bluuebunny/crossref_metadata_2025 huggingface dataset:
Yu. N. Solonin on the socio-political philosophy of conservatism
Authors:   St. Petersburg State University, Osipov Igor D.
Published: January 2023

Professor of the St Petersburg State University Yu. N. Solonin to the study of global and Russian conservatism, analyzes his works on the problems of philosophy and axiology of politics and political ideology. The author shows that political philosophy of Solonin was theoretically grounded Center for comprehensive study of conservatism at the Philosophy Department of the St Petersburg State University. It is pointed out that many well-known specialists from St Petersburg and other regions of Russia took an active part in the work for the Study of Conservatism Center. They investigated the substantial characteristics of conservatism as a complex socio-cultural and intellectual phenomenon and the historical-philosophical preconditions of conservatism. Solonin’s works creatively developed the concepts by Russian scholars dealt with conservatism, and it helped to organize a research school of comprehensive study of conservatism. The article offers an analysis of Solonin’s writings on conservatism while he was leading the Study of Conservatism Center. The works by Solonin and other scholars revealed the main features of conservatism’s philosophy, such as holism, organicism, traditionalism, etatism, and irrationalism; they analyzed the historical, cultural, political-legal and socioeconomic preconditions of the genesis of European and Russian conservatism. The article argues that a special attention in Solonin’s theoretical heritage was paid to the analysis of the problem of liberal-conservative synthesis. He specifically analyzed the potentialities of liberalconservative synthesis and proved that various non-classical forms of political ideologies are being formed in modern conditions. Solonin also noted the complex and diverse ideological currents of conservatism in Russia, its being conditioned by the traditional way of Russian society, the attitude of the people to the state.
The role of management consciousness in the social and information environment in the situation global instability
Authors:   Ryazan State Radio Engineering University named after V.F.Utkin, Arutiunian Karine S.
Published: January 2023

This article provides the socio-philosophical analysis of the managerial consciousness as a tool in overcoming crisis trends in the social and information environment (at the example of two spheres). In the contemporary world, there is a contradiction between consciousness and matter, spirit and body. These contradictions exacerbate the problems of interaction between the society and the environment. The main environmental difficulties are due to the nature of the modern material production, the lifestyle and the value orientation of the individual. Also, information resources are actively being introduced into the life of a contemporary person. In addition, the emergence of the information space contributes to the formation of a global information environment, the formation of an “information society,” the basis of which becomes the generation, processing, transmission, and updating information. The humanity has come to the point where modern civilization, called global, technogenic and consumer, has discovered its crisis, instability caused by the growth of environmental problems, information risks. The purpose of the article is use the methodology of socio-philosophical analysis for identifying problems and demonstrating the role of managerial consciousness in the socionatural and information environment. The research significance of the work is aimed at introducing the scientific categories of “ecological and managerial consciousness” and “consciousness management in the information space” into social philosophy. The practical component is the definition of the role of managerial consciousness in social spheres (environmental and information) in order to form value orientations and relationships that will allow harmoniously developing the system of society-person relations. This research is the development of the theoretical and methodological foundations of social philosophy, ecology, management for further introduction into the practice of social management.
The correlation of the concepts of Madhyamaka and Yogācāra in Nāgārjuna’s “Bodhicittavivarana”
Authors:   Institute for Mongolian, Buddhist and Tibetan Studies, Russian Academy of Sciences, Siberian Branch, Lepekhov Sergey Yu.
Published: January 2023

Nāgārjuna — the founder of Mahayana school Madhyamaka — is also a well-known logician, polemist and the author of several famous treatises, such as “Bodhicittavivarana” (“Commentary on Bodhicitta”). This commentary is one of the most cited in Indian philosophical literature, and, notwithstanding it’s dubious origin, belongs to the authorship of Nāgārjuna. The main feature of this text is the description of the concepts of Madhyamaka and Yogācāra, which elaborate each other and not differs. The basic concept of Madhyamaka — “çūnyatā” (“the emptiness”) is expanded through the other important category “bodhicitta” (“the attainment of Enlightenment”). The differences between the phenomenal truth (“samvrtti”) and the ignorance (“avidyā”), Nāgārjuna’s analysis of Sarvastivāda and Yogācāra as the schools, representing only the phenomenal truth and Yogācāra’s argumentation, substantiating the existence of the “only-consciousness” are analyzed on the base of “Bodhicittavivarana”. Nāgārjuna’s argument is considered, based on the impossibility of implication between permanent and non-permanent objects. It is shown that the “three natures” of Yogācāra, as Nāgārjuna proves, cannot be graded, as they have one nature — the nature of çūnyatā. This text using the methodology of Madhyamaka is an example of the most follow-up un-contradictory unification of the concepts of various Buddhist schools (as well as Yogācāra). The author’s translation of “Bodhicittavivarana” from Sanskrit and Tibetan is given in attachment.
Inovações: Editorial
Authors: Trindade da Silva Lucas
Published: January 2023

A edição número 33 da Inter-legere, Revista de Pós-Graduação em Ciências Sociais da UFRN, abre 2022 com duas mudanças significativas. Formalmente, a partir desta edição, a Inter-Legere uniformizará o padrão estético das suas capas, em termos de layout e fontes, alterando a cada edição apenas a cor de fundo. Do ponto de vista da lógica editorial, esta edição inaugura a adoção do padrão de publicação em fluxo contínuo, o que permite maior celeridade tanto na composição das edições como na publicação de artigos aceitos, revisados e diagramados, ponto positivo para a equipe editorial e para autoras e autores. Neste número, além deste editorial, publicamos 6 artigos livres e 1 entrevista.
In an Online Nutrition Education Program Delivered to University Students, Group Interaction was Key to Increasing Food Literacy
Authors: Brito Porciúncula Laura , Melo de Araujo Joana Yasmin , De Oliveira Lino Giuliana , Jacob de Menezes Neto Elias , Gomes Sávio , Cristine Medeiros Jacob Michelle
Published: January 2023

Our goal was to test an online nutrition education program delivered using social media platforms on the food literacy levels of university students. We experimented with students from universities in northeastern Brazil, organized into three groups: an intervention group (A), which accessed the program content on social media platforms and participated in online activities as a group; a positive control group (B), which only accessed the content of our program on social media platforms; and, finally, a negative control group (C). We applied to all groups a pre- and post-assessment questionnaire on food literacy self-perception. Within groups, the increase in food literacy score was significant only in group A (8.15 ± 13.98), demonstrating the effectiveness of our program. However, comparison among groups showed that accessing the content on social media platforms by itself had no effect on food literacy (group B: 4.88 ± 11.13 and C: 0.16 ± 5.88). Interaction in a small group was key to increasing food literacy. We hope our study can foster a better understanding of how online nutrition education programs are assessed, considering that metrics provided by social media platforms do not inform about educational outcomes.
The Use of Surface Plasmon Resonance to Study the Interactions of
Proteins Involved in Conformational Diseases: Experimental
Approaches for New Therapeutical Perspectives
Authors: Zingale Gabriele Antonio , Distefano Alessia , Grasso Giuseppe
Published: January 2023

In recent years, the scientific community has been trying to tackle different diseases
by using unifying and holistic approaches based on the concept that it is possible to
target apparently very different diseases under a comprehensive general scheme. In other
words, various different diseases have been grouped together under the label of “conformational
diseases”, because the triggering cause for each malady is the misfolding of a
specific protein, whose dyshomeostasis and accumulation cause all the other downhill
biomolecular events characteristic of each different disease. In a parallel manner, analytical
techniques have developed to investigate protein misfolding and accumulation, so as
to give a valid technical support to the investigation of conformational diseases. In this
scenario, surface plasmon resonance (SPR) has widely contributed to study many different
aspects correlated to conformational diseases, offering the advantages of real time investigations,
use of small amounts of biological materials and possibility to mimic the cellular
environments without recurring to the use of fluorescent tags. In this review, after a
brief introduction about conformational diseases and the SPR technique, a thorough description
of the various uses of SPR to investigate the biomolecular mechanisms involved
in these diseases is given in order to provide the reader with an exhaustive list as
well as a critical perspective of the use of SPR for such topic. The case of Alzheimer’s
disease is discussed at a deeper level. We hope that this work will make the reader aware
of all the possible SPR experimental approaches, which can be used to develop new possible
therapeutic strategies to tackle conformational diseases.
Flavonoids-mediated TLR4 Inhibition as a Promising Therapy for Renal Diseases
Authors: Mahmoud Ayman M. , Sayed Ahmed M. , Ahmeda Ahmed F. , Abd-Alhameed Esraa K. , Salem Shimaa H. , Alruhaimi Reem S. , Shukur Ali , Hassanein Emad H.M.
Published: January 2023

Toll-like receptors (TLRs) control both innate and adaptive immunity with a wide expression on renal epithelial cells and leukocytes. Activation of TLRs results in the production of cytokines, chemokines and interferons along with activation of the transcription factor NF-κB, resulting in inflammatory perturbations. TLR4 signaling pathway is the most extensively studied of TLRs. TLR4 is expressed on renal microvascular endothelial and tubular epithelial cells. So, targeting TLR4 modulation could be a therapeutic approach to attenuate kidney diseases that are underlined by inflammatory cascade. Medicinal plants with anti-inflammatory activities display valuable effects and are employed as alternative sources to alleviate renal disease linked with inflammation. Flavonoids and other phytochemicals derived from traditional medicines possess promising pharmacological activities owing to their relatively cheap and high safety profile. Our review focuses on the potent anti-inflammatory activities of twenty phytochemicals to verify if their potential promising renoprotective effects are related to suppression of TLR4 signaling in different renal diseases, including sepsis-induced acute kidney injury, renal fibrosis, chemotherapy-induced nephrotoxicity, diabetic nephropathy and renal ischemia/reperfusion injury. Additionally, molecular docking simulations were employed to explore the potential binding affinity of these phytochemicals to TLR4 as a strategy to attenuate renal diseases associated with activated TLR4 signaling.
Herb-Drug Interactions and Their Impact on Pharmacokinetics: An Update
Authors: Cheng Wenhao , Xia Kexin , Wu Siyang , Li Yingfei
Published: January 2023

Herb medicine has a long history of application and is still used worldwide. With the development of complementary and alternative medicine, the interaction between herb and drugs has attracted more and more attention. Herb-drug interactions (HDI) could cause decreased efficiency, increased toxicity, and affect the drug absorption and disposition processes due to the interference of their pharmacological or pharmacokinetic effects. Hence, the mechanisms and results of herb-pharmacokinetic interactions should be comprehensively summarized. Here, we have summarized the mechanisms of HDI and pharmacokinetic interactions in the last ten years based on searching on PubMed, Science Direct, and Web of Science with different keywords. Besides, the pharmacokinetic interactions were related to nine commonly used herbs and drugs, including Ginseng, Salvia miltiorrhiza, Ginkgo biloba, Garlic, Coptis chinensis, St. John's wort, Ginger, Licorice, Silythistle and Fructus Schisandrae. This review provides an overview of HDI to provide a reference for the rational and safe clinical use of herbs and drugs.
Poly(Glutamic Acid)-Engineered Nanoplatforms for Enhanced Cancer
Phototherapy
Authors: Zhang Yu , Lu Yiming , Li Yicong , Xu Yixin , Song Wenliang
Published: January 2023

Phototherapies, including photothermal therapy and photodynamic therapy, have gained
booming development over the past several decades for their attractive non-invasiveness nature, negligible
adverse effects, minimal systemic toxicity, and high spatial selectivity. Phototherapy usually requires
three components: light irradiation, photosensitizers, and molecular oxygen. Photosensitizers can
convert light energy into heat or reactive oxygen species, which can be used in the tumor-killing process.
The direct application of photosensitizers in tumor therapy is restricted by their poor water solubility,
fast clearance, severe toxicity, and low cellular uptake. The encapsulation of photosensitizers into
nanostructures is an attractive strategy to overcome these critical limitations. Poly(glutamic acid) (PGA)
is a kind of poly(amino acid)s containing the repeating units of glutamic acid. PGA has superiority for
cancer treatment because of its good biocompatibility, low immunogenicity, and modulated pH responsiveness.
The hydrophilicity nature of PGA allows the physical entrapment of photosensitizers and anticancer
drugs via the construction of amphiphilic polymers. Moreover, the pendent carboxyl groups of
PGA enable chemical conjugation with therapeutic agents. In this mini-review, we highlight the stateof-
the-art design and fabrication of PGA-based nanoplatforms for phototherapy. We also discuss the
potential challenges and future perspectives of phototherapy, and clinical translation of PGA-based
nanomedicines.
LRRC75A-AS1 Inhibits Chondrogenic Differentiation of Bmscs via Targeting
the Mir-140-3p/Wnt/Β-Catenin Pathway
Authors: Shen Pengfei , Wang Bin , Zheng Chong , Pei Jie , Gan Daofu , Xie Zikang
Published: January 2023

Background:

Bone marrow mesenchymal stem cells (BMSCs) are pluripotent cells with the
ability to differentiate into adipocytes, chondrocytes, and osteoblasts. BMSCs are widely used in regenerative
medicine and cartilage tissue engineering. Role of lncRNA LRRC75A-AS1 (leucine-rich repeat containing
75A antisense RNA 1) in the chondrogenic differentiation of BMSCs was investigated in this study.

Methods:

BMSCs were isolated from rat bone marrow and then identified using flow cytometry. Alcian
blue staining was used to detect chondrogenic differentiation. The effect of LRRC75A-AS1 on chondrogenic
differentiation was assessed by western blot. The downstream target of LRRC75A-AS1 was determined
by dual luciferase activity assay.

Results:

BMSCs were identified with positive CD29 and CD44 staining and negative staining of CD34
and CD45. LRRC75A-AS1 was decreased during the chondrogenic differentiation of BMSCs. Silencing
of LRRC75A-AS1 increased collagen II (COL II), aggrecan and SOX9 and promoted chondrogenic differentiation.
However, over-expression of LRRC75A-AS1 inhibited chondrogenic differentiation. miR-
140-3p was increased during chondrogenic differentiation and interacted with LRRC75A-AS1. miR-140-
3p bind to wnt3a, and inhibition of miR-140-3p up-regulated wnt3a and nuclear β-catenin expression.
Wnt3a and nuclear β-catenin were decreased during chondrogenic differentiation. Inhibition of miR-140-
3p attenuated LRRC75A-AS1 deficiency-induced up-regulation of COL II, aggrecan and SOX9.

Conclusion:

LRRC75A-AS1 suppressed chondrogenic differentiation of BMSCs through down-regulation
of miR-140-3p and up-regulation of the wnt/β-catenin pathway.
Hyperthermophiles: Diversity, Adaptation and Applications
Authors: Alam Masrure , Pandit Baishali
Published: January 2023

Hyperthermophiles are microorganisms that love to grow optimally in
extremely hot environments, with optimum temperatures for growth of 80 °C and
above. Most of the hyperthermophiles are represented by archaea; and only a few
bacteria, such as Geothermobacterium ferrireducens, and members of the genera
Aquifex and Thermotoga have been reported to grow at temperatures closer to 100 °C.
Several archaea, on the other hand, such as Methanopyrus kandleri, Geogemma
barossii, Pyrolobus fumarii, Pyrococcus kukulkanii, Pyrodictium occultum, etc.
isolated from terrestrial hot springs, marine hydrothermal vents, or other hyperthermal
environments have been reported to grow optimally even above the boiling point of
water. The discovery of this astonishing group of microorganisms has not only
provided us with the model systems to study the structural and functional dynamics of
the biomolecules, and to understand the molecular mechanisms of their adaptation to
such high temperature, not even closer to what can be endured by other life forms, but
also have boosted the biotechnological industry to search for new products, particularly
enzymes with unique characteristics, from them. This chapter has exhaustively
reviewed the different hyperthermal environments on Earth’s surface and the
hyperthermophilic microbial diversity in such environments; mechanisms of adaptation
of the hyperthermophiles, especially with regard to the adaptations of the membrane
structures, maintenance of the structures of the nucleic acids and proteins; and their
diverse applications in human welfare. 
Anaerobes
Authors: Pal Arijit , Pal Sekhar
Published: January 2023

Extremophilicity, or the capability to thrive in environmental conditions considered extreme is generally determined from the human perspective. From that point of view, organisms adapted to scarce, or even the absence of molecular oxygen, can be considered as one of the extremophiles, i.e., anaerobes. In this chapter, various aspects of anaerobic microorganisms are addressed, including their different taxa, their phylogenetic distribution, and the environments from where they have been isolated. Since prokaryotic taxonomy is a dynamic process, here we have emphasized the organisms that are validly placed in taxa and have cultured representatives. In this section, Archaea and Bacteria - the two domains are separately discussed. Similar separation is also maintained while discussing mechanisms of adaptation, as far as possible. Since these two domains share certain properties, the subsequent sections are not separated between these two domains. 
Exploring Social Sustainability in the Built Environment
Authors: Goh Cheng Siew , Ting Jia Ning , Bajracharya Arun
Published: January 2023

Following the establishment of the United Nations’ Sustainable Development Goals, sustainability has been given increasing attention in the agenda of the built environment. Sustainability embraces three key elements, i.e., environment, economy and society. However, the social dimension receives the least attention and is largely overlooked compared to the environmental and economic sustainability. To bridge the gap, this paper will examine the various dimensions of social sustainability involved in the built environment and identify perceptions of construction stakeholders towards social sustainability. Social sustainability is closely linked to human well-being, quality of life, and inclusiveness and these are the pivotal factors in ensuring a healthy, safe and resilient built environment. Sustainable buildings require close interactions between humans and buildings to optimize the values of the designed functions. By intertwining with social sustainability, the performance of a sustainable built environment can be significantly improved. This could contribute to the attainment of environmental and economic sustainability by engaging stakeholders since the project's inception. This paper contributes to the body of knowledge of social sustainability and increases stakeholders’ awareness of social sustainability. The research outcomes help promote a more balanced development within the sustainable built environment practice, with more integrated and concerted efforts of developing social sustainability for community benefits.
Political Sentiment Analysis
Authors: Bagaskoro Saktio , Amrozi Imron , Ramadhan Amir Rizqi
Published: January 2023

Kajian ini mengeksplorasi isu kewacanaan elektoral seputar “Jokowi Tiga Periode” yang muncul dan berkembang di Indonesia. Artikel ini mengeksplorasi framming media daring dan analisis sentimen media sosial Twitter terhadap kewacanaan tersebut. Kewacanaan “Jokowi Tiga Periode” ini cukup menarik untuk dielaborasi dan dikerangkai dari perspektif politik karena menekankan unsur personalisasi tokoh sebagai inti wacana. Penelitian menggunakan dua dataset yakni data media online dan data media sosial Twitter dalam kurun waktu yang sama, yakni 1 Maret-31 Juni 2021. Metode yang digunakan dalam kajian ini, yaitu text network analysis, social network analysis, dan natural language processing. Hasil temuan dalam kajian ini menunjukkan bahwa fenomena dorongan perubahan masa jabatan presiden bukan hal baru. Terlebih, analisis terhadap media daring menunjukkan tingginya eksposure pemberitaan terhadap wacana “Jokowi Tiga Periode”. Temuan juga menunjukkan adanya pembagian pemberitaan menjadi empat kluster polarisasi. Dari sisi analisis sentimen, dorongan perubahan masa jabatan presiden melalui wacana “Jokowi Tiga Periode” banyak dinilai oleh pengguna Twitter sebagai hal yang negatif. Ini dibuktikan dengan dominasi sentimen negatif sebanyak 56% dengan mayoritas mengaitkan isu ini dengan konstitusi yang membatasi masa jabatan presiden hanya dua periode.
Social Network Analysis untuk Menilik Kualitas Demokrasi Digital Indonesia
Authors: Hananto Cattleya Ishamina Putri , Dipangga Dhias Dipa , Murningtyas R. A. Annissa Adhi Herawati , Syah Putra Rewinata
Published: January 2023

Media sosial (Twitter) sebagai new public sphere memungkinkan siapa pun untuk membangun wacana dan turut berkontestasi memperebutkan kekuasaan atas ruang “arus utama”. Twitter pada tahun 2018 dan pertengahan 2021 diramaikan oleh dua isu: “Kartu Kuning untuk Jokowi” (repertoar nyata) dan “Jokowi: The King of Lip Service” (repertoar digital murni). Kajian ini bertujuan untuk membandingkan bagaimana bekerjanya contentious politics pada dua repertoar “Kartu Kuning untuk Jokowi” dan “Jokowi: The King of Lip Service” di Twitter sebagai media sosial. Kajian ini juga menginisiasi pemanfaatan Social Network Analysis (SNA) sebagai metode untuk memetakan aktor dalam kedua repertoar. Dua isu tersebut dipilih karena kesamaan aktor yang mencetuskan repertoar, yaitu BEM UI. Repertoar juga sama-sama ditujukan sebagai bentuk kritik kepada Presiden Joko Widodo atas pemerintahannya. Hasil kajian ini melihat perbedaan fundamental dari kedua isu tersebut, yaitu repertoar “nyata” dan repertoar digital murni, dimana contentious politics menggunakan repertoar “nyata” bertahan lebih lama daripada repertoar digital “murni”.
BIOANALYTICAL METHOD FOR TERIFLUNOMIDE ESTIMATION BY HPLC
Authors: GURAV POOJA , DAMLE MRINALINI
Published: January 2023

Objective: The aim of this study was to develop and validate simple and economical HPLC method for estimation of Teriflunomide in human plasma.
Methods: HPLC method was developed using AgilentEclipse XBD C8 (4.6 mm×150 mm) as stationary phase and mobile phase used was ammonium acetate buffer: methanol (40: 60 v/v). The detection was carried at wavelength 294 nm. A simple protein precipitation technique was used with acetonitrile as protein precipitating agent and Paliperidone palmitate was chosen as internal standard. Validation was carried out as per USFDA guidelines for bio-analytical method.
Results: The linearity range set was 10–60 μg/ml. The value of regression coefficient was found to be 0.9953. Retention time for Teriflunomide was found to be 4.8 min. The developed method was validated for various parameters such as specificity, linearity, accuracy, precision, recovery, and stability.
Conclusion: The developed method is simple, rapid, and economical for estimation of Teriflunomide in human plasma.
COST CONSEQUENCE ANALYSIS OF DIABETIC NEPHROPATHY MANAGEMENT IN A TERTIARY CARE HOSPITAL
Authors: KURIEN SARA , R MANOHAR V , KUMAR K SHARATH , RAVINDRAN ARUN
Published: January 2023

Objective: The objective of the study was to assess the overall costs incurred to patients with diabetic nephropathy (DN) and to disclose the elements that could affect them.
Methods: Two-year retrospective, observational study using hospital database of a tertiary care center in Mangalore. Outcomes were assessed based on the survival of patients, length of hospital stay, coexistence of risk factors, and comorbidities. Severity was identified through staging of the disease; costs and clinical outcomes assessed through the cost consequence analysis.
Results: Of the 156 patients who met the diagnostic criteria, it was noticed that demographic age factor for DN was declining and the minimum duration to develop DN was seen to be as less as 1–5 years. In spite of having ample evidence that angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) control the progression of disease, not many doctors were inclined to follow. A study showed that patients of DN with chronic kidney disease (CKD) spent more and patients with CKD and end-stage renal disease (ESRD) spent double than those with CKD alone.
Conclusion: Overall costs in treating 156 patients of DN amounted to 10 lakh INR and the major determinant was the cost of investigations, unlike what was expected of the drug prices.
ADVERSE DRUG REACTIONS PATTERN IN OUTPATIENTS AND INPATIENTS OF A TERTIARY CARE HOSPITAL FROM NORTHERN INDIA
Authors: IMRAN MOHAMMAD , BHARDWAJ ANU , KHARE NEERAJ , SINGH ABHISHEK
Published: January 2023

Aim: Adverse drug reaction (ADR) reporting and monitoring activities are of vital importance for patient safety. It is a predominant ubiquitous and preventable clinical issue. This study was conducted to assess the ADR reporting in various departments.
Methods: Standard ADR reporting forms were filled up by healthcare workers for patients from January 2020 to December 2021 for different departments. The causality appraisal of the ADRs was finished utilizing WHO-UMC causality evaluation scale. Seriousness of the recognized ADRs was evaluated at various levels, going somewhere in the range of 1–7 utilizing altered Hartwig-Siegel Scale.
Results: The frequency of ADRs was higher among females (60.4%) when contrasted with guys (39.6%). The causality appraisal of ADRs cases showed that 85.7% of ADRs were “likely” and 51.2% of patients were sorted as “moderate” on seriousness evaluation of ADRs. The further examination of ADRs cases showed that 36.4% of ADRs cases (79/217) were “medical admissions due to ADR” and 63.6% of ADRs cases (138/217) were “ADRs happened in hospitalized patients.”
Conclusion: This study finds that ADRs are frequent in this health center showing emergency clinic and this study would give an understanding into the example of ADRs in a tertiary medical services place and may assist with expanding mindfulness for additional pharmacovigilance studies.
PROSPECTIVE STUDY OF CLINICAL OUTCOME OF FRACTURE SHAFT FEMUR IN CHILDREN TREATED WITH TITANIUM ELASTIC NAILING: OUR RESULTS
Authors: SHELENDRA SAIYAM , KISHOR UIKEY , SHAILENDRA CHOUHAN
Published: January 2023

Introduction: Femur fracture in children between 5 and 15 years is a common injury with a variety of operative and non-operative management options. There remains debate as to the optimal treatment for a given patient and fracture. Our aim was to assess functional outcome of a large number of patients after their femur fractures with a titanium elastic nailing (TEN).
Methods: This was a prospective randomized study comprised 50 patients with displaced diaphyseal femur fractures treated with TEN. Two nails were used in fracture. The patients were followed up at 2nd week, 1 month, 3 months, and 6 month after surgery. Results were evaluated by flynn’s scoring criteria at each follow-up visit.
Results: At the end of 6 months, out of 50 patients, excellent result was achieved in 45 patients (90%) and good in five patients (10%). No poor outcome seen. Intramedullary fixation by Tens is an effective treatment of fracture of femur in properly selected patients of the 5–15 years age group.
Conclusion: The treatment with femoral shaft fracture in children between the age group of 5–15 years by titanium elastic nail is ideal as it hastens fracture union, reduce rate of mal union, shortening, and allow early rehabilitation.
ANXIOGENIC EFFECT OF AN ATYPICAL ANTIPSYCHOTIC, OLANZAPINE IN PRE-CLINICAL MODELS
Authors: M JAYARAJ , VERNON D’SOUZA FLOYD
Published: January 2023

Introduction: Atypical antipsychotics, such as olanzapine, act on multiple neurotransmitter pathways and produce complex central nervous system effects. Pre-clinical and clinical studies conducted in the past, to study their effects on anxiety, have come up with confusing and contradictory observations. Some studies have even indicated anxiogenic effect of these novel drugs. These observations are significant, because anxiety symptoms are known to be present in about 65% of schizophrenia patients. Any possible anxiogenic effect by one of the extensively used antipsychotic can have adverse impact on these patients. Hence, this study was undertaken with the aim of evaluating olanzapine for its effects on anxiety, in preclinical models.
Methods: Rats of either sex weighing between 150 and 300 g were placed into three groups of six each. For 10 days, oral doses of the test drug (olanzapine 2 mg/kg), the control drug (distilled water), and the standard drug (diazepam 1 mg/kg) were given. The animals were taken for the elevated plus maze (EPM) and light dark arena (LDA) screening tests on the 10th day, 1 h after the compounds were administered.
Results: Olanzapine treatment significantly reduced the amount of time that animals spent in open arms (p<0.05) of the EPM, and highly lighted compartments (p<0.05) of LDA, as compared to animals receiving control treatment, showing a significant anxiogenic impact.
Conclusions: Olanzapine has exhibited potential to produce anxiogenic effect in preclinical models. Hence, it is suggested to use olanzapine with caution in patients of schizophrenia with anxiety symptoms.
“Abrazos, no muros”: entre la fronterización y la resistencia a la frontera en el límite México-Estados Unidos
Authors: Oliveras González Xavier
Published: January 2023

El artículo tiene por objetivo dar cuenta del ensamblaje y la tensión entre dos procesos opuestos, la fronterización y la resistencia a la fronterización. Con el fin de evitar la representación de ambos procesos, se aplica un enfoque teórico-metodológico inspirado en la teoría no-representacional. Para lograrlo se analiza un caso de estudio: “Abrazos, no muros”, una acción de resistencia realizada en el límite fronterizo entre México y Estados Unidos. El análisis del despliegue de ese evento, es decir, de las interacciones temporales entre múltiples cuerpos, objetos, prácticas, emociones, lugares y terrenos, muestra que está sujeto a una intensa representación y regulación fronteriza, a la vez que emergen vías de subversión imprevistas e incontrolables.
Migración africana en situación de espera: nuevo alcance y dimensión de la contención migratoria en México
Authors: Miranda Bruno
Published: January 2023

En 2019, las personas migrantes transcontinentales provenientes de varias regiones de África salieron a la luz pública en México a causa de los tiempos de espera a los que fueron sometidas en la frontera sur del país. Desde entonces, el gobierno mexicano ha aplicado mecanismos burocráticos para contener la migración de tránsito, que se sumaron a la implementación de listas de espera en la frontera con Estados Unidos. En este artículo examino los efectos de los tiempos de espera en las fronteras mexicanas al sur (Tapachula) y al norte (Tijuana) entre 2019 y 2021. Los hallazgos ratifican que la espera fuerza el tránsito irregularizado y causa mayor exposición de migrantes africanos a la violencia estatal. Como resultado, las prácticas de contención migratoria en México finalmente alcanzaron a las poblaciones transcontinentales y se ampliaron de la dimensión espacial a la espacio-temporal.
Effect of Bamboo Fibre on the Properties of Pavement Quality Concrete
Authors: Ganaie Javid Iqbal , Singh Navdeep
Published: January 2023

Abstract: In this report we discusses about the settlement of rigid pavements utilizing bamboo fibre. The study aims to examine the practicability of using bamboo as a fibre in pavement quality concrete with 0.38 water/binder ratios. This report presents the detailed amount of fibre used ranging from 0 to 1.5% with a variation of 0.5% on trial basis. Since the concrete used in pavements requires high strength because of the high volume of traffic so the concrete has been made using silica fume with 3% by weight of cementitious material and which adds to the longer life of fibre. Also using mineral admixtures makes concrete less permeable and less the permeability more durable the concrete is. Adding bamboo fibre up to 0.5% the compressive strength gets increased and beyond 0.5% of fibre addition the strength starts decreasing and as we keep on mounting the fibre percentage up to 1.5% the flexural strength also rises
Decentralized Chat Application using Blockchain Technology
Authors: Khalkar Keshav
Published: January 2023

Abstract: Decentralized application make use of peer-to-peer networks, this ensures that no network failure can occur due to central node failure. Blockchain serves as an immutable ledger which allows messaging to take place in a decentralized manner. A decentralized application for communication and resource sharing is need in today’s world, where keeping data on a centralized server can be risky and costly experience. With the help of various consensus, we can implement different ways to share resources and communicate. Together with Blockchain and Decentralized Applications, we can create a secure and reliable messaging application that overcomes the drawbacks of traditional messaging applications.
Analysis of Academic Emotional Changes and Structural Topic Model(STM) in Earth Science Subject Class Using Virtual Reality(VR) Contents
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Woo Kyum
Published: January 2023

Objectives The purpose of this study was to investigate the effect on learner’s academic emotion by using virtual reality (VR) content in the Earth science class, and to analyze their correlation by analyzing the structural topic model (STM) of the students' academic emotional response.
Methods For this purpose, a class was conducted using virtual reality (VR) contents in the earth science subject for 54 science high school students. In order to measure changes in academic emotion, pre- and post- academic emotion tests were performed and For the structural topic model (STM) analysis of students' academic emotional responses, students' responses were freely expressed in text. The collected data were analyzed by paired t-test and text mining structural topic model (STM) analysis.
Results As a result of the pre- and post- paired t-test on academic emotions, the application of virtual reality (VR) content to Earth science subjects had a statistically significant difference in academic emotions and Among academic emotions, there was a statistically significant difference in increasing positive emotions and decreasing negative emotions. In addition, as a result of structural topic model (STM) analysis of academic emotions, when positive emotions were increased, the probability of topic expression for “geological unit learning through VR panorama” was statistically significantly higher, When negative emotions were reduced, it was found that the probability of topic expression for “understanding through experience,” “learning of geological units through VR panorama”, and “learning of geological structures” was statistically significantly improved.
Conclusions Based on these results, the application of virtual reality (VR) content to earth science subjects can improve positive emotions and reduce negative emotions among students' academic emotions. In addition, as shown in the structural topic model results, the improvement of topic expression probability for geological unit learning due to changes in academic sentiment suggests that it can be used as a teaching/learning method in earth science subject classes.
Competency to foster future talents recognized by college students: Focusing on the case of D University
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Yang Yun Jung , Shim Tae Eun
Published: January 2023

Objectives This study aims to examine what competency types college students need to produce as future talents in a situation where society is rapidly changing, and to understand the characteristics and implications of each recognition type.
Methods The Q methodology was used to identify the competencies that future talents should have. In addition, 38 P samples interested in career and employment preparation and competency were used. In order to classify Q, 104 students received a response saying, “What is the competency for fostering future talent?” and 148 responses were derived by combining the literature research items. In addition, in order to specify the students' thoughts, five college students were organized through FGI group interviews, and the final 40 statements were composed with help from five employment and competency research experts. For the Q factor analysis, correlation and major factor analysis methods were used using the QUANL program.
Results The competencies necessary for fostering future talent that college students think of were derived into four types. Type 1 is a ‘self-development type using digital literacy’ by emphasizing the importance of competency for various information acquisition through digital while adapting to rapid social changes. Type 2 is a ‘flexible thinking-based information acquisition reinforcement type’ with an open attitude and flexibility in environmental change, and Type 3 is a ‘critical thinking reinforcement type for promoting social change’ that maintains objectivity and emphasizes constructive critical ability. Finally, Type 4 was classified into a ‘type of communication reinforcement for convergent thinking’ that recognizes diversity and differs and communicates appropriately based on it.
Conclusions It is thought that if students recognize and cultivate the necessary competencies on their own, rather than presenting and acquiring the competencies needed by society and companies as education and school policies, they will become highly adaptable talents to the future society. If the curriculum and comparison programs for this purpose are supplemented, it will be possible to foster talent required by the future society.
A Case Study on ESR Project Participation Experience of University Students: Focused on ‘Urban Innovation School in Busan’
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Jung Minyoung , Lee Sangsu , Bae Gana , Baek Seungwon , Jung Insook
Published: January 2023

Objectives This study aims to investigate the learning of university students who had Education for Social Responsibility practice experiences participating in Urban Innovation School in Busan project through a descriptive case study. The learning of research participants who practiced ESR was analyzed by a qualitative method to explore implications for ESR research, education, and practice. Finally, this study aims to identify the meaning and value of ESR.
Methods In order to achieve the research purpose, Urban Innovation School in Busan project was selected as a case to be analyzed. In this study, a descriptive case study was employed. The results of this study were derived based on the qualitative analysis of the in-depth interview data, and additionally, the research team performed participant observation and analysis of document data on the research participants.
Results In order to achieve research objectives and derive research results on research problems, this study analyzed in detail the learning that research participants experienced in the process of practicing ESR based on a descriptive case study. The results of this study were as follows. First, the participants experienced independent learning and growth through the application of knowledge and skills by practicing ESR. Second, the participants experienced a change of consciousness about social issues by practicing ESR. Third, it was found that the unstructured problem-solving ability of the participants was increased by practicing ESR. Fourth, the perception of influence of individuals on society was improved.
Conclusions This study confirms that the experience of ESR practice and participation can promote the continuous growth of members of society and the realization of self-actualization. It was confirmed that the university's ESR practice project is an opportunity to seek solutions to various and complex social problems that cannot be predicted in modern and future society.
A Study on the Perception of Educational Members on the University Innovation Support Project: Focusing on A University
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lim Hyunbin , Ha ChaeHyun
Published: January 2023

Objectives This study is to investigate the business performance of A university members in the Jeonlabuk-do region and their perceptions for the next project performance for the University Innovation Support Project to build basic data for future University Innovation Support Project ideas.
Methods We analyzed data obtained from 118 respondent using a series of frequency analyses, Importance- Performance analyses and t-test.
Results As a result of the member satisfaction and performance perception survey on the university innovation support project, the staff group showed higher satisfaction and performance perception than the faculty group participating in the project. We found that strategic efforts were needed to balance the equal distribution the performance and perception of members.
Conclusions Through this study, we demonstrated that a strategy for innovation based on the university's mid- to long-term development plan is needed separately, and that this innovation strategy is to increase interest and understanding of the business while respecting the diversity of members who are education providers.
A Comparative Study on Ecological Worldview of Elementary School Students and Pre-service Elementary Teachers
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Park Hyeonjin , Ko Hyunkook , Kwon Dongtaik
Published: January 2023

Objectives The purpose of this study is to investigate the ecological worldview of elementary school students, who are the future society’s main pillars, along with pre-service elementary teachers who will educate them. For this study, a questionnaire that has been verified by many people and is widely used was used.
Methods The subjects of this study were 352 elementary school students and 92 pre-service elementary teachers. To elementary school students, the questionnaire ‘NEP Scale for Elementary School Students in Korea’ was printed and distributed. In addition, ‘The New Ecological Paradigm Scale’ was distributed online to pre-service elementary teachers. A total 336 questionnaires for elementary school students and 92 questionnaires for pre-service elementary teachers were collected. The data was analyzed using the SPSS statistical program.
Results The results of this study are as follows. First, there was no statistically significant difference in the average values of the ecological worldview of elementary school students and pre-service elementary teachers. However, the average value of elementary school students in two sub-factors was higher than the average value of pre-service teachers. Second, as a result of analyzing the ecological worldview by background variables of elementary school students, there was no significant difference in average values according to grade level. However, the average values of some of the sub-factors showed significant differences according to gender. Third, as a result of analyzing the ecological worldview by background variables of pre-service elementary teachers, there was no significant difference in average values according to grade level. But there was a significant difference in the overall average value of ecological worldview and some of its sub-factors according to gender.
Conclusions The conclusions of this study are as follows. First, an individual's ecological beliefs may be independent of age. Therefore, instructors should consider these characteristics when designing education related to ecological worldview. Second, children and adults may have different processes for constructing an ecological worldview. Thus, pre-service teachers and teachers must understand children’s ecological worldview. Third, the ecological worldview of elementary school students and pre-service teachers differ according to gender. Therefore, efforts are needed to clarify the cause from various aspects.