bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical and blood gas characteristics of mycoplasmal pleural effusion and tuberculous pleural effusion in pediatric patients: a retrospective case-control study
Authors: Chen Li , Shang Yunxiao , Cai Xuxu , Cheng Qi
Published: April 2022

Background
Mycoplasma pneumoniae pneumonia-related pleural effusion (MP-PPE) and tuberculous pleural effusion (TPE) are common pediatric respiratory diseases. This study aimed to investigate their clinical characteristics, serum markers, and pleural fluid characteristics in pediatric patients.
Methods
The clinical and imaging characteristics, serum inflammatory indicators, pleural fluid analysis, and biochemistry and blood gas analysis results from 98 children aged 2–14 years who were hospitalized in the Pediatric Respiratory Department of Shengjing Hospital of China Medical University from 2018 to 2021 for MP-PPE or TPE were retrospectively examined.
Results
There were 28 (40%) males and 44 (60%) females in the MP-PPE group and 18 (69%) males and 8 (31%) females in the TPE group (p < 0.05). There was no statistically significant between-group difference in the age ranges of the MP-PPE group (2–13 years, mean age 7.55 ± 3.29 years) and TPE group (5–14 years, mean age 9.69 ± 3.70 years) (p > 0.05). The duration of fever before admission was 12.54 ± 6.95 and 7.77 ± 4.00 days in the MP-PPE and TPE groups, respectively (t = 2.324, p < 0.05). The duration of cough before admission was 15.04 ± 6.86 and 5.90 ± 4.81 days in the MP-PPE and TPE groups (t = 3.972, p < 0.05). Serum neutrophil percentage and C-reactive protein, procalcitonin, interleukin-6, lactate dehydrogenase (LDH), D-dimer, and alanine transaminase levels were significantly higher in the MP-PPE group than in the TPE group. CD3+, CD3 + CD8+, CD3 + CD4+, CD16 + CD56+, and CD19 + counts were lower in the MP-PPE group. There were significant between-group differences in white blood cell count and hemoglobin, fibrinogen, and immunoglobulins (IgA, IgM, and IgG) levels (p > 0.05). There was no significant between-group difference in adenosine deaminase level (p > 0.05). Finally, while there were significant between-group differences in pleural fluid pH, PaCO2, and pleural fluid lactate and blood gas glucose levels (p < 0.05), there was no significant between-group difference in pleural fluid PaO2 (p > 0.05).
Conclusions
Serum and pleural fluid LDH levels were elevated in the MP-PPE group compared to the TPE group. Our findings could be used to help distinguish MP-PPE from TPE. Blood gas analysis results revealed that the MP-PPE group had a higher pH and was predominantly alkaline compared with the TPE group, which is also a significant finding for differentiating MP-PPE from TPE.
Causal impact of physical activity on child health and development
Authors: Nguyen Ha , Christian Hayley , Le Huong , Connelly Luke , Zubrick Stephen , Mitrou Francis
Published: April 2022

The relationship between physical activity and child health and development is well-documented, yet the extant literature provides limited causal insight into the amount of physical activity considered optimal for improving any given health or developmental outcome. This paper exploits exogenous variations in local weather conditions observed across random time use diary dates for the same individuals over time to investigate the causal impact of physical activity on a comprehensive set of health, non-cognitive development, and academic outcomes of children and adolescents. Applying an individual fixed-effects instrumental variables model to a nationally representative panel dataset from Australia, we find that physical activity leads to widespread benefits in child development. These include improved health, social and emotional development, and lower health expenditure. The results further indicate that physical activity offers greater developmental benefits for females. However, we find no evidence that physical activity improves academic performance. Our study highlights that the “optimal” amount of time that children and adolescents should spend physically active each day varies by the health or non-cognitive development outcome of interest. The results are robust to a series of specification and sensitivity tests, including an over-identification test and controlling for weather conditions recorded on the day when development outcomes were assessed.
Deciphering the Prognostic Implications of T Cells Marker Genes Signature in the tumor Microenvironment of Hepatocellular Carcinoma
Authors: Jiang Chenyu , Liang Jiangmin , Wang Yiwan , Wang Chaohui , Wei Shenyu , Ni Junjie , Shao Yaojian
Published: April 2022

Background: Hepatocellular carcinoma is one of the most aggressive gastrointestinal tumor, with a high recurrence and mortality rate. Novel immunotherapy targeting the tumor microenvironment are innovative and promising therapeutic approaches for some tumor, including hepatocellular carcinoma. However, patr of patients with HCC remain a diminished response to immunotherapy on account of the insufficient understanding on the tumor microenvironment. Methods: The correlation between infiltrated immune cells and hepatocellular carcinoma patients prognosis were confirmed via MCP-counter algorithms. The single-cell RNA sequencing dataset (GSE146115) was performed to identify T cells marker genes in hepatocellular carcinoma. GSE10141, GSE14520 dataset and TCGA-liver hepatocellular carcinoma were used to construct and validate the T cell marker genes signature (TCMS).Results: The survival analysis revealed the correlation between infiltrating T cells and the overall survival of patients with hepatocellular carcinoma. Four T cell marker genes included in the TCMS model were: HELZ, GZMA, SLC2A2, JAK3. The TCMS risk score could stratify patients with hepatocellular carcinoma into high- and low-risk score subgroups. TCMS risk score remained a influential feature of overall survival and one of the independent prognostic risk factors in multivariate analysis in TCGC validation cohort. Besides, correlation analysis indicated increased expression of HELZ, GZMA and JAK3 were significantly correlated with high degree of CD8+ T cell, CD4+ T cell infiltration.Conclusion: We successfully constructed the T cell marker genes signature with powerful predictive function and provided a new understanding of T cell infiltration in tumor microenvironment which might offer practices instructions for HCC immunotherapy.
WITHDRAWN: Different Storage Conditions Affects Microbial Profiles in Chicken Cecal Chyme and Lung
Authors: Yang Jiajun , Wang Jing , Zhang Bo , Qin Shunyi , Zhang Hao , Liu Guofang
Published: April 2022

Background: Storage conditions are as an important influence on accurate analysis of deoxyribonucleic acid based microbial communities in metagenomic studies. In this study, fresh chicken pulmonary and cecal samples were prepared and stored in −20 °C, −80°C and liquid nitrogen (−147°C) for 7days. The total 16 ribosomal deoxyribonucleic acid was extracted and measured with next generated sequencing of the V3-4 region gene to compare frequently-used storage conditions on the quality and composition of the fecal microbial community.Results: Total microbial composition in fresh pulmonary samples were more abundant than those stored in -80°C for 7days in total OUT number, and the composition at phylum level were richer than those stored in -20 °C, -80°C and -147°C. The phylum of campilobacteria, proteobacteria, bacteroidota, and actinobacteriota were significant higher. Result of α diversity showed there were no differences on microbial number at genus level. While, abundances of microbial composition varied, the mainly distinct genus bacteroides, rikenellaceas_RC9, clostrida_vadinBB60, norank_f_norank_o_rhodospirllales, norank_f_ barnesiellaceae. Results of microbial composition in fresh cecal chyme suggested that the genus of bacteroides, megasphaera, norank_f_ruminococcaceae, helicobacter, and norank_f_ norank_o_gastranaerophilales are richer than all other groups, while the genus of sphingomonas, norank_f_ norank_o_SJA－15 were lower than those of others. The OTU number in fresh cecal chyme was higher than those stored in -147°C, while there were no differences with -20°C and -80°C. Also, microbial composition at phylum level were no significant differences between fresh and others in cecal chyme. Number of differential microbial in both pulmonary and cecal samples stored in -80°C and -147°C were little compared with those in fresh and -20°C suggested with LEfSe linear discriminant analysis.Conclusion: Samples of lung and cecal chyme for 16S r DNA sequencing stored in -20°C for 7 days can induce to microbial colonization, which were not accurate in interpreting data. In -80°C and -147°C introduce declined tendencies in post-collection compared with fresh samples.
Prevalence, Pattern and Predictors of Intimate Partner Violence Amongst Female Undergraduates in Abia State, Nigeria; Public Health Implications
Authors: Odini Franklin Ndubuisi , Amuzie Chidinma Ihuoma , Kalu Kalu Ulu , Emma-Ukaegbu Uloaku , Nwamoh Uche Ngozi , Izuka Michael , Odini Uchechukwu Vivian , Ezepue Chukwubuike Obiora
Published: April 2022

Background:
Intimate Partner Violence (IPV) is the range of sexually, psychologically and physically coercive acts used against adult and adolescent women by a current or former male partner. It is a major public health problem globally. This study determined the prevalence, patterns and predictors of IPV amongst female undergraduates in Abia State.
Methods
A cross-sectional study was conducted from January - February 2022 amongst 306 female undergraduates in Abia State. A mixed method of an online structured questionnaire created on Google forms & onsite self-administered questionnaire were deployed for data collection. Descriptive, bivariate and multivariate analyses were done using IBM SPSS Version 26.0. The level of significance was set at 5%.
Results
A total of 306 respondents participated in the survey. The overall prevalence of IPV amongst female undergraduates was 51.2% (95% CI: 44.8%-57.6%). Emotional abuse was the most common form of abuse 78.9%, followed by Physical abuse 42.0% and Sexual abuse 30.8%. Predictors of IPV reported include female earning/receiving more than their partner monthly(aOR = 2.30; 95% CI: 1.20–4.41); male (partner) alcohol consumption(aOR = 5.17; 95% CI: 2.46–10.88), being a smoker of cigarette/marijuana(aOR = 11.01; 95% CI: 1.26–96.25) and having witnessed domestic violence as a child(aOR = 3.55; 95% CI: I.56-8.07).
Conclusion
Over half of all female undergraduates in Abia State have experienced IPV with emotional abuse being the commonest. Some Individual and relationship factors were identified as predictors of IPV. We recommend intensifying primary prevention campaigns against risk factors identified like smoking and alcohol consumption.
Are greener start-ups of superior quality? The impact of environmental orientation on innovativeness, high-growth, and internationalisation.
Authors: Neumann Thomas
Published: April 2022

This paper merges the literature on green and high-quality entrepreneurship by introducing environmental orientation as an unrecognised characteristic of start-up quality and the three quality dimensions innovativeness, high-growth, and internationalisation. Entrepreneurship literature argues that only high-quality start-ups contribute to sustainable development and that a better understanding of what determines the quality of start-ups is required. Empirical research has recently shown that the environmental orientation of start-ups is one such determinant, as it significantly predicts their innovativeness. This paper pursues this novel research avenue on the importance of environmental orientation for start-up quality in two ways. First, this paper evaluates and extends this initial evidence on environmental orientation and innovativeness by examining a three times larger sample, covering additional countries and entrepreneurial stages. Second, this paper also analyses the impact of environmental orientation on the quality dimensions of high-growth and internationalisation. Investigation using Global Entrepreneurship Monitor data on 9,650 entrepreneurs from 51 countries revealed that start-ups with a higher environmental orientation are of superior quality regarding their innovativeness, growth expectations, and exports. These results remain robust for start-ups at different entrepreneurial stages, and tests employing different methodological approaches and variable definitions. However, the categorisation into factor-driven, efficiency-driven, and innovation-driven countries showed that greener start-ups are more innovative in countries at all three levels of development, while the relationships with high-growth and internationalisation remained significant for only two of the three categories. The findings of this paper provide a new approach for practitioners to identify the small number of high-quality start-ups and an economic reason warranting intensified efforts to support green start-ups.
LncRNA SNHG1 facilitates the epithelial-mesenchymal transition and invasiveness in glioblastoma multiforme via regulation of the miR-128- 3p/RRAS2 axis
Authors: Wang Yongqiang , Li Qi , Yang Xiaochen , Zhang Weidong , Zhou Runpeng , Su Zhenjin , Wan Hengtong , Hong Xinyu
Published: April 2022

Purpose The present study aimed to identify the role of long non-coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) in the progression of glioblastoma multiforme (GBM) and the regulatory mechanism of the SNHG1/miR-128-3p/RRAS2 network. Methods The TargetScan method was used to analyze the target mRNAs and associated miRNAs of SNHG1. The levels of SNHG1, miRNAs, and mRNAs were determined in glioma and normal brain tissues based on The Cancer Genome Atlas. Pathway analysis was used to identify the significant pathways of the predicted target genes of SNHG1 according to the Kyoto Encyclopedia of Genes and Genomes. The expressions of SNHG1 in GBM cells were determined by real-time quantitative polymerase chain reaction (qRT-PCR). A scratch wound-healing and Transwell assays were used to determine GBM cell migration and invasion. The dual-luciferase reporter assay was used to validate the miR-128-3p target relationships with lncRNA SNHG1. Western blotting was performed to determine whether SNHG1 and RRAS2 regulated the epithelial-mesenchymal transition (EMT) process of GBM cells. Results SNHG1 was upregulated in glioma tissues and cells. Knockdown of SNHG1 inhibited migration and invasion of GBM cells. A competing endogenous RNA interaction network of SNHG1-6miRNAs-17mRNAs was constructed and revealed the functional role of the SNHG1/miR-128-3p/RRAS2 feed-forward loop. MiR-128-3p expression was downregulated in glioma tissues, whereas RRAS2 expression was elevated in glioma tissues. QRT-PCR and dual luciferase reporter analyses of the results indicated that SNHG1 bound to miR-128-3p, while SNHG1 expression was negatively regulated by miR-128-3p. Additionally, miR-128-3p regulated the expression of RRAS2 mRNA. Moreover, knockdown of RRAS2 inhibited GBM cell migration and invasion. Collectively, SNHG1 promoted GBM progression by sponging miR-128-3p and regulating RRAS2 expression. In addition, down-regulations of SNHG1 and RRAS2 significantly reduced the expressions of mesenchymal markers, N-cadherin and vimentin, while it increased the protein level of E-cadherin epithelial marker, showing that silencing SNHG1 reversed the EMT phenotype. Conclusion Our findings confirmed that lncRNA SNHG1 promoted the malignant progression of GBM by the SNHG1/miR-128-3p/RRAS2 axis, which activated the EMT process. The SNHG1/miR-128-3p/RRAS2 axis therefore may provide a novel therapeutic treatment for GBM.
The Value of Oral Examinations and the Role it Plays in Medical Student Education
Authors: Wu Emily , Larson Stephanie , Chacko-Stacey Alexandra , Lynch James C. , Hart Elaine , Siddighi Sam
Published: April 2022

Background: Medical education has a long history of using structured oral examinations (SOE) to evaluate trainee aptitude for high-order processing. However, the SOE has received substantial criticism in recent years regarding limited reliability, possibility of bias and high cost. Methods: In this randomized control trial, 214 third year medical students rotating through the OB/GYN clerkship were divided into two groups, those who took the SOE (n=112) and those who did not (n=102). The mean scores of two required clerkship examinations, the Observed Standardized Clinical Examination (OSCE) and the National Board of Medical Examiners (NBME) subject exam, were compared between the SOE and the non-SOE groups.Results: We found no difference between group mean NMBE scores (SOE group: 75.6%, SD: 7.951 | non-SOE group: 73.9%, SD: 8.302 | p = 0.698) and actually found that those who did not participate in the SOE out-performed those who did in the OSCE (SOE group: 72.8%, SD: 4.978 | non-SOE group: 76.3%, SD: 5.331| p = 0.002). Discussion: Our results suggest that the implementation of the SOE in clerkship curriculum does not correlate with improved medical student performance or success.
DNA Content Estimation in the Genus Salvia
Authors: Maynard Rebekah C.I. , Ruter John M.
Published: April 2022

Salvia is a genetically diverse genus in the Lamiaceae family, with hundreds of species distributed globally. With base chromosome numbers ranging from 6 to 19 and ploidy levels ranging from diploid to octoploid, the genus has been proposed to be subdivided based on molecular data rather than morphology. However, little is known about total DNA content across the genus. The DNA content of 141 Salvia genotypes were analyzed using flow cytometry. Samples of Salvia were stained with propidium iodide and compared with the internal standards Pisum sativum ‘Ctirad’ and Solanum lycopersicum ‘Stupické’ to generate estimations of DNA content. Holoploid 2C genome sizes of the analyzed Salvia ranged from 0.63 pg to 6.12 pg. DNA content showed a wide distribution across chromosome number, ploidy, and clade. The wide distribution of DNA content across the genus further indicates the diversity of Salvia and may be useful for future breeding efforts.
Legal Protection of Investors from the Corporate Malfeasance of Insider Dealings: A South African-Canadian Comparative Review
Authors: Oluyeju M. , Oluyeju O.
Published: April 2022

Ensuring market discipline, integrity, and transparency with the overall aim of protecting the investing public is critical to the wellness of a capital market and a financial system. However, one corporate ill besetting the securities markets in all jurisdictions is insider trading. Apart from being unethical, insider trading disrupts market dynamics. In South Africa, over the years, successive Acts have been enacted, amended, and repealed to ensure discipline and protect the integrity of the nation’s securities market. In 2012, the Financial Markets Act of 2012 (FMA) was enacted to improve, among others, the enforcement of insider trading regulation in South Africa. However, the regulation of insider trading and its enforcement in terms of the FMA have been insufficient. This article therefore seeks to benchmark the South African position against Canadian model with the objective of drawing lessons for South Africa. The choice of Canada was informed by the fact that Canada has a well-developed anti-insider trading regulatory framework and presents a case study of international best practices in the regulation of insider trading. Therefore, the conclusion in this article is that with creative and appropriate reforms of the FMA, using the Canadian model, the investing public will be adequately protected against insider trading, and investors’ confidence and the financial markets’ integrity and efficiency will be better enhanced.
BRICS Countries’ Economic and Legal Cooperation Through the Prism of Strategic Planning Documents
Authors: Shaidullina V. , Semenovskiy I.
Published: April 2022

The purpose of this article is to identify the core trends in economic and legal cooperation among the BRICS countries through the prism of strategic documents and normative acts adopted to define national development benchmarks in certain economic sectors. The authors carried out an analysis of strategic and policy documents adopted by Brazil, Russia, India, China and South Africa with a view to developing certain sectors of the national economy. It is pointed out that international cooperation is now considered necessary to achieve sustainable economic growth. The relevance of the research topic is dictated by the need to determine and develop approaches to improve the legal fundamentals of economic cooperation among the BRICS countries, as well as to prepare proposals for their implementation. The analysis of national programs and development priorities of the economies of the BRICS member countries has shown that the programs of Russia and China are the most comprehensive. Brazil’s development priorities, the socio-economic development policy of India and South Africa’s national development plan are primarily aimed at overcoming the problems inherent in these countries. Among the main areas of interest for all of the BRICS countries are agriculture, digital economy, energy, environment, education and health, finances, labour and employment, infrastructure and transportation and trade. Cooperation among the BRICS countries is likely to develop mainly through the exchange of experiences and best practices, joint research and realization of specific economic projects supervised by executive authorities, central banks and other state bodies. An important institution for economic interaction between the BRICS countries is the New Development Bank; other successful mechanisms of economic cooperation include the Contingent Reserve Arrangement, the Energy Research Cooperation Platform and the Partnership on New Industrial Revolution.
Human-Centered Design Approaches in Digital Mental Health Interventions: Exploratory Mapping Review
Authors: Vial Stéphane , Boudhraâ Sana , Dumont Mathieu
Published: April 2022

Background

Digital mental health interventions have a great potential to alleviate mental illness and increase access to care. However, these technologies face significant challenges, especially in terms of user engagement and adoption. It has been suggested that this issue stems from a lack of user perspective in the development process; accordingly, several human-centered design approaches have been developed over the years to consider this important aspect. Yet, few human-centered design approaches to digital solutions exist in the field of mental health, and rarely are end users involved in their development.

Objective

The main objective of this literature review is to understand how human-centered design is considered in e-mental health intervention research.

Methods

An exploratory mapping review was conducted of mental health journals with the explicit scope of covering e-mental health technology. The human-centered design approaches reported and the core elements of design activity (ie, object, context, design process, and actors involved) were examined among the eligible studies.

Results

A total of 30 studies met the inclusion criteria, of which 22 mentioned using human-centered design approaches or specific design methods in the development of an e-mental health solution. Reported approaches were classified as participatory design (11/27, 41%), codesign (6/27, 22%), user-centered design (5/27, 19%), or a specific design method (5/27, 19%). Just over half (15/27, 56%) of the approaches mentioned were supported by references. End users were involved in each study to some extent but not necessarily in designing. About 27% (8/30) of all the included studies explicitly mentioned the presence of designers on their team.

Conclusions

Our results show that some attempts have indeed been made to integrate human-centered design approaches into digital mental health technology development. However, these attempts rely very little on designers and design research. Researchers from other domains and technology developers would be wise to learn the underpinnings of human-centered design methods before selecting one over another. Inviting designers for assistance when implementing a particular approach would also be beneficial. To further motivate interest in and use of human-centered design principles in the world of e-mental health, we make nine suggestions for better reporting of human-centered design approaches in future research.
Transfer Validity of Pediatric Supracondylar Humeral Fracture Pin Placement Practice on In-Theater Performance by Orthopedic Trainees Using an Augmented Reality Simulator: Protocol for a Pilot Interventional Cohort Study With a Retrospective Comparator Cohort (Preprint)
Authors: Guo Joyce , Blyth Phil , Clifford Kari , Hooper Nikki , Crawford Haemish
Published: April 2022

BACKGROUND

Supracondylar humeral fractures (SCHF) are a common cause of orthopedic morbidity in pediatric populations across the world. The treatment of this fracture is likely one of the first procedures involving x-ray–guided wire insertion that trainee orthopedic surgeons will encounter in their career. Traditional surgical training methods of “see one, do one, teach one” are reliant on the presence of real-world cases and must be conducted within an operative environment. We have developed an augmented reality simulator that allows trainees to practice this procedure in a radiation-free environment at no extra risk to patients.

OBJECTIVE

This study aims to examine whether training on a simulator in addition to traditional surgical training improves the in-theater performance of trainees.

METHODS

This multicenter, interventional cohort study will involve orthopedic trainees from New Zealand in their first year of advanced training between 2019 and 2023. Advanced trainees with no simulator exposure who were in their first year in 2019-2021 will form the comparator cohort, while those in the years 2022-2023 will receive additional regular simulator training as the intervention cohort. The comparator cohort’s performance in pediatric SCHF surgery will be retrospectively audited using routinely collected operative outcomes and parameters over a 6-month period. Data on the performance of the intervention cohorts will be collected in the same way over a comparable period. The data collected for both groups will be used to determine whether additional training with an augmented reality training shows improved real-world surgical outcomes compared to traditional surgical training.

RESULTS

As of February 2022, a total of 8 retrospective comparator trainees have been recruited by email. The study is financially supported through an external grant from the Wishbone Orthopaedic Research Foundation of New Zealand (September 2021) and an internal research grant from the University of Otago (July 2021).

CONCLUSIONS

This protocol has been approved by the University of Otago Health Ethics committee (reference HD21/087), and the study is due for completion in 2024. This protocol may assist other researchers conducting similar studies in the field.

CLINICALTRIAL

Australian New Zealand Clinical Trials Registry ACTRN12623000816651; https://tinyurl.com/mtdkecwb

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/38282
Peran Guru Dalam Meningkatkan Karakter Disiplin Untuk Mewujudkan Ketahanan Pribadi Siswa Melalui Pembelajaran PPKn (Studi Kasus Di SMA 1 Wonreli Maluku Barat Daya)
Authors: Salouw Joniel Hendrik , Suharno Suharno Suharno , Talapessy Rostin
Published: April 2022

ABSTRACTThe purpose of this study was to revealed the role of the teacher in improving the character of discipline in order to realized students' personal resilience through learning Pancasila and Citizenship Education at SMA 1 Wonreli. student personal resilience. This research was a case study with a qualitative approach. This research was conducted in SMA 1 Wonreli Maluku Barat Daya (MBD). Data collection techniques in this study used three methods, namely, observation, interviews, and documentation. The results of this study were 1) The role of teachers in enhancing the character of discipline to created student personal resilience was the right way to instilled character values in the younger generation in order to created a generation with character and integrity. 2) Teachers always emphasized students to be disciplined and had good personalities in facing challenges and obstacles that weakened personal resilience, arriving at school on time, not cheating, wearing uniforms according to prescribed rules, obeying in words and actions. 3) In improving the character of discipline to created student personal resilience or fostering student character was the main alternative in producing students who were in accordance with the values of Pancasila.ABSTRAKTujuan penelitian ini adalah untuk mengungkapkan peran guru dalam meningkatkan karakter disiplin demi untuk mewujudkan ketahanan pribadi siswa melalui pembelajaran Pendidikan Pancasila dan Kewarganegaraan di SMA 1 Wonreli, Kendala apa saja yang di hadapi dalam menigkatkan karakter disiplin siswa, upaya yang digunakan dalam menigkatkan disiplin siswa untuk mewujudkn ketahanan pribadi siswa.Penelitian ini merupakan studi kasus dengan pendekatan kualitatif. Penelitian ini dilaksanakan di sekolah SMA 1 Wonreli Maluku Barat Daya (MBD). Teknik pengumpulan data dalam penelitian ini mengunakan tiga cara yaitu, observasi, wawancara, dan dokumentasi.Hasil dari penelitian ini adalah 1) Peran guru dalam meningkatkan karakter disiplin untuk mewujudkan ketahanan pribadi siswa merupakan cara yang tepat untuk menanamkan nilai-nilai karakter pada generasi muda demi untuk menciptakan generasi yang berkarakter dan berintegritas. 2) Guru selalu menekankan kepada siswa untuk berdisiplin dan berkepribadian baik dalam menghadapi tantangan dan hambatan yang melemahkan ketahanan pribadi, datang di sekolah tepat waktu., tidak mencontek, memakai seragam sesuai aturan yang ditentukan, taat dalam perkataan dan tindakan. 3) Dalam meningkatkan karakter disiplin untuk mewujudkan ketahanan pribadi siswa atau membina karakter siswa merupakan alternatif utama dalam menghasilkan peserta didik yang sesuai dengan nilai-nilai Pancasila.
Rekonstruksi Keamanan Maritim Indonesia Dalam Rangka Mewujudkan Ketahanan Wilayah (Studi Di Kabupaten Natuna Periode Tahun 2019-2020)
Authors: Suwarno Panji , Sumantri Siswo Hadi , Bahar Fauzi
Published: April 2022

ABSTRACT                  There were several things that were important points for Indonesia by paying attention to several things, firstly, Indonesia must be aware of the security situation in the North Natuna Sea, which was often disputed by several regional countries. Conflicts in regional areas would affect security because geographically, Indonesia was very close to this area and even directly in contact with the North Natuna Sea. The conflict would also have an impact on economic conditions, because the Natuna sea area was the crossing area of international ships that were going to industrial areas, including Indonesia. The purpose of this article was to analyzed the threats and reconstruct Indonesia's maritime security in the context of realizing national resilience. The case study of this research was on the Natuna sea conflict. This research used descriptive qualitative data analysis techniques. Based on the analysis, the threat analysis had been seen through response management against the form of violation in the Natuna sea area, by Bakamla RI, Lanal, Lantamal, and the Regional Government, also the Central Government through the Ministry of Foreign Affairs. This could be used as a form of development (reconstruction) for Indonesian Maritime Resilience in order to provided support for national resilience to strengthened national defense. ABSTRAK Terdapat beberapa hal yang menjadi poin penting bagi Indonesia dengan memperhatikan beberapa hal yaitu pertama, Indonesia harus mewaspadai situasi keamanan di Laut Natuna Utara yang sering terjadi sengketa oleh beberapa negara kawasan. Konflik di daerah kawasan akan mempengaruhi keamanan karena secara geografis wilayah Indonesia sangat berdekatan dengan wilayah tersebut dan bahkan bersinggungan langsung dengan wilayah Laut Natuna Utara. Konflik juga akan berimbas dengan kondisi ekonomi, dikarenakan wilayah laut Natuna merupakan perlintasan internasional kapal-kapal yang hendak berlayar menuju wilayah industrial termasuk Indonesia. Artikel ini bertujuan menganalisis ancaman dan rekontruksi kemanan maritim Indonesia dalam rangka mewujudkan ketahanan nasional.Studi kasus penelitian ini pada konflik perairan Natuna. Penelitian ini menggunakan teknik analisis data kualitatif deskriptif.Berdasarkan analisis, analisis ancaman sudah terlihat melalui manajemen respon terhadap bentuk pelanggaran di wilayah periaran Natuna, oleh Bakamla RI, Lanal, Lantamal dan Pemerintah Daerah, serta Pemerintah Pusat Melalui Kementerian Luar Negeri. Hal inilah yang dapat dijadikan sebagai bentuk bangunan (rekonstruksi) terhadap Ketahanan Maritim Indonesia guna memberikan dukungan terhadap ketahanan nasional untuk memperkuat pertahanan negara.
Ketahanan Wilayah Kabupaten Karimun Dalam Menghadapi Pandemi Covid-19
Authors: Budiman Diky , Kapiarsa Asa Bintang
Published: April 2022

This research will open up a new discussion regarding the resilience of a region in facing the Covid-19 Pandemic. Aim of this researcher is to depict vulnerability of the region towards pandemic Covid-19. The analysis of this research uses a descriptive qualitative approach with spatial identification and literature review. From the literature review, there are 5 factors of defense geography that can be used to identified regional vulnerability, which are secure location, topographical depression, population density, land use and distribution of health services. Based on the results obtained, it is known that there are some regions that have Tinggi vulnerability and yet still struggling in facing the Pandemic Covid-19 such as Karimun and Kundur. But there are also regions that have Tinggi vulnerability but can push down the spreading such as Moro, Durai,Meral, Meral Barat and Tebing Subdistricts. Some other regions that have Sedang and Rendah vulnerability also can deal with pandemic very well.
Driving the innovation process by connecting regional knowledge bases to local needs
Authors:   Leiden University. Centre for Science and Technology Studies, Mena Jara Sonia Daniela , Meijer Ingeborg , Heimeriks Gaston , Willemse Tim
Published: April 2022

Novel approaches are needed to support the creation of more open, inclusive, and self-sustaining R&I ecosystems in healthcare. This study analysed 3 European regions (Murcia ES), (Örebro SE), and (Republic of Cyprus CY), incorporating complementary approaches from Responsible Research and Innovation (RRI) and Research and Innovation Smart Specialisation Strategy (RIS3). The exercise entailed the identification of healthcare and innovation stakeholders and the characterisation of the policy landscape in each territory. Moreover, the strengths of the regional knowledge base was analysed by measuring the Revealed Comparative Advantage (RCA) indicator based on relatedness measurement, and by using micro-level fields analyses of scientific publications. This methodology allowed us to identify the fields and topics (strengths) that provide opportunities for innovation processes. Additional identification of social needs in the three territories showed profound differences regarding the alignment of the selected needs with respect to the regions’ capabilities. The results suggest that a timely direct interaction with territorial stakeholders can help in selecting the most promising innovation priorities that are based on local needs and knowledge. The process of interaction requires early engagement to support territorial ownership and is further reinforced by RRI policies in place.
ESTRUCTURA DE LA COMUNIDAD DE AVES DEL MUNICIPIO DE ÁLAMO TEMAPACHE, VERACRUZ
Authors: Maldonado Apolonio Jesús , Gutiérrez Peña Maciel Alejandra , Sotomayor Betancourt Alan Axel , García-Collazo Rodolfo
Published: April 2022

Los ecosistemas naturales han sufrido cambios significativos en su estructura provocando que la avifauna se adecue a las condiciones ambientales modificadas. El municipio de Álamo Temapache, Veracruz ha tenido la impronta de áreas agroforestales y ganaderas disminuyendo la vegetación natural. El objetivo del presente estudio es conocer la estructura de la comunidad aviar en un mosaico de cinco tipos de hábitat en el municipio. Se muestreó de enero de 2015 a enero de 2016 en puntos de conteo y con redes de niebla. El listado de especie se completó con registros en eBird. Se registraron 177 especies; las especies endémicas representaron 29% del estado de Veracruz. El 13% de las especies se encuentran incluidas en la NOM-059 de la SEMARNAT; 3.4% están amenazadas de acuerdo con la UICN, mientras que 7.3% se encuentran con alto grado de vulnerabilidad. Se registra la ampliación en la distribución en el estado de las especies Sarcoramphus papa, Columbina minuta, Pseudoscops clamator y la presencia en el estado de Glaucidium sanchezi. Predominan las especies residentes (59.3%), el índice de diversidad es alto y similar entre la sequía y lluvias. La mayor riqueza específica y valor de índice de diversidad se presentó en dos zonas: cultivo de frutales y en cuerpos de agua con vegetación riparia, y la menor en pastizales. En el municipio se presenta una mezcla de mosaicos de vegetación implantada y fragmentos de vegetación original, esta heterogeneidad permite una alta riqueza de especies y diversidad aviar en el municipio.
Analysis of the mental model about the atom concept in Spanish 15- to 18- years old students
Authors: Cascarosa Salillas Esther , Pozuelo Muñoz Jorge , Jiménez Mercedes , Fernández Álvarez Francisco J.
Published: April 2022

The present research investigates the mental models about the atom of Spanish 15- to 18- years old students. A sample of 454 students was taken into account within a representative Spanish context. A specific questionnaire, validated before students solved it, where the students should draw, define and argue was designed. It has been found that most of the students understand the atom as a mix of several models. In general, the models they mix are those that they studied during their last educational course. Some students possess a unique mental model about the atom (Bohr´s model), and a really few students described the atom as it could be expected according to their educational level. Several reasons have been appointed among them are: i) the construction of a mental model is a hard and slow process, even more in the case of the atom, ii) this is a complex concept which requires abstraction and to use spatial knowledge in very young students, and iii) teachers offer to students few situations to check their mental models, and thus, it takes so much time to find the strengths and weaknesses of their models.
Mitocondrias en el cerebro y sus alteraciones en la Enfermedad de Alzheimer
Authors: Arias Alvarez Clorinda , Espino de la Fuente Muñoz César
Published: April 2022

Las mitocondrias son consideradas como una red mitocondrial donde se producen numerosos eventos de fusión y fisión, en las que el transporte y degradación están altamente regulados. En el cerebro, las mitocondrias y los procesos involucrados en su dinámica son importantes para sostener funciones neuronales y alteraciones en su función e integridad pueden contribuir al daño sináptico en enfermedades relacionadas con la edad como la Enfermedad de Alzheimer. En esta revisión mostramos un panorama acerca de las funciones mitocondriales en el cerebro y en los procesos de plasticidad neuronal, y hacemos énfasis en la evidencia que existe en relación con la disfunción de las mitocondrias en pacientes y en modelos de la enfermedad de Alzheimer.
Hardware Monitoring Suite
Authors: Padwal Saumil , Shukla Vaibhav , Pawar Mayur , Prajapati Vikas , Adivarekar Prof. Pravin , Malve Prof. Sachin
Published: April 2022

Abstract: Hardware Monitoring Suite is a system monitoring app which will be used for tracking of hardwarecomponents such as CPU (temperatures, voltages), fan speeds, Core temperature, system hardware detection , PSU load, among others. In addition, it will also provide suggestion of better components than the current components, as well as news about latest hardware for upgrades.
Survey paper on Garbage Collection Management System
Authors: Rao K. Aditya , D Dr. Ganesh
Published: April 2022

Abstract: Smart cities integrate multiple mobile or websolutions to build a comfortable human habitation. One of these solutions is to provide an environmentally friendly, efficient and effective garbage management system. The current garbage collection system includes routine garbage trucks doing roundsdaily or weekly, which not only doesn't cover every zone of the city but its completely inefficient use of government resources. The proposed system, where admin manage the garbage app for full online based mointoring and analyze the system. Her admin handle bins, driver, complaints from user and work report from driver. This paper proposes a cost-effective mobile or web based system for the government to utilize available resources to efficiently manage the over whelming amounts of garbage collected each day, while also providing a better solution for the inconvenience of garbage disposal for the citizens. This is done by a driver, app will provide predictive and guide routes generated through for garbage trucks. Then driver update the status of work done will be data collected. An android or web app is developed for the work force and the citizens, which primarily provides the user create complatints available smart bin.
Psikoedukasi pola hidup bersih sehat pada siswa di lingkungan Rumah Belajar Kakek Aboe, Malang
Authors: Putra Dimas Setyadi
Published: April 2022

COVID-19 is a disease caused by SARS-CoV-2, as of March 24, 2022 in Indonesia, a total of 5,986,830 confirmed positive patients and 3,266 people came from East Java. Knowledge and actions from the public regarding PHBS are able to reduce the number of COVID-19 cases so that it will accelerate the end of a pandemic. Knowledge is the forerunner of behavior which is the main reason or motivation for a person to behave. This service was carried out on 27 July – 09 September 2020 through an educative approach in the form of exposure to COVID-19 transmission material, good hand washing, proper use of masks and other Clean and Healthy Lifestyles (PHBS). Questionnaires were used to measure students' knowledge. It is known that there was an increase in the average score from the pretest of 8.63 to 8.93, which means that there was an increase in students' knowledge in Rumah Belajar Kakek Aboe after being given education
Psikoedukasi mengenai stunting pada anak dan peran pengasuhan orangtua untuk meningkatkan pengetahuan mengenai stunting
Authors: Rachmah Dwi Nur , Zwagery Rika Fira , Azharah Bunga , Azzahra Fatimah
Published: April 2022

Parenting patterns will determine how parents behave in preventing and overcoming stunting. Community service in the form of psychoeducation through online seminars (webinar) is considered necessary to provide understanding and knowledge to parents about stunting and the role of parents in child care to prevent and overcome stunting. Psychoeducation activities are carried out through webinars due to the Covid-19 pandemic conditions which make it impossible to gather in one place. This psychoeducation activity was attended by 88 participants consisting of housewives, working mothers and teenagers. The selection of participants was done by distributing activity posters and contacting several PAUDs. The effectiveness of psychoeducational activities is seen through an open questionnaire given to participants before and after the implementation of the activity. An open questionnaire in the form of questions that participants must answer descriptively to see the participants' responses to the implementation of psychoeducation. The results obtained from psychoeducational activities through this webinar showed that participants found this activity useful and provided new knowledge about stunting, especially parenting
Peran Harga, Promosi, dan Kualitas Produk Dalam Mendorong Keputusan Pembelian Kembali di Bale Ayu Denpasar
Authors: Yudiana I Made , Indiani Ni Luh Putu
Published: April 2022

Bidang usaha pengolahan kayu merupakan salah satu bidang usaha di Bali dengan tingkat kompetisi cukup ketat. Bale Ayu salah satu perusahaan yang bergerak di bidang pengolahan bahan mentah kayu menjadi barang jadi, yang merupakan objek penelitian ini, mengalami penurunan pencapaian target secara konsisten setiap tahun. Hal ini mencerminkan adanya permasalahan pada minat konsumen untuk membeli atau membeli kembali. Hal ini melatarbelakangi penelitian ini untuk menganalisis faktor-faktor yang mendorong minat konsumen untuk melakukan pembelian kembali. Penelitian ini bertujuan untuk menganalisis pengaruh harga, promosi, dan kualitas produk terhadap keputusan pembelian kembali di Bale Ayu. Populasi dalam penelitian ini adalah pelanggan Bale Ayu sejumlah 190 orang. Metode pengumpulan data adalah metode survey dengan kuesioner. Teknik analisis regresi linier berganda digunakan untuk menguji pengaruh variabel bebas terhadap variabel dependen. Hasil penelitian menemukan bahwa harga, promosi, dan kualitas produk berpengaruh positif dan signifikan terhadap keputusan pembelian kembali. Aspek-aspek yang perlu diperhatikan untuk meningkatkan kualitas kebijakan harga adalah: menetapkan harga yang kompetitif, terjangkau, memberikan potongan harga, dan menawarkan berbagai opsi pembayaran (cash/debit/kredit). Aspek-aspek yang perlu diperhatikan untuk meningkatkan kualitas promosi adalah: mempromosikan produk melalui iklan di berbagai media, memberikan potongan harga berupa diskon, dan mempublikasikan produk melalui berbagai program seperti pameran, pemasaran afiliasi, dsb. Aspek-aspek yang perlu diperhatikan untuk meningkatkan kualitas produk adalah: memastikan produk berfungsi dengan baik, memperhatikan kesesuaian produk dengan spesifikasi yang disampaikan, menjaga daya tahan produk agar tahan lama, menghasilkan produk dengan tampilan menarik, dan menjaga kualitas produk.
Analisis Dampak Kebijakan Restrukturisasi Kredit Terhadap Laba dan Likuiditas BPR di Kabupaten Badung
Authors: Kustina Ketut Tanti , Suryawan I Gede Merta Nugrahita , Utari I Gusti Ayu Diah
Published: April 2022

Tujuan penelitian ini adalah untuk mengetahui ada atau tidaknya pengaruh kebijakan restrukturisasi kredit OJK terhadap perbankan yang diverminkan dengan perbedaan yang signifikan terhadap laba dan likuiditas sebelum dan sesudah kebijakan. Restrukturisasi kredit merupakan langkah untuk memberi keringanan angsuran kredit bank atau pinjaman leasing bagi debitur atau peminjam yang usaha dan pekerjaannya terkena dampak langsung atau tidak langsung pandemi COVID-19. Jenis penelitian ini adalah kuantitatif dengan bentuk penelitian studi peristiwa dan dengan menggunakan populasi seluruh BPR yang berada di Provinsi Bali. Pengambilan sampel penelitian menggunakan purposive sampling. Metode analisis data yang digunakan adalah uji beda (uji paired sample t-test). Berdasarkan hasil penelitian ini menunjukkan bahwa terdapat adanya perbedaan yang signfikan terhadap laba sebelum dan sesudah kebijakan restrukturisasi kredit OJK yang artinya kebijakan restrukturisasi kredit OJK sebagai upaya antisipasi COVID-19 berpengaruh signifikan terhadap perbankan.
JAPAN'S MORTGAGE MARKET: THE "SOAP BUBBLE" OF THE 1980S AND ITS CONSEQUENCES
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Светлана Алексеевна Литвинова
Published: April 2022

Статья посвящена рассмотрению вопроса развития ипотечного жилищного кредитования в Японии. Рассматривается структура рынка ипотечного кредитования Японии и этапы его развития. Констатируется, что ипотечный рынок Японии отражает традиционные черты японской экономической модели: патернализм, социальную ориентацию и, одновременно, динамизм развития.