bluuebunny/crossref_metadata_2025 huggingface dataset:
Intravesical injections of triamcynolone and bladder hydrodistension in the treatment of patients with primary bladder pain syndrome.
Authors:   Research Center of Urology of Research Institute for Surgery and Emergency Medicine, Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of the Russian Federation, Slesarevskaya M.N. ,   Saint-Petersburg, Russia, Kuzmin I.V. ,   Urology Department of Academician I.P. Pavlov First Saint-Petersburg State Medical University of the Ministry of Healthcare of the Russian Federation; Saint-Petersburg, Russia, Ignashov Yu.A. ,   Urology Department of Academician I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Healthcare of the Russian Federation; Saint-Petersburg, Russia
Published: February 2024

Introduction. Primary bladder pain syndrome (PBPS) is important in urology, due to its high prevalence, negative impact on the quality of life of patients, as well as the lack of effectiveness of existing treatment strategies. The aim of the study was to compare the effectiveness of hydrodistension of the bladder (HD) in combination with intravesical injections of triamcinolone in patients with non-ulcer forms of PBPS. Materials and Methods. In this study participated 68 women with PBPS in the age 38 to 74 years (mean 53.7±9.4 years) were treated and divided into two groups. Patients of the 1st group (n=35) underwent HD in combination with intravesical injections of triamcinolone (in 30 points, 4 mg in 0.5 ml of saline per point, total dose 120 mg). Patients of the 2nd group (n=33) underwent only HD. Treatment efficacy was assessed in 1 and 3 months after the procedure. Results and discussion. One month after treatment a positive effect was observed in 30 (85.7%) patients of the 1st group and 22 (66.7%) patients of the 2nd group. After 3 months of treatment in the 1st group the improvement compared to the baseline remained in 28 (80%) patients and in the 2nd group only in 5 (15.2%) patients. The severity of symptoms in patients of the 1st group during these periods was significantly less than before treatment and also than in patients of the 2nd group. Tolerability of treatment in patients of both groups was good, no side effects were observed in any case. Conclusion. The results of the study indicate the efficacy and good tolerability of the combination of HD and intravesical injections of triamcinolone in patients with non-ulcer forms of PBPS. The therapeutic effect of the combined use of HD and triamcinolone was more pronounced and prolonged than after performing only HD.
The influence of urinary system pathology on the development of endometritis after cesarean section.
Authors:   the Department of Obstetrics and Gynecology of the Federal State Educational Institution of Higher Education North-Western State Medical University named after. I.I. Mechnikov of the Russian Ministry of Health. Chief freelance specialist in obstetrics and gynecology of the Leningrad Region Health Committee, Korobkov N.A. ,   Saint-Petersburg, Russia, Iglovikov N.Yu. ,   urology department of the Military Medical Academy S. M. Kirov; Saint-Petersburg, Russia, Protoshchak V.V. ,   the urology department of the Military Medical Academy S. M. Kirov; Saint-Petersburg, Russia, Babkin P.A. ,   urology department of the Military Medical Academy S.M. Kirov; Saint-Petersburg, Russia, Popov S.I. ,   the 1st therapy department for physicians postgraduation Military Medical Academy S. M. Kirov; Saint-Petersburg, Russia
Published: February 2024

Introduction. Pregnant women with pathology of the urinary system are at high risk of complications. The aim of the study was to assess the prevalence and structure of diseases of the urinary system in maternity women with endometritis after cesarean section, to determine their prognostic value as independent predictors of the development of postoperative infectious and inflammatory complications. Materials and methods. A retrospective multicenter statistical analysis of the medical histories and primary medical documentation data of 648 women delivered by caesarean section, 406 of them with a diagnosis of "endometritis after cesarean section" (main group) and 242 with the physiological course of the postoperative period (control group). Results and discussion. The prevalence of diseases of the urinary system in puerperant with endometritis was 56.5% and is mainly represented by urinary tract infection. Asymptomatic bacteriuria complicates the course of pregnancy 3.3 times more often in women with endometritis after cesarean section compared with the corresponding indicator in women with uncomplicated course of the postoperative period (20.9% vs. 6.3%), which makes it possible to attribute it to significant predictors of the development of postoperative infectious and inflammatory complications in obstetrics. Conclusion. According to the results of multivariate regression analysis, chronic and gestational pyelonephritis had less pronounced associations with the prediction of endometritis development after cesarean section.
Sterilization of single-use flexible ureteroscopes: myths and reality.
Authors:   urological department of Saint Petersburg State University Hospital, Associate Professor of the Department of Hospital Surgery SPbU, Gorgotsky I.A. ,   Saint-Petersburg, Russia, Aloyan A.A. ,   urological department of Saint Petersburg State University Hospital; Saint-Petersburg, Russia, Shkarupa A.A. ,   S.M. Kirov Military Medical Academy. S.M. Kirov; Saint-Petersburg, Russia, Martov A.G. ,   the Russian Academy of Sciences, Head of the Department of Urology and Andrology, Biomedical University of Innovation and continuing education A. I. Burnasyan Federal Medical Biophysical Center; Lomonosov Moscow State University Medical Research and Educational Center; Moscow, Russia, Petrov A.D. ,   urological department of Saint Petersburg State University Hospital; Saint-Petersburg, Russia, Konev S.D. ,   epidemiology department, epidemiologist of Saint Petersburg State University Hospital, postgraduate student of the epidemiology department of North-Western State Medical University n.a. I.I. Mechnikov; Saint-Petersburg, Russia, Kulyash A.G. ,   the molecular-biological laboratory of Saint Petersburg State University Hospital; Saint-Petersburg, Russia, Shkarupa D.D. ,   Saint Petersburg State University Hospital; Saint-Petersburg, Russia, Gadzhiev N.K. ,   Saint Petersburg State University Hospital, Professor of the Department of Hospital Surgery of SPbU; Saint-Petersburg, Russia
Published: February 2024

Introduction. Retrograde flexible ureteroscopy is the most safe and effective method of treatment of patients with kidney stones and urothelial tumors. Since 2017, disposable flexible ureteroscopes (URS) have been introduced into clinical practice. Single use scopes are equal in visualization and usability to reusable ones, and there is no need for complex maintenance. However, the cost of disposable endoscopes remains relatively high for clinics in developing countries, prompting many specialists to sterilize the disposable device and then reuse it again. Materials and Methods. Seven disposable flexible URS, after bi- and unilateral ureteropyeloscopy were sterilized according to the standard for reusable instruments immediately after surgery. After a complete sterilization cycle, samples were taken from various surfaces (insertion part, handle, control lever, port of the working channel, port of the irrigation channel, flush from the working channel) for bacteriological investigation. Results. Bacterial growth was detected on all flexible URS included in the study. All detected bacterial species belonged to the cutaneous bacterial microflora. The most frequently contaminated parts of the endoscope were the handle (n=4), the control lever (n=3) and the outer surface of the inserted part of the endoscope (n=2). Conclusions. Every single-use flexible URS that underwent a complete sterilization cycle was found to be contaminated with bacteria. Despite the technical feasibility, reuse of disposable instruments may be potentially harmful to the patient.
Urological complications after renal transplantation.
Authors:   Voyno-Yasenetsky Krasnoyarsk State Medical University, Sechenov University, Bezrukov E.A. ,   Krasnoyarsk, Russia, Firsov M.A. ,   Voyno-Yasenetsky Krasnoyarsk State Medical University, Regional Clinical Hospital; Krasnoyarsk, Russia, Arutiunian V.S. ,   Loginov Moscow Clinical Scientific Center; Krasnoyarsk, Russia, Yurchenko A.A. ,   Regional Clinical Hospital; Moskow, Russia, Spirin D.N ,   Voyno-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk, Russia
Published: February 2024

Introduction. Renal transplantation is the standard of medical care in the treatment of patients with end-stage chronic kidney disease. It increases patient survival in the next five years by 87-93%. Urological complications after transplantation remain one of the main problems – on average they amount to 4-14%. Material and methods. We searched for publications in the PubMed and eLibrary databases using the keywords «kidney transplantation», «urological complications», «post-transplantation period», «urinary leakage», «ureteral stricture», «vesicoureteral reflux». As a result of the search, 57 sources were selected that were used when writing the literature review. Results. By reviewing various studies of complications in the post-transplant period, we identify and characterize the main urological complications of renal transplantation, such as urine leak, hematuria, ureteral stricture, kidney stones and vesicoureteral reflux. The article also reflects the ways of correcting these complications. Conclusions. The analysis showed that proper preoperative urological evaluation of the recipient and correction of urodynamic disorders are crucial to prevent the development of complications; the survival of the transplant directly depends on a multidisciplinary team approach to kidney transplantation and the inclusion of a urologist in the pre- and postoperative monitoring of the patient.
Estimation of the results of laparoscopic pyeloplasty in primary strictures of the pelvic-ureteral segment.
Authors:   the urology center of the «Medassist» medical center, Panferov A.S. ,   Kursk, Russia, Bekreev E.A. ,   the urological department of the urology center of the «Medassist» medical center; Kursk, Russia, Malkhasyan V.A. ,   the Department of Urology, Department of Urology A.I. Yevdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of the Russian Federation; Moscow, Russia
Published: February 2024

Introduction. In 1993, W.W. Schuessler et al. laparoscopic pyeloplasty was reported, and since that time the number of interventions performed with such access has increased significantly. Laparoscopic pyeloplasty does not exclude possible complications, including early ones - urinary congestion, anastomosis failure and distant ones, restenosis and obliteration of the ureteral lumen, which can develop as a result of ischemia due to excessive tissue tension. There are isolated references in the literature about the positive effect of prestenting on the results of pyeloplasty. Objective. Estimate the results of laparoscopic pyeloplasty in patients without prestenting and with prestenting. Materials and methods. A retrospective analysis of the treatment of 73 patients with stricture of the pelvic ureteral segment is presented. All patients were divided into two groups: I (main) – 17 patients whose upper urinary tract was drained by a ureteral stent at the time of surgery, II (control) - 56 patients who had not previously had upper urinary tract drainage. Results. The results, nature and frequency of complications of laparoscopic pyeloplasty in patients with and without prestenting are analyzed. The average operation time in group I was about 153.85 minutes, in group II - 116.7 minutes, the average drainage time in group I was 22.1 hours, in group II - 30.8 hours. Requirement for analgesics: group I – 48.5 mg/day, group II – 56.2 mg/day. In group I, one complication (5.9%) of category 1 was recorded - an attack of pyelonephritis and one case of complications (5.9%) of category 3a (urinoma). In group II, 6 cases (10.7%) of category 1 complications, 9 cases (16.1%) of category 3a complications were recorded. The results according to MSCT, performed 3 months after surgery, demonstrated restoration of patency at the level of the ureteropelvic segment. Conclusions. Prestenting of the ureter reduces the frequency of postoperative complications during laparoscopic pyeloplasty and eliminates the need for additional mobilization of the kidney for the formation of ureteropyeloanastomosis without excessive tension.
The role of multicomponent complex of nutrients for men in the pre-conception preparation of a married couple for conceiving.
Authors:   the Department of Urology named after E.V. Shakhov FGBOU VO «PIMU», Nashivochnikova N.A. ,   Nizhny Novgorod, Russia, Krupin V.N. ,   the Department of Urology named after E.V. Shakhov of the Federal State Budgetary Educational Institution «PIMU» of the Ministry of Health of Russia; Nizhny Novgorod, Russia
Published: February 2024

Introduction. The COVID-19 pandemic has also greatly impacted people's psychological well-being, increasing stress levels, as well as their lifestyle and well-being. Therefore, to maintain health, men should take multicomponent complexes that have a beneficial effect on various organs and systems (including reproductive), have an antioxidant effect and help normalize basic physiological processes in the body. In particular, such supplements can be used as a preconception preparation of a man for conception in a couple. Objective. To evaluate the action of the antioxidant complex «AndroDoz Light» in a group of men in the framework of preconceptional preparation (for conception of a child by a sexual partner). Materials and methods. The data of 30 men aged 23 to 48 years (the average age was 26.3 ± 5.4 years) preparing for conception with a sexual partner were analyzed in this paper. AndroDoz Light was used by men for 1 month: effervescent tablet dissolved in a glass of water (200 ml) once a day during or after meals. To everyone in addition to the spermogram, microbiological examination of the ejaculate, finger rectal examination of the prostate gland (pancreas), ultrasound examination (ultrasound) of the scrotum organs, microscopic examination of the pancreatic secretion (SPH), microscopic examination of the urethral smear and PCR diagnostics of sexually transmitted diseases (androflor) were performed. The concentration of testosterone in the blood, the level of zinc in the sperm plasma were determined. The assessment of the quality of life and sexual function of men was carried out on the IIEF-15 scale (International Index of Erectile Function) and on the NIH-CPSI scale. Results. The multicomponent complex AndroDoz Light helps not only to increase male fertility, improving the functional state of the male reproductive system (qualitative and quantitative spermogram indicators) and morphological indicators: reduces the percentage of sperm with DNA fragmentation, but also improves copulatory function, and is an additional source of necessary nutrients for the male body. Conclusion. The use of the multicomponent complex AndroDoz Light in men as part of the preconceptional preparation of a married couple for conception is accompanied by an improvement in both general well-being and the quality of men's sexual life in general, positively affects the qualitative and quantitative indicators of the spermogram and sperm DNA fragmentation. The results obtained allow us to recommend the use of the multicomponent complex AndroDoz Light in men in the absence of pronounced reproductive problems as part of the preconceptional preparation of a married couple for conception.
Lifestyle of a modern man as a risk factor for the development of urological diseases: from prevention to treatment.
Authors:   the Russian Academy of Sciences, Kamalov A.A. ,   Medical Research and Educational center, Lomonosov Moscow State University,   Urology and Andrology, Faculty of Fundamental Medicine, Lomonosov Moscow State University,   Moscow, Russia, Nesterova O.Yu. ,   Urology and Andrology Unit, Medical Research and Education center, Lomonosov Moscow State University; Moscow, Russia
Published: February 2024

Introduction. Over the past decades, in the era of urbanization, man is faced with a large number of risk factors that become an integral part of his daily life. Thus, high levels of stress, unbalanced nutrition, physical inactivity, irregular sex life leads to an increased risk of developing a number of diseases, including the organs of the genitourinary system. This review is devoted to assessing the role of various drugs and dietary supplements in maintaining urological health. Materials and methods. The search for the necessary literature for the review was carried out in the PubMed database, in the Russian scientific eLibrary eLibrary.ru and in the search engine « Google Scholar». Results. From the point of view of pathophysiology, useful and effective drugs and complexes are a whole line, ranging from the Vitaprost®, used in the treatment of prostatitis in men, to the biologically active supplement Urinal® Nephro, used to facilitate the removal of concretions and improve the functional state of the urinary system. Some of dietary supplements proved to be useful for male fertility and sexual life of men improvement, providing a complex antioxidant effect on the state of the reproductive system, as well as having an anti-inflammatory effect. Conclusion. In the conditions of growing urbanization, men should not forget about the available opportunities for maintaining urological health, which, along with eliminating or minimizing risk factors, will help not only preserve, but also increase the potential of a modern person, unwittingly drawn into the cycle of inevitable social dangers for his own physical well-being.
Building Motivation for Learning Indonesian Language: Psychological and Social Strategies
Authors: Rulyandi Rulyandi , Nasri Ulyan
Published: February 2024

Acquiring proficiency in Indonesian involves diverse psychological and social elements shaping learners' motivation. This abstract examines strategies to enhance motivation for Indonesian language acquisition, drawing from psychological and social insights. Understanding these strategies is pivotal for educators and learners to optimize language learning outcomes. This study adopts a mixed-method approach, integrating quantitative and qualitative analyses. Data collection includes surveys identifying intrinsic and extrinsic motivational factors impacting Indonesian language learning, alongside in-depth interviews to delve into students' motivational experiences. Quantitative analysis involves descriptive and regression statistical techniques to reveal relationships between motivational factors and language proficiency. Qualitative analysis employs coding and thematic processes to uncover motivational patterns from interviews. Results highlight intrinsic factors like personal interest and satisfaction as key in sustaining motivation. Meanwhile, extrinsic factors such as recognition also influence motivation significantly. These findings stress the importance of a holistic approach to motivation in language learning. Implications underscore educators' need to address both intrinsic and extrinsic motivators in designing effective learning strategies. Utilizing a comprehensive psychological and social framework, educators can create supportive environments fostering higher Indonesian language proficiency. This can positively impact academic performance and personal growth.
Uso de Benzodiazepínicos por idosos em uma unidade de saúde da família do município do Rio de Janeiro
Authors: Pontes Milena Rodrigues , Barreto Ana Clara Faria da Cruz , Dantas Guilherme Pinto , CORREA ANA CLARA FARIA BARCELLOS , Silva Martina Hilário , Nolêto Eduardo Micelli , Nogueira Marina , ROCHA ALBERTO FREDERICO PENNA CHAVES DA , Guadalupe Julia Dessimoni Teixeira , Menasche Nathalie Dockhorn , Gonçalves Bernardo de Moura Japiassú , Moraes Maria Eduarda Bianchi Bitar de
Published: February 2024

RESUMO
Desde a década de 60 os benzodiazepínicos se tornaram o principal meio de tratamento dos transtornos psíquicos sendo muitas vezes usados de forma abusiva. O uso dessa classe medicamentosa na p
Plantio de mandioca consorciado com feijão: Relato de experiência de aula prática, Manacapuru- Am.
Authors: Sampaio Myucha farias , Corrêa Raquel da Silva
Published: February 2024

A mandioca (Manihot esculenta Crantz), também conhecida por macaxeira de mesa, macaxeira ou aipim, é um dos alimentos mais consumidos no mundo, apresenta um alto teor energético e exerce um importante
A importância da inteligência de ameaças na análise de segurança em sistemas de monitoramento de bombas de combustíveis
Authors:   , Cassitas Guilherme Rizze
Published: February 2024

Este artigo evidencia a importância da inteligência de ameaças e a segurança de operações em serviços essenciais, como medição dos níveis de combustível nos tanques e nas bombas de combustíveis. Bem como analisar o quão exposto na internet, estão estes serviços e dados relacionados aos mesmos.
O USO POTENCIAL DO CANABIDIOL PARA O TRATAMENTO DA DEPENDÊNCIA DE BENZODIAZEPÍNICOS E OUTROS MEDICAMENTOS SEDATIVOS E HIPNÓTICOS
Authors:   , Ruberti Maristela
Published: February 2024

Os benzodiazepínicos (BZDs) são classificados como medicamentos sedativo-hipnóticos e são usados para tratar uma variedade de condições, incluindo insônia e distúrbios de ansiedade, distúrbios relacionados ao álcool, convulsões e espasticidade. Eles apresentam um perfil de efeitos colaterais mais favoráveis em comparação aos barbitúricos. No entanto, tais medicamentos têm sido associados à dependência e ao abuso. Muitos estudos têm evidenciado o potencial terapêutico de substâncias que atuam no sistema endocanabinóide para o manejo de muitas condições clínicas, entre elas a dependência química. Neste trabalho, apresentamos uma visão geral dos estudos com foco nos efeitos terapêuticos do uso dos canabinóides, principalmente, do óleo de Canabidiol no tratamento da dependência química e dos efeitos da abstinência. Para tanto, foi realizada uma revisão bibliográfica baseada em artigos que já apontam para o possível uso do óleo de CBD como estratégia para o tratamento de pacientes com transtorno de ansiedade e insônia, dependência química e para o tratamento de epilepsia. Os estudos dos últimos dez anos mostraram que o Canabidiol (CBD) trouxe muito mais benefícios para os pacientes do que outros medicamentos da classe dos BZD, o principal benefício foi a segurança apresentada pelo CBD. Não foram relatados casos de intoxicação e mesmo em doses mais baixas a melhora dos pacientes foi significativa. Observou-se em muitos casos que o CBD foi utilizado como um método para evitar ou reduzir os medicamentos psiquiátricos comumente utilizados na prática clínica. O efeito terapêutico do CBD provém da sua ação moduladora anti-inflamatória, analgésica, antioxidante e neuroprotetora do sistema endocanabinóide.
Research Based on The Passenger’s Perspective to Airline Alliances, The Case of Turkish Airlines, A member of Star Alliance
Authors: GELİRLİ Nalan
Published: February 2024

There is a substantial degree of cooperation between two or more airlines in an alliance. Strategic alliances are formed for a variety of reasons. As a result of airline alliances (e.g., Star Alliance, Oneworld, Skyteam), airlines are able to increase profitability, reduce costs, and expand their flight networks. As part of its commitment to passengers, Turkish Airlines (hereinafter referred to as 'THY') offers flight check-in, baggage handling, a broad network, high-quality catering, in-flight comfort, and on-time departures and arrivals. An assessment of customer perceptions of THY's alliance was conducted to determine whether alliance strategies affected perceived service quality. Travelers who have flown with Turkish Airlines, the flag carrier of Turkey and a Star Alliance member, were surveyed to compare the impact of alliance strategies on service quality before and after joining the alliance. The survey was completed by 147 participants and analyzed using SPSS.
Wild Alaskan salmon supplementation increases 25-OHD levels in sled dogs
Authors: Kali Ann Striker  , Scott Painter Jerome  , Scott Painter Jerome  , Mari Høe-Raitto  , Laura Kay Falkenstein  , Lawrence Kevin Duffy  , Kriya Lee Dunlap
Published: February 2024

Vitamin D deficiency affects canines and humans alike. Athletes are a particularly high-risk group. Further research regarding optimal intake and supplementation is needed to establish the parameters of vitamin D status in both humans and canines and to create a physiologically-relevant definition for vitamin D sufficiency. The objectives of this study were to (1) compare 25-OHD (25-hydroxy vitamin D) levels in sled dogs before and after receiving a diet supplemented with wild Alaskan salmon and (2) correlate biomarkers associated with vitamin D metabolism to 25-OHD levels in sled dogs. Plasma samples from 14 working sled dogs between 10 months and 7 years of age were collected before and after a 4-week supplementation with »0.45 kg of salmon/day. Samples were analyzed using enzyme-linked immunosorbent assays (ELISA) for parathyroid hormone and vitamin D binding protein (DBP); 25-OHD levels were measured via radioimmunoassay. 25-OHD and DBP in sled dogs significantly increased after a 4-week supplementation with salmon (P=0.0011 and 0.0367, respectively). Additional variations in 25-OHD were observed when separated by sex (P=0.0404) and age (P<0.0001). 57% of the dogs were deficient prior to the salmon supplementation and 14% at the completion of the study. Wild Alaskan salmon is one of the few food sources that provide appreciable amounts of vitamin D. A 4-week salmon supplementation in sled dogs was sufficient to improve 25-OHD concentrations in most sled dogs in this study. Confounding factors such as age and sex affect circulating 25-OHD levels.
Knowledge of the risks and benefits of fish consumption among the populations of Sibiti
Authors: Bertin Mikolo  , Vital Mananga  , Anthelme Tsoumou
Published: February 2024

The aim of this work was to gain a comprehensive understanding of the public's awareness, perceptions, and knowledge regarding the potential advantages and disadvantages associated with eating fish in Sibiti. The main source of animal protein in Sibiti is games, but logging societies have led to a shortage of local meat and low fish production. To improve animal protein supply, local fishing can be developed to increase fish production. Fish are rich in essential nutrients and have a reduced risk of diseases. The investigation took place in Sibiti, the capital of the Lékoumou department in the southwest of the Republic of Congo. A total of 100 people were interviewed, with data collected through in-person surveys. The majority of respondents, aged 26-45, considered fish nutritious but overlooked health benefits like reducing heart disease, cancer, and life expectancy. They were unaware of vitamin D and omega-3 fatty acid intake, and potential dangers like PCBs, heavy metals, and parasites. The effects of certain constituents and contaminants were not well understood. The Lékoumou department should be educated on the benefits and risks of fish consumption, as this knowledge promotes safe consumption. However, excessive consumption can pose health risks, and benefits depend on factors like frequency, species, processing methods, education, and income.
Extraction, phytonutrients, the nutraceutical, and mineral analysis of coconut (Cocos nucifera) oil
Authors: Tolulope Margret ILESANMI  , Dayo Mary FAKOMITI
Published: February 2024

Coconut oil is edible oil which is derived from the kernels, meat, and milk of the coconut palm fruit. This study aimed at evaluating the physicochemical properties, mineral elements, phytochemical content of coconut oil and determines the susceptibility pattern of coconut oil against bacteria. The results revealed the average values of the coconut oil contains for alkaloid, tannin, saponins, flavonoid, phenol, steroid, terpenoid, and glycoside were 38.230 mg/100g, 28.124 mg/100g, 16.185 mg/100g, 29.745 mg/100g, 79.167 mg/100g, 0.915 mg/100g, 1.251 mg/100g, and 0.506 mg/100g respectively; which are considered to be responsible for the many benefits attributed to coconut consumption. The mineral elements such sodium (75.350 ppm), calcium (105.400 ppm), potassium (502.55 ppm), magnesium (24.502 ppm), phosphorus (20.372 ppm), and copper, zinc, iron and manganese were present in moderate amounts of 0.442 ppm, 0.393 ppm, 0.772 ppm, 0.629 ppm respectively. The physicochemical analysis reveal the pH level to be neutral, while other parameters such as nitrate, phosphate and ammonia were not detected. The assay of antibacterial activity of standard bacteria organisms showed that Staphylococcus aureus had the highest susceptibility to coconut oil while Pseudomonas aeruginosa had the least. The utilization of coconut oil should be promoted as a functional food in Nigeria and the use of coconut seed flesh in our diets should be encouraged for health supporting functions.
Anticlastogenic potential of euphorbia heterophylla leaf extract against lead-induced polychromatic erythrocytes and tissue atrophy
Authors: Oyewumi Nather Oyewole  , Ifeoluwa Lois Onifade  , Folasade Bosede Oluwatobi  , Oladimeji Samuel Tugbobo
Published: February 2024

Myriads of research reviews have justified that unrestricted and uncontrolled exposure to heavy metal contamination through occupation and environmental pollution generally result in health risks with attendant health burdens including genetic birth defects. This study evaluates the anticlastogenic potential of Euphorbia heterophylla leaf extract against lead-induced polychromatic erythrocytes and the damaged tissues of the albino rats. A total of sixty (60) albino rats were segregated into three sets namely Set I, II and III. Each set contains twenty albino rats which were then divided into four groups A, B, C and D containing five rats each. Group A serves as control and were treated with distilled water only. Group B rats received 2.5 mg/kg lead acetate while group C rats were simultaneously fed 25, 50 and 100 mg/kg Euphorbia heterophylla leaf extract concentrations and 2.5 mg/kg lead acetate at ratio 1:1. Rats in group D were administered 25, 50, and 100 mg/kg Euphorbia heterophylla leaf extract. The schedule of the animal treatment was divided into three set I, II and III while micronucleus assay and histopathological examination were carried out on the test animals. Results show that polychromatic erythrocytes induced by lead acetate was significantly (P<0.05) reduced in group C animals (6%), while lead acetate administered to animals in group B was highly clastogenic. Besides, the histopathological architecture of the rat tissues indicates protection offered by the extract against tissue atrophy.
A comparative study of efficacy and safety of drugs in stage I hypertensive patients attending cardiac OPD at tertiary care hospital
Authors: Korrapati Rajini Naidu  , SK Harshiya
Published: February 2024

To study the efficacy and safety profile of Azilsartan 40 mg and Olmesartan 40 mg in stage I systemic Hypertension among patients attending cardiac OPD in a tertiary care center. All patients with stage I systemic hypertension of either sex, aged 20-65 years, with blood pressures of >140/90 mmHg or diabetes mellitus attending the cardiac outpatient. After initial screening, diagnosed cases of essential hypertension were randomly allocated to either group 1 (Tablet Azilsartan 40 mg or group 2 (Tablet Olmesartan 40 mg). The patients were advised to report for follow-up for review on the 4th, 8th, 12th, and 24th week.The mean decrease in the systolic blood pressure in both groups was statistically significant with a P value of <0.0000001. Both drugs controlled blood pressure at similar proportions. However, the mean of SBP and DBP for the Azilsartan group was lower than the Olmesartan Group. Both drugs were tolerated well, and no significant adverse effects were noted during the study.
Нyperdiploid мultiple мyeloma-cytogenetic and clinical aspects
Authors: Ivan Kindekov  , Liliya Grahlyova  , Nina Petkova  , Antoniya Nedeva
Published: February 2024

In the current research the attention is focused on the possibilities of identifying a hyperdiploidy myeloma clone (HdMC) by using a triple-color fluorescence “in situ” hybridization (FISH) probe. The cytogenetic results from the bone marrow aspirates of 26 patients with newly diagnosed multiple myeloma admitted in the Hematology Department of our hospital during the period from March to September 2023 have been analyzed. The group consists of 12 female and 14 male patients with an average age of 67 years. A FISH probe for establishing hyperdiploidy myeloma clone was used as well as the most common methods for detecting genetic aberrations affecting the long and short arms of the 1 and 14q32 chromosome rearrangements. According to the results, two subgroups of patients have been established. The first subgroup consists of the patients with positive FISH probes for hyperdiploidy myeloma and/or 14q34 rearrangements and 1q25/1p36, while the second one consists of patients, negative for all the three probes listed above. A comparison between the demographic, laboratory data and the ISS (International Staging System) stage of the two subgroups has been made. The collected data suggests that the use of the triple-color FISH probe, as well as some other factors in the analyzed information, increases the probability of detecting a HdMC by 23%.
Verification of the analytical performance of the serum Folate assay on the Abbott Alinity ci®
Authors: Zaïnab Kajeiou  , Issam Mokhtari  , Loubna Yacoubi  , Amina Himri  , Dounia El Moujtahide  , El Houcine Sebbar  , Mohammed Choukri
Published: February 2024

In the evolving landscape of clinical diagnostics, the significance of folate takes center stage as precision and innovation shape advancements in analytical methodologies. Folate, a pivotal element in cellular metabolism, governs physiological processes and serves as an indicator for various medical conditions. This study employs the Chemiluminescent Microparticle Immunoassay (CMIA), known for its accuracy, to assess the reproducibility and repeatability of serum folate levels. Folate's role in cellular metabolism influences diverse physiological functions, making its precise quantification crucial for identifying and monitoring conditions such as folate deficiency. The CMIA method emerges as a robust approach, leveraging immunological specificity for high precision and reliability. Utilizing the Abbott Alinity ci® Analyzer, a technologically advanced clinical chemistry instrument, this study incorporates a systematic analytical method verification procedure. This involves quantification through a standardized protocol and a comparative analysis against criteria set by esteemed societies (RICOS and FSCB), ensuring comprehensive insights into analysis techniques. The reproducibility test, evaluating the impact of various factors on assay results, reveals low Coefficient of Variation (CV) values (CV1: 10.25%, CV2: 8.58%, CV3: 9.13%) across different levels. The results align with quality control limits, emphasizing the method's reliability. Repeatability assessment demonstrates exceptionally low CV values (CV1: 4.84%, CV2: 3.41%, CV3: 1.89%), highlighting the method's stability and precision under controlled conditions.
Assessing the impact of artificial intelligence and machine learning on forecasting medication demand and supply in public pharmaceutical systems: A systematic review
Authors: Tangi Ndakondja Angula  , Abraham Dongo
Published: February 2024

Background: Effectively managing drug demand and supply through pharmaceutical quantification is critical as it ensures that medications are readily available when needed while reducing costs, optimizing inventory management, and ultimately improving patient care. This research aimed to examine the existing literature on the influence of artificial intelligence (AI) and machine learning (ML) on predicting pharmaceutical demand in public systems. This review focused specifically on the accuracy of these methods, their limitations, and the ethical concerns associated with their use. Methods: The research used PubMed and Google Scholar databases, following PRISMA principles, and yielded 13 peer-reviewed articles. The quality of the included studies was assessed for potential bias using established standard criteria, the Cochrane Risk of Bias Checklist Tool for systematic reviews of intervention. Results: The results show that linear regression and random forest are the predominant models for predicting medication quantities in hospital pharmacies. However, the precision of these models can be affected by data entry inaccuracies and fluctuations. The study identified technical, human, and organizational obstacles as barriers to adoption, as well as problems related to privacy and confidentiality. Conclusion: The use of AI and ML can estimate the demand and supply of medicine in public pharmaceutical delivery systems. The results highlight the importance of further study to improve forecasting algorithm simulation accuracy, broaden single time-series projections to incorporate additional patient-associated factors and investigate various efficiency measures.
ECG pattern among adult patients on antipsychotic medications at the university of port Harcourt teaching hospital, River State, Nigeria
Authors: Chibuike Eze Nwafor  , Chukwuma Ugochukwu Okeafor  , Crown Clement
Published: February 2024

Background: Antipsychotic medications treat neuropsychiatric disorders like Schizophrenia and Bipolar disorder. Despite their symptom management benefits, they carry cardiovascular risks. Electrocardiogram (ECG) monitoring is crucial for detecting abnormalities. This research aims to identify and understand these risks, aiding healthcare professionals in implementing effective monitoring for better patient outcomes. Methods: A retrospective study on subjects who are patients on Antipsychotic medications from the University of Port Harcourt Teaching Hospital (UPTH). Results: In a study with 100 patients on antipsychotic medications, 68% displayed abnormal ECG changes during treatment, while 32% had normal patterns. Left Ventricular Hypertrophy (LVH) and Atrial Enlargements were common, affecting 30% and 26% respectively, while QT interval prolongation was rare (2%). Risperidone, Sodium Valproate, and Trihexyphenidyl showed the most abnormal ECG changes, whereas Olanzapine, Fluoxetine, and Escitalopram were relatively safer. Conclusion: ECG monitoring is an essential component of the management of patients on antipsychotic drugs. It enables the early detection of QT interval prolongation and other cardiac abnormalities, allowing for timely interventions and personalized treatment plans. Our study showed just 2% of the patient had QT interval prolongation, however Left Ventricular Hypertrophy was a common finding in the ECG of the patients, 30%.
Analisis Pengaruh Kompetensi Terhadap Kinerja Customer Complaint Handling Dengan Komitmen Organisasi Sebagai Variabel Moderasi (Studi Pada PT. Pos Indonesia Persero Kantor Regional 7 Jawa Timur 60004)
Authors: Jumadi Jumadi , Santoso Rahmat Agus , Sukaris Sukaris
Published: February 2024

The business continuity of a company is supported by the level of achievement of performance targets that have been set. This study aims to determine the influence of oragnization commitment, employee competence, and the role of organizational commitment moderation in influencing competence on customer complaint handling (CCH) performance at Regional Office 7 East Java Surabaya 60004. The population is all customer service employees at PT Pos Indonesia (Persero) which amounts to 130 people. Sampling uses the total sample method, which is the entire population. This research uses a quantitative approach using deductive methods. The data analysis technique used is the Moderated Regression Analysis (MRA) method using the SPSS For Windows program. The results of this study found that partially the competence and commitment of the organization had a significant positive effect on CCH's performance at PT Pos Indonesia (Persero) Regional Office 7 East Java 60004. In addition, it was found that the organization's commitment was able to moderate the positive influence of competence on CCH performance at PT Pos Indonesia (Persero) Regional Office 7 East Java 60004.
El movimiento leonesista desde el proceso autonómico hasta la actualidad
Authors: Castro Ruiz Jose Ángel
Published: February 2024

Durante la Transición española existió un importante debate acerca del encaje de la Región Leonesa en el mapa autonómico español, finalmente se optó por integrarla con Castilla y crear “Castilla y León” como autonomía. Se trató de un debate muy intenso que suscitó numerosas movilizaciones, cuarenta años después es un debate que sigue muy vivo y que está presente en la sociedad leonesa. En la presente investigación se pone el foco sobre cómo se produce el acceso de las provincias de León, Zamora y Salamanca a su actual autonomía, así como en los movimientos de carácter leonesista y la influencia que tuvieron durante la Transición.
¿Se mantiene el espacio bipolar? El voto de clase, la derecha radical y los valores políticos en el nuevo sistema de partidos español (2011-2019)
Authors: Romero García Manuel
Published: February 2024

España ha sufrido grandes cambios políticos desde la crisis económica de 2008, comenzando por una ola de manifestaciones y el desafío del movimiento independentista catalán, que dieron paso al fin del bipartidismo y el surgimiento de tres nuevos partidos políticos. Nuestro objetivo es examinar si este proceso ha cambiado la base del voto de clase en el país de un espacio bipolar tradicional a uno tripolar, como ha ocurrido en Europa, haciendo énfasis en el ascenso de la derecha radical, representada por VOX. Los resultados sugieren que el espacio bipolar permanece estable y está muy polarizado en las dimensiones económica y cultural entre los dos bloques ideológicos, pese a que la base clasista de la derecha radical es algo ambigua.
Surcando los mares de la gobernanza: Cinco coordenadas de lectura de un concepto babélico
Authors: Chávez Becker Carlos
Published: February 2024

Gobernanza es un término que actualmente forma parte de agendas de investigación en muy diversas disciplinas de las ciencias sociales. Pese a importantes problemas de polisemia, el concepto coloniza nuevos territorios académicos y espacios públicos y se ha masificado su uso como nunca en la historia. En este contexto, el principal objetivo del presente trabajo es ofrecer una modesta contribución para hacer más comprensible el concepto de gobernanza y sus múltiples variantes. Para ello, se ofrecen cinco coordenadas de lectura que pretenden ayudar a dar cierto orden y claridad: 1) al uso del concepto “sin apellidos” en una distinción de su versión analítica y normativa, 2) al uso del concepto “con apellidos”, usando la misma diferenciación, 3) a distinguir los niveles de la gobernanza, 4) a comprender los tiempos de la gobernanza y 5) a rastrear las generaciones y las olas en los estudios de la gobernanza. Al final, se trata de un trabajo eminentemente teórico basado en una cuidadosa selección de significativas contribuciones dentro de la vasta literatura especializada sobre gobernanza.
Eurasianismo y nacionalismo ruso imperialista en Aleksandr Dugin
Authors: Máiz Ramón
Published: February 2024

En este artículo se analizan los principales componentes de la teoría política del pensador ruso Aleksndr Dugin (1962), muy influyente en los círculos del Kremlin y en las posiciones del propio Putin. En su prolífica obra, una visión tradicionalista, deudora de Evola y Guénon, se articula con elementos la Revolución Conservadora alemana y la tradición eurasianista rusa de Gumilev y otros, a lo que se añade un elemento fideista Cristiano Ortodoxo de los Antiguos Creyentes. Se analizan por este orden: 1) las claves tradicionalistas de su pensamiento; 2) los elementos nacionalsocialistas y las deudas con Carl Schmitt y Martin Heidegger; 3) su reelaboración del paneslavismo y el eurasianismo clásicos; y 4) un componente militarista omnipresente que se agudizará con motivo de la invasión de Crimea de 2014. El principio articulador de este abigarrado conjunto de elementos de una síntesis ruso blanco-rojo-pardista, que no duda en instrumentalizar argumentos y conceptos del postmodernismo, está constituido por un nacionalismo imperialista Gran Ruso de naturaleza primordialista. Este último promueve un sistema totalitario y antidemocrático en el interior de Rusia mediante la adhesión incondicional al “Nuevo Zar”, a la vez que designa, de la mano de la lógica amigo/enemigo, sus etnias de exclusión (USA, UE), así como de anexión (Ukrania).
Estimation of noise immunity of ultra-wideband radio communication network based on simulation modeling in Anylogic environment
Authors:   Military Educational and Scientific Center of the Air Force «N.E. Zhukovsky and Y.A. Gagarin Air Force Academy», 394064, Russia, Voronezh, Starykh Bolshevikov str., 54a, Molev A.A. , Titov K.D. ,   Military Educational and Scientific Center of the Air Force «N.E. Zhukovsky and Y.A. Gagarin Air Force Academy», 394064, Russia, Voronezh, Starykh Bolshevikov str., 54a,   Voronezh State University 394018, Russia, Voronezh, University square, 1, Kondaurova V.V. ,   Military Educational and Scientific Center of the Air Force «N.E. Zhukovsky and Y.A. Gagarin Air Force Academy», 394064, Russia, Voronezh, Starykh Bolshevikov str., 54a,   Voronezh State University 394018, Russia, Voronezh, University square, 1
Published: February 2024

The article conducts assessment of noise protection of ultra-wideband radio network under conditions of interference from different sources (with different configuration). It has been shown that ultra-wideband radio technology provides efficient functioning of radio communication networks under interference conditions.
Propagation of a U-shaped radio pulse in a selectively amplifying medium
Authors:   Samara State Technical University  443001, Russia, Samara, Molodogvardeiskaya str., 244, Kulikova A.V. , Bukhman N.S. ,   Samara State Technical University  443001, Russia, Samara, Molodogvardeiskaya str., 244
Published: February 2024

General relations are obtained that govern the evolution of the leading edge of a signal propagating in a selectively amplifying medium. The propagation of a pulse with a rectangular envelope, the carrier frequency of which is close to the frequency of one of the spectral amplification lines of a selective (in frequency) amplifying medium, is considered. The time dependence of the envelope of the initially rectangular signal is studied for various values of the optical thickness of the substance layer for the Gaussian and Lorentzian contours of the spectral line. It is shown that in the case of a shift of the carrier frequency of the signal relative to the center of the spectral line, the interference of the primary and amplified signal can lead to very significant oscillations of the total signal in time.
Promotting Better Learning: estudio de caso en la telesecundaria de Caracha, Michoacán
Authors: Robles Gil Pedro Reygadas , Guzmán Díaz Josefina , Figueroa Palafox Héctor
Published: February 2024

Estudio cualitativo mediante entrevistas semiestructuradas a estudiantes y maestras de la aplicación de la Terapia del Campo de Pensamiento (TFT tapping) en primero y segundo año de la escuela telesecundaria estv16 466 de Caracha, Michoacán, México, que muestra eficacia prometedora de la técnica para el tratamiento emocional, la conducta y el aprovechamiento escolar de manera sencilla y susceptible de réplica masiva.