bluuebunny/crossref_metadata_2025 huggingface dataset:
Nano-kirigami enabled chiral nano-cilia with enhanced circular dichroism at visible wavelengths
Authors: Liu Xing , Liang Qinghua , Zhang Xiaochen , Ji Chang-Yin , Li Jiafang
Published: January 2023

Nano-kirigami method enables rich diversity of structural geometries that significantly broaden the functionalities of optical micro/nano-devices. However, the methodologies of various nano-kirigami are still limited and as a result, the chiral nano-kirigami structure has yet been pushed to the limit for operation at visible wavelength region. Here, the merits of the various nano-kirigami strategies are comprehensively explored and bio-inspired nano-cilia metasurface with enhanced circular dichroism at visible wavelengths is demonstrated. The stereo chiral nano-cilia metasurface is designed with three-fold rotational symmetry, which exhibits tuneable chiroptical responses when the nano-cilia are deformed to form strong chiral light–matter interactions. By employing electron-beam lithography (EBL) and focused ion beam (FIB) lithography, on-chip nano-cilia metasurfaces are experimentally realized in near-infrared wavelengths region and at visible wavelengths, respectively, successfully validating the giant circular dichroism revealed in simulations. Our work is useful to broaden the existing platform of micro/nano-scale manufacturing and could provide an effective method for the realization of versatile bioinspired nanostructures with profound chiroptical responses.
A broadband, self-powered, and polarization-sensitive PdSe2 photodetector based on asymmetric van der Waals contacts
Authors: Zhang Xuran , Dai Mingjin , Deng Wenjie , Zhang Yongzhe , Wang Qi Jie
Published: January 2023

Self-powered photodetectors with broadband and polarization-sensitive photoresponse are desirable for many important applications such as wearable electronic devices and wireless communication systems. Recently, two-dimensional (2D) materials have been demonstrated as promising candidates for self-powered photodetectors owing to their advantages in light–matter interaction, transport, electronic properties, and so on. However, their performance in speed, broadband response, and multifunction is still limited. Here, we report a PdSe2 photodetector with asymmetric van der Waals (vdWs) contacts formed by using a homojunction configuration. This device achieves a high responsivity approaching 53 mA/W, a rise/decay time of about 0.72 ms/0.24 ms, and a detectivity of more than 5.17 × 1011 Jones in the visible-near infrared regime (532–1470 nm). In addition, a linear polarization-sensitive response can be observed with an anisotropy ratio of 1.11 at 532 nm and 1.62 at 1064 nm. Furthermore, a strong anisotropic response endows this photodetector with outstanding polarization imaging capabilities, realizing a contrast-enhanced degree of linear polarization imaging. Our proposed device architecture demonstrated the great potential of PdSe2-based asymmetric vdWs contacts for high-performance photodetectors operating without any external bias.
Implementation of an enhanced recovery program for complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in a referral center: a case control prospective study
Authors: Charleux-Muller Diane , Fabacher Thibaut , Romain Benoit , Meyer Nicolas , Brigand Cécile , Delhorme Jean-Baptiste
Published: January 2023

Objectives

Current recommendations regarding enhanced recovery programs (ERPs) after complete cytoreductive surgery (CCRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are based on a low level of evidence. The aim of this study is to evaluate the effect of implementing an adapted ERP for CCRS and HIPEC in a referral center.

Methods

We conducted a study with a prospective group of 44 patients (post-ERP group) who underwent CCRS with HIPEC between July 2016 and June 2018, the period during which ERP was implemented. This group was compared to a second retrospective group of 21 patients who underwent CCRS with HIPEC between June 2015 and June 2016, during which ERP was not yet implemented (pre-ERP group).

Results

The ERP compliance rate was 65% in the post-ERP group. The hospital length of stay (HLS) was shorter in the post-ERP group: 24.9 days (IQR 11–68, pre-ERP group) vs. 16.1 days (IQR 6–45, post-ERP group), as was the major morbidity rate (pre-ERP group=33.3% vs. post-ERP group=20.5%). The nasogastric tube, urinary catheter and abdominal drains were all retrieved faster in the post-ERP group.

Conclusions

The implementation of an adapted ERP after CCRS with HIPEC procedures reduces morbidity and shortens the HLS.
Development of purification of no-carrier-added 47Sc of theranostic interest: selective separation study from the natTi(n,p) process
Authors: Rizk Hoda E. , Breky Mohamed M. E. , Attallah Mohamed F.
Published: January 2023

Scandium-47 is one of the most promising medical radioisotopes, and its production and trace separation make it an attractive candidate for theranostic application. In this study, the production of no-carrier-added (NCA) 47Sc through the natTi(n,p) reaction and subsequent purification using liquid–liquid extraction was done for the theranostic application. The comparative separation of NCA 47Sc after the dissolution of an activated Ti target using Di-2-Ethylhexyl Phosphoric Acid (HDEHP) in kerosene was evaluated. The extraction process was optimized in terms of the concentration of extractant, extraction time, pH, and reaction temperature to achieve the maximum possible separation. HDEHP is efficient and promising for rapid extraction and separation of NCA 47Sc from Ti ions at low acidity (pH 0.85) with high extraction percent (>99%), contaminated with 22.3% of Ti ions after 5 min of extraction time. Different stripping reagents were used to separate loaded 47Sc and Ti ions. Firstly, 5 M HCl was enough for stripping the loaded Ti ions. Then the loaded 47Sc was separated with a purity of 100% using 0.05 M NaOH. The obtained results find the HDEHP a promising extractant for efficient separation of 47Sc from irradiated Ti target for preparing the 47Sc radiopharmaceuticals for theranostics applications.
Screening the in vitro Antimicrobial and Antioxidant Activities of Methanolic Extract of Epiphyllum oxypetalum (DC.) Haw. Leaf
Authors: Mahmad Afzan , Teh Ubaidah  , Salim Fatimah , Shaharun Maizatul Shima
Published: January 2023

Epiphyllum oxypetalum (E. oxypetalum) is traditionally used to cure liver infections, for wound healing, and to alleviate viral–related diseases. However, as the alcohol and aqueous solvents have low total phenolic and flavonoid content (TPC and TFC), antioxidant, and antibacterial capabilities, a different polarity would be more suitable. Thus, this study aimed to evaluate the methanolic extract of E. oxypetalum leaf. The chemical constituents were identified through TPC and TFC, as well as GC–MS analysis. The methanolic extract of E. oxypetalum leaf was evaluated for antimicrobial properties against five bacterial strains - Klebsiella pneumoniae, Staphylococcus aureus, Escherichia coli, Staphylococcus epidermidis, and a fungal strain of Candida albicans using the disc diffusion method. The antioxidant activity of the methanolic extract of E. oxypetalum leaf was also assessed using DPPH assay. The highest values of the TPC and TFC of the methanolic extract of E. oxypetalum leaf were  179.86 ± 0.17 mg GAE/g and 75.07 ± 0.17 mg QE/g, respectively. The GC–MS had 27 m/z peaks, indicating the presence of various bioactive compounds including phenolic compounds and fatty acids. In the antimicrobial study,  the zone of inhibition (ZOI) was between 2.8–3.5 mm for  antibacterial activity and there was also a significant antifungal activity  of 1.8 mm against Candida albicans. The IC50 DPPH assay value of methanolic extract of E. oxypetalum leaf was 14 µg/ml, indicating high antioxidant properties. This study provides evidence that the methanolic extract of E. oxypetalum leaf possesses significant antioxidant and antimicrobial properties which could be attributed to its diverse chemical constituents. These findings suggest the potential of  E. oxypetalum leaf as a natural source of  medicine, antimicrobial, and antioxidant properties.
-Based Virtual Screening Towards The Discovery of Usnic Acid Derivatives as Novel mTOR Inhibitor to Treat Breast Cancer
Authors: Wong Kelvin Khai Voon , Natasya Baharudin Nurul Farina , Roney Miah , Mohd Aluwi Mohd Fadhlizil Fasihi
Published: January 2023

In this study, mTOR is chosen as the main target for breast cancer treatment. While the existing drugs still pose severe side effects, research on finding new anti-cancer drug should be done continuously. Usnic acid (UA) has been studied for its wide range of biological properties and potential in pharmaceutical research.  A structure-based virtual screening approach is applied since it could reduce production time, cost and environmental issues. This study comprises molecular docking simulation, ADMET filtration and drug-likeness prediction. 340 UA derivatives were retrieved from literature and used to build an in-house database. The resulting compounds from docking were then filtered using ADMET prediction which comprises human intestine absorption, aqueous solubility, plasma protein binding, cytochrome P450 2D6 (CYP2D6) and hepatotoxicity parameters to identify the most potent UA derivatives with favourable physicochemical characteristics. After all, the hit compound, 118, was further stimulated in order to forecast its drug-like features. The chalcone-based scaffold of 118 resembled the reported breast cancer compound’s chemical structure strengthening the results obtained from this study. Thus, it is concluded that the structure-based virtual screening was an efficient and effective approach in the discovery of UA derivative, 118, as a potential novel mTOR inhibitor to treat breast cancer.
Aksjolingwistyczny portret wartości i ich postrzeganie przez polskojęzyczną i ukraińskojęzyczną młodzież akademicką
Authors:   Uniwersytet w Białymstoku, Borkowska Alisa
Published: January 2023

Values are an essential, intrinsic part of language and the linguistic view of the world. They are associated with the point of view and perspective of perception of the surrounding reality, and the linguistic view of the world is derived from the presumed value system. When studying language, one can discuss values, their hierarchy, the cultural orientation of the system of judgments and patterns, ways of judging, typical of a given community. Interest in the influence of values on worldview and, consequently, on intercultural communication resulted in a study in the form of an associative experiment among Polish and Ukrainian youth. Its results showed that the perception of values is most often similar or even the same in both nationality groups, e.g. associative interpretations of such phenomena as health, love, friendship, etc. Differences in understanding are more noticeable in values that are ranked differently, cf. security, honesty, etc.
Structures lexico-syntaxiques fondées sur les verbes hurler, crier, gémir dans le roman policier et dans le roman sentimental
Authors:   Uniwersytet Pedagogiczny im. Komisji Edukacji Narodowej w Krakowie, Hajok Alicja , Gabrysiak Katarzyna ,   Uniwersytet Pedagogiczny im. Komisji Edukacji Narodowej w Krakowie
Published: January 2023

The aim of our work is to describe some structures with hurler, gémir, crier in two literary genres: the detective novel and the sentimental novel. Focusing on structures with hurler, gémir, crier, we will try to show that there are privileged structures in a genre that convey additional information in specific contexts. Finally, we establish the conceptual scheme which consists of obligatory elements such as sound verb, sound element, appropriate interjection and other elements such as human names, body parts, appropriate predicate.
Teksty lingwokulturowe w nauczaniu języka polskiego jako obcego
Authors:   Uniwersytet w Białymstoku, Kuć Joanna
Published: January 2023

The implication of legends, fairy tales or stories to the teaching of foreign languages is not a new idea: the usefulness of such texts teaching Polish as a foreign language has already been emphasized in the literature of the subject. Researchers point to an important fact that manifests itself in teaching: we teach the language to adults, but we teach them as if they were children. The essential attributes of the texts in question make us refer to our personality and cultural identity, because fairy tales and legends are deeply rooted in us and co‑create an intercultural and intergenerational bridge between the past and the present. They are also the cradle of linguistic and cultural interactions with family, people of the same nationality, but also people from other cultures and languages. These texts show how much we grow into the culture of a given society and adopt traditional patterns of behavior, and hence they prove that the cycle of linguistic and cultural transmission is permanent. The cultural message takes place by introducing young generations to tradition and fundamental values of national, European and world culture.
Pirania i harpia – metafory kobiecości w felietonach Małgorzaty Domagalik
Authors:   Uniwersytet w Białymstoku, Majewska Magdalena
Published: January 2023

The aim of this paper is to examine the metaphors referring to women in Małgorzata Domagalik’s columns. The columnist shows two types of female personalities: pirania (the Piranha) and harpia (the Harpy). The author discusses how Domagalik transforms the stereotype of women using the metaphors in question. Piranhas are very insecure women who hate everything that is different, whereas harpies are extraordinary, unorthodox, and demanding a lot fromthemselves and from others. The methodological structure is based on linguistic and cultural analysis of metaphors present in Małgorzata Domagalik’s columns.
Tekstologiczno-kodykologiczne studium przypadku polskojęzycznej metryki zgonu w Liber Mortuorum (1867–1878) jako rodzaju tekstu
Authors:   Uniwersytet Jagielloński, Owsiński Piotr A.
Published: January 2023

The present paper involves a textlinguistic‑codicological analysis and attempts to identify the specific features of the Polish administrative language in the entries of the 19th c. parish register from the town of Busko‑Zdrój. The aim of the study is to answer the question as to whether the examined annotations can be regarded as a pattern of a parish register record, and henceforth as a text type. The author investigates the structure and characteristics of different register entries, with research field determined by the general structure and functionfunction of parish register records and annotations of these records.
Development of Educational Competences of Teachers in Organizations of Secondary Professional Education
Authors:   Kostroma State University, Vorontsova Anna V. , Vishnevskaya Oksana Nikolaevna ,   Kostroma State University, Skvortsova Marina A. ,   Kostroma State University, Korsakova Anastasia A. ,   Kostroma State University
Published: January 2023

Problem. The authors of the article substantiate the need for targeted work on the formation of educational competencies of college teachers. The need is determined by the change in the requirements of the state for education and the unwillingness of teachers to fulfill these requirements. The problem of the article: what are the effective ways and means of developing the educational competencies of teachers in secondary vocational education? The purpose of the article is to describe and substantiate the effectiveness of the proposed ways and means of developing the educational competencies of teachers in secondary vocational education. Methodology. The article presents a methodological description of activities for the development of educational competencies of teachers of secondary vocational education in the interaction “university-college”. The content, structure and forms of activity were designed on the basis of diagnostics of the current level of educational competencies of teachers. The assessment was carried out on the basis of the competency-based model of educational competencies according to three criteria - cognitive, motivational and practical. The identified problems and the request of the college teachers determined the topics of the seminars, as well as the choice of intensive forms of work. The quantitative-analytical design of the results of the conducted classes was based on data compared “before” and “after” (test-retest) participation in meetings, taking into account the statistical significance of the measured phenomena. To assess the effectiveness of the classes, a questionnaire and reflective reports of the participants after three meetings were used.
Existentials of the Digital age. Ideas about the Renewal of Psychological Dimensions
Authors:   Tomsk State University, Lukyanov Oleg V.
Published: January 2023

This article delves into the question on the harmony of modern psychology in the “digital” era. In light of the trends towards digitalization, we consider the problem of clarifying the systemic foundations of psychological dimensions (psychological scale). With the “digital” era the new dimensions in psychology are a form of reflection on the current imperative of transition to a new world order. We proposed a coordinate system based on the axes of complementarity of existentials of the “digitized world”: Axis of horizons (orders, “spaces”) “Digitalization for a person – a Human for digitalization” and Axis of poles (rotations, sequences, “times”) “Respect for the old – creation new.” The purpose of the study is to revise and clarify the assumptions about the future of psychology with the intentions of responding to the imperatives of the new, expected and created era that are symbolized by the metaphor of digitalization. Methodology and Research: System-anthropological psychology. Identification of correspondences, complementary relationships that correspond to the development trend and the form of presence. Based on the experience of generalizations, useful hypotheses of an orientational nature. In conclusion, the imperative for the emerging psychology is to clarify how presence and being correspond, with presence having priority. The trinity of fictitiousness, authenticity and personal responsibility is necessary to move to as a solution to the dilemma posed by just fictitiousness – authenticity. The challenge of the new world is not to choose a “good” digitalization and not to choose a “bad” one. Not “Either-Or”, but “And-And”. We should find new psychological dimensions to imitate life timely and be present in life timely. For a new reality, we need “new psychological organs” to differentiate.
RISING STARS: Hormonal regulation of the breast cancer microenvironment
Authors: Boyle Sarah Theresa
Published: January 2023

The tumor microenvironment is a dynamic ecosystem of stromal and immune cells that, under the influence of cancer cells, govern biochemical signaling, mechanical signaling via production and remodeling of the extracellular matrix (ECM), formation of vascular networks, and ultimately promotion of tumor growth. In breast cancer, hormone receptor-mediated signaling is a key coordinator of cancer cell proliferation and invasiveness not only through cell-autonomous means but also via cancer cell–stroma cross-talk. In the absence of hormone receptors, a different microenvironment landscape emerges, which comes with its own challenges for therapy. This review summarizes the current knowledge regarding the associations of hormone receptor profiles with composition of the microenvironment, how hormones directly influence stromal cells, immune cells and cells associated with the vasculature, and the paracrine mechanisms that lead to the formation of a tumor-promoting ECM.
REPRESENTACIÓN A SAN ROQUE: TEATRO BILINGÜE Y MÚSICA INCIDENTAL EN EL OURENSE DEL SIGLO XVIII
Authors: Gándara Feijóo Javier
Published: January 2023

En este artículo se estudia Representación a San Roque, una comedia hagiográfica de especial relevancia por ser uno de los pocos documentos del siglo XVIII con fragmentos en gallego. El libreto manuscrito, no examinado hasta ahora, se conserva en un archivo privado de Ourense. Siguiendo una metodología analítica, se tratarán diversos aspectos en relación con la pieza: estructura en tres actos, argumento, lenguas empleadas, caracterización de los personajes (especialmente el gallego) y música incidental. Además, se establecerán comparaciones con otras creaciones escénicas de la Edad Moderna, tanto las elaboradas en el noroeste peninsular como en diferentes latitudes. Es posible concluir que Representación a San Roque sigue la tradición teatral hispana del Siglo de Oro, pero adaptada a Galicia y a nuevas tendencias. Gracias al presente trabajo se puede afirmar que no solo eran géneros breves las obras escénicas con partes en gallego durante el XVIII en el noroeste peninsular, sino que también existieron otras de mayores dimensiones como la aquí analizada.
ARQUITETURA E ORNAMENTO NAS FESTAS DA CANONIZAÇÃO DOS JESUÍTAS ESTANISLAU KOSTKA E LUÍS GONZAGA EM PORTUGAL (1727)
Authors: Pereira Coutinho Maria João
Published: January 2023

O presente texto resulta da análise dos vários relatos referentes à dupla canonização de Luís Gonzaga (1568-1591) e Estanislau Kostka (1550-1568), em 1726, que teve particular eco no contexto nas celebrações da Companhia de Jesus em Portugal. As vertentes dos programas, da arquitetura e da cenografia contribuíram para a metamorfose dos espaços e, uma vez mais, para se afirmar a capacidade que esse instituto religioso teve para organizar celebrações e outros atos performativos, que envolveram a corte e vários segmentos sociais. Considerando os diversos testemunhos que narram estes acontecimentos, procurou-se colocar em diálogo as festas de Braga, Santarém, Lisboa e Évora, interrogando a obra e compreendendo as linhas comuns a todos estes jubileus.
SENTIDO Y SIGNIFICACIÓN DE LA DONACIÓN DE RELIQUIAS DEL CARDENAL MENDOZA AL HOSPITAL DE SANTA CRUZ DE TOLEDO
Authors: Hernández Castelló María Cristina
Published: January 2023

Analizamos en el presente artículo la donación de reliquias realizada por parte del cardenal Mendoza (1428-1495) al hospital de Santa Cruz de Toledo, a través de un documento inédito conservado en el Archivo Histórico Provincial de Toledo. Profundizamos en el valor que los vestigios sagrados alcanzaron como obsequios dentro de las prácticas sociales de la época convirtiéndose en presentes que, siendo portadores de lo sagrado, prestigiaban tanto al donante como al receptor y contribuían a la construcción de la imagen del poder.
EL CINE MEXICANO DE PISTOLEROS EN LOS AÑOS SESENTA: HERENCIAS, HIBRIDACIONES Y FÓRMULAS
Authors: Flores Silvana
Published: January 2023

Analizaremos un corpus de films mexicanos de los años sesenta en torno a historias de pistoleros, asociados al género clásico del western, pero incluyendo también rasgos del musical. Abordaremos títulos producidos por José Luis y Guillermo Calderón, promotores de una línea industrialista del cine que requería la elaboración de fórmulas de éxito para el mantenimiento del mercado nacional, ante los cambios de paradigmas estéticos en las cinematografías de la región. Los objetivos de este trabajo serán localizar las referencias que estos films tomaron de obras precedentes lanzadas en la llamada Edad de Oro del cine mexicano, así como resaltar la hibridación de estilos y narrativas presentadas en los nuevos productos, y finalmente, destacar los rasgos que sirvieron de matriz para la captación de un público popular. Tomaremos como muestra tres películas, analizando dichos textos fílmicos tanto desde los estudios sobre géneros cinematográficos como en lo referente a la configuración de personajes y espacios. Notaremos que en la crisis industrial que el cine mexicano de los sesenta atravesaba, hubo una necesidad de despuntar la rentabilidad, por medio de la actualización de géneros de éxito como las comedias rancheras, unificándolos en nuevos productos culturales estandarizados que asegurasen el retorno a las salas.
LA ARBOLEDA PERDIDA. EL BOSQUE Y EL ÁRBOL EN EL CINE VASCO y GALLEGO CONTEMPORÁNEOS
Authors: Zumalde Imanol , Castro de Paz José Luis
Published: January 2023

Este artículo se interesa por el rol temático que juega el motivo forestal en la cinematografía vasca y gallega. Para ello centra el foco en un selecto ramillete de películas contemporáneas (desde Tasio y Akelarre, ambas producciones de 1984, hasta Amama y O que arde, surgidas en los últimos años) con objeto de elucidar primero el significado que el bosque y el árbol adquieren en cada una ellas, y plantear después un estudio comparativo sobre el modo en que este selecto corpus fílmico pone al día el patrimonio simbólico que el motivo forestal acredita en el imaginario tradicional de esas latitudes.
LAS ARTES COMO FORMA DE RESISTENCIA EN TIEMPOS PANDÉMICOS
Authors: Marxen Eva
Published: January 2023

En el presente artículo mostramos cómo las artes han servido como forma de resistencia para enfrentar los efectos de la pandemia y del confinamiento. Desde 2020, la pandemia del Covid-19 ha reificado las injusticias sociales previamente existentes. Varios colectivos han organizado formas de resistencia para oponerse a las desigualdades y formas de opresión. Como ejemplo concreto se ofrece la red de la comunidad filipina en Barcelona, Cataluña/España. Esta comunidad se ha visto especialmente afectada por el Covid-19 debido a su empleo predominante en sectores de servicios, a menudo en condiciones de explotación que reflejan los legados del colonialismo. A través de una metodología etnográfica, en el marco de la antropología gramsciana y un enfoque decolonial, este trabajo analiza tanto el impacto del Covid-19 en esta comunidad como sus formas de resistencia. Se pone especial énfasis en las y los jóvenes de dicha comunidad y cómo han hecho uso de las artes para resistir los perjuicios de la pandemia. Para conseguir dicho objetivo se recurre al arte crítico, así como a varios principios de la arteterapia.
DIÁLOGOS ENTRE PANDEMIAS A TRAVÉS DEL ARTE. IMAGINARIOS DEL VIH/SIDA Y DE LA COVID-19, CUIDADOS Y AFECTOS
Authors: Martín Hernández Rut
Published: January 2023

Esta investigación presenta un estudio de las prácticas artísticas que abordan los imaginarios de las pandemias del VIH/SIDA y de la COVID-19. El objetivo principal es analizar las principales estrategias artísticas que se han implementado en relación con las representaciones sociales de la enfermedad desde la perspectiva de los cuidados y los afectos atendiendo a las conexiones y fricciones que se establecen con dichos contextos pandémicos. Se considera que, durante las primeras décadas de la pandemia de VIH/SIDA tuvieron lugar, desde el arte, tentativas emancipadoras con un importante impacto tanto en lo social como en lo artístico, y se plantea si algunas de estas estrategias han estado presentes en las prácticas artísticas sobre la COVID-19 atendiendo a la evolución y transformaciones experimentadas en el contexto actual. La metodología implementada es de carácter cualitativo, con un enfoque inductivo-interpretativo. Parte de un estudio de casos múltiple que permite determinar una serie de categorías que funcionan a modo de cartografía a partir de la cual ofrecer un análisis de las prácticas estudiadas. La investigación pone de manifiesto el potencial del arte para contrarrestar determinados ejes sobre los que se asientan los imaginarios de las enfermedades infecciosas pandémicas en la contemporaneidad y para constituirse como una herramienta de acción en el seno de lo social, en colaboración con otras disciplinas.
VIAJE AL FIN DE LA NOCHE. VISIONES DE LO MONSTRUOSO
Authors: Ruiz de Samaniego Alberto
Published: January 2023

Si la pandemia ha sido monstruosa y nos ha obligado a replantearnos nuestra existencia, no solo es porque lo monstruoso se defina como lo que aparece sin haberse previsto, sino porque el modo de existencia de la humanidad ha tenido que ver, desde siempre, con la amenaza de extinción y con la frontera de una vida que se proyecta en el límite. A ese límite de lo real suele apelar tanto el mito como la representación artística, pero tampoco conviene confundir la actual inflación de representaciones con semejante proyección.
ENFERMOS DE PECADO. EL CUIDADO TEOLÓGICO EN LOS HOSPITALES MEDIEVALES
Authors: Moral de Calatrava Paloma
Published: January 2023

A finales del siglo XV Jehan Henry escribió su Livre de vie active de l’Hôtel Dieu de Paris y se lo dedicó a las monjas-enfermeras que atendían el hospital. Los historiadores de la Enfermería suelen afirmar que una miniatura de este manuscrito ilustra cómo cuidaron las enfermeras a sus pacientes, pero este trabajo cuestiona el significado médico de esta imagen y la naturaleza feminizada de la enfermería medieval. El análisis de las relaciones teóricas y prácticas entre teología y medicina, y el de las reglas de las órdenes monásticas demuestran que enfermeros y enfermeras no prestaron atención sanitaria. En este trabajo pruebo que los enfermeros de los hospitales medievales encarnaban al Buen Samaritano y emplearon el cuidado al cuerpo como una excusa para ocuparse del alma de los pacientes.
ANTONIO PALACIOS Y EL PROYECTO PARA LA NUEVA RÚA GALICIA EN SANTIAGO DE COMPOSTELA (1932). IMAGINAR UNA CIUDAD HISTÓRICA VIVA Y ARMÓNICA EN EL CONTEXTO DEL REGIONALISMO
Authors: Sánchez García Jesús Angel
Published: January 2023

Reproducción y análisis del proyecto de Rúa Galicia para Santiago de Compostela preparado en 1932 por Antonio Palacios con la intención de construir una extensión de la ciudad histórica que solucionara el acceso de vehículos hasta la plaza del Obradoiro. El proyecto buscó la armonización e integración con las arquitecturas y trazados dominantes en el conjunto histórico, vinculándose con la cultura urbanística conservacionista, el regionalismo y las intervenciones de restauración sobre las ciudades históricas europeas en las primeras décadas del siglo XX.
Aprendizaje del mundo y sociabilidad cortesana en las Cartas de Lord Chesterfield a su hijo
Authors: Laspalas Pérez Javier
Published: January 2023

Las cartas que escribió Lord Chesterfield para su hijo natural, Philip Standhope, con la intención de ayudarle a convertirse en un destacado político, son justamente famosas, pero su contenido no se ha estudiado aún con suficiente atención y profundidad. Además, los historiadores apenas se han interesado por ellas, a pesar de que revelan aspectos muy relevantes de la formación y la mentalidad aristocrática. En este artículo reconstruimos la imagen de la vida cortesana que se dibuja en ellas, similar a la que habían trazado antes Gracián, La Rochefoucauld y La Bruyère. Sin embargo, el discurso es más explícito y las cuestiones se plantean con un sincero y crudo realismo.
El Escorial de abajo: una villa a la sombra del Real Monasterio después de la Guerra de la Independencia
Authors: Bringas Gutiérrez Miguel Ángel , Camarero Bullón Concepción
Published: January 2023

En este artículo abordamos algunas cuestiones generales sobre la historia de la villa de El Escorial a partir del análisis de dos fuentes históricas elaboradas entre 1818 y 1824: el cuaderno general de la riqueza de 1818-1820 y el padrón general del vecindario de 1824. El primero es una estadística de la riqueza y de la producción cuyo origen está en relación con el intento de realizar una profunda reforma de la hacienda impulsada por Martín de Garay durante el reinado de Fernando VII. Con esta documentación se analizan por primera vez las bases que sustentaban la economía de El Escorial pocos años después de finalizada la Guerra de la Independencia. Se constata el decisivo peso que la explotación de los montes y la ganadería tenían en la economía local. Y, el segundo, recoge de forma detallada las principales características de la población escurialense (sexo, edad, profesión, número de familias, etc.) entre ellas, la importancia que tuvo el componente inmigratorio a la hora de explicar la configuración de su estructura demográfica.
Does a graft located in the canopy of a rubber tree affect the morphologies of cells in the adjacent wood?
Authors: dos Santos Glaycianne Christine Vieira , Latorraca João Vicente de Figueiredo , Toniasso Lívia Fernanda Lavrador , Ramos Letícia Maria Alves , Pace José Henrique Camargo , de Almeida Sabrina Mayer , Neto Thayanne Caroline Castor
Published: January 2023

The objective of this study was to characterize the wood anatomical structure of a rubber tree clone, under the influence of two different canopy grafts. The following rubber trees were selected in the system of a double-grafted PB 311 + FX 2784 and PB 311 + MDF 180. For each tree, discs of wood were cut from the affected branch immediately below the insertion of clone at right angles to the axis, from which the regions corresponding to tension, in opposite and normal wood, were identified. The anatomical analyses were conducted in accordance with the standards established by the International Association of Wood Anatomy Committee. The Kruskal-Wallis nonparametric test was applied for multiple comparisons among the types of woods and radial positions studied, at 5% of significance. Still, multivariate associations were assessed among the anatomical characteristics of both double-grafted rubber trees, by means of a two-step cluster analysis. Quantitative morphological differences were observed in the wood cells of the double-grafted studied clones. The ray height and the vessels diameter were the most important morphologic characteristics for the distinction. The canopy clone exhibited the ability to modulate the quantitative anatomical characters of the panel clone, depending on the plant’s needs.
Drug repurposing: Recent advancements, challenges, and future therapeutics for cancer treatment
Authors: Entonu Moses Edache , IKA Mbateudi Danjuma , Emmanuel Ekpa , Barnabas Clifford Liki , Gaiya Daniel Danladi , UDU Stella Kuyet
Published: January 2023

Cancer is a prime public health burden that accounts for approximately 9.9 million deaths worldwide. Despite recent advances in treatment regimen and huge capital investment in the pharmaceutical sector, there has been little success in improving the chances of survival of cancer patients. Drug repurposing sometimes termed drug repositioning is a strategy of discovery and redeveloping existing drugs for new therapeutic purposes. This novel approach is highly efficient, considerably cuts research and development costs, reduces the drug development timeline, maximizes therapeutic value and consequently increases success rate with minimum risk of failure. In this review, prioritizing drug repurposing to activate immune and inflammatory responses to target tumor cells through immune surveillance mechanism is a promising strategy for cancer immunotherapy. Cancer immunotherapy cover myriad of therapeutic approaches as cytokine therapy, immune checkpoint blockade therapy, cancer vaccines, natural killer cells, adoptive T cell therapies, monoclonal antibodies, oncolytic viruses, computational approach and host of others. In the current pipeline, drug repurposing is devoid of adequate funding and the necessary legal support for research and development by stakeholders. At the moment, immunotherapy strategies combine with computational biology could be considered the new milestone in drug re-profiling for cancer treatment.
Die Wiener Weltausstellung 1873. •
Authors: Ujvári Hedvig
Published: January 2023

The oeuvre of the orientalist, Turkologist and traveler Ármin Vámbéry has been well researched, his long life full of adventures and his travels made him a famous personality on several continents during the Dualism-era, and so he has not succumbed to oblivion to this day. However, his creativity and work are multi-layered, so they require the approaches of various scientific disciplines, e.g. some facets of his widely ramified and not least unexplored journalistic work can be contributed to Vámbéry research. This article is devoted to Vámbéry's publication on the occasion of the Vienna World Exhibition of 1873, which also allow a comparison with the feuilletons of his friend, who later became a writer, cultural critic and Zionist, Max Nordau (1849, Pest–1923, Paris).
Nurtured and sorrowful: Positive and negative emotional appeals in early COVID-19 themed brand communications
Authors: Mensa Marta , Vargas-Bianchi Lizardo
Published: January 2023

This study examines the prevalence of emotional appeals in COVID-19-themed brand advertisements from around the world in the months immediately following the World Health Organization’s declaration of the coronavirus outbreak as a pandemic. The study analyses the frequencies of use of positive and negative emotional appeals in the content of the ads, and concurrent combinations of such appeals. A content analysis was conducted on a sample of 376 ads from the “Ads of The World” digital archive. The results reveal a preference for positive emotions, with nurturance and affiliation being the most frequent. Sorrow was the third most preferred emotional appeal, and the most used negative emotion. Some brands have compared the virus to a hurricane (Brazil), an assassin with a chainsaw (US) or the death personified (Peru). Advertisers should be careful when using negative emotional appeal content during COVID-19. According to the law of apparent reality, during times of stress the recommendation is to be cautious with negative emotions, as they may be felt more intensely by consumers. Advertising has a social responsibility, which can be directed at promoting consumer behaviours that leave a positive or negative impact on their communities. In a situation such as the pandemic, brand communication professionals must use emotions rigorously, employing this resource to contribute to society, avoiding giving rise to harmful attitudes or behaviours. The research findings are consistent with the literature and lead to future examination of emotional appeals in advertising in stressful and uncertain circumstances.
Regional public subsidies for the media in Spain: amounts, beneficiaries and impact on income statements
Authors: Aguado-Guadalupe Guadalupe , Blasco-Gil José-Joaquín
Published: January 2023

This article analyses public subsidies for the media awarded by Spain’s autonomous communities in the years 2018, 2019 and 2020. The aim is to establish the amounts and the number of beneficiaries, as well as what such subsidies represent as a proportion of the main beneficiaries’ operating incomes. To that end, 38 calls for applications for subsidies issued by nine autonomous communities were analysed, as were their respective decisions. The total amounts, the itemised subsidies received by each media outlet, and the three main beneficiaries per call have been identified. For the main beneficiaries, the subsidies as a proportion of their operating incomes have been calculated. It is concluded that the press sector received the largest volume of subsidies but is not very financially dependent on them. However, many examples of private radio and television outlets whose activities are maintained by public funding were observed. In the audiovisual sector, it was found that public subsidies represented more than 20% of some beneficiary’s total declared income, and even up to 50% in some cases.
Programmable living nanorobots
Authors: ZİDAN Ammar , AŞIR Süleyman
Published: January 2023

There are many different nanorobots in the literature, but the nanorobots that we will talk about in this review is a unique robot and the first of its kind because it is made entirely from the heart and skin cells of a frog, which means only living cells without any artificial materials. This type of robot has been programmed and studied using the silico system, in which the heart and skin cells will be arranged before being applied in vivo have been designed. On the other hand, this robot has many negatives, like anything in our world has disadvantages and advantages, so we will mention them and discuss them in this review by mentioning the aspirations and future directions of this unique robot.
Legal Regulation of Regional Industry Specialization as a Factor of Economic Development Hindering
Authors:   Institute of Social and Economic Research, Dagestan Federal Research Center of the Russian Academy of Sciences, Sagidov Yury
Published: January 2023

In the article sectoral specialization of regions in the perspective of long-term social and economic development: analysis of the state and justification of new approaches to the formation of the structure of the economy are presented. The basis of the study is fundamental papers of domestic and foreign scientists, materials of legal support for the development and practical implementation of strategic plans for the social and economic development of the constituent entities of the Russian Federation. The article argues the assertion that industry specialization does not lead to sustainable development of regions under any circumstances, and determines the conditions under which the desirable effect can be achieved. The analysis and evaluation of the existing legal support of spatial organization of the country in the processes of development and implementation of long-term programs of social and economic development are carried out. It was proved that that the existing legal attitudes do not contribute to one of the main functions of public administration, i.e. revival of the social environment with healthy market relations. The economic focus of the regions is achieved by non-market imperative methods of regulation of the narrowed composition of specialization branches, which is due to a deformed idea of fundamentals of the economic orientation of the regions. Negatives are identified, due to the imperfection of the legal framework of industry specialization, among which the determinants of many causal negative factors are as follows: a gap in the mutually conditioning relationship between economic and social development, hindering of development of relatively economically prosperous regions, permanent conservation of increasing backwardness of the regions of economically peripheral Russia, aggravation of the problem of unemployment in labor-surplus regions. The list of causal negative factors and threats to social stability at regional and national levels is given, and measures to prevent them are identified. Measures of revision and improvement of the entire system of legal acts according to the criteria for ensuring sustainable interrelated social and economic development are proposed.
Energy Efficiency Analysis of SME Sector at Macro and Meso Levels: Problem and Solutions
Authors:   Volgograd State University, Bogachkova Lyudmila , Rodionov Yury ,   Volgograd State University
Published: January 2023

Russia joined the global Agenda for Sustainable Development, what implies a doubling of energy efficiency of the economy by 2030, what is ensured by special measures of state policy and monitoring of its effectiveness. Energy efficiency improvement in the field of SMEs is essential both to reduce the energy intensity of the entire economy and to improve the competitiveness of small and medium-sized enterprises. At the same time, the Russian system of accounting and analysis of energy efficiency is not sufficiently developed. Currently, Rosstat does not produce data on the consumption of the SME sector and does not calculate energy intensity either for the SME sector as a whole, or by types of activity or by territories. The development of energy efficiency analysis tools of SMEs is an urgent scientific and practical problem. The article suggests a method for the analysis of relevant Rosstat data which allows to identify the most important areas for energy efficiency improvement in the SME sector by territories and types of activity. The authors identified federal districts and regions that are leaders in the contribution of the SME sector to the gross regional product and, at the same time, outsiders in terms of the rate of reduction in the energy intensity of the economy. These regions are expected to give special attention to strengthening measures which improve the energy efficiency of SMEs. The authors identified the types of activities in which the strengthening of energy efficiency policies is of paramount importance due to the largest weight in the turnover structure of SMEs and due to the significantly higher energy intensity of production than the average for the economy. The authors suggest studying the possibility of introducing an energy management level index to improve the tools for energy intensity analysis of the SME sector.
Research of Youth Migration Preferences in an Old Industrial Region (By the Example of Volgograd Region)
Authors:   Volgograd State Technical University, Akimova Olga , Volkov Sergey ,   Volgograd State Technical University, Bobrikova Anna ,   Volgograd State Technical University, Kalmykova Irina ,   Volgograd State Technical University
Published: January 2023

Currently, most of old industrial regions in Russia are faced with the problem of the outflow of the working population, including young people. The outflow of human capital threatens not only with a long-term economic decline in economic development, but also with an increase in social tension within the “shrinking” old industrial region. The problem of the outflow of the working population and shrinkage of the working space is also typical of Volgograd region. The main purpose of this study is to analyze the migration preferences of young people (generation of centennials) in the Volgograd region, to identify stimulating and restraining factors for the migration from the region. The article attempts to prove, on the basis of statistical data that the Volgograd region is an old industrial region and analyze, based on a survey of young people how it shrinks due to their migration. Empirical data were obtained in the course of a survey of young people from 17 to 27 years old in Volgograd region. The survey was conducted in the form of an online questionnaire on the Google Forms from March 14th to April 2nd 2022. The study involved 976 students from 8 educational institutions of Volgograd. Comparison of the results obtained with the statistical data analyzed by the authors of the article made it possible to record the reluctance of young people to stay in Volgograd region due to economic factors and development problems. The key reasons for unwillingness to stay in Volgograd region are: low wages, problems with employment and lack of career growth. There is a huge lag in the needs of young people in terms of wages and real opportunities of employers due to the slowdown in economic growth in Volgograd region, which is forcing young people to leave for more developed regions of the country. Employers in the region cannot offer high wages to young workers, and young people are not ready to work under such conditions. The only factor that keeps the majority from moving is the presence of relatives and friends whom young people cannot leave. If new jobs were created in the region, the level of well-being of citizens increased, social infrastructure developed, and then the loss of the young population of the city could be stopped. The results of this study can be useful to officials responsible for regional development at both the regional and federal levels.