bluuebunny/crossref_metadata_2025 huggingface dataset:
Uma formação para EJA sobre educação financeira aportada na Etnomatemática e na Teoria da Aprendizagem Significativa
Authors: Viana Wanderson Felix , Silva José Roberto da , Rufino Maria Aparecida da Silva
Published: December 2023

O artigo em questão é um recorte de uma pesquisa desenvolvida no âmbito do Mestrado Profissional em Educação da Universidade de Pernambuco (UPE), cujo intuito é a preparação de professores na criação de caminhos para intervenção na Educação de Jovens e Adultos. Neste estudo, além de uma fundamentação adequada em termos do objeto matemático de ensino, preconiza-se que o professor precisa ter o seu fazer docente aportado nos referenciais epistemológico e pedagógico, os quais só foram definidos após a análise das percepções de um grupo de seis professores que atuam nessa modalidade de ensino. O levantamento das compreensões dos professores sobre suas práticas docentes foi realizado por meio de um questionário diagnóstico e da elaboração/entrega de um plano de aula sobre Juros Simples na perspectiva de uma Educação Financeira. O propósito de modificar a realidade educacional a partir do olhar que os envolvidos têm sobre suas ações/interações remete a uma natureza investigativa de cunho qualitativo, no viés da pesquisa-ação. Como resultado, indica-se que uma formação pautada epistemologicamente na Etnomatemática e pedagogicamente no marco ausubeliano atenderia às necessidades dos participantes, corroborando a premissa inicial, trazida neste estudo, de aportar o fazer docente nos enfoques teóricos matemático, epistemológico e pedagógico.
Os discursos em torno da ideologia de gênero, o kit gay e a homofobia no curso de Pedagogia em uma universidade estadual da Bahia
Authors: Cirqueira Nilson Sousa , Santana José Valdir Jesus de , Pereira Reginaldo Santos
Published: December 2023

Este artigo tem como foco de análise problematizar os discursos sobre gênero e docência a partir dos enunciados dos (as) discentes e docentes do curso de Pedagogia da UESB. Utilizamos autores como Louro (2011), Foucault (1988, 2008), Miskolci (2007, 2016), Miskolci e Campana (2017), Oliveira e Oliveira (2018a, 2018b), Paraíso (2004, 2018), Rodrigues e Facchini (2018), Borrillo (2010), Junqueira (2007), Carrara (2015), Britzman (1996), Arruda e Soares Júnior (2021), dentre outros. As perspectivas que organizam as análises amparam-se nos estudos pós-críticos das relações de gênero, sexualidade e educação. Como técnicas de produção de discursos foram utilizados a entrevista semiestruturada e o grupo focal com 6 (seis) docentes (1 homem e 5 mulheres) e 10 (dez) discentes (8 mulheres e 2 homens) do curso de Pedagogia. Constatamos que as falas dos sujeitos se encaminham mais para uma discussão em torno das sexualidades; é como se falar sobre gênero fosse falar de sexualidade e das questões que a envolvem. O discurso da “ideologia de gênero” e do “kit gay” ganhou visibilidades nas falas dos sujeitos, são slogans que têm provocado um pânico moral em todo o país e prejudicado o debate a respeito das questões de gênero e sexualidade.
Gestão escolar democrática e desafios da interpretação e aplicação da legislação em escolas da rede municipal de Caiçara, Rio Grande do Sul
Authors: Silva Fabiana Regina da , Pasinato Darciel , Reis Cristiane Medianeira da Silva
Published: December 2023

Este artigo propõe uma reflexão sobre a gestão escolar democrática e os desafios da interpretação e da aplicação da legislação em escolas da rede municipal de Caiçara, Rio Grande do Sul, sob a orientação, mantença e gestão da Secretaria Municipal de Educação. Esta pesquisa se justifica pela necessidade de ampliar a produção acerca da temática, especialmente no que tange aos pequenos municípios brasileiros, distantes das capitais, considerando a carência de análises a esse respeito. Para isso, esta investigação se fundamenta na coleta de narrativas de gestoras escolares, com base na abordagem teórica e metodológica do estudo de caso, a partir de questionários contendo questões semiestruturadas. Ao realizar esta pesquisa focando a aplicação da lei de gestão escolar democrática, o processo levou, por exemplo, a estabelecer relações dialógicas com gestoras escolares em atuação, bem como a inteirar-se dos desafios e das realidades distintas, da falta de efetivo conhecimento sobre a legislação e então da não plena aplicação desta em âmbito municipal.
DISASTER RESILIENT VILLAGES AS A LEVEL FOR TSUNAMI PREPAREDNESS
Authors: Widodo Paulus Punjung , Handayani Vitria Wuri , Kurniawan Dedi
Published: December 2023

Indonesia's geographical location which is located between three plates makes Indonesia a country that is prone to disasters, one of which is the threat of a tsunami disaster. Tulungagung, which is located on the southern coast of the island of Java, is one of the areas prone to tsunamis. The new disaster management paradigm is focused on efforts to reduce disaster risk. Strengthening village capacity by creating a Disaster Resilient Village (Destana), is one of the effective efforts to reduce disaster risk. The purpose of this study was to provide an overview of the readiness of the Besole hamlet, Tulungagung Regency. The research method used is descriptive research by collecting the results of in-depth interviews with the Destana community activists in Besole hamlet, Tulungagung Regency. The results obtained from this study were participation, the Besole Village community was involved from the beginning, namely from the start of preparation for the establishment of the Destana by conducting disaster risk studies, making evacuation route maps, determining gathering points, as well as installing and maintaining early warning system tools. For the role of participation, there is no sustainability in the community, readiness is good and management is good.

Keywords: Disaster Resillent Village, Tsunami
MINIMIZE WASTE MOTION IN THE PRODUCTION PROCESS LAYOUT
Authors: Paleva Fenza Gusti Naufal , Gusminto Eka Bambang , Nadia Fiona Niska Dinda , Nusbantoro Ariwan Joko , Akbar Rasyidi Faiz
Published: December 2023

This study aims to determine the factors that cause waste motion and provide a proposed improvement and improvement design to minimize the factors that cause waste motion in the production process of UD Putera Sroedji Jember. UD Putera Sroedji is a medium-scale company in the field of rice production in the Jember area. The problems found at UD Putera Sroedji are the production flow that is not suitable in general and the distance between departments is quite far. These two things are one of the causes of the company's waste motion. The data was obtained by making observations to observe the flow of the production process as well as measuring distance and time. Data analysis used ARC, ARD and Kaizen methods. The results show that the efficiency level given from the two production process lines, namely the proposed layout will be estimated to be able to reduce the production distance of line 1 along 31.25 meters or more efficiently by 30.65% with time savings of 2.828.75 seconds. 2 along 45.4 m or more efficient by 38.07% with a time saving of 3,980.15 seconds.
THE RISK OF TRANSMISSION OF COVID-19, COMMUNITY STIGMA, THE AVAILABILITY OF PPE AS A STRESS TRIGGER FOR HEALTH WORKERS
Authors: Hidayat Arif Fatah , Iswati Sri
Published: December 2023

In the midst of the Covid-19 pandemic, the role of health workers is very important. The high risk of transmission causes stress for them. The aim of the research is to empirically determine the influence of the risk of Covid-19 transmission, public stigma, and the availability of PPE on the stress of health workers in hospitals. Using a quantitative approach, the cross section with a sample of 122 was tested with multinomial logistic regressions. Univariate results show that the risk of transmission is low, public stigma is moderate, PPE availability is high and stress is moderate. The results of the bivariate analysis show that the risk of Covid-19 transmission has a positive effect, community stigma has a positive effect, and the availability of PPE has a positive effect on health worker stress, all of which are significant. Multivariate analysis results indicate that all independent variables have a significant effect on health worker stress. The risk variable for transmitting Covid-19 is the most dominant. Screening for the risk of Covid-19 transmission, complete personal protective equipment, and positive stigma can provide health workers with a sense of security so that the risk of stress can be minimized.
MORPHOLOGICAL COMPARISON OF Octolasmis sp. ECTOPARASITES INFESTING THE GILLS OF SCALLOPED SPINY LOBSTER (Panulirus homarus) WITH DIFFERENT FIXATIVE SOLUTIONS
Authors: Yusuf Taufik Hidayat  , Kismiyati  , Muhamad Amin
Published: December 2023

Octolasmis is a type of ectoparasite  which is often found on the gills of lobsters. Octolasmis can also be a threat to lobster populations and can even cause high mortality rates. This study aims to detect the effect of different fixative solutions on the morphological characters of Octolasmis infesting the gills of scalloped spiny lobsters (Panulirus homarus). Samples of Octolasmis were collected from the gills of wildly-caught scalloped spiny lobsters in East Lombok, West Nusa Tenggara. The samples were immersed separately in two different fixative solution which are either absolute ethanol or formalin solution. After 7 days, morphological analysis of Octolasmis was analysed using an integrated optilab stereo binocular microscope and a lucida camera. The result showed that there were significant differences in the morphological condition of Octolasmis sp. including skin colour, organ appearance and size of the Octolasmis. In general, the result showed that formalin is better fixative solution.
Zero knowledge registration of PKI authentication for symbiotic security in FIDO IoT
Authors: Bartsch Witali , Millwood Owen , Kavun Elif Bilge
Published: December 2023

In this paper, we critically discourse on the current Fast IDentity Online specification, its underlying security layer and the resulting misconceptions or even weaknesses. We juxtapose the presented view against some of the fundamental and long-standing public key infrastructure problems such as the initial enrolment of identities and their keys (e.g., X.509v3 certificates). We then observe a novel approach of zero-knowledge initial enrolment of resource-constrained Internet of Things devices and investigate how its idea of symbiotic security, i.e., a consistent and consolidated cooperative design which involves all architectural building blocks such as software, hardware, networks, and processes, can contribute to the new Fast IDentity Online Internet of Things specification in the making. Finally, we suggest by way of an outlook or future work how this already modular security-by-design mindset can be further enhanced through a dynamic management system to keep cryptographic keys in volatile memory only. The idea is also based on a symbiotic connection between hardware and software to create a number of added benefits from the security perspective.
The influence of Muslim fashion influencers on purchase intention mediated by attitude towards the advertising and brand attitude in the Muslim fashion industry in Indonesia
Authors: Avrillia Micky Dita , Moeljadi  , Hapsari Raditha Dwi Vata
Published: December 2023

Although numerous studies have been conducted on the impact of influencers on purchase intention. Researchers are divided into two factions, each yielding distinct outcomes. The initial group of researchers discovered that influencers exert a substantial impact on the desire to make a purchase. Conversely, the second group of researchers discovered that influencers do not have a substantial impact on purchase intention. According to the idea of planned behavior, a person's subjective opinions about their preferences or aversions have an impact on their decision to take action. This study focuses on Instagram users that follow Muslim fashion accounts such as Heaven Lights, Vanilla Hijab, Wearing Klambi, and Heylocal. These accounts identify the research objects as the products they offer. The sample technique employed is non-probability, specifically utilizing a purposive sampling approach. A total of 170 respondents were surveyed. The employed methodology for data collection involves the dissemination of questionnaires. The data analysis technique employed was Structural Equation Modeling-Partial Least Squares (SEM-PLS) utilizing smartPLS 3.0 software. The findings indicated that influencers did not have a substantial impact on the intention to make a purchase. The factors of attitude towards advertising and brand attitude completely mediate the influence of influencers on purchase intention. These findings corroborate the findings of the research team that concluded that influencers do not have a substantial impact on purchase intention. The findings of this study also demonstrate the crucial significance of the mediating factors' attitude towards advertising and brand attitude in the impact of influencers on purchase intention.
Revitalizing Pennsylvania's infrastructure: local public-private partnerships as the key to bridging the gap with a case study for local public-private transportation partnerships
Authors: Setiawan Bekrim , Thornton Victoria , Susanto Ari Dwi
Published: December 2023

Pennsylvania's aging transportation infrastructure has long been a cause for concern, with bridges, highways, and other vital components approaching the end of their serviceable lifespans. The state's infrastructure, one of the nation's oldest, is in dire need of repair and replacement, particularly in the case of bridges, many of which are over 50 years old and in poor condition. However, the financial investment required for this task is substantial, posing challenges within the state's budget constraints. To address this infrastructure crisis, an amendment to Pennsylvania's existing legislation, Act 88, is proposed. This amendment would permit local governments to engage in Public-Private Transportation Partnerships (P3s), leveraging private sector financial resources and expertise. Such local government Transportation P3s have the potential to alleviate the state's infrastructure and financial woes. Currently, Act 88 prohibits municipal governments from participating in these partnerships, hindering the Commonwealth's ability to secure private funding and expertise when public resources are limited. This study aims to address the structural deficiencies in Pennsylvania's transportation infrastructure and its $2.2 billion financial deficit, which hampers repair and improvement efforts. The study employs a descriptive, multi-case analysis to investigate how an amendment to Act 88 could enable local municipalities to engage in P3 transportation projects. These partnerships could provide solutions to budgetary and funding challenges, particularly in the context of locally owned bridge repair and replacement projects. The selected cases are evaluated against various performance criteria, such as value, pricing, budgeting, public accountability, regulatory control, and capacity, offering a comprehensive assessment of the potential benefits of local government participation in P3 transportation projects.
Crafting digital business ecosystems for cultural and creative industries
Authors: Hsu Shang-Fang , Wang Xin-Yao , Yang Chia-Han , Liou Shyhnan
Published: December 2023

The Cultural and Creative Industries (CCI) thrive on innovation and creativity, necessitating robust cross-domain collaboration among diverse stakeholders. However, the current state of CCI co-creation mechanisms is marked by inadequacies. The primary objective is to provide practical and effective strategic guidance for co-creation endeavors within the dynamic CCI landscape. This study employs the Root Cause Analysis (RCA) method to identify and analyze critical elements for industrial co-creation, offering a comprehensive framework for understanding the intricacies of co-creation processes. The Cultural and Creative Industries Digital Business Ecosystem (CCI-DBE) model is then developed to encompass four foundational pillars: participation of multiple stakeholders, mechanism of co-creation, uniqueness of consumer experience, and output of co-created value. Participation of multiple stakeholders recognizes the importance of integrating perspectives from content creators, other companies, suppliers, and customers. The mechanism of co-creation delves into the necessity of a robust platform, supported by technological infrastructure, to facilitate seamless resource and knowledge exchange. The uniqueness of consumer experience emphasizes the need for tailoring offerings to meet consumers' unique experiential and meaningful needs. Output of co-created value focuses on enhancing product novelty, resource sharing, communication efficiency, information interaction, and cross-domain integration. This CCI-DBE model not only contributes to academic discourse but also provides actionable insights for practitioners seeking to navigate and enhance the co-creation process within the evolving CCI landscape. It stands as a valuable guide for fostering innovation, collaboration, and strategic alignment in the CCI sector.
Macroeconomic and financial dimensions influences on Indonesia's property and real estate companies value (2017-2022)
Authors: Devania Yurisafira Olivia , Sunitiyoso Yos , Rahadi Raden Aswin
Published: December 2023

This paper investigates the relationship between macroeconomic factors, firm financial position, and firm value in Indonesia's property and real estate sector from 2017 to 2022. The property and real estate sectors significantly influence Indonesia's economic growth. Nevertheless, the real estate sector has encountered significant obstacles in recent years, notably during the COVID-19 pandemic, due to volatility in interest rates, high construction costs, and the sluggish property market. This study aims to address the existing research gap by investigating the relationship between macroeconomic indicators, including GDP growth, inflation rates, and interest rates, as well as financial factors, such as profitability and leverage, on the industry’s firm value over a specified timeframe. Using panel data regressions, the study analyzes 162 observations from 27 listed property and real estate companies. The empirical findings demonstrate that property and real estate firms have the potential to enhance their overall performance and increase shareholder value by considering the interconnectedness of economic conditions and the financial position of the firm. Profitability emerges as a significant predictor of firm value, while the selected macroeconomic factors have significant and insignificant effects on the valuation of firms. Meanwhile, since this industry has substantial leverage, this variable does not affect firm value. This study also highlights that the critical component that drives the evaluation of a firm's value is heavily influenced by the specifics of the industry and the regulatory framework in which the business operates.
The role of value co-creation in sustaining partner loyalty in B2B business: a service-dominant logic approach
Authors: Ahmad Putra Rendy , Budiyanto  , Suhermin
Published: December 2023

The primary aim of this research is to investigate the impact of value co-creation utilizing the Service-Dominant Logic (SDL) approach on partner satisfaction, which subsequently fosters loyalty, commitment, and trust among B2B organizations. The present study examined petrogenic partners manufactured by PT Petrokimia Gresik, an Indonesian government-owned enterprise tasked with assisting in the production of organic fertilizers. The present study employed a survey methodology to gather data from 139 petrogenic supplier partners. As a form of SDL, value co-creation with supply partners through training, development programs, knowledge sharing, and standard-setting influences their satisfaction with the cooperative relationship, which ultimately increases their commitment and loyalty to PT Petrokimia Gresik and fosters trust. The findings of this research indicate that business-to-business (B2B) organizations must prioritize their relationships with business partners, particularly suppliers. By engaging suppliers in the value co-creation process, organizations can foster supplier loyalty and satisfaction, ultimately leading to the achievement of high-quality production outcomes.
Optimization of reinforced concrete beam using hybrid algorithms with multi-objective function as CO2 emission and cost
Authors: Çoşut Muhammed , Bekdaş Gebrail , Nigdeli Sinan Melih
Published: December 2023

In this study, algorithms with two objective functions are defined considering the TS500 (2000) (Reinforced concrete structures design and construction rules) and TBDY (2018) (Turkey Building Earthquake Regulation) standards for rectangular beam design. These objective functions were determined as CO2 emission and cost. Optimizations were performed in MATLAB program using the Hybrid Algorithm of Teaching-Learning Based Optimization and Jaya Algorithm. In the case of using two objective functions, cases were created by multiplying the coefficient values found in the objective function according to the formula with the cost and CO2 emission values at different rates in order to prevent CO2 emission which is one of the biggest problems for the world. In the objective function, each rate used for CO2 and cost is implemented in a manner that increases or diminishes the impact of these values. In this way, comparisons were made between the cross-section dimensions to be formed according to not only impact rates but also the reinforcement area to be used, the CO2 emission and cost values that will arise as a result of these. Impact rates are related to cost and CO2 rate in the objective function, and the total rate is chosen as 1. Impact rates for cost are chosen as 0.1, 0.3 along with 0.5, and comparisons between the results are checked.  In addition, recyclable and non-recyclable steel with different properties were used in separate analyses and the values were compared. Since the CO2 rate released by the non-recyclable steel is very high compared to the recyclable steel, the results show that the CO2 emission value is higher and this causes the objective function value to increase.
An overview on the hazards and handling methods of construction and demolition wastes: Special focus on recycled concrete aggregates
Authors: Derki Alhamza , Akpınar Pınar
Published: December 2023

With the demand increased in construction activities within the last century, several scientific research studies have been focusing on different aspects of construction and demolishing wastes, while considering the severity of environmental problems that they cause. This work presents the results of out an extensive literature survey in order to provide an overview on the hazards and handling methods of construction and demolishing wastes. Results of this literature review indicate that landfilling has been the most commonly used method, even though the recycling of the construction and demolishing wastes was found out to be the most environmentally-friendly solution. It was observed that groundwater and soil may be heavily affected by the leaching constituents of landfilled construction wastes. On the other hand, using these wastes in the form of recycled concrete aggregates was observed to eliminate these hazards. The results of literature survey pointed out that the use of demolished concrete wastes as recycled concrete aggregates could be widely adopted by construction sector only if the resulting concrete is of satisfactory quality. Hence, information on different quality aspects of concrete made of recycled concrete aggregates are presented systematically as a clear guide in this work, to verify its feasibility as an environment-friendly waste elimination method.
Abundance of microplastic in sediment around the west coast of Situbondo, East Java
Authors: Yona Defri , Nabila Risda Ayu , Nabila Risda Ayu , Fuad Mochamad Arif Zainul , Nabila Risda Ayu , Iranawati Feni , Fuad Mochamad Arif Zainul , Fuad Mochamad Arif Zainul , Iranawati Feni , Iranawati Feni
Published: December 2023

Microplastic pollution has become a serious issue worldwide. Once it enters the environment, microplastics could accumulate in the water column and sediment. This study aimed to analyze the occurrence of microplastics in the beach sediments along the western coast of Situbondo, East Java. Sediment samples were collected in the strandline areas from seven different beaches that received the high impact of human activities. In the laboratory, sediment samples were oven-dried and weighed, density separation was performed using NaCl solution, degradation of organic matter was conducted using H2O2 30% and microplastic particles were identified using a microscope. In total, 1041 microplastic particles were retrieved from 21 sediment samples consisting of fiber (50 %), fragment (37 %), microbeads (11 %), and film (2 %). Microplastics found in this study consists of blue color (49 %), red (26 %), white (11 %), brown (7 %), and other colors such as yellow, black, green, and transparent with a percentage between 1?3 %. Microplastics with a size of < 300 µm dominate the result of this study. Microplastic abundances were found in the range of 204.52?492.50 particles/kg sediment sample. In each sampling location, the types of microplastic were found in a different pattern. Fiber and fragments were found in all sampling sites, while film and microbeads were found only in specific sites. This study showed that several factors, such as plastic sources and hydro-oceanography parameters, influenced the occurrence of microplastics in the sampling sites. In order to address microplastic pollution in the marine environment, plastic waste management strategies are required.Keywords: Fishing port, Mangrove, Marine Pollution, Plastics, Tourism
Alternative and Sustainable Protein Sources in Pig Diet: A Review
Authors: Lestingi Antonia
Published: December 2023

Abstract: The search for alternative protein sources to soy-bean meal (SBM) in animal feeding is a strategic objective to reduce production costs and contribute to a sustainable animal produc-tion. Spirulina, due to the high protein content, has emerged as a potential cost-effective, sus-tainable, viable and high nutritional value food resource for many animal species. Insect larvae (Tenebrio molitor and Hermetia illucens) are also considered potential alternatives to SBM, given their high edible percentage of almost 100%, as well as a protein value higher than that of vegetable proteins. Rapeseed meal and grain legumes, such as faba beans, peas, lupins and chickpea can also be used as locally producible protein ingredients. This study reviews the nutritional value of these potential alternatives to SBM in pig diets, effects on animal perfor-mance, digestion, immune system, physicochemical and sensorial characteristics of meat, in-cluding processed meat products of pork. Limits on their use in pig feeding are also reviewed to indicate gaps to be filled in future research on the supplementation level of these potential al-ternative protein sources into pig diets.
Nucleobase-Containing Molecules and Their Self-Assembly Properties for Gel Formation: A Review
Authors: Scognamiglio Pasqualina Liana , Vicidomini Caterina , Roviello Giovann. N.
Published: December 2023

Nucleobase-containing molecules are compounds essential in biology due to the fundamental role of nucleic acids, and in particular G-quadruplex DNA and RNA in life. Moreover, some molecules different from nucleic acids isolated from different vegetal sources or microorganisms show nucleobase moieties in their structure. Nucleoamino acids and peptidyl nucleosides belong to this molecular class. Closely related to the above, nucleopeptides also known as nucleobase-bearing peptides are chimeric derivatives of synthetic origin and more rarely isolated from plants. Herein the self-assembly properties of a vast number of structures, belonging to the nucleic acid and nucleo amino acid/nucleopeptide family, is explored in the light of the recent scientific literature. Moreover, several technologically relevant properties such as the hydrogelation ability of some of the nucleobase-containing derivatives are reviewed in order to open the door to future experimental investigations of newly-inspired nucleobase-driven hydrogels. Nucleobase-containing molecules, such as mononucleosides, DNA, RNA, quadruplex (G4)-forming oligonucleotides and nucleopeptides, are paramount in gel and hydrogel formation owing to their distinctive molecular attributes and ability to self-assemble in biomolecular nanosystems with the most diverse applications in different fields of biomedicine and nanotechnology. In fact, these molecules and their gels present numerous advantages, underscoring their significance and applicability in both material science and biomedicine. Their versatility, capability for molecular recognition, responsiveness to stimuli, biocompatibility, and biodegradability collectively contribute to their prominence in modern nanotechnology and biomedicine. In this review, we emphasize the critical role of nucleobase-containing molecules of different nature in pioneering novel materials with multifaceted applications highlighting their potential in therapy, diagnostics, and new nanomaterials fabrication as required in order to address the numerous current biomedical and nanotechnological challenges.
Switching On/Off Amyloid Plaque Formation in Transgenic Animal Models of Alzheimer’s Disease
Authors: Kozin Sergey A. , Kechko Olga I. , Adzhubei Alexei A. , Makarov Alexander A. , Mitkevich And Vladimir A.
Published: December 2023

A hallmark of Alzheimer’s disease (AD) are the proteinaceous aggregates formed by the amyloid-beta peptide (Aβ) that is deposited inside the brain as amyloid plaques. The accumulation of aggregated Aβ may initiate or enhance pathologic processes in AD. According to the amyloid hypothesis any agent that has the capability to inhibit Aβ aggregation and/or destroy amyloid plaques represents a potential disease modifying drug. In 2023, a humanized IgG1 monoclonal antibody (lecanemab) against the Aβ soluble protofibrils was approved by US FDA for AD therapy thus providing compelling support to the amyloid hypothesis. To acquire a deeper insight on the in vivo Aβ aggregation, various animal models, including aged herbivores and carnivores, non-human primates, transgenic rodents, fish and worms are widely exploited. This review is based on the recent data obtained using transgenic animal AD models and presents experimental verification of the critical role in Aβ aggregation seeding of the interactions between zinc ions, Aβ with the isomerized Asp7 (isoD7- Aβ) and the α4β2 nicotinic acetylcholine receptor.
Fractional Order Mathematical Modelling of HFMD Transmission via Caputo Derivative
Authors: Mohandoss Aakash , Chandrasekar Gunasundari , Meetei Mutum Zico , Msmali Ahmed H.
Published: December 2023

In this paper, we propose to explore a nonlinear fractional mathematical model of HFMD- Hand Foot Mouth Disease with vaccinated compartment. Firstly, we prove the non negativity and boundedness for the fractional order dynamical model. The system’s existence and uniqueness are studied using the formulation of the Caputo derivative operator. The fixed-point approach was used to get results indicating the presence of at least one solution. In numerical simulation, we obtained the approximate solution by using fractional Euler method.
Neglected Effective Early Therapies against COVID-19: Focus on Functional Foods and Related Active Substances. A Review
Authors: Donzelli Alberto
Published: December 2023

The official recommendations to manage COVID-19 in the outpatient setting focus on high-cost drugs (remdesivir, nirmatrelvir-ritonavir, molnupiravir), suffering from many problems.
Therefore, one may consider also other treatments meeting these criteria:
• promising effectiveness, based on favorable randomized controlled trials (RCTs) of sufficient validity. Even without definitive evidence, physicians and informed patients can consider them if they are also:
• safe, to the state of knowledge
• with a very favorable opportunity cost
• biologically plausible/not implausible
• accessible
• without major commercial sponsors in the trials promoting them, and with researchers without major conflicts of interests.
The main focus is on a limited group of functional foods and some their active ingredients, with further mention of other substances of different origin, yet fully meeting all the aforementioned criteria.
The functional foods and substances described and discussed certainly do not cover all the known effective therapies for COVID-19 (in one case also for Long-COVID), but the only therapies proposed in this paper currently satisfy all the above criteria.
The supporting scientific evidence will favor meta-analyses of RCTs that include the most definitive outcome: all-cause mortality, i.e. the outcome that most fully informed people tend to prioritize. Furthermore, the reported evidence favors clinical studies of the most valid design, i.e. RCTs.
WAVE2 is a vital regulator in myogenic differentiation of progenitor cells through the mechanosensitive MRTFA-SRF axis
Authors: Nguyen Mai Thi , Ly Quoc Kiet , Kim Hyun-Jung , Lee Wan
Published: December 2023

Skeletal myogenesis is an intricate process involving the differentiation of progenitor cells into myofibers, which is regulated by actin cytoskeletal dynamics and myogenic transcription factors. Although recent studies have demonstrated the pivotal roles of actin-binding proteins (ABPs) as mechanosensors and signal transducers, the biological significance of WAVE2 (Wiskott-Aldrich syndrome protein family member 2), an ABP essential for actin polymerization, in myogenic differentiation of progenitor cells has not been investigated. Our study provides important insights into the regulatory roles played by WAVE2 in the myocardin-related transcription factor A (MRTFA)-serum response factor (SRF) signaling axis and differentiation of myoblasts. We demonstrate that WAVE2 expression is induced during myogenic differentiation and plays a pivotal role in actin cytoskeletal remodeling in C2C12 myoblasts. Knockdown of WAVE2 in C2C12 cells reduced filamentous actin levels, increased globular actin accumulation, and impaired the nuclear translocation of MRTFA. Furthermore, WAVE2 depletion in myoblasts inhibited the expression and transcriptional activity of SRF and suppressed cell proliferation in myoblasts. Consequently, WAVE2 knockdown suppressed myogenic regulatory factors (i.e., MyoD, MyoG, and SMYD1) expressions, thereby hindering the differentiation of myoblasts. Thus, this study suggests that WAVE2 is essential for myogenic differentiation of progenitor cells by modulating the mechanosensitive MRTFA-SRF axis.
Theoretical Investigation on Selected 3-amino-5- [(2,4,6-trinitrophenyl)amino]-1H-1,2,4-triazole Salts with Perspective Energetic Anions
Authors: Tamuliene Jelena , Sarlauskas Jonas
Published: December 2023

The current work is dedicated to the search for new high-energy materials (HEMs) with improved characteristics which are gained through agglomeration with salts. The research was performed by Becke’s three-parameter hybrid functional approach with non-local correlation provided by Lee, Yang, and Parr and cc-pVTZ basis set. The geometry, total energy, and heat of formation of the most stable compounds forming due to 3-amino-5-[(2, 4, 6-trinitrophenyl) amino]-1H-1, 2, 4-triazole (APATO) within salts selected were obtained to foresee its influence on resistance to shock stimuli, detonation pressure, and velocity of the materials under study. Results obtained allow us to foresee that only agglomeration with precise salts could lead to significant improvement in the stability of the specific high-energy materials and the resistance to shock stimuli. We also show that the agglomeration leads to better energetic properties of the above compound, although the improvement could be insignificant in some cases.
The Urgency of Reforming the Death Penalty Policy for Narcotics Distributors Post the Constitutional Court Decision Number 2-3/PUU-V/2007
Authors: Apriyanti R.A. Indah
Published: December 2023

The most questioned severe punishment that can be given for someone is death penalty as with death penalty someone’s existence can be vanished and it is irrevokeable. Since there is no way for turning back the time and brings the life of the person that has already executed. With the establishment of death penalty, Article 28J Paragraph (1) of the 1945 Constitution and Article 29 Paragraph (2) of the Universal Declaration of Human Rights cannot be enforced. Basic Rights directly bind the three areas of state power to obey and respect them. The application of death penalty for narcotics dealers in Indonesia is not only limited to producing legal products, but the implementation of these laws also imposed by the state or the Indonesian government. The issue of whether or not the death penalty is appropriate remains and continues in Indonesia. Nevertheless, The Constitutional Court of the Republic of Indonesia in its decision Number 2—3/PUU-V/2007stated that death penalty is not against Article 28A and Article 28I 1945 Constitution. Hence, the act of distributing narcotics has also violated the human rights of many people in a nation because it can have a devastating impact on future generations of youth. This Normative legal research will be focus on:

1.    Whether the constitutional interpretation regarding the death policy for narcotics dealers in the Constitutional Court Decision Number 2—3/PUU-V/2007 according to the review of non-derogable rights?

2.    The need to reforms towards the death penalty policy for narcotics dealers in Indonesia?
Pengaturan Pengupahan Pekerja/Buruh Usaha Mikro dan Kecil Dalam Perspektif Teori Keadilan John Rawls
Authors: Sisma Annisa Fianni , Subekti Rahayu
Published: December 2023

Pengaturan mengenai pengupahan pekerja/buruh usaha mikro dan kecil diubah dengan adanya UU Cipta Kerja. Perubahan tersebut meliputi adanya pembebasan usaha mikro dan juga usaha kecil dari ketentuan UMP dan kabupaten/kota. Hal ini dapat menyebabkan pengusaha mikro dan kecil bertindak sewenang-wenang meski diatur bahwa upah pekerja/buruh usaha mikro dan kecil harus dilaksanakan dengan ketentuan minimal 50% dari rata-rata konsumsi masyarakat skala tingkat provinsi dan harus sesuai dengan minimal 25% di atas garis kemiskinan di skala tingkat provinsi. Oleh karena itu, perlu diteliti terkait pengaturan pengupahan pekerja/buruh usaha mikro dan kecil ditinjau dari perspektif teori keadilan oleh John Rawls. Penelitian normatif ini menggunakan pendekatan pendekatan peraturan perundang-undangan dengan bahan hukum primer dan sekunder berupa UU No. 13/2003, PP No. 36/2021, PP No. 7/2021 dan lainnya. Hasil penelitian ini yakni pengaturan pengupahan pekerja/buruh usaha mikro dan kecil belum memenuhi kriteria keadilan menurut John Rawls. Sebab, ketimpangan sosial dan ekonomi belum memberi keuntungan untuk semua orang khususnya pihak-pihak yang kurang beruntung. Pengaturan terkait pengupahan untuk pekerja/buruh usaha mikro dan kecil hendaknya memberikan perlindungan hukum terhadapnya dari ketidakadilan. Pengaturan ini memberi celah pengusaha mikro dan kecil untuk menetapkan upah tanpa memberikan penghidupan yang layak dan perannya dalam perjanjian kerja yang dominan. Seharusnya, pengaturan pengupahan lebih melindungi dan tetap menentukan adanya upah minimum sebagai instrumen pengendalian karena pemerintah wajib memberikan perlindungan terhadap pekerja/buruh pada usaha mikro dan kecil.
Penguatan Perlindungan Masyarakat Hukum Adat Dayak Paser di Kabupaten Panajam Paser Utara Dari Dampak Pemindahan Ibukota Indonesia
Authors: Rahayu Sri Lestari , Mulyanto Mulyanto
Published: December 2023

The decision of the Indonesian government to move its capital from Jakarta to North Penajam Paser Regency (PPU) in East Kalimantan Province has affected the vulnerable local indigenous people (MHA). This study aims to determine the impact of this relocation and formulate a strategy that protects Dayak Paser in PPU Regency as a traditional community despite challenges from modern society. Historical and statutory approaches were used for literature documentation., while qualitative data analysis was based on inductive and deductive reasoning logic. The results showed that capital relocation affects Dayak Paser's existence in economics, environment, natural resources, environment, politics, livelihood, and security fields, though three strategies can be adopted for legal protection. These include drafting and ratifying a law on the State Capital for regulating the legal protection of indigenous people in the PPU Regency area, guaranteeing the determination of the legal standing of MHA automatically and permanent human rights for people of MHA origin. Therefore, the government and legislature should use these findings to formulate policies and regulations about the existence of the state capital. 
FORMATION OF MODELS AND METHODS FOR ANALYSIS OF STRESS-STRAIN STAND WITH CONTACT INTERACTIONS (REVIEW ARTICLE)
Authors: Zinchenko Olena
Published: December 2023

An analysis of the literature and developing models and methods for analyzing the stress-strain system based on the contact interaction between bodies has been conducted. The history of the development of models and methods of analysis of the stress-deformation mill with the protection of contact interaction is considered, which makes it possible to appy the postulates with the drive of what is not necessary: ​​the combination of different types of nonlinearities; transition to a variational formulation of the problem; protection of the surface of contacting bodies; establishment of the method of formalized parametric modeling simultaneously with the combined elements method. Therefore, it is necessary to develop the model, since, in view of the known previous models, they will operate from variable, rather than permanent, physical-mechanical influences on the material of the torsion shafts. It has been concluded that the methods for breaking up the stress-deforming machine, which have been formed, do not support many factors that influence on the elements of armored vehicles, so as not to give an adequate assessment of their value and efficiency durability. The need to move to a variable formulation of the problem and a formalized parametric modeling of processes and stages in the design research of elements of combat armored vehicles simultaneously from the combined element method has been considered. This will make it possible to organize the search for rational design and technological solutions for torsion shafts being part of light armored vehicles with high tactical and technical characteristics. In this case, it is necessary to ensure sufficient adequacy of the model and satisfactory efficiency in numerical investigations.
Keywords: light armored vehicle; tactical and technical characteristics; torsion shaft; stress-strain state; strength; durability; elastic-plastic deformation; contact interaction
Comprehensive assessment of the quality of laminated core of electrical machines by the high-frequency induction-vibration method
Authors: Chumak Vadim , Kovalenko Mykhaylo , Tymoshchuk Oksana , Ihnatiuk Yevhen , Kovalenko Iryna
Published: December 2023

In this work, the problem of assessing the quality of active parts of electric machines, in particular charged magnetic conductors, is considered. The essential diagnostic indicators of the actual state of the recruitment core were determined, namely specific losses during remagnetization and weakening of package pressing, which are associated with increased losses, decreased efficiency, violation of the thermal regime, etc. induction-measuring module for determining the level of inter-sheet insulation breakdown and the growth of losses in the core. It is recommended when loosening for small-sized magnetic conductors, impregnation of the weakened area with adhesive varnish and subsequent drying with a compressed core. Also, for cores of a small diameter, between the pressure washer and the extreme sheets of the core, drive textolite wedges every 2...4 teeth. When the pressing of the cores of large electric machines, in which the pressing is carried out by tension pins, is weakened, the pins are tightened. A two-dimensional field mathematical model of a charged magnetic core package was developed in order to estimate the distribution of the electromagnetic field and eddy currents and losses at different frequencies from 50 Hz to 10 kHz. It is proposed to use the analysis of the transient process when the magnetic flux changes in the magnetic circuit. To simplify the measuring scheme, it is proposed to use the process of switching the current in the excitation winding. With the help of the developed model, the calculation of transient modes was carried out on the example of the studied magnetic circuit. As an object of research, a mock-up of a stacked magnetic core was used, which is a set package of magnetic steel sheets used in magnetic cores of dry transformers of small and medium power. In order to combine the two methods, an installation was developed that allows checking the quality of pressing and the quality of inter-sheet insulation at the same time.
Improvement of the uniformity of the magnetic field inside a short solenoid by the end winding system
Authors: Getman Andriy , Konstantinov Oleksandr
Published: December 2023

Improving the level of homogeneity of the magnetic field in the middle of the working volume of a short solenoid makes it possible to improve devices for demagnetizing technical objects and studying the magnetic properties of materials. One of the means of increasing the level of homogeneity of the magnetic field in the middle of the solenoid is to approximate the shape of its winding to the closed surface. The use of a system of a solenoid and two end axisymmetric current windings with a common current source is proposed as such a surface. A mathematical model of the scalar potential of the magnetic field of such a system was built using spherical harmonic analysis, and functional dependences of the current density on each surface were obtained for its first harmonic, which is the dipole component of the magnetic field. Formulas for calculating the number of turns in the end windings and the geometric parameters of their arrangement and the simulated total magnetic field inside the proposed system are obtained. A comparative analysis of the homogeneity of the magnetic field created by a separate solenoid and a solenoid with end windings, depending on the geometry of the system, was conducted. The use of end windings significantly improves the uniformity of the magnetic field near the ends, especially on the axis of the solenoid. Due to this, the efficiency of the end windings significantly depends on the solenoid elongation indicator and allows you to increase the working volume by 5-20%, depending on this indicator. The proposed system makes it possible to obtain a magnetic field with a maximum deviation of 5% from uniformity for a solenoid elongation index of 2. As the elongation increases, the efficiency of the end windings decreases and for systems with an elongation of 10 or more, their use becomes impractical. The results of the analysis testify to the effectiveness of using the proposed system in devices for demagnetizing technical products that differ in a small indicator of the elongation of the working solenoid - primarily devices that create a uniform magnetic field with an amplitude decreasing over time of 240 A/m and are used in particular to remove soft residual magnetization from elements of space vehicles