bluuebunny/crossref_metadata_2025 huggingface dataset:
Majocchi’s granuloma caused by Trichophyton rubrum in a type 2 diabetes patient and Review of Published Literature
Authors: Geng Hanqing , Bao Fangfang , Yang Baoqi
Published: April 2024

Background
Dermatophytosis caused by Trichophyton rubrum are common in dermatological disease, such as tinea manuum, tinea pedis, and tinea corporis. However, deep infection caused by T.rubrum was relatively rare in clinical. One of the types of Majocchi’ s granuloma (MG) is subcutaneous nodules that tends to happen to patients with an immunosuppression state.
Case presentation
The present report describes a case of MG caused by T.rubrum in a 59-year-old woman with a history of type 2 diabetes for five years. She had a red plaque appeared on the ring finger of left hand half a year ago and then the lymphatic vessels gradually develop upward into the forearm. MG was diagnosed by histopathological examination and fungal culture. We gave the patient oral itraconazole capsules 200 mg per day and naftifine cream for external use. One month later, the patient’s skin lesion was obvious subsided.
Conclusion
With a rising incidence rate of diabetes, clinical vigilance should be raised if patients with long-term medical history of diabetes. Increased sugar content in diabetic skin tissue and accumulation of glycation end products (AGEs), skin barrier function declined. Early diagnosis via accurate histopathological examination or fungal culture are vital for prompt treatment that results in better outcomes for the afflicted patients.
Modified Sanliangsan improved Sjogren’s syndrome complicated with interstitial lung disease by suppressing serum MUC1 levels
Authors: Tan Lihui , Lv Wang , Chen Yuqi , Dong Jianjian , Mao Dun , Wei Rong
Published: April 2024

Objectives
To clarify if the mechanism of Sanliangsan in improving Sjogren’s syndrome complicated with interstitial lung disease (SS-ILD) involves MUC1 suppression, which is involved in SS-ILD pathogenesis.
Methods
Fifty-six patients were randomly divided into two groups receiving Sanliangsan prescription therapy and conventional therapy. In-depth transcriptome profiles collected and analyzed to identify candidate genes involved in SS pathogenesis. Clinical symptom scores, metabolic compositions, lung HRCT scores, and serum MUC1 levels were compared between the two groups before and after treatment. Metabolome analyzed the metabolic composition of serum with SS-ILD before and after SP treatment.
Results
Transcriptome results identified the involvement of abnormal expression of genes relevant to the immune system, inflammatory responses, and signaling pathways. MUC1 was involved in SS pathogenesis and could be used to diagnose SS-ILD early. The SP therapy improved SS-ILD more effectively than conventional therapy. Moreover, Sanliangsan prescription therapy reduced serum MUC1 levels and restored the abnormal metabolisms, improving the abnormal inflammatory and immune responses of patients. Eugenol directly interacted with MUC1, and suppressed related genes, and was the bioactive compound of SP.
Conclusion
Modified Sanliangsan can improve the clinical symptoms, signs, and lung function of patients; the mechanism may be due to eugenol and related to MUC1 regulation
DNA barcoding of Andaman Padauk (Pterocarpus dalbergioides Roxb.,) an endemic tree species of Andaman and Nicobar Islands, India
Authors: Iyyappan Jaisankar , De Arun Kumar , Pari Prabhu , Ezekiel Manasseh Moses
Published: April 2024

The research investigates the genetic distinctiveness of Pterocarpus dalbergioides Roxb., commonly known as Andaman padauk, an endemic tree species of the Andaman and Nicobar Islands. The study employs DNA barcoding techniques, focusing on three barcode loci (ITS2, matK, and rbcL), to discern the species from closely related counterparts within the Pterocarpus genus. Sampling from 30 distinct locations across the Andaman and Nicobar Islands, genomic DNA isolation, PCR amplification, and sequencing were done. Polymorphism analysis revealed varying degrees of genetic diversity across the three barcode loci, with ITS2 demonstrating the highest discriminatory power. Phylogenetic analyses based on ITS2, matK, and rbcL sequences elucidated distinct species-specific clusters, reaffirming the endemic nature of P. dalbergioides to the Andaman and Nicobar Islands. Notably, ITS2 proved superior in species resolution compared to plastid barcodes (matK and rbcL). The study highlighted the utility of DNA barcoding in accurately identifying species, particularly in distinguishing closely related taxa within the Pterocarpus genus. The findings highlight the ecological and economic significance of P. dalbergioides as a valuable timber species and emphasize the importance of DNA barcoding in combating illegal trade and ensuring the sustainable management of endemic tree species. Overall, the research contributes to our understanding of the genetic diversity and conservation of P. dalbergioides, offering insights into its evolutionary relationships and aiding in the development of conservation strategies.
ARHGAP44 gene: a cytoskeleton mobility related modulator with potential implication in pan-cancer prognosis risk prediction and immune regulation
Authors: Shen Ningning , Yang Huijun , Wang Xuzhi , Du Juan , Miao Lei , Liu Siying , Yang Zhiqing , Gao Lifang , Ma Wenxia , Wang Chen
Published: April 2024

Background
Rho GTPases has been a well known family of small G proteins that regulate cellular cytoskeleton dynamics and involve in multiple critical steps of cancer progression. However, ARHGAP44 gene which is a member of GAP proteins that regulates the Rho GTPases cycling between their active GTP-bound and inactive GDP-bound state, its role in cancer development is still lack of understanding. The study is to analyze the function of ARHGAP44 gene in broad spectrum human cancers, thus aiding better understanding of the collaborative network of cytoskeleton related genes in cancers.
Methods
In the study, we started with the analysis of the genetic characteristics of ARHGAP44 gene, followed by its expression patterns, frequent alterations as well as survival prediction value in broad spectrum human cancers. Further, the probable reasons for the aberrant changed expression of ARHGAP44 in cancers comparing to corresponding normal control samples were investigated. Moreover, the correlation of ARHGAP44 with multiple critical clinical cancer parameters were in succession performed.
Results
Firstly, basic genetic physicochemical properties of ARHGAP44 including its aminoacid composition, estimated molecular weight and protein half life were investigated. Then, genetic alteration analysis revealed that ARHGAP44 expression various in human cancers, which was partly due to the modulation by DNA methylation and phosphorylation. Further, ARHGAP44 gene was indicated to be associated with multiple critical cancer traits including cancer stemness, cytoskeleton dynamics as well as immune infiltration in different human cancer types. Moreover, ARHGAP44 gene was also supported to be associated with the sensitivity of several chemotherapy related drugs.
Conclusions
Based on multiple analysis, some valuable strategies to guide the therapeutic orientation concerning the role of ARHGAP44 gene in human cancers were revealed, although more detailed experiments and clinical trials are obligatory to support further clinical medical application of the gene, especially in each independent type of cancers.
Transient local heterogenisation and regional homogenisation linked to dam-induced habitat loss in the Brazilian Atlantic riparian forests
Authors: Wuerges Mariah , Mantovani-Silva Eduarda , Peroni Nivaldo , Giehl Eduardo Luís Hettwer
Published: April 2024

Riparian forests are vital for biodiversity at local and regional scales, but dam construction for hydroelectric power alters these ecosystems, causing habitat loss and changing river dynamics. We investigate dam impacts on tree diversity in the southern Brazilian Atlantic Forest, sampling trees along riverbanks and uplands across 15 fragments affected by dams. We analyse the relationship between habitat loss, elevation difference, fragment size, and dam implementation time with alpha and beta diversity using mixed models and redundancy analyses. Habitat loss had a more significant impact on beta diversity than on alpha diversity, resulting in varied implications across spatial scales for riparian forests. The loss of local habitats led to a shift in the species composition of communities. As the intensity, spatial extent, and temporal scale of the impact intensified, communities exhibited diminished uniqueness. Meanwhile, alpha diversity displayed an increase solely in response to the local elevation differences between uplands and riverbanks. We propose that our sampling design is transferable to inadequately monitored systems to inform about beta diversity, a component of diversity which is still often neglected either on licensing stages or during mitigation of dam-related impacts. Furthermore, our findings indicate a transient local heterogenisation, which subsequently transitioned into biotic regional homogenisation, attributed to dam-induced habitat loss in the Brazilian Atlantic riparian forests.
RETRACTED: Effectiveness of the Tomatis® Method in Children with Autism Spectrum Disorder
Authors: Duranovic Mirela , Andrejas Matea , Kobelja Lidija , Klebic Jasmina
Published: April 2024

The authors have requested that this preprint be removed from Research Square.
Polarised crowd in motion: Insights into statistical and dynamical behavior
Authors: Jena Pratikshya , Mishra Shradha
Published: April 2024

The collection of active agents often exhibits intriguing statistical and dynamical properties, particularly when consid-
ering human crowds. In this study, we have developed a computational model to simulate the recent experiment on real
marathon races by Bain et al., [Science 363, 46–49 (2019)]. Our primary goal is to investigate the impact of race staff
on crowd dynamics. By comparing simulated races with and without the presence of race staff, our study reveals that
the local velocity and density of participants display a wave pattern akin to real races for both the cases. The observed
traveling wave in the crowd consistently propagates at a constant speed, regardless of the system size under consid-
eration. The participants’ dynamics in the longitudinal direction primarily contribute to velocity fluctuations, while
fluctuations in the transverse direction are suppressed. In the absence of race staff, density and velocity fluctuations
weaken without significantly affecting other statistical and dynamic characteristics of the crowd. Through this research,
we aim to deepen our understanding of crowd motion, providing insights that can inform the development of effective
crowd management strategies and contribute to the successful control of such events.
Percutaneous closure of the PFO through the right internal jugular vein using a non-steerable sheath: A Case Report
Authors: Wu Zhengbo , Wu Yang , Liu Yang , Hu Jiqiang
Published: April 2024

Paradoxical embolism is a significant cause of cryptogenic stroke (CS) in patients with patent foramen ovale (PFO). Venous embolism is typically found in the lower extremities. When venous access in the lower extremities is blocked, it can impede occlusion of the PFO and increase the risk of CS recurrence. This case report presents an unusual clinical scenario in a 60-year-old woman. The patient was admitted to the hospital for CS accompanied by migraine. The patent foramen ovale (PFO) was confirmed by agitated saline contrast echocardiography (ASCE). During the percutaneous PFO closure procedure, angiography indicated bilateral iliac vein occlusion, making the conventional vascular approach for PFO closure unusable. The right internal jugular vein was accessed using a non-steerable sheath and the Amplatzer PFO occluder (25/18mm) was successfully implanted for the patient. The position of the occluder was confirmed to be firmly fixed in the atrial septum by transthoracic echocardiography (TTE). One week of postoperative follow-up revealed no complications. Active blocking of PFO in CS patients with venous embolism can be beneficial. When the veins in the lower extremities are not accessible, it may be feasible to utilize the internal jugular veins in the upper body. Generally speaking, a non-steerable sheath is suitable for femoral vascular access in most PFO cases. When the femoral vascular approach is not accessible, a non-steerable sheath can be passed through the right internal jugular vein to complete the PFO occlusion procedure.
Spatiotemporal modeling of basin-scale pressure buildup from proximal commercial-scale CO 2 storage in stacked sequence of saline formations
Authors: Wijaya Nur , Morgan David , Vikara Derek , Grant Timothy , Liu Guoxiang
Published: April 2024

Commercial scale decarbonization through carbon capture and storage may likely involve many CO2 storage projects located in close proximity. The close proximity could raise concerns over caprock integrity associated with reservoir pressure buildup and interference among adjacent projects. Commercial-scale injection will also require large prospective CO2 storage resource and high injectivity in the targeted storage formations. To accommodate the need for both large resource and high injectivity, project operators could consider injecting CO2 into a stacked sequence of formations. This analysis investigates the benefits of injecting CO2 into a vertically stacked sequence of saline formations, over injecting the same amount of CO2 into a single saline formation, in addressing these challenges. Our analysis shows that injecting into the stacked sequence mitigates the extent of pressure buildup among the stacked formations, while still achieving the same or greater target CO2 storage volumes. Among cases modeled, the resulting pressure buildup front is most reduced when each storage site distributes injection volumes over several wells, each of which injects a portion of the total CO2 mass across the stacked sequence. This favorable case not only results in the smallest CO2 aerial footprint, but also shows the largest reduction in the pressure buildup at the top of perforation at the injection wells (upwards of approximately 46% compared to the single-formation storage), the result of which is crucial to maintain caprock integrity. This analysis provides insights into required decision-making when considering multi-project deployment in a shared basin.
Construction and analysis of the CDKN2B-AS1 ceRNA network associated with KRAS-dependent tumorigenesis in colorectal and pancreatic cancer
Authors: Saliani Mahsa , Javadmanesh Ali , Gonbadi Parisa , Rahimi Somayeh , Dastgir Faezeh , Daryasary Hadise Mirahmadi , Ghasemi Faezeh , Gharehdaghi Niusha , Ahmadian Mohammad Reza
Published: April 2024

Kirsten rat sarcoma viral oncogene homolog (KRAS) exhibits the highest mutation rate in colorectal cancer (CRC) and pancreatic cancer (PC), highlighting the need for a comprehensive understanding of KRAS-dependent pathogenesis. Given the regulatory role of long noncoding RNAs (lncRNAs) in gene expression, this study focused on constructing a competing endogenous RNA (ceRNA) network of selected KRAS-related lncRNAs. By analyzing the transcriptional profiles of CRC and PC cell lines with and without KRAS mutations, differentially expressed genes (DEGs) were identified using sequencing data from the Sequencing Read Archive database. Notably, the analysis revealed 42 common upregulated DEGs (uDEGs), including differentially expressed lncRNAs and protein-coding genes, between KRAS-mutant and KRAS-wild-type cells. Among them, CDKN2B-AS1 emerged as a key KRAS-related lncRNA for the construction of the ceRNA network. Using LncTarD, miRWalk, and ToppCluster servers, a robust ceRNA network of CDKN2B-AS1 was constructed to elucidate the interactions between corresponding miRNAs and target genes. This network included 21 miRNAs and 34 genes selected from common uDEGs. Enrichment analysis of ceRNA target genes validated their involvement in critical cancer-related pathways and biological processes. Crucially, expression and survival analysis underscored the prognostic significance of selected target genes within the CDKN2B-AS1 ceRNA network. By delineating the regulatory mechanisms of the CDKN2B-AS1 ceRNA network, this study sheds light on the molecular and cellular pathways involved in KRAS-associated tumorigenesis.
The key role of the youth in ongoing HIV-transmission: a community-based survey in KwaZulu-Natal, South Africa
Authors: Conan Nolwenn , Farhat Jihane Ben , Ohler Liesbet , Kenyon Chris , vanCutsem Gilles , Huerga Helena
Published: April 2024

New HIV infections among adults have decreased in the last ten years in high HIV prevalent countries. However, some groups of the population remain at high risk of HIV infection. We assessed the relation between sexual behavior, HIV awareness, antiretroviral therapy (ART) intake and viral suppression, and the age-gender groups the most at risk of maintaining HIV transmission in KwaZulu-Natal, South Africa. We performed an analysis, using data from participants aged 15–59 years of a population-based survey conducted in 2018. In total, 862 HIV-positive individuals were included, 10.1% were unaware of their HIV status, 15.8% not on ART and 16.3% virally unsuppressed. Overall, 10.6% had a high or very high risk of sexually transmitting HIV. Of them, 42.0% were women aged 20–34 years and 39.8% men aged 20–59 years, 50.0% were unaware of their status and 76.1% not on ART. Of the 2.3% individuals at very high risk of transmission, 68.4% were men aged 20–59 years. Efforts to increase HIV diagnosis, to detect early ART treatment failure, to provide enhanced adherence support and second- or third-line ART, as well as to promote behavioral-risk reduction interventions, are needed to reduce the pool of individuals at high risk of transmitting HIV.
Coal gangue as an efficient absorber for X-band applications
Authors: Zhu Chuanlei , Gao Shengtao , Zhang Yuanchun
Published: April 2024

Coal mining generates coal gangue (CG), whose poses considerable ecological challenges. Therefore, using CG in the preparation of electromagnetic wave (EMW)-absorbing materials has emerged as a promising approach for its high-value utilization. In this study, CG was dried and ball-milled. The microscopic morphology, element composition, elemental chemical state, and thermal stability of CG were characterized analyses. The EMW absorption performance of CG in the X-band was tested at filling ratios of 10%, 20%, and 40%. The results showed that CG mainly consisted of SiO2, Al2O3, and C. The CG/paraffin absorber exhibited strong reflection loss (RL) at a relatively thin thickness. When the thickness of the CG/paraffin absorber was 4.0 mm, the minimum RL reached − 50.2 dB at 8.8 GHz. The simulation results of the radar cross section showed that the absorbing coating can reduce EMW scattering on a perfectly conductive substrate, which renders it promising as an excellent EMW-absorbing material.
Targeting N4BP2L1 for Therapy in IPF and SSc-ILD: Evidence from Mendelian Randomization and Multi-Omics Analysis
Authors: Lv Xiaodi , Tang Weifeng , Ou Silin , Yang Fangyong , Wang Wenqian , Duan Xiaohong , Wei Ying
Published: April 2024

Background: Systemic sclerosis-associated interstitial lung disease (SSc-ILD) and idiopathic pulmonary fibrosis (IPF) are paradigmatic conditions characterized by similar pathogenic mechanisms involving inflammation and fibrosis. Both disorders present considerable challenges due to their elevated mortality rates and the difficulty in identifying effective treatments. Consequently, it is imperative to explore potential targets and deepen our understanding of the initiation and progression of these diseases.
Methods: To address this, we utilized a combination of Mendelian randomization (MR) analysis, single-cell RNA sequencing (scRNA-seq) analysis, and other multi-omics analysis.
Results: Our investigation confirmed the involvement of N4BP2L1 in CD8+ effector T (Teff) cells and its causal relationship with SSc-ILD. Subsequent multi-omics analyses were conducted to validate the role of N4BP2L1+ CD8+ Teff cells in the pathogenesis of both IPF and SSc-ILD. Through enrichment analysis, we unveiled the complex interplay among programmed necrosis, autophagy, and ferroptosis, highlighting their pivotal role in modulating the activity of N4BP2L1+ CD8+ Teff cells.
Conclusions: In essence, the heightened activity of N4BP2L1+ CD8+ Teff cells is implicated in the development of inflammation, fibrosis, and epithelial-mesenchymal transition (EMT), emphasizing its significance in the pathogenesis of both SSc-ILD and IPF.
Component Selection and Optimization of Solar Organic Rankine Cycle (ORC) for Low Heat Temperature or Industrial Waste Heat
Authors: TENBA RINCHIN SONAM , Deb Bharat
Published: April 2024

The increasing concerns over fuel prices and global warming have propelled the engineering industry to explore innovative solutions for reducing greenhouse gas emissions and enhancing energy efficiency. Among these solutions, the Organic Rankine Cycle (ORC) has emerged as a promising technology for low to medium temperature waste heat recovery in industrial processes. ORC offers advantages such as low capital cost, small size, easy maintenance, and the ability to convert low-grade heat into electricity.
This paper delves into the significance of ORC in addressing environmental challenges and improving production efficiency. It highlights the growing attention towards low-temperature waste heat recovery and emphasizes the ORC's role in converting heat into usable electrical energy. The benefits of ORC span industrial waste heat recovery, harnessing renewable energies, and low-power heat generation, making it an economically viable and environmentally friendly solution.
The study includes simulation results using DWSIM simulation software, presenting data on heat flow at different pressures for various working fluids. The analysis offers insights into the variation of heat flow with pressure, optimal operating conditions, and the stability of heat flow for each fluid. Additionally, the paper discusses the potential applications of ORC in rural electrification and its contribution to the renewable energy mix.
Furthermore, the research explores the benefits of ORC in different industries, such as refrigeration and air conditioning, and provides data on overall efficiency under different conditions. The findings indicate the potential for ORC to be utilized in diverse settings, including solar thermal, biomass, and geothermal applications.
The study concludes with an examination of SORC (Sorption Organic Rankine Cycle) efficiency for different working fluids under varying turbine inlet conditions. The analysis reveals the influence of turbine inlet pressure and temperature on efficiency, offering valuable insights for the optimization of ORC systems.
Developing conceptions of forgiveness across the lifespan
Authors: McLaughlin Abby , Marshall Julia , McAuliffe Katherine
Published: April 2024

Understanding how to respond to transgressions is central to cooperation, yet little is known about how individuals understand the consequences of these responses. Accordingly, the current study explored children’s (ages 5-9), adolescents’ (ages 11-14), and adults’ (N = 544, predominantly White, ~50% female, tested in 2021) understandings of three such responses¾forgiveness, punishment, and doing nothing. At all ages, participants differentiated between the consequences of these three responses. Forgiveness was associated with more positive and fewer negative outcomes, while the opposite was true for punishment and doing nothing. With age, participants were less likely to expect positive outcomes, and this effect was strongest for punishment and doing nothing. The results of this study allow novel insights into reasoning about three important response strategies.
Are there interindividual differences in the reactive hypoglycaemia response to breakfast? A replicate crossover trial
Authors: Gonzalez Javier T. , Lolli Lorenzo , Veasey Rachel C. , Rumbold Penny L.S. , Betts James A. , Stevenson Emma J.
Published: April 2024

Background
Following consumption of a meal, circulating glucose concentrations can rise and then fall briefly below the basal/fasting concentrations. This phenomenon is known as reactive hypoglycaemia but to date no study explored potential inter-individual differences in response to meal consumption.
Objective
We conducted a secondary analysis of existing data to examine inter-individual variability of reactive hypoglycaemia in response to breakfast consumption.
Methods
Using a replicate crossover design, 12 healthy men completed two identical control (continued overnight fasting) and two breakfast (444 kcal) conditions in randomised sequences. Blood glucose and lactate concentrations, serum insulin and non-esterified fatty acid concentrations, whole-body energy expenditure, carbohydrate and fat oxidation rates, and appetite ratings were determined before and 2 hours after the interventions. Inter-individual differences were explored using Pearson’s product-moment correlations between the first and second replicates of the control-adjusted breakfast response. Within-participant covariate-adjusted linear mixed models and a random-effects meta-analytical approach were used to quantify participant-by-condition interactions.
Results
Breakfast consumption lowered 2-h blood glucose 0.44 mmol/L (95%CI: 0.76 to 0.12 mmol/L) and serum NEFA concentrations, whilst increasing blood lactate and serum insulin concentrations (all p < 0.01). Large, positive correlations were observed between the first and second replicates of the control-adjusted insulin, lactate, hunger, and satisfaction responses to breakfast consumption (all r > 0.5, 90%CI ranged from 0.03 to 0.91). The participant-by-condition interaction response variability (SD) for serum insulin concentration was 11 pmol/L (95%CI: 5 to 16 pmol/L), which was consistent with the τ-statistic from the random-effects meta-analysis (11.7 pmol/L, 95%CI 7.0 to 22.2 pmol/L) whereas effects were unclear for other outcome variables (e.g., τ-statistic value for glucose: 0 mmol/L, 95%CI 0.0 to 0.5 mmol/L).
Conclusions
Despite observing reactive hypoglycaemia at the group level, we were unable to detect any meaningful inter-individual variability of the reactive hypoglycaemia response to breakfast. There was, however, evidence that 2-h insulin responses to breakfast display meaningful inter-individual variability, which may be explained by relative carbohydrate dose ingested and variation in insulin sensitivity of participants.
Award-winning Fruit Publication in ASHS Journals across the Decades (1986–2023)
Authors: Song Guo-qing
Published: April 2024

Established in 1903, the American Society for Horticultural Science (ASHS) is a leading professional organization that serves a diverse horticultural community. With influence spanning both national and global domains, ASHS makes substantial contributions to various branches of horticulture. In 1985, ASHS introduced the annual Fruit Publication Award to honor exceptional research articles related to fruit. Reflecting on these awarded articles, especially in light of ASHS’s 120-year history, not only serves as a congratulatory gesture to the recipients but also provides insight into the evolutionary progression of fruit science.
Twenty-five Years of Award-winning Education Publication Excellence in ASHS Journals
Authors: Rom Curt R.
Published: April 2024

The American Society for Horticultural Science Education Publication Excellence award was established in 1997 to recognize the most outstanding publication in ASHS journals related to education and teaching. This article reviews the award history, authors, and topics of the awarded papers. The award was recognized annually from 1998 to 2023 except for 3 years when no award was given. The majority of awarded papers were published in HortTechnology. Awards were presented to 70 authors from 23 institutions in 20 states and two other countries. Of the awarded papers, three had single authors, and 20 had multiple authors. Several awarded authors have been recognized in other ASHS publication awards or professional career awards. The majority of awarded papers focused on undergraduate students, teaching methods, and floriculture or ornamental topics.
Risk Assessment of Polycyclic Aromatic Hydrocarbons and Heterocyclic Aromatic Amines in Processed Meat, Cooked Meat and Fish-Based Products Using the Margin of Exposure Approach
Authors:   Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, Malaysia, Ab-Latif Nurin Irdina , Abdullah Rozaini ,   Department of Environmental and Occupational Health, Faculty of Medicine and Health Science, Universiti Putra Malaysia, Selangor, Malaysia, Omar Syaliza ,   Faculty of Pharmacy, Universiti Sultan Zainal Abidin, Besut Campus, Terengganu, Malaysia, Sanny Maimunah ,   Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, Selangor, Malaysia,   Laboratory of Food Safety and Food Integrity, Institute of Tropical Agricultural and Food Security, Universiti Putra Malaysia, Selangor, Malaysia
Published: April 2024

Background: The objective of this study is to assess the risk of exposure of polycyclic aromatic hydrocarbons (PAHs) and heterocyclic aromatic amines (HCAs) in meat and fish-based products marketed in Malaysia using the margin of exposure (MOE) approach. Methods: Benchmark Dose (BMD) software was used to model the BMD at a lower end of a one-sided 95% confidence interval with a 10% incremental risk (BMDL10) of PAHs and HCAs from different target organ toxicities. The MOEs of PAHs and HCAs in meat and fish-based products were determined by utilising the calculated BMDL10 values and estimated daily intake of meat and fish-based products from published data. Results: The calculated BMDL10 values of PAHs (i.e. benzo[a]pyrene [BaP] and fluoranthene [FA]) and HCAs (i.e. 2-amino-3,8,dimethylimidazo[4,5-f]quinoxaline [MeIQx] and 2-amino-1-methyl-6-phenylimidazo[4,5,6]pyridine [PhIP]) ranged from 19 mg/kg bw/day to 71,801 mg/kg bw/day. The MOE of BaP ranged from 41,895 to 71,801 and that of FA ranged from 19 to 1412. As for MeIQx and PhIP, their MOEs ranged from 6,322 to 7,652 and from 2,362 to 14,390, respectively. Conclusion: The MOEs of FA, MeIQx and PhIP were lower than 10,000, indicating a high concern for human health and therefore demanding effective risk management actions.
Peripherally Inserted Central Venous Catheter-Related Complications in Adult Patients with Haematological Malignancy
Authors:   Department of Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia, Kee Wei Lee , Chin Sum Cheong ,   Department of Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia, Gin Gin Gan ,   Department of Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia
Published: April 2024

Background: Peripherally inserted central venous catheters (PICC) are widely used in patients with haematological malignancies owing to the requirement for prolonged intravenous therapy. However, the growing use of PICCs has resulted in a multitude of complications such as infections and thrombosis, leading to prolonged hospitalisation periods and increased morbidity. This study aimed to determine the incidence of and factors associated with PICC-related complications in patients with haematological malignancies. Methods: This prospective cohort study was conducted at a single academic institution. The inclusion criteria involved all adult patients with haematological malignancies who had newly inserted PICCs. The patients were observed for a minimum duration of 60 days to evaluate the incidence of PICC-related infections and thrombosis, as well as mechanical complications. Results: A total of 119 PICCs were implanted in 85 patients. Among them, more than half of the patients were diagnosed with lymphoma (55.0%). The median dwell time was 61 days (interquartile range: 98 days). The incidence of PICC-related complications was 58.0% (6.9 per 1,000 catheter-days). Specifically, 43 PICCs (36.1%, 4.3 per 1,000 catheter-days) experienced infective complications, 25 (21.1%, 2.5 per 1,000 catheter-days) encountered mechanical complications and 1 (0.8%, 0.1 per 1,000 catheter-days) exhibited thrombotic complications. Furthermore, an underlying diagnosis of acute leukaemia was significantly associated with a higher incidence of PICC-related infections. Conclusion: Our study revealed higher incidence rates of PICC-related complications in adult patients with haematological malignancies compared to the finding of other studies. Notably, patients with underlying acute leukaemia displayed a higher incidence of PICC-related infections. These findings underscore the importance of implementing appropriate interventions and conducting thorough root cause analyses to effectively mitigate this complication and improve patient outcomes.
Kajian Bentuk Arsitektur Batak Toba dan Toraja sebagai Hasil Memori Kolektif Austronesia
Authors: Histanto Enrico Nirwan , Roosandriantini Josephine
Published: April 2024

Title: Study of Toba and Toraja Batak Architectural Forms as a Result of Collective Austronesian Memory
The archipelago (Indonesia) that we live in today is the distribution of the Austronesian people who lived in riverine areas in South China and North Vietnam in the mid-4th BC. Cultural development in an area results from a mixture of internal and external things. The mixing of culture and art by early settlers and new settlers resulted in diverse architectural forms, even though they share the same principles of traditional values (Austronesian collective memory). Toba and Toraja Batak architecture is hollow architecture with a similar roof shape that resembles the shape of a boat, a typology of houses and barns facing each other, and a housing complex oriented to form a particular axis. This research used an exploratory-qualitative approach, using literature sources combined with direct observations in the field. This research aims to find the level of closeness between Toba and Toraja Batak architecture based on the collective memory of the Austronesian people.
1950 Sonrası Türk Şiirinde “Kars” İmgesi
Authors: Abiç Taylan , Eyan Bilginç
Published: April 2024

Şehirler, içinde barındırdıkları ile toplumun varlık bütünlüğünü ve değerler dünyasının yansıma biçimini ortaya koyan mekânsal bir kimlik alanıdır. Anadolu’nun serhat şehirlerinden biri olan ve Türklerin Anadolu’ya yerleşmesi esnasında onlara Anadolu’nun kapılarının açıldığı yer olan Kars da benzer şekilde tarihî dönemlerden beri birçok toplumun varlık alanı olmuştur. Milat öncesi zamanlardan itibaren bir yerleşim yeri olarak kullanılan ve günümüzde ise mazisinden ve konumu itibariyle bu tarihin anlamını derinleştiren coğrafyasından güç alarak önemli imgeleri üzerinde toplamış olan Kars, Türk Edebiyatında müstakil olarak konu edinilen bir şehirdir. Bu işleniş biçimleri, yer yer farklılık gösterse de en temelde mekânsal bağlamda doğanın estetize edilmiş bir sunumunu ortaya koyar. Halk şiirleri ve hikâyeleri, roman, öykü gibi edebî türlerde birçok kez mekân olarak kullanılmış olan serhat şehri Kars, bu çalışmada çağdaş Türk şiirindeki işleniş biçimleri çerçevesinde değerlendirilmiş ve söz konusu şiirler, Kars’ın tarihi ve coğrafi yapısı düzleminde özne-varlık-mekân bağlamında analiz edilmiştir. İnceleme üç başlık altında Kars ile ilgili şiirlerin incelenmesi doğrultusunda metin merkezli olarak yapılmıştır. Kars temalı şiirlerde genel olarak kar ve kış mevsimi, yolculuk ve uzaklık gibi temalara rastlanmış, bu şiirlerin metaforik ve mitolojik bir söylem ile yapılandırıldığı gözlemlenmiş, kentten kırsala bakış, geleneksel şehir yapısı, varlık mekân ilişkisi, şiir-belge, yerel edebiyat, doğa, insan gibi kavramlar öne çıkmıştır.
Dîvânu Lugâti’t Türk’te Oluş Fiilleri: Çürümek Kavram Alanı
Authors: Eker Kavalçalan Özge
Published: April 2024

Bu çalışmada Dîvânu Lugâti’t Türk’teki çürümek kavram alanına giren oluş fiilleri ele alınmıştır. Çürüme, Türkçe Sözlükte mikroorganizmaların etkisiyle, kimyasal değişikliğe uğrayarak bozulup dağılmak, sağlamlığını, dayanıklılığını yitirmek veya vurulma, sıkışma yüzünden vücutta lekeler oluşması şeklinde tanımlanmaktadır. Çürüme, farklı kaynaklarda da cerahat, irin, sıkıntı veya mihnetten dolayı yıpranma, çökme ve yaşlanma gibi durumları da kapsamaktadır. Bu tanımlar çerçevesinde Dîvânu Lugâti’t Türk’teki canlı ve cansız varlıklara dair çürüme fiilleri ele alınmıştır. Söz konusu çürüme fiilleri, yiyecek, eşya, giyim- kuşam, mekân, doğa, insan ve hayvan yaşamındaki çürümek kavram alanı şeklinde sınıflandırılmıştır. Kavram alanı, aralarında ortak bir bağ bulunan isim ve fiil gibi sözlüksel unsurların bir arada sunulmasını sağlayan en önemli semantik araçlardan biridir. Bu bağlamda Dîvânu Lugâti’t Türk’te çürümeye dair oluş fiilleri kavram alanı çerçevesinde verilmiştir. Toplamda yüz otuz üç fiil tespit edilmiştir. Öte yandan Dîvânu Lugâti’t Türk’te çürümek kavram alanındaki fiiller –d(x), -(X)t-, -(X)ş-,+lA-n-, -(X)l, -g(X)r, +la-, -t(X)r-, -(X)n-, +laş- gibi farklı biçimbirimlerle çekimlenmiştir. Dolayısıyla bu çalışmada söz dizimsel yapı içerisindeki özne ve nesne ile kurulan bağlantılar da betimlenmiştir. Değerlendirme kısmında görüleceği üzere, tarihî Türk dilinin diğer metinlerine bakıldığında da çürümek kavram alanı fiilleri yapısal ve söz dizimsel kullanım açısından Dîvânu Lugâti’t Türk ile ortaklık göstermektedir.
Anahtar Kelimeler:
Bir Rönesans İnsanı Gazi Zahireddin Muhammed Babür’ün “Babürnâme” Eserinde Mimarlık ve İmar Dünyası
Authors: Hergül Çağlayan
Published: April 2024

Gazi Zahireddin Muhammed Babür, eseri Babürnâme ile yaşadığı dönemin tarihi, edebi ve kültürel alanındaki önemli bilgilere yer vermesiyle Türk-İslâm kültürü araştırmalarının önemli bir kaynağı olmuştur. Bu makalede çağının çok yönlü yanıyla “Rönesans İnsanı” imajına sahip olan Babür’ün, hatıratının izinde mimarlık ve imar dünyasına yönelik izlenimleri ve bakış açısının ortaya konması amaçlanmaktadır. Babürnâme kapsamında ele aldığımız çalışma Babür’ün anlatımlarının analizine dayanarak nicelik ve niteliksel çözümleme yöntemini içermektedir. Hatıratta anlatılanlar izinde Babür’ün mimariye bakış açısı “Kent Dokusu”, “Detaylı Anlattığı Yapılardan Örnekler”, “Kültürel Miras Kavramı”, “Kendi Yaptırdığı Eserlerden Örnekler” şeklinde dört alt başlıkta ele alınmıştır. Bu analizler nihayetinde Babür’ün mimari vizyonunun Türk-İslâm sanatı tarihi alanındaki katkısının ne derece önemli olduğunu ortaya koymaktadır.
Anahtar Kelimeler:
Training and Development of Strategic Talents in Kuzbass
Authors: Leukhova Maria , Starodubtseva Alina , Alabina Tatiana
Published: April 2024

Talent development is a strategic priority of talent management. It engages youth in the implementation of various strategies at different levels. The Kemerovo Region (Kuzbass) has created an entire ecosystem that raises young strategists. Kuzbass Governor Sergei Tsivilev set up the Department or Regional and Industrial Strategizing. Its goal is to promote the strategic guidelines stipulated in long-term plans of regional development, as well as to provide the region with strategic human resources. The Department is a joint project between the Lomonosov Moscow State University and the Kemerovo State University. The cooperation agreement was signed on November 7, 2019. In 2020, the Kemerovo State University launched a Master’s Degree program in Economic and Financial Strategy. Along with the Moscow State University and The National University of Science and Technology (MISiS), the Kemerovo State University became one of the three domestic institutions that were the first to start training specialists in strategizing. Professor Vladimir Kvint’s School of Young Strategists is an international academic project that identifies strategically gifted children and develops their strategic thinking. The Kemerovo Region is the current leader in the number of schools that participate in Vladimir Kvint’s School of Young Strategists.
Industrial Implementation of Digital Platforms: Strategizing Risks
Authors: Shabaeva Svetlana , Shabaev Anton
Published: April 2024

Even under the current foreign sanctions and external restrictions, Russia’s economic policy is aimed at industrial innovations. However, the ongoing digital transformation remains a serious challenge for timber enterprises: in fact, this industry demonstrates one of the lowest rates of digitalization. Digital transformation has both strategic advantages and strategic risks for such enterprises. If major business fails to consider these risks, the outcome can have long-term negative consequences. Effective strategizing of industrial enterprises needs special methods to identify, describe, and analyze strategic risks. The authors identified the strategic risks of digital transformation and summarized tools that could help timber and forestry enterprises to overcome them. The research relied on the theory and methodology of strategizing developed by Professor V.L. Kvint. According to this approach, a strategy does not identify problems: its main purpose is to identify opportunities, and opportunities always come with risks. The analysis systematized the general and specific features of ERP-systems and digital platforms as key elements of digital transformation. The article introduces opportunities and risks of digital transformation for timber industry enterprises, which must be taken into account by strategists. It also describes an automated process management model as a means of overcoming the risks.
Analysis of the association of the polymorphic locus rs3218536 of the xrcc2 gene with the risk of developing ovarian cancer in women from the Republic of Bashkortosta
Authors: Mingazheva Elvira Tagirovna , Valova Yana Valerievna , Prokofieva Daria Simonovna , Andreeva Ekaterina Anatolevna , Faishkhanova Rania Razyapovna , Khusnutdinova Elza Kamilevna
Published: April 2024

Ovarian cancer is the most aggressive form of all malignant neoplasms of the female reproductive system. Despite certain advances achieved in the diagnosis and treatment of this disease, survival rates are still unsatisfactory, which dictates the need for further study of the etiological factors and pathogenetic mechanisms underlying ovarian carcinogenesis. The purpose of the work was to conduct an association analysis of the rs3218536 polymorphic variant of the XRCC2 gene with the risk of developing ovarian cancer in women from the Republic of Bashkortostan. As a result of the study, it was not possible to detect an association of the studied polymorphic locus with the risk of developing ovarian cancer in women from the Republic of Bashkortostan
The possibilities of predicting of the preeclampsia on the modern level (literature review)
Authors: Pakhomov Sergey Petrovich , Golovchenko Oleg Vasilyevich
Published: April 2024

The preeclampsia is one of the main causes of maternal mortality. For this reason the issues of early diagnosis, and most importantly individual prediction are currently one of the most urgent aim for practical obstetrics. To the last years many ways has been attempted to creating methods of a personalized approach to the prognosis of the preeclampsia. However, until this day, the problem remains unresolved. This review article presents the most significant methods of individual prognosis of preeclampsia at the preclinical stage based on genetic, immunological and biochemical markers.
Nominal causal constructions: Causal chains and syncretism
Authors:   Institute for Linguistic Studies of the Russian Academy of Sciences, Say Sergey S.
Published: April 2024

Nominal causal constructions can involve dedicated markers (we arrived late because of John) or syncretic markers that can also convey concrete meanings, such as source (die from alcohol), goal, path, instrument/comitative, etc. So far, these patterns of syncretism have been systematically analyzed only for a few European languages. Based on a grammar survey of a world-wide variety sample of 65 languages, I assembled an annotated dataset of 113 nominal causal constructions. My goal was to explore whether patterns of syncretism correlate with specific types of causal meanings. The dataset provides evidence showing that such correlation does exist. In particular, syncretic markers that normally denote instruments or locations favour contexts where the caused event is simultaneous with the causing event (tremble with fear), while syncretic markers that normally denote endoints of motion favour contexts where the causing event is associated with future-oriented components in the causal chain. Overall, nominal causes tend to be construed in terms of simpler cognitive schemas, and the use of respective markers iconically reflects the structure of the relevant causal chains. By contrast, dedicated causal markers favour the meaning of indirect causation that involves speaker’s subjective reasoning. Typologically, dedicated markers are less frequent than syncretic markers. In individual languages, they are often of secondary origin and diachronically unstable. Thus, typologically and cognitively, dedicated causal markers are peripheral for the causal semantic domain, despite the fact that they are important for the European logic-oriented linguistic tradition.
How informal water supply points using private wells worked in an emergency: A quantitative evaluation
Authors: Endo Takahiro
Published: April 2024

The effectiveness of an emergency water supply using private wells has been asserted theoretically but not evaluated in detail. This paper aims to consider the effectiveness and shortcomings of emergency water supply based on local wells and to support policy formulation regarding groundwater usage in the event of a disaster. In Kamisu City, Ibaraki Prefecture, Japan, not only public-operated formal water supply points using water trucks but also informal water supply points using private wells were open to address water outages following the Great East Japan Earthquake of 2011. This study clarified the pattern of appearance and spatial distribution of those points by combining information from local newspapers, Internet archives, and an original questionnaire survey. In addition, the function of informal water supply points was quantitatively evaluated using GIS by comparing cases with and without informal water supply points. Analysis revealed that informal water supply points expanded the size of the serviced population within a 500-m radius of the water supply points by 47%, compared with cases when only formal water supply points were available. However, well water was not necessarily suitable for drinking owing to quality issues. As a policy lesson, the importance of sharing well information is indicated.