bluuebunny/crossref_metadata_2025 huggingface dataset:
TiO2 Modification with Transition Metallic Species (Cr, Co, Ni, and Cu) for Photocatalytic Abatement of Acetic Acid in Liquid Phase and Propene in Gas Phase
Authors: Amorós-Pérez Ana , Cano-Casanova Laura , Castillo-Deltell Ana , Lillo-Ródenas María Ángeles , Román-Martínez María del Carmen
Published: December 2018

The commercial P25 titania has been modified with transition metallic species (Cr, Co, Ni, and Cu), added by impregnation with aqueous solutions of the corresponding nitrates. The preparation procedure also includes a heat treatment (500 °C) in argon to decompose the nitrates, remove impurities and to strengthen the metal–TiO2 interaction. The catalysts have been thoroughly characterized using N2 adsorption, scanning electron microscopy (SEM), X-ray diffraction (XRD), UV-visible diffuse-reflectance spectroscopy (UV-vis DRS) and X-ray photoelectron spectroscopy (XPS), and have been tested in the aqueous phase decomposition of acetic acid and in the gas phase oxidation of propene, using an irradiation source of 365 nm in both cases. The photocatalytic activity of the four metal-containing catalysts varies with the nature of the metallic species and follows a similar trend in the two tested reactions. The effect of the nature of the added metallic species is mainly based on the electrochemical properties of the supported species, being Cu/P25 (the sample that contains copper) the best performing catalyst. In the photodecomposition of acetic acid, all the metal-containing samples are more active than bare P25, while in the gas phase oxidation of propene, bare P25 is more active. This has been explained considering that the rate-determining steps are different in gas and liquid media.
Space Charge Characteristics of Polypropylene Modified by Rare Earth Nucleating Agent for β Crystallization
Authors: Yang Jiaming , Gao Mingze , Zhao Hong , Liu Shilin , Hu Ming , Xie Shuhong
Published: December 2018

Compared to cross-linked polyethylene, polypropylene has a thermoplastic property and the advantage of recycling. However, the poor impact resistance at low temperature and the corresponding space charge problem restrict the application of polypropylene with the extruded high voltage direct current (HVDC) cable. Sufficient introduction of the β form of the polypropylene crystal can significantly improve impact resistance at low temperatures. Although it has been widely applied in insulation engineering, the effect of β-crystal on the space charge characteristics of polypropylene has rarely been researched until now. In this paper, a rare earth nucleating agent of β-crystal is employed to modify the performance of polypropylene to investigate the effects of nucleating agent content on β-crystalline, mechanical relaxation, trap, and space charge characteristics of polypropylene. The results of differential scanning calorimeter (DSC) and X-ray diffraction (XRD) tests indicate that the relative content of β-crystal in modified polypropylene increases gradually with the increasing concentration of the nucleating agent, approaching 43.5% when the nucleating agent content has been raised to 0.2 wt %, suggesting appreciable efficiency of the nucleating agent utilized in our research. Scanning electron microscopy (SEM) is utilized to characterize the morphology of β-crystal spherulites, which illustrates that the β-spherulites are in bunchy shape, and the lamellar crystals are parallel to each other without an obvious boundary between them. The results of the space charge test demonstrate that the modified polypropylene can substantially suppress space charge accumulation, which is attributed to an increment of β-crystal content by adopting a rare earth nucleating agent. It is indicated from dynamic mechanical analysis (DMA) measurements that the enhancement of β-crystalline in modified polypropylene can distinctly increase and decrease the β and α relaxation losses, respectively, which proves that the defects in β-crystal and amorphous regions are reduced and increased respectively. Thermally stimulated depolarization current tests further confirm that the number of traps caused by defects in the β-form of polypropylene crystal declines definitely, which dominantly accounts for the suppression of space charge accumulation.
Behavior of Wear Debris and Its Action Mechanism on the Tribological Properties of Medium-Carbon Steel with Magnetic Field
Authors: Shi Hongxin , Du Sanming , Sun Chao , Song Chenfei , Yang Zhenghai , Zhang Yongzhen
Published: December 2018

Friction tests were conducted on self-matched pairs of medium-carbon steel using a pin-disk tribometer in an ambient laboratory environment with and without wear-debris removal, in order to clarify the influence of wear debris on the tribological properties of steels that were exposed to magnetic fields. The wear debris and worn surface were observed and analyzed. In the case that the wear debris was removed, the vast majority of wear debris was large, scarce oxidation, and no agglomeration, the grooves of various shapes and discontinuities, and no oxide layer were formed on the worn surface, severe wear occurred throughout the friction process. When the wear debris was not removed, the wear debris became fine, agglomeration and oxidation, a debris layer was formed on the worn surface, and the wear mode transitioned from severe to mild occurred during friction process. The results reveal that the re-entering of wear debris into the friction area is essential for the formation of a wear-debris layer and that an anti-wear effect can be achieved via the wear-debris layer formed on the worn surface during the friction process with a magnetic field.
The Effect of Different Compatibilizers on the Properties of a Post-Industrial PC/PET Blend
Authors: Dal Lago Eleonora , Boaretti Carlo , Piovesan Francesca , Roso Martina , Lorenzetti Alessandra , Modesti Michele
Published: December 2018

The substitution of virgin resins by recycled ones is a worldwide tendency that is supported by the fluctuation of oil prices and the transition to a circular economy. Polymeric blends have been intensively studied because of their ability to provide tailored properties for particular applications. However, in their design phases, the issue of end-life re-use had not been well addressed, and now difficulties in their recycling are arising. In this study, we investigated the effect of three different compatibilizers: two chain extenders (CEs), (1) a styrene-acrylic oligomer (ESAo), and (2) methylene diphenyl diisocyanate (MDI) and an impact strength modifier, (3) an ethylene copolymer (EMAco), for the recycle of a post-industrial polycarbonate/polyethylene terephthalate (PC/PET) blend. The materials were prepared by reactive extrusion and characterized by intrinsic viscosity (IV) measurements, mechanical tests, differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy analysis (FTIR), and transmission electron microscopy (TEM). The introduction of each additive has been demonstrated to improve the compatibility between PET and PC in the post-industrial blend, leading to enhanced mechanical properties. The IV measurements increased to values that were comparable to the virgin material. In addition, CEs affected the crystallization of PET (as they reduced the degree of crystallinity), while EMAco acted as a nucleating agent. Morphological analysis enabled confirming the compatibilization effects induced by the tested additives.
Cournot-Bayesian General Equilibrium: A Radon Measure Approach
Authors: Carfì David , Donato Alessia
Published: December 2018

In this paper, we consider a Cournot duopoly, in which any firm does not know the marginal costs of production of the other player, as a Bayesian game. In our game, the marginal costs depend on two infinite continuous sets of states of the world. We shall study, before the general case, an intermediate case in which only one player, the second one, shows infinitely many types. Then, we shall generalize to the case in which both players show infinitely many types depending on the marginal costs, where the marginal costs are given by the nature and each actual marginal cost is known only by the respective player. We find, in both cases, the general Nash equilibrium.
Robust Approximate Optimality Conditions for Uncertain Nonsmooth Optimization with Infinite Number of Constraints
Authors: Sun Xiangkai , Fu Hongyong , Zeng Jing
Published: December 2018

This paper deals with robust quasi approximate optimal solutions for a nonsmooth semi-infinite optimization problems with uncertainty data. By virtue of the epigraphs of the conjugates of the constraint functions, we first introduce a robust type closed convex constraint qualification. Then, by using the robust type closed convex constraint qualification and robust optimization technique, we obtain some necessary and sufficient optimality conditions for robust quasi approximate optimal solution and exact optimal solution of this nonsmooth uncertain semi-infinite optimization problem. Moreover, the obtained results in this paper are applied to a nonsmooth uncertain optimization problem with cone constraints.
Imperfect Multi-Stage Lean Manufacturing System with Rework under Fuzzy Demand
Authors: Tayyab Muhammad , Sarkar Biswajit , Yahya Bernardo Nugroho
Published: December 2018

Market conditions fluctuate abruptly in today’s competitive environment and leads to imprecise demand information. In particular, market demand data for freshly launched products is highly uncertain. Further, most of the products are generally manufactured through complex multi-stage production systems that may produce defective items once they enter the out-of-control state. Production management of a multi-stage production system in these circumstances requires robust production model to reduce system costs. In this context, this paper introduces an imperfect multi-stage production model with the consideration of defective proportion in the production process and uncertain product demand. Fuzzy theory is applied to handle the uncertainty in demand information and the center of gravity approach is utilized to defuzzify the objective function. This defuzzified cost objective is solved through the analytical optimization technique and closed form solution of optimal lot size and minimum cost function are obtained. Model analysis verifies that it has successfully achieved global optimal results. Numerical experiment comprising of three examples is conducted and optimal results are analyzed through sensitivity analysis. Results demonstrate that larger lot sizes are profitable as the system moves towards a higher number of stages. Sensitivity analysis indicates that the processing cost is the most influencing factor on the system cost function.
Voltage-Tunable Mid- and Long-Wavelength Dual-Band Infrared Photodetector Based on Hybrid Self-Assembled and Sub-Monolayer Quantum Dots
Authors: Zhai Yao , Gu Guiru , Lu Xuejun
Published: December 2018

In this paper, we report a mid-wave infrared (MWIR) and long-wave infrared (LWIR) dual-band photodetector capable of voltage-controllable detection band selection. The voltage-tunable dual-band photodetector is based on the multiple stacks of sub-monolayer (SML) quantum dots (QDs) and self-assembled QDs. By changing the photodetector bias voltages, one can set the detection band to be MWIR, or LWIR or both with high photodetectivity and low crosstalk between the bands.
Coordinative Motion-Based Bilateral Rehabilitation Training System with Exoskeleton and Haptic Devices for Biomedical Application
Authors: Zhang Songyuan , Fu Qiang , Guo Shuxiang , Fu Yili
Published: December 2018

According to the neuro-rehabilitation theory, compared with unilateral training, bilateral training is proven to be an effective method for hemiparesis, which affects the most part of stroke patients. In this study, a novel bilateral rehabilitation training system, which incorporates a lightweight exoskeleton device worn on the affected limb; a haptic device (Phantom Premium), which is used for generating a desired tactile feedback for the affected limb; and a VR (virtual reality) graphic interface, has been developed. The use of VR technology during rehabilitation can provide goal directed tasks with rewards and motivate the patient to undertake extended rehabilitation. This paper is mainly focused on elbow joint training, and other independent joints can be trained by easily changing the VR training interface. The haptic device is adopted to enable patients to use their own decision making abilities with a tactical feedback. Integrated with a VR-based graphic interface, the goal-oriented task can help to gradually recovery their motor function with a coordinative motion between two limbs. In particular, the proposed system can accelerate neural plasticity and motor recovery in those patients with little muscle strength by using the exoskeleton device. The exoskeleton device can provide from relatively high joint impedance to near-zero impedance, and can provide a partial assist as the patient requires.
Microfluidic Long-Term Gradient Generator with Axon Separation Prototyped by 185 nm Diffused Light Photolithography of SU-8 Photoresist
Authors: Futai Nobuyuki , Tamura Makoto , Ogawa Tomohisa , Tanaka Masato
Published: December 2018

We have developed a cast microfluidic chip for concentration gradient generation that contains a thin (~5 µm2 cross-sectional area) microchannel. The diffusion of diffused 185 nm ultraviolet (UV) light from an inexpensive low-pressure mercury lamp exposed a layer of the SU-8 photoresist from the backside and successfully patterned durable 2 µm-high microchannel mold features with smooth bell-shaped sidewalls. The thin channel had appropriate flow resistance and simultaneously satisfied both the rapid introduction of test substance and long-term maintenance of gradients. The average height and width at the half height of the channel, defined by a 2 µm-wide line mask pattern, were 2.00 ± 0.19 µm, and 2.14 ± 0.89 µm, respectively. We were able to maintain the concentration gradient of Alexa Fluor 488 fluorescent dye inside or at the exit of the thin microchannel in an H-shaped microfluidic configuration for at least 48 h. We also demonstrated the cultivation of chick embryo dorsal root ganglion neuronal cells for 96 h, and the directional elongation of axons under a nerve growth factor concentration gradient.
Rutile from Panasqueira (Central Portugal): An Excellent Pathfinder for Wolframite Deposition
Authors: Carocci Eleonora , Marignac Christian , Cathelineau Michel , Truche Laurent , Lecomte Andreï , Pinto Filipe
Published: December 2018

Abundant W-rich rutile in the tourmalinized wall-rocks from the Panasqueira W-deposit appears to be a marker of the onset of the main wolframite depositing event. Rutile displays spectacular zoning, both sector (SZ) and oscillatory (OZ). An extensive set of compositional data obtained on crystals, beforehand studied using back-scattered electron images and X-ray maps, was used to address (i) the effects of SZ on differential trapping of minor elements, and (ii) the significance of the OZ in deciphering fluid sources and fluid circulation dynamics. Particular attention was paid to Sn, W (Nb, Ta) concentrations in rutile as pathfinders of the W deposition. Concerning the sector zoning, W is more incorporated than (Nb, Ta) onto more efficient faces, whereas Sn contents are nearly not impacted. The net effect of the sector zoning is thus a progressive increase of the relative weight of Sn from pyramid to prism faces, in combination with a less significant increase in the relative weight of Nb + Ta. The oscillatory zoning concerns most minor elements: W, Nb (Ta), Fe, V, Cr and Sn. In the frequent doublets, the clear bands are in general enriched in W relatively to the dark ones, whereas the inverse is true for Nb and Ta. The doublets may be viewed as the result of the successive influx of (i) a W-rich, Nb + Ta poor fluid, abruptly replaced by (or mixed to) (ii) a Nb + Ta-rich and W-poor fluid. The Nb + Ta-rich fluid could be in turn related to a rare-metal granite layer observed atop of the Panasqueira granite.
Evaluation of Polyvinyl Alcohol/Pectin-Based Hydrogel Disks as Extraction Phase for Determination of Steroidal Hormones in Aqueous Samples by GC-MS/MS
Authors: M. F. M. Sampaio Naiara , D. B. Castilhos Natara , C. da Silva Bruno , C. Riegel-Vidotti Izabel , J. G. Silva Bruno
Published: December 2018

A new extraction phase based on hydrogel disks of polyvinyl alcohol (PVOH) and pectin was proposed, characterized and evaluated for the extraction of six steroidal hormones (estriol, estrone, 17β-estradiol, 17α-ethinylestradiol, progesterone, and testosterone) in aqueous samples with subsequent determination by gas chromatography-tandem mass spectrometry (GC-MS/MS) after the derivatization procedure. The developed extraction procedure was based on the solid phase extraction (SPE) technique, but employed hydrogel as the sorbent phase. The effects of several parameters, including the amount and composition of the sorbent phase, pH, sample volume, flow rate, and gel swelling over the extraction efficiency, were evaluated. Gels with lower swelling indexes and larger amounts of sorbent ensured higher extraction yields of analytes. The main benefits of using the PVOH/pectin-based hydrogel as the extraction phase are the ease of synthesis, low-cost preparation, and the possibility of reusing the extraction disks. Limits of quantification of 0.5 μg L−1 for estrone and 17β-estradiol, and 1 μg L−1 for testosterone, 17α-ethinylestradiol, progesterone, and estriol were obtained. Accuracy values ranged from 80% to 110%, while the inter-assay precision ranged from 0.23% to 22.2% and the intra-assay from 0.55% to 12.3%. Since the sorbent phase has an amphiphilic character, the use of hydrogels is promising for the extraction of medium-to-high polarity compounds.
Less Exploited GPCRs in Precision Medicine: Targets for Molecular Imaging and Theranostics
Authors: Franco Machado João , Silva Rúben D. , Melo Rita , G. Correia João D.
Published: December 2018

Precision medicine relies on individually tailored therapeutic intervention taking into account individual variability. It is strongly dependent on the availability of target-specific drugs and/or imaging agents that recognize molecular targets and patient-specific disease mechanisms. The most sensitive molecular imaging modalities, Single Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET), rely on the interaction between an imaging radioprobe and a target. Moreover, the use of target-specific molecular tools for both diagnostics and therapy, theranostic agents, represent an established methodology in nuclear medicine that is assuming an increasingly important role in precision medicine. The design of innovative imaging and/or theranostic agents is key for further accomplishments in the field. G-protein-coupled receptors (GPCRs), apart from being highly relevant drug targets, have also been largely exploited as molecular targets for non-invasive imaging and/or systemic radiotherapy of various diseases. Herein, we will discuss recent efforts towards the development of innovative imaging and/or theranostic agents targeting selected emergent GPCRs, namely the Frizzled receptor (FZD), Ghrelin receptor (GHSR-1a), G protein-coupled estrogen receptor (GPER), and Sphingosine-1-phosphate receptor (S1PR). The pharmacological and clinical relevance will be highlighted, giving particular attention to the studies on the synthesis and characterization of targeted molecular imaging agents, biological evaluation, and potential clinical applications in oncology and non-oncology diseases. Whenever relevant, supporting computational studies will be also discussed.
Fatty Acids-Based Quality Index to Differentiate Worldwide Commercial Pistachio Cultivars
Authors: Esteki Mahnaz , Ahmadi Parvin , Vander Heyden Yvan , Simal-Gandara Jesus
Published: December 2018

The fatty acid profiles of five main commercial pistachio cultivars, including Ahmad-Aghaei, Akbari, Chrok, Kalle-Ghouchi, and Ohadi, were determined by gas chromatography: palmitic (C16:0), palmitoleic (C16:1), stearic (C18:0), oleic (C18:1), linoleic (C18:2), linolenic (C18:3), arachidic (C20:0), and gondoic (C20:1) acid. Based on the oleic to linoleic acid (O/L) ratio, a quality index was determined for these five cultivars: Ohadi (2.40) < Ahmad-Aghaei (2.60) < Kale-Ghouchi (2.94) < Chrok (3.05) < Akbari (3.66). Principal component analysis (PCA) of the fatty acid data yielded three significant PCs, which together account for 80.0% of the total variance in the dataset. A linear discriminant analysis (LDA) model that was evaluated with cross-validation correctly classified almost all of the samples: the average percent accuracy for the prediction set was 98.0%. The high predictive power for the prediction set shows the ability to indicate the cultivar of an unknown sample based on its fatty acid chromatographic fingerprint.
Optimization of the Steam Explosion Pretreatment Effect on Total Flavonoids Content and Antioxidative Activity of Seabuckthom Pomace by Response Surface Methodology
Authors: Tu Jianqiu , Liu Huiping , Sun Naxin , Liu Shaojuan , Chen Pei
Published: December 2018

Steam explosion pretreatment was conducted on seabuckthom pomace. Response surface methodology was used to optimize the treatment conditions of steam explosion, including steam pressure, duration and particle size. After this, the content of total flavonoids and the antioxidant capacity of total flavonoids were investigated. Results showed that when the steam pressure was 2.0 MPa, duration was 88 s and a sieving mesh size was 60, the total flavonoids content in seabuckthorm reached a maximum of 24.74 ± 0.71 mg CAE/g, an increase of 246% compared with that without steam explosion treatment (7.14 ± 0.42 mg CAE/g). Also, DPPH and ·OH free radical scavenging ability showed significant improvement, with an IC50 decrease to 13.53 μg/mL and 4.32 μg/mL, respectively, far lower than that in original samples. Through the scanning electron microscope, the surface of seabuckthom pomace after steam explosion was crinkled, curly, and holey. Our study showed that the content of total flavonoids in seabuckthom pomace could be obviously promoted and the antioxidant capacity of total flavonoids also improved significantly, after applying steam explosion pretreatment to seabuckthom pomace, making this approach meaningful for the reuse of seabuckthom pomace resources.
Synthesis of Highly Concentrated Suspensions of Silver Nanoparticles by Two Versions of the Chemical Reduction Method
Authors: Gakiya-Teruya Miguel , Palomino-Marcelo Luis , Rodriguez-Reyes Juan Carlos F.
Published: December 2018

In spite of the widespread use of the chemical reduction method to obtain silver nanoparticles, the nanoparticle yield is often low due to a required addition of small volumes of diluted metal ions to a solution containing a reducer. Higher yields can be obtained following an alternative method, in which the reducer is added to a greater volume of silver ions in the solution. In this study, protocols for both methods are detailed and compared, using characterization tools such as UV-vis spectrometry, dynamic light scattering (DLS), and zeta potential measurements. By using this alternative method, the amount of silver in the solution is three times greater, and nanoparticles with a narrower size distribution are formed (between 6 and 70 nm in size). In contrast, the regular method produces particles of 3 and 100 nm. Zeta potential measurements indicate that the nanoparticles synthesized with the alternative method will be more stable than those from the regular method.
Methylene-Blue-Encapsulated Liposomes as Photodynamic Therapy Nano Agents for Breast Cancer Cells
Authors: Wu Po-Ting , Lin Chih-Ling , Lin Che-Wei , Chang Ning-Chu , Tsai Wei-Bor , Yu Jiashing
Published: December 2018

Methylene blue (MB) is a widely used dye and photodynamic therapy (PDT) agent that can produce reactive oxygen species (ROS) after light exposure, triggering apoptosis. However, it is hard for the dye to penetrate through the cell membrane, leading to poor cellular uptake; thus, drug carriers, which could enhance the cellular uptake, are a suitable solution. In addition, the defective vessels resulting from fast vessel outgrowth leads to an enhanced permeability and retention (EPR) effect, which gives nanoscale drug carriers a promising potential. In this study, we applied poly(12-(methacryloyloxy)dodecyl phosphorylcholine), a zwitterionic polymer-lipid, to self-assemble into liposomes and encapsulate MB (MB-liposome). Its properties of high stability and fast intracellular uptake were confirmed, and the higher in vitro ROS generation ability of MB-liposomes than that of free MB was also verified. For in vivo tests, we examined the toxicity in mice via tail vein injection. With the features found, MB-liposome has the potential of being an effective PDT nano agent for cancer therapy.
Engineering Charge Transfer Characteristics in Hierarchical Cu2S QDs @ ZnO Nanoneedles with p–n Heterojunctions: Towards Highly Efficient and Recyclable Photocatalysts
Authors: Han Donglai , Li Boxun , Yang Shuo , Wang Xinying , Gao Wei , Si Zhenjun , Zuo Qinghui , Li Yanhui , Li Yanwei , Duan Qian , Wang Dandan
Published: December 2018

Equipped with staggered gap p-n heterojunctions, a new paradigm of photocatalysts based on hierarchically structured nano-match-shaped heterojunctions (NMSHs) Cu2S quantum dots (QDs)@ZnO nanoneedles (NNs) are successfully developed via engineering the successive ionic layer adsorption and reaction (SILAR). Under UV and visible light illumination, the photocatalytic characteristics of Cu2S@ZnO heterojunctions with different loading amounts of Cu2S QDs are evaluated by the corresponding photocatalytic degradation of rhodamine B (RhB) aqueous solution. The results elaborate that the optimized samples (S3 serial specimens with six cycles of SILAR reaction) by means of tailored the band diagram exhibit appreciable improvement of photocatalytic activities among all synthesized samples, attributing to the sensitization of a proper amount of Cu2S QDs. Such developed architecture not only could form p–n junctions with ZnO nanoneedles to facilitate the separation of photo-generated carries but also interact with the surface defects of ZnO NNs to reduce the electron and hole recombination probability. Moreover, the existence of Cu2S QDs could also extend the light absorption to improve the utilization rate of sunlight. Importantly, under UV light S3 samples demonstrate the remarkably enhanced RhB degradation efficiency, which is clearly testified upon the charge transfer mechanism discussions and evaluations in the present work. Further supplementary investigations illustrate that the developed nanoscale Cu2S@ZnO heterostructures also possess an excellent photo-stability during our extensive recycling photocatalytic experiments, promising for a wide range of highly efficient and sustainably recyclable photocatalysts applications.
The Role of Succinate in the Regulation of Intestinal Inflammation
Authors: Connors Jessica , Dawe Nick , Van Limbergen Johan
Published: December 2018

Succinate is a metabolic intermediate of the tricarboxylic acid (TCA) cycle within host cells. Succinate is also produced in large amounts during bacterial fermentation of dietary fiber. Elevated succinate levels within the gut lumen have been reported in association with microbiome disturbances (dysbiosis), as well as in patients with inflammatory bowel disease (IBD) and animal models of intestinal inflammation. Recent studies indicate that succinate can activate immune cells via its specific surface receptor, succinate receptor 1(SUCNR1), and enhance inflammation. However, the role of succinate in inflammatory processes within the gut mucosal immune system is unclear. This review includes current literature on the association of succinate with intestinal inflammation and the potential role of succinate–SUCNR1 signaling in gut immune functions.
Regularization versus Renormalization: Why Are Casimir Energy Differences So Often Finite?
Authors: Visser Matt
Published: December 2018

One of the very first applications of the quantum field theoretic vacuum state was in the development of the notion of Casimir energy. Now, field theoretic Casimir energies, considered individually, are always infinite. However, differences in Casimir energies (at worst regularized, not renormalized) are quite often finite—a fortunate circumstance which luckily made some of the early calculations, (for instance, for parallel plates and hollow spheres), tolerably tractable. We will explore the extent to which this observation can be made systematic. For instance: What are necessary and sufficient conditions for Casimir energy differences to be finite (with regularization but without renormalization)? Additionally, when the Casimir energy differences are not formally finite, can anything useful nevertheless be said by invoking renormalization? We will see that it is the difference in the first few Seeley–DeWitt coefficients that is central to answering these questions. In particular, for any collection of conductors (be they perfect or imperfect) and/or dielectrics, as long as one merely moves them around without changing their shape or volume, then physically the Casimir energy difference (and so also the physically interesting Casimir forces) is guaranteed to be finite without invoking any renormalization.
Radiolabelled Aptamers for Theranostic Treatment of Cancer
Authors: Khalid Umair , Vi Chris , Henri Justin , Macdonald Joanna , Eu Peter , Mandarano Giovanni , Shigdar Sarah
Published: December 2018

Cancer has a high incidence and mortality rate worldwide, which continues to grow as millions of people are diagnosed annually. Metastatic disease caused by cancer is largely responsible for the mortality rates, thus early detection of metastatic tumours can improve prognosis. However, a large number of patients will also present with micrometastasis tumours which are often missed, as conventional medical imaging modalities are unable to detect micrometastases due to the lack of specificity and sensitivity. Recent advances in radiochemistry and the development of nucleic acid based targeting molecules, have led to the development of novel agents for use in cancer diagnostics. Monoclonal antibodies may also be used, however, they have inherent issues, such as toxicity, cost, unspecified binding and their clinical use can be controversial. Aptamers are a class of single-stranded RNA or DNA ligands with high specificity, binding affinity and selectivity for a target, which makes them promising for molecular biomarker imaging. Aptamers are presented as being a superior choice over antibodies because of high binding affinity and pH stability, amongst other factors. A number of aptamers directed to cancer cell markers (breast, lung, colon, glioblastoma, melanoma) have been radiolabelled and characterised to date. Further work is ongoing to develop these for clinical applications.
Risk of Transverse Myelitis Following Dengue Infection: A Systematic Review of the Literature
Authors: Badat Nafisa , Abdulhussein Dalia , Oligbu Peter , Ojubolamo Olakunle , Oligbu Godwin
Published: December 2018

Introduction: Dengue virus (DENV) is one of the most common arbovirus diseases, with a wide spectrum of presentation. Spinal cord involvement in dengue infection (DF) is rare. However, the risk of transverse myelitis (TM) following Dengue has not been systematically assessed. Methods: We undertook a systematic review of published English literature from January 1974 to December 2017 to assess risk of TM and outcomes following DF. Data sources included EMBASE, MEDLINE, Cochrane library, ISI web of knowledge, conference proceedings and references within identified articles. Results: We identified 242 potential studies, 62 were duplicates. A further 136 were excluded on the basis of title and abstract and 19 studies did not meet the eligibility criteria on full text screening. We included 25 publications involving 2672 cases of DF. A small proportion (10.8%, (289/2672)) had neurological complications, of which 2.3% (61/2672) was TM. For articles reporting epidemiological data, the neurological complication was twice in males compared to female 67.7% (130/192) vs. 32.7% (62/192) and 1.5-fold increase TM for males 59.3% (32/54) vs 40.7% (22/54). The mean age at presentation was 33.1years (range 0.75–61), with onset at 11.7days. The method of diagnosing TM due to DF was mainly IgM seropositivity 92% (n = 23/25) and the commonest treatment modality was steroid 78.3% (n = 18/23). Only half had full recovery 50.8% (n = 31/61). There was no mortality following dengue, however, the crude case fatality rate following TM was 3.3% (n = 2/61). Conclusion: This review highlights the risk of TM following dengue. Although neurological complications are rare, especially TM, once set in, it is associated with a significant morbidity.
Pharmacy Practice and Education in Slovenia
Authors: Božič Borut , Obreza Aleš , Atkinson Jeffrey
Published: December 2018

The PHARMINE (“Pharmacy Education in Europe”) project studied pharmacy practice and education in the European Union (EU) member states. The work was carried out using an electronic survey sent to chosen pharmacy representatives. The surveys of the individual member states are now being published as reference documents. This paper presents the results of the PHARMINE survey on pharmacy practice and education in Slovenia. In the light of this, we examine the harmonisation of practice and education in Slovenia with EU norms.
Computer-Aided Design of Molecularly Imprinted Polymers for Simultaneous Detection of Clenbuterol and Its Metabolites
Authors: Zhang Bingcheng , Fan Xin , Zhao Dayun
Published: December 2018

Molecular imprinting technology (MIT) offers an effective technique for efficient separation and enrichment of specific analytes from complicated matrices and has been used for illicit veterinary drug detectionin recent years due to its high selectivity, good chemical stability, and simple preparation. The development of in silico-based approaches has enabled the simulation of molecularly imprinted polymers (MIPs) to facilitate the selection of imprinting conditions such as template, functional monomer, and the best suitable solvent. In this work, using density functional theory (DFT), the molecularly imprinted polymers of clenbuterol and its metabolites were designed by computer-aided at B3LYP/6-31 + G (d, p) level. Screening molecular imprinting components such as functional monomers, cross-linkers, and solvents has been achieved in the computational simulation considerations. The simulation results showed that methacrylic acid (MAA) is the best functional monomer; the optimal imprinting ratio for both clenbuterol (CLB) and its dummy template molecule of phenylephrine (PE) to functional monomer is 1:3, while the optimal imprinting ratio for the two dummy template molecules of CLB’s metabolites is 1:5. Choosin gethyleneglycol dimethacrylate (EDGMA) as a crosslinker and aprotic solvents could increase the selectivity of the molecularly imprinted system. Atoms in Molecules (AIM) topology analysis was applied to investigate the template-monomer complexes bonding situation and helped to explain the nature of the reaction in the imprinting process. These theoretical predictions were also verified by the experimental results and found to be in good agreement with the computational results. The computer-simulated imprinting process compensates for the lack of clarity in the mechanism of the molecular imprinting process, and provides an important reference and direction for developing better recognition pattern towards CLB and its metabolite analytes in swine urine samples at the same time.
Criticality of the Self-Heating Effect in Polymers and Polymer Matrix Composites during Fatigue, and Their Application in Non-Destructive Testing
Authors: Katunin Andrzej
Published: December 2018

The self-heating effect is a dangerous phenomenon that occurs in polymers and polymer matrix composites during their cyclic loading, and may significantly influence structural degradation and durability as a consequence. Therefore, an analysis of its criticality is highly demanding, due to the wide occurrence of this effect, both in laboratory fatigue tests, as well as in engineering practice. In order to overcome the problem of the accelerated degradation of polymer matrix structures, it is essential to evaluate the characteristic temperature values of self-heating, which are critical from the point of view of the fatigue life of these structures, i.e., the temperature at which damage initiates, and the safe temperature range in which these structures can be safely maintained. The experimental studies performed were focused on the determination of the critical self-heating temperature, using various approaches and measurement techniques. This paper present an overview of the research studies performed in the field of structural degradation, due to self-heating, and summarizes the studies performed on the evaluation of the criticality of the self-heating effect. Moreover, the non-destructive testing method, which uses the self-heating effect as a thermal excitation source, is discussed, and the non-destructivity of this method is confirmed by experimental results.
Levinas, Simmel, and the Ethical Significance of Money
Authors: Buckman Christopher
Published: December 2018

An examination of Emmanuel Levinas’ writings on money reveals his distance from—and indebtedness to—a philosophical predecessor, Georg Simmel. Levinas and Simmel share a phenomenological approach to analyses of the proximity of the stranger, the importance of the face, and the interruption of the dyadic relationship by the third. Money is closely linked to the conception of totality because money is the medium that compares heterogeneous values. Levinas goes beyond Simmel in positing an ethical relation to money permitting transcendence.
Views on Spirituality in Old Age: What Does Love Have to Do with It?
Authors: Rykkje Linda
Published: December 2018

This paper addresses the importance of providing spiritual care for older people within the context of nursing. Based on the author’s doctoral thesis, the importance of love in relation to spirituality and spiritual care will be discussed herein. The methodology is based upon Gadamer’s hermeneutical philosophy, and the included material is one qualitative metasynthesis, interviews of 17 older people, a research synthesis of articles concerning connectedness and love, and a book by Paul Tillich. Love in connectedness was found as a universal force in spirituality, and different forms of love emerged in relation to spiritual needs in older people care. Furthermore, love as a re-unifying and connecting force may foster confirmation of human worth and dignity, enable serving others in reciprocate love, longing towards being part of something larger than oneself, and holiness in the sense of pursuing existential meaning or religiousness.
The Power of Carl Schmitt: Fascism, Dualism and Justice
Authors: Cohen Richard A.
Published: December 2018

The purpose of this paper is to show that underlying Schmitt’s account of fascist politics lies a Gnostic-like metaphysical dualism separating the realms of value and power. Contrary to the normative political tradition of the West, which defends ethical politics, Schmitt—jurist and theorist of the Nazis—aligns himself with Machiavelli and Hobbes to defend realpolitik for which sovereignty is ultimately a function of the Dictator’s will alone. This paper shows the contradiction within such a position, which criticizes values in politics, but by its advocacy and its defense of the Dictator’s willing, relies on valuation, choice and hence, the ethical.
The Business Model and Innovation Analyses: The Sustainable Transition Obstacles and Drivers for the Hospital Supply Chains
Authors: Lopes Catia Milena , Scavarda Annibal José , Carvalho Mauricio Nunes Macedo de , Korzenowski André Luis
Published: December 2018

This research aims to discuss the business model themes supported by the innovation regarding the sustainable transition difficulties to promote the hospital supply chains. A model for future applications and empirical analyzes in the health service area is proposed. In the current hospital scenario, the systems are characterized by the individualistic attention of the closed business models, hampering the promotion of the business models, the innovation, and the sustainable transitions as the sustainable supply chain (SSC) enablers. The survey evaluates the private hospital chain in Brazil. The model was evaluated by seven specialists indicated by the main private Brazilian hospitals that are accredited by Joint Commission International and Public Ministry. The discussion presented seeks to advance the observation and the understanding of the relationships among the business models, the innovation, the sustainable transitions, and the sustainable supply chains in the health socioeconomic context through the lens of the service provider, without exhausting these themes separately. The main results are the issues related to the difficulties of sustainable transition to promote the SSC in the hospital context, showing the elements into which the hospitals are inserted and helping to close the gap in the literature on the subject. Sustainable transitions, along with the SSC, present themselves as rich and challenging themes, but are beneficial for conducting dialogues between approaches.
The Potential of Reflectance and Laser Induced Luminescence Spectroscopy for Near-Field Rare Earth Element Detection in Mineral Exploration
Authors: Lorenz Sandra , Beyer Jan , Fuchs Margret , Seidel Peter , Turner David , Heitmann Johannes , Gloaguen Richard
Published: December 2018

New energy, transport, computer and telecommunication technologies require an increasing supply of rare earth elements (REEs). As a consequence, adequate and robust detection methods become essential for the exploration and discovery of new deposits, the improved characterization of existing deposits and the future recycling of today’s high-tech products. Within this paper, we investigate the potential of combining passive reflectance (imaging and point sampling) with laser stimulated luminescence (point sampling) spectroscopic measurements across the visible, near and shortwave infrared for REE detection in non-invasive near-field mineral exploration. We analyse natural REE-bearing mineral samples from main REE-deposits around the world and focus on challenges such as the discrimination of overlapping spectroscopic features and the influence of the mineral type on detectability, feature position and mineral matrix luminescence. We demonstrate that the cross-validation of results from both methods increases the robustness and sensitivity, provides the potential for semi-quantification and enables the time- and cost-efficient detection of economically important REE, including Ce, Pr, Nd, Sm, Eu, Dy, Er, Yb and potentially also Ho and Tm.
Identifying Emerging Reservoirs along Regulated Rivers Using Multi-Source Remote Sensing Observations
Authors: Zhang Wensong , Pan Hang , Song Chunqiao , Ke Linghong , Wang Jida , Ma Ronghua , Deng Xinyuan , Liu Kai , Zhu Jingying , Wu Qianhan
Published: December 2018

The number of reservoirs is rapidly increasing owing to the growth of the world’s economy and related energy and water needs. Yet, for the vast majority of reservoirs around the world, their locations and related information, especially for newly dammed reservoirs, are not readily available due to financial, political, or legal considerations. This study proposes an automated method of identifying newly dammed reservoirs from time series of MODIS-derived NDWI (normalized difference water index) images. Its main idea lies in the detection of abrupt changes in the NDWI time series that are associated with land-to-water conversion due to the reservoir impoundment. The proposed method is tested in the upper reach of the Yellow River that is severely regulated by constructed reservoirs. Our results show that five newly dammed reservoirs were identified in the test area during 2000–2018. Validated against high-resolution Google Earth imagery, our method is effective to determine both locations of the emerging medium-size reservoirs and the timing of their initial water impoundments. Such information then allows for a refined calculation of the reservoir inundation extents and storage capacities through the combination of higher-resolution Landsat imagery and SRTM DEM. The comparison of our estimated reservoir areas and capacities against documented information further indicates that the integration of multi-mission remote sensing data may provide useful information for understanding reservoir operations and impacts on river discharges. Our method also demonstrates a potential for regional or global inventory of emerging reservoirs, which is crucial to assessing human impacts on river systems and the global water cycle.
Using TSX/TDX Pursuit Monostatic SAR Stacks for PS-InSAR Analysis in Urban Areas
Authors: Wang Ziyun , Balz Timo , Zhang Lu , Perissin Daniele , Liao Mingsheng
Published: December 2018

Persistent Scatterer Interferometry (PS-InSAR) has become an indispensable tool for monitoring surface motion in urban environments. The interferometric configuration of PS-InSAR tends to mix topographic and deformation components in differential interferometric observations. When the upcoming constellation missions such as, e.g., TanDEM-L or TWIN-L provide new standard operating modes, bi-static stacks for deformation monitoring will be more commonly available in the near future. In this paper, we present an analysis of the applicability of such data sets for urban monitoring, using a stack of pursuit monostatic data obtained during the scientific testing phase of the TanDEM-X (TDX) mission. These stacks are characterized by extremely short temporal baselines between the TerraSAR-X (TSX) and TanDEM-X acquisitions at the same interval. We evaluate the advantages of this acquisition mode for urban deformation monitoring with several of the available acquisition pairs. Our proposed method exploits the special properties of this data using a modified processing chain based on the standard PS-InSAR deformation monitoring procedure. We test our approach with a TSX/TDX mono-static pursuit stack over Guangzhou, using both the proposed method and the standard deformation monitoring procedure, and compare the two results. The performance of topographic and deformation estimation is improved by using the proposed processing method, especially regarding high-rise buildings, given the quantitative statistic on temporal coherence, detectable numbers, as well as the PS point density of persistent scatters points, among which the persistent scatter numbers increased by 107.2% and the detectable height span increased by 78% over the standard processing results.