bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterizing Håkon Mosby Mud Volcano (Barents Sea) cold seep systems by combining ROV-based acoustic data and underwater photogrammetry
Authors: Fallati Luca , Panieri Giuliana , Argentino Claudio , Varzi Andrea Giulia , Bünz Stefan , Savini Alessandra
Published: October 2023

Cold-seeps have a unique geo-ecological significance in the deep-sea environment. They impact the variability of present-day submarine sedimentary environments, affecting the evolution of the landscape over time and creating a variety of submarine landforms, one of which is Mud Volcanoes (MVs). MVs form due to the extrusion of mud, fluids, and gas, mainly methane, from deeper sedimentary layers. These natural gas seepage systems could significantly affect climate change and the global carbon cycle. We present a comprehensive method that combines ROV-based multibeam mapping and underwater photogrammetry to enhance the understanding of the physical relationships between geomorphic units characterizing the Håkon Mosby Mud Volcano (HMMV) and the distribution of associated habitats. HMMV is indeed characterized by high thermal and geochemical gradients from its center to the margins resulting in a clear zonation of chemosynthetic communities. Our approach integrates multi-resolutions and multi-sources data acquired using a work-class ROV. The ROV-based microbathymetry data helped to identify the different types of fine-scale submarine landforms in the central part of HMMV. This revealed three distinct geomorphic units, with the central hummocky region being the most complex. To further study this area, ROV images were analyzed using a defined Structure from Motion workflow producing millimetric resolution 2D and 3D models. Object-Based Image Analysis (OBIA), applied on orthomosaics, allowed us to obtain a fine classification of main benthic communities covering a total area of 940m2, including the active seepage area of the hummocky rim. Four major substrate types were identified in these regions:uncovered mud, bacterial mats high-density, bacterial mats low-density, sediments and tubeworms. Their relationship with terrain morphology and seepage activity were investigated at different spatial scales, contributing to a deeper understanding the ecological functioning of cold seep ecosystems in MVs. The applied workflow is proposed as an innovative processing technique for future studies on cold-seep systems. Geomorphic and ecological processes in extreme environments are inherently linked and marked by spatial patterns typifying associated habitats and sedimentary environments. This is poorly investigated in previous studies, leaving a substantial gap in the geomorphological drivers responsible for habitat distribution and extent in cold seep systems.
Causal influences of osteoarthritis on COVID-19: a Mendelian randomization study
Authors: Fu Li , Baranova Ancha , Cao Hongbao , Zhang Fuquan
Published: October 2023

Objective

Although observational and genetic studies have indicated a correlation between OA and COVID-19, it remains uncertain whether osteoarthritis (OA) contributes to the severity of COVID-19. Here, we aimed to investigate the potential causal links between the two.

Methods

In this study, we conducted Mendelian randomization (MR) analysis to investigate whether there is a potential causal connection between OA and COVID-19 outcomes. The analysis utilized publicly available GWAS summary datasets, incorporating data on OA (N = 455,221), SARS-CoV-2 infection (N = 2,597,856), hospitalized COVID-19 (N = 2,095,324), and critical COVID-19 (N = 1,086,211). Additionally, we performed a literature analysis to establish a molecular network connecting OA and COVID-19.

Results

The MR analysis showed causal effects of OA on hospitalized COVID-19 (OR: 1.21, 95% CI: 1.02–1.43, p = 0.026) and critical COVID-19 (OR: 1.35, 95% CI: 1.09–1.68, p = 0.006) but not on SARS-CoV-2 infection as such (OR: 1.00, 95% CI: 0.92–1.08, p = 0.969). Moreover, the literature-based pathway analysis uncovered a set of specific genes, such as CALCA, ACE, SIRT1, TNF, IL6, CCL2, and others, that were found to mediate the association between OA and COVID-19.

Conclusion

Our findings indicate that OA elevates the risk of severe COVID-19. Therefore, larger efforts should be made in the prevention of COVID-19 in OA patients.
Noncoding rules of survival: epigenetic regulation of normal and malignant hematopoiesis
Authors: Wallace LaShanale , Obeng Esther A.
Published: October 2023

Hematopoiesis is an essential process for organismal development and homeostasis. Epigenetic regulation of gene expression is critical for stem cell self-renewal and differentiation in normal hematopoiesis. Increasing evidence shows that disrupting the balance between self-renewal and cell fate decisions can give rise to hematological diseases such as bone marrow failure and leukemia. Consequently, next-generation sequencing studies have identified various aberrations in histone modifications, DNA methylation, RNA splicing, and RNA modifications in hematologic diseases. Favorable outcomes after targeting epigenetic regulators during disease states have further emphasized their importance in hematological malignancy. However, these targeted therapies are only effective in some patients, suggesting that further research is needed to decipher the complexity of epigenetic regulation during hematopoiesis. In this review, an update on the impact of the epigenome on normal hematopoiesis, disease initiation and progression, and current therapeutic advancements will be discussed.
Piecing it together: atrophy profiles of hippocampal subfields relate to cognitive impairment along the Alzheimer’s disease spectrum
Authors: Christopher-Hayes Nicholas J. , Embury Christine M. , Wiesman Alex I. , May Pamela E. , Schantell Mikki , Johnson Craig M. , Wolfson Sara L. , Murman Daniel L. , Wilson Tony W.
Published: October 2023

Introduction

People with Alzheimer’s disease (AD) experience more rapid declines in their ability to form hippocampal-dependent memories than cognitively normal healthy adults. Degeneration of the whole hippocampal formation has previously been found to covary with declines in learning and memory, but the associations between subfield-specific hippocampal neurodegeneration and cognitive impairments are not well characterized in AD. To improve prognostic procedures, it is critical to establish in which hippocampal subfields atrophy relates to domain-specific cognitive declines among people along the AD spectrum. In this study, we examine high-resolution structural magnetic resonance imaging (MRI) of the medial temporal lobe and extensive neuropsychological data from 29 amyloid-positive people on the AD spectrum and 17 demographically-matched amyloid-negative healthy controls.

Methods

Participants completed a battery of neuropsychological exams including select tests of immediate recollection, delayed recollection, and general cognitive status (i.e., performance on the Mini-Mental State Examination [MMSE] and Montreal Cognitive Assessment [MoCA]). Hippocampal subfield volumes (CA1, CA2, CA3, dentate gyrus, and subiculum) were measured using a dedicated MRI slab sequence targeting the medial temporal lobe and used to compute distance metrics to quantify AD spectrum-specific atrophic patterns and their impact on cognitive outcomes.

Results

Our results replicate prior studies showing that CA1, dentate gyrus, and subiculum hippocampal subfield volumes were significantly reduced in AD spectrum participants compared to amyloid-negative controls, whereas CA2 and CA3 did not exhibit such patterns of atrophy. Moreover, degeneration of the subiculum along the AD spectrum was linked to a significant decline in general cognitive status measured by the MMSE, while degeneration scores of the CA1 and dentate gyrus were more widely associated with declines on the MMSE and tests of learning and memory.

Discussion

These findings provide evidence that subfield-specific patterns of hippocampal degeneration, in combination with cognitive assessments, may constitute a sensitive prognostic approach and could be used to better track disease trajectories among individuals on the AD spectrum.
A guide to Whittle maximum likelihood estimator in MATLAB
Authors: Roume Clément
Published: October 2023

The assessment of physiological complexity via the estimation of monofractal exponents or multifractal spectra of biological signals is a recent field of research that allows detection of relevant and original information for health, learning, or autonomy preservation. This tutorial aims at introducing Whittle’s maximum likelihood estimator (MLE) that estimates the monofractal exponent of time series. After introducing Whittle’s maximum likelihood estimator and presenting each of the steps leading to the construction of the algorithm, this tutorial discusses the performance of this estimator by comparing it to the widely used detrended fluctuation analysis (DFA). The objective of this tutorial is to propose to the reader an alternative monofractal estimation method, which has the advantage of being simple to implement, and whose high accuracy allows the analysis of shorter time series than those classically used with other monofractal analysis methods.
Outcomes among oropharyngeal and oral cavity cancer patients treated with postoperative volumetric modulated arctherapy
Authors: Mione Cécile , Casile Mélanie , Moreau Juliette , Miroir Jessica , Molnar Ioana , Chautard Emmanuel , Bernadach Maureen , Kossai Myriam , Saroul Nicolas , Martin F. , Pham-Dang Nathalie , Lapeyre Michel , Biau Julian
Published: October 2023

Background

Presently, there are few published reports on postoperative radiation therapy for oropharyngeal and oral cavity cancers treated with IMRT/VMAT technique. This study aimed to assess the oncological outcomes of this population treated with postoperative VMAT in our institution, with a focus on loco-regional patterns of failure.

Material and methods

Between 2011 and 2019, 167 patients were included (40% of oropharyngeal cancers, and 60% of oral cavity cancers). The median age was 60 years. There was 64.2% of stage IV cancers. All patients had both T and N surgery. 34% had a R1 margin, 42% had perineural invasion. 72% had a positive neck dissection and 42% extranodal extension (ENE). All patients were treated with VMAT with simultaneous integrated boost with three dose levels: 66Gy in case of R1 margin and/or ENE, 59.4-60Gy on the tumor bed, and 54Gy on the prophylactic areas. Concomittant cisplatin was administrated concomitantly when feasible in case of R1 and/or ENE.

Results

The 1- and 2-year loco-regional control rates were 88.6% and 85.6% respectively. Higher tumor stage (T3/T4), the presence of PNI, and time from surgery >45 days were significant predictive factors of worse loco-regional control in multivariate analysis (p=0.02, p=0.04, and p=0.02). There were 17 local recurrences: 11 (64%) were considered as infield, 4 (24%) as marginal, and 2 (12%) as outfield. There were 9 regional recurrences only, 8 (89%) were considered as infield, and 1 (11%) as outfield. The 1- and 2-year disease-free survival (DFS) rates were 78.9% and 71.8% respectively. The 1- and 2-year overall survival (OS) rates were 88.6% and 80% respectively. Higher tumor stage (T3/T4) and the presence of ENE were the two prognostic factors significantly associated with worse DFS and OS in multivariate analysis.

Conclusion

Our outcomes for postoperative VMAT for oral cavity and oropharyngeal cancers are encouraging, with high rates of loco-regional control. However, the management of ENE still seems challenging.
Segmentectomy for patients with early-stage pure-solid non-small cell lung cancer
Authors: Kamigaichi Atsushi , Hamada Akira , Tsutani Yasuhiro
Published: October 2023

For decades, lobectomy has been the recommended surgical procedure for non-small cell lung cancer (NSCLC), including for small-sized lesions. However, two recent pivotal clinical trials conducted by the Japanese Clinical Oncology Group/West Japan Oncology Group (JCOG0802/WJOG4607L) and the Cancer and Leukemia Group B (CALGB140503), which compared the survival outcomes between lobectomy and sublobar resection (the JCOG0802/WJOG4607L included only segmentectomy, not wedge resection), demonstrated the efficacy of sublobar resection in patients with early-stage peripheral lung cancer measuring ≤ 2 cm. The JCOG0802/WJOG4607L demonstrated the superiority of segmentectomy over lobectomy with respect to overall survival, implying the survival benefit conferred by preservation of the lung parenchyma. Subsequently, the JCOG1211 also demonstrated the efficacy of segmentectomy, even for NSCLC, measuring up to 3 cm with the predominant ground-glass opacity phenotype. Segmentectomy has become the standard of care for early-stage NSCLC and its indications are expected to be further expanded to include solid lung cancers > 2 cm. However, local control is still a major concern for segmentectomy for higher-grade malignant tumors. Thus, the indications of segmentectomy, especially for patients with radiologically pure-solid NSCLC, remain controversial due to the aggressive nature of the malignancy. In this study, we reviewed previous studies and discussed the efficacy of segmentectomy for patients with such tumors.
Comparing low-dose (DART) and enhanced low-dose dexamethasone regimens in preterm infants with bronchopulmonary dysplasia
Authors: Al-taweel Heba Mohamed , Abdelhady Ismail Sabry Ismail , Irfan Nasreen , Khzzam Fadi Al , Kamal Abdullah , Thazhe Sudheer Babu Kurunthattil , Bayoumi Mohammad A. A. , Gad Ashraf
Published: October 2023

Introduction

Determining the optimal dexamethasone dosage for facilitating extubation in extremely low birth weight (ELBW) infants with bronchopulmonary dysplasia (BPD) remains uncertain. This study aims to compare the effectiveness of low-dose (DART) and enhanced low-dose dexamethasone regimens in achieving successful extubation in these infants.

Methods

We conducted a retrospective cohort study at the Women's Wellness and Research Center (WWRC) involving ELBW infants who received dexamethasone for BPD prevention or treatment, or for extubation between January 1st, 2015, and December 31st, 2019. Our goal was to assess successful extubation within various time points of treatement.

Results

A total of 77 patients, matched in gestational age and BW, were enrolled in the study, receiving a total of 121 dexamethasone courses. Low-dose dexamethasone courses were administered 75 times to 49 infants, while 46 courses of enhanced low-dose were given to 28 infants. Treatment commenced at 30.8 ± 3.4 weeks post-menstrual age, compared to 32.1 ± 2.5 weeks in the enhanced low-dose group (p = 0.014). The median (IQR) course duration was seven (3–10) days in the low-dose group, while it was 10 (8–14) days in the enhanced low-dose group (p < 0.001). The median (IQR) course dose was 0.73 (0.53–0.86) mg/kg in the low-dose group and 1.27 (0.97–2.05) mg/kg in the enhanced low-dose group (p < 0.001). There were no differences in extubation success at any time point between the two groups at 72 h and seven days after treatment initiation, by course completion, and within seven days after treatment completion. However, regression analysis identified several predictors of successful extubation; baseline FiO2, course duration, and duration of invasive mechanical ventilation were negatively associated with successful extubation at various time points, while received dose per kg and cumulative dose positively correlated with successful extubation at different time points. No significant differences were observed in secondary outcomes, including death or BPD.

Conclusion

The choice between low-dose and enhanced low-dose dexamethasone regimens may not significantly impact extubation success. However, careful consideration of dosing, ventilation status, and treatment duration remains crucial in achieving successful extubation. This study highlights the need for personalized dexamethasone therapy in ELBW infants.
PARP inhibitors combined with radiotherapy: are we ready?
Authors: Sun Chen , Chu Alan , Song Rui , Liu Shijia , Chai Ting , Wang Xin , Liu Zongwen
Published: October 2023

PARP was an enzyme found in the nucleus of eukaryotic cells that played a crucial role in repairing damaged DNA. Recently, PARP inhibitors have demonstrated great potential in cancer treatment. Thus, the FDA has approved several small-molecule PARP inhibitors for cancer maintenance therapy. The combination of PARP inhibitors and radiotherapy relies on synthetic lethality, taking advantage of the flaws in DNA repair pathways to target cancer cells specifically. Studies conducted prior to clinical trials have suggested that the combination of PARP inhibitors and radiotherapy can enhance the sensitivity of cancer cells to radiation, intensify DNA damage, and trigger cell death. Combining radiotherapy with PARP inhibitors in clinical trials has enhanced the response rate and progression-free survival of diverse cancer patients. The theoretical foundation of PARP inhibitors combined with radiotherapy is explained in detail in this article, and the latest advances in preclinical and clinical research on these inhibitors for tumor radiotherapy are summarized. The problems in the current field are recognized in our research and potential therapeutic applications for tumors are suggested. Nevertheless, certain obstacles need to be tackled when implementing PARP inhibitors and radiotherapies in clinical settings. Factors to consider when using the combination therapy are the most suitable schedule and amount of medication, identifying advantageous candidates, and the probable adverse effects linked with the combination. The combination of radiotherapy and PARP inhibitors can greatly enhance the effectiveness of cancer treatment.
Case report: Clinical management of recurrent small cell lung cancer transformation complicated with lung cancer-induced acute pancreatitis after lung adenocarcinoma surgery
Authors: Zhang Suyun , Guo Ningjing , Zhang Qianyuan , Wang Yao , Yang Sheng , Chen Xiangqi
Published: October 2023

In the diagnosis and treatment of non-small cell lung cancer (NSCLC), the histological type may change from lung adenocarcinoma to lung squamous cell cancer or small cell lung cancer (SCLC). Pancreatic metastasis is extremely rare in advanced lung cancer, and pancreatitis characterized by lung cancer metastasis-induced acute pancreatitis (MIAP) is more rare. This paper reports in detail the clinical diagnosis and treatment of a female patient with lung adenocarcinoma who relapsed after radical surgery and progressed after multiple treatments. A second pathological biopsy revealed SCLC transformation, and the patient developed pancreatic metastasis and lung cancer MIAP during follow-up treatment. This paper mainly suggests that clinicians should pay attention to the possibility of pathological type transformation in the progression of advanced NSCLC, closely observe the dynamic changes of tumor markers and pay attention to the re-biopsy pathological analysis. In addition, it provides clinical experience and scientific reference for the discovery, diagnosis and treatment of transforming SCLC and lung cancer MIAP.
Antinociceptive effect of Nephelium lappaceum L. fruit peel and the participation of nitric oxide, opioid receptors, and ATP-sensitive potassium channels
Authors: Oliveira Alan Santos , Biano Laiza Santos , Palmeira David Nascimento , Almeida Damião Rabelo de , Lopes-Ferreira Mônica , Kohlhoff Markus , Sousa Jordano Augusto Carvalho , Brandão Geraldo Célio , Silva Ana Mara de Oliveira e , Grespan Renata , Camargo Enilton Aparecido
Published: October 2023

Introduction:Nephelium lappaceum L. (Sapindaceae) is a plant known as rambutan. It is used for various purposes in traditional medicine.

Objective: We aimed to evaluate the antinociceptive effects of the ethanol extract of the fruit peel of N. lappaceum (EENL), the mechanisms involved in these effects, and the acute toxicity in zebrafish.

Methods: We performed chromatography coupled to mass spectrometry, acute toxicity assay in zebrafish, and evaluation in mice submitted to models of nociception and locomotor activity.

Results: We identified (epi)-catechin, procyanidin B, and ellagic acid and its derivatives in EENL. We did not find any toxicity in zebrafish embryos incubated with EENL. The locomotor activity of mice submitted to oral pretreatment with EENL was not changed, but it reduced the abdominal constrictions induced by acetic acid, the licking/biting time in both the first and second phase of formalin testing and capsaicin testing, and carrageenan-induced paw mechanical allodynia. Oral pretreatment with EENL increased latency time in the hot plate test. This antinociceptive effect was significantly reversed by naloxone, L-arginine, and glibenclamide respectively showing the participation of opioid receptors, nitric oxide, and KATP channels as mediators of EENL-induced antinociception.

Conclusion: EENL causes antinociception with the participation of opioid receptors, nitric oxide, and KATP channels, and is not toxic to zebrafish.
Acoustoelectric brain imaging with different conductivities and acoustic distributions
Authors: Zhou Yijie , Song Xizi , Song Yibo , Guo Jiande , Han Gangnan , Liu Xiuyun , He Feng , Ming Dong
Published: October 2023

Objective: Acoustoelectric brain imaging (AEBI) is a promising imaging method for mapping brain biological current densities with high spatiotemporal resolution. Currently, it is still challenging to achieve human AEBI with an unclear acoustoelectric (AE) signal response of medium characteristics, particularly in conductivity and acoustic distribution. This study introduces different conductivities and acoustic distributions into the AEBI experiment, and clarifies the response interaction between medium characteristics and AEBI performance to address these key challenges.

Approach: AEBI with different conductivities is explored by the imaging experiment, potential measurement, and simulation on a pig’s fat, muscle, and brain tissue. AEBI with different acoustic distributions is evaluated on the imaging experiment and acoustic field measurement through a deep and surface transmitting model built on a human skullcap and pig brain tissue.

Main results: The results show that conductivity is not only inversely proportional to the AE signal amplitude but also leads to a higher AEBI spatial resolution as it increases. In addition, the current source and sulcus can be located simultaneously with a strong AE signal intensity. The transcranial focal zone enlargement, pressure attenuation in the deep-transmitting model, and ultrasound echo enhancement in the surface-transmitting model cause a reduced spatial resolution, FFT-SNR, and timing correlation of AEBI. Under the comprehensive effect of conductivity and acoustics, AEBI with skull finally shows reduced imaging performance for both models compared with no-skull AEBI. On the contrary, the AE signal amplitude decreases in the deep-transmitting model and increases in the surface-transmitting model.

Significance: This study reveals the response interaction between medium characteristics and AEBI performance, and makes an essential step toward developing AEBI as a practical neuroimaging technique.
Uncovering paradoxes of compassion at work: a dyadic study of compassionate leader behavior
Authors: Krause Vinzenz , Rousset Célia , Schäfer Björn
Published: October 2023

In today’s business world, organizations tend to overlook that employees face suffering caused by work and non-work-related events that can negatively impact business organizations in the long run. One way to address this challenge is through leadership acknowledging and alleviating employees’ suffering to ensure a company’s success. However, research on compassion and leadership in business settings is still relatively scarce. In this study, we aim to extend the organizational compassion literature by addressing our research question: “What are paradoxes induced by compassionate leader behavior in the workplace in the context of social hierarchy?”. We conducted a qualitative exploratory study based on 12 semi-structured interviews with six dyads of leaders and their direct subordinates from small, medium, and large firms representing different industries. The findings of our study indicate that compassionate leader behavior goes hand-in-hand with paradoxical situations that both leader and member face in the workplace, supporting the proposition that compassion as a social, interpersonal process is complex and multi-faceted. Our analysis identified 6 compassion paradoxes that spring from compassion from a leader towards a member. Our study differentiates from other research of compassion paradoxes in the sense that it also focuses on the interplay between leader and member. From that perspective, the findings of our study indicate that social hierarchy is playing a crucial role and exacerbating some paradoxical tensions. This consideration implies that to be effective, compassionate leaders need to have or develop the ability to continuously transcend those compassion paradoxes, as well as support their members in transcending the paradoxes they find themselves dealing with. Thus, the findings of our study contribute to management literature in the field of Positive Organizational Scholarship (POS) by highlighting compassion as a critical element of dyadic leader-subordinate relationships that could be reinforced by systematically building more competence in leaders and members to navigate the tensions emerging from the identified compassion paradoxes. Additionally, we provide limitations and recommendations for further research, along with several theoretical and practical implications of the results, which are particularly relevant for practitioners such as managing directors, leaders, employees, human resource managers, academics, and business and HR consultants.
Family function, anxiety and depression in adults with disabilities: a network analysis
Authors: Wang Bin , Yuan Dongling , Zhong Xiao , Yang Fan , Fu Haojie
Published: October 2023

Background

The prevalence of family dysfunction, anxiety and depression is high in people with disabilities due to long-term activity constraints and social difficulties. Recently, although studies have attempted to provide guidance for family therapy by focusing on the relationship between family function and negative emotions, the specific effects of improved family function during family therapy on alleviation of anxiety and depressive symptoms have been obscured. Thus, this study attempted to elucidate the impact of specific family functioning on specific symptoms of anxiety and depression through network analysis.

Methods

Family APGAR Index Questionnaire (APGAR), Generalized Anxiety Scale (GAD-7), and Patient Health Questionnaire Depression Scale (PHQ-9) were used to survey 897 adults with disabilities in Sichuan Province. Meanwhile, network analysis for studying the relationship between anxiety, depression and family functioning among the disabled via R software.

Results

The network analysis showed that (1) Nodes PHQ4 (“Energy”), APGAR3 (“Growth”), GAD1 (“Nervousness”) and GAD4 (“Relaxing Trouble”) were central nodes in the network model; (2) Bridge nodes linking family function, anxiety and depressive symptoms in the sample were PHQ9 (“Suicide ideation”), PHQ6 (“Worthlessness”), GAD1 (“Nervousness”) and GAD5 (“Restlessness”); (3) The node APGAR5 (“Resolve”) directly connects the bridge symptoms PHQ9 (“Suicide ideation”) and PHQ8 (“Motor”).

Conclusion

This study suggests that therapists could target the resolve of family members during family therapy to reduce suicidal ideation and enhance the level of activity of people with disabilities, thereby improving the network of anxiety and depression symptoms and alleviating negative emotions of people with disabilities.
The relationship between self-control and mental health problems among Chinese university students
Authors: He Mu , Zhan Xiaoqing , Liu Chang , Li Ling , Zhao Xiaojie , Ren Lei , Li Kuiliang , Luo Xi
Published: October 2023

Background

Mental health issues are often associated with poor self-control. Therefore, effective interventions against mental health problems should include self-control training. However, it is unclear whether the effect of self-control varies across different types of mental health problems.

Methods

A cross-sectional survey was conducted using the convenience sampling method at five universities in Chongqing, China, where 1,409 students reported their demographic information, level of self-control, and symptoms of irritability, depression, and anxiety. Descriptive statistical methods and a network analysis approach were employed to explore the relationship between self-control and symptoms of irritability, depression, and anxiety among 1,409 students. The bridging links between self-control and the three mental health problems were analyzed.

Results

The findings revealed a negative correlation between self-control and symptoms of irritability, depression, and anxiety among university students. Impulse control was found to be the bridge between self-control and irritability or anxiety symptoms, while resistance to temptation was the bridge between self-control and depressive symptoms.

Conclusion

These results demonstrate the different relationship between self-control with irritability, anxiety, and depressive symptoms. The findings of this study may shed light on future mental health interventions for university students during potential public health emergencies, such as prior knowledge of the main types of psychological problems among university students, which may allow for the development of precise self-control intervention strategies, such as targeting impulsivity or resistance to temptation.
Peer-led BASICS intervention to reduce alcohol consumption and alcohol-related consequences among university students: a randomized controlled trial
Authors: Lavilla-Gracia María , Pueyo-Garrigues María , Calavia Gil Diego , Esandi-Larramendi Nuria , Alfaro-Diaz Cristina , Canga-Armayor Navidad
Published: October 2023

Introduction

Alcohol consumption is the main substance abused during university and is associated with physical, legal, emotional, social, and cognitive consequences. The peer-led BASICS intervention has been shown to be effective in decreasing the quantity and frequency of drinking, the estimated peak blood alcohol concentration (BAC), and the number of binge drinking episodes among this population.

Objective

This study evaluated the effectiveness of the peer-led BASICS intervention to reduce risky alcohol consumption among university students in the Spanish context.

Materials and methods

A two-arm randomized controlled trial in a university in northern Spain including 308 first- and second-year university students recruited between October 2022 to March 2023. The intervention was a 30-min in-person peer-led motivational interview. Participants were assessed at baseline and 1-month postintervention. The primary outcome was the quantity and frequency of alcohol consumption during a typical week. The intervention effect was verified using a mixed factorial ANOVA model.

Results

Compared with students in the control group, students who received the intervention reduced the number of drinks per week by 5.7 (95% CI 5.54, 5.86); the number of drinks consumed in a typical weekend by 5.2 (95% CI 5.07, 5.33); the number of drinks consumed on the occasion of greatest consumption by 4.9 (95% CI 4.78, 5.02); the number of binge drinking episodes by 1.4 (95% CI 1.37, 1.43); the peak BAC on a typical week and on the occasion of greatest consumption decreased by 0.06 (95% CI 0.058, 0.062) and 0.09 (95% CI 0.088, 0.092); the number of alcohol-related consequences by 5.8 (95% CI 5.67, 5.93); and the motivation to change their alcohol use increased by −0.8 (95% CI −0.85, −0.75).

Conclusion

The peer-led BASICS intervention is effective in changing alcohol consumption and its related consequences among Spanish university students in the short term. The action of nursing students as counselors positively impacted drinking patterns among their peers.

Clinical trial registration

https://clinicaltrials.gov/study/NCT05639374?intr=Effectiveness%20of%20a%20Peer-led%20Program%20to%20Prevent%20Alcohol%20Consumption&rank=1&page=1&limit=10, identifier: NCT05639374.
Role of computed tomography in the evaluation of regional metastasis in well-differentiated thyroid cancer
Authors: Vaish Richa , Mahajan Abhishek , Sable Nilesh , Dusane Rohit , Deshmukh Anuja , Bal Munita , D’cruz Anil K.
Published: October 2023

Background

Accurate neck staging is essential for performing appropriate surgery and avoiding undue morbidity in thyroid cancer. The modality of choice for evaluation is ultrasonography (US), which has limitations, particularly in the central compartment, that can be overcome by adding a computed tomography (CT).

Methods

A total of 314 nodal levels were analyzed in 43 patients with CT, and US; evaluations were done between January 2013 and November 2015. The images were reviewed by two radiologists independently who were blinded to histopathological outcomes. The sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV), and accuracy of US, CT, and US + CT were calculated using histology as the gold standard.

Results

The overall sensitivity, specificity, PPV, and NPV for US, CT, and US + CT were 53.9%, 88.8%, 74.1%, and 76.4%; 81.2%, 68.0%, 60.1%, and 85.9%; and 84.6%, 66.0%, 59.6%, and 87.8%, respectively. The overall accuracy of the US was 75.80%, the CT scan was 72.93%, and the US + CT scan was 72.93%. For the lateral compartment, the sensitivity, specificity, PPV, and NPV for the US, CT, and US + CT were 56.6%, 91.4%, 77.1%, and 80.5%; 80.7%, 70.6%, 58.3%, and 87.8%; and 84.3%, 68.7%, 57.9%, and 89.6%, respectively. The accuracy of the US was 79.67%, the CT scan was 73.98%, and the US + CT scan was 73.98% for the lateral compartment. For the central compartment, the sensitivity, specificity, PPV, and NPV for the US, CT, and US + CT were 47.1%, 76.5%, 66.7%, and 59.1%; 82.4%, 55.9%, 65.1%, and 76.0%; and 85.3%, 52.9%, 64.4%, and 78.3%, respectively. The accuracy of the US was 61.76%, the CT scan was 69.12%, and the US + CT scan was 69.12% for the central compartment.

Conclusions

This study demonstrated that CT has higher sensitivity in detecting nodal metastasis; however, its role is complementary to US due to low specificity.
Finding Bottlenecks in Message Passing Interface Programs by Scalable Critical Path Analysis
Authors: Korkhov Vladimir , Gankevich Ivan , Gavrikov Anton , Mingazova Maria , Petriakov Ivan , Tereshchenko Dmitrii , Shatalin Artem , Slobodskoy Vitaly
Published: October 2023

Bottlenecks and imbalance in parallel programs can significantly affect performance of parallel execution. Finding these bottlenecks is a key issue in performance analysis of MPI programs especially on a large scale. One of the ways to discover bottlenecks is to analyze the critical path of the parallel program: the longest execution path in the program activity graph. There are a number of methods of finding the critical path; however, most of them suffer a performance drop when scaled. In this paper, we analyze several methods of critical path finding based on classical Dijkstra and Delta-stepping algorithms along with the proposed algorithm based on topological sorting. Corresponding algorithms for each approach are presented including additional enhancements for increasing performance. The implementation of the algorithms and resulting performance for several benchmark applications (NAS Parallel Benchmarks, CP2K, OpenFOAM, LAMMPS, and MiniFE) are analyzed and discussed.
Dynamic Demand-Responsive Feeder Bus Network Design for a Short Headway Trunk Line
Authors: Nickkar Amirreza , Lee Young-Jae
Published: October 2023

Recent advancements in technology have increased the potential for demand-responsive feeder transit services to enhance mobility in areas with limited public transit access. For long rail headways, feeder bus network algorithms are straightforward, as the maximum feeder service cycle time is determined by rail headway, and bus–train matching is unnecessary. However, for short rail headways, the algorithm must address both passenger–feeder-bus and feeder-bus–train matching. This study presents a simulated annealing (SA) algorithm for flexible feeder bus routing, accommodating short headway trunk lines and multiple bus relocations for various stations and trains. A 5 min headway rail trunk line example was utilized to test the algorithm. The algorithm effectively managed bus relocations when optimal routes were infeasible at specific stations. Additionally, the algorithm minimized total costs, accounting for vehicle operating expenses and passenger in-vehicle travel time costs, while considering multiple vehicle relocations.
Reactive Flow Dynamics of Low-Frequency Instability in a Scramjet Combustor
Authors: Jeong Seung-Min , Han Hyung-Seok , Sung Bu-Kyeng , Kim Wiedae , Choi Jeong-Yeol
Published: October 2023

This study numerically investigated the combustion instability and characteristics of a laboratory-scale gaseous hydrogen-fueled scramjet combustor. For this purpose, a numerical simulation with an improved detached eddy simulation and a detailed hydrogen/oxygen reaction mechanism was performed. The numerical framework used high-resolution schemes with high-order accuracy to ensure high resolution and fidelity. A total of five fuel injection pressures were considered to characterize the combustion instability as a function of the equivalence ratio. A sampling time of up to 100 ms was considered to sufficiently accumulate several cycles of low-frequency combustion instability dynamics with a period in the order of 100 Hz. Numerical results revealed the repetitive formation/dissipation dynamics of the upstream-traveling shock wave, and it acts as a key factor of combustion instability. The period and derived principal frequency of these upstream-traveling shock waves is several ms. The frequency analysis showed that the instability frequency increased in the low-frequency range as the combustion mode transitioned from the cavity shear-layer to the jet-wake type. This characteristic was derived from the transition in combustion mode at the same equivalence ratio. Therefore, it suggests that the instability frequency shifting is governed by the combustion mode rather than the equivalence ratio. These comprehensive numerical results demonstrated not only the effect of the equivalence ratio but also the important role of the combustion mode on the low-frequency combustion instability.
Assessing Flight Crew Fatigue under Extra Augmented Crew Schedule Using a Multimodality Approach
Authors: Li Yan , He Jibo , Cao Shi , Zheng Jiajie , Dou Yazhou , Liu Chenxi , Liu Xufeng
Published: October 2023

During the COVID-19 pandemic, the question of how to reduce the risk of viral infection for international airline pilots without increasing the risk of fatigue was a novel and urgent theoretical and practical problem, which had never been encountered in the world civil aviation industry. A new scheduling method implemented by the Civil Aviation Administration of China (CAAC) is the extra augmented crew (EAC) schedule, which avoids crew layover in another country on international flights by extending the maximum duty time and adding two additional crew members to such long-haul flights. In this study, a multi-day flight crew fatigue assessment was conducted to evaluate the impact of EAC flight. We recruited 71 pilots as participants, and their fatigue during EAC flights was measured using a multimodality approach integrating a subjective fatigue report, a psychomotor vigilance task, sleep monitoring, and biomathematical model predictions. The results showed that the subjective fatigue level increased during duty time compared to off-duty time, but still with acceptable levels of under 7, as measured by the Karolinska Sleepiness Scale; objective secondary task performance, as measured by the classic psychomotor vigilance task, showed no differences; pilots were able to get around 6 h of sleep, although they slept less during duty time compared to off-duty time. Model fitting using the FAID biomathematical model of fatigue confirmed that the EAC scheduling was compliant with the FAID tolerance level 91.3% of the time. The results suggest that the EAC flight created some moderate level of increased fatigue but no severe fatigue to cross-continent long-haul flight crews. This research can inform current and future scheduling and fatigue risk control during the pandemic or for future time-sensitive periods.
Different Response of Carbon and P-Related Soil Properties toward Microbial Fertilizer Application
Authors: Długosz Jacek , Piotrowska-Długosz Anna
Published: October 2023

While some studies regarding the effect of biofertilizers on plants, including their yield and quality, less is known about how they affect the soil properties, especially the microbial and enzymatic properties. Biofertilizers are promising for enhancing the nutrient availability in agricultural soils and reducing the reliance on inorganic fertilizers. The aim of this four-year-long field experiment was to assess the influence of the use of UGmax biofertilizer, which contains bacterial strains enhancing the soil phosphorus availability, e.g., the Pseudomonas spp. strains from Azotobacter and Penicillium genera, on the soil P forms and acid and alkaline phosphatase activity (AcP, AlP) in the surface soil horizon (Ap). Winter wheat was cultivated in 2005, 2006, and 2008, while winter rapeseed was cultivated in 2007 in a research area (2 hectare) that was selected for the investigation. These plants were selected because they are the main agricultural crops in Poland. UGmax was applied in three successive years after the plants had been harvested. One dose of the biofertilizer (0.7 L per hectare) was applied after the harvesting of wheat had been harvested (2005–2007), while the second dose (0.3 L per hectare) was applied as a top dressing in the spring, when the plants were beginning to grow (2006–2008). Forty soil samples were taken in 2005 (the control year without the application of UGmax). In the following years (2006–2008), 20 soil samples were taken from the area after the UGmax had been applied in the previous year, as well as 20 soil samples from the control area. A grid soil sampling technique (40 m × 25 m) was used to assess the changes in the soil properties across both of the studied areas. The soil samples were taken from the surface (Ap) horizon. Only at the end of the experiment (2008) did the application of UGmax remarkably increase the organic carbon (Corg) and total nitrogen (Nt) content, while the microbial biomass carbon (MBC) content was notably higher in the field with UGmax than in the control. The available P content (Pavail) was significantly higher in the field with UGmax compared to these without the biofertilizer in 2006 and 2008, while no considerable relation was noted for the total phosphorus (Ptot) and water soluble P (Pwater) content in any of the study years. Over the entire period of the experiment, the AcP and AlP were notably lower in the soil samples that were collected from the UGmax field compared to that of the control soil. It was concluded that the application of UGmax exhibited a phosphate-solubilizing activity that could be an encouraging attitude for increasing P bioavailability in arable fields and that further studies ought to be carried out under different soil and climatic conditions in order to confirm such a phenomenon.
Effect of Micronutrients and L-Carnitine as Antioxidant on Sperm Parameters, Genome Integrity, and ICSI Outcomes: Randomized, Double-Blind, and Placebo-Controlled Clinical Trial
Authors: Lahimer Marwa , Gherissi Oumaima , Ben Salem Nesrine , Ben Mustapha Henda , Bach Véronique , Khorsi-Cauet Hafida , Khairi Hedi , Ben Ali Habib , BenKhalifa Moncef , Ajina Mounir
Published: October 2023

The evaluation of sperm DNA integrity is recommended in the sixth edition of the 2021 World Health Organization guidelines. Oxidative stress has been identified as a crucial factor leading to genome decay, lipid peroxidation, and nucleoprotein oxidation. This double-blind, placebo-controlled clinical trial aimed to assess the effect of oral antioxidant treatment (Fertilis), which contains L-carnitine and some micronutrients, in the improvement of conventional sperm parameters, sperm DNA integrity and in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes. A total of 263 participants were enrolled and randomly divided into two groups: 131 participants received the antioxidant treatment, while 132 participants received a placebo. The male partners in both groups underwent the antioxidant treatment or the placebo for a duration of three months. For each participant, we performed a hormonal test, an infectious test, a spermogram, a TUNEL assay for sperm DNA fragmentation, a toluidine blue staining for sperm DNA decondensation, and an IVF/ICSI procedure. Sperm characteristics analysis (volume, count, motility, and vitality), sperm DNA fragmentation, and sperm DNA decondensation were assessed and compared to the results preceding the antioxidant treatment. The study outcome revealed a significant decrease in the DNA fragmentation index and a significant increase in sperm motility after 3 months of treatment (p = 0.01 and p = 0.02, respectively). Additionally, a significant improvement in clinical pregnancy rate (p = 0.01) and life birth rate (p = 0.031) was observed. No significant changes were observed in conventional sperm parameters (volume, count, and vitality) or sperm DNA decondensation (SDI). Antioxidant therapy has a beneficial impact on achieving pregnancy, whether through spontaneous conception or assisted reproductive procedures (ART).
Targeting Pro-Oxidant Iron with Exogenously Administered Apotransferrin Provides Benefits Associated with Changes in Crucial Cellular Iron Gate Protein TfR in a Model of Intracerebral Hemorrhagic Stroke in Mice
Authors: García-Serran Alexia , Ordoño Jesús , DeGregorio-Rocasolano Núria , Melià-Sorolla Marc , Odendaal Karla , Martí-Sistac Octavi , Gasull Teresa
Published: October 2023

We have previously demonstrated that the post-stroke administration of iron-free transferrin (apotransferrin, ATf) is beneficial in different models of ischemic stroke (IS) through the inhibition of the neuronal uptake of pro-oxidant iron. In the present study, we asked whether ATf is safe and also beneficial when given after the induction of intracerebral hemorrhage (ICH) in mice, and investigated the underlying mechanisms. We first compared the main iron actors in the brain of IS- or collagenase-induced ICH mice and then obtained insight into these iron-related proteins in ICH 72 h after the administration of ATf. The infarct size of the IS mice was double that of hemorrhage in ICH mice, but both groups showed similar body weight loss, edema, and increased ferritin and transferrin levels in the ipsilateral brain hemisphere. Although the administration of human ATf (hATf) to ICH mice did not alter the hemorrhage volume or levels of the classical ferroptosis GPX4/system xc- pathways, hATf induced better neurobehavioral performance, decreased 4-hydroxynonenal levels and those of the second-generation ferroptosis marker transferrin receptor (TfR), and restored the mRNA levels of the recently recognized cytosolic iron chaperone poly(RC) binding protein 2. In addition, hATf treatment lowered the ICH-induced increase in both endogenous mouse transferrin mRNA levels and the activation of caspase-2. In conclusion, hATf treatment provides neurobehavioral benefits post-ICH associated with the modulation of iron/oxidative players.