bluuebunny/crossref_metadata_2025 huggingface dataset:
Longitudinal Dynamics of 3-Dimensional Components of Selfhood After Severe Traumatic Brain Injury: A qEEG Case Study
Authors: Fingelkurts Andrew A. , Fingelkurts Alexander A.
Published: February 2017

In this report, we describe the case of a patient who sustained extremely severe traumatic brain damage with diffuse axonal injury in a traffic accident and whose recovery was monitored during 6 years. Specifically, we were interested in the recovery dynamics of 3-dimensional components of selfhood (a 3-dimensional construct model for the complex experiential selfhood has been recently proposed based on the empirical findings on the functional-topographical specialization of 3 operational modules of brain functional network responsible for the self-consciousness processing) derived from the electroencephalographic (EEG) signal. The analysis revealed progressive (though not monotonous) restoration of EEG functional connectivity of 3 modules of brain functional network responsible for the self-consciousness processing, which was also paralleled by the clinically significant functional recovery. We propose that restoration of normal integrity of the operational modules of the self-referential brain network may underlie the positive dynamics of 3 aspects of selfhood and provide a neurobiological mechanism for their recovery. The results are discussed in the context of recent experimental studies that support this inference. Studies of ongoing recovery after severe brain injury utilizing knowledge about each separate aspect of complex selfhood will likely help to develop more efficient and targeted rehabilitation programs for patients with brain trauma.
Mechanical removal of a refluxed Onyx piece from the middle cerebral artery using the Solitaire Stent: Technical report
Authors: Gungor Dilara , Oğuz Şükrü , Dinc Hasan
Published: February 2017

Onyx reflux into the parent artery is a rare and sometimes significant complication in the treatment of cerebral arteriovenous malformations (AVMs). We report a patient who presented with Onyx reflux into the M1 segment of the middle cerebral artery (MCA) during embolization of a right temporal AVM. The refluxed Onyx cast was successfully removed by a mechanical thrombectomy device using a self-expandable and fully retrievable Solitaire AB stent.
Data monitoring committees: Promoting best practices to address emerging challenges
Authors: Fleming Thomas R , DeMets David L , Roe Matthew T , Wittes Janet , Calis Karim A , Vora Amit N , Meisel Alan , Bain Raymond P , Konstam Marvin A , Pencina Michael J , Gordon David J , Mahaffey Kenneth W , Hennekens Charles H , Neaton James D , Pearson Gail D , Andersson Tomas LG , Pfeffer Marc A , Ellenberg Susan S
Published: February 2017

Background and Purpose:

Data monitoring committees are responsible for safeguarding the interests of study participants and assuring the integrity and credibility of clinical trials. The independence of data monitoring committees from sponsors and investigators is essential in achieving this mission. Creative approaches are needed to address ongoing and emerging challenges that potentially threaten data monitoring committees’ independence and effectiveness.

Methods:

An expert panel of representatives from academia, industry and government sponsors, and regulatory agencies discussed these challenges and proposed best practices and operating principles for effective functioning of contemporary data monitoring committees.

Results and Conclusions:

Prospective data monitoring committee members need better training. Options could include didactic instruction as well as apprenticeships to provide real-world experience. Data monitoring committee members should be protected against legal liability arising from their service. While avoiding breaches in confidentiality of interim data remains a high priority, data monitoring committees should have access to unblinded efficacy and safety data throughout the trial to enable informed judgments about risks and benefits. Because overly rigid procedures can compromise their independence, data monitoring committees should have the flexibility necessary to best fulfill their responsibilities. Data monitoring committee charters should articulate principles that guide the data monitoring committee process rather than list a rigid set of requirements. Data monitoring committees should develop their recommendations by consensus rather than through voting processes. The format for the meetings of the data monitoring committee should maintain the committee’s independence and clearly establish the leadership of the data monitoring committee chair. The independent statistical group at the Statistical Data Analysis Center should have sufficient depth of knowledge about the study at hand and experience with trials in general to ensure that the data monitoring committee has access to timely, reliable, and readily interpretable insights about emerging evidence in the clinical trial. Contracts engaging data monitoring committee members for industry-sponsored trials should have language customized to the unique responsibilities of data monitoring committee members rather than use language appropriate to consultants for product development. Regulatory scientists would benefit from experiencing data monitoring committee service that does not conflict with their regulatory responsibilities.
Accuracy and User Performance Evaluation of a New, Wireless-enabled Blood Glucose Monitoring System That Links to a Smart Mobile Device
Authors: Bailey Timothy S. , Wallace Jane F. , Pardo Scott , Warchal-Windham Mary Ellen , Harrison Bern , Morin Robert , Christiansen Mark
Published: February 2017

Background:

The new Contour®Plus ONE blood glucose monitoring system (BGMS) features an easy-to-use, wireless-enabled blood glucose meter that links to a smart mobile device via Bluetooth® connectivity and can sync with the Contour™ Diabetes app on a smartphone or tablet.

Methods:

The accuracy of the new BGMS was assessed in 2 studies according to ISO 15197:2013 criteria. In Study 1 (laboratory study), fingertip capillary blood samples from 100 subjects were tested in duplicate using 3 test strip lots. In Study 2 (clinical study), 134 subjects with type 1 or type 2 diabetes enrolled at 2 clinical sites. BGMS results and YSI analyzer (YSI) reference results were compared for fingertip blood obtained by untrained subjects’ self-testing and for study staff–obtained fingertip, subject palm, and venous results.

Results:

In Study 1, 99.0% (594/600) of combined results for all 3 test strip lots fulfilled ISO 15197:2013 Section 6.3 accuracy criteria. In Study 2, 99.2% (133/134) of subject-obtained capillary fingertip results, 99.2% (133/134) of study staff–obtained fingertip results, 99.2% (125/126) of subject-obtained palm results, and 100% (132/132) of study staff–obtained venous results met ISO 15197:2013 Section 8 accuracy criteria. Moreover, 95.5% (128/134) of subject-obtained fingertip self-test results were within ±10 mg/dl (±0.6 mmol/L) or ±10% of the YSI reference result. Questionnaire results showed that most subjects found the BGMS easy to use.

Conclusions:

The BGMS exceeded ISO 15197:2013 accuracy criteria both in the laboratory and in a clinical setting when used by untrained subjects with diabetes.
Teaching Large Sections of a Business Communication Course
Authors: Wright Carol
Published: February 2017

The purpose of this research is to examine specific examples of how business communication courses are delivered in large, face-to-face university classes to discover implications of these large courses. This case study reviewed four classes from two different midsized universities whose classes range from 48 to 300 students. Findings suggest that, when faced with the possibility of teaching more students, it is important to understand that pedagogical strategies may need to be adjusted to maintain student learning. These strategies include modifying the course to the lecture/lab structure, limiting the amount of writing, or allowing the instructor to teach fewer courses.
Increasing Student Interaction in Technical Writing Courses in Online Environments
Authors: Virtue Drew
Published: February 2017

This article examines how the levels of student interaction change through the use of small groups and moderators in online writing courses. The study examines three technical and professional online writing courses: one course that employs small groups and group moderators and two courses that have no small groups or moderators. The results of this study show that the amount of interaction between students in online writing courses increases dramatically by incorporating small groups and peer moderators.
Cardiac and renal complications of carfilzomib in patients with multiple myeloma
Authors: Dimopoulos Meletios A. , Roussou Maria , Gavriatopoulou Maria , Psimenou Erasmia , Ziogas Dimitrios , Eleutherakis-Papaiakovou Evangelos , Fotiou Despina , Migkou Magdalini , Kanellias Nikolaos , Panagiotidis Ioannis , Ntalianis Argyrios , Papadopoulou Elektra , Stamatelopoulos Kimon , Manios Efstathios , Pamboukas Constantinos , Kontogiannis Sofoklis , Terpos Evangelos , Kastritis Efstathios
Published: February 2017

Key Points

Carfilzomib is associated with reversible cardiotoxicity in 12% of consecutive myeloma patients. Transient renal toxicity is common, but carfilzomib may improve renal function in myeloma-related renal impairment.
Intermediate-Acting Nondepolarizing Neuromuscular Blocking Agents and Risk of Postoperative 30-Day Morbidity and Mortality, and Long-term Survival
Authors: Bronsert Michael R. , Henderson William G. , Monk Terri G. , Richman Joshua S. , Nguyen Jennifer D. , Sum-Ping John T. , Mangione Michael P. , Higley Binh , Hammermeister Karl E.
Published: February 2017

BACKGROUND:

Nondepolarizing neuromuscular blocking drugs (NNMBDs) are commonly used as an adjunct to general anesthesia. Residual blockade is common, but its potential adverse effects are incompletely known. This study was designed to assess the association between NNMBD use with or without neostigmine reversal and postoperative morbidity and mortality.

METHODS:

This is a retrospective observational study of 11,355 adult patients undergoing general anesthesia for noncardiac surgery at 5 Veterans Health Administration (VA) hospitals. Of those, 8984 received NNMBDs, and 7047 received reversal with neostigmine. The primary outcome was a composite of respiratory complications (failure to wean from the ventilator, reintubation, or pneumonia), which was “yes” if a patient had any of the 3 component events and “no” if they had none. Secondary outcomes were nonrespiratory complications, 30-day and long-term all-cause mortality. We adjusted for differences in patient risk using propensity matched (PM) followed by assessment of the association of interest by logistic regression between the matched pairs as our primary analysis and multivariable logistic regression (MLR) as a sensitivity analysis.

RESULTS:

Our primary aim was to assess the adverse outcomes in the patients who had received NNMBDs with and without neostigmine. Administration of an NNMBD without neostigmine reversal compared with NNMBD with neostigmine reversal was associated with increased odds of respiratory complications (PM odds ratio [OR], 1.75 [95% confidence interval [CI], 1.23–2.50]; MLR OR, 1.71 [CI, 1.24–2.37]) and a marginal increase in 30-day mortality (PM OR, 1.83 [CI, 0.99–3.37]; MLR OR, 1.78 [CI, 1.02–3.13]). However, there were no statistically significant associations with nonrespiratory complications or long-term mortality. Patients who were administered an NNMBD followed by neostigmine had no differences in outcomes compared with patients who had general anesthesia without an NNMBD.

CONCLUSIONS:

The use of NNMBDs without neostigmine reversal was associated with increased odds of our composite respiratory outcome compared with patients reversed with neostigmine. Based on these data, we conclude that reversal of NNMBDs should become a standard practice if extubation is planned.
Cross-Disciplinary Perceptions of Structured Interprofessional Rounds in Promoting Teamwork Within an Academic Tertiary Care Obstetric Unit
Authors: Chau Anthony , Vijjeswarapu Mary A. , Hickey Margaret , Acker David , Huang Chuan-Chin , Tsen Lawrence C.
Published: February 2017

BACKGROUND:

In 2005, physician and nursing leaders at Brigham and Women’s Hospital initiated structured interprofessional rounds (SIPRs) on the labor and delivery (L&D) suite to improve team communication. We performed a cross-sectional analysis of providers’ perceptions of SIPRs and their effectiveness in improving teamwork. We hypothesized that on average, providers would perceive SIPRs as being effective in promoting teamwork, but ratings would differ among professional groups.

METHODS:

After a factor analysis and internal consistency assessment, a 19-item paper-based questionnaire was used to evaluate providers’ perceptions using a 5-point Likert scale. Respondents included L&D nurses, midwives, obstetricians, and anesthesiologists who participate in SIPRs. The primary aim was to evaluate the providers’ perceptions of SIPRs and their association with professional roles. The outcome was total response score for each provider, ranging from 19 to 95; perception of SIPRs as being effective in promoting teamwork was defined as having a total response score of >66.5 (mean score, >3.5 per question). A univariable linear regression model was performed, followed by a multivariable analysis adjusting for predictors that modified the outcome; predictors included years of professional practice, years of experience on the L&D suite, number of clinical work hours worked weekly, and principal shift assignment among nurses. The associations between these predictors and providers’ perceptions were assessed as a secondary aim.

RESULTS:

A total of 234 practitioners responded (100% response rate). The mean total response score (SD) for all providers was 73.3 (9.5). After multivariable adjustment, the mean total response scores were significantly higher for obstetric providers than for anesthesia (Δ mean, 6.5, 95% CI, 0.3, 12.7 P = .036) and midwifery (Δ mean, 12.5, 95% CI, 2.0, 23.0, P = .009) providers. Providers scored significantly lower if they worked >60 clinical hours per week compared with ≤20 (Δ mean, −13.7, 95% CI, −25.3, −2.1, P = .009), 21–40 (Δ mean, −8.0, 95% CI, −15.8, −0.09, P = .049), or 41–60 hours (Δ mean, −8.1, 95% CI, −14.5, −1.7, P = .004). Duration of practice in professional role and experience on the L&D suite were not predictive of SIPRs ratings.

CONCLUSIONS:

On average, providers on the L&D suite perceive SIPRs as being effective in promoting teamwork. Perception ratings were significantly influenced by professional role and number of clinical hours worked weekly, suggesting that these factors should be explored in future research to minimize perception gaps and support a dynamic culture of interprofessional collaboration.
Tertiary lymphoid organs in systemic autoimmune diseases: pathogenic or protective?
Authors: Shipman William D. , Dasoveanu Dragos C. , Lu Theresa T.
Published: February 2017

Tertiary lymphoid organs are found at sites of chronic inflammation in autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. These organized accumulations of T and B cells resemble secondary lymphoid organs and generate autoreactive effector cells. However, whether they contribute to disease pathogenesis or have protective functions is unclear. Here, we discuss how tertiary lymphoid organs can generate potentially pathogenic cells but may also limit the extent of the response and damage in autoimmune disease.
Letters
Authors:   Born Free Foundation, Leitch Neil , Hadland Cheryl
Published: February 2017

MA Education Ltd, St Jude's Church, Dulwich Road, London, SE24 0PB neil.henty@markallengroup.com
Contraceptive Failure in the United States: Estimates from the 2006–2010 National Survey of Family Growth
Authors: Sundaram Aparna , Vaughan Barbara , Kost Kathryn , Bankole Akinrinola , Finer Lawrence , Singh Susheela , Trussell James
Published: February 2017

CONTEXT

Contraceptive failure rates measure a woman's probability of becoming pregnant while using a contraceptive. Information about these rates enables couples to make informed contraceptive choices. Failure rates were last estimated for 2002, and social and economic changes that have occurred since then necessitate a reestimation.

METHODS

To estimate failure rates for the most commonly used reversible methods in the United States, data from the 2006–2010 National Survey of Family Growth were used; some 15,728 contraceptive use intervals, contributed by 6,683 women, were analyzed. Data from the Guttmacher Institute's 2008 Abortion Patient Survey were used to adjust for abortion underreporting. Kaplan‐Meier methods were used to estimate the associated single‐decrement probability of failure by duration of use. Failure rates were compared with those from 1995 and 2002.

RESULTS

Long‐acting reversible contraceptives (the IUD and the implant) had the lowest failure rates of all methods (1%), while condoms and withdrawal carried the highest probabilities of failure (13% and 20%, respectively). However, the failure rate for the condom had declined significantly since 1995 (from 18%), as had the failure rate for all hormonal methods combined (from 8% to 6%). The failure rate for all reversible methods combined declined from 12% in 2002 to 10% in 2006–2010.

CONCLUSIONS

These broad‐based declines in failure rates reverse a long‐term pattern of minimal change. Future research should explore what lies behind these trends, as well as possibilities for further improvements.
Desacuerdo lógico y agregación
Authors: Tajer Diego
Published: February 2017

En este artículo, exploro la posibilidad de aplicar los métodos y resultados de la Agregación de Juicios al problema del desacuerdo lógico. Es decir, desarrollo y evalúo maneras en que individuos que desacuerdan lógicamente pueden generar una lógica colectiva. Pruebo una versión de la paradoja discursiva, donde el voto por mayoría en un grupo de lógicos estructurales puede generar lógicas subestructurales, y luego elaboro un resultado de imposibilidad más general. Más adelante, analizo diferentes maneras de evitar la paradoja, en particular aquellas que apelan a restricciones de dominio. Finalmente, analizo brevemente la aplicación de estos resultados al debate sobre paradojas semánticas.
Effect of different protein and energy levels in concentrate diets on nutrient intake and milk yield of Saanen x Etawah Grade goats
Authors: Supriyati . , Krisnan R. , Budiarsana I.G.M. , Praharani L.
Published: February 2017

Dairy goat contributes to food and nutrition security. However, information on nutrient consumption and milk yield, as well as milk composition of Saanen x Etawah (SAPERA) grade goat is limited. This experiment was done to evaluated nutrient intake, milk yield and its composition of lactating SAPERA goats fed with different levels of dietary energy and protein in concentrate diet. Thirty multiparous SAPERA goats were used in a randomized block design with three treatments (R1, R2 and R3) and ten replications for 12 weeks of lactation. The concentrate diets were formulated to contain: 18% CP and 72% TDN (R1), 17% CP and 75% TDN (R2), 16% CP and 78% TDN (R3). Those does were penned individually, and fed by basal diet (fresh chopped King Grass ad libitum, 500 g of fresh mixed forages) and 1 kg of experimental concentrate. Results showed that the treatments had significant (P<0.05) effects on CP, DIP, Ca, P intakes and FCR but had no significant (P>0.05) effects on DM and TDN intake. No significant differences were found in milk yield and milk composition between treatments. In conclusion, this trial suggested that the best feed for lactating SAPERA goats was the mixture of chopped grasses, mixed forages and concentrate diets (16% CP and 78% TDN) with 160 g/kg CP and 750 g/kg TDN of the total DM, produced a milk of 1.55 kg/d with 90 g/day of milk fat, 43 g/day of milk protein and 75 g/day of milk lactose.
Multivariate extensions of expectiles risk measures
Authors: Maume-Deschamps Véronique , Rullière Didier , Said Khalil
Published: February 2017

This paper is devoted to the introduction and study of a new family of multivariate elicitable risk measures. We call the obtained vector-valued measures multivariate expectiles. We present the different approaches used to construct our measures. We discuss the coherence properties of these multivariate expectiles. Furthermore, we propose a stochastic approximation tool of these risk measures.
Cleaning Up the Clinic: Examining Mentor Teachers’ Perceptions of Urban Classrooms and Culturally Responsive Teaching
Authors: Thomas-Alexander Sashelle , Harper Brian E.
Published: February 2017

This study investigates the beliefs of mentor teachers with respect to urban classrooms as well as their confidence level with respect to working with a diverse array of urban students. When presented with a simple, unambiguous query concerning urban schools and the Culturally Responsive Teaching Self-Efficacy Scale, mentor teachers in this sample expressed overwhelmingly negative views of the students, schools and communities in which they teach. Recommendations are made with respect to the preparation, support and supervision of mentor teachers who work in urban schools.
Diverse Chlamydia-like agents associated with epitheliocystis infection in two cyprinid fish species, the common carp (Cyprinus carpio L.) and the gibel carp (Carassius auratus gibelio L.)
Authors: Sellyei Boglárka , Molnár Kálmán , Székely Csaba
Published: February 2017

During a general annual fish health survey in natural waters and ponds, epitheliocystis infections were recorded in fingerlings of two cyprinid fish species, the cultured common carp and the wild gibel carp. Benign and heavy infections were equally observed without mortality. In addition to the general health inspection of fish, histopathological examinations of infected gills and molecular biological investigations of separated epitheliocysts were performed. Epitheliocysts were formed both in the interlamellar epithelial cells and in the lamella-free multilayered epithelium of the gill filaments. At the early stage of infection darkstaining inclusion bodies densely stuffed with some pathogenic agents were located at the centre of the cell, while in a progressive stage of the process inclusion bodies within the host cells were disseminated in the cytoplasm and stained pale. Molecular studies demonstrated three different agents related to Neochlamydia, Protochlamydia and Piscichlamydia based on sequence analysis of short regions of the 16S rRNA gene. Among them, Piscichlamydia is a primary fish pathogen, while Neochlamydia and Protochlamydia mostly infect free-living amoebae but have adapted thoroughly to fish.
Effect of fulvic and humic acids on iron and manganese homeostasis in rats
Authors: Szabó József , Vucskits András Valentin , Berta Erzsébet , Andrásofszky Emese , Bersényi András , Hullár István
Published: February 2017

The objective of this study was to investigate the effects of fulvic acid (FA) and humic acid (HA) as the two main compounds of humic substances, separately on Fe and Mn homeostasis. Seventy-two male Wistar rats were randomly divided into 9 experimental groups. The control diet (AIN-93G formula) and diets supplemented with 0.1%, 0.2%, 0.4% and 0.8% HA or FA were fed for 26 days. Fe and Mn concentrations of the large intestinal content, liver, kidney, femur and hair were determined. No significant differences were observed in the production parameters. The effects of FA and HA on iron homeostasis were significantly different. FA proved to be a good iron source, and slightly increased the iron content of liver and kidney, but — up to a dietary iron level of 52.7 mg/kg — it did not influence the efficiency of iron absorption. Above a dietary iron level of 52.7 mg/kg down-regulation of Fe absorption can be assumed. HA significantly stimulated the iron uptake and there was no down-regulation of Fe absorption up to 0.8% dietary HA supplementation level (61.5 mg Fe/kg diet). In the HA groups the iron content of the liver and kidney decreased significantly, suggesting that in spite of the better Fe absorption, the HA—Fe complex does not provide iron to the investigated organs. Neither FA nor HA supplementation influenced the Fe content of the femur and hair and slightly decreased the Mn concentration in the large intestinal content. This effect was significant (with a 22.7% Mn concentration decrease) only at the HA supplementation rate of 0.8%. Neither FA nor HA influenced significantly the Mn concentrations of the liver, kidney and femur. The Mn concentration of the hair in rats receiving FA- or HA-supplemented diets was higher than in the control rats; however, this result needs further confirmation.
Determining the risk of intra-community transmission of tuberculosis in the northwest of Iran through 15 loci MIRU-VNTR typing
Authors: Afaghi-Gharamaleki Ali , Moaddab Seyyedreza , Darbouy Mojtaba , Ansarin Khalil , Hanifian Shahram
Published: February 2017

This study was carried out in order to investigating the effect of travelling on the transmission of tuberculosis from high- to low-burden TB countries. Mycobacteria samples isolated from patients of distinct and relatively co-related countries (Azerbaijan Republic and Tabriz [located in the northwest of Iran]) were analyzed through 15 loci MIRU-VNTR typing method. PCR was done using special primers for each of the loci; then the number of allele repeats for all loci were determined by the size of their fragments. Finally, the created numeric patterns for each isolate were analyzed and clustered, using MIRU-VNTRplus.org website. All 119 isolates dispersing at 106 distinct patterns were composed of 10 clusters with 23 members and 96 unique patterns. Nine and five loci had high and moderate discriminatory power, respectively, but only one of them was poor in clustering. The study showed that 89.08% of TB cases involved resulted from the reactivation pattern and 10.92% were related to ongoing transmission. Although Azerbaijan Republic is a higher-burden TB region than Tabriz and Azerbaijan people make frequent tours to Tabriz to receive low or free medical services, the findings showed no TB transmission from the regions at least during the year of the study.
Isolation of Saccharomyces cerevisiae from pineapple and orange and study of metal’s effectiveness on ethanol production
Authors: Nasir Armanul , Rahman Shafkat Shamim , Hossain Md. Mahboob , Choudhury Naiyyum
Published: February 2017

In view of the anticipated shortage of the traditional supplies of fossil fuels, there is a great deal of interest in the production of ethanol as an alternative biofuel in recent years. The main objective of this research work was to isolate and characterize stress tolerant, high potential ethanol producing yeast strains from various fruit peel. Two yeast isolates from pineapple (Pa) and orange (Or) have been isolated, characterized on the basis of morphological and physic-chemical characters and optimized on ethanol producing capability using sugarcane molasses as substrate. Ethanol production percentage was estimated by Conway method. Isolates were thermotolerant, pH tolerant, ethanol tolerant as well as osmotolerant. They were resistant to Chloramphenicol (30 μg/disc) and Nalidixic acid (30 μg/disc). The isolates showed no killer toxin activity against E. coli. The highest production capacity of the yeasts was found to be 7.39% and 5.02% for Pa and Or, respectively, at pH 5.0, 30 °C temperature in media with an initial reducing sugar concentration of 6.5% for Pa and 5.5% for Or (shaking). Addition of metal ions increased the rate of ethanol production highest to 10.61% by KH2PO4. This study revealed that indigenous yeast isolates could be used to benefit the fuel demand and industrial alcohol industries.
Response to Tyrosine Kinase Inhibitors in Myeloproliferative Neoplasia with 8p11 Translocation and CEP110-FGFR1 Rearrangement
Authors: Wehrli Marc , Oppliger Leibundgut Elisabeth , Gattiker Heinrich H. , Manz Markus G. , Müller Antonia M.S. , Goede Jeroen S.
Published: February 2017

This brief communication reports on a patient with an exceedingly rare “8p11 (eight-p-eleven) myeloproliferative syndrome” (EMS) with CEP110-FGFR1 rearrangement who responded to treatment with the multi-tyrosine kinase inhibitor (TKI) dasatinib. Dasatinib improved quality of life substantially by increasing blood counts and reducing the need for transfusions. This report demonstrates that the second-generation TKI may provide a therapeutic option for elderly and frail EMS patients who cannot be offered aggressive therapy, including allogeneic hematopoietic cell transplantation.
Factors Associated with Early Mortality Among Patients with De Novo Metastatic Breast Cancer: A Population-Based Study
Authors: Vaz-Luis Ines , Lin Nancy U. , Keating Nancy L. , Barry William T. , Winer Eric P. , Freedman Rachel A.
Published: February 2017

Background

Although improvements in survival have been achieved for patients with metastatic breast cancer, some patients experience early death after diagnosis.

Patients and Methods

Using Surveillance, Epidemiology, and End Results data, we identified 26,538 patients with de novo metastatic breast cancer diagnosed between January 1, 2000 and June 30, 2011. We evaluated time trends for deaths at 1 and 6 months after diagnosis. We then restricted the cohort to patients diagnosed between 2010 and 2011 (n = 3,317), when human epidermal growth factor receptor 2 was routinely collected, and examined factors associated with early death.

Results

In 2000, 15.9% of patients died within 1 month of diagnosis and 33.2% within 6 months. In 2011, the proportion of women dying within 1 month decreased to 13.4% and 26.3% within 6 months (p < .001). Older age and uninsured status were associated with early death (at both time points, age ≥70 [versus age <40] had >8.5 higher odds of dying, and uninsured [versus insured] patients had >2.5 higher odds of death). In addition, in some subgroups (e.g., no insurance and triple negative disease), more than half of patients died within 6 months. Region was also associated with early death.

Conclusion

Although we observed improvements in the proportion of patients experiencing early death, one quarter of patients with de novo metastatic disease diagnosed in 2011 died within 6 months of diagnosis. In addition to tumor factors and older age, geography and uninsured status were associated with early death. Our findings highlight the need for focused interventions for metastatic patients at highest risk for poor outcomes.
A Method for Preventing Scarring from Surgical Treatment of Glaucoma
Authors: Zakharova Irina Aleksandrovna , Makhmutov Vladimir Yuryevich , Avdeev Roman Vasil'evich , Varakina Irina Sergeevna , Chernyh Evgeniya Nikolaevna
Published: February 2017

Актуальность Улучшение технических аспектов выполнения хирургических вмешательств при глаукоме позволило до-биться снижения внутриглазного давления в раннем послеоперационном периоде, а также уменьшения частоты развитияпослеоперационных осложнений. Актуальным является вопрос избыточного рубцевания в области оперативного вме-шательства, в результате которого снижается гипотензивный эффект операции, а в отдаленном послеоперационномпериоде, в некоторых случаях, сводит на нет результаты операции.Цель исследования Разработать способ повышения эффективность антиглаукоматозной операции, при которой для про-филактики рубцевания используют синтетический материал Gore-tex.Материалы и методы Эксперимент проведен на 30 животных, которые были разделены на две группы, контрольную - 15животных, оперированных по стандартной методике глубокой склерэктомии по С. Н. Федеорову (ГСЭ), и опытную - 15животных, которым при выполнении ГСЭ под поверхностный склеральный лоскут укладывалась полоска, выкроенная измембраны Gore-tex.Результаты и их обсуждение Исследование результатов имплантации синтетического материала Gore-tex при про-ведении ГСЭ выявило снижение частоты рецидива подъёма внутриглазного давления (ВГД) в позднем послеоперационномпериоде, уменьшение процессов рубцевания. Морфологические исследования показали, что в контрольной группе через 6месяцев в зоне оперативного вмешательства определялось разрастание грубой соединительной ткани с незначительнымколичеством фибробластов и новообразованных сосудов. Уровень внутриглазного давления (ВГД) в контрольной группеживотных через 6 месяцев составил 11.0 мм рт. ст, т. е. вернулся к дооперационному уровню, тогда как в опытной группечерез 6 месяцев после хирургического вмешательства имплант окружен тонкой фиброзной капсулы, вокруг имплантаиме-ется полость до 20 мкм, заполненная жидкостью, которая сообщается с супрахориоидальным и субтеноновым простран-ством. Отмечались дополнительные полости между отдельными волокнами коллагена, также заполненные жидкостью.Уровень ВГД через 6 месяцев после проведения оперативного вмешательства по предлагаемой методике составил 9,0 ммрт ст, что коррелировало с морфологическими изменениями в зоне вмешательства.Заключение Полученные результаты свидетельствуют о том, что использование мембраны Gore-tex снижает процессырубцевания в зоне оперативного вмешательства и способствует повышению гипотензивного эффекта существующегохирургического лечения.Ключевые слова глаукома, профилактика рубцевания, хирургическое лечение.
Forecast Possibilities and Prophylaxis of Surgical Site Infections in TKA
Authors: Alkaz Andrey Vladimirovich , Fadeev E. M. , Linnik S. A. , Kachenko A. N. , Bahtin M. Yu. , Russu I. I.
Published: February 2017

Эндопротезирование коленных суставов (ЭКС) в последние годы занимает особое место среди достижений травматологии и ортопедии [3, 7, 10]. Вместе с тем, эта операция не всегда позволяет добиваться положительных результатов. Осложнения артропластики коленного сустава составляют от 2 до 27% среди всех случаев ЭКС [3, 5, 10, 11]. Структура негативных последствий артропластики коленного сустава (КС) неоднородна [5, 9, 11]. Значительную их часть составляют гнойно-воспалительные осложнения ЭКС [3, 7, 8].В современной отечественной и зарубежной литературе и на научных форумах разного уровня проводятся оживленные дискуссии по вопросам, касающимся улучшения результатов ЭКС. Вместе с тем, данные о возможностях прогнозирования и профилактики гнойно-воспалительных осложнений при артропластике суставов и данные о результатах оказания медицинской помощи при наличии инфекции области хирургического вмешательства (ИОХВ) после эндопротезирования суставов остаются противоречивыми [2, 4, 6]. В связи с этим, изучение вопросов прогнозирования и профилактики ИОХВ при эндопротезировании коленного сустава является актуальной темой медицинских научных исследований.Сохраняющийся риск развития гнойно-воспалительных осложнений при артропластике коленного сустава может быть расценен как побудительный мотив к разработке методик предоперационного планирования и подготовки, вариантов проведения хирургического вмешательства, а также способов ведения послеоперационного периода при эндопротезировании коленного сустава.ЦельНа основании определения факторов риска развития гнойных осложнений в зоне операции и выявления среди больных группы риска, а также разработки и применения алгоритма прогнозирования и профилактики инфекции области хирургического вмешательства улучшить результаты эндопротезирования коленных суставов
Ludzie starzy w „Diagnozie Społecznej”. Warunki i jakość życia w roku 2000 i 2005
Authors: Klima Ewa
Published: February 2017

Zasadniczym celem artykułu jest prześledzenie zmian kondycji gospodarstw domowych emerytów, w oparciu o dane pochodzące z badania „Diagnoza społeczna”. Przedstawiona jest sytuacja z roku 2000 i 2015. Wydaje się bowiem, że przez ostatnie 15 lat również ta grupa społeczna skorzystała z przemian gospodarczych, a deklarowana sytuacja ekonomiczna, w tym warunki życia, znacznie się zmieniły.Dodatkowo, celem artykułu jest wskazanie na znaczenie publikowania w otwartym dostępie danych pierwotnych, a szczególnie wskazanie na komplementarność badań takich, jak „Diagnoza społeczna” w stosunku do badań prowadzonych przez GUS. Wyniki jednoznacznie potwierdzają poprawę sytuacji ekonomicznej i jakości życia emerytów w ciągu ostatnich piętnastu lat. Okazuje się, że nie jest to grupa najuboższa czy najbardziej dotknięta skutkami reform, jak to się powszechnie uważa. Stopień zamożności, mierzony deklarowanymi dochodami i stopień zaspokojenia potrzeb są relatywnie wysokie.Projekt „Diagnoza społeczna” został stworzony, by badać warunki i jakość życia polskiego społeczeństwa. Od samego początku autorzy publikowali nie tylko wyniki, ale i kompletne bazy danych. Daje to innym badaczom nieocenioną możliwość prowadzenia własnych analiz, a jednocześnie uwiarygadnia wnioski zespołu prof. J. Czapińskiego. Wybór zmiennych i obserwacji do dalszej analizy, przy tak dużej bazie, pozostaje jedynie kwestią wyobraźni i potrzeb. Jako atut „Diagnozy” uznać należy jej komplementarność w stosunku do badań GUS-owskich.
Using Social Learning Networks (SLNs) in Higher Education: Edmodo Through the Lenses of Academics
Authors: Durak Gürhan
Published: February 2017

With its total number of users (around 62 million) throughout the world, it is important to determine the views of academics who use Edmodo (the leading SLN. In this respect in the first part of this two-part research, the purpose was to examine academics’ (n=50) use of technology and social networks. As for the purpose of the second part, it was to determine the views of 12 academics—selected from the academics participating in the first part—who had experience in Edmodo about the basic features of Edmodo and about its use in education. In the study carried out with the mixed method, the qualitative and quantitative data were collected with an online questionnaire. The findings obtained were interpreted within the framework of cooperative learning and the theories of “Diffusion of Innovations” and “Uses and Gratifications,” and the related themes were formed. As a result, the academics with experience in Edmodo reported their views about the benefits of use of the Edmodo in education. Regarding the differences between Edmodo and social networks, the results suggested that the former was used completely for educational purposes and that it did not involve any unnecessary components.
Modulation of host’s immune responses and parasite load in Mastomys coucha immunized with recombinant mitochondrial HSP60 of human lymphatic filarial parasite Brugia malayi
Authors: Verma Atul Kumar , Verma Shiv Kumar , Kushwaha Vikas , Verma Richa , Siddiqui Waseem Ahmad , Murthy Puvvada Kalpana
Published: February 2017

Recently we have shown that mitochondrial HSP60 of Brugia malayi (mtHSP60bm) shows high degree of homology with Escherichia coli GroEL/ES and that the ATP binding pockets of HSP60 in humans, E. coli and B. malayi were structurally conserved. In the present study we investigated the immune responses to rmtHSP60bm in Mastomys coucha and the fate of infection in the immunized animals. The animals received 4 immunization doses of rmtHSP60bm and were subsequently exposed to B. malayi infection. Microfilaremia, adult worm status, nitric oxide (NO), Th1 (IFN-g, IL-2) and Th2 (IL-4, IL 10 and TGF-β) cytokine release, cell proliferative response, levels of specific IgG and its subclasses, and the mast cell status in lymph nodes were assessed on day 135/136 post infection. Immunization with rmtHSP60bm and subsequent exposure to infection resulted in significantly high microfilaraemia but without any change in adult worm burden. Immunization with rmtHSP60bm increased IgG, IgG1 and IgG2b levels, and IL-2 and IFN-g release and suppressed NO release and CMI responses, but without any change in IL-4 and IL-10 release. Exposure of immunized animals to infection enhanced the CMI responses and, NO and IL- 10 release but decreased IgG1 levels and IL-2 and IL-4 release; however, IgG, IgG2a, IgG2b, and IFN-g responses remained unaltered. Mast cells in the draining lymph nodes of immunized-infected animals showed significant degranulation but without any increase in cell count. However, no pathology was found in the lymph nodes. These findings indicate that mtHSP60bm may modulate and balance the host’s immune responses to favor parasite survival without inducing any pathology.
Fertilitas Spermatozoa Babi Landrace dalam Pengencer Modifikasi Zorlesco dengan Susu Kacang Kedelai
Authors: Tamoes J A , Nalley W M , Hine T M
Published: February 2017

A research has been done to study the effectiveness of Zorlesco extender and modified Zorlesco extender with soymilk to maintain sperm fertility of landrace boar preserved at 18˚C. Semen was collected twice a week by hand massage from 2 heads of ± 2.5 years old landrace boar. A Completely Randomized Design with 4 treatments and 5 replications was used to organized the experiment. The fresh evaluated semen were extended with zorlesco P(0), zorlesco + hand made soymilk P(1), zorlesco + MetabolisTM soymilk P(2), and zorlesco + MelileaTM soymilk P(3). Extended semen were preserved at 180C. Analysis of variance and Duncan test were used to analyzed data of motility and viability of sperm. The result showed that the modification of diluent Zorlesco added with 5% soymilk could not defend by sperm motility and viability spermatozoa compared with Zorlesco for 42 hours storage (P<0.05).
Keyword: Soymilk, modified zorlesco, sperm motility, sperm viability, landrace boar
Pengaruh perbedaan mikroorganisme dan suhu pada kandungan serat jerami padi fermentasi
Authors: Yanti Y. , Kawamoto Y. , Miyagi T. , Rahmi B. , Surahmanto Surahmanto , Purnomoadi A.
Published: February 2017

The aim of this research was to determine the NDF and ADF content of rice straw
fermented with several types of microorganism at different temperatures. Rice straw was
obtained from rice fields in Ishigaki District, Okinawa, Japan. The types of microbes used
were Lactobacillus fermentum, Bacillus subtilis, Bacillus coagulant Saccharomyces
cerevisiae, and Aspergillus niger. The mainplot was temperature (25, 35, 45°C) and the
subplot was microorganism. Each treatment has 3 replications. There were two groups for
controls, i.e. the control without molasses and the control with molasses. The rice straw
fermented within 3 weeks. The ADF content in all temperature treatments showed that S.
cerevisiae and A. niger treatments were higher (P<0.01) than that in other microorganism
treatments. Hemicellulose content in S. cerevisiae and A. niger were tend to lower (P<0.01)
compare to others microorganism treatments in all temperature treatments. The lowest
hemicelluloses content of fermented rice straw are showed by S. cerevisiae and A. niger at
45°C. These finding suggested that the ADF content were high in S. cerevisiae and A. niger
treatments, but showed decrease in hemicellulose and increase in cellulose and lignin.
Key words: rice straw, fermentation, ADF, NDF
Pengaruh Pemberian Tepung Daun Kayambang (Salvinia molesta) terhadap Bobot Hidup, Persentase Lemak Abdominal dan Profil Lemak Darah Ayam Broiler
Authors: Setiawati, T. , Atmomarsono U. , Dwiloka B.
Published: February 2017

The study aimed to determine the effect of kayambang leaves flour (Salvinia molesta) as a
constituent of broiler ration that contain omega-3 fatty acids, on body weight, percentage of abdominal fat and blood lipid profile including High Density Lipoprotein (HDL) and Low Density Lipropotein (LDL). The material used was 100 broiler chickens unsexied 15 days old with an average a body weight of 500 ± 6.99g. Ration treatment consisted of T0 (ration without Salvinia molesta leaf meal); T1 (ration with Salvinia molesta leaf meal 6 % ); T2 (ration with Salvinia molesta leaf meal 12 %); and T3 (ration with Salvinia molesta leaf meal 18 % ). The results of the study showed Salvinia molesta leaf meal in the ration of broiler chickens affect (P< 0.05) body weight. Treatment T1,T2 and T3 showed decreases compared with the control diet (T0). Abdominal fat percentage showed no significant differences (P <0.05). Increase in LDL from control to treatment and decrease HDL were found in this experiment. The conclusion states that the provision of Salvinia molesta flour up to 18 % decreased the live weight of broiler, but did not decrease abdominal fat percentage. The LDL blood was increased and HDL was decreased due to addition of Salvinia molesta flour.
Key words: Salvinia molesta, broiler chicken, fat, blood
Penggunaan Teknik In Sacco Mobile Sebagai Estimasi Kecernaan Nutrien Hijauan Pakan Ternak di dalam Intestinum
Authors: Hadi Rendi Fathoni , Kustantinah Kustantinah , Hartadi Hari
Published: February 2017

This study aims to explore the potential of forage optimally, the degradation rate of forage nutrients are usually given by the farmers at the time in the intestine of a variety of forage fodder. This study used four kinds of forage feed material: Gliricidia leaves (G), Manilkara leaves (S), Ficus leaves (B) and Cocoa leaves (C). This study was observed in intestinal digestibility. The data taken is nutrient digestibility of rumen and intestinal residues include DM, OM and CP. Samples were incubated in the intestine of cattle that canulation intestine with different time intervals, time/point of incubation: 2, 4, 8, 12, 16, 24, 36 and 48 hours. Samples were incubated in livestock that fistulation intestinal samples of rumen residue. The results showed that the digestibility of nutrients DM, OM and CP respectively forage percentage amount of intestinal digestibility value of feedstuffs in the rumen incubation time of 2-48 hours progressively decreased the percentage of nutrient digestibility. The conclusion of the study when it is time to stay forage in the rumen longer then the more nutrients are degraded by rumen microbes that escapes rumen degradation will be more and more and can be digested in the intestine will be less.

 Keywords: in sacco mobile, forage, intestine
KEBIJAKAN JAMINAN SOSIAL TENAGA KERJA SEKTOR INFORMAL BERBASIS KEADILAN SOSIAL UNTUK MENINGKATKAN KESEJAHTERAAN
Authors: , Siti Ummu Adillah , , Sri Anik
Published: February 2017

Abstracts

 The implementation of social security programs for informal sector workers is a priority for labor outside the employment relationship is dominated workforce in Indonesia. Implementation of this program, there are still barriers include: lack of cooperation between the Social Security Agency (BPJS)  Employment
employment, while on the side of labor, namely payment of dues and the amount of the payment of compensation that do not correspond to the level of workplace accidents.

Keywords : Policy, the Social Security Employment Agency, informal sector

 Abstrak

Penyelenggaraan program jaminan sosial bagi tenaga sektor informal menjadi prioritas karena tenaga kerja diluar hubungan kerja ini mendominasi angkatan kerja di Indonesia. Pelaksanaan program ini masih terdapat hambatan-hambatan antara lain: kurangnya kerjasama antara Badan Penyelenggara Jaminan Sosial (BPJS) Ketenagakerjaan dengan pihak tenaga kerja sektor informal, kurangnya sosialisasi, sulitnya menghubungi dan menelusuri keberadaan tenaga kerja mandiri, sedangkan dari sisi tenaga kerja yaitu pembayaran iuran dan jumlah pembayaran santunan yang tidak sesuai dengan tingkat kecelakaan kerja.

Kata Kunci: Kebijakan, Jaminan Sosial Tenaga Kerja, Sektor Informal

 