bluuebunny/crossref_metadata_2025 huggingface dataset:
The impact of preoperative frailty on perioperative neurocognitive disorders in elderly patients: A systematic review and meta-analysis
Authors: Zhao Shan , Wang Bei , Liu Meinv , Yu Dongdong , Li Jianli
Published: July 2024

Background:

Perioperative neurocognitive disorders (PNDs) were the most common complication in elderly patients undergoing surgery. Early identification of risk factors for PNDs and implementation of preventive measures were critical to improve prognosis. We performed this systematic review and meta-analysis to explore the impact of preoperative frailty on PNDs in elderly surgical patients.

Materials and Methods:

Systematic searches were performed in PubMed, Embase, and Web of Science. A fixed-effect model in RevMan5.3 software was conducted due to the low heterogeneity. The potential risk bias was assessed through Funnel plot and Egger’s test. Sensitivity analysis was used to examine the robustness of the outcomes.

Results:

Sixteen cohort studies enrolling 4805 elderly patients were qualified for meta-analysis. Pooled results showed that preoperative frailty was linked to the development of PNDs (pooled odds ratio [OR]: 2.40, 95% confidence interval [CI]: 2.05–2.80, P < 0.001) without obvious heterogeneity (P = 0.19, I
2 = 22%). Subgroup analyses revealed that the correlation between preoperative frailty and PNDs was more remarkable in prospective cohort studies (OR: 3.11, 95% CI: 2.47–3.91, P < 0.001) compared to retrospective cohort studies (OR: 1.94, 95% CI: 1.57–2.39, P < 0.001; test for subgroup difference, P = 0.003). In addition, the correlation in patients with cardiac surgery (OR: 3.38, 95% CI: 2.44–4.68, P < 0.001) was more noticeable than noncardiac surgery (OR: 2.17, 95% CI: 1.82–2.59, P < 0.001; test for subgroup difference P = 0.02).

Conclusion:

Our results demonstrated that preoperative frailty was independently associated with PNDs in geriatric patients undergoing elective surgery.
Resting-state brain network remodeling after different nerve reconstruction surgeries: a functional magnetic resonance imaging study in brachial plexus injury rats
Authors: Xiang Yunting , Xing Xiangxin , Hua Xuyun , Zhang Yuwen , Xue Xin , Wu Jiajia , Zheng Mouxiong , Wang He , Xu Jianguang
Published: July 2024

JOURNAL/nrgr/04.03/01300535-202505000-00031/figure1/v/2024-07-28T173839Z/r/image-tiff

Distinct brain remodeling has been found after different nerve reconstruction strategies, including motor representation of the affected limb. However, differences among reconstruction strategies at the brain network level have not been elucidated. This study aimed to explore intra-network changes related to altered peripheral neural pathways after different nerve reconstruction surgeries, including nerve repair, end-to-end nerve transfer, and end-to-side nerve transfer. Sprague–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight: no nerve repair, grafted nerve repair, phrenic nerve end-to-end transfer, and end-to-side transfer with a graft sutured to the anterior upper trunk. Resting-state brain functional magnetic resonance imaging was obtained 7 months after surgery. The independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the component. Alterations in intra-network resting-state functional connectivity were compared among the groups. Target muscle reinnervation was assessed by behavioral observation (elbow flexion) and electromyography. The results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural pathway. Nerve repair was related to enhanced connectivity within the sensorimotor network, while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor representation. The thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve transfer. Brain areas related to cognition and emotion were enhanced after end-to-side nerve transfer. Our study revealed important brain networks related to different nerve reconstructions. These networks may be potential targets for enhancing motor recovery.
Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin
Authors: Zheng Meifeng , Zhang Borui , Yau Sonata S Y , So Kwok-Fai , Zhang Li , Ou Haining
Published: July 2024

JOURNAL/nrgr/04.03/01300535-202505000-00027/figure1/v/2024-07-28T173839Z/r/image-tiff

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug therapy. Physical exercise enhances neurogenesis and synaptogenesis, and has been widely used for functional rehabilitation after stroke. In this study, we determined whether exercise training before disease onset can alleviate the severity of cerebral ischemia. We also examined the role of exercise-induced circulating factors in these effects. Adult mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery occlusion. We found that this exercise pre-conditioning strategy effectively attenuated brain infarct area, inhibited gliogenesis, protected synaptic proteins, and improved novel object and spatial memory function. Further analysis showed that circulating adiponectin plays a critical role in these preventive effects of exercise. Agonist activation of adiponectin receptors by AdipoRon mimicked the effects of exercise, while inhibiting receptor activation abolished the exercise effects. In summary, our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.
The complex effects of miR-146a in the pathogenesis of Alzheimer’s disease
Authors: Long Yunfan , Liu Jiajia , Wang Yu , Guo Haidong , Cui Guohong
Published: July 2024

Alzheimer’s disease is a neurodegenerative disorder characterized by cognitive dysfunction and behavioral abnormalities. Neuroinflammatory plaques formed through the extracellular deposition of amyloid-β proteins, as well as neurofibrillary tangles formed by the intracellular deposition of hyperphosphorylated tau proteins, comprise two typical pathological features of Alzheimer’s disease. Besides symptomatic treatment, there are no effective therapies for delaying Alzheimer’s disease progression. MicroRNAs (miR) are small, non-coding RNAs that negatively regulate gene expression at the transcriptional and translational levels and play important roles in multiple physiological and pathological processes. Indeed, miR-146a, a NF-κB-regulated gene, has been extensively implicated in the development of Alzheimer’s disease through several pathways. Research has demonstrated substantial dysregulation of miR-146a both during the initial phases and throughout the progression of this disorder. MiR-146a is believed to reduce amyloid-β deposition and tau protein hyperphosphorylation through the TLR/IRAK1/TRAF6 pathway; however, there is also evidence supporting that it can promote these processes through many other pathways, thus exacerbating the pathological manifestations of Alzheimer’s disease. It has been widely reported that miR-146a mediates synaptic dysfunction, mitochondrial dysfunction, and neuronal death by targeting mRNAs encoding synaptic-related proteins, mitochondrial-related proteins, and membrane proteins, as well as other mRNAs. Regarding the impact on glial cells, miR-146a also exhibits differential effects. On one hand, it causes widespread and sustained inflammation through certain pathways, while on the other hand, it can reverse the polarization of astrocytes and microglia, alleviate neuroinflammation, and promote oligodendrocyte progenitor cell differentiation, thus maintaining the normal function of the myelin sheath and exerting a protective effect on neurons. In this review, we provide a comprehensive analysis of the involvement of miR-146a in the pathogenesis of Alzheimer’s disease. We aim to elucidate the relationship between miR-146a and the key pathological manifestations of Alzheimer’s disease, such as amyloid-β deposition, tau protein hyperphosphorylation, neuronal death, mitochondrial dysfunction, synaptic dysfunction, and glial cell dysfunction, as well as summarize recent relevant studies that have highlighted the potential of miR-146a as a clinical diagnostic marker and therapeutic target for Alzheimer’s disease.
Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss
Authors: Chen Xihang , Chen Zhifeng , Li Menghua , Guo Weiwei , Yuan Shuolong , Xu Liangwei , Lin Chang , Shi Xi , Chen Wei , Yang Shiming
Published: July 2024

JOURNAL/nrgr/04.03/01300535-202505000-00030/figure1/v/2024-07-28T173839Z/r/image-tiff

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory dysfunction. However, there are currently no effective pharmacological interventions for patients with noise-induced hearing loss. Here, we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss, and elucidate its underlying regulatory mechanisms. We established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 dB for 4 hours. We found that tranylcypromine treatment led to the upregulation of Sestrin2 (SESN2) and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with tranylcypromine. The noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click, 4, 8, and 16 kHz frequencies compared with the noise exposure group treated with saline. These findings indicate that tranylcypromine treatment resulted in increased SESN2, light chain 3B, and lysosome-associated membrane glycoprotein 1 expression after noise exposure, leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3, thereby reducing noise-induced hair cell loss. Additionally, immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy pathway. Tranylcypromine treatment also reduced the production of NOD-like receptor family pyrin domain-containing 3 (NLRP3) production. In conclusion, our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2, which induced autophagy, thereby restricting NLRP3-related inflammasome signaling, alleviating cochlear hair cell loss, and protecting hearing function. These findings suggest that inhibiting lysine-specific demethylase 1 is a potential therapeutic strategy for preventing hair cell loss and noise-induced hearing loss.
Caracterización de la gestión en convivencia escolar a nivel intermedio en Chile
Authors: Ascorra Paula , Cárdenas Mancilla Karen
Published: July 2024

En el ámbito internacional, el rol del nivel intermedio en la gestión de la convivencia escolar ha sido escasamente estudiado. En Chile, los estudios han expuesto una gestión incipiente y desprovista de condiciones laborales que favorezcan su desarrollo. Este estudio se propuso caracterizar la gestión de la convivencia escolar a nivel intermedio en dos aspectos relevados por la literatura: cualidad y cantidad del recurso humano, y roles y funciones en convivencia escolar. La investigación fue descriptiva e inferencial. Participaron 678 encargados del nivel intermedio de cinco dependencias administrativas. Los resultados muestran que las características en la calidad y cantidad del recurso humano difieren según el tipo de dependencia. Sin embargo, las funciones y acciones implementadas en convivencia escolar tienden a ser similares. Se discuten las condiciones de inequidad en las que desempeñan sus funciones y el efecto de las políticas de accountability sobre su gestión.
Desarrollo de la competencia de liderazgo en la educación superior: perspectivas de estudiantes, egresados y docentes en una universidad chilena
Authors: Sotomayor Soloaga Pedro , Burgos Videla Carmen , Martínez Nehme Francisco , Caradeuc Nicolás
Published: July 2024

En la actualidad, el liderazgo destaca como una competencia esencial, requerida tanto por la sociedad como por el mercado laboral. Si bien la Universidad de Atacama demuestra su compromiso con el desarrollo del liderazgo al integrarlo como competencia genérica en su Modelo Educativo, subsisten interrogantes respecto a cómo se desarrolla esta competencia y cómo se asegura su aplicabilidad en el ámbito profesional. Con un enfoque cualitativo, este estudio exploró las percepciones de estudiantes, egresados y docentes, con el propósito de comprender el proceso de formación del liderazgo. Los resultados subrayan la relevancia de la comunicación empática, el rol del profesorado y la necesidad de una formación más holística en liderazgo. Se concluye que las instituciones de educación superior deben revisar y mejorar los programas formativos, estableciendo alianzas con organizaciones para brindar experiencias prácticas a los estudiantes que les permita mejorar la formación del liderazgo.
On the metaphysics of $\mathbb{F}_{1}$
Authors: Connes Alain , Consani Caterina
Published: July 2024

In the present paper, dedicated to Yuri Manin, we investigate the general notion of rings of

\mathbb{S}[\mu_{n,+}]

-polynomials and relate this concept to the known notion of number systems. The Riemann–Roch theorem for the ring

\mathbb{Z}

of the integers that we obtained recently uses the understanding of

\mathbb{Z}

as a ring of polynomials

\mathbb{S}[X]

in one variable over the absolute base

\mathbb{S}

, where

1+1=X+X^{2}

. The absolute base

\mathbb{S}

(the categorical version of the sphere spectrum) thus turns out to be a strong candidate for the incarnation of the mysterious

\mathbb{F}_{1}

.
Tocilizumab as a Potential Treatment Option for Severe Fever with Thrombocytopenia Syndrome
Authors: Kim Misun , Yoo Jeong Rae , Kim Young Ree , Heo Sang Taek
Published: July 2024

Severe fever with thrombocytopenia syndrome (SFTS) is a viral hemorrhagic disease prevalent in Asian countries with a fatality rate of approximately 10% to 30%. However, there are currently no definitive treatments for reducing mortality. Variable management strategies have been attempted to reduce the mortality rate associated with SFTS. Tocilizumab is an inhibitor of interleukin-6 and is used to treat rheumatologic and viral infectious diseases. This article presents two cases of SFTS in older patients with neurological symptoms and explores the potential use of tocilizumab, as a treatment option. The patient showed improved consciousness and clinical outcomes after tocilizumab administration. This report describes this condition and reviews related literature.
Effects of infill wall thickness and arrangement on the seismic performance of the reinforced concrete frames
Authors: Akcan Esra , Güneyisi Esra Mete
Published: July 2024

In this study, it is aimed to investigate the seismic behavior of the reinforced concrete (RC) frames with and without infill walls having different thickness and arrangement. To this, 3, 4, 5, 6, and 7 story RC frames consisting of 4 and 5 bays were studied. Infill walls were introduced into the frame models by considering four different arrangements over the height of the structure such as full infill frame (FIF), full infill frame with soft story (FI-SSF), exterior bay infill frame (EBIF), and exterior bay infill frame with soft story (EBI-SSF). For each case, four different infill wall thicknesses of 10 to 25 cm were taken into account. Thus, a total of 170 different frame models with and without infill walls were investigated thorough nonlinear static analysis method by means of SAP 2000 program. The infill panels were modeled by utilizing equivalent diagonal compression strut. As a result of the analyses, the capacity curves of the structures, maximum base shear force, initial stiffness, and mechanism of the plastic hinge formation in the structures were determined and comparatively discussed. It was observed that both wall thickness and arrangement have significant impact on the lateral load carrying capacity and hinge formation of the case studied structures, on the other hand, with their compatible choice the greatest seismic performance could be achieved.
A CLINICAL COMPARATIVE STUDY TO ASSESS THE EFFECTIVENESS OF
'TRAYODASHANGGUGGULU','RASNADI KWATH' AND 'NIRGUNDIPATRAPINDASWEDA' IN THE MANAGEMENT OF ‘KATIGATAVATA ROGA’ (LUMBER
SPONDYLOSIS)."
Authors: Jangid Usha , Gupta Monu
Published: July 2024

Now-a-days people are busy in their routine work and unaware to maintain their health. Consequently,
they are being susceptible to various kinds of lifestyle disorders. The Disease Katigata vata Roga is one of the
known crippling disorders claiming loss of daily activities of the affected person. To arrest the vatajvyadhi as
like Asthigatavata Ayurveda has taken the fore most place in the management of like ‘Katigatavata Roga’.
which can be correlated with Lumber spondylosis due to its clinical appearance. Due to wide spectrum of disease, much prevalence in the society and lack of effective medicament, the disease is being chosen for the study.
The study was conducted in 20 clinically diagnosed patients of ‘Katigatavata Roga’.These patients are divided
into two groups of 10 patients each . In this study10 Patients were treated by Trayodashangguggulu2 tab.(each
tab. Of 500mg) three times in a day with lukewarm water and Rasnadi Kwath 50 ml two times in a day for 30
days and other 10 patients were treated with Nirgundipatra-Pindasweda with Rasna Dashamoola Taila for 40
minutes daily once a day for 15 days. From the observations and results it can be concluded that better results
were obtained in all clinical manifestation of Katigata vataroga beside symptom of weakness on muscle on the
basis of percentage relief.
A CLINICAL STUDY ON THE EFFICACY OF JYOTISHMATYADI KALKA IN THE
MANAGEMENT OF NASHTARTAVA W.S.R TO ANOVULATION
Authors: Khan Rumeena , Jalihal Satish
Published: July 2024

Ovulation is the process of release of an oocyte from the ovarian follicle. As mentioned earlier, it occurs on day
14 of the menstrual cycle. After the description of Ashtartava, Sushruta describes the destruction of Artava, i.e.
Nashtartava, Bhavprakasha mentioned as Rajonasha, caused due to margavarodha in artavavaha srotas, by vata
and kapha. Sushruta explains the ritukala in such a manner. The first 12 days of ritukala is kapha kala that means
maturation of follicle from day 12-16 is considered pitta kala that means the rupture of follicle and release of a
secondary oocyte. Many works have been done on Nashtartava, but Jyotishmatyadi kalka, indicated by Bhavprakasha as Kusumam Janyate, is still untouched. Hence, a non-hormonal and safer method has been selected.
PANCHAKARMA- A RAY OF HOPE IN THE MANAGEMENT OF MALE INFERTILITY
Authors: N Swathi , S Desai Ananta
Published: July 2024

Infertility implies apparent failure to achieve conception by a couple of mature age, having normal coitus, during
appropriate period of menstrual cycle, regularly, atleast for one year. It develops due to faults in either of the
partner or both of them. Globally, infertility affects approximately 13% to 15% of all couples in which 20% to
30% of infertility cases, males can be solely responsible. In ayurveda acharyas explained infertility under the
sprectum of klaibya and vandhyatwa. Klaibya is a condition where a person’s inability to perform sexual act due
to difficulty in erection, non erection or flacidity of penis associated with swasa, ati sweda, which can be corealeted to erectile dysfunction. is a type of infertility where there is defect in the semen due to vitiated vata dosha.
Here is a single case study of erectile dysfunction with teratozoospermia with significant improvement in the condition. Panchakarma modalaties has given a ray of hope in such difficult cases.
MANASHILA: AN IN-DEPTH ANALYSIS THROUGH THE CLASSICAL TEXTS
Authors: Ghildiyal Rolli , Mitra Shuchi , Sharma Usha , Chand Sharma Khem
Published: July 2024

Manashila, Haratala, and Somala are significant arsenic compounds that are deeply integrated into holistic prac-tices. Among these, Manashila is revered for its versatility and efficacy in treating various ailments. Its wide-spread employment extends to addressing afflictions such as Shwasa-Kasa (respiratory disorders), Agnimandya (digestive weaknesses), Kshaya (emaciation), Anaha (abdominal distention), Jwara (fever), Krimi (parasitic in-fections), Visharoga (poisoning disorders), Raktavikara (blood disorders), and more. The present study offers a comprehensive critical review of Classical literature focusing on Manashila. Numerous classical texts of Rasa Shastra have been meticulously scrutinised to furnish an exhaustive depiction of Manashila, encompassing its Praptisthana (occurrence), Prayaya (synonyms), Vargikarana (classification), Karma (pharmacological proper-ties), Ashuddha Manashila Dosha, its Prativisha (antidote), Shodhana (purification), Marana (incineration), Matra (therapeutic dose), Chikitsiya Prayoga (therapeutic indications), Satvapatana (extraction), along with elu-cidation on artificial methods of Manashila preparation, complemented by insights into Realgar. It is crucial to emphasise that Manashila is exclusively utilised in a purified and detoxified state for internal and external thera-peutic purposes.
EFFECTIVE AYURVEDIC DRUGS FOR HYPERLIPIDEMIA : REVIEW ARTICLE
Authors: Shinde Alisha Hrushikesh
Published: July 2024

Hyperlipidemia is a condition in which blood contains an abnormally high amount of lipids i.e. fats. These factors
can accumulate and cause blockages in blood vessels. This is why having high cholesterol may increase the risk
of damaging organs that don’t receive enough blood from arteries. Life threatnening emergencies like heart attack
and brain stroke can arise from untreated chronic hyperlipidemia. Today’s sedentary lifestyle, ready to eat or instant food items, increasing use of technologies which decreases physical activities, all these factors prone for increase in abnormal lipid levels in body. Foods that have cholesterol, saturated fat, and trans fats can raise
blood cholesterol level. These include Cheese, Fried and processed foods, Ice cream, Pastries, Red meat etc. According to WHO, the global prevalence of raised total cholesterol among adults was 39% (37% for males and
40% for females) in 2008. According to a study by ICMR-INDIAB, prevalence of dyslipidemia in a large representative sample of four selected regions in India showed that 79% had abnormalities in one of the lipid parameters. Meda dhatu from Ayurveda is an entity which is correlated to lipids. Medoroga, Medodosha, Sthaulya are the
synonyms used for diseases with excessive formation and accumulation of Meda dhatu. Two main treatment modalities present in Ayurveda, Shodhan and Shaman, play an efficient role in treating this disease. So, there is a
challenge of treating the disease without interference in the daily routine of an individual. This paper specifically
throws light on meeting aforesaid needs with some effective Ayurvedic drugs possessing Medopachaka, Agnideepaka, Vatanulomaka and Rasayana properties.
MANOVIKARA IN AYURVEDA: BRIDGING MIND AND BODY
Authors: Joshi Kriti , Harjpal L.C. , Singh Shweta
Published: July 2024

In Ayurveda utmost importance is given to mental health.A person would be considered healthy when his body
and mind are in euilibrium. In Ayurveda, psychiatry unites the body, mind, and soul in which the mind-body connection is highly valued. The main cause of worsening any disease is vishada. ( Vishado Rogvardhananam). In
terms of mental health, two conditions that are very similar to depression are Avasada and Vishada. Physical imbalances can cause mental disorders, and mental illnesses can cause bodily functions to be disrupted.
MAMSAGATA VATA W.R.T MYALGIA/IDIOPATHIC MUSCULOSKELETAL PAIN IN CHILDREN: A CASE STUDY
Authors: Raju Chandramouli
Published: July 2024

Introduction: A 13-year-old male patient reported to the Outpatient Department (OPD) of Kaumarabhrithya at Shree Swaminarayan Ayurvedic College and Hospital with complaints of diffused (un-localized) severe muscle pain, slurred speech and sleeplessness from the past one year. Another associated complaint was the inability to pronounce the word ‘r’. The main complaint, though, was the muscular pain throughout the body. Though the patient was previously diagnosed and treated for pain as per the conventional science/medical hospitals, the pa-tient and his parents did not have the records. They were unable to recall the names of the medicines prescribed. At Swaminarayan Ayurvedic Hospital, he was diagnosed with Mamsagata Vata and treated with a combination of internal medications and Panchakarma procedures. Methods- The patient was treated with internal medica-tions Brahmi vati Swarnauyukta (250 mg/BD), Brahmi Gritha (5 ml/BD) and Dashamularishta (10 ml with 20 ml water/BD); Panchakarma therapies of Sarvanga Abhyanga (full body therapeutic massage therapy), Sarvanga Swedana (full body fomentation therapy) and Matra Basti (therapeutic enema with medicated oil with low quan-tity) for seven days. The primary objective was to treat Mamsagata Vata and associated symptoms with Snehana, Vatagna dravyas and Medhya rasayana. Results- The patient was treated with internal medications and Panchakarma therapies for seven days. There was a significant reduction in muscular pain and an improve-ment in sleep. No adverse effects were reported. This case study elucidates Snehana's (Matra Basti) efficacy in managing Mamsagata Vata. Discussion- The clinical data from this study suggests that Ayurvedic treatment in managing Mamsagata Vata w.r.t Myalgia/Idiopathic musculoskeletal pain in Children can provide effective re-sults.
A CASE STUDY ON THE COMBINED APPROACH OF KALABASTHI AND
RASAYANA CHIKITSA IN GRDHRASI
Authors: Rani S. R Shabna , Pai Surekha , Kiran K.
Published: July 2024

Grdhrasi is one among the vataja nanatmaja vyadhi1
, affecting the mamsa, asthi dhatus. The disease is
characterized by predominantly pain originating from the lower back (Kati) and pelvic region (Sphik Pradesha),
with pain extending down to the legs, resulting in a walking pattern reminiscent of a grdhra (vulture). Timely and
appropriate treatment is crucial for relieving pain ,improving function, preventing complication ultimately
promoting a better quality of life. A 58-year-old male patient approached to Kayachikitsa OPD Alvas Ayurveda
Medical College with the chief complaints of pain in low back region radiating to right leg for 11/2 months (pulling
type of pain) . The patient was given Ayurvedic medications along with panchakarma procedures.
Gandharvahasthadi Kashaya, Gokshuradi guggulu , Kala basthi, Rasayana medications was given . The results
were remarkable. Hence this study was taken to prove that comprehensive Ayurvedic management has remarkable
results in Grdhrasi.
AYURVEDIC MANAGEMENT IN CHRONIC STOMATITIS (I.E. MUKHAPAK) – A CLINICAL CASE STUDY
Authors: Bokade Vandana , Kombe Pooja S.
Published: July 2024

Stomatitis is an inflammatory ulcer of the mucosa of the oral cavity, which causes a burning sensation and pain.
In Ayurveda, it is mentioned as Mukhpaka. Introduction: Objective: To assess the effect of ayurvedic management on Chronic stomatitis (i.e. Mukhapaka). Methodology: Here, a 20-year male patient with complaints of Ulcer over the upper lip, severe pain and burning sensation during eating for the last two months had been diagnosed
with Stomatitis, successfully managed with simple Ayurvedic medicine and purgation therapy (virechana karma),
within Few days of treatment. Observation and result: Ayurvedic management effectively treats chronic stomatitis (i.e., Mukhapaka). Conclusion: Chronic stomatitis (i.e. Mukhapaka) can be treated with minimal medications
within a short period.
LEGAL RESPONSIBILITY FOR USING OIL FUEL ON PARTALITE DEFENSE (CASE STUDY OF DITPOLAIRUD POLDA BALI)
Authors: Arimbhawa I Gusti Kade , Nurianto Nurianto , Damanik Siti Nurmawan
Published: July 2024

The purpose of this study is to find out and analyze legal accountability and factors that affect perpetrators in the misuse of Pertalite Assignment Fuel Oil. In a five-year period, from 2019 to 2023, the Bali Regional Police Directorate handled 10 cases of misuse of Oil and Gas Fuel. The authors conclude that the absence of regulation regarding the maximum limit for the purchase of special assignment fuel with jerry cans, thus causing the Blurring of Legal Norms, so that this can cause the abuse of fuel oil. Factors such as low legal awareness and public compliance with the rules, the dominance of individual and group interests, and the lack of knowledge about applicable regulations are the main causes of the misuse.
LEGAL CERTAINTY ON BUILDING DISTRIBUTION AND CONFORMITY WITH THE DETAILED SPATING PLAN IN THE WILDLAND OF MENGWI SPECIFICALLY IN THE GREEN OPEN SPACE ZONE AND THE AGRICULTURAL ZONE (ANALYSIS OF LEGAL CERTAINTY FOR BUILDINGS THAT VIOLATE SPATIAL PLANNING)
Authors: Darmayanti Ni Putu Eka , Wiratny Ni Ketut , Sihotang Erikson
Published: July 2024

This study aims to identify and understand in depth the factors that cause development in the green open space zone and agricultural zone in Mengwi District, Badung Regency, as well as analyze the legal certainty for building owners in these zones. The research was carried out in a qualitative descriptive manner with legal interpretation and legal communication methods, which systematically prepared legal materials to be presented in the thesis entitled "Legal Certainty Against the Distribution of Buildings and Conformity with Detailed Spatial Plans in the Mengwan District Area (RDTR WP), Especially in the Green Open Space Zone and Agricultural Zone." The results show that social factors such as population growth, inheritance rights distribution system, and low interest of the younger generation in agriculture are the most important factors that affect the development and conversion of green open spaces (RTH) in this area. However, there are challenges in law enforcement such as the effectiveness of long-standing regulations and the lack of public awareness of the importance of preserving green lanes. The government and related agencies need to be more decisive in sanctioning buildings in the area to maintain green areas and agriculture as a mitigation effort in preventing land conversion. This research is expected to be a guideline for the community in using land in accordance with spatial planning, providing input for the government on the legal impact of land use transitions, and providing guidance for all stakeholders related to land use.
ANALYSIS OF HEALTHCARE QUALITY IN THE ERA OF DIGITALIZATION: CHALLENGES AND OPPORTUNITIES
Authors: Viegas Inacio Sarmento
Published: July 2024

Digitalization offers numerous opportunities to improve the quality of health services. This study aims to analyze the impact of digitalization on the health services, identify the challenges faced in the implementation of digital technology, and explore the opportunities offered by digitalization in improving the health service quality. A qualitative approach is used to understand the perspectives and experiences of patients and medical personnel towards digitalization. Quantitative analysis is carried out using descriptive and inferential statistics to identify trends and patterns in the data. Thematic analysis techniques are used to identify the main themes and categories that emerged from the interview and observation data. Digitalization has a significant impact on the quality services, both positive and negative. To maximize the benefits of the digitalization, efforts are needed to address existing challenges, including increasing access to digital technology and strengthening data security and privacy, and providing training and support for medical personnel. Further research is needed to explore how digital technology can be used to improve health services and provide recommendations to overcome existing challenges.
THE ROLE OF USER SATISFACTION IN MEDIATING THE EFFECT OF PERCEIVED EASE OF USE AND PERCEIVED USEFULNESS ON REUSE INTENTION (STUDY OF TIKET.COM USERS IN DENPASAR CITY)
Authors: Paramananda Komang Agus Sathya , Sukaatmadja I Putu Gde
Published: July 2024

The purpose of this study is to determine the influence of perception of ease of use and perception of benefits on reuse intention through user satisfaction and determine the role of user satisfaction in mediating the relationship between perceived ease and perceived usefulness and reuse intention. The research was conducted in the city of Denpasar, aimed at e-commerce users Tiket.co. The results of the t-test show that perceived ease of usage has a positive and significant effect on the reuse intention and user satisfaction of the platform users. In addition, user satisfaction is able to mediate this relationship, and is a mediator in this process.
THE INFLUENCE OF EDUCATIONAL SERVICE QUALITY AND SCHOOL IMAGE ON STUDENT SATISFACTION IN PRIVATE HIGH SCHOOL "X" BANDUNG CITY
Authors: Cecilia Stephanie , Saputra Bobby Wiryawan
Published: July 2024

This study aims to determine the influence of the quality of educational services, student satisfaction, and school image on student satisfaction at Private High School (SMA) "X" Bandung City, West Java. The population in this study is all students in grades X, XI, and XXII totaling 99 students, and 2023 alumni totaling 28 people (a total of 127 respondents). The results of the analysis and discussion were as follows: (1) The quality of education services has a positive and significant influence on the satisfaction of students at private high school with a total influence of 32.0%. (2) In addition, school image also has an important influence on students' satisfaction, which is 36.5%. (3) The school's image has also a significant positive influence on satisfaction with an overall influence of 68.5%, and it is recommended that schools provide continuous professional training and development for teachers to improve knowledge, skills, pedagogy.
THE INFLUENCE OF CITY BRANDING "SERAMBI NUSANTARA" ON TOURISTS' INTEREST AND DECISION TO VISIT IN PENAJAM PASER UTARA
Authors: Chaniago Rizal Zainuddin , Sirait Tongam
Published: July 2024

This study examines the extent to which the "Serambi Nusantara" city branding influences tourists' visiting interest and decision-making to visit Penajam Paser Utara. A sample of 400 respondents will be randomly selected using the Slovenian method to determine the sample size, and they will participate in a survey using a structured questionnaire. The findings of this research are expected to provide significant insights into the effectiveness of city branding in influencing tourist behavior and its relevance for developing improved tourism strategies in the region. The analysis results indicate that the city branding significantly affects tourists' visit interest and visit decisions with a contribution of 74.7% and 63.7%, respectively, while visit interest itself significantly influences visit decisions. This research can inform tourism marketing strategies and city branding initiatives aimed at boosting tourism in areas that may possess unique characteristics and challenges.
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Published: July 2024

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Desenvolvimento da linguagem infantil após implantação coclear: uma revisão da literatura
Authors: Barrachini Leonardo , Oliveira Brenda Machioni , Caetano Isana de Oliveira , Silva Gabriel Marques Roberto Lino e , Santos Geovana Baier dos
Published: July 2024

Introdução: Cnsiderando o transplante coclear como uma possível solução para o desenvolvimento em uma determinada população infantil com perda auditiva importante, são elencados quais os possíveis impactos no desenvolvimento da linguagem dos indivíduos, os quais foram submetidos a este implante, analisando fatores relacionados ao perfil do paciente, indicação quanto ao grau de perda auditiva e as alternativas do tratamento. Objetivo: Este artigo tem como objetivo o conhecimento sobre a melhora das habilidades auditivas em crianças e quais os impactos do desenvolvimento linguístico e educacional. Materiais, sujeitos e métodos: Para a elaboração deste artigo de revisão foram consultados artigos de revisão sistemática publicados e referenciados no SciELO e Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial no período de 2013 a 2021. Resultados e discussão: Os artigos analisados e utilizados contemplam sobre a eficácia e o prognóstico com o tratamento a partir do transplante coclear, trazendo os resultados acerca do desenvolvimento auditivo e linguístico no paciente transplantado e suas possíveis restrições.
Considerações finais: Conforme analisados, os estudos demonstram que o implante coclear detém um importante papel no desenvolvimento das crianças que são submetidas a este procedimento quando realizados de maneira precoce, apresentando desempenho semelhante quando comparado às crianças que não apresentam perda auditiva.
The Influence of Automated Harvest Robots in Japan on the Interest of TRPL IPB Students in Improving the Welfare of Agriculture
Authors: Manurung Maryetha Yovanka Leony , Kirana Sya'bani Salsi , Septia Anggraeni Ika , Ummah Khaera , Sacio Ramadhani Amelia , Fathul Mubin Ardi , Fuad Rahmatid Dhuha Muhammad , Rubina Lestari Humannisa
Published: July 2024

This study aims to examine the impact of Automated Harvesting Robots on agriculture in Japan and to investigate how the interest of TRPL IPB students in these technologies might influence agricultural innovation in Indonesia. The research evaluates how these robots have transformed agricultural practices in Japan by enhancing efficiency, reducing labour costs, and alleviating labour shortages. It also explores the potential for these advancements to stimulate agricultural innovation in Indonesia, facilitated by the engagement of TRPL IPB students. A mixed-methods approach was employed, combining an analysis of agricultural productivity and labour data from Japan with surveys and focus groups involving TRPL IPB students. This methodology comprehensively assesses the technological advancements and their implications for both Japanese and Indonesian agricultural sectors. Findings indicate that Automated Harvesting Robots have substantially improved efficiency and lowered labour costs in Japan while addressing labour shortages. These outcomes suggest that similar technologies could be beneficial if adopted in other regions. The high level of interest among TRPL IPB students reflects a readiness to integrate such innovations into Indonesian agriculture. Their feedback on the functionality of these robots offers valuable insights into their perceptions and potential barriers to technology adoption. The study highlights the critical role of technological exchange and student involvement in fostering agricultural innovation. However, limitations include potential cultural and infrastructural differences between Japan and Indonesia that may affect the direct applicability of these technologies. Future research should address these challenges and explore strategies to adapt and implement these innovations across diverse agricultural contexts effectively.
Murcs Association: A most severe form of Mayer-Rokitansky-Küster-Hauser Syndrome, case report and literature review
Authors: Rodríguez Verduzco Julio César , González Tapia José Ines , Martinez Galindo Nelly Ivette , Santos Rodríguez Alexis Eliseo , Becerril González Ana Norma Gricelda , Mancilla Hernández Fernando , Correa Castillo Martha Camila , Laurel Lujan Yaser
Published: July 2024

BACKGROUND

Mayer-Rokitansky-Küster-Hauser syndrome (MRKH) is a congenital abnormality of sexual development characterized by an aplastic or hypoplastic uterus, as well as the absence of the cervix and the upper third of the vagina. It may be limited to the reproductive tract (MRKH type 1), or in association with abnormalities of the extragenital tract, usually of renal and skeletal origin (MRKH type 2). The presence of a pattern of multiple anomalies has been described, specifically characterized by aplasia of the Müller ducts (MU), renal aplasia (R), and alterations of the cervicothoracic somite (CS), which has been called the MURCS association.

METHODOLOGY

A search was performed in the Medline database via PubMed using the following terms: “Mayer–Rokitansky–Küster–Hauser Syndrome”, “Mullerian anomalies”, “genetics of agenesis/hypoplasia of the uterus and vagina”, “uterine cervical aplasia and agenesis”, from 1979 to 2023, a total of 316 studies were found, 58 studies were selected that included women with a diagnosis of MRKH or MURCS association.

CASE REPORT

A 34-year-old woman attends a gynecologist evaluation presenting primary amenorrhea, with external genitalia with normal development, but has multiple spinal abnormalities. The image reports the absence of the uterus and the superior two-thirds of the vagina, renal aplasia, scoliosis, and cervical, thoracic, and lumbar spinal abnormalities.

CONCLUSIONS

Mullerian abnormalities are a set of abnormalities of sexual development in which the development of the uterus, fallopian tubes, and vagina are mainly affected. Within this group, there is MRKH syndrome. In these variants of GREB1L (estrogen growth regulation gene in breast cancer type 1 gene), variants have been reported in familiar cases of bilateral renal agenesis. Establishing the cause of these clinical entities is controversial, making it difficult to deny or affirm whether the atypical forms of the MRKH syndrome and the MURCS association belong to the same phenotypic spectrum originating from common or related causes or simply different entities.
The first record of the mite family Parholaspididae from Türkiye (Parasitiformes: Mesostigmata)
Authors: Özbek Hasan Hüseyin
Published: July 2024

In this study, female specimens of Gamasholaspis browningi were collected under hazelnut trees in a tea garden in Türkiye and described as a new record of the Turkish mite fauna. It was determined that this is the first representative of the family in Türkiye. In addition, an overview of the current status of the Turkish eviphidoid fauna is given.
A complementary description of Kampimodromus corylosus Kolodochka (Acari: Phytoseiidae) and a revised key for the genus Kampimodromus Nesbitt
Authors: Döker İsmail , K. Ozman-sullivan Sebahat , Sullıvan Gregory Thomas
Published: July 2024

Kampimodromus corylosus Kolodochka (Acari: Phytoseiidae), which is reported for the first time from Türkiye, is re-described and illustrated, based on female specimens collected from hazelnut (Corylus avellana L., Betulaceae). In addition, the reinstatement of K. adrianae Ferragut and Peña-Estévez as a valid species is proposed. A revised identification key for the world’s Kampimodromus Nesbitt species is also provided.
Development of Body Safety Module Among Elementary School Students: Perception of Effectiveness on SDGS
Authors: Jajuli Maizatul Najwa , Salim Sara Shakilla Mohd , Hisamudin Siti Nurfarhana , Saad Muhamad Ikhwan Mat , Rasid Salma Farhanah A. , Sharif Sharifah Norain Mohd
Published: July 2024

Objective: Sexual education for children is crucial as it aids in their understanding and appreciation of their bodies. This research aims to develop a Body Safety Module as a teaching tool for primary school students. The modules were analyzed to determine perception of usability as well as their effectiveness.
 
Methods: This study focuses on design and development research, adopting the five phases in the ADDIE model for the module development process. To evaluate the module’s effectiveness, 205 respondents were randomly chosen to complete a questionnaire. Furthermore, an additional 71 pupils participated in pre- and post-effectiveness tests. This study examined three specific aspects of validity: content validity, questionnaire validity, and the effectiveness of pre and post-test.
 
Results and conclusion: The module received extensive professional review and agreement, showing a 93.73% agreement on the validity of the content.  Meanwhile, the test of the effectiveness of the module using questionnaires reflected a validity rate of 93.3%. The questionnaire also demonstrated a high level of reliability (α = 0.766). Data analysis was performed using inferential statistics (T-test) and descriptive statistics (mean and standard deviation). When assessing student perceptions of the module, a moderate level of agreement was found across various aspects: design (M 2.67, SD 0.51), satisfaction (M 2.36, SD 0.67), and usability (M 2.69, SP 0.52). There was a significant difference in mean scores between the control and treatment groups in post-test results. In this aspect, the Body Safety Module proved more effective than traditional textbooks for students. As a result, this module is an appropriate teaching tool for elementary school students.
 
Research Implications: This module serves a broader purpose than merely a teaching tool; it is suitable for children aged from 7 to 12 years old. This early sexual education module delivers crucial knowledge and awareness, empowering children to protect their precious bodies and recognize sexual harassment instances. Gender equality is closely linked to the prevention of sexual harassment and abuse. The Body Safety Module addresses these issues by fostering awareness among children, regardless of gender, about their rights and boundaries.
Solving Construction Project Delays as SDGS: Evidence from Indonesia
Authors: Dwi Putranto Riau  , Junaidi Junaidi , Akadira Tora , Muhtarom  , Diana Bambang Agus , Madya Faizal
Published: July 2024

Objectives: For the service provider, the contract will be terminated by the Government, and it will be noted that they cannot participate in project tenders in the coming year.
This study analyzes Service Providers who need resource readiness to complete the Project Schedule to Build resilient infrastructure, promote inclusive and sustainable industrialization, and foster innovation as SDGs
 
Theoretical Framework: The theory used is project management by Kerzner (2013), cost management stages by expert Gunn (2017), and risk management to be effective by Santosa (2009).
 
Methods: The method is descriptive qualitative. Data analysis by conducting interactive analysis, data reduction steps, data presentation, and drawing conclusions or verification. 
 
Results and Discussion: This study indicates that the project work schedule must be completed according to the mutually agreed agreement letter. The Regional Government must coordinate and communicate with service providers so that they can complete the project by the Agreement, especially on blocklist sanctions against service providers and the Implementation of statutory provisions on construction services, risk management, and project financing management.
 
Conclusions: Applying the provisions of laws and regulations regarding Construction Services by implementing the terms of the agreement, apply risk management to the ad hoc project selection committee and the Public Works Department so that the risks of slow projects can be anticipated, and Implementing Funding and Time Management with resource planning with careful project cost estimation, cost budgeting, and cost control of changes to the project budget and Implement the project schedule according to the plan.