bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy of Phenobarbital and Prognosis Predictors in Women With Epilepsy From Rural Northeast China: A 10-Year Follow-Up Study
Authors: Chu Chaojia , Li Nan , Zhong Rui , Zhao Danyang , Lin Weihong
Published: February 2022

Objective

To investigate the efficacy of phenobarbital (PB), factors associated with it, reasons for early treatment termination, and mortality rates in adult women living in rural Northeast China.

Methods

A prospective study was conducted in seven counties of Jilin Province from 2010 to 2020. Adult women diagnosed with convulsive epilepsy were recruited into the study and baseline demographics recorded upon enrollment. Seizure frequency, prescribed drug dose, and adverse reactions were monitored monthly by door-to-door survey or telephone interview.

Results

A total of 1,333 women were included in the study. During the follow-up period, 169 participants (12.7%) were lost to follow-up, and 100 of them (7.5%) died. The percentage of seizure-free participants was 45.3% in the first year, 74.6% in the third year, and 96.6% in the 10th year. A higher baseline seizure frequency (OR = 1.005, 95% CI: 1.002–1.009), more frequent loss-of-consciousness seizures (OR = 1.620, 95% CI: 1.318–1.990), a higher daily dose of PB in the first year (OR = 1.018, 95% CI: 1.014–1.022), a younger age at onset (OR = 0.990, 95% CI: 0.982–0.998), and more severe drowsiness (OR = 1.727, 95% CI: 1.374–2.173) were associated with an increased risk of seizures in the first year, and the higher baseline seizure frequency was still associated with the occurrence of seizures in the third (OR = 1.007, 95% CI: 1.004–1.010) and fifth year (OR = 1.005, 95% CI: 1.002–1.008). Age at enrollment (HR = 0.983, 95% CI: 0.971–0.994) was the only factor that correlated with withdrawal from the study and with the death of the participant during the follow up period, but the correlation in each case was in opposite directions.

Significance

PB has high effectiveness, retention rate, mild side effects, and tolerability when used as a treatment for epilepsy in women from rural areas. Baseline seizure frequency is an important predictor of prognosis regardless of treatment duration. PB is still a valuable tool for the management of epilepsy in adult women from poverty-stricken areas.
Primary School Children’s Self-Reports of Attention Deficit Hyperactivity Disorder-Related Symptoms and Their Associations With Subjective and Objective Measures of Attention Deficit Hyperactivity Disorder
Authors: Slobodin Ortal , Davidovitch Michael
Published: February 2022

Background

The diagnosis of Attention deficit hyperactivity disorder (ADHD) is primarily dependent on parents’ and teachers’ reports, while children’s own perspectives on their difficulties and strengths are often overlooked.

Goal

To further increase our insight into children’s ability to reliably report about their ADHD-related symptoms, the current study examined the associations between children’s self-reports, parents’ and teachers’ reports, and standardized continuous performance test (CPT) data. We also examined whether the addition of children’s perceptions of ADHD-symptoms to parents’ and teachers’ reports would be reflected by objective and standardized data.

Methods

The study included 190 children with ADHD, aged 7–10 years, who were referred to a pediatric neurologic clinic. A retrospective analysis was conducted using records of a clinical database. Obtained data included children’s self-reports of their attention level and ADHD-related symptoms, parent, and teacher forms of the Conners ADHD rating scales, Child Behavior Checklist (CBCL), Teacher’s Report Form (TRF), and CPT scores.

Results

Children’s self-evaluations of their functioning were globally associated with their teachers’ and parents’ evaluations, but not uniquely. Children’s self-reports of ADHD symptoms were not uniquely linked to a specific CPT impairment index, but to a general likelihood of having an impaired CPT. The CPT performance successfully distinguished between the group of children who defined themselves as inattentive and those who did not.

Conclusion

Primary school children with ADHD are able to identify their limitations and needs difficulties and that their perspectives should inform clinical practice and research. The clinical and ethical imperative of taking children’s perspectives into account during ADHD diagnosis and treatment is highlighted.
Landscape of TP53 Alterations in Chronic Lymphocytic Leukemia via Data Mining Mutation Databases
Authors: Soussi Thierry , Baliakas Panagiotis
Published: February 2022

Locus-specific databases are invaluable tools for both basic and clinical research. The extensive information they contain is gathered from the literature and manually curated by experts. Cancer genome sequencing projects generate an immense amount of data, which are stored directly in large repositories (cancer genome databases). The presence of a TP53 defect (17p deletion and/or TP53 mutations) is an independent prognostic factor in chronic lymphocytic leukemia (CLL) and TP53 status analysis has been adopted in routine clinical practice. For that reason, TP53 mutation databases have become essential for the validation of the plethora of TP53 variants detected in tumor samples. TP53 profiles in CLL are characterized by a great number of subclonal TP53 mutations with low variant allelic frequencies and the presence of multiple minor subclones harboring different TP53 mutations. In this review, we describe the various characteristics of the multiple levels of heterogeneity of TP53 variants in CLL through the analysis of TP53 mutation databases and the utility of their diagnosis in the clinic.
ORMDL3 Promotes Angiogenesis in Chronic Asthma Through the ERK1/2/VEGF/MMP-9 Pathway
Authors: Ding Zhen , Yu Fei , Sun Yan , Jiao Ning , Shi Lina , Wan Jinghong , Liu Qinghua
Published: February 2022

Aim

Angiogenesis plays a vital role in airway remodeling in chronic asthma. ORMDL3 has been identified to be closely associated with the development of asthma remodeling. This study was to investigate the mechanism of ORMDL3 in angiogenesis of chronic asthma.

Methods

BALB/c mice were divided into three groups, including an asthmatic group (group A), a budesonide-treated group (group B), and a normal control group (group C). Hematoxylin and eosin and Masson staining were used to evaluate the pathological changes. Angiogenesis in lung tissue was examined by CD31 staining. The changes of ORMDL3, ERK1/2, and angiogenesis-associated MMP-9 and Vascular endothelial growth factor (VEGF) expression were examined. Furthermore, ORMDL3, MMP-9, and VEGF mRNA and protein levels were examined after transfection in BEAS-2B cells with the ORMDL3-overexpressed lentiviral vector.

Results

Compared with the control group, asthmatic mice indicated more severe airway angiogenesis with increased ORMDL3, ERK1/2, MMP-9, and VEGF expression. Budesonide alleviated airway angiogenesis, and CD31 expression was positive with the levels of ORMDL3, MMP-9, and VEGF (P < 0.01). After successful transfection in BEAS-2B cells with the ORMDL3-overexpressing lentiviral vector, VEGF, and MMP-9 expression were activated in vitro (P < 0.01).

Conclusion

In conclusion, our study provides novel evidence that ORMDL3 promotes angiogenesis through upregulating VEGF and MMP-9 in chronic asthma.
Accessibility of Essential Medicines for Children in Sichuan Province of China: A Cross-Sectional Study
Authors: Chen Zhe , Li Siyu , Choonara Imti , Zeng Linan , Jia Zhi-jun , Cheng Guo , Yu Qin , Zhang Lingli
Published: February 2022

Background: Essential medicines for children are those medicines that satisfy the priority health care needs of children. Access to essential medicines for children is a big challenge, particularly in low- and middle-income countries. Our study aimed to assess the accessibility of essential medicines for children in public sector in Sichuan Province of China, based on availability, affordability, and price.

Methods: We adopted the modified World Health Organization/Health Action International (WHO/HAI) standardization methodology to measure the availability, affordability, and prices of 30 essential medicines for children in 20 public hospitals in nine regions of the Sichuan Province, China. Availability was expressed as the percentage of public medicine outlets that stocked surveyed medicines on the day of data collection, and prices were expressed as median price ratio (MPR). Affordability was assessed as the number of Sichuan Province’s daily wages required for the lowest-paid government unskilled worker (11.03 USD per day) to purchase one standard treatment of an acute disease or treatment for chronic disease for a month.

Results: The mean availability of originator brands (OBs) and lowest priced generics (LPGs) were 9.7 and 46.5% in public sector. MPRs of only 3 OBs could be calculated, ranging from 0.55 to 13.37. MPRs of 18 LPGs ranged from 0.07 to 25.05. Among them, 2 OBs and 11 LPGs were priced at more than 1.5 times their international reference prices (IRPs) in public sector, most of which were injections. Except for cefazolin injection and ceftriaxone injection, most LPGs were affordable for the treatment of childhood diseases in public sector, as they each cost one or less than the daily wage for the lowest-paid unskilled government worker.

Conclusions: Although the availability of LPGs for children was higher than OBs in public sector, the availability of children’s essential medicines was low in surveyed public sector in Sichuan Province, which was similar to previous studies in other provinces of China. The price of most medicines surveyed was higher than their IRPs in surveyed public sector, especially for some injections. The affordability of most surveyed LPGs was reasonable in surveyed public sector, except for ceftriaxone injection and cefazolin injection.
Augmented Cardiac Growth Hormone Signaling Contributes to Cardiomyopathy Following Genetic Disruption of the Cardiomyocyte Circadian Clock
Authors: Sonkar Ravi , Berry Ryan , Latimer Mary N. , Prabhu Sumanth D. , Young Martin E. , Frank Stuart J.
Published: February 2022

Circadian clocks regulate numerous biological processes, at whole body, organ, and cellular levels. This includes both hormone secretion and target tissue sensitivity. Although growth hormone (GH) secretion is time-of-day-dependent (increased pulse amplitude during the sleep period), little is known regarding whether circadian clocks modulate GH sensitivity in target tissues. GH acts in part through induction of insulin-like growth factor 1 (IGF1), and excess GH/IGF1 signaling has been linked to pathologies such as insulin resistance, acromegaly, and cardiomyopathy. Interestingly, genetic disruption of the cardiomyocyte circadian clock leads to cardiac adverse remodeling, contractile dysfunction, and reduced lifespan. These observations led to the hypothesis that the cardiomyopathy observed following cardiomyocyte circadian clock disruption may be secondary to chronic activation of cardiac GH/IGF1 signaling. Here, we report that cardiomyocyte-specific BMAL1 knockout (CBK) mice exhibit increased cardiac GH sensitivity, as evidenced by augmented GH-induced STAT5 phosphorylation (relative to littermate controls) in the heart (but not in the liver). Moreover, Igf1 mRNA levels are approximately 2-fold higher in CBK hearts (but not in livers), associated with markers of GH/IGF1 signaling activation (e.g., p-ERK, p-mTOR, and p-4EBP1) and adverse remodeling (e.g., cardiomyocyte hypertrophy and interstitial fibrosis). Genetic deletion of one allele of the GH receptor (GHR) normalized cardiac Igf1 levels in CBK hearts, associated with a partial normalization of adverse remodeling. This included attenuated progression of cardiomyopathy in CBK mice. Collectively, these observations suggest that excessive cardiac GH/IGF1 signaling contributes toward cardiomyopathy following genetic disruption of the cardiomyocyte circadian clock.
Dehazing Based on Long-Range Dependence of Foggy Images
Authors: Yuan Hong Xu , Liao Zhiwu , Wang Rui Xin , Dong Xinceng , Liu Tao , Long Wu Dan , Wei Qing Jin , Xu Ya Jie , Yu Yong , Chen Peng , Hou Rong
Published: February 2022

Deep neural networks (DNNs) with long-range dependence (LRD) have attracted more and more attention recently. However, LRD of DNNs is proposed from the view on gradient disappearance in training, which lacks theory analysis. In order to prove LRD of foggy images, the Hurst parameters of over 1,000 foggy images in SOTS are computed and discussed. Then, the Residual Dense Block Group (RDBG), which has additional long skips among two Residual Dense Blocks to fit LRD of foggy images, is proposed. The Residual Dense Block Group can significantly improve the details of dehazing image in dense fog and reduce the artifacts of dehazing image.
Analysis of Evolution of Coupled Lorentz Resonances and Their Sensing Properties in Terahertz Metamaterials
Authors: Jiang Nan , Zhang Ziye , Liang Wanlin , Deng Yuwang , Zhang Pujing , Zhang Cunlin , Zhou Qingli
Published: February 2022

Combined with experimental and simulated results, the resonances and metamaterial-induced transparency have been theoretically investigated using the Lorentz oscillator model for terahertz metamaterials with unequal-length bar structures. The bar spacing has an impact on the spectral evolution, implying that the coupling between metal bars varies correspondingly in one unit cell and the adjacent cells. Different from the evidence that the strongest coupling occurs in double bar structures when the bar spacing is uniform in the entire sample, the coupling in 3 bar structures is more complicated due to the weakened coupling with the middle bar and increased coupling between the other 2 bars by further increasing the bar spacing. The dependence of calculated transmission spectra on the damping rate and coupling coefficient is demonstrated, showing that the fitting parameters could control and tune the resonant dips, the transparency peaks, and even the quality factors of the spectra regularly. Furthermore, the sensing properties have been investigated by simulating the spectral evolution with the overlayers of different refractive indices to optimize the sensing parameters. Our obtained results could advance the understanding of resonance coupling and offer the possibility to further study the modulation and biosensing in the coupled terahertz devices.
Cardiovascular Reactivity to a Novel Stressor: Differences on Susceptible and Resilient Rats to Social Defeat Stress
Authors: Morais-Silva Gessynger , Gomes-de-Souza Lucas , Costa-Ferreira Willian , Pavan Jacqueline C. , Crestani Carlos C. , Marin Marcelo T.
Published: February 2022

Prolonged and heightened responses to stress are known factors that influence the development of mood disorders and cardiovascular diseases. Moreover, the coping strategies related to the experience of adverse events, i.e., resilience or the susceptibility to stress, are determinants for the individual risk of developing such diseases. Susceptible rats to the social defeat stress (SDS), identified by the social interaction test (SIT), show behavioral and cardiovascular alterations after SDS exposure that are not found in resilient rats. However, it is not elucidated yet how the cardiovascular system of susceptible and resilient phenotypes responds to a new stressor after SDS exposure. Thus, using the SDS exposure followed by the SIT, we evaluated heart rate, blood pressure (BP), tail skin temperature, and circulating corticosterone responses to an acute session of restraint stress in susceptible and resilient rats to SDS. Susceptible rats showed resting tachycardia and exaggerated BP response to restraint stress, while resilient rats did not present such alterations. In contrast, both phenotypes showed increased plasma corticosterone and a drop in tail skin temperature to restraint stress, which was similar to that observed in control animals. Our results revealed an increased cardiovascular reactivity in response to a new stressful stimulus in susceptible rats, which might be related to a greater risk for the development of cardiovascular diseases.
Rapid Adjustments in Thermal Tolerance and the Metabolome to Daily Environmental Changes – A Field Study on the Arctic Seed Bug Nysius groenlandicus
Authors: Noer Natasja Krog , Sørensen Mathias Hamann , Colinet Hervé , Renault David , Bahrndorff Simon , Kristensen Torsten Nygaard
Published: February 2022

Laboratory investigations on terrestrial model-species, typically of temperate origin, have demonstrated that terrestrial ectotherms can cope with daily temperature variations through rapid hardening responses. However, few studies have investigated this ability and its physiological basis in the field. Especially in polar regions, where the temporal and spatial temperature variations can be extreme, are hardening responses expected to be important. Here, we examined diurnal adjustments in heat and cold tolerance in the Greenlandic seed bug Nysius groenlandicus by collecting individuals for thermal assessment at different time points within and across days. We found a significant correlation between observed heat or cold tolerance and the ambient microhabitat temperatures at the time of capture, indicating that N. groenlandicus continuously and within short time-windows respond physiologically to thermal changes and/or other environmental variables in their microhabitats. Secondly, we assessed underlying metabolomic fingerprints using GC-MS metabolomics in a subset of individuals collected during days with either low or high temperature variation. Concentrations of metabolites, including sugars, polyols, and free amino acids varied significantly with time of collection. For instance, we detected elevated sugar levels in animals caught at the lowest daily field temperatures. Polyol concentrations were lower in individuals collected in the morning and evening and higher at midday and afternoon, possibly reflecting changes in temperature. Additionally, changes in concentrations of metabolites associated with energetic metabolism were observed across collection times. Our findings suggest that in these extreme polar environments hardening responses are marked and likely play a crucial role for coping with microhabitat temperature variation on a daily scale, and that metabolite levels are actively altered on a daily basis.
The Adoption of QR Code Mobile Payment Technology During COVID-19: A Social Learning Perspective
Authors: Tu Ming , Wu Lei , Wan Hua , Ding Zhoujin , Guo Zizheng , Chen Jiayi
Published: February 2022

The increasing number of quick response (QR) code mobile payment users heralds the coming of a cashless society. However, the extent to which the coronavirus disease 2019 (COVID-19) pandemic accelerated the adoption of QR code mobile payment has not been sufficiently researched. Based on social learning theory, this study models how external interaction with the environment has affected the internal appraisal and behavioral intention to adopt QR code mobile payment during COVID-19. Empirical results from 248 respondents revealed that perceived severity and social influence positively affected the perception of utilitarian and health benefits of respondents, which in turn influenced the behavioral intention to use the QR code mobile payment. The theoretical contribution and managerial implications of this study are also discussed.
The Tendency of Terrorist Organizations to Explosive Attacks: An Institutional Theory Perspective
Authors: Luo Lanjun , Qi Chao
Published: February 2022

Focusing on the tendency of terrorist organizations to explosive attack, this article applied the institutional theory as the basis to explain the inherent logic of attack type similarity from the perspective of mimetic, coercive, and normative isomorphism. Subsequently, the study conducted an empirical analysis of the data onto 1825 terrorist organizations recorded in the Global Terrorism Database with the logistic regression method. The results show that: (1) Terrorist organizations will learn from pre-existing terrorist organizations' experiences, and mimetic isomorphism will promote explosive tendency; (2) Due to the normative isomorphism effect, terrorist groups' tendency to explosive attacks is weakened by their increased duration; (3) If terrorist organizations are hostile to a strong government, coercive isomorphism positively moderates the negative effects of increasing duration. The study suggests that counter-terrorism approaches such as destroying the learnable experience of attacks, addressing the root causes of terrorism, and maintaining a strong government may be helpful in stopping increasing terrorist activities, which is essential for reducing terrorist organizations' vivosphere, blocking the inter-flow and imitation between terrorist organizations, and ultimately interrupting the terrorist propagation chain.
Experience of the Absence of the Journey to Sessions in Clients' Narratives About Online Psychotherapy
Authors: Galasiński Dariusz , Ziółkowska Justyna , Witkowicz Magdalena
Published: February 2022

Background

Remotely provided psychotherapy due to the COVID-19 pandemic became common. One of the most significant changes related to providing online psychotherapy services is that clients no longer travel to their sessions.

Aims

In the article we are interested in the narrated experience of the absence of journey to psychotherapy sessions. We study clients' stories of past journeys and how their absence, resulting from the change of the mode of therapy provision, is coped with and replaced by other activities in their narratives.

Methods

The study takes a constructionist approach to discourse and focuses on the lexico-grammatical form of the notes. The data come from 12 semi-structured interviews with people who declared attending remote psychotherapy sessions after the national lockdown had been introduced.

Results

In the collected data, the physical journey is constructed not only as travel time, solitude which can be used for reflection, but, importantly, as an active process which ends with a resolution. In contrast, in narratives of the time before an online session, constructions of unfettered agents are replaced with those of people whose actions are hedged and qualified.

Conclusion

We argue that in the informants' narratives the journey to psychotherapy is meaningful and is part of the therapeutic process. We propose that it is a time of passing between two states—one before therapy and one in session. The journey therefore is experienced as a process of change, and not only a process of traveling.
Impact of Face-Recognition-Based Access Control System on College Students’ Sense of School Identity and Belonging During COVID-19 Pandemic
Authors: Wang Qiang , Hou Lan , Hong Jon-Chao , Yang Xiantong , Zhang Mengmeng
Published: February 2022

In the context of coronavirus pandemic (COVID-19), the face-recognition-based access control system (FACS) has been intensively adopted to protect students’ and teachers’ health and safety in school. However, the impact of FACS, as a new technology, on students’ attitude toward accepting FACS has remained unknown from the psychological halo effect. Drawn on “halo effect” theory where psychological effects affect the sense of social identity and belonging, the present study explored college students’ sense of school identity and belonging in using FACS during COVID-19 based on the technology acceptance model (TAM). Data collected from 391 college students was analyzed using SEM to verify the relationship among perceived usefulness (PU), perceived ease of use (PEU), intention to use (IU), school identity, and school belonging. The results show that PU and PEU can positively predict IU, and consequentially can positively predict school identity and school belonging. Our study expands the application of halo effect theory to study FACS acceptance based on TAM, and provides strong evidence to support the effect of school FACS during the pandemic. The findings of this study also suggest that FACS acceptance can enhance students’ sense of school identity and belonging.
Psychological Distancing Usage Uniquely Predicts Reduced Perceived Stress During the COVID-19 Pandemic
Authors: Dicker Eva E. , Jones Jenna S. , Denny Bryan T.
Published: February 2022

Social distancing during the COVID-19 pandemic has presented millions of people with extraordinary challenges that are associated with significant amounts of stress. Emotion regulation is crucial during this crisis as people seek to mitigate the stress and uncertainty of the present moment. In this study, we surveyed a nationally representative sample of 297 adults from the United States on their levels of perceived stress related to the COVID-19 pandemic as well as their level of engagement of different emotion regulation strategies during the pandemic. We performed multiple linear regression analyses to assess which regulation strategies were associated with individual differences in perceived stress. Among all emotion regulation strategies, psychological distancing, which involves thinking about stressful circumstances in an objective, impartial way, was uniquely associated with reductions in perceived stress due to COVID-19 across individuals. This effect was not moderated by age, gender, socioeconomic status, race/ethnicity, or trait-related difficulty in regulating emotion. Conversely, situation modification was associated with significantly greater perceived stress overall. These results suggest the broad applicability and utility of psychological distancing during pandemic-related social distancing as part of an adaptive emotion regulation toolkit and motivate the investigation of interventions involving psychological distancing in this context.
Prostate Cancer Incidence and Mortality: Global Status and Temporal Trends in 89 Countries From 2000 to 2019
Authors: Wang Le , Lu Bin , He Mengjie , Wang Youqing , Wang Zongping , Du Lingbin
Published: February 2022

Aims

To evaluate current status of prostate cancer incidence and mortality worldwide, and compare the global trends of incidence and mortality in the past two decades and in the most recent period.

Methods

Data on the incidence and mortality of prostate cancer for 174 countries in 2020 were obtained from the GLOBOCAN 2020 database, and associations with the human development index (HDI) were evaluated. Data for trend analyses in 89 countries from 2000 to 2019 were retrieved from the Global Burden of Disease 2019 platform. Age standardized incidence rate (ASIR) and mortality rate (ASMR) were calculated by using the Segi's population. The average annual percent changes (AAPC) of ASIRs and ASMRs were evaluated by joinpoint regression analysis.

Results

A total of 1 414 259 new cases of prostate cancer and 375 304 related deaths were reported in 2020 globally. HDI was positively correlated with ASIRs (P < 0.001) and negatively correlated with ASMRs (P < 0.001). In the past two decades, ASIRs have been increasing in 65 countries, stable in 15 countries and decreasing in 9 countries, and ASMRs have been increasing in 19 countries, stable in 25 countries and decreasing in 45 countries, respectively. In the most recent period, 44 countries have increasing ASIRs, and 32 countries have decreasing ASMRs, respectively. For instance, in the United States of America, the AAPC of ASIRs significantly decreased by 0.62% and ASMRs significantly decreased by 1.22% from 2000 to 2019, while the AAPC from 2015 to 2019 significantly increased by 0.49% for ASIRs and significantly increased by 0.48% for ASMRs.

Conclusion

The magnitude of increasing incidence and decreasing mortality of prostate cancer is attenuated in the recent period. Further study is needed to analyze the absolute effect of risk factors, PSA screening and treatment.
Inference-Optimized AI and High Performance Computing for Gravitational Wave Detection at Scale
Authors: Chaturvedi Pranshu , Khan Asad , Tian Minyang , Huerta E. A. , Zheng Huihuo
Published: February 2022

We introduce an ensemble of artificial intelligence models for gravitational wave detection that we trained in the Summit supercomputer using 32 nodes, equivalent to 192 NVIDIA V100 GPUs, within 2 h. Once fully trained, we optimized these models for accelerated inference using NVIDIA TensorRT. We deployed our inference-optimized AI ensemble in the ThetaGPU supercomputer at Argonne Leadership Computer Facility to conduct distributed inference. Using the entire ThetaGPU supercomputer, consisting of 20 nodes each of which has 8 NVIDIA A100 Tensor Core GPUs and 2 AMD Rome CPUs, our NVIDIA TensorRT-optimized AI ensemble processed an entire month of advanced LIGO data (including Hanford and Livingston data streams) within 50 s. Our inference-optimized AI ensemble retains the same sensitivity of traditional AI models, namely, it identifies all known binary black hole mergers previously identified in this advanced LIGO dataset and reports no misclassifications, while also providing a 3X inference speedup compared to traditional artificial intelligence models. We used time slides to quantify the performance of our AI ensemble to process up to 5 years worth of advanced LIGO data. In this synthetically enhanced dataset, our AI ensemble reports an average of one misclassification for every month of searched advanced LIGO data. We also present the receiver operating characteristic curve of our AI ensemble using this 5 year long advanced LIGO dataset. This approach provides the required tools to conduct accelerated, AI-driven gravitational wave detection at scale.
Particle Size Distribution of Organic Complete Diets for Laying Hens during Feed Offering
Authors: Nunnenkamp Dietrich , Bierschenk Eyleen , Westendarp Heiner , Wolf Petra
Published: February 2022

Complete diets for laying hens are usually offered in meal form. This form initially promotes the laying hens’ natural feed intake behavior and allows them to satisfy their pecking behavior. At the same time, it can also cause difficulties, because it consists of different particles and is not a homogeneous unit. A homogeneous mixture is essential to ensure that each laying hen in the flock can meet its nutritional needs. If feed exhibits a wide particle size distribution, this can promote feed segregation during transport and selective feed intake behavior of laying hens. These two processes sometimes lead to significant differences between the composition of the feed produced and the composition of the feed that is finally ingested by the laying hens. Multi-stage sampling can be used to investigate progressing differences in feed composition. In this study, samples of different complete diets for laying hens (n = 76) were collected from ten organic farms in Germany to examine their particle size distributions (dry sieve analysis). Samples were taken at four different locations (V1 = loading, V2 = silo, V3 = at the beginning of the feed chain, V4 = at the end of the feed chain) in each farm. There was a tendency for V1 and V2 to be characterized by high proportions of particles between 1400 and 3150 µm (V1 = 61.2%, V2 = 43.5%). V3 and V4 consisted mainly of particles of size 500–800 µm and 200–400 µm, respectively. The lowest proportions across all variants were in the range above 3150 µm (V1 = 2.20%, V2 = 1.30%, V3 = 1.00%, V4 = 0.400%) and between 400 and 500 µm (V1 = 2.50%, V2 = 4.50%, V3 = 5.70%, V4 = 6.60%). The mean value comparison of the proportions of sieve mesh sizes from 200 to 1000 µm resulted in: V1 < V2 < V3 < V4; and of sieve mesh sizes between 1400 and 2000 µm in: V1 > V2 > V3 > V4. This observation can be explained by segregation of the feed during transport and a selective feeding behavior of the laying hens. However, trends were discontinuous and varied between the farms. Deviations from the guideline values were found in particular for particle sizes in the range of 1000 to 1400 µm.
Inhibiting Copper Amine Oxidase Using L-Aminoguanidine Induces Cultivar and Age-Dependent Alterations of Polyamine Catabolism in Tomato Seedlings
Authors: Szepesi Ágnes , Bakacsy László , Kovács Henrietta , Szilágyi Árpád , Köhler Zoltán Márton
Published: February 2022

Many effects of polyamines (PAs) are well known in plant developmental processes; however, the significance of their catabolism is not well understood. Copper amine oxidase (CuAO) is involved in the degradation of diamine putrescine (Put). The genotype dependence and time-dependent effects of this enzyme are rarely examined, so this study aims to discover the role of CuAO in tomato genotypes in different stages of seedling development. Exogenously applied L-aminoguanidine (AG), a CuAO inhibitor, was used to decrease the activity of CuAOs. Based on our results, it can be concluded that there is a genotype dependence of Put degradation, and AG treatment caused a long-term shift of PA catabolism by changing the activities of polyamine oxidase (PAO), catalyzing the degradation of higher PAs. Our results demonstrate that the modification of PA catabolism could have long-term results in polyamine metabolism in different tomato genotypes.
Effect of Micro- and Macro-Mechanical Characteristics of Jujube Bark on Jujube Girdling Quality
Authors: Ran Junhui , Hu Can , Zhang Fengkui , Wang Xufeng , Li Ping
Published: February 2022

Jujube girdling is an important method to improve the yield and quality of jujube fruit. However, girdling usually causes the tearing of jujube bark, resulting in the slow healing and even death of jujube trees. These problems directly affect the economic benefits of jujube planting. In this paper, in order to reveal the tearing mechanism of jujube bark caused by girdling, and provide the basic mechanical parameters of jujube bark for the research and development of automatic girdling equipment, the structure and mechanical characteristics of jujube bark were studied through theory and experimental methods. The results of microscopic observation showed that jujube bark is a biological composite material mainly composed of the phloem, periderm and epidermis. Furthermore, a mathematical model-based analysis of the growth stress of jujube bark showed that growth stress can be regarded as a biaxial stress state, which can promote the longitudinal tearing of jujube bark during girdling. The tensile test results of jujube bark showed that jujube bark belongs to the category of anisotropic and biologic material. Its longitudinal and transverse mechanical characteristics are significantly different. The maximum longitudinal tensile load was in the range of 105.9~293 N, the longitudinal tensile strength was 16.3 MPa and the elastic modulus was 255.6 MPa. The average transverse tensile load was only 27.9% of the longitudinal tensile load. The transverse tensile strength was 3.5 Mpa and its elastic modulus was 724.14 MPa. The transverse cutting test of jujube bark showed that the average cutting force was 118.2 N and the cutting strength was 9.8 MPa. The results of this study showed that both the growth stress and the anisotropic natural polymer of jujube bark have adverse effects on girdling. Subsequently, issues relating to the selection of appropriate girdling tools and the matters needing attention in the process of the girdling operation were proposed, so as to guide the correct application of girdling technology. In addition, some suggestions on the research and development of girdling tools in the future are put forward.
Development of Desirable Behaviors in Dog-Assisted Interventions
Authors: Acebes Félix , Pellitero Juan Luis , Muñiz-Diez Clara , Loy Ignacio
Published: February 2022

Dog-assisted interventions (DAI) are those that include specially trained dogs in human health services. Often, the training methods employed to train animals for DAI are transmitted between trainers, so the latest scientific research on dog learning and cognition is not always taken into account. The present work aims to evaluate the impact that the main theories on the evolution of the dog have had both in promoting different training methods and in the relevance of behavior in the evolution of the skills of actual dogs. Then, an integrative method for the training of dogs is presented. This method takes into account the research on dog learning mechanisms and cognition processes, and effectively promotes the development of desirable behaviors for DAI during the dog’s ontogeny.
Influences of Dog Attachment and Dog Walking on Reducing Loneliness during the COVID-19 Pandemic in Korea
Authors: Lee Hyung-Sook , Song Jin-Gyeoung , Lee Jeong-Yeon
Published: February 2022

The COVID-19 pandemic has changed people’s lives and increased their vulnerability to physical and mental health hazards. While Korea has avoided nationwide lockdown measures since the COVID-19 outbreak, the prolonged restrictions and social isolation measures have resulted in detrimental psychological effects, such as increased anxiety, boredom, and loneliness. The present study investigated dog attachment and changes in dog walking during the COVID-19 pandemic and the effects of dog attachment and dog walking on the loneliness of Korean dog owners. An online, cross-sectional survey was conducted in the fall of 2021 in which 249 dog owners responded to questionnaires that asked questions about dog attachment, their perception of dog walking, and their feelings of loneliness during the COVID-19 pandemic. Most dog owners responded that they spent more time with their dogs and developed a stronger bond with them during the pandemic. Additionally, respondents stated that they walked their dogs more often than they did before COVID-19 and that their dogs aided in reducing loneliness. We found that dog walking directly affected attachment and indirectly influenced the loneliness of dog owners. Further research is required to determine how dog walking impacts positive psychological effects and promote dog walking.
A Deep Attention Model for Action Recognition from Skeleton Data
Authors: Gao Yanbo , Li Chuankun , Li Shuai , Cai Xun , Ye Mao , Yuan Hui
Published: February 2022

This paper presents a new IndRNN-based deep attention model, termed DA-IndRNN, for skeleton-based action recognition to effectively model the fact that different joints are usually of different degrees of importance to different action categories. The model consists of (a) a deep IndRNN as the main classification network to overcome the limitation of a shallow RNN network in order to obtain deeper and longer features, and (b) a deep attention network with multiple fully connected layers to estimate reliable attention weights. To train the DA-IndRNN, a new triplet loss function is proposed to guide the learning of the attention among different action categories. Specifically, this triplet loss enforces intra-class attention distances to be smaller than inter-class attention distances and at the same time to allow multiple attention weight patterns to exist for the same class. The proposed DA-IndRNN can be trained end-to-end. Experiments on the widely used datasets, including the NTU RGB + D dataset and UOW Large-Scale Combined (LSC) Dataset, have demonstrated that the proposed method can achieve better and stable performance than the state-of-the-art attention models.
Effects of Grafting Degree on the Physicochemical Properties of Egg White Protein-Sodium Carboxymethylcellulose Conjugates and Their Aerogels
Authors: Tang Shuaishuai , Jiang Yan , Tang Tingting , Du Huaying , Tu Yonggang , Xu Mingsheng
Published: February 2022

To improve the mechanical strength and oil-loading performances of egg white protein (EWP) aerogel, the effects of different grafting degrees on the modification of EWP by sodium carboxymethylcellulose (CMC-Na) were investigated. After different dry-heat treatment durations (0, 12, 24, 36, and 48 h), the EWP/CMC-Na conjugates with different grafting degrees (noted as EC0, EC12, EC24, EC36, and EC48, respectively) were obtained. Subsequently, the physicochemical properties of the conjugates, as well as the microstructure, mechanical properties, pore parameters, emulsification properties and oil-carrying properties of the conjugated aerogels, were characterized. The results showed that EC12 (with a grafting degree of 8.35%) aerogel possessed a uniform structure, the largest specific surface area, and the best emulsification performance. This facilitated a more robust aerogel (2.05 MPa) with nearly three times the mechanical strength of EWP aerogel. Moreover, this had a positive influence on the efficient loading and stable retention of oil. EC12 aerogel thus achieved an oil absorption capacity of 5.46 g/g aerogel and an oil holding capacity of 31.95%, and both values were nearly 1.7 times higher than those of EWP aerogel. In general, the EWP-based aerogel with a grafting degree of 8.35% had the best mechanical and oil-loading properties.
Short-Term Treatment of Metformin and Glipizide on Oxidative Stress, Lipid Profile and Renal Function in a Rat Model with Diabetes Mellitus
Authors: Abdel-Moneim Abdel-Moneim Hafez , Lutfi Mohamed Faisal , Alsharidah Ashwag Saleh , Shaker Gehan , Faisal Waleed , Abdellatif Ahmed A. H. , Rugaie Osamah Al , Mohany Khalid M. , Eid Safaa Yehia , El-Readi Mahmoud Zaki , Alsharidah Mansour
Published: February 2022

Background: Oxidative stress, lipid profile and renal functions are well-known conventional risk factors for diabetes mellitus (DM). Metformin and gliclazide are popularly used monotherapy drugs for the treatment of DM. Aims: This study aims to assess the short-term treatment of single and dual therapy of glipizide/metformin on oxidative stress, glycemic control, serum lipid profiles and renal function in diabetic rats. Methods: DM was induced in rats with streptozotocin (STZ), then five different treatments were applied, including group I (untreated healthy control), group II (diabetic and untreated), group III (diabetic and treated with metformin), group IVI (diabetic and treated with glipizide) and group V (diabetic and treated with a combination of metformin and glipizide. Lipid peroxidation (LPO), nitric oxide (NO), total antioxidant capacity (TAC), fasting blood glucose (FBG), glycated hemoglobin (HbA1c), total cholesterol, triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL), creatinine and urea were measured. Results: Compared to the untreated DM group, FBG and HbA1c were significantly reduced in the DM groups (p < 0.01) treated with metformin (159.7 mg/dL & 6.7%), glipizide (184.3 mg/dL & 7.3%) and dual therapy (118 mg/dL & 5.2%), respectively. Treatment with dual therapy and metformin significantly decreased LPO and NO levels but increased TAC in diabetic rats more than glipizide compared to untreated diabetic rats. Furthermore, metformin (19.8 mg/dL, p < 0.001), glipizide (22.7 mg/dL, p < 0.001), and dual therapy (25.7 mg/dL, p < 0.001) significantly decreased urea levels in the treated rats compared to untreated DM rats (32.2 mg/dL). Both drugs and their combination exhibited a substantial effect on total cholesterol, HDL, LDL and atherogenic index. Conclusions: These results suggest that the therapeutic benefits of metformin and glipizide are complementary. Metformin exhibited superior performance in improving glycemic control and decreasing oxidative stress, while glipizide was more effective against dyslipidemia. These findings could be helpful for the treatment of future vascular patients, antilipidemic medicines and antioxidant therapy to improve the quality of life.
Machine Learning for Biomedical Application
Authors: Strzelecki Michał , Badura Pawel
Published: February 2022

The tremendous development of technology also affects medical science, including imaging diagnostics [...]
Polarization Sensitive Imaging with Qubits
Authors: Sukharenko Vitaly , Dorsinville Roger
Published: February 2022

We compare reconstructed quantum state images of a birefringent sample using direct quantum state tomography and inverse numerical optimization technique. Qubits are used to characterize birefringence in a flat transparent plastic sample by means of polarization sensitive measurement using density matrices of two-level quantum entangled photons. Pairs of entangled photons are generated in a type-II nonlinear crystal. About half of the generated photons interact with a birefringent sample, and coincidence counts are recorded. Coincidence rates of entangled photons are measured for a set of sixteen polarization states. Tomographic and inverse numerical techniques are used to reconstruct the density matrix, the degree of entanglement, and concurrence for each pixel of the investigated sample. An inverse numerical optimization technique is used to obtain a density matrix from measured coincidence counts with the maximum probability. Presented results highlight the experimental noise reduction, greater density matrix estimation, and overall image enhancement. The outcome of the entanglement distillation through projective measurements is a superposition of Bell states with different amplitudes. These changes are used to characterize the birefringence of a 3M tape. Well-defined concurrence and entanglement images of the birefringence are presented. Our results show that inverse numerical techniques improve overall image quality and detail resolution. The technique described in this work has many potential applications.
Multiparametric Sensor Node for Environmental Monitoring Based on Energy Harvesting
Authors: Crescini Damiano , Touati Farid , Galli Alessio
Published: February 2022

The heterogeneity and levels of chemicals released into the environment have dramatically grown in the last few years. Therefore, new low-cost tools are increasingly required to monitor pollution and follow its trends over time. Recent approaches in electronics and wireless communications permit the expansion of low-power, low-cost, and multiparametric sensor nodes that are limited in size and communicate untethered in small distances. For such a monitoring system to be ultimately feasible, a suitable power source for these nodes must be found. The present research falls within the frame of this global effort. The study sits within the context discussed above with the particular aim of developing groundbreaking technology-based solutions by means of efficient environmentally powered wireless smart sensors. This paper presents a multiparametric sensor node for indoor/outdoor air quality monitoring, able to work without battery and human intervention, harvesting energy from the surrounding environment for perpetual operation. The complete system design of the sensor and experimental results are reported. The evaluation of the energy-harvesting blocks with a budget allocation of the power consumption is also discussed.
Spatial Evolution of Energetic Electrons Affecting the Upper Atmosphere during the Last Two Solar Cycles
Authors: Dmitriev Alexei V. , Suvorova Alla V. , Ghosh Sayantan , Golubkov Gennady V. , Golubkov Maxim G.
Published: February 2022

Future commercial, scientific, and other satellite missions require low-Earth-orbit (LEO) altitudes of 300–400 km for long-term successful space operations. The Earth’s radiation belt (ERB) is an inevitable obstacle for manned and other space missions. Precipitation of >30 keV energetic electrons from the ERB is one of the sources of ionization in LEO, space vehicles, in the ionosphere, and in the upper atmosphere. We show, in this work, that the area of electron precipitation from the outer ERB shifts equator-wards to Siberia. We further show a substantive decrease in the intensity of energetic electrons in the area of the South Atlantic Anomaly (SAA) from the 23rd to the 24th solar cycles. These results can be attributed to, and explained by, variations in geomagnetic activity, with a noticeable change in the configuration of the Earth’s magnetic field during the 24th solar cycle. The diminishing SAA area and electron fluxes should allow elevation of the International Space Station to higher altitudes, thereby making these altitudes accessible to relevant space missions.