bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Capital Adequacy Ratio and Financing to Deposit Ratio Against Return on Assets and Return On Equity at Islamic Banks on Covid-19 Pandemic, Indonesia
Authors: Jauhari Burhanuddin , Respati Harianto , Sisharini Nanik
Published: April 2022

This study aims to analyze and explain the effect of the Capital Adequacy Ratio and Financing to Deposit Ratio Against Return on Assets and Return On Equity In Islamic Banks in Indonesia during the 2020 Covid-19 Pandemic Period. The research population is 12 Islamic commercial banks in Indonesia. A total of 11 Islamic commercial banks are the samples of this study. This study uses descriptive analysis techniques and linear regression to confirm the structural equation model and compare the paths between Return on Assets and Return On Equity. The quantitative approach was chosen to explain the effect of the research variables. We are collecting data using secondary data. The results of this study are the development of the Capital Adequacy Ratio and the ratio of Financing to Deposit Ratio will be followed by the development of the ratio of Return on Assets and the ratio of Return On Equity At Islamic Banks in Indonesia during the Covid-19 Pandemic Period.
Mindfulness in Strategic Decision-Making Process and its Impact on Organizational Performance: A case of Small and Medium Saudi Based Businesses
Authors: Alsuwayed Asmaa Ahmed
Published: April 2022

The prompt response to market changes, demands managers and employees to be flexible and perform multiple tasks, simultaneously. Mindfulness encouraged companies to be goal-oriented by improving attention to the present moment. Unexpected events faced by firms should be approached wisely to achieve organizational objectives. Hence, a strategic decision process should be coupled with mindfulness to make effective decisions that result in increased performance. There is limited empirical mindfulness research in the management discipline, particularly on whether mindfulness foster or impedes task performance in the workplace. Therefore, the purpose of the study was to develop a view as to “how do small and medium firms react in uncertain conditions by employing mindfulness in predicting and comprising problems in their strategic decision process to achieve objectives and enhance performance in the context of Saudi Arabia”. The findings enriched the comprehension of the effect of mindfulness in the strategic decision process on organizational performance.
Women Writers and Writing Women into Histories of Play for Today
Authors: Ball Vicky
Published: April 2022

This article emerges from a research project which explores the contribution women writers have made to Play for Today. The project seeks to use the flagship series as a case study, to highlight the significance of the single play in the histories of women’s work in television drama, to identify the attendant gender politics of television production which have contributed to the high levels of inequality therein and to critically analyse women’s creative contributions to the television play. There has been very little sustained research of these issues, to a great extent because of the association of the single play with masculinity. This sphere of drama production has, as this flagship series illustrates, been male-dominated: only 13 per cent of the Play for Today series were written by women, only 23 per cent were produced by women and only 4 per cent were directed by women. The critical neglect of women’s contributions to the single play has largely been attributed to the male-dominance of the industry and the attendant invisibility of women in archives ( Moseley and Wheatley 2008 ) and television drama histories ( Caughie 2000 ; Cooke 2003 , 2015 ). The aim of this article is to use Play for Today as a case study to cast new light on the contributions women have made to the single play, and concomitantly, the significance of Play for Today and the single play in historiographies of women writers and British television drama.
Scotch Missed: Play for Today and Scotland
Authors: Murray Jonathan
Published: April 2022

This article explores Scotland's relationship with and contribution to the Play for Today series. In order to quantify these, it proposes a working definition of ‘Scottishness’ based on representational content. This generates a body of 21 Scottish Plays for Today, which the article further breaks down into two sub-sets: seven plays produced outside Scotland and fourteen within. Noting that the externally produced plays are far better remembered and much more easily accessible than their locally produced peers, the article asks: do the external plays alone offer a reliable synecdoche for the terms of Scotland's contribution to Play for Today and the images and understandings of Scotland that Play for Today created and/or confirmed? Through extended comparative textual analysis of two externally produced plays –  Just Another Saturday and The Elephants’ Graveyard – and two locally produced ones –  Degree of Uncertainty and The Good Time Girls – the article demonstrates that the answer to this question is in the negative. The analyses presented here highlight the extent to which the 1970s work of writer Peter McDougall is far more formally and tonally complex than its contemporary popular and critical reputations might suggest. They also highlight the existence of an extended engagement with feminist gender politics and identities within Scottish screen fiction from an earlier date than conventionally identified within the established scholarly consensus. In these ways, the article addresses multiple aspects of Scottish screen and cultural studies’ long-term neglect of television's position and significance within modern Scottish culture and cultural history.
The effectiveness of the use of fifth-generation adhesive systems if changing the protocol before and after thermal cycling
Authors: Khaskhanova L. M. , Razumova S. N. , Brago A. S. , Bragunova R. M. , Guryeva Z. A. , Razumov N. M.
Published: April 2022

Fifth-generation adhesives are very popular in daily clinical practice. They have reduced number of components by combining a primer and an adhesive in a «single bottle». These adhesives have become more popular due to the reduction of application stages, but their adhesion strength to dentin turned out to be worse than that of the fourth-generation adhesives. The main mechanisms of adhesion of any dental material: moistening of the surface, micromechanical adhesion, chemical adhesion.

Aim. To evaluate the bond strength of tooth tissues with the filling material using different fifth-generation adhesive protocols.

Materials and methods. We used the 40 exctracted teeth due to orthodontic indications (molars and premolars). In preparation for the experiment the teeth were randomly divided into 2 equal groups according to the number of adhesive protocols used: control and main. The teeth surfaces (n=20) of the control group were treated according to the instructions, the surface treatment with a moistening agent was added to the protocol of teeth surfaces (n=20) in the main group before applying the adhesive. After curing of the adhesive a 3×3 steel detachable cylindrical mold was installed on the surface of the samples (n=40) of both groups filled with a composite paste. The prepared samples of the control (n=10) and main (n=10) groups of 2 subgroups were subjected to thousands (1000s) thermocycles with a temperature of (5±2) °C and (60±2) °C. Tests of the adhesive shear bond strength of the prepared (n=40) samples of the control (n=20) and main (n=20) groups before and after thermocycling were carried out on a universal testing machine SYNTHEZ 5.

Conclusion: Thermocycling provides the reliable adhesion but reduces the adhesive strength of the filling material with hard tissues of the tooth. Adding of moisturizing agent into the protocol leads to a decrease in the adhesion strength up to 15% compared to 7% in protocol without it.
Histological justification of the application of materials based on biomodified hyaluronic acid in combination with xenogenic osteoplastic material for maxillary alveolar bone augmentation before dental implantation
Authors: Tarasenko S. V. , Shehter A. B. , Golovichev M. E. , Oganesyan I. R.
Published: April 2022

The objective of the present study was the comparative evaluation of the effectiveness of using the composition of xenogenic osteoplastic material and materials based on biomodified hyaluronic acid for maxillary alveolar bone augmentation before dental implantation based on the results of histological investigations. The material for the study was bone tissue biopsies obtained with the use of a trephine at the stage of installation of the dental implants. The 4 micron sections prepared with a microtome were examined under different modes of light microscopy: bright field, dark field, phase contrast and polarization. The results of the study gave evidence of the formation of the endogenous bone tissue instead of the osteoplastic material in both the experimental and the control groups of the patients. Using of the xenogenic osteoplastic material in combination with preparations of biomodified hyaluronic acid gave the best results during sinus lift operation, since in these cases the bone of the most mature structure was formed, and in most cases there were no fragments of the implanted osteoplastic material. Nevertheless, the quality of the bone regenerate made it possible to install dental implants 6 months after the sinus lift in all groups.
Total tooth loss and its treatment with removable dentures: features of the microbiota and mucosal immunity
Authors: Malyshev M. E. , Кerimkhanov К. А. , Iordanishvili A. K.
Published: April 2022

The prevention of denture stomatitis is an important measure in the clinic of orthopedic dentistry, because at present, in spite of the availability of dentures on artificial supports, full removable dentures are still widely in demand. The study of oral microbiome and mucosal immunity in persons using full removable acrylic dentures was carried out, as it is important for scientifically substantiated development of ways to prevent denture stomatitis. Sixty-seven elderly patients with total tooth loss were examined and divided into 3 study groups. Patients in Group 1 (19 people) did not use any dentures. Patients in group 2 (25 people) had full removable acrylic dentures and from the first day of the adaptation period were offered to use the domestic denture fixation cream Acepta Parodontal. Patients of group 3 (23 people) were also made full removable acrylic dentures, but their adaptation period took place without the use of denture fixation cream. During the clinical-laboratory study it was established that the use of domestic Acepta Parodontal denture fixation cream in patients with full removable acrylic dentures during the adaptation period leads to a decrease in the level of inflammation in the oral cavity, contributes to an increase in mucosal immunity of its mucous membranes, as evidenced by the increased synthesis of secretory immunoglobulin A. At the same time, improvement of oral microbiota was noted, including reduction of detectability of Candida albicans as the main pathogen associated with denture stomatitis.
Individual anatomical variability of dental arches in the period of mixed dentition with optimal occlusal ratios
Authors: Davydov B. N. , Kochkonyan T. S. , Domenyuk D. A. , Dmitrienko T. D. , Domenyuk S. D.
Published: April 2022

Based on the results of a biometric study of plaster models of the jaws obtained in 84 children in the period of mixed dentition (8–12 years old) with a neutral location of the first permanent molars and optimal incisal overlap corresponding to the optimal functional occlusion of this age category, the main linear and angular parameters of the dental arches were determined with taking into account the trusive position of the incisors. Patients, taking into account the size of the inter-incisal angle, were divided into three groups. The first group (n=33) consisted of children with a mesotrusion position of the incisors (the value of the inter-incisor angle was 125–140°), the second group (n=27) consisted of children whose incisors were located protrusive (the value of the inter-incisor angle was less than 125°), the third group (n=24) – children with retrusion position of the incisors (the value of the inter-incisal angle is more than 140°). It has been established that in the period of mixed dentition, the main linear morphometric parameters of the dental arches are determined by the trusive types of the dental system and the vestibular-lingual inclination of the incisors. A diagnostically significant characteristic of the conjugation of the shape and size of the dental arches in the period of mixed dentition is the dental-diagonal coefficient, as the ratio of the length of the dental arch to the total component of the incisor-molar diagonals, the value of which for all types of dental systems is: for the upper jaw – 1.06 ± 0 .01; for the lower jaw – 1.09±0.01. It has been proven that in the period of mixed dentition the value of the incisal angle of the pentagon formed by the incisal diagonal and the width between the incisors is the smallest in children with protrusive incisors, while the parameters of the canine angle of the pentagon formed by the canine diagonal and the intercanine width are the largest in children with retrusion position of the incisors.
Bir Yeraltı Maden İşletmesindeki Kompresör Dairesi ve Basınçlı Hava İletim Hatlarının İş Sağlığı ve Güvenliği Açısından Değerlendirilmesi
Authors: ÇAKIR Alaaddin , DEMİRCAN Nejat , KARA Harun Ramazan , KOCABAŞ Sefa , DİLSİZ Günter
Published: April 2022

Günümüzde işletmelerde kompresör kullanımı çok yaygındır. Bu çalışmada bir yeraltı maden işletmesinin kompresör dairesi ve basınçlı hava iletim hatlarındaki tehlike ve riskler gürültü, aydınlatma ve kimyasal madde kullanımı başlıkları altında ele alınmıştır. Kompresör dairesinde alınan önlemler, kompresörler çalıştırılmadan önce uyulması gereken kurallar ile kullanılan kişisel koruyucu donanımlar, sağlık ve güvenlik işaretleri ile acil durum planları konularında bilgiler verilmiştir. Kompresörlere ve basınçlı hava iletim hatlarında uygulanan bakım onarım işlemleri ve periyodik kontrol konusu ayrıntılı olarak ele alınmıştır. Kompresörlerin gürültülü çalışan makinalar olması nedeniyle izolasyonlu bir çalışma ortamı sağlandığı ve kulak koruyucu donanım kullanımı ile tedbir alındığı görülmüştür. Kompresör kullanımında ihtiyaç duyulan kimyasal maddelerin kullanımında güvenlik bilgi formundaki bilgilere riayet edildiği ve kimyasallara dayanıklı kişisel koruyucu donanım kullanıldığı tespit edilmiştir. Ayrıca en son gerçekleştirilen periyodik kontrol raporunun önemli kısımları değerlendirilmiştir. Bu çalışma ile elde edilen bilgiler kompresör dairesi ve basınçlı hava iletim hatları için yapılacak risk değerlendirmesi çalışması için bir ön hazırlık niteliği taşımaktadır.
Avrupa Ülkelerinde Ölümlü İş Kazalarını Etkileyen Makroekonomik Faktörlerin Yatay Kesit Yöntemiyle Analizi
Authors: AYDIN Atilla
Published: April 2022

Dünyada her yıl iş kazaları nedeniyle yaklaşık 320 bin kişi yaşamını yitirmektedir. Bu noktada en büyük kayıp işçinin ölümüdür. Ancak işletmelerin ve devletlerin kaybı da dikkate alındığında, iş kazaları büyük bir sorun olarak görülmektedir. Bu nedenle son yıllarda iş sağlığı ve güvenliği konularında yapılan çalışmalar artmış ve artmaya devam etmektedir. İş sağlığı ve güvenliği konusunda yapılan akademik çalışmaların genellikle işletme düzeyinde yapıldığı görülmektedir. Bu çalışmada Avrupa ülkelerinde yaşanan iş kazalarını etkileyen makroekonomik faktörlerin ortaya çıkarılması amaçlanmıştır. Yatay kesit analizinin kullanıldığı çalışmada; enflasyon oranı, gini katsayısı ve sağlık harcamalarının Gayrisafi Yurtiçi Hasıla içindeki payının ölümlü iş kazaları üzerinde etkili olduğu sonucuna varılmıştır. Ayrıca belirleyici değişkenlerin tespit edilmesiyle birlikte ölümlü iş kazalarının azaltılmasına yönelik politika önerileri geliştirilmiştir.
FINITE ELEMENT ANALYSIS OF GUSSET PLATE CONNECTION DESIGN FOR COLD-FORMED STEEL FRAMES
Authors: Ng Aloysius Yoke Khing , Lee Yeong Huei , Ting Tina Chui Huon , Tan Cher Siang , Mohammad Shahrin
Published: April 2022

The application of cold-formed steel sections has been extended from secondary members to primary structural members in recent years. This increases the use of gusset plate connections in cold-formed steel since it is a common connection used in steel structures. However, current design codes on connection design do not have a comprehensive method to consider the effects due to the buckling of the thin cold-formed steel sections. Therefore, it is important to develop a more accurate model to predict the capacity of cold-formed steel connections. This paper aims to propose an equation for gusset plate beam-to-column connection using finite element models. Finite element models have been developed and compared with existing test results. The failure mode and ultimate strength of the numerical models are similar to the experimental results. The validated finite element models are then used to study the effects of gusset plate thickness, effects of cold-formed steel section depth and thickness, and the effects of bolt size and spacings. Elastic and plastic stiffnesses are obtained from the developed models. The connection behavior followed a typical elastic-plastic curve according to the connection ductility and failure mode. An empirical model is developed from the finite element models to predict the joint behavior of gusset plate beam-to-column connection for cold-formed steel structures. AS 4600 may have underestimated the initial stiffness of the connection.
The Mirage of Time Throughout Modern Physics: Scandalous Life of an Impostor
Authors: Jean-Claude Joseph
Published: April 2022

E. Schrodinger’s Quantum Mechanics taught us since early 20th Century a traumatizing lesson: bound electrons, atoms and molecules want nothing to do with the physical variable of time. In the same period, A. Einstein equally deflated the variable in his Relativistic analysis of astrophysics by showing its dependency on motion, mass and gravitation. His physics dilated time in order to keep it a workable concept in cosmology. These destabilizing visions of time always faced the obstacle of practical appeal and self-evidence the notion instills in everyone’s conscious experience. It thus never died in physics despite physicists’ increasing awareness of its problematic aura. Many today concede that time is not “fundamental”, yet the visualization of a macroscopic world bereft of time-driven phenomenology has not been successfully formulated if severally attempted. In this thesis, I show that the notion is vacuous by broadly reviewing it in Newtonian Physics, Relativity and Quantum Gravity.
Exegetical Phrase 'Keep Working On Your Salvation' According To Philippians 2:12
Authors: La"ia Apiyusu , Prasetyo Widi , Laurina Connie
Published: April 2022

Considering the influence of teaching in God's churches as well as writings on salvation are still contradictory, the writer must immediately write this paper with enthusiasm and joy. Anxiety occurs when among believers themselves still adhere to two to three understandings of salvation. First, there are those who argue that salvation is entirely from God and there is no human contribution in doing it. Because humans are sinners and do not have any reason for doing salvation. Second, there are those who argue that salvation is done by humans, God is only the provider. And the result is that many think that man will lose his salvation if he is not sincere in working for his salvation. Third, there are those who argue that salvation in Philippians 2:12 is a collaboration between God and man. God works and man must also work. Some of the focus problems above can produce good and bad qualities. Because there are some people who claim to believe but do not work out their salvation, but live as they please because they believe that the sins of the past, present and future sins of the Lord Jesus have been completed. Philippians 2:12 will consistently explore the true meaning, whether it is really God who works one hundred percent without human contribution or humans who have to work on salvation and God is the only provider.
Trusting God’s Redemption On Psalm 130: A Literary-Structure Approached
Authors: Chia Philip Suciadi , Juanda Juanda
Published: April 2022

The pressures of life that cause suffering are real things in life. The same thing happened to the psalmist recorded in Psalm 130:1-8. There are two big possibilities when someone faces a problem, they will move away from God or draw closer to God. In the narrative of Psalm 130:1-8, the psalmist draws closer to God. When the psalmist trusting God’s redemption generates the attitude to wait upon the Lord. Although God has not heard my prayer yet, I want to trust the Lord that he will deliver me despite I do not know when he will release me. I want to live in trust to the Lord because I believe that my faith will help me to endure in my problems, to still wait upon the Lord. I want to remember his characters so that I do not want to lose my faith in the midst of my suffering. This Psalm is begun with petition to the Lord and it is ended up by describing God’s characteristic.
Convolutional Neural Networks for Very Low-Dimensional LPV Approximations of Incompressible Navier-Stokes Equations
Authors: Heiland Jan , Benner Peter , Bahmani Rezvan
Published: April 2022

The control of general nonlinear systems is a challenging task in particular for large-scale models as they occur in the semi-discretization of partial differential equations (PDEs) of, say, fluid flow. In order to employ powerful methods from linear numerical algebra and linear control theory, one may embed the nonlinear system in the class of linear parameter varying (LPV) systems. In this work, we show how convolutional neural networks can be used to design LPV approximations of incompressible Navier-Stokes equations. In view of a possibly low-dimensional approximation of the parametrization, we discuss the use of deep neural networks (DNNs) in a semi-discrete PDE context and compare their performance to an approach based on proper orthogonal decomposition (POD). For a streamlined training of DNNs directed to the PDEs in aFinite Element(FEM) framework, we also discuss algorithmical details of implementing the proper norms in general loss functions.
Fruit Pomaces as Functional Ingredients in Poultry Nutrition: A Review
Authors: Mnisi Caven Mguvane , Mhlongo Godfrey , Manyeula Freddy
Published: April 2022

Sustainable poultry intensification is economically constrained by several factors including high feed costs, which constitute more than 70% of total production costs. Functional feed ingredients such as fruit pomaces can be incorporated into poultry diets as natural sources of nutrients and biologically active substances to deliver sustainable production. Fruit pomaces are agro-industrial waste by-products that have no direct food value for humans. Their utilization as feed ingredients would reduce feed-food competitions, optimize poultry production systems, and promote environmental, economic, and social sustainability. Large quantities of fruit pomaces are generated and disposed in landfills or through incineration with little regard to the environment. Thus, their inclusion in poultry feeds could offer a long-term strategy to protect the environment. Valorising fruit pomaces to enhance poultry production would also contribute toward sustainable development goals and food security through the provision of affordable high-quality protein to the rapidly growing human population. Moreover, the use of fruit pomaces complements food production systems by ensuring that food animals are reared on human inedible feedstuffs. Thus, this review explores the nutritional composition and subsequent feeding values of various fruit pomaces, while examining their environmental benefits when used as feed ingredients in poultry nutrition. Furthermore, strategies that can be employed to negate the effect of anti-nutritional factors in the pomaces are presented. We postulate that the use of fresh or valorised fruit pomaces would improve poultry production and significantly reduce the amounts of waste destined for incineration and/or direct deposition in landfills.
Exploitation of Skin Microbiota in Wound Healing: Perspectives During Space Missions
Authors: Marvasi Massimiliano , Monici Monica , Pantalone Desirée , Cavalieri Duccio
Published: April 2022

Wound healing is slowed in Space. Microgravity and possible physical factors associated with Space affect alterations in fibroblast, matrix formation, dysregulation in apoptosis and inflammation. The microbial populations settled on skin, space modules, in space suits, are also playing a pivotal role, as wound healing is also affected by the microbial community. We propose a perspective that includes four domines for the application of human skin microbiota for wound healing in Space: The natural antimicrobial properties of the skin microbiota, the crosstalk of the skin microbiota with the immune system during wound healing, the contribution of the microbiota in precision medicine, and the role of gut-skin and gut-brain axes. A stronger understanding of the connections and metabolic network among bacteria, fungi, the host’s immune system and the host metabolism will support the basis for a better wound healing in Space.
Apicoplast Dynamics During Plasmodium Cell Cycle
Authors: Elaagip Arwa , Absalon Sabrina , Florentin Anat
Published: April 2022

The deadly malaria parasite, Plasmodium falciparum, contains a unique subcellular organelle termed the apicoplast, which is a clinically-proven antimalarial drug target. The apicoplast is a plastid with essential metabolic functions that evolved via secondary endosymbiosis. As an ancient endosymbiont, the apicoplast retained its own genome and it must be inherited by daughter cells during cell division. During the asexual replication of P. falciparum inside human red blood cells, both the parasite, and the apicoplast inside it, undergo massive morphological changes, including DNA replication and division. The apicoplast is an integral part of the cell and thus its development is tightly synchronized with the cell cycle. At the same time, certain aspects of its dynamics are independent of nuclear division, representing a degree of autonomy in organelle biogenesis. Here, we review the different aspects of organelle dynamics during P. falciparum intraerythrocytic replication, summarize our current understanding of these processes, and describe the many open questions in this area of parasite basic cell biology.
Toxoplasma gondii’s Basal Complex: The Other Apicomplexan Business End Is Multifunctional
Authors: Gubbels Marc-Jan , Ferguson David J. P. , Saha Sudeshna , Romano Julia D. , Chavan Suyog , Primo Vincent A. , Michaud Cynthia , Coppens Isabelle , Engelberg Klemens
Published: April 2022

The Apicomplexa are famously named for their apical complex, a constellation of organelles at their apical end dedicated to invasion of their host cells. In contrast, at the other end of the cell, the basal complex (BC) has been overshadowed since it is much less prominent and specific functions were not immediately obvious. However, in the past decade a staggering array of functions have been associated with the BC and strides have been made in understanding its structure. Here, these collective insights are supplemented with new data to provide an overview of the understanding of the BC inToxoplasma gondii. The emerging picture is that the BC is a dynamic and multifunctional complex, with a series of (putative) functions. The BC has multiple roles in cell division: it is the site where building blocks are added to the cytoskeleton scaffold; it exerts a two-step stretch and constriction mechanism as contractile ring; and it is key in organelle division. Furthermore, the BC has numerous putative roles in ‘import’, such as the recycling of mother cell remnants, the acquisition of host-derived vesicles, possibly the uptake of lipids derived from the extracellular medium, and the endocytosis of micronemal proteins. The latter process ties the BC to motility, whereas an additional role in motility is conferred by Myosin C. Furthermore, the BC acts on the assembly and/or function of the intravacuolar network, which may directly or indirectly contribute to the establishment of chronic tissue cysts. Here we provide experimental support for molecules acting in several of these processes and identify several new BC proteins critical to maintaining the cytoplasmic bridge between divided parasites. However, the dispensable nature of many BC components leaves many questions unanswered regarding its function. In conclusion, the BC inT. gondiiis a dynamic and multifunctional structure at the posterior end of the parasite.
A Rare Case of Isolated Right Ventricular Non-compaction With the Novel TTN Mutation
Authors: Huang Piao-piao , Tang Ya-xin , Huang Xian-sheng
Published: April 2022

Isolated right ventricular non-compaction (RVNC) is rare yet life-threatening if left untreated, especially when accompanied by ventricular tachycardia. We describe a rare case of isolated RVNC, presenting as a prominent and excessive trabeculation of the right ventricle (RV), with an abnormal electrocardiogram. The transthoracic echocardiography, computed tomography, and ventricular angiography results clearly demonstrated an isolated spongy RV, both anatomically and functionally. Genetic testing identified a missense mutation of TTN. Combined, the diagnosis of RVNC was established. The subsequent combination of heart failure therapy, antiarrhythmic, and anticoagulation therapy were effective with a favorable outcome. This case report describes the possible etiology, manifestation, characteristic images, and problematic diagnostic criteria of the isolated RVNC. This case also emphasizes the necessity for comprehensive cardiac screening in familial cardiomyopathy.
N6-Methyladenosine RNA Methylation in Cardiovascular Diseases
Authors: Liu Chi , Gu Lei , Deng Wenjuan , Meng Qianchao , Li Nan , Dai Guifeng , Yu Suli , Fang Hong
Published: April 2022

N6-methyladenosine (m6A) modification is the most universal and abundant post-transcriptional modification of eukaryotic RNA and occurs mainly at the consensus motif RR (m6A) CH (R = A or G, H = A, C, or U) in long internal exons, near stop codons, or in the 3′ untranslated region (UTR). “Writers,” “erasers,” and “readers” are responsible for the occurrence, removal, and recognition of m6A modification, respectively. Substantial evidence has shown that m6A RNA modification can exert important functions in physiological and pathological processes. Cardiovascular diseases (CVDs) are a wide array of disorders affecting heart or vessels, including atherosclerosis (AS), hypertension (HT), ischemia/reperfusion (I/R) injury, myocardial infarction (MI), stroke, cardiac hypertrophy, heart failure (HF), and so on. Despite the advances in lipid-lowering drugs, antihypertensives, antiplatelet agents, and anticoagulation therapy, CVDs are still the leading cause of death worldwide. Recent studies have suggested that m6A modification of RNA may contribute to the pathogenesis of CVDs, providing a novel research insight for CVDs. Herein, we provide an up-of-date summarization of the molecular mechanism of m6A and the roles of m6A in different types of CVDs. At last, we propose that m6A might be a potiential biomarker or therapeutic target for CVDs.
Improving Data Quality in Clinical Research Informatics Tools
Authors: AbuHalimeh Ahmed
Published: April 2022

Maintaining data quality is a fundamental requirement for any successful and long-term data management. Providing high-quality, reliable, and statistically sound data is a primary goal for clinical research informatics. In addition, effective data governance and management are essential to ensuring accurate data counts, reports, and validation. As a crucial step of the clinical research process, it is important to establish and maintain organization-wide standards for data quality management to ensure consistency across all systems designed primarily for cohort identification, allowing users to perform an enterprise-wide search on a clinical research data repository to determine the existence of a set of patients meeting certain inclusion or exclusion criteria. Some of the clinical research tools are referred to as de-identified data tools. Assessing and improving the quality of data used by clinical research informatics tools are both important and difficult tasks. For an increasing number of users who rely on information as one of their most important assets, enforcing high data quality levels represents a strategic investment to preserve the value of the data. In clinical research informatics, better data quality translates into better research results and better patient care. However, achieving high-quality data standards is a major task because of the variety of ways that errors might be introduced in a system and the difficulty of correcting them systematically. Problems with data quality tend to fall into two categories. The first category is related to inconsistency among data resources such as format, syntax, and semantic inconsistencies. The second category is related to poor ETL and data mapping processes. In this paper, we describe a real-life case study on assessing and improving the data quality at one of healthcare organizations. This paper compares between the results obtained from two de-identified data systems i2b2, and Epic Slicedicer, and discuss the data quality dimensions' specific to the clinical research informatics context, and the possible data quality issues between the de-identified systems. This work in paper aims to propose steps/rules for maintaining the data quality among different systems to help data managers, information systems teams, and informaticists at any health care organization to monitor and sustain data quality as part of their business intelligence, data governance, and data democratization processes.
Bridging the Technological Divide: Stigmas and Challenges With Technology in Digital Brain Health Studies of Older Adults
Authors: Nicosia Jessica , Aschenbrenner Andrew J. , Adams Sarah L. , Tahan Marisol , Stout Sarah H. , Wilks Hannah , Balls-Berry Joyce E. , Morris John C. , Hassenstab Jason
Published: April 2022

The COVID-19 pandemic has increased adoption of remote assessments in clinical research. However, longstanding stereotypes persist regarding older adults' technology familiarity and their willingness to participate in technology-enabled remote studies. We examined the validity of these stereotypes using a novel technology familiarity assessment (n = 342) and with a critical evaluation of participation factors from an intensive smartphone study of cognition in older adults (n = 445). The technology assessment revealed that older age was strongly associated with less technology familiarity, less frequent engagement with technology, and higher difficulty ratings. Despite this, the majority (86.5%) of older adults elected to participate in the smartphone study and showed exceptional adherence (85.7%). Furthermore, among those enrolled, neither technology familiarity, knowledge, perceived difficulty, nor gender, race, or education were associated with adherence. These results suggest that while older adults remain significantly less familiar with technology than younger generations, with thoughtful study planning that emphasizes participant support and user-centered design, they are willing and capable participants in technology-enabled studies. And once enrolled, they are remarkably adherent.
Psychosocial Impacts of Mobile Game on K12 Students and Trend Exploration for Future Educational Mobile Games
Authors: Li Yuanzhe , Xu Zezheng , Hao Yu , Xiao Peng , Liu Jingyan
Published: April 2022

Due to the popularity and advancement of 4G/5G networks, mobile games have already currently become profitable tools for major internet platforms. These games are even refined to cover almost all age groups of the population rather than the young people. Yet in the perception of the public, mobile games have always seemed to be associated with various derogatory terms such as interfering with learning, addiction, and violence. K12 students usually have less self-control capability, and they are undoubtedly the biggest advocates of mobile games. This paper summarizes the technological development of mobile games from the aspects of hardware and software in chronological order. The psychological and social problems that mobile games have brought to K12 students are analyzed from a neutral perspective. At the end of the paper, the future development of educational games and current limitations of mobile games are also given for the explorations of future trends of game-based education. This position paper aims to provide the insight of what psychosocial impacts that the current mobile games have on the student, and it may also serve as a reference for the how the game-based education has been developing according to the mobile technology wise.
The Way We Teach Now: Exploring Resilience and Teacher Identity in School Teachers During COVID-19
Authors: Ramakrishna Madhumita , Singh Purnima
Published: April 2022

With the sudden onset of the COVID-19 pandemic, teachers across the globe felt the need to respond overnight to unprecedented adversity. Rapid adaptation to unfamiliar modes of teaching was required, leading teachers to face overwhelm on two fronts–adapting to a global pandemic, and teaching in the absence of resources and infrastructure. The lack of a physical classroom and face-to-face interaction also impacted a teachers’ sense of purpose and identity. Shifts in teacher identity affect their motivation, commitment, job satisfaction, and self-image, which collectively influences their resilience. By focusing on the impact of COVID-19 on their teaching experience, this study attempted to understand the resilience of the teaching community while exploring the social and emotional factors that helped them adapt. Using the Life Story Interview method, 20 school teachers in the Delhi National Capital Region were asked to reflect on their teaching experiences during the lockdown to explore their resilience in adapting to a new reality. Reflexive thematic analysis revealed adjustment to change and loss, disengagement, and recognising small victories as themes.
Functional Ovarian Cysts in Artificial Frozen-Thawed Embryo Transfer Cycles With Depot Gonadotropin-Releasing Hormone Agonist
Authors: Ji Hui , Su Yan , Zhang Mianqiu , Li Xin , Li Xiuling , Ding Hui , Dong Li , Cao Shanren , Zhao Chun , Zhang Junqiang , Shen Rong , Ling Xiufeng
Published: April 2022

Objectives

To investigate the incidence of functional ovarian cysts, its influence on clinical rates, and proper management after depot gonadotropin-releasing hormone (GnRH) agonist pretreatment in artificial frozen-thawed embryo transfer cycles (AC-FET).

Methods

This retrospective cohort study involved 3375 AC-FET cycles with follicular-phase depot GnRH agonist administration between January 2017 and December 2020. Subjects were divided into a study group (cycles with cyst formation) and a control group (cycles without cyst formation). The study group was matched by propensity scoring matching with the control group at a ratio of 1:2. For patients with ovarian cyst formation, two major managements were used: a conservative approach (i.e., expectant treatment) and a drug approach (i.e., continued agonist administration). The primary outcome was live birth rate (LBR).

Results

The incidence of functional ovarian cysts following pituitary downregulation is 10.1% (341/3375). The study group exhibited a LBR similar to the control group (54.5% vs. 50.1%, adjusted odds ratio [aOR] 1.17, 95% confidence interval [CI] 0.88–1.56, P = 0.274). Patients with a lower body mass index and anti-Müllerian hormone, and a higher basal estradiol level were more susceptible to developing functional ovarian cysts. The LBR decreased after the drug approach compared with the conservative approach, but not significantly (aOR 0.63, 95% CI 0.35–1.14, P = 0.125). Following the conservative approach, cycles arrived at live births had a significantly shorter duration from the detection of functional cysts to the start of endometrium preparation (15.7 ± 5.1 days vs. 17.4 ± 5.3 days, P = 0.009) and a significantly higher proportion of ovarian cysts on the initial day of exogenous hormone supplementation (51.4% vs. 30.3%, P = 0.001). After controlling for all confounders, the differences remained statistically significant.

Conclusions

It is unnecessary to cancel cycles that experience functional ovarian cyst formation. Conservative management and further agonist suppression protocol had similar pregnancy rates. However, a conservative approach was recommended due to its lower cost and fewer side effects. Our findings support a shorter waiting period when choosing the conservative protocol.
Heterozygous Genetic Variants in Autosomal Recessive Genes of the Leptin-Melanocortin Signalling Pathway Are Associated With the Development of Childhood Obesity
Authors: Šket Robert , Kotnik Primož , Bizjan Barbara Jenko , Kocen Valentina , Mlinarič Matej , Tesovnik Tine , Debeljak Maruša , Battelino Tadej , Kovač Jernej
Published: April 2022

Monogenic obesity is a severe, genetically determined disorder that affects up to 1/1000 newborns. Recent reports on potential new therapeutics and innovative clinical approaches have highlighted the need for early identification of individuals with rare genetic variants that can alter the functioning of the leptin-melanocortin signalling pathway, in order to speed up clinical intervention and reduce the risk of chronic complications. Therefore, next-generation DNA sequencing of central genes in the leptin-melanocortin pathway was performed in 1508 children and adolescents with and without obesity, aged 2-19 years. The recruited cohort comprised approximately 5% of the national paediatric population with obesity. The model-estimated effect size of rare variants in the leptin-melanocortin signalling pathway on longitudinal weight gain between carriers and non-carriers was derived. In total, 21 (1.4%) participants had known disease-causing heterozygous variants (DCVs) in the genes under investigation, and 62 (4.1%) participants were carriers of rare variants of unknown clinical significance (VUS). The estimated frequency of potential genetic variants associated with obesity (including rare VUS) ranged between 1/150 (VUS and DCV) and 1/850 (DCV) and differed significantly between participants with and without obesity. On average, the variants identified would result in approximately 7.6 kg (7.0-12.9 kg at the 95th percentile of body weight) (girls) and 8.4 kg (8.2-14.4 kg) (boys) of additional weight gain in carriers at age 18 years compared with subjects without obesity. In conclusion, children with a genetic predisposition to obesity can be promptly identified and may account for more than 6% of obesity cases. Early identification of genetic variants in the LEPR, PCSK1, POMC, MC3R and MC4R genes could reduce the societal burden and improve the clinical management of early severe childhood obesity and its implementation should be further investigated.
Association Between Iron Metabolism and Acute Kidney Injury in Critically Ill Patients With Diabetes
Authors: Mo Manqiu , Gao Yunqing , Deng Ling , Liang Yuzhen , Xia Ning , Pan Ling
Published: April 2022

Objective

Iron overload plays an important role in the pathogenesis of diabetes and acute kidney injury (AKI). The aim of this present study was to explore the relationship between iron metabolism and AKI in patients with diabetes.

Methods

The clinical data of diabetes patients from MIMIC-III database in intensive care unit (ICU) were retrospectively analyzed. Regression analyses were used to explore the risk factors of AKI and all-cause death in critical patients with diabetes. Area under the receiver operating characteristic curves (AUROCs) were used to analyze serum ferritin (SF), and regression model to predict AKI in critical patients with diabetes. All diabetes patients were followed up for survival at 6 months, and Kaplan–Meier curves were used to compare the survival rate in patients with different SF levels.

Results

A total of 4,997 diabetic patients in ICU were enrolled, with a male-to-female ratio of 1.37:1 and a mean age of 66.87 ± 12.74 years. There were 1,637 patients in the AKI group (32.8%) and 3,360 patients in the non-AKI group. Multivariate logistic regression showed that congestive heart failure (OR = 2.111, 95% CI = 1.320–3.376), serum creatinine (OR = 1.342, 95% CI = 1.192–1.512), Oxford Acute Severity of Illness Score (OR = 1.075, 95% CI = 1.045–1.106), increased SF (OR = 1.002, 95% CI = 1.001–1.003), and decreased transferrin (OR = 0.993, 95% CI = 0.989–0.998) were independent risk factors for AKI in critical patients with diabetes. Multivariate Cox regression showed that advanced age (OR = 1.031, 95% CI = 1.025–1.037), AKI (OR = 1.197, 95% CI = 1.011–1.417), increased Sequential Organ Failure Assessment score (OR = 1.055, 95% CI = 1.032–1.078), and increased SF (OR = 1.380, 95% CI = 1.038–1.835) were independent risk factors for 6-month all-cause death in critical diabetic patients. The AUROCs of SF and the regression model to predict AKI in critical patients with diabetes were 0.782 and 0.851, respectively. The Kaplan–Meier curve showed that the 6-month survival rate in SF-increased group was lower than that in SF-normal group (log-rank χ2 = 16.989, P < 0.001).

Conclusion

Critically ill diabetic patients with AKI were easily complicated with abnormal iron metabolism. Increase of SF is an important risk factor for AKI and all-cause death in critically ill patients with diabetes.
Distributed Resilient Mitigation Strategy for False Data Injection Attack in Cyber-Physical Microgrids
Authors: Cao Ge , Jia Rong , Dang Jian
Published: April 2022

The stable and reliable operation of microgrids requires the immediate communication and accurate measuring data of cyber systems. The cyber security of smart grids consists of detection and mitigation, where the latter mainly refers to resisting the attack and recovering the physical operation state through various means after cyber attacks. With the flexible electrical topology and the distributed control strategy based on the public communication network and end-to-end neighbor communication, the application and effect of cyber security technologies (firewall and encryption) in traditional cyber systems are limited. However, due to the fact that the cyber system and power system are coupled in microgrid cooperative control, countermeasures are added to the control to enhance the cyber security of microgrids, which has drawn more attention. Therefore, considering the control failure and even system results from the false data inject attack (FDIA) on the cooperative control of microgrids, this study investigates the synchronous mitigation framework based on local detection where the reactive power cooperative control targets of microgrids with and without FDIA are compatible by the resilient control method. The credibility is utilized to measure the reliability of local and neighbor data in the proposed method. The consensus communication coupling gain is weighted corrected by an adaptive update strategy of credibility to delete the attack signal. Moreover, the proposed method directly improves the conventional distributed secondary controller that reduces the complexity of controller design. Simulations investigate the effectiveness of the proposed distributed resilient mitigation strategy under conditions of deception and disruption attacks.