bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of Variants in FCGR2A, PTPN2, and GM-CSF with Cerebral Cavernous Malformation: Potential Biomarkers for a Symptomatic Disease
Authors: da Fontoura Galváo Gustavo , Fontes-Dantas Fabrícia Lima , da Silva Elielson Veloso , Alves-Leon Soniza Vieira , de Souza Jorge Marcondes
Published: June 2021

Backgrounds:

Cerebral Cavernous Malformations (CCM) predispose patients to a lifetime
risk of seizures and symptomatic hemorrhage. Only a small percentage of people affected will
develop clinical symptoms and the molecular mechanisms underlying lesional activity remain unclear.
We analyzed a panel of Single Nucleotide Polymorphisms (SNPs) in CCM patients. We
looked for plasmatic inflammatory cytokines, checking for a pattern of plasma expression heterogeneity
and any correlation with genetic variations identified with different CCM clinical phenotypes.

Methods:

This was a case-control study from a long-term follow-up cohort including 23 CCM patients,
of which 16 were symptomatic, and 7 were asymptomatic. A 200-SNP panel was considered
through next-generation sequencing and 18 different plasma molecules were assessed through a suspension
array system.

Results:

Fcγ receptor IIa rs1801274 (FCGR2A) and protein tyrosine phosphatase non-receptor type
2 rs72872125 PTPN2 were statistically different between groups. Patients who had a combination
of the presence of FCGR2A and the absence of PTPN2 also had symptoms earlier in life. The combination
of genetic polymorphisms and serum level of GM-CSF showed the best diagnostic biomarker
to distinguish symptomatic patients as formulated: [0.296*(FCGR2A)] + [-0.788*(PTPN2)]
+ [-0.107*(GM-CSF)].

Conclusion:

We have shown that SNPs in inflammation genes might be related to a symptomatic
phenotype in CCM. We also demonstrated that a formula based on two of these polymorphisms
(FCGR2A+ and PTPN2+) is possibly capable of predicting a symptomatic phenotype during a patient’s
lifetime.
Amino Acid Derived Prodrugs: An Approach to Improve the Bioavailability of Clinically Approved Drugs
Authors: Singh Yogesh , Saklani Samriti , Tantra Tanmoy , Thareja Suresh
Published: June 2021

Amino acids derived prodrugs emerged as an attractive approach to improve oral delivery
of drugs with low solubility and permeability. Conjugation of amino acids with parent drug
molecules resulted in several-fold increases in water solubility. Acceptability of the amino acids derived
prodrug approach increases day by day to fulfill the different characteristics needed to get the
desired pharmacological or therapeutic activity. Due to the significant structural diversity of amino
acids, various amino acids can be employed as a carrier to provide desirable Pharmacokinetic-Pharmacodynamic
(PK-PD) characteristics. The present review focused on using amino acids as a carrier
moiety to improve approved drugs' bioavailability. Attempts have been made to cover amino
acid conjugated clinically available drugs.
Synthesis of Substituted -N-(5-((7-Methyl-2-Oxo-2H-Chromen-4-yl)-
Methyl)-1,3,4-Thiadiazol-2-yl)-Benzamide Derivatives Using TBTU as
Coupling Agent and their Evaluation for Anti Tubercular Activity
Authors: Kakadiya Monika , Pasha Yunus , Noolvi Malleshappa , Patel Ashish
Published: June 2021

Tuberculosis remains a highly infectious disease across the world. In the identification of
new antitubercular agents, coumarin clubbed thiadiazole amides have been synthesized and evaluated
for in vitro antitubercular activity. Owing to the growing concern of chemicals and their impact on the
environment, greener and faster reaction conditions needed to be incorporated. Therefore, we used
TBTU as a coupling reagent for efficient and facile synthesis of substituted-N-(5-((7-methyl-2-oxo-2Hchromes-
4-yl)-methyl)-1,3, 4-thiadiazol-2-yl)-benzamide 4a-j with good yields up to 95% in mild reaction
conditions. All the synthesized compounds were evaluated in vitro for anti-tubercular activity
against the H37Rv strain of M. tuberculosis. Compounds 4c, 4d, and 4f were found active at 12.5
μg/mL against M. tb H37Rv. Electron withdrawing substituents present on aromatic side chains showed
promising anti-tubercular activity.
3D-QSAR, Docking, and Molecular Dynamics Simulations Studies on Quinazoline Derivatives as PAK4 Inhibitors
Authors: Chen Xiao-Zhong , Dai Chen , Shen Yan , Wang Juan , Hu Yong , Wang Yuan-Qiang , Lin Zhi-Hua
Published: June 2021

Background:

The p21-activated kinases 4 (PAK4) refer to a promising target for cancer
treatment. Currently, a wide range of PAK4 inhibitors has been reported.

Objective:

The objective of this study is to study the structural requirements of quinoline derivatives
as PAK4 inhibitors and to design novel PAK4 inhibitors.

Methods:

In the present study, a set of quinazoline PAK4 inhibitors underwent CoMFA, CoMSIA,
molecular docking, as well as molecular dynamics simulations.

Results:

The built CoMFA (q2=0.595, r2=0.986, r2
pred =0.689) and CoMSIA (q2=0.762, r2=0.984,
r2
pred=0.822) models exhibited high robustness and prominent predicting ability. As revealed from
the results of molecular docking and molecular dynamics simulations, hydrogen bond and
hydrophobic interactions primarily impact the affinity of PAK4 inhibitors, and Leu398 acts as an
amino acid that leads to significant stabilization of the mentioned inhibitors. Moreover, the present
study developed five novel molecules exhibiting high biological activity predicted and satisfactory
ADME properties.

Conclusion:

The structural basis of PAK4 with respect to the activities of its inhibitors was revealed,
which may be conducive to designing novel PAK4 inhibitors.
A Comparative Effectiveness Systematic Review and Meta-analysis of
Drugs for the Prophylaxis of Junctional Ectopic Tachycardia
Authors: Mendel Brian , Christianto Christianto , Setiawan Moira , Prakoso Radityo , Siagian Sisca Natalia
Published: June 2021

Background:

Junctional Ectopic Tachycardia (JET) is an arrhythmia originating from
the AV junction, which may occur following congenital heart surgery, especially when the intervention
is near the atrioventricular junction.

Objective:

The aim of this systematic review and meta-analysis is to compare the effectiveness of
amiodarone, dexmedetomidine, and magnesium in preventing JET following congenital heart
surgery.

Methods:

This meta-analysis was conducted according to the Preferred Reporting Items for Systematic
Review and Meta-Analysis (PRISMA) statement, where 11 electronic databases were searched
from the date of inception to August 2020. The incidence of JET was calculated with the relative
risk of 95% Confidence Interval (CI). Quality assessment of the included studies was assessed using
the Consolidated Standards of Reporting Trials (CONSORT) 2010 statement.

Results:

Eleven studies met the predetermined inclusion criteria and were included in this meta-analysis.
Amiodarone, dexmedetomidine, and magnesium significantly reduced the incidence of postoperative
JET [Amiodarone: risk ratio 0.34; I2= 0%; Z=3.66 (P=0.0002); 95% CI 0.19-0.60.
Dexmedetomidine: risk ratio 0.34; I2= 0%; Z=4.77 (P<0.00001); 95% CI 0.21-0.52. Magnesium:
risk ratio 0.50; I2= 24%; Z=5.08 (P<0.00001); 95% CI 0.39-0.66].

Conclusion:

All three drugs have shown promising results in reducing the incidence of JET. Our
systematic review found that dexmedetomidine is better in reducing the length of ICU stays as well
as mortality. In addition, dexmedetomidine also has the least pronounced side effects among the
three. However, it should be noted that this conclusion was derived from studies with small sample
sizes. Therefore, dexmedetomidine may be considered as the drug of choice for preventing JET.
Single-molecule Force Microscopy: A Powerful Tool for Studying the
Mechanical Properties of Cell Membranes
Authors: Shi Yan , Cai Mingjun , Wang Hongda
Published: June 2021

Background:

Cell membrane is a physical barrier for cells, as well as an important
structure with complex functions in cell activities. The cell membrane can not only receive external
mechanical signal stimulation and make response (e.g. cell migration, differentiation, tumorigenesis,
growth), but it can also spontaneously exert force on the environment to regulate cell activities
(such as tissue repair, tumor metastasis, extracellular matrix regulation, etc.).

Methods:

This review provides the introduction of single-molecule force methods, as atomic
force microscopy, optical tweezers, magnetic tweezers, micropipette adhesion assay, tension
gauge tethers and traction force microscopy.

Results:

This review summarizes the principles, advantages and disadvantages of single-molecule
force methods developed in recent years as well as their application in terms of force received
and generated by cells. The study of cell mechanics enables us to understand the nature of mechanical
signal transduction and the manifestation of the cell's own movement.

Conclusion:

The study of the mechanical properties of cell microenvironment leads to a gradual
understanding of the important role of cell mechanics in development, physiology and pathology.
Recently developed combined methods are beneficial to further study of cell mechanics. The optimization
of these methods and the invention of new methods enable the continuing research on
cell mechanics.
Excellent Eco-friendly Selective Alcohols Oxidation by an Acid Functionalized
Imidazolium Based Ionic Liquid
Authors: Karthikeyan Parasuraman , Deepa Manickam , Uthayanila Selvarasu , Ganesh Gopalsamy Selvaraj , Priya Ramasamy Shanmuga
Published: June 2021

Aims:

A green route for the oxidation of alcohols to corresponding carbonyl compounds in room temperature ionic liquid ([CEMIM]BH4) was developed by using hydrogen peroxide as the oxygen source. In aqueous solution at room temperature, 0.2 mol% of ([CEMIM]BH4) showed excellent catalytic properties for selective oxidation of aromatic and aliphatic alcohols

Background:

One of the vital reactions in organic synthesis is the oxidation of alcohols to carbonyl compounds. In particular, the conversion of primary alcohols to aldehydes has received a variety of applications as they are used as intermediates in fine chemicals mostly for the perfume industry.

Objective:

In the present work, we have reported an effective green route for the selective oxidation of alcohols to the carbonyl compounds using peroxide in an ionic liquid 1-carboxyethyl-3-methyl-imidazolium tetrahydroborate ([CEMIM]BH4)

Methods::

A mixture of alcohol (2 mmol), ([CEMIM]BH4) (0.2 mol%), H2O2 (2 mmol) were stirred thoroughly with the help of a magnetic stirrer for 10 min at ambient temperature

Results:

The catalytic activity of ([CEMIM]BH4) is very effective, which reflects its good solvating nature during the oxidation.

Conclusion:

In conclusion, the series of experiments described represents a useful method for the oxidation of primary and secondary alcohols to carbonyl compounds at room temperature. The catalyst can be easily prepared and is therefore extremely cost-effective. The rapid reaction times for the substrates mean a large number of materials may be screened in parallel over a short period of time.
VICIOS DE LA LEY 1354 DE 2009
Authors: ARISMENDY MARTINEZ OSCAR
Published: June 2021

Se trata de un ejercicio metodológico que elabora un examen a las discusiones judiciales surgidas a propósito de la promulgación de la ley 1354/09, consistente en plantear que legitimar la reelección vía referendo lastima profundamente la democracia –por lo tanto–, hay que considerar seriamente, la tesis de Bobbio y Ferrajoli, relacionada con el respeto a los procedimientos formales implícitos en la democracia, que son los que nos liberan de la tiranía de las supuestas mayorías.
Editorial
Authors: ALARCON ORLANDO
Published: June 2021

La revista electrónica Derecho y Sociedad es una iniciativa del Departamento de Ciencias Jurídicas de la Universidad de Córdoba, de libre discusión, tiene como propósito, fomentar el estudio crítico e investigativo del derecho –especialmente–, el Derecho Público, los Derechos Humanos y el Derecho Ambiental, incluyendo las ciencias auxiliar y afines
Democracia, internet e intimidad. ¿Civismo anónimo?
Authors: Hernández Palma Oona
Published: June 2021

Uno de los grandes aportes del Internet y en especial de la denominada web 2 o social web, es la posibilidad de intercambiar opiniones y retroalimentar la información que en ella se halla, lo cual permite que el hombre acceda a distintas alternativas o herramientas a través de las cuales puede ejercer libremente su derecho a la libertad de expresión. El espacio que propicia el uso del Internet supone muchas formas de interacción, disponibles en cualquier momento y en las que no sólo se accede a información sino que también es posible generar y confrontar la existente. En este escrito, se pone de presente las inquietudes que surgen cuando frente a los riesgos que el Internet genera para el disfrute y protección de los derechos, particularmente el de la intimidad, se propone el anonimato como derecho, asumiéndose como la alternativa jurídica para que la libertad de expresión que alimenta la tecnología, no se debilite o afecte con los actos violentos a los que el ciudadano se expone cuando interactúa en el mundo virtual. El enfoque metodológico abordado es la reflexión alrededor de la admisibilidad de asumir un civismo anónimo en las democracias, se diserta en primer lugar sobre el papel de la libertad de expresión y las posibilidades que ofrece la tecnología para su ejercicio y con ello el rescate de la virtud de los griegos, seguidamente se expone el significado de la participación política y finalmente la fundamentación del anonimato como derecho y su pertinencia en las democracias contemporáneas en donde no es suficiente hablar sino también escuchar en medio de la diferencia y la pluralidad
Derechos humanos y el derecho a un ambiente sano
Authors: Kerguelén Durango Eduardo Arturo
Published: June 2021

En este artículo se pretende realizar un análisis de reflexión sobre la relación existente entre el derecho a un ambiente sano y los derechos humanos universales, tratando de incorporar su evolución y trascendencia histórica en los ámbitos social, político y económico. El ambiente sano es un derecho Constitucional fundamental, pues su violación atenta directamente contra la especie humana y, en consecuencia, con los derechos más fundamentales del hombre. La segunda parte, contempla el desarrollo económico frente al medio ambiente y la inminente necesidad de trazar políticas económico-ambientales, es decir aquellas políticas inclinadas a la defensa de lo ambiental sin que se frene el desarrollo industrial que permite mejorar la calidad de vida
La experiencia del caso de CEGRA: una propuesta de articulación en redes interuniversitarias e interinstitucionale
Authors: Basconzuelo Celia Cristina
Published: June 2021

En la República Argentina, la idea que explicita el compromiso social de la universidad pública reconoce su antecedente en los postulados básicos de la Reforma Universitaria, episodio emblemático de la Córdoba de los claustros.2 Los jóvenes que impulsaron tal movimiento estudiantil tenían claro que la docencia y la investigación debían estar acompañadas por las actividades de extensión, entendida por entonces como “proyección” hacia el medio.
DERECHO Y ARGUMENTACIÓN
Authors: López  Sotomayor Telmo Alfonso , Soto García Omar
Published: June 2021

El propósito de este artículo es aportar algunas reflexiones en torno a la discusión de la única respuesta correcta, a partir de la postura de Robert Alexy, estableciendo sus concordancias y contraposiciones en relación con la tesis originalmente planteada por Ronald Dworkin, quien parte de la idea de un juez dotado de la capacidad y deber de interpretar acertadamente la norma superior en todos los casos. Para este autor, los textos constitucionales –en especial– los que enuncian los derechos fundamentales contienen básicamente una verdad sustancial y palpable aplicable a cada controversia jurídica, de tal manera que el intérprete debe ocuparse en descubrir esta única verdad, mediante la lectura moral de los principios. Al contrario, Robert Alexy sostiene que existen –al menos– tres formas de dar respuesta a un problema jurídico, primero racional, después práctico moral y finalmente jurídico; dando pie entonces para la apertura del debate sobre lo que es el derecho real y lo que debería ser. En tal caso, el dispositivo que articula estas tres formas, es la teoría de la argumentación jurídica. Desde la perspectiva alexiana, es imposible que exista una única respuesta para todo proceso jurídico. Los hallazgos indican que no existen aún medidas que hagan de esto, algo real; la idea de una única respuesta correcta es una utopía que promete un derecho perfecto donde cada veredicto y cada sentencia sea eficiente y complazca a todas las personas, sin embargo, esto actualmente no es posible
Psicología y Derecho
Authors: Arroyo Barón Steffany Edith , Negrete Doria Eduar Felipe , Avilez Pérez Luis Alberto
Published: June 2021

El objetivo general de este estudio es analizar la importancia de la aplicación de la técnica de la AP en los casos dudosos de homicidio y suicidio, ocurridos en Montería, durante el periodo 2010–2015 para responder a los siguientes interrogantes: ¿Con qué frecuencia se aplicó la técnica de la AP en estos casos en los periodos mencionados? Y en consecuencia ¿Qué tan objetiva son las investigaciones penales? La metodología se inscribe en el paradigma cualitativo, específicamente en una revisión de la literatura sobre la técnica de la autopsia psicológica, apoyada en encuestas aplicada a los funcionarios de la Fiscalía General de la Nación Seccional Montería, juzgados penales constituido por los jueces penales del circuito, Consejos Seccionales de la Judicatura, y Medicina legal y Ciencias forenses, quienes constituyen la población y muestra de este estudio. Este análisis condujo finalmente a las conclusiones que aparecen al final de este artículo. El cuerpo teórico de este estudio está sustentado sobre las teorías de la complejidad de Edgar Morín y la transdisciplinariedad del derecho penal. Asimismo, como marco jurídico se tomó como referencia la sentencia T- 708/10 de la Corte Constitucional Colombiana. Finalmente, como resultado de esta investigación se encontró que la autopsia psicológica, pese a ser un instrumento eficaz de la criminología y medicina forense no se aplica en la ciudad de Montería por desconocimiento de las autoridades judiciales y por falta de política criminal para su implementación.
Organizaciones cooperativistas de crédito en río cuarto, argentina. Actores sociales e identidades al promediar los años 1960
Authors: Basconzuelo Celia Cristina
Published: June 2021

El cooperativismo representa una de las estructuras organizacionales propias de la modernidad y característica de sociedades capitalistas contemporáneas. En Argentina, los primeros ensayos cooperativistas se explican en el marco de la llegada de dirigentes europeos quienes acreditan una importante trayectoria en prácticas mutualistas y comunitarias. Respecto del cooperativismo de crédito, se desarrolla a través de cinco modalidades históricamente diferentes, entre las cuales destacan las Cajas de Crédito (en adelante CC). Este trabajo, realizado sobre la base de un estudio de caso, tiene el propósito general de realizar un nuevo aporte al conocimiento de la CC que actúa en Río Cuarto a partir de noviembre de 1965, fecha de su creación institucional. El objetivo específico de este trabajo es pues analizar la composición social de la CC riocuartense y sus configuraciones identitarias en el momento fundacional. Las fuentes son periodísticas, entrevistas semi estructuradas y la publicación cooperativista Acción, fundada el 1 de abril de 1966.
Feasibility of Mobile Health and Social Media–Based Interventions for Young Adults With Early Psychosis and Clinical Risk for Psychosis: Survey Study (Preprint)
Authors: Franco Olivia H , Calkins Monica E , Giorgi Salvatore , Ungar Lyle H , Gur Raquel E , Kohler Christian G , Tang Sunny X
Published: June 2021

BACKGROUND

Digital technology, the internet, and social media are increasingly investigated as promising means for monitoring symptoms and delivering mental health treatment. These apps and interventions have demonstrated preliminary acceptability and feasibility, but previous reports suggest that access to technology may still be limited among individuals with psychotic disorders relative to the general population.

OBJECTIVE

We evaluated and compared access to and use of technology and social media in young adults with psychotic disorders (PD), young adults with clinical risk for psychosis (CR), and psychosis-free youths (PF).

METHODS

Participants were recruited through a coordinated specialty care clinic dedicated toward early psychosis as well as ongoing studies. We surveyed 21 PD, 23 CR, and 15 PF participants regarding access to technology and use of social media, specifically Facebook and Twitter. Statistical analyses were conducted in R. Categorical variables were compared among groups using Fisher exact test, continuous variables were compared using 1-way ANOVA, and multiple linear regressions were used to evaluate for covariates.

RESULTS

Access to technology and social media were similar among PD, CR, and PF participants. Individuals with PD, but not CR, were less likely to post at a weekly or higher frequency compared to PF individuals. We found that decreased active social media posting was unique to psychotic disorders and did not occur with other psychiatric diagnoses or demographic variables. Additionally, variation in age, sex, and White versus non-White race did not affect posting frequency.

CONCLUSIONS

For young people with psychosis spectrum disorders, there appears to be no “technology gap” limiting the implementation of digital and mobile health interventions. Active posting to social media was reduced for individuals with psychosis, which may be related to negative symptoms or impairment in social functioning.
Detection of AtRKD4 Protein During Induction of Somatic Embryogenesis in Dendrobium lineale Rolfe Transgenic Orchids Carrying 35S::GR::AtRKD4
Authors: Wirajagat Gde Cahyadi , Febryanti Ni Luh Putu Kayika , Puspitasari Fitriana , Sundari Dika , Gutierrez-Marcos Jose , Semiarti Endang
Published: June 2021

Dendrobium lineale is an Indonesian native orchid from the Spatulata section in Orchidaceae Family. This orchid is important because it is usually used as a parental plant in orchid breeding and is predicted to have a potential phytochemistry compound. In addition, in their natural habitat, this orchid is threatened due to forest exploitation and natural disaster. Therefore the precision mass propagation techniques for this orchid need to be conducted. Biotechnological approaches through inserting embryo gene such as AtRKD4 from Arabidopsis thaliana has already been successfully conducted. This study aims to check the integration stability of T-DNA harboring 35S::GR::AtRKD4 from ten selection transformants and to detect the existence of AtRKD4 protein after induction by Dexamethasone and/ Thidiazuron. The result showed that T-DNA were stably integrated into the genome of D. lineale transformants and the AtRKD4 protein with a molecular weight of 28.53 kDa was detected in D. lineale transformant plants after being induced by 15 µM DEX and 3 mgL-1 TDZ for 5 days.
Transferring Dematerialized Shares in Germany, Austria and in the United States of America
Authors: Baltov Rosen Petkov
Published: June 2021

The present article is aimed at briefly reviewing the historical development of dematerialized shares in Germany, Austria, and in the United States of America (the USA). A brief comparison is made between the dematerialized shares in the United Kingdom and those in Germany and Austria. Discussed is the reason why the securities certificates in Germany and Austria were removed from the transferring process by taking them out of circulation (immobilization), and not through abolishing them (dematerialization). Presented is the development of the most active and liquid capital market in the world—that of the United States Department of the Treasury. There is a brief description made of the System of the conventional paper certificates and the system of the dematerialized securities known as direct holding system, as well as of the System for immobilization and possessing through intermediaries, known as indirect holding system.In conclusion, there is a short presentation of the currently valid legal status unrelated to transferring dematerialized shares in the three countries.
Las asociaciones público privadas como mecanismo entre la provisión de servicios públicos o su privatización: el caso del Hospital Dr. Gonzalo Castañeda del ISSSTE
Authors: Martínez Espinoza Yanella
Published: June 2021

El documento se integra por cuatro apartados y dos anexos, estos últimos forman parte del análisis del estudio empírico. El primer capítulo se enfoca en el marco conceptual y analítico sobre el origen de las APP como mecanismo de mercado para la provisión de los servicios públicos partiendo de los fundamentos teóricos de la NGP. El segundo, busca conocer cómo ha sido el desarrollo de los esquemas de APP en otros países para entender su establecimiento en México. El tercer capítulo busca explicar cómo funciona y cuál ha sido el proceso de establecimiento de las APP en México. Y finalmente, el cuarto capítulo, se centra en el análisis empírico, lo que se busca es identificar, a través de estudios de caso, el proceso de implementación de los proyectos de APP en el sector salud.
The Art Of Social Work In Indonesia
Authors: Husein Asmar , Raharjo Santoso Tri , Hidayat Eva Nuriyah
Published: June 2021

Social work is a unique relief profession as unique as individuals, groups and societies. Social relations as the main media in performing the art of social work practice. The art of social work practice is an expression of intuition results that creates creativity in dealing with social problems. In this century, it is necessary to show a brand new model of social work practice along with the emergence of contemporary social problems. So that in the Indonesian context, a unique character and characteristic are needed. This journal is a literature review from various sources that aims to present the new concept of the art of social work practice in Indonesia. So far, the science of social work has not been sufficient in dealing with social problems. Here is the urgency and connection between science and the art of social work practice. Thus, the relationship between the two cannot be separated. Because, basically, within the practice of social work lies an art.
The Art Of Social Work Practices In Indonesia The Impact of LSSR Policy on the Socio-Economic Sector in Banten Province
Authors: Amin Muhammad , Samputra Palupi Lindasari
Published: June 2021

The Covid-19 pandemic is attacking the world, and measures are being taken to control the virus’s spread. Banten’s government is prohibited from enforcing the LSSR policy, which is based on Governor of Banten Decree 443 / Kep. 140-Huk / 2020 on the Establishment of Large-Scale Social Boundaries. This research employed quantitative descriptive method to determine if the LSSR impacts reducing the spread of the Covid-19 virus, as well as on the community’s social and economic well-being. The results indicated that unemployment would rise to 172 thousand by 2020. The poverty rate increased by 134.57 thousand. Income per capita decreases to 11,994 from 12,267 in 2019. The Human Development Index, which experienced a slowdown in growth in 2020, increased 0.01 points from 0.49 points the previous year. With an improvement of 0.15 points in the total length of schooling, it is greater than the 0.12point increase in 2019. The study recommends that the LSSR policy be maintained in order to prevent the spread of the Covid-19 virus, and that the government undertake fiscal stimulus efforts to improve the sustainability of micro, small, and medium-sized enterprises.
DAMPAK SOSIAL KONFLIK ETNIK DI KINALI 1999-2010
Authors: Ibrahim Welly , Ansofino Ansofino , Huda Ahmad Nurul
Published: June 2021

Kinali is an area inhabited by diverse ethnic with different cultures, namely Minangkabau, Mandailings, and Java. The area consists of diverse ethnic, there is always the potential for conflict. The conflict in 1999 between ethnic Minang and Mandailing in the wake of misunderstanding between the two warring ethnic ie ethnic Mandailing ethnic Minang and eventually led to a major conflict anarchistic. The impact of the conflict in the district Kinali West Pasaman on society viewed from social and cultural factors that people prefer not to socialize and interact with other ethnic groups, the social and economic factors of conflict have an impact on the decrease in public income and region for post-conflict societies choose to not interact and one of which is not to the market. Social factors are political, namely the attitude of the ethnic Mandailing are not adaptive in the pattern of relationship with the dominant culture in Kinali caused by the attitude of discriminative ethnic Minang in Kinali against ethnic Mandailing in various facets of life which they live for these finally bear aversion to mambaur and mingle normal and reasonable.Kinali adalah daerah yang ditinggali beragam etnik dengan latar budaya yang berbeda, yakni etnik Minankabau, Mandailing, dan Jawa. Daerah yang terdiri dari beragam etnik, selalu ada potensi munculnya konflik. Konflik yang terjadi pada tahun 1999 antara etnik Minang dan etnik Mandailing di latarbelakangi karena kesalahpahaman antara kedua etnik yang bertikai yaitu etnik Minang dan etnik Mandailing akhirnya berujung ke konflik besar yang bersifat anarkis. Dampak dari konflik di Kecamatan Kinali Pasaman Barat terhadap masyarakat dilihat dari faktor sosial budaya yaitu masyarakat lebih memilih untuk tidak bersosialisasi dan berinteraksi dengan etnik lain, pada faktor sosial ekonomi konflik berdampak kepada terjadinya penurunan penghasilan masyarakat dan daerah karena pasca konflik masyarakat memilih untuk tidak berinteraksi dan salah satunya tidak kepasar. Faktor sosial politik yaitu sikap orang etnik Mandailing yang tidak adaptif dalam pola hubungannya dengan kebudayaan dominan yang ada di Kinali disebabkan oleh sikap deskriminatif etnik Minang di Kinali terhadap etnik Mandailing dalam berbagai segi kehidupan yang mereka jalani selama ini yang akhirnya berbuah keengganan untuk mambaur dan bergaul secara normal dan wajar.
FUNGSI KOPERASI SERBA USAHA EKONOMI DESA (KSU-ED) TERHADAP MASYARAKAT NAGARI TABEK TALANG BABUNGO, KABUPATEN SOLOK
Authors: Welia Yenti , Witrianto Witrianto , Yulia Refni
Published: June 2021

Many efforts to improve the economy of the community, either by building it Rural Economy Business Multipurpose Cooperative (KSU-ED). Nagari Talang Babungo to improve the economy of the community and establish cooperative KSU-ED. After the founding of KSU-ED economy and the welfare of society is increasing, because the cooperative has helped to lend capital to improve the business community, and various efforts have been developed to improve the business community. KSU-ED Tabek have increasing from year to year, as evidenced by SHU (Business Profits) increasing so does the number of its members, and co-operatives are very active role in improving the local economy. The establishment of good cooperative impact people's lives, especially the members and its own management, its impacts, among others in the social and economic spheres of society.Berbagai upaya meningkatkan perekonomian masyarakat salah satunya dengan mendirikannya Koperasi Serba Usaha Ekonomi Desa (KSU-ED). Nagari Talang Babungo untuk meningkatkan perekonomian masyarakat dan koperasi mendirikan KSU-ED. Setelah berdirinya KSU-ED perekonomian dan kesejahteraan hidup masyarakat semakin meningkat, karena koperasi telah membantu meminjamkan modal untuk meningkatkan usaha masyarakat, dan berbagai macam usaha telah dikembangkan untuk meningkatkan usaha masyarakat. Perkembangan KSU-ED Tabek dari tahun ketahun semakin meningkat, terbukti dengan SHU (Sisa Hasil Usaha) yang semakin meningkat begitu juga dengan jumlah anggotanya, serta koperasi sangat berperan aktif dalam meningkatkan ekonomi masyarakat. Berdirinya koperasi membawa dampak baik bagi kehidupan masyarakat khususnya para anggota dan pengurusnya sendiri, dampak yang ditimbulkannya antara lain dalam bidang sosial dan ekonomi masyarakat.
BURUH TANI JEMPUTAN DI DESA SAKO DUA, KEC. KAYU ARO BARAT, KAB. KERINCI, JAMBI
Authors: Wijaya Wibi , Zusmelia Zusmelia , Elvawati Elvawati
Published: June 2021

Peasant pick up are peasant who do not work everyday but they are such kind of workers which is need to be called or picked up first for working. The purpose of this research is to see the factors causing the increase number of peasant pickup in community Sako Dua village Kayu Aro Barat  district Kerinci Jambi. This research used qualitative approach with descriptive type. The informant is call peasant lanor and the owner of the field. Informan choosing with purposive sampling. Data Collected through observation (non-participant) and deep interview. Based on the result of the research it can be conclude that the factors causing the increase number of peasant pickup in community Sako Dua village is caused by internal factors and external factor from the  peasant pickup themselves. Internal factors from peasant pickup such as 1).  Economic Condition, 2). PTPN 6 Kayu Aro Retire influence, 3). Do not have agricultural land, 4). Do not have capital for cultivation, 5). Limited Job opportunity in the village. External factors from peasant pickup such as 1). The occurance of Patron-klien relationship in society of Sako Dua village with the owner of fields, 2). Less of power in managing the land.Buruh tani jemputan merupakan buruh tani yang tidak bekerja setiap hari melainkan buruh yang harus dipanggil atau dijemput terlebih dahulu untuk bekerja. Penelitian ini  bertujuan untuk melihat faktor penyebab meningkatnya jumlah buruh tani jemputan dalam kehidupan masyarakat Desa Sako Dua Kecamatan Kayu Aro Barat Kabupaten Kerinci Jambi.Penelitian ini menggunakan pendekatan kualitatif dengan tipe deskriptif. Informan penelitian ini adalah buruh tani jemputan dan pemilik ladang. Pemilihan informan menggunakan teknik purposive sampling pengumpulan data dilakukan melalui observasi (non-participant), wawancara mendalam. Penelitian menunjukkan bahwa faktor penyebab meningkatnya jumlah buruh tani jemputan di Desa Sako Dua karena faktor internal dan eksternal dari buruh tani jemputan. Faktor internal dari buruh tani jemputan yaitu 1). Keadaan Ekonomi, 2). Pengaruh pensiunan PTPN 6 Kayu Aro, 3). Tidak memiliki lahan pertanian, 4). Tidak memiliki modal untuk mengolah lahan, 5). Terbatasnya lapangan pekerjaan di desa. Faktor eksternal dari buruh tani jemputan adalah 1). Munculnya hubungan patron-klien dalam masyarakat Desa Sako Dua dengan pemilik ladang, 2). Kurangnya tenaga dalam mengolah lahan.
KONFLIK PENGELOLAAN PARKIR LIAR DI PANTAI PURUS, KEC. PADANG BARAT, KOTA PADANG
Authors: Amril Ilmiati , Abbas Ardi , Prahara Surya
Published: June 2021

This article aim to describe the conflict of illegal parking management ini Purus beach, Padang.. Research conducted with qualitative approach through descriptive type. Informants selected with purposive sampling. Data collected throught partisipative observation, indeepth interview and study document. The result is illegal parking in Purus started since 2008 and growing in 2013. Conlict is between illegal parking attendants and the owner of the vehicle, where the vehicle owner loses something when parking, conflict is between illegal parking attendant and UPT parking in the process of demolition. Conflict resolution between between illegal parking attendant and the owner of the vehicle is throught conciliation and conflict resolution between UPT parking with illegal parking attendants thrught pursuing cooperation strategy  Penelitian ini bertujuan untuk mendeskripsikan konflik pengelolaan parkir liar di Purus Padang. Pendekatan yang digunakan dalam penelitian ini adalah kualitatif dengan tipe deskriptif analisis. Pemilihan informan mengggunakan teknik purpossive sampling. Metode yang digunakan untuk pengumpulan data dilakukan dengan cara observasi berperan serta terbatas, wawancara  mendalam (Indepth Interview) dan studi dokumen. Hasil penelitian menunjukkan bahwa munculnya parkir liar di Pantai Purus berawal semenjak jembatan penghubung dibangun pada tahun 2008 dan berkembang pada tahun 2013. Bentuk konflik yang terjadi dalam pengelolaan parkir liar adalah konflik antara petugas parkir liar dengan pemilik kendaraan, dimana pemilik kendaraan kehilangan barangnya disaat parkir, lalu konflik petugas parkir liar dengan UPT perparkiran dalam proses penertiban. Upaya penyelesaian konflik antara petugas parkir liar dengan pemilik kendaraan dengan cara konsiliasi dan upaya penyelesaian konflik petugas parkir liar dengan UPT Perparkiran dengan melakukan strategi kooperasi
Konflik Tanah Ulayat Antara Kaum Caniago Di Nagari Kasang Dengan Badan Pertanahan Nasional Padang Pariman
Authors: Fitlayeni Rinel
Published: June 2021

Communal land at the Minangkabau community identity and are protected by the Government contained in the UUPA. In defending existence, no wonder the increased intensity of conflict in society, even the biggest contributor in the court case is the problem of communal land. The conflict not only involve the public but also among the public with the state caused due to the interest of both parties . This paper wants to describe the conflict between members of the Caniago with BPN Padang Pariaman district. Conflicts involving both groups has occurred since 2002 and even up to now still continue.Tanah ulayat di Minangkabau merupakan identitas masyarakat  dan dilindungi keberadaannya oleh negara yang tertuang dalam UUPA. Dalam mempertahankan kebedaraannya, tidak heran terjadi peningkatan intensitas konflik di tengah masyarakat, bahkan penyumbang perkara terbesar di pengadilan adalah permasalahan tanah ulayat. Konflik yang terjadi bukan saja melibatkan antar masyarakat tetapi juga masyarakat dengan negara yang disebabkan karena faktor kepentingan kedua belah pihak.. Tulisan ini ingin mendeskripsikan konflik antara anggota kaum Caniago dengan BPN Kabupaten Padang Pariaman. Konflik yang melibatkan kedua belah kelompok sudah terjadi sejak tahun 2002 bahkan sampai sekarang.
Analisis Pemenuhan Hak Dasar Anak Pada Program “Kota Layak Anak” Di Kecamatan Gading Cempaka, Bengkulu
Authors: Himawati Ika Pasca , Nopianti Heni , Hartati Sri , Hanum Sri Handayani
Published: June 2021

The purpose of this research is to find and to analyzes the fulfillment of the basic rights on child based on the regulation of the state minister for women empowerment and child protection of the republic of Indonesia No. 12 of 2011 on indicators district of a city worthy of child. The research was done in 2 areas which is located in Gading Cempaka Subdistrict, they are in Cempaka Permai and Lingkar Baratvillage. Research conducted with qualitative approach and data was collected  throughout observation, interview , FGD and study document . The result is a). In the both of areas have not had children forum which can directly accommodate the aspirations of children and do not involve children (age category of teenagers) on the activities and deliberations or work programs that exist in the environment RT or RW. b). In the both of areas has not been in the region of the unavailability of two consulting agencies for parents/family and child welfare agencies. c). In the both of areas has not been in an optimum manner use of leisure time and cultural activities it was found problems yet the number of program activity level of RT and RW aimed at maximizing the potential of children, as well as the unavailability of Green Open Space (RTH) as playing area that is safe and comfortable for children. Tujuan penelitian ini ialah menemukenali serta menganalisis pemenuhan hak dasar pada anak yang didasarkan pada Peraturan Menteri Negara Pemberdayaan Perempuandan Perlindungan Anak Republik Indonesia No. 12 Tahun 2011 tentang Indikator Kabupaten Kota Layak Anak. Penelitian dilakukan di 2 kawasan yang berada di Kecamatan Gading Cempaka, yakni Kelurahan Cempaka Permai dan Kelurahan Lingkar Barat. Peneliti menggunakan pendekatan kualitatif dengan teknik pengambilan informan melalui purposive dan snowball sampling. Adapun teknik pengambilan data dilakukan  melalui observasi, wawancara, FGD dan studi dokumen. Temua penelitian menunjukkan bahwa a). Kedua wilayah penelitian belum memiliki forum anak yang dapat mengakomodir aspirasi anak secara langsung serta belum melibatkan anak khususnya anak kategori usia remaja pada kegiatan dan musyawarah ataupun program kerja yang ada di lingkungan RT/RW maupun kelurahan, b). Di dua kawasan tersebut belum tersedia lembaga konsultasi bagi orang tua/keluarga dan lembaga kesejahteraan anak. c). Belum banyaknya program kegiatan di tingkat RT dan RW yang ditujukan untuk memaksimalkan potensi anak serta belum tersedianya kawasan Ruang terbuka Hijau (RTH) sebagai kawasan bermain yang amandan nyaman bagi anak.
Back Matter Jurnal Ilmu Sosial Mamangan
Authors: Admin Admin
Published: June 2021

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Komunikasi Keluarga Dalam Pencegahan Perilaku Bullying Bagi Anak
Authors: Janitra Preciosa Alnashava , Prasanti Ditha
Published: June 2021

Communication process occurs in every aspect of life, including family. When people interact to each other, sometimes it may lead to bullying. Bullying is not a new phenomenon, especially in family. Bullying means verbal and physical threat, force and violence which conduct repeatedly, for instance by the older children to their younger sister or brother. This is the uniqueness of this research. Family communication becomes main foundation to prevent bullying. Researcher see this phenomenon as a unique problem to be studied. Based on that phenomenon, researcher interested to study “Family Communication in Preventing Bullying Behavior for Children”. Result shows that family communication in preventing children’s bullying behavior covers: (1) In order to prevent bullying, an effective family communication process has to be strived, including respect, empathy, audible (2) Causative factor of bullying is inappropriate parenting in context of family communication. Proses komunikasi berlangsung dalam setiap aspek kehidupan, termasuk dalam lapisan masyarakat dan lapisan keluarga. Ketika manusia melakukan interaksi satu sama lainnya, kadang-kadang mengarah pada perilaku bullying. Bullying bukanlah fenomena yang baru lagi, khususnya dalam sebuah keluarga. Bullying artinya ancaman, pemaksaan, kekerasan fisik maupun verbal yang dilakukan berulang-ulang, misalnya kakak kepada adiknya. Disinilah letak keunikan penelitian ini. Komunikasi keluarga menjadi pondasi utama untuk mencegah terjadinya perilaku bullying bagi anak. Peneliti melihat fenomena ini merupakan masalah yang unik dan menarik untuk diteliti. Berdasarkan fenomena tersebut, peneliti tertarik untuk mengangkat “Komunikasi Keluarga dalam Pencegahan Perilaku Bullying bagi Anak”. Hasil penelitian ini menunjukkan bahwa komunikasi keluarga dalam pencegahan perilaku bullying bagi anak meliputi: (1) Untuk mencegah bullying harus diupayakan proses komunikasi keluarga yang efektif yaitu: respek, empati, audible; (2) Adapun faktor penyebab terjadinya perilaku bullying adalah pengasuhan orangtua yang tidak tepat dalam konteks komunikasi keluarga
Beginner Voter’s Behavior: Study of the Simultaneous Regional Elections at Karawang Regency, West Java
Authors: Supriatna Encup
Published: June 2021

The purpose of this study is to know: Beginner Voter Behavior, the extent to which parties influence the political party influence the behavior of voter’s beginners, and factors that can affect voter behavior in Pedes Regency in the Simultaneous Regional Elections in Karawang regency in 2015. This study uses phenomenological approach, analytical descriptive method, and various qualitative research. The qualitative data needed in this research is related to: Beginner Voter Behavior, the extent to which parties influence the political parties to influence the behavior of the beginning voters, and what factors may affect voter behavior in Pedes District in the Simultaneous Regional Elections in Karawang regency in 2015 that is appropriate data and considered it is necessary to solve the problems formulated in the study. The analysis involves Beginner Voter Behavior, the extent to which political parties influence the behavior of novice voters, and factors that may influence voter behavior in Pedes District in the Simultaneous Regional Elections in Karawang Regency in 2015.
The Analysis of Local Potential in BUM Desa Empowering in Desa Lembengan, Kecamatan Ledokombo, East Java
Authors: Hastuti Dwi , Chilmy Nurwahdatul
Published: June 2021

This research examines to know empowerment effort by local government. It focuses on social capital in society and new local potentials. This study use descriptive qualitative research. This research uses some data collection techniques such as observation, in depth interview, and documentation. Data are conducted through stages such as (1) data reduction, (2) presentation of data, (3) conclusion. The results through these stages can be credible. Then data triangulation technique is used during validation. This research result shows that empowerment of BUM Desa still less successful. In progress and implementation, BUM Desa in Lembengan in 2010-2017 has not contributed to local governance income significantly. This research finds the weak role of social capital of society such as commitment, trust, norm, social network to support BUM Desa empowerment in Lembengan. There are some BUM Desa business partners as new local potential that can be developed such as brick industry, petulo cracker industry, and tobacco industry.
PARENT’S MOTIVATION IN FORMAL EDUCATION AT RESTRICTION AREA (Case Study in People of Keter Laut Island Regency of Bintan)
Authors: Miswanto Miswanto , Utari Diah Siti , Pramono Dwikhy Anindito
Published: June 2021

Education is a necessity for everyone. By education, people will clever and can solve both social and economy problems in their family. Because of that reason, parent’s involvement in children education can be interpreted as indicator how their perception about education. Most of people in Keter Laut Island have profession as fisherman which depend on yield of ocean’s catch. It makes parent sometime forget their duty as first agent of socialization in family and also forget right of the children. It a must for parent to make a life and be responsible to their family, not involve children to work, especially for whom need education and lesson at school. The goal of this research is to know how parent’s motivation in formal education for children in Keter Laut Island. The method of this research is descriptive qualitative, which use both of interpretative and naturalistic approach to the main study (Subject of Matter). The population of this research is parents who have children attend school. The sample is taken by Saturated Sampling technique. There are 20 people as the sample. From this research, all parents in Keter Laut Island want their children have a better education because by education, intelligence will improve and of course it will change people’s life in Keter Laut Island include their economy sector. Beside of that, parents also do not want their children have same destiny as their parents who have profession as a fisherman while their income just enough barely to live on.