bluuebunny/crossref_metadata_2025 huggingface dataset:
Optical Performance of a Segmented Extended-Depth-of-Focus Intraocular Lens under the Influence of Different Values of Spherical Aberration Generated by Refractive Surgery
Authors: Salvá Luís , García Scott , García-Delpech Salvador , Martínez-Espert Anabel , Ferrando Vicente
Published: July 2023

Background: Corneal refractive surgery induces high-order aberrations, specifically spherical aberration (SA). These aberrations can have implications when patients later develop cataracts and require the implantation of multifocal intraocular lenses (MIOLs). MIOLs with asymmetric designs pose challenges in predicting outcomes, particularly in these cases. The aim of this study was to evaluate how different values of SA, resulting from various types of refractive surgeries, affect the optical performance of the FEMTIS Comfort intraocular lens. Methods: The through-focus modulation transfer function (TF-MTF) curve and high-contrast images of tumbling E were used as parameters to assess the optical performance of the MIOL. These parameters were measured using an adaptive optics visual simulator. Results: Increasingly negative values of SA make the MIOL more bifocal, moderating its extended-depth-of-focus characteristic. Conversely, higher positive SA values cause the TF-MTF curve to shift towards positive vergences, leading to worsened distance vision in the +1.00 to +2.00 D range, but improved vision in the +0.50 D to +1.00 D range. Conclusions: Assessing SA in patients prior to implanting MIOLs with asymmetric designs is necessary for predicting outcomes and making informed decisions based on the visual requirements of patients.
Minimum 5-Year Follow-Up Assessment of Volar Plate Interposition Arthroplasty for Post-Traumatic Osteoarthritis in Proximal Interphalangeal Joints
Authors: Chang Chung-Chia , Lin Sung-Yen , Lu Chun-Kuan , Jupiter Jesse B. , Fu Yin-Chih , Liu Wen-Chih
Published: July 2023

This is a retrospective study to evaluate the outcome of volar plate interposition arthroplasty for proximal interphalangeal joint post-traumatic osteoarthritis with a minimum 5-year follow-up. We identified patients receiving volar plate interposition arthroplasty for post-traumatic osteoarthritis in proximal interphalangeal joints. The measurements included the numeric pain scale (on a scale of 0–10), the proximal interphalangeal joint active range of motion, the Michigan Hand Outcomes Questionnaire, the perioperative radiograph of the involved digit, proximal interphalangeal joint stability, and pinch strength. Eight patients with a median age of 44 years old (interquartile range (IQR): 29.3–56.8) were included in this study. The median follow-up period was 6.5 years (range of 5–11 years). The median numeric pain scale improved from 5 (IQR: 4.3–6.0) preoperatively to 0 (IQR 0–0.8) at the follow-up evaluation (p = 0.011). All digits demonstrated stability during manual stress testing compared to their noninjured counterparts. The median active proximal interphalangeal joint arc of motion improved from 25° to 55° (p = 0.011). The pinch strength of the fingers on the injured hand was weaker than those on the contralateral hand (2.2 Kg vs. 3.7 Kg, p = 0.012). We suggested that volar plate interposition arthroplasty may be an alternative surgical option for post-traumatic osteoarthritis in the proximal interphalangeal joints.
Microleakage of Restorative Materials Used for Temporization of Endodontic Access Cavities
Authors: Wuersching Sabina Noreen , Moser Luise , Obermeier Katharina Theresa , Kollmuss Maximilian
Published: July 2023

A tight temporary seal applied to an access cavity is thought to improve endodontic outcomes. This study aims to assess the bacterial and glucose microleakage of different types and combinations of temporary restorations. Human-extracted incisors were instrumented, dressed with a calcium hydroxide paste, and sealed with Cavit W (CW), CW/Ketac Molar (CW/KM), CW/Smart Dentin Replacement (CW/SDR), Intermediate restorative material/KM (IRM/KM), or Clip F (CF). Standardized 3D-printed hollow test specimens were manufactured and temporized in the same manner. The specimens were examined for bacterial and glucose leakage for 28 days. Data were analyzed using a Kaplan–Meier survival analysis. CW/SDR and CF showed the least bacterial and glucose leakage over time. CW, CW/KM, and IRM/KM had similarly high levels of glucose leakage, but CW/KM and IRM/KM provided a tighter seal against bacterial penetration than CW. CW/SDR and CF should be considered for the sealing of access cavities of teeth previously restored with methacrylate-based materials.
Sliding Mode Control with Feedforward Compensation for a Soft Manipulator That Considers Environment Contact Constraints
Authors: Chen Yinglong , Sun Qiang , Wang Jia , Zhang Junhao , Zhao Pengyu , Gong Yongjun
Published: July 2023

Soft manipulators have desirable environmental compatibility because of their pliability. However, this pliability also brings challenges to modeling and control when considering contact or collision with the environment. In previous work, we established several mathematical models for describing fluidic soft manipulators under environmental effects and verified their accuracy. However, the controller design for a soft manipulator is still a significant challenge, especially under the conditions of environmental contact. In this paper, we build upon our previously established work by conducting feedforward compensation for a soft manipulator under contact constraints and designing a sliding mode controller based on an operational space dynamics model. Then, we combine the feedforward compensation model with the sliding mode controller to realize accurate position control of the soft manipulator. Finally, simulation and experimental results show that this controller can accurately and effectively control the position of the soft manipulator.
Cannabis- and Substance-Related Carcinogenesis in Europe: A Lagged Causal Inferential Panel Regression Study
Authors: Reece Albert Stuart , Bennett Kellie , Hulse Gary Kenneth
Published: July 2023

Recent European data facilitate an epidemiological investigation of the controversial cannabis–cancer relationship. Of particular concern were prior findings associating high-dose cannabis use with reproductive problems and potential genetic impacts. Cancer incidence data age-standardised to the world population was obtained from the European Cancer Information System 2000–2020 and many European national cancer registries. Drug use data were obtained from the European Monitoring Centre for Drugs and Drug Addiction. Alcohol and tobacco consumption was sourced from the WHO. Median household income was taken from the World bank. Cancer rates in high-cannabis-use countries were significantly higher than elsewhere (β-estimate = 0.4165, p = 3.54 × 10−115). Eighteen of forty-one cancers (42,675 individual rates) were significantly associated with cannabis exposure at bivariate analysis. Twenty-five cancers were linked in inverse-probability-weighted multivariate models. Temporal lagging in panel models intensified these effects. In multivariable models, cannabis was a more powerful correlate of cancer incidence than tobacco or alcohol. Reproductive toxicity was evidenced by the involvement of testis, ovary, prostate and breast cancers and because some of the myeloid and lymphoid leukaemias implicated occur in childhood, indicating inherited intergenerational genotoxicity. Cannabis is a more important carcinogen than tobacco and alcohol and fulfills epidemiological qualitative and quantitative criteria for causality for 25/41 cancers. Reproductive and transgenerational effects are prominent. These findings confirm the clinical and epidemiological salience of cannabis as a major multigenerational community carcinogen.
Next-Generation-Sequencing-Based Simple Sequence Repeat (SSR) Marker Development and Linkage Mapping in Lentil (Lens culinaris L.)
Authors: Topu Mustafa , Sesiz Uğur , Bektaş Harun , Toklu Faruk , Özkan Hakan
Published: July 2023

Simple sequence repeats (SSRs) are highly versatile markers in genetic diversity analysis and plant breeding, making them widely applicable. They hold potential in lentil (Lens culinaris) breeding for genetic diversity analysis, marker-assisted selection (MAS), and linkage mapping. However, the availability and diversity of SSR markers in lentil is limited. We used next-generation sequencing (NGS) technology to develop SSR markers in lentil. NGS allowed us to identify regions of the lentil genome that contained SSRs. Illumina Hiseq-2000 sequencing of the lentil genotype “Karacadağ” resulted in 1,727,734 sequence reads comprising more than 48,390 Mb, and contigs were mined for SSRs, resulting in the identification of a total of 8697 SSR motifs. Among these, dinucleotide repeats were the most abundant (53.38%), followed by trinucleotides (30.38%), hexanucleotides (6.96%), tetranucleotides (6.59%), and pentanucleotides (3.19%). The most frequent repeat in dinucleotides was the TC (21.80%), followed by the GA (17.60%). A total of 2000 primer pairs were designed from these motifs, and 458 SSR markers were validated following their amplified PCR products. A linkage map was constructed using these new SSRs with high linkage disequilibrium (209) and previously known SSRs (11). The highest number of SSR markers (43) was obtained in LG2, while the lowest number of SSR markers (19) was obtained in LG7. The longest linkage group (LG) was LG2 (86.84 cM), whereas the shortest linkage group was LG7 (53.46 cM). The average length between markers ranged from 1.86 cM in LG1 to 2.81 cM in LG7, and the map density was 2.16 cM. The developed SSRs and created linkage map may provide useful information and offer a new library for genetic diversity analyses, linkage mapping studies, and lentil breeding programs.
Risk Factors and Outcomes of Children with Congenital Heart Disease on Extracorporeal Membrane Oxygenation—A Ten-Year Single-Center Report
Authors: Amodeo Antonio , Stojanovic Milena , Erdil Tugba , Dave Hitendu , Cesnjevar Robert , Paal Sebastian , Kretschmar Oliver , Schweiger Martin
Published: July 2023

For children born with congenital heart defects (CHDs), extracorporeal life support may be necessary. This retrospective single-center study aimed to investigate the outcomes of children with CHDs on extracorporeal membrane oxygenation (ECMO), focusing on various risk factors. Among the 88 patients, 36 (41%) had a single-ventricle heart defect, while 52 (59%) had a biventricular defect. In total, 25 (28%) survived, with 7 (8%) in the first group and 18 (20%) in the latter. A p-value of 0.19 indicated no significant difference in survival rates. Children with biventricular hearts had shorter ECMO durations but longer stays in the intensive care unit. The overall rate of complications on ECMO was higher in children with a single ventricle (odds ratio [OR] 1.57, 95% confidence interval [CI] 0.67–3.7); bleeding was the most common complication in both groups. The occurrence of a second ECMO run was more frequent in patients with a single ventricle (22% vs. 9.6%). ECMO can be effective for children with congenital heart defects, including single-ventricle patients. Bleeding remains a serious complication associated with worse outcomes. Patients requiring a second ECMO run within 30 days have lower survival rates.
Effects of Abrasive Waterjet Machining on the Quality of the Surface Generated on a Carbon Fibre Reinforced Polymer Composite
Authors: Rowe Andrew , Pramanik Alokesh , Basak Animesh Kumar , Prakash Chander , Subramaniam Shankar , Dixit Amit Rai , Radhika N.
Published: July 2023

The effect of the water pressure, traverse speed, and abrasive feed rate on the circularity, cylindricity, kerf taper, and surface roughness of holes produced by abrasive waterjet machining (AWJM) of a carbon-fibre-reinforced polymer (CFRP) composite was investigated in the current study. It was found that the circularity deviation decreased as the water pressure was increased. Cylindricity was affected by all three parameters, although the abrasive feed rate caused the largest deviations as it increased. The surface roughness was affected by all three, but a clear connection was not able to be concluded. The kerf taper ratio reduced with an increase in water pressure, while it increased with an increase in the abrasive feed rate and an increase in the traverse speed. To obtain optimum results, the water pressure should be increased, the traverse speed should be decreased, and the abrasive feed rate can remain constant but is recommended to be slightly reduced.
Sequencing the Genomes of the First Terrestrial Fungal Lineages: What Have We Learned?
Authors: Gryganskyi Andrii P. , Golan Jacob , Muszewska Anna , Idnurm Alexander , Dolatabadi Somayeh , Mondo Stephen J. , Kutovenko Vira B. , Kutovenko Volodymyr O. , Gajdeczka Michael T. , Anishchenko Iryna M. , Pawlowska Julia , Tran Ngoc Vinh , Ebersberger Ingo , Voigt Kerstin , Wang Yan , Chang Ying , Pawlowska Teresa E. , Heitman Joseph , Vilgalys Rytas , Bonito Gregory , Benny Gerald L. , Smith Matthew E. , Reynolds Nicole , James Timothy Y. , Grigoriev Igor V. , Spatafora Joseph W. , Stajich Jason E.
Published: July 2023

The first genome sequenced of a eukaryotic organism was for Saccharomyces cerevisiae, as reported in 1996, but it was more than 10 years before any of the zygomycete fungi, which are the early-diverging terrestrial fungi currently placed in the phyla Mucoromycota and Zoopagomycota, were sequenced. The genome for Rhizopus delemar was completed in 2008; currently, more than 1000 zygomycete genomes have been sequenced. Genomic data from these early-diverging terrestrial fungi revealed deep phylogenetic separation of the two major clades—primarily plant—associated saprotrophic and mycorrhizal Mucoromycota versus the primarily mycoparasitic or animal-associated parasites and commensals in the Zoopagomycota. Genomic studies provide many valuable insights into how these fungi evolved in response to the challenges of living on land, including adaptations to sensing light and gravity, development of hyphal growth, and co-existence with the first terrestrial plants. Genome sequence data have facilitated studies of genome architecture, including a history of genome duplications and horizontal gene transfer events, distribution and organization of mating type loci, rDNA genes and transposable elements, methylation processes, and genes useful for various industrial applications. Pathogenicity genes and specialized secondary metabolites have also been detected in soil saprobes and pathogenic fungi. Novel endosymbiotic bacteria and viruses have been discovered during several zygomycete genome projects. Overall, genomic information has helped to resolve a plethora of research questions, from the placement of zygomycetes on the evolutionary tree of life and in natural ecosystems, to the applied biotechnological and medical questions.
MALDI-TOF MS: A Quick Method to Detect the Susceptibility of Fusarium spp. Clinical Isolates to Amphotericin B
Authors: Grizante Barião Patrícia Helena , Cayún Yasna , Sepúlveda Marcela , Tonani Ludmilla , Gonçalves de Almeida Otavio Guilherme , Cornejo Pablo , Dias Nathalia , Santos Cledir , von Zeska Kress Marcia Regina
Published: July 2023

Disseminated fusariosis is treated with amphotericin B and voriconazole. To determine adequate therapy, the minimal inhibitory concentration (MIC) is used. However, MIC analysis is based on visual observation and requires a long period of fungal incubation. The measure of the minimal profile change concentration (MPCC) using MALDI-TOF MS is a quick spectral method that has presented good results in determining the antimicrobial resistance of yeasts. However, there is a lack of information on filamentous fungi. In the present work, 13 Fusarium spp. clinical isolates and two reference strains were used. MIC was obtained according to the M38-A2 protocol of the Clinical Laboratory Standards Institute, while MPPC was obtained following the initial steps of the M38-A2 protocol. Both Biotyper and the Rstudio environment were used to analyze mass spectra. For some fungal strains, the data obtained from the software MALDI Biotyper Compass 4.1 led to fuzzy heatmaps resulting in difficult interpretation, while heatmaps obtained using Rstudio tools generated better MPCC resolutions. Herein, 86.6% of the AMB MPCC values were highly correlated with the gold-standard AMB MIC. MALDI-TOF MS is a prominent tool used to determine MPCCs quicker, cost-effectively, and more accurately for Fusarium spp. strains. However, better statistical analyses could help measure the technique’s limit detection.
Viability and Desiccation Resistance of Bartonella henselae in Biological and Non-Biological Fluids: Evidence for Pathogen Environmental Stability
Authors: Bush Janice C. , Maggi Ricardo G. , Breitschwerdt Edward B.
Published: July 2023

Pathogen environmental stability is an often-neglected research priority for pathogens that are known to be vector-transmitted. Bartonella henselae, the etiologic agent of Cat Scratch Disease, has become a “pathogen of interest” in several serious human illnesses, which include neoplastic, cardiovascular, neurocognitive, and rheumatologic conditions. Survival in the flea gut and feces as well as the association with a biofilm in culture-negative endocarditis provides insight into this organism’s ability to adjust to environmental extremes. The detection of B. henselae DNA in blood and tissues from marine mammals also raises questions about environmental stability and modes of pathogen transmission. We investigated the ability of B. henselae to survive in fluid matrices chosen to mimic potential environmental sources of infective materials. Feline whole blood, serum and urine, bovine milk, and physiologic saline inoculated with a laboratory strain of B. henselae San Antonio 2 were subsequently evaluated by culture and qPCR at specified time intervals. Bacterial viability was also assessed following desiccation and reconstitution of each inoculated fluid matrix. Bartonella henselae SA2 was cultured from feline urine up to 24 hours after inoculation, and from blood, serum, cow’s milk, and physiologic saline for up to 7 days after inoculation. Of potential medical importance, bacteria were cultured following air-desiccation of all fluid inoculates. The viability and stability of Bartonella within biological and non-biological fluids in the environment may represent a previously unrecognized source of infection for animals and human beings.
Fatty Acid and Phenolic Profiles of Virgin Olive Oils from Local and European Varieties Planted in Lebanon
Authors: El Riachy Milad , Moubarak Peter , Al Hawi Ghenwa , Geha Myriam , Mushantaf Walid , Estephan Nathalie , Skaff Wadih
Published: July 2023

In Lebanon, olive oil is an integral part of its history and culinary traditions. However, the quality of this product, originating from different growing regions of the country, is rarely addressed. The objectives of this study were to compare the fatty acids and phenolic profiles of virgin olive oils produced from two local and eight European varieties, and to use these profiles as a tool for their characterization. Seventy-six samples were collected from two olive-growing regions of Lebanon and at two harvesting times. Fatty acid composition was determined by gas chromatography with a flame ionization detector, total phenols was determined by spectrophotometry and individual phenols by high performance liquid chromatography with diode array detector. All samples were also analyzed using near infrared spectroscopy. The experimental data were collected in numerical matrices and treated by chemometric methods. The results showed the significant effect of the geographical origin, the olive variety and the harvesting time on the ripening and industrial yield of the olives and on the major fatty acids and phenols of olive oil. Moreover, the used chemometric methods allowed the discrimination of European olive varieties based on their high contents of oleic acid, oleacein and oleocanthal.
Process Simulation and Optimization of Fluid Catalytic Cracking Unit’s Rich Gas Compression System and Absorption Stabilization System
Authors: Sun Jin , Yu Haoshui , Yin Zengqi , Jiang Liangliang , Wang Li , Hu Shaolin , Zhou Rujin
Published: July 2023

In a fuel-based refinery, rich gas in the fluid catalytic cracking (FCC) unit is further processed to separate dry gas and refinery products (i.e., stabilized gasoline and liquified petroleum gas). The process is utility-intensive and costly and includes a two-stage compressor, pumps, an absorber, a stripper, a stabilizer, and a re-absorber. The optimization was conducted with respect to the compressor outlet pressure from the gas compression system (GCS) and the flow rate of absorbent and supplementary absorbent from the Absorption-stabilization System (ASS) using the process simulation software Aspen Plus. Compared to the base case of a 725 kt/a rich gas FCC unit, a refinery can save 2.42% of utility costs under optimal operation. Through optimized operation, medium-pressure steam consumption has been reduced by 2.4% compared to the base case, resulting in a significant improvement in total operational cost. The optimization strategy can provide insightful guidance for the practical operation of GCS and ASS.
Metals and Metalloid Concentrations in Fish, Its Spatial Distribution in PPC, Philippines and the Attributable Risks
Authors: Senoro Delia B. , Plasus Maria Mojena G. , Gorospe Alejandro Felipe B. , Nolos Ronnel C. , Baaco Allaine T. , Lin Chitsan
Published: July 2023

Fish is an important source of protein in human meals around the world. However, the fish that we are eating may be contaminated with toxicants such as metals and metalloids (MMs), which may pose health risks to consumers. Information on MMs content in fishes and their potential spatial distribution scenarios would provide knowledge to the community to create strategies and protect human health. Hence, this study assessed and determined the health risk levels of MMs in both brackish and marine water fish (BMF) in Puerto Princesa City (PPC), Palawan Province, Philippines. PPC has an existing abandoned open mine pit near the PPC coastline called the “pit lake”. The concentrations of As, Ba, Cu, Fe, Mn, Hg, and Zn in fishes were analyzed using portable Olympus Vanta X-ray Fluorescence (pXRF), and the spatial distribution of MMs concentrations in BMF was analyzed using a GIS (geographic information system). Fishes were sampled from fishing boat landing sites and nearby seafood markets. The results revealed that the concentration of MMs in marine fish was generally higher than the brackish water fish. It was recorded that the Hg concentration in marine water fish meat was higher than in brackish water fish meat. The Mn concentration in marine water fish exceeded the permissible limits set by international bodies. An elevated concentration of Mn in BMF was detected across the northern part of PPC, and an elevated concentration of Hg in marine fishes was recorded in the southeast area, where the fish landing sites are located. Ba was also detected in BMF across the southern part of PPC. Moreover, an elevated concentration of Cu was detected in MBF in the northeast and in marine fish in the southeastern area of PPC. Further, this paper elaborates the non-carcinogenic and carcinogenic risks of these fishes to the PPC population and tourists with respect to the MMs content in fish meat.
Determinants of Pesticide Exposure in Occupational Studies: A Meta-Analysis
Authors: Oltramare Christelle , Mediouni Zakia , Shoman Yara , Hopf Nancy B. , Graczyk Halshka , Berthet Aurélie
Published: July 2023

Few epidemiological studies use exposure determinants specifically tailored to assess pesticide or plant protection product (PPP) exposures when assessing presumed association between occupational exposure and health outcomes among agricultural workers. This lack of exposure specificity could lead to results that fail to detect an association. It could be related to the lack of consensus on exposure assessment methods and the choice of exposure determinants. We conducted a meta-analysis following the PRISMA checklist to identify PPP exposure determinants used in occupational studies and identified exposure determinants that best characterized agricultural exposures to PPPs. Out of 1436 studies identified, 71 were included. The exposure determinants identified were active ingredients, chemical classes, types of PPP, crops, tasks, frequencies, duration, lifetime exposure days, and intensity-weighted exposure days. Only six over 17 associations between exposure determinants and health outcomes were found with moderate quality of evidence. Overall, epidemiological studies had difficulty defining relevant determinants to characterize PPP exposures for agricultural workers. We recommend that a standardized list of determinants for PPP exposures in occupational exposure studies should include information on formulations, intensity, duration, and frequency of PPP exposure. Harmonized data collection on exposure and health outcomes are required as well as standard units for each exposure determinant.
Comparative Neutralization Activity of Commercial Rabies Immunoglobulin against Diverse Lyssaviruses
Authors: Coertse Jessica , Viljoen Natalie , Weyer Jacqueline , Markotter Wanda
Published: July 2023

Novel lyssaviruses, the causative agents of rabies, continue to be described mostly due to increased surveillance in bat hosts. Biologicals for the prevention of rabies in humans have, however, remained largely unchanged for decades. This study aimed to determine if commercial rabies immunoglobulin (RIG) could neutralize diverse lyssaviruses. Two commercial preparations, of human or equine origin, were evaluated against a panel consisting of 13 lyssavirus species. Reduced neutralization was observed for the majority of lyssaviruses compared to rabies virus and was more evident for lyssaviruses outside of phylogroup I. Neutralization of more diverse lyssaviruses only occurred at very high doses, except for Ikoma lyssavirus, which could not be neutralized by the RIG evaluated in this study. The use of RIG is a crucial component of rabies post-exposure prophylaxis and the data generated here indicate that RIG, in its current form, will not protect against all lyssaviruses. In addition, higher doses of RIG may be required for neutralization as the genetic distance from vaccine strains increases. Given the limitations of current RIG preparations, alternative passive immunization options should be investigated.
Apicificação em dentes com rizogênese incompleta acometidos por trauma dental: relato de caso
Authors: Verçosa Tailany Marley Alves , Da Rocha Raissa Carolina Lima Wanderley , De Oliveira Nayr Karlla Alves , Lessa Samara Verçosa , De Oliveira Adriana Pachêco
Published: July 2023

Objetivo: Descrever dois casos clínicos de pacientes distintos, com histórico de trauma dental nos elementos 11 e 21, submetidos a apicificações, onde constatou-se clínica e radiograficamente, a formação de uma barreira mineralizada na porção apical. Detalhamentos dos Casos: O primeiro caso, 14 anos, gênero feminino melanoderma, dente 11. Durante a anamnese, a responsável relatou que a adolescente havia sofrido um trauma dentário há cerca de 7 anos, porém nunca apresentou sintomatologia dolorosa, e que já havia sido realizado um procedimento endodôntico há 2 anos. O segundo paciente, gênero masculino, 8 anos, leucoderma, compareceu à clínica - escola, com histórico de trauma no elemento 21 há cerca de 5 meses. Após a realização dos exames clínicos e radiográficos, foi planejado um tratamento de apicificação para ambos. Considerações finais: A execução e o acompanhamento destes casos clínicos demonstrou que a apicificação é uma opção de tratamento que possibilita a obturação e manutenção dos dentes com rizogênese incompleta e necrose pulpar precoce, e que o emprego dos biomateriais é um recurso muito importante para um resultado satisfatório.
APPLYING FIELD PROGRAMMABLE GATE ARRAYS IN SYSTEMS OF MULTICHANNEL DIGITAL PROCESSING OF SATELLITE NAVIGATION SIGNALS
Authors:   Military Educational and Scientific Centre of the Air Force N. E. Zhukovsky and Y. A. Gagarin Air Force Academy, Voronezh, Russia, Богословский А. В. , Разиньков С. Н. ,   Military Educational and Scientific Centre of the Air Force N. E. Zhukovsky and Y. A. Gagarin Air Force Academy, Voronezh, Russia, Сёмка Э. В. ,   Military Educational and Scientific Centre of the Air Force N. E. Zhukovsky and Y. A. Gagarin Air Force Academy, Voronezh, Russia, Буслаев А. Б. ,   Military Educational and Scientific Centre of the Air Force N. E. Zhukovsky and Y. A. Gagarin Air Force Academy, Voronezh, Russia
Published: July 2023

The study analyzes multichannel digital satellite navigation signal processing systems for unmanned aerial vehicles. To advance interference insusceptibility of navigation equipment on the basis of adaptive change in settings, it is advisable to apply a field programmable gate arrays in order to implement variations of algorithms of signal processing without reconfiguring the equipment’s structure in changes in radioelectronic settings. A navigation complex with the function of interference insusceptibility is developed based on the field programmable gate arrays. It may simultaneously receive signals from such satellite navigation systems as GLONASS, GPS, QZSS, BeiDou, Galileo, and NavIC via four independently tuned channels and their digital processing using adaptive filtering algorithms. Patterns in spatial selectivity of signals are studied, as are the possibilities for navigation equipment adaptability in interference settings using programs for electrodynamic modeling of adaptive antenna arrays ‒ SolidWorks, Altium Designer, and Quartus.
MATHEMATICAL SIMULATION OF FREQUENCY CONVERTER WITH SPACE VECTOR PULSE WIDTH MODULATION
Authors:   Belgorod State Technological University named after V. G. Shukhov, Belgorod, Russia, Саввин Н. Ю. , Гарбузов Д. Д. ,   Belgorod State Technological University named after V. G. Shukhov, Belgorod, Russia
Published: July 2023

The article presents the stages of developing and building a mathematical model for a semi-conductor frequency converter with space vector pulse width modulation, which consists of a power circuit made of power semiconductor elements. The mathematical simulation is performed in the MATLAB/Simulink soft-ware environment. The main principles of the model’s components performance are formulated. Using switching diagrams, calculated data for building a functional management system for the power keys of a frequency con-verter are presented. Based on the simulation results, oscillography records of phase and linear load voltages are obtained. Dependences of output voltage quality on the frequency of pulse width modulation are identified. The main advantages of using space vector pulse width modulation are described in designing sinusoids of output voltage in a frequency converter when working with an active inductive load. The authors draw conclusions on the usage of the vector method for building an output voltage of a frequency converter in the industry.
صور من الخصائص الفنية في خطب الشيخ عبدالكريم يحيى دراسة أدبية
Authors: Bakura Dr Muniru Muhammad , Bashir Dr Abdulkafi Usman
Published: July 2023

This paper is titled “Selected Rhetoric from of the Sheikh Abdulkarim Yahaya; Presentation and Analysis.” It is a study of the art of rhetoric, which is a style of artistic prose that depends on the audience’s attention. It aims at persuading and influencing the mind of the listeners. The Arabs have found in it (rhetoric), the best way to incite fighting and arouse enthusiasm. With it, the Arabs proud in their scenes, (with it) theء caliphs and emirs spoke on their pulpits, (with it) speech is distinguished, it is the one by which the generality of the public and privates are addressed. Since Islam was an intellectual, social, political, and economic revolution, it must have an impact on rhetoric. So rhetoric flourished in this era (i.e. present era) because Islam needed it as an important and powerful tool.
ألفاظ الأخلاق الحميدة وعلاقاتها الدلالية في قصيدة جمع الخردة لإبراهيم أحمد مقري : د ا رسة تحليلية
Authors: J Abdullah Azar , Musa Abdullah
Published: July 2023

Semantic field is, indeed, a group of lexemes containing more concepts under one main conceptual meaning uniting the field; the words therein, were conjoined together as they are inter-related in meanings by the degree of semantic convergence, it is also characterized by common semantic features and, acquires its meanings in its relations to other words. Because; one word has no meaning on its own, rather, its meaning is determined by searching it with the closet words under one group. Vendees explained this fact by saying: “The mind tends to collect words, and to discover new bond that combine them together, as words are always proven by linguistic family”. This paper is a statement of the field of words of good manners and their semantic relations contained in the poem “Jam’ Elkharda” written by Ibrahim Ahmad Maqary, which is a quintupled stanzas of “Al-burdah” by Al-busairy in the prophetic praise model, as well as the seventh poem in the Divan ‘Khulaasat El-Ishriniyyaat”. The research pointed out a number of words indicating good morals, as such, they were studied and analyzed according to the semantic fields theory. The underlying semantic relations between these terms are either synonymous, antonyms, inclusion, dissonance, or the relationship of part of a whole.
CATHETER-ASSOCIATED URINARY TRACT INFECTIONS AFTER CAESAREAN SECTION IN UKRAINE: RESULTS A MULTICENTER STUDY (2020-2022)
Authors: Salmanov Aidyn G. , Artyomenko Volodymyr , Susidko Olena M. , Korniyenko Svitlana M. , Kovalyshyn Orusia A. , Voloshyn Oleksandr A. , Golyanovskiy Oleg V.
Published: July 2023

The aim: To obtain the first national estimates of the current prevalence rate of catheter-associated urinary tract infections (CAUTIs) after caesarean section (CSEC) and antimicrobial resistance of causing pathogens in Ukraine.
Materials and methods: Prospective multicentre surveillance was conducted from January 2020 to December 2022 in 15 women hospitals of Ukraine. Definitions of CAUTIs were adapted from the CDC/NHSN. Antibiotic susceptibility was done by the disc diffusion test as recommended by European Committee on Antimicrobial Susceptibility Testing guidelines.
Results: A total of 15,892 catheterized women undergoing primary CSEC and 13.6% CAUTI were identified. The most common uropathogen was Escherichia coli, Proteus mirabilis, and Enterococcus species followed by Providencia stuartii and Pseudomonas aeruginosa. Many uropathogens isolated from CAUTI cases were found to be multidrug resistant.
Conclusions: This study showed that CAUTIs in catheterized women undergoing primary CSEC in Ukraine is a common occurrence and many cases are caused by pathogens that are resistant to antibiotics. Optimizing the management and empirical antimicrobial therapy may reduce the burden of CAUTIs in catheterized women undergoing primary CSEC, but prevention is the key element.
INTERNATIONAL EXPERIENCE OF STATE SUPPORT OF SMALL AND MEDIUM-SIZED BUSINESSES
Authors:   Institute of Public Administration and Management of the Russian Presidential Academy of National Economy and Public Administration, Moscow, Russia, Gevorgyan Lilit S. , Gonenko Daniil V. ,   Institute of Public Administration and Management of the Russian Presidential Academy of National Economy and Public Administration, Moscow, Russia
Published: July 2023

The article is devoted to the practice of implementing cluster policy abroad – the experiences of the member countries of the Organization for Economic Cooperation and Development (OECD). The research in this article can be used to create effective tools to support small and medium-sized businesses in the Russian Federation. The world economy is constantly changing, and new trends, technologies and working methods are emerging in practice. The use of the experience of developed countries will help to promote the development of small and medium-sized enterprises in the Russia. The most successful countries in terms of implementing cluster policy create specialized structures (implementation agency) that provide high-quality support services to (non-financial) cluster management organizations. Some key success factors of additional support services have been identified: high demand orientation, practical orientation of support measures and their high quality, training with the possibility of exchange of experience and establishment of links with other services, communication and consistent implementation based on stable principles. The authors’ observation of the activities of domestic clusters, analysis of foreign experience and theoretical literature allowed to highlight some conditions of sustainable development of clusters, in particular, the quality of the environment, the level of profile companies, the predominance of private initiative, Openness and internal competition, as well as the presence of specialized independent management bodies and active working groups. Compliance of the cluster with these features will allow it to move to a self-development trajectory.
EMPIRICAL STUDY OF KEY GOALS AND DRIVERS OF DIGITAL TRANSFORMATION OF ENTERPRISES IN MODERN CONDITIONS
Authors:   Saint-Petersburg State University of Aerospace Instrumentation, St. Petersburg, Russia, Trofimova Natalya N.
Published: July 2023

The article explores the key goals and drivers of the digital transformation of enterprises. Based on empirical data on digital transformation, questions are considered regarding the reasons that encourage enterprises to implement digital transformation and its impact on the activities of organizations.
PEMBELAJARAN MENULIS TEKS EKSPLANASI MENGGUNAKAN MODEL PROBLEM BASED LEARNING BERBANTUAN MEDIA ARTICULATE STORYLINE DI KELAS VIII SMP BIMASENA SCHOOL
Authors: Ine Sachintania  , Eggie Nugraha  , Marlia
Published: July 2023

This study is motivated by the low skills and interest of students to write and Indonesian language learning becomes boring, less interesting, and seems monotonous because of the selection of models and media that are not appropriate. This research aims to describe: (1) how students learn to write explanatory texts in Class VIII SMP Bimasena School before using the problem-based learning model assisted by articulate storyline media; (2) how students learn to write explanatory texts in Class VIII SMP Bimasena School after using the problem-based learning model assisted by articulate storyline media; (3) the difference in the ability to write explanatory texts of students in Class VIII SMP Bimasena School in the experimental class and control class using the problem-based learning model assisted by articulate storyline media. The method used, namely pure experiment with pretest-posttest control group design. The results of this study, namely: (1) the value of experimental class students has not met the minimum completeness criteria that have been determined before applying the problem-based learning model assisted by articulate storyline media, this can be proven from the average value and recapitulation of the value that the average pretest of the experimental class is 17.3; (2) the value of experimental class students has met the predetermined minimum completeness criteria after applying the problem-based learning model assisted by articulate storyline media, this can be proven from the average value and recapitulation of the value that the average posttest of the experimental class is 86.5; (3) the experimental class has a higher value compared to the control class after receiving treatment, this can be proven from the recapitulation of the pretest and posttest and seen from the results of the independent sample t-test test, the Sig. (2-tailed) value is 0.001 <0.05.
The Quality Performance of Manufacturing Companies in West Java: SCM, TQM, and JIT Impact
Authors: Pratiwi Nurul Aziz , Susilowati Ervan , Syukriah Syukriah , Pianda Didi , Susanti Erna
Published: July 2023

This study aims to analyze the impact of supply chain management (SCM), total quality management (TQM), and just-in-time (JIT) practices on the quality performance of manufacturing companies in Jawa Barat, Indonesia. The manufacturing sector in Jawa Barat plays a crucial role in the regional economy, making it imperative for companies to maintain high-quality standards to remain competitive. Data were collected through surveys and interviews from a sample of 40 manufacturing companies in Jawa Barat. The analysis included statistical techniques such as t-tests and F-tests to examine the relationships between SCM, TQM, JIT, and quality performance. The results indicated that SCM, TQM, and JIT practices have a significant positive influence on quality performance. The calculated t-values and F-value were found to be greater than the critical values, indicating statistical significance. Furthermore, the Adjusted R Square value of 0.669 suggests that 66.9% of the variance in quality performance can be attributed to the combined influence of SCM, TQM, and JIT. These findings underscore the importance of implementing effective SCM, TQM, and JIT practices to enhance quality performance in manufacturing companies. By optimizing supply chain processes, fostering a culture of continuous improvement, and implementing lean production methods, companies can achieve higher product quality, customer satisfaction, and operational efficiency.
Manejo quirúrgico de biopolímeros en punta nasal: reporte de caso y revisión de la literatura
Authors: Thomas Laura Sofia , González Claudia , Heredia Nicolás
Published: July 2023

Los rellenos faciales han sido ampliamente utilizados a nivel mundial. Existen rellenos temporales, semipermanentes y permanentes. En cuanto a los rellenos permanentes, la silicona es la más utilizada y está aprobada por la agencia gubernamental de los Estados Unidos, la Administración de Alimentos y Medicamentos (FDA) en dos presentaciones para el desprendimiento de la retina. En 1997 se autorizó el uso off-label de Adatosil y Silicon 100, ambas prescritas durante la relación médico-paciente. Se han descrito múltiples eventos adversos secundarios a la inyección de silicona como relleno facial, principalmente síntomas inflamatorios, reacción a cuerpo extraño, sepsis y migración del producto, que por lo general se presentan por una aplicación inapropiada por personal sin entrenamiento. Caso clínico: se presenta el caso de un paciente masculino en la quinta década de la vida, a quien le aplicaron silicona en aceite a nivel de la punta nasal; posteriormente, presenta dermatopatía secundaria sin respuesta
Cribado virtual de metabolitos secundarios de Origanum vulgare y mejorana frente a NaV1.7 como anestésicos promisorios asociados a la vía neurosensitiva auditiva
Authors: Vélez-Duncan Carlos Arturo , Uribe-Escobar Alejandro , Pineda-Alemán Rafael , Contreras-Puentes Neyder , Alviz-Amador Antistio
Published: July 2023

Introducción: en general, el orégano es una planta medicinal usada en los pueblos de la costa Caribe colombiana para tratar afecciones del aparato respiratorio y el oído externo debido a su potencial efecto antiinflamatorio, analgésico y antiséptico; sin embargo, esto no se ha validado mediante ensayos clínicos. Objetivo: realizar un cribado virtual basado en el acoplamiento molecular de metabolitos secundarios identificados en el Origanum vulgare y mejorana frente al receptor Nav1.7 para evaluar el potencial efecto anestésico a nivel del oído externo. Método: el presente es un estudio in silico con un enfoque de cribado virtual por acoplamiento molecular, para lo cual se usó el software AutoDock Vina y para las predicciones farmacocinéticas se usó la herramienta en línea SwissADME del Swiss Institute of Bioinformatics (http://www.sib.swiss). Adicionalmente, se evaluó la toxicidad in silico de las moléculas utilizando el servidor GUSAR-Online. Resultados: de las 99 moléculas que fueron evaluadas por acoplamiento molecular se evidenció que las mayores afinidades con respecto al canal Nav1.7 fueron el ácido clorogénico, la rutina, la luteolina, el luteosido y la apigenina, donde se presentaron energías de afinidad con el sitio de unión en el poro central del canal a valores entre -5,40 ± 0,00 a -5,57 ± 0,06 kcal/mol;
de estos, de acuerdo con el análisis ADMET y GUSAR, solo el ácido clorogénico, la luteolina y la apigenina son buenos candidatos potenciales para fármacos anestésicos ya que cumplen con las cinco reglas de Lipinski.
Can Events Impact on Social Connectedness and Loneliness? An Analysis of Face-To-Face and Virtual Events Attended in South Australia
Authors: Kitchen Eliza , Son Insun Sunny , Jones Julia J.
Published: July 2023

Festivals and events can be a platform for interactions and social connections. More recently, events have been linked to social well-being, assisting in reducing loneliness and increasing social connectedness. However, with the emergence of COVID-19, event attendance has been altered
as people have been restricted from attending face-to-face events and virtual events have become a popular mode of events. This study, therefore, aims to examine whether the frequency and mode (face-to-face and virtual) of event attendance influence attendees’ feelings of loneliness and
social connections. The survey results reveal the significant relationship between face-to-face event attendance and social connectedness. In contrast, the frequency of virtual event attendance was not found to have a significant effect on social connectedness or loneliness. The type of face-to-face
and virtual events attended was also reported in the study, providing us with some understanding of event attendance amongst changing times.
Preparation and Characterization of L-ascorbic Acid Ethosomal Formulation for Enhancement of Permeation
Authors: Alabada Ahmed , Mohammed Murtadaa
Published: July 2023

Background: Vesicular system is a good approach to improve hydrophilic drug permeability using phospholipids as Nanocarriers to increase lipophilicity and reduce vesicle size. L-ascorbic acid is a water soluble vitamin with antioxidant activity with poor skin permeability. Aim: The purpose of this work is to prepare LAA-containing ethosomes formulations utilizing a modified thin film hydration approach. Methods: eight formulas were prepared using different types of phospholipids (egg yolk lecithin and soya lecithin), different volumes of ethanol (2 and 3mL), and tween 80 as a surfactant. The prepared formulas (F1, F2, F3, F4, F5, F6, F7 and F8) were characterized to detect the best one regarding the physical appearance, pH, average vesicle size, polydispersity index (PDI) and entrapment efficiency. Scanning electron microscope (SEM) and transmission electron microscope (TEM) were used to evaluate the morphological properties Results: The best prepared ethosomal formula was F3 which contains (1.5g) LAA, (0.1 g) egg yolk lecithin, (2 mL) ethanol, 0.025 mL tween 80 and (q.s.10mL) of distilled water. Its average vesicle size value (176nm), PDI = 0.243, high entrapment efficiency (89.8%) and good physical stability. The morphological properties showing spherical, smooth, and devoid of drug crystalline structures.  The drug-excipient compatibility is confirmed using (FTIR, DSC and PXRD) analyses. Additionally, the Ex-vivo drug permeation investigation demonstrated that the prepared formula of LAA had flux and permeability coefficients that were two times higher than the control. Conclusions: The average vesicle size and PDI are affected by, the volume of ethanol, type of lecithin and presence of solubilizing agent.