bluuebunny/crossref_metadata_2025 huggingface dataset:
Asbestos Exposure and Malignant Mesothelioma in Construction Workers—Epidemiological Remarks by the Italian National Mesothelioma Registry (ReNaM)
Authors: Binazzi Alessandra , Di Marzio Davide , Verardo Marina , Migliore Enrica , Benfatto Lucia , Malacarne Davide , Mensi Carolina , Consonni Dario , Eccher Silvia , Mazzoleni Guido , Comiati Vera , Negro Corrado , Romanelli Antonio , Chellini Elisabetta , Angelini Alessia , Grappasonni Iolanda , Madeo Gabriella , Romeo Elisa , Di Giammarco Annamaria , Carrozza Francesco , Angelillo Italo F. , Cavone Domenica , Vimercati Luigi , Labianca Michele , Tallarigo Federico , Tumino Rosario , Melis Massimo , Bonafede Michela , Scarselli Alberto , Marinaccio Alessandro ,   on behalf of the ReNaM Working Group
Published: December 2021

Notwithstanding the ban in 1992, asbestos exposure for workers in the construction sector in Italy remains a concern. The purpose of this study is to describe the characteristics of malignant mesothelioma (MM) cases recorded by the Italian registry (ReNaM) among construction workers. Incident mesothelioma cases with a definite asbestos exposure have been analyzed. Characteristics of cases and territorial clusters of crude rates of MM in construction workers have been described, as well as the relation between asbestos use before the ban and the historical trend of workforce in the construction sector in Italy. ReNaM has collected 31,572 incident MM cases in the period from 1993 to 2018 and asbestos exposure has been assessed for 24,864 (78.2%) cases. An occupational exposure has been reported for 17,191 MM cases (69.1% of subjects with a definite asbestos exposure). Among them, 3574 had worked in the construction sector, with an increasing trend from 15.8% in the 1993–98 period to 23.9% in 2014–2018 and a ubiquitous territorial distribution. The large use of asbestos in construction sector before the ban makes probability of exposure for workers a real concern still today, particularly for those working in maintenance and removal of old buildings. There is a clear need to assess, inform, and prevent asbestos exposure in this sector.
Factors Associated with Having Family/Whānau or Close Friends Who Used Alcohol or Other Drugs in Harmful Ways among University Students in New Zealand
Authors: Wamamili Ben , Stewart Pauline , Wallace-Bell Mark
Published: December 2021

The consequences of alcohol and other drug (AoD) use are well documented. This study investigated factors associated with having family/whānau or close friend who used AoD in harmful ways in New Zealand. Data came from a July–August 2020 cross-sectional survey of students from eight universities (n = 946). Participants were asked if they had family/whānau or close friends in New Zealand who consumed alcohol or used other drugs (cannabis, ecstasy/MDMA, methamphetamine, cocaine, heroin, prescription drugs, inhalants, or other) in a way that negatively impacted them, their family, or close friends in the last 12 months. Logistic regression assessed associations of having family/whānau or close friend who used AoD harmfully with student characteristics. Of respondents, 36.2% (33.1–39.4) had family/whānau or close friend who had consumed alcohol harmfully, and 42.9% (39.5–46.3) had family/whānau or close friend who had used at least one drug harmfully. Respondents’ age and ethnicity were significantly associated with having family/whānau or close friend who used AoD harmfully. The results suggest widespread harmful AoD use and potentially significant second-hand effects of AoD use in New Zealand. These data can be used to supplement information from traditional in-person surveys of individuals using alcohol and other drug (e.g., the New Zealand Health Survey).
Amid the COVID-19 Pandemic, Unethical Behavior in the Name of the Company: The Role of Job Insecurity, Job Embeddedness, and Turnover Intention
Authors: Elshaer Ibrahim A. , Azazz Alaa M. S.
Published: December 2021

The worldwide economic crisis initiated by the COVID-19 pandemic certainly altered the perception of regular job insecurity dimensions and brought these to the ultimate level. When employees feel insecure, they may decide to participate in unethical behavior in the name of the company to avoid layoff and become retained employees. This study investigated the relationship between job insecurity and unethical organizational behavior through the mediating role of job embeddedness and turnover intention. A total of 685 employees working in five- and four-star hotels and category A travel agents participated in this study. Data were analyzed using structural equation modeling. Job embeddedness and turnover intention were found to be partially mediated by the impact of job insecurity on unethical organizational behavior. Theoretical and practical implications were identified and discussed.
Modulation of Insulin Resistance, Dyslipidemia and Serum Metabolome in iNOS Knockout Mice following Treatment with Nitrite, Metformin, Pioglitazone, and a Combination of Ampicillin and Neomycin
Authors: Aggarwal Hobby , Pathak Priya , Kumar Yashwant , Jagavelu Kumaravelu , Dikshit Madhu
Published: December 2021

Oxidative and nitrosative stress plays a pivotal role in the incidence of metabolic disorders. Studies from this lab and others in iNOS-/- mice have demonstrated occurrence of insulin resistance (IR), hyperglycemia and dyslipidemia highlighting the importance of optimal redox balance. The present study evaluates role of nitrite, L-arginine, antidiabetics (metformin, pioglitazone) and antibiotics (ampicillin-neomycin combination, metronidazole) on metabolic perturbations observed in iNOS-/- mice. The animals were monitored for glucose tolerance (IPGTT), IR (insulin, HOMA-IR, QUICKI), circulating lipids and serum metabolomics (LC-MS). Hyperglycemia, hyperinsulinemia and IR were rescued by nitrite, antidiabetics, and antibiotics treatments in iNOS-/- mice. Glucose intolerance was improved with nitrite, metformin and pioglitazone treatment, while ampicillin-neomycin combination normalised the glucose utilization in iNOS-/- mice. Increased serum phosphatidylethanolamine lipids in iNOS-/- mice were reversed by metformin, pioglitazone and ampicillin-neomycin; dyslipidemia was however marginally improved by nitrite treatment. The metabolic improvements were associated with changes in selected serum metabolites-purines, ceramide, 10-hydroxydecanoate, glucosaminate, diosmetin, sebacic acid, 3-nitrotyrosine and cysteamine. Bacterial metabolites-hippurate, indole-3-ethanol; IR marker-aminoadipate and oxidative stress marker-ophthalmate were reduced by pioglitazone and ampicillin-neomycin, but not by nitrite and metformin treatment. Results obtained in the present study suggest a crucial role of gut microbiota in the metabolic perturbations observed in iNOS-/- mice.
Search for Structural Basis of Interactions of Biogenic Amines with Human TAAR1 and TAAR6 Receptors
Authors: Glyakina Anna V. , Pavlov Constantine D. , Sopova Julia V. , Gainetdinov Raul R. , Leonova Elena I. , Galzitskaya Oxana V.
Published: December 2021

The identification and characterization of ligand-receptor binding sites are important for drug development. Trace amine-associated receptors (TAARs, members of the class A GPCR family) can interact with different biogenic amines and their metabolites, but the structural basis for their recognition by the TAARs is not well understood. In this work, we have revealed for the first time a group of conserved motifs (fingerprints) characterizing TAARs and studied the docking of aromatic (β-phenylethylamine, tyramine) and aliphatic (putrescine and cadaverine) ligands, including gamma-aminobutyric acid, with human TAAR1 and TAAR6 receptors. We have identified orthosteric binding sites for TAAR1 (Asp68, Asp102, Asp284) and TAAR6 (Asp78, Asp112, Asp202). By analyzing the binding results of 7500 structures, we determined that putrescine and cadaverine bind to TAAR1 at one site, Asp68 + Asp102, and to TAAR6 at two sites, Asp78 + Asp112 and Asp112 + Asp202. Tyramine binds to TAAR6 at the same two sites as putrescine and cadaverine and does not bind to TAAR1 at the selected Asp residues. β-Phenylethylamine and gamma-aminobutyric acid do not bind to the TAAR1 and TAAR6 receptors at the selected Asp residues. The search for ligands targeting allosteric and orthosteric sites of TAARs has excellent pharmaceutical potential.
Integration of Genomic Profiling and Organoid Development in Precision Oncology
Authors: Yoon Hyunho , Lee Sanghoon
Published: December 2021

Precision oncology involves an innovative personalized treatment strategy for each cancer patient that provides strategies and options for cancer treatment. Currently, personalized cancer medicine is primarily based on molecular matching. Next-generation sequencing and related technologies, such as single-cell whole-transcriptome sequencing, enable the accurate elucidation of the genetic landscape in individual cancer patients and consequently provide clinical benefits. Furthermore, advances in cancer organoid models that represent genetic variations and mutations in individual cancer patients have direct and important clinical implications in precision oncology. This review aimed to discuss recent advances, clinical potential, and limitations of genomic profiling and the use of organoids in breast and ovarian cancer. We also discuss the integration of genomic profiling and organoid models for applications in cancer precision medicine.
Inducing Energetic Switching Using Klotho Improves Vascular Smooth Muscle Cell Phenotype
Authors: Docherty Craig K. , Strembitska Anastasiya , Baker Christa P. , Schmidt Fiona F. , Reay Kieran , Mercer John R.
Published: December 2021

The cardiovascular disease of atherosclerosis is characterised by aged vascular smooth muscle cells and compromised cell survival. Analysis of human and murine plaques highlights markers of DNA damage such as p53, Ataxia telangiectasia mutated (ATM), and defects in mitochondrial oxidative metabolism as significant observations. The antiageing protein Klotho could prolong VSMC survival in the atherosclerotic plaque and delay the consequences of plaque rupture by improving VSMC phenotype to delay heart attacks and stroke. Comparing wild-type VSMCs from an ApoE model of atherosclerosis with a flox’d Pink1 knockout of inducible mitochondrial dysfunction we show WT Pink1 is essential for normal cell viability, while Klotho mediates energetic switching which may preserve cell survival. Methods: Wild-type ApoE VSMCs were screened to identify potential drug candidates that could improve longevity without inducing cytotoxicity. The central regulator of cell metabolism AMP Kinase was used as a readout of energy homeostasis. Functional energetic switching between oxidative and glycolytic metabolism was assessed using XF24 technology. Live cell imaging was then used as a functional readout for the WT drug response, compared with Pink1 (phosphatase-and-tensin-homolog (PTEN)-induced kinase-1) knockout cells. Results: Candidate drugs were assessed to induce pACC, pAMPK, and pLKB1 before selecting Klotho for its improved ability to perform energetic switching. Klotho mediated an inverse dose-dependent effect and was able to switch between oxidative and glycolytic metabolism. Klotho mediated improved glycolytic energetics in wild-type cells which were not present in Pink1 knockout cells that model mitochondrial dysfunction. Klotho improved WT cell survival and migration, increasing proliferation and decreasing necrosis independent of effects on apoptosis. Conclusions: Klotho plays an important role in VSMC energetics which requires Pink1 to mediate energetic switching between oxidative and glycolytic metabolism. Klotho improved VSMC phenotype and, if targeted to the plaque early in the disease, could be a useful strategy to delay the effects of plaque ageing and improve VSMC survival.
Multiple Immunostainings with Different Epitope Retrievals—The FOLGAS Protocol
Authors: von Schoenfeld Anna , Bronsert Peter , Poc Michael , Fuller Andrew , Filby Andrew , Kraft Stefan , Kurowski Konrad , Sörensen Kristin , Huber Julia , Pfeiffer Jens , Proietti Michele , Stehl Verena , Werner Martin , Seidl Maximilian
Published: December 2021

We describe a sequential multistaining protocol for immunohistochemistry, immunofluorescence and CyTOF imaging for formalin-fixed, paraffin-embedded specimens (FFPE) in the formalin gas-phase (FOLGAS), enabling sequential multistaining, independent from the primary and secondary antibodies and retrieval. Histomorphologic details are preserved, and crossreactivity and loss of signal intensity are not detectable. Combined with a DAB-based hydrophobic masking of metal-labeled primary antibodies, FOLGAS allows the extended use of CyTOF imaging in FFPE sections.
Gas-Transport Characteristics of PdCu–Nb–PdCu Membranes Modified with Nanostructured Palladium Coating
Authors: Petriev Iliya , Pushankina Polina , Shostak Nikita , Baryshev Mikhail
Published: December 2021

A method for obtaining composite gas-diffusion PdCu–Nb–PdCu membranes modified with a nanostructured crystalline coating was developed to increase the performance of Nb-based membranes. A modifying functional layer with a controlled size and composition was synthesized by electrochemical deposition, which made it possible to determine a certain geometric shape for palladium nanocrystallites. Developed PdCu–Nb–PdCu membranes have demonstrated flux values up to 0.232 mmol s−1 m−2 in the processes of diffusion purification of hydrogen at 400 °C. A very significant difference in the hydrogen fluxes through the modified and non-modified composite PdCu–Nb–PdCu membranes reached 1.73 times at the lower threshold temperature of 300 °C. Cu doping of protective layer did not affect the selective properties of the membranes, which was confirmed by the obtained high selectivity values up to 1323, and made it possible to reduce the noble metal content. The research data indicate that the modification of the membrane surface significantly accelerates the hydrogen transfer process at sufficiently low temperatures due to the acceleration of dissociative–associative processes on the surface. The reported approach demonstrates new possibilities for creating productive and cost-efficient membranes based on niobium.
Effect of Cry Toxins on Xylotrechus arvicola (Coleoptera: Cerambycidae) Larvae
Authors: Rodríguez-González Álvaro , Porteous-Álvarez Alejandra J. , Guerra Marcos , González-López Óscar , Casquero Pedro A. , Escriche Baltasar
Published: December 2021

The beetle Xylotrechus arvicola is a destructive pest in vineyards (Vitis vinifera) in the main wine-producing areas of the Iberian Peninsula. X. arvicola larvae bore into the grapevine wood-making galleries, thus damaging the plant both directly and indirectly; the latter through the proliferation of wood fungi, which can invade the inside of the plant, decreasing the quality and quantity of its production. The susceptibility of X. arvicola larvae to five coleopteran toxic Cry proteins (Cry1B, Cry1I, Cry3A, Cry7A, and Cry23/37) was evaluated under laboratory conditions in order to deepen the knowledge of the effect of these proteins on this insect throughout its biological development. Cry7Ab and Cry1Ba were the most effective in controlling X. arvicola larvae due to the significant reduction in larvae survival (32.9 and 25.9 days, respectively), and by causing serious alterations in the larvae during the remaining months of their development. The developmental stage of the prepupal and pupal stages was not affected by the previous ingestion of Cry proteins. The Cry proteins tested could be applied to control X. arvicola larvae since they were able to kill them and cause serious alterations in the larvae during the remaining months of development that followed. The data presented suggest that these Cry proteins can be used as bioinsecticides against the larvae of this insect, applying them only at the moment when the larvae hatch from the egg outside the grapevine wood (this would only be useful and justified if the economic threshold is exceeded) in order to avoid the rapid evolution of resistance against these toxins since not all of the larvae were killed and thus increase vine wood protection.
A MODWT-Based Algorithm for the Identification and Removal of Jumps/Short-Term Distortions in Displacement Measurements Used for Structural Health Monitoring
Authors: Rodrigues Davi V. Q. , Zuo Delong , Li Changzhi
Published: December 2021

Researchers have made substantial efforts to improve the measurement of structural reciprocal motion using radars in the last years. However, the signal-to-noise ratio of the radar’s received signal still plays an important role for long-term monitoring of structures that are susceptible to excessive vibration. Although the prolonged monitoring of structural deflections may provide paramount information for the assessment of structural condition, most of the existing structural health monitoring (SHM) works did not consider the challenges to handle long-term displacement measurements when the signal-to-noise ratio of the measurement is low. This may cause discontinuities in the detected reciprocal motion and can result in wrong assessments during the data analyses. This paper introduces a novel approach that uses a wavelet-based multi-resolution analysis to correct short-term distortions in the calculated displacements even when previously proposed denoising techniques are not effective. Experimental results are presented to validate and demonstrate the feasibility of the proposed algorithm. The advantages and limitations of the proposed approach are also discussed.
Dissecting the Complexity of Early Heart Progenitor Cells
Authors: Sendra Miquel , Domínguez Jorge , Torres Miguel , Ocaña Oscar
Published: December 2021

Early heart development depends on the coordinated participation of heterogeneous cell sources. As pioneer work from Adriana C. Gittenberger-de Groot demonstrated, characterizing these distinct cell sources helps us to understand congenital heart defects. Despite decades of research on the segregation of lineages that form the primitive heart tube, we are far from understanding its full complexity. Currently, single-cell approaches are providing an unprecedented level of detail on cellular heterogeneity, offering new opportunities to decipher its functional role. In this review, we will focus on three key aspects of early heart morphogenesis: First, the segregation of myocardial and endocardial lineages, which yields an early lineage diversification in cardiac development; second, the signaling cues driving differentiation in these progenitor cells; and third, the transcriptional heterogeneity of cardiomyocyte progenitors of the primitive heart tube. Finally, we discuss how single-cell transcriptomics and epigenomics, together with live imaging and functional analyses, will likely transform the way we delve into the complexity of cardiac development and its links with congenital defects.
Epidemiology, Comorbidities, and Prescription Patterns of Korean Prurigo Nodularis Patients: A Multi-Institution Study
Authors: Woo Yu-Ri , Wang Sehee , Sohn Kyung-Ah , Kim Hei-Sung
Published: December 2021

Prurigo nodularis (PN) is a chronic dermatosis typified by extraordinarily itchy nodules. However, little is known of the nature and extent of PN in Asian people. This study aimed to describe the epidemiology, comorbidities, and prescription pattern of PN in Koreans based on a large dermatology outpatient cohort. Patients with PN were identified from the Catholic Medical Center (CMC) clinical data warehouse. Anonymized data on age, sex, diagnostic codes, prescriptions, visitation dates, and other relevant parameters were collected. Pearson correlation analysis was used to calculate the correlation between PN prevalence and patient age. Conditional logistic regression modeling was adopted to measure the comorbidity risk of PN. A total of 3591 patients with PN were identified at the Catholic Medical Center Health System dermatology outpatient clinic in the period 2007–2020. A comparison of the study patients with age- and sex-matched controls (dermatology outpatients without PN) indicated that PN was associated with various comorbidities including chronic kidney disease (adjusted odds ratio (aOR), 1.48; 95% confidence interval (CI), 1.29–1.70), dyslipidemia (aOR, 1.88; 95% CI, 1.56–2.27), type 2 diabetes mellitus (aOR, 1.37; 95% CI, 1.22–1.54), arterial hypertension (aOR, 1.50; 95% CI, 1.30–1.73), autoimmune thyroiditis (aOR, 2.43; 95% CI, 1.42–4.16), non-Hodgkin’s lymphoma (aOR, 1.95; 95% CI, 1.23–3.07), and atopic dermatitis (aOR, 2.16, 95% CI, 1.91–2.45). Regarding prescription patterns, topical steroids were most favored, followed by topical calcineurin inhibitors; oral antihistamines were the most preferred systemic agent for PN. PN is a relatively rare but significant disease among Korean dermatology outpatients with a high comorbidity burden compared to dermatology outpatients without PN. There is great need for breakthroughs in PN treatment.
Hearing Loss in Beta-Thalassemia: Systematic Review
Authors: Tartaglione Immacolata , Carfora Roberta , Brotto Davide , Barillari Maria Rosaria , Costa Giuseppe , Perrotta Silverio , Manara Renzo
Published: December 2021

In the last half century, the life expectancy of beta-thalassemia patients has strikingly increased mostly due to regular blood transfusions and chelation treatments. The improved survival, however, has allowed for the emergence of comorbidities, such as hearing loss, with a non-negligible impact on the patients’ quality of life. This thorough review analyzes the acquired knowledge regarding hearing impairment in this hereditary hemoglobinopathy, aiming at defining its prevalence, features, course, and possible disease- or treatment-related pathogenic factors. Following PRISMA criteria, we retrieved 60 studies published between 1979 and 2021. Diagnostic tools and criteria, forms of hearing impairment, correlations with beta-thalassemia phenotypes, age and sex, chelation treatment and laboratory findings including iron overload, were carefully searched, analyzed and summarized. In spite of the relatively high number of studies in the last 40 years, our knowledge is rather limited, and large prospective studies with homogeneous diagnostic tools and criteria are required to define all the aforementioned issues. According to the literature, the overall prevalence rate of hearing impairment is 32.3%; age, sex, and laboratory findings do not seem to correlate with hearing deficits, while the weak relationship with clinical phenotype and chelation treatment seems to highlight the presence of further yet to be identified pathogenic factors.
Metoclopramide and Propofol to Prevent Nausea and Vomiting during Cesarean Section under Spinal Anesthesia: A Randomized, Placebo-Controlled, Double-Blind Trial
Authors: Mokini Zhirajr , Genocchio Valentina , Forget Patrice , Petrini Flavia
Published: December 2021

Background: Intra-operative nausea, vomiting and retching (NVR) are frequently associated with subarachnoid anesthesia (SA) in women undergoing cesarean section (CS). In this study performed in women undergoing CS under SA with a risk factor control strategy, we compared saline (placebo), propofol, metoclopramide and both drugs to prevent NVR. Methods: We recorded NVR events in 110 women undergoing CS who were randomized after umbilical cord clamping to receive saline (S; n = 27), metoclopramide 10 mg (M; n = 28), propofol 1 mg/kg/h (P; n = 27) or both drugs (PM; n = 28). Results: The proportion of women with intra-operative nausea was: S: 17/27 (63%); P: 15/27 (56%); M: 13/28 (46%); PM: 6/28 (21%) (p = 0.012, Cramér’s V = 0.31 (large effect). The proportion of women with intra-operative vomiting/retching was: S: 9/27 (33%); M: 7/27 (25%); P: 3/28 (11%); PM 2/28 (7%) (p = 0.049, Cramér’s V = 0.26 (medium effect). Post-hoc multiple comparisons revealed a significant reduction in NVR episodes and NRS scores between the PM group and control. Sedation scores did not differ among groups. Conclusion: In women undergoing CS under SA with a risk factor control strategy, combined propofol and metoclopramide reduce nausea and vomiting.
Technical–Economic Feasibility Analysis of Subsea Shuttle Tanker
Authors: Xing Yihan , Santoso Tan Aditya Dwi , Ma Yucong
Published: December 2021

This paper presents the technical and economic feasibility analysis of the subsea shuttle tanker (SST). The SST is proposed as an alternative to subsea pipelines and surface tankers with the primary purpose of transporting CO2 autonomously underwater from onshore facilities to subsea wells for direct injection at marginal subsea fields. In contrast to highly weather-dependent surface tanker operations, the SST can operate in any condition underwater. The technical–economic analysis is performed in two steps. First, the SST’s technical feasibility is evaluated by investigating designs with lower and higher capacities. The purpose is to observe the appearance of technical limits (if present) when the SST is scaled down or up in size. Second, an economic analysis is performed using the well-reviewed cost models from the publicly available Zero Emissions Platform (ZEP) and Maritime Un-manned Navigation through Intelligence in Networks (MUNIN) D9.3 reports. The scenarios considered are CO2 transport volumes of 1 to 20 million tons per annum (mtpa) with transport distances of 180 km to 1500 km in which the cost per ton of CO2 is compared between offshore pipelines, crewed/autonomous tanker ships, and SST. The results show that SSTs with cargo capacities 10,569 m3, 23,239 m3, and 40,730 m3 are technically feasible. Furthermore, the SSTs are competitive for short and intermediate distances of 180–750 km and smaller CO2 volumes of 1–2.5 mtpa. Lastly, it is mentioned that the SST design used the DNVGL Rules for Classification for Naval Vessels, Part 4 Sub-surface ships, Chapter 1 Submarine, DNVGL-RU-NAVAL-Pt4Ch1, which is primarily catered towards military submarine design. It is expected that a dedicated structural design code that is optimized for the SST would reduce the structural weight and corresponding capital expenditure (CAPEX).
Antifungal Resistance in Clinical Isolates of Candida glabrata in Ibero-America
Authors: Martínez-Herrera Erick , Frías-De-León María Guadalupe , Hernández-Castro Rigoberto , García-Salazar Eduardo , Arenas Roberto , Ocharan-Hernández Esther , Rodríguez-Cerdeira Carmen
Published: December 2021

In different regions worldwide, there exists an intra-and inter-regional variability in the rates of resistance to antifungal agents in Candida glabrata, highlighting the importance of understanding the epidemiology and antifungal susceptibility profiles of C. glabrata in each region. However, in some regions, such as Ibero-America, limited data are available in this context. Therefore, in the present study, a systematic review was conducted to determine the antifungal resistance in C. glabrata in Ibero-America over the last five years. A literature search for articles published between January 2015 and December 2020 was conducted without language restrictions, using the PubMed, Embase, Cochrane Library, and LILACS databases. The search terms that were used were “Candida glabrata” AND “antifungal resistance” AND “Country”, and 22 publications were retrieved from different countries. The use of azoles (fluconazole, itraconazole, voriconazole, posaconazole, isavuconazole, ketoconazole, and miconazole) varied between 4.0% and 100%, and that of echinocandins (micafungin, caspofungin, and anidulafungin) between 1.1% and 10.0%. The limited information on this subject in the region of Ibero-America emphasizes the need to identify the pathogens at the species level and perform antifungal susceptibility tests that may lead to the appropriate use of these drugs and the optimal doses in order to avoid the development of antifungal resistance or multi-resistance.
Development of a Design Methodology for Cloud Distributed Control Systems of Mobile Robots
Authors: Sechenev Semyon , Ryadchikov Igor , Gusev Alexander , Lampezhev Abas , Nikulchev Evgeny
Published: December 2021

This article addresses the problem of cloud distributed control systems development for mobile robots. The authors emphasize the lack of a design methodology to guide the process of the development in accordance with specific technical and economic requirements for the robot. On the analysis of various robots architectures, the set of the nine most significant parameters are identified to direct the development stage by stage. Based on those parameters, the design methodology is proposed to build a scalable three-level cloud distributed control system for a robot. The application of the methodology is demonstrated on the example of AnyWalker open source robotics platform. The developed methodology is also applied to two other walking robots illustrated in the article.
Working Mode and Physical Activity as Factors Determining Stress and Sleep Quality during COVID-19 Pandemic Lockdown in Poland
Authors: Lipert Anna , Musiał Kamila , Rasmus Paweł
Published: December 2021

The coronavirus pandemic and related government restrictions have a significant impact on peoples’ everyday functioning and working, which influences their physical and mental health. The aim of the study was to examine the associations between stress and sleep quality of people of different working modes: working in the workplace (WP), working remotely (RW), and nonworking (NW) in relation to their physical activity (PA) during COVID-19 pandemic lockdown in Poland. It was an online survey performed during governmental lockdown in April 2020. The data were collected form 1959 adults using International Physical Activity Questionnaire—Short Form (IPAQ-SF), Pittsburgh Sleep Quality Index (PSQI), and Perceived Stress Scale (PSS). The conducted analysis included t-Student test, analysis of variance (ANOVA), and mediation analysis (MANOVA). A moderate level of stress was reported in 57% of participants, and 34% of them reported a high stress level. Poor sleep quality was reported in 64% of participants. Total PA performed daily was, on average, 184.8 ± 170.5 min/day for WP, 120.6 ± 124.4 min/day for RW, and 124.6 ± 114.7 min/day for NW (p < 0.001). There was a relationship observed between the stress and sleep quality vs. PA habit and working mode, with p < 0.05. Being physically active can be beneficial to perceive less stress and sleep disturbances influencing sleep quality, especially in remotely or nonworking people. Planning future pandemic restrictions, the policymakers should be aware of the appropriate guidelines of work planning and PA recommendations for people of different working modes.
Role of a Dual Glucose-Dependent Insulinotropic Peptide (GIP)/Glucagon-like Peptide-1 Receptor Agonist (Twincretin) in Glycemic Control: From Pathophysiology to Treatment
Authors: Pelle Maria Chiara , Provenzano Michele , Zaffina Isabella , Pujia Roberta , Giofrè Federica , Lucà Stefania , Andreucci Michele , Sciacqua Angela , Arturi Franco
Published: December 2021

Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are two gut hormones, defined incretins, responsible for the amplification of insulin secretion after oral glucose intake. Unlike GLP-1, GIP has little acute effect on insulin secretion and no effect on food intake; instead it seems that the GIP may be an obesity-promoting hormone. In patients with type2 diabetes mellitus (T2DM) some studies found a downregulation of GIP receptors on pancreatic β cells caused by hyperglycemic state, but the glucagonotropic effect persisted. Agonists of the receptor for the GLP-1 have proven successful for the treatment of diabetes, since they reduce the risk for cardiovascular and renal events, but the possible application of GIP as therapy for T2DM is discussed. Moreover, the latest evidence showed a synergetic effect when GIP was combined with GLP-1 in monomolecular co-agonists. In fact, compared with the separate infusion of each hormone, the combination increased both insulin response and glucagonostatic response. In accordance with theseconsiderations, a dual GIP/GLP-1receptor agonist, i.e., Tirzepatide, known as a “twincretin” had been developed. In the pre-clinical trials, as well as Phase 1–3 clinical trials, Tirzepatideshowedpotent glucose lowering and weight loss effects within an acceptable safety.
Synthesis and Characterisation of 1,1′-{[3,5-Bis(dodecyloxy-carbonyl)-4-(thiophen-3-yl)-1,4-dihydropyridine-2,6-diyl]bis-(methylene)}bis(pyridin-1-ium) Dibromide
Authors: Rucins Martins , Pajuste Karlis , Plotniece Aiva , Pikun Nadiia , Rodik Roman , Vyshnevskiy Sergiy , Sobolev Arkadij
Published: December 2021

In the present work, construction of double-charged cationic amphiphilic 1,1′-{[3,5-bis(dodecyl¬oxy-carbonyl)-4-(thiophen-3-yl)-1,4-dihydropyridine-2,6-diyl]bis-(methylene)}bis(pyridin-1-ium) dibromide (7) was performed in four steps. Dodecyl 3-oxobutanoate (1) was condensed with thiophene-3-carbaldehyde (2) which was necessary for Hantzsch cyclisation dodecyl (E/Z)-3-oxo-2-(thiophen-3-ylmethylene)butanoate (3). Two-component Hantzsch type cyclisation of dodecyl (E/Z)-3-aminobut-2-enoate (4) and dodecyl (E/Z)-3-oxo-2-(thiophen-3-ylmethylene)butanoate (3) gave 3,5-bis(dodecyloxycarbonyl)-2,6-dimethyl-4-(thiophen-3-yl)-1,4-dihydropyridine (5). Bromination of compound 5 followed by nucleophilic substitution of bromine with pyridine gave the desired cationic amphiphilic 1,4-dihydropyridine 7. The obtained target compound 7 and new intermediates 3, 5 and 6 were fully characterised by IR, UV, 1H NMR, 13C NMR, HRMS or microanalysis. Characterisation of nanoparticles formed by the cationic 1,4-dihydropyridine 7 in an aqueous solution was performed by DLS measurements.
Experimental Investigation of the TRM-to-Masonry Bond after Exposure to Elevated Temperatures: Cementitious and Alkali-Activated Matrices of Various Densities
Authors: Askouni Paraskevi D. , Papanicolaou Catherine (Corina) G. , Azdejkovic Lazar
Published: December 2021

Limited research has focused on the effect of high temperatures on the textile-reinforced mortar (TRM)-to-masonry bond. In this study, masonry prisms that were furnished with double-layered TRM strips were tested under shear bond conditions after their exposure to 200 °C and 400 °C for 1 h using the single-lap/single-prism setup. A total of four TRM systems were applied sharing the same type of textile –a dry AR glass fiber one– and different matrices: two cementitious matrices, namely a normal-weight (TRCNM) and a lightweight (TRCLM) one, and two counterpart alkali-activated matrices (TRAANM and TRAALM) based on metakaolin and fly ash. Specimens’ exposure to elevated temperatures did not alter their failure mode which was due to the sleeve fibers’ rupture along with core fibers’ slippage from the mortar. The residual bond capacity of the TRM systems decreases almost linearly with increasing exposure temperature. The alkali-activated textile reinforced mortars outperformed their cement-based counterparts in terms of bond strength at every temperature. All systems retained close to 50% of their original shear bond strength after heating at 400 °C. Per the type of binder, lightweight matrices resulted in either comparable (cement-based systems) or better (alkali-activated systems) heat protection at the TRM/masonry interface.
A Narrative Review of u-HA/PLLA, a Bioactive Resorbable Reconstruction Material: Applications in Oral and Maxillofacial Surgery
Authors: Ngo Huy Xuan , Bai Yunpeng , Sha Jingjing , Ishizuka Shinji , Toda Erina , Osako Rie , Kato Akira , Morioka Reon , Ramanathan Mrunalini , Tatsumi Hiroto , Okui Tatsuo , Kanno Takahiro
Published: December 2021

The advent of bioresorbable materials to overcome limitations and replace traditional bone-reconstruction titanium-plate systems for bone fixation, thus achieving greater efficiency and safety in medical and dental applications, has ushered in a new era in biomaterial development. Because of its bioactive osteoconductive ability and biocompatibility, the forged composite of uncalcined/unsintered hydroxyapatite and poly L-lactic acid (u-HA/PLLA) has attracted considerable interest from researchers in bone tissue engineering, as well as from clinicians, particularly for applications in maxillofacial reconstructive surgery. Thus, various in vitro studies, in vivo studies, and clinical trials have been conducted to investigate the feasibility and weaknesses of this biomaterial in oral and maxillofacial surgery. Various technical improvements have been proposed to optimize its advantages and limit its disadvantages. This narrative review presents an up-to-date, comprehensive review of u-HA/PLLA, a bioactive osteoconductive and bioresorbable bone-reconstruction and -fixation material, in the context of oral and maxillofacial surgery, notably maxillofacial trauma, orthognathic surgery, and maxillofacial reconstruction. It simultaneously introduces new trends in the development of bioresorbable materials that could used in this field. Various studies have shown the superiority of u-HA/PLLA, a third-generation bioresorbable biomaterial with high mechanical strength, biocompatibility, and bioactive osteoconductivity, compared to other bioresorbable materials. Future developments may focus on controlling its bioactivity and biodegradation rate and enhancing its mechanical strength.
Viscoelastic Polyurethane Foams with Reduced Flammability and Cytotoxicity
Authors: Okrasa Małgorzata , Leszczyńska Milena , Sałasińska Kamila , Szczepkowski Leonard , Kozikowski Paweł , Nowak Adriana , Szulc Justyna , Adamus-Włodarczyk Agnieszka , Gloc Michał , Majchrzycka Katarzyna , Ryszkowska Joanna
Published: December 2021

Consistent and proper use of respiratory protective devices (RPD) is one of the essential actions that can be taken to reduce the risk of exposure to airborne hazards, i.e., biological and nonbiological aerosols, vapours, and gases. Proper fit of the facepiece and comfort properties of RPDs play a crucial role in effective protection and acceptance of RPDs by workers. The objective of the present paper was to develop viscoelastic polyurethane foams for use in RPD seals characterised by proper elasticity, allowing for the enhancement of the device fit to the face and the capability of removing moisture from the skin in order to improve the comfort of RPD use. Moreover, it was pivotal to ensure the non-flammability of the foams, as well as a simultaneous reduction in their cytotoxicity. The obtained foams were characterised using scanning electron microscopy, infrared spectroscopy, thermogravimetry, and differential scanning calorimetry. Measurements also involved gel fraction, apparent density, compression set, rebound resilience, wettability, flammability, and cytotoxicity. The results are discussed in the context of the impact of modifications to the foam formulation (i.e., flame-retardant type and content) on the desired foam properties. The test results set directions for future works aimed to develop viscoelastic polyurethane foams that could be applied in the design of respiratory protective devices.
Effect of Accelerators on the Workability, Strength, and Microstructure of Ultra-High-Performance Concrete
Authors: Su Yonghua , Luo Biao , Luo Zhengdong , Huang He , Li Jianbao , Wang Dehui
Published: December 2021

The preparation of ultra-high-performance concrete (UHPC) with both high-early-strength and good workability contributes to further promotion of its development and application. This study investigated the effects of different accelerators (SM, alkaline powder accelerator; SF, alkaline powder accelerator containing fluorine; and AF, alkali-free liquid accelerator containing fluorine) on the workability and strength properties of UHPC. The microstructure of UHPC was also characterized by using XRD and SEM. Several dosage levels of accelerators (2%, 4%, 6%, and 8% by mass) were selected. The results indicate that the setting time and fluidity of UHPC are gradually decreased with an increase in accelerators dosage. Compared with fluorine-containing SF/AF, fluorine-free SM evidently facilitates UHPC early strength gain speed. However, the fluorine-containing accelerators have a higher 28 d strength ratio, especially AF. The maximum compressive and flexural strength ratios are obtained at a dosage of 6%, which are 95.5% and 98.3%, respectively. XRD and SEM tests further reveal the effect of different accelerators on the macroscopic properties of UHPC from the micro level.
Effects of Currents on Human Freestyle and Breaststroke Swimming Analyzed by a Rigid-Body Dynamic Model
Authors: Bao Yinxiang , Fang Hongbin , Xu Jian
Published: December 2021

Swimming is a kind of complex locomotion that involves the interaction between the human body and the water. Here, to examine the effects of currents on the performance of freestyle and breaststroke swimming, a multi-body Newton-Euler dynamic model of human swimming is developed. The model consists of 18 rigid segments, whose shapes and geometries are determined based on the measured data from 3D scanning, and the fluid drags in consideration of the current are modeled. By establishing the interrelations between the fluid moments and the swimming kinematics, the underlying mechanism that triggers the turning of the human body is uncovered. Through systematic parametric analyses, the effects of currents on swimming performance (including the human body orientation, swimming direction, swimming speed, and propulsive efficiency) are elucidated. It reveals that the current would turn the human body counterclockwise in freestyle swimming, while clockwise in breaststroke swimming (which means that from the top view, the human trunk, i.e., the vector pointing from the bottom of feet to the top of the head, rotates counterclockwise or clockwise). Moreover, for both strokes, there exists a critical current condition, beyond which, the absolute swimming direction will be reversed. This work provides a wealth of fundamental insights into the swimming dynamics in the presence of currents, and the proposed modeling and analysis framework is promising to be used for analyzing the human swimming behavior in open water.
Monocular 3D Object Detection Based on Uncertainty Prediction of Keypoints
Authors: Chen Mu , Zhao Huaici , Liu Pengfei
Published: December 2021

Three-dimensional (3D) object detection is an important task in the field of machine vision, in which the detection of 3D objects using monocular vision is even more challenging. We observe that most of the existing monocular methods focus on the design of the feature extraction framework or embedded geometric constraints, but ignore the possible errors in the intermediate process of the detection pipeline. These errors may be further amplified in the subsequent processes. After exploring the existing detection framework of keypoints, we find that the accuracy of keypoints prediction will seriously affect the solution of 3D object position. Therefore, we propose a novel keypoints uncertainty prediction network (KUP-Net) for monocular 3D object detection. In this work, we design an uncertainty prediction module to characterize the uncertainty that exists in keypoint prediction. Then, the uncertainty is used for joint optimization with object position. In addition, we adopt position-encoding to assist the uncertainty prediction, and use a timing coefficient to optimize the learning process. The experiments on our detector are conducted on the KITTI benchmark. For the two levels of easy and moderate, we achieve accuracy of 17.26 and 11.78 in AP3D, and achieve accuracy of 23.59 and 16.63 in APBEV, which are higher than the latest method KM3D.
Inverse Result of Approximation for the Max-Product Neural Network Operators of the Kantorovich Type and Their Saturation Order
Authors: Cantarini Marco , Coroianu Lucian , Costarelli Danilo , Gal Sorin G. , Vinti Gianluca
Published: December 2021

In this paper, we consider the max-product neural network operators of the Kantorovich type based on certain linear combinations of sigmoidal and ReLU activation functions. In general, it is well-known that max-product type operators have applications in problems related to probability and fuzzy theory, involving both real and interval/set valued functions. In particular, here we face inverse approximation problems for the above family of sub-linear operators. We first establish their saturation order for a certain class of functions; i.e., we show that if a continuous and non-decreasing function f can be approximated by a rate of convergence higher than 1/n, as n goes to +∞, then f must be a constant. Furthermore, we prove a local inverse theorem of approximation; i.e., assuming that f can be approximated with a rate of convergence of 1/n, then f turns out to be a Lipschitz continuous function.
A Hybrid Novel Fuzzy MCDM Method for Comprehensive Performance Evaluation of Pumped Storage Power Station in China
Authors: You Peipei , Liu Sijia , Guo Sen
Published: December 2021

Considering the goals of carbon peaking and carbon neutrality, along with their related policies, pumped storage power stations are set to develop quickly in China. The comprehensive performance of pumped storage power stations must urgently be evaluated, which can help investors in decision making and provide a reference for policymakers. In this paper, a hybrid novel fuzzy multicriteria decision-making (MCDM) method combining the fuzzy best worst method (BWM) and fuzzy TOPSIS was proposed for the comprehensive performance evaluation of pumped storage power stations in China. The fuzzy BWM was utilized to determine the criteria weights describing the comprehensive performance of pumped storage power stations, while the fuzzy TOPSIS was used to rank the comprehensive performance of pumped storage power stations. The index system for the comprehensive performance evaluation of pumped storage power stations in China incorporated economic, social, and environmental aspects. The comprehensive performance of four pumped storage power stations in China was empirically evaluated using the proposed hybrid novel fuzzy MCDM method, and the results indicate that pumped storage power station PSPS2 exhibited the best comprehensive performance, followed by pumped storage power stations PSPS1 and PSPS4, whereas pumped storage power station PSPS3 had the worst comprehensive performance. A sensitivity analysis and comparative analysis were also conducted. The results indicate that the proposed hybrid novel fuzzy MCDM method, combining the fuzzy BWM and fuzzy TOPSIS for comprehensive performance evaluation of pumped storage power stations, is robust and effective.
Some New Hermite-Hadamard-Fejér Fractional Type Inequalities for h-Convex and Harmonically h-Convex Interval-Valued Functions
Authors: Kalsoom Humaira , Latif Muhammad , Khan Zareen , Vivas-Cortez Miguel
Published: December 2021

In this article, firstly, we establish a novel definition of weighted interval-valued fractional integrals of a function Υ˘ using an another function ϑ(ζ˙). As an additional observation, it is noted that the new class of weighted interval-valued fractional integrals of a function Υ˘ by employing an additional function ϑ(ζ˙) characterizes a variety of new classes as special cases, which is a generalization of the previous class. Secondly, we prove a new version of the Hermite-Hadamard-Fejér type inequality for h-convex interval-valued functions using weighted interval-valued fractional integrals of a function Υ˘ according to another function ϑ(ζ˙). Finally, by using weighted interval-valued fractional integrals of a function Υ˘ according to another function ϑ(ζ˙), we are establishing a new Hermite-Hadamard-Fejér type inequality for harmonically h-convex interval-valued functions that is not previously known. Moreover, some examples are provided to demonstrate our results.