bluuebunny/crossref_metadata_2025 huggingface dataset:
Brachiopod outline and the importance of the logarithmic spiral
Authors: Aldridge Anthony E.
Published: August 2022

To a first approximation, the logarithmic spiral is a close fit to the biconvex lateral outline of three terebratellid genera from Australasia. Investigation of spiral parameters confirms the value of the biconvex morphospace of McGhee (1980), but not the method for estimating the spiral itself. Deviations from the estimated spiral are episodic and consistent with Rudwick's (1959) observations of allometry in brachiopod growth. Morphospace location is postulated to be indicative of a species' substrate and lifestyle. The logarithmic spiral offers much opportunity for gaining better understanding of external shape and its cause in articulate brachiopods.
Environmental Stewardship: Confluence of Law and Religion?
Authors: Venter Francois
Published: August 2022

Why should we bear responsibility for the degradation of the environment? A wide range of responses is on offer to this question. Common to them all is they are all rooted in one or the other ontological and epistemic point of departure or set of premises. This raises the question of the relationship between law and religion and linkages of religion with environmental concerns. What emerges, perhaps against the volition of the scientific world, is that the foundational links between environmental law and religion are significant – even where environmentalists shirk from or even denounce religion. Justification of this view is found in concise survey of the essence of law and religion. The analysis leads to the notion of stewardship, a concept steeped in, but not exclusive to religion in its diverse manifestations. Examples of ecocentric religious attitudes – ranging from the traditions of the North American Anishinabek, aboriginal Australians and indigenous African culture to Buddhism and Hinduism, Judaism and Christianity in its principal manifestations – provide a broad picture of adherence to beliefs in human responsibility to take care of the environment. This widespread conviction of stewardship endures despite awareness of the human inability to create or sovereignly determine the course of nature (here termed "the hypothesis of incompetence").
Not white enough, not black enough
Authors: Thomas Cornelius
Published: August 2022

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Inteligencia emocional de mujeres y varones universitarios de la ciudad de Juliaca
Authors: Gutiérrez Echegaray Carliño Engut
Published: August 2022

Objetivo: Determinar la diferencia de los niveles de la Inteligencia Emocional entre mujeres y varonesuniversitarios de la ciudad de Juliaca, 2021. Metodología: De enfoque cuantitativo de tipo descriptivocomparativo, de diseño no experimental, de corte transversal. Por otro lado, la población de estudioestuvo comprendida por 208 personas; 113 mujeres y 95 varones; que se encuentren cursando laeducación universitaria con edades comprendidas entre los 16 a 18 años de edad, para la recolecciónde datos se utilizó el instrumento llamado “Inventario de Inteligencia Emocional de BarON- ICE, NA”forma completa; adaptado y estandarizado por Nelly Ugarriza en el Perú. Este instrumento costa de 5dimensiones los cuales son: Intrapersonal, Interpersonal, Adaptabilidad, Manejo del Estrés, Estado deÁnimo General. Resultados: Al concluir esta investigación se encontró en los resultados un valor deInteligencia emocional de (p=0,00) demostrando así que si existe diferencia en el nivel de inteligenciaemocional de mujeres y varones universitarios de Juliaca, a su vez cabe resaltar que el resultadoes más favorable al género femenino, paralelamente en las diferentes dimensiones que se evalúanconjuntamente; se obtuvieron resultados que nos dicen que en dimensiones como: Intrapersonal,Interpersonal y Manejo de Estrés, si existe diferencia entre mujeres y varones, a su vez en dimensionescomo: Adaptabilidad y Estado de ánimo en General, no existen diferencias significativas entre mujeresy varones universitarios de la ciudad de Juliaca.
Доказательства вреда: опыт пациентов и медицинские стандарты в судебных решениях
Authors: Бороздина Екатерина , Ельницкий Егор , Ходоренко Дарья
Published: August 2022

Основные тенденции современной системы здравоохранения – это стандартизация работы врачей, основанная на принципах доказательной медицины, и переход к пациентоориентированной медицинской помощи. Связь этих тенденций остается предметом дебата в социологии медицины. Часть авторов рассматривает пациентоориентированную медицинскую помощь как составляющую доказательной медицины и связанных с ней стандартов, другие утверждают, что эти принципы противоречат друг другу, а повсеместное внедрение доказательности мешает медицинским специалистам учитывать особенности опыта конкретных пациентов. Мы изучили, какую рамку для соотношения пациентоориентированности и стандартизации задает судебная практика: как особенности опыта пациента и следование парадигме доказательной медицины интерпретируются в рамках судебных разбирательств, какие прагматические последствия имеют данные интерпретации. Мы рассмотрели нормативные представления о медицинской практике и позиции пациента в системе здравоохранения, которые можно вычленить из текстов судебных решений. Мы обращаемся к судебным решениям как к документам, отражающимсовременные принципы контроля над работой медиков и имеющим практические последствия для социальных отношений в здравоохранении. В рамках исследования создана уникальная репрезентативная база данных из текстов 498 судебных решений первой инстанции по гражданским искам пациентов к медицинским организациям за 2018 г. Исследование выполнено в стратегии смешивания методов (mixed methods). Для изучения того, как стандарты доказательной медицины и внимание к опыту пациентов интерпретируются и задействуются в судебных решениях, мы осуществили анализ текстов 52 случайно отобранных документов. С помощью регрессионного анализа данных 498 решений выяснено, какие практические последствия имеют представленные в тексте интерпретации. Показаны статистически значимые связи между переменными, квантифицирующими обстоятельства конфликта между медицинскими профессионалами и пациентами, запрошенными стороной истцов суммами и решением суда о размере компенсации. С помощью качественного анализа текстов судебных решений описано, как в документах интерпретируется (не)следование медицинским стандартам и доказывается значимость вреда, причиненного потерпевшим.
Территориальная доступность высокотехнологичной онкологической помощи в СЗФО
Authors: Булина Анна , Раскина Юлия , Комаров Юрий , Барчук Антон
Published: August 2022

Территориальная доступность онкологической высокотехнологичной медицинской помощи (OВМП) играет важную роль в успехе лечения рака. Близость к медицинскому учреждению, где пациент может получить необходимую ему помощь, способствует лучшему исходу лечения – пациенту проще узнать, что те или иные виды медицинской помощи могут быть ему предложены, легче организовать посещение медицинского учреждения и согласовать необходимые для лечения мероприятия, пациент и сопровождающие его лица не несут дополнительной финансовой нагрузки на покупку билетов и размещение в месте прохождения лечения. Комиссия по онкологии журнала Lancet называет ситуацию с централизацией онкологической помощи в России уникальной и указывает территориальное неравенство в качестве одной из основных проблем на пути к эффективному контролю рака в нашей стране. В данной работе мы анализируем неравенство в потенциальной территориальной доступности для жителей Северо-­Западного федерального округа (СЗФО) медицинских учреждений, оказывающих ОВМП, предоставляемую гражданам РФ согласно Программе государственных гарантий бесплатного оказания гражданам медицинской помощи. Территориальная доступность измерена как время в пути пешком или с использованием автомобиля по дорожной сети от центра муниципальных образований до ближайшего медицинского центра, предлагающего OВМП. Мы рассчитываем ряд показателей неравенства для входящих в СЗФО регионов и в СЗФО в целом и оцениваем доли населения, имеющие разные уровни территориальной доступности. Большинство центров ОВМП сконцентрировано на юго-востоке СЗФО. Территориальная доступность для жителей Ненецкого автономного округа, Республики Коми и Республики Карелия, большой части территории Вологодской и Архангельской областей невысока. Неравенства в территориальной доступности существуют не только на уровне СЗФО в целом, но и внутри регионов округа. Наибольшие показатели внутрирегионального неравенства в территориальной доступности наблюдаются в Ленинградской, Псковской и Архангельской областях. Тем не менее пространственное неравенство территориальной доступности ОВМП в большей степени формируется за счет различий в доступности между регионами, чем за счет различий в доступности между муниципалитетами внутри регионов.
«Доверяй, но проверяй»: практики заботы о здоровье в условиях цифровизации здравоохранения
Authors: Богомягкова Елена
Published: August 2022

В статье представлены результаты эмпирического исследования интеграции цифровых технологий в практики заботы о здоровье жителей крупных городов России. Сегодня тренд цифровизации здравоохранения набирает обороты, проявляясь в организационных трансформациях медицинской сферы и воздействуя на повседневность современного человека. Являясь одним из аспектов перехода к медицине‑4П, цифровое здравоохранение опирается на идею пациента нового типа – ответственного, компетентного, готового самостоятельно принимать решения в отношении собственного благополучия, что должно привести к изменениям и в медицинской коммуникации. Изначально инновации рассматривались как проводники, способные обеспечить более эффективные и доверительные отношения врача и пациента. Однако до сих пор связь между (не)доверием медицинским профессионалам и вовлеченностью в опосредованные технологиями способы заботы о здоровье нечасто выступала предметом исследовательского интереса. В статье исследуется, что происходит с (не)доверием врачу в условиях цифровизации здравоохранения. В результате анализа 90 интервью получены данные об основных способах интеграции инноваций в практики поддержания хорошего самочувствия. Сегодня опыт пациента реализуется в режиме гибридной реальности, представляя собой комбинацию личных ощущений (физиологических, психологических), данных, поставляемых девайсами (выраженных в виде цифр, графиков и диаграмм), информации, получаемой из интернет-­источников и рекомендаций медицинских профессионалов. Место традиционного взаимодействия в паре «врач-пациент» занимает сеть реальных и виртуальных акторов, среди которых блогеры, родственники и знакомые, гаджеты, мобильные приложения, члены сетевых онлайн-­сообществ, чей статус определяется не дистанцией, а доверием, которое сегодня все больше диверсифицируется. Врач выступает лишь одним из звеньев такой сети. Несмотря на обилие источников медицинской информации и помощи, пациент полностью не доверяет никому, кроме самого себя, выступая точкой сборки сети, а доступ к многочисленным ресурсам запускает непрерывный поиск и (пере)проверку релевантной информации, что вносит значительную неопределенность в его опыт.
Выйти из тени: практики преодоления социальной эксклюзии больными эпилепсией
Authors: Касаткина Наталья , Шумкова Наталья , Токарева Наталья
Published: August 2022

Люди с эпилепсией часто становятся заложниками стигмы, опосредующей барьеры доступа к основным механизмам социальной интеграции и провоцирующей сокрытие болезни, самостигматизацию и развитие тревожных и депрессивных расстройств. В сложной ситуации самоопределения оказываются больные с легкой формой заболевания. Особенности переживания и преодоления ими опыта эксклюзии заслуживают особого внимания, поскольку раскрывают факторы успешной социальной интеграции. Статья посвящена изучению условий и причин социальной эксклюзии людей с эпилепсией, а также ресурсов и факторов ее преодоления. Эмпирической базой исследования являются данные десяти биографических интервью с больными эпилепсией, проведенных в 2021 г. Согласно анализу, значительное влияние на жизненную биографию людей с эпилепсией оказывают предрассудки, негативные социальные установки и стереотипы. Наиболее укорененными являются представления, о том, что эпилепсия – это психическое заболевание, несет риск смерти и передается по наследству. Искаженное восприятие становится следствием недостаточных знаний о сути заболевания не только у окружающих и самих больных, но и людей, имеющих медицинское образование. Стереотипы и ярлыки в отношении людей, страдающих эпилепсией, создают ограничения для их самореализации во всех сферах, определяющих социальную мобильность и благополучие. Наиболее выраженная эксклюзия наблюдается в сфере труда. Шансы на трудоустройство во многом зависят от наличия неформальных связей и правил, когда социальные взаимодействия по поводу устройства на работу осуществляются между знакомыми людьми и имеют персонализированный характер. При этом занятость людей с эпилепсией часто имеет прекарные черты. Социальной адаптации людей с эпилепсией способствуют внутренние факторы самоопределения. Внешние факторы, такие как общественная стигма, барьеры на рынке труда, оказываются преодолимыми при условии активизации личностных ресурсов. Достижительная мотивация, вера в собственную эффективность и высокий уровень притязаний стимулируют накопление культурного и социального капиталов как ресурса социальной инклюзии. Выход из тени эпилепсии обеспечивается благодаря деятельностно-­активистскому ресурсу самого больного и поддержке ближнего окружения.
Emotional Management of Healthcare Professionals in Palliative Care Settings
Authors: Угарова Анастасия
Published: August 2022

Palliative care has developed in Russia since the 1990s as an adopted Western institutional form within the ideological framework of a 'good death,' which suggests a holistic approach to patient suffering. The development of palliative care was not linear and has received systematic governmental support only over the last ten years. Psychological care and quality of life were only legally included in palliative care in 2019. As a consequence of the existing structural constraints in most organizations, all of the emotional labour is done by medical professionals often lacking training in the management of emotions. In this case, a key role is played by the leaders of the organization. The main objective of this work is to demonstrate how the management of emotions at the level of personal interactions is connected with the management of emotions at the organizational level. Emotion management in palliative care settings is analysed based on empirical evidence collected during the periods 2018–2019 and 2020–2021. During the research thirty-four interviews with specialists in the field of palliative care were collected. Materials are analysed through dramatic and cultural theories of emotions and theories of rituals. Key emotion management mechanisms in palliative care settings at the organizational level include team building and coordination; maintenance of collective emotions and collective solidarity; and the management of the space of the organization. At the individual level, emotional labour is carried out in accordance with the ideological framework of a 'good death.' Emotional labour is most often done through deep performance and is aimed at overcoming negative emotions such as anger, fear, or disgust. Management of emotions at the organizational level allows, first, to overcome the existing structural limitations; second, to adjust the volume and content of the emotional labour of employees.
Care for the Dying in the Late USSR (1970–80s)
Authors: Мохов Сергей
Published: August 2022

Disclosure of the diagnosis is a structural element of modern hospice ideology: the patient must be aware of the diagnosis in order to manage their dying and allow care instead of treatment. Care in hospices makes the last period of one’s life comfortable and maintains the habitual way of life of the dying person. Disclosure of diagnosis, awareness of death, and normalization of dying are thus three interrelated elements of modern hospice infrastructure. However, the case of the late USSR does not completely fit into this rule. On the one hand, there were no hospices in the Soviet Union because any formal disclosure of a diagnosis was banned. On the other hand, based on the study of archival and personal sources, I conclude that despite the concealment of the diagnosis, almost all dying people were aware of their impending death; in the absence of hospices, the dying received homecare; the patients also continued to lead their usual way of life. Hence, concealment of the diagnosis did not lead to unawareness of impending death and a lack of care infrastructure. To explain this paradox, I apply theoretical frameworks developed by Oleg Kharkhordin and Alexei Yurchak who argue that Soviet society had a binary structure consisting of a public ritual part and a private natural life. The nondisclosure of the diagnosis in the USSR was of a ritual form with a reversible function – hiding the diagnosis meant indeed disclosing it. This explains the structure of the Soviet model of care for the dying. The state did not officially deal with the dying and discharged them to their homes, providing them with some support. When the Soviet health care system sent a person home to die, it essentially segregated the private and the public, making it possible for care and dying to happen at home.
В эпицентре пандемии, на периферии социальной политики
Authors: Бурдяк Александра
Published: August 2022

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Stress eco 2030
Authors: Eugenio Eugrnio
Published: August 2022

L’ecostress si basa sulle alterazioni della cinetica regionale ed è oggi in una posizione centrale nella pratica cardiologica, con una indicazione di classe 1 per la diagnosi di coronaropatia nelle linee guida europee e americane. I test funzionali dovrebbero però esplorare anche altri aspetti della vulnerabilità fisiopatologica e prognostica del paziente, non solo la stenosi coronarica e l’ischemia inducibile. Nel protocollo stato dell’arte, lo stress eco valuta 5 diversi bersagli fisiopatologici che convergono concettualmente e logisticamente nel protocollo ABCDE. Lo step A valuta la cinetica regionale con eco bidimensionale. Lo step B valuta la congestione polmonare con le linee B all’eco polmonare. Lo step C valuta la riserva contrattile con la volumetria del ventricolo sinistro. Lo step D valuta il microcircolo coronarico con il Doppler pulsato nella coronaria discendente anteriore medio-distale. Lo step E valuta la risposta in frequenza mediante ECG. Sono finestre diagnostiche su 5 diverse riserve funzionali in un solo test: coronarica epicardica (A), diastolica (B), contrattile (C), coronarica microcircolatoria (D) e simpatica (E). Lo stress eco con protocollo ABCDE è ecumenico (adatto a tutti gli stress) e onnivoro (adatto a tutti i pazienti). L’ecocardiografia è ubiquitaria e democratica (disponibile ovunque e a chiunque), e si basa su una tecnologia sostenibile, perché a basso costo, senza radiazioni ionizzanti, e con minimo impatto ambientale.
Spasm, inflammation, coronary microcirculation and metabolism: how big is the iceberg under the stenosis
Authors: Morrone Doralisa
Published: August 2022

Ischemic heart disease (IHD) is a leading global cause of death and coronary artery disease has long been considered the main determinant of inducible ischemia and symptoms. However, after the performance of hundreds of thousands of percutaneous coronary revascularizations (PCI) worldwide, outcome analysis suggests that the direct relationship between chronic obstructive coronary atherosclerosis and ischemic heart disease (IHD) may represent a too simplified view of IHD; growing evidence has demonstrated the importance of a number of other underlying mechanisms. The purpose of this review is to highlight the multiple mechanisms responsible of myocardial ischemia.
Dieta, Cuore e Cancro: tra mito e realtà
Authors: D’Ambrosio Cristiana
Published: August 2022

Sebbene comunemente considerate come due entità patologiche separate, le malattie cardiovascolari e il cancro, le principali cause di morte, possiedono varie possibili interazioni, tra cui una serie di fattori di rischio simili (ad es. obesità, diabete, infiammazione cronica). Ogni cardiologo dovrebbe fornire consulenza per un corretto stile di vita (alimentazione, esercizio fisico, evitare il fumo e l’abuso di alcol); così facendo si potrebbero prevenire non solo le malattie cardiovascolari, ma anche il cancro. Inoltre, l’intervento su dieta, attività fisica e fumo si è dimostrato efficace anche in pazienti con tumori noti. Il ruolo di una dieta sana nella prevenzione del cancro è ben riconosciuto. Dati recenti indicano che seguire gli stessi consigli può anche migliorare la qualità della vita dei sopravvissuti al cancro. I pazienti con cancro al seno (BC) sono comunemente preoccupati per la dieta e l’alimentazione e spesso esprimono la necessità di ottenere informazioni relative alla salute e la volontà di cambiare dieta e stile di vita. Pertanto, essere consapevoli dei cambiamenti nella dieta dei sopravvissuti e delle esigenze di informazioni è fondamentale per gli operatori sanitari per guidarli verso scelte di vita ottimali.
Attività fisica e cancro: dalla prevenzione all’esercizioterapia
Authors: Lusardi Paola , Asteggiano Riccardo
Published: August 2022

Il ruolo dell’attività fisica nella prevenzione primaria delle neoplasie è noto; negli ultimi anni l’esercizio svolto con sistematicità ha acquisito un ruolo anche in prevenzione secondaria, riducendo il rischio di recidiva di cancro e migliorando la prognosi e la qualità di vita dei pazienti. L’esercizio fisico è altresì raccomandato per prevenire e contrastare la cardiotossicità dei trattamenti neoadiuvanti e adiuvanti, e per limitare gli effetti invalidanti di fatigue, sarcopenia e cachessia. Dalla letteratura internazionale e dalle esperienze di pratica clinica emerge sempre più l’importanza di introdurre programmi di esercizioterapia nella gestione globale del paziente oncologico, con una prescrizione sartoriale concordata a livello multidisciplinare (oncologo, cardiologo, fisiatra, fisioterapista), che tenga conto della storia naturale del tipo di cancro, del rischio di complicanze, degli effetti terapeutici e collaterali delle terapie in corso, oltre a valutare problemi di sicurezza ed eventuali controindicazioni.
Predicting The Discharge of Patients Via Machine Learning Based Discharge Predictive Model
Authors: Fauzia Salma , Anjum Romana
Published: August 2022

The primary objective of the work is to create a discharge roster for patients by employing various machine learning techniques and to predict the discharge of a patient. The performance of the proposed discharge predictive model is measured through various performance measures. The research work is carried out based on the dataset formed with actual data of patients in hospital. The machine learning (ML) based Discharge Predictive Model is developed by combining well known ML algorithms like K-Nearest Neighbour (KNN) algorithm, Random Forests algorithm and Light Gradient Boosting algorithm with optimum parameters, various feature combinations and pre-processing techniques. The performance of the proposed model is measured in terms of accuracy and it is compared with various existing techniques like SVM and NN. The result of the comparison study exhibit that the proposed predictive learning model attained enhanced accuracy than other ML techniques.
SCDC-Net: Skin Cancer Detection and Classification using Deep Q Neural Network with Hybrid Features
Authors: V Nyemeesha
Published: August 2022

Skin cancer is one of the most severe malignancies that may affect individuals of all ages. It can affect people of all races and ethnicities. Thus, early detection and treatment of skin cancer have the potential to save millions of lives. Because of the high degree of similarity between skin lesions, conventional machine learning approaches failed to provide the highest possible detection and classification accuracy in the skin cancer detection and classification (SCDC) system. To achieve the robust performance, this work is presented a SCDC-Net by employing deep learning, transfer learning models with hybrid features. Initially, UG-Net based transfer learning model is developed by combining generative adversarial networks (GAN) and U-Net. Here, UG-Net is used to remove hair from skin lesions and also preprocess enhances lesion. In addition, Hybrid U-Net (HU-Net) is used to localize the disease effected area of skin cancer. Further, various hybrid features are extracted from the segmented output by employing the gray-level cooccurrence matrix (GLCM) based texture characteristics, the discrete wavelet transform (DWT)-based low-level features, and the computation of image statistics for the texture, low-level, and colour features, respectively. In order to ensure the highest possible performance of the system, a deep q neural network (DQNN) was constructed for the classification of skin cancer using GLCM, DWT, and statistical colour features. The simulation results shows that the proposed method resulted in superior subjective and objective performance as compared to state of art approaches on ISIC-2019 public challenge dataset.
Deep Learning Based Fake News Detection
Authors: Urane Kimaya , Deshpande Arati
Published: August 2022

Social network connectivity is one of the most important countermeasures in today's world. we must use with caution or risk creating disaster problems and causing social upheaval. To address this problem, items and stories that spread quickly must be tracked for a set period of time. In this proposed method, we attempted to determine whether the news being disseminated around the world is genuine or not. Factors responsible for fake news detection are also discussed. So that disinformation can be controlled and has a direct impact on society's citizens. Analytical and advanced deep learning techniques are combined with natural language processing techniques. We gathered information from open sources, such as Kaggle. Following that, we used NLP techniques to preprocess and analyze the data. In the form of exploratory data analysis, there is a detailed representation of graphical plots (EDA). To gain a better understanding of the data through more precise statistics.
Chronicles of A.I. Pospelov Moscow Dermatovenerology and Cosmetology Society (MSDC was founded on October 4, 1891) Bulletin of the MSDC № 1146
Authors: Yakovlev Alexey B. , Maximov Ivan S.
Published: August 2022

On February 15, 2022, the 1146th meeting of the Moscow Society of Dermatovenereologists and Cosmetologists named after A.I. Pospelov took place.
The meeting was held in a remote format. There were 120 participants in total. Accepted as a member of MSDC 1 person.
Three clinical clinical observations are presented. The first of them is a case of giant-cell variant of annular granuloma with extensive skin lesions. Annular granuloma is a benign dermatosis of unclear etiology, prone to spontaneous resolution; it occurs as a reaction to ultraviolet radiation against the background of lymphoproliferative or autoimmune diseases, sarcoidosis, chronic lung diseases, prostate cancer. In the presented case, the clinical diagnosis was confirmed by histological examination.
The second presentation was devoted to livedoid vasculopathy with a tendency to thrombotic complications. This is a relatively rare disease that is excluded from the group of vasculitis due to one distinctive feature ― a pronounced tendency to thrombosis in the absence of indications of the primary nature of inflammation. In therapy, in addition to medications, the appointment of vitamins is mandatory.
The third observation concerned Merkels carcinoma, one of the relatively rare but extremely aggressive most malignant forms of skin cancer. With epithelial and neuroendocrine differentiation, which is superior to melanoma in terms of aggressiveness of the course and tendency to metastasis. Due to the rare occurrence of the tumor, diagnostic errors are frequent. Diagnosis requires histological and immunohistochemical examination. Any inflamed atheroma or synovial cyst that recurs after surgical treatment should be alarming.
Scientific reports were heard on the biological therapy of psoriasis, a chronic systemic immunoassociated disease of a multifactorial nature with a hereditary predisposition characterized by the formation of inflammatory papules and plaques, often with joint damage (arthropathy), accelerated proliferation of epidermocytes and a violation of their differentiation, an imbalance between pro-inflammatory and anti-inflammatory cytokines and chemokines. And the second scientific report contained information about modern approaches to the treatment of acantholytic pemphigus.
Clinical and pathogenetic justification of the use of methotrexate in the treatment of progressive non-segmental vitiligo
Authors: Tavitova Alana R. , Lomonosov Konstantin M.
Published: August 2022

BACKGROUND: Vitiligo is an urgent problem both for patients and for the scientific community of dermatologists. There are many studies aimed at finding new methods of therapy for this disease, but there are no effective schemes for repigmentation of foci and stabilization of the process in modern dermatology. In this regard, the search for means that have a pathogenetic effect is relevant.
AIMS: Clinical and laboratory evaluation of the effectiveness of methotrexate in vitiligo.
MATERIALS AND METHODS: Preliminary results of a study of the effectiveness of methotrexate in the treatment of vitiligo are presented. Clinical effects were assessed using the VES index (Vitiligo extent score). The dynamics of immunological parameters and the influence of vitiligo on the quality of life were also determined.
The study included 77 patients suffering from non-segmental vitiligo. All the subjects were divided into 2 groups. Patients of group 1 (39 patients) received methotrexate in combination with phototherapy, patients of group 2 (38 patients) underwent a course of UVB-311nm. The area of depigmentation was determined, and after treatment repigmentation, relative to the surface area of the body. The dynamics of the immune status against the background of therapy was analyzed. The correlation of the prevalence of the process with the quality of life was evaluated. The duration of the study was 4 months.
RESULTS: There were no statistically significant differences in clinical and laboratory parameters among the groups before treatment. Patients included in group 1 and receiving combination therapy with methotrexate and medium-wave narrow-band therapy with UVB-311nm demonstrated more active repigmentation of vitiligo foci than the studied 2 groups. Also, patients of this group demonstrated the most active positive dynamics of the dermatological quality of life index, correlating with the prevalence of the process. Analysis of the dynamics of immune status indicators allowed us to conclude that the best tendency to normalize cytokine levels among group 1 patients.
CONCLUSIONS: Our study demonstrated the clinical and pathogenetic efficacy of methotrexate. Small doses of the drug are well tolerated, which allows a long-term effect on pathogenetic mechanisms, stabilizing the skin process.
Folliculitis decalvans: clinical and morphological characteristics (literature review)
Authors: Smirnova Irina O. , Medetskaya Olga M. , Bessalova Anna Y. , Shin Natalia V.
Published: August 2022

Folliculitis decalvans is a rare disease of primary cicatricial alopecias, about 11% of all alopecias of this group. Dermatosis was first described by the French dermatologist Charles-Eugne Quinquaud in 1888 and 1889. In recent decades, the number of publications devoted to the etiopathogenesis, clinical and histological characteristics, as well as approaches to the treatment of folliculitis decalvans has increased.
The article presents the results of data analysis on the databases Scopus, Web of Science, MedLine, The Cochrane Library, EMBASE, Global Health, CyberLeninka, RSCI.
The etiopathogenesis of the disease is still unknown. The role of seborrhea and skin colonization by Staphylococcus aureus, as well as impaired local immune response and the presence of a genetic predisposition, have previously been discussed. Folliculitis decalvans is now thought to be a result of persistent disruption of the skin barrier that predisposes to subepidermal invasion by opportunistic microorganisms, including Staphylococcus aureus. Clinical, dermatoscopic (trichoscopic) and histological characteristics of dermatosis are being specified. Its characteristic clinical features are a persistent progressive course, the formation of alopecia foci with a rich red edge, pustules and crusts along the periphery of the alopecia foci, polytrichia and the formation of a dense scar that rises above the surrounding skin. Dermatoscopic characteristics depend on the intensity of the inflammatory process. Specific trichoscopic signs of the disease include follicular pustules, yellow tubular desquamation, yellow crusts, perifollicular erythema, perifollicular hemorrhages, and fine tortuous vessels. Depending on the number of these signs, the degree of inflammation is determined. Histological features of the disease include a massive perifollicular infiltrate, the formation of gaps between the epithelium of the follicles and the surrounding stroma, and in the final stages of the process ― fibrous tracts, diffuse fibrosis in the dermis.
The treatment of folliculitis decalvans are antibacterial drugs, it is also possible to treat with courses of topical corticosteroids, antiseptic solutions.
We assume that the systematization of information about the etiopathogenesis and approaches to the diagnosis and treatment of folliculitis decalvans will improve the diagnosis among other primary cicatricial alopecia and the choice of the tactics of treating folliculitis decalvans.
MicroRNA as a diagnostic marker in cutaneous T-cell lymphomas
Authors: Olisova Olga Yu. , Demkin Vladimir V. , Chernova Natalia G. , Amshinskaya Jessika R. , Kazakov Andrey  A.
Published: August 2022

BACKGROUND: In recent years, thanks to the development of methods of molecular genetic analysis, microRNA has become one of the promising markers for the diagnosis of many human diseases.
AIMS: to study microRNA as a new method for the diagnosis of fungal mycosis.
MATERIALS AND METHODS: The study included 30 patients with histologically confirmed diagnosis of T-cell lymphomas of the skin, 25 were diagnosed with fungal mycosis, 5 ― Cesari syndrome. The control group consisted of 10 patients with benign lymphoproliferative dermatoses. The patients underwent the determination of microRNA 223, 16, 326, 663, 423, 711 in blood plasma. MicroRNA was also detected in plasma in patients with T-cell lymphomas of the skin at early and late stages.
RESULTS: Statistically significant difference of 223, 16, 326, 711 microRNAs in blood plasma was revealed in patients with fungal mycosis, compared with patients with benign lymphoproliferative dermatoses. Statistically significant difference of 663 microRNA in blood plasma was revealed in patients with T-cell lymphomas of the skin at early and late stages. A statistically significant difference of 223, 711 microRNAs in blood plasma was revealed in patients with fungal mycosis at an early stage compared with patients with benign lymphoproliferative dermatoses.
CONCLUSION: The determination of microRNA 223, 16, 326, 711 in blood plasma can be used for early diagnosis of T-cell lymphomas of the skin.
Professional Identity in Guidance and Counseling: The Perspective of Prospective Counselors
Authors: Rahman Fathur , Nurmalasari Yuli , Aminah Siti , Taufiq Agus
Published: August 2022

Abstract: This study aims to describe prospective counselors’ perceptions of professional identity concepts in the guidance and counseling field. This study used a qualitative approach with an exploratory, descriptive design. Research data were collected through open questionnaires and focus group discussions. The data sources were fifteen guidance and counseling students from three different classes. Data analysis was carried out by searching for themes and determining the correlation between them to attain interpretation. The results of the study show that professional identity is conceptualized as a typical characteristic or a symbol of professional conduct in the profession of guidance and counseling. Meanwhile, the dimensions of professional identity according to students are categorized into professional competence, personality, personal appearance, knowledge of the profession, and professional ethos. Lastly, for the student, professional identity is something that moves dynamically.
Abstrak: Penelitian ini bertujuan untuk mendeskripsikan persepsi calon konselor terhadap konsep identitas profesional dalam bidang bimbingan dan konseling. Penelitian ini menggunakan pendekatan kualitatif dengan desain deskriptif eksploratif. Data penelitian dikumpulkan melalui kuesioner terbuka dan diskusi kelompok terfokus. Sumber datanya adalah lima belas mahasiswa bimbingan dan konseling dari angkatan yang berbeda. Analisis data dilakukan dengan cara mengidentifikasi topik dan menentukan keterkaitan untuk mencapai interpretasi. Hasil penelitian menunjukkan bahwa identitas profesional dikonseptualisasikan sebagai ciri khas atau simbol perilaku profesional dalam profesi bimbingan dan konseling. Sedangkan dimensi identitas profesional menurut mahasiswa dikategorikan terdiri dari kompetensi profesional, kepribadian, penampilan pribadi, pengetahuan profesi, dan etos kerja profesional. Selain itu, mahasiswa juga mempersepsikan identitas profesional bimbingan dan konseling merupakan sesuatu yang bergerak dinamis.
Effectiveness of Solution-Focused Brief Counseling and Motivational Interviewing in Improving Students’ Self-Disclosure
Authors: Indriani Iftitah , Wibowo Mungin Eddy , Mulawarman Mulawarman
Published: August 2022

Abstract: This study investigates the effectiveness of solution-focused brief counseling and motivational interviewing in enhancing students’ self-disclosure. This study used a randomized pretest-posttest control group design. The sixteen participants from State Junior High School 3 Comal, Indonesia, were selected through nonprobability sampling with purposive sampling. The participants were divided into experiment and control groups. For the research instruments, this study used The Self-Disclosure Questionnaire developed by Jourard to measure students’ self-disclosure. The obtained data were analyzed using the repeated measures ANOVA test. Our analysis results showed that solution-focused brief counseling and motivational interviewing were effective in improving students’ self-disclosure. Therefore, the school counselor can implement both solution-focused brief counseling and motivational interviewing to enhance their students’ internal potential and self-disclosure. Future studies are suggested to widen the research participants and analyze the effects of gender and age differences on the effectiveness of solution-focused brief counseling and motivational interviewing in improving students’ self-disclosure. Abstrak: Penelitian ini bertujuan untuk mengetahui keefektifan solution-focused brief counseling dan motivational interviewing untuk meningkatkan self-disclosure peserta didik. Penelitian ini menggunakan desain randomized pretest posttest control group design. Teknik pengambilan sampel menggunakan nonprobability sampling dengan sampling purposive. Sampel yang dilibatkan sebanyak enam belas peserta didik di Sekolah Menengah Pertama Negeri 3 Comal, Indonesia yang dibagi sama rata pada kelompok eksperimen dan kelompok kontrol. Instrumen yang digunakan untuk mengukur self-disclosure adalah The Self-Disclosure Questionnaire yang dikembangkan oleh Jourard. Metode analisis data menggunakan uji repeated measures ANOVA. Hasil menunjukkan bahwa solution-focused brief counseling dan motivational interviewing efektif untuk meningkatkan self-disclosure peserta didik. Berdasarkan penelitian, konselor sekolah dapat mengaplikasikan solution-focused brief counseling dan motivational interviewing untuk meningkatkan potensi internal dan self-disclosure peserta didik. Peneliti selanjutnya dapat memperluas cakupan subjek penelitian, menganalisis perbedaan gender dan usia antar subjek penelitian dalam keefektifan pendekatan solution-focused brief counseling dan motivational interviewing untuk meningkatkan self-disclosure peserta didik.
El marco normativo aplicable a las plataformas de financiación colectiva. Comparativa entre la Unión Europea, España y Latinoamérica
Authors: Ramírez-Herrera Luis Miguel
Published: August 2022

This paper analyzes and compares the regulatory framework applicable to existing crowdfunding platforms in the European Union, Spain and Latin America, with a focus on the countries of Mexico, Brazil, Argentina, Colombia and Peru. The existence of a great heterogeneity in the degree of development of the regulatory framework and in the content of the regulations between the European Union and Latin America is concluded, which highlights the need for a harmonization of international regulatory frameworks in order to favor the expansion of this type of industry and the security of international investors.
DRESS syndrome by sulfonamides, about a case
Authors: Contreras Diego Mendoza , Torres José Maria Zepeda , Gutiérrez Grecia Jazmín García , Gutiérrez Félix Osuna , Soberanes Larissa Michelle Navarro
Published: August 2022

Among the most feared toxico-dermas is drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, a rare drug dermatitis that occurs after acute exposure to drugs whose clinical impact is based on multiple organs (skin, liver, kidneys, lungs, heart) and cell lines (eosinophils and lymphocytes). It is an entity with high mortality if it is not identified early, its treatment consists of the immediate suspension of the responsible drug and the administration of steroids, these being the therapeutic protagonists. A 64-year-old male patient with clinical, biochemical and histopathological criteria compatible with DRESS syndrome. It is essential to suspect the clinical course of DRESS syndrome before the appearance of dermatosis with multisystem involvement associated with the use of drugs, emphasis is placed on its early identification and the establishment of timely treatment to modify its prognosis.
Topical clobetasol propionate 0.025%: a therapeutic dermatologic asset
Authors: Singhal Deepak , Deivasigamani Revathi , Bhavsar Bhavik A. , Ganisetti Lakshmi Sitara , Menghani Purshotam R. , Majid Imran , Kukkadapu Naveen Kumar , Srinivasulu Gillella , Amol Sneha , Shah Rani Sudhir , Wani Mashkoor Ahmed
Published: August 2022

Over several decades, topical corticosteroids (TCs) have been used in the treatment of various dermatoses such as psoriasis, contact dermatitis, and eczema, among others. The TCs act by reducing inflammation and irritation after topical application. The therapeutic effect of TCs is bestowed through their diverse biologic properties such as anti-inflammatory, antiproliferative, vasoconstrictive, and antimitotic activity, and its role in the reduction of lymphocyte reactivity, modulation of Langerhans cell expression, cellular and lysosomal membrane stabilization, reduction of recruitment of neutrophils and monocytes, reduction of mast cell density and reactivity, and sensitization of immunoglobulin E. Clobetasol propionate (CP) 0.025% is a class I TC available as a cream formulation. The cream formulation contains half the concentration of conventional CP (0.025%), without the loss of therapeutic potency. The lack of additives such as penetration enhancers (propylene glycol) further prevents cutaneous microbiome alteration. This comprehensive case series covers the potent efficacy and safety of ImpoyzTM (CP) Cream 0.025% in the management of various dermatological disorders.
Food Polymeric Packaging Life Cycle Assessment (LCA)
Authors: Sadeghizadeh-Yazdi Jalal
Published: August 2022

The Article Abstract is not available.
The Effects of Nigella Sativa Oil on Serum Levels Inflammatory Markers, Oxidative Stress Markers, and Lipid Profile in Dialysis Patients: A Double-Blind Clinical Trail
Authors: Kooshki Akram , Taghizadeh Mohsen , Akbarzadeh Roya
Published: August 2022

Background: High concentrations of serum inflammatory and oxidative stress markers and lipid abnormities are important risk factors for cardiovascular diseases in hemodialysis patients. This study aims to investigate the effects of Nigella sativa oil on serum levels inflammation and oxidative stress markers and lipid profile in hemodialysis patients.
Methods: Fifty hemodialysis patients participated in this randomized, double-blind, placebo-controlled clinical trial. The patients were randomly assigned into two groups, including receiving 2 tablets of Nigella sativa oil (1000 mg/day, NG) and receiving placebo (PG), for 8 weeks. Blood samples were taken from the patients at the beginning and the end of the study after 12 to 14 hour fasting for measuring serum markers. Then, levels of triglycerides (TG), total cholesterol (TC), LDL-c, HDL-c, high sensitivity C-reactive protein (hs-CRP), and malondialdehyde (MDA) were measured.
Results: Consumption of Nigella sativa oil as a supplement decreased levels of TC (P = 0.0002), LDL-c (P = 0.001), mean serum hs-CRP, and MDA compared to the PG (P = 0.001).
Conclusion: The Nigella sativa oil supplement may reduce serum hs-CRP and MDA, TC, LDL-c, and risk factors for cardiovascular diseases in hemodialysis patients.
Behavioral Determinants of Obesity among Adolescents: A Qualitative Study
Authors: Chaleshgar- Kordasiabi Mosharafeh , Ramezani Atena , Naghibi Seyed Abolhasan , Yazdani Cherati Jamshid , Khazai-Pool Maryam , Abbasi-Shavazi Masoumeh
Published: August 2022

Background: Overweight and obesity are the most serious public health challenges of developed and developing countries. The prevalence of childhood obesity has increased worldwide. This study aims to identify the behavioral determinants of overweight and obesity among adolescents.
Methods: This is a qualitative study with directed approach to content analysis of in-depth semi-structured interviews. A total of 27 obese and overweight students (11girls, 16 boys) were recruited in this study based on the PRECEDE model (predisposing factor). The participants were recruited using a purposive sampling method to reach the maximum variation sampling. This sampling took over 6 months in 2018 at the Ghaemshahr middle school. Content analysis approach (directed) was used to analyze the interview.
Results: Five main themes and 20 sub-themes of behavioral determinant were emerged from the interview. The main themes included perceived benefit, perceived threaten, self-efficacy, cues to action, and locus of control. The subthemes included self-empowerment, motivation and diligence role, enough information and parent pressure, long term benefits, physical health, doing favorite sports, perceived susceptibility and perceived severity, and internal and external locus of control.
Conclusion: Self-efficacy and perceived benefit are the most significant determinants of preventive behavior in obese and overweight students; therefore, considering  these variables in students can be applied in designing an interventional program that affect obesity preventive behaviors, increase parents’ awareness and school authorities.