bluuebunny/crossref_metadata_2025 huggingface dataset:
Supported self-management in community stroke rehabilitation: what is it and how does it work? A protocol for a realist evaluation study
Authors: Kidd Lisa , Millar Julie Duncan , Mason Helen , Quinn Terry , Gallacher Katie I , Jones Fiona , Fisher Rebecca J , Lebedis Therese , Barber Mark , Brennan Katrina , Smith Mark
Published: January 2022

Introduction

A growing evidence base demonstrates the effectiveness of supported self-management in stroke for stroke survivors and their families. However, there is significant variation in its implementation in community stroke care and little understanding about how supported self-management works and is delivered across different settings, models used and contexts of community stroke rehabilitation.

Methods and analysis

Using a mixed method, realist approach across two phases, this protocol describes a study on community-based supported self-management. The aim is to identify the mechanisms and outcomes of supported self-management in stroke and to understand how supported self-management is implemented in different contexts of community stroke rehabilitation. Phase 1 involves (1) a realist synthesis, (2) a scoping and mapping of current community rehabilitation settings and (3) a Q-methodology study to develop initial programme theories about how community-based supported self-management works, for whom and in what contexts. Phase 2 involves realist informed interviews/focus groups with stroke survivors, community rehabilitation practitioners and team managers from across Scotland to test and refine programme theories and an explanatory model for how supported self-management works across different contexts of community-based stroke rehabilitation.

Ethics and dissemination

Ethical approval and R&D approvals have been granted from East of Scotland Research Ethics Committee (REC reference number: 19/ES/0055) and participating NHS boards. An understanding of how, for whom and in what contexts community-based supported self-management works will help to strengthen its delivery in practice. Such an understanding will enable the design of context-specific recommendations for policy and practice that genuinely reflect the challenges in implementing supported self-management in community stroke care. Results will be disseminated to clinical partners working in community stroke rehabilitation, stroke survivors and families and to policymakers and third sector partners involved in the provision of long-term support for people affected by stroke.

PROSPERO registration number

CRD42020166208.
MArkerless image Guidance using Intrafraction Kilovoltage x-ray imaging (MAGIK): study protocol for a phase I interventional study for lung cancer radiotherapy
Authors: Mueller Marco , Booth Jeremy , Briggs Adam , Jayamanne Dasantha , Panettieri Vanessa , Senthi Sashendra , Shieh Chun-Chien , Keall Paul
Published: January 2022

Introduction

In radiotherapy, tumour tracking leads the radiation beam to accurately target the tumour while it moves in a complex and unpredictable way due to respiration. Several tumour tracking techniques require the implantation of fiducial markers around the tumour, a procedure that involves unnecessary risks and costs. Markerless tumour tracking (MTT) negates the need for implanted markers, potentially enabling accurate and optimal radiotherapy in a non-invasive way.

Methods and analysis

We will perform a phase I interventional trial called MArkerless image Guidance using Intrafraction Kilovoltage x-ray imaging (MAGIK) to investigate the technical feasibility of the MTT technology developed at the University of Sydney (sponsor). 30 participants will undergo the current standard of care lung stereotactic ablative radiation therapy, with the exception that kilovoltage X-ray images will be acquired continuously during treatment delivery to enable MTT. If MTT indicates that the mean lung tumour position has shifted >3 mm, a warning message will be displayed to indicate the need for a treatment intervention. The radiation therapist will then pause the treatment, shift the treatment couch to account for the shift in tumour position and resume the treatment. Participants will be implanted with fiducial markers, which act as the ground truth for evaluating the accuracy of MTT. MTT is considered feasible if the tracking accuracy is <3 mm in each dimension for >80% of the treatment time.

Ethics and dissemination

The MAGIK trial has received ethical approval from The Alfred Human Research Ethics Committee and has been registered with ClinicalTrials.gov with the Identifier: NCT04086082. Estimated time of first recruitment is early 2022. The study recruitment and data analysis phases will be performed concurrently. Treatment for all 30 participants is expected to be completed within 2 years and participant follow-up within a total duration of 7 years. Findings will be disseminated through peer-reviewed publications and conference presentations.

Trial registration number

NCT04086082; Pre-result.
Interventions to reduce post-traumatic stress disorder symptoms in health care professionals from 2011 to 2021: a scoping review
Authors: Qian Jialu , Wang Weihong , Sun Shiwen , Liu Lu , Sun Yaping , Yu Xiaoyan
Published: January 2022

Objectives

This scoping review aimed to describe available interventions for decreasing (post-traumatic stress disorder) PTSD symptoms among healthcare professionals in hospital care.

Method

A scoping review was conducted following Arksey and O’Malley’s framework. PubMed, EMBASE, Cochrane Library, CINAHL, PsycINFO, Web of Science, Scopus and ProQuest were searched for original research published in English from 2011 to 2021, on 8 July 2021. We included studies that described interventions that focused on reducing the PTSD symptoms of healthcare professionals. A narrative synthesis was adopted to synthesise the data.

Results

A total of eight studies out of 2558 articles were identified. Six used a quantitative study design and two adopted qualitative methods. cognitive behavioural therapy and mindfulness-based interventions were the most commonly adopted. Most studies used a combination of different intervention strategies. Trauma-related knowledge, emotion regulation and relaxation skill training, and psychological support from peers and psychologists were three core intervention components. The duration ranged from 2 weeks to 6 months. Healthcare professionals who participated in training programmes reported both positive experiences and suggestions for the improvement of PTSD-reducing interventions in their qualitative feedback.

Conclusions

The scoping review provides a practical summary of the intervention characteristics for reducing the PTSD symptoms of healthcare professionals. Hospitals and managers could use the overview of interventions to assist healthcare professionals with PTSD symptoms. More research investigating the effects of PTSD symptom-reducing interventions for healthcare professionals with appropriate follow-up assessments is needed in the future.
Diversity of physicians in leadership and academic positions in Alberta: a cross-sectional survey
Authors: Ruzycki Shannon M , Roach Pamela , Ahmed Sofia B , Barnabe Cheryl , Holroyd-Leduc Jayna
Published: January 2022

Background

Efforts to reduce barriers and disparities faced by marginalised physicians are limited by a lack of data on the current diversity of the Canadian physician workforce. We aimed to characterise the diversity of the Albertan physician workforce.

Methods

This cross-sectional survey, open to all Albertan physicians from 1 September 2020 to 6 October 2021, measured the proportion of physicians from traditionally under-represented groups, including those with diverse gender identities, disabilities and from racial minorities.

Results

There were 1087 respondents (9.3% response rate); of whom 33.4% identified as cisgender men (n=363), 46.8% as cisgender women (n=509) and less than 3% as gender diverse. Fewer than 5% were members of the LGBTQI2S+community. Half were white (n=547), 4.6% were black (n=50) and fewer than 3% were Indigenous or Latinx. Over one-third reported a disability (n=368, 33.9%). There were 303 white cisgender women (27.9%), 189 white cisgender men (17.4%), 136 black, Indigenous or person of colour (BIPOC) cisgender men (12.5%) and 151 BIPOC cisgender women (13.9%). Compared with BIPOC physicians, white participants were over-represented in leadership positions (64.2% and 32.1%; p=0.06) and academic roles (78.7% and 66.9%; p<0.01). Cisgender women had less often applied for academic promotion than cisgender men (85.4% and 78.3%, respectively, p=0.01), and BIPOC physicians had been denied promotion more frequently (7.7% compared with 4.4%; p=0.47).

Conclusion

Many Albertan physicians may experience marginalisation through at least one protected characteristic. There were race-based and gender-based differences in experiences of medical leadership and academic promotion which may explain observed disparities in these positions. To increase diversity and representation in medicine, medical organisations should focus on inclusive cultures and environments. Universities should focus efforts on supporting BIPOC physicians, especially BIPOC cisgender women, in applying for promotion.
Therapeutic effect of rupatadine against l-arginine-induced acute pancreatitis in rats: role of inflammation
Authors: Mohamed Mervat Z. , Mohammed Hanaa H. , Khalaf Hanaa M.
Published: January 2022

Acute pancreatitis (AP) is an abrupt inflammatory disorder causing high morbidity and mortality. As AP is an insidious medical emergency, a curative modality is required instead of a preventive measure. Thus, we investigated the possible curative effect of rupatadine on a rat model of AP. Rupatadine is a potent histamine receptor 1 (H1R) and platelet-activating factor (PAF) blocker. We used four groups of six Wistar rats as follows: the control group received vehicle; the rupatadine control group received rupatadine as 6 mg/kg orally; the AP group received l-arginine intraperitoneally, and the treatment group received rupatadine at 1, 6, and 24 h after l-arginine injection. The levels of serum amylase, pancreatic oxidative parameters, and pancreatic cytokines were measured. PAF, histamine, and myeloperoxidase levels were determined in the pancreas. Histopathological and immunohistochemical examinations were performed to determine nuclear factor kappa-B (NF-κB) and caspase 3 expressions. Oxidative damage and severe inflammation were detected in the pancreas of the AP group. Rupatadine reduced the oxidative damage and the levels of proinflammatory cytokines, PAF, histamine, myeloperoxidase, NF-κB, and caspase 3 expressions. It restored the pancreatic acini to almost normal condition. Rupatadine induced important anti-inflammatory and antiapoptotic effects against l-arginine-induced AP.
AVS-YOLO: Object Detection in Aerial Visual Scene
Authors: Ma You , Chai Lin , Jin Lizuo , Yu Yafeng , Yan Jun
Published: January 2022

Difficult object detection and class imbalance in object detection are the two main challenges faced by aerial image object detection. Difficult objects include small objects, objects of scale variation and objects with serious background interference. Class imbalances come from the number of different classes of objects and sampling of positive and negative samples. Due to these challenges, conventional object detection models usually cannot effectively detect objects in aerial images, especially in the balance between network speed and accuracy. In this paper, the YOLOv3 network structure was improved and an object detection method under the aerial visual scene (AVS-YOLO) was proposed. By introducing a type of densely connected feature pyramid strategy, a scale-aware attention module was constructed, considering both residual dense network blocks and the median-frequency-balancing mechanism. On this basis, an algorithm with ideal speed and accuracy for object detection is obtained. To verify the effectiveness of the algorithm, AVS-YOLO and YOLOv3 were both used to test the VisDrone-DET2019 and UAVDT. The experimental results show that the AP of AVS-YOLO increases by 6.22% and 5.09% on the VisDrone2019 and UAVDT datasets, respectively, compared with YOLOv3. In addition, the AP of AVS-YOLO is 1.82% higher than that of YOLOv4 on the VisDrone2019 dataset. In terms of detection speed, AVS-YOLO can process 31.8 frames per second on a single Nvidia GTX 2080Ti GPU, compared with 44.1 frames per second for YOLOv3. Compared with the other one-stage network in the field of object detection, AVS-YOLO currently achieves the state-of-the-art performance with similar calculation amount on this dataset.
Multi-domain Spoken Language Understanding Using Domain- and Task-aware Parameterization
Authors: Qin Libo , Wei Fuxuan , Ni Minheng , Zhang Yue , Che Wanxiang , Li Yangming , Liu Ting
Published: January 2022

Spoken language understanding (SLU) has been addressed as a supervised learning problem, where a set of training data is available for each domain. However, annotating data for a new domain can be both financially costly and non-scalable. One existing approach solves the problem by conducting multi-domain learning where parameters are shared for joint training across domains, which is
domain-agnostic
and
task-agnostic
. In the article, we propose to improve the parameterization of this method by using domain-specific and task-specific model parameters for fine-grained knowledge representation and transfer. Experiments on five domains show that our model is more effective for multi-domain SLU and obtain the best results. In addition, we show its transferability when adapting to a new domain with little data, outperforming the prior best model by 12.4%. Finally, we explore the strong pre-trained model in our framework and find that the contributions from our framework do not fully overlap with contextualized word representations (RoBERTa).
Learning of Martial Arts Action Decomposition Method Based on Image Recognition
Authors: Zhou Yuanbing , Du Yufeng , Lu Xiaochun , Chen Haiou
Published: January 2022

In order to improve the effective guidance of martial arts movements, a decomposition method of martial arts movements based on image recognition is proposed. First of all, visual image target sampling of martial arts action is performed, and most of the noise background is eliminated through morphological gradient operation. Then, the contour edge of the human body is obtained, the contour edge of each frame of the video is extracted, and the accumulation is realized in the same image. Using accumulation, the edge image calculates the grid-based HOG to obtain the image action feature vector. Secondly, using the improved dynamic time warping theory combined with the characteristics of the angle change of each joint under the action time sequence, the joint change sequence among various martial arts movements can be identified in order to realize the decomposition process of martial arts actions based on image recognition. The experimental results show that the use of image recognition can effectively decompose martial arts movements.
Action Mechanism Underlying Improvement Effect of Fuzi Lizhong Decoction on Nonalcoholic Fatty Liver Disease: A Study Based on Network Pharmacology and Molecular Docking
Authors: Luo Zheng , Xia Lu-Yun , Tang Yu-Qin , Huang Lili , Liu Dan , Huai Wen-Ying , Zhang Chun-Jiang , Wang Yan-Qiu , Xie Yong-Mei , Yin Qiao-Zhi , Chen Yun-Hui , Zhang Tian-E.
Published: January 2022

Objective. This study aimed to decipher the bioactive compounds and potential mechanism of traditional Chinese medicine (TCM) formula Fuzi Lizhong Decoction (FLD) for nonalcoholic fatty liver disease (NAFLD) treatment via an integrative network pharmacology approach. Methods. The candidate compounds of FLD and its relative targets were obtained from the TCMSP and PharmMapper web server, and the intersection genes for NAFLD were discerned using OMIM, GeneCards, and DisGeNET. Then, the PPI and component-target-pathway networks were constructed. Moreover, GO enrichment and KEGG pathway analysis were performed to investigate the potential signaling pathways associated with FLD’s effect on NAFLD. Eventually, molecular docking simulation was carried out to validate the binding affinity between potential core components and key targets. Results. A total of 143 candidate active compounds and 129 relative drug targets were obtained, in which 61 targets were overlapped with NAFLD. The PPI network analysis identified ALB, MAPK1, CASP3, MARK8, and AR as key targets, mainly focusing on cellular response to organic cyclic compound, steroid metabolic process, and response to steroid hormone in the biological processes. The KEGG pathway analysis demonstrated that 16 signaling pathways were closely correlated with FLD’s effect on NALFD with cancer pathways, Th17 cell differentiation, and IL-17 signaling pathways as the most significant ones. In addition, the molecular docking analysis revealed that the core active compounds of FLD, such as 3′-methoxyglabridin, chrysanthemaxanthin, and Gancaonin H, had a high binding activity with such key targets as ALB, MAPK1, and CASP3. Conclusions. This study suggested that FLD exerted its effect on NAFLD via modulating multitargets with multicompounds through multipathways. It also demonstrated that the network pharmacology-based approach might provide insights for understanding the interrelationship between complex diseases and interventions of the TCM formula.
Molecular Mechanism of Tetramethylpyrazine Ameliorating Neuroexcitotoxicity through Activating the PKA/CREB Signaling Pathway
Authors: Tong Hongxuan , Wang Kaili , Wang Xiting , Lu Tao
Published: January 2022

Background. Excitotoxicity plays a key role in nervous system disease and can trigger a critical cascade of reaction which affects cell viability and promotes neuronal death. Tetramethylpyrazine (TMP) reveals its effect in the treatment of neurovascular diseases by antiapoptosis. Recently, there were several studies that demonstrated that the PKA/CREB signaling pathway played a role in neural disease because of excitotoxicity, such as stroke, AD, and Parkinson’s disease. In this study, we wanted to focus on the protective effect of tetramethylpyrazine against excitotoxicity through the PKA/CREB signaling pathway. Methods. In order to verify whether tetramethylpyrazine can attenuate excitotoxicity through the PKA/CREB signaling pathway, we first used molecular docking technology to predict the combinational strength and mode of tetramethylpyrazine with the proteins in the PKA/CREB signaling pathway. Then, we determined the optimal concentration and time according to the model effect of glutamate (Glu) with different concentration gradients and action times in PC12 cells. After the determination of concentration and time of glutamate in the previous step as the model way, tetramethylpyrazine was added to determine its influence on the cell viability under different doses and times. The TUNEL assay and flow cytometry were used to detect apoptosis. RT‐PCR was used to detect the expression of Bcl‐2, Bax, PKA, and 5CREB genes, and Western blot was used to detect the expression of these factors. Result. Tetramethylpyrazine had a good docking score (‐5.312) with PKA and had a moderately docking score (‐3.838) with CREB. The CCK‐8 cell activity assay showed that the activity of PC12 cells decreased gradually with the increase in glutamate concentration and time, and PC12 cells were treated with 10 mM/L glutamate (the half of the inhibitory concentration (IC50)) for 12 hours. Then, the cell viability increased gradually following the increased concentration of tetramethylpyrazine. When PC12 cells were treated with 0.1 mM/L tetramethylpyrazine, the cell viability was increased significantly compared with the control group (P < 0.05). The TUNEL assay and flow cytometry also showed that tetramethylpyrazine could decrease the apoptosis induced by glutamate. In the result of RT‐PCR, the transcriptional levels of Bcl‐2, PKA, and CREB were increased and Bax was decreased. Meanwhile, Western blot showed that expression levels of Bcl‐2, PKA, CREB, and p‐CREB were increased and Bax was decreased. Conclusions. This study provided evidence that tetramethylpyrazine can protect against apoptosis caused by neuroexcitotoxicity and the protective mechanism is closely related to the activation of the PKA/CREB signaling pathway.
Digital Transformation of Manufacturing Enterprises: An Empirical Study on the Relationships between Digital Transformation, Boundary Spanning, and Sustainable Competitive Advantage
Authors: Xue Fang , Zhao Xiaokang , Tan Yunqing
Published: January 2022

This paper investigates the relationships between digital transformation, boundary spanning, and sustainable competitive advantage of manufacturing enterprises through an analysis of data from 127 manufacturing enterprises. Our main research findings are as follows. First, digital transformation has a positive impact on sustainable competitive advantage of manufacturing enterprises. Compared with the degree of transformation, technology readiness has a stronger influence on sustainable competitive advantage. Second, digital transformation has a positive impact on boundary spanning of manufacturing enterprises. Third, boundary spanning of manufacturing enterprises has a positive impact on their sustainable competitive advantage. Fourth, digital transformation affects the acquisition of sustainable competitive advantages of enterprises through boundary spanning, where the direct role of digital transformation accounts for 75% and the mediation effect of boundary spanning accounts for 25% of the total effect. Fifth, the mediation effect of boundary spanning on the relationship between digital transformation and sustainable competitive advantage is mainly realized through boundary spanning depth, while the mediation effect of boundary spanning breadth on the relationship between digital transformation and sustainable competitive advantage is insignificant. Our findings can help realize the digital transformation of manufacturing enterprises and achieve their sustainable competitive advantage.
Analysis of Collaborative Driving Effect of Artificial Intelligence on Knowledge Innovation Management
Authors: Liu Qi
Published: January 2022

Artificial intelligence (AI) plays a connotative driving role in cross-border knowledge and factor identification of innovation management. This study explores the collaborative driving effects and influence factors of artificial intelligence on knowledge innovation management. Based on the artificial intelligence application data in knowledge innovation management from 2011 to 2020, this paper adopts the synergy model and the adiabatic elimination to empirically test the influence mechanism and key factors of AI for knowledge innovation management. The results showed that artificial intelligence had a significant impact on dynamic elements, capacity elements, environmental elements of knowledge flow, and stock management. AI made endogenous impacts on the promotion of knowledge flow ability and network diffusion. AI technology promoted the formation of the original technological advantages of innovation and had obvious automatic recognition function for new knowledge, which stimulated the main internal transmission power of knowledge innovation. Furthermore, AI actuated energy level of original innovation and progressive achievements of cutting-edge technology, which mainly came from the deep runoff knowledge of innovation system. Knowledge network affected the transmission efficiency and retention proportion of deep runoff knowledge. The penetration proportion of artificial intelligence determined cooperation space of intelligent industry and application direction of integrated knowledge.
Normobaric Oxygen Therapy in Acute Stroke: A Systematic Review and Meta-Analysis
Authors: Mahmood Ammad , Neilson Sam , Biswas Viveka , Muir Keith
Published: January 2022

Purpose: Normobaric oxygen (NBO) is potentially a readily accessible neuroprotective therapy. We undertook a systematic review to assess NBO in acute stroke. Methods: MEDLINE, EMBASE, and CENTRAL databases were searched to December 2020. Randomized controlled trials of NBO administered <7 days after stroke to normoxic patients with no other indication for oxygen were identified. Data on early neurological recovery; functional outcome; mortality; oxygen saturation, and imaging markers were collected. Findings: Fifteen publications involving 12 cohorts and 9,255 participants were identified. One study with 8,003 participants had low risk of bias, but the designs of smaller trials had limitations. Ninety-seven per cent of participants were in studies of low-flow oxygen (≤4 L/min). 82.8% had ischaemic stroke. Median time to treatment was 19.3 h. Meta-analysis demonstrated no significant effect on: reduction in National Institutes of Health Stroke Scale at 7 days in all stroke or ischaemic stroke only (mean difference −0.16 [−1.11 to 0.80] and −0.73 [−3.54 to 2.08], respectively); modified Rankin scale at 3–6 months of follow-up (combined standardized mean difference [SMD] −0.08 [−0.38 to 0.22]; 3 months SMD −0.01 [−0.03 to 0.029]; 6-month SMD −0.20 [−1.49 to 1.09]), or mortality (odds ratio 1.15 [0.87–1.53]). Discussion: The majority of patients were administered low-flow oxygen in the sub-acute phase. Intervention strategies targeted at modification of early tissue survival (higher oxygen delivery and administration at early time points when significant volumes of viable tissue persist) have not been tested adequately. Conclusion: Studies of NBO have shown no significant effect on early neurological recovery, functional outcome, or mortality in acute stroke. Oxygen has been predominantly low-flow and commenced in the sub-acute phase.
Metabolic Surgery: Paradigm Shift in Metabolic Syndrome/Diabetes Therapy
Authors: Rühle Annika , Billeter Adrian T. , Müller-Stich Beat P.
Published: January 2022

Background: Obesity and metabolic disorders as type 2 diabetes (T2D), nonalcoholic fatty liver disease (NAFLD) or better called metabolic dysfunction fatty liver disease (MAFLD), arterial hypertension (AHT), and obstructive sleep apnea syndrome (OSAS) show a rising prevalence. The increased cardiovascular risk is one of the main causes for death of obese, metabolic ill patients. Sustainable and efficient therapeutic options are needed. Summary: Metabolic surgery not only permits a substantial and lasting weight loss but also ameliorates metabolic co-morbidities and reduces cardiovascular risk and mortality of obese patients. Most existing data focused on T2D, but evidence for other metabolic co-morbidities such as NAFLD, AHT, and OSAS increase constantly. After metabolic surgery, glycemic control of diabetic patients is superior compared to conservative treatment. Also, diabetes related micro- and macrovascular complications are reduced after surgery, and the median life expectancy is over 9 years longer. In patients with MAFLD, metabolic surgery leads to reduction of steatosis and fibrosis while the risk to develop a hepatocellular carcinoma is reduced significantly. Patients with OSAS have an improved lung function and continuous pressure airway treatment during the night is unnecessary in many patients. Patients with AHT need significantly less or even no antihypertensive medication after surgery and the hazard ratio of death is reduced by 49.2%. Therefore, the focus in treating obese and metabolic ill patients is no longer on pure weight loss but on improvement of co-morbidities and reduction of mortality. This is reflected by the updated S3-guidelines of 2018 that provide nationally established consistent guidelines with clear indications for metabolic surgery no longer focusing on body mass index (BMI) only. This article aims to give an overview over the existing literature concerning surgical treatment options for metabolic syndrome. Key Messages: Metabolic co-morbidities impact life-quality and life expectancy of obese patients. Metabolic surgery offers the chance to treat those metabolic co-morbidities independently of the preoperative BMI and should be considered early as a treatment option for obese patients.
Gambaran Klinikopatologi Parapsoriasis
Authors: Puspitasari Galuh , Yuniaswan Anggun , Retnani Diah
Published: January 2022

Parapsoriasis merupakan penyakit kulit yang mencerminkan tumpang tindih klinis termasuk kronisitas, penyebab yang idiopatik, recalcitrans terhadap terapi, dan lesi nonpruritik, yang menyerupai psoriasis. Terdapat 2 bentuk parapsoriasis yaitu Small Plaque Parapsoriasis (SPP) dan Large Plaque Parapsoriasis (LPP). Banyak penyakit kulit yang memiliki gejala menyerupai parapsoriasis, sehingga diagnosisnya sulit ditegakkan. Oleh karena itu pemeriksaan histopatologi dan imunohistokimia perlu dilakukan. Parapsoriasis dikarakteristikkan dengan infiltrat limfoid kutaneus superfisial yang terdiri dari sel T pada pemeriksaan histopatologi baik pada LPP maupun SPP. Namun infiltrat LPP sering mengandung limfosit dengan inti cerebriform (sel Lutzner) yang mirip dengan sel Sezary pada Mycosis fungoides (MF). Pemeriksaan imunohistokimia CD3 dapat menunjukkan gambaran sel T tersebut normal atau atipikal jika mengarah suatu keganasan. Oleh karena itu, evaluasi densitas sel T pada gambaran histopatologi dan pemeriksaan imunohistokimia CD3 dapat membantu menegakkan diagnosis parapsoriasis, serta untuk mengenali tanda-tanda keganasan mengarah pada MF.
O contexto de produção e as fotografias nos arquivos pessoais: um estudo nos artigos de periódicos da Ciência da Informação e Arquivologia
Authors: Mariz Anna Carla Almeida , Cordeiro Rosa Inês de Novais
Published: January 2022

Estudo resultante de pesquisa bibliográfica sobre arquivos pessoais, nos quais normalmente são encontrados documentos de gêneros diversos, entre eles as fotografias com muita frequência, evidenciando-se a importância desses acervos para a memória individual e familiar. São as características organicidade e autenticidade que qualificam os arquivos pessoais e suas fotografias como tais e os diferem das coleções. Este trabalho tem como objetivo verificar como são enfocados esses acervos na literatura em língua portuguesa de artigos de periódicos, com destaque para o estudo da questão do contexto de produção das fotografias nos arquivos pessoais e a observância desses registros visuais, a partir das seguintes categorias de análise:  enfoque do tema, campo empírico e resultados. O tratamento técnico desses documentos apresenta especificidades, e cumpre examinar se a literatura da área vem registrando essas mudanças quanto aos aspectos teóricos e empíricos de organização e no que se refere ao crescimento desses acervos em quantidade e em importância. Para tanto, foi realizada pesquisa bibliográfica na literatura em língua portuguesa em artigos de periódicos da área da Ciência da Informação e Arquivologia, com uma abordagem quanti-qualitativa e observância às categorias de análise. Constata-se que, da mesma forma que a literatura sobre acervos fotográficos pouco evidencia os arquivos pessoais, o inverso também acontece: a literatura sobre arquivos pessoais pouco ressalta os documentos fotográficos, um gênero documental encontrado com muita frequência nos acervos pessoais e familiares. São dois temas que têm relação, porém a literatura contemplando a interseção entre eles é muito escassa, especialmente no recorte escolhido.
Mediação da leitura e literatura na educação infantil para o desenvolvimento integral
Authors: Abreu Ana Caroline , Bedin Jéssica , Sena Priscila  Machado Borges
Published: January 2022

Apresenta pesquisa cujo objetivo consistiu em analisar a literatura infantil e sua mediação no desenvolvimento integral da criança, de acordo com a Base Nacional Comum Curricular (BNCC) para o desenvolvimento integral da criança de 0 a 5 anos. Trata-se de pesquisa bibliográfica documental com abordagem qualitativa, a partir da busca na Base de Dados em Ciência da Informação (BRAPCI) onde recuperou-se documentos pelos termos mediação da leitura e mediação da literatura para obter a conceituação e as práticas de mediação em bibliotecas e com análise documental do documento Base Nacional Comum Curricular para obter subsídios do que é a formação integral do sujeito. Observa-se que existem na literatura científica conceituações incipientes quanto a diferenciação entre mediação da leitura e mediação da literatura, contudo, elas são diferentes, pois enquanto a mediação da leitura envolve aspectos da alfabetização, mediação da literatura aborda práticas que relacionam ao conhecimento de mundo e lazer. No que tange às práticas realizadas em bibliotecas, podem ser adaptadas e embasadas nos objetivos da BNCC para o desenvolvimento integral para crianças de 0 a 5 anos, que são o foco deste estudo, a partir da literatura infantil e mediação da literatura. Por meio da literatura infantil e sua mediação em biblioteca escolar é possível iniciar o desenvolvimento integral de crianças de 0 a 5 anos. Com práticas alinhadas aos objetivos da BNCC, adaptando-se às atividades para a respectiva faixa etária, pode-se ter a formação de sujeitos críticos e capazes de se desenvolverem plenamente no âmbito educacional.
Estudo da paisagem de Goiânia-GO
Authors: Rodrigues Leandra de Brito , Kunz Sidelmar Alves da Silva
Published: January 2022

Tendo em vista o acervo arquitetônico que marca a paisagem de Goiânia, esta pesquisa expõe a perspectiva dos cidadãos referente ao patrimônio cultural dessa cidade. O recorte da investigação é a área do Setor Central, onde as pessoas abordadas estão mais próximas à maioria dos bens tombados. Resgata-se o conceito de patrimônio cultural e se discute a sua abrangência, considerando os estilos arquitetônicos de Goiânia. Os resultados sinalizam no sentido que a maioria das pessoas tem noção do que significa patrimônio cultural, porém não conhecem bem a história de Goiânia, nem o estilo Art Déco que representa a cidade.
Twenty Years of Studying AngII (Angiotensin II)-Induced Abdominal Aortic Pathologies in Mice: Continuing Questions and Challenges to Provide Insight Into the Human Disease
Authors: (澤田悠)  , (吕红)  , Cassis Lisa A. , Daugherty Alan
Published: January 2022

AngII (angiotensin II) infusion in mice has been used to provide mechanistic insight into human abdominal aortic aneurysms for over 2 decades. This is a technically facile animal model that recapitulates multiple facets of the human disease. Although numerous publications have reported abdominal aortic aneurysms with AngII infusion in mice, there remain many fundamental unanswered questions such as uniformity of describing the pathological characteristics and which cell type is stimulated by AngII to promote abdominal aortic aneurysms. Extrapolation of the findings to provide insight into the human disease has been hindered by the preponderance of studies designed to determine the effects on initiation of abdominal aortic aneurysms, rather than a more clinically relevant scenario of determining efficacy on the established disease. The purpose of this review is to enhance understanding of AngII-induced abdominal aortic pathologies in mice, thereby providing greater insight into the human disease.
1. Introduction
Authors: Martinez-Vargas Carmen
Published: January 2022

This book commences with an introductory chapter with a broad exposition of basic elements and theoretical points of the South African study. It situates this research in the South African higher-education context, presenting an historical review of this country’s institutions and their current challenges. The text explores the students’ claims for decolonisation and the subsequent revitalisation of the academic literature to contextualise the participatory case study.
The Effect of an Equatorial Continent on the Tropical Rain Belt. Part II: Summer Monsoons
Authors: Biasutti Michela , Hill Spencer , Voigt Aiko
Published: January 2022

The TRACMIP (Tropical Rain Belts with an Annual Cycle and Continent Model Intercomparison Project) ensemble includes slab-ocean aquaplanet control simulations and experiments with a highly idealized narrow tropical continent (0°–45°W, 30°S–30°N). We compare the two setups to contrast the characteristics of oceanic and continental rainbands and investigate monsoon development in GCMs with CMIP5-class dynamics and physics. Over land, the rainy season occurs close to the time of maximum insolation. Other than in its timing, the continental rainband remains in an ITCZ-like regime akin to deep-tropical monsoons, with a smooth latitudinal transition, a poleward reach only slightly farther than that of the oceanic ITCZ (about 10°), and a constant width throughout the year. This confinement of the monsoon to the deep tropics is the result of a tight coupling between regional rainfall and circulation anomalies: ventilation of the lower troposphere by the anomalous meridional circulation is the main limiting mechanism, while ventilation by the mean westerly jet aloft is secondary. Comparison of two subsets of TRACMIP simulations indicates that a low heat capacity determines, to a first degree, both the timing and the strength of the regional solsticial circulation; this lends support to the choice of idealizing land as a thin slab ocean in much theoretical literature on monsoon dynamics. Yet, the timing and strength of the monsoon are modulated by the treatment of evaporation over land, especially when moisture and radiation can interact. This points to the need for a fuller exploration of land characteristics in the hierarchical modeling of the tropical rainbands.
Organizational responses to political sanctions: Voluntary state co-optation and strategic acquiescence in China’s futures market
Authors: Wei Hua , Hassard John
Published: January 2022

What can an organization do to survive when its existence is a problem for political institutions? Drawing information from China’s futures market, we address this question through analysing forms of corporate political activity (CPA) among the nation’s ‘red capitalists’, notably using CPA concepts to decode power dynamics between Chinese financial organizations and the state. Deploying a multi-method, longitudinal and reflexive case approach, we explain how a ‘rogue’ futures exchange was targeted by a major regulatory crackdown, yet ostensibly survived; principally by negotiating new forms of institutional control. This saw the enrolling of state actors and resources to shape politically acceptable forms of corporate behaviour, a process framed theoretically through the concept of voluntary co-optation; or the strategic steps the focal organization took to yield power to the state in return for enhanced corporate legitimacy. Constructing a two-phase empirical account, including detailed diagrammatic explanations, the article assesses how a range of lobbying-oriented and guanxi-related practices influenced the organization in repositioning and reconstructing itself through progressive strategic acquiescence, as forces of political capital (‘whom you know’) and intellectual capital (‘what you know’) combined to shape the firm’s decision responses and bolster its functional credibility amid a hostile institutional climate.
Pope Francis, Civil Unions, and Same-Sex Marriage: Theological Reflections
Authors: Lawler Michael G. , Salzman Todd A.
Published: January 2022

This essay examines civil union and same-sex marriage in relation to the Catholic doctrine of heterosexual marriage. It concludes of civil union that it is a civil reality, the concern of civil, not ecclesiastical, authority. It finds in Catholic marriage three bonds between believing spouses, of love, of law, and of Sacrament (upper case), and argues that in same-sex marriage there are three bonds, of love, of law, and of sacrament (lower case). The spouses themselves control the bond of love, a legal authority controls the bond of law, and the belief of the spouses that their marriage is a symbol of the presence of God in the world controls the bond of Sacrament/sacrament. A conclusion of the essay is that the argument of the Church against same-sex marriage is judged to be non-probative by a majority of its members, especially of its younger members, and a change could be possible.
Beginning from the End: How Pannenberg’s Eschatological Ontology Can Offer a New Way to Place Jesus in the First Testament
Authors: Hollingsworth Andrew
Published: January 2022

I use insights from Wolfhart Pannenberg’s eschatological ontology to provide a new way of explaining how Jesus would genuinely be present in the Old, or First, Testament. Since the end of something is the logical priority in determining the fullness of that something’s meaning and identity, according to Pannenberg, then everything prior to the end awaits, or anticipates, its fullness of meaning and being. Using Pannenberg’s eschatological ontology, I argue that Jesus would first be present throughout the First Testament as he is anticipated by it. Second, I argue that the eschatological event that is Jesus himself would retroactively demonstrate and determine his presence throughout the entirety of the First Testament as well as all Scripture. I use insights from semiotics and hermeneutics to further this argument. I then conclude that this eschatological ontology would be the determining and demonstrative factor for Jesus’ presence in the First Testament.
Inhibiting Hh Signaling in Gli1+ Osteogenic Progenitors Alleviates TMJOA
Authors: Lei J. , Chen S. , Jing J. , Guo T. , Feng J. , Ho T.V. , Chai Y.
Published: January 2022

The increased prevalence of temporomandibular joint osteoarthritis (TMJOA) in children and adolescents has drawn considerable attention as it may interfere with mandibular condyle growth, resulting in dento-maxillofacial deformities. However, treatments for osteoarthritis have been ineffective at restoring the damaged bone and cartilage structures due to poor understanding of the underlying degenerative mechanism. In this study, we demonstrate that Gli1+ cells residing in the subchondral bone contribute to bone formation and homeostasis in the mandibular condyle, identifying them as osteogenic progenitors in vivo. Furthermore, we show that, in a TMJOA mouse model, derivatives of Gli1+ cells undergo excessive expansion along with increased but uneven distribution of osteogenic differentiation in the subchondral bone, which leads to abnormal subchondral bone remodeling via Hedgehog (Hh) signaling activation and to the development of TMJOA. The selective pharmacological inhibition and specific genetic inhibition of Hh signaling in Gli1+ osteogenic progenitors result in improved subchondral bone microstructure, attenuated local immune inflammatory response in the subchondral bone, and reduced degeneration of the articular cartilage, providing in vivo functional evidence that targeting Hh signaling in Gli1+ osteogenic progenitors can modulate bone homeostasis in osteoarthritis and provide a potential approach for treating TMJOA.
Employer constraints on trade union renewal in Chile
Authors: Bellido de Luna Daina
Published: January 2022

The present article explores the revitalisation strategies developed by a company-level trade union in the food manufacturing industry in Chile. Using qualitative research and building on a case study, the findings suggest that predominant renewal strategies were restructuring through mergers, a variation on the Anglo-Saxon labour-management partnership, and organising based on recruiting new members and legal mobilization. The article argues that these revitalisation strategies were implemented in relation to the deployment of the employer's trade union weakening strategies, this being the central feature that drove the renewal capabilities of the researched trade union. The article contributes to enlarge the understanding of the way employer strategies and regulatory contexts shape the union revitalization framework.
Men’s Football Fandom and the Performance of Progressive and Misogynistic Masculinities in a ‘New Age’ of UK Women’s Sport
Authors: Pope Stacey , Williams John , Cleland Jamie
Published: January 2022

This article offers an original contribution as the first to focus empirically on men football fans’ attitudes towards women’s sport in a ‘new age’ of UK media coverage, in which women’s sport has experienced a significantly increased and more positive media profile. We draw on online survey responses from 1950 men football fans of different age groups from across the UK. Our methodological approach used techniques emerging out of the principles of grounded theory. We develop a new, three-fold, theoretical model, covering men football fans’ attitudes to women in the sports nexus and men’s performances of masculinities. Our findings show evidence of a change in attitudes towards women in sport, with men performing progressive masculinities. However, there were also signs of a backlash against advances in gender equality, with men performing overtly misogynistic masculinities and covertly misogynistic masculinities.
Scale-up fabrication of PVDF-HFP nanofibrous membrane with unique surface properties for efficient separation of oil from water
Authors: Liu Zhi , Gao Bing , Huang Xiaohai , Ke Huizhen , Xu Jin
Published: January 2022

Herein, the unique wrinkled surface of polyvinylidene fluoride-hexafluoropropylene nanofibrous membrane was well developed by a one-step fabrication method just by adjusting the ratio of binary solvent and humidity. The well-tailored process was proposed complying with the evolutionary mechanism that a different volatilization temperature of binary solvent provides buffer time for the formation of a polymer/solvent-rich phase, subsequently water vapor solidifies the polymer jet, forming the unique surface on the resultant nanofiber. The intrinsic wrinkled surface structure enhances the roughness and endows the membrane with robust superhydrophobic characteristics. Meanwhile, the excellent mechanical property (stress at break 6.79 MPa, strain at break 136.8%) widens its applicability in industrial employment. Furthermore, the synthesized membrane exhibits stable results in oil–water separation in terms of good separation efficiency (>99.6%) and flux (>1100 l/m2h). This is a general approach for the synthesis of many other materials at lower cost and holds a great potential to be employed in practical engineering applications beyond the oil–water separation.
Saved by the Bell Schedule? The Effects of a Later School Start Time on High Schoolers in an Urban District
Authors: Fuller Sarah C. , Bastian Kevin C.
Published: January 2022

Later school start times have emerged as a potential policy to improve the sleep and educational outcomes of teenagers. This study uses a quasi-experimental comparative interrupted time series approach to examine a 90-min delay in start times in an urban district in North Carolina. Results show that the later start time resulted in more sleep for students and improved course grades but limited evidence of benefits to other educational outcomes. In addition, the evidence suggests that disruptions from the change may temporarily decrease some educational outcomes, and that these disruption effects are concentrated among low-income students and students of color.