bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification and Verification of an Alternative Polyadenylation-Related lncRNA Prognostic Signature for Glioma
Authors: Wang Hui , Jiang ZhiJun
Published: September 2022

Due to the high mortality and modality of glioma, it was urgently needed to develop a glioma prognostic assessment system. Previous studies demonstrated that alternative polyadenylation- (APA-) related genes are important in immune response and oncogenesis. mRNA and lncRNA expression information of glioma samples were acquired from CGGA and TCGA databases, and lncRNAs associated with APA were selected through correlation analysis. The prognosis model of APA-related lncRNAs was built by the univariate Cox, random forest, and univariate Cox regression analyses. Glioma samples were assigned into high- and low-risk groups. Independence and effectiveness of the prognostic model were evaluated by Kaplan-Meier analysis, ROC curve, and Cox regression analyses. GO, KEGG enrichment, and GSEA analyses showed that the mainly involved signaling pathways were enriched in cellular immunity and immune signal transduction. We further analyzed expression differences of negative immune regulatory genes and immune cell infiltration degree between two groups. Immune checkpoints CTLA4 and LAG3 and immune suppressors TGFB, IL10, NOS3, and IDO1 and immune cell infiltration were notably upregulated in the high-risk group. The PD1/PDL1 expression was significantly correlated with risk score, showing that the prognostic model of APA-related lncRNA could effectively assess the tumor immune suppression. In conclusion, we established a risk assessment model of APA-related lncRNA in glioma, which could effectively evaluate prognosis of patients with glioma and tumor immune suppression and could provide guidance for clinical treatment.
Risk Factors of Urinary Pathogenic Bacteria Infection after Benign Prostatic Hyperplasia Surgery and Curative Effect Analysis of Shuangdong Capsule Intervention
Authors: Xu Bing , Liu Ming , Liu Yonghui , Zuo Jianhong
Published: September 2022

Benign prostatic hyperplasia (BPH) is a common and frequently occurring disease in clinics, with the main manifestations including frequent micturition, urinary incontinence, dysuria, and endless urination. Transurethral resection of the prostate (TURP) is the main treatment for BPH, but some patients are prone to urinary tract infection after surgery, which affects the prognosis. Therefore, it is of great significance to study the pathogenic characteristics and risk factors of postoperative urinary-derived pathogenic bacteria infection in patients with BPH for the prevention and treatment of postoperative infection. In addition, the treatment of patients with this disease is also the focus of clinical attention. Long-term massive application of antibiotics can induce drug-resistant mutations of bacteria, so it is urgent to find an efficient and safe therapeutic scheme in clinics. However, traditional Chinese medicine (TCM) has a long history of treating urinary tract infections. Therefore, Shuangdong capsule, a traditional Chinese medicine preparation, was selected for the combined treatment in this study. The results showed that age, concomitant diabetes mellitus, and preoperative prophylactic application of antibiotics were the independent risk factors for postoperative urine-derived pathogenic infection in BPH patients. Clinical intervention for BPH patients with concomitant risk factors should be emphasized in clinical practice. The combined use of Shuangdong capsule and conventional western medicine can improve the clinical symptoms and inflammatory reactions of postoperative urine-derived pathogenic infection in BPH patients. Due to its exact curative effect and high safety, it is worthy of promotion. The clinical study registration number is M2022019.
Fuzzy Data Mining and Bioinformatics Analysis in Methylation Analysis of M6A Gene Promoter Region in Esophageal Cancer
Authors: Wu Shuoming , Yang Xiangbao , Qiu Xie , Pan Yinpeng
Published: September 2022

This work was aimed at analyzing the correlation between the methylation level of the M6A gene in esophageal cancer (EC) and the prognosis of patients based on bioinformatics technology and evaluating the prognostic predictive values of different data mining models. 80 EC patients and 80 healthy people were selected, and the serum of the patients was collected to detect the level of DNA methyltransferase. During the radical resection of EC, tumor tissues and adjacent normal tissues were collected from patients to detect the methylation level of the M6A gene. COX regression analysis was employed to analyze the independent risk factors (IRFs) of M6A gene methylation and other treatments affecting the prognosis of EC patients. The particle swarm optimization (PSO) algorithm was introduced to improve the fuzzy

C

-means clustering (FCM) algorithm. The differences in the prognostic prediction efficiency of logistic regression analysis (LRA), decision tree (DT) C5.0, artificial neural network (ANN), support vector machine (SVM), and improved FCM (IFCM) models were compared. The levels of DNA methyltransferase and human histone deacetylase 1 (HSD-1) in EC patients were increased greatly (

P
<
0.05

). The methylation rates and methylation levels of M6A methylation regulators (ALKBH5, HNRNPC, METTL3, WTAP, RBM15, YTHDC1, YTHDF1, and FTO) in EC tissues were obviously higher (

P
<
0.05

). The survival time of high-risk EC patients was much shorter than that of low-risk patients (

P
<
0.05

). Univariate and multivariate COX regression analysis showed that gender, tumor grade, TNM grade, degree of infiltration, and methylation of ALKBH5, HNRNPC, and METTL3 genes were IRFs for the prognosis of EC patients (

P
<
0.05

). The areas under the ROC curve (AUCs) of LRA, DT C5.0, ANN, SVM, and IFCM algorithms for predicting the prognosis of patients were 0.813, 0.857, 0.895, 0.926, and 0.958, respectively, and the IFCM model had the best diagnostic effect. In conclusion, the detection of bioinformatics technology showed no obvious DNA methylation in EC patients, and the elevated levels of M6A methylation regulators in patients were an IRF affecting the prognosis of patients. In addition, the fuzzy data mining model can be undertaken as the preferred method for prognosis prediction of EC patients.
Microarticstructural, Spectroscopic, and Magnetic Analysis of Multiwalled Carbon Nanotubes Embedded in Poly (o-aminophenol) Matrices
Authors: Sonika  , Verma Sushil Kumar , Saha J. , Alsharabi Rim M. , Rajput Shailendra
Published: September 2022

This paper describes a one-step chemically produced multiwalled carbon nanotubes/poly-ortho-aminophenol (MWCNTs/PoAP) nanocomposite film production process using in-situ oxidative polymerization. The

CoCl

2

-doped nanocomposites exhibit good stability and increased magnetic performance. The morphological analysis revealed that PoAP deposits on the surface of the nanoparticle result in the creation of a fibrous crystal-like structure. The vibrational spectra show that there is a substantial interaction between PoAP and MWCNT/MWCNT[-COOH]. The introduction of nanocrystalline MWCNTS increases PoAP’s UV absorption and causes a blue shift in π-polaron absorption. The magnetic study of Co-doped MWCNTs/PoAP nanocomposites has shown a marked reduction in the hysteresis behavior, indicating significant hole doping associated with the oxygen functional groups on the surface of xidized carbon ’nanotubes. The syntheses of nanocomposites are silent features of the work with implications in crystal engineering and nanocomposite design for various applications.
Spatial Heterogeneity Analysis of Resource Allocation Efficiency of Sports Venues in China from the Perspective of Polarization Theory
Authors: Cao Jian , Geng Jie , Shen Weimin
Published: September 2022

There are not many analyses of the degree of variation in the efficiency of the allocation of sports venues in China. The results show that the allocation efficiency of sports venues in China is very high. The results show that the efficiency of the allocation of sports venues in China generally shows a fluctuating upward trend, with the average efficiency value increasing from 0.7 in 2013 to 0.9 in 2014, and there are significant differences at the three regional levels of East, Central, and West China and at the level of each province and autonomous region. The efficiency of the allocation of sports venue resources in the three regions shows a geographical pattern of “eastern region > western region > central region.” The regional disparity in the efficiency of the allocation of sports venue resources in China gradually increases during the period under study, with the opening and closing values of the kernel density curve for 2013–2017, showing an overall “. The nuclear density curve in 2017 shows an obvious bimodal curve distribution. Compared with other years, it can be clearly seen that there are fewer areas with low values and more areas with high values. The polarization of the efficiency of China's sports venue resource allocation and layout has been revealed, and the core density curve is shown as a whole. It can be seen from the sports venue resource allocation index that during the study year, the changes and fluctuations of each major region were different, and the national Er index showed a trend of “Λ.” The shape of the national Er index is “Λ,” while the eastern, central, and western regions are in the shape of “N,” declining slowly and remaining stable, respectively. The ER index fluctuates the most in the eastern region. Hence, the change in the ER index in eastern China plays a dominant role in the polarization of the overall resource allocation efficiency of sports venues in China.
Mitochondrial Matrix Protease ClpP Agonists Inhibit Cancer Stem Cell Function in Breast Cancer Cells by Disrupting Mitochondrial Homeostasis
Authors: Greer Yoshimi Endo , Hernandez Lidia , Fennell Emily M.J. , Kundu Manjari , Voeller Donna , Chari Raj , Gilbert Samuel F. , Gilbert Thomas S.K. , Ratnayake Shashikala , Tang Binwu , Hafner Markus , Chen Qingrong , Meerzaman Daoud , Iwanowicz Edwin , Annunziata Christina M. , Graves Lee M. , Lipkowitz Stanley
Published: September 2022

Mitochondria are multifaceted organelles which are important for bioenergetics, biosynthesis, and signaling in metazoans. Mitochondrial functions are frequently altered in cancer to promote both the energy and the necessary metabolic intermediates for biosynthesis required for tumor growth. Cancer stem cells (CSC) contribute to chemotherapy resistance, relapse, and metastasis. Recent studies have shown that while non-stem, bulk cancer cells utilize glycolysis, breast CSCs are more dependent on oxidative phosphorylation (OxPhos) and therefore targeting mitochondria may inhibit CSC function. We previously reported that small molecule ONC201, which is an agonist for the mitochondrial caseinolytic protease (ClpP), induces mitochondrial dysfunction in breast cancer cells. In this study, we report that ClpP agonists inhibit breast cancer cell proliferation and CSC function in vitro and in vivo. Mechanistically, we found that OxPhos inhibition downregulates multiple pathways required for CSC function, such as the mevalonate pathway, YAP, Myc, and the HIF pathway. ClpP agonists showed significantly greater inhibitory effect on CSC functions compared with other mitochondria-targeting drugs. Further studies showed that ClpP agonists deplete NAD(P)+ and NAD(P)H, induce redox imbalance, dysregulate one-carbon metabolism and proline biosynthesis. Downregulation of these pathways by ClpP agonists further contribute to the inhibition of CSC function. In conclusion, ClpP agonists inhibit breast CSC functions by disrupting mitochondrial homeostasis in breast cancer cells and inhibiting multiple pathways critical to CSC function.

Significance:

ClpP agonists disrupt mitochondrial homeostasis by activating mitochondrial matrix protease ClpP. We report that ClpP agonists inhibit cell growth and CSC functions in breast cancer models by modulating multiple metabolic pathways essential to CSC function.
Stromal Vascular Fraction Reverses the Age-Related Impairment in Revascularization following Injury
Authors: Rowe Gabrielle , Heng David S. , Beare Jason E. , Hodges Nicholas A. , Tracy Evan P. , Murfee Walter L. , LeBlanc Amanda J.
Published: September 2022

Adipose-derived stromal vascular fraction (SVF) has emerged as a potential regenerative therapy, but few studies utilize SVF in a setting of advanced age. Additionally, the specific cell population in SVF providing therapeutic benefit is unknown. We hypothesized that aging would alter the composition of cell populations present in SVF and its ability to promote angiogenesis following injury, a mechanism that is T cell-mediated. SVF isolated from young and old Fischer 344 rats was examined with flow cytometry for cell composition. Mesenteric windows from old rats were isolated following exteriorization-induced (EI) hypoxic injury and intravenous injection of one of four cell therapies: (1) SVF from young or (2) old donors, (3) SVF from old donors depleted of or (4) enriched for T cells. Advancing age increased the SVF T-cell population but reduced revascularization following injury. Both young and aged SVF incorporated throughout the host mesenteric microvessels, but only young SVF significantly increased vascular area following EI. This study highlights the effect of donor age on SVF angiogenic efficacy and demonstrates how the ex vivo mesenteric-window model can be used in conjunction with SVF therapy to investigate its contribution to angiogenesis.
Effect of Hemadsorption Therapy in Critically Ill Patients with COVID-19 (CYTOCOV-19): A Prospective Randomized Controlled Pilot Trial
Authors: Jarczak Dominik , Roedl Kevin , Fischer Marlene , de Heer Geraldine , Burdelski Christoph , Frings Daniel Peter , Sensen Barbara , Boenisch Olaf , Tariparast Pischtaz Adel , Kluge Stefan , Nierhaus Axel
Published: September 2022

Introduction: Immunomodulatory therapies have shown beneficial effects in patients with severe COVID-19. Patients with hypercytokinemia might benefit from the removal of inflammatory mediators via hemadsorption. Methods: Single-center prospective randomized trial at the University Medical Center Hamburg-Eppendorf (Germany). Patients with confirmed COVID-19, refractory shock (norepinephrine ≥0.2 µg/kg/min to maintain a mean arterial pressure ≥65 mm Hg), interleukin-6 (IL-6) ≥500 ng/L, and an indication for renal replacement therapy or extracorporeal membrane oxygenation were included. Patients received either hemadsorption therapy (HT) or standard medical therapy (SMT). For HT, a CytoSorb® adsorber was used for up to 5 days and was replaced every 18–24 h. The primary endpoint was sustained hemodynamic improvement (norepinephrine ≤0.05 µg/kg/min ≥24 h). Results: Of 242 screened patients, 24 were randomized and assigned to either HT (N = 12) or SMT (N = 12). Both groups had similar severity as assessed by SAPS II (median 75 points HT group vs. 79 SMT group, p = 0.590) and SOFA (17 vs. 16, p = 0.551). Median IL-6 levels were 2,269 (IQR 948–3,679) and 3,747 (1,301–5,415) ng/L in the HT and SMT groups at baseline, respectively (p = 0.378). Shock resolution (primary endpoint) was reached in 33% (4/12) versus 17% (2/12) in the HT and SMT groups, respectively (p = 0.640). Twenty-eight-day mortality was 58% (7/12) in the HT compared to 67% (8/12) in the SMT group (p = 1.0). During the treatment period of 5 days, 6/12 (50%) of the SMT patients died, in contrast to 1/12 (8%) in the HT group. Conclusion: HT was associated with a non-significant trend toward clinical improvement within the intervention period. In selected patients, HT might be an option for stabilization before transfer and further therapeutic decisions. This finding warrants further investigation in larger trials.
A Decade On: The Evolving Renaissance in Intracranial Atherosclerotic Disease
Authors: Beaman Charles , Yaghi Shadi , Liebeskind David S.
Published: September 2022

Intracranial atherosclerotic disease is the most common cause of stroke worldwide. The past decade of research in intracranial atherosclerotic disease has led to marginally improved medical therapy, yet recurrent stroke rates remain high. Despite the enormous global burden of disease, we lack effective clinical acumen to appropriately risk stratify patients and optimize the therapeutic approach. In this review, we examine our current understanding of intracranial atherosclerotic disease pathophysiology, imaging techniques, lifestyle, medical therapy, and endovascular strategies. We also present steps needed to incorporate imaging and serum biomarkers in intracranial atherosclerotic disease to facilitate individualized treatment plans and realize the potential of precision medicine in this global health disorder. Trials in the next decade should be targeted to help us gain a better understanding of key mechanisms and disease course with an ultimate goal of improving long‐term patient outcomes.
Extreme Measures: A National Descriptive Analysis of Closure and Restructuring of Traditional Public, Charter, and Private Schools
Authors: Harris Douglas N. , Martinez-Pabon Valentina
Published: September 2022

We describe the levels, trends, and patterns of school closure and restructuring in the United States from 1991 to 2019 across all sectors using a near census of K–12 schools. Focusing on the years with the best available data, 2014–18, we find that the annual closure rate of charter, private, and traditional public schools (TPSs) were 5.1, 2.9, and 0.9 percent, respectively. The annual restructuring rates are 2.0 percent for charter schools and 0.6 percent for TPSs. Regression analysis shows that these differences in closure and restructuring rates by sector drop slightly after controlling for student and school characteristics. The strongest predictor of increased closures is low student enrollment, especially in private schools. In charter and traditional public schools, achievement measures predict closure and restructuring nearly as strongly as enrollment. While racial and income composition are weaker predictors of closure/restructuring, that they predict at all, after controlling for many other factors, raises some equity concerns. We also discuss ways in which the forces behind closure/restructuring may be difficult to uncover with this type of quantitative analysis.
Beyond Painting
Authors: Krauss Rosalind E.
Published: September 2022

Rosalind Krauss argues that the 2020 Donald Judd retrospective at the Museum of Modern Art shows that the painterly side of this famously “anti-painter” artist was more pronounced than he would have ever admitted.
Getting on Top of a Demon (Luke 4:39)
Authors: Duncan J. , Derrett M.
Published: September 2022

At Luke 4:38-39 Jesus anomalously stands above the patient. Jewish impurity moved vertically upwards and downwards, and here a source of purity and sanctification (cf. Mt. 23:18-19) defeats a demon, a source of impurity, by exorcism. Jesus mimes the common and biblical power-relation between ‛up’ and ‛down’ (Dt. 28:13). Standing epanō (Heb. lema ‛alah) he threatens (2 Sa. 1:9) the demon, not the woman. ‛Down’ and ‛underneath’ is where Satan and his associates belong (Lk. 10:17-20). One may direct power downwards by overshadowing, not only detrimentally but also beneficially (cf. 1 Ki. 17:21; et. al.), as another woman knew (Lk. 8:44). Luke assumes popular Jewish notions in this area.
Justification and Justice: An Edwardsean Proposal
Authors: Otto Randall E.
Published: September 2022

The historically debated relationship between justification and works has been reopened with the liberationist emphasis on the centrality of justice to justification. In his own doctrine of justification, the great eighteenth-century American theologian Jonathan Edwards provided a means toward the resolution of this debate in teaching that both faith and evangelical obedience (e.g., works of justice) are necessary conditions of justification. Edwards properly maintained that justification is a gracious and sovereign declaration of God that man is righteous acceptilatio, while also affirming that justification is contingent upon a state of holiness and the performance of justice, thus balancing the competing concerns evidenced in the historical debate and showing us a way toward promoting unity on this critical doctrine.
New Life Amid the Alien Corn: The Book of Ruth
Authors: Thompson Michael E. W.
Published: September 2022

Neither seeking to resolve legal details nor undertaking character studies is likely to aid our understanding of the book of Ruth. Rather, the work is a ‛story’ which begins with multiple problems in Moab and ends with abundance in Judah. The book thus deals with the theme of providence which is effected by the actions ofboth Yahweh and various humans, especially Ruth and Boaz. The intertwining of divine and human activity is emphasized in particular through the prayers of intercession and thanksgiving. These prayers are given particular attention in this article.
Conversion in the Bible
Authors: France R. T.
Published: September 2022

A variety of Hebrew and Greek words are used in the Bible to convey the concept of ‛conversion’. The New Testament recognises both ‛insider conversion’ and ‛outsider conversion’—the former being a call to return to their God and the latter demanding both a new experience of God and a change of religious affiliation. The distinction rests on where a person comes from and the degree of dislocation involved in joining the community of faith. Nevertheless, within the new community the distinction is theologically unimportant. As the church became increasingly separate from Judaism, the conversion of Jews was seen more and more as ‛outsider conversion’; with the growth of ‛nominal Christianity’ the need for ‛insider conversion’ has redeveloped.
The Hypostatic Union: How Did Jesus Function?
Authors: Helland Roger
Published: September 2022

Orthodox Christology has affirmed ontologically the full humanity and full deity in the one Person Jesus. The problem of how these two natures could practically function still exists. The New Testament—predominantly the Synoptics—reveals a Jesus who experienced limitations and finiteness. He, furthermore, did not perform supernatural works out of his inherent deity but by dependence on the Father and empowered by the Holy Spirit. However, he did not divest his deity or his attributes of deity but curtailed their exercise. Jesus was unique as the Son of God and a prophet who enjoyed an intimacy and special status with the Father. Therefore, Jesus is a realistic model for his disciples on how to live in dependence on the Father and empowered by the Holy Spirit to proclaim the Kingdom of God and minister in the supernatural as he did.
The Significance of Elijah in James 5:13-18
Authors: Warrington Keith
Published: September 2022

The fact that the illustration from the life of Elijah has been inserted at the end of the letter of James may suggest that it has limited significance to the pericope in which it is included. However, it is to be noted that resident within the story are a number of important characteristics that confirm and clarify his practical advice concerning ministry to those in the local fellowship who are suffering from an unidentified weakness. Thus, to his mainly Jewish Christian readers, he provides the example of a well known figure from the Old Testament whom they are to emulate in their service to the suffering.
Praying Together: A Note on Philemon 22
Authors: Haykin Michael A. G.
Published: September 2022

The significance of the shift to the second person plural in Philemon 22 has often been ignored. The entire house church should, it is assumed, be engaged in prayer for Paul and not just Philemon himself.
Bishop or Presbyter? French Reformed Ecclesiology in 1559
Authors: Clifford Alan C.
Published: September 2022

Unlike semi-reformed Anglicanism’s retention of episcopacy, the French Reformed Church swiftly adopted presbyterian order in 1559. While the Anglican settlement held an attraction for some pastors of the Eglise Réformée, their appeal to Calvin’s authority had little justification. Recognising the thrust of Calvin’s biblical insights, the first French National Synod saw the significance of a fully reformed ecclesiology for a consistent expression of evangelical soteriology. In rejecting episcopacy, they rejected the concept of a sacrificing priest in favour of a preaching pastor. Thus the Anglican via media possessed potential for ensuring that recent debates over the ordination of women would hinge on medieval theories of priesthood rather than a fully reformed concept of ministerial order.
Taxonomic treatment of the genus Campanulorchis (Orchidaceae)
Authors: VO DOAN TRUNG , AVERYANOV LEONID , MAISAK TATIANA , CANH NGUYEN VAN , NGUYEN HUU CUONG , DANG MINH QUAN , DANG VAN SON , TRUONG QUANG TAM , VUONG TRUONG BA
Published: September 2022

The taxonomic treatment of the genus Campanulorchis is herein presented. Short description, data on habitat, phenology, distribution, illustrations and identification key for all species are included. Campanulorchis globifera was firstly recorded for the orchid flora of Cambodia and C. thao firstly recorded in Laos.
Two new species and two new records of Onychiurinae (Collembola, Onychiuridae) from the Nilgiris, India
Authors: THUNNISA ABU MUHSINA , ARBEA JAVIER IGNACIO , SUMITHRA NALLATHAMBI , MANDAL GURU PADA , SANIL RAVEENDRANATHANPILLAI
Published: September 2022

Four species of Onychiurinae are reported from the Nilgiris, Western Ghats, southern India, including two new species, Thalassaphorura udagaiensis sp. nov. and Protaphorura sholai sp. nov., and two new records for India: Protaphorura fimata (Gisin, 1952) and Orthonychiurus folsomi (Schäffer, 1900). Thalassaphorura udagaiensis sp. nov. can be separated easily from the similar species T. encarpata by the presence of 10/011/221110 dorsal S-chaetae and shorter anal spines. Protaphorura sholai sp. nov. is the most similar to the species P. microtica, P. subarctica and P. levantina as having the same number of ventral pseudocelli and parapseudocelli on abdomen; it can be easily distinguished by the position of head chaeta p2 in relation to p1 and p3, shorter M and Sp chaetae on Abd V and longer anal spines. We also sequenced the mitochondrial barcode region of cytochrome oxidase I (658 base pairs) to confirm the species status.
Life History of Erotylina jaspidea (Erichson, 1847) (Coleoptera, Erotyloidea, Erotylidae, Erotylini)
Authors: XAVIER MIGUEL DORCINO , PECCI-MADDALENA ITALO SALVATORE DE CASTRO , LOPES-ANDRADE CRISTIANO , BASEIA IURI GOULART
Published: September 2022

The life history of Erotylina jaspidea (Erichson, 1847) (Coleoptera, Erotyloidea, Erotylidae, Erotylini) is described. A female specimen was found in an Atlantic Forest remnant in Northeast Brazil. After oviposition, individuals were reared in Petri dish and terrarium, feeding on basidiomes of Lentinus substrictus (Bolton) Zmitr. & Kovalenko, Favolus tenuiculus P. Beauv (Polyporaceae) and an unidentified resupinate fungus. Growth and feeding behaviors were regularly observed. We provide information on the observed life history stages, together with morphological descriptions, and photographs of eggs, larvae, pupae and adults. We compared our description of the teneral E. jaspidea to species of similar color pattern. Furthermore, we discuss hypotheses about larval defensive behavior and total instar durations in E. jaspidea and other Erotylinae representatives. The present work is the first to provide a description for the life history of a species of the genus Erotylina.
Rediscovery of the endangered Amphilophus lyonsi (Gosse 1966) (Cichliformes: Cichlidae) in Costa Rica; extended diagnosis and description and new ecological data
Authors: ANGULO ARTURO , GIL-LEÓN JORGE SAN , OVIEDO-SOTO ALEJANDRO , ABARCA-ODIO JUAN I. , UMAÑA-VILLALOBOS GERARDO
Published: September 2022

In this paper we report the rediscovery of the endangered cichlid fish Amphilophus lyonsi (Gosse 1966) in the southern Pacific region of Costa Rica. Additionally, we provide new and updated information on the morphology, growth, habitat use and distribution of the species based on data and specimens recently collected as well as on museum material. This information will be relevant for future taxonomic and conservation studies/purposes, contributing to a better understanding on the biology of the species.
The Utility of ProbSevere v2.0 for Predicting Pulse Severe Thunderstorms
Authors: Gard Thomas L. , Fuelberg Henry E. , Cintineo John L.
Published: September 2022

Pulse severe storms are single-cell thunderstorms that produce severe wind and/or severe hail for a brief period of time. These storms pose a major warm season forecasting problem since forecasters presently do not have sufficient guidance to know which, if any, of the cells that are observed will become severe. The empirical Probability of Severe (ProbSevere) model, developed by the Cooperative Institute for Meteorological Satellite Studies (CIMSS), fuses real-time data to produce short-term (0–60 min), statistically derived probabilistic forecasts of thunderstorm intensity. This study evaluates the ability of ProbSevere to predict pulse severe storms in the southeast United States. ProbSevere objects fitting the usual definition of a pulse severe environment were matched with severe events from Storm Data to create a dataset of ProbSevere objects that corresponded to pulse severe thunderstorms. A null dataset consisted of objects in pulse severe environments that did not match with a severe event. Results reveal that ProbSevere’s probabilities are small to moderate at the times corresponding to pulse severe events. While probabilities of nonsevere storms are generally smaller, there are a large number of outliers. Lightning flash rate is the only predictor relevant to this study that correlates strongly with increasingly favorable pulse storm probabilities. We conclude that ProbSevere provides forecasters only limited guidance as to whether a pulse severe event will soon occur. Developing a version of ProbSevere specifically for pulse severe storms would likely lead to better predictability for this mode of convection.
Datanalysing the uninsured: The coloniality of inclusive insurance platforms
Authors: Perticone Yannick , Graz Jean-Christophe , Rahel Kunz
Published: September 2022

This article explores the rise of digital platforms for insurance coverage related to the financial inclusion agenda in developing and emerging economies. The current literature focuses mostly on the emergence and implications of Superplatforms based in core capitalist economies. Combining insights from studies on platform capitalism with post/decolonial scholarship in international political economy, we argue that the rise of inclusive insurance supported by platforms relies on three dimensions of what we term datanalysing: (a) an interoperable and safe digital infrastructure legitimized by international standards; (b) the collection of racially hierarchized data; and (c) the appropriation of data by objectifying the targeted individuals. As datanalysing turns populations from the Global South into profitable resources from which extracting financial value, it sustains colonial practices censing and classifying subjugated populations. We illustrate our argument with the case of motor insurance coverage. Our analysis offers a wider empirical understanding of the global expansion of platform capitalism to previously unmarketable populations. We suggest that research should place greater emphasis on socio-historical dimensions to highlight the inconsistent and exploitative character of the inclusive insurance agenda.
Choroidal structural features of acquired vitelliform lesions in non-exudative age-related macular degeneration
Authors: Demirel Sibel , Yanık Özge , Özcan Gökçen , Batıoğlu Figen , Özmert Emin
Published: September 2022

Purpose

To define the choroidal morphological characteristics of non-exudative age-related macular degeneration (AMD) cases associated with acquired vitelliform lesions (AVLs).

Methods

This retrospective study included intermediate AMD patients with AVLs (Group1, 21eyes) and without AVLs (Group2, 21eyes). A healthy control group was (Group3, 23eyes) also included. Subfoveal choroidal thickness (SFCT), greatest basal diameter (GBD), and maximum height (MH) of the largest PED were measured on spectral domain optical coherence tomography. Internal reflectivity of PEDs and total choroidal area (TCA) were measured using ImageJ software. The TCA was binarized to the luminal area (LA) and stromal area. The choroidal vascularity index (CVI) was assessed.

Results

The mean SFCT, TCA, and LA were higher in Group 1 (290.3 ± 86.8 μm, 0.840 ± 0.302 mm2, 0.602 ± 0.227 mm2) than in Group 2 (215.6 ± 85.0 μm, 0.594 ± 0.183 mm2, 0.429 ± 0.139 mm2) ( p = 0.014, p = 0.017, p = 0.020, respectively). There was no significant difference in the CVI measurements between Group 1 and Group 2 (p = 1.000). The mean GBD and MH of the PED was higher in Group 1 (1443 ± 595 µm, 188 ± 86 µm) than in Group 2 (851 ± 368 µm, 119 ± 38 µm) ( p = <0.001, p = 0.001, respectively). Internal PED reflectivity was significantly lower in Group 1 (0.44 ± 0.21) than in Group 2 (0.66 ± 0.17) ( p = <0.001). Internal PED reflectivity showed negative correlation with GBD and MH of the PED in Group 1 (r = −0.587, p = 0.005; rho = −0.448, p = 0.042, respectively). In Group 2, internal PED reflectivity had a negative correlation with MH of the PED (rho = −0.511, p = 0.018).

Conclusion

Non-exudative AMD patients with AVLs are more prone to have a thick choroid and large hyporeflective PEDs as compared to the those without AVLs.
A comparative cohort study of gastrointestinal oncology patients: Impact of a shift to telehealth on delivery of interprofessional cancer care
Authors: Hansen Madison , Schiele Kristan , Schear Rebekkah M , Richardson Robin N , Munoz Rebecca J , Bourne Garrett , Eckhardt S Gail , Kvale Elizabeth
Published: September 2022

Early studies of oncology visits performed via telehealth demonstrate patient and provider satisfaction; however, understanding of the impact of telehealth on clinic workflows is limited. The incorporation of telehealth visits into an interprofessional model of oncology care was evaluated to assess for changes in care delivery and patient engagement. New patients with a gastrointestinal cancer diagnosis who were actively undergoing treatment and followed for at least three months were divided into two cohorts based on telehealth utilization. Individual patient charts were reviewed by touchpoint, consisting of in-person visits, telehealth visits, phone calls, and patient portal messages. A total of 28 patient charts were analyzed, 11 pre-telehealth conventional care patients, and 17 telehealth patients. Telehealth cohort patients demonstrated an increased average number of total touchpoints when compared to the pre-telehealth cohort ( p-value = 0.008) and had an increased number of patient portal and phone call touchpoints ( p-value = 0.00 and  0.002). Telehealth provided more interactions between patients and providers demonstrating increased connectivity between a patient and their care team throughout their complex cancer journey. Clinic workflows may need to adjust to account for the increased demand of unscheduled patient interactions.
Additional evidence that valence does not affect serial recall
Authors: Guitard Dominic , Neath Ian , Saint-Aubin Jean
Published: September 2022

In immediate serial recall, a canonical short-term memory task, it is well established that performance is affected by several sublexical, lexical, and semantic factors. One factor that receives a growing interest is valence, whether a word is categorised as positive (e.g., happy) or as negative (e.g., pain). However, contradictory findings have recently emerged. Tse and Altarriba in two experiments with one set of stimuli and fixed lists concluded that valence affects serial recall performance, while Bireta et al. in three experiments with three sets of stimuli and randomised lists concluded that valence does not affect serial recall performance. Two experiments assessed the experimental discrepancy between Tse and Altarriba and Bireta et al. For both experiments, in one block, every participant saw the exact same lists as those used in Tse and Altarriba, and in the other block, each list was randomly constructed for each participant, as was done in Bireta et al. In Experiment 1, with concrete words varying in valence, we replicated the results of Tse and Altarriba with fixed lists and the results of Bireta et al. with randomised lists. In Experiment 2, with abstract words with both fixed and randomised lists, we replicate the absence of effect valence like Tse and Altarriba and Bireta et al. Overall, we conclude that valence does not affect serial recall and the discrepancy was attributed to the peculiarity of the fixed lists used by Tse and Altarriba.
Gesture use in L1-Turkish and L2-English: Evidence from emotional narrative retellings
Authors: Emir Özder Levent , Özer Demet , Göksun Tilbe
Published: September 2022

Bilinguals tend to produce more co-speech hand gestures to compensate for reduced communicative proficiency when speaking in their L2. We here investigated L1-Turkish and L2-English speakers’ gesture use in an emotional context. We specifically asked whether and how (1) speakers gestured differently while retelling L1 versus L2 and positive versus negative narratives and (2) gesture production during retellings was associated with speakers’ later subjective emotional intensity ratings of those narratives. We asked 22 participants to read and then retell eight emotion-laden narratives (half positive, half negative; half Turkish, half English). We analysed gesture frequency during the entire retelling and during emotional speech only (i.e., gestures that co-occur with emotional phrases such as “happy”). Our results showed that participants produced more representational gestures in L2 than in L1; however, they used more representational gestures during emotional content in L1 than in L2. Participants also produced more co-emotional speech gestures when retelling negative than positive narratives, regardless of language, and more beat gestures co-occurring with emotional speech in negative narratives in L1. Furthermore, using more gestures when retelling a narrative was associated with increased emotional intensity ratings for narratives. Overall, these findings suggest that (1) bilinguals might use representational gestures to compensate for reduced linguistic proficiency in their L2, (2) speakers use more gestures to express negative emotional information, particularly during emotional speech, and (3) gesture production may enhance the encoding of emotional information, which subsequently leads to the intensification of emotion perception.
El sentido de coherencia y las habilidades para la vida como factores protectores en personas con prediabetes
Authors: Noguera-Suquet Judit , Reig-Garcia Glòria , Homs-Romero Erica , Gelabert-Vilella Sandra , Roura-Poch Pere , Malagón-Aguilera María del Carmen
Published: September 2022

Objetivo:

analizar el sentido de coherencia y las habilidades para la vida y su relación con el cumplimiento del estilo de vida saludable.

Método:

estudio observacional transversal en personas con prediabetes atendidas en atención primaria, quienes respondieron a un cuestionario con variables sociodemográficas y hábitos saludables y a los cuestionarios de sentido de coherencia y habilidades para la vida. Se realizó un análisis descriptivo, bivariante y un modelo de regresión múltiple.

Resultados:

los y las participantes con mayor sentido de coherencia son quienes presentan mayores habilidades para la vida (Pearson = 0.470; p ⩽ 0.001) y mantienen un estilo de vida más saludable (B:1.24; p = 0.001). Una mayor puntuación de las habilidades de la vida se relaciona con un estilo de vida saludable (Pearson = 0.355, p < 0.001). El sentido de coherencia predice el estilo de vida saludable (BB = 0.21, p = 0.001).

Conclusión:

las personas con prediabetes con un mayor sentido de coherencia y más habilidades para la vida realizan conductas más saludables con relación a la dieta, al ejercicio físico y al hábito tabáquico. Las personas con mayor sentido de coherencia tienen mayor probabilidad de seguir el estilo de vida saludable.
Minimalist Storytelling: The Natural Framing of Electoral Violence by Mexican Media
Authors: Schedler Andreas
Published: September 2022

During the first two decades of the twenty-first century, Mexico’s so-called drug war claimed around a quarter of a million lives. Adapting to this enduring epidemic of violence, the print media have adopted a minimalist reporting style that gives only thin, formulaic accounts of violent events. As I argue, established journalistic minimalism does more than provide little information about violence. With practised impassiveness, it frames violence in a way that creates a certain narrative: not of social actors to be understood but of natural events to be endured. Through a qualitative content analysis of over 1200 news reports, I examine the persistent force of this “natural” frame in the face of an extraordinary development: the unprecedented intrusion of political violence into the 2018 general elections, when forty-eight candidates were assassinated.
Prevalence of Neck Pain in Patients with Degenerative Cervical Myelopathy and Short-Term Response After Operative Treatment: A Cohort Study of 664 Patients From 26 Global Sites
Authors: Schneider Michel M. , Badhiwala Jetan H. , Alvi Mohammed Ali , Tetreault Lindsay A. , Kalsi Pratipal , Idler Randy K. , Wilson Jefferson R. , Fehlings Michael G.
Published: September 2022

Study Design

Ambispective cohort study.

Objectives

1) To define the prevalence of neck pain in patients with degenerative cervical myelopathy (DCM). 2) To identify associated factors of preoperative neck pain in patients with DCM. 3) To assess the neck pain response to surgical intervention.

Methods

757 patients with DCM were enrolled at 26 global sites from 2005 to 2011. A total of 664 patients had complete neck pain scores preoperatively (Neck Disability Index, NDI). The prevalence and severity of neck pain preoperatively and at the 6-months follow-up was summarized. Functional assessments of individuals with and without pain were compared. Associations of preoperative neck pain and related factors were evaluated.

Results

Preoperatively, 79.2% of patients reported neck pain while 20.8% had no neck pain. Of individuals with neck pain, 20.2% rated their pain as very mild, 27.9% as moderate, 19.6% as fairly severe, 9.6% as very severe and 1.9% as the worst imaginable. Functional status (mJOA), number of stenotic levels, age, and duration of symptoms did not significantly differ in patients with and without pain. Factors associated with the presence of neck pain were female gender, BMI ≥27 kg/m2, rheumatologic and gastrointestinal comorbidities, and age <57 years. Neck pain improved significantly from the preoperative examination to the 6-months postoperative follow-up ( P < .0001).

Conclusion

Here, we demonstrate a high prevalence of neck pain in patients with DCM as well as a link between gender, body weight, comorbidity and age. We highlight a significant reduction in neck pain 6 months after surgery.
Aggressive Central Giant Cell Granuloma of the Jaw and Adjuvant Denosumab Therapy: Decreased Morbidity and Preserved Function in a 3 Patient Case Series
Authors: Rogol Elizaveta V. , Jun Scott , Broehm Cory J. , Belmonte Jessica
Published: September 2022

We show the benefits of denosumab as adjuvant treatment of gnathic central giant cell granulomas (CGCGs) in 3 female patients, ages 18 to 65. This case series contributes to the growing experience in the medical therapy of these aggressive lesions, and demonstrates denosumab’s potential to decrease surgical morbidity. Central giant cell lesions of the jaw can be locally aggressive and thereby result in severe tissue destruction. Several medications have been evaluated as adjuvant therapy for CGCGs, with investigation of denosumab being the most recent. Our goal was to definitively treat patients with large CGCGs while minimizing unnecessary tissue and function loss. All 3 patients were offered adjuvant therapy with denosumab, since surgical resection alone would have resulted in large segmental defects requiring jaw reconstruction with free tissue transfer. Treatment instead consisted of lesion curettage and adjuvant denosumab therapy. The denosumab treatment protocol we used was based on what is currently recommended for unresectable giant cell tumors of bone (GCTB). Patients have been monitored for 40 months with clinical and radiographic exams, and 2 of them have also had histological evaluation following initiation of denosumab treatment. The 3 patients improved subjectively after the first few denosumab injections and had objective clinical and radiographic improvement after less than 6 months of therapy. Medication treatment length ranged from 10 to 15 months. Radiographic exams showed cortical thickening, resolution of cortical perforations, and calcification within a previously radiolucent region. Our findings are consistent with previous reports, and further support for the use of denosumab in locally aggressive central giant cell lesions. Our patients have thus far avoided large segmental resections, temporomandibular joint disarticulation, and sensory loss which would have resulted from surgical treatment alone. These 3 cases show that denosumab can be effective as adjuvant therapy in the treatment of aggressive gnathic CGCGs.
Oldsite, K2Fe2+[(UO2)(SO4)2]2(H2O)8, a new uranyl sulfate mineral from Utah, USA: its description and implications for the formation and occurrences of uranyl sulfate minerals
Authors: Plášil Jakub , Kampf Anthony R. , Ma Chi , Desor Joy
Published: September 2022

Oldsite (IMA2021-075), ideally K2Fe2+[(UO2)(SO4)2]2(H2O)8, is a new uranyl sulfate mineral found on specimens from the North Mesa Mine group, Temple Mountain, San Rafael district, Emery County, Utah, USA. It is a secondary mineral occurring with alum-(K), halotrichite, metavoltine, quartz, römerite, stanleyite, sulphur, szomolnokite and mathesiusite. It forms rectangular blades flattened on {010} and elongated on [001], reaching ~0.3 mm in length. Crystals are yellow in colour, transparent with a vitreous lustre; the streak is very pale yellow. The mineral is non-fluorescent. Cleavage is excellent on {100} and perfect on {010}; the Mohs hardness is ~2. Crystals are brittle with irregular, splintery fracture. The density measured by flotation in a mixture of methylene iodide and toluene is 3.31 g⋅cm–3; the calculated density is 3.298 g⋅cm–3 for the empirical formula and 3.330 g⋅cm–3 for the ideal formula. Oldsite is biaxial (+), with α = 1.552(2), β = 1.556(2) and γ = 1.588(2) (measured in white light). The 2V measured directly on a spindle stage is 37(1)°; the calculated 2V is 39.6°. Dispersion is r < v, moderate. The optical orientation is X = b, Y = a and Z = c. The mineral is non-pleochroic. The empirical formula of oldsite (on the basis of 28 O apfu) is K1.93(Fe2+0.53Zn0.31V3+0.09Mg0.08)Σ1.02[(U0.98O2)(S1.01O4)2]2(H2O)8. The Raman spectrum is dominated by the vibrations of SO42– and UO22+ units. Oldsite is orthorhombic, Pmn21, a = 12.893(3), b = 8.276(2), c = 11.239(2) Å, V = 1199.2(5) Å3 and Z = 2. The five strongest powder X-ray diffraction lines are [dobs, Å (I, %) (hkl) ]: 8.29 (59) (010), 6.47 (82) (200), 5.10 (62) (210), 4.65 (100) (012, 211) and 3.332 (55) (022, 221). The crystal structure of oldsite was refined from single-crystal X-ray data to R = 0.0258 for 2676 independent observed reflections, with Iobs > 3σ(I). Oldsite is an Fe2+ analogue of svornostite; its crystal structure is based upon infinite chains of uranyl-sulfate polyhedra, which comprises pentagonal UO7 bipyramids sharing four of their equatorial vertices with sulfate tetrahedra such that each tetrahedron is linked to two uranyl bipyramids to form an infinite chain (the free, non-linking equatorial vertex of the uranyl bipyramid is an H2O group). The broader discussion on the origin and composition of uranyl sulfate minerals is made. The new mineral name honours American mineralogist, Dr. Travis A. Olds for his contribution to uranium mineralogy.