bluuebunny/crossref_metadata_2025 huggingface dataset:
Seventh Circuit Allows Informed Consent Claim Under FTCA
Authors: W.M.S.
Published: January 2021

The United States Court of Appeals for the Seventh Circuit held, in Murrey v. United States (73 F.3d 1448 (7th Cir. 1996)), that claims for a physician's failure to obtain a patient's informed consent are not barred by the Federal Tort Claims Act (FTCA) as a species of misrepresentation. The court further held that the claim was not barred by the failure to include the issue of informed consent in the administrative claim. This decision reduces the burden on plaintiffs to state every cognizable claim consistent with the facts in an administrative proceeding; the failure to do so would prevent them from raising the claim in court.

The patient, Thomas Murrey, a sixty-eight-year-old U.S. veteran, sought treatment at a Veteran's Administration (VA) hospital in North Chicago, Illinois. VA doctors diagnosed him with prostate cancer, and advised him to undergo surgery to remove his entire prostate.
Challenges in the Federal Regulation of Pain Management Technologies
Authors: Noah Lars
Published: January 2021

Both the Food and Drug Administration (FDA) and the Drug Enforcement Administration (DEA) play a role in regulating pain management technologies, including pharmaceutical products and medical devices indicated for analgesic use. Yet, as things stand, these two key federal entities, with their distinctly different missions and cultures, contribute to the persistent undertreatment of pain through both overregulation and duplicative regulation. The solution lies in refining pain regulation so that a better balance is created between the need to ensure patient access to pain relief and the need to prevent and reduce drug diversion.

Various federal regulatory mechanisms — such as limits on supplies and distribution channels — have created barriers that ultimately affect access to pain management technologies for legitimate users. As the FDA and DEA focus their attention on the misuse of legitimate pain technologies, patients ultimately may be deprived of valuable analgesic agents.
Monitoring and Investigating Certified Registered Nurse Practitioners in Pain Management
Authors: Lazarus Jean B. , Downing Belinda (Wendy)
Published: January 2021

Nurses are on the front lines of pain management, yet in Alabama and eleven other states they are not legally authorized to prescribe any controlled pain medications. In this survey of certified registered nurse practitioners in Alabama, 83 percent of the nurses responding to a question about the connection between prescriptive authority and pain management said that the lack of prescriptive authority for controlled substances delays pain management treatment, and 88 percent of those proffering an opinion about the importance of prescriptive authority said that expanding their prescriptive authority to include those medications would improve patient outcomes.

At the same time, however, many nurses indicated that they are not adequately prepared to prescribe and manage pain medications. Fifty-five percent of the nurses responding to a question about whether they were prepared to make decisions when working under protocols related to controlled substances answered no. And 44 percent of the respondents to a question about the nurse practitioner educational curricula said that they did not feel their education had adequately prepared them for prescribing controlled pain medications.
Ohio Court Finds Blue Cross Liable for Misleading Copayment Charges
Authors: B.L.G.
Published: January 2021

On August 29, 1995, the United States District Court for the Northern District of Ohio ruled that certain practices of Blue Cross and Blue Shield of Ohio (BCBSO) relating to the calculation of copayments on insurance claims violated provisions of ERISA, and thus BCBSO could be liable for unpaid benefits and breach of fiduciary duty (McConocha v. Blue Cross & Blue Shield of Ohio, 1995 WL 561444 (N.D. Ohio Aug. 29, 1995)). According to BCBSO's Explanation of Benefits and Schedule of Benefits, beneficiaries were responsible for a 20 percent copayment for hospital charges, and the remaining 80 percent of the Provider's Reasonable Charges would be paid by BCBSO. BCBSO negotiated with the hospitals to create discount agreements whereby the actual charge to BCBSO was less than 80 percent of the total amount of the hospital's charges. By this arrangement, BCBSO paid less than 80 percent of what patients were billed; concurrently, patients paid more than 20 percent of the amount ultimately paid to hospitals for their services.
A novel UBE2T inhibitor suppresses Wnt/β-catenin signaling hyperactivation and gastric cancer progression by blocking RACK1 ubiquitination
Authors: Yu Zeyuan , Jiang Xiangyan , Qin Long , Deng Haixiao , Wang Jianli , Ren Wen , Li Hongbin , Zhao Lei , Liu Huanxiang , Yan Hong , Shi Wengui , Wang Qi , Luo Changjiang , Long Bo , Zhou Huinian , Sun Hui , Jiao Zuoyi
Published: January 2021

Dysregulation of the Wnt/β-catenin signaling pathway is critically involved in gastric cancer (GC) progression. However, current Wnt pathway inhibitors being studied in preclinical or clinical settings for other cancers such as colorectal and pancreatic cancers are either too cytotoxic or insufficiently efficacious for GC. Thus, we screened new potent targets from β-catenin destruction complex associated with GC progression from clinical samples, and found that scaffolding protein RACK1 deficiency plays a significant role in GC progression, but not APC, AXIN, and GSK3β. Then, we identified its upstream regulator UBE2T which promotes GC progression via hyperactivating the Wnt/β-catenin signaling pathway through the ubiquitination and degradation of RACK1 at the lysine K172, K225, and K257 residues independent of an E3 ligase. Indeed, UBE2T protein level is negatively associated with prognosis in GC patients, suggesting that UBE2T is a promising target for GC therapy. Furthermore, we identified a novel UBE2T inhibitor, M435-1279, and suggested that M435-1279 acts inhibit the Wnt/β-catenin signaling pathway hyperactivation through blocking UBE2T-mediated degradation of RACK1, resulting in suppression of GC progression with lower cytotoxicity in the meantime. Overall, we found that increased UBE2T levels promote GC progression via the ubiquitination of RACK1 and identified a novel potent inhibitor providing a balance between growth inhibition and cytotoxicity as well, which offer a new opportunity for the specific GC patients with aberrant Wnt/β-catenin signaling.
C-terminal truncated HBx initiates hepatocarcinogenesis by downregulating TXNIP and reprogramming glucose metabolism
Authors: Zhang Yu , Yan Qian , Gong Lanqi , Xu Hang , Liu Beilei , Fang Xiaona , Yu Dandan , Li Lei , Wei Ting , Wang Ying , Wong Ching Ngar , Lyu Zhaojie , Tang Ying , Sham Pak Chung , Guan Xin-Yuan
Published: January 2021

Chronic hepatitis B virus (HBV) infection is strongly associated with the initiation and development of hepatocellular carcinoma (HCC). However, the genetic alterations and pathogenesis mechanisms remain significantly unexplored, especially for HBV-induced metabolic reprogramming. Analysis of integration breakpoints in HBV-positive HCC samples revealed the preferential clustering pattern within the 3′-end of X gene in the HBV genome, leading to the production of C-terminal truncated X protein (Ct-HBx). In this study, we not only characterized the oncogenic role of two Ct-HBx (HBx-120 and HBx-134) via in vitro and in vivo functional assays but also deciphered their underlying molecular mechanisms. Gene expression profiling by transcriptome sequencing identified potential targets of Ct-HBx and novel malignant hallmarks such as glycolysis, cell cycle, and m-TORC1 signaling in Ct-HBx-expressing cells. TXNIP, a well-established regulator of glucose metabolism, was shown to be downregulated by Ct-HBx and play a pivotal role in Ct-HBx-mediated HCC progression. Suppression of TXNIP is frequently observed in HCC patients with Ct-HBx expression and significantly (P = 0.015) correlated to a poorer prognosis. Re-introduction of TXNIP attenuated the metabolic reprogramming induced by the Ct-HBx and inhibited the tumor growth in the mice model. Further study suggested that Ct-HBx could downregulate TXNIP via a transcriptional repressor nuclear factor of activated T cells 2 (NFACT2). Collectively, our findings indicate that TXNIP plays a critical role in Ct-HBx-mediated hepatocarcinogenesis, serving as a novel therapeutic strategy in HCC treatment.
Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy
Authors: Lechner Matt , Schartinger Volker H. , Steele Christopher D. , Nei Wen Long , Ooft Marc Lucas , Schreiber Liesa-Marie , Pipinikas Christodoulos P. , Chung Grace Tin-Yun , Chan Yuk Yu , Wu Feng , To Ka-Fai , Tsang Chi Man , Pearce Wayne , Morelli Daniele , Philpott Martin , Masterson Liam , Nibhani Reshma , Wells Graham , Bell Christopher G. , Koller Julia , Delecluse Susanne , Yip Yim Ling , Liu Jacklyn , Forde Cillian T. , Forster Martin D. , Jay Amrita , Dudás József , Krapp Annika , Wan Simon , Uprimny Christian , Sprung Susanne , Haybaeck Johannes , Fenton Tim R. , Chester Kerry , Thirlwell Christina , Royle Gary , Marafioti Teresa , Gupta Rajeev , Indrasari Sagung Rai , Herdini Camelia , Slim Mohd Afiq Mohd , Indrawati I. , Sutton Liam , Fles Renske , Tan Bing , Yeong Joe , Jain Amit , Han Shuting , Wang Haitao , Loke Kelvin S. H. , He Wan , Xu Ruilian , Jin Hongtao , Cheng Zhiqiang , Howard David , Hwang Peter H. , Le Quynh-Thu , Tay Joshua K. , West Robert B. , Tsao Sai Wah , Meyer Tim , Riechelmann Herbert , Oppermann Udo , Delecluse Henri-Jacques , Willems Stefan M. , Chua Melvin L. K. , Busson Pierre , Lo Kwok Wai , Wollmann Guido , Pillay Nischalan , Vanhaesebroeck Bart , Lund Valerie J.
Published: January 2021

Nasopharyngeal cancer (NPC), endemic in Southeast Asia, lacks effective diagnostic and therapeutic strategies. Even in high-income countries the 5-year survival rate for stage IV NPC is less than 40%. Here we report high somatostatin receptor 2 (SSTR2) expression in multiple clinical cohorts comprising 402 primary, locally recurrent and metastatic NPCs. We show that SSTR2 expression is induced by the Epstein–Barr virus (EBV) latent membrane protein 1 (LMP1) via the NF-κB pathway. Using cell-based and preclinical rodent models, we demonstrate the therapeutic potential of SSTR2 targeting using a cytotoxic drug conjugate, PEN-221, which is found to be superior to FDA-approved SSTR2-binding cytostatic agents. Furthermore, we reveal significant correlation of SSTR expression with increased rates of survival and report in vivo uptake of the SSTR2-binding 68Ga-DOTA-peptide radioconjugate in PET-CT scanning in a clinical trial of NPC patients (NCT03670342). These findings reveal a key role in EBV-associated NPC for SSTR2 in infection, imaging, targeted therapy and survival.
Benchmarking joint multi-omics dimensionality reduction approaches for the study of cancer
Authors: Cantini Laura , Zakeri Pooya , Hernandez Celine , Naldi Aurelien , Thieffry Denis , Remy Elisabeth , Baudot Anaïs
Published: January 2021

High-dimensional multi-omics data are now standard in biology. They can greatly enhance our understanding of biological systems when effectively integrated. To achieve proper integration, joint Dimensionality Reduction (jDR) methods are among the most efficient approaches. However, several jDR methods are available, urging the need for a comprehensive benchmark with practical guidelines. We perform a systematic evaluation of nine representative jDR methods using three complementary benchmarks. First, we evaluate their performances in retrieving ground-truth sample clustering from simulated multi-omics datasets. Second, we use TCGA cancer data to assess their strengths in predicting survival, clinical annotations and known pathways/biological processes. Finally, we assess their classification of multi-omics single-cell data. From these in-depth comparisons, we observe that intNMF performs best in clustering, while MCIA offers an effective behavior across many contexts. The code developed for this benchmark study is implemented in a Jupyter notebook—multi-omics mix (momix)—to foster reproducibility, and support users and future developers.
Regular exercise counteracts circadian shifts in core body temperature during long-duration bed rest
Authors: Mendt Stefan , Gunga Hanns-Christian , Felsenberg Dieter , Belavy Daniel L. , Steinach Mathias , Stahn Alexander C.
Published: January 2021

With NASA’s plans for the human exploration of Mars, astronauts will be exposed to mission durations much longer than current spaceflight missions on the International Space Station. These mission durations will increase the risk for circadian misalignment. Exercise has gained increasing interest as a non-pharmacological aid to entrain the circadian system. To assess the potential of exercise as a countermeasure to mitigate the risk for circadian disorders during spaceflight, we investigated the effects of long-term head-down tilt bed rest (HDBR) with and without exercise on the circadian rhythm of core body temperature. Core body temperature was recorded for 24 h using a rectal probe in sixteen healthy men (age: 30.5 ± 7.5 years (mean ± SD)) after 7 days and 49 days of HDBR. Five participants underwent HDBR only (CTR), five participants underwent HDBR and performed resistive exercises (RE), and six participants underwent HDBR and performed resistive exercises superimposed with vibrations (RVE). The exercise was scheduled three times per week. CTR showed a phase delay of 0.69 h. In contrast, both exercise groups were characterized by a phase advance (0.45 h for RE and 0.45 h for RVE; p = 0.026 for interaction between time and group). These findings suggest that resistive exercise (with or without vibration) may also serve as a countermeasure during spaceflight to mitigate circadian misalignments. The results could also be important for increasing awareness about the role of circadian disorders in long-term bedridden patients.
The band-edge excitons observed in few-layer NiPS3
Authors: Ho Ching-Hwa , Hsu Tien-Yao , Muhimmah Luthviyah Choirotul
Published: January 2021

Band-edge excitons of few-layer nickel phosphorous trisulfide (NiPS3) are characterized via micro-thermal-modulated reflectance (μTR) measurements from 10 to 300 K. Prominent μTR features of the A exciton series and B are simultaneously detected near the band edge of NiPS3. The A exciton series contains two sharp A1 and A2 levels and one threshold-energy-related transition (direct gap, E∞), which are simultaneously detected at the lower energy side of NiPS3. In addition, one broadened B feature is present at the higher energy side of few-layer NiPS3. The A series excitons may correlate with majorly d-to-d transition in the Rydberg series with threshold energy of E∞ ≅ 1.511 eV at 10 K. The binding energy of A1 is about 36 meV, and the transition energy is A1 ≅ 1.366 eV at 300 K. The transition energy of B measured by μTR is about 1.894 eV at 10 K. The excitonic series A may directly transit from the top of valence band to the conduction band of NiPS3, while the B feature might originate from the spin-split-off valence band to the conduction band edge. The direct optical gap of NiPS3 is ~1.402 eV at 300 K, which is confirmed by μTR and transmittance experiments.
Controllability over stressor decreases responses in key threat-related brain areas
Authors: Limbachia Chirag , Morrow Kelly , Khibovska Anastasiia , Meyer Christian , Padmala Srikanth , Pessoa Luiz
Published: January 2021

Controllability over stressors has major impacts on brain and behavior. In humans, however, the effect of controllability on responses to stressors is poorly understood. Using functional magnetic resonance imaging (fMRI), we investigated how controllability altered responses to a shock-plus-sound stressor with a between-group yoked design, where participants in controllable and uncontrollable groups experienced matched stressor exposure. Employing Bayesian multilevel analysis at the level of regions of interest and voxels in the insula, and standard voxelwise analysis, we found that controllability decreased stressor-related responses across threat-related regions, notably in the bed nucleus of the stria terminalis and anterior insula. Posterior cingulate cortex, posterior insula, and possibly medial frontal gyrus showed increased responses during control over stressor. Our findings support the idea that the aversiveness of stressors is reduced when controllable, leading to decreased responses across key regions involved in anxiety-related processing, even at the level of the extended amygdala.
Site-specific modification and segmental isotope labelling of HMGN1 reveals long-range conformational perturbations caused by posttranslational modifications
Authors: Niederacher Gerhard , Urwin Debra , Dijkwel Yasmin , Tremethick David J. , Rosengren K. Johan , Becker Christian F. W. , Conibear Anne C.
Published: January 2021

Using protein semi-synthesis, segmentally isotope-labelled variants of nucleosome-binding protein HMGN1 were generated with site-specific posttranslational modifications to explore their structural and functional effects.
Syndiotactic PLA from meso-LA polymerization at the Al-chiral complex: a probe of DFT mechanistic insights
Authors: D'Alterio Massimo Christian , De Rosa Claudio , Talarico Giovanni
Published: January 2021

The mechanism(s) for the formation of syndiotactic PLA by the ROP of meso-LA by a chiral-Al-complex are disclosed by DFT calculations.
Artificial maturation of [FeFe] hydrogenase in a redox polymer film
Authors: Felbek Christina , Hardt Steffen , Papini Cecilia , Pramanik Debajyoti , Artero Vincent , Fontecave Marc , Fourmond Vincent , Plumeré Nicolas , Léger Christophe
Published: January 2021

We demonstrate that the insertion of the dinuclear active site of [FeFe] hydrogenase into the apo-enzyme can occur when the enzyme is embedded in a film of redox polymer, under conditions of mediated electron transfer.
Correction: Changes in macrocyclic aromaticity and formation of a charge-separated state by complexation of expanded porphyrin and C60
Authors: Cha Won-Young , Ahn Ahreum , Kim Taeyeon , Oh Juwon , Ali Rashid , Park Jung Su , Kim Dongho
Published: January 2021

Correction for ‘Changes in macrocyclic aromaticity and formation of a charge-separated state by complexation of expanded porphyrin and C60’ by Won-Young Cha et al., Chem. Commun., 2019, 55, 8301–8304, DOI: 10.1039/C9CC03928G.
Magnetic particles used in a new approach for designed protein crystallization
Authors: dos Santos Raquel , Romão Maria João , Roque Ana Cecília A. , Carvalho Ana Luísa
Published: January 2021

Designed protein crystallization using magnetic particles as additives in the crystallization of model case studies.
Tailoring the magnetic ordering of the Cr4O5/Fe(001) surface via a controlled adsorption of C60 organic molecules
Authors: Orlando Federico , Fratesi Guido , Onida Giovanni , Achilli Simona
Published: January 2021

We analyze the spinterface formed by C60 on Cr4O5/Fe(001) surface showing that the controlled adsorption of C60 molecules can induce FM or AFM magnetic patterning of the Cr atoms in the oxide layer.
Organic synthesis with the most abundant transition metal–iron: from rust to multitasking catalysts
Authors: Rana Sujoy , Biswas Jyoti Prasad , Paul Sabarni , Paik Aniruddha , Maiti Debabrata
Published: January 2021

The promising aspects of iron in synthetic chemistry are being explored for three-four decades as a green and eco-friendly alternative to late transition metals. This present review unveils these rich iron-chemistry towards different transformations.
Magnetically separable graphene-based Ni–Fe mixed metal oxide nanocubes derived from a Prussian- blue analogue: synthesis, structure and application in oxidative degradation of bisphenol A
Authors: Zhang Hao , Qin Jingyu , Gao Zhifeng , Meng Qi , He Guangyu , Chen Haiqun
Published: January 2021

Mixed metal oxide (MMO) nanocubes were prepared by calcining a Ni–Fe Prussian-blue analogue (Ni–Fe PBA) and then uniformly supported on reduced graphene oxide (RGO) through a simple hydrothermal reaction instead of the commonly used etching.
Controlling the selectivity of bimetallic platinum–ruthenium nanoparticles supported on N-doped graphene by adjusting their metal composition
Authors: Cerezo-Navarrete Christian , Mathieu Yannick , Puche Marta , Morales Cristina , Concepción Patricia , Martínez-Prieto Luis M. , Corma Avelino
Published: January 2021

Bimetallic platinum–ruthenium nanoparticles supported on N-doped graphene as chemoselective hydrogenation catalysts.
The three-spot seahorse-derived peptide PAGPRGPA attenuates ethanol-induced oxidative stress in LO2 cells through MAPKs, the Keap1/Nrf2 signalling pathway and amino acid metabolism
Authors: Shi Jie , Zhou Xin , Zhao Ying , Tang Xuemei , Feng Lu , Wang Boyuan , Chen Jian
Published: January 2021

An octapeptide PAGPRGPA defended against ethanol-induced oxidative stress in LO2 cells.
Gentisic acid prevents diet-induced obesity in mice by accelerating the thermogenesis of brown adipose tissue
Authors: Han Xue , Guo Jielong , Gao Yunxiao , Zhan Jicheng , You Yilin , Huang Weidong
Published: January 2021

Gentisic acid prevents diet-induced obesity in mice by accelerating the thermogenesis of brown adipose tissue.
Selective extraction of lithium from a spent lithium iron phosphate battery by mechanochemical solid-phase oxidation
Authors: Liu Kang , Liu Lili , Tan Quanyin , Li Jinhui
Published: January 2021

Lithium was selectively and environmentally friendly extracted from spent LiFePO4batteriesviamechanochemical solid-phase oxidation process.
Programmable multilayer printing of a mechanically-tunable 3D hydrogel co-culture system for high-throughput investigation of complex cellular behavior
Authors: Hong Jisu , Shin Yoonkyung , Lee Jiseok , Cha Chaenyung
Published: January 2021

Programmable multilayer printing is utilized to develop a 3D hydrogel co-culture system, consisting of a microgel array and hydrogel overlay with independently controlled mechanical properties and concurrent generation of mechanical gradients.
Flexible boron nitride-based memristor forin situdigital and analogue neuromorphic computing applications
Authors: Meng Jia-Lin , Wang Tian-Yu , He Zhen-Yu , Chen Lin , Zhu Hao , Ji Li , Sun Qing-Qing , Ding Shi-Jin , Bao Wen-Zhong , Zhou Peng , Zhang David Wei
Published: January 2021

Flexible low-power consumption BN-based memristors have the integrated capabilities of digital memcomputing and analogue neuromorphic computing.
Correction: Recent advances in integration of 2D materials with soft matter for multifunctional robotic materials
Authors: Jing Lin , Li Kerui , Yang Haitao , Chen Po-Yen
Published: January 2021

Correction for ‘Recent advances in integration of 2D materials with soft matter for multifunctional robotic materials’ by Lin Jing et al., Mater. Horiz., 2020, 7, 54–70, DOI: 10.1039/C9MH01139K.
High-performance tricolored white lighting electroluminescent devices integrated with environmentally benign quantum dots
Authors: Han Chang-Yeol , Yoon Suk-Young , Lee Sun-Hyoung , Song Seung-Won , Jo Dae-Yeon , Jo Jung-Ho , Kim Hyun-Min , Kim Hyun-Sik , Yang Heesun
Published: January 2021

Tricolored white lighting quantum dot-light-emitting diodes comprising three environmentally benign primary color emitters of II–VI blue and green ZnSeTe and I–III–VI red Zn–Cu–In–S QDs are demonstrated.
Origin of layer-dependent SERS tunability in 2D transition metal dichalcogenides
Authors: Li Mingze , Gao Yimeng , Fan Xingce , Wei Yunjia , Hao Qi , Qiu Teng
Published: January 2021

Exploring the influence of interlayer interaction on SERS performance by using 2D PtSe2 and ReS2 with different numbers of layers as the research objects.
Atomic-scale imaging of the growth and transformation of Pt3Ni–NiO nanoparticles
Authors: Zhang Junyu
Published: January 2021

The evolution of Pi3Ni–NiO nanoparticles was visualized in a liquid cell.
Construction of hollow ZnO/Mn-ZIF-67 heterojunction photocatalysts: enhanced photocatalytic performance and mechanistic insight
Authors: Liu Nannan , Shang Simin , Shi Dajun , Cheng Qingrong , Pan Zhiquan
Published: January 2021

Thanks to the unique structure and properties of MOFs, a well-designed novel hollow ZnO/Mn-ZIF-67 composite photocatalyst was synthesized by a facile sonocrystallization approach successfully.
A novel green synthesis of silver nanoparticles by the residues of Chinese herbal medicine and their biological activities
Authors: Wei Simin , Wang Yinghui , Tang Zhishu , Xu Hongbo , Wang Zhe , Yang Tian , Zou Taiyan
Published: January 2021

A novel method for green synthesis of medicinal AgNPs has been developed by using the residues of Chinese herbal medicine.
Effect of the valence state of Mn in MnOx/Ti4O7 composites on the catalytic performance for oxygen reduction reaction and oxygen evolution reaction
Authors: Bai Fan , Xu Lincheng , Wang Daode , An Li , Hao Zhanzhong , Li Fan
Published: January 2021

Manganese oxide composites with mixed valence states were prepared by compositing with Ti4O7 and calcination temperature could influence their ORR and OER catalytic performance observably.
Sign inversion in magnetic circularly polarised luminescence of fused aromatics with 1.6 T N-up/S-up Faraday geometry
Authors: Toda Hayato , Hara Nobuyuki , Fujiki Michiya , Imai Yoshitane
Published: January 2021

Diamagnetic fused aromatics exhibit mirror-symmetric magnetic circularly polarised luminescence (MCPL) depend on either the aromatic structures or the peripheral positions of the substituents through N-up and S-up Faraday geometries under a 1.6 T magnetic field.
Rapid growth of the CH3NH3PbCl3 single crystal by microwave irradiation
Authors: Sektiono Moch Wisnu Arif , Permatasari Fitri Aulia , Aimon Akfiny Hasdi , Iskandar Ferry
Published: January 2021

We report a rapid growth of the CH3NH3PbCl3 single crystal through microwave irradiation.
Electrical conductivity and dielectric properties of Sr doped M-type barium hexaferrite BaFe12O19
Authors: Marouani Y. , Massoudi J. , Noumi M. , Benali A. , Dhahri E. , Sanguino P. , Graça M. P. F. , Valente M. A. , Costa B. F. O.
Published: January 2021

The hexaferrite Ba1−xSrxFe12O19compounds withx= 0, 0.5 and 1 were synthesized by the autocombustion method.
Amino acid ester-coupled caffeoylquinic acid derivatives as potential hypolipidemic agents: synthesis and biological evaluation
Authors: Zhang Xi , Liu Dong-yun , Shang Hai , Jia Yi , Xu Xu-Dong , Tian Yu , Guo Peng
Published: January 2021

Amino acid ester-coupled caffeoylquinic acid derivatives as potential hypolipidemic agents.
Concerted dispersion of Staphylococcus aureus biofilm by bacteriophage and ‘green synthesized’ silver nanoparticles
Authors: Manoharadas Salim , Altaf Mohammad , Alrefaei Abdulwahed Fahad , Devasia Rajesh Mamkulatil , Badjah Hadj Ahmed Yacine M. , Abuhasil Mohammed Saeed Ali
Published: January 2021

Formation of biofilm by Staphylococcus aureus ‘Rumba’ on untreated glass surface and a concerted disruption of the biofilm by silver nanoparticle and phage ϕ44AHJD.
MoC nanodots toward efficient electrocatalytic hydrogen evolution: an interlayer-confined strategy with a 2D-zeolite precursor
Authors: Gao Boxu , Huang Yanghuan , Wang Sinong , Lu Haiyang , Zheng Luyao , Fan Xueliang , Yang Xue , Zhang Wenbiao , Wang Yajun , Zhang Yahong , Gao Qingsheng , Tang Yi
Published: January 2021

An ultrafine MoC nanodot electrocatalyst with superior HER performance is obtained through an interlayer-confined strategy with a 2D-zeolite precursor.
Band restructuring of ordered/disordered blue TiO2 for visible light photocatalysis
Authors: Oh Simgeon , Kim Ji-Hee , Hwang Hee Min , Kim Doyoung , Kim Joosung , Park G. Hwan , Kim Joon Soo , Lee Young Hee , Lee Hyoyoung
Published: January 2021

We performed a band modulation of the phase-selectively disordered rutile P25 TiO2 and disordered anatase P25 TiO2 and their band structures were confirmed by transient absorption spectroscopy.
Efficient nitrogen reduction to ammonia by fluorine vacancies with a multi-step promoting effect
Authors: Wang Zuochao , Wu Xueke , Qin Yingnan , Han Yi , Zhang Dan , Zhao Huan , Chi Jingqi , Xu Guangrui , Wang Minghui , Li Shaoxiang , Wang Dan , Lai Jianping , Wang Lei
Published: January 2021

A new fluoride vacancy of tradition metal material (FV-LaF3-x nanosheets) is rationally designed and synthesized by sodium borohydride reduction at room temperature, which improves the nitrogen reduction performance due to multi-step promotion.
Experiences of Social Distancing During Coronavirus Disease 2019 as a Catalyst for Changing Long-Term Care Culture
Authors: Leaman Marion C. , Azios Jamie H.
Published: January 2021

Purpose

In this article, we draw a parallel between the experience of social isolation that occurred throughout the world during the Coronavirus Disease 2019 pandemic and similar experiences occurring in everyday life for people with communication disorders living in long-term care (LTC) facilities. We propose that speech-language pathologists can use the widespread experience of social isolation as a learning catalyst in the effort to shift the LTC culture to one that more highly values a communicative environment that is accessible to all, thereby reducing risk of social isolation for those with communication disorders.

Conclusions

Many training paradigms for promoting an accessible communicative environment are available in the speech-language pathology literature, yet institutional barriers exist for their widespread implementation. Overcoming these barriers is a challenge that requires awareness and learning on the part of staff and administration regarding the impact of an unfriendly communicative environment on social isolation, and the resulting psychosocial consequences. Learning theory indicates that new learning in adults is motivated by connections between personal experiences and the material to be learned. Explicitly infusing established training programs with the experience of social isolation brought on by the Coronavirus Disease 2019 pandemic may be the key needed for changing the communicative environment in LTC.
Cognitive Processing of Miscommunication in Interactive Listening: An Evaluation of Listener Indecision and Cognitive Effort
Authors: Roche Jennifer M. , Zgonnikov Arkady , Morett Laura M.
Published: January 2021

Purpose

The purpose of the current study was to evaluate the social and cognitive underpinnings of miscommunication during an interactive listening task.

Method

An eye and computer mouse–tracking visual-world paradigm was used to investigate how a listener's cognitive effort (local and global) and decision-making processes were affected by a speaker's use of ambiguity that led to a miscommunication.

Results

Experiments 1 and 2 found that an environmental cue that made a miscommunication more or less salient impacted listener language processing effort (eye-tracking). Experiment 2 also indicated that listeners may develop different processing heuristics dependent upon the speaker's use of ambiguity that led to a miscommunication, exerting a significant impact on cognition and decision making. We also found that perspective-taking effort and decision-making complexity metrics (computer mouse tracking) predict language processing effort, indicating that instances of miscommunication produced cognitive consequences of indecision, thinking, and cognitive pull.

Conclusion

Together, these results indicate that listeners behave both reciprocally and adaptively when miscommunications occur, but the way they respond is largely dependent upon the type of ambiguity and how often it is produced by the speaker.
Longitudinal Changes in Auditory and Cognitive Function in Middle-Aged and Older Adults
Authors: Humes Larry E.
Published: January 2021

Purpose

This article aimed to document longitudinal changes in auditory function, including measures of temporal processing, and to examine the associations between observed changes in auditory and cognitive function in middle-aged and older adults.

Method

This was a prospective longitudinal study of 98 adults (66 women) with baseline ages ranging from 40 to 85 years. The mean interval between T1 baseline and T2 follow-up measurements was 8.8 years with a range of 7–11 years. Measures of hearing threshold, gap detection, and auditory temporal-order identification were completed at T1 and T2. Cognitive measures completed at T1 and T2 were the 13 scales of the Wechsler Adult Intelligence Scale–Third Edition. Three approaches were taken to analyze these data: (a) examination of changes over time in group performance, (b) correlations and slopes between auditory and cognitive measures to examine concomitant
rates
of decline over the 9-year T1-to-T2 period, and (c) regression analyses examining associations between auditory performance at T1 and cognitive performance 9 years later at T2.

Results

For the group data, there were significant declines in hearing loss, gap-detection thresholds at one frequency, and process-type measures of cognitive function from T1 to T2 matching the trends in the baseline cross-sectional data. Regression analyses of the longitudinal data revealed the strongest connection between auditory temporal-order processing and cognitive processing typically explaining 10%–15% of the variance.

Conclusions

A significant amount of variance in rates of cognitive decline, T1 to T2, and subsequent cognitive performance (T2) was explained by measures of auditory function. Although hearing loss occasionally emerged as a significant factor, auditory temporal-order identification emerged much more frequently as the auditory measure most strongly associated with cognitive function.
Quality of service (QoS) for LTE network based on adaptive neuro fuzzy inference system
Authors: Nafea Hala B. , Aboelezz Zeinab A. , Zaki Fayez W.
Published: January 2021

The main objective of this paper is to design an Adaptive Neuro Fuzzy Inference System model to calculate the quality of service for LTE HetNet applications. The quality of service parameters considered are delay, loss rate, throughput, and jitter. The adaptive neuro fuzzy inference system is an integration of fuzzy logic and neural network. The advantage of neural network in adaptive neuro fuzzy inference system is to train the neural network algorithm on the parameter values of membership function for fuzzy logic to construct fuzzy decision. So, adaptive neuro fuzzy inference system gives better performance than fuzzy logic alone for LTE network applications (e.g. VOIP, HTTP, VIDEO, and EMAIL). The results based on adaptive neuro fuzzy inference system model produce high quality of service for LTE network applications as compared with fuzzy logic alone. It is also found that adaptive neuro fuzzy inference system results in EMAIL and quality of service outperform fuzzy logic alone by about 28.7% at medium delay, low loss rate, jitter, and high throughput.
Multi‐antenna joint covert communication with a public communication link over wireless fading channel
Authors: Lin Yuda , Jin Liang , Huang Kaizhi , Zhou You
Published: January 2021

This paper studies multi‐antenna covert communication exploiting a public communication link over the wireless fading channel. In particular, a relatively practical covert communication scenario is considered for the first time, where a warden with radiometer may improve its detection accuracy by jointly detecting uplink covert pilot and downlink covert communication. To this end, a joint covert communication system, jointly considering uplink covert pilot, imperfect channel state information issue and downlink covert communication, is proposed and further studied. Specifically, the detection performance of warden and the covertness performance of system are comprehensively studied, respectively. Afterwards, an optimization problem for covert capacity is formulated to maximize overall performance. Then, with our analysis and simplification, an optimal power allocation algorithm is designed for covert capacity accordingly. Our examination shows a win‐win situation has been achieved in the proposed system, that is, covert communication would rarely affect the normal communication of public link and occupy its communication resources. Interestingly enough, we analytically find an invariance property of downlink covert communication that covertness performance is not impacted by noise levels or warden's position. Based on this extraordinary finding, we conclude that the downlink covert communication system can perfectly combat with a powerful warden adopting power trend test method, while the joint covert communication system may resist that through a pilot deception scheme.
Toward Cosmicflows-4: The HI data catalog
Authors: Dupuy A. , Courtois H. M. , Guinet D. , Tully R. B. , Kourkchi E.
Published: January 2021

Aims. In this study, we present an update of a compilation of line width measurements of neutral atomic hydrogen (HI) galaxy spectra at 21 cm wavelength. Our All Digital HI (ADHI) catalog consists of the previous release augmented with our new HI observations and an analysis of archival data. This study provides the required HI information to measure the distances of spiral galaxies through the application of the Tully-Fisher (TF) relation.

Methods. We conducted observations at the Green Bank telescope (GBT) and reprocessed spectra obtained at the Nançay radiotelescope by the Nançay Interstellar Baryons Legacy Extragalactic Survey and Kinematics of the Local Universe collaborations and we analyzed the recently published full completion Arecibo Legacy Fast ALFA (ALFALFA) 100% survey in order to identify galaxies with good quality HI line width measurements.

Results. This paper adds new HI data adequate for TF use for 385 galaxies observed at GBT, 889 galaxies from archival Nançay spectra, and 1515 rescaled Arecibo ALFALFA spectra. In total, this release adds 1274 new good quality measurements to the ADHI catalog. Today, the ADHI database contains 18 874 galaxies, for which 15 433 have good quality data for TF use. The final goal is to compute accurate distances to spiral galaxies, which will be included in the next generation of peculiar velocities catalog: Cosmicflows-4.
Singular perturbations and optimal control of stochastic systems in infinite dimension: HJB equations and viscosity solutions
Authors: Święch Andrzej
Published: January 2021

We study a stochastic optimal control problem for a two scale system driven by an infinite dimensional stochastic differential equation which consists of “slow” and “fast” components. We use the theory of viscosity solutions in Hilbert spaces to show that as the speed of the fast component goes to infinity, the value function of the optimal control problem converges to the viscosity solution of a reduced effective equation. We consider a rather general case where the evolution is given by an abstract semilinear stochastic differential equation with nonlinear dependence on the controls. The results of this paper generalize to the infinite dimensional case the finite dimensional results of Alvarez and Bardi [SIAM J. Control Optim.40(2001/02) 1159–1188] and complement the results in Hilbert spaces obtained recently in Guatteri and Tessitore [To appear in:Appl. Math. Optim.(2019)https://doi.org/10.1007/s00245-019-09577-y].
Using of artificial neural networks to assess the residual resource of trunk pipelines
Authors: Lapiga Ilya , Shchipachev Andrey , Osadchiy Dmitriy
Published: January 2021

A large number of oil and gas pipelines in the Russian Federation have been in operation for over 20 years. For these pipelines, the issue of assessing the residual resource is relevant. Today, much attention is paid to the problem of long-term durability of pipelines. Trunk pipelines are under the influence of cyclic loads and influences arising during operation. The acting stresses in the pipe wall do not exceed the allowable ones, however, they cause micro-damage to the metal structure. When assessing the cyclic fatigue of a metal, the main criterion is the relative damage to the metal. The use of non-destructive testing methods (ultrasonic and magnetic), as well as the establishment of a relationship between the number of cycles and diagnostic parameters, will improve the accuracy of the residual life assessment. When analyzing several diagnostic parameters, the question of data interconnection becomes relevant. Since establishing an empirical or semi-empirical relationship between ultrasonic and magnetic properties is a complex task, artificial neural networks (ANNs) can be used to solve this problem. The use of ANN in the diagnostics of trunk pipelines will increase the accuracy of the assessment and eliminate the subjectivity of data interpretation.
Improving Margins of the Indonesian Seaweed Supply Chain Upstream Players: The application of the Kaizen Approach
Authors: Heri Purnomo Agus , Kusumawati Rinta , Pratitis Asri , Alimin Ilham , Wibowo Singgih , Rimmer Mike , Paul Nick
Published: January 2021

The margin obtained at the upstream in the Indonesian commercial seaweed supply chain is generally small and makes the motivation for business development low. The research aimed to identify the opportunities to overcome these problems. The research conducted with the Kaizen analysis approach that seven upstream business nodes were chosen at three locations: two Gracilaria sp. farmers and one Gracilaria sp. trader in Brebes, one Eucheumatoid farmer and one intermediary trader in Serang, also two Eucheumatoid farmers in Sumenep. The results show some inefficiency in several loci in the business lines of intermediate farmers and traders. These include a gap on moisture content (Gracilaria of 2 % and Eucheumatoid of 4 %), productivity of Gracilaria pond 0.6 t ha–1 yr–1 and its by-product is 50 %, while the productivity of Eucheumatoids was 10 %. The quality of dry Gracilaria is one grade only. All result loss of potential margin. Root problem analysis found several external factors outside the Kaizen domain and other internal aspects can be corrected through intervention. The Kaizen analysis determined some simple interventions including improvement of cultivation embankments and extension of maintenance periods, use of monofilament net to dry seaweed, optimization of cultivation spacing, and use of moisture checker.
Detergents Effect on Egg Hatchability, Morphometry and Larval Bone Structure of Native Indonesian Fish: Wader Pari (Rasbora lateristriata Bleeker, 1854)
Authors: Umi Abida Farahsani , Alam Parvez , Retnoaji Bambang
Published: January 2021

This study was conducted to determine the effect of detergents on eggs hatchability, survival rates, morphometry and bone structure of Wader Pari fish (Rasbora lateristriata Bleeker, 1854). The fish were treated with detergent solution, with a concentration of 0 mg L−1, 3 mg L−1, 6 mg L−1, 9 mg L−1, 18 mg L−1, 27 mg L−1, and 50 mg L−1, respectively. Each test consisted of one aquarium filled with 30 eggs. The number of eggs hatched was counted and these were treated continually for 1.5 mo to determine fish survival rates, morphology, growth rates and bone structure assays. The bone structure assay was prepared with Alizarin’s Red-Alcian Blue staining. The results show that detergent treatments at 0 mg L−1, 3 mg L−1, 6 mg L−1, 9 mg L−1 did not significantly affect hatchability, survival rate, or morphometry of either egg or fish (p > 0.05). However, a higher concentration at 18 mg L−1, 27 mg L−1, and 50 mg L−1, significantly affected the fish egg hatchability and survivability. Moreover, fish vertebral structures were normal at treatments of 0 mg L−1, 3 mg L−1, 6 mg L−1, whereas at 9 mg L−1, was caused abnormal vertebral structures.
Factors that Influence Farmer’s Behavior Towards Risk
Authors: Nurdin Yusuf Muhamad , Yuniawan Isyanto Agus , Sudradjat Sudradjat
Published: January 2021

The research was carried out with the aim to find out the behavior of farmers towards risk and the factors that influence it. The research sample was 100 paddy farmers in flood-prone area paddy fields in Pangandaran District, West Java Province, Indonesia. Farmer’s behavior towards risk was analyzed using quadratic utility functions, while the factors that influence farmer’s behavior towards risk were analyzed using logistic regression. The results showed farmers 87 was risk neutral, while 13 farmer risk takers were farmers. Education, familys size and income significantly influence farmer’s behavior towards risk; while age, experience, land area, production risk, price risk, income risk and group did not significantly influence farmer’s behavior towards risk.
Risk Analysis of Partnership Broiler Farm in Blitar District, East Java, Indonesia
Authors: Nur Wulan Mulatmi Septi , Devi Anggraini Apriliana , Shaywont Pratami Febrianti , Motalova Martina
Published: January 2021

Contract farming is a form of business cooperation between two or more parties in a certain period of time to help farmers provide production facilities. The superiority of the partnership is as a partner to share the risk burden of production between core companies and small farmers. The risk of production in broiler chicken farming includes DOC quality, feed, and disease. Therefore, production risk management must be able to manage these factors well so they cannot cause losses. The material in this research is thirty partnership farmers in Blitar, East Java, Indonesia. The method used is a survey by observation and interview. The sources of data used are primary and secondary data sources from the results of interviews and observations. The analysis used is production risk analysis to determine the level of production risk in Blitar, East Java, Indonesia and descriptive analysis to find out the production risk management used by partnership farmers in Blitar, East Java, Indonesia. The results of this study can be concluded that the risk of production in Blitar, East Java, Indonesia is categorized as high risk caused by death. Meanwhile, production risk management carried out by farmers in Blitar, to reduce mortality is spraying disinfectants.
The Use of Rumen Contents as Bio–Activators for Fermentation in Goat Manure Fertilizer Production
Authors: Pancapalaga Wehandaka , Suyatno Suyatno , Sedlacek David
Published: January 2021

Slaughterhouse waste cause environmental problems. Rumen content comprise a lot of enzymes of potential bacteria as bio–activators in the process of making goat manure fertilizer. The study aimed to evaluate the quality of goat manure fertilizer added with rumen content. The materials used were goat manure and cattle rumen contents. The research method uses a Completely Randomized Designed (CRD). The percentages of cattle rumen contents treatments i.e. 0 %, 5 %, 10 % and 15 %. The variables measured were Nitrogen (N), Phosphor (P), Potassium (K), Carbon organic, C/N ratio and moisture content. The results showed, the addition of rumen contents had a very significant effect (p < 0.01) on C organic, P, N, and C/N, but had no significant (p > 0.05) on K and moisture content. The results showed that the best treatment was addition of 15 % rumen, that had N 1.59 %, P 0.15 %, K 0.72 %, C organic 30.60 %, C/N 19.24 %, and moisture content 45.86 %. This content had fulfilled SNI 19–7030–2004 for goat manure fertilizer. It could be concluded that giving rumen contents could increase N, P, K, C organic and decrease C/N and moisture content.