bluuebunny/crossref_metadata_2025 huggingface dataset:
US Food and Drug Administration Approval Summary: Capivasertib With Fulvestrant for Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Locally Advanced or Metastatic Breast Cancer With
PIK3CA
/
AKT1
/
PTEN
Alterations
Authors: Dilawari Asma , Buturla James , Osgood Christy , Gao Xin , Chen Wei , Ricks Tiffany K. , Schaefer Timothy , Avasarala Sreedevi , Reyes Turcu Francisca , Pathak Anand , Kalavar Shyam , Bhatnagar Vishal , Collazo Justin , Rahman Nam Atiqur , Mixter Bronwyn , Tang Shenghui , Pazdur Richard , Kluetz Paul , Amiri-Kordestani Laleh
Published: August 2024

PURPOSE

The US Food and Drug Administration (FDA) approved capivasertib in combination with fulvestrant for adult patients with hormone receptor–positive, human epidermal growth factor receptor 2 (HER2)–negative, locally advanced, or metastatic breast cancer (MBC) who have received at least one previous endocrine therapy and whose tumors harbor one or more phosphatidylinositol 3-kinase (
PIK3CA
)/AKT Serine/Threonine Kinase 1 (
AKT1
)/phosphatase and tensin homolog (
PTEN
) alterations, as detected by an FDA-approved test.

PATIENTS AND METHODS

Approval was based on CAPItello-291, a randomized, double-blind, multicenter trial of 708 patients with hormone receptor–positive, HER2-negative advanced or MBC, including 289 patients with
PIK3CA/AKT1/PTEN
tumor alterations. Patients were randomly assigned 1:1 to receive capivasertib 400 mg twice daily for 4 days per week with fulvestrant versus placebo with fulvestrant. Random assignment was stratified by presence of liver metastases, previous treatment with CDK4/6i, cyclin-dependent kinase four and six (CDK4/6) inhibitors, and geographical region.

RESULTS

A statistically significant progression-free survival (PFS) benefit was demonstrated in the overall population (hazard ratio [HR], 0.6 [95% CI, 0.51 to 0.71]); this result was driven by 289 patients in the biomarker-positive population (HR, 0.5 [95% CI, 0.37 to 0.68]). An exploratory analysis of investigator-assessed PFS in the 313 (44%) patients in the biomarker-negative population showed uncertain benefit (HR, 0.78 [95% CI, 0.60 to 1.01]). With capivasertib, more patients had Grade ≥3 toxicities. Key concerns included hyperglycemia (18% all-grade, 2.8% Grade ≥3), cutaneous toxicity (58% all-grade, 17% Grade ≥3), and diarrhea (72% all-grade, 9% Grade ≥3).

CONCLUSION

Capivasertib with fulvestrant was approved for patients whose tumors harbored
PIK3CA/AKT1/
PTEN
alterations. Benefit-risk assessment in this subgroup was favorable based on a statistically significant and clinically meaningful improvement in PFS in the context of an acceptable safety profile including no evidence of a potential detriment in overall survival. By contrast, the benefit-risk was unfavorable in the biomarker-negative population.
Subphenotypes in Acute Respiratory Distress Syndrome: Universal Steps Toward Treatable Traits
Authors: Filippini Daan F. L. , Smit Marry R. , Bos Lieuwe D. J.
Published: August 2024

Patients with acute respiratory distress syndrome (ARDS) have severe respiratory impairment requiring mechanical ventilation resulting in high mortality. Despite extensive research, no effective pharmacological interventions have been identified in unselected ARDS, which has been attributed to the considerable heterogeneity. The identification of more homogeneous subgroups through phenotyping has provided a novel method to improve our pathophysiological understanding, trial design, and, most importantly, patient care through targeted interventions. The objective of this article is to outline a structured, stepwise approach toward identifying and classifying heterogeneity within ARDS and subsequently derive, validate, and integrate targeted treatment options. We present a 6-step roadmap toward the identification of effective phenotype-targeted treatments: development of distinct and reproducible subphenotypes, derivation of a possible parsimonious bedside classification method, identification of possible interventions, prospective validation of subphenotype classification, testing of subphenotype-targeted intervention prospectively in randomized clinical trial (RCT), and finally implementation of subphenotype classification and intervention in guidelines and clinical practice. Based on this framework, the current literature was reviewed. Respiratory physiology, lung morphology, and systemic inflammatory biology subphenotypes were identified. Currently, lung morphology and systemic inflammatory biology subphenotypes are being tested prospectively in RCTs.
Six Paintings from Papunya
Authors: Gilchrist Stephen
Published: August 2024

The legacy of the Papunya painters of the 1970s, each of them senior men, has since been revitalized by their wives, sisters, and daughters—and by their sons, grandsons, and nephews. Art has been a crucial platform for Indigenous Australians to make their creative and cultural concerns legible to non-Indigenous peoples. Fred Myers and Terry Smith have long demonstrated their capacity to work with Indigenous artists and to translate their art for others. They assiduously follow Indigenous protocols relating to revelation and concealment. The six paintings under discussion actively communicate new and ancient knowledge to them and, through them, to the reader. Disciplinary divisions between anthropology and art history are overcome. A critical vocabulary best suited to apprehend these works is in the process of being shaped.
Include the females: morphology–performance relationships vary between sexes in lizards
Authors: Head Alyssa , Vaughn Princeton L. , Livingston Ethan H. , Colwell Cece , Muñoz Martha M. , Gangloff Eric J.
Published: August 2024

An animal's morphology influences its ability to perform essential tasks, such as locomoting to obtain prey or escape predators. While morphology–performance relationships are well-studied in lizards, most conclusions have been based only on male study subjects, leaving unanswered questions about females. Sex-specific differences are important to understand because females carry the bulk of the physiological demands of reproduction. Consequently, their health and survival can determine the fate of the population as a whole. To address this knowledge gap, we sampled introduced populations of common wall lizards (Podarcis muralis) in Ohio, USA. We measured a complete suite of limb and body dimensions of both males and females, and we measured sprint speeds while following straight and curved paths on different substrates. Using a multivariate statistical approach, we identified that body dimensions relative to snout-to-vent length in males were much larger compared with females and that body dimensions of P. muralis have changed over time in both sexes. We found that sprint speed along curved paths increased with relative limb size in both males and females. When following straight paths, male speed similarly increased as body dimensions increased; conversely, female speed decreased as body dimensions increased. Female sprint speed was also found to have less variation than that of males and was less affected by changes in body size and hindfoot length compared with males. This study thus provides insights into how selective pressures might shape males and females differently and the functional implications of sexual dimorphism.
Stable isotopes reveal sex- and context-dependent amino acid routing in green anole lizards (Anolis carolinensis)
Authors: Husak Jerry F. , Lailvaux Simon P.
Published: August 2024

Allocation of acquired resources to phenotypic traits is affected by resource availability and current selective context. While differential investment in traits is well documented, the mechanisms driving investment at lower levels of biological organization, which are not directly related to fitness, remain poorly understood. We supplemented adult male and female Anolis carolinensis lizards with an isotopically labelled essential amino acid (13C-leucine) to track routing in four tissues (muscle, liver, gonads and spleen) under different combinations of resource availability (high- and low-calorie diets) and exercise training (sprint training and endurance capacity). We predicted sprint training should drive routing to muscle, and endurance training to liver and spleen, and that investment in gonads should be of lower priority in each of the cases of energetic stress. We found complex interactions between training regime, diet and tissue type in females, and between tissue type and training, and tissue type and diet in males, suggesting that males and females adjust their 13C-leucine routing strategies differently in response to similar environmental challenges. Importantly, our data show evidence of increased 13C-leucine routing in training contexts not to muscle as we expected, but to the spleen, which turns over blood cells, and to the liver, which supports metabolism under differing energetic scenarios. Our results reveal the context-specific nature of long-term trade-offs associated with increased chronic activity. They also illustrate the importance of considering the costs of locomotion in studies of life-history strategies.
Compensation for Exercise Professional Services
Authors: Badaracco Christina , Durak Eric , Ward-Ritacco Christie L. , Ribley Douglas
Published: August 2024

Apply It!

• Consider preparing for a growing number of payment options for your patients and clients

• Engage in cross-sector collaboration to advance payment and reimbursement options to maximize access for your patients and clients

• Pursue professional certifications and document positive outcomes from your interventions to expand the evidence base for the value provided by our field of professionals
Factors influencing contraceptive uptake among women of reproductive age in Kenya
Authors: Nyakundi Jane Bitutu , Yonge Shadrack , Kiiru Samuel , Gichangi Peter
Published: August 2024

Background Modern Contraceptive Methods (MCM) use is among the interventions preventing unplanned pregnancies and unsafe abortions globally. Nevertheless, MCM uptake is still low. We aimed at determining factors influencing contraceptive uptake among women of reproductive age 15 to 49 years, in Kenya. Methods We used secondary data collected by Performance Monitoring for Action (PMA). PMA used cross sectional multi-stage cluster survey design and collected the data between November and December 2019. The study was approved by NACOSTI/202974 and KNERC KNH/ERC/R/192. Results The study obtained a sample size of 9477 women of reproductive age (WRA) from 11 counties in Kenya. Both descriptive and inferential statistical analysis with a P value of 0.05 was done using Stata 16.1. The prevalence of modern contraceptives uptake was 43.2% uptake was 43.2% among all WRA. The prevalence was lower among rural dwellers 41.4% (95% CI 39.62, 43.17) as compared to urban dwellers 47.5 (95% CI 44.39,50.55). More than half (53.4%) of the married women were using a modern contraceptive, while only about two in every 10 of the unmarried were using a modern contraceptive. Women affiliated with the Islam religion were less likely to use modern contraceptive (aPOR 0.6, 95% CI 0.42, 0.89 p=0.010) as compared to the Catholics. Family planning (FP) services were found to be lower (aPOR 0.535(95% CI 0.29,0.98 p=0.043) in National Hospital Insurance Fund (NHIF)-covered facilities than in non-NHIF-covered ones. Adolescent FP service provision and prescription was 4 times higher (aPOR 4.0 95% CI; 1.05,15.41, p=0.42) as compared to either the prescribed or provided. Conclusion Low uptake for MCM is influenced by sociodemographic factors and Health system factors. Efforts to increase MCM uptake should focus on rural residents, unmarried women, Islamic religion women and accreditation of NHIF services in all facilities.
A human model of Buruli ulcer: Provisional protocol for a Mycobacterium ulcerans controlled human infection study.
Authors: Muhi Stephen , Marshall Julia L. , O'Brien Daniel P. , Johnson Paul D.R. , Ross Gayle , Ramakrishnan Anand , Mackay Laura K. , Doerflinger Marcel , McCarthy James S. , Jamrozik Euzebiusz , Osowicki Joshua , Stinear Timothy P.
Published: August 2024

Critical knowledge gaps have impeded progress towards reducing the global burden of disease due to Mycobacterium ulcerans, the cause of the neglected tropical disease Buruli ulcer (BU). Development of a controlled human infection model of BU has been proposed as an experimental platform to explore host-pathogen interactions and evaluate tools for prevention, diagnosis, and treatment. We have previously introduced the use case for a new human model and identified M. ulcerans JKD8049 as a suitable challenge strain. Here, we present a provisional protocol for an initial study, for transparent peer review during the earliest stages of protocol development. Following simultaneous scientific peer review and community/stakeholder consultation of this provisional protocol, we aim to present a refined protocol for institutional review board (IRB) evaluation.
Classification and systematisation of fraud schemes identified in a financial statement audit
Authors: Sushkov Viktor
Published: August 2024

The paper evaluates the scale of fraud and analyzes the role of auditing in its detection. Differences between corporate fraud and fraud in the context of auditing are identified. Fraud schemes related to illegal appropriation of assets and fraudulent financial reporting, including improper asset valuation, timing differences, overstatement or understatement of revenues and expenses, as well as inadequate disclosure of information, are systematized. Each scheme is illustrated with examples. Special attention is given to the peculiarities of applying fraudulent schemes in the Russian accounting practice. The research results are intended to simplify the process of assessing the fraud risks and developing responsive procedures during the audit of financial statements. The developed methodological approaches may be of interest to practicing auditors and other professionals in the field of financial control and analysis.
Literary Reading Lessons Based on the Tale by P.P. Bazhov “Silver Hoof” (Part 1)
Authors: Novikova N. , Struchaeva T.
Published: August 2024

The article presents possible options for conducting literature lessons with third-graders. Younger schoolchildren are introduced to a new literary genre for them – a tale, represented by the work of P.P. Bazhov “Silver Hoof”. The teacher uses such technological teaching methods as creating a literary model, structural analysis of the text, working with an explanatory dictionary, compiling characteristics of literary heroes, role-playing reading, paired work of third-graders with proverbs.
Czarny ma tylko jeden los. I jest on biały – analiza problemów tożsamościowych społeczeństw afrykańskich w stosunkach międzynarodowych
Authors: Krzyżanowska-Skowronek Iwona
Published: August 2024

“BLACK HAS ONLY ONE FATE. AND IT IS WHITE” – AN ANALYSIS OF THE IDENTITY PROBLEMS OF AFRICAN SOCIETIES IN INTERNATIONAL RELATIONS
“Black Skin, White Masks” – the famous work of Franz Fanon is an elaborate analysis of the “Black-White” relationship, with the assumed emancipatory goal of releasing the coloured man from himself. His “black soul” is a white man’s social construct and it is impossible to get rid of it due to economic and political conditions and cultural subordination. Subsequent generations reproduced and/or superseded the problems of colonial subordination in various ways, but there is no doubt that identity attitudes still continue shaping the relationship between post-colonial communities and Western countries. I present the conclusions from Fanon’s reflections against the background of a short introduction to the issue of collective identities and the importance of their analysis for the study of international relations. The research goal of the article is to show how civilisational subordination disrupted the shaping of identity processes in colonised communities at the individual and collective level.
Efekty spillover chińskich inwestycji zagranicznych w Angoli i Zambii
Authors: Tycholiz Wojciech
Published: August 2024

SPILLOVER EFFECT OF THE CHINESE FDI IN ANGOLA AND ZAMBIAIn recent years, Chinese foreign direct investment (FDI) in Africa has attracted interest from both academia and the wider political world. Some postulate that Chinese companies – unlike Western corporations – have greater potential to initiate and carry out the structural transformation of the continent. Some researchers even indicate that thanks to the inflow of Chinese FDI, Africa may become “the next factory of the world”. The aim of this article is to analyse external effects (also called spillover effects) related to Chinese FDI in Africa using the examples of Angola and Zambia. According to the current state of knowledge, spillover effects are the most desirable effects of FDI in the host country, because the related increase in the productivity of local enterprises is key to the occurrence of structural transformation in local economies. The subject of the analysis presented in this article are three aspects (determinants) of spillover effects: (i) the potential of Chinese FDI to generate spillover effects, (ii) the absorptive capacity of local companies and (iii) local institutional settings favouring the occurrence of spillover effects. The findings indicate that due to the existence of weak and few linkages between foreign investors and local firms, spillover effects occur rarely and are relatively small. They are also not sufficient to initiate the transfer of valuable knowledge and technology. The presented research results were based on over 150 in-depth interviews and two rounds of surveys conducted among Chinese investors, Angolan and Zambian companies and representatives of local authorities.
Small intestinal obstruction secondary to migrated intragastric balloon retrieved endoscopically from the jejunum
Authors: Bamakhrama Khaled , Riyaz Suhana , Musthafa Mizna
Published: August 2024

Introduction: The intragastric balloon is a medical device inserted into the stomach endoscopically and filled with either air or more commonly, saline. Widely utilised since the 1980s, numerous studies have affirmed its safety and effectiveness as a temporary treatment for weight loss. Despite this, there have been reports of rare but severe complications associated with its usage. Case description: We report the case of a 33-year-old female presented with two-day history of epigastric pain, nausea and vomiting. This occurred after having a gastric balloon placed endoscopically two months earlier. A contrast-enhanced abdominal CT scan revealed a partially deflated and migrated intragastric balloon in the proximal jejunum, causing intestinal obstruction without any signs of bowel perforation. The diagnosis was established as intestinal obstruction due to the migrated intragastric balloon. An emergency endoscopic procedure was undertaken, successfully removing the balloon thus highlighting a unique attempt to endoscopically retrieve a migrated intragastric balloon from the jejunum. Conclusion: The efficacy of an intragastric balloon in reducing weight in a short time is gaining more popularity. The more common it becomes the more we must be vigilant about its complications. We advise regular follow-up of patients and emphasise patient education of possible signs and symptoms of intragastric balloon migration, which will avoid serious complications.
VALIDAÇÃO DE UM PRODUTO EDUCACIONAL EM FORMATO DEMANUAL DIDÁTICO ILUSTRADO SOBRE CURIOSIDADES, ANATOMIA E HISTOLOGIA DE SERPENTES
Authors: Tomé Gabriela Mariano , Marcelino Carolina Guarini , Marcelino Paula Guarini , Diniz Bruna Larissa Ramalho
Published: August 2024

O Ensino de Serpentes geralmente é abordado de modo superficial pois os livrosdidáticos possuem pouco aprofundamento sobre a temática, bem como a falta delaboratório ou equipamentos como lâminas e microscópio, fazendo com que os alunosnão tenham contato com a parte prática dos conteúdos de Anatomia e Histologia deSerpentes. Objetivou-se confeccionar e validar um Produto Educacional em formato deManual Didático ilustrado sobre Curiosidades, Anatomia e Histologia de Serpentes, composto de cinco oficinas de Ensino, como um possível recurso didático paraProfessores da Educação Básica. Este material foi avaliado por pares, Professores deCiências e Biologia, por meio de entrevistas online, os resultados avaliados de formaqualitativa por Análise Textual Discursiva (ATD). Os dados das entrevistas foramcategorizados em unidades de análise e subcategorias. Conclui-se que existem poucostrabalhos relacionados a recursos didáticos no Ensino de Serpentes, dados quecorroboram com a visão e prática dos professores entrevistados, uma vez que aabordagem de alguns conteúdos da temática baseia-se nas poucas informações oferecidasem livros didáticos disponíveis nas escolas. Deste modo, o Manual Didático sugeridoapresentou muitos pontos positivos por oferecer um conteúdo mais completo sobre a temática.
Analyzing the Influence of Safety Leadership, Work Pressure, and Safety Culture on Worker Safety Behavior in Steam Power Plant
Authors: Pamungkas Msy Cahaya D. , Dewi Ratna Sari
Published: August 2024

Workplace safety in coal-fired power plants in Sumatra, Indonesia, remains suboptimal, evident in the high incidence of work-related accidents leading to fatalities. This research acknowledges previous findings indicating that a significant portion of accidents is attributable to unsafe behavior. The aim of this study is to examine the combined impact of safety leadership, work pressure, safety culture, and safety behavior in a power plant in South Sumatra. Conducted at one of these facilities, the research utilized a questionnaire distributed to 102 respondents, with data analysis employing Structural Equation Modeling (SEM) through Partial Least Square (PLS). Results indicate that work pressure influences safety culture and safety behavior, safety leadership affects safety culture but insignificantly impacts safety behavior, and safety culture mediates the relationship between safety leadership, work pressure, and safety behavior. The implications of these findings provide guidance for companies to enhance safety behavior, emphasizing the establishment of a robust safety culture and effective safety leadership to prevent workplace accidents.
Design of Technical Evaluation Criteria for Procurement of Maintenance and Repair Services in Upstream Oil and Gas Companies
Authors: Wardana Febrita Kusuma , Lukitosari Valeriana
Published: August 2024

In the process of procuring services for the selection of contractors in upstream oil and gas companies that comply with PTK 007 SKK MIGAS regulations, an appropriate decisionmaking method is needed, in accordance with the scope and can be applied, where the technical evaluation assessment requires multiple criteria with respective weightings. Previous research has mostly been carried out in the construction and non-upstream oil and gas industries where the determination of criteria has not been precise and practical as needed which can affect technical evaluation failures. These multi-criteria decision-making methods use the Analytical Hierarchy Process (AHP) method, the results of which can be made into a mathematical model to determine the assessment of each potential winning contractor. The research began with identifying the criteria for previous research, the criteria currently used, and the classification of the appropriate criteria where the preparation was carried out using a questionnaire and a Forum Group Discussion (FGD) which was divided into 2 stages until each weighting criterion was obtained. This study resulted in 4 main criteria with 16 sub criteria where the main criteria with the highest weight was the ability to maintain and repair at 38.5%, with 2 sub criteria categorized as passed failed.
Designing User Interface and User Experience for Business Process Applications to Facilitate Digital Transformation in Oil and Gas Exploration
Authors: Indrajaya Helmi , Zulaikha Ellya
Published: August 2024

Indomigas, a national company that controls 67% of Indonesia's oil production, is undergoing a significant transformation amidst the global energy transition, digital disruption and organizational restructuring. Despite dominating the market, the company's exploration business processes were hampered by outdated and disconnected digital tools, leading to inefficiencies and inaccurate performance monitoring. This research focuses on strategic digital transformation in the Indomigas exploration division, which specifically aims to develop innovative user interfaces and business process user experiences. Using Design Thinking, this research developed through five phases, namely empathy, definition, ideation, prototyping, and testing. The research began by gathering user insights from in-depth interviews, focus groups, and literature. The final product is a prototype that meets company standards, offering a friendly, innovative solution that meets user needs. This initiative aims to transform exploration business processes, ensuring they are not only innovative and efficient but also increase operational efficiency, speed up decision making, and strengthen business management for Indomigas growth.
Sustainable Digital UX/UI Innovation Mobile Application Design for Bandar Ikat Weaning Msmes, Kediri City
Authors: Hardianti Adisty Riska , Akramullah Akramullah , Ramadhan Muhammad Bagus , Warisqianto Akbar , Bahar Moch. Fachruddin , Sholih Muhammad Syaifudding
Published: August 2024

Weaving Ikat Bandar Kediri is an MSME engaged in the production and sale of ikat woven fabric as well as an educational forum for ikat weaving located in Bandar sub-district, Kediri City, East Java, which sells conventionally and online via social media Instagram and WhatsApp. However, sales carried out online are still considered not to be running well, effectively, and efficiently. So a solution is needed to overcome the problems experienced by Ikat Weaving MSMEs in the form of developing more effective and organized marketing media to increase consumer attraction and product sales. The author recommends designing a user interface prototype and user experience of the Tenun Bandar Ikat mobile application with the aim of user comfort. This research aims to design and implement a more attractive and functional user interface presented in the Tenun Bandar Kediri (TBK) mobile application. This design aims to promote Bandar Kediri Ikat Weaving as branding for local products typical of the City of Kediri. The research results show that research has a positive influence on digital innovation in the development of sustainable local products based on MSMEs.
Circular Economy Business Model in High Frequency Welding Steel Pipe Company: A Case Study
Authors: Gunawan Maydawati Fidellia , Singgih Moses Laksono
Published: August 2024

Interest and attention to the circular economy business model have increased rapidly among policymakers, companies, entrepreneurs, and other stakeholders. Circular business models are believed and tested to produce benefits, such as reduced costs and environmental and social impacts. Existing research on circular business model innovation in steel manufacturing companies is still limited, especially in steel pipe manufacturing. In addition, research on applying existing circular business model innovations generally relates circularity to the closed product cycle flow. Based on the above problems, this research develops and selects alternative circular business model innovations in high-frequency welding steel pipe manufacturing companies using the DEMATEL and ANP integration approach. Nine criteria and eight alternative business models were developed based on the literature review. The research results show an alternative circular economy business model that can be applied in circular product and process design.
Integer Programming Application for Optimizing Line Balancing as Output Function in Bogie Carset Industry
Authors: Fathoni Muhammad Zainuddin , Siswanto Nurhadi
Published: August 2024

PT. BI is a company engaged in manufacturing bogie carset, at PT. BI, each work activity does not have the same operating time, and there is no standard time for each of its operations. Therefore, there is often an imbalance in each workstation. If continuous, it can lead to ineffective and inefficient production lines. The determination of production output is not well planned and only based on trial and error, resulting in the line's low efficiency. Mathematical integer programming will be used to determine the placement of activities on each workstation and the optimal output that can improve the efficiency of the track. This technique will be applied by taking a sample product from the company under study. The study showed a time efficiency of 25.81 minutes in line balancing side frame product. Meanwhile, there is a time efficiency of 1.745.9 minutes for bolstering product line balancing. The maximum output for side-frame products is 49 units/week, while the total number of bolster products is 29 units/week.
Information Technology Governance Audit at PT. Pelabuhan Indonesia III (Persero) with COBIT 5 Framework
Authors: Oktianatasari Heppy , Ginardi R. V. Hari
Published: August 2024

PT Pelabuhan Indonesia III (Pelindo 3) is improving its customer services by developing Information Technology (IT) solutions. The Sub Directorate Information Technology and Communication (Subdit TIK) Pelindo 3 implements IT Governance that has been regularly evaluated to optimize and align the solution developed to the company's business strategy. This research aims to obtain a measure of the current and expected capabilities of the IT process, specifically in Subdit TIK Pelindo 3, and to get recommendations to align IT governance with Pelindo 3's business strategy. The research method used is the COBIT 5 framework. The collected data is processed using a weighting method on the RACI Chart and a median value method for IT capability value. The result shows that the IT management capability level implemented in Subdit TIK Pelindo 3 mostly reaches only level 1, while the anticipated capability in 2018 is level 3. It means the company has not currently implemented a defined process or failed to achieve the objectives of the process. In this research, recommendations are developed to improve process capabilities to achieve the targeted capability level of IT management.
Application of Lean Concept on Replacement Process of Gauze Catalyst at PT Kaltim Nitrate Indonesia
Authors: Malik M. Sigit Awaludin , Karningsih Putu Dana
Published: August 2024

PT KNI is a foreign investment company that produces Ammonium Nitrate (AN), used as a component in explosive raw materials. During the early-stage production process, PT KNI faced the problem of replacing the Gauze Catalyst, which took a long time, causing the machine to experience downtime for 169 hours, or equivalent to a loss of USD 5,874,440. This problem is caused by non-value-added activities (waste) during the catalyst replacement process. Therefore, this study aims to identify waste and recommend corrective actions to reduce or eliminate them. This study adopts the lean approach by applying Process Activity Mapping and Root Cause Analysis (5 whys, Cause and Effect Diagram) to help identify non-value-added/wasteful activities and determine their root causes. The proposed improvements to address the root causes of waste include implementing 5S to make employees work more effectively and efficiently, developing Standard Operating Procedures (SOPs) that are in line with the current situation to facilitate employee work, adopting Vendor Managed Inventory (VMI) to build mutually beneficial business relationships between PT KNI and vendors, providing training to improve employee productivity, and ensuring the availability of tools, group communication, and a more ergonomic work environment. These improvements could eliminate wastage for 478 minutes and save USD 276,921.33 (4.72%) costs, thereby improving company performance.
Strategy For Increasing the Brand Reputation of The PLN Mobile Application Based on Social Media Sentiment Analysis Using Machine Learning
Authors: Riza Novi  Ainur , Santoso Bagus Jati
Published: August 2024

Social media is currently a trendy medium for people in Indonesia to express opinions. Users can easily express their experiences with a product through social media, including the PLN Mobile application from PT PLN (Persero). The application becomes a digital platform to meet various customer needs related to electricity services. Twitter social media has provided data on all tweets and reviews that can be accessed with certain keywords publicly through the Twitter API (Application Programming Interface). This research will use the text mining method with the word cloud approach, network explorer, types of emotions, and sentiment analysis, which can be used to analyze user opinions. The tools used are Orange Data Mining, which applies text preprocessing, including transformation, tokenization, normalization, and filtering, which aims to analyze text. The method used for sentiment analysis classification of Twitter users' opinions is VADER: Lexicon- and Rule-Based Sentiment Analysis. This method analyzes and classifies sentiment on social media towards the PLN Mobile application in Indonesia. The resulting classification model can be used as an early warning about how belief occurs on social media towards the PLN Mobile application. In addition, several recommendations on managerial aspects were also produced referring to the research data.
Community Perception of Effectiveness Climate Village Program Implementation in Overcoming Flood Problems in Surabaya City
Authors: Sari Ida Nur I. , Purnomo Jerry D. Trijoyo
Published: August 2024

Surabaya city as the second  metropolitan city cannot be separated from flood disaster. According  to  verification  team  PROKLIM  Lestari 2022, Surabaya is one of the cities designated as a role model for other villages. The appointment of Surabaya city as a role model is not in line with the occurrence of the flood disaster. Studies need to be carried out to measure the effectiveness level of the program. This study aims to measure community perceptions in assessing the effectiveness level of Climate Village Program to overcome the flooding problem in Surabaya using PLS-SEM method. The object of the research is people who felt the effects of flooding in Surabaya. This study uses public perceptions as exogenous variables, while the endogenous variables used were the level of effectiveness and  the implementation of PROKLIM. The results showed that the variable of public perception had an effect on the effectiveness and variable effectiveness had an effect on the PROKLIM implementation. So, it can be concluded that the government as a policy maker must always pay attention to the effectiveness of sustainability programs and the community can provide positive evaluations, program can run well, and the flood disaster can resolve.
Designing Data Governance With DAMA DMBOK Framework
Authors: Sigi Awit Lela
Published: August 2024

The vitality of data in aiding companies to fulfill their organizational objectives is paramount,  as  it  can  shape  decisions  across  a  variety  of  business  operations.  Often, corporations overlook the significance of data management, which in fact demands serious consideration. Two key issues that are frequently neglected include the hazy assignment of data responsibilities and the lack of robust data governance. The absence of transparency in data  sources  can  interfere  with  data  analysis  or  processing,  while  insufficient  data integration and synchronization can prolong report creation time up to three days, due to the need  to  accumulate  data  from  diverse  sources.  Furthermore,  the  use  of  Enterprise Architecture and Data Integration technologies has not reached its peak efficiency. To rectify these issues, it is recommended that PT XYZ adopts the DAMA DMBOK Framework for Data Governance. This would result in a well-organized and comprehensible data management structure. The procedure initiates with literature studies, progressing to plan data governance maturity evaluation activities, assessing data maturity levels using the DAMA   DMBOK,   generating   recommendations,   and   finally   planning   enhancement strategies for Data Governance in the company. The anticipated outcome of this study would be the provision of Data Governance recommendations utilizing the DAMA DMBOK framework
Procurement Strategies Using Kraljic Portfolio Model And Supplier Relationship Matrix in a Biomanufacturing Company
Authors: Prakosa Pebrian Tunggal , Pujawan I Nyoman
Published: August 2024

Uncertainty in the supply chain of Post-COVID-19 is a challenge for manufacturers. The risk of supply can be minimized if the company is able to place a robust strategy and establish good relationships with suppliers. Kraljic’s portfolio model is a popular approach for material classification. Research typically focus on a case study and modification in the matrix attribute or dimension. Research that combines Kraljic’s matrix and supplier relationship is still uncommon especially research on Bio-Manufacturing companies which have a large and complex variety of materials. This research aims to formulate the strategy and action plans in procurement. Data processing using the Multi-Dimensional Scaling approach. There are 19 types of materials researched, as well as 40 different suppliers. Kraljic matrix divides the material into four quadrants strategic, bottleneck, leverage, and noncritical quadrant. Procurement Strategies and Action plans developed from each materials quadrant. The Supplier relationship matrix divided the supplier of each material into four quadrants mutual attractiveness, supplier’s attractiveness, buyer’s attractiveness, and lack of attractiveness. By integrating Kraljic’s matrix and supplier relationship matrix resulting 3 strategies are Strategic, Collaborative, and transactional relationships. From three strategies develop 16 action plans. Gap analysis is used to compare the action plans with the existing condition. According to the research result can be shown the strategy to manage material and suppliers related with the condition of organization.
Risk Analysis on Documentation Unit Workload in Pharmaceutical Company using Failure Mode and Effect Analysis (FMEA)
Authors: Shufianti Henny , Sudiarno Adithya
Published: August 2024

Workload can affect employees in completing their work. Furthermore, mental workload can affect the documentation unit  performance since the  work is  monotonous,  does  not  require much physical movement and tends to be boring. There are 6 operators and 1 supervisor in the documentation unit. Due to its critical job, there are possibly risks that arise as a result of workload impact such as errors and delays in carrying out the documentation. Data from 2019 – 2022 shows there are an average of 8.61% delay documents per year and an average of 5.14% error check per year. In this study the researcher would like to figure out the mental workload condition and analyze the risks possibly occurred. Measurement of mental workload will be using NASA-TLX method. Then analyze the risk using the Failure Mode and Effect Analysis (FMEA) method. The result’s shows that the documentation operator have 75.60 score and categorized as moderate workload. The risk analysis is conducted using FMEA and the highest RPN number is 30 for error in checking document which will be the priority to mitigate. It is recommended to review and evaluate the risk after recommended action performed and analyze whether the risk can be eliminated or remains other risk.
Selection of Remote-Control Tie Switch Installation Location Using AHP-Promethee Method
Authors: Perdana Pramudya Nur , Ratnasari Vita
Published: August 2024

Remote-Control Tie Switch (RCTS) installation is one of the solutions that can be implemented to increase the reliability of the electric power distribution system. However, installing RCTS at all maneuvered points requires high investment costs, so it is necessary to prioritize locations based on sequence. In this research, there are 79 alternative locations and 5 criteria were used to prioritize RCTS locations. Alternatives based on the criteria produce different preferences, so these preferences must be measured first with Analytical Hierarchy Process (AHP). Then, Preference Ranking Organization Method for Enrichment Evaluation (Promethee) were used to get the location ranking order. The results of the AHP method show that the largest criterion weight is the number of customers (43,43%) and the smallest criterion weight is access to the location (4,64%), with a consistency ratio is 0,0787. The results of the Promethee method obtained the highest net flow value is the AMT02-KDG06 feeder maneuver point (0,415) and the lowest net flow value is the PLH03-PLH04 feeder maneuver point (-0,275). The results of the sensitivity analysis by increasing and decreasing the weight to 5%, 10% and 15% obtained no significant change in the rank position of the location and standard deviation.
Financial Feasibility Analysis of Cilampuyang Hydropower Plant Project (2X15 MW)
Authors: Saputra Muhammad Resky , Syairuddin Bambang
Published: August 2024

The Cilampuyang Hydropower Plant (2x15 MW) project is deemed feasible based on the financial analysis conducted. The electricity demand in West Java is projected to reach 20.1 million customers by 2030, with a growth rate of 3.27%. In light of the renewable energy policy, hydropower is considered a viable solution. The project is undertaken by PT Bangun Daya Utama and PT Bukaka Teknik Utama. According to the Renewable Power Generation Costs in 2021 report by IRENA, the construction costs for new hydropower plants from 2010 to 2021 ranged from USD 600/kW to USD 4,500/kW, equivalent to approximately Rp. 8,907,990/kW to Rp. 66,809,925/kW. Hence, the estimated costs for implementing the Cilampuyang Hydropower Plant project (2x15 MW) are substantial. Therefore, a financial analysis is crucial to determine the project's feasibility. This study aims to evaluate the economic viability and identify associated risks through the TPEM and LCOE investment feasibility analysis methods. Monte Carlo simulations were employed to assess project implementation risks. The research findings indicate that the TPEM and LCOE values for the Cilampuyang Hydropower Plant project are superior to the minimum required values. The NPV is Rp. 32,112,681,609,569, the IRR is 275%, and the LCOE is 0.013 USD/kWh. These results indicate that the investment in the Cilampuyang Hydropower Plant is financially viable. Furthermore, project implementation risks were measured using Mean NPV and minimum NPV parameters from 10,000 Monte Carlo simulations, yielding a Mean NPV of Rp. 33,867,831,000,000 and a minimum NPV of Rp. 26,331,417,000,000. In conclusion, the Cilampuyang Hydropower Plant presents a promising alternative for meeting the electricity needs in West Java while adhering to renewable energy policies. From an economic perspective, the investment in the Cilampuyang Hydropower Plant is feasible based on the favorable NPV, IRR, and LCOE values. However, project implementation risks should be considered based on known significant variables.
Audit Energy for Electricty Saving at PT XYZ
Authors: Sudarmakno Tri Puji , Irawan Mohammad Isa
Published: August 2024

PT XYZ is an integrated multinational engineering, procurement, construction, and installation company service provider. Production activities of PT XYZ require a very large amount of electrical energy. In 2022 electricity consumption will reach 35,459,867 kWh. The Commissioning Building + Deck erection area (Tr. 6D) Division is the area with the largest consumption, namely 8,720,628 kWh. The amount of electricity consumption has an impact on the increasingly expensive production costs. So, it is necessary to save electrical energy through an energy audit. Determination of Energy Saving Opportunities (PHE) in this study uses two calculations, namely Energy Consumption Intensity (IKE) and Specific Energy Consumption (KES). The data in this study is in the form of quantitative data obtained directly from PT XYZ which includes data on electrical energy, area, human resources, electrical installations, total energy consumption and total production in 2022 and during research from February 2023 to April 2023. After an energy audit was carried out and data on IKE and KES values obtained, then identify potential energy savings, which aims to determine the potential for Energy Saving Opportunities (PHE) electricity in the Division of Commissioning Building + Deck erection area (Tr. 6D) PT XYZ. Data analysis was carried out based on the results of energy audits and IKE and KES values. Saving electrical energy in the Division of Commissioning Building + Deck erection area (Tr. 6D) PT XYZ can save up to 15.14 % of electrical energy, so that it will have a significant impact on reducing production costs at the company.
Analysis Of Retailer Secured Channel Technology Platform Acceptance Model Using The UTAUT-2 Method
Authors: Wahyudin Asep , Suryani Erma
Published: August 2024

The national cement industry has experienced oversupply since 2017 coupled with the decline in national cement consumption during the pandemic, these conditions have made business competition in the cement sector increasingly stringent. PT XYZ is one of the companies that produce cement in Indonesia with a marketing and distribution network throughout the archipelago, 85% of the company's revenue is derived from the sale of cement products and the remaining 15% from non-cement products. During the Covid-19 pandemic, there was an increase in the penetration of online shopping for retail products and a change in people's behavior in transactions. The secured channel retailer technology platform built on a digital ecosystem at PT XYZ is expected to be able to increase the number of users and transactions that are still not optimally used by its customers, this has prompted the author to find out what factors influence the level of acceptance and use. In this study, the authors used the UTAUT 2 method by adding the Trust variable. Using the PLS-SEM and SmartPLS methods as data analysis software to test the research hypothesis using data samples from 184 respondents. The results of this study indicate that of the 11 hypotheses tested, 2 were rejected. The influence of Hedonic Motivation and Price Value on Behavioral Intention is not significant because, on the secured channel retailer technology platform, the retail products sold are basic materials, not an item that is a category of routine needs or needs for pleasure. The Trust variable (TR) has the greatest influence on Behavioral Intention (BI) at 62.5% and the Habit variable (HA) has the greatest influence on Use Behavior (UB) at 47.3%. Service providers need to focus on ensuring the security of users' data and learning new habits of users so that interest in using this technology increases.