bluuebunny/crossref_metadata_2025 huggingface dataset:
Solving Non-Linear Fractional Variational Problems Using Jacobi Polynomials
Authors: Singh Harendra , Pandey Rajesh , Srivastava Hari
Published: February 2019

The aim of this paper is to solve a class of non-linear fractional variational problems (NLFVPs) using the Ritz method and to perform a comparative study on the choice of different polynomials in the method. The Ritz method has allowed many researchers to solve different forms of fractional variational problems in recent years. The NLFVP is solved by applying the Ritz method using different orthogonal polynomials. Further, the approximate solution is obtained by solving a system of nonlinear algebraic equations. Error and convergence analysis of the discussed method is also provided. Numerical simulations are performed on illustrative examples to test the accuracy and applicability of the method. For comparison purposes, different polynomials such as 1) Shifted Legendre polynomials, 2) Shifted Chebyshev polynomials of the first kind, 3) Shifted Chebyshev polynomials of the third kind, 4) Shifted Chebyshev polynomials of the fourth kind, and 5) Gegenbauer polynomials are considered to perform the numerical investigations in the test examples. Further, the obtained results are presented in the form of tables and figures. The numerical results are also compared with some known methods from the literature.
Rhodoptilometrin, a Crinoid-Derived Anthraquinone, Induces Cell Regeneration by Promoting Wound Healing and Oxidative Phosphorylation in Human Gingival Fibroblast Cells
Authors: Tseng Chung-Chih , Lai Yu-Cheng , Kuo Tsu-Jen , Su Jui-Hsin , Sung Ping-Jyun , Feng Chien-Wei , Lin Yen-You , Chen Pei-Chin , Tai Ming-Hong , Cheng Shu-Yu , Kuo Hsiao-Mei , Wen Zhi-Hong
Published: February 2019

Gingival recession (GR) potentially leads to the exposure of tooth root to the oral cavity microenvironment and increases susceptibility to dental caries, dentin hypersensitivity, and other dental diseases. Even though many etiological factors were reported, the specific mechanism of GR is yet to be elucidated. Given the species richness concerning marine biodiversity, it could be a treasure trove for drug discovery. In this study, we demonstrate the effects of a marine compound, (+)-rhodoptilometrin from crinoid, on gingival cell migration, wound healing, and oxidative phosphorylation (OXPHOS). Experimental results showed that (+)-rhodoptilometrin can significantly increase wound healing, migration, and proliferation of human gingival fibroblast cells, and it does not have effects on oral mucosa fibroblast cells. In addition, (+)-rhodoptilometrin increases the gene and protein expression levels of focal adhesion kinase (FAK), fibronectin, and type I collagen, changes the intracellular distribution of FAK and F-actin, and increases OXPHOS and the expression levels of complexes I~V in the mitochondria. Based on our results, we believe that (+)-rhodoptilometrin might increase FAK expression and promote mitochondrial function to affect cell migration and promote gingival regeneration. Therefore, (+)-rhodoptilometrin may be a promising therapeutic agent for GR.
Production of Valuable Compounds and Bioactive Metabolites from By-Products of Fish Discards Using Chemical Processing, Enzymatic Hydrolysis, and Bacterial Fermentation
Authors: Vázquez José Antonio , Meduíña Araceli , Durán Ana I. , Nogueira Margarita , Fernández-Compás Andrea , Pérez-Martín Ricardo I. , Rodríguez-Amado Isabel
Published: February 2019

The objective of this report was to investigate the isolation and recovery of different biocompounds and bioproducts from wastes (skins and heads) that were obtained from five species discarded by fishing fleets (megrim, hake, boarfish, grenadier, and Atlantic horse mackerel). Based on chemical treatments, enzymatic hydrolysis, and bacterial fermentation, we have isolated and produced gelatinous solutions, oils that are rich in omega-3, fish protein hydrolysates (FPHs) with antioxidant and antihypertensive activities, and peptones. FPHs showed degrees of hydrolysis higher than 13%, with soluble protein concentrations greater than 27 g/L and in vitro digestibilities superior to 90%. Additionally, amino acids compositions were always valuable and bioactivities were, in some cases, remarkable. Peptones that were obtained from FPHs of skin and the heads were demonstrated to be a viable alternative to expensive commercial ones indicated for the production of biomass, lactic acid, and pediocin SA-1 from Pediococcus acidilactici.
The Spectrum of Small Intestinal Lesions in Patients with Unexplained Iron Deficiency Anemia Detected by Video Capsule Endoscopy
Authors: Contaldo Antonella , Losurdo Giuseppe , Albano Francesca , Iannone Andrea , Barone Michele , Ierardi Enzo , Di Leo Alfredo , Principi Mariabeatrice
Published: February 2019

Background and objectives: Video-capsule endoscopy (VCE) has shown a large range (38–83%) of diagnostic yield in unexplained iron deficiency anemia (IDA) and obscure-occult bleeding. Therefore, we retrospectively investigated the VCE-detected spectrum and the prevalence of small bowel injuries and associated risk factors in inpatients with both of the above reported conditions. Methods: We selected inpatients with IDA (hemoglobin <12 g/dL in women, <13 g/dL in men) and obscure-occult bleeding. We excluded VCE indications other than IDA. Complete medical histories and laboratory tests were collected. All subjects underwent PillCam SB2/SB3. The VCE feature Lewis score was calculated when appropriate. We used the t-test and Fisher’s exact test for continuous and categorical variables, respectively, in univariate analysis. For multivariate analysis, we used binomial logistic regression. Results: We retrieved 109 patients (female:male ratio of 53:56; age 63.4 ± 18.9 years). Eighty patients (73.4%) showed ≥1 small bowel lesions. The Lewis score was calculated in 41 patients: 13 (31.7%) showed a mild (<135) and 28 (68.3%) a moderate-severe (135–790 and >790, respectively) score. In univariate analysis, the small bowel transit time (6.2 ± 2.9 versus 5.2 ± 2.1 h; p = 0.049) and non-steroidal anti-inflammatory drug use for at least two weeks (17.5% versus 0%; p = 0.01) were significantly higher in subjects with injuries. These associations were not confirmed at multivariate analysis. The severity of a lesion directly correlated with proton pump inhibitor (PPI) use and duration (not confirmed in multivariate analysis). VCE can reveal the source of obscure-occult bleeding in a high percentage of unexplained IDAs. A wide spectrum of endoscopic pictures may be found. Known as well as supposed risk factors for small bowel lesions may be detected.
Possible Mechanisms Involved in the Vasorelaxant Effect Produced by Anorexigenic Drugs in Rat Aortic Rings
Authors: García-Alonso Daniela , Morgenstern-Kaplan Dan , Cohen-Welch Ariel , Lozano-Cuenca Jair , López-Canales Jorge Skiold
Published: February 2019

Anorexigenics are compounds capable of reducing or suppressing appetite. Their three main types act on different neurotransmitters, either norepinephrine, serotonin or a combination of both. Among the drugs that act on norepinephrine are fenproporex, amfepramone and clobenzorex. Derivatives of the thyroid hormone triiodothyronine have also been associated with weight loss and used as a controversial treatment for obesity, despite their known cardiovascular side effects. Recent data suggest a possible vasodilating effect for these four substances that might be beneficial in a subset of patients. Herein we performed a systematic review of the literature (with emphasis on recent reports) to determine the implications and mechanisms of the vasodilating effects of some anorectics, specifically fenproporex, clobenzorex, amfepramone and triiodothyronine. Data analysis showed these four drugs to be vasodilating agents for rat aortic rings. The different mechanisms of action include endothelium-dependent vasodilation via activation of the NO-cGMP-PKG pathway and the opening of calcium-activated potassium channels. The finding of vasodilating activity indicates a potential role for some anorexigenic drugs in the treatment of obesity in hypertensive patients. Further in vivo studies are needed to test the clinical benefits of these four drugs.
Chromosomal Microarray Analysis versus Karyotyping in Fetuses with Increased Nuchal Translucency
Authors: Cicatiello Rita , Pignataro Piero , Izzo Antonella , Mollo Nunzia , Pezone Lucia , Maruotti Giuseppe Maria , Sarno Laura , Sglavo Gabriella , Conti Anna , Genesio Rita , Nitsch Lucio
Published: February 2019

We have carried out a retrospective study of chromosome anomalies associated with increased nuchal translucency (NT) in order to compare yield rates of karyotype, chromosome microarray analysis (CMA), and non-invasive prenatal testing (NIPT) in this condition. Presenting with increased NT or cystic hygroma ≥3.5 mm as an isolated sign, 249 fetuses underwent karyotype and/or CMA from 11 to 18 gestational weeks. Karyotype and fluorescence in situ hybridization (FISH) analyses detected 103 chromosomal anomalies including 95 aneuploidies and eight chromosomal rearrangements or derivatives. Further, seven pathogenic copy number variants (CNV), five likely pathogenic CNVs, and 15 variants of unknown significance (VOUS) were detected by CMA in fetuses with normal karyotype. Genetic testing is now facing new challenges due to results with uncertain clinical impacts. Additional investigations will be necessary to interpret these findings. More than 15% of the anomalies that we have diagnosed with invasive techniques could not be detected by NIPT. It is therefore definitely not recommended in the case of ultrasound anomalies. These results, while corroborating the use of CMA in fetuses with increased NT as a second tier after rapid aneuploidy testing, do not suggest a dismissal of karyotype analysis.
Engineering Microfluidic Organoid-on-a-Chip Platforms
Authors: Yu Fang , Hunziker Walter , Choudhury Deepak
Published: February 2019

In vitro cell culture models are emerging as promising tools to understand human development, disease progression, and provide reliable, rapid and cost-effective results for drug discovery and screening. In recent years, an increasing number of in vitro models with complex organization and controlled microenvironment have been developed to mimic the in vivo organ structure and function. The invention of organoids, self-organized organ-like cell aggregates that originate from multipotent stem cells, has allowed a whole new level of biomimicry to be achieved. Microfluidic organoid-on-a-chip platforms can facilitate better nutrient and gas exchange and recapitulate 3D tissue architecture and physiology. They have the potential to transform the landscape of drug development and testing. In this review, we discuss the challenges in the current organoid models and describe the recent progress in the field of organoid-on-a-chip.
Mycobacterium smegmatis But Not Mycobacterium avium subsp. hominissuis Causes Increased Expression of the Long Non-Coding RNA MEG3 in THP-1-Derived Human Macrophages and Associated Decrease of TGF-β
Authors: Sharbati Soroush , Ravon Faustine , Einspanier Ralf , zur Bruegge Jennifer
Published: February 2019

Pathogenic mycobacteria are able to persist intracellularly in macrophages, whereas non-pathogenic mycobacteria are effectively combated and eliminated after their phagocytosis. It is known that TGF-β plays an important role in this context. Infection with pathogenic mycobacteria such as Mycobacterium tuberculosis or M. avium leads to production of active TGF-β, which blocks the ability of IFN-γ and TNF-α to inhibit intracellular replication. On the other hand, it is known that the long non-coding RNA (lncRNA) maternally expressed 3 (MEG3) is involved in the regulation of TGF-β. In this study, we show how the infection of THP-1-derived human macrophages with the saprophytic M. smegmatis but not with the facultatively pathogenic M. avium subsp. hominissuis leads to increased MEG3 expression. This is associated with the downregulation of DNA methyltransferases (DNMT) 1 and 3b, which are known to regulate MEG3 expression via promoter hypermethylation. Consequently, we observe a significant downregulation of TGF-β in M. smegmatis-infected macrophages but not in M. avium subsp. hominissuis pointing to lncRNAs as novel mediators of host cell response during mycobacterial infections.
Fish Protein and Lipid Interactions on the Digestibility and Bioavailability of Starch and Protein from Durum Wheat Pasta
Authors: Desai Ajay , Brennan Margaret , Guo Xinbo , Zeng Xin-An , Brennan Charles
Published: February 2019

This research focussed on the utilisation of salmon protein and lipid to manipulate pasta’s glycaemic index and protein digestibility. Salmon fish (Oncorhynchus tschawytscha) powder (SFP) supplemented pasta flour in amounts from 5% to 20% (w/w). Inclusion of SFP lead to a significant reduction in starch digestibility and hence the potential glycaemic values of pasta (experimental pasta being up to 143% lower than control values). SFP addition to pasta increased the release of phenolic compounds from pasta during both gastric digestion (179%) and pancreatic digestion (133%) in comparison to the control sample. At the same time, the antioxidant activity of the digested pasta was increased by up to 263% (gastric) and 190% (pancreatic) in comparison to durum wheat pasta alone. Interestingly, although protein levels increased with incorporation of SFP, the digestibility values of the protein decreased from 86.41% for the control pasta to 81.95% for 20% SFP pasta. This may indicate that there are interactions between phenols and protein in the pasta samples which affect overall protein digestibility levels.
Chemical Diversity of Codium bursa (Olivi) C. Agardh Headspace Compounds, Volatiles, Fatty Acids and Insight into Its Antifungal Activity
Authors: Jerković Igor , Kranjac Marina , Marijanović Zvonimir , Šarkanj Bojan , Cikoš Ana-Marija , Aladić Krunoslav , Pedisić Sandra , Jokić Stela
Published: February 2019

The focus of present study is on Codium bursa collected from the Adriatic Sea. C. bursa volatiles were identified by gas chromatography and mass spectrometry (GC-FID; GC-MS) after headspace solid-phase microextraction (HS-SPME), hydrodistillation (HD), and supercritical CO2 extraction (SC-CO2). The headspace composition of dried (HS-D) and fresh (HS-F) C. bursa was remarkably different. Dimethyl sulfide, the major HS-F compound was present in HS-D only as a minor constituent and heptadecane percentage was raised in HS-D. The distillate of fresh C. bursa contained heptadecane and docosane among the major compounds. After air-drying, a significantly different composition of the volatile oil was obtained with (E)-phytol as the predominant compound. It was also found in SC-CO2 extract of freeze-dried C. bursa (FD-CB) as the major constituent. Loliolide (3.51%) was only identified in SC-CO2 extract. Fatty acids were determined from FD-CB after derivatisation as methyl esters by GC-FID. The most dominant acids were palmitic (25.4%), oleic (36.5%), linoleic (11.6%), and stearic (9.0%). FD-CB H2O extract exhibited better antifungal effects against Fusarium spp., while dimethyl sulfoxide (DMSO) extract was better for the inhibition of Penicillium expansum, Aspergillus flavus, and Rhizophus spp. The extracts showed relatively good antifungal activity, especially against P. expansum (for DMSO extract MIC50 was at 50 µg/mL).
Green Coffee Extract Improves Cardiometabolic Parameters and Modulates Gut Microbiota in High-Fat-Diet-Fed ApoE-/- Mice
Authors: Caro-Gómez Erika , Sierra Jelver A. , Escobar Juan S. , Álvarez-Quintero Rafael , Naranjo Mauricio , Medina Sonia , Velásquez-Mejía Eliana P. , Tabares-Guevara Jorge H. , Jaramillo Julio C. , León-Varela Yudy M. , Muñoz-Durango Katalina , Ramírez-Pineda José R.
Published: February 2019

Chlorogenic acids (CGA) are the most abundant phenolic compounds in green coffee beans and in the human diet and have been suggested to mitigate several cardiometabolic risk factors. Here, we aimed to evaluate the effect of a water-based standardized green coffee extract (GCE) on cardiometabolic parameters in ApoE-/- mice and to explore the potential underlying mechanisms. Mice were fed an atherogenic diet without (vehicle) or with GCE by gavage (equivalent to 220 mg/kg of CGA) for 14 weeks. We assessed several metabolic, pathological, and inflammatory parameters and inferred gut microbiota composition, diversity, and functional potential. Although GCE did not reduce atherosclerotic lesion progression or plasma lipid levels, it induced important favorable changes. Specifically, improved metabolic parameters, including fasting glucose, insulin resistance, serum leptin, urinary catecholamines, and liver triglycerides, were observed. These changes were accompanied by reduced weight gain, decreased adiposity, lower inflammatory infiltrate in adipose tissue, and protection against liver damage. Interestingly, GCE also modulated hepatic IL-6 and total serum IgM and induced shifts in gut microbiota. Altogether, our results reveal the cooccurrence of these beneficial cardiometabolic effects in response to GCE in the same experimental model and suggest potential mediators and pathways involved.
Variability of Serum Proteins in Chinese and Dutch Human Milk during Lactation
Authors: Elwakiel Mohèb , Boeren Sjef , Hageman Jos A. , Szeto Ignatius M. , Schols Henk A. , Hettinga Kasper A.
Published: February 2019

To better understand the variability of the type and level of serum proteins in human milk, the milk serum proteome of Chinese mothers during lactation was investigated using proteomic techniques and compared to the milk serum proteome of Dutch mothers. This showed that total milk serum protein concentrations in Chinese human milk decreased over a 20-week lactation period, although with variation between mothers in the rate of decrease. Variation was also found in the composition of serum proteins in both colostrum and mature milk, although immune-active proteins, enzymes, and transport proteins were the most abundant for all mothers. These three protein groups account for many of the 15 most abundant proteins, with these 15 proteins covering more than 95% of the total protein concentrations, in both the Chinese and Dutch milk serum proteome. The Dutch and Chinese milk serum proteome were also compared based on 166 common milk serum proteins, which showed that 22% of the 166 serum proteins differed in level. These differences were observed mainly in colostrum and concern several highly abundant proteins. This study also showed that protease inhibitors, which are highly correlated to immune-active proteins, are present in variable amounts in human milk and could be relevant during digestion.
Effect of Iron Supplementation on the Modulation of Iron Metabolism, Muscle Damage Biomarkers and Cortisol in Professional Cyclists
Authors: Córdova Alfredo , Mielgo-Ayuso Juan , Fernandez-Lazaro Cesar I. , Caballero-García Alberto , Roche Enrique , Fernández-Lázaro Diego
Published: February 2019

Background: The intense efforts made during 3-week stage races may reduce iron metabolism and hematological parameters. These efforts may increase the levels of circulating muscle damage markers and some hormones. All of these physiological changes may have negative consequences not only for the performance of athletes but also for their health. The main aim of this study was to evaluate the effects of supplementation with 80 mg/day of iron on haematological parameters, serum cortisol and biochemical muscle indicators on elite male cyclists during the 3-week stage race the Vuelta a España. Our secondary aim was to examine whether the hematological profile is associated with muscular damage parameters and cortisol. Methods: Eighteen elite male cyclists from two teams were randomly assigned to one of two groups: (1) control group (CG, n = 9; age: 26.1 ± 4.6 years; maximum oxygen uptake per kg: 78.0 ± 5.4 mL/kg/min) or (2) group treated with 80 mg/day iron (800 mg of iron protein succinylate, ITG, n = 9; age: 25.7 ± 6.4 years; maximum oxygen uptake per kg: 77.6 ± 6.5 mL/kg/min). The cyclists were subjected to blood tests one week before the start of the race (T1) and after 4 weeks of treatment, coinciding with the end of the competition (T2). Iron metabolism parameters, muscle damage indicators and serum cortisol were assessed. Repeated-measures ANOVA with group as a factor (GC and ITG) were used to examine the differences between groups throughout the study (time × group) after iron supplementation treatment. Results: Significant differences were observed between groups throughout the study in the group-by-time interaction and changes in serum iron (GC: −8.93 ± 10.35% vs. ITG: 0.60 ± 8.64%; p = 0.018), ferritin (GC: −13.88 ± 23.53% vs. ITG: 91.08 ± 118.30%; p = 0.004), haemoglobin (GC: 10.00 ± 3.32% vs. ITG: 13.04 ± 5.64%; p < 0.001), haematocrit (GC: −1.17 ± 3.78% vs. ITG: 7.32 ± 3.92%; p < 0.001) and cortisol (GC: 24.74 ± 25.84% vs. ITG: –13.54 ± 13.61%; p = 0.005). However, no significant group-by-time interaction was observed for the circulating muscle biomarkers. Additionally, significant negative correlations of serum iron, haemoglobin and haematocrit with muscle circulating biomarkers and cortisol (p < 0.05) were observed. Conclusions: Oral iron supplementation with 80 mg/day iron (800 mg of iron protein succinylate) effectively prevented a decline in haematological parameters (serum iron, ferritin, haemoglobin and haematocrit) and maintained optimal levels of recovery in elite cyclists during the Vuelta a España. Moreover, the hematological values were shown to have relationship with muscular recovery parameters.
Cytoplasmic and Mitochondrial NADPH-Coupled Redox Systems in the Regulation of Aging
Authors: Bradshaw Patrick C.
Published: February 2019

The reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) protects against redox stress by providing reducing equivalents to antioxidants such as glutathione and thioredoxin. NADPH levels decline with aging in several tissues, but whether this is a major driving force for the aging process has not been well established. Global or neural overexpression of several cytoplasmic enzymes that synthesize NADPH have been shown to extend lifespan in model organisms such as Drosophila suggesting a positive relationship between cytoplasmic NADPH levels and longevity. Mitochondrial NADPH plays an important role in the protection against redox stress and cell death and mitochondrial NADPH-utilizing thioredoxin reductase 2 levels correlate with species longevity in cells from rodents and primates. Mitochondrial NADPH shuttles allow for some NADPH flux between the cytoplasm and mitochondria. Since a decline of nicotinamide adenine dinucleotide (NAD+) is linked with aging and because NADP+ is exclusively synthesized from NAD+ by cytoplasmic and mitochondrial NAD+ kinases, a decline in the cytoplasmic or mitochondrial NADPH pool may also contribute to the aging process. Therefore pro-longevity therapies should aim to maintain the levels of both NAD+ and NADPH in aging tissues.
Does Dietary-Induced Obesity in Old Age Impair the Contractile Performance of Isolated Mouse Soleus, Extensor Digitorum Longus and Diaphragm Skeletal Muscles?
Authors: Hill Cameron , James Rob S. , Cox Val M. , Tallis Jason
Published: February 2019

Ageing and obesity independently have been shown to significantly impair isolated muscle contractile properties, though their synergistic effects are poorly understood. We uniquely examined the effects of 9 weeks of a high-fat diet (HFD) on isometric force, work loop power output (PO) across a range of contractile velocities, and fatigability of 79-week-old soleus, extensor digitorum longus (EDL) and diaphragm compared with age-matched lean controls. The dietary intervention resulted in a significant increase in body mass and gonadal fat pad mass compared to the control group. Despite increased muscle mass for HFD soleus and EDL, absolute isometric force, isometric stress (force/CSA), PO normalised to muscle mass and fatigability was unchanged, although absolute PO was significantly greater. Obesity did not cause an alteration in the contractile velocity that elicited maximal PO. In the obese group, normalised diaphragm PO was significantly reduced, with a tendency for reduced isometric stress and fatigability was unchanged. HFD soleus isolated from larger animals produced lower maximal PO which may relate to impaired balance in older, larger adults. The increase in absolute PO is smaller than the magnitude of weight gain, meaning in vivo locomotor function is likely to be impaired in old obese adults, with an association between greater body mass and poorer normalised power output for the soleus. An obesity-induced reduction in diaphragm contractility will likely impair in vivo respiratory function and consequently contribute further to the negative cycle of obesity.
A Pathophysiological Model of Non-Alcoholic Fatty Liver Disease Using Precision-Cut Liver Slices
Authors: Prins Grietje H. , Luangmonkong Theerut , Oosterhuis Dorenda , Mutsaers Henricus A. M. , Dekker Frank J. , Olinga Peter
Published: February 2019

Non-alcoholic fatty liver disease (NAFLD) is a common liver disorder closely related to metabolic syndrome. NAFLD can progress to an inflammatory state called non-alcoholic steatohepatitis (NASH), which may result in the development of fibrosis and hepatocellular carcinoma. To develop therapeutic strategies against NAFLD, a better understanding of the molecular mechanism is needed. Current in vitro NAFLD models fail to capture the essential interactions between liver cell types and often do not reflect the pathophysiological status of patients. To overcome limitations of commonly used in vitro and in vivo models, precision-cut liver slices (PCLSs) were used in this study. PCLSs, prepared from liver tissue obtained from male Wistar rats, were cultured in supraphysiological concentrations of glucose, fructose, insulin, and palmitic acid to mimic metabolic syndrome. Accumulation of lipid droplets was visible and measurable after 24 h in PCLSs incubated with glucose, fructose, and insulin, both in the presence and absence of palmitic acid. Upregulation of acetyl-CoA carboxylase 1 and 2, and of sterol responsive element binding protein 1c, suggests increased de novo lipogenesis in PCLSs cultured under these conditions. Additionally, carnitine palmitoyltransferase 1 expression was reduced, which indicates impaired fatty acid transport and disrupted mitochondrial β-oxidation. Thus, steatosis was successfully induced in PCLSs with modified culture medium. This novel ex vivo NAFLD model could be used to investigate the multicellular and molecular mechanisms that drive NAFLD development and progression, and to study potential anti-steatotic drugs.
Anti-TNF-α Agent Tamarind Kunitz Trypsin Inhibitor Improves Lipid Profile of Wistar Rats Presenting Dyslipidemia and Diet-induced Obesity Regardless of PPAR-γ Induction
Authors: Carvalho Fabiana M. C. , Lima Vanessa C. O. , Costa Izael S. , Luz Anna B. S. , Ladd Fernando V. L. , Serquiz Alexandre C. , Bortolin Raul H. , Silbiger Vivian N. , Maciel Bruna L. L. , Santos Elizeu A. , Morais Ana H. A.
Published: February 2019

The increasing prevalence of obesity and, consequently, chronic inflammation and its complications has increased the search for new treatment methods. The effect of the purified tamarind seed trypsin inhibitor (TTIp) on metabolic alterations in Wistar rats with obesity and dyslipidemia was evaluated. Three groups of animals with obesity and dyslipidemia were formed, consuming a high glycemic index and glycemic load (HGLI) diet, for 10 days: Obese/HGLI diet; Obese/standard diet; Obese/HGLI diet + TTIp (730 μg/kg); and one eutrophic group of animals was fed a standard diet. Rats were evaluated daily for food intake and weight gain. On the 11th day, animals were anesthetized and sacrificed for blood and visceral adipose tissue collection. TTIp treated animals presented significantly lower food intake than the untreated group (p = 0.0065), TG (76.20 ± 18.73 mg/dL) and VLDL-C (15.24 ± 3.75 mg/dL). Plasma concentrations and TNF-α mRNA expression in visceral adipose tissue also decreased in obese animals treated with TTIp (p < 0.05 and p = 0.025, respectively) with a negative immunostaining. We conclude that TTIp presented anti-TNF-α activity and an improved lipid profile of Wistar rats with dyslipidemia and obesity induced by a high glycemic index and load diet regardless of PPAR-γ induction.
Introduction of the Special Issue “Religion, Welfare and Social Service Provision: Common Ground”
Authors: Wineburg Robert
Published: February 2019

In the early 1980s, when I was a young assistant professor teaching welfare policy, the Reagan administration’s severe cuts to social services left many of the most needy Americans fending for themselves [...]
Evaluation of Terra-MODIS C6 and C6.1 Aerosol Products against Beijing, XiangHe, and Xinglong AERONET Sites in China during 2004-2014
Authors: Bilal Muhammad , Nazeer Majid , Nichol Janet , Qiu Zhongfeng , Wang Lunche , Bleiweiss Max P. , Shen Xiaojing , Campbell James R. , Lolli Simone
Published: February 2019

In this study, Terra-MODIS (Moderate Resolution Imaging Spectroradiometer) Collections 6 and 6.1 (C6 & C6.1) aerosol optical depth (AOD) retrievals with the recommended high-quality flag (QF = 3) were retrieved from Dark-Target (DT), Deep-Blue (DB) and merged DT and DB (DTB) level–2 AOD products for verification against Aerosol Robotic Network (AERONET) Version 3 Level 2.0 AOD data obtained from 2004–2014 for three sites located in the Beijing-Tianjin-Hebei (BTH) region. These are: Beijing, located over mixed bright urban surfaces, XiangHe located over suburban surfaces, and Xinglong located over hilly and vegetated surfaces. The AOD retrievals were also validated over different land-cover types defined by static monthly NDVI (Normalized Difference Vegetation Index) values obtained from the Terra-MODIS level-3 product (MOD13A3). These include non-vegetated surfaces (NVS, NDVI < 0.2), partially vegetated surfaces (PVS, 0.2 ≤ NDVI ≤ 0.3), moderately vegetated surfaces (MVS, 0.3 < NDVI < 0.5) and densely vegetated surfaces (DVS, NDVI ≥ 0.5). Results show that the DT, DB, and DTB-collocated retrievals achieve a high correlation coefficient of ~ 0.90–0.97, 0.89–0.95, and 0.86–0.95, respectively, with AERONET AOD. The DT C6 and C6.1 collocated retrievals were comparable at XiangHe and Xinglong, whereas at Beijing, the percentage of collocated retrievals within the expected error (↔EE) increased from 21.4% to 35.5%, the root mean square error (RMSE) decreased from 0.37 to 0.24, and the relative percent mean error (RPME) decreased from 49% to 27%. These results suggest significant relative improvement in the DT C6.1 product. The percentage of DB-collocated AOD retrievals ↔EE was greater than 70% at Beijing and Xinglong, whereas less than 66% was observed at XiangHe. Similar to DT AOD, DTB AOD retrievals performed well at XiangHe and Xinglong compared with Beijing. Regionally, DB C6 and C6.1-collocated retrievals performed better than DT and DTB in terms of good quality retrievals and relatively small errors. For diverse vegetated surfaces, DT-collocated retrievals reported small errors and good quality retrievals only for NVS and DVS, whereas larger errors were reported for PVS. MVS. DB contains good quality AOD retrievals over PVS, MVS, and DVS compared with NVS. DTB C6.1 collocated retrievals were better than C6 over NVS, PVS, and DVS. C6.1 is substantially improved overall, compared with C6 at local and regional scales, and over diverse vegetated surfaces.
SDF-MAN: Semi-Supervised Disparity Fusion with Multi-Scale Adversarial Networks
Authors: Pu Can , Song Runzi , Tylecek Radim , Li Nanbo , Fisher Robert B.
Published: February 2019

Refining raw disparity maps from different algorithms to exploit their complementary advantages is still challenging. Uncertainty estimation and complex disparity relationships among pixels limit the accuracy and robustness of existing methods and there is no standard method for fusion of different kinds of depth data. In this paper, we introduce a new method to fuse disparity maps from different sources, while incorporating supplementary information (intensity, gradient, etc.) into a refiner network to better refine raw disparity inputs. A discriminator network classifies disparities at different receptive fields and scales. Assuming a Markov Random Field for the refined disparity map produces better estimates of the true disparity distribution. Both fully supervised and semi-supervised versions of the algorithm are proposed. The approach includes a more robust loss function to inpaint invalid disparity values and requires much less labeled data to train in the semi-supervised learning mode. The algorithm can be generalized to fuse depths from different kinds of depth sources. Experiments explored different fusion opportunities: stereo-monocular fusion, stereo-ToF fusion and stereo-stereo fusion. The experiments show the superiority of the proposed algorithm compared with the most recent algorithms on public synthetic datasets (Scene Flow, SYNTH3, our synthetic garden dataset) and real datasets (Kitti2015 dataset and Trimbot2020 Garden dataset).
Confidence Intervals for the Signal-to-Noise Ratio and Difference of Signal-to-Noise Ratios of Log-Normal Distributions
Authors: Thangjai Warisa , Niwitpong Sa-Aat
Published: February 2019

In this article, we propose approaches for constructing confidence intervals for the single signal-to-noise ratio (SNR) of a log-normal distribution and the difference in the SNRs of two log-normal distributions. The performances of all of the approaches were compared, in terms of the coverage probability and average length, using Monte Carlo simulations for varying values of the SNRs and sample sizes. The simulation studies demonstrate that the generalized confidence interval (GCI) approach performed well, in terms of coverage probability and average length. As a result, the GCI approach is recommended for the confidence interval estimation for the SNR and the difference in SNRs of two log-normal distributions.
Opportunities for Mineral Carbonation in Australia’s Mining Industry
Authors: Azadi Mehdi , Edraki Mansour , Farhang Faezeh , Ahn Jiwhan
Published: February 2019

Carbon capture, utilisation and storage (CCUS) via mineral carbonation is an effective method for long-term storage of carbon dioxide and combating climate change. Implemented at a large-scale, it provides a viable solution to harvesting and storing the modern crisis of GHGs emissions. To date, technological and economic barriers have inhibited broad-scale utilisation of mineral carbonation at industrial scales. This paper outlines the mineral carbonation process; discusses drivers and barriers of mineral carbonation deployment in Australian mining; and, finally, proposes a unique approach to commercially viable CCUS within the Australian mining industry by integrating mine waste management with mine site rehabilitation, and leveraging relationships with local coal-fired power station. This paper discusses using alkaline mine and coal-fired power station waste (fly ash, red mud, and ultramafic mine tailings, i.e., nickel, diamond, PGE (platinum group elements), and legacy asbestos mine tailings) as the feedstock for CCUS to produce environmentally benign materials, which can be used in mine reclamation. Geographical proximity of mining operations, mining waste storage facilities and coal-fired power stations in Australia are identified; and possible synergies between them are discussed. This paper demonstrates that large-scale alkaline waste production and mine site reclamation can become integrated to mechanise CCUS. Furthermore, financial liabilities associated with such waste management and site reclamation could overcome many of the current economic setbacks of retrofitting CCUS in the mining industry. An improved approach to commercially viable climate change mitigation strategies available to the mining industry is reviewed in this paper.
Fusing Sentinel-2 Imagery and ALS Point Clouds for Defining LULC Changes on Reclaimed Areas by Afforestation
Authors: Szostak Marta , Knapik Kacper , Wężyk Piotr , Likus-Cieślik Justyna , Pietrzykowski Marcin
Published: February 2019

The study was performed on two former sulphur mines located in Southeast Poland: Jeziórko, where 216.5 ha of afforested area was reclaimed after borehole exploitation and Machów, where 871.7 ha of dump area was reclaimed after open cast strip mining. The areas were characterized by its terrain structure and vegetation cover resulting from the reclamation process. The types of reclamation applied in these areas were forestry in Jeziórko and agroforestry in the Machów post-sulphur mine. The study investigates the possibility of applying the most recent Sentinel-2 (ESA) satellite imageries for land cover mapping, with a primary focus on detecting and monitoring afforested areas. Airborne laser scanning point clouds were used to derive precise information about the spatial (3D) characteristics of vegetation: the height (95th percentile), std. dev. of relative height, and canopy cover. The results of the study show an increase in afforested areas in the former sulphur mines. For the entire analyzed area of Jeziórko, forested areas made up 82.0% in the year 2000 (Landsat 7, NASA), 88.8% in 2009 (aerial orthophoto), and 95.5% in 2016 (Sentinel-2, ESA). For Machów, the corresponding results were 46.1% in 2000, 57.3% in 2009, and 60.7% in 2016. A dynamic increase of afforested area was observed, especially in the Jeziórko test site, with the presence of different stages of vegetation growth.
Evaluating Residential Consumers’ Willingness to Pay to Avoid Power Outages in South Korea
Authors: Kim Ju-Hee , Lim Kyung-Kyu , Yoo Seung-Hoon
Published: February 2019

South Korea experienced a nationwide rolling blackout in 2011 due to a rapid increase in the power demand and a lack of power supply facilities. In particular, the residential sector suffered from considerable inconveniences due to power outages, such as the interruption of elevators’ operation and the stopping of all electronic appliances. Since then, ensuring a stable supply of electricity has emerged as an important task. This note aims to analyze residential consumers’ willingness to pay (WTP) to avoid power outages. For this purpose, 1000 households were surveyed, applying the contingent valuation (CV) method during May 2018. The respondents understood the CV question well and gave meaningful answers. The results show that the mean of households’ monthly WTP amounts to KRW 1522 (USD 1.41). This value is statistically significant. Converting it into an annual value and then expanding the value to the country indicate that the annual national value amounts to KRW 360.7 billion (USD 335.3 million). Since a substantial amount of investments should be made by power suppliers to prevent power outages in the residential sector, this value may be accepted as the upper limit of the benefits ensuing from those investments.
Exploring the Potential Use of Near-Miss Information to Improve Construction Safety Performance
Authors: Zhou Zhipeng , Li Chaozhi , Mi Chuanmin , Qian Lingfei
Published: February 2019

Construction project management usually has a high risk of safety-related accidents. An opportunity to proactively improve safety performance is with near-miss information, which is regarded as free lessons for safety management. The research status and practice; however, presents a lack of comprehensive understanding on what near-miss information means within the context of construction safety management. The objective of this study is to fill in this gap. The main findings enrich the comprehensive understanding of the near-miss definition, the near-miss causation model, and the process of near-miss management. Considering that near-misses are more tacit and obscure than accidents, the process for near-miss management involves eight stages: discovery, reporting, identification, prioritization, causal analysis, solution, dissemination, and evaluation. The first three stages aim to make near-misses explicit. The other five are adopted to better manage near-miss information, compiled in a well-designed near-miss database (NMDB). Finally, a case study was conducted to show how near-miss information can be utilized to assist in construction safety management. The main potential contributions here are twofold. Firstly, corresponding findings provide a knowledge framework of near-miss information for construction safety researchers who can go on to further study near-miss management. Secondly, the proposed framework contributes to the guidance and encouragement of near-miss practices on construction sites.
Modelling the Impact on Root Water Uptake and Solute Return Flow of Different Drip Irrigation Regimes with Brackish Water
Authors: Slama Fairouz , Zemni Nessrine , Bouksila Fethi , De Mascellis Roberto , Bouhlila Rachida
Published: February 2019

Water scarcity and quality degradation represent real threats to economic, social, and environmental development of arid and semi-arid regions. Drip irrigation associated to Deficit Irrigation (DI) has been investigated as a water saving technique. Yet its environmental impacts on soil and groundwater need to be gone into in depth especially when using brackish irrigation water. Soil water content and salinity were monitored in a fully drip irrigated potato plot with brackish water (4.45 dSm−1) in semi-arid Tunisia. The HYDRUS-1D model was used to investigate the effects of different irrigation regimes (deficit irrigation (T1R, 70% ETc), full irrigation (T2R, 100% ETc), and farmer’s schedule (T3R, 237% ETc) on root water uptake, root zone salinity, and solute return flows to groundwater. The simulated values of soil water content (θ) and electrical conductivity of soil solution (ECsw) were in good agreement with the observation values, as indicated by mean RMSE values (≤0.008 m3·m−3, and ≤0.28 dSm−1 for soil water content and ECsw respectively). The results of the different simulation treatments showed that relative yield accounted for 54%, 70%, and 85.5% of the potential maximal value when both water and solute stress were considered for deficit, full. and farmer’s irrigation, respectively. Root zone salinity was the lowest and root water uptake was the same with and without solute stress for the treatment corresponding to the farmer’s irrigation schedule (273% ETc). Solute return flows reaching the groundwater were the highest for T3R after two subsequent rainfall seasons. Beyond the water efficiency of DI with brackish water, long term studies need to focus on its impact on soil and groundwater salinization risks under changing climate conditions.
Recent Advances in Adaptive Catchment Management and Reservoir Operation
Authors: Fu Guangtao , Ni Guangheng , Zhang Chi
Published: February 2019

This editorial introduces the latest research advances in the special issue on catchment management and reservoir operations. River catchments and reservoirs play a central role in water security, community wellbeing and social-economic prosperity, but their operators and managers are under increasing pressures to meet the challenges from population growth, economic activities and changing climates in many parts of the world. This challenge is tackled from various aspects in the 27 papers included in this special issue. A synthesis of these papers is provided, focusing on four themes: reservoir dynamics and impacts, optimal reservoir operation, climate change impacts, and integrated modelling and management. The contributions are discussed in the broader context of the field and future research directions are identified to achieve sustainable and resilient catchment management.
Hydrophilicity and carbon chain length effects on the gas sensing properties of chemoresistive, self-assembled monolayer carbon nanotube sensors
Authors: Casanova-Cháfer Juan , Bittencourt Carla , Llobet Eduard
Published: February 2019

Here we describe the development of chemoresistive sensors employing oxygen-plasma-treated, Au-decorated multiwall carbon nanotubes (MWCNTs) functionalized with self-assembled monolayers (SAMs) of thiols. For the first time, the effects of the length of the carbon chain and its hydrophilicity on the gas sensing properties of SAMs formed on carbon nanotubes are studied, and additionally, the gas sensing mechanisms are discussed. Four thiols differing in the length of the carbon chain and in the hydrophobic or hydrophilic nature of the head functional group are studied. Transmission electron microscopy, Raman spectroscopy and X-ray photoelectron spectroscopy are used to analyze the resulting gas-sensitive hybrid films. Among the different nanomaterials tested, short-chain thiols having a hydrophilic head group, self-assembled onto Au-decorated carbon nanotubes were most responsive to nitrogen dioxide and ethanol vapors, even in the presence of ambient humidity. In particular, this nanomaterial was about eight times more sensitive to nitrogen dioxide than bare Au-decorated carbon nanotubes when operated at room temperature. This response enhancement is attributed to the interaction, via strong hydrogen bonding, of the polar molecules tested to the polar surface of hydrophilic thiols. The approach discussed here could be extended further by combining hydrophilic and hydrophobic thiol SAMs in Au-MWCNT sensor arrays as a helpful strategy for tuning sensor response and selectivity. This would make the detection of polar and nonpolar gas species employing low-power gas sensors easier, even under fluctuating ambient moisture conditions.
Condensation of SiC Stardust in CO Nova Outbursts
Authors: Bose Maitrayee , Starrfield Sumner
Published: February 2019

This study on presolar grains compares high-precision isotopic compositions of individual SiC grains with low 12C/13C ratios, low 14N/15N ratios, large 30Si excesses, and high 26Al/27Al ratios, all available in the presolar grain database, to new CO nova models with white dwarf (WD) masses from 0.6 to 1.35 M
⊙. The models were designed to match the Large Binocular Telescope high-dispersion spectra acquired for nova V5668 Sgr. These CO nova models provide elemental abundances up to calcium and include mixing of WD material into the accreted material in a binary star system under several scenarios, including one where mixing occurs only after temperatures >7 × 107 K are achieved during a thermonuclear runaway (TNR). The 0.8–1.35 M
⊙ simulations where 25% of the WD core matter mixes with 75% of the accreted material (assumed solar) from its binary companion after the TNR has begun provide the best fits to the measured isotopic data in four presolar grains. One grain matches the 50% accreted 50% solar 1.35 M
⊙ simulation. For these five presolar grains, less than 25% of solar system material is required to be mixed with the CO nova ejecta to account for the grains’ compositions. Thus, our study reports evidence of pure CO nova ejecta material in meteorites. Finally, we speculate that SiC grains can form in the winds of cool and dense CO novae, where the criterion C > O may not be locally imposed, and thus nova winds can be chemically inhomogeneous.
The MRI Imprint on the Short-GRB Jets
Authors: Sapountzis Konstantinos , Janiuk Agnieszka
Published: February 2019

Short gamma-ray bursts (GRBs) are presumably results of binary neutron star mergers, which lead to the formation of a stellar mass black hole, surrounded by remnant matter. The strong magnetic fields help collimate jets of plasma, launched along the axis of the black hole rotation. We study the structure and evolution of the accreting plasma in the short GRBs and we model the formation of the base of relativistic, Poynting-dominated jets. Our numerical models are based on general relativistic MHD, axisymmetric simulations. We discuss the origin of variability in the GRB jet emission, the timescales of which are related to the action of the magnetorotational instability in the accreting plasma. We also estimate the value of a maximum achievable Lorentz factor in the jets produced by our simulations and reached at large distances, where the gamma-ray emission is produced.