bluuebunny/crossref_metadata_2025 huggingface dataset:
Atmospheric River Representation in the Energy Exascale Earth System Model (E3SM) Version 1.0
Authors: Kim Sol , Leung L. Ruby , Guan Bin , Chiang John C. H.
Published: November 2021

Abstract. The Energy Exascale Earth System Model (E3SM) Project is an ongoing, state-of-the-science Earth system modeling, simulation, and prediction project developed by the U.S. Department of Energy (DOE). With an emphasis on supporting DOE's energy mission, understanding and quantifying how well the model simulates water cycle processes is of particular importance. Here, we evaluate E3SM version v1.0 for its ability to represent atmospheric rivers (ARs), which play significant roles in water vapor transport and precipitation. The characteristics and precipitation associated with global ARs in E3SM at standard resolution (1° × 1°) are compared to the Modern-Era Retrospective analysis for Research and Applications, Version 2 (MERRA2). Global pattern of AR frequencies in E3SM show high degrees of correlation (>= 0.97) with MERRA2 and low mean absolute errors (< 1 %) annually, seasonally, and across different ensemble members. However, some large-scale condition biases exist leading to AR biases - most significant of which are: the double-ITCZ, a stronger and/or equatorward shifted subtropical jet during boreal and austral winter, and enhanced northern hemisphere westerlies during summer. By comparing atmosphere-only and fully coupled simulations, we attribute the sources of the biases to the atmospheric component or to a coupling response. Using relationships revealed in Dong et al. (2021), we provide evidence showing the stronger north Pacific jet in winter and enhanced northern hemisphere westerlies during summer associated with E3SM's double-ITCZ and related weaker AMOC, respectively, are the sources of much of the AR biases found in the coupled simulations.
Impact of changes in climate and CO2 on the carbon-sequestration potential of vegetation under limited water availability using SEIB-DGVM version 3.02
Authors: Tong Shanlin , Wang Weiguang , Chen Jie , Xu Chong-Yu , Sato Hisashi , Wang Guoqing
Published: November 2021

Abstract. Documenting year-to-year variations in carbon-sequestration potential in terrestrial ecosystems is crucial for the determination of carbon dioxide (CO2) emissions. However, the magnitude, pattern and inner biomass partitioning of carbon-sequestration potential, and the effect of the changes in climate and CO2 on inner carbon stocks, remain poorly quantified. Herein, we use a spatially explicit individual based-dynamic global vegetation model to investigate the influences of the changes in climate and CO2 on the enhanced carbon-sequestration potential of vegetation. The modelling included a series of factorial simulations using the CRU dataset from 1916 to 2015. The results show that CO2 predominantly leads to a persistent and widespread increase in above-ground vegetation biomass carbon-stocks (AVBC) and below-ground vegetation biomass carbon-stocks (BVBC). Climate change appears to play a secondary role in carbon-sequestration potential. Importantly, with the mitigation of water stress, the magnitude of the above- and below-ground responses in vegetation carbon-stocks gradually increases, and the ratio between AVBC and BVBC increases to capture CO2 and sunlight. Changes in the pattern of vegetation carbon storage was linked to regional limitations in water, which directly weakens and indirectly regulates the response of potential vegetation carbon-stocks to a changing environment. Our findings differ from previous modelling evaluations of vegetation that ignored inner carbon dynamics and demonstrates that the long-term trend in increased vegetation biomass carbon-stocks is driven by CO2 fertilization and temperature effects that are controlled by water limitations.
Revisiting parameter sensitivities in the Variable Infiltration Capacity model
Authors: Sepúlveda Ulises , Mendoza Pablo A. , Mizukami Naoki , Newman Andrew J.
Published: November 2021

Abstract. Despite the Variable Infiltration Capacity (VIC) model being used for decades in the hydrology community, there are still model parameters whose sensitivities remain unknown. Additionally, understanding the factors that control spatial variations in parameter sensitivities is crucial given the increasing interest to obtain spatially coherent parameter fields over large domains. In this study, we investigate the sensitivities of 43 soil, vegetation and snow parameters in the VIC model for 101 catchments spanning the diverse hydroclimates of continental Chile. We implement a hybrid local-global sensitivity analysis approach, using eight model evaluation metrics to quantify sensitivities, with four of them formulated from runoff time series; two characterizing snow processes, and the remaining two based on evaporation processes. Our results confirm an over-parameterization for the processes analysed here, with only 12 (i.e., 28 %) parameters found as sensitive, distributed among soil (7), vegetation (2) and snow (3) model components. Correlation analyses show that climate variables – in particular, mean annual precipitation and aridity index – are the main controls on parameter sensitivities. Additionally, our results highlight the influence of the leaf area index on simulated hydrologic processes – regardless on the dominant climate types – and the relevance of hard-coded snow parameters. Based on correlation results and the interpretation of spatial sensitivity patterns, we provide guidance on the most relevant parameters for model calibration according to the target processes and the prevailing climate type. Overall, the results presented here contribute to improved understanding of model behaviour across watersheds with diverse physical characteristics that encompass a wide hydroclimatic gradient from hyper-arid to humid systems.
Socio-hydrological modeling of the tradeoff between flood control and hydropower provided by the Columbia River Treaty
Authors: Shrestha Ashish , Augusto Arguello Souza Felipe , Park Samuel , Cherry Charlotte , Garcia Margaret , Yu David J. , Mario Mendiondo Eduardo
Published: November 2021

Abstract. The Columbia River Treaty (CRT) signed between the United States and Canada in 1961 is known as one of the most successful transboundary water treaties. Under continued cooperation, both countries equitably share collective responsibilities of reservoir operations, and flood control and hydropower benefits from treaty dams. As the balance of benefits is the key factor of cooperation, future cooperation could be challenged by external social and environmental factors which were not originally anticipated, or change in the social preferences of the two actors. To understand the robustness of cooperation dynamics we address two research questions – i) How does social and environmental change influence cooperation dynamics? and ii) How do social preferences influence the probability of cooperation for both actors? We analyzed infrastructural, hydrological, economic, social, and environmental data to inform the development of a socio-hydrological system dynamics model. The model simulates the dynamics of flood control and hydropower benefit sharing as a function of the probability to cooperate, which in turn is affected by the share of benefits. The model is used to evaluate scenarios that represent environmental and institutional change, and changes in political characteristics based on social preferences. Our findings show that stronger institutional capacity ensures equitable sharing of benefits over the long term. Under current CRT, the utility of cooperation is always higher for Canada than non-cooperation which is in contrast to the U.S. The probability to cooperate for each country is lowest when they are self-interested but fluctuates in other social preferences scenarios.
Slow build-up of turbidity currents triggered by a moderate earthquake in the Sea of Marmara
Authors: Henry Pierre , Özeren Sinan , Yakupoğlu Nurettin , Çakir Ziyadin , de Saint-Léger Emmanuel , Desprez de Gésincourt Olivier , Tengberg Anders , Chevalier Cristele , Papoutsellis Christos , Postacıoğlu Nazmi , Dogan Uğur , Karabulut Hayrullah , Uçarkuş Gülsen , Çağatay M. Namık
Published: November 2021

Abstract. Earthquake-induced submarine slope destabilization is known to cause debris flows and turbidity currents, but the hydrodynamic processes associated with these events remain poorly understood. Records are scarce and this notably limits our ability to interpret marine paleoseismological sedimentary records. An instrumented frame comprising a pressure recorder and a Doppler recording current meter deployed at the seafloor in the Sea of Marmara Central Basin recorded consequences of a MW = 5.8 earthquake occurring Sept 26, 2019 and of a Mw = 4.7 foreshock two days before. The smaller event caused sediment resuspension but no strong current. The larger event triggered a complex response involving a mud flow and turbidity currents with variable velocities and orientations, which may result from multiple slope failures. A long delay of 10 hours is observed between the earthquake and the passing of the strongest turbidity current. The distance travelled by the sediment particles during the event is estimated to several kilometres, which could account for a local deposit on a sediment fan at the outlet of a canyon, but not for the covering of the whole basin floor. We show that after a moderate earthquake, delayed turbidity current initiation may occur, possibly by ignition of a cloud of resuspended sediment. Some caution is thus required when tying seismoturbidites with earthquakes of historical importance. However, the horizontal extent of the deposits should remain indicative of the size of the earthquake.
Modeling of a compound flood induced by the levee breach at Qianbujing Creek, Shanghai, during Typhoon Fitow
Authors: Yang Yuhan , Yin Jie , Zhang Weiguo , Zhang Yan , Lu Yi , Liu Yufan , Xiao Aoyue , Wang Yunxiao , Song Wenming
Published: November 2021

Abstract. Levee-breach-induced flooding occurs occasionally but always
causes considerable losses. A serious flood event occurred due to the
collapse of a 15 m long levee section in Qianbujing Creek, Shanghai, China,
during Typhoon Fitow in October 2013. Heavy rainfall associated with the typhoon
intensified the flood severity (extent and depth). This study investigates
the flood evolution to understand the dynamic nature of flooding and the
compound effect using a well-established 2D hydro-inundation model
(FloodMap) to reconstruct this typical event. This model coupled urban
hydrological processes with flood inundation for high-resolution flood
modeling, which has been applied in a number of different environments, and
FloodMap is now the mainstream numerical simulation model used for flood
scenarios. Our simulation results provide a comprehensive view of the
spatial patterns of the flood evolution. The worst-hit areas are predicted
to be low-lying settlements and farmland. Temporal evaluations suggest that
the most critical time for flooding prevention is in the early
1–3 h after dike failure. In low-elevation areas,
temporary drainage measures and flood defenses are equally important. The
validation of the model demonstrates the reliability of the approach.
Inclusion of biochar in a C-dynamics model based on observations from a 8 years field experiment
Authors: Pulcher Roberta , Balugani Enrico , Ventura Maurizio , Marazza Diego
Published: November 2021

Abstract. Biochar production and application as soil amendment is a promising carbon (C) negative technology to increase soil C sequestration and mitigate climate change. However, there is a lack of knowledge about biochar degradation rate in soil and its effects on native soil organic carbon (SOC), mainly due to the absence of long term experiments performed in field conditions. The aim of this work was to investigate the long term degradation rate of biochar in a field experiment of 8 years in a poplar short rotation coppice plantation in Piedmont (Italy), and to modify the RothC model to assess and predict how biochar influences soil C dynamics. The RothC model was modified by including two biochar pools, labile (4 % of the total biochar mass) and recalcitrant (96 %), and the priming effect of biochar on SOC. The model was calibrated and validated using data from the field experiment. The results confirm that biochar degradation can be faster in field conditions in comparison to laboratory experiments; nevertheless, it can contribute to substantially increase the soil C stock in the long-term. Moreover, this study shows that the modified RothC model was able to simulate the dynamics of biochar and SOC degradation in soils in field conditions in the long term, at least in the specific conditions examined.
Two decades of dynamic change and progressive destabilization on the Thwaites Eastern Ice Shelf
Authors: Alley Karen E. , Wild Christian T. , Luckman Adrian , Scambos Ted A. , Truffer Martin , Pettit Erin C. , Muto Atsuhiro , Wallin Bruce , Klinger Marin , Sutterley Tyler , Child Sarah F. , Hulen Cyrus , Lenaerts Jan T. M. , Maclennan Michelle , Keenan Eric , Dunmire Devon
Published: November 2021

Abstract. The Thwaites Eastern Ice Shelf (TEIS) buttresses the eastern grounded portion of Thwaites Glacier through contact with a pinning point at its
seaward limit. Loss of this ice shelf will promote further acceleration of Thwaites Glacier. Understanding the dynamic controls and structural
integrity of the TEIS is therefore important to estimating Thwaites' future sea-level contribution. We present a ∼ 20-year record of change on
the TEIS that reveals the dynamic controls governing the ice shelf's past behaviour and ongoing evolution. We derived ice velocities from MODIS and
Sentinel-1 image data using feature tracking and speckle tracking, respectively, and we combined these records with ITS_LIVE and GOLIVE velocity
products from Landsat-7 and Landsat-8. In addition, we estimated surface lowering and basal melt rates using the Reference Elevation Model of Antarctica (REMA) DEM in comparison to ICESat and
ICESat-2 altimetry. Early in the record, TEIS flow dynamics were strongly controlled by the neighbouring Thwaites Western Ice Tongue (TWIT). Flow
patterns on the TEIS changed following the disintegration of the TWIT around 2008, with a new divergence in ice flow developing around the
pinning point at its seaward limit. Simultaneously, the TEIS developed new rifting that extends from the shear zone upstream of the ice rise and
increased strain concentration within this shear zone. As these horizontal changes occurred, sustained thinning driven by basal melt reduced ice
thickness, particularly near the grounding line and in the shear zone area upstream of the pinning point. This evidence of weakening at a rapid pace
suggests that the TEIS is likely to fully destabilize in the next few decades, leading to further acceleration of Thwaites Glacier.
Understanding model spread in sea ice volume by attribution of model differences in seasonal ice growth and melt
Authors: West Alex , Blockley Ed , Collins Mat
Published: November 2021

Abstract. Arctic sea ice is declining rapidly, but predictions of its future loss are made difficult by the large spread both in present-day and in future sea ice area and volume; hence, there is a need to better understand the drivers of model spread in sea ice state. Here we present a framework for understanding differences between modelled sea ice simulations based on attributing seasonal ice growth and melt differences. In the method presented, the net downward surface flux is treated as the principal driver of seasonal sea ice growth and melt. A system of simple models is used to estimate the pointwise effect of model differences in key Arctic climate variables on this surface flux, and hence on seasonal sea ice growth and melt. We compare three models with very different historical sea ice simulations: HadGEM2-ES, HadGEM3-GC3.1 and UKESM1.0. The largest driver of differences in ice growth / melt between these models is shown to be the ice area in summer (representing the surface albedo feedback) and the ice thickness distribution in winter (the thickness-growth feedback). Differences in snow and melt-pond cover during the early summer exert a smaller effect on the seasonal growth and melt, hence representing the drivers of model differences in both this and in the sea ice volume. In particular, the direct impacts on sea ice growth / melt of differing model parameterisations of snow area and of melt-ponds are shown to be small but non-negligible.
Identifying Challenges and Solutions to Providing Diabetes Care for Those Experiencing Homelessness
Authors: Mancini Nicole , Campbell Rachel , Yaphe Hannah , Tibebu Tadios , Grewal Eshleen , Saunders-Smith Terry , McBrien Kerry , Campbell David
Published: November 2021

Introduction: Health care providers face a multitude of challenges in providing care to patients with diabetes who are experiencing homelessness. Considering the unique circumstance faced by this population, mainstream services must be adapted and tailored to meet patients’ needs. The objective of this study was to explore both the barriers faced by providers and programs in offering comprehensive diabetes care to these patients, and their suggested areas for improvement.
Methods: We conducted semi-structured interviews with providers who care for patients who have diabetes and/or who experience homelessness. Participants included primary care providers, specialist physicians, dietitians, shelter staff, outreach workers, and diabetes educators in five Canadian centres (n=96). Responses were analyzed using qualitative thematic analysis.
Results: Barriers most frequently cited by providers were a lack of resources for staff. Other challenges included policy barriers (restrictions on billing codes, care professionals’ scope of practice, and the structure of financial support for this population), duplication of services, and alternative priorities of care. Participants identified several strategies to improve care, which targeted the following spheres: location of service provision and coordination of care, policy changes, and extending funding and resources for staff, such as augmented funding to hire allied health professionals in outpatient settings and increasing outreach capabilities.
Conclusion: Programs that strive to address the unique needs of clients experiencing homelessness face numerous challenges. Unique potential solutions to these barriers, such as service provision in a convenient location involving social and health services, incorporating allied health care providers in care to a greater extent, and updating policies to reflect the social complexity of the population can improve diabetes care.
Criança e infância na obra de Philippe Ariès e nos clássicos da História Social da Classe Operária: em busca das crianças invisíveis – as crianças proletárias
Authors: Hermida Jorge Fernando
Published: November 2021

Neste artigo revelamos o lugar que as crianças proletárias tiveram nas representações dos conceitos de criança e de infância nos séculos XVII, XVIII e XIX na Europa, especialmente na obra de Philippe Ariès, pioneiro em pesquisar essa temática, ainda que, na sua obra seminal História social da criança e da família (2015), não tenhamos localizado nenhuma referência aos filhos da classe trabalhadora. Entretanto, a criança proletária teve presença social preponderante nas obras dos autores da História Social da Classe Operária, como será mostrado ao longo do texto, as quais abordavam a revolução industrial e a consolidação da formação social capitalista. Trata-se de uma pesquisa histórica e documental, com base em uma interpretação marxista da história. O artigo conclui que as representações de criança e infância de Ariès (2015) foram feitas com base em crianças pertencentes às classes dominantes da época (da nobreza e da aristocracia). Essas representações dos filhos das classes mais abastadas eram bem diferentes e bem distantes da efervescente vida social e da limitada vida material do resto das crianças – as crianças proletárias, que eram covardemente exploradas pelo capitalismo nos campos, nas fábricas, nas olarias e nas minas de carvão.
Crianças pequenas na escola: contradições e potencialidades
Authors: Pasqualini Juliana , Lazaretti Lucineia
Published: November 2021

Na sociedade capitalista contemporânea a atividade social da criança pequena encontra-se largamente situada no interior de instituições de educação infantil. Este artigo recupera as origens e o desenvolvimento histórico das instituições de educação infantil, analisando as necessidades societárias concretas em função das quais essa prática social se instituiu e institucionalizou-se. Nesse percurso, evidencia que a consolidação da educação infantil como prática institucional respondeu historicamente a motivações extrínsecas, essencialmente econômicas e ideológicas, ao mesmo tempo que abriu a possibilidade histórica de converter em objeto de pesquisa e debate social as melhores condições possíveis para o desenvolvimento e a educação da criança pequena. Refletir sobre a escola de educação infantil como conquista histórica que, embora não isenta de contradições, contém a potencialidade de enriquecer a formação humana da criança, é a proposta desse ensaio, que problematiza as concepções de desenvolvimento infantil e de criança subjacentes aos projetos historicamente em disputa para etapa educacional. A aposta no ensino desenvolvente é o caminho que se indica como potencialidade de a escola de educação infantil constituir-se como espaço de atividades significativas e formativas para as crianças até os cinco anos de idade.
Literatura surda: traduzindo histórias de vidas singulares
Authors: Silva Márcia Rios da , Penha Jéssica Gabriela da Silva
Published: November 2021

A literatura surda emergente vem se destacando pela adaptação de histórias “originais” em paralelo a uma escrita autoral crescente. Na reescrita dessas produções originais, os surdos ganham visibilidade como sujeitos ativos e participativos no espaço social e cultural (PERLIN). Sob essa formação de apropriação cultural, a literatura surda assume o compromisso com a tematização de situações e sentimentos enfrentados pelo indivíduo surdo (GAVA), trazendo à tona o desejo de reconhecimento e reafirmação de identidades. Considerando o público ao qual se destinam às referidas adaptações, o presente artigo tem por objetivo proceder a uma reflexão sobre esta prática tradutória em que questões temáticas e formais são passíveis de atualização e recriação. Nesta análise, busca-se apoio nas contribuições de Marinyse Oliveira, Lodenir Karnopp e Linda Hutcheon, que postulam que os processos de adaptação e tradução estão imbricados e resultam em um trabalho de criação.
A variação da lateral pós-vocálica  na escrita de alunos: a posição da sílaba e a vogal precedente
Authors: Silva Laiane Thaís de Oliveira , Oliveira Josane Moreira de
Published: November 2021

Analisa-se a variação da escrita da lateral pós-vocálica por alunos do 3º e do 5º anos de duas escolas de Riachão do Jacuípe-BA. Foram documentadas as variantes e , o rótico , o apagamento e a manutenção do . São analisadas, de acordo com os pressupostos teórico-metodológicos da Sociolinguística Variacionista, duas variáveis que influenciam a representação escrita dessa consoante: a posição da sílaba e a vogal precedente. Os resultados atestam que alunos em processo de aquisição da escrita, por não dominarem completamente as normas ortográficas, transpõem a fala para a escrita.
Optimization of PLGA nanoparticles for delivery of Novel anticancer
CK-10 peptide
Authors: Samuel Girgis , Nazim Uddin , Srag El-Din Ahmed S.G.
Published: November 2021

The main objective of this project was to formulate novel amphiphilic PLGA nanoparticles having better physicochemical properties for the delivery of the novel peptide (CK-10) to be used for targeting the cancerous/tumour tissue. Double emulsion/Solvent evaporation and novel microfluidic techniques were used to formulate the nanoparticles. Loading efficiency and in-vitro release were measured by a modified Lowry assay. Size and zeta potential were characterized by dynamic light scattering, tuneable pore resistive sensing, and laser obscuration time. Images were scanned by scanning, transmission electron microscopes, and laser obscuration time. Stability was checked by high-performance liquid chromatography and capillary zone electrophoresis. Water absorption and its associated changes in the physicochemical properties were measured by various titration techniques. PLGA/Poloxomer nanoparticles had the highest peptide loading efficiency by 56.13 % for the novel microfluidic technique as well as the highest in-vitro release and water absorption values. It also had the smallest size with the lowest PDI (208.90 nm, 0.11) which are vital parameters for targeting cancer/tumour tissue. The successful development of better physicochemical properties for the CK-10 loaded PLGA nanoparticles could improve the RAN blocking by CK-10.
Formulation and Development of Metoprolol Succinate Sustained Release Matrix tablet using Remusatia vivipara tubers mucilage
Authors: Sharma Ganesh N. , Bhurat Mayur R. , Shastry Vijay M. , Shrivastava Birendra
Published: November 2021

The purpose of this research was to formulate and evaluate sustained release tablet by using novel polymer Remusatia vivipara tubers mucilage. Currently natural gums and mucilages are being used extensively comparable to synthetic drug release modifiers. Natural plant materials possess various advantages. These are very cheap, biocompatible, biodegradable and free from side effects. In present research Metoprolol succinate matrix tablets were prepared by using Remusatia vivipara tubers mucilage. For the formulation of sustained release matrix tablets, direct compression method was used. The formulated matrix tablets were then evaluated for thickness, diameter, hardness, weight variation, friability, drug content, swelling index, in-vitro drug release and stability studies. The formulated sustained release tablet passed all tests required. The dissolution profile of prepared tablets showed sustained release of drug up to 11 hours compared to the reference tablet formulation PROLOMET XI 100. Drug release data were then fitted in to release kinetic models such as zero order kinetic, first order kinetic, Higuchi model and Korsmeyer-Peppas model to study the release pattern of drug from each formulation. The prepared sustained release tablet formulation was compared with marketed formulation (reference formulation) for drug release study and factor f1 (difference factor) and f2 (similarity factor) were determined. From this study it can be concluded that as the concentration of Remusatia vivipara mucilage increases, there is decrease in the rate of drug release from the formulation. The best formulation was found to be F3 which consists of 20% Remusatia vivipara mucilage but did not give comparable drug release profile to the reference formulation with factor f1 69.4 % and f2 34.8%. But it can be said that Remusatia vivipara gum mucilage can be used in tablet formulation to give sustained release effect up to 10 hours or in combination with other natural gum mucilage it may enhance the release retardant effect of drug up to or more than 20 hrs. The release kinetic study showed that the prepared sustained release tablet formulation shows anomalous (non-fickian) diffusion pattern and follows both diffusion controlled and swelling controlled mechanisms for drug release.
Validation UV Spectrophotometric Method to Determine Entrapment Efficiency of Ocular Polymeric Nanoparticle Levofloxacin Hemihydrate
Authors: Maharini Indri , Martien Ronny , Nugroho Akhmad Kharis , Supanji Supanji , Adhyatmika Adhyatmika
Published: November 2021

Simple, easy, and economical UV spectrophotometric methods have been developed using simulated tear fluid (STF) solvent to determine levofloxacin hemihydrate (LEVH) levels in ocular nanoparticles, as indicated by the % entrapment efficiency. A maximum wavelength of levofloxacin at 288nm, with a 4.0-12.0µg/mL concentration, shows linear results with a correlation coefficient (r) of 0.9997 and an average % recovery of 99.920 –100.804%. The developed method is able to use for the analysis of levofloxacin hemihydrate in nanoparticle preparations.
A Case Report on Methimazole Induced Anti-Thyroid Arthritis Syndrome: A Rare Drug Induced Migratory Polyarthritis
Authors: Mohan Aiswarya , H Aravind , Maddipati Chakravarthy S , P R Roshni
Published: November 2021

Antithyroid drugs (ATD’s) are widely used as the first line treatment option for the management of hyperthyroidism, especially for patients with Graves’ disease. They are classified into thionamide (Methimazole, Carbimazole and Propylthiouracil) and Non-thionamide (Iodine containing compounds) ATD’s. These drugs are associated with various types of adverse effects ranging from mild to potentially life threatening. Antithyroid arthritis syndome (AAS) is one of the major and uncommon side effects of ATD therapy requiring immediate drug discontinuation and hospitalization presents itself with myalgia, arthralgia and arthritis along with fever and rash of varying severity and non-specific laboratory findings, making its diagnosis and management clinically challenging. Here we report the case of 32 year old female with Graves’ disease who experienced severe migratory polyarthritis after the initiation of methimazole therapy. Her symptoms started to disappear after the prompt withdrawal of methimazole. We also concluded that this adverse effect of ATD’s might not be dose dependent by comparing our case with 6 other case reports of AAS. Here our objective is to raise awareness among the clinicians regarding the differential diagnosis and management of this major, uncommon and potentially life threatening adverse effect of ATD therapy.
RP-HPLC Method for Quantification of Etelcalcetide in Bulk and Parentral Dosage Form
Authors: Adireddy Krishna Kishore , Baratam Srinivasa Rao , Pratap S. Nagarjuna Hari
Published: November 2021

A simple, rapid, accurate and precise RP-HPLC method was developed and validated for the determination of Etelcalcetide in bulk and parentral dosage form. Quantification of the drug was achieved on Shimadzu HPLC comprising of LC- 20 AD binary gradient pump, a variable wavelength programmable SPD-20A detector and SCL system controller. C18G column (250 mm x 4.6 mm, 5 μ) as stationary phase with mobile phase consisting of acetonitrile: methanol :water in the ratio of 25: 45 :30 v/v. The method showed a good linear response in the concentration range of 3.75-22.5 μg/ml with correlation coefficient of 0.9999. The flow rate was maintained at 1.0 ml/min and effluents were monitored at 238 nm. The retention time of etelcalcetide was 6.201 min. The method was statistically validated for accuracy, precision, linearity, ruggedness, robustness, solution stability, selectivity and sensitivity. The results obtained in the study were within the limits of ICH guidelines and hence this method can be used for the determination of etelcalcetide in bulk and parentral dosage form.
The Specific Anti-cancerous Mechanisms Suggesting Spirulina Alga as a Promising breast Cancer Fighter
Authors: Fayyad Raghad J. , Mohammed Ali Alaa Naseer , Hamdan Noor T.
Published: November 2021

Breast cancer is the most widely recognized and leading to global death incidences among women, traditional medications employ herbal sources in both prevention and dealing strategies of this lethal disease. It is well known that Patients suffering from cancer use plant derived therapy to complement or as alternatives for standard treatment .Strong anti-proliferative effects against cancer cell line by using Spirulina was explained previously by many researchers, thus, in current review authors elucidate the excite cellular mechanisms, involving with anti-proliferative effect of several constituents (phycocyanin, polysaccharides, flavonoids, resins, saponins and alkaloids) which have detected within this alga .these mechanisms include: inter action within the immune system, DNA repair, apoptosis induction as well as antioxidant property. The selection to focus on breast cancer treatment; is the widely spread of this type of cancer among Iraqi women through the last decades the current review give a possible and a promising insight of using this alga as a natural, cheap source in management of this lethal challenge.
Nghiên cứu xây dựng điểm chuẩn cho bài kiểm tra dựa trên sự kết hợp của T-GM(m,n), GRA và phương pháp ROC
Authors: Nguyễn Phước Hải , Trịnh Thị Kim Bình , Tạ Phương Hùng
Published: November 2021

Mục đích của nghiên cứu này là đề xuất xây dựng điểm chuẩn cho bài kiểm tra dựa trên sự kết hợp của T-GM(m,n), GRA và phương pháp ROC. Ngoài ra, người nghiên cứu đã sử dụng phần mềm MATLAB để thiết kế một hộp công cụ MATLAB cho phương pháp này. Kết quả nghiên cứu này đã cho thấy rằng phương pháp này không chỉ có thể xây dựng được điểm chuẩn cho bài kiểm tra, mà còn cung cấp cho các nhà giáo dục một phương pháp hiệu quả để đánh giá, phân loại và dự báo kết quả học tập của học sinh.
Các yếu tố ảnh hưởng đến nợ xấu của hệ thống ngân hàng thương mại Việt Nam
Authors: Nguyễn Thành Đạt
Published: November 2021

Nghiên cứu phân tích số liệu của 23 ngân hàng thương mại cổ phần Việt Nam từ năm 2009 – 2017, để kiểm định tác động của các yếu tố ảnh hưởng đến tỷ lệ nợ xấu của các ngân hàng thương mại cổ phần. Sử dụng phương pháp hồi quy tác động cố định (FE) và tác động ngẫu nhiên (RE). Nghiên cứu thấy rằng tỷ lệ nợ xấu của các ngân hàng ở năm trước càng cao sẽ làm cho tỷ lệ nợ xấu của ngân hàng hiện tại càng gia tăng. Đồng thời, ngân hàng có chi phí trích lập dự phòng càng cao thì nợ xấu càng cao. Từ kết quả nghiên cứu, tác giả đề xuất một số ý kiến nhằm cải thiện tỷ lệ nợ xấu của các ngân hàng thương mại cổ phần.
Nghiên cứu diễn biến một vài chỉ số y sinh học của vận động viên đội tuyển bóng chuyền nam Trường Đại học Sư phạm Thể dục thể thao Thành phố Hồ Chí Minh sau một năm tập luyện
Authors: Phan Thanh Việt , Nguyễn Hoàng Minh , Huỳnh Trọng Khải
Published: November 2021

Sử dụng các thử nghiệm y sinh thể thao để thu thập và phân tích diễn biến một vài chỉ số y sinh học thuộc hệ hô hấp, hệ tim mạch, tâm lý - thần kinh gắn liền với những chỉ số hình thái cơ thể của vận động viên bóng chuyền nam Trường Đại học Sư phạm Thể dục thể thao Thành phố Hồ Chí Minh sau một năm tập luyện. Kết quả nghiên cứu cho thấy có 8 chỉ số y sinh học diễn biến theo hướng tích cực, tạo sự khác biệt có ý nghĩa thống kê (P<0,05). Cụ thể là (1) Tần số nhịp tim, (2) Huyết áp tối đa, (3) Huyết áp tối thiểu, (4) Huyết áp trung bình, (5) Chỉ số công năng tim, (6) Chỉ số PWC170, (7), Chỉ số VO2max tuyệt đối, (8) Phản xạ đơn. Trong đó, nổi bật là chỉ số PWC170 diễn biến từ mức Trung bình lên mức Tốt và thời gian đáp ứng phản xạ đơn cải thiện từ mức Trung bình lên mức Khá sau một năm tập luyện.
Less is more
Authors: Wentzel Arnold
Published: November 2021

Pedagogical practices that are effective in content courses are often effective in CLIL courses too, yet one such practice – content compression – is generally neglected. Content compression is the purposeful reduction of the content to be taught; however, the CLIL literature often warns against the reduction and simplification of content for fear that it might harm students’ understanding of the subject content. This paper explains the ostensibly paradoxical result that content compression improves students’ understanding of content and shows why it is well suited to CLIL, if applied correctly. It presents content compression principles and techniques that are appropriate to content production and teaching practice in the CLIL classroom and shows how it was used to enhance language acquisition by students in a CLIL business course at a Colombian university over a period of three semesters. This experience suggested that content compression, in combination with other pedagogical practices, not only increased students’ linguistic confidence, but also enhanced their perceived learning in both content and language.
A Case Study of Three Finnish Pre-Service Teachers’ Emotions and Understanding of CLIL During an Online Practicum
Authors: Pappa Sotiria
Published: November 2021

The novel exigencies of the 2020 COVID-19 pandemic caused a shift towards online learning environments and teleconference platforms, which have also affected teaching practicums. The impact of this approach on teacher preparation is yet unknown and may render pre-service teachers (PSTs) more vulnerable to the challenges of early professional learning through practice, especially when implementing a methodology they have been insufficiently introduced to. Following three students of primary teacher education who opted for a practicum in a CLIL class at a Finnish teacher training school, this case study examines how the online practicum affected these PSTs’ emotions and understanding of CLIL. The case study is based on the analytical categories of teacher identity and emotion and draws on essay, diary, and interview data. The thematic analysis of the data suggests that the online practicum met participants’ expectations for building confidence and was perceived as an overall instructive experience, which was improved by the quality of mentorship and peer support they received. However, feelings of frustration or dissatisfaction accompanied moments of conflict with incoming expectations, principally related to using English in CLIL. The analysis further suggests that the online practicum strengthened participants’ earlier conception of CLIL as a language-oriented teaching tool. Regardless of whether online CLIL practicums remain a future option, acquiring disciplinary and language knowledge alike are important aspects in teacher preparation for CLIL, which could be an optional part of teacher education programs for PSTs who are aware of or sensitive to language as a tool for learning.
Investigación y pedagogía desde y para una visión administrativa
Authors: Bolaños Garita Rolando
Published: November 2021

El presente ensayo surge conforme el interés de determinar por qué la investigación y la pedagogía juegan un papel fundamental para que una disciplina como la administración sea catalogada como científica, tomando como referente lo realizado desde la Escuela de Ciencias de la Administración (ECA) de la Universidad Estatal a Distancia (UNED), para fortificar la capacidad investigativa de sus educandos. De esta manera, se llevó a cabo un abordaje cualitativo mediante el análisis documental adaptado a las propias ciencias administrativas, vislumbrándose elementos variopintos que le confieren a dicha disciplina el halo de cientificidad, al tiempo que se explotan los recursos tecnológicos actuales para desarrollar competencias investigativas en aquellos mismos estudiantes.
relación entre liderazgo adaptativo y calidad de vida en una organización del sector eléctrico colombiano bajo el contexto pandemia covid-19
Authors: Santiago Torner Carlos
Published: November 2021

El objetivo de esta investigación ha sido examinar la relación entre el liderazgo adaptativo existente en una organización del sector eléctrico colombiano y los cambios en la calidad de vida de sus empleados bajo el contexto pandemia covid-19, a través de un diseño no experimental, transversal y correlacional, con un enfoque cuantitativo. Como resultados, se establece una relación débil con el indicador relaciones familiares y sociales, junto con correspondencias de moderadas a fuertes con los seis (6) indicadores restantes: bienestar emocional; condiciones económicas y bienestar material; percepción y protección de la salud; trabajo y otras formas de actividad productivas; percepción de seguridad y sostenibilidad organizacionales e integración a la comunidad laboral.
Propuesta para el financiamiento del departamento de incendios forestales del Cuerpo de Bomberos Voluntarios del municipio de Tuluá, Valle del Cauca, según lo planteado por Berger y Udell
Authors: Azcarate Buitrago Jorge , León Velez Jeison
Published: November 2021

Este trabajo busca proponer estrategias para el financiamiento del departamento de incendios forestales del Cuerpo de Bomberos Voluntarios del municipio de Tuluá, Valle del Cauca, el cual a partir de un diagnóstico que, tras ser realizado, facilita diseñar estrategias orientadas a facilitar su financiamiento. Para esto se enumeran los elementos de tipo teórico y de práctica contable que puedan hacer viable tal crecimiento financiero institucional. Para ello, se perfilan las características de tipo institucional y organizacional de la entidad abordada. A nivel de soluciones, se propone en el trabajo buscar la cofinanciación a través del Fondo Nacional de Bomberos, por medio de presentación de proyectos, o por medio de las fuentes de financiación definidas en el modelo del ciclo de crecimiento financiero planteado por Berger y Udell (1998).
Prácticas de costeo en la determinación del PVP de las Pymes manufactureras de la ciudad de Cuenca, Ecuador
Authors: Estrella Guaman Jessica , Montero Piedra Diego , Vázquez Loaiza Juan
Published: November 2021

La investigación examinó los efectos de prácticas de costeo en pequeñas y medianas empresas manufactureras de Cuenca. Se realizó un estudio cualitativo-cuantitativo con base en el análisis de las prácticas de costeo utilizadas, a través de una encuesta de tipo probabilístico con una confiabilidad del 95% sobre una población de 50 empresas. Aplicándose una simulación de los sistemas de costo estándar, costeo objetivo y contabilidad de Trúput en las cinco pequeñas y medianas empresas que autorizaron la investigación, demostrando la diferencia en los valores obtenidos entre costos y utilidades. Los resultados identificaron como causas de los fracasos el desconocer los sistemas de costos, aplicar una metodología de costeo débil y no llevar sistemas de contabilidad. Se destaca que el empleo del costeo objetivo alcanzó mayor impacto en tres (3) de las empresas, obteniéndose un menor costo de producción y mayores utilidades, seguido por la contabilidad de Trúput que fue efectiva en las dos (2) empresas restantes.
A REVIEW OF DISRUPTION MANAGEMENT IN VEHICLE ROUTING PROBLEM (VRP), TRANSPORT DESIGN AND SCHEDULING
Authors:   Catholic University College of Ghana, Odum James Kwabena , Owusu-Addo Rev Fr. Dr. Augustine , Kyere-Sacrifice Nana , Kwarteng Addai-Amoah Anthony ,   Catholic University College of Ghana,   Catholic University College of Ghana
Published: November 2021

In the case of an unexpected occurrence, disruption management is a method of rescheduling activities and it has been used in a variety of fields, including organized carrier scheduling and project management. The purpose of this review is to examine Ant Colony Optimization (ACO), the problems of Heuristics for Delivery Waste Collection (VRP), ARC Routing, Node Routing, and Container/skip. Other issues and problems examined in the paper were Non-Skip, Algorithms for the VRP, Improvement Algorithms, Simulated Annealing, and ACO for Capacitated Vehicle Routing, Clustering Analysis, and Probabilistic-D Cluster Analysis. It covers the fundamental characteristics of disruption management as well as the related goals and kinds of disruption that may occur in this setting. The various formulations and solution techniques are discussed in facets. A collection of relevant articles has been summarized and categorized according to the kind of disruption problem being addressed, the relevant goals, and the solution method used to resolve the problem. Vehicles must be emptied at a trash disposal facility before they may be used to collect garbage from further clients. The growing amount of solid waste generated as a result of p
COMMUNAL FIXED POINT IN FUZZY 2- METRIC SPACES
Authors:   Department of Computer Science, Catholic University College of Ghana, A Atianashie Miracle
Published: November 2021

The objective of this paper is to emphasize the Common Fixed Point in Fuzzy 2- Metric Spaces and prove a common fixed point theorem of compatible mappings of type (R) in fuzzy 2-metric space. We consider four mappings of which one is continuous. The results generalize many results in the literature. Some illustrative examples are furnished which demonstrate the validity of the hypotheses and the degree of utility of our results.
EVALUATION OF THE IMPLEMENTATION OF ELECTRONIC HEALTH RECORD SYSTEM: CASE STUDY OF THE PRESBYTERIAN HOSPITAL AT DORMAA AHENKRO OF BONO REGION, GHANA
Authors:   Department of Computer science, Kwame Nkrumah University of Science and Technology, Frimpong Rita
Published: November 2021

The main objective of this study is to evaluate the implementation of electronic health records at Presbyterian Hospital in Dormaa Ahenkro, Bono Region, Ghana. A total sample size of 50 staff and management of the hospital were sampled using the purposive sampling technique. Qualitative data was collected using questionnaires and observational checklists enlisting the workings of the facilities or technology, while quantitative data was captured using Key Informant Interview (KII) guides with key management staff of the hospital. Data analysis was done descriptively using the Statistical Package for Social Sciences software (SPSS version 21.0). The study revealed that factors such as expectancy of performance, anticipation or effort, facilitating conditions, and social influence highly influence the management of the hospital to adopt the technology. The study revealed that frequent power outages are the main challenge they are confronted with. The study recommended that management implement safeguards ensure the system stands against loss, destruction, interfering, and unlawful use of the EHR system. System safeguards must be in place. Management through the IT unit should consider procurement of an efficient backup system and regular change of passwords to maintain the security of the system.
Grounded Utopia
Authors: Davis Laurence
Published: November 2021

The concept of utopia is from the moment of its inception umbilically tied to modern conceptions of progress that have legitimized settler colonialism, the genocide of Indigenous peoples, the violent subordination of women and racial and sexual “others,” ecocide, and a “grow or die” form of civilization that is now threatening the very existence of all life on the planet. Drawing on the critical socialist insights of Gustav Landauer, Ernst Bloch, and Walter Benjamin, and the “non-Euclidean” utopianism of Ursula K. Le Guin, this article challenges the common association between utopia and culturally dominant ideas of progress and outlines a temporally and spatially grounded alternative approach to the study of utopias suitable to a post-anthropocentric world. The aims of the analysis are at once scholarly and practical: scholarly, inasmuch as it develops conceptual tools conducive to fresh interpretations of utopian texts and practices; and practical, insofar as it vitalizes utopian thought and action by illuminating hitherto obscure aspects of utopianism’s transformative potential.
The Closed West: Rajneeshpuram and the Failure of Utopia in Antelope, Oregon
Authors: Robertson Jesse
Published: November 2021

Settler colonialism lay at the heart of the dispute between Oregonians and the followers of Bhagwan Shree Rajneesh, who built a utopian community called Rajneeshpuram in central Oregon between 1981 and 1985. Rajneeshpuram’s inhabitants believed their environmentalist ambitions would align them with settler-spirited and eco-minded Oregonians. However, Oregon’s land use laws were rooted in the dispossession of Native land, a foundational theft that was reinstantiated in present-day hierarchies of land use and ownership. Many Oregonians simultaneously saw the residents of Rajneeshpuram as invaders and invoked frontier narratives in their defense, blending them with prevalent political and cultural concerns of contamination. Rajneesh and his followers’ disregard for zoning laws and inflammatory tactics brought about their community’s undoing. Rajneeshpuram thus challenged an arrangement that was the historical product of settler colonialism while replicating it. The conflict was mired in the idealistic—and incompatible—self-interest of opposing settler groups.