bluuebunny/crossref_metadata_2025 huggingface dataset:
Correct(ed) Klett–Fernald algorithm for elastic aerosol backscatter
retrievals: a sensitivity analysis
Authors: Speidel Johannes , Vogelmann Hannes
Published: January 2023

Retrieval algorithms for
aerosol elastic backscatter lidars are most commonly based on a signal
inversion known as the Klett solution. While often used, a sign error
in the original publication has barely been mentioned or recognized in
the scientific community. In this study, we present a corrected Klett
inversion and a sensitivity analysis of its implementation under
different atmospheric conditions. We show that the error’s dimension
depends on multiple factors, thus preventing trivial a posteriori corrections on the results
calculated with the original, uncorrected Klett solution. Comparing
the uncorrected with the corrected Klett solution, long integration
pathways in combination with low aerosol concentrations lead to
substantial relative deviations of more than 100%, whereas short
integration pathways with high aerosol concentrations considerably
reduce the relative deviations to magnitudes around 15%. The higher
the altitude of layers with increased aerosol concentrations, the
higher the deviations due to the incorrect usage of Klett’s inversion,
however on a slight level ().
Filter design and color correction for the X-cube prism 3CCD camera
Authors: Chen Suhao , Lü Bo , Wu Xiaotian , Liu Weiqi , Lü Qipeng
Published: January 2023

For the

X

-cube prism three-charge-coupled-device (3CCD) camera, the spectra of the designed dichroic films in the

X

-cube prism shift with changes in the angle of incident light, producing non-uniformity of color on the image plane. We considered the influence of the incident angle on color performance in filter design and directly optimized the thin film to improve color consistency. An optical model was constructed to calculate the distribution of camera spectral sensitivity and independently correct the non-uniform color on the image plane. Results showed that the optimization and correction methods could significantly improve the color performance of the

X

-cube prism 3CCD camera.
Process optimization of contact hole patterns via a simulated annealing algorithm in extreme ultraviolet lithography
Authors: Zhao Rongbo , Wei Yayi , Xu Hong , He Xiangming
Published: January 2023

The critical dimension (CD), roughness, and sensitivity are extremely significant indicators for evaluating the imaging performance of photoresists in extreme ultraviolet lithography. As the CD gradually shrinks, tighter indicator control is required for high fidelity imaging. However, current research primarily focuses on the optimization of one indicator of one-dimensional line patterns, and little attention has been paid to two-dimensional patterns. Here, we report an image quality optimization method of two-dimensional contact holes. This method takes horizontal and vertical contact widths, contact edge roughness, and sensitivity as evaluation indicators, and uses machine learning to establish the corresponding relationship between process parameters and each indicator. Then, the simulated annealing algorithm is applied to search for the optimal process parameters, and finally, a set of process parameters with optimum image quality is obtained. Rigorous imaging results of lithography demonstrate that this method has very high optimization accuracy and can improve the overall performance of the device, dramatically accelerating the development of the lithography process.
Optimization of bulk sensitivity for strip, slot, and subwavelength grating-based waveguides for dual-polarization operation
Authors: Ozcan Can , Aitchison J. Stewart , Mojahedi Mo
Published: January 2023

We propose a dual-polarization optimization method for the bulk sensitivity of silicon-on-insulator (SOI) waveguides by defining a multi-objective function that accounts for the substrate leakage losses. The proposed optimization method was used to design micro-ring resonator bulk sensors with strip, slot, subwavelength grating, and subwavelength grating slot waveguides. The subwavelength grating slot waveguide has a bulk sensitivity of 520 nm/RIU and 325 nm/RIU for the TE and TM modes, respectively, both of which are higher than the bulk sensitivities of strip, slot, and subwavelength grating waveguides. Moreover, our Monte Carlo analysis shows that the subwavelength grating slot waveguide has the highest immunity to fabrication errors.
Deep-sequencing of viral genomes from a large and diverse cohort of treatment-naive HIV-infected persons shows associations between intrahost genetic diversity and viral load
Authors: Gabrielaite Migle , Bennedbæk Marc , Rasmussen Malthe Sebro , Kan Virginia , Furrer Hansjakob , Flisiak Robert , Losso Marcelo , Lundgren Jens D. ,   INSIGHT START Study Group, Marvig Rasmus L.
Published: January 2023

Background

Infection with human immunodeficiency virus type 1 (HIV) typically results from transmission of a small and genetically uniform viral population. Following transmission, the virus population becomes more diverse because of recombination and acquired mutations through genetic drift and selection. Viral intrahost genetic diversity remains a major obstacle to the cure of HIV; however, the association between intrahost diversity and disease progression markers has not been investigated in large and diverse cohorts for which the majority of the genome has been deep-sequenced. Viral load (VL) is a key progression marker and understanding of its relationship to viral intrahost genetic diversity could help design future strategies for HIV monitoring and treatment.

Methods

We analysed deep-sequenced viral genomes from 2,650 treatment-naive HIV-infected persons to measure the intrahost genetic diversity of 2,447 genomic codon positions as calculated by Shannon entropy. We tested for associations between VL and amino acid (AA) entropy accounting for sex, age, race, duration of infection, and HIV population structure.

Results

We confirmed that the intrahost genetic diversity is highest in the env gene. Furthermore, we showed that mean Shannon entropy is significantly associated with VL, especially in infections of >24 months duration. We identified 16 significant associations between VL (p-value<2.0x10-5) and Shannon entropy at AA positions which in our association analysis explained 13% of the variance in VL. Finally, equivalent analysis based on variation in HIV consensus sequences explained only 2% of VL variance.

Conclusions

Our results elucidate that viral intrahost genetic diversity is associated with VL and could be used as a better disease progression marker than HIV consensus sequence variants, especially in infections of longer duration. We emphasize that viral intrahost diversity should be considered when studying viral genomes and infection outcomes.

Trial registration

Samples included in this study were derived from participants who consented in the clinical trial, START (NCT00867048) (23), run by the International Network for Strategic Initiatives in Global HIV Trials (INSIGHT). All the participant sites are listed here: http://www.insight-trials.org/start/my_phpscript/participating.php?by=site
Neutral vs. non-neutral genetic footprints of Plasmodium falciparum multiclonal infections
Authors: Labbé Frédéric , He Qixin , Zhan Qi , Tiedje Kathryn E. , Argyropoulos Dionne C. , Tan Mun Hua , Ghansah Anita , Day Karen P. , Pascual Mercedes
Published: January 2023

At a time when effective tools for monitoring malaria control and eradication efforts are crucial, the increasing availability of molecular data motivates their application to epidemiology. The multiplicity of infection (MOI), defined as the number of genetically distinct parasite strains co-infecting a host, is one key epidemiological parameter for evaluating malaria interventions. Estimating MOI remains a challenge for high-transmission settings where individuals typically carry multiple co-occurring infections. Several quantitative approaches have been developed to estimate MOI, including two cost-effective ones relying on molecular data: i) THE REAL McCOIL method is based on putatively neutral single nucleotide polymorphism loci, and ii) the varcoding method is a fingerprinting approach that relies on the diversity and limited repertoire overlap of the var multigene family encoding the major Plasmodium falciparum blood-stage antigen PfEMP1 and is therefore under selection. In this study, we assess the robustness of the MOI estimates generated with these two approaches by simulating P. falciparum malaria dynamics under three transmission conditions using an extension of a previously developed stochastic agent-based model. We demonstrate that these approaches are complementary and best considered across distinct transmission intensities. While varcoding can underestimate MOI, it allows robust estimation, especially under high transmission where repertoire overlap is extremely limited from frequency-dependent selection. In contrast, THE REAL McCOIL often considerably overestimates MOI, but still provides reasonable estimates for low and moderate transmission. Regardless of transmission intensity, results for THE REAL McCOIL indicate that an inaccurate tail at high MOI values is generated, and that at high transmission, an apparently reasonable estimated MOI distribution can arise from some degree of compensation between overestimation and underestimation. As many countries pursue malaria elimination targets, defining the most suitable approach to estimate MOI based on sample size and local transmission intensity is highly recommended for monitoring the impact of intervention programs.
Effect of adipose derived stromal vascular fraction on leprosy neuropathy: A Preliminary report
Authors: Sirait Sondang P. , Bramono Kusmarinah , Menaldi Sri Linuwih , Pawitan Jeanne Adiwinata , Indriatmi Wresti , Aninditha Tiara
Published: January 2023

Background

Adipose derived stromal vascular fraction (SVF) contains a heterogeneous population of mononuclear cells, progenitor cells and about 1–10% are mesenchymal stromal cells. These cells are an ideal candidate for regenerative medicine for peripheral neuropathy. Leprosy is a disabling disorder with neuropathy, usually with consequences of permanent disability of the extremities. We conducted a preliminary study to evaluate the cell yield, its characteristics and clinical outcomes after SVF injections in four leprosy patients.

Methods

Four post leprosy patients were recruited and evaluated for sensory testing (warm detection, cold detection, vibration, pain and sensation) on the ulnar area of the hand. Liposuction was done and adipose tissue was processed into SVF with a closed system and injected to the ulnar area of the hand at the dorsal and palmar side. Evaluation of sensory testing was done after 3 days, 1 week, 1 month and 3 months following SVF injection. SVF was also characterized using flow cytometry, cell counting, sterility and presence of mycobacteria.

Results

The results showed that leprosy patients had a low count of mesenchymal cells and a high amount of CD34/CD45 positive cells. One patient was positive for mycobacteria from his adipose tissue and SVF. Sensory examination after SVF injection showed an improvement in temperature and pain sensation in the palmar and superficial branch. Meanwhile, touch sensation improved on the dorsal branch, and there was no improvement for vibration in all patients.

Conclusions

The results showed that SVF had a potential to improve sensory loss in leprosy patients.
Longitudinal proteomic profiling of the inflammatory response in dengue patients
Authors: Garishah Fadel Muhammad , Boahen Collins K. , Vadaq Nadira , Pramudo Setyo G. , Tunjungputri Rahajeng N. , Riswari Silvita Fitri , van Rij Ronald P. , Alisjahbana Bachti , Gasem Muhammad Hussein , van der Ven André J. A. M. , de Mast Quirijn
Published: January 2023

Background

The immunopathogenesis of dengue virus (DENV) infection remains incompletely understood. To increase our understanding of inflammatory response in non-severe dengue, we assessed longitudinal changes in the inflammatory proteome in patients with an acute DENV infection.

Methods

Using a multiplex proximity extension assay (PEA), we measured relative levels of 368 inflammatory markers in plasma samples from hospitalized patients with non-severe DENV infection in the acute (n = 43) and convalescence (n = 35) phase of the infection and samples of healthy controls (n = 10).

Results

We identified 203 upregulated and 39 downregulated proteins in acute versus convalescent plasma samples. The upregulated proteins had a strong representation of interferon (IFN) and IFN-inducible effector proteins, cytokines (e.g. IL-10, IL-33) and cytokine receptors, chemokines, pro-apoptotic proteins (e.g. granzymes) and endothelial markers. A number of differentially expressed proteins (DEPs) have not been reported in previous studies. Functional network analysis highlighted a central role for IFNγ, IL-10, IL-33 and chemokines. We identified different novel associations between inflammatory proteins and circulating concentrations of the endothelial glycocalyx disruption surrogate marker syndecan-1.

Conclusion: This unbiased proteome analysis provides a comprehensive insight in the inflammatory response in DENV infection and its association with glycocalyx disruption.
Impact of the COVID-19 pandemic and multiplex polymerase chain reaction test on outpatient antibiotic prescriptions for pediatric respiratory infection
Authors: Kitagawa Daisuke , Kitano Taito , Furumori Madoka , Suzuki Soma , Shintani Yui , Nishikawa Hiroki , Suzuki Rika , Yamamoto Naohiro , Onaka Masayuki , Nishiyama Atsuko , Kasamatsu Takehito , Shiraishi Naoyuki , Suzuki Yuki , Nakano Akiyo , Nakano Ryuichi , Yano Hisakazu , Maeda Koichi , Yoshida Sayaka , Nakamura Fumihiko
Published: January 2023

This study aimed to evaluate the impact of the prolonged COVID-19 pandemic on outpatient antibiotic prescriptions for pediatric respiratory infections at an acute care hospital in Japan in order to direct future pediatric outpatient antibiotic stewardship. The impact of the COVID-19 pandemic and the FilmArray Respiratory Panel (RP) on outpatient antibiotic prescriptions was assessed from January 2019 to December 2021 using an interrupted time series analysis of children <20 years. The overall antimicrobial prescription rate decreased from 38.7% to 22.4% from the pre-pandemic period to the pandemic. The pandemic (relative risk [RR] level, 0.97 [0.58–1.61]; P = 0.90; RR slope, 1.05 [0.95–1.17] per month; P = 0.310) and FilmArray RP (RR level, 0.90 [0.46–1.75]; P = 0.75; RR slope, 0.95 [0.85–1.06] per month; P = 0.330) had no significant effect on the monthly antibiotic prescription rates. The COVID-19 pandemic was not significantly related to the antibiotic prescription rate, suggesting that it did not impact physicians’ behavior toward antibiotic prescriptions. Replacing rapid antigen tests with the FilmArray RP introduced on December 1, 2020, did not affect the magnitude of the reduction in antibiotic prescription rate for pediatric respiratory infections.
The continued effects of COVID-19 on the lives and livelihoods of vegetable farmers in India
Authors: Kumar Sandhya S. , Schreinemachers Pepijn , Pal Arshad Ahmad , Manickam Ravishankar , Nair Ramakrishnan M. , Srinivasan Ramasamy , Harris Jody
Published: January 2023

India experienced a rapid rise in COVID-19 infections from March 2021. States imposed varying levels of lockdowns and curfews to curb the spread of the disease. These restrictions severely affected the functioning of food systems. The objective of this study was to analyze how COVID-19 continues to affect agricultural production, food security and household diets of vegetable farmers. A phone-based survey was conducted with 595 vegetable farmers in the states of Andhra Pradesh, Assam, Jharkhand, Karnataka and Odisha, 60% of whom had been interviewed a year earlier. Overall, 60% of farmers experienced decreased vegetable production; over 80% reported a reduction in consumption of at least one food group; and 45% reported some level of food insecurity between May 2020 and May 2021. Farmers who reported decreased staples production, difficulty accessing seeds/seedlings, or reduced their household spending were more likely to report decreased vegetable production. Vegetable consumption was positively associated with receipt of COVID-19 relief benefits, borrowing money, or having home gardens. Farmers who received public agricultural assistance, or had reduced expenses, were more likely to have lower vegetable consumption. Greater severity of food insecurity was associated with farmers belonging to underprivileged social groups, non-Hindus, or those who experienced decrease in livestock production, weather related disruptions or received COVID-19 assistance. This is one of few studies that have conducted a longitudinal assessment of the impacts across multiple waves of COVID-19. COVID-19 is seen to be one among several shocks experienced by farm households, and exacerbated existing issues within agriculture and food security. There is a need for public policy support to strengthen both production and consumption of vegetables.
Confidence intervals and sample size planning for optimal cutpoints
Authors: Thiele Christian , Hirschfeld Gerrit
Published: January 2023

Various methods are available to determine optimal cutpoints for diagnostic measures. Unfortunately, many authors fail to report the precision at which these optimal cutpoints are being estimated and use sample sizes that are not suitable to achieve an adequate precision. The aim of the present study is to evaluate methods to estimate the variance of cutpoint estimations based on published descriptive statistics (‘post-hoc’) and to discuss sample size planning for estimating cutpoints. We performed a simulation study using widely-used methods to optimize the Youden index (empirical, normal, and transformed normal method) and three methods to determine confidence intervals (the delta method, the parametric bootstrap, and the nonparametric bootstrap). We found that both the delta method and the parametric bootstrap are suitable for post-hoc calculation of confidence intervals, depending on the sample size, the distribution of marker values, and the correctness of model assumptions. On average, the parametric bootstrap in combination with normal-theory-based cutpoint estimation has the best coverage. The delta method performs very well for normally distributed data, except in small samples, and is computationally more efficient. Obviously, not every combination of distributions, cutpoint optimization methods, and optimized metrics can be simulated and a lot of the literature is concerned specifically with cutpoints and confidence intervals for the Youden index. This complicates sample size planning for studies that estimate optimal cutpoints. As a practical tool, we introduce a web-application that allows for running simulations of width and coverage of confidence intervals using the percentile bootstrap with various distributions and cutpoint optimization methods.
Influence of subway train fire locations on the characteristics of smoke movement in a curved tunnel
Authors: Zhou Dan , Li Jinzhu , Hu Tianen , Chen Tao
Published: January 2023

Scenario models of a moving subway train can help investigate the influence of different fire locations on smoke propagation characteristics in curved tunnels. To this end, this study adopts the three-dimensional Unsteady Reynolds Average Navier-Stokes equations method and the renormalization group k-ε two-equation turbulence model with buoyancy correction for numerical analysis. The motion of the train is replicated using the slip grid technique. The results indicate that when a fire breaks out on a moving train in tunnels, the piston wind leads the longitudinal movement of the smoke. If a fire erupts in the head or middle car of a moving train, the time of smoke backflow is delayed by 30 s or 17 s, respectively, compared to that for the tail car. The obtained results provide a theoretical basis for reasonably controlling the smoke flow in subway tunnels and reducing casualties in fire accidents.
Investigating water movements around a shallow shipwreck in Big Tub Harbour of Lake Huron: Implications for managing and preserving underwater shipwrecks
Authors: Flood Bryan , Girihagama Lakshika , Wells Mathew G. , Valipour Reza , Semcesen Patricia , Parker Scott
Published: January 2023

The Sweepstakes, in Fathom Five National Marine Park, is Ontario’s most iconic shipwreck with over 100,000 visitors each summer. Continued exposure to water currents has directly and indirectly affected the integrity of the wreck and resulted in management interventions including efforts to stabilize the wreck and control vessel activity (both duration and speed). Despite these efforts, a scour ring is present in the sediment around the Sweepstakes, raising concerns regarding the prolonged stability of the wreck. An extensive series of field measurements were made during the summer of 2015 with the aim of differentiating between natural hydrological processes present at this site and human-derived water movements during the summer visitor season. There is a high-degree of natural current variability from processes as diverse as wind-induced surface gravity waves, internal gravity waves, and diurnal flows due to differential heating. Our results show that summer circulation driven by internal gravity waves derived from upwelling, surface waves, and differential heating was insignificant with respect to sediment resuspension and thus unlikely to produce the observed scour around the shipwreck. Scour is most likely caused by energetic winter storms, which should be a focus of future studies. While vessel induced currents were detectable at the shipwreck, they were no larger than the normal summer hydrodynamic variability, thus suggesting that management efforts continue to protect the site generally.
Psychometric properties of the Social Support Scale (SSS) in two Aboriginal samples
Authors: Santiago Pedro Henrique Ribeiro , Smithers Lisa Gaye , Roberts Rachel , Jamieson Lisa
Published: January 2023

In Australia, despite social support increasingly being reported as playing an important role in influencing health outcomes of Aboriginal and Torres Strait Islanders, measures of social support have not yet been validated for Aboriginal people. The current study aimed to evaluate the validity and reliability of the Social Support Scale in an Aboriginal and/or Torres Strait Islander population. The Social Support Scale (SSS) is a 4-item psychological instrument that was designed to evaluate four social support functions, instrumental, informational, emotional and appraisal support. Data included participants from two different samples: (1) Teeth Talk Study (n = 317), an oral-health randomized controlled trial (RCT) conducted with Aboriginal adults; and (2) the South Australian Aboriginal Birth Cohort Study (n = 367), a prospective longitudinal birth cohort study in which pregnant Aboriginal women were interviewed at baseline. The SSS psychometric properties were examined with Graphical Loglinear Rasch Models (GLLRM). The overall fit to a GLLRM was established (χ2(96)sample1= 52.7, p = 0.06; χ2(25)sample2= 22.2, p = 0.62) after accounting for local dependence between items 3 and 4. Item 2 displayed differential item functioning by employment status in Sample 1. Regarding dimensionality, the SSS was unidimensional in both samples (γobs1= 0.80; γexp1= 0.78, p = 0.65; γobs2= 0.75, γexp2= 0.77, p = 0.16). The instrument also displayed good reliability (Rsample1= 0.82, Rsample2= 0.84). Despite a few identified limitations (such as poor targeting), the findings indicated that the SSS is a promising instrument to provide culturally-valid and reliable measurement of social support among Aboriginal and/or Torres Strait Islander adults. Future studies should further investigate the instrument psychometric properties in other Aboriginal samples and the development and inclusion of culturally-sensitive items are also recommended.
Mapping hematologists’ HIV testing behavior among lymphoma patients–A mixed-methods study
Authors: Bogers Saskia , Zimmermann Hanne , Ndong Amie , Davidovich Udi , Kersten Marie José , Reiss Peter , Schim van der Loeff Maarten , Geerlings Suzanne ,   on behalf of the HIV Transmission Elimination AMsterdam (H-TEAM) Consortium
Published: January 2023

Background

HIV testing among patients with malignant lymphoma (PWML) is variably implemented. We evaluated HIV testing among PWML, and mapped factors influencing hematologists’ testing behavior.

Materials

We conducted a mixed-methods study assessing HIV testing among PWML, factors influencing HIV testing and opportunities for improvement in five hospitals in the region of Amsterdam, the Netherlands. The proportion of PWML tested for HIV within 3 months before or after lymphoma diagnosis and percentage positive were assessed from January 2015 through June 2020. Questionnaires on intention, behavior and psychosocial determinants for HIV testing were conducted among hematologists. Through twelve semi-structured interviews among hematologists and authors of hematology guidelines, we further explored influencing factors and opportunities for improvement.

Findings

Overall, 1,612 PWML were included for analysis, including 976 patients newly diagnosed and 636 patients who were referred or with progressive/relapsed lymphoma. Seventy percent (678/976) of patients newly diagnosed and 54% (343/636) of patients with known lymphoma were tested for HIV. Overall, 7/1,021 (0.7%) PWML tested HIV positive, exceeding the 0.1% cost-effectiveness threshold. Questionnaires were completed by 40/77 invited hematologists, and 85% reported intention to test PWML for HIV. In the interviews, hematologists reported varying HIV testing strategies, including testing all PWML or only when lymphoma treatment is required. Recommendations for improved HIV testing included guideline adaptations, providing electronic reminders and monitoring and increasing awareness.

Conclusions

Missed opportunities for HIV testing among PWML occurred and HIV test strategies varied among hematologists. Efforts to improve HIV testing among PWML should include a combination of approaches.
Gene silencing for invasive paper wasp management: Synthesized dsRNA can modify gene expression but did not affect mortality
Authors: Bulgarella Mariana , Baty James W. , McGruddy Rose , Lester Philip J.
Published: January 2023

Invasive paper wasps such as Polistes dominula are a major pest and problem for biodiversity around the globe. Safe and highly targeted methods for the control of these and other social wasp populations are needed. We attempted to identify potentially-lethal gene targets that could be used on adult paper wasps in a gene silencing or RNA interference (RNAi) approach. Double-stranded RNA (dsRNA) was designed to target genes for which silencing has proven lethal in other insects. dsRNA was provided either orally to foragers or directly injected into the wasps. We also provided the dsRNA unprotected or protected from degradation by gut nucleases in two different forms (lipofectamine and carbon quantum dots). The effects of oral delivery of 22 different gene targets to forager wasps was evaluated. The expression of five different genes was successfully reduced following dsRNA ingestion or injection. These gene targets included the FACT complex subunit spt16 (DRE4) and RNA-binding protein fusilli (FUSILLI), both of which have been previously shown to have potential as lethal targets for pest control in other insects. However, we found no evidence of significant increases in adult wasp mortality following ingestion or injection of dsRNA for these genes when compared with control treatments in our experiments. The methods we used to protect the dsRNA from digestive degradation altered gene expression but similarly did not influence wasp mortality. Our results indicate that while many of the same gene targets can be silenced and induce mortality in other insects, dsRNA and RNAi approaches may not be useful for paper wasp control.
Resenha de Leão, D.; Guerrier, O. (eds.). Figures de sages, figures de philosophes dans l'oeuvre de Plutarque (2019)
Authors: De Oliveira Silva Maria Aparecida
Published: January 2023

Resenha de Leão, D.; Guerrier, O. (eds.). Figures de sages, figures de philosophes dans l'oeuvre de Plutarque (2019)
Resenha de Cassin, B. Quand dire, c’est vraiment faire. Homère, Gorgias et le peuple arc-en-ciel. Paris: Fayard, 2018.
Authors: Cardim Leandro
Published: January 2023

Resenha de Cassin, B. Quand dire, c’est vraiment faire. Homère, Gorgias et le peuple arc-en-ciel. Paris: Fayard, 2018.
“Todos los hombres nacen aristotélicos o platónicos”. Borges entre Platón y Aristóteles
Authors: Soares Lucas
Published: January 2023

La frase del poeta inglés Samuel Taylor Coleridge, “todos los hombres nacen aristotélicos o platónicos”, traída a colación por Borges en diversas ocasiones, es harto conocida y citada. Pero lo que a mi modo de ver no ha sido tan explorado es el sentido que la disyunción implicada en dicha frase asume en la obra borgeana. Analizar cómo juega en ella tal disyunción entre Platón y Aristóteles, a la luz de las referencias que Borges hace de ellos a lo largo de su obra, es el propósito de este trabajo. Para ello me interesa relevar algunos motivos platónicos y aristotélicos empleados por aquel en función de su universo ficcional, a fin de evaluar el sentido y alcance de dicha disyunción. Mi hipótesis es que ella asume en la obra de Borges un sentido débil e incluyente, que posiciona a este autor en una vía entre Platón y Aristóteles.
Recensione a Maddalena Bonelli (a cura di). Filosofe Maestre Imperatrici. Per un nuovo canone della storia della filosofia antica (2020)
Authors: Palumbo Lidia
Published: January 2023

Recensione a Maddalena Bonelli (a cura di). (2020) Filosofe Maestre Imperatrici. Per un nuovo canone della storia della filosofia antica. Roma, Edizioni di Storia e letteratura.
Numenio interprete del Timeo. Note sull’ esegesi del verbo βλέπω (frr. 11, 12, 18 Des Places)
Authors: Volpe Enrico
Published: January 2023

Numenio appartiene all’ambito degli interpreti medioplatonici dei dialoghi di Platone; nel Medioplatonismo, infatti, si diffuse la tendenza a interpretare la filosofia di Platone come in chiave sistematica. Il dialogo più rilevante per questa operazione esegetica nel Medioplatonismo fu certamente il Timeo. In questo contributo intendo concentrarmi sull’interpretazione delle pagine 28a-29a del Timeo da parte di Numenio di Apamea ed esaminarne l’esegesi alla luce della sua prospettiva onto-teologica. Nel Timeo, l’utilizzo del verbo βλέπω ha la funzione di descrivere il fatto che il demiurgo è contemplativo nei confronti del paradigma intelligibile. In Numenio, invece, l’associazione del verbo βλέπω al demiurgo è volta a mostrare il ruolo di mediatore che il secondo dio svolge tra il primo principio e la materia. In questo modo si mostrerà come i passi del Timeo vengano interpretati da Numenio alla luce della sua metafisica dualista.
Predictors of heart failure in children with congenital heart disease
Authors: Nora Meily Elven , Murni Indah Kartika , Nugroho Sasmito , Noormanto Noormanto
Published: January 2023

Background Heart failure continues to be a significant contributor to morbidity and mortality in children with congenital heart disease (CHD). Little is known about heart failure in children. Identifying predictors of heart failure in children with CHD can serve to guide preventive strategies to heart failure.
Objective To understand the predictors of heart failure of children with congenital heart disease.
Methods A nested, case-control study was performed using secondary data based on a prospective study previously conducted in Dr Sardjito Tertiary Hospital in Yogyakarta in years 2011-2013. We included children aged 1 month-18 years who had been diagnosed with CHD by echocardiography. Age, sex, type of CHD, CHD complexity, as well as presence of syndrome, no pulmonary obstruction, pneumonia, and malnutrition were analyzed as potential predictors of heart failure. Results are presented as odds ratios (OR) with 95% confidence intervals (95%CI).
Results A total of 2,646 children were hospitalized in Dr Sardjito Tertiary Hospital during the study period. Congenital heart disease was noted in 216 children (8.16%), 200 (7.5%) of whom met the inclusion criteria. The 100 children with heart failure had median age of 1.5 years and 15% died during hospitalization. Multivariate analysis revealed that acyanotic CHD (OR 2.69; 95%CI 1.45 to 5.00), no pulmonary obstruction (OR 3.05; 95%CI 1.33 to 6.99) and the presence of pneumonia (OR 2.04; 95%CI 1.03 to 4.06) were statistically significant as independent predictors of heart failure in children with CHD. However, sex, age, CHD complexity, as well as presence of a syndrome, and malnutrition were not significantly associated with heart failure in children with CHD.
Conclusion The predictors of heart failure in children with CHD were acyanotic CHD, no pulmonary obstruction, and presence of pneumonia.
Hubungan pH Feses sebagai Prediktor Disbiosis Mikrobiota Usus dengan Stunting pada Batita
Authors: Setiowati Irizki Tisna , Nugroho Hari Wahyu , Widiretnani Septin
Published: January 2023

Latar belakang. Stunting masih menjadi permasalahan utama kesehatan anak. Intervensi pada periode 1.000 hari pertama kehidupan penting untuk mencegah stunting. Stunting berkaitan dengan disbiosis mikrobiota usus yang masih menjadi hal menarik dan perlu untuk diteliti. Perubahan komposisi mikrobiota usus tergambar dari keadaan pH feses.Tujuan. Mengetahui hubungan pH feses sebagai prediktor disbiosis mikrobiota usus dengan stunting pada Batita. Metode. Penelitian ini menggunakan desain potong lintang dalam uji prognostik. Pengambilan sampel dilakukan secara consecutive sampling pada Batita yang mengikuti kegiatan Posyandu di Kecamatan Jaten, Kabupaten Karanganyar, Jawa Tengah pada Februari 2021 – Juli 2021. Data dianalisis menggunakan koefisien kontingensi dan regresi logistik, tingkat kemaknaan hasil uji ditentukan berdasarkan nilai p<0,05.Hasil. Dari 55 subjek neonatus, didapatkan 15 subjek dengan stunting. Sembilan dari 15 subjek stunting memiliki pH feses lebih tinggi signifikan dibandingkan dengan Batita normal, yakni ?6,41 (p<0,001). Nilai cut off didapatkan untuk pH feses adalah 6,41 dengan sensitivitas 60%, spesifisitas 95%, dan odd ratio (OR) 28,50; (IK 95% 4,915-165,245).Kesimpulan. Terdapat hubungan pH feses sebagai prediktor disbiosis mikrobiota usus dengan stunting pada Batita.
Pengaruh Pemberian Hindmilk Air Susu Ibu pada Status Gizi Bayi Berat Lahir Rendah
Authors: Nugraheni Zenny , Salimo Harsono , Kartikasari Lilik Retna , Wandita Setya
Published: January 2023

Latar belakang. Air susu ibu eksklusif dianjurkan diberikan pada bayi berat lahir rendah (BBLR), tetapi pertambahan berat badannya sering tidak memadai. Hindmilk merupakan bagian air susu ibu (ASI) yang mengandung kalori dan lemak tinggi. Tujuan. Untuk mengetahui apakah pemberian hindmilk meningkatkan status gizi yang lebih baik daripada ASI standard. Metode. Penelitian Randomized Control Trial dilakukan di unit perawatan neonatus antara Februari-Mei 2022. Kriteria inklusi adalah bayi dengan berat lahir 1000-2000 gram yang berumur 0-30 hari, sudah minum penuh ASI eksklusif,  dan payudara ibu mampu memroduksi ASI minimal 200 mL/hari. Kriteria eksklusi adalah bayi dengan kelainan bawaan, gangguan metabolik, ibu COVID-19, atau ada kontra-indikasi pemberian ASI. Subjek yang sesuai kriteria inklusi dan eksklui dirandom dengan cara blok untuk dimasukkan dalam kelompok perlakuan (hindmilk) atau kontrol (ASI standard).Hasil. Terdapat 54 subjek yang masuk penelitian yang terbagi pada kelompok hindmilk (28 subjek) dan kelompok ASI standard (26 subjek). Penurunan status gizi sangat kurus pada kelompok hindmilk ASI lebih banyak daripada ASI standard (71,42% vs 57,69%). Peningkatan status gizi lebih baik pada kelompok hindmilk (p=0,019).Kesimpulan. Peningkatan status gizi pada BBLR yang diberi hindmilk lebih baik daripada ASI standar.Tujuan: untuk menganalisis pengaruh pemberian hindmilk ASI terhadap peningkatan status gizi dan lama rawat bayi terhadap berat badan lahir rendah dan sangat rendah.Metode: Penelitian ini merupakan penelitian Eksperimental Randomized Control Trial dengan rancangan pre posttest with control group desain. Pengambilan sampel dilakukan secara consecutive sampling yang dilakukan pada bulan Februari-Mei 2022 di Ruang Perinatal RSUP Dr. Sardjito Yogyakarta. Subjek penelitian ada 54 Bayi Berat Lahir Rendah (BBLR) 1000-2000g. Pengamatan dilakukan mulai bayi masuk dirawat, fullfeeding sampai dengan diperbolehkan pulang.Hasil: Penelitian ini menunjukkan adanya peningkatan berat badan dan status gizi secara signifikan pada BBLR 1000-2000g yang diberikan hindmilk ASI (p=0,019 < 0,05). Penurunan status gizi sangat kurus pada BBLR 1000-2000g yang diberikan hindmilk ASI dari 71,42% (20 BBLR) menjadi 7,14% (2 BBLR) dan mix ASI dari 57,69% (15 BBLR) menjadi 30,77% (8 BBLR). Sementara itu tidak ada perbedaan yang bermakna pada lama rawat inap BBLR 1000-2000g yang diberikan hindmilk ASI dan mix (foremilk dan hindmilk) dengan rata-rata lama rawat 22 hari dan 20 hari (p= 0,370 > 0,05). Lama rawat inap dapat dipengaruhi oleh morbiditas dan gejala pada BBLR.Kesimpulan: Hindmilk ASI secara signifikan dapat meningkatkan status gizi BBLR 1000-2000g. Tidak ada perbedaan secara signifikan lama rawat BBLR 1000-2000g yang diberikan hindmilk dan mix (foremilk dan hindmilk) ASI. Perlu penelitian lebih lanjut untuk melihat umur kehamilan, gejala dan morbiditas BBLR.
Two Articles by Ber Borokhov about Judaica Libraries and Librarians
Authors: Baker Zachary M.
Published: January 2023

Two translated articles published by Ber Borokhov (1881–1917) in the Yiddish newspaper Di varhayt (Warheit) in New York, in 1917. The translations are accompanied by an essay that recounts Borokhov's history, scholarship, and keen interst in Jewish libraries.
Ensuring Production Continuity in an Era of Electronic Component Shortages
Authors: Pawłowicz Grzegorz
Published: January 2023

The article presents a description of the case of ensuring the continuity of production of a ticket validator device in the presence of supply shortages in the market for electronic components. The criteria for decision-making and their impact on the design of the ticket validator are considered. Solutions are proposed that can reduce the risk of production stoppage by using replacements for missing components, taking into account the minimization of the cost of such changes.
Design and Implementation of an Unmanned Underwater Vehicle with Hybrid Drive – REBA
Authors: Łarzewski Bartosz , Hałas Jakub , Powarzyński Daniel , Lewandowski Jarosław , Piskur Paweł
Published: January 2023

The article presents the design and implementation of an unmanned underwater vehicle with hybrid propulsion system. The vehicle can be controlled remotely as well as it has the ability to reach the indicated area in order to carry out reconnaissance and attack by detonating the carried load or self-destructing. The article presents both the hardware and software layers as well as the results of preliminary tests.
Model of Washing Device Using Textronic RFID Transponders
Authors: Hubacz Marcin , Pawłowicz Bartosz , Salach Mateusz , Trybus Bartosz , Kołcz Sebastian
Published: January 2023

Textronic RFID transponders extend the possibilities of home appliance design. New application can be found in the laundry technology, where by means of RFID transponders sewn into the garment it is possible to encode information and use it later to select the best washing program for a given type of fabric or to keep statistics of material usage. As part of this work, a demonstration model of a washing device using RFIDtex transponders (identifiers) was designed and built. A control system was prepared for the constructed model of a washing machine equipped with a RWD (Read-Write Device) device, supporting decision-making about the selection of a given function on the basis of data provided by RFIDtex identifiers integrated with the clothing. The effectiveness of the device was also checked using prepared samples.
Diagnosis of Communication Between the Elements of a Distributed Control System
Authors: Bednarek Marcin
Published: January 2023

The article describes selected fragments of the process diagnosing communication between a process and operator station, and between process stations of a distributed mini system based on an AC800F modular industrial controller. Conducted experiments provided information on the transmission method and location of process variable values in transferred messages. The information can be used to make a decision regarding additional transfer protections or communicating system stations with expanding user resources.
The use of a Fiber Optic Differential Interferometer in Measurements of Electric Current
Authors: Ginter Mariusz
Published: January 2023

The article presents an electric current sensor built of a fiber-optic differential interferometer using the Faraday effect in a single-mode fiber. It was applied to measure current waveforms with large amplitudes and mains frequency. The optical sensor does not introduce additional resistance and inductance into the measured circuit, which is a desirable phenomenon in this type of measurements. The magnetosensitive element is an optical fiber coil made of a quartz single-mode telecommunications fiber. The optical fiber, in which the core is twisted around its axis, is characterized by a small influence of disturbing quantities, i.e., mechanical vibrations and pressure changes, on the working of the differential interferometer by inducing linear birefringence in the glass fiber. The methods of elimination of the quantities influencing the operation of the optical fiber current sensor were proposed by reducing the linear birefringence induced in the optical fiber from these quantities. The dependence of the normalized light intensity was plotted. The results of experimental research on a design solution of a differential interferometer based on the Faraday effect, operating at a wavelength of 1550 nm, are presented. The sensor was used for measurements of sinusoidal current with a frequency of 50 Hz and amplitudes ranging 100–1500 A. The uncertainty of measurement of the electric current amplitude was determined in the range of the measured values, which was estimated at no more than 1.5 %.
Modernizing Royals and Capitalists of Kumase
Authors: Bob-Milliar George M. , Nyaaba Ali Yakubu
Published: January 2023

British imperialism bequeathed sports to former colonies. In the immediate postwar period, colonial bureaucrats intensified the modernization agenda in many of their colonial territories. The institution of horse racing was associated with the upper echelons of society in many colonies. In colonial Asante, the royals and capitalists of Kumase established the Ashanti Turf Club as the first public limited liability company in the history of horse racing in Ghana. Horse racing in Kumase started with the active encouragement and patronage of the king of Asante (Asantehene). The Kumase royals and capitalists embraced the middle-class culture and bought shares in the Turf Club. The practice of betting linked the working-class to racing. Horse racing played a significant social role in Asante society by keeping residents entertained at the weekends. This article examines the Ashanti Turf Club Limited within the context of the modernization of postwar Asante. It shows how the history of horse racing in Kumase provides a lens to understand how Africans embraced middle-class culture and colonial modernity.
Prenomes e sobrenomes no Brasil
Authors: Seide Marcia Sipavicius
Published: January 2023

Este artigo apresenta uma revisão sistemática de literatura que visa revelar a constituição dos nomes de pessoa oficiais primários na língua portuguesa no Brasil e identificar as características epistemológicas das pesquisas desenvolvidas. Para tanto, foi feita uma seleção de 15 artigos extraídos de uma lista bibliográfica contendo 44 artigos sobre Onomástica publicados de 2011 a 2021. Os resultados mostram que há grande diversidade etimológica tanto nos sobrenomes quanto nos prenomes. Com exceção dos povos nativos e dos descendentes de escravos, há correlação entre a etnia dos antepassados e a etimologia dos sobrenomes em uso no Brasil. Foram evidenciados dois tipos de nomes: convencionais, que estão integrados no repertório onomástico do Brasil em determinado período, são escolhidos em harmonia com costumes locais e estão conectados a tradições religiosas ou nacionais; e não convencionais, que destoam da categoria anterior e são avaliados como nomes diferentes e singulares. Mais de 25% das pesquisas abrangem mais de um nível linguístico de análise, uma vez que abordam os níveis etimológico, ortográfico e/ou morfológico. Constatou-se também que predominam as pesquisas de abrangência local e que, em todos os estudos, os dados foram analisados levando-se em consideração, para além do aspecto linguístico, o contexto histórico e social da fonte dos dados analisados.
Ensino de alemão com foco decolonial
Authors: Aquino Marceli , Ferreira Mergenfel Vaz
Published: January 2023

Com base nos pressupostos da linguística aplicada indisciplinar e, a partir de uma perspectiva decolonial, o presente trabalho tem como objetivo principal apresentar e discutir propostas de atividades elaboradas para um material didático de ensino de alemão como língua adicional. Esse material vem sendo desenvolvido no âmbito de um projeto interinstitucional, o projeto Zeitgeist, que visa discutir e propor um livro didático de alemão específico para o contexto acadêmico. Nesse sentido, para além da descrição das atividades em si, também serão apresentados o contexto de produção do livro e seus princípios orientadores. A proposta deste trabalho, assim como do projeto Zeitgeist, é o de refletir e atuar de maneira prática sobre o ensino e aprendizagem e a pesquisa do alemão como língua adicional em uma perspectiva pluricêntrica, focando especialmente no contexto acadêmico de formação autodirigida de professoras e pesquisadoras de alemão no Brasil. A análise realizada aponta que as atividades enfatizam questões relevantes dentro de práticas sociais contextualizadas permitindo, portanto, que professoras e estudantes se reconheçam no material e possam desenvolver um aprendizado crítico em língua alemã.
PENERAPAN MODEL GENERALIZED SPACE TIME AUTOREGRESSIVE (GSTAR) UNTUK MERAMALKAN PENERBANGAN DOMESTIK PADA TIGA BANDAR UDARA DI PULAU JAWA
Authors: Muzdhalifah Adinda Putri , Tarno Tarno , Kartikasari Puspita
Published: January 2023

The number of flights is a thing to measure the marketing performance of aviation services. Forecasting the number of flights is done so that airlines can make decisions in increasing the number of passengers and revenue. Forecasting the number of flights at various airports has relationship between time and location. The suitable method for forecasting the number of flights is Generalized Space Time Autoregressive (GSTAR) method. GSTAR is a method that used for forecasting time series data that has a relationship between time and location and has heterogeneous characteristics. This study applied the GSTAR method to model and forecast the number of domestic flights at three airports in Java, namely Husein Sastranegara Airport Bandung, Ahmad Yani Semarang, and Juanda Surabaya. The research chose those three airports because the impact of Covid-19 is very severe in that area. The weight used in this study is the distance inverse weight. The resulting model is a model with differencing 1, autoregressive order 1, and spatial order limited to 1 so that the model formed is the GSTAR model (11)-I(1). The GSTAR (11)-I(1) meets the assumptions of residual white noise and normal multivariate. The model also has sMAPE values for each airport: 2.60%, 4.18%, and 9.89%. Therefore, it can be concluded that the forecasting results of Husein Sastranegara Airport Bandung, Ahmad Yani Airport Semarang, and Surabaya Juanda Airport are very accurate.