bluuebunny/crossref_metadata_2025 huggingface dataset:
A 10-year registry-based incidence, mortality, and survival analysis of colorectal cancer in Northern Malaysia
Authors: Ismail Ibtisam , Chan Huan Keat , Aiman Soelar Shahrul , Muhammad Radzi Abu Hassan
Published: July 2021

Introduction:

Colorectal cancer (CRC) is the third most common cancer globally. This study aimed to determine the incidence, mortality, and survival rates of CRC in northern Malaysia over the last decade.

Materials and Methods:

This was a registry-based, cross-sectional study. All the CRC patients seeking treatment from any of the 21 hospitals located in northern Malaysia between 2008 and 2017 were included in this study. Both the incidence and mortality rates were expressed as the number of cases per 100,000. The time series analysis was performed to assess the changes in the age-standardized incidence and mortality rates (ASIR and ASMR) of CRC, while the Cox regression analysis was used to detect the differences in the mortality risk between subgroups of CRC patients.

Results:

Of the 5746 CRC patients identified, approximately 40% were diagnosed only at Stages III and IV of the disease. Although the ASIR of CRC was stable and narrowly ranged from 17.03 to 20.01 per 100,000 (P = 0.775), the ASMR of CRC significantly reduced from 12.73 per 100,000 in 2008 to 2.99 per 100,000 in 2017 (P < 0.001). Besides increasing with age and the severity of the disease, the mortality risk was significantly higher in men (adjusted hazard ratio [HR]: 1.18; 95% confidence interval [CI]: 1.02, 1.17) and the Malay ethnic group (adjusted HR: 1.33; 95% CI, 1.08, 1.64).

Conclusion:

While efforts had been made to promote the timely treatment of CRC, it is encouraging to note a downtrend in its mortality rate. However, there is still a need to upscale the CRC screening going forward.
Induction of apoptosis and suppression of Ras gene expression in MCF human breast cancer cells
Authors: Saremi Sadegh , Kolahi Maryam , Tabandeh Mohammad Reza , Hashemitabar Mahmoud
Published: July 2021

Breast cancer is the leading invasive cancer in women globally. This study aimed at evaluating the anti-apoptotic activity of p-Coumaric acid (PCA) on MCF-7 breast cancer cell line. Experiments were conducted in which the MCF-7 cell line was treated with PCA. which showed decreased cell viability, increased lactate dehydrogenase activity, and caspase-3 activation. The results were evaluated with real-time polymerase chain reaction which revealed that PCA reduced the amount of H-Ras and K-Ras transcript in MCF-7 breast cancer cells. In the presence of PCA there was a significant increase in the levels of mRNA gene Bax and late apoptotic cells which was dose dependent. It also retarded the relative expression of antiapoptotic gene, Bcl2 in treated cells. The results suggest that PCA exhibits anti-cancer properties against MCF-7 cells. PCA inhibited the growth of MCF7 cell. The optimum concentration of PCA was 75–150 mM. PCA can inhibit the growth of MCF-7 cells by reducing Ras expression and inducing cell apoptosis. Our results suggest that PCA could prove valuable in the search for possible inhibitors of Ras oncogene functionality and gain further support for its potential utilization in the treatment of patients with breast cancer. PCA is safe and could complement current treatments employed for the disease.
Convexity of balls in outer space
Authors: Qing Yulan , Rafi Kasra
Published: July 2021

In this paper we study the convexity properties of geodesics and balls in Outer space equipped with the Lipschitz metric. We introduce a class of geodesics called balanced folding paths and show that, for every loop

\alpha

, the length of

\alpha

along a balanced folding path is not larger than the maximum of its lengths at the endpoints. This implies that out-going balls are weakly convex. We then show that these results are sharp by providing several counter examples.
Szegő’s theorem for canonical systems: the Arov gauge and a sum rule
Authors: Damanik David , Eichinger Benjamin , Yuditskii Peter
Published: July 2021

We consider canonical systems and investigate the Szegő class, which is defined via the finiteness of the associated entropy functional. Noting that the canonical system may be studied in a variety of gauges, we choose to work in the Arov gauge, in which we prove that the entropy integral is equal to an integral involving the coefficients of the canonical system. This sum rule provides a spectral theory gem in the sense proposed by Barry Simon.
“I Am Not Punjabi, My Parents Are”: Degradation of the Language of Dominant Majority
Authors: Haidar Sham , Wali Tehreem , Tahir Tehreem , Parveen Mehwish
Published: July 2021

Due to social and geographical mobility and globalization, many minority languages in the world are pushed to the periphery. Reasons for such a trend differ among languages. In the case of the Punjabi language, despite being spoken by a major portion of the population, the speakers are gradually disowning it. Considering this gradual shift, the present study explores the predicament of the Punjabi language. The study uses phenomenological design and collects data from Punjabi ethnic students in four different universities in Islamabad. The study uses semi-structured interviews, TV shows, and natural conversations. Findings reveal that the Punjabi speakers themselves disown their language as well as Punjabi identity due to social, economic, religious, and political reasons. Especially women avoid the language more, they do not speak Punjabi with their children, and they reject their Punjabi identity.
Network for Supporting Education of Foreign Children During Covid-19: Language Assessments as a Tool for Promoting Community Integration
Authors: Sawada Hiroko , Inoue Rizu
Published: July 2021

The rising number of foreign residents in Japan has caused the number of children with foreign backgrounds in Japanese schools to increase. The present Japanese education system does not adequately support children whose mother language is not Japanese, and their educational problems have turned into social issues. We have conducted an action research project in collaboration with several schools and one university to determine how to develop a support system through online media that would soften the impact of the COVID-19 pandemic. We argue that language assessment is the key to driving the project and sharing the results of the assessment analysis with all project participants works effectively to promote collaboration between schools, families, and the university.
On p/q-recognisable sets
Authors: Marsault Victor
Published: July 2021

Let p/q be a rational number. Numeration in base p/q is defined by a function
that evaluates each finite word over A_p={0,1,...,p-1} to some rational number.
We let N_p/q denote the image of this evaluation function. In particular, N_p/q
contains all nonnegative integers and the literature on base p/q usually
focuses on the set of words that are evaluated to nonnegative integers; it is a
rather chaotic language which is not context-free. On the contrary, we study
here the subsets of (N_p/q)^d that are p/q-recognisable, i.e. realised by
finite automata over (A_p)^d. First, we give a characterisation of these sets
as those definable in a first-order logic, similar to the one given by the
B\"uchi-Bruy\`ere Theorem for integer bases numeration systems. Second, we show
that the natural order relation and the modulo-q operator are not
p/q-recognisable.
Relating Apartness and Bisimulation
Authors: Geuvers Herman , Jacobs Bart
Published: July 2021

A bisimulation for a coalgebra of a functor on the category of sets can be
described via a coalgebra in the category of relations, of a lifted functor. A
final coalgebra then gives rise to the coinduction principle, which states that
two bisimilar elements are equal. For polynomial functors, this leads to
well-known descriptions. In the present paper we look at the dual notion of
"apartness". Intuitively, two elements are apart if there is a positive way to
distinguish them. Phrased differently: two elements are apart if and only if
they are not bisimilar. Since apartness is an inductive notion, described by a
least fixed point, we can give a proof system, to derive that two elements are
apart. This proof system has derivation rules and two elements are apart if and
only if there is a finite derivation (using the rules) of this fact.
We study apartness versus bisimulation in two separate ways. First, for weak
forms of bisimulation on labelled transition systems, where silent (tau) steps
are included, we define an apartness notion that corresponds to weak
bisimulation and another apartness that corresponds to branching bisimulation.
The rules for apartness can be used to show that two states of a labelled
transition system are not branching bismilar. To support the apartness view on
labelled transition systems, we cast a number of well-known properties of
branching bisimulation in terms of branching apartness and prove them. Next, we
also study the more general categorical situation and show that indeed,
apartness is the dual of bisimilarity in a precise categorical sense: apartness
is an initial algebra and gives rise to an induction principle. In this
analogy, we include the powerset functor, which gives a semantics to
non-deterministic choice in process-theory.
Continuous Dynamic Mapping of Cranial Nerve Pathways and Long Tracts Inside the Brainstem: Useful Technique of Intraoperative Neurophysiological Monitoring
Authors: Smolanka Volodymyr I. , Smolanka Andrey V. , Sechko Oleksandr S. , Herasymenko Olga S.
Published: July 2021

Surgery of intrinsic brainstem lesions is extremely dangerous, consequently the knowledge of anatomy and safe entry zones is extremely important. The technological progress was achieved with the widespread clinical use of intraoperative neurophysiological monitoring (IONM) which has proven to further improve the safety of operating on intrinsic brainstem lesions. The relevance of the study is conditioned by the fact that the tumor alters the normal anatomy and distorts the location of well-known landmarks and structures. In this regard, this paper is directed at identification of the placement of conductive pathways in the thickness of the brain stem and directly in the depth of the lesion (in the tumor or cavern), respectively to the surgical manipulations aimed at injury prevention. The results were achieved by a retrospective review of medical reports. The paper represents the results of surgical treatment of 42 patients with brainstem lesions, reviews the localization of the lesion and neurological status of patients, describes available methods of intraoperative monitoring (IOM) and on-line techniques for the brainstem surgery. The materials of the paper are of practical significance for the development of brainstem surgery with IONM modifications for wider and more comfortable use by neurosurgeons.
Markov Chain and Adaboost Image Saliency Detection Algorithm Based on Conditional Random Field
Authors: Lu Biao , Liang Nannan , Tan Chengfang , Pan Zhenggao
Published: July 2021

The traditional salient object detection algorithms are used to apply the underlying features and prior knowledge of the images. Based on conditional random field Markov chain and Adaboost image saliency detection technology, a saliency detection method is proposed to effectively reduce the error caused by the target approaching the edge, which mainly includes the use of absorption Markov chain model to generate the initial saliency map. In this model, the transition probability of each node is defined by the difference of color and texture between each super pixel, and the absorption time of the transition node is calculated as the significant value of each super pixel. A strong classifier optimization model based on Adaboost iterative algorithm is designed.The initial saliency map is processed by the classifier to obtain an optimized saliency map, which highlights the global contrast. In order to extract the saliency region of the final saliency map, a method using conditional random field is designed to segment and extract the saliency region. The results show that the saliency area detected by this method is prominent, the overall contour is clear and has high resolution. At the same time, this method has better performance in accuracy recall curve and histogram.
Face Detection and Recognition Method Based on Improved Convolutional Neural Network
Authors: Lu Zhengqiu , Zhou Chunliang , Xuyang Xuyang , Zhang Weipeng
Published: July 2021

with rapid development of deep learning technology, face recognition based on deep convolutional neural network becomes one of the main research methods. In order to solve the problems of information loss and equal treatment of each element in the input feature graph in the traditional pooling method of convolutional neural network, a face recognition algorithm based on convolutional neural network is proposed in this paper. First, MTCNN algorithm is used to detect the faces and do gray processing, and then a local weighted average pooling method based on local concern strategy is designed and a convolutional neural network based on VGG16 to recognize faces is constructed which is finally compared with common convolutional neural network. The experimental results show that this method has good face recognition accuracy in common face databases.
Conceptual problems of investigation and prevention of enforced disappearance of persons in the conditions of armed aggression
Authors: Mirkovets Dmytro , Atamanchuk Volodymyr , Marko Sergii , Dubivka Irina , Matsola Antonina
Published: July 2021

The article highlights the results of a study of the situation with official investigations into criminal offenses related to the enforced disappearance of persons in the context of armed aggression in eastern and southern Ukraine. The example of individual criminal proceedings presents some systemic problems that arise during the investigation of the facts of disappearance and suggests possible ways to solve them. There are several «blocks» of problems that lie in the field of criminal law, criminology, and criminal procedure. The points of view of scientists and practitioners on this problem are highlighted. It is concluded that Ukraine, in today’s conditions, needs to take measures aimed at improving the legal mechanisms of observance and protection of the right of persons staying in its territory to freedom from enforced disappearance, as well as intensifying law enforcement agencies to prompt, complete and impartial investigation of such facts, their proper qualification, search for victims, identification of those responsible for their disappearance, ensuring that victims receive timely and adequate compensation. The methodological basis for writing the article was a dialectical-materialist method, as well as the set of general scientific and special methods and techniques of scientific knowledge.
Features of detection and obtaining evidence of war crimes committed in the context of international armed conflict
Authors: Tataryn Ihor , Komissarchuk Yuliia , Dmytryk Yurii , Maistrenko Mariia , Rymarchuk Olha
Published: July 2021

The scientific article is devoted to a comprehensive understanding of international legal, procedural, and organizational problems of investigation of war crimes committed during the military conflict in the south and east of Ukraine. It develops the author's concept of investigation of war crimes committed during the armed conflict, scientifically substantiated theoretical provisions and specific patterns that are manifested in the field of legal support, organization of investigation, collection of evidence, methods of investigation of crimes of this type. It is concluded that there is a need to specify the components of war crimes in national legislation. Recommendations for further improvement of criminal and criminal procedure legislation of Ukraine in order to fulfill the state's international obligations in the field of international humanitarian law are given.
Comparative legal analysis of the anti-corruption policy in Ukraine and Poland
Authors: Zakharova Oleksandra , Harasymiv Olena , Sosnina Olga , Soroka Oleksandra , Zaiets Inesa
Published: July 2021

Effective counteraction to corruption remains relevant in some countries of Eastern Europe and the former Soviet Union, given that manifestations of corruption are a real obstacle to the realization of human rights, social justice, economic development and jeopardizes the proper functioning of a market economy. However, if such countries of the region, such as Poland, succeeded in ensuring the implementation of an effective anti-corruption policy, a number of post-Soviet countries, in particular Ukraine, faced significant obstacles to overcoming corruption and effectively implementing national anti-corruption policies. Therefore, within this article, a comparative legal analysis of the anti-corruption legislation of these countries has been carried out. The state of implementation of national anti-corruption policies and the formulated conclusions, which provide answers to the questions of improving the implementation of national anti-corruption policy, in particular Ukraine, are considered. Thus, the existence of modern national anti-corruption legislation that best meets the requirements and recommendations on which the state relies on relevant international treaties can be the key to successful anti-corruption efforts.
The police competence to ensure the rights and freedoms of citizens in modern society
Authors: Kubaienko Andrii , Okhrimenko Ivan , Kryzhanovska Olena , Kislitsyna Iryna , Hryshchenko Maksym
Published: July 2021

The aim of the study is to form a systematic approach to understanding and resolving a set of tasks of police activities that guarantee the rights and freedoms of citizens in modern society. It was concluded that the most typical negligence in this area includes violations of the rights and freedoms of citizens such as the installation of administrative actions against them without any sign of the crime, incorrect characterization of administrative infractions, the violation of the procedural order of administrative detention, cases of unjustified detention without preparation of reports, as well as exceeding the legal deadlines for administrative detention. Particular attention was paid to the set of means of appeal in proceedings concerning administrative offences, which may be referred to as the institution of the protection of citizens' rights and freedoms. Common European approaches to the legal regulation of policing and the influence of European Union law and decisions of the European Court of Human Rights on the guarantee of human rights and freedoms in policing were analyzed.
Criminal Liability for Provoking Bribery
Authors: Stepanenko Oksana , Stepanenko Andriy , Shepotko Maryna
Published: July 2021

In modern conditions of development of public relations complication of activity of law enforcement agencies is observed. This is due to new challenges in the law enforcement system, including the fight against high levels of the organization and the criminal professionalism of corrupt individuals. Because of this, it is challenging for operational units to identify specific facts of illegal actions with the help of operational and investigative measures. At the same time, the fight against crime by establishing high quantitative indicators of disclosure remains one of the principles of law enforcement in Ukraine, including sometimes deviating from those means established by law. Therefore, the problem of provoking bribery is relevant for scholars of the legislator and law enforcement. The object of the study is criminal liability for provoking bribery. The research methodology consists of such methods as the dialectical method, analytical method, historical method, method of analysis of legal documents, articles, and monographs, method of generalization, comparison, synthesis, and modeling method. The authors identified the features of such liability to clarify the problematic issues of qualification of provoking bribery, and to distinguish the distinctive features of prosecution from other types of crimes.
Intellectual property law in the field of sports: specifics of manifestations and features of legal regulation
Authors: Kharytonov Evgen , Kharytonova Olena , Tkalych Maxym , Bolokan Inna , Samilo Hanna , Tolmachevska Yuliia
Published: July 2021

The article aims to explore the relationships that arise with respect to intellectual property rights in sports. The objectives of the article are to establish points of contact between intellectual property law and sports, as well as a detailed analysis of relevant public relations in terms of intellectual property law and sports law. To achieve the objectives of the article, the authors used a number of scientific methods, among which the main methods are analysis, synthesis and comparative-legal method. The authors of the study concluded that modern sport is developing in close intertwining with intellectual property rights, because only in this way can a sports spectacle be conveyed to a wide range of spectators and consumers in a broad sense. In addition, the range of points of contact between intellectual property and sports law is constantly growing and such can now be called not only patents and trademarks in sports, but also copyright, "image" rights, know-how in sports and the like.
Systemic approach to the choice of optical methods of forensic examination of micro-objects
Authors: Havryliuk Liudmyla , Drozd Valentyna , Nenia Olena , Kyslyi Anatolii , Niebytov Andrii
Published: July 2021

The aim of the article is to analyze theoretical and methodological provisions related to the definition of directions and principles of implementation of a systematic approach to the use of optical research methods, in particular micro-objects. Subject of research is substantiation and formulation of the classification characteristics of such systematic approach, considering the requirements of forensic techniques. Methodology: The study applies such methods of scientific knowledge as dialectical method, system and structural method, logic and legal method, methods of systematic analysis, logical method. Research results: The article studies the problematic issues of a systematic approach to the choice of scientific and technical methods and means for micro-object examination. Practical consequences: The authors argue that optical methods of the micro-object examination require classifying and systematizing to provide a holistic view of their potentials, as well as the nature of the information that can be obtained about the object being examined. Value / originality: The analysis of clarified classification characteristics and requirements for examination methods in forensic science enables to propose the algorithm of the systemic approach to the creation of the open system classification of methods of micro-object examination and to make justified conclusions.
The modern law-making process: structure and main problems
Authors: Rumyantsev Mikhail B. , Turanin Vladislav Yu. , Sumenkov Sergey Yu. , Smirnova Marina G. , Ganaeva Esita E.
Published: July 2021

Through the dialectical method the objective of the article was to analyze the process of the elaboration of modern laws, considering their structure and main problems. There is a major structure and problems inherent in the modern law-making process described in the article. The structure of law-making comprises four parts: 1. Cognitive-analytical part; 2. Theoretical foundations of the legal norms and acts they dictate; 3. Validation of legal act or norm; 4. Monitoring of relevant rules and legal acts. The main legislative task is to draft legal norms that stimulate the active development of all parts of the State and society through a deep perception of all related processes, including those involving standard-setting. It is concluded that the main factor affecting the quality of legislation is the lack of a uniform legislative basis for the issuance of legal acts. There seems to be a real need to develop a uniform legislative act on the law-making process. The Code containing general and specific parts of each law must be developed.
The Role of Information Technologies in Improving Efficiency of Russian Customs Administration (Based on Results of Sociological Survey)
Authors: Kurochka Andrey , Popov Mikhail , Gaidareva Inna , Enina Victoria
Published: July 2021

As a research objective, the digital paradigm of economic and social development, in general, which defines the information strategy for the development of the Russian customs service and administration as necessary and priority, is analyzed. The methodological basis is based on the ideas and principles of an integrated information approach to the study of the customs service and the concept of "customs service", which treats the customs administration as service oriented. We also use additional theoretical approaches (socio-cultural and neo-institutional) as an explanatory model of the developmental characteristics of the Russian customs service. The empirical verification of conceptual attitudes in this study was conducted based on our 2020 expert sociological survey. In the survey, there were 269 employees of Rostov customs, which is structurally included in the Southern Customs Administration. The study concludes that the greater efficiency in the positive dynamics of the work of the Russian customs authorities is associated with the introduction of information technologies (especially electronic declaration). Consequently, the results of this study can be used to develop a strategy to overcome certain barriers in service.
Benefits of preserving cultural heritage and its impact on providing national security in Islamic countries
Authors: Etesam Zainab , Abdollahi Hamideh , Ebrahimi Alireza
Published: July 2021

One way to expand social, cultural, and religious communication and interaction in Islamic societies is to preserve cultural heritage and expand the tourism industry. Considering the emphasis of religious sources on the necessity of objective and theoretical study in history and the role that this heritage plays in preserving the identity and civilization of Islamic societies, its preservation is obligatory. Therefore, one of the essential programs that should be considered in this regard is the development of laws derived from books and traditions to preserve cultural heritage. In this article, the author examines the meaning of cultural heritage, national security, the effects of preserving cultural heritage, and methods of preserving this heritage in Islamic societies, takfiri groups to destroy cultural heritage, and their study based on religious sources. One of the critical research findings is the obligation to preserve the past’s cultural heritage in light of military, cultural, and economic security. The development of the tourism industry is not possible without preserving cultural heritage.
Dynamic Analysis of a Quadcopter Using PID, Adaptive and LQR Control Methods
Authors: ALTINÖRS Ayhan , KUZU Funda
Published: July 2021

In this study, different control methods for controlling the position and angle values for the quadcopter (UAV) that take off and land vertically are simulated with MATLAB/Simulink. First of all, a mathematical model was created with the Newton-Euler method, taking into account the dynamics of the quadcopter system. The focus of the study is to investigate the appropriate control method for the position control of the quadcopter. For the linear model of the quadcopter system, PID, LQR and Adaptive Control methods, and for the nonlinear model of the quadcopter system. PD Control simulation has been done. The mentioned control methods have been applied to the system and the control of the movement of the system in each axis has been examined. The obtained results are compared with each other to see the performance of the controllers and the most appropriate control method for the quadcopter was determined with comparisons and tracking scenarios.
Nuevas precisiones artísticas sobre el tesoro catedralicio hispalense: las dos grandes bandejas rococó donadas por el cardenal Delgado (y II)
Authors: Gil Pineda Francisco Manuel
Published: July 2021

El cordobés Damián de Castro, gran exponente de la platería rococó española en la centuria dieciochesca, realizó junto a otros artífices diferentes piezas para el cardenal Delgado y Venegas, arzobispo hispalense entre 1776 y 1781. Hoy muchas de estas piezas las podemos contemplar en las vitrinas de nuestro museo catedralicio, sin embargo la existencia en su tiempo de diferentes piezas similares produjo cierta confusión en su posterior identificación. En este nuevo trabajo intentaremos desentrañar las dudas sobre dos de las más vistosas piezas del tesoro de nuestro templo mayor: las dos bandejas de plata sobredorada que, ejecutadas en un exuberante y depurado rococó, deslumbran al visitante con sus fúlgidos destellos y atrevido diseño.
As Tecnologias da Informação e Comunicação (TICS) no contexto das práticas pedagógicas na sala de recursos multifuncionais
Authors: Barreto Mayra Ferreira
Published: July 2021

A presente pesquisa foi elaborada para servir como trabalho de conclusão de curso da especialização em “Atendimento Educacional Especializado”, ofertado pela Universidade Cândido Mendes (UCM), sob a orientação do professor Ms. Jan Carlos Dias de Santana. O trabalho apresenta reflexões a respeito da utilização do computador e da internet como ferramenta pedagógica na Sala de Recursos Multifuncionais (SRM), com a finalidade de compreender de que forma essas Tecnologias da Informação e Comunicação (TICs) podem facilitar o processo de aprendizagem de alunos com necessidades especiais. O trabalho tem como motivação valorizar às (TICs) como instrumentos que possibilitam à autonomia e à independência de estudantes da Educação Especial. Para realização dos objetivos almejados, a pesquisa utilizou os estudos de Alarcão (2011), Oliveira e Nascimento (2014), Santos e França (2014), Buniotti (2014), Fonseca (2015), Bravo (2016) e Fonseca (2017). Espera-se com este trabalho contribuir para o campo da educação especial e inclusiva, pois ainda são poucas as publicações nessa área de conhecimento.
Transcurso de la Acalasia durante más de una década de tratamientos fallidos, revisión bibliográfica y reporte de caso.
Authors: Naranjo Lara María José , Naranjo Lara Patricio Alexander , Haro Esparza David Alejandro , Maldonado Cajamarca Karen Andrea
Published: July 2021

La acalasia es un trastorno de la motilidad esofágica, de etiología desconocida que se caracteriza por el aperistaltismo en los dos tercios inferiores del cuerpo esofágico y la disminución o ausencia de relajación del esfínter esofágico inferior (EEI), suele comenzar de forma insidiosa, a menudo con síntomas subclínicos, que los médicos suelen diagnosticar erróneamente al principio.
Objetivo: El propósito de este artículo es analizar el caso de un paciente diagnosticado de Acalasia a los 11 años de edad, durante el transcurso de la patología durante 15 años, haciendo una revisión de literatura nacional e internacional.
Caso clínico: Paciente de 26 años de edad refiere disfagia para sólidos y líquidos, dolor retroesternal, pirosis desde los 11 años de edad es sometido a 3 intervenciones quirúrgicas (Miotomía de Heller + funduplicatura Dor) y 3 dilataciones, con la última cirugía refiere mejoría en la sintomatología sin embargo el dolor retroesternal y pirosis aún se mantienen.
Metodología: Se realizó una revisión bibliográfica de artículos científicos nacionales e internacionales de los últimos años.
Conclusiones:
La acalasia se asocia a una disminución de la calidad de vida y a un aumento significativo de la mortalidad. La mejoría de los síntomas es el parámetro clínico más relevante para definir el éxito del tratamiento quirúrgico, sin embargo, este objetivo no se consigue en una parte importante de los pacientes con acalasia, ya que ningún tratamiento actual proporciona una cura definitiva y la eficacia general se deteriora con el tiempo.
The Effect Of Health, Education, Capital, Technology, Inflation, And Gross Of Regional Domestic Products On Poverty Level In North Maluku Province
Authors: Tommy Kuncara  , Didin Mukodim  , Waseso Segoro
Published: July 2021

Poverty is a social problem that occurs due to various factors including economic, social and cultural. This problem continues to occur in almost every developing country and the same case is also found in countries that are already advanced in their economic systems. Currently in Indonesia, especially the problem of poverty is still concentrated in the eastern part of Indonesia, this is caused by uneven human development in terms of education, employment, infrastructure, and the economy. The purpose of this study is to analyze the effect of labor on the poverty level, the effect of capital on the poverty level, the effect of inflation on the poverty level, and the effect of gross regional domestic product on the poverty level. The object of research is the Province North Maluku. The data used in this research is secondary data. The data analysis method uses a panel data regression model with an estimated random effect model and a fixed effect model. Then the analysis technique used is the determination of the panel data estimation model, the classical assumption test, and the significance test. The results of this study indicate that the variable life expectancy which represents overall health has no effect on the level of poor people in North Maluku Province. The variable of Old School Expectation which represents education in general affects the level of poor people in does not affect the poverty level in North Maluku Province. The variable average length of schooling represents education in general that affects the level of the poor in North Maluku Province. Capital is divided into Capital Expenditure variables and KUR represents Capital. Capital Expenditure as a whole has an effect on the poverty level has no effect on the poverty level in North Maluku Province. KUR as a whole does not affect the poverty level does not affect the poverty level in North Maluku Province. The technology variable that represents technology as a whole affects the poverty rate does not affect the poverty rate in North Maluku Province. Inflation variable is inflation as a whole does not affect the poverty level also in North Maluku Province. The Gross Regional Domestic Product (GRDP) variable represents the overall GRDP that affects the poverty level does not affect the poverty level in North Maluku Province.
Network Perspective In The Internationalization Of Indonesian SMEs In The Era Of Indutrial Revolution 4.0
Authors: Anni Yudiastuti  , F. Danardana Murwani  , Sudarmiatin  , Agus Hermawan
Published: July 2021

The level of globalization that goes hand in hand with the 4.0 industrial revolution demands the fighting power of companies both in large and small and medium scales to determine dynamic strategies in anticipating competition and expansion targets through international markets. SMEs in Indonesia as the spearhead and pillars of Indonesia's economic strength are also required to be able to improve their performance, especially in promoting their business on an international scale. Indonesian product SMEs for export competitiveness are mostly based on local wisdom-based products, therefore innovation is needed in developing products with local wisdom. Various obstacles faced by SMEs in managing their businesses, especially related to limitations in implementing production management activities, human resource management and marketing management. The solution to the various limitations that have become problems for SMEs in facing the internationalization process is to establish a network that involves various stakeholders. The networkQuality and integrated with the support of government programs will be able to support the competence and capabilities of SMEs in facing the internationalization process in the industrial revolution 4.0. This study examines the role of networks in enhancing the internationalization strategy of Indonesian SMEs.
Potential Drug Interactions Of Oral Antidiabetic In Prescriptions Of Type 2 Diabetes Mellitus Patients At Kumpulan Pane Hospital
Authors: Nana Nurhasanah Rumanda , Khairunnisa  , Urip Harahap
Published: July 2021

Diabetes Mellitus is a disease that can cause complications of other diseases so that the treatment to be given becomes more and this has the potential for interactions between drugs that can affect the physiological condition of the patient.  The aim of this study is to  analyze the potential of oral antidiabetic interactions on prescription at Kumpulan Pane Hospital.  Analysis of potential oral antidiabetic interactions on a prescription using quantitative research methods is retrospective descriptive. Prescriptions used are inpatient and outpatient prescriptions for the period January-December 2020 that get oral antidiabetics. Analyze data using Medscape and Drugs.com sites.  Based on analysis of 9.818 prescription sheets of diabetes mellitus patients, there were found 6.454 (65.73%) prescription of potential oral antidiabetic interactions. Potential interaction of an oral antidiabetic group of 10.759 (91.45%) drug, the pattern of interaction mechanisms most often is pharmacodynamic 73.25%. The most common type of oral antidiabetic drugs that have potential interactions is the biguanide group (metformin) 36.76%. The severity of the most frequent interactions was 92.21%.  The conclusion of the potential interactions  oral antidiabetic are still found in prescriptions that is 65.73% at Kumpulan Pane Hospital.

Keyword:  Potential Drug Interactions, Oral Antidiabetics, Prescription
The Influence Of Hit Distances And Dimensions Candlenut For Perfomance Improvement On Breaking Machine Candlenut
Authors: Anggara Mietra , Ardiansyah
Published: July 2021

Candlenut is one of the crops that grow in Indonesia. In Batu Dulang village Batulante sub-district Sumbawa there are candlenut entrepreneurs whose process of breaking candlenut seeds is still manual, person  can break 14 – 17 kg/day of candlenut. This reseach was aimed to examine the influence of distance and dimension of candlenut and to increase the performance machines at nutcracker . This reseach was conducted in November to December 2020  at workshop engineering study program, faculty of technique, Sumbawa university. The method used was a  case study striking distance (18 mm, 20 mm, 22 mm) small Candlenut dimensions, 18mm to 25 mm, large Candlenut dimension 26 mm to 35 mm, with three levels of treatment and each treatment combination was striking distance of  dimensions three time. The parameters of this study ware the parcentage of the whole core, parcentage of split halves, parcentage of core broken and parcentage of seeds escaped. The results of this study indicate that the treatment striking distance of dimensions has a significant effect on percentage of crushed core and percentage of seeds escaped. The highest of the intact core wa found at a small Candlenut dimensions striking distance 18 mm 60%, parcentage of split halves of 18 mm 20%, parcentage of  20 mm 10% core broken  and parcentage of  22 mm  60% seeds escaped. The highest of the intact core wa found at a larges Candlenut dimensions striking distance 20 mm 53,33% parcentage of split halves of 18 mm yaitu 30% parcentage of  18 mm 10%,core broken  and parcentage of  22 mm  60% seeds escaped.
Analysis Of The Application Of Recording Methods And Assessment Of Inventories In Accordance With Psak No. 14 At Andrew Smith Urban Lifestyle Supermall Karawaci
Authors: Dwi Kartinah  , Tommy Kuncara
Published: July 2021

Inventory is one of the assets that has an important role for the activities of a company. The problem that often occurs in inventory is when recording and evaluating inventory. Generally, recording is not detailed or even manually, thus making inventory reports unclear and not good. This makes the researcher want to compare the inventory treatment of Andrew Smith's Urban Lifestyle Supermall Karawaci store with PSAK No. 14.This research was conducted using a descriptive method with quantitative and qualitative data sourced from primary and secondary data. The data obtained are then processed, analyzed, and interpreted to determine the comparison with PSAK No. 14. Andrew Smith Urban Lifestyle is a manufacturing company engaged in the men's clothing industry such as: jackets, shirts, pants, chinos, sweaters, blazers, ties, accessories, shoes, and sneakers. The result of this research is that the store's inventory recording has not used a method that is in accordance with PSAK No. 14, there is only a partial recording referring to the perpetual method, namely when there is an entry and exit of goods that is directly recorded in a computerized manner. While the inventory valuation is also not in accordance with PSAK no. 14 because it does not use the FIFO method. Using the FIFO method will result in a clearer and better inventory valuation.
The Influence Of Financial Flexibility, Managerial Ownership, Firm Size On Capital Strukture, And Firm Value On Infrastructure, Utility And Transportation Companies
Authors: Asrul Jaya  , Djabir Hamzah  , Maat Pono  , Idayanti Nursyamsi
Published: July 2021

This study aims to analyze the effect of financial flexibility, managerial ownership, and firm size on firm value with capital structure as an intervening variable for infrastructure, utility, and transportation companies. This research was a quantitative study. The data used were secondary data in the form financial statements of infrastructure, utility and transportation companies listed in the Indonesia Stock Exchange during the period 2015-2019. The sample used was a purposive sampling technique consisting of 30 companies infrastructure, utility and transportation. The data were analyzed using path analysis supported by SmartPLS 3.3 software. The results show that financial flexibility has no significant negative effect on the capital structure; managerial ownership has a significant negative effect on the capital structure; firm size has a significant positive effect on the capital structure; financial flexibility has a significant negative effect on firm value; managerial ownership has no significant positive effect on firm value; firm size has no significant positive effect on firm value; capital structure has a significant positive effect on firm value; financial flexibility had no significant effect on firm value through capital structure; managerial ownership has a significant effect on firm value through capital structure; firm size has a significant effect on firm value through capital structure.
KOMUNIKASI DAKWAH KOLABORATIF PEMERINTAH DESA MELALUI KEBIJAKAN PUBLIK
Authors: Huda Miftahul , Nuha Muhammad Ulin , Mashfufah Dewi
Published: July 2021

Margoyoso Jepara village is a village that has socio-religious problems as part of the negative impact of the times. Under these conditions, the Village Government carried out collaborative da'wah communication in overcoming these problems. This type of research is qualitative with field research methods. In this study, data collection techniques through interviews, observation, and documentation. Data analysis techniques used in the form of inductive and descriptive narrative. The results of this study explain that collaborative da'wah in the Margoyoso Village Government is influenced by the existence of a village autonomy system, where the Village Government can manage and regulate its own government area according to the characteristics and styles of each. The emergence of collaborative da'wah policies is motivated by social and political religious problems. The message of Da'wah communication in the form of congregational dawn prayers, turning off the television after sunset, let's recite the Koran, and compulsory madrasah diniyah was formed through a deliberation process by the Village Government, community leaders, religious leaders, socio-religious organizations, and related stakeholders. Collaborative da'wah policy has benefits as a means to strengthen friendship with residents, a means of socialization and village information, as well as a means to improve the quality of religion and community education.
Protocolos de bioseguridad para la atención odontológica durante la pandemia COVID-19 en países de América Latina
Authors: Muñoz Huamán Deyvi Jhoan , Fernández Bravo Freddy Humberto , Chiroque Pérez Tania Elizabeth , Román Campos Samuel Amado Natanael , Villalobos Veliz Lucia del Carmen , Valenzuela Ramos Marisel Roxana
Published: July 2021

Los protocolos de bioseguridad son importantes para la protección del personal de salud. En odontología estas medidas ayudarán a cuidar la salud de médico y paciente. Sin embargo, en América Latina el riesgo de contagio por la pandemia, ha obligado a adoptar medidas más drásticas que deben respetarse cuidadosamente. Describir los protocolos de bioseguridad recomendados por los Ministerios de Salud en los países de Latinoamérica para la atención odontológica durante la pandemia. Se realizó una búsqueda detenida sobre protocolos de bioseguridad; publicadas con una antigüedad de 1 año y medio en la base de datos de cada Ministerio de Salud y en Google. Los artículos de investigación, la información se hallaba en el idioma español, inglés, francés y portugués, se utilizó el método de comparación para ejecutar la revisión. Fueron encontrados 52 protocolos concernientes a la atención odontológica y aplicando criterios de comparación se hallaron 17. Los protocolos que se identificaron coinciden en su mayoría con los recomendados por la OMS, protocolos clínicos, sustancias a usarse y dispositivos utilizados, asimismo en algunos países no se encontraron ningún tipo de protocolo, o simplemente se rigen a las normas generales impuestas a los servicios de salud.
A IMPORTÂNCIA DOS INSTITUTOS FEDERAIS DE EDUCAÇÃO, CIÊNCIA E TECNOLOGIA NO DESENVOLVIMENTO SOCIOECONÔMICO DOS MUNICÍPIOS DO ESTADO DE SÃO PAULO
Authors: Mello de Andrade Adriano , Baade Accarino Yunes Rocha Augusto , Carvalho Santos Breno , Larrúbia Marques Fernanda , Mariano Neres Marcel
Published: July 2021

Com o propósito de estudar o impacto das transformações socioeconômicas trazidas pela criação e expansão dos Institutos Federais de Educação Profissional, Científica e Tecnológica, este artigo tem por objetivo estabelecer uma análise acerca das mudanças que a presença das escolas técnicas federais tem provocado nos municípios do estado de São Paulo em termos de ampliação dos níveis de renda per capita da população. A metodologia adotada na pesquisa foi quantitativa e empírica, baseada na realização de um teste de diferença de médias, de um teste de hipóteses e de uma análise de regressão que permite a quantificação e inferência das variáveis utilizadas e a posterior análise dos dados correlatos. Os resultados observados dizem respeito à constatação de que a presença de Institutos Federais não está diretamente associada às alterações nos patamares de PIB per capita da população. Já os resultados concernentes à variável de controle de renda formal são significantes e fornecem evidências de que a sua presença em alguns municípios do estado de São Paulo está correlacionada às mudanças nos níveis de renda formal média da população local.