bluuebunny/crossref_metadata_2025 huggingface dataset:
Variations of the stellar Initial Mass Function in semi-analytic models: Implications for the mass assembly of galaxies in the GAEA model
Authors: Fontanot Fabio
Published: June 2020

A wealth of observations recently challenged the notion of a universal stellar initial mass function (IMF) by showing evidences in favour of a variability of this statistical indicator as a function of galaxy properties. I present predictions from the semi-analytic model gaea (GAlaxy Evolution and Assembly), which features (a) a detailed treatment of chemical enrichment, (b) an improved stellar feedback scheme, and (c) implements theoretical prescriptions for IMF variations. Our variable IMF realizations predict intrinsic stellar masses and mass-to-light ratios larger than those estimated from synthetic photometry assuming a universal IMF. This provides a self-consistent interpretation for the observed mismatch between photometrically inferred stellar masses of local early-type galaxies and those derived by dynamical and spectroscopic studies. At higher redshifts, the assumption of a variable IMF has a deep impact on our ability to reconstruct the evolution of the galaxy stellar mass function and the star formation history of galaxies.
Predicting the global far-infrared emission of galaxies
Authors: Dobbels Wouter , Baes Maarten
Published: June 2020

Dust absorbs stellar emission and reradiates this energy in the far-infrared (FIR). FIR observations hence give us a direct view of the dust, and allow us to study its properties. Unfortunately, FIR observations are only available for a small subset of galaxies. In this work, we estimate the global FIR emission from global UV-NIR observations. We show that a machine learning method clearly outperforms a SED modelling approach. For each galaxy, we not only predict the FIR flux across the 6 Herschel bands, but also estimate individual uncertainties. We inspect the worst predictions, and investigate how the machine learning predictor generalizes on new data. Our predictor can be used as a virtual observatory, which is especially useful now that there is still no confirmed next-generation FIR telescope.
Evolutionary Population Synthesis model with binary stars – Yunnan-II model
Authors: Zhang F. , Han Z. , Li L.
Published: June 2020

By considering a modified version of the evolutionary population synthesis (EPS) model for stellar populations (SPs) comprising binary stars, the retrieved galaxy and HII-region parameters/properties differ from the case of neglecting binary stars. The retrieved age, stellar metallicity and mass of galaxies increase (e.g. ∼ 0.2 dex when using spectral fitting algorithm), whilst the star formation rate decreases (∼0.2 dex). The radiation fields from intermediate-age SPs with binary stars could be potentially important ionizing sources in HII regions. Under this possibility, the theoretical division between star forming galaxy and AGN on the diagnostic diagrams would move towards the up-right corner and the retrieved gaseous metallicity would decrease.

Our prediction for the birth rate of binary neutron stars in SPs ranges from 10−9 to 10−6${\M {^\minus 1_\odot}} $ yr−1 when the kick velocity is from 0 to 190 km s−1.
The spectral energy distributions of active galactic nuclei
Authors: Brown M. J. I. , Duncan K. J. , Landt H. , Kirk M. , Ricci C. , Kamraj N.
Published: June 2020

Abstarct

We present ongoing work on the spectral energy distributions (SEDs) of active galactic nuclei (AGNs), derived from X-ray, ultraviolet, optical, infrared and radio photometry and spectroscopy. Our work is motivated by new wide-field imaging surveys that will identify vast numbers of AGNs, and by the need to benchmark AGN SED fitting codes. We have constructed 41 SEDs of individual AGNs and 80 additional SEDs that mimic Seyfert spectra. All of our SEDs span 0.09 to 30μm, while some extend into the X-ray and/or radio. We have tested the utility of the SEDs by using them to generate AGN photometric redshifts, and they outperform SEDs from the prior literature, including reduced redshift errors and flux density residuals.
Spatially resolved dust-to-gas mass ratios in nearby galaxies
Authors: Solís-Castillo Basilio , Albrecht Marcus
Published: June 2020

We analyse the dust-to-gas mass ratio (DGR) in nearby galaxies on kiloparsec scales. We focus on their dependence on metallicity and the CO-to-H2 conversion factor, αco. We use a sample of 25 nearby galaxies from SINGS and combine our data with CO (2-1) and H I observations from the HERACLES and THINGS surveys. We implement a Hierarchical Bayesian method to derive the dust mass via fitting the infrared data from 100 to 500 μm with a single modified blackbody. We find that the DGR-metallicity relation follows a power law and we study its strong dependency on the conversion factor αco. Our results indicate a strong connection between interstellar dust and gas. The resolved DGR-metallicity relation cannot be represented with a single power law. The scatter in this relation shows the strong impact of several processes that take place in every galaxy.
Challenges in modelling the rest-frame ultraviolet/optical spectra of galaxies at the high-redshift frontier
Authors: Zackrisson Erik , Vikaeus Anton
Published: June 2020

New challenges in the modelling of galaxy spectra are bound to emerge as upcoming telescopes like the James Webb Space Telescope will allow us to detect galaxies at fainter flux levels and higher redshifts than ever before. Here, we highlight three modelling problems that may become relevant for upcoming observations in the rest-frame ultraviolet/optical at the high-redshift frontier: stellar initial mass function sampling effects, Population III signatures and the leakage of ionizing radiation into the intergalactic medium.
Probing the luminous and dark matter profiles in the inner regions of a group-scale lens at z = 0.6
Authors: Tergolina Mônica , Furlanetto Cristina , Trevisan Marina
Published: June 2020

Studying the density profiles of galaxy groups offers an important insight on how large-scale structure in the Universe formed and evolved, since galaxy groups bridge the gap between individual galaxies and galaxy clusters. We aim to probe the total density profile of the galaxy group that is gravitational lensing HELMS18, a submillimeter galaxy at z = 2.39 from the Herschel’s HerMES Large Mode Survey (HELMS), by combining strong gravitational lensing with kinematics of the centrally-located galaxies and kinematics of the group members. We will use high-resolution data of HELMS18 obtained with the Atacama Large Millimeter/submillimeter Array (ALMA) and multi-object spectroscopic data of the group members from Gemini-GMOS. Our final goal is to combine these observations to probe the stellar and dark matter density profiles and to build a complete description of this galaxy group.
Spectral study of scattered light by interstellar dust grains
Authors: Sano Kei
Published: June 2020

Interstellar dust is traced by not only thermal emission but also scattered light. The scattered light spectrum observed from ultraviolet (UV) to near-infrared (IR) is useful to constrain some dust properties, such as size distribution, albedo, and composition. Milky Way Galaxy is a unique environment to observe the diffuse scattered light because we can extract it by removing the contribution of starlight. We have observed the UV to near-IR scattered light with space instruments, including Diffuse Infrared Background Experiment (DIRBE), Hubble Space Telescope (HST), and Multi-purpose Infra-Red Imaging System (MIRIS). The scattered light spectrum is marginally consistent with prediction from a recent dust model including carbonaceous and silicate grains with polycyclic aromatic hydrocarbon (PAH). Based on the MIRIS observation of a diffuse cloud, we compare the scattered light color with the dust model with or without grains larger than 1 micrometer. The result shows that the color is consistent with the model without the large grains, which is consistent with recent simulations of dust growth in low-density regions. However, some observations have shown the spectral excess at ∼ 0.6 micrometer wavelength, suggesting the presence of extended red emission (ERE) which cannot be explained by the conventional dust model.
Modelling the emission of passive galaxy candidates at z∼3
Authors: D’Eugenio C. , Daddi E. , Gobat R. , Strazzullo V. , Jin S.
Published: June 2020

Early-type galaxies (ETGs) are of crucial importance to trace back the galaxy mass assembly across cosmic time, yet their formation and quenching remain remarkably elusive. The discoveries of massive, dead galaxies at ever-growing redshifts provided compelling evidence to push their formation up to redshift > 4–5 when the Universe was barely 1 Gyr old. In this talk I will present our results on the ages of a new sample of ETGs at z ∼ 3, built by exploiting HST WFC3/G141 rest-frame optical/near-UV grism spectroscopy to study the nature of 10 passive galaxy candidates at 2.5 < z < 3.5 in COSMOS.

This work is part of a PhD project aimed at quantifying the parent space density of distant genuine passive galaxies. I will also discuss the importance of multi-wavelength data in clarifying the degree of contamination by dusty star-forming galaxies affecting the color selection.
Panchromatic study of the first galaxies in cosmological simulations
Authors: Yajima Hidenobu , Arata Shohei , Abe Makito , Nagamine Kentaro
Published: June 2020

Recent discoveries of high-redshift galaxies have revealed the diversity of their physical properties, from normal star-forming galaxies to starburst galaxies. To understand the properties of these observed galaxies, it is crucial to understand the star formation (SF) history, and the radiation properties associated with the SF activity. Here we present the results of cosmological hydrodynamic simulations with zoom-in initial conditions, and show the formation of the first galaxies and their evolution towards observable galaxies at z = 6. In addition, we show their multi-wavelength radiative properties. We find that star formation occurs intermittently due to supernova (SN) feedback at z > 10, and their radiation properties rapidly change with time. We suggest that the first galaxies are bright at UV wavelengths just after the starburst phase, and become extended Lyman-alpha sources. We also show that massive galaxies cause dusty starburst and become bright at infrared wavelengths.
Exploring the star formation histories of galaxies in different environments from MaNGA spectra
Authors: Argudo-Fernández Maria , Boquien Médéric , Shen Shiyin , Yuan Fangting , Yin Jun , Chang Ruixiang , Hao Lei
Published: June 2020

The star formation history (SFH) of galaxies allow us to investigate when galaxies formed their stars and assembled their mass. We can constrain the SFH with high level of precision from galaxies with resolved stellar populations, since we are able to discriminate between stars of different ages from the spectrum they emit. However, the relative importance of secular evolution (nature) over nurture is not yet clear, and separating the effects of interaction-driven evolution in the observed galaxy properties is not trivial. The aim of this study is to use MaNGA (Mapping Nearby Galaxies at APO) Integral Field Unit (IFU) data, in combination with multi-wavelength data, to constrain the SFH of nearby isolated galaxies. We present here the new techniques we are developing to constrain the SFH with high level of precision from Spectral Energy Distribution (SED) fitting. This study is part of a China-Chile collaboration program where we are applying these new techniques to investigate how galaxies formed and evolve in different environments.
A new galaxy Spectral Energy Distribution model with the evolution of dust consistent with chemical evolution
Authors: Nishida Kazuki Y. , Takeuchi Tsutomu T. , Nagata Takuma , Asano Ryosuke S. , Inoue Akio K.
Published: June 2020

The spectral energy distribution (SED) model should treat the evolution of a galaxy from its birth. Dust in galaxies affects the formation and evolution of galaxies in various ways. For example, dust grains scatter and absorb stellar emitted ultraviolet (UV) photons and re-emit the radiation at infrared (IR) wavelengths. In this work, we construct a galaxy SED model based on our dust evolution model (Asano et al. 2013a,b, 2014) with a rigorous treatment of the chemical evolution. To reduce the computational cost, we adopt mega-grain approximation (MGA; (MGA; Inoue, 2005). MGA regards a high density dusty region as a huge size (10 pc) dust grain for calculating dust scattering. In this approximation, we can solve the radiative transfer easily and provide SEDs and attenuation curves of galaxies. This model can be used to fit any galaxy in the wavelength range of 10 nm-3 mm.
A historical overview of galaxy surveys
Authors: Okamura Sadanori
Published: June 2020

Astronomy has changed from data-starving science to data-flooding science about 20 years ago due to advances of observational technology in all the wavelength regimes of electromagnetic waves. This paper gives a historical overview of galaxy surveys. We start from the impact of the technology development. Then, old imaging surveys and redshift surveys based on photography, especially using Schmidt telescopes, in the era of data-starving science are described in some detail. Several features of modern surveys are given and two highlights obtained from the exploitation of modern galaxy surveys are introduced.
Gender and Political Leadership in a Time of COVID
Authors: Johnson Carol , Williams Blair
Published: June 2020

The COVID-19 pandemic has undermined the division between the private sphere of the home and the public sphere of politics that has traditionally disadvantaged women political leaders. Whereas male political leaders historically drew on their traditional role as the male head of household to display forms of masculine protectionism toward citizens, women leaders are now able to draw on their traditional motherly role—for example, as the member of the household who traditionally cares for the sick—to display forms of feminine protectionism. As a result, international women leaders have managed to leverage women's role in the home to their advantage in the political sphere. Significantly, an appreciation of traditionally feminine attributes in women political leaders has been displayed in much media coverage, providing more favorable coverage of female political leaders than was previously the case.
Improving CBT supervision. Four years of implementing NES Specialist Supervision Training for CBT in Scotland
Authors: O’Neill Nathan , Albiston Mairi , Ferguson Sandra , Nicklas Leeanne
Published: June 2020

NHS Education for Scotland (NES) plays a lead role in training the NHS Psychological Therapies workforce across Scotland. Ferguson et al. (2016) outlined the challenges, opportunities and proposed evaluation of the NES Specialist Supervision Training in Cognitive Behavioural Therapy (NESSST-CBT). The aims of the training were to provide an evidence-based, flexible and learner-focused training in CBT specific supervision competencies. This paper will provide an update on the evaluation of the training using Kirkpatrick’s Impact Evaluation Model (1967, 1987). Results indicate that: (1) delegates rated the training experience positively in various ways; (2) delegates described increases in their confidence and competence in using structured measures of CBT and supervision; (3) a majority of delegates completing a 3-month follow-up questionnaire described continued use of a structured CBT measure in supervision and for self-reflection; and (4) 392 psychological therapists in Scotland have now been formally trained in CBT specific supervision skills. NESSST-CBT continues to adapt and improve as a resource for staff as NES moves forward in its Digital Strategy for Scotland’s NHS and partnership staff. Further implications of this are discussed, as well as limitations of the study.

Key learning aims

(1)

Readers will be able to further understand the multi-faceted role of NHS Education for Scotland in implementing CBT supervision training in Scotland.

(2)

Readers will be able to list three key outcomes from the feedback data on 4 years of a specialist supervision blended-learning training for CBT supervision.

(3)

Readers will be able to identify three key limitations of the study and recommendations for future research.
Hepatic lipid metabolism in adult rats using early weaning models: sex-related differences
Authors: Bertasso Iala Milene , Pietrobon Carla Bruna , da Silva Beatriz Souza , Miranda Rosiane Aparecida , Bonfleur Maria Lucia , Balbo Sandra Lucinei , Manhães Alex Christian , Oliveira Elaine , de Moura Egberto Gaspar , Lisboa Patricia Cristina
Published: June 2020

Non-pharmacological early weaning (NPEW) induces liver damage in male progeny at adulthood; however, pharmacological early weaning (PEW) does not cause this dysfunction. To elucidate this difference in liver dysfunction between these two models and determine the phenotype of female offspring,de novolipogenesis, β-oxidation, very low-density lipoprotein (VLDL) export, and gluconeogenesis in both sexes were investigated in the adult Wistar rats that were weaned after a normal period of lactation (control group) or early weaned either by restriction of access to the dams’ teats (NPEW group) or by reduction of dams’ milk production with bromocriptine (PEW group). The offspring received standard diet from weaning to euthanasia (PN180). NPEW males had higher plasma triglycerides and TyG index, liver triglycerides, and cholesterol byde novolipogenesis, which leads to intracellular lipids accumulation. As expected, hepatic morphology was preserved in PEW males, but they showed increased liver triglycerides. The only molecular difference between PEW and NPEW males was in acetyl-CoA carboxylase-1 (ACC-1) and stearoyl-CoA desaturase-1 (SCD-1), which were lower in PEW animals. Both early weaning (EW) females had no changes in liver cholesterol and triglyceride contents, and the hepatic cytoarchitecture was preserved. The expression of microsomal triglyceride transfer protein was increased in both the female EW groups, which could constitute a protective factor. The changes in hepatic lipid metabolism in EW offspring were less marked in females. EW impacted in the hepatic cytoarchitecture only in NPEW males, which showed higher ACC-1 and SCD-1 when compared to the PEW group. As these enzymes are lipogenic, it could explain a worsened liver function in NPEW males.
Self-Administered Field Surveys on Sensitive Topics
Authors: Nanes Matthew , Haim Dotan
Published: June 2020

Research on sensitive topics uses a variety of methods to combat response bias on in-person surveys. Increasingly, researchers allow respondents to self-administer responses using electronic devices as an alternative to more complicated experimental approaches. Using an experiment embedded in a survey in the rural Philippines, we test the effects of several such methods on response rates and falsification. We asked respondents a sensitive question about reporting insurgents to the police alongside a nonsensitive question about school completion. We randomly assigned respondents to answer these questions either verbally, through a “forced choice” experiment, or through self-enumeration. We find that self-enumeration significantly reduced nonresponse compared to direct questioning, but find little evidence of differential rates of falsification. Forced choice yielded highly unlikely estimates, which we attribute to nonstrategic falsification. These results suggest that self-administered surveys can be effective for measuring sensitive topics on surveys when response rates are a priority.
WRF‐TEB: Implementation and Evaluation of the Coupled Weather Research and Forecasting (WRF) and Town Energy Balance (TEB) Model
Authors: Meyer D. , Schoetter R. , Riechert M. , Verrelle A. , Tewari M. , Dudhia J. , Masson V. , van Reeuwijk M. , Grimmond S.
Published: June 2020

Urban land surface processes need to be represented to inform future urban climate and building energy projections. Here, the single layer urban canopy model Town Energy Balance (TEB) is coupled to the Weather Research and Forecasting (WRF) model to create WRF‐TEB. The coupling method is described generically, implemented into software, and the code and data are released with a Singularity image to address issues of scientific reproducibility. The coupling is implemented modularly and verified by an integration test. Results show no detectable errors in the coupling. Separately, a meteorological evaluation is undertaken using observations from Toulouse, France. The latter evaluation, during an urban canopy layer heat island episode, shows reasonable ability to estimate turbulent heat flux densities and other meteorological quantities. We conclude that new model couplings should make use of integration tests as meteorological evaluations by themselves are insufficient, given that errors are difficult to attribute because of the interplay between observational errors and multiple parameterization schemes (e.g., radiation, microphysics, and boundary layer).
Exhumation of the Coyote Mountains Metamorphic Core Complex (Arizona): Implications for Orogenic Collapse of the Southern North American Cordillera
Authors: Gottardi Raphaël , McAleer Ryan , Casale Gabriele , Borel Megan , Iriondo Alexander , Jepson Gilby
Published: June 2020

A microstructural and thermochronometric analysis of the Coyote Mountains detachment shear zone provides new insight into the collapse of the southern North American Cordillera. The Coyote Mountains is a metamorphic core complex that makes up the northern end of the Baboquivari Mountains in southern Arizona. The Baboquivari Mountains records several episodes of crustal shortening and thickening and regional metamorphism, including the Late Cretaceous‐early Paleogene Laramide orogeny which is locally expressed by the Baboquivari thrust fault. Thrusting and shortening were accompanied by magmatic activity recorded by intrusion of Paleocene muscovite‐biotite‐garnet peraluminous granites such as the ~58 Ma Pan Tak Granite, interpreted as anatectic melts representing the culmination of the Laramide orogeny. Following Laramide crustal shortening, the northern end of the Baboquivari Mountains was exhumed along a top‐to‐the‐north detachment shear zone, which resulted in the formation of the Coyote Mountains metamorphic core complex. Structural and microstructural analysis show that the detachment shear zone evolved under a strong component of noncoaxial (simple shear) deformation, at deformation conditions of ~450 ± 50°C, under a differential stress of ~60 MPa, and a strain rate of 1.5 × 10−11to 5.0 × 10−13 s−1at depth of ~11–14 km. Detailed40Ar/39Ar geochronology of biotite and muscovite, in the context of the deformation conditions determined by quartz microstructures, suggests that the mylonitization associated with the formation of the Coyote Mountains metamorphic core complex started at ~29 Ma (early Oligocene). Apatite fission track ages indicate that the footwall of the Coyote Mountains metamorphic core complex experienced rapid exhumation to the upper crust by ~24 Ma. The fact that mylonitization and rapid extensional exhumation postdates Laramide thickening by ~30 Myr indicates that crustal thickness alone was insufficient to initiate extensional tectonic and required an additional driving force. The timing of mylonitization and rapid exhumation documented here and in other MCCs are consistent with the hypothesis that slab rollback and the effect of a slab window trailing the Mendocino Triple Junction have been critical in driving the development of the MCCs of the southwest.
Evaluating the Impacts of Land Cover and Soil Texture Changes on Simulated Surface Wind and Temperature
Authors: Fu Donglei , Liu Yuping , Li Haizhi , Liu Songtao , Li Bo , Thapa Samit , Yabo Stephen , Sun Xiazhong , Tang Bo , Zuo Jinxiang , Qi Hong , Tian Chongguo
Published: June 2020

In this study, Chinese Academy of Sciences land cover dataset (CAS_LC) and soil texture dataset (CAS_ST) as well as Tsinghua University land cover dataset (TU_LC) were incorporated into the Weather Research and Forecasting (WRF) model to evaluate the impacts of land cover and soil texture changes on the surface wind and air temperature as compared with outdated default datasets. Six modeling scenarios including single updating for the three new datasets, combined updating of new datasets (CAS_LC + CAS_ST, TU_LC + CAS_ST), and default datasets are designed. WRF simulations were conducted with three resolutions (9, 3, and 1 km) for the period of 14 July to 31 September 2017 over Harbin. Results of the 10‐m wind speed, 10‐m wind direction, and 2‐m air temperature (T2) were evaluated against WRF default datasets (WLS). Results show that TU_LC‐related simulations with lower mean absolute error (MAE) demonstrated the usefulness of this dataset in the wind speed simulation, while the changing soil texture exerted a limited effect on modeled wind. CAS_LC improved simulated wind direction and T2. Significant changes in the three variables were frequently induced by urban and built‐up land or water bodies related transformations. The 3‐km grid resolution was sufficient to reasonably simulate the surface winds and air temperature. The roughness length was a main factor disturbing the wind speed, while the land cover transformation was responsible for the changes in surface temperature and heat fluxes, thereby affecting T2 simulation.
Education May Increase Emissions but Mitigate Human Cost of Climate Change
Authors: Kelvey Jon
Published: June 2020

Increasing education in the developing world could lead to a modest increase in carbon emissions due to economic growth, but education could also reduce the negative impact of climate change on vulnerable populations.
Role of Reemergence in the Central North Pacific Revealed by a Mixed Layer Heat Budget Analysis
Authors: Murata Kazumichi , Kido Shoichiro , Tozuka Tomoki
Published: June 2020

Wintertime sea surface temperature (SST) anomalies that disappear in summer and recur in the following winter are known as “reemergence.” The role of reemergence in recurrent SST anomalies in an area in the central North Pacific is investigated quantitatively for the first time by conducting an online mixed layer heat budget analysis with a realistic ocean model simulation. In contrast to past studies that have emphasized the importance of vertical entrainment of subsurface temperature anomalies, it is shown that several mechanisms are operating in recurrence of SST anomalies during 1977–1999. In particular, anomalous Ekman meridional advection of the mean meridional temperature gradient induced by zonal wind stress anomalies plays an important role in many years. Also, coincidence in the sign of SST anomalies in winter and surface heat flux anomalies in the following autumn leads to recurrence of SST anomalies.
A Past Lunar Dynamo Thermally Driven by the Precession of Its Inner Core
Authors: Stys Christopher , Dumberry Mathieu
Published: June 2020

The Cassini state equilibrium associated with the precession of the Moon predicts that the mantle, fluid core, and solid inner core precess at different angles. We present estimates of the dissipation from viscous friction associated with the differential precession at the core‐mantle boundary (CMB), Qcmb, and at the inner core boundary (ICB), Qicb, as a function of the evolving lunar orbit. We focus on the latter and show that, provided the inner core was larger than 100 km, Qicb may have been as high as 1010–1011 W for most of the lunar history for a broad range of core density models. This is larger than the power required to maintain the fluid core in an adiabatic state; therefore, the heat released by the differential precession at the ICB can drive a past lunar dynamo by thermal convection. This dynamo can outlive the dynamo from precession at the CMB and may have shut off only relatively recently. Estimates of the magnetic field strength at the lunar surface are of the order of a few μT, compatible with the lunar paleomagnetic intensities recorded after 3 Ga. We further show that it is possible that a transition of the Cassini state associated with the inner core may have occurred as a result of the evolution of the lunar orbit. The heat flux associated with Qicb can be of the order of a few mW m−2, which should slow down inner core growth and be included in thermal evolution models of the lunar core.
An Observation‐Driven Approach to Improve Vegetation Phenology in a Global Land Surface Model
Authors: Kolassa Jana , Reichle Rolf H. , Koster Randal D. , Liu Qing , Mahanama Sarith , Zeng Fan‐Wei
Published: June 2020

An empirical model calibration approach is presented that aims to approximate missing biosphere processes in a global land surface model without the need for substantial model structural changes. The strategy is implemented here using the NASA Catchment‐CN land surface model and Moderate Resolution Imaging Spectroradiometer (MODIS) observations of the fraction of absorbed photosynthetically active radiation (FPAR). Existing plant functional types (PFTs) of the Catchment‐CN model are divided into three subtypes, based on the bias between the model‐simulated and MODIS‐observed FPAR. Separate sets of vegetation parameters for each subtype are then calibrated at a small number of grid cells with homogeneous, single‐PFT land cover, using MODIS FPAR reference observations from 2003 to 2009. The effectiveness of the empirical approach at improving the realism of modeled vegetation dynamics is investigated with two global model simulations for the period 2010–2016, one using the newly calibrated parameter values and the other using the original values. Globally, the calibrated parameters reduce the root mean square error (RMSE) of the modeled FPAR with respect to MODIS by 0.029 (∼10%) on average. In some regions, substantially larger RMSE reductions are achieved. RMSE reductions are primarily driven by model bias reductions, with neutral effects on the temporal correlation skill. While the empirical approach is suitable for achieving consistent model improvements, it is shown to be sensitive to the characteristics of the model error, specifically a dominance of the bias component in the case of Catchment‐CN. Ultimately, more fundamental model structural changes may be required to achieve better improvements.
An independent component analysis reveals brain structural networks related to TNF-α in drug-naïve, first-episode major depressive disorder: a source-based morphometric study
Authors: Kakeda Shingo , Watanabe Keita , Nguyen Hoa , Katsuki Asuka , Sugimoto Koichiro , Igata Natsuki , Abe Osamu , Yoshimura Reiji , Korogi Yukunori
Published: June 2020

In a previous mouse study, social defeat stress-induced microglial activation released tumor necrosis factor-α (TNF-α), leading to neuronal changes in the prefrontal cortex (PFC) and behavioral changes (anxiety). We aimed to investigate the relationship between gray-matter (GM) structural networks and serum TNF-α in patients with major depression disorder (MDD) using multivariate source-based morphometry (SBM). Forty-five first-episode and drug-naïve MDD patients and 38 healthy subjects (HSs) were recruited. High-resolution T1-weighted imaging was performed and serum TNF-α levels were measured in all MDD patients and HSs. After acquiring GM structural networks using SBM, we compared the Z-transformed loading coefficients (Z-scores) between MDD patients and HSs, and investigated the relationship between the Z-scores and the serum TNF-α levels in MDD patients. The serum TNF-α levels in MDD patients were significantly higher than those in HSs. We extracted two independent GM structural networks (the prefrontal network and the insula-temporal network) with significant differences between MDD patients and HSs (−0.305 ± 0.85 and 0.253 ± 0.82; P = 0.03 in the prefrontal network, and −0.268 ± 0.86 and 0.467 ± 0.71; P < 0.01 in the insula-temporal network). The serum TNF-α levels were significantly correlated with the Z-scores in the prefrontal network after Bonferroni correction (r = −0.419, p < 0.01); however, the correlation in the insula-temporal network was not significant (r = −0.290, p = 0.11). Elevated serum TNF-α levels in the early stage of MDD were associated with alteration of the prefrontal network.
Distinct pre-initiation steps in human mitochondrial translation
Authors: Khawaja Anas , Itoh Yuzuru , Remes Cristina , Spåhr Henrik , Yukhnovets Olessya , Höfig Henning , Amunts Alexey , Rorbach Joanna
Published: June 2020

Translation initiation in human mitochondria relies upon specialized mitoribosomes and initiation factors, mtIF2 and mtIF3, which have diverged from their bacterial counterparts. Here we report two distinct mitochondrial pre-initiation assembly steps involving those factors. Single-particle cryo-EM revealed that in the first step, interactions between mitochondria-specific protein mS37 and mtIF3 keep the small mitoribosomal subunit in a conformation favorable for a subsequent accommodation of mtIF2 in the second step. Combination with fluorescence cross-correlation spectroscopy analyses suggests that mtIF3 promotes complex assembly without mRNA or initiator tRNA binding, where exclusion is achieved by the N-terminal and C-terminal domains of mtIF3. Finally, the association of large mitoribosomal subunit is required for initiator tRNA and leaderless mRNA recruitment to form a stable initiation complex. These data reveal fundamental aspects of mammalian protein synthesis that are specific to mitochondria.
Spontaneously separated intermetallic Co3Mo from nanoporous copper as versatile electrocatalysts for highly efficient water splitting
Authors: Shi Hang , Zhou Yi-Tong , Yao Rui-Qi , Wan Wu-Bin , Ge Xin , Zhang Wei , Wen Zi , Lang Xing-You , Zheng Wei-Tao , Jiang Qing
Published: June 2020

Developing robust nonprecious electrocatalysts towards hydrogen/oxygen evolution reactions is crucial for widespread use of electrochemical water splitting in hydrogen production. Here, we report that intermetallic Co3Mo spontaneously separated from hierarchical nanoporous copper skeleton shows genuine potential as highly efficient electrocatalysts for alkaline hydrogen/oxygen evolution reactions in virtue of in-situ hydroxylation and electro-oxidation, respectively. The hydroxylated intermetallic Co3Mo has an optimal hydrogen-binding energy to facilitate adsorption/desorption of hydrogen intermediates for hydrogen molecules. Associated with high electron/ion transport of bicontinuous nanoporous skeleton, nanoporous copper supported Co3Mo electrodes exhibit impressive hydrogen evolution reaction catalysis, with negligible onset overpotential and low Tafel slope (~40 mV dec−1) in 1 M KOH, realizing current density of −400 mA cm−2 at overpotential of as low as 96 mV. When coupled to its electro-oxidized derivative that mediates efficiently oxygen evolution reaction, their alkaline electrolyzer operates with a superior overall water-splitting output, outperforming the one assembled with noble-metal-based catalysts.
Association between ambient temperature and hypertensive disorders in pregnancy in China
Authors: Xiong Tao , Chen Peiran , Mu Yi , Li Xiaohong , Di Baofeng , Li Jierui , Qu Yi , Tang Jun , Liang Juan , Mu Dezhi
Published: June 2020

Hypertensive disorders in pregnancy (HDPs) are leading perinatal diseases. Using a national cohort of 2,043,182 pregnant women in China, we evaluated the association between ambient temperatures and HDP subgroups, including preeclampsia or eclampsia, gestational hypertension, and superimposed preeclampsia. Under extreme temperatures, very cold exposure during preconception (12 weeks) increases odds of preeclampsia or eclampsia and gestational hypertension. Compared to preconception, in the first half of pregnancy, the impact of temperature on preeclampsia or eclampsia and gestational hypertension is opposite. Cold exposure decreases the odds, whereas hot exposure increases the odds. Under average temperatures, a temperature increase during preconception decreases the risk of preeclampsia or eclampsia and gestational hypertension. However, in the first half of pregnancy, temperature is positively associated with a higher risk. No significant association is observed between temperature and superimposed preeclampsia. Here we report a close relationship exists between ambient temperature and preeclampsia or eclampsia and gestational hypertension.
Publisher Correction: Nucleation-controlled growth of superior lead-free perovskite Cs3Bi2I9 single-crystals for high-performance X-ray detection
Authors: Zhang Yunxia , Liu Yucheng , Xu Zhuo , Ye Haochen , Yang Zhou , You Jiaxue , Liu Ming , He Yihui , Kanatzidis Mercouri G. , Liu Shengzhong
Published: June 2020

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Contextual centrality: going beyond network structure
Authors: Leng Yan , Sella Yehonatan , Ruiz Rodrigo , Pentland Alex
Published: June 2020

Centrality is a fundamental network property that ranks nodes by their structural importance. However, the network structure alone may not predict successful diffusion in many applications, such as viral marketing and political campaigns. We propose contextual centrality, which integrates structural positions, the diffusion process, and, most importantly, relevant node characteristics. It nicely generalizes and relates to standard centrality measures. We test the effectiveness of contextual centrality in predicting the eventual outcomes in the adoption of microfinance and weather insurance. Our empirical analysis shows that the contextual centrality of first-informed individuals has higher predictive power than that of other standard centrality measures. Further simulations show that when the diffusion occurs locally, contextual centrality can identify nodes whose local neighborhoods contribute positively. When the diffusion occurs globally, contextual centrality signals whether diffusion may generate negative consequences. Contextual centrality captures more complicated dynamics on networks than traditional centrality measures and has significant implications for network-based interventions.
Narrow-band hard-x-ray lasing with highly charged ions
Authors: Lyu Chunhai , Cavaletto Stefano M. , Keitel Christoph H. , Harman Zoltán
Published: June 2020

A scheme is put forward to generate fully coherent x-ray lasers based on population inversion in highly charged ions, created by fast inner-shell photoionization using broadband x-ray free-electron-laser (XFEL) pulses in a laser-produced plasma. Numerical simulations based on the Maxwell–Bloch theory show that one can obtain high-intensity, femtosecond x-ray pulses of relative bandwidths Δω/ω = 10−5–10−7, by orders of magnitude narrower than in x-ray free-electron-laser pulses for discrete wavelengths down to the sub-ångström regime. Such x-ray lasers can be applicable in the study of x-ray quantum optics and metrology, investigating nonlinear interactions between x-rays and matter, or in high-precision spectroscopy studies in laboratory astrophysics.
Maternal plasma metabolic markers of neonatal adiposity and associated maternal characteristics: The GUSTO study
Authors: Chia Ai-Ru , de Seymour Jamie V. , Wong Gerard , Sulek Karolina , Han Ting-Li , McKenzie Elizabeth J. , Aris Izzuddin M. , Godfrey Keith M. , Yap Fabian , Tan Kok Hian , Shek Lynette Pei-Chi , Lee Yung Seng , Kramer Michael S. , Karnani Neerja , Chong Mary Foong-Fong , Baker Philip N.
Published: June 2020

Infant adiposity may be related to later metabolic health. Maternal metabolite profiling reflects both genetic and environmental influences and allows elucidation of metabolic pathways associated with infant adiposity. In this multi-ethnic Asian cohort, we aimed to (i) identify maternal plasma metabolites associated with infant adiposity and other birth outcomes and (ii) investigate the maternal characteristics associated with those metabolites. In 940 mother-offspring pairs, we performed gas chromatography-mass spectrometry and identified 134 metabolites in maternal fasting plasma at 26–28 weeks of gestation. At birth, neonatal triceps and subscapular skinfold thicknesses were measured by trained research personnel, while weight and length measures were abstracted from delivery records. Gestational age was estimated from first-trimester dating ultrasound. Associations were assessed by multivariable linear regression, with p-values corrected using the Benjamini-Hochberg approach. At a false discovery rate of 5%, we observed associations between 28 metabolites and neonatal sum of skinfold thicknesses (13 amino acid-related, 4 non-esterified fatty acids, 6 xenobiotics, and 5 unknown compounds). Few associations were observed with gestational duration, birth weight, or birth length. Maternal ethnicity, pre-pregnancy BMI, and diet quality during pregnancy had the strongest associations with the specific metabolome related to infant adiposity. Further studies are warranted to replicate our findings and to understand the underlying mechanisms.
Whole genome sequence analysis reveals genetic structure and X-chromosome haplotype structure in indigenous Chinese pigs
Authors: Tong Xiong , Hou Lianjie , He Weiming , Mei Chugang , Huang Bo , Zhang Chi , Hu Chingyuan , Wang Chong
Published: June 2020

Chinese indigenous pigs exhibit considerable phenotypic diversity, but their population structure and the genetic basis of agriculturally important traits need further exploration. Here, we sequenced the whole genomes of 24 individual pigs representing 22 breeds distributed throughout China. For comparison with European and commercial breeds (one pig per breed), we included seven published pig genomes with our new genomes for analyses. Our results showed that breeds grouped together based on morphological classifications are not necessarily more genetically similar to each other than to breeds from other groups. We found that genetic material from European pigs likely introgressed into five Chinese breeds. We have identified two new subpopulations of domestic pigs that encompass morphology-based criteria in China. The Southern Chinese subpopulation comprises the classical South Chinese Type and part of the Central China Type. In contrast, the Northern Chinese subpopulation comprises the North China Type, the Lower Yangtze River Basin Type, the Southwest Type, the Plateau Type, and the remainder of the Central China Type. Eight haplotypes and two recombination sites were identified within a conserved 40.09 Mb linkage-disequilibrium (LD) block on the X chromosome. Potential candidate genes (LEPR, FANCC, COL1A1, and PCCA) influencing body size were identified. Our findings provide insights into the phylogeny of Chinese indigenous pig breeds and benefit gene mining efforts to improve major economic traits.
Clinical relevance and functional significance of cell-free microRNA-1260b expression profiles in infiltrative myxofibrosarcoma
Authors: Morita Takuya , Fujiwara Tomohiro , Yoshida Aki , Uotani Koji , Kiyono Masahiro , Yokoo Suguru , Hasei Joe , Kunisada Toshiyuki , Ozaki Toshifumi
Published: June 2020

Infiltrative tumor growth into adjacent soft tissues is a major cause of the frequent recurrence and tumor-related death of myxofibrosarcoma (MFS), but no useful biomarkers reflecting tumor burden and infiltrative growth are available. While emerging evidence suggests a diagnostic and functional role of extracellular/circulating microRNA (miRNA) in various malignant diseases, their significance in MFS patients remains unknown. Global miRNA profiling identified four upregulated miRNAs in MFS patient sera and culture media of MFS cells. Among these, serum miR-1260b level was significantly upregulated in patient serum discriminating from healthy individuals and closely correlated with clinical status and tumor dynamics in MFS-bearing mice. In addition, high miR-1260b expression in serum was correlated with radiological tail-like patterns, characteristic of the infiltrative MFS. The extracellular miR-1260b was embedded in tumor-derived extracellular vesicles (EVs) and promoted cellular invasion of MFS through the downregulation of PCDH9 in the adjacent normal fibroblasts. Collectively, circulating miR-1260b expression may represent a novel diagnostic target for tumor monitoring of this highly aggressive sarcoma. Moreover, EV-miR-1260b could act as a transfer messenger to adjacent cells and mediate the infiltrative growth of MFS, providing new insights into the mechanism of infiltrative nature via crosstalk between tumor cells and their microenvironment.
Annexin A5 prevents amyloid-β-induced toxicity in choroid plexus: implication for Alzheimer’s disease
Authors: Bartolome Fernando , Krzyzanowska Agnieszka , de la Cueva Macarena , Pascual Consuelo , Antequera Desiree , Spuch Carlos , Villarejo-Galende Alberto , Rabano Alberto , Fortea Juan , Alcolea Daniel , Lleo Alberto , Ferrer Isidro , Hardy John , Abramov Andrey Y. , Carro Eva
Published: June 2020

In Alzheimer’s disease (AD) amyloid-β (Aβ) deposits may cause impairments in choroid plexus, a specialised brain structure which forms the blood–cerebrospinal fluid (CSF) barrier. We previously carried out a mass proteomic-based study in choroid plexus from AD patients and we found several differentially regulated proteins compared with healthy subjects. One of these proteins, annexin A5, was previously demonstrated implicated in blocking Aβ-induced cytotoxicity in neuronal cell cultures. Here, we investigated the effects of annexin A5 on Aβ toxicity in choroid plexus. We used choroid plexus tissue samples and CSF from mild cognitive impairment (MCI) and AD patients to analyse Aβ accumulation, cell death and annexin A5 levels compared with control subjects. Choroid plexus cell cultures from rats were used to analyse annexin A5 effects on Aβ-induced cytotoxicity. AD choroid plexus exhibited progressive reduction of annexin A5 levels along with progressive increased Aβ accumulation and cell death as disease stage was higher. On the other hand, annexin A5 levels in CSF from patients were found progressively increased as the disease stage increased in severity. In choroid plexus primary cultures, Aβ administration reduced endogenous annexin A5 levels in a time-course dependent manner and simultaneously increased annexin A5 levels in extracellular medium. Annexin A5 addition to choroid plexus cell cultures restored the Aβ-induced impairments on autophagy flux and apoptosis in a calcium-dependent manner. We propose that annexin A5 would exert a protective role in choroid plexus and this protection is lost as Aβ accumulates with the disease progression. Then, brain protection against further toxic insults would be jeopardised.