bluuebunny/crossref_metadata_2025 huggingface dataset:
Combined Effect of Sarcopenia and Systemic Inflammation on Survival in Patients with Advanced Stage Cancer Treated with Immunotherapy
Authors: Bilen Mehmet Asim , Martini Dylan J. , Liu Yuan , Shabto Julie M. , Brown Jacqueline T. , Williams Milton , Khan Amir I. , Speak Alexandra , Lewis Colleen , Collins Hannah , Kissick Haydn T. , Carthon Bradley C. , Akce Mehmet , Shaib Walid L. , Alese Olatunji B. , Pillai Rathi N. , Steuer Conor E. , Wu Christina S. , Lawson David H. , Kudchadkar Ragini R. , El-Rayes Bassel F. , Ramalingam Suresh S. , Owonikoko Taofeek K. , Harvey R. Donald , Master Viraj A.
Published: December 2019

Background

Sarcopenia and inflammation have been associated with poor survival in patients with cancer. We explored the combined effects of these variables on survival in patients with cancer treated with immunotherapy.

Methods

We performed a retrospective review of 90 patients enrolled on immunotherapy-based phase I clinical trials at Emory University from 2009 to 2017. Baseline neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, and platelet-to-lymphocyte ratio (PLR) were used as surrogates of inflammation. The skeletal muscle index (SMI) was derived from the skeletal muscle density calculated from baseline abdominal computed tomography images. Optimal cutoffs for continuous inflammation biomarkers and SMI were determined by bias-adjusted log-rank test. A four-level risk stratification was used to create low-risk (PLR <242 and nonsarcopenic), intermediate-risk (PLR <242 and sarcopenic), high-risk (PLR ≥242 and nonsarcopenic), and very-high-risk (PLR ≥242 and sarcopenic) groups with subsequent association with survival.

Results

Most patients (59%) were male, and the most common cancers were melanoma (33%) and gastrointestinal (22%). Very high-risk, high-risk, and intermediate-risk patients had significantly shorter overall survival (hazard ratio [HR], 8.46; 95% confidence interval [CI], 2.65–27.01; p < .001; HR, 5.32; CI, 1.96–14.43; p = .001; and HR, 4.01; CI, 1.66–9.68; p = .002, respectively) and progression-free survival (HR, 12.29; CI, 5.15–29.32; p < .001; HR, 3.51; CI, 1.37–9.02; p = .009; and HR, 2.14; CI, 1.12–4.10; p = .022, respectively) compared with low-risk patients.

Conclusion

Baseline sarcopenia and elevated inflammatory biomarkers may have a combined effect on decreasing survival in immunotherapy-treated patients in phase I trials. These data may be immediately applicable for medical oncologists for the risk stratification of patients beginning immunotherapeutic agents.
KAHRAMANMARAŞ TEKERLEMELERİNDEKİ GİZEMLİ KELİMELER
Authors: KALAYCI Ünal
Published: December 2019

Anonim halk
edebiyatı içerisinde yer alan tekerlemeler, hem bağımsız bir türdür hem de masallardan
çocuk sayışmacalarına kadar çok farklı edebî türler içerisinde kullanılmaktadır.
Ahenk unsurlarının ön planda olduğu bu türde dikkati çeken hususlardan biri de anlamı
ilk bakışta bilinmeyen çok sayıda kelimenin kullanılmasıdır:

 

a. Hazara huzara

Göz atanın
gözü kızara

 

b. Dırın dırın Andırın

İki dükkân
bir fırın

 

c. Huuu dilik bidilik

Saçlar
başlar kıvırcık

Sen bu
oyundan çık

 

d. Avrat var
zamuru zort

Avrat var çepeli mürt

Avrat var
hazreti mülk

 

Örneklerde
de görüldüğü gibi “hazara huzara”, “dırın dırın”, “dilik bidilik”, “zamuru
zort”, “çepeli mürt” kelimeleri günlük kullanımda yok gibidir. Tekerlemelerde
kullanılan bu tür kelimelerin anlamları ya da görevleri yok mudur? Çalışmanın
amacı üzerinde pek düşünülmeyen tekerlemelerdeki bu tarz gizemli kelimelere
dikkat çekerek o kelimelerin anlam ve görevlerini sorgulamaktır.

 

Çalışmanın
ilk aşamasında AB projesi kapsamında hazırlanan “Tek Tek Tekerleme/
Kahramanmaraş Tekerlemeleri” adlı kitap taranarak anlamları ilk bakışta çözümlenemeyen
kelimeler araştırma konusu olarak seçilmiştir. İkinci aşamada Kahramanmaraşlılarla
görüşme yapılarak tekerlemelerde geçen gizemli kelimelerin anlamları çözülmeye
çalışılmıştır. Üçüncü aşamada yapılan görüşmelerden ve konuyla ilgili sözlüklerden
hareketle bu kelimelerin anlamları ortaya çıkarılmış, anlamları bulunamayanların
hangi amaçla kullanıldıkları tespit edilmiştir.
A lexical learning task for English and Italian participants v1
Authors: Valeria Marinelli Chiara , Zoccolotti Pierluigi , Romani Cristina
Published: December 2019

“Lexical learning” is the ability to set up stable and accurate mental representations of words in the lexicon (Di Betta & Romani, 2006). The task allow to test the ability of Italian and English subjects to learn written pseudo-words in an explicit paired associate learning task, through corrective feedback. For more details see Marinelli, Zoccolotti & Romani (in revision).
Öğretim Üyelerinin Öğrenme Ortamlarında Yeni Teknolojileri Kullanma Düzeyinin Belirlenmesi
Authors: Hava Kevser
Published: December 2019

Bu çalışmanın amacı öğretim üyelerinin öğrenme ortamlarında yeni teknolojileri kullanma düzeyinin belirlenmesidir. Tarama modeli çerçevesinde gerçekleştirilen çalışmaya, 2017-2018 akademik yılında Türkiye’nin 9 farklı üniversitesinde görev yapan 112 öğretim üyesi katılmıştır. Veri toplama aracı olarak araştırmacı tarafından uyarlanan “öğrenme ortamlarında yeni teknolojiler” anketi kullanılmıştır. Araştırma sonuçlarına göre öğretim üyelerinin büyük bir çoğunluğu uyarlanabilir sistemler, bağlam duyarlı ortamlar, elektronik gelişim dosyaları ve RSS beslemeleri hakkında bilgi sahibi değildirler. Öğretim üyelerinin yaklaşık yarısından fazlası öğrenme ortamlarında sanal gerçeklik, giyilebilir teknolojiler, dijital ve çok kullanıcılı oyunlar ve arttırılmış gerçeklik teknolojilerini hiç kullanmadıklarını belirtmişlerdir. Buna ek olarak az sayıda öğretim üyesinin kaynakça düzenleme ve yönetim araçlarını, dijital ve çok kullanıcılı oyunları ve sanal gerçeklik teknolojilerini yalnızca bir kez; blog, e-kitapları, tablet bilgisayarı ve açık öğrenme kaynaklarını nadiren; anlık mesajlaşma servislerini, e-kitapları ve sosyal medya araçlarını ise ihtiyaç duyduklarını anda kullandıkları belirlenmiştir. Az sayıda öğretim üyesi sanal gerçeklik, arttırılmış gerçeklik ve web konferans uygulamalarını ilerleyen yıllarda öğretim süreçlerinde kullanabileceklerini düşünmektedirler. Yeni teknolojilerin çalışılan kurumda mevcut olması, meslektaşlar aracılıyla haberdar olma, konferanslar, öğrencilerin talep etmesi ve kişisel merak, öğretim üyelerinin yeni teknolojileri keşfetmelerini sağlayan önemli fırsatlardır.
Apresentação: (Re)pensando os arquivos literários
Authors: Medeiros Elen de , Rodrigues Leandro Garcia , Mendes Moema Rodrigues Brandão , Tocco Valéria
Published: December 2019

.
Teor de Lactose em Iogurtes Naturais e Leites Fermentados
Authors: Rosa Fernanda Dos Santos da , Alves Márcia Keller
Published: December 2019

A lactose, dissacarídeo presente no leite, tem papel fundamental na fabricação de leites fermentados, já que é o carboidrato utilizado como substrato pelas bactérias, que promovem a fermentação láctica, obtendo assim um produto com menor teor de carboidrato. O presente estudo experimental teve como objetivo avaliar o teor de lactose de iogurtes e leites fermentados. A análise foi realizada no Laboratório de Ciências da Faculdade Nossa Senhora de Fátima, na cidade de Caxias do Sul, Rio Grande do Sul, seguindo a metodologia descrita pelo Instituto Adolfo Lutz. De forma complementar, foram analisados: teor de ácido lático, acidez em graus Dornic e presença de amido. Os resultados encontrados foram comparados com os parâmetros exigidos pela legislação em vigor. As amostras de iogurte apresentaram maior quantidade de lactose em relação aos leites fermentados, com variação entre 0,28 g a 0,40 g em 100 mL-1 e 0,19 g a 0,26 g em 100 mL-1 de produto, respectivamente. A acidez Dornic variou de 78 ºD a 102,5 ºD entre os iogurtes e de 70,5 ºD a 129,5 ºD entre as amostras de leite fermentado, enquanto que a acidez em ácido lático por 100 mL variou de 0,98 g a 1,14 g para iogurtes e de 0,77 g a 1,43 g para leites fermentados. Não foi encontrado amido em nenhuma das amostras. Conclui-se que os parâmetros avaliados se encontraram em conformidade com a legislação brasileira vigente. Por fim, os leites fermentados podem ser classificados como alimentos de baixo teor de lactose.Palavras-chave: Iogurte. Lactose. Fermentação. Ácido Láctico.AbstractThe lactose, disaccharide present in milk, plays a fundamental role in the production of cultured milk, since it is the carbohydrate used as bythe bacteria that promote lactic fermentation, thus obtaining a product with lower carbohydrate content. The present study aimed to evaluatethe lactose content of cultured yogurts and milk. This was an experimental study carried out in the Laboratory of Sciences of Nossa Senhora de Fátima College, in the city of Caxias do Sul, RS. Lactose content, Dornic acidity and the presence of starch in yogurts and industrialized cultured milk were analyzed following the methodology described by Adolfo Lutz Institute. The results were compared with the parameters required by the legislation in force. Yogurt samples showed a higher amount of lactose than cultured milk, ranging from 0.28 g to 0.40g in 100 mL-1 and 0.19 g to 0.26 g in 100 mL-1 of product, respectively. The Dornic acidity ranged from 78 to 102.5 ºD among yogurts and from 70.5 to 129.5 ºD among cultured milk samples, whereas the acidity in lactic acid per 100 mL ranged from 0.98 to 1.14g for yogurts and from 0.77 to 1.43 g for cultured milk. No starch was found in any of the samples. It is concluded that the evaluated parameters were in accordance with the Brazilian legislation in force. Finally, cultured milk can be classified as low lactose food.Keywords: Yogurt. Lactose. Fermentation. Lactic Acid.
Desenvolvimento do Sistema de Plantio Direto no Brasil: Histórico, Implantação e Culturas Utilizadas
Authors: Fernandes Carlos Henrique Dos Santos , Tejo Débora Perdigão , Arruda Klever Márcio Antunes
Published: December 2019

O Sistema de Plantio Direto foi introduzido no Brasil no final da década de 1960, contudo, esse já vinha sendo empregado nos Estados Unidos desde 1950, demonstrando grandes benefícios. O objetivo do trabalho foi abordar o plantio direto no Brasil, expondo suas características e seus benefícios para a conservação do solo. É imprescindível o conhecimento técnico para obter sucesso na implantação deste sistema, e se destacam cuidados com o solo, como identificação do tipo de solo, eliminação de camadas compactadas, nivelamento, correção de acidez, entre outros. A utilização de plantas de cobertura merece atenção, pois proporciona proteção das camadas superiores do solo, evitando a erosão. Dessa forma, devem ser priorizadas as plantas de rápido desenvolvimento, visto que quanto mais rápido o desenvolvimento da espécie, mais rápido serão proporcionados os benefícios físicos ao solo. Além disso, trata-se de uma prática viável de se empregar em áreas de cultivo agrícola. Em conjunto com a adoção do método do plantio direto se pode empregar a prática de rotação de cultura, que também se mostra eficiente no processo de conservação dos recursos naturais, com destaque para o solo. Conclui-se que desde sua implantação, o sistema de plantio direto vem trazendo inúmeras vantagens para a conservação do solo, melhorando a qualidade, aumentando a rentabilidade das áreas de exploração agrícola. Palavras-chave: Agricultura Conservacionista. Conservação do Solo. Manejo do Solo. AbstractThe No-tillage Farming System was introduced in Brazil in the late 1960s, but it had been used in the United States since 1950, showing great benefits. The objective of this work was to address no - tillage in Brazil, exposing its characteristics and its benefits to soil conservation. It is essential the technical knowledge to be successful in the implementation of this system, among them stand out soil care, such as identification of soil type, elimination of compacted layers, leveling, acidity correction, among others. The use of cover plants deserves attention, as it provides protection of the soil upper layers, avoiding erosion. Therefore, fast-growing plants should be prioritized, since the faster the development of the species, the faster the physical benefits will be provided to the soil. In addition, it is a viable practice to employ in agricultural areas. In conjunction with the adoption of the no-tillage method, it is possible to use the crop rotation practice, which is also efficient in the conservation process of natural resources, especially soil. It is concluded that since its implementation, the no-tillage system has brought innumerable advantages to soil conservation, improving its quality, increasing the farm areas profitability. Keywords: Conservationist Agriculture. Soil Conservation. Management.
Creating consumer protection law vs. responsible borrowing on the consumer loan market
Authors: Borys Grażyna , Manacka Renata
Published: December 2019

Responsible borrowing means a thorough reflection on the need to become indebted, full transfer of true information affecting creditworthiness, comprehensive analysis of the credit agreement, and refraining from avoiding the repayment of loan obligations. The main purpose of the article is to verify the hypothesis that Polish legislators make only the lenders fully responsible for excessive borrowing on the consumer loan market. The following research methods were used: critical analysis of the subject literature and economic analysis of the respective legal provisions. On the basis of the analyses conducted, areas were identified in which the legislator should use the appropriate legal instruments stimulating responsible borrowing. Among them the following were listed: the consumer's obligation to prove the absence of overdue payments and the consumer’s notification of becoming acquainted with the terms of the loan agreement.
The use of stakeholder analysis in assessing the effectiveness of selected functions of the Gdańsk Science and Technology Park
Authors: Susmarski Sebastian
Published: December 2019

Stakeholder analysis provides relevant information about the organization’s impact on the environment and the environment’s impact on the organization. These relationships are gaining importance in investment activities, especially in relation to projects that are partly or fully financed from public funds. Stakeholder analysis is therefore a key tool for project managers providing them with knowledge on the best communication strategy with stakeholders that can lead to management of relationships with stakeholders. The aim of the article is to indicate how much the balance of social benefits and costs perceived by stakeholders regarding the expansion of an innovation centre, the Gdańsk Science and Technology Park (GSTP), contributes to the increase in the value of this project. The study also has partial goals established: the effectiveness of implementing by the GSTP the function of increasing cooperation with universities and the industry in conducting experimental research and subsequently translating these effects into practical applications from the point of view of companies and residents. The key element of the research was to identify the needs of particular groups of stakeholders in the context of choosing methods of communicating with them. The study used a survey conducted among stakeholders of the GSTP.
Glosa do wyroku Sądu Najwyższego z dnia 28 lutego 2017 r. (I CSK 127/16, LEX nr 2297403)
Authors: Dumkiewicz Małgorzata
Published: December 2019

The commented judgement concerns significant legal issue, namely the consequences of ineffective lapse of a six-month time limit for notification of share capital increase in a limited liability company, in respect of in-kind contributions in the form of real estate (property), that have been made before that time limit. Article 256 § 3 of the Code of Commercial Companies refers to respective application of Article 169 of the Code of Commercial Companies in respect to the registration of an amendment to the company deed. In the commented judgement, the Supreme Court explained how the above-mentioned reference should be interpreted in the case of the increase of share capital in a limited liability company for an in-kind contributions in the form of the share in the ownership of a property.
Glosa do wyroku Sądu Apelacyjnego w Krakowie z dnia 24 września 2015 r. (II AKa 97/15)
Authors: Kosowski Jakub
Published: December 2019

The gloss refers to the issue of protocolling in a criminal trial. The author analyzes the current case law in the discussed scope, pointing to the current assumptions of conducting this procedural act. In this respect, doubts arise due to the disability of this method of protocolling, which can be eliminated by means of the e-protocol. In the last part of the study, the author points out the practical problems related to the implementation of the e-protocol, as well as evaluates the proposed regulations of the Ministry of Justice, which are to simplify the penal procedure by increasing the efficiency of work with the e-protocol.
ESTUDO DA TOXICIDADE DO GLIFOSATO NA GERMINAÇÃO DE COUVE E RABANETE
Authors: Villa F. B. , Monteiro J. O. F. , Godoy G. B. , Souza D. S. S. , Ramos J. L. , Dias A. B. , Portela A. L. R. , Cristiano G. A. , Godoi I. R. G. , Gabriel L. , Volpe M. C. , Neves V. D. D. , Sebastiani R. , Pelegrini R. T.
Published: December 2019

O presente trabalho teve como objetivo avaliar os efeitos tóxicos do glifosato (N-(fosfonometil)-glicina), um herbicida muito utilizado na agricultura brasileira, como agente estressor, através de uma metodologia de avaliação de toxicidade crônica e aguda nas sementes de couve (Brassica oleracea L.) e rabanete (Raphanus sativus L.). A metodologia escolhida possibilitou a análise dos parâmetros CENO (Concentração de Efeito Não Observável), CEO (Concentração de Efeito Observável) e CE50 (Concentração Efetiva) para cada uma das espécies. Tratando-se do rabanete, foi observado que o CENO aparecia em 1 mg.L-1 de agente estressor, o CEO em 2 mg.L-1 e o CE50 em aproximadamente 7 mg.L-1. Para a couve, observou-se o aparecimento do CENO em 16 mg.L-1, o CEO em 18 mg.L-1 e o CE50 entre 14 e 15 mg.L-1. Foi possível ter, através do estudo, um alto controle do valor de pH (7,0 para o rabanete e 7,5 para a couve), elevada sensibilidade e baixo custo se comparado a outros testes de toxicidade.
ESTUDOS DA TOXICIDADE DO ALUMÍNIO EM VALORES DE pH 7,0 E 7,5 PARA BRASSICA OLERACEA L. E RAPHANUS SATIVUS L.
Authors: Gabriel L. , Volpe M. C. , Cristiano G. A. , Neves V. D. D. , Souza D. S. S. , Ramos J. L. , Portela A. L. R. , Dias A. B. , Villa F. B. , Godoy G. B. , Godoi I. R. G. , Monteiro J. O. F. , Sebastiani R. , Pelegrini R. T.
Published: December 2019

A toxicidade do alumínio tem sido verificada somente em valores de pH abaixo de 5,5 devido a solubilidade dos íons Al3+ que ocorre em meio ácido. Este trabalho teve o objetivo de estudar a toxicidade do alumínio em valores de pH 7,0 para a espécie Raphanus sativus L. (rabanete) e 7,5 para a Brassica oleracea L. (couve) com a finalidade de verificar se em tais valores de pH o alumínio não apresentava efeitos deletérios observáveis. Foi utilizada uma metodologia em que o meio de cultivo continha sementes como organismos testes e um rígido controle dos valores de pH. Os ensaios toxicológicos empregavam concentrações otimizadas de macro e micronutrientes necessários ao desenvolvimento das plântulas. Com o estudo foi possível verificar elevada Toxicidades Aguda e Crônica dos íons Al3+ em valores de pH 7,0 e 7,5 para as plantas estudadas, comprovando que os efeitos tóxicos do alumínio podem ser verificados também em meio de cultivo com valores de pH neutro e ligeiramente básico.
PRODUÇÃO DE MILHO EM DIFERENTES PROFUNDIDADES DE PLANTIO
Authors: Silva A. P. F. , Da Costa D. J. , Vicente D. L. C. , Da Silva A. A. , Pereira C. S.
Published: December 2019

O milho (Zea mays L.) é um dos cereais mais utilizados e relevantes, devido às suas propriedades nutricionais, composição química e diversidade de utilização, tanto na alimentação humana quanto animal. Com as constantes inovações no setor agropecuário, buscando-se uma melhor produção e redução de custos, surge um crescente interesse por prover alternativas que maximizem os resultados produtivos do setor. Nesse contexto, o objetivo deste experimento foi analisar os resultados e variações da cultura do milho, em relação ao seu desenvolvimento e produtividade, obtida em diferentes profundidades de plantio. O experimento foi implantado em condições de campo, utilizando o delineamento em blocos casualizados, constituídos de 4 tratamentos e 4 repetições, em 4 linhas, espaçadas a 0,55 metros entre linhas e 16 metros de comprimento, totalizando 35,2m² por parcela. Foram empregados quatro tratamentos: 1, 2, 3 e 4, definidos a 1 cm, 3 cm, 5 cm e 7 cm respectivamente. Foram avaliados os seguintes parâmetros: índice de velocidade de emergência, diâmetro de colmo, altura da planta e produtividade. Com este estudo, observou-se que o índice de velocidade de emergência sofre influência da profundidade de semeadura, quanto menor, mais rápido a planta emerge. Em relação à produtividade, o resultado foi inverso ao IVE, ou seja, quanto maior a profundidade, melhor o índice produtivo da cultura analisada, ratificado pelo melhor índice de diâmetro do colmo, altura e produção.
Las irregularidades en el procedimiento disciplinario de la UAE Junta Central de Contadores
Authors: Díaz Acosta Helga Lidby , López Sánchez Juan Fernando
Published: December 2019

En este trabajo de investigación se estudiará y verificará el procedimiento disciplinario del Tribunal de Ética de la Unidad Administrativa Especial Junta Central de Contadores, ente encargado de vigilar el ejercicio de la profesión contable. Para esto, se contextualiza al lector en el origen de este Tribunal, su evolución histórica a partir de las diferentes reformas normativas y la comparación con tribunales o entes afines de otros países, con el objetivo de identificar las irregularidades en el procedimiento disciplinario; toda vez que se han advertido anomalías relacionadas con la aplicación de figuras jurídicas como la caducidad y la prescripción; la inexistencia de una segunda instancia, así como inconsistencias en las etapas del procedimiento aplicado actualmente en Colombia para la vigilancia de la profesión contable.Para el efecto, se hará una recopilación de documentación, se analizará el procedimiento establecido, en comparación con otras leyes que regulan este tipo de procedimientos disciplinarios, en aras de determinar si es necesario un replanteamiento, a fin de que los procesos adelantados por el Tribunal Disciplinario garanticen los derechos de los investigados, y opere en armonía con los principios que rigen la profesión contable y los principios propios del Derecho disciplinario
Mass customization en el sector textil colombiano - caso fabricato
Authors: Marulanda Valencia Flor Ángela , Higuita López Daimer , Márquez José
Published: December 2019

This document addresses the organizational strategy undertaken by the Fabricato company since 2014. Specifically, the text analyzes the materialization of the strategy through the so-called Mass Customization. To do so, in addition to the literature review, the case study research had primary sources such as interviews, conferences, reports from the company’s presidency, and secondary sources such as books, press articles and magazines. Consequently, the paper presents practices and decisions necessary for the realization of the strategy, such as the acquisition of the new technology and the role of the people or collaborators. This strategy, used by world-class companies, will involve Fabricato into a greater relationship with end customers, an update in its production lines and an education campaign for future consumers. This will allow an advantage over the large volume market suppliers, by providing greater added value and therefore the possibility of having better prices.
Aproximaciones sobre la incidencia de los reportes de sostenibilidad y gobierno corporativo en el valor de las empresas: evidencia desde Chile y Colombia
Authors: Correa Mejía Diego Andrés , Hernández Serna Dennys Paulina , Gutiérrez Castañeda Belky Esperanza , Lopera Castaño Mauricio
Published: December 2019

Sustainability reports allow companies to show their social and environmental commitment, these revelations transcend the financial sphere but impact on it. The objective of this study is to analyze the impact of the corporate governance structure and sustainability reports on the firm value, thus nourishing the discussion around the issue, especially in emerging areas such as Latin America, where the related theoretical developments are incipient. The technique used was the unbalanced data panel, with a total of 280 company-year observations. Based on the theoretical review and the hypothesis put forward in Colombian and Chilean companies, elements were found to conclude that there is a positive relationship between the presentation of sustainability reports and the generation of firm value.
Una propuesta metodológica para la gestión integral de los puertos marítimos
Authors: Valenzuela Jiménez Luis Fernando , Giner Fillol Arturo , Ripoll Feliu Vicente
Published: December 2019

Globalization has its support in the international exchange of goods, where maritime ports play a key role, so the competitiveness of countries is determined by the ability of these nodes of the global network to meet the demands of the various actors who demand their services.
World classifications are periodically published on the performance of maritime ports, taking into account quantitative factors, while giving less importance to other criteria that the actors of the port logistics chain value for their qualification. In this regard, this research paper presents a comprehensive evaluation model with eight criteria, following the multicriteria methodology with the Thomas Saaty technique, with a weighting of dominance among the criteria assigned by sector experts through an online survey.
It is provided a practical example with five ports to demonstrate that the best ports adequately combine the various criteria to achieve the goal o providing quality services, ensuring that ships and containers stay as little timeas possible in their facilities.
Cost variation analysis of hypolipidemic drugs currently available in Indian pharmaceutical market
Authors: Sondarva Divyesh B. , Hirpara Hiren N.
Published: December 2019

Background: Indian pharmaceutical industry is one of the growing pharmaceutical markets in the world having number of formulations available with large difference in prices. Price variations of such drugs which are used by large number of population have major economical implication. Hyperlipidemia is major risk factor for ischaemic heart diseases. So we planned this study to find out variation in cost of oral hypolipidemic drugs available in India either as a single drug or as fixed dose combination (FDCs) and to compare cost of their generic version with brands.Methods: The prices of single and FDCs of hypolipidemic drugs were taken from “Indian Drug Review 2018” and “Current Index of Medical Specialities during October 2018 to December 2018”. Maximum and minimum prices of various hypolipidemic drugs of same strength and dosage forms manufactured by different companies were taken.Results: Minimum cost variations are 3.62% (pravastatin 10 mg) and 3.37% (rosuvastatin 5 mg and fenofibrate 67 mg). Maximum cost variations are 500% (simvastatin 5 mg) and 500.32% (atorvastatin 10 mg and fenofibrate 160 mg). Wide variations are found in cost of brand drug with generic version of same strength components. None of the pharmaceutical companies are selling drugs cheaper than or equal to the cost of generic drugs of same strength.Conclusions: Most of hypolipidemic drugs should come under control of Drug Price Control Order so that financial burden of healthcare services on Indian population can be reduced and by adherence to treatment will improve health status of the community.
Assessment of efficacy of promethazine on seizure activity and its interactions with antiepileptic drugs lorazepam and sodium valproate in rats
Authors: Shinde Vinod , Warudkar Sandesh
Published: December 2019

Background: Presently available antiepileptic drugs are effective in controlling seizures in more than half of patients of all epilepsy but use is often limited by adverse effects. H1 receptor antagonists, have a controversial status in patients of epilepsy. Both pro and antiepileptic effect has been documented in various animal studies. Hence, this study was designed to see the effect of promethazine, an H1 antihistaminic drug and its interactions with antiepileptic drugs lorazepam and sodium valproate in rats.Methods: The effect of promethazine (10 mg/kg) and its interactions with antiepileptic drugs lorazepam and sodium valproate was assessed by using maximal electroshock seizures (MES) and chemoshock pentylenetetrazol (PTZ) method.Results: Promethazine along with lorazepam and sodium valproate in subtherapeutic doses exerted significant protection against MES induced seizures whereas no such protection was observed with PTZ method rather the seizure threshold was reduced.Conclusions: Subtherapeutic doses of promethazine alone and in combination with lorazepam and sodium valproate showed protection against seizures in MES method. However, proconvulsant effect was seen with PTZ method. This shows dual behavior of promethazine on MES and PTZ induced seizures.
Clinical pattern and presentation of abnormal uterine bleeding
Authors: V. Sarala , Gopalan Ushadevi
Published: December 2019

Background: Abnormal uterine bleeding (AUB) is a very common debilitating gynecological condition among women of the reproductive age group. This diagnosis is given to women in whom no clear etiology is identified. It can occur in ovulatory and anovulatory cycle. It influences the physical, emotional, sexual and professional life of a woman. This study was carried out to evaluate the clinical profile of abnormal uterine bleeding.Methods: This cross-sectional study was carried out among 350 patients who were clinically diagnosed with AUB for a period of one year from April 2018 to March 2019. Patients with uterine polyp, adenomyosis, Leiomyoma, malignancies and with various coagulopathies were excluded from the study by physical examination, ultrasound, histopathology and blood test. The remaining 280 patients between the ages 20-60 years were selected for clinical classification of AUB.Results: Majority of the participants were in the age group of 41-50 years (60%). AUB is most commonly seen in multiparous women (48.92%). The prominent bleeding pattern seen was menorrhagia (52.2%).Conclusions: Menorrhagia is the most common form of AUB and there is a need to prevent the consequences of menorrhagia by way of creating awareness among the women, and by early diagnosis and clinical management of complications.
Sirenomelia with Potter syndrome: a case report and review of literature
Authors: Singh Amrita , Kumari Anupma
Published: December 2019

Sirenomelia or mermaid syndrome is a rare congenital anomaly characterized by variable degree of fusion of lower extremities. Awareness to this rare condition is important for prenatal diagnosis and prognosticating the fetus. The exact etiopathogenesis is still an area of research. Two pathogenic hypotheses are the vascular steal hypothesis and the defective blastogenesis hypothesis with exceptions reported in literature.
A comparative prospective randomised controlled study for mesh fixation by cyanoacrylate glue versus prolene sutures in patients undergoing Lichtenstein hernioplasty
Authors: Kalwaniya Dheer S. , Arya Satya V. , Gupta Sumedha , Kuppuswamy Manigandan , Bajwa Jaspreet S. , Paruthi Shivani B. , Mahadevan Ranjith , Choudhary Rohit , R. Monish , Singla Nipun
Published: December 2019

Background: Inguinal hernia repair is one of the most commonly performed procedures by general surgeons. Cyanoacrylate is the generic name for a family of fast acting adhesives. The aim of the present study done in Department of General Surgery, Safdarjung Hospital, New Delhi was to compare the newer emerging technique of mesh fixation.Methods: A total of sixty patients were included in the present study and were allotted in case and control group randomly by sealed envelope technique. In case (study) group, all the patients underwent mesh fixation by cyanoacrylate glue and in control group, by prolene 3-0 sutures.Results: Most frequency in age group 31-40 yrs, males:females ratio >1 and right sided inguinal hernia was more common. Bi-lateral hernia was common in elderly. Indirect: direct ratio 4.5:1. Operating time period for the patients of the case (study) group is less than control group. P value of post-operative pain in immediate post-operative period (day 1 and 2) and POD 30, 60 and 90 was not of clinical significance whereas the p-value on 6,120,150 and 180 post op day was of clinical significance. In our study, there was a case of incidental observation: a) reaction due to use of cyanoacrylate glue, b) rejection of mesh for which mesh had to be removed.Conclusions: There is no statistically significant difference between mesh fixation with cyanoacrylate glue and mesh fixation by prolene suture techniques in immediate post-operative pain. Statistically significant difference favoring mesh fixation by cyanoacrylate glue technique was seen with respect to operating time and post-operative groin pain with increasing post-operative duration.
Efikasi Diri dan Keterlibatan Orangtua dalam Pendidikan dengan Self Regulated Learning
Authors: Nugroho Andreas Yudha Fery
Published: December 2019

This study aimed at determining the improvement of the quality of students who refered to several factors, namely self-regulated learning, self-efficacy and parental involvement in Education using a quantitative research approach with the Self-Efficiency scale, the scale of parental involvement in education and the scale of self-regulated learning. In this study it could be said that the ability of self-efficacy and parent involvement in education were able to predict the ability of self-regulated learning. Junior high school students realized that their abilities were supported by parents who provided assistance in the learning process would make it easier to regulate teenage learning activities.Abstrak. Penelitian ini bertujuan untuk mengetahui peningkatan kualitas pebelajar yang merujuk pada beberapa faktor yaitu self-regulated learning, efikasi diri dan keterlibatan orangtua dalam Pendidikan dengan menggunakan pendekatan penelitian kuantitatif dengan skala Efikasi Diri, Skala keterlibatan orangtua dalam pendidikan dan Skala self regulated learning. Pada penelitian ini dapat dikatakan bahwa kemampuan efikasi diri dan Keterlibatan orangtua dalam pendidikan mampu memprediksi kemampuan self regulated learning. Remaja SMP menyadari akan kemampuan yang mereka miliki didukung oleh orangtua yang memberikan bantuan dalam proses belajar akan mempermudah dalam meregulasi kegiatan belajar remaja.
Budaya Organisasi dan Gaya Kepemimpinan Transformasional dalam Komitmen Resimen Mahasiswa
Authors: Ardaniyati Lisa , Mujib Abdul , Luzvinda Liany
Published: December 2019

This study aimed at determining the effect of organizational culture and transformational leadership styles on organizational commitment to student regiments. This study used a quantitative approach to the method of multiple regression and sampling using non-probability sampling with purposive sampling technique. The results of this study indicated that based on hypothesis testing using multiple regression, R square values (R2) of all research variables tested were 0.410 or 41.0% with a significant value of 0,000 or p 0.05 while F calculated was 7,422 from F table 4.4. This showed that there was a significant influence of organizational culture and transfomational leadership style so that the higher the awareness of members of the organizational culture and transformational leadership style that was applied, would increase commitment to the organization. AbstrakPenelitian ini bertujuan untuk mengetahui pengaruh budaya organisasi dan gaya kepemimpinan transformasional terhadap komitmen organisasi pada resimen mahasiswa. Penelitian ini menggunakan pendekatan kuantitatif metode multipel regression dan pengambilan sampel mengunakan non-probability sampling dengan teknik sampling purposive. Hasil penelitian ini menunjukan bahwa berdasarkan uji hipotesis menggunakan multipel regression, didapatkan nilai R square (R2) dari semua variabel penelitian yang diujikan yaitu 0,410 atau 41,0% dengan nilai signifikan sebesar 0,000 atau p0,05 sementara F hitung didapat sebesar 7.422dari F tabel 4.4. Hal ini menunjukan bahwa terdapat pengaruh signifikan budaya organisasi dan gaya kepemimpinan transfomasional sehingga semakin tinggi kesadaran anggota terhadap budaya organisasi dan gaya kepemimpinan transformasional yang diterapkan maka akan meningkatkan komitmen terhadap organisasi.
Modulation of GAPDH expression and cellular localization after vaccinia virus infection of human adherent monocytes.
Authors: Nahlik Krystyna W , Mleczko Anna K , Gawlik Magdalena K , Rokita Hanna B
Published: December 2019

Vaccinia virus is able to replicate in many cell types and is known to modulate apoptosis in infected cells. In this study, expression of apoptosis-related genes was screened in human adherent monocytes after vaccinia infection using a DNA array. A marked increase of the key glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression was found. Increased expression and nuclear translocation of GAPDH have recently been reported to participate in apoptosis of many cell types. To confirm the array results, levels of GAPDH mRNA were estimated by RT-PCR, showing an increase at 4 h p.i. followed by a slight decrease, which correlated with the viral anti-apoptotic E3L gene transcript levels. Subcellular localization of the enzyme in human monocytes was examined by Western blot and immunostaining of the infected cells. Both experiments revealed accumulation of GAPDH in the nucleus at 14 h p.i., which was completely suppressed at 24 h p.i. This might indicate GAPDH as a novel target for vaccinia anti-apoptotic modulation.
Molecular dynamics simulations of charged and neutral lipid bilayers: treatment of electrostatic interactions.
Authors: Róg Tomasz , Murzyn Krzysztof , Pasenkiewicz-Gierula Marta
Published: December 2019

Molecular dynamics (MD) simulations complement experimental methods in studies of the structure and dynamics of lipid bilayers. The choice of algorithms employed in this computational method represents a trade-off between the accuracy and real calculation time. The largest portion of the simulation time is devoted to calculation of long-range electrostatic interactions. To speed-up evaluation of these interactions, various approximations have been used. The most common ones are the truncation of long-range interactions with the use of cut-offs, and the particle-mesh Ewald (PME) method. In this study, several multi-nanosecond cut-off and PME simulations were performed to establish the influence of the simulation protocol on the bilayer properties. Two bilayers were used. One consisted of neutral phosphatidylcholine molecules. The other was a mixed lipid bilayer consisting of neutral phosphatidylethanolamine and negatively charged phosphatidylglycerol molecules. The study shows that the cut-off simulation of a bilayer containing charge molecules generates artefacts; in particular the mobility and order of the charged molecules are vastly different from those determined experimentally. In the PME simulation, the bilayer properties are in general agreement with experimental data. The cut-off simulation of bilayers containing only uncharged molecules does not generate artefacts, nevertheless, the PME simulation gives generally better agreement with experimental data.
The bovine tyrosine hydroxylase gene associates in vitro with the nuclear matrix by its first intron sequence.
Authors: Lenartowski Robert , Grzybowski Tomasz , Miścicka-Sliwka Danuta , Wojciechowski Waldemar , Goc Anna
Published: December 2019

Recently we have shown that in vitro binding of the proximal part of the human tyrosine hydroxylase gene to the nuclear matrix is correlated with its transcriptional activity. The strongest binding potential was predicted by computing for the first intron sequence (Lenartowski & Goc, 2002, Neurosci Lett.; 330: 151-154). In this study a 16 kb fragment of the bovine genomic DNA containing the tyrosine hydroxylase gene was investigated for its affinity to the nuclear matrix. Only a 950 bp fragment encoding the distal part of the first intron, second exon and a few nucleotides of the second intron bound to the nuclear matrix. The binding was independent of the tissue-specific tyrosine hydroxylase gene activation. The fragment was subcloned and sequenced. Computer search pointed to one potential intronic matrix attachment region with two AP1-like sites embedded in the sequence. We conclude that even if the position of the matrix binding region is conserved among the tyrosine hydroxylase genes in mammals, its tissue specificity and/or function is not preserved or is achieved by different mechanisms.
Effect of glycosaminoglycans accumulation on the non-oxidative sulfur metabolism in mouse model of Sanfilippo syndrome, type B
Authors: Kaczor-Kamińska Marta , Kamiński Kamil , Stalińska Krystyna , Wróbel Maria , Feldman Arleta
Published: December 2019

Lack of the N-alpha-acetylglucosaminidase gene is responsible for the occurrence of a rare disease – the Sanfilippo syndrome, type B. The result of this gene knock-out is accumulation of glycosaminoglycans (GAGs) – more specifically heparan sulfate – a sulfate rich macromolecule. The sulfur oxidative pathway is involved in the sulfate groups’ turnover in the cells. In contrast, the non-oxidative sulfur pathway leads mostly to formation of sulfane sulfur-containing compounds. The aim of our research was to observe an interaction between MPS IIIB and non-oxidative sulfur metabolism. In this work, we examined selected tissues (livers, kidneys, hearts and spleens) of 3 month old mice with confirmed accumulation of GAGs. The activity and expression of three sulfurtransferases (components of non-oxidative sulfur metabolism): rhodanese, 3-mercaptopyruvate sulfurtransferase and cystathionine γ-lyase was determined, as well as the sulfane sulfur level and the level of other low molecular sulfur-containing compounds (reduced and oxidized glutathione, cysteine and cystine). In all tested tissues, the sulfane sulfur and/or sulfurtransferases’ activities, as well as the cysteine content, underwent statistically significant changes. These correlations were also related to the sex of the tested animals. The obtained results indicated that accumulation of incompletely degraded GAGs in the tissues had affected the non-oxidative sulfur metabolism.
CARACTERIZAÇÃO DE PESSOAS JOVENS COM INFARTO AGUDO DO MIOCÁRDIO
Authors: Moraes Lima Maria Lucila Nobre , Magalhaes Jamile Silva , Dos Santos Taciana Ferreira , Peixoto Paula Silva , Rodrigues Gilmara Ribeiro Santos
Published: December 2019

Objetivo: caracterizar a apresentação clínica de adultos jovens diagnosticados com infarto agudo do miocárdio. Método: pesquisa documental com abordagem quantitativa. Utilizou-se um formulário sobre aspectos sociodemográficos e clínicos. A amostra foi composta por 12 prontuários, de pacientes com idade entre 25 e 45 anos. Os dados coletados foram tabulados em uma planilha do Excel e, após análise, foram apresentados em frequências absolutas. Resultados: predominou o sexo masculino, com Supra de ST, faixa etária entre 35 e 45 anos de idade, com sobrepeso e sem antecedentes familiares. Dor torácica foi encontrada em 91,66% dos jovens, 58,33% não faziam uso de medicação contínua e 100% tiveram elevação da troponina e realizaram cateterismo cardíaco. Conclusão: o quadro de apresentação clínica na população jovem estudada ficou dentro dos parâmetros gerais para o diagnóstico do infarto agudo do miocárdio.

 

Descritores: Infarto do Miocárdio. Fatores de Risco. Doenças Cardiovasculares. Diagnóstico. Epidemiologia.

 
A IMPORTÂNCIA DA EDUCAÇÃO FÍSICA NA VISÃO DOS ALUNOS DE UMA ESCOLA PÚBLICA
Authors: GOZI Paulo Ricardo Brasilio , MORAES João Carlos Pereira de
Published: December 2019

Este trabalho tem por objetivo analisar a percepção dos alunos em relação ao interesse pelas aulas de Educação Física de uma escola pública no interior do estado do Paraná. Para tanto, foi realizado um questionário com 15 questões e aplicado a 39 estudantes de ambos os sexos de uma escola pública localizada na cidade em questão. Como resultado, percebem-se aulas com atividades repetitivas, alunos poucos motivados para participação nas aulas práticas e, mesmo assim, uma escola bem preparada em sua infraestrutura para as atividades. Por fim, evidencia-se a ausência de um projeto comum para a atuação docente em Educação Física que motivasse e possibilitasse aos sujeitos se aproximar e participar ativamente das aulas da disciplina.
ANÁLISE DO CURSO DE ENGENHARIA INDUSTRIAL DA UFPA ABAETETUBA EMPREGANDO O MÉTODO SERVQUAL NA PERCEPÇÃO DISCENTE
Authors: MARTINS Harley Dos santos , LOBATO Beatriz Cardoso , SANTOS Ismael Gomes dos , MELO Andreza Negrão , RODRIGUES Stefane Dias
Published: December 2019

O objetivo deste trabalho é desenvolver uma pesquisa quantitativa, fazendo levantamento das expectativas e percepções dos alunos de engenharia industrial em relação ao curso. Os dados da pesquisa foram coletados a partir de aplicação de questionários online, utilizando a ferramenta googleforms, e questionários impressos. As informações coletadas foram tabuladas calculando-se assim os gaps para analisar pontos negativos e positivos, onde se destaca que as maiores lacunas encontradas foram os itens que tratam da cantina (-1,264), divulgação de informações de eventos e serviços de interesse aos discentes (-1,321) e laboratórios específicos do curso (-1,377). Por fim, utilizando a ferramenta da qualidade 5W1H, se propôs um plano de ação para aperfeiçoar processos e evitar erros e insatisfações.
What are the critical dimensions in Ghana's senior high school social studies curriculum? Under the lens of a critical global citizenship education framework
Authors: Angyagre Simon Eten , Quainoo Albert Kojo
Published: December 2019

A review of school curricula approaches to citizenship formation in a sub-Saharan African education context reveals such practice is still largely focused on a traditional social studies approach. This approach to citizenship development may be limiting in terms of potential to foster
students' civic competencies for addressing social injustice associated with the impacts of globalization that impinge on local realities. Drawing on a critical global citizenship education (GCE) framework and GCE core conceptual dimensions developed by UNESCO, this study assessed the critical
dimensions of the social studies curriculum for secondary education in one sub-Saharan African country. Through interviews with teachers, focus groups with students and a review of the social studies teaching syllabus, the study revealed limitations in both content and the pedagogical approach
to the delivery of Ghana's current social studies curriculum for senior high schools.
Seeking equilibrium between a social justice and a charity stance towards global learning among Northern Ireland pupils
Authors: Clarke Linda , Abbott Lesley
Published: December 2019

Developing pupils' knowledge and understanding of world poverty and how to reduce it requires building teachers' capacity. With this objective in mind, the UK Global Learning Programme (GLP 2013–18) sought to determine the extent to which a social justice mentality was evident
among pupils in Northern Ireland schools in tandem with, or instead of, the prevailing charity mentality. Using a qualitative approach, the research examined their conceptions of, and attitudes towards, social justice and equity, and how they had helped make the world fairer. They understood
the causes of inequality and saw the contrast between great wealth and absolute poverty. Their growing motivation to help related mainly to charitable actions, but there was evidence of critical thinking about longer-term implications and a social justice stance.