bluuebunny/crossref_metadata_2025 huggingface dataset:
Modelo de administración de marcas: un enfoque teórico basado en la teoría general de sistemas
Authors: Martín García Manuel , Bermúdez González Guillermo , Li Zhenxin , Parra Guerrero Francisca
Published: September 2022

Este artículo presenta un Modelo Sistémico de Administración de Marcas basado en las aportaciones de la literatura conceptual y empírica. El objetivo es analizar las aportaciones y proponer una serie de hipótesis que evidencien la interrelación entre los elementos considerados esenciales en el proceso de construcción de marcas.
Los resultados se han obtenido mediante un análisis cualitativo que ha llevado a la identificación de cuatro dimensiones esenciales en el proceso de administración de marcas: Identidad, Posicionamiento, Imagen formal y Comunicación. Se concluye que el modelo aportado es una herramienta útil para abordar de forma rigurosa los procesos de creación y auditoría de marcas.
Obrazovanje u periodu pandemije COVID-19
Authors: Stanić Milenko , Stanić Tamara
Published: September 2022

Pandemija virusa korona uticala je na promenu svih životnih segmenata, pa tako i na obrazovanje. Sa tradicionalnog obrazovanja škole i univerziteti prešli su na online učenje koje je predstavljalo veliki izazov kako za profesore tako i za učenike. Da li je online obrazovanje samo trenutna nužnost ili će svoju upotrebu imati i nakon pandemije korona virusa odgovorili smo u ovom radu.
The Correct Link to the Article: Sedaev P.V., Kochkurov A.S. — Traditionalist Philosophical Ideas of A. Onegova in his "Dialogue with conscience"
Authors: Sedaev Pavel Valerievich , Kochkurov Aleksandr Sergeevich
Published: September 2022

In this article, the subject of the study is the philosophical ideas of traditionalism, which were considered by writers-villagers and, in particular, by the writer A. Onegov. Russian people have these values, such as the cult of the family, the idea of a collective beginning in Russian society, the priority of the general over the private, a special attitude to work. These cultural values sharply distinguish the Russian civilization from the Western one, which is built largely on other grounds opposite to these. Unfortunately, those value foundations inherent in the Russian civilization and which were described by A. Onegov are largely lost. However, it is time to study and revive them. The main conclusions drawn by the authors should be considered that it is time to return to their Russian traditional values, especially since this is being talked about today from the highest tribunes in Russia. Summing up, we can confidently state the fact that the traditionalist ideas of A. Onegova, expressed by him in his work "Dialogue with Conscience" will be in demand today. He managed to grasp the necessary factors, the conditions without which modern Russian society cannot develop. The study of A. Onegov's literary heritage is important not only from an artistic but also from a philosophical point of view.
Innexin function dictates the spatial relationship between distal somatic cells in the Caenorhabditis elegans gonad without impacting the germline stem cell pool
Authors: Tolkin Theadora , Mohammad Ariz , Starich Todd A , Nguyen Ken CQ , Hall David H , Schedl Tim , Hubbard E Jane Albert , Greenstein David
Published: September 2022

Gap-junctional signaling mediates myriad cellular interactions in metazoans. Yet, how gap junctions control the positioning of cells in organs is not well understood. Innexins compose gap junctions in invertebrates and affect organ architecture. Here, we investigate the roles of gap-junctions in controlling distal somatic gonad architecture and its relationship to underlying germline stem cells in Caenorhabditis elegans. We show that a reduction of soma–germline gap-junctional activity causes displacement of distal sheath cells (Sh1) towards the distal end of the gonad. We confirm, by live imaging, transmission electron microscopy, and antibody staining, that bare regions—lacking somatic gonadal cell coverage of germ cells—are present between the distal tip cell (DTC) and Sh1, and we show that an innexin fusion protein used in a prior study encodes an antimorphic gap junction subunit that mispositions Sh1. We determine that, contrary to the model put forth in the prior study based on this fusion protein, Sh1 mispositioning does not markedly alter the position of the borders of the stem cell pool nor of the progenitor cell pool. Together, these results demonstrate that gap junctions can control the position of Sh1, but that Sh1 position is neither relevant for GLP-1/Notch signaling nor for the exit of germ cells from the stem cell pool.
The role of anterior insular cortex inputs to dorsolateral striatum in binge alcohol drinking
Authors: Haggerty David L , Munoz Braulio , Pennington Taylor , Viana Di Prisco Gonzalo , Grecco Gregory G , Atwood Brady K
Published: September 2022

How does binge drinking alcohol change synaptic function, and do these changes maintain binge consumption? The anterior insular cortex (AIC) and dorsolateral striatum (DLS) are brain regions implicated in alcohol use disorder. In male, but not female mice, we found that binge drinking alcohol produced glutamatergic synaptic adaptations selective to AIC inputs within the DLS. Photoexciting AIC→DLS circuitry in male mice during binge drinking decreased alcohol, but not water consumption and altered alcohol drinking mechanics. Further, drinking mechanics alone from drinking session data predicted alcohol-related circuit changes. AIC→DLS manipulation did not alter operant, valence, or anxiety-related behaviors. These findings suggest that alcohol-mediated changes at AIC inputs govern behavioral sequences that maintain binge drinking and may serve as a circuit-based biomarker for the development of alcohol use disorder.
Transient cell-in-cell formation underlies tumor relapse and resistance to immunotherapy
Authors: Gutwillig Amit , Santana-Magal Nadine , Farhat-Younis Leen , Rasoulouniriana Diana , Madi Asaf , Luxenburg Chen , Cohen Jonathan , Padmanabhan Krishnanand , Shomron Noam , Shapira Guy , Gleiberman Annette , Parikh Roma , Levy Carmit , Feinmesser Meora , Hershkovitz Dov , Zemser-Werner Valentina , Zlotnik Oran , Kroon Sanne , Hardt Wolf-Dietrich , Debets Reno , Reticker-Flynn Nathan Edward , Rider Peleg , Carmi Yaron
Published: September 2022

Despite the remarkable successes of cancer immunotherapies, the majority of patients will experience only partial response followed by relapse of resistant tumors. While treatment resistance has frequently been attributed to clonal selection and immunoediting, comparisons of paired primary and relapsed tumors in melanoma and breast cancers indicate that they share the majority of clones. Here, we demonstrate in both mouse models and clinical human samples that tumor cells evade immunotherapy by generating unique transient cell-in-cell structures, which are resistant to killing by T cells and chemotherapies. While the outer cells in this cell-in-cell formation are often killed by reactive T cells, the inner cells remain intact and disseminate into single tumor cells once T cells are no longer present. This formation is mediated predominantly by IFNγ-activated T cells, which subsequently induce phosphorylation of the transcription factors signal transducer and activator of transcription 3 (STAT3) and early growth response-1 (EGR-1) in tumor cells. Indeed, inhibiting these factors prior to immunotherapy significantly improves its therapeutic efficacy. Overall, this work highlights a currently insurmountable limitation of immunotherapy and reveals a previously unknown resistance mechanism which enables tumor cells to survive immune-mediated killing without altering their immunogenicity.
Importance of Estrogen Receptors in Aetiopathogenesis of Carpal Tunnel Syndrome among Postmenopausal Women
Authors: Peedikayil Faizal C , Avaneethram AR , Kottayi Soni , Premkumar Chandru T , Aparna TP , Aravind Athira
Published: September 2022

Introduction: Extrusion of periapical debris is one of the common problem encountered during root canal treatment. As the endodontic instruments differ in terms of design and use, apical extrusion of debris may vary. Aim: To determine the quantity of debris extruded apically during various hand and rotary assisted instrumentation in extracted primary single rooted teeth. Materials And Methods: This in-vitro study was conducted in Department of Paediatric and Preventive Dentistry at Kannur Dental College, Anjarakandy, Kannur, Kerala, India, from December 2020 to May 2021. Four file systems were compared i.e, two hand files (Kedo SH and Protaper hand) and two rotary files (Kedo SG blue and Pro AF baby gold) among 60 therapeutically extracted single rooted primary teeth. The tooth was inserted into Eppendorf tube till cementoenamel junction, access opening was done, pulp extirpated, working length determined with 10 size k file. After instrumentation, the tooth was washed with 10 mL of distilled water for debris collection. Tube was incubated at 70°c for drying and weighed to measure the collected debris. Data collected were analysed statistically using Independent t-test, One-way analysis of variance and Least Significant Difference (LSD) Post hoc test for multiple comparison to compare between the groups were done. Level of statistical significance was set at p-value<0.05. Results: There was significant difference in the amount of debris collected between the hand file and rotary files (p-value<0.001), between Kedo SG blue and Pro AF baby gold (p-value<0.001), and Kedo SH hand file and Protaper hand file (p-value<0.05). Conclusion: Rotary files shows lesser amount of debris extrusion than the hand files. Comparing the four file system Kedo SG Blue file shows least periapical debris extrusion, the second least is Pro AF Baby Gold (rotary), then Kedo SH hand file and last Protaper hand file.
An Assessment of the Marketing Challenges Faced by Cashew Farmers in Kombo South District of The Gambia
Authors: Gomez David , Fatty Lamin K. M. , Pinga Esther Seember , Gomez Mariama
Published: September 2022

Aims: This study examined the marketing challenges faced by cashew farmers in Kombo South District of The Gambia. The objectives of the study were to ascertain the challenges faced by cashew farmers and to identify ways of mitigating them in the study area.

Study Design: Descriptive research design.

Place and Duration of Study: The was conducted in Kombo South District of the Gambia between June and August, 2020.

Methodology: The study included all male and female farmers within the ages of 18-75 years in the villages that constitute the Kombo South District in the Gambia. A sample of 384 cashew famers was selected from a population of 9318 farmers using Taro Yamane formula.

Results: The findings of the study revealed that majority of farmers are affected by unstable domestic market prices of raw cashew nuts, lack of market information, poor road networks, large number of middlemen, lack of modern packaging materials, inadequate storage facilities, weak or no cashew farmer organizations, and the presence of pest and diseases.

Conclusion: The study, therefore recommended that the government and other relevant stakeholders should help in providing timely market information especially with regards to current prices of raw cashew nuts, rehabilitation of road networks and telecommunication systems to allow farmers to verify prices or sell in better markets, provision of modern packaging materials, adequate storage facilities and trainings on formation and management of farmer organizations will be vital for cashew farmers.
Generalized Moment Generating Functions for Some Continuous Multivariate Probability Distributions
Authors: Michael Matthew Chukwuma
Published: September 2022

The traditional moment generating functions of random variables and their probability distributions are known to not exist for all distributions and/or at all points and, where they exist, serious difficult and tedious manipulations are needed for the evaluation of higher central and non-central moments. This paper developed the generalized multivariate moment generating function for some random vectors/matrices and their probability distribution functions with the intention to replace the traditional/conventional moment generating functions due to their simplicity and versatility. The new functions were developed for the multivariate gamma family of distributions, the multivariate normal and the dirrichlet distributions as a binomial expansion of the expected value of an exponent of a random vector/matrix about an arbitrarily chosen constant. The functions were used to generate moments of random vectors/matrices and their probability distribution functions and the results obtained were compared with those from existing traditional/conventional methods. It was observed that the functions generated same results as the traditional/conventional methods; in addition, they generated both central and non-central moments in the same simple way without requiring further tedious manipulations; they gave more information about the distributions, for instance while the traditional method gives skewness and kurtosis values of  and  respectively for -variate multivariate normal distribution, the new methods gives ((0))p*1  and  respectively and; they could generate moments of integral and real powers of random vectors/matrices.
Effect of Soil Test Crop Response Based Long-Term Fertilization on Yield Attributing Parameters and Yield of Wheat (Triticum aestivum L.)
Authors: Bhayal Divya , Kulhare P. S. , Tagore G. S. , Bhayal Lalita , Aakash . , Upadhyay A. K.
Published: September 2022

A field experiment was carried out during Rabi season of 2020‒2021 and 2021‒2022 at the Jawaharlal Nehru Krishi Vishwa Vidyalaya (JNKVV), Jabalpur (Madhya Pradesh) at research field of department of soil science to find out the effect of soil test crop response based long-term fertilization on yield attributing parameters and yield of wheat. The treatments details were T1; Control, T2 ; 120 N: 80 P2O5: 60 K2O kg ha-1 , T3; Target yield of 4.5 t ha-1, T4; Target yield of 6.0 t ha-1, T5; Target yield of 4.5 t+FYM 5 t ha-1; T6; Target yield of 6.0 t+FYM 5 t ha-1 and carried out in Randomized Block Design (RBD) with four replications. Research findings of long term field experiment revealed that application of soil test crop response recommendation for target yield of 6.0 t ha-1+FYM 5 t ha-1 gave maximum earhead length (14.59 and 14.10 cm), number of grains ear-1 (66.46 and 63.30), test weight (41.93 and 41.35 g), grain yield (5568 and 5052 kg ha-1) and straw yield (7315 and 5969 kg ha-1) of wheat. The balanced application of fertilizers by the soil and the crop's needs for potential growth and development may account for the increased yield under the STCR technique with and without FYM. The inclusion of FYM resulted in a potential movement of water, air, temperature, and nutrients in the soil, which may have improved the conditioning of the rhizospheric environment and further raised yield when integrated with STCR. Due to better physical, chemical, and biological characteristics, enhanced microbial activity and the conversion of inaccessible nutrients into available forms, this STCR technique also aids in higher production.
Performance Evaluation of Tractor Operated Sugarcane Leaf Stripper through Analysis of Effect of Length, Girth and Number of Buds of Sugarcane
Authors: Patel Anurag , Moses Sheen Cline , D’souza Prashant M. , Alam Rana N.
Published: September 2022

In this present research paper analysis of the performance of tractor-operated sugarcane leaf stripper is performed. India is the second-largest producer of sugarcane and Sugarcane is the most prominent cash crop. The sugarcane harvesting process is labour intensive and takes around 850-1000 working man-hours per hectare when sugarcane is harvested manually and de-trashing alone takes 400 man-hours in manual harvesting procedures for removal of tops.

Mechanized leaf stripper is developed and fabricated to prevent labour and accident and the performance of the machine is evaluated on MCO-238, K-269 and R-94184 variety of sugarcane. The data regarding de-topping time and stripping rate are taken and the effect of parameters namely Length of, Girth and number of Buds of the stalk are evaluated. The machine was operated at a roller speed of rpm. The results showed that length and number of buds affect the stripping time significantly and the length of stalk and girth of the stalk has a significant impact on the stripping rate. For stripping rate the most dominant and significant factor was the length of the stalk: MOC-238 has 62.35% contribution, K-269 has 78.10% contribution and a case of R-94184 has 60.72% contribution. The second significant factors were girth with the contribution of 33.30%, 20.53% and 36.44% contribution in MCO-238, K-269 and R-94184 varieties respectively. The factor, number of buds remained insignificant.
Comparative Study of Nutrient Release Pattern from Nutripellet Pack and Polycoat Paper Encapsulated Fertilizer Pack Placed in Soils
Authors: Muthukrishnan R. , Nandhakumar M. R. , Arulmozhiselvan K. , Padmavathi T.
Published: September 2022

Nutripellet pack is a tubular assembly composed of fertilizer pellet, manure pellet and bioinoculants. A laboratory electrolyte release study was conducted to assess the extent of nutrient enrichment by nutrient release from encapsulated fertilizer pellet. Nutripellet pack and fertilizer pellet pack was placed in soil, within a closed container. Periodically the entire soil was removed for the estimation of soil reaction (pH), electrical conductivity (EC) and available forms of N, P and K up to 11 weeks after incubation (WAI).  Before the analysis the residual encapsulated pellet was removed. The treatments comprising the sources of fertilizers (N for urea, P for DAP or SSP and K for MOP), levels of nutrient release pore (0, 25 micro pores) in fertilizer pellet and Nutripellet pack (fertilizer pellet + manure pellet) placement in sand, red soil and hill soil. High available N, P and K observed with Nutripellet pack with NP (DAP) K was registered in sand, red and hilly soils.
Multivariate Analysis in Blackgram (Vigna mungo L. Hepper) Genotypes in India
Authors: Reddy Palle Siva Sainath , Lal Gabriyal M. , Bara Bineeta M. , Vamsi Parvathaneni
Published: September 2022

The present study was contained black gram, 40 genotypes and experiment will be carried out in Randomized block design with 3 replications. The higher GCV & PCV found in biological yield, harvest index, number of cluster per plant, number of primary branches per plant. The traits were biological yield, harvest index, number of cluster per plant, number of primary branches per plant, seed yield per plant, seed index exposed higher heritability and higher genetic advance as percentage of mean. Regarding on D2 values 40 black gram genotypes grouped in to 5 clusters. The intra cluster distance ranged from 0 to 30.38. The highest intra cluster distance found in cluster II (30.38). The highest inter cluster distance found between clusters III to cluster IV (168.86). The first principal component was more positively related to seed yield and its contributing traits such as days to maturity (0.305), biological yield (0.203), days to 50% flowering (0.180), seed index (0.018). The positive and negative loading shows the presence of positive and negative correlation trends between the components and the variables.
Effect of NPK and Nano Fertilizers on Plant Growth, Yield and Quality of Gladiolus (Gladiolus grandiflorus L.)
Authors: Srisha V. , Prasad V. M.
Published: September 2022

The current experiment was conducted in the Research Field of the Department of Horticulture, SHUATS, Prayagraj, from November 2021 to March 2022. The goal of the experiment, which used a Randomized Block Design (RBD) with eight treatments and three replications, was to determine which variety will grow best in Prayagraj agroclimatic conditions. It is determined from the current experimental results that the eight treatments in the American beauty variety under consideration demonstrated substantial diversity in all the parameters noted. to investigate "The Effect of NPK and Nano Fertilizer on Growth, Yield, and Quality of Gladiolus (Gladiolus grandiflorus L)". The best growth in plant height (116.22cm), number of leaves (14.0), number of shoots 50% sprouting (19.73), spike length (72.33 cm), and first spike emergence were all recorded (76.8), days it took for the first flower to bloom (118.44 ) 50% florets (106.88 ), spike weight (93.81 gm), and first and second floret flower diameter (6.27, 6.01 cm) Corms per plant (2.33 gm), corms per plot (20.31), vase life (11.5), number of spikes (1.83), and number of florets(12.77) compared to other treatments, T5 nano iron 0.25g/l offered the best results in terms of gladiolus growth, yield, and quality. The highest T5 nano iron 0.25g/l net income was (1563017) Rs./Ha, the highest gross return was (2187165) Rs./Ha, and the highest BC ratio was (1:2.5).
Challenges of Universal Health Coverage in Nigeria: Urgent Action for Health System that Protects Everyone
Authors: Abonyi Emmanuel Ebuka , Oliorah Patrick Ifechukwu , Onyemelukwe Blessing Chisom , Ideh Kenneth Nnaedozie , Ndenojuo Justin Chinazor , Obanwudeh Judith Obiageli
Published: September 2022

The declaration of universal health coverage (UHC) as a sustainable development goal (SDG), in 2015 was a global resolution to building a world free of diseases and disease-related deaths. The goal is in tandem with many other work frames of the United Nations under the chaperone of the World health organization to create a healthier society. Hence, every country under the United Nations agreed to pursue this mission as part of the UN’s sustainable development goals, targeting 2030 as the project finish line. Improving health service coverage and health outcomes depends on the availability, accessibility, and capacity of the healthcare system and care providers to deliver quality and people-centred integrated care. In this regard, Nigeria has adopted several approaches to ensure the implementation of the UHC even amidst enormous challenges. This article has critically examined common but prominent factors beclouding the attainment of UHC, SDG in Nigeria. Key factors such as the primary healthcare system and health insurance schemes have been identified as major concerns while few recommendations have also been prescribed to improve the existing structures.
A cirurgia robótica e o processo de enfermagem no período perioperatório: revisão integrativa
Authors: Vitoriano Laís Vilanova T. , Da Palma Sobrinho Natália , Machado Daniel Aragão
Published: September 2022

Objetivo: Conhecer a produção científica sobre o processo de enfermagem frente à cirurgia robótica no perioperatório. Método: Revisão integrativa, busca nas bases de dados: US National Library of Medicine National Institutes of Health, Biblioteca Virtual em Saúde e Cumulative Index to Nursing and Allied Health Literature, realizada entre junho e julho de 2021; 10 artigos selecionados atendiam aos critérios de inclusão. Resultados:  Predominaram artigos publicados em periódicos brasileiros, com 06 artigos no idioma português, 03 no inglês e 01 artigo no espanhol. Identificou-se duas categorias onde o processo de trabalho da enfermagem está inserido, a assistencial, com foco no intraoperatório e a gerencial com ações para a implementação da cirurgia robótica. Conclusão: A literatura científica ainda é muito voltada para questões de técnicas cirúrgicas, entretanto é possível observar um movimento tímido da enfermagem brasileira nos últimos anos, com discretas publicações sobre a atuação da enfermagem frente à cirurgia robótica.
A systems biological analysis of the ATF4‐GADD34‐CHOP regulatory triangle upon endoplasmic reticulum stress
Authors: Márton Margita , Bánhegyi Gábor , Gyöngyösi Norbert , Kálmán Eszter Éva , Pettkó‐Szandtner Aladár , Káldi Krisztina , Kapuy Orsolya
Published: September 2022

Endoplasmic reticulum (ER) stress‐dependent accumulation of incorrectly folded proteins leads to activation of the unfolded protein response. The role of the unfolded protein response (UPR) is to avoid cell damage and restore the homeostatic state by autophagy; however, excessive ER stress results in apoptosis. Here we investigated the ER stress‐dependent feedback loops inside one of the UPR branches by focusing on PERK‐induced ATF4 and its two targets, called CHOP and GADD34. Our goal was to qualitatively describe the dynamic behavior of the system by exploring the key regulatory motifs using both molecular and theoretical biological techniques. Using the HEK293T cell line as a model system, we confirmed that the life‐or‐death decision is strictly regulated. We investigated the dynamic characteristics of the crucial elements of the PERK pathway at both the RNA and protein level upon tolerable and excessive levels of ER stress. Of particular note, inhibition of GADD34 or CHOP resulted in various phenotypes upon high levels of ER stress. Our computer simulations suggest the existence of two new feedback loops inside the UPR. First, GADD34 seems to have a positive effect on ATF4 activity, while CHOP inhibits it. We claim that these newly described feedback loops ensure the fine‐tuning of the ATF4‐dependent stress response mechanism of the cell.
Efficient Short‐Wave Infrared Light‐Emitting Diodes Based on Heavy‐Metal‐Free Quantum Dots
Authors: Zhao Xiaofei , Lim Li Jun , Ang Shun Sheng , Tan Zhi‐Kuang
Published: September 2022

Short‐wave infrared (SWIR) light emission is important for a diverse range of modern applications, such as eye‐safe depth sensing, light detection and ranging (LiDAR), facial recognition, eye tracking, optical communication, and health‐monitoring technologies. However, there are a very limited number of known semiconductors that can emit efficiently in the SWIR spectral range. Presently, SWIR light‐emitting diodes (LEDs) based on colloidal quantum dots (CQD) are dominated by lead chalcogenide systems, despite the presence of heavy metal and modest efficiencies. Here, a highly efficient SWIR LED based on heavy‐metal‐free indium arsenide (InAs) core–shell CQDs is presented. In the LED design, the implementation of an otherwise hole‐transporting poly(vinylcarbazole) (PVK) layer on the electron‐injecting side of the device stack leads to a surprising enhancement in device performance, giving remarkably high external quantum efficiencies (EQEs) of 13.3% at 1006 nm. Single‐carrier device and optical investigations reveal the origins of enhancement to be the electronic decoupling of the CQD layer with the electron‐injecting zinc oxide (ZnO) layer, which mitigates luminescence quenching and improves charge balance. This work marks one of the highest efficiencies reported for heavy‐metal‐free solution‐processed LEDs in the SWIR spectral region, and can find significant applications in emerging consumer electronic technologies.
Designing of Interdigitated Coordination Polymer for Fluorogenic Sensing of Pd(II) in Water with Reversible Nonphase Mechanochromism
Authors: Dutta Basudeb , Debsharma Kingshuk , Dey Sunanda , Naaz Sanobar , Sinha Chittaranjan , Mir Mohammad Hedayetullah
Published: September 2022

In the present study, a novel interdigitated coordination polymer (CP) [Zn(cit)(4‐nvp)]n (1) is synthesized using citraconic acid (H2cit) and 4‐(1‐naphthylvinyl)pyridine (4‐nvp) mixed ligands. The efficient dipolar interactions between CP and polar solvents cause the observed redshift in emission spectra and rationalize the positive solvatochromism effect with increased Stokes shift (Δδ) from 5643 to 8547 cm−1 on going from less‐polar to more‐polar solvents. Supramolecular assembly of CP acts as a selective optical sensor toward Pd(II) even in the presence of other relevant contending metal ions in water. Inspired from the solution‐phase sensor activity, the CP is further employed for an on‐site and ecologically green contact mode detection of Pd(II) from water upon readily fabricating cost‐effective and portable thin film via simply drop‐casting aqueous suspension of material (1 mm) on filter paper. Interestingly, the compound exhibits the rare mechanochromic behavior upon external pressure. Hence, the synthesized CP reveals sensing activity in diverse way; in one hand, it demonstrates solvatochromism and, in other hand, it unveils mechanochromism accompanied by the detection of Pd(II) in aqueous medium.
Hollow Ni/Co‐MOFs with Controllable Surface Structure as Electrode Materials for High Performance Supercapacitors
Authors: Zhang Xu , Liu Zhiqing , Qu Ning , Lu Wang , Yang Shixuan , Tian Yuhan , Zhang Qiang , Zhao Yingyuan
Published: September 2022

The metal‐organic frameworks (MOFs) with redox active metal ions and diverse organic linkers have been broadly investigated as the expecting electrode materials for supercapacitors. Here, the hollow Ni/Co‐MOFs with uniform and small protrusions can be obtained by a simple one‐pot solvothermal process, controlling the size of the protrusions on the MOFs surface by regulating the molar ratio between metal ions and trimesic acid linkers. The small protrusions can supply plenty of redox sites for the electrochemical reactions while the hollow spheres should offer sufficient contact area for the electrolyte to reduce the ion transport resistance. The prepared Ni/Co‐MOFs exhibit promising performance in the supercapacitors. The Ni/Co‐MOF with ratio of 1:1 (metal ions:trimesic acid linkers) gives outstanding performance that the specific capacity can reach 828 C g−1 when the current density is 1 A g−1 and the rate capability can reach 68% at 20 A g−1. This work may cast light on tuning the structure of MOFs to boost electrochemical capacity.
Iterative synthesis, structures, and properties of acyclic and cyclic acridone oligomers
Authors: Komori Takashi , Tsurumaki Eiji , Toyota Shinji
Published: September 2022

Acyclic and cyclic acridone‐2,7‐diyl oligomers were synthesized by an iterative procedure from 10‐mesitylacridone as heteroatom containing π‐conjugated compounds. The oligomeric chain was elongated by a combination of regioselective bromination, borylation, Ni(0)‐mediated homocoupling, and Suzuki‐Miyaura coupling up to acyclic hexamer. Subsequently, the cyclic hexamer was synthesized by the bromination and intramolecular coupling of the acyclic hexamer. The DFT calculations revealed that the acyclic oligomers preferred to take extended structures with anti conformations, whereas the cyclic hexamer took a macrocyclic structure with syn conformations. The UV/Vis and fluorescence spectra of the series of oligomers were measured, and the effects of the chain length and the cyclization are discussed in terms of π‐conjugation.
Cancer and chemicals: A research‐inspired laboratory exercise based on the Ames test for mutagenicity
Authors: Large Delaney N. , Van Doorn Nathaniel A. , Timmons Shannon C.
Published: September 2022

Laboratory courses should cultivate enthusiasm for research and an appreciation for real‐world scientific challenges to retain undergraduate students and encourage them to pursue STEM‐related careers. Course‐based undergraduate research experiences (CURE) have emerged as an inclusive pedagogical model that facilitates laboratory skill development, while also improving self‐efficacy and critical thinking skills. Herein, an innovative research‐inspired Ames test for mutagenicity project is described. Students choose their own project theme and investigate substances using both TA98 and TA100 strains of Salmonella typhimurium to evaluate the potential for frameshift mutations and base‐pair substitutions, respectively. An appropriate test concentration of each substance is first determined via a cytotoxicity assay, providing an additional learning opportunity. Students also study the mutagenicity of test substance metabolites using commercially available rat liver extracts to simulate metabolism. Overall, these experiences provide a comprehensive research project with high relevancy to human health and real‐world importance. This laboratory module was assessed using CURE pre‐ and post‐course surveys to evaluate learning gains and benefits. Assessment data illustrated that students appreciated the discovery aspect of the research project and gained skills related to reading scientific literature and effective poster presentations. Student‐reported benefits of research project participation included learning new laboratory techniques, enhanced scientific writing skills, an increased tolerance for and understanding of common research challenges, and the confidence to tackle more complex research endeavors. Narrative feedback from students was very positive, with project highlights being the opportunity to select their own test substances and create new knowledge, as well as the analysis of results.
Differences in sensitivity to new therapies between primary and metastatic breast cancer: A need to stratify the tumor response?
Authors: Beaumont Hubert , Faye Nathalie , Iannessi Antoine , Chamorey Emmanuel , Klifa Catherine , Hsieh Chih‐Yi
Published: September 2022

Objective

We compared therapeutic response of Varlitinib + Capecitabine (VC) versus Lapatinib + Capecitabine (LC) in patients with human epidermal growth factor receptor 2‐positive metastatic breast cancer after trastuzumab therapy by assessing changes in target lesion (TL) diameter and volume per location.

Methods

We retrospectively analyzed the CT data of the ASLAN001‐003 study (NCT02338245). We analyzed TL size and number at each location focusing on therapeutic response from baseline to Week 12. We used TL diameter and volume to conduct an inter‐arm comparison of the response according to: RECIST 1.1; stratified per TL location and considering TLs independently. Multiple pairwise intra‐arm comparisons of therapeutic responses were performed. Considering TL independently, weighted models were designed by adding weighted mean TL responses grouped by location.

Results

We evaluated 42 patients (88 TL) and 35 patients (74 TL), respectively, at baseline and Week 12.

We found reductions in breast TL burden in the VC arm compared to the LC arm (p = 0.002 (diameter), p < 0.001 (volume)). Responses and TL sizes at baseline were not correlated.

Explained variabilities of volume change per TL location, patient and patient:TL interaction were 36%, 10% and 4% (VC), and 13%, 1% and 23%, (LC).

A test of inter‐arm difference of responses yielded p = 0.07 (diameter), and p < 0.001 (volume).

Conclusions

The therapeutic responses differed across tumors' locations; the magnitude of the differences of responses across the tumors' locations were drug‐dependent. Stratified analysis of the response by tumor location improved drug comparisons and is a powerful tool to understand TL heterogeneity.
Ulcer in a dialysis patient: Calciphylaxis or something simpler
Authors: Mohamed Amr , Thabet Salem
Published: September 2022

Ulcers in dialysis patients have multiple etiologies; uremic pruritis is common in dialysis patients and is associated with poor outcomes; however, it is more likely to be underdiagnosed as we usually think about more serious etiologies as calciphylaxis. Here, we present a case where uremic pruritis was the leading diagnosis.
Parapharyngeal and floor‐of‐mouth abscess secondary to tonsillar phlegmon: A rare and unusual cause of Ludwig's angina
Authors: Tailor Bhavesh V. , Devakumar Haran , Myuran Tharsika , Ioannidis Dimitrios
Published: September 2022

We present an unusual case of Ludwig's angina secondary to a left tonsillar phlegmon in a previously fit and well 50‐year‐old woman. This tonsillar phlegmon spread along the peritonsillar/parapharyngeal plane to cause a diffuse cellulitis and collection in the submental, sublingual, and submandibular spaces despite empirical intravenous antibiotic therapy.
Multiple sclerosis in sarcoidosis patients: Two case reports
Authors: Etemadifar Masoud , Mehri Armin , Sedaghat Nahad , Salari Mehri , Tavassoli Naini Parsa
Published: September 2022

Two cases of sarcoidosis referred to our clinic with neurological symptoms. They were diagnosed with multiple sclerosis using non‐invasive studies. The first patient refused treatment and died of myocardial infarction 6 months after visiting our clinic. The second received interferon‐beta and methotrexate with a favorable outcome after 3 years. Since the possible similar presentation of the two conditions could appear indistinct for certain diagnosis, accurate evaluation of symptoms and paraclinical data can provide the best approach to each condition.
In‐Situ‐Generated MoO2 on MoS2/ZnO Heterostructures with Enriched S,O‐Vacancies for Enhanced Electrocatalytic Reduction of N2 to NH3
Authors: Chen Shaona , Zhou Zhangyu , Bai Binbin , Dai Zhongxu , Shi Jinjin
Published: September 2022

Electrocatalytic nitrogen reduction reaction (NRR) is a green method for synthesis ammonia under mild condition compared to energy‐intensive Haber‐Bosch process. Herein, a novel heterojunction material (MMZ‐900) is prepared as an excellent electrocatalyst for NRR at 900 °C, which is composed of MoS2, MoO2 and ZnO with nonuniform charge distribution of rich S and O vacancies. As a result, MMZ‐900 exhibits about 8 times higher Faradaic efficiency and 5 times higher NH3 yields for NRR than pure MoS2, respectively. These new insights may open up opportunities for exploiting efficient NRR electrocatalysts by simultaneously improving sulfur and oxygen vacancies on heterojunction material.
Zum Potential unterschiedlicher Methoden beim Einlaminieren struktureller Metallverbinder
Authors: Fildhuth Thiemo , Oppe Matthias
Published: September 2022

In Verbundglas mittels Interlayer einlaminierte, strukturelle Metallverbinder (Fittings) stellen aufgrund ihrer mechanischen und gestalterischen Eigenschaften eine geeignete Fügemethode für lastabtragende Glaskonstruktionen dar. Dabei sind die Vorteile des Klebens für den Lasteintrag in das Glas und die Duktilität des Fittings unter dem Aspekt der Sicherheit nutzbar. Die Fittings werden entweder in taschenartige Aussparungen im Glas oder in den dünnen Raum zwischen zwei Glasscheiben einlaminiert. Anhand zweier ausgeführter Projekte, eines Flagshipstores und einer Glasschale, wird das Tragverhalten der unterschiedlichen Konstruktionsweisen beispielhaft anhand numerischer Analysen, Variantenstudien sowie mittels Bauteilversuchen untersucht.

On the potential of various methods of laminating structural glass fittings. Owing to their mechanical and design properties, metallic fittings bonded into laminated glass via the interlayer represent a suitable structural joining method for load bearing glass constructions. The advantages of adhesive bonding for a homogeneous load transfer to the glass and the ductility of the fittings can be exploited with respect to the safety concept. Fittings can either be laminated into pocket‐like cutouts in the center glass layer or into the thin interstice between two glass panes. The examples of two completed projects, a flagship store and a modular glass shell, are presented to investigate the load bearing behavior of these different fitting methods by means of numerical analyses, variant studies and component tests.
Schädigungseffekte in weichen Polymeren für Glasstrukturverbindungen
Authors: Euchler Eric , Bernhardt Ricardo , Schneider Konrad , Wießner Sven , Stommel Markus
Published: September 2022

Eine typische Verbindungstechnik für Glasstrukturen ist der laminierte Verbund mit weichen polymerbasierten Klebstoffen, wie Silikon. Infolge geometrischer Zwänge im laminierten Verbund, zeigen diese ein spezifisches mechanisches Verhalten: Eine sich unter Deformation einstellende überhöhte Spannungsmehrachsigkeit kann zur Kavitation führen. Zur Beschreibung dieses Schädigungsmechanismus unter praxisrelevanten Bedingungen sind angepasste, innovative Prüfmethoden wie die In situ‐Dilatometrie und Röntgen‐Mikrotomographie erforderlich. Diese sich ergänzenden experimentellen Ansätze ermöglichen sowohl präzise als auch ortsaufgelöste Informationen zur Entwicklung von Kavitäten in weichen Polymeren wie Elastomeren und Klebstoffen.

Damage effects in soft polymeric adhesives for glass structure connections. A typical joining technique for glass structures is the laminated joint by soft polymer‐based adhesives such as silicone. As a result of geometric constraints within the laminate, the polymers exhibit specific mechanical behavior: An excessive deformation‐induced stress multiaxiality can lead to cavitation. To describe this damage mechanism under practically relevant conditions, advanced and innovative testing methods, such as in situ dilatometry and X‐ray microtomography, are required. These complementary experimental approaches provide both precise and spatially resolved information on the development of cavities in soft polymers, such as elastomers and adhesives.
Redundante Punkthaltersysteme im Konstruktiven Glasbau durch hybride Verklebung
Authors: Offereins Dominik , Siebert Geralt
Published: September 2022

Die Untersuchung von Klebverbindungen im Konstruktiven Glasbau stellt gegenwärtig ein sehr aktives Forschungsgebiet dar. Das Konzept der hybriden Verklebung bezieht sich dabei auf Punkthaltersysteme, die Fassadenverglasungen mit der tragenden Unterkonstruktion verbinden. Dabei wird durch die Kombination eines steifen Primärklebstoffs mit einem weicheren Sekundärklebstoff ein redundantes Tragverhalten erzeugt. Zur Untersuchung der generellen Machbarkeit des Systems wurden uniaxiale Zugversuche im gealterten und ungealterten Zustand an einem weichen strukturellen Silikonklebstoff und einem steifen Epoxidharzklebstoff durchgeführt. Mit den gewonnenen Versuchsdaten wurde zudem jeweils ein erstes Materialmodell in einer FEM‐Software erstellt.

Redundant point‐fixings in structural glazing applications using hybrid bonding. The investigation of bonded joints in structural glazing is currently a very active field of research. The concept of hybrid bonding refers to point‐fixing systems that connect facade glazing to the steel substructure. A redundant load‐bearing behavior is created by combining a stiff primary adhesive with a softer secondary adhesive. To investigate the general feasibility of the system, uniaxial tensile tests were performed in the aged and unaged conditions on a soft structural silicone adhesive and a stiff epoxy resin adhesive. The test data obtained were also used to create an initial material model in FEM software in each case.
Isolierglasrandverbund auf beschichteten und digital bedruckten Glasoberflächen
Authors: Wünsch Jan , Wittwer Jost , Rumpf Alexander , Weller Bernhard
Published: September 2022

Der Beitrag geht auf ausgewählte Ergebnisse des Forschungsvorhabens PRINTGLASS ein. Dieses Vorhaben widmet sich einer neuen Art der Randbedruckung. Die Randbedruckung wird im Digital‐druckverfahren direkt auf Glas oder auf ausgesuchten Sonnenschutzbeschichtungen ausgeführt. Der Einsatz der Digitalbedruckung als Haftgrund wurde durch eine neue Farbzusammensetzung und umfangreiche Untersuchungen möglich. Neben Untersuchungen an den digital bedruckten Oberflächen werden auch Ergebnisse zur Biegezugfestigkeit vorgestellt. Zusätzlich wurde das Haftvermögen verschiedener elastischer Dicht‐ und Klebstoffe im ungealterten und gealterten Zustand analysiert. Abschließend stellt der Beitrag noch die Dauerhaftigkeitsversuche an verschiedenen Isoliergläsern vor.

Edge seal of insulating glass units on coated and digitally printed glass surfaces. The paper discusses selected results of the PRINTGLASS research project. This project is dedicated to a new type of edge printing. The edge printing is carried out in a digital printing process directly on glass or on selected sun protection coatings. The use of digital printing as a substrate was made possible thanks to a new ink composition and extensive research. In addition to tests on the digitally printed surfaces, results on bending tensile strength are also presented. In addition, the adhesion of various elastic sealants and adhesives in the unaged and aged state was analysed. Finally, the paper presents durability tests on various insulating glass units.
Towards Substrate–Reagent Interaction of Lochmann–Schlosser Bases in THF: Bridging THF Hides Potential Reaction Site of a Chiral Superbase
Authors: Brieger Lukas , Schrimpf Tobias , Scheel Rebecca , Unkelbach Christian , Strohmann Carsten
Published: September 2022

The metalation of N,N‐dimethylaminomethylferrocene in THF by the superbasic mixture of nBuLi/KOtBu proceeds readily at low temperatures to afford a bimetallic Li2K2 aggregate containing ferrocenyl anions and tert‐butoxide. Starting from an enantiomerically enriched ortho‐lithiated aminomethylferrocene, an enantiomerically pure superbase can be prepared. The molecular compound exhibits superbasic behavior deprotonating N,N‐dimethylbenzylamine in the α‐position and is also capable of deprotonating toluene. Quantum chemical calculations provide insight into the role of the bridging THF molecule to the possible substrate–reagent interaction. In addition, a benzylpotassium alkoxide adduct gives a closer look into the corresponding reaction site of the Lochmann–Schlosser base that is reported herein.
Using Numerical Dissipation Rate and Viscosity to Assess Turbulence‐Related Data Accuracy – Part 2: Results
Authors: Turek Vojtěch , Jegla Zdeněk , Dohnal Miloslav , Reppich Marcus
Published: September 2022

This is the second part of a two‐part paper focusing on the assessment of accuracy of turbulence‐related data from CFD simulations using effective numerical dissipation rate and effective numerical viscosity. Experimental setup has been discussed in the first part of this series. Here, the relevant solution data obtained via CFD are compared to the values from laser Doppler anemometry measurements, and it is studied whether the accuracy of such data can be assessed using the two mentioned quantities. The overall outcome is that although judging mesh quality generally is possible, alone the two quantities are insufficient to draw conclusions regarding the actual solution data.
Knowledge creation capability and the impact on innovation performance in global consulting firms: The role of human and social capital
Authors: Rhee Yang Pok , Park Chansoo , Cooper Tom
Published: September 2022

The purpose of this study is to identify the relationships between knowledge creation capability and innovation performance in multinational consulting organizations. We introduce two important but conceptually distinct, intellectual attribute constructs—human and social capital—as mechanisms that moderate the relationship. Survey data from 172 professional consultants in subsidiaries of multinational management consulting firms was empirically analyzed. This study confirms the importance of tacit knowledge creation capability for innovation and finds that explicit knowledge creation does not have substantial effects on innovation performance. Human capital has negative moderating effects on how tacit knowledge creation influences innovation performance, but it has a positive moderating effect on the relationship between explicit knowledge creation and innovation. The negative moderating effect of human capital appears stronger in the senior consultant groups. On the other hand, social capital has no moderating effects on knowledge creation capability and innovation. These results provide managerial implications for global subsidiaries' knowledge‐creating capabilities as drivers of successful, innovative change.
Improving access to oncology publications for advocates and people with cancer
Authors: Tabernero Josep , Bowling Tami Eagle , Rivers Jamil , Chari Dheepa , Ghith Jennifer , Ferdinand Roxanne , Shanahan Kelly , Shore Neal D.
Published: September 2022

Lay summary

Journal articles provide reliable and current information about cancer research.

This can offer hope to people with cancer and help them make decisions about their care.

Here, the authors suggest ways in which different groups may help people with cancer to find, view, and understand articles.

For example, journals should make articles free to view if they describe research that could change patient care.

Also, clear titles and easy‐to‐follow summaries or videos may help people to find relevant articles and understand the main findings.

It is important to explore ways to best share research with all those whose lives it may affect.