bluuebunny/crossref_metadata_2025 huggingface dataset:
Colorectal cancer screening future modalities among Saudi population: national questioner
Authors: alharbi mohammed
Published: April 2023

Background: Understanding how the general public feels about the method of colorectal cancer screening is crucial since early diagnosis of cancer through the colorectal cancer screening program lowers mortality rates.
Methods: The purpose of this study was to determine the most popular technique of colorectal cancer screening in Saudi Arabia. From September 2021 to February 2022, a cross-sectional study using an adult Saudi population was undertaken. On an internet platform, a self-created survey was given to the general public. All statistical analyses were carried out using SPSS version 26 and data were tabulated using Google Forms.
Results: out of 10781 participants were analysed, out of them ,we found 5612 are suitable for analysis between colonoscopy and faecal immunochemical test (FAIT) population preference for colorectal cancer screening modalities. we found that gender, employment and age were important predicators for the preferred screening modality.
Conclusion: More attention should be paid to the population's preferred method of colorectal cancer screening, which could increase the success of the screening effort.
Over-reliance on water infrastructure erodes the resilience of
drylands pastoralists
Authors: Baldassarre Giuliano Di , Piemontese Luigi , Terzi Stefano , Schwieger Diego Menestrey , Castelli Giulio , Bresci Elena
Published: April 2023

Extreme droughts are affecting millions of livestock farmers in Sub-Saharan Africa, causing water shortages, famines, migration, and fatalities. The construction of new small water infrastructures (e.g., wells, boreholes, and small dams) is increasingly supported by NGOs and national governments to improve water availability for agro-pastoralists, especially as an emergency response to extreme droughts. While the short-term benefits of small water infrastructure are clear, their potential cumulative impact and their long-term effects on the resilience of drylands communities remain unclear. Building on in-depth anthropological literature from five key African drylands, we model post-drought pastoralists' dynamics related to small water infrastructure. We show that while developing new water points releases water shortages in the short term, it can erode the traditional adaptation practices without adequate governance. This can cause unexpected long-term impacts, such as sedentism, overgrazing, rangeland degradation, and groundwater depletion. We further illustrate how our model captures early quantitative signals of resilience loss in dryland Angola, where large-scale implementation of small water infrastructure is being delivered in response to the worst droughts ever recorded in the pursuit of increasing climate resilience.
Development and validation of a prognostic model based on SEER data for patients with Combined small-cell lung cancer
Authors: Qie Shuai , Shi Hongyun , Luan Jiusong , Yuan Lanhui , Peng Yu , Liu Fangyu
Published: April 2023

Background: To analyze the prognostic factors of combined small cell lung cancer (CSCLC) and construct a nomogram model for CSCLC.
Methods:
A total of 978 patients diagnosed with CSCLC from 2010 to 2015 were collected based on the SEER database. According to the ratio of 7:3, the patients were divided into the modeling group and the testing group. Univariate and multivariate Cox regression analyses were performed on the patients in the modeling group to analyze the independent factors affecting the prognosis of CSCLC patients and construct a nomogram prediction model, which was verified by the C-index and calibration curve in the training cohort and the validation cohort, respectively.
Results:
Univariate and multivariate Cox regression analysis showed that N stage, M stage, surgery, chemotherapy, radiotherapy, age, brain metastases, lung metastases, liver metastases, bone metastases, and tumor size were independent risk factors affecting the prognosis of CSCLC patients (P<0.05). A nomogram prediction model was constructed based on the above 10 risk factors through visual analysis, and the C-index was 0.753 (95%CI: 0.727~0.750). The calibration curves showed good agreement between the 1 -, 2 -, and 3-year predicted and actual survival rates of the prediction model constructed in this study. The AUC of the 1-, 2-, and 3-year prediction models was 0.813, 0.814, and 0.802, respectively. DCA showed that the nomogram model had more clinical application value in predicting survival prognosis than TNM staging. Finally, according to the total score of the nomogram survival prediction model, all the included cases were divided into low-risk, intermediate-risk, and high-risk strata and these three survival curves of each risk stratification showed significant survival differences (p< 0.05).
Conclusions:
The nomogram prediction model constructed in this study has higher accuracy and clinical application value than the traditional TNM staging. It can predict the 1 -, 2 - and 3-year OS of patients individually and provide a new tool for clinicians to evaluate the survival prognosis of CSCLC. The risk stratification system established by this model can identify high-risk patients more quickly, and make follow-up plans and subsequent treatment plans more targeted.
Clinical and biological factors predisposing to hyperkalemic renal tubular acidosis in solid organ transplant recipients : a retrospective monocentric study
Authors: Mohib Othmane , Vanderhulst Julien , Catalano Concetta , Roussoulières Ana , Knoop Christiane , Baudoux Thomas
Published: April 2023

Background The occurrence of hyperkalemic renal tubular acidosis in the post-transplantation period is likely underestimate, and its identification remains important to offer adequate medical management. Transplanted recipients frequently present clinical and biological characteristics which are associated in the literature with the occurrence of this complication. Post-transplant exposure to drugs that cause hyperkalemic renal tubular acidosis may therefore appear risky. We conducted a single-center retrospective comparative study in which we compared patients with hyperkalemic renal tubular acidosis and a control group to identify clinical and biological factors significantly associated with this complication.Methods The Fisher’s exact test was applied to test whether there is a significant association between hyperkalemic renal tubular acidosis and qualitative variable. The Mann-Whitney test was applied for the quantitative variables. We performed a multivariate logistic regression excluding some variables and then selected the variables using a stepwise procedure. The best logistic model according to the Akaike Information Criterion was the final model.Results Kidney and heart transplant recipients appear to be at greater risk of developing this complication than lung transplant recipients (p = 0.016). No other qualitative variable showed a significant association with the occurrence of hyperkalemic RTA. We also found a significant difference in kalemia (p < 0.01), chloremia (p < 0.01), and bicarbonatemia (p < 0.01).Neither the residual serum tacrolimus level (p = 0.19) nor the creatinine level of renal transplant patients (p = 0.17) was significantly associated with hyperkalemic renal tubular acidosis. In multivariate logistic regression, the analysis of the final model confirms the significant impact of kalemia (p < 0.01), chloremia (p < 0.01), and bicarbonatemia (p = 0.013) in the occurrence of this complication.Conclusion In our study, the type of transplanted organ, kalemia, chloremia, and bicarbonatemia seem to be significantly associated with the occurrence of hyperkalemic renal tubular acidosis. It is essential to identify this complication and to treat hyperkalemia first before proposing additional treatments. Larger studies are needed to more accurately define transplanted patients at risk for hyperkalemic renal tubular acidosis.
TABHATE: A Target-based Hate Speech Detection Dataset in Hindi
Authors: Sharma Deepawali , Singh Vivek Kumar , Gupta Vedika
Published: April 2023

Social media has over the years provided a medium for creation and dissemination of opinions and thoughts through online platforms. While it allows users to express their views, sentiments and emotions, some people try to use it to generate and share unpleasant and hateful content. Such content is now referred to as hate speech and it may target an individual, a group, a community, or a country. During the last few years, several techniques have been developed to automatically detect and identify hate speech, offensive and abusive content from social media platforms. However, majority of the studies focused on hate speech detection in English language texts. With social media getting higher penetration across different geographies, there is now a significant amount of content generated in various languages. Though there have been significant advancements in algorithmic approaches for the task, the non-availability of suitable dataset in other languages poses a problem in research advancement in them. Hindi is one such widely spoken language where such datasets are not available. This work attempts to bridge this research gap by presenting a curated and annotated dataset for target-based hate speech (TABHATE) in the Hindi language. The dataset comprises of 2,020 tweets and is annotated by three independent annotators. A multiclass labelling is used where each tweet is labelled as: (i) individual targeting, (ii) community targeting, and (iii) none. Inter annotator agreement is computed. The suitability of dataset is then further explored by applying some standard deep learning and transformer-based models for the task of hate speech detection. The experimental results obtained show that the dataset can be used for experimental work on hate speech detection of Hindi language texts.
Export stability, income growth, and North-South difference
Authors: Li Lin , Ding Yunuo , Wang Yijia , Fan Jiachen
Published: April 2023

This paper examines the effect of export stability on income inequality in north and south countries. We use products level data to measure export stability and apply several IV strategies that allows us to estimate the impact of export stability on income with much greater precision. Our main finding is that export stability has a positive effect on the income growth of developing countries but no effect on developed countries, implying that export stability leads to a significant reduction in income inequality between the north and south countries. Furthermore, we show that in developing countries, the effect of export stability operates through an increase in income expectation and inventory management efficiency; the improvement of business environment and product complexity enhances the effect of export stability; the increase of government size may decrease the effect of trade instability. Finally, we show third country effect doesn’t directly influence income growth.
Almost Finite-time Synchronization for Coronary Artery Systems via Adaptive Fractional-powered-integral-type Sliding Mode Control Method
Authors: YANG Chi-Hsin , YANG Ruizhao , Liang Chuanjian , LIAN Wenwu , CHEN Hong-Yi , WANG Kun-Chieh
Published: April 2023

From the cardiac medical viewpoint, the treatment for a vasospasm caused by the diseased coronary artery system (CAS) is to synchronize the dynamic behavior of a diseased CAS with that of a healthy CAS such that the physiological change of the CAS is improved. In this study, for the bio-mathematical model of CAS, the novel fractional-powered-integral-type finite-time-convergent sliding mode (FFSM), which is consisted of the fractional powered and the integral terms of the state variables, is introduced. The adaptive sliding mode control method based on the defined FFSM is proposed for achieving the almost finite-time synchronization between two CASs. Once the developed control is in action, the special type of stability is exhibited. That is, the two error states are stabilized in the sequel on the sliding surface, which induces the almost finite-time stability owing to the property of the model for CAS. The adaptive FFSM control scheme, which includes three online updated gains with the rules of adaption, can counter the nonlinear dynamical effects of the synchronized error system. Numerical experiments are executed to show the validation of the present scheme.
Evidence of Polariton-Version Quantum Cherenkov Radiations
Authors: Wang Lei , Zheng Jia-Xin , Cui Lin , Liu Xue-Qing , Luo Yang , Chen Qi-Dai , Wang Haiyu
Published: April 2023

Strong similarities for relativistic electrons stimulated from electron beams and electron clouds are merging the boundary of wave-particle duality of electrons, one of which being superposition is Cherenkov radiations. Recent quantum Cherenkov effects for non-point particles predict electron-spin flip transitions in bound- and free-electron systems like bulk dielectrics and graphene, which, however, haven’t been experimentally exemplified to date. Here, we report an analogous polariton-version quantum Cherenkov radiation, where double-cone emission processes of Cherenkov-type phonon polaritons (PhPs) and derivatives in ultrashort-pulse-stimulated ferroelectric crystals and graphene are originated from transient non-point electron wave packets, and material-specific low-frequency cutoffs are due to electron-spin flipping. Component analysis of double-cone polariton emissions is achieved by a unified quantum dynamics model, and initial polariton dynamics including abnormal backward cones in graphene are restored. The resulting quantum wave packets of PhPs are further correlated with femtosecond-laser-induced modifications inside ferroelectric lithium niobates, which realize a PhP threshold criterion for ultrasmooth femtosecond laser nanofabrication.
Occlusion Robust Sign Language Recognition System for Indian Sign Language Using CNN and Pose Features
Authors: DAS SOUMEN , Biswas Saroj kr. , Purkayastha Biswajit
Published: April 2023

The Sign Language Recognition System (SLRS) is a cutting-edge technology that aims to enhance communication accessibility for the deaf community in India by replacing the traditional approach of using human interpreters. However, the existing SLRS for Indian Sign Language (ISL) do not focus on some major problems including occlusion, similar hand gesture, multi viewing angle problem and inefficiency due to extracting features from a large sequence of frame that contains redundant and unnecessary information. Therefore, in this research paper an occlusion robust SLRS named Multi Featured Deep Network (MF-DNet) is proposed for recognizing ISL words. The suggested MF-DNet uses a histogram difference based keyframe selection technique to remove redundant frames. To resolve occlusion, similar hand gesture, and multi viewing angle problem the suggested MF-DNet incorporates pose features with Convolution Neural Network (CNN) features. For classification the proposed system uses Bi Directional Long Shor Term Memory (BiLSTM) network, which is compared with different classifier such as LSTM, ConvLSTM and stacked LSTM networks. The proposed SLRS achieved an average classification accuracy of 96.88% on the ISL dataset and 99.06% on the benchmark LSA64 dataset. The results obtained from the MF-DNet is compared with some of the existing SLRS where the proposed method outperformed the existing methods.
App-delivered cognitive-behavioral therapy for insomnia among patients with comorbid musculoskeletal complaints and insomnia referred to 4-week inpatient multimodal rehabilitation: protocol for a randomized clinical trial
Authors: Skarpsno Eivind Schjelderup , Simpson Melanie Rae , Seim Arnfinn , Hrozanova Maria , Bakøy Marthe Alida , Klevanger Nina Elisabeth , Aasdahl Lene
Published: April 2023

Background: Insomnia is prevalent among patients receiving treatment for long-term musculoskeletal complaints in inpatient rehabilitation settings. Cognitive-behavioral therapy for insomnia (CBT-I) is effective for improving sleep quality in patients with pain, but a lack of therapists often limits the capacity to use this therapy in rehabilitation programs. The aim of this randomized clinical trial (RCT) is to evaluate the effectiveness of app-delivered CBT-I adjunct to inpatient multimodal rehabilitation for individuals with comorbid musculoskeletal complaints and insomnia, compared with rehabilitation (usual care) only.
Methods. This RCT has two parallel arms: 1)inpatient multimodal rehabilitation and 2)app-delivered CBT-I adjunct to inpatient multimodal rehabilitation. Patients referred to Unicare Helsefort (Norway) with long-term chronic musculoskeletal complaints are invited to the study. Eligible and consenting participants will be randomized to the intervention and usual care at a ratio of 2:1. Outcomes are collected at baseline, at the end of rehabilitation (6 weeks), 3 months, 7.5 months, and 13.5 months of follow-up. The primary outcome is insomnia severity measured at 3 months. Secondary outcomes include pain intensity, health-related quality of life, sick leave, and prescribed medication. Exploratory analyses are planned to identify moderators and mediators of the effect of the app-delivered intervention. We will also conduct a process evaluation that will assess facilitators and barriers for treatment adherence and a qualitative study to explore how the participants experience the use of digital therapy.
Discussion:This RCT will provide novel knowledge about the effectiveness of app-delivered CBT-I as an adjunct to usual care among patients participating in inpatient multimodal pain rehabilitation. Regardless of the results from this trial, the results will improve our understanding of the utility of dCBT-I in the field of rehabilitation and the importance of adding sleep therapy to this patient group.
Trial registration: This trial was prospectively registered in ClinicalTrials.gov October 10, 2022 (ClinicalTrials.gov identifier: NCT05572697).
Study on protein hydrolysate from Symplectoteuthis oualaniensis reconstructing fibroblast against oxidative stress by hydrogen peroxide
Authors: Li Na , Diao Xiaozhen , Pu Xinyi , Tang Pengjie , Elango Jeevithan , Wu Wenhui
Published: April 2023

The free radical hypothesis has been accepted in the researching of skin aging. As a small molecule oxidant, hydrogen peroxide (H2O2) is easily induce the apoptosis of HSF cells through biofilm system. Oxidative stress caused by H2O2also leads to the synthesis of inflammatory cytokines, mainly including interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), which are involved in the regulation of skin inflammation and irritation. Protein protease hydrolysates were prepared from Iris cuttlefish (Symplectoteuthis oualaniensis) and then investigated for their antioxidant activitiesin vitro. The positive effect by PHCSO (protease hydrolysates from the carcass ofSymplectoteuthis oualaniensis) on the reconstruction of HSF (human skin fibroblasts) cells against oxidative stress was investigated by the oxidative stress model via H2O2inducement. PHCSO-1 or PHCSO-2 was a mixed peptide whose molecular weight is over 10 kDa or less 10 kDa from the ultrafiltration of PHCSO. The reconstructing effect of PHCSO-2 was superior to that of PHCSO on HSF cells according to the results from cell morphology of fluorescence staining, inflammatory factors and antioxidant activity analysis. 5 mg/mL PHCSO-2 showed the DPPH and hydroxyl radical scavenging activity as 57.96% and 56.86% respectively, with TNF-α reduced by 24.83%, which indicated the effective protection on skin from oxidative stress. The protein hydrolysate fromSymplectoteuthis oualaniensiswas proved to be the marine antioxidant peptide, which could be applied in cosmetics, pharmaceutical or food industries.
Simple and secure thrombectomy involving peripheral pulmonary arteries for acute pulmonary embolism
Authors: Sasaki Hanae , Kowatari Ryosuke , Kondo Norihiro , Minakawa Masahito
Published: April 2023

Background:
Surgical pulmonary artery thrombectomy is a well-established emergency treatment for massive pulmonary embolism (PE) in which fibrinolysis or thrombolysis are not effective. However, surgery for massive PE that requires peripheral pulmonary artery thrombus removal remains challenging. We established a simple and secure pulmonary artery thrombectomy method using cardiopulmonary bypass and cardiac arrest. In this procedure, the surgical assistant arm, typically used for coronary artery bypass grafting, is used to obtain a feasible working space during thrombectomy.
Case presentation:
We present seven consecutive massive PE cases that were treated with the present surgical method and successfully weaned from cardiopulmonary bypass or extracorporeal membrane oxygenation postoperatively.
Conclusions:
This procedure can be used to prevent right ventricular failure after surgery as surgeons can remove the peripheral thrombus with clear vision up to the second branch of the pulmonary artery.
The relationship between antisocial personality and drug craving in Chinese male methamphetamine-dependent patients: the mediating role of alexithymia
Authors: Li Yanli , Wang Dongmei , Zhou Huixia , Tian Yang , Chen Jiajing , Zhu Rongrong , Li Yuqing , Fan Fusheng , Fu Fabing , Wei Dejun , Tang Shanshan , Xiangyang Zhang
Published: April 2023

Background In patients with methamphetamine use disorder (MUD), antisocial personality disorder (ASPD) and alexithymia increase the risk of drug craving, but the relationship between the three of them is unclear. Therefore, this study explored the mediating role of alexithymia in the relationship between ASPD and drug craving.Methods We recruited 524 MUD patients at a drug rehabilitation center in Sichuan Province, China, and assessed ASPD with the Mini International Neuropsychiatric Interview (M.I.N.I.), methamphetamine craving with the Desire for Drugs Questionnaire (DDQ), and alexithymia with the Toronto Affective Disorder Scale (TAS-20).Results Compared with MUD patients without ASPD, MUD patients with ASPD had higher DDQ-desire and intention, DDQ-negative reinforcement and DDQ-total scores, as well as TAS-total and their subscale scores (all p < 0.05). Correlation analyses revealed a significant positive correlation between ASPD, alexithymia and drug craving. Mediating effect analysis further indicated that the relationship between ASPD and drug craving was mediated by alexithymia.Conclusions Our study demonstrates for the first time that alexithymia mediates the relationship between ASPD and drug craving, which may provide a new entry point for treating MUD with comorbid ASPD.
Depressive symptomatology and NT-proBNP and Health status in Heart Failure
Authors: Balata Mahmoud , Westenfeld Ralf , Hassan Marwa , Pfister Roman , Zimmer Sebastian , Nickenig Georg , Becher Marc Ulrich , Conrad Rupert
Published: April 2023

Background: Although depression symptoms are common among heart failure (HF) patients, there is little consensus regarding the relationship between depressive symptoms and NT-proBNP, the key HF marker. Therefore, this study aimed to investigate this relationship and assess the impact of depressive symptoms on the health status and clinical outcomes of HF patients.
Methods: 151 patients with HF were enrolled in the study and followed up for one year. Depressive symptoms and health status were assessed by the Hospital Anxiety and Depression Scale (HADS-D) and the Kansas City Cardiomyopathy Questionnaire (KCCQ), respectively.
Results: At baseline, the median HADS-D score was 5 (3 - 8) points. Patients with HADS-D scores > 5 points had significantly higher NT-proBNP levels (p = 0.043), and significantly lower KCCQ-OSS and KCCQ-CSS (p < 0.001 for both KCCQ scores).
From baseline to the last assessment after one year the percentage changes in the HADS-D scores were significantly positively correlated with the percentage changes in the levels of NT-proBNP (r = 0.22, p = 0.009). It was also significantly negatively correlated with the changes in KCCQ-OSS (r = -0.34, p < 0.001) and KCCQ-CSS (r = -0.19, p = 0.021).
Moreover, baseline HADS-D score was an independent predictor of the percentage changes in NT-proBNP from baseline to the last assessment (ß = 3.91, p = 0.03), even after adjustment for age, sex, baseline LVEF and creatinine (ß = 3.99, p = 0.02).
In a Cox regression analysis baseline HADS-D score had a significant impact on the cardiovascular mortality, which remained consistent even after adjustment for age, sex, and baseline LVEF, NT-proBNP and creatinine (hazard ratio = 1.18, 95% CI = 1.0 – 1.4, p = 0.048).
Conclusions:
1. There is a significant correlation between depressive symptoms, NT-proBNP, and health status in HF patients.
2. Baseline HADS-D score has a significant impact on the cardiovascular mortality in HF patients.
Low Frequency DD-DWT based illumination compensated and color intensified features for Face Recognition
Authors: Chaudhary Juhi , Yadav Jyotsna
Published: April 2023

The efficacy of face recognition systems is significantly affected by uneven light deviations, incident over images from different directions. This work presents a light invariable color face recognition method that efficiently normalizes illumination variances along with substantial improvement in color intensities. The proposed method includes following steps: Initially, segregation of facial images into primary spectral color components is performed to effectively balance contrast and evenly amplify color intensity levels. The varying illumination effects are due to low frequency component of image; therefore, Difference of Gaussian (DoG) high-pass filter based homomorphic filtering is further utilized in HSI (Hue, Saturation and Intensity) space. This conversion into HSI color space is mainly performed to ward off any colors distortion that may prevail in images due to direct utilization of further improvements on each color channel. Thus, this model aids in easily separating the chromaticity component from intensity part of an image. The normalized intensity component is concatenated with unaltered chromaticity components to effectively possess color facial information. Subsequently, extraction of double density discrete wavelet transform (DD-DWT) based coefficients of images is achieved for selection of substantial discriminative frequency components of face images. The large facial feature vector space is hereafter projected over eigen subspace to reduce dimensions effectively. In this work, k-nearest neighbor linear classifier has been utilized to classify selective features. The effectiveness of investigated method has been assessed on AR and CMU-PIE color face databases and attained results are thus contrasted with prior techniques which benefit in establishing its superiority.
Evaluation of the distribution of plant pressure of the feet in qualified badminton players when performing functional tests
Authors: BALTIN Maxim , FEDIANIN Artur , SAMIGULLIN Bulat , MAVLIEV Fanis , BALTINA Tatyana
Published: April 2023

Backgroundː The aim of this study was to compare changes in plantar pressure distribution during normal stance lunges and service by professional badminton players. Methodsː The study involved 12 badminton players. The Tekscan HR pedobarographic platform (USA) was used to record data. Resultsː The results showed that both the forefoot and the hindfoot were loaded differently depending on the stage of the delivery being performed or the posture adopted. In the area of the midfoot, metatarsals and toes of the left foot, the peak pressure was lower, and the highest value was in the 3rd metatarsal during a calm stance. An analysis of changes in pressure on the foot after loading, however, relative to the initial stance showed a trend in the distribution of load on the outer surface in the left foot. On the right foot, in contrast, toe use decreased by 50%, but heel support increased by 20%, and midfoot pressure increased by 20%. During the delivery in the swing phase, there was an increase in pressure in the area of the heel of the unsupported leg. In the lunge phase, the pressure was distributed over the entire plantar surface, however, the pressure distribution remained uneven with an area of greater pressure in the heel and lateral part of the metatarsus. Conclusionsː It is recommended to introduce exercises into the training process aimed at preventing and correcting the correct position of the feet in order to reduce the risk of injuries to the ankle and knee joints.
Delayed Enterocutaneous Fistula After 17 Years of Colon Anastomosis in a Gunshot Wound injury : A case report
Authors: Nur Nuradin Mohamed , ahmed Abdullahi abdi
Published: April 2023

Introduction: enterocutaneous fistula is a common complication of abdominal surgery. Postoperatively, it may be the result of a small intestinal injury or an anastomosis leak, and it typically manifests days or weeks following surgery.
Presentation of the case: A 56-year-old man with a history of gunshot wound injury in the abdomen, with colon injury managed for colocolic anastomosis seventeen years earlier prsented to our hospitals general surgery clinic with the complain of drainage at the scar area. It was discovered that he had an enterocutaneous fistula. The patient underwent a laparotomy. Fistula tract excision and segmental colon resection with colocolic anastomosis were done.
Discussion Enterocutaneous fistula formation after an extraordinarily long latency due to an anastomotic leak, which hasn't been previously documented in the literature, is a distinctive aspect of the case. As a result, surgeons should consider ECF in their differentials for patients with a history of abdominal operations.
Conclusion: Surgical management is the definitive treatment of enterocutaneous fistula after proper resuscitation and stabilization of the patient's condition. Preoperative imaging is crucial for determining the anatomy of the fistula and any associated intra-abdominal pathology.
Assessment of Pollution Stae of Beire Lake in Sri Lanka Using Water Quality Index, Trophic Status and Principal Component Analysis
Authors: Dharmarathna Dilshi , Galagedara Ridmi , Himanujahn Sivaperumaan , Karunaratne Shiromi , Athapattu Bandunee
Published: April 2023

Beira Lake, in the heart of Colombo City in Sri Lanka, is a prominent landmark, serving a variety of important services such as flood control, and providing habitat and nesting grounds for the city's wildlife. During the past decades, Beira Lake has become highly polluted due to anthropogenic activities. The majority of the past restoration attempts failed, revealing a lack of understanding of the pollutant intricacies. The objective of this study is to investigate the trophic status of all four basins of the lake to investigate the pollution status. Thirty sampling locations were selected based on a 100×100 m grid to cover the entire lake. Water Quality Index (WQI) and Trophic Level Index (TLI) were calculated to further investigate the pollution scenarios. WQI, total nitrogen, Total phosphorous, Secchi depth, and Chlorophyll-a (Chl-a) were considered to calculate the TLI of the lake. As per the WQI more than 93% of the lake's surface area, is in poor condition. The TLI reveals the hypereutrophic status of the lake water. According to principle component analysis, eutrophication and algal bloom index observed can be due to the heavy anthropogenic activities and land use patterns around the catchment indicating a high possibility of untreated effluent entering the lake through the active inlets. The effluent entering the lake should be managed immediately to prevent further deterioration of the entire lake. Immediate restoration of the lake is recommended, as the hypereutrophic state may lead to irreversible an imbalance in the lake ecosystem.
Investigation of wear behavior of 34CrNiMo6 low alloy steel coated by PACVD method
Authors: naftchalie Yaser Mahdavi , Qods Fathallah , Ghasemi Behrooz
Published: April 2023

Despite favorable and various properties, low-alloy steels lack appropriate surface properties and strength. Accordingly, low-alloy steel 34CrNiMo6 was coated by the PACVD process. To this end, resources to supply titanium, nitrogen, and carbon were used in the coating composition. The methane flow rate is the main variable to create coatings with different compositions and thicknesses. The resulting coatings were studied and analysed in terms of mechanical properties and microstructure by EDS, AFM, FESEM, GIXRD, and XPS. The results showed that the C3N4 phase formed in the compositions improved the tribological properties of the coatings. Increasing the methane flow rate insignificantly affected the carbon content of the coatings.
Design of a Novel Load Balanced Multi-Sink Based Hierarchical Data Gathering Protocol for Wireless Sensor Networks
Authors: Biswal Sanjay Kumar , Samal Tusharkanta , Mohanty Prabhudutta , Mishra Manas Ranjan , Barik Ram Chandra
Published: April 2023

The diverse applications of Wireless sensor Networks (WSNs) significantly influences many aspect of human society and life style. One of the prominent research objective of WSNs is to prolong the network life span without degrading its performance. Many researchers have developed cluster based routing and data aggregations technique to meet the above requirements. However, a significant amount of energy has been consumed during cluster formation technique. Therefore, a hierarchical clustering data gathering protocol for multi sink architecture has been proposed. The optimal numbers of sink nodes have been placed to limit communication overhead. In addition to this Additive Silent and Zero Start approach has been adopted to manage the traffic load that increases the lifespan of WSN. The simulation has been carried out in Network Simulator (NS2) and the proposed method outperforms than its existing counterparts with respect to energy consumption, delay, miss ratio and packet delivery ratio.
RAPD and SRAP analysis reveal genetic diversity and clustering based on seed productivity in tree peony (Paeonia ostii)
Authors: Ho Un-Hyang , Kim Il Jin , Kim Hye Song , Song Sam Rang , An Chol Ho , Ri Hak Song , Kim Tong Ryul , Mun Hye Gyong
Published: April 2023

Tree peony is a shrub plant of great economic value due to its large and beautiful flowers, seeds containing much oil, root used as medicine. Understanding the genetic diversity and relationship of the tree peony cultivars is of great significance in facilitating breed and cultivar maintenance. In this study, we analysed genetic diversity and clustering of eight cultivated tree peony (Paeonia ostii) lines in Democratic People’s Republic of Korea using RAPD and SRAP primers. Dendrogram analysis indicates that eight lines were divided into two groups (Cluster I: D1, D2, D3, Cluster II: N1, N2, N3, N4, N5), which is consistent with clustering based on seed productivity. Clustering analysis based on STRUCTURE analysis and PCA analysis supports the phylogenetic analysis results. The RAPD and SRAP primers used in this study could be used to facilitate breeding, cultivar identification and maintenance to increase seed productivity.
Finding k-community structures in special graph classes
Authors: Baghirova Narmina , Dallard Clément , Ries Bernard , Schindl David
Published: April 2023

For a fixed integer $k\ge 2$, a \emph{$k$-community structure} in an undirected graph is a partition of its vertex set into $k$ sets called \textit{communities}, each of size at least two, such that every vertex of the graph has proportionally at least as many neighbours in its own community as in any other community. In this paper, we give a necessary and sufficient condition for a forest on $n$ vertices to admit a $k$-community structure. Furthermore, we provide an $\mathcal{O}(n^{2})$-time algorithm that computes such a $k$-community structure in a forest, if it exists. These results extend a result of [Bazgan et al., Structural and algorithmic properties of $2$-community structure, Algorithmica, 80(6):1890-1908, 2018]. We also show that if communities are allowed to have size one, then every forest with $n \geq k\geq 2$ vertices admits a $k$-community structure that can be found in time $\mathcal{O}(n^{2})$. We then consider threshold graphs and show that every connected threshold graph admits a $2$-community structure if and only if it is not isomorphic to a star; also if such a $2$-community structure exists, we explain how to obtain it in linear time. We further describe two infinite families of disconnected threshold graphs, containing exactly one isolated vertex, that do not admit any $2$-community structure. Finally, we present a new infinite family of connected graphs that may contain an even or an odd number of vertices without $2$-community structures, even if communities are allowed to have size one.
A new automated strategy for optimizing inclined interplanetary low-thrust trajectories
Authors: Burhani B. M. , Fantino E. , Flores R. , Sanjurjo-Rivo M.
Published: April 2023

This study proposes a new automated strategy for designing and optimizing three-dimensional interplanetary low-thrust (LT) trajectories. The method formulates the design as a hybrid optimal control problem and solves it using a two-step approach. In Step 1, a three-dimensional model based on generalized logarithmic spirals is used with heuristics in combination with a gradient-based solver to perform an automated multi-objective global search of trajectories and optimize for parameters defining the spirals, the launch date, as well as the number, sequence and configuration of the planetary flybys. In Step 2, candidate solutions from Step 1 are refined by further optimization with a direct method. Results show that, compared to similar algorithms based on two-dimensional models, the strategy implemented in Step 1 leads to better estimates of the optimal trajectories, especially when the orbits of the involved bodies are inclined with respect to the ecliptic plane. The proposed approximate method (Step 1) yields better agreement with high-fidelity solutions (Step 2) in terms of launch, flyby and arrival dates, in-plane and out-of-plane average LT accelerations and propellant consumption, leading to improved convergence when the Step 1 trajectories are employed to initiate the search in Step 2.
Preparation, characterization, and in vitro evaluation of the anticancer activity of Ce 3+ doped CuFe 2 O 4 spinel nanoparticles in MCF- 7 cell lines
Authors: Sheena T. V , Jyothish B. , Jacob John
Published: April 2023

In the current study, Ce-doped Copper ferrite, CuCexFe2-xO4(x=0.00, 0.03, and 0.05) particles in the nano range were prepared successfully by using the chemical co-precipitation technique. The structure, composition, optical properties, and morphological information of the obtained ferrite nanoparticles (NPs) were analyzed by making use of powder X-Ray diffraction (PXRD) pattern, Field Emission Scanning Electron Microscopic (FE-SEM) studies, Fourier Transform Infrared Spectroscopic (FT-IR) analysis, and Energy-dispersive X-Ray Spectroscopy (EDS), and the UV-Vis-NIR Spectroscopy. The MTT [3- 9(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide] test was utilized to examine the in vitro anti-cancer activities against the breast cancer MCF-7 cell line, which shows the dose-dependent cell survival within the range of concentration 6.25µg/mL-100µg/mL. In vitro cytotoxicity studies have shown that CuCexFe2-xO4 (x = 0.05) nanoparticles (NPs) were proved to be safe at lower concentrations, indicating their biocompatibility. However, higher concentrations (>25 g/mL) of the NPs lowered the cell viability and disrupted the cell lines of L929 fibroblasts. The ability of the nanoparticles to induce apoptosis in human breast cancer cells were studied by double staining method and flow cytometry and it was noted that apoptosis is one of the mechanism by which it induces cytotoxic effect on MCF-7 cell lines.
CD117+/CXCR4+ stem cell mobilization is associated to SDF1α, IL-6 and -8 in off-pump coronary revascularization open heart surgery
Authors: Polanco-Lozada Juan Rafael David , Hernandez Maria Esther Ocharan , Castillo Guillermo García , Quiroz Guillermo Díaz , Martínez Silvia Cortez , Estrada Luis Felipe Montaño , Chimal José Luis Aceves
Published: April 2023

Myocardial function recovery in ischemic cardiomyopathy patients requires engraftment of hematopoietic stem cells and coronary artery bypass grafting. Bypass surgery produces an inflammatory response that probably influences bloodstream stem cell mobilization. Although off-pump coronary surgery minimizes myocardial inflammation, the surgical bypass procedure produces myocardial inflammation thus influencing myocardial regeneration. Our aim was to determine if the inflammation associated to the bypass surgical procedure favors CD117+/CXCR4+ stem cell bloodstream mobilization. Method: Ten ml blood samples of 20 patients undergoing off-pump coronary revascularization open heart surgery were obtained pre-surgery, at the sternotomy moment, during Left Internal Thoracic Artery grafting, and at sternotomy closure. 1 ml of total blood was used to quantitate CD117+/CXCR4+ cells by flow cytometry with Specific monoclonal antibodies (BioLegend), whereas the remaining blood was used to obtain serum to evaluate IL-6, 8, TNFα, and SDF1α by chemiluminescence. Results: Pre-surgery IL-6 (10.2 pg/ml) and IL8 (18.6 pg/ml) serum concentration began to increase at the moment of sternotomy and reached their peak (79.1 and 28.4 pg/ml, respectively) at sternotomy closure; the already meaningful increase of IL-6 during Left Internal Thoracic Artery grafting (32.5 pg/ml) was associated with a significantly increase in SDF1α serum concentration (199 pg/ml vs 8.6 pg/ml pre-surgery value) and CD117+/CXCR4 + cell numbers (375x103 cells/ml vs 4x103 cell/ml pre-surgery value) that diminished to 114x103 cells/ml at sternotomy closure. Conclusion: CD117+/CXCR4+ stem cell mobilization in off-pump coronary artery bypass surgery is mediated by an increase in SDF1α result of an enhanced IL-6 and IL-8 serum concentration.
Long Intergenic Non-Coding RNA— Linc00659— Expression Changes in Gastric Cancer
Authors: Abdolzadeh Elmira , Abdi Esmat , Latifi-Navid Saeid , Zahri Saber , kholghi-Oskooei Vahid , Yazdanbod Abbas
Published: April 2023

Purpose Gastric cancer (GC) as a multifactorial disease is caused by environmental, infectious, and genetic factors. The aberrant expression of lncRNAs has been considered as a crucial feature of human cancer. In this research, we assessed the expression levels of a linc00659 in GC patients.Methods Expression of linc00659 in tumor and non-tumor tissues (a total of 82 samples) was evaluated using qRT-PCR in Iranian patients. The correlation between the linc00659 expression levels and clinicopathological features was assessed.Results Linc00659 was down-regulated in more GC samples compared to controls, but we found no significant association between the linc00659 expression levels and GC risk [expression ratio of linc00659 in tumor tissues versus non-tumor tissues was 0.57 (p = 0.33)]. After classifying patients into down−/up-regulation groups, a significant association was observed between the linc00659 expression and origin of the tumor (p = 0.01).Conclusion We found a significant association of the linc00659 expression with origin of the tumor. Further investigations with large sample size are required to assess the linc00659 function in tumor genesis.
WITHDRAWN: Hydrolyzed dyes as emerging environmental contaminants: household washing sources and electrochemical degradation
Authors: Zhao Xu , Hu Zhubing , Xu Yuyao , Liu Jianli , An Lihui , Wang Hongbo , Wang Yan , Zhu Bo , Tang Wei , Yang Qingbo , Yu Xi , Wang Ning , Mu Lingfeng
Published: April 2023

High-color saturation cotton fabrics dyed with reactive dyes often discharge hydrolyzed dyes during the washing process, resulting in dye transfer and water pollution because of the properties prone to hydrolysis of reactive dyes. To explore the sources of hydrolyzed dyes in the washing microenvironment, the hydrolysis experiment of pure reactive red 195 (RR195) and the washing experiment using some highly saturated colored fabrics (CFSCs) dyed with RR195 in a designed miniature washing device were carried out successively. Reversed-phase high-performance liquid chromatography (RP-HPLC) was used for the analysis of hydrolysis intermediates and final products of reactive red 195. The experimental results indicated that the structure of the dye shed on the fabric is consistent with the final hydrolysate of reactive red 195, which is the main colored contaminant in washing wastewater. To eliminate the hydrolyzed dyes from the source, an electrochemical degradation device was originally designed to degrade hydrolyzed dyes. The degradation parameters, including voltage, electrolyte concentration, and dye shedding concentration are discussed in the electrochemical degradation experiment. The electrochemical degradation device was also successfully implemented and verified in a home washing machine. The results showed that there were three hydrolysis intermediates and one final hydrolysate product in the hydrolysis process of RR195, and the washing and shedding of colored pollutants were the products of simultaneous hydrolysis of double reaction groups. The designed electrochemical degradation device can effectively eliminate the hydrolyzed reactive dyes and reduce the contaminants’ discharge during household washing.
Isolation, Identification and Characterization of α-cembratriene-4,6-diol Degrading Stenotrophomonas maltophilia H3-1 and Optimized Its Growth Parameters
Authors: Huang Shen , Hu Huibo , Qian Yumei , Manzoor Robina , Wang Qiuling , Shi Dongdong , Mao Duobin
Published: April 2023

Cembranoids compounds are mainly distributed in higher plants of the Pinaceae and Solanaceae families, as well as soft corals, and serve as important aroma precursors. Their degradation products are widely used in various aspects of life, such as farnesal, which finds extensive applications in the pharmaceutical industry. In this study, a strain (Stenotrophomonas maltophilia H3-1) was isolated from soil, which can efficiently degrade α-cedriene-4,6-diol.Based on GC-MS detection of α-cembratriene-4,6-diol degradation efficiency of the H3-1 strain, it was determined that the optimal culture conditions for H3-1 are 40°C, pH 8, maltose concentration of 2 g/L, and ammonium sulfate concentration of 2 g/L. Under the optimum culture conditions, the degradation rate of 1 mg/mL α-cembratriene-4,6-diol by H3-1 strain within 36 h was as high as 85.86%. This indicates the strong biodegradation ability of the H3-1 strain towards α-cembratriene-4,6-diol. Through GC-MS analysis, we identified the biodegradation products of α-cembratriene-4,6-diol, including farnesal. This provides a theoretical basis and microbial resources for further study on the degradation products and applications of α-cembratriene-4,6-diol.