bluuebunny/crossref_metadata_2025 huggingface dataset:
Pressure‐Induced Effects on BaPbO3: A Prospectively Valuable Material for Piezoelectric Applications via DFT
Authors: Alathlawi Hussain J. , Tariq Saad , Al‐Dossari Mawaheb , Mubarak A. A. , Saleem Muhammad , Saad H‐E M. Musa , Ali Mohsin , Kanwal Bushra
Published: April 2024

Employing density functional theory within the Wien2k code, first‐principle calculations are conducted to explore the impact of applied pressure up to 80 GPa on the structural, mechanical, thermal, and electronic characteristics of BaPbO3. Demonstrating metallic behavior with ductile attributes, BaPbO3 exhibits a decreasing anisotropic nature under escalating pressure. Evaluation of cubic elastic constants, optimization curves, and enthalpy of formation indicates the compound's mechanical and thermodynamic stability under high pressure conditions. Calculated values of C11 and C44 reflect heightened resistance to unidirectional compression and increased stiffness under pressure. These mechanical properties position BaPbO3 as a promising candidate for diverse industrial applications across varying pressure ranges, including utilization in piezoelectric materials (0–20 GPa) and high‐pressure sensors. Additionally, charge density contours suggest a combination of ionic (Ba─Pb) and covalent bonding (Pb─O) within the compound's constituent atoms. The material can exhibit potential applications as a piezoelectric sensor at 0–20 GPa, high‐pressure actuators ≈20 GPa, and as a high melting temperature resistive substrate for laser welding and cutting materials.
Mist Chemical Vapor Deposition Using Poorly Soluble Particles as Raw Material
Authors: Yamazaki Yuki , Nakamura Tsubasa , Kato Kodai , Hara Kazuhiko , Kouno Tetsuya
Published: April 2024

Mist chemical vapor deposition (mist‐CVD) is expected to be a potentially low‐environment‐impact and low‐cost crystal growth technique. With mist‐CVD, soluble materials are usually selected as raw materials, and mist is usually generated from an aqueous solution including raw materials. However, any substances to be included in the mist can be potentially supplied as raw materials. Namely, there is no need for the substances to be dissolved in some solvent. Therefore, as a trial, it is demonstrated that mist including poorly soluble particles are used as raw materials for mist‐CVD crystal growth.
Higher levels of virulence to multiple resistance genes were detected in Hessian fly (Mayetiola destructor) populations from Texas
Authors: Melson Ellen E. , Chen Ming‐Shun , Ibrahim Amir M. H. , Drake David, R. , Liu Shuyu , Sutton Russell , Zhu‐Salzman Keyan , Mays D. Tyler
Published: April 2024

Hessian fly is an important pest of wheat worldwide and is of particular importance in Texas and the southeastern United States. Texas is the highest wheat‐producing state that is severely impacted by this insect. The most effective control in these areas is an integrated pest management program, including resistant varieties of wheat. Hessian fly populations are genetically diverse and can rapidly become virulent to specific resistance genes once they are widely deployed in a region. Knowing the current virulence status of regional fly populations is important for wheat breeders and producers. In this study, a virulence analysis was conducted on populations sampled in the northeastern and central Texas regions. This analysis showed that resistance genes H12, H13, H20, H22, H25, H26, H28, H29, H32, H33, H34, and Hdic are still highly effective in these regions. However, it is also evident that Texas fly populations have become more virulent to existing genes in the past 10 years, with very high levels of virulence to resistance genes H3, H5, vH6, H7/H8, H9, H10, H14, H15, H23, H24, H31, and H35/H36.
2D TiO2 Nanosheets Decorated Via Sphere‐Like BiVO4: A Promising Non‐Toxic Material for Liquid Phase Photocatalysis and Bacterial Eradication
Authors: Hanif Muhammad Bilal , Bacova Jana , Berezenko Viktoriia , Zeng Yilan , Paluch Emil , Seniuk Alicja , Khan Muhammad Zubair , Rauf Sajid , Hussain Iftikhar , Motlochova Monika , Plesch Gustav , Monfort Olivier , Capek Jan , Dworniczek Ewa , Rousar Tomas , Motola Martin
Published: April 2024

An in‐depth investigation was conducted on a promising composite material (BiVO4/TiO2), focusing on its potential toxicity, photoinduced catalytic properties, as well as its antibiofilm and antimicrobial functionalities. The preparation process involved the synthesis of 2D TiO2 using the lyophilization method, which was subsequently functionalized with sphere‐like BiVO4 through wet impregnation. Finally, we developed BiVO4/TiO2 S‐scheme heterojunctions which can greatly promote the separation of electron‐hole pairs to achieve high photocatalytic performance. The evaluation of concentration‐ and time‐dependent viability inhibition was performed on human lung carcinoma epithelial A549 cells. This assessment included the estimation of glutathione levels and mitochondrial dehydrogenase activity. Significantly, the BiVO4/TiO2 composite demonstrated minimal toxicity towards A549 cells. Impressively, the BiVO4/TiO2 composite exhibited notable photocatalytic performance in the degradation of rhodamine B (k=0.135 min−1) and phenol (k=0.016 min−1). In terms of photoinduced antimicrobial performance, the composite effectively inactivated both gram‐negative E. coli and gram‐positive E. faecalis bacteria upon 60 minutes of UV‐A light exposure, resulting in a significant log 6 (log 10 CFU/mL) reduction in bacterial count. In addition, a 49 % reduction of E. faecalis biofilm was observed. These promising results can be attributed to the unique 2D morphology of TiO2 modified by sphere‐like BiVO4, leading to an increased generation of (intracellular) hydroxyl radicals, which plays a crucial role in the treatments of both organic pollutants and bacteria. This research has significant potential for various applications, particularly in addressing environmental contamination and microbial infections.
Small amplitude solitary electron acoustic wave for hot electrons taking regularized kappa distribution
Authors: Liu Yong , Wang Meng–Lei
Published: April 2024

The properties of small‐amplitude solitary electron acoustic waves in a plasma where the hot electrons take regularized kappa distribution are investigated via the reductive perturbation method. It is found there only exists the sup‐electron‐acoustic rarefactive soliton, the electron acoustic velocity is modified by the regularized kappa distribution. The amplitude and width of the electron acoustic soliton decrease monotonously with the increase of the exponential cutoff parameter of hot electrons. But they vary with respect to the spectral index non‐monotonously. As to the observed parameters in the Earth's inner magnetosphere, the speed, electric field strength, and the width of solitary electron acoustic wave are comparable with the observations.
RETRACTED: Efficient machine learning‐based hybrid resource allocation for device‐to‐device underlay communication in 5G wireless networks
Authors: Gopal Malle , T Velmurugan
Published: April 2024

Devices in close proximity can directly communicate with each other through device‐to‐device (D2D) communication, bypassing the need for base stations. To minimize the delay for D2D active clients, we use a sequential approach to reuse cellular‐type resources. Unlike conventional methods that focus solely on uplink or downlink resource distribution, our study introduces a novel optimization technique to maximize network throughput. Our proposal incorporates a hybrid approach that combines both downlink and uplink techniques for resource allocation. We utilize random forest and game theory algorithms to ensure smooth D2D communication while reducing interference between cellular and D2D pairings. Our hybrid structure effectively addresses challenges arising from intra‐ and inter‐cell interferences resulting from spectrum reusability and deployment. This approach also improves power control and quality of service. Traditionally, NP‐hard optimization solutions are proposed for mixed‐integer nonlinear problems. In our study, the critical stages include channel assignment and energy allocation. The objective problem in resource allocation considers parameters such as the transmission power of D2D active clients, cellular users, connection distance, base stations, and quality of service constraints. Our proposed hybrid method aims to enhance overall spectrum efficiency and network throughput. Simulated results demonstrate the superiority of our modified hybrid technique compared to existing joint resource allocation methods. This comprehensive approach represents a significant advancement in addressing the complexities associated with D2D communication, offering improved efficiency and performance in contemporary network environments.
Improving the Efficiency of Water Splitting and Oxygen Reduction Via Single‐Atom Anchoring on Graphyne Support
Authors: Talib Shamraiz Hussain , Bashir Beenish , Khan Muhammad Ajmal , Ali Babar , Mohamed Sharmarke , Qurashi Ahsanulhaq , Li Jun
Published: April 2024

Single‐atom catalysts (SACs) have received significant interest for optimizing metal atom utilization and superior catalytic performance in hydrogen evolution reaction (HER), oxygen evolution reaction (OER), and oxygen reduction reaction (ORR). In this study, we investigate a range of single‐transition metal (STM1 = Sc1, Ti1, V1, Cr1, Mn1, Fe1, Co1, Ni1, Cu1, Zr1, Nb1, Mo1, Ru1, Rh1, Pd1, Ag1, W1, Re1, Os1, Ir1, Pt1, and Au1) atoms supported on graphyne (GY) surface for HER/OER and ORR using first‐principle calculations. Ab initio molecular dynamics (AIMD) simulations and phonon dispersion spectra reveal the dynamic and thermal stabilities of the GY surface. The exceptional stability of all supported STM1 atoms within the H1 cavity of the GY surface exists in an isolated form, facilitating the uniform distribution and proper arrangement of single atoms on GY. In particular, Sc1, Co1, Fe1, and Au1/GY demonstrate promising catalytic efficiency in the HER due to idealistic ΔGH* values via the Volmer‐Heyrovsky pathway. Notably, Sc1 and Au1/GY exhibit superior HER catalytic activity compared to other studied catalysts. Co1/GY catalyst exhibits higher selectivity and activity for the OER, with an overpotential (0.46 V) comparable to MoC2, IrO2, and RuO2. Also, Rh1 and Co1/GY SACs exhibited promising electrocatalysts for the ORR, with an overpotential of 0.36 and 0.46 V, respectively. Therefore, Co1/GY is a versatile electrocatalyst for metal‐air batteries and water‐splitting. This study further incorporates computational analysis of the kinetic potential energy barriers of Co1 and Rh1 in the OER and ORR. A strong correlation is found between the estimated kinetic activation barriers for the thermodynamic outcomes and all proton‐coupled electron transfer steps. We establish a relation for the Gibbs free energy of intermediates to understand the mechanism of SACs supported on STM1/GY and introduce a key descriptor. This study highlights GY as a favorable single‐atom support for designing highly active and cost‐effective versatile electrocatalysts for practical applications.
Analytical identification of dynamic structural models: Mass matrix of an isospectral lumped mass model
Authors: Sivori Daniele , Lepidi Marco , Cattari Serena
Published: April 2024

Combining the accurate physical description of high‐fidelity mechanical formulations with the practical versatility of low‐order discrete models is a fundamental and open‐ended topic in structural dynamics. Finding a well‐balanced compromise between the opposite requirements of representativeness and synthesis is a delicate and challenging task. The paper systematizes a consistent methodological strategy to identify a physics‐based reduced‐order model (ROM) preserving the physical accuracy of large‐sized models with distributed parameters (REM), without resorting to classical techniques of dimensionality reduction. The leading idea is, first, to select a limited configurational set of representative degrees of freedom contributing significantly to the dynamic response (model reduction) and, second, to address an inverse indeterminate eigenproblem to identify the matrices governing the linear equations of undamped motion (structural identification). The physical representativeness of the identified model is guaranteed by imposing the exact coincidence of a selectable subset of natural frequencies and modes (partial isospectrality). The inverse eigenproblem is solved analytically and parametrically, since its indeterminacy can be circumvented by selecting the lumped mass matrix as the primary unknown and the stiffness matrix as a parameter (or vice versa). Therefore, explicit formulas are provided for the mass matrix of the ROM having the desired low dimension and possessing the selected partial isospectrality with the REM. Minor adjustments are also outlined to remove a posteriori unphysical effects, such as defects in the matrix symmetry, which are intrinsic consequences of the algebraic identification procedure. The direct and inverse eigenproblem solutions are explored through parametric analyses concerning a multistory frame, by adopting a high‐fidelity Finite Element model as REM and an Equivalent Frame model as ROM. Before mass matrix identification, modal analysis results indicate a general tendency of ROM to underestimate natural frequencies, with the underestimation strongly depending on the actual mass distribution of the structure. After the identification of the mass matrix and the elimination of unphysical defects, isospectrality is successfully achieved. Finally, extensions to prototypical highly massive masonry buildings are presented. The qualitative and quantitative discussion of the results under variation of the significant mechanical parameters provides useful insights to recognize the validity limits of the approximations affecting low‐order models with lumped parameters.
BlockSD‐5GNet: Enhancing security of 5G network through blockchain‐SDN with ML‐based bandwidth prediction
Authors: Rahman Anichur , Khan Md. Saikat Islam , Montieri Antonio , Islam Md. Jahidul , Karim Md. Razaul , Hasan Mahedi , Kundu Dipanjali , Nasir Mostofa Kamal , Pescapè Antonio
Published: April 2024

The fifth generation (5G) of mobile communications is the most exciting emerging technology for researchers and scientists to get the full benefit of a network system. However, 5G networks confront massive threats and vulnerabilities including protection, privacy, and secrecy. To face these challenges in the increasingly interconnected Internet of Things (IoT) scenario, we aim to leverage state‐of‐the‐art technologies as software defined networking (SDN) in conjunction with network function virtualization (NFV), blockchain, and machine learning (ML). Indeed, these technologies convey a robust and secure setting in the networking platform enabling to manage several criticalities related to security, privacy, flexibility, and performance. In light of these considerations, in this article, we propose the “BlockSD‐5GNet” architecture to efficiently improve the security of a 5G network and to exploit the combined advantages of Blockchain, SDN, NFV, and ML. In the proposed architecture, the SDN helps to manage the network by dividing it into data plane and control plane, while the Blockchain guarantees improved security and confidentiality. Therefore, the “BlockSD‐5GNet” architecture can both secure sensitive data and attain reliable data transfer within and between the 5G network‐infrastructure planes. Additionally, an ML module is integrated into the SDN controller to estimate network bandwidth and assist the administrator in taking effective decisions and satisfying high‐bandwidth demand. We assess the performance of the “BlockSD‐5GNet” architecture via an experimental evaluation performed in a simulation environment, and show the effectiveness of the proposed solution in comparison with baseline schemes. Finally, we also demonstrate the capability of different ML models in bandwidth prediction.
Research and mentorship in behavior analysis from a lens of cultural responsiveness and antiracism
Authors: Jimenez‐Gomez Corina
Published: April 2024

Although scientific endeavors strive to be objective, they are the work of individuals whose unique perspectives and experiences influence their research and interpretations of the world and data. Much has been said and written lately about the need to embed cultural responsiveness in behavior analysis and the need to enhance diversity in the field. In fact, similar conversations are taking place in many areas of science. Despite the current buzz, many behavioral researchers may be left wondering what they can do or whether it is incumbent on them to act. For the field of behavior analysis to move toward adopting the values of diversity, equity, inclusion, and access, members of the scientific community must actively engage in behaviors that foster inclusive and safe learning environments for students, engage in collaborative work, and incorporate culturally responsive research and mentorship practices. This article will describe some current practices, showcase exemplars of culturally responsive research and mentorship, and provide resources for researchers and mentors.
Triglicerydes/high‐density lipoprotein ratio as a risk factor of post‐Covid‐19 sinus tachycardia: A retrospective study
Authors: Kuryłowicz Alina , Babicki Mateusz , Wąsowski Michał , Jankowski Piotr , Kapusta Joanna , Chudzik Michał
Published: April 2024

Inappropriate sinus tachycardia (IST) is one of the manifestations of the post‐COVID‐19 syndrome (PCS), which pathogenesis remains largely unknown. This study aimed to identify potential risk factors for IST in individuals with PCS. The 1349 patients with PCS were included into the study. Clinical examination, 24H Holter ECG, 24H ambulatory blood pressure monitoring and biochemical tests were performed 12–16 weeks after the COVID‐19 in all participants. IST was found in 69 (3.5%) individuals. In the clinical assessment IST patients were characterized by a higher age (p < 0.001) and lower prevalence of the diagnosed hypertension (p = 0.012), compared to remaining patients. Biochemical testing showed higher serum triglycerides (1.66 vs. 1.31 pmol/L, p = 0.007) and higher prevalence of a low high‐density lipoprotein (HDL) cholesterol (24.6% vs. 15.2%, p = 0.035) in the IST group. Subsequently, the triglicerydes (TG)/HDL ratio, an indicator of insulin resistance, was significantly higher in the IST individuals (3.2 vs. 2.4, p = 0.005). 24H monitoring revealed a significantly higher minimum diastolic, maximum systolic and mean arterial blood pressure values in the IST group (p < 0.001 for all), suggesting a high prevalence of undiagnosed hypertension. A multivariate analysis confirmed the predictive value TG/HDL ratio >3 (OR 2.67, p < 0.001) as predictors of IST development. A receiver operating characteristic curve analysis of the relationship between the TG/HDL ratio and the IST risk showed that the predictive cut‐off point for this parameter was 2.46 (area under the ROC curve = 0.600, p = 0.004). Based on these findings, one can conclude that insulin resistance seems to be a risk factor of IST, a common component of PCS.
Impact of cannabidiol on brain glucose metabolism of C57Bl/6 male mice previously exposed to cocaine
Authors: Spelta Lidia Emmanuela Wiazowski , Real Caroline Cristiano , Bruno Vitor , Buchpiguel Carlos Alberto , Garcia Raphael Caio Tamborelli , Torres Larissa Helena , de Paula Faria Daniele , Marcourakis Tania
Published: April 2024

Despite evidence of the beneficial effects of cannabidiol (CBD) in animal models of cocaine use disorder (CUD), CBD neuronal mechanisms remain poorly understood. This study investigated the effects of CBD treatment on brain glucose metabolism, in a CUD animal model, using [18F]FDG positron emission tomography (PET). Male C57Bl/6 mice were injected with cocaine (20 mg/kg, i.p.) every other day for 9 days, followed by 8 days of CBD administration (30 mg/kg, i.p.). After 48 h, animals were challenged with cocaine. Control animals received saline/vehicle. [18F]FDG PET was performed at four time points: baseline, last day of sensitization, last day of withdrawal/CBD treatment, and challenge. Subsequently, the animals were euthanized and immunohistochemistry was performed on the hippocampus and amygdala to assess the CB1 receptors, neuronal nuclear protein, microglia (Iba1), and astrocytes (GFAP). Results showed that cocaine administration increased [18F]FDG uptake following sensitization. CBD treatment also increased [18F]FDG uptake in both saline and cocaine groups. However, animals that were sensitized and challenged with cocaine, and those receiving only an acute cocaine injection during the challenge phase, did not exhibit increased [18F]FDG uptake when treated with CBD. Furthermore, CBD induced modifications in the integrated density of NeuN, Iba, GFAP, and CB1R in the hippocampus and amygdala. This is the first study addressing the impact of CBD on brain glucose metabolism in a preclinical model of CUD using PET. Our findings suggest that CBD disrupts cocaine‐induced changes in brain energy consumption and activity, which might be correlated with alterations in neuronal and glial function.
Ocular endothelial dysfunction in pediatric inflammatory bowel disease
Authors: Di Nardo Giovanni , Di Pippo Mariachiara , Zenzeri Letizia , Mennini Maurizio , Piccirillo Marisa , Furio Silvia , Quatrale Giovanna , Evangelisti Melania , Parisi Pasquale , Lucchini Livia , Ferretti Alessandro , Villa Maria Pia , Scuderi Gianluca , Amadè David Sarzi , Abdolrahimzadeh Solmaz
Published: April 2024

Objectives

To assess ocular microvasculature changes using optical coherence tomography angiography (OCTA) in pediatric patients with inflammatory bowel disease (IBD).

Methods

Patients (aged 6–18 years) with IBD were recruited between September 2021 and May 2023. All eligible participants underwent comprehensive clinical assessment and laboratory investigation. Patients with functional gastrointestinal disorders served as the controls. This study assessed specific IBD phenotypes, disease duration, clinical and endoscopic activity indices, laboratory markers, and medication histories. OCTA was utilized to evaluate ocular microvasculature changes in both groups.

Results

A total of 63 children (mean age 12.9 ± 3.3 years) were enrolled, comprising 38 in the IBD group (16 ulcerative colitis, 22 Crohn's disease, and 25 in the control group). Most patients in the IBD group were in remission or had mild‐to‐moderate disease activity at enrollment. Analysis of the OCTA results revealed significant differences in the choroidal luminal area and total choroidal area between the IBD and control groups.

Conclusions

The study identified distinct ocular microvasculature changes in pediatric IBD patients through OCTA, suggestive of potential systemic endothelial dysfunction. These findings underscore the utility of OCTA in evaluating microvascular alterations associated with pediatric IBD, offering insights into potential systemic complications linked to inflammation in IBD patients.
Study on the components changes of polysaccharides and saponins during nine steaming and drying of Polygonatum sibiricum
Authors: Zhang Qihong , Lin Xinyu , Su Weike
Published: April 2024

BACKGROUND

In this study, the content and structure of Polygonatum sibiricum polysaccharides and saponins during different processing stages were determined.

RESULTS

After processing of Polygonatum, the content of polysaccharide and glucose decreased, and the content of galactose, glucuronic acid and sugar substitution gradually increased. The content of total saponins increased significantly. Only 18 compounds were found in raw Polygonatum and 17 new compounds were presented in processed Polygonatum. During the processing of Polygonatum, the polysaccharide was partially degraded into oligosaccharides, the molecular weight gradually decreased, and the neutral sugar was converted into uronic acid, resulting in a decrease in polysaccharide content. The saponins were partially degraded into sapogenins or modified.

CONCLUSION

This study clarifies the changes in the content and structure of polysaccharides and saponins in processed Polygonatum, which will pave the way for elucidating the processing mechanism. © 2024 Society of Chemical Industry.
Moose and white‐tailed deer mortality peaks in fall and late winter
Authors: Wehr Nathaniel H. , Moore Seth A. , Isaac Edmund J. , Kellner Kenneth F. , Millspaugh Joshua J. , Belant Jerrold L.
Published: April 2024

The Grand Portage Band of Lake Superior Chippewa manages for sustainable subsistence harvests of moose (mooz; Alces alces) and white‐tailed deer (waawaashkeshi; Odocoileus virginianus). Moose populations in northern Minnesota, USA, are declining, which may necessitate alterations to Indigenous subsistence practices. Moose and deer exhibit seasonal behaviors such as altered space use and movement strategies, to which gray wolves (ma'iingan; Canis lupus) and humans may adapt, resulting in seasonal mortality patterns. Identifying periods of increased moose and deer vulnerability is important for achieving tribal conservation objectives. We assessed seasonal cause‐specific mortality of adult moose (2010–2021) and deer (2016–2022) fitted with global positioning system collars on and near the Grand Portage Indian Reservation (Gichi Onigaming; GPIR) in Minnesota and hypothesized mortality risk would be influenced by species‐specific space use patterns and weather. We estimated survival rates and mortality risk using time‐to‐event models. We recorded 42 moose mortalities (17 health issues, 8 predations, 4 subsistence harvests, 13 unknown causes) and 49 deer mortalities (26 predations, 13 harvests, 4 other causes, 6 unknown causes). Mean annual moose survival was 83.2%, and mortality risk peaked during late winter (~25 April) and fall (~8 October). Mean annual deer survival was 48.0%, and mortality risk peaked during late winter (~25 March) and during their fall migration period (~11 November). Mortality timing coincided with transitions between space use states (i.e., periods of spatial stability), suggesting ungulates are at greater risk during these transitional periods, though movement strategy (i.e., resident vs. migratory) did not influence mortality risk. Further, increased winter severity corresponded with increased deer mortality. We observed similar temporal peaks in mortality risk when harvest mortalities were censored, suggesting our observed seasonal mortality peaks occur naturally despite harvest comprising most fall deer mortality. Our results can inform population models and harvest regulations by identifying periods of mortality risk on GPIR under Anishinaabe principles of seventh‐generation conservation planning.
Evaluation of reaction rate of thermogravimetric analysis data using periodic sinc function interpolation
Authors: Aghili Alireza , Shabani Amir Hossein
Published: April 2024

The periodic sinc function interpolation offers a compelling solution to address the issue of noise in the analysis of thermogravimetric analysis (TGA) data, thereby enhancing the outcomes of differential techniques such as the Friedman isoconversional method. In this study, we introduce a novel approach that leverages the periodic sinc function interpolation to directly obtain smooth reaction rates from TGA data, eliminating the reliance on numerical differentiation methods. The efficacy of this method has been confirmed through its application to noisy experimental data derived from the thermal decomposition of various polymers, showcasing its robustness. Readers are provided with the corresponding code for Gnu Octave, serving as a free alternative to MATLAB. Additionally, the activation energies calculated from the experimental data using both the Friedman method and periodic sinc function interpolation closely align with those determined by the integral Vyazovkin method, emphasizing the validity and reliability of this new approach.
High Space‐Bandwidth‐Product (SBP) Hologram Carriers Toward Photorealistic 3D Holography
Authors: Li Jin , Li Xiaoxun , Huang Xiangyu , Kaissner Robin , Neubrech Frank , Sun Shuo , Liu Na
Published: April 2024

3D holography capable of reproducing all necessary visual cues is considered the most promising route to present photorealistic 3D images. Three elements involving computer‐generated hologram (CGH) algorithms, hologram carriers, and optical systems are prerequisites to create high‐quality holographic displays for photorealistic 3D holography. Especially, the hologram carrier directly determines the holographic display capability and the design of high space‐bandwidth‐product (SBP) optical systems. Currently, two categories of hologram carriers, i.e., spatial light modulators (SLM) and metasurfaces, are regarded as promising candidates for photorealistic 3D holography. However, most of their SBP capability still cannot match the amount of information generated by the CGH. To address this issue, tremendous efforts are made to improve the capability of hologram carriers. Here, the main hologram carriers (from SLM to metasurfaces) that are widely utilized in holography systems to achieve high SBP capability (high resolution, wide viewing angles, and large sizes) are reviewed. The purpose of this review is to identify the key challenges and future directions of SLM‐based and metasurface‐based holography for photorealistic 3D holographic images.
Determinants of remote measurement‐based care uptake in a safety net outpatient psychiatry department as part of learning health system transition
Authors: Aldis Rajendra , Rosenfeld Lisa C. , Mulvaney‐Day Norah , Lanca Margaret , Zona Kate , Lam Jeffrey A. , Asfour Julia , Meltzer Jonah C. , Leff H. Stephen , Fulwiler Carl , Wang Philip , Progovac Ana M.
Published: April 2024

Introduction

Behavioral measurement‐based care (MBC) can improve patient outcomes and has also been advanced as a critical learning health system (LHS) tool for identifying and mitigating potential disparities in mental health treatment. However, little is known about the uptake of remote behavioral MBC in safety net settings, or possible disparities occurring in remote MBC implementation.

Methods

This study uses electronic health record data to study variation in completion rates at the clinic and patient level of a remote MBC symptom measure tool during the first 6 months of implementation at three adult outpatient psychiatry clinics in a safety net health system. Provider‐reported barriers to MBC adoption were also measured using repeated surveys at one of the three sites.

Results

Out of 1219 patients who were sent an MBC measure request, uptake of completing at least one measure varied by clinic: General Adult Clinic, 38% (n = 262 of 696); Substance Use Clinic, 28% (n = 73 of 265); and Transitions Clinic, 17% (n = 44 of 258). Compared with White patients, Black and Portuguese or Brazilian patients had lower uptake. Older patients also had lower uptake. Spanish language of care was associated with much lower uptake at the patient level. Significant patient‐level disparities in uptake persisted after adjusting for the clinic, mental health diagnoses, and number of measure requests sent. Providers cited time within visits and bandwidth in their workflow as the greatest consistent barriers to discussing MBC results with patients.

Conclusions

There are significant disparities in MBC uptake at the patient and clinic level. From an LHS data infrastructure perspective, safety net health systems may need to address the need for possible ways to adapt MBC to better fit their populations and clinical needs, or identify targeted implementation strategies to close data gaps for the identified disparity populations.
Motor Complications in Parkinson's Disease: Results from 3343 Patients Followed for up to 12 Years
Authors: Gandhi Sacha E. , Zerenner Tanja , Nodehi Anahita , Lawton Michael A. , Marshall Vicky , Al‐Hajraf Falah , Grosset Katherine A. , Morris Huw R. , Hu Michele T. , Ben‐Shlomo Yoav , Grosset Donald G.
Published: April 2024

Background

Motor complications are well recognized in Parkinson's disease (PD), but their reported prevalence varies and functional impact has not been well studied.

Objectives

To quantify the presence, severity, impact and associated factors for motor complications in PD.

Methods

Analysis of three large prospective cohort studies of recent‐onset PD patients followed for up to 12 years. The MDS‐UPDRS part 4 assessed motor complications and multivariable logistic regression tested for associations. Genetic risk score (GRS) for Parkinson's was calculated from 79 single nucleotide polymorphisms.

Results

3343 cases were included (64.7% male). Off periods affected 35.0% (95% CI 33.0, 37.0) at 4–6 years and 59.0% (55.6, 62.3) at 8–10 years. Dyskinesia affected 18.5% (95% CI 16.9, 20.2) at 4–6 years and 42.1% (38.7, 45.5) at 8–10 years. Dystonia affected 13.4% (12.1, 14.9) at 4–6 years and 22.8% (20.1, 25.9) at 8–10 years. Off periods consistently caused greater functional impact than dyskinesia. Motor complications were more common among those with higher drug doses, younger age at diagnosis, female gender, and greater dopaminergic responsiveness (in challenge tests), with associations emerging 2–4 years post‐diagnosis. Higher Parkinson's GRS was associated with early dyskinesia (0.026 ≤ P ≤ 0.050 from 2 to 6 years).

Conclusions

Off periods are more common and cause greater functional impairment than dyskinesia. We confirm previously reported associations between motor complications with several demographic and medication factors. Greater dopaminergic responsiveness and a higher genetic risk score are two novel and significant independent risk factors for the development of motor complications.
Bodily Maps of Symptoms and Emotions in Parkinson's Disease
Authors: Niemi Kalle J. , Huovinen Annu , Jaakkola Elina , Glerean Enrico , Nummenmaa Lauri , Joutsa Juho
Published: April 2024

Background

Emotions are reflected in bodily sensations, and these reflections are abnormal in psychiatric conditions. However, emotion‐related bodily sensations have not been studied in neurological disorders.

Objective

The aim of this study was to investigate whether Parkinson's disease (PD) is associated with altered bodily representations of emotions.

Methods

Symptoms and emotion‐related sensations were investigated in 380 patients with PD and 79 control subjects, using a topographical self‐report method, termed body sensation mapping. The bodily mapping data were analyzed with pixelwise generalized linear models and principal component analyses.

Results

Bodily maps of symptoms showed characteristic patterns of PD motor symptom distributions. Compared with control subjects, PD patients showed decreased parasternal sensation of anger, and longer PD symptom duration was associated with increased abdominal sensation of anger (PFWE < 0.05). The PD‐related sensation patterns were abnormal across all basic emotions (P < 0.05).

Conclusions

The results demonstrate altered bodily maps of emotions in PD, providing novel insight into the nonmotor effects of PD. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
A Novel PINK1 p.F385S Loss‐of‐Function Mutation in an Indian Family with Parkinson's Disease
Authors: Sharma Karan , Kishore Asha , Lechado‐Terradas Anna , Passannanti Raffaele , Raimondi Francesco , Sturm Marc , Sreelatha Ashwin Ashok Kumar , Puthenveedu Divya Kalikavila , Sarma Gangadhara , Casadei Nicolas , Krüger Rejko , Gasser Thomas , Kahle Philipp , Riess Olaf , Fitzgerald Julia C. , Sharma Manu
Published: April 2024

Background

Most Parkinson's disease (PD) loci have shown low prevalence in the Indian population, highlighting the need for further research.

Objective

The aim of this study was to characterize a novel phosphatase tensin homolog‐induced serine/threonine kinase 1 (PINK1) mutation causing PD in an Indian family.

Methods

Exome sequencing of a well‐characterized Indian family with PD. A novel PINK1 mutation was studied by in silico modeling using AlphaFold2, expression of mutant PINK1 in human cells depleted of functional endogenous PINK1, followed by quantitative image analysis and biochemical assessment.

Results

We identified a homozygous chr1:20648535–20648535 T>C on GRCh38 (p.F385S) mutation in exon 6 of PINK1, which was absent in 1029 genomes from India and in other known databases. PINK1 F385S lies within the highly conserved DFG motif, destabilizes its active state, and impairs phosphorylation of ubiquitin at serine 65 and proper engagement of parkin upon mitochondrial depolarization.

Conclusions

We characterized a novel nonconservative mutation in the DFG motif of PINK1, which causes loss of its ubiquitin kinase activity and inhibition of mitophagy. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
System restructuring in Iowa would integrate substance use care
Authors: Enos Gary
Published: April 2024

Mental health advocates in Iowa have expressed cautious optimism that a proposed system restructuring that is under consideration in the state legislature would result in more equitable and navigable services for the state's residents.
Single/bidirectional pattern and beamwidth reconfigurable array antenna using reconfigurable reflecting surface
Authors: Prakash Tarun , Chaudhary Raghvendra Kumar , Gangwar Ravi Kumar
Published: April 2024

This study describes an array antenna that allows for reconfiguration of the three significant antenna properties, that is, radiation pattern, half‐power beamwidth (HPBW), and single and bi‐directional beam. A reconfigurable reflecting surface (RRS) has been designed and incorporated with the array antenna on the top and bottom. The RRS works to reflect or pass the incident electromagnetic wave. It enables us to reconfigure from single to multibeam radiation in the ±z direction. It also provides two levels of HPBW, that is, 49.6° and 95°. Eventually, the same three sets of antennae have been stacked and rotated with a 60° angle to achieve the radiation pattern reconfiguration in the entire azimuth plane. It conforms to reconfigure all three antenna properties in six directions at an equal interval of 60° angle. The achieved maximum gain in a narrow beam is 9.56 dBi. The proposed reconfigurable antenna array can be used in modern wireless communication applications.
Estimation of the relative biological effectiveness for double strand break induction of clinical kilovoltage beams using Monte Carlo simulations
Authors: McElligott Oran , Nikandrovs Mihails , McCavana Patrick , McClean Brendan , León Vintró Luis
Published: April 2024

Background

The Relative Biological Effectiveness (RBE) of kilovoltage photon beams has been previously investigated in vitro and in silico using analytical methods. The estimated values range from 1.03 to 1.82 depending on the methodology and beam energies examined.

Purpose

The focus of this work was to independently estimate RBE values for a range of clinically used kilovoltage beams (70–200 kVp) while investigating the suitability of using TOPAS‐nBio for this task.

Methods

Previously validated spectra of clinical beams were used to generate secondary electron spectra at several depths in a water tank phantom via TOPAS Monte Carlo (MC) simulations. Cell geometry was irradiated with the secondary electrons in TOPAS‐nBio MC simulations. The deposited dose and the calculated number of DNA strand breaks were used to estimate RBE values.

Results

Monoenergetic secondary electron simulations revealed the highest direct and indirect double strand break yield at approximately 20 keV. The average RBE value for the kilovoltage beams was calculated to be 1.14.

Conclusions

TOPAS‐nBio was successfully used to estimate the RBE values for a range of clinical radiotherapy beams. The calculated value was in agreement with previous estimates, providing confidence in its clinical use in the future.
Full‐dose whole‐body PET synthesis from low‐dose PET using high‐efficiency denoising diffusion probabilistic model: PET consistency model
Authors: Pan Shaoyan , Abouei Elham , Peng Junbo , Qian Joshua , Wynne Jacob F , Wang Tonghe , Chang Chih‐Wei , Roper Justin , Nye Jonathon A , Mao Hui , Yang Xiaofeng
Published: April 2024

Purpose

Positron Emission Tomography (PET) has been a commonly used imaging modality in broad clinical applications. One of the most important tradeoffs in PET imaging is between image quality and radiation dose: high image quality comes with high radiation exposure. Improving image quality is desirable for all clinical applications while minimizing radiation exposure is needed to reduce risk to patients.

Methods

We introduce PET Consistency Model (PET‐CM), an efficient diffusion‐based method for generating high‐quality full‐dose PET images from low‐dose PET images. It employs a two‐step process, adding Gaussian noise to full‐dose PET images in the forward diffusion, and then denoising them using a PET Shifted‐window Vision Transformer (PET‐VIT) network in the reverse diffusion. The PET‐VIT network learns a consistency function that enables direct denoising of Gaussian noise into clean full‐dose PET images. PET‐CM achieves state‐of‐the‐art image quality while requiring significantly less computation time than other methods. Evaluation with normalized mean absolute error (NMAE), peak signal‐to‐noise ratio (PSNR), multi‐scale structure similarity index (SSIM), normalized cross‐correlation (NCC), and clinical evaluation including Human Ranking Score (HRS) and Standardized Uptake Value (SUV) Error analysis shows its superiority in synthesizing full‐dose PET images from low‐dose inputs.

Results

In experiments comparing eighth‐dose to full‐dose images, PET‐CM demonstrated impressive performance with NMAE of 1.278 ± 0.122%, PSNR of 33.783 ± 0.824 dB, SSIM of 0.964 ± 0.009, NCC of 0.968 ± 0.011, HRS of 4.543, and SUV Error of 0.255 ± 0.318%, with an average generation time of 62 s per patient. This is a significant improvement compared to the state‐of‐the‐art diffusion‐based model with PET‐CM reaching this result 12× faster. Similarly, in the quarter‐dose to full‐dose image experiments, PET‐CM delivered competitive outcomes, achieving an NMAE of 0.973 ± 0.066%, PSNR of 36.172 ± 0.801 dB, SSIM of 0.984 ± 0.004, NCC of 0.990 ± 0.005, HRS of 4.428, and SUV Error of 0.151 ± 0.192% using the same generation process, which underlining its high quantitative and clinical precision in both denoising scenario.

Conclusions

We propose PET‐CM, the first efficient diffusion‐model‐based method, for estimating full‐dose PET images from low‐dose images. PET‐CM provides comparable quality to the state‐of‐the‐art diffusion model with higher efficiency. By utilizing this approach, it becomes possible to maintain high‐quality PET images suitable for clinical use while mitigating the risks associated with radiation. The code is availble at https://github.com/shaoyanpan/Full‐dose‐Whole‐body‐PET‐Synthesis‐from‐Low‐dose‐PET‐Using‐Consistency‐Model.
Cosmetic and functional impact of fascia lata harvest for use in surgery for stress urinary incontinence
Authors: Johnson Colin , Vollstedt Annah , Nakatsuka Hannah , Orzel Joanna , Takacs Elizabeth B.
Published: April 2024

Introduction

There has been increased interest in using autologous tissues since the Food and Drug Administration banned transvaginal mesh for pelvic organ prolapse in 2019. Our study aims to assess patients’ perspective of functional and cosmetic impact on the fascia lata harvest site in patients undergoing fascia lata harvest for the treatment of stress urinary incontinence (SUI).

Methods

This is a prospective survey study of a retrospective cohort of patients who underwent a fascia lata pubovaginal sling between 2017 and 2022. Participants completed a survey regarding the functional and cosmetic outcomes of the harvest site.

Results

Seventy‐two patients met the inclusion criteria. Twenty‐nine patients completed the survey for a completion rate of 40.3%. For functional symptoms, 24.1% (7/29) of patients reported leg discomfort, 10.3% (3/29) reported leg weakness, 10.3% (3/29) reported a bulge, 17.2% (5/29) reported scar pain, 14.8% (4/27) reported scar numbness, and 17.2% (5/29) reported paresthesia at the scar. For cosmetic outcomes, 72.4% (21/29) reported an excellent or good scar appearance. On the PGI‐I, 75.9% (22/29) reported their condition as very much better (48.3%, 14/29) or much better (27.6%, 8/29).

Conclusions

The majority of patients reported being satisfied with the functional and cosmetic outcomes of their harvest site as well as satisfied with the improvement in their SUI. Less than 25% of patients report harvest site symptoms, including leg weakness, scar bulging, scar pain, scar numbness, or paresthesia in the scar. This is important in the context of appropriate preoperative discussion and counseling regarding fascia lata harvest.
Harvest of large fascia lata autograft: Outcomes in 108 patients
Authors: Delu Ava A. , Terrani Kristina F. , Funk Joel T. , Twiss Christian O.
Published: April 2024

Purpose

Due to the reclassification of transvaginal mesh as a high‐risk device, there has been renewed interest in the use of fascia lata in pelvic floor reconstruction. Here we report our experience in 108 patients who underwent large fascia lata harvest for pelvic organ prolapse (POP) repair. Our primary objective was to highlight the postoperative morbidity of the large fascia lata harvest in patients who underwent POP repair using fascia lata autograft.

Methods

Surgery involved harvesting a fascia lata graft through a small lateral upper thigh incision and was used for either autologous transvaginal POP repair or autologous sacrocolpopexy. To prevent seroma, a temporary Jackson‐Pratt drain was intraoperatively placed and a mild compression wrap was applied to the area for 4–6 weeks postoperatively. Patient demographics were obtained preoperatively, while physical exam findings and postoperative outcomes related to the fascia lata harvest were collected at sequential follow up visits.

Results

One‐hundred eight patients underwent 111 large fascia lata harvests for either transvaginal or abdominal/robotic POP repair from July 2016 to January 2022. Mean follow‐up was 19.6 months (range: 1–65) with 38 patients having 24 months or more of follow‐up. Mean Visual Analog Pain (VAP) score was 1 (range: 0–10). Sixteen patients developed asymptomatic thigh bulges, 16 patients developed harvest site seromas (of which 14 resolved), and 59 patients experienced mild, non‐bothersome paresthesia near the incision.

Conclusion

Large fascia lata harvest offers a robust autograft for transvaginal or transabdominal POP repair with minimal morbidity. Harvest site complications are minor and typically resolve with expectant management. This technique can be safely utilized in patients who desire graft‐augmented repair of POP without the use of synthetic mesh, allograft, or xenograft.