bluuebunny/crossref_metadata_2025 huggingface dataset:
CRISPR/Cas13a-based rapid detection method for porcine deltacoronavirus
Authors: Luo Ran , Cheng Zhimeng , Wang Haoyu , Yang Qiyue , Zeng Yongping , Yang Yijun , Chen Yuankun , Li Wenting , Liu Xiao
Published: July 2024

Background

Porcine deltacoronavirus (PDCoV) is a newly discovered porcine intestinal pathogenic coronavirus with a single-stranded positive-sense RNA genome and an envelope. PDCoV infects pigs of different ages and causes acute diarrhea and vomiting in newborn piglets. In severe cases, infection leads to dehydration, exhaustion, and death in sick piglets, entailing great economic losses on pig farms. The clinical symptoms of PDCoV infection are very similar to those of other porcine enteroviruses. Although it is difficult to distinguish these viral infections without testing, monitoring PDCoV is very important because it can spread in populations. The most commonly used methods for the detection of PDCoV is qPCR, which is time-consuming and require skilled personnel and equipment. Many farms cannot meet the conditions required for detection. Therefore, it is necessary to establish a faster and more convenient method for detecting PDCoV.

Aims

To establish a rapid and convenient detection method for PDCoV by combining RPA (Recombinase Polymerase Isothermal Amplification) with CRISPR/Cas13a.

Methods

Specific RPA primers and crRNA for PDCoV were designed, and the nucleic acids in the samples were amplified with RPA. Fluorescent CRISPR/Cas13a detection was performed. We evaluated the sensitivity and specificity of the RPA–CRISPR/Cas13a assay using qPCR as the control method.

Results

CRISPR/Cas13a-assisted detection was completed within 90 min. The minimum detection limit of PDCoV was 5.7 × 101 copies/μL. A specificity analysis showed that the assay did not cross-react with three other porcine enteroviruses.

Conclusion

The RPA–CRISPR/Cas13a method has the advantages of high sensitivity, strong specificity, fast response, and readily accessible results, and can be used for the detection of PDCoV.
A case of chorea-acanthocytosis with significant improvement of symptoms at one year with deep brain stimulation: case report and literature review
Authors: Xu Yan , Yu Jiabin , Gao Yimeng , Su Qiaozhen , Xie Haitao , Liang Hongfeng , Zheng Chunye
Published: July 2024

Chorea-acanthocytosis (ChAc) is a rare, neurodegenerative disorder caused by mutations in the VPS13A gene. In this article, we report on a 32-year-old man diagnosed with ChAc, with involuntary movements of the mouth and trunk, drooling of the mouth, slurred speech, and abnormal vocalizations as the main clinical manifestations. Three weeks after implantation of globus pallidus internal (GPi)-deep brain stimulation (DBS), the patient’s symptoms improved significantly. For example, articulation is clear, involuntary trunk movements and salivation have largely disappeared, and abnormal vocalizations have been significantly reduced. After 1 year of follow-up, the improvement in involuntary movement symptoms is essentially the same as before. As far as we know, we are the first to report the relief of involuntary vocalizations in a patient with GPi-DBS treatment, and that salivation and involuntary trunk movements have almost disappeared, and all other symptoms are significantly relieved, which is rare in previous cases. All of the above proves that the treatment of our case with DBS was very successful and that longer term follow-up is critical. We also hope that our case will provide new references and therapeutic ideas for the future treatment of patients with ChAc.
Migrainous vertigo impairs adaptive learning as a function of uncertainty
Authors: Sharif Mishaal , Rea Oliver , Burling Rose , Ellul Miraval Mel , Patel Rakesh , Saman Yougan , Rea Peter , Yoon Ha-Jun , Kheradmand Amir , Arshad Qadeer
Published: July 2024

Objective

In this study, we examined whether vestibular migraine, as a source of increased perceptual uncertainty due to the associated dizziness, interferes with adaptive learning.

Methods

The IOWA gambling task (IGT) was used to assess adaptive learning in both healthy controls and patients with migraine-related dizziness. Participants were presented with four decks of cards (A, B, C, and D) and requested to select a card over 100 trials. Participants received a monetary reward or a penalty with equal probability when they selected a card. Card decks A and B (high-risk decks) involved high rewards (win £100) and high penalties (lose £250), whereas C and D (low-risk decks; favorable reward-to-punishment ratio) involved lower rewards (win £50) and penalties (lose £50). Task success required participants to decide (i.e., adaptively learn) through the feedback they received that C and D were the advantageous decks.

Results

The study revealed that patients with vestibular migraine selected more high-risk cards than the control group. Chronic vestibular migraine patients showed delayed improvement in task performance than those with acute presentation. Only in acute vestibular migraine patients, we observed that impaired learning positively correlated with measures of dizzy symptoms.

Conclusion

The findings of this study have clinical implications for how vestibular migraine can affect behavioural adaption in patients, either directly through altered perception or indirectly by impacting cognitive processes that can result in maladaptive behavior.
A randomized, double-blind, placebo-controlled clinical study to evaluate the efficacy and safety of Weizmannia coagulans BC99 in the treatment of chronic constipation in adults
Authors: Wu Ying , Bai Zhouya , Jin Yuehong , Zhu Hong , Dong Yao , Gu Shaobin , Jin Ying
Published: July 2024

Introduction

Weizmannia coagulans has emerged as a promising candidate for the management of gastrointestinal ailments. The novel strain of Weizmannia coagulans, Weizmannia coagulans BC99 (BC99), displays robust pathogen-inhibiting capabilities, susceptibility to various antibiotics, and a high level of biosafety. Nevertheless, additional research is necessary to fully understand its effectiveness in managing chronic constipation.

Methods

This study investigates the role of BC99 in alleviating chronic constipation in a double-blind, placebo-controlled, randomized trial, and participants were divided into BC99 (2 billion CFU/d) or placebo (maltodextrin) groups for a 4-week period.

Results and discussion

Results showed that significant improvements were noted in the BC99 group, with an increase in complete spontaneous bowel movements (CSBM) after 4-week treatment compared to the placebo (p = 0.002). The BC99 group also showed significantly lower Quality of Life (PAC-QOL) scores and reduced Constipation Symptoms (PAC-SYM) scores after 4 weeks of treatment (p < 0.001), indicating symptomatic relief. Notably, BC99 effectively modulated key gut microbiota such as Bifidobacterium and Ruminococcus, linked to crucial metabolic pathways like glutathione metabolism. In all, BC99 is confirmed to be an effective and safe therapeutic option for the relief of adult chronic constipation, enhancing gut microbiota balance and influencing critical metabolic pathways.

Clinical trial registration

ChiCTR2200065493.
The role of coffee and potential mediators in subclinical atherosclerosis: insights from Mendelian randomization study
Authors: Yang Qiwen , Yuan Yue , Lyu Diyang , Zhuang Rui , Xue Donghua , Niu Chaofeng , Ma Liyong , Zhang Lijing
Published: July 2024

Background and aims

Coffee contains many bioactive compounds, and its inconsistent association with subclinical atherosclerosis has been reported in observational studies. In this Mendelian randomization study, we investigated whether genetically predicted coffee consumption is associated with subclinical atherosclerosis, as well as the role of potential mediators.

Methods

We first conducted a two-sample Mendelian randomization analysis to examine the causal effect of coffee and its subtypes on subclinical atherosclerosis inferred from coronary artery calcification (CAC). Next, the significant results were validated using another independent dataset. Two-step Mendelian randomization analyses were utilized to evaluate the causal pathway from coffee to subclinical atherosclerosis through potential mediators, including blood pressure, blood lipids, body mass index, and glycated hemoglobin. Mendelian randomization analyses were performed using the multiplicative random effects inverse-variance weighted method as the main approach, followed by a series of complementary methods and sensitivity analyses.

Results

Coffee, filtered coffee, and instant coffee were associated with the risk of CAC (β = 0.79, 95% CI: 0.12 to 1.47, p = 0.022; β = 0.66, 95% CI: 0.17 to 1.15, p = 0.008; β = 0.66, 95% CI: 0.20 to 1.13, p = 0.005; respectively). While no significant causal relationship was found between decaffeinated coffee and CAC (β = −1.32, 95% CI: −2.67 to 0.04, p = 0.056). The association between coffee and CAC was validated in the replication analysis (β = 0.27, 95% CI: 0.07 to 0.48, p = 0.009). Body mass index mediated 39.98% of the effect of coffee on CAC (95% CI: 9.78 to 70.19%, p = 0.009), and 5.79% of the effect of instant coffee on CAC (95% CI: 0.54 to 11.04%, p = 0.030).

Conclusion

Our study suggests that coffee other than decaffeinated coffee increases the risk of subclinical atherosclerosis inferred from CAC. Body mass index mediated 39.98 and 5.79% of the causal effects of coffee and instant coffee on CAC, respectively. Coffee should be consumed with caution, especially in individuals with established cardiovascular risk factors, and decaffeinated coffee appears to be a safer choice.
A diet-wide Mendelian randomization analysis: causal effects of dietary habits on type 2 diabetes
Authors: Xiao Rui , Dong Li , Xie Bo , Liu Beizhong
Published: July 2024

Background

Traditional clinical studies have indicated a link between certain food intakes and type 2 diabetes (T2D), but the causal relationships between different dietary habits and T2D remain unknown. Using Mendelian randomization (MR) approaches, we investigated the potential causal association between dietary habits and T2D risk.

Methods

We collected publicly available genome-wide association studies’ summary statistics for 18 dietary habits from the UK Biobank and T2D data from the DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) consortium. We applied the inverse variance weighted (IVW) method, supplemented with the MR-Egger method, weighted median method (WMM), simple method, weighted mode, MR-Egger regression, and the MR pleiotropy residual sum and outlier test to determine whether a particular diet was causal for T2D.

Results

Reliable and robust MR estimates demonstrated that poultry intake has a causal effect on a higher risk of T2D (IVW: OR 6.30, 95% CI 3.573–11.11, p = 2.02e − 10; WMM: OR 5.479, 95% CI 0.2758–10.88, p = 1.19e − 06). Conversely, dried fruit intake (IVW: OR 0.380, 95% CI 0.237–0.608, p = 5.57e − 05; WMM: OR 0.450, 95% CI 0.321–0.630, p = 3.33e − 06) and cereal intake (IVW: OR 0.455, 95% CI 0.317–0.653, p = 1.924e − 05; WMM: OR 0.513, 95% CI 0.379–0.694, p = 1.514e − 05) were causally associated with T2D as protective factors. Sensitivity analyses confirmed the reliability and robustness of these findings.

Discussion

Our study established the causal effects of poultry intake, dried fruit intake, and cereal intake on T2D, identifying poultry intake as a risk factor and the other two as protective factors. Further research into potential mechanisms is required to validate these novel findings.
Phytochemical components analysis and hypolipidemic effect on hyperlipidemia mice of the aerial parts from Allium sativum
Authors: Hu Bin , Hu Haibo , Peng Donghui , Wei Zheng , Wang Qiuhong , Kuang Haixue
Published: July 2024

Background

The bulbs of Allium sativum are widely used as food or seasoning (garlic), while they have also been utilized as a famous traditional medicine since ancient eras for the treatment of scabies, tuberculosis, pertussis, diarrhea and dysentery, etc. However, very few studies focus on their abundant aerial parts, which are normally discarded during the harvest season.

Methods

The hyperlipidemic mice model has been used to study the lipid-lowering effect of the aerial parts in this article. 180 mice were randomly divided into 18 groups, including blank control (BC), model (Mod), positive control (PC), and low-, medium-, and high-dose groups of the crude extract, petroleum ether, ethyl acetate, n-butanol, and residual water extracts (corresponding to CE, PEE, EAE, NBE, WE), with 10 mice in each group. The preventive effects of the extracts on hyperlipidemic mice lasted for four weeks. Ultra performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF-MS) and gas chromatography tandem mass spectrometry (GC-MS/MS) were used to analyze the chemical components of NBE and PEE respectively.

Results

The results of the mice experiment showed that n-butanol extract (NBE) and petroleum ether extract (PEE) from the aerial parts could significantly reduce the contents of total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C), alanine transaminase (ALT) and aspartate transaminase (AST) in serum of hyperlipidemic mice, and increase the contents of high density lipoprotein cholesterol (HDL-C). They could enhance the activity of superoxide dismutase (SOD) in liver and reduce the level of malondialdehyde (MDA). At the same time, they could improve steatosis and inflammation of liver cells. The results of phytochemical components analysis showed that NBE was rich in organic acids, flavonoids and nitrogen-containing constituents, while PEE contained organic sulfur compounds, aliphatic acids and derivatives, alkaloids, phytosterols, etc.

Conclusion

These results support that the aerial parts of A. sativum are an interesting source of bioactive ingredients that may be useful in the prevention and treatment of hyperlipidemia.
Endoplasmic reticulum stress-related features predict the prognosis of osteosarcoma and reveal STC2 as a novel risk indicator for disease progression
Authors: Yu Yongle , Yu Jiadong , Pan Zhenyu
Published: July 2024

Endoplasmic reticulum (ER) stress exerts significant effects on cell growth, proliferation, migration, invasion, chemoresistance, and angiogenesis in various cancers. However, the impact of ER stress on the outcomes of osteosarcoma patients remains unclear. In this study, we established an ER stress risk model based on The Cancer Genome Atlas (TARGET) osteosarcoma dataset to reflect immune features and predict the prognosis of osteosarcoma patients. Survival analysis revealed significant differences in overall survival among osteosarcoma patients with different ER stress-related risk scores. Furthermore, ER stress-related risk features were significantly associated with the clinical pathological characteristics of osteosarcoma patients and could serve as independent prognostic indicators. Functional enrichment analysis indicated associations of the risk model with cell chemotaxis, leukocyte migration, and regulation of leukocyte migration. Additionally, the ER stress-related risk model suggested the presence of an immunosuppressive microenvironment and immune checkpoint responses. We validated the significance of 7 ER stress-related genes obtained from LASSO regression analysis through RT-qPCR testing on osteosarcoma samples from a local hospital, and inferred the importance of STC2 based on the literature. Subsequently, IHC experiments using samples from 70 osteosarcoma cases and 21 adjacent tissue samples confirmed differential expression of STC2 between cancer and normal tissues, and explored the gene’s expression in pan-cancer and its association with clinical pathological parameters of osteosarcoma. In conclusion, we have proposed an ER stress risk model as an independent prognostic factor and identified STC2 as a novel risk indicator for disease progression, providing a promising direction for further research and treatment of osteosarcoma.
Teenage parents and their children—position paper of the European academy of paediatrics and the European confederation of primary care paediatricians
Authors: Fontoura-Matias José , Chakhunashvili Davit George , Copley Sian , Dembiński Łukasz , Drosdzol-Cop Agnieszka , Hadjipanayis Adamos , Reali Laura , Mazur Artur
Published: July 2024

Introduction

Teenage parenthood presents multifaceted implications, affecting adolescent parents, their children, and extended families. Despite a decrease in teenage pregnancy rates across Europe, the phenomenon continues to present significant challenges, impacting not only the adolescent parents but also their offspring and extended families.

Methods

A comprehensive literature review was conducted. Key factors influencing teenage pregnancies, including socioeconomic background, family structure, and access to sex education and contraception, were examined. This review was supplemented by expert opinions from the European Academy of Paediatrics (EAP) and the European Confederation of Primary Care Paediatricians (ECPCP).

Results

The triad of mother, father, and child presents individual distinct healthcare needs and vulnerabilities, highlighting the importance of specialized support and healthcare. This paper explores the psychological, social, and educational repercussions of teenage parenthood on both parents and their children, including higher risks of postpartum depression, school dropout, and repeat pregnancies. Furthermore, it underscores the critical role that paediatricians and primary care providers play in supporting these young families.

Discussion

The position paper advocates for comprehensive care for adolescent parents and their children. It recommends preventive measures such as proper sex education and access to contraception to reduce unplanned teenage pregnancies. Additionally, it emphasizes the need for specialized healthcare and support for teenage parents to address their unique challenges and improve outcomes for both parents and their children.
Identification of potential inhibitors for drug-resistant EGFR mutations in non-small cell lung cancer using whole exome sequencing data
Authors: Nagarajan Nagasundaram , Guda Chittibabu
Published: July 2024

Epidermal growth factor receptor (EGFR) gene mutations are prevalent in about 50% of lung adenocarcinoma patients. Highly effective tyrosine kinase inhibitors (TKIs) targeting the EGFR protein have revolutionized treatment for the prevalent and aggressive lung malignancy. However, the emergence of new EGFR mutations and the rapid development of additional drug resistance mechanisms pose substantial challenge to the effective treatment of NSCLC. To investigate the underlying causes of drug resistance, we utilized next-generation sequencing data to analyse the genetic alterations in different tumor genomic states under the pressure of drug selection. This study involved a comprehensive analysis of whole exome sequencing data (WES) from NSCLC patients before and after treatment with afatinib and osimertinib with a goal to identify drug resistance mutations from the post-treatment WES data. We identified five EGFR single-point mutations (L718A, G724E, G724K, K745L, V851D) and one double mutation (T790M/L858R) associated with drug resistance. Through molecular docking, we observed that mutations, G724E, K745L, V851D, and T790M/L858R, have negatively affected the binding affinity with the FDA-approved drugs. Further, molecular dynamic simulations revealed the detrimental impact of these mutations on the binding efficacy. Finally, we conducted virtual screening against structurally similar compounds to afatinib and osimertinib and identified three compounds (CID 71496460, 73292362, and 73292545) that showed the potential to selectively inhibit EGFR despite the drug-resistance mutations. The WES-based study provides additional insight to understand the drug resistance mechanisms driven by tumor mutations and helps develop potential lead compounds to inhibit EGFR in the presence of drug resistance mutations.
Current concepts of the crosstalk between lncRNA and E2F1: shedding light on the cancer therapy
Authors: Huang Peng , Wen Feng , Li Qiu
Published: July 2024

Long noncoding RNAs (lncRNAs) constitute a distinctive subset of RNA molecules with limited protein-coding potential, which exert crucial impacts on various biological activities. In the context of cancer, dysregulated lncRNAs function as essential regulators that affect tumor initiation and malignant progression. These lncRNAs serve as competitive endogenous RNAs (ceRNAs) through sponging microRNAs and regulating the expression of targeted genes. Moreover, they also directly bind to RNA-binding proteins, which can be integrated into a complex mechanistic network. E2F1, an extensively studied transcription factor, mediates multiple malignant behaviors by regulating cell cycle progression, tumor metastasis, and therapeutic response. Emerging evidence suggests that lncRNAs play a pivotal role in regulating the E2F1 pathway. This review aims to elucidate the intricate gene regulatory programs between lncRNAs and E2F1 in cancer progression. We elaborate on distinct mechanistic networks involved in cancer progression, emphasizing the potential of the lncRNAs/E2F1 axes as promising targets for cancer therapy. Additionally, we provide novel perspectives on current evidence, limitations, and future directions for targeting lncRNAs in human cancers. Fully deciphering the intricate network of lncRNA/E2F1-mediated regulatory mechanisms in cancer could facilitate the translation of current findings into clinical course, such efforts ultimately significantly improve the clinical prognosis of cancer patients.
Nanocarrier drug delivery system: promising platform for targeted depression therapy
Authors: Feng Xiaoying , Jia Ping , Zhang Dingding
Published: July 2024

Depression is a chronic mental disorder characterized by persistent low mood and loss of interest. Treatments for depression are varied but may not be sufficient cure. Drug-based treatment regimens have drawbacks such as slow onset of action, low bioavailability, and drug side effects. Nanocarrier Drug Delivery Systems (NDDS) has received increasing attention for brain drug delivery since it assists the drug through the blood-brain barrier and improves bioavailability, which may be beneficial for treating depression. Due to the particle size and physicochemical properties of nanocarriers, it presents a promise to improve the stability and solubility of antidepressants, thereby enhancing the drug concentration. Moreover, ligand-modified nanocarriers can be taken as a target direct medicines release system and reduce drug side effects. The purpose of the present review is to provide an up-to-date understanding of the Nanocarrier drug delivery system and relevant antidepressants in different routes of ingestion, to lay a foundation for the treatment of patients with depression.
Stem traits promote wheat climate-resilience
Authors: Ntawuguranayo Simeon , Zilberberg Michael , Nashef Kamal , Bonfil David J. , Bainsla Naresh Kumar , Piñera-Chavez Francisco J. , Reynolds Matthew Paul , Peleg Zvi , Ben-David Roi
Published: July 2024

Introduction

Wheat grain filling processes under post-anthesis stress scenarios depend mainly on stem traits and remobilization of stem water-soluble carbohydrates (WSC).

Methods

A diverse panel of advanced semi-dwarf spring wheat lines, representing a natural variation in stem traits (WSC content, stem diameter, peduncle length, and stem wall width), was used to identify specific traits that reliably reflect the relationship between WSC and grain yield. The panel was phenotyped under various environmental conditions: well-watered, water-limited, and heat stress in Mexico, and terminal-drought in Israel.

Results

Environmental stresses reduced grain yield (from 626 g m−2 under well-watered to 213 g m−2 under heat), lower internode diameter, and peduncle length. However, stem-WSC generally peaked 3-4 weeks after heading under all environmental conditions except heat (where it peaked earlier) and expressed the highest values under water-limited and terminal-drought environments. Increased investment in internode diameter and peduncle length was associated with a higher accumulation of stem WSC, which showed a positive association with yield and kernel weight. Across all environments, there were no apparent trade-offs between increased crop investment in internode diameter, peduncle length, and grain yield.

Discussion

Our results showed that selecting for genotypes with higher resource investment in stem structural biomass, WSC accumulation, and remobilization could be a valuable strategy to ameliorate grain size reduction under stress without compromising grain yield potential. Furthermore, easy-to-measure proxies for WSC (stem diameter at specific internodes and length of the last internode, i.e., the peduncle) could significantly increase throughput, potentially at the breeding scale.
The hormone regulatory mechanism underlying parthenocarpic fruit formation in tomato
Authors: Guan Hongling , Yang Xiaolong , Lin Yuxiang , Xie Baoxing , Zhang Xinyue , Ma Chongjian , Xia Rui , Chen Riyuan , Hao Yanwei
Published: July 2024

Parthenocarpic fruits, known for their superior taste and reliable yields in adverse conditions, develop without the need for fertilization or pollination. Exploring the physiological and molecular mechanisms behind parthenocarpic fruit development holds both theoretical and practical significance, making it a crucial area of study. This review examines how plant hormones and MADS-box transcription factors control parthenocarpic fruit formation. It delves into various aspects of plant hormones-including auxin, gibberellic acid, cytokinins, ethylene, and abscisic acid—ranging from external application to biosynthesis, metabolism, signaling pathways, and their interplay in influencing parthenocarpic fruit development. The review also explores the involvement of MADS family gene functions in these processes. Lastly, we highlight existing knowledge gaps and propose directions for future research on parthenocarpy.
Navigating autonomy: unraveling the dual influence of job autonomy on workplace well-being in the gig economy
Authors: Wan Zhitao , Zhang Lei , Wang Li , Zhang Fang
Published: July 2024

Introduction

With the rapid rise of the gig economy globally, its characteristics of promoting employment and facilitating autonomy have supported its rapid growth and development in China. While the flexibility of gig work offers more employment options and income sources for workers, it also caused many problems and uncertainties. Workplace well-being is an important psychological factor that indicates the psychological state of workers and significantly predicts their behavior at work. However, previous studies on the gig economy rarely analyze gig workers’ workplace well-being, which is of great significance to improving their individual emotions, promoting their physical and mental health, and maintaining the sustainable development of the gig economy and society in general.

Methods

This study draws on the cognitive-affective processing system framework to construct a moderated dual-mediator model to explore the dual influence mechanism of job autonomy on gig workers’ workplace well-being. Based on the data of 442 digital gig workers who were mainly engaged in manual labor.

Results

The survey results show that job autonomy positively affects employees’ workplace well-being, and work alienation and positive emotion mediate this relationship. Perceived algorithmic control can moderate not only the influence of job autonomy on work alienation and positive emotion but also the indirect impact of job autonomy on workplace well-being through work alienation and positive emotion.

Discussion

The finding of this research contributes to expand the comprehension of the relationship between gig-worker job autonomy and workplace wellbeing and this relationship’s underlying mechanism, holding significant implications for management practice.
The importance of childhood social capitals in the future well-being of children
Authors: Hosoda Chihiro , YunFeng Zhang , Watanabe Junji , Maruya Kazushi , Tabuchi Rokuro , Hosokawa Kenchi , Matsuhashi Takuto
Published: July 2024

Introduction

Elucidating the enduring effects of childhood social capital is vital for shaping future well-being. Here, we investigate the impact of childhood social capital (SC) and parental engagement on adult psychological well-being and cognitive performance.

Methods

Utilizing a cohort of 292 Japanese university students, we assessed the influences of SC and parental time during childhood on adult outcomes. Participants retrospectively reported their early childhood experiences, focusing on social interactions and parental involvement.

Results

Our findings reveal a significant positive correlation between childhood SC and adult subjective well-being, particularly in its positive dimensions. Additionally, maternal involvement during childhood is associated with cognitive abilities in adulthood, as measured by Raven’s Advanced Progressive Matrices. Hierarchical multiple linear regression analysis highlights the substantial impact of childhood SC on adult well-being, elucidating the intricate interplay between social and parental contributions to developmental trajectories.

Discussion

These results highlight the crucial roles of both parental and non-parental figures in fostering social, emotional, and cognitive development from childhood to adulthood, underscoring the importance of nurturing supportive relationships throughout early life to promote positive developmental outcomes.
Exploring the association between atmospheric pollutants and preterm birth risk in a river valley city
Authors: Gu Jiajia , Li Jimin , Liu Lang , Cao Meiying , Tian Xi , Wang Zeqi , He Jinwei
Published: July 2024

Objective

To investigate the association between exposure to atmospheric pollutants and preterm birth in a river valley-type city and its critical exposure windows.

Methods

A retrospective cohort study was used to collect data from the medical records of preterm and full-term deliveries in two hospitals in urban areas of a typical river valley-type city from January 2018 to December 2019. A total of 7,288 cases were included in the study with general information such as pregnancy times, the number of cesarean sections, occupation, season of conception and regularity of the menstrual cycle. And confounding factors affecting preterm birth were inferred using the chi-square test. The effects of exposure to each pollutant, including particulate matter 2.5 (PM2.5), particulate matter 10 (PM10), nitrogen dioxide (NO2), sulfur dioxide (SO2), carbon monoxide (CO) and ozone (O3), during pregnancy on preterm birth and the main exposure windows were explored by establishing a logistic regression model with pollutants introduced as continuous variables.

Results

Maternal age, pregnancy times, number of births, number of cesarean sections, season of conception, complications diseases, comorbidities diseases, hypertension disorder of pregnancy and neonatal low birth weight of the newborn were significantly different between preterm and term pregnant women. Logistic regression analysis after adjusting for the above confounders showed that the risk of preterm birth increases by 0.9, 0.6, 2.4% in T2 and by 1.0, 0.9, 2.5% in T3 for each 10 μg/m3 increase in PM2.5, PM10, NO2 concentrations, respectively. The risk of preterm birth increases by 4.3% in T2 for each 10 μg/m3 increase in SO2 concentrations. The risk of preterm birth increases by 123.5% in T2 and increases by 188.5% in T3 for each 10 mg/m3 increase in CO concentrations.

Conclusion

Maternal exposure to PM2.5, PM10, NO2, CO was associated with increased risk on preterm birth in mid-pregnancy (T2) and late pregnancy (T3), SO2 exposure was associated with increased risk on preterm birth in mid-pregnancy (T2).
Mediating effects of self-esteem and self-compassion on the relationship between body dissatisfaction and depression among adolescents with polycystic ovary syndrome
Authors: Huangfu Huihui , Li Li , Shuai Wen
Published: July 2024

Introduction

Body dissatisfaction significantly impacts depression among adolescents with polycystic ovary syndrome (PCOS). This relationship is compounded by various factors. Our study aims to explore the roles of self-esteem and self-compassion in the relationship between body dissatisfaction and depression in adolescent with PCOS.

Methods

A cross-sectional study was conducted at the Shanghai First Maternity and Infant Hospital, involving 287 adolescents diagnosed with PCOS from January 2020 to December 2021. Participants completed validated questionnaires covering body dissatisfaction, self-esteem, self-compassion and depression. We utilized correlation and mediation analyses to examine the relationships and mediating effects among these variables.

Results

Body dissatisfaction had a significant positive effect on depression (β = 4.254, p < 0.001). Conversely, self-esteem (β = −0.944, p < 0.001) and self-compassion (β = −0.318, p < 0.001) were negative predictors of depression. Both self-esteem [β = 3.405, 95% CI = (0.151, 0.305)] and self-compassion [β = 1.525, 95% CI = (0.045, 0.165)] were shown to partially mediate the relationship between body dissatisfaction and depression, explaining 37.07% and 16.61% of the total effect, respectively.

Conclusion

This study highlights the importance of fostering self-esteem and self-compassion among adolescents with PCOS to buffer the depressive effects of body dissatisfaction. Interventions aimed at promoting accurate and positive body perceptions, enhancing self-esteem, fostering a supportive attitude toward personal challenges, and maintaining positive emotional states are recommended to decrease the incidence of depression.
Negative impact of nurses’ fear of COVID-19: the moderating role of implementation of knowledge management
Authors: Chu Li-Chuan
Published: July 2024

Background

During the COVID-19 pandemic, nurses encountered substantial infection risks and psychological strain, which severely affected their emotional well-being, professional attitudes, and job performance. This study investigated the impact of nurses’ fear of COVID-19 on their intention to leave the occupation and emotional labor as well as the moderating role of the implementation of knowledge management on these primary variables.

Methods

To mitigate common method bias, this research adopted a two-phase questionnaire approach, targeting nurses at a medical center in central Taiwan. In the first phase, 300 copies of questionnaire were distributed for participants to complete self-assessment surveys covering fear of COVID-19, knowledge management implementation, and demographic information. After 1 month, the participants were invited to complete a follow-up questionnaire, focusing on the intention to leave the occupation and emotional labor. The questionnaire was conducted from June to July 2022. Through this two-phase distribution method, after exclusion of invalid responses, a total of 288 valid responses were collected, resulting in a response rate of 96%. The proposed hypotheses were verified using hierarchical regression conducted with SPSS version 25.0.

Results

The findings indicated that nurses’ fear of COVID-19 was significantly and positively associated with their intention to leave the occupation and surface acting, but negatively associated with their deep acting. Moreover, the implementation of knowledge management significantly moderated the positive relationship among fear of COVID-19, intention to leave the occupation, and surface acting. A robust knowledge management system weakened the positive association among fear of COVID-19, intention to leave the occupation, and surface acting.

Conclusion

In summary, nurses’ fear of COVID-19 may increase their tendency to leave the nursing profession and engage in more surface acting and less deep acting. However, effective knowledge management practices can mitigate these adverse effects. Hospitals can thus establish and employ comprehensive knowledge management systems to enhance nurses’ resilience and help alleviate their fear of future pandemics and their potential negative repercussions.
Correlates of verbal and physical violence experienced and perpetrated among cisgender college women: serial cross-sections during one year of the COVID-19 pandemic
Authors: Theodore Deborah A. , Heck Craig J. , Huang Simian , Huang Yuije , Autry April , Sovic Brit , Yang Cynthia , Anderson-Burnett Sarah Ann , Ray Caroline , Austin Eloise , Rotbert Joshua , Zucker Jason , Catallozzi Marina , Castor Delivette , Sobieszczyk Magdalena E.
Published: July 2024

Introduction

Violence against women is a prevalent, preventable public health crisis. COVID-19 stressors and pandemic countermeasures may have exacerbated violence against women. Cisgender college women are particularly vulnerable to violence. Thus, we examined the prevalence and correlates of verbal/physical violence experienced and perpetrated among cisgender women enrolled at a New York City college over one year during the COVID-19 pandemic.

Methods

From a prospective cohort study, we analyzed data self-reported quarterly (T1, T2, T3, T4) between December 2020 and December 2021. Using generalized estimated equations (GEE) and logistic regression, we identified correlates of experienced and perpetrated violence among respondents who were partnered or cohabitating longitudinally and at each quarter, respectively. Multivariable models included all variables with unadjusted parameters X2p-value ≤0.05.

Results

The prevalence of experienced violence was 52% (T1: N = 513), 30% (T2: N = 305), 33% (T3: N = 238), and 17% (T4: N = 180); prevalence of perpetrated violence was 38%, 17%, 21%, and 9%. Baseline correlates of experienced violence averaged over time (GEE) included race, living situation, loneliness, and condom use; correlates of perpetrated violence were school year, living situation, and perceived social support. Quarter-specific associations corroborated population averages: living with family members and low social support were associated with experienced violence at all timepoints except T4. Low social support was associated with higher odds of perpetrated violence at T1/T3. Other/Multiracial identity was associated with higher odds of violence experience at T3.

Conclusions

Living situation was associated with experienced and perpetrated violence in all analyses, necessitating further exploration of household conditions, family dynamics, and interpersonal factors. The protective association of social support with experienced and perpetrated violence also warrants investigation into forms of social engagement and cohesion. Racial differences in violence also require examination. Our findings can inform university policy development on violence and future violence research. Within or beyond epidemic conditions, universities should assess and strengthen violence prevention and support systems for young women by developing programming to promote social cohesion.
Reliability and validity of sprint performance using the Alex7 motorized device
Authors: Skujytė Austra , Lukonaitienė Inga , Stanislovaitienė Jūratė , Šilinskas Viktoras , Bradauskienė Kristina , Mamkus Gediminas , Kamandulis Sigitas
Published: July 2024

Introduction

Advancements in technology have recently made it possible to implement effective training solutions across different environmental conditions. This study evaluated the reliability and validity of measures obtained from the innovative motorized device, Alex7 (Inosportas, Lithuania), and differences in speed and kinematic characteristics between resisted and assisted sprinting in young football players.

Methods

Twenty-seven male athletes (mean age: 16.5 ± 0.8 years; height: 179.5 ± 6.9 cm; body weight: 67.7 ± 8.3 kg) each performed 30-m sprints twice under three different conditions: regular, resisted, and assisted sprinting. The Alex7 device provided the assistance and resistance during sprints. Results were compared with those from Witty timing gates. Ground contact time, flight time, stride length, and pace were measured using the OptoJump system. Reliability was assessed using two-way mixed intraclass correlation coefficients (ICCs) for single measures, the standard error of the mean (SEM), and the coefficient of variation (CV). Pearson's correlation coefficient determined the associations between Alex7 and Witty timing systems. Criterion-referenced validity was based on the mean difference and CV. Systematic bias was determined by limits of agreement using Bland–Altman analysis.

Results

Running times obtained using the Alex7 equipment exhibited good to excellent test-retest reliability between sessions (ICC, 0.83–0.94) and good to excellent correlation (Pearson's r = 0.88–0.98) between the Alex7 and Witty systems in both assisted and resisted running conditions. However, the Alex7 device consistently produced longer running times than the Witty device (up to 0.16 s difference, p < 0.001). The different running conditions produced substantial variations in kinematic variables, such as stride length, ground contact time, and running speed (p < 0.001 for all), but the effects on flight time and running pace were smaller.

Discussion

The Alex7 device shows high reliability for creating resisted and assisted running conditions for young football players. However, it tends to overestimate running time, necessitating caution when assessing the time parameters.
Paraneoplastic Syndrome After Kidney Transplantation: Frequency, Risk Factors, Differences to Paraneoplastic Occurrence of Glomerulonephritis in the Native Kidney, and Implications on Long-Term Kidney Graft Function
Authors: Zakrocka Izabela , Nair Gayatri , Soler Maria Jose , Jhaveri Kenar D. , Kronbichler Andreas
Published: July 2024

Posttransplant malignancies are an important complication of solid organ transplantation. Kidney transplant recipients are at particularly high risk of cancer development. The most relevant risk factors of carcinogenesis are the use of immunosuppressive agents and oncogenic viral infections. Additionally, immune dysregulation caused by these factors may predispose to various types of organ damage. Paraneoplastic glomerular diseases are one of the most interesting and understudied cancer manifestations. The appropriate diagnosis of paraneoplastic glomerular damage can be challenging in kidney transplant recipients, due to factors inherent to concomitant medication and common comorbidities. Recent advances in the field of molecular and clinical nephrology led to a significant improvement in our understanding of glomerular diseases and their more targeted treatment. On the other hand, introduction of novel anticancer drugs tremendously increased patients’ survival, at the cost of kidney-related side effects. Our review aims to provide insights into diagnosis and treatment of paraneoplastic glomerular diseases, with a special attention to kidney transplant recipients.
A Quantum Approach for Exploring the Numerical Results of the Heat Equation
Authors: Daribayev Beimbet , Mukhanbet Aksultan , Azatbekuly Nurtugan , Imankulov Timur
Published: July 2024

This paper presents a quantum algorithm for solving the one-dimensional heat equation with Dirichlet boundary conditions. The algorithm utilizes discretization techniques and employs quantum gates to emulate the heat propagation operator. Central to the algorithm is the Trotter–Suzuki decomposition, enabling the simulation of the time evolution of the temperature distribution. The initial temperature distribution is encoded into quantum states, and the evolution of these states is driven by quantum gates tailored to mimic the heat propagation process. As per the literature, quantum algorithms exhibit an exponential computational speedup with increasing qubit counts, albeit facing challenges such as exponential growth in relative error and cost functions. This study addresses these challenges by assessing the potential impact of quantum simulations on heat conduction modeling. Simulation outcomes across various quantum devices, including simulators and real quantum computers, demonstrate a decrease in the relative error with an increasing number of qubits. Notably, simulators like the simulator_statevector exhibit lower relative errors compared to the ibmq_qasm_simulator and ibm_osaka. The proposed approach underscores the broader applicability of quantum computing in physical systems modeling, particularly in advancing heat conductivity analysis methods. Through its innovative approach, this study contributes to enhancing modeling accuracy and efficiency in heat conduction simulations across diverse domains.
A Study on Adaptive Implicit–Explicit and Explicit–Explicit Time Integration Procedures for Wave Propagation Analyses
Authors: Soares Delfim , Sales Isabelle de Souza , Pinto Lucas Ruffo , Mansur Webe João
Published: July 2024

This study delves into the effectiveness of two time integration techniques, namely the adaptive implicit–explicit (imp–exp) and explicit–explicit (exp–exp) methods, which stand as efficient formulations for tackling intricate systems characterized by multiple time scales. The imp–exp technique combines implicit and explicit procedures by employing implicit formulations for faster components and explicit calculations for slower ones, achieving high accuracy and computational efficiency. Conversely, the exp–exp method, a variation of explicit methods with sub-cycling, excels in handling locally stiff systems by employing smaller sub-steps to resolve rapid changes while maintaining stability. For both these approaches, numerical damping may be activated by adaptive time integration parameters, allowing numerical dissipation to be locally applied, if necessary, as a function of the considered discrete model and its computed responses, enabling a highly effective numerical dissipative algorithm. Furthermore, both these techniques stand as very simple and straightforward formulations as they rely solely on single-step displacement–velocity relations, describing truly self-starting procedures, and they stand as entirely automated methodologies, requiring no effort nor expertise from the user. This work provides comparative studies of the adaptive imp–exp and exp–exp approaches to assess their accuracy and efficiency across a wide range of scenarios, with emphasis on geophysical applications characterized by multiscale problems, aiming to establish under which circumstances one approach should be preferred over the other.
Restrain Performance of Child Restraint Systems for 1.5-Year-Old Children on Commercial Airplanes: An Experimental Study
Authors: Shi Xiaopeng , Zhou Yifan , Xiong Chen , Wang Yafeng , He Yonglong , Feng Zhenyu , Xie Jiang
Published: July 2024

This study aims to compare the restraint performance of two child restraint systems (CRSs) used on airplanes—a rear-facing child seat (RFCS) and the child aviation restraint system (CARES)—for 1.5-year-old children, along with their compatibility with different types of aircraft seats. 16 g longitudinal dynamic tests were conducted on two types of aircraft seats with CRSs. Results indicate poor compatibility of CARES with Type A seats, significantly increasing the risk of head, neck, and abdominal injuries, with Nij exceeding the acceptable limit. In contrast, CARES exhibited good compatibility with Type B seats and effectively protected children. RFCS tests demonstrated effective injury risk reduction on both types of seats. It can be found that the performance of CARES depends on restraint status and seat dimensions; RFCSs provide adequate protection for 1.5-year-olds. Optimal protection can be achieved with smaller restrain angles of CRS and using thinner seat cushions. Compared to CARES, RFCSs better adapt to various aircraft seat structures, offering superior child protection.