bluuebunny/crossref_metadata_2025 huggingface dataset:
Operative versus nonoperative treatment in children with painful rigid flatfoot and talocalcaneal coalition. Results from a retrospective comparative study.
Authors: Gennaro Giovanni Luigi Di , Stallone Stefano , Olivotto Eleonora , Zarantonello Paola , Magnani Marina , Tavernini Tullia , Stilli Stefano , Trisolino giovanni
Published: December 2019

Background: The management of painful rigid flatfoot (RFF) with talocalcaneal coalition (TCC) is controversial. We aimed to compare operative and nonoperative treatment in children with RFF and TCC. Methods: We retrospectively reviewed medical records and radiographs of children with RFF and TTC treated between 2005 and 2015. The nonoperative treatment consisted of manipulation under anesthesia, cast immobilization and shoe insert after cast removal. The operative treatment consisted of combined TCC resection, graft interposition and subtalar arthroereisis. Results: Thirty-four Children (47 feet) in the nonoperative group and twenty-one children (34 feet) in the operative group were included. No differences were found between groups, concerning baseline characteristics. The mean age at treatment was 11.8 years (9-17). The mean follow-up averaged 6.6 (3-12) years. There were no complications in either groups. At the latest follow-up, the AOFAS-AHS improved in both groups, although the operative group showed significantly better improvement. The operative group reported also significantly better FADI score, after adjustment for follow-up and baseline variables. Conclusions: The operative treatment showed better results compared to the nonoperative treatment. Symptomatic RFF with TCC in children can be effectively treated in one step with resection, graft interposition and subtalar arthroereisis. Keywords: tarsal coalition, talocalcaneal; flatfoot; child; surgical treatment; manipulation under anesthesia; allograft; arthroereisis.
Constitutive Atg5 overexpression in mouse bone marrow endothelial progenitor cells improves experimental acute kidney injury
Authors: patschan daniel , Schwarze Katrin , Ritter Oliver , Patschan Susann , Müller Gerhard Anton
Published: December 2019

Background Endothelial Progenitor Cells have been shown as effective tool in experimental AKI. Several pharmacological strategies for improving EPC-mediated AKI protection were identified in recent years. Aim of the current study was to analyze consequences of constitutive Atg5 activation in murine EPCs, utilized for AKI therapy.Methods Ischemic AKI was induced in male C57/Bl6N mice. Cultured murine EPCs were systemically injected post-ischemia, either natively or after Atg5 transfection (Adenovirus-based approach). Mice were analyzed 48 hours and 6 weeks later.Results Both, native and transfected EPCs (EPCsAtg5) improved persisting kidney dysfunction at week 6, such effects were more pronounced after injecting EPCsAtg5. While matrix deposition and mesenchymal transdifferentiation of endothelial cells remained unaffected by cell therapy, EPCs, particularly EPCsAtg5 completely prevented the post-ischemic loss of peritubular capillaries. The cells finally augmented the augophagocytic flux in endothelial cells.Conclusions Constitutive Atg5 activation augments AKI-protective effects of murine EPCs. The exact clinical consequences need to be determined.
Cost of treatment and reduction achieved by chronic ulcer in diabetic patients - a comparison between hydrogel and human recombinant Epidermal Growth Factor
Authors: Deutsch Gabriela , Oliveira Bianca Campos de , Pessanha Fernanda Soares , Cassiano Keila Mara , Oliveira Beatriz Guitton Renaud Baptista de , Castilho Selma Rodrigues de
Published: December 2019

Background: The study provides results from a double-blind clinical trial of 25 patients with diabetic or venous chronic ulcers. The main focus was to evaluate the assessing cost of outpatient treatment with two technologies: 2% carboxymethylcellulose hydrogel or human recombinant Epidermal Growth Factor carbogel. Methods: Patients were randomly allocated to two ulcer treatment groups, human recombinant Epidermal Growth Factor carbogel treated (intervention group, n = 14), and 2% carboxymethylcellulose hydrogel (CMC) (control group, n = 11); both treated during 90 days. To calculate the costs of each patient's procedures, direct costs and human resources costs were measured in Brazilian currency and converted into US dollars. Statistical analysis of clinical data was performed based on intention to treat. For each treatment were analyzed the proportion of cases with wound reduction; cost benefit of the treatment given by the average value of each 1cm2 wound reduction; statistics on the cost of reducing each cm2 of wound for each patient presenting wound reduction. Results: In all evaluated periods, the proportion of cases with decreased lesion area was higher in the intervention group; It presented better cost-benefit ratio and lower average and median reduction cost for each reduced cm2 of the wound. Conclusion: Data suggested that growth factor therapy may be cost-effective and innovative complement to standard wound care.
Reevaluation of risk factors for time to subsequent events after first stroke occurrence using a new weighted all-cause effect measure
Authors: Ozga Ann-Kathrin , Rauch Bernhard , Palm Frederick , Urbanek Christian , Grau Armin , Becher Heiko , Rauch Geraldine
Published: December 2019

Background : Risk factors for stroke include atrial fibrillation, hypertension, diabetes mellitus, smoking, and high cholesterol. However, the role of these factors on subsequent cardiovascular events or death is less clear due to therapeutic measures. We therefore aim to get insights into the persistence of known risk factors on subsequent stroke or death one year after the first stroke and to illustrate how the new weighted all-cause hazard ratio can ease the interpretation of competing time-to-event endpoints with different clinical relevance. Methods : This study evaluates the one year follow-up of 470 first ever stroke cases identified in the area of Ludwigshafen, Germany, with 23 deaths and 34 subsequent stroke events. The recently introduced weighted all-cause hazard ratio was used which allows a weighting of the competing endpoints in a composite endpoint. We extended this approach to allow adjustment for covariates. The investigated risk factors were atrial fibrillation, hypertension, diabetes mellitus, smoking, and hypercholesterolemia adjusting for age and sex. Results : None of these meanwhile treated risk factors of which some have been modified after first stroke remained to be associated with subsequent death or stroke. Cause-specific effects point sometimes into opposite directions. Conclusions : Using the new weighted hazard ratio, we can support that well established risk factors for the occurrence of an index stroke are no good predictors of further disease progress defined by death or recurrent stroke. It has been demonstrated that the new weighted hazard ratio provides interpretation advantages over the common all-cause hazard ratio.
Geographic differences in relationship between socioeconomic, clinical, urban-rural factors and stroke incidence in France
Authors: Padilla Cindy.M , Foucault Anais , Grimaud Olivier , Nowak Emmanuel , Timsit Serge
Published: December 2019

Background: Stroke remains a devastating disease in Europe and geographic disparities persist. Mapping spatial distributions of disease occurrence can serve as a useful tool for identifying exposures of public health concern. The purpose of this study was to investigate geographic differences in relationship between socioeconomic, clinical, urban-rural factors and stroke incidence in Pays de Brest (Western France) between 2008 and 2013.Methods: We used cases and patient’s characteristics from the Brest stroke registry, and sociodemographic, urban –rural indicators constructed at the census blocks level. We generated maps using Poisson geographic weighted regression models, smoothing on longitude and latitude while adjusting for covariates. Results: Women living in more deprived census blocks evidenced a significantly higher age standardized stroke incidence risk 1.24, [95%CI 1.09-1.39] and 1.21, [95%CI 1.04-1.49], in rural and urban census blocks respectively. For men, three clusters of census blocks with high stroke incidence risk were detected, one in rural and deprived and two in urban and low deprived census bocks. Conclusions: Understand whether and how neighborhood and patient’s characteristics influence stroke risk, may be useful for both epidemiological research and health services planning.
Key Barriers to the Provision and Utilization of Mental Health Services in low-and Middle-Income Countries: A Scope Study
Authors: Sarikhani Yaser , Bastani Peivand , Rafiee Mohammad , Kavosi Zahra , Ravangard Ramin
Published: December 2019

Background: Mental Health(MH) is among the main determinants of community well-being and a remarkable portion of global burden of diseases is pertaining to mental disorders. Despite this fact, little attention has been given to the provision of adequate and appropriate MH services and improving equitable access to these services in some parts of the world especially in low-and middle-income countries(LMICs). This review was aimed to identify key barriers to the provision and utilization of MH services in LMICs. Methods: We carried out a systematic and comprehensive search on 7 important online databases for English-language literature on key barriers to the provision and utilization of MH services in LMICs from Jan 2000 to Nov 2019. Arksey and O’Malley instructor was used in 5 steps to implement scope study. The extracted materials were tabulated and synthesized using a qualitative content analysis approach. Results: Three main themes were developed regarding the barriers to the provision of MH services in LMICs including resource and administrative barriers, information and knowledge obstacles, as well as policy and legislation barriers. Also four main themes emerged about barriers to the utilization of MH services including attitudinal, structural, knowledge, and treatment-related barriers. Conclusion: Equitable access to MH services in LMICs is under influence of many barriers in both provision and utilization sides. In order to alleviate these problems, health systems in LMICs could adopt some strategies including integration of MH policy into general health policy, improvement of public MH knowledge regarding the MH and its related issues, developing anti-stigma programs, reallocation of health resources toward high-priority MH needs, developing community-based insurance, as well as integration of MH services into all levels of health-care systems. Further studies are also required for determining relative importance of the barriers and their related solutions based on the national context of each country.
Toxic effects of dechlorane plus on the common carp (Cyprinus carpio) embryonic development
Authors: Li Baohua , Chen Jianjun , Du Qiyan , Wang Beibei , Qu Ying , Chang Zhongjie
Published: December 2019

Dechlorane Plus (DP) is a widely using chlorinated flame retardant, and has been detected extensively in the environment. Even though the DP content in the surface water is low, it can pose a continuous exposure risk to aquatic organisms due to its strong bioaccumulation. Since related researches on the toxicity mechanism of DP exposure on carp embryo development are limited, we carried out the evaluation of DP effect on carp. In this study, Carp embryos were exposed to DP of 0, 30, 60, and 120 µg/L at 3h post fertilization (hpf). The expression of genes associated with the neural and skeletal development such as sox2, sox19a, Mef2c, and BMP4 were evaluated using quantitative PCR (qPCR), and analysis of different developmental toxicity endpoints changes were observed with microscopy. Our results demonstrated that the expression of sox2, sox19a, Mef2c, and BMP4 were significantly changed and several developmental defects were observed in the exposed carps embryo, such as DNA damage, increased mortality rate, delayed hatching time, decreased hatching rate, decreased body length, increased morphological deformities. In addition, reactive oxygen species (ROS) and malondialdehyde (MDA) were significantly increased with DP exposure at 60µg/L and 120 µg/L. Altogether, our results suggest that DP may have an unique modes of action, which results in aberration occurrence in the early development stage of common carps, that may relates to some gene damage and oxidative stress. Besides, the parameters evaluated here can be used as tools to access the environmental risk for biota and humans exposed to DP.
Health TAPESTRY Ontario: Protocol for a Randomized Controlled Trial to Test Replicability and Implementation
Authors: Mangin Dee , Lamarche Larkin , Bomze Sivan , Borhan Sayem , Browne Tracy , Carr Tracey , Datta Julie , Dolovich Lisa , Howard Michelle , Marentette-Brown Sarah , Oliver Doug , Risdon Cathy , Talat Samina , Tarride Jean-Eric , Thebane Lehana , Valaitis Ruta , Price David
Published: December 2019

Background: Health TAPESTRY (Health Teams Advancing Patient Experience: STRengthening qualitY) aims to help people stay healthier for longer where they live by providing person-focused care through the integration of four key program components: 1) trained volunteers who visit clients in their homes, 2) an interprofessional primary health care team, 3) use of technology to collect and share information, and 4) improved connections to community health and social services. The initial randomized controlled trial of Health TAPESTRY found promising results in terms of health care use and patient outcomes, indicating a shift from reactive to preventive care. The trial was based on one clinical academic centre, thus limiting generalizability. The study objectives are: 1) to test replicability of the established effectiveness of Health TAPESTRY on physical activity and hospitalizations, 2) to test the feasibility of, and understand the contributing factors to, the implementation of Health TAPESTRY in six diverse communities across Ontario, Canada, and 3) to determine the value for money of implementing Health TAPESTRY. Methods: This planned study is a pragmatic parallel randomized controlled trial with a delayed intervention for control participants at six months. This trial will simultaneously assess effectiveness and implementation in a real world setting (Type II hybrid) in six diverse communities across Ontario. Participants 70 years of age and older will be randomized into the Health TAPESTRY intervention or the control group (usual care). Intervention clients will receive an individualized plan of care from an interprofessional care team. The plan will be based on a client’s goals and current health risks identified through volunteer visits. The study’s outcomes are mapped onto the RE-AIM framework, with levels of physical activity and number of hospitalizations as the co-primary outcomes. The main analysis will be a comparison at six months. Discussion: It is important to evaluate the effectiveness and implementation of Health TAPESTRY in multiple communities prior to scaling or widespread adoption. Trial registration: ClinicalTrials.gov: NCT03397836 (posted January 12, 2018). https://clinicaltrials.gov/ct2/results?cond=&term=NCT03397836&cntry=&state=&city=&dist=
Impact of socioeconomic status on patient experience: A cross sectional exit survey of Nigeria Teaching Hospitals.
Authors: Aloh Henry Egi , Onwujekwe Obinna E. , Aloh Obianuju G. , Okoronkwo Ijeoma L. , Nweke Chijioke Joel
Published: December 2019

Background: To determine how socioeconomic factors, such as level of education and employment status, affect quality of ambulatory patient experience in Nigeria teaching hospitals.Methods: The study design is a cross-sectional exit survey. And the setting were outpatient departments of Nigerian Teaching Hospitals. Assessment of patient experiences for 5 domains of care, including waiting time, environment of the outpatient department, quality of doctor’s care, quality of care by nurses/other health workers, responsiveness of care and the overall quality of care was carried out using structured questionnaire.Results: The mean rating of quality of care or patient experience for the outpatients was 74.31 ± 0.32%. There were obvious but moderate differences among the hospitals for various levels of patients’ care, especially for waiting time, quality of doctors’ care and overall quality of care. Employment status was statistically significant (p ≤ 0.05) determinants of overall patient experience rating or quality of care for the outpatients, while the level of patient’s education was an influence on the waiting time perception by the patients and their rating of care from nurses/other healthcare providers, other than doctors. Conclusion: The study observed that socioeconomic factors such as educational and employment status of outpatients to some extent determines how outpatient perceived their experience while receiving healthcare in hospitals. Thus, there is need to institutionalize patient-centered care, giving full consideration to patients’ socioeconomic status.
Community-based rehabilitation service in Chengdu: a cross-sectional general survey
Authors: Chen Siliang , Lei Yi , Dai Hua , Wu Jia , Yang Ziyu , Liao Xiaoyang
Published: December 2019

Background Community-based rehabilitation (CBR) was initiated by World Health Organization in 1984, and by then it has been an essential process of medical services in the worldwide. China had strengthened primary health care via constructing more than 35 thousand community health centers (CHCs) in cities, and more than 35 thousand township health centers (THCs) in rural area. Nevertheless, it remains unclear that if these basic health center could provide optional rehabilitation services for disabilities. And this study aims at evaluating supply capacity of rehabilitation service in basic health centers of Chengdu, a regional center city of southwest China.Method We conducted a general investigation of primary health centers in Chengdu, a city located in south west China with more than 15 million population. Totally, our investigation covered 115 CHCs and 264 THCs from October to November 2016. We investigated these primary health center on basic rehabilitation services, disease spectrum and rehabilitation equipment quantity and quality, and traditional Chinese medicine (TCM) physiotherapyResult Rehabilitation therapy is available in 88.9% (337 of 379) of all community health centers, meanwhile, urban community health centers slightly surpass rural community with available rate of 92.2% (106 of 115) and 87.5% (231 of 264), respectively. Traditional Chinese Medicine (TCM) physiotherapy is available in 97.1% (368 of 379) of all community health centers, 97.3% (112 of 115) of urban community health centers and 97.0% (256 of 264) of rural community health centers. Quantitively analysis indicated that substantial factors which could make impact on number of patients per year contain: species of rehabilitation disease (P<0.001, 95% confidence interval (CI) [-1.571, -0.702]), the service population (P=0.03, 95%CI [-1.198,-0.057]), number of rehabilitation bed (P<0.001, 95%CI [-1.249,-0.290])Conclusion Community-based rehabilitation and TCM physiotherapy have become accessible for disabilities in neighbor community health centers of Chengdu City. Whereas, available rate of CBR in rural CHCs is lesser than in urban CHCs, which indicates imbalance in basic health service development between rural and urban area. A bit of baseline of CHCs makes significant impact on number of patients per year, including species of rehabilitation diseases, service population and number of rehabilitation bed.
Neuroprotective effect of astrocyte-derived IL-33 in neonatal hypoxic-ischemic brain injury
Authors: Jiao Mengya , Li Xiangyong , Wang Xiaodi , Chen Liying , Yuan Baohong , Liu Tao , Dong Qun , Mei Hanfang , Yin Hui
Published: December 2019

Background: Interleukin-33 (IL-33) is a well-recognized pleiotropic cytokine which plays crucial roles in immune regulation and inflammatory responses. Recent studies suggest that IL-33 and its receptor ST2 are involved in the pathogenesis of neurological diseases. Here, we explore the effect of IL-33/ST2 signaling in neonatal hypoxic-ischemic (HI) brain injury and elucidate the underlying mechanisms of action. Methods: The brain HI model was established in neonatal C57BL/6 mice by left common carotid artery occlusion with 90 min hypoxia, and treated with IL-33 at a dose of 0.2 μg/day i.p. for three days. TTC staining and neurobehavioral observation were used to evaluate the HI brain injury. Immunofluorescence and flow cytometry were applied to determine the expression of IL-33 and its receptor ST2 on brain CNS cells, cell proliferation and apoptosis. OGD experiment was used to assay the viability of astrocytes and neurons. RT-qPCR was used to measure the expression of neurotrophic factor-associated genes. Results: The expression level of IL-33 was markedly enhanced in astrocytes 24 h after cerebral HI in neonatal mice. Exogenous delivery of IL-33 significantly alleviated brain injury 7 d after HI, whereas ST2 deficiency exacerbated brain infarction and neurological deficits post HI. Flow cytometry analyses demonstrated high levels of ST2 expression on astrocytes, and the expression of ST2 was further elevated after HI. Intriguingly, IL-33 treatment apparently improved astrocyte response and attenuated HI-induced astrocyte apoptosis through ST2 signaling pathways. Further in vitro studies revealed that IL-33-activated astrocytes released a series of neurotrophic factors, which are critical for raising neuronal survival against oxygen glucose deprivation. Conclusions: The activation of IL-33/ST2 signaling in the ischemic brain improves astrocyte response, which in turn affords protection to ischemic neurons in a glial-derived neurotrophic factor-dependent manner.
Acceptability of screening for pregnancy intention in general practice: a population survey of people of reproductive age
Authors: Hammarberg Karin , Hassard Julie , de Silva Renee , Johnson Louise
Published: December 2019

Background: Optimal parental preconception health benefits reproductive outcomes. However, preconception health promotion is not routinely offered in primary health care settings to people of reproductive age. The aim was to gauge the planned preconception health behaviours and attitudes towards being asked about pregnancy intention by a general practitioner (GP) among people of reproductive age in Australia. Method: The research was conducted on a single wave of Australia’s first and only probability-based online panel, Life in Australia™. Members of the Life in Australia™ panel are Australian residents aged 18 years or over. All active members between the ages of 18 and 45 years were eligible to participate. Eligible panel members were invited to complete a survey about fertility and childbearing. Data were collected from 18 February to 4 March 2019. Results: In all 965 female and male members of Life in Australia™ aged between 18 and 45 years were invited to complete the survey. Of these, 716 (74.2%) agreed. Most respondents indicated that if they were planning to have a child they would try to optimise their preconception health by adopting a healthier diet (80%), seeing a GP for a health check-up (78%), reducing alcohol consumption (78% of those consuming alcohol), getting fitter (73%), and stopping smoking (70% of smokers). Three in four (74%) stated that they would not mind if their GP asked them about their pregnancy intentions. Conclusion: Findings suggests that routinely asking people of reproductive age about their pregnancy intentions and advising those who are planning pregnancy about what they can do to ensure optimal preconception health would be acceptable to most people and may improve reproductive outcomes.
Hospital Utilization for Non-Traumatic Dental Conditions in Oregon from 2013 to 2015
Authors: Brow Avery , Tranby Eric P. , Boynes Sean G
Published: December 2019

Poor oral health remains a national concern impacting overall health and continues to
burden an already overtaxed health care system. These issues are exacerbated by differing levels
of coverage nationally, particularly in those states that lack any public oral health coverage.
Those with significant and immediate need are forced to seek care from alternative settings and
often are not equipped to provide dental treatment. Oregon operates a unique system called
coordinated care organizations (CCOs) designed to link providers from across disciplines and
focus on prevention and chronic disease management.
Using claims data from the All-Payer, All-Claims (APAC) database, this paper evaluates
claims from 2013 to 2015 for all patients presenting to an emergency department (ED) or as an
inpatient for a non-traumatic dental condition (NTDC). ED visits for NTDCs increased from
2013 to 2015 with 79% of ED visits for a dental condition paid for by Medicaid, and those aged
20-34 had the highest visit rate across all 3 years. Black and American Indian or Alaskan Native
patients had the highest ED utilization. Residents of rural counties were more likely to utilize the
ED than urban counties. 76% of patients visited the ED 1 time with a charge of $13,888,516.
Consistent with other findings, the increased visits are likely due to expanded Medicaid
coverage. Increased usage by rural residents is supported by other studies. This paper continues
to demonstrate the need for multi-level solutions that continue to decrease ED utilization across
the state.
“CINE DE QUINTA”: CINEMA PARA ALÉM DO ENTRETENIMENTO
Authors: Corrêa Lays Matias Mazoti , Braga Cássio Caetano
Published: December 2019

Resumo: O “Cine de Quinta” foi desenvolvido na UFV, campus de Rio Paranaíba-MG com o objetivo principal de construir conhecimento junto a estudantes e moradoras/es de Rio Paranaíba por meio de ciclos fílmicos escolhidos semestralmente. O projeto teve início em 2017 e desde então tem colocado em pauta diversos assuntos inerentes à sociedade contemporânea, porém, muitas vezes negligenciados. Dessa forma, o “Cine de Quinta” usa o cinema como ferramenta principal na formação sociocultural das/os participantes, promovendo debates e instigando o público a desenvolver seu senso crítico através da “sétima arte”.Palavras-chave: Cinema, Entretenimento, Conhecimento.Área temática: Cultura e Educação
La interactividad y la conectividad al servicio de la industria de la confección
Authors: Vega Rodríguez Leidy Yaneth , Gaviria Fabio Andrés , Botero Luz Eugenia
Published: December 2019

Los rápidos avances en la industrialización e informatización han estimulado el desarrollo de procesos automáticos, precisos y sostenibles. La Industria 4.0 representa la evolución tecnológica integrada a los sistemas ciberfísicos, que combina sensores inteligentes, inteligencia artificial y análisis de datos para optimizar la fabricación en tiempo real. En este documento se explora el panorama de las nuevas tecnologías en el ámbito de la Industria 4.0, con la intención de brindar una perspectiva diferente que permita mejorar las técnicas tradicionales de desarrollo y fabricación de prendas de vestir y que facilite la respuesta permanente y rápida a los retos que se presentan en el mundo empresarial mediante la toma de decisiones inteligentes y responsables. El uso de tecnologías como Big Data o Cloud brinda la oportunidad de optimizar las operaciones y proporcionar valor agregado al integrar productos y servicios si se considera que se tiene una cadena de valor más compleja, canales digitales cada vez más importantes y un cliente más exigente. Muchas empresas del sector de la confección han adoptado estas tecnologías disruptivas, comprobando que tienen un profundo impacto en términos de productividad, calidad y servicio. Sin embargo, la falta de herramientas poderosas representa un obstáculo importante para explotar todo su potencial.
THE PHYSIOLOGY EFFECTS OF A FINNISH SAUNA ON AEROBIC EXERCISE IN COLLEGE-AGED INDIVIDUALS
Authors: Bogdanich Holly , Kiger Jan , Santos Julia Matzenbacher
Published: December 2019

Sauna baths acutely increases vasodilation, heart rate (HR) and muscle relaxation; therefore sessions of sauna have been tested as a therapeutic treatment for cardiovascular diseases and psychological diseases. When combined with exercise, sauna baths have been performed to accelerate exercise recovery, with the sauna being done post workout the majority of times. The aim of this study was to determine the effects of the sauna used prior to a bout of moderate intensity aerobic exercise. Eight volunteer performed a 20-minute treadmill aerobic exercise (running) 70% of maximal VO2 with and without a visit to the sauna. Systolic and diastolic blood pressure (BP), HR, and Rate of Perceived Exertion (RPE) were recorded before, halfway at 10 minutes, and after the aerobic exercise. Systolic BP, assessed before exercise, was not different when subjects performed prior sauna (124.8 ± 10.8 vs. 125± 11 mm/Hg no sauna and sauna, respectively). However, diastolic BP was lower in no-sauna condition vs. sauna condition while HR and RPE (73± 5 vs 80± 4.5 mm/Hg BP, 90±13 vs. 101±11 beats/min and 6 vs. 7 RPE no sauna and sauna, respectively). When the comparison was made within the experimental condition exercise, sauna attenuated the increase in systolic and diastolic BP induced by exercise without affecting HR and RPE. Extreme high temperatures experienced in sauna modulate cardiovascular system responses by increasing HR and diastolic blood pressure. Moderate exercise increases systolic and diastolic BP, which might be attenuated when sauna is performed prior to exercise. A Sauna session might be used to modulate the response of exercise towards BP.
EMPREGO DE ÓLEOS ESSENCIAIS COMO MATÉRIA-PRIMA PARA A PRODUÇÃO DE REPELENTES DE INSETOS
Authors: Coelho Angelica Gomes , Leal Ezequielina Raquel , De Vasconcelos Jeany Francisca Sampaio
Published: December 2019

Os óleos essenciais extraídos de plantas são comuns e popularmente empregados como alternativa aos repelentes sintéticos comercializados. Assim, o presente trabalho propõe-se a realizar uma revisão sistemática na literatura sobre o emprego de óleos essenciais na análise e desenvolvimento de formulações repelentes. Realizou-se uma busca por artigos científicos usando os descritores “Repellent*”, “Plant*”, “Essential* oil*” e “Cosmetic*”, nas bases de dados: SciELO e PubMed®. As publicações selecionas foram analisadas quanto ao país de origem; famílias mais estudadas; partes das plantas mais empregadas; métodos de extração empregados e tipo de formulações repelentes desenvolvidas. A busca realizada resultou em um total de 241 artigos científicos, em sua maioria do ano de 2015. Encontraram-se espécies das mais diferentes famílias, destacando-se a Asteraceae. Além disso a maioria das publicações é originária da China e do Brasil, sendo a folha a parte da planta mais utilizada e a hidrodestilação o método extrator mais prevalente. Contudo, a representativa pesquisa acerca dos óleos vegetais repelentes está associada à divulgação de apenas cinco formulações cosméticas repelentes, as quais possivelmente teriam maior segurança de uso e menor valor agregado. Tal fato pode significar, para o mercado cosmético brasileiro, o aproveitamento incompleto ou tardio das propriedades investigadas e comprovadas através dos estudos científicos.
AVALIAÇÃO SEXUAL E REPRODUTIVA DE MULHERES DA ZONA RURAL DE UMA CIDADE DO NORDESTE DE MINAS GERAIS
Authors: Amorim Patrícia Brandão , Silva Daniel Rodrigues , Carvalho Herli De Souza
Published: December 2019

A saúde brasileira precisa vencer paradigmas para se consolidar como referência no mundo globalizado, e a saúde reprodutiva é muito importante nesta conquista. O estudo foi realizado com 186 mulheres,onde 36% delas engravidaram na adolescência,a última gestação não foi planejada em 68% dos casos, e destas, 59% não utilizaram método anticoncepcional, 18% utilizaram erroneamente e 23% não tinha nenhuma informação sobre contracepção. Os métodos mais utilizados foram os anti concepcionais de via oral 41%, e a ligadura tubária em 49%, destas, 20% desconhecem o que é doença sexualmente transmissível. Somente 59% da população procuram preservativos e anticoncepcionais no setor público. O objetivo do estudo é verificar como é a assistência à saúde sexual e reprodutiva de mulheres na Estratégia de Saúde da Família (ESF) de zona rural do nordeste de Minas Gerais.
Cambio postincendio en la estructura y composición del estrato arbóreo y carga de combustibles en un bosque de Pinus douglasiana de México
Authors: Quintero-Gradilla Shatya Devi , Jardel-Peláez Enrique José , Cuevas-Guzmán Ramón , García-Oliva Felipe , Martínez-Yrizar Angelina
Published: December 2019

En los bosques de pino con un régimen histórico de incendios superficiales frecuentes de baja severidad, bajo condiciones extremas del estado del tiempo o a consecuencia de la supresión del fuego, la severidad de los incendios puede incrementar. La respuesta de la vegetación a eventos de incendios severos se estudió en una cronosecuencia postincendio de 8 años, 28 años y 60 años en un bosque dominado por Pinus douglasiana en México. La densidad de árboles con diámetro > 2.5 cm y su área basal alcanzaron valores de 1095 árboles ha-1 ± 609 árboles ha-1 y 10.0 m2 ha-1 ± 2.2 m2 ha-1 a los 8 años; a los 28 años el área basal (44.6 m2 ha-1 ± 3.0 m2 ha-1) fue cercana a la de los rodales de 60 años (49.0 m2 ha-1 ± 6.4 m2 ha-1). Los pinos mantuvieron el mayor valor de importancia con el tiempo postincendio, se observó la formación de un subdosel de latifoliadas tolerantes a la sombra y un aumento en la riqueza y diversidad de especies; también se documentó que periodos largos sin incendios incrementan la carga de combustibles superficiales ligeros (66.0 Mg ha-1 ± 5.5 Mg ha-1 en los sitios de 28 años y 61.5 Mg ha-1 ± 4.6 Mg ha-1 en los sitios de 60 años) y modifican el comportamiento del fuego (velocidad de propagación de 1.3 m s-1 a 4.1 m s-1 y la longitud de la llama de 0.7 m a 1.7 m entre los rodales de 8 años y los de 28 años y 60 años combinados). El manejo de los bosques de pino debe considerar el balance entre objetivos de conservación biológica y mitigación del peligro de incendios de alta severidad.
HEMOGLOBIN LEVELS AFTER CONSUMING THE INITIAL PHASE OF ANTITUBERCULAR DRUGS
Authors: SUSIWATI  , ZAMHARIRA MUSLIM
Published: December 2019

Objective: This study aims to determine the condition of the hemoglobin (Hb) level after the initial phase of antitubercular drug usage.

Methods: This research method used a descriptive survey design with the accidental sampling method. The sample of this study was 38 patients who met the inclusion criteria of the study. The sample was measured by Coulter Act-Diff Hematology Analyzer.

Results: This study shows the initial phase of antitubercular drugs (ATD) usage caused an abnormal hemoglobin level of 22 patients (58%) and 16 patients (42%) have a normal level. There are 12 (32%) male and 10 (26%) female patients have an abnormal level of Hb. The average of Hb level in tuberculosis (TB) patients is 12.42 (male) and 11.89 (female). This study also shows the correlation between body mass index with a Hb level of TB patient (p=0.001).

Conclusion: Hb levels in TB patients who consumed the initial phase of ATD were found to be mostly under normal.
Comparative effectiveness of pulmonary arterial hypertension drugs in treatment-naive patients: a network meta-analysis
Authors: Petrovič Maja , Locatelli Igor
Published: December 2019

Aim:
No network meta-analysis has been conducted to study efficacy of drug therapies specific for treatment of pulmonary arterial hypertension in treatment-naive patients only.
Methods:
Randomized controlled trials on pulmonary arterial hypertension-specific drug therapies were searched and a Bayesian network meta-analysis was performed. The 6-min walking distance (6MWD) and all-cause mortality were efficacy outcomes, whereas discontinuation due to adverse events was a safety-related outcome.
Results:
Analysis included 3.713 patients from 21 trials. Combination of ambrisentan and tadalafil showed the greatest impact on 6MWD, followed by epoprostenol and intravenous treprostinil (high dose). The latter two demonstrated marked effect size on mortality, although not statistically significant.
Conclusion:
According to 6MWD, ambrisentan/tadalafil combination was considered as most effective among all comparisons.

Prospero ID: CRD42019110832.
Una mirada desde la historia centroamericana
Authors: Monterrosa Cubías Luis Gerardo
Published: December 2019

En la presente reseña abordo el libro de Christiane Berth desde cuatro aspectos: su andamiaje teórico-metodológico, una crítica a la visión teleológica de la producción cafetalera, el apoyo de los finqueros alemanes al gobierno de Jorge Ubico (1931-1944) y las vicisitudes que la colonia alemana enfrentó en Guatemala después del estallido de la segunda guerra mundial. La obra comentada enriquece la historiografía sobre la región centroamericana y abre brechas para seguir estudiándola. El objetivo de esta reseña ha sido, precisamente, mostrarlas.
Estimation of Fibrinogen Level among Sudanese Patients with Myocardial Infraction
Authors: Edres Mohammed AL Mustafa Ahmed , Babiker Nihad Elsadig
Published: December 2019

Myocardial infraction (AMI) is an irreversible myocardial injury and necrosis caused by serious and long-term ischemia. It is generally seen in middle aged men with high risk factors for coronary artery disease. Only 4% of patients with AMI are under 40 years of age. This was a cross sectional study conducted at AL SHAB hospital, Khartoum, Sudan, aimed to estimate the fibrinogen level among Sudanese patients with myocardial infraction. 50 patients attending Alshab Hospital and diagnosed with MI used as a case group and 50 apparently healthy individuals with no history of MI were selected as control group. 1.8 ml of blood samples has been collected in sodium citrate anticoagulant container for measurement of fibrinogen level by clauss method in coagulometer device. It is clearly significant increase in fibrinogen level in myocardial infraction patient (p.value 0.000). In addition, the prothrombin time and gender were insignificantly differences in (AMI) patients. In the other hand, age and smoking significantly increased as risk factor in myocardial infraction. This study concluded that fibrinogen level was significantly increased in Sudanese patients with  myocardial infraction.

Keywords: Myochardial Infraction, Fibrinogen, Prothrombin Time, Coagulometer
A EXIGIBILIDADE DA CONDUTA CONFORME A NORMA NA ESTRUTURA DO CRIME OMISSIVO IMPRÓPRIO
CONDUCT REQUIREMENT ACCORDS THE NORM’S STANDARD IN THE STRUCTURE OF IMPROPER OMISSIVE TORT
Authors: Gomes Junior Neuler Mendes , Silva Altamir Francisco da , Cantarelli Margarida de Oliveira
Published: December 2019

Este trabalho se dedica ao estudo e enfrentamento de problema que pode ser resumido no seguinte: o artigo 13 do Código Penal brasileiro, ao disciplinar o nexo de causalidade do crime omissivo impróprio, estabelece que a omissão só é penalmente relevante quando o omitente devia e podia agir para evitar o resultado. Este problema exigiu a busca por uma interpretação mais adequada do parágrafo segundo do artigo 13 do Código Penal brasileiro, que fosse dogmaticamente coerente e atenta à legalidade. Para isso, buscou-se identificar o momento de inserção legal do poder agir na estrutura do crime omissivo impróprio por meio de investigação histórica debruçada sobre o tratamento dessa espécie de estrutura punitiva nos Códigos Penais que antes vigeram em nosso país e em suas exposições de motivos, pretendendo-se, por meio disso, conhecer a vontade do legislador que a inseriu, o que poderia nortear a interpretação.
DIALOGANDO COM MARCELO NEVES SOBRE A (IM)POSSIBILIDADE DE UMA CONSTITUIÇÃO POLÍTICA PARA A SOCIEDADE MUNDIAL PLURALISTA
DIALOGGING WITH MARCELO NEVES ABOUT THE (IM) POSSIBILITY OF A POLITICAL CONSTITUTION FOR THE PLURALIST WORLD SOCIETY
Authors: Lima Jhéssica Luara Alves de , Morais Lindocastro Nogueira de , Lima Carmem Tassiany Alves de
Published: December 2019

O presente artigo objetiva refletir sobre a (im)possibilidade da existência de uma constituição política para uma sociedade mundial pluralista. Para tanto, a reflexão parte do texto “Uma Constituição Política para uma Sociedade Mundial Pluralista?”, escrito pelo filósofo e sociólogo alemão Jürgen Habermas e toma por base as teo-rias do jurista brasileiro Marcelo Neves, autor com o qual o presente trabalho pre-tende tecer um diálogo. Pretende-se, ainda, constatar se as teorias do jurista Marcelo Neves em torno da (im)possibilidade de uma constituição global se mostram sus-tentáveis nos tempos hodiernos de crise constitucional. Para o desenvolvimento do artigo, far-se-á de início uma contextualização e ponderação sobre o texto base do estudo para fins de refletir sobre a ideia de uma constituição global. Como metodo-logia, a pesquisa contará com uma pesquisa bibliográfica, assentada basicamente nas obras jurídicas do jurista Marcelo Neves, trabalho este apoiado no método do raciocínio sintético e silogístico. A relevância da pesquisa se dá diante do cenário mundial de crise nas instituições e necessidade de defesa do sistema constitucional para a consolidação de uma sociedade democrática. Como considerações finais, constatou-se que é inviável uma única constituição política para a sociedade mundial pluralista.
Aspectos culturais que dificultam a participação das mulheres na política eleitoral e sua relação com as esferas público-privada
Authors: Lolatto Simone
Published: December 2019

O objetivo deste artigo é lançar uma breve análise sobre o processo de exclusão das mulheres dos espaços públicos, associado a componentes culturais, conformando uma baixa participação de mulheres na política eleitoral. Para tanto se recorreu a um levantamento bibliográfico a partir da pesquisa realizada durante o desenvolvimento da tese de doutorado da autora. São feitas reflexões acerca da dicotomia das esferas pública e privada, sobre a importância da representação descritiva do ponto de vista da democracia de gênero, mas, fundamentalmente, como o processo de empoderamento e a identificação de mais mulheres parlamentares com os feminismos potencializaria a maior representação substantiva e portanto o compromisso com as reivindicações feministas e as políticas públicas que geram avanços nos direitos para as mulheres.
Qual a característica da campanha online de mulheres candidatas? Uma análise a partir das eleições brasileiras de 2018
Authors: Quesada Tavares Camilla , Nascimento de Sousa Nayara
Published: December 2019

Tem-se como objetivo investigar quais as características das campanhas no Facebook feitas por mulheres candidatas às eleições de 2018. Considerando que as mulheres recebem poucos incentivos dos partidos para disputarem cargos públicos, redes sociais digitais representam uma possibilidade de equilibrar a campanha entre os atores, já que nos espaços tradicionais, como rádio e TV, elas tendem a obter menos tempo do que candidatos homens. Busca-se compreender quais as estratégias de campanha utilizadas por elas nas fanpages do Facebook, tendo como foco as questões de gênero. Para atingir esses objetivos, são analisadas as campanhas de seis candidatas com diferentes trajetórias na política. O corpus é composto por 1.958 postagens realizadas durante o primeiro turno da campanha eleitoral nas fanpages do Facebook, e a metodologia é de análise de conteúdo quantitativa. Resultados indicam que as candidatas pouco apresentam um discurso que aborde gênero, e quando o fazem é de forma a reforçar estereótipos.
Gauging the acceptance and the attitudes of rural workers in the semiarid region of northeastern Brazil concerning the artisanal production and consumption of Spirulina platensis
Authors: Santana Jordana Kaline da Silva , Sassi Cristiane Francisca da Costa , Pessoa Viviany Silva , Sassi Katharina Kardinele Barros , Sassi Roberto
Published: December 2019

Alternative foods that could diminish traditional nutritional deficits in human populations through new processes and new materials have been investigated in numerous recent publications. Within this context, the cyanobacterium Spirulina platensis has attracted a good deal of attention due to its high protein content and the presence of polyunsaturated fatty acids, pigments, salts, and vitamins. Seventy-five rural workers from the municipality of Frei Martinho, semiarid region of Paraíba State, Brazil. Participated in the present research that evaluated the acceptability of S. platensis as a food supplement. We evaluated their attitudes in terms of the possibility of cultivating that microalgae, if they would be open to dietary changes (innovative attitudes) or refractory to them (conservative attitudes), their attitudes towards possible artisanal cultivation of S. platensis, Laboratory cultures were prepared using synthetic media and the microalgae biomass was used for producing cakes, juices, and cookies; “in natura” or dried materials were also tested for acceptability, as well as their inclination to buy products based on Spirulina. The observed acceptability indices of were higher than expected (70%) for all of the attributes evaluated (appearance, odor, and texture) in three different presentations (“in natura”, dry, and incorporated into foods), except for the variable of odor in the “in natura” form (66.12%). In terms of intentions to buy, 88% of the interviewees confirmed that they would buy supplemented products if they were available. The attitude tests showed a consistent internal positive view of Spirulina, indicating that the agricultural workers tested were open to technological innovations.
COMO OS PROFESSORES DE BIOLOGIA CONCEBEM A DIVERSIDADE CULTURAL: INFLUÊNCIAS PARA O DIÁLOGO INTERCULTURAL E PROPOSTA PARA A FORMAÇÃO DOCENTE
Authors: Bispo Maria das Graças de Santana , Baptista Geilsa Costa Santos
Published: December 2019

Este artigo apresenta e discute os resultados de uma pesquisa qualitativa que teve por objetivo identificar quais são as concepções que os professores de biologia possuem acerca da diversidade cultural presente nas escolas onde atuam e como essas concepções podem influenciar no diálogo intercultural. Realizamos entrevista semiestruturada com 5 professores de biologia e as análises aconteceram de maneira indutiva e em diálogo com a literatura da área de ensino de ciências, a partir de transcrição e categorização. Nossos resultados apontam que os professores concebem como importante a consideração da diversidade cultural, embora existam dificuldades que remetem às suas formações inicial e/ou continuada. Sugerimos abordagens que contribuam para a formação docente culturalmente sensível, o que inclui dimensões da história e da filosofia da ciência bem como da etnobiologia.
O INDÍGENA NO IMAGINÁRIO ALEGÓRICO DOS BUMBÁS DE PARINTINS
Authors: Nakanome Ericky da Silva , Silva Adan Renê Pereira da
Published: December 2019

Alegoria é um cenário móvel, suporte cenográfico para apresentação de parte do espetáculo dos bumbás. O estudo objetivou compreender a construção do indígena no imaginário alegórico do boi-bumbá de Parintins, Amazonas, Brasil, por meio de pesquisa etnográfica, focando-se no ritual indígena. O resultado evidencia a mescla do parintinense indígena e construtor da festa, tornando a visão do índio romantizada e espetacularizada simultaneamente.
O PLÁGIO INVENTIVO: REESCRITURA, REENCENAÇÃO, REMONTAGEM, RETEATRALIZAÇÃO E REPERFORMATIZAÇÃO
Authors: Beigui Alex
Published: December 2019

Através do presente artigo, procuramos discutir a ideia de “plágio inventivo” no contexto da cena contemporânea. Para tanto, apresentamos de maneira sucinta um percurso dos elementos que conduziram ao espaço do plágio, suas contradições e diferenças em relação à cópia e a alguns conceitos afins como o de mímesis e o de simulacro. A partir da problemática entre a “originalidade” e a representação, analisamos algumas experimentações, enquanto campo metodológico de criação.