bluuebunny/crossref_metadata_2025 huggingface dataset:
Combined action of albumin and heparin regulates lipoprotein lipase oligomerization, stability, and ligand interactions
Authors: Risti Robert , Gunn Kathryn H. , Hiis-Hommuk Kristofer , Seeba Natjan-Naatan , Karimi Hamed , Villo Ly , Vendelin Marko , Neher Saskia B. , Lõokene Aivar
Published: April 2023

Lipoprotein lipase (LPL), a crucial enzyme in the intravascular hydrolysis of triglyceride-rich lipoproteins, is a potential drug target for the treatment of hypertriglyceridemia. The activity and stability of LPL are influenced by a complex ligand network. Previous studies performed in dilute solutions suggest that LPL can appear in various oligomeric states. However, it was not known how the physiological environment, that is blood plasma, affects the action of LPL. In the current study, we demonstrate that albumin, the major protein component in blood plasma, has a significant impact on LPL stability, oligomerization, and ligand interactions. The effects induced by albumin could not solely be reproduced by the macromolecular crowding effect. Stabilization, isothermal titration calorimetry, and surface plasmon resonance studies revealed that albumin binds to LPL with affinity sufficient to form a complex in both the interstitial space and the capillaries. Negative stain transmission electron microscopy and raster image correlation spectroscopy showed that albumin, like heparin, induced reversible oligomerization of LPL. However, the albumin induced oligomers were structurally different from heparin-induced filament-like LPL oligomers. An intriguing observation was that no oligomers of either type were formed in the simultaneous presence of albumin and heparin. Our data also suggested that the oligomer formation protected LPL from the inactivation by its physiological regulator angiopoietin-like protein 4. The concentration of LPL and its environment could influence whether LPL follows irreversible inactivation and aggregation or reversible LPL oligomer formation, which might affect interactions with various ligands and drugs. In conclusion, the interplay between albumin and heparin could provide a mechanism for ensuring the dissociation of heparan sulfate-bound LPL oligomers into active LPL upon secretion into the interstitial space.
The perceived barriers and facilitators for chiropractic care in older adults with low back pain; insights from a qualitative exploration in a dutch context
Authors: De la Ruelle Lobke P. , de Zoete Annemarie , Myburgh Cornelius , Brandt Hella E. , Rubinstein Sidney M.
Published: April 2023

Background

Understanding care seeking behaviour is vital to enabling access to care. In the context of low back pain (LBP), chiropractors offer services to patients of all ages. Currently, geriatric sub-populations tend to be under-investigated, despite the disproportionate effects of LBP on older adults. In the Netherlands, the chiropractic profession is relatively unknown and therefore, generally speaking, is not considered as the first choice for conservative musculoskeletal primary health care. The aim of this paper was to explore the experiences of older adults with LBP, seeking chiropracic care for the first time, in order to identify perceived barriers and facilitators in this process.

Methods

Stage 1: Participants 56 years of age and older with chronic LBP who either sought or did not seek chiropractic care were interviewed to provide detailed information on the factors that promoted or impeded care-seeking behaviour. A purposive sampling strategy was used to recruit participants through a network of researchers, chiropractors and other healthcare professionals offering musculoskeletal health care services. Individuals with underlying pathology, previous surgery for LBP, or insufficient mastery of the Dutch language were excluded. Data were collected until saturation was reached and thematically analysed. Stage 2: To further explore the themes, a focus group interview was conducted with a provider stakeholder group consisting of:two physiotherapists, a nurse practitioner, a geriatrician, and a chiropractor. All interviews were conducted online, voice recorded, and transcribed verbatim.

Results

We interviewed 11 older adults with low back pain. During this process four themes emerged that captured their perception and experiences in either seeking or dismissing chiropractic care for their LBP; these being ‘generic’, ‘financial’, ‘expectation’, and ‘the image of the chiropractor’. The focus group members largely confirmed the identified themes, highlighting a lack of awarenes and accessibility as key barriers to care. On the other hand, whe chiropractior as an alternative care provider, with a focus on manual interventions, was seen as a facilitator.

Conclusions

The lack of knowledge about chiropractic care was found to be the most important barrier to seeking care. The most important facilitator was insufficient resolution of their symptoms following previous care, making patients look further for a solution for their problem. These barriers and facilitators seem not to differ greatly from barriers and facilitators found among younger patients with neck pain. Age and health condition may therefore be weak determinants of care. This new information may help us optimize accessibility for older adults to the chiropractor.
Decreased tourism during the COVID-19 pandemic positively affects reef fish in a high use marine protected area
Authors: Weng Kevin C. , Friedlander Alan M. , Gajdzik Laura , Goodell Whitney , Sparks Russell T.
Published: April 2023

Humans alter ecosystems through both consumptive and non-consumptive effects. Consumptive effects occur through hunting, fishing and collecting, while non-consumptive effects occur due to the responses of wildlife to human presence. While marine conservation efforts have focused on reducing consumptive effects, managing human presence is also necessary to maintain and restore healthy ecosystems. Area closures and the tourism freeze related to the COVID-19 pandemic provided a unique natural experiment to measure the effects of decreased tourism on fish behavior in a high use no-take marine protected area (MPA) in Hawai`i. We found that when tourism shut down due to COVID restrictions in 2020, fish biomass increased and predatory species increased usage of shallow habitats, where tourists typically concentrate. When tourism resumed, fish biomass and habitat use returned to pre-pandemic levels. These displacement effects change fish community composition and biomass, which could affect key processes such as spawning, foraging and resting, and have knock-on effects that compromise ecosystem function and resilience. Managing non-consumptive uses, especially in heavily-visited MPAs, should be considered for sustainability of these ecosystems.
Re-use of laboratory utensils reduces CO2 equivalent footprint and running costs
Authors: Farley Martin , Nicolet Benoit P.
Published: April 2023

Laboratory-based research is resource intensive in terms of financial costs and its carbon footprint. Research laboratories require immense amounts of energy to power equipment, as well as large volumes of materials, particularly of single-use item consumption. In fact, many laboratories have essentially become reliant on single-use plastics. Understanding the full carbon footprint of consumable usage is increasingly important as many research institutes commit to carbon neutrality. To date, no carbon footprint assessment has been conducted to detail the differences between single-use plastics, and reusable glass in a laboratory setting. Here, we analyse the CO2 equivalent (CO2e) footprint of utilising single-use plastics, and re-use of glass or plastic items within laboratory environments. We focused our assessment on four commonly utilised consumables for mammalian cell and bacterial culture, and found that re-use scenarios resulted in substantial reduction in CO2e footprint up to 11-fold. In addition, we estimated the long-term financial costs of re-use and single-use scenarios, and found that re-use had either similar or much lower running costs even when including technical staff wage. We concluded that research facilities must foster re-use in laboratory consumables, while reserving single-use items for select, defined cases. Our study highlights the need to account for indirect CO2e footprint in designing a carbon-neutral lab and promotes circular economy principles.
Disposition effect and reference points: An experimental study
Authors: da Costa Newton , Paraboni Ana Luiza , Goulart Marco
Published: April 2023

This study calls into question the default computation of the disposition effect that uses the average purchase price as a reference point. We show, through a lab experiment, that the reference price of participants can change depending on the experimental behavioral design that is used. Our results show that for the control group, different reference prices do not show significant differences in the computation of the disposition effect, thus supporting the use of the average purchase price as a reference. However, this is not the case for participants in the treatment group. With the addition of experimental treatment concerning the disclosure of the final balance of the participants, the reference prices to compute the disposition effect showed statistically significant differences. The need to display their results caused these participants to use the first purchase price as a reference point when selling their assets.
Study on the damage resistance and deterioration behavior of GO concrete under the harsh environment
Authors: Chen Chengqin , Zhang Wei , Wu Hongjuan , Chen Chenggui , Ma Bin
Published: April 2023

To exploretheeffects of physical, mechanical, anti-deterioration properties of graphene oxide (GO) on cement-based cementitious materials, GO sheet dispersions areprepared by the improved Hummers method and ultrasonic dispersion method. The influence of theGO content on the compressive and flexural strengths of cement paste is investigated, and the penetration process of chloride ions in graphene oxide concrete is discussed by the electric accelerated erosion method. Combined with the rapid freeze-thaw test, the deterioration of graphene oxide concrete ismethodically analyzed. Theobtained results reveal that an appropriate amount of GO improves both the compressive and flexural strengths of cement pastev. In the chloride environment, the chloride diffusion coefficient of 0.03% GO concrete is 18.75% less than that of ordinary concrete.Under the action of freeze-thaw cycles, with the increase of salt freezing times, the deterioration mode of GO concrete is a combination of mortar shedding, micro-crack expansion, denudation, and block shedding; The stress-strain curve of the specimen tends to be flat with the growth of salt freezing times. The peak stress gradually lessens, the peak strain gradually grows, and the elastic modulus remarkably reduces. Compared with ordinary cement paste, theGO is capable of promoting the growth of cement paste hydration crystals, changing the size and shape of crystals, and realizingthe regulation of cement paste microstructure. Incorporating an appropriate amount of theGO could promote the cement hydration process and enhance the chemical water-binding amount in the cement paste. The optimal GO content is reported to be 0.03% of the cement mass.
Health and social care workers experiences of coping while working in the frontline during the COVID-19 pandemic: One year on
Authors: Soubra Karina , Tamworth Camilla , Kamal Zeast , Brook Clare , Langdon Dawn , Billings Jo
Published: April 2023

Background

The unprecedented pressure of working on the frontline during the Covid-19 pandemic had a demonstrable impact on the mental health and wellbeing of health and social care workers in the early stages of the pandemic, however, less research has focused on workers’ experiences over the longer course of the pandemic.

Aims

We set out to develop an explanatory model of the processes that helped and hindered the coping of HSCWs working over the course of the Covid-19 pandemic.

Method

Twenty HSCWs based in the UK took part in the study. They completed semi-structured interviews 12–18 months after the peak of the first wave in the UK. Interviews were transcribed and analysed using grounded theory methodology.

Results

The analysis identified eleven theoretical codes: personal context, organisational resources, organisational response, management, colleagues, decision-making and responsibilities, internal impacts, external impactors, safety, barriers to accessing support and temporal factors. The findings suggest that factors related to the individual themselves, their personal context, the organisation they work in, their managers, the support structures around them and their sense of safety impacted on HSCWs; ability to cope. Some factors changed over time throughout the first year of the pandemic, such as workload and staff illness, which further impacted HSCWs’ coping. There were many barriers to accessing support that also impacted coping, including availability, awareness and time. The relationship between the factors that impacted coping are represented in an explanatory model.

Conclusions

The findings extend previous studies on the mental health impact on frontline HSCWs working during Covid-19, providing novel insight by developing an explanatory model illustrating the underlying factors that impacted their coping experiences over the course of the pandemic in the UK. The findings from this study may assist in the development of improved and more effective support for HSCWs going forwards.
Association between visual impairment and risk of suicide: Protocol for a systematic review and meta-analysis
Authors: Kim Chung Young , Ha Ahnul , Shim Sung Ryul , Chang In Boem , Kim Young Kook
Published: April 2023

Introduction

Suicide is an important public health problem. Well-established risk factors of suicide include depression, family history of mental disorders, substance problem, chronic physical illness, and others. Sensory impairment, especially visual impairment (VI), has a critical impact on both mental and physical health. However, the association between VI and risk of suicide has not been thoroughly investigated and remains controversial. Our aim is to systematically review and meta-analyze the current evidence on the association between VI and risk of suicide and to evaluate the direction and magnitude of the association.

Methods and analysis

We aim to search PubMed, EMBASE and the Cochrane Library to identify all population-based studies on the association between VI and risk of suicide. Two reviewers will independently conduct study selection, data extraction and risk of bias (ROB) assessment. The Newcastle-Ottawa scale will be applied to evaluate the methodologic quality of the included studies for ROB assessment. The primary outcome measure will be the relative risk (RR) of suicide, and the secondary outcome measures will be the risks of suicidal ideation (SI) and suicide attempt (SA). Estimates of risk with 95% confidence intervals (CIs) for suicide, SI and SA, respectively, will be calculated and summarized. We will perform random-effects meta-analyses to combine the pooled effects. Meta-regression will be applied to investigate the effects of multiple factors across studies. Subgroup and sensitivity analyses will be conducted for screening of any potential sources of heterogeneity. Publication bias will be evaluated by funnel plot and Begg and Mazumdar correlation testing. The body of evidence will be assessed using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach.

Conclusion

This article presents a study protocol for investigating the association between VI and risk of suicide. The findings of this study will contribute to our current knowledge of the impact of VI as a risk factor of suicide. In addition, meta-regression and subgroup analyses will provide further insights to factors affecting the association between VI and suicide risk.

Trial registration

Systematic review registration:PROSPEROCRD 42022325106.
An exploration of trolling behaviours in Australian adolescents: An online survey
Authors: Marrington Jessica Z. , March Evita , Murray Sarah , Jeffries Carla , Machin Tanya , March Sonja
Published: April 2023

To understand why people “troll” (i.e., engage in disruptive online behaviour intended to provoke and distress for one’s own amusement), researchers have explored a range of individual differences. These studies have primarily been conducted in adult samples, despite adolescents being a particularly vulnerable group with regards to both being trolled and trolling others. In this study we aimed to (1) explore Australian adolescents’ experiences of trolling, and (2) replicate adult research that has constructed a psychological profile of the Internet troll by examining the utility of personality traits (psychopathy and sadism), self-esteem, empathy (cognitive and affective), and social rewards (negative social potency) to predict adolescents’ trolling behaviours. A sample of 157 Australian adolescents (40.8% male, 58% female, 0.6% non-binary) aged 13–18 years (M = 15.58, SD = 1.71) completed the Global Assessment of Internet Trolling-Revised, Adolescent Measure of Empathy and Sympathy, Rosenberg Self-Esteem Scale, Youth Psychopathy Traits Inventory-Short Version, Social Rewards Questionnaire, Short Sadistic Impulse Scale, and a series of questions related to the experience of trolling. Results showed in the past year, 24.2% of Australian adolescents reported being trolled and 13.4% reported having trolled others. Gender, psychopathy, sadism, self-esteem, cognitive empathy, affective empathy, and “negative social potency” (i.e., enjoyment of antisocial rewards) combined, explained 30.7% of variance in adolescents’ trolling behaviours (p < .001). When accounting for shared variance, gender (male), high psychopathy, and high negative social potency were significant predictors of trolling, aligning with findings of adult samples. Contrary to adult samples, sadism was not a unique predictor of adolescents’ trolling. For adolescents, the variance in trolling explained by sadism was nonsignificant when controlling for negative social potency. These similarities, and differences, in predictors of trolling across adult and adolescent samples may play a critical role in the development of targeted interventions to prevent or manage trolling.
Dengue and chikungunya virus loads in the mosquito Aedes aegypti are determined by distinct genetic architectures
Authors: Novelo Mario , Dutra Heverton LC , Metz Hillery C. , Jones Matthew J. , Sigle Leah T. , Frentiu Francesca D. , Allen Scott L. , Chenoweth Stephen F. , McGraw Elizabeth A.
Published: April 2023

Aedes aegypti is the primary vector of the arboviruses dengue (DENV) and chikungunya (CHIKV). These viruses exhibit key differences in their vector interactions, the latter moving more quicky through the mosquito and triggering fewer standard antiviral pathways. As the global footprint of CHIKV continues to expand, we seek to better understand the mosquito’s natural response to CHIKV—both to compare it to DENV:vector coevolutionary history and to identify potential targets in the mosquito for genetic modification. We used a modified full-sibling design to estimate the contribution of mosquito genetic variation to viral loads of both DENV and CHIKV. Heritabilities were significant, but higher for DENV (40%) than CHIKV (18%). Interestingly, there was no genetic correlation between DENV and CHIKV loads between siblings. These data suggest Ae. aegypti mosquitoes respond to the two viruses using distinct genetic mechanisms. We also examined genome-wide patterns of gene expression between High and Low CHIKV families representing the phenotypic extremes of viral load. Using RNAseq, we identified only two loci that consistently differentiated High and Low families: a long non-coding RNA that has been identified in mosquito screens post-infection and a distant member of a family of Salivary Gland Specific (SGS) genes. Interestingly, the latter gene is also associated with horizontal gene transfer between mosquitoes and the endosymbiotic bacterium Wolbachia. This work is the first to link the SGS gene to a mosquito phenotype. Understanding the molecular details of how this gene contributes to viral control in mosquitoes may, therefore, also shed light on its role in Wolbachia.
Reading will not find you a husband: Eloise Bridgerton, accomplishment and the ‘thinking woman’ in the early nineteenth-century period drama
Authors: Rogers Lizzie
Published: April 2023

From the very opening scenes of Bridgerton (), Eloise Bridgerton, the second-eldest daughter, takes centre stage as a character entrenched in a Regency London world, yet immediately identifiable to a modern audience. Her desire to learn and live beyond a conventional path sets her apart in a way that provides hope to a viewing audience that desires from her a myriad of things, including the intertwining of her reticence to marry, her close friendship with Penelope Featherington and intellectual aspirations with longed-for queer representation. This article will explore how the building of Eloise’s character allows for the exploration of the gendering of intellectual freedom on-screen at a place where fact, fiction and audience desires meet. In examining the translation of the complicated nature of the ‘thinking woman’ and ‘accomplishment’ onto screen through the lens of Eloise, and the references and language used, in particular those to Wollstonecraft, as well as audience responses to and desires for Eloise, this article will demonstrate how a conflation of historical reference and modern outlook both re-energizes and often polarizes feminist tropes of the scholarly woman.
After the duke: Reflections on how Bridgerton has changed the period drama conversation
Authors: Prescott Amanda-Rae
Published: April 2023

Academics and journalists alike have written extensively on how Bridgerton () has portrayed BIPOC characters and history in the Regency era. Few writers however have attempted to analyse these questions with both academic and non-academic readers in mind. This article is a self-reflection, based analysis of how the conversation around Bridgerton has evolved over the three years since it was first released.
Absorptive capacity and the diffusion of innovation in NTBFs and startups: A study in the Brazilian Federal District
Authors: Pereira Bruno Alencar , Farias Josivania Silva
Published: April 2023

Purpose: To verify the contribution of the Absorptive Capacity (ACAP) to the diffusion of innovation in New Technology-Based Firms (NTBFs) and startups in the Brazilian Federal District. Method: In-depth interviews study with 20 innovative firms, 12 (twelve) startups and 8 (eight) NTBFs. The results are discussed in two items of analysis: Analysis of the profile of the firms and the Analysis of the Descending Hierarchical Classification (DHC) and of the content, in a comparative perspective around 14 thematic categories. Findings: The development factors associated with the Potential of Absorptive Capacity (PACAP) were observed as the antecedents of the diffusion of innovation. On the other hand, factors related to the Realized Absorptive Capacity (RACAP) are involved directly in the diffusion of innovation, with emphasis on the ability to generate innovation results through channels of market introduction, adoption of new technologies and financial investments. Theoretical/methodological contributions: The study contributes to the theoretical field, still lacking in production, especially regionally, on the relationship between the constructs investigated in the context of innovative firms. Supporting programs, can gain insights to improve the advanced support that facilitates access to knowledge to be adopted and conversion into innovation. Relevance/originality: The research extends the understanding of the relationship between ACAP and the diffusion of innovation, involving the absorption of knowledge and the dynamics of these constructs through the integration of critical factors in specific contexts still little investigated, such as in NTBFs and startups involving regional innovation ecosystems. Management/Social Contributions: The empirical investigation and factors addressed provide managerial implications for the practices of these firms when developing innovations, as well as for planning, developing or strengthening innovation programs and policies.
Interrater Reliability of Functional Lumen Imaging Probe Panometry and High-Resolution Manometry for the Assessment of Esophageal Motility Disorders
Authors: Chen Joan W. , Khan Abraham , Chokshi Reena V. , Clarke John O. , Fass Ronnie , Garza Jose M. , Gupta Milli , Gyawali C. Prakash , Jain Anand S. , Katz Philip , Konda Vani , Lazarescu Adriana , Lynch Kristle L. , Schnoll-Sussman Felice , Spechler Stuart J. , Vela Marcelo F. , Yadlapati Rena , Schauer Jacob M. , Kahrilas Peter J. , Pandolfino John E. , Carlson Dustin A.
Published: April 2023

INTRODUCTION:

High-resolution manometry (HRM) and functional lumen imaging probe (FLIP) are primary and/or complementary diagnostic tools for the evaluation of esophageal motility. We aimed to assess the interrater agreement and accuracy of HRM and FLIP interpretations.

METHODS:

Esophageal motility specialists from multiple institutions completed the interpretation of 40 consecutive HRM and 40 FLIP studies. Interrater agreement was assessed using intraclass correlation coefficient (ICC) for continuous variables and Fleiss' κ statistics for nominal variables. Accuracies of rater interpretation were assessed using the consensus of 3 experienced raters as the reference standard.

RESULTS:

Fifteen raters completed the HRM and FLIP studies. An excellent interrater agreement was seen in supine median integral relaxation pressure (ICC 0.96, 95% confidence interval 0.95–0.98), and a good agreement was seen with the assessment of esophagogastric junction (EGJ) outflow, peristalsis, and assignment of a Chicago Classification version 4.0 diagnosis using HRM (κ = 0.71, 0.75, and 0.70, respectively). An excellent interrater agreement for EGJ distensibility index and maximum diameter (0.91 [0.90–0.94], 0.92 [0.89–0.95]) was seen, and a moderate-to-good agreement was seen in the assignment of EGJ opening classification, contractile response pattern, and motility classification (κ = 0.68, 0.56, and 0.59, respectively) on FLIP. Rater accuracy for Chicago Classification version 4.0 diagnosis on HRM was 82% (95% confidence interval 78%–84%) and for motility diagnosis on FLIP Panometry was 78% (95% confidence interval 72%–81%).

DISCUSSION:

Our study demonstrates high levels of interrater agreement and accuracy in the interpretation of HRM and FLIP metrics and moderate-to-high levels for motility classification in FLIP, supporting the use of these approaches for primary or complementary evaluation of esophageal motility disorders.
Analysis of the influence of selected Slicer parameters on the mapping accuracy in the FFF method
Authors: Budzik Grzegorz , Zaborniak Małgorzata , Roczniak Jakub
Published: April 2023

The methodology and measurement results of the machine part produced directly from the 3D-CAD numerical model are presented. Representative additive techniques based on polymer processing were used. The accuracy of replication of CAD numerical models was assessed in terms of both external surface analysis and part volume.
Homo- and copolymerization of 2-benzothiazoylacrylamide with α-methyl styrene and methyl acrylate: synthesis, characterization and reactivity
Authors: Al-Mokaram Ali M.A. Abdul Amir , Hadi Mohammed Ameen , Ghani Hiba Ahmed
Published: April 2023

2-benzothiazolyl acrylamide (BTA) monomer was synthesized by reacting of 2-aminobenzothiazole with acryloyl chloride. Homo- and copolymerization of this monomer with α-methylstyrene (MSt) and methyl acrylate (MA) was carried out in dimethylsulfoxide (DMSO) solution. The prepared homo-and copolymers were characterized by Fourier Transform Infrared (FTIR) and their thermal stability was studied by thermogravimetric analysis (TGA). The composition of copolymers and the reactivity coefficients (r1, r2) were determined on the basis of sulfur analysis using linearization methods proposed by Fineman-Ross and Kelen-Tudos and the Mayo-Lewis intersection method. The derived (r1, r2) for BTA-co-MSt and BTA-co-MA are: (0.197, 0.230) and (0.294, 4.314), respectively. The microstructure of the copolymers and the distribution of the monomer sequences in the copolymers were calculated statistically, the results obtained are consistent with the values (r1, r2). BTA with MSt form alternative copolymer whilst BTA-co-MA tends to be block with MA.
​REFORMASI HUKUM KELUARGA ISLAM TUNISIA PASCA ARAB SPRING: Antara Liberalisme dan Konservatisme
Authors: Muhajir Muhammad
Published: April 2023

After the Arab Spring, which was distinguished by the development of liberalism, Tunisia's personal status law became more progressive. This liberalism is exemplified by the enactment of a law permitting Muslim women to marry non-Muslim men. Tunisia's efforts to liberalize Islamic family law appear to be impeded, however, by the rejection of a proposal to change the law on inheritance equality between men and women. The purpose of this study is to examine the liberalism of Islamic family law in Tunisia. Using information media such as news, articles, and other sources, the research utilizes a descriptive-qualitative strategy with a theoretical and fact-based approach. This article argues that there are at least three reasons for Tunisia's modest liberalization of Islamic family law 1) Avoiding confrontations with secularists as much as possible. 2) Learning from the failure of the 2014 parliamentary general election, which revealed that Tunisians prefer non-religious parties. 3) The idealistic and pragmatic reasons of Ennahdha members.Pasca terjadinya Arab Spring, sistem perpolitikan di Tunisia menjadi lebih demokratis menyebabkan liberalisme pemikiran semakin menguat. Liberalisme tersebut ditunjukan dengan disahkanya undang-undang pernikahan wanita muslimah dengan laki-laki non-muslim. Namun upaya liberalisme hukum keluarga Islam Tunisia tampaknya masih terbatas dengan ditolaknya penyeruan amandemen undang-undang persamaan hukum waris antara laki-laki dan perempuan. Penelitian artikel ini adalah penelitian pustaka (library research). Metode yang penulis gunakan adalah metode deskriptif-kualitatifdengan pendekatan teoritis dan fakta melalui media informasi baik berita, artikel, maupun sumber lainya. Hasil penelitian menyimpulkan bahwa terjadinya liberalisme terbatas hukum keluarga Islam di Tunisia disebabkan tiga alasan. 1) Menghindari ketegangan dengan kaum sekuler 2) Belajar dari pengalaman kekalahan dalam pemilihan umum legislatif pada tahun 2014 yang menujukan masyarakat Tunisia cenderung memilih partai yang tidak berbasis agama, 3) Motif idealis dan pragmatis anggota partai Ennahdha].
KONSTRUKSI AKAD NIKAH (IJAB DAN KABUL) DALAM KITĀB AL-NIKĀH KARYA MUHAMMAD ARSYAD AL-BANJARI
Authors: Norcahyono Norcahyono
Published: April 2023

Ijab and Kabul are the core elements in a marriage contract. Muhammad Arsyad Al-Banjari (17-18 AD), a Malay scholar from Banjar, wrote the ijab and kabul guidelines in the Kita>b al-Nika>h. Unlike many classical fiqh works, this book explains the guidelines for ijab and kabul clearly. This article discusses the construction of marriage contract (ijab kabul) in the book. Using a qualitative content analysis approach, this study found that the construction of ijab and kabul were written under the Banjar language with the Pegon script. The use of the local language aims to draw the broader attention of Banjar people. Description of ijab and kabul is presented with examples of marriage contracts that commonly exist in the community. This means that the construction of ijab and kabul in the book is practical—according to the needs of the Banjar people at that time. In addition to showing the practical character, Al-Banjari's fiqh on marriage contracts tends to reflect the Shafi'i School. Therefore, theoretically, it is safe to say that Al-Banjari is quite strict when it comes to following the Shafi'i school of jurisprudence.Ijab dan kabul merupakan elemen terpenting dalam akad pernikahan agar dapat dianggap sah secara hukum. Muhammad Arsyad Al-Banjari (17-18 M), seorang ulama Melayu asal Banjar, menulis tuntunan ijab dan kabul dalam Kita>b al-Nika>h. Tidak seperti kitab fikih klasik pada umumnya, kitab ini menjelaskan tuntunan ijab dan kabul secara gamblang. Artikel ini membahas kontruksi ijab dan kabul pernikahan dalam kitab tersebut. Dengan pendekatan analisis isi kualitatif, penelitian ini menemukan bahwa uraian-uraian ijab dan kabul ditulis menggunakan bahasa lokal dengan aksara Pegon. Hal ini ditujukan untuk memudahkan masyarakat Banjar memahami isi yang disampaikan. Tuntunan ijab dan kabul pernikahan juga disajikan dengan contoh akad perkawinan yang bi(a)sa terjadi dalam praktek keseharian sehingga mudah dipahami masyarakat Banjar. Artinya konstruksi ijab dan kabul dalam kitab tersebut bersifat praktis—sesuai dengan kebutuhan masyarakat Banjar pada masa itu. Selain menunjukkan karakter praktis, fikih Al-Banjari tentang akad nikah mencerminkan fikih-fikih berorientasi Mazhab Syafi’i. Oleh karena itu secara teoretis dapat dikatakan bahwa Al-Banjari cukup ketat dalam menerapkan fikih bermazhab Syafi’i.
IGNORING FAMILY LAW ADMINISTRATIVE PROCEDURE: Falsifying Death of Spouses for the Registration of New Marriage in Lengayang Muslim Community
Authors: Salma Salma , Wahida Hasanatul , Adib bin Samsudin Muhammad
Published: April 2023

The exercise of the right to register marriage and divorce frequently has to deal with the complexity of the administrative procedure. Consequently, many marriages and divorces are not registered in state institutions which lead to the next difficulty of registering new marriages for those who unregistered their divorce previously. However, a different fact happens in Lengayang, where local and state authorities collaborated to tackle administrative constraints. This paper sheds light on the shortcut taken by the Lengayang people who falsified the death of their spouses to legally register their new marriages. Data was collected through interviews and document analysis. It is then analyzed qualitatively. This article reveals that the falsification of death was utilized by Lengayang people to wittingly subdue the legal administration. This practice was backed up by the local authorities, such as ninik mamak as a customary institution, wali jorong or wali nagari as the head of the villages. The economy (the high cost), the geography (the distance of the religious court from people's domiciles), and the deadlock of social relationships between spouses foster this falsification.[Pelaksanaan pendaftaran perkawinan dan perceraian seringkali harus berhadapan dengan kompleksitas administrasi. Akibatnya, banyak perkawinan dan perceraian yang tidak dicatatkan di lembaga negara yang mengakibatkan sulitnya pencatatan perkawinan baru bagi mereka yang tidak mendaftarkan perceraiannya sebelumnya. Namun tidak bagi masyarakat Lengayang, di mana otoritas adat (lokal) dan otoritas negara bekerja sama untuk mengatasi kendala administratif tersebut. Tulisan ini menyoroti tindakan administrasi yang dilakukan oleh masyarakat Lengayang yang memalsukan kematian mantan pasangannya untuk mendaftarkan pernikahan barunya secara resmi. Pengumpulan data dilakukan melalui wawancara dan analisis dokumen. Data kemudian dianalisis secara kualitatif. Artikel ini mengungkapkan bahwa pemalsuan kematian dimanfaatkan oleh sebagian masyarakat di Lengayang untuk (secara sadar) menerobos hambatan administrasi hukum perkawinan. Praktik ini didukung oleh penguasa setempat, seperti ninik mamak sebagai kepala suku dan wali jorong atau wali nagari sebagai kepala desa. Mahalnya biaya, jauhnya jarak geografis ke Pengadilan Agama, dan mandeknya relasi (komunikasi) antara suami istri mendorong praktik pemalsuan kematian ini.
AWAKENING WOMEN'S AGENCY THROUGH ORGANIZATIONS: Legal Attitude of Muslim Women Victims of Marital Rape
Authors: Sipayung Ardhina Shafa , Sahid Mualimin Mochammad
Published: April 2023

This article sheds light on the legal attitude of Muslim women who have been victims of marital rape. The research data came from an examination of twelve court decisions in Indonesia containing cases of marital rape, completed by interviews. After conducting research, it is safe to say that the attitude of Muslim women who choose to divorce their husbands is a form of independence for these women in order to prevent various forms of sexual violence in their lives. Muslim women who take criminal action by reporting their husbands to the police argue that it has a more significant impact on the perpetrators. This latter option is inextricably linked to advocacy from women's agencies, namely the National Commission on Women, the Office of Women's Empowerment and Child Protection (DP3A), and the Integrated Service for Women and Children (P2TPA).[Artikel ini mengulas sikap hukum perempuan muslim korban pemerkosaan dalam perkawinan. Data penelitian ini diambil dari analisis dua belas putusan pengadilan di Indonesia yang berisi kasus marital rape, dilengkapi dengan wawancara. Setelah melakukan penelitian, disimpulkan bahwa para perempuan muslim korban pemerkosaan dalam perkawinan yang memilih jalur perdata dengan menggugat cerai suaminya merupakan bentuk independensi perempuan tersebut untuk menghindari diri dari berbagai bentuk kekerasan seksual. Perempuan muslim korban pemerkosaan dalam perkawinan yang memilih jalur pidana (melaporkan suaminya ke polisi) berdalih memberikan dampak yang lebih signifikan kepada pelaku. Pilihan yang terakhir ini tidak terlepas dari adanya advokasi dari agensi perempuan, yakni: Komnas Perempuan, Dinas Pemberdayaan Perempuan dan Perlindungan Anak (DP3A), dan Pusat Pelayanan Terpadu Perempuan dan Anak (P2TPA).]
THE TRANSFORMATION OF ISLAMIC ELEMENTARY SCHOOLS IN MALANG WITHIN THE TRADITIONAL ISLAMIC EDUCATION IN THE MILLENNIAL ERA
Authors: Walid Muhammad
Published: April 2023

Changes in Islamic elementary schools (as known as madrasah ibtidaiyah) are a response to the strong demands and pressures in the world of education today. The increasingly open competition encourages madrasah ibtidaiyah to change the direction of its learning and management model, which is no longer top-down, but more accommodating. This research was conducted at MIN Malang 1 and MIN 2 Druju Malang Regency. Research conducted between 2018-2019 involved many informants, including the head of the madrasa, deputy head of the madrasa, teachers, educational staff, and guardians of students. The data used as the basis for analysis are the results of observations, interviews, and documentation studies. From the data analysis, it was found that changes in madrasah ibtidaiyah occurred not only in the curriculum aspect, but also in institutional management in general. This allows madrasah ibtidaiyah to compete with other educational institutions because they have adopted an interactive-accommodative education system by juxtaposing two kinds of education; religion and general. This study confirms that the changes that occur in madrasah ibtidaiyah are not only aimed at increasing competence so that they are able to compete openly with various existing educational institutions, but also in order to show themselves as the main choice of students in obtaining knowledge that is not limited to religious knowledge. However, changes like this have the opportunity to forget the substance of the change itself, namely the presence of a new form of education that is more accommodating and responsive. Therefore, a madrasah ibtidaiyah management model is needed that is able to respond to scientific and social challenges comprehensively in the future.
El estar-siendo de los Estudios Artísticos
Authors: Gómez Moreno Pedro Pablo
Published: April 2023

Los Estudios Artísticos son un proyecto transdisciplinar que surge en el campo de las artes, sin quedar circunscrito a ellas. Su propósito general consiste en la construcción de un campo geográfica y epistémicamente localizado para la creación de conocimientos y prácticas que hagan posible comprender e intervenir en las realidades sociales, artísticas y culturales. Este espacio fronterizo de encuentro, espacio relacional y diferencial, es propicio para el diálogo y la colaboración entre las artes, las culturas, los saberes académico y no académicos, de cuyos intercambios, otros conocimientos y saberes son posibles, más allá de los saberes académicos y disciplinares.
The Effects Of Purple Grape Juice (Vitis Vinifera) On Spermatozoa Motility Of Male Wistar Rats (Rattus Norvegicus) Exposed To Electric Cigarette Smoke
Authors: Putranto Ishak Raharjo , Wibowo Dhega Anindita , Ariani RR Mahayu Dewi , Hermawati Donna
Published: April 2023

Background: Infertility in men can be caused by decreased motility of spermatozoa. Electric cigarette smoke containing nicotine can produce free radicals that cause a decrease in sperm motility. Purple grape juice which contains flavonoids can act as antioxidants that can increase the motility of spermatozoa. Objective: To prove the effect of administering purple grape juice on sperm motility of male Wistar rats exposed to electric cigarette smoke.Methods: This research is an experimental study with a post-test-only control group design. Sample consisted of 28 male Wistar rats divided randomly into 4 groups, namely negative control, positive control (given electric cigarette smoke), treatment one (given electric cigarette smoke + purple grape juice 3 mL/day), and treatment two (given electric cigarette smoke + purple grape juice 5 mL/day). The adaptation was carried out for 1 week, followed by treatment for 4 weeks, then the sperm of Wistar rats were collected and the sperm motility of Wistar rats was examined. Statistical test used Saphiro Wilk and Kruskal Wallis test.Results: Progressive motility rate of K(-), K(+), P1, P2 groups consecutively: 58.33 ± 7,52; 26,66 ± 8,16; 31,66 ± 7,52; 43,33 ± 12,11. Non progressive motility rate of K(-), K(+), P1, P2 groups consecutively: 26,66 ± 10,32; 55 ± 8,36; 43,33 ± 12,11; 35 ± 12,24. Immotility rate of K(-), K(+), P1, P2 consecutively: 18,33 ± 9,83; 28,33 ± 14,71; 20 ± 6,32; 16,66 ± 5,16. Kruskal Wallis test found a significant difference in progressive motility (p=0.002) and non-progressive motility (p=0.005).Conclusion: Purple grape juice affects sperm motility of male wistar rats exposed to electric cigarette smoke.
Case Report: Choledocholithiasis as Risk Factor for Klatskin Tumor: A Rare Cholangiocarcinoma
Authors: Setiawan L Edward Kurnia , Lestari Esa Loyallita
Published: April 2023

Background: Klatskin tumor is a rare liver cancer that involves the bile ducts. Its incidence begins to increase over time and is usually only diagnosed in patients who are already at an advanced stage. The annual incidence of klatskin tumors is not more than 1:100,000. Klatskin tumor is suspected based on signs of biliary obstruction, ultrasonography showing a stricture or bile mass, cholangiography with ERCP and MRCP, abnormal liver function tests, and elevated tumor marker CA 19-9. Case Report: A 65-year-old man presented to the hospital with complaints of yellowing of the eyes and body that began one month ago, as well as a lump in the right upper abdomen that had grown larger over the previous five months. Physical examination revealed yellow eyes, and a palpable lump in the upper quadrant of the patient's abdomen. The patient defecates looked like putty and urinates looked like tea. The diagnosis leaded to a klatskin tumor because the results of MRCP showed a mass in the hilar region of the liver that extended to the proximal common bile duct, which described the appearance of a klatskin tumor. There were an increasing CA 19-9 level and liver function tests. Conclusion: Patient has been diagnosed with klatskin tumors, has choledocholithiasis risk factor, supported by appropriate MRCP images and increasing CA 19-9 level
CORRELATION BETWEEN KNOWLEDGE AND BEHAVIOR OF USING VITAMIN C SUPPLEMENTS AMONG HEALTH AND NON-HEALTH STUDENTS IN CENTRAL JAVA DURING THE COVID-19 PANDEMIC
Authors: Jannah Isnaini Nur , Annisaa' Eva , Dini Intan Rahmania Eka
Published: April 2023

Background: During the COVID-19 pandemic, 57.1% of students used vitamin C. Everyone's behavior/actions in using vitamin C are different. This is influenced by several factors, one of which is knowledge. Objective: Knowing the differences in the level of knowledge and the different levels of behavior in using vitamin C supplements and the correlation between knowledge and behavior in using vitamin C supplements among health and non-health students in Central Java. Methods: Cross sectional analytic research using a questionnaire with purposive sampling technique. Data were analyzed using Chi-Square difference test and Rank Spearman correlation test. Results: The level of knowledge of health students related to vitamin C was in the good category (75%) and non-health students was in the sufficient category (42%). The behavior level of health students related to the use of vitamin C was in the good category (83.3%) and non-health students was in the poor category (58%). Chi-Square test showed that there were differences in the level of knowledge and behavior in using vitamin C between health students and non-health students with a p value = 0.000. There was a correlation between knowledge and the behavior of using vitamin C with a p value = 0.000. The Spearman correlation coefficient (r) obtained was 0.612. Conclusion: There were differences in the level of knowledge and different levels of behavior between health students and non-health students. There was a correlation between knowledge and behavior in using vitamin C supplements among health and non-health students in Central Java.
THE EFFECT OF KAFFIR LIME PEEL EXTRACT (Citrus hystrix) ON SPATIAL MEMORY OF MICE WITH DEMENTIA USING MORRIS WATER MAZE
Authors: Christiyanto Florentina Anindita , Mahati Endang , Wijayahadi Noor , Nindita Yora
Published: April 2023

Background: Antioxidants are a group of chemicals that protect biological systems against the potential harmful effects of oxidation processes or its reactions. Kaffir lime peel (Citrus hystrix) contains various potential antioxidants substances those are able to protect neurons from free radical-induced damage. Objective: To evaluate the effect of kaffir lime peel extract (Citrus hystrix) on the spatial memory of mice induced by Scopolamine (SCM). Methods: This research was a true experimental study with a post-test-only controlled group design. Thirty mice were randomly divided into 5 groups. SCM was injected intraperitoneally on day 1-7 and kaffir lime peel extract was given orally on day 2-7, the spatial memory testing of mice using Morris Water Maze on day 8. Data analysis used One-Way ANOVA test (α = 0.05) and continued with Post Hoc LSD test (α = 0.05). Results: The mean spatial memory of K+, K-, P1, P2,P3 were 16,33 ± 7,42; 70,00 ± 32,24; 25,66 ± 24,43; 23,00 ± 19,39; 25,00 ± 19,50 seconds respectively. There were significant differences in spatial memory in P1, P2, dan P3 to the negative control group, but there is no significant differences between treatment grups. Conclusion: Kaffir lime peel extract (Citrus hystrix) can improve the spatial memory of scopolamine-induced dementia (SCM) mice. There is no dose effect relationship between the treatment groups