bluuebunny/crossref_metadata_2025 huggingface dataset:
Polymorphism of Drug Transporters, Rather Than Metabolizing Enzymes, Conditions the Pharmacokinetics of Rasagiline
Authors: Zubiaur Pablo , Matas Miriam , Martín-Vílchez Samuel , Soria-Chacartegui Paula , Villapalos-García Gonzalo , Figueiredo-Tor Laura , Calleja Sofía , Navares-Gómez Marcos , de Miguel Alejandro , Novalbos Jesús , Mejía-Abril Gina , Luquero-Bueno Sergio , Román Manuel , Ochoa Dolores , Abad-Santos Francisco
Published: September 2022

Rasagiline is a selective and irreversible inhibitor of monoamine oxidase type B with neuroprotective effect, indicated for the management of Parkinson’s disease. The aim of this work was to evaluate the impact of seven CYP1A2 alleles and of 120 additional variants located in other CYP enzymes (e.g., CYP2C19), UGT enzymes (e.g., UGT1A1) or other enzymes (e.g., NAT2), and transporters (e.g., SLCO1B1) on the pharmacokinetic variability and safety of rasagiline. A total of 118 healthy volunteers enrolled in four bioequivalence clinical trials consented to participate in this pharmacogenetic study. CYP1A2 alleles were not associated with the pharmacokinetic variability of rasagiline. Patients with ABCB1 rs1045642 G/A+A/A genotypes presented higher area under the curve adjusted by dose per weight (AUC0-∞/DW) than those with the G/G genotype (p = 0.012) and lower volume of distribution (Vd/F) and clearance (Cl/F) (p = 0.001 and p = 0.012, respectively). Subjects with the ABCC2 rs2273697 A/A genotype presented lower tmax (i.e., the time to reach the maximum concentration, Cmax) compared to those with G/G+G/A genotypes (p = 0.001). Volunteers with the SLC22A1 *1/*5 genotype exhibited lower Cmax/DW and higher tmax (p = 0.003 and p = 0.018, respectively) than subjects with the *1/*1 diplotype. Only one adverse drug reaction was reported: headache. Our results suggest the genetic polymorphism of drug transporters, rather than metabolizing enzymes, conditions the pharmacokinetics of rasagiline.
Green Synthesis of Hexagonal Silver Nanoparticles Using a Novel Microalgae Coelastrella aeroterrestrica Strain BA_Chlo4 and Resulting Anticancer, Antibacterial, and Antioxidant Activities
Authors: Hamida Reham Samir , Ali Mohamed Abdelaal , Almohawes Zakiah Nasser , Alahdal Hadil , Momenah Maha Abdullah , Bin-Meferij Mashael Mohammed
Published: September 2022

Microalgae-mediated synthesis of nanoparticles (NPs) is an emerging nanobiotechnology that utilizes the biomolecular corona of microalgae as reducing and capping agents for NP fabrication. This study screened a novel microalgal strain for its potential to synthesize silver (Ag)-NPs and then assayed the biological activities of the NPs. Coelastrella aeroterrestrica strain BA_Chlo4 was isolated, purified, and morphologically and molecularly identified. Chemical composition of the algal extract was determined by GC-MS analysis. Ag-NPs were biosynthesized by C. aeroterrestrica BA_Chlo4 (C@Ag-NPs) and characterized using various techniques. Antiproliferative activity and the biocidal effect of C@Ag-NPs, C. aeroterrestrica algal extract, and chemically synthesized Ag-NPs (Ch@Ag-NPs) were explored, and the scavenging activity of C@Ag-NPs against free radicals was investigated. C@Ag-NPs were hexagonal, with a nanosize diameter of 14.5 ± 0.5 nm and a maximum wavelength at 404.5 nm. FTIR and GC-MS analysis demonstrated that proteins and polysaccharide acted as capping and reducing agents for C@Ag-NPs. X-ray diffraction, energy diffraction X-ray, and mapping confirmed the crystallinity and natural structure of C@Ag-NPs. The hydrodynamic diameter and charge of C@Ag-NPs was 28.5 nm and −33 mV, respectively. C@Ag-NPs showed significant anticancer activity towards malignant cells, with low toxicity against non-cancerous cells. In addition, C@Ag-NPs exhibited greater antioxidant activity and inhibitory effects against Gram-positive and -negative bacteria compared with the other tested treatments. These findings demonstrate, for first time, the potential of a novel strain of C. aeroterrestrica to synthesize Ag-NPs and the potent antioxidant, anticancer, and biocidal activities of these NPs.
Development and Implementation of a Healthcare Database Analysis Course for Graduate Students
Authors: Axon David R.
Published: September 2022

There emerged a need to develop and implement a new healthcare database analysis course for Health Economics and Outcomes Research (HEOR) graduate students, which would allow students to apply their biostatistics and study design skills to answer healthcare-related research questions using large datasets. This communication establishes the need for this course, describes how the course was conceptualized, provides an overview of the course content, course cohort, and course outcomes, and discusses lessons learned from this process. This course was developed to meet the need of HEOR graduates to perform real-world data studies. The course required students to conceptualize a study, apply their data analysis skills to analyze the data, and develop their scientific writing skills by preparing a conference abstract and research report that should be submitted for publication. Lessons learned include focusing more on developing advanced research methodologies and less time on preparing dissemination materials, which can instead be done in subsequent courses or for independent study credit.
Kerr-Nonlinearity-Triggered Nonclassicality of Magnons in a Photon-Magnon Coupling System
Authors: Jiang Xi , Tang Shiqing , Li Songsong
Published: September 2022

Hybrid quantum systems have attracted much attention due to the fact that they combine the advantages of different physical subsystems. Cavity QED (cavity quantum electrodynamics) with magnons is a hybrid quantum systems that combines a YIG (Yttrium Iron Garnet) sphere and a 3D (three-dimensional) rectangular microwave cavity. Based on this hybrid photon-magnon system, we obtain an approximate analytic solution by the RWA (rotating wave approximation) with an ingenious transformation. After skillfully diagonalizing the Hamiltonian, we show that the Kerr-nonlinearity interactions could yield a negativity value of the Wigner function, periodic quadrature squeezing effects, antibunching property, and field nonclassicality in the magnon. Our work may stimulate the study of nonclassicality of photon-magnon coupling systems and its potential applications in quantum information processing.
Identification of the OsCML4 Gene in Rice Related to Salt Stress Using QTL Analysis
Authors: Asif Saleem , Kim Eun-Gyeong , Jang Yoon-Hee , Jan Rahmatullah , Kim Nari , Asaf Sajjad , Lubna  , Farooq Muhammad , Kim Kyung-Min
Published: September 2022

Soil salinity is a major abiotic stress that causes disastrous losses in crop yields. To identify favorable alleles that enhance the salinity resistance of rice (Oryza sativa L.) crops, a set of 120 Cheongcheong Nagdong double haploid (CNDH) lines derived from a cross between the Indica variety Cheongcheong and the Japonica variety Nagdong were used. A total of 23 QTLs for 8 different traits related to salinity resistance on chromosomes 1–3 and 5–12 were identified at the seedling stage. A QTL related to the salt injury score (SIS), qSIS-3b, had an LOD score of six within the interval RM3525–RM15904 on chromosome 3, and a phenotypic variation of 31% was further examined for the candidate genes. Among all the CNDH populations, five resistant lines (CNDH 27, CNDH 34-1, CNDH 64, CNDH 78, and CNDH 112), five susceptible lines (CNDH 52-1, CNDH 67, CNDH 69, CNDH 109, and CNDH 110), and the parent lines Cheongcheong and Nagdong were selected for relative gene expression analysis. Among all the genes, two candidate genes were highly upregulated in resistant lines, including the auxin-responsive protein IAA13 (Os03g0742900) and the calmodulin-like protein 4 (Os03g0743500-1). The calmodulin-like protein 4 (Os03g0743500-1) showed a higher expression in all the resistant lines than in the susceptible lines and a high similarity with other species in sequence alignment and phylogenetic tree, and it also showed a protein–protein interaction with other important proteins. The genes identified in our study will provide new genetic resources for improving salt resistance in rice using molecular breeding strategies in the future.
Identification of Key Genes Related to Dormancy Control in Prunus Species by Meta-Analysis of RNAseq Data
Authors: Calle Alejandro , Saski Christopher , Wünsch Ana , Grimplet Jérôme , Gasic Ksenija
Published: September 2022

Bud dormancy is a genotype-dependent mechanism observed in Prunus species in which bud growth is inhibited, and the accumulation of a specific amount of chilling (endodormancy) and heat (ecodormancy) is necessary to resume growth and reach flowering. We analyzed publicly available transcriptome data from fifteen cultivars of four Prunus species (almond, apricot, peach, and sweet cherry) sampled at endo- and ecodormancy points to identify conserved genes and pathways associated with dormancy control in the genus. A total of 13,018 genes were differentially expressed during dormancy transitions, of which 139 and 223 were of interest because their expression profiles correlated with endo- and ecodormancy, respectively, in at least one cultivar of each species. The endodormancy-related genes comprised transcripts mainly overexpressed during chilling accumulation and were associated with abiotic stresses, cell wall modifications, and hormone regulation. The ecodormancy-related genes, upregulated after chilling fulfillment, were primarily involved in the genetic control of carbohydrate regulation, hormone biosynthesis, and pollen development. Additionally, the integrated co-expression network of differentially expressed genes in the four species showed clusters of co-expressed genes correlated to dormancy stages and genes of breeding interest overlapping with quantitative trait loci for bloom time and chilling and heat requirements.
Structural Testing by Torsion of Scalable Wind Turbine Blades
Authors: Morăraș Ciprian Ionuț , Goanță Viorel , Istrate Bogdan , Munteanu Corneliu , Dobrescu Gabriel Silviu
Published: September 2022

In life service, the wind turbine blades are subjected to compound loading: torsion, bending, and traction, all these resulting in the occurrence of normal and tangential stresses. At some points, the equivalent stresses, due to overlapping effects provided by normal and shear stresses, can have high values, close to those for which the structure can reach to the failure point. If the effects of erosion and clashes with foreign bodies are added, the structure of the blade may lose its integrity. Considering both the complex shape of the blade and internal structure used, the mechanical behavior of the blade, such as the rigidity and resistance along the length of the blade, are usually determined with some uncertainty. This paper presents the results obtained in the non-destructive tests at static torsion of a scalable wind turbine blade. The objective of the paper was to determine the variation of the equivalent stress in the most stressed points of the blade, in relation to the torques applied. To determine the points with the highest stress, a finite element analysis was performed on the scalable wind turbine blade. Electrotensiometric transducers were mounted at different points of the blade, determining the main stresses in the respective points, as well as their variation during the torsion test, by subsequent calculations. The determinations were performed by applying the torque in both senses, in relation to the blade axis, thus concluding the values of the equivalent stress in the two cases.
Smart Self-Nourishing and Self-Healing Artificial Skin Composite Using Bionic Microvascular Containing Liquid Agent
Authors: Gao Xu , Su Jun-Feng , Wang Sai , Yang Peng
Published: September 2022

Artificial skin composites have attracted great interest in functional composite materials. The aim of this study was to prepare and characterize a smart artificial skin composite comprising a bionic microvascular with both self-nourishing and self-healing functions. A poly(vinyl alcohol)–glycerol–gelatin double network organic hydrogel was used as the artificial skin matrix. The hydrogel had high mechanical strength because of the strong hydrogen bond formed between the PVA and glycerol (GL). The gelatin (GEL) increased the toughness and elasticity of the hydrogel to ensure the strength of the artificial skin and fit of the interface with the body. The bionic polyvinylidene fluoride (PVDF) microvascular had excellent thermal stability and mechanical property in artificial skin. Results indicated that self-nourishing was successfully realized by liquid release through the pore structures of the bionic microvascular. The bionic microvascular healed microcracks in the artificial skin when damage occurred, based on a self-healing test.
Structural Health Monitoring Impact Classification Method Based on Bayesian Neural Network
Authors: Yu Haofan , Seno Aldyandra Hami , Sharif Khodaei Zahra , Aliabadi M. H. Ferri
Published: September 2022

This paper proposes a novel method for multi-class classification and uncertainty quantification of impact events on a flat composite plate with a structural health monitoring (SHM) system by using a Bayesian neural network (BNN). Most of the existing research in passive sensing has focused on deterministic approaches for impact detection and characterization. However, there are variability in impact location, angle and energy in real operational conditions which results in uncertainty in the diagnosis. Therefore, this paper proposes a reliability-based impact characterization method based on BNN for the first time. Impact data are acquired by a passive sensing system of piezoelectric (PZT) sensors. Features extracted from the sensor signals, such as their transferred energy, frequency at maximum amplitude and time interval of the largest peak, are used to develop a BNN for impact classification (i.e., energy level). To test the robustness and reliability of the proposed model to impact variability, it is trained with perpendicular impacts and tested by variable angle impacts. The same dataset is further applied in a method called multi-artificial neural network (multi-ANN) to compare its ability in uncertainty quantification and its computational efficiency against the BNN for validation of the developed meta-model. It is demonstrated that both the BNN and multi-ANN can measure the uncertainty and confidence of the diagnosis from the prediction results. Both have very high performance in classifying impact energies when the networks are trained and tested with perpendicular impacts of different energy and location, with 94% and 98% reliable predictions for BNN and multi-ANN, respectively. However, both metamodels struggled to detect new impact scenarios (angled impacts) when the data set was not used in the development stage and only used for testing. Including additional features improved the performance of the networks in regularization; however, not to the acceptable accuracy. The BNN significantly outperforms the multi-ANN in computational time and resources. For perpendicular impacts, both methods can reach a reliable accuracy, while for angled impacts, the accuracy decreases but the uncertainty provides additional information that can be further used to improve the classification.
Self-Healable Covalently Adaptable Networks Based on Disulfide Exchange
Authors: Guo Xinru , Liu Feng , Lv Meng , Chen Fengbiao , Gao Fei , Xiong Zhenhua , Chen Xuejiao , Shen Liang , Lin Faman , Gao Xuelang
Published: September 2022

Introducing dynamic covalent bonding into thermoset polymers has received considerable attention because they can repair or recover when damaged, thereby minimizing waste and extending the service life of thermoset polymers. However, most of the yielded dynamic covalent bonds require an extra catalyst, high temperature and high-pressure conditions to trigger their self-healing properties. Herein, we report on a catalyst-free bis-dynamic covalent polymer network containing vinylogous urethane and disulfide bonds. It is revealed that the introduction of disulfide bonds significantly reduces the activation energy (reduced from 94 kJ/mol to 51 kJ/mol) of the polymer system for exchanging and promotes the self-healing efficiency (with a high efficiency of 86.92% after being heated at 100 °C for 20 h) of the material. More importantly, the mechanical properties of the healed materials are comparable to those of the initial ones due to the special bis-dynamic covalent polymer network. These results suggest that the bis-dynamic covalent polymer network made of disulfide and inter-vinyl ester bonds opens a new strategy for developing high-performance vitrimer polymers.
Microfluidics-Assisted Fabrication of Dual Stopband Photonic Microcapsules and Their Applications for Anticounterfeiting
Authors: Zhou Can , Zhang Shoubin , Hui Taoran , Cui Qiuhong , Hu Yuandu
Published: September 2022

The assembly of two different kinds of colloidal particle-based photonic structures into an individual micro-object can achieve multifunctionality. In this study, core–shell photonic microcapsules with dual structural colors and photonic stop bands were prepared through a standard microfluidic technique. Photocurable resin suspension of silica nanoparticles and an aqueous suspension of nanogels were used as shell and core parts of microcapsules, respectively. The structural colors of shells and cores can be tuned by adjusting the concentrations of silica nanoparticles and soft nanogels in their corresponding suspensions. The individual microcapsules possess two distinct stop bands when the two suspensions are combined appropriately. Remarkably, the color information of the core part cannot be directly viewed at a macroscopic level (such as visual inspection) but can be detected at a microscopic scale (such as optical microscopy observation). The color information hidden enables the capability for information encryption and has potentially critical applications in anti-counterfeiting, display, and other fields.
Modern ecological and hygienic problems of fish products safety, associated with the development of pond fish farming in the Saratov region
Authors:   Federal State Budgetary Educational Institution of Higher Education «Saratov State Medical University named after V. I. Razumovsky » of Ministry of Health of the Russian Federation, Saratov, Russia, Eliseev Yu. Yu. , Vojtovich A. A. ,   Federal State Budgetary Educational Institution of Higher Education «Saratov State Medical University named after V. I. Razumovsky » of Ministry of Health of the Russian Federation, Saratov, Russia, Eliseeva Yu. V. ,   Federal State Budgetary Educational Institution of Higher Education «Saratov State Medical University named after V. I. Razumovsky » of Ministry of Health of the Russian Federation, Saratov, Russia, Pichygina N. N. ,   Federal State Budgetary Educational Institution of Higher Education «Saratov State Medical University named after V. I. Razumovsky » of Ministry of Health of the Russian Federation, Saratov, Russia, Elissev D. Yu. ,   Federal State Budgetary Educational Institution of Higher Education «Saratov State Medical University named after V. I. Razumovsky » of Ministry of Health of the Russian Federation, Saratov, Russia, Sergeeva E. S. ,   Federal State Budgetary Educational Institution of Higher Education «Saratov State Medical University named after V. I. Razumovsky » of Ministry of Health of the Russian Federation, Saratov, Russia
Published: September 2022

Materials about the study of the content of heavy metals and organochlorine pesticides in carp fishes of the agricultural sector, which is successfully developed in the Saratov region — pound fish farming, are presents in this article. It was found that the territorial location of pond production influence on the content of heavy metals and pesticides in fish. The content of the metals lead, cadmium and mercury in the liver and gonads of carp was higher than the permissible values when growing fish in ponds located in the city near highways. On the contrary, pesticides were detected in fish organs only in the territories of pond fish farming of agricultural farms. At the same time, the residual concentrations of organochlorine pesticides contained in freshwater fish did not exceed the maximum permissible levels. In order to safely consume fish grown near highways of the city limits, which are sources of heavy metal emissions, it should be recommended to remove internal organs (liver and gonads) from fish products.
Children’s rest and recovery in the context of a shorter shift during the COVID-19 pandemic
Authors:   Federal State Budgetary Educational Institution of Higher Education Astrakhan Medical State University Russian Federation Ministry of Health, Astrakhan, Russia, Antonova A. A. , Yamanova G. A. ,   Federal State Budgetary Educational Institution of Higher Education Astrakhan Medical State University Russian Federation Ministry of Health, Astrakhan, Russia
Published: September 2022

The coronavirus pandemic has made significant changes in our lives. The organization of summer health-improving recreation takes one of the leading places in the problem of preserving and strengthening the health of children. Summer is one of the natural environmental factors that increase the internal reserves of the body and contributes to the development of the child’s physical abilities. One of the important health-preserving factors is the duration of the shift during which the health of children takes place. The article is devoted to assessing the effectiveness of the summer health campaign in the Astrakhan region in the context of a shortened 14‑day shift. On the basis of the children’s health center «named after A. S. Pushkin» conducted research, which was attended by children aged 7–15 years during the summer health campaign. The data obtained were analyzed using generally accepted methods of mathematical statistics. To identify the level of significance of differences we used Student’s t-test. The health-improving effect was analyzed and a conclusion was made about the short time spent by children in order to obtain a positive dynamic of indicators of physical fitness. The effectiveness of the health improvement of the rested in 2021 was as follows: a pronounced health-improving effect was observed in 51.9 % of children. A weak health-improving effect was noted in — 32.2 %, the absence of a health-improving effect — in 15.9 % of children. The results obtained during the study will make it possible to determine the directions and forms of organization of medical care in order to prevent deviations in the state of health. These results can serve as a basis for further development of control measures and means of promoting and maintaining the health of children in the context of the COVID-19 pandemic. Thus, shifts lasting at least 21 days can be considered wellness.
Features of accounting for transportation and procurement costs when purchasing stocks
Authors:   Federal State Budgetary Educational Institution of Higher Education «Russian State Agrarian University — Moscow Agricultural Academy named after K. A. Timiryazev», Moscow, Russia, Postnikova L. V. , Shadrina M. A. ,   Federal State Budgetary Educational Institution of Higher Education «Russian State Agrarian University — Moscow Agricultural Academy named after K. A. Timiryazev», Moscow, Russia, Kharcheva I. V. ,   Federal State Budgetary Educational Institution of Higher Education «Russian State Agrarian University — Moscow Agricultural Academy named after K. A. Timiryazev», Moscow, Russia
Published: September 2022

The authors considered the requirements of the FSB 5/2019 «Reserves» in terms of accounting organizations in the formation of the actual cost of purchased stocks. Special attention is paid to the concept and composition of transport and procurement costs, within their approximate nomenclature. The options for reflecting these expenses in accounting with the help of accounts 15 «Procurement and acquisition of tangible assets», 16 «Deviation in the value of tangible assets» and 10 «Materials», forms of primary documents used, examples of their reflection in the accounting of the organization are given, the requirements of tax accounting are considered.
Los factores jurídicos determinantes en el rescate humanitario de ciudadanos ecuatorianos dentro del conflicto Ucrania-Rusia
Authors: Veloz Sanchez Paula Alexandra , Durán Chérrez Paúl Cafú
Published: September 2022

Ecuador se posiciona como el país con más ciudadanos en Ucrania que cualquier otro de Latinoamérica; por lo tanto, la importancia de conocer cómo ocurrió el retorno de estos, dentro del conflicto bélico, a través del derecho, es sumamente importante. Como objetivo de esta investigación, se analizó los factores jurídicos determinantes para que se pueda dar un rescate humanitario a ciudadanos ecuatorianos que se encontraron dentro de la zona de conflicto en la guerra entre Ucrania y Rusia. Se aplicó la metodología cualitativa en base a un enfoque exploratorio descriptivo, dado que se analizaron documentos y normativa nacional e internacional para poder llegar a la conclusión que, a través de Derecho Internacional y de normativa ecuatoriana, se pudo dar el rescate humanitario de ciudadanos ecuatorianos.
La problemática social y ecológica en la microcuenca del Cupatitzio-Márquez
Authors: Sánchez Andrade Diana Elizabeth , Sandoval Contreras Rigoberto
Published: September 2022

En este trabajo se resumen los resultados de una investigación realizada sobre la problemática de la microcuenca del Cupatitzio-Marqués ubicada en el estado de Michoacán.  El tema trata de cómo a partir del uso intensivo y diversificadoque se le ha dado al agua del río Cupatitzio-Marqués, desde mediados del siglo XIX y hasta em momento actual, hacontribuido a la transformación de los paisajes, al deterioro medioambiental y al proceso de formación de relaciones depoder de los diferentes grupos socioculturales presentes en las tres zonas bioclimáticas de una unidad ecológica vertebrada poresta corriente de agua.
In memoriam. Mercedes Olivera Bustamante, mujer indómita…
Authors: Salazar Peralta Ana María
Published: September 2022

A Mercedes Olivera podemos definirla como una mujer luminosa, feminista y revolucionaria en todo sentido de la palabra, siempre coherente con sus convicciones marxistas. Luchó desde adentro de las instituciones por los derechos humanos, por la dignidad de las personas refugiadas centroamericanas, fundando la organización de Mamá Maquín.
ANALISIS KINERJA WAKTU DAN BIAYA PROYEK KONSTRUKSI DENGAN METODE EARNED VALUE ANALYSIS
Authors: Marini Indriani Andi , Utomo Gunaedy , Rizqy Muhammad
Published: September 2022

The International Airport Sultan Aji Muhammad Sulaiman (SAMS), Sepinggan Balikpapan is the gateway to East Kalimantan and is an airport with high aircraft movements every year. Periodic maintenance must be carried out to support airport performance. Runway surface overlay and paved shoulders is one of the works carried out for this purpose. In a construction project, good management is needed to control so that the project runs according to the planned time and cost. Earned Value Analysis (EVA) is one method that can be used to control projects. After analyzing using project data from week 1 to week 47, it is known that the costs incurred are greater than the budgeted value, this is indicated by the CPI value = 0.998. The implementation time is faster than the planned schedule, as seen in the SPI value of 1.142. The result of the final calculation of the project which indicates a loss and an estimated turnaround time of 65 weeks indicates a 4 week acceleration.
Alternative Exploration in the Denison Trough
Authors: Crowley James ,   State Gas Ltd
Published: September 2022

State Gas was formed in 2017 to develop an historic shallow gas resource at PL-231 Reid’s Dome in the Denison Trough. The company used simultaneous inversion to define the extent of the gas and identify further exploration targets. Between 2018 – 2020, State Gas tested the coal-seam gas potential of the Reid’s Dome Beds in PL-231 and subsequently tested the Bandanna Coal measures in the newly awarded ATP-2062. In September 2021, State Gas entered into a Memorandum of Understanding with Rockminsolutions Pty Ltd to evaluate the Buckland Tableland Volcanics within EPM-27596 which partially overlies ATP-2062. The permits contain a significant area with potential for carbon mineralisation using the "CarbFix" process which can permanently store CO2 removed from produced gas or from the atmosphere.
Conceptual Framework for Hydrologic Modelling of Faults
Authors: Murray Titus ,   Southern Highlands Structural Geology, Power William L.
Published: September 2022

Unconventional oil and gas developments may require considering the potential hydrological impacts of faults on near-surface groundwater assets. It is vital that faults are represented appropriately. There are several examples where faults have been invoked as part of “Straw Man” arguments to oppose development (Currell et. al. 2017 and Iverach et. al. 2020). The processes of dewatering and hydraulic fracture stimulation may generate preferential pathways for flow that impact aquifers and groundwater dependant ecosystems. As part of this, a clear framework for the assessment of the impact of faults has been provided in Murray and Power 2021. This study presents three distinct end-member geological scenarios and outlines methods for characterising faultrelated groundwater flow within a risk assessment context. 1) Regional aquitard isolates aquifer from development. Low risk of leakage across the aquitard because there are no faults, or the faults have displacements less than the thickness of the aquitard. 2) Region-wide aquitard is not present, the development and the groundwater assets are within the same groundwater system. CSG development may cause pressure to propagate parallel to the strike and dip of the fault in the fault damage zones. 3) Regional aquitard(s) are present, but larger displacement faults breach the aquitards, allowing for possible combinations of across-fault connections between the different aquifers, and between aquifers and the coal seams. In this scenario, potential flow pathways between the groundwater and the development need to be characterised using Allan Maps (fault plane profiles).
Natural hydrogen exploration in South Australia
Authors: Alexander Elinor ,   Department for Energy & Mining, South Australia
Published: September 2022

South Australia has taken the lead nationally in enabling exploration licences for natural hydrogen. On 11 February 2021 the Petroleum and Geothermal Energy Regulations 2013 were amended to declare hydrogen, hydrogen compounds and by-products from hydrogen production regulated substances under the Petroleum and Geothermal Energy Act 2000 (PGE Act). Companies are now able to apply to explore for natural hydrogen via a Petroleum Exploration Licence (PEL) and the transmission of hydrogen or compounds of hydrogen are now permissible under the transmission pipeline licencing provisions of the PGE Act. The maximum area of a PEL is 10,000 square kilometres so they provide a large acreage position for explorers. PEL applicants need to provide evidence of their technical and financial capacity as well as a 5-year work program which could include field sampling, geophysical surveys (e.g., aeromagnetics, gravity, seismic and MT) and exploration drilling to evaluate the prospectivity of the licence for natural hydrogen. Since February 2021, seven companies have lodged 35 applications for petroleum exploration licences (PELs), targeting natural hydrogen. The first of these licences (PEL 687) over Kangaroo Island and southern Yorke Peninsula was granted to Gold Hydrogen Pty Ltd on 22 July 2021. As well as issuing exploration licences, a key role of the South Australian Department for Energy and Mining is to provide easy access to comprehensive geoscientific data submitted by mineral and petroleum explorers and departmental geoscientists since the State was founded in 1836. Access to old 1920s and 1930s reports, together with modern geophysical and well data has underpinned the current interest in hydrogen exploration. Why the interest? 50-80% hydrogen content was measured in 1931 by the Mines Department in gas samples from wells on Kangaroo Island, Yorke Peninsula and the Otway Basin, potential evidence that the natural formation of hydrogen has occurred. Iron-rich cratons and uranium-rich basement (also a target for geothermal energy explorers) occur in the Archaean-Mesoproterozoic Gawler Craton, Curnamona and Musgrave provinces which are in places fractured and seismically active with deep-seated faults. Sedimentary cover ranges from Neoproterozoic-Recent in age, with thick clastic, carbonate and coal measure successions in hydrocarbon prospective basins and, in places, occurrences of mafic intrusives and extrusives, iron stones, salt and anhydrite which could also be potential sources of natural hydrogen.
Estimating methane flux rates from drone concentration measurements
Authors: Gargiulo Grazia ,   UQ Centre for Natural Gas, Hoerning Sebastian
Published: September 2022

In its Climate Transition Strategy, the Queensland Government has set a zero net emission target by 2050, with an interim target for at least a 30% reduction in emissions on 2005 levels by 2030. QLD’s total fugitive emissions however have increased by 79% from 2005 to 2016, mainly due to the expansion in the state’s coal and gas extractive industries. Fugitive emissions are inherently difficult to quantify since they are often scattered over large areas. Drones specialised in the detection and measurements of methane concentrations can be used to identify point source of fugitive emissions. However, concentrations are just a snapshot in space/time and to be able to quantify the actual emissions, the underlying methane flux (i.e., the amount of methane per time unit over a specific area) is required. In this talk, we are going to present details on the data acquisition for fugitive methane emissions using drones. First attempts at estimating the underlying fluxes will be presented and a controlled methane release experiment, required for calibration and validation purposes, is discussed.
Brazilian Thoracic Association Consensus on Sleep-disordered Breathing
Authors: Luiz de Menezes Duarte1 Ricardo , Maria Guimarães Pereira Togeiro2,3, Sonia , de Oliveira Palombini3 Luciana , Paula Galhardo Rizzatti4 Fabíola , Chaves Fagondes5 Simone , José Magalhães-da-Silveira6a Flavio , Montenegro Cabral7 Marília , Rodrigues Genta8 Pedro , Lorenzi-Filho8 Geraldo , Cristina Silva Clímaco9 Danielle , Ferreira Drager10 Luciano , Martins Codeço11 Vitor , Alberto de Assis Viegas12 Carlos , Fouad Rabahi13 Marcelo
Published: September 2022

Sleep is essential for the proper functioning of all individuals. Sleep-disordered breathing can occur at any age and is a common reason for medical visits. The objective of this consensus is to update knowledge about the main causes of sleep-disordered breathing in adult and pediatric populations, with an emphasis on obstructive sleep apnea. Obstructive sleep apnea is an extremely prevalent but often underdiagnosed disease. It is often accompanied by comorbidities, notably cardiovascular, metabolic, and neurocognitive disorders, which have a significant impact on quality of life and mortality rates. Therefore, to create this consensus, the Sleep-Disordered Breathing Department of the Brazilian Thoracic Association brought together 14 experts with recognized, proven experience in sleep-disordered breathing.
USE OF LATENT-SEMANTIC ANALYSIS IN PREPARATION OF DATA FOR IDENTIFICATION OF ANONYMOUS USERS BY DIGITAL FINGERPRINTS
Authors:   MTUCI, SHELUHIN OLEG I. , VANYUSHINA ANNA V. ,   MTUCI, ZHELNOV MAKSIM S. ,   MTUCI
Published: September 2022

Digital fingerprints changings over time as a result of system, plugins, browsers, installation of various programs updates and fonts is a serious problem in the method of tracking and identifying users using a browser (Fingerprinting (FP) of a web browser). The set of parsed attributes can contain both metrical and categorical (mostly non-numeric) values, for example, parameters such as user-agent, webgl, canvas, etc. Considering this, it is required to pre-encode them for the convenience of further processing. For these purposes, artificial intelligence technologies, including the processing of text in natural languages NLP (Natural Language Processing), are widely used. The aim of the research is to analyze the peculiarities of the implementation of latent-semantic analysis (LSA) in the preparation and analysis of FP data for the identification of anonymous users. Methods. A comparative analysis of the common ways of converting categorical values of fingerprint attributes (FP) into numeric One-Hot-Encoding, Label-Encoder, LSA for identifying anonymous users with a predetermined number of possible values of categorical features is carried out. Results. The advantage of the LSA algorithm over One-Hot-Encoding, Label-Encoder is shown. The possibility of clustering implementation within the framework of the user identification problem by visualizing FP (FP) relative to hidden semantic topics using the LSA model of latent semantic analysis is shown. It is shown that with a small number of hid& den topics using the obtained vectors of objects and vectors of terms for assessing the similarity of two FPs, the proposed model allows us to confidently classify the input FP to a common topic. With the help of the obtained vectors of objects and vectors of terms for assessing the similarity of two FP objects, it becomes possible to apply various measures of cluster proximity: Euclidean distance, cosine measure, etc.
KALMAN FILTER USE ANALYSIS IN SIGNAL DETECTION PROCEDURE IN SYSTEM WITH MIMO AND DIRECT CONVERSION RECEIVER
Authors:   MTUCI, POBORCHAYA NATALYA E. , LOBOVA ELIZAVETA O. ,   MTUCI
Published: September 2022

Introduction: The procedure for detecting a quadrature amplitude modulation (QAM) signal in a communication system with multiple transmitting and receiving antennas (MIMO) is considered, which consists of two stages: obtaining soft solutions using the recurrent Kalman filtering algorithm, finding hard solutions by criterion of minimum distance between soft decision vectors and possible information symbols on each receiving antenna. The Kalman algorithm evaluates symbols at i-th time point in iterations. A comparison is made of noise immunity of QAM signal reception obtained using the Zero Forcing methods, the minimum mean square error (RMS), and recurrent Kalman procedure. Signal processing takes place under channel conditions with Rayleigh fading and Doppler spread spectrum. Cases are considered when the channel matrix is known exactly and when it is estimated by least squares method (LSM) using a first-order polynomial approximation for channel matrix elements. The channel matrix takes into account not only signal distortions due to the propagation medium, but also distortions obtained in the direct conversion receiver, such as amplitude and phase imbalance between signal quadratures, frequency shift due to non-ideal demodulation procedure, as well as DC drift. Result: The computational complexity of the detector based on Kalman algorithm is analyzede.
THE USE OF ADVANCED MULTIFUNCTIONAL ECHELONED AERIAL COMPLEX BASED ON LIGHTER THAN AIR AIRCRAFTS IN THE WORK OF INTERNAL AFFAIRS BODIES
Authors:   St. Petersburg University of the Ministry of Internal Affairs, GRACHEV YURII A. , SOKOLOV VIKTOR M. ,   St. Petersburg University of the Ministry of Internal Affairs, MELNIKOV NICOLAI M. ,   St. Petersburg University of the Ministry of Internal Affairs, LOKTIONOV OLEG V. ,   St. Petersburg University of the Ministry of Internal Affairs
Published: September 2022

Introduction: The paper substantiates a justification for the use of Lighter-Than-Air aircrafts in the interests of the internal affairs bodies of the Russian Federation. Purpose: Аnalysis of existing Heavier-Than-Air unmanned aircrafts and Lighter-Than-Air aircrafts capabilities, as well as review of a wide range of payloads with the aim of synthesis of the multilevel aerial complex destined for the internal affairs bodies. Results: Based on the analysis of existing unmanned aerial vehicles and Lighter-Than-Air aircrafts, the article proposes the composition and further use of multifunctional echeloned air complex based on lighter-than-air aircrafts designed for the internal affairs bodies. Taking into consideration the internal affairs bodies tasks specificity, various options of an air complex construction scheme, as well as its equipment with designed and existing payload modules, are proposed. Practical relevance: Practical recommendations for the construction of a two-tier scheme air complex for internal affairs bodies based on Lighter-Than-Air aircrafts have been developed. The first tier is built on well-known samples of tethered balloon complexes (stationary component) and medium-altitude unmanned airships (mobile component), as well as perspective small (up to 50 kilograms of payload) and ultra-small (up to 20 kilograms of payload) tethered and unmanned aerial vehicles (stationary and mobile components) proposed in this article. The second tier comprises the unmanned high-altitude aerostatic platforms (mobile component). Discussion: the results obtained in the article are proposed to be used for the calculation of the individual modules performance characteristics, of the performance characteristics of a repeater system built on the basis of airships and for developing an algorithm for the coordination control of the interoperable Lighter-Than-Air aircrafts and Heavier-Than-Air unmanned aircrafts.
TWO-STAGE ALGORITHM FOR CONSISTENT SIGNALS FILTERING
Authors:   Sevastopol State University, DEGTYAREV ANDREY N. , KOZHEMYAKIN ALEXANDER S. ,   Sevastopol State University, AFONIN IGOR L. ,   Sevastopol State University, SLEZKIN GENNADY V. ,   Sevastopol State University, POLYAKOV ALEXANDER L. ,   Sevastopol State University
Published: September 2022

Introduction. Introduction. To combat inter-symbol interference resulting from multipath signal propagation, spreading of the signal frequency spectrum, channel equalizing, OFDM-multiplexing with orthogonal frequency division of channels is used. To reduce the influence of non-linear signal distortions, methods of pre-distortion, diversity reception, as well as special algorithms for digital processing of the demodulator output signal are used. The effect of additive noise is reduced by using a filter matched to the signal. Objective. It is advisable to develop a matched filtering algorithm that allows one to simultaneously reduce the influence of additive noise, non-linear signal distortions and its multipath propagation on the correct message reception. The idea of selecting the orthogonality weight can also be used to achieve the goal. Result. To reduce the influence of non-linear distortions on the correct reception of a message under conditions of multipath signal propagation and additive interference, it is proposed to use two stages of signal processing. The first step is to minimize the noise dispersion caused by intersymbol interference and non-linear signal distortions. The specified dispersion is minimized by determining the orthogonality weight of the basis-functions that make up the signal. The second step is to use a classic matched filter. The proposed two-stage matched filtering algorithm makes it possible to simultaneously reduce the influence of non-linear distortions, intersymbol interference resulting from multipath propagation, and additive interference on the correct signal reception. Signals distorted and delayed in time relative to the main signal are proposed to be considered as additive interference.
GNSS RECEIVER SENSITIVITY
Authors:   Moscow Aviation Institute (National Research University), ZHODZISHSKY MARK I. , KURYNIN ROMAN V. ,   National Research University "Higher School of Economics", SERKIN FEDOR B. ,   Moscow Aviation Institute (National Research University),   Topcon positioning systems
Published: September 2022

Introduction. The article is devoted to determining the minimum (threshold) SNRthr values at which GNSS receivers can operate in high-precision phase mode and in less accurate code mode. These minimum (threshold) values of SNRthr are determined primarily by the GNSS receivers' carrier synchronization systems (CCH – carrier synchronization systems) and code delay (CVS – delay tracking schemes). The article considers two types of SSN (PLS and FAP) and two types of SSS – coherent (CSSS) and non-coherent (NSSS) – depending on the sensitivity of the SSS to the carrier phase. Any of these CVDs can be autonomous or guided by target designations from the SSN. Objective. The systems of synchronization of GNSS receivers in phase (frequency) of the carrier (PLL, FAP) and in code delay (CVD) are considered, taking into account their interaction with each other in a high-precision phase mode (with centimeter accuracy) and in a coarser, but more noise-resistant code mode. (with meter accuracy). Satellite signals can be of two types: data – inversely modulated a priori unknown binary symbols (μ=+1), or pilot – without such modulation, as well as with different types of modulation (BPSK, BOC, etc.). Tracking errors and minimum SNR (Signal-to-Noise density Ratio) values are estimated at which these systems (and, consequently, the entire receiver as a whole) can still work normally. Two traditional combinations of synchronization systems by carrier and by code are considered, namely: PLL + coherent CVD; FAP+incoherent CVD; as well as non-traditional FAP + non-coherent CVD. According to the results of the studies, it is the last link (PLL + non-coherent CVD) that is recommended for synchronizing GNSS receivers to ensure their best sensitivity. It is shown that the dynamic properties of FAP and FAP from the point of view of their CVD are equivalent in the linear mode, however, FAP provides much greater dynamic stability than FAP at high SNR.