bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessing efficacy and tolerability of lamotrigine (Sazar®) in therapy of female idiopathic generalized epilepsy: a multicenter study
Authors: Barkhatov M. V. , Bakhtin I. S. , Belyaev O. V. , Yamin M. A.
Published: January 2022

Background. Idiopathic generalized epilepsy (IGE) comprises 15–20% among all types of epilepsy. However, specifics of administration for lamotrigine in IGE in the Russian Federation remain poorly investigated, especially in female subjects.

Objective: to assess efficacy and potential adverse events (AEs) in girls and females with preserved childbearing potential and verified IGE upon initial treatment with lamotrigine, upon switching to lamotrigine from a first-antiepileptic drug (AED) that provided no full seizure control and/or was coupled to AEs, as well as while introducing lamotrigine as an adjunctive therapy in case a monotherapy achieved no therapeutic efficacy.

Material and methods. There were enrolled 54 female patients aged 4 to 40 years (mean age 19.3 years, median 11 years). After verifying IGE, patients received a monotherapy with lamotrigine. In case a patient received a first monotherapy course, but achieved no full seizure control and/or was coupled to AEs due to administered AED, lamotrigine was prescribed as a second AED followed by a potential for further switch to a second monotherapy.

Results. It was found that a first monotherapy resulted in the maximum remission rate in patients with isolated generalized tonic-clonic seizures. Lamotrigine efficiently suppressed EEG epiactivity, with observed EEG-remission in 8 out of 16 (50%) patients. While being administered as a second monotherapy, lamotrigine resulted in remission in 87.5% patients. A combination therapy with lamotrigine was required in 22 cases. Most commonly, it was combined with levetiracetam (15 patients). While administering a dual therapy with lamotrigine, remission was observed in 9 patients receiving basal therapy with this drug, as well as 3 and 1 patients receiving valproic acid and topiramate, respectively. Six more patients were observed to demonstrate more than 50% improvement (5 subjects in levetiracetam group and 1 in ethosuximide group).

Conclusions. The study demonstrated high efficacy of administered lamotrigine as a first monotherapy as well as a second monotherapy and a combination therapy in girls, adolescent girls and females with IGE. Lamotrigine resulted in no serious AEs that might lead to its cancellation.
Medicines for people. Myths and reality
Authors: Petrukhin A. S.
Published: January 2022

The letter raises the issue of myths existing among the general population about the harmfulness of synthetic medicines. The problems of drug provision, the lack of vital antiepileptic drugs on sale, frequent changes in the prescription forms are touched upon. The reasons for the low efficiency of domestic generics are indicated, an inconvenient form of their release is noted. The author emphasizes how important it is for a doctor to take into account the individual characteristics of a patient when choosing drug therapy.
Intersubjective Connections and their Role in the Process of Professionalization of Foreign Language Teaching in Law Schools
Authors: Biryukova M. A.
Published: January 2022

The problem of influence of intersubjective connections on the quality of foreign language teaching in law schools in the Russian Federation has attained a new level. Changes in the social and cultural environment caused by coronavirus pandemic affect all the areas of human activities including intersubjective connections. The compelling transition to distance learning of future lawyers does not allow to implement to the full extent the traditional components of higher education, including feedback and pedagogical control.That is why assessment of the role of intersubjective connections in foreign languages teaching becomes increasingly important. Hence, the issue of interaction between subjects and objects of teaching foreign languages in electronic educational environment might be viewed as a present-day challenge. It undoubtedly affects to a certain extent the professionalization of foreign languages teaching as well as effectiveness and quality in the ambiance of distance learning of a legal university
English Legal Terms Containing Adjectives
Authors: Degtyaryova Е. A.
Published: January 2022

The article deals with English legal terms formed with the help of adjectives. The author points to the relevance of adjectives in the formation of legal terms due to their evaluation capacity which is an important component of legal concepts. The article reviews the most productive affixes used for the formation of adjectives. It identifies the usage frequency of legal terms with simple adjectives, terms with adjectives in the comparative and superlative degrees of comparison, attributive prepositional and postpositional word-combinations.The paper contains a classification of the legal terms in question according to their structure. Special attention is paid to word-combinations with connotative meaning. The author gives examples of connotative legal terms with adjectives including figurative connotative lexical units and connotative phrases with evaluation components. The article offers a set of exercises helping law students to understand the peculiarities of usage and functioning of legal terms with adjectives as a component.
Phraseology in the Legal English Discourse
Authors: Kalinovskaya V. V.
Published: January 2022

The article is devoted to the peculiarities of the functioning of phraseological units in legal discourse. Phraseological units are an important part of many legal texts, for example, court decisions. English phraseological units in legal discourse play a very important role: they denote legal concepts, carry information of a cultural and legal nature, have a significant impact on the recipient of information. The study of phraseological units in this area contributes to a deeper understanding of representatives of different cultures and speakers of different languages. Phraseological units are language intermediaries between representatives of different cultures. The research material includes phraseological units selected from the English-speaking corpus. The language of legal discourse is peculiar, and the use of phraseological units in it is determined not only by linguistic, but also by extralinguistic factors. Depending on the type of the text and its stylistic coloring , phraseological units will perform different functions and carry different meanings.
Propiedades psicométricas del Dating Violence Questionnaire – R en mujeres de Ecuador
Authors: Cherrez-Santos Ana Valeria , Alulema-Sanchez Santiago , Juarros-Basterretxea Joel
Published: January 2022

La violencia en la pareja (IPV) es un problema socio-sanitario de gran relevancia en el contexto ecuatoriano. Sin embargo, no existen escalas cuya fiabilidad y validez para la medición de la prevalencia de la IPV haya sido demostrada en este contexto. El objetivo de este trabajo fue analizar las propiedades psicométricas del Dating Violence Questionnaire – R (DVQ – R; Rodríguez-Diaz et al., 2017) en población ecuatoriana. La muestra estuvo compuesta por 524 mujeres de entre 18 y 30 años que tenían o habían tenido una pareja del sexo opuesto. El ajuste del modelo a los datos se evalúo mediante análisis factorial confirmatorio y la fiabilidad de las escalas se estimó mediante el índice omega ordinal. El modelo de medida originalmente propuesto por Rodríguez-Díaz et al. (2017) tuvo un buen ajuste a los datos (χ2 = 280.705, gl = 160, p ≤ .001, CFI = .976, RMSEA = .038 90% I.C. [.030, .045]). Además, se obtuvieron índices de fiabilidad apropiados para todos los factores (ω = .79 - .94). El DVQ – R es un instrumento válido y fiable para la medición de la victimización en mujeres jóvenes en el contexto ecuatoriano.
Depresión, ansiedad y estado nutricional en adolescentes de la ciudad de Temuco
Authors: Cofré Alfonso , Gallardo Gabriel , Maripillan Lissette , Sepúlveda Lizbeth , Parra Matías
Published: January 2022

La adolescencia es una etapa de cambios biológicos, psicológicos y sociales. Estos cambios constituyen un posible espacio de vulnerabilidad para presentar trastornos de salud mental. Esta investigación tuvo como objetivo analizar la relación entre depresión, ansiedad y estado nutricional en adolescentes. Participaron 61 sujetos pertenecientes a la ciudad de Temuco, Chile. Se utilizó el instrumento BDI-II para medir niveles de depresión y BAI para medir niveles de ansiedad, finalizando con el cálculo de IMC. Presentar un IMC >24,9 es indicador de sobrepeso y un IMC mayor a 29,9, de obesidad. Los resultados obtenidos mostraron que el 83,6% de los participantes presentó síntomas depresivos, en el cual, el 58,8% obtuvo un IMC> 24,9. El 88,5% presentó sintomatología ansiosa, donde el 59,3% alcanzó un IMC> 24,9. Se encontró una alta correlación entre depresión y ansiedad en contraste con las variables de salud mental e IMC donde no se encontraron correlaciones significativas.
The Process of Becoming a Political Personality and the Factors That Determine It (the experience of the German Chancellor Otto von Bismarck)
Authors: Baev Valery G. , Meshcheryakova Svetlana V.
Published: January 2022

The proposed article attempts to reveal the process of becoming a politician, and not merely an ordinary politician, but one who develops and imposes a large-scale policy that independently determines the options for the development of his country: the creator of the Second Empire in Germany, the great statesman Otto von Bismarck. The goal of the study was to analyze the legal, political, and psychological factors that contributed to the rise of the first civil servant in the empire. The life and fate of each person are in the crosshairs objective and subjective circumstances interact. The role of external, otherworldly forces, colloquially called chance, is also not to be excluded in any such rise. Contrary to popular belief, people are not born clean slates at all. Instead, each bears the stamp of parental education and the personality and health imposed by the genetics of distant ancestors. From the enormous variety of factors, experiences, and relationships within which a personality is formed, the authors of this study chose reference points that, in their opinion, contributed most to forming the contours (or images) of Bismarck as an outstanding politician. These include the aspects of his character that absorbed and reflected the influence of his ancestors and parents (most of all, his mother), as well as the principles that prevailed in the German educational system and the public service of Germany. In this objective review, the subjective (personal) properties of the applicant for the highest administrative position in the state were acutely manifested: a hypermotivation to acquire power and the ability to recognize the importance of representing state interests for themselves.

In their conclusions, the authors relied on collections of Bismarcks letters, on his parliamentary and political speeches, and other documents that accompanied his life. They also relied upon their own interpretation of the distant events of Bismarcks life and times. The study thus acquired an intersectoral character. Although the historical subtext of our research is obvious, the proposed material will also be of interest to modern politicians.
Information and Analytical Activities of the Prosecutor’s Office: On the Issue of Functional Status
Authors: Khatov Eduard B.
Published: January 2022

This article analyzes the information and analytical activities of the Russian Prosecutors Office, and in doing so highlights a number of its characteristic features. The author, relying on doctrinal and historical research relating to the information function of the state, analyzes various aspects of the Prosecutors Office. The areas reviewed include: the Constitution of the Russian Federation and foreign and domestic legislation concerning the prosecutors office. Taking into account the progressive informatization of various spheres of public relations, analyzing the practice of work, and comparing debatable objective positions regarding the allocation of its other functions, the author concludes that there is a possibility of giving the studied type of prosecutors activity a functional status and the need for appropriate adjustments to the law.
Prevalencia e incidencia de hipertensión arterial en Perú: revisión sistemática y metaanálisis
Authors: Ruiz-Alejos Andrea , Carrillo-Larco Rodrigo M , Bernabé-Ortiz Antonio
Published: January 2022

Objetivo. Determinar la prevalencia e incidencia de hipertensión arterial, y la prevalencia de diagnóstico previo de hipertensión arterial (autorreportado) en población general adulta del Perú. Materiales y métodos. Revisión sistemática y metaanálisis de estudios epidemiológicos disponibles en LILACS, EMBASE, MEDLINE y Global Health. Se incluyeron estudios que siguieron un muestreo aleatorio de la población general adulta. El tamizaje y estudio de los manuscritos fue realizado por dos investigadores de forma independientemente. Se hizo metaanálisis de efectos aleatorios para cuantificar la prevalencia e incidencia global. Los manuscritos fueron evaluados con la escala Newcastle-Ottawa para evaluar el riesgo de sesgo. Resultados. Se tamizaron 903 artículos, y se incluyeron 15 manuscritos para prevalencia, 8 para prevalencia de diagnóstico previo, y 4 para incidencia de hipertensión. El metaanálisis mostró una prevalencia agregada de hipertensión de 22,0% (IC 95%: 20,0% - 25,0%; I2=99,2%). Esta prevalencia fue menor en estudios nacionales [20,0% (IC 95%: 17,0% - 22,0%; I2=99,4%] que en subnacionales [24,0% (IC 95%: 17,0% - 30,0%; I2=99,2%]. La prevalencia global de diagnóstico previo de hipertensión fue 51,0% (IC 95%: 43,0% - 59,0%; I2=99,9%). La incidencia global fue de 4,2 (IC 95%: 2,0 – 6,4; I2=98,6%) por cada 100 personas-año. Los manuscritos estudiados no presentaron alto riesgo de sesgo. Conclusiones. Nuestros hallazgos muestran que uno de cada cinco peruanos tiene hipertensión, y que aparecen cuatro nuevos casos por 100 personas en un año, además solo la mitad de los pacientes hipertensos tienen el diagnóstico previo de su condición.
Factores asociados a letalidad por COVID-19 en un hospital de la región Cajamarca en Perú
Authors: Anyaypoma-Ocón Walter , Ñuflo Vásquez Sandra , Bustamante-Chávez Hugo Cesar , Sedano-De la Cruz Edyson , Zavaleta-Gavidia Víctor , Angulo-Bazán Yolanda
Published: January 2022

Objetivo. Identificar las características clínicas y epidemiológicas relacionadas a la letalidad en pacientes hospitalizados por COVID-19 en el Hospital Simón Bolívar de Cajamarca, durante junio-agosto de 2020. Materiales y métodos. Cohorte retrospectiva, con información recolectada de historias clínicas y sistemas oficiales de vigilancia epidemiológica (NOTIWEB, SISCOVID y SINADEF), sobre pacientes hospitalizados con diagnóstico confirmado de COVID-19. Se recolectó información sobre factores sociodemográficos y clínicos, considerando como desenlace el egreso (fallece/sobrevive) y los días de hospitalización. Resultados. La tasa de letalidad intrahospitalaria fue 39,6%, encontrándose diferencias significativas entre el tiempo de hospitalización y la condición de egreso en las personas mayores de 60 años (p0,001). La edad mayor de 60 años (HR: 2,87; IC95%: 1,76-4,68),) solicitud de cama UCI no atendida (HR: 3,49; IC95%: 2,02-6,05), saturación de oxígeno menor a 80% al ingreso (HR: 2,73; IC95%: 1,35-5,53) y el uso de ivermectina (HR: 1,68; IC95% 1,06-2,68) fueron factores asociados a letalidad. El modelo de Machine Learning (ML) elegido consideró que las variables con mayor importancia fueron la saturación de oxígeno, la edad mayor de 60 años, tiempo de hospitalización y tiempo de síntomas. Conclusión. Los factores que podrían incrementar la letalidad en pacientes hospitalizados por COVID-19 fueron la edad, saturación de oxígeno menor a 80%, uso de ivermectina en la terapéutica hospitalaria y la solicitud no atendida de camas UCI. Futuros estudios con una mejor representatividad podrían confirmar estas posibles relaciones a nivel regional o nacional.
Paracoccidiodimicosis sistémica con compromiso del apéndice cecal en un niño: reporte de caso
Authors: Luna-Vilchez Medalit , Chiara-Chilet Christian , Maquera-Afaray Julio , Portillo-Alvarez Diana , López José W.
Published: January 2022

La paracoccidioidomicosis es la micosis sistémica más prevalente en Latinoamérica. En niños la presentación clínica más frecuente es la forma juvenil o aguda/subaguda, que compromete principalmente los ganglios linfáticos y en menor proporción los órganos gastrointestinales. Presentamos el caso de un paciente de 10 años, sin comorbilidades, con dolor agudo en fosa iliaca derecha; además de historia de un mes de evolución de diarrea, fiebre, pérdida de peso e hipereosinofilia. Fue diagnosticado de apendicitis aguda secundaria a un cuadro de paracoccidioidomicosis sistémica, mediante histopatología del apéndice cecal y ganglios mesentéricos. Tuvo respuesta favorable al tratamiento con anfotericina B liposomal. A pesar de que la paracoccidioidomicosis sistémica con compromiso del apéndice cecal es infrecuente, debe considerarse como parte de los diagnósticos diferenciales en niños con linfadenomegalias generalizadas y procedentes de áreas endémicas.
Evaluación de la respuesta humoral inducida por la vacuna BBIBP-CorV mediante la determinación de anticuerpos neutralizantes en personal sanitario peruano
Authors: Soto Alonso , Charca-Rodríguez Flor De María , Pareja-Medina Mario , Fernandez-Navarro Manuel , Altamirano-Cáceres Karina , Sierra Chávez Elizett , Raraz-Vidal Jarvis , Cabezudo-Pillpe Nestor , Velarde-Rodríguez Melissa , Alcántara-Díaz Andrés
Published: January 2022

Objetivo. Determinar el título de anticuerpos frente al dominio de unión al receptor (RBD) de la proteína espiga (S) en personal de salud entre la 4.ª y 12.ª semana luego de haber recibido la vacuna BBIBP-CorV (Sinopharm). Materiales y métodos. Se incluyeron 168 trabajadores de salud de dos hospitales de la región, quienes cumplían el esquema completo con vacuna de Sinopharm, y se realizó la medición de anticuerpos en suero mediante la prueba Elecsys® Anti-SARS-CoV-2. Resultados. Todos los participantes desarrollaron anticuerpos frente al dominio RBD. El valor mínimo fue de 1,78 U/mL. En 70 (41,7%) participantes se encontraron niveles iguales o por encima de 250. La media geométrica fue de 82,6 (IC 95% 67,8-100,6). Las mujeres presentaron un mayor nivel de anticuerpos. El grupo de participantes en los que se midieron anticuerpos entre las semanas 4 y 7 posvacunación mostró niveles de anticuerpos significativamente mayores que los pacientes cuyas determinaciones fueron realizadas entre las 10 y 12 semanas posvacunación. Entre los pacientes con antecedente de COVID-19, los niveles de anticuerpos se encontraron en cifras iguales o por encima de 250 U/mL en el 88% de casos, en comparación con 6% entre aquellos sin antecedente de COVID-19, (p0,001). Conclusión. Todos los participantes inmunizados con la vacuna BBIBPCorV presentaron positividad a anticuerpos frente al RBD de la proteína S del SARS-CoV-2. Es necesario evaluar la correlación entre la magnitud de los títulos y la protección frente a COVID-19 y el tiempo de protección conferido por la vacuna.
Asociación entre la necesidad de cuidados paliativos y enfermedades crónicas en pacientes atendidos en un hospital peruano
Authors: Pinedo-Torres Isabel , Intimayta-Escalante Claudio , Jara-Cuadros Diego , Yañez-Camacho Walter , Zegarra-Lizana Paolo , Saire-Huamán Reynaldo
Published: January 2022

Objetivos. Evaluar la asociación entre las enfermedades crónicas (EC) y la necesidad de cuidados paliativos (NCP). Materiales y métodos. Se realizó un estudio transversal analítico en un hospital peruano durante el 2019. Se incluyó a pacientes hospitalizados con EC y se excluyó gestantes y a los hospitalizadosen unidades críticas. En la evaluación de la NCP se aplicó el instrumento SPICT-ESTM, adicionalmente se evaluaron características sociodemográficas y clínicas. La fuerza de asociación se calculó con regresiones de Poisson con varianza robusta para estimar razones de prevalencia crudas (RP) y ajustadas (RPa) porconfusores. Resultados. Se evaluó 172 pacientes, la media de edad fue 61 años, donde el 54,7% eran varones y 123 pacientes tenían NCP. En el modelo crudo se encontró asociación con tener enfermedad cerebrovascular (RP: 1,23; p=0,028), cualquier tipo de cáncer (RP: 1,38; p0,001), cardiopatías (RP: 1,29; p=0,007), nefropatía (RP: 1,42, p0,001) y enfermedad de Alzheimer (RP: 1,42; p0,001). La asociación se mantuvo en la mayoría de EC evaluadas en el modelo ajustado, excepto para cardiopatía (RPa: 1,11; p=0,320). La fuerza de asociación fue menor en el caso de diabetes mellitus (RP: 0,78; p=0,044). Conclusión. La NCP en pacientes con enfermedades crónicas hospitalizados es alta y más frecuente en pacientes con cáncer, enfermedad cerebrovascular, problemas renales y enfermedad de Alzheimer. Los programas de cuidado de pacientes con diabetes mellitus pueden disminuir la NCP.
Seguridad de las vacunas contra la COVID-19
Authors: Chaparro Mérida Nataniel Aldo , Samper Dayany Moreno , Franco Lacato Alex Omar
Published: January 2022

El desarrollo y producción de vacunas seguras y eficaces contra la enfermedad por coronavirus 2019 (COVID- 19) ofrece la esperanza para el control de la pandemia actual. Los eventos adversos posteriores a la inmunización son respuestas indeseadas o acontecimientos involuntarios que siguen a la vacunación, y que deben ser cuidadosamente vigilados, ya que todas las vacunas, incluyendo las desarrolladas contra el SARSCoV- 2, requieren cumplir con los criterios de seguridad para su administración en humanos. Se recopiló la información de la base de datos de PubMed/Medline durante los meses de agosto de 2020 a noviembre de 2021. La mayoría de los eventos adversos identificados en los ensayos clínicos fueron leves o moderados; sin embargo, se identificaron eventos trombóticos asociados a algunas vacunas basadas en vectores virales contra la COVID-19 en estudios de seguimiento, aunque se requiere la conclusión de los distintos estudios en curso y vigilancia poscomercialización para determinar todos los posibles eventos adversos y de especial interés.
Application of quality function deployment in defense technology development
Authors:   , Forster Cornejo Estrella de Maria , Hrebien Leonid
Published: January 2022

Introduction. As advances in aviation technology take place, the research community recognizes, and the operator demands that the progress in technology be integrated with the human component of the same, the aircrew. Integrative programs are primarily concerned with three sub-systems: the operator, the aircraft, and the cockpit. To accomplish their integration, a "dialogue" between the various disciplines addressing these aspects of the weapon system is indispensable. Such dialogue is theorized to be possible via Quality Function Deployment (QFD). QFD emphasizes an understanding of the relationships between the requirements of the aircrew and the technology the research and engineering community provides. In establishing these relationships, program management concerns such as need, applicability, affordability, and transition of the technology are addressed. Procedures. QFD was incorporated in a Performance Methodology (PMM). This methodology associates a particular technology's Measures of Performance (MOP) and the overall weapon system's Measures of Effectiveness (MOE) to which it is applied. Incorporation of QFD in the PMM was hypothesized to result in an improved PMM (Q-PMM) that would address both, the aircrew's interests and those of program management. Both methodologies were performed. The g-ensemble was selected as the technology of interest. The Standard and Combat Edge designs were examined for comparison purposes. Technology MOPs were ranked in order of importance in accordance to both the PMM and its proposed improvement, the Q-PMM. These methodologies were then evaluated by way of an experiment in the human centrifuge. This experiment was to answer two questions: Is there a relationship between the technology's MOP and the aircraft's MOEs? Given a MOP-MOE relationship, is there a difference between the two ensembles? Findings. The Q-PMM was superior to the PMM in addressing customer's requirements. The Q-PMM was superior to the PMM in addressing program management concerns. The Q-PMM provided an improvement in defining the MOPs that would best describe the overall system MOEs. Both, MOP-MOE associations and a basis of comparison between the two ensembles were elucidated. Conclusion. The findings demonstrated QFD to be an effective approach to defense technology development.
The Challenge of Achieving Zero Trust Remote Access in Multi-Cloud Environment
Authors: Chimakurthi Venkata Naga Satya Surendra
Published: January 2022

Zero-trust security models and architectures have recently increased in adoption due to several variables, such as the widespread use of off-premises cloud technologies, variety in IT devices, and diffusion in the Internet of Things (IoT). Users, devices, apps, and networks are all assumed to be untrustworthy in this approach, which is built on the idea of various tiers of Trust and authentication. Cybersecurity paradigms are developing, and the term "zero trust" describes the shift from static network perimeters to protecting people, things, and resources. Economic and enterprise architecture and processes can be designed using zero trust principles. In the idea of zero Trust, assets or user accounts are thought to have no implicit confidence because of their physical or network location (Internet vs local networks) or asset ownership (enterprise or personally owned). Authentication and authorization must be conducted before a connection to an organizational resource can be established. There are many different types of Cloud, including several public, private, hybrid, and on-premises. For data centers, a multi-cloud deployment strategy includes many different public cloud service providers instead of relying on a private cloud or on-premises architecture. Hybrid multi-cloud is a multi-cloud implementation that incorporates all public and private clouds and on-premises technology. This paper discusses the zero-trust security model for multi-cloud environments and applications and the obstacles to implementing it.
Responsabilidad patrimonial sanitaria por error en la identificación de neonatos Comentario a la Sentencia de Juzgado de lo Contencioso Administrativo de Pamplona/Iruña (Sección 3) de 6 de septiembre de 2021
Authors:   Universidad de Castilla-La Mancha, GONZÁLEZ CARRASCO MARÍAI CARMEN
Published: January 2022

El comentario analiza la identificación y la valoración del daño resultante de la incorrecta identificación de neonatos con entrega a progenitores distintos de los biológicos, así como el valor de los protocolos de seguridad en relación el régimen de responsabilidad patrimonial sanitaria y discute el criterio de imputación causal consistente en la pérdida de oportunidad en relación con la argumentación de la Sentencia de Juzgado de lo Contencioso Administrativo de Pamplona/Iruña (Sección 3) de 6 de septiembre de 2021.
Heating Systems for Small, Scattered and Remote Residential Areas in the Tibetan Plateau
Authors: Sun Ye , Zhao Bo
Published: January 2022

This paper targets the heating needs of small, scattered and remote residential areas in the Tibetan Plateau. Considering the severe cold, high altitude, high radiation intensity, long sunshine duration and large temperature difference between day and night, etc. in this region, through the comparative analysis of the performance of heating terminals and heat source systems, it is proposed in this paper that the multi-energy complementary intelligent energy and clean heating approach can effectively reduce operating and maintenance costs, mitigate pollutant emissions and improve the indoor heating environment. Then, with Pagri Town, Shigatse City, Tibet as the pilot area, the multi-energy complementary smart energy and clean heating approach (with solar energy storage heat pump as the heat source + radiators as the heating terminal) was actually applied in the project. Through analysis of the indoor and outdoor temperature changes, electricity consumption and operating costs during the heating period of the pilot project, it is finally concluded that the heating model with solar energy storage heat pump as the heat source + radiators as the heating terminal is a rational choice for the heating systems for small, scattered and remote residential areas in the Tibetan Plateau.
An Analysis of the Coupling Between Temperature and Thermal Stress of Disc Brakes Based on Finite Element
Authors: Wen Min
Published: January 2022

Disc brakes have been more widely used in recent years due to its many merits such as fast heat absorption and dissipation, and resistance to water fade. Since it’s difficult to describe the failure of brakes under complex working conditions in only a few times of thermal-structural coupling simulations, this paper analyzed the coupling between temperature and thermal stress of disc brakes under multiple continuous braking conditions. At first, a 3D model of bus disc brake was built in ABAQUS, and its braking motion and dynamic parameters, heat flux density, convective heat dissipation coefficient, heat flux distribution coefficient, and other thermodynamic parameters were calculated. Then, the numerical simulation of the temperature field of disc brake and the coupling analysis of thermal stress under different braking conditions were completed. At last, experimental results gave the analysis results of the temperature distribution characteristics of brake disc surface, and the comparison and demonstration of the finite element analysis were conducted.
Heat Transfer Analysis of Plate Fin Heat Sink with Dimples and Protrusions: Investigation of New Designs
Authors: S N Sharath Kumar , S Sathish , H R Purushothama
Published: January 2022

Numerous works have been carried out in the design and analysis of Heat Sink, however hardly any work have been reported with studies on dimples and protrusions being added to the heat sink geometries. This paper aims to find the worthiness for addition of dimples and protrusions to the common plate fin heat sink geometries for heat transfer enhancement. Analysis was carried out in forced convention environment for 9 different velocities computationally for 12 heat sink geometries at constant heat flux boundary condition applied to base of heat sink. Decrease in base temperature and thermal resistance of heat sink was considered as the performance factors. Further these computational results were validated experimentally. The results obtained from computational analysis were in good agreement with experimental results. The research outcome show that addition of dimples has proved its worthiness at slightly higher velocity regime with thermal performance being increased for a dimpled heat sink as compared to non-dimpled heat sink. Therefore, currently developed dimpled heat sinks can be a potential model that can be used in forced convection environment for better thermal performance and economy.
Dual Solutions of EMHD Nanofluid at Stretching Sheet with Mixed Convection Slip Boundary Condition
Authors: Jauhri Shefali , Mishra Upendra
Published: January 2022

In this paper stagnation boundary layer flow of nanofluid with mixed convection heat and mass transfer with Electrical Magneto Hydrodynamic (EMHD) effects over a second-order momentum slip boundary condition have been mathematically analysed. The governing equations are transformed by similarity variable and the problem becomes coupled third-order nonlinear coupled differential equations. We use fourth-order Runge Kuta method and shooting technique to find the solution. The effect of second-order momentum slip condition with linear thermal slip condition has determined. Variation of all nano energy conversion parameters depends on different factors has shown graphically. Some of the parameters possesses dual solution at different values of second-order velocity slip parameter (β1&β2).
Evaluation of TiO2 Nanoparticles as an Additive in Diesel-n-Butanol - Bombax Ceiba Biodiesel Blends for Enhance Performance and Emissions Control of a CI Engine
Authors: Sandhi Raja Sekhar , Chebattina Kodanda Rama Rao , Sambana Narayana Rao , Vadapalli Srinivas , Pullagura Gandhi , Pathem Uma Chaithanya
Published: January 2022

In this study, additions of Titanium dioxide nanoparticles into diesel- Bombax ceiba methyl ester (BCME) and n-butanol (C4H9OH) and the impact of nano particles on the emission and performance characteristics of a diesel engine were studied experimentally. The n-butanol in fuel samples significantly influenced the physicochemical properties of the blends. The TiO2 nanoparticles were added at different concentrations of 30, 60, and 90 ppm. The ratio of 1:4 TiO2: QPAN 80 was observed to deliver maximum possible stability in biodiesel. In addition, more oxygen in n-butanol and nano additives minimize environmental air pollution. The experiments employed Diesel, B20, B20Bu10, B20Bu10T30, B20Bu10T60, and B20Bu10T90 blends using the four-stroke, direct injection diesel engine with single-cylinder. The experimental results showed that adding 60 ppm TiO2 nano particles in B20Bu10 improved thermal efficiency by 8.36% and reduced the brake-specific fuel consumption by 21.6% compared to B20Bu10. The B20Bu10T60 blend reduced the carbon monoxide (CO) and unburned Hydrocarbon (UHC) emissions by 22.91% and 12% correspondingly compared with other blends. The above results demonstrated the optimal improvement in whole engine performance characteristics and fewer environmental pollutants at a dosage level of 60 ppm TiO2 nano particles.
Thermal Comfort Optimization in an Electric Vehicle
Authors: Jose Sherin Sam , Chidambaram Ramesh Kumar
Published: January 2022

In automobiles, the demand for HVAC has been rising for decades and the key variables that affect the thermal comfort in a car were identified as air velocity, temperature, radiant temperature, and relative humidity. Thermal comfort estimation in a vehicle depends on the transient behavior of the cabin space and boundaries. The predicted mean vote (PMV) and predicted percentage of dissatisfied (PPD) are the available methods to describe and optimize thermal comfort in cabin space. In this paper, the cabin thermal comfort of a minivan was analyzed for reduction of energy consumption with the help of experimental and numerical simulation. Using CFD simulation and validation with experimental data, the flow dynamics inside a vehicle cabin is evaluated based on air velocity, temperature, and comfort indices. With some error for the extreme planes, a strong agreement was reached between the experimental values and the CFD model. With the reduction in the air velocity from 2.3 m/s to 1.3 m/s, the average power required to run the blower can be reduced by 43%, providing an advantage of reducing the capacity of the compressor. The higher PPD values were observed on the walls of the cabin and at the outlet of the AC vents.
The Electromagnetic Wave Absorbing Property of Dual-Layer Cement Matrix Composites Based on the Principle of Electromagnetic Energy - Thermal Energy Conversion
Authors: Zhang Zuoqun , Yang Chaoshan , Cheng Hua , Zhou Longlong , Ren Junru , Zhu Yuhao
Published: January 2022

Based on the application of stealth technology in actual engineering projects, and according to the theory that when electromagnetic waves (EMW) pass through different wave absorbing materials, they will undergo resistance loss, dielectric loss, and magnetic loss, and the electromagnetic energy will be converted into thermal energy, this paper designed and developed a dual-layer EMW-absorbing Cement Matrix Composites (CMC) combining with the principle of impedance matching, and proposed to take cement paste mixed with expanded perlite as the matching layer of the newly developed material, and aggregate and nanomaterials as its wave absorbing layer. The aggregate was prepared by mixing 15wt.% 38μm Fe3O4 powder and 10wt.% 500nm SiC powder into the clay powder to produce cement raw pellets and calcine them at 1190℃, the fabricated aggregate has obvious dielectric loss and magnetic loss to EMW, and its crushing resistance strength can reach 13.7MPa. For the dual-layer test pieces made of the prepared aggregate and 2wt.% Conductive Carbon Black (CCB), within 8-18GHz frequency band, the bandwidth with a reflectivity lower than -10db reached 9.5GHz, the bandwidth with a reflectivity lower than -12db reached 7.55 GHz, and its maximum reflection loss reached -19.56db. In addition, the prepared CMC exhibited good mechanical properties, and its compressive strength reached 50.7MPa at the age of 28d.
Colorectal Intussusception Due to Tubulovillous Adenoma in the Sigmoidorectal Junction: A Case Report
Authors: Mirhashemi Seyed Hadi , Nakhaei Mobin , Ebrahimian Manoochehr
Published: January 2022

Adult intussusception is a rare disease with various clinical presentations and can cause grave surgical problems. The condition is associated with malignant and benign leading points in adults, unlike in children who mostly experience the latter. The colonic intussusception type can be more malignant than the enteric type, especially in distal parts of the colon. Sigmoidorectal intussusception is less common in adults; it usually presents as bowel obstruction or lower gastrointestinal bleeding. We reported a case of a middle-aged woman with sigmoidorectal intussusception who was treated by transrectal endoscopic surgery.
Severe Exposure Keratopathy Leading to Sterile Corneal Perforation Treated Successfully by Lamellar Corneal Patch Graft: A Case Report
Authors: Ansari Iman , Abbasi Hamed , Mohammadzadeh Amir , Hassanpour Kiana
Published: January 2022

We reported a case of corneal perforation due to longstanding exposure keratopathy treated successfully with lamellar corneal patch graft, conjunctival flap, and lateral tarsorrhaphy. A 75-year-old male presented with ocular pain and decreased visual acuity in his right eye since 2 weeks ago. On external examination, lagophthalmos in the right eye was evident. Visual acuity was hand motion on slit-lamp examination. 2×3 mm perforated area in the right cornea accompanied by adjacent corneal melting and diffuse punctate epithelial keratopathy were observed. The anterior chamber was flat. Intraoperatively, a 7×2.5 mm-diameter corneal patch graft was fashioned manually; its thickness was reduced and placed over the perforated area, successfully sealed the cornea, a partial bipedicle conjunctival flap was also applied over the graft, and lateral tarsorrhaphy was performed. Four weeks after surgery, Corrected Distance Visual Acuity (CDVA) improved to Counting Finger (CF) 20 cm. The lamellar corneal patch graft was intact without a leak, and the conjunctival flap was partially removed retracted. Corneal perforation can occur in patients with severe exposure to keratopathy, and corneal patch graft is a good option when a sizeable corneal perforation (≥3 mm diameter) is not amenable to corneal gluing.
Posterior Cortical Atrophy With Interesting Presentation: Case Reports
Authors: Aghamollaii Vajiheh , Fathollahzadeh Noor Setareh , Bidaki Reza , Agah Elmira
Published: January 2022

Posterior Cortical Atrophy (PCA) is a rare neuropsychiatric syndrome characterized by the dominancy of visuospatial impairments due to bilateral parieto-occipital divesting with the most common pathological changes presented in typical Alzheimer’s Disease (AD). We reported 3 cases with similar diagnoses and interesting manifestations in this study. Gradual onset and progression of visual deficits without underlying ophthalmologic disease accompanied by intact memory and fluent speech and also the presence of simultagnosia, optic ataxia, oculomotor apraxia, dyscalculia, finger agnosia, and environmental disorientation, and the absence of any history of related diseases; all of them strongly suggesting posterior cortical atrophy.
Myeloid Sarcoma Presenting as Rectosigmoid Tumour: A Case Report
Authors: Rahman Mohd. Shafiq , Salleh Norly
Published: January 2022

Myeloid Sarcoma (MS) or extramedullary myeloid tumor is a rare tumor affecting the skin, lymph node, and any part of the body except the bone marrow. MS may present differently depending on the site of involvement. A 61-year-old male with a known case of chronic myeloid leukemia presented to the emergency department of a district hospital with per rectal bleeding for two days. Examination revealed haematochezia with no evidence of rectal tumor. Hyperleukocytosis was noted from the blood investigation. Colonoscopy was performed, which revealed the rectosigmoid tumor. Histopathological examination confirmed the diagnosis of myeloid sarcoma. The patient was subsequently referred to a hematologist in a tertiary hospital for further care. MS may present a diagnostic challenge as it may present nonspecific symptoms depending on the site of involvement. Awareness of this condition is essential; thus, diagnosis and treatment can be initiated earlier.
Delayed Diagnosis of Complete Tracheal Transection
Authors: Ershadi Reza
Published: January 2022

Tracheal injuries are relatively rare; however, their mortality rate is relatively high. Complete disruption of the trachea is extremely rare, and a systematic approach is required for early diagnosis and favorable outcomes. This is a case report of a 17-year-old male admitted to the emergency room after a motor vehicle accident. He was agitated and in respiratory distress with labored breathing and urgently intubated orotracheally. In the first flexible bronchoscopy, the diagnosis of the tracheal transaction was missed. Due to saturation drop and high peak ventilator pressures on the seventh day, the flexible bronchoscopy examination was performed in the operating room. This measure revealed complete tracheal transection in midportion. Neck exploration demonstrated complete tracheal transection. The area was debrided, and primary end-to-end anastomosis was performed. The patient was extubated at the end of the surgery.
Clinical Manifestations of Ataxia-Telangiectasia with Class Switch Recombination Defect
Authors: Esmaeilzadeh Hossein , Askari Aida , Mortazavi Negar , Nabavizadeh Seyed Hesamodin , Alyasin Soheila
Published: January 2022

Background: Elevated serum levels of IgM and recurrent infections, mainly respiratory tract infections, could be the presenting features in some ataxia-telangiectasia (AT) patients, and may initially be misdiagnosed as hyper-IgM (HIgM) syndrome. Class switch recombination (CSR), which is defective in HIgM syndrome, is an important mechanism in the maturation of B lymphocytes to produce different isotypes of antibodies in response to antigen stimulation.
Methods: The clinical manifestations and laboratory findings of 16 cases with low IgA and IgG levels, and normal to elevated IgM levels with CSR defect are reported.
Results: In 16 cases, the median age at onset of the diseases, and median age at the time of the diagnosis were 1 year (interquartile range [IQR] = 1.6), and 4 years (IQR = 3.1), respectively. Two of the patients (12.5 %) died due to respiratory infection. In this study, Out of the studied population, four were male (25%), and 12 were female (75%). Most of the patients had consanguineous parents (81.3 %). All of the patients had ataxia, and 15 patients had telangiectasia (93.8 %), and one of the cases had malignancy (dermatofibroma). Also, 15 patients presented infections (93.8 %). Autoimmunity was seen in three patients (18.8 %). In addition, some of the patients manifested hepatosplenomegaly (31.3 %) and thrombocytopenia (18.8 %). Neurological manifestations, such as visual impairment (12.5 %), epilepsy (6.3 %), and tremor (12.5 %), were also present.
Conclusion: AT patients with HIgM phenotype and CSR defect, compared to other AT patients, may present different clinical manifestations, such as various infections. Considering their manifestations, the management and treatment of these patients are necessary.
Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED): single-centre experience
Authors: Kostyuchenko Larysa , Hrytsiuk Ihor , Romanyshyn Yaryna , Bojko Yarena , Sakovich Inga
Published: January 2022

Background: APECED is a rare autosomal recessive disease, caused by mutations in the AIRE-gene resulting in a failure of T-cell tolerance, clinically characterized by multiple autoimmunopathies. The objective of the study was to determine the clinical and genetic features and consequences of APECED in a single-centre Ukrainian cohort of patients.
Material and methods: Out of five families, eight patients with APECED were included in the study. Family history and clinical information of each patient was collected; laboratory studies aimed at identifying endocrine disorders, other autoimmunity, and infections was done. Genetic testing by NGS was performed in four out of five families. Patients were included in the study after the written informed consent had been signed by their parents/legal guardians.
Results: In most patients, the onset of the disease was noted in childhood with manifestations of hypoparathyroidism and/or candidiasis. Adrenal insufficiency was associated later. Diabetes mellitus, hypothyroidism and hypogonadism were observed as other endocrinopathies. Five of eight patients (62.5%) developed autoimmune hepatitis, two patients suffered from autoimmune lung lesions, and two developed enteropathy. Two patients were diagnosed with brain damage: psychosis and autoimmune encephalitis. All the patients that we examined were homozygous carriers of the Finn major mutation R257X (c.769C> T) of the AIRE gene.
Conclusions: One or two endocrinopathies in combination with recurrent candidiasis are the key to a diagnosis of APECED. Most patients also develop organ autoimmunopathy. The mutation R257X (c.769C> T) of the AIRE-gene is predominant in the population of western Ukraine.
Avaliação de curso de formação interdisciplinar em saúde ocular na intervenção precoce: perspectiva dos participantes
Authors: Nascimento Gabriela Cordeiro Corrêa do , Montilha Rita de Cássia Ietto
Published: January 2022

Este é um estudo com abordagem quali-quantitativa, descritiva-explicativa e longitudinal, realizado entre abril a dezembro de 2018 em Curitiba, Paraná, tendo como objetivo avaliar um curso interdisciplinar de formação em atenção à saúde ocular de crianças com alterações no desenvolvimento ou múltipla deficiência, para profissionais da intervenção precoce. Aplicou-se questionários e grupo focal e foram realizadas análise estatística exploratória-descritiva, aplicação de testes e análise de conteúdo. Participaram 35 profissionais, da saúde e da educação. Os resultados foram organizados nas fases de Reação, Aprendizado e Comportamento e Preditoras de aprendizagem e impacto e correlação entre níveis, a saber: reação positiva ao curso e ao instrutor; aumento da média de aprendizado; impacto no comportamento no trabalho; variáveis motivacionais, de valor instrumental do curso e de uso de estratégias cognitivo-afetivas como preditoras de impacto no trabalho; e correlação positiva reação/impacto. Os relatos do grupo focal reforçam e aprofundam os resultados quantitativos. Destaca-se a importância da realização de cursos interdisciplinares que agreguem saberes e fomentem a colaboração interprofissional.