bluuebunny/crossref_metadata_2025 huggingface dataset:
MDGF-MCEC: a multi-view dual attention embedding model with cooperative ensemble learning for CircRNA-disease association prediction
Authors: Wu Qunzhuo , Deng Zhaohong , Pan Xiaoyong , Shen Hong-Bin , Choi Kup-Sze , Wang Shitong , Wu Jing , Yu Dong-Jun
Published: July 2022

Circular RNA (circRNA) is closely involved in physiological and pathological processes of many diseases. Discovering the associations between circRNAs and diseases is of great significance. Due to the high-cost to verify the circRNA-disease associations by wet-lab experiments, computational approaches for predicting the associations become a promising research direction. In this paper, we propose a method, MDGF-MCEC, based on multi-view dual attention graph convolution network (GCN) with cooperative ensemble learning to predict circRNA-disease associations. First, MDGF-MCEC constructs two disease relation graphs and two circRNA relation graphs based on different similarities. Then, the relation graphs are fed into a multi-view GCN for representation learning. In order to learn high discriminative features, a dual-attention mechanism is introduced to adjust the contribution weights, at both channel level and spatial level, of different features. Based on the learned embedding features of diseases and circRNAs, nine different feature combinations between diseases and circRNAs are treated as new multi-view data. Finally, we construct a multi-view cooperative ensemble classifier to predict the associations between circRNAs and diseases. Experiments conducted on the CircR2Disease database demonstrate that the proposed MDGF-MCEC model achieves a high area under curve of 0.9744 and outperforms the state-of-the-art methods. Promising results are also obtained from experiments on the circ2Disease and circRNADisease databases. Furthermore, the predicted associated circRNAs for hepatocellular carcinoma and gastric cancer are supported by the literature. The code and dataset of this study are available at https://github.com/ABard0/MDGF-MCEC.
Decreased expression of GRIM-19 induces autophagy through the AMPK/ULK1 signaling pathway during adenomyosis
Authors: Huang YuFei , Zhao Yue , Liu HaoRan , Yang Yang , Cheng LaiYang , Deng XiaoHui , Chao Lan
Published: July 2022

The processes underlying adenomyosis are similar to those of tumor metastasis, and it is defined as progressive invasion by the endometrium and the subsequent creation of ectopic lesions. GRIM-19 regulates cell death via the mitochondrial respiratory chain. Stress following oxygen deprivation can induce tumor cell autophagy, leading to cell invasion and migration. Here, we revealed that GRIM-19 negatively regulates autophagy, and, at least in adenomyosis, decreased expression of GRIM-19 is accompanied by an increased level of autophagy and 5′-adenosine monophosphate-activated protein kinase-Unc-51 like autophagy activating kinase 1 (AMPK-ULK1) activation. Upregulation of GRIM-19 expression in human primary endometrial cells and ISHIKAWA cells inhibits autophagy via the AMPK-ULK1 pathway and helps control cell invasion and migration. In addition, we also identified increased expression of AMPK and ULK1, and higher levels of autophagy in the uterine tissues of GRIM-19+/− mice. Importantly, the function of the GRIM-19-AMPK-ULK1 axis in regulating autophagy in adenomyosis is similar to that of tumor tissues, which may help elucidate the regulation of adenomyosis tumor-like behavior, and is expected to help identify novel targets for the diagnosis and treatment of adenomyosis.
Genomic testing in premature ovarian insufficiency: proceed with caution
Authors: Tucker Elena J , Tan Tiong Y , Stark Zornitza , Sinclair Andrew H
Published: July 2022

Genomic testing has the potential to transform outcomes for women with infertility conditions, such as premature ovarian insufficiency (POI), with growing calls for widespread diagnostic use. The current research literature, however, often uses poor variant curation leading to inflated diagnostic claims and fails to address the complexities of genomic testing for this condition. Without careful execution of the transition from research to the clinic, there is danger of inaccurate diagnoses and poor appreciation of broader implications of testing. This Forum outlines the benefits of genomic testing for POI and raises often overlooked concerns.
Chromatographic Analysis of Aqueous Humor of Bupivacaine in Different Administration Approaches
Authors: Dinçel Aysun , Kızıltunç Pınar Bingöl , Atilla Huban , Onur Feyyaz , Demirel Sibel
Published: July 2022

Different administration approaches were investigated for the selection of bupivacaine administration type and a sensitive high-performance liquid chromatographic (HPLC) method has been developed. Developed method was validated and applied for the determination of bupivacaine in rabbit aqueous humor. The separation was achieved using a XTerra, C8 (250 × 8 mm i.d., particle size 5 μm) analytical column with a mobile phase consisted of acetonitrile and sodium dihydrogen phosphate (pH = 3.0, 20 mM; 30:70, v/v). Bupivacaine detection was performed by Diode Array detector (DAD) at 220 nm. The retention times for bupivacaine is 15.886 min. HPLC-DAD method was linear in the range of 75–4000 ng/mL. The limit of detection was 25 ng/mL and the limit of quantification of bupivacaine was found to be 75 ng/mL (relative standard deviation, RSD ≤ 15%, n = 6). In intra-day and inter-day precision and accuracy analysis, the RSD was found to be in the range of 0.96 and 7.98%, the bias values were 0.64 and 3.33%. Method was carried out for three different type of bupivacaine application because of the investigation of effective drug administration. Twenty aqueous humor samples were in the range of 0.642 and 5.124 μg/mL.
Handling uncertainties in forest information: the hierarchical forest planning process and its use of information at large forest companies
Authors: Ulvdal Patrik , Öhman Karin , Eriksson Ljusk Ola , Wästerlund Dianne Staal , Lämås Tomas
Published: July 2022

This qualitative study aimed to map what information is used in the forest planning process at large forest-owning companies, how it is used, its level of uncertainty and currently employed strategies to handle forest information uncertainty. An additional aim was to assess the status of the paradigm of the forest planning hierarchy in forestry. We used data from semi-structured interviews with representatives of six large forest-owning companies in Sweden, representing 30 per cent of the productive forest land in the country. Our results show that the forest planning process is a hierarchical system of decisions where the information used in the different planning stages is of varying quality and that the traditional hierarchical planning paradigm still plays a vital role in forestry. The most central source of information in the whole forest-planning process is the forest stand database (forest inventory). This includes uncertain information from various sources, including subjective field measurements and aerial image interpretation. However, the use of remote sensing estimates to feed the databases is increasing, which will probably improve the overall quality. Another important finding is that forest companies tend not to use decision support systems or optimization models to solve planning problems outside the scope of strategic planning; thus, most planning is done manually, e.g. in a geographic information system (GIS) environment. Apart from the hierarchical division of the planning process itself, we identified six main strategies that the companies use to control information uncertainty, namely locking the future by making a decision, utilizing a surplus of available harvests, updating information before a decision is made, replanning when the plan is found to be infeasible, planning by looking back and ignoring the uncertainty, either intentionally or unintentionally. The results from this study increase our understanding of contemporary forest-planning practices and will be helpful in the development of decision support systems and methods for information collection.
Urbanization and Cognitive Function Among Middle-Aged and Old Adults in China
Authors: Pan Yao , Wu Xiaofang , Liu Yan , Li Zhuo , Yang Yingkai , Luo Yanan
Published: July 2022

Objectives

Our study examined the effect of urbanization on cognitive function and its possible pathways among Chinese middle-aged and older adults independent of the influence of health-selective migration.

Methods

Using data from the China Health and Retirement Longitudinal Study, we compared cognitive function among three groups (urbanized-rural residents, rural nonmigrants, and urban nonmigrants). Logistic regression and structural equation models were applied to explore the impact of urbanization on cognitive function and the potential mechanisms.

Results

Compared with the urbanized-rural group, urban nonmigrants had better cognitive function, with a significant coefficient of 1.56 (95% CI: 1.22, 1.89) for global cognition scores and 0.37 (95% CI: 0.22, 0.53) for episodic memory scores. The rural nonmigrants had the worst cognitive function (β = −0.79, 95% CI: −1.04, −0.55) and lower scores of mental intactness (β = −0.65, 95% CI: −0.84, −0.57) and episodic memory (β = −0.14, 95% CI: −0.26, −0.03). The association between urbanization and cognitive function was mainly mediated by income and living conditions among middle-aged and older adults.

Discussion

Rural people who experienced planned urbanization in China had higher cognitive scores than rural non-migrants. Urbanization could thus have a beneficial and cumulative effect on cognitive function. Improvements in living conditions and changes in income are the main drivers behind the relationship. However, urbanization could compensate for the negative impact on cognitive function from disadvantaged early-life conditions, but it cannot completely eliminate the gap between urbanized-rural people and urban nonmigrants.
A Systematic Review of Subjective Cognitive Characteristics Predictive of Longitudinal Outcomes in Older Adults
Authors: Earl Robertson Frank , Jacova Claudia
Published: July 2022

Background and Objectives

Subjective cognitive decline (SCD) is a common experience of self-perceived decline without objective cognitive impairment among older adults. SCD has been conceptualized as very early Alzheimer’s disease (AD), but the specific SCD features predictive of clinical or cognitive decline remain unclear. This systematic review is the first to characterize specific SCD features and their relation to longitudinal outcomes.

Research Design and Methods

Multiple electronic databases were searched from inception until August 2021 for longitudinal studies of adults aged ≥50 (mean ≥60) and free of dementia, with baseline SCD measurement and clinical or cognitive follow-up. Studies were screened for inclusion criteria and assessed for risk of bias using weight-of-evidence ratings.

Results

Five hundred and seventy potentially relevant studies were identified, and 52 studies were evaluated for eligibility after initial screening. Thirty-three studies with medium to high weight-of-evidence ratings were included, and results were narratively synthesized. Measurement methods varied substantially across studies: the majority (n = 27) assessed SCD symptom types and intensity, and consistently reported that a higher symptom burden increased the risk for mild cognitive impairment (MCI) and dementia. The evidence was less compelling for cognitive outcomes. A handful of studies (n = 5) suggested a predictive role for SCD symptom consistency and informant corroboration.

Discussion and Implications

SCD symptom intensity emerged from our review as the most reliable predictor of future clinical outcomes. Combinations of SCD-Plus symptoms also had predictive utility. No single symptom was uniquely prognostic. Our findings support the quantitative evaluation of SCD symptoms in the assessment of risk for progression to MCI or dementia.
Tsunamis in Lingding Bay, China, caused by the 2022 Tonga volcanic eruption
Authors: Wang Yuchen , Wang Peitao , Kong Hoiio , Wong Chan-Seng
Published: July 2022

The Hunga Tonga-Hunga Ha'apai volcano eruption resulted in propagation of tsunamis globally. Atmospheric pressure disturbances and tsunamis were recorded in Lingding Bay, China, situated more than 9000 km from the volcano. We studied the features of tsunamis in Lingding Bay and its surrounding areas by using records from tide gauges and meteorological stations. Lamb waves were observed in the bay approximately 8, 44 and 80 hr after the volcanic eruption. The first and second tsunami waves arrived approximately 11 and 45–47 hr following the eruption, respectively, indicating consistency with the arrival time of Lamb waves. In addition, wavelet and Fourier analyses were applied to the sea level records to investigate the frequency characteristics. The ratio of the tsunami spectra to the background spectra for two tsunami waves was calculated as the source spectra. The source spectra of two tsunami waves were mostly of the same shape, with dominant periods of ∼17 and ∼46 min. Our results provide information for theoretical investigation of the Tonga tsunami event. More efforts should be devoted to relevant research on the generating mechanism and early warning of tsunamis from non-seismic origins.
D2/D3 Receptor Agonism: Paving the Way for a New Therapeutic Target for Taste Disorders in Parkinson’s Disease and Other Conditions?
Authors: Mantovani Elisa , Tamburin Stefano
Published: July 2022

Chemosensory (i.e., olfaction and taste) dysfunction is common in neurodegenerative (e.g., Parkinson’s disease, Alzheimer’s disease, and dementia), psychiatric (e.g., depression, bipolar disorders, other conditions), and postinfectious (i.e., long COVID) diseases and in the elderly. Despite its impact on patients’ quality of life, no established treatment for taste disorders exists so far. A recent report on the effect of pramipexole, a D2/D3 agonist, on taste performance in healthy participants provides support for a new potential therapeutic target for taste dysfunction to be tested in future randomized, placebo-controlled, clinical trials across several populations reporting gustatory symptoms.
Trends in strong opioid prescription for cancer patients in Japan from 2010 to 2019: an analysis with large medical claims data
Authors: Takahashi Richi , Miyashita Mitsunori , Murakami Yoshitaka , OBA Mari S
Published: July 2022

Background

Consumption of opioids, essential drugs for pain relief, has seen rapid growth worldwide. In Japan, where total opioid consumption still remains low among developed countries, little is known about trends in the clinical patterns of opioids in terminally ill cancer patients.

Methods

Patients who died of cancer from 2010 to 2019 were included in this study. Morphine, oxycodone, fentanyl, tapentadol, methadone and hydromorphone were examined as opioids for cancer pain. We calculated the prevalence of prescribed opioids prior to death by year and age group and the average opioid dose 30 days before death.

Results

The total number of patients was 221 598. We found that the prescription prevalence of opioids increased from 60.8 to 65.9% (5.1%). Morphine was most prescribed in 2010 but had decreased prevalence (−9.0%) during the 10-year period. Oxycodone had the highest increase in prescription prevalence (13.7%), and fentanyl prevalence decreased (−4.9%). In the subgroup comparison, the prescription prevalence of opioids in the elderly was lower than that in the younger group; however, the increasing trend in the elderly was greater than that in the younger group. The percentage of patients prescribed low-dose opioids (<60 mg/day) during the 30 days before death increased by 4.9% and was the highest throughout the study period.

Conclusion

The prevalence of opioid prescriptions for terminally ill cancer patients has increased from 2010 to 2019 in Japan. The opioid-specific trends were similar to the global trend but differed by palliative care specialty.
Prevention of delirium with agitation by yokukansan in older adults after cancer surgery
Authors: Sadahiro Ryoichi , Wada Saho , Matsuoka Yutaka J , Uchitomi Yosuke , Yamaguchi Takuhiro , Sato Tetsufumi , Esaki Minoru , Yoshimoto Seiichi , Daiko Hiroyuki , Kanemitsu Yukihide , Kawai Akira , Kato Tomoyasu , Fujimoto Hiroyuki , Uezono Yasuhito , Shimizu Ken , Matsuoka Hiromichi
Published: July 2022

Objective

Preventing postoperative delirium with agitation is vital in the older population. We examined the preventive effect of yokukansan on postoperative delirium with agitation in older adult patients undergoing highly invasive cancer resection.

Methods

We performed a secondary per-protocol analysis of 149 patients’ data from a previous clinical trial. Patients underwent scheduled yokukansan or placebo intervention 4–8 days presurgery and delirium assessment postoperatively. Delirium with agitation in patients aged ≥75 years was assessed using the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, and the Japanese version of the Delirium Rating Scale-Revised-98. We assessed odds ratios for yokukansan (TJ-54) compared with placebo for the manifestation of postoperative delirium with agitation across patients of all ages (n = 149) and those aged ≥65 years (n = 82) and ≥ 75 years (n = 21) using logistic regression.

Results

Delirium with agitation manifested in 3/14 and 5/7 patients in the TJ-54 and placebo groups, respectively, among those aged ≥75 years. The odds ratio for yokukansan vs. placebo was 0.11 (95% confidence interval: 0.01–0.87). An age and TJ-54 interaction effect was detected in patients with delirium with agitation. No intergroup differences were observed in patients aged ≥65 years or across all ages for delirium with agitation.

Conclusions

This is the first study investigating the preventive effect of yokukansan on postoperative delirium with agitation in older adults. Yokukansan may alleviate workforce burdens in older adults caused by postoperative delirium with agitation following highly invasive cancer resection.
Orchid fruiting success is unrelated to surrounding floral resources in South Australian plant communities
Authors: Martín-Forés Irene , Bywaters Samantha L , Sparrow Ben , Guerin Greg R
Published: July 2022

To maintain recruitment in orchid populations in an ecosystem setting, we must understand how surrounding floral resources affect fruiting success. We studied fruiting success in two endemic Australian species, Diuris pardina and Glossodia major, in relation to surrounding floral resources. Diuris pardina has a visually deceptive pollination strategy via mimicry of pea flowers, attracting pollinators associated with co-flowering plants of Pultenaea. Glossodia major displays dummy anthers and has a more generalist pollination strategy. We expected fruiting success of both species to positively correlate to conspecific and heterospecific floral density because orchid pollination should be enhanced by the attraction of higher densities of native bees. We expected fruiting success of D. pardina to positively correlate with abundance of Pultenaea flowers. Surveying 18 plots in South Australia, we counted species, individuals and flowers of conspecifics and heterospecifics and returned to count flowers that set fruit. We conducted Pearson correlations between fruiting success and density of conspecific flowers, richness, abundance and Shannon index of surrounding floral resources and floral abundance of individual species. Fruiting success was correlated with conspecific floral density for D. pardina but not G. major. No relationship was found between fruiting success and heterospecific floral resources. Fruiting success of D. pardina was not correlated with abundance of Pultenaea; instead it was positively correlated with the invasive species Lavandula stoechas.
Molecular tracers of planet formation in the atmospheres of hot Jupiters
Authors: Hobbs Richard , Shorttle Oliver , Madhusudhan Nikku
Published: July 2022

The atmospheric chemical composition of a hot Jupiter can lead to insights into where in its natal protoplanetary disc it formed and its subsequent migration pathway. We use a 1D chemical kinetics code to compute a suite of models across a range of elemental abundances to investigate the resultant abundances of key molecules in hot Jupiter atmospheres. Our parameter sweep spans metallicities between 0.1x and 10x solar values for the C/H, O/H, and N/H ratios, and equilibrium temperatures of 1000 and 2000 K. We link this parameter sweep to the formation and migration models from previous works to predict connections between the atmospheric molecular abundances and formation pathways, for the molecules H2O, CO, CH4, CO2, HCN, and NH3. We investigate atmospheric H2O abundances in eight hot Jupiters reported in the literature. All eight planets fall within our predicted ranges for various formation models; however, six of them are degenerate between multiple models and hence require additional molecular detections for constraining their formation histories. The other two planets, HD 189733 b and HD 209458 b, have water abundances that fall within ranges expected from planets that formed beyond the CO2 snowline. Finally, we investigate the detections of H2O, CO, CH4, CO2, HCN, and NH3 in the atmosphere of HD 209458 b and find that, within the framework of our model, the abundances of these molecules best match with a planet that formed between the CO2 and CO snowlines and then underwent disc-free migration to reach its current location.
Implementation of dust particles in three-dimensional magnetohydrodynamics simulation: dust dynamics in a collapsing cloud core
Authors: Koga Shunta , Kawasaki Yoshihiro , Machida Masahiro N
Published: July 2022

The aim of this study is to examine dust dynamics on a large scale and investigate the coupling of dust with gas fluid in the star formation process. We propose a method for calculating the dust trajectory in a gravitationally collapsing cloud, where the dust grains are treated as Lagrangian particles and are assumed to be neutral. We perform the dust trajectory calculations in combination with non-ideal magnetohydrodynamics simulation. Our simulation shows that dust particles with a size of $\le 10\, {\rm \mu m}$ are coupled with gas in a star-forming cloud core. We investigate the time evolution of the dust-to-gas mass ratio and the Stokes number, which is defined as the stopping time normalized by the freefall time-scale, and show that large dust grains ($\gtrsim 100\, {\rm \mu m}$) have a large Stokes number (close to unity) and tend to concentrate in the central region (i.e. protostar and rotationally supported disc) faster than do small grains ($\lesssim 10\, {\rm \mu m}$). Thus, large grains significantly increase the dust-to-gas mass ratio around and inside the disc. We also confirm that the dust trajectory calculations, which trace the physical quantities of each dust particle, reproduce previously reported results obtained using the Eulerian approach.
The effects of non-linearities on tidal flows in the convective envelopes of rotating stars and planets in exoplanetary systems
Authors: Astoul A , Barker A J
Published: July 2022

In close exoplanetary systems, tidal interactions drive orbital and spin evolution of planets and stars over long time-scales. Tidally forced inertial waves (restored by the Coriolis acceleration) in the convective envelopes of low-mass stars and giant gaseous planets contribute greatly to the tidal dissipation when they are excited and subsequently damped (e.g. through viscous friction), especially early in the life of a system. These waves are known to be subject to non-linear effects, including triggering differential rotation in the form of zonal flows. In this study, we use a realistic tidal body forcing to excite inertial waves through the residual action of the equilibrium tide in the momentum equation for the waves. By performing 3D non-linear hydrodynamical simulations in adiabatic and incompressible convective shells, we investigate how the addition of non-linear terms affects the tidal flow properties, and the energy and angular momentum redistribution. In particular, we identify and justify the removal of terms responsible for unphysical angular momentum evolution observed in a previous numerical study. Within our new set-up, we observe the establishment of strong cylindrically sheared zonal flows, which modify the tidal dissipation rates from prior linear theoretical predictions. We demonstrate that the effects of this differential rotation on the waves neatly explains the discrepancies between linear and non-linear dissipation rates in many of our simulations. We also highlight the major role of both corotation resonances and parametric instabilities of inertial waves, which are observed for sufficiently high tidal forcing amplitudes or low viscosities, in affecting the tidal flow response.
Observable signatures of cosmic rays transport in Starburst Galaxies on gamma-ray and neutrino observations
Authors: Ambrosone Antonio , Chianese Marco , Fiorillo Damiano F G , Marinelli Antonio , Miele Gennaro
Published: July 2022

The gamma-ray emission from Starburst and Star-forming Galaxies (SBGs and SFGs) strongly suggests a correlation between star-forming activity and gamma-ray luminosity. However, the very nature of cosmic ray (CR) transport and the degree of their confinement within SBG cores are still open questions . We aim at probing the imprints left by CR transport on gamma-ray and neutrino observations of point-like SFGs and SBGs, looking into quantitative ways to discriminate among different transport models. We analyse the 10-yr Fermi-LAT spectral energy distributions of 13 nearby galaxies with two different CR transport models, taking into account the corresponding IR and UV observations. We also generate mock gamma-ray data to simulate the CTA performance in detecting these sources. In this way, we propose a test to discriminate between the two CR models, quantifying the statistical confidence at which one model can be preferred over the other. We point out that the current data already give a slight preference to CR models that are dominated by advection. Moreover, we show that CTA will allow us to firmly disfavour models dominated by diffusion over self-induced turbulence, compared to advection-dominated models, with Bayes factors, which can be as large as 107 for some of the SBGs. Finally, we estimate the diffuse gamma-ray and neutrino fluxes of SFGs and SBGs, showing that they can explain $25{{\,\rm per\ cent}}$ of the diffuse HESE data while remaining consistent with gamma-ray limits on non-blazar sources.
Onset of common envelope evolution during a core helium flash by rapid envelope expansion
Authors: Fainer Stanislav , Bear Ealeal , Soker Noam
Published: July 2022

We suggest that the vigorous core convection during core helium flash on the tip of the red giant branch (RGB) of low-mass stars excites waves that carry energy to the envelope and inflate it for few years to increase the number of extreme horizontal branch (EHB; sdB and sdO) stars with masses of $\simeq 0.47 \, \mathrm{M}_\odot$ with respect to canonical binary evolution. Using the open-source mesa-binary, we follow the evolution of a number of eccentric binary systems with an initial primary stellar mass of $1.6 \, \mathrm{M}_\odot$. The energy that the waves carry to the envelope leads to envelope expansion at the tip of the RGB. The inflated RGB star engulfs many secondary stars to start a CEE that otherwise would not occur. If the secondary star manages to remove most of the RGB envelope the primary evolves to become an EHB star with a mass of $\simeq 0.47 \, \mathrm{M}_\odot$. However, we expect that in most cases the secondary star does not have time to spiral-in to close orbits. It rather ends at a large orbit and leaves a massive enough envelope for the primary star to later evolve along the asymptotic giant branch and to engulf the secondary star, therefore forming a non-spherical planetary nebula.
Constraining galaxy–halo connection with high-order statistics
Authors: Zhang Hanyu , Samushia Lado , Brooks David , de la Macorra Axel , Doel Peter , Gaztañaga Enrique , Gontcho A Gontcho Satya , Honscheid Klaus , Kehoe Robert , Kisner Theodore , Meisner Aaron , Poppett Claire , Schubnell Michael , Tarle Gregory , Zhang Kai , Zou Hu
Published: July 2022

We investigate using three-point statistics in constraining the galaxy–halo connection. We show that for some galaxy samples, the constraints on the halo occupation distribution parameters are dominated by the three-point function signal (over its two-point counterpart). We demonstrate this on mock catalogues corresponding to the Luminous red galaxies (LRGs), Emission-line galaxies (ELGs), and quasars (QSOs) targeted by the Dark Energy Spectroscopic Instrument (DESI) Survey. The projected three-point function for triangle sides less up to 20 h−1 Mpc measured from a cubic Gpc of data can constrain the characteristic minimum mass of the LRGs with a preci sion of 0.46 per cent. For comparison, similar constraints from the projected two-point function are 1.55 per cent. The improvements for the ELGs and QSOs targets are more modest. In the case of the QSOs, it is caused by the high shot-noise of the sample, and in the case of the ELGs, it is caused by the range of halo masses of the host haloes. The most time-consuming part of our pipeline is the measurement of the three-point functions. We adopt a tabulation method, proposed in earlier works for the two-point function, to significantly reduce the required compute time for the three-point analysis.
V410 Puppis: A useful laboratory for early stellar evolution
Authors: Erdem Ahmet , Sürgit Derya , Özkardeş Burcu , Hadrava Petr , Rhodes Michael D , Love Tom , Blackford Mark G , Banks Timothy S , Budding Edwin
Published: July 2022

New spectrometric (HERCULES) and ground-based multicolour photometric data on the multiple star V410 Puppis are combined with satellite photometry (HIPPARCOS and TESS), as well as historic astrometric observations. Absolute parameters for V410 Pup Aab are derived: MAa = 3.15 ± 0.10, MAb = 1.83 ± 0.08 (M⊙); RAa = 2.12 ± 0.10, RAb = 1.52 ± 0.08 (R⊙); a = 6.57 ± 0.04 R⊙; TAa = 12500 ± 1000, TAb = 9070 ± 800(K), and photometric distance 350 ± 10 (pc). We report the discovery of a low-amplitude SPB variation in the light curve and also indications of an accretion structure around V410 Pup B as well as emission cores in V410 Pup C. We argue that V410 Pup is probably a young formation connected with the Vela 2 OB Association. The combined evidence allows an age in the range 7–25 Myr from comparisons with standard stellar evolution modelling.
The Impact of Hypopressive Abdominal Exercise on Linea Alba Morphology in Women Who Are Postpartum: A Short-Term Cross-Sectional Study
Authors: Arranz-Martín Beatriz , Navarro-Brazález Beatriz , Sánchez-Sánchez Beatriz , McLean Linda , Carazo-Díaz Carmen , Torres-Lacomba María
Published: July 2022

Objective

The purpose of this study was to determine the acute effect of an abdominal hypopressive exercise (AHE) on linea alba morphology among women who are primiparous and to compare this effect with that of other common abdominal exercise modalities.

Methods

A cross-sectional study of 46 women 3 months after first delivery was conducted. B-mode ultrasound imaging of the interrectus distance (IRD) and linea alba distortion was performed 2 cm below (I-point) and above (S-point) the umbilicus and at the mid-point between the umbilicus and xiphoid process (X-point). Images were recorded at rest and during an AHE performed in a supine position, a semi curl-up (SCU), an abdominal drawing-in maneuver (ADIM), and a SCU performed after an initial ADIM (ADIM+SCU).

Results

The SCU exercise narrowed the IRD at the X- and S-points. Compared with SCU, AHE and ADIM widened the IRD at the S- and X-points. No significant differences were found when comparing the IRD at rest, during AHE and during ADIM, but AHE tended to narrow I-point IRD more than ADIM but to widen S-point IRD more than ADIM+SCU. No participant showed linea alba distortion during the AHE or ADIM. When compared, SCU increased the occurrence of distortion with respect to AHE and ADIM. The isolated hypopressive posture did not change the IRD or linea alba distortion.

Conclusion

Among women who were postpartum, AHE seemed to narrow IRD below the umbilicus compared with ADIM without either of these 2 modalities generating linea alba distortion, as SCU or ADIM+SCU does. Thus, although no significant differences were found when comparing the IRD at rest and during AHE, the AHE could improve the tensile response of the linea alba without increasing the IRD.

Impact

This is believed to be the first study to describe linea alba changes during AHE in women who are postpartum. AHE and ADIM seem to show different effects on infraumbilical IRD. The lack of distortion suggests that linea alba may undergo tensile loading at all levels.
Leveraging genetic discoveries for sleep to determine causal relationships with common complex traits
Authors: Sonti Shilpa , Grant Struan F A
Published: July 2022

Sleep occurs universally and is a biological necessity for human functioning. The consequences of diminished sleep quality impact physical and physiological systems such as neurological, cardiovascular, and metabolic processes. In fact, people impacted by common complex diseases experience a wide range of sleep disturbances. It is challenging to uncover the underlying molecular mechanisms responsible for decreased sleep quality in many disease systems owing to the lack of suitable sleep biomarkers. However, the discovery of a genetic component to sleep patterns has opened a new opportunity to examine and understand the involvement of sleep in many disease states. It is now possible to use major genomic resources and technologies to uncover genetic contributions to many common diseases. Large scale prospective studies such as the genome wide association studies (GWAS) have successfully revealed many robust genetic signals associated with sleep-related traits. With the discovery of these genetic variants, a major objective of the community has been to investigate whether sleep-related traits are associated with disease pathogenesis and other health complications. Mendelian Randomization (MR) represents an analytical method that leverages genetic loci as proxy indicators to establish causal effect between sleep traits and disease outcomes. Given such variants are randomly inherited at birth, confounding bias is eliminated with MR analysis, thus demonstrating evidence of causal relationships that can be used for drug development and to prioritize clinical trials. In this review, we outline the results of MR analyses performed to date on sleep traits in relation to a multitude of common complex diseases.
Leadership Development to Advance Health Equity: An Equity-Centered Leadership Framework
Authors: Corbie Giselle , Brandert Kathleen , Fernandez Claudia S.P. , Noble Cheryl C.
Published: July 2022

Enduring questions about equity are front and center at this watershed moment in health care and public health. Inequities that became evident in the COVID-19 pandemic in 2020 have highlighted long-standing disparities in health by race and ethnicity. Current crises require examining and reorienting the systems that have, for decades, produced these health inequities; yet, public health and health care leaders are inadequately prepared to respond. The authors offer an equity-centered leadership framework to support the development of visionary leaders for tomorrow. This framework for leadership development programs interweaves traditional leadership and equity, diversity, and inclusion domains in both conceptual knowledge and skills-based teaching for health care and public health leaders, grouping competencies and skills into 4 domains: personal, interpersonal, organizational, and community and systems. A framework such as this will equip leaders with the mindset and skill set to challenge the paradigms that lead to inequity and health disparities.
What Sustains Residency Program Directors: Social and Interpersonal Factors That Foster Recruitment and Support Retention
Authors: Yager Joel , Anzia Joan M. , Bernstein Carol A. , Cowley Deborah S. , Eisen Jane L. , Forstein Marshall , Summers Richard F. , Zisook Sidney
Published: July 2022

Residency program directors’ careers follow several trajectories. For many, the role is relatively short term, lasting 3 to 5 years, during which time the program director may gain educational and administrative experience. However, a sizeable cohort of program directors have remained as program directors for a decade or more, and some have filled the role for the majority of their careers. Over the years, the role of the academic residency program director has become increasingly affected by administrative responsibilities, including scheduling, documentation, and reporting requirements, along with increasing clinical demands that may conflict with ensuring resident wellness and lead to insufficient time to do the job. Burnout in this role is understandable. Given these obstacles, why should any young faculty member choose to become a training director? The authors of this commentary have each served as a residency program director for decades, aggregating approximately 150 years of program director experiences. Based on their collective reflections, the authors describe social and interpersonal aspects of the program director role that have enhanced their professional satisfaction and well-being. These include overseeing residency cycle events from initial interviews through graduation and certification; assuming leadership and social roles in academic departments; counseling, mentoring, and assisting residents with work–personal life difficulties; and helping trainees and programs weather a variety of traumatic circumstances. These life-enriching experiences can compensate for the challenging aspects of these roles and sustain program directors through exceptionally rewarding careers.
No Significant Differences in Postoperative Complications Between Outpatient and Inpatient Single-level or Multiple-level Cervical Disk Replacement for Cervical Radiculopathy
Authors: Ifarraguerri Anna M. , Malyavko Alisa , Stoll William T. , Gu Alex , Thakkar Savyasachi C. , Patel Tushar
Published: July 2022

Study Design.

Retrospective cohort analysis.

Objective.

To investigate the safety profile of outpatient versus inpatient single-level and multiple-level cervical disk replacement (CDR) by analyzing one- and two-year surgical outcomes and 90-day medical complications using a large patient database.

Summary of Background Data.

CDR is becoming a more desirable option for patients undergoing cervical spine procedures. Unlike anterior cervical diskectomy and fusion, CDR is motion-preserving and has been shown to reduce rates of adjacent segment disease. Current literature investigating outpatient versus inpatient CDR has shown a similar safety profile among the two cohorts. However, most of these studies have relatively small sample sizes with short-term follow-up.

Materials and Methods.

A retrospective cohort study was done using the PearlDiver patient database between 2010 and 2019. Patients who underwent single-level and multiple-level CDR with a follow-up of at least two years were identified. Patients within each procedure cohort were subdivided into an outpatient and an inpatient group. Univariate and multivariable analyses were performed.

Results.

In total, 2294 patients underwent single-level CDR of which 506 patients underwent outpatient CDR and 1788 underwent inpatient CDR. In total, 236 patients underwent multiple-level CDR of which 49 patients underwent outpatient CDR and 187 underwent inpatient CDR. In the single-level CDR cohort, patients undergoing outpatient CDR were found to have lesser odds of a decompressive laminectomy at one year following the initial procedure (odds ratio=0.471; 95% confidence interval: 0.205–0.945; P=0.05). No significant differences in one- and two-year surgical complications, or 90-day postoperative complications, were found on multivariate analysis of outpatient versus inpatient multiple-level CDR.

Conclusion.

Our study found that performing single-level and multiple-level CDR on an outpatient basis has a similar safety profile to patients who underwent these procedures in an inpatient setting.

Level of Evidence.

3
Evidence for Monocyte Reprogramming in a Long-Term Postsepsis Study
Authors: Gritte Raquel Bragante , Souza-Siqueira Talita , Borges da Silva Eliane , dos Santos de Oliveira Laiane Cristina , Cerqueira Borges Rodrigo , Alves Heloísa H de Oliveira , Masi Laureane Nunes , Murata Gilson Masahiro , Gorjão Renata , Levada-Pires Adriana Cristina , Nogueira Antônio Carlos , Pithon-Curi Tânia Cristina , de Azevedo Ricardo Bentes , Soriano Francisco Garcia , Curi Rui , Machado Marcel Cerqueira Cesar
Published: July 2022

OBJECTIVES:

This study sought to identify monocyte alterations from septic patients after hospital discharge by evaluating gene expression of inflammatory mediators and monocyte polarization markers. It was hypothesized that sepsis reprograms the inflammatory state of monocytes, causing effects that persist after hospital discharge and influencing patient outcomes.

DESIGN:

The gene expression patterns of inflammatory receptors, M1 and M2 macrophage polarization markers, NLRP3 inflammasome components, and pro- and anti-inflammatory cytokines in monocytes were assessed.

PATIENTS:

Thirty-four patients from the University of São Paulo Hospital, during the acute sepsis phase (phase A), immediately after ICU discharge (phase B), and 3 months (phase C), 6 months (phase D), 1 year (phase E), and 3 years (phase F) after discharge, were included. Patients that died during phases A and B were grouped separately, and the remaining patients were collectively termed the survivor group.

MEASUREMENTS AND MAIN RESULTS:

The gene expression of toll-like receptor (TLR)2 and TLR4 (inflammatory receptors), NLRP3, NFκB1, adaptor molecule apoptosis-associated speck-like protein containing a CARD, caspase 1, caspase 11, and caspase 12 (NLRP3 inflammasome components), interleukin-1α, interleukin-1β, interleukin-18, and high-mobility group box 1 protein (proinflammatory cytokines), interleukin-10 (anti-inflammatory cytokine), C-X-C motif chemokine ligand 10, C-X-C motif chemokine ligand 11, and interleukin-12p35 (M1 inflammatory polarization markers), and C-C motif chemokine ligand 14, C-C motif chemokine ligand 22, transforming growth factor-beta (TGF-β), SR-B1, and peroxisome proliferator-activated receptor γ (M2 anti-inflammatory polarization and tissue repair markers) was upregulated in monocytes from phase A until phase E compared with the control group.

CONCLUSIONS:

Sepsis reprograms the inflammatory state of monocytes, probably contributing to postsepsis syndrome development and mortality.
Timing of Exposure to ICU Diaries and Its Impact on Mental Health, Memories, and Quality of Life: A Double-Blind Randomized Control Trial
Authors: Tripathy Swagata , Acharya Swati Priyadarshini , Sahoo Alok Kumar , Hansda Upendra , Mitra Jayanta Kumar , Goel Kishen , Ahmad Suma Rabab , Kar Nilamadhab
Published: July 2022

OBJECTIVES:

Optimal time for ICU diary delivery and impact on mental health (MH), anxiety-depression, post-traumatic stress symptoms (PTSS), quality of life (QOL), and memories is unclear. We evaluated the effect of ICU diaries, dispatched at different time points, on outcomes in an Indian cohort.

DESIGN:

Double-blind randomized controlled trial.

SETTING:

A 1,000-bedded teaching hospital in East India.

PATIENTS:

Mechanically ventilated (>24 hr) adults were recruited, excluding those dead or incapable of meaningful-communication at discharge or follow-up. Eighty-three patients, aged 46.2 ± 17.2 years, Acute Physiology and Chronic Health Evaluation II scores 13.7 ± 4.9 were assessed. Length of ICU stay was 8.2 ± 7.1 days with 3.7 ± 3.2 ventilator days.

INTERVENTION:

Of 820 screened, 164 had diaries created. Including photographs, diaries were comaintained by healthcare workers and family members. Ninety patients were randomized at 1-month follow-up: diary sent to 45 at 1 month (group ID1) and to 45 at 3 months (ID3).

MEASUREMENTS AND MAIN RESULTS:

Anxiety-depression, memory, and QOL were assessed telephonically or home visits by a psychologist using the Hospital Anxiety-Depression Scale (HADS) and other tools at ICU discharge, 1-month (prerandomization), and 3 months of discharge. ID3 was reassessed after receiving diaries at 3.5 months. Primary outcome was anxiety-depression; secondary outcomes included PTSS, QOL, and memories. There was 100% follow-up. At 3 months, ID1 patients had a significant (p < 0.001) reduction in HADS from baseline when compared with ID3 that had not received diaries (4.16 ± 2.9 vs 2.15 ± 1.8; 95% CI, 2.8–1.2). PTSS scores were likewise better (p < 0.001). ID3 patients demonstrated significant improvement (p < 0.01) in QOL and memories along with HADS and PTSS when assessed at 3.5 months.

CONCLUSIONS:

ICU diaries improve MH but not QOL when delivered at 1 month and assessed 2 months thereafter. Assessed after 15 days, delayed exposure at 3 months significantly improved QOL and memories in addition to MH.
Quality of Life of Pediatric Nurses During the COVID-19 Pandemic
Authors: Buccione Emanuele , Santella Beatrice , Fiani Maria Elena , Maffeo Marina , Tedesco Brigida , D'Errico Adelaide , Della Pelle Carlo , Bambi Stefano , Rasero Laura
Published: July 2022

Background

In a public health emergency, the psychological stress of nursing staff should be assessed, and nurses who cared for coronavirus disease 2019 (COVID-19) patients were constantly under pressure. Currently, frontline health care workers are experiencing mental health issues. The personal quality of life is directly related to the working environment, especially at this moment, when nursing could be a highly stressful and emotionally draining job.

Objectives

During the COVID-19 pandemic, the primary objectives of the study were to describe the quality of life, posttraumatic stress disorder, and self-efficacy and to identify any associated factors of pediatric critical care nurses. This study is a multicenter cross-sectional study.

Methods

Data were collected between February and May 2021 from pediatric critical care nurses. The following instruments were used: the Nursing Quality of Life Scale, the Nursing Profession Self-Efficacy Scale, and the Impact of Event Scale.

Results

One hundred twelve nurses participated in this study with a 40% of response rate. Data suggest a better global perception of quality of life by male subjects (F = 6.65, P = .011). The nurses who cared for COVID-19 patients reported a lower quality of social life (F = 4.09, P = .045); furthermore, the nurses who had clinically vulnerable people in their families reported a worse quality of physical life (F = 4.37, P = .045). Approximately 50% of nurses reported sleep disturbances, and 37% reported symptoms of posttraumatic stress disorder, especially female nurses (F = 8.55, P = .04).

Conclusion

According to this study, female nurses were more likely to experience posttraumatic stress disorder symptoms during the COVID-19 pandemic. Furthermore, findings also highlighted a lower quality of social life for those with clinically vulnerable relatives may be due to a self-limitation of interactions with other people. Finally, sleep disturbances were prevalent, potentially affecting nurses' mental health and performance.