bluuebunny/crossref_metadata_2025 huggingface dataset:
Conservation of Beirut’s Urban Heritage Values Through the Historic Urban Landscape Approach
Authors: Y. El-Bastawissi Ibtihal , Raslan Rokia , Mohsen Hiba , Zeayter Hoda
Published: January 2022

Cities are complex urban systems with dynamic transformations in their socio-economic and environmental dimensions. Several studies have shed light on the fragility of the urban heritage and the strategies of its conservation. The historic urban landscape (HUL) approach is a new framework adopted by UNESCO to deal with urban heritage. This article aims to apply the HUL approach to the rehabilitation and management of Beirut historic neighbourhoods impacted by the massive Beirut port explosion, focusing on Armenia Street in the Mar Mikhael neighbourhood as a case study. The application of the HUL framework allows for the re-evaluation of heritage not as an individual physical form but as an urban fabric interconnected to the city, inclusive of its cultural, social, architectural, and urban layers. The article investigates the application of the four tools identified within HUL recommendations—(1) regulatory systems, (2) community engagement, (3) planning, and (4) financial tools—by proposing implementation strategies in the assessment of urban heritage to mitigate major risks. The result reveals that cooperative efforts among private and public stakeholders can play a vital role in the development of Beirut heritage, acting as catalysts for urban heritage conservation. Strategies for establishing a new legislative framework that is focused on protecting Lebanese cultural heritage and ensuring sustainable adaptation planning are highlighted.
Fortalecimiento de la Salud Mental en el Trabajo de un grupo de administrativos adscritos a una Universidad pública de Colombia
Authors: Izquierdo-Santacruz Daniela Alejandra , Molina-Orbes Naiveth Carolina , Matabanchoy-Salazar Johana Madelyn , Zambrano-Guerrero Christian Alexander
Published: January 2022

Introducción: El estudio surge a partir del reconocimiento de las necesidades en torno a la Salud Mental en el Trabajo-SMT de un grupo de administrativos adscritos a una universidad pública de Colombia y desde la implementación de la modalidad de trabajo en casa derivada de la situación epidemiológica COVID-19. El objetivo es contribuir a fortalecer la salud mental en el trabajo a través de un programa fundamentado en el Modelo de Creencias en Salud-MCS. Metodología: Dicho programa se desarrolló mediante plataformas digitales, en el que se abordaron temáticas relacionadas con el manejo del estrés y la gestión del tiempo, siguiendo una metodología cualitativa, con enfoque de Investigación Acción-IA. Resultados y Discusión: Se obtiene la identificación de situaciones y/o estímulos percibidos como barreras para la realización de conductas salutogénicas y desde un enfoque preventivo, la estrategia centrada en educación para la salud aportó de forma significativa sobre el autocuidado en el desarrollo del trabajo en casa. Conclusiones: La implementación de este tipo de programas, que involucran a la comunidad durante el proceso, contribuyen sustancialmente al fortalecimiento de la salud mental en el trabajo desde necesidades contextualizadas, especialmente durante la contingencia sanitaria por COVID-19.
Tecnologías de la información y la comunicación: Percepción estudiantil del aprendizaje en tiempos de Covid 19
Authors: Castro-Campos Pedro Alfonso , Forero-Hernández Derly Janeth
Published: January 2022

Introducción: Los efectos causados por el COVID-19 en el ámbito educativo han tenido gran repercusión, se evidencia la capacidad de resignificación de metodologías en la búsqueda de estrategias para generar adaptaciones mediante la implementación de las TIC, con el propósito de caracterizar las percepciones de los estudiantes en el proceso de aprendizaje, frente al uso de las TIC. Metodología: Se realizó un trabajo desde el enfoque cuantitativo, con alcance descriptivo, a través de la aplicación de un cuestionario y con base a una muestra de 123 estudiantes. Resultados y discusión: Se da evidencia que más del 50% se encuentran satisfechos con la educación remota mediada por las TIC y un alto porcentaje considera tener buen dominio. Conclusiones: Esto proyecta un balance de la importancia del conocimiento y apropiación del uso de las TIC como medio para el aprendizaje y herramienta para lograr una formación holística desde la comunicación e interacción y la oportunidad de transformar el currículo actual.
Educación para niños no acompañados en los Estados Unidos: La perspectiva de los proveedores de servicios sobre los desafíos y las estrategias de apoyo
Authors: Evans Kerri
Published: January 2022

Introduction: Newcomer students seek routine and safety in schools, but often experience a “hard landing” when they begin school in the United States. Objective: While there is substantial literature on the academic and language achievement of emergent bilingual students, there is less specifically on unaccompanied immigrant students, and even less on their social and emotional well-being. Methodology: This study uses a human rights framework to analyze qualitative data from service providers (n = 79) for unaccompanied children. Results: Challenges to meeting the needs of this population include the limited capacity of schools and school districts, students’ language ability and preparedness for school, cultural differences, and individual health and mental health considerations. Supports to help immigrant students include academic and language assistance, cooperation among service providers, and emotional and behavioral programs. Conclusions: Recommendations include building community partnerships, creating more welcoming policies, school-assessments of programming compared to needs of newcomer students, and more research.
Benign cyst or malignancy? A six-year-old with primitive small round cell sarcoma of the right buttock: a case report
Authors: Amit Michelle L. , Barr Lori , Smith Erlyn
Published: January 2022

A six-year-old male presents with mass on his right buttock. After surgical resection, he was found to have a primitive small round cell sarcoma, high grade with CIC-DUX4 fusion gene. Treatment started with compressed regimen of VDC/IE (compressed Ewing protocol). There was initial improvement in visual appearance of the buttock/wound site but recurrence of the tumor occurred despite extensive surgical resection along with metastases to the lungs and bone which progressed and eventually led to death. This case adds to the collective knowledge regarding the CIC-DUX4 type of pediatric neoplasms and provides insight for future chemotherapy protocols.
Rehabilitation of partial edentulous patient with tooth supported over denture retained with metal coping-A case report
Authors: Wakure Poonam , Alam Maqbul , Rathee Manu , Malik Sanju
Published: January 2022

Overdenture treatment is a removable dental prosthesis that covers or rest on one or more remaining natural teeth, roots of natural teeth, or dental implants. The conventional tooth-retained overdenture is a simple and cost-effective treatment than the implant overdenture. This treatment is not a new concept and practitioners have successfully employed existing tooth structures to assist with complete denture treatment for more than a century. Furthermore, the use of copings on the remaining teeth enhances the retention of the denture. This clinical report describes a method of fabricating a tooth supported overdenture retained with custom made metal coping.
Serum ferritin: A hidden gem for diagnosing plummer vinson syndrome
Authors: Karthikeyan P , Rasmika K
Published: January 2022

Plummer-Vinson syndrome (PVS) is a triad of dysphagia, iron deficiency anemia and upper esophageal web. Early diagnosis with adequate treatment is necessary to prevent its malignant transformation.

To represent different clinical pictures of PVS and to evaluate the treatment outcome and determine its prevalence.

This is a descriptive study with study population of 267 patients with dysphagia and 40 had PVS. Post cricoid webs were dilated and post-operative iron correction was done. Patients are on regular follow up.

Analysis showed highest incidence in females with dysphagia being the main presenting complaint in all the patients. All had iron deficiency and 90% of patients had post cricoid web.

PVS is a precancerous condition. Serum ferritin should be the preferred parameter for diagnosing iron deficiency anemia. Regular follow up is warranted to prevent malignant progression.
Speech and swallowing difficulties and rehabilitation in osmotic demyelination syndrome: A single case report
Authors: Monish V , Sreedevi N
Published: January 2022

: Aim of the work was to highlight the speech and swallowing difficulties that are associated with osmotic demyelination syndrome and also the importance of speech and language therapy in patients with osmotic demyelination syndrome.

In this case report, a 68 years old female who developed osmotic demyelination syndrome as a result of hyponatremia correction has been described. The patient developed motor, speech and swallowing difficulties after 10 day of hyponatremia correction. For assessing speech and language skills, Bedside Screening Test for Persons with Aphasia was used. Gugging Swallowing Screen was used for assessing the swallowing skills.

: The assessment results indicated that the patient’s auditory comprehension skills were preserved and other verbal skills were affected as the patient had mutism. Also the patient had slight dysphagia with lower risk of aspiration. With speech-language intervention, improvement was observed in swallowing and verbal communication skills.

ODS is a rare clinical condition. In order to have a better perspective about speech, language and swallowing skills in individuals with ODS, replication of such studies are essential.
CANDID on COVID: Current & Continuing A to Z Cycle
Authors: Basavannaiah Sphoorthi
Published: January 2022

Coronavirus disease 2019 (COVID-19) is a contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The first known case was identified in Wuhan, China, in December 2019. The disease since then spread worldwide leading to an constant ongoing pandemic. With the changing global scenario, unpredicatable life, destructive scenes everywhere this deadly micro virus has easily managed to bring the world to its knees with its changing variant, multiplying behaviour and mutating ability. Here, I have tried to get a glimpse of this “COVID” sights, sections & sequelae at a glance that has been face by the world since December 2019 till date.
PERAN PEMBINA PENGEMBANGAN DIRI MELALUI ROHANI ISLAM (ROHIS) DALAM MENINGKATKAN SIKAP KEBERAGAMAAN SISWA DI SMK SALATIGA
Authors: Rodhiyatun Mushbihah
Published: January 2022

Pengembangan diri dalam bentuk ekstrakurikuler mengandung arti didalamnya terjadi verifikasi program berbasis bakat dan minat yang memerlukan pelayanan pembinaan khusus sesuai dengan keahliannya. Penelitian ini bertujuan untuk mengetahui upaya yang dilakukan pembina pengembangan diri melalui Rohani Islam (ROHIS) dalam meningkatkan sikap keberagamaan siswa di SMK Salatiga yang diwakili oleh SMK Negeri 01, SMK Negeri 02, SMK Pelita dan SMK Islam Sudirman Salatiga. Jenis penelitian ini adalah kualitatif dengan pendekatan sosiologis. Sumber data yang diperoleh yaitu sumber data primer dan sekunder. Pengumpulan data melalui teknik observasi, interview, dan dokumentasi. Teknik analisis datanya dengan cara mereduksi data, display data dan mengambil kesimpulan. Permasalahan yang dibahas  meliputi berbagai bentuk pengembangan diri melalui ROHIS, dinamika aktivitas dan peran pembina serta hubungan sosiologis pengaruh pembina pengembangan diri melalui ROHIS terhadap peningkatan sikap keberagamaan siswa. Hasil penelitian menunjukkan bahwa pembina pengembangan diri melalui ROHIS mempunyai peranan yang sangat besar dalam peningkatan sikap keberagamaan siswa di SMK Salatiga yaitu sebagai motivator, creator dan inovator, integrator, serta sublimator.
Manifestaciones neurológicas por COVID-19. Reporte de casos en Hospital Militar Central Bogotá, Colombia, y revisión de la literatura
Authors: Lancheros Pineda Lina María , Yasno Arias Diana Alejandra , Zea  Rojas Diana Isabel , Torres Ballesteros Viviana , Bernal Pacheco Oscar
Published: January 2022

Acorde a las fuentes epidemiológicas de la Organización Mundial de la Salud, en la última década, entre las principales causas de mortalidad más del 55 % resultaban de enfermedades no transmisibles, predominando la isquemia cardiaca y el accidente cerebrovascular como causales. En el 2019, con la aparición del nuevo coronavirus, COVID-19, como etiología de la pandemia que ha impactado tanto en salud como económica y socialmente al mundo, las cifras de la curva de las causas usuales de mortalidad han cambiado no solo a causa del efecto directo de la enfermedad en los múltiples órganos, sino también por los efectos indirectos en relación con falta de acceso a atención médica en enfermedades crónicas. Dado que es una enfermedad transmisible, el COVID-19 produce alteraciones, principalmente respiratorias y vasculares, sin embargo, el mayor conocimiento de los aspectos fisiopatológicos de la enfermedad ha revelado el compromiso de múltiples sistemas, destacando el sistema nervioso central como un objetivo del virus que impacta en las secuelas y los desenlaces de los pacientes, de modo que se documentan manifestaciones neurológicas hasta en un 55 %. El objetivo de esta revisión es caracterizar una serie de casos de pacientes en el Hospital Militar Central, mediante la descripción de aspectos fisiopatológicos y clínicos del compromiso neurológico
Numeryczne symulacje procesu magazynowania wodoru w częściowo wyeksploatowanym złożu gazowym
Authors:   Instytut Nafty i Gazu – Państwowy Instytut Badawczy, Szott Wiesław , Miłek Krzysztof ,   Instytut Nafty i Gazu – Państwowy Instytut Badawczy
Published: January 2022

"W pracy przedstawiono charakterystyki potencjalnych struktur możliwych do wykorzystania w celu magazynowania wodoru. Sformułowano kryteria wyboru optymalnej struktury, takie jak: pojemność dostępna dla wodoru, zakres historycznych ciśnień złożowych, ciśnienie szczelinowania, własności transportowe skały, aktywność wody podścielającej, rodzaj płynu złożowego, temperatura złożowa. Stosując te kryteria, wybrano strukturę złoża gazu ziemnego funkcjonującą obecnie jako PMG (podziemny magazyn gazu). Dla znalezienia charakterystyk wybranej struktury jako PMW (podziemnego magazynu wodoru) skonstruowano kompozycyjny model złożowy poprzez konwersję istniejącego modelu typu black oil. W tym celu model złoża uzupełniono o wieloskładnikowy model płynu złożowego opisany równaniem stanu Soave’a–Redlicha–Kwonga oraz o kompozycyjne hydrauliczne modele odwiertów. Kompletny model złoża efektywnie skalibrowano, wykorzystując wieloletnie historyczne dane eksploatacyjne obejmujące wydajności wydobycia ze złoża, zatłaczania i odbioru gazu w ramach PMG oraz ciśnienie zmierzone na spodzie odwiertów eksploatacyjnych. Zweryfikowany model wykorzystano do wielokrotnych symulacji procesu magazynowania wodoru, stosując realistyczne ograniczenia dla zatłaczania i odbioru gazu, tj. czas zatłaczania i odbioru, limity na sumaryczną ilość zatłaczanego wodoru oraz odbieranego gazu, minimalną czystość odbieranego wodoru. Rozpatrzono warianty różniące się szczegółami konwersji PMG na PMW oraz zakładanym maksymalnym stopniem zanieczyszczenia odbieranego wodoru. Podstawowe własności geologiczne wynikały z oryginalnych właściwości struktury i nie podlegały modyfikacjom, natomiast nieznany, ale istotny parametr dyspersji, decydujący o mieszaniu się gazu zatłaczanego z gazem rodzimym, był przedmiotem analizy wariantowej. Wyniki ilościowe prognoz pracy PMW uzupełniono szczegółową analizą rozkładów nasycenia wodorem na różnych etapach i w różnych cyklach pracy magazynu. W pracy badano wpływ zjawiska dyspersji na wyniki pracy magazynu poprzez implementację zjawiska dyspersji numerycznej, weryfikację poprawności korelacji dyspersji z prędkością migracji oraz identyfikację wielkości dyspersji dla różnych wariantów modelu złoża."
Godność człowieka na tzw. „rynku pracy”
Authors: Sztumski Janusz
Published: January 2022

Human dignity has been considered by philosophers in the human being itself, as a man is a thinking entity holding the free will. A men has right to dignity regardless of his or her sex, age, race, social position or merit. Owing to its dignity, a man should not have been considered substantively but subjectively. So a man should not be any measure but only an aim for another man. Whether, and to what extent, one can talk about human dignity, when a man agrees to be present in the labour market as so-called workforce, i.e. as an instrument needed in the implementation of any of the purposes of the other? Can we talk about dignity of a human being, who is employed in the labour market, on which he competes with other similar beings, sometimes demeaning himself to meet very existential needs? Here are the problems that are the subject of this article.
Etos dziennikarza – mit czy rzeczywistość?
Authors: Bocian Natalia
Published: January 2022

This paper is an attempt to confront the opinion of Polish journalists, on the state of ethical principles in their operating environment to a set of rules in the Charter of Media Ethics. It tries to explain how, in the opinion of journalists, standards exist on paper are reflected in the daily journalistic work. The paper will be presented codes operating in the Polish media content analysis and the results of five leading weeklies "Gość niedzielny", "Polityka, Newsweek", "Wprost", "Przekrój", "Przegląd" on the cross section of the period from January to March 2010.
Histomorphological Changes in the Mammary Gland of Local Indian Goat during Lactation Cycle
Authors: Vaish Rakhi , Taluja J.S. , Gupta Nidhi , Pandey Yogita , Jain Payal , Tekam Shashi
Published: January 2022

Background: In developing countries goat rearing is the sustainable source of income for marginal farmers. The goat milk contains lower fat per cent (3.5%) as compared to cow (4.1%) and buffalo milk (7.4%), with smaller and homogenous fat globules. It is suitable for the persons with poor digestibility of cow milk and infants having mother milk intolerance. To improve the milk production it is important to understand the mammary gland pattern during the different phases of lactation. The present study aimed at analyzing these changes by histological and histochemical observations. The mammary gland is composed of parenchyma containing acini and stroma including the ductual system. These components change during the lactation cycle. Methods: The present study was conducted on 24 goats, eighteen in lactating stage where as six from nonlactating stage. The mammary glands were collected from local abattoir with known history of stage of lactation and divided into three groups as early lactation (2-4 weeks), mid lactation (5-6 weeks) and late lactation ( greater than 6 weeks). The histological and histochemical studies were performed during the different stages of lactation and in non lactating stage to observe the morphological and morphometrical changes along with the presence and absence of different components. Result: The lobules of the mammary gland were polygonal, triangular, oval or elongated in shape during early lactation stage. Approximately all the alveoli observed in early lactation were filled with variable quantity of eosinophilic substance and appeared foamy, due to presence of variable size of fat vacuoles. In mid lactation the lobules became highly irregular. The long and short diameter of lobules was 1041.69 µm and 563.93 µm, respectively. The intralobular stroma was inconspicuous hence alveolar wall appeared to touch each other. In late lactation lobules became shorter in size. The large alveoli showed folded and collapsed appearance. In nonlactating stage well defined alveoli, clusters of desquamated cells were seen and degenerated alveoli were also observed. These histomorphological changes in the secretory unit of the mammary gland reflect the lactation yield and milk composition during different stages of lactation.
A Rapid and Efficient Plant Regeneration Protocol using Leaves and Stems with Buds of Euphorbia pulcherrima Willd. ex Klotzsch (Euphorbiaceae)
Authors: Qiu L.W. , Huang G.Y. , Zhang G.Y. , Li H. , Hu M.X. , Wu J.H. , Chen H.Y.
Published: January 2022

Background: Euphorbia pulcherrima is highly ornamental value of poinsettia flower, which posses colorful bracts and low temperature resistant leave. Its embryos or adventitious buds were cultivated mainly from stems, petioles and tender buds. The cultivation of seedlings is studied firstly for improving the quality of Poinsettia. Methods: A rapid and reproducible regeneration system of leaves and stems with buds has been established. There is a comparative analysis of the results of tissue culture of different varieties of Poinsettia. Result: The best medium component of hormones about leaf callus of poinsettia inducing cluster buds formation comprise 6-BA 1.0 mg/L, KT 0.4 mg/L, NAA 0.1 mg/L and 2,4-D 0.05 mg/L. Its medium component inducing cluster buds proliferation include 6-BA 1.2 mg/L and NAA 0.05 mg/L. The medium component about stem with bud inducing cluster buds to germinate comprise 6-BA 1.5 mg/L and NAA 0.1 mg/L. Its medium component inducing cluster buds proliferation include 6-BA 1.0 mg/L and NAA 0.05 mg/L. The different hormones and different addition level of Ac have effect on the length of the root and quantity of the first level root and the second level root.
Nöral Yaşlanma ile İlişkili Süreçlerin Nöroplastisite Üzerine Etkisi
Authors: ALBAYRAK İrem Gülfem , MUTLU Elif
Published: January 2022

Yaşlanma, nöronal plastisite mekanizmalarını doğrudan etkileyen ve hücresel süreçlerdeki değişikliklerle açıklanabilen bilişsel işlevlerdeki gerileme ile ilişkili bir süreçtir. Yaşlanma süreci beyin boyutunda küçülmeye, beyin vasküler sisteminde ve bilişsel işlevlerde bozukluklara sebep olmaktadır. Beyinde gerçekleşen küçülme ile birlikte moleküler seviyeden doku seviyesine kadar her düzeyde işlevsel değişiklikler meydana gelmektedir. Nöral plastisite mekanizmaları bilişsel fonksiyonları düzenlemekte; öğrenme ve hafıza gibi fonksiyonların devamlılığı ve işlevselliği üzerinde önemli bir rol oynamaktadır. İlgili süreçlerde yaşın ilerlemesine bağlı olarak önemli ölçüde azalma gözlenmektedir. Bu derleme çalışması ile doğal yaşlanma sürecinin nöral plastisite üzerine olan etkisi hipokampus, medial temporal lob ve prefrontal korteks yapıları üzerinden; davranışsal, morfolojik, hücresel ve moleküler yönleri ile tartışılarak; yaşlanmanın nöral plastisite üzerindeki etkisi ve yaşlanma ile ilişkili nöropatolojiler incelenecektir.
Effects of Enzyme Replacement Therapy on Quality of Life, Functional Independence and Aerobic Capacity in Children with Mucopolysaccharidosis
Authors: SÖKÜCÜ Fatmanur , YİĞİT Sedat , PEKTAŞ Emine , MUTLU ALBAYRAK Hatice , PERK YÜCEL Peren , USGU Serkan , YAKUT Yavuz
Published: January 2022

: The mucopolysaccharidosis (MPS) can lead to poor endurance and mobility, often associated with pain, restricted range of motion (ROM), low energy levels and fatigue, negatively affecting quality of life and activities of daily living. This study aimed to examine the impact of enzyme replacement therapy (ERT) on aerobic capacity, functional independence and quality of life in children with MPS and to determine the anxiety and depression levels of their caregivers. Study Design established in Cross sectional study. Twelve children aged 3 to 11 years were included in the study. The subjects were divided into two groups according to the use of ERT. Quality of life and functional independence were assessed using the Pediatric Quality of Life Inventory (PedsQL) and Functional Independence Measure for Children (WeeFIM). The 6-minute walk test (6MWT) and timed up and go test (TUG) were used to evaluate aerobic capacity. Anxiety and depression levels of parents were assessed using the Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI), respectively. A total of 12 MPS patients 7 boys (58.3%) and 5 girls (41.7%) with a mean age of 5.58±2.67 years were included in the study.1 patient had MPS type I, 2 patients had MPS type III, 5 patients had MPS type IV, and 4 patients had MPS type VI. Six patients were receiving ERT. The children had a mean 6MWT score of 330.83±114.29, a mean TUG score of 14.24±5.71 sec, a mean PedsQL score of 46.83±14.03 and a mean WeeFIM score of 70.83±26.85. Their caregivers had a mean BAI score of 19.25±10.95 and a mean BDI score of 19.41±6.81. A significant difference was found between the children receiving ERT and those not receiving in the WeeFIM scores (P0.05). ERT did not change aerobic capacity and quality of children with MPS but increased their level of functional independence. Multisystem involvement in MPS children may affect anxiety and depression levels of their caregivers but ERT does not seem to have any effect on this psychosocial aspect.
Organizational and pedagogical conditions for formation of metasubject competencies in future teachers of the system of additional education
Authors:   Yaroslavl state pedagogical university named after К. D. Ushinsky, Mukhamedyarova Natalya A.
Published: January 2022

The article is devoted to the problem of formation of metasubject competences among teachers of the system of additional education for children (DOD). The relevance of this topic is due to the rapid development of the field of preschool education as an integral part of the system of continuous education, where the key role is played by the teaching staff. The results of a pilot study of the level of formation of metasubject competencies among pedagogical workers of the system of additional education for children (198 people) revealed the problem of mastering the most important of them such as information, research, communicative, organizational and managerial and competencies of self-organization and self-development. These and many other metasubject competencies need to be formed in the process of teaching future teachers of the system of additional education for children, as well as in the process of their further professional development. In this work, the author reveals the essence and structure of the metasubject competencies of a teacher of educational institutions, which were identified as a result of a theoretical and practical analysis of the features of the modern system of educational institutions, requirements for the «teacher of educational institutions» profession and the specifics of his pedagogical activity. The metasubject competences included information, research, communication, organizational and management, and the competence of self-organization and self-development. The article indicates that the effectiveness of the process of forming metasubject competencies is determined by a complex of organizational and pedagogical conditions: intradisciplinary, interdisciplinary and transdisciplinary integration of professional development and training of teachers. The description of these conditions, their main content is presented. The author describes the main results of the study, stating the problems and deficiencies in the formation of metasubject competencies among future teachers. Among all the studied competencies, only the informational one turned out to be at an advanced level, research, communication, organizational and managerial and the competence of self-organization and self-development are at the initial level. After the experimental work, having realized the organizational and pedagogical conditions, a positive dynamics in the formation of competencies was shown, the respondents reached a high level. The conclusions stated in the article can be useful for managers and teaching staff of institutions of higher and nonuniversity professional education, for general educational organizations, organizations of additional education for children, as well as for institutions of additional professional education (advanced training).
Cultural potential of the clown art in the formation of pedagogical competences in the mass media era
Authors:   Institute of art education and culturology of Russian Academy of Sciences, Semenova Elena A.
Published: January 2022

The article is devoted to the consideration of the art of clowning as a tool for diagnosing pedagogical competencies that are constantly transforming under the influence of the mass-media cultural paradigm.It is suggested that the image of a clown in modern culture translates a conglomerate of behavioral patterns historically entrenched in the mass consciousness, which have a high cultural and pedagogical potential. A hypothesis is proposed, according to which the attitude to the figure of a clown, as to a pattern of cultural and creative behavior, can be a marker of the teacher's professional competence. The teacher's ability to distinguish a fictional character (a set of situations in which the hero-clown finds himself; episodes in which he appears; his individual characteristics) from a real person; serious activity from play and comic creativity; find it possible to compare their behavior in some cases with the clown one; the manifestation of humorous reflection and laughter creativity are considered as such urgent modern pedagogical competencies as laughter reflection, laughter self-presentation and laughter creativity. The study is based on the provisions of the concept of resilience by S. Vanishtendael; researches devoted to culturological, art history analysis of the figure of a clown. The intermediate results of the pilot survey confirm that the figure of the clown is perceived by teachers as ambivalent, either as a creative person, or as an artistic image of art and media reality, or as their symbiosis. Humorous self-reflection and laughter self-presentation of the teacher can be considered as a predictor and correction of the further trajectory of his professional activity. The peculiarities of the perception of the figure of a clown as a pattern of cultural and creative behavior can be used as a diagnostic tool for determining the level of formation of the teacher's actual pedagogical competencies in the era of mass media.
Comparative analysis of the concepts of students integration into the university environment by means of education
Authors:   Yaroslavl state pedagogical university named after К. D. Ushinsky, Enzeldt Nikita V.
Published: January 2022

The article emphasizes the idea that any modern university aimed at openness and interaction with its main clients – students-needs mechanisms for integrating past applicants into the university environment. The author analyzes theconcepts of «educational environment» and «university environment», characterizes the main features of the latter, which allow us to talk about the successful adaptation of students to the educational process. Answering this question, the author discusses what the university environment of a pedagogical university should be like, so that students find support for their self-determination as a future teacher and are not disappointed in receiving pedagogical education after starting their studies. Based on comparative research methods, the author makes an attempt to compare different professions of a teacher – what a teacher should be, what qualities he should acquire during training in order to become a «real» teacher. The article also develops the idea of the need to use the competence-based approach in training, its advantages and opportunities. The key role, according to the author of the article, is assigned in this direction to universal competencies – the abilities necessary for a graduate of any higher educational institution in accordance with the Federal State Educational Standard 3++. It is the level of formation of universal competencies that can indicate the quality of training of a specialist as a whole. In conclusion, the article concludes that it is the university environment that largely shapes the future graduate, offering him opportunities for self-realization, creativity and professional development. The author postulates that in the process of the environment modernization, the important fact is the ability of the student to influence the environment in which he is studying, he only needs to be given to understand this and allow him to act. The study was carried out as part of the state task of the Ministry of Education of the Russian Federation № 073- 00077-21-02 to carry out scientific research on the topic «Scientific rationale and development of methodology for ensuring the continuity of Federal Educational Standard in general, secondary professional and higher pedagogical education in order to make a single educational space for the training of teaching staff» (Registry entry No.730000Ф. 99.1.БВ09АА00006)
Psychological Characteristics of Substitute Families' Living Strategies
Authors:   Smolensk State University, Belugina Mariya A.
Published: January 2022

This article presents a comparative analysis of the psychological personality characteristics of foster families and families without foster children. The article specifically focuses on foster family concept and consistently describes various forms of adopting children. While formulating the leading motives for adopting children and the main challenges of foster parents, the article also presents some methods of working with foster families in order to increase their willingness to adopt a child as well as facilitate mutual adaptation of parents and children. The concepts of life strategy, life satisfaction, and its fulfilment are also reviewed. The analysis in the article covers the structure of foster parents’ life strategies, including the vision of the future by the studied parental groups, the specifics of constructing a time perspective, a system of meaningful life orientations of the personality, and also establishes some psychological properties of the personality that determine the conscious life strategy construction. Special focus is placed on the differences in the development of the structural components of personality self-regulation, its reflection ability. The study uses the following psychodiagnostics techniques: questionnaire by V. Morosanova “The style of self-regulation of behavior-SSRB”, the test “Life satisfaction index A” (LSIA), adaptation by N. V. Panina, test «Life-meaning orientations» (methodology of LSS) D.А. Leontiev, estimation of five-year intervals (A. A. Kronik's method). The formulated conclusions allow to systemize the specifics of foster families in terms of their personal organization and can be used in consultative work with them.
Female political activity as a result of spreading feminism ideas and the modernization of russian provincial culture at the beginning of the XX century (based on the materials of Vologda newspapers)
Authors:   Herzen Russian State Pedagogical University, Sobakina Anna A.
Published: January 2022

The article considers the cultural problems of genesis and the spread of feminist sentiments in the Russian province of the early XX century in the context of women's participation in the political life of the Russian Empire. Theemancipation of women is one of the most revealing processes within which there is a struggle between conservative and modernist values of social consciousness, which determine the spiritual content of the both that era and modern times. The culmination period for the women's movement for equality was the revolutionary time of the late XIX — early XX centuries, when women in Russia managed to achieve impressive results in this direction. This was due to several reasons. Firstly, the socio-cultural modernization of the turn of the XIX-XX centuries invaded for a long time the ideas of people about the role and purpose of women, as well as about relations between the sexes, which seemed immutable and inviolable, that is, it affected the so-called «gender sphere», which gave a new impetus to the ideology and movement of feminism. Secondly, in Russia, where there was always a special interest of society in the «female» topic, the history of the development of this phenomenon had its own features, and in some respects the emancipation process was even ahead of the european one. Thirdly, the historical connection of russian feminism with the revolutionary liberation movement and the prevailing pre-revolutionary situation in the country played a large role in this, and therefore the socio-political aspect of female activity in Russia at the beginning of the twentieth century is of particular interest. At the same time, not only the events and processes themselves with the participation of women are important and significant, but also the perception and assessments of them by modern people, given in the article on the example of the analysis of Vologda newspaper publications of the early Modernism period. For the first time, articles from the newspapers «Vologodsky Listok», «Russky Sever» and «Severnaya Zemlya» were introduced into scientific circulation.
Readings from a book by Victoria Sweet: A novel medical ethics learning experience.
Authors: Muralidharan Jananee , Pinto Althea , Hopkins Pradeep , Bhugra Arjun , Kurpad Sunita Simon , Idiculla Jyothi
Published: January 2022

As part of the postgraduate ethics sensitisation programme at St. John’s Medical College, the faculty and students read excerpts from the book “God’s Hotel” by Dr. Victoria Sweet. The reading was followed by personal reflection by the speaker and the session concluded with a discussion among the audience. Summarised below are the passages from the book and the reflections from each speaker, with feedback from the audience. The stories explore various dimensions of the doctor-patient relationship, respecting the wishes of patients, care of the terminally ill, coping with colleagues, and dilemmas in patient management.
Displacement Formulations for Deformation and Vibration of Elastic Circular Torus
Authors: Sun Bohua
Published: January 2022

The formulation used by most of the studies on an elastic torus are either Reissner mixed formulation or Novozhilov's complex-form one, however, for vibration and some displacement boundary related problem of a torus, those formulations face a great challenge. It is highly demanded to have a displacement-type formulation for the torus. In this paper, I will carry on my previous work [ B.H. Sun, Closed-form solution of axisymmetric slender elastic toroidal shells. J. of Engineering Mechanics, 136 (2010) 1281-1288.], and with the help of my own maple code, I am able to simulate some typical problems and free vibration of the torus. The numerical results are verified by both finite element analysis and H. Reissner's formulation. My investigations show that both deformation and stress response of an elastic torus are sensitive to the radius ratio, and suggest that the analysis of a torus should be done by using the bending theory of a shell, and also reveal that the inner torus is stronger than outer torus due to the property of their Gaussian curvature. Regarding the free vibration of a torus, our analysis indicates that both initial in u and w direction must be included otherwise will cause big errors in eigenfrequency. One of the most intestine discovery is that the crowns of a torus are the turning point of the Gaussian curvature at the crown where the mechanics' response of inner and outer torus is almost separated.
Recovery of Food Wastes for Maggot Production as Animal Feed and Potential Tool to Solid Waste Management
Authors: Mkilima Timoth
Published: January 2022

Waste recovery is an important aspect towards human and environmental health protection. Unfortunately, proper food waste management is among the serious challenges in the field of solid waste management worldwide. Therefore, it is of great importance to conduct studies towards achieving efficient and cost-effective approaches for food waste management. This study investigated the potential of recovering food waste through maggots’ production as animal feed. The influence of fly attractant application on maggot production was also investigated. The study also investigated the potential of maggot production for waste recovery and reduction. Four different types of food waste (starch food leftovers, rotten bananas and peels, rotten pineapple and peels, and rotten oranges) were used in the investigation process. From the results, it was observed that the application of fly attractants had a significant effect on the production of maggots as determined by the weights after harvesting. Average weight of 94 g/kg of maggot was achieved from banana materials with an application of fly attractant during the 8th day of the cultivation; which is equivalent to a 32.4% increase from the same day when the material was cultured without applying fly attractant. Also, from the starch materials, about 77 g/kg of maggot weight was achieved; which is a 54.6% increase from the same day and the same material but without application of fly attractant. Moreover, the relative dry weight reduction in the trials varied from 52.5% to 82.4%.
A Pyroptosis-Related LncRNA signature in Prognosis and Immune Microenvironment infiltration Prediction of Ovarian Cancer
Authors: Liu Zhao YI , Chen Yong Chang , Wu Nayiyuan , Li He , Wang Jing
Published: January 2022

Background: LncRNA and pyroptosis play important roles in cancer development and tumor immune microenviroment. However, pyroptosis-related lncRNAs (PRLs) in ovarian cancer have not been identified and its impact on prognosis and immune response are not fully understood. Methods: Using pearson correlation analysis, PRLs were screened. Subsequently, we constructed a prognosis signature by using LASSO cox regression. In addition, the association between risk score and cancer immune environment was analyzed. Results: In TCGA-RNA-seq cohort (n=377), 32 prognostic PRLs were selected and a 7-gene signature were developed and had high accuracy in predicting the OS of ovarian cancer patients. Stratification analysis suggested that it might serve as an independent prognostic indicator. Except to clinical outcome, the signature was significantly associated with tumor immune microenvironment. Patients with high risk score exhibited lower infiltration abundance of MHC class Ⅰ cells, Type Ⅰ IFN response and immunotherapy response. In ovarian cancer, TYMSOS was highly expressed and its high expression was associated with worse OS. TYMSOS deletion in ovarian cancer cell lines inhibited the cell proliferation, invasion and migration, indicating that it might serve as a novel biomarker in ovarian cancer. Conclusions: The prognostic PRLs signature constructed in this work is available for prognostic prediction and immune microenvironment infiltration in ovarian cancer.
Spatial Distribution of Cyclograpsus cinereus Dana 1851 in Rocky Shores of Antofagasta (23º27’ S, Chile)
Authors: Rios-Escalante Patricio De los , Esse Carlos , Retamal Marco Antonio , Zuñiga Oscar , Fajardo Maritza
Published: January 2022

The decapod fauna in intertidal rocky shore in continental Chile has high species diversity mainly in northern and central Chile due high productivity of these coast due influence of cold Humboldt stream. One of the abundant species in these ecosystems is decapod Cyclograpsus cinereus Dana, 1851. The aim of the present study was determine the spatial distribution pattern of C. cinereus along rocky shore in Antofagasta bay, north of Chile between spring and summer 2018-2020. Data was obtained counting individuals from random quadrants in intertidal zones, to the obtained data was applied the variance mean ratio for determine if the specimens have random, aggregate or uniform distribution, that are associated to Poisson, negative binomial or positive binomial distributions respectively. Data obtained revealed the existence of associated distribution with respective negative binomial distribution pattern in 16 observations, and uniform distribution for 3 observations. The sites corresponds to rocky shores in urban zones, and in a protected zone, and the density does not have significant differences for both kind of sites. The observed data about aggregated pattern agree with observations for decapods for rocky shore in central and southern Chile, specifically in interpretative probabilistic models.
Design, Synthesis and Structure-activity Relationship Studies of Meridianin Derivatives as Novel JAK/STAT3 Signaling Inhibitors
Authors: Zhang JianQiang , Li Rui , Dong XueYang , He Na , Yin RuiJuan , Yang MengKe , Liu JieYu , Yu RiLei , Zhao ChenYang , Jiang Tao
Published: January 2022

Hyperactivation of Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) signaling is an attractive therapeutic target for tumor therapy. Herein, forty-eight novel meridianin derivatives were designed and synthesized, and their anti-tumor activity were evaluated in vitro both for activity optimization and structure-activity relationship (SAR) study. The results indicated that most derivatives exhibited significantly improved anti-tumor activity, especially for compound 6e. The compound 6e contains an isothiouronium linked by an alkyl chain consisting of 6 carbon atoms with IC50 ranging from 1.11 to 2.80 μM on various cancer cell lines. Consistently, 6e dose dependently induced the apoptosis of A549 and DU145 cells, in which STAT3 are constitutively active. Western blotting assays indicated that the phosphorylation levels of JAK1, JAK2 and STAT3 were inhibited by 6e at 5 μM without significant change in total STAT3 level. Moreover, 6e also suppressed the expressions of STAT3 downstream genes, including c-Myc, Cyclin D1 and Bcl-XL at 10 μM. An additional in vivo study revealed that 6e at the dose of 10 mg/kg could potently inhibit the DU145 xenograft tumor without obvious body-weight loss. These results clearly indicate that 6e could be a potential anti-tumor agent by targeting JAK/STAT3 signaling pathway.
Hydrocode Investigations of Terminal Astroballistics Problems During the Hypothetical Future Planetary Defense System’s Space Mission
Authors: Mroczkowski Maciej , Kachel Stanisław , Kozakiewicz Adam
Published: January 2022

The article is devoted to the preliminary concept of the Future Planetary Defense System (FPDS), emphasizing Astroballistics. This paper is intended to support international efforts to improve the planetary security of the Earth. The work covers three areas of knowledge: Astronautics, Astrodynamics, and Astroballistics. The most important part of the presented article is dynamic, contact combat modeling against small, deformable celestial bodies. For these purposes, the original, proprietary hydrocode of the Free Particle Method (HEFPM-G) with gravity was used. The main aim of combat is to redirect the Potentially Hazardous Objects (PHOs) to orbits safe for the Earth or destroy them. This concept's first task is to find, prepare and use dynamic three-dimensional models of celestial bodies' motion and spacecraft or human-crewed spaceships in the Solar System's relativistic frame. The second task is to prepare the FPDS' architecture and computer simulation space missions' initial concepts in the internal part of the solar system. The third and main task covers simulating, using hydrocodes, selected methods of fighting 100 m and 140 m diameter asteroids. The order of the article is as follows. The first part of the article presents an architecture and FPDS' modus operandi. Preliminary design and development of FPDS' space missions, including navigation, mission dynamics simulation, is prepared using an open-source space mission analysis and design tool. E.g., Asterank and Trajectory Browser or GMAT are presented in the second part. The third part of the article is devoted to computer hydrocodes (HEFPM-G) and the modeling and simulation of asteroid–asteroid collision, laser radiation effects on an asteroid, and FPDS spacecraft's warhead contact interaction on the small celestial body. The authors formulated the Main Planetary Defense Problem (MPDP) in this paper. The proposition of this problem solving has been realized by preparing its concepts, architecture, and modus operandi of the FPDS mission. Finally, a series of realistic simulations were made using hydrocode to deflect or destroy dangerous asteroids. The summary and conclusions can be found in the fourth part of the article.