bluuebunny/crossref_metadata_2025 huggingface dataset:
Georesources in Cultural Heritage: the Mg/Ca Ratio in Lime as a Marker of Variations in the Exploitation of Lime Stones in the Vercelli Area (Piemonte, Italy) over the Centuries
Authors: Mancini S. , Gambino F. , Dino G. A.
Published: June 2024

Archaeological investigations in the rural settlements of the Po Valley in the Piedmont region of Northern Italy, particularly in the Monferrato area, have revealed a wide range of structures dating from the Roman to the Early Medieval periods. This rural architecture is of great heritage value, as it provides insights into the historical development of Piedmont.

This paper focuses on the analysis of lime, one of the oldest and most important building materials, used as binder of bedding mortars of three archaeological rural buildings sites dating from the Early Roman imperial Period to the Late Antique phases of medieval fortified centers of Piedmont region.

A low-cost and efficient diagnostic geochemical-based method based on the characterization of two oxides present in the lime of mortars and in carbonate rocks of the area (MgO and CaO) is presented. Exploited limestone quarries exploited often have a fairly constant chemical composition and therefore a typical geological Mg/Ca ratio. The variation in this ratio is useful for the relative dating of building walls and for identifying of geological formations and quarries possibly used during the different architectural phases. This paper focuses on this second objective: the study of potential supply areas across the ages related to the ancient communication routes.
Determinants of unhealthy BMI among women of childbearing age in Bangladesh
Authors: Khudri Md Mohsan , Osmani Ahmad Reshad , Okunade Albert A.
Published: June 2024

This paper investigated the determinants of unhealthy BMI categories, namely underweight, overweight, and obesity, for urban and rural women of childbearing age in Bangladesh. Multilevel nested logistic models were estimated using data from multiple waves (2004–18) of the Demographic and Health Surveys of Bangladesh. After controlling for community and regional effects, the underweight status showed an inverse relationship with years of education for urban and rural women. Conversely, the fitted model estimates revealed a positive association between overweight risk and education for both urban and rural women populations. However, the association between obesity and education was significant for only urban women. Employment status appeared to be negatively associated with the risks of being overweight and obese in both population groups. Moreover, the women were found less likely to be underweight and more likely to be overweight and obese when their household socio-economic status improved. Study findings have the potential to inform a wide range of interventions, policies and programs that simultaneously address the adverse consequences of underweight, overweight, and/obese population health conditions in rural and urban Bangladesh.
DNA simulation benchmarks revealed with the accumulation of high-resolution structures
Authors: Olson Wilma K. , Young Robert T. , Czapla Luke
Published: June 2024

DNA carries more than the list of biochemical instructions that drive the basic functions of living systems. The sequence of base pairs includes a multitude of structural and energetic signals that determine the degree to which the long, threadlike molecule moves and how it responds to proteins and other molecules involved in its processing and packaging. The arrangements of successive base pairs in high-resolution protein-DNA crystal structures provide useful benchmarks for atomic-level simulations of double-helical DNA as well as information potentially useful in interpreting the properties of specific DNA sequences. The set of currently available structures has enough examples to characterize the conformational preferences of the DNA base-pair steps within the context of their immediate neighbors, i.e., in the context of tetramers, and reveals surprising effects of certain neighbors on local chain properties. The proteins in contact with DNA present various microenvironments that sense and/or induce the observed spatial forms. The cumulative buildup of amino-acid atoms in different protein-DNA complexes produces a binding cloud around the double helix with subtle sequence-dependent features. While the microenvironment presented by each protein to DNA is highly unique, the overall composition of amino-acid atoms within close range of DNA in a broad collection of structures is fairly uniform. The buildup of protein atoms of different types around the DNA provides new information for the improvement of nucleic acid force fields and fresh ideas for the exploration of the properties of DNA in solution.
Parental Reflective Capacities: A Scoping Review of Mindful Parenting and Parental Reflective Functioning
Authors: Huynh Tuyen , Kerr Margaret L. , Kim Christina N. , Fourianalistyawati Endang , Chang Vickie Ya-Rong , Duncan Larissa G.
Published: June 2024

Objectives

Two key parental reflective capacities—mindful parenting (MP) and parental reflective functioning (PRF) — have been shown to promote healthy parent-child relationships through parents’ increased sensitivity and responsiveness to their children’s needs in spite of parenting stressors. Despite the theoretical overlap between these two constructs, researchers have continued to examine them independently. Therefore, the purpose of this scoping review was to review the overlapping and distinctive outcomes and correlates in the empirical MP and PRF literatures.

Method

A comprehensive literature search across the MP and PRF literature for studies published from 2005 through early 2020 (pre-COVID-19 pandemic) was conducted.

Results

A review of 301 articles (n = 180 MP and n = 121 PRF) revealed overlapping study outcomes and correlates, including improvement in parent and child well-being, parenting behaviors, and attachment. Both MP and PRF literatures suggest MP and PRF are amenable to intervention-induced changes, although mostly documented in White mothers, which results may not be generalizable to diverse populations.

Conclusions

Researchers should consider the impact MP and PRF have on positive family relationships. Results suggest that scholars should consider investigating and intervening on MP and PRF simultaneously. Specifically, results identified MP and PRF convergent associations and perhaps synergistic impacts on positive parenting behaviors. Limitations and future directions are discussed.

Preregistration

This review was not preregistered.
Changes in Online Sexual Activities During the Lockdown Caused by COVID-19 in Spain: “INSIDE” Project
Authors: Ballester-Arnal Rafael , García-Barba Marta , Elipe-Miravet Marcel , Castro-Calvo Jesús , Gil-Llario Maria Dolores
Published: June 2024

Introduction

The lockdown, as a measure to stop the spread of COVID-19, has had an impact on different areas of our life, including sexuality. This study aims to analyze its impact on online sexual activities (OSAs) in people who lived in Spain during confinement.

Methods

This study involved 1448 people aged 18–60 years who were assessed through an online survey during confinement in Spain (April, 2020). The design of this study was a cross-sectional design, in which information on OSA before confinement and OSA, physical and social environment, and other variables related to gender and negative mood during confinement were collected at a single point in time.

Results

Our results show that both men and women, regardless of their sexual orientation, have experienced an increase in time and frequency invested in OSAs. In addition, individuals have also innovated their OSAs, for example, contacting sex workers. Factors such as high sexual desire, being a man, and consuming pornography were positively related to the frequency of ASOs during confinement, while high sexual desire and sexting were related to the time spent on ASOs during confinement.

Conclusions

The COVID-19 lockdown has had an impact on online sexuality. Both men and women have experienced an increase in their online sexual activity during confinement. In addition, some factors related to the increase in the time and frequency of OSAs are identified.

Policy Implications

Identifying how these changes have been during this very restrictive period and what factors related to the increase in OSAs can help us prevent possible consequences in similar scenarios.
Optimization of anionic dye removal using cross-linked chitosan composite as eco-friendly bio-adsorbent
Authors: Elhady Sarah , Bassyouni M. , Elshikhiby M. Z. , Saleh Mamdouh Y. , Elzahar Medhat H.
Published: June 2024

The environmental impact of wastewater discharged from the textile dyeing industry has a significant challenge and influence on aquatic ecosystems and human health if not properly managed. This study aimed to develop a novel cross-linked chitosan composite, denoted as chitosan/fly ash/polyvinyl alcohol (Ch/FA/PVA), as a bio-adsorbent for removing Congo Red (CR) textile dye from industrial wastewater. The synthesis involved the incorporation of FA into the chitosan matrix at various ratios to optimize the process. A specifically tailored composite, Ch/FA0.75/PVA, exhibited superior performance with a remarkable 99.7% CR removal under optimum conditions: adsorbent dose (0.9 g/l), contact time (50 min), and dye concentration (40 mg/l). The characterization of Ch/FA0.75/PVA through SEM–EDX, BET, FTIR, and pHzpc confirmed its suitability for adsorption. Employing Box–Behnken design and analysis of variance (ANOVA) facilitated the optimization of key adsorption variables. The Freundlich model described the adsorption equilibrium, indicating a maximum adsorption capacity of 263.15 mg/g for CR dye. The pseudo-second-order model demonstrated favorable kinetics. The study was scaled up to the practical application of Ch/FA0.75/PVA in a pilot plant for industrial wastewater treatment, revealing substantial removal percentages for dye, color, COD, BOD5 and TDS. This comprehensive approach highlights the promising efficacy of Ch/FA0.75/PVA in addressing environmental concerns associated with textile dye wastewater.
Nanomechanical and Structural Characteristics of Nanodiamond Composite Films Dependent on Target-Substrate Distance
Authors: Egiza Mohamed , Diab Mohamed Ragab , Murasawa Koki , Naragino Hiroshi , Yoshitake Tsuyoshi
Published: June 2024

This study explores the optimization of target-substrate distance (TSD) in coaxial arc plasma deposition technique for depositing nanodiamond composite (NDC) films on unheated WC–Co substrates, with a focus on enhancing properties relevant to cutting tool applications. TSD significantly impacted film growth and adhesion, while hardness and Young’s modulus remained stable within the 10–50 mm TSD range. Increased TSD led to reduced deposition rates and film thickness, but improved quality by eliminating macroparticles and reducing surface roughness. Notably, the NDC film deposited at 10 mm TSD exhibited exceptional adhesion resistance, a thickness of 11.45 μm, low compressive internal stress (2.8 GPa), and a surface roughness (Sa) of 280 nm, coupled with an impressive hardness of 49.12 GPa. This film also achieved a favorable deposition rate of 1.05 nm/s. In comparison, the film deposited at 15 mm TSD displayed a maximum hardness of 51.3 GPa, lower Sa of 179 nm, but a reduced deposition rate of 0.29 nm/s. The estimated C sp
3 fraction correlated well with the nanoindentation measurements, while internal stress showed a consistent relationship with film adhesion. These findings suggest that a TSD of 10 mm is optimal for balancing hardness, adhesion, deposition rate, and surface roughness, making NDC films a promising candidate for cutting tool applications.
Farmers’ evolving attitudes on environmental conditionality in the CAP: a farm level examination of temporal shifts
Authors: McCormack Michele , Buckley Cathal , Lynch Bridget
Published: June 2024

Given the anticipated shift in the allocation of resources under the common agricultural policy (CAP) toward increasing positive environmental outcomes, this study explores farmer attitudes toward the current principle of connecting direct payments to environmental conditionality, known as cross compliance. Furthermore, we explore whether there have been changes in farmer attitudes toward cross compliance over time by posing identical questions to farmers in both 2010 and 2018. A supplementary survey was designed and administered in conjunction with the core EU Farm Accountancy Data Network (FADN) to assess farmers’ attitudes to linking CAP payments to environmental conditionality. The findings of a generalized ordered logit model indicate a high level of support among farmers for linking direct payments to good agricultural practices and cross compliance standards. Factors influencing farmers’ acceptance of cross compliance can be categorized into several domains, including farm and farmer characteristics, social and institutional attributes, and economic factors. Notably, the level of subsidy dependency emerges as a highly significant factor, with farmers who rely more heavily on direct payments being more inclined to disagree with cross compliance requirements.
Health Effects of Occupational and Environmental Exposures to Nuclear Power Plants: A Meta-Analysis and Meta-Regression
Authors: Lin Ro-Ting , Boonhat Hathaichon , Lin Yu-Yu , Klebe Sonja , Takahashi Ken
Published: June 2024

Purpose of Review

Numerous epidemiological studies have shown increased health risks among workers and residents living near nuclear power plants exposed to radiation levels meeting regulatory dose limits. This study aimed to evaluate the association between radiation exposure and disease risks among these populations exposed to radiation levels meeting the current regulatory dose limits.

Recent Findings

We searched four databases (Cochrane Library, PubMed, ScienceDirect, and Web of Science) for studies published before August 2023, screened eligible studies (inclusion and exclusion criteria based on population, exposure, comparator, and outcome framework), and collected data on exposure indicators and disease risks. We applied random-effects models of meta-analysis to estimate the pooled effects and meta-regression to assess the dose-response relationship (radiation dose rate for workers and distance for residents). We identified 47 studies, 13 with worker and 34 with resident samples, covering 175 nuclear power plants from 17 countries, encompassing samples of 480,623 workers and 7,530,886 residents. Workers had a significantly lower risk for all-cancer and a significantly higher risk for mesothelioma. Residents had significantly higher risks for all-cancer, thyroid cancer, and leukemia. Notably, children under 5 years old showed the highest risk for all-cancer. Our meta-regression showed a significantly positive dose-response relationship between cumulative dose of radiation exposure and risk for circulatory disease among workers.

Our findings demonstrated higher risks for mesothelioma for workers and all-cancer, thyroid cancer, and leukemia for residents exposed to low-dose radiation from nuclear power plants. Some included studies did not adjust for cancer risk confounders, which could overestimate the association between radiation exposure and cancer risk and increase the risk of bias.
The Effect of Chemical Composition of Biological Solutions on the Tribocorrosive Behavior and Synergistic Wear of Titanium Grade V Alloys for Biomedical Applications
Authors: Ruggiero Alessandro , De Stefano Marco
Published: June 2024

Currently, the impact of tribocorrosion on medical devices such as dental implants has achieved notable effects since tribocorrosion is directly correlated with the longevity of the prosthesis. In a scenario where the phenomenon involves several variables, both from the tribological and chemical fields, this work aims to investigate the effect of the chemical compositions of biological solutions on the coupling of titanium grade V-alumina. The experimental tests were performed by a reciprocating tribometer equipped with a potentiostat and by a confocal/interferometric laser microscope connected with high-performance software for particle and wear analysis. The latter was evaluated by the synergistic approach, which is commonly adopted in the scientific community, as the sum of mechanical and synergistic effects. The results underlined that sodium lactate induced the greatest volume loss as much as the greatest tribocorrosive current and friction coefficient. On the other hand, the presence of salts such as sodium chloride and sodium bicarbonate also influenced the tribocorrosive response of titanium grade V alloys. In conclusion, the analytical equation considered for synergistic wear was modified by the introduction of a novel coefficient derived from the direct relationship between the friction coefficient and synergy and compared with the experimental data, providing a determination coefficient (R2) of 0.89.
Examining the nexus of blockchain technology and digital twins: Bibliometric evidence and research trends
Authors: Ma Xiaozhi , Du Wenbo , Li Lingyue , Liu Jing , Yuan Hongping
Published: June 2024

The integration of Blockchain Technology (BT) with Digital Twins (DTs) is becoming increasingly recognized as an effective strategy to enhance trust, interoperability, and data privacy in virtual spaces such as the metaverse. Although there is a significant body of research at the intersection of BT and DTs, a thorough review of the field has not yet been conducted. This study performs a systematic literature review on BT and DTs, using the CiteSpace analytic tool to evaluate the content and bibliometric information. The review covers 976 publications, identifying the significant effects of BT on DTs and the integration challenges. Key themes emerging from keyword analysis include augmented reality, smart cities, smart manufacturing, cybersecurity, lifecycle management, Ethereum, smart grids, additive manufacturing, blockchain technology, and digitalization. Based on this analysis, the study proposes a development framework for BT-enhanced DTs that includes supporting technologies and applications, main applications, advantages and functionalities, primary contexts of application, and overarching goals and principles. Additionally, an examination of bibliometric data reveals three developmental phases in cross-sectional research on BT and DTs: technology development, technology use, and technology deployment. These phases highlight the research field’s evolution and provide valuable direction for future studies on BT-enhanced DTs.
Advances and challenges in zirconia-based materials for dental applications
Authors: Han Mi-Kyung
Published: June 2024

Zirconia ceramics, as a category of metal oxide ceramics, stand out due to their impressive physicochemical and mechanical properties. Recognized for being bioinert, these ceramics are non-toxic, exhibit excellent biocompatibility, and offer superior mechanical strength. Moreover, zirconia’s natural aesthetic qualities enable it to closely mimic the appearance of natural teeth, making it an optimal choice for dental restorations, such as crowns, bridges, and veneers. This review examines the complex relationship between zirconia’s microstructure, including aspects like grain size, porosity, and phase composition, and how these factors impact its translucency and mechanical durability. A specific focus is on the critical role of the tetragonal phase in zirconia, spotlighting its contribution to the material’s superior mechanical strength and esthetic qualities. The stabilization of this phase, primarily through the use of yttria, is discussed for its dual influence on enhancing both the material’s strength and esthetic properties. Challenges such as low-temperature degradation (LTD) and discoloration are highlighted, along with potential solutions like advanced surface modifications and novel manufacturing techniques. The potential of flash sintering and 3D printing to further improve zirconia’s properties is also explored.
The Intensifying East China Sea Kuroshio and Disappearing Ryukyu Current in a Warming Climate
Authors: Yang Haiyuan , Cai Jinzhuo , Wu Lixin , Guo Haihong , Chen Zhaohui , Jing Zhao , Gan Bolan
Published: June 2024

The East China Sea Kuroshio (ECS‐Kuroshio) and the Ryukyu Current are the major poleward heat carriers in the North Pacific. Anomalous changes of ECS‐Kuroshio and Ryukyu Current could exert substantial influence on the climate in mid‐latitude regions. However, owing to limited observations and coarse resolution of climate models, how they might change under anthropogenic warming remains unknown. Here, we find an accelerating ECS‐Kuroshio (1.5 Sv) and a decelerating (−2.2 Sv) Ryukyu Current using in‐situ observation during 1958–2022, equivalent to 7% strengthening and 20% weakening in the 65 years. The trend is also simulated by four high‐resolution climate models, with multi‐model ensemble‐mean acceleration (deceleration) of the ECS‐Kuroshio (Ryukyu Current) of 1.2 ± 0.6 Sv (−6.2 ± 2.5 Sv) over 1950–2050. The weakening subtropical wind field reduces their summed transport o. Enhanced stratification, which induces uplift of current system and weaker topography‐flow interaction, leads to the intensifying ECS‐Kuroshio and disappearing Ryukyu Current.
Classification of Ground‐Based Auroral Images by Learning Deep Tensor Feature Representation on Riemannian Manifold
Authors: Hu Yangfan , Zhou Zeming , Yang Pinglv , Zhao Xiaofeng , Zhang Peng
Published: June 2024

Automatically classifying a huge amount of ground‐based auroral images is essential to facilitate aurora morphology statistical research and aid in comprehending the magnetospheric dynamics. However, facing the challenge of insufficient labeled images, deep learning methods perform suboptimally on small auroral image data sets, and traditional machine learning methods based on handcrafted features heavily rely on expert knowledge. In this paper, we propose a novel method that leverages the merits of both traditional machine learning and deep learning methods by extracting deep second‐order tensor features to train a support vector machine (SVM). To improve compactness and discriminative ability of the features, we comply the intrinsic data geometry on Riemannian manifold to employ dimensionality reduction and map the dimensionality‐reduced features from Riemannian space to Euclidean space for the SVM classifier. Experimental results on small aurora data sets conclusively demonstrate the effectiveness of our method, exhibiting competitive performance with recent aurora classification methods.
GOLD Observations of Equatorial Plasma Bubbles Reaching Mid‐Latitudes During the 23 April 2023 Geomagnetic Storm
Authors: Karan Deepak Kumar , Martinis Carlos R. , Eastes Richard W. , Daniell Robert E. , McClintock William E. , Huang Chao‐Song
Published: June 2024

A coronal mass ejection erupted from the Sun on 21 April 2023 and created a G4 geomagnetic storm on 23 April. NASA's global‐scale observations of the limb and disk (GOLD) imager observed bright equatorial ionization anomaly (EIA) crests at ∼25° Mlat, ∼11° poleward from their average locations, computed by averaging the EIA crests during the previous geomagnetic quiet days (18–22 April) between ∼15°W and 5°W Glon. Reversed C‐shape equatorial plasma bubbles (EPBs) were observed reaching ∼±36° Mlat (∼40°N and ∼30°S Glat) with apex altitudes ∼4,000 km and large westward tilts of ∼52°. Using GOLD's observations EPBs zonal motions are derived. It is observed that the EPBs zonal velocities are eastward near the equator and westward at mid‐latitudes. Model‐predicted prompt penetration electric fields indicate that they may have affected the postsunset pre‐reversal enhancement at equatorial latitudes. Zonal ion drifts from a defense meteorological satellite program satellite suggest that westward neutral winds and perturbed westward ion drifts over mid‐latitudes contributed to the observed latitudinal shear in zonal drifts.
The Wind‐Blown Sand Experiment in the Empty Quarter Desert: Roughness Length and Saltation Characteristics
Authors: Nelli Narendra , Francis Diana , Sow Mamadou , Fonseca Ricardo , Alkatheeri Abdulrahman , Bosc Emmanuel , Bergametti Gilles
Published: June 2024

The Empty Quarter Desert, one of Earth's major dust sources, frequently experiences dust storms due to wind erosion. Despite its significance as a primary dust source on a global scale, in‐situ observations from this region had not been reported until very recently. In summer 2022, the WInd‐blown Sand Experiment (WISE) Phase‐1 was initiated in the Empty Quarter Desert of the United Arab Emirates, and continued until 7 February 2023. Utilizing a diverse array of instruments, we measured winds, temperature, humidity, radiation fluxes, saltation, and the physical and optical properties of dust aerosols, atmospheric electric fields, and soil characteristics. A total of 38 distinct sand‐saltation events were recorded from September 2022 to February 2023, with activity peaking between 13:00 and 14:00 local time. Key findings include the identification of dominant wind patterns, and the measurement of the average aerodynamic roughness length (z0) at 0.8 ± 0.6 mm, and the thermal roughness length (zh) at 0.3 ± 0.5 mm—the first estimation of zh for this area. In‐situ observations revealed that dust particle concentrations near the surface increased 1.7‐fold on days with saltation compared to days without it. Moreover, we determined a wind‐speed threshold for initiating saltation at 7.70 m s−1. This comprehensive data set significantly advances our understanding of atmospheric‐soil interactions and sand movement dynamics, providing invaluable insights for ongoing research into desert environments and the global dust cycle.
What Happens in the Troposphere Doesn’t Stay in the Troposphere
Authors: Owen Rebecca
Published: June 2024

A new study suggests that spillover of tropospheric ozone is affecting measurements of stratospheric ozone recovery more than previously realized.
Impact of the Turbulent Vertical Mixing on Chemical and Cloud Species in the Venus Cloud Layer
Authors: Lefèvre Maxence , Lefèvre Franck , Marcq Emmanuel , Määttänen Anni , Stolzenbach Aurélien , Streel Nicolas
Published: June 2024

The Venusian atmosphere hosts a 10 km deep convective layer that has been studied by various spacecrafts. However, the impact of the strong vertical mixing on the chemistry of this region is still unknown. This study presents the first realistic coupling between resolved small‐scale turbulence and a chemical network. The resulting vertical mixing is different for each species: those with longer chemical timescales will tend to be well‐mixed. Vertical eddy diffusion due to resolved convection motions was estimated, ranging from 102 to 104 m2/s for the 48–55 km convective layer, several orders of magnitude above the typically used value. In the 48–55 km convective layer, the impact of the small‐scale turbulence on the cloud layer boundaries was between 200 m and 1 km. The impact of turbulence on cloud chemistry is consistent with Venus Express/Visible and Infrared Thermal Imaging Spectrometer observations. The observability at the cloud‐top of small‐scale turbulence by VenSpec‐U spectrometer would be challenging.
Warm Advection as a Cause for Extreme Heat Event in North China
Authors: Wang Xijin , Zhang Zhongshi , Yu Entao , Guo Chuncheng , Otterå Odd Helge , Counillon François
Published: June 2024

Extreme heat events (EHEs) often hit North China, resulting in significant losses. The devastating EHE in the 1743 summer, marked as the highest temperature in the past 300 years, led to ∼11,000 fatalities. These historical EHEs prompt us to explore potential mechanisms beyond anthropogenic influences. We employ the Norwegian Earth System Model here to simulate the past millennium climate and then dynamically downscale the July 1743 event using the Weather Research and Forecasting Model. The successful simulation of warming in North China, although it has been a fortunate outcome, is supported by tree‐ring records, providing a compelling case study for the event. Through composite and case analyses, we discover a connection between EHEs and active Northeast China Vortexes (NCVs) which induce warm advection, consequently heating the lower atmosphere. Reanalysis further confirms the connection in the modern era. Our study suggests modeling past EHEs, while challenging, is indeed feasible.
Asymmetrical Looping Magnetic Fields and Marsward Flows on the Nightside of Mars
Authors: Li Shibang , Lu Haoyu , Cao Jinbin , Cui Jun , Ip Wing‐Huen , Wild James A. , Zhang Xiaoxin , Chen Nihan , Song Yihui , Wang Jianxuan
Published: June 2024

As the interplanetary magnetic field (IMF) carried by the solar wind encounters the martian atmosphere, it tends to pile up and drape around the planet, forming looping magnetic fields and inducing marsward ion flows on the nightside. Previous statistical observations revealed asymmetrical distribution features within this morphology; however, the underlying physical mechanism remains unclear. In this study, utilizing a three‐dimensional multi‐fluid magnetohydrodynamic simulation model, we successfully reproduce the asymmetrical distributions of the looping magnetic fields and corresponding marsward flows on the martian nightside. Analyzing the magnetic forces resulting from the bending of the IMF over the polar area, we find that the asymmetry is guided by the orientation of the solar wind motional electric field (ESW). A higher solar wind velocity leads to enhanced magnetic forces, resulting in more tightly wrapped magnetic fields with an increased efficiency in accelerating flows as they approach closer to Mars.
The Atlantic Niño Mode: A Thermodynamic or a Dynamic Phenomenon?
Authors: Eusebi Borzelli Gian Luca , Carniel Sandro , Carniel Cosimo Enrico , Russo Aniello
Published: June 2024

The Atlantic Niño is an important source of the year‐to‐year variability of the tropical Atlantic, consisting in an irregular oscillation of the Sea Surface Temperature (SST) in the eastern tropical Atlantic. The physical mechanism underlying this oscillation is topic of debate. Some theories, known as dynamical, suggest that the Atlantic Niño is driven by internal wave dynamics. Other theories, termed thermodynamic, propose that the eastern tropical Atlantic SST variability is caused by thermodynamic processes associated with heat fluxes at the ocean surface and/or heat transport by oceanic currents. Here, we examine the SST variability from 1940 to 2022 and find that it can be described in terms of two spatial modes: one in the central and the other in eastern tropical Atlantic. However, focusing on the period from 1993 to 2022, these patterns behave differently. In 1993–2009 they concur in determining the eastern tropical Atlantic SST variability, while in 2010–2022 they act in opposite direction. Therefore, we use Sea Surface Height data and heat fluxes advected by oceanic currents to explore the relative contribution of wave dynamics and heat advection to the eastern tropical Atlantic SST fluctuation. We show that, between 1993 and 2010, the eastern tropical Atlantic SST variability is mainly determined by heat advected from the south by horizontal currents, while between 2010 and 2022 it can be explained in terms of wave dynamics. This finding suggests that the two spatial patterns determining the eastern tropical Atlantic SST variability, are two distinct physical phenomena forced by different physical mechanisms.
Nociceptive adenosine A2A receptor on trigeminal nerves orchestrates CGRP release to regulate the progression of oral squamous cell carcinoma
Authors: Jiang Lanxin , Zhou Ying , Tang Shijie , Yang Dan , Zhang Yixin , Zhang Jiuge , Yang Fan , Zhou Tong , Xia Xiaoqiang , Chen Qianming , Jiang Lu , Jiang Yuchen , Feng Xiaodong
Published: June 2024

Oral squamous cell carcinoma (OSCC) associated pain commonly predicts adverse events among patients. This clinical feature indicates the engagement of nociceptors on sensory neurons during the development of malignancy. However, it is yet to be determined if targeting oncometabolite-associated nociception processes can hinder OSCC progression. In this study, we reported that nociceptive endings infiltrating both clinical samples and mouse tumor xenografts were associated with poorer clinical outcomes and drove tumor progression in vivo, as evidenced by clinical tissue microarray analysis and murine lingual denervation. We observed that the OSCC microenvironment was characteristic of excessive adenosine due to CD73 upregulation which negatively predicted clinical outcomes in the TCGA-HNSC patient cohort. Notably, such adenosine concentrative OSCC niche was associated with the stimulation of adenosine A2A receptor (A2AR) on trigeminal ganglia. Antagonism of trigeminal A2AR with a selective A2AR inhibitor SCH58261 resulted in impeded OSCC growth in vivo. We showed that trigeminal A2AR overstimulation in OSCC xenograft did not entail any changes in the transcription level of CGRP in trigeminal ganglia but significantly triggered the release of CGRP, an effect counteracted by SCH58261. We further demonstrated the pro-tumor effect of CGRP by feeding mice with the clinically approved CGRP receptor antagonist rimegepant which inhibited the activation of ERK and YAP. Finally, we diminished the impact of CGRP on OSCC with istradefylline, a clinically available drug that targets neuronal A2AR. Therefore, we established trigeminal A2AR-mediated CGRP release as a promising druggable circuit in OSCC treatment.
Negative emotionality shapes the modulatory effects of ketamine and lamotrigine in subregions of the anterior cingulate cortex
Authors: Gärtner Matti , Weigand Anne , Meiering Marvin Sören , Weigner David , Carstens Luisa , Keicher Christian , Hertrampf Rita , Beckmann Christian , Mennes Maarten , Wunder Andreas , Grimm Simone
Published: June 2024

Neuroimaging studies have identified the anterior cingulate cortex (ACC) as one of the major targets of ketamine in the human brain, which may be related to ketamine’s antidepressant (AD) mechanisms of action. However, due to different methodological approaches, different investigated populations, and varying measurement timepoints, results are not consistent, and the functional significance of the observed brain changes remains a matter of open debate. Inhibition of glutamate release during acute ketamine administration by lamotrigine provides the opportunity to gain additional insight into the functional significance of ketamine-induced brain changes. Furthermore, the assessment of trait negative emotionality holds promise to link findings in healthy participants to potential AD mechanisms of ketamine. In this double-blind, placebo-controlled, randomized, single dose, parallel-group study, we collected resting-state fMRI data before, during, and 24 h after ketamine administration in a sample of 75 healthy male and female participants who were randomly allocated to one of three treatment conditions (ketamine, ketamine with lamotrigine pre- treatment, placebo). Spontaneous brain activity was extracted from two ventral and one dorsal subregions of the ACC. Our results showed activity decreases during the administration of ketamine in all three ACC subregions. However, only in the ventral subregions of the ACC this effect was attenuated by lamotrigine. 24 h after administration, ACC activity returned to baseline levels, but group differences were observed between the lamotrigine and the ketamine group. Trait negative emotionality was closely linked to activity changes in the subgenual ACC after ketamine administration. These results contribute to an understanding of the functional significance of ketamine effects in different subregions of the ACC by combining an approach to modulate glutamate release with the assessment of multiple timepoints and associations with trait negative emotionality in healthy participants.
Chemerin attracts neutrophil reverse migration by interacting with C–C motif chemokine receptor-like 2
Authors: Ji Jingjing , Zhong Hanhui , Wang Yawen , Liu Jinghua , Tang Jing , Liu Zhifeng
Published: June 2024

Neutrophil reverse migration (rM) is a recently identified phenomenon in which neutrophils migrate away from the inflammatory site back into the vasculature following initial infiltration, which involved in the resolution of loci inflammatory response or dissemination of inflammation. Present study was aimed to explore the mechanisms in neutrophil rM. By scRNA-seq on the white blood cells in acute lung injury model, we found rM-ed neutrophils exhibited increased gene expression of C–C motif chemokine receptor-like 2 (Ccrl2), an atypical chemokine receptor. Furthermore, an air pouch model was established to directly track rM-ed neutrophils in vivo. Air pouches were generated by 3 ml filtered sterile air injected subcutaneously for 3 days, and then LPS (2 mg/kg) was injected into the pouches to mimic the inflammatory state. For the rM-ed neutrophil tracking system, cell tracker CMFDA were injected into the air pouch to stain the inflammatory loci cells, and after 6 h, stained cells in blood were regarded as the rM-ed neutrophil. Based on this tracking system, we confirmed that rM-ed neutrophils showed increased CCRL2. We also found that the concentrations of the CCRL2 ligand chemerin in plasma was increased in the late stage. Neutralizing chemerin decreased the rM-ed neutrophil ratio in the blood. These results suggest that circulating chemerin attracts neutrophils to leave inflammatory sites by interacting with CCRL2, which might involve in the dissemination of inflammation.
Continuous sterane and phytane δ13C record reveals a substantial pCO2 decline since the mid-Miocene
Authors: Witkowski Caitlyn R. , von der Heydt Anna S. , Valdes Paul J. , van der Meer Marcel T. J. , Schouten Stefan , Sinninghe Damsté Jaap S.
Published: June 2024

Constraining the relationship between temperature and atmospheric concentrations of carbon dioxide (pCO2) is essential to model near-future climate. Here, we reconstruct pCO2 values over the past 15 million years (Myr), providing a series of analogues for possible near-future temperatures and pCO2, from a single continuous site (DSDP Site 467, California coast). We reconstruct pCO2 values using sterane and phytane, compounds that many phytoplankton produce and then become fossilised in sediment. From 15.0-0.3 Myr ago, our reconstructed pCO2 values steadily decline from 650 ± 150 to 280 ± 75 ppmv, mirroring global temperature decline. Using our new range of pCO2 values, we calculate average Earth system sensitivity and equilibrium climate sensitivity, resulting in 13.9 °C and 7.2 °C per doubling of pCO2, respectively. These values are significantly higher than IPCC global warming estimations, consistent or higher than some recent state-of-the-art climate models, and consistent with other proxy-based estimates.
A matched case-control analysis of autonomous vs human-driven vehicle accidents
Authors: Abdel-Aty Mohamed , Ding Shengxuan
Published: June 2024

Despite the recent advancements that Autonomous Vehicles have shown in their potential to improve safety and operation, considering differences between Autonomous Vehicles and Human-Driven Vehicles in accidents remain unidentified due to the scarcity of real-world Autonomous Vehicles accident data. We investigated the difference in accident occurrence between Autonomous Vehicles’ levels and Human-Driven Vehicles by utilizing 2100 Advanced Driving Systems and Advanced Driver Assistance Systems and 35,113 Human-Driven Vehicles accident data. A matched case-control design was conducted to investigate the differential characteristics involving Autonomous’ versus Human-Driven Vehicles’ accidents. The analysis suggests that accidents of vehicles equipped with Advanced Driving Systems generally have a lower chance of occurring than Human-Driven Vehicles in most of the similar accident scenarios. However, accidents involving Advanced Driving Systems occur more frequently than Human-Driven Vehicle accidents under dawn/dusk or turning conditions, which is 5.25 and 1.98 times higher, respectively. Our research reveals the accident risk disparities between Autonomous Vehicles and Human-Driven Vehicles, informing future development in Autonomous technology and safety enhancements.
Free-standing two-dimensional ferro-ionic memristor
Authors: Lee Jinhyoung , Woo Gunhoo , Cho Jinill , Son Sihoon , Shin Hyelim , Seok Hyunho , Kim Min-Jae , Kim Eungchul , Wang Ziyang , Kang Boseok , Jang Won-Jun , Kim Taesung
Published: June 2024

Two-dimensional (2D) ferroelectric materials have emerged as significant platforms for multi-functional three-dimensional (3D) integrated electronic devices. Among 2D ferroelectric materials, ferro-ionic CuInP2S6 has the potential to achieve the versatile advances in neuromorphic computing systems due to its phase tunability and ferro-ionic characteristics. As CuInP2S6 exhibits a ferroelectric phase with insulating properties at room temperature, the external temperature and electrical field should be required to activate the ferro-ionic conduction. Nevertheless, such external conditions inevitably facilitate stochastic ionic conduction, which completely limits the practical applications of 2D ferro-ionic materials. Herein, free-standing 2D ferroelectric heterostructure is mechanically manipulated for nano-confined conductive filaments growth in free-standing 2D ferro-ionic memristor. The ultra-high mechanical bending is selectively facilitated at the free-standing area to spatially activate the ferro-ionic conduction, which allows the deterministic local positioning of Cu+ ion transport. According to the local flexoelectric engineering, 5.76×102-fold increased maximum current is observed within vertical shear strain 720 nN, which is theoretically supported by the 3D flexoelectric simulation. In conclusion, we envision that our universal free-standing platform can provide the extendable geometric solution for ultra-efficient self-powered system and reliable neuromorphic device.
High resolution long-read telomere sequencing reveals dynamic mechanisms in aging and cancer
Authors: Schmidt Tobias T. , Tyer Carly , Rughani Preeyesh , Haggblom Candy , Jones Jeffrey R. , Dai Xiaoguang , Frazer Kelly A. , Gage Fred H. , Juul Sissel , Hickey Scott , Karlseder Jan
Published: June 2024

Telomeres are the protective nucleoprotein structures at the end of linear eukaryotic chromosomes. Telomeres’ repetitive nature and length have traditionally challenged the precise assessment of the composition and length of individual human telomeres. Here, we present Telo-seq to resolve bulk, chromosome arm-specific and allele-specific human telomere lengths using Oxford Nanopore Technologies’ native long-read sequencing. Telo-seq resolves telomere shortening in five population doubling increments and reveals intrasample, chromosome arm-specific, allele-specific telomere length heterogeneity. Telo-seq can reliably discriminate between telomerase- and ALT-positive cancer cell lines. Thus, Telo-seq is a tool to study telomere biology during development, aging, and cancer at unprecedented resolution.
Plasma proteomics identify biomarkers predicting Parkinson’s disease up to 7 years before symptom onset
Authors: Hällqvist Jenny , Bartl Michael , Dakna Mohammed , Schade Sebastian , Garagnani Paolo , Bacalini Maria-Giulia , Pirazzini Chiara , Bhatia Kailash , Schreglmann Sebastian , Xylaki Mary , Weber Sandrina , Ernst Marielle , Muntean Maria-Lucia , Sixel-Döring Friederike , Franceschi Claudio , Doykov Ivan , Śpiewak Justyna , Vinette Héloїse , Trenkwalder Claudia , Heywood Wendy E. , Mills Kevin , Mollenhauer Brit
Published: June 2024

Parkinson’s disease is increasingly prevalent. It progresses from the pre-motor stage (characterised by non-motor symptoms like REM sleep behaviour disorder), to the disabling motor stage. We need objective biomarkers for early/pre-motor disease stages to be able to intervene and slow the underlying neurodegenerative process. Here, we validate a targeted multiplexed mass spectrometry assay for blood samples from recently diagnosed motor Parkinson’s patients (n = 99), pre-motor individuals with isolated REM sleep behaviour disorder (two cohorts: n = 18 and n = 54 longitudinally), and healthy controls (n = 36). Our machine-learning model accurately identifies all Parkinson patients and classifies 79% of the pre-motor individuals up to 7 years before motor onset by analysing the expression of eight proteins—Granulin precursor, Mannan-binding-lectin-serine-peptidase-2, Endoplasmatic-reticulum-chaperone-BiP, Prostaglaindin-H2-D-isomaerase, Interceullular-adhesion-molecule-1, Complement C3, Dickkopf-WNT-signalling pathway-inhibitor-3, and Plasma-protease-C1-inhibitor. Many of these biomarkers correlate with symptom severity. This specific blood panel indicates molecular events in early stages and could help identify at-risk participants for clinical trials aimed at slowing/preventing motor Parkinson’s disease.
Climate change impacts on the extreme power shortage events of wind-solar supply systems worldwide during 1980–2022
Authors: Zheng Dongsheng , Tong Dan , Davis Steven J. , Qin Yue , Liu Yang , Xu Ruochong , Yang Jin , Yan Xizhe , Geng Guannan , Che Huizheng , Zhang Qiang
Published: June 2024

Economic productivity depends on reliable access to electricity, but the extreme shortage events of variable wind-solar systems may be strongly affected by climate change. Here, hourly reanalysis climatological data are leveraged to examine historical trends in defined extreme shortage events worldwide. We find uptrends in extreme shortage events regardless of their frequency, duration, and intensity since 1980. For instance, duration of extreme low-reliability events worldwide has increased by 4.1 hours (0.392 hours per year on average) between 1980–2000 and 2001–2022. However, such ascending trends are unevenly distributed worldwide, with a greater variability in low- and middle-latitude developing countries. This uptrend in extreme shortage events is driven by extremely low wind speed and solar radiation, particularly compound wind and solar drought, which however are strongly disproportionated. Only average 12.5% change in compound extremely low wind speed and solar radiation events may give rise to over 30% variability in extreme shortage events, despite a mere average 1.0% change in average wind speed and solar radiation. Our findings underline that wind-solar systems will probably suffer from weakened power security if such uptrends persist in a warmer future.
Cassini spacecraft reveals global energy imbalance of Saturn
Authors: Wang Xinyue , Li Liming , Jiang Xun , Fry Patrick M. , West Robert A. , Nixon Conor A. , Guan Larry , Karandana G Thishan D. , Albright Ronald , Colwell Joshua E. , Guillot Tristan , Hofstadter Mark D. , Kenyon Matthew E. , Mallama Anthony , Perez-Hoyos Santiago , Sanchez-Lavega Agustin , Simon Amy A. , Wenkert Daniel , Zhang Xi
Published: June 2024

The global energy budget is pivotal to understanding planetary evolution and climate behaviors. Assessing the energy budget of giant planets, particularly those with large seasonal cycles, however, remains a challenge without long-term observations. Evolution models of Saturn cannot explain its estimated Bond albedo and internal heat flux, mainly because previous estimates were based on limited observations. Here, we analyze the long-term observations recorded by the Cassini spacecraft and find notably higher Bond albedo (0.41 ± 0.02) and internal heat flux (2.84 ± 0.20 Wm−2) values than previous estimates. Furthermore, Saturn’s global energy budget is not in a steady state and exhibits significant dynamical imbalances. The global radiant energy deficit at the top of the atmosphere, indicative of the planetary cooling of Saturn, reveals remarkable seasonal fluctuations with a magnitude of 16.0 ± 4.2%. Further analysis of the energy budget of the upper atmosphere including the internal heat suggests seasonal energy imbalances at both global and hemispheric scales, contributing to the development of giant convective storms on Saturn. Similar seasonal variabilities of planetary cooling and energy imbalance exist in other giant planets within and beyond the Solar System, a prospect currently overlooked in existing evolutional and atmospheric models.