bluuebunny/crossref_metadata_2025 huggingface dataset:
A Heuristic Projection Pursuit Method Based on a Connection Cloud Model and Set Pair Analysis for Evaluation of Slope Stability
Authors: Wang Mingwu , Wang Yan , Shen Fengqiang , Jin Juliang
Published: October 2021

Determining the projection direction vector (PDV) is essential to the projection pursuit evaluation method for high-dimensional problems under multiple uncertainties. Although the PP method using a cloud model can facilitate interpretation of the fuzziness and randomness of the PDV, it ignores the asymmetry of the PDV and the fact that indicators are actually distributed over finite intervals; it quickly falls into premature defects. Therefore, a novel PP evaluation method based on the connection cloud model (CCM) is discussed to remedy these drawbacks. In this approach, adaptive numerical characteristics of the CCM are adopted to represent the randomness and fuzziness of the candidate PDV and evaluation indicators. Meanwhile, to avoid complex computing and to accelerate the convergence speed of the optimization procedure, an improved fruit fly optimization algorithm (FOA) is set up to find the rational PDV. Alternatively, candidate PDVs are mutated based on the mechanism “pick the best of the best” using set pair analysis (SPA) and chaos theory. Furthermore, the applicability and reliability are discussed based on an illustrative example of slope stability evaluation and comparisons with the neural network method and the PP evaluation method based on the other FOAs and the genetic algorithm. Results indicate that the proposed method with simpler code and quicker convergence speed has good global ergodicity and local searching capabilities, and can better explore the structure of high-dimensional data with multiple uncertainties and asymmetry of the PDV relative to other methods.
Vortical Effects for Free Fermions on Anti-De Sitter Space-Time
Authors: Ambrus Victor E. , Winstanley Elizabeth
Published: October 2021

Here, we study a quantum fermion field in rigid rotation at finite temperature on anti-de Sitter space. We assume that the rotation rate Ω is smaller than the inverse radius of curvature ℓ−1, so that there is no speed of light surface and the static (maximally-symmetric) and rotating vacua coincide. This assumption enables us to follow a geometric approach employing a closed-form expression for the vacuum two-point function, which can then be used to compute thermal expectation values (t.e.v.s). In the high temperature regime, we find a perfect analogy with known results on Minkowski space-time, uncovering curvature effects in the form of extra terms involving the Ricci scalar R. The axial vortical effect is validated and the axial flux through two-dimensional slices is found to escape to infinity for massless fermions, while for massive fermions, it is completely converted into the pseudoscalar density −iψ¯γ5ψ. Finally, we discuss volumetric properties such as the total scalar condensate and the total energy within the space-time and show that they diverge as [1−ℓ2Ω2]−1 in the limit Ω→ℓ−1.
Fast and Reliable Determination of Phthalic Acid Esters in the Blood of Marine Turtles by Means of Solid Phase Extraction Coupled with Gas Chromatography-Ion Trap/Mass Spectrometry
Authors: Notardonato Ivan , Di Fiore Cristina , Iannone Alessia , Russo Mario Vincenzo , Blasi Monica Francesca , Favero Gabriele , Mattei Daniela , Protano Carmela , Vitali Matteo , Avino Pasquale
Published: October 2021

The presence of phthalic acid esters (PAEs) in marine environments is an important issue. These chemicals are able to affect marine organisms, particularly marine turtles, and to act as endocrine disrupters. In this paper, for the first time, a simple and reproducible analytical method based on solid-phase extraction (SPE) coupled with gas chromatography—ion trap/mass spectrometry (GC-IT/MS) was developed for the extraction of phthalates from the blood of marine turtles. The extraction was obtained by using C18 phthalates-free as the stationary phase. In order to individuate the best working conditions for the extraction, the adsorption isotherms and breakthrough curves were studied. The overall analytical methodology was validated in terms of limit of detection (LOD, 0.08–0.6 ng mL−1), limit of quantification (LOQ, 0.4–0.8 ng mL−1), and correlation coefficients (>0.9933). By using this procedure, percentage recoveries ranging from 89 to 103% were achieved. The precision parameters (intra-day and inter-day) were studied, and the obtained values were smaller than 12.5%. These data confirm the goodness of the proposed analytical methodology, which is applied to real samples.
The Effects of Ferric Sulfate (Fe2(SO4)3) on the Removal of Cyanobacteria and Cyanotoxins: A Mesocosm Experiment
Authors: Le Kim Thien Nguyen , Goitom Eyerusalem , Trigui Hana , Sauvé Sébastien , Prévost Michèle , Dorner Sarah
Published: October 2021

Cyanobacterial blooms are a global concern. Chemical coagulants are used in water treatment to remove contaminants from the water column and could potentially be used in lakes and reservoirs. The aims of this study was to: 1) assess the efficiency of ferric sulfate (Fe2(SO4)3) coagulant in removing harmful cyanobacterial cells from lake water with cyanobacterial blooms on a short time scale, 2) determine whether some species of cyanobacteria can be selectively removed, and 3) determine the differential impact of coagulants on intra- and extra-cellular toxins. Our main results are: (i) more than 96% and 51% of total cyanobacterial cells were removed in mesocosms with applied doses of 35 mgFe/L and 20 mgFe/L, respectively. Significant differences in removing total cyanobacterial cells and several dominant cyanobacteria species were observed between the two applied doses; (ii) twelve microcystins, anatotoxin-a (ANA-a), cylindrospermopsin (CYN), anabaenopeptin A (APA) and anabaenopeptin B (APB) were identified. Ferric sulfate effectively removed the total intracellular microcystins (greater than 97% for both applied doses). Significant removal of extracellular toxins was not observed after coagulation with both doses. Indeed, the occasional increase in extracellular toxin concentration may be related to cells lysis during the coagulation process. No significant differential impact of dosages on intra- and extra-cellular toxin removal was observed which could be relevant to source water applications where optimal dosing is difficult to achieve.
Identification of Shiga-Toxin-Producing Shigella Infections in Travel and Non-Travel Related Cases in Alberta, Canada
Authors: Zhi Shuai , Parsons Brendon D. , Szelewicki Jonas , Yuen Yue T. K. , Fach Patrick , Delannoy Sabine , Li Vincent , Ferrato Christina , Freedman Stephen B. , Lee Bonita E. , Pang Xiao-Li , Chui Linda
Published: October 2021

It has long been accepted that Shiga toxin (Stx) only exists in Shigella dysenteriae serotype 1. However, in recent decades, the presence of Shiga toxin genes (stx) in other Shigella spp. have been reported. We screened 366 Shigella flexneri strains from Alberta, Canada (2003 to 2016) for stx and 26 positive strains were identified. These isolates are highly related with the majority originating from the Dominican Republic and three isolates with Haiti origin. Both phylogenetic and spanning tree analysis of the 26 Alberta and 29 stx positive S. flexneri originating from the U.S., France, Canada (Quebec) and Haiti suggests that there are geographic specific distribution patterns (Haiti and Dominican Republic clades). This study provides the first comprehensive whole genome based phylogenetic analysis of stx positive S. flexneri strains as well as their global transmission, which signify the public health risks of global spreading of these strains.
The Intriguing Conundrum of a Nonconserved Multifunctional Protein of Citrus Tristeza Virus That Interacts with a Viral Long Non-Coding RNA
Authors: Kang Sung-Hwan , Aknadibossian Vicken , Kharel Laxmi , Mudiyanselage Shachinthaka D. Dissanayaka , Wang Ying , Folimonova Svetlana Y.
Published: October 2021

Citrus tristeza virus (CTV), the largest non-segmented plant RNA virus, has several peculiar features, among which is the production of a 5′-terminal long non-coding RNA (lncRNA) termed low-molecular-weight tristeza 1 (LMT1). In this study, we found that p33, a unique viral protein that performs multiple functions in the virus infection cycle, specifically binds LMT1, both in vivo and in vitro. These results were obtained through the expression of p33 under the context of the wild type virus infection or along with a mutant CTV variant that does not produce LMT1 as well as via ectopic co-expression of p33 with LMT1 in Nicotiana benthamiana leaves followed by RNA immunoprecipitation and rapid amplification of cDNA ends assays. Further experiments in which a recombinant p33 protein and an in vitro transcribed full-length LMT1 RNA or its truncated fragments were subjected to an electrophoretic mobility shift assay demonstrated that p33 binds to at least two distinct regions within LMT1. To the best of our knowledge, this is the first report of a plant virus protein binding to a lncRNA produced by the same virus. The biological significance of the interaction between these two viral factors is discussed.
Identification and Genetic Characterization of Viral Pathogens in Ruminant Gestation Abnormalities, Israel, 2015–2019
Authors: Golender Natalia , Bumbarov Velizar , Kovtunenko Anita , David Dan , Guini-Rubinstein Marisol , Sol Asaf , Beer Martin , Eldar Avi , Wernike Kerstin
Published: October 2021

Infectious agents including viruses are important abortifacients and can cause fetal abnormalities in livestock animals. Here, samples that had been collected in Israel from aborted or malformed ruminant fetuses between 2015 and 2019 were investigated for the presence of the following viruses: the reoviruses bluetongue virus (BTV) and epizootic hemorrhagic disease virus (EHDV), the flaviviruses bovine viral diarrhea virus (BVDV) and border disease virus (BDV), the peribunyaviruses Shuni virus (SHUV) and Akabane virus (AKAV), bovine herpesvirus type 1 (BoHV-1) and bovine ephemeral fever virus (BEFV). Domestic (cattle, sheep, goat) and wild/zoo ruminants were included in the study. The presence of viral nucleic acid or antigen could be confirmed in 21.8 % of abnormal pregnancies (213 out of 976 investigated cases), with peribunyaviruses, reoviruses and pestiviruses being the most prevalent. At least four different BTV serotypes were involved in abnormal courses of pregnancy in Israel. The subtyping of pestiviruses revealed the presence of two BDV and several distinct BVDV type 1 strains. The peribunyaviruses AKAV and SHUV were identified annually throughout the study period, however, variation in the extent of virus circulation could be observed between the years. In 2018, AKAV even represented the most detected pathogen in cases of small domestic ruminant gestation abnormalities. In conclusion, it was shown that various viruses are involved in abnormal courses of pregnancy in ruminants in Israel.
Equine Arteritis Virus (EAV) Outbreak in a Show Stallion Population
Authors: Otzdorff Christiane , Beckmann Julia , Goehring Lutz S.
Published: October 2021

(1) Background: Equine arteritis virus (EAV) infection causes reproductive losses and systemic vasculitis in susceptible equidae. The intact male becomes the virus’ reservoir upon EAV infection, as it causes a chronic-persistent infection of the accessory sex glands. Infected semen is the main source of virus transmission. (2) Here, we describe acute EAV infection and spread in a stallion population after introduction of new members to the group. (3) Conclusions: acute clinical signs, acute phase detection of antigen via (PCR) nasal swabs or (EDTA) blood, and seroconversion support the idea of transmission via seminal fluids into the respiratory tract(s) of others. This outbreak highlights EAV’s horizontal transmission via the respiratory tract. This route should be considered in a chronic-persistently infected herd, when seronegative animals are added to the group.
First Genomic Evidence of Dual African Swine Fever Virus Infection: Case Report from Recent and Historical Outbreaks in Sardinia
Authors: Fiori Mariangela Stefania , Ferretti Luca , Floris Matteo , Loi Federica , Nardo Antonello Di , Sechi Anna Maria , Ladu Anna , Puggioni Graziella , Sanna Daria , Scarpa Fabio , Sanna Maria Luisa , Madrau Maria Paola , Torresi Claudia , Sirica Roberto , Evangelista Eloisa , Oggiano Annalisa , Dei Giudici Silvia
Published: October 2021

African swine fever virus (ASFV) is one of the pathogens of highest concern worldwide. Despite different virus lineages co-circulating in several areas, dual infections in the same animal have been rarely observed, suggesting that ASF superinfections are infrequent events. Here we present the first genome-wide detection and analysis of two intragenotype dual ASFV infections. The dual infections have been detected in a hunted wild boar and in a pig carcass, both infected by ASFV genotype I in Sardinia in 1984 and 2018, respectively. We characterize the genetic differences between the two sequences, their intra-host frequency, and their phylogenetic relationship among fully sequenced ASFV strains from Sardinia. Both dual infections involve pairs of closely related but different viruses that were circulating in Sardinia in the same period. The results imply that dual ASFV infections or similar ASFV strains are more common than expected, especially in ASF endemic areas, albeit difficult to detect.
Chimeric Vaccines Based on Novel Insect-Specific Flaviviruses
Authors: Harrison Jessica J. , Hobson-Peters Jody , Bielefeldt-Ohmann Helle , Hall Roy A.
Published: October 2021

Vector-borne flaviviruses are responsible for nearly half a billion human infections worldwide each year, resulting in millions of cases of debilitating and severe diseases and approximately 115,000 deaths. While approved vaccines are available for some of these viruses, the ongoing efficacy, safety and supply of these vaccines are still a significant problem. New technologies that address these issues and ideally allow for the safe and economical manufacture of vaccines in resource-poor countries where flavivirus vaccines are in most demand are urgently required. Preferably a new vaccine platform would be broadly applicable to all flavivirus diseases and provide new candidate vaccines for those diseases not yet covered, as well as the flexibility to rapidly pivot to respond to newly emerged flavivirus diseases. Here, we review studies conducted on novel chimeric vaccines derived from insect-specific flaviviruses that provide a potentially safe and simple system to produce highly effective vaccines against a broad spectrum of flavivirus diseases.
Comprehensive Regulation Benefits of Hydropower Generation System in Reducing Wind Power Fluctuation
Authors: Xu Beibei , Zhang Jingjing , Yuan Shuai , Li Huanhuan , Chen Diyi , Zhang Junzhi
Published: October 2021

The use of renewable energy has become a necessity to generate electricity, and is taking the place of conventional coal-fired power, as it has clear economic and environmental benefits. The purpose of this paper is to quantify the comprehensive benefits of hydropower in reducing wind power fluctuation in a hybrid coal-fired/hydro/wind power system. To achieve this, a wind–hydropower generation system must be established, and its complementary characteristic is also illustrated based on the resultant wind speed. Then, based on Institute of Electrical and Electronics Engineers (IEEE) 14 Bus Power System, coal-fired generation is introduced to model a final hybrid integrated power system. The comprehensive benefit evaluation method, including the power consumption profit, the peak load profit, the energy conservation profit, the guide vane fatigue cost, the maintenance cost, and the start-stop cost, is presented to assess the join operation benefits of the wind/hydropower/coal-fired integrated system. The complementary investigation shows that the hydropower system has an excellent effect on suppressing wind power fluctuation, although the fatigue damage of hydraulic guide vanes is a little severe for the time scale of hours, compared with that of seconds. The quantified benefit shows that the increased power consumption profit, the increased guide vane fatigue loss cost, the decreased peak-load profit, and the increased energy conservation profit are RMB 1262.43 million/year, RMB 0.37 million/year, RMB 333.97 million/year and RMB 0.54 million/year, with the wind and hydropower ratio increasing from 16% to 25%, which directly leads to the annual total revenue increasing to RMB 143.2673 million. The implementation of this paper can contribute to making more efficient use of wind-hydro power in conventional electricity production.
Role of GPs in shared decision making with patients about palliative cancer treatment: a qualitative study in the Netherlands
Authors: Hoek Danique W Bos-van den , van der Velden Naomi CA , Huisman Rozemarijn , van Laarhoven Hanneke WM , Tange Dorien , Wind Jan , Smets Ellen MA , Henselmans Inge
Published: October 2021

Background

GPs are well placed to enhance shared decision making (SDM) about treatment for patients with advanced cancer. However, to date, little is known about GPs’ views about their contribution to SDM.

Aim

To explore GPs’ perspectives on their role in SDM about palliative cancer treatment and the requirements they report to fulfil this role.

Design and setting

Qualitative interview study among Dutch GPs.

Method

GPs were sampled purposefully and conveniently. In-depth, semi-structured interviews were conducted, recorded, and transcribed verbatim. Transcripts were analysed by thematic analysis.

Results

Fifteen GPs took part in this study. Most of them reported practices that potentially support SDM: checking the quality of a decision, complementing SDM, and enabling SDM. Even though most of the GPs believed that decision making about systemic cancer treatment is primarily the oncologist’s responsibility, they did recognise their added value in the SDM process because of their gatekeeper position, the additional opportunity they offer patients to discuss treatment decisions, and their knowledge and experience as primary healthcare providers at the end of life. Requirements for them to support the SDM process were described as: good collaboration with oncologists; sufficient information about the disease and its treatment; time to engage in conversations about treatment; a trusting relationship with patients; and patient-centred communication.

Conclusion

GPs may support SDM by checking the quality of a decision and by complementing and enabling the SDM process to reach high-quality decisions. This conceptualisation of the GP’s supporting role in SDM may help us to understand how SDM is carried out through interprofessional collaboration and provide tools for how to adopt a role in the interprofessional SDM process.
The Impact of Control Measures and Holiday Seasons on Incidence and Mortality Rate of COVID-19 in Iran
Authors: Haji-Maghsoudi Saiedeh , Sadeghifar Majid , Roshanaei Ghodratollah , Mahjub Hossein
Published: October 2021

Background: Preventive measures on the COVID-19 pandemic is an effective way to control its spread. We aimed to investigate the effect of control measures and holiday seasons on the incidence and mortality rate of COVID-19 in Iran. Study design: An observational study. Methods: The daily data of confirmed new cases and deaths in Iran were taken from the Johns Hopkins University COVID-19 database. We calculated weekly data from 19 Feb to 6 Oct 2020. To estimate the impact of control measures and holiday seasons on the incidence rate of new cases and deaths, an autoregressive hidden Markov model (ARHMM) with two hidden states fitted the data. The hidden states of the fitted model can distinguish the peak period from the non-peak period. Results: The control measures with a delay of one-week and two-week had a decreasing effect on the new cases in the peak and non-peak periods, respectively (P=0.005). The holiday season with a two-week delay increased the total number of new cases in the peak periods (P=0.031). The peak period for the occurrence of COVID-19 was estimated at 3 weeks. In the peak period of mortality, the control measures with a three-week delay decreased the COVID-19 mortality (P=0.010). The expected duration of staying in the peak period of mortality was around 6 weeks. Conclusions: When an increasing trend was seen in the country, the control measures could decline the incidence and mortality related to COVID-19. Implementation of official restrictions on holiday seasons could prevent an upward trend of incidence for COVID-19 during the peak period.
Iran COVID-19 Epidemiology Committee: A Review of Missions, Structures, Achievements, and Challenges
Authors: Amiri Shahin , Haghdoost Aliakbar , Mostafavi Ehsan , Sharifi Hamid , Peykari Niloofar , Raeisi Ahmad , Assai Ardakani Mohammad , Asadi Lari Mohsen , Soori Hamid , Ostovar Afshin , Eshrati Babak , Gouya Mohammad Mehdi , Nasehi Mahshid , Tabatabaei Seyed Mehdi , Amirkhani Manzar , Eybpoosh Sana
Published: October 2021

Background: Since the beginning of the coronavirus disease 2019 (COVID-19) epidemic in Iran, the control and management of the epidemic were headed by the National Headquarter for the Control of COVID-19 Epidemic through setting up different scientific committees, including the COVID-19 National Epidemiology Committee. The present study reviews the missions, structures, achievements, and challenges of the Epidemiology Committee. Study design: A rapid review Methods: All relevant reports, documents, guidelines, published literature, and surveillance data related to the establishment, visions, missions, roles, activities, and outputs of the COVID-19 Epidemiology Committee were critically reviewed in this study. Results: The efforts of the committee’s working groups may have impacted improvements in data registration/usage, provincial data quality at provincial levels, and perception of the epidemic situation in the provinces. The committees have also played role in informing the policies in different stages of the epidemic through routine or problem-based data/evidence analyses, epidemic investigations, and mathematical modeling. Conclusions: The structure and experience gained by the committee can be used in similar situations within and outside the country. To further improve the impacts of our activities, it is essential to have effective interaction, collaboration, and data flow between the committee and a broad range of organizations within and outside the Ministry of Health and Medical Education.
Predictive Role of Population Density and Use of Public Transport for Major Outcomes of SARS-CoV-2 Infection in the Italian Population: An Ecological Study
Authors: Ilardi Alfonso , Chieffi Sergio , Ilardi Ciro Rosario
Published: October 2021

Background: This study aimed at assessing how population density (PD), aging index (AI), use of public transport (URPT), and PM10 concentration (PI) modulated the trajectory of the main COVID-19 pandemic outcomes in Italy, also in the recrudescence phase of the epidemic. Study design: Ecological study. Methods: For each region, we recovered data about cases, deaths, and case fatality rate (CFR) recorded since both the beginning of the epidemic and September 1, 2020. Data about total hospitalizations were included as well. Results: PD correlated with, and was the best predictor of, total and partial cases, total and partial deaths, and total hospitalizations. Moreover, URPT correlated with, and was the best predictor of, total CFR. Besides, PI correlated significantly with total and partial cases, total and partial deaths, and total hospitalizations. Conclusions: PD explains COVID-19 morbidity, mortality, and severity while URPT is the best predictor of disease lethality. These findings should be interpreted with caution due to the ecological fallacy.
Survival Rates and Prognostic Factors in Patients with Coronavirus Disease 2019: A Registry-Based Retrospective Cohort Study
Authors: Shahbazi Fatemeh , Karami Manoochehr , Mirzaei Mohammad , Mohammadi Younes
Published: October 2021

Background: Coronavirus disease 2019 (COVID-19) is a contagious disease caused by a newly identified coronavirus. Our knowledge about the survival rate and prognostic factors of the disease is not established well. Therefore, this study aimed to identify the risk factors associated with the survival of COVID-19 cases in Hamadan province, West of Iran. Study design: A retrospective cohort study Methods: This retrospective cohort study was performed in Hamadan province, West of Iran. The study included patients that referred to the provincial hospitals from February 20 to September 20, 2020. The follow-up of each subject was calculated from the date of onset of respiratory symptoms to the date of death. Demographic and clinical characteristics were extracted from patients’ medical records. Kaplan-Meier method, Flemington-Harrington test, and Cox regression were used for data analysis. Results: The overall 1, 5, 10, 20, 30 and 49-day survival rates were estimated at 99.57%, 95.61%, 91.15%, 87.34%, 86.91%, and 86.74%, respectively. Furthermore, survival time showed a significant association with age, gender, history of traveling to contaminated areas, co-morbidity, neoplasms, chronic diseases, and hospital units. Conclusions: In conclusion, elderly people, male gender, and comorbidities presented a greater risk of death. Therefore, it is important to pay more attention to this group of people to reduce the incidence and consequences after infection.
Nine-month Trend of Time-Varying Reproduction Numbers of COVID-19 in West of Iran
Authors: Rahimi Ebrahim , Hashemi Nazari Seyed Saeed , Mokhayeri Yaser , Sharhani Asaad , Mohammadi Rasool
Published: October 2021

Background: The basic reproduction number (R0) is an important concept in infectious disease epidemiology and the most important parameter to determine the transmissibility of a pathogen. This study aimed to estimate the nine-month trend of time-varying R of COVID-19 epidemic using the serial interval (SI) and Markov Chain Monte Carlo in Lorestan, west of Iran. Study design: Descriptive study. Methods: This study was conducted based on a cross-sectional method. The SI distribution was extracted from data and log-normal, Weibull, and Gamma models were fitted. The estimation of time-varying R0, a likelihood-based model was applied, which uses pairs of cases to estimate relative likelihood. Results: In this study, Rt was estimated for SI 7-day and 14-day time-lapses from 27 February-14 November 2020. To check the robustness of the R0 estimations, sensitivity analysis was performed using different SI distributions to estimate the reproduction number in 7-day and 14-day time-lapses. The R0 ranged from 0.56 to 4.97 and 0.76 to 2.47 for 7-day and 14-day time-lapses. The doubling time was estimated to be 75.51 days (95% CI: 70.41, 81.41). Conclusions: Low R0 of COVID-19 in some periods in Lorestan, west of Iran, could be an indication of preventive interventions, namely quarantine and isolation. To control the spread of the disease, the reproduction number should be reduced by decreasing the transmission and contact rates and shortening the infectious period.
Evaluation of the Factors Affecting the Cure Rate of Cervical Intra-Epithelial Neoplasia Recurrence Using Defective Models
Authors: Hajizadeh Nastaran , Baghestani Ahmad Reza , Pourhoseingholi Mohamad Amin , Khadem Maboudi Ali Akbar , Farzaneh Farah , Faghih Nafiseh
Published: October 2021

Background: Treatment of cervical intraepithelial neoplasia is very important since if it remains untreated, it may progress to cervical cancer. It is usually treated with excisional surgery. This study aimed to find the factors affecting the cure rate of cervical intraepithelial neoplasia recurrence after surgery using defective models. Study design: A retrospective cohort study. Methods: Excisional surgery was performed on 307 patients with high-grade cervical intraepithelial neoplasia, from 2009 to 2017. The patients were followed up until recurrence based on histopathology report. Hematologic factors were measured before surgery. The cure rates were estimated using defective models with a Gamma frailty term and the results were compared. Results: Neutrophil-to-lymphocyte ratio (NLR) (P<0.001) and excised mass size (P<0.001) had significant impacts on cure rates, and their cut-off values were 1.9 (P<0.001) and 15 mm2 (P<0.001), respectively. Patients with lower neutrophil-to-lymphocyte ratios and larger excised tissues had higher cure rates. Defective 3-parameter Gompertz distribution with gamma frailty term had the best fit to the data, and its estimated cure rates were 98% among patients with an excised mass size of >15 mm2 and NLR of <1.9, 84% among patients with an excised mass size of >15 mm2 and NLR of >1.9, 79% among patients with an excised mass size of <15 mm2 and NLR of <1.9, and 30% among patients with an excised mass size of <15 mm2 and NLR of >1.9. Conclusion: Cervical intraepithelial neoplasia must be identified and treated before its progress. Excision of more tissues during excisional surgery, especially when the NLR of the patient is high, can help to prevent cervical intraepithelial neoplasia recurrence.
Effects of Lifestyle and Environmental Factors on the Risk of Acute Myeloid Leukemia: Result of a Hospital-based Case-Control Study
Authors: Maleki Behzad Masumeh , Abbasi Mohammad , Oliaei Iman , Ghorbani Gholiabad Somayeh , Rafieemehr Hassan
Published: October 2021

Background: Acute myeloid leukemia (AML) is a common malignancy in adults. A vast variety of environmental and lifestyle factors play a role in AML incidence. This study aimed to assess the factors related to AML. Study design: A case-control study. Methods: This case-control study was performed on 137 AML cases during 2018-2021 at Beheshti Hospital in Hamadan, Iran, and 137 gender/age-matched controls. A questionnaire including 12 items was used to obtain information about lifestyle and environmental factors. A univariate and multiple variate logistic regression was used to estimate the odds ratios (OR), and a 95% confidence interval (CI) was used to investigate the relationship between the studied variables and the incidence of AML. Results: Based on findings, 62 (45.3%) out of the 137 leukemic cases were male and 75 (4.7%) were females. A statistically significant increased risk for AML was found with regard to prior usage of cytotoxic agents (OR: 8.00, 95% CI: 1.01, 63.9, P=0.050), family history of malignancies (OR: 3.62, 95% CI: 1.65, 7.92, P=0.001), exposure to electrical power (OR: 3.22, 95% CI: 1.52, 6.81, P=0.002), and history of mental diseases (OR: 8.50, 95% CI: 3.64, 19.80, P=0.001). It was found that the AML incidence had no association with age, gender, radiation therapy, cigarette smoking, prior chemotherapy, congenital disorders, exposure to chemical agents, history of infectious mononucleosis, exercise, and blood transfusion (P>0.05). Conclusion: The current results suggested that cytotoxic agents, family history of malignancy, mental disorders, and exposure to electrical power could play a role in AML incidence.
Rethinking How We Teach and Assess Reading Comprehension
Authors: Catts Hugh William
Published: October 2021

Reading comprehension is not a skill that can be easily assessed and taught but rather is a complex mental activity that relies heavily on background knowledge and higher-level cognitive functioning. This paper addresses the multifactorial nature of reading comprehension and the implications for instruction and assessment.
Tes Slominski, Trad Nation: Gender, Sexuality, and Race in Irish Traditional Music (2020)
Authors: Hanlon Ann-Marie
Published: October 2021

A review of Tes Slominski, Trad Nation: Gender, Sexuality, and Race in Irish Traditional Music (Middletown: Wesleyan University Press, 2020). ISBN 9780819579287, 244pp, £19.95 (Hardback).
Da vida marinha ao sentimento oceânico
Authors: Freitas Marta Helena de , Schmidt Bettina
Published: October 2021

Um reconhecido biólogo britânico, premiadíssimo por suas contribuições no estudo da vida marinha, imediatamente após se aposentar na Universidade de Oxford, no Reino Unido, aos 73 anos, passa a se dedicar integralmente ao estudo da vitalidade do fenômeno religioso, fundando uma Unidade de Pesquisa em Experiência Religiosa (RERU). Trata-se de Alister Hardy (1896-1985), cujas história, principais obras e concepções, influências recebidas e contribuições decorrentes para a Psicologia da Religião são focos deste artigo, de cunho teórico e historiográfico, escrito por ocasião dos 50 anos de fundação da referida unidade. Atualmente, situada em Lampeter, País de Gales, acolhida pela University of Wales Trinity University, desde 2000, recebe o nome de Alister Hardy Religious Experience Research Centre (RERC).
Integrated Blood Type Detector with IoT System to Improve Indonesian Red-Cross Public Health Services
Authors: Dennis, L Abu H. R, R. Setyo,
Published: October 2021

A survey held by the World Health Organization in 2008 shows that the bloodstock in Indonesia is 0.2% of the total population, which is lower than the minimum requirement for health services (2,5% of the total population). This is caused by the low quality of donor types of equipment and incompetent workers. In addition, the current regulation on blood availability monitoring seems rather complex and difficult process. The purpose of this study is to create an integrated device that is able to test the blood type and serves a database of bloodstock in several IRC to accelerate the distribution of blood between IRC and hospital. This research utilizes the Internet of Things (IoT) using a Wi-Fi module to create a device that could send data to computers using the internet. Through an experiment of 85 respondents, results showed that the accuracy of the device in detecting blood type is 96.5%. The time taken for the data to be received by the computer varies with the internet network used. The fastest data transfer was received using a 4G network, which requires only 1.9 seconds. Meanwhile, the 3G and 2G network took around 3.17 and 18.17 seconds respectively
Foreign Students’ Intention towards a China’s Third Party Mobile and Online Payment Platform Based on Alipay
Authors: Zhou J. Aktortifan R. P.
Published: October 2021

As the times progressed, so many features of smartphones that are developed by producers in manufactures. Hardware and software are fused to deliver comfort and increase the productivity of users’ smartphone. The example of software that can help users for a convenient transaction is Alipay and Wechat Pay, a China’s third-party mobile and online payment platform developed by Alibaba Group and Tencent respectively. This research aimed to observe ex-pats’ motives in the use of a Chinese third-party online payment platform with the sample was some foreign students in Nanjing as the Alipay users. Based on Unified Theory and Acceptance and Use of Technology (UTAUT) which consists four key constructs (effort expectancy, performance expectancy, social influence, and facilitating conditions), the results found that behavioral intentions were significantly carried out by effort expectancy, performance expectancy, and facilitating conditions, while social influence factors were found to be insignificant.
Design and Building Javanese Script Classification in The State Museum of Sonobudoyo Yogyakarta
Authors: Diqi Mohammad , Muhdalifah Mujastia
Published: October 2021

The Sonobudoyo State Museum is one of the state museums in Yogyakarta where stores historical objects like the Javanese script. This Javanese script presents in street names, especially in the city of Yogyakarta to represent local content for elementary, middle, and high schools. To read and understand Javanese script, people must learn it within a specified period, whereas with Latin letters are easier and faster to understand.  The purpose of this paper is to design and build a Javanese script classification dataset to attract both adults, children, and parents as effective learning media.  We construct the dataset by using Deep Learning with the Convolutional Neural Network (CNN). Stages of making a dataset are input data, the process of building models, and training can then recognize Javanese script images. We collect the dataset from the internet and several different people to train computer machines. In this paper, we construct the Javanese script classification dataset to help users to detect Javanese characters. The results of this training the application of Javanese script classification can produce a certain level of recognition of Javanese script patterns in a real application.
Modern Web Semantic Application For Selling Fish
Authors: Endah Marselina
Published: October 2021

Betta fish is famous as a fighter fish with a difference between betta fish with other types of fishes. Many people are interested in buying the Betta fish with a beautiful tail and attractive color with a giant belly. Thus, the paper aims to build a Semantic Web with API of delivery services. We design a system to enable and increase the betta fish sales of the Yogyakarta Community, Indonesia. We construct an application with REST of a web semantics to retrieve various data, including places and shipping cost of items to enable buyers to estimate fish prices and shipping costs.
IMPLEMENTASI ARTIFICIAL NEURAL NETWORK PADA FIELD PROGRAMMABLE GATE ARRAY (FPGA) DALAM SISTEM IDENTIFIKASI ODOR
Authors: Sari Dini Fakta , Rivai Muhammad , Mujiono Totok
Published: October 2021

ABSTRAKPenggunaan Field Programmable Gate Array (FPGA) untuk implementasi artificial neural network memberikan fleksibilitas dalam sistem pemrograman. Implementasi digital pada artificial neural network menggunakan FPGA dan menggunakan fungsi aktivasi nonlinier. VHDL digunakan untuk mengimplementasikan artificial neural network pada FPGA Xilinx XC3S500E-FG320 dengan perangkat lunak Xilinx ISE Webpack 8.2i. Kecepatan operasi FPGA Xilinx XC3S500E-FG320 dapat ditingkatkan dengan menggunakan metode lookup table (LUT). Jumlah LUT yang digunakan untuk perancangan artificial neural network dengan 3 neuron pada lapisan input, 4 neuron pada lapisan output dengan 1 neuron pada lapisan tersembunyi adalah sebesar 1407 LUT, untuk 5 neuron pada lapisan tersembunyi sebesar 4549 LUT, untuk 10 neuron pada lapisan tersembunyi sebesar 6378 LUT dan untuk 15 neuron pada lapisan tersembunyi sebesar 10084 LUT. Sistem dentifikasi odor, dilengkapi dengan sensor resonator kuarsa, pengkondisi sinyal, FPGA dan display. Model Multi Layer Perceptron (MLP) dengan metode pembelajaran Back Propagation (BP) yang digunakan untuk klasifikasi odor. Artificial neural network terdiri dari 3 neuron pada lapisan input, 10 neuron pada lapisan tersembunyi dan 4 neuron pada lapisan output yang diimplementasikan pada FPGA. Tingkat keberhasilan artificial neural network untuk identifikasi amoniak sebesar 93%, untuk pertamax sebesar 90%, untuk alkohol sebesar 92% dan untuk minyak tanah sebesar 85%.Kata kunci : Odor, sistem identifikasi odor, Artificial neural network, dan FPGA.
ANALISIS METODE SISTEM PAKAR UNTUK MENENTUKAN JENIS PENYAKIT DALAM DENGAN METODE CERTAINTY FACTOR
Authors: Hidayat Herry , Kriestanto Danny
Published: October 2021

ABSTRAKPenyakit dalam memiliki banyak variasi indikasi dan gejala yang muncul hampir sama. Hal ini menyebabkan banyak tenaga medis, atau bahkan masyarakat umum merasa sulit untuk mengenali jenis penyakit apa yang sedang diderita.Aplikasi yang dikembangkan adalah sistem pakar yang digunakan untuk mendiagnosa penyakit dalam dengan menggunakan metode Certainty Factor. Diagnosa dilakukan dengan menganalisis masukan gejala dengan bentuk pertanyaan tentang apa yang diderita oleh pasien. Aplikasi ini dapat menggunakan tiga macam metode untuk melakukan kepakaran, yakni: wawancara, pemeriksaan fisik, dan pemeriksaan penunjang. Masukan gejala akan diproses dengan menggunakan aturan-aturan tertentu yang mengacu pada pengetahuan pakar atau dokter yang telah disimpan dalam kaidah diagnosa.Hasil dari sistem pakar ini adalah satu penyakit yang mempunyai nilai kepastian terbesar. Nilai faktor kepastian tergantung pada berapa banyak kecocokan antara masukan gejala dan penyakit serta nilai faktor kepastian untuk setiap gejala penyakit. Dari angka-angka yang diperoleh dapat dipastikan bahwa analisis dengan menggunakan metode wawancara mendapat hasil kepastian paling besar jika dibandingkan dengan kedua metode lainnya.Kata kunci: certainty factor, penyakit dalam, sistem pakar.
SISTEM INFORMASI ADMINISTRASI BEASISWA MAHASISWA UNIVERSITAS RESPATI YOGYAKARTA
Authors: Wijaya R. Nurhadi
Published: October 2021

ABSTRAK Biro Administrasi Kemahasiswaan dan Carrier Center merupakan unit yang ada Universitas Respati Yogyakarta dibawah tanggung jawab Wakil Rektor III dalam mengelola kegiatan kemahasiswaan. Salah satu kegiatan rutin yang dilakukan adalah kegiatan penerimaan beasiswa baik bersumber dari yayasan, badan pemerintah maupun instansi swasta. Dalam proses administrasi beasiswa mahasiswa selama ini masih dilakukan secara komputerisasi dengan menggunakan aplikasi perkantoran dan berkas masih disimpan secara manual pada rak penyimpanan yang tentunya beresiko pada kerusakan dokumen. Masalah lain yang timbul adalah data yang diolah belum terekam dengan basisdata sehingga apabila membutuhkan riwayat penerima beasiswa pada tingkat program studi atau Fakultas membutuhkan waktu yang lama. Selain itu sering terjadi seorang mahasiswa memperoleh beasiswa ganda dikarenakan tidak adanya monitoring dari penerima beasiswa.Tujuan penelitian adalah mengembangkan Sistem Informasi Administrasi Beasiswa Mahasiswa Universitas Respati Yogyakarta. Pengembangan Sistem Administrasi Beasiswa Mahasiswa nantinya berbasis Web dengan Bahasa pemrograman PHP dan DBMS MySql sebagai basisdata. Hasil penelitian diharapkan memberikan manfaat bagi unit beasiswa untuk dapat mempermudah dalam pengelolaan dokumen administrasi penerimaan beasiswa mahasiswa di Universitas Respati Yogyakarta.  Kata kunci  : Beasiswa, Mahasiswa, Sistem Informasi
PERANCANGAN ALAT PENGHITUNG BAKTERI
Authors: Wijaya Raden Candra , Utari Evrita Lusiana , Yudianingsih Yudianingsih
Published: October 2021

INTISARIPentingnya mengetahui perkembangan suatu bakteri dalam sampel diperlukan karena tingkat perkembangan bakteri berbeda-beda. Untuk menghitung jumlah perkembangan bakteri dilakukan menggunakan alat penghitung bakteri dengan metode hitung preparat. Alat penghitung bakteri dirancang dengan sitem akumulasi nilai/jumlah bakteri yang ditampilkan pada alat penghitung yang dilengkapi dengan sistem penanda dan sistem memori yang memungkinkan untuk menampilkan hasil hitung yang sebelumnya sebanyak 10 kali secara berurutan, bakteri yang ditampilkan merupakan perkiraan dari jumlah bakteri pada satu kotak dalam preparat menggunakan perbandingan preparat berukuran 4mm2 dan preparat berukuran 9mm2 dengan uji coba sampel yakni 0,2ml, 0,4ml, 0,6ml, 0,8ml, dan 1,0ml, dari kedua perbandingan penghitungan tersebut preparat berukuran 4mm2 yang penghitungannya lebih akurat dalam penghitungan menggunakan 5 sampel dengan kapasitas yang berbeda.Kata Kunci : Bakteri, Preparat, Sampel.
PENERAPAN FRAMEWORK DENGAN ARSITEKTUR MODEL-VIEW-CONTROLLER PADA PENGELOLAAN DATA PENELITIAN DAN PENGABDIAN KEPADA MASYARAKAT
Authors: Sumiyatun Sumiyatun , Astuti Femi Dwi , Windarti Syamsu
Published: October 2021

ABSTRAKTeknologi web yang saat ini sedang berkembang dan mulai banyak digunakan adalah dengan menggunakan framework.Framework merupakan kumpulan script (terutama class dan function) yang dapat membantu developer/programmer dalam menangani berbagai masalah-masalah dalam pemrograman.Penelitian ini mengimplementasikan framework dengan arsitektur model view controller untuk mengelola data penelitian dan pengabdian pada masyarakat di STMIK AKAKOM. Framework yang digunakan dalam penelitian ini adalah Code Igniter. Code Igniter merupakan salah satu framework yang dibangun menggunakan konsep MVC (Model-View-Controller) development pattern.Aplikasi pengelolaan data penelitian dan pengabdian pada masyarakat menjadi lebih mudah dikelola, lebih terstruktur dan memiliki standar pemrograman yang jelas setelah dibangun dengan menggunakan konsep MVC.Kata kunci :Code Igniter, Framework, MVC, Penelitian, Pengabdian
ANALISIS INFORMASI FISIS RADIOGRAF PANORAMIK DIGITAL UNTUK DETEKSI TUMOR JINAK PADA RAHANG
Authors: Lestari Sri
Published: October 2021

INTISARIAplikasi instrumen medis yang menggunakan sinar-X telah mengalami perkembangan yang pesat untuk penegakan diagnosiskhususnyadalamkedokterangigi. Evaluasi radiologis yang tepat terhadap suatu lesi dapat memberikan dampak yang signifikan dalam proses diagnosis dan perawatan yang tepat bagi pasien.Secara radiografis, kondisi patologis tercitrakan sebagai sebuah lesi yang ditemukan pada tulang rahang.Penelitianinibertujuanuntukmemperoleh metode pengenalan pola yang efektif untuk menampilkan karakteristik kondisi patologis rahang, khususnya untuk menyajikan informasi bentuk dan gambaran tepi lesinya.Analisis terhadap citra radiograf panoramik telah dilakukan untuk mendeteksi adanya lesi jinak pada rahang bawah (mandibula)menggunakan surface plot dan plot profile. Pemilihan data radiograf dilakukan dengan bantuan dokter gigi. Sampel penelitianadalahradiograf panoramik digital yang telah melalui proses quality assurance (QA) oleh dokter gigi.Berdasarkanhasil yang diperoleh, analisis surface plot dan profile plot terhadap Region of Interest (ROI) radiograf panoramik digital dapat digunakan sebagai metode pengenalan pola lesi jinak pada rahang.Kata kunci: panoramik, tumor jinak, rahang, surface plot, plot profil
REVIEW: METODE PENGAMANAN DATA PADA PUBLIC INSTANT MESSENGER
Authors: Wanda Putra
Published: October 2021

Abstrak –Saat ini, perkembangan Instant Messenger sangat pesat, salah satu aspek yang menjadi perhatian adalah tentang keamanan pesan yang dikirim melalui Mobile Instant Messenger yang harus melewati jalur komunikasi internet. Ada banyak metode yang telah dikembangkan untuk meningkatkan aspek pengamanan data meliputi penggunaan algoritma kriptografi keamanan seperti RSA-Triple DES, penggunaan algoritma AES pada protokol Off The Record (OTR), penggunaan algoritma Kurva Hyper Elliptic serta penggunaan jaringan virtual pada skema pengamanan.Pada umumnya arsitektur komunikasi Instant Messenger dapat dibagi menjadi dua arsitektur yaitu arsitektur client server dan peer to peer (P2P). Makalah ini mendeskripsikan berbagai metode pengamanan yang telah dikembangkan untuk meningkatkan keamanan komunikasi pada Public Instant Messenger.Kata Kunci : Algortima, Keamanan, Mobile Banking
PEMBUATAN APLIKASI NOTES MENGGUNAKAN ALGORITMA KRIPTOGRAFI POLYALPHABETIC SUBSTITUTION CIPHER KOMBINASI KODE ASCII DAN OPERASI XOR BERBASIS ANDROID
Authors: Muhammad Aziz Fatchu Rachman Rizqi Sukma Kharisma,
Published: October 2021

Di era digital ini, teknologi berbasis android berkembang begitu cepat. Maka dari itu faktor keamanan sangat berperan penting, sehingga seluruh aplikasi berbasis mobile butuh keamanan. Saat ini menyimpan catatan singkat baik bersifat umum dan pribadi tidak membutuhkan buku dan pena lagi. Kita dapat menyimpannya di smartphone karena hampir semua masyarakat memilikinya. Kerahasiaan informasi catatan tersebut tentunya tidak ingin diketahui dan dicuri oleh orang lain. Maka dari itu dibutuhkannya suatu sistem keamanan yang dapat menjaga informasi tersebut yaitu aplikasi note menggunakan kriptografi. Dengan menggunakan kriptografi ini, informasi yang kita simpan dapat dienkripsi dan dideskripsi dengan suatu kunci yang kita inputkan sehingga hanya kita saja yang tahu isi dari informasi tersebut.Keywords – Polyalphabetic Substitution Cipher, Notes, ASCII, XOR.