bluuebunny/crossref_metadata_2025 huggingface dataset:
Cuidado transicional como uma aposta para a Educação permanente em saúde: Uma revisão integrativa de literatura
Authors: Macedo Gisele Vasques , Silva Ana Lúcia Abrahão da
Published: November 2024

A articulação das ações de saúde entre a Atenção Primária, Unidades de Pronto Atendimento (UPA) e Hospitais, tem se apresentado como um desafio constante para gestores, profissionais de saúde e usuários, tanto na definição de fluxos como na organização de processos de trabalho, exigindo entendimento e consenso por parte dos diferentes atores. Nesta direção, a Política Nacional de Educação Permanente em Saúde, orientada a operar no cotidiano dos serviços reformulando práticas e adotando princípios educacionais como parte integrante do processo contínuo de transformação do Sistema Único de Saúde (SUS), pode configurar como um dispositivo de integração e organização do trabalho em saúde durante o cuidado transicional entre os níveis de atenção. O objetivo principal deste artigo foi investigar, na literatura nacional e internacional, evidências científicas sobre a Educação Permanente como ferramenta de gestão e de cuidado na transferência entre os níveis de atenção à saúde, com ênfase em uma abordagem centrada no usuário. Para a revisão integrativa de literatura, foram criados quadros demonstrativos para facilitar o processo de seleção. Foram identificados 16 artigos científicos obtidos nas bases de dados LILACS, MEDLINE e BDENF no período de 2018 a 2023, em inglês e português. Os resultados indicaram uma correlação entre Educação Permanente, cuidado centrado no paciente e cuidados de transição, ressaltando a importância da comunicação efetiva e da assistência humanizada. Conclui-se que é necessário explorar mais estudos nessas áreas durante os processos de trabalho na atenção secundária para efetivar um cuidado centrado no paciente.
Palavras-Chave: Educação Permanente; Acolhimento; Cuidado transicional; Atenção Secundária à saúde; Cuidado Centrado no Paciente.
Reflexões bioéticas sobre os princípios da solidariedade, cooperação e compartilhamento de benefícios em um contexto internacional – o continente africano com destaque em Moçambique
Authors: Cademo Pessi Lourenço , Cruz Eliane Aparecida da , Façanha Telma Rejane dos Santos
Published: November 2024

O Artigo 13 - Solidariedade e cooperação - e o Artigo 15 - Compartilhamento de benefícios da Declaração Universal sobre Bioética e Direitos Humanos da Unesco buscam enriquecer a compreensão sobre esses princípios éticos, tendo como base a necessidade de dialogar sobre sua aplicabilidade diante das diversidades política, social, econômica e cultural do planeta. Neste artigo, são apresentados dados da realidade dos serviços de saúde e educação na África, especialmente em Moçambique, onde a injustiça no acesso a serviços de saúde e educação exige contraposição em favor da promoção e proteção dos direitos humanos. Tais serviços podem ser incentivados pela solidariedade e cooperação internacional, por meio do compartilhamento de benefícios científicos e tecnológicos entre países desenvolvidos e países periféricos. Isso pode gerar mudanças de paradigmas, em que a solidariedade vertical e hegemônica da cooperação Norte-Sul seja pautada por um olhar bioético bilateral e horizontal, sem discriminação e em direção à promoção da igualdade, justiça social e respeito à dignidade humana e ao pluralismo moral. Pretende-se também fazer uma reflexão sobre a forma de gestão de bens solidários por parte dos gestores dos países beneficiários, em particular Moçambique.
Palavras-chave: Bioética; Solidariedade e Cooperação; Compartilhamento de Benefícios; Justiça Social.
Metilfenidato para tratamento de Crianças e Adolescentes com TDAH
Authors: Silveira Lucas Zappa Monte Lima , Rocha Mirelli Katzuk de Carvalho , Souza Anna Clara Martinelli de , Cunha Gabriela de Oliveira , Grunewald Tatiana Mara dos Santos Azevedo , Telles Barbara da Silva Soares
Published: November 2024

O transtorno do déficit de atenção e hiperatividade (TDAH) é uma condição neuropsiquiátrica mais comumente diagnosticada em crianças e adolescentes, normalmente caracterizada por desafios de aprendizagem e concentração em idade escolar, e que, uma vez sem tratamento, pode perdurar até a vida adulta. O Metilfenidato (MPH), é um fármaco psicoestimulante, considerado a opção terapêutica de primeira linha para pacientes a partir de 6 anos de idade, responsável por atuar diretamente na melhora dos sintomas de hiperatividade, desatenção e impulsividade. Através das análises de estudos obtidos a partir da busca por trabalhos prévios nas bases de dados PubMed e Portal Regional da BVS, e a seleção de 25 artigos científicos que se adequaram aos parâmetros do estudo, foi demonstrado que o MPH confere eficácia, segurança e tolerância para essa faixa etária. Em complemento, o estudo aborda também a terapia comportamental como padrão para crianças menores de 6 anos, posto que este grupo não se adequa à eficácia prevista pelo MPH. Contudo conclui-se que o MPH possuie criterios suficientes para se enquadrar como tratamento de escolha do TDAH em crianças e adolescentes.
Palavras-Chave: Metilfenidato; TDAH; Crianças.
TLR2 Activation as a Marker of Severe COVID-19 and a Potential Therapeutic Target
Authors: Mao Xianxian , Wu Yijia , Zhang Xinyi , Zhou Tian , Huang Houda , Fu Mingui , Qian Yisong
Published: November 2024

SARS-CoV-2-induced COVID-19 has been a serious public health problem,
resulting in millions of lives lost over the previous three years. Although the direct infection
caused by virus invasion is important for the pathobiology of COVID-19, the hyperinflammatory
response and tissue injury are major contributors in critically ill patients.
As a host sensor, toll-like receptor 2 (TLR2) recognizes multiple pathogen-associated
molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs), producing
various inflammatory cytokines and inflammatory cell death signals, which are central
to the inflammatory pathology observed in COVID-19. The objectives of this narrative
review are to summarize the role of TLR2 activation during SARS-CoV-2 infection
and emphasize the importance of SARS-CoV-2 viral proteins in TLR2 activation. Additionally,
we presented some compounds related to TLR2 regulation clinically or experimentally,
which may provide new insights into targets for pharmaceutical discovery and
development.
Exosomal Delivery of miR-155 Inhibitor can Suppress Migration, Invasion, and Angiogenesis Via PTEN and DUSP14 in Triple-negative Breast Cancer
Authors: Razaviyan Javad , Sirati-Sabet Majid , Hadavi Razie , Karima Saeed , Rajabi Bazl Masoumeh , Mohammadi-Yeganeh Samira
Published: November 2024

Introduction:

Triple-Negative Breast Cancer (TNBC) is the most common
type of breast cancer (BC). In order to develop effective treatments for TNBC, it is vital
to identify potential therapeutic targets. Angiogenesis stimulates tumor growth and metastasis
in TNBC, and miR-155 plays a crucial role in this process. The exosome is a
nano-sized vesicle that carries many cargoes, including miRNAs. The present study investigated
the effect of exosomal delivery of miR-155 antagomir on tumor migration, invasion,
and angiogenesis in TNBC.

Materials and methods:

From MDA-MB-231 cells, exosomes were extracted, characterized,
and loaded with miR-155 antagomir using electroporation. The expression of
miR-155 and its target genes, including PTEN and DUSP14, was analyzed using RTqPCR.
The wound-healing and transwell assays were used to measure cell migration and
invasion. Furthermore, angiogenesis was evaluated by tube formation and chorioallantoic
membrane (CAM) assays.

Results:

The results indicated that exosomal delivery of miR-155 antagomir to HUVEC
cells significantly suppressed miR-155 expression while upregulating PTEN and DUSP14.
The tube formation properties of HUVEC cells were also significantly reduced following
treatment with exosomes containing miR-155 antagomirs, and these results were
confirmed using CAM assay. The migration and invasion of MDA-MB-231 cells were
significantly reduced after treatment with miR-155 antagomir-loaded exosomes.

Conclusion:

It was found that miR-155 antagomir delivery using exosomes can inhibit
migration, invasion, and angiogenesis viaPTEN and DUSP14 in TNBC.
Galangin Regulates Astrocyte Phenotypes to Ameliorate Cerebral
Ischemia-reperfusion Injury by Inhibiting the RhoA/ROCK/LIMK Pathway
Authors: Liu Nannuan , Xu Yue , Liu Yao , Chen Tao , Hu Wenli
Published: November 2024

Purpose:

This study aimed to explore whether Galangin (Gal) could improve cerebral Ischemia-
reperfusion (I/R) injury by regulating astrocytes, and clarify its potential molecular mechanism.

Methods:

An I/R injury model of rats was established using the Middle Cerebral Artery Occlusion/Reperfusion
(MCAO/R) method, followed by the administration of Gal (25, 50, 100 mg/kg) via gavage for 14 consecutive
days. Besides, astrocytes were isolated from the rats to construct an Oxygen-Glucose Deprivation/Re-oxygenation
(OGD/R) cell model, with treatments of Gal or the Ras homolog gene family member A
(RhoA)/Rho-associated Coiled-coil containing protein Kinase (ROCK) inhibitor Y-27632. Subsequently, the
severity of nerve injury was assessed using the modified Neurological Severity Score (mNSS) test; behavioral
disorders in I/R rats were observed through the open field and ladder-climbing tests. Pathological damages and
neuron survival in the peri-infarct zone were examined by hematoxylin and eosin staining and NeuN staining,
respectively. Additionally, immunofluorescence staining was employed to determine astrocyte polarization
and TUNEL staining was carried out to measure the level of cell apoptosis; also, western blot was performed
to detect the expression of proteins related to the RhoA/ROCK/LIM domain Kinase (LIMK) pathway.

Results:

Gal significantly ameliorated the neurological and motor dysfunctions caused by I/R in rats, reduced
pathological damage in the peri-infarct zone, and promoted neuronal survival. Additionally, Gal increased the
number of A2 astrocytes, while it decreased the number of A1 astrocytes. In vitro experiments revealed that
the effect of Gal was consistent with that of Y-27632. Additionally, Gal significantly enhanced the survival of
OGD/R cells, increased the number of A2 astrocytes, and inhibited the expression of proteins associated with
the RhoA/ROCK pathway.

Conclusion:

Gal could reduce the level of apoptosis, promote the polarization of A2 astrocytes, and improve
cerebral I/R injury, and its mechanism may be related to the inhibition of the RhoA/ROCK pathway.
Influence of Nanomedicine as a Smart Weapon on Multidrug Resistance in Cancer Therapy
Authors: Paikray Safal Kumar , Sahoo Liza , Tripathy Nigam Sekhar , Dilnawaz Fahima
Published: November 2024

Cancer is the leading cause of death worldwide. The effectiveness of chemotherapy in
cancer patients is still significantly hampered by Multidrug Resistance (MDR). Tumors exploit
the MDR pathways to invade the host and limit the efficacy of chemotherapeutic drugs that are
delivered as single drugs or combinations. Further, overexpression of ATP-binding Cassette
transporter (ABC transporter) proteins augments the efflux of chemotherapeutic drugs and lowers
their intracellular accumulation. Recent progress in the development of nanotechnology and
nanocarrier-based drug delivery systems has shown a better perspective with respect to the improvement
of cancer chemotherapy. Nanoparticles/nanomaterials are designed to target the immune
system and tumor microenvironment of cancer cells for a variety of cancer treatments in
order to improve bioavailability and reduce toxicity. This review elucidates the successful use of
nanomaterials for cancer therapy and addressing the MDR and throws some light on the present
obstacles impeding their translation to clinical use.
Cetuximab scFv-Modified 5-FU Loaded Chitosan Nanoparticles: "A Novel Therapeutic Platform."
Authors: Jalalvand Masumeh , Esmaeili Fariba , Falahzadeh Khadijeh , Mazloumi Mohammadali , Shahsavari Gholamreza , Bayat Elham , Zandsalimi Farshid , Talebkhan Yeganeh , Nematollahi Leila , Negahdari Babak
Published: November 2024

Background:

Colorectal cancer [CRC] is among the most fatal types of cancer. An
active targeting delivery system that specifically interacts with CRC cells could improve the
therapy's outcomes. Herein, Cetuximab single-chain fragment variable antibody [scFv] fragments
were conjugated to the surface of 5-FU encapsulated chitosan nanoparticles [CS NPs] to
develop an effective therapeutic platform [scFv-CS/5-FU NPs].

Method:

CS/5-FU NPs were synthesized using a special fluidic system. Encapsulation efficiency
[EE], loading capacity [LC], and the drug release profile of the particles were determined. scFv
fragments were produced recombinantly and tailored on the surface of CS/5-FU NPs. The physicochemical
features of scFv-CS/5-FU NPs were also characterized. MTT and flow cytometry
assay investigated the toxicity effect of scFv-CS/5-FU NPs on the HCT116 cell line.

Results:

CS/5-FU NPs had a homogenous spherical shape. They possessed sustainable drugrelease
behavior. The produced scFv-CS/5-FU NPs were also spherical. scFv-CS/5-FU NPs significantly
decreased the viability of cancerous cells in a dose-dependent manner and induced
apoptosis in 97.97% of targeted cells.

Conclusion:

scFv-CS/5-FU NPs showed remarkable anti-CRC activity. This novel targeting
delivery system reduced the effective dose of 5-FU which is of vital importance to decrease the
devastating side effects of chemotherapy.
LncRNA HAGLROS: A Vital Oncogenic Propellant in Various Human Cancers
Authors: Yang Jingjie , He Haodong , Chen Lihan , Wei Yuzhang , Liu Yulong , Li Xiaolan , Yuan Chengfu
Published: November 2024

HAGLR Opposite Strand lncRNA (HAGLROS) is a long non-coding RNA (lncRNA)
located on the long arm of human chromosome 2 at locus 2q31.1. Emerging evidence highlights
HAGLROS as a pivotal player in human cancers, characterized by its significant upregulation
across multiple malignancies where it functions as an oncogenic driver. Its aberrant expression is
closely linked to the initiation and progression of 13 distinct cancer types, notably correlating with
adverse clinical outcomes and reduced overall survival rates in 9 of these cancer types. Mechanistically,
HAGLROS is under the regulatory influence of the transcription factor STAT3, exerts competitive
binding to 9 miRNAs, activates 5 signaling pathways pivotal for cancer cell proliferation
and metastasis, as well as intricately modulates gene expression profiles. Given its multifaceted
roles, HAGLROS emerges as a promising candidate for cancer diagnostics and prognostics. Moreover,
its potential as a therapeutic target holds considerable promise for novel treatment strategies
in oncology. This review synthesizes current research on HAGLROS, covering its expression patterns,
biological roles, and clinical significance in cancer. By shedding light on these aspects, this
review aims to contribute new perspectives that advance our understanding of cancer biology, enhance
diagnostic accuracy, refine prognostic assessments, and pave the way for targeted therapeutic
interventions.
The Ability of Indigenous Plants in Alleviating Rheumatoid Arthritis: A Comprehensive Review
Authors: Khan Aslam , Mazumder Avijit , Pentela Bhavani , Mishra Rashmi , Singh Sachin Kumar
Published: November 2024

Rheumatoid Arthritis is a long-lasted, inflammatory, systemic autoimmune disease that
predominantly manifests in people between the ages of 30 and 50 Rheumatoid arthritis is characterized
by more than a half-hour of morning stiffness in the affected joints, fever, soreness,
swelling, weight loss, tiredness, warm joints, and subcutaneous rheumatoid nodules. Hormonal, genetic,
epigenetic, reproductive, and neuroendocrine risk factors, as well as comorbid host variables,
are the categories of host-related risk factors associated with the evolution of RA. Additional
risk variables that have been linked to RA include food, environmental variables, socioeconomic
status, smoking, microbiome, infection agents, and other airborne exposures. The objective of
RA therapies is to minimise joint deformity and destruction, minimise discomfort and inflammation
in the joints, and maximise joint function.Growing data suggests that the course of Rheumatoid
Arthritis is affected by the minimisation of disease activity caused by disease-modifying medications,
and that patients may benefit from early antirheumatic medication delivery that modifies
illness. While numerous herbs have been explored for their anti-inflammatory properties, it is important
to note that not all herbs have been thoroughly researched. This review focuses on seventeen
native plant species that have shown either promising or established anti-arthritic effects
based on preclinical and clinical studies where available. The review highlights the biochemical
and immunological attributes of these herbs, summarizing their therapeutic potential for RA management
while also acknowledging the limitations and gaps in current research. This examination
provides insights into the potential of these herbal treatments for RA and calls for further research
to explore their efficacy and safety in greater depth.
Facial Hyperpigmentation Following Adalimumab
Authors: Yasmine Salem Mahjoubi , Imen Aouinti , Israa Dahmani , Fatma Zgolli , Ons Charfi , Sihem El Aidli
Published: November 2024

Background:

Tumor necrosis factor alpha (TNF-α) inhibitors, such as adalimumab,
have significantly advanced the treatment of inflammatory diseases. However, these therapies are
associated with various cutaneous adverse reactions.

Case Presentation:

We describe two rare instances of isolated facial hyperpigmentation induced
by adalimumab. Both patients presented with asymptomatic, isolated brown macules on the
cheeks following adalimumab treatment for ankylosing spondylitis. The hyperpigmentation appeared
shortly after starting the medication in both cases. In one case, the hyperpigmentation persisted
despite stopping the medication, while in the second case, it completely resolved within one
month after discontinuation. However, in the second patient, the hyperpigmentation recurred after
switching to certolizumab, another TNF-α inhibitor. No skin biopsies were performed, and both
patients were otherwise healthy, with normal laboratory evaluations.

Conclusion:

Hyperpigmentation is an uncommon adverse reaction of this class of drugs, with only
a few reported cases in the literature. The recurrence of hyperpigmentation after switching to
another TNF-α agent, certolizumab, further suggests that this reaction may be a class effect, adding
new insights into the spectrum of cutaneous side effects associated with TNF-α inhibitors.
Clinicians should consider this potential side effect in patients presenting with hyperpigmentation,
and sun protection should be recommended as a preventive measure.
Acute Myeloid Leukemia Presenting as Extensive Arterial and Venous Thrombosis: A Case Report
Authors: Kachhwaha Arjun , Shah Bibhant , Ronanki Kavya , Dalton Prisla Maria , Nath Uttam Kumar
Published: November 2024

Background:

Thromboembolism with solid malignancies is a commonly associated feature,
which is less common in hematological malignancies. Disseminated intravascular coagulation
(DIC) causing thrombotic events is characteristically associated with certain hematological
malignancies (e.g., acute promyelocytic leukemia (APL). Acute myeloid leukemia (AML) presenting
as extensive thromboembolism is not a common clinical presentation. Anticoagulation in these
subsets of patients remains a major challenge since patients often have thrombocytopenia and
bleeding manifestations, requiring close monitoring.

Case Presentation:

A 54-year-old male with a known case of ischemic heart disease on regular anti-
platelet therapy presented with acute onset progressive shortness of breath with mild anemia.
On further evaluation, the patient was diagnosed with bilateral pulmonary artery and venous
thrombosis along with left complete renal and partial inferior vena cava (IVC) thrombosis. The patient
was started safely on anticoagulant therapy with normal platelet counts. Later, peripheral
smear and immunophenotyping by flow cytometry revealed the diagnosis of acute myeloid
leukemia, and the patient started its treatment.

Conclusion:

Extensive arterial and venous thrombosis at presentation of acute myeloid leukemia
is an uncommon finding and needs anticoagulation therapy along with the treatment of the underlying
disease. Close monitoring of bleeding and maintaining an adequate platelet count is required,
especially in hematological malignancies.
Enhancing Therapeutic Impact of Curcumins, through Development of Monocarbonyl Analogues of Curcumin for Improved Bioavailability and Activity in Healthcare
Authors: Teli Shriya K. , Suvarna Vasanti M. , Abhyankar Arundhati N.
Published: November 2024

Turmeric (Curcuma longa L.) is renowned for its therapeutic properties, such as antitumor,
antioxidant, anticancer, and antiinflammatory effects. Despite its safety, the usefulness of
curcumin, a prominent polyphenolic compound derived from the rhizome of Curcuma longa L., is
limited by factors such as low bioavailability, poor absorption, rapid metabolism, and quick systemic
elimination. Despite these challenges, researchers continually explore therapeutic potential of curcumin’s
through the development of novel delivery systems and chemical modifications such as
monocarbonyl analogues of curcumin (MACs) which lack one carbonyl group present in the native
structure. Recent studies on MACs have shown promising antiinflammatory, anticancer, and antidiabetic
properties. In summary, the development of MACs and other chemical modifications of curcumin
presents a promising avenue to improve the bioavailability and pharmacological activities of this
natural compound. The objective of this review is to understand structure-activity relationships that
will guide further investigations and applications of MACs in therapeutics and help in enhancing
curcumin’s bioavailability and pharmacological activities.
Impact of Anaemia on Cognitive Impairment and Depression Levels Among Young Adults: A Cross-sectional Study Highlighting Gender Disparities
Authors: Chandrasekaran Vinitha , Varghese Neena Elsa , K Krishnaveni , R Kameswaran
Published: November 2024

Background:

Anaemia is a significant health epidemic affecting all
age groups, especially adults. This study aimed to identify the impact of cognitive
impairment and depression levels according to potential risk factors among young
anaemic adults.

Materials and Methods:

A cross-sectional study was conducted among 546
adults aged 17-25 years. Haemoglobin levels were measured using Sahli's
method. Socio-demographic and risk factor data were collected via a
questionnaire. Depression and cognitive impairment levels were assessed using
the Patient Depression Questionnaire-9 (PDQ-9) and the Cognitive Assessment
Questionnaire (CAQ), respectively. ANOVA and Spearman's correlation were
used to explore the relationship between anaemia, cognitive impairment, and
depression levels. The mean age of participants was 19.41 years (SD = 1.47).
Gender distribution included 204 males (mean age = 19.2 years, SD = 1.4) and
342 females (mean age = 19.5 years, SD = 1.5).

Results:

The overall prevalence of anaemia was 73.2%, with 29.4% males and
43.7% females. Most anaemic patients (52.3%) had a mild degree of anaemia.
Among anaemic patients, 48.25% experienced forgetfulness, 44.25% had
distractibility, 25.7% had false triggering, and 16.2% reported no cognitive
issues. About 37.2% of anaemic patients fell under minimal depression.

Conclusion:

The study concludes that there is a significant impact of anaemia on
cognitive impairment and depression levels among young adults. Therefore,
raising awareness about anaemia in young adults is crucial to prevent
complications later in adulthood and during pregnancy.
Prooxidant Activity of Gallic Acid by Promote Reactive Oxygen Species, Apoptosis and Autophagy in HepG2 Cells In Vitro
Authors: Sabahi Zahra , Aghashiri Zahra , Emami Mahsa Zare , Shafaghat Marzieh , Iranpak Forough , Arabsolghar Rita , Alimohammadi Mahshid , Rashedinia Marzieh
Published: November 2024

Introduction:

Gallic acid (GA), a natural phenolic acid, has been reported as an antitumor
agent in various cancer cells. Although some mechanisms, such as apoptosis, are well
known, the details of other mechanisms, such as their pro-oxidant and autophagy activity, are still
considerable.

Methods:

The pro-oxidative activity and anti-proliferative activity of GA on HEK 293 and HepG2
cells were measured in the absence and presence of exogenous Cu (II) and Fe (II). Furthermore,
colony forming, ROS generation, apoptosis induction, autophagy and mitochondrial membrane potential
(MMP) were examined.

Results:

HepG2 cells treated with GA + Cu (II) significantly reduced cell viability (p <0.001). GA
+Cu (II) induced morphological changes in HepG2 cells and stimulated apoptotic cell death. Moreover,
GA +Cu (II) triggered the mitochondrial-dependent apoptotic pathway by increasing intracellular
ROS levels and disrupting MMP. Furthermore, GA+ Cu (II) significantly reduced the Plating Efficiency
and Surviving Fraction while increasing autophagic vacuoles in the HepG2 cells.

Conclusion:

According to our results, GA played a pro-oxidant role in the presence of Cu (II), triggered
apoptosis by increased ROS and disruption of MMP. This combination also induced autophagy
in HepG2. These effects hold promise for future anticancer research.
Current Applications of Organocatalysis in Total Synthesis of Natural Products at Room Temperature
Authors: Lohar Sisir , Mitra Piyali , Majhi Sasadhar
Published: November 2024

Molecules of natural origin play a profound role in drug discovery and development since
natural products derived from Mother Nature, particularly from plants are employed as satisfactory
precursors for important medicines. The total synthesis of complex natural products endures as a
dynamic field of chemical research as the demand for bioactive natural products and secondary metabolites
is gradually enhancing owing to their great application in the area of synthetic organic
chemistry and the biological community. It is very useful in ascertaining the hypothetical complex
structure of such molecules in the laboratory since different biologically potent secondary metabolites
are derived in small quantities frequently. The total synthesis of natural products using organocatalysis
as the key step(s) has earned momentum recently because of high chemical efficiency, low
toxicity, simple accessibility, low cost, and eco-friendly of organocatalysts due to the absence of a
metal atom as well as the popularity of asymmetric catalysis research. This greener strategy is capable
enough to execute the transformations at ambient temperature as per the sixth principle of green
chemistry which is dedicated to the “Design for Energy Efficiency”. Cinchona alkaloids, chiral secondary
and primary amines, guanidine and guanidiniums, N-heterocyclic carbenes, etc. are important
organocatalysts in the field of the total synthesis of natural products and related compounds. Thus,
the present review aims to deal with the total synthesis of natural products at room temperature as
crucial intermediate(s) and it also offers an overview of natural sources, structures, and biological
activities of natural products for the first time modishly.
Fortifying SNEDDS with Hybrid Technologies: Present and Future Prospects
Authors: Shanthi Nithya , Arora Khushbu , Pant Himani , Soni Komal , Gupta Geetika , Chandra Gaurav , Mahato Arun Kumar
Published: November 2024

Self-nano-emulsifying drug delivery systems (SNEDDS) have gained attention in recent
years as an effective approach for improving the solubility and oral bioavailability of poorly
water-soluble drugs. However, there have been reports of drawbacks such as low drug loading,
limited stability and variability in absorption. Various technologies have been investigated in conjunction
with SNEDDS to alleviate such issues such as polymers being used to improve stability
and drug loading; phospholipid complexes used to improve absorption and reduce inter and intrasubject
variability; SNEDDS for drug targeting improves the targeting of drugs to specific site reducing
the dosage required for action. 3D printing is used to create personalized and precise
dosages; supersaturated SNEDDS is used to increase drug concentration; and solid SNEDDS are
used to improve storage stability and patient compliance. The amalgamation of SNEDDS with these
technologies has demonstrated promising results with regard to the improvement of medication
delivery and has control over SNEDDS limitations. The present review elucidates the application
of blended technologies with SNEDDS and the future potential for such drug delivery.
Deciphering Plasmodium Condensin Core Subunits of Structural Maintenance of Chromosomes 2 (SMC2) as a Putative Drug Target for Antimalarial Drug
Authors: Chauhan Uma , Datta Manali , Kaushik Sanket , Sharma Vinay , Piplani Sakshi , Niraj Ravi Ranjan Kumar
Published: November 2024

Background:

The structural maintenance of chromosomes (SMC) proteins
plays a noteworthy role in chromosome dynamics. Several recent studies reported that the
condensin core subunits of structural maintenance of chromosomes 2 (SMC2) play important
roles in the atypical mitosis of the Plasmodium life cycle and may perform different
functions during different proliferative stages. For eukaryotes, the structural maintenance
of chromosomes (SMC) proteins are divided into six subunits and form three heterodimers
of structural maintenance of chromosomes (SMC1/3) cohesion complex, structural
maintenance of chromosomes (SMC2/4) condensin complex, and structural maintenance of
chromosomes (SMC5/6) complex for chromosome cohesion, condensation, and DNA
damage repair, respectively.

Objective:

The objective of this study was to investigate the structural maintenance of
chromosomes 2 (SMC2) protein of P. falciparum as a putative drug target of malariacausing
Plasmodium falciparum.

Methods:

In this study, we investigated the structural maintenance of chromosomes 2
(SMC2) protein of P. falciparum as a putative drug target of malaria-causing P. falciparum
by using in-silico approaches like Homology modeling, in-silico evaluation of the modeled
structure, molecular docking study to investigate the interaction of receptor-ligand, and
molecular dynamic simulation study with MM calculation.

Results:

We reported the structural maintenance of chromosomes 2 (SMC2) protein of P.
falciparum as a potent drug target that can pave the way for novel drug discovery to mitigate
malaria.

Conclusion:

In-silico-based studies play a significant role in understanding any protein for
potential drug development.
Advisory content in politics: the form of mitigation of the negative impact of identity politics on Instagram account @lensamu and @nuonline_id
Authors: Istiati Fuandani , ‘Aziizah ‘Aabidah Ummu
Published: November 2024

This article aims to analyze efforts to mitigate the negative impacts of identity politics by two large mass organizations in Indonesia, Muhammadiyah and Nahdhatul Ulama (NU), through their Instagram accounts. Mitigation in this context refers to steps to recognize and increase awareness of identity politics risks often occurring in campaigns, especially before the 2024 election. This research is motivated by the political situation leading up to the 2024 election and vulnerability to identity politics, which perpetrators often use as a tool. The method used in this research is quantitative content analysis with content research objects discussing political themes and the 2024 election. Data was collected through virtual observation, literature research, and online documentation via the Instagram accounts @lensamu and @nuonline_id from September 2023 to February 2024. Based on the research results, it can be concluded that the percentage of forms of mitigating the negative impact of identity politics carried out by the @lensamu account is 0.91 or 91% and by @nu_online it is 0.86 or 86%. With these test results, it can be said that the form of mitigation of the negative impact of identity politics carried out by these two accounts is high in facing the 2024 election.
The Communication Style of Habib Jafar's Da'wah on TikTok Social Media
Authors: Naqisa Zikrina Istighfara , Fadillah Dani
Published: November 2024

This research aims to explore in depth the communication style of Habib Ja'far's preaching on the social media TikTok. Husein Hadar Jafar or more commonly known as Habib Jafar, who is a young preacher, uses the TikTok platform as a means of preaching which is attractive to many young millennials and Gen Z. This researcher used a descriptive qualitative approach, with an audio-visual method of analyzing the content of R. Hosetly's TikTok account @husein jafar. Other sources were obtained using various references in the form of scientific journals, books, and media coverage. The conclusion obtained from this research is that the preaching communication style on TikTok social media uses inductive qualitative. Habib Jafar preaching through the TikTok platform invites the younger generation to re-acquaint themselves with Islam with an assertive communication style.
The impact of foreign direct investment on economic growth: Empirical evidence in G20 countries
Authors:   College of Business, Effat University, Jeddah, Saudi Arabia, Almalik Rasha , Shaheen Rozina ,   College of Business, Effat University, Jeddah, Saudi Arabia, Ahmed Manzar ,   College of Business, Effat University, Jeddah, Saudi Arabia
Published: November 2024

This study investigates how foreign direct investment (FDI) affects economic growth in G20 countries. It uses annual panel data from 19 countries for the years 2001 and 2022. In addition to FDI as the main independent variable, the study includes control variables such as exchange rates, trade balance, inflation, government effectiveness, and gross fixed capital formation. The relationship between economic growth and FDI is analyzed using Johansen's cointegration method and a vector error correction model. First, unit root tests were conducted using the Augmented Dickey-Fuller (ADF) test. Granger causality tests were also applied to identify the direction of causality between FDI and economic growth. To ensure the reliability of the results, three different panel linear regression models were used to confirm the robustness of the findings. The results from all econometric models consistently show that FDI has a positive and statistically significant effect on the economic growth of G20 countries. Additionally, gross fixed capital formation and exchange rate appreciation were found to have positive and significant effects on economic growth. On the other hand, inflation and trade openness negatively impacted economic growth. Government effectiveness was found to be insignificant, and its moderating role was not further analyzed. Based on these findings, the study recommends that governments implement policies to attract FDI, as it promotes technology transfer, increases market competition, and introduces new expertise, all of which contribute to economic growth. Additionally, governments should create a stable economic environment by implementing strict monetary policies to control inflation and support long-term economic development.
Phenotypic Characterization of Advanced Breeding Lines of Rice (Oryza sativa L.) for Drought and Low Phosphorus Stress Tolerance
Authors: Jahin Sopnil Ahmed , Das Biswajit , Abdullah Adrita , Akter Sadia , Siddique Mohammad Abu Kawsar Sarower , Hossain Mohammad Anwar
Published: November 2024

Drought and phosphorus (P) deficiency stress are two significant natural abiotic stresses restricting rice growth and yield worldwide. Developing rice varieties tolerant to drought and low P stress is crucial for sustainable agricultural production. To address these issues, two separate experiments were conducted using selected advanced rice breeding lines to study the impact of drought and low P stress on yield-attributing traits. The first experiment evaluated the drought stress tolerance of five advanced lines (Lines 14, 16, 20, and 22) under pot culture conditions by applying drought stress and not providing water throughout the reproductive stages (late booting to ripening). All genotypes under study exhibited a significant reduction in the yield of grain, ranging from 75.68% to 39.52%, as well as spikelet fertility and SPAD value when drought stress was applied; however, Line 20, BRRI dhan71, and Nerica 10 showed a less significant decrease. Conversely, days to first flowering, days to maturity, and the number of unfilled grains increased significantly in all of the genotypes studied; however, Line 20, BRRI dhan71, and Nerica10 showed a slight increase. Based on stress tolerance indices, Nerica 10, BRRI dhan71, and Line 20 are the best performers. In the second experiment, four advanced lines (Lines 3, 4, 6, and 20) were evaluated for low phosphorus (P) stress tolerance under conditions where no P fertilizer was applied. The application of low P stress significantly harmed all of the yield characteristics (excluding days to first flowering, days to maturity, and number of unfilled grains) of most of the genotypes, while Binadhan-17, Line 4, and Line 20 displayed a milder reduction, with overall grain yield reductions across genotypes ranging from 40.74% to 8.78%. Binadhan-17 and Line 20 showed higher stress tolerance indices and were classified as low P-tolerant genotypes. Considering both experimental results, the advanced breeding Line 20 was categorized as a promising advanced line. Therefore, Line 20 could be a potential donor parent for breeding drought and P deficiency-tolerant rice varieties.
Feasibility of Sexual Health and Contraceptive Web Services for Adolescents and Young Adults: Retrospective Study of a Pilot Program on Reunion Island
Authors: Reynaud Danielle , Bouscaren Nicolas , Cartron Emmanuelle , Marimoutou Catherine
Published: November 2024

Background

Sexual health indicators for adolescents and young adults (AYAs) aged between 13 and 25 years are particularly poor on Reunion Island. Access to accurate information as well as sexual health and contraceptive services are vital to maintaining sexual well-being. Teleconsultations offer a promising approach to addressing the sexual health and contraceptive needs of AYAs who are more susceptible to engaging in unprotected sexual intercourse. However, the literature on digital sexual health services for this demographic group is limited.

Objective

This study aims to describe the feasibility of a pilot sexual health and contraceptive teleconsultation web service used by AYAs on Reunion Island.

Methods

A descriptive, retrospective study was conducted at the Reunion Island University Hospital Center using a convenient sample. Eligible participants were informed about the program through various communication channels, including seminars for health care professionals, radio broadcasts, posters, flyers, press articles, videos, and social media posts. AYAs accessed a web-based platform named SEXTUOZE from December 15, 2021, to September 30, 2022, that offered sexual health information and teleconsultations. Data collected included participant and teleconsultation characteristics, patient satisfaction, and the quality of completeness of medical records.

Results

A total of 22 teleconsultations were scheduled and 7 were completed, all via synchronous video communication (duration: median 35 min). Overall, 4731 sessions were generated on the SEXTUOZE website. Reasons cited for accessing the web services were to seek sexual health advice (8/22, 36%), receive an initial birth control prescription (12/22, 55%), and inquire about condom prescriptions (2/22, 9%).

Conclusions

While teleconsultation use for sexual health was initially low, it rose toward the end of the study period. Considering all elements of the implementation theory, future research should design interventions that not only are more operative and tailored but also ensure their adoption and sustainability in various health contexts.
How Does Misperception of Others Affect One's Own Waste Sorting Behavior?—A Study from Chinese Sample
Authors: Jiang Tao
Published: November 2024

People often misestimate (overestimate or underestimate) the attitudes and behaviors of others in the group, that is, normative misperception (including behavioral misperception and attitudinal misperception) ,which can affect one's own decision-making behavior in turn. This study based on a sample of 1,460 Chinese individuals confirmed that: (1) Overestimated normative misperception positively promoted individuals' own waste sorting behavior, and underestimated normative misperception had no effect on waste sorting. (2) Overestimated behavioral misperception increased individuals' waste sorting behavior, and this effect was mediated by the “impression management motivation-personal norm” chain path. (3) Overestimated attitudinal misperception also increased individual waste sorting behavior, and this effect was mediated by the “impression management motivation-personal norms” and “consequence awareness-personal norms” chain paths.
Dynamic Performance of Concrete Considering Initial Stresses and Creep
Authors: Savin S. Yu. , Sharipov M. Z.
Published: November 2024

In accidental design situations, the loading mode of reinforced concrete structures includes two typical stages such as long-term deformation under constant or slowly varying load and dynamic impact. The purpose of the presented research was to reveal the peculiarities of stress-strain state of concrete under two-stage static-dynamic loading caused by an emergency situation. To achieve this purpose, the experimental investigations of concrete specimens in the form of prisms were carried out under different loading modes, including quasi-static and dynamic loading. The influence of the presence or absence of a long-term loading stage was also considered. It was shown that long-term loading at a stress level of 0.6 of the ultimate strength had a positive effect on the strength of concrete both in quasi-static tests and in dynamic loading. The hardening coefficient in quasi-static tests was 1.07 for the first series specimens and 1.10 for the second series specimens. The dynamic hardening was 1.20 for the first series specimens and 1.32 for the second series specimens.
The Influence of Various Factors on the Deflections and Strength of Profiled Sheeting at the Stage of Concreting a Steel-Reinforced Concrete Slab
Authors: Shaposhnikova Yu. A.
Published: November 2024

The aim of the work was to study the influence of the span, slab thickness, grade and thickness of the corrugated sheet on the deflections of the profiled sheeting at the concreting stage of the composite slab. The object of the study was orthotropic composite slabs made using on permanent formwork in the form of profiled sheeting of grades H75, H144, H153 according to GOST 24045–2016 and TRP200 according to GOST R 52246, with a thickness of 0.7–1.5 mm. A calculation and analytical method of research was used, based on regulatory documents in force in the Russian Federation. Based on the results of the study, the influence of deflections and strength of the corrugated sheeting on the applicability of various spans of corrugated sheeting in the range from 3 to 6 m at the concreting stage of the composite slab was analyzed. Recommendations are proposed to limit the use of small thicknesses of corrugated sheets of 0.7–1.0 mm for spans over 4 m for slabs less than 250 mm thick with grades of corrugated sheets H114 and H153 according to GOST 24045–2016. Recommendations are given for the installation of temporary inventory supports for all spans of composite concrete floors when using corrugated sheets of 0.7–0.9 mm thickness for grade H75 according to GOST 24045–2016. The obtained data can be used in the design of composite concrete floor slabs and in the inspection of the technical condition of erected structures.
GEÇMİŞTEN GÜNÜMÜZE RAST MAKAMI
Authors: Aksoy Tugay , Bay Tolgahan , Murat Semih Burak
Published: November 2024

Türk müziği, 600'e yaklaşan makam çeşidiyle son derece zengin bir müzik geleneğine sahiptir. Kendine özgü yapısal ve karakteristik özelliklere sahip olan bu türün önemli bir özelliği de makamsal yapısının bulunmasıdır. Türk müziği, tarih boyunca çeşitli etkiler altında kalarak evrimleşmiş bir müzik geleneğini temsil eder. Makamlar da bu geleneğin önemli bir bileşeni olarak, zaman içinde çeşitli değişimlere ve dönüşümlere maruz kalmıştır. Bu çalışmada, Türk mûsikîsinde Rast makamının tarihi serüveni bilimsel bakış açısıyla ele alınmış, makamı oluşturan unsurlar işlenmiş ve bu değişimin daha net bir biçimde görülebilmesi için iki farklı döneme ait iki eser karşılaştırılarak analiz edilmiştir.
THE CITY POLICE OF SMOLENSK PROVINCEDURING THE NIKOLAYEV ERA: ISSUES OF PERSONNEL POLICY
Authors:   The Smolensk State University ( Russia), Chikov S.S.
Published: November 2024

The article analyses the personnel policy in the city police in Smolensk province in the second third of the XIX century. When considering the degree of study of the problem, special attention is paid to modern historiography. The source base of the research are the regulatory legal acts of the Russian Empire in the end of the XVIII century - the first half of the XIX century, the main block consisted of the records of the Russian State Archive of the Police Department as well as of the State Archive of the Smolensk region in the fonds of the Smolensk Governor's Office and the Gzhatsk city police. The analysis of legislative base and archival sources for the first time enabled the author to give an almost complete list of Smolensk policemen beginning from the foundation of the Office of Piety in Smolensk in 1804 to its abolition in 1862. The author reflects specific features of the personnel policy during Nikolaev's epoch by the example of Smolensk province and reveals the peculiarities of everyday life in the provincial towns in the second third of the 19th century. The author's conclusion is the thesis that Smolensk province reflects both strong and weak sides of the personnel policy of the Russian absolutism in the second third of the XIX century and, in this connection, serves as a representative example of the phenomenon.
Por uma história da população parda brasileira
Authors: Rodrigues Ozaias da Silva
Published: November 2024

Esta resenha tem por finalidade fazer uma análise crítica da obra Pardos: a visão das pessoas pardas pelo Estado brasileiro (2021), trazendo percepções particulares sobre o tema do livro. A metodologia se baseia em leitura bibliográfica sobre o assunto e discussão em eventos acadêmicos das Ciências Sociais e entre os pares da Antropologia. A relevância do tema se mostra pela renovação necessária do olhar sobre o tema que pesquisadores/as pardos/as propõem em suas pesquisas e obras, defendendo uma perspectiva positiva sobre o ser pardo no Brasil. O livro traz uma contribuição ao debate das relações étnico-raciais, sobretudo ao tentar traçar uma história da população parda brasileira, sendo que essa história se deslinda em sua relação com o Estado. Denis Moura dos Santos dialoga com obras das Ciências Sociais, da História, do Direito, da Educação, bem como com legislação e notícias jornalísticas sobre o tema. Entre outras coisas, conclui-se que é necessário levar a sério a particularidade da população parda brasileira, sem vinculá-la a outro grupo racial, sendo fundamental pensar os pardos a partir dos pardos e de suas experiências de racialização e discriminação. Como desdobramento da discussão, vê-se a necessidade de falarmos de caboclos e pardos-indígenas, enfatizando a diversidade parda no Brasil.