bluuebunny/crossref_metadata_2025 huggingface dataset:
Making sense of self-reported practice impacts after online dementia education: the example of Bedtime to Breakfast and Beyond
Authors: Goodenough Belinda , Watts Jacqueline , Bartlett Sarah ,   the Dementia Training Australia Consortium
Published: November 2020

Objectives:

To satisfy requirements for continuing professional education, workforce demand for access to large-scale continuous professional education and micro-credential-style online courses is increasing. This study examined the Knowledge Translation (KT) outcomes for a short (2 h) online course about support at night for people living with dementia (Bedtime to Breakfast), delivered at a national scale by the Dementia Training Australia (DTA).

Methods:

A sample of the first cohort of course completers was re-contacted after 3 months to complete a KT follow-up feedback survey (n = 161). In addition to potential practice impacts in three domains (Conceptual, Instrumental, Persuasive), respondents rated the level of Perceived Improvement in Quality of Care (PIQOC), using a positively packed global rating scale.

Results:

Overall, 93.8% of the respondents agreed that the course had made a difference to the support they had provided for people with dementia since the completion of the course. In addition to anticipated Conceptual impacts (e.g., change in knowledge), a range of Instrumental and Persuasive impacts were also reported, including workplace guidelines development and knowledge transfer to other staff. Tally counts for discrete KT outcomes were high (median 7/10) and explained 23% of the variance in PIQOC ratings.

Conclusions:

Online short courses delivered at a national scale are capable of supporting a range of translation-to-practice impacts, within the constraints of retrospective insight into personal practice change. Topics around self-assessed knowledge-to-practice and the value of positively packed rating scales for increasing variance in respondent feedback are discussed.
Temporal and Age-Specific Trends in Acute Stroke Incidence: A 15-Year Population-Based Study of Administrative Data in Ontario, Canada
Authors: Joundi Raed A. , Smith Eric E. , Yu Amy Y.X. , Rashid Mohammed , Fang Jiming , Kapral Moira K.
Published: November 2020

Background:

Contemporary data on temporal trends in acute stroke incidence, specific to stroke type and age, are lacking. We sought to evaluate temporal trends in incidence of ischemic stroke and intracerebral hemorrhage over 15 years in a large population.

Methods:

We used linked administrative data to identify all emergency department visits and hospital admissions for first-ever ischemic stroke or intracerebral hemorrhage in Ontario, Canada from 2003–2017. We evaluated annual age-/sex-standardized incidence per 100,000 person-years for ischemic stroke and intracerebral hemorrhage across the study period. We used negative binomial regression to determine incidence rate ratios for each year compared to 2003, with assessment of modification by age, sex, or stroke type.

Results:

Our cohort had 163,574 people with stroke (88% ischemic stroke). For ischemic stroke and intracerebral hemorrhage combined, age-/sex-standardized incidence decreased between 2003 and 2011 (standardized rate 109.4 to 85.8 per 100,000; 22%), then increased until 2017 (standardized rate 96.8 per 100,000; 13%). The pattern of change was similar for ischemic stroke and intracerebral hemorrhage, and for men and women, but was modified by age. For those aged 60 and above, adjusted incidence rate ratios decreased from 2003 to 2011 then subsequently increased, whereas for those aged <60 years incidence rate ratios increased throughout the entire study time period, particularly after 2011.

Conclusions:

Acute stroke incidence decreased from 2003 to 2011 but subsequently increased until 2017. Among those aged <60, incidence increased continuously from 2003 to 2017 but especially after 2011. The underlying reasons for these changes should be determined.
Household Emergency Preparedness Instrument Development: A Delphi Study
Authors: Heagele Tara N. , McNeill Charleen C. , Adams Lavonne M. , Alfred Danita M.
Published: November 2020

Objective:

The main objective of this research was to generate a consensus on the conceptual definition of household emergency preparedness from experts representing multiple disciplines and countries, in order to facilitate the development of an all-hazards, comprehensive, valid, and reliable instrument.

Methods:

Questions were generated via 3 methods: literature search, using existing instruments, and expert panels using the Delphi technique.

Results:

Panelists (n = 154) representing 36 countries came to a consensus that household emergency preparedness is defined as the completion of several preparedness actions and assembling a kit that can be transported in an evacuation. The new 51-question instrument demonstrates face, content, and criterion validity and internal consistency reliability (α = 0.96). The instrument assesses whether specific preparedness actions have been taken, and the presence or absence of essential supplies that could enable households to safely endure conditions that disasters would likely present (loss of power, water limitations, and/or lack of access to additional supplies for a few days).

Conclusion:

A valid and reliable instrument provides researchers with a replicable approach to assessment of preparedness levels, which is necessary to plan mitigation strategies, enhance health promotion, prevent injuries, and increase resilience for individuals and communities. The instrument can provide evidence to support interventions addressing health needs of community members following a disaster.
Noncommutative strong maximals and almost uniform convergence in several directions
Authors: Conde-Alonso José M. , González-Pérez Adrián M. , Parcet Javier
Published: November 2020

Our first result is a noncommutative form of the Jessen-Marcinkiewicz-Zygmund theorem for the maximal limit of multiparametric martingales or ergodic means. It implies bilateral almost uniform convergence (a noncommutative analogue of almost everywhere convergence) with initial data in the expected Orlicz spaces. A key ingredient is the introduction of the$L_p$-norm of the$\limsup $of a sequence of operators as a localized version of a$\ell _\infty /c_0$-valued$L_p$-space. In particular, our main result gives a strong$L_1$-estimate for the$\limsup $—as opposed to the usual weak$L_{1,\infty }$-estimate for the$\mathop {\mathrm {sup}}\limits $—with interesting consequences for the free group algebra.

Let$\mathcal{L} \mathbf{F} _2$denote the free group algebra with$2$generators, and consider the free Poisson semigroup generated by the usual length function. It is an open problem to determine the largest class inside$L_1(\mathcal{L} \mathbf{F} _2)$for which the free Poisson semigroup converges to the initial data. Currently, the best known result is$L \log ^2 L(\mathcal{L} \mathbf{F} _2)$. We improve this result by adding to it the operators in$L_1(\mathcal{L} \mathbf{F} _2)$spanned by words without signs changes. Contrary to other related results in the literature, this set grows exponentially with length. The proof relies on our estimates for the noncommutative$\limsup $together with new transference techniques.

We also establish a noncommutative form of Córdoba/Feffermann/Guzmán inequality for the strong maximal: more precisely, a weak$(\Phi ,\Phi )$inequality—as opposed to weak$(\Phi ,1)$—for noncommutative multiparametric martingales and$\Phi (s) = s (1 + \log _+ s)^{2 + \varepsilon }$. This logarithmic power is an$\varepsilon $-perturbation of the expected optimal one. The proof combines a refinement of Cuculescu’s construction with a quantum probabilistic interpretation of M. de Guzmán’s original argument. The commutative form of our argument gives the simplest known proof of this classical inequality. A few interesting consequences are derived for Cuculescu’s projections.
The impact of coronavirus disease 2019 (COVID-19) response on central-line–associated bloodstream infections and blood culture contamination rates at a tertiary-care center in the Greater Detroit area
Authors: LeRose Jennifer , Sandhu Avnish , Polistico Jordan , Ellsworth Joe , Cranis Mara , Jabbo Lavina , Cullen Lori , Moshos Judy , Samavati Lobelia , Chopra Teena
Published: November 2020

We conducted a comparative retrospective study to quantify the impact of coronavirus disease 2019 (COVID-19) on patient safety. We found a statistically significant increase in central-line–associated bloodstream infections and blood culture contamination rates during the pandemic. Increased length of stay and mortality were also observed during the COVID-19 pandemic.
Economic signals of ethnicity and voting in Africa: analysis of the correlation between agricultural subsectors and ethnicity in Kenya
Authors: Kyung Kim Eun
Published: November 2020

The existing literature has demonstrated that both ethnic and economic factors affect a vote decision in African democracies. I show that there is a meaningful interaction between the two cleavages in their influence on voting. In particular, I argue for political salience of agricultural subsectors that shape the electoral consequences of economic performance in the context where agricultural policy affects the livelihood of the majority population. Relying on the analyses of the 2007 and 2013 elections in Kenya, I illustrate how likely an individual, who is attached to a politically coherent ethnic group, votes for a candidate, the majority of whose ethnic members engage in the same industry as the voter himself regardless of the candidate's ethnicity. The results show that the sector factor reinforces the positive and negative effects of ethnic communities on incumbent support, and also explains voting by ethnic minorities whose motives for voting are not ethnic.
Effects of first intermediate host density, host size and salinity on trematode infections in mussels of the south-western Baltic Sea
Authors: Bommarito Claudia , Thieltges David W. , Pansch Christian , Barboza Francisco R. , Pranovi Fabio , Wahl Martin
Published: November 2020

Trematode prevalence and abundance in hosts are known to be affected by biotic drivers as well as by abiotic drivers. In this study, we used the unique salinity gradient found in the south-western Baltic Sea to: (i) investigate patterns of trematode infections in the first intermediate host, the periwinkle Littorina littorea and in the downstream host, the mussel Mytilus edulis, along a regional salinity gradient (from 13 to 22) and (ii) evaluate the effects of first intermediate host (periwinkle) density, host size and salinity on trematode infections in mussels. Two species dominated the trematode community, Renicola roscovita and Himasthla elongata. Salinity, mussel size and density of infected periwinkles were significantly correlated with R. roscovita, and salinity and density correlated with H. elongata abundance. These results suggest that salinity, first intermediate host density and host size play an important role in determining infection levels in mussels, with salinity being the main major driver. Under expected global change scenarios, the predicted freshening of the Baltic Sea might lead to reduced trematode transmission, which may be further enhanced by a potential decrease in periwinkle density and mussel size.
Philippe Pinel and the foundations of modern psychiatric nosology
Authors: Kendler Kenneth S.
Published: November 2020

Philippe Pinel (1745–1826) played a major role in the foundation of modern psychiatric nosology. Much of his contribution, historically contextualized within the enlightenment generally and post-Revolutionary France more specifically, can be summarized through five themes in his background, education and writings. First, he applied an inductive, enlightenment-informed natural science approach to classification adapted from the biological sciences, which he had studied, and applied this to large samples of mentally ill individuals in Parisian asylums, frequently referring to ‘varieties’ and ‘species’ of insanity. Second, Pinel's classificatory approach rejected metaphysical and highly speculative etiologic theories in favor of a Baconian inductive approach utilizing observational data. Third, Pinel advocated repeated assessments of patients over time, feasible given long in-patient stays. Fourth, trained in philosophy, Pinel relied on philosophically informed models of the mind and of insanity. Fifth, Pinel extensively utilized faculty psychology to understand and classify mental illness. He anticipated further developments of nineteenth-century psychiatric nosology by challenging the then-dominant intellectualist models of insanity, adopting a humanistic-informed emphasis on the importance of symptoms alongside signs, arguing that passions could be the primary cause of mental illness, and trying to infer causal inter-relationships in psychiatric patients between disturbances in affect and understanding.
The impact of childhood trauma on thalamic functional connectivity in patients with obsessive–compulsive disorder
Authors: Chu Minyi , Xu Tingting , Wang Yi , Wang Pei , Gu Qiumeng , Liu Qiang , Cheung Eric F. C. , Chan Raymond C. K. , Wang Zhen
Published: November 2020

Background

Childhood trauma is a vulnerability factor for the development of obsessive–compulsive disorder (OCD). Empirical findings suggest that trauma-related alterations in brain networks, especially in thalamus-related regions, have been observed in OCD patients. However, the relationship between childhood trauma and thalamic connectivity in patients with OCD remains unclear. The present study aimed to examine the impact of childhood trauma on thalamic functional connectivity in OCD patients.

Methods

Magnetic resonance imaging resting-state scans were acquired in 79 patients with OCD, including 22 patients with a high level of childhood trauma (OCD_HCT), 57 patients with a low level of childhood trauma (OCD_LCT) and 47 healthy controls. Seven thalamic subdivisions were chosen as regions of interest (ROIs) to examine the group difference in thalamic ROIs and whole-brain resting-state functional connectivity (rsFC).

Results

We found significantly decreased caudate-thalamic rsFC in OCD patients as a whole group and also in OCD_LCT patients, compared with healthy controls. However, OCD_HCT patients exhibited increased thalamic rsFC with the prefrontal cortex when compared with both OCD_LCT patients and healthy controls.

Conclusions

Taken together, OCD patients with high and low levels of childhood trauma exhibit different pathological alterations in thalamic rsFC, suggesting that childhood trauma may be a predisposing factor for some OCD patients.
Migrant protection regimes: Beyond advocacy and towards exit in Thailand
Authors: Vigneswaran Darshan
Published: November 2020

International migrants are subject to many types of violence, such as trafficking, detention, and forced labour. We need an improved understanding of what protects migrants from such violence. The concept of ‘migrant protection regimes’ draws our attention away from formal rights advocacy and to both the informal dimensions of protection and the way migrants help determine the quality of protection they receive. ‘Migrant protection regimes’ are sets of rules and practices regarding who ought to protect whom. These regimes include formal rights to protection in the law and informal relationships that protect migrants from lawful violence by the state. They may be changed by ‘power grabs’, when sovereign actors seek to monopolise protection relationships, but also by ‘exits’, when migrants refuse to accept the protection on offer. The study demonstrates the value of these concepts by using them to explain an unlikely case: a change in laws concerning migrant protection in an authoritarian state: Thailand. Drawing on rich qualitative sources, the article reveals how, after a human rights advocacy campaign had placed migrants’ protection in jeopardy, a mass migrant exodus compelled the country's junta to offer migrants protection on better terms.
PRICING FORMULA FOR EXCHANGE OPTION BASED ON STOCHASTIC DELAY DIFFERENTIAL EQUATION WITH JUMPS
Authors: Kim Kyong-Hui , Kim Jong-Kuk , Jo Ho-Bom
Published: November 2020

This paper deals with pricing formulae for a European call option and an exchange option in the case where underlying asset price processes are represented by stochastic delay differential equations with jumps (hereafter “SDDEJ”). We introduce a new model in which Poisson jumps are added in stochastic delay differential equations to capture behaviors of an underlying asset process more precisely. We derive explicit pricing formulae for the European call option and the exchange option by proving a Lemma on the conditional expectation. Finally, we show that our “SDDEJ” model is meaningful through some numerical experiments and discussions.
All the News That’s Fit to Fabricate: AI-Generated Text as a Tool of Media Misinformation
Authors: Kreps Sarah , McCain R. Miles , Brundage Miles
Published: November 2020

Online misinformation has become a constant; only the way actors create and distribute that information is changing. Advances in artificial intelligence (AI) such as GPT-2 mean that actors can now synthetically generate text in ways that mimic the style and substance of human-created news stories. We carried out three original experiments to study whether these AI-generated texts are credible and can influence opinions on foreign policy. The first evaluated human perceptions of AI-generated text relative to an original story. The second investigated the interaction between partisanship and AI-generated news. The third examined the distributions of perceived credibility across different AI model sizes. We find that individuals are largely incapable of distinguishing between AI- and human-generated text; partisanship affects the perceived credibility of the story; and exposure to the text does little to change individuals’ policy views. The findings have important implications in understanding AI in online misinformation campaigns.
Können Zwang und Gewalt wirksam reduziert werden?
Authors: Sauter Dorothea , Walter Gernot , Mayer Michael , Kampmann Marie , Steinert Tilman
Published: November 2020

Zusammenfassung. 2018 wurde die S3-Leitlinie „Verhinderung von Zwang: Prävention und Therapie aggressiven Verhaltens bei Erwachsenen“ durch die Deutsche Gesellschaft für Psychiatrie, Psychotherapie, Psychosomatik und Nervenheilkunde (DGPPN) veröffentlicht (DGPPN, 2019). Obwohl Leitlinien eine wissenschaftlich fundierte klinische Orientierungshilfe bieten, bleibt ihr Durchdringungsgrad in der Praxis nicht selten gering. Oft sind sie den Fachpersonen nicht einmal bekannt. Deshalb wurden für diese Leitlinie zwölf konkrete Handlungsempfehlungen für psychiatrische Stationsteams abgeleitet. Siehe dazu den vorausgehenden Beitrag (Sauter, Walter, Mayer & Steinert, 2020).
Active Sediment Generation on Coral Reef Flats Contributes to Recent Reef Island Expansion
Authors: Ford M. R. , Kench P. S. , Owen S. D. , Hua Q.
Published: November 2020

The ongoing development of Jeh Island in the Marshall Islands was investigated using aerial photographs, high‐resolution satellite imagery, and radiometric dating of island sediments. Remote sensing observations show the present‐day island of Jeh is the product of two or more smaller islands merging together between 1943 and 2006 which are continuing to expand despite local sea‐level rise (SLR). Remote sensing observations show modern island development involving a complex multistage merging of smaller islands on a linear atoll rim. Radiometric ages of sediments demonstrate that island development is occurring through the active generation and delivery of modern sediments. Results highlight that at sites where sediment production regimes are in a healthy state, island building under conditions of SLR is possible. The findings have implications for interpreting island evolution from morphostratigraphic studies and understanding future island behavior with further SLR.
Observation and Simulation of the Development of Equatorial Plasma Bubbles: Post‐Sunset Rise or Upwelling Growth?
Authors: Chou Min‐Yang , Pedatella N. M. , Wu Qian , Huba J. D. , Lin Charles C. H. , Schreiner W. S. , Braun J. J. , Eastes R. W. , Yue Jia
Published: November 2020

This study investigates the underlying physics of equatorial plasma bubbles (EPBs) on 11 December 2019, under solar minimum conditions. The Global‐scale Observations of the Limb and Disk (GOLD) ultraviolet nightglow images exhibit a periodic distribution of reduced emissions related to EPBs. Remarkably, FORMOSAT‐7/COSMIC‐2 (F7/C2) observes a significant altitudinal difference of ~45 km in the bottomside ionosphere between two nearly collocated electron density profiles before the onset of EPBs, indicating the presence of an upwelling. Distinct ionospheric perturbations are also observed in F7/C2 and ground‐based Global Positioning System observations, suggesting that gravity waves may contribute to the upwelling. Simulations with SAMI3/ESF are further carried out to evaluate the upwelling growth and pre‐reversal enhancement (PRE) effect on EPB development. Simulations reveal that the crests of upwellings show a localized uplift of ~50 km, and EPBs only develop from the crest of upwellings. The uplift altitude of upwellings is comparable to the F7/C2 observations and the post‐sunset rise in moderate solar conditions. The polarization electric field (Ep) developed within the upwellings can drive vertical Ep × B drifts of ~32–35 m/s, which are comparable to the PRE vertical E × B drifts. We find that the PRE alone cannot drive EPBs without upwelling growth, but it can facilitate the upwelling growth. Observations and simulations allow us to conclude that upwelling growth could play a vital role in the formation of EPBs.
Barrier Layers in a High‐Resolution Model in the Eastern Tropical Pacific
Authors: Bingham F. M. , Li Z. , Katsura S. , Sprintall J.
Published: November 2020

This study examines salinity barrier layers (BLs) in the eastern tropical North Pacific in the region of the Salinity Processes in the Upper ocean Regional Studies‐2 field campaign. We utilize a high‐resolution numerical model to study BLs and their relationship to frontal features and small‐scale ocean variability, focusing on two specific events. One is associated with a large outbreak of BL presence near 7°N along 125°W. The other is a relatively isolated but persistent BL that forms near 13°N, again along 125°W. In both cases we find that the BL is proximate to a salinity frontal feature in which isohalines tilt toward the fresh side of the front at its base. The BLs studied are associated with divergent flow at the surface on the fresh side of the front and convergent flow on the salty side. Tilting of the front is invoked to explain this, with an additional mechanism involving a vertical circulation which causes the base of the front to tilt preferentially.
What Martian Meteorites Reveal About the Interior and Surface of Mars
Authors: Udry A. , Howarth G. H. , Herd C. D. K. , Day J. M. D. , Lapen T. J. , Filiberto J.
Published: November 2020

Martian meteorites are the only direct samples from Mars, thus far. Currently, there are a total of 262 individual samples originating from at least 11 ejection events. Geochemical analyses, through techniques that are also used on terrestrial rocks, provide fundamental insights into the bulk composition, differentiation and evolution, mantle heterogeneity, and role of secondary processes, such as aqueous alteration and shock, on Mars. Martian meteorites display a wide range in mineralogy and chemistry, but are predominantly basaltic in composition. Over the past 6 years, the number of martian meteorites recovered has almost doubled allowing for studies that evaluate these meteorites as suites of igneous rocks. However, the martian meteorites represent a biased sampling of the surface of Mars with unknown ejection locations. The geology of Mars cannot be unraveled solely by analyzing these meteorites. Rocks analyzed by rovers on the surface of Mars are of distinct composition to the meteorites, highlighting the importance of Mars missions, especially sample return. The Mars 2020 Perseverance rover will collect and cache—for eventual return to Earth—over 30 diverse surface samples from Jezero crater. These returned samples will allow for Earth‐based state‐of‐the‐art analyses on diverse martian rocks with known field context. The complementary study of returned samples and meteorites will help to constrain the evolution of the martian interior and surface. Here, we review recent findings and advances in the study of martian meteorites and examine how returned samples would complement and enhance our knowledge of Mars.
Laboratory Study of the Cameron Bands, the First Negative Bands, and Fourth Positive Bands in the Middle Ultraviolet 180–280 nm by Electron Impact Upon CO
Authors: Lee Rena A. , Ajello Joseph M. , Malone Charles P. , Evans J. Scott , Veibell Victoir , Holsclaw Gregory M. , McClintock William E. , Hoskins Alan C. , Jain Sonal , Gérard Jean‐Claude , Schneider Nicholas M.
Published: November 2020

We have analyzed medium‐resolution (full width at half maximum, FWHM = 1.2 nm), Middle UltraViolet (MUV; 180–280 nm) laboratory emission spectra of carbon monoxide (CO) excited by electron impact at 15, 20, 40, 50, and 100 eV under single‐scattering conditions at 300 K. The MUV emission spectra at 100 eV contain the Cameron Bands (CB) CO(a 3Π → X 1Σ+), the fourth positive group (4PG) CO(A 1Π → X 1Σ+), and the first negative group (1NG) CO+(B 2Σ+ → X 2Σ) from direct excitation and cascading‐induced emission of an optically thin CO gas. We have determined vibrational intensities and emission cross sections for these systems, important for modeling UV observations of the atmospheres of Mars and Venus. We have also measured the CB “glow” profile about the electron beam of the long‐lived CO (a 3Π) state and determined its average metastable lifetime of 3 ± 1 ms. Optically allowed cascading from a host of triplet states has been found to be the dominant excitation process contributing to the CB emission cross section at 15 eV, most strongly by the d 3Δ and a' 3Σ+ electronic states. We normalized the CB emission cross section at 15 eV electron impact energy by multilinear regression (MLR) analysis to the blended 15 eV MUV spectrum over the spectral range of 180–280 nm, based on the 4PG emission cross section at 15 eV that we have previously measured (Ajello et al., 2019, https://doi.org/10.1029/2018ja026308). We find the CB total emission cross section at 15 eV to be 7.7 × 10−17 cm2.
MDMA-induced changes in within-network connectivity contradict the specificity of these alterations for the effects of serotonergic hallucinogens
Authors: Müller Felix , Holze Friederike , Dolder Patrick , Ley Laura , Vizeli Patrick , Soltermann Alain , Liechti Matthias E. , Borgwardt Stefan
Published: November 2020

It has been reported that serotonergic hallucinogens like lysergic acid diethylamide (LSD) induce decreases in functional connectivity within various resting-state networks. These alterations were seen as reflecting specific neuronal effects of hallucinogens and it was speculated that these shifts in connectivity underlie the characteristic subjective drug effects. In this study, we test the hypothesis that these alterations are not specific for hallucinogens but that they can be induced by monoaminergic stimulation using the non-hallucinogenic serotonin–norepinephrine–dopamine releasing agent 3,4-methylenedioxymethamphetamine (MDMA). In a randomized, placebo-controlled, double-blind, crossover design, 45 healthy participants underwent functional magnetic resonance imaging (fMRI) following oral administration of 125 mg MDMA. The networks under question were identified using independent component analysis (ICA) and were tested with regard to within-network connectivity. Results revealed decreased connectivity within two visual networks, the default mode network (DMN), and the sensorimotor network. These findings were almost identical to the results previously reported for hallucinogenic drugs. Therefore, our results suggest that monoaminergic substances can induce widespread changes in within-network connectivity in the absence of marked subjective drug effects. This contradicts the notion that these alterations can be regarded as specific for serotonergic hallucinogens. However, changes within the DMN might explain antidepressants effects of some of these substances.
What is the minimal dose for resistance exercise effectiveness in prostate cancer patients? Systematic review and meta-analysis on patient-reported outcomes
Authors: Lopez Pedro , Taaffe Dennis R. , Newton Robert U. , Buffart Laurien M. , Galvão Daniel A.
Published: November 2020

Background

Active treatments for prostate cancer are well known to result in several adverse effects such as fatigue, depression and anxiety symptoms, impacting the overall quality of life (QoL) and wellbeing of a considerable proportion of patients. Resistance-based exercise interventions have shown positive effects to reduce or mitigate these treatment-related side effects. However, the minimal dosage required to derive these benefits is unknown. We systematically reviewed the resistance training effects in prostate cancer patients to determine the minimal dosage regarding the exercise components (mode, duration, volume and intensity) on fatigue, QoL, depression and anxiety.

Methods

Using PRISMA guidelines, MEDLINE, CINAHL, EMBASE, SPORTDiscus and Web of Science databases were searched. Eligible randomised controlled trials examined prostate cancer patients undertaking resistance-based exercise programs during or following treatment. Meta-analysis was undertaken when more than three studies were included. Associations between resistance exercise components and its effects were tested by meta-regression analysis.

Results

Eighteen trials involving 1112 men with prostate cancer were included. Resistance-based exercise programs resulted in significant effects on fatigue (effect size = −0.3, 95% CI: −0.4 to −0.2, P < 0.001) and QoL (effect size = 0.2, 95% CI: 0.0 to 0.4, P = 0.018), with significant effects in specific questionnaires and domains of these outcomes. Resistance-based exercise effects on depression (effect size = −0.3, 95% CI: −0.7 to 0.0) and anxiety symptoms (effect size = −0.3, 95% CI: −0.5 to 0.0) were positive but not significant (P = 0.071 to 0.077). Meta-regression indicated no significant association between resistance exercise components with fatigue and QoL outcomes (P = 0.186–0.689).

Conclusions

Low volume resistance exercise undertaken at a moderate-to-high intensity is sufficient to achieve significant fatigue and QoL benefits for men with prostate cancer and also mitigate depression and anxiety symptoms. A lower resistance exercise dosage than usually prescribed may help enhance adherence by reducing exercise barriers.
Ecology and evolution of antimicrobial resistance in bacterial communities
Authors: Bottery Michael J , Pitchford Jonathan W , Friman Ville-Petri
Published: November 2020

Accumulating evidence suggests that the response of bacteria to antibiotics is significantly affected by the presence of other interacting microbes. These interactions are not typically accounted for when determining pathogen sensitivity to antibiotics. In this perspective, we argue that resistance and evolutionary responses to antibiotic treatments should not be considered only a trait of an individual bacteria species but also an emergent property of the microbial community in which pathogens are embedded. We outline how interspecies interactions can affect the responses of individual species and communities to antibiotic treatment, and how these responses could affect the strength of selection, potentially changing the trajectory of resistance evolution. Finally, we identify key areas of future research which will allow for a more complete understanding of antibiotic resistance in bacterial communities. We emphasise that acknowledging the ecological context, i.e. the interactions that occur between pathogens and within communities, could help the development of more efficient and effective antibiotic treatments.
Stem cell donor registry activities during the COVID-19 pandemic: a field report by DKMS
Authors: Mengling Thilo , Rall Gabi , Bernas Stefanie N. , Astreou Nadia , Bochert Sandra , Boelk Torben , Buk Deborah , Burkard Konstanze , Endert Dennis , Gnant Katrin , Hildebrand Sabine , Köksaldi Hatice , Petit Isabelle , Sauter Jürgen , Seitz Susanne , Stolze Julia , Weber Karin , Weber Maren , Lange Vinzenz , Pingel Julia , Platz Alexander , Schäfer Thomas , Schetelig Johannes , Wienand Edith , Geist Sirko , Neujahr Elke , Schmidt Alexander H.
Published: November 2020

The COVID-19 pandemic has serious implications also for patients with other diseases. Here, we describe the effects of the pandemic on unrelated hematopoietic stem cell donation and transplantation from the perspective of DKMS, a large international donor registry. Especially, we cover the development of PBSC and bone marrow collection figures, donor management including Health and Availability Check (HAC), transport and cryopreservation of stem cell products, donor recruitment and business continuity measures. The total number of stem cell products provided declined by around 15% during the crisis with a particularly strong decrease in bone marrow products. We modified donor management processes to ensure donor and product safety. HAC instead of confirmatory typing was helpful especially in countries with strict lockdowns. New transport modes were developed so that stem cell products could be safely delivered despite COVID-19-related travel restrictions. Cryopreservation of stem cell products became the new temporary standard during the pandemic to minimize risks related to transport logistics and donor availability. However, many products from unrelated donors will never be transfused. DKMS discontinued public offline donor recruitment, leading to a 40% decline in new donors during the crisis. Most DKMS employees worked from home to ensure business continuity during the crisis.
Involvement of FATP2-mediated tubular lipid metabolic reprogramming in renal fibrogenesis
Authors: Chen Yuting , Yan Qi , Lv Mengyue , Song Kaixin , Dai Yue , Huang Yi , Zhang Le , Zhang Cuntai , Gao Hongyu
Published: November 2020

Following a chronic insult, renal tubular epithelial cells (TECs) contribute to the development of kidney fibrosis through dysregulated lipid metabolism that lead to lipid accumulation and lipotoxicity. Intracellular lipid metabolism is tightly controlled by fatty acids (FAs) uptake, oxidation, lipogenesis, and lipolysis. Although it is widely accepted that impaired fatty acids oxidation (FAO) play a crucial role in renal fibrosis progression, other lipid metabolic pathways, especially FAs uptake, has not been investigated in fibrotic kidney. In this study, we aim to explore the potential mechanically role of FAs transporter in the pathogenesis of renal fibrosis. In the present study, the unbiased gene expression studies showed that fatty acid transporter 2 (FATP2) was one of the predominant expressed FAs transport in TECs and its expression was tightly associated with the decline of renal function. Treatment of unilateral ureteral obstruction (UUO) kidneys and TGF-β induced TECs with FATP2 inhibitor (FATP2i) lipofermata restored the FAO activities and alleviated fibrotic responses both in vivo and in vitro. Moreover, the expression of profibrotic cytokines including TGF-β, connective tissue growth factor (CTGF), fibroblast growth factor (FGF), and platelet-derived growth factor subunit B (PDGFB) were all decreased in FATP2i-treated UUO kidneys. Mechanically, FATP2i can effectively attenuate cell apoptosis and endoplasmic reticulum (ER) stress induced by TGF-β treatment in cultured TECs. Taking together, these findings reveal that FATP2 elicits a profibrotic response to renal interstitial fibrosis by inducing lipid metabolic reprogramming including abnormal FAs uptake and defective FAO in TECs.
A blinded, controlled trial of objective measurement in Parkinson’s disease
Authors: Woodrow Holly , Horne Malcolm K. , Fernando Chathurini V. , Kotschet Katya E. ,   Treat to Target Study Group, Bhattacharya Arup , Blaze Richard , Charmley Andrew , Cruse Belinda , Duma Stephen , Evans Andrew , Ghaly Mina , Giarola Blake , Halliday Amy J. , Kimber Thomas , Kumar Anand , Lehn Alexander , Lilley Kate , Ma Andrew , Mahant Neil , McModie Salar , Perera Manju , Tang Huiliang Melissa , Tillett John W. , Tisch Stephen , Winkel Antony , Wools Christine
Published: November 2020

Medical conditions with effective therapies are usually managed with objective measurement and therapeutic targets. Parkinson’s disease has effective therapies, but continuous objective measurement has only recently become available. This blinded, controlled study examined whether management of Parkinson’s disease was improved when clinical assessment and therapeutic decisions were aided by objective measurement. The primary endpoint was improvement in the Movement Disorder Society-United Parkinson’s Disease Rating Scale’s (MDS-UPDRS) Total Score. In one arm, objective measurement assisted doctors to alter therapy over successive visits until objective measurement scores were in target. Patients in the other arm were conventionally assessed and therapies were changed until judged optimal. There were 75 subjects in the objective measurement arm and 79 in the arm with conventional assessment and treatment. There were statistically significant improvements in the moderate clinically meaningful range in the MDS-UPDRS Total, III, IV scales in the arm using objective measurement, but not in the conventionally treated arm. These findings show that global motor and non-motor disability is improved when management of Parkinson’s disease is assisted by objective measurement.
A detailed open access model of the PubMed literature
Authors: Boyack Kevin W. , Smith Caleb , Klavans Richard
Published: November 2020

Portfolio analysis is a fundamental practice of organizational leadership and is a necessary precursor of strategic planning. Successful application requires a highly detailed model of research options. We have constructed a model, the first of its kind, that accurately characterizes these options for the biomedical literature. The model comprises over 18 million PubMed documents from 1996–2019. Document relatedness was measured using a hybrid citation analysis + text similarity approach. The resulting 606.6 million document-to-document links were used to create 28,743 document clusters and an associated visual map. Clusters are characterized using metadata (e.g., phrases, MeSH) and over 20 indicators (e.g., funding, patent activity). The map and cluster-level data are embedded in Tableau to provide an interactive model enabling in-depth exploration of a research portfolio. Two example usage cases are provided, one to identify specific research opportunities related to coronavirus, and the second to identify research strengths of a large cohort of African American and Native American researchers at the University of Michigan Medical School.
16 years of topographic surveys of rip-channelled high-energy meso-macrotidal sandy beach
Authors: Castelle Bruno , Bujan Stéphane , Marieu Vincent , Ferreira Sophie
Published: November 2020

Sandy beaches are highly dynamic environments buffering shores from storm waves and providing outstanding recreational services. Long-term beach monitoring programs are critical to test and improve shoreline, beach morphodynamics and storm impact models. However, these programs are relatively rare and mostly restricted to microtidal alongshore-uniform beaches. The present 16-year dataset contains 326 digital elevation models and their over 1.635 × 106 individual sand level measurements at the high-energy meso-macrotidal rip-channelled Truc Vert beach, southwest France. Monthly to bimonthly topographic surveys, which coverage progressively extended from 300 m to over 2000 m to describe the alongshore-variable changes, are completed by daily topographic surveys acquired during a 5-week field campaign. The dataset captures daily beach response at the scale of a storm to three large cycles of interannual variability, through the impact of the most energetic winter since at least 75 years and prominent seasonal erosion/recovery cycles. The data set is supplemented with high-frequency time series of offshore wave and astronomical tide data to facilitate its future use in beach research.
Effect of UV-A, UV-B and UV-C irradiation of glyphosate on photolysis and mitigation of aquatic toxicity
Authors: Papagiannaki Dimitra , Medana Claudio , Binetti Rita , Calza Paola , Roslev Peter
Published: November 2020

The active herbicide ingredient glyphosate [N-(phosphonomethyl)glycine] is frequently detected as a contaminant in groundwater and surface waters. This study investigated effects of UV-A (365 nm), UV-B (302 nm) and UV-C (254 nm) irradiation of glyphosate in water on photolysis and toxicity to aquatic organisms from different trophic levels. A test battery with bacteria (Bacillus subtilis, Aliivibrio fischeri), a green microalga (Raphidocelis subcapitata), and a crustacean (Daphnia magna) was used to assess biological effect of glyphosate and bioactive transformation products before and after UV irradiation (4.7–70 J/cm2). UV-C irradiation at 20 J/cm2 resulted in a 2–23-fold decrease in toxicity of glyphosate to aquatic test organisms. UV-B irradiation at 70 J/cm2 caused a twofold decrease whereas UV-A did not affect glyphosate toxicity at doses ≤ 70 J/cm2. UV-C irradiation of glyphosate in drinking water and groundwater with naturally occurring organic and inorganic constituents showed comparable or greater reduction in toxicity compared to irradiation in deionized water. High-resolution mass spectrometry analyses of samples after UV-C irradiation showed > 90% decreases in glyphosate concentrations and the presence of multiple transformation products. The study suggests that UV mediated indirect photolysis can decrease concentrations of glyphosate and generate less toxic products with decreased overall toxicity to aquatic organisms.
Comparing supervised and unsupervised approaches to emotion categorization in the human brain, body, and subjective experience
Authors: Azari Bahar , Westlin Christiana , Satpute Ajay B. , Hutchinson J. Benjamin , Kragel Philip A. , Hoemann Katie , Khan Zulqarnain , Wormwood Jolie B. , Quigley Karen S. , Erdogmus Deniz , Dy Jennifer , Brooks Dana H. , Barrett Lisa Feldman
Published: November 2020

Machine learning methods provide powerful tools to map physical measurements to scientific categories. But are such methods suitable for discovering the ground truth about psychological categories? We use the science of emotion as a test case to explore this question. In studies of emotion, researchers use supervised classifiers, guided by emotion labels, to attempt to discover biomarkers in the brain or body for the corresponding emotion categories. This practice relies on the assumption that the labels refer to objective categories that can be discovered. Here, we critically examine this approach across three distinct datasets collected during emotional episodes—measuring the human brain, body, and subjective experience—and compare supervised classification solutions with those from unsupervised clustering in which no labels are assigned to the data. We conclude with a set of recommendations to guide researchers towards meaningful, data-driven discoveries in the science of emotion and beyond.
Hyperbolic mapping of human proximity networks
Authors: Rodríguez-Flores Marco A. , Papadopoulos Fragkiskos
Published: November 2020

Human proximity networks are temporal networks representing the close-range proximity among humans in a physical space. They have been extensively studied in the past 15 years as they are critical for understanding the spreading of diseases and information among humans. Here we address the problem of mapping human proximity networks into hyperbolic spaces. Each snapshot of these networks is often very sparse, consisting of a small number of interacting (i.e., non-zero degree) nodes. Yet, we show that the time-aggregated representation of such systems over sufficiently large periods can be meaningfully embedded into the hyperbolic space, using methods developed for traditional (non-mobile) complex networks. We justify this compatibility theoretically and validate it experimentally. We produce hyperbolic maps of six different real systems, and show that the maps can be used to identify communities, facilitate efficient greedy routing on the temporal network, and predict future links with significant precision. Further, we show that epidemic arrival times are positively correlated with the hyperbolic distance from the infection sources in the maps. Thus, hyperbolic embedding could also provide a new perspective for understanding and predicting the behavior of epidemic spreading in human proximity systems.
Prevalence and associated factors of glaucoma in the Russian Ural Eye and Medical Study
Authors: Bikbov Mukharram M. , Gilmanshin Timur R. , Zainullin Rinat M. , Kazakbaeva Gyulli M. , Arslangareeva Inga I. , Panda-Jonas Songhomitra , Khikmatullin Renat I. , Aminev Said K. , Nuriev Ildar F. , Zaynetdinov Artur F. , Uzianbaeva Yulia V. , Nikitin Nikolay A. , Mukhamadieva Svetlana R. , Yakupova Dilya F. , Rakhimova Ellina M. , Rusakova Iulia A. , Bolshakova Natalia I. , Safiullina Kamila R. , Jonas Jost B.
Published: November 2020

To assess the prevalence and associated factors of glaucoma in a Russian population. The population-based Ural Eye and Medical Study included 5899 (mean age 59.0 ± 10.7 years; range 40–94 years). Glaucomatous optic neuropathy was diagnosed using International Society of Geographical and Epidemiological Ophthalmology (ISGEO) criteria. Among 5545 participants with assessable optic disc photographs, 246 individuals [4.4%; 95% confidence interval (CI) 3.9, 5.0] had glaucoma, with open-angle glaucoma (OAG) in 177 individuals (3.2%; 95% CI 2.7, 3.7) and angle-closure glaucoma (ACG) in 69 individuals (1.2; 95% CI 1.0, 1.5), with IOP > 21 mmHg in 79 (32.1%) patients, and with 80 (32.5%) patients on glaucoma therapy. Glaucoma prevalence increased from 3/485 (0.6%; 95% CI 0.0, 1.3) in the age group of 40–45 years to 33/165 (20.0%; 95% CI 13.8, 26.2) in the group aged 80 + years. Higher OAG prevalence correlated with older age [odds ratio (OR) 1.07; 95% CI 1.04, 1.09; P < 0.001], longer axial length (OR 1.36; 95% CI 1.17, 1.58; P < 0.001), higher intraocular pressure (IOP) (OR 1.18; 95% CI 1.13, 1.23; P < 0.001), higher stage of lens pseudoexfoliation (OR 1.26; 95% CI 1.08, 1.47; P = 0.004) and lower diastolic blood pressure (OR 0.98; 95% CI 0.96, 0.99; P = 0.035). Higher ACG prevalence correlated with older age (OR 1.07; 95% CI 1.03, 1.11; P < 0.001), narrower anterior chamber angle (OR 0.81; 95% CI 0.77, 0.86; P < 0.001), and higher IOP (OR 1.30; 95% CI 1.23, 1.38; P < 0.001). Glaucoma caused moderate to severe vision impairment (MSVI) in 9 (4.9%; 95% CI 1.8, 8.1) out of 184 individuals with MSVI (OAG, n = 7; ACG, n = 2), and blindness in one (9.1%) of 11 blind individuals. In this population from Russia, two thirds of glaucoma patients were not on therapy, and in two thirds of the glaucoma patients IOP was ≤ 21 mmHg. Otherwise, glaucoma prevalence, OAG-to-ACG ratio, and glaucoma associations did not differ markedly from Caucasian and East Asian populations.