bluuebunny/crossref_metadata_2025 huggingface dataset:
A herediter haemorrhagiás teleangiectasia (Osler–Weber–Rendu-kór) genetikai diagnosztikája
Authors: Major Tamás , Gindele Réka , Szabó Zsuzsanna , Jóni Natália , Kis Zsuzsanna , Bora László , Bárdossy Péter , Rácz Tamás , Karosi Tamás , Bereczky Zsuzsanna
Published: April 2019

Abstract:

Introduction: Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant multisystemic vascular disease with a worldwide prevalence of 1 : 5000 – 1 : 10 000. Diagnosis is based on clinical Curacao criteria. Approximately 85% of HHT cases have heterozygous family-specific mutations in the ENG or ACVRL1 genes. Aim: We investigated 23 Hungarian HHT families, established the genetic diagnosis, executed family-screening and confirmed founder effects. Method: Probands were identified by the stratified population screening of the primary attendance area of our institution and from individuals contacting our study group voluntarily. Diagnosis is based on the otorhinolaryngological physical examination completed with characteristic telangiectasis sites, a visceral arteriovenous malformation screening and the sequence analysis of ENG and ACVRL1 genes. The family screening consists of physical examination and genetic screening for the family-specific mutation, followed by the arteriovenous malformation screening in patients with definite/suspected HHT and/or in individuals with the mutation. Results: Sixty-three individuals with family-specific mutations were identified in 22 families, 48 of them with definite and 12 with suspected HHT. Seven ENG and ACVRL1 mutations were detected, respectively; most of these are pathogenic. Three founder mutations were observed. One proband with definite HHT had wild-type alleles in all tested HHT-specific loci. Conclusions: The significance of genetic testing is confirming or excluding HHT in young asymptomatic individuals in families with pathogenic mutations. As ENG and ACVRL1 mutations result in overlapping fenotypes, the genetic testing lacks any prognostic value. The identification of founder effects might simplify the genetic diagnosis of new HHT patients from a given region. Orv Hetil. 2019; 160(18): 710–719.
Penyusunan dan Pengembangan Alat Ukur Islamic Personality Scale (IPS)
Authors: Farmawati Cintami , Hidayati Nur
Published: April 2019

Islamic personality could be different with other personalities which cannot be explained completely by Western personality theory. For example, Western psychology might see the concept radicalism or suicide bombings as pathological, while in Islam, it is believed to be part of a behavior that reflects self-actualization. The aim of the research is to develop and develop instruments that can measure the Islamic Personality Scale (IPS) based on the theoretical framework of personality according to Islamic teachings and test the validity and reliability of this study. The research subjects were 550 students from three different universities who were selected by quota sampling. Data is obtained through testing of measuring instruments, internal validity and development of measuring instruments. Data is analyzed using Cronbach's Alpha and Confirmatory Factor Analysis. The results showed that the scale has high reliability. Islamic personality in the research subjects included ammarah, lawwamah, and mutmainah personality.
Advances in Religion, Cognitive Science, and Experimental Philosophy, edited by Helen De Cruz and Ryan Nichols
Authors: Kvandal Halvor
Published: April 2019

Advances in Religion, Cognitive Science, and Experimental Philosophy, edited by Helen De Cruz and Ryan Nichols, Bloomsbury, 2016. Advances in Experimental Philosophy series. 221pp. $42.95 USD ISBN: 978-1-47422- 382-9
Evelyn Underhill rozumienie mistyki
Authors: Kiwka Mirosław
Published: April 2019

W świecie anglojęzycznym I połowy XX wieku Evelyn Underhill (1875–1941) była jedną z najbardziej poczytnych autorek, piszących o religii i życiu duchowym, a szczególnie o mistyce chrześcijańskiej. Ukazanie zasadniczych elementów jej teorii mistyki stanowi zasadniczy cel niniejszego przedłożenia. Jego realizację otwiera przedstawienie wypracowanego przez nią pojęcia mistyki i jej zasadniczych charakterystyk. Omówienie etapów procesu mistycznego, problemu autentyczności oraz jedności doświadczenia mistycznego łącznie z kontekstem filozoficznym i strukturami antropologicznymi, które autorka wykorzystuje w swoich analizach – stanowi tematykę dalszej części opracowania. Całość zamyka niezwykle inspirująca wizja mistycznej przyszłości rodzaju ludzkiego, jaką znajdujemy w publikacjach tej anglikańskiej pisarki.
Wolność a łaska. Interpretacja problemu w filozofii Józefa Tischnera
Authors: Trombik Kamil
Published: April 2019

W artykule podjęto próbę rekonstrukcji poglądów Józefa Tischnera dotyczących zagadnienia relacji między łaską a wolnością człowieka. Omówiony został także filozoficzno-teologiczny kontekst, w ramach którego kształtowały się poglądy krakowskiego myśliciela. Wskazano również na najbardziej perspektywiczne wątki w Tischnerowskiej koncepcji łaski i wolności, które mogą okazać się inspirujące zarówno w obrębie dyscyplin filozoficznych, jak i teologicznych.
Przez wsparcie do jakości kształcenia. O sytuacji osób z niepełnosprawnościami w UPJPII w Krakowie
Authors: Bolińska Marta
Published: April 2019

Od kilku lat w Polsce zainteresowanie sytuacją osób niepełnosprawnych rośnie. Zmiany w szkolnictwie wyższym obejmują także kandydatów na studentów i studentów z niepełnosprawnością. O ile infrastruktura działa coraz lepiej, o tyle zarówno nauczyciele akademiccy, jak i administracja mają jeszcze wiele do zrobienia. Stopniowo zwiększa się jednak świadomość, że niepełnosprawność nie musi być ograniczeniem, także w dostępie do nauki na uczelni wyższej. Uniwersytety dążą do tego, aby studenci mieli jednakowe szanse na kształcenie i nie doświadczali ograniczeń w uczestniczeniu w życiu społeczności akademickiej np. z powodu niepełnosprawności.
Embassy of Prince Grigory Konstantinovich Volkonsky to the Crimea in 1614–1615
Authors: Vinogradov Alexander
Published: April 2019

Introduction. The author examines the insufficiently studied period of diplomatic communicationsof the Moscow Tsardom and the Crimean Khanate after Mikhail Fedorovich Romanov’s enthronement, which led to establishing relatively peaceful mutual relations between them at the final stage of military and political confrontation of Russia with the Polish-Lithuanian Commonwealth and the Swedish Crown.

Materials. The paper reveals the circumstances of establishing contractual relations between Moscow and Bakhchysarai on the basis of unpublished sources. The information from the columns of 1613–1614 about the stay of the embassy of A. Lodyzhensky and P. Danilov in the Crimea from autumn of 1613 to July 1614, the preparation and holding of the embassy congress and exchange of ambassadors at Livny in August 1614, the stay of the embassy of Prince G.K. Volkonsky and P. Ovdokimov in the Crimea in August 1614 – June 1615, the stay of Magmet Chelebi’s embassy in Moscow in September 1614 – March 1615 and, finally, the embassy exchange under Valuyki in July 1615 form a single set of documents that let us trace the course of diplomatic relations between the Moscow Tsardom and the Crimean Khanate in 1613–1615. The decisive stage in difficult and tense diplomatic negotiations of the parties in this period, in our opinion, is the stay of the embassy of Prince Grigory Konstantinovich Volkonsky and clerk Peter Ovdokimov in the Crimea.

Results. This article shows the role of relations with the Crimea in general foreign policy of the government of Tsar Mikhail Fedorovich and in the restoration of military and political control over the Lower Volga Region territory.
Applying Our Imagination to Settle Unfinished Business
Authors: Chang Mitchell J.
Published: April 2019

Recent events on colleges campuses specifically and society generally suggest that a new generation of scholars will inherit the unfinished business of resolving our nation’s longstanding “race problem.” What can a journal do to improve their chances of producing scholarship that will lead to dismantling oppressive racial patterns and order? I argue in this manuscript that JCSCORE should provide more space to exchange and critique imaginations of new racial meanings and structures. Such forward-looking thinking that stretch beyond standardized approaches to scholarship can help coordinate and guide the application of empirical research. After all, “social change” is much more than an empirical project and ultimately requires a creative and organizing vision that inspires, invents, and sustains transformative actions.
Sodium intercalation into α- and β-VOSO4
Authors: Deriouche W. , Anger E. , Amdouni N. , Pralong V.
Published: April 2019

Na-ion battery is one of the best alternatives to Li-ion battery. Abundance of sodium on earth is three orders of magnitude higher than lithium, which should make Na-ion battery technology cheaper. But alkaline-ion battery prices, which tend to increase because of the massive world demand, also depend on the choice of electrode materials. Therefore, cost-effective electrode development remains an important subject of research because this will allow Na-ion battery to be even more competitive. Electrochemical performances of anhydrous VOSO4 as electrode for Na-ion battery are reported in this letter. Two anhydrous phases of vanadyl sulfate have been studied. The first one, α-VOSO4, shows that up to 0.8 sodium per formula unit (Na/f.u.) can be intercalated in this phase, and a reversible intercalation of 0.4 Na/f.u. has been observed with a strong polarization. The second one, β-VOSO4, can intercalate up to 0.9 Na/f.u. with a reversible intercalation of 0.4 Na/f.u. leading to a reversible capacity of 64 mAh/g.
Administrative paradoxes and paroxysms of resource provision and development of the economy
Authors: Shuklina Zinaida
Published: April 2019

The article presents the author’s opinion on the ambiguity, instability and paradox of the management of resources, resource provision and resource potential. The importance of studying and understanding paradoxical phenomena is emphasized, the urgency of the entropy of civilizational changes, the problems of non-linear, turbulent development of the country, including from the standpoint of the use of resource potential and resource management, is highlighted. Economic paradoxes include the Paradoxes of Easterlin, Giffen, Bazermann, Veblen, Thaler, Coase, Retlisberger. In the system of paradoxes, a special place is occupied by the paradoxes of abundance, innovative development, technological deflation, innovative management of resources and potentials. The sharp politicization of international economic relations is manifested in the paradoxical consequences of globalization, informatization and the redistribution of the world in a period of turbulence and uncertainty. Paradoxes and paroxysms are an integral part of resource management and economics. Paradoxes are connected with the controversy surrounding the effect of the Dutch disease, the “paradox of abundance” or the “curse of resources”, according to which countries with significant natural resources are poorly developed in comparison with countries with small reserves of raw materials or their complete lack. The heightened perception of the problem actualizes the search for a mechanism to effectively manage the natural resource rent and ensure high results for the economic and social development of the country. At the level of management of national resources, a paradoxical situation persists when there is no disposal when owning resources, there is no proportional and fair distribution when selling and receiving surplus income, when the country’s resource wealth is not equated with the wealth and decent life of the people. All the problems of resource management are inextricably linked with the peculiarities of external collisions of world interaction, internal power structuring, cognitive and systematic thinking, ideals and ideologies of development, personalized, individualized transformations of the world. At different levels of systems thinking, technologies and management strategies emerge, change and develop, demanding scientific reinforcement in the ideological, ideological, and methodological direction.
Phase II Study of S-1 and Paclitaxel Combination Therapy in Patients with Previously Treated Non-Small Cell Lung Cancer
Authors: Chihara Yusuke , Yoshimura Akihiro , Date Koji , Takemura Yoshizumi , Tamiya Nobuyo , Kohno Yoshihito , Imabayashi Tatsuya , Takeuchi Mayumi , Kaneko Yoshiko , Yamada Tadaaki , Ueda Mikio , Arimoto Taichiro , Uchino Junji , Iwasaki Yoshinobu , Takayama Koichi
Published: April 2019

Lessons Learned

In terms of efficacy and safety, good results were obtained with S-1 and paclitaxel (PTX) combination therapy. The findings suggest that S-1 and PTX combination therapy is a feasible treatment option in patients with previously treated non-small cell lung cancer.

Background

Although monotherapy with cytotoxic agents, including docetaxel and pemetrexed, is recommended for patients with previously treated advanced non-small cell lung cancer (NSCLC), its outcomes are unsatisfactory. S-1 is an oral fluoropyrimidine agent that consists of tegafur, 5- chloro-2, 4-dihydroxypyridine, and potassium oxonate. S-1 is approved for patients with gastric cancer in 7 Asian countries and 15 European countries. It is also approved for patients with eight type of cancers, including NSCLC, in Japan. We evaluated the efficacy and toxicity of S-1 and paclitaxel (PTX) combination therapy in patients with previously treated NSCLC.

Methods

Oral S-1 was administered thrice weekly on days 1–14 at 80, 100, and 120 mg/day in patients with body surface areas of <1.25, 1.25–1.5, and >1.5 m2, respectively. PTX was administered at 80 mg/m2 on days 1 and 8. Primary endpoint was response rate, and secondary endpoints were progression-free survival (PFS), overall survival (OS), and safety.

Results

Forty patients were enrolled, with response and disease control rates of 27.5% and 75.0%, respectively (Fig. 1). Median PFS and OS were 6.5 and 20.7 months, respectively. Grade 3/4 anemia and thrombocytopenia were seen in five (12%) and one (2%) patients, respectively. Febrile neutropenia occurred in three patients (7%). Common grade 3/4 nonhematological toxicities were stomatitis (5% of patients), diarrhea (7% of patients), and interstitial lung disease (one patient). No treatment-related deaths were observed.

Conclusion

This S-1 and PTX cotherapy dose and schedule showed satisfactory efficacy, with mild toxicities, in patients with previously treated advanced NSCLC.
Effects of granular collisions on the rapid coarse-grained materials flow
Authors: Federico F. , Cesali C.
Published: April 2019

A continuum model to predict the mobility of landslides is developed according to the formulation by Savage and Hutter as well as the main ‘microscopic aspects’ affecting the rapid sliding of granular masses. Conservation of mass and momentum equations, describing the geometry and velocity evolution during the motion, are re-written by considering the effects of collisions between solid grains (‘granular temperature’ and ‘dispersive pressures’) typically occurring within a basal thin ‘shear’ layer, causing a ‘fluidification’ effect and corresponding energy dissipations. To this purpose, a ‘frictional−collisional’ rheological law allowing to simulate the energy dissipation related to grain inelastic collisions and friction, simultaneously acting within the basal ‘shear layer’, is developed and applied. The interstitial pressures, and their possible increment along curved paths related to centrifugal force, and the mass variation due to erosion/deposition processes are also considered. The numerical simulation of a documented experimental test is finally carried out.
Mitigation of ancient coal mining hazards to overhead line equipment structures
Authors: Haiderali Aliasger E.
Published: April 2019

Subsidence and collapse of structures supporting overhead line equipment (OLE) due to legacy coal mining can be catastrophic during both the construction and operational phases, causing damage to construction plant, injuries and fatalities to the construction and maintenance workforce, failure of the track and disruption to the operational railway. When applied to linear railway schemes spanning considerable distances, industry guidelines for appraising and mitigating these mining hazards are overly conservative with a disproportionate cost. On phase 4 of the North West Electrification Project between Manchester Victoria and Euxton Junction, an innovative risk-based method was devised and implemented to identify and mitigate mining hazards to OLE structures. Formulation of these value-engineering solutions prevented programme drift and led to significant cost savings. Details of this methodology, including a detailed desk study, computational geomechanics, a well-targeted ground investigation, void remediation and real-time foundation monitoring, are discussed in this paper.
Ana Dili Eğitimi Dergisinde Yayımlanan Makalelerin Bibliyometrik Analizi
Authors: KARAGÖZ Beytullah , KOÇ ARDIÇ İmran
Published: April 2019

Bilgi aktarımı ve paylaşımı sürecinde
alana özgü bilimsel dergilere büyük ihtiyaç bulunmaktadır. Ana Dili Eğitimi
Dergisi (ADED), Türkçe eğitimi alanındaki araştırmalara ev sahipliği yapan
hakemli bilimsel bir dergidir. Ana Dili Eğitimi Dergisi, 2013 yılından bu yana
kesintisiz olarak yayın hayatını sürdürmektedir. Dergi yılda dört sayı
olarak yayımlanmaktadır. Derginin tüm sayılarına Dergipark üzerinden açık
erişim politikasıyla ücretsiz olarak ulaşılabilmektedir. Bu çalışmada
2013-2018 yılları arasında Ana Dili Eğitimi Dergisinde yayımlanan makalelerin
bibliyometrik özellikler bakımından incelenmesi amaçlanmıştır. Dergide
yayımlanan makaleler bibliyometrik yaklaşımla incelenerek çeşitli açılardan
karşılaştırmalar yapılmış ve bazı sonuçlara ulaşılmıştır. Bu bağlamda Ana Dili
Eğitimi Dergisi toplam makale sayısı, makalelerin yayın dili, makalelerin sayfa
sayıları, makalelerin yazarlık durumları, yazarların çalıştıkları kurumlar,
yazarların unvanı, makalelerin değerlendirme süresi, makalelerdeki kaynak
türleri, makalelerdeki kaynakça sayılarının dağılımı, makalelerin konu dağılımı
açısından incelenmiştir. Araştırmanın bazı bulguları şunlardır: Dergide en çok
yayın yapılan akademik yayın türü makaledir. Makalelerin tamamına yakını
Türkçedir. Dergide en çok makale yayımlanan yıl 2018 (f=68) olmuştur. Makale
sayfa sayılarının %34’ü 16-20 sayfa aralığında yoğunlaşmaktadır. Dergideki
yayınlar çoğunlukla iki yazarlıdır. Dergiye katkı sağlayan yazarların çoğunluğu
“Dr. Öğr. Üyesi/Yrd. Doç. Dr.” unvanlıdır. Ana Dili Eğitimi Dergisine en çok
katkı yapan araştırmacılar Gazi Üniversitesi, Milli Eğitim Bakanlığı ve Mustafa
Kemal Üniversitesi adreslidir. Dergide en sık atıf yapılan kaynak türü, dergidir
(makale).
Digterlike beheer en herinterpretasie: T.T. Cloete se transkripsie van twee antieke tekste in Onversadig
Authors: Taljard M
Published: April 2019

Die doel van hierdie artikel is om twee gedigte uit die later werk van T.T. Cloete te ontleed met die oog daarop om sy siening van die "omvattende gedig" te demonstreer. Daar word aangetoon hoedat hierdie twee gedigte (wat eksemplaries is vir ŉ groot deel van die digterlike oeuvre) saamgestel is uit intertekstuele verwysings na die werk van talryke ander digters én na sy eie werk. Daar word hoofsaaklik eksemplaries te werk gegaan met die veronderstelling dat die gekose gedigte die kernaspekte van Cloete se poëtika verteenwoordig en in ŉ groot mate poëtiese gestalte gee aan gedagtes wat die skering en inslag vorm van sy selfrefleksiewe werk Die ander een is ek (2013). Die praktyk van jukstaposisie word as belangrike teoretiese basis gebruik. Daarbenewens word verskillende vorme van intertekstualiteit ondersoek. Laasgenoemde praktyk vind in die twee tersaaklike gedigte veral gestalte in woordelikse herskrywing of transkripsie. Die gevolgtrekking word gemaak dat die digter in die afdeling "saamsing", uit die bundel Onversadig ŉ kortbegrip van sy ars poëtika aanbied en dat hy nie net lig werp op sy digterlike praktyk nie, maar dat hy ook sy eie identiteit as digter en geskende mens in die gedigte "saamsing" en "Achilles se skild" inskryf.
Die invloed van agenthebbende passiefkonstruksies op die veranderende gebruik van die setsel deur
Authors: Kotzé I , Kirsten J
Published: April 2019

Daar is min deskriptiewe navorsing beskikbaar oor die gebruik van setsels in Afrikaans. Die meerderheid van die literatuur fokus op wat presies setsels is en hoe setsels in konstruksies gebruik word, sonder om veel aandag te skenk aan die grammatikale funksie daarvan in sodanige konstruksies. Diachroniese navorsing oor setsels is ook beperk en die diachroniese navorsing wat wel beskikbaar is, fokus nie op die veranderende gebruik van setsels nie. ŉ Setsel waaroor daar min navorsing beskikbaar is, is deur. In hierdie artikel word ondersoek ingestel na die veranderende gebruik van die setsel deur vir die periode 1911 tot 2010. Die setsel se prominentste en ander meer of minder algemene gebruike word aan die hand van funksionele sintaksis, spesifiek die voorstellingsfunksie, geïdentifiseer met behulp van korttermyn-diachroniese korpuslinguistiese metodes. Elke afdeling van die korpus verteenwoordig ŉ dekade van Afrikaanse taalgebruik, naamlik 1911-1920 (A1), 1941-1950 (A2), 1971-1980 (A3) en 2001-2010 (A4). Die analises toon dat die belangrikste algehele frekwensieveranderinge wat deur ondergaan het, ten nouste verweef is met die gebruik van deur-setselstukke om akteurs in agenthebbende passiefkonstruksies in te lei. Tussen A1 en A2 van die korpus is daar ŉ beduidende toename in die algehele gebruik van setselstukke met deur, gevolg deur ŉ beduidende afname in gebruik tussen A2 en A4. Ongeveer 47% van al die setselstukke met deur word oor die korpus heen gebruik om die akteur van agenthebbende passiewe konkrete prosesse in te lei. Die prominentste gebruik van deur het waarskynlik verander as gevolg van ŉ verandering in die totale passiefgebruik oor die korpus heen. Die veranderende setselgebruik van deur kan gevolglik nie toegeskryf word aan verandering in die gebruik van die setsel op sigself nie, maar dit is eerder indirek die resultaat van die veranderende gebruik van passiefkonstruksies oor die korpus heen.
Onderwysers se persepsies oor die moontlike impak van die afwesige vader op kinderontwikkeling
Authors: Botha L , Meyer L
Published: April 2019

Vaderafwesigheid is ŉ ernstige probleem in Suid-Afrika (Ratele et al. 2012:553). Statistieke toon dat daar ongeveer nege miljoen kinders in Suid-Afrika sonder ŉ vader grootword (Statistics South Africa [StatsSA] 2015). Dit toon ook die stelselmatige verdwyning van tradisionele gesinstrukture aan. Die belangrikheid van die verskillende rolle wat die vader in ŉ kind se lewe speel, word deur navorsing beklemtoon. Sy betrokkenheid in die gesin lei tot ŉ gesonde kinder- en volwasse lewe ten opsigte van psigologiese en gedragsdimensies (Choi & Jackson 2011:698-704; Flouri & Buchanan 2003:63-78; Ratele et al. 2012:553). Volgens Saliha en Jayan (2013:40) is ŉ goeie vader van kardinale belang vir die optimale ontwikkeling van ŉ kind. In die lig van bogenoemde is ŉ gevallestudie geloods om die persepsies van onderwysers oor die moontlike impak van vaderafwesigheid op kinderontwikkeling te ondersoek.
Die invloed van ŉ intervensieprogram op Graad R-opvoeders se ervaring ten opsigte van professionele ontwikkeling in spelgebaseerde geletterdheid
Authors: Veldsman A , van Heerden J
Published: April 2019

Hierdie studie ondersoek die invloed van ŉ intervensieprogram op Graad R-opvoeders se ervaring van hul professionele ontwikkeling. ŉ Intervensieprogram is saamgestel op grond van basislyndata omtrent deelnemers se voorkennis van spelgebaseerde geletterdheid, die deelnemers se vrese en bekommernisse omtrent die volg van ŉ spelgebaseerde benadering vir Graad R-leerders, asook die deelnemers se behoefte betreffende die onderrig van spelgebaseerde geletterdheid. Die intervensieprogram is voorts deur middel van deelnemende aksienavorsing ontwerp. Aangesien die intervensieprogram op die professionele ontwikkeling van opvoeders fokus, is daar van drie modelle as teoretiese raamwerke gebruik gemaak. Die CRASP I- en CRASP II-modelle fokus op die professionele ontwikkeling van opvoeders, terwyl die bekommernissegebaseerde model van onderwysersopleiding opvoeders bewus maak van moontlike vrese en bekommernisse ten opsigte van hul onderrig en hulle dan help om hierdie vrese te oorkom. Empiriese data is deur middel van kwalitatiewe data-insamelingsmetodes gegenereer. Die metodes het navorsingsrefleksiejoernale van die deelnemers en die navorser, samewerkende besprekings, semigestruktureerde fokusgroeponderhoude, observasie, oopeindevrae en oopeinde-onderhoude ingesluit. Die bevindinge van die studie dui daarop dat die deelnemers die intervensieprogram baie positief beleef het. Die bevindinge dui verder daarop dat die deelnemers na afloop van die intervensieprogramme meer insig in leerders se agterstande asook insig in hul eie onderrigmetodes gekry het. Die deelnemers aan die studie se selfvertroue in die benutting van spelgebaseerde onderrig het verbeter sodat hulle meer doelgerig kon onderrig en beplan. Die deelnemers het verder daarop gewys dat hul kennis in so ŉ mate verbeter het dat hulle leerders met uitdagings beter kan identifiseer en dienooreenkomstig kan ondersteun. Die studie, bevindinge en aanbevelings kan ŉ bydrae lewer tot die professionele ontwikkeling van opvoeders betreffende die onderrig van spelgebaseerde geletterdheid.
Dekolonisering van die kurrikulum: ŉ Kontekstualisering van Ekonomie- en Besigheidstudie-onderrig
Authors: America C , America L
Published: April 2019

Die debat oor die dekolonisering van opvoeding het (her)opgeduik in Suid-Afrika. Daar word erken dat dekolonisering ŉ komplekse en veelvlakkige proses is met betrekking tot die betekenis, wie behoort in Afrika-universiteite te onderrig, wat behoort onderrig te word vir watter student (SU 2017). Komplekse begrippe soos Afrikanisasie, Eurosentrisme, verwestersing, kolonialisme, kolonialiteit, dekolonisering en dekolonialiteit het verskyn en is belig (sien SU 2017; Le Grange 2016; Le Grange 2018; Mbembe 2015). Daar is egter ŉ swye in huidige diskoerse wanneer dit kom by onderwysersopleiding (Sayed, Motala, & Hoffman 2017), spesifiek betreffende die onderrig van Ekonomie en Besigheidstudie (EBSO). Dit is omdat die dekoloniseringsdebat merendeels op hoër onderrig in die algemeen gefokus is (sien Le Grange 2016; Le Grange 2018; Mtembe 2015). Die vraag is hoe die EBSO-kurrikulum as deel van ŉ aanvanklike onderwysersopleidingsprogram gedekoloniseer en die kontekstuele en inhoudskennis belyn kan word. Inhoudskennis in EBSO is gemodelleer op ŉ oorwegend neoklassieke wêreldsiening wat meestal ontdaan is van plaaslike Suid-Afrikaanse sosio-ekonomiese werklikhede (America 2014; Maistry & David 2018) en waar ongelykheid en armoede in die samelewing steeds aansienlik hoog is (Bernstein 2014; Wêreldbank 2018). Die pre- en postkoloniale tydperke het voetspore gelaat in die hedendaagse ongelykheid en ŉ disposisie wat diep gewortel is in instellings en organisasies. Die hedendaagse sakewêreld en ekonomie waarin instellings en organisasies gevestig is, vorm deel van die inhoud van EBSO, maar is nie noodwendig 'n aanduiding van die kontekstuele kennis nie. Die rol van instellings word later bespreek. Ons argumenteer dat insig in die volgende drie aspekte riglyne kan verskaf vir die belyning van kontekstuele met inhoudskennis in onderwysersopleiding: die meriete van geskiedenis, die stel van kritiese vrae en die modellering van gekontekstualiseerde onderrig. Die toepassing van kennis wat relevant is vir spesifiek (Suid-)Afrikaanse kontekste kan studente in staat stel om beter sin te maak van hul vakgebied. Voorafgaande impliseer ŉ tweeledige aanpassing in die EBSO-kurrikulum: eerstens die insluiting van Afrika-perspektiewe en tweedens die integrasie van ekonomie en besigheidsgeskiedenis in die kurrikulum.
Staining conditions for murine IHC v1
Authors: Anderson Kristin
Published: April 2019

Staining conditions for murine IHC.
Onomastics, Medicine and Politics in Femi Osofisan’s The Engagement
Authors: Ojebode Ayokunmi O. , Odebode Idowu O.
Published: April 2019

Onomastics, medicine and politics in this study are a pragmatic way of depicting the psychosocial condition of Nigeria as an underdeveloped nation. The study explores Femi Osofisan’s The Engagement from a literary onomastic standpoint with the aim of exposing socio-political anomalies in Nigeria. Nigerian leaders commit flaws of egoistical and individualistic interests which often go against the consciences of the led. On this premise, the study explores the characters’ names in The Engagement with a view to gaining insight into Nigeria’s sociocultural and political contexts. Furthermore, Postcolonial Theory and Halliday’s Contextual Theory of Meaning serve as the study’s theoretical constructs. The study is predicated on the underdevelopment of Nigeria which is epitomised as a psychological behaviour of characters in a nation that is under the siege of political anarchy and different social vices.
Curriculum Designs: Top-down or Bottom-up? —A Case Study in a Technological School of China
Authors: Li Hui
Published: April 2019

Competitive education around the world brings up many issues about curriculum design. In order to cultivate the ideal talents with abundant knowledge of language and specialties, it is necessary to design appropriate curricula. This comparative study has been carried out to discuss the appropriateness of curriculum designed for two parallel groups of English learners as a foreign language based on the survey in a technological school, a case study in China. In this special issue, curriculum design is likely to be problematic although it made a little improvement compared to the one before 2010: a) an analogical curriculum has been designed for both groups of students; b) what directions a curriculum design should follow, the more the better? c) how to balance a national curriculum, its localization and its implementation? d) top-down and bottom-up, language and specialty, which matters? This paper eventually puts forwards some suggestions which would be helpful for the future curriculum design.
On the Postmodern Narrative Techniques in Slaughterhouse-Five
Authors: Shi Jing
Published: April 2019

Kurt Vonnegut is admitted as a great master of postmodern writer. Vonnegut’s success is mainly attributed to his unique narrative approaches, various expressive methods and dramatic artistic effects. The application of metafiction is particularly obvious and significant in his novels. Slaughterhouse-Five is one of typical examples of the successful adoption of metafiction. The metafiction of Vonnegut’s style, applied in Slaughterhouse-Five, shows itself in three distinctive approaches—non-linear narrative, collage and parody. Based on postmodern narrative theory, the application of these three distinctive narrative techniques will be analyzed in details in this thesis. The analysis mainly includes the reasons why they are applied in the novel and the functions how they work. The paper is mainly divided into five parts. Relevant information of Vonnegut, postmodern metafiction and previous researches are introduced in the first chapter. After getting better acquainted with basic knowledge, three narrative methods of Vonnegut’s metafiction including non-linear narrative, collage and parody are separately and detailedly analyzed in the following three chapters. Every method applied in the novel deepens the anti-war theme, and then exposes war’s evilness and absurdity further. Finally, the last part is a conclusion which is an emphasis on effects of Vonnegut’s unique narrative techniques.
On the Way to a Good Man Again—An Analysis of Amir in The Kite Runner from Perspective of Freud’s Personality Structure Theory
Authors: Wen Ting
Published: April 2019

The Kite Runner is the first novel that was written by Afghan-American writer Khaled Hosseini. This novel tells the story of an Afghan immigrant boy called Amir in the United States and his spiritual redemption of his fault made during his childhood, using the first-person perspective. This thesis attempts to analyze Amir's triple personality thoroughly: id, ego and superego from Freud’s personality structure theory, making readers have a deep understanding of how Amir lost, how to form the powerful self, and finally to complete the sublimation of his personality to be a good man. Meanwhile it aims to analyze how Amir forms his own ego.
Akademik Personel Performans Değerlendirmesinde Bir Karar Destek Sistemi Önerisi
Authors: AYDEMİR Emrah
Published: April 2019

Üniversiteler eğitim düzeyinin son kademesi olup, bilim ve teknoloji alanlarındaki faaliyetleri ile özgün ve lider bir üniversite olmayı amaçlarlar. Elbette ki bu amaca ulaşmanın en büyük gerekliliği, bilimsel yetkinliğe sahip akademik personel sayısıdır. Bir akademik personelin yetkinliği ise farklı ölçüt sistemleri ile değerlendirilmektedir. Üniversitelere atanma ve yükseltme, doçentlik ve akademik teşvik gibi ölçüt sistemleri akademik personelin akademik geçmişine bakarak; yayınlarını, makalelerini, bildirilerini, kitap ve kitap bölümlerini, verdiği derslerini, lisans ve lisansüstü tez danışmanlıklarını, ödüllerini, üyeliklerini, idari görevlerini, projelerini, araştırmalarını, atıflarını, sergilerini vb. birçok çalışmasını içermektedir. Fakat buradaki ölçütler ve ölçütlerin değerlendirilme puanları üniversiteden üniversiteye farklılık göstermektedir. Ölçütler genel olarak akademik başarı ve yayın kriterlerinden oluşmakta iken personelin daha önce post-doktora yapıp yapmadığını veya daha öncesinde kaç yıllık bir akademik geçmişe sahip olduğunu dikkate almamaktadır. Bu çalışmada ise üniversitelerin mevcut atama ve yükseltme yönergeleri incelenerek tüm ölçütler çıkartılmış ve bu ölçütlerin değerlendirilmesi için oluşturulan karar destek sistemi önerisi (KDS) sunulmuştur. KDS aracılığıyla her üniversite kendi ölçüt sistemine göre parametre değerlerini girip puanlamaları görerek; üniversite, fakülte veya bölüm bazında sıralamalar yapabilecektir. Aynı zamanda her öğretim elemanı kendisinin her bir alandaki puanını diğer bölüm veya kişilere göre durumunu analiz edebilecektir. Tüm bunların yanı sıra Türkiye’deki tüm yükseköğretim kurumları da diğer kurumlar içerisinde kendi pozisyonunu değerlendirme imkânı olacaktır. Ayrıca akademik personelin performans ölçümüne etki edecek tüm verilerin toplanması ile hem değerlendirmenin eksik yanları kapatılacak olup hem de tüm akademik personelin özgeçmişlerinin yayınlanması sağlanacaktır.
Uçak Motoru Sağlığı için Uzun-Kısa Süreli Bellek Yöntemi ile Öngörücü Bakım
Authors: KIZRAK Merve Ayyüce , BOLAT Bülent
Published: April 2019

Otomotiv, uçak ve fabrika otomasyonu gibi özellikle maliyetli motor bakımı gerektiren uygulamalarda öngörücü bakım önemli bir yer almaktadır. Hem iş güvenliği hem de araçlardan sağlanacak verim bakımından motorların bakım periyotlarını önceden kestirmek ve buna göre iş yönetim stratejisi geliştirmek önemlidir. Öngörücü bakım için motorlardan alınan sensör verileri motorun yıpranma süresini ve seviyesini belirlemekte kullanılmaktadır. Çalışmada Uzun-Kısa Süreli Bellek (LSTM) yapısı kullanılarak, uçak motorlarının kalan yaşam ömürlerinin tahmin edilmesi amaçlanmıştır. NASA tarafından sunulmuş olan bir veri kümesi üzerinde LSTM yapısı test edilmiştir ve elde edilen sonuçlar farklı yöntemlerle kıyaslanmıştır. Yapılan uygulamaların sonucunda en yüksek sınıflandırma başarımı %98,876; en düşük ortalama mutlak hata ise 1,343 olarak LSTM ile elde edilmiştir.
Da inesgotável matéria do mundo: uma aproximação pós-humanista à escrita de Maria Gabriela Llansol
Authors: Soeiro Ricardo
Published: April 2019

Resumo: O presente artigo centra-se sobre Lisboaleipzig 1: o encontro inesperado do diverso, de Maria Gabriela Llansol, com o objetivo de refletir sobre o enquadramento pós-humanista evidenciado pela escrita de Llansol, procurando argumentar que nesta obra se ensaia uma celebração da interdependência entre o humano e o não humano. Contemplar-se-á, igualmente, uma análise mais ampla da obra de Llansol que, na nossa óptica, incorpora uma ética pós-humanista e encena formas dinâmicas e plurais de subjetividade.Palavras-chave: Literatura portuguesa contemporânea; Maria Gabriela Llansol; pós-humanismo; representações da subjectividade.Abstract: Our inquiry will focus on Maria Gabriela Llansol’s Lisboaleipzig 1: o encontro inesperado do diverso (Lisboaleipzig 1: The Unexpected Encounter with Diversity), aiming at reflecting on the posthumanist framework of Llansol’s writing in which it will be claimed that an interdependence between the human and the nonhuman is being enacted. We will also engage in a broader analysis of Llansol’s oeuvre, a body of work which, from our perspective, embodies posthumanist ethics and enacts dynamic and plural forms of subjectivity.Keywords: Contemporary portuguese literature; Maria Gabriela Llansol; posthumanism; representations of subjectivity.
Muş İlinde Özel Süt Sığırcılığı İşletmelerinde Süt Verim Özelliklerinin Belirlenmesi
Authors: BAKIR Galip , KİBAR Mustafa
Published: April 2019

Bu araştırma,
süt sığırcılığı işletmelerinin süt verim özelliklerine ait uygulamalarını
belirlemek amacıyla, Muş İli ve 5 ilçesinde 346 işletme sahibiyle yüz yüze
anket çalışması yapılmıştır. İşletmelerde genelde sağım elle ve günde iki kez
yapılırken, sağım süresi ortalama 7.4 ay olarak bulunmuştur. Günlük ortalama
süt verimi 10.3 kg iken, il genelinde süt verimi işletmelerin %50.7’sinde 6-10
kg aralığında yoğunlaşmaktadır. İşletmecilerin %59.3’ü ineklerden elde edilen
sütün yeterli olmadığını ve %86.4’ü süt veriminin mevsime göre değiştiğini
belirtmiştir. İşletmelerin %82.6’sı inekleri kuruya çıkarmakta ve %55.8’i 60
gün kuruda tutmaktadır. İşletmelerin %54’ü sağım öncesi meme temizliği yaptığı
ve %32.2’sinin sağım sonrası daldırma işlemi yaptığı belirlenmiştir. Üretilen
süt işletmelerin %70.5’inde peynir-yoğurt-tereyağı şeklinde ürüne dönüştürülmektedir.
Hayvan sayısı az olan işletmelerde üretilen sütün tamamı ev ihtiyacı için
tüketilirken, diğer işletmelerde ise genellikle sütün %10-15’i tüketilmektedir İşletmelerde
süt verimini artırmak için, barınak dahil alt yapısının iyileştirilmesi, yetiştirilen
ırklar içinde kültür ırklarının oranının artırılması, mera imkanı ve mera ot
kalitesinin artırılması yanında hayvancılığın sadece meraya dayalı yapılmaması
ile yetiştiricilerin teknik bilgi düzeylerinin artırılması gibi bir takım
tedbirlerin alınması önerilmektedir.
Adolescent gynae clinic - need of the day: a prospective study at a tertiary care centre
Authors: Jain Anita , Singh Dibya
Published: April 2019

Background: To study common gynaecological problems in adolescent girls and to establish the need of adolescent clinic.Methods: A prospective study was conducted including 250 adolescent girls attending gynaecology OPD. Girls were evaluated by detailed history, thorough clinical examination and investigations such as haemogram, coagulation profile, hormonal assays, ultrasound examination of abdomen and pelvis, as and when indicated.Results: Majority of girls had complaints related to menstrual disorders i.e. 58.3%. Most common causes of menstrual abnormalities were dysfunctional uterine bleeding (42.85%) followed by polycystic ovarian syndrome (26.19%) and pelvic inflammatory disease (15.47%).Conclusions: Problems are specific to this age group, setting up of separate adolescent clinics is desirable of efficient management where they can be provided adequate privacy to discuss their problems openly.
Umbilical endometriosis along with peritoneal endometriosis: a case report
Authors: Devi T. Ramani , Devi C. Archana , Devi C. Aparna
Published: April 2019

Incidence of endometriosis is around 10 to 15% in women of reproductive age group. Umbilical endometriosis is a very rare entity. Extra genital endometriosis accounts to 3% of endometriosis. Incidence of umbilical endometriosis is 0.5%-4% of extra genital endometriosis. 30 years old multi gravida was referred to our hospital with c/o periodic bleeding from the umbilicus for the past 3 months. She was also having dysmenorrhoea for about 3 months. On examination, patient had a small bluish nodule in the umbilicus around 1.5x1.2 cm in size. Clinically there was suspicion of pelvic endometriosis as the uterus was retroverted and fixed. CT abdomen showed a small hypo-echoeic area in the umbilicus and uterus was adenomyotic with normal ovaries. Patient was given the option of laparoscopy and excision of umbilicus, as there was suspicion of peritoneal endometriosis and the patient also insisted upon laparoscopic sterilization. Laparoscopy showed early peritoneal endometriosis with pelvic adhesions and the same adhesiolysis was done along with cauterization of endometriosis. Sterilization was also done as per the patient’s request. Umbilical excision and layer closure was done. Umbilical endometriosis is a rare entity. This patient had associated early pelvic endometriosis. Umbilical endometriosis could be secondary to the lympho vascular spread from the pelvic endometriosis or primary umbilical endometriosis. History, clinical and imaging were pointing towards umbilical endometriosis. Surgical excision of umbilical endometriosis and cauterisation of early pelvic endometriosis were done. Patient needs follow up. Umbilical endometriosis may be primary or secondary which needs total excision and follow up.
Cesarean scar pregnancy: scope for hysteroscopy
Authors: Shah Nitin H. , Joshi Aditi V. , Agrawal Renu
Published: April 2019

Scar ectopic pregnancy also known as cesarean scar pregnancy is a rare form of an extrauterine pregnancy. The blastocyst is implanted at the site of the previous cesarean scar. Most patients remain asymptomatic and are detected on routine ultrasonography imaging. The diagnosis and management of this condition is hence challenging and difficult. A timely ultrasonography in the early weeks of gestation is the key to preventing catastrophic events like uterine perforation and excessive hemorrhage. There is a wide armamentarium of treatment modalities to choose from, however each case must be individualised. Medical management has its own limitations and often patients are required to have a long-term follow-up. We present a case of a cesarean scar pregnancy managed conservatively with systemic methotrexate but subsequently requiring surgical intervention done successfully via hysteroscopy. A repeat ultrasonography done a fortnight later revealed no retained products of conception.
Transanal endorectal pull-through in children as the treatment for Hirschsprung’sd in Aceh, Indonesia
Authors: Isa Muntadhar M. , Syahputra Dian A. , Hutagalung Muhammad Bayu Z.
Published: April 2019

Background: One-stage pull-through operation has become increasingly popular for the treatment of Hirschsprung's disease. The advantages of total transanal pull-through include minimal resection of the dilated ganglionic part of the colon, shorter hospital stay, decreased total cost, lower risk of adhesive intestinal obstruction.Methods: A retrospective study of patients with HD underwent transanal endorectal pull-through (TERPT) procedure treated at Dr. Zainoel Abidin Hospital Banda Aceh, Indonesia between January 2010 – December 2013. We assessed patients characteristic, outcome and complication including Hirsch sprung associated enterocolitis (HAEC).Results: A total 77 patients were included in this study. The mean age was 13.01 months (range from 11 days – 8 years old). Most of the patients (55.8%) were male and female (44.2%). Clinical classification of HD: short segment 74 patients (96.1%) and ultra-short segment 3 patients (3.9%). The mean of bowel resection length in TERPT procedure was 18.64 cm (range from 7–25 cm). There is no mortality associated with TERPT procedure. Hirsch sprung associated enterocolitis (HAEC) occurred in 43 subjects (54.5%). Statistical analysis showed the significant relation between age at surgery and HAEC (p= 0.000) and no significant relationship between gender (p=0.425) and bowel resection length (p=0.780) with HAEC.Conclusions: Transanal endorectal pull-through procedure has been shown as an effective minimally invasive treatment in resolving obstructive symptoms in ultra–short segment of HD patients. The number of HAEC incidence among HD patients underwent TERPT significantly increased with older age of children.
The role of diagnostic laparoscopy in the era of modern imaging techniques: a study from a single center
Authors: Parray Muzafar Yousuf , Malik Ajaz Ahmad , Hassan Yaqoob , Wani Ishfaq Ahmad , Ahmad Wani Munir Ahmad , Bashir Wani Shahid
Published: April 2019

Background: Despite the tremendous progressive evolution in the field of medicine, wherein, most of the diseases can be diagnosed based on history, clinical examination and investigations, there are quite a number of diseases which remain undiagnosed. It is here, where the role of diagnostic laparoscopy becomes important to reach to a conclusion for further management of patients.Methods: This study comprising of 70 patients undergoing diagnostic laparoscopy at SKIMS over a period of 4 years. This study was done to evaluate the role of diagnostic laparoscopy in patients with acute and chronic abdominal conditions wherein final diagnosis could not be achieved after all necessary imaging, serological, cytological, and microbiological investigations.Results: Out of 70 patients subjected to diagnostic laparoscopy in our study, the commonest indication was as cites of undetermined etiology (42.9%) followed by chronic abdominal pain (25.7%) diffuse liver disease (11.4%) acute abdominal pain (SAIO, cholecystitis, acute appendicitis, PID, endometriosis) (5.7%) abdominal tuberculosis (4.3%) focal liver disease (2.9%) bleeding per rectum (2.9%) abdominal malignancy (2.9%) and primary infertility (1.4)%. The post diagnostic laparoscopy outcome (final diagnosis) were abdominal malignancy 22 (31.4%) followed by abdominal tuberculosis 16 (22.9%) diffuse liver disease 6 (8.6%) focal liver disease 6 (8.6%) PID 4 (5.7%) SAIO 4 (5.7%) post-operative pelvic adhesions 3 (4.3%) Meckel’s diverticulum 2 (2.9%) abdominal plus pulmonary tuberculosis 1 (1.4%), endometriosis 1 (1.4%), ovarian cyst 1 (1.4%), pseudomyxoma peritonei 1 (1.4%), chronic appendicitis 1 (1.4%) and inconclusive 2 (2.9%). Diagnostic laparoscopy confirmed pre-operative diagnosis in 10 (14.3%) patients. In 29 (41.4%) patients pre-operative diagnosis was corrected by diagnostic laparoscopy. In 29 (41.4%) patients diagnosis was made only after diagnostic laparoscopy.Conclusions: Diagnostic laparoscopy is a safe, quick, and effective adjunct to non surgical diagnostic modalities, for establishing a conclusive diagnosis with high percentage of accuracy in diagnosis and impact in further management in selected patients.