bluuebunny/crossref_metadata_2025 huggingface dataset:
Trends in obstetric care statistics in the Russian Federation
Authors: Bantieva M. N. , Manoshkina E. M. , Sokolovskaya T. A.
Published: December 2020

An analysis of obstetric care statistics, which are considered as an indicator of the population’s health both now and in the future, seems relevant.

Aim. To assess the dynamics of obstetric care data in Russia from 2006 to 2015 according to official statistics.

Material and methods. The official statistics were analyzed using the descriptive statistic methods.

Results. During the study period, the number of births in Russia increased by 30,1% and since 2012 has exceeded the level of 1991. We also revealed an increase in the prevalence of ectopic pregnancy (1,62-2,6% of all recorded pregnancies). A high level (~80%) of maternal morbidity over the past 6 years has remained. At the same time, there was a decrease in the incidence of maternal anemia, extragenital diseases, and gestosis. The prevalence of abnormal labor decreased over 10 years by 27,5% and amounted to 88,4 per 1,000 births in 2015, which is lower than in the 1991 (96,5‰). The incidence of labor bleeding decreased during the observation period by 11,4%. It is important that there was a decrease in the number of bleedings in the postpartum and postpartum period, and hemorrhages due to placenta previa and clotting disorder became more frequent. The number of caesarean sections has doubled over 10 years.

Conclusion. The analysis shows the favorable trends in reproductive statistics in Russia — a decrease in reproductive losses, certain complications of pregnancy and labor. At the same time, decrease in the number of vaginal delivery and a high incidence of bleeding and sepsis specifies ways to improve the obstetric care service.
Methodical tools of establishing strategic trends of regional and industrial development of the city
Authors: Rastvortseva S. N. , Minaeva I. N.
Published: December 2020

To establish a framework of strategic trends of regional and industrial development of a city system it is necessary to estimate the competitiveness level of the city and its industries. The authors present a method of assessment of the city’s competitiveness, based on the analysis of potentials available: economics, finance, labour resources, infrastructure, social sphere, demography. The level of development of certain types of economic activity (C, D, E) was estimated by the indicators of labour productivity, employment by economic activity and average monthly salary. The authors have created the “competitiveness of the city – sectoral interaction” matrix for the municipal system of the region. As a result of practical approbation they introduce the framework of strategic priority trends of regional and sectoral development of municipal system in Belgorod region in 2020–2025.
Opportunities and combinations of chinese "Belt and Road" initiative for national economies of Southeast Asia
Authors: Maslov A. A.
Published: December 2020

Initially, the Belt and Road initiative was greeted with enthusiasm in Southeast Asia, as it made possible to support projects and bring the products from Southeast Asia to international markets. However, the overwhelming number of projects in Indonesia, Malaysia, Laos, Philippines, and Thailand are experiencing significant difficulties,and none of them has been completed. China’s main volumes of investments and loans are allocated exclusively for infrastructure projects, while serious funds are not allocated for innovative industrial facilities or IT structures. Railroads and logistics facilities will be used to export Chinese goods to these countries, import raw materials to China, or deliver local industry products. The economic feasibility and quality of investments in projects in Indonesia and Malaysia are in great doubt. Laos and Myanmar are taking loans from China to develop the railway network without developing their own industry, so these regions can only be traders of Chinese goods. These countries cannot recoup the projects at all, many of them turn out to be unfinished, and therefore the debt to China is growing. The mega-project of the South China-Southeast Asia corridor was not economically sustainable. Its economic feasibility for the participating countries (except for China itself) raises many questions.
Transformation management in integrated entities on the basis of platform approach
Authors: Avdeeva I. L. , Golovina T. A. , Polyanin A. V. , Vertakova Yu. V.
Published: December 2020

At present integrated entities are facing tough competition at the global market. In order to make the functioning more efficient these entities ought to conduct regular and purposeful transformations of both business process and its organization.

Each economic system requires understanding how new technologies affect the existing markets and how to start the transformation to keep and strengthen the position.

The existing methods and mechanisms fail to balance the interests in a corporate structure during the participants’ integration and to consider the participants’ activity. They reveal the inefficiency of the existing mechanisms of development management of integrated entities in terms of digitalization, therefore it is necessary to find new approaches to transformation management of the systems in accordance with their complicated and multi-level character.

The analysis of methodology of transformation management process conducted by the authors shows significant discrepancy of digital tools, objectives and the efficiency level of the integrated entities’ management.

The authors come to the conclusion that the platform approach is both an optimizing technological solution and a powerful factor creating integrated economic environment which provides for gross product growth and increases labour productivity.

A platform integrated entity is one of the most successful innovations in creating business models in digital economy. Development and spreading of digital technologies will undoubtedly give ways for new business development opportunities.
Establishing the approach to sustainability assessment of a coal mining company’s activity
Authors: Velikoselskiy A. V. , Kluchnikova Yu. A.
Published: December 2020

High competition in the existing coal mining market has set up new landmarks in companies’ performance. Maintaining steady development of a coal mining business is the main task at all managerial levels and is supported by high sustainability level. A company’s ability to preserve stability is one of the key factors revealing stable development of a coal mining business. The need for establishing a system of a company’s sustainability indicators is determined by the necessity to estimate the company’s performance more accurately and in accordance with the objectives set. The authors of the article suggest a new complex approach to estimating a coal mining company’s sustainability. It is based on preserving stable operation under the influence of outer and inner risks. The authors explain the impact of various technical and economic indexes on a company’s activity, suggest formulas for calculating the assessment index – stability coefficient, define the limits for three areas by the value of the stability coefficient and the degree of risk elimination, calculate the sustainability of the company’s operation basing on the indicators’ actual values and the actions taken to eliminate risks per year. The approach suggested can become one of universal tools for analysis and assessment of current operation as well as for the medium-term planning. It can also be used in any coal mining company. The novelty of the approach is determined by the combination of traditional financial and economic analysis and the approach based on application of risk management system.
Turizm Yatırım Teşvikleri Çerçevesinde Antalya
Authors: MUTLU-KESİCİ Evla , BAŞER Gözdegül
Published: December 2020

Kamu yatırım teşvikleri; yatırım kararlarını yönlendiren, farklı bölgelere ve sektörlere verilebilen, çeşitli kapsamlardaki imtiyazlardır. Turizm alanında verilen desteklerden yüksek oranda faydalanan şehirlerden birisi de turizm potansiyeli yüksek olan Antalya ilidir. Bölgedeki mevcut teşvik talebini anlamak ve geleceğe yönelik öngörü kazanabilmek adına, bu çalışmada son beş yılda turizm alanında verilen yatırım teşvik listeleri incelenmiş ve konuyla ilgili görüşmeler yapılmıştır. Elde edilen sonuçlarına göre, Antalya’ya verilen turizm teşviklerinin yıllar içinde azaldığı, iptal edilen teşvikler açısından da Antalya’daki oranın diğer illerden daha yüksek olduğu anlaşılmıştır. Teşvik başvurularının azalması, işletmelere çeşitli avantajlar sağlayan kültür ve turizm koruma ve geliştirme bölgelerindeki doluluğun artması ile ilişkilendirilmiştir. Değişen turist profili de göz önünde bulundurularak, kitle turizminin dışında butik işletmeciliği de destekleyecek kapsamda bir teşvik planlamasına yönelik öneriler sunulmuştur. Bununla birlikte golf veya kırsal turizm gibi turizm türlerine odaklanan teşviklerin, potansiyeli yüksek ilçeler için arttırılmasının, bölgesel kalkınma açısından önemine değinilmiştir.
Restoran İşletmelerinde Rol Stresi ve Lider-Üye Etkileşiminin İşten Ayrılma Niyetine Etkisi
Authors: DEMİRCİ Barış , SEÇİLMİŞ Cihan
Published: December 2020

Araştırmanın amacı, rol stresi, lider-üye etkileşimi ve işten ayrılma niyeti arasındaki ilişkiyi belirlemek ve lider-üye etkileşiminin rol stresi ve işten ayrılma niyeti arasındaki ilişkiye aracılık etkisini ortaya koymaktır. Nicel araştırma yönteminin kullanıldığı bu çalışmada İstanbul’daki Turizm İşletme Belgeli restoran çalışanlarından (378) anket tekniğiyle veri toplanmıştır. Güncel istatistik programında analiz edilen verilerden elde edilen sonuçlar araştırmanın amacına uygun olarak yorumlanmıştır. Yapılan analizler sonucunda; rol stresi, lider-üye etkileşimi ve işten ayrılma niyeti arasında istatistiksel olarak anlamlı ilişkiler tespit edilmiş ve lider-üye etkileşiminin rol stresi ile işten ayrılma niyeti arasında kısmi aracılık etkisi olduğu belirlenmiştir. İşgören devir hızının yüksek olduğu yiyecek içecek sektöründe bu değişkenler arasındaki ilişkilerin ortaya konulması, işten ayrılan çalışanlarla ilgili ciddi maliyetlere katlanmak durumunda kalan yiyecek içecek işletmelerine çözüm önerisi sunacağı düşünülmektedir.
Criminological Problems of the Digital World (Digital Criminology)
Authors: Serebrennikova Anna
Published: December 2020

The development of information society and the corresponding technologies raises to a new level the tasks of counteracting crimes committed using such technologies, and of minimizing damage from them. The growth in the scale of new types of crime is a cause of worry for the society and the authorities, and especially for criminologists, as the penetration of criminals into the virtual environment and their mastery of new technologies acquire dangerous forms, change criminal motivation and, at the same time, to some extent stimulate the development of information and telecommunication technologies. The growing sophistication of the tasks of preventing and counteracting hi tech crimes makes it necessary to critically assess the current criminological methods and to make an attempt to go beyond the known «common» methods of neo-classical criminology. The development of the digital criminology concept cannot be reduced to an aggregate of pioneer technological methods developed on the basis of mathematical modeling, i.e. computer processing of quantitative and qualitative parameters of crimes, mathematical detection of different dependencies (on time, place and other variables), it could and should be understood in a wider sense: on the one hand, it should influence the new criminological paradigm, and on the other - it should develop within its boundaries. The modern information-analytical sphere in the work of law enforcement bodes includes the use of digital criminological instruments within the programs of crime prevention, mathematical methods of analyzing crimes, profiling, etc. Their aggregate is generally applicable to criminological analysis and prediction, however, it does not have the most cutting edge theoretical basis that corresponds to the tasks of counteracting crimes of the digital world; it is now being formed on the basis of criminological neo-classics, the advances of the social sciences and the humanities, digital criminology. The predictions of new industrial revolutions include a rapid acceleration of the pace of technological development, a systemic transformation of production and management, which will not only stimulate a global rise in the living standards, but will also increase inequality and, consequently, will provide an impetus to crime. These aspects should be taken into consideration when predicting future development of digital criminology, whose theories should be based on the conceptual models of social development of the near future. Social consequences of the predicted new industrial revolutions will inevitably become new common determiners of the crimes of the future, as it always happened in the past.
Criminological and Criminalistic Problems of Overcoming the Counteraction to Criminal Prosecution
Authors: Garmaev Yury , Dmitry Kim
Published: December 2020

The authors analyze the history of the emergence and development of the corresponding criminological research and special criminalistic theory of overcoming the counteraction to criminal prosecution (preliminary investigation) to research its present condition, examine its potential for improving the effectiveness of fighting crime while strictly observing the rights and lawful interests of citizens. The authors use systemic, interdisciplinary and situational approaches, the methods of comparative jurisprudence and a number of sociology methods to update the current (to speak conventionally, accusatory) paradigm of the theory. The essence of this update (the new concept) is to ensure the adversarial nature of the judicial process, as well as in other types of court procedures, for the prosecution and the defense. The presented theory concept includes the idea that counteraction to prosecution could be not only unlawful and amoral, but also lawful and ethically admissible. The motives of persons involved in this counteraction could include their subjective confidence in their total or partial innocence, as well as the unlawful and (or) amoral, in that persons opinion, actions of some law enforcement employees. These clauses are developed through the authors own definition of counteraction and the classification of its acts. They have formulated six theses that form the basis of the updated paradigm of the theory. The authors conclude that the presented research approach, the concept reflected in the didactics of university law schools, could instill in students and practitioners a deep and stable personal motivation to study not only the corresponding academic disciplines, but the whole criminalistics and criminology as well as other theories and disciplines of the anti-criminal cycle. The suggested approach and the practical recommendations based on it could be used in the conceptually new syllabus (and subjects) already taught in the leading Russian universities, like «Counteracting Crime», «Criminalistic Support of Business Security», «Tactics of Protection against Unlawful Actions of Government Employees», «Tactics of Interaction between Business Structures and Controlling Bodies».
On the Scope of Criminalistic Habitoscopy in the Implementation of Measures Against Modern Cyber Crime
Authors: Protasyevich Alexander , Foygel Elena
Published: December 2020

The article presents an overview of modern possibilities of criminalistic habitoscopy in the conditions of global digitization. Methodological recommendations on the investigation and solution of cybercrimes should have a serious research and methodological basis, and criminalistic habitoscopy could provide such a basis. In the situation of global digitization and the use of virtual channels of communication (video conference calls), the characteristics of a persons outward features should include perceptibility, or the ability of the subject of perception (human sense organs or technical devices) to identity specific features of that persons look. In connection with this, the authors claim that a persons outward features are a complex system of elements that together form his or her appearance - an image that is visually perceived by other people or by devices. Taking into account the perceptibility of a persons outward look, his or her general physical features, besides the traditional ones, will include the geometry of hands, the vein structure on palm surfaces, finger thermogram, face and skull geometry, etc., all of which have a high criminalistic value. However, considering the current sanitary and epidemiology measures undertaken in Russia (wearing medical masks and gloves), climate (covering faces with scarves and kerchiefs) and cultural (women wearing national clothes that cover their faces, men with stubble or a beard) specifics, as well as the methods of falsifying anatomical features and counteracting criminalistic technologies already developed by the criminals, the authors view the research of the dynamic characteristics of a persons outward appearance in the form of digital behavior as the most perspective area. These characteristics primarily concern stylometry (keyboard handwriting) - a set of dynamic characteristics of pressing keys on a computer keyboard, which includes a system of subconscious automatic actions habitual to the user. Besides, the most relevant features of digital behavior should include digital handwriting, gestures, facial expression and lip movement.
On the Tactical and Forensic Potential of Investigative Examination in the System of Crime Counteraction Measures in the Sphere of Land Relations
Authors: Vardanyan Akop , Vardanyan Galina
Published: December 2020

The authors analyze the influence that the liberalization of land relations had on the rise of new trends in the structure of crime, on the emergence of a specific «criminal market» of land that was seized though seemingly legal actions regulated by the dacha amnesty legislation with a simplified procedure for registering the right of ownership of land plots allocated for gardening, growing vegetables and personal farming before the Land Code of the Russian Federation came into force in 2001. Based on the study of representative empirical sources, the authors analyze different criminalistically relevant features of crime in this sphere that make it possible to implement the criminal intent of transferring (sometimes, serial transferring) of the right of ownership of land plots. Although the cornerstone of these actions lies in obtaining the state registration certificate of the ownership of the land plot in the name of interested persons, which determines the necessity of the criminalistic research of the corresponding title and title confirmation documents (primarily, through their thorough examination with the elements of criminalistic analysis), a no less significant role in determining the aggregate of circumstances of these actions is played by the inspection of the scene. Unfortunately, in practice there is not enough attention paid to this investigative action: the examination of the scene either does not happen at all or is of nominal and declarative character, its high tactical potential is not fully utilized, which weakens the body of evidence for the criminal cases. This situation motivated the authors to present their criminalistic recommendations on improving the effectiveness of the inspection of the crime scene as a valuable source of evidentiary information in criminal cases in the sphere of land relations.
Trends of incidence and prognosis of upper tract urothelial carcinoma
Authors: Wu Jianping , Chen Shuqiu , Wu Xiaoli , Mao Weipu , Wang Yali , Xu Bin , Zheng Donghui , Chen Ming
Published: December 2020

The purpose of this study was to investigate trends in the incidence of upper tract urothelial carcinoma (UTUC) in patients and to establish a reliable and practical nomogram based on significant clinical factors to predict the overall survival (OS) and cancer-specific survival (CSS) of UTUC patients. The Surveillance, Epidemiology, and End Results (SEER) database was used to extract data on UTUC patients between 1988 and 2015. Incidence was calculated using Joinpoint regression software, and trends were quantified by annual percentage change (APC). A nomogram was constructed using R software to predict the OS and CSS probabilities for individual patients. From 1988 to 2015, the incidence of UTUC showed a downward trend (1988: 1.57/100,000 to 2015: 1.51/100,000; APC=-0.1). After stratification according to sex, age and primary site, we found that the incidences of UTUC in males, patients 70+ years old and the renal pelvis were higher than those in females, patients <70 years old and ureter cancer patients. In the training cohort, the nomogram established based on multivariate Cox regression results showed better OS and CSS accuracy (OS: C-index=0.701, AUC=0.736; CSS: C-index=0.729, and AUC=0.688) than SEER stage. In addition, the calibration curves showed good consistency between the predicted and actual 3-, 5- and 10-year OS and CSS rates of the nomogram. In the past 30 years, the incidence of UTUC has shown a general downward trend, and the prognostic nomogram we established can provide a personalized risk assessment for the survival of UTUC patients.
Prehospital sudden death from acute myocardial infarction in Tomsk (1984 and 2018): what has changed for 34 years
Authors: Okrugin S. A. , Lvova A. B. , Repin A. N.
Published: December 2020

Aim. To compare the circumstances of the prehospital deaths among patients with acute myocardial infarction (AMI) in Tomsk in 1984 and 2018.

Methods. Population-level data were collected from the WHO project “Acute Myocardial Infarction Registry”. In 1984, 739 cases of AMI were recorded, in 2018 - 924 ones. 262 (35.5%) and 359 (38.9%) deaths occurred in the acute phase, respectively. Of them, 158 (60.3%) and 148 (41.2%) patients died in the prehospital setting. 66 (41.8%) and 46 (31.1%) cases of deaths were selected for further analysis.

Results. In 2018, the number of patients who did not receive timely medical care decreased from 74.2% to 52.2%, compared to 1984 (p <0.05). The number of cases when patients failed to call the ambulance due to a rapid loss of consciousness (cardiac arrest) or managed to call, but died before the ambulance arrived, was similar. The number of death among patients who received emergency medical services (EMS) increased from 25.8% to 47.9% (p <0.05).

Conclusion. Prehospital mortality from AMI in Tomsk has improved over thirty years, but not drastically. Despite the number of patients who died before the first medical contact has decreased, they still make up about half of all cases. Every 4th-5th patient fails to contact EMS. In terms of reducing prehospital mortality, measures focused on the regular clinical examination of patients with cardiovascular diseases seem to be more promising for effective secondary prevention of coronary artery disease and AMI.
Scientometrics — a need or a fashionable trend?
Authors: Zemlyanoy Vyacheslav P. , Sigua Badri V. , Melnikov Vyacheslav A. , Lyubimov Nikolay G.
Published: December 2020

The papaer presents a review of some publications on the history of the development, formation, functions and capabilities of scientometrics, as well as the state of Russian science and its role on the international arena. The thoughts regarding the role of scientometrics in modern scientific research are stated. To date, scientometrics provides a number of possibilities. First of all, it is a system for monitoring publication activity of scientists around the world. Obviously, the main goal is structuring scientific publications with the following improvement of scientific activity. Howewer, are modern scientometric indicators objective in relation not only to the number, but also to the quality of scientific publications? Is the notorious Hirsch index an ideal parameter for evaluating the performance of researchers? Are there any prospects for scientometrics in the modern scientific world, or is a worthy alternative to currently used methods for assessing scientific activity required? These and many other questions are raised by the authors in this article.
Secondary risk factors of sudden cardiac death and genes of arterial hypertension
Authors: Kachnov Vasilii A. , Tyrenko Vadim V. , Kolyubaeva Svetlana N. , Myakoshina Lilia A. , Buntovskaya Alexandra S.
Published: December 2020

Purpose. To study the influence of polymorphisms of arterial hypertension genes and their various combinations on individual risk factors of sudden cardiac death.
Materials and methods. 319 young people from 18 to 24 years of age who are entering military service by conscription were examined. The survey identified 69 individuals with signs of increased risk of sudden cardiac death after being examined for secondary risk factors of sudden cardiac death and taken a blood test to determine the polymorphisms of the genes AGT 521 CT, GNB3 825 CT, CYP11B2 344 CT, NOS3 786 TC.
Results. The greatest influence on the severity of secondary risk factors was exerted by the following variants of a combination of gene polymorphisms: AGT 521 CT and NOS3 786 TC in the individuals with a heterozygous risk variant, both genes showed a significant increase in the duration of the corrected QT interval, heart rate, and a decrease in heart rate variability. AGT 521 CT and CYP11B2 344 CT homozygous risk variant of the CYP11B2 344 CT and the heterozygous risk variant AGT 521 CT is associated with a longer duration of the corrected QT interval, and the heterozygous risk variant for both genes is associated with higher heart rate values. AGT 521 CT and GNB3 825 CT combination of a homozygous risk variant of the gene GNB3 825 CT and the heterozygous variant of the gene AGT 521 CT is associated with the greatest effect on a heart rate.
Conclusions. The presence of a homozygous risk variant of the gene NOS3 786 TC, a heterozygous risk variant of the gene GNB3 825 CT is prognostically unfavorable for its effect on the severity of secondary risk factors for sudden cardiac death. The combination of the heterozygous variant AGT 521 CT with a heterozygous variant of NOS3 786 TC and a homozygous risk variant by the gene CYP11B2 344 CT and the heterozygous risk variant AGT 521 CT are also the most unfavorable in terms of its effect on secondary risk factors for sudden cardiac death. Secondary risk factors of sudden cardiac death are influenced by both individual polymorphisms of genes of arterial hypertension, and their various combinations.
Features of profiling methods for the expression of long non-coding RNAs in tumors
Authors: Beylerli Ozal Arzuman A. , Gareev Ilgiz F. , Izmailov Adel , Lipatov Oleg N.
Published: December 2020

With rapid advances in high-performance genome analysis technology, studying of long non-coding RNAs (lncRNAs) has become a very popular topic in biomedical research. LncRNAs are a group of non-coding RNAs with a length of more than 200 nucleotides. LncRNAs play a fundamental role in cell proliferation and differentiation, and epigenetic regulation. Thus, studying lncRNAs will give a new understanding of gene regulation and will open up new possibilities for treating and diagnosing many diseases, including tumors. The identification of new molecular markers in the form of circulating lncRNAs will improve tumor detection, predicting the course of the disease, treatment planning, and diagnosing at the earliest signs of upcoming neoplastic transformation. Treatment of tumors, especially malignant ones, is also a difficult task. When surgery and chemotherapy are not effective, radiation therapy becomes the treatment of choice. Therefore, the possibility of lncRNAs being innovative therapeutic agents in tumors is a viable idea. However, the possibility of their use in modern clinical practice is limited due to the number of problems associated with significant differences between procedures for processing samples, methods of analysis, and especially strategies for standardizing results. Another problem for conducting studies on the profiling of lncRNAs expression is their large number and the diversity of their functions in tumors. Therefore, the solution of technological problems on the profiling of lncRNAs expression in tumors may open up new possibilities for the use of lncRNAs in modern clinical practice.
Cutaneous manifestations of ANCA-associated vasculitis and immunosuppressive therapy: cause-effect relationships (a case report)
Authors: Kitova Madina A. , Maksimov Maksim V. , Marchenko Valeriy N. , Bruchkus Elena A. , Davydov Denis A.
Published: December 2020

Granulomatosis with polyangiitis, formerly known as Wegeners granulomatosis, is an autoimmune ANCA-associated systemic vasculitis characterized by extensive damage to multiple organs and systems. Besides a typical clinical triad of ENT, lungs, and kidneys injury, various types of skin lesions can be found in 1050% of cases. A severe course of the disease and low survival of patients often requires using aggressive treatment in a form of combined immunosuppressive therapy. On the one hand, it generally improves the prognosis, and on the other is itself associated with numerous complications. One of them is a secondary infection. Skin is the second most common localization of infection after the respiratory system. Preceding skin lesions caused by vasculitis may increase the risk of infection. Thus, patients with ANCA-associated vasculitis should be carefully observed for cutaneous manifestation, both before and during the immunosuppressive therapy.
Features of the course of rheumatoid arthritis and osteoarthritis in patients with asymptomatic hyperuricemia
Authors: Mazurov Vadim I. , Bashkinov Roman A. , Fonturenko Alexandra Yu. , Gaydukova Inna Z. , Petrova Marianna S. , Inamova Oksana V. , Nagirnyak Ivan M.
Published: December 2020

Introduction. According to numerous studies, the prevalence of asymptomatic hyperuricemia has increased in most countries. Uric acid is an important biomarker of the cardiovascular system, and there are now quite a big number of sources indicating its role in the development of a some chronic metabolic conditions, cardiovascular disease and associated mortality. At present, there is no consensus on the need for urate-lowering therapy in patients with asymptomatic hyperuricemia. There is a limited number of studies examining the problem of asymptomatic hyperuricemia in patients with rheumatic diseases, the features of comorbidity in these conditions, the frequency and effectiveness of urate-lowering therapy.
Purpose. To study the peculiarities of the course of rheumatoid arthritis and osteoarthritis with associated asymptomatic hyperuricemia and compare them with the ones associated with arthragra.
Materials and methods. The analysis was performed on the basis of the data collected from the city register of the patients with arthragra and asymptomatic hyperuricemia in St. Petersburg. The data collected included the medical records of 1725 patients with arthragra, 433 patients with rheumatoid arthritis and hyperuricemia and 355 patients with osteoarthritis and hyperuricemia.
Results. The patients with rheumatoid arthritis and hyperuricemia were more likely to have increased erythrocyte sedimentation rate and C-reactive protein, the highest medium level of erythrocyte sedimentation rate; acute myocardial infarction, chronic heart failure, gallstone disease and non-alcoholic fatty liver disease were more frequently detected. The patients with osteoarthritis and hyperuricemia were more likely to have high total cholesterol, at its highest medium level; stable angina, arrhythmia, varicosity, obesity, prediabetes and type 2 diabetes mellitus were more likely to be detected. Kidney damage was detected more frequently in the patients with arthragra. In the group of rheumatoid arthritis and hyperuricemia urate-lowering therapy was started in 30.95% of the patients, in the group of osteoarthritis and hyperuricemia in 36.06%.
Conclusions. In rheumatic diseases, hyperuricemia is a common associated condition. Their combination leads to increased risk and frequency of cardiovascular, metabolic and gastroenterological comorbidity. The prescription of urate-lowering therapy to the patients with rheumatic diseases and asymptomatic hyperuricemia with high cardiovascular risk led to the target uric acid levels in 34.58% of the patients with rheumatoid arthritis and 52.08% of the patients with osteoarthritis.
How CT reconstruction parameters effect measurement error of pulmonary nodules volume
Authors: Alderov Zaur A. , Rozengauz Evgeny V. , Nesterov Denis
Published: December 2020

One of the the widely used way to follow up oncological disease is estimation of lesion size differences. Volumetry is one of the most accurate approaches of lesion size estimation. However, being highly sensitive, volumetric errors can reach 60%, which significantly limits the applicability of the method.
Purpose was to estimate the effect of reconstruction parameters on volumetry error.
Materials and methods. 32 patients with pulmonary metastases underwent a CT scanning with 326 foci detected. 326 pulmonary were segmented. Volumetry error was estimated for every lesion with each combination of slice thickness and reconstruction kernel. The effect was measured with linear regression analysis
Results. Systematic and stochastic errors are impacted by slice thickness, reconstruction kernel, lesion position and its diameter. FC07 kernel and larger slice thickness is associated with high systematic error. Both systematic and stochastic errors decrease with lesion enlargment. intrapulmonary lesions have the lowest error regardless the reconstruction parameters.
Lineal regression model was created to prognose error rate. Model standart error was 6.7%. There was corelation between model remnants deviation and slice thickness, reconstruction kernel, lesion position and its diameter.
Conclusion. The systematic error depends on the focal diameter, slice thickness and reconstruction kernel. It can be estimated using the proposed model with a 6% error. Stochastic error mainly depends on lesion size.
Kronik hepatit C tedavisinde ikinci kuşak direk etkili oral antivirallerin gerçek yaşam verileri: Tek merkez ve heterojen hasta grubu
Authors: AKAR Mustafa , SOLAKOĞLU Tevfik
Published: December 2020

Giriş ve Amaç: Kronik hepatit C enfeksiyonu karaciğer sirozu ve hepatoselüler karsinomun nedenleri arasındadır. Bu çalışmada primer olarak kronik hepatit C’li heterojen bir hasta grubunda güncel olarak kullanılan ikinci kuşak direk etkili oral antivirallerin tedavi etkinliği ve yan etki profillerinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Retrospektif olan bu çalışmaya ikinci kuşak direk etkili oral antiviral tedavi alan 72 hasta dahil edilmiştir. Hastalara ait klinik ve laboratuvar verileri poliklinik takip dosyalarından elde edilmiştir. Bulgular: Hastaların yaş ortalaması 58±14 olup, 39’u (%54) kadın idi. Baskın genotip 1b idi (%74.6). Non-sirotik, kompanse siroz ve dekompanse siroz hastaların sayıları sırasıyla; 56 (%77.8), 14 (%19.4) ve 2 (%2.8) idi. On sekiz hasta (%25) tedavi deneyimli idi. Paritaprevir/ritonavir/ombitasvir + dasabuvir, ledipasvir/sofosbuvir, ledipasvir/sofosbuvir + ribavirin, sofosbuvir + ribavirin, glekaprevir + pibrentasvir ve paritaprevir/ritonavir/ombitasvir + ribavirin alan hasta sayıları sırasıyla; 38 (%52.8), 13 (%18.1), 7 (%9.7), 7 (%9.7), 6 (%8.3) ve 1 (%1.4) idi. Toplam 71 hasta tedaviyi tamamladı ve bunların 69’unda (%97.2) kalıcı viral yanıt elde edildi. Ayrıca başlangıç aspartat aminotransferaz, alanin amimotransferaz, gama glutamil transferaz ve alfa fetoprotein düzeylerinde tedavi ile birlikte anlamlı bir düşüş izlendi (p
FINITE ELEMENT SOLUTION OF HYDROMAGNETIC MIXED CONVECTION IN A NANOFLUID FILLED VENTED GROOVED CHANNEL
Authors: ALİ Mohammad Mokaddes , ALİM Md. Abdul Alim , AHMED Syed Sabbir
Published: December 2020

The mixed convection flow in a differentially heated grooved channel filled with water based nanofluid under the influence of external magnetic field has been analyzed numerically in this study. Nanofluid’s thermal conductivity model has been modified to develop a new physical problem and finite element method has been implemented to solve the dimensionless governing equations. Numerical simulations have been performed for different values of pertinent parameters. Fluid flow and temperature distributions have been exhibited in terms of streamlines and isotherms due to the variation of Richardson number, Hartmann number and concentration of nanoparticles in base fluid water. The results show that flow field and temperature distributions within the channel affected significantly with the effects of Richardson number, Hartmann number and concentration of nanoparticles. In addition, it is found that heat transfer rate increases and decreases respectively with the increase in strength of magnetic field which depends strongly on Richardson number. Moreover, heat transfer rate accelerates effectively for increasing volume fraction, Reynolds number and Richardson number. The present simulation has been validated by comparing the present results with other published works on the basis of special cases.
Avaliação do potencial de mitigação das mudanças climáticas com o uso de colmos de bambu na construção civil brasileira
Authors: Caldas Lucas Rosse , Rodriguez Leonardo , Menezes Bruno , Toledo Filho Romildo
Published: December 2020

Dentre os materiais não convencionais utilizados na construção civil, o bambu apresenta potencial de aplicação devido suas propriedades mecânicas, rápido crescimento, baixo custo, grande disponibilidade e capacidade de sequestro e armazenamento de CO2. Este trabalho teve o objetivo de avaliar o potencial de redução do impacto de mudanças climáticas com o uso de colmos de bambu aplicados em habitações. Para isso foi utilizada a metodologia de Avaliação do Ciclo de Vida Dinâmica (ACVd). A unidade funcional escolhida foi: “1 metro de colmo Phyllostachys pubescens com resistência à compressão mínima de 46 MPa e vida útil de dois anos”. Foram quantificadas as emissões de gases de efeito estufa nas etapas de plantio, corte, tratamento e transporte dos colmos para diferentes localidades do país. Foram considerados diferentes cenários de fim de vida: (1) reciclagem, (2) aterramento (3) incineração. Os dados de produção dos colmos foram cruzados com o futuro déficit habitacional brasileiro, adotando a aplicação dos colmos como escoras para a construção de habitações. Ao final da pesquisa foi possível mapear quais as regiões brasileiras são as mais indicadas para o uso desses colmos de bambu. O uso de colmos como escoras para a superação do déficit habitacional brasileiro, entre os anos de 2020 e 2040 pode resultar em -0,10 MtCO2-eq (Reciclagem) a +0,08 MtCO2-eq (Incineração). Para os cenários de emissão negativa, o uso de colmos de bambu pode ser enxergado como uma estratégia de compensação climática, sendo, portanto, uma justificativa importante para o incentivo do bambu no setor da construção civil
Brigada Sanitaria Adriana Haidar: solidaridad técnica montonera con la revolución sandinista
Authors: Cortina Orero Eudald
Published: December 2020

La revolución sandinista recibió la solidaridad de diferentes contingentes internacionalistas que apoyaron el esfuerzo insurreccional del Frente Sandinista de Liberación Nacional (FSLN) y participaron de la consolidación del proyecto revolucionario y la reconstrucción de Nicaragua. Este artículo estudia el caso inédito de la Brigada Sanitaria Adriana Haidar, estructura conformada en México por el Movimiento Peronista Montonero (MPM). Abordamos esta experiencia centrándonos en cuatro aspectos. Rastreamos, primero, las redes transnacionales generadas por Montoneros entre 1974 y 1979. Identificamos, en segundo lugar, los aportes efectivos del contingente y las proyecciones solidarias de esta experiencia. En tercer lugar, analizamos el impacto en términos personales y militantes sobre los integrantes de la Brigada. Y, finalmente, enmarcamos estas experiencias internacionalistas en las dinámicas organizativa de Montoneros en este periodo, marcadas por la llamada Contraofensiva Estratégica, que tuvo como objetivo el retorno escalonado de militantes montoneros a Argentina para combatir a la dictadura militar.
On the Modeling of Sequential Reactive Systems by Means of Real Time Automata
Authors: Vinarskii Evgeney Maximovich , Zakharov Vladimir Anatolyevich
Published: December 2020

Sequential reactive systems include hardware devices and software programs which operate in continuous interaction with the external environment, from which they receive streams of input signals (data, commands) and in response to them form streams of output signals. Systems of this type include controllers, network switches, program interpreters, system drivers. The behavior of some reactive systems is determined not only by the sequence of values of input signals, but also by the time of their arrival at the inputs of the system and the delays in computing the output signals. These aspects of reactive system computations are taken into account by real-time models of computation which include, in particular, realtime finite state machines (TFSMs). However, in most works where this class of real-time automata is studied a simple variant of TFSM semantics is used: the transduction relation computed by a TFSM is defined so that the elements of an output stream, regardless oftheir timestamps, follow in the same order as the corresponding elements ofthe input stream. This straightforward approach makes the model easier to analyze and manipulate, but it misses many important features of real-time computation. In this paper we study a more realistic semantics of TFSMs and show how to represent it by means of Labeled Transition Systems. The use of the new TFSM model also requires new approaches to the solution of verification problems in the framework of this model. For this purpose, we propose an alternative definition of TFSM computations by means of Labeled Transition Systems and show that the two definitions of semantics for the considered class of real-time finite state machines are in good agreement with each other. The use of TFSM semantics based on Labeled Transition Systems opens up the possibility of adapting well known real-time model checking techniques to the verification ofsequential reactive systems.
Temporal Logic for Programmable Logic Controllers
Authors: Garanina Natalia Olegovna , Anureev Igor Sergeevich , Zyubin Vladimir Evgenyevich , Staroletov Sergey Mikhailovich , Liakh Tatiana Victorovna , Rozov Andrey Sergeevich , Gorlatch Sergei Petrovich
Published: December 2020

We address the formal verification of the control software of critical systems, i.e., ensuring the absence of design errors in a system with respect to requirements. Control systems are usually based on industrial controllers, also known as Programmable Logic Controllers (PLCs). A specific feature of a PLC is a scan cycle: 1) the inputs are read, 2) the PLC states change, and 3) the outputs are written. Therefore, in order to formally verify PLC, e.g., by model checking, it is necessary to describe the transition system taking into account this specificity and reason both in terms of state transitions within a cycle and in terms of larger state transitions according to the scan-cyclic semantics. We propose a formal PLC model as a hyperprocess transition system and temporal cycle-LTL logic based on LTL logic for formulating PLC property. A feature of the cycle-LTL logic is the possibility of viewing the scan cycle in two ways: as the effect of the environment (in particular, the control object) on the control system and as the effect of the control system on the environment. For both cases we introduce modified LTL temporal operators. We also define special modified LTL temporal operators to specify inside properties of scan cycles. We describe the translation of formulas of cycle-LTL into formulas of LTL, and prove its correctness. This implies the possibility ofmodel checking requirements expressed in logic cycle-LTL, by using well-known model checking tools with LTL as specification logic, e.g., Spin. We give the illustrative examples of requirements expressed in the cycle-LTL logic.
On the Model Checking Problem for Some Extension of CTL*
Authors: Gnatenko Anton Romanovich , Zakharov Vladimir Anatolyevich
Published: December 2020

Sequential reactive systems include programs and devices that work with two streams of data and convert input streams of data into output streams. Such information processing systems include controllers, device drivers, computer interpreters. The result of the operation of such computing systems are infinite sequences of pairs of events of the request-response type, and, therefore, finite transducers are most often used as formal models for them. The behavior of transducers is represented by binary relations on infinite sequences, and so, traditional applied temporal logics (like HML, LTL, CTL, mu-calculus) are poorly suited as specification languages, since omega-languages, not binary relations on omega-words are used for interpretation of their formulae. To provide temporal logics with the ability to define properties of transformations that characterize the behavior ofreactive systems, we introduced new extensions ofthese logics, which have two distinctive features: 1) temporal operators are parameterized, and languages in the input alphabet oftransducers are used as parameters; 2) languages in the output alphabet oftransducers are used as basic predicates. Previously, we studied the expressive power ofnew extensions Reg-LTL and Reg-CTL ofthe well-known temporal logics oflinear and branching time LTL and CTL, in which it was allowed to use only regular languages for parameterization of temporal operators and basic predicates. We discovered that such a parameterization increases the expressive capabilities oftemporal logic, but preserves the decidability of the model checking problem. For the logics mentioned above, we have developed algorithms for the verification of finite transducers. At the next stage of our research on the new extensions of temporal logic designed for the specification and verification of sequential reactive systems, we studied the verification problem for these systems using the temporal logic Reg-CTL*, which is an extension ofthe Generalized Computational Tree Logics CTL*. In this paper we present an algorithm for checking the satisfiability of Reg-CTL* formulae on models of finite state transducers and show that this problem belongs to the complexity class ExpSpace.
Knowledge-based Algorithms for BDI-agents
Authors: Shilov Nikolay Vyacheslavovich , Garanina Natalia Olegovna
Published: December 2020

Multiagent algorithm is a knowledge-based distributed algorithm that solves some problems by means of cooperative work of agents. From an individual agent's perspective, a multiagent algorithm is a reactive and proactive knowledge/believe-based rational algorithm aimed to achieve an agent's own desires. In the paper we study a couple of knowledge-based multiagent algorithms. One particular algorithm is for a system consisting of agents that arrive one by one (in a non-deterministic order) to a resource center to rent (for a while) one of available desired resources. Available resources are passive, they form a cloud; each of the available resources is lent on demand if there is no race for this resource and returns to the cloud after use. Agents also form a cloud but leave the cloud immediately when they rent a desired resource. The problem is to design a knowledge-based multiagent algorithm, which allows each arriving agent eventually to rent some of desired resources (without race for these resources).