bluuebunny/crossref_metadata_2025 huggingface dataset:
Network pharmacological analysis for the identification of the molecular mechanism ofLilium brownii(Baihe) against gastric cancer: 3-Demethylcolchicine targeting androgen receptor
Authors: An Zi-Yi , Zhang Wen-Hao , Hu Xiao-Gang , Yuan Le-Qi , Jin Wei-Lin
Published: April 2023

Lilium brownii(Baihe) contains several bioactive compounds with anti-cancer properties. This study aimed to predict the anticancer targets and related pathways of Baihe for the treatment of gastric cancer (GC) by using network pharmacology and to further explore its potential mechanism in GC. The active compounds and their target proteins were screened from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). The OMIM, CTD, and GeneCards databases provided information on GC-related targets. After the overlap, the targets of Baihe against GC were collected. The STRING network platform and Cytoscape software were used for protein–protein interaction (PPI) network and core target investigations. Network pharmacology predicted that the principal targets were retrieved from the Starbase database in connection with the GC overall survival. Molecular docking was also used to validate Baihe and the targets’ high affinity. Finally, the DAVID online tool was used for the overlapping target Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. The TCMSP database showed that Baihe has seven bioactive components. Apoptosis and p53 signaling pathways were primarily enriched in overlapping genes according to KEGG analysis. Androgen receptor (AR) was identified as a major target by combining the PPI network, KEEG enrichment, and target gene prognostic analysis. Molecular docking results verified that the Baihe’s 3-demethylcolchicine has a high affinity for the GC target AR. Based on the results of network pharmacology analysis based on data mining and molecular docking methods, the multi-target drug Baihe may be a promising therapeutic candidate for GC, but further in vivo/ex vivo research is required.

Graphical Abstract
A PCR-RFLP method for the detection of CRISPR-induced indels
Authors: Angelopoulou Lydia , Stylianopoulou Electra , Tegopoulos Konstantinos , Farmakioti Ioanna , Grigoriou Maria E. , Skavdis George
Published: April 2023

CRISPR-based technologies have revolutionised genome editing and are widely used for knocking out genes in cell lines and organisms. From a practical perspective, a critical factor that largely influences the successful outcome of CRISPR gene knockout experiments is the reliable and fast identification of fully mutated cells carrying exclusively null alleles of the target gene. Here we describe a novel strategy based on the well-documented reliability and simplicity of the classical PCR-Restriction Fragment Length Polymorphism (RFLP), which allows the assessment of the editing efficiency in pools of edited cells and the effective identification of cell clones that carry exclusively mutated alleles. This fast and cost-effective method, named PIM-RFLP (PCR Induced Mutagenesis-RFLP), is executed in two steps. In the first step, the editing target is amplified by a set of mutagenic primers that create a restriction enzyme degenerate cleavage site in the amplification product of the wild type allele. As a proof of principle, we chose the XcmI restriction site because it is especially suitable since it has the particularity of containing nine centrally placed non-specific nucleotides. This gives great flexibility in the mutagenic primers design and allows for efficient execution of the mutagenic PCR. In the second step, the evaluation of the editing efficiency in pools of edited cells or the identification of fully mutated single-cell derived clones is achieved following the standard procedure for any PCR-RFLP assay: digestion of the PCR products and analysis of the restriction fragments in an agarose gel.

GRAPHICAL ABSTRACT
Dynamic oxygen-enhanced MRI of the lung at 3 T: feasibility, repeatability and reproducibility
Authors: Kim Mina , Naish Josephine H. , Needleman Sarah H. , Tibiletti Marta , Taylor Yohn , O’Connor James P. B. , Parker Geoff J. M.
Published: April 2023

Purpose

Dynamic T1-weighted lung oxygen enhanced MRI (OE-MRI) is challenging at 3 T due to decreased longitudinal relaxivity of oxygen and increased magnetic susceptibility difference between air and tissue interfaces relative to 1.5 T, leading to poor signal quality. In this work, we evaluate the robustness of an alternative T2*-sensitised lung dynamic OE-MRI protocol in humans at 3 T.

Methods

Simulations were performed to predict OE contrast behaviour and optimise the MRI protocol. Sixteen healthy subjects underwent dynamic free-breathing OE-MRI acquisitions using a dual echo RF-spoiled gradient echo acquisition at 3 T on two MRI scanners at different institutions. Non-linear registration and tissue density variation correction were applied. Percent signal enhancement (PSE) maps and ΔR2* were derived. Intra-class correlation coefficient (ICC) and Bland-Altman analyses were used to evaluate reproducibility of the OE indices across two sites and vendors as well as scan-rescan repeatability.

Results

Simulations and experimental data show negative contrast on oxygen inhalation due to substantial dominance of ΔR2* at TE longer than 0.2 ms when using our chosen flip angle and TR. Mean PSE values were TE dependent and mean ΔR2* was 0.14 ms-1± 0.03 ms-1, ICC values for intra-scanner (ICCintra) and inter-scanner (ICCinter) variability for OE indices were high (ICCintra> 0.74; ICCinter= 0.70) and 95% limits of agreement showed strong agreement of repeated measures.

Conclusion

Our results demonstrate excellent scan-rescan repeatability for the PSE indices and good reproducibility for ΔR2* across two sites and vendors, suggesting potential utility in multi-centre clinical studies.
mps1andmadmutations reduceCryptococcus neoformanstitan cell viability
Authors: Aktar Koly , Davies Thomas , Leontiou Ioanna , Clark Ivan , Spanos Christos , Wallace Edward , Tuck Laura , Arockia Jeyaprakash A. , Hardwick Kevin G.
Published: April 2023

Cryptococcus neoformansis an opportunistic, human fungal pathogen which undergoes fascinating switches in cell cycle control and ploidy when it encounters stressful environments such as the human lung. Here we carry out a mechanistic analysis of the spindle assembly checkpoint (SAC) which regulates the metaphase to anaphase transition, focusing on Mps1 kinase and the downstream checkpoint components Mad1 and Mad2. We demonstrate thatCryptococcus mad1Δormad2Δstrains are unable to respond to microtubule perturbations, continuing to re-bud and divide, and die rapidly as a consequence. Fluorescent tagging of Chromosome 3, using a lacO array and mNeonGreen-lacI fusion protein, demonstrates thatmadmutants are unable to maintain sister-chromatid cohesion in the absence of microtubule polymers. Thus, the classic checkpoint functions of the SAC are conserved inCryptococcus. In interphase, GFP-Mad1 is enriched at the nuclear periphery, and it is recruited to unattached kinetochores in mitosis. Purification of GFP-Mad1 followed by mass spectrometric analysis of associated proteins show that that it forms a complex with Mad2 and that it interacts with other checkpoint signalling components (Bub1) and effectors (Cdc20 and APC/C sub-units) in mitosis. We also demonstrate that overexpression of Mps1 kinase is sufficient to arrestCryptococcuscells in mitosis, and show that this arrest is dependent on both Mad1 and Mad2. We find that a C-terminal fragment of Mad1 is an effectivein vitrosubstrate for Mps1 kinase and map several Mad1 phosphorylation sites. Some sites are highly conserved within the C-terminal Mad1 structure and we demonstrate that mutation of threonine 667 (T667A) leads to loss of checkpoint signalling and abrogation of theGAL-MPS1arrest. Thus Mps1-dependent phosphorylation of C-terminal Mad1 residues is a critical step inCryptococcusspindle checkpoint signalling. Finally, we analyse the phenotype ofmadandmps1mutants during titan cell generation: quantitating viability of titan cells and their daughters generated during the ensuing reductive division. Themad1Δ, mad2ΔandmpsΔmutants show significantly reduced viability: many titans are dead and others produce slow growing colonies. We propose that theseCryptococcus neoformanscheckpoint proteins have important roles in ensuring high fidelity chromosome segregation during stressful conditions, such that those heightened during its polyploid infection cycle.
Global Profiling of Differentiating Macrophages Identifies Novel Functional Long Non-coding RNAs Regulating Polarization and Innate Immune Responses
Authors: Valverde Araceli M. , Naqvi Raza A. , Naqvi Afsar R.
Published: April 2023

Macrophages (Mφ) are functionally dynamic immune cells that bridge innate and adaptive immune responses. However, the underlying epigenetic mechanisms that control the macrophage plasticity and innate immune functions are not well-elucidated. Here we performed transcriptome profiling of differentiating M1Mφ and M2Mφ and identified thousands of previously known and novel lncRNAs. We characterized three Mφ-enriched lncRNAs (LRRC75A-As1, GAPLINC and AL139099.5) with novel functions in Mφ differentiation, polarization and innate immunity. Knockdown of LRRC75A-As1, and GAPLINC downregulated Mφ differentiation markers CDw93 and CD68, and skewed macrophage polarization by decreasing M1 markers but had no significant impact on M2 markers. LRRC75A-As1, and GAPLINC RNAi in Mφ attenuated bacterial phagocytosis, antigen processing and inflammatory cytokine secretion supporting their functional role in potentiating innate immune functions. Mechanistically, lncRNA knockdown perturbed the expression of multiple cytoskeleton signaling thereby impairing Mφ migration suggesting their critical role in regulating macrophage polarity and motility. Together, our results show that Mφ acquire a unique repertoire of lncRNAs to shape differentiation, polarization and innate immune functions.
Simultaneous representation of multiple time horizons by entorhinal grid cells and CA1 place cells
Authors: Chaudhuri-Vayalambrone Prannoy , Rule Michael , Bauza Marius , Krstulovic Marino , Kerekes Pauline , Burton Stephen , O’Leary Timothy , Krupic Julija
Published: April 2023

Grid cells and place cells constitute the basic building blocks of the medial entorhinal-hippocampal spatial cognitive map by representing the spatiotemporal continuum of an animal’s past, present and future locations. However, the spatiotemporal relationship between these different cell types is unclear. Here we co-recorded grid and place cells in freely foraging rats. We show that average time shifts in grid cells tend to be prospective and are proportional to their spatial scale, providing a nearly instantaneous readout of a spectrum of progressively increasing time horizons ranging hundreds of milliseconds. Average time shifts of place cells are generally larger compared to grid cells and also increase with place field sizes. Moreover, time shifts displayed nonlinear modulation by the animal’s trajectories in relation to the local boundaries and locomotion cues. Finally, long and short time shifts occurred at different parts of the theta cycle, which may facilitate their readout. Together, these findings suggest that progressively increasing time horizons of grid and place cells may provide a basis for calculating animal trajectories essential for goal-directed navigation and planning.
Tension between the safe flow of government data across organizational boundaries and fragmentations in secure collaboration: the Chinese e-government
Authors: Mao Zijun , Zhu Yuqian
Published: April 2023

Purpose

The study focuses on influential factors of collaboration on government data security by the Chinese government.

Design/methodology/approach

The article explores the case of e-government in the Chinese centralized unitary state system context, using a structured–pragmatic–situational (SPS) approach and the boundary theory as an analytical lens.

Findings

The findings indicate that e-government operates in highly interconnected environments where the safe flow of government data requires collaborative and cross-boundary strategies. Any organization is a potential “weakest link”. In addition, collaboration is fragmented by ambiguous accountability and organizational inertia across government departments, resources differences and limited visibility and measurability of security efforts across government levels and conflicts and uncertainties in principal–agent relationships. The solutions for those obstacles are also discussed from the multi-function, multi-level and multi-actor dimensions, respectively. A multi-dimensional overarching security model for the flow of government data is proposed.

Originality/value

The study advances the technology-oriented micro-analysis of previous studies on government data security to cross-organizational revealing at the macrolevel by connecting streams of research in information systems and public administration. These findings will contribute to making the safe flow of government data more resilient in the transformation of e-government.
Managing effective labor market entry: proactive coping and self-employment intention among Polish small business owners
Authors: Ślebarska Katarzyna , Stremska Aneta , Kowalski Grzegorz
Published: April 2023

Purpose

Self-employment is considered one of the responses to precarious employment, particularly among those who lost jobs during an economic crisis. Although starting a new business is widely available, operating new ventures remains challenging. This article aims to explore the premises of self-employment success, namely self-employment intention and proactive coping as crucial predictors of further performance.

Design/methodology/approach

The authors recruited participants among initially unemployed individuals who participated in the entrepreneurial program aimed at creating self-employment. Since entrepreneurs are expected to have specific personal characteristics important for performance, the authors assessed proactive coping as the key factor for self-employment intention.

Findings

The results depicted proactive coping as crucial in performing own ventures in the long run, which suggests that self-employment intention may change over time.

Practical implications

Proactive coping is particularly appropriate for self-employed at any stage of the entrepreneurial process because it maintains the intention to perform own business. Thus, the findings underline the need for proactive coping training for entrepreneurs, particularly those previously unemployed.

Originality/value

As the self-employment intention may differ in time, the importance of being proactive in operating small businesses increases.
The impact of mutual funds’ ESG scores on their financial performance during the COVID-19 pandemic. A data envelopment analysis
Authors: Tampakoudis Ioannis , Kiosses Nikolaos , Petridis Konstantinos
Published: April 2023

Purpose

The purpose of this study is to evaluate the performance of mutual funds during the COVID-19 pandemic with environmental, social and governance (ESG) criteria. The main research question is whether mutual fund performance differs with respect to the level of the mutual fund’s ESG score.

Design/methodology/approach

The data set contains global fund data, and mutual fund performance is analyzed using two types of data envelopment analysis (DEA) models: the DEA portfolio index (DPEI) and the range direction measure (RDM) DEA. Propensity score matching and logistic regression are also applied.

Findings

The results reveal that: nonequity mutual funds present significantly higher performance compared to the performance of equity mutual funds; mutual funds with high ESG scores are associated with significantly higher performance compared to those with low to medium ESG scores; funds with high ESG scores experience higher performance irrespective of their type; and efficiency scores derived from the RDM DEA are significantly higher than those derived from the DPEI model.

Research limitations/implications

Investors, fund managers and market participants can benefit from the findings of this study and improve their investment decision-making process, including more sustainable funds in their portfolios. Regulators and policymakers should further promote or even require the inclusion of more sustainable investments in the financial products offered by institutional investors. The main limitation of the study is related to data availability regarding the ESG score of mutual funds.

Originality/value

To the best of the authors’ knowledge, this is the first study that provides robust evidence in support of a positive association between ESG scores and mutual fund performance during the pandemic-induced crisis applying a DEA methodology.
Enterprise digitalization, employee digital literacy and R&D cooperation: the moderating role of organizational inertia
Authors: Lei Hui , Tang Shiyi , Zhao Yuxin , Chen Shou
Published: April 2023

Purpose

This study aims to explore the effect of digitalization on the promotion of enterprise R&D cooperation, and it analyzes the microimpact mechanism and boundary conditions of enterprise digitalization on enterprise R&D cooperation.

Design/methodology/approach

Based on survey data sourced from the World Bank Enterprise Surveys of the business environment of Chinese enterprises in 2012, this study applies multiple regression methods to test theoretical hypotheses.

Findings

Enterprise digitalization positively affects the breadth and intensity of enterprise R&D cooperation. Employees’ digital literacy plays an intermediary role between enterprise digitalization and enterprise R&D cooperation. The subordinate attributes of enterprises weaken the positive relationship between enterprise digitalization and the breadth and intensity of enterprise R&D cooperation. The shareholding of state-owned enterprises reinforces the positive relationship between digitalization and the intensity of enterprise R&D cooperation. However, such shareholding shows no significant regulatory effect on digitalization and the breadth of enterprise R&D cooperation.

Originality/value

Focusing on the digital transformation of the enterprise, this study discusses its impact mechanism on enterprise R&D cooperation, including the impact on the intensity and breadth of R&D cooperation. The study further examines the regulatory effect of organizational inertia on enterprise digital and R&D cooperation from two aspects: resource rigidity and routine rigidity. It emphasizes the significance of the digital literacy of employees in enterprise digitalization and discusses the micromechanism of enterprise digitalization and enterprise R&D cooperation.
The role of crowdfunding in endorsing responsible open innovation for shared value co-creation: a systematic literature review
Authors: Cillo Valentina , Borin Elena , Thomas Asha , Chaturvedi Anurag , Faggioni Francesca
Published: April 2023

Purpose

This paper aims to investigate the intersection between crowdfunding (CF), open innovation (OI) and responsible innovation (RI) and identify the emerging trends and gaps in research and new paths for CF research in the future. In addition, this paper proposes a conceptual framework and propositions.

Design/methodology/approach

This paper is structured in line with the systematic literature review protocol. After reading all the titles, keywords and abstracts, 172 papers focused on OI and RI were selected for this research. Finally, 27 papers that are based on dimensions related to responsible OI were selected for the study.

Findings

Due to CF's multidisciplinary nature, the scientific literature on the role of CF in endorsing responsible OI for shared value co-creation appears fragmented and redundant. Several emerging trends and gaps of research and new paths for CF research in the future arise regarding research methodology and theoretical perspective.

Originality/value

To the best of the authors' knowledge, this is the first study investigating the intersection between CF OI and RI.
Hedging potentials of green investments against climate and oil market risks
Authors: Adediran Idris A. , Swaray Raymond , Orekoya Aminat O. , Kabir Balikis A.
Published: April 2023

Purpose

This study aims to examine the ability of clean energy stocks to provide cover for investors against market risks related to climate change and disturbances in the oil market.

Design/methodology/approach

The study adopts the feasible quasi generalized least squares technique to estimate a predictive model based on Westerlund and Narayan’s (2015) approach to evaluating the hedging effectiveness of clean energy stocks. The out-of-sample forecast evaluations of the oil risk-based and climate risk-based clean energy predictive models are explored using Clark and West’s model (2007) and a modified Diebold & Mariano forecast evaluation test for nested and non-nested models, respectively.

Findings

The study finds ample evidence that clean energy stocks may hedge against oil market risks. This result is robust to alternative measures of oil risk and holds when applied to data from the COVID-19 pandemic. In contrast, the hedging effectiveness of clean energy against climate risks is limited to 4 of the 6 clean energy indices and restricted to climate risk measured with climate policy uncertainty.

Originality/value

The study contributes to the literature by providing extensive analysis of hedging effectiveness of several clean energy indices (global, the United States (US), Europe and Asia) and sectoral clean energy indices (solar and wind) against oil market and climate risks using various measures of oil risk (WTI (West Texas intermediate) and Brent volatility) and climate risk (climate policy uncertainty and energy and environmental regulation) as predictors. It also conducts forecast evaluations of the clean energy predictive models for nested and non-nested models.
A comparison of public perceptions of cisgender male and transgender male stalking perpetrators
Authors: Cook Lydia Caroline , Duff Simon C.
Published: April 2023

Purpose

The purpose of this study is to compare perceptions of male cisgender and male transgender stalking perpetrators. There present study compared participants’ perceptions of whether behaviour constituted stalking, posed a threat, had a risk of violence and required police intervention when the perpetrator was transgender or cisgender. The present study also sought to replicate the prior-relationship misconception in stalking literature and to investigate whether perceptions of transgender perpetrators changed based on the age and gender of the perceiver.

Design/methodology/approach

Participants read vignettes outlining the relationship between victim and perpetrator as well as a description of the stalking behaviours. Participants then reported their perceptions of the four dependent variables on Likert-type scales.

Findings

The prior-relationship misconception was replicated. There were no significant differences in perceptions of transgender and cisgender perpetrators across the four dependent variables. There were also no significant differences in perceptions based on the gender of the perceiver. Contrary to expectations, older participants perceived transgender perpetrators as less threatening than younger participants.

Research limitations/implications

The prior-relationship misconception is robust to gender identity of the perpetrator. The participants in the present study seemed to make judgements based on stalking behaviour and not the gender identity of the perpetrator. Future research should replicate this study with more severe stalking behaviours and with greater variation in gender identity.

Originality/value

To the best of the authors’ knowledge, this study is the first to compare perceptions of cisgender and transgender males in the context of stalking perpetration. There is also consideration of how the demographics of the perceiver could impact these perceptions. This study also contributes to research on the prior-relationship misconception by demonstrating that the misconception is robust to gender identification of the perpetrator.
The abuse of the beneficial ownership of trusts to conceal assets in insolvency and divorce proceedings: a South African study
Authors: Dubber Andrea , Van Graan Constant , Groenewald Andre
Published: April 2023

Purpose

Previous research has indicated that trusts are used to commit various economic crimes, but limited studies examine the exact method of how trusts are abused. This paper aims to determine how trusts are abused to conceal assets in insolvency and divorce proceedings. Apart from discussing how fraudulent trusts are evaluated by South African courts, two court cases will also be analysed to determine how trusts have been abused in the past to conceal assets in insolvency and divorce proceedings.

Design/methodology/approach

The methodology used is a literature study, predominantly using court cases and relevant statutes as the primary sources of information. The difference between a sham and alter ego trust is discussed, whereafter two court cases are dissected to identify how trusts have been abused to conceal assets.

Findings

The study found that trusts can be abused in different ways to conceal assets in insolvency and divorce proceedings. This can vary from the way the trust is established to the way the trust is used. But trusts are particularly susceptible to abuse when there is no separation between the ownership and enjoyment of trust assets, and the trust lacks independent trustees.

Originality/value

The research finding can be used to better understand how trusts are abused in divorce and insolvency proceedings.
How does knowledge hiding play a role in the relationship between leader–member exchange differentiation and employee creativity? A cross-level model
Authors: Liao Ganli , Li Mengyao , Li Yi , Yin Jielin
Published: April 2023

Purpose

Employees’ knowledge management, which influences creativity, is a pivotal resource in organizational innovation activities, as it helps activate the knowledge resource pool and improves knowledge flow. Using social information processing theory, this study aims to construct a cross-level model to examine how knowledge hiding plays a role in the relationship between leader–member exchange differentiation (LMXD) and employee creativity.

Design/methodology/approach

This study surveyed 754 leader–employee matching samples from 127 teams in China innovation enterprises at two time points. Confirmatory factor analysis, convergent analysis, hierarchical regression analysis and bootstrapping method by SPSS and AMOS were used to test the hypotheses.

Findings

The empirical results demonstrate the cross-level model’s efficiency and reveal the following findings: Team-level LMXD is negatively related to employee creativity, whereas it is positively related to knowledge hiding; knowledge hiding is negatively associated with employee creativity; thus, knowledge hiding plays a mediating role in the relationships between them.

Originality/value

Based on the knowledge-hiding perspective, this study analyzed an underlying mechanism between LMXD and employee creativity, thereby further enriching the literature on the influence of knowledge management. This proposed connection has not been established previously. Moreover, the findings respond to the reasons for the inconsistent conclusions of previous literature on the cross-level relationship between LMXD and employee creativity based on the social information processing theory. It thus clarifies the cross-level influence path, as well as provides a theoretical basis for further research on the relationship between the two.
Peer stigma, consequences, and anti-stigma strategies in adolescents with mental disorders: a qualitative investigation
Authors: Aiyub Aiyub , Jannah Syarifah Rauzatul , Marthoenis Marthoenis , Abdullah Asnawi , Sofyan Hizir
Published: April 2023

Purpose

This paper aims to investigate the local perspectives, based on culture and beliefs about peer stigma, consequences and strategies to reduce mental health stigma among adolescents in Indonesia.

Design/methodology/approach

This study included 30 participants, including students, teachers, health professionals and lecturers. Two sessions of focus group discussions and 14 sessions of in-depth interviews were performed to collect the data. A qualitative content analysis was carried out, and some related themes and sub-themes were explored.

Findings

This study found that peer stigma was prevalent and negatively impacted the psychological, social and intellectual development of adolescents with mental disorders (MD) in Indonesian society. Five strategies to tackle peer stigma were proposed, including increasing mental health literacy (MHL), reducing the harmful effects of stigma, fostering a supportive social environment, expanding access to and improving the quality of mental health care and advocating for public health policies.

Research limitations/implications

More qualitative research on the experiences and perspectives of victims, perpetrators and society concerning mental health stigma in adolescents is required to fully understand why stigma arises, what causative factors and repercussions it has, as well as how to deal with it.

Practical implications

Peer stigma still exists among adolescents. It has negative impacts on their mental and psychological well-being. MHL, social environment, the harmful effects of stigma, as well as mental health access and policy were concerns of this study. A school is a place where adolescents spend most of their social time. Schools play a vital part in the stigma-reduction program.

Originality/value

Mental health stigma among adolescents with MD is an issue that has potentially hindered mental health recovery. Anti-stigma intervention based on local perspectives is valuable in increasing the effectiveness and acceptance of interventions.
Performance measurement in aircraft maintenance – literature review
Authors: Timjerdine Mohammed
Published: April 2023

Purpose

This research aims to review relevant documentation on performance measurement in aircraft maintenance. The approaches and models used to measure and manage aircraft maintenance performance in civilian and military contexts are classified and examined during this process. Based on the results of this study, future directions and research topics are identified.

Design/methodology/approach

The review included an initial database of 200 publications published over the past 20 years. Published work included contributions from institutions, companies, and scholars.

Findings

The present literature review showed the distribution of themes related to measuring and improving of aviation maintenance performance. These areas and themes cover the perspectives of the customer, technicians and managers and range from the effective management of material resources, the contribution of mathematical models and the help of information systems, and finally, the involvement of the human factor. Thus, given this documentary base, a conceptual framework, which retraces the different operational and organizational facets of the evolution of maintenance performance management, is presented.

Research limitations/implications

Based on the results obtained, the measurement of performance in aeronautical maintenance requires more research and the development of theoretical models.

Practical implications

Findings from this investigation have relevant implications for aircraft maintenance. In this context, it is essential to understand the different approaches to “performance measurement” and management used in airlines and maintenance centers.

Originality/value

Given the competitiveness of the aviation sector, it is important to understand the types and scope of different approaches and models used to manage and measure aeronautical maintenance performance in civilian and military operational contexts.
Research trends on smart urban governance in Asia: a bibliometric analysis
Authors: Sulistyaningsih Tri , Loilatu Mohammad Jafar , Roziqin Ali
Published: April 2023

Purpose

Smart urban governance research has progressed over the past few decades following changes and increasingly complicated city management difficulties. Therefore, the purpose of this paper is to use a scoping review and bibliometric analysis to examine all the publications on smart urban governance, especially in Asia.

Design/methodology/approach

A total of 1,900 smart urban governance articles indexed in the Scopus database was analyzed through scoping review and bibliometric analysis. The articles were analyzed by the number of publications per year, contributing countries, subject areas, authors, cited documents, related issues and cited papers. Furthermore, VOSviewer was used to provide a visual analysis of the co-occurrence of keywords.

Findings

This study indicated that urban smart governance publications continue to increase yearly. Even though the area of analysis is Asia, the USA and China seriously contributed to the analysis. Therefore, the topic of smart urban governance has become a discussion for scholars in the international. From the Scopus database analysis, the top three subject areas are social sciences (28%), environmental science (20%) and medicine (16%). The synthesis using bibliometric analysis by VOSviewer obtained 13 clusters.

Research limitations/implications

This study only focuses on the Scopus database and one specific topic, using one bibliometric analysis tool. Meanwhile, national and international index databases are not used.

Originality/value

This paper examined publication trends on smart urban governance. This paper provided a comprehensive analysis of topic-specific knowledge areas based on previous studies. Additionally, this paper suggested the direction of the development of smart urban governance in the future.
When leaders and peers positively facilitate creativity: the moderating role of absorptive capacity
Authors: Thanh Bui Thi , Tran Lobel Trong Thuy
Published: April 2023

Purpose

This article explores the complementarity between leader encouragement of creativity and knowledge-sharing among peers in enhancing employee creativity in the hotel context. The authors further examine the role of absorptive capability in setting a contextual condition under which creativity affects employee performance.

Design/methodology/approach

A web-based survey and face-to-face interviews were a means of two-round data collection while using a partial least squares technique for model estimation.

Findings

An analysis of 277 employees showed that leader encouragement and knowledge-sharing are important for creativity to drive performance. At high levels of absorptive capacity, employee performance increases rapidly as creativity increases.

Research limitations/implications

This article extends how the complementarity between leader encouragement and knowledge-sharing plays an important role in explaining employee creativity and performance under the boundary condition of absorptive capacity.

Practical implications

Organizational managers could embrace a future creativity–performance strategy by developing absorptive capacity with reward systems to optimize employee performance.

Originality/value

This article substantiates the role of leader encouragement and knowledge-sharing in enhancing the relationship between employee creativity and performance. The strength of this relationship is dependent on the positive moderation of absorptive capacity.
Influence of big data adoption on sustainable marketing and operation of SMEs: a hybrid approach of SEM-ANN
Authors: Baig Maria Ijaz , Yadegaridehkordi Elaheh , Nizam Bin Md Nasir Mohd Hairul
Published: April 2023

Purpose

This research aimed to analyze and prioritize the factors affecting sustainable marketing (SM) and sustainable operation (SO) of manufacturing small and medium-sized enterprises SMEs through big data adoption (BDA).

Design/methodology/approach

The technology-organization-environment (TOE) framework was used as a theoretical base and data were gathered from manufacturing SMEs in Malaysia. The 159 questionnaire replies of chief executive officer (CEO)/managers were analyzed using a hybrid approach of structural equation modeling-artificial neural network (SEM-ANN).

Findings

The findings of this study showed that perceived benefits (PB), technological complexity (TC), organization's resources (OR), organization's management support (OMS) and government legislation (GL) are the factors that influence BDA and promote SM and SO. The findings of ANN showed that a perceived benefit is the most important factor, followed by OMS.

Practical implications

The findings of this study can assist SMEs managers in making strategic decisions and improving sustainable performance and thus contribute to overall economic development.

Originality/value

The manufacturing industry is under immense pressure to integrate sustainable practices for long-term success. BDA can assist industries in aligning industries' operational capabilities. The majority of the current research have mainly emphasized on BDA in corporations. However, the associations between BDA and sustainable performance of manufacturing SMEs have been less explored. To address this issue, this study developed a theoretical model and examined the influence of BDA on SM and SO of manufacturing SMEs. Meanwhile, the hybrid methodological approach can help to uncover both linear and non-linear relationships better.
Impact of coronavirus disease 2019 (COVID‐19) vaccination on menstrual bleeding quantity: An observational cohort study
Authors: Darney Blair G. , Boniface Emily R. , Van Lamsweerde Agathe , Han Leo , Matteson Kristen A. , Cameron Sharon , Male Victoria , Acuna Juan , Benhar Eleonora , Pearson Jack T. , Edelman Alison
Published: April 2023

Objective

To assess whether coronavirus disease 2019 (COVID‐19) vaccination impacts menstrual bleeding quantity.

Design

Retrospective cohort.

Setting

Five global regions.

Population

Vaccinated and unvaccinated individuals with regular menstrual cycles using the digital fertility‐awareness application Natural Cycles°.

Methods

We used prospectively collected menstrual cycle data, multivariable longitudinal Poisson generalised estimating equation (GEE) models and multivariable multinomial logistic regression models to calculate the adjusted difference between vaccination groups. All regression models were adjusted for confounding factors.

Main outcome measures

The mean number of heavy bleeding days (fewer, no change or more) and changes in bleeding quantity (less, no change or more) at three time points (first dose, second dose and post‐exposure menses).

Results

We included 9555 individuals (7401 vaccinated and 2154 unvaccinated). About two‐thirds of individuals reported no change in the number of heavy bleeding days, regardless of vaccination status. After adjusting for confounding factors, there were no significant differences in the number of heavy bleeding days by vaccination status. A larger proportion of vaccinated individuals experienced an increase in total bleeding quantity (34.5% unvaccinated, 38.4% vaccinated; adjusted difference 4.0%, 99.2% CI 0.7%–7.2%). This translates to an estimated 40 additional people per 1000 individuals with normal menstrual cycles who experience a greater total bleeding quantity following the first vaccine dose' suffice. Differences resolved in the cycle post‐exposure.

Conclusions

A small increase in the probability of greater total bleeding quantity occurred following the first COVID‐19 vaccine dose, which resolved in the cycle after the post‐vaccination cycle. The total number of heavy bleeding days did not differ by vaccination status. Our findings can reassure the public that any changes are small and transient.
Physical activity is low before and during hospitalisation: A secondary observational study in older Australian general medical patients
Authors: D'Souza Aruska N. , Granger Catherine L. , Kay Jacqueline E. , Said Catherine M.
Published: April 2023

Objectives

To quantify physical activity in patients prior to and during an acute general medical hospital admission and explore relationships between mobility, pre‐ and in‐hospital physical activity.

Methods

This was a prospective, single‐site secondary observational study conducted on general medical wards at a tertiary hospital. Prehospital physical activity was measured via the Physical Activity Scale for the Elderly (PASE; scored 0–400); in‐hospital physical activity was measured via accelerometry (time at metabolic equivalents [METs] > 1.5), and mobility was measured via the de Morton Mobility Index (DEMMI). Associations were determined via Spearman's correlations.

Results

Forty‐six participants were included: median age 81 [76–85] years, 59% female, DEMMI on admission 39 [30–49]. Prehospital physical activity was low (PASE median 27.1 [1.6–61.9]). In‐hospital physical activity was also low (0.5 [0.2–1.5] hours per day being physically active and 54 [16–194] steps per day taken). No statistically significant relationships existed between pre‐ and in‐hospital physical activity (Spearman's rho (ρ) 0.24, 95% CI −0.08–0.53, p = 0.07). However, physical activity levels in the pre‐ and in‐hospital settings were positively associated with patients' mobility in‐hospital (Spearman's ρ 0.44, 95% CI 0.15–0.67, p = 0.002; Spearman's ρ 0.40, 95% CI 0.08–0.645, p = 0.011 respectively).

Conclusions

Physical activity is low both before and during a general medical admission. Assessment of usual physical activity patterns should be part of the clinical assessment of patients in general medicine; however, the low activity levels observed indicate a need for valid and reliable tools suitable for an older, frail cohort. Findings will inform the development of physical activity guidelines during hospitalisation.
Anti‐Apoptotic and Pro‐Apoptotic Bcl‐2 Family Proteins in Peri‐Implant Diseases
Authors: Yilmaz Dogukan , Gürsoy Mervi , Gürsoy Ulvi Kahraman
Published: April 2023

Objectives

Intrinsic apoptosis, which is regulated by Bcl‐2 family proteins, has an important role in chronic inflammatory diseases. The aim of the study was to identify the tissue levels and ratios of anti‐ and pro‐apoptotic Bcl‐2 family proteins in peri‐implant diseases.

Materials and Methods

Twenty‐three individuals with peri‐implant mucositis, 25 individuals with peri‐implantitis, and 24 controls were included. The following clinical parameters were recorded: keratinized mucosa width, modified bleeding index, probing depth, modified plaque index, modified gingival index, and keratinized tissue thickness. Marginal alveolar bone assessments were performed by a software program. Granulation tissues were collected during treatments of peri‐implant diseases. The control tissue samples were collected during the second stage of implant surgery. The tissue levels of Bcl‐2 family pro‐apoptotic (Bak, Bax, active caspase‐3) and anti‐apoptotic (Bcl‐2, Bcl‐xL, Mcl‐1) proteins were determined by multiplex immunoassay method.

Results

The pro‐apoptotic proteins; Bak, Bax and anti‐apoptotic proteins Bcl‐2, Bcl‐xL, Mcl‐1 were detected significantly higher in controls compared with patients with peri‐implant mucositis and peri‐implantitis (p < .001), respectively. The higher active caspase‐3 levels were also detected in controls in comparison with peri‐implant mucositis (p = .018) and peri‐implantitis (p = .005). Anti‐apoptotic: pro‐apoptotic protein ratios (Bcl‐2:Bax, p < .001; Bcl‐2:Bak, p = .01; Bcl‐xL: Bax, p = .006, Bcl‐xL:Bak, p = .011; Mcl‐1:Bak, p < .001) were significantly increased in diseased groups. A positive correlation was demonstrated between clinical variables and anti‐apoptotic: pro‐apoptotic ratios.

Conclusion

Our findings indicate dysregulation of the Bcl‐2 family proteins in peri‐implant diseases. This unregulated response may disturb the homeostasis of peri‐implant tissue.
Inhibition of TANK‐binding kinase1 attenuates the astrocyte‐mediated neuroinflammatory response through YAP signaling after spinal cord injury
Authors: Zhang Wenbin , Jia Mengxian , Lian Jiashu , Lu Sheng , Zhou Jian , Fan Ziwei , Zhu Zhoule , He Yaozhi , Huang Changgang , Zhu Mingyu , Wang Jian , Wang Ying , Huang Zhihui , Teng Honglin
Published: April 2023

Aims

TANK‐binding kinase 1 (TBK1) is involved in regulating the pathological process of a variety of inflammatory diseases in the central nervous system. However, its role and underlying molecular mechanisms in spinal cord injury (SCI) remain largely unknown.

Methods

We employed the TBK1 inhibitor amlexanox (ALX) to address this question. An in vivo clip‐compressive SCI model and in vitro lipopolysaccharide (LPS)‐induced astrocyte inflammation model were established to examine the effects of TBK1 inhibition on the expression of proinflammatory cytokines.

Results

In this study, we found that TBK1 and TBK1‐medicated innate immune pathways, such as TBK1/IRF3 and noncanonical NF‐κB signaling, were activated in astrocytes and neurons after SCI. Furthermore, inhibition of TBK1 by ALX alleviated neuroinflammation response, reduced the loss of motor neurons, and improved the functional recovery after SCI. Mechanistically, inhibition of TBK1 activity promoted the activation of the noncanonical NF‐κB signaling pathway and inhibited p‐IRF3 activity in LPS‐induced astrocytes, and the TBK1 activity was required for astrocytic activation through yes‐associated protein (YAP) signaling after SCI and in LPS‐induced astrocytes inflammation model.

Conclusion

TBK1‐medicated innate immune pathway in astrocytes through YAP signaling plays an important role in the pathogenesis of SCI and inhibition of TBK1 may be a potential therapeutic drug for SCI.
Memory characteristics in mesial temporal lobe epilepsy: Insights from an eye tracking memory game and neuropsychological assessments
Authors: Xiao Ling , Zhu Guangpu , Huang Kailing , Wen Shirui , Feng Li , Li Beibin , Xiao Bo , Liu Ding , Wang Quan
Published: April 2023

Aims

To compare different patterns of memory impairment in patients with two subtypes of mesial temporal lobe epilepsy (MTLE) and healthy controls.

Methods

Thirty‐five healthy controls and 41 patients with MTLE were recruited, of which 25 patients were diagnosed as hippocampal sclerosis (HS‐MTLE), and the rest 16 patients were lesion‐negative (MRI‐neg MTLE). Participants completed the Wechsler memory assessment and a short‐term memory game on an automated computer‐based memory assessment platform with an eye tracker.

Results

Both the MRI‐neg MTLE and HS‐MTLE groups took longer time to complete the short‐term memory game than healthy controls (p < 0.001, Cohen's d = 1.087; p = 0.047, Cohen's d = 0.787). During the memory encoding phase, the MRI‐neg MTLE group spent significantly shorter time than healthy controls on the difficult levels with three (p = 0.004, Cohen's d = 0.993) and four targets (p = 0.016, Cohen's d = 0.858). During the memory decoding phase, the HS‐MTLE group spent less time looking on the targets compared to controls when recalling and finding four targets (p = 0.004, Cohen's d = −0.793), while the MRI‐neg MTLE group spent significantly longer time on the distractors and shorter time on the region of interests (ROIs) for all difficulty levels (all p < 0.05) than controls. Furthermore, the eye tracking data were correlated with the scores of the Wechsler Memory Scale after Bonferroni correction (p < 0.05).

Conclusion

Patients with MRI‐neg MTLE demonstrate impaired memory mostly due to attention deficits, while those with HS‐MTLE show memory impairment with relative sparing of attention. Eye tracking technology has the potential of facilitating the investigation of the mechanism of memory defect in MTLE and can serve as a supplementary neuropsychological tool for clinical diagnosis and long‐term monitoring.