bluuebunny/crossref_metadata_2025 huggingface dataset:
Ḳus B. Sâʿide’nin Meşhur Hutbesi Bağlamında: Hutbelerin Arap Dili Öğreniminde Kullanımı Üzerine
Authors: ARSLAN Kıyasettin
Published: September 2022

İnsanlar, tarihin ilk dönemlerinden itibaren farklı kültür ve medeniyetleri tanımak, ya da kendi kültür ve medeniyetini tanıtmak için başkalarıyla iletişime geçme gereği duymuşlardır. Başkalarıyla iletişim ihtiyacı, dil öğrenimi esnasında elde edilen, konuşma, okuma ve yazma gibi dil becerilerinin gelişmesi ile sağlanabilir. Dil öğrenimi gereksinimini gidermek için, direkt, doğal, işitsel-dilsel, bilişsel…vb. birçok yöntem geliştirilmiştir. Bu yöntemlerden biri de dilbilgisi-çeviri yöntemidir. Dil öğreniminde dilbilgisi-çeviri yöntemini benimseyenler, öğretmek istedikleri hedef dilden metinler seçerek öğrencilerinin dil becerilerinin gelişmesine çalışmaktadırlar. Bu çalışmada hutbeler, Ḳus b. Sâide’nin meşhur hutbesi bağlamında ele alınmaktadır. İçerdikleri zengin dil malzemesi nedeniyle de dilbilgisi-çeviri yöntemi için en uygun metinler olmaları gerektiği konu edinilmektedir. Belirtilen konu üzerinden hutbelerin, zengin Arap dili malzemesi içerdiklerini ve Arap dili öğreniminde dilbilgisi-çeviri yöntemini kullananlar için metin seçiminin hutbelerden de yapılabileceğini vurgulamayı amaçlamaktadır. Söz konusu çalışma, giriş ve iki başlığı kapsamakta olup, girişte hutbelerin zengin dil malzemesi içeren seçkin metinler olduğu tartışılmıştır. Bu bağlamda ülkemizde hutbe ve hatip kavramları üzerinden literatür çalışması yapılarak bazı çalışmaların analizlerine yer verilmiştir. Ḳus b. Sâide’nin biyografisi ve onun Hz. Muhammed’le olan bağlantısına değinilerek söz konusu hutbenin metni makaleye alınıp Türkçeye çevrilmiştir. Hutbenin içerdiği dil malzemesi tespit edilerek belagat unsurları ve gramer çeşitliliği şeklinde tasnif edilmiştir. Hutbeden random yöntemi ile sarf ilmi, nahiv ilmi ve belagate dair örnek ifadeler seçilmiştir. Seçilen örnek ifadeler üzerinden hutbelerin, Arap dili öğreniminde dilbilgisi-çeviri yöntemi açısından nasıl kullanılacağı tartışılmıştır. Bu makalede konu ve kapsam çerçevesine alınan tartışmalar betimleme yöntemi ile sunulmuştur. Söz konusu örnek hutbe üzerinden yapılan analizlere göre hutbelerin belagat ve gramer unsurları açısından oldukça zengin olduğu görülmüştür. Dil öğreniminde dilbilgisi-çeviri yöntemi kullanan öğreticilerin, örnek metinlerini hutbelerden seçmelerinin doğru bir seçim olacağı sonucuna ulaşılmıştır.
Analysis of junior high school mathematics reasoning ability from multiple intelligence in hybrid learning
Authors: Zamani Wildan Azhar , Hendriana Benny
Published: September 2022

Penelitian ini bertujuan untuk mendeskripsikan kemampuan penalaran matematis siswa SMPIT Raudhatul Jannah ditinjau dari multiple intelligence pada pembelajaran hybrid. Penelitian ini menggunakan metode kualitatif deskriptif. Subjek penelitian terdapat 3 siswa dari kelas 9E. Teknik pengumpulan data dengan metode tes soal kemampuan penalaran matematis, metode tes angket multiple intelligence, dan metode wawancara. Teknik analisis data yang digunakan dengan mereduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian yang diperoleh yaitu subjek yang memiliki kecerdasan visual-spatial dan kecerdasan linguistik memenuhi indikator analisis, generalisasi, dan sintesis. Pada indikator justifying dan penyelesaian persoalan non-rutin pada kecerdasan visual-spasial dan kecerdasan linguistik masih belum terpenuhi. Subjek yang memiliki kecerdasan logical-mathematical  memenuhi indikator analisis, generalisasi, sintesis, dan penyelesaian persoalan non–rutin. Pada indikator justifying subjek yang memiliki kecerdasan logical-mathematical  masih belum terpenuhi. Pada pembelajaran hybrid, logical mathematics intelligence lebih baik terhadap kemampuan penalaran matematis dibandingkan linguistic intelligence dan visual spatial intelligence.
The Perception of Belonging and Marginalization Scale of Euro-Turks: Validity and Reliability Study
Authors: YAMAN Fatih
Published: September 2022

The characteristics of social life are established by the perceptions of individuals regarding their position in society. In this respect, belonging or marginalization, which are effective in the construction of identity, are important parameters defining the perception of social positioning. The present study is a scale development study that aimed to uncover the perceptions of Euro-Turks about belonging and marginalization in Germany. The sampling of the study consisted of a total of 608 participants living in Germany, 354 of whom were women, 254 were men, and the mean age was 35.8. As a result of the factor analysis, it was found that the scale that had 11 items consisted of a two-factor structure, belonging and marginalization, and the total variance that was explained was 53.59%. As a result of the Confirmatory Factor Analysis that was made on a different sampling group, it was determined that the model established according to the goodness of fit indices was at a significant and acceptable level. Regarding the criterion validity, General Belongingness Scale and Social Exclusion Scale were applied, and as a result of the analyses, significant relations were found between scale scores. The Cronbach’s Alpha Reliability Coefficient was found to be r= .71 for the belonging sub-dimension of the scale, and r= .76 for the marginalization sub-dimension. The test-retest reliability results were found to be .82 for belonging sub-dimension and .84 for marginalization sub-dimension. Also, all the values of item statistics were significant at the (p
İspanyol Indignados/15M Hareketi Üzerine Bir Değerlendirme
Authors: KONAK İhsan
Published: September 2022

2011 yılında dünya genelinde yoğun protesto hareketleri yaşanmıştır. Bu hareketler sadece gelişmemiş veya az gelişmiş ülkelerle sınırlı kalmamıştır. Ekonomisi gelişmiş, demokrasi düzeyi ve kalitesi görece yüksek ülkelerde de protesto hareketleri yaşanmıştır ve yeni toplumsal hareketlerin oluşumuna tanıklık edilmiştir. Dünyanın farklı yerlerinde yaşadıkları ülkelerin önemli meydanlarını işgal eden öfkeli kalabalıklar hem yaşadıkları sosyo-ekonomik sorunları dile getirmiş hem de ülkelerinin siyasal sistemlerini ve bu dizge içerisindeki demokrasi sorunsalını ortaya koymuşlardır. Çalışmada bu dönem İspanya’da ortaya çıkan Indignados/15M hareketi değerlendirilmektedir. 15 Mayıs 2011’de iktisadi krize ve kemer sıkma siyasalarına karşı öfkelerini ve hoşnutsuzluklarını dile getirmek için İspanyol halkı ve özellikle de gençler meydanlara inmiş ve öfkeli göstericiler ‘Indignados’ ismi ile anılmaya başlanmıştır. Görünüşte hiyerarşik bir yapısı olmayan, yerleşik siyasal parti ve sendikalardan destek almamış bu hareketin eylemlerine ciddi bir katılım sağlanmıştır ve eylem biçimleri diğer Avrupa ülkelerine de yayılmıştır. Bu çalışmada öncelikle hareketin doğuşu ve onu meydana çıkaran koşullar ortaya konulmaktadır. Ardından kamusal alanlar olarak meydan işgallerinin anlamı, hareketin örgütsel yapısı ve İspanyol siyasetine etkisi ele alınmaktadır. Bu çalışmada Indignados/15M hareketi İspanya bağlamında analitik bir incelemeye tabi tutulmaktadır.
İstiklâl Marşı Tartışmalarının Yüz Yılı: Sahiplenilmeyen Milli Ethos ve Ulus İnşası Problemi
Authors: KAYA Vefa Can
Published: September 2022

Milli marşlar milletlerin kimliğini ve karakterini, hedeflerini ve arzularını ortaya koyan ulusal sembollerdir. Sosyolojik açıdan inşa edilmiş nesneler olarak ulusal sembolleri imal eden ve dağıtımını sağlayarak meşruiyet kazanmasını sağlayan toplumsal aktörler ise siyasal seçkinlerdir. Bu çerçevede siyasal seçkinlerin milli marşların inşa edilmesi ve benimsetilmesi sürecinde marşların toplumu bağlayıcı ve birleştirici işlevinden faydalanma istekleri bütün marşlarda ortak özellik olarak karşımıza çıkar. Bir şiirin milli marş olarak kabul edilmesi, benimsenmesi ve tartışılması süreci, inşa edilen ulusal kimliğe ilişkin önemli ipuçları sunar. Bu makalede, İstiklâl Marşı’na ilişkin tartışmaların yüz yıllık seyri Türk siyasi tarihi bağlamında ve ulus inşası problemi çerçevesinde ele alınacaktır. Bu çerçevede tartışmaların seyri takip edildiğinde, resmi ideoloji ile milli marş arasında açılan makasın giderek derinleştiği ve oluşan boşluğun 1970’li yılların politik ortamında genç kuşaklar arasında yayılan radikal ideolojilere eşlik eden alternatif ideolojik marşlar tarafından doldurulduğu görülmektedir. 12 Eylül darbesi ile toplumsal ve siyasal alanda yeni bir ulusal birlik ideolojisi kurmak isteyen siyasal seçkinlerin milli marşı siyasal şiddet aracı olarak kullandıkları ve buna tepki olarak İstiklâl Marşı’nın baskıcı ve otoriter devlet anlayışıyla özdeşleştirildiği bir ortamın oluştuğu ifade edilebilir. Sonuç olarak İstiklâl Marşı tartışmalarının yüz yıllık seyri üzerinden Türkiye’de ulusal kimlik sorununun derinleştiği ortaya konmaktadır.
Migration and Human Mobility in Turkey's Development Plans: An Assessment on the First (1967-1972) and Second (1967-1972) Development Plans
Authors: SAĞIROĞLU Ali Zafer
Published: September 2022

The relationship between migration, mobility and development is one of the topics discussed in social sciences for many years. Over the years, the relationship between the two phenomena has sometimes been evaluated as "optimistic" and sometimes "pessimistically". This study aims to monitor migration and human movements through the development plans prepared within the framework of the planned economic shift that Turkey started in the 1960s. Determining the relationship between the two phenomena is important in terms of understanding the social mobilities that Turkey has experienced in the later periods and today. Tracing migration and human mobility within the development plans prepared in Turkey aimed not only to determine the reactions to the phenomenon of migration but also to clarify how mobility phenomena are viewed in the development initiatives. The concepts of migration and human movements in Turkey's First (1963-1967) and Second (1967-1972) Development Plan reports were analyzed using qualitative methods in this study. As a result of the analysis, four thematic areas were reached; concerns on population growth, increasing internal migration from rural to urban areas, international labour force export as a surplus of labour supply, and the realization of tourism potential.

The attempt to read the migration and human movements in Turkey of the 1960s is meaningful in terms of understanding what has changed and continued over the past 60 years. Among the modernization concerns of the understanding of military tutelage, Turkey's internal migration and demography on the one hand, and the policies it has developed for out-migration on the other hand and the tourist movements that are likely to turn to Turkey are valuable in terms of understanding the current picture of Turkey.
Change in Social Protection Regime for Migrants in Turkey and Its Effects on Labor Markets
Authors: TEMEL Kemal , ACA Zeynep
Published: September 2022

Turkey has been exposed to constant migration flows in the historical process, and Anatolia has been shaped as a migration geography. The civil war in Syria in 2011 became a turning point in migration to Turkey. The Turkish social welfare regime, which mostly covers immigrants from Europe, has been reshaped after the influx of Syrian refugees. This study deals with the impact of the change in the social welfare regime on the migration movements towards Turkey. On the other hand, the effect of opportunity areas in the labor market in Turkey on foreign migration, which has been in a constantly increasing trend after 2011, is evaluated. The welfare regime models to which the countries belong are shown among the main motivations of the migration mobility to that country. In this respect, the access of immigrants to a range of social rights is evaluated according to the welfare regime of immigrant country. In this context, the social protection regime for immigrants is analyzed based on Turkey's welfare regime model. The literature on migration in Turkey mostly tends to deal with Syrian migrants and the problem of mutual integration and exclusion of this group. However, increasing migration movements in recent years put forward labor migration in migration from different geographies to Turkey. In this respect, the reasons of why immigrants prefer Turkey are discussed based on both the scope of the social protection regime and the opportunities in the labor market. While the social protection regime tends to cover mostly Syrians under Temporary Protection, the increased mobility of other migrants to Turkey is largely due to opportunities in the labor market.
Pentingnya Stimulasi Perkembangan Anak oleh Keluarga Balita Melalui Pendampingan Kader
Authors: Damarini Susilo , Andriani Lusi , Wahyuni Elly , Widiyanti Desi , Yulyana Nispi , Sahran Sahran
Published: September 2022

Children under five years old is a member of the family that required special attention from their parents or people close to him and depend on their physically or emotion. The low ability of children is due to the lack of activities that can stimulate motor abilities children in Sukaraja Subdistrict, Seluma Regency, Bengkulu Province, including the stunting locus. The Purpose of this community services is empower cadres in improving skill of family toddlers do stimulation and children development in early detection. Methods: empowerment with cassistance cadres do detection children development. The number of cadres sarimulyo 15 cadres in the village, the number of under fives 140 and BP2 villages is 6 cadres of toddlers 123. Assistance is 3 times, pre-test pos-test and knowledge, cadres assessed children development in each village. Result: knowledge of the cadres in the village sarimulyo increase 61,6 village and BP2 increase 50%, while the result of children under five from the development by cadres BP2 village use KPSP had found 2,4% of the children, doubt children development 4,1%, and 9.3% of the children in accordance with their age. Sarimulyo village had found 3,5% of the children risk of deception, doubt children development 17,8% and development in accordance 78,5% their age. Conclusion: Improvements to the assistance early detection is of great benefit to the toddler to recognize children development.
ABSTRAK
Anak usia bawah lima tahun merupakan anggota keluarga yang memerlukan perhatian khusus dari orang tuanya atau orang yang dekat dengannya dan sangat tergantung baik secara fisik maupun emosi. Rendahnya kemampuan anak disebabkan kurangnya kegiatan yang bisa merangsang motorik anak. Kecamatan Sukaraja Kabupaten Seluma Provinsi Bengkulu termasuk lokus stunting. Tujuan kegiatan pengabdian kepada masyarakat memberdayakan kader dalam meningkatkan kempuan keluarga balita melakukan stimulasi dan deteksi dini perkembangan anak. Metode: pemberdayaan dengan pendampingan kader melakukan deteksi perkembangan balita. Jumlah kader di Desa Sarimulyo 15 kader, jumlah balita 140 dan di desa BP2 ada 6 kader dengan jumlah balita 123. Pendampingan dilakukan 3 kali, pre-tes dan pos-tes pengetahuan, kader melakukan penilaian perkembangan anak di desa masing-masing. Hasil kegiatan menunjukan pengetahuan kader tentang perkembangan di Desa Sarimulyo meningkat 61,6% dan Desa Bukit Peninjauan 2 meningkat 50%, sedangkan hasil dari penilaian perkembangan anak balita oleh kader di Desa BP2 menggunakan KPSP ditemukan anak mengalami penyimpangan 2,4% anak, perkembangan yang meragukan 4,1% anak dan 9.3% anak sesuai dengan usia. Desa Sarimulyo ditemukan 3,5% anak kemungkinan penyimpangan, 17,8% anak perkembangan meragukan dan 78,5% anak perkembangan sesuai umur. Kesimpulan: Pendampingan deteksi dini perkembangan terhadap kader sangat bermanfaat bagi keluarga balita guna mengenali perkembangan anak.
Edukasi Kesehatan pada Ibu Hamil tentang Persiapan Rujukan Persalinan dengan Komplikasi
Authors: Anita Wan , Nafratilova Lita , Agustina Santi , Hayatun Najmi Elsa , Elna Julia
Published: September 2022

The birth planning program and the prevention of childbirth complications are programmed by the government, as one of the efforts to reduce maternal and infant mortality rates due to the high number of complications, especially in childbirth. This requires careful preparation that can be done by the mother and family such as preparing blood donors and so on. This community service aims to provide knowledge to pregnant women about preparing for delivery referrals when they encounter cases of childbirth complications. This community service method is carried out with lectures and discussions. The results of the activity were the results of filling out the pre-test questionnaire, where 83.7% of participants with less knowledge and 8.3% with high knowledge. The results of observations after the post test showed an increase in participants' knowledge to a high of 91.7%. The conclusion is that the education about preparation for referral for delivery with complications can be understood by the participants. It is hoped that pregnant women and their families can prepare for delivery as early as possible so that if cases of complications are found, they can be immediately referred to the referrals that have been prepared.
ABSTRAK
Program Perencanaan persalinan dan pencegahan komplikasi persalinan yang diprogramkan oleh pemerintah, sebagai salah satu upaya penurunan angka kematian ibu dan bayi dikarenakan masih tingginya kasus komplikasi terutama pada persalinan. Hal ini membutuhkan persiapan yang matang yang dapat dilakukan oleh ibu dan keluarga seperti persiapan pendonor darah dan sebagainya. Pengabdian masyarakat ini bertujuan untuk memberikan pengetahuan kepada ibu hamil tentang persiapan rujukan persalinan apabila menemui kasus komplikasi persalinan. Metode pengabdian masyarakat ini dilakukan dengan ceramah dan diskusi. Hasil kegiatan hasil dari pengisian kuisioner pre test, dimana 83,7% peserta dengan pengetahuan kurang dan 8,3% dengan pengetahuan tinggi. Hasil pengamatan setelah dilakukan post test terjadi peningkatan pengetahuan peserta menjadi tinggi sejumlah 91,7%. Kesimpulannya bahwa penyuluhan tentang persiapan rujukan persalinan dengan komplikasi dapat dimengerti oleh peserta. Diharapkan ibu hamil dan keluarga dapat mempersiapkan persalinan sedini mungkin sehingga apabila kasus komplikasi ditemukan dapat segera dirujuk dengan rujukan yang telah dipersiapkan.
Nanomaterials for biogas augmentation towards renewable and sustainable energy production: A critical review
Authors: Khan Sohaib Z. , Zaidi Asad A. , Naseer Muhammad Nihal , AlMohamadi Hamad
Published: September 2022

Nanotechnology is considered one of the most significant advancements in science and technology over the last few decades. However, the contemporary use of nanomaterials in bioenergy production is very deficient. This study evaluates the application of nanomaterials for biogas production from different kinds of waste. A state-of-the-art comprehensive review is carried out to elaborate on the deployment of different categories of nano-additives (metal oxides, zero-valent metals, various compounds, carbon-based nanomaterials, nano-composites, and nano-ash) in several kinds of biodegradable waste, including cattle manure, wastewater sludge, municipal solid waste, lake sediments, and sanitary landfills. This study discusses the pros and cons of nano-additives on biogas production from the anaerobic digestion process. Several all-inclusive tables are presented to appraise the literature on different nanomaterials used for biogas production from biomass. Future perspectives to increase biogas production via nano-additives are presented, and the conclusion is drawn on the productivity of biogas based on various nanomaterials. A qualitative review of relevant literature published in the last 50 years is conducted using the bibliometric technique for the first time in literature. About 14,000 research articles are included in this analysis, indexed on the Web of Science. The analysis revealed that the last decade (2010–20) was the golden era for biogas literature, as 84.4% of total publications were published in this timeline. Moreover, it was observed that nanomaterials had revolutionized the field of anaerobic digestion, methane production, and waste activated sludge; and are currently the central pivot of the research community. The toxicity of nanomaterials adversely affects anaerobic bacteria; therefore, using bioactive nanomaterials is emerging as the best alternative. Conducting optimization studies by varying substrate and nanomaterials’ size, concentration and shape is still a field. Furthermore, collecting and disposing nanomaterials at the end of the anaerobic process is a critical environmental challenge to technology implementation that needs to be addressed before the nanomaterials assisted anaerobic process could pave its path to the large-scale industrial sector.
Evaluation of antibacterial property and biocompatibility of Cu doped TiO2 coated implant prepared by micro-arc oxidation
Authors: kang Binbin , Lan Dongmei , Yao Chao , Liu Ping , Chen Xiaohong , Qi Shengcai
Published: September 2022

In order to enhance osteogenic differentiation and antibacterial property of dental implants, volcano-shaped microporous TiO2 coatings doped with Cu were fabricated via micro-arc oxidation (MAO) on Ti. Cu-doped coating with different mass ratios of Cu were obtained by changing the concentration of copper acetate in the electrolyte. The structure of Cu-TiO2 coatings were systematically investigated. Element Copper was uniformly distributed throughout the coating. Compared with TiO2 coating, the Cu-doped can further improved proliferation of bone mesenchymal stem cells (BMSCs), facilitated osteogenic differentiation. The bacteriostasis experiments demonstrated that Cu-doped TiO2 coating possess excellent antibacterial property against Staphylococcus aureus (S. aureus) and Porphyromonas gingivalis (P. gingivalis).
Machine-learned-based prediction of lower extremity overuse injuries using pressure plates
Authors: Nuyts Loren , De Brabandere Arne , Van Rossom Sam , Davis Jesse , Vanwanseele Benedicte
Published: September 2022

Although running has many benefits for both the physical and mental health, it also involves the risk of injuries which results in negative physical, psychological and economical consequences. Those injuries are often linked to specific running biomechanical parameters such as the pressure pattern of the foot while running, and they could potentially be indicative for future injuries. Previous studies focus solely on some specific type of running injury and are often only applicable to a gender or running-experience specific population. The purpose of this study is, for both male and female, first-year students, (i) to predict the development of a lower extremity overuse injury in the next 6 months based on foot pressure measurements from a pressure plate and (ii) to identify the predictive loading features. For the first objective, we developed a machine learning pipeline that analyzes foot pressure measurements and predicts whether a lower extremity overuse injury is likely to occur with an AUC of 0.639 and a Brier score of 0.201. For the second objective, we found that the higher pressures exerted on the forefoot are the most predictive for lower extremity overuse injuries and that foot areas from both the lateral and the medial side are needed. Furthermore, there are two kinds of predictive features: the angle of the FFT coefficients and the coefficients of the autoregressive AR process. However, these features are not interpretable in terms of the running biomechanics, limiting its practical use for injury prevention.
Controllable self-assembly of thiophene-based π-conjugated molecule and further construction of pillar[5]arene-based host-guest white-light emission system
Authors: Zhong Haibo , Li Liang , Zhu Shajun , Wang Yang
Published: September 2022

Photoluminescence materials have been widely applied in biological imaging and sensing, anti-counterfeiting, light-emitting diodes, logic gates et al. The fabrication of luminescent materials with adjustable emission color by self-assembly of π-conjugated molecules has attracted particular attention. In this study, we designed and synthesized a thiophene-based α-cyanostyrene-derivative (TPPA), then investigate its self-assembly morphology and fluorescence emission under different organic solvents, different proportions of H2O/THF (DMSO) mixture and different pH conditions by UV, FL and SEM images. It was found that TPPA formed nanoparticles by self-assembly in organic solvent (THF or DMSO), accompanied by strong fluorescence emission. However, with the increase of water ratio, the fluorescence intensity decreased accompany with red shift, and the self-assembly morphology changed from nanoparticles to fibers. More interestingly, when pillar[5]arene (P5) was added to form host-guest complex with TPPA, white light emission could be successfully constructed when the ratio of TPPA to P5 was 1:20 and THF to water was 19:1.
Lateral annular systolic excursion ratio: A novel measurement of right ventricular systolic function by two-dimensional echocardiography
Authors: Stock Jonathan D. , Rothstein Eric S. , Friedman Scott E. , Gemignani Anthony S. , Costa Salvatore P. , Milbridge Andrew J. , Zhang Rui , Taub Cynthia C. , O'Rourke Daniel J. , Palac Robert T.
Published: September 2022

Introduction

Accurate assessment of right ventricular (RV) systolic function has prognostic and therapeutic implications in many disease states. Echocardiography remains the most frequently deployed imaging modality for this purpose, but estimation of RV systolic function remains challenging. The purpose of this study was to evaluate the diagnostic performance of a novel measurement of RV systolic function called lateral annular systolic excursion ratio (LASER), which is the fractional shortening of the lateral tricuspid annulus to apex distance, compared to right ventricular ejection fraction (RVEF) derived by cardiac magnetic resonance imaging (CMR).

Methods

A retrospective cohort of 78 consecutive patients who underwent clinically indicated CMR and transthoracic echocardiography within 30 days were identified from a database. Parameters of RV function measured included: tricuspid annular plane systolic excursion (TAPSE) by M-mode, tissue Doppler S', fractional area change (FAC) and LASER. These measurements were compared to RVEF derived by CMR using Pearson's correlation coefficients and receiver operating characteristic curves.

Results

LASER was measurable in 75 (96%) of patients within the cohort. Right ventricular systolic dysfunction, by CMR measurement, was present in 37% (n = 29) of the population. LASER has moderate positive correlation with RVEF (r = 0.54) which was similar to FAC (r = 0.56), S' (r = 0.49) and TAPSE (r = 0.37). Receiver operating characteristic curves demonstrated that LASER (AUC = 0.865) outperformed fractional area change (AUC = 0.767), tissue Doppler S' (AUC = 0.744) and TAPSE (AUC = 0.645). A cohort derived dichotomous cutoff of 0.2 for LASER was shown to provide optimal diagnostic characteristics (sensitivity of 75%, specificity of 87% and accuracy of 83%) for identifying abnormal RV function. LASER had the highest sensitivity, accuracy, positive and negative predictive values among the parameters studied in the cohort.

Conclusions

Within the study cohort, LASER was shown to have moderate positive correlation with RVEF derived by CMR and more favorable diagnostic performance for detecting RV systolic dysfunction compared to conventional echocardiographic parameters while being simple to obtain and less dependent on image quality than FAC and emerging techniques.
Principles and application of tunnel gravity full-space positioning and detection method for deep high-density vertical orebodies
Authors: Wang Jiyu , Han Runsheng , Li Wenyao , Cheng Ruihong
Published: September 2022

Considering the needs of current deep mineral exploration and development, the tunnel gravity exploration method is advantageous, as it is unaffected by electromagnetic interference, is hardly affected by terrain, has a high detection accuracy, and overcomes the multi-solution problem of geophysical anomalies. Herein, to systematically explain the distribution law and principle of the tunnel gravity method in spatial position prediction, a systematic study was performed on upright orebodies, and 18 types of positive and negative combination rules of spatial distribution anomalies are proposed. The method is used for the detection of concealed ore in the deep part of the Huangshaping skarn-type deposit in southern Hunan, China, and accurate results are obtained. The results indicate that tunnel gravity exploration solves the problem of orebodies located in the deep parts of a high-density vertical orebody when a single tunnel or multiple tunnels are detected. This study not only extends the theory and method of tunnel gravity exploration but also provides an important basis for the layout of deep exploration projects.
The possibilities and potential of a pedagogical partnership between university and community-based initial teacher educators for LGBTQ+ specific inclusion and diversity
Authors: Murphy Gavin , Ní Dhuinn Melanie
Published: September 2022

In this study, we explore the possibilities and potential of a pedagogical partnership between university and community-based initial teacher educators for LGBTQ+-specific inclusion and diversity. We map and discuss important initial teacher education (ITE) and broader inclusion and diversity policy contexts relevant to this pedagogical innovation as part of a Sociology of Education module. We describe and conceptually frame the innovation as equity, social justice, inclusion and diversity focused, and as rooted in democratic ITE reform. We then explore its impact on student teachers by drawing on the discussion board posts and reflections required as part of the module. Based on our findings, we offer ITE system-focused, ITE programmatic and personal reflections as teacher educators to conclude in considering how such pedagogical partnerships and innovations can enhance ITE for inclusion and diversity and, fundamentally, in pursuing more democratic schools and society.
25-hydroxyvitamin D and testosterone levels association through body mass index: A cross-sectional study of young men with obesity
Authors: Damas-Fuentes Miguel , Boughanem Hatim , Molina-Vega María , Tinahones Francisco J. , Fernández-García José C. , Macías-González Manuel
Published: September 2022

Backgrounds

Vitamin D and testosterone deficiency have been widely related to obesity. However, only a few studies have investigated the effect of vitamin D on testosterone in the context of obesity, in which controversial results have been raised.

Objectives

The purpose of this study was to determine the relationship between serum 25-hydroxyvitamin D (25(OH)D) and testosterone levels in young men with different grade of obesity.

Design and methods

This cross-sectional study included 269 healthy young men with obesity (body mass index (BMI) ≥ 30 kg/m2). Participants were divided into two groups based on their serum 25(OH)D levels (134 subjects with vitamin D sufficiency and 135 participants with vitamin D deficiency, according to the 50th percentile of 25(OH)D). Serum 25(OH)D and sex hormones have been measured. The relationships between 25(OH)D, sex hormones, and obesity grades were investigated with linear and binary logistic regression analyses, as well as mediation analysis.

Results

Compared to the 25(OH)D sufficiency group, total and free testosterone levels were found to be decreased, whereas serum androstenedione levels were increased in the 25(OH)D deficiency group (p<0.05). Using multivariable lineal regression analyses, 25(OH)D was correlated with the majority of sex hormones (p<0.05). When mediation with BMI was performed, the direct effect between 25(OH)D and sex hormones disappeared, and only the indirect effect via BMI remained (demonstrating the importance of BMI). Furthermore, after controlling for age and smoking status, we discovered that total testosterone and SHBG were both significantly associated with 25(OH)D (p<0.05) in subjects with obesity type III. Using a mediation analysis, we discovered that BMI had a partial effect on the association between 25(OH)D and total testosterone levels in morbidly obese participants, indicating that a direct association between 25(OH)D and total testosterone levels, and that BMI partially mediated this association.

Conclusions

Serum 25(OH)D is associated with total testosterone levels in only those subjects with morbid obesity, suggesting a specific benefit in severe cases of obesity. Additional research is needed to elucidate possible common mechanisms.
The impact of digitalization on the practice of determining economical cadastral valuation
Authors: Bykowa Elena , Volkova Jana , Pirogova Oksana , Barykin Sergey Evgenievich , Kazaryan Ruben , Kuhtin Peter
Published: September 2022

Cadastral appraisers often use only those pricing factors that are mentioned in the National Standard of Cadastral Appraisal which leads to overestimation or underestimation of the cadastral value, therefore a shortage of budget funds and dissatisfaction among the citizens over the cadastral system of value for the taxation. This study aims to analyze the territory for the presence of local pricing factors, i.e. those that can be identified directly during zoning. Such factors can be, for example, soil quality, environmental health, proximity to waste storage, cell towers, etc. The work consists of the following steps: substantiating the composition of local cadastral value factors, collecting qualitative and quantitative values of cost factors ranking and normalizing the values of factors, checking market data for compliance with the normal distribution law, determining the type of functional dependence of prices on factors, building a model for calculating the cadastral value, analyzing the quality of a statistical calculation model. Approbation was carried out on the example of garden and garden plots located in the Belgorod region of the Russian Federation. The test results showed that the cadastral value model, which included local factors, is statistically significant and better describes the market.
Life is in the air: An expedition into the Amazonian atmosphere
Authors: Mota de Oliveira Sylvia , Duijm Elza , Stech Michael , Ruijgrok Jasmijn , Polling Marcel , Barbosa Cybelli G. G. , Cerqueira Gabriela R. , Nascimento Antônio H. M. , Godoi Ricardo H. M. , Taylor Philip E. , Wolff Stefan , Weber Bettina , Kesselmeier Jürgen
Published: September 2022

Biological particles suspended in the atmosphere have a crucial role in the dynamics of the biosphere underneath. Although much attention is paid for the chemical and physical properties of these particles, their biological taxonomic identity, which is relevant for ecological research, remains little studied. We took air samples at 300 meters above the forest in central Amazonia, in seven periods of 7 days, and used high-throughput DNA sequencing techniques to taxonomically identify airborne fungal and plant material. The use of a molecular identification technique improved taxonomic resolution when compared to morphological identification. This first appraisal of airborne diversity showed that fungal composition was strikingly different from what has been recorded in anthropogenic regions. For instance, basidiospores reached 30% of the OTUs instead of 3–5% as found in the literature; and the orders Capnodiales and Eurotiales—to which many allergenic fungi and crop pathogens belong—were much less frequently recorded than Pleosporales, Polyporales, and Agaricales. Plant OTUs corresponded mainly to Amazonian taxa frequently present in pollen records such as the genera Helicostilys and Cecropia and/or very abundant in the region such as Pourouma and Pouteria. The origin of extra-Amazonian plant material is unknown, but they belong to genera of predominantly wind-pollinated angiosperm families such as Poaceae and Betulaceae. Finally, the detection of two bryophyte genera feeds the debate about the role of long distance dispersal in the distribution of these plants.
The pattern of expression and prognostic value of key regulators for m7G RNA methylation in hepatocellular carcinoma
Authors: Chen Jianxing , Yao Shibin , Sun Zhijuan , Wang Yanjun , Yue Jili , Cui Yongkang , Yu Chengping , Xu Haozhi , Li Linqiang
Published: September 2022

N7-methylguanosine (m7G) modification on internal RNA positions plays a vital role in several biological processes. Recent research shows m7G modification is associated with multiple cancers. However, in hepatocellular carcinoma (HCC), its implications remain to be determined. In this place, we need to interrogate the mRNA patterns for 29 key regulators of m7G RNA modification and assess their prognostic value in HCC. Initial, the details from The Cancer Genome Atlas (TCGA) database concerning transcribed gene data and clinical information of HCC patients were inspected systematically. Second, according to the mRNA profiles of 29 m7G RNA methylation regulators, two clusters (named 1 and 2, respectively) were identified by consensus clustering. Furthermore, robust risk signature for seven m7G RNA modification regulators was constructed. Last, we used the Gene Expression Omnibus (GEO) dataset to validate the prognostic associations of the seven-gene risk signature. We figured out that 24/29 key regulators of m7G RNA modification varied remarkably in their grades of expression between the HCC and the adjacent tumor control tissues. Cluster one compared with cluster two had a substandard prognosis and was also positively correlated with T classification (T), pathological stage, and vital status (fustat) significantly. Consensus clustering results suggested the expression pattern of m7G RNA modification regulators was correlated with the malignancy of HCC strongly. In addition, cluster one was extensively enriched in metabolic-related pathways. Seven optimal genes (METTL1, WDR4, NSUN2, EIF4E, EIF4E2, NCBP1, and NCBP2) were selected to establish the risk model for HCC. Indicating by further analyses and validation, the prognostic model has fine anticipating command and this probability signature might be a self supporting presage factor for HCC. Finally, a new prognostic nomogram based on age, gender, pathological stage, histological grade, and prospects were established to forecast the prognosis of HCC patients accurately. In essence, we detected association of HCC severity and expression levels of m7G RNA modification regulators, and developed a risk score model for predicting prognosis of HCC patients’ progression.
Marker density and statistical model designs to increase accuracy of genomic selection for wool traits in Angora rabbits
Authors: Ning Chao , Xie Kerui , Huang Juanjuan , Di Yan , Wang Yanyan , Yang Aiguo , Hu Jiaqing , Zhang Qin , Wang Dan , Fan Xinzhong
Published: September 2022

The Angora rabbit, a well-known breed for fiber production, has been undergoing traditional breeding programs relying mainly on phenotypes. Genomic selection (GS) uses genomic information and promises to accelerate genetic gain. Practically, to implement GS in Angora rabbit breeding, it is necessary to evaluate different marker densities and GS models to develop suitable strategies for an optimized breeding pipeline. Considering a lack in microarray, low-coverage sequencing combined with genotype imputation was used to boost the number of SNPs across the rabbit genome. Here, in a population of 629 Angora rabbits, a total of 18,577,154 high-quality SNPs were imputed (imputation accuracy above 98%) based on low-coverage sequencing of 3.84X genomic coverage, and wool traits and body weight were measured at 70, 140 and 210 days of age. From the original markers, 0.5K, 1K, 3K, 5K, 10K, 50K, 100K, 500K, 1M and 2M were randomly selected and evaluated, resulting in 50K markers as the baseline for the heritability estimation and genomic prediction. Comparing to the GS performance of single-trait models, the prediction accuracy of nearly all traits could be improved by multi-trait models, which might because multiple-trait models used information from genetically correlated traits. Furthermore, we observed high significant negative correlation between the increased prediction accuracy from single-trait to multiple-trait models and estimated heritability. The results indicated that low-heritability traits could borrow more information from correlated traits and hence achieve higher prediction accuracy. The research first reported heritability estimation in rabbits by using genome-wide markers, and provided 50K as an optimal marker density for further microarray design, genetic evaluation and genomic selection in Angora rabbits. We expect that the work could provide strategies for GS in early selection, and optimize breeding programs in rabbits.
Dynamic miRNA profile of host T cells during early hepatic stages of Schistosoma japonicum infection
Authors: Giri Bikash R. , Li Shun , Fang Chuantao , Qiu Lin , Yan Shi , Pakharukova Maria Y. , Cheng Guofeng
Published: September 2022

Schistosomes undergo complicated migration in final hosts during infection, associated with differential immune responses. It has been shown that CD4+ T cells play critical roles in response to Schistosoma infections and accumulated documents have indicated that miRNAs tightly regulate T cell activity. However, miRNA profiles in host T cells associated with Schistosoma infection remain poorly characterized. Therefore, we undertook the study and systematically characterized T cell miRNA profiles from the livers and blood of S. japonicum infected C57BL/6J mice at 14- and 21-days post-infection. We observed 508 and 504 miRNAs, in which 264 miRNAs were co-detected in T cells isolated from blood and livers, respectively. The comparative analysis of T cell miRNAs from uninfected and infected C57BL/6J mice blood showed that miR-486b-5p/3p expression was significantly downregulated and linked to various T cell immune responses and miR-375-5p was highly upregulated, associated with Wnt signaling and pluripotency, Delta notch signaling pathways, etc. Whereas hepatic T cells showed miR-466b-3p, miR-486b-3p, miR-1969, and miR-375 were differentially expressed compared to the uninfected control. The different expressions of some miRNAs were further corroborated in isolated T cells from mice and in vitro cultured EL-4 cells treated with S. japonicum worm antigens by RT-qPCR and similar results were found. In addition, bioinformatics analysis combined with RT-qPCR validation of selected targets associated with the immune system and parasite-caused infectious disease showed a significant increase in the expression of Ctla4, Atg5, Hgf, Vcl and Arpc4 and a decreased expression of Fermt3, Pik3r1, Myd88, Nfkbie, Ppp1r12a, Ppp3r1, Nfyb, Atg12, Ube2n, Tyrobp, Cxcr4 and Tollip. Overall, these results unveil the comprehensive repertoire of T cell miRNAs during S. japonicum infection, suggesting that the circulatory (blood) and liver systems have distinct miRNAs landscapes that may be important for regulating T cell immune response. Altogether, our findings indicated a dynamic expression pattern of T cell miRNAs during the hepatic stages of S. japonicum infection.
Potential mouse models of coronavirus-related immune injury
Authors: Nan Fu-Yao , Wu Cai-Jun , Su Jia-Hui , Ma Lin-Qin
Published: September 2022

Basic research for prevention and treatment of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), continues worldwide. In particular, multiple newly reported cases of autoimmune-related diseases after COVID-19 require further research on coronavirus-related immune injury. However, owing to the strong infectivity of SARS-CoV-2 and the high mortality rate, it is difficult to perform relevant research in humans. Here, we reviewed animal models, specifically mice with coronavirus-related immune disorders and immune damage, considering aspects of coronavirus replacement, viral modification, spike protein, and gene fragments. The evaluation of mouse models of coronavirus-related immune injury may help establish a standardised animal model that could be employed in various areas of research, such as disease occurrence and development processes, vaccine effectiveness assessment, and treatments for coronavirus-related immune disorders. COVID-19 is a complex disease and animal models cannot comprehensively summarise the disease process. The application of genetic technology may change this status.
Role of nuclear receptor PXR in immune cells and inflammatory diseases
Authors: Sun Le , Sun Zhenzhen , Wang Qian , Zhang Yue , Jia Zhanjun
Published: September 2022

Pregnane X receptor (PXR, NR1I2), a prototypical member of the nuclear receptor superfamily, has been implicated in various processes including metabolism, immune response, and inflammation. The immune system is made up of many interdependent parts, including lymphoid organs, cells, and cytokines, which play important roles in identifying, repelling, and eliminating pathogens and other foreign chemicals. An impaired immune system could contribute to various physical dysfunction, including severe infections, allergic diseases, autoimmune disorders, and other inflammatory diseases. Recent studies revealed the involvement of PXR in the pathogenesis of immune disorders and inflammatory responses. Thus, the aim of this work is to review and discuss the advances in research associated with PXR on immunity and inflammatory diseases and to provide insights into the development of therapeutic interventions of immune disorders and inflammatory diseases by targeting PXR.
Mapping of marine lobster research: A global outlook
Authors: Azra Mohamad Nor , Jye Mok Wen , Van Doan Hien , Zekker Ivar , Abdullah Muhammad Fuad , Abd Latif Zulkiflee , Noor Mohd Iqbal Mohd
Published: September 2022

This study examined research and development of the commercially important marine lobster, in terms of descriptive metadata and scientometric analysis. We consider a collection of over 9,578 related articles to assess literature patterns and research development trends related to marine lobsters as a topic. Web of Science Core Collection was used to identify, collate, and generate publication trends, a list prominent authors and affiliations involved, countries that actively participated, and the co-citation analysis of the references as well as impactful articles and keywords. There were 149 different countries or states that had relevant publications on lobster research. We found an increase in the number of publications over time, with the USA having the most number of publications, followed by Australia and Canada. A total of 17,782 authors were involved in the field of lobster studies. Canadian researchers had the highest citation count for marine lobster research. Surprisingly, the most impactful keyword was crayfish, followed by neuron and amino acid sequence. Our study identifies the multidisciplinary nature in marine lobster research, which includes fields such as neuroscience and developmental genetics. We find that lobster scientific publications increasingly center on the broader coverage areas of science such as taxonomy and basic biology.
Estimation of inorganic crystal densities using gradient boosted trees
Authors: Zhao Jesse
Published: September 2022

Density is a fundamental material property that can be used to determine a variety of other properties and the material’s feasibility for various applications, such as with energetic materials. However, current methods for determining density require significant resource investment, are computationally expensive, or lack accuracy. We used the properties of roughly ∼15,000 inorganic crystals to develop a highly accurate machine learning algorithm that can predict density. Our algorithm takes in the desired crystal’s chemical formula and generates 249 predictors from online materials databases, which are fed into a gradient boosted trees model. It exhibits a strong predictive power with an R2 of ∼99%.