bluuebunny/crossref_metadata_2025 huggingface dataset:
CONTEMPORARY DIMENSIONS OF LITERARY BORDERLAND MODELS
Authors:   Ukrainian-Polish high school “Central European University”, Sykhomlynov Oleksii
Published: December 2023

The geopolitical and social changes of the 20th century were the result of global cultural and aesthetic changes. The phenomenon of contemporary literature has become an extremely motley geography of “small homelands” and a kind of cultural federalism, occurring on various borderlands. In a globalised postmodern world, research and analysis of this phenomenon is of great importance. Despite the special interest in borderland literature among Polish and, more recently, Ukrainian scientists, the attention of researchers is usually focused on commonly known and popular artists of the 20th century, their literary works are rarely compared with the texts of other participants in the literary process. Despite this, the problem of functionality of ethnocultural models of Polish- Ukrainian borderland literature has never been the subject of a comprehensive analysis. Interest in border literature came in the 1990s. The heterogeneity and multidimensionality of the texts contributed to shaping the new mythology of the border, certain “kresomania”, and thus distortions and one-dimensionality in research. It was only at the beginning of the 21st century that the “frontier” discourse will acquire objective dimensions, and the neutral concept of “borderland” will be increasingly used in the study of this phenomenon, scientists from neighbouring countries (Ukraine, Lithuania, Belarus) will join the discussion. Cultural models of borderlands are characterised by a high level of relativity, cultural and linguistic interference that is caused by a common history, as well as the experience of living together in the common areas. Under these conditions, the formation of a common border ethnocultural model where the antinomy “center - periphery” category softened marginal areas.
THE WORD. ABOUT POETRY OF PROFESSOR HALINA KRUKOWSKA IN THE CONTEXT OF HISTORY OF BIAŁYSTOK CLUB OF CATHOLIC INTELLIGENCE
Authors:   University of Białystok, Kulesza Dariusz
Published: December 2023

The article contains an analysis and interpretation of several poems by professor Halina Krukowska, a literature expert who died in the summer of 2019 and one of those who created the Bialystok Polish Studies. The reading of the poems has been placed in the context of the mysticism of St. John of the Cross and St. Theresa of Jesus. It is accompanied by the history of the Bialystok Club of Catholic Intelligence, whose “Słowo” magazine professor Krukowska edited and published her popular science texts and poems reviewed in the article.
REFERENCE REPORTER’S VISIONS RICHARD KAPUŚCIŃSKI IN THE CONTEXT OF IDEAS OF GLOBAL GLOBALISATION AND CONTEMPORARY JOURNALISM DEVELOPMENT TRENDS
Authors:   National  technical  University  of  Ukraine  «KPI  them.  Igor  Sikorskyi», Yanishevskyi Oleksandr
Published: December 2023

Dialogue of cultures, dialogue of civilisations, dialogue of generations, intentionality of daily work of a journalist - this is what Kapuściński saw as the task of a reporter working outside his homeland. Because the pen worker who does the editorial work within the country is monopolarly tuned, that is, he cannot reflect the entire multi-vector of the globalised world because of the enormous pressure of the environment that he is experiencing. In another civilisational and cultural environment, the reporter is not connected by thousands of invisible threads to the environment (except purely formal ones), and he can claim a more or less objective perception of social reality without resorting to its reception. After trying to add his vision, commenting, the reporter becomes an analyst manipulator, acting for a specific purpose: personal (willing to speak) or ordered (so it is necessary, because someone wants it). Of course, no journalist, reporter, or other media worker wants the results of his work to create any kind of negative discourse in the society of a particular country, and more so in the whole region. But by resorting to manipulation, namely by actually usurping the knowledge of the world, the media man thus makes a wrong act for the sake of (in his view) the right thing to do.
WIESŁAW MYŚLIWSKI AS A PHILOSOPHER. LITERATURE CONSENSATIONS
Authors:   University of Białystok, Piętniewicz Michał
Published: December 2023

The author of the article presents Wiesław Myśliwski’s silhouette as a philosopher who, without using professional philosophical concepts and without using professional philosophical language, brings closer in his novels and dramas the basic philosophical categories such as life, death, meaning, the mystery of being, the mystery of identity. The article focuses on the most important opinions of the author of articles and monographs that explore this problem in a creative and insightful way. The aim of the article is to examine the philosophical contexts in which Wiesław Myśliwski’s writing is inscribed. The main conclusion of the article is that, although it is almost impossible to say that Myśliwski is a philosopher, one can get closer to this truth by examining carefully the language of the novels and dramas by th
Some biochemical characteristics of the hairy roots of Pisum sativum L. mutants
Authors: Timina Olga , Timin Oleg , Stepanova Anna
Published: December 2023

Two high-protein root cultures of vegetable pea mutants were received [1]. In continuation a PCR analysis of the obtained root cultures genes was carried out according [2] and the amino acid composition of the cultures protein was clarified in a dry product on the AAA 339TM device [3]. Obtained results confirmed the absence of rhizobia contamination of the cultures, which grow steadily on a hormone-free media for 5 years. PCR analysis revealed that fourrolgenesA,B,C,Dwere inserted into the genome of the root culture with genotypeafaftltl, and two —rol Candrol D— in the genome of the root culture with genotypetltl. The protein composition of the obtained cultures was represented by essential and non-essential amino acids and some others. In four inserts culture, the content of essential, ketogenic, proteinogenic and sulfur-containing amino acids prevailed by 1.5–2 times. Two inserts culture has twice as much aspartic acid and proline. Both cultures lacked tryptophan. The number of inserts determines the amino acid composition most likely.
Nearly Simultaneous Pairs and Triplets of Historical Destructive Earthquakes with Distant Epicenters in the Italian Apennines
Authors: Galli Paolo
Published: December 2023

Historical seismic catalogs of Italy record several instances of pairs or triplets of large earthquakes (Mw>6.7) along the Apennine chain, occurring on the same date or within a short time frame (days or weeks). Some of these events have mesoseismic areas tens of kilometers apart and/or seismogenic structures located more than 1–3 times the fault length away. Although in the case of aligned and/or contiguous faults, their cascading activation can be explained by variations in static Coulomb stress, in the case of distant faults, this mechanism could sometimes be replaced by what is known as dynamic triggering, which is caused by the passage of seismic waves generated by a remote source. In this study, I analyze three significant ancient seismic sequences that occurred in the south-central Apennines, suggesting that the extent of the destructive effects of these earthquakes can be attributed to remote dynamic triggering, causing the activation of different and unrelated seismogenic structures within a specific time frame.
How is Design Thinking Applied in Practice?
Authors:   , Cleveland Wade John , Andras Trina , Nag Rajiv
Published: December 2023

Design thinking is a problem-solving methodology and human centered innovation process which continues to enjoy increasing popularity with practitioners, business leaders, scholars, and educators for its potential to foster innovative activity across a wide array of business and organizational challenges. While vaulting to popularity in the wake of Tim Brown and IDEO's emergence in 2008 with a simplified and commercialized methodology, where everyone can be a designer, it also has its share of problems making it a challenging subject. First, there is no agreed upon definition for design thinking, and the term itself is a subject of controversy among its practitioners and advocates. Second, while design thinking has gained in popularity with its mass appeal, it has a rich history rooted in design theory which has allowed for the emergence of both managerial and "designerly" discourses resulting in a "dual discourse" problem. Third, design thinking cannot seem to shake its perception of being a management fad. This research studies how design thinking is applied in the field by practitioners by asking: Are all practitioners using design thinking in the same way? Are design thinking methodologies producing the expected outcomes? Are there new insights that may improve upon the current model(s) to better serve the end user, which are not captured in the literature? While this study does not attempt to arrive at a unified definition for design thinking, it does contextualize design thinking from the perspective of design thinking practitioners while developing a processual model describing how it is practiced. This model proposes four separate process pathways combining substantive, symbolic, choreographic, and educational actions. These actions all happen simultaneously, are seemingly interrelated and are all choreographed by the lead practitioner as if it were a theatrical production with numerous moving parts, interdependent on each other. Moreover, this study reveals additional outcomes beyond problem solving that practitioners arrive at which serve to improve business objectives and drive cultural change. Keywords: Design thinking, process model, process pathways, design thinking outcomes, symbolic actions, design thinking practice, design thinking application, business transformation, cultural change, grounded theory
Roselle Pest Detection and Classification Using Threshold and Template Matching
Authors: Bastian Ade , Nurzaman Adie Iman , Prasetyo Tri Ferga , Fatimah Sri
Published: December 2023

Roselle is a fiber-producing plant that has broad benefits for health food, so many farmers are interested in starting to cultivate it. This study aims to design a rosella plant pest detection system to reduce the risk of crop failure or reduced yields of rosella calyx. The design of a system for detecting and classifying rosella pests uses the threshold method as a digital image processing method connected via the internet with information media applications and template matching to detect and classify pests on rosella plants. Detection of pests on rosella plants has been successfully built using a detection system using thresholding and template matching methods. Datasets of rosella plant pests that are not yet widely available encourage the detection of rosella plant pests with datasets from rosella plant objects and limited data testing. Testing with 75% accuracy, the detection process is affected by light and camera quality.
An Enhanced Security in Medical Image Encryption Using Dynamic Chaotic Fuzzy Based Technique
Authors: Bhattacharjee Snehashish , Gupta Mousumi , Chatterjee Biswajoy
Published: December 2023

As IoT and cloud computing have grown in popularity, medical images are now often transmitted between devices or accessed directly from the cloud. With this, the security is always a concern as these images are prone to many types of attack. We have proposed a proven method that is efficient in terms of security, time complexity, and integrity in order to be cloud-friendly so that it may be launched into the cloud and made accessible to users at any time. The goal of the work is to create a dynamic key that, depending on fuzzy values, alters the reproduction rate parameters with each repetition. By applying the last chaotic value created from the previous iteration, the fuzzy triangular membership function has been used in this manner to generate the reproduction rate parameter. The uniqueness and major benefit of the suggested strategy are that it can increase the security of the algorithm that makes use of a chaotic map and a static key. The method has been put forth when designing algorithms so that it should not only demonstrate security against different attacks but also provide efficiency towards computational complexity. The technique has been tested against a set of images and an existing algorithm using a variety of security metrics, including the correlation coefficient, Number of Pixel Change Rate (NPCR), Unified Average Changing Intensity (UACI), and entropy. It has been determined from the comparative analysis that the proposed approach can make the existing algorithm more secure.
Evaluation of SSD Architecture for Small Size Object Detection: A Case Study on UAV Oil Pipeline MonitoringEvaluation of SSD Architecture for Small Size Object Detection: A Case Study on UAV Oil Pipeline Monitoring
Authors: Arrahmah Annisa Istiqomah , Rahmania Rissa , Saputra Dany Eka
Published: December 2023

Oil pipeline monitoring using Unmanned Airborne Vehicles (UAV) can be done by utilizing Deep Learning. Deep Learning can be used to automatically detect harmed or unauthorized objects near the pipeline for further action by the authority. Input video in the pipeline area taken from the UAV has unique characteristics. It has low resolution with dense composition object in the image. The detected object also has a small scale as the objects are far away from the UAV. Thus, the selection of the Deep Learning algorithm is important to get a desirable result with the following conditions. Single Shot Multi-Box (SSD) is one of the popular Deep Learning algorithms with fast calculation compared to others and suitable for real-time object detection. Previous works on this topic using low to medium altitude dataset (20–200 m). This paper provides an evaluation of SSD implementation to detect vehicles on high-altitude dataset (300 m). As much as 2482 dataset is fed into SSD architecture and trained to detect 3 class of vehicles. The result shows the mAP and mAR are 0.026360 and 0.067377, respectively. However, the low lost function value shows that the model is able to classify the object correctly. In conclusion, the SSD cannot process low density information to correctly locate the object.
A Study on the Role of Competency-Based Curriculum: Focusing on the 2015 and 2022 revised curricula
Authors:   The Korea Association of Yeolin Education, Kim YongMin
Published: December 2023

The purpose of this study is to examine how the concept of competency promoted by the OECD is reflected in the 2015 revised curriculum and the 2022 revised curriculum and whether there is continuity between them. This consideration is to examine the change in the role of competency that acts as a catalyst for creating new knowledge through utilizing knowledge depending on the situation. The research finds that the curriculum is evolving towards building a human model that nurtures democratic citizenship with an emphasis on compassion and responsibility, shifting from the pursued values and goals. As the concept of competency that appeared in the 2015 curricula has been expanded to the 2022 curricula, it was found to be linked to and continuous with OECD Education 2030. In the 2022 revised curricula, it can be said that this connection was further strengthened with the emergence of the student agency and transformational capabilities of OECD Education 2030. In OECD Education 2030, competencies are placed at the center of the learning compass, surrounded by core standards including knowledge, attitudes, skills, and values, suggesting an expansion of the concept of competencies beyond mere skill and knowledge acquisition. These changes were reflected in the 2022 revised curricula, and it can be said that the competency-oriented education area has been expanded
Trends in Research on Personalized and Customized Learning through Topic Modeling : A Comparison between Elementary, Secondary Education and Higher Eduacation levels
Authors:   The Korea Association of Yeolin Education, Park Jonghyang , An Hwasil
Published: December 2023

The purpose of this study is to analyze the trends in personalized & customized learning that considers learner-centered education, individual learner’s needs, learning styles and examines the similarities and differences between primary and secondary education and university level. Using topic modeling, 732 abstracts published in KCI and other journals until June 2023 were analyzed, resulting in six topics: “institutional aspects of school curriculum”, “factors related to ability and level-based instruction”, “digital systems and content”, “learner and instructional design for diverse groups”, “societal demands for desired qualities and competencies”, and “development and initiatives for improving/integrating teaching (learning difficulties, disabilities, inclusive classrooms)”. Depending on the volume of research, the time periods were divided into three cycles with research on topic 1, “institutional aspects of school curriculum”, and topic 5, “competencies required by society”, showing an increasing trend. Special education and educational studies were the main focus of research, with keywords related to learning difficulties and special education in primary and secondary levels, and competency-based education at the university level. Commonly, research related to personalized learning using digital systems and content was conducted in a similar volume. This study compared and analyzed macroscopic and microscopic aspects by reflecting the application of learner-centered curriculum at the time when educational policies were implemented. The study provides suggestions for addressing obstacles, issues, and further research in individualized personalized learning.
An Analysis of the Effect of Economic Education on Economic Knowledge of Early Childhood Teachers
Authors:   The Korea Association of Yeolin Education, Lee Jong-Hyang , Kim Seong Hyun
Published: December 2023

The purpose of this study was to examine how the experience of in-service teacher education related to economic education affects economic knowledge according to institutional type, teacher education type, and method for appropriate early childhood economic education. The subjects of this study were 256 early childhood teachers working in kindergartens and daycare centers located in G and T cities in Gyeongsangnam-do. To measure the economic understanding of early childhood teachers, the economic understanding test questions for schools from the Council on Economic Education (CEE) and the economic understanding test questions for elementary, middle, and high school students nationwide from the Korea Council for Economic Education (2013) are included in early childhood economic education. Economic concepts were extracted and constructed. The collected data were analyzed using the SPSS 21.0 program, and t-test and F-test were performed. As a result of the study, differences in understanding were found depending on the type of institution and training type, but no differences were found depending on the operation method. This study is significant in that it provides a teacher education plan to implement economic education for children in everyday life.
Difficulties in Academic Advising as Perceived by Faculty Advisors
Authors:   The Korea Association of Yeolin Education, Park Altteuri , Park Eunyoung , Jeon Sori
Published: December 2023

This study was conducted for the purpose of exploring the difficulties experienced in academic advising by professors participating in the responsible advisor system, a Faculty-Only Model. For this purpose, data was collected from nine professors working at K University and analyzed using concept-mapping research methods. The results are as follows. First, the perception of difficulties in academic advising was classified into two dimensions: ‘student characteristics’ - ‘academic advising system’, ‘non professors factors’ - ‘professors factors’. Second, there were six types of clusters of difficulties, and the order of importance of the types is as follows : “response to students who need linkage with counseling center”, “difficulties in providing appropriate intervention for students with various characteristics, including at-risk students”, “lack of systematic training and guidelines”, “students’ attitudes and readiness toward academic advising”, “helplessness felt by professors in areas where advice is needed.”, and “difficulties caused by the academic advice system and physical environment”. Based on the results, implications for the responsible advisor system were proposed.
Solutions to Political Problems and Their Meaning as Seen Through Editorials of Media Outlets
Authors:   The Korea Association of Yeolin Education, Yu Kyungha
Published: December 2023

This study divides past settlement into two types (criminal prosecution model - reconciliation model) and integrates the 5 principles of solving the “Gwangju problem” (punishment of responsible persons, compensation for victims, investigation of the truth, restoration of victims' honor, reconciliation and integration). pursuit) was analyzed. To this end, by analyzing 139 editorials of the Dong-A Ilbo, one of the major daily newspapers, from 1993 to 2022, it is diachronic how the tasks of liquidation of the May 18th over the past 30 years have been recorded and expressed through the ways and aspects of change. It was analyzed and evaluated from this point of view. As a result of the analysis, Dong-A Ilbo editorials related to the settlement of the past posted the most editorials related to truth finding among the 5 principles, followed by editorials on punishment of those responsible (perpetrators), followed by demands for restoration of the victim's honor, demand for compensation for victims, and reconciliation and integration. It was confirmed that the amount of publication was classified in the order of pursuit. It is interpreted as a reflection of the will that, in order to truly settle the past, first of all, it is essential to find out the truth and fair punishment for those responsible. In particular, the Dong-A Ilbo's editorials were identified as focusing on the original role of the media as a public communication medium rather than adhering to value-oriented discourses according to political tendencies regarding changes and trends that are receiving great attention both socially and politically. Through this analysis, this study aims to help our society and community reexamine the democratic and historical meaning of May 18 in the history of Korean democracy, gain knowledge about social issues that have arisen in the public sphere, and further increase awareness of the universal values pursued by human society. We wanted to provide a foundation for rediscovery. In addition, for this purpose, after the discourse analysis discussion process, the reasons for emphasizing the ‘necessity of democratic citizenship education’ were briefly presented.
Toward Localized Labor Rights Education: FGI Research with Elementary, Middle, and High School Teachers in Seoul
Authors:   The Korea Association of Yeolin Education, Choi Yoonjung
Published: December 2023

This study aims to explore localized, contextually-situated labor rights education in schools based on the perceptions and experiences of in-service teachers in the Seoul metropolitan area. This study, adopting FGI (Focus Group Interviews) with 9 elementary, middle, and high public school teachers who have expertise in labor rights education, sought to portray the direction of school labor rights education that reflects the specificity of Seoul's regional context and the local curriculum while also being universal, integrative, and inclusive in nature. The research results led to specific and practical suggestions from teachers in three dimensions: curricular contents, classroom practices, and policy support. First, the need for labor rights education in schools was emphasized, which reflects the multi-layered and variable industrial structure and types of work in Seoul, while considering regional diversity and polarization, and also focusing on timely and future-oriented social changes. Second, the effectiveness of real-life integrated, participatory, and issue-based inquiry methods was highlighted, emphasizing the importance of collaboration with the local communities and the integration of regional curriculum policies. Third, it was suggested that labor rights education content be included in professional development programs as mandatory while also supporting voluntary learning communities of educators to facilitate long-term vision and continuous practice. The research findings provide empirical evidence for labor rights education at the regional education levels in the future and offer insights into future implications.
A Theoretical Study and Meaning Study on General Trust and Related Effects: Focusing on Moral Subject Education
Authors:   The Korea Association of Yeolin Education, Kwak Youngkuen
Published: December 2023

This study aims to understand the general trust in moral trust, theoretically explore representative examples of effects related to it, and find meaning in moral education. To this end, this study attempted to identify degrees of trust in our society, recognize the necessity of research, and examine moral trust and general trust as the main concepts of trust. In addition, it was intended to understand the placebo and nocebo effects in life, Pygmalion effects in moral subject education, which were discovered through various prior studies related to trust, and to emphasize positive expectations through general trust. As a result, it was possible to confirm the importance of general trust along with moral trust, and to grasp the significance of the effect according to trust. In particular, it was possible to understand the justification of a conscious approach based on the general trust of teachers in moral subject education. In conclusion, general trust in moral education will make human life more enjoyable (placere), so it should be pursued consciously with interest.
Fuctional balancing in complete dentures- A case report revisiting the paterson’s technique
Authors: Pathiyil Varsha , Pathiyil Varsha , Preeti  , Richa  , Huda Irfanul
Published: December 2023

: A good occlusion is the key to the comfort and longevity of a prosthesis.

: This case report presents a 63 year old male patient who reported with the complaint of difficulty in chewing since past 3 months.

: On examination, the patient presented with completely edentulous upper and lower arch. A detailed case history was recorded followed by, primary and secondary impressions. The maxillo-mandibular relation was recorded conventionally on wax occlusal rims. A trough was then made in the wax and filled with a mixture of dental plaster and carborundum. The mix was kept 2mm above the plane. The rims were inserted and the patient was instructed to perform lateral and protrusive movements resulting in the incorporation of the compensating curves. The recorded plaster index served as a guide for the teeth arrangement. The denture was processed and delivered with very minimal need for post insertion corrections.

: According to Paterson (1923), an articulator with lateral movements is not necessary to establish a balanced occlusion when using the functional technique. The teeth arrangement is entirely dependent on the established curves for obtaining balance.

: Various techniques are cited throughout the literature to provide a successful prosthesis. With all the advances in the digital era, denture fabrication is not an automated procedure. It is pertinent that the clinicians master the fundamentals of prosthesis fabrication, without which any amount of technology and/or persistence might be in vain.
Fabrication of obturator using intraoral scanning impression technology: A clinical report
Authors: Gupta Gaurav , Gupta DK , Gupta Neelia , Gupta Priyanka , Chandra Neeraj , Rana Kuldeep Singh
Published: December 2023

This article presents a digital technique for the fabrication of surgical obturator for patient with decreased mouth opening planned for hemimaxillectomy. Here fabrication of obturator was done without conventional impression. Obturator was placed in position intra-orally post tumor resection to complete obturation. Procedure followed led to an accurate fit of the prosthesis.
Evaluation of variable doses of tachnid fly, Sturmiopsis inferens for the management of Sesamia inferens under field conditions in rice and wheat
Authors: Singh Gurpinder , Sharma Sudhendu
Published: December 2023

Evaluation of variable doses of tachnid fly, Sturmiopsis inferens for the management of pink stem borer, Sesamia inferens under field conditions in basmati rice (var. Pusa Basmati 1121) and wheat (var. HD 2967) was carried out at a farmer’s field in Ludhiana. Two intervals, i.e. one at 10 days and the other at 15 days were followed for releasing different doses (75, 100, 125 and 150 gravid females/ha) of S. inferens during August-October in rice and November-December in wheat. In case of Basmati rice, the minimum incidence of Sesamia inferens was recorded in treatment where a higher dose of 150 gravid females per ha was released (1.05 % DH at 75 DAT, 1.09 % WE), which was significantly at par with the dose of 125 gravid females per ha. The untreated control plot observed the highest incidence of Sesamia inferens (1.81% DH, 2.11% WE). The observations on grain yield revealed that higher doses of 125 and 150 per ha were significantly superior (37.90-38.41 q/ha) while doses of 100 and 75 per ha were at par with each other (36.35 and 36.91 q/ha, respectively) and minimum grain yield was recorded in untreated plots (34.73 q/ha). In the case of wheat, the minimum incidence was recorded in a treatment where a higher dose of 150 gravid females per ha was released (1.49% DH at 45 DAS, 1.28% WE), which was significantly at par with the dose of 125 gravid females per ha (1.66 % DH at 45 DAS, 1.50% WE). The untreated control plot observed the highest incidence (2.48 % DH at 45 DAS, 2.65% WE). The higher doses of 125 and 150 per ha were significantly superior in terms of grain yield (46.68-47.17 q/ha), while doses of 100 and 75 per ha gave a yield of 45.41 and 44.13 q/ha, respectively.
Exploitation of indigenous fluorescent pseudomonads for the management of wilt of chickpea caused by Fusarium oxysporum f. sp. ciceris
Authors: Sunkad Gururaj , Joshi Ranjana , Patil Meghana , Gour Akshatha
Published: December 2023

Chickpea wilt caused by Fusarium oxysporum f. sp. ciceris is a devastating soil-borne disease with a significant impact on yields and affecting chickpea production worldwide. Fluorescent pseudomonads are utilized as effective biocontrol agents (BCA) against a variety of phytopathogens and they play a key role in pathogen suppression through various processes. In the present study, twenty indigenous fluorescent pseudomonads were isolated from twenty soil samples collected from different districts of North Eastern Karnataka. The isolates were tested in vitro for their ability to resist the pathogen by using a dual culture approach. Further, morphological and biochemical characters were studied by growing these isolates on King’s B agar medium. All twenty isolates showed inhibition of the test pathogen, with isolate PF-19 showing the highest inhibition of 88.89%. All the isolates developed slimy, irregular colonies with light yellowish green pigmentation, fluorescence under UV light and rod-shaped cells under the microscope, as well as gram negative in reaction. All isolates except PF-2, Pf-9 and PF-10 revealed positive results for KOH, catalase, gelatin liquefaction and starch hydrolysis.
Intra- and inter-specific interactions between Coccinella transversalis and Cheilomenes sexmaculata in relation to prey abundance
Authors: Das R. , Devee A. M.
Published: December 2023

In the present study, we investigated the feeding rate and the effect of intra- and inter-specific interactions between adults, 3rd and 4th instar larvae of the coccinellids, Coccinella transversalis and Cheilomenes sexmaculata to its conspecific and heterospecific combinations under laboratory conditions. Cannibalism and the effect of interaction were investigated using the multiplicative risk model. Aphidophagous predators and their instars were kept alone, paired with conspecifics, and heterospecifics combinations in the absence and presence of prey (aphid, Aphis gossypii). In the presence of aphids, the combined release of these predator species revealed that except for (3rd × 3rd) and (4th× 4th) intraspecific combination of both predators, the observed consumption was lower than the expected consumption. In the case of interspecific combination, the observed consumption was significantly lower than expected and it indicated the antagonistic effect of both the predators in later instars in the presence of sufficient prey population. In the absence of the prey, intra-specific cannibalism was lowest between adults of both the species and highest among C. transversalis 3rd × C. transversalis adult and C. sexmaculata 3rd × C. sexmaculata adult. The interspecific predation was highest between C. transversalis adult × C. sexmaculata 3rd instar and lowest between adults of both species. The results suggest that C. transversalis was more a successful aphid predator, being able to find aphids more quickly and consume more of them compared to C. sexmaculata. As there was less intraspecific cannibalism among C. transversalis and individual consumption is also high, it is considered to play a significant role as a biocontrol agent in aphid management.
Species diversity of grasshoppers in Kamrup district of Assam and their management by aqueous extracts of Azadirachta indica A. Juss and Aegle marmelos L.
Authors: Dutta Uma , Dey Sonali
Published: December 2023

Grasshoppers pose a significant threat to agricultural productivity worldwide, causing substantial damage to various crops such as cereals, legumes, orchards, vegetables, grasslands, and forest plantations. This research aimed to study the species diversity of grasshoppers in five selected paddy field locations of Kamrup district, Assam, and assess the efficacy of aqueous extracts from the leaves of Azadirachta indica A. Juss (neem) and Aegle marmelos L. (bael) for controlling the most common grasshopper species, Acrida exaltata, found in the study locations. A total of 36 species of grasshoppers were collected and identified, out of which Acrididae was the most predominant grasshopper family, constituting 77.78% of the total collected species. The experimental results demonstrated abnormal changes in behaviour, including slower movement and increased inactivity among the aqueous extracts treated insects. Both the treated groups showed morphological and behavioural change with the more prominent effects observed from the neem-treated group. Haemolymph analysis revealed the presence of severe deformities in both treated groups, such as the spindle-shaped formation of cells, nuclear membrane disintegration, cell fusion and stacking, cytoplasmic vacuole formation, and cytoplasm degeneration. These findings demonstrate the pesticidal potential of neem and bael extracts against the Acrida exaltata grasshopper species, following its toxic impact on haematological, physiological, and morphological behaviour, suggesting the need for further research on their use as effective and environmentally friendly control measures against grasshopper pest infestations in densely vegetated and paddy fields in the region.
Exploring the impact of cyclic lipopeptides from Bacillus subtilis NBAIR-BSWG1 through in vitro and in planta, studies against Sclerotium rolfsii
Authors: Ankitha K. S. , Radha T. K. , Ruqiya S. , Kukreti Aditya , Aarthi N. , Nanditha S. , Rangeshwaran R. , Kandan A. , Sivakumar G. , Shylesha A. N. , Girisha H. C. , Nagaraju K. , Venkatesan T. , Sushil S. N. , Manjunatha C.
Published: December 2023

Bacillus subtilis is a Gram-positive bacterium known for its antagonistic attributes, particularly through the production of various secondary metabolites, including lipopeptides. In this study, we investigated the antagonistic capabilities of B. subtilis strain NBAIR-BSWG1 with a focus on assessing the efficacy of NBAIR-BSWG1 in combatting Sclerotium rolfsii. Our findings demonstrated substantial inhibitory effects, with 82.73% to 100% reduction in S. rolfsii growth when exposed to NBAIR-BSWG1 at concentrations ranging from 50 to 100 µL/mL in poison food technique. In dual culture assay, NBAIR-BSWG1 exhibited a significant 55.50% inhibition of S. rolfsii. Moreover, pot experiments revealed a promising 26% reduction in disease incidence. This study underscores the significant role of NBAIR-BSWG1 in controlling S. rolfsii, holding substantial potential for developing effective formulations aimed at mitigating the southern blight of tomatoes.
Od mutacji do leku
Authors: Wnuk Jan , Wilanowski Tomasz
Published: December 2023

Czerniak złośliwy to niebezpieczny rak skóry, odpowiadający za większość zgonów związanych z nowotworami skóry. U wielu pacjentów chorujących na tego raka, komórki nowotworowe posiadają mutację V600E w genie BRAF. Mutacja ta powoduje konstytutywną aktywację szlaku sygnałowego MAPK/ERK, przyczyniając się znacząco do procesu kancerogenezy. W niniejszym artykule został omówiony proces projektowania leków na przykładzie specyficznego inhibitora dla BRAF V600E, wemurafenibu. Na początku zaprezentowane są najczęściej stosowane metody projektowania leków. Druga część artykułu skupia się na wemurafenibie. Przedstawiony jest proces pierwszej syntezy tego inhibitora BRAF V600E oraz jego analogu i przebieg trzech etapów badań klinicznych. Na rynku wemurafenib jest sprzedawany w postaci leku Zelboraf. Dalej znajduje się opis innych popularnych leków na czerniaka złośliwego czyli dakarbazyny, ipilimumabu i dabrafenibu oraz krótka charakterystyka zalet terapii z równoczesnym zastosowaniem dwóch inhibitorów. Na końcu krótko omówiona jest rola sztucznej inteligencji w przyszłości projektowania leków.
Genotyping of Echinococcus granulosus Human Isolates Ob-tained from the Puncture, Aspiration, Injection, and Re-Aspiration (PAIR) Process in Türkiye
Authors: Akkaş Önder , Özgökçe Mesut , Aydemir Selahattin , Dündar İlyas , Ekici Abdurrahman
Published: December 2023

Background: Echinococcus granulosus is spread by the excretion of cystic organs into the environment. The dog is infected via eating the cystic organ. It then contaminates the environment with eggs of E. granulosus, which are infective to humans and animals. We aimed to determine the E. granulosus genotypes that cause infection in humans in the Van region, Türkiye.
Methods: Sixty patients between 18 and 100 years of age, who underwent the puncture, aspiration, injection, re-aspiration (PAIR) procedure in the Department of Radiodiognastics of Van Yüzüncü Yıl University, Van, Türkiye were included in the study. PAIR fluids were examined microscopically and DNA was isolated from the fluids. After DNA isolation, polymerase chain reaction (PCR) was performed using primers that amplify the E. granulosus NADH dehydrogenase subunit 1 (NAD1) gene region. After sequence analysis of the PCR amplicons, Basic Local Alignment Search Tool (BLAST) was performed.
Results: In the microscopic examination, protoscolex or hook was detected in 42 (70%) of the samples. DNA was successfully extracted from all of the cyst fluids containing protoscolex and hook, and the NAD1 gene region was PCR-amplified. After using BLAST, all of the samples were determined to be an E. granulosus sensu stricto G1 genotype. Sequence comparison revealed that four (9.5%) isolate sequences showed single nucleotide polymorphism (SNP). Sequences of isolates with SNP submitted to the GenBank with accession numbers OR565864 to OR565867. 
Conclusion: E. granulosus s.s. G1 genotype, known as sheep strain, is common in human hydatid disease in the Van region of Türkiye.
Comparison of Toxoplasmosis Seroprevalence in Multi Partner, Married (Monogamous) and Virgin Iranian Women
Authors: Shajarizadeh Mina , Biderouni Farid Tahvildar , Sohrabi Mohammad Reza , Abadi Alireza , Seyyedtabaei Seyyed Javad
Published: December 2023

Background: Toxoplasmosis could lead to serious outcomes during pregnancy. The aim of this study was to investigate serologic toxoplasmosis in three groups of women according to number of sexual partners.
Methods: The frequency of anti-Toxoplasma IgG from 471 women (101 virgin girls, 240 married women and 130 multi partner women) were determined by ELISA method from referred participant to medical centers of Tehran, Iran in 2020. The results were analyzed by chi-square and logistic regression tests.
Results: Prevalence of toxoplasmosis was significant with the number of sexual partner according to chi square test (P<0.001) and the highest one was observed in multi partners’ women (56.2%) and the lowest one in virgin girls (17.8%). ORs of virgin girls and multi partners’ women were 0.594 and 3.758 respectively, compared to married women. The effect of age on the frequency of anti-Toxoplasma IgG in married women was significant but it was not significant in multi partners’ women. In addition to IgG frequency in married women and multi partners’ women had no significant relationship with the number of children.
Conclusion: Having sexual activity after marriage and having multi partner in sexual activity may possibly be a novel risk factor for toxoplasmosis infection or increasing the IgG frequency.
Seroprevalence of Anti-Toxoplasma gondii Antibodies among Patients with Cancer at Hiwa Cancer Hospital in Sulaimani City, Kurdistan Region, Iraq
Authors: Mohammed Latif O. , Amin Ahmed MS , Mohammed Rezan M. , Mohammed Shad A. , Ahmed Lava I , Ahmed Vanya R. , Majid Shaz BD , Mohammed Bryar O
Published: December 2023

Background: Toxoplasma gondii is an opportunistic protozoan parasite that causes a life-threatening disease – toxoplasmosis – in immunocompromised individuals, including patients with cancer. This prospective cross-sectional study set out to determine the prevalence of toxoplasmosis in patients with cancer compared with that of healthy individuals.
Methods: A prospective cross-sectional study was conducted in Sulaimani City of Iraq from November 2019 to May 2020. Anti-T. gondii IgG and IgM antibodies were measured in the blood samples of 113 patients with cancer (80 with solid organ tumors and 33 with haematological malignancies) entered to Hiwa Cancer Hospital and 82 healthy controls, who were referred to the Directorate of Blood Transfusion for blood donation, using chemiluminescence microparticle immunoassay (CMIA).
Results: The prevalence of anti-T. gondii IgG was 39.8% in the patient group and 24.4% in the control group, which amounted to a significant difference (P = 0.024). Only one case of anti-T. gondii IgM positivity was observed in the patient group, and no IgM seropositivity was reported in the control group. Moreover, the seroprevalence of anti-T. gondii IgG was non-significantly higher (P = 0.102) in the patients with haematological malignancies (51.5%) than in those with solid organ tumors (35%). Occupation was the only risk factor which had a significant association with T gondii infection (odds ratio [OR]: 1.3, 95% confidence interval [CI]: 0.6746163 - 2.4282788, P = 0.029).
Conclusion: The prevalence of T. gondii infection is higher in patients with cancer than in healthy individuals. Therefore, T. gondii screening in patients with cancer is recommended.
A Cross Sectional Study of Coagulation Profile in Type 2 Diabetes Mellitus Patients in Correlation with HbA1c
Authors:   Department of General Medicine, Kumar Dr T. Arun
Published: December 2023

Introduction: Diabetes mellitus is a prevalent global health concern associated with increased cardiovascular risk. Hypercoagulability is a prominent feature in diabetic patients, contributing to thrombotic complications. This study explores the coagulation profile in Type 2 diabetes mellitus (T2DM) patients, focusing on the correlation with glycated hemoglobin (HbA1c). Aim: The study aims to assess coagulation impairment in T2DM through routine prothrombin time (PT) and activated partial thromboplastin time (APTT) measurements, thereby preventing thromboembolic cardiovascular disease (CVD). It further examines the relationship between coagulation parameters, HbA1c, and diabetes duration.
The Effect of Hyperhomocysteinemia, Low Serum Vitamin B12 and Folate on Increasing Lose of Bone Density and Increasing Incident of Osteoporotic Hip Fracture among Elderly Population
Authors:   Specialist Family Medicine, South Wakra Health Center, Department of Primary Healthcare (PHCC), Ministry of Public Health (MOPH), Al wakra city. Qatar, Tanash Dr Iyad Awad Yousef
Published: December 2023

Subjective: Many studies shown a relationship between high plasma homocysteine level, low serum vitamin B12 and folate level and increasing risk of loss bone mass density and the increasing risk of incidental hip fracture among the elderly population (age more than 65 years old in both sexes) Aim of the study: This systemic article review aims to revise the main researches related to this subject and find out whether there is a significant relationship between high plasma homocysteine level, low serum vitamin B12 and folate level and increasing risk of loss bone mass density and the increasing risk of incidental hip fracture among the elderly population (age more than 65 years old in both sexes) Methods: About 10retrospective and prospective (cohort) cross sectional related studies have been reviewed and analyzed for the purpose of reaching the results. High plasma homocysteine level (> 12μg/L), low serum vitamin B 12 level (< 200 μg/L)And low serum of vitamin B9(>140 μg/L) Discussion: Multiple medical and nutritional studies talk, discuss, and explain the relationship between high plasma homocysteine level, low serum vitamin B12 and folate level and increasing risk of loss bone mass density and the increasing risk of incidental hip fracture among the elderly population (age more than 65 years old in both sexes) Results: Most of the reviewed related researches have shown mild (weak) relationship between high plasma homocysteine level, low serum vitamin B12 and folate level, but this related researchhas shown mild significant relationship between high plasma homocysteine level, low serum vitamin B12 and folate and the increasing risk of incidental hip fracture. Keywords: Osteoporosis, Vitamin B12, Homocysteine, Folic Acid, Hip Fracture.