bluuebunny/crossref_metadata_2025 huggingface dataset:
Knowledge, Attitude and Perceived barrier towards Medical Research among Undergraduates and Postgraduates Medical Students of Nepalgunj Medical College
Authors: Shrestha Merina , K.C. Rupak , Luintel Prabesh , Joshi Anjali , Mahat Rajendra
Published: January 2023

Introduction: Medical science is one of the most advance and modern technology over the course of time period with extensive research and scientific knowledge of human body and health care to make incredible changes enabling the population remain healthy with mere absence of disease or infirmity. Research is considered as one of the useful measures to track the scientific advancement of a country. Promoting research skills in undergraduate and post graduate medical students help to develop scientific advancement in medical field of a country.

Aims: To assess knowledge, attitude, and perceived barriers among undergraduate and postgraduate medical students.

Methods: An institutional based cross sectional analytical study covering total 224 undergraduate and postgraduate medical students of Nepalgunj Medical College was from January 2022 to April 2022. A pre tested, pre designed, sets of questionnaire were provided to all recruited participants after obtaining informed written consent. Then informations generated by the study were analyzed for scientific result by using descriptive analysis and independent T- test.

Results: Male students were 135(60.3%) whereas female students were 89(39.7%) only. The mean knowledge score was 33.69 ± 3.8 and mean attitude score was 19.67 ± 2.34. The average 100(44.6%) had good knowledge and 118(52.7%) had positive attitude towards medical research. Most common perceived barrier was not having proper mentoring and research familiarity. Seventy Six(39.6%) undergraduate students had behavioral hesitation to participate in research while 21(65.6%) post graduate students showed social factor as one of the hesitancy to involve in research.

Conclusion: Most of the participants had good knowledge regarding research and expressed positive attitude toward involvement in research activity. Some of barriers were lack of funds, awareness and research skills. This study would improve scientific knowledge and research skills for academicians and clinicians too.
Music as therapy in Bhim Birag’s selected songs
Authors: Shrestha Tara Lal
Published: January 2023

An art or an artist is not beyond influences of the dominant historical- politico-cultural- forces. However, an art is a platform of meditation, where an artist can remain beyond historicity and exists as a healer. Birag lived an enduring painful physical life, but he used music as a therapy. In his simple looking serious songs he exists as a therapist, and it looks as if beyond his ideological ‘I’. In search of an escape from his painful life, he engaged his moments in composing serious songs, which embody certain level of therapeutic essence. This paper presents an outcome of the qualitative research on Bhim Birag’s biography and his selected songs primarily connecting his painful life with his creative life. On the basis of interviews and discussions along with published documents, it shows evidences about how he played some eclectic roles as a therapist persona via his celebrated songs. Finally, this research tries to connect the therapeutic essence of his serious songs to historicity from the eclective approach, where his ideological ‘I’ converses with his therapist persona and his texts (songs) negotiate to the politico-cultural contexts.
An Exploratory Study on Status of Homestays from Lamjung
Authors: Ghimire Maya Nath , Neupane Dasarath
Published: January 2023

This is a preliminary assessment on the situation of homestays in Lamjung, Nepal. This study is a comparison of international, national, and local home stays in Nepal's Lamjung district. The core topic of the study was an investigation of the guest's desired and existing facilities, biodiversity (agriculture, forest, and wild life), conservation role, income, and interest in stays. In-depth interviews were used in a qualitative study. The study was carried out in three home stay locations: SAARC village home stay Ghalegaun, national home stay Kaulepani Gaunsahar, and local home stay Rainaskot in Nepal's Lamjung district. The guest desired a variety of facilities such as an attached bathroom with hot and cold water, traditional food and cultural programs and attire. There are a neat and clean atmosphere with beautiful Himalaya views. It is suggested to visit these places at least once.
Організація навчальної роботи з обдарованими учнями в початковій школі в умовах реалізації концепції нової української школи
Authors: Комогорова Марина , Здоренко Петро
Published: January 2023

Сучасний розвиток світової цивілізації характеризується швидкими темпами впровадження нових інформаційних технологій та глобалізаційними процесами. Прогрес практично всіх галузей людської діяльності залежить від людей, які нестандартно сприймають навколишній світ, надзвичайно активні, енергійні, працездатні та можуть досягати високих результатів у обраній сфері діяльності. Отже, проблема обдарованості, творчості, інтелекту виступає на перший план у державній політиці, визначаючи пошук, навчання та виховання обдарованих дітей та молоді.Проблема виявлення, розвитку та навчання обдарованих дітей викликає значний інтерес в педагогічному середовищі в умовах реалізації Концепції Нової української школи. Численні дослідження особливостей розвитку обдарованих дітей підкреслюють актуальність цієї проблеми як в нашій країні, так і за її межами. Особлива увага приділяється формуванню та розвитку творчих здібностей дітей саме з перших кроків їх навчання в початковій школі. Обдарованими називають молодших школярів, які, на думку фахівців, завдяки своїм видатним здібностям демонструють високі досягнення в одній або кількох сферах: інтелектуальній, у сфері творчого чи продуктивного мислення, організаційної, художньої, спортивної тощо. Чіткі критерії обдарованості ще не розроблено, хоча більшість фахівців погоджується з думкою, що випереджаючий розвиток притаманний обдарованим дітям, тобто випереджати своїх однолітків за рядом психічних параметрів. У пізнавальній сфері це проявляється у надзвичайній допитливості, здатності стежити за кількома процесами одночасно, активно досліджувати навколишній світ, сприймати зв’язки між явищами та робити відповідні висновки, створюючи альтернативні системи в уяві. Представлено досвід авторів щодо форм та змісту навчальної роботи з учнями з метою розкриття їх творчого потенціалу.Розбудова Нової української школи, викликана потребою пошуку відповідності сучасних потреб української освіти світовим стандартам, передбачає створення умов для забезпечення виявлення й розвитку обдарованих дітей, реалізацію їх потенційних можливостей. У Концепції «Нова українська школа» підкреслюється, що кожна дитина – неповторна, наділена від природи унікальними здібностями, талантами та можливостями, а «місія нової української школи – допомогти розкрити та розвинути здібності, таланти і можливості кожної дитини» на засадах особистісно-орієнтованої моделі освіти та принципу дитиноцентризму. Особливо важливою є роль учителя в становленні особистості обдарованої дитини молодшого шкільного віку, оскільки зовнішні впливи на учня здійснюються впродовж подальшого життя. У Професійному стандарті «Вчитель початкових класів закладу загальної середньої освіти», що став першим професійним стандартом в Україні, затвердженим на національному рівні, визначено «здатність до врахування при створенні освітнього середовища індивідуальних потреб учнів, в тому числі й обдарованих дітей» однією з провідних професійних компетентностей вчителя початкових класів.
Визначення критеріїв оцінювання сформованості іншомовної компетентності майбутніх учителів початкової школи
Authors: Попова Людмила
Published: January 2023

У статті розглядається актуальна проблема готовності до іншомовної професійної комунікації майбутніх учителів початкової школи. Особлива увага надається концептуальним засадам формування системи підготовки майбутніх фахівців, основним принципам й умовам їхнього професійного розвитку, що підтверджено низкою нормативно-правових документів. Розглянуто доробки багатьох вітчизняних та зарубіжних дослідників, які розробляли питання формування іншомовної компетентності студентів; завдання, пов’язані з визначенням цілей і змісту іншомовної освіти. Це обумовлюється створенням європейського простору вищої освіти та потребує реалізації нагальних завдань щодо посилення мотивації до вивчення студентами іноземної мови у закладах вищої освіти та більш ефективного іншомовного професійного спілкування.Визначені й досліджені критерії та рівні сформованості володіння навичками іноземної мови студентами немовних спеціальностей, подано результати «скрінінгового тестування» студентів першого курсу, відзначена важливість моделювання навчальних ситуацій як комплексного засобу стимуляції студентів до самоаналізу, самооцінки, саморозвитку, спілкування з урахуванням ролі психологічних аспектів організації навчального процесу з іноземної мови. Також в дослідженні представлені результати проведеного експерименту з впровадження технології моделювання навчальних ситуацій.Доведено, що формуванню умінь застосовувати рецептивні стратегії планування освітнього процесу слугують підготовчі інтерактивні вправи з активним використанням засобів інформаційно-комунікативних технологій, елементів інтенсивного навчання. Запропонована особистісно-орієнтована модель навчання іноземної мови з елементами інтенсиву, що поділяється на психолого-педагогічний та методичний компоненти.Особлива увага приділена психолого-педагогічним особливостям організації освітнього процесу з іноземної мови, формування мотивації вивчення іноземної мови у студентів закладів вищої освіти.
Феномен гетерогенності в умовах єдиного освітнього простору
Authors: Тутова Тетяна
Published: January 2023

Стаття присвячена визначенню сутності феномену гетерогенності в освітній площині та гетерогенності як психолого-педагогічної проблеми в контексті нової української школи. Здійснено ретельний аналіз феномену гетерогенність в філософській, психологічній, педагогічній та соціологічній літературі.Гетерогенність розглянуто як основу, що складається з різних за своєю природою або походженням феномен. Термін «гетерогенний» означає інший або відмінний, складений з неоднорідних елементів. Феномен гетерогенності в освітній площині розглядається як відмінності, які існують між людьми щодо статі, віку, соціального статусу, етнонаціональної приналежності, релігії, здоров’я або інвалідності, специфічних рис особистості тощо.Сучасне розуміння гетерогенності в освітньому просторі характеризує суб’єктів освітнього процесу на основі критеріїв: етнічна приналежність та обумовлена нею мова, національні традиції, культура, ментальність та ін.; релігійні вірування (традиційні або нетрадиційні релігійні погляди та переконання); стан здоров’я, психофізичні особливості; соціальний статус учня та його родини; інтелектуальний та творчий потенціал; соціально-емоційні характеристики; субкультурні установки та виділено в гетерогенні групи учнів, серед яких: діти мігрантів, біженців та переселенців; діти з сімей представників різних релігійних конфесій; діти з інвалідністю або діти з особливостями психофізичного розвитку; діти з сімей із різним статусом соціального неблагополуччя; діти, обдаровані в інтелектуальній та творчій сферах діяльності; діти з соціально-емоційною винятковістю, які мають труднощі в навчанні; підлітки та молодь, що належать до різної молодіжної субкультури.Дослідження феномену гетерогенності в освітній площині розширює спектр підготовки майбутніх педагогів в контексті Нової української школи, що включає, по-перше, діагностику та облік індивідуальних особливостей учнів за критеріями гетерогенності, по-друге, створення умов для розвитку цих особливостей і, по-третє, адаптацію усіх учасників освітнього процесу, незалежно від їх можливостей та взаємодії в соціумі на рівних умовах.
CONTROLE DE QUALIDADE EM UNIDADE DE BENEFICIAMENTO DE CARNE UTILIZANDO A FERRAMENTA 5S.
Authors: Martins Gabriela de Anunzio , Lemos Stella Vannucci
Published: January 2023

A qualidade tem sido uma característica importante para que as empresas permaneçam no mercado e vençam a competitividade. A pecuária tem apresentado grande relevância para a economia brasileira e esse fator certamente se deve a existência da observação de práticas que garantem o controle da qualidade. Muitas ferramentas são utilizadas atualmente pelas empresas para promover a qualidade de seus produtos e serviços, e o 5S está dentre as quais tem apresentado resultados positivos. Dentro desse contexto, o objetivo dessa pesquisa é analisar a possibilidade de implementação da ferramenta 5S para o controle de qualidade em uma unidade de beneficiamento de carne na cidade de Taquaritinga, interior do estado de São Paulo. A metodologia utilizada foi de Revisão Bibliográfica e pesquisa em campo. Os resultados mostram que a empresa foco do estudo está em análise sobre a aplicação ferramenta 5 S como forma de conseguir qualidade em todo seu processo produtivo e produto final.
IMPACTO DE UM SISTEMA ERP NA GESTÃO DE ESTOQUES
Authors: Paiva André Luiz do Nascimento , Lanzotti Carla Regina
Published: January 2023

O contexto deste estudo foi demonstrar os fatores críticos e a mudança organizacional que um sistema de gerenciamento integrado (ERP) traz para uma empresa. Por meio de uma revisão bibliográfica foram abordados os conceitos de gestão de estoques e sistemas de gerenciamento integrados, tais análises resultaram na determinação da importância em se mapear os fluxos de processos, e a partir disso, criar uma padronização da rotina com foco na solução dos problemas. A metodologia baseou-se na aplicação de uma pesquisa descritiva, tendo como objeto uma situação real no ambiente de trabalho em uma empresa do ramo alimentício. Como resultado direto, identificou-se a desburocratização dos processos, a redução significativa dos tempos operacionais e gerenciais, maior eficiência no atendimento aos clientes internos, diminuição das movimentações, assertividade nas localizações e métodos de armazenagem de acordo com a classificação dos materiais produtivos e improdutivos.
DESAFIOS DA GESTÃO DA DIVERSIDADE NAS ORGANIZAÇÕES
Authors: De Jesus Joandson Santos , Da Costa Elvio Carlos
Published: January 2023

O presente trabalho se debruça sobre a temática da gestão da diversidade e inclusão no contexto corporativo.  A diversidade está no nosso meio desde sempre, mas nos tempos atuais ganhou mais destaque e relevância, uma vez que as empresas tem obtido vantagens nas ações que promovem tal inclusão e diversidade, além de proporcionar mais engajamento as demandas da sociedade contemporânea. Nesse sentido, o objetivo desse estudo foi conhecer as vantagens que as ações de diversidade proporcionam as organizações, em relação à criatividade, à competitividade, à lucratividade e à visibilidade em um mundo tão globalizado.   Metodologicamente, foi realizado um pesquisa bibliográfica, por meio de um levantamento nas bases de dados da Scielo e Google Acadêmico. Os resultados obtidos são muito consistente, e nos fazem refletir sobre o quanto ainda precisamos evoluir, seja como empresa ou como pessoas, pois além de se destacar em relação à concorrência, verificou-se que o retorno financeiro, especialmente no que concerne a faturamento e lucratividade, são vantajosos para as estratégias organizacionais. Diante disso, pode-se afirmar que investir em diversidade traz benefícios tanto para as empresas quanto para a sociedade em geral, uma vez que o bem-estar praticado internamente nas empresas, possivelmente irá refletir no cotidiano das pessoas.
GESTÃO ESTRATÉGICA DE COMPRAS
Authors: Revoredo Daniel Donizeti , Regattieri Carlos Roberto
Published: January 2023

As mudanças de comportamentos com o Impacto da Pandemia do Covid-19 no setor sucroenergético tem sido assunto de grandes discussões, uma vez que problemas procedentes desse contexto trazem grandes desafios tanto para a economia do setor como também para as empresas em que este atua. Sendo assim a busca de métodos e estudos para se manterem no mercado e garantir sua competitividade a ferramenta Gestão Estratégica de Compras tem contribuído com resultados significativamente positivos neste setor. Este objetiva discutir e trazer informações sobre o tema proposto. A metodologia utilizada foi a revisão de literatura, onde foram consultados livros que traziam assunto o tema escolhido para este estudo de autores renomados da área. Procuramos demonstrar o cenário pandêmico no setor sucroenergético, a importância do setor de compras em épocas de crise e representatividade do volume de compras. Desta forma este trabalho resultou entender a importância da Gestão Estratégica de Compras no âmbito empresarial, que tem se tornado fundamental para a eficiência econômico-financeira do negócio em épocas de crises.
RECUPERAÇÃO DE SOLO COM O SISTEMA AGROFLORESTA
Authors: Moraes João Antonio Tonon , Cavichiolli Fábio Alexandre
Published: January 2023

Embora seja amplamente necessária há tempos a recuperação de áreas degradadas no Brasil, é uma atividade recente. Antes do surgimento e da evolução das técnicas empregadas, as atividades de recuperação do solo baseavam-se apenas no plantio de árvores. Diante de vários estudos as técnicas utilizadas atualmente consistem em amplas evoluções de programas voltados para a recuperação ambiental, que buscam adequar a biodiversidade dos ecossistemas existentes em determinadas regiões. O objetivo desse estudo foi evidenciar a recuperação do solo com o sistema de agrofloresta. A metodologia usada neste estudo é de revisão bibliográfica, com consultas realizadas em artigos on-line. Os resultados mostram que o uso de sistemas agroflorestais para a recuperação do solo tem apresentado eficiência.
ANÁLISE DE DADOS E DESEMPENHO DE JOGADORES EM GAMES UTILIZANDO API DE DADOS
Authors: De Oliveira João Vitor Lemes , Graciano Fernando Cesar
Published: January 2023

League of Legends (LOL) é um MOBA da Riot, com muitos fãs em torno do mundo. Cada jogador escolhe um personagem, com habilidades e funções específicas, tanto para defender sua base quanto atacar o adversário. O cenário competitivo de LOL vem crescendo muito em todo o mundo sendo assim existindo no total de 12 Regiões com 12 ligas de jogadores profissionais, cada região possui sua liga principal e, em outros casos, até divisões inferiores, como no Brasil. Application Programming Interface (API) É uma camada de software que fornece requisição e resposta estruturadas. Permite que um software se comunique com outro software de forma simplificada e segura. Uma API é criada para que outros criadores de software possam desenvolver produtos com semelhança no seu serviço. No mundo existe várias empresas que disponibilizam os seus códigos para uma outra empresa de software, sendo assim, por esse motivo existem grandes semelhanças em aplicativos, jogos entre outras coisas.
AUMENTO DA DISPONIBILIDADE OPERACIONAL ATRAVÉS DA APLICAÇÃO DO LEAN MANUFACTURING
Authors: De Simone Beatriz Greicyelle , Regattieri Carlos Roberto
Published: January 2023

Nos dias atuais, a competitividade é uma exigência básica para a sobrevivência e oportunidades de expansão de uma empresa, proveniente de melhorias na produtividade e redução de custos, sem afetar a qualidade dos seus produtos. Este trabalho apresenta o sistema de gestão Lean Manufacturing e a ferramenta SMED como uma alternativa para solução de um problema comum entre as empresas: o desperdício. Neste artigo, vamos demostrar a aplicação desta metodologia para reduzir o tempo de SETUP de uma linha de produção, afim de aumentar a disponibilidade operacional de uma grande e renomada empresa alimentícia por meio de uma pesquisa de campo. Os resultados obtidos  demonstram que o Lean Manufacturing é uma ferramenta poderosa para incremento na competitividade e melhorando a qualidade de trabalho dos seus colaboradores.
ANÁLISE DAS MUDANÇAS NO ESPAÇO URBANO DO DISTRITO DE GUARIROBA-TAQUARITINGA–SP, UTILIZANDO GEOTECNOLOGIA
Authors: Fincolo Daniele Amanda , Rodrigues Gilberto Aparecido , Soares Nathalia Maria
Published: January 2023

O crescimento urbano acontece normalmente do centro para as regiões suburbanas que os contornam, tornando-se um feito frequentemente contínuo de crescimento que pode também acontecer da cidade para as áreas rurais mais próximas. É considerável entender que a cidade diz respeito à área urbana interna de um município, e o campo à área rural, de forma que alguns municípios contam com uma área completamente urbana ou totalmente rural. O objetivo desse trabalho é verificar o crescimento urbano no distrito de Guariroba, município de Taquaritinga-SP, nos anos de 2003/4 e 2022. A metodologia utilizada neste estudo foi o uso de imagens de satélite, disponível no software livre Google Earth Pro (GEP). Constatou-se no período considerado alterações no uso e ocupação do solo, onde as culturas lenhosas (Gênero Citrus) foram substituídas pela cultura da cana-de-açúcar, causando alterações na paisagem rural.
IMPORTÂNCIA DA GESTÃO DE ESTOQUE EM UMA INDÚSTRIA DE PRODUTOS ALIMENTÍCIOS E O USO DO SISTEMA ERP
Authors: Garcia Hugo Felipe , Reis Filho Ramilio Ramalho
Published: January 2023

Gerenciar o estoque de uma empresa sempre foi papel de grande importância. Em tempos não muito distantes, as organizações achavam que manter estoques volumosos era sinônimo de riqueza. Com o passar dos anos, os estoques deixaram de ser acumulativos e passaram a possuir apenas o que era necessário para a produção fator essencial para a economia. Os alimentos produzidos assim como suas matérias-primas devido ao fato de serem perecíveis não podem ficar estocados por um amplo tempo, sendo assim especificamente nas indústrias de alimentos a gestão de estoque se faz extremamente importante como forma de economia e diminuição de desperdício, além de que produtos mais frescos acabam por gerar uma produção com mais qualidade e eficiência. Dentro desse contexto, o objetivo deste estudo é trazer a importância da gestão de estoque e como a mesma acontece dentro de uma indústria de produtos alimentícios. O trabalho traz revisão de literatura e pesquisa em campo em uma indústria de alimentos que vê o processo de gestão de estoque como um fator essencial para a garantia de produtividade e competitividade. A empresa utiliza como ferramenta para a gestão de estoque o Sistema ERP. Os resultados encontrados na literatura apontam a eficiência do processo de gestão de estoque e como gerenciar esse processo traz importantes benefícios.
AGROINDÚSTRIA DE QUEIJOS ARTESANAIS
Authors: Pasquini Paulo Roberto , Ferrarezi Junior Edemar
Published: January 2023

O desenvolvimento do projeto consiste na criação de um manual capaz de orientar produtores de leite, que desejem abrir uma  fábrica de queijos artesanais, desenvolver diretrizes que ajude e direcione o pequeno produtor de leite e especialmente empresas de origens familiares, cujo quais possuem poucas vacas e sua produção é ínfima e incapaz de gerar divisas em sua forma original, garantindo assim o aproveitamento do principal produto produzido em suas propriedades, agregando valor a esse produto, garantindo uma segunda renda capaz de custear as famílias mantendo-as no campo em detrimento a produção de alimentos para subsidiar outras muitas famílias que depende diariamente da oferta desse alimento cada dia mais escasso para sobreviver.
AVALIAÇÃO DE RECONHECIMENTO DE EMOÇÃO DIMENSIONAL COM UMA ABORDAGEM BASEADA EM ATENÇÃO
Authors: Ferreira Antonio José da Silva , Soares Gabriela Regina , Cardia Neto João Baptista
Published: January 2023

O feedback não verbal e o reconhecimento das expressões faciais têm sido área de muita pesquisa nas últimas décadas. As expressões faciais são uma maneira concreta de reconhecer emoções e “ensinar” os computadores a detectar corretamente o que cada expressão facial significa e a qual emoção está ligada. Assim, no âmbito do reconhecimento de imagens, as Redes Neurais Convolucionais (RNC), através de suas camadas sobre os pixels da imagem, facilitam a descoberta de padrões. Dessa forma, através da aplicação de uma RNC com um mecanismo de atenção, o objetivo do presente artigo é decodificar as expressões não verbais presentes no banco de dados utilizado e identificar a quais emoções estão ligadas. Através da análise do CCC (Coeficiente De Correlação De Concordância) e do Erro Quadrático Médio (RMSE) para as dimensões de valence e arousal, o presente artigo mostra que o método utilizado traz resultados, mas ainda é possível melhorar o aprendizado de máquina.
Microbiological assessment of sod-medium podzolic soil using various elements of biologisation
Authors: Shemetun Kateryna , Balaev A. , Tonkha Oksana , Pikovska Olena
Published: January 2023

To assess the ability of soils to self-repair and self-rehabilitation, it is important to monitor the indicators of soil microbiological activity. In conditions of manure deficiency, the restoration of organic matter of soils is provided by using non-commercial share of the crop and growing green manure crops, which is especially important for zonal soils of Ukrainian Polissia. The purpose of the study was to estimate the number of various physiological groups of microorganisms in sod-medium podzolic soil under the influence of various fertiliser systems. Field, laboratory, and statistical methods were used in the study. Field method: an experiment was conducted in a field of the Chernihiv Institute of Agricultural Microbiology and Agroindustrial Production of the NAAS with an area of sown plots of 102 m2 on sod-medium podzolic light loamy soil with a humus content of 0.9-1.1% in 0-30 cm layer. The number of different groups of microorganisms that transform carbon and nitrogen compounds was determined in soil samples. Statistical methods – system analysis, mathematical and statistical analysis. Sowing of green manure such as lupine and oilseed radish had a positive effect on the number of ammonifiers (4.3-13.2 million CFU), which is 44-180% more than in the control. The mineral fertiliser system for potatoes also increased the number of ammonifiers by 15-50% compared to the option without fertilisers. The mineralisation-immobilisation coefficient was calculated as the ratio of the number of microorganisms that immobilise mineral forms of nitrogen to the number of organotrophs, and the pedotrophicity coefficient by the ratio of the number of microorganisms on soil agar to the number of microorganisms that grew on meat-peptone agar. It was established that the cultivation of green manure on sod-podzolic soil has a positive effect on the development of physiological groups of microorganisms and the microbiological processes tend to accumulate humus. The materials of the study are of practical value for agricultural producers who are engaged in growing potatoes on sod-podzolic soils in the possibility of replacing manure and mineral fertilisers in the fertiliser system of agricultural crops with green manure (lupine, oilseed radish)
Factors Associated with Bone Scintigraphy Positivity in Cholangiocarcinoma
Authors: Siurai Nattawat , Twinprai Prin , Theerakulpisut Daris , Chindaprasirt Jarin , Raruenrom Yutapong
Published: January 2023

Objective: To examine factors associated with bone scintigraphy (BS) positivity in cases with cholangiocarcinoma (CCA) to help assess appropriate utilization of BS in CCA patients. Material and Methods: This cross-sectional study enrolled CCA patients who underwent BS for detection of bone metastasis between January 2012 and July 2020. The BS images were reviewed by two nuclear medicine physicians to assess BS positivity. Factors including tumor location, T stage, regional lymph node metastasis, other distant metastases, and serum carbohydrate antigen 19-9 (CA19-9) were evaluated. Associations between covariates and positive BS were analyzed using bivariate and multiple logistic regressions. Results: Among 158 CCA patients, 70 (44.3%), 84 (53.2%), and 4 (2.5%) had positive, negative, and equivocal BS, respectively. Of all 70 positive cases, 50 cases (71.4%) had multiple metastatic lesions. The spine was the most common metastatic site (n=55, 78.6%). After exclusion of equivocal cases, 154 were included in the regression models. In bivariate logistic regression, the factors associated with BS positivity were intrahepatic tumor location (OR=2.18, p-value=0.039) and other distant metastasis (OR=2.08, p-value=0.028). Further analysis using multiple logistic regression showed only other distant metastasis was associated with positive BS (OR=2.66, p-value=0.008). Conclusion: There was a significant association between other distant metastasis and BS positivity in CCA patients. This factor should be considered as a clinical indication for requesting BS in this group of patients.
Effect of Jujuboside A on Brain Ischemia / Reperfusion Injury Via Expression of Antiapoptotic Gene
Authors: Movassaghi Shabnam , Karimi Alieh , Eydi Akram , Sharifi Zahra Nadia
Published: January 2023

Background: Some studies highlighted the role of Jujuboside A as a potent antioxidant on ischemic neurons. However, the definitive effect of this substance on the change in the expression of the neuroprotective genes has not been clearly identified. Therefore, this study aimed to investigate the effects of Jujuboside A on the expression of proliferation-inducing genes and cell count enhancement in the hippocampus after the induction of transient global ischemia/reperfusion. Materials and Methods: This experimental study was performed on 24 male Wistar rats in four groups control, ischemia, vehicle, and Jujuboside A. Three days after induction of ischemia, the hippocampus of animals was removed and isolated from brain tissue. In order to investigate the results of the intervention, the expression of nuclear factor-ÎºB (NF-ÎºB), nerve growth factor (NGF), and Brain-derived neurotrophic factor (BDNF) genes were determined using real-time polymerase chain reaction. Results: The results showed that NGF expression was significantly higher in the Jujuboside A group than in the ischemic group (P<0.05). Moreover, the expression of BDNF in the Jujuboside A group was increased compared to the ischemic group. However, the expression of NFÎºB in the Jujuboside A group was lower than that of the ischemic and control groups, but these changes were not significant (P>0.05). Conclusion: Jujuboside A can increase the expression of NGF by promoting a protective effect on the hippocampus after transient global ischemia/reperfusion.
Dietary Quality Indices and Its Cardiovascular Diseases Risk Factors: A Survey from the Kavar Cohort Study
Authors: Dehzad Mohammad Jafar , Safarpour Ali Reza , Hejazi Najmeh , Moghdani Zahra
Published: January 2023

Background: Atherosclerosis is known to be a significant reason for cardiovascular diseases (CVDs). Hypertension, dyslipidemia, diabetes, obesity, smoking, physical inactivity, and unhealthy diet are the most important causes of atherosclerosis. This study aimed to determine the relationship between DASH Diet Index, Dietary Inflammatory Index (DII), Mediterranean Diet (MEDI-LITE) Index, and CVDs risk factors. Materials and Methods: Out of 4997 patients, all eligible patients with CVDs (n=264) were chosen as the patient group, and 264 healthy individuals were included in the healthy group. Dietary intake and anthropometric measures were evaluated, including height, weight, hip and waist circumference, blood pressure, and lipid profile. Results: Among the three dietary indices, the DASH diet score was significantly higher in the healthy group than in the patient group (P=0.02). An inverse relationship was found between the DASH Diet Index and waist-to-hip ratio (r=-0.33, P=0.042), Visceral Adiposity Index (VAI; r=-0.16, P=0.044), systolic blood pressure (r=-0.13, P=0.035), triglycerides (r=-0.36, P=0.046), total cholesterol (r=-0.47, P=0.02), and low-density lipoprotein-C (LDL-C) levels (r=-0.09, P=0.03) in the patient group. Additionally, the MEDI-LITE Index was inversely associated with body mass index (BMI; r=-0.12, P=0.04), waist circumference (r=-0.065, P=0.05), triglyceride (r=-0.25, P=0.015), total cholesterol (r=-0.4, P=0.02), LDL-C levels (r=-0.2, P=0.006), and systolic blood pressure (r=-0.122, P=0.005) in the patient group. Also, a significant positive relationship was observed between the DII and BMI in both patients and healthy individuals (r=0.76, P=0.006 vs. r=0.24, P=0.01, respectively) and hip circumference (r=0.638, P=0.035) in the patients group. However, no significant relationship was observed between DII and CVDs risk factors. Conclusion: Patients with higher DASH diet scores had lower waist-to-hip ratio, VAI, total cholesterol, LDL-C, triglycerides, and lower blood pressure. In addition, patients with higher MEDI-LITE scores had lower BMI, waist circumference, triglycerides, total cholesterol, LDL-C, and lower blood pressure, but no correlation was found the healthy group.
Safety of Electro-Convulsive Therapy in Combination with Duloxetine in Treatment-resistant Depressive Patients: A Randomized Clinical Trial
Authors: Fakhraei Bahareh , Farjam Mojtaba , Moghimi Sarani Ebrahim , Samimi Nastaran , Hedayati Arvin , Jaafari Nematollah
Published: January 2023

Background: There are several strategies in the management of treatment-resistant depression (TRD), including the administration of other antidepressants, augmentation therapy, electro-convulsive therapy (ECT), and a combination of ECT and antidepressants. The safety of ECT combined with any medication must be confirmed. The aim of this study was to assess the safety of duloxetine and ECT combination therapy. Materials and Methods: In this randomized clinical trial, the probable side effects of ECT plus duloxetine were compared with ECT plus sertraline in two groups of admitted TRD patients. Patients with general medical diseases and/or any contraindications to ECT or any of the two drugs were excluded. General side effects, including nausea, vomiting, and headache reported by patients (hours after ECT) as well as cardiotoxicity by electrocardiogram (immediately after any ECT episode), cognitive status by mini-mental state examination (MMSE, one month after the last ECT), and seizure duration were recorded for each patient. Results: No significant differences were observed in nausea, vomiting, headache, and myalgia between ECT+duloxetine and ECT+sertraline groups. Heart rate, QTc interval, ST-T change, and the incidence of arrhythmia were the same between the two arms of the study. Also, no prolonged seizures and status epilepticus were recorded among the studied patients. The MMSE revealed no marked differences in the cognitive status among patients of the two groups. Conclusion: ECT+duloxetine and ECT+sertraline were equally safe in patients with TRD.
The Role of the Ultrasonographic Knee Assessment in the Diagnosis of Patellofemoral Pain Syndrome
Authors: Ghasemi Nasim , Haghighat Shila , Karami Mehdi , Vahdatpour Babak , Soleimany Samira
Published: January 2023

Background: Patellofemoral Pain Syndrome (PFPS) is a common anterior knee compartment pain etiology. It has been aimed to assess the ultrasonographic findings of the patellofemoral joint in patients with PFPS versus healthy individuals. Materials and Methods: The current case-control investigation was performed on 30 cases suffering from patellofemoral joint pain and 30 healthy individuals in Isfahan during 2020-21. All cases underwent ultrasonography to assess cartilage thickness, sulcus angle, and sulcus depth. We also measured the Q angle with a manual goniometer. Results: In healthy individuals, Q angle scores were statistically lower than in the cases group (P=0.002). The sulcus angle was remarkably higher among the patients compared to the controls. The cartilage thickness (P=0.88) and sulcus depth (P=0.543) scores had no statistical difference between the PFPS and healthy subjects (P<0.05). Conclusions: Patients with PFPS had significantly higher Q angle and lower sulcus angle than the healthy controls.
Evaluation the Possible Role of Interleukin-6 and Tumor Necrosis Factor- Alpha in Pathogenesis of Obstructive Sleep Apnea in Obese Patients: A Case-Control Study
Authors: Minaeian Sara , Rahmani Fard Soheil , Ahsant Samaneh , Riahi Taghi , Taheri Tinjani Reyhaneh , Alimohamadi Yousef , Kooranifar Siavash , Shamlou Mahmoudi Fatemeh , Hosseinipour Ali
Published: January 2023

Background: According to a mounting body of evidence, recent observations have highlighted considerable association between obstructive sleep apnea (OSA) syndrome and patientsâ€™ obesity and inflammation, however the exact underlying mechanisms remain to be fully understood. In this study, the relationship between OSA and Interleukin-6 and Tumor necrosis factor- alpha was assessed in obese patients and their serum concentrations were compared to non-OSA obese subjects. Materials and Methods: This case-control study was conducted on forty-six obese OSA patients (body mass indices, BMI>30) and 42 obese but otherwise healthy individuals who were admitted to the pulmonary or obesity clinics of the Hazrat-e Rasool General Hospital (Tehran, Iran) between November 2019 and May 2020 were included. The participants completed the NOSAS, EPWORTH and STOPBANG questionnaires. Tumor Necrosis Factor-Alpha (TNF-Î±) and Interleukin-6 (IL-6) serum concentrations were determined using the enzyme-linked immunosorbent assay (ELISA) method. Results: Compared to the non-OSA group, OSA patients had higher systolic and diastolic blood pressure, pCO2, bicarbonate (HCO3) and hemoglobin and lower high-density lipoprotein (HDL) values. IL-6 and TNF-Î± serum levels were not significantly different between both groups. Univariate and multivariate linear regression models showed that BMI, systolic blood pressure, pCO2 and HCO3 can positively affect the serum TNF-Î± and systolic blood pressure and HCO3 can also positively affect the serum IL-6 values in patients with the OSA. Conclusion: This investigation suggests that among the OSA patients, the heightened inflammatory profile may be influenced by the high BMI. Furthermore, the exclusive relationship between different disease biomarkers and inflammatory agents in OSA patients is intriguing and needs further research.
Selection of MicroRNAs Associated between Neural Stem Cells and Multiple Sclerosis
Authors: Taleahmad Sara , Mandegarfard Sepideh , Moradi Ali , Bereimipour Ahmad , Hoseinian Mohammad
Published: January 2023

Background: Diagnosis and treatment of multiple sclerosis (MS) in its advanced state have been one of the medical community's concerns so far. Cell therapy has been a modern and successful treatment. However, it has not yet been effective enough to treat MS. This study aimed to find the relationship between neural stem cells (NSCs) and MS, and by considering important signaling pathways of pathogenesis, the most important microRNAs (miRNAs) for its diagnosis and treatment were investigated. Materials and Methods: Using the bioinformatics approaches and appropriate databases, the relationship between NSCs and MS were recognized, and after obtaining common genes between them, the protein products by them were evaluated. Finally, after nominating essential genes, we isolated and analyzed the microarrays involved in these pathways. Results: In the first step, 76 upregulated and 1600 down-regulated common genes between NSCs and MS were recognized. Upregulated genes obtained axon guidance, NCAM, and RHO signaling pathways, and the cell cycle, RNA metabolism, and DNA repair signaling pathways by down-regulated genes. Then, high-expression PAK3, ROBO2, and LIMK2, and low-expression AURKA, BIRC5, BLM, and BRCA1 proteins were identified. Accordingly, high-expression miRNAs included hsa-miR-4790-5p, hsa-miR-4281, and hsa-miR-4327, but low-expression miRNAs included hsa-miR-103b, hsa-miR-638, and hsa-miR-4537 were recognized. Conclusion: Our study indicated that the abovementioned important miRNAs have a major role in diagnosing and treating MS.
Compared Dexmedetomidine and Fentanyl on Sensory-Motor Block in Unilateral Intrathecal Anesthesia of Lower-limbs Orthopedic Surgeries: A Randomized Duble-blind Trials
Authors: Shahroudi Atefeh , Alipour Mohammad , Purafzali Firouzabadi Seyed Javad , Najaf Najafi Mona , Molaei Ehsan
Published: January 2023

Background: One of the alternatives for lower-limb orthopedic surgery is spinal anesthesia. It can affect the hemodynamic status and cause the prolonged motor and sensory blocks, as well as urinary retention, which are less common in the unilateral technique. Different drugs are used to improve the quality of the block and reduce its complications. Dexmedetomidine, a selective alpha-2 adrenergic receptor agonist, and fentanyl, an opioid medication, could administration as an adjuvant to increase the intrathecal block quality. Hence, this study aimed to compare unilateral spinal anesthesia with bupivacaine/dexmedetomidine (BD) and bupivacaine/fentanyl (BF) regimes on the sensory-motor block among patients with lower-limb orthopedic surgeries. Materials and Method: This randomized, double-blind clinical trial was performed on 36 patients who underwent lower-limb orthopedic surgeries in Qaem Hospital, Mashhad, Iran. The patients were randomly divided into two groups. Patients who received 5.7 mg hyperbaric bupivacaine 0.5% plus 10 Âµg fentanyl (BF group) or 5 Âµg dexmedetomidine (BD group) were administered for inducing unilateral spinal anesthesia. Patients and investigators responsible for data collection were not awarded from allocation groups. The sensory-motor block level, duration, postoperative analgesia, and complications were recorded and compared between the two groups. Results: No significant difference was observed between the two groups in hemodynamic changes (i.e., systolic and diastolic blood pressure and heart rate) before and after the blockage (PËƒ0.05). Also, there was no difference in the sensory-motor block level and anesthesia-related complications between BF and BD groups (PËƒ0.05). Conclusion: In patients for whom the use of opioids for unilateral spinal anesthesia is contraindicated, dexmedetomidine could be considered an appropriate alternative.
Mortality Rate and Related Risk Factors in Hospitalized Coronavirus Disease 2019 Patients with Diabetes: A Single-Center Study
Authors: Aryan Hoda , Najmaldin Atousa , Gohari Ali
Published: January 2023

Background: The outbreak of the new coronavirus disease 2019 (COVID-19) is majorly threatening the health of people worldwide. Since patients with chronic diseases, including diabetes mellitus (DM), are among the main groups at risk of severe COVID-19; hence, this study was aimed to investigate the mortality rate of COVID-19 among patients with DM. Materials and Methods: This cross-sectional study was performed on 211 DM patients with COVID-19 who were referred to Educational Kowsar Hospital in Semnan, Iran. After a definitive diagnosis of COVID-19, basic characteristics, including gender, weight, height, and clinical information (such as initial signs and symptoms, underlying diseases, complications during hospitalization, and type of treatment received) were collected. Results: The mean age of patients was 64.92Â±12.7 years, and 51.7% were male. Totally 20.9% of patients were expired. The most frequent underlying diseases were hypertension and ischemic heart disease. The simultaneous presence of cardiovascular diseases in DM patients with COVID-19 was correlated with a considerable mortality rate increment. Cough on arrival significantly predicted mortality reduction to less than one-third (P=0.009). Also, oxygen saturation of less than 90% on arrival was a significant predictor of an increase in mortality by more than double (P<0.001). Conclusion: According to the results of multivariate logistic regression, it was found that DM can increment the probability of contracting COVID-19, and the rate of mortality was also higher in these patients.
SARS-CoV-2 RNA in Follicular Fluid, Granulosa Cells, and Oocytes of COVID-19 Infected Women Applying for Assisted Reproductive Technology
Authors: Namavar Jahromi Bahia , Vakili Sina , Savardashtaki Amir , Parsanezhad Mohammad Ebrahim , Mosallanezhad Zahra , Foruhari Sedigheh , Sabetian Soudabe , Davari Zanjani Maryam , Banaei Mahnaz , Pirbonyeh Neda
Published: January 2023

Background: The Coronavirus disease 2019 (COVID-19) pandemic has raised concerns regarding the application of assisted reproductive technology (ART) in the world. Many ART programs have been delayed or continued with new precautions due to the ambiguity about vertical transmission and pregnancy safety. Regarding the possible risks of SARS-CoV-2 infection on ART and the resultant embryos, this study aimed to investigate the presence of SARS-CoV-2 in follicular fluid, granulosa cells, and oocytes of COVID-19-infected women undergoing ART. Materials and Methods: COVID-19-positive polymerase chain reaction tests were reported for five women undergoing ART cycles on the day of oocyte retrieval. SARS-CoV-2 tests were performed on oocytes, granulosa cells, and follicular fluid obtained from these COVID-19-infected women. Results: SARS-CoV-2 RNA was detected only in one follicular fluid sample; however, other follicular fluid samples, granulosa cells, and oocytes were negative regarding viral RNA. Conclusion: Given the unknown effects of COVID-19 on human reproduction and ART, strict precautions should be taken during the COVID-19 pandemic.
Multiple sclerosis impact on pregnancy: An update on management issues
Authors: Jafarinia Morteza , Badali Ahmadreza , GhorbaniNia Rahil , Mohammadian Shima , Poudineh Sahar , Sarlak Alireza , Eghbali Mohammadreza , Behzadi Esmaeil
Published: January 2023

Women with multiple sclerosis (MS) of reproductive age are becoming pregnant at an alarmingly high rate. Disease control is required during the preconception, prenatal, and postpartum periods to reduce the likelihood of relapses of MS while minimizing hazards to the mother and fetus. It has long been understood that the disease activity of MS noticeably decreases in the third trimester of pregnancy, then noticeably increases in the first three months after delivery before returning to its pre-pregnancy baseline. Relapse during pregnancy and high rates of relapse before becoming pregnant have both been linked to an increased risk of postpartum attacks. In patients with relapse MS, recent results continue to support the notion that pregnancy does not affect long-term disease progression (and may even have the opposite effect); the situation is less clear for patients with progressive MS. It is comforting to know that none of the MS disease-modifying medications have been shown to cause teratogenic consequences. This review discusses the effects of pregnancy on disease activity and how to handle relapses when pregnant and breastfeeding.