bluuebunny/crossref_metadata_2025 huggingface dataset:
Educational Needs of Patients Undergoing Total Joint Arthroplasty
Authors: Soever Leslie J. , MacKay Crystal , Saryeddine Tina , Davis Aileen M. , Flannery John F. , Jaglal Susan B. , Levy Charissa , Mahomed Nizar
Published: July 2010

Purpose: To identify the educational needs of adults who undergo total hip and total knee replacement surgery.

Methods: A qualitative research design using a semi-standardized interviewing method was employed. A purposive sampling technique was used to recruit participants, who were eligible if they were scheduled to undergo total hip or total knee replacement or had undergone total hip or total knee replacement in the previous 3 to 6 months. A comparative contrast method of analysis was used.

Results: Of 22 potential participants who were approached, 15 participated. Five were booked for upcoming total hip or total knee replacement and 10 had undergone at least one total hip or total knee replacement in the previous 3 to 6 months. Several themes related to specific educational needs and factors affecting educational needs, including access, preoperative phase, surgery and medical recovery, rehabilitation process and functional recovery, fears, and expectations counterbalanced with responsibility, emerged from the interviews.

Conclusions: Educational needs of adults who undergo total hip and knee replacement surgery encompass a broad range of topics, confirming the importance of offering an all-inclusive information package regarding total hip and total knee replacement.
Physical Therapy Management for Adult Patients Undergoing Cardiac Surgery: A Canadian Practice Survey
Authors: Overend Tom J. , Anderson Cathy M. , Jackson Jennifer , Lucy S. Deborah , Prendergast Monique , Sinclair Susanne
Published: July 2010

Purpose: To determine current Canadian physical therapy practice for adult patients requiring routine care following cardiac surgery.

Methods: A telephone survey was conducted of a selected sample (n=18) of Canadian hospitals performing cardiac surgery to determine cardiorespiratory care, mobility, exercises, and education provided to patients undergoing cardiac surgery.

Results: An average of 21 cardiac surgeries per week (range: 6–42) were performed, with an average length of stay of 6.4 days (range: 4.0–10.6). Patients were seen preoperatively at 7 of 18 sites and on postoperative day 1 (POD-1) at 16 of 18 sites. On POD-1, 16 sites performed deep breathing and coughing, 7 used incentive spirometers, 13 did upper-extremity exercises, and 12 did lower-extremity exercises. Nine sites provided cardiorespiratory treatment on POD-3. On POD-1, patients were dangled at 17 sites and mobilized out of bed at 13. By POD-3, patients ambulated 50–120 m per session 2–5 times per day. Sternal precautions were variable, but the lifting limit was reported as ranging between 5 lb and 10 lb.

Conclusions: Canadian physical therapists reported the provision of cardiorespiratory treatment after POD-1. According to current available evidence, this level of care may be unnecessary for uncomplicated patients following cardiac surgery. In addition, some sites provide cardiorespiratory treatment techniques that are not supported by evidence in the literature. Further research is required.
Discharge from Outpatient Orthopaedic Physiotherapy: A Qualitative Descriptive Study of Physiotherapists' Practices
Authors: Pashley Emilie , Powers Ashley , McNamee Nicole , Buivids Rachel , Piccinin JoAnne , Gibson Barbara E.
Published: July 2010

Purpose: To describe the clinical and contextual factors that influence physiotherapists' discharge decision-making processes in outpatient orthopaedic settings.

Methods: The study used a descriptive qualitative design that included three key-informant interviews and two focus groups (n=7) of orthopaedic physiotherapists (total n=10) working in the Greater Toronto Area. Interviews and focus groups followed a semi-structured interview guide that included questions pertaining to participants' discharge decision-making processes, salient contextual factors, and challenges. Data were coded and analyzed for emerging categories and themes using constant comparison techniques and group analyses.

Results: Participants indicated that a combination of factors and strategies were brought to bear on discharge decision making but that the process changed with clinical experience. Over time, further emphasis was attributed to the patient's role in his or her rehabilitation, and self-management goals were increasingly promoted. Experience affected how therapists conceptualized their roles in discharge decisions and how they negotiated goals with patients.

Conclusions: Discharge decision making is a complex process that requires integrating numerous factors and negotiating with patients. Physiotherapists' decision-making practices evolve with experience and reveal the complexity of implementing models of “client-centred care” in practice. Further research is needed to explore these findings in other settings.
Effect of Anterior Tibiofemoral Glides on Knee Extension during Gait in Patients with Decreased Range of Motion after Anterior Cruciate Ligament Reconstruction
Authors: Hunt Michael A. , Di Ciacca Stephen R. , Jones Ian C. , Padfield Beverley , Birmingham Trevor B.
Published: July 2010

Purpose: The purpose of this preliminary investigation was to evaluate the effect of anterior tibiofemoral glides on maximal knee extension and selected spatiotemporal characteristics during gait in patients with knee extension deficits after anterior cruciate ligament (ACL) reconstruction.

Methods: Twelve patients with knee-extension deficits after recent ACL reconstructions underwent quantitative gait analyses immediately before and after 10 minutes of repeated anterior tibiofemoral glides on the operative limb, and again after a 10-minute seated rest period.

Results: Maximum knee extension during stance phase of the operative limb significantly increased immediately after the treatment (mean increase: 2.0°±4.1°, 95% CI: 0.6°–3.3°). Maximum knee extension decreased after the 10-minute rest period (mean decrease: 0.9°±1.8°, 95% CI: −0.1°–1.8°), although the decrease was not statistically significant. Small increases in operative limb step length, stride length, and gait speed were observed after the rest period compared to baseline values only.

Conclusions: A single session of anterior tibiofemoral glides increases maximal knee extension during the stance phase of gait in patients with knee-extension deficits. Increases in knee extension are small and short-lived, however, suggesting that continued activity is required to maintain the observed improvements.
A Mathematical Model for DNA Damage and Repair
Authors: Crooke Philip S. , Parl Fritz F.
Published: July 2010

In cells, DNA repair has to keep up with DNA damage to maintain the integrity of the genome and prevent mutagenesis and carcinogenesis. While the importance of both DNA damage and repair is clear, the impact of imbalances between both processes has not been studied. In this paper, we created a combined mathematical model for the formation of DNA adducts from oxidative estrogen metabolism followed by base excision repair (BER) of these adducts. The model encompasses a set of differential equations representing the sequence of enzymatic reactions in both damage and repair pathways. By combining both pathways, we can simulate the overall process by starting from a given time‐dependent concentration of 17β‐estradiol (E2) and 2′‐deoxyguanosine, determine the extent of adduct formation and the correction by BER required to preserve the integrity of DNA. The model allows us to examine the effect of phenotypic and genotypic factors such as different concentrations of estrogen and variant enzyme haplotypes on the formation and repair of DNA adducts.
Preparation of DNA Ladder Based on Multiplex PCR Technique
Authors: Wang Tian-Yun , Guo Li , Zhang Jun-he
Published: July 2010

DNA molecular weight standard control, also called DNA marker (ladder), has been widely used in the experiments of molecular biology. In the paper, we report a method by which DNA marker was prepared based on multiple PCR technique. 100–1000 bp DNA fragments were amplified using the primers designed according to the 6631 ~ 7630 position of lambda DNA. Target DNA fragments were amplified using Touchdown PCR combined with hot start PCR, respectively, followed extracted by phenol/chloroform, precipitated with ethanol and mixed thoroughly. The results showed that the 100–1000 bp DNA fragments were successfully obtained in one PCR reaction, the bands of prepared DNA marker were clear, the size was right and could be used as control in the molecular biology experiment. This method could save time and be more inexpensive, rapid, simple when compared with the current DNA Ladder prepared means.
Structural Determinants of Photoreactivity of Triplex Forming Oligonucleotides Conjugated to Psoralens
Authors: Krishnan Rajagopal , Oh Dennis H.
Published: July 2010

Triplex‐forming oligonucleotides (TFOs) with both DNA and 2′‐O‐methyl RNA backbones can direct psoralen photoadducts to specific DNA sequences. However, the functional consequences of these differing structures on psoralen photoreactivity are unknown. We designed TFO sequences with DNA and 2′‐O‐methyl RNA backbones conjugated to psoralen by 2‐carbon linkers and examined their ability to bind and target damage to model DNA duplexes corresponding to sequences within the human HPRT gene. While TFO binding affinity was not dramatically affected by the type of backbone, psoralen photoreactivity was completely abrogated by the 2′‐O‐methyl RNA backbone. Photoreactivity was restored when the psoralen was conjugated to the RNA TFO via a 6‐carbon linker. In contrast to the B‐form DNA of triplexes formed by DNA TFOs, the CD spectra of triplexes formed with 2′‐O‐methyl RNA TFOs exhibited features of A‐form DNA. These results indicate that 2′‐O‐methyl RNA TFOs induce a partial B‐to‐A transition in their target DNA sequences which may impair the photoreactivity of a conjugated psoralen and suggest that optimal design of TFOs to target DNA damage may require a balance between binding ability and drug reactivity.
Emerging Approaches of Transcatheter Valve Repair/Insertion
Authors: Taramasso Maurizio , Cioni Micaela , Giacomini Andrea , Michev Iassen , Godino Cosmo , Montorfano Matteo , Colombo Antonio , Alfieri Ottavio , Maisano Francesco
Published: July 2010

Aortic stenosis (AS) and mitral regurgitation (MR) account for the majority of valvular diseases and their prevalence is increasing according to increased life expectancy. Surgical treatment is the gold standard, although operative risk may be high in some patients due to comorbidities and age. A large part of the patients at high surgical risk who could beneficiate of treatment are not referred to surgery. Therefore, there is a need of alternative and less invasive procedures.
True Lies: The Double Life of the Nucleotide Excision Repair Factors in Transcription and DNA Repair
Authors: Le May Nicolas , Egly Jean-Marc , Coin Frédéric
Published: July 2010

Nucleotide excision repair (NER) is a major DNA repair pathway in eukaryotic cells. NER removes structurally diverse lesions such as pyrimidine dimers, arising upon UV irradiation or bulky chemical adducts, arising upon exposure to carcinogens and some chemotherapeutic drugs. NER defects lead to three genetic disorders that result in predisposition to cancers, accelerated aging, neurological and developmental defects. During NER, more than 30 polypeptides cooperate to recognize, incise, and excise a damaged oligonucleotide from the genomic DNA. Recent papers reveal an additional and unexpected role for the NER factors. In the absence of a genotoxic attack, the promoters of RNA polymerases I‐ and II‐dependent genes recruit XPA, XPC, XPG, and XPF to initiate gene expression. A model that includes the growth arrest and DNA damage 45α protein (Gadd45α) and the NER factors, in order to maintain the promoter of active genes under a hypomethylated state, has been proposed but remains controversial. This paper focuses on the double life of the NER factors in DNA repair and transcription and describes the possible roles of these factors in the RNA synthesis process.
Selective Incision of the α‐N5‐Methyl‐Formamidopyrimidine Anomer by Escherichia coli Endonuclease IV
Authors: Christov Plamen P. , Banerjee Surajit , Stone Michael P. , Rizzo Carmelo J.
Published: July 2010

Formamidopyrimidines (Fapy) lesions result from ring opening of the imidazole portion of purines. Fapy lesions can isomerize from the natural β‐anomeric stereochemistry to the α‐configuration. We have unambiguously demonstrated that the α‐methyl‐Fapy‐dG (MeFapy‐dG) lesion is a substrate for Escherichia coli Endonuclease IV (Endo IV). Treatment of a MeFapy‐dG‐containing 24 mer duplex with Endo IV resulted in 36–40% incision. The catalytic efficiency of the incision was comparable to that of α‐dG in the same duplex sequence. The α‐ and β‐MeFapy‐dG anomers equilibrate to ~21 : 79 ratio over ~3 days. Related studies with a duplex containing the α‐Fapy‐dG lesion derived from aflatoxin B1 epoxide (α‐AFB‐Fapy‐dG) showed only low levels of incision. It is hypothesized that the steric bulk of the aflatoxin moiety interferes with the binding of the substrate to Endo IV and the incision chemistry.
Pre‐Steady‐State Kinetic Analysis of Truncated and Full‐Length Saccharomyces cerevisiae DNA Polymerase Eta
Authors: Brown Jessica A. , Zhang Likui , Sherrer Shanen M. , Taylor John-Stephen , Burgers Peter M. J. , Suo Zucai
Published: July 2010

Understanding polymerase fidelity is an important objective towards ascertaining the overall stability of an organism′s genome. Saccharomyces cerevisiae DNA polymerase η (yPolη), a Y‐family DNA polymerase, is known to efficiently bypass DNA lesions (e.g., pyrimidine dimers) in vivo. Using pre‐steady‐state kinetic methods, we examined both full‐length and a truncated version of yPolη which contains only the polymerase domain. In the absence of yPolη′s C‐terminal residues 514–632, the DNA binding affinity was weakened by 2‐fold and the base substitution fidelity dropped by 3‐fold. Thus, the C‐terminus of yPolη may interact with DNA and slightly alter the conformation of the polymerase domain during catalysis. In general, yPolη discriminated between a correct and incorrect nucleotide more during the incorporation step (50‐fold on average) than the ground‐state binding step (18‐fold on average). Blunt‐end additions of dATP or pyrene nucleotide 5′‐triphosphate revealed the importance of base stacking during the binding of incorrect incoming nucleotides.
Identification of C-Kit-Positive Interstitial Cells in the Dog Lower Urinary Tract and Relationship with Smooth Muscle and Nerves. Hypotheses for a Likely Pacemaker Role.
Authors: Arrighi Silvana , Bosi Giampaolo , Groppetti Debora , Cremonesi Fausto
Published: July 2010

The aim of this work was to give an evidence of the likely presence of interstitial cells in the canine lower urinary tract and to study their possible interactions with the musculature and the intramural innervation. Cryosections of normal canine bladder and urethra were immunofluorescently labelled with c-kit, a transmembrane, tyrosine kinase growth factor receptor, known to be expressed on the interstitial cells of Cajal (ICCs) of the gut. The relationship with antiactin positive smooth muscle cells and PGP9.5-positive intramural innervation was also investigated by confocal microscopy. Anti-c-kit labelling demonstrated a network of elongated and branched c-kit positive cells, which were located in interstitial spaces, oriented in parallel to the smooth muscle bundles that form the bladder muscular layer, irrespective of dog sex. Cells with a similar localization were also PAS- and NADPH-diaphorase-positive. A contact between c-kit immunofluorescent cells and intramural innervation was demonstrated, too. The roles of interstitial cells might include regulation of smooth muscle activity of the bladder detrusor, integrating neuronal signals during urine storage and voiding.
Symmetric group actions on the cohomology of configurations in $ℝ^d$
Authors: d'Antonio Giacomo , Gaiffi Giovanni
Published: July 2010

In this paper we deal with the action of the symmetric group on the cohomology of the configuration space

C_n(d)

of

n

points in

ℝ^d

. This topic has been studied by several authors and it is well-known that for

d

even,

H^*(C_n(d);ℂ)≌ 2 \operatorname{Ind}^{S_n}_{S_2}1

while, for

d

odd,

H^*(C_n(d);ℂ) ≌ ℂS_n

.

On the cohomology algebra

H^*(C_n(d);ℂ)

, there is, in addition to the natural

S_n

-action, an
extended action
of

S_{n_+1}

; this was shown for the case when

d

is even by Mathieu, Robinson and Whitehouse and the second author using three different methods. For the case when

d

is odd, it was shown by Mathieu (anyway we will give an elementary algebraic construction of the extended action for this case). The purpose of this article is to present some results that can be obtained, in an elementary way, exploiting the interplay between the extended action and the standard action. Among these we will recall a quick proof for the formula cited above for the case when

d

is even and show how to extend this proof to the case when

d

is odd. We will also show how to locate among the homogeneous components of the graded algebra

H^*(C_n(d);ℂ)

the copies of the standard, sign and standard tensor sign representations and we will give explicit formulas for both the extended and the canonical actions on the low-degree cohomology modules.
A Note on Maurin’s Theorem
Authors: Bombieri Enrico , Habegger Philipp , Masser David , Zannier Umberto
Published: July 2010

We combine the strategy described in a paper of the first, third and fourth authors with a recent result of the second author to obtain a new proof of Maurin’s Theorem to the effect that the points satisfying two independent multiplicative relations on a fixed algebraic curve form a finite set when there is no natural obstacle.
Holomorphic mappings associated to composition ideals of polynomials
Authors: Aron Richard M. , Botelho Geraldo , Pellegrino Daniel , Rueda Pilar
Published: July 2010

Many operator ideals

\mathscr I

can be naturally associated to polynomial ideals

\mathscr Q

. In this paper we initiate a research program whose aim is to relate those holomorphic mappings

f

that admit factorizations

f = u\circ g

, where

u\in \mathscr I

and

g

is holomorphic, with those

f

whose derivative belongs to the associated composition polynomial ideal

\mathscr Q =\mathscr I \circ \mathscr P

.
Peano on derivative of measures: strict derivative of distributive set functions
Authors: Greco Gabriele H. , Mazzucchi Sonia , Pagani Enrico M.
Published: July 2010

By retracing research on
coexistent magnitudes
(
grandeurs coexistantes
) by Cauchy [9, (1841)], Peano in
Applicazioni geometriche del calcolo infinitesimale
[48, (1887)] defines the "density" (strict derivative) of a "mass" (a distributive set function) with respect to a "volume" (a positive distributive set function), proves its continuity (whenever the strict derivative exists) and shows the validity of the
mass-density paradigm
: "mass" is recovered from "density" by integration with respect to "volume". It is remarkable that Peano’s strict derivative provides a consistent mathematical ground to the concept of "infinitesimal ratio" between two magnitudes, successfully used since Kepler. In this way the classical (i.e., pre-Lebesgue) measure theory reaches a complete and definitive form in Peano’s
Applicazioni geometriche
. A primary aim of the present paper is a detailed exposition of Peano’s work of 1887 leading to the concept of strict derivative of distributive set functions and their use. Moreover, we compare Peano’s work and Lebesgue’s
La mesure des grandeurs
[35, (1935)]: in this memoir Lebesgue, motivated by coexistent magnitudes of Cauchy, introduces a uniform-derivative of certain additive set functions, a concept that coincides with Peano’s strict derivative. Intriguing questions are whether Lebesgue was aware of the contributions of Peano and which role is played by the notions of strict derivative or of uniform-derivative in today mathematical practice.
Equilibrium configurations of epitaxially strained thin films
Authors: Fusco Nicola
Published: July 2010

We present some regularity results on equilibrium configurations for a variational model introduced to describe the epitaxial growth of an elastic film over a thick flat substrate when a lattice mismatch between the two materials is present. We also give a sufficient condition for local minimality based on second variation and apply it to determine analitycally the critical threshold for the local minimality of the flat configuration.
ChemInform Abstract: On Phase Equilibria and Crystal Structures in the Systems Ce—Pd—B and Yb—Pd—B. Physical Properties of R2Pd13.6B5 (R: Yb, Lu).
Authors: Sologub Oksana , Rogl Peter , Salamakha Leonid , Bauer Ernst , Hilscher Gerfried , Michor Herwig , Gieser Gerald
Published: July 2010

The 850 °C isothermal sections of the title systems are characterized by powder and single crystal XRD.
ChemInform Abstract: Li3V(MoO4)3: A New Material for Both Li Extraction and Insertion.
Authors: Mikhailova D. , Sarapulova A. , Voss A. , Thomas A. , Oswald S. , Gruner W. , Trots D. M. , Bramnik N. N. , Ehrenberg H.
Published: July 2010

The title compound is prepared from stoichiometric mixtures of Li2MoO4, MoO3, and V2O3 (Ar, silica tube, 813 K, 30 h) and characterized by single crystal XRD, electrochemical measurements, XPS, and magnetic measurements.
ChemInform Abstract: Polar Hexagonal Tungsten Oxide (HTO) Materials: (1) Synthesis, Characterization, Functional Properties, and Structure—Property Relationships in A2(MoO3)3(SeO3) (A: Rb+ and Tl+) and (2) Classification, Structural Distortions, and Second‐Harmonic Generating Properties of Known Polar HTOs.
Authors: Chang Hong Youn , Kim Sun Woo , Halasyamani P. Shiv
Published: July 2010

Crystals of the title compounds are prepared from mixtures of MoO3, A2CO3 (A: Rb, Tl), SeO2, and H2O (autoclave, 230 °C, 3 d, 50% and 80% yields for the Rb and Tl compounds, respectively).
ChemInform Abstract: Polarity and Chirality in Uranyl Borates: Insights into Understanding the Vitrification of Nuclear Waste and the Development of Nonlinear Optical Materials.
Authors: Wang Shuao , Alekseev Evgeny V. , Ling Jie , Liu Guokui , Depmeier Wulf , Albrecht‐Schmitt Thomas E.
Published: July 2010

The compounds (IV—VII) and (IX—XII) are synthesized with various Na(Tl):U:B molar ratios using H3BO3 as a reactive flux, and their structures are determined by single crystal XRD.
ChemInform Abstract: Synthesis and Structural Studies of the Transition‐Metal‐Doped Rh Perovskites LaMn0.5Rh0.5O3 and LaCu0.5Rh0.5O3.
Authors: Ting Jimmy , Kennedy Brendan J. , Zhang Zhaoming , Avdeev Maxim , Johannessen Bernt , Jang Ling‐Yun
Published: July 2010

The title compounds are synthesized by solid state reaction of stoichiometric mixtures of La2O3, Rh, and Mn2O3 or CuO (1300 °C, 6 d) and characterized by XANES and powder synchrotron X‐ray and neutron diffraction.
ChemInform Abstract: Catalytic Asymmetric Conjugate Addition of α‐Cyanoketones for the Construction of a Quaternary Stereogenic Center.
Authors: Kawato Yuji , Takahashi Noriko , Kumagai Naoya , Shibasaki Masakatsu
Published: July 2010

The addition of (hetero‐)aryl vinyl ketones to the cyclic cyanoketones provides 1,5‐dicarbonyl compounds with good to excellent yields and enantioselectivities with exception of alkyl vinyl ketone (IIa).
ChemInform Abstract: Copper(I)‐Catalyzed Substitution Reactions of Propargylic Amines: Importance of C(sp)—C(sp3) Bond Cleavage in Generation of Iminium Intermediates.
Authors: Sugiishi Tsuyuka , Kimura Akifumi , Nakamura Hiroyuki
Published: July 2010

Substitution reactions of propargylic amines using various secondary amines proceed in the presence of a copper(I) catalyst.
ChemInform Abstract: Conjugated Diene‐Assisted Allylic C—H Bond Activation: Cationic Rh(I)‐Catalyzed Syntheses of Polysubstituted Tetrahydropyrroles, Tetrahydrofurans, and Cyclopentanes from Ene‐2‐Dienes.
Authors: Li Qian , Yu Zhi‐Xiang
Published: July 2010

The first example of conjugated diene‐assisted activation of an allylic C—H bond and its addition to alkenes is reported.
ChemInform Abstract: Cross Coupling in Water: Suzuki—Miyaura Vinylation and Difluorovinylation of Arylboronic Acids.
Authors: Pschierer Jan , Peschek Natalie , Plenio Herbert
Published: July 2010

A general and efficient protocol for the Suzuki—Miyaura vinylation of arylboronic acids in aqueous media is developed utilizing a catalyst system consisting of Na2PdCl4 and the commercially available, water‐soluble fluorenylphosphine ligand cataCXium F sulf.
ChemInform Abstract: Heterogeneous Asymmetric Henry Reaction Using a Chiral Bis(oxazoline)‐Copper Complex Immobilized on Magnetically Separable Mesocellular Mesoporous Silica Support.
Authors: Lee Jun‐Mun , Kim Jaeyun , Shin Yongje , Yeom Chang‐Eun , Lee Ji Eun , Hyeon Taeghwan , Kim B. Moon
Published: July 2010

A chiral bis(oxazoline) ligand is immobilized onto a magnetically separable hierarchically‐ordered mesocellular mesoporous silica (M‐HMMS) using click chemistry.
ChemInform Abstract: Efficient Aerobic Ruthenium‐Catalyzed Oxidation of Secondary Alcohols by the Use of a Hybrid Electron Transfer Catalyst.
Authors: Johnston Eric V. , Karlsson Erik A. , Tran Lien‐Hoa , Aakermark Bjoern , Baeckvall Jan‐E.
Published: July 2010

An efficient biomimetic catalyst system for the title reaction is developed.
ChemInform Abstract: Synthesis of Unnatural Amino Acid Derivatives via Palladium‐Catalyzed 1,4‐Addition of Boronic Acids
Authors: Ray Devalina , Nyong Abijah M. , Natarajan Amarnath
Published: July 2010

as possible inhibitors of protein—protein interactions
ChemInform Abstract: Synthesis and in vitro Antibacterial Evaluation of 1‐Substituted‐4‐ethoxycarbonylmethylthiosemicarbazides (III) and Products of Their Dehydrocyclization.
Authors: Siwek Agata , Stefanska Joanna , Wawrzycka‐Gorczyca Irena , Wujec Monika
Published: July 2010

The synthesized compounds are screened for their antibacterial activity, but only three of the tested substances show weak potency against Gram‐positive bacteria.
ChemInform Abstract: A Simple Synthesis of Pyrroles Catalyzed by Acidic Resin under Solvent‐Free Conditions.
Authors: Yuan Shizhen , Li Zhen , Xu Ling
Published: July 2010

A simple and effective Paal—Knorr condensation catalyzed by a macroporous strongly acidic styrene resin containing ‐SO3H groups (D001) is reported.
ChemInform Abstract: Dy(OTf)3/Pybox‐Catalyzed Enantioselective Friedel—Crafts Alkylation of Indoles with α,β‐Unsaturated Trifluoromethyl Ketones.
Authors: Sasaki Shigeru , Yamauchi Takayasu , Higashiyama Kimio
Published: July 2010

In most cases, good yields and enantioselectivities are obtained.
ChemInform Abstract: Direct Organocatalytic Asymmetric Aldol Reaction of α‐Isothiocyanato Imides to α‐Ketoesters under Low Ligand Loading: A Doubly Stereocontrolled Approach to Cyclic Thiocarbamates Bearing Chiral Quaternary Stereocenters.
Authors: Jiang Xianxing , Zhang Gen , Fu Dan , Cao Yiming , Shen Fangfang , Wang Rui
Published: July 2010

The title reaction provides a new and convenient method to prepare synthetically important cyclic thiocarbamates with good to high diastereo‐ and enantioselectivity.
ChemInform Abstract: Pd(II)‐Catalyzed Hydroxyl‐Directed C—H Olefination Enabled by Monoprotected Amino Acid Ligands.
Authors: Lu Yi , Wang Dong‐Hui , Engle Keary M. , Yu Jin‐Quan
Published: July 2010

The first examples for Pd(II)‐catalyzed C—H activation of alcohols are presented.
ChemInform Abstract: Catalyst‐Free Regioselective Synthesis of Benzopyran‐Annulated Thiopyrano[2,3‐b]thiochromen‐5‐(4H)‐one Derivatives by Domino‐Knoevenagel‐hetero‐Diels—Alder Reaction of Terminal Alkynes with 4‐Hydroxy Dithiocoumarin in Aqueous Medium.
Authors: Majumdar K. C. , Taher Abu , Ponra Sudipta
Published: July 2010

A simple one‐pot procedure allows the direct synthesis of the title compounds.
ChemInform Abstract: Radical Migration of Substituents of Aryl Groups on Quinazolinones Derived from N‐Acyl Cyanamides.
Authors: Larraufie Marie‐Helene , Courillon Christine , Ollivier Cyril , Lacote Emmanuel , Malacria Max , Fensterbank Louis
Published: July 2010

Two C—C and one C—N bonds are formed by an unprecedented radical cascade reaction involving the migration of ortho‐hydrogen or an ortho‐alkyl group at the phenyl ring of N‐benzoyl cyanamides to give pyrrolo‐ or pyrido‐fused quinazolinones.
ChemInform Abstract: Synthesis of 1,2‐Dihydro‐3‐benzoxepins by the Reaction of 2‐Lithio‐β‐methoxystyrenes with Epoxides Followed by Hydroiodic Acid Catalyzed Cyclization.
Authors: Kobayashi Kazuhiro , Hashimoto Hiroo , Nagaoka Toshiyuki , Shirai Yuu , Konishi Hisatoshi
Published: July 2010

The first general method for the synthesis of 1,2‐dihydro‐3‐benzoxepin derivatives (10 examples) is reported.
ChemInform Abstract: Overriding Felkin Control: A General Method for Highly Diastereoselective Chelation‐Controlled Additions to α‐Silyloxy Aldehydes.
Authors: Stanton Gretchen R. , Johnson Corinne N. , Walsh Patrick J.
Published: July 2010

Dialkylzincs, functionalized dialkylzincs, and in situ generated (E)‐di‐, (E)‐tri‐, and (Z)‐disubstituted vinylzinc species are added to aldehydes (I) with high selectivity for chelation‐controlled products in the presence of alkylzinc halides or triflates.
ChemInform Abstract: A Simple and Effective Synthesis of Activated Vinylphosphonates from 3‐Methoxy‐2‐diethoxyphosphorylacrylate.
Authors: Janecki Tomasz , Albrecht Anna , Koszuk Jacek F. , Modranka Jakub , Slowak Dominika
Published: July 2010

Substrate (I) reacts with nitrogen, carbon and phosphorus nucleophiles to give β‐substituted vinylphosphonates.
ChemInform Abstract: A Short Total Synthesis of (+)‐Omaezakianol via an Epoxide‐Initiated Cationic Cascade Reaction.
Authors: Xiong Zhaoming , Busch Robert , Corey E. J.
Published: July 2010

The key step in the synthesis of the title compound (III) is the transformation of the pentaepoxide (I) into the furan derivative (II).
ChemInform Abstract: Structural Revisions of Blumenol C Glucoside and Byzantionoside B.
Authors: Matsunami Katsuyoshi , Otsuka Hideaki , Takeda Yoshio
Published: July 2010

A modified Mosher′s method is used for the determination of the absolute stereochemistry of blumenol C glucoside (I) and byzantionoside B (II).
ChemInform Abstract: Synthesis and Investigation of the Biological Properties of 6‐Oxa‐8α‐analogues of Steroid Estrogenes Containing a Methyl Group at C‐4.
Authors: Morozkina S. N. , Selivanov S. S. , Selivanov S. I. , Drozdov A. S. , Eshchenko N. D. , Shavva A. G.
Published: July 2010

It is found that the introduction of a methyl group in position C‐4 of steroids leads to a loss of uterotropic and hypertriglyceridemic effects.
ChemInform Abstract: Rapid Access to Morphinones: Removal of 4,5‐Ether Bridge with Pd‐Catalyzed Triflate Reduction.
Authors: Hupp Christopher D. , Neumeyer John L.
Published: July 2010

A new alternative route to remove the 4,5‐ether bridge of opoids (I) includes an opoid‐4‐triflate intermediate and subsequent Pd‐catalyzed reduction.
ChemInform Abstract: PTSA‐Catalyzed Tandem Cyclization Protocol for the Stereoselective Total Synthesis of Obolactone.
Authors: Krishna Palakodety Radha , Srinivas Palabindela
Published: July 2010

The known alcohol (I), readily available from homopropargyl alcohol, is transformed to the diketone (II).
ChemInform Abstract: Carbon Nanotubes: Solid‐phase Extraction
Authors: Ravelo‐Perez Lidia M. , Herrera‐Herrera Antonio V. , Hernandez‐Borges Javier , Rodriguez‐Delgado Miguel Angel
Published: July 2010

Review: 181 refs.
ChemInform Abstract: Polyfluorinated Ligand‐Supported Organometallic Complexes of Copper, Silver, and Gold
Authors: Dias H. V. Rasika
Published: July 2010

Review: 49 refs.
ChemInform Abstract: Organocatalytic Oxidative Cleavage of Carbon—Carbon Double Bonds
Authors: Miyamoto Kazunori , Ochiai Masahito
Published: July 2010

Review: 93 refs.
ChemInform Abstract: Selective Syntheses of Functionalized Cyclic β‐Amino Acids via Transformation of the Ring C—C Double Bonds
Authors: Kiss Lorand , Fueloep Ferenc
Published: July 2010

Review: 76 refs.
ChemInform Abstract: Origin of Primitive Cells: From Nutrient Intake to Elongation of Encapsulated Nucleotides
Authors: Meierhenrich Uwe J. , Filippi Jean‐Jacques , Meinert Cornelia , Vierling Pierre , Dworkin Jason P.
Published: July 2010

Review: 83 refs.
ChemInform Abstract: Design and Characterization of Partially Fluorinated Lipid Liquid‐Crystal Membranes as Biomaterials
Authors: Takagi Toshiyuki , Takai Katsuki , Baba Teruhiko , Kanamori Toshiyuki
Published: July 2010

Review: 55 refs.
ChemInform Abstract: Non‐Ionic Surfactants in Analytical Chemistry
Authors: Pino Veronica , Afonso Ana M.
Published: July 2010

Review: 350 refs.
Thinking, feeling and deciding: The influence of emotions on the decision making and performance of traders
Authors: Fenton‐O'Creevy Mark , Soane Emma , Nicholson Nigel , Willman Paul
Published: July 2010

We report on a qualitative investigation of the influence of emotions on the decision making of traders in four City of London investment banks, a setting where work has been predominantly theorized as dominated by rational analysis. We conclude that emotions and their regulation play a central role in traders' decision making. We find differences between high and low performing traders in how they engage with their intuitions, and that different strategies for emotion regulation have material consequences for trader behavior and performance. Traders deploying antecedent‐focused emotional regulation strategies achieve a performance advantage over those employing primarily response‐focused strategies. We argue that, in particular, response‐focused approaches incur a performance penalty, in part because of the reduced opportunity to combine analysis with the use of affective cues in making intuitive judgments. We discuss the implications for our understanding of emotion and decision making, and for traders' practice. Copyright © 2010 John Wiley & Sons, Ltd.
Einblick in die Funktion der Nicht‐Gene – das Encode‐Projekt
Authors: Groß Michael
Published: July 2010

Nur ein Prozent unseres Genoms besteht aus Genen. Der Rest wurde lange Zeit als DNA‐Müll abgetan. Eine Pilotstudie zeigt nun, dass diese 99 Prozent – repräsentiert durch eine einprozentige Stichprobe – reich an Funktionselementen sind. Wir haben ihre Bedeutung nur noch nicht verstanden.
Phasenoptimierte LC – Beispiel Sprengstoffe
Authors: Engewald Werner , Matysik Fank‐Michael , Schumann Ulrike
Published: July 2010

Ein segmentiertes Kartuschensäulensystem für die HPLC optimiert Analysenzeit und Auflösung bei schwierigen Trennaufgaben, etwa bei der Analyse von Explosivstoffen und sprengstofftypischen Verbindungen. Zusätzlich machen ein UV‐Detektor und ein elektrochemischer Detektor, kombiniert eingesetzt, die Analysenergebnisse zuverlässiger.
Biologische Wirkung direkt messen
Authors: Kreiß Wolfgang , Ebertz Günther , Weisemann Claus
Published: July 2010

Die chromatographische Wirkungsdetektion mit Biolumineszenz überwindet durch Sensorschichten die Kompatibilitätsbarriere zwischen instrumenteller Analytik und Bioassay.
Die Branche im Fokus
Authors: Schlimm Christian
Published: July 2010

Chemiker haben als Branchenanalysten bei Banken, Brokern oder Investmentgesellschaften ihr Fachwissen als Alleinstellungsmerkmal: Intern ernten sie bei fachlichen Fragen selten Widerspruch, und in der externen Kommunikation mit Unternehmensvertretern sind sie oft besser akzeptiert.
In ungewohnter Umgebung
Authors: Breuker Kathrin
Published: July 2010

Struktur, Faltung und Dissoziation von Proteinen in der Gasphase zu studieren, scheint wenig praktische Bedeutung zu haben. Doch tatsächlich können Proteine in dieser unnatürlichen Umgebung mit massenspektrometrischen Methoden identifiziert, charakterisiert, und die Architekturen von biologisch relevanten Proteinkomplexen untersucht werden.
Schwingende Gerüste und tanzende Wassermoleküle
Authors: Havenith‐Newen Martina
Published: July 2010

Molekülanregungen, die energetisch oberhalb des Mikrowellen‐ und unterhalb des Infrarotbereiches liegen, sind bisher wenig erforscht. Doch das Fenster in den Terahertzbereich öffnet sich: THz‐Spektroskopie liefert Informationen über die Strukturbildung in kristallinen Proben und erlaubt die direkte Messung der Solvatationsdynamik von Biomolekülen.
140 Jahre chemische Gesellschaften in Deutschland
Authors: Simons Arno
Published: July 2010

Der besondere Charakter der Gesellschaft Deutscher Chemiker liegt darin, dass sie für Mitglieder aus Wissenschaft und Industrie offen ist. Das ist durchaus nicht selbstverständlich: Bis 1945 gab es die Deutsche Chemische Gesellschaft als wissenschaftliche Gesellschaft und den Verein Deutscher Chemiker als Standes‐ und Berufsvertretung.
Oberflächenchemie, Knockout‐Mäuse und Magnetowiderstand
Authors: Freund Hans‐Joachim , Bruno Patrick , Remenyi Christian
Published: July 2010

Nach 19 Jahren erhält wieder ein deutscher Wissenschaftler den Chemie‐Nobelpreis: Gerhard Ertl für seine Untersuchungen zu Prozessen an Festkörperoberflächen. Der Nobelpreis für Physik geht an Albert Fert und Peter Grünberg. Beide hatten unabhängig voneinander den Riesenmagnetowiderstand entdeckt. Den Nobelpreis für Medizin erhalten Mario Capecchi, Martin Evans und Oliver Smithies.
Mensch und Umwelt schützen
Authors: Lahl Uwe
Published: July 2010

Chemikaliensicherheit und Chemikalienmanagement sowie der Pflanzenschutz haben Impulse aus der deutschen EU‐Ratspräsidentschaft erhalten.
Jahre mit Heinrich Wieland
Authors: Remenyi Christian
Published: July 2010

Rolf Huisgen promovierte 1943 bei Heinrich Wieland, 1952 trat er seine Nachfolge als Professor an der LMU München an. Die Nachrichten aus der Chemie sprachen mit Huisgen über seine Jahre mit Heinrich Wieland.
Das Parlament der Wissenschaft
Authors: Schmidt Karlheinz
Published: July 2010

Vom 5. November bis zum 3. Dezember werden die DFG‐Fachkollegien neu gewählt. Etwa 100 000 Wissenschaftlerinnen und Wissenschaftler bestimmen per Internet die Mitglieder der 48 einzelnen Gremien.
1. Jahrestreffen der Senior‐Expert Chemists
Authors: Bengs Holger
Published: July 2010

11. bis 13. November in Steinheim/Hanau
Characteristics, impact and treatment of 6000 headache attacks: The PAMINA study
Authors: Lieba‐Samall Doris , Wöberl Christian , Weberl Michael , Schmidtl Karin , Wöber‐Bingöll Çiçek ,   The PAMINA‐Study Group
Published: July 2010

The aim of this study was to prospectively evaluate the characteristics of headache attacks, their impact on daily activities as well as the type and efficacy of acute medication in patients with migraine.

We included 281 patients with episodic migraine (87% females, aged 41.2±12.1). All patients kept a headache diary for 3 months covering headache characteristics, therapy and questions adopted from the Headache Impact Test (HIT‐6) for rating the impact of each single headache attack (HIT‐6 s). For evaluating the efficacy of acute medication we compared triptans with other compounds using headache duration as outcome parameter.

Of 6051 headache attacks 52.8% fulfilled the ICHD‐II criteria of migraine. The HIT‐6 s score was 2.4±2.2 (range 0–6). It was lowest in untreated headaches (2.0±2.1) and highest in those treated with a combination of triptans and other compounds (4.1±2.0, p <0.001). Patients used triptans on 8.0% of all headache days, other compounds on 33.1%, a combination of both on 1.5% and no medication on 57.3% of the headache days. Migraine attacks of moderate or severe intensity treated with triptans alone lasted significantly shorter than those treated with other compounds (5.1±3.6 vs. 6.9±5.3 h, p <0.001).

In conclusion, almost 50% of the headaches occurring in patients with migraine do not fulfill migraine criteria. Use of triptans is associated with a shorter duration of moderate and severe migraine attacks compared to use of other compounds.
RETRACTED: Transcription factor activator protein‐2β accelerates lipid accumulation in macrophages via enhancing the transcription of CD36
Authors: Gan Lu , Zhu Dongxing , Ding Zhenhua
Published: July 2010

There is no clarity about the authorship of this paper .
Trigger factor lacking the PPIase domain can enhance the folding of eukaryotic multi‐domain proteins in Escherichia coli
Authors: Gupta Rashmi , Lakshmipathy Sathish Kumar , Chang Hung-Chun , Etchells Stephanie A. , Hartl F. Ulrich
Published: July 2010

Recombinant expression of eukaryotic proteins in bacteria often results in misfolding and aggregation. The ribosome‐binding Trigger factor (TF) is the first molecular chaperone that interacts with nascent polypeptide chains in bacteria. Here we show that mutant TF lacking the PPIase domain (TFNC) is more efficient than wild‐type TF in enhancing the folding yield of multi‐domain proteins such as firefly luciferase. We find that TFNC has a shorter residence time on nascent chains, thus facilitating co‐translational folding. By delaying folding relative to translation, the PPIase domain may increase the propensity of misfolding for certain eukaryotic proteins that rely on a mechanism of co‐translational, domain‐wise folding.
From phenotype to gene: Detecting disease‐specific gene functional modules via a text‐based human disease phenotype network construction
Authors: Zhang Shi-Hua , Wu Chao , Li Xia , Chen Xi , Jiang Wei , Gong Bin-Sheng , Li Jiang , Yan Yu-Qing
Published: July 2010

Currently, some efforts have been devoted to the text analysis of disease phenotype data, and their results indicated that similar disease phenotypes arise from functionally related genes. These related genes work together, as a functional module, to perform a desired cellular function. We constructed a text‐based human disease phenotype network and detected 82 disease‐specific gene functional modules, each corresponding to a different phenotype cluster, by means of graph‐based clustering and mapping from disease phenotype to gene. Since genes in such gene functional modules are functionally related and cause clinically similar diseases, they may share common genetic origin of their associated disease phenotypes. We believe the investigation may facilitate the ultimate understanding of the common pathophysiologic basis of associated diseases.
Malfolded recombinant Tat substrates are Tat‐independently degraded in Escherichia coli
Authors: Lindenstrauß Ute , Matos Cristina F.R.O. , Graubner Wenke , Robinson Colin , Brüser Thomas
Published: July 2010

The twin‐arginine translocation (Tat) system translocates folded proteins across biological membranes. It has been suggested that the Tat system of Escherichia coli can direct Tat substrates to degradation if they are not properly folded [Matos, C.F., Robinson, C. and Di Cola, A. (2008) The Tat system proofreads FeS protein substrates and directly initiates the disposal of rejected molecules. EMBO J. 27, 2055–2063; Matos, C.F., Di Cola, A. and Robinson, C. (2009) TatD is a central component of a Tat translocon‐initiated quality control system for exported FeS proteins in Escherichia coli. EMBO Rep. 10, 474–479]. Contrary to the earlier reports, it is now concluded that reported differences between tested strains were due to variations in expression levels and inclusion body formation. Using the native Tat substrate NrfC and a malfolded variant thereof, we show that the turnover of these proteins is not affected by the absence of all known Tat components. Malfolded NrfC is degraded more quickly than the native protein, indicating that Tat‐independent protease systems can recognize malfolded Tat substrates.
Hypoesthesia in the Distal Residual Limb of Amputees
Authors: Harden R. Norman , Gagnon Christine M. , Khan Anjum , Wallach Gila , Zereshki Arzhang
Published: July 2010

Objective

To test the emerging hypothesis that there is polymodal fiber degeneration/loss in distal residual limbs (DRL) of amputees.

Design

Prospective qualitative and quantitative psychophysical testing.

Setting

A pain research center at an urban academic rehabilitation hospital.

Participants

Forty‐four amputees (32 with pain, 12 without pain) with a single (upper or lower) limb amputation. Subjects are a clinical “convenience” sample derived from our amputee or prosthetic clinics.

Methods

Interventions were prospectively acquired psychophysical tests. The primary quantitative test was thermal Quantitative Sensory Testing (tQST) using a Peltier type thermal testing device, assessing sites on the DRL compared with anatomically similar regions on the contralateral “unaffected” extremity.

Results

Perceptual responses for several qualitative psychophysical stimuli and perceptual thresholds for tQST cold sensation were significantly reduced in the DRL (t(43) = −2.613, P = .012). There were no significant tQST differences in thresholds for warm perception, cold pain, or hot pain (P > .05).

Conclusion

These results show a point prevalence of differential hypoesthesia in distal residual limbs. There was a selective loss of cold, but not warm perception or threshold for hot or cold pain by tQST. There are several possible explanations for this polymodal and selective hypoesthesia; specifically, these data may be indicative of a differential “dying back” peripheral neuropathy of the DRL, which may be operational in such clinical features as postamputation pain.
Skateboarding Injuries in Vienna: Location, Frequency, and Severity
Authors: Keilani Mohammad , Krall Christoph , Lipowec Lucas , Posch Martin , Komanadj Tanya Sedghi , Crevenna Richard
Published: July 2010

Objective

To describe injury patterns of skateboard‐associated injuries (SAIs) and to assess the frequency and severity of SAIs depending on an athlete's skateboarding experience.

Design

Cross‐sectional observation.

Setting

Skating areas.

Participants

A total of 100 Viennese skateboarders.

Interventions

No intervention.

Main Outcome Measures

The participants filled in a questionnaire that was used to assess selected sociodemographic data; duration and frequency of skateboarding; “stance”; and localization, rate, as well as the severity of SAIs during the past 24 months. Skating behavior and sociodemographic data were compared with frequency and severity of SAIs.

Results

Response rate of questionnaires was 75% (n = 75) of the participants. Duration of skateboarding was 8 ± 5 years, and training time was 18 ± 11 hours/week. A total of 97% (73) of the respondents reported at least one injury: in 52% (39) of the respondents the most serious injury was mild to moderate (laceration, contusion, strain/sprain, and bruise), whereas in 45% (34) it was severe (ligament rupture, fracture). A total of 33% (13) of participants experiencing only mild‐to‐moderate injuries consulted a physician compared with 94% (32) with at least one serious injury. The most severely affected regions were lower leg/ankle/foot in 32% (24) of all respondents who experienced at least one severe injury and forearm/wrist/hand in 16% (12) who experienced at least one severe injury. Only 13% (10) used protective equipment. Multivariate logistic regression for the occurrence of at least one severe injury with all socioeconomic and sport‐relevant data investigated revealed significant positive correlations with weekly training time (P = .037) and years of experience (P = .021). However, after correcting for multiple testing (Bonferroni adjustment for 8 tests), no significances remained.

Conclusion

More experienced skateboarders seem to have a greater risk of incurring severe SAIs, but sociodemographic factors seem to have no influence on injury risk in this population. Only a minority of skateboarders used protective equipment.