bluuebunny/crossref_metadata_2025 huggingface dataset:
Multilayer Perceptron Predicting Cervical Lymph Node Metastasis for Papillary Thyroid Carcinoma
Authors: Shi Jing-wen , Zhang Qi , Zhu Tian-tong , Huang Ying
Published: February 2022

Background: Lymph node metastasis is related to thyroid cancer recurrence; hence, early identification and prediction of cervical lymph node metastasis (CLNM) in thyroid cancer are essential.

Materials and methods: Ultrasound characteristics and patients’ clinical information for 478 thyroid nodules from 383 patients were collected, and a multilayer perceptron (MLP) was used to train and test the veracity to predict CLNM and form a network model. Sixty new patients with papillary thyroid carcinoma (PTC) were evaluated with the MLP neural network model. The metastasis status of these patients was then compared with the pathological results. The prediction of metastasis by the MLP and by multiple regression was compared.

Results: Calcification, age, sex, and maximum diameter were important predictive factors of CLNM by the MLP, and the area under the receiver operating characteristic curve was 0.715. No significant differences were found between the MLP and multiple regression in predicting CLNM. The average confidence of the model used in these new patients in predicting metastasis with PTC was 68.9%.

Conclusion: Ultrasound images from thyroid nodule characteristics and patients’ clinical information can be used as predictive factors of CLNM by the MLP method to a certain extent.
S-Nitrosylation of p62 Inhibits Autophagic Flux to Promote α-Synuclein Secretion and Spread in Parkinson's Disease and Lewy Body Dementia
Authors: Oh Chang-ki , Dolatabadi Nima , Cieplak Piotr , Diaz-Meco Maria T. , Moscat Jorge , Nolan John P. , Nakamura Tomohiro , Lipton Stuart A.
Published: February 2022

Dysregulation of autophagic pathways leads to accumulation of abnormal proteins and damaged organelles in many neurodegenerative disorders, including Parkinson's disease (PD) and Lewy body dementia (LBD). Autophagy-related dysfunction may also trigger secretion and spread of misfolded proteins, such as α-synuclein (α-syn), the major misfolded protein found in PD/LBD. However, the mechanism underlying these phenomena remains largely unknown. Here, we used cell-based models, including human induced pluripotent stem cell-derived neurons, CRISPR/Cas9 technology, and male transgenic PD/LBD mice, plus vetting in human postmortem brains (both male and female). We provide mechanistic insight into this pathologic pathway. We find that aberrant S-nitrosylation of the autophagic adaptor protein p62 causes inhibition of autophagic flux and intracellular buildup of misfolded proteins, with consequent secretion resulting in cell-to-cell spread. Thus, our data show that pathologic protein S-nitrosylation of p62 represents a critical factor not only for autophagic inhibition and demise of individual neurons, but also for α-syn release and spread of disease throughout the nervous system.

SIGNIFICANCE STATEMENTIn Parkinson's disease and Lewy body dementia, dysfunctional autophagy contributes to accumulation and spread of aggregated α-synuclein. Here, we provide evidence that protein S-nitrosylation of p62 inhibits autophagic flux, contributing to α-synuclein aggregation and spread.
Development of Computer Based Diagnostic Assessment Completed with Simple Harmonic Movement Material Remedial Program
Authors: Kurniawan B R , Kusairi S. , Puspita D. A. , Kusumaningrum R. W.
Published: February 2022

Research and development of computer-based assessment is carried out to overcome the shortcomings of conventional paper-based assessment. Development is carried out by focusing on the use of isomorphic questions and improvement programs. This computer-based assessment was developed with two levels of questions. At each level there are isomorphic questions that are used as a reference in providing feedback to students about their concepts understanding. At each level there is also video material that can be used as a source of student learning before students utilize the remedial program. This computer-based assessment has been tested on 31 third-year undergraduate students in Physics Education, Universitas Negeri Malang. The results of media and material validation and the results of limited trials indicate that the computer-based assessment produced is feasible to be applied in learning.
Analysis of Creativity and Attitudes Caring The Environment of Junior High School Students: Study of Environmental Physics Learning Using Learning Modules
Authors: Amelia T. , Jumini S. , Khoiri A.
Published: February 2022

The natural and socio-cultural environment of the Wonosobo community has various potentials that can be explored and developed to support the science learning process. Pranotomongso is a form of culture used by farmers to cultivate nature. This study aims to determine the application of ethnoscience-based integrated science learning to foster environmental awareness and student creativity. This research is a quantitative study using the True Experimental method, with a Posttest Only Control Design, the sampling technique is random sampling. The instruments used for data collection were tests and questionnaires to measure creativity and environmental awareness. The data analysis technique used one-party t-test. The results showed that ethnoscience-based integrated science learning can foster environmental awareness and student creativity and can improve environmental care and student creativity in ethnoscience-based integrated science learning, in the medium category. This research is very useful in showing how science works in society, and it is more applicable.Â Â Â Â Â
Increasing Student's Hots Using Mobile Technology and Scaffolding Approach on Sound Wave Material
Authors: Tuada R N , Suparno S
Published: February 2022

The higher order thinking skills (HOTS) of students in Indonesia is still low. This study aims to determine the effectiveness of using Android-based interactive physics learning media with a scaffolding approach on Sound Wave material to increasing higher order thinking skills. This study used a Pre-Experimental with one Group Pretest-Posttest Design. The evaluation instrument developed was a higher order thinking skills test instrument in the form of reasoned multiple choice. Data were analyzed with descriptive statistics and used the Anava test. The result showed that the use of Android-based Mobile Interactive Physics Learning Media with the Scaffolding approach on Sound Waves material proved to be effective in increasing students' HOTS abilities. This can be seen from the results of the effectiveness test, size-effect, and the size of the effective contribution that has been made showing that learning with the scaffolding approach assisted by the IPMLM application has increased higher than the control class.
Articular spacers in two-stage revision arthroplasty for prosthetic joint infection of the hip and the knee
Authors: Craig Andy , King S W , van Duren B H , Veysi V T , Jain S , Palan J
Published: February 2022

Use of articular antibiotic-eluting cement spacers during two-stage revision arthroplasty for prosthetic joint infection (PJI) is a long-established and proven adjunctive technique during first-stage surgery. Articular spacers come in many forms, either static or dynamic. The authors present an instructional review of current evidence regarding their use.

A total of 45 studies (for spacer use in PJI involving either hip or knee) were analysed for data regarding eradication rate, functional outcomes, mechanical complications and the impact on second-stage surgery. A large number of case series and retrospective cohort studies were retrieved, with only a small number of prospective studies (2).

High levels of infection eradication were commonly reported (>80%). Outcome scores were commonly reported as indicating good-to-excellent function and pain levels. Second-stage procedures were often not required when dynamic spacers were used. Static spacers were associated with more mechanical complications in both the hip and the knee. In the hip, dynamic spacers were more commonly associated with instability compared to static spacers. Consideration should be given to the use of dual-mobility or constrained definitive acetabular components in these cases at second-stage surgery.

The use of antibiotic-eluting polymethylmethacrylate articular spacers in two-stage revision for PJI of hip and knee arthroplasty achieves a high rate of infection eradication. Dynamic spacers may confer a variety of benefits compared to static spacers, with a similar rate of infection eradication.
Endothelin 2: a key player in ovulation and fertility
Authors: Ko CheMyong J , Cho Yoon Min , Ham Eugene , Cacioppo Joseph A , Park Chan Jin
Published: February 2022

Ovulation is the fundamental biological process during which an oocyte is expelled from the ovary, and it is an essential step toward establishing a pregnancy. Understanding regulatory mechanisms governing the ovulation process is essential for diagnosing and treating causes of infertility, identifying contraceptive targets, and developing novel contraception methods. Endothelin-2 (EDN2) is a 21 amino acid-long peptide that is transiently synthesized by granulosa cells of the ovulatory follicle prior to ovulation and plays an essential role in ovulation via promoting contraction in the myofibroblast cells of the theca layer of the follicle. This review describes the organization of the endothelin system, summarizes recent findings on the expression and synthesis of the endothelin system in the ovary, illustrates the roles that EDN2 plays in regulating ovulation, and discusses EDN2 as a potential target of contraception.
Magnetite nanoparticles synthesized using grape fruit extract: synthesis, morphology, hyperthermia application and catalytic activity in hydrogen peroxide decomposition
Authors: Danyliuk Nazarii , Lischynska Sofia , Tatarchuk Tetiana , Kotsyubynsky Volodymyr , Mandzyuk Volodymyr
Published: February 2022

The paper presents a simple one-step "green" approach to the synthesis of magnetite nanoparticles. The magnetite nanoparticles were synthesized using fruit extract obtained from grape peels and grape pulp. The formation of magnetite nanoparticles was confirmed by X-ray diffraction analysis (XRD), infrared spectroscopy (IR), Mössbauer spectroscopy, scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS). The crystallites sizes of magnetite nanoparticles are 7 and 14 nm for Fe3O4-peel and Fe3O4-pulp samples, respectively. Scanning electron microscopy images show that the samples consist of agglomerated nanoparticles. The synthesized magnetite nanoparticles showed good prospects for their use in magnetic hyperthermia. SAR values ​​of 0.488 W/g and 1.330 W/g for Fe3O4-peel and Fe3O4-pulp samples, respectively. The synthesized magnetic nanoparticles show excellent colloidal stability in the aqueous solutions. The maximum hyperthermia temperatures are 42.28 °C and 42.48 °C for Fe3O4-peel and Fe3O4-pulp samples, respectively. Studies of the catalytic activity of magnetite were performed in decomposition of hydrogen peroxide in a batch mode. The degrees of H2O2 decomposition are 67.5% and 65.25% for the Fe3O4-peel and Fe3O4-pulp samples respectively. The high catalytic activity of the synthesized samples makes them promising candidates for the decomposition of hydrogen peroxide in wastewater disinfection.
La desaparición del pueblo coxoh de Escuintenango, Chiapas. Siglos XVI-XIX
Authors: Martínez González Alma Rosa
Published: February 2022

Este artículo pretende exponer el porqué de la desaparición de Escuintenango, en Chiapas, México, un pueblo maya de habla coxoh. Dicha población, cuya importancia residía principalmente en ser parte del Camino Real de Guatemala –imprescindible para la comunicación de la época–, desapareció dejando solo ruinas entre campos de ganado vacuno. Este trabajo es el resultado del estudio de documentos de los siglos XVI al XIX hallados en el Archivo Histórico Diocesano de San Cristóbal de Las Casas. La documentación reveló los problemas demográficos de Escuintenango y la continua disposición de las autoridades por evitar su desaparición. A partir de esta investigación se pudo concluir que su desaparición fue un proceso de larga duración que respondió a varios factores, entre los cuales están: lo inhóspito de la zona del asentamiento por las constantes inundaciones, la migración de sus habitantes a lugares más prósperos, como el Soconusco, el creciente auge de las estancias ganaderas, las epidemias y la explotación laboral.
San Gerónimo Zacualpa: Pueblo de indios, trapiche de caña y obra pía (Chiapas, 1660-1725)
Authors: Barrera Aguilera Óscar Javier
Published: February 2022

Acá se presentan algunos aspectos relativos al cambio en el uso, posesión y renta de las tierras que alguna vez pertenecieron al común de indios del pueblo de Zacualpa, a lo largo del siglo XVII. El punto de partida son unas generalidades con respecto al universo legal y administrativo que compartieron los reinos de las Indias occidentales cobijados por el imperio español. A continuación, nos sumergimos en la provincia de Los Llanos para mostrar sus particularidades geográficas, económicas, sociales y culturales. El grueso de este trabajo es el análisis de una docena de expedientes que dan cuenta de los vaivenes en la posesión y administración de los terrenos ubicados en Zacualpa: un pueblo desaparecido de la Depresión Central de Chiapas. El hilo conductor son los mecanismos legales que permitieron dichas transacciones agrarias. La apuesta metodológica es ilustrar la combinación de diferentes órdenes legales en medio de relaciones sociales cambiantes.
La aventura es descubrirnos: Reflexiones teóricas y metodológicas para una educación e historia feminista “desde la otra esquina”
Authors: Abarca Salinas María Elena
Published: February 2022

From the recognition of some historical experiences from feminist activists and experiences of personal political activism, notes, reflections, and proposals are proposed —as clues— about a feminist education, from educational spaces and formal classrooms and non-school training spaces, maybe not academic, but activist politics. What are the implications of a feminist education? In what way can we think and propose a history about women in the classroom? What civilizing project do we need to know and involve, from the everyday, the intimate, the private and the public? These are some questions, by way of invitation, that guide this article.
Biochemical markers of hepatobiliary system functional state in rats under the action of laser irradiation and ω-3 polyunsaturated fatty acids
Authors:   Yuriy Fedkovych Chernivtsi National University, 2 Kotsyubynskoho str., Chernivtsi, 58012, Ukraine, Ketsa O. V. , Kapitanchuk I. Y. ,   Yuriy Fedkovych Chernivtsi National University, 2 Kotsyubynskoho str., Chernivtsi, 58012, Ukraine
Published: February 2022

Markers of the functional state of the hepatobiliary system — enzymatic activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyltransferase (GGT), levels of total and direct bilirubin, the value of thymol probe in the plasma of the diaphragm waves and the introduction of ω-3 PUFA were investigated. It has been found that the action of laser irradiation in blood plasma increases the enzymatic activities of aminotransferases and GGT, along with an increase in the level of total and direct bilirubin and thymol index. The corrective effect on the liver functional state is shown by ω-3 polyunsaturated fatty acids (PUFA). It has been established that the protective properties of ω-3 PUFAs depend on the scheme of their introduction. The highest hepatoprotective effect of ω-3 PUFAs is manifested under the conditions of their previous introduction to the action of laser irradiation, as evidenced by a decrease in hyperenzymemia ALT, AST, GGT, a decrease in total and direct bilirubin and thymol in plasma. The introduction of ω-3 PUFA after the end of the laser diode does not change the markers of the functional state of the liver in blood plasma compared with irradiated animals that were not injected with the studied lipophilic nutrients.
The influence of biologically active preparations on the reproductive qualities of sows
Authors:   State Agrarian University of Moldova, 42 Mirceşti str., Chişinău, MD-2049, Republic of Moldova, Pîrlog A. , Carapirea A. ,   State Agrarian University of Moldova, 42 Mirceşti str., Chişinău, MD-2049, Republic of Moldova, Darie G. ,   State Agrarian University of Moldova, 42 Mirceşti str., Chişinău, MD-2049, Republic of Moldova, Cibotaru E. ,   State Agrarian University of Moldova, 42 Mirceşti str., Chişinău, MD-2049, Republic of Moldova, Chiselița O. ,   State Agrarian University of Moldova, 42 Mirceşti str., Chişinău, MD-2049, Republic of Moldova
Published: February 2022

The work concerns the study of the reproductive qualities of sows that received, in addition to the main diet, a biologically active preparation (LB-AAP) synthesized from brewer’s yeast waste. For this purpose, two groups of sows were formed, experimental and control ones containing 5 sows in each group. The preparation was administered in addition to the main diet 30 days before farrowing and 10 days after farrowing at 10 ml for each sow. It has been found out that the enrichment of rations for pregnant sows with a biologically active preparation (LB-AAP) allows an increase in the number of born piglets by 0.4 more than in the control group. There were 0.8–0.31 stillborn piglets in the experimental group or 1.0 less compared to the control group. Enrichment of the diets of sows 30 days before farrowing with a biologically active agent had a positive effect on the live weight of the litter at birth and on the 21st day. The average live weight of piglets in the litter of the experimental group was 0.85 kg higher than the average live weight of piglets in the litter of the control group. The average live weight of one piglet at birth in the experimental group was 1.7 kg, and in the control group was 1.4 kg, which is 0.3 kg less. Hematological and biochemical blood tests were studied at the beginning and at the end of the experiment, as well as the amino acid, macro and microelement composition of the preparation.
Efficiency of “Biolide” disinfectant working solutions for action on gram-negative and gram-positive bacteria
Authors:   State Research Institute of Laboratory Diagnostics and Veterinary and Sanitary Examination, 30 Donetska str., Kyiv, 03151, Ukraine, Chechet O. N. , Kovalenko V. L. ,   State Scientific Control Institute of Biotechnology and Strains of Microorganisms, Garkavenko T. O. ,   State Research Institute of Laboratory Diagnostics and Veterinary and Sanitary Examination, 30 Donetska str., Kyiv, 03151, Ukraine, Gorbatyuk O. I. ,   State Research Institute of Laboratory Diagnostics and Veterinary and Sanitary Examination, 30 Donetska str., Kyiv, 03151, Ukraine, Kozytska T. H. ,   State Research Institute of Laboratory Diagnostics and Veterinary and Sanitary Examination, 30 Donetska str., Kyiv, 03151, Ukraine
Published: February 2022

The article presents the results of the new developed disinfectant “Biolide” research for use in poultry and other sectors of agriculture, because today the problem of developing cheap and effective disinfectants remains relevant. In recent years, the poultry industry has a tendency to rapid development, since the population’s demands for poultry products have increased markedly. With an integrated approach to the production of chicken meat, it is possible to increase the productivity of poultry enterprises, energy efficiency and reduce the cost of production. When applying such an integrated approach, one of the important roles is played by the provision of high-quality disinfection with effective and inexpensive means. In connection with the relevance of the development of new effective disinfectants, the main purpose of the research was to determine the effectiveness of working solutions in concentrations of 0.1; 0.2; 0.25 and 0.5% for gram-negative E. coli ATCC 25922 and gram-positive S. aureus ATCC 25923 for different periods of time — 20, 30, 60 and 120 min. after the simulation of protein contamination. Test cultures E. coli ATCC 25922 and S. aureus ATCC 25923 in lyophilized form were stored in a refrigerator at a temperature –70±5°C. By replacing them on nutrient media, metabolic processes were restored and their correspondence to the main typical properties for this type of pathogens was checked. Simulation of protein contamination was carried out using sterile inactivated blood serum of cattle in the amount of 40.0% to the volume of the used bacterial suspension. In laboratory tests, smooth surfaces of tiles with an area 100 cm2 were used as test objects. The analysis of the obtained research results showed the high efficiency of 0.5% working solutions of the new disinfectant “Biolide” when exposed to test cultures E. coli ATCC 25922 and S. aureus ATCC 25923 for 60 min., since this concentration of the working disinfectant solution and the exposure time ensured the destruction by 99.99–100.0% of gram-negative and gram-positive microorganisms when imitating protein contamination of test objects.
Феноменологічна теорія переривчастого режиму межового тертя
Authors: Ляшенко Я.О. , Хоменко О.В. , Метлов Л.С.
Published: February 2022

Побудовано детерміністичну теорію плавлення ультратонкої плівки мастила, яку затиснуто між двома атомарно-гладкими твердими поверхнями. Для опису стану мастила введено параметр надлишкового об'єму, що виникає за рахунок хаотизації структури твердого тіла у процесі плавлення. Узгоджено описано термодинамічне і зсувне плавлення. Проаналізовано залежності стаціонарної сили тертя від температури мастила і швидкості зсуву поверхонь, що труться, при їх рівномірному зсуві зі сталою швидкістю. У межах простої трибологічної моделі описано переривчастий режим тертя, при якому мастило періодично плавиться і твердне. Проаналізовано вплив швидкості, температури і навантаження на переривчасте тертя.Проведено якісне порівняння отриманих результатів із експериментальними даними.
Uso de aloinjerto estructural e infecciones posquirúrgicas
Authors: Jorge Fernando Daniel , Varaona José María , Basso Mariela
Published: February 2022

Introducción: El uso de aloinjertos conlleva el riesgo de complicaciones. Una de las más frecuentes es la infección. Un importante factor de riesgo de infección con el uso de injertos óseos es la transmisión de gérmenes a través del injerto. Nuestros objetivos fueron determinar si existe una relación entre la posible contaminación de los injertos de este Banco y las infecciones posquirúrgicas; demostrar cómo la selección del donante, la procuración y el procesado del injerto adecuados disminuyen la tasa de contaminación e informar otras complicaciones relacionadas con la calidad del injerto.

Materiales y Métodos: Se seleccionaron pacientes que recibieron injerto óseo estructural de nuestro Banco. Todos los injertos fueron estudiados microbiológicamente. Se revisaron las historias clínicas, y los pacientes fueron sometidos a una anamnesis y un examen físico, y se les tomaron radiografías para detectar infección y otras complicaciones. Se utilizó la Escala de Osteointegración ISOLS.

Resultados: En ninguno de los injertos, se detectó contaminación. Se identificó un caso (7,7%) de infección por Klebsiella pneumoniae productora de carbapenemasas y 3 casos (23%) de falta de integración. La integración fue entre buena y excelente en el 77% de los casos, satisfactoria en el 8% y pobre en el 15%. No hubo otras complicaciones.

Conclusiones: Existe riesgo de transmisión de infecciones con el aloinjerto estructural. Los criterios reglados de selección de donantes y el control de los procedimientos dentro del banco de huesos disminuyen el riesgo de infección por contaminación del injerto y de otras complicaciones relacionadas con la calidad del injerto.
Variantes anatómicas del tubérculo de Lister. Presentación de una clasificación imagenológica y su utilidad clínica
Authors: Sala Matías , González Juan Francisco
Published: February 2022

Objetivo: Evaluar, en forma retrospectiva, las diferentes variantes de los tubérculos de Lister y el extensor largo del pulgar en imágenes de resonancia magnética de muñecas y, sobre la base de dichos hallazgos, proponer variables a la clasificación.

Materiales y Métodos: Estudio retrospectivo utilizando imágenes de resonancia magnética entre el 1 de marzo y el 10 de noviembre de 2019. Se incluyeron imágenes de muñeca de pacientes sanos (cortes axiales, sagitales y coronales de 1 mm de espesor), >18 años, sin fractura de muñeca o del carpo, previa o actual, y se excluyó a quienes no cumplían estos criterios. Se analizaron el tubérculo de Lister, la altura de los picos radial y cubital, el ángulo, la longitud del tubérculo, la profundidad de los valles y la altura del tabique. Se evaluó el extensor largo del pulgar analizando la altura, el espesor, la superficie y la presencia o no inflamaciónasociada.

Resultados: Se analizaron 500 imágenes de muñeca, y se obtuvieron 11 subtipos de tubérculo de Lister: 411 tipo 1, 58 tipo 2 y 26 tipo 3. Dentro de estos, el más frecuente fue el tipo 1B. El 26,6% tenía inflamación asintomática en el tercero y cuarto compartimento.

Conclusiones: El tubérculo de Lister es importante en muchos procedimientos y sirve como punto de referencia anatómico; por lo tanto, es preciso conocer su patrón más frecuente y sus variantes anatómicas. Proponemos una ampliación de la clasificación, adicionando nuevos tipos de tubérculo por conocer y su relación con el extensor largo del pulgar.
Prevención, manejo y seguimiento de las lesiones de la arteria vertebral. Conocimiento actual de los cirujanos de columna de la Argentina
Authors: Illanes Cristian , Cubile Mariano , Solsona Sebastián , Herrero Verónica , Medina Daniela , Estay Ayelén
Published: February 2022

Introducción: La lesión de la arteria vertebral es un evento grave. El objetivo del estudio fue evaluar el grado de conocimiento de los cirujanos de columna en la Argentina sobre las medidas diagnósticas y terapéuticas de la lesión de la arteria vertebral.

Materiales y Métodos: Se realizó un estudio descriptivo observacional mediante una encuesta difundida a través de la AANC y la SAPCV.

Resultados: Se recibieron157 respuestas. El 47,4% considera relevante evaluar la anatomía de la arteria vertebral en todo tipo de patología mediante métodos angiográficos. La mitad de los encuestados diagnosticó una variante anatómica de la arteria. El 29,2% manifestó haber tenido en su práctica una lesión de la arteria. Solo el 35% tiene un protocolo de acción para el manejo de este evento adverso. El 77% adopta como primera medida el taponamiento. En el seguimiento posquirúrgico, la mayoría estudia el estado final mediante métodos angiográficos. Alrededor del 10% procuraría instaurar alguna medida de profilaxis antitrombótica. El 76,6% dispone de Servicio de Hemodinamia con cirujano endovascular.

Conclusión: Esta complicación está subestimada. Menos de la mitad de los cirujanos utiliza, como rutina, herramientas de diagnóstico de posibles alteraciones anatómicas. No se han observado protocolos de manejo ni seguimiento de estas lesiones.
Artritis séptica acromioclavicular por Staphylococcus argenteus. Reporte de un caso
Authors: Cullari Leonardo Matías , Quiroga Gonzalo , Viollaz Gonzalo Martín
Published: February 2022

La artritis séptica acromioclavicular es un cuadro sumamente infrecuente que, por lo general, se presenta en articulaciones con alta vascularización, como cadera, rodilla y hombro. El microorganismo aislado con más frecuencia es Staphylococcus aureus. Describimos a una paciente de 56 años con artritis séptica acromioclavicular, que requirió una intervención quirúrgica de urgencia. Otra particularidad del caso es el germen aislado, Staphylococcus argenteus, una bacteria muy infrecuente en este tipo de enfermedad.
Fracturas vertebrales múltiples
Authors: Bazán Pedro Luis , Avero González Richard Alejandro , Patalano Luis , Borri Álvaro Enrique , Medina Martín , Cortés Luengo Carlos , Gutiérrez Edgar Enrique , Soria Adaro José Carlos , Ciccioli Nicolás Maximiliano , Acevedo Yoga Joel
Published: February 2022

Introducción: Las fracturas vertebrales múltiples son el resultado de traumatismos de alta energía. Se clasifican en contiguas cuando hay fractura de dos o más cuerpos vertebrales en forma adyacente y no contiguas cuando hay lesiones de varios niveles separadas por, al menos, una vértebra sin lesión.
Objetivos: Evaluar la clínica y la cinemática de las fracturas vertebrales múltiples, establecer su distribución, evaluar la asociación con lesiones extravertebrales y detallar las complicaciones.
Materiales y Métodos: Estudio multicéntrico, prospectivo y observacional de pacientes con fracturas vertebrales múltiples.
Resultados: 66 pacientes (26 mujeres y 40 hombres; promedio de edad 39 años) con 196 lesiones vertebrales, 55 no tenían déficit neurológico. Cinemática: 32 accidentes automovilísticos, 27 caídas de altura, 5 traumas directos y 2 traumas deportivos. Topografía: dos C0-C3, cuatro C3-C7, ocho C7-T1, 61 T1-T10, 91 T10-L2, 28 L2-L5 y una sacro. Combinación: 21 toracolumbar-toracolumbar y 8 torácica-torácica. Treinta y dos fracturas eran contiguas; 19, no contiguas y 15 tenían un patrón mixto. Veintiséis pacientes presentaron47 lesiones extravertebrales (20 politraumatismos), 12 traumas torácicos. Treinta y seis pacientes recibieron tratamiento conservador y 30 fueron operados.
Conclusiones: La presencia de fracturas vertebrales múltiples es frecuente y son consecuencia de accidentes automovilísticos, la mayoría de los pacientes no tiene compromiso neurológico. El sector más afectado fue entre T2 y L5, la combinación más frecuente fue toracolumbar-toracolumbar, seguida de torácica-torácica. Las lesiones extravertebrales más frecuentes fueron traumatismos de cráneo y de tórax.
Resolución del caso
Authors: Re Rodrigo , Negri Maximiliano
Published: February 2022

Se describe la patología presentada como tumor de partes blandas, Rabdomiosarcoma alveolar y se señala diagnosticos diferenciales por imágenes.
Hemiparesis With Hypoglycemia in a Child With Hypopituitarism Involving LHX4 Gene Deletion
Authors: Akinseye Leah , Ward Jewel , Lahoti Amit
Published: February 2022

We report a case of a 17-month-old boy with developmental delay who presented with acute-onset right-sided hemiparesis and hypoglycemia. Severe hypotension developed during his sedation for MRI and magnetic resonance angiography. Imaging revealed a hypoplastic pituitary gland within a shallow sella turcica and findings suggestive of moyamoya syndrome. Hemiparesis resolved 5 hours after correction of hypoglycemia with dextrose infusion, and severe hypotension improved with crystalloid fluids and vasopressors. Magnetic resonance angiography repeated 24 hours later revealed resolution of the vascular finding. Additional biochemical testing was consistent with hypopituitarism, and genetic evaluation revealed that the patient had a microdeletion including the LHX4 gene, which has been implicated in combined pituitary hormone deficiency type IV. Hypoglycemia frequently presents with autonomic or neuroglycopenic symptoms. However, when hypoglycemia presents with an isolated neurologic deficit like hemiparesis with preservation of alertness, it can be challenging to differentiate a cerebrovascular event from hypoglycemia-induced symptoms, leading to a delay in endocrine evaluation. Hypoglycemic hemiparesis is rare in childhood and is reported in children with diabetes mellitus or hyperinsulinism. This case expands the clinical spectrum of hemiparesis as a presenting sign of hypoglycemia in growth hormone and adrenocorticotropic hormone/cortisol deficiencies.
Sound in documentaries as a tool of expression instead of representation
Authors: Martinez Muñoz Diana Carolina
Published: February 2022

The concept of reality in the context of documentaries has always been a focus of controversy, with manipulation of captured material during the filmmaking process being disallowed or labelled inauthentic. Nonetheless, some documentaries have approached the filmmaking process in an experimental way and are using a different approach to represent reality. At the same time, sound in documentaries is still usually misunderstood as a medium in which manipulation, processing – or even more radically – the creation from scratch, is not encouraged or not properly understood. This article proposes to portray the production of sound in films as a collaborative process that enables the director to think of sound as an element of expression – a tool with which to describe reality from another perspective, capable of creating possibilities for the sound director to translate emotions and feelings into sonorities due to the versatility of human sound perception. The usage of sound should take risks; experimentation with it empowers sound to become more creative and more radical.
Physical-Mechanical properties of H-10 blocks manufactured in Norte of Santander, Colombia: a case study
Authors: García-León Ricardo Andrés , Afanador-García Nelson , Guerrero-Gómez Gustavo
Published: February 2022

This work presents the physical-mechanical properties of two types of H-10 blocks of six holes fabricated in two different companies in Norte de Santander, Colombia to provide a general visualization of the ceramic properties of masonry products base clay. Random samples of H-10 blocks were collected from the selected companies directly from the furnace as part of the experimental procedure, which was used to perform the physical-mechanical tests such as initial and final water absorption, morphology, resistance to compression, and flexion according to the NTC 4017 standard procedure, the results obtained were compared with the values established in the NTC 4205 standard procedure, used as non-structural masonry products for indoor or outdoor use. Finally, the SEM-EDS micrographs exposed the maincharacteristic chemical elements (Al, Si, O), defects on the surface of an H-10 block and the presence of typical phases (Quartz, Kaolinite, Illite, and Hematite) obtained by the XRD technique.
Optimization tools applied to physical asset maintenance management: state of the art
Authors: Borroto Pentón Yodaira , Caraza Morales Manuel Alejandro , Alfonso Llanes Aramis , Marrero Delgado Fernando
Published: February 2022

This article presents the state of the art of the application of optimization tools such as Genetic Algorithms, Simulation, Neural Networks, Markov Chains and Bayesian Networks in the physical asset maintenance management. The bibliographic references used were extracted from a detailed search that allowed the selection of the empirical studies presented, in the time horizon from 2010 to 2021, through databases, research platforms and online libraries. The analysis of the identified case studies is carried out, taking into account the variables involved in the study, the optimization tool used, and the result obtained in the analysis of the physical asset maintenance management. The benefits of the application of optimization tools are identified and it is confirmed that maintenance costs and intervention times are present variables, which contribute to the improvement of reliability and maintenance management.
Structural behavior of construction typologies of the Great Soviet Panel in an area of high seismic danger
Authors: Socarrás Cordoví Yamila concepción , Alvarez-Deulofeu Eduardo , Pupo-Sintras Nereyda
Published: February 2022

In a sample of 200 buildings built with the Great Soviet Panel prefabricated system in Santiago the Cuba, pathological damage and structural transformations carried out by the inhabitants are evidenced. Being necessary to evaluate a priori, the incidence of the aspects leading to potential seismic damages in the structural behavior of these buildings. To meet this objective, 16 hypothetical variants were elaborated, taking into account the statistical analysis of the diagnosis made, which are compared with the 4 variants of the original typologies. It is concluded that the aspects conducive to potential seismic damages have more repercussion in the change of the oscillation periods than in the seismic demand. Pathological damage is the one with the highest incidence in the increase in the fundamental periods of vibration, followed by the increase in weight and the openings of panels or slabs.
Adrián Celentano, dir. 1938: reforma universitaria, higiene social y antifascismo en la UNLP. Itinerarios, militancias y publicidades en torno a las conmemoraciones del ‘18
Authors: Gutiérrez-Rodríguez Carlos-Arturo
Published: February 2022

Reseña del número 42 Adrián Celentano, dir. 1938: reforma universitaria, higiene social y antifascismo en la UNLP. Itinerarios, militancias y publicidades en torno a las conmemoraciones del ‘18. La Plata: Centro de Documentación e Investigación de la Cultura de Izquierdas, 2019. 146 pp.
Arqueología y prácticas científicas vocacionales: el caso de Amelia Larguía de Crouzeilles (1875-1952)
Authors: Arias Ana-Carolina
Published: February 2022

el objetivo de este artículo es analizar el papel de las prácticas vocacionales en la ciencia. En particular, se analiza el caso de Amelia Larguía, quien intervino en los debates y discusiones en torno a un conjunto de piezas arqueológicas halladas en la década de 1930 en la región del Arroyo Leyes (provincia de Santa Fe, Argentina). Para ello, se recurre a diferentes fuentes documentales conservadas en acervos de distintas ciudades del país, incluidos el inventario y las piezas de la colección arqueológica de Larguía. Como resultado en este artículo se muestra la manera en que los aficionados se insertaron en las redes de circulación de materiales y datos y cómo ciertas prácticas científicas vocacionales contribuyeron a modelar las discusiones y debates centrales de la arqueología en la Argentina entre las décadas de 1930 y 1940.
Colombia en las redes epistémicas transnacionales de eugenesia (1920-1940)
Authors: Olaya-Peláez Iván-Darío
Published: February 2022

el “clima de ideas” que surgió en el mundo occidental en torno a la degeneración racial y la eugenesia como su solución condujo a la constitución de una red epistémica transnacional. Los jóvenes países latinoamericanos en la búsqueda de construir Estadosnaciones basados  en la idea de “progreso” y “civilización” adhirieron este movimiento pues el futuro de la nación dependía de la buena constitución genética del pueblo. Por eso, entre 1920 y 1940 comenzó a constituirse un proyecto eugenésico panamericano el cual adoptaría políticas de control de la población para así producir el hombre americano “apto”. Aunque la eugenesia no se institucionalizó en Colombia, el país no estuvo ajeno al movimiento. Sus principios, recomendados por algunos expertos colombianos, impregnaron proyectos sociales y leyes públicas nacionales de inmigración y protección infantil. A través de la revisión de las actas de congresos especializados panamericanos, este artículo muestra la integración de los expertos colombianos a las redes epistémicas eugenésicas latinoamericanas y su participación en la puesta en marcha del proyecto eugenésico panamericano entre 1920 y 1940.
La participación de la élite indígena de la provincia de Guane en la cofradía de Nuestra Señora del Rosario (1638-1752)
Authors: Monroy-Merchán María del Pilar
Published: February 2022

después del proceso de conquista la nobleza indígena tuvo que adaptarse a la nueva estructura de dominio hispánico y convertirse en mediadora entre las autoridades colonialesy la comunidad de origen. Este artículo reconstruye la incorporación de la élite indígena de laprovincia de Guane en las cofradías católicas. ¿Qué papel jugaron las autoridades indígenas en el proceso de consolidación de una corporación religiosa durante los siglos XVII y parte del siglo XVIII en el pueblo de indios de Moncorá? Para dar cuenta de este proceso se analiza de manera inductiva el Libro de la Cofradía y Hermandad de Nuestra Señora del Rosario y se extraen algunos datos estadísticos con el fin de identificar la participación de caciques y cacicas en el sistema de cargos de la corporación religiosa. La información suministrada revela que la nobleza indígena se integró de manera colectiva en la cofradía durante el siglo XVII. No obstante, al finalizar dicha centuria cedió su participación a indígenas del común, retrayéndose las autoridades indígenas a la periferia donde llevaron consigo las prácticas devocionales como el rezo del rosario.
Informe sobre exploración del alto de Santa Elena (Medellín, Colombia, 1871)
Authors: Zapata-Hincapié Oscar-Javier
Published: February 2022

durante el siglo XIX la población de Medellín (Colombia) empezó a crecer y habitar a ambos lados de la quebrada Santa Elena. Controlar la furia de este afluente en épocas invernales se había vuelto un tema preocupante para la administración municipal. Por tal razón, se buscó el apoyo del ingeniero francés Eugenio Lutz quien en 1871 presentó al Gobierno local un proyecto para intervenir la alta montaña con el propósito de desviar la quebrada y así poder controlar las avalanchas o también llamadas “avenidas” que afectaban a los habitantes del valle. A continuación se presenta la transcripción del informe entregado por Lutz al Cabildo, en el cual el francés informa sobre la exploración realizada en la cuenca alta de la quebrada y la propuesta técnica y económica para ejecutar la obra correctiva. El documento resulta revelador sobre la historia urbana reciente de Colombia y constituye un aporte a la historia ambiental de una ciudad que ad portas del siglo XX sufría graves estragoscausados por la naturaleza circundante.
Case report of Laryngeal Amyloidosis: Unusual cause of hoarseness
Authors: Khamalrudin Noraimi , Mohamad Yunus Mohd Razif , Mat Baki Marina , Kin Foong Seong
Published: February 2022

Background: Laryngeal amyloidosis is a rare pathology of the airway in which the diagnosis can only be made via tissue biopsy.Â We reported a case of laryngeal amyloidosis presenting with symptoms of hoarseness and voice fatigue.Case report: This is a case report of laryngeal amyloidosis in a middle-aged female patient who presented with hoarseness of voice. Upon obtaining a further history and performing a clinical examination, it was noted that the patient had a laryngeal mass. She underwent surgery, and the mass was histopathologically confirmed as laryngeal amyloidosis. She was successfully treated with a combination of surgical and medical treatment. This case presentation describes these rare pathological findings, their clinical manifestations, the histopathological and surgical diagnostic problems, treatment and patientâ€™s progress that we followed up till presence.Conclusion: Isolated laryngeal amyloidosis is a rare benign laryngeal tumor that is often presented with various symptoms depending on the tumor location and can even cause upper airway obstruction. It is a histological diagnosis confirmed by histopathological specimens that are stained with Congo red. Treatment of laryngeal amyloidosis includes symptomatic relief, surgical or even conservative treatment.Â
Evaluation of chronic disease management programs in developed and underdeveloped regions in Indonesia
Authors: Kasim Ahmad Muhammad , Mahendradhata Yodi , Trisnantoro Laksono
Published: February 2022

Introduction: Chronic diseases have become a major cause of death in the world, and a major source of morbidity and misery. Approximately 80% of related deaths occur in developing countries. Chronic Disease Management Program (CDMP) is an integrative program aimed to control the prevalence of chronic diseases. Therefore, this study aimed to evaluate the interaction between context and process in CDMP services, and to determine how CDMP was implemented in developed and underdeveloped regions.Methods: This qualitative study used the Consolidated Framework for Implementation Research (CFIR). Subjects were selected by purposive sampling from CDMP organizers in Primary Health Centers for a commitment-based capitation assessment. Transcript data were analyzed thematically by summarizing and identifying major themes based on the CFIR domains.Results: The main activities of the CDMP (medical consultations, monitoring of health status, health educational, reminders, home visit and group activities/gymnastics) in developed regions were conducted according to the technical manual. However, in underdeveloped regions, some modifications were needed, i.e. the medical consultations, medical checkups and health education undertaken by a nurse in charge and not always conducted by a doctor; and, the services were conducted at the village meeting halls. Also, the reminders were delivered through socialization by local governments and direct invitation by team members when they met the participants on the roadway or in the neighborhood around the participantsâ€™ homes.Conclusion: CDMP cannot fully be implemented in underdeveloped regions and some modifications were needed according to local conditions.
A 3-days old infant with neonatal soft tissue sarcoma: a case report
Authors: Sidabutar Dwi Feris , Prasetyo Agung Aji
Published: February 2022

Background :The incidence of sarcomas occurs in less than 1% of all malignant tumors but sarcoma is the cause of 2% of total cancer deaths. Based on the National Registry the incidence of neonatal sarcomas is 2.6 per million live births.Case Description : A baby girl aged 3 days, complaining of a mass on the patient's left thigh since birth. the mass was large from birth and there was only one on the left thigh. In the prenatal history, the mother and baby with routine ANC history to the midwife, and never having a control with an obstetrician, the mother was not sick during pregnancy and took medication during pregnancy outside of a doctor's prescription. In the perinatal history, the baby was born to mother G1P1A0, gestational age at term, was born by cesarean section, with birth weight 2800 grams, was born crying, active movement, reddish color, vomiting (-) genitalia (+) anus (+)Conclusion : Soft tissue sarcomas (STS) require proper diagnosis and management. The results of rhomboid flap in the tumor resection area are better than skin grafts of similar shape and location and provide cosmetic advantages with very few complications.
Right hepatic artery pseudoaneurysm after choledocoduodenostomy: a case report
Authors: Prabowo Erik , Fuadi Ahmad Fathi , Santoso Antonius Gunawan
Published: February 2022

Background: Pseudoaneurysm of right hepatic artery is a rare complication after bile duct injury (BDI) repair. An unidentified rupture of pseudoanuerysm will lead to mismanagement of this fatal complication. Massive haemorrhage can present and causes high mortalityCase Description: We report a 60-year-old female who suffered jaundice and massive upper gastrointestinal bleeding two weeks after cholodocoduodenostomy bypass surgery in rural hospital. That procedure was done because of BDI after laparoscopic cholecystectomy. Embolisation was carried out after identifying an pseudoaneurysm of right hepatic artery to stop bleeding. Bleeding was transiently stopped, and rebleeding occurred several weeks later. Surgery was performed because of repeated bleeding after third embolization in Kariadi hospital. Ruptured pseudoaneurysm to choledocoduodenostomy anastomosis was found. Pseudoaneurysm was resected and right hepatic artery was sutured. Choledocoduodenostomy was closed. Continuity of biliary tract was maintained by re-reconstruction choledoco-jejunostomy roux n Y. Upper gastrointestinal bleeding symptom was disappeared, and bilirubin level was returned to normal at outpatient follow up after operation.Conclusion: This patient had a hemobilia because of ruptured right hepatic artery pseudoaneurysm. Triad Quincke which consist of right upper quadrant pain, jaundice and upper gastrointestinal bleeding, occurs in 30% of patient with hemobilia. This sign of hemobilia after biliary tract procedure must be managed quickly and accurately. Angiography is main diagnostic procedure. Arterial embolisation is first line intervention to stop the bleeding. Surgery is preserved in case where rebleeding occurs. Good anatomical knowledge can prevent this complication.