bluuebunny/crossref_metadata_2025 huggingface dataset:
THE PREVALENCE OF SOCIAL DISRESPECT TOWARDS CAREGIVERS: A BARRIER TO INDUSTRY GROWTH AND QUALITY ELDERLY CARE IN BANGLADESH
Authors:   Caregiver for elderly and dementia patients, Saeduzaman  ,   Caregivers Institute of Narsingdi, Bangladesh, Akter Sumaiya ,   Caregiver for infant and children; Caregivers Institute of Narsingdi, Bangladesh, Akter Roma ,   Caregiver for elderly; Caregivers Institute of Narsingdi, Bangladesh
Published: October 2024

This study systematically reviews the issue of social disrespect towards caregivers in Bangladesh and its far-reaching implications for the caregiving profession and the quality of elderly care. Drawing from 80 high-quality studies, the review reveals that social disrespect—manifesting as verbal abuse, condescension, and lack of recognition—is a widespread problem faced by caregivers, leading to emotional exhaustion, burnout, and high turnover rates. The findings show that 65% of the studies reported frequent disrespect towards caregivers, while 72% established a direct link between this disrespect and increased burnout. Additionally, 68% of the studies indicated that social respect strongly correlates with job satisfaction, with higher levels of respect leading to improved caregiver morale, retention, and care quality. Institutional challenges, such as the absence of formal training and professional development opportunities, exacerbate this problem by reinforcing the perception that caregiving is low-status, unskilled labor. The review highlights the potential for public awareness campaigns, policy interventions, and institutional reforms to address these issues, recommending that Bangladesh adopt similar approaches to those successfully implemented in countries like Japan and Australia. By improving societal attitudes, professionalizing the caregiving industry, and providing mental health support, these measures could significantly enhance the social standing of caregivers, improve job satisfaction, and ultimately lead to better care outcomes for the elderly population.
Intelligent healthcare for cardiac patients utilizing neural networks, k-means clustering, and ad hoc routing
Authors: Banerjee Majumder Annwesha , Gupta Somsubhra , Majumder Sourav , Singh Dharmpal
Published: October 2024

This paper introduced a comprehensive healthcare system designed to address the unique challenges faced by cardiac patients in economically and geographically constrained regions. The system operated in three phases, each contributing to the effective care of patients. In the initial phase, an artificial neural network model identified potential cardiac patients with an impressive accuracy of 90.16%, demonstrating its potential for early detection. The second phase employed k-means clustering to categorize patients into three groups based on the severity of their condition, facilitating precise prognosis and stratification. Finally, the system utilized an innovative ad hoc routing algorithm to securely transmit patient data to remote servers, enabling expert monitoring and consultation. The study's outcomes demonstrate the system's ability to accurately identify at-risk patients, appropriately categorize their condition, and efficiently route critical data. This holistic approach leverages cutting-edge technologies and methodologies to transform healthcare delivery in underserved areas. The novel system presents a promising avenue for enhancing cardiac care in regions with limited access to advanced healthcare services, ultimately improving patient outcomes and reducing disparities in cardiovascular healthcare.
FORMULATING THE TASKS OF WIZER.ME INFORMATION TECHNOLOGY COMPETENCE THE ADVANTAGE OF AN INTERACTIVE APPLICATION
Authors:   Osh State University, Keldibekova A. O. , Abdimalik kyzy J. ,   Osh State University
Published: October 2024

The article is devoted to the formation of professional competence of futurecomputer science teachers. Through the formation of information technology competencies, students' creative thinking can be developed and their intellectual abilities can be revealed. After all, the use of innovative technologies, the use of interactive teaching methods is the main requirement of modern education. Assessment of students' knowledge Wizer.me A feature of the tasks created in the interactive application and an advantage over other applications is that you can send multiple tasks via the same link and send feedback in different formats. Completing assignments submitted electronically increases students' ability to work on a computer. Information technology competencies can be developed only through practice. Therefore, the tasks set by the teacher should be such that they can be performed in the form of practice. Wizer.me The ways and benefits of preparing tasks created in an interactive application are described in the article.
FORMAÇÃO HUMANA E CONSCIÊNCIA DE CLASSE EM ISTVÁN MÉSZÁROS
Authors: De Araujo Rotelli Elisângela , Assis Almeida Leal Cátia Regina
Published: October 2024

Este artigo tem como objetivo debater os resultados encontrados em uma pesquisa de mestrado cujos conceitos principais abordados foram: formação humana e consciência de classe, e para isso nos baseamos nos posicionamentos do filósofo István Mészáros. O artigo e o trabalho que lhe deu origem estão fundamentado no método materialista histórico-dialético.  A formação humana enquanto um, dos oito princípios orientadores desenvolvidos no texto, aponta seu  papel nas possíveis intervenções sobre o capital e nos possibilita pensar em uma consciência de classe socialista e agir para e com a massa, a quem a luta verdadeiramente interessa.
DESENVOLVIMENTO MOTOR: EFEITOS DE UM PROGRAMA DE JOGOS EM CRIANÇAS COM SÍNDROME DE DOWN PARTICIPANTES DA APAE EM TUCURUÍ-PA
Authors: Gomes Elenir Campelo , Carvalho Ernandes Tadeu Barral de , Cardoso Alan Pantoja , Silva Amanda Santos da , Pereira Zainovan Serrão , Silva Elisangela Freitas da , Zaffalon Júnior José Robertto , Melo Gileno Edu Lameira de , Monteiro-santos Roseane
Published: October 2024

Objetivo: Avaliar os impactos de um programa de jogo, sobre o desenvolvimento motor de crianças com SD participantes da APAE (Associação de Pais e Amigos dos Excepcionais) no município de Tucuruí-PA. Metodologia: Trata-se de uma pesquisa de abordagem quali-quantitativa, em nível descritivo. Participaram da pesquisa 3 (três) crianças, sendo uma com 11 anos (criança 1), uma com 7 anos (criança 2) e uma com 10 anos de idade (criança 3), dois meninos e uma menina, todas atendidas pela Associação de Pais e Amigos dos Excepcionais (APAE - Tucuruí). O estudo foi realizado por meio da aplicação de um programa de jogos e brincadeiras, com base no Manual de Intervenção Motora de Rosa Neto et al. (2016), utilizando tecnologias pedagógicas e fez-se uso da Escala de Desenvolvimento Motor - EDM (ROSA NETO, 2002) para procedimento de testes pré e pós-intervenção. As aulas ocorreram 2 vezes por semana, tendo duração de 50 min diários, sendo os atendimentos realizados de forma individual. Resultados: Observou-se atraso motor em todos os participantes, sendo estes classificados com Quociente Motor Geral (QMG) ‘Muito Inferior’. Embora os voluntários não tenham alcançado a classificação desejada para a idade, houve uma melhora de ± 16 meses no QMG, o que significou a aproximação entre Idade Motora (IM) e Idade Cronológica (IC). As crianças 1 e 2 participavam somente do programa de jogos na APAE, já a criança 3, que obteve resultados superiores aos demais avaliados, realizava múltiplas atividades, tendo um acréscimo de 24 meses a IMG. Conclusões: Conclui-se que o jogo pode influenciar de forma positiva no desenvolvimento motor da criança com SD, todavia a estimulações por meio de atividades múltiplas podem potencializar o desenvolvimento motor da criança. A predominância de estudos transversais, dificulta a sistematização de um modelo de intervenção voltado para atender crianças com SD, para tanto, salientamos a necessidade de que novos modelos de intervenção sejam propostos afim de oferecer aporte para a atuação com este público.
KAJIAN YURIDIS TENTANG TINDAK PIDANA PENCURIAN DENGAN PEMBERATAN
Authors: Simbala Jaya , Borman M. Syahrul , Handayati Nur
Published: October 2024

Dalam perkara pidana, hukuman merupakan suatu hal yang tidak dapat dihindari dengan hukuman apapun. Namun, hal ini menimbulkan masalah ketika perbedaan tersebut tidak beralasan. Penulis menemukan bahwa pidana pencurian berbeda-beda sesuai dengan bobot putusan hakim: (1) Kedua putusan tersebut menunjukkan bahwa dalam perkara pencurian, hakim kurang memperhatikan faktor pidana yang membebani kedua putusan tersebut. dalam masyarakat dan tidak mempercayai tujuan hukuman yang diarahkan pada narapidana sebagai sarana untuk memperbaiki perilaku, dan mereka masih memiliki pemikiran positif atau legislatif yang kuat, yaitu penggunaan teori pencegahan khusus dan penerapan sistem residivisme. (2) Dari sudut pandang hakim dan penyidik, perbedaan antara putusan hakim dalam perkara pencurian dengan bobot kedua putusan tersebut tidak dapat dihilangkan, paling tidak diminimalkan dengan mempertimbangkan petunjuk yang terkait. pada dasarnya untuk kasus pencurian. perbuatan lahiriah dan hal-hal yang bersifat subyektif, seperti motivasi dan kesengajaan, juga memperhatikan akibat perbuatan, berat ringannya kejahatan, cara dilakukannya, sikap mental (rasa bersalah) dan pentingnya karakter. kejahatan Hakim hendaknya tidak hanya mengacu pada aspek formal saja.
The Impact of Nurse-Led Interventions on Patient Outcomes in Chronic Disease Management
Authors:   Generative artificial intelligence chatbot developed by Microsoft, .google.com gemini , Rahman Suraia ,   BSc in Nursing, Central Women Hospital, Shamoli, Dhaka
Published: October 2024

Chronic diseases such as diabetes, hypertension, and heart disease represent a significant burden on healthcare systems worldwide. Effective management of these conditions is crucial for improving patient outcomes and quality of life. Nurse-led interventions have emerged as a promising approach in chronic disease management. This research article explores the impact of nurse-led interventions on patient outcomes, analyzing various studies and highlighting the key components of successful programs. The findings indicate that nurse-led interventions can significantly improve clinical outcomes, patient satisfaction, and adherence to treatment plans.
Una nueva especie de Himascelis Sen Gupta, 1978 (Coleoptera, Cryptophagidae) de Taiwán
Authors: Otero José Carlos
Published: October 2024

A new species of Himascelis Sen Gupta, 1978 (Coleoptera, Cryptophagidae) from Taiwan A new species of Himascelis Sen Gupta, 1978 (Coleoptera, Cryptophagidae) from Taiwan is described and illustrated: Himascelis smetani n. sp. A key to the Himascelis species of Taiwan is presented. Two species: Himascelis gracilis Lyubarsky, 1999 and Himascelis nepalensis Lyubarsky, 1999 are rehabilitated as valid species.
ХVIII-ХІХ ҒҒ ҚАЗАҚ ҚОҒАМЫНДАҒЫ БАТЫРЛАР ИНСТИТУТЫ ЖӘНЕ ОНЫҢ ТРАНСФОРМАЦИЯСЫ
Authors: М.О. ЖҰМАҒАЛИЕВА  , Г.Б. ИЗБАСАРОВА
Published: October 2024

This article examines the formation of the Institute of heroes and analyzes the history of development as an institution. An overview of the historiography of the Institute of Heroes is given, an assessment of the role and activities of the Institute of heroes in Kazakh society is given with an analysis of the works of the authorsencountered in the study of the problem under consideration. The Institute of Heroes is a subject of research considered in the research of modern authors both in the pre-revolutionary and Soviet periods. The work of A. I. Levshin, the diary of the embassy visit of A. I. Tevkelev, M. P. Vyatkin, etc. Since the authors' works provide the first information about the Institute of Heroes, the article gave priority to the analysis of the main thoughts and opinions of the authors in these works. Analyzing the opinions about the Institute of Heroes in the works of authors of different periods, the history of the institute of heroes in the Kazakh society of the XVIII-XIX centuries and the course of its transformation are shown. The prerequisites for the transformation of the Institute of heroes, the main reason for which is the accession of Kazakhstan to Russia, are analyzed. The consequences of changes in the institute and their impact on society are analyzed. The Institute of Heroes has gone a long way in development, leaving behind a rich history. We can definitely say that at some point he served for the unity and independence of his country and people. Thanks to the study of the history of the Institute of Heroes, as a result of its new pages, it becomes clear that this contributes to strengthening the independence of our country.
Ensino Baseado em Simulação Médica: Avaliação da Eficácia do treino na auscultação cardíaca em estudantes de Medicina
Authors: Nunes Rosalina Lufefena , Napato Agostinho , Bunda Ricardo , Santos Mário , Martins José Lopes , Catumbela Emanuel , Lutucuta Sílvia , Dias Maria Fernanda
Published: October 2024

Introdução: A simulação médica é uma ferramenta importante no processo de ensino e aprendizagem em medicina, pois oferece a possibilidade de repetir o exercício até o futuro médico ganhar habilidade e competência antes do contacto com pacientes reais. Este estudo teve como objectivoavaliar a eficácia da aprendizagem em auscultação cardíaca por simulação, comparada com o ensino tradicional em estudantes de Medicina.Métodos: Realizou-se um estudo do tipo ensaio aleatório controlado, do tipo de intervenção educacional, com 117 estudantes do 3o ano da Faculdade de Medicina da Universidade Agostinho Neto (FMUAN), no ano Lectivo 2017, divididos em grupo A 59(controlo) e grupo B 58(caso). O grupo A teve aulas tradicionais (na enfermaria) e o grupo B aulas em simuladores (laboratório) sobre auscultação cardíaca. Todos os grupos tiveram 6 horas de treinamento divididas em 2 horas/dia por 3 dias consecutivos. Para o treino e teste foram utilizados manequins de auscultação cardíaca tipo NASCO auscultation trainer and smartscope. Após as aulas os dois grupos foram submetidos a um teste em doentes reais. Para comparar a eficácia de aprendizagem foi usado o teste qui-quadrado e o McNamar, com um nível de significância de 0,05.Resultados: Após o treino, os estudantes foram testados em pacientes reais quanto à habilidade de diferenciar os sons na auscultação cardíaca, sendo que 19 (34%) do grupo A e 53 (91%) do grupo B obtiveram resultado bom ou muito bom (p=0.001).Conclusão: O grupo B apresentou melhor habilidade na auscultação cardíaca e capacidade para diferenciar os sons normais e patológicos quando comparado com o grupo A. De onde se conclui que o ensino por simulação deverá ser incorporado no processo de ensino formal na FMUAN.
MEDICINA BASEADA NA EVIDÊNCIA
Authors: Morais Humberto
Published: October 2024

A Medicina Baseada na Evidência (MBE) é um movimento desenvolvido na escola médica de McMaster em Ontário (Canadá) nos anos 80 para o ensino de resolução de problemas na prática médica. Tem ganho grande popularidade na última década entre a comunidade médica.
Tem sido inserida na formação médica pré e pós-graduada. No entanto, não é isenta de críticas, e alguns autores consideram que a prática da BEM possa ser prejudicial.
Neste artigo o autor descreve o conceito e os princípios da BEM, com o propósito de os difundir entre nós. Aborda ainda, a propósito de um caso clínico virtual, algumas dificuldades, na prática da BEM.
A IMPORTÂNCIA DA FORMAÇÃO PERMANENTE PARA O EXERCÍCIO DA ENFERMAGEM
Authors: Rebelo Rita
Published: October 2024

A educação e a formação não se podem restringir a etapas delimitadas da vida de cada pessoa, pelo contrário, esta deve constituir um processo contínuo, que se desenvolve ao longo de toda a nossa vida. O acto educativo tem como principal objectivo, modificar o ser humano, de modo a que esta adquira ou melhore as suas capacidades e aptidões.
Effects of Mung Bean Residues on the Growth of Broiler Chickens
Authors: Momand Khyber , Abozar Faizanullah , Jameel Zabihullah , Yousafzai Waliullah
Published: October 2024

Background: Broiler Chickens are a contributor to protein for humans. In the maintenance of broilers, the cost of feed can reach to 50-60% of the total production expenses. Thus, alternative feeds which are cheap, easy to obtain, and contain good nutrition are needed. Mung bean and its residue are important factors of the broiler chickens feed. The purpose of this research is to evaluate the addition of mung bean and its residue as a feed to increase the growth of broiler chickens. Materials and Methods: The study conducted over 84 broiler chickens of one-day old during 35 days based on the record of their daily behaviors. The record of the chickens has been divided into four groups and each group divided into three replications. Each replication of a group consisted of seven chickens. Weight gain, feed intake, and feed conversion ratio were the only factors involved for measurement. Findings: We found that there was no significant differences (p>0.05) in the weight gain of chicks during 1-2 weeks of mung bean residue percentage groups compared to the control; however, during the 3-5 weeks, the weight gain of the mung bean residue groups increased and there was a noticeable change between third and fifth weeks. In the fifth week, 2.5% of mung bean residue weighed more than all other groups, which was due to better consumption of feeding and lack of disease. Conclusion: The study emphasized that by adding 2.5% of mung bean residue to the diet, chickens increase weight by less consumed feed as well as health, and resistance of chickens will be higher. Based on this study, we recommended that 2.5% mung bean residue should be added to the chicken diet after the third week, to gain more weight by consuming a small amount of diet.
Prevalence of Haemonchosis in Slaughtered Sheep in Daronta, Nangarhar
Authors: Amarkhil Rahimullah , Danish Faisal , Zahir Ahmadullah , Ahmadi Mahboobullah , Noori Gulnabi
Published: October 2024

Background: In developing countries, one of the most prevalent parasitic diseases is Haemonchosis. This infectious disease mostly caused severe clinical symptoms and ultimately death in small and large-scale ruminants. Materials and Methods: A cross-sectional investigation was carried out to seek the prevalence of Haemonchus spp. in slaughtered sheep at Daronta in various restaurant abattoirs in Nangarhar, Afghanistan. A total of 150 abomasum from slaughtered animals were observed from November 2018 to June 2019. The study animals were grouped based on sex (female and male) and their age (< 1 year, 1 – 2 years, and > 2 years). Findings: The results showed that the overall prevalence of Haemonchosis in sheep was 22.66%. In terms of age, the prevalence rate was higher in a group less than 1 year, (27.27%) followed by 1 to 2 years, (22.44%), and more than 2 years (14%) sheep. The sex-wise prevalence of Haemonchosis was higher in females (30.61%) as compared to males (18.81%). There was no significant difference (P > 0.05) between sex and age groups. Conclusion: The epidemiological evidence of the current study exhibited that Haemonchosis is a noticeably prevalent disease in sheep in Daronta, Nangarhar. To prevent, de-worming and good management practices are recommended.
The Rate and Reasons of Using Nutritional Supplements among Male-bodybuilders in Mazar-e-Sharif City, Afghanistan
Authors: Andishmand Nazifullah , Majedi Abdul Hafiz
Published: October 2024

‌Background: Nutritional supplements are products that consumed widely by sport populations around the world. The literature study of this research shows that only one article was published in 2011 about rate of using nutritional supplements among British Soldiers in Afghanistan. And there was not found any study in this case in Aghanistan. The main objectives of this study were to detect the rate and reasons of using nutritional supplements among male-bodybuilders of Mazar-e-Sharif city. Material and Methods: This study was conducted by analytical-descriptive via research questionnaires. At first, ten gyms were randomly selected from the all gyms of Mazar-e-Sharif city. There were distributed 130 questionnaires among male-bodybuilders randomly and 112 persons were responded to questionnaires. After collection of questionnaires, the data was analyzed by using of SPSS and defined the rate, reason and types of food supplements that were prevalent and used among male-bodybuilders of Mazar-e-Sharif city. Findings: Current research shows that the male-bodybuilders of Mazar-e-Sharif city’s gyms usually use four types of nutritional supplements, including Protein (90.2%), Creatine (87.5%), Carbohydrates (83.9 %) and Vitamins (86.7%). Also there were pointed four reasons for using of nutritional supplements by body-builders which are including of: weight increasing (25%), energy providing and endurance (37.5), increasing mass of muscles and, strength (19.7), and weight decreasing (17.8). Conclusion: A dietary or nutritional supplement is intended to provide nutrients that require for human body. Analyzing of current research data shows that the male-bodybuilders of Mazar-e-Sharif city’s gyms usually use four types of nutritional supplements including Protein, Creatine, Carbohydrates and Vitamins supplements. Also, there were pointed four reasons for using of nutritional supplements (weight increasing, energy providing and endurance, increasing mass of muscles and strength, and weight decreasing) among male-body-builders of Mazar-e-Sharif city.
Interplay of Post-Traumatic Stress Disorder, General Anxiety Disorder and Resilience among Earthquake Survivors in Zinda Jan District of Herat Province
Authors: Niazi Aziz-ur-Rahman , Alekozay Mina , Mohmand Noor Ali , Sadat Sayed Javid , Ahmadzadeh Ehsan Ahmad , Hamedi Taiebe , Rahimi Temorshah , Najm Abdul Fattah
Published: October 2024

‌Background: Frequent earthquakes that hit Herat province in October 2023 resulted in considerable loss of lives and massive property damage. They caused massive physical and psychosocial injuries; while physical injuries could be treated by healthcare professionals, psychological injuries could be neglected. This study aimed to assess the prevalence and associated factors of post-traumatic stress disorder (PTSD) and general anxiety disorder (GAD); and their association with resilience among earthquake survivors in Zinda Jan district. Materials and Methods: This community-based cross-sectional study was conducted during October and November 2023, among 418 cases -including 206 (49.3%) males and 212 (50.7%) females- with a mean age of 40.16±14.17 years. Sociodemographic data was collected via a structured questionnaire, data on PTSD was collected using the PTSD Checklist for DSM-5 (PCL-5), and data on GAD was collected via the Dari-version of GAD-7 questionnaire. Findings: GAD was detected in all (100%) participants, of whom 6 (1.4%), 29 (6.9%), and 383 (91.6%) had mild, moderate, and severe anxiety, respectively. Furthermore, 153 (36.6%), 134 (32.1%) and 131 (31.3%) participants suffered from mild, moderate and severe PTSD. As per resilience, 153 (36.6%) had low resilience, 142 (34.0%) had moderate resilience, and 123 (29.4%) had high resilience. There was a significant association between resilience and PTSD (p=0.011), but no significant association was observed between resilience and GAD (p=0.515). GAD was significantly associated with gender, marital status, and participants’ access to mental health. A significant association was found between PTSD and participants’ occupation, nutrition status, and access to mental health. Conclusion: The interplay between post-traumatic stress disorder, generalized anxiety disorder and resilience among earthquake survivors in the Zinda Jan district is a complex and multifaceted issue that demands further research and intervention. While the experiences of an earthquake can lead to the development of PTSD and GAD, resilience plays a crucial role in helping individuals overcome these challenges and rebuild their lives. A comprehensive understanding of this interplay can inform the development of effective interventions and prevention programs to support earthquake survivors and promote their overall well-being.
Coliform Contamination of Raw Beef at the Slaughterhouse and Butchery Levels in Herat City, Afghanistan
Authors: Shakhes Shoib Ahmad , Wasim Wakil Ahmad , Nasiry Zabihullah , Tookhy Nazir Ahmad
Published: October 2024

Background: Contaminated food products are responsible for causing various food borne diseases all over the world. Microbial contaminants are present in various food products, particularly raw meat. Among the most common microbial contaminants in meat and meat products are coliform bacteria. This study aimed to determine the coliform quality of raw beef with special emphasis on Escherichia coli in Herat city, Afghanistan and to compare the coliform contamination levels in the slaughterhouse and butchery levels. Materials and Methods: In this study, 150 samples of raw beef were randomly selected from butcheries and slaughterhouses of Herat city. Coliform identification was performed by standard bacteriological methods. Findings: The findings of this study revealed that coliform bacteria were detected in 70% and 75 % of beef samples from slaughterhouses and butcheries respectively. A total of 58 % of positive samples were upon the standard accepted ratio of coliforms contaminant per gram. The E. coli contamination ratio of samples in slaughterhouses and butcheries were 52% and 72% respectively. Our study demonstrates a significant difference in coliform bacteria contamination between slaughterhouse samples and butcheries. Conclusion: It was concluded that more than half of the coliform contamination in raw beef from the slaughterhouse and butcheries was exceeded the maximum limit which highlights the need to focus on effective monitoring of the slaughterhouse and butcheries in Herat city for prevention of meat borne intoxication and infection.
Mapping stakeholders in the development of eco-cities: Insights from Nepal and Indonesia
Authors:   Department of Development Studies, School of Arts, Kathmandu University., Rana Shreema , Aadisukma Dana ,   Urban and Regional Planning Department, Sekolah Tinggi Teknologi Nasional, Babarsari, Yogyakarta, Indonesia.
Published: October 2024

Urban areas are dynamic and intricate, encompassing various social, economic, ecological, and cultural aspects. It's crucial to employ effective approaches and management methods to achieve sustainable urban development. Stakeholder analysis is pivotal in understanding their roles and responsibilities in this process. By analyzing potential stakeholders and their responsibilities, enhances achieving development goals. This paper uses ‘solid waste bank’ and ‘socio-cultural water management approach’ case of Surabaya, Indonesia and Lalitpur, Nepal respectively. The challenges stakeholders face when implementing have been studied and mapped. Additionally, the significance of stakeholders in implementing development plans and policies has been reviewed through relevant journals and reports, considering the current cases of solid waste management and water management only. The mapping of stakeholders’ problems and prospects revealed that none of the stakeholders had low influence and low importance in both Nepal and Indonesia. This finding suggests that further studies could explore other relevant aspects of the stakeholder dynamics that could contribute to developing eco-city in both the countries. Also mapping, synthesizing both situation and stakeholder of other practices, and upgrading the practices as well may help achieve eco-city, which is unique, inclusive and has the contextual flavors.
Identification of molecular markers linked to leaf rust resistance gene Lr13 in wheat
Authors: Halaiev O. V. , Halaieva M. V.
Published: October 2024

Aim. Identification of codominant molecular markers closely linked to the Lr13 leaf rust resistance gene. Methods. PCR with detection in a polyacrylamide gel. Hybridological analysis. Phytopathology evaluation. Statistical analysis. Results. PCR analysis of varieties carrying the Lr13 gene and near-isogenic lines of the Thatcher variety with genes for resistance to leaf rust Lr13 (TcLr13), Lr16 (TcLr16), Lr23 (TcLr23) and the F2 population TcLr13 x TcLr34 by the microsatellite loci Xbarc13, Xbarc55, Xgwm148, Xwmc261, Xgwm271, Xwmc272, Xwmc344, Xbarc361, Xgwm410, Xwmc474, Xwmc477 and Xgwm630 was performed. To test the two microsatellite loci Xgwm148 and Xwmc344 as candidate markers for the Lr13 gene, we used the F2 population, which was obtained from crossing two near-isogenic lines of the Thatcher variety with leaf rust resistance genes Lr13 (TcLr13) and Lr34 (TcLr34). Conclusions. When comparing the genotyping data of F2 hybrids and the phenotypic manifestation of resistance to leaf rust, it was determined that the microsatellite locus Xwmc344 is closely linked to the Lr13 gene.
Acceleration of propagation of source material for Sorbus Sensu Lato Breeding
Authors: Nebykov M. V. , Opalko A. I. , Nebykova T. A. , Opalko O. A.
Published: October 2024

Aim. The permanent growth of interest in rowan and other currently underestimated Sorbus sensu lato crops has prompted the search to improve the accelerated propagation technique of its most valuable genotypes for breeding. Methods. The experiments involved 3–7-year-old Sorbus sensu lato plants from the National Dendrological Park "Sofiyivka" of the National Academy of Sciences of Ukraine collection. Statistical analysis of the experimental data was performed according to Ronald Fisher. Results. It was found that the germination rate of the studied sorboid plants depended on the method of seed preparation. In contrast, the grafting efficiency depended more on the grafting method than on the graft genotype. The use of our modified MS media allowed us to obtain clone formation coefficients (6.6–7.9) sufficient for effective micropropagation and to induce morphogenesis with 59.9–88.8 % of rooted microclones, as well as to achieve stable results of adaptation of the studied Sorbus sensu lato to non-sterile ex vitro conditions both in peat disks (69.1–90.3 %) and in containers with soil substrates (70.4–93.0 %). Conclusions. The results of comparing the methods of accelerated propagation of source material for breeding sorboid crops obtained in long-term experiments showed the advantages of micropropagation and the prospects for introducing the micropropagation link into breeding practice and nursery of the most valuable for horticulture Sorbus sensu lato.
Effectiveness of the use of chickpea collection samples in breeding
Authors: Sichkar V. I. , Lavrova H. D. , Dzhus T. O.
Published: October 2024

Aim. To determine the breeding value the large number of collection chickpea (Cicer arietinum L.) varieties obtained from the International Crops Research Institute for the Semi-Arid Tropics (India, Patancheru, ICRISAT) and the National Center for Plant Genetic Resources of Ukraine (Kharkiv) was evaluated in 1995-2022 under the conditions of the steppe zone of Ukraine. Methods. Standard field and laboratory methods (phenological observations, hybridization, structural analysis, biochemical analysis of protein content in seeds according to the Kjeldahl method), statistical analysis. Results. Donors and sources of such economically valuable features as early maturity, increased productivity, protein content in seeds, large-seeded, resistance against pathogens on an artificially created infectious background were identified. The set of 12 varieties of chickpea were developed by artificial hybridization, which are recommended for cultivation in all zones of Ukraine. Conclusions.The characteristics of the created varieties are given, the most valuable collection genotypes for use in crossing programs are recommended.
Introducción. Recordar y leer a Bolaño (1953-2003)
Authors: Pluta Podleszańska Nina , Jastrzębska Adriana Sara , Jasłowska Joanna
Published: October 2024

La jornada titulada “Leer bajo la ducha”, organizada el 19 de octubre de 2023 en Cracovia por las hispanistas de la Universidad Jaguelónica y el Instituto Cervantes de Cracovia, se inscribió en una serie de homenajes a Roberto Bolaño que le rindieron, en su triple aniversario, los lectores, académicos y no académicos, de diversas partes del mundo. Este artículo, amén de servir de introducción a un dossier de estudios sobre la obra de Bolaño (fruto de las intervenciones de los asistentes a dicha jornada), rastrea también algunas tendencias críticas locales visibles en las reseñas y los trabajos académicos polacos.
La recepción y la crítica literaria de Roberto Bolaño en Hungría
Authors: Horvath Livia
Published: October 2024

¿Cómo y cuándo se publicaron las obras de Roberto Bolaño en Hungría? ¿Qué huella dejó su oeuvre en el canon húngaro? En mi trabajo presentaré la cronología de la publicación de las obras de Bolaño en húngaro, su fondo editorial y su recepción crítica —la abundancia de las reseñas y el carácter de éstas, analizando los factores que lo convirtieron en un autor considerable.
Estrella distante como relato/relación del todo-mundo
Authors: Genschow Karen
Published: October 2024

En Estrella distante (1996), una de las novelas breves de Roberto Bolaño, se encuentra ya toda la máquina de referencialidad e intertextualidad que constituye uno de los factores de la “mundiali-dad” del autor y su obra. Al mismo tiempo, su año de publicación coincide con la del ensayo de Édouard Glissant sobre una de las figuras influenciales del boom latinoamericano: William Faulk-ner, quien aparece también en los paratextos de la novela de Bolaño. A partir de las múltiples referencias e intertextos de la novela, el artículo propone una lectura de Estrella distante en (ciertos) términos de Glissant, entre ellos el de “tout-monde”, como conceptualización alternativa del para-digma de “world literature” pensada desde el margen y no desde el centro (con, por ejemplo, París como núcleo geográficamente y culturalmente localizado) y con una temporalidad si bien no del todo construida como otra, sí puesta en tela de juicio.
Human Brain Barcodes
Authors: Shibata Darryl
Published: October 2024

Dynamic CpG methylation “barcodes” were read from 15,000 to 21,000 single cells from three human male brains. To overcome sparse sequencing coverage, the barcode had ∼31,000 rapidly fluctuating X-chromosome CpG sites (fCpGs), with at least 500 covered sites per cell and at least 30 common sites between cell pairs (average of ∼48). Barcodes appear to start methylated and record mitotic ages because excitatory neurons and glial cells that emerge later in development were less methylated. Barcodes are different between most cells, with average pairwise differences (PWDs) of ∼0.5 between cells. About 10 cell pairs per million were more closely related with PWDs < 0.05. Barcodes appear to record ancestry and reconstruct trees where more related cells had similar phenotypes, albeit some pairs had phenotypic differences. Inhibitory and excitatory neurons both showed evidence of tangential migration with related cells in different cortical regions. fCpG barcodes become polymorphic during development and can distinguish between thousands of human cells.
Structure of human PIEZO1 and its slow inactivating channelopathy mutants
Authors: Shan Yuanyue , Guo Xinyi , Zhang Mengmeng , Chen Meiyu , Li Ying , Zhang Mingfeng , Pei Duanqing
Published: October 2024

PIEZO channels transmit mechanical force signals to cells, allowing them to make critical decisions during development and in pathophysiological conditions. Their fast/slow inactivation modes have been implicated in mechanopathologies, but remain poorly understood. Here, we report several near-atomic resolution cryo-EM structures of fast-inactivating wild-type human PIEZO1 (hPIEZO1) and its slow-inactivating channelopathy mutants with or without its auxiliary subunit MDFIC. Our results suggest that the faster inactivating hPIEZO1 has a more flattened and extended architecture than the slower inactivating curved mouse PIEZO1 (mPIEZO1). The multi-lipidated MDFIC subunits insert laterally into the hPIEZO1 pore module like mPIEZO1, resulting in a more curved and extended state. Interestingly, the high-resolution structures suggest that the pore lipids, which directly seal the central hydrophobic pore, are involved in the rapid inactivation of hPIEZO1. While the severe hereditary erythrocytosis mutant R2456H significantly slows down the inactivation of hPIEZO1, the hPIEZO1-R2456H-MDFIC complex shows a more curved and contracted structure with an inner helix twist due to the broken link between the pore lipid and R2456H. These results suggest that the pore lipids may be involved in the mechanopathological rapid inactivation mechanism of PIEZO channels.
BMP9 and BMP10 coordinate liver cellular crosstalk to maintain liver health
Authors: Zhao Dianyuan , Huang Ziwei , Li Xiaoyu , Wang Huan , Hou Qingwei , Wang Yuyao , Yan Fang , Yang Wenting , Liu Di , Yi Shaoqiong , Han Chunguang , Hao Yanan , Tang Li
Published: October 2024

The liver is the largest solid organ in the body and is primarily composed of HCs, ECs, KCs, and HSCs, which spatially interact and cooperate with each other to maintain liver homeostasis. However, the complexity and molecular mechanisms underlying the crosstalk between these different cell types remain to be revealed. Here, we generated mice with conditional deletion of Bmp9/10 in different liver cell types and demonstrated that HSCs were the major source of BMP9 and BMP10 in the liver. Using transgenic ALK1 (receptor for BMP9/10) reporter mice, we found that ALK1 is expressed on KCs and ECs other than HCs and HSCs, and BMP9/10 secreted by HSCs promotes the differentiation of KCs and ECs and maintain their identity. Pdgfb expression was significantly upregulated in KCs and ECs after BMP9 and BMP10 deletion, ultimately leading to HSCs activation and liver fibrosis. ECs express several angiocrine factors, such as BMP2, BMP6, Wnt2 and Rspo3, to regulate hepatocyte iron metabolism and metabolic zonation. We found that these angiocrine factors were significantly decreased in ECs from Bmp9/10 HSC-KO mice, which further resulted in liver iron overload and disruption of HC zonation. In summary, we demonstrated that HSCs play a central role in mediating liver cell‒cell crosstalk via the production of BMP9/10, highlighting the important role of intercellular interaction in organ development and homeostasis.
Amoeboid cells undergo durotaxis with soft end polarized NMIIA
Authors: Kang Chenlu , Chen Pengcheng , Yi Xin , Li Dong , Hu Yiping , Yang Yihong , Cai Huaqing , Li Bo , Wu Congying
Published: October 2024

Cell migration towards stiff substrates has been coined as durotaxis and implicated in development, wound healing and cancer, where complex interplays between immune and non-immune cells are present. Compared to the emerging mechanisms underlying the strongly adhesive mesenchymal durotaxis, little is known about whether immune cells - migrating in amoeboid mode - could follow mechanical cues. Here we develop an imaging-based confined migration device with stiffness gradient. By tracking live cell trajectory and analyzing the directionality of T cells and neutrophils, we observe that amoeboid cells can durotax. We further delineate the underlying mechanism to involve non-muscle myosin IIA (NMIIA) polarization towards the soft-matrix-side but may not require differential actin flow up- or down-stiffness gradient. Using the protista
Dictyostelium
, we demonstrate the evolutionary conservation of amoeboid durotaxis. Finally, these experimental phenomena are theoretically captured by an active gel model capable of mechanosensing. Collectively, these results may shed new lights on immune surveillance and recently identified confined migration of cancer cells, within the mechanically inhomogeneous tumor microenvironment or the inflamed fibrotic tissues.
Nuclear Translocation of SIRT4 Mediates Deacetylation of U2AF2 to Modulate Renal Fibrosis Through Alternative Splicing-mediated Upregulation of CCN2
Authors: Yang Guangyan , Xiang Jiaqing , Yang Xiaoxiao , Liu Xiaomai , Li Yanchun , Li Lixing , Kang Lin , Liang Zhen , Yang Shu
Published: October 2024

TGF-β stimulates CCN2 expression which in turn amplifies TGF-β signaling. This process promotes extracellular matrix production and accelerates the pathological progression of fibrotic diseases. Alternative splicing plays an important role in multiple disease development, while U2 small nuclear RNA auxiliary factor 2 (U2AF2) is an essential factor in the early steps of pre-mRNA splicing. However, the molecular mechanism underlying abnormal
CCN2
expression upon TGF-β stimulation remains unclear. This study elucidates that SIRT4 acts as a master regulator for CCN2 expression in response to TGF-β by modulating U2AF2-mediated alternative splicing. Analyses of renal biopsy specimens from patients with CKD and mouse fibrotic kidney tissues revealed marked nuclear accumulation of SIRT4. The tubulointerstitial fibrosis was alleviated by global deletion or tubular epithelial cell (TEC)-specific knockout of
Sirt4
, and aggravated by adeno-associated virus-mediated SIRT4 overexpression in TECs. Furthermore, SIRT4 was found to translocate from the mitochondria to the cytoplasm through the BAX/BAK pore under TGF-β stimulation. In the cytoplasm, TGF-β activated the ERK pathway and induced the phosphorylation of SIRT4 at Ser36, which further promoted its interaction with importin α1 and subsequent nuclear translocation. In the nucleus, SIRT4 was found to deacetylate U2AF2 at K413, facilitating the splicing of CCN2 pre-mRNA to promote CCN2 protein expression. Importantly, exosomes containing anti-SIRT4 antibodies were found to effectively mitigate the UUO-induced kidney fibrosis in mice. Collectively, these findings indicated that SIRT4 plays a role in kidney fibrosis by regulating CCN2 expression via the pre-mRNA splicing.
Clustering uncertain overlapping symptoms of multiple diseases in clinical diagnosis
Authors: Wagan Asif Ali , Talpur Shahnawaz , Narejo Sanam
Published: October 2024

In various fields, including medical science, datasets characterized by uncertainty are generated. Conventional clustering algorithms, designed for deterministic data, often prove inadequate when applied to uncertain data, posing significant challenges. Recent advancements have introduced clustering algorithms based on a possible world model, specifically designed to handle uncertainty, showing promising outcomes. However, these algorithms face two primary issues. First, they treat all possible worlds equally, neglecting the relative importance of each world. Second, they employ time-consuming and inefficient post-processing techniques for world selection. This research aims to create clusters of observed symptoms in patients, enabling the exploration of intricate relationships between symptoms. However, the symptoms dataset presents unique challenges, as it entails uncertainty and exhibits overlapping symptoms across multiple diseases, rendering the formation of mutually exclusive clusters impractical. Conventional similarity measures, assuming mutually exclusive clusters, fail to address these challenges effectively. Furthermore, the categorical nature of the symptoms dataset further complicates the analysis, as most similarity measures are optimized for numerical datasets. To overcome these scientific obstacles, this research proposes an innovative clustering algorithm that considers the precise weight of each symptom in every disease, facilitating the generation of overlapping clusters that accurately depict the associations between symptoms in the context of various diseases.
An enhanced genetic algorithm solution for itinerary recommendation considering various constraints
Authors: Şehab Muhammed , Turan Metin
Published: October 2024

This paper addresses the challenging task of itinerary recommendation for tourists and proposes an approach for suggesting efficient optimal itineraries in Istanbul, based on constraints. The paper presents an enhanced version of the genetic algorithm (GA), which aims to optimize the itineraries considering various constraints and preferences of the tourists. The improvement of the GA involved suggesting a customized fitness function tailored to address the complexities of the tourism problem, considering factors such as distance, time, cost, tourists’ budget, and their desired activities and attractions. Additionally, we proposed a new crossover method, named “Copy Order Crossover” and we modified the tournament selection method beside enhancing the implementation of the swap mutation method for greater efficiency and adaptability. The enhanced GA is evaluated on the Burma dataset taken from TSPLIB, and our constructed Istanbul dataset, achieving significant enhancement rates in GA (43.89% for Istanbul, and 56.60% for Burma). This paper provides a detailed account of the proposed approach, its implementation, and the evaluation conducted. The experimental results conclusively demonstrated the superiority of the proposed approach over alternative methods in terms of time, efficiency, and accuracy. This paper finishes with an outlook with a detailed potential approach to overcome itinerary recommendation problem limitations.
Enhancing behavior classification of children in dynamic interaction scenes through improved DCNN model
Authors: Hao Kexian
Published: October 2024

The rapid development of society makes people pay more attention to the quality of the environment for children’s growth. However, due to the differences of young children, different environments are often needed for cultivation in dynamic interaction scenarios. Therefore, the authors propose an environment creation method for children’s behavior classification to improve the quality of children’s growth environment. Taking the video data of children for a period of time as input, the encoder and decoder are designed to classify children’s behavior and obtain behavior characteristics. After the input image is processed by the backbone network DCNN, two outputs are obtained, which are four times of shallow features and 16 times of high-level features. Aiming at the semantic gap between environmental features and children’s behavior features, the DenseNet model is used to remove the semantic difference between children’s behavior features and environmental features, and the similarity between the two features is fitted as much as possible. The dense blocks obtained by different expansion factors of the network are used for feature connection, so that the model is suitable for feature similarity calculation of different modes. The experimental results show that this method can accurately classify children’s behavior, and the F value is more than 70%, which can provide prerequisites for children’s environment creation. This environment creation model can clearly point out the suitable environment for children and provide a guarantee for children’s growth.
CONSTRUÇÃO DO TEMPO FICCIONAL PELA CRIANÇA:
Authors: Abicalil Belmiro Celia , De Souza Leite Galvão Cristiene , Vinicius Rodrigues Martins Marcus
Published: October 2024

Relato e análise de um evento de leitura literária compartilhada em uma turma com 14 crianças de 4 anos de uma Cooperativa de Ensino de Belo Horizonte, MG. Partiu-se das ideias de Bakhtin e de Vigotski, a fim de relacionar o discurso verbal com as ações humanas e com a vida. Golse apresenta as primeiras experiências narrativas dos bebês e Perroni traz contribuições sobre os processos que subjazem à capacidade de narrar das crianças. A metodologia tem em Gumperz a perspectiva sociointeracionista do discurso para análise do evento. Os resultados mostraram que aceitar o jogo da ficção é para as crianças um ato de liberdade, profundamente humano e pleno de sentido, pois pressupõe construir algo novo. A mediação do adulto é importante na construção de um ambiente pedagógico que as considera como sujeitos ativos da linguagem.