bluuebunny/crossref_metadata_2025 huggingface dataset:
Proteomic Analysis of KCNK3 Loss of Expression Identified Dysregulated Pathways in Pulmonary Vascular Cells
Authors: Le Ribeuz Hélène , Dumont Florent , Ruellou Guillaume , Lambert Mélanie , Balliau Thierry , Quatredeniers Marceau , Girerd Barbara , Cohen-Kaminsky Sylvia , Mercier Olaf , Yen-Nicolaÿ Stéphanie , Humbert Marc , Montani David , Capuano Véronique , Antigny Fabrice
Published: October 2020

The physiopathology of pulmonary arterial hypertension (PAH) is characterized by pulmonary artery smooth muscle cell (PASMC) and endothelial cell (PAEC) dysfunction, contributing to pulmonary arterial obstruction and PAH progression. KCNK3 loss of function mutations are responsible for the first channelopathy identified in PAH. Loss of KCNK3 function/expression is a hallmark of PAH. However, the molecular mechanisms involved in KCNK3 dysfunction are mostly unknown. To identify the pathological molecular mechanisms downstream of KCNK3 in human PASMCs (hPASMCs) and human PAECs (hPAECs), we used a Liquid Chromatography-Tandem Mass Spectrometry-based proteomic approach to identify the molecular pathways regulated by KCNK3. KCNK3 loss of expression was induced in control hPASMCs or hPAECs by specific siRNA targeting KCNK3. We found that the loss of KCNK3 expression in hPAECs and hPASMCs leads to 326 and 222 proteins differentially expressed, respectively. Among them, 53 proteins were common to hPAECs and hPASMCs. The specific proteome remodeling in hPAECs in absence of KCNK3 was mostly related to the activation of glycolysis, the superpathway of methionine degradation, and the mTOR signaling pathways, and to a reduction in EIF2 signaling pathways. In hPASMCs, we found an activation of the PI3K/AKT signaling pathways and a reduction in EIF2 signaling and the Purine Nucleotides De Novo Biosynthesis II and IL-8 signaling pathways. Common to hPAECs and hPASMCs, we found that the loss of KCNK3 expression leads to the activation of the NRF2-mediated oxidative stress response and a reduction in the interferon pathway. In the hPAECs and hPASMCs, we found an increased expression of HO-1 (heme oxygenase-1) and a decreased IFIT3 (interferon-induced proteins with tetratricopeptide repeats 3) (confirmed by Western blotting), allowing us to identify these axes to understand the consequences of KCNK3 dysfunction. Our experiments, based on the loss of KCNK3 expression by a specific siRNA strategy in control hPAECs and hPASMCs, allow us to identify differences in the activation of several signaling pathways, indicating the key role played by KCNK3 dysfunction in the development of PAH. Altogether, these results allow us to better understand the consequences of KCNK3 dysfunction and suggest that KCNK3 loss of expression acts in favor of the proliferation and migration of hPASMCs and promotes the metabolic shift and apoptosis resistance of hPAECs.
CX3CR1 Deficiency Attenuates DNFB-Induced Contact Hypersensitivity through Skewed Polarization towards M2 Phenotype in Macrophages
Authors: Otobe Sayaka , Hisamoto Teruyoshi , Miyagaki Tomomitsu , Morimura Sohshi , Suga Hiraku , Sugaya Makoto , Sato Shinichi
Published: October 2020

CX3CL1 can function as both an adhesion molecule and a chemokine for CX3CR1+ cells, such as T cells, monocytes, and NK cells. Recent studies have demonstrated that CX3CL1–CX3CR1 interaction is associated with the development of various inflammatory skin diseases. In this study, we examined CX3CR1 involvement in 2,4-dinitrofluorobenzene (DNFB)-induced contact hypersensitivity using CX3CR1−/− mice. Ear swelling and dermal edema were attenuated after DNFB challenge in CX3CR1−/− mice. Expression of TNF-α, IL-6, and M1 macrophage markers was decreased in the ears of CX3CR1−/− mice, whereas expression of M2 macrophage markers including arginase-1 was increased. Decreased TNF-α and IL-6 expression and increased arginase-1 expression were found in peritoneal macrophages from CX3CR1−/− mice. Furthermore, ear swelling was attenuated by depleting dermal macrophages in wild-type mice to a similar level to CX3CR1−/− mice. These results suggest that CX3CR1 deficiency could induce skewed polarization towards M2 phenotype in macrophages, resulting in attenuation of contact hypersensitivity response.
Leveraging Logistics Competence in New Product Sourcing: The Role of Strategic Intent and Impact on Performance
Authors: Kim Myung , Narasimhan Ram , Schoenherr Tobias
Published: October 2020

The purpose of the present research is to examine and compare product and logistics competencies in supplier selection decisions, which can serve as a crucial building block for competitive differentiation, in the context of the unique private label (PL) supply chain. This study also hypothesizes about the impact of product and logistics competence on the retailer’s financial performance. Lastly, the moderating role of the product type in the proposed research model is explored. Partial least squares path modelling is used to analyze the dataset drawn from major South Korean retailers, due to the exploratory nature of the research and the use of both reflective and formative construct measurement items. Overall, the results of this study demonstrate that relationships between the desire for a particular strategic intent and performance are more complex than previous studies have implied. The findings of this research offer possible explanations on an important but understudied aspect of PL success: why not all PLs (even of the same retailer) are thriving even in a rapidly growing PL industry. We further elicit strategic recommendations for retailers in selecting PL suppliers and for PL manufacturers to differentiate themselves and achieve a superior performance.
Topotactic Oxidation of Perovskites to Novel SrMo1-xMxO4−δ (M = Fe and Cr) Deficient Scheelite-Type Oxides
Authors: Cascos V. , Martínez-Coronado R. , Fernández-Díaz M. T. , Alonso J. A.
Published: October 2020

New polycrystalline SrMo1−xMxO4−δ (M = Fe and Cr) scheelite oxides have been prepared by topotactical oxidation, by annealing in air at 500 °C, from precursor perovskites with the stoichiometry SrMo1−xMxO3−δ (M = Fe and Cr). An excellent reversibility between the oxidized Sr(Mo,M)O4−δ scheelite and the reduced Sr(Mo,M)O3−δ perovskite phase accounts for the excellent behavior of the latter as anode material in solid-oxide fuel cells. A characterization by X-ray powder diffraction (XRD) and neutron powder diffraction (NPD) has been carried out to determine the crystal structure features. The scheelite oxides are tetragonal, space group I41/a (No. 88). The Rietveld-refinement from NPD data at room temperature shows evidence of oxygen vacancies in the structure, due to the introduction of Fe3+/Cr4+ cations in the tetrahedrally-coordinated B sublattice, where Mo is hexavalent. A thermal analysis of the reduced perovskite (SrMo1−xMxO3−δ) in oxidizing conditions confirms the oxygen stoichiometry obtained by NPD data; the stability range of the doped oxides, below 400–450 °C, is lower than that for the parent SrMoO3 oxide. The presence of a Mo4+/Mo5+ mixed valence in the reduced SrMo1−xMxO3−δ perovskite oxides confers greater instability against oxidation compared with the parent oxide. Finally, an XPS study confirms the surface oxidation states of Mo, Fe, and Cr in the oxidized samples SrMo0.9Fe0.1O4-δ and SrMo0.8Cr0.2O4-δ.
Structural and Chemical Hierarchy in Hydroxyapatite Coatings
Authors: Gross Karlis A. , Petzold Christiane , Pluduma-LaFarge Liene , Kumermanis Maris , Haugen Håvard J.
Published: October 2020

Hydroxyapatite coatings need similarly shaped splats as building blocks and then a homogeneous microstructure to unravel the structural and chemical hierarchy for more refined improvements to implant surfaces. Coatings were thermally sprayed with differently sized powders (20–40, 40–63 and 63–80 µm) to produce flattened homogeneous splats. The surface was characterized for splat shape by profilometry and Atomic force microscopy (AFM), crystal size by AFM, crystal orientation by X-ray diffraction (XRD) and structural variations by XRD. Chemical composition was assessed by phase analysis, but variations in chemistry were detected by XRD and Raman spectroscopy. The resulting surface electrical potential was measured by Kelvin probe AFM. Five levels of structural hierarchy were suggested: the coating, the splat, oriented crystals, alternate layers of oxyapatite and hydroxyapatite (HAp) and the suggested anion orientation. Chemical hierarchy was present over a lower range of order for smaller splats. Coatings made from smaller splats exhibited a greater electrical potential, inferred to arise from oxyapatite, and supplemented by ordered OH− ions in a rehydroxylated surface layer. A model has been proposed to show the influence of structural hierarchy on the electrical surface potential. Structural hierarchy is proposed as a means to further refine the properties of implant surfaces.
Numerical Considerations in the Modeling of a High Explosive Cylinder Experiment Using an ALE Continuum Mechanics Code
Authors: Zocher Marvin A. , Aslam Tariq D.
Published: October 2020

A series of experiments involving the detonation of PBX 9501 encased in a copper cylinder are modeled with the objective of evaluating a proposed set of phenomenological parameters for the Wescott–Stewart–Davis reactive burn model. The numerical analysis is conducted using the Los Alamos continuum mechanics code FLAG. Numerical considerations pertaining to various aspects of modeling the experiments using FLAG are discussed. It is shown that use of the proposed set of phenomenological parameters results in predictions of free-surface velocity that match empirically measured velocities reasonably well.
High Reserve in δ-Tocopherol of Peganum harmala Seeds Oil and Antifungal Activity of Oil against Ten Plant Pathogenic Fungi
Authors: Hajji Abdelhamid , Bnejdi Fethi , Saadoun Mourad , Ben Salem Ibtissem , Nehdi Imededdine , Sbihi Hassen , Alharthi Fahad A. , El Bok Safia , Boughalleb-M’Hamdi Naima
Published: October 2020

This investigation included the chemical analysis of Peganum harmala (P. harmala) seed oil and its antifungal properties against 10 fungal species. Seed oils of six populations were analyzed using high performance liquid chromatography (HPLC) and gas chromatograph/mass spectrometry (GC-MS). The HPLC analysis indicated that P. harmala seed oil exhibited a very high level of tocopherol contents, with values in the range of 2385.66–2722.68 mg/100 g. The most abundant tocopherol isomer was δ-tocopherol (90.39%), followed by γ-tocopherol (8.08%) and α-tocopherol (1.14%). We discovered for the first time the presence of tocotrenols in P. harmala seed oils of the six populations studied. The GC-MS analyses revealed that linoleic acid was the main fatty acid (65.17%), followed by oleic acid (23.12%), palmitic acid (5.36%) and stearic acid (3.08%). We also studied the antifungal activity of seed oil of the Medenine (MD) population on ten fungal pathogens. The antifungal effects differed among pathogens and depended on oil concentrations. Seed oil of the MD population caused a significant decrease in mycelial growth of all fungi tested, with values ranging 31.50–82.11%, except for Alternaria sp., which showed no inhibition. The antifungal activity against the 10 selected fungi can be explained by the richness in tocols of the extracted oil and make P. harmala a promising crop for biological control. Furthermore, the importance of fatty acids and the wide geographic spread in Tunisia of this species make this crop a potential source of renewable energy.
Anti-Hypertensive Effects of Peptides Derived from Rice Bran Protein
Authors: Shobako Naohisa , Ohinata Kousaku
Published: October 2020

Hypertension is one of the major risk factors for arteriosclerosis. Anti-hypertensive peptides derived from animal proteins, such as milk, eggs and fish, are well studied. Anti-hypertensive peptides have also been identified from plant proteins such as soybeans. Rice bran, a byproduct of white rice polishing, is rich in protein and its high protein efficiency ratio is well known. This review discusses the anti-hypertensive peptides identified from rice bran protein and their mechanisms. In addition, we describe protease-digested rice bran from which functional peptides have not been isolated.
Prevalent Seasoning and Cooking Fats, Arterial Stiffness and Blood Lipid Pattern in a Rural Population Sample: Data from the Brisighella Heart Study
Authors: Cicero Arrigo F.G. , Fogacci Federica , Grandi Elisa , Rizzoli Elisabetta , Bove Marilisa , D’Addato Sergio , Borghi Claudio
Published: October 2020

Background: Dietary fats have been variably associated with the risk of cardiovascular disease. The aim of our study was to evaluate the association between everyday mainly used dietary fats in cooking and as seasoning and hemodynamic and lipid parameters. Methods: For this study, we selected from the Brisighella Heart Study cohort subjects who were not treated with antihypertensive drugs and report with certainty their daily mean intake of dietary fats in cooking and as seasoning. Depending on the main source of dietary fat, the involved subjects were classified as prevalent extra-virgin olive oil (EVO) users, prevalent corn oil users, prevalent users of different vegetable oils and prevalent animal fat users, and we compared their characteristics. Results: Everyday consumption of EVO as a main seasoning and cooking fat source was significantly associated to lower body mass index, visceral adiposity index, blood pressure, arterial stiffness, and cholesterolemia, when compared with predominantly animal fat users. Corn oil users also had lower blood pressure, arterial stiffness, and cholesterolemia, when compared with predominantly animal fat users, as well. In particular, in an age and systolic blood pressure adjusted model, the predictors of carotid-femoral pulse wave velocity were the prevalent use of EVO (RR = 0.84, 95% CI 0.67–0.94 vs. other prevalent fat sources), LDL-Cholesterol (RR = 1.12, 95% CI 1.02–1.42), serum uric acid (RR = 1.21, 95% CI 1.09–1.54) and estimated GFR (RR = 0.77, 95% CI 0.59–0.99). Conclusions: According to our findings, the choice of everyday seasoning and cooking fat is associated with a different metabolic and haemodynamic pattern.
Overcoming Barriers for siRNA Therapeutics: From Bench to Bedside
Authors: Sajid Muhammad Imran , Moazzam Muhammad , Kato Shun , Yeseom Cho Kayley , Tiwari Rakesh Kumar
Published: October 2020

The RNA interference (RNAi) pathway possesses immense potential in silencing any gene in human cells. Small interfering RNA (siRNA) can efficiently trigger RNAi silencing of specific genes. FDA Approval of siRNA therapeutics in recent years garnered a new hope in siRNA therapeutics. However, their therapeutic use is limited by several challenges. siRNAs, being negatively charged, are membrane-impermeable and highly unstable in the systemic circulation. In this review, we have comprehensively discussed the extracellular barriers, including enzymatic degradation of siRNAs by serum endonucleases and RNAases, rapid renal clearance, membrane impermeability, and activation of the immune system. Besides, we have thoroughly described the intracellular barriers such as endosomal trap and off-target effects of siRNAs. Moreover, we have reported most of the strategies and techniques in overcoming these barriers, followed by critical comments in translating these molecules from bench to bedside.
Co-Delivery of Cisplatin and Gemcitabine via Viscous Nanoemulsion for Potential Synergistic Intravesical Chemotherapy
Authors: Chen Ting-Yu , Tsai Ming-Jun , Chang Li-Ching , Wu Pao-Chu
Published: October 2020

Combined chemotherapy is an effective and safe treatment for cancers. Co-administration of cisplatin and gemcitabine produces a synergistic effect for bladder cancer treatment, so viscous microemulsions were developed for co-delivery of cisplatin and gemcitabine to extend the retention time and improve the permeability of chemotherapeutic drugs into the urothelium by intravesical administration. Results showed that the deposition amounts of cisplatin and gemcitabine significantly increased in in vitro and in vivo study. The penetration depth in bladder tissue samples increased from 60 to 120 μm. The dual-loaded formulation also showed thermodynamic and chemical stability, demonstrating that these gel-based microemulsions are promising drug delivery carriers for chemotherapy agents by intravesical administration.
Nanoconfined Crosslinked Poly(ionic liquid)s with Unprecedented Selective Swelling Properties Obtained by Alkylation in Nanophase-Separated Poly(1-vinylimidazole)-l-poly(tetrahydrofuran) Conetworks
Authors: Stumphauser Tímea , Kasza György , Domján Attila , Wacha András , Varga Zoltán , Thomann Yi , Thomann Ralf , Pásztói Balázs , Trötschler Tobias M. , Kerscher Benjamin , Mülhaupt Rolf , Iván Béla
Published: October 2020

Despite the great interest in nanoconfined materials nowadays, nanocompartmentalized poly(ionic liquid)s (PILs) have been rarely investigated so far. Herein, we report on the successful alkylation of poly(1-vinylimidazole) with methyl iodide in bicontinuous nanophasic poly(1-vinylimidazole)-l-poly(tetrahydrofuran) (PVIm-l-PTHF) amphiphilic conetworks (APCNs) to obtain nanoconfined methylated PVImMe-l-PTHF poly(ionic liquid) conetworks (PIL-CNs). A high extent of alkylation (~95%) was achieved via a simple alkylation process with MeI at room temperature. This does not destroy the bicontinuous nanophasic morphology as proved by SAXS and AFM, and PIL-CNs with 15–20 nm d-spacing and poly(3-methyl-1-vinylimidazolium iodide) PIL nanophases with average domain sizes of 8.2–8.4 nm are formed. Unexpectedly, while the swelling capacity of the PIL-CN dramatically increases in aprotic polar solvents, such as DMF, NMP, and DMSO, reaching higher than 1000% superabsorbent swelling degrees, the equilibrium swelling degrees decrease in even highly polar protic (hydrophilic) solvents, like water and methanol. An unprecedented Gaussian-type relationship was found between the ratios of the swelling degrees versus the polarity index, indicating increased swelling for the nanoconfined PVImMe-l-PTHF PIL-CNs in solvents with a polarity index between ~6 and 9.5. In addition to the nanoconfined structural features, the unique selective superabsorbent swelling behavior of the PIL-CNs can also be utilized in various application fields.
Novel Copper Photoredox Catalysts for Polymerization: An In Situ Synthesis of Metal Nanoparticles
Authors: Tar Haja , Kashar Tahani I. , Kouki Noura , Aldawas Reema , Graff Bernadette , Lalevée Jacques
Published: October 2020

The copper II complex (HLCuCl) carrying 2,4 dinitrophenylhydrazone (L) is synthesized and evaluated as a new photoredox catalyst/photoinitiator in combination with triethylamine (TEA) and iodonium salt (Iod) for the radical polymerization of ethylene glycol diacrylate during exposure to visible light using a photoreactor at 419 nm. The copper complex reactivity with TEA/Iod salt/gold chloride showed a good production and stability of gold nanoparticles. Finally, the high performance of Cu (II) complex for radical photopolymerization incorporating gold nanoparticles is provided. The photochemical mechanisms for the production of initiating radicals are studied using cyclic voltammetry. Polymer nanocomposites containing gold nanoparticles (Au NPs) in situ photogenerated during the irradiation process were prepared. The formation of Au NPs inside the polymer matrix was through UV–Vis and EDS/SEM analyses.
The Energy and Carbon Footprint of an Urban Waste Collection Fleet: A Case Study in Central Italy
Authors: Quintili Alessio , Castellani Beatrice
Published: October 2020

Municipal solid waste collection and transport are functional activities in waste management, with a significant energy and carbon footprint and a significant effect on the urban environment. An issue related to municipal solid waste collection and transport is their regional and municipal implementation, affected by sorting and recycling strategies at local level. An efficient collection is necessary to optimize the whole recycling process. The present paper shows the results of an energy, environmental, and economic evaluation of a case study, analyzing the fleet used for municipal solid waste collection and transport in 10 municipalities in Central Italy. The current scenario was compared with alternative scenarios on the basis of some parameters for performance evaluation: vehicles’ energy consumption, carbon footprint, routes, and costs. Results show that for passenger cars, the alternative scenario based on an entire fleet of dual compressed natural gas (CNG) vehicles led to a reduction of the CO2 emissions (−2675 kgCO2eq) in the analyzed period (January–August 2019) and a reduction of the energy consumption (−1.96 MJ km−1). An entire fleet of CNG vehicles led to an increase of CO2 emissions: +0.02 kgCO2eqkgwaste−1 (+110%) for compactors (35–75 q) and +0.09 kgCO2eqkgwaste−1 (+377%) for compactors (80–180 q). Moreover, both categories report a higher fuel consumption and specific energy consumption. For waste transport high-capacity vehicles, we propose the installation of a Stop-Start System, which leads to environmental and energy benefits (a saving of 38,332 kgCO2eq and 8.8 × 10−7 MJ km−1kgwaste−1). On three-wheeler vehicles, the installation of the Stop-Start System is completely disadvantageous.
Identification of Polycentric Cities in China Based on NPP-VIIRS Nighttime Light Data
Authors: Ma Mingguo , Lang Qin , Yang Hong , Shi Kaifang , Ge Wei
Published: October 2020

Nighttime light data play an important role in the research on cities, while the urban centers over a large spatial scale are still far from clearly understood. Aiming at the current challenges in monitoring the spatial structure of cities using nighttime light data, this paper proposes a new method for identifying urban centers for massive cities at the large spatial scale based on the brightness information captured by the Suomi National Polar-Orbiting Partnership’s Visible Infrared Imaging Radiometer Suite (NPP-VIIRS) sensor. Based on the method for extracting the peak point based on digital elevation model (DEM) data in terrain analysis, the maximum neighborhood and difference algorithms were applied to the NPP-VIIRS data to extract the pixels with the peak nighttime light intensity to identify the potential locations of urban centers. The results show 7239 urban centers in 2200 cities in China in 2017, with an average of 3.3 urban centers per city. Approximately 68% of the cities had significant polycentric structures. The developed method in this paper is useful for identifying the urban centers and can provide the reference to the city planning and construction.
A Priority Data Association Policy for Multitarget Tracking on Intelligent Vehicle Risk Assessment
Authors: Zeng Dequan , Xiong Lu , Yu Zhuoping , Chen Qiping , Fu Zhiqiang , Li Zhuoren , Zhang Peizhi , Xu Puhang , Qian Zixuan , Xiao Hongyu , Fang Peiyuan , Li Zhiqiang , Leng Bo
Published: October 2020

In order to conduct risk assessment for collision-free decision making of intelligent vehicles in a complex road traffic environment, it is essential to conduct stable tracking and state estimation of multiple vehicle targets. Therefore, this paper proposes a multitarget tracking method in line with the priority data association rule. Firstly, a standard coordinate turn process model is deduced as the existence of translation and rotation of the vehicle on the two-dimensional ground plane. Secondly, an unscented Kalman filter algorithm is developed due to the nonlinear radar measurement model. Thirdly, a priority data association rule, which puts the targets in a priority queue according to the number of times they are associated, is designed to filter out noise, given that it is unlikely for a vehicle target as an inertial system to appear or disappear instantly in practice. In addition, the data association rule specifies that the closer the target is to the front of the queue, the more prioritized the association with the newly observed target would be. Finally, the track management algorithm is constructed. On this basis, a series of real vehicle tests were conducted on real roads with four typical scenarios. According to the test results, the proposed algorithm is effective in filtering out noise and is suboptimal as the nearest neighbor data association.
A Review of Measurement Calibration and Interpretation for Seepage Monitoring by Optical Fiber Distributed Temperature Sensors
Authors: Ghafoori Yaser , Vidmar Andrej , Říha Jaromír , Kryžanowski Andrej
Published: October 2020

Seepage flow through embankment dams and their sub-base is a crucial safety concern that can initiate internal erosion of the structure. The thermometric method of seepage monitoring employs the study of heat transfer characteristics in the soils, as the temperature distribution in earth-filled structures can be influenced by the presence of seepage. Thus, continuous temperature measurements can allow detection of seepage flows. With the recent advances in optical fiber temperature sensor technology, accurate and fast temperature measurements, with relatively high spatial resolution, have been made possible using optical fiber distributed temperature sensors (DTSs). As with any sensor system, to obtain a precise temperature, the DTS measurements need to be calibrated. DTS systems automatically calibrate the measurements using an internal thermometer and reference section. Additionally, manual calibration techniques have been developed which are discussed in this paper. The temperature data do not provide any direct information about the seepage, and this requires further processing and analysis. Several methods have been developed to interpret the temperature data for the localization of the seepage and in some cases to estimate the seepage quantity. An efficient DTS application in seepage monitoring strongly depends on the following factors: installation approach, calibration technique, along with temperature data interpretation and post-processing. This paper reviews the different techniques for calibration of DTS measurements as well as the methods of interpretation of the temperature data.
GNSS-Based Non-Negative Absolute Ionosphere Total Electron Content, its Spatial Gradients, Time Derivatives and Differential Code Biases: Bounded-Variable Least-Squares and Taylor Series
Authors: Yasyukevich Yury , Mylnikova Anna , Vesnin Artem
Published: October 2020

Global navigation satellite systems (GNSS) allow estimating total electron content (TEC). However, it is still a problem to calculate absolute ionosphere parameters from GNSS data: negative TEC values could appear, and most of existing algorithms does not enable to estimate TEC spatial gradients and TEC time derivatives. We developed an algorithm to recover the absolute non-negative vertical and slant TEC, its derivatives and its gradients, as well as the GNSS equipment differential code biases (DCBs) by using the Taylor series expansion and bounded-variable least-squares. We termed this algorithm TuRBOTEC. Bounded-variable least-squares fitting ensures non-negative values of both slant TEC and vertical TEC. The second order Taylor series expansion could provide a relevant TEC spatial gradients and TEC time derivatives. The technique validation was performed by using independent experimental data over 2014 and the IRI-2012 and IRI-plas models. As a TEC source we used Madrigal maps, CODE (the Center for Orbit Determination in Europe) global ionosphere maps (GIM), the IONOLAB software, and the SEEMALA-TEC software developed by Dr. Seemala. For the Asian mid-latitudes TuRBOTEC results agree with the GIM and IONOLAB data (root-mean-square was < 3 TECU), but they disagree with the SEEMALA-TEC and Madrigal data (root-mean-square was >10 TECU). About 9% of vertical TECs from the TuRBOTEC estimates exceed (by more than 1 TECU) those from the same algorithm but without constraints. The analysis of TEC spatial gradients showed that as far as 10–15° on latitude, TEC estimation error exceeds 10 TECU. Longitudinal gradients produce smaller error for the same distance. Experimental GLObal Navigation Satellite System (GLONASS) DCB from TuRBOTEC and CODE peaked 15 TECU difference, while GPS DCB agrees. Slant TEC series indicate that the TuRBOTEC data for GLONASS are physically more plausible.
Multibeam Characteristics of a Negative Refractive Index Shaped Lens
Authors: Hamid Salbiah Ab , Rahman Nurul Huda Abd , Yamada Yoshihide , Hung Phan Van , Quoc Dinh Nguyen
Published: October 2020

Narrow beam width, higher gain and multibeam characteristics are demanded in 5G technology. Array antennas that are utilized in the existing mobile base stations have many drawbacks when operating at upper 5G frequency bands. For example, due to the high frequency operation, the antenna elements become smaller and thus, in order to provide higher gain, more antenna elements and arrays are required, which will cause the feeding network design to be more complex. The lens antenna is one of the potential candidates to replace the current structure in mobile base station. Therefore, a negative refractive index shaped lens is proposed to provide high gain and narrow beamwidth using energy conservation and Abbe’s sine principle. The aim of this study is to investigate the multibeam characteristics of a negative refractive index shaped lens in mobile base station applications. In this paper, the feed positions for the multibeam are selected on the circle from the center of the lens and the accuracy of the feed position is validated through Electromagnetic (EM) simulation. Based on the analysis performed in this study, a negative refractive index shaped lens with a smaller radius and slender lens than the conventional lens is designed, with the additional capability of performing wide-angle beam scanning.
Detection of Small Magnetic Fields Using Serial Magnetic Tunnel Junctions with Various Geometrical Characteristics
Authors: Jin Zhenhu , Wang Yupeng , Fujiwara Kosuke , Oogane Mikihiko , Ando Yasuo
Published: October 2020

Thanks to their high magnetoresistance and integration capability, magnetic tunnel junction-based magnetoresistive sensors are widely utilized to detect weak, low-frequency magnetic fields in a variety of applications. The low detectivity of MTJs is necessary to obtain a high signal-to-noise ratio when detecting small variations in magnetic fields. We fabricated serial MTJ-based sensors with various junction area and free-layer electrode aspect ratios. Our investigation showed that their sensitivity and noise power are affected by the MTJ geometry due to the variation in the magnetic shape anisotropy. Their MR curves demonstrated a decrease in sensitivity with an increase in the aspect ratio of the free-layer electrode, and their noise properties showed that MTJs with larger junction areas exhibit lower noise spectral density in the low-frequency region. All of the sensors were able detect a small AC magnetic field (Hrms = 0.3 Oe at 23 Hz). Among the MTJ sensors we examined, the sensor with a square-free layer and large junction area exhibited a high signal-to-noise ratio (4792 ± 646). These results suggest that MTJ geometrical characteristics play a critical role in enhancing the detectivity of MTJ-based sensors.
Community-Driven Tourism Projects’ Economic Contribution to Community Livelihoods—A Case of Makuleke Contractual Park Community Tourism Project
Authors: Matiku Susan , Zuwarimwe Jethro , Tshipala Ndivhuwo
Published: October 2020

Tourism is a known rural economic development tool. Furthermore, sustainable tourism seeks to enhance the quality of the resident lives through its economic benefits, among others. One way of diversification economic bases in rural areas is through community-driven tourism projects (CDTP). The tourism projects provide a livelihood strategy to the communities who are involved in the projects. This study makes an attempt to build an understanding of the economic contribution of community-driven tourism projects to sustainable livelihoods. The study draws on a qualitative survey carried out in South Africa’s Makuleke contractual Park Community Project. The study utilized the community capital framework (CCF) to examine the community tourism economic capitals’ (CTEC) contribution to the community livelihoods. The study also investigated on the ripple effect of the economic capital towards other capitals within the community. Thematic content analysis was used to analyze qualitative data while descriptive statistics were used to analyze the demographic data. Findings indicate that through the Makuleke Contractual Park (MCP) tourism project, the community benefited economically in terms of employment and creation of small & medium tourism related enterprises which provided a livelihood strategy for the community. Through the projects’ partnerships with private investors, there was a ripple effect from the economic capital contribution to other community capitals (physical, human, social and natural). Community-driven tourism projects (CDTP) if well managed can transform community capital resources to economic multipliers which can be a livelihood strategy for the community.
Estimation of the Non-Greenhouse Gas Emissions Inventory from Ships in the Port of Incheon
Authors: Lee Hyangsook , Park Dongjoo , Choo Sangho , Pham Hoang T.
Published: October 2020

Nowadays, maritime air pollution is regarded as a severe threat to coastal communities’ health. Therefore, many policies to reduce air pollution have been established worldwide. Moreover, there has been a shift in policy and research attention from greenhouse gases, especially CO2, to other air pollutants. To address the current local environmental challenges, this research analyzes the non-greenhouse gas emissions inventory (CO, NOx, SOx, PM, VOC, and NH3) from ships in the second biggest port in Korea, the Port of Incheon (POI). A bottom-up activity-based methodology with real-time vessel activity data produced by the Vessel Traffic Service (VTS) is applied to obtain reliable estimations. NOx and SOx dominated the amount of emission emitted from ships. Tankers, general cargo ships, cruise ships, and container ships were identified as the highest sources of pollution. Based on the above results, this study discusses the need for long-term policies, such as the designation of a local emission control area (ECA) and the establishment of an emission management platform to reduce ship-source emissions. Furthermore, this study elucidates that significant emissions come from the docking process, ranging from 33.9% to 42.0% depending on the type of pollutant when only the auxiliary engines were being operated. Therefore, short-term solutions like applying exhausted gas cleaning systems, using on-shore power supplies, reducing docking time, or using greener alternative fuels (e.g., liquefied natural gas or biofuels) should be applied and motivated at the POI. These timely results could be useful for air quality management decision-making processes for local port operators and public agencies.
Effect of Biochar on Soil Temperature under High Soil Surface Temperature in Coal Mined Arid and Semiarid Regions
Authors: Xiong Jibing , Yu Runhua , Islam Ejazul , Zhu Fuhai , Zha Jianfeng , Sohail Muhammad Irfan
Published: October 2020

High soil surface temperature and loosened soil are major limiting factors of plant productivity in arid and semi-arid coal mining areas of China. Moreover, the extensive and illegitimate burning of crop residues is causing environmental pollution; whereas, these residues could be converted to biochar to benefit soil quality. In this study, the effect of wheat straw biochar (WSB) at rates of 0% (control, CK), 1% (low, LB), 2% (medium, MB) and 4% (high, HB) on soil temperature at different depths (5, 10, 15, and 20 cm) and moisture levels (10 and 20%) was investigated under high soil surface temperature of 50 °C and air humidity of 40%. Our data suggested that soil bulk density was inversely, and soil moisture was directly corelated with soil thermal parameters. Moreover, the increasing rate of WSB addition linearly decreased the soil thermal properties. The maximum decrease in soil bulk density at both moisture levels (10% and 20%) was measured in HB treatment compared to respective CKs. The highest decrease in soil thermal conductivity (59.8% and 24.7%) was found under HB treatment in comparison to respective controls (CK10% and CK20% moisture). The soil volumetric heat capacity was also strongly corelated with soil moisture content (r = 0.91). The WSB treatments displayed differential responses to soil temperature. Under 10% soil moisture, temperature of LB, MB and HB treatments was higher as compared to CK at 5–20 cm depth, and MB treated soil had the smallest increase in temperature. At the 15-cm depth, the MB treatment decreased the temperature by 0.93 °C as compared to the CK20%. Therefore, the effect of WSB on soil temperature was influenced by soil moisture content, soil depth and WSB application rates. It suggested that MB treatment could be a useful farming practice for mitigating soil temperature fluctuation.
Does High-Speed Rail Network Access Enhance Cities’ Innovation Performance?
Authors: Du Qunyang , Yu Hangdong , Yan Cheng , Yang Tianle
Published: October 2020

This study investigates the impacts of access to high-speed railway networks (HSRN) on urban innovative performance using a difference-in-difference method and a unique dataset including patents, nighttime lights, and HSRN at the city-level in China. First, access to HSRN significantly and positively affects the city’s innovative performance. Results remain robust after substituting different innovation indicators and controlling for city-level factors. Second, the impacts vary with the size of cities. Specifically, the benefits of access to HSRN for large and small cities are greater than for medium-sized cities, which shows a quasi-U-shaped relationship. Third, the positive effects of access to HSRN on innovation performance are stronger in knowledge-intensive industries for large cities and where there is high population mobility among cities.
Making Use of Evaluations to Support a Transition towards a More Sustainable Energy System and Society—An Assessment of Current and Potential Use among Swedish State Agencies
Authors: Sandin Sofie
Published: October 2020

Evaluations hold the potential to support decision-making so that current global challenges related to climate and energy can be addressed; however, as the challenges are becoming increasingly large and complex, new and transformative evaluation approaches are called for. Such transformative evaluation in turn builds on an extended and more deliberate use of evaluations. This study focuses on the current evaluation use practices among Swedish state agencies who are commissioning and/or conducting evaluations within climate and energy-related areas. Building on focus group sessions with four agencies and a structured interview questionnaire answered by representatives at five state agencies, the results shed light on how informants perceive the current practices of using evaluations, following the models of use presented in the evaluation literature. These results show perceived use as mainly instrumental or conceptual, along with showing an overall emphasis on models of use that are deemed constructive for moving towards transformative evaluations. The results also outline key benefits and challenges related to the adoption of a transformative evaluation approach. Such benefits include a more structured planning and use of evaluations, while challenges relate to institutional barriers and mandates to coordinate evaluations on a transformative scale.
Strategy for Well-Being in Universities: A Romanian Higher Education Approach
Authors: Iordache-Platis Magdalena
Published: October 2020

Student services represent one of the most important areas that has developed in every higher education institution and continues to evolve based on the students’ feedback and contextual issues. All quality assurance systems for higher education include standards to evaluate institutional capacity to provide these services. Well-being is one type of student service that universities have high interest in developing. In the current pandemic situation, significant changes towards digitalization have occurred, but at the same time, new types of student services based on counselling proved to be the most needed. Academic leadership is facing a lot of pressure to increase research visibility and deal with limited resources; therefore, a decision on well-being development is not easy. The purpose of this study is to reveal the well-being concept and practice as applied in different universities in Romania in order to build a possible institutional strategy (an introductory model). Apart from a literature review, conceptual clarifications, and best practices, the methodology includes a gap analysis and a survey based on a questionnaire to determine the students’ perceptions on the development of well-being services. The findings show the highest interest of respondents in contributing to the well-being service development. The conclusions indicate concrete steps for the establishment of a well-being strategy.
Investigating the Theoretical Constructs of a Green Lean Six Sigma Approach towards Environmental Sustainability: A Systematic Literature Review and Future Directions
Authors: Farrukh Amna , Mathrani Sanjay , Taskin Nazim
Published: October 2020

Green lean six sigma (GLSS) is an emerging approach towards environmental sustainability in conjunction with operational achievements. The success of this approach is premised on an understanding of the different components of a GLSS program; being the determinants for its outcomes. The aim of this paper is to investigate the various constructs of GLSS that play an essential role in achieving environmental sustainability. For this purpose, a systematic review of available literature has been conducted to evaluate the drivers, enablers (tools), and outcomes of a GLSS strategy as well as its critical success factors and barriers. Findings reveal that these constructs of GLSS as a holistic approach can facilitate an organization to better accomplish environmental objectives such as waste minimization, emission reduction, and resource conservation as compared to constructs of only one or any two of these strategies. Based on the analysis, an integrated GLSS framework is developed for environmental sustainability in addition to identifying vital research gaps and future directions.
Decarbonization Tradeoffs: A Dynamic General Equilibrium Modeling Analysis for the Chilean Power Sector
Authors: Nasirov Shahriyar , O’Ryan Raúl , Osorio Héctor
Published: October 2020

Medium size developing countries like Chile that commit to decarbonization goals need to carefully assess the trade-offs associated to their intensity and timing, since most of the technologies required will be absorbed, not produced, by these countries. A rapid expansion of renewables in the Chilean energy matrix, mostly thanks to exceptional solar and wind resources, combined with a rapid decrease in the cost of renewable energy technologies, intensified current policy debates to reduce the role of coal, which is the largest source of CO2 emissions in the generation mix. Recently, the main generation companies in Chile made a voluntary commitment to not invest in new coal projects that do not include carbon capture and storage systems. In addition, the Chilean government announced its plans to phase out coal plants completely by 2040. In this context, the aim of this research is to study the economy-wide and emission reduction impacts of different decarbonization paths in the Chilean power sector. For this purpose, we consider dynamic simulations using a new energy-oriented version of the Computable General Equilibrium Model (CGE)- General Equilibrium Model for the Chilean Economy (ECOGEM)-Chile which is soft linked to the bottom-up engineering energy model. The results show the major impacts under both the business as usual (BAU) scenario and the coal phase-out scenario. Additionally, the study discusses to what extent the ambitious decarbonization goals of the Chilean government are coherent with the current technological limitations.
An Ecosystem Services Valuation Research Framework for Policy Integration in Developing Countries: A Case Study from Nepal
Authors: Acharya Ram Prasad , Maraseni Tek Narayan , Cockfield Geoff
Published: October 2020

Forest ecosystem services (ES) valuation research has increased exponentially in recent years, and scholars accept that such research could be useful in reshaping governments’ policies. Despite such scholarly efforts, the research outcomes have had limited application in actual policies and plans. This study explores reasons why ES valuation research recommendations are not reflected in policy processes and proposes a research framework which, when appropriately applied, would lead to the adoption of research findings. Literature review, semi-structured expert interviews (N = 29), and a workshop (N = 2), were used to achieve these objectives. Experts expressed that limited stakeholder engagement is the key factor hindering incorporation of ES research outcomes in policies and plans. We developed a framework that comprises four major components (inputs, actors, outcomes, impacts) and sets out the seven major steps involved in implementing this framework. Effective engagement of relevant stakeholders in each step is critical to integrate the ES research outcomes in policy and plans although this will demand a lengthy timeframe and a high investment requirement. Such engagement would create an environment of trust that enhances the acceptability of research outcomes among stakeholders. The acceptability of the research outcomes can increase ownership leading to more informed decision making, and ultimately yield desired outcomes in ES conservation.
Review of Wave Energy Converter and Design of Mooring System
Authors: Qiao Dongsheng , Haider Rizwan , Yan Jun , Ning Dezhi , Li Binbin
Published: October 2020

In recent decades, the emphasis on renewable resources has grown considerably, leading to significant advances in the sector of wave energy. Nevertheless, the market cannot still be considered as commercialized, as there are still other obstacles in the mooring system for wave energy converters (WECs). The mooring system must be designed to not negatively impact the WEC’s efficiency and reduce the mooring loads. Firstly, the overview of the types of wave energy converters (WECs) are classified through operational principle, absorbing wave direction, location, and power take-off, respectively, and the power production analysis and design challenges of WECs are summarized. Then, the mooring materials, configurations, requirements, and the modeling approaches for WECs are introduced. Finally, the design of mooring systems, including the design considerations and standards, analysis models, software, current research focus, and challenges are discussed.
MPN Drop Agar Method for Determination of Heterotrophic Microorganisms in Soil and Water Samples Using Tissue Plate as a Carrier
Authors: Chumchalová Jana , Kubal Martin
Published: October 2020

The most probable number (MPN) method is a culture-based method commonly used in the field of environmental microbiology to examine microbial populations in liquid substrates. The MPN tests require a wide range of special laboratory equipment, a lot of laboratory space, and skilled staff, which together limit their applicability. This paper presents a modified MPN method, which reduces the experimental requirements by applying tissue plate as a carrier. The modified MPN method introduces a fast-filled tissue plate with 5 × 5 squares as agar carrier, instead of the commonly used set of glass tubes. Further, self-refilling automatic syringe Socorex® was implemented to apply samples to the plate. The response of the modified MPN method was tested on eight selected bacterial strains as well as on soil and water samples. Simultaneously, all the strains and samples were tested by standard spread plate method. High linear correlation between the two methods was found, which makes a new modified MPN method a useful alternative within the field of environmental microbiology.