bluuebunny/crossref_metadata_2025 huggingface dataset:
POSTAWY SPOŁECZNE MŁODZIEŻY W KRAJACH PO OBU STRONACH WSCHODNIEJ GRANICY UE WOBEC OSÓB Z OGRANICZONĄ MOBILNOŚCIĄ W OBLICZU KONSEKWENCJI WOJNY W UKRAINIE
Authors: Szpakow Andriej , Kowalewska Beata , Vilchynskaya Liudmila
Published: September 2024

Wstęp: Uwzględniając fakt, że wojna w Ukrainie i jej następstwa dla zdrowia i życia to sytuacja, która w sposób znaczący dotyka i dotknie wielu ludzi, w najbliższej przyszłości można przewidzieć wzrost liczby osób z dysfunkcją układu ruchu. Ważnym aspektem w postrzeganiu osób z niepełnosprawnością ruchową jest kształtowanie pozytywnych postaw społecznych. Cel: Określenie postaw młodzieży studenckiej (800-1000 respondentów z dziesięciu państw wzdłuż granicy wschodniej UE) wobec osób poruszających się na wózkach inwalidzkich. Powyższą tematyką udało się zainteresować naukowców z Polski, Litwy, Białorusi, Ukrainy, Słowacji, Czech, Serbii, Czarnogóry, Turcji i Kazachstanu zajmujących się badaniami epidemiologicznymi zjawisk społecznych, tworząc międzynarodowy zespół badawczy, co pozwoliło na przeprowadzenie badań wkrótkim czasie. Jako narzędzie wykorzystany został standaryzowany kwestionariusz wielojęzykowyThe Multidimensional Attitudes ScaleToward PersonsWith Disabilities (MAS).W trakcie realizacji badania zwrócono uwagę na emocjonalne, poznawcze i behawioralne komponenty postaw. Wynik globalnego MAS był zbliżony w badanych państwach do typowego dla populacji (80,2±17,80, Me=81, min-maks. = 34-162). Odpowiedzi objętych badanem studentów często pokazywały postawę niezdecydowaną, a nawet negatywną. Wykazano, że sytuacje kryzysowe mogą wpływać na postawy społeczne i być czynnikiem, który sprzyja empatii i pozytywnym postawom wobec osób potrzebujących wsparcia. Grupa studentów ukraińskich, którzy odczuli skutki działań zbrojnych wykazywała bardziej pozytywne postawy wobec osób z niepełnosprawnością ruchową. Rezultaty mogą być wykorzystane zarówno do analizy postaw indywidualnych, jak i grupowych w poszczególnych krajach oraz do opracowania rekomendacji praktycznych. Badanie pozwala również na analizę skuteczności i ewaluację działań ukierunkowanych na podnoszenie świadomości społecznej i kształtowanie postaw wobec osób z niepełnosprawnością.
HOW AI CAN SUPPORT FOLLICULAR LYMPHOMA DIAGNOSIS
Authors: Świderska-Chadaj Żaneta , Krawczyk Adam , Pakuło Sławomir , Osowska-Kurczab Aleksandra , Kotłowski Wojciech
Published: September 2024

The field of medicine is witnessing a significant integration of Artificial Intelligence (AI) technologies. Novel Computer-Aided Design (CAD) methods are emerging as valuable tools to support pathologists, easing their workload and reducing operational costs.Yet, the creation of specialized solutions tailored to specific tasks, such as aiding in the diagnosis of Follicular Lymphoma (FL), faces hindrances including data collection and annotation challenges. In response to the intricate demands of pathologists’ tasks, we propose an AI-driven approach for detecting centrocytes (CBs) and centroblasts (CCs) in FL cases. Notably, identifying centroblasts poses a noteworthy challenge, even for experienced professionals, due to potential confusion with centrocytes. Our method is devised to identify cells and assign them into three distinct categories: centroblasts, centrocytes or other. While existing studies predominantly concentrate on centroblast detection, our investigation extends to evaluating its effectiveness in categorizing centroblasts against non-centroblast cells—encompassing centrocytes and other classes—aligning with configurations outlined in current literature. Under this specific setup, we achieved an F1-score, precision, and recall of 63%. Our exploration into centroblast detection using the proposed approach highlights the practicality of detecting centroblasts within whole slide images (WSIs) scanned at x20 resolution. Despite leveraging lower-resolution images, we have showcased the ability to achieve centroblast classification results. Looking ahead, the proposed algorithm holds potential for extension to support follicular lymphoma grading.
HUMANITY: THE MEANING OF WHAT TO DO
Authors:   International Engineering Academy, Moscow, Russia, Tarkhanov Oleg V.
Published: September 2024

The article, based on the logic of Aristotle and Hegel, studies the path of humanity from savagery to its modern forms. It is shown that the formation of human communities was determined by methods of obtaining food, the highest form of which was agriculture. It was revealed that the development of communities was accompanied by crises, the cause of which was unrecognized by people in the methods of obtaining food. At the heart of the modern crisis of society lies the erroneous theory of mineral fertility, the application of which leads to the destruction of natural fertility, to famine and a worldwide war for the remnants of fertile land. The crisis can be overcome by replacing it with the naturally formed cycle of four forms of organic matter, discovered in the USSR.
ANALYSIS OF INDUSTRY ANISOTROPY IN INTERNATIONAL MECHANICAL ENGINEERING
Authors:   The Kosygin State University of Russia, Moscow, Russia, Silakov Alexey V. , Ternova Yaroslavna O. ,   The Kosygin State University of Russia, Moscow, Russia, Kharebov Konstantin V. ,   National Research Centre «Kurchatov Institute», Moscow, Russia
Published: September 2024

Industry anisotropy, including in international mechanical engineering, is a poorly studied property of the industry system. At the same time, it is anisotropy that determines the nature of intra-industry competition. The aim of the study is to propose an approach for the analysis of industry anisotropy in the coordinate space “ resilience – efficiency” where a two–petalled R-lens will be formed, which is then clustered, with the allocation of seven reference clusters. The inclusion of such enterprise image points in one of the six selected clusters allows companies from the industry to assess their location, nearest competitors, risks, and methods of repositioning (if applicable). The study is original, it uses methods of fuzzy set theory and soft computing. A new technology for analyzing industry anisotropy based on clustering of R-lenses is proposed.
ENERGY INTENSITY OF THE GERMAN INDUSTRY: THE STATE IN THE CONTEXT OF A DIFFICULT MACROECONOMIC SETTING
Authors:   National Research University «MPEI», Moscow, Russia, Laznik Anatoly A. , Musikhin Vladislav I. ,   TES LLC, Moscow, Russia
Published: September 2024

Energy-intensive industries are of particular importance for the German economy, but due to global geopolitical uncertainty and the consequences of the crisis caused by coronavirus infection, they have been facing increasing costs, lack of resources, and reduced demand in the past few years. The purpose of the study is to analyze the state of industries in modern conditions, as well as the high volatility of energy prices. In many ways, the decline in the competitiveness of enterprises in the short term is explained by the lack of cost savings. However, the general decline in jobs and the decline in industrial activity point to more significant structural problems, indicating the ambiguity of the prospects for industries within the framework of an open economy.
INDUSTRY ANISOTROPY ANALYSIS IN INTERNATIONAL LIGHT INDUSTRY
Authors:   National Research Centre «Kurchatov Institute», Moscow, Russia, Kharebov Konstantin V.
Published: September 2024

In the interests of strategic positioning of enterprises and in order to ensure conditions for their effective competition, it is necessary to clarify the enterprise’s place on the industry map in the “resilience – efficiency” coordinates. Such clarification is possible when studying a new property of sectoral anisotropy. Using the example of international light industry, we show that all enterprises in the industry can be divided into three large classes: “pioneers”, “miners” and “convoys”, with each class dominating each other in the Pareto sense. The current positioning of the enterprise involves clarifying the layer in which it is located, as well as the list of its closest competitors, highlighting the strengths and weaknesses of the company under study. During anisotropy analysis, methods of fuzzy set theory and soft computing are used, including obtaining an industry stability zone in the form of an R-lens.
DEVELOPMENT OF BUSINESS PROCESSES IN THE CONTROLLING SYSTEM
Authors:   Federal State Educational Institution of Higher Education “Financial University under the Government of the Russian Federation”, Moscow, Russia, Balyshina Polina V. , Lipatova Inna V. ,   Federal State Educational Institution of Higher Education “Financial University under the Government of the Russian Federation”, Moscow, Russia
Published: September 2024

The vector of digital transformation set by the President of Russia is aimed primarily at a deep reorganization of the public administration system, affecting all spheres of social and economic policy of the state. Digital transformation, first of all, will allow us to build a process approach to strategic goal-setting for the implementation of business processes, which will directly affect the improvement of the quality of management decisions at all levels of government.
THE ROLE OF RELATIONAL MARKETING IN THE MANAGEMENT SYSTEM OF AN ENTREPRENEURIAL STRUCTURE
Authors:   Saint-Petersburg State University of Aerospace Instrumentation, St. Petersburg, Russia, Rudakova Lidiya V.
Published: September 2024

The article highlights and substantiates the role of relational marketing in the management system of an entrepreneurial structure. Three main approaches to relational marketing are analyzed and justified: North American, European and Scandinavian, which allowed us to define relational marketing and see its new dimension through customer relationship management (CRM) and customer experience management (CEM). The scientific novelty and practical significance of the work lies in identifying the success factors of relational marketing: long-term orientation, reciprocity, reliability, information exchange, flexibility, conflict resolution, moderate impact on the client, which contribute to the management systems of business structures to improve the organization of their client-oriented strategy.
ON THE ISSUE OF THE EFFECTIVENESS OF INTERNAL MARKETING IN SERVICE SECTOR ORGANIZATIONS
Authors:   Federal State Budgetary Educational Institution of Higher Education “Novosibirsk State University of Economics and Management “NINH”, Novosibirsk, Russia, Shadrina Lyubov Yu.
Published: September 2024

The article is devoted to the study of the role of internal marketing as a key tool for human capital management in the context of growing competition in the service market. The article analyzes the existing tools for evaluating internal marketing, as well as the practice of its application in small and medium-sized businesses. The conducted qualitative research, based on semi-structured interviews with representatives of 21 organizations, allows us to identify the main indicators of the effectiveness of internal marketing, such as employee satisfaction and engagement, and the level of internal communication. The author offers an innovative evaluation model focusing on the needs of employees. Recommendations on the implementation of internal marketing tools are aimed at increasing employee motivation, improving the quality of customer service and achieving corporate goals.
Seasonal occurrence of the shoot fly complex on Rabi sorghum in the Marathwada area of Maharashtra
Authors: Meena Sharad Kumar , Bhamare Vijay Krishnrao
Published: September 2024

The present study was conducted to investigate the variety and abundance of shoot flies in the Postgraduate Experimental Field, Department of Agricultural Entomology, College of Agriculture, Latur Campus, Maharashtra, India, during rabi season 2020-21. Analysis of insect pest population dynamics indicated that Atherigona soccata attained its maximum population density during the 51st standard meteorological week, with an average of 3.60 maggots per quadrat. Correlation studies exhibited that wind speed had a detrimental impact on the population of A soccata maggots. During the first sampling period of the study, Oscinella sp. achieved its peak population density, with an average of 13.00 maggots per quadrat. Link tests revealed a positive link between the relative humidity before noon and the population of Oscinella sp., but a substantial negative correlation was seen between wind speed and the population. The population of Ectecephala sp. reached its highest level during the second sampling week, with an average of 2.33 maggots per quadrat. Correlation studies demonstrated a substantial negative correlation between wind speed and the population of Ectecephala sp.
Effect of magnetic and electric treatments on growth, yield and seedling parameters of chickpea (Cicer arietinum L.)
Authors: Bhavani Lankada Lakshmi , Dayal Abhinav
Published: September 2024

The objective of this work was to investigate the impact of electric current and magnetic field to the growth, yield, and seedling characteristics of chickpea by examining the response of chickpea to magnetic and electric treatments of varying intensities and durations. The ICC 30-70 seeds were obtained from the Department of Genetics and Plant Breeding and subjected to treatments involving AC magnetic flux intensities ranging from 75 mT to 125 mT for 3 and 5 minutes in the magnetic field, as well as AC electric current ranging from 75 mA to 125 mA for 30, 60, and 90 seconds treatments, separated by equal rest periods. Throughout the study, statistically significant differences were found in field emergence (84.30%), leaf area (8.62cm2), plant height (35.60cm), biological yield (10.70gm), number of pods per plant (30), and total yield per plot (118.67gm). Within the seedling parameters, all treated seeds exhibited the highest germination percentage compared to the control. Additionally, there was a favorable impact on seedling length (27.85cm), fresh weight (0.74gm), dry weight (0.30gm), and vigour indices I (2683) and II (28.71) following the seed treatment. The present study leads to the conclusion that the magnetic and electric treatments shown superior performance when compared to the control. Throughout the investigation, it was noted that the application of magnetic and electric treatments positively influenced the vegetative growth of plants. Furthermore, the dry matter partitioning showed a substantial rise in seeds treated with electric current, leading to a higher yield-per plot.
Molluskicidal activity of synthetic organic compounds (on the foot of Achatina fulica (Bowdich)
Authors: Jadhav Kirti , Bhalla Resham
Published: September 2024

Terrestrial snails are economically destructive agricultural pests that cause great damage to vegetables and crops. The present study was performed to evaluate the toxicity of synthetic organic derivatives and subsequent histopathological alterations in the feet of Achatina fulica (Bowdich) after exposure to (E)-1-(4-bromophenyl)-3-(4-methylthiazole-5-yl) prop-2-en-1. Accordingly, the LC50 of the synthetic organic derivative was determined to be 1.4206±0.0981. These chemicals can easily penetrate the body of mollusks either by feeding or crawling on the surface, and the foot is the first point of contact. Histopathological and ultrastructural alterations were observed in the foot of Achatina fulica (Bowdich), as these organs play important roles in locomotion and mucus secretion. These alterations include degeneration of the normal structure of the cell by rupturing of the outer protecting membrane, and a large gap is created between the cells. The longitudinal muscle band is destroyed by increasing the space. These results are important from an economic point of view since these synthetic chemical compounds were used as molluskicdes for the control of Achatina fulica (Bowdich), which is an agricultural pest.
Argyreia pilosa Wight & Arn.: An addition to the flora of Nashik district, Maharashtra, India
Authors: Kale Balasaheb , Khairnar Sanjay Appaji , Sabale Suresh Ganpat
Published: September 2024

Within the northern Western Ghats of Maharashtra, Nashik district stands out as the most ecologically diverse region. It is situated within the latitudes of 19° 59' 50.8344'' N and 73° 47' 23.2908'' E. Locally, several plant taxa remain unexplored. This study aims to investigate the floristic diversity and various taxonomic groups of angiosperms present in unreported taxonomic groups within the examined region. During the botanical study in the northern Western Ghats of Nashik locations, we examined the critically endangered morning glory (Argyreia pilosa Wight & Arn.) flowering plant species, which was found in the concentrated region. This botanical investigation involved the collection of plant taxa from diverse regions and ecosystems, marking the first instance of similar collection. The scientific study conducted by the author uncovers novel data about Argyreia pilosa Wight & Arn. in the Nashik district of the northern Western Ghats of Maharashtra.
Histological investigation of the liver of freshwater fish Cyprinus carpio after intoxication with Ibuprofen
Authors: Rani Rekha , Neeraj Surya Prakash , Garg Suyash
Published: September 2024

Water contamination has a detrimental impact on streams and rivers, leading to a reduction in the diversity of terrestrial, aquatic, and aerial species. Furthermore, it disrupts the intricate equilibrium of existence. Pharmaceuticals are artificial compounds that belong to several chemical families and exhibit a diverse array of environmental biochemical responses, rendering them the most recent group of pollutants in all aquatic environments. The present study investigated the impact of Ibuprofen on freshwater fish Cyprinus carpio by determining the LC50 value of Ibuprofen during exposure to various concentrations for 24, 48, 72, and 96 hours in sets of aquariums at a concentration of 0.23ml/L. To investigate the impact of Ibuprofen on fish C. carpio, the study evaluates the effects of a sublethal concentration of 1/10th (0.023ml/L) of Ibuprofen LC50 on fish liver histology over a period of 7, 14, 21, and 28 days in both control and treatment aquarium cultures. Following exposure to a sublethal dose of Ibuprofen, significant changes in the behavior of fish and disruption of normal physiology were observed. These changes were clearly displayed through nuclear degeneration, cellular edema, cytoplasmic degeneration, altered hepatocytes, formation of vacuole, increased sinusoidal space, altered central vein, and degeneration of sinusoid. These results indicated that the release of pharmaceuticals had a significant negative impact on fish health and highlighted deterioration in water quality and the ecology of water resources .
Advancing disaster management through biofuel integration: A comprehensive review
Authors: Karmakar Rachan , Tripathi Vijay , Sharma Pradeep Kumar , Bhattacharya Sourish , Singh Narpinder , Naithani Suman
Published: September 2024

Scientific evidence has demonstrated that biofuels have the ability to reduce environmental contamination, hence addressing the underlying causes of potential disasters. Renewable fuels produced from biological resources provide flexible solutions for several aspects of crisis management, such as supplying energy for emergency generators, fuelling transportation fleets, and offering heating and cooking options. Empirical evidence supports the notion that biofuels effectively reduce carbon and sulphur emissions. Notably, certain biofuels, such as algal biodiesel, have the capacity to mitigate 0.6% of carbon dioxide output. Cities, such as Delhi, that are contaminated by the consumption of fossil fuels have a scarcity of breathing oxygen during the winter and elevated ambient temperatures during the summer. These pioneers cause inundation and tempests in vulnerable regions. The lessons acquired from various locations highlight the importance of cooperation, enhancing capabilities, and providing governmental support in order to replicate and expand successful models. To optimize the advantages of biofuels in crisis management, it is crucial to prioritize research and development projects, involve stakeholders, and raise awareness. The role of national and international policy is vital in providing incentives for the production and use of biofuels, while technical advancements are key in shaping the future of sustainability and efficiency. Communities may utilize the ideas of sustainability and resilience to leverage the transformational potential of biofuels in order to construct societies that are safer, more environmentally friendly, and better equipped to withstand challenges.
Production of nutritionally active compounds from Spirulina platensis under various stress conditions
Authors: Kushwaha Jyoti Singh , Sharma Rita , Dwivedi Kuldip
Published: September 2024

The free-floating, filamentous cyanobacteria Spirulina platensis is highly valued and in great demand worldwide for its high-value colors and phytonutrients. These compounds find use in health foods, feed, medicines, and diagnostics. The primary objective of this work was to enhance the growth of Spirulina under both oxidative and physiological stress conditions in order to maximize the synthesis of phycocyanin and carotenoid pigments. Cultures were subjected to different concentrations of hydrogen peroxide (H2O2) and sodium chloride for varying temperatures and pH levels. Under lower concentrations of H2O2 (4mM), the maximum carotenoid content was increased, but the phycocyanin content was found to be stimulated at 10mM. Moreover, the synthesis of both pigments was shown to be highest under physiological stress circumstances (40mM and 60mM NaCl concentration) and at an optimal pH of 8-9, helped by a temperature range of 25-30℃. The experimental results demonstrate that both carotenoid and phycocyanin exhibit antioxidant properties even in the presence of oxidative stress. This suggests that the aforementioned circumstances can be applied in future investigations to extract different antioxidants from S. platensis.
Polymer precursor method for the synthesis of zinc oxide nanoparticles: A novel approach
Authors: Kumar Rajesh , Singh Bhoj Gaurav , Chandra Arya Mahesh , Karmakar Rachan , Sharma Pradeep Kumar , Tripathi Vijay
Published: September 2024

This study presents a novel approach to synthesize zinc oxide (ZnO) nanoparticles using a polymer precursor method, offering precise control over particle size in the nanometer scale. Zinc oxide nanoparticles are of significant interest due to their wide-ranging applications in various fields such as solar cells, gas sensors, photocatalysts, and nanomedicines. The synthesized nanoparticles were thoroughly characterized using X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), and Fourier Transform Infrared spectroscopy (FTIR). The distinct hexagonal form detected in the XRD pattern, featuring characteristic reflection planes at angles of 31.72° (100), 34.39° (002), 36.23° (101), and 47.44° (102), signifies the synthesis of ZnO possessing a hexagonal wurtzite structure. The SEM and TEM images revealed uniformly spherical particles with an average size ranging from 35 to 40 nm. Such uniform morphology and size distribution are critical for ensuring consistent performance in applications such as gas sensing and catalysis. Additionally, the FTIR spectra indicated a reduction in impurities after the synthesis process, highlighting the effectiveness of the polymer precursor method in producing high-quality ZnO nanoparticles. Heating the ZnO precursor material at 400°C for 2 hours significantly reduces impurities, suggesting conversion to ZnO nanoparticles.
Characterization of species structure and regeneration patterns under different density gradients in a tropical Sal forest of Achanakmar-Amarkantak biosphere reserve in Central India
Authors: Singh Samyak , Dixit Bhavana , Prajapati Lata , Chandrakar Shishir , Tamrakar Aakriti
Published: September 2024

Understanding disturbances that are of significant significance requires a critical focus on preventing forest degradation and addressing problems related to vegetation loss. Hence, the primary objective of this work was to examine the structure of species and the patterns of regeneration at various density gradients within the Achanakmar-Amarkantak Biosphere Reserve in India. This study involved the selection of one closed site (CS) and one open site (OS) from both the Mixed Sal Forest (MSF) and the Pure Sal Forest (PSF). In order to ascertain population structure and regeneration status, plants were classified into seedlings, saplings, and adults based on their Girth at breast height (GBH). The results of our study revealed that the population density of seedlings, saplings, and trees was higher in MSFCS (49250, 980, and 920 ind/ha) compared to PSFCS (41500, 740, 890 ind/ha), MSFOS (16750, 580, and 370 individuals ind/ha), and PSFOS (9750, 180, and 334 ind/ha). Both forests exhibited a reverse-J shaped curve in the CS and an interrupted reverse-J shaped curve in the OS of overall tree species. Nevertheless, the distribution curve at the species level displayed diverse patterns. For instance, Shorea robusta displayed irregular shapes in the OS of both forests, while Terminalia tomentosa displayed a bell-shaped GBH density distribution population curve across all the sites. Differences in regeneration status were observed among different tree species. At the four sites, 18.75% of the species showed good regeneration, 21.87% showed fair regeneration, and a substantial portion, 35.94%, displayed poor to no regeneration. Additionally, 23.44% of the species showed new regeneration. Among these species, Diospyros melanoxylon and Syzygium cumini showed strong regeneration capabilities, while Shorea robusta shown moderate regeneration potential. In the future, the population structure, dominance, and richness of the present tree community may undergo changes. Hence, it is imperative to conduct study on the survival of seedlings and use appropriate management techniques in order to guarantee the long-term viability of the forests.
In silico approach to identify the potential targets of Alexidine dihydrochloride and Hexachlorophene in human fungal pathogen C. glabrata
Authors: Ansari Ayesha , Kumar Darshan , Rai Nishant , Kumar Navin
Published: September 2024

Widespread usage of antifungals has led to the development of antifungal resistance, causing a change in the epidemiology of the responsible agents from albicans to non-Candida albicans species. Pharmaceutical repurposing is an alternate strategy that has provided a cost-effective method to address the increasing resistance to antifungal medications. The objective of this work was to examine the antifungal properties of Alexidine dihydrochloride (AXD) and Hexachlorophene (HCP) against a non-Albicans Candida model, C. glabrata. The lowest inhibitory doses of AXD and HCP against C. glabrata were determined by in vitro methods to be 0.69-1.03 µM and 14.75-19.66 µM, respectively. The minimum doses of AXD and HCP that caused fungicidal effects were defined as 1.375 µM and 61.44 µM, respectively. Three proteins involved in crucial physiological pathways, namely cell wall production (Kre1p, Kre2p, Ecm33p), membrane calcium channel (Mid1p, Ecm7p), and ergosterol biosynthesis (Erg5p), were chosen as potential targets for the medications due to their functions in survival and disease development. SWISS MODEL was used to create the 3D structures of predicted targets of C. glabrata. The quality of these structures was assessed using Ramachandran plot statistics. AXD and HCP were analyzed by docking software AutoDock Vina against these targets. The findings of computational investigations have shown that both medicines exhibit interaction affinities with all the selected protein types. The binding energy profiles of AXD and HCP showed that Mid1p had the lowest binding energies at -10.1 kcal/mol and -9.2 kcal/mol, respectively. Kre2p had binding energies of -7.9 kcal/mol and -7.1 kcal/mol, respectively. Erg5p had binding energies of -6.6 kcal/mol and -6.2 kcal/mol, respectively. Ecm7p had binding energies of -6.6 kcal/mol and -6.1 kcal/mol, respectively. Recm7p had binding energies of -4.8 kcal/mol and -7.7 kcal/mol, respectively. These results suggest that these genes are likely targets of the two drugs in C. glabrata.
Unravelling novel molecular targets of Thymol and Carvacrol in Candida glabrata
Authors: Kumar Darshan , Ansari Ayesha , Rai Nishant , Kumar Navin
Published: September 2024

The emergence of non-albicans Candida as a potential causative agent of candidiasis following Candida albicans is occurring globally. It is known that phenolic cresols, thymol, and carvacrol have anti-Candida characteristics. However, there are few papers that disclose the mechanism of action, which is characterized by a damaged cell wall and ergosterol synthesis, as well as calcium-induced death in C. albicans. This work utilized in-silico docking analysis to examine the molecular targets of thymol and carvacrol in Candida glabrata. The results were then validated in vitro by antifungal susceptibility testing and growth curve analysis. The study incorporated C. glabrata deletion mutants for the target proteins to gain understanding of the function of these proteins in the antifungal effects of the two monoterpenoids. After conducting molecular docking and in silico toxicity evaluations, thymol and carvacrol were chosen for in vitro investigations. Experimental tests conducted in a laboratory setting have shown that both phytocompounds exhibit strong binding affinity towards cell wall synthesis proteins (Kre1p, Kre2p, Ecm33p), calcium channel proteins (Mid1p, Ecm7p), and proteins involved in the ergosterol synthesis pathway (Erg5p). These proteins are likely to be the specific targets for the anti-Candida properties of the two isomeric monoterpenoids in C. glabrata. Minimum inhibitory concentration (MIC50) values for thymol and carvacrol range from 50 µg/ml to 75 µg/ml. The wild-type strains exhibit a minimum fungicidal concentration of 100 µg/ml for thymol and 125 µg/ml for carvacrol. The results underscore the significance of these proteins in the fungal reaction to thymol and carvacrol and also indicate a promising opportunity for the development of novel antifungal treatment methods utilizing these proteins.
Ashwagandha's (Withania somnifera) potential effects on growth, intestinal histomorphology, and antioxidant enzyme activity in fingerlings of Catla catla (Hamilton, 1822)
Authors: Thayes Chhomo , Chauhan Sidharth , Ali Basharat , Rawal Yogesh Kumar
Published: September 2024

The present work aims to examine the impact of Ashwagandha (Withania somnifera) on the developmental trajectory of Catla catla fingerlings. A 90-day feeding experiment was carried out using various concentrations of Ashwagandha, with T0 (0%) serving as the control and T1 (2%), T2 (4%), T3 (6%), and T4 (8%). At the conclusion of the trial period, the T3 (6%) group showed a significant (p < 0.05) improvement in growth indices including Specific Growth Rate, Feed Conversion Efficiency, and Protein Efficiency Ratio. The intestinal histomorphology of all therapy groups was consistently normal, with no pathological abnormalities. In contrast to the control, the T3 (6%) group exhibited a more pronounced enhancement in villi parameters, particularly in terms of villi height and width. The excretion of orthophosphate (O-PO4) and ammonia (N-NH4) exhibited a uniform pattern in all treatment groups, with relatively low excretion seen in the T3 (6%) group. Post-feeding, the T0 (0%) group had the greatest excretion of ammonia and orthophosphate compared to the groups fed Ashwagandha-supplemented meals. Furthermore, those fed with Ashwagandha showed significantly (p < 0.05) increased activity of several antioxidant enzymes, including Superoxide Dismutase (SOD), Catalase (CAT), Glutathione S-Transferases (GST), and Reduced Glutathione (GSH), compared to the control. These findings highlight the capacity of Ashwagandha as a dietary supplement to enhance the general health performance of Catla catla fingerlings in aquaculture.
Exploring the bioactive potential and safety profile of Caesalpinia decapetala seeds and seed oil
Authors: Ashagrie Yenework Nigussie , Tadesse Mesfin Getachew , Bachheti Rakesh Kumar , Bachheti Archana , Tyagi Manjusha , Rai Nishant
Published: September 2024

The rationale for this work was to investigate the phytoconstituents of the Caesalpinia decapetala species and their possible antibacterial and antioxidant capabilities, based on their traditional use in treating conditions such as inflammation, diabetes, purgative, and bronchitis. Analysis of the C. decapetala seed identified phytoconstituents such as flavonoids, alkaloids, phenolics, glycosides, saponins, proteins, terpenoids, and triterpenoids. The quantitative analysis revealed that the phenolic content of C. decapetala seed was greater than that of the seed oil (889 ± 0.35 mg GAE/100g of dry weight). Additionally, the total flavonoid content of the seed was estimated to be higher than that of the seed oil (225.03 ± 7.13mg QE/100g of dry weight). Furthermore, the seed of C. decapetala contained 11.5813% ± 0.242 of the total alkaloid contents. The antioxidant activity of the seed oil was investigated using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH), ferric reducing power, and 2,2-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS) techniques. The measured IC50 value for DPPH was 114.86 µg/mL, while for ABTS it was 138.45µg/mL. Seed oil exhibited a more pronounced zone of inhibition in its antibacterial activity against K. pneumoniae. Overall, the present investigation validates that the seed and seed oil of C. decapetala have the potential to serve as a valuable reservoir of minerals, antioxidants, and antibacterial properties. This is due to the presence of diverse phytoconstituents, including phenolic compounds, flavonoids, alkaloids, di-α-tocopherol, stigmasterol, γ-sitosterol, and lupeol, within its fatty acid composition.
Managing Seasonal Vaccination Campaigns: a Comprehensive Critical Review
Authors:   Hazazi Abdulrahman Yahya, AL Ahmadi Alaa Muhammed, AL Enizy Fawaz Farhan, AL Sharif Mohammed Shahhat, AL Sobhi Ahmed Ateaqallah, AL Mutairi Mohammed Sahw Hazim  and AL Anazi Mahdi Suleman
Published: September 2024

Seasonal vaccination campaigns are critical for controlling outbreaks of infectious diseases such as influenza and pneumonia. This comprehensive critical review examines the strategies, challenges, and best practices in managing these campaigns. The review explores the entire process, from planning and preparation to implementation and evaluation, highlighting the importance of effective stakeholder engagement, supply chain management, and public awareness. Innovative solutions to common challenges, such as vaccine hesitancy and logistical constraints, are discussed. Detailed case studies of successful campaigns provide practical insights and lessons learned. Emerging trends and technologies, including digital health tools and new vaccine formulations, are also explored. The findings emphasize the need for continuous improvement through robust monitoring and evaluation mechanisms. This review offers valuable recommendations for policymakers and healthcare practitioners to enhance the effectiveness of seasonal vaccination campaigns, ultimately contributing to improved public health outcomes.
Service Enhancement Strategies for Pharmacy, Laboratory, and Nursing Departments: A Systematic Review
Authors:   AL Shammari Faten Hamoud, AL Dilh Sara Mahdi Swaid, AL Rehaili Abdulaziz Ajal, AL Arjani Maram Nawaf, AL Mutairi Hamoud Zayed, AL Mutairi Salma Salem and AL Dossary Bashayer Draan
Published: September 2024

This systematic review explores service enhancement strategies in three critical supporting health departments: pharmacy, laboratory, and nursing. These departments play a crucial role in ensuring high-quality healthcare delivery, yet they often face challenges that can impede efficiency and patient outcomes. The review identifies and analyzes various strategies, such as process automation, technology integration, workflow optimization, and staff empowerment, that have been implemented to improve service quality in these departments. Key findings reveal that enhanced pharmacy services can reduce medication errors and improve inventory management, while laboratory improvements can lead to faster diagnostics and more accurate results. In the nursing department, better staff ratios, decision-making tools, and health informatics have shown promise in increasing patient care quality. This review highlights the positive impact of service enhancements on patient safety, satisfaction, and operational efficiency while discussing challenges in implementation and the need for future research to address these gaps.
Enhancing Healthcare Through Early drug allergy Detection: A Systematic Review
Authors:   AL Mutairy Khaled Ayed, Hazazi Abdulrahman Yahya, AL Harthi Ayidh Saad, AL Sulami Khalid Azizallah Abdulaziz, Asiri Amjad Matuq Abdullah and AL Knani Mutaz Ismil
Published: September 2024

Drug allergies are a significant cause of adverse drug reactions (ADRs), affecting patient safety and healthcare outcomes. Early detection of drug allergies is crucial for preventing these reactions and improving clinical care. This systematic review explores the current methods of early drug allergy detection, including patient history, skin testing, in vitro tests, and emerging genomic approaches. Findings indicate that accurate early identification of drug allergies, particularly with the use of skin testing and electronic health records (EHR)-based alerts, reduces the likelihood of adverse reactions and unnecessary drug avoidance. In vitro testing, including drug-specific IgE and basophil activation tests, provides non-invasive alternatives, while pharmacogenomic data show promise for predicting hypersensitivity in the future. The review emphasizes the importance of integrating detection methods into healthcare systems to enhance medication safety, lower healthcare costs, and improve patient outcomes. However, challenges remain, such as mislabeling allergies, limited access to testing in some settings, and the need for standardized protocols. Further research is recommended to develop more accessible testing methods and explore the long-term impact of early drug allergy detection on healthcare systems.
Introduction to Homological Algebra for Quantaloids: Semisimple Modules over a Quantaloid
Authors: Benkhadra Arij , Benkhadra Dirar
Published: September 2024

This paper is a step towards a homological classification of quantales and quantaloids by characterizing semisimple quantales and quantaloids via their modules. We prove that semisimple quantales and quantaloids are quite similar to semisimple rings via their homological dimensions. More precisely, we study simple and semisimple modules and we connect them to the notions of artianity and noetherianity. We proved that simple modules are cyclic, establishing a connection with maximal congruences. Furthermore, we demonstrated that the structure of semisimple quantaloid modules closely resembles that of semisimple modules over a ring. Specifically, the ascending and descending chain conditions coincide, along with the occurrence of split short exact sequences and other related properties.
A Mathematical Fuzzy Transform for Evaluating the Effect of Recombi Nant on Growth Hormone
Authors: Harif B. Mohamed , Karthikeyan M.
Published: September 2024

The fuzzy transform (FT) is a novel, extensively utilized soft computing method with solid mathematical underpinnings. This article presents the technique using data on plasma levels of Interleukin-6, which is indicative of low-grade inflammation or severe activity. We first show how useful it is for describing and identifying attribute dependencies. Moreover, we use it to connection mining of a functional kind. Moreover, the fuzzy membership values that have been found are specified linguistically, which means that fuzzy transforms make up their antecedent, and only evaluative linguistic terms characterize their consequent.
INSTRUCTIONAL SUPERVISION AND TEACHER COMPETENCE ENHANCEMENT IN SECONDARY SCHOOLS IN GREATER ARUA, UGANDA
Authors: Omara Polycarp , Naluwemba Frances , Ssetumba John Bosco
Published: September 2024

The development of teacher competence has been essential throughout history because the quality of every education system depends on the quality of its teachers. This study investigated the relationship between instructional supervision and teacher competence enhancement in secondary schools in Greater Arua, Uganda. Specific objectives were to examine the relationship between directive, collaborative and non-directive supervision and teacher competence enhancement in secondary schools in Greater Arua. The study hypothesised that there was no statistically significant positive relationship between directive, collaborative and non-directive supervision and teacher competence enhancement in secondary schools in Greater Arua, Uganda. The Positivist paradigm and a correlational design were adopted. The population comprised secondary school teachers (n=241) of selected secondary schools in Arua City and Arua District, Uganda. The data collection method was a survey. Study hypotheses were tested using the Pearson Correlation technique. The results revealed a positive relationship between directive supervision (r = 0.144** sig = 0.026), collaborative supervision (r = 0.145*, sig = 0.024) and non-directive supervision (r = 0.161* sig = 0.012, and teacher competence enhancement. The study concluded that all three dimensions of developmental supervision (directive, collaborative and non-directive) have a positive relationship with teacher competence enhancement. As a recommendation, school-based supervisors should apply a supervisory approach according to the competence level of a teacher. Ministry of Education and Sports should organise regular workshops and seminars for school-based supervisors on the principles of instructional supervision.
Factors Affecting Job Satisfaction Among Medical Postgraduate Trainees In A Tertiary Hospital, Imphal, Manipur : A Mixed Method Study
Authors: A Sangma Annastasia , Singh Akoijam Brogen , Pangambam Amrita , Singh Khangembam Sonarjit , R.L Pearson , Dhali Sneha
Published: September 2024

Background: Doctors’ dissatisfaction with their jobs can have significant public health implications as it may adversely affect the clinical management of patients and it may affect their health as well. Objectives: To assess job satisfaction and explore the perceived barriers and facilitators of job satisfaction among postgraduate trainees in a tertiary hospital, Imphal. Materials and Methods: A mixed-method study was conducted among postgraduate trainees. For the quantitative component, all the postgraduate trainees (430) enrolled in a tertiary hospital were included. For the qualitative part, participants were approached for in-depth interviews using purposive sampling till the saturation point was reached. Data was summarised in mean, standard deviation, and percentage. Chi-Square test and ANOVA, followed by Bonferroni for comparison were applied. Thematic analysis was done for qualitative data. Results: Overall, 89.1% of the participants were not satisfied with their jobs. Out of 405 respondents, 96 persons disagreed, and 42 persons strongly disagreed on being satisfied with their working hours. Participants were most satisfied in domains of teamwork, leadership, empowerment and participation. Among postgraduate trainees of different departments, PMR was the most satisfied and Obstetrics and Gynaecology was the least satisfied. Conclusion:  Most participants experienced burnout due to increased working hours and lack of work- life balance. They also expressed the need for rewards and recognition.
Pengaruh Faktor Politik Terhadap Discretionary Accruals Pada Pemerintah Daerah di Indonesia
Authors: Dewi Hilda Ratna , Gamayuni Rindu Rika
Published: September 2024

Penelitian ini bertujuan untuk memperoleh bukti empiris mengenai praktik discretionary accruals pada pemerintah daerah di Indonesia serta pengaruh faktor politik terhadap praktik tersebut. Analisis dilakukan menggunakan model random effects (REM) dengan perangkat lunak Eviews 10, dan discretionary accruals diestimasi sebagai proksi manajemen laba melalui Modified Jones Model. Hasil penelitian menunjukkan bahwa kepala daerah petahana memiliki pengaruh positif yang signifikan terhadap discretionary accruals, sedangkan tahun Pilkada tidak memiliki pengaruh. Dengan demikian, discretionary accruals cenderung lebih tinggi pada daerah yang dipimpin oleh kepala daerah petahana, sementara tahun Pilkada tidak memengaruhi perubahan discretionary accruals.
Service Quality and Customer Patronage: A Moderating Role of Staff Remuneration
Authors: Onyeonoro C.O. , Ohai P.N. , Aniemeke C.N. , Okoloagu C.U.
Published: September 2024

The study focused on service quality and customer patronage: a moderating role of staff remuneration. To achieve the objective of the study, survey research design was adopted. The researcher adopted primary data in getting the required information through the use of structured questionnaire. The population for this study is made up of all the customers of the selected hotels in Umahia, Abia state. Since the actual population of customers cannot be ascertained, the study will adopt infinite sampling. Therefore, sample size of the study is 196 after adopting infinite formula. The data generated from questionnaire administration were analyzed using frequencies, percentages and mean deviation while the hypotheses were tested using multiple regression analysis. The findings revealed that service reliability, service tangibility, service assurance, service responsiveness and service empathy have significant influence on customer patronage. The findings also revealed that staff remuneration has a moderating influence on the relationship between service quality and customer patronage in hotels. Based on the findings, the study recommends that employees of the hotels should give proper concentration to customers and should be willing to attend to them at every given time in order to gain their trust. That will guarantee repeat patronage. Also, hotel owners and managers should ensure that employee remunerations are provided as at when due. This would motivate employee to deliver quality service which will in turn affect customer patronage positively.
Experiencias Pedagógicas en Educación Infantil: ¿Qué enseñar a infantes con Dislalia?
Authors: Reina Mera Estefany Alejandra , Reina Mera Karen Daniela
Published: September 2024

El artículo aborda la cuestión central de cómo planificar y llevar a cabo una intervención educativa eficaz para niños en educación infantil que presentan Dislalia. Se presentan experiencias pedagógicas que combinan enfoques logopédicos y estrategias educativas orientadas a mejorar la articulación y la pronunciación de los sonidos afectados. El estudio resalta la importancia de una intervención temprana, ya que la plasticidad cerebral durante la etapa infantil facilita el éxito de las terapias fonéticas y fonológicas. Se analizan métodos que incluyen juegos lingüísticos, actividades lúdicas, ejercicios de pronunciación y conciencia fonológica. Las autoras también destacan el uso de material visual y auditivo para reforzar el aprendizaje de los fonemas problemáticos, como cartas fonéticas, canciones rítmicas y repeticiones guiadas. El trabajo subraya la colaboración estrecha entre maestros, logopedas y padres para garantizar una intervención coherente en todos los contextos en los que el niño participa. Además, se enfatiza la importancia de adaptar las estrategias a las necesidades individuales de cada niño, asegurando que las actividades sean tanto motivadoras como desafiantes para mantener el interés y la participación activa del infante. Finalmente, el artículo concluye que el éxito de la intervención pedagógica no solo depende de los ejercicios de corrección de la pronunciación, sino también de la inclusión de actividades que refuercen el desarrollo emocional y social, ayudando al niño a mejorar su autoestima y confianza al hablar.