bluuebunny/crossref_metadata_2025 huggingface dataset:
Residential buildings in workers' villages in Latvia in the 1940s and 1970s. Example of brick buildings in the Jelgava area
Authors:   Latvia University of Life Sciences and Technologies, Latvia, Ziemeļniece Aija , Īle Una ,   Latvia University of Life Sciences and Technologies, Latvia
Published: February 2025

With the change of political power in Latvia after the Second World War, the country’s economy changed. The devastation of the war and the post-war period in the 1940s-1970s brought a new character to Latvia’s outer suburbs with workers’ villages consisting of apartment buildings with root gardens, barns and cellars. The workers’ villages in the suburbs, as well as the centres of kolkhozes or sovkhozes in the rural areas, began to implement new types of housing projects in the post-war years. The buildings in the workers’ villages connected with industrial production (wood processing, brickworks, sand pits, peat mines, stone crushing plants, dolomite quarries, etc.) formed their own spatial structure. However, with the wave of collectivisation in the 1940s/1950s and the development of collective farm/sovkhoz centres (MTS or machine and tractor stations, creameries, horse rental centres, seed etching centres, gatherers, sugar beet reception centres, grain dryers, wool carders, etc.), the spatial
structure of the built environment changed. The unifying aspect of the villages remained the subsistence farming character, where the residential area coexisted closely with the production area and the farm buildings - cattle sheds, pastures, hay sheds, wood shed, cellar, root garden, potato and fodder beet field. When the Latvian state’s economic policy changed in the 1990s, the transformation processes also affected the areas of the workers’ villages. Today, the character of post-war Soviet housing is still preserved and should be given the status of cultural heritage.
Política de avaliação da pós-graduação
Authors: Rossi Daiana Mendes de Oliveira , Alves Maria Michelle Fernandes , Rodrigues Camila Barros , Oliveira Breynner Ricardo de
Published: February 2025

No Brasil, a Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) é a agência federal responsável pelas diretrizes associadas à pós-graduação e à avaliação dos programas. A política de avaliação enfatiza a competitividade e a performance das instituições e dos pesquisadores, na medida em que condiciona o recurso financeiro aos resultados obtidos. Os professores e as instituições de ensino assumem a responsabilidade pelo sucesso ou fracasso de seus programas. Considerando a importância dos coordenadores dos programas para a implementação da política de avaliação da pós-graduação, este artigo analisa essa dinâmica e as práticas e estratégias adotadas por esses atores na Universidade Federal de Ouro Preto (UFOP). Os dados advêm de entrevistas realizadas com cinco coordenadores de programas de cinco áreas: (1) Ciências Humanas, Letras e Artes; (2) Ciências Exatas e da Terra; (3) Engenharias; (4) Ciências da Vida e (5) Ciências Sociais Aplicadas. As entrevistas abrangeram três dimensões: (i) Percepções sobre a Pós-Graduação no Brasil; (ii) Percepções sobre a Pós-Graduação na UFOP e (iii) Percepções sobre a Pós-Graduação no seu Programa e estratégias de atuação como Coordenador. As análises reforçam a tese de que há um processo de reconfiguração da educação superior pública. As entrevistas revelam que o condicionamento do financiamento à obtenção de resultados agrava a competição, a mercantilização do conhecimento, a precarização do trabalho docente e o adoecimento dos sujeitos envolvidos. A política fiscal recessiva tem reforçado o primado do orçamento sobre a função social da pós-graduação e da Universidade.
Antihypertensive drug amlodipine besylate shows potential in alleviating diabetic peripheral neuropathy
Authors: Wei Yuxi , Huang Yujie , Huang Runzhi , Ruan Yuan , Feng Tian , Zhou Fan , Zhang Wei , Lu Jianyu , Xie Sujie , Yao Yuntao , Wang Jiaying , Ji Shizhao , Shen Xu
Published: February 2025

Diabetic peripheral neuropathy (DPN) is a common diabetic complication with no currently available curative treatments. Here, we demonstrated that the protein level of G-protein-coupled receptor 40 (GPR40) is significantly repressed in the sciatic nerves (SN) of DPN patients, as well as in the peripheral nerves, including dorsal root ganglia (DRG) and SN, of streptozotocin (STZ)-induced type 1 diabetic mice and BKS Cg-m+/+Lepr db/J (db/db) type 2 diabetic mice. We identified that amlodipine besylate (AB), a first-line clinical antihypertensive drug, as a GPR40 agonist capable of alleviating DPN-like pathologies in mice. These pathologies include neurological damage, destruction of myelin sheath structures, vascular injury, loss of intraepidermal nerve fibers, and impaired neurite outgrowth in DRG neurons. To elucidate the underlying mechanisms, we generated the DPN mice with GPR40-specific knockdown in SN and DRG tissues using adeno associated virus 8-GPR40-RNAi. Mechanistically, AB attenuated inflammatory responses via the GPR40/β-arrestin2/NLRP3 pathway and ameliorated mitochondrial dysfunction through the GPR40/LKB1/AMPK/SIRT1/PGC-1α pathway in DPN mice, which were all further validated in primary human Schwann cells. Additionally, AB suppressed the crosstalk between Schwann cells and endothelial cells /DRG neurons in DPN mice. Collectively, our findings highlight the potential of AB for the treatment of DPN.
Preservation and Development of the Native Languages of Indigenous Minorities
Authors:   North-Eastern State University, Dorzheeva Victoria V. , Sleptsova Olga Yu. ,   North-Eastern State University, Stepanova Yulia G. ,   Institute for Humanities Research and Indigenous Studies of the North, Siberian Branch  of the Russian Academy of Sciences
Published: February 2025

The article delves into the analysis of data obtained through a sociological survey of the indigenous residents of a settlement that serves as the administrative center of a municipal district in the Magadan region, recog-nized as a traditional habitat and site for the customary economic activities of the indigenous minorities of the Russian Federation. National censuses have documented a decline in the population of indigenous minorities residing in the Magadan region, revealing a decrease in the number of speakers of the native languages of the Northern indigenous peoples. The issues of preservation, teaching, and transmission of minority languages have remained relevant over the past few decades. The urgent problem of maintaining traditional culture, na-tive languages, and the transmission of these values to the younger generation has become increasingly pro-nounced. The results of the survey indicated a loss of communicative functions of the native languages among indigenous peoples, both in everyday life and in broader social practices. It was found that the languages of indigenous peoples are no longer perceived as significant factors in the formation of a sense of belonging to their ethnic group. Furthermore, the survey documented the respondents’ expressed need for learning their native languages and their willingness to participate in efforts aimed at their preservation. This highlights a cru-cial aspect of cultural identity and the importance of linguistic heritage among indigenous communities.
History and Contemporaneity of Teaching Russian as a Foreign Language in Vietnam
Authors:   Lomonosov Moscow State University, Kashchuk Svetlana М. , Phung Thi Ngoc Anh ,   Moscow State Pedagogical University,   Vietnam National University of Ho Chi Minh City
Published: February 2025

The article presents the history of the emergence of the Russian language in Vietnam, the development of the practice of teaching it in schools and universities, and also shows the modern system of Vietnamese higher education in terms of the presence and functioning of its departments of training in the field of “Russian as a foreign language”. The aim of the article is to analyze the situation with the study of Russian as a foreign lan-guage in Vietnam. The authors identify the reasons for the decline in interest in studying Russian among Viet-namese students, and analyze the factors that contribute to stabilizing the situation in this regard and strength-ening the position of the Russian language in the political, economic and educational spheres of modern Viet-namese society. It is emphasized that the intensification of contacts between Russia and Vietnam in tourism, trade, political, diplomatic and other spheres of interaction is able to revive interest among the Vietnamese in Russian culture and language, returning it to the leading position among foreign linguistic systems studied in the country.
Art Pedagogy as a Means of Forming Motivation for Learning Activities in Primary School Children
Authors:   Tyumen State University, Savkina Natalia G. , Sheveleva Nadezhda P. ,   Tyumen Industrial University
Published: February 2025

The article investigates the role of art-pedagogy in fostering motivation for learning among primary school stu-dents. It provides a comprehensive definition of “art-pedagogy” and outlines its advantages. The study analyzes various organizational forms of work within this pedagogical framework. A set of classes using methods and forms of art-pedagogy aimed at correction and improvement of results, formation of learning motivation, achievement of success, increase of self-esteem, reduction of school anxiety is prepared and tested. Examples of exercises using the technology of art pedagogy in the process of extracurricular activities are given. Findings indicate that students in the experimental group, who participated in the proposed exercises, exhibited in-creased cognitive motivation and a greater willingness to meet academic expectations compared to their peers in the control group. Additionally, there was a notable rise in the levels of conscientiousness and responsibility among these students, as they became more inclined to adhere to the teacher’s instructions.
Normative-Legal Regulation of Types and Activities of Propaganda Subjects in Relation to Youth in the Russian Federation: Sociological Analysis
Authors:   Lomonosov Moscow State University, Dortseva Elena V.
Published: February 2025

The article delves into the sociological analysis of the normative-legal regulation concerning the types and ac-tivities of various subjects of propaganda in the Russian Federation. In the conditions of formation of electronic-digital civilization, global geopolitical redistribution of the world, as well as active information wars and battles, the relevance of this topic, from the point of view of ensuring the national security of the Russian Federation and countering the destructive activities of various subjects of propaganda, primarily in relation to the Russian youth, is beyond doubt. In the article, the author gradually moves from the concept of propaganda, to the description of various typologies of propaganda available in sociology, and then to the disclosure of the essence of the con-cepts of “constructive propaganda” and “destructive propaganda”. Then the author, systematizing the develop-ments in modern sociology on this issue, derives his own classification of subjects of constructive and destruc-tive propaganda, which is the novelty of this topic, especially in combination with the analysis of how the activi-ties of propaganda subjects are regulated in modern Russian legislation.
History of Interaction between Museums and the State
Authors:   Scientific Research Zoological Museum of the Lomonosov Moscow State University, Bigvava Arina S. ,   RUDN University
Published: February 2025

The article explores the origins and evolution of museums as social institutions, their functions in society and interaction with the state, starting from antiquity and ending with modernity. The author emphasizes that the need to preserve important information arose among mankind long before the appearance of languages and writing, and the first artifacts representing meaningful signs of communication date back to the IX millennium B.C. The article focuses on the fact that in different historical periods, states acted mainly as keepers of histori-cal artifacts, without showing active interest in their understanding and dissemination of information about them. However, over time and the development of science as an activity, the function of museums began to transform from a simple accumulation of information into knowledge bases. With the transition to post-industrial societies, museums are increasingly given the role of not only storing and demonstrating, but also actively producing knowledge. The article emphasizes that a modern museum should act as a “knowledge base”, which, in turn, requires active interaction with the state and society in order to fully perform these func-tions.
نظرية عند شاذلي فرحود في محتوى أغنية "القلب ومايهوى" إنشاد علي حجيج
Authors: Nuur Khaerun Nisa , Limpo Marwah , Sa’id Aely Yuliani , Nurfitriah Aqiilah
Published: February 2025

هذا البحث هو بحث الذي يستعرض إلى دراسة علم التركيب عن "محتوى أغنية "القلب ومايهوى" إنشاد علي حجيج )دراسة تحليلية تركيبية(. وتبين بها عن المعنى والعاطفة والخيال ولغة الشعر وموسيقى الشعر في أغنية "القلب وما يهوى" وعلاقة بين العناصر التركيبي في أغنية "القلب وما يهوى". الهدف الذي يراد عليه الحصول فيها هدفان: لمعرفة المعنى والعاطفة والخيال ولغة الشعر وموسيقى الشعر في أغنية "القلب وما يهوى" ولمعرفة علاقة بين العناصر في أغنية "القلب وما يهوى". وتتم طريقة الوصفي النوعي بطريقة الإستماع، وجمع الكتب والرسائل والمجلات المتعلقة بالبحوث، وتسجيل البيانات من المصادر التي تم جمعها. تظهر النتائج في هذا البحث يشير إلى أن أغنية "القلب ومايهوى" تتكون من 12 سطر باستخدام التحليل التركيبي لنظرية الشاذلي فرحود وتلك النظرية تتكون من 6 عناصر وهي المعنى والعاطفة والخيال ولغة الشعر وموسيقى الشعر وعلاقة بين العناصر التركيبي.
Linguistic Indecision. The Case Study of the SUPERlative
Authors: Sporiş Valerica
Published: February 2025

This research paper aims to identify and explain the ways in which the superlative comprising the prefixoid super- is spelled in current sports journalese. The absolute superlative renders the highest intensity of a quality, it has a non-comparative character ([+Intensity], [–Comparison]) and an increased productivity. I opted for the analysis of the language used in sports journalese, as this field is characterised by competition. In order to attract the readers’ attention, the journalists have the tendency to exaggerate and to this end they use intensifiers excessively. One of the ideas I started from in my research was to identify which terms, structures, pronunciations can or cannot be considered as deviations from the norm/mistakes. I will pay heed to the norms in force, as well as to the incontestable deviations from those norms. For this research I analysed contexts which comprise super as a prefixoid – an element which is used in the formation of a new word separated from the main word by a hyphen or linked to the main word, on the one hand, and super as a separate word, on the other hand. The analysis is based on a corpus which comprises articles containing words or structures with the element super. The articles in the corpus were retrieved from the website www.sport.ro® and they were published in the period January 1st - July 31st 2023. In this research I analysed the degree to which the rule regarding the spelling of compounds comprising prefixoids is respected in current sports journalese or whether there is a tendency of formal (semi-) autonomy of super as a means of expressing the absolute superlative. In order to obtain a clear picture of the linguistic phenomenon under scrutiny in this article I combined both modern and traditional methods of research.
The Controversies of “Feminine” Etiquette in Romanian Literature – Between Isolation and Belonging
Authors: Minculete Iunis
Published: February 2025

Gender stereotyping strongly impacted the evolution of Romanian women writers when they started to assert themselves in literature towards the end of the nineteenth century and in the first decades of the twentieth century. The scholars of that time used the term “feminine” to define women’s literary works, which contributed to widen the gap between them and their counterparts. Women’s literature was considered sentimental, instinctual, modest, and delicate, as its value was seen through the lens of their social roles. This paper aims to illustrate how the social stereotypes dictated the scholars’ approach to women’s literature and to highlight the controversies revolving around the use of the feminine as a coined term for their literary works.
Reintroduction of small game by hunters as an element of shaping biodiversity
Authors: Flis Marian , Rytlewski Grzegorz
Published: February 2025

This study addresses the issue of small game populations, which have shown a significant decline in numbers over the last decades. Populations of hares, pheasants and partridges are subject to hunting management by hunters in changing environmental and legal conditions. Hunting management of individual species based on the annual assessment of their numbers allows for optimizing management activities regarding decisions on shooting, limiting or suspending hunting, and possible reintroduction of animals in areas where populations are at risk. These activities also include planning and intensifying the fight against game predators, one of the critical ecosystem elements influencing the described species’ population dynamics. It should be noted that over the last decade, the involvement of hunters in the repopulation of natural ecosystems with small game has decreased. This is due both to economic factors related to the operation of hunting clubs and to increasing fees for hunting, as well as cyclical legal difficulties. Nevertheless, no group other than hunters has been undertaking and continuing the described initiatives for many years. However, on a smaller scale, they are perfectly in line with the protection and development of biodiversity.
Silent strike: stroke in context of endocarditis - brain imaging as a catalyst for diagnosis
Authors: Stoican Iulia-Cosmina , Dragoș Dorin , Papagheorghe Atena , Guberna Suzana Maria , Tuta Sorin , Manea Maria Mirabela
Published: February 2025

Introduction

Endocarditis is a pathology which is rarely encountered in clinical practice that presents itself in various manners, thus posing a great challenge for the clinician in the process of formulating a timely diagnosis, especially given its potentially lethal evolution. The diagnosis of infective endocarditis is based on Modified Duke Criteria. A wide array of complications may accompany endocarditis, including septic or thrombotic emboli to various territories – those occluding branches of cerebral arteries result in ischemic strokes, which may be demonstrated by brain imaging and the symptoms which may range from mild mental status alteration to deep coma. Objective: Assessment of brain imaging as a diagnostic tool for bacterial endocarditis.

Materials and methods

This is a nested case-control study, in which 84 patients with ischemic stroke were enrolled, half of them having endocarditis related stroke (cases), and the other half stroke due to cardioembolism from other sources or to large-artery atherosclerosis (controls).

Results

Brain imaging revealed statistically significant differences between the two cohorts, endocarditis related stroke being more strongly associated with multiple territories involvement, multiple lesions coexistence, watershed lesions, and a greater extent of ischemia all these may serve as valuable diagnostic clues. Among these findings, the presence of multiple lesions has been the most sensitive tool (Sn = 0.786, Sp = 0.857, LR+ = 5.497, LR− = 0.25), while the involvement of multiple arterial territories had the highest specificity and positive likelihood ratio for endocarditis-related stroke (Sn = 0.738, Sp = 0.929, LR+ = 10.394, LR− = 0.282). A larger ischemic lesion as quantified by pc-ASPECTS score (more than by the ASPECTS score) also increases the likelihood of endocarditis as the cause of ischemic stroke, with an AUROC of 0.7361 (95% CI 0.629–0.843).

Conclusions

Early brain imaging could play a crucial role in endocarditis, helping the clinician to suspect this diagnosis. Further studies are needed to understand the role of early brain imaging when Modified Duke Criteria fail to establish the diagnosis.
Choanal atresia: comprehensive review of diagnosis and management
Authors: Tanase Ionut , Lupoi Daniel , Coman Alexandru , Oprea Cristiana-Gratiela , Pascu Mihai Alexandru
Published: February 2025

Choanal atresia is a congenital condition characterized by the obstruction of the posterior nasal apertures. It can present as unilateral or bilateral and is associated with significant morbidity, particularly in neonates. This review provides a comprehensive overview of the diagnosis and management of choanal atresia. We discuss the epidemiology, etiology, and pathogenesis, emphasizing the developmental and genetic factors involved. Clinical presentation varies with age, and diagnosis typically involves a combination of clinical examination and imaging techniques. Management strategies have evolved, with a focus on surgical intervention. Various surgical techniques, including transnasal endoscopic and transpalatal approaches, are explored. Postoperative care and long-term outcomes are critical components of patient management. We also address current controversies in treatment and future directions for research. Understanding choanal atresia’s complexities is essential for improving patient outcomes and advancing therapeutic options.
The ability to determine the percentage of kidney contribution to excretory function. Preliminary results
Authors: Gromov A. I. , Domorovskaya Ya. S. , Sivkov A. V. , Prosyannikov M. Yu. , Voitko D. A. , Kaprin A. D. , Alekseev B. Ya. , Apolikhin O. I.
Published: February 2025

Purpose. Determination of the possibility of using kidney segmentation to obtain data on their volume and density characteristics to assess the split renal function.

Material and methods. The data of 31 patients who underwent nephroscintigraphy and CT examination of the kidneys with contrast were analyzed. Segmentation of both kidneys into the nephrographic phase of contrast was performed at the workstation using the Vitrea Advanced Visualization program. The obtained values of the volume were multiplied at the attenuation coefficient of X-ray radiation in Hounsfield units (HU) for each kidney to obtain the "mass" of the contrast preparation. Having divided the obtained value of each kidney by their sum value and multiplying by 100%, we obtained a split contribution of each kidney to their total excretory function in percentages. To verify the need to introduce parenchymal density into calculations in the native phase of the study, the density of the parenchyma of both kidneys was measured at three levels in the native phase, then, the calculated arithmetic mean was subtracted from the average density of the renal parenchyma in the nephrographic phase. Subsequently, the same calculations were performed to obtain the percentage contribution of the kidneys as before deducting the native density. Nephroscintigraphy was performed in various medical institutions. Studies were conducted with technetium compounds (99mTc). For further analysis, data on the percentage contribution of each kidney to their overall excretory function were taken.

Results. The obtained data on the percentage contribution of the kidneys to their total excretory function obtained by nephroscintigraphy were compared with the calculated CT data. The analysis showed a very high correlation and covariance of these results (the correlation coefficient is 0.99 (p < 0.001), the covariance coefficient is 0.95 (p < 0.001)). When conducting a correlation analysis of the results of nephroscintigraphy with CT data, where an additional correction was made for the native density of parenchyma (it was subtracted from the average density of parenchyma in the nephrographic phase), the results remained the same: the correlation coefficient was 0.99 (p < 0.001); the covariance coefficient was 0.95 (p < 0.001).

Conclusions. An accessible and practical method for evaluating split renal function has been developed. The method does not require the implementation of a clearly regulated time protocol for multiphase CT. CT data performed in any medical institution can be evaluated. The method does not require additional assessment of the native densitometric characteristics of the kidneys. The results obtained using the method showed a very high correlation with the data of dynamic nephroscintigraphy.
Redesain ekologis Kawasan Wisata Danau Sanggu Kabupaten Barito Selatan berbasis konsep waterfront
Authors: Agustina Gloria , Gunawan Andi , Hadi Akhmad Arifin
Published: February 2025

Sanggu Lake Tourism Area, located in South Barito Regency, Central Kalimantan, plays an important role in providing green open space for recreational and relaxation activities. The lack of management and changes in building orientation reduce the quality of the site and pose threats to environmental damage. Therefore it is necessary to redesign the waterfront area with an ecological approach to reduce environmental impact. The purpose of this research is to identify site character, analyze the potential and constraints on the site, to develop an ecological design concept, and to ecologically design the Sanggu Lake Tourism Area based on the waterfront concept. The stages of the research include the process of preparation, inventory, analysis and synthesis, and design. Collecting data through surveys, literature studies, interviews, and questionnaires. The basic concept of the research is "Ranu Welum" or Water of Life which is revealed to be 3 basic values, namely socio-cultural center, ecological park, and recreational waterfront. The design concept is taken from the typical Dayak motif, namely "Batang Garing" or the Tree of Life and implemented in spatial patterns, circulation, and vegetation. Ecological design is applied by implementing ecological principles based on community preferences. The results of the study are area redesign consisting of reception zones, tourist zones I, tourist zones II, relaxation zones, play zones, exercise zones, and service zones.
Kenyamanan Termal pada Kerapatan RTH yang Berbeda ditinjau dari Suhu Udara, Kelembapan Udara, Kecepatan Angin, dan Suhu Permukaan di Street Canyon, Jl. MH Thamrin, Jakarta Pusat
Authors: Tarigan Doksa Safira , Nasrullah Nizar , Sulistyantara Bambang
Published: February 2025

Jl. MH Thamrin is a street canyon area that is experiencing global warming, and has minimal vegetation to shade road users. This study aims to describe attributes of thermal comfort at Street Canyon, Jl. MH Thamrin at different green open space densities. Data collection was carried out by observing for 3 days using a thermohygrometer, anemometer data logger, DJI Thermal Drone, mini weather station. The collected air temperature and humidity data are analyzed by THI. The measurement results showed that air temperature data in non-dense area was higher than dense area, with a total average of 31,12°C and 30,27°C. It is different with the humidity which turns out to be more humid in dense areas (62,69%) than in non-dense areas (62,16%). This difference occurs because trees are able to reduce incoming sunlight thereby creating a humid atmosphere. The magnitude of the wind speed in dense areas is 1,41m/s, while for non-dense areas data is lower, namely 0,99 m/s. Surface temperature data is much hotter than air temperature. The lowest surface temperature in the non-dense area is around 26,95°C, while the highest surface temperature is 39,1°C. Likewise, the dense area segment has a maximum surface temperature of 33,9°C with a minimum surface temperature of 26,1°C. Furthermore, through the THI analysis it is known that the two segments are classified as uncomfortable. The highest THI is in non-dense areas 31°C, and 30,1°C in dense areas. It can be concluded that Street Canyon, Jl. MH Thamrin doesn’t have good thermal comfort in both areas.
The Association Between Preoperative Serum Thyroid-Stimulating Hormone and Neutrophil-Lymphocyte Ratio as Predictors of Papillary Thyroid Cancer
Authors: Stevenson William , Lumintang Nico , Tandililing Sherly , Wariki Windy Mariane
Published: February 2025

Aim: This study aims to evaluate the correlation between blood thyroid stimulating hormone levels and neutrophil lymphocyte ratio prior to thyroidectomy in patients with papillary thyroid cancer, as well as the potentiality of those as predictors of papillary thyroid cancer. Methods: Thyroid nodule patients over the age of 18 who received treatment at Prof. Dr. R.D. Kandou General Hospital between 2020 and 2024 and who fulfilled the requirements for research inclusion underwent thyroidectomy surgery. The study used a retrospective, descriptive-analytical strategy. Results: The association between TSHs and papillary thyroid cancer was significant with a p-value of 0.025, sensitivity of 51.1%, and specificity of 73.9%; the ROC analysis was performed for TSHs with the results of the AUC value analysis = 0.634 (95% CI: 0.518 – 0.749) with p value = 0.028; NLR and papillary thyroid cancer was significant with a p-value <0.001, sensitivity of 68.9%, and specificity of 100%; the ROC analysis was performed for NLR values with the results of the AUC analysis value = 0.852 (95% CI: 0.766-0.938) with p value = <0.001. Conclusion: NLR is advised as a better predictor of papillary thyroid cancer than TSHs.
Klasifikasi Penyakit Kardiovaskular Menggunakan Metode Fuzzy K-Nearest Neighbor (FKNN)
Authors: Cahyani Ni Komang Santi , Suhartana I Ketut Gede
Published: February 2025

Penyakit kardiovaskular merupakan penyakit tidak menular yang dapat menyebabkan kematian karena mengganggu fungsi jantung. Dalam hal ini, klasifikasi penyakit kardiovaskular dilakukan untuk memudahkan tenaga medis lainnya untuk membantu mendiagnosis penyakit kardiovaskular. Klasifikasi penyakit kardiovaskular menggunakan metode Fuzzy K-Nearest Neighbor (FKNN) untuk menentukan nilai tetangga terdekat yang optimal. Klasifikasi penyakit kardiovaskular dibagi menjadi dua, yaitu menderita penyakit kardiovaskular dan tidak menderita penyakit kardiovaskular. Hasil klasifikasi dengan menggunakan metode Fuzzy K-Nearest Neighbor (FKNN) dengan pengujian menggunakan confusion matrix menghasilkan akurasi sebesar 80,21% pada nilai K = 13 dan K = 15.
Authors: Wulandari Desak Putu Sri , Suhartana I Ketut Gede
Published: February 2025

Klasifikasi tingkat produktivitas pegawai garmen bertujuan untuk memudahkan perusahaan memberikan apresiasi kepada karyawan. Dalam melakukan klasifikasi tersebut, dapat menggunakan Algoritma Naïve Bayes, dimana algoritma ini menggunakan metode probabilitas dan statistik untuk memprediksi peluang berdasarkan pengalaman. Klasifikasi karyawan garmen dikategorikan menjadi tiga, yaitu rendah, sedang, dan tinggi. Hasil klasifikasi dari 1197 data pegawai, diperoleh 981 pegawai dengan produktivitas tinggi, 190 pegawai dengan produktivitas sedang, 26 pegawai dengan produktivitas rendah. Evaluasi pada klasifikasi diperoleh nilai akurasi sebesar 82,07% dengan nilai Root Mean Square Error (RMSE) sebesar 0,015731 yang menunjukkan bahwa klasifikasi yang dilakukan memiliki model klasifikasi yang baik.
Authors: Krisnayana Nyoman , Astuti Luh Gede
Published: February 2025

Salah satu alasan pengembangan desain aplikasi berbasis digital adalah untuk memecahkan masalah tertentu yang dialami oleh pengguna. Dalam perkembangannya diperlukan beberapa tahapan dan proses yang secara langsung melibatkan calon pengguna. Keterlibatan bertujuan untuk mengetahui kebutuhan dan harapan pengguna dalam memecahkan suatu masalah. Salah satu metode untuk mengetahui tingkat kebutuhan pengguna adalah metode usability testing. Pengujian usability melibatkan penguji dan partisipan. Penguji akan meminta partisipan untuk melakukan sejumlah tugas. Saat peserta melakukan sejumlah tugas, penguji akan mengamati behavior dan mendengarkan feedback selama pengujian berlangsung. Dalam hal ini dilakukan pengujian usability pada perancangan aplikasi e-commerce berbasis mobile bernama Ez Buy. Tujuan dari usability testing pada prototype aplikasi Ez Buy adalah untuk mengetahui sejauh mana user experience dan ekspektasi pengguna terhadap desain prototype aplikasi. Penelitian ini bertujuan untuk mengetahui perilaku partisipan terhadap sebuah fitur dalam prototype aplikasi.
Sumudu A domian Decomposition Method for Solving SEIVR Epidemic Model
Authors: Joudha Zainab Mohammed , Al-Azzawi Saad N. Ali
Published: February 2025

In this paper, we modify an SEIVR model concerning COVID-19 from the first-order system into a multi-fractional order system of differential equations. We also find an approximate solution by using the Sumudu Adomian decomposition method. Furthermore, we try to give qualitative results rather than qualitative results. Numerical simulation is given through a table and graphs which show the efficiency of the method.
Oscillation and Convergence of Solutions of Second Order Neutral Differential Equations with Periodic Coefficients
Authors: Neghmish Adyar Kamel , Mohamad Hussain Ali
Published: February 2025

This research aims to study the behavior of solutions of second-order neutral differential equations with periodic coefficients. Some necessary and sufficient conditions have been obtained that classify all solutions of these equations into three categories: either oscillatory, non-oscillatory, and convergent to zero, or non-oscillatory and divergent. The extent to which periodic coefficients influence the occurrence of oscillation, convergence, or divergence for each solution has been explained. The equation under consideration contained a variable delay and a constant delays in which the coefficients are periodic. Not much previous research has discussed the oscillation of solutions of second-order neutral equations with periodic coefficients.  In each case, some illustrative examples have been provided that illustrate the ease of achieving the conditions for the obtained results.
Robust Pedestrian Detection and Tracking Using CNN and SORT Algorithms
Authors: Abd-Alamir Tuqa Hani , Hathal Mohammed Sadoon
Published: February 2025

In recent years, there has been a growing popularity of autonomous vehicles due to their significant impact on society. One of the key tasks of autonomous vehicles is accurate pedestrian detection, which plays a vital role in preventing accidents. However, accurately detecting and tracking pedestrians under various environmental circumstances poses a significant challenge. In this paper, an efficient model for pedestrian detection is proposed by integrating three modules: You Only Look Once version 8 (YOLOv8) for object segmentation, Histogram of Oriented Gradients (HOG) for feature extraction, and Custom Convolutional Neural Network (CNN) for classification and detection. For tracking purposes, a simple online and real-time tracking (SORT) algorithm is used to track pedestrians in consecutive frames. Extensive experiments were conducted using the EPFL dataset. By leveraging the strengths of these modules, the proposed model aims to improve the accuracy and performance of pedestrian detection and tracking. The experimental results demonstrate the remarkable capability of the suggested model to detect and track pedestrians, achieving an accuracy rate of 93.34% even in challenging weather scenes.
Application of a Vegetation Health Index to Identify Distribution of Agricultural Drought in Diyala Province, Iraq
Authors: Ahmed Bushra A. , Hadid Rana S.
Published: February 2025

Over two decades, this study analyzes drought trends in Diyala Province, Iraq, and It utilizes remote sensing data and rainfall analysis to evaluate the severity and frequency of drought in 2002, 2005, 2010, 2015, 2020, and 2022. The research maps drought distributions in Diyala Province using satellite images from Landsat 7, Landsat 8, and Landsat 9 and analyzes the vegetation health index (VHI), soil moisture index (SMI), and average rainfall data. Results showed increased drought intensity: severe drought expanded from 48% in 2005 to 50% in 2022, and arid conditions increased from 1.1% in 2002 to 17.1% in 2022, as per SMI. Moreover, rainfall analysis reveals varying patterns, with 2022 experiencing lower average rainfall (4.215 mm) and higher variability (1.4633 mm standard deviation) compared to 2015 (6.735 mm, 1.1227 mm). The discoveries, pivotal for agriculture and water management, underscore the necessity of consistent monitoring and adaptable strategies for addressing shifting climate patterns.
Impact of Peganin Alkaloids from Harmala Plant as Inhibitor for Hyaluronidase Enzyme Produced by Staphylococcus Bacteria
Authors: Fayyad Sara , Majeed Majid
Published: February 2025

Hyaluronidase is an enzyme that primarily breaks down hyaluronic acid, thereby disrupting the structural integrity of the extracellular matrix (ECM) found in connective tissues, which is considered a virulence factor. Peganum is a genus of plants in the family Nitrariaceae that contains a number of alkaloids, including harmaline and harmine, which have been used in traditional medicine. This study aimed to investigate the effect of a plant-active compound (peganin) isolated from a plant sample as an inhibitor of hyaluronidase. In total, 120 samples were randomly isolated from infected burns. Isolates with highly hydrolyzed zones were identified. The Turbidity Reduction Assay was used to assess cell growth and hyaluronidase activity spectrophotometrically. The results showed that (100) out of 120 clinical samples grew bacteria when cultured on a blood agar medium. Also, it was discovered that, out of the 100 isolates, 56 (56%) belonged to S. aureus and had an inhibitory zone of Hyaluronidase range of 5-26mm; the inhibitory zone was increasing over time.
In vitro and Molecular Study of Synergistic Impact of Eugenol and Fosfomycin against Clinically-isolated, Fosfomycin-Resistant Escherichia coli
Authors: Ibrahim Ali Attaallah , Mohammed Rana Kadhim
Published: February 2025

Antibiotic resistance is a significant problem for which new treatments are required. There is growing concern about Fosfomycin resistance in Escherichia coli; understanding this resistance will help develop effective treatment strategies and preserve the efficacy of antibiotics. This study aimed to investigate the synergistic effects of Eugenol and Fosfomycin against Uropathogenic Escherichia coli (UPEC) and their possible potential as co-treatment. This study identified and isolated UPEC isolates from urine samples, with 63.6% being identified as UPEC. Antibiotic susceptibility tests showed that 99.3% of the UPEC isolates were resistant to multiple types of antibiotics [multidrug-resistant (MDR)]. The study examined the antibacterial properties of Fosfomycin and Eugenol using the parameters of agar well diffusion, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), fractional inhibitory concentration index (FICI), and time-kill curves. The MIC for Fosfomycin was 512-1024 µg/mL and for Eugenol was 1.25-5 µg/mL, while the MBC for Eugenol was 5-10 µg/mL and for Fosfomycin was 2048 µg/mL. Synergistic effects were considerable, where the addition of Eugenol at 1/4 MIC concentration resulted in 1/8 MIC of Fosfomycin. . The highest bactericidal activity for most UPEC isolates was recorded at 4-8 hours using Eugenol, 8-12 hours using Fosfomycin, and  4-8 hours using co-treatment. The study also used molecular assays to identify the expression levels of Fosfomycin resistance genes (murA, glpT, and cyaA) under different treatments, which revealed positive espression in all the isolates. The results showed variable gene expression changes in response to the different treatments. In conclusion, this study shows that Eugenol and Fosfomycin co-treatment is effective against UPEC.
Purification of Aqueous Solutions from Chromium Using Glass Sand
Authors: Mohammed Mohammed I. , Awadh Salih M.
Published: February 2025

This study aims to determine the ability of glass sand to absorb chromium from aqueous solutions. Glass sand samples were collected from the Rutba Formation (Cenomanian age) in the Western Desert of Iraq. Numerous laboratory experiments were conducted to test the effects of time and concentration on adsorption. For a duration of 5, 10, 15, 20, 25, 30, 35, 40, 45, and 50 minutes, four initial chromium concentrations (20, 40, 60, and 80) were tested. Glass sand to chromium solution ratio was 2 grams to 30 ml. Total dissolved solids (TDS), electrical conductivity (EC), and pH values were measured at 30ºC. The equilibrium time is determined as 20 min in most concentrations. The equation of Freundlich showed that the adsorption intensity (n) is equal to 0.0603, the constant of the Freundlich equation (Kf) = 59.06, Langmuir equation showed the sorption capacity (Qo) equivalent to 1.0989 mg/g, (KL) is 0.0487. The absorption of chromium was modelled using both the Langmuir and Freundlich equations. It was discovered that glass sand had the highest efficiency in chromium adsorption for solutions with a concentration of 20, reaching 74.54, and clarified how glass sand material could benefit from reducing the chromium concentrations from aqueous solutions protecting the environment.
The Effects of the Ukraine-Russia War on the Problem of Energy Resources and Agricultural Products Reflections on World and Türkiye Trade
Authors: Bulut Remzi
Published: February 2025

The Soviet Union, which had underground and surface riches, disintegrated at the end of 1991. 15 republics within the Union gained their independence. However, disagreements arose among some newly independent republics in terms of ethnic structure and borders. One of these is the escalation of tensions between Ukraine and Russia into a war. The war between the two countries has negative effects on global and Türkiye trade, especially on the region and developed European countries. The aim of this study is to analyse the impact of the war between Ukraine and Russia on energy resources and agricultural product imports of the world and European countries as well as Turkey. In the study, it is seen that Ukraine and Russia have significant shares in the world energy resources and agricultural products exports. In particular, it has been found that European Union countries and Türkiye are dependent on Russia in terms of energy resources, while Ukraine is dependent on Ukraine in terms of agricultural products. In addition, the war between the two countries has negative repercussions on the world and Türkiye economies.
ASSESSMENT OF THE IMPACT OF LOW-MOLECULAR-WEIGHT NATURAL COMPOUNDS FROM THE BAIKAL OXIPHILIC STRAIN JANTHINOBACTERIUM SP. ON MALE GAMETES
Authors:   Irkutsk State University, Shelkovnikova V.N. , Dmitrieva M.E. , Batalova A.A. , Belyshenko A.Yu. , Listopad A.S. , Axenov-Gribanov D.V.
Published: February 2025

The experiment assessed the impact of an extract from the Baikal oxiphilic strain Janthinobacterium sp. on human spermatozoa.
It was found that the diluted extract and some tested fractions had a stimulating effect on the spermatozoa, which could be useful in the
development of drugs to enhance their activity.
INVESTIGATION OF THE STABILITY OF EREMOMYCIN IN CULTURE FLUID AT VARIOUS TEMPERATURE AND PH CONDITIONS
Authors:   Russian Biotechnological University, Moscow, Shibaeva A.S. ,   All-Russian Research Institute of Phytopathology, Moscow, Glagoleva E.V. , Voinova T.M. , Djavakhia V.V.
Published: February 2025

The stability of eremomycin in the culture fluid of the strain Amycolatopsis orientalis was investigated during storage under
ambient and low temperatures as well as under various pH conditions. The findings provide insights into the ideal storage parameters
for maintaining integrity of eremomycin within the culture fluid.
DEVELOPMENT OF TECHNOLOGY FOR THE ANALYSIS OF BACTERIAL PATHOGENS ON “BRUSH” BIOCHIPS BY SOLID-PHASE MULTIPLEX PCR
Authors:   Engelhardt Institute of Molecular Biology RAS, Moscow, Shishkin I.Yu. , Sinnikov K.A. , Chirkova P.A. , Lapa S.A. , Chudinov A.V.
Published: February 2025

A matrix of hydrogel cells containing polymer “brushes” with active groups was obtained by photolithography on polymer
substrates. Covalent immobilization of reverse primers specific to Staphylococcus aureus or Legionella pneumophila into the corresponding cells was performed, followed by amplification in a sealed chamber of the assembled biochips.
PRODUCTION OF RECOMBINANT KERATINASE IN THE PRODUCER BACILLUS MOJAVENSIS
Authors:   Altai State University, Barnaul, Yakusheva E.A. , Sharlaeva E.A. , Kolosov P.V. , Scherbakov D.N. ,   State Research Center of Virology and Biotechnology “Vector”, Koltsovo
Published: February 2025

Due to the growth of animal husbandry in the world, the amount of keratin waste, which is a protein concentrate, is increasing.
Keratinases are enzymes that break down keratin. According to various studies, they have potential applications in various fields (leather production, detergents, pharmaceuticals and biomedicine).
STUDY OF RADIOMITIGATOR PROPERTIES OF MYOTIVE
Authors:   Institute of Theoretical and Experimental Biophysics RAS, Pushchino, Bykov A.S. ,   Tomsk State University,   Obninsk Institute for Nuclear Power Engineering —Branch of National Research Nuclear University MEPhI,   Emulsions Medical LLC, Serpukhov,   Institute of Cell Biophysics RAS, Pushchino, Molchanov S.G. , Yegorov A.Y. , Koryakin S.N. , Arshintseva E.V. , Pushkin S.Y. , Teplova P.O. , Timchenko M.A.
Published: February 2025

It is known that NMR spectroscopy can be effectively used to detect metabolic changes in the blood and urine caused by partial
and total body irradiation [1]. The purpose of our work was to study changes in the composition of metabolites of erythrocytes by NMR
spectroscopy after administration of the drug MYOTIVE to rats irradiated with γ-radiation at a dose corresponding to LD 50/30, and
to evaluate the radiomitigating properties of the drug.
Seleção de medicamentos da atenção secundária no estado do Ceará
Authors: Paiva Felipe Moreira de , Souza Nívia Tavares Pessoa de , Sales Neto Manoel Ribeiro de Albuquerque , Albuquerque Junior Ari Arcilio Carneiro Sales de , Gondim Ana Paula Soares
Published: February 2025

Objetivo: Analisar os documentos oficiais públicos referentes ao processo de seleção de medicamentos destinados à cobertura da atenção secundária em saúde do estado do Ceará. Métodos: Pesquisa documental das resoluções aprovadas pela Comissão Intergestores Bipartite do estado do Ceará, lançadas entre os anos de 2009 e 2023, no qual se analisou aspectos de evolução dos marcos regulatórios do elenco de medicamentos de acordo com as informações declaradas nas resoluções à luz da análise de conteúdo. Resultados: Identificamos seguintes unidades de análise: documentos públicos federais, documentos públicos estaduais e outras justificativas das ações de assistência farmacêutica. Outros parâmetros de avaliação de seleção de medicamentos identificados: presença de Comissão de Farmácia e Terapêutica, saúde baseada em evidências, estudos fármaco-econômicos, aspectos de assistência farmacêutica, indicação de alterações no elenco e uso da Relação Nacional de Medicamentos Essenciais. As resoluções demonstram que a seleção dos medicamentos ora contempla e ora não alguns aspectos importantes para esse processo, tornando-o não padronizado e não reprodutível. Conclusão: A adoção de estratégias para padronização da seleção de medicamentos, de acordo com o que indica a literatura científica vigente, poderia torná-lo mais robusto e seguro para seleção de medicamentos para o estado.