bluuebunny/crossref_metadata_2025 huggingface dataset:
Revolutionizing FDA’s Quality Assessment of Regulatory Drug Applications with Knowledge-Aided Assessment and Structured Application (Kasa): An Innovative Approach
Authors: D Prasanthi
Published: January 2024

The regulatory evaluation process used by the FDA has changed through time, moving from a summary-based review in the 1990s to a question-based review and risk-based approach in the 2000s, and finally to an integrated quality assessment in 2015 and beyond. While attempting to ensure effectiveness, uniformity, and objectivity in its oversight of pharmaceutical quality, the FDA has faced difficulties. The FDA is developing a new approach called Knowledge-aided Assessment & Structured Application (KASA) to address these issues and make the most of technological advancements. The KASA system is intended to: 1) capture and manage knowledge throughout the lifecycle of a drug product; 2) develop rules and algorithms for risk assessment, control, and communication; 3) perform computer-aided analyses of applications to compare regulatory standards and quality risks across applications and facilities; and 4) provide a structured assessment that reduces textbased narratives and summarization of provided information. KASA is a new system designed to update the regulatory drug applications’ quality evaluation. KASA represents a conceptual change away from the out-dated evaluation procedures and toward a fresh, more effective method of managing data and resources. When completely developed and put into use, KASA will improve regulatory quality oversight’s efficacy, efficiency, and consistency through the lifecycle management of products and facilities and the sharing of information in a standardized and organized format. KASA will ultimately increase FDA’s emphasis on pharmaceutical quality, which is the cornerstone for guaranteeing the safety and efficacy of medications.
Sound Wave Digital Learning Material Integrated Augmented Reality and CTL Model to Promote Students' 21st Century Skills
Authors: Jessica Alfa  , Asrizal
Published: January 2024

The learning process should be able to develop students' 21st century skills. In fact, students' 21st century skills are still low. Skills in the 21st century that need to be developed by students are 4C abilities, including: critical thinking and communication. The purpose of this research is to analyze the results of the needs analysis, the results of the validity test, and the results of the practicality test of digital learning materials to support the improvement of students' 21st century skills. The type of research used is R&D with the Hannafin and Peck model. The subjects in this study were students of class XI senior high school. The instruments used are questionnaires, test questions, and performance assessment to analyze student needs; product validation sheets to determine product validity; and product practicality sheets to determine the practicality of product use. The data analysis used in this research is descriptive statistical analysis. The validity test data analysis was conducted using Aiken's V formula. The validity analysis results show that the average validation value of AR-CTL digital learning materials is in the valid category. The practicality analysis value of AR-CTL digital learning material is in the practical category. So, it can be concluded that the augmented reality digital learning material integrated with the CTL model are valid and practical to promote students' 21st century skills.
Interactive Media Articulate Storyline to Improving Students’ Learning Outcomes on Traditional Engklek Games Material
Authors: Milenia Rindita , Nurharini Atip
Published: January 2024

The application of traditional games in learning is still rarely implemented in elementary schools. Therefore we need learning media that is able to introduce traditional technology based on technology that is interesting for students. This study aims to analyze the effectiveness of interactive learning media Articulate Storyline in improving learning outcomes in fourth grade students Movement material on Traditional Engklek Games. The type of research used is research and development that refers to the ADDIE model. Determination of internal media validity is done by carrying out validation to experts and practitioners of media and material. Effectiveness is then determined by conducting small scale and large scale tests through pretest and posttest. The t-test results showed that the sig. value (2-tailed) is 0,000 meaning < 0.05. The N-Gain test shows a value of 0.69 with a medium category, so it can be concluded that there is an increase in the average value of the pretest and posttest. The conclusion of this study is that the interactive learning media Articulate Storyline is useful and effective used to improve the learning outcomes of fourth grade students on Movement on Traditional Engklek Games.
Implementation of Mobile Learning Design in the Flipped Direct Instruction Model to Increase Student Competency Using a Constructivist Approach
Authors: Irfan Dedy , Lativa Mursyida  , Akrimullah Mubai
Published: January 2024

Mobile learning using technology is the main challenge for Generation Z students today. This challenge will affect students' independence and ability to learn. For this reason, this research aims to test the implementation of mobile learning using the Flipped Direct Instruction (FDI) model and develop Jarkom FDI learning media using a constructivist approach. This type of research is Quasi-Experimental Research. The control class and experimental class were used in this research. The Direct Instruction (DI) model is applied in the control class, and the FDI model is used for the experimental class. This research uses quantitative and primary data types. The methods used to collect data are questionnaires and tests. The instruments used to collect data were questionnaires and question sheets. The techniques used to analyze data are qualitative and quantitative statistical analysis. Data was obtained using test instruments and calculated using the Gain Score method. The results of the research are Jarkom FDI learning media along with mobile learning implementation data. This data obtains a percentage of the Gain Score, namely 75.04%, with a minimum percentage of 61.7% and a maximum percentage of 100.0%. 75.04% answered the research hypothesis that there is a significant influence of implementing mobile learning design in the FDI learning model with a constructivist approach on the results of computer network installation practicum learning. It was concluded that the learning model that uses mobile with a constructivist approach effectively improves students' cognitive and psychomotor abilities. The results of this study are expected to be one of the qualified options for increasing the effectiveness of the implementation of Computer Network Installation learning.
Needs Analysis: Development of Contextual Approach Learning Tools Based on Local Balinese Wisdom
Authors: Wibawa I Made Citra , I Gede Margunayasa  , Ni Wayan Eka Widiastini
Published: January 2024

Lectures are textual, and students have yet to actively participate in learning activities actively, making learning less meaningful. This research analyses the need for developing contextual approach learning tools based on local Balinese wisdom. This research is survey research. The methods used to collect data are questionnaires, interviews, observation and document study. The instrument used to collect data was a questionnaire sheet. The technique used to analyze data is qualitative descriptive analysis. The research results are, first, that the approach applied in science skills development courses has yet to be effective. Second, one of the difficulties currently experienced by lecturers is that science learning material needs to be connected to the local context or wisdom. Third, lecturers understand the concept of contextual learning, but learning implementation still needs improvement. One of the things that causes learning activities with contextual concepts to be less than optimal is that they need to be integrated or included in the semester lecture plan. Fourth, a contextual approach will have a positive impact that will improve the learning experience. Fifth, using a contextual approach in learning science skills in elementary school helps students understand and apply it to their lives. It was concluded that developing learning tools with a contextual approach based on local wisdom is very important.
Analysis of the Genetic Diversity in Indian Mustard (Brassica juncea L. Czern&Coss) Genotypes
Authors: CHAUHAN RAHUL SINGH , Kumar Mukesh , Kumar Shubham , Tiwari Mayank , Tiwari Utkarsh
Published: January 2024

A study was undertaken during the rabi season (October, 2021 to March, 2022) at the crop research center Sardar Vallabhbhai Patel University of Agriculture and Technology Meerut, Uttar Pradesh, India to find out the genetic divergence in 40 genotypes of Indian mustard using the D2 statistical approach.  Forty (40) diverse genotypes of Indian mustard were examined for genetic divergence using a randomized complete block design (RCBD) with three replications. Observations were recorded on various 14 characters viz; days to 50% flowering, days to maturity, plant height (cm), number of primary branches plant-1, number of secondary branches plant-1, siliquae on main axis, length of main axis (cm), siliqua length (cm), number of seeds siliqua-1, 1000 seed weight (g), biological yield plant-1 (g), harvest index (%), oil content (%) and seed yield plant-1 (g). Mahalanobis D2 statistics were applied to the analysis of genetic divergence. Based on D2 values 40 genotypes were grouped into 5 clusters, maximum genotypes eleven obtained in cluster IV after that cluster I with nine genotypes, cluster V with eight genotypes, cluster III with seven genotypes and cluster II with five genotypes. The maximum intra-cluster was in cluster IV. The maximum inter-cluster distance was revealed between cluster II and V. It is clearly indicated that the genotypes included in this cluster are having a wide spectrum of genetic diversity. According to the role of many traits under examination in the manifestation of genetic divergence, plant height had the biggest contribution to divergence.
Socioeconomic Services of Khampti Tribe of Arunachal Pradesh Concerning Introduction of Homestead Agroforestry
Authors: Hazarika Prosanta , Kotoky Malaskiva , Suman Mayur , Hazarika Protul
Published: January 2024

A socioeconomic survey was done during (2019–2022) in 15 villages of the Khampti tribe of Namsai, Arunachal Pradesh, India. A questionnaire was prepared and interviewed the households about socioeconomic, life style, livelihood, education, primary livelihood activity, land holdings and land use pattern, energy consumption, livestock profile etc.To compare the profitability of different land uses, the annual profit was calculated. More than 50% of the households were lived in kaccha houses, 32% live in semi pucca houses and 15% had pucca houses. Average annual income of the households was maximum (25%) within the range of ` Rs. 15,000–20,000; 23% incomes more than ` 40,000; while 5.3% within the range of `Rs. 10,000–15,000. About 66.66% households were depended on agriculture for their livelihood. Similarly, 20% households were depended on both agriculture and government job, whereas, 1.77% households were dependent only on government jobs and 0.88% on business. 50% population completed their studies up to class 10; 22% had their secondary education (class 12) and few (4.64%) had done post-graduation. Average 73.87% of the total land was used as agricultural land and 25% as homestead land. Cow was the highest reared livestock than pig, goat and buffalo. Annual energy consumption was recorded for LPG (67.55%), fire wood (17.34%) and kerosene (15.11%). Further, their homesteads do not have agroforestry planning to optimize land use. Therefore, we developed five agroforestry demo plots in Namsai district. In the initial years (2020–2022) of agroforestry could enhanced economic return up to 3 times and also widen the livelihood options.
Impacto del teletrabajo en el estrés laboral de docentes universitarios por el covid-19
Authors: Benítez Salinas Denia
Published: January 2024

La presente investigación tuvo como objetivo analizar el impacto del teletrabajo en el estrés laboral de los docentes universitarios por la pandemia del covid-19, así como establecer la relación entre agotamiento laboral y estrés laboral. Para ello, se utilizó una metodología cuantitativa, de tipo descriptiva y correlacional. El diseño de investigación fue no experimental de forma transversal debido a que solo se recolectaron datos durante el periodo de confinamiento, en los meses de agosto y septiembre de 2021. La población de estudio fueron los docentes de la Universidad Autónoma del Estado de México. Los resultados revelan que el teletrabajo a causa de la pandemia del covid-19 provocó en una proporción mayoritaria de docentes universitarios un nivel leve de estrés laboral y un nivel medio de agotamiento laboral. Los principales síntomas asociados al estrés laboral que manifestaron los docentes fueron molestias gastrointestinales y dolores de cabeza. Además, las mujeres docentes presentaron mayores niveles de estrés, en comparación con los hombres. En definitiva, según los resultados, el estrés laboral se correlaciona de forma significativa, positiva y alta con el agotamiento laboral.
Burnout por covid-19 durante las clases en línea en estudiantes universitarios
Authors: Sandoval-Caraveo María del Carmen , Surdez-Pérez Edith Georgina , Pérez-Sandoval Abraham Gerardo
Published: January 2024

Una de las medidas adoptadas por los gobiernos para preservar la salud de las personas durante la pandemia por covid-19 fue la implementación del distanciamiento físico. Esto obligó a las universidades a transitar de las clases presenciales a las clases en línea, lo que generó un panorama incierto para los estudiantes. Por ende, el propósito de esta investigación fue identificar la proporción de estudiantes que experimentaron el síndrome de burnout durante las clases en línea impartidas durante la pandemia. Para ello, el estudio se enfocó en una población de estudiantes universitarios de diversas áreas del conocimiento en una universidad pública ubicada en Tabasco, México. La investigación se llevó a cabo mediante un enfoque cuantitativo y descriptivo, con un diseño no experimental de tipo transversal. Para recopilar datos, se utilizó un cuestionario elaborado en Google Forms, que fue administrado de manera voluntaria a 268 estudiantes. Asimismo, se aplicó un análisis factorial exploratorio para validar el instrumento, y la confiabilidad se evaluó mediante el coeficiente alfa de Cronbach que arrojó un valor de α = 0.950. Los hallazgos indicaron que los porcentajes más altos de burnout se identificaron en las dimensiones de agotamiento y despersonalización. Esto se atribuyó a las dificultades para prestar atención durante las clases en línea, el agotamiento causado por las demandas académicas, el estrés asociado con las tareas, la falta de sueño debido al trabajo escolar y las dificultades en la comunicación con los profesores cuando surgían dudas sobre las clases. En general, los resultados señalaron que más de la mitad de los estudiantes presentaron baja realización personal, agotamiento y despersonalización. Por tanto, se concluye que estos datos representan una alerta en la población estudiada, y subrayan la necesidad de implementar medidas dirigidas a reducir el burnout en los estudiantes. Además, se sugiere realizar investigaciones adicionales al regreso de las clases presenciales para evaluar la presencia del burnout en ese contexto.
Inteligencia espiritual y neurociencia en el proceso de la motivación para el aprendizaje
Authors: Dávalos Hernández Argelia
Published: January 2024

Al ingresar a la escuela, los alumnos se enfrentan a dos procesos distintos que deben comprender: el contexto social que se genera dentro del aula al explicar nuevos conocimientos y los contenidos que deben estudiar. Esto los coloca en una situación de incertidumbre al intentar desarrollar nuevas formas de aprender o conectar sus experiencias de aprendizaje, y al emplear de manera empírica sus criterios, reflexiones y valores, lo cual, en ocasiones, puede resultar no grato y crear desinterés por el aprendizaje. Por ende, el propósito del presente ensayo es mostrar cómo, a través del manejo de la inteligencia espiritual y la neurociencia, los maestros pueden lograr desarrollar la motivación en el proceso de enseñanza-aprendizaje. Para ello, utilizando la inteligencia espiritual y la neurociencia, se busca potenciar la capacidad de los estudiantes para discriminar posibilidades que contribuyan a la resolución de situaciones de aprendizaje. Esto se logra mediante la aplicación de estrategias integrales que estimulan el pensamiento serial, asociativo y unificador. De esta manera, se movilizan estructuras neuronales mentales, emocionales y espirituales en la sincronía de la asimilación, que sirven para identificar cómo actúan los neurotransmisores que intervienen directamente en los diferentes tipos de memoria. Esto se logra a través del conocimiento del funcionamiento de los hemisferios cerebrales, las neuronas espejo y la plasticidad neuronal. Todo ello depende de los aprendizajes que el docente desee establecer en las actividades presentadas a los alumnos con el fin de lograr la reestructuración cognitiva que posibilite la empatía con el conocimiento y favorezca las habilidades de aprendizaje en los estudiantes.
AN EXPOSITION OF ISLAMIC SOLUTIONS TO CHALLENGES FACING MUSLIMS IN TARABA STATE (1991-2021)
Authors: Ali Bello
Published: January 2024

Taraba State is heterogeneous consisting of several ethnic groups with divergent historical origins, cultural activities, and religious belief systems. The different communities actively participate in collective endeavours such as agriculture and developing essential infrastructure including culverts, houses, and schools. However, after the creation of the State, the atmosphere of harmonious coexistence started to shift towards hostility. The study aimed at the comprehensive exposition of Islamic solutions to challenges facing Muslims in Taraba. This study's primary and secondary data were derived principally through structured interviews, participatory observation, and analysis of documentary sources. The study made some significant findings, including a cordial relationship between Muslims and non-Muslims. The challenges identified include internal divisions, limited political influence, self-centeredness and animosity within the Muslim community, flawed approaches of some scholars, and a decline in moral values among Muslims. Ethnic identity, indigeneity, and minority issues also contribute to the challenges. To address these challenges, the study recommends efficient Da’wah activities, the establishment of unified leadership, the revitalization of moral teachings, and the implementation of Islamic endowment (Waqf) practices. The effective implementation of these recommendations can help mitigate the challenges faced by Muslims in Taraba State.
TASMI' BIL GHOIB ASSESSMENT MODEL OF THE QUR'AN FOR CHILDREN: CASE STUDY IN MULTICITY
Authors: Suwardi S , Anif Sofyan , Waston W , Owa-Onire Uthman Yusuf Olawale
Published: January 2024

This study aims to describe the al-Qur'an Tahfiz Assessment Model and the effectiveness of its implementation. This case study research was conducted in three elementary schools that have a Holy Scripture memorization program. The data sources for this research were school principals, curricula deputy heads, tahfiz program coordinators, tahfiz teachers, students, and students' families. Data were collected by interview, observation, and documentation techniques and analyzed using a descriptive interpretative model proposed by Miles, Huberman, and Saldana, involving data collection, reduction, presentation, and conclusion. The results of the study show the following: (1) There are three models of memorization assessment used in all these schools, namely assessment based on type, period and achievement results. (2) There are 3 aspects of similarity in the assessment model applied, namely based on type, period and results. The difference is in the implementation where each has standards including a) aspects assessed; b) valuation techniques; c) assessment time; d) target assessment; and e) tone standards. (3) The assessment model is measured from the psychological effectiveness of the students, the spiritual of the students is effective, and the result of the most effective memorization is tasmi' bil ghoib because it is thorough and traceable. The conclusion that can be drawn from these findings is that the tasmi' bil ghoib assessment model is very effective for application in elementary schools because this method takes into account the psychological and spiritual factors of students so that the student's memorization results are fairly even and the memorization results are maximized.
IMPLEMENTATION OF DIFFERENTIATED LEARNING IN ISLAMIC STUDIES AND ETHICS IN SECONDARY SCHOOLS
Authors: Sukardi S , Inayati Nurul Latifatul
Published: January 2024

The challenges of today's world of student learning are increasingly dynamic, this is characterized by different student interest tendencies and characters. The government, through the Ministry of Education, is aggressively discussing the concept of an independent curriculum through differentiated learning which is considered appropriate for achieving learning goals. This research aims to find out how the implementation of differentiated learning is applied to PAI subjects at Muhammadiyah Lasem Middle School. This research is based on qualitative methods, where this method is applied by collecting data such as interviews, observations, documentation, and/or other important records. With the research results stated. Firstly, teacher Pai carried out student profile mapping, secondly, the teacher carried out differentiated learning strategies, and thirdly, evaluated learning outcomes. One of the successes of differentiated learning is also supported by good cooperation between the class teacher and student parents in equalizing perceptions.
The Main Approaches to Implementation of the Import Substitution Policy: Analysis and Lessons Learned
Authors: Chesheva Darya K. , Melenkin Vladislav L.
Published: January 2024

The comparative analysis of approaches used in different countries of the world for implementation of the import substitution policy is carried out. The attention is focused mainly on comparing the specific features of the Latin American, East Asian and mixed models of import substitution. With

regard to the Russian experience of transfer to such a policy, which has, to a greater extent, a coercive nature, the need to direct it towards the innovative development has been stated.
The Geosystem Paradigm of Regional Socio-Ecological and Economic Development
Authors: Cheshev Anatoly S. , Shumeiko Marina V.
Published: January 2024

The expediency of using a geosystem approach to the analysis of processes taking place in the frame of the regional socio-economic systems is substantiated. The key features and properties of geosystems are highlighted, and the main contradictions of such systems at the regional level are identified.

Based on the results of the conducted analysis, it is stated that the geosystem paradigm of regional development ensures formation of quite a holistic perspective thereof by taking into account the interrelation of the natural, economic and social processes and phenomena, in the context of their dependence to the specific features of a certain territorial space where they get manifested.
Artificial Land Plot and Its Relevance in the Territorial Planning System
Authors: Ovchinnikova Natalia G. , Primakova Anastasia S.
Published: January 2024

Artificial land plots represent an important aspect of modern territorial planning. They can solve the problem of land scarcity, foster the design of the innovative projects, enhancement of the environmental sustainability, development of the infrastructure and civil construction. However, there exist certain challenges and risks related to the use of the artificial land plots. But, on the whole, the inclusion of the artificial land plots in the territorial planning system is a relevant and important objective that requires thorough analysis and consideration of many aspects — from the environmental sustainability to social value.
EFL PRE-SERVICE TEACHERS’ SELF-EFFICACY BELIEFS DURING TEACHING PRACTICUM
Authors: Cania Meta , Kusriandi Wendi , Dwiniasih Dwiniasih
Published: January 2024

The purpose of this study is to look into pre-service EFL teachers' self-efficacy beliefs about teaching English as they progress through their teaching practicum. The study's findings were gathered through a survey of 20 pre-service EFL teachers enrolled in the Faculty of Education at one of Cirebon's private universities. Teachers' Sense of Efficacy Scales of 24 questions were used to gather data, which evaluates pre-service teachers' self-efficacy on three subscales: student engagement, instructional strategy, and classroom management. The results were analyzed using descriptive statistics to determine which EFL pre-service teachers had the highest and lowest levels of self-efficacy. The study's findings revealed that their self-efficacy is at a medium level, and they are more effective in terms of instructional strategy. The study of self-efficacy regarding EFL students' practicum has significance for any institution involved in building higher-quality programs for future-generation teachers.
Navigating Spaces, Transforming Places: A Masseyan Analysis of Gender Empowerment in Kamali
Authors: Jebeshy R Ms. Abish
Published: January 2024

Discrimination against men and women is largely made possible by the gendered division of space. It is normal for men to occupy public spaces, whereas women are restricted to domestic spaces like kitchen. As Indian society is patriarchal, it resonates with the mainstream discourse of spatial gender division. Women’s access to sports is limited by this gendered spatial setup as sporting activities are performed in so-called public spaces; traditionally, sports have been considered a “male preserve.” (Theberge, 1985) Adventure sports like skydiving, surfing, skating, mountain climbing, and mountaineering are traditionally performed by men. Hence, the mere participation of women in these activities challenges the masculine hegemony and gendered division of space that these activities entail. This paper critically examines the documentary titled, “Kamali” (2019) directed by Sasha Rainbow, which tells the inspiring story of Kamali Moorthy, a young skateboarder challenging societal norms in a small fishing village in Tamil Nadu, India. By employing Doreen Massey's space, place, and gender theory, the paper seeks to examine how the film explores the intersections of space, place, and gender within the cultural context. Doreen Massey's theoretical framework emphasizes the fluidity and relational nature of space and place, challenging fixed and essentialist perspectives.
Reimagining Connections: Exploring the Dynamics Between Gender, Nature, and Culture
Authors: Singh Shubhangi , Negi Dr. Vijay
Published: January 2024

The relationship between nature and culture has been a topic of interest for scholars and researchers across various disciplines for decades. However, the gendered aspects of this connection have not received sufficient attention until recent times. This paper aims to explore how gender plays a crucial role in shaping the interactions between human societies and the natural world. The gendered approach towards the study of nature and culture provides a critical lens to examine how gendered identities and roles shape human interactions with nature. Feminist scholars have argued that the dominant discourse surrounding nature and culture is androcentric, meaning it prioritizes male perspectives and experiences. This bias has led to a lack of understanding of how gender influences human-nature relationships, and how gendered experiences are inextricably linked to environmental issues. Through an analysis of statements and works by various authors and critics, this paper demonstrates that the gendered approach to the study of nature and culture is critical in addressing the pressing environmental issues we face today. It highlights the importance of recognizing the diverse ways in which gender shapes human interactions with the environment, and how the intersection of gender, nature, and culture is essential for creating sustainable and just societies.
Making Use of Prepositions: An Academic Proposal to Strengthen Writing Skills in First Level Students of English at the Universidad Técnica del Norte of Ibarra, Ecuador
Authors: Congo Rubén , Congo Cervantes Marlen Mishel , Congo Cervantes Dillan Steaven
Published: January 2024

This research-based article shows strengths and weaknesses that first level students of English at the Universidad Técnica del Norte of Ibarra-Ecuador have on the uses, functions and meaning of English prepositions. Prepositions, as part of the grammar system, can occur everywhere in the process of writing, and there are not many rules to help beginner students to use them correctly. It is difficult for students to learn to use prepositions all on their own; even after a lot of work and effort to achieve a high English proficiency level, students of English still struggle with prepositions. Thus, the main purpose of this work was to describe and explain why beginner students of English make mistakes when using prepositions in writing, and then contribute to the correct use of prepositions in English to strengthen not only Speaking but Writing skills.  The findings showed that there were some mistakes that beginner students committed at the moment of using prepositions when writing; the main errors encountered have relation with the following phenomena: i) Language transfer or interference from the mother tongue, ii) Transfer of training, and iii) Overgeneralization of target language rules. Therefore, this article indicates that guiding students in the study of prepositions is essential before fossilization occurs; it also motivates teachers to supplement their classes with refreshing activities and exercises that will give learners exposure to target writing since beginners.
Da Cultura da Inveja à Cultura da Dignidade
Authors: Lima Vitor Augusto de Oliveira , Fazanaro Vieira Sérgio Eduardo
Published: January 2024

O objetivo do presente artigo é investigar como a cultura atual apresenta-se como uma cultura da inveja e como uma cultura da dignidade a contrapõe, a qual se revela como um caminho para a paz social. Para tanto, será abordada a antropologia católica a fim de explicar a noção de Pecado Original e suas consequências como uma realidade inerente a todo ser humano. Uma dessas consequências é o pecado capital da inveja, o qual será tratado a nível pessoal e social. A partir disso, será construída uma análise e uma crítica à cultura atual, a qual, perdendo sua raiz metafísica e ética, possibilita que a inveja assuma para si o papel transcendental de princípio orientador da cultura, o qual norteará o agir da sociedade, causando, assim, uma cultura da inveja, sobretudo com suas duas faces: a eterna competição e o isolamento social. Em seguida, é apresentada a cultura da dignidade, a qual se fundamenta nos princípios metafísicos da Filiação Divina e da Fraternidade Universal. Por fim, tem-se a conclusão da cultura da dignidade como caminho para a paz social: uma cultura enraizada na raiz da inveja frutifica guerras e divisões, ao passo que uma cultura enraizada na dignidade frutifica a paz.
Samkennsla tveggja námskeiða í staðlotu í leikskólafræðum
Authors: Hreiðarsdóttir Anna Elísa , Mörk Svava Björg
Published: January 2024

Í greininni er fjallað um þróunarverkefni í háskólanámi þar sem fléttað var saman kennslu í tveimur námskeiðum í staðlotu. Námskeiðin tvö fjalla um kenningar um leik í leikskólakennslu og sköpun í leikskólastarfi og áherslan var á heilbrigði og velferð í öllum þáttum verkefna. Kennsluaðferðin sem beitt var í lotunni er leitar- og spurningamiðuð (e. inquiry-based learning, IBL), byggð á aðferð Susan Stacey (2019) og er sérsniðin að börnum að leikskólaaldri. Áhersla var lögð á markvissa ígrundun nema í gegnum vinnuna við verkefnin, fyrst í gegnum vinnu með sjálfsmynd og tilfinningar en síðar með því að máta við kenningar um sköpun (Malaguzzi, 1993;. Rinaldi, 2021; Vecchi, 2010) og kenningar um leik og leikumhverfi (Bandura, 1997; Bronfenbrenner, 1979). Gagna var aflað frá nemendum í formi verkefna þeirra, mati á hvernig til tókst og spurningakönnunum, en einnig með sameiginlegri ígrundun háskólakennaranna tveggja sem skrifuðu dagbækur, tóku vettvangsnótur og ljósmyndir. Niðurstöður sýna að aðferðin (IBL) skilaði árangri, nemar kunnu vel að meta áskorunina sem í vinnunni fólst og lærdóminn sem þeir tóku með sér úr staðlotunni. Kennsluaðferðin opnaði augu nema fyrir því hvernig sköpun tengist leik og hvernig margt í starfi leikskóla á rætur í kenningunum sem unnið var með en fram að þessu hafði nemum þótt erfitt að tengja þetta tvennt saman. Dregin er sú ályktun að samþætting verkefna í staðlotu hafi skilað árangri fyrir nema. Heilbrigði og velferð sem áhersla í verkefnum virkaði vel og var notadrjúg leið til að samþætta verkefnin í staðlotunni, ekki síst í að auka hæfni þeirra til að tengja fræði við starfið sem fram fer á vettvangi.
Caracterización de un Sistema Constructivo de Bajo Impacto Ambiental para viviendas destinadas a poblaciones vulnerables
Authors:   , Pérez Pérez Alma Luisa
Published: January 2024

This work aims to present the benefits and the decision to choose a Low Environmental Impact Construction System for Housing for Vulnerable Populations, as the first option in housing construction, generally speaking in Mexico. In particular, this work was developed in the specific case study, in the Xochimilco Mayor's Office, in the town of Santa Cruz Acalpixca, where various studies of the most suitable land were carried out, as well as various types of tests, to know the properties of the land and thus be able to develop with this research study of the elements the construction process of a House of 67.24 m₂, which is being planned. At the same time, the pertinent studies were carried out, which show that the house is safe and its habitability is guaranteed, to execute the construction of this project. During the construction projects of conventional Construction Systems, large investment processes are made in obtaining the materials that provide the necessary characteristics of resistance and support for the building structures. In turn, obtaining these materials is the activity that can generate the greatest number of adverse impacts on the environment and on people's quality of life. For this reason, one of the principles of sustainable construction is the implementation of environmentally friendly materials, with a long useful life and that require less energy consumption for their handling than is necessary for the handling of conventional materials. Derived from this document we have as a first, the contribution of the benefits of sustainable construction, compared to traditional construction that has been implemented in today's society. This document will focus on the selection of the construction system with its materials and the costs related to making use of them, the impacts caused in each of the stages of the project and the cost-benefit generated by traditional construction and the application of technology. sustainability in it.
Natural products in neuroprotective therapies: Experimental and cheminformatics approaches to manage neurological disorders
Authors: Rahman Md. Mominur , Hossain Md. Abid , Rifat Kajima , Maeesa Saila Kabir , Rahman A. M. Abu Sayem , Mim Mahamuda Akter , Sultana Nasrin , Sobuj Dipongkar Ray , Tamanna Israt Jahan , Islam Md. Rezaul , Sultana Sharifa , Sultana Arifa , Sharma Rohit , Singla Rajeev K.
Published: January 2024

Neurological disorders (NDs) such as Alzheimer’s disease (AD), Parkinson’s disease (PD), epilepsy, despondency, and dementia have been evidenced as a rising concern among diverse geographical regions. Brain-related diseases are currently the main concern because they increase mortality and morbidity in the elderly. Regardless of the continual efforts by modern scientists to develop a promising pharmacological or surgical management, the outcome has not been satisfactory. Also, due to synthetic drugs’ associated side effects, scientists have taken the initiative to consider using natural compounds as an alternative. Hence, they obtain pretty effective results by using natural compounds. Natural ingredients are synthesized from a variety of plant and animal sources. These natural ingredients cure brain diseases through a variety of mechanisms. For effective medication advancement, the molecules must go through preliminary clinical systems that require some investment and significant speculation. In this situation, cheminformatics is fundamental in diminishing time and venture. Cheminformatics methods play a significant role in these issues, including 3-dimensional quantitative structure-activity relationship 3D-(QSAR), virtual screening, docking, molecular dynamic studies, and quantum chemical studies. The vital purpose of this study is to disclose different types of NDs and the neuroprotective effect of several natural products for experimental and cheminformatics-based therapy. Natural products like green tea, flavonoids, and ginseng are discussed as effective neuroprotective products. However, more investigation is expected to comprehend the better utilization of regular items in future exploratory and cheminformatics-based treatment for NDs.
Proposed Development of NTRU Public Key Encryption
Authors: SAYYID MARWAH AEARABY
Published: January 2024

The 1996 proposal by Hoffstein, Pfeiffer, and Silverman for the NTRU public key encryption system provides a quick and useful substitute for factorization- or discrete logarithm-based classical programs. It rovides approximate security against quantum computing assaults and earoptimal asymptotic efficiency, in contrast to these latter approaches. The security analysis of the system involves examining naturally occurring computational and statistical challenges that are defined on finite polynomial rings. Current advancements in the broader field of latticebased cryptography, include security studies and applications of NTRU and its variations. These advancements include the creation of multilinear.
Function of the S1P pathway in hypoxia-induced cardiovascular failure
Authors: Zhou Fangping , Tang Weihong
Published: January 2024

Background: Vascular failure (VF) and heart failure (HF) are extremely harmful and are the primary causes of hypoxia. Our previous results have shown that the sphingosine-1-phosphate (S1P) pathway was involved in regulating intermittent hypoxia–induced vascular defection, but the clinical role and molecular mechanism of the S1P pathway remain unclear.

Methods: Normalized relative expression values and differentially expressed genes were downloaded in GSE145221 from the Gene Expression Omnibus dataset. WGCNA was used to construct a gene co-expression network. The Spearman correlation matrix was used to identify the top 500 highly correlated genes with the S1P pathway genes. R package clusterProfiler was used to perform Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses on the WGCNA modules. Homer software was utilized to identify regulatory motifs in the promoter and gene body regions of S1P pathway genes. An intermittent hypoxic injury cell model was induced by chronic intermittent hypoxia (CIH). ROS and TUNEL staining and Western blot were used to detect cell apoptosis and reactive oxygen species.

Results: The transcriptional regulatory regions of S1P pathway genes were enriched with hypoxia-inducible factor 1-alpha, which indicated the close connection between the S1P pathway and the CIH process. In vitro, we confirmed that the endothelial cell apoptosis induced by CIH could be reversed by exogenous addition of S1P.

Conclusions: This study elucidated the mechanism of the S1P pathway in regulating cardiovascular injury caused by CIH and provided a new strategy for early intervention in people with cardiovascular dysfunction induced by hypoxia.
Predictive value of expression of the CXCR4/Akt signaling pathway in the peripheral blood for brain glioma
Authors: Zou Xueli
Published: January 2024

Background: The aim of this study was to investigate the activation of the C-X-C chemokine receptor type 4 (CXCR4)/Akt signaling pathway in the peripheral blood of individuals diagnosed with brain glioma and assess its potential as a predictive marker.

Methods: A study was carried out on 120 patients diagnosed with brain glioma who were admitted between September 2015 and October 2016 (referred to as the brain glioma group). Additionally, a control group consisting of 100 healthy individuals who underwent physical examinations during the same time frame was included. According to the postoperative follow-up results, the patients with brain glioma were divided into death subgroup (n=30) and survival subgroup (n=85). Reverse transcription-polymerase chain reaction was used to identify the presence of molecules associated with the CXCR4/Akt signaling pathway in the peripheral blood samples.

Results: The expressions of the CXCR4/Akt signaling pathway-related molecules differed significantly among tumor World Health Organization (WHO) grades and clinical outcome subgroups (P<0.05). The CXCR4 expression showed a significant correlation with the WHO grade of the tumor, Akt mRNA, E-cadherin, N-cadherin, and vimentin (P<0.05). The prognosis was significantly influenced by the elevated levels of CXCR4/Akt, tumor WHO grade, E-cadherin, N-cadherin, and vimentin, which acted as autonomous risk factors. The prognostic prediction accuracy of CXCR4/Akt was 90.48% for sensitivity and 94.87% for specificity, with a significant area under the receiver operating characteristic curve of 0.908 (P<0.05). Patients with high levels of CXCR4/Akt signaling pathway-related molecules had a considerably lower 5-year survival rate compared to those with low levels (21.08% vs. 46.37%, P<0.05).

Conclusions: The expression of the CXCR4/Akt signaling pathway is significantly up-regulated in the peripheral blood of patients with brain glioma and is closely related to malignant tumor transformation.
Investment Risk – Bibliometric Analysis at the Level of EU States
Authors: Bratiloveanu Alexandra , Ignat Nicoleta Daniela , Croitoru Ionuț Marius
Published: January 2024

This research examines how investment risk is treated within a selection of 667 articles from the Web of Science database, made by applying keywords and filters, within a bibliometric analysis. The keywords by which the selection was made were investment risk, and the specific filters were: the authors’ countries of origin, EU states, and the articles to be published in the period 2019-2023 in order to identify current risks associated with investments. To ensure that the aspects analyzed are from the economic field, we chose the fields of economics, management, and business in the Web of Science categories. In Citation Topics Meso, we chose the subfields of economics and management.

The authors’ territorial distribution and affiliation were analyzed using the Web of Science and VOS viewer software functions. The analysis of the density of words and phrases associated with investment risk was substantiated with the help of Word Cloud software, Word Art, and VOSviewer software, applying the co-occurrence filter. The results generated after filtering reveal 5 clusters with a total of 87 words that are associated with investment risk, appearing at least 10 times. In addition, besides the words risk and investments, other terms with strong links in the selection were performance, impact, determinants, market, growth, and liquidity. The associations resulting from our research can form the basis of other research regarding the decision to invest and the classification of the investments or the risks to which the investment process is subject.
Forensic Accounting, a Tool for Detecting and Preventing the Economic Fraud
Authors: Anghel Gabriela , Poenaru Cristina-Elena
Published: January 2024

Economic crime is an increasing threat to the economic development of a state. While the legislative system tries to create tools to detect and prevent fraud, criminals continue to look for ways to commit and benefit from economic crimes, including fraud, money laundering, sanctions avoidance and corruption. Forensic accounting applies scientific techniques and accounting principles to detect fraudulent activities. Due to technological progress, corporate scams have increased enormously, and therefore, the need for forensic accountants has increased.

Professionals specializing in this type of accounting don’t just examine financial statements: they take a holistic approach, incorporating statistical analysis, big data and machine learning, interviews, and physical observation to arrive at the truth – which is just as crucial to due diligence as it is to criminal cases.
Diagnostic Approach and Management of Clostridium difficile Infection
Authors: Hosea Fransiscus Nikodemus , Fauzi Achmad
Published: January 2024

Clostridium difficile infection (CDI) was first viewed as a nosocomial infection as it is associated with antibiotics administration. But since antibiotics are more frequently to be prescribed in the community setting, clinicians should investigate the probability of all antibiotics-associated diarrhea as CDI.Diagnostic of CDI should be conducted cautiously as the manifestation of CDI varies from asymptomatic to fatal consequences and is associated with morbidity, mortality, recurrence risk, outbreak possibility, and low quality of life. Management of this infection should include infection prevention and control, stopping the offending antibiotics, and administration of specific antimicrobials.Clinicians should also recognize the risk of recurrence and the higher probability of less efficacious specific antimicrobials in each episode of recurrence.
Prevalence and Association of Helicobacter pylori Infection in Gastric Disease at Dr. Cipto Mangunkusumo General National Hospital 2010–2021
Authors: Mustikarani Dewi
Published: January 2024

Background: Several studies showed contrasting associations between Helicobacter pylori infection and organic gastric disorders. We aim to determine the association between H. pylori infection and gastroesophageal reflux disease (GERD), gastric polyp, and gastric cancer in an Indonesian national referral hospital.Method: Data collected from patients referred to Cipto Mangunkusumo General National Hospital, Jakarta, Indonesia, from 2010 to 2021, with complete H. pylori test and endoscopy from electronic medical record. Chi-square analysis and logistic regression were performed to determine the association with a significant p-value of 0.05.Results: Three hundred and fourteen consecutive patients were enrolled, with a median age of 51.0 (16‒85), and 131 (41.7%) of them were males. The prevalence of H. pylori infection in organic gastric disease was 7.6% (n = 24) with 0.3% (n = 1) of them has gastric cancer, 3.2% gastric polyp (n = 10), and 4.1% (n = 13) GERD. A proven association between H. pylori infection and GERD was observed (RR = 26.42; 95% CI: 76.12‒114.05; p = 0.000) and esophagitis (RR = 2.44; 95% CI: 1.71‒3.49; p = 0.000). However, no significant association was found between H. pylori infection and gastric cancer (RR = 4.07; 95% CI: 0.26‒64.09; p = 0.28), and gastric polyp (RR = 1.16; 95% CI: 0.61‒2.22; p = 0.65).Conclusion: Our study suggested association of H. pylori infection in GERD and oesophagitis patients. Insignificant association was observed between H. pylori infection and gastric cancer, and gastric polyp.Keywords: Helicobacter pylori, esophagitis, GERD, gastric polyps, gastric cancer