bluuebunny/crossref_metadata_2025 huggingface dataset:
Sex differences in COVID-19: the role of androgens in disease severity and progression
Authors: Mohamed Mohamed S. , Moulin Thiago C. , Schiöth Helgi B.
Published: November 2020

Purpose

Throughout the SARS-CoV2 pandemic, multiple reports show higher percentages of hospitalization, morbidity, and mortality among men than women, indicating that men are more affected by COVID-19. The pathophysiology of this difference is yet not established, but recent studies suggest that sex hormones may influence the viral infectivity process. Here, we review the current evidence of androgen sensitivity as a decisive factor for COVID-19 disease severity.

Methods

Relevant literature investigating the role of androgens in COVID-19 was assessed. Further, we describe several drugs suggested as beneficial for COVID-19 treatment related to androgen pathways. Lastly, we looked at androgen sensitivity as a predictor for COVID-19 progression and ongoing clinical trials on androgen suppression therapies as a line of treatment.

Results

SARS-COV2 virus spike proteins utilize Transmembrane protease serine 2 (TMPRSS2) for host entry. Androgen receptors are transcription promoters for TMPRSS2 and can, therefore, facilitate SARS-COV2 entry. Variants in the androgen receptor gene correlate with androgen sensitivity and are implicated in diseases like androgenetic alopecia and prostate cancer, conditions that have been associated with worse COVID-19 outcomes and hospitalization.

Conclusion

Androgen’s TMPRSS2-mediated actions might explain both the low fatalities observed in prepubertal children and the differences between sexes regarding SARS-COV2 infection. Androgen sensitivity may be a critical factor in determining COVID-19 disease severity, and sensitivity tests can, therefore, help in predicting patient outcomes.
Application of Constrained Optimization Techniques in Optimal Shape Design of a Freezer to Dosing Line Splitter for Ice Cream Production
Authors: Sarghini Fabrizio , De Vivo Angela
Published: November 2020

Design of multiple branches splitting of equal mass flow rate in complex rheological flows like ice cream near melting point temperature can be a challenging task. Pulsations in flow rate due to air pumping process and small fluctuations in temperature affecting flow rheology can determine a consistent difference in internal pipe velocity distribution, resulting in a significant difference in the distribution of ice cream dosage. Computational sciences and engineering techniques have allowed a major change in the way products and equipment can be engineered, as a computational model simulating physical processes can be more easily obtained, rather than making prototypes and performing multiple experiments. Among such techniques, optimal shape design (OSD) represents an interesting approach. In OSD, the essential element with respect to classical numerical simulations in fixed geometrical configurations relays on the introduction a certain amount of geometrical degrees of freedom as a part of the unknowns. This implies that the geometry is not completely defined, but part of it is allowed to move dynamically in order to minimize or maximize an objective function. From a mathematical point of view, OSD is a branch of differentiable optimization and more precisely the application of optimal control for distributed systems. OSD is still today numerically difficult to implement, because it relies on a computer intensive activity and moreover because the concept of “optimal” is a compromise between shapes that are good with respect to several criteria. In this work, the applications of a multivariate constrained optimization algorithm is proposed in the case of a mechanical ice cream 1 to 5 splitting system, required to distribute in an evenly way from one freezer into five dosing valves. Results allowed to design a retro-fitting system on an existing production plant reducing the dosing error down to 3% on the average.
Robot-assisted adrenalectomy: state of the art
Authors: Materazzi Gabriele , Rossi Leonardo
Published: November 2020

Currently, laparoscopic adrenalectomy is worldwide considered the gold standard technique. Both transperitoneal and retroperitoneal approaches have proved their efficacy with excellent outcomes. Since the introduction of da Vinci System (Intuitive Surgical, Sunnyvale, CA), robotic surgery has made many steps forward gaining progressively more diffusion in the field of general and endocrine surgery. The robotic technique offers advantages to overcome some laparoscopic shortcomings (rigid instruments, loss of 3D vision, unstable camera). Indeed, the robotic system is provided of stereoscopic 3D-magnified vision, additional degree of freedom, tremor-filtering technology and a stable camera. Recently, several case series have demonstrated the feasibility and the safety of robot-assisted adrenalectomy in high-volume centers with outcomes comparable to laparoscopic adrenalectomy. Notwithstanding, the technical advantages of the robotic system have not yet demonstrated significant improvements in terms of outcomes to undermine laparoscopic adrenalectomy. Moreover, robotic adrenalectomy harbor inherits drawbacks, such as longer operative time and elevated costs, that limit its use. In particular, the high cost associated with the use of the robotic system is primarily related to the purchase and the maintenance of the unit, the high instruments cost and the longer operative time. Notably, these aspects make robotic adrenalectomy up to 2.3 times more costly than laparoscopic adrenalectomy. This literature review summarizes the current available studies and provides an overview about the robotic scenario including applicability, technical details and surgical outcomes.
Skin Immunology and Rejection in VCA and Organ Transplantation
Authors: Leonard D. A. , Amin K. R. , Giele H. , Fildes J. E. , Wong Jason K. F.
Published: November 2020

Purpose of Review

Skin provides a window into the health of an individual. Using transplanted skin as a monitor can provide a powerful tool for surveillance of rejection in a transplant. The purpose of this review is to provide relevant background to the role of skin in vascularized transplantation medicine.

Recent Findings

Discrete populations of T memory cells provide distributed immune protection in skin, and cycle between skin, lymph nodes, and blood. Skin-resident TREGcells proliferate in response to inflammation and contribute to long-term VCA survival in small animal models. Early clinical studies show sentinel flap rejection to correlate well with facial VCA skin rejection, and abdominal wall rejection demonstrates concordance with visceral rejection, but further studies are required.

This review focuses on the immunology of skin, skin rejection in vascularized composite allografts, and the recent advances in monitoring the health of transplanted tissues using distant “sentinel” flaps.
Comparative evaluation of pattern mining techniques: an empirical study
Authors: Borah Anindita , Nath Bhabesh
Published: November 2020

Pattern mining has emerged as a compelling field of data mining over the years. Literature has bestowed ample endeavors in this field of research ranging from frequent pattern mining to rare pattern mining. A precise and impartial analysis of the existing pattern mining techniques has therefore become essential to widen the scope of data analysis using the notion of pattern mining. This paper is therefore an attempt to provide a comparative scrutiny of the fundamental algorithms in the field of pattern mining through performance analysis based on several decisive parameters. The paper provides a structural classification of the widely referenced techniques in four pattern mining categories: frequent, maximal frequent, closed frequent and rare. It provides an analytical comparison of these techniques based on computational time and memory consumption using benchmark real and synthetic data sets. The results illustrate that tree based approaches perform exceptionally well over level wise approaches in case of dense data sets for all the categories. However, for sparse data sets, level wise approaches performed better than the former ones. This study has been carried out with an aim to analyze the pros and cons of the well known pattern mining techniques under different categories. Through this empirical study, an endeavor has been made to enable the researchers identify some fruitful and promising research directions in one of the most remarkable area of research, pattern mining.
On the cohomology of the space of seven points in general linear position
Authors: Bergvall Olof
Published: November 2020

We determine the cohomology groups of the space of seven points in general linear position in the projective plane as representations of the symmetric group on seven elements by making equivariant point counts over finite fields. We also comment on the case of eight points.
The epidemiology of lymphoma in Jordan
Authors: Aladily Tariq N. , Khreisat Wiam , Ashukhaibi Omar , Alkhatib Sohaib M. , Annab Hassan , Tarawneh Musleh S. , Salman Thaher S. , Farsakh Hussam Abu , Mahgoub Randa , Bustami Nadwa , Mansour Ahmad T. , AlRyalat Saif Aldeen , Abbadi Abdalla S. , Al-Fararjeh Feras , Sughayer Maher , Jaber Omar
Published: November 2020

Objective/Background:

Lymphoma is a common human cancer that shows a variable geographic incidence worldwide. It is the fourth most common cancer in Jordan. Systemic reports of descriptive epidemiology on lymphoma from the Middle East are limited.

Methods:

A nationwide multi-institutional retrospective study was conducted covering all major hospitals and laboratories that provide diagnostic services. We collected data on all cases diagnosed with lymphoma between 2014 and 2019. The included variables were patients’ age, gender, anatomic site, and the histologic type according to the World Health Organization classification system.

Results:

A total of 4189 cases were diagnosed with lymphoma. There was a statistically significant gender difference (p < .05), as 57.5% of patients were males. The peak incidence occurred at age 25-55 years. There were 1,652 (39%) cases of Hodgkin lymphoma (HL) and 2,537 (61%) of non-Hodgkin lymphoma (NHL), where nodular sclerosis (67%) and diffuse large B-cell lymphoma (53%) were the most common subtypes, respectively. The average age-adjusted incidence rates per 100,000 population were 8.01 for all lymphomas, 4.33 for NHL, and 3.16 for HL and all remained stable over the 6 years.

Conclusion:

HL is the most common lymphoma in Jordan, with a percentage higher than most of reported studies in Asian and Western countries. It also shows a unimodal distribution of age-specific incidence rates, with a single peak in young adults. The incidence rate of HL is higher than Eastern countries but comparable to the West. In contrast, NHL demonstrates a lower incidence rate than Western countries but a similar distribution of subtypes, as mature T/natural killer-cell lymphomas were rare.
Investigating the Potential of Deaccessioning as a Tool for Public Archaeology Education
Authors: Domeischel Jenna , Waggle Tawnya
Published: November 2020

In the United States, deaccessioning is a poorly understood collections management tool. Archaeologists often view deaccessioning with what Robert Sonderman called “primal fear,” and this fear has caused them to overlook the opportunities that deaccessioned artifacts and collections may provide in the area of public archaeology education. Although deaccessioning without checks and balances can be problematic, when done properly and ethically, it offers previously untapped resources to the creation of educational programming, such as teaching trunk programs. This article discusses the process of deaccessioning and suggests that deaccessioned artifacts may be useful as content for teaching trunk programs. We discuss a case study from our own institution, where we implemented a trunk program in 2016 that was largely stocked with material from a deaccession we had performed the previous year. We also offer suggestions for anyone wishing to implement a similar program.
A stratigraphy-based method for reconstructing ice core orientation
Authors: Westhoff Julien , Stoll Nicolas , Franke Steven , Weikusat Ilka , Bons Paul , Kerch Johanna , Jansen Daniela , Kipfstuhl Sepp , Dahl-Jensen Dorthe
Published: November 2020

Ever since the first deep ice cores were drilled, it has been a challenge to determine their original, in-situ orientation. In general, the orientation of an ice core is lost as the drill is free to rotate during transport to the surface. For shallow ice cores, it is usually possible to match the adjacent core breaks, which preserves the orientation of the ice column. However, this method fails for deep ice cores, such as the EastGRIP ice core in Northeast Greenland. We provide a method to reconstruct ice core orientation using visual stratigraphy and borehole geometry. As the EastGRIP ice core is drilled through the Northeast Greenland Ice Stream, we use information about the directional structures to perform a full geographical re-orientation. We compared the core orientation with logging data from core break matching and the pattern of the stereographic projections of the crystals’ c-axis orientations. Both comparisons agree very well with the proposed orientation method. The method works well for 441 out of 451 samples from a depth of 1375–2120 m in the EastGRIP ice core. It can also be applied to other ice cores, providing a better foundation for interpreting physical properties and understanding the flow of ice.
Bilateral defence and security cooperation despite disintegration: Does the Brexit process divide the United Kingdom and Germany on Russia?
Authors: Driedger Jonas J.
Published: November 2020

With wavering US support and Brexit unfolding, cooperation between Germany, the EU's economic powerhouse, and the United Kingdom, Western Europe's prime military power, becomes crucial for Europe's overall ability to deal with a resurgent Russia. Does institutional and normative disintegration between states, such as the Brexit process, weaken bilateral security cooperation? This article argues that such cooperation persists if both states continue to jointly perceive a third actor as threatening while regarding each other as useful and reliable when it comes to ameliorating this shared threat. The argument is tested on a case of intrinsic theoretical, historical, and political importance: British-German cooperation towards Russia before and after the 2016 Brexit referendum. The article finds, against a wide pessimist consensus to the contrary, that cooperation strengthened during the Brexit process. As the Ukraine crisis had caused converging threat perceptions since 2014, Brexit incentivised both sides to signal ongoing reliability to each other and, consequently, to view each other as more capable allies. The article combines qualitative comparisons and congruence analysis, drawing data from British, German and Russian primary sources in their respective original languages, including foreign and security policy documents as well as interviews with stakeholders involved in policy formation.
Lower placental 25-hydroxyvitamin D3 (25(OH)D3) and higher placental CYP27B1 and 25(OH)D3 ratio in preterm birth
Authors: Irwinda Rima , Andardi Biancha
Published: November 2020

Neonatal mortality rates in Indonesia are still at an alarming rate, with preterm birth as one of the causes. Nutritional deficiencies such as low level of vitamin D is suspected to be the risk factors of preterm birth but still a little knowledge about it. Vitamin D metabolism includes 25-hydroxyvitamin D3 (25(OH)D3) and 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), as the inactive and active form, with the help of 1α-hydroxylase (CYP27B1) enzyme. Our study aims to determine the differences of 25(OH)D3, 1,25(OH)2D3 and CYP27B1 enzyme in term and preterm birth. A cross-sectional study was performed in Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia, in January–June 2017. The blood sample was taken soon after delivery, to examine maternal 25(OH)D3 and 1,25(OH)2D3 in serum and tissue placenta, as well as placental CYP27B1 enzyme. Statistical analysis using SPPS version 20 was used to find significances. There were a total of sixty subjects in this study, with term-preterm birth group ratio 1:1. We found that placental 25(OH)D3 was significantly low (P = 0⋅001), and CYP27B1/25(OH)D3 ratio was high in preterm birth. Also, there were significant negative correlations found in CYP27B1 level and both placental 25(OH)D3 (r 0⋅481, P < 0⋅001) and 1,25(OH)2D3 (r −0⋅365, P = 0⋅004) levels. Our study concludes that preterm birth showed lower placental 25(OH)D3 status, and higher CYP27B1/25(OH)D3 ratio compared to term pregnancy.
A General Approach to Measuring Electoral Competitiveness for Parties and Governments
Authors: Cronert Axel , Nyman Pär
Published: November 2020

We develop a general approach to measuring electoral competitiveness for parties and governments, which is distinct from existing approaches in two ways. First, it allows us to estimate the actual probability of re-electing the incumbent into office, which lies closer to the theoretical concept of interest than most widely used proxies. Second, it incorporates both pre-electoral competitiveness—that is, the uncertainty about the outcome of the upcoming election—and post-electoral competitiveness—that is, the uncertainty concerning who will form the government given a certain election result. The approach can be applied to, and compared across, a multitude of institutional settings and is particularly advantageous in analyses of multiparty democracies. To demonstrate its full potential, we first apply the approach on 1,700 local government elections in Sweden. Three advantages over existing approaches are documented: Our election probability measure shows substantial variation over the election cycle, it can be accurately measured for a single party as well as a government, and it is more capable of predicting re-election into office than any previous measure of electoral competitiveness. A second application on 400 national elections in 34 democracies shows that the approach also works well in a more challenging cross-national setting.
A ROMAN TEMPLE FROM SOUTHERN BRITAIN: RELIGIOUS PRACTICE IN LANDSCAPE CONTEXTS
Authors: Henry Richard , Roberts David , Roskams Steve
Published: November 2020

Traditionally, Roman temples and shrines in Britain have been contextualised in relation to wider ‘Roman’ religious practices. Until recently, considerations of architectural form and named deities have dominated discussions. The wider turn in archaeological discourse recognising ritual in everyday contexts has highlighted the importance of lived experience and landscape practice in shaping belief. Here we reflect on the implications of such ideas when approaching ritual practice at Roman temples, using a recently excavated example from Wiltshire, southern Britain, as a case study. The exceptional artefactual assemblages from the site demonstrate the importance of local and regional landscape practices and belief in shaping ritual practice in a sacred space. In addition, geophysical survey and analysis of Portable Antiquities Scheme (PAS) finds suggests that those occupying the landscape had long-term access to wealth. Deposition in the temple itself indicates the continuing importance attached to prehistoric objects in the Roman period, but also to the adoption of new votive practices of miniaturisation, mutilation and sacrifice. These rituals, although part of wider grammars of religious behaviour, had their roots in specific local contexts. Our detailed analyses provide a picture of a temple dedicated to a previously unknown local god, Bregneus, framed against that of an active community involved in farming, iron processing, quarrying, hunting and woodland management.
Performance, radiation capture and use by maize–mungbean–common bean sequential intercropping under different leaf removal and row orientation schemes
Authors: Worku Walelign
Published: November 2020

Food security under smallholder farming can be improved through innovative intensification of cropping systems. Maize (Zea mays L.) – mungbean (Vigna radiata (L.) Wilczek) – common bean (Phaseolus vulgaris L.) sequential intercropping was studied to evaluate the patterns of radiation capture and radiation use efficiency and to determine the effects of leaf removal and row orientation on performance and intercropping efficiency. Sequential intercropping captured 1039 MJ m−2 photosynthetically active radiation (PAR) accounting for 70% of incident seasonal PAR. The corresponding sole stands for maize captured 41%, mungbean 29%, common bean 34% and mungbean–common bean 63%. Intercropped components had interception ratios of 0.98, 0.31 and 0.61 for maize, mungbean and common bean, respectively. Associated maize used intercepted light with similar efficiency, mungbean with greater efficiency and common bean with lesser efficiency compared to sole crops. Maize leaf removal and row orientation had no significant effect on performance and partial land equivalent ratio (LER) of maize. Leaf removal under East–West (EW) orientation increased grain yield by 96%, total biomass by 63%, partial LER by 92%, in common bean and total LER by 7%. Leaf removal also improved grain yield, biomass yield, partial LER, in common bean and total LER during the wetter year of 2013. Similarly, EW orientation was advantageous in 2013 raising total LER by 8%. Maize leaf removal and EW row orientation had synergistic effects on intercropping efficiency and economic benefit and both have exerted positive influence under favourable weather. Total LER values of 1.47 in 2013 and 1.29 in 2015 had revealed greater biological efficiency for intercropping during both years though it was more profitable in 2013. Thus, the cropping system can be adopted under timely onset of the rainy season using EW row orientation while leaf removal can also be practiced depending on weather conditions and convenience.
SALT AND SOVEREIGNTY IN COLONIAL BURMA
Authors: LALLY JAGJEET
Published: November 2020

Across monsoon Asia, salt is of such vital necessity that controlling its production or supply has historically been connected to the establishment and expression of political authority. On the one hand, rulers maintained the allegiance of their subjects by ensuring their access to salt of suitable price and sufficient quantity. On the other hand, denying rebels their salt was a strategy of conquest and pacification, while the necessity of salt meant it could reliably be taxed to raise state finances. This article first sets out this connection of salt and sovereignty, then examining it in the context of colonial Burma, a province of British India from its annexation until its ‘divorce’ in 1935 (effected in 1937), and thus subject to the Government of India's salt monopoly. Focusing on salt brings into view two aspects of the state (while also permitting analysis of ‘Upper Burma’, which remains rather marginal in the scholarly literature). First, the everyday state and quotidian practices constitutive of its sovereignty, which was negotiated and contested where indigenes were able to exploit the chinks in the state's administrative capacity and its knowledge deficits. Second, in turn, the lumpy topography of state power. The state not only failed to restrict salt production to the extent it desired (with the intention that indigenes would rely on imported salt, whose supply was easier to control and thus tax), but conceded to a highly complex fiscal administration, the variegations in which reflected the uneven distribution in state power – thicker in the delta and thinnest in the uplands.
Changes in phytoplankton composition of the Golden Horn Estuary (Sea of Marmara) following remediation
Authors: Tas Seyfettin
Published: November 2020

Changes in phytoplankton composition of the Golden Horn Estuary were investigated following remediation, through seawater transfer from the Strait of Istanbul to the estuary. Average values of Secchi depth, salinity and dissolved oxygen increased during this study when compared with a previous study. The average number of species (S) and species diversity (H′) increased and they correlated positively with Secchi depth, salinity and dissolved oxygen. There was a similar phytoplankton group composition between this and a previous study, however, the species composition differed. A total of 127 taxa consisting of diatoms (66 taxa), dinoflagellates (49 taxa) and others (12 taxa) were identified. Abundance of dinoflagellates and phytoflagellates and their relative contribution to the total phytoplankton abundance increased during this study, however, the abundance of diatoms and their relative contribution decreased notably, as compared with the previous study. There was a significant positive correlation between salinity and dinoflagellates and phytoflagellates (P< 0.01), and also between Secchi depth and dinoflagellates (P< 0.01) in the upper estuary. Additionally, salinity and Secchi depth correlated positively with species diversity (H′) and number of species (S) (P< 0.01). The increase in water transparency probably contributed to the increase in abundance of dinoflagellates and phytoflagellates. The results revealed that water transparency was one of the most important factors affecting phytoplankton composition in the study area. Changes in some environmental conditions following seawater transfer appear to have changed phytoplankton composition. As a result, phytoplankton species were confirmed as a very good indicator of changed environmental conditions.
Measuring bilingualism: The quest for a “bilingualism quotient”
Authors: Marian Viorica , Hayakawa Sayuri
Published: November 2020

The study of bilingualism has a history that extends from deciphering ancient multilingual texts to mapping the structure of the multilingual brain. The language experiences of individual bilinguals are equally diverse and characterized by unique contexts of acquisition and use that can shape not only sociocultural identity but also cognitive and neural function. Perhaps unsurprisingly, this variability in scholarly perspectives and language experiences has given rise to a range of methods for defining bilingualism. The goal of this article is to initiate a conversation about the utility of a more unified approach to how we think about, study, and measure bilingualism. Using concrete case studies, we illustrate the value of enhancing communication and streamlining terminology across researchers with different methodologies within questions, different questions within domains, and different domains within scientific inquiry. We specifically consider the utility and feasibility of a bilingualism quotient (BQ) construct, discuss the idea of a BQ relative to the well-established intelligence quotient, and include recommendations for next steps. We conclude that though the variability in language backgrounds and approaches to defining bilingualism presents significant challenges, concerted efforts to systematize and synthesize research across the field may enable the construction of a valid and generalizable index of multilingual experience.
Psychische Störungen bei MigrantInnen
Authors: Schouler-Ocak Meryam , Graef-Calliess Iris T. , Bajbouj Malek , Plener Paul L.
Published: November 2020

Zusammenfassung. Kinder und Jugendliche mit Migrations- und Fluchthintergrund unterliegen einerseits diversen gesundheitlichen, psychosozialen, soziokulturellen sowie ökonomischen Belastungen, die Prävalenz, Manifestation, Verlauf und Behandlung sowie die Prognose von psychiatrischen Erkrankungen beeinflussen können, und sind andererseits in der Inanspruchnahme und Behandlung durch zahlreiche Zugangsbarrieren im Vergleich zu Einheimischen deutlich benachteiligt. Die Transitionslücke verschärft die Situation. Zur Verbesserung der Versorgungssituation werden in Analogie zur Situation bei jungen Erwachsenen auch für Kinder und Jugendliche mit Migrations- und Fluchthintergrund Forderungen aufgestellt. So werden im stationären Rahmen bei ihrer unzureichenden Versorgung die Etablierung sogenannter Adoleszentenstationen unter kinder- und jugend- und erwachsenenpsychiatrisch-psychotherapeutischer Leitung und mit entsprechender pflegerischer und therapeutischer Personalausstattung sowie in Anlehnung an ein Entlassmanagement ein sog. „Transitionsmanagement“ im klinischen Alltag sowie der Erwerb von interkultureller Kompetenz empfohlen.
The Two-Year On-Ramp
Authors: Duncombe Jenessa
Published: November 2020

This community college in Texas has figured out how to guide its students into geoscience careers.
Millennial‐Scale Changes in Terrestrial and Marine Nitrous Oxide Emissions at the Onset and Termination of Marine Isotope Stage 4
Authors: Menking J. A. , Brook E. J. , Schilt A. , Shackleton S. , Dyonisius M. , Severinghaus J. P. , Petrenko V. V.
Published: November 2020

Ice core measurements of the concentration and stable isotopic composition of atmospheric nitrous oxide (N2O) 74,000–59,000 years ago constrain marine and terrestrial emissions. The data include two major Dansgaard‐Oeschger (D‐O) events and the N2O decrease during global cooling at the Marine Isotope Stage (MIS) 5a‐4 transition. The N2O increase associated with D‐O 19 (~73–71.5 ka) was driven by equal contributions from marine and terrestrial emissions. The N2O decrease during the transition into MIS 4 (~71.5–67.5 ka) was caused by gradual reductions of similar magnitude in both marine and terrestrial sources. A 50 ppb increase in N2O concentration at the end of MIS 4 was caused by gradual increases in marine and terrestrial emissions between ~64 and 61 ka, followed by an abrupt increase in marine emissions at the onset of D‐O 16/17 (59.5 ka). This suggests that the importance of marine versus terrestrial emissions in controlling millennial‐scale N2O fluctuations varied in time.
Contrasting Recent and Future ITCZ Changes From Distinct Tropical Warming Patterns
Authors: Zhou Wenyu , Leung L. Ruby , Lu Jian , Yang Da , Song Fengfei
Published: November 2020

This study synthesizes the observed trends and projected changes in the Intertropical Convergence Zones (ITCZs). Under future warming, the seasonal ITCZs are projected to shift equatorward, widen, and weaken. The equatorward‐shifted seasonal ITCZs cause a squeeze of the annual‐mean zonal‐mean tropical ascent. Over 1979–2014, however, the seasonal ITCZs have shifted poleward in South Pacific and generally narrowed and strengthened. The observed annual‐mean zonal‐mean changes are largely opposite to the future squeeze. Such contrasting ITCZ changes are attributed to the distinct tropical warming patterns. Specifically, the equatorial Pacific has cooled following a phase change in the Pacific Decadal Oscillation (PDO) but will warm more than the tropics in future. The ITCZ response to tropical warming pattern is consistent with thermodynamic/energetic theories and demonstrated through SST‐forced experiments. In the coming decades, a positive PDO can act jointly with anthropogenically forced equatorial warming, leading to substantial ITCZ changes that are distinct from recent trends.
Japanese insurers’ attitudes toward adverse selection and genetic discrimination: a questionnaire survey and interviews with employees about using genetic test results
Authors: Iida Hiroshi , Muto Kaori
Published: November 2020

Since the 1990s, insurance has been the primary field focused on the social disadvantages of using genetic test results because of the concerns related to adverse selection. Although life insurance is popular in Japan, Japan does not currently have any regulations on the use of genetic information and insurers have largely kept silent for decades. To reveal insurers’ attitudes on the topic, we conducted an anonymous questionnaire survey with 100 insurance company employees and recruited nine interviewees from the survey respondents. We found that genetic discrimination is not generally considered as a topic of human rights. We also found that insurers have uncertain fears and concerns about adverse selection in terms of actuarial fairness but not regarding profits. When it comes to preparing guidelines on the use of genetic information by Japanese insurers, we believe that public dialog and consultation are necessary to gain understanding of the people.
Mood stabilizers and/or antipsychotics for bipolar disorder in the maintenance phase: a systematic review and network meta-analysis of randomized controlled trials
Authors: Kishi Taro , Ikuta Toshikazu , Matsuda Yuki , Sakuma Kenji , Okuya Makoto , Mishima Kazuo , Iwata Nakao
Published: November 2020

We searched Embase, PubMed, and CENTRAL from inception until 22 May 2020 to investigate which antipsychotics and/or mood stabilizers are better for patients with bipolar disorder in the maintenance phase. We performed two categorical network meta-analyses. The first included monotherapy studies and studies in which the two drugs used were specified (i.e., aripiprazole, aripiprazole once monthly, aripiprazole+lamotrigine, aripiprazole+valproate, asenapine, carbamazepine, lamotrigine, lamotrigine+valproate, lithium, lithium+oxcarbazepine, lithium+valproate, olanzapine, paliperidone, quetiapine, risperidone long-acting injection, valproate, and placebo). The second included studies on second-generation antipsychotic combination therapies (SGAs) (i.e., aripiprazole, lurasidone, olanzapine, quetiapine, and ziprasidone) with lithium or valproate (LIT/VAL) compared with placebo with LIT/VAL. Outcomes were recurrence/relapse rate of any mood episode (RR-any, primary), depressive episode (RR-dep) and manic/hypomanic/mixed episode (RR-mania), discontinuation, mortality, and individual adverse events. Risk ratios and 95% credible interval were calculated. Forty-one randomized controlled trials were identified (n = 9821; mean study duration, 70.5 ± 36.6 weeks; percent female, 54.1%; mean age, 40.7 years). All active treatments other than carbamazepine, lamotrigine+valproate (no data) and paliperidone outperformed the placebo for RR-any. Aripiprazole+valproate, lamotrigine, lamotrigine+valproate, lithium, olanzapine, and quetiapine outperformed placebo for RR-dep. All active treatments, other than aripiprazole+valproate, carbamazepine, lamotrigine, and lamotrigine+valproate, outperformed placebo for RR-mania. Asenapine, lithium, olanzapine, quetiapine, and valproate outperformed placebo for all-cause discontinuation. All SGAs+LIT/VALs other than olanzapine+LIT/VAL outperformed placebo+LIT/VAL for RR-any. Lurasidone+LIT/VAL and quetiapine+LIT/VAL outperformed placebo+LIT/VAL for RR-dep. Aripiprazole+LIT/VAL and quetiapine+LIT/VAL outperformed placebo+LIT/VAL for RR-mania. Lurasidone+LIT/VAL and quetiapine+LIT/VAL outperformed placebo+LIT/VAL for all-cause discontinuation. Treatment efficacy, tolerability, and safety profiles differed among treatments.
EMC6 regulates acinar apoptosis via APAF1 in acute and chronic pancreatitis
Authors: Tan Jie-hui , Cao Rong-chang , Zhou Lei , Zhou Zhi-tao , Chen Huo-ji , Xu Jia , Chen Xue-mei , Jin Yang-chen , Lin Jia-yu , Qi Zhao-chang , Zeng Jun-ling , Li Shu-ji , Luo Min , Hu Guo-dong , Jin Jin , Zhang Guo-wei
Published: November 2020

Treatment of acute pancreatitis (AP) and chronic pancreatitis (CP) remains problematic due to a lack of knowledge about disease-specific regulatory targets and mechanisms. The purpose of this study was to screen proteins related to endoplasmic reticulum (ER) stress and apoptosis pathways that may play a role in pancreatitis. Human pancreatic tissues including AP, CP, and healthy volunteers were collected during surgery. Humanized PRSS1 (protease serine 1) transgenic (PRSS1Tg) mice were constructed and treated with caerulein to mimic the development of human AP and CP. Potential regulatory proteins in pancreatitis were identified by proteomic screen using pancreatic tissues of PRSS1Tg AP mice. Adenoviral shRNA-mediated knockdown of identified proteins, followed by functional assays was performed to validate their roles. Functional analyses included transmission electron microscopy for ultrastructural analysis; qRT-PCR, western blotting, co-immunoprecipitation, immunohistochemistry, and immunofluorescence for assessment of gene or protein expression, and TUNEL assays for assessment of acinar cell apoptosis. Humanized PRSS1Tg mice could mimic the development of human pancreatic inflammatory diseases. EMC6 and APAF1 were identified as potential regulatory molecules in AP and CP models by proteomic analysis. Both EMC6 and APAF1 regulated apoptosis and inflammatory injury in pancreatic inflammatory diseases. Moreover, APAF1 was regulated by EMC6, induced apoptosis to injure acinar cells and promoted inflammation. In the progression of pancreatitis, EMC6 was activated and then upregulated APAF1 to induce acinar cell apoptosis and inflammatory injury. These findings suggest that EMC6 may be a new therapeutic target for the treatment of pancreatic inflammatory diseases.
Quercetin promotes in vitro maturation of oocytes from humans and aged mice
Authors: Cao Yongzhi , Zhao Haibin , Wang Zhao , Zhang Changming , Bian Yuehong , Liu Xin , Zhang Chuanxin , Zhang Xin , Zhao Yueran
Published: November 2020

Maternal fertility declines irreversibly with aging, and advanced maternal age is mostly related to impaired oocyte quality. The flavonol compound quercetin is considered to be an anti-aging agent due to its cytoprotective actions as an antioxidant. However, its role and mechanisms on aged oocytes are unclear. In this study, the quercetin promotes in vitro maturation (IVM) and early embryonic development of oocytes from aged mice. It is extended these findings in human oocytes, showing that quercetin promotes the IVM rate by 19.6% and increases the blastocyst formation rate by 15.5% compared to untreated controls. The overall oocyte quality of aged mice is improved by quercetin treatment, assessed as spindle/chromosome morphology and cortical granule distribution. Mitochondria is the primary endogenous source of age-related oxidative stress, and an RNA-seq analysis of quercetin-treated oocytes reveals molecular insights including scavenged mitochondrial-ROS, reduced apoptosis, and improved autophagy. Further, this study demonstrates that quercetin reduces ROS via SIRT3-mediated acetylation of SOD2’s K68 residue. Thus, beyond demonstrating that quercetin confers beneficial mitochondria-related impacts in aged oocytes, this study illustrates a potential strategy to prevent or delay oocyte aging and to improve success rates of assisted human reproductive technologies (ART).
Viral rhodopsins 1 are an unique family of light-gated cation channels
Authors: Zabelskii Dmitrii , Alekseev Alexey , Kovalev Kirill , Rankovic Vladan , Balandin Taras , Soloviov Dmytro , Bratanov Dmitry , Savelyeva Ekaterina , Podolyak Elizaveta , Volkov Dmytro , Vaganova Svetlana , Astashkin Roman , Chizhov Igor , Yutin Natalia , Rulev Maksim , Popov Alexander , Eria-Oliveira Ana-Sofia , Rokitskaya Tatiana , Mager Thomas , Antonenko Yuri , Rosselli Riccardo , Armeev Grigoriy , Shaitan Konstantin , Vivaudou Michel , Büldt Georg , Rogachev Andrey , Rodriguez-Valera Francisco , Kirpichnikov Mikhail , Moser Tobias , Offenhäusser Andreas , Willbold Dieter , Koonin Eugene , Bamberg Ernst , Gordeliy Valentin
Published: November 2020

Phytoplankton is the base of the marine food chain as well as oxygen and carbon cycles and thus plays a global role in climate and ecology. Nucleocytoplasmic Large DNA Viruses that infect phytoplankton organisms and regulate the phytoplankton dynamics encompass genes of rhodopsins of two distinct families. Here, we present a functional and structural characterization of two proteins of viral rhodopsin group 1, OLPVR1 and VirChR1. Functional analysis of VirChR1 shows that it is a highly selective, Na+/K+-conducting channel and, in contrast to known cation channelrhodopsins, it is impermeable to Ca2+ ions. We show that, upon illumination, VirChR1 is able to drive neural firing. The 1.4 Å resolution structure of OLPVR1 reveals remarkable differences from the known channelrhodopsins and a unique ion-conducting pathway. Thus, viral rhodopsins 1 represent a unique, large group of light-gated channels (viral channelrhodopsins, VirChR1s). In nature, VirChR1s likely mediate phototaxis of algae enhancing the host anabolic processes to support virus reproduction, and therefore, might play a major role in global phytoplankton dynamics. Moreover, VirChR1s have unique potential for optogenetics as they lack possibly noxious Ca2+ permeability.
Spin-orbit torque switching of an antiferromagnetic metallic heterostructure
Authors: DuttaGupta Samik , Kurenkov A. , Tretiakov Oleg A. , Krishnaswamy G. , Sala G. , Krizakova V. , Maccherozzi F. , Dhesi S. S. , Gambardella P. , Fukami S. , Ohno H.
Published: November 2020

The ability to represent information using an antiferromagnetic material is attractive for future antiferromagnetic spintronic devices. Previous studies have focussed on the utilization of antiferromagnetic materials with biaxial magnetic anisotropy for electrical manipulation. A practical realization of these antiferromagnetic devices is limited by the requirement of material-specific constraints. Here, we demonstrate current-induced switching in a polycrystalline PtMn/Pt metallic heterostructure. A comparison of electrical transport measurements in PtMn with and without the Pt layer, corroborated by x-ray imaging, reveals reversible switching of the thermally-stable antiferromagnetic Néel vector by spin-orbit torques. The presented results demonstrate the potential of polycrystalline metals for antiferromagnetic spintronics.
A comparative genomics multitool for scientific discovery and conservation
Authors:   Zoonomia Consortium, Genereux Diane P. , Serres Aitor , Armstrong Joel , Johnson Jeremy , Marinescu Voichita D. , Murén Eva , Juan David , Bejerano Gill , Casewell Nicholas R. , Chemnick Leona G. , Damas Joana , Di Palma Federica , Diekhans Mark , Fiddes Ian T. , Garber Manuel , Gladyshev Vadim N. , Goodman Linda , Haerty Wilfried , Houck Marlys L. , Hubley Robert , Kivioja Teemu , Koepfli Klaus-Peter , Kuderna Lukas F. K. , Lander Eric S. , Meadows Jennifer R. S. , Murphy William J. , Nash Will , Noh Hyun Ji , Nweeia Martin , Pfenning Andreas R. , Pollard Katherine S. , Ray David A. , Shapiro Beth , Smit Arian F. A. , Springer Mark S. , Steiner Cynthia C. , Swofford Ross , Taipale Jussi , Teeling Emma C. , Turner-Maier Jason , Alfoldi Jessica , Birren Bruce , Ryder Oliver A. , Lewin Harris A. , Paten Benedict , Marques-Bonet Tomas , Lindblad-Toh Kerstin , Karlsson Elinor K.
Published: November 2020

The Zoonomia Project is investigating the genomics of shared and specialized traits in eutherian mammals. Here we provide genome assemblies for 131 species, of which all but 9 are previously uncharacterized, and describe a whole-genome alignment of 240 species of considerable phylogenetic diversity, comprising representatives from more than 80% of mammalian families. We find that regions of reduced genetic diversity are more abundant in species at a high risk of extinction, discern signals of evolutionary selection at high resolution and provide insights from individual reference genomes. By prioritizing phylogenetic diversity and making data available quickly and without restriction, the Zoonomia Project aims to support biological discovery, medical research and the conservation of biodiversity.
A methodology for predicting tissue-specific metabolic roles of receptors applied to subcutaneous adipose
Authors: Somekh Judith
Published: November 2020

The human biological system uses ‘inter-organ’ communication to achieve a state of homeostasis. This communication occurs through the response of receptors, located on target organs, to the binding of secreted ligands from source organs. Albeit years of research, the roles these receptors play in tissues is only partially understood. This work presents a new methodology based on the enrichment analysis scores of co-expression networks fed into support vector machines (SVMs) and k-NN classifiers to predict the tissue-specific metabolic roles of receptors. The approach is primarily based on the detection of coordination patterns of receptors expression. These patterns and the enrichment analysis scores of their co-expression networks were used to analyse ~ 700 receptors and predict metabolic roles of receptors in subcutaneous adipose. To facilitate supervised learning, a list of known metabolic and non-metabolic receptors was constructed using a semi-supervised approach following literature-based verification. Our approach confirms that pathway enrichment scores are good signatures for correctly classifying the metabolic receptors in adipose. We also show that the k-NN method outperforms the SVM method in classifying metabolic receptors. Finally, we predict novel metabolic roles of receptors. These predictions can enhance biological understanding and the development of new receptor-targeting metabolic drugs.
Mechanics and physics of a glass/particles photonic sponge
Authors: Dubernet M. , Bruyer E. , Gueguen Y. , Houizot P. , Hameline J. C. , Rocquefelte X. , Rouxel T.
Published: November 2020

A glass containing mechanoluminescent crystalline particles behaves as a photonic sponge: that is to say it fills up with trapped electrons when exposed to UV light, and it emits light when submitted to a mechanical loading, similar to a sponge soaked with water that is wringed under mechanical action! A major finding of the present study is that the elasto-mechanoluminescence effect showing up on unloading is governed by the deviatoric part of the applied stress (no effect under hydrostatic pressure). Furthermore, the structural source for this phenomenon was elucidated by a detailed density functional theory analysis of the e− energetics at the possible oxygen vacancy sites within the crystalline phase. Both the e− trapping and detrapping processes under load could be explained. An analogy with hydraulic circuits and the rheology of viscoelastic media was successfully introduced to pave the way to a constitutive law for the mechano-optical coupling phenomenon.
Entanglement and entropy squeezing in the system of two qubits interacting with a two-mode field in the context of power low potentials
Authors: Khalil E. M. , Berrada K. , Abdel-Khalek S. , Al-Barakaty A. , Peřina J.
Published: November 2020

We study the dynamics of two non-stationary qubits, allowing for dipole-dipole and Ising-like interplays between them, coupled to quantized fields in the framework of two-mode pair coherent states of power-low potentials. We focus on three particular cases of the coherent states through the exponent parameter taken infinite square, triangular and harmonic potential wells. We examine the possible effects of such features on the evolution of some quantities of current interest, such as population inversion, entanglement among subsystems and squeezing entropy. We show how these quantities can be affected by the qubit-qubit interaction and exponent parameter during the time evolution for both cases of stationary and non-stationary qubits. The obtained results suggest insights about the capability of quantum systems composed of nonstationary qubits to maintain resources in comparison with stationary qubits.