bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring School Staff's Perceptions About Implementing Saliva‐Based Testing
Authors: Cheung W. C. , Ostrosky M. M. , O'Grady C. , Chudzik M. , Ackerman A. , Perez N. , Delinski N. , Smith R. L.
Published: July 2024

Background

To investigate the feasibility of conducting COVID‐19 testing in kindergarten‐grade 12 schools, saliva‐based testing was implemented in five schools. The purpose of this study was to understand staff's perspectives of the barriers and facilitators to conducting saliva‐based testing in their settings.

Methods

Thirty‐three school staff who worked in five target schools were interviewed in the summer of 2021. Participants were recruited from June–August 2021 via a flyer that was distributed through email and school‐affiliated social media and websites, and word‐of‐mouth. Semi‐structured interviews were conducted over Zoom by a trained interviewer; interviews were audio recorded and auto transcribed using this Zoom feature. Constant comparative analysis and emergent coding were used to analyze the data.

Results

The majority of participants had positive experiences with conducting saliva‐based testing during school hours. Participants reported that saliva‐based testing did not interrupt their school routine because (1) the testing was simple and quick, (2) the testing schedule was consistent and organized, and (3) school staff maintained open lines of communication. Barriers to implementing the testing were as follows: (1) obtaining parental consent, (2) not being allowed to drink or eat an hour before testing, and (3) struggling to provide enough saliva for testing. Participants suggested the following strategies to facilitate testing in schools: being more proactive, giving families fewer things to sign (i.e., consent forms), improving communication, adding needed consents to the school registration process, using social media, and increasing community outreach.

Conclusion

As schools weigh the benefits and the risks of closing for extended periods of time versus remaining open for in‐person learning, saliva‐based testing is a feasible and efficient way to support programs in this decision‐making process. This approach can be used in future pandemics and in areas with outbreaks or poor vaccine coverage.
Characterization of metabolic features and potential anti‐osteoporosis mechanism of pinoresinol diglucoside using metabolite profiling and network pharmacology
Authors: Tu Xin‐Pu , Wu Si‐Xian , Li Meng‐Yin , Chen Zi‐Hao , Liu Cheng‐Jun , Ruan Yan‐Jie , Zeng Jian‐Bin , Shi Wei , Liu Jian‐Hang , Zhang Feng‐Xiang
Published: July 2024

Rationale

Eucommia cortex is the core herb in traditional Chinese medicine preparations for the treatment of osteoporosis. Pinoresinol diglucoside (PDG), the quality control marker and the key pharmacodynamic component in Eucommia cortex, has attracted global attention because of its definite effects on osteoporosis. However, the in vivo metabolic characteristics of PDG and its anti‐osteoporotic mechanism are still unclear, restricting its development and application.

Methods

Ultra‐high‐performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry was used to analyze the metabolic characteristics of PDG in rats, and its anti‐osteoporosis targets and mechanism were predicted using network pharmacology.

Results

A total of 51 metabolites were identified or tentatively characterized in rats after oral administration of PDG (10 mg/kg/day), including 9 in plasma, 28 in urine, 13 in feces, 10 in liver, 4 in heart, 3 in spleen, 11 in kidneys, and 5 in lungs. Furan‐ring opening, dimethoxylation, glucuronidation, and sulfation were the main metabolic characteristics of PDG in vivo. The potential mechanism of PDG against osteoporosis was predicted using network pharmacology. PDG and its metabolites could regulate BCL2, MARK3, ALB, and IL6, involving PI3K‐Akt signaling pathway, estrogen signaling pathway, and so on.

Conclusions

This study was the first to demonstrate the metabolic characteristics of PDG in vivo and its potential anti‐osteoporosis mechanism, providing the data for further pharmacological validation of PDG in the treatment of osteoporosis.
Trial of labour after caesarean section in Sub‐Saharan Africa: A systematic review and meta‐analysis
Authors: Boatin Adeline A. , Cueto Paola D. , Garba Deen L. , Sawyer Michala , James Kaitlyn , Ngonzi Joseph , Lugobe Henry M. , Wylie Blair J. , Adu‐Bonsaffoh Kwame
Published: July 2024

Objective

The objective of this study is to determine the proportion of women undergoing trial of labour after caesarean (TOLAC) and vaginal birth after caesarean (VBAC) in Sub‐Saharan Africa (SSA), and to estimate associated adverse events.

Methods

We searched PubMed, MEDLINE, CAB, EMBASE and African‐specific databases from 1966 to July 2023, including SSA studies reporting on women with previous caesarean section (CS). We extracted data on study design, planned (TOLAC versus elective repeat CS (ERCS)) and actual delivery mode, and adverse outcomes. We calculated mean TOLAC and VBAC proportions, and pooled proportion of adverse events, comparing between TOLAC and ERCS where available. We assessed bias using the methodological index for nonrandomized studies.

Results

From 62 studies with 36 611 births, the estimated proportion undergoing TOLAC and achieving VBAC, adjusted for study variability, were 79% (95% confidence interval [95% CI]: 74%, 85%) and 47% (95% CI: 42%, 51%), respectively, for all births. Mean estimated uterine rupture proportion and maternal mortality were 2.1% (95% CI: 1.1%, 3.2%) and 0.1% (95% CI: 0.02%, 0.2%) respectively. We found no differences between TOLAC and ERCS for uterine rupture (1.2% vs. 0.2%, pooled odds ratio [OR]: 1.54; 95% CI: 0.63, 3.8) or maternal mortality (0.3% vs. <0.1%, pooled OR: 0.77; 95% CI: 0.30, 2.0), respectively. However perinatal mortality was higher with TOLAC compared to ERCS (5% vs. 1%; pooled OR: 3.3; 95% CI: 1.5, 6.9).

Discussion

We found high proportions of women undergoing TOLAC and moderate proportions of successful VBAC across SSA, with a higher perinatal mortality associated with TOLAC. Few studies reported on adverse outcomes and used inconsistent definitions. Further research is needed to understand outcomes in this population of women in these settings.

Registration

The study protocol was registered with PROSPERO (CRD42020175434).
Risk factors for non‐previa placenta accreta spectrum in pregnancies conceived through frozen embryo transfer during a hormone replacement cycle in Japan
Authors: Matsuo Seiko , Kotani Tomomi , Tano Sho , Ushida Takafumi , Imai Kenji , Nakamura Tomoko , Osuka Satoko , Goto Maki , Osawa Masami , Asada Yoshimasa , Kajiyama Hiroaki
Published: July 2024

Purpose

Non‐previa placenta accreta spectrum (PAS) is associated with assisted reproductive technology (ART), particularly frozen embryo transfer during hormone replacement therapy (HRC‐FET). We especially aimed to evaluate the prevalence and risk factors for non‐previa PAS in HRC‐FET pregnancies.

Methods

Overall, 279 women who conceived through ART at three ART facilities and delivered at a single center were included in this retrospective study. Data regarding endometrial thickness at embryo transfer, previous histories, and type of embryo transfer—HRC‐FET, frozen embryo transfer during a natural ovulatory cycle (NC‐FET), and fresh embryo transfer (Fresh‐ET)—were collected. Univariable logistic regression analyses were conducted.

Results

The prevalence of non‐previa PAS was 27/192 (14.1%) in the HRC‐FET group and 0 (0.0%) in both the NC‐FET and Fresh‐ET groups. Significantly high odds ratio [95% confidence interval] of non‐previa PAS was associated with a history of artificial abortion (6.45 [1.98–21.02]), endometrial thickness <8.0 mm (6.11 [1.06–35.12]), resolved low‐lying placenta (5.73 [2.13–15.41]), multiparity (2.90 [1.26–6.69]), polycystic ovarian syndrome (2.62 [1.02–6.71]), and subchorionic hematoma (2.49 [1.03–6.04]).

Conclusions

A history of artificial abortion, endometrial thickness <8.0 mm, and resolved low‐lying placenta may help in antenatal detection of a high‐risk population of non‐previa PAS in HRC‐FET pregnancies.
Interval observer design for unobservable switched nonlinear partial differential equation systems and its application
Authors: Song Xiaona , Peng Zenglong , Song Shuai , Stojanovic Vladimir
Published: July 2024

This paper designs an interval observer for switched nonlinear partial differential equation (PDE) systems. Initially, persistent dwell‐time switching rules are used to model switched PDE systems with fast and slow switching phenomena. Next, for unobservable systems caused by uncertainties, the interval observer for the target PDE systems is proposed by utilizing unknown but bounded information of the initial states, boundary conditions, external disturbances, and measurement noises. Subsequently, by utilizing the estimated state's upper and lower bounds, an interval observer‐based control strategy is devised to stabilize the studied systems, and sufficient conditions to ensure the stability of the target systems and the observation error dynamics are provided. Furthermore, the designed interval observer is employed to detect sensor failures in the presence of various uncertainties. Finally, two examples, including the lithium‐ion battery's temperature estimation and fault detection, are utilized to demonstrate the effectiveness of the obtained methods.
Practical prescribed‐time tracking control of unknown nonlinear systems: A low‐complexity approach
Authors: Xie Haixiu , Zhang Jin‐Xi , Jing Yuanwei , Chen Jiqing , Dimirovski Georgi M.
Published: July 2024

This article is concerned with the trajectory tracking control problem for the nonlinear systems in the sense of the predefined settling time and accuracy. In contrast with the existing works, we focus on the cases where the system dynamics, its bounding functions, the unmatched disturbances, and the time‐varying parameters are totally unknown; the derivatives of the desired trajectory are not required to be available. They significantly challenge the identification and/or approximation‐based control solutions. To overcome this obstacle, a novel robust prescribed performance control approach via state feedback is put forward in this article. It not only ensures the natural satisfaction of the specific initial condition but also realizes a full‐time performance specification for trajectory tracking. Furthermore, for the case of unmeasured state variables, an output‐feedback control approach is further derived by adopting an input‐driven filter and conducting trivial changes on the design procedure. Moreover, both approaches exhibit significant simplicity, without the needs for parameter identification, function approximation, disturbance estimation, derivative calculation, or command filtering. Three simulation studies are conducted to clarify and verify the above theoretical findings.
State‐dependent dynamic tube MPC: A novel tube MPC method with a fuzzy model of disturbances
Authors: Surma Filip , Jamshidnejad Anahita
Published: July 2024

Most real‐world systems are affected by external disturbances, which may be impossible or costly to measure. For instance, when autonomous robots move in dusty environments, the perception of their sensors is disturbed. Moreover, uneven terrains can cause ground robots to deviate from their planned trajectories. Thus, learning the external disturbances and incorporating this knowledge into the future predictions in decision‐making can significantly contribute to improved performance. Our core idea is to learn the external disturbances that vary with the states of the system, and to incorporate this knowledge into a novel formulation for robust tube model predictive control (TMPC). Robust TMPC provides robustness to bounded disturbances considering the known (fixed) upper bound of the disturbances, but it does not consider the dynamics of the disturbances. This can lead to highly conservative solutions. We propose a new dynamic version of robust TMPC (with proven robust stability), called state‐dependent dynamic TMPC (SDD‐TMPC), which incorporates the dynamics of the disturbances into the decision‐making of TMPC. In order to learn the dynamics of the disturbances as a function of the system states, a fuzzy model is proposed. We compare the performance of SDD‐TMPC, MPC, and TMPC via simulations, in designed search‐and‐rescue scenarios. The results show that, while remaining robust to bounded external disturbances, SDD‐TMPC generates less conservative solutions and remains feasible in more cases, compared to TMPC.
Distributed optimal consensus via PI regulation for high‐order nonlinear agents over directed networks
Authors: Wu Wenqiang , Xu Hongyu , Wang Qingling
Published: July 2024

This paper studies the optimal consensus problem of high‐order nonlinear agents under digraphs by PI regulation. A new type of adaptive PI variables is proposed for the first time, which is independent of the global information of graphs and complex dynamics. With the proposed variables, a key lemma is derived to transform the optimal consensus problem into a regulation problem, such that classical control techniques are used to regulate the adaptive PI variables for more complex dynamics. We also develop a new kind of distributed control algorithms based on the adaptive PI variables, Nussbaum‐type functions, and neural networks (NN). The proposed algorithms achieve the optimal consensus for high‐order nonlinear agents with nonidentical unknown control directions, bounded disturbances, and input saturation over weight‐unbalanced directed networks. Finally, a simulation example is provided to illustrate the effectiveness of the proposed algorithms.
Values‐based food procurement: Black farmers and structural racism in New York State
Authors: Gilbert‐Overland Jessica L.
Published: July 2024

Responding to growing calls for system dynamics (SD) research to engage with structural racism, this article examines the barriers that Black farmers in New York State face and explores values‐based public institutional food procurement (VBFP) as one possible solution for overcoming these barriers. Combining a qualitative data analysis with causal loop diagrams, this analysis reveals that ongoing structural racism generates (1) structural disconnects between Black farmers' and public institutions' supply chains that inhibit their integration; and (2) procurement policies that create new, rather than addressing existing, barriers for Black farmers. VBFP initiatives' potential to support Black farmers is thus dependent upon dismantling structural racism. In addition, this article advances SD supply chain research by examining one effort to align supply chains with social and environmental values and demonstrates how causal loop diagrams, with their emphasis on system structure, reveal why values‐based supply chain efforts in general often struggle. © 2024 System Dynamics Society.
Minding the abstraction gap: approaches supporting implementation
Authors: Black Laura J. , Greer Donald R.
Published: July 2024

Regardless of insights gained from building and analyzing dynamic models, the only strategies people can act on are those in their heads. The strategies people internalize are related to their perceived capacities to act—the verbs they believe they can do. If we want others to implement model‐informed policies, then we must connect model abstractions with new situated, concrete actions stakeholders can take. We can emphasize opportunities to act with SD representations, navigating levels of abstraction cleanly, identifying flows as verbs, and choosing variable names that signal who is acting. By drawing on social‐science theories as we offer our grammar of accumulations, activities, and relationships in the language of actions accessible to stakeholders, we help connect experiential understandings to richer, dynamic explanations people can internalize and so discover situated steps to implement policies informed by modeling. © 2024 The Author(s). System Dynamics Review published by John Wiley & Sons Ltd on behalf of System Dynamics Society.
Long‐Durability, Surfactant‐Free, and Bifunctional Ir‐Doped Pt3Co/MWCNTs Electrocatalysts towards ORR and OER in Acidic Media
Authors: Wang Qiang , Li Chuang , Li Guangwei , Li Xiao , Luo Sai , Xing Danmin , Liang Changhai
Published: July 2024

Developing cost‐effective, high‐performance, and durable electrocatalysts for oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) is pivotal for advancing hydrogen energy conversion and storage technologies. Simultaneously, establishing scalable methods for their production is essential for the widespread adoption of these renewable energy solutions. In this study, we present a successful large‐scale synthesis of surfactant‐free iridium‐doped Pt−cobalt nanoparticles supported on multiwalled carbon nanotubes (Ir−Pt3Co/MWCNTs). This composite demonstrates significantly enhanced ORR and OER activity compared to commercial Pt/C and IrO2 in acidic environments. The Ir−Pt3Co/MWCNTs catalyst composite exhibits a low overpotential of 357 mV at 10 mA cm−2 and a remarkable mass activity of 0.594 A/mgPt. Investigating the influence of Ir doping content on ORR and OER, we found that Pt3Co0.6Ir0.4/MWCNTs showcased the most superior activity in both reactions. We present a reproducible protocol for the synthesis of surfactant‐free Ir−Pt3Co nanoparticles supported on MWCNTs, yielding a bifunctional catalyst capable of efficiently catalyzing both ORR and OER with outstanding efficiency and stability in acidic media. Detailed X‐ray photoelectron spectroscopy (XPS) analysis elucidates the electron transfer between atoms, optimizing the electronic structure and adjusting the position of the d‐band. This optimization enhances the electrocatalytic activity and structural stability of the catalysts, contributing to their superior performance in ORR and OER.
Comparison of Polysaccharide Profiles of Different Seaweeds Based on Ion Chromatography and Ultrahigh‐Performance Liquid Chromatography
Authors: Fan Jing , Gu Donglin , Xv Weiyi , Zhou Tingting , Chen Anzhen , Lu Jingguang , Wang Ying , Jin Hongyu , Wei Feng , Ma Shuangcheng
Published: July 2024

In traditional Chinese medicine research, seaweeds used for drug and health food development mainly refer to Sargassum pallidum (Turn.) C. Ag. (SP) and Sargassum fusiforme (Harv.) Setch. (SF). In the Chinese Pharmacopoeia, polysaccharides are the main quality control indicators. The total sugar content is determined by the anthrone–sulfuric acid method to evaluate the quality of seaweeds. However, this method cannot reflect the structural characteristics of seaweed polysaccharides and cannot distinguish among different seaweed varieties. Given this, to comprehensively evaluate the quality of different seaweeds, this study conducted a thorough analysis of the primary structure of polysaccharides in 11 batches of SF and 7 batches of SP. The neutral sugar content was determined by the anthrone–sulfuric acid colorimetric method, weight average molecular weight (Mw) by high‐performance size exclusion chromatography coupled with multi‐angle laser light scattering and refractive index detector method, sulfate content by ion chromatography and monosaccharide composition by ultrahigh‐performance liquid chromatography method, while also using professional software for statistical and similarity analysis. The results showed significant differences (p < 0.05) in neutral sugar content and Mw between S. fusiforme polysaccharides and S. pallidum polysaccharides, which can be used to distinguish SF and SP. The monosaccharide composition fingerprint was analyzed using chemometric methods, and it was found that fucose and glucose could serve as differential markers to distinguish SF and SP. This study further deepens the understanding of polysaccharides in seaweeds and more comprehensively evaluates the quality of different seaweeds.
Optimizing Ultrasonic‐Assisted Extraction for Enhanced Yield of Phenolic Compounds and Antioxidant Activity in Cold Brew Coffee
Authors: Boonmee Naruemon , Narkprasom Nukrob , Jaturonglumlert Somkiat , Tandee Kanokwan , Rattanawongwiboon Thitirat , Narkprasom Kanjana
Published: July 2024

This study aimed to identify the best conditions for ultrasonic‐assisted extraction (UAE) of DPPH and phenolic compounds from cold brew coffee using Box‐Behnken Design (BBD) and Response Surface Methodology (RSM). It explored the effects of solid‐liquid ratio (5%–15%), extraction time (40–50 min), and ultrasonic power (70%–80%) on these compounds, finding that all factors significantly influenced the outcomes. Statistical analysis showed the data fit a quadratic polynomial model well, with R2 values of 0.9981 for phenolic compounds and 0.9799 for DPPH radicals. Using 3D surface and contour plots from these models, the optimal extraction conditions for these compounds from cold brew coffee were determined. The highest yields of total phenolic compounds and DPPH radical were obtained when samples were extracted at a 10% solid–liquid ratio, 45 min extraction time, and 75% ultrasonic power. Under these optimal conditions, total phenolic compounds and DPPH radical were 64.10 ± 0.31 gGAE/mL and 61.90 ± 0.14%, respectively, with a maximum caffeine content of 213.13 ± 0.23 mg/L. Gamma irradiation at kGy also reduced cold brew coffee's microbial content. This research may be a new alternative for producing cold brew coffee that will save time and help extend the shelf life.
Low secondary risks for turkey vultures from a sodium nitrite toxic bait for wild pigs
Authors: Foster Justin A. , Kinsey John C. , Lavelle Michael J. , VerCauteren Kurt C. , Snow Nathan P.
Published: July 2024

An acute and orally‐delivered toxic bait for wild pigs (Sus scrofa) containing sodium nitrite (SN) is being developed and tested for potential registration in the U.S. We evaluated oral toxicity of SN and risk of secondary consumption in a common avian scavenger, the turkey vulture (Carthartes aura), by 1) conducting an acute oral toxicity test (LD50) for turkey vultures by oral gavage, and 2) allowing turkey vultures to feed on whole carcasses and digestive tracts of wild pigs that died from consuming SN‐laden bait. Captive tests were conducted during fall 2016 and spring 2017 in the Wild Pig Research Facility at Kerr Wildlife Management Area, Hunt, Texas, USA. We estimated the LD50 of SN for turkey vultures at 659 mg/kg. None of the turkey vultures died or exhibited any symptoms of SN‐toxicity from consuming whole carcasses, or digestive tracts of wild pigs that were poisoned with SN. We concluded that the risks of secondary poisoning to turkey vultures are low, which agrees with previous work on another scavenger, the coyote (Canis latrans). Overall, we found no evidence to suggest that 2 common scavengers would be at risk of acute mortality from consuming wild pigs that were poisoned with SN.
Determination of macro‐ and microelements concentrations by wavelength‐dispersive X‐ray fluorescence spectrometry in the objects of the technogenic ecosystem
Authors: Shtel'makh Svetlana I. , Zhilicheva Alena N. , Vasil'eva Irina E.
Published: July 2024

The wavelength‐dispersive X‐ray fluorescence (WDXRF) spectrometry was applied to determine Na, Mg, Al, P, S, K, Ca, Cr, Mn, Fe, Ni, Cu, Zn, Sr, Ba, and Pb concentrations in the needles of dwarfish spruce Picea canadensis conica and the blue prickly spruce Picea pungens glauca, as well in technogenic soil of Irkutsk city, in which these spruce species grow. All measurements were performed in vacuum using WDXRF spectrometer S8 TIGER produced by Bruker AXS, Germany. The calculated values of instrumental limit of detection (ILD) ranged from 0.5 for Ni to 67 mg/kg for Al for soil certified reference materials (CRMs) such as OOKO151 (light chestnut soil) and from 0.2 for Cu and Ni to 18–24 mg/kg for Na for the plant CRMs such as LB‐1 (birch leaf) and EC‐1 (Canadian waterweed). The repeatability is satisfactory. The values of relative standard deviations (RSDs) do not exceed 15% for soils and available plant material. With calculated T‐statistics, it was found that the WDXRF data do not contain systematic errors. The values of relative discrepancy for WDXRF, total reflection X‐ray fluorescence (TXRF) spectrometry, and atomic emission spectrometry with arc discharge (d.c. arc‐AES) results do not exceed 30% for studied elements.
w1+∞ in 4D gravitational scattering
Authors: Himwich Elizabeth , Pate Monica
Published: July 2024

Abstract

In four-dimensional asymptotically flat spacetimes, an infinite tower of soft graviton modes is known to generate the symmetry algebra of w1+∞ at tree-level. Here we demonstrate that the symmetry action follows from soft graviton theorems and acts non-trivially on massive scalar particles. By generalizing previous analyses that were specifically tailored to the scattering of massless particles, our results clarify that w1+∞ symmetry is a universal feature of tree-level gravitational scattering in four-dimensional asymptotically flat spacetimes and originates from minimally-coupled gravitational interactions. In addition, we show that the w1+∞ symmetry acts non-diagonally on massive states by mixing an infinite number of conformal families. We also present a concrete example of non-local behavior on the celestial sphere in the presence of massive scattering states.
Mixmaster chaos in an AdS black hole interior
Authors: De Clerck Marine , Hartnoll Sean A. , Santos Jorge E.
Published: July 2024

Abstract

We derive gravitational backgrounds that are asymptotically Anti-de Sitter, have a regular black hole horizon and which deep in the interior exhibit mixmaster chaotic dynamics. The solutions are obtained by coupling gravity with a negative cosmological constant to three massive vector fields, within an Ansatz that reduces to ordinary differential equations. At late interior times the equations are identical to those analysed in depth by Misner and by Belinskii-Khalatnikov-Lifshitz fifty years ago. We review and extend known classical and semiclassical results on the interior chaos, formulated as both a dynamical system of ‘Kasner eras’ and as a hyperbolic billiards problem. The volume of the universe collapses doubly-exponentially over each Kasner era. A remarkable feature is the emergence of a conserved energy, and hence a ‘time-independent’ Hamiltonian, at asymptotically late interior times. A quantisation of this Hamiltonian exhibits arithmetic chaos associated with the principal congruence subgroup Γ(2) of the modular group. We compute a large number of eigenvalues numerically to obtain the spectral form factor. While the spectral statistics is anomalous for a chaotic system, the eigenfunctions themselves display random matrix behaviour.
Gravitational waves from cosmic superstrings and gauge strings
Authors: Marfatia Danny , Zhou Ye-Ling
Published: July 2024

Abstract

We perform a phenomenological comparison of the gravitational wave (GW) spectrum expected from cosmic gauge string networks and superstring networks comprised of multiple string types. We show how violations of scaling behavior and the evolution of the number of relativistic degrees of freedom in the early Universe affect the GW spectrum. We derive simple analytical expressions for the GW spectrum from superstrings and gauge strings that are valid for all frequencies relevant to pulsar timing arrays (PTAs) and laser interferometers. We analyze the latest data from PTAs and show that superstring networks are consistent with 32 nHz data from NANOGrav, but are excluded by 3.2 nHz data at 3σ unless the string coupling gs< 0.2 or the strings evolve in only about 10% of the volume of the higher-dimensional space. We also point out that while gauge string networks are excluded by NANOGrav-15 data at 3σ, they are completely compatible with EPTA and PPTA data. Finally, we study correlations between GW signals at PTAs and laser interferometers.
Shedding black hole light on the emergent string conjecture
Authors: Basile Ivano , Lüst Dieter , Montella Carmine
Published: July 2024

Abstract

Asymptotically massless towers of species are ubiquitous in the string landscape when infinite-distance limits are approached. Due to the remarkable properties of string dualities, they always comprise Kaluza-Klein states or higher-spin excitations of weakly coupled, asymptotically tensionless critical strings. The connection between towers of light species and small black holes warrants seeking a bottom-up rationale for this dichotomoy, dubbed emergent string conjecture. In this paper we move a first step in this direction, exploring bottom-up constraints on towers of light species motivated purely from the consistency of the corresponding thermodynamic picture for small black holes. These constraints shed light on the allowed towers in quantum gravity, and, upon combining them with unitarity and causality constraints from perturbative graviton scattering, they provide evidence for the emergent string scenario with no reference to a specific ultraviolet completion.
Quark flavor violation and axion-like particles from top-quark decays at the LHC
Authors: Cheung Kingman , Chung Fei-Tung , Cottin Giovanna , Wang Zeren Simon
Published: July 2024

Abstract

We study axion-like particles (ALPs) with quark-flavor-violating couplings at the LHC. Specifically, we focus on the theoretical scenario with ALP-top-up and ALP-top-charm interactions, in addition to the more common quark-flavor-diagonal couplings. The ALPs can thus originate from decays of top quarks which are pair produced in large numbers at the LHC, and then decay to jets. If these couplings to the quarks are tiny and the ALPs have $$ \mathcal{O}(10) $$
O

10

GeV masses, they are long-lived, leading to signatures of displaced vertex plus multiple jets, which have the advantage of suppression of background events at the LHC. We recast a recent ATLAS search for the same signature and reinterpret the results in terms of bounds on the long-lived ALP in our theoretical scenario. We find that the LHC with the full Run 2 dataset can place stringent limits, while at the future high-luminosity LHC with 3 ab−1 integrated luminosity stronger sensitivities are expected.
Generalized eikonal identities for charged currents
Authors: Plestid Ryan
Published: July 2024

Abstract

We discuss QED radiative corrections to contact operators coupling two heavy fields and one light field. These operators appear ubiquitously in weak interactions with nuclei such as beta decay and neutrino nucleus scattering. New eikonal identities are derived in the static limit (i.e., neglecting nuclear recoil) that allow for manifest power counting of enhancements proportional to the charge of the nucleus. We apply these new identities to nuclear beta decays and find that the “independent particle model” used by Jaus, Rasche, Sirlin & Zucchini is closely related, though not identical, to a model independent effective field theorcalculation.
Lazy neutrophils – a lack of DGAT1 reduces the chemotactic activity of mouse neutrophils
Authors: Uchańska Alicja , Morytko Agnieszka , Kwiecień Kamila , Oleszycka Ewa , Grygier Beata , Cichy Joanna , Kwiecińska Patrycja
Published: July 2024

Background

Neutrophils are key players in the innate immune system, actively migrating to sites of inflammation in the highly energetic process of chemotaxis. In this study, we focus on the role of acyl-CoA: diacylglycerol acyltransferase 1 (DGAT1), an enzyme that catalyzes the synthesis of triglycerides, the major form of stored energy, in neutrophil chemotaxis.

Methods and results

Using a mouse model of psoriasis, we show that DGAT1-deficiency reduces energy-demanding neutrophil infiltration to the site of inflammation, but this inhibition is not caused by decreased glycolysis and reduced ATP production by neutrophils lacking DGAT1. Flow cytometry and immunohistochemistry analysis demonstrate that DGAT1 also does not influence lipid accumulation in lipid droplets during inflammation. Interestingly, as has been shown previously, a lack of DGAT1 leads to an increase in the concentration of retinoic acid, and here, using real-time PCR and publicly-available next-generation RNA sequencing datasets, we show the upregulation of retinoic acid-responsive genes in Dgat1KO neutrophils. Furthermore, supplementation of WT neutrophils with exogenous retinoic acid mimics DGAT1-deficiency in the inhibition of neutrophil chemotaxis in in vitro transwell assay.

Conclusions

These results suggest that impaired skin infiltration by neutrophils in Dgat1KO mice is a result of the inhibitory action of an increased concentration of retinoic acid, rather than impaired lipid metabolism in DGAT1-deficient mice.
An analytical approach for the performance calculation of an RCS/RS with several picking stations
Authors: Trost Philipp , Eder Michael
Published: July 2024

Robotic Compact Storage and Retrieval Systems (RCS/RS) offer numerous advantages, including high performance, scalability, and availability, which are essential for modern logistics and warehousing. However, information on the potential performance of RCS/RS is limited, primarily due to the diverse range of configurations available. This paper aims to address this gap by developing an analytical approach to predict the throughput of an RCS/RS with multiple robots serving several picking stations. The approach considers various parameters such as grid size, stack height, number of robots, and filling degree, alongside kinematic data. The cycle time for each robot is calculated assuming a uniform distribution of container stacks. Subsequently, a queueing system with limited capacity is constructed using performance data from a single robot. The analytical approach is validated using a discrete event simulation model of an RCS/RS. Following the validation, an extensive parameter variation and application example are conducted to demonstrate the versatility of the approach. This method offers a straightforward and efficient set of formulas for determining RCS/RS throughput, easily solvable using standard table or algebra programs.
Impact of heart failure severity on the mortality benefit of mitral transcatheter edge-to-edge valve repair
Authors: Magni Valeria , Adamo Marianna , Pezzola Elisa , Rubbio Antonio Popolo , Giannini Cristina , Masiero Giulia , Grasso Carmelo , Denti Paolo , Giordano Arturo , De Marco Federico , Bartorelli Antonio L. , Montorfano Matteo , Godino Cosmo , Baldi Cesare , De Felice Francesco , Mongiardo Annalisa , Monteforte Ida , Villa Emmanuel , Crimi Gabriele , Tusa Maurizio , Testa Luca , Serafini Lisa , Cani Dario , Guarini Giacinta , Huqi Alda , Sesana Marco , De Carlo Marco , Maisano Francesco , Tarantini Giuseppe , Tamburino Corrado , Bedogni Francesco , Metra Marco
Published: July 2024

Background

To assess the interaction between heart failure (HF) severity and optimal reduction of secondary mitral regurgitation (SMR) on mortality in patients undergoing transcatheter edge-to-edge repair (M-TEER).

Methods and results

Among 1656 patients included in the Italian Society of Interventional Cardiology (GIse) registry Of Transcatheter treatment of mitral valve regurgitaTiOn (GIOTTO) 984 had SMR and complete data on advanced HF. Advanced HF was defined as NYHA class III or IV, left ventricular ejection fraction ≤ 30%, and > 1 HF hospitalization during the last 12 months. Optimal M-TEER was defined as residual SMR ≤ 1 + at discharge. One hundred sixteen patients (11.8%) had advanced HF. Achievement of an optimal SMR reduction was similar in patients with and without advanced HF (65% and 60% respectively). Advanced HF was an independent predictor of 2-year all-cause death (adjusted HR 1.52, 95% CI 1.09–2.10). Optimal M-TEER, as compared to a no-optimal M-TEER, was associated with a reduced risk of death both in patients with advanced (HR 0.55, 95% CI 0.32–0.97; p = 0.039) and no-advanced HF (HR 0.59, 95% CI 0.46–0.78; p < 0.001; p = 0.778 for interaction).

Conclusions

Advanced HF is associated with poor outcome in patients undergoing M-TEER. However, an optimal SMR reduction reduces the risk of 2-year mortality regardless of HF severity.

Graphical Abstract
Quantitative assessment of intertarget position variations based on 4D-CT and 4D-CBCT simulations in single-isocenter multitarget lung stereotactic body radiation therapy
Authors: Zhang Siyu , Guo Chang , Xu Jun , Qian Pudong , Guo Jiali , Liu Tingting , Wu Yifan , Hong Jun , Wang Qi , He Xia , Sun Li
Published: July 2024

Background

In single-isocenter multitarget stereotactic body radiotherapy (SBRT), geometric miss risks arise from uncertainties in intertarget position. However, its assessment is inadequate, and may be interfered by the reconstructed tumor position errors (RPEs) during simulated CT and cone beam CT (CBCT) acquisition. This study aimed to quantify intertarget position variations and assess factors influencing it.

Methods

We analyzed data from 14 patients with 100 tumor pairs treated with single-isocenter SBRT. Intertarget position variation was measured using 4D-CT simulation to assess the intertarget position variations (ΔD) during routine treatment process. Additionally, a homologous 4D-CBCT simulation provided RPE-free comparison to determine the impact of RPEs, and isolating purely tumor motion induced ΔD to evaluate potential contributing factors.

Results

The median ΔD was 4.3 mm (4D-CT) and 3.4 mm (4D-CBCT). Variations exceeding 5 mm and 10 mm were observed in 31.1% and 5.5% (4D-CT) and 20.4% and 3.4% (4D-CBCT) of fractions, respectively. RPEs necessitated an additional 1–2 mm safety margin. Intertarget distance and breathing amplitude variability showed weak correlations with variation (Rs = 0.33 and 0.31). The ΔD differed significantly by locations (upper vs. lower lobe and right vs. Left lung). Notably, left lung tumor pairs exhibited the highest risk.

Conclusions

This study provide a reliable way to assess intertarget position variation by using both 4D-CT and 4D-CBCT simulation. Consequently, single-isocenter SBRT for multiple lung tumors carries high risk of geometric miss. Tumor motion and RPE constitute a substantial portion of intertarget position variation, requiring correspondent strategies to minimize the intertarget uncertainties.
QAFI: a novel method for quantitative estimation of missense variant impact using protein-specific predictors and ensemble learning
Authors: Ozkan Selen , Padilla Natàlia , de la Cruz Xavier
Published: July 2024

Next-generation sequencing (NGS) has revolutionized genetic diagnostics, yet its application in precision medicine remains incomplete, despite significant advances in computational tools for variant annotation. Many variants remain unannotated, and existing tools often fail to accurately predict the range of impacts that variants have on protein function. This limitation restricts their utility in relevant applications such as predicting disease severity and onset age. In response to these challenges, a new generation of computational models is emerging, aimed at producing quantitative predictions of genetic variant impacts. However, the field is still in its early stages, and several issues need to be addressed, including improved performance and better interpretability. This study introduces QAFI, a novel methodology that integrates protein-specific regression models within an ensemble learning framework, utilizing conservation-based and structure-related features derived from AlphaFold models. Our findings indicate that QAFI significantly enhances the accuracy of quantitative predictions across various proteins. The approach has been rigorously validated through its application in the CAGI6 contest, focusing on ARSA protein variants, and further tested on a comprehensive set of clinically labeled variants, demonstrating its generalizability and robust predictive power. The straightforward nature of our models may also contribute to better interpretability of the results.
Insight into Details of Chemical Exchange Kinetics Studied by NMR CPMG Method
Authors: Stepišnik Janez , Mohorič Aleš
Published: July 2024

A more detailed insight into the chemical kinetics and dynamics of chemical exchanges within a molecule or between molecules in liquids is made possible by the NMR CPMG method, which, in addition to the exchange rate, gives its power spectrum, which contains information about the underlying processes of chemical exchange. The applicability of the method is demonstrated by measuring the chemical exchange in an aqueous solutions of sucrose, whose rate spectra have shapes that cannot be explained as transitions in a double potential well, but after interpretation using the chemical Langevin equations, it can be explained as a cascading chemical transition across several intermediate potential walls.
Green urban transition: interdisciplinary insights on green façades design in hot climates as one of crucial strategies for low-carbon development
Authors: Chojnacka Katarzyna , Widera Barbara , Macarulla Marcel , Drougkas Anastasios , Balastegui Andreu , Van de moortel Els , Şık Cansu Iraz Seyrek , Sadowski Kajetan , Fernandes Joana , Gomes Ricardo , Ferrão Paulo
Published: July 2024

The purpose of this study is to present interdisciplinary insights on vertical green systems (VGS) design in hot climate zones. The approach to the VGS design proposed in this article combines architectural design, structural systems, green building and township development with sustainable urban farming, circularity, waste and water management. On the basis of in-depth study on green façade performance in hot climates, the authors identified methods derived from various fields of science which, when correctly combined, enable effective protection of plants against excessive solar radiation. The main finding of the research is the identification of the most effective combination of methods supporting healthy growth of the VGS. This set of solutions includes orientation of the façade to cardinal directions correlated with appropriate plants selection, shading strategies, such as passive and kinetic shields and organic fertilizers supporting plants’ resilience. The authors presented key challenges and opportunities of VGS application and discussed their role in the decarbonization process of the building sector. The multidisciplinary analysis of the state of knowledge highlighted areas that require further investigation, such as the practical implementation of proposed strategies and their effectiveness in real-world scenarios.

Graphical abstract
Creating dialogues as a quiet revolution: exploring care with women in regenerative farming
Authors: Aare Ane Kirstine , Umantseva Anna , Sørensen Laura Brandt
Published: July 2024

Around the world, practitioners and academics are engaging in the rise of regenerative farming. On the margins of the predominant farming system, and often with little support and acknowledgement, regenerative farming is surprisingly persistent and represents a radical response to industrialization, ecological crises and alienation. This study uses feminist theories to grasp farmers’ regenerative experiences and explores how dialogical methodologies can create collective thinking among farmers and between academia and practice. The study is based on dialogues and iterative writing between three female researchers and two female regenerative farmers in Denmark in which we explore regenerative farming practices, female perspectives, feminist (more-than-human) care, and the sustainability crises we are facing today and in the future. The exchange of thoughts provides insights into what it is to be human in farming, including more-than-human relationships, as well as reflections on composting as a reproductive practice, and the (quiet) revolutionary potential of regenerative farming. Thus, we experience how creating collective thinking about common concerns across academia and practice can entail feelings of being part of a community as well as involve actual consequences and risks. Finally, it reminds us that sharing fragility by laying bare our work (and thoughts) as both researchers and practitioners allows for careful dialogues and valuable insights.
Condom Failure Among HIV-Negative Men in Serodiscordant Relationships in Australia, Brazil, and Thailand
Authors: Gray James , Prestage Garrett , Jin Fengyi , Phanuphak Nittaya , Friedman Ruth K. , Fairley Christopher K. , Templeton David J. , Zablotska-Manos Iryna , Hoy Jennifer , Bloch Mark , Baker David , Brown Graham , Grulich Andrew , Bavinton Benjamin ,   for the Opposites Attract study group, Grulich Andrew E , Zablotska Iryna B , Prestage Garrett P , Bavinton Benjamin R , Grinsztejn Beatriz , Cooper David A , Kelleher Anthony , Emery Sean , Fairley Christopher K , Wilson David , Koelsch Kersten K , Triffitt Kathy , Doong Nicolas , Templeton David J , McNulty Anna , Pell Catherine , Tee Ban Kiem , Moore Richard , Roth Norm , Orth David , Pinto Angie N
Published: July 2024

Condoms continue to be used by many gay, bisexual, and other men who have sex with men (GBM) to reduce the risk of HIV transmission. However this is impacted by condom failure events, defined here as condom breakage and slippage. In a prospective, observational cohort study of 343 HIV serodiscordant male couples recruited through high HIV caseload clinics and hospitals between 2012 and 2016 in Australia, Brazil, and Thailand, condom failure rates and associated factors were analysed, including with the study partner versus other sexual partners. There were 717 reported instances of condom failure from an estimated total of 25,831 sex acts with condoms, from over 588.4 participant years of follow up. Of the HIV-negative partners (n = 343) in the study, more than a third (n = 117, 36.7%) reported at least one instance of condom failure with any partner type during study follow-up. Condom failure with their study partner was reported by 91/343 (26.5%) HIV-negative partners, compared with 43/343 (12.5%) who reported condom failure with other partners. In total, there were 86 events where the HIV-negative partner experienced ano-receptive condom failure with ejaculation, representing 12.0% of all failure events. In multivariable analysis, compared to Australia, HIV-negative men in Brazil reported a higher incidence risk rate of condom failure (IRR = 1.64, 95%CI 1.01–2.68, p = 0.046) and HIV-negative men who reported anal sex with other partners reported an increased risk of condom failure compared with men who only had sex with their study partner (IRR = 1.89, 95%CI 1.08–3.33, p = 0.025). Although at least one event of condom failure was reported by a significant proportion of participants, overall condom failure events represented a small proportion of the total condom protected sex acts.
A Provider-Focused Intervention to Increase Universal HIV Testing among Adolescents in School-Based Health Centers
Authors: Hoffman Neal D. , Ciarleglio Adam , Lesperance-Banks Susanna , Corbeil Tom , Kaur Harpreet , Silver Ellen J , Bauman Laurie , Sandfort Theo G. M.
Published: July 2024

We describe a provider-focused intervention to increase universal HIV testing among adolescent users in a network of School-Based Health Centers (SBHC) and compare the rate of HIV test offer and acceptance for SBHCs with and without the HIV testing intervention. The intervention was implemented at the six largest SBHCs in the 12-site network and included system- and staff-level initiatives, including an implementation coach to support SBHC associates. Rates of HIV test offer and acceptance at six sites in the Intervention Cohort were compared to that at the six sites in a Non-Intervention Cohort which was not randomly selected but had comparable distributions by age, gender and race/ethnicity. The model showed an intervention effect for universal HIV test offer, but no overall effect for test acceptance. Analyzing the intervention effect by whether a patient had a history of sexual activity, the intervention was very effective early in its implementation at increasing test offer to those with no history of sexual activity, and late in its implementation at increasing test acceptance for those with no or unknown sexual activity. Increasing and sustaining universal HIV testing in SBHCs may benefit from using Implementation Science frameworks to guide adaptation of the intervention.