bluuebunny/crossref_metadata_2025 huggingface dataset:
Ionomic Variation Among Tissues in Fallow Deer (Dama dama) by Sex and Age
Authors: Wenting Elke , Siepel Henk , Christerus Melanie , Jansen Patrick A.
Published: June 2023

(1) In mammals, the mineral nutrient and trace elemental composition of the body - the ionome - differs among individuals. It has been hypothesized that these differences may be related to age and sex, both for ecotoxic and essential elements. (2) We investigated whether and how intraspecific ionomic variation is related to age and sex in Fallow deer (Dama dama). We tested the predictions that concentrations of ecotoxic elements increase with age, that ionomic variation is lower among young individuals than among older individuals, and that reproductive females (does) have the lowest concentrations of essential elements. (3) Culled animals of different sex and age were obtained from a single protected area. The animals were dissected to collect 13 tissues, and concentrations of 22 different elements were measured in a sample of each tissue. (4) We described substantial ionomic variation between individuals. Some of this variation was related to age and sex, as predicted. Based on the limited existing knowledge on chemical element allocation and metabolism in the body, sex-related differences were more difficult to interpret than age-related differences. Since reference values are absent, we could not judge about the consequences of the elemental values that we found. (5) More extensive ionomic surveys, based on a wide range of elements and tissues, are needed to enlarge the understanding of within-species ionomic variation and potential biological, ecological, and metabolic consequences.
Capicua (CIC) mutations in gliomas in association with MAPK activation for exposing a potential therapeutic target
Authors: Darabi Sourat , Xiu Joanne , Samec Timothy , Kesari Santosh , Carrillo Jose , Aulakh Sonikpreet , Walsh Kyle M. , Sengupta Soma , Sumrall Ashley , Spetzler David , Glantz Michael , Demeure Michael J.
Published: June 2023

Gliomas are the most prevalent neurological cancer in the USA and care modalities are not able to effectively combat these aggressive malignancies. Identifying new, more effective treatments require a deep understanding of the complex genetic variations and relevant pathway associations behind these cancers. Drawing connections between gene mutations with a responsive genetic target can help drive therapy selections to enhance patient survival. We have performed extensive molecular profiling of the Capicua gene (CIC), a tumor and transcriptional suppressor gene, and its mutation prevalence in reference to MAPK activation within clinical glioma tissue. CIC mutations occur far more frequently in oligodendroglioma (52.1%) than in low-grade astrocytoma or glioblastoma. CIC-associated mutations were observed across all glioma subtypes, and MAPK-associated mutations were most prevalent in CIC wild-type tissue regardless of the glioma subtype. MAPK activation, however, was enhanced in CIC-mutated oligodendroglioma. The totality of our observations reported supports the use of CIC as a relevant genetic marker for MAPK activation. Identification of CIC mutations, or lack thereof, can assist in selecting, implementing, and developing MEK/MAPK-inhibitory trials to improve patient outcomes potentially.
Development of generalizable automatic sleep staging using heart rate and movement based on large databases
Authors: Lee Joonnyong , Kim Hee Chan , Lee Yu Jin , Lee Saram
Published: June 2023

Purpose

With the advancement of deep neural networks in biosignals processing, the performance of automatic sleep staging algorithms has improved significantly. However, sleep staging using only non-electroencephalogram features has not been as successful, especially following the current American Association of Sleep Medicine (AASM) standards. This study presents a fine-tuning based approach to widely generalizable automatic sleep staging using heart rate and movement features trained and validated on large databases of polysomnography.

Methods

A deep neural network is used to predict sleep stages using heart rate and movement features. The model is optimized on a dataset of 8731 nights of polysomnography recordings labeled using the Rechtschaffen & Kales scoring system, and fine-tuned to a smaller dataset of 1641 AASM-labeled recordings. The model prior to and after fine-tuning is validated on two AASM-labeled external datasets totaling 1183 recordings. In order to measure the performance of the model, the output of the optimized model is compared to reference expert-labeled sleep stages using accuracy and Cohen’s κ as key metrics.

Results

The fine-tuned model showed accuracy of 76.6% with Cohen’s κ of 0.606 in one of the external validation datasets, outperforming a previously reported result, and showed accuracy of 81.0% with Cohen’s κ of 0.673 in another external validation dataset.

Conclusion

These results indicate that the proposed model is generalizable and effective in predicting sleep stages using features which can be extracted from non-contact sleep monitors. This holds valuable implications for future development of home sleep evaluation systems.
Therapeutic effects of isoquercetin on ovariectomy-induced osteoporosis in mice
Authors: Wu Mengjing , Qin Mengyu , Wang Xian
Published: June 2023

Bone marrow mesenchymal stem cells (BMSCs) are non-hematopoietic multipotent stem cells capable of differentiating into mature cells. Isoquercetin, an extract from natural sources, has shown promise as a potential treatment for osteoporosis. To investigate the therapeutic effects of isoquercetin on osteoporosis, bone marrow mesenchymal stem cells (BMSCs) were cultured in vitro, and osteogenesis or adipogenesis was induced in the presence of isoquercetin for 14 days. We evaluated cell viability, osteogenic and adipogenic differentiation, as well as mRNA expression levels of Runx2, Alpl, and OCN in osteoblasts, and mRNA expression levels of Pparγ, Fabp4, and Cebpα in adipocytes. The results showed that isoquercetin dose-dependently increased cell viability and promoted osteogenic differentiation, as evidenced by Alizarin Red and alkaline phosphatase staining and mRNA expression levels of Runx2, Alpl, and OCN in osteoblasts (P < 0.05). In contrast, isoquercetin inhibited adipogenic differentiation and decreased the mRNA expression levels of Pparγ, Fabp4, and Cebpα in adipocytes (P < 0.05). In vivo, isoquercetin treatment increased bone quantity and density in an osteoporosis model mice group, as determined by μCT scanning and immunohistochemistry (P < 0.05). These findings suggest that isoquercetin may have therapeutic potential for osteoporosis by promoting the proliferation and differentiation of BMSCs towards osteoblasts while inhibiting adipogenic differentiation.

Graphical Abstract
Centralisers, complex reflection groups and actions in the Weyl group $$E_6$$
Authors: Niblo Graham A. , Plymen Roger , Wright Nick
Published: June 2023

The compact, connected Lie group $$E_6$$

E
6

admits two forms: simply connected and adjoint type. As we previously established, the Baum–Connes isomorphism relates the two Langlands dual forms, giving a duality between the equivariant K-theory of the Weyl group acting on the corresponding maximal tori. Our study of the $$A_n$$

A
n

case showed that this duality persists at the level of homotopy, not just homology. In this paper we compute the extended quotients of maximal tori for the two forms of $$E_6$$

E
6

, showing that the homotopy equivalences of sectors established in the $$A_n$$

A
n

case also exist here, leading to a conjecture that the homotopy equivalences always exist for Langlands dual pairs. In computing these sectors we show that centralisers in the $$E_6$$

E
6

Weyl group decompose as direct products of reflection groups, generalising Springer’s results for regular elements, and we develop a pairing between the component groups of fixed sets generalising Reeder’s results. As a further application we compute the K-theory of the reduced Iwahori-spherical $$C^*$$

C
∗

-algebra of the p-adic group $$E_6$$

E
6

, which may be of adjoint type or simply connected.
Electromechanical therapy in diabetic foot ulcers patients: A systematic review and meta-analysis
Authors: Rathnayake Ayeshmanthe , Saboo Apoorva , Vangaveti Venkat , Malabu Usman
Published: June 2023

Purpose

Diabetic foot ulcer (DFU) is one of the most devastating and troublesome consequences of diabetes. The current therapies are not always effective because of the complicated aetiology and interactions of local and systemic components in DFU. However, adjunctive therapy (electromechanical therapy) has become the latest modality in recent years, although there is a lack of significant research to support its utilization as a treatment standard. The purpose of this systematic research was to review the literature on the application of electromechanical therapies in the healing of DFUs.

Methods

For this systematic review, we searched PubMed, Medline, EmBase, the Cochrane library, and Google Scholar for the most current research (1990–2022) on electromechanical therapies for DFUs. We used the PICO method (where P is population, I is intervention, C is comparator/control, and O is outcome for our study) to establish research question with the terms [Electromechanical therapy OR Laser therapy OR photo therapy OR Ultrasound therapy OR Shockwave therapy] AND [diabetic foot ulcers OR diabetes] were used as search criteria. Searches were restricted to English language articles only. Whereas, Cochrane handbook of “Systematic Reviews of Interventions” with critical appraisal for medical and health sciences checklist for systematic review was used for risk of bias assessment. There were 39 publications in this study that were deemed to be acceptable. All the suitably selected studies include 1779 patients.

Results

The meta-analysis of 15 included research articles showed the overall effect was significant (P = 0.0002) thus supporting experimental groups have improvement in the DFUs healing in comparison to the control group.

Conclusion

This systematic review and meta-analysis revealed electromechanical treatments are significantly viable options for patients with DFUs. Electromechanical therapy can considerably reduce treatment ineffectiveness, accelerate healing, and minimize the time it takes for complete ulcer healing.
Clinical factors for predicting cardiovascular risk, need for renal replacement therapy, and mortality in patients with non–dialysis-dependent stage 3–5 chronic kidney disease from the Salford Kidney Study
Authors: Filipa Alexandre Ana , Stoelzel Matthias , Kiran Amit , Garcia-Hernandez Alberto , Morga Antonia , Kalra Philip A.
Published: June 2023

Background

Established cardiovascular risk assessment tools lack chronic kidney disease–specific clinical factors and may underestimate cardiovascular risk in non–dialysis-dependent chronic kidney disease (CKD) patients.

Methods

A retrospective analysis of a cohort of patients with stage 3–5 non–dialysis-dependent chronic kidney disease in the Salford Kidney Study (UK, 2002–2016) was performed. Multivariable Cox regression models with backward selection and repeated measures joint models were used to evaluate clinical risk factors associated with cardiovascular events (individual and composite cardiovascular major adverse cardiovascular events), mortality (all-cause and cardiovascular-specific), and need for renal replacement therapy. Models were established using 70% of the cohort and validated on the remaining 30%. Hazard ratios ([95% CIs]) were reported.

Results

Among 2192 patients, mean follow-up was 5.6 years. Cardiovascular major adverse cardiovascular events occurred in 422 (19.3%) patients; predictors included prior history of diabetes (1.39 [1.13–1.71]; P = 0.002) and serum albumin reduction of 5 g/L (1.20 [1.05–1.36]; P = 0.006). All-cause mortality occurred in 740 (33.4%) patients, median time to death was 3.8 years; predictors included reduction of estimated glomerular filtration of 5 mL/min/1.73 m2 (1.05 [1.01–1.08]; P = 0.011) and increase of phosphate of 0.1 mmol/L (1.04 [1.01–1.08]; P = 0.021), whereas a 10 g/L hemoglobin increase was protective (0.90 [0.85–0.95]; P < 0.001). In 394 (18.0%) patients who received renal replacement therapy, median time to event was 2.3 years; predictors included halving of estimated glomerular filtration rate (3.40 [2.65–4.35]; P < 0.001) and antihypertensive use (1.23 [1.12–1.34]; P < 0.001). Increasing age, albumin reduction, and prior history of diabetes or cardiovascular disease were risk factors for all outcomes except renal replacement therapy.

Conclusions

Several chronic kidney disease–specific cardiovascular risk factors were associated with increased mortality and cardiovascular event risk in patients with non–dialysis-dependent chronic kidney disease.

Graphical abstract
The concepts and origins of cell mortality
Authors: Durand Pierre M. , Ramsey Grant
Published: June 2023

Organismal death is foundational to the evolution of life, and many biological concepts such as natural selection and life history strategy are so fashioned only because individuals are mortal. Organisms, irrespective of their organization, are composed of basic functional units—cells—and it is our understanding of cell death that lies at the heart of most general explanatory frameworks for organismal mortality. Cell death can be exogenous, arising from transmissible diseases, predation, or other misfortunes, but there are also endogenous forms of death that are sometimes the result of adaptive evolution. These endogenous forms of death—often labeled programmed cell death, PCD—originated in the earliest cells and are maintained across the tree of life. Here, we consider two problematic issues related to PCD (and cell mortality generally). First, we trace the original discoveries of cell death from the nineteenth century and place current conceptions of PCD in their historical context. Revisions of our understanding of PCD demand a reassessment of its origin. Our second aim is thus to structure the proposed origin explanations of PCD into coherent arguments. In our analysis we argue for the evolutionary concept of PCD and the viral defense-immunity hypothesis for the origin of PCD. We suggest that this framework offers a plausible account of PCD early in the history of life, and also provides an epistemic basis for the future development of a general evolutionary account of mortality.
Pulling through together: social media response trajectories in disaster-stricken communities
Authors: Maldeniya Danaja , De Choudhury Munmun , Garcia David , Romero Daniel M.
Published: June 2023

Disasters are extraordinary shocks that disrupt every aspect of the community life. Lives are lost, infrastructure is destroyed, the social fabric is torn apart, and people are left with physical and psychological trauma. In the aftermath of a disaster, communities begin the collective process of healing, grieving losses, repairing damage, and adapting to a new reality. Previous work has suggested the existence of a series of prototypical stages through which such community responses evolve. As social media have become more widely used, affected communities have increasingly adopted them to express, navigate, and build their response due to the greater visibility and speed of interaction that these platforms afford. In this study, we ask if the behavior of disaster-struck communities on social media follows prototypical patterns and what relationship, if any, these patterns may have with those established for offline behavior in previous work. Building on theoretical models of disaster response, we investigate whether, in the short term, community responses on social media in the aftermath of disasters follow a prototypical trajectory. We conduct our analysis using computational methods to model over 200 disaster-stricken U.S. communities. Community responses are measured in a range of domains, including psychological, social, and sense-making, and as multidimensional time series derived from the linguistic markers in tweets from those communities. We find that community responses on Twitter demonstrate similar response patterns across numerous social, aspirational, and physical dynamics. Additionally, through cluster analysis, we demonstrate that a minority of communities are characterized by more intense and enduring emotional coping strategies and sense-making. In this investigation of the relationship between community response and intrinsic properties of disasters, we reveal that the severity of the impact makes the deviant trajectory more likely, while the type and duration of a disaster are not associated with it.
The Spectral Einstein functional and Kastler–Kalau–Walze type theorems
Authors: Yang Yuchen , Wu Tong
Published: June 2023

In this paper, on the basis of defining the spectral Einstein functional associated with the Dirac operator for manifolds with boundary, we prove Kastler–Kalau–Walze type theorem for the spectral Einstein functional associated with the Dirac operator on low-dimensional manifolds with boundary.
The Book of Amos and its Audiences
Authors: Davis Andrew R.
Published: June 2023

Many studies of the prophetic books assume that a text's addressee and audience are one and the same. Sometimes this is the case, but some prophetic texts feature multiple addressees who cannot be collapsed into a single setting. In this book Andrew R. Davis examines examples of multiple addressees within the book of Amos and argues that they force us to expand our understanding of prophetic audiences. Drawing insight from studies of poetic address in other disciplines, Davis distinguishes between the addressee within the text and the actual audience outside the text. He combines in-depth poetic analysis with historical inquiry and shows the ways that the prophetic discourse of the book of Amos is triangulated among multiple audiences.
Of Moral Conduct
Authors: Audi Robert
Published: June 2023

In this book Robert Audi presents an original ethics of conduct, spanning moral theory, practical ethics, and theories of obligation and value. Conduct is determined not just by what we do, but also by why and how we do it. To integrate these dimensions of conduct, Audi clarifies the relation between intention and obligation, explains the difference between moral rightness and moral worth, and describes myriad manners of human actions. He also clarifies major moral standards such as justice, fidelity, beneficence, and liberty, and explores ethics from the perspectives of the theory of action, the epistemology of moral principles, the metaphysics of normative properties, and the value of human experiences. His concluding chapters offer a theory of reasons and values and propose an original theory of value.
Taking Children and Young People Seriously
Authors: Hedegaard Mariane , Edwards Anne
Published: June 2023

Children and young people are active agents with motives and intentions who can contribute to their social worlds. Taking children seriously involves both accessing their perspectives as they make sense of the world and working relationally with them to guide their motive orientations. In this book, Hedegaard and Edwards draw upon their own and others' research on children from birth to school leaving age to advocate for relational support for learners and to emphasise the caring aspects of this support. The authors provide a scholarly account of the cultural-historical underpinnings of their caring relational approach, while bringing these ideas to life through examples of practices in families and in more formal settings. Written for those who work with children and young people in varied capacities, this book reveals the knowledge and skills required for the subtle and reciprocal work of supporting the learning and development of children and young people.
English Victorian Churches
Authors: Curl James Stevens
Published: June 2023

Victorian churches were often of high quality, reflecting in physical terms the intense theological debates of the time. This highly-illustrated book by a leading authority describes many of the finest examples.
Edward J. Dent
Authors: Arrandale Karen
Published: June 2023

This first full biography of Edward J. Dent (1876-1957), Cambridge Professor of Music and foremost musicologist, tells the story of a remarkable man who played a crucial role in the formation of twentieth-century culture and cultural institutions.
Melody in the Dark
Authors: Wright Adrian
Published: June 2023

A comprehensive reassessment of British musical films 1946-1972 including 'King's Rhapsody', 'Beat Girl', 'The Tommy Steele Story', 'Rock You Sinners', 'The Golden Disc', and 'Oliver!'.
Production Function and Farmers’ Risk Aversion: A Certainty Equivalent-adjusted Production Function
Authors: Lien Gudbrand , Kumbhakar Subal C. , Mishra Ashok K.
Published: June 2023

Faced with risky yields and returns, risk-averse farmers require a premium to take risks. In this paper, we estimate individual farmers’ degrees of risk aversion to adjust for the risk premium in returns and to replace the farmers’ realized returns with their certainty equivalent returns in the production function. In that way, the effect of the inputs on returns will automatically be risk-adjusted, i.e., we obtain risk-adjusted marginal effects of inputs, which can be used in decision-making support of farmers’ input choices in production. Using farm-level data from organic basmati rice smallholders in India, we illustrate this method using nonparametric production functions. The results show that the input elasticities and returns-to-scale estimates change when the farmers’ degree of risk aversion is taken into consideration.
Clinical and Translational Science Personas: Expansion and use cases
Authors: Gonzales Sara , Champieux Robin , Contaxis Nicole , Denton Andrea H. , Hosseini Mohammad , Surkis Alisa , Wescott Annie , Holmes Kristi
Published: June 2023

Twelve evidence-based profiles of roles across the Clinical and Translational Science (CTS) workforce and two patient profiles were developed by CTS Personas collaborators in 2019 as part of the CTSA Program National Center for Data to Health (CD2H). Based on feedback received from the community, CTS Personas team members collaborated to produce five additional Personas to broaden representation of the CTS workforce and enhance the existing portfolio. This paper presents the rationale and methodology used in the latest CTS Personas initiative. This work also includes an implementation scenario incorporating multiple Personas. Using the new National Institutes of Health’s (NIH) Data Management and Sharing Policy as an example, we demonstrate how administrators, researchers, support staff, and all CTS collaborators can use the Personas to respond to this new policy while considering the needs of service providers and users, CTS employees with short- and long-term needs, and interdisciplinary perspectives.
The AfD within the AfD: Radical Right Intra-Party Competition and Ideational Change
Authors: Pytlas Bartek , Biehler Jan
Published: June 2023

The normalization of radical right (RR) politics fosters opportunities for RR parties, but can also facilitate intra-party conflicts over the ‘true’ version of the shared party ideology. Previous research has highlighted two factors that influence ideational change within RR parties: contextual conditions and the formal power of intra-party factions. Yet, surprisingly, the Alternative for Germany (AfD) progressively radicalized to the right and witnessed the increased influence of its extremist grouping Der Flügel, despite contextual normalization pressures and the grouping's lower formal power. Analysing three crucial conflicts within the AfD between 2013 and 2021, we show how intra-party competition additionally plays into nativist party radicalization. Flügel balanced contextual and ‘hard’ power disadvantages by fostering its ‘soft’ power as ‘the true party within the party’. Simultaneously, this power was cemented by more established AfD actors who used Flügel's ideas against other competitors for office. Our conclusions have important implications for comparative research on competition within and between RR parties.
Shock-induced aerobreakup of a polymeric droplet
Authors: Kumar Chandra Navin , Sharma Shubham , Basu Saptarshi , Kumar Aloke
Published: June 2023

Droplet atomization through aerobreakup is omnipresent in various natural and industrial processes. Atomization of Newtonian droplets is a well-studied area; however, non-Newtonian droplets have received less attention despite their being frequently encountered. By subjecting polymeric droplets of different concentrations to the induced airflow behind a moving shock wave, we explore the role of elasticity in modulating the aerobreakup of viscoelastic droplets. Three distinct modes of aerobreakup are identified for a wide range of Weber number

$({\sim }10^2\unicode{x2013}10^4)$

and elasticity number

$({\sim }10^{-4}\unicode{x2013}10^2)$

variation: these modes are vibrational, shear-induced entrainment and catastrophic breakup modes. Each mode is described as a three-stage process. Stage I is droplet deformation, stage II is the appearance and growth of hydrodynamic instabilities and stage III is the evolution of liquid mass morphology. It is observed that elasticity plays an insignificant role in the first two stages but a dominant role in the final stage. The results are described with the support of adequate mathematical analysis.
Bright or dark, vain or villainous? How entrepreneurial fitness, Machiavellianism and narcissism relate to entrepreneurial intention
Authors: Hanson Sheila K. , Valentine Sean R. , Shultz Patrick L.
Published: June 2023

This study investigates antecedents of entrepreneurial intentions of young adults, the next generation of entrepreneurs. We determine whether aspiring entrepreneurs' positive and dark traits relate to entrepreneurial intentions. Results indicated that entrepreneurial fitness, a second-order construct comprised of multiple positive and bright traits, positively relates to entrepreneurial intention, while the dark traits of Machiavellianism and narcissism differentially relate to entrepreneurial fitness and intention. Narcissism positively relates to entrepreneurial fitness and intention both directly and indirectly. Though Machiavellianism positively and directly relates to entrepreneurial intention, it also negatively and indirectly relates to intention through a negative relationship with entrepreneurial fitness. However, overall, entrepreneurial fitness positively relates with entrepreneurial intention. Findings extend the core model of entrepreneurial intention by concurrently illuminating the adaptive and maladaptive aspects of the dark side of narcissism and Machiavellianism with the bright, positive antecedents of entrepreneurial intention with entrepreneurial fitness. Theoretical and practical implications are discussed.
Selecting More Informative Training Sets with Fewer Observations
Authors: Kaufman Aaron R.
Published: June 2023

A standard text-as-data workflow in the social sciences involves identifying a set of documents to be labeled, selecting a random sample of them to label using research assistants, training a supervised learner to label the remaining documents, and validating that model’s performance using standard accuracy metrics. The most resource-intensive component of this is the hand-labeling: carefully reading documents, training research assistants, and paying human coders to label documents in duplicate or more. We show that hand-coding an algorithmically selected rather than a simple-random sample can improve model performance above baseline by as much as 50%, or reduce hand-coding costs by up to two-thirds, in applications predicting (1) U.S. executive-order significance and (2) financial sentiment on social media. We accompany this manuscript with open-source software to implement these tools, which we hope can make supervised learning cheaper and more accessible to researchers.
Impact assessment of heat stress during post-silking period of summer maize in the Huang-Huai-Hai Plain, China
Authors: Fu Zhenzhen , Liu Zhijuan , Guo Shibo , Zhang Zhentao , Lu Xiaomeng , Gong Jingjin , Dong Meiqi , Yang Xiaoguang
Published: June 2023

Arising of disasters by climate change had affected crop growth and yield, and then threaten local to global food security, particularly heat stress. Therefore, hazard assessment is essential to develop effective disaster risk management and adaptation interventions to ensure food security. In this study, the accumulated heat stress days (DAY), heat stress intensity (HSI) and heat degree-days (HDD) during the post-silking period of summer maize in The Huang-Huai-Hai Plain were investigated. Based on the optimal probability distribution function of HDD and information diffusion theory, we compute heat stress classification index and the possibility of heat stress, respectively. During 1981–2019, DAY, HSI and HDD were 11.8 d, 31.9°C and 23.6°Cd and increased by 0.67 d/decade, 0.10°C/decade and 3.14°Cd/decade, respectively. The threshold and hazard probability of mild, moderate and severe heat stress were 9.4, 19.4 and 34.2°Cd and 16.6, 9.3 and 4.5%, respectively. The heat stress hazard index (M) was 0.48, ranged from 0 to 0.77 during 1981 to 2019.Mwill increase in the future at all regions, particularly after 2060. Under SSP5-8.5 climate scenario,Mranged from 0.95 to 1.20 in 2080s, about two times than historical period. This could be used in optimizing agricultural management in summer maize production in order to combat heat stress under projected climate change.
How epistemic anxiety and curiosity link perceived value and intended efforts in the language classroom
Authors: Fraschini Nicola , Tao Yu
Published: June 2023

Language learner anxiety—and emotions in general—has constantly attracted academic attention in the second language acquisition (SLA) field for almost 40 years (Plonsky et al., 2022). However, within the context of the foreign language classroom, epistemic emotions remain understudied, despite their demonstrated effects on performance (D'Mello et al., 2014) and learners’ cognitive processes (Muis et al., 2018a). Epistemic emotions are academic emotions that “relate to knowledge-generating qualities of cognitive tasks and activities” (Pekrun et al., 2017, p. 1268). Their object focus lies in the generation of knowledge (Vogl et al., 2019a) and therefore are prominent during learning activities in academic settings. Recent research in SLA shows that epistemic emotions play a considerable role in instructed language learning (Fraschini, 2023; Nakamura et al., 2022). This current study analyses how two common epistemic emotions—epistemic anxiety and curiosity—mediate the link between a learner's perceived value and intended effort. Empirical data was collected using a tailor-designed survey administered to learners of Korean as a foreign language enrolled in a hybrid university course. Results show that epistemic anxiety and curiosity are independent of each other and coexist during language learning tasks. Furthermore, both epistemic emotions significantly correlate to a learner's perceived value of language learning, with opposite effects. While learners with a higher perceived value tend to be more curious, they also appear less anxious. These results are further discussed considering teachers’ and learners’ characteristics and in relation to theoretical and pedagogical implications for the language classroom.
“My Biggest Fear Is She’ll Die Alone”: Care Partner Perspectives of Institutional COVID-19 Visitor Restrictions in Ontario, Canada
Authors: Reid Julie C. , Carbone Sarah , Shaw Julia F. , Gallibois Molly , Hawkins Stacey A.
Published: June 2023

In March 2020, the Government of Ontario, Canada implemented public health measures, including visitor restrictions in institutional care settings, to protect vulnerable populations, including older adults (> 65 years), against COVID-19 infection. Prior research has shown that visitor restrictions can negatively influence older adults’ physical and mental health and can cause increased stress and anxiety for care partners. This study explores the experiences of care partners separated from the person they care for because of institutional visitor restrictions during the COVID-19 pandemic. We interviewed 14 care partners between the ages of 50 and 89; 11 were female. The main themes that emerged were changing public health and infection prevention and control policies, shifting care partner roles as a result of visitor restrictions, resident isolation and deterioration from the care partner perspective, communication challenges, and reflections on the impacts of visitor restrictions. Findings may be used to inform future health policy and system reforms.
Prediction of the onset of shear localization based on machine learning
Authors: Akar Samet , Aylı Ece , Ulucak Oğuzhan , Uğurer Doruk
Published: June 2023

Predicting the onset of shear localization is among the most challenging problems in machining. This phenomenon affects the process outputs, such as machining forces, surface quality, and machined part tolerances. To predict this phenomenon, analytical, experimental, and numerical methods (especially finite element analysis) are widely used. However, the limitations of each method hinder their industrial applications, demanding a reliable and time-saving approach to predict shear localization onset. Additionally, since this phenomenon largely depends on the type and parameters of the constitutive material model, any change in these parameters requires a new set of simulations, which puts further restrictions on the application of finite element modeling. This study aims to overcome the computational efficiency of the finite element method to predict the onset of shear localization when machining Ti6Al4V using machine learning methods. The obtained results demonstrate that the FCM (fuzzy c-means) clustering ANFIS (adaptive network-based fuzzy inference system) has given better results in both training and testing when it is compared to the ANN (artificial neural network) architecture with an R2 of 0.9981. Regarding this, the FCM-ANFIS is a good candidate to calculate the critical cutting speed. To the best of the authors’ knowledge, this is the first study in the literature that uses a machine learning tool to predict shear localization.
The Role of Exceptionalism in the Evolution of Bioethical Regulation
Authors: Shevchenko Sergei , Zhavoronkov Alexey
Published: June 2023

The paper aims to present a critical analysis of the phenomenon and notion of exceptionalism in bioethics. The authors demonstrate that exceptionalism pertains to phenomena that are not (yet) entirely familiar to us and could potentially bear risks regarding their regulation. After an overview of the state of the art, we briefly describe the origins and evolution of the concept, compared to exception and exclusion. In the second step, they look at the overall development debates on genetic exceptionalism, compared to other bioethical debates on exceptionalism, before presenting a detailed analysis of a specific case of early regulation of genetic screening. In the last part, the authors explain the historical background behind the connection between exceptionalism and exclusion in these debates. Their main conclusion is that while the initial stage of the discussion is shaped by the concept of exceptionalism and awareness of risks of exclusion, the later development centers around exceptions that are needed in detailed regulatory procedures.
Liquid storage of porcine in vitro-produced blastocysts; a practical approach for short storage
Authors: Haug Linda Marijke , Jochems Reina , Gaustad Ann Helen , Kommisrud Elisabeth , Myromslien Frøydis Deinboll , Grindflek Eli , Alm-Kristiansen Anne Hege
Published: June 2023

Commercial application of embryo transfer in pig breeding is dependent on the storage of embryos. The aim of this study was to assess the embryo quality of in vitro-produced blastocysts after 3 h liquid storage at 37°C in CO2-free medium by evaluating morphology, in vitro developmental capacity and apoptosis. Blastocysts at days 5 and 6 post-fertilization were randomly allocated to the storage group (HEPES-buffered NCSU-23 medium including bovine serum albumin in a portable embryo transport incubator at 37°C) or a control group (porcine blastocyst medium in a conventional culture incubator). Thereafter, blastocysts were evaluated for morphology and stained to assess apoptosis straight after the 3 h storage period or after a further 24 h conventional incubation. There was no significant difference between the storage and control group after 3 h storage and the further 24 h conventional incubation for any of the parameters, nor for apoptosis straight after the 3 h storage. Embryos that reached the blastocyst stage at day 5 showed less apoptosis (6.6% vs 10.9%, P = 0.01) and a trend for a higher rate of developmental capacity (70.6% vs 51.5%, P = 0.089) than embryos reaching the blastocyst stage on day 6. In conclusion, in vitro-produced porcine blastocysts can be stored for 3 h at physiological temperature in transportable incubators using a CO2-independent medium without compromising quality.
When English complement clauses meet evidential adverbs
Authors: KEMP LOIS
Published: June 2023

There is much literature about the licensing of complement clauses by complement-taking predicates. However, less has been written about the licensing of adverbs in a complement clause. This article addresses the licensing of English evidential adverbs in complement clauses extracted from the NOW corpus. The article discusses three factors that determine the distribution of evidential adverbs in complement clauses. These are the nature of the evidential adverbs, the constraints of the complement clause and the anchor of the evidential adverb. To explore the role of these three factors, I adopt the hierarchical scopal theory of Functional Discourse Grammar (FDG). If a complement clause licenses the inclusion of the evidential adverb, then there is a match. Should there be no alignment between the complement clause and the adverb, there will be a mismatch. The results of the analysis of the data show that there are mostly matches, which occur with either a current speaker anchor or an actor anchor. Secondly, it appears that in cases of mismatches, there is always a current speaker. It thus appears that a current speaker anchor can override the constraints of the complement clause.
Shirin Nezammafi and the unmaking of postcolonial Japan
Authors: Ghadimi Amin
Published: June 2023

This article takes up the short work of fiction Salam, written in Japanese in 2006 by Shirin Nezammafi, and deploys it as a primary source in the history of the Japanese present. Salam tells the tale of Layla, an Afghan migrant detained in and then expelled from Japan in 2001. The article argues that Salam exposes the unmaking of postcolonial Japan: if postcolonial Japan meant a territorial, sovereign nation-state built on hegemonic national myths, then now it is unsustainable. Salam calls to an inevitable if uncharted post-national, post-territorial future. To advance this argument, the article focuses on Nezammafi's treatment of three humanistic categories tied up with geopolitical territoriality: language, art, and gender. These categories, when associated with the nation-state, generate irony in Salam. That irony stems from the anachronism of nations: territorial nations, Japanese or otherwise, appear as past entities that have outlived their possibility.
Perceiving law without colonialism: Revisiting courts and constitutionalism in South Asia
Authors: Farid Cynthia
Published: June 2023

This article argues that the colonial government in India was shaped by changes in property law, race relations and other institutional interests that accompanied the political and economic restructuring of the colonial state. Therefore, the development of constitutionalism was the outcome of an interplay between institutional and professional interests and larger socio-economic and political forces. Against the backdrop of empire, constitutionalism in British India was defined by a specific form of allocation of powers between the executive (which also exercised legislative powers) and the high courts. The structure that developed as a result was a strong executive government, particularly in its exercise of power in local districts with formal judicial scrutiny introduced after 1861. The relationship between the executive and the judiciary in localities generated a series of conflicts and tensions, which were exacerbated by the expansion of the bureaucracy, the legal profession and gradual inclusion of Indians in the upper strata of governance. Taken together, these factors led to the development of a hybrid model of separation of powers in the Indian subcontinent, which seems to have stood the test of time in post-colonial countries of South Asia despite political elites having invested considerable resources on constitutional reform.
Monitoring Deep Sea Currents With Seafloor Distributed Acoustic Sensing
Authors: Mata Flores Daniel , Sladen Anthony , Ampuero Jean‐Paul , Mercerat E. Diego , Rivet Diane
Published: June 2023

Underwater fiber optic cables commonly traverse a variety of seafloor conditions, which leads to an uneven mechanical coupling between the cable and the ocean bottom. On rough seafloor bathymetry, some cable portions might be suspended and thus susceptible to vortex‐induced vibrations (VIV) driven by deep ocean currents. Here, we examine the potential of distributed acoustic sensing (DAS) to monitor deep‐sea currents along suspended sections of underwater telecom fiber optic cables undergoing VIV. Oscillations of a seafloor fiber optic cable located in southern France are recorded by DAS along cable sections presumably hanging. Their characteristic frequencies are lower than 1 Hz, at different ocean depths, and have an amplitude‐dependency consistent with the driving mechanism being VIV. Based on a theoretical proportionality between current speed and VIV frequencies, we derive ocean current speed time series at 2,390 m depth from the vortex shedding frequencies recorded by DAS. The DAS‐derived current speed time series is in agreement with recordings by a current meter located 3.75 km away from the hanging cable section (similar dominant period, high correlation after time shift). The DAS‐derived current speed time series displays features, such as characteristic periods and spectral decay, associated with the generation of internal gravity waves and weak oceanic turbulence in the Mediterranean Sea. The results demonstrate the potential of DAS along hanging segments of fiber optic cables to monitor a wide range of oceanography processes, at depths barely studied with current instrumentation.
Exploring the Influence of Summer Temperature on Human Mobility During the COVID‐19 Pandemic in the San Francisco Bay Area
Authors: Ly Amina , Davenport Frances V. , Diffenbaugh Noah S.
Published: June 2023

Studies on the relationship between temperature and local, small scale mobility are limited, and sensitive to the region and time period of interest. We contribute to the growing mobility literature through a detailed characterization of the observed temperature‐mobility relationship in the San Francisco Bay Area at fine spatial and temporal scale across two summers (2020–2021). We used anonymized cellphone data from SafeGraph's neighborhood patterns data set and gridded temperature data from gridMET, and analyzed the influence of incremental changes in temperature on mobility rate (i.e., visits per capita) using a panel regression with fixed effects. This strategy enabled us to control for spatial and temporal variability across the studied region. Our analysis suggested that all areas exhibited lower mobility rate in response to higher summer temperatures. We then explored how several additional variables altered these results. Extremely hot days resulted in faster mobility declines with increasing temperatures. Weekdays were often more resistant to temperature changes when compared to the weekend. In addition, the rate of decrease in mobility in response to high temperature was significantly greater among the wealthiest census block groups compared with the least wealthy. Further, the least mobile locations experienced significant differences in mobility response compared to the rest of the data set. Given the fundamental differences in the mobility response to temperature across most of our additive variables, our results are relevant for future mobility studies in the region.
The Deep‐Learning‐Based Fast Efficient Nighttime Retrieval of Thermodynamic Phase From Himawari‐8 AHI Measurements
Authors: Tong Xuan , Li Jingwei , Zhang Feng , Li Wenwen , Pan BaoXiang , Li Jun , Letu Husi
Published: June 2023

Retrieval of the cloud thermodynamic phase (CP) is essential for satellite remote sensing and downstream applications. However, there is still a lack of efficient nighttime CP data products. A transfer‐learning‐based deep learning model, transfer‐learning‐ResUnet, is proposed to retrieve the nighttime CP of Himawari‐8 from thermal infrared channels. Cloud products of Himawari‐8 and Moderate‐resolution Imaging Spectroradiometers were selected as labels during training. A benchmark obtained by the Cloud‐Aerosol Lidar and Infrared Pathfinder Satellite Observations confirmed the accuracy of the CP retrieval. During three independent months, the daytime and nighttime retrieval accuracy of the CP was 0.867 and 0.816, respectively, which was superior to that of the Himawari‐8 operational product in the daytime (0.788).
Implementation and Testing of Radar Data Assimilation Capabilities Within the Joint Effort for Data Assimilation Integration Framework With Ensemble Transformation Kalman Filter Coupled With FV3‐LAM Model
Authors: Park Jun , Xue Ming , Liu Chengsi
Published: June 2023

Capabilities to directly assimilate radar data are implemented within the local ensemble transform Kalman filter (LETKF) and the gain‐form LETKF (LGETKF) algorithms of the Joint Effort for Data assimilation Integration (JEDI) system. The capabilities are evaluated for the analysis and forecast of a severe convection case of 20 May 2019 in the Southern Great Plains using the limited area model version of the FV3 dynamical core (FV3‐LAM) from a recent release for Short‐Range Weather Application (SRW App). The LETKF and LGETKF implementations are shown to produce analyses and short‐range forecasts comparable to those using the ensemble square‐root Kalman Filter (EnSRF) within the Gridpoint Statistical Interpolation (GSI) framework used by current NCEP operational models. In addition, LGETKF retaining only 60% variances for model‐space vertical localization performs similarly to LGETKF retaining 99% of variance and LETKF using observation error‐based vertical localization. JEDI LETKF shows better parallel scalability than LGETKF and GSI EnSRF.