bluuebunny/crossref_metadata_2025 huggingface dataset:
Humans Emerging beyond Universe with Metaverse, is it possible? How?
Authors: Sadiya Samreen
Published: January 2022

Abstract: In recent years, the metaverse has attracted enormous attention from around the world with the development of related technologies. The expected metaverse should be a realistic society with more direct and physical interactions, while the concepts of race, gender, and even physical disability would be weakened, which would be highly beneficial for society. However, the development of metaverse is still in its infancy, with great potential for improvement. Regarding metaverse's huge potential, industry has already come forward with advance preparation, accompanied by feverish investment, but there are few discussions about metaverse in academia to scientifically guide its development. In this paper, we highlight whether it is possible for mankind to be able to emerge beyond universe with metaverse. Then we propose a nine-layer metaverse architecture from a macro perspective, containing experience, discovery, creator economy, spatial computing , decentralization, human interface, infrastructure, virtuality, and ecosystem. Moreover, we journey toward both a historical and novel metaverse, on how metaverse helps humans to not just watch internet but enter into it, with a detailed timeline and table of specific attributes. Lastly, we illustrate our implemented blockchain-driven metaverse prototype of a university campus and discuss the prototype design and insights. the most common conceptions of the metaverse stem from science fiction. Here, the Metaverse is typically portrayed as a sort of digital ” jacked-in” internet-a manifestation of actual reality, but one based in a virtual)often theme park-like)world, such those portrayed in Ready Player One and The Matrix. And while these sorts of experiences are likely to be an aspect of the Metaverse, this conception is limited in the same way movies like Tron portrayed the internet as a literal digital “information superhighway” of bits. Keywords: nine-layer metaverse, Tron, blockchain-driven, development, potential to improve .
Studi meta analisis: Efektivitas terapi menulis dalam menurunkan kecemasan orang dewasa dengan pengalaman traumatis
Authors: Sarahdevina Putu Nitya , Yudiarso Ananta
Published: January 2022

Anxiety is often experienced by adults who have a less pleasant life experience. Writing therapy is an intervention that adults can use to express anxiety. This study aims to find out the effectiveness of writing therapy in lowering anxiety levels. The study used a meta-analysis method through a literature review of 14 research articles corresponding to research variables. The total number of participants in the study was 1,593. Data is analyzed by adjusting the effect size. The analysis results in effect size value obtained from fixed effects are -0.06 (95% Cl = -0.167 to 0.042, P =0.2434) and I² (inconsistency) by 66.9%, which means that writing therapy has little effect in lowering anxiety levels. Writing therapy has little effect on decreasing anxiety levels. Writing therapy can be given in conjunction with other interventions in order to provide more optimal effects
Nurses’ experience with burnout and therole of perceived social support
Authors: Yanto Rizal Febri , Djudiyah Djudiyah , Syakarofath Nandy Agustin
Published: January 2022

Nurses are among the health professionals at the forefront of dealing with patients identified as covid-19, particularly vulnerable to psychological fatigue. Various studies have found that perceived social support can assist nurses in dealing with difficult situations. The study's goal was to see how perceived social support affected nurses' burnout. A total of one hundred nurses took part in this study, which was conducted using random sampling techniques. The Multidimensional Scale of Perceived Social Support (MSSPS) and the Burnout Assessment Tool (BAT) are tools used to assess perceived social support and burnout, respectively. The results of the simple linear regression analysis revealed that perceived social support had an effect on nurse burnout in Balikpapan (adjustedR2 = 0.245; F(31,793) = 99, p = 0.001). The more social support nurses have, the less burnout they experience.
FORMULATION, DEVELOPMENT AND IN-VITRO EVALUATION OF A BAMBUTEROL HYDROCHLORIDE IN-SITU GELLING SYSTEM FOR NASAL DELIVERY
Authors: Galankar Vipulata P.
Published: January 2022

The goal of this project was to design, develop, and in-vitro evaluation of an in-situ gelling system for nasal administration of Bambuterol hydrochloride. All of the batches were prepared using different concentration of pectin, given different doses of simulated nasal electrolyte solution (SNES) i.e., 0.1 ml to 2.0 ml. All batches and formulation batches with a composition of 0.8 percent low methoxyl pectin underwent an in vitro gelation testing. The pH of the formulation reduced as the pectin content increased due to the acidic nature of pectin. The drug concentration was greater than 95%, and the apparent viscosity of the sol and gel was measured using a Brookfield viscometer (Rotational Viscometer Model). When the concentration of gelling polymer was increased from 0.5 to 1.0 percent, the gel strength (SOL) increased from 0.6 to 1 sec. The gel strength (GEL) increased from 0.7 to 13 seconds as a result of gelation. In vitro drug release experiments showed that the resulting formulations could release the medication for up to 10 hours when Higuchi kinetics were applied to all of them. The gels were stable across the six-month test period, according to the accelerated stability studies. There was no drug-polymer interaction, according to DSC and XRD analyses. Based on these findings, in situ nasal gel could be a possible drug delivery strategy for bambuterol hydrochloride, allowing it to bypass first-pass metabolism and hence improve bioavailability.
SOME MEDICINAL PLANTS WITH ANTI-DIABETIC ACTIVITY IN EXPERIMENTAL ANIMALS
Authors: Nikumbh Komal K
Published: January 2022

Diabetes is a long-term endocrine disease that affects people all over the world and is getting increasingly common. Because of its multisystem involvement and life-threatening effects, diabetes has become a major health concern for people of all ages in recent years. In 2019, diabetes was directly responsible for around 1.5 million fatalities. It's the primary cause of blindness, kidney failure, heart attack, stroke, and lower-limb amputations. Despite advances in pharmacological research and therapy, effective diabetes management remains a problem. Many therapeutic plants have demonstrated promising outcomes in animals in studies, and these findings can be applied to humans. This review examines the antidiabetic activity of common medicinal herbs such as Gymnema sylvestre, Swertia chirata, Momordica charantia, and others in experimental animals
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF COMBINATION OF ANTI-ASTHMATIC DRUGS MONTELUKAST AND DOXOFYLLINE
Authors: Kapase Sachin N.
Published: January 2022

For qualitative and quantitative analysis, various analytical techniques are available such as Ultraviolet (UV) Spectrophotometry, High-performance liquid chromatography (HPLC), High-performance thin layer chromatography (HPTLC). As per literature survey, there are some UV, HPLC, Ultra-Performance Liquid Chromatography (UPLC) and HPTLC analytical methods are developed for Montelukast and Doxofylline individually and in a combination with other drugs too, since yet there are no significant stability studies indicating HPLC method reported for Montelukast and Doxofylline combinations. In the current study, the HPLC method is developed and validated for simultaneous quantitative estimations of Montelukast and Doxofylline. These present techniques are more efficient and sensitive as compared to other analytical techniques.
Análisis descriptivo de la representatividad de la prensa en comunidades locales de Chile
Authors: Chamorro Maldonado Miguel Alejandro
Published: January 2022

El artículo es el resultado de una investigación realizada en las ciudades de Quillota y San Felipe, Región de Valparaíso, para mostrar el grado de representatividad que tiene la prensa local con su comunidad. Para lograr comprender la representatividad se realiza un estudio descriptivo, aplicando una encuesta estructurada a los lectores de los diarios para acercarse a la comunidad y observar la realidad. Dicha técnica permitió apreciar las respuestas de los receptores, calibrarla estadísticamente y vincular a la realidad tratada por ambos diarios en las comunas respectivas.
Instalaciones franciscanas en el puerto de Valparaíso en los siglo XVII - siglo XX
Authors: Jiménez Vergara Cecilia
Published: January 2022

Esta investigación permitió reconstruir la historia de las instalaciones franciscanas aledañas a la iglesia La Matriz, entre el siglo XVII hasta su demolición a mediados del siglo XX, basada en registros historiográficos documentales, de diversas órdenes religiosas, relacionadas con la iglesia, convento, y colegios que albergaron.

Asimismo, junto con reconstituir gráficamente las planimetrías, descubrir la estrecha relación del conjunto franciscano con el espacio urbano que lo antecedía denominado Plazuela San Francisco donde se realizaban actividades “sacras “ y “profanas” tales como  procesiones, misas, obras de teatro,  peleas de gallo y  corridas de toros.   La Plazuela  persistió como espacio público aún después de la demolición de la Iglesia y convento hasta las últimas décadas del siglo XX. cuando fue transferida en comodato a la P.D.I.

La investigación determinó que este espacio urbano posee huellas  que forman parte de la memoria colectiva y constituye un patrimonio olvidado necesario de recuperar no sólo para los vecinos y la ciudad, sino también  factible de incorporar al Área Histórica de Valparaíso reconocida por la UNESCO como Patrimonio Mundial.
Survey Based Road Safety Analysis to Understand the Perspective of the General Public
Authors: Khan Alina , Gajbhiye Nilima
Published: January 2022

The number of road traffic deaths continues to climb, reaching 1.35 million deaths globally in 2016 and road traffic injury is now the leading cause of death for children and young adults aged 5–29 years (WHO, 2018). Road safety is officially recognized as a global safety issue and it is also included in the Sustainable Development Goals. This is a questionnaire based analysis, which aims to understand the outlook of the general public regarding the current road safety system and to understand the level of awareness regarding the same. It also aims to compare the perspective of drivers and non-drivers towards traffic rules. Majority of the participants were from the age group of 15-30 years as they are most directly affected by road accidents. Our objective is to understand the shortcomings in the current road safety system through the perspective of the general public, which can then help in implementing a more efficient system in order to decrease the number of road accidents. Inadequate traffic system also significantly affects the economic growth of the region. According to the World Road Statistics, 2018, India ranks 1st in the number of road accident deaths hence there is an urgent need to understand the root cause for such a high number of accidents and to find solutions for this issue. Our results show that there is a need to implement stricter rules for road safety and this perspective of the general public is not affected by the status of the individual (driver, non-driver). It also suggests the need for increasing the level of licence tests conducted. Increasing awareness at an early stage among the people regarding the seriousness of following traffic rules can help prevent road accidents at the baseline level.
Pharmacological Properties And Bioavailability Studies Of 3-Methyl Quinoline
Authors: lenin Santhadani , sujatha Ramasamy , Palanisamy Shanmugasundaram
Published: January 2022

Amongst heterocyclic compounds, quinoline is the privileged scaffold that appears as a significant assembly motif for the development of new drug entities. Quinoline and its derivatives tested with diverse biological activity constitute an important class of compounds for new drug development. Therefore, many scientific communities have developed these compounds as intent structures and evaluated their biological activities. Our goal is to discover bioavailability, relative bioavailability, definition and assembly factors that may influence the bioavailability of a medication item, physiologic and other factors influencing bioavailability, characteristics of medications with a high risk of bioavailability, and evaluation of bioavailability from pharmacologic just as a therapeutic reaction. From the GCMS analysis bioactive compound chosen was Quinoline compounds and it is further investigated. The compound 3-methyl Quinoline, solved Lipinski‟s rule and it showed drug resemblance (Mi Log P esteem < 5, TPSA < 140 Ǻ2, n infringement = 0, sub-atomic mass < 500, N rotb < 5, n HBD <5 and n HBA<8). As the bioavailability score is high it can be used for further studies. This finding revealed that the bulk of pharmacological characteristics and bioavailability investigations were conducted using ADME and toxicity, rather than the absence of viability. From mid-one, the substance 3-methyl Quinoline measures are being taken in the drug business to improve achievement rates by contemplating the ADME and toxicological perspectives in medication disclosure.
Efficacy of Indoor Residual Spray (Bendiocarb 80%) for Malaria Control in Sennar State, Sudan
Authors: Adam Eltahir Walid , Osman Elamin Mohamed , A Osman Ahmed , Abdullah Natto Hatim , Hassan Mohamed Nazik
Published: January 2022

Malaria is a worldwide public health problem, in 2017, and an estimated 237 million cases of malaria occurred worldwide compared with 211 million cases in 2010 and 219 million cases in 2015. Several countries used Indoor Residual Spray (IRS) (Bendiocarb 80%) to combat Malaria. The study aimed to evaluate the efficacy of IRS (Bendiocarb 80%) applied in Sennar state, Sudan in which Malaria is endemic. We used Pyrethrum spray collection, Bio efficacy of IRS using Cone methods and Malaria cases reporting to evaluate the efficacy of Indoor Residual Spray. The efficacy of IRS was tested by cone bioassay for four months (August- November 2017) for susceptible strains of Anopheles Mosquitoes. The recorded mortality of the 4 months was 99±1.23, 95±5.14,48±18.37, 23±9.26 respectively and mortality for the field strain of Anopheles mosquito in the study period was 100±0.0; 88.5±7.4; 43.8±20.1; and 0.7±0.8 respectively. The Malaria incidence rates for four months after application of Indoor Residual Spray in Sennar State (September, October, November and December 2017) were (5.18±3.4; 5.0±3.3; 4.31±3.1; and 5.15±3.9 respectively). This study found that there was a reduction in the total number of the collected Anopheles gambiae, female mosquito from 143 to 46, in unfed mosquitoes (UF) from 22 to 0, in fresh feed mosquitoes (FF) from 60 to18, in half gravid mosquitoes (HG) from 0.29 to 18, in gravid mosquitoes (G) from 32 to16, in density/room from 4.1 to 1.3, and in Man Biting Rate (MBR) from 2.5 to 0.7.Data analysed using statistical package for social sciences, version (22), Chi- square test used for the analysis of comparison, probability value of less than 0.05 considered statistically significant. The study concluded that there was a reduction in (Anopheles gambiae) density and Malaria cases after Indoor Residual Spray application in Sennar state, Sudan
In Vitro Antimicrobial Activity Of Semecarpus anacardiumNuts Against human Pathogenic Bacteria.
Authors: Sharma Alka , R.A. Sharma  , Yadav Nirmala
Published: January 2022

Semecarpus anacardium is a toxic nature plant and it belongs to family Anacardiaceae.It is well known for its use in ayurveda and siddha as a potent medicinal herb since ancient times. According to Ayurveda Semecarpus anacardium is also named as Bhallataka and Dhobi nut. Phytochemical and pharmacological analyses of Semecarpus anacardium nut extracts shows a variety of bioactive compounds such as bioflavonoids, bhilawanols, phenolic compounds, minerals and glycosides which shows various medicinal properties.The various extract of Semecarpus anacardium has been screened for phytochemicals and exhibit the presence of Phenols, Steriods, Alkaloids, Flavonoids, Saponins, Tanins and Phytosterols. Antimicrobial susceptibility was assayed by the agar well diffusion method and three concentration of plant extract were prepared in 10% DMSO. Each bacterial suspension was inoculated on MullerHinton agar plates. Disc of Streptomycin was used as positive control and 10% DMSO soaked filter paper disc was used as negative control. Plates were incubated for 18 hr at35±20C. After the incubation, the antibacterial activities of the extracts were determined by measuring the diameter of the inhibition zone around the well that was filled with the extract. The highest antibacterial activity was exhibited by the acetone extract against Enterococcus faecalis (IZ=27mm) and chloroform extract against Proteus vulgaris (IZ=23mm). Methanolic extract of nuts showed significant activity against five human pathogenic bacteria.The results revealed that various extracts of S. anacardium nuts showed significant antibacterial activity against Staphylococcus aureus, Klebsiella pneumoniae, Enterococcus faecalis, Proteus vulgaris, Pseudomonas aeruginosa. It provides preliminary information for further phytochemical and pharmacological analysis on the chemical constituency of the plant extracts. The results of the antimicrobial activity of various sequential extracts were in agreement with the uses of the extracts of Semecarpus anacardium in traditional medicine for the treatment of bacterial diseases.
Histological Study Of Red Grape Juice On Rat's Liver Exposed To Cigarette Smoke
Authors: D. Alalwani Aisha , A. Khalifa Sana , O. Aljuhani. Haifa
Published: January 2022

Smoking considered being one of the oldest habits. It demonstrated that smoking has many disease-causing effects. This study examined the effects of red grape juice on liver tissue, liver function, and blood parameters in rats exposed to cigarette smoke. Fifty rats randomly divided into five groups: Group I; Control animals, Group II; rats exposed to cigarette smoke, Group III; rats exposed to cigarette smoke and treated with red grape juice, Group IV; rats fed with red grape juice only. Group V: rats exposed to smoking for a month and then left without exposure for another month (effect of smoking withdrawal). At the end of the experiment, blood samples analyzed for liver enzymes and complete blood cell count. Liver and body weights recorded. The liver tissue stained with H&E and subjected to histopathological analysis. Statistical analysis done among all groups and significance of results compared. The level of liver enzymes and white blood cells in animals of Group II increased significantly compared to Group I. Several histopathological changes in liver tissue were observed in Group II such as necrosis, inflammatory cellular infiltration leading to granulomas, also noted dilatation, congestion in the portal tract and vascular blood vessels, while Group III showed near-normal liver tissue and biochemical measurements. Group V did not show any improvement in biochemical and histological parameters. The present study shows that red grape juice is an effective antioxidant that decreases liver tissue damage in rats exposed to cigarette smoke.
Pengaruh kurs, inflasi, PDB dan harga karet internasional terhadap ekspor karet Indonesia Ke Tiongkok dan Amerika Serikat
Authors: Fihri Faisal , Haryadi Haryadi , Nurhayani Nurhayani
Published: January 2022

This study aims to: 1) calculate and analyze the development of exchange rates, inflation, GDP, international rubber prices, and Indonesian rubber exports to China and the United States. 2) To determine the income contribution of women workers in Talang Village, 3). To calculate and analyze the factors that affect the export of Indonesian rubber to China and the United States. The analytical method used is descriptive quantitative using multiple linear regression analysis. The results show that the exchange rate development fluctuated from 2001 to 2019, with an average exchange rate development from 2001 to 2019 of 3.13 percent. Then the average general annual inflation of Indonesia for 19 years with inflation developments that occur up and down or fluctuate. The average growth of rubber prices is 9.24 percent. Furthermore, the volume of rubber exports to China in 2001-2019 tends to decrease. The average development of rubber export volume to China in 2001-2019 was -1.95 percent. Meanwhile, the development of rubber export volume to America in 2001-2019 tends to increase. The average growth of rubber export volume to China in 2001-2019 was 1.34 percent. Based on the results of multiple linear regression, the importance of rubber exports to China is influenced by the variables of the exchange rate, GDP, and rubber prices. Meanwhile, the rubber price variable only affects the volume of rubber exports to America.
 Keywords: Export of rubber, Exchange rate, Inflation, GDP, Rubber price
Analisis pendapatan UMKM di Kawasan Wisata Candi Muaro Jambi (sebelum dan semasa pandemi Covid-19)
Authors: Sartika Rakasiwi Ajeng , Zulfanetti Zulfanetti , Umiyati Etik
Published: January 2022

The main objectives of this study are: First, to determine the socio-economic characteristics of MSME actors in the Muaro Jambi temple. Second, analyze the income of MSME actors in Muaro Jambi Temple. Third, knowing the factors that influence the income of MSMEs in Muaro Jambi Temple. Fourth, analyze the impact of Covid-19 on MSME income in the Muaro Jambi temple area. The data used is sourced from the respondent's identity (sample) and a list of questions (questionnaire) conducted in the Muaro Jambi temple area. The sample used in this study was 50 respondents. The method used to analyze this research is descriptive quantitative. This study uses multiple linear regression analysis based on Ordinary Least Square (OLS). The factors that significantly influence this study are labor and length of business. Furthermore, the variables of age and gender have no significant effect.
Keywords: Labor, Length of business. Age, Gender, Income
REVITALIZATION OF MARITIME SILK ROAD BASED ON THE SECURITY IMPLICATIONS AND COOPERATION
Authors: Akib Haedar , Syaefullah Lutfi , Abdul Gani Hamsu
Published: January 2022

The revitalization of the Silk Road as a trade route, cultural exchange, religion, science and civilization based on the “Maritime Silk Road” (MSR) is the focus of strategic studies and international relations. ASEAN countries, including Indonesia in the MSR route and the contestation of the United States and China who are fighting for dominance in the Indo-Pacific region, face challenges and opportunities. The results of this research, which uses a normative approach, show that the revitalization of the MSR may give positive impacts to China’s foreign affairs for the good interaction and communication among people by economic trade.
FAILED STRATEGY? THE LEGACY OF BARACK OBAMA’S PRESIDENCY IN THE MIDDLE EAST AND NORTH AFRICA
Authors: Lewicka Magdalena , Dahl Michał
Published: January 2022

The purpose of this paper is to verify whether “a failed strategy”, a phrase commonly used in the literature, is an adequate description of Barack Obama’s legacy in the Middle East and North Africa. Based on the selected political manifestos and actions in the sphere of diplomacy, it has been proven that the Middle East and North Africa was not a priority to the decision-makers in Washington in the years 2009–2012, unlike in the years 2005–2008. However, although President Obama did not manage to implement most of his original plans, he achieved a few significant successes, the most notable of which is the withdrawal of U.S. troops from Iraq and the conclusion of the nuclear deal with Iran. Authors seek to contextualize and explain Obama’s failures and successes, arguing that using the phrase “a failed strategy” does not reflect the complexity of the problems analyzed.
ORÇAMENTO EM DEFESA E CAPACIDADES ESTRATÉGICAS: DISSIMILARIDADES ENTRE OS PAÍSES DA AMÉRICA DO SUL
Authors: Neves Angela Nogueira , Franchi Tássio
Published: January 2022

We take into account that interpretations of security complexes, traditions of long peace, and violent peace do not fully explain how South American countries are organized regarding Defense. Given those, we ran a cluster analysis with data from the Stockholm International Peace Research Institute (SIPRI) and Military Balance report with economic defense expenditure and capabilities investment from South American countries to identify how they are organized, determining those that are most similar to each other (which would form complexes) and how they differ from the others (dissimilarities). The results showed four different clusters: the first formed by Chile, Peru, Argentina, and Bolivia; the second by Brazil, Colombia, Ecuador and Paraguay; the third only by the Guyana; and the fourth, formed only by Uruguay. We interpreted these clusters considering the history of conflicts, current countries threats and treaties.
PRIORIZAÇÃO DE ACORDOS MULTILATERAIS DE CONTROLE DE EXPORTAÇÃO DE PRODUTOS DE DEFESA E TECNOLOGIAS SENSÍVEIS POR PROCESSO DE ANÁLISE HIERÁRQUICA
Authors: Gaviao Luiz Octavio , Dutra Luciano Dias , Kostin Sergio
Published: January 2022

This paper proposes a model to support the decision to choose which multilateral export control regime of defense products and sensitive technologies in which Brazil does not yet participate, namely, Wassenaar Arrangement, Australia Group and Zangger Committee, should be prioritized for adhesion. For the development of this model, the Analytic Hierarchy Process (AHP) method was used, considered adequate for solving problems where criteria are qualitative and decisions tend to be based on personal experiences. The hierarchical structure of the problem used seven criteria (Country Legislation, Regulatory System, Licensing Structure, Enforcement Capacity, International Cooperation, Costs of Adhesion and Benefits for the Defense Industrial Base) to compare the three mentioned agreements. A questionnaire was set up and specialists related to National Defense were selected to answer them, after which their answers were collected, standardized, processed and analyzed. At the end, the agreements were ordered by preference to support decision making, illustrating the application of the proposed model.
Mediación pedagógica de lecturas en inglés para estudiantes con un nivel básico del idioma en la cátedra de Educación Preescolar UNED, Costa Rica
Authors: Solís Solís Delia María , Acevedo Nevermann Katherine
Published: January 2022

La necesidad de desarrollar competencias lingüísticas en un segundo idioma en la primera infancia costarricense ha generado que las Universidades estatales empiecen a revisar sus programas de estudio para la formación de formadores. Esta realidad y la mediación de materiales en inglés como requisito de acreditación propiciaron la necesidad de incorporar lecturas en un segundo idioma en las diferentes asignaturas de la Carrera de Educación Prescolar de la UNED, a sabiendas de que la población carece del dominio de este. La intención de este estudio fue mediar lecturas en inglés con la  estrategia basadas en tareas y trabajo cooperativo en estudiantes de diplomado con un dominio básico del idioma. Ambas estrategias se escogieron por ser apropiadas para el trabajo a distancia. El material elegido por expertos fue una lectura y un video, los cuales cumplen los siguientes requisitos: 1- la lectura: corta (no más de 5 páginas), vocabulario simple e imágenes ilustrativas. 2-el video: cortos (no más de 4 minutos) y con subtítulos en inglés.  La mediación y evaluación del material se realizó en la plataforma, a través de actividades de predicción. Las actividades evaluaron la habilidad de comprensión, escucha y se presentaron en un foro académico. Se encontró que mientras la población estudiantil pueda utilizar todos los recursos visuales, auditivos y conocimientos previos en las actividades de evaluación, el idioma como tal no representa un obstáculo. Estos resultados sugieren el beneficio de la estrategia del trabajo en tareas, el trabajo colaborativo y las actividades de predicción como técnicas para mediar el material en otro idioma.
Características del liderazgo de la jefatura departamental en matemática de un centro de alto desempeño en educación secundaria en Chile
Authors: Maureira Cabrera Oscar , Guíñez Gutiérrez Carla , Atenas Alister Nelly
Published: January 2022

El objetivo del siguiente trabajo, es caracterizar el liderazgo y factores contextuales del jefe del Departamento de Matemática de un centro de educación secundaria chileno, con trayectoria de desempeño escolar notable, que ha institucionalizado la departamentalización como estrategia de sostenibilidad de mejora. Mediante un enfoque descriptivo, basado en un estudio de caso único, se realizaron entrevistas semiestructuradas a la jefa de departamento y encargadas de la Unidad Técnico-Pedagógica del centro. Los resultados indican que tal cargo y unidad departamental responde, de manera simultánea, a lineamientos políticos internos de la dirección escolar y a características de liderazgo docente que fortalecen la colaboración entre pares. Como principal conclusión, se reconoce la potencialidad didáctica del quehacer departamental y el valor de las competencias de liderazgo pedagógico, asumido por la jefatura para sustentar la efectividad de la enseñanza de matemática y favorecer el desarrollo profesional docente situado.
Resistência, necropolítica e fantasias de vingança – Bacurau (2019), de Kleber Mendonça Filho e Juliano Dornelles
Authors: Ferreira Carolin Overhoff , Lingna Nafafé José
Published: January 2022

Bacurau (BACURAU, 2019) de Kleber Mendonça Filho e Juliano Dornelles foi o filme brasileiro mais polêmico de 2019. Estreou no Festival de Cannes 2019 onde obteve o Prêmio especial do Júri e depois ganhou mais distinções nacionais e internacionais. Foi elogiado e criticado como filme de resistência contra o atual governo de Bolsonaro, seu discurso sexista, racista e homofóbico. Este artigo procura analisar três aspetos centrais do filme: 1) a maneira como se dá essa resistência contra os invasores norte-americanos que utilizam o povoado de Bacurau para um videogame real, valendo-se de sua população como alvos vivos; 2) o emprego da necropolítica, que possui historicamente uma dimensão mais violenta no Brasil devido ao trafico de escravizados e à escravidão, e que está atrás da venda da vila pelo prefeito Tony Júnior; e 3), a fantasia de vingança relativamente à essa opressão e à qual o filme dá expressão por meio de um banho de sangue violento quando o povoado se defende contra os invasores. O maior objetivo deste artigo e da analise desses aspetos consiste em compreender se o filme contribui para o debate sobre racismo no Brasil, no sentido de promover a discussão acerca da necessária decolonização das mentes para enfrentar o fundamental problema da desigualdade nacional e de seu ainda vigente poder colonial, ou se é apenas uma válvula de escape para as frustrações políticas, oferecendo um momento catártico muito pontual aos espectadores.
AGROFORESTRY PATTERNS OF THE COMMUNITY IN BAKUBAKULU VILLAGE, PALOLO DISTRICT, SIGI REGENCY
Authors: Rachman Imran
Published: January 2022

The community in Bakubakulu Village, Palolo District, Sigi Regency, is one of the communities developing an agroforestry system. This study aims to determine the pattern of agroforestry used on community land in Bakubakulu Village. The study was carried out for three months, from October to December 2019. Respondents in this study used the purposive sampling technique intentionally (not randomly) according to the criteria. Data were analyzed using the descriptive method. The study results indicated that the agroforestry pattern applied by the respondents according to the time dimension is intermittent on sloping land and coincident on flat land. According to the spatial aspect, the pattern used by the respondents is regular temporarily on flat land and permanently random on sloping land. The plants planted mainly by the community are candlenut, sugar palm, cocoa, cloves, and coconut. Regular temporal pattern is the pattern most applied by respondents.
GLOBAL (NUTMEG IN SHELL) TRADING: TRADE AND INTEGRATION OF INTERNATIONAL MARKET
Authors: Maswadi Maswadi
Published: January 2022

The role of nutmeg in traditional and international trade is very significant because it is able to supply around 60-75 percent of the world's market share needs. The government as one of the market players has a role in creating strategic agricultural product price stabilization, and while there are still weaknesses of the agribusiness structure prevailing in Indonesia, integration analysis is very important given the benefits of knowledge about market integration. Market integration is useful to facilitate monitoring of price changes and support government policies on price stabilization and predict prices in the domestic market. Analysis of the market integration of this research uses the Vector Autoregression (VAR) model in difference determined through data stationarity test. Meanwhile, to determine the impact of the response of each variable due to shock (impulse response analysis) and Variance Decomposition. This research has three equations in the VAR analysis model and the results are all significant. The benefit of this research is to help determine the forecast of nutmeg prices in the domestic market and the impact of the response of each variable due to shocks.
The impact of experience and age of board members on profitability and efficiency: Evidence from state enterprises and parastatals in emerging markets
Authors: Maibvisira Gabriel , Muregwi Hapson Nyasha , Mutambara Emmanuel
Published: January 2022

Chiri (2017) described Zimbabwe’s state enterprises and parastatals (SEPs) as a burden to the fiscus. The article seeks to determine the effect of board member experience and age on profitability and efficiency of SEPs, respectively, as there has been little research, particularly in emerging markets. A positivist paradigm was adopted using a cross-sectional survey. The target population of the study consisted of all SEPs totalling 107 from which a sample of 20 SEPs was selected from the clusters using the simple random sampling technique. The Likert scale questionnaire was administered to respondents from the line ministry and targeted SEPs. The categorical principal component analysis was used as the main data analysis method. The value from Kaiser–Meyer–Olkin (KMO) and Bartlett’s test of sphericity and Cronbach’s alpha proved that the data obtained from the sample was adequate and reliable. A simple ANOVA conducted obtained a significance value of 0.000 leading to acceptance of both hypotheses because of p-value (0.000) < 0.001. The article concludes that board experience is a critical determinant of profitability and a positive relationship between the age of board members and SEPs efficiency exists. A policy framework on diversity in experience and age of board members should be enforced. The study is critical since SEPs occupy strategic sectors of the economy yet their contribution to gross domestic product continued to drop (World Bank, 2017).
Like A Rolling Stone
Authors: Stephen Edward Bottomley
Published: January 2022

Like a Rolling Stone was an international workshop and exhibition exploring the themes of relocation, transplantation, camouflage, identity and materiality through mixed media art jewellery. Geology and geophysics were examined as an analogy for the theme of population displacement.

In 2016 the Italian Cultural Institute (ICI) approached the department of Jewellery and Silversmithing, Edinburgh College of Art /The University of Edinburgh with a view to organising a series of events focusing on and celebrating gemmology and contemporary jewellery.
Stephen Bottomley + Susan Cross invited three Italian Jewellery artists: Maria Rosa Franzin, Gigi Mariani and Gabi Viet alongside seven UK based artists, Jessamy Kelly, Rhona McCallum, Jo Pudelko, Jessica Turrell and Cristina Zani, to undertake field work in North Berwick, an area frequently visited by the Geologist James Hutton, as a backdrop to the political themes surrounding population displacement.

Over the year following the Edinburgh workshop the project was developed in the artists home countries and exhibited in Munich and Edinburgh over 2018 with support from the School of Jewellery, Birmingham City University.
The exhibition is intended to tour later in 2021.
Inoperable poorly differentiated SCC to vertex of scalp progressing into sagittal sinus treated with palliative Cemiplimab
Authors: Grounds Katie , Emmanuel Odega
Published: January 2022

Cutaneous squamous cell carcinoma (cSCC) is the second most common non
melanoma skin cancer after Basal cell carcinoma, characterised by the
malignant proliferation of epidermal keratinocytes. We report a case of
an inoperable cSCC of the scalp extending into the sagittal sinus, now
responding well to the monoclonal antibody Cemiplimab.
Does age play a role in fever and neutropenia events and complications: A comparison of adolescents versus younger children with cancer at a tertiary care pediatric hospital, a pilot project
Authors: Kirolos Nardin , Tang Kenneth , Abbott Lesleigh
Published: January 2022

Background: Adolescents and young adults with cancer (AYA) are a complex
group of patients. The development of fever and neutropenia (FN) is a
potentially lethal complication of chemotherapy. Risk stratification of
patients with FN has become increasingly valuable allowing for early
intervention and for the use of lower intensity treatments. There are
risk stratification guidelines that exist, but most are validated in
young children with cancer (YCWC). AYA are frequently shown to have more
numerous and severe side effects from chemotherapy. This study aimed to
identify whether age contributes to the incidence and severity of FN.
Procedure: Patients diagnosed with a malignancy in a 5-year period at
our institution were included from ages 0-18 yrs. We reviewed details of
their FN events, including duration of hospital admission, source
(bacterial/fungal), PICU admission and duration, positive blood cultures
and mortality. Results: Adolescents with cancer (AWC) had a trend of
being 1.56 times more likely to have FN events (CI 95% 0.936-2.622,
p=0.087). Assessment of the duration of PICU stay showed that AWC were
4.9 times more likely to have longer admissions (CI 95% 0.998-24.067,
p=0.050). There was no significant difference between the two groups in
the rate of PICU admission, positive cultures, identification of a
bacterial or fungal source, hospital admission duration or mortality.
Conclusions: This study demonstrated a trend towards AWC being more
likely to develop FN events. When such events occur in this group, the
severity of them may be heightened as evidenced by longer duration of
PICU admission.
Leukaemia Cutis: Clinical Features and Outcomes of 56 Patients
Authors: Yook Hwa Jung , Son Joon Ho , Kim Yeong Ho , Han Ju Hee , Lee Ji Hyun , Park Young Min , Chung Nack-Gyun , Kim Hee Je , Bang Chul Hwan
Published: January 2022

Leukaemia is a malignant neoplasm of the haematopoietic system. Cutaneous manifestations of leukaemia are called leukaemia cutis, and are regarded as a sign of poorer prognosis and shorter survival time. A single-institution retrospective review was performed of medical records of patients diagnosed with leukaemia cutis in the dermatology department of Seoul St Mary’s Hospital between January 2012 and April 2021. Fifty-six cases with cutaneous leukaemic involvement and underlying haematological malignancy were included (40 acute myelogenous leukaemia, 8 acute lymphoblastic leukaemia, 3 chronic myeloid leukaemia, 2 chronic lymphocytic leukaemia, and 3 myelodysplastic syndrome). Male-female ratio 1.9:1, mean age at diagnosis 45.8 years. Plaques (28%) and papules (27%) were the most common skin lesions, followed by patches (18%) and nodules (16%). Mean time from diagnosis of leukaemia to development of leukaemia cutis was 12.3 months. Forty-six patients (84%) died during the 7-year follow-up; mean time from diagnosis of leukaemia cutis to death was 5.4 months. The results suggest that leukaemia cutis is associated with poor outcomes in patients with leukaemia. Comprehensive skin examination of these patients may help diagnose leukaemia cutis early, enabling prompt treatment.
Global Risk of Bacterial Skin Infections and Herpesviridae Infections with Ustekinumab, Secukinumab, and Tumour Necrosis Factor-alpha Inhibitors: Spontaneous Reports of Adverse Drug Reactions from the World Health Organization Pharmacovigilance Center
Authors: Davidson Linda , Van den Reek Juul M.P.A. , Van Hunsel Florence , De Jong Elke M.G.J. , Kullberg Bart Jan
Published: January 2022

Genetic defects in interleukin-12/23/17 immunity are associated with an increased risk of Staphylococcus aureus and herpesvirus skin infections. This study analysed spontaneous safety reports from the WHO Pharmacovigilance Center of bacterial skin or herpesvirus infections associated with secukinumab, ustekinumab and tumour necrosis factor-α inhibitors. Associations found in disproportionality analyses were expressed as reporting odds ratios (ROR). For bacterial skin infections, ustekinumab showed the strongest association (ROR 6.09; 95% confidence interval (95% CI) 5.44–6.81), and, among the tumour necrosis factor-α inhibitors, infliximab showed the strongest association (ROR 4.18; 95% CI 3.97–4.40). Risk was comparable between infliximab and secukinumab (ROR 3.51; 95% CI 3.00–4.09). Secukinumab showed the strongest association with herpes simplex infection (ROR 4.80; 95% CI 3.78–6.10). All biologics were equally associated with herpes zoster. Infliximab was the only biologic associated with cytomegalovirus infection (ROR 5.66; 95% CI 5.08–6.31) and had the strongest association with Epstein-Barr virus infection (ROR 6.90; 95% CI 6.03–7.90). All biologics evaluated were positively associated with bacterial skin infections, herpes simplex, and herpes zoster, compared with all other drugs in the WHO database for which individual case safety reports were collected. The possibility of under-reporting, reporting bias and difference in causality assessment between countries and reporters must be taken into account when interpreting the results of disproportionality analyses.
PLASTIC MULCHING OR CONVENTIONAL CULTIVATION OF LAVENDER FLOWER: WHAT INFLUENCE ON THE YIELD, ESSENTIAL OIL AND THEIR NEUROPROTECTIVE EFFECTS?
Authors: ŞEKEROĞLU Nazım , CİMEN Gulfer , KULAK Muhittin , GEZİCİ Sevgi
Published: January 2022

Lavender (Lavandula angustifolia Mill.) flowers and its distilled products are of major raw materials for cosmetic, perfumery, medicine and cleaning industries. Lavender flower production, essential oils and their qualities are affected by growing conditions and used agricultural methods. Mulching is a cultural application used for horticultural production in order to combat weeds, keep the soil temperature constant, eliminate soil moisture evaporation, provide favourable growth conditions for ample flower production, and improve the quality essential oil production. In this sense, plastic mulch application is the mainly preferred method by the growers, due to its low costs and durability. In the present study, two-year field (2014-2015) studies were carried out to evaluate the lavender flower production, essential oil yield in both conventional (without mulch) and plastic mulching systems in city of Kilis-Turkey. The individual essential oil compounds were identified using Gas Chromatography-Mass Spectrometer (GC-MS). Essential oils obtained from dried flowers were assayed for their neuroprotective effects. According to the results, fresh and dry inflorescence yields, dry flower yields, flower essential oil contents and compositions were affected by different growing methods, including (1) plastic mulching system and (2) conventional (without mulch) system. Considering the fresh inflorescence changes, mulching increased the yield by 147.84% in the first year while no significant changes were noted between treatments. Interestingly, dry inflorescence yield did not show a significant increase for both growing systems at first year but mulching enhanced the yield by 9.87% in the second year, in related to the traditional treatment. The results revealed that dry flower was not affected by both growing systems corresponding to the years. As for essential oil content, no changes were noted for both growing systems in the first year, whilst mulching increased the content by 13.73% in the second year. As the case of agricultural yield, the neuroprotective activities of essential oils obtained from mulching conditions exerted higher inhibitory roles against Acetyl-cholinesterase (AChE), butyryl-cholinesterase (BChE), and tyrosinase (TYRO) enzymes, in relative to the traditional treatments by 81.62%, 84.12%, 73.34% in the first year and by 76.15%, 79.80% and 68.02% in the second year. Such a high variation in neuroprotective activities can be explained by changes in essential oil contents, as observed for the percentage of the compounds. Consequently, these findings reveal that mulching application significantly contributes to the increase of agricultural yield and the growing of medicinal and aromatic plants that are more resistant to changing environmental conditions and biotic stress factors.
MODELAGEM MATEMÁTICA
Authors: Silva Lorenna Gondim , Felicio Cinthia Maria , Ferreira Julio Cesar
Published: January 2022

Esta pesquisa relata a aplicação de uma sequência didática sobre o conteúdo de função quadrática utilizando o método da modelagem matemática no contexto das metodologias ativas. O objetivo deste trabalho é desenvolver uma sequência didática baseada nos conceitos de modelagem matemática e avaliar suas contribuições no ensino de função quadrática de uma instituição de ensino especializada em cursos de Educação Profissional e Tecnológica no interior do estado de Goiás. Esta pesquisa é do tipo descritiva de abordagem qualitativa com estudo de caso, onde a avaliação é feita com base nas contribuições da modelagem matemática para o ensino de função quadrática e a pela aceitação desse método proposto. Os resultados revelaram que a modelagem matemática proporcionou aos educandos contextualização do conteúdo a partir de modelos encontrados no cotidiano, favoreceu a fixação do conteúdo de função quadrática, bem como possibilitou a formação de cidadãos críticos e participativos. Foi possível perceber que a modelagem matemática pode ser um método que estimula o estudante a criar, comparar, discutir, perguntar, visualizar e ampliar os conhecimentos. Assim, faz-se necessária a inserção de atividades cooperativas e dinamizadas para a conquista da autonomia e da aprendizagem pelos estudantes.