bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of C-reactive protein and gastric aspirate polymorphs in early onset neonatal sepsis
Authors: Kaur Sukhdeep , Singh Kunwar Pal
Published: May 2021

Background: Neonatal septicemia is a major cause of morbidity and mortality in the neonates. It presented a diagnostic challenge in the resource poor setting of most of the developing countries of world.Methods: This prospective observational study included all term and preterm babies inborn and outborn referred cases. We included neonates less than 7 days of age with clinical suspicion of sepsis. Significant values for screening tests were taken as total leucocyte count (TLC) of >25,000/<5000, C-reactive protein>0.6 mg/dl and gastric aspirate polymorphs>5 per HPF. Sepsis screen was considered positive for two or more positive tests. Blood culture was used as the gold standard. The statistical analysis was done using SPSS 22.0 version.Results: A total number of 60 subjects were included in the study with 45 (75%) as outborn neonates. Most of them presented with tachypnea followed by difficulty in feeding and lethargy. Significant p values were observed using CRP and gastric aspirate polymorphs as independent sepsis screening markers and when combined together (p<0.001).Conclusions: Sepsis screen in neonates is required for detection of infection as blood culture may be negative and even positive result takes time. CRP showed high sensitivity. Gastric aspirate cytology with its relatively high specificity and negative predictive values serves as a good screening tool to rule out neonates unaffected by sepsis. When all the three parameters were combined together, sensitivity and specificity increased to 100% and 91.67% respectively with p values of 0.001.
Awareness of newborn hearing screening in pediatricians and gynaecologists in Maharashtra, India
Authors: Pathak Ramji D. , Deshpande Shweta S.
Published: May 2021

Background: A successful implementation of newborn hearing screening program requires the active participation of several health care professionals like pediatricians, gynaecologists, neonatologists, nurses and audiologists. These professionals help the parents through the process of screening, diagnosis and intervention. If they are made alert and informed regarding the importance of hearing screening, then accurate diagnosis and early intervention of hearing loss will be possible. Hence, the aim was to study the awareness of newborn hearing screening among pediatricians and gynaecologists in the state of Maharashtra, India.

Methods: Questionnaire was prepared based on the review of literature and after content validation it was administered on 50 paediatricians and 50 gynaecologists via electronic mail and hard copy. Each participant had to place a tick against correct alternative out of 2 alternatives for each question.

Results: The present study revealed that overall awareness level of newborn hearing screening was moderate to high in pediatricians and moderate in gynaecologists. Independent sample t test indicated that there was a significant difference present in the awareness level of pediatricians and gynaecologists.

Conclusions: Majority of paediatricians and gynaecologists lacked complete information regarding the protocol, test procedures used in hearing screening and role of audiologists. Thus, continued education programs are necessary for updating the knowledge base regarding newborn hearing screening in primary care physicians.
VİTAMİN D VE COVİD-19 ENFEKSİYONU
Authors: Tuncer Zeliha
Published: May 2021

Yeni koronavirüs COVID-19 pandemik hastalığının klinik ve ekonomik yükünü azaltmak için önlemler alınmaya ve tedaviler geliştirilmeye devam etmektedir. Hastalığın tanısında tercih edilen test yöntemi ağır akut solunum yolu yetersizliği sendromunda (SARS) olduğu gibi eş zamanlı polimeraz zincir reaksiyonu (PCR)’dır. Yeni nesil sekanslama, metagenomiks gibi ileri düzey sekanslamalar ile elde edilen sekans verisi, virüsün kaynağını ve nasıl yayıldığını anlayabilmek için oldukça önemlidir. İleri düzey sekanslamalar mutasyon takibi için önemlidir ve devam etmektedir. Global olarak devam eden COVID-19 enfeksiyonu salgınını, yayılımını sınırlamak ve tedavi etmek için insan koronavirüs enfeksiyonlarının laboratuvar tanısı oldukça önemlidir ve serolojik testler moleküler testlerle beraber değerlendirilmelidir. COVID-19 hastalarında SARS-CoV-2 virüsü konakçı hücrelere girmek için enfekte hastaların solunum yollarında anjiyotensin dönüştürücü enzim 2 reseptörüne bağlanır. Hastalığın erken evrelerinde koruyucu bağışıklık yanıtı virüsü ortadan kaldırmaktan sorumludur ve dolayısıyla bağışıklık yanıtlarını iyileştirecek stratejiler bu aşamada oldukça önemlidir. Hastalık ilerledikçe, pro-enflamatuar sitokinlerin, yani interlökinlerin salınmasına bağlı olarak akciğer iltihabı ve fibrozisi ortaya çıkar. SARS-CoV-2'ye karşı bağışıklık tepkisi ile ilgili bilgi boşluğu hastalığın tedavisi için bariyer oluşturmaya devam etmektedir. D vitamini immünomodülatör, antienflamatuar, antifibrotik ve antioksidan rollere sahip geniş spektrumlu bir sekosteroiddir. D vitamininin immünomodülatör ve antienflamatuar rollere sahip olması D vitaminin SARS-CoV-2 enfeksiyonuna karşı fayda sağlayabileceği varsayılmaktadır. D vitamininin soğuk algınlığı riskini azalttığının kanıtlanması, hücresel bağışıklığı arttırmasının anlaşılması, adaptif bağışıklığı modüle etmesi, ve antioksidasyon ile ilgili genlerin ifadesini arttırmasından dolayı COVID-19’u önlemek ve tedavi etmek için D vitamini takviyesi önerilmiştir. D vitamini düzeyleri ile COVID-19 şiddeti ve mortalitesi arasındaki ilişki konusunda yeterli kanıt henüz yoktur ve bu hipotezi test etmek için randomize kontrollü çalışmalar ve büyük ölçekli kohort çalışmaları gereklidir
Wavelet-Gaussian Process Regression Model for Regression Daily Solar Radiation in Ghardaia, Algeria
Authors: Ferkous Khaled , Chellali Farouk , Kouzou Abdalah , Bekkar Belgacem
Published: May 2021

Several methods have been used to predict daily solar radiation in recent years, such as artificial intelligence and hybrid models. In this paper, a Wavelet coupled Gaussian Process Regression (W-GPR) model was proposed to predict the daily solar radiation received on a horizontal surface in Ghardaia (Algeria). A statistical period of four years (2013 -2016) was used where the first three years (2013-2015) are used to train model and the last year (2016) to test the model for predicting daily total solar radiation. Different types of wave mother and different combinations of input data were evaluated based on the minimum air temperature, relative humidity and extraterrestrial solar radiation on a horizontal surface. The results demonstrated the effectiveness of the new hybrid model W-GPR compared to the classical GPR model in terms of Root Mean Square Error (RMSE), relative Root Mean Square Error (rRMSE), Mean Absolute Error (MAE) and determination coefficient (R2).
Editorial
Authors: Guimarães Mayara Ribeiro
Published: May 2021

Editorial
Sensory Evaluation of Dry Persimmons of the Tipo (Diospyros kaki L. f.) Variety
Authors: Vogrin Andrej , Marko Petra , Unuk Tatjana
Published: May 2021

The study carried out at the Faculty of Agriculture and Life Sciences of the University of Maribor aimed to evaluate the attractiveness of dried persimmon fruit depending on the method of preparing the fruit for drying. The methods varied in terms of the ripeness of the fruit, the thickness and shape of the slices, the presence of seeds (in fertilised fruits) and the presence of peel. Sensory evaluation was performed by students and staff, using a hedonic scale, where evaluators evaluated the appearance (shape and colour) and taste (sugar-acid ratio, texture, tartness, presence of fruit peel, and general impression) of the fruit. Dried unfertilized persimmons, with the presence of peel, cut into 3 mm thick slices, were given the highest score for overall attractiveness. In terms of taste, unfertilised, peeled persimmon slices scored the highest. Considering all parameters, the results showed that unfertilised persimmons were more suitable for drying and that the presence of the peel was not a disturbing factor for consumers.
СОЦИОЛОГИЧЕСКИЙ АНАЛИЗ СОЦИАЛЬНОЙ БЕЗОПАСНОСТИ СОВРЕМЕННОГО КРУПНОГО РОССИЙСКОГО ПРЕДПРИЯТИЯ
Authors: Кареева Анна Петровна
Published: May 2021

Актуальность исследования определена наличием в современном обществе значительного количества рисков и желанием людей, живущих в нем, обезопасить себя от их негативного воздействия. Социальная жизнь в таком рискогенном обществе характеризуется неопределенностью. Институциональные среды риска охватывают как отдельные социальные группы, так и все человечество. Безопасность при этом выступает сдерживающим элементом, который не дает разрушить сложившуюся социальную структуру данного общества и смягчает возникающие в нем социальные риски.  Цель работы: изучить социальную безопасность современного крупного российского предприятия, создать теоретическую модель и провести её практический анализ. Методы исследования: теоретико-методологической основной исследования стали труды ученых, сформировавших основные подходы к пониманию концепции «общества риска», теории институциональных матриц, социальной безопасности, социологии труда и универсумной социологической парадигмы. В рамках исследования проведен социально-исторический анализ открытых документальных источников, контент-анализ печатных средств массовой информации, анкетный опрос и сравнительный анализ представлений руководства и работников отдельных промышленных предприятий атомной отрасли. Результаты: выявлены основные характеристики социального риска, дано его определение, описана социальная сфера современного рискогенного общества. Безопасность при этом рассмотрена как базовый социальный институт такого общества. В нем выделены «внутренняя структура» института и его институциональные формы. Социальная безопасность определена одной из таких форм. Анализ социальной безопасности крупного российского предприятия проведен на различных уровнях социума (макро-, мезо- и микроуровень), создана теоретическая модель. Практический анализ теоретической модели социальной безопасности проведен на отдельных промышленных предприятиях атомной отрасли. Такими предприятиями стали ГХК (г. Железногорск, Красноярский край), СХК (г. Северск, Томская область), ПО «Маяк» (г. Озерск, Челябинская область) и Атомфлот (г. Мурманск, Мурманская область).
Redes de coautoria dos programas brasileiros de pós-graduação em Contabilidade
Authors: Welter Larissa Marx , Souza Ângela Rozane Leal de , Trajano Brenda Borba , Behr Ariel
Published: May 2021

Este estudo objetivou analisar a configuração da rede social de coautoria dos programas de pós-graduação stricto sensu em Contabilidade existentes no Brasil, no quadriênio 2013-2016, a partir da produção docente de artigos publicados em periódicos científicos. Realizou-se um estudo documental, analisando-se, a partir de ferramentas de caráter sociométrico, 291 currículos lattes de todos os docentes permanentes de 21 programas de pós-graduação em Contabilidade, com mestrado e doutorado. Os principais achados da pesquisa indicam baixa densidade das redes sociais de coautorias dos docentes. Porém, observa-se uma elevação dessa densidade, se comparada com estudos similares anteriores, indicando um aumento histórico das coautorias. Verificou-se que características individuais dos docentes influenciam seus potenciais de contribuição para fomento das parcerias, tanto entre autores quanto entre programas de pós-graduação.
A távközlés történeti fejlődése és hatása a magyar GDP-re
Authors: Máténé Bella Klaudia , Ritzlné Kazimir Ildikó
Published: May 2021

A szerzők idősorelemzés módszerével elemzik a magyarországi távközlésben bekövetkezett technológiai változások és a gazdasági növekedés kapcsolatát 1995 és 2019 között. A rendelkezésre álló adatok alapján a legtöbb új telekommunikációs technológia elterjedése logisztikus függvénnyel írható le a vizsgált időszakban. Az iparág innovációi folyamatosan egymást váltó logisztikus görbék sokaságaként jellemezhetők, amelyek nemcsak a távközlés nemzetgazdasági ágazat bruttó hozzáadott értékéhez járulnak hozzá, hanem a teljes nemzetgazdaság növekedéséhez is. Az ökonometriai elemzés alapján egy logisztikus görbe lefutását mutató, adott technológiát leíró változó az inflexiós pont utáni időszakban szignifikánsan hozzájárul a bruttó hazai termék (gross domestic product, GDP) növekedéséhez. Ennek magyarázata az lehet, hogy az új technológia bevezetésekor elinduló exponenciális növekedés a tőkebefektetések, az infrastruktúraépítés és a piaci elterjedés időszakára tehető, ezt követően azonban a jelentős elterjedtség és a hálózati externáliák léte együttesen indokolja a GDP és az indikátor közötti kapcsolatot. Ez a megállapítás egybecseng azzal a neo-schumpeteri elmélettel, mely szerint egy adott technológia az inflexiós pont után kerül a szinergia és az érettség szakaszába.
ministerio de la escritura
Authors: Espinosa Mariana
Published: May 2021

Este artículo indaga la fe en el poder evangelizador de la escritura (considerada como un ministerio) en las interacciones entre misioneros hermanos libres y comunidades indígenas del Noroeste de la Argentina. La observación etnográfica de múltiples usos de esta “tecnología del intelecto” indujo a una pormenorizada reconstrucción histórica de las formas de producción, circulación y apropiaciones de impresos y de las prácticas asociadas a la expansión de la propuesta evangélica entre Buenos Airees y el NOA. A través de material etnográfico, documental y bibliográfico se busca problematizar y comprender la presencia e integración selectiva de los impresos en términos de objetos y relaciones de mediación cultural.
Are video games the best way to stay-at-home?
Authors: Kristanto Damar , Aly M. Nilzam , Suharto Bambang , Yuliawan Rahmat , Firdaus Aji Akbar
Published: May 2021

The COVID-19 pandemic has disrupted many aspects of normal social life. The community is required not to leave the house too much if it is not necessary. Often during times of independent isolation or in personal cases, people are afraid to leave the house. They are faced with boredom so this is an opportunity for the digital entertainment industry to develop. On the other hand, many violations of COVID-19 health protocols still occur in society and people are still reluctant to stay-at-home. The question is what medium is good for persuasion as well as giving pleasure to people to entertain themselves during independent isolation and with low levels of boredom. Video games are a growing industry during the COVID-19 pandemic, unfortunately, this media has not been widely used as a means of persuading people to obey health protocols and stay-at-home. This study shows a correlation between gaming activity and the tendency not to leave the house. Besides, what types of games have the potential to keep someone from leaving the house are also discussed in this paper.
Personality Traits and Ethical Belief as Factors Influencing Fraud Intent Behaviour among Bank Employees in Ibadan, Nigeria.
Authors: Ishola Ajibola Abdulrahamon , Kenku Akeem Adekunle , Adedayo Olufunmilayo
Published: May 2021

Fraud is an ever-growing problem for financial institutions in Nigeria, with criminals using a wide variety of methods. Unfortunately, employees were fingered in most of these fraudulent activities. Previous studies focused on contextual and organizational antecedents of motivating engagement in fraudulent practices and less on employees’ dispositional factors. This study examined the role of personality traits and ethical beliefs on fraudulent behaviour among bank employees. The study was a cross-sectional study. Three hundred and fifty-three (353) employees in the middle to junior level management cadre were selected through stratified sampling technique from banking organisations operating in the Ibadan metropolis. The respondents responded to a self-report questionnaire measuring fraudulent behaviour intention and red flags; personality traits and Ethical position questionnaire. Two hypotheses were tested using multiple regression, Pearson correlation analysis and ANOVA at p≤0.05. Results demonstrated that conscientiousness personality trait was the only predictor of fraud intent behaviour among the personality variables. Employees with Absolutist ethical principles reported lower fraud intent behaviour than those with subjectivist ethical philosophy. The study concludes that personality traits and ethical beliefs were powerful motivators for fraud behavior. Thus, fraud and HR experts were enjoined to utilize psychological profiles in fraud investigations and selection of employees.
Gas Emissions from Mixed Coal-Biomass Derived Fuel Burned in an Industrial Boilers
Authors: Nurhayati Annita
Published: May 2021

Textille industry consumes huge amount of coal to operate their boiler. At the same time, the company generated huge amount of bottom ash from the boiler operation and it is considered as hazardous waste. PT. X has been attempting to reuse bottom ash mixed with solid waste compost to generate biofuel named as biomass coal fuel (BCF) briquettes as co-fuel for boiler combustion. This study conducted two boiler combustion experiments: i) co-firing boiler operation with 90% coal and 10% of BCF, and ii) 100% of coal. The SO2 and NO2 emissions were measured from the two experiments. The emission test was carried out using the MRU Optima 7 which is  equipped by an electrochemical sensor, combined with an extraction probe to be inserted into the stack. From the emission test results, the SO­2 concentration of 100% of coal burning was 150 mg/Nm3. SO2 concentration of coal fuel with a substitution of 10% BCF was 498.8 mg/Nm3. The NO2 concentration from 100% coal combustion was 174.2 mg/Nm3 while from mixed fuel combustion was 370.3 mg/Nm3. Using BCF as an aggregate for coal combustion did not bring in lower emissions of SO2 and NO2. Emission factor for SO2 from 100% coal combustion is 6.295 g/kg while for coal fuel with a substitution of 10% BCF is 31.09 g/kg. NO2 emission factor from 100%, coal burning is 7.31 g/kg while the emission factor of NO2 in coal fuel with a substitution of 10% BCF is 23.31 g/kg.
Is Antibiotics Overuse Justified When Immediate Intervention Is Not Possible? A Rapid Evidence Review
Authors: Ibrahim Nour , Noujeim Ziad , Aoun Georges , El-Outa Abbass
Published: May 2021

This review revisits clinical use of antibiotics for most common acute oro-dental conditions; we aim to provide evidence governing antibiotics use when access to oral healthcare is not available, as during the ongoing outbreak of the severe acute respiratory syndrome coronavirus 2. In this rapid review, articles were retrieved after conducting a search on PubMed and Google Scholar. Relevant publications were selected and analyzed. Most recent systematic reviews with/without meta-analyses and societal guidelines were selected. Data were extracted, grouped, and synthesized according to the respective subtopic analysis. There were evidence supporting the use of antibiotics in common oro-dental conditions as temporary measure when immediate care is not accessible, such as in case of localized oral swellings as well as to prevent post-extraction complications. No sufficient evidence could be found in support of antibiotic use for pain resulting from pulpal origin. Consequently, antibiotic use may be justified to defer treatment temporarily or reduce risk of complications in case of localized infection and tooth extraction, when no access to immediate dental care is possible.
RNA Extraction Alternative Method for SARS-CoV-2 Molecular Diagnosis
Authors: Bianchini Elisa , Rossignolo Francesco , Perfranceschi Melissa , Cazzin Chiara , Silva Ronaldo , Formenti Fabio , Perandin Francesca , Griffante Cristiana , Remelli Rosaria , Padovani Michela , Scarso Salvatore , Leonardi Martina , Piubelli Chiara
Published: May 2021

Background: the devastating outbreak of COVID-19 poses serious challenges for the diagnostics laboratories, which are often facing global shortage of reagents and equipment. With the aim of increasing the diagnostic throughput for SARS-CoV-2 molecular test, the purpose of this study was to validate an additional RNA extraction method respect to those already recommended by WHO and the US Centers for Disease Control and Prevention (CDC). Methods: a new protocol for RNA extraction from nasopharyngeal swab was set up, adapting the Qiagen RNeasy 96 plate and validated on a set of 100 clinical samples analyzed in parallel by Roche-Magnapure method (already recommended by CDC guidelines). Results: the internal control and target genes analysis showed a good agreement between the two extraction methods indicating that the two methods can be considered equivalent and that the RNeasy-adapted method can be applied for the SARS-CoV-2 diagnostics. The addition of this new extraction method resulted in a throughput increase for SARS-CoV-2 molecular test of about 2000 samples/month during the initial months of the pandemic emergency in which the lack of reagents for the extraction led to an insufficient sample processing throughput of the analysis of the swabs.
Multi-Walled Carbon Nanotubes (MWCNTs) Cause Cellular Senescence in TGF-β Stimulated Lung Epithelial Cells
Authors: Lucas Joseph , Wang Qixin , Muthumalage Thivanka , Rahman Irfan
Published: May 2021

Multi-walled carbon nanotubes are engineered nanomaterials (ENMs) that have a fiber-like structure which may be a concern for the development of cellular senescence. Premature senes-cence, a state of irreversible cell cycle arrest, is implicated in the pathogenesis of chronic lung dis-eases such as pulmonary fibrosis (PF). However, the crosstalk between downstream pathways mediating fibrotic and senescent responses of MWCNTs is not well defined. Here, we exposed human bronchial epithelial cells (BEAS2B) to MWCNTs for up to 72 hours and demonstrate that MWCNTs increase reactive oxygen species production (ROS) accompanied by inhibition of cell growth and proliferation. In addition, exposure resulted in the increase of p21 protein and senes-cence associated β-galactosidase (SA β-gal) activity. We also determined that co-exposure with the cytokine, transforming growth factor-β (TGF-β) exacerbated cellular senescence indicated by increased protein levels of p21, p16, and γH2A.X Furthermore, the production of fibronectin and plasminogen activator inhibitor (PAI-1) was significantly elevated with the co-exposure compared to MWCNTs or TGF-β alone. Together, this suggests that the senescence potential of MWCNTs may be enhanced by pro-fibrotic mediators in the surrounding microenvironment.
Freeze versus Spray Drying for Dry Wild Thyme (Thymus serpyllum L.) Extract Formulations: The Impact of Gelatin as a Coating Material
Authors: Jovanović Aleksandra A. , Lević Steva M. , Pavlovic Vladimir B. , Markovic Smilja B. , Pjanovic Rada V. , Đorđević Verica B. , Nedović Viktor , Bugarski Branko M.
Published: May 2021

Freeze drying was compared with spray drying regarding feasibility to process wild thyme drug in order to obtain dry formulations at laboratory scale starting from liquid extracts produced by different extraction methods: maceration, heat-, ultrasound-, and microwave-assisted extractions. Higher powder yield (based on the dry weight prior to extraction) was achieved by freeze than spray drying and lower loss of total polyphenol content (TPC) and total flavonoid content (TFC) due to the drying process. Gelatin as a coating agent (5% w/w) provided better TPC recovery by 70% in case of lyophilization and higher powder yield in case of spray drying by diminishing material deposition on the wall of the drying chamber. The resulting gelatin-free and gelatin-containing powders carried polyphenols in amount ~190 and 53-75 mg gallic acid equivalents GAE/g of powder, respectively. Microwave-assisted extract formulation distinguished from others by higher content of polyphenols, proteins and sugars, higher bulk density and lower solubility. The type of the drying process affected mainly position of the gelatin-derived -OH and amide bands in FTIR spectra. Spray dried formulations compared to freeze dried expressed higher thermal stability as confirmed by differential scanning calorimetry analysis and higher diffusion coefficient; the last feature can be associated with the lower specific surface area of irregularly shaped freeze-dried particles (151-223 µm) compared to small microspheres (~8 µm) in spray-dried powder.
Corporate Social Responsibility Strategies in Spanish Electric Cooperatives. Analysis of Stakeholder Engagement
Authors: Campillo-Alhama Concepción , Igual-Antón Diego
Published: May 2021

Cooperative organizations try to balance economic viability and Corporate Social Responsibility (CSR) management through strategic policies that involve dialogue, participation and engagement with stakeholders. To measure the impact of CSR management, the electricity sector implements monitoring processes and models, such as the Sustainability Reporting Standards of the Global Reporting Initiative (GRI), which measure contributions to the Sustainable Development Goals (SDGs) of the United Nations 2030 Agenda. This research analyses the strategic management of CSR in the 28 electric cooperatives that market electricity in Spain with the aim of determining their level of commitment to CSR and stakeholder participation in their corporate policies. The analysis is based on the descriptive-exploratory study of the whole population of electric cooperatives. The results indicate that the CSR management of most electric cooperatives is still in an emerging stage within the Value Curve. Importantly, there is a significant percentage of cooperatives that have already advanced towards the consolidating and institutionalized stages. However, most of these social-economy organizations are not developing programs that link their CSR strategies with their priority SDGs and sustainability as commitment to their community.
SIKAP DAN MOTIVASI PETANI DALAM BUDIDAYA TANAMAN SEMANGKA DI LAHAN PASIR PANTAI, KABUPATEN PURWOREJO, JAWA TENGAH
Authors: Kusumaningrum Arta , Rahmawati Fitri
Published: May 2021

Attitude and motivation are two important components in cultivating watermelon plants in coastal sandy land, Purworejo Regency. There were 2 objectives of this study, namely 1) to determine the attitudes of farmers in the cultivation of watermelons in coastal sandy land, Purworejo Regency and 2) to determine the

motivation of farmers in watermelon cultivation in coastal sandy land, Purworejo Regency. Respondents involved in this study were 60 farmers in Grabag District,

Ngombol District, and Purwodadi District. The research was conducted by purposive sampling, which was carried out in accordance with the research objectives. The analysis used was Likert scale and class intervals. They were used to determine the level of attitude and motivation of farmers in watermelon cultivation in coastal sandy land, Purworejo Regency. The Likert scale used was the SS scale (Strongly Agree), S (Agree), R (Doubtful), TS (Disagree), STS (Strongly Disagree) while class intervals were divided into 3 categories, namely high, medium, and low categories. The results of this study were 1) the attitude of farmers in watermelon cultivation in the coastal sandy land of Purworejo Regency, Central Java was medium. This study showed that many farmers had a tendency to utilize coastal sandy land for watermelons cultivation in Purworejo Regency and 2) the motivation of farmers in cultivating watermelons in coastal sandy land in Purworejo Regency, Central Java was medium as well. Therefore, it revealed that many farmers had been motivated to utilize coastal sandy land to cultivate watermelon plants in Purworejo Regency.
PENINGKATAN DAYA SAING UKM OLAHAN UBIKAYU: PENDEKATAN RANTAI NILAI
Authors: Fitriani Fitriani , Unteawati Bina , Sutarni Sutarni , Fatih Cholid , Mutaqin Zainal
Published: May 2021

The strategic food resource in Lampung Province is cassava. This study

aims to identify the value chain of cassava processed products in Lampung Province. The research method used is a survey, involved 60 SMEs of cassava as respondents. Data analysis uses a value chain analysis approach. The discussion concluded that the main activities on SME value chains consist of input logistics, including procurement of raw materials in the form of fresh cassava from producer farmers, raw/semi-finished materials, and auxiliary materials. The cassava production center in East Lampung is the leading supplier of fresh cassava for the SME. Operation activities including the use of technology and skilled human resources are the key to SME efficiency. SME uses simple technology; the final handling product needs to adopt a market trend. Output logistics: distribution of products to intermediaries and retail traders through direct delivery. The production of SME needs to improve based on market demand. Marketing and sales activities involve some SME medium-scale

already have good market and distribution networks, but not the small scale.

Marketing and distribution of products still rely on traditional market networks.

Services activities carried out by industry include accuracy in meeting agreements with partners, including procurement or delivery, and the payment. Finally, the supporting activities of SME value chains will depend on the ability to identify supplier partners in the procurement of input, and facility needs furthermore will become a node of business cost and profit efficiency.
Analysis of the Impacts of Work, Non-Work and Stress Issues on the Work Family Conflict in Ivorian Industrial Sector
Authors: Choki Aristide Gbame , Zhao Qiuhong
Published: May 2021

This paper analyzes the perceptions that workers in the Ivorian industrial sector have as the interface between their professional and personal life, and the factors that facilitate or make it difficult. Data collected from 4 Ivorian industrial companies which represent a sample of 187 respondents according to the selection criteria. These collected data make it possible to identify the factors which act on the labor conflict towards the family as well as the factors which act on the family conflict towards the work within the industrial sector in Cte d’Ivoire. The results of the correlation coefficients show that the relationships between the proposed variables are significant and in the direction suggested for the most part, thus providing support for nine of the ten hypotheses affecting these relationships. According to some results obtained, it was discovered that certain factors could be at the same time, factors of conflict and satisfaction, such as the commitment to work or the nature of the work. These variables can simultaneously increase stress, and increase the self-esteem of the worker. The results of the analysis of the proposed model recommend the possibility that the data fit the model well, explaining the impacts of work, non-work and stressors on work-family conflict. This indicates that the proposed model is adapted to the Ivorian context.
Carencias y variabilidad en la calidad de la atención a neonatos hospitalizados en México. Estudio transversal en 28 hospitales públicos
Authors: Saturno-Hernández Pedro Jesús , Poblano-Verástegui Ofelia , Flores-Hernández Sergio , Martínez-Nicolas Ismael , Vieyra-Romero Waldo , Halley-Castillo María Elizabeth
Published: May 2021

Objetivo. Evaluar la calidad de la atención a neonatos con indicadores de proceso, en patologías seleccionadas. Ma­terial y métodos. Evaluación multicéntrica, transversal de nueve indicadores en 28 hospitales de 11 entidades de México. Se utilizó Lot Quality Assurance Sampling (LQAS) para estándares de calidad y muestra por hospital. Casos seleccio­nados al azar del Subsistema Automatizado de Egresos Hos­pitalarios. Se clasifican hospitales como “cumplimiento con estándar”/“no cumplimiento” por indicador y, cumplimiento con IC95% exacto binomial, regional y nacional, según mues­treo estratificado no proporcional. Resultados. Ningún indicador cumple el estándar de 75% en hospitales, con 0 a 19 hospitales que cumplen, según indicador. Excepto la iden­tificación oportuna de asfixia perinatal e inicio de antibiótico correcto en sospecha de sepsis temprana, el cumplimiento es <50% en todos los demás indicadores. Conclusiones. La calidad de la atención a neonatos en hospitales es heterogé­nea y deficiente. Se proponen indicadores para monitorizar iniciativas de mejora.
Prevalence of iron deficiency was stable and anemia increased during 12 years (2006-2018) in Mexican women 20-49 years of age
Authors: Mejía-Rodríguez Fabiola , Villalpando Salvador , Shamah-Levy Teresa , García-Guerra Armando , Méndez-Gómez Humarán Ignacio , De la Cruz-Góngora Vanessa Vianey
Published: May 2021

Objective. To compare the prevalence of women 20-49 years of age with iron deficiency anemia (IDA), iron deficiency with no anemia (IDNA), and non-ID anemia (NIDA) in com­parison during 2006, 2012 and 2018, and their association with sociodemographic characteristics and nutritional status. Materials and methods. Ensanut 2006, 2012 and 2018- 19 are comparable for measurements of anemia (hemoglobin) and Iron deficiency (ID, by ferritin). Both measurements combined were compared with year of surveys and other dependent variables using a multinomial regression. Results. In 2006, the total prevalence of anemia was 14.9% and ID 29.0%, the prevalence of IDA was 8.35%, of IDNA 20.5%, and NIDA 6.6%; in 2012, the total prevalence of anemia was 13.3%, ID was 9.6%, IDA 8.6%, IDNA 21.0% y NIDA 4.7%; in 2018 total prevalence of anemia was 21.4%, of ID 25.7%, IDA 10.5%, IDNA 15.2% and NIDA 10.9%. Conclusions. The total prevalence of anemia increased 6.5 pp between 2006 and 2018, IDNA reduced, IDA had no significant changes, the mayor increase (4.3 pp) occurred in NIDA.
A Case of Personalized Management of Carcinoma of Fallopian Tube Harboring BRCA Mutation and Sister Mary Joseph's Nodule
Authors: Chen Xi , Fu Yaoyao , Zhang Na , Li Yang , Zhang Min , wang guili
Published: May 2021

Fallopian tube malignancies have been presumed to rare incidence with dismal prognosis. However, recent data suggest that the true incidence of PFTC has been substantially underestimated. Early diagnosis of fallopian tube cancer seems difficult. The routes of metastasis of fallopian tube carcinoma are similar to those of ovarian cancer. Genetic factors are relatively important risk factors for tubal cancer. Poly ADP -ribose polymerase inhibitor is used for BRCA-mutant PFTC. In this artical, we use a rare case of navel metastatic tumor which finally be confirmed that it is originated from fallopian tube to discovered the hereditary factors through genetic testing, and reported this case to provide preventive intervention for the next generation of eugenics and incidence.
Evaluation of Four-Hand Reduction for Obturator Hernia with the Guidance of Sonography (FROGS) as a new treatment strategy for obturator hernia: A retrospective study
Authors: Togawa Yuki , Kamihata Kyohei , Nagahisa Yoshio , Kawamoto Kazuyuki
Published: May 2021

Purpose: Obturator hernias are uncommon but are important causes of intestinal obstruction. Delayed treatment can be fatal. Emergency surgery is considered the most effective treatment; however, patients with obturator hernia usually have comorbidities, and this precludes them from emergency surgery. This study aimed to evaluate the effectiveness of Four-hand Reduction for Obturator hernia with the Guidance of Sonography (FROGS) as a new treatment strategy for obturator hernia.Methods: Since November 2019, we have tried FROGS in all patients with obturator hernia at the emergency room. We retrospectively compared the clinical data of 14 patients who underwent FROGS (after-FROGS group) with those of 23 patients who did not (before-FROGS group).Results: All patients were females. There were no significant differences in age, lesion side, duration of symptoms, the diameter of the prolapsed bowel, and predisposing factors. The body mass index was significantly lower in the after-FROGS group than in the before-FROGS group. Manual reduction was successfully performed in all 14 patients in the FROGS group, whereas in the before-FROGS group, 14 patients underwent manual reduction, of whom only one was successfully treated using the non-FROGS method. Bowel resection was avoided in all 14 patients in the after-FROGS group, whereas 8 patients underwent bowel resection in the before-FROGS group. There were no significant differences in postoperative complications and mortality within 30 days after hernia presentation between the two groups.Conclusion: Manual reduction using the FROGS technique was found to be safe and reproducible and can be the first treatment choice for patients with obturator hernia.
Effect of Environmental Stressors on the mRNA Expression of Ecdysone Cascade Genes in Chironomus Riparius.
Authors: Fuente Mercedes de la , Folgar Raquel Martín , Martínez-Paz Pedro , Cortés Estrella , Martínez-Guitarte José Luis , Morales Mónica
Published: May 2021

Chemical compounds produced by humans are continuously reaching the environment. In this work, we characterised the expression patterns of important endocrine-related genes involved in the ecdysone pathway in the fourth larval instar of the model species Chironomus riparius after exposure to three chemicals: ethinyl oestradiol (EE), nonylphenol (NP) and bis(tributyltin) oxide (TBTO). We used real-time PCR to analyse the gene expression levels of: ecdysone receptor (EcR) and ultraspiracle (usp), two genes that encode the dimerising partners of the functional ecdysone receptor; the orphan receptor ERR (oestrogen-related receptor), with an unknown function in invertebrates; and E74, an early response gene induced by ecdysteroids. We estimated the bioaccumulation potential, bioavailability and physicochemical properties of these chemicals, together with a number of other exogenous agents known to interfere with the hormonal system. We also provide a review of previous transcriptional studies showing the effect of all these chemicals on ecdysone cascade genes. This analysis provides useful data for future ecotoxicological studies involving invertebrate species.
Very High Sputum Cyanide Concentrations during Acute Pulmonary Exacerbations in Cystic Fibrosis Patients
Authors: Guck Daniel , Kim David , Logue Brian , Bortey-Sam Nesta , Tubbs Nicole , Craft David , Haouzi Philippe
Published: May 2021

Background: Cyanide (CN) has been shown to be chronically present in the airways of cystic fibrosis (CF) patients, as a byproduct Pseudomonas’ metabolism. We sought to determine the concentrations of CN in the sputum of CF patients, who were admitted to the hospital with acute clinical exacerbations using 2 different approaches. Methods: Sputum was collected within 1 day (median) of admission and immediately analyzed for the presence of total and free CN. Results: We found 1) toxic levels of CN in the sputum of our patients, ranging from 27 to 401 µM, 2) the majority of the cyanide was in the form of free, thus diffusible, CN and 3) no cyanide in the blood. Conclusions: While the chronic presence of CN in patients colonized with pseudomonas is not a new concept, the present data support the view that very high levels of free cyanide are present in the airways of CF patients during an acute clinical exacerbation, i.e. levels compatible with concentrations of CN able to virtually stop the mitochondrial activity. It becomes therefore urgent to investigate whether, in CF patients, cyanide is a significant factor affecting the short and long-term outcome and whether a specific treatment of CN intoxication of the airways is warranted during an exacerbation.
Tolerance Mechanisms and Irrigation Management to Reduce Iron Stress in Irrigated Rice
Authors: Carmona Felipe de Campos , Adamski Janete Mariza , Wairich Andriele , de Carvalho Joseane Biso , Lima Gustavo Gomes , Anghinoni Ibanor , Jaeger Isadora Rodrigues , Silva Paulo Regis Ferreira da , Terra Tatiana de Freitas , Fett Janette Palma , Carlos Filipe
Published: May 2021

Iron toxicity is a major nutritional disorder in rice plants, especially in flooded areas. The use of alternative crop management practices, such as soil drainage, may mitigate negative impacts of iron toxicity, since soil aeration that follows drainage can oxidize and precipitate potentially toxic Fe+2 into Fe3+. This study aimed to evaluate the impact of alternative water management on agronomical and physiological parameters in rice plants grown in a field location with iron toxicity history. Rice cultivars BR-IRGA 409 (sensitive) and IRGA 425 (resistant to iron toxicity) were tested. Irrigation management comprised three treatments: Continuous Irrigation (CI), one cycle of water Suppression (1S) and two cycles of water Suppression (2S). Evaluations included the ionic composition of soil solution and leaf tissues, grain yield, antioxidant responses and gene expression. Permanent soil flooding resulted in higher grain yield in plants from the resistant than from the sensitive genotype, which had higher malondialdehyde (MDA) concentrations in leaves. In contrast, two cycles of alternate soil drying resulted in equivalent grain yield and MDA concentrations in both genotypes. Resistance to iron toxicity in IRGA 425 plants seems related to limited Fe translocation to shoots, increased tolerance to oxidative stress in leaves and higher expression of Ferritin, OsGAP1, OsWRKY80 and Oryzain-α genes. Plants from the BR-IRGA 409 cultivar (sensitive to Fe toxicity) improved growth and yield under the interrupted irrigation treatments, probably due to lower Fe availability in the soil solution. Management of water irrigation successfully alleviated Fe toxicity in rice plants cultivated in field conditions.
Coulomb Stress Change in Ahar-Varzaghan (20121108) Earth Quakes
Authors: Sorkhabi Omid Memarian
Published: May 2021

Understanding how the movement of faults and deformation affects such as motion-induced surface stress and strain, which is very important in seismic regions. The best way to learn about the effects of fault movement is modeled. For example, the modeling of surface displacement or deformation and the amount of damage earthquake can be estimated by the model. Coulomb stress changes can be modeled or predicted earthquake aftershocks or future Earthquakes. we employ assumptions on the orientations, rupture lengths and average slip associated with each earthquake to calculate stress changes. Using this model, we displacement, stress and strain at any depth in the Earth's surface acquired. In this study the modeling of earthquakes Mw= 6.5, Mw=6.3 Ahar-Varzaghan. The earthquakes induced displacements, strains and stresses were calculated at the surface at an average depth and its aftershocks for 10-km Ahar and 4 km Varzaghan.
Phenylpropanoid conjugated iridoids with anti-malarial activity from the leaves of Morinda morindoides
Authors: Hashim Yasinjan , Toume Kazufumi , Mizukami Shusaku , Ge Yue-Wei , Taniguchi Mayumi , Teklemichael Awet Alem , Huy Nguyen Tien , Bodi Joseph M. , Hirayama Kenji , Komatsu Katsuko
Published: May 2021

Two phenylpropanoid conjugated iridoids, deglucosyl gaertneroside (1) and morindoidin (2), were isolated from the leaves of Morinda morindoides (Rubiaceae) by activity-guided fractionation using an anti-malarial activity assay. The known related iridoids molucidin (3) and prismatomerin (4), two lignans, abscisic acid, two megastigmanes, and two flavonol glycosides were also identified. The structures of isolated compounds were elucidated using spectroscopic analysis. The isolated compounds were evaluated for anti-malarial activity against the chloroquine/mefloquine-sensitive strains of Plasmodium falciparum together with cytotoxicity against adult mouse brain cells. Potent anti-malarial activity of 3 and 4 (IC50 of 0.96 and 0.80 µM, respectively) was shown, while new iridoids 1 and 2 and pinoresinol (5) displayed moderate activity (IC50 of 40.9, 20.6, and 24.2 µM, respectively). These results indicate that 1–5 may be promising lead compounds for anti-malarial drugs and that extracts of M. morindoides leaves could be effective remedies for malaria infection.
Role of 2′-Hydroxycinnamaldehyde In The Induction of Apoptosis Via A Reactive Oxygen Species-Dependent JNK Pathway in Human Promyelocytic HL-60 Leukemia Cells
Authors: Chung Kyung-Sook , Yoo Chae-Bin , Lee Jeong-Hun , Lee Hwi-Ho , Park Sang-Eun , Han Hee-Soo , Lee Su-Yeon , Jeong Seung Yeon , Kwon Byoung-Mok , Choi Jung-Hye , Lee Kyung-Tae
Published: May 2021

Background: Because the role and molecular mechanism of 2′-hydroxycinnamaldehyde (2′-HCA) in human leukemia need to be clarified, we provide detailed insights into the mechanism underlying the anti-proliferative properties of 2′-HCA in acute myeloid leukemia (AML).Methods: We performed MTT assay to examine the cytotoxic effect of 2′-HCA. 2′-HCA-induced apoptotic pathway was demonstrated by annexin V-FITC/ propidium iodide double staining, DAPI staining for DNA fragmentation detection, and western blot analysis. ROS generation, intracellular glutathione (GSH) level, and intracellular protein thiols (PSH) were detected to investigated the mechanism of 2′-HCA-related apoptosis. Xenograft animal model was used to evaluate anti-tumor activities of 2′-HCA.Results: The present study demonstrated that 2′-HCA induced apoptosis in human promyelocytic leukemia HL-60 cells through the activation of mitochondrial pathways. 2′-HCA also induced the activation of JNK and the pharmacological inhibition of JNK effectively prevented 2′-HCA-induced apoptosis and AP-1-DNA binding. In addition, 2′-HCA resulted in the accumulation of ROS and depletion of intracellular GSH and PSH in HL-60 cells. Xenograft mice inoculated with HL-60 leukemia cells demonstrated that the intraperitoneal administration of 2′-HCA inhibited tumor growth by increasing of TUNEL staining, the expression levels of nitrotyrosine, pro-apoptotic proteins, and PCNA protein expression. Conclusion: Our findings suggest that 2′-HCA induces apoptosis via the ROS-dependent JNK pathway and could be considered as a potential therapeutic agent for leukemia.