bluuebunny/crossref_metadata_2025 huggingface dataset:
The Efficacy of Axillary Reverse Mapping for the Prevention of Lymphedema
Authors: Ruffino Amanda E. , Madera Joshua D. , Dearborn Makayla M. , Frank Katie , Oxenberg Jacqueline C.
Published: August 2023

Background

Lymphedema (LE) is the most notable complication of axillary surgery. The axillary reverse mapping (ARM) technique was created to decrease LE. This study aims to evaluate a single surgeon’s experience with ARM in patients undergoing sentinel lymph node biopsy (SLNB) or axillary lymph node dissection (ALND) for breast cancer.

Methods

We retrospectively analyzed patients who underwent SLNB or ALND. Tumor characteristics and treatments received were evaluated. Surgical intervention and use of ARM were compared to assess LE rates. A subgroup analysis was also performed of patients who underwent NAC.

Results

LE was initially reported in 7.1% (n = 10) of patients; 3.3% (n = 4) with SLNB and 35% (n = 6) with ALND. At initial follow-up, LE was reported 16.4% more often in patients who underwent ALND with no ARM, and 38.8% more often in patients who underwent ALND plus ARM. An increased risk of LE was found in patients treated with ALND (OR = 16.0, P < .001). All patients who underwent ARM were 12.75% more likely to develop LE if they received NAC ( P < .05). Patients in the ALND group who also received NAC were more likely to undergo ARM as compared with patients in the SLNB group ( P < .01).

Discussion

Our study showed that ARM failed to decrease the incidence of LE. Until better surgical outcomes are shown for the prevention of LE using ARM, other approaches should be utilized. However, larger prospective studies are needed to evaluate ARM.
Fear of Positive Evaluation and Loneliness: Mediating Role of Social Anxiety and Suppression
Authors: Akkuş Koray
Published: August 2023

Loneliness is a commonly observed problem that is associated with several mental and physical health outcomes. Although research shows that fear of negative evaluation is related to loneliness, no study has examined the role of fear of positive evaluation (FPE) on loneliness. This study investigated the mediator role of social anxiety and suppression in the relationship between FPE and loneliness using an undergraduate sample ( N = 467). The results show that FPE is positively associated with loneliness and that this relationship is mediated by social anxiety and suppression. This study highlights the importance of the FPE in understanding loneliness and can guide intervention programs for loneliness.
Lightweight and Alternative Backfills for Highway Applications: State-of-the-Art Practice in the U.S.A.
Authors: Qamhia Issam I. A. , Tutumluer Erol , Nicks Jennifer E. , Adams Michael T. , Khan Mohammad S.
Published: August 2023

The use of lightweight and alternative materials in geotechnical applications may be advantageous when compared with more conventional structural backfills. This paper focuses on using seven lightweight and alternative backfill materials in highway applications: controlled low-strength materials (CLSM); expanded shale, clay, and slate (ESCS); foamed glass aggregates (FGA); lightweight cellular concrete (LCC); polystyrene geofoams; recycled glass aggregates; and tire-derived aggregates (TDA). The current knowledge and the state-of-the-art practice for using these materials in highway geotechnical applications of interest, that is, retaining walls, bridge abutments, pipes/culverts, embankments, and slope stabilization, were evaluated. The paper first introduces the materials, including the unit weight ranges for each lightweight and alternative fill material, and their applications. Then, the key aspects and advantages of each material for highway geotechnical applications are listed and evaluated. Further, for each material, the physical, chemical, and mechanical material properties are discussed, as well as the design requirements and guidelines, construction and placement guidelines, and the environmental considerations. Finally, the technology-ready aspects of each material studied with regard to its application to highway geotechnical problems, and the identified barriers to the deployment of each one were summarized and discussed. Based on the current knowledge, some lightweight and alternative materials (e.g., ESCS, CLSM, TDA) have been more widely used in the U.S.A. for geotechnical applications, whereas others are still emerging technologies. Further, certain materials (e.g., LCC, TDA, geofoam) have well-developed design guidelines, whereas others (e.g., CLSM, FGA) require more research.
The lasting significance of viruses: COVID-19, historical moments and social transformations
Authors: Wagner Peter
Published: August 2023

Three years after the onset of the COVID-19 pandemic, this article reviews the question of the lasting socio-political significance of the appearance of the virus, much and controversially debated at the beginning. We can see now – maybe rather unsurprisingly – that the expectations of rapid pandemic-related social change, whether positive or negative, were widely exaggerated. Rather, the pandemic has now entered into an interpretation of the global socio-political constellation as marked by a sequence of crises, including the financial crisis of 2008 and after, climate change, COVID-19 and now the Russian invasion of Ukraine. Thus, the task can be rephrased as asking whether these crises push into a similar direction, namely a re-appreciation of authoritative collective action against the laissez-faire view of extending global commerce and communication and, if so, what the consequences of such a re-appreciation may be.
Health Outcomes of Social Pension Expansion: A Quasi-Experiment Among Older Adults in Hong Kong
Authors: Zhu Alex Yue Feng , Chou Kee Lee
Published: August 2023

A social pension, regarded as a reliable source of income, has the potential to significantly influence the overall wellbeing of vulnerable older adults. This study aimed to extend the understanding of the effects of social pension expansion beyond its economic impacts to encompass recipients’ health status. Using three-wave data from a representative sample of older adults, we employed a quasi-experimental assessment model to evaluate the impact of a recent social pension expansion in Hong Kong on health-related consumption and health outcomes among older adults. The results of the triple difference estimations revealed that an increased social pension significantly enhanced older people’s engagement in entertainment activities, utilization of healthcare services, and expenditures on preventive health products. Furthermore, the increased social pension was found to have a significant positive effect on mitigating poor self-rated health and poor sleep quality. However, it did not have a significant impact on the prevalence of depression. These findings suggest that social pension expansion should be coordinated with other policy initiatives to comprehensively improve the physical and mental health of older adults.
Parametric dependence and elementary modelling for compressor disc cavity heat transfer
Authors: Sun Zixiang , Chew John , Gao Feng , Bristot Andrea , Williams Jake
Published: August 2023

A wall-modelled large-eddy simulation (WMLES) method previously validated against laboratory experiments is applied to a real engine disc cavity geometry with surface and air temperatures representative of maximum power conditions. An appropriate set of independent nondimensional parameters describing the problem is defined and the sensitivities to these parameters are investigated by independently varying each parameter in the WMLES. Effects of a change in disc temperature distribution and a reduction in radius of the downstream disc are also investigated. The flow and heat transfer mechanisms predicted are very similar to those found for the research rig configuration although rotating cavity flow structures with two or more lobes are found for the engine geometry rather than the single-lobed structures shown in previous work. The simulations are compared with an elementary model giving further insight into scaling of the flow and heat transfer with operating conditions. The model assumes a well-mixed core flow in the cavity with constant rothalpy, relates shroud heat transfer to that of natural convection under gravity for high Rayleigh number, and relates disc heat transfer to conduction across unsteady Ekman layers. An energy balance for the cavity is used to obtain an effective mass flow exchange rate between the axial throughflow and the disc cavity to the disc and shroud heat transfer and core temperature. The model is considered to give a useful basis for engineering calculations involving correlation and extrapolation of WMLES and experimental results.
Evaluation of canine and feline leukocyte differential counts obtained with the scil vCell 5 compared to the Advia 2120 hematology analyzer and a manual method
Authors: Zelmer Kim-Lina Charlotte , Moritz Andreas , Bauer Natali
Published: August 2023

The vCell 5 (scil Animal Care), a point-of-care hematology analyzer (POCA), was recently introduced to veterinary laboratories. This laser- and impedance-based analyzer is capable of providing a CBC with 5-part WBC differential count (Diff) along with WBC cytograms and flags serving as interpretation aids for numerical results. We compared the scil POCA-Diff to reference methods (i.e., manual differential count, Advia 2120 hematology analyzer [Siemens]) for canine and feline blood samples and considered WBC cytograms and flags. Total observed error (TEo), calculated from CV and bias%, was compared to total allowable error (TEa). Data were analyzed before and after a review process (exclusion of flagged and samples with invalid cytograms). For both species, correlation was good-to-excellent ( rs = 0.81–0.97) between both analyzers for all variables, except for feline monocytes ( rs = 0.21–0.63) and canine monocyte% ( rs = 0.50). Smallest biases were seen for neutrophils (dog: −5.7 to 0.8%; cat: 1.5–9.4%) with both reference methods. Quality requirements (TEo < TEa) were fulfilled for canine and feline neutrophils (TEo = 5.3–10.6%, TEa = 15%) and eosinophils (TEo = 67.1–83%, TEa = (90)–50%) considering at least one reference method. Our review process led to mildly higher rs-values for most variables. Although not completely satisfactory, the scil POCA provides reliable results in compliance with ASVCP quality goals for canine and feline neutrophils and eosinophils. Analyzer flag and cytogram analysis served as useful tools for QA, indicating the necessity for manual review of blood smears, and contributed to improvement of scil POCA performance.
End-of-Life Symptoms in Adult Patients With Stroke in the Last Two Years of Life: An Integrative Review
Authors: Ramsburg Hanna , Moriarty Helene J. , MacKenzie Greenle Meredith
Published: August 2023

Background

Stroke is a leading cause of death globally, yet End-of-Life (EOL) symptoms and their management in these patients are not well understood.

Purpose

This integrative review aims to critique and synthesize research on EOL symptoms and symptom management in adult patients with stroke in the last 2 years of life in all settings.

Methods

The Whittemore and Knafl integrative review methodology guided this review. PubMed, CINAHL, Scopus, Web of Science, and Google Scholar were used for the literature search. Included studies were published in English and quantitatively examined symptoms and symptom management. Quality appraisal was guided by the Effective Public Health Practice Project (EPHPP) assessment tool.

Results

Seven studies, all rated weak, were included in this review. A total of 2175 adult patients from six countries were represented. Results are classified into three main themes: EOL symptom experience, symptom assessment, and symptom management. Commonly reported EOL symptoms among adults with stroke include both stroke-specific (dysphagia, dysarthria) and non-specific symptoms (pain, dyspnea, constipation, and psychological distress). However, communication difficulties and the infrequent use of standardized tools for symptom assessment limit what is known about the EOL symptom experience. Although the relief of pain is generally well-documented, dyspnea and anxiety are much more poorly controlled.

Conclusions

There is a need for better assessment and management of EOL symptoms in patients with stroke. Established palliative and EOL care guidelines need to be incorporated into clinical practice to ensure access to high-quality care.
Geographies of imagination: why decolonizing Polish children’s classics matters
Authors: Balogun Bolaji , Ohia-Nowak Margaret
Published: August 2023

This article examines the iconography of blackness in the book covers of early Polish children’s literature. In doing so, it draws attention to textual practices that consciously or unconsciously reproduce the long-existing Eurocentric colonial/racial imaginaries of Africa and its people. This literature often depicts the inferiority of illustrated Black bodies, whilst highlighting the superiority of whiteness and Europeanness, as part of the global colonial/racial order. Such cultural productions, which contribute to the reproduction and dissemination of contemporary racism, are intertwined with the everyday experiences of people of colour in Poland.
Entertainment or Engagement? An Examination of Transportation and Gender in Virtual Reality
Authors: Meadows Charles W.
Published: August 2023

Virtual reality (VR) promises a new world of opportunities for public health practitioners including the potential for developing more engaging health narratives. However, a limited amount of research has been conducted on the effectiveness of VR as a form of narrative persuasion. Past research has noted that mental transportation plays a role in the persuasiveness of narratives. Through an experimental design, this study sought to examine transportation in a VR simulation and determine if demographic characteristics impact an individual’s ability to be transported into a narrative. Transportation did occur in the VR simulation; however, it was not more significant than the 2D simulation. Additionally, the results revealed gender differences in transportation scores, but the social norm message did not impact the behavioral intention to refrain from texting while driving in the future. These findings highlight the potential complexities of implementing VR technologies in health communication campaigns.
Joint Efforts: Can We Succeed? Stimulating Organizational Citizenship Behaviors Through a Psychosocial Safety Climate
Authors: Yang Yang , Yan Rui , Gao Yuting , Feng Feng , Meng Yan
Published: August 2023

Serious emergencies exacerbate the uncertainty, complexity, and ambiguity of the external environment, creating survival challenges for organizations and employees. During emergencies, it becomes more difficult for organizations to leverage organizational citizenship behaviors (OCBs) from their employees to survive existential crises. From the perspective of resource exchange and investment, we explore the ways that organizations can collaboratively overcome difficulties by motivating their employees to engage in OCBs. Our findings show that (1) a psychosocial safety climate (PSC) that is adopted by an organization can effectively stimulate employee OCBs, which are of greater help to organizations than to coworkers, (2) resilience may be a psychological resource that explains the stimulating effect of a PSC on OCBs, and (3) employee trait gratitude enhances the role of resilience in mediating the relationship between a PSC and helping behaviors (but not civic virtue behaviors). Our findings not only reveal the mechanisms by which organizations can stimulate employee OCBs when the two face survival challenges during serious emergencies but also provide a recommendation for managers to focus on employee mental health and resilience during crises.
SME Internationalization as a Puzzle of Cultural and Bilateral Distances: Using the Eisenhardt Approach
Authors: Buganova Alima , Banerji Diptiman , Buganova Svetlana
Published: August 2023

Small and medium-sized enterprises (SMEs) have recently been discovered to function as catalysts for globalization. However, despite the increasing interest in the internationalization of SMEs, doing business in another country offers its own unique set of challenges that must be overcome if an SME’s international venture is to be successful. For sectors where operational efficiency is necessary and there are added pressures due to cultural differences in consumer behaviour (e.g., fast-food chains), managing the operations process is essential for ensuring success and growth. Furthermore, the export of the conventional business model becomes complicated because of the significant variations in brand localization requirements across nations, which force businesses to make significant changes to cater to local client preferences. Given this scenario, how can an SME identify and adjust the critical barriers towards deciding and acting on foreign market entry and exit?

To answer this question, we looked for a theoretical sample (case) of a business that successfully entered and operated in some markets and exited from others within the same period. In this investigation, we examine the Russian pizza company Dodo Pizza’s exodus from China and the UK as compared to their successful operations in Kazakhstan using Eisenhardt’s comparative case methodology. We use each country’s operations as a case in this research and apply Eisenhardt’s comparative case methodology to identify and theorize the factors of national context essential to the organization’s actions and outcomes in a given country.
Impact of signs and symptoms on the prognosis of patients with HFmrEF
Authors: Liu Zhican , Zhu Yunlong , Zhang Lingling , Wu Mingxin , Huang Haobo , Peng Ke , Zhao Wenjiao , Chen Sihao , Peng Xin , Li Na , Zhang Hui , Zhou Yuying , Chen Yongliang , Xiao Sha , Yi Liqing , Fan Jie , Zeng Jianping
Published: August 2023

Background

Worsening of heart failure (HF) symptoms is the leading cause of medical contact and hospitalization of patients with mildly reduced ejection fraction (HFmrEF). The prognostic value of signs and symptoms for patients with HFmrEF is currently unclear. This study investigated the prognostic impact of signs and symptoms in HFmrEF patients.

Methods

A Cox proportional risk regression model analyzed the relationship between the number of signs/symptoms and outcomes in 1691 hospitalized HFmrEF patients. Ten significant signs and symptoms were included. Patients were divided into three groups (A: ≤2, B: 3–5, C: ≥6 signs/symptoms). Stratified analysis on male and female patients was performed. The primary endpoint was all-cause mortality, and the secondary outcome was a composite of cardiovascular death and heart failure readmission (CV events) post-discharge.

Results

After a median follow-up of 33 months, all-cause mortality occurred in 457 patients and CV events occurred in 977 patients. Incidence of all-cause mortality was 20.7%, 32.3%* and 49.4%*† in group A, B and C of male patients, (*P < 0.05 vs. A, †P < 0.05 vs. B) and 18.8%, 33.6% and 55.8%* in group A, B and C of female patients. Incidence of CV events was 64.8%, 70.1%* and 87.5%* in group A, B and C of male patients, 61.9%, 75.3%, and 86.1%* in group A, B and C of female patients. Multivariate Cox regression showed older age, renal insufficiency, higher number of signs and symptoms (≥ 3, hazard ratio [HR] 1.317, 95% confidence interval [CI] 1.070–1.621, P = 0.009; ≥6, HR 1.982, 95% CI 1.402–2.801, P < 0.001), myocardial infarction, stroke, faster heart rate on admission, and diabetes were independently associated with all-cause mortality(all P < 0.05). Similarly, higher number of signs and symptoms (≥ 3, HR 1.271, 95% CI 1.119–1.443, P < 0.001; ≥6, HR 1.955, 95% CI 1.524–2.508, P < 0.001), older age, renal insufficiency, atrial fibrillation, and diabetes were independently associated with cardiovascular events (all P < 0.05).

Conclusions

Higher number of symptoms and signs is associated with increased risk of all-cause mortality and CV events in HFmrEF patients. Our results highlight the prognostic importance of careful inquiry on HF symptoms and related physical examination in HFmrEF patients.
Comparative study on clinicopathological features and prognosis of IgA vasculitis nephritis and IgA nephropathy in children
Authors: Lv Yan , Fu Rui , Peng Xiao-Jie , Wang Ying , Yin Ting-Ting , Deng Yan-Qing
Published: August 2023

Background

IgA vasculitis nephritis (IgAVN) and IgA nephropathy (IgAN) share several clinical and pathological characteristics, though distinctions also exist. Their interrelation, however, remains undefined. This study investigates the clinicopathological divergences and prognostic disparities in pediatric patients with IgAVN and IgAN.

Methods

Our study encompasses 809 pediatric patients with IgAVN and 236 with IgAN, all of whom underwent kidney biopsy. We utilized the Semiquantitative Classification (SQC) scoring system to juxtapose the pathologies of the two conditions, and performed a COX regression analysis to examine factors influencing their prognoses.

Results

Both patient groups demonstrated a predominance of males. A seasonality was observed, with a higher incidence of IgAN in the summer, and IgAVN in the fall (P < 0.0001). Patients with IgAN exhibited more severe tubulointerstitial injury, higher chronicity index, and total biopsy scores compared to those with IgAVN (P < 0.0001). Mesangial deposition intensity of complement C3, and the rate of pure IgA deposition, were found to be greater in patients with IgAVN compared to those with IgAN (P < 0.0001). The intensity of IgA deposition was also significantly higher in IgAVN patients (P = 0.003). IgAVN demonstrated a superior prognosis, with a higher rate of kidney remission (P < 0.0001). COX regression analysis indicated that interstitial fibrosis, as identified in the SQC pathology system, was associated with the prognosis of both conditions. Furthermore, the findings suggest that IgA deposition levels (IgA +  + and IgA +  + +) could potentially influence the prognosis of IgAVN.

Conclusions

Compared to IgAVN, IgAN manifests more severely with regard to renal impairment, interstitial damage, and prognosis. The disparities in immune complex deposition levels and locations within the kidneys support the hypothesis of IgAVN and IgAN as distinct diseases. Interstitial fibrosis may serve as a key pathological indicator within the SQC system associated with kidney prognosis in children with IgAVN and IgAN. The degree of IgA deposition could also be linked with the prognosis of IgAVN.
The Pathways study: a cohort study of new food-aid users in rural, semi urban, and urban areas of Quebec, Canada
Authors: Roncarolo Federico , Mercille Geneviève , Riva Mylene , Pérez Elsury , Blanchet Rosanne , Carabali Mabel , Sylvestre Marie-Pierre , Potvin Louise
Published: August 2023

Background

While considerable research has been conducted on household food insecurity (HFI), little research has examined the effects of food donation programs on users’ living conditions. The Pathways study was established to investigate the long-term effects of food donation programs on food insecurity as well as other critical outcomes, such as diet, health, and social support. Herein, we describe the design of the Pathways Study and the participants’ characteristics at baseline.

Methods

The Pathways study is a prospective cohort study of 1001 food-aid users in Quebec (Canada). We recruited newly registered users of food donation programs from 106 community-based food-aid organizations that partnered with the study. Baseline data were collected through face-to-face interviews from September 2018 to January 2020, with planned follow-up interviews at 12 and 24 months after enrollment. Household food insecurity, diet, food competencies, food shopping behaviors, perceived food environment, health status, social support and isolation, sociodemographic characteristics, housing conditions, negative life events, and the impacts of COVID-19 were assessed with validated questionnaires.

Results

The cohort included 1001 participants living in rural (n = 181), semi-urban (n = 250), and urban areas (n = 570). Overall, household food insecurity was reported as severe among 46.2% and moderate in 36.9% of participants. Severe household food insecurity was more prevalent in rural (51.4%) and urban (47.8%) areas compared to semi-urban (39%) areas. Overall, 76.1% of participants reported an annual income below C$20,000. Half (52%) had low education levels (high school or lower), 22.0% lived in single-parent households, and 52.1% lived alone. Most (62.9%) experienced at least one major financial crisis in the preceding year.

Conclusions

Results show that newly registered users of food donation programs often have low-income and severe food insecurity, with major differences across geographical locations. The Pathways study is the first study designed to follow, over a 2-year period, a cohort of newly registered users of food donation programs and to quantify their trajectories of service use. Findings from the Pathways study might help adapt the community response to the strategies used by food-insecure households to feed themselves.
Development and validation of the Socioeconomic Status Composite Scale (SES-C)
Authors: Sacre Hala , Haddad Chadia , Hajj Aline , Zeenny Rony M. , Akel Marwan , Salameh Pascale
Published: August 2023

Background

Socioeconomic status (SES) is a critical multifactorial determinant of health and plays a significant role in shaping an individual’s health outcomes. While a composite scale has been proposed to measure SES in children, to our knowledge, limited composite scales were developed for adults in different contexts, highlighting the need for a comprehensive and valid SES measure to elucidate the relationship between SES and health in this population.

Objective

This study aimed to develop and validate a composite scale that measures the socioeconomic status in Lebanon and assess its correlates in a socioeconomic crisis context.

Methods

An online study was carried out between October and November 2022 across all Lebanese regions. Snowball sampling was used to enroll 448 adults living in Lebanon through a questionnaire created on Google Forms and shared by WhatsApp to a first sample from all geographic areas.

Results

The developed composite scale (SES-C) was found to be reliable and valid. It was based on several aspects of socioeconomic status, i.e., participant education level, family head education level, perceived social class, not being in debt, not receiving financial help, crowding index, participant work status, family head work status, monthly household income, and financial well-being. Furthermore, high SES was significantly associated with married status, older age, alcohol consumption, the absence of chronic disease, easy access to healthcare, private insurance coverage, and the number of rooms in the house in the bivariate analysis. In the multivariable analysis, high SES was significantly associated with age (ORa-1.13; p = 0.011) and easy access to healthcare (ORa = 7.81; p = 0.001) and inversely associated with chronic disease (ORa = 0.17; p = 0.002). Similar results with lower magnitude were found for moderate SES.

Conclusion

The study successfully developed and validated a composite scale (SES-C) for measuring the socioeconomic status in Lebanon, taking into account the complexities of the Lebanese context. The scale was found to be reliable and valid, and its results showed significant correlations with various factors such as older age, lower risk of chronic disease, and easy access to healthcare.
Association between lean mass and adolescent idiopathic scoliosis: a meta-analysis
Authors: Xu Wei , Zang Jiajie , Wu Fan
Published: August 2023

Objective

The objective of this meta-analysis was to evaluate the association between lean mass and adolescent idiopathic scoliosis (AIS).

Methods

English databases CENTRAL (The Cochrane Library and the Cochrane Back Review Group Trials Register), MEDLINE, EMBASE, PubMed, Web of Science and Chinese databases CBM, CNKI, VIP, WANGFANG DATA were searched for the relevant case control studies and cross-sectional studies. Two authors selected studies and extracted data independently. Data analysis was performed by Stata15.0.

Results

Eight studies were included, with a total of 1771 cases of AIS and 6340 controls. AIS group had a lower lean mass compared to control group [MD =  − 1.95, 95% CI (− 2.96, − 0.93)]. In the subgroup analysis, female AIS patients had a lower lean mass than the control group [MD =  − 1.76, 95% CI (− 2.63, − 0.88)]. The mean difference of lean mass between AIS patients and control group in studies with adults [MD =  − 3.96, 95% CI (− 7.26, − 0.67)] is much greater than studies without adults [MD =  − 1.04, 95% CI (− 1.59, − 0.49)]. There was not statistically significant in European studies [MD =  − 2.10, 95% CI (− 4.35, 0.14)], but in Asian studies lean mass in AIS patients was lower than the control group [MD =  − 2.26, 95% CI (− 3.98, − 0.54)]. Study type, gender, age, and geography condition were thought to have no effect on the primary outcome of lean mass by subgroup analysis.

Conclusion

In the meta-analysis, AIS group had a lower lean mass compared to control group, which indicated that lean mass may be involved in the pathogenesis of AIS. But limited by the number of studies we included; the above conclusions need to be validated by more high-quality studies.
Antibacterial potential of biosynthesized silver nanoparticles using Nepeta sessilifolia Bunge and Salvia hydrangea DC. ex Benth. extracts from the natural habitats of Iran's Rangelands
Authors: Ghavam Mansureh
Published: August 2023

Background

Nowadays, the use of herbal extracts for the production of nanoparticles has attracted a lot of attention due to the fast reaction, economy, and compatibility with the environment. The aim of the present study is the biosynthesis of silver nanoparticles from the extracts of Nepeta sessilifolia Bunge and Salvia hydrangea DC. ex Benth. and their antibacterial activity was measured.

Methods

For this purpose, the flowering branch of N. sessilifolia and the flower of S. hydrangea were randomly collected from three places, respectively, from the rangelands of Aqdash Mountain and Biabe in Isfahan province, Iran in May 2021. After extracting aqueous extracts by hot method, silver nanoparticles were synthesized by the biological method. Green synthesized silver nanoparticles were analyzed by UV–Vis spectroscopy, XRD, FTIR, and FESEM-EDAX. The antibacterial effect was evaluated by diffusion method in agar and determination of minimum growth inhibitory and lethal concentration (MIC and MBC) by dilution method in liquid culture medium.

Results

Based on the results of UV–Vis spectroscopy, silver nanoparticles synthesized from N. sessilifolia and S. hydrangea had distinct absorption peaks at wavelengths of 407 to 424 nm and 414 to 415 nm, respectively. The crystalline nature of these synthetic silver nanoparticles was confirmed by XRD. FESEM analysis showed that the size of biosynthesized silver nanoparticles from N. sessilifolia and S. hydrangea extracts were 10–50 nm and 10–80 nm, respectively, and were cubic. The results of diffusion in agar showed that the largest diameter of the growth inhibition zone belonging to the synthetic silver nanoparticles from both extracts of N. sessilifolia (~ 26.00 mm) and S. hydrangea (~ 23.50 mm) was against Gram-positive bacteria Staphylococcus aureus. The most vigorous killing activity by synthetic silver nanoparticles from N. sessilifolia extract was against Klebsiella pneumoniae with a value of 250 μg/mL, two times stronger than rifampin.

Conclusion

Therefore, the studied extracts can be suitable options for fast and safe green synthesis of silver nanoparticles effective against some bacterial strains. These synthetic silver nanoparticles can be used as possible options and have strong potential for the production of natural antibiotics.
Impact of early postoperative blood glucose variability on serum endocan level in cardiac surgery patients: a sub study of the ENDOLUNG observational study
Authors: Chazal Etienne , Morin Lucas , Chocron Sidney , Lassalle Philippe , Pili-Floury Sebastien , Salomon du Mont Lucie , Ferreira David , Samain Emmanuel , Perrotti Andrea , Besch Guillaume
Published: August 2023

Background

Early postoperative glycemic variability is associated with worse outcome after cardiac surgery, but the underlying mechanisms remain unknown. This study aimed to describe the relationship between postoperative glycemic variability and endothelial function, as assessed by serum endocan level in cardiac surgery patients.

Methods

We performed a post hoc analysis of patients included in the single-center observational ENDOLUNG study. Adult patients who underwent planned isolated coronary artery bypass graft surgery were eligible. Postoperative glycemic variability was assessed by calculating the coefficient of variability (CV) of blood glucose measured within 24 (CV24) and 48 (CV48) hours after surgery. Serum endocan level was measured at 24 (Endocan24) and 48 (Endocan48) hours after surgery. Pearson’s correlation coefficient with 95% confidence interval (95% CI) was calculated between CV24 and Endocan24, and between CV48 and Endocan48.

Results

Data from 177 patients were analyzed. Median CV24 and CV48 were 18% (range 7 to 39%) and 20% (range 7 to 35%) respectively. Neither CV48 nor CV24 were significantly correlated to Endocan48 and Endocan24 respectively (r (95% CI) = 0.150 (0.001 to 0.290; and r (95% CI) = 0.080 (-0.070 to 0.220), respectively).

Conclusions

Early postoperative glycemic variability within 48 h after planned cardiac surgery does not appear to be correlated with postoperative serum endocan level.

Clinical trial registration number

NCT02542423.
What are the most common controversial clinical issues in fertility preservation? A content analysis of a collaborative professional online consultation group
Authors: Tsafrir Avi , BenHaroush Avi , Hyman Jordana , Karavani Gilad , Imbar Tal
Published: August 2023

Research question

Clinicians involved in fertility preservation (FP) are often required to make prompt and consequential decisions despite the absence of evidence-based data. We established a collaborative professional online consultation group for fertility preservation issues. We sought to determine the main controversial clinical issues in FP as raised by participants of this group.

Design

Content analysis of a dedicated community of practice interacting via a messaging application (WhatsApp) and a survey of group participants.

Results

Between January 2019 and July 2022, group members posed 39 clinical questions which were discussed and debated by the group. Common themes included management of oncofertility cases (33%), potential gonadotoxicity of various therapies (23%), fertility preservation in women and girls with premature ovarian insufficiency (POI) (18%), and technical aspects of ovarian tissue cryopreservation (10%). All but one query received prompt response (mean time for first response for 95% of queries 7.1 ± 9.0 min) from a mean of 5.4 ± 3.2 members.

An anonymous online survey of group members was conducted during August 2022 (n = 31, response rate 94%). The majority of respondents stated they gained knowledge and assistance in clinical decision making from participation in the discussion group (90% and 58% of respondents, respectively).

Conclusions

Management of clinical oncofertility cases, potential gonadotoxic effect of therapeutics and fertility preservation in women and girls with POI were the most common controversial issues in our fertility preservation community of practice. Intra-professional collaborative communication via a messaging application can aid in clinical management of fertility preservation and augment clinician’s knowledge.
Oblique lateral interbody fusion (OLIF) compared with unilateral biportal endoscopic lumbar interbody fusion (ULIF) for degenerative lumbar spondylolisthesis: a 2-year follow-up study
Authors: Cao Shuyan , Fan Bingjie , Song Xin , Wang Yi , Yin Wenzhe
Published: August 2023

Background

Oblique lumbar interbody fusion (OLIF) has been proven to be an effective method of indirect decompression for the treatment of Degenerative Lumbar Spondylolisthesis (DLS). However, its superiority over Unilateral biportal endoscopic Lumbar Interbody Fusion (ULIF) has not been reported yet. The current study aimed to compare the clinical and radiological outcomes of OLIF and ULIF in patients with DLS.

Methods

A total of 107 patients were included in this study, divided into two groups according to the surgical methods with 45 patients treated by OLIF combined with anterolateral single screwrod fixation, and 62 patients treated by ULIF. To compare the perioperative parameters (blood loss, operation time, and postop hospitalization) and clinical (the Visual Analog Scale (VAS) scores of the low back pain and leg pain and the Oswestry Disability Index (ODI)) and radiological (disk height (DH), lumbar lordosis (LL), segmental lordosis (SL), the cross-sectional area (CSA) of the spinal canal) results of the two surgical approaches to evaluate their efficacy.

Results

Compared with the ULIF group, the blood loss and operation time in the OLIF-AF group were significantly reduced, and the Postop hospitalization was comparable. The VAS scores in both groups were significantly improved compared to preop; however, the VAS score of low back pain in the OLIF-AF group was superior to that in ULIF group throughout the follow-up period (P < 0.05). The improvements in DH, LL, and Segmental angle were significantly lower in the ULIF group, and the expansion rate of CSA in the OLIF-AF group was superior to that in the ULIF group, but the difference was not statistically significant. The fusion rate in OLIF-AF group was significantly higher than that in ULIF group within 6 mo postop, and there was no significant difference at the last follow-up. The incidence of complications was comparable between the two groups, and there was no statistical difference.

Conclusions

Both OLIF-AF and ULIF achieved good short-term results in the treatment of DLS, and both surgical approaches are desirable. However, OLIF-AF has advantages over ULIF in terms of postoperative restoration of lumbar sagittal parameters and earlier intervertebral fusion. Long-term follow-up and larger clinical studies are needed to confirm this result.
Clinical value of combined serum CA125, NSE and 24-hour urine VMA for the prediction of recurrence in children with neuroblastoma
Authors: Li Jinmin , Qi Zilong , Chen Mo , Wang Jiachen , Liu Xiangyang
Published: August 2023

Background

In this study, we intend to retrospectively analyze the clinical data of postoperative neuroblastoma children, including the results of follow-up examinations and laboratory tests, to explore the clinical value of combined serum Carbohydrate antigen 125 (CA125), neuron-specific enolase (NSE) and 24-hour urine vanillylmandelic acid (VMA) levels at baseline for the prediction of recurrence in children with neuroblastoma.

Methods

265 children with neuroblastoma were successfully followed up, including 163 cases without recurrence (non-recurrence group) and 102 cases with recurrence (recurrence group). The levels of 24-hour urine VMA were determined using spectrophotometric methods. Additionally, the serum levels of CA125 and NSE were measured using electrochemiluminescence immunoassay.

Results

The serum CA125, NSE and 24-hour urine VMA levels were significantly higher in the recurrence group than in the non-recurrence group. It demonstrated a significant positive correlation between the levels of serum CA125, NSE, and 24-hour urine VMA in all children with neuroblastoma. All children in stage IV of neuroblastoma had the highest level of serum CA125, NSE and 24-hour urine VMA and vice versa. The combined CA125, NSE and VMA had significantly better sensitivity and specificity than an individual marker.

Conclusions

Combined serum CA125, NSE and 24-hour urine VMA had the potential to predict neuroblastoma recurrence more effectively.
Occurrence of Thelazia callipaeda and its vector Phortica variegata in Austria and South Tyrol, Italy, and a global comparison by phylogenetic network analysis
Authors: Unterköfler Maria Sophia , Dengg Patrick , Niederbacher Miriam , Lindorfer Sarah , Eberle Antonia , Huck Alexandra , Staufer Katalina , Zittra Carina , Wortha Licha Natalia , Hodžić Adnan , Duscher Georg Gerhard , Harl Josef , Schlüsslmayr Gerhard , Bezerra-Santos Marcos Antonio , Otranto Domenico , Silbermayr Katja , Fuehrer Hans-Peter
Published: August 2023

The zoonotic nematode Thelazia callipaeda infects the eyes of domestic and wild animals and uses canids as primary hosts. It was originally described in Asia, but in the last 20 years it has been reported in many European countries, where it is mainly transmitted by the drosophilid fruit fly Phortica variegata. We report the autochthonous occurrence of T. callipaeda and its vector P. variegata in Austria. Nematodes were collected from clinical cases and fruit flies were caught using traps, netting, and from the conjunctival sac of one dog. Fruit flies and nematodes were morphologically identified and a section of the mitochondrial cytochrome c oxidase subunit I gene (COI) was analysed. A DNA haplotype network was calculated to visualize the relation of the obtained COI sequences to published sequences. Additionally, Phortica spp. were screened for the presence of DNA of T. callipaeda by polymerase chain reaction. Thelazia callipaeda and P. variegata were identified in Burgenland, Lower Austria, and Styria. Thelazia callipaeda was also documented in Vienna and P. variegata in Upper Austria and South Tyrol, Italy. All T. callipaeda corresponded to haplotype 1. Twenty-two different haplotypes of P. variegata were identified in the fruit flies. One sequence was distinctly different from those of Phortica variegata and was more closely related to those of Phortica chi and Phortica okadai. Thelazia callipaeda could not be detected in any of the Phortica specimens.

Graphical Abstract
To predict the left ventricular endocardial scar tissue pattern using Radon descriptor-based machine learning
Authors: Singh Yashbir , Atalla Shadi , Mansoor Wathiq , Paul Rahul , Deepa Deepa
Published: August 2023

Objective

Scar tissue is an identified cause for the development of malignant ventricular arrhythmias in patients of myocardial infarction, which ultimately leads to cardiac death, a fatal outcome. We aim to evaluate the left ventricular endocardial Scar tissue pattern using Radon descriptor-based machine learning. We performed automated Left ventricle (LV) segmentation to find the LV endocardial wall, performed morphological operations, and marked the region of the scar tissue on the endocardial wall of LV. Motivated by a Radon descriptor-based machine learning approach; the patches of 17 patients from Computer tomography (CT) images of the heart were used and categorized into “endocardial Scar tissue” and “normal tissue” groups. The ten feature vectors are extracted from patches using Radon descriptors and fed into a traditional machine learning model.

Results

The decision tree has shown the best performance with 98.07% accuracy. This study is the first attempt to provide a Radon transform-based machine learning method to distinguish patterns between “endocardial Scar tissue” and “normal tissue” groups. Our proposed research method could be potentially used in advanced interventions.
Selective breeding can contribute to bovine tuberculosis control and eradication
Authors: Banos Georgios
Published: August 2023

Bovine tuberculosis (bTB) persists in many countries having a significant impact on public health and livestock industry finances. The incidence and prevalence of new cases in parts of the UK and elsewhere over the past decades warrant intensified efforts towards achieving Officially Tuberculosis Free (OTF) status in the respective regions. Genetic selection aiming to identify and remove inherently susceptible animals from breeding has been proposed as an additional measure in ongoing programmes towards controlling the disease. The presence of genetic variation among individual animals in their capacity to respond to Mycobacterium bovis exposure has been documented and heritability estimates of 0.06-0.18 have been reported. Despite their moderate magnitude, these estimates suggest that host resistance to bTB is amenable to improvement with selective breeding. Although relatively slow, genetic progress can be constant, cumulative and permanent, thereby complementing ongoing disease control measures. Importantly, mostly no antagonistic genetic correlations have been found between bTB resistance and other animal traits suggesting that carefully incorporating the former in breeding decisions should not adversely affect bovine productivity. Simulation studies have demonstrated the potential impact of genetic selection on reducing the probability of a breakdown to occur or the duration and severity of a breakdown that has already been declared. Furthermore, research on the bovine genome has identified multiple genomic markers and genes associated with bTB resistance. Nevertheless, the combined outcomes of these studies suggest that host resistance to bTB is a complex, polygenic trait, with no single gene alone explaining the inherent differences between resistant and susceptible animals. Such results support the development of accurate genomic breeding values that duly capture the collective effect of multiple genes to underpin selective breeding programmes. In addition to improving host resistance to bTB, scientists and practitioners have considered the possibility of reducing host infectivity. Ongoing studies have suggested the presence of genetic variation for infectivity and confirmed that bTB eradication would be accelerated if selective breeding considered both host resistance and infectivity traits. In conclusion, research activity on bTB genetics has generated knowledge and insights to support selective breeding as an additional measure towards controlling and eradicating the disease.
Prevalence of dementia, heart disease and stroke in community-dwelling adults in Canada, 2016–2021: opportunities for joint prevention
Authors: Singh Sarah S. , Zhong Shiran , Rogers Kem A. , Hachinski Vladimir C. , Frisbee Stephanie J.
Published: August 2023

Introduction

This aim of this study is to provide updated estimates on the prevalence of dementia, heart disease, and stroke in Canadian communities. Targeting all three conditions together, at the community level, may be key to disease prevention and health aging in the Canadian population.

Methods

Using nationwide health survey data, we calculated the age-standardized prevalence of self-reported dementia, heart disease and stroke in adults aged 18 years and over residing in Canadian communities from 2016 to 2021. Poisson regression models were used to detect statistically significant changes in the prevalence of all three conditions from 2016 to 2021.

Results

Less than 1% (~ 175,000 individuals) of adults residing in Canadian communities reported dementia, 5% (~ 1.5 million individuals) reported heart disease, and more than 1% (~ 370,000 individuals) reported stroke annually from 2016 to 2021. Overall, the age-standardized prevalence for stroke decreased minimally from 2016 to 2021 (p = 0.0004). Although the age-standardized prevalence of heart disease and dementia decreased from 2016 to 2018, subsequent increases in prevalence from 2018 to 2021 led to a lack of overall statistically significant changes from 2016 to 2021 (p = 0.10 for heart disease and p = 0.37 for dementia).

Conclusion

Recent increases in the prevalence of dementia, heart disease and stroke in Canadian communities threaten to reverse any gains in vascular disease prevention over the past six years. Findings reveal the urgent need for intensified prevention efforts that are community-based with a focus on joint reduction in the shared risk factors contributing to all three diseases.