bluuebunny/crossref_metadata_2025 huggingface dataset:
RESISTANCE AND RESILIENCE IN CHANGING INDONESIA: The Political Struggle and Movement of Hidayatullah
Authors: Adiyono Adiyono , Abdurrohim Abdurrohim
Published: November 2024

This article seeks to endeavors and strategies of an Islamic organization, Hidayatullah, to survive in changing political regimes in the New Order to Reformation period of Indonesia. It was established as an Islamic educational and dakwah (Islamic proselytizing) institution in Balikpapan, East Kalimantan, in 1973. Despite socio-political changes in the country, it has expanded to several provinces in Indonesia which transformed it to become the largest Islamic educational institution with 402 branches of Islamic schools. The organization focuses its activities on Islamic education and dakwah through various ways including printed media such as Suara Hidayatullah magazine, distributed weekly to its branches, mosques, and schools. Based on a literature review of Suara Hidayatullah magazine and interviews with Hidayatullah prominent figures, this article delves into the struggles and movement of Hidayatullah through its dynamics and transformation in socio-political changes in Indonesia. This article argued that in political dynamics and transformation within Hidayatullah organization show the resistance and resilience to survive in the socio-political crisis of Suharto’s New Order era (1966-1998), which discriminated against Islam as a political ideology and in the aftermath of reformation. One of the strategies to comply with the political repressions is to declare Hidayatullah as an Islamic organization like Nahdlatul Ulama (NU) and Muhammadiyah in 2000. This transformation process proves Hidayatullah’s strategic foresight and adaptability in socio-cultural and political changes.
Kyanite-muscovite-dumortierite vein mineralization mechanisms from advanced microstructural analysis using EBSD
Authors: Dandekar Sneha , Mariani Elisabetta , Dandekar Tushar R. , Khatirkar Rajesh K. , Pande Kavita , Gardner Joseph , Bagshaw Heath , Randive Kirtikumar , Peshwe Dilip
Published: November 2024

Dumortierite, an aluminous borosilicate mineral, is relatively rare in Earth’s crust, but it is the second most abundant aluminous borosilicate after tourmaline. Boron is an element with many uses in modern societies worldwide, from health products to wind turbine blades for clean energy, but of limited availability and at future risk of supply. Only a limited number of studies have been published on dumortierite mineralization processes and the factors that control its abundance and distribution remain poorly understood. Here we present the first comprehensive electron backscatter diffraction (EBSD) study of dumortierite mineralization mechanisms in kyanite-muscovite-dumortierite veins occurring in the metapelites of the Amgaon Gneiss Supracrustals, in the Girola hill area, Sakoli region, Central India. Advanced microstructural and chemical analyses show that mixed-mode brittle-viscous deformation in kyanite, by fracturing and easy glide on (100) [001] slip system, facilitates fluid-rock interactions with reactive hydrothermal fluids rich in B, F, and K and containing Na, Ti, Mg, Fe and Pt. These interactions cause the dissolution of kyanite along fracture and cleavage surfaces and the precipitation of muscovite (F = 0.32 wt %) and topaz (F = 16.48 wt %). The motion of ripplocation defects in muscovite facilitates fluid migration along cleavage surfaces and crystallisation of dumortierite needles within these surfaces. Fluid flux removes silica in solution from the system, so reactions may continue. The observed mineral assemblage, the microstructural signature of kyanite and muscovite, the moderate fluorine content of topaz, and low fluorine content of muscovite, together suggest that dumortierite mineralization results from hydrothermal activity, possibly in a transitional magmatic-hydrothermal environment, likely at P > 2.5 kbar and 400°<T < 550°, that could be linked with granite intrusions in the area. Using EBSD we demonstrate that dumortierite mineralization is focussed along muscovite basal cleavage surfaces and dumortierite needle elongation is likely controlled by the fluid flux direction. These new results advance our understanding of dumortierite mineralization mechanisms and conditions and have important implications for our understanding of the distribution of this aluminous borosilicate mineral in muscovite-rich rocks.
Sustainable growth, financial flexibility and working capital management in family firms: An empirical study in Indonesia
Authors: Purwani Tri , Listijo Harto , Abdullah Naziruddin , Sudiyatno Bambang
Published: November 2024

Family firms play an important role in the economies of developing countries such as Indonesia. Proper working capital management is necessary to support the sustainable growth of family firms. This study aims to analyze the characteristics of sustainable growth and working capital management of family firms. The study analyzes family firms by comparing them with non-family firms listed in the LQ45 index of the Indonesian capital market. Using quantitative methods, logistic regression is used to test the hypotheses. The survey sample covers 280 companies from 2015 to 2022. The results of the study show that the elements of sustainable growth of family firms differ from non-family firms only in the leverage element. Family firms tend to have lower leverage than non-family firms. Family firms tend to have more conservative working capital management policies for investment and financing than non-family firms. Family firms also have longer days of accounts payable outstanding than non-family firms, while days of inventory outstanding and days of sales outstanding are not significantly different. This study suggests that family firms should implement a moderate working capital policy to strengthen sustainable growth rates.
AcknowledgementsThe authors would like to thank the Head of Research and Community Service at AKI University who has supported funding for this research. Thank you also to fellow Faculty of Economics and Business lecturers, AKI University who have helped provide the facilities needed for this research.
Therapeutic Modulation of the Microbiome in Oncology: Current Trends and Future Directions
Authors: Saraswat Istuti , Goel Anjana
Published: November 2024

Cancer is a predominant cause of mortality worldwide, necessitating the development
of innovative therapeutic techniques. The human microbiome, particularly the gut microbiota,
has become a significant element in cancer research owing to its essential role in sustaining
health and influencing disease progression. This review examines the microbiome's makeup and
essential functions, including immunological modulation and metabolic regulation, which may
be evaluated using sophisticated methodologies such as metagenomics and 16S rRNA
sequencing. The microbiome influences cancer development by promoting inflammation,
modulating the immune system, and producing carcinogenic compounds. Dysbiosis, or
microbial imbalance, can undermine the epithelial barrier and facilitate cancer. The microbiome
influences chemotherapy and radiation results by modifying drug metabolism, either enhancing
or reducing therapeutic efficacy and contributing to side effects and toxicity. Comprehending
these intricate relationships emphasises the microbiome's significance in oncology and
accentuates the possibility for microbiome-targeted therapeutics. Contemporary therapeutic
approaches encompass the utilisation of probiotics and dietary components to regulate the
microbiome, enhance treatment efficacy, and minimise unwanted effects. Advancements in
research indicate that personalised microbiome-based interventions, have the potential to
transform cancer therapy, by providing more effective and customised treatment alternatives.
This study aims to provide a comprehensive analysis of the microbiome's influence on the onset
and treatment of cancer, while emphasising current trends and future possibilities for therapeutic
intervention.
Metal- and Photocatalyst-Free Sulfonylcyanation of [1.1.1]Propellane with Sulfonyl Cyanide
Authors: Wang Yuying , Dong Jianyang , Xue Dong
Published: November 2024

Background:

Bicyclo[1.1.1]pentanes (BCPs), recognized as bioisosteres for para-disubstituted benzene rings, have gained prominence as valuable bioactive scaffolds in drug research.

Methods:

This study describes a radical-coupling method for the synthesis of sulfonyl-, cy-ano-substituted BCPs from sulfonyl cyanide and [1.1.1]propellane. In this study, the synthet-ic schemes were designed to show the chemical reactions. Nuclear Magnetic Resonance (NMR) and Mass Spectrometry (MS) were used to identify and characterize the final com-pounds.

Results:

This method does not require photocatalysts, metals, or light, generating BCP ni-triles as a useful building block. The synthetic potential of this mild protocol was showcased by the diverse transformations.

Conclusion:

This versatile method significantly expands the range of BCP-type bioisosteres that can be generated.
A Systemic Review on Phytochemicals and Novel Approaches for the
Management of Hepatic Cancer
Authors: Nooreen Zulfa , Sumayya Fariha , Wal Pranay , Goda Chirag , Imran Mohd , Gasmi Amin
Published: November 2024

Introduction:

Hepatic cancer, an aggressive tumour that often develops along with cirrhosis
and chronic liver disease like infections with the hepatitis B and hepatitis C viruses, while nonalcoholic
steatohepatitis, is linked to metabolic syndrome or diabetes mellitus. It is the third most
prevalent cause of cancer-related mortality globally and ranks fifth in cancer incidence. According to
GLOBOCON, the prevalence is expected to rise by 55.0% and the fatalities by 56.4% in the near
future.

Objective:

The present review offered natural plant-based substances and compounds having curative
effects on liver cancer, along with novel drug delivery systems and nanocarrier-based therapies.

Methods:

The literature has been taken from PubMed, Google Scholar, SciFinder, Springer Nature,
Bentham Science, PLOS one, or other internet sites.

Result:

Treatment for heterogeneous malignancy is multidimensional, and care guidelines differ
depending on the specialty and location. Several nutritional herbal remedies and their active phytoconstituents
may have an abundance of impacts on the management of liver cancer, including preventing
the growth and spread of tumor cells, shielding the body from liver carcinogens, boosting the
effects of chemotherapy and immunomodulating the body.

Conclusion:

The treatment of liver cancer involves multidisciplinary and multimodel therapy. The
literature is a compilation of extract, compounds, and novel approaches like nanoparticles, microsphere,
liposomes, niosomes, phytosomes and microparticles. These approaches not only manage
cancer but also boost the immunity of the individuals.
PENGARUH PENAMBAHAN BUBUK Lactobacillus plantarum Dad-13 TERHADAP TOTAL BAKTERI ASAM LAKTAT, SIFAT FISIK, DAN SENSORIS SELAI COKELAT KACANG
Authors:   Universitas Diponegoro, Kamil Rafli , Dewi Swastika ,   Universitas Diponegoro, Legowo Anang Mohammad ,   Universitas Diponegoro, Mukti Naura Poetry Nadima ,   Universitas Diponegoro, Rahayu Endang Sutriswati ,   Universitas Gadjah Mada
Published: November 2024

Lactobacillus plantarum Dad-13 termasuk probiotik yang diisolasi dari dadih yang dapat bermanfaat bagi saluran pencernaan. Penelitian ini bertujuan untuk mengetahui pengaruh penambahan bubuk probiotik L. plantarum Dad-13 terhadap total bakteri asam laktat, warna, total padatan, konsistensi dan karakteristik sensoris serta mengetahui formulasi yang terbaik dalam pembuatan selai cokelat kacang. Model penelitian yang diterapkan yakni Rancangan Acak Lengkap dengan penambahan bubuk L. plantarum Dad-13 yaitu P1 = 1,50%, P2 = 3%, P3 = 4,50%, dan P4 = 6%. Hasil penelitian menujukkan jika penambahan bubuk probiotik L. plantarum Dad-13 dapat meningkatkan nilai total BAL, konsistensi dan menurunkan tingkat kesukaan dari segi rasa, tekstur dan daya oles. Kesimpulan dari penelitian ini adalah bahwa penambahan bubuk probiotik L. plantarum Dad-13 sebesar 3% merupakan perlakuan terbaik, karena telah memenuhi persyaratan minimal konsumsi probiotik serta mendapatkan peringkat tertinggi dalam penerimaan karakteristik sensoris secara keseluruhan.
APLIKASI NATRIUM CARBOXYMETHYL CELLULOSE (NA-CMC) DARI KULIT KACANG KEDELAI SEBAGAI PENSTABIL YOGHURT SUSU SAPI
Authors:   Universitas PGRI Semarang, Jamaludin Chapib , Indrani Retno ,   Universitas PGRI Semarang, Ariani Dina ,   Universitas PGRI Semarang, Muflihati Iffah ,   Universitas PGRI Semarang
Published: November 2024

Keberadaan selulosa dalam kulit kacang kedelai memiliki potensi dalam pembuatan Na- CMC. Penambahan Na-CMC kulit kacang kedelai pada yoghurt susu sapi dapat mencegah terjadinya sineresis. Penelitian ini bertujuan untuk memanfaatkan limbah kulit kacang kedelai menjadi BTP alami Na-CMC kulit kacang kedelai yang berfungsi sebagai penstabil pada produk Yoghurt susu sapi. Rancangan percobaan yang digunakan adalah RAL dengan perlakuan tanpa dan penambahan Na-CMC dengan konsentrasi 0,2%, 0,4%, 0,6% dan 0,8%. Hasil analisis sineresis menunjukkan jika konsentrasi 0,2%, 0,4% dan 0,8% berbeda nyata. Analisis viskositas antara kontrol dengan tiap perlakuan menunjukan hasil tidak berbeda nyata. Analisis total asam tertitrasi pada semua perlakuan menunjukkan hasil tidak berbeda nyata kecuali pada konsentrasi 0,4%. Analisis total padatan terlarut yang didapatkan sesuai standar SNI yaitu berkisar antara 8,22-8,45°Bx. Kesimpulannya hasil analisis sineresis terbaik adalah pada yoghurt susu sapi dengan perlakuan penambahan Na-CMC konsentrasi 0,4%. Viskositas yoghurt susu sapi mengalami peningkatan pada penambahan Na-CMC kulit kacang kedelai konsentrasi 0,6%. Total asam tertitrasi yoghurt susu sapi mengalami penurunan pada penambahan konsentrasi 0,6%. Total padatan terlarut yoghurt susu sapi mengalami peningkatan seiring peningkatan penambahan konsentrasi Na-CMC kulit kacang kedelai.
Genderview Martijn Icks. De latente misogynie in karaktermoord
Authors: Nys Laura
Published: November 2024

Martijn Icks is docent Oude Geschiedenis aan de Universiteit van Amsterdam. Hij promoveerde met een proefschrift over de Romeinse keizer Elagabalus en diens postume reputatie. Icks bestudeert onder meer de representatie en perceptie van de keizerlijke macht, Romeinse kunst, rituelen en gender. Als medeoprichter van het interdisciplinaire onderzoekscentrum CARP (Character Assassination and Reputation Politics) heeft hij veel expertise opgebouwd in de studie van karaktermoord. Een gesprek over karaktermoord, mannelijkheid, politiek en de meerwaarde van een interdisciplinair onderzoeksteam.
“Het ministerschap is niets voor vrouwen”. De karaktermoord op Irene Vorrink in dag- en weekbladen, 1973-1979
Authors: Hendriks Elisa
Published: November 2024

Tot de meest prominente slachtoffers van karaktermoord in politiek en media tijdens de jaren zeventig behoorde minister en wethouder Irene Vorrink (1918-1996) van de Partij van de Arbeid (PvdA). Zowel tijdens haar ministerschap in het kabinet-Den Uyl (1973-1977), als tijdens haar wethouderschap in Amsterdam (1978-1979) was Vorrink bewust en publiekelijk doel van seksistische en negatieve weergaven in de pers die op fatale wijze haar politieke geloofwaardigheid ondermijnden. Het dieptepunt bereikte deze karaktermoord tijdens haar wethouderschap, met als gevolg dat burgers, opgestookt door de media, én journalisten haar aftreden eisten.
Scientific and technical ways of reducing quantitative indicators of false alarms during the operation of an airboard radar station on the background of the underlying surface (earth)
Authors: Mukhin I. E. , Popov A. N. , Khmelevskaya A. V.
Published: November 2024

The purpose of the research is development of scientific and technical ways to reduce the quantitative indicators of false alarms when operating an on-board radar station against the background of the underlying surface (earth) against the background of passive interference.

Methods. When conducting scientific research, methods of probability theory, mathematical statistics, statistical radio engineering and computational mathematics were used. The study identified a number of methods and technical solutions based on them that make it possible to increase the efficiency of the functioning of airborne radar stations against the background of passive interference. The paper proposes a method for expanding the signal spectrum to 1 GHz by reducing the resolved volume of airborne radar stations. Physically, this is determined by the fact that with a decrease in the resolved volume, the size of the underlying surface area from which the signal is reflected decreases. In order to improve the quality of detection of objects against the background of the underlying surface, a method of using polarization modes is proposed.

Results. In the course of the research: a technical solution was proposed based on the method of expanding the signal spectrum to 1 GHz by reducing the resolution volume of airborne radar stations designed to convert radio frequency signals into digital form, using a mixed signal receiver with direct digitization at radio frequency, such as the AD6688 ; a design of a low-baseline radar system has been developed, consisting of two positions, the antennas of which are located within the average width of the lobe of the backscattering diagram of the irradiated object; a feature of the antenna is the ability to receive and emit signals of the same linear polarization, but orthogonal to the polarization of the first position (including . horizontal and vertical polarization signals); an important relation was obtained for a lowbaseline polarization measuring system (MPIS) when the distance between two partial antennas can be much less than the distance to the measured object. 

Conclusion. The scientific article proposes methods and technical solutions based on these methods to reduce the quantitative indicators of false alarms when operating an on-board radar station against the background of the underlying surface (ground) against the background of passive interference. The proposed approach allows us to move on to the synthesis of a low-baseline polarization measuring system.
Impact of Image Content on Medical Crowdfunding Success: A Machine Learning Approach
Authors: Wang Renwu , Xu Huimin , Zhang Xupin
Published: November 2024

Background

As crowdfunding sites proliferate, visual content often serves as the initial bridge connecting a project to its potential backers, underscoring the importance of image selection in effectively engaging an audience.

Objective

This paper aims to explore the relationship between images and crowdfunding success in cancer-related crowdfunding projects.

Methods

We used the Alibaba Cloud platform to detect individual features in images. In addition, we used the Recognize Anything Model to label images and obtain content tags. Furthermore, the discourse atomic topic model was used to generate image topics. After obtaining the image features and image content topics, we built regression models to investigate the factors that influence the results of crowdfunding success.

Results

Images with a higher proportion of young people (β=0.0753; P<.001), a larger number of people (β=0.00822; P<.001), and a larger proportion of smiling faces (β=0.0446; P<.001) had a higher success rate. Image content related to good things and patient health also contributed to crowdfunding success (β=0.082, P<.001; and β=0.036, P<.001, respectively). In addition, the interaction between image topics and image characteristics had a significant effect on the final fundraising outcome. For example, when smiling faces are considered in conjunction with the image topics, using more smiling faces in the rest and play theme increased the amount of money raised (β=0.0152; P<.001). We also examined causality through a counterfactual analysis, which confirmed the influence of the variables on crowdfunding success, consistent with the results of our regression models.

Conclusions

In the realm of web-based medical crowdfunding, the importance of uploaded images cannot be overstated. Image characteristics, including the number of people depicted and the presence of youth, significantly improve fundraising results. In addition, the thematic choice of images in cancer crowdfunding efforts has a profound impact. Images that evoke beauty and resonate with health issues are more likely to result in increased donations. However, it is critical to recognize that reinforcing character traits in images of different themes has different effects on the success of crowdfunding campaigns.
A teleneuropsychological battery for assessing older Panamanian adults: Protocol for a Pilot Feasibility Study (Preprint)
Authors: Santos Luis , Oviedo Diana , Perez-Lao Ambar , Britton Gabrielle B , Smith Glenn
Published: November 2024

BACKGROUND

Teleneuropsychology (TNP) has evidenced to be a crucial tool in the assessment and treatment of individuals with limited access to in-person health services. Studies in Latin America are scarce and there is a pressing need for studies that test the feasibility of TNP and contribute to the development of tools, models, and validations, and the establishment of normative data for the diverse populations of the region.

OBJECTIVE

Conduct a pilot study to test feasibility and generate normative data for a Teleneuropsychology protocol in a Panamanian sample.

METHODS

This is a cross-sectional, descriptive, community-based study derived from the Development and Validation of Teleneuropsychology Normative Data for Older Adults in Florida (FLOAT study). The study’s final sample will include 150 participants (50 years and older). Participants will first undergo an initial screening to determine their eligibility and will be included if they have a basic understanding of and access to technological devices such as telephones, tablets, or computers, are free of cognitive impairment and/or serious health conditions and provide informed consent. Moreover, participants complete two questionnaires: an adapted Spanish version of the Telephone Interview for Cognitive Status of Memory (TICS-M) and the National Alzheimer’s Coordinating Center (NACC) Health Questionnaire to determine if they can continue in the study. Participants who are eligible will be assessed with a TNP cognitive battery and answer questionnaires via a REDCap link.

RESULTS

To date, 67 participants ≥50 years of age (M=62.2, SD=7.6) have been assessed with questionnaires and a complete cognitive test battery. Sociodemographic and clinical characteristics show participants on average had 16.7 years (SD = 1.9) of formal education. Participants showed a high degree of functional independence in performing basic and instrumental activities of daily living and had 1.5 symptoms of depression (SD = 1.8). Regarding the teleneuropsychological tests, when divided by sex, participants showed no significant differences in most tests, except for the MINT naming test, where a higher score was observed in males than females (p < .001). A similar pattern was observed in the verbal fluency test, with males performing better than females (p = .032). A satisfaction questionnaire revealed most participants were satisfied (33.8%) or very satisfied (60%) with the teleneuropsychological assessment, and most participants would recommend this study to others.

CONCLUSIONS

So far, the present study has proven feasible, yet, augmenting the number of participants is necessary to be able to create normative data. This study will be the first in the country and the Central American region to explore and establish teleneuropsychology as a new assessment method, specifically in elderly populations.
Utilizing a journey map to understand the needs of patients with Diabetes Mellitus (DM) on oral medication with a view to enhance medication adherence: Design research for patient-centered digital health interventions. (Preprint)
Authors: Kim Sun Kyung , Hwang Hye Ri , Ko Kimmi
Published: November 2024

BACKGROUND

Patient journey mapping is a visual representation that illustrates the various touchpoints and interactions a patient has with a healthcare system over time. Patient-centered care (PCC) has been valued in diabetes mellitus (DM) patients, where current digital technology has shown potential to optimize medication management.

OBJECTIVE

This qualitative study was performed to develop a journey map to ascertain DM patients’ needs for PCC and digital health technology at touchpoints where barriers exist for medication adherence.

METHODS

The study consisted of four phases: 1) in-depth interviews were first conducted with 12 diabetes mellitus (DM) patients, followed by 2) a systematic review of systematic reviews to identify digital health technologies, which 3) were synthesized with PCC opportunities. Lastly, 4) a patient journey was mapped to highlight touchpoints requiring PCC intervention within the context of digital health. The study unravels the intricate journey from diagnosis to ongoing medication for long-term use. Personas were used to independently explain how patients either adhere well to or poorly follow their regimen. The touchpoints were tailored where digital health technology enables opportunities for PCC in medication management.

RESULTS

Findings from the qualitative analysis shed light on personalized user experiences, accessibility challenges, and motivational dynamics affecting adherence. A review of 11 recent systematic reviews synthesized digital health technologies for medication adherence, identifying five key technologies that support PCC through enhanced symptom assessment, shared decision-making, and support optimized self-management, and improved communication with peers and providers. Three phases in the patient journey have been identified: diagnosis, medication start, and ongoing medication.

CONCLUSIONS

This study contributes qualitative insights to the realm of PCC, shifting away from a clinic-based fragmented approach towards a seamless experience incorporating digital health interventions in the medication journey. Digital technologies would better support patients to be fully informed about their illness and treatment, amplifying engagement in care activities and planning with good medication adherence.
Empirical Study on the Promotion of Industrial Structure Upgrading by Aviation Economy: A Case Study of National Airport Economic Zones
Authors: Li Sixian , Hu Yue , Xu Kuan , Miao Hanyu
Published: November 2024

With the rapid growth of civil aviation and economic integration, aviation economic zones centered on large airports have a significant economic impact on surrounding areas. These zones foster the concentration of technology, capital, and labor, leading to the emergence of new regional economic models. This research, based on data from 17 national-level aviation economic demonstration zones, develops an evaluation index system for aviation economic development and constructs a regression model incorporating industrial structure coefficients. It empirically analyzes the relationship between the development of aviation economy and the upgrading of industrial structure in cities with national-level aviation economic zones, revealing the aviation economy’s role in promoting industrial structure upgrading and providing policy recommendations for regional economic innovation.
Exploration of Business English Teaching Mode in Applied Undergraduate Colleges Based on OBE Concepts
Authors: Shan Yao
Published: November 2024

In the context of globalization, the demand for business English professionals is increasing, placing the application-oriented undergraduate institutions under the critical responsibility of cultivating business English graduates with practical abilities and professional competencies. However, the traditional teaching model tends to prioritize the impartation of linguistic knowledge, neglecting the cultivation of actual application skills, which fails to meet market demands. The Outcome-Based Education (OBE) philosophy, which is guided by learning outcomes and emphasizes the development of students' abilities, offers new insights for educational reform. This article reviews the current state of research on business English teaching models in application-oriented undergraduate institutions, highlighting the shortcomings of traditional models. Based on the OBE concept, this article explores the reconstruction of training objectives, the optimization of curriculum systems, the reform of teaching methods, and the improvement of evaluation systems as four core elements, and proposes implementation strategies involving strengthening top-level design, faculty development, school-enterprise cooperation, and information technology construction. These measures not only enhance the quality of education but also boost students' competitiveness in the workplace, providing valuable references for the reform of business English teaching models in application-oriented undergraduate institutions.
Digital Technology in English Language Learning: Opportunities, Challenges, and Innovations in India’s Education Landscape
Authors: Khan Filza Zaki , Ahmad S Anas
Published: November 2024

Against the background of India's multicultural society, this paper elucidates the progressive use of digital advancement in learning the English language. This research paper focuses on the opportunities for digital technologies in English learning in India and its progress and further growth. It reveals several technological possibilities encompassing the use of additional multimedia tools in learning, the generation/development of mobile applications for learners in urban and rural areas, their ability to choose according to their needs, and the provision of easy access to learning. The paper also highlights specific concerns in the Indian context of studying, namely the urgent need to address the digital access divide, lack of physical facilities, and socio-economic factors that limit people’s ability to apply technology for learning. This paper further outlines the emergence of transformative trends that are reshaping the landscape of English language education in India. These trends include the integration of Augmented Reality/Virtual Reality in language learning and teaching. The study provides a comprehensive understanding of the digital technologies that are revolutionising the acquisition of English in India, drawing on a systematic analysis of existing literature. The research findings underscore the critical challenges and issues that must be addressed to fully leverage the potential of digital transformation in enhancing English learning nationwide.
Ruta 9 - Guía de campo: Innovación Social en el Turismo de Intereses Especiales de la Región de Antofagasta
Authors: Ricci Emilio , Aracena-Escudero Carlos
Published: November 2024

Ruta 9 surge como aporte para la Región de Antofagasta y sus territorios, favoreciendo el desarrollo sostenible del Turismo de Intereses Especiales y considerando un sinnúmero de destinos emergentes y consolidados, y otros en desarrollo. Se acompaña al lector con indicaciones de algunos de los entornos naturales, patrimoniales y culturales de calidad. En fin, se trata de una publicación hecha con un especial interés por brindar a la comunidad en general, visitantes locales, forasteros o tour operadores una guía de campo con itinerarios variados y experiencias de visión interdisciplinaria en los atractivos naturales y patrimoniales de la Región. Se integran a los ejes de la IS ciertos productos con itinerarios que articulan diversos atractivos y que visibilizan entornos muy variados, donde la actividad transformadora de la infatigable acción del ser humano ha dejado huella en su búsqueda de oportunidades para mejorar su bienestar y aportar a la calidad de vida. De forma tácita, aparecen los efectos de la acción de sobrevivencia y resiliencia en las fronteras del desierto de Atacama, el más árido del mundo, que ha custodiado en su entorno natural la presencia de vida prístina. Se han recopilado e integrado diversas visiones en una acción de sistematización de variadas áreas de un conocimiento que es fruto del trabajo de investigadores y actores sociales que, incansablemente, han promovido la discusión y la observación de comunidades, entornos naturales y estrategias para enfrentar los desafíos del desarrollo y la sobrevivencia. También, la ubicación geográfica de cada una de las localidades señaladas, con sus hitos imperdibles y sus rutas incipientes, permite transitar en pocas páginas por las riquezas escénicas y sus proyecciones de transformación, así como observar sus valores históricos patrimoniales diseminados en un extenso perímetro geográfico. Este fue recorrido por los primeros habitantes de la costa, pueblos cazadores recolectores y, luego, por conquistadores, pirquineros, naturalistas, antropólogos, arqueólogos y religiosos, una infinidad de actores y gente motivada, algunos por la ambición o por la aventura, y otros en busca de oportunidades. Esto, junto a la inagotable abnegación personal, en beneficio —para algunos— del bien común, matiza y fortalece indudablemente las reflexiones y los contenidos de esta contribución de investigación aplicada, que nos complace presentar.
Inhibitory activity of nanoencapsulated quercetin against sodium arsenite-induced sub-acute liver toxicity in rats
Authors: Mandal Ardhendu Kumar , Sarkar Sibani , Ghosh Aparajita , Das Nirmalendu
Published: November 2024

Arsenic, a metalloid toxicant, is associated with a major global health problem as oxidative stress, a prime cause of tissue toxicity. The subject of our investigation was to assess the therapeutic efficiency of nanoencapsulated quercetin (QC) in combating sodium arsenite (NaAsO2)-inducted sub-acute hepatocellular toxicity in rat model. The rats of the hepatic damage group were injected subcutaneously (s.c.) four dosages of NaAsO2 (92.36 µM/kg b.wt.) twice a week. The rats of the polylactide nanoencapsulated QC group were injected intravenously (i.v.) four doses of nanoencapsulated QC (8.97 µmol/kg b.wt.) twice a week 2 h after the treatment (s.c.) with 92.36 µM /kg b. wt. NaAsO2 twice a week for four doses. The rats of the empty nanocasule or free QC treated group were injected i.v. four doses empty nanocapsule or free QC twice a week 2 h after the treatment (s.c.) with same doses of NaAsO2 twice a week for four doses. Arsenic deposition (580±20 µg/g protein) observed in liver tissue of rats treated with arsenite (92.36 µM/kg b.wt.), was found to reduce (120±9 µg/g protein) by the treatment of nanoencapsulated QC in rats significantly (p<0.001). The levels of antioxidant enzymes and GSSG/GSH ratio enhanced (p<0.001/0.1/0.01) by the treatment of NaAsO2 were reduced by the post treatment of nanoencapsulated QC significantly (p<0.001/0.01). The levels of ROS, lipohydroperoxide or membrane microviscosity increased or decreased (p<0.001) by the treatment of NaAsO2 were monitored to reduce or enhance significantly (p<0.001) by the treatment of nanoencapsulated QC in rat liver respectively. The blood serum biochemical levels enhanced (p<0.001) by the treatment of NaAsO2 were found to reduce significantly (p<0.001) by the treatment of nanoencapsulated QC in rats. The TGFβ1 and MMP-13 in the rat plasma augmented (p<0.001) by the treatment of NaAsO2-exposure were found to decline (p<0.001) significantly by the treatment of nanoencapsulated QC in rats. The rats in the other groups such as empty nanocapsule or free QC treated showed no or less inhibitory efficiency against NaAsO2-treatment compared to nanoencapsulated QC treated group. Application of nanoencapsulated QC may be a potent formulation to get higher inhibitory therapeutic efficiency against NaAsO2-induced sub-acute hepatocellular toxicity.
Evaluation of Proteinuria in Diabetic Patients Attending Gitwe District Hospital
Authors: ALAIN PRUDENCE ISHIMWE , Tharcisse GATEMBEZI , Donatien MUTABAZI , Marie Louise MUKAMANA , Jean Paul NSHUTI , Lauben HABIYAREMYE
Published: November 2024

Background: Proteinuria is a serious condition in which body proteins leak into urine due to kidney dysfunction nearly always caused by elevated serum glucose due to prolonged diabetes. Proteinuria occurs and affects individuals with diabetes, approximately 25% of diabetic patients may have proteinuria.
Aim: The aim of this study is to assess the levels of serum glucose and proteins in urine and their association in diabetic patients attending Gitwe District Hospital.
Methodology: The study population mainly comprised of diabetic patients, 110 study participants were included. Blood was drawn from finger for testing serum glucose using glucometer and urine samples were collected from diabetic patients and samples were analyzed in parasitology service using urine chemistry strips for proteins in urine testing.
Results: During data analysis, SPSS version 22 was used, the majority were female with 66.4% while 33.6% were male. The highest frequency of participants presented in this study were 27(24.6%) found in [43-52] years old. The mean age was 53 years ± 13.882 SD (ranged from 23 to 86 years). 53.7% had normal serum glucose level while 46.3% had high serum glucose level. However, 63.6% had no proteinuria while 20.0% had trace, 11.8% had mild and 4.6% had moderate proteinuria levels. Association between serum glucose and proteinuria was analyzed for statistical significance with Chi-square test and it was statistically significant as their p values were below 0.05(P-value of 0.000).
Conclusion: The study found that high serum glucose level leads to the presence of proteins in the urine. This study recommends regular monitoring of serum glucose levels, as well as routine urine tests to detect proteinuria as essential components of diabetes management and other researchers to study the effects of proteinuria in diabetic patients.
Keywords: Proteinuria, serum glucose, proteins, diabetic patients
EXTRACTION, Extraction, Isolation, Identification and Estimation of Diosgenin by TLC Profiling and UHPLC-LC-SRM Analysis in Three Costus Species
Authors: G M RADHA DEVI
Published: November 2024

Medicinal plants are utilized for treating many ailments, since ancient times due to their tremendous therapeutic properties. The plant derivatives are used as a raw material for the synthesis of drugs either as a natural or artificial synthetic drug. Costaceae family members are known to possess many medicinal properties few of them are mainly consumed to reduce the blood glucose level and treat many disorders. The sapogenin contained in the rhizome of three Costus species was extracted, identified, and characterized. Young rhizomes were harvested surface sterilized, hydrolyzed; extracted through a soxhlet apparatus and concentrated fractions were subjected to a preliminary phytochemical screening test for saponin, Thin Layer Chromatography, and the UHPLC-MS SRM analysis. The result showed that the maximum yield of the Diosgenin was obtained from the chloroform extract of Costus speciosus. The pharmaceutical analysis in all the three Costus species carried out with isolated saponin was compared with standard Diosgenin. The characterization of isolated diosgenin was done by UHPLC MS and SRM, based on the retention time of all three samples and the comparison with standard Diosgenin. Isolated Diosgenin was quantified through thin layer chromatography with n-hexane: ethyl acetate (7:3) as mobile phase at Rf value of 0.48. The amount of Isolated Diosgenin was estimated by comparing the peak area at a retention time Rt value of 8.5 in all the samples and compared with standard Diosgenin high amount of Diosgenin was found in Costus speciosus rhizome followed by Costus igneus and Costus pictus. The preliminary phytochemical screening and analytical methods involved during the present study were found satisfactory. Thus, the protocol can be used for the extraction of Diosgenin and further used in the synthesis of Drugs.
Keywords: Costus pictus, Costus speciosus, Costus igneus, rhizome, TLC, UHPLC-MS, SRM
Time to Cure and Predictive Factors Among Patients with Multi-Drug Resistance Tuberculosis in Puntland, Somalia: A Retrospective Cohort Study
Authors: Ali Mustafe Abdi , Ibrahim Ahmed Mohammed , Hussein Hassan Ahmed , Ibrahim Ahmed Mohammed
Published: November 2024

Background: Multi-drug-resistant tuberculosis, also known as MDR-TB, is caused by bacteria that are resistant to the most effective first-line anti-tuberculosis medications, which are rifampicin and isoniazid. MDR-TB is an increasing global concern, and its spread has varying cure times for patients affected. Thus, this study was intended to investigate the median time to cure and identify predictive factors for patients with MDR-TB in Puntland, Somalia.
Methods: A retrospective cohort study was carried out at the MDR-TB center in Galkayo, Puntland, Somalia between the years of July 2017 and August 2023. The study utilized data that were collected from the inquiry form and monitoring cards of a randomly selected sample of 130 patients over a 6-year period. The data were entered into Epi-Data version 4.3 and analyzed using R Programming version 4.4.0. Non-parametric methods were used to estimate the median time to cure for patients with MDR-TB. Semi-parametric and parametric models were employed to determine predictive factors that influence the time to cure for MDR-TB patients. The Akaike Information Criteria (AIC) and Bayesian Information Criteria (BIC) of different survival models were compared to select the model that offers the best fit.
Results: Out of the total of MDR-TB patients, 109(83.85%) were cured and 21(16.15%) were censored during the follow-up period. The median time to cure from MDR-TB was found to be 619 days which is approximately 20 months. In accordance with the AIC and BIC, the Log-logistic accelerated failure time model was the best fit for the data as compared to the other AFT models. The result of the Log-logistic AFT model revealed that age, sex, disease site, and comorbidities significantly affect the time to cure for MDR-TB. According to this study, older age with MDR-TB patients, male MDR-TB patients, MDR-TB patients with comorbid conditions, and extrapulmonary MDR-TB patients had a longer time to cure than their reference categories.
Conclusion: Based on the findings of the study, the median time to cure for patients with MDR-TB in Puntland was found to be 20 months. Sex, disease site, comorbidities and age were predictive factors of time to cure from MDR-TB.
Histopathological Alterations in Placentas of Severe and Non-Severe Preeclamptic Patients
Authors: Kaplan Şehmus , Karabat Mehmet Uğur , Atiç Esranur , Sancar Muhyiddin , Alkan İlkan , Aşır Fırat
Published: November 2024

Preeclampsia is a significant pregnancy complication associated with vascular lesions and trophoblastic invasion, leading to substantial maternal and fetal risks. This study compares histopathological changes in placental structures among severe and non-severe preeclamptic patients. Placental tissues were analyzed, revealing that preeclampsia groups showed notable villous degeneration, increased fibrin deposition, vascular dilatation, congestion, and syncytial node formation. Severe preeclampsia further exhibited intensified hemorrhage and leukocyte infiltration. These findings underscore the link between preeclampsia severity and placental dysfunction, providing insights into the pathological mechanisms affecting perinatal outcomes.
Keywords: placenta, preeclampsia, HELLP, histology
Histopathological Changes in Ovarian Tissues of Rats Underwent Ovarian Ischemia-Reperfusion Injury
Authors: Atiç Esranur , Sancar Muhyiddin , Karabat Mehmet Uğur , Kaplan Şehmus , Aşır Fırat , Akkuş Murat
Published: November 2024

This study investigates histopathological changes in ovarian tissues of rats subjected to ischemia-reperfusion (I/R) injury, a condition where restored blood flow causes cellular stress and potential damage. Rats were divided into three groups: control, ischemia, and ischemia-reperfusion. Histological analysis revealed that ischemic ovaries exhibited increased follicular degeneration, atretic follicles, and inflammatory infiltration. The ischemia-reperfusion group showed even more pronounced damage, including disrupted cellular structures and severe vascular congestion. These findings highlight the exacerbated tissue damage caused by reperfusion, underscoring the complex impact of I/R injury on ovarian tissue integrity.
Keywords: ovary, ischemia, reperfusion, histology
Formulation, Development and Evaluation of Pulsatile Tablets of Etoricoxib
Authors: Radke Rahul S. , Dhore Bharat B. , Pagore Ramesh R. , Biyani Kailash R.
Published: November 2024

Aim: This research aimed to develop a pulsatile drug delivery system (PDDS) for etoricoxib, selective COX-2 inhibitor analgesic, to address the limitations of conventional formulations by releasing the drug at specific intervals aligned with the circadian rhythm of pain.
Method: Core tablets containing Etoricoxib were prepared by direct compression with varied concentrations of croscarmellose sodium as a superdisintegrant. The optimized core tablets were coated using hydrophilic (HPMC K4M) and hydrophobic (ethyl cellulose) polymers in different ratios to create press-coated pulsatile tablets with varying lag times. Physical properties hardness, thickness, friability, and disintegration, drug content uniformity, and in vitro release were evaluated.
Results: The core tablets exhibited rapid drug release, with batch C3 showing 98.61% release within 60 minutes. Press-coated formulations with different polymer ratios exhibited varying lag times, with batch F3 achieving the optimal balance—providing a 4-hour lag time and 96.6% drug release over 8 hours. Stability studies confirmed the physical and chemical stability of the optimized formulation (F3) over 6 months under accelerated conditions.
Conclusion: The developed press-coated pulsatile tablets of etoricoxib successfully achieved a controlled lag time and sustained drug release profile, making them suitable for chronopharmacological management of pain.
Keywords: Etoricoxib, Pulsatile Drug Delivery System, Chronopharmacology, Press-Coated Tablets. etc
Monte Carlo Simulation of Organ Absorbed Dose of Worker's Radiation Exposure in Bone Scintigraphy
Authors: Charles Kouman Koffi , N’guessan Placide Gabin Allangba Koffi , Fagnidi Yves Kily Hervé , Guy Müller Banquet Okra
Published: November 2024

Objectives: This study examines individual organ doses and the impact of ionizing radiation sources on effective radiation doses.
Methods: In the research, the ICRP-defined adult standing phantom was used as the phantom material in the Visual Monte Carlo Dose Calculation Program (VMC). Subsequently, the incurred doses were calculated by defining different doses, distances, and durations for the 99mTc radioactive source.
Results: Exposure times were set at 5 minutes and 20 minutes in comparison. The results indicated that for 5 minutes and 20 minutes at 360 cm, doses remained below the ICRP recommended annual dose limit of 5.7 µSv/h for occupational exposure.
Conclusion: Organ absorbed and effective doses varied with exposure time and source-phantom distance. To optimize radiation exposure, people working in radiation fields must make an increased effort to reduce radiation doses following the ALARA principles.
Keywords: Effective dose, absorbed dose, VMC software, Monte Carlo