bluuebunny/crossref_metadata_2025 huggingface dataset:
Bibliometric Analysis of Green Marketing Strategies: Innovative Approaches to Improve Sustainability
Authors: Saputra Apep Indra , Asfiah Nurul
Published: February 2025

Sustainability has become an urgent global issue, and green marketing emerges as a crucial strategy to support environmentally friendly business practices. This study aims to identify research trends in the field of green marketing through bibliometric analysis using the VOSviewer tool. The data used were sourced from Scopus-indexed publications between 2014 and 2024, with the main identified themes being green consumption development, environmental awareness, and green supply chain management. The findings indicate that although green marketing raises consumer awareness of eco-friendly products, there is a gap between purchase intentions and actual consumer behavior. This study also highlights the importance of clear information and effective communication to enhance loyalty to green brands. Additionally, collaboration among companies, consumers, and governments is essential to achieving broader sustainability in the context of green marketing and consumption.
Implementation of A Total Ergonomics Approach To Improve the Quality of Life of Freight Workers In 16 Ilir Market, Palembang City, South Sumatera Province
Authors: Setiawan Heri , Susanto Sani , Rinamurti Micheline , Pratama Yohanes Dicka
Published: February 2025

The results of preliminary observations of the working conditions and environment of freight workers in the 16 Ilir Market, Palembang City, South Sumaetera Province are categorized as less ergonomic in physical, work environment, psychological, organizational and management aspects. Freight workers work by placing baskets on their heads, on their backs and even some without tools directly on their shoulders which load basic food items, and loading-unloading warehousing goods, weighing ±35 kg, a distance of ±500 meters with a low level of productivity. After finishing work, freight workers experience aches all throughout the body, particularly in the legs and neck, as well as waist and back pain. Based on work pulse frequency, the workload was determined to be 131.25±14.10 beats per minute, and it was categorized as heavy work. The fatigue score reached 69.10±15.29 and the musculoskeletal disorder score was 61.25±7.44. The method used is a total ergonomics approach, to enhance work productivity by reducing workload, fatigue, and musculoskeletal system issues. Thirty research samples were chosen by simple randomization of freight workers for this same-subject experimental study. The Wilcoxon Signed Rank Test and the t-paired test were used to evaluate the data at a 5% significance level. Workload, weariness, and musculoskeletal complaints significantly decreased, and productivity increased (p<0.05), according to the data. In conclusion, the total ergonomics approach reduced workload as seen from the decrease in: work pulse rate by 15.61%, fatigue by 58.97%, musculoskeletal system complaints by 28.78%. Consequently, there was a 21.00% increase in productivity. The total ergonomics approach can improve the quality of life and work productivity of freight workers in 16 Ilir Market, Palembang City, South Sumatera Province
Memória, diáspora e identidade: para uma espécie de in-betweenness na obra poética "Do tempo suspenso" (1998) de Maria Alexandre Dáskalos
Authors: Yu Peilin
Published: February 2025

Como componente da chamada “geração das incertezas” (Kandjimbo, 2001) da literatura angolana, que engloba uma constelação poética distinta, incluindo nomes brilhantes como Paula Tavares, Ruy Duarte de Carvalho, Lopito Feijóo, etc., a voz poética de Maria Alexandre Dáskalos, embora relativamente menos destacada e analisada, contém uma sensibilidade exuberante, única e inovadora, que dialoga experimentalmente com vários elementos de diversas representações culturais, realizando uma contemplação reflexiva sobre os vários significados do tempo, do espaço, da história e da identidade. O pensamento da poeta angolana sobre as relações entrelaçadas entre o presente e o passado, entre a posição atual e a terra longínqua, e entre as diferentes referencialidades culturais e identitárias traduz-se em três tópicos fundamentais na sua obra Do Tempo Suspenso (1998): a memória, a diáspora e a identidade. Estas particularidades da poesia formam, no seu conjunto, um estilo de oscilação, movimento e pluralidade ou, em outras palavras, conforme Stuart Hall (1997), constituem um “play of difference within identity”. Tendo em conta o que foi referido, o presente artigo propõe uma leitura da obra Do Tempo Suspenso (1998) de Maria Alexandre Dáskalos a partir da perspetiva teórica do in-betweenness (Bhabha, 1994), com o objetivo de decifrar a construção dinâmica de uma determinada identidade africana na poesia, sempre enquadrada pelo contexto pós-colonial, pós-guerra e de diáspora, que não se pode desligar da posição peculiar do sujeito poético entre diferentes lugares de memória (Assmann, 2008), divergentes paisagens de humanidade e variadas terras geoculturais.
PERCEPÇÃO DOCENTE SOBRE EDUCAÇÃO AMBIENTAL CRÍTICA NAS ESCOLAS PÚBLICAS DA CIDADE DE GUZOLÂNDIA-SP
Authors: Vitória Alves Barbosa Micaela , Regina da Costa Aguiar Denise , Aparecida Regioli de Angelis Joslaine
Published: February 2025

Introdução: A Educação Ambiental em uma perspectiva crítica busca sensibilizar, conscientizar a
sociedade a respeito dos problemas ambientais e propor ações para superá-los. A Lei nº 9.795 de 1999
instituiu a Política Nacional de Educação Ambiental (PNEA). Objetivo: A pesquisa teve por objetivo
desenvolver uma investigação com professores de escolas públicas da cidade de Guzolândia-SP, na
expectativa de compreender qual a percepção desses profissionais em relação a importância da
Educação Ambiental na escola, assim como identificar as práticas pedagógicas que desenvolvem e
entender os possíveis desafios. Material e Métodos: A pesquisa desenvolveu- se por meio de uma
abordagem qualitativa e descritiva, com revisão bibliográfica e coleta de dados empíricos em forma
de questionário semiestruturado. Porse tratar de uma pesquisa que envolveu seres humanos, o projeto
foi submetido ao Comitê de ética em Pesquisa (CEP) e aprovado pela CAEE nº
69619023.5.0000.5494. Resultados e Discussão: Os professores trabalharam a Educação Ambiental,
em várias ações e propostas, no combate às doenças endêmicas, como o combate à dengue, em
projetos de jardinagem, com exploração de ecossistemas locais, discussões sobre a importância da
preservação ambiental, projetos sobre consumo e descarte correto de resíduos sólidos e de coleta
seletiva. Além disso, pode-se evidenciar como desafios à prática pedagógica, a falta de recursos
financeiros para o desenvolvimento dos projetos e a necessidade de oferta de formação contínua para
os professores, pela Secretaria de Educação, para o trabalho com as questões ambientais na escola.
Conclusão: Pode-se concluir que os professores apresentaram a concepção de Educação Ambiental
em uma perspectiva crítica, buscando conscientizar e sensibilizar os estudantes para as questões
ambientais, com ações de preservação ambiental, condição para o comprometimento,
responsabilidade e a participação de todos.
PENGEMBANGAN PRODUK SELAI BERBASIS PISANG AMBON (Musa paradisiaca S.) DAN UBI JALAR UNGU (Ipomea batatas L) : ANALISIS ANTIOKSIDAN, NILAI GIZI DAN ORGANOLEPTIK
Authors: Wa Ode Nurul Azizah Nida Ul Haq  , Yuyun Yuniati  , Kejora Handarini
Published: February 2025

Pisang dan ubi jalar ungu adalah bahan pangan kaya akan nutrisi yang mendukung kesehatan tubuh. Pisang  mengandung vitamin C, B6, kalium dan serat yang baik untuk pencernaan dan tekanan darah. Ubi jalar ungu mengandung  serat, vitamin A, C, mangan, serta antosianin, antioksidan yang kuat yang bermanfaat bagi kesehatan jantung, mata, dan  imunitas tubuh. Penelitian ini bertujuan untuk mengkaji pengaruh konsentrasi pisang dan ubi jalar ungu menggunakan  rancangan acak lengkap (RAL) dengan formulasi tersebut adalah: S1 (pisang 100%: ubi jalar ungu 0%), S2 (pisang 70%: ubi  jalar ungu 30%), S3 (pisang 60%: ubi jalar ungu 40%), S4 (pisang 50%: ubi jalar ungu 50%), S5 (pisang 40%: ubi jalar ungu  60%). Analisi meliputi uji serat, padatan terlarut, gula total, antioksidan serta uji organoleptik selai (warna, tekstur, rasa, aroma)  sesuai standar SNI 01-3746-2008 tentang selai. Data dianalisis menggunakan Analysis of Variance (ANOVA) untuk data parametrik dan uji kruskal wallis untuk data non-parametrik, dengan bantuan perangkat lunak SPSS
Tumores hepáticos
Authors: Frauca Remacha Esteban , García Vega Marta
Published: February 2025

La incidencia de los tumores hepáticos durante la infancia es baja. De entre los tumores benignos, el más frecuente es el hemangioma, mientras que el hepatoblastoma y el hepatocarcinoma son los tumores malignos más frecuentes. En la mayoría de los casos, se va a detectar el tumor tras una ecografía, bien tras palpación de una hepatomegalia o bien en el contexto de un examen rutinario. El hemangioma presenta un ciclo natural de crecimiento y posterior involución, por lo que el tratamiento solo está indicado en aquellos casos sintomáticos. En los casos de un hepatoblastoma o hepatocarcinoma, la curación de la enfermedad pasa por la resección completa del tumor y tratamiento con quimioterapia adyuvante. La supervivencia de los niños con tumores hepáticos, especialmente en el caso del hepatoblastoma, ha mejorado significativamente tras la introducción de pautas de quimioterapia efectivas y definición de estrategias quirúrgicas, incluyendo el trasplante hepático, apropiadas en cada caso.
Urbanization and architectural heritage preservation in Dar es Salaam
Authors: Faki Salim , Mbisso Daniel , Bahendwa Fortunatus
Published: February 2025

Dar es Salaam, the business hub in Tanzania, has witnessed rapid urbanisation in recent years due to several factors. Partly, urbanisation has taken place in isolation of preserving the city’s historic environment. The case study method was used in conducting this research in the central business district of Dar es Salaam, whereby information was gathered from government agencies, various stakeholders and local communities through interviews, observations, archives and online publications. This paper discusses integrating architectural heritage within contemporary urbanisation settings for more effective sustainability.
Leadership Style at the Contemporary Pesantren Al-Hilmu Prigen Pasuruan
Authors: Anasro Anasro , El-Yunusi Muhammad Yusron Maulana
Published: February 2025

Leadership style in Islamic boarding schools is often rooted in the charisma and independence of a leader known as Kiai, resulting in a predominantly authoritarian leadership style. This research aims to analyze the leadership style within Islamic boarding school institutions. The subject of this research is the Contemporary Islamic Boarding School Al-Hilmu in Prigen, Pasuruan. The research method employed is qualitative descriptive, focusing on 1) the tendencies of leadership styles in boarding schools and several aspects contributing to these styles. Data collection methods include observation, interviews, and documentation, while data analysis involves data reduction, data display, and conclusion drawing. The research findings conclude that 1) Based on the study of power source utilization, leadership behavior, and decision-making, it is concluded that the leadership style in the contemporary Islamic boarding school Al-Hilmu Prigen Pasuruan predominantly emphasizes a democratic leadership style. 2) Several factors contributing directly to the democratic leadership style in Al-Hilmu Prigen Pasuruan include a) vision and mission factors, b) characteristics and strengths of the boarding school, and c) educational levels (ability factor).
The Evolution of Pesantren Education: Continuity and Change in Curriculum and Management amid Modernization
Authors: Mas'udi Ahmad Thoyib
Published: February 2025

Pesantren, Indonesia’s oldest Islamic educational institutions, have played a significant role in religious, social, and intellectual life for centuries. However, modernization and globalization have challenged their traditional frameworks. This study examines the evolution of pesantren education, focusing on continuity and change in curriculum and management while analyzing how pesantren adapt to contemporary demands without compromising their core values. Using a qualitative approach, the research employs historical analysis and field observations based on primary and secondary data. The findings reveal that pesantren have retained their emphasis on kitab kuning while integrating general and vocational subjects since the mid-20th century. Management practices have also shifted from centralized, kiai-led models to more participatory approaches. These changes are driven by community demands, government policies, and technological advancements. Although limited to a specific subset of pesantren, this study highlights their ability to balance tradition and innovation, demonstrating their potential as dynamic institutions capable of addressing contemporary educational and societal challenges.
Pesantren and Environmental-based Educational Innovation: Building Environmentally Friendly Pesantren
Authors: Yusuf M.
Published: February 2025

This study explores the application of environmental-based educational innovation in Islamic boarding schools (pesantren) to build environmentally friendly pesantren. The main focus of this study is the involvement of pesantren in environmental conservation, which is still limited even though Islamic teachings firmly support the values ​​of ecological sustainability. This study uses a qualitative literature study method to analyze literature related to Islamic boarding schools, environmental education, and sustainability strategies in the context of Islamic educational institutions. The main findings reveal that pesantren have significant potential to become agents of change in environmentally-based education. Several pesantren have begun implementing environmentally friendly programs, but various challenges must be faced, including limited resources, infrastructure, and resistance to innovation. This study has essential value because it provides a model of educational innovation that integrates Islamic teachings with sustainability principles and is relevant to increasingly pressing global environmental challenges. Thus, this study strengthens the environmentally friendly Islamic education paradigm, which aligns with international efforts to address climate change.
Kiai Kampung and Transformational Leadership: A Model for Non-formal Education to Improve Community Quality of Life
Authors: Suhermanto Suhermanto , Jasri Moh.
Published: February 2025

This study aims to analyze the role of transformational leadership of village religious leaders (Kiai Kampung) in developing non-formal education and improving the community's quality of life. The research was conducted in Sumberrejo Village, Paiton District, Probolinggo Regency, East Java Province, focusing on five kiai who are prominent figures in the village. A qualitative approach with a case study method was employed. Data were collected through interviews, observations, and documentation, which were then analyzed through data collection, data reduction, data presentation, and conclusion. The study's results indicate that the transformational leadership applied by the Kiai Kampung in Sumberrejo Village is a driving force to achieve organizational goals and enhance the community's quality of life. The kiai utilizes four key characteristics of transformational leadership: (1) Idealized Influence/Charisma, (2) Intellectual Stimulation, (3) Individualized Consideration, and (4) Inspirational Motivation. Their leadership directs the development of community knowledge, with the kiai playing an active role in motivating, guiding, and inspiring individuals to achieve shared goals and visions. Direct involvement and close interaction between the kiai and the community significantly support achieving these goals. Through leadership based on close social interactions and continuous development, the quality of life in Sumberrejo Village, particularly in education and social empowerment, has experienced significant improvement. This study demonstrates that kiai kampung leadership can be a key factor in community empowerment at the local level.
Implementing project-based learning to enhance communicative skills in 4th grade students with autism in Cotopaxi province
Authors: Coello Jiménez Hugo Fabrizio , Collaguazo Potosí Alicia Magdalena , Sánchez Vargas Araceli Margoth , Riera Hermida Fernando Patricio
Published: February 2025

This research was conducted in a public school in the province of Cotopaxi, Ecuador. The main objective was to explore how project-based learning could improve communication skills in autistic students in 4th grade of primary school. The participants were a group of students aged 7 to 8 years, where there were two students with autism spectrum disorder. Project-based learning was a fundamental aspect during this teaching process because it allowed the students to improve interaction with their peers and with the English teacher. The students' English level proficiency was pre-A1 according to the results of the diagnostic test carried out at the beginning of the school term. Data were collected through the observation as a qualitative instrument and pre-test, post-test, and rubric as a quantitative instrument. As a final result, the data showed that autistic participants improved their communication skills from 0.70 at the beginning of the study and after the implementation of the project they finished with 2.69 on a scale of 1 to 5, demonstrating that project-based learning has the potential to develop the communicative skills.
Utilizing Eco-Innovation Practices to Mitigate Urban Soils Contamination from Heavy Metals: A Land Use-Based Sampling Study in Ijebu Ode, Nigeria
Authors:   National Centre for Technology Management, Ile-Ife, Nigeria., Amiolemen Sunday , Adenekan Olapeju
Published: February 2025

This study investigates the utilization of Eco-Innovation practices within Nigerian
industries to mitigate urban soil contamination. Soil samples were collected from
various urban land uses in Ijebu Ode town, specifically mechanic workshops (MW),
roadsides (RD), industrial areas (IL), and market zones (MT). Ten composite soil
samples were randomly gathered from each land use at a depth of 0-30cm and subjected
to analysis for heavy metal concentrations (copper Cu, iron Fe, lead Pb, zinc Zn,
cadmium Cd, manganese Mn) using an Atomic Absorption Spectrophotometer. This
facilitated the calculation of contamination levels and pollution load index. The
findings indicate that the concentration of Cu, Zn, Fe, and Mn is highest in soils from
mechanic workshops, with the degree of soil contamination ranking as follows:
Mechanic Workshop > Industrial land use > Roadside > Market land use. The study
concludes that elevated levels of heavy metals in the sampled urban soil are closely
linked to improper land use practices and other human activities. It advocates for the
promotion of sustainable environmental practices through comprehensive stakeholder
engagement aimed at educating the populace on the management and preservation of
urban soils against harmful practices.
Pemanfaatan Teknologi Telemedicine untuk Peningkatan Diagnosis Pneumonia Anak di Daerah Terpencil
Authors: Atnang Muhammad , Samsidar  , Mustamin Syaiful Bachri
Published: February 2025

Perkembangan teknologi  dewasa ini yang dibarengi oleh keberanian tenaga kesehatan komunitas bersatu untuk menaklukkan tantangan kesehatan global. Penelitian terbaru membuka tabir bagaimana telehealth bukan lagi sekadar angan-angan, melainkan solusi nyata untuk pendidikan medis yang merata. Dengan video konferensi dan program seperti Project ECHO, pelatihan berkualitas kini menjangkau para pahlawan medis di pelosok negeri, menghilangkan batasan geografis. Lebih dari itu, tenaga kesehatan komunitas (CLHW) tampil sebagai pejuang garis depan dalam perang melawan pneumonia. Mereka tidak hanya cakap memberikan amoksisilin oral, tetapi juga terampil menggunakan pulse oximetry, memastikan setiap anak dan bayi mendapatkan penanganan yang tepat waktu. Ini bukan lagi sekadar teori, melainkan bukti nyata bahwa perawatan kesehatan bisa diakses bahkan di daerah terpencil. Namun, ada raksasa ekonomi yang harus kita hadapi, yaitu biaya rawat inap pneumonia yang mencengangkan. Data di Inggris menunjukkan angka £731 juta per tahun, dan ini mungkin baru puncak gunung es. Di sisi lain, secercah harapan muncul dari Yordania, di mana masyarakat semakin menerima telemedicine, terutama mereka yang berpendidikan dan melek teknologi. Ini adalah panggilan bagi kita untuk memanfaatkan teknologi sebagai jembatan menuju layanan kesehatan yang lebih adil dan terjangkau. Temuan ini bukan hanya data, melainkan inspirasi untuk perubahan yang lebih baik.
Avanços na Revascularização Coronária Stents Bioabsorvíveis e Abordagens Minimamente Invasivas: Revisão Sistemática
Authors: Clara Sertão Alves Ana , Quintella de Moura Júnior Ary , Gonçalves Sousa Beatriz , Benevides Antunes Bruna , Lacerda Bandeira de Sousa Bruna , Dourado Prado Camila , Bittencourt Castro Vieira Cecília , Silva D’Angelo Gabriela , Ottoni Lelo Cossette Pedro , Diniz Gonçalves Igor , Benevides Nascimento Laura , Brito Gonçalves Lavínia , Medrado Silva Lucas , Ryan Araújo de Novaes Marcio , Fernanda de Bastos Bonadiman Maria , Vânia Oliveira Cardoso Uendes
Published: February 2025

Os avanços na revascularização coronária, especialmente com o uso de stents bioabsorvíveis e abordagens minimamente invasivas, representam uma evolução significativa na cardiologia intervencionista. Este estudo tem como objetivo revisar os benefícios clínicos dessas tecnologias, avaliando sua eficácia e impacto nos desfechos dos pacientes. A metodologia baseou-se em uma revisão integrativa da literatura, analisando estudos recentes sobre o tema. Os resultados indicam que os stents bioabsorvíveis reduzem complicações a longo prazo, como a trombose tardia, e promovem uma melhor preservação da função vascular. Além disso, as técnicas minimamente invasivas demonstraram menor tempo de internação e recuperação mais rápida, garantindo maior conforto e segurança ao paciente. A discussão comparou os achados com a literatura existente, ressaltando as limitações do estudo e perspectivas futuras. Conclui-se que essas inovações oferecem alternativas promissoras na revascularização coronária, embora sejam necessários mais estudos para avaliar sua aplicabilidade a longo prazo.
Mecanismos neurobiológicos da Depressão: implicações para diagnóstico e tratamento
Authors: Cajé Nunes Bianca , Spanier Vinicius , Varjão Silva Camacho Leonardo , Viana Dias Nathália , Luiza Barbosa Rodrigues Maria , Werli Andreza
Published: February 2025

O estudo atual oferece uma avaliação metódica dos fundamentos neurobiológicos da depressão, enfatizando a natureza intrincada e multifatorial desse transtorno psiquiátrico. A investigação reúne insights de diversos domínios, incluindo genética, psicologia e bioquímica, para esclarecer alterações nos níveis de neurotransmissores, como serotonina, dopamina e noradrenalina, juntamente com modificações na neuroplasticidade e desregulação do eixo hipotálamo-hipófise-adrenal (HPA). A abordagem empregada abrangeu uma busca exaustiva de bancos de dados, aderindo a rigorosos critérios de elegibilidade, culminando em uma síntese meticulosa das evidências existentes. As conclusões articuladas neste estudo sugerem que a depressão deve ser conceituada como um transtorno complexo que requer uma abordagem holística no diagnóstico e na intervenção, levando em consideração fatores biológicos e psicossociais, bem como estratégias terapêuticas multimodais.
Global Warming and Plant Fluctuation: Untangling Complex Environmental Interactions
Authors:   Department of Life Sciences, Khwaja Fareed University of Engineering and Information Technology, Rahim Yar Khan, Pakistan, Sameen Saira , Shah Kausar , Khalil Iqra , Khalil Bilal ,   Institute of Botany, Bahauddin Zakariya University, Multan, Pakistan
Published: February 2025

This complete analysis investigates the deep courting between global warming and plant changes, focusing on the complex environmental interactions that impact plant productivity and atmosphere sustainability. The paper investigates various aspects of climate change’s consequences on flowers, such as rising temperatures, phenological shifts, drought pressure, accelerated carbon dioxide ranges, soil microbiome changes, intense climate activities, invasive species proliferation, and pollinator-plant interactions. It makes a specialty of the adaptive techniques used by flowers in reaction to environmental limitations, consisting of migration, physiological modifications, and genetic adaptations. The evaluation underlines the significance of multi-omics approaches to information plant responses to abiotic stresses, in addition to the consequences of global warming on biodiversity and ecosystem resilience. Moreover, it reflects the altered role of soil microorganisms, which ultimately affects plant nutrition and operational risk due to climate change. The paper additionally examines the effects of severe weather occasions on plant survival and agricultural production, in addition to the complex interaction among invasive species and native ecosystems under altering climatic conditions. Through the integration of recent research work and pinpointing information deficiencies, this paper offers precious insights for growing evidence-based total policies and sustainable land control practices. It underscores the need for endured research and interdisciplinary collaboration to beautify our expertise in plant-climate interactions and to develop powerful techniques for maintaining plant productiveness and environmental health in the face of global climate disruption.
Integrating Multi-Omics Data for Plant Stress Response: Current Advances and Future Directions
Authors:   Freelance writer, Mumbai, India, Kajrolkar Amita
Published: February 2025

The growth along with productiveness of plants undergoes influence from multiple abiotic and biotic stress factors. The collection of multi-omics approaches combines genomic data with RNA sequences together with protein and metabolic data to create an all-encompassing knowledge system about plant stress responsiveness. Progress in sequencing technology and mass spectrometry and computational techniques makes it possible to identify genes along with proteins and metabolites and regulatory networks in response to stress. The obtained knowledge helps develop marker-assisted selection together with metabolic engineering and precision agriculture techniques for crop improvement. The combination of single-cell and spatial omics and stress memory studies with microbiome interaction research presents great potential to boost plant resistance while sustaining agricultural practices.
Mpox Outbreak: Impact and Public Health Response
Authors:   Independent Public Health Researcher, Lagos, Nigeria, Ekuri Susan
Published: February 2025

The re-emergence of mpox as a global public health threat has once again brought the viral disease to the attention of the international community. As mpox cases increase and spread beyond the shores of Africa, public health experts face the challenge of implementing effective measures to contain the disease. This review aims to examine the significance of mpox in public health, with a particular focus on recent outbreaks and understanding the public health response. The review explores recent approaches, including vaccination strategies, risk communication, and emergency preparedness. The paper also critically analyses limitations and offers possible future directions for improving the management of current and future outbreaks. Google and Google Scholar search engines as well as PubMed database were searched to identify literature concerning mpox public health impact and response. Websites of the WHO and similar organizations were also searched. The key search terms used were ‘‘mpox,’’ ‘‘public health,’’ ‘‘impact,’’ ‘‘response,’’ and ‘‘outbreak.’’ The review findings highlighted the challenges and gaps in the ongoing mpox outbreak response, ranging from vaccine shortage to limited surveillance and testing capacity and infrastructure, as well as inequitable access to vaccines and medical countermeasures. Other challenges include logistical issues and ongoing conflicts. This article emphasized the urgent need for multi-sectoral collaboration among key stakeholders, including embracing a One Health approach in case detection and investigation. The prevention and control of mpox require a more effective response that prioritizes rapid and equitable access to vaccines, diagnostics, and other necessary countermeasures.
CRISPR-Cas9 Gene Editing for Targeting Cancer Stem Cells in Glioblastoma Multiforme
Authors: Saifullah Khan Mahar  , Amara  , Ammara Ali  , Amina Javid  , Bilal Khan
Published: February 2025

This research investigates the possibility of CRISPR-Cas9 gene editing in targeting glioblastoma multiforme (GBM) cancer stem cells (CSCs) for increasing CSC sensitivity to conventional treatments and suppressing tumor growth. A quantitative method was used, with a sample of 36 GBM patients diagnosed and treated at major tertiary care centers in Pakistan, namely Aga Khan University Hospital (Karachi), Shaukat Khanum Memorial Cancer Hospital (Lahore), and Pakistan Institute of Medical Sciences (Islamabad). Tumor tissue samples were obtained at the time of surgical resection and processed to harvest CSCs based on certain markers like CD133 and Nestin using fluorescence-activated cell sorting (FACS). The CRISPR-Cas9 gene editing was subsequently conducted on isolated CSCs to knock out genes of interest involved in stemness and therapy resistance, such as SOX2, MGMT, and Wnt/β-catenin. The efficacy of CRISPR-Cas9 gene editing was evaluated by pre- and post-CRISPR tumor growth rates, proliferation assays in vitro, and neurosphere formation. Multiple regression analysis showed that CRISPR-Cas9 gene editing greatly enhanced therapy sensitivity (B = 1.427, p = 0.000), with pre-CRISPR tumor growth rate (B = -0.512, p = 0.009) and initial tumor size (B = -0.312, p = 0.040) having a negative correlation with the efficacy of treatment. Moreover, increased MGMT expression (B = -0.312, p = 0.050) was related to decreased therapy sensitivity. ANOVA test showed significant variability among the efficacies of different delivery methods for CRISPR-Cas9, including viral vectors, nanoparticles, and electroporation (F = 4.56, p = 0.008), and pointed towards optimizing the delivery strategies to achieve efficient gene editing. CRISPR-Cas9 shows promise for GBM treatment, but delivery issues and off-target effects need resolution to enable future clinical applications.
Acquired Immunodeficiency Syndrome in Hemophilia A: A Case Report and Literature Review
Authors:   Optum Infusion Services, Dang Karp Vy , Kim Eunjung , Schrade Lisa , Thaker-Mehta Nidhi
Published: February 2025

Background
Hemophilia is an X-linked recessive coagulation disorder which is characterized by factor VIII deficiency. Hemophilia A is the most common inherited bleeding disorder, accounting for up to 85% of the hemophilia population worldwide. The association between hemophilia A and acquired HIV/AIDS is infrequently seen in practice nowadays. We present a rare case of congenital hemophilia A with acquired HIV/AIDS due to contaminated plasma products during the HIV epidemic between the 1980s and 1990s.

Case Presentation
We report a case of a 50-year-old male with a complicated medical history of moderate to severe congenital hemophilia A, immune thrombocytopenia, multiple episodes of upper gastrointestinal (GI) bleeding, target joint bleeding, arthritis, and acquired HIV/AIDS. The prolonged partial thromboplastin time (PTT) of 32.5 secs and baseline FVIII of 0-3% confirmed the diagnosis of hemophilia A. Medical records revealed the patient was treated with cryoprecipitate and factor concentrates for hemophilia in early childhood. Aggressive HIV/AIDS regimens were given along with long-term antibiotics for opportunistic infections. A literature review was performed to identify similar unique cases of this rare association.

Conclusion
Acquired HIV/AIDS present in hemophilia A patients is not commonly seen in practice. The plasma contamination tragedy enforced stringent regulations and guidelines on the manufacturing industry. Remarkably, hemophilia patients can now achieve a longer lifespan and quality of life through novel hemophilia treatment.

Keywords: Hemophilia A, AIDS/HIV, Factor VIII activity, Contaminated plasma products.
Non-Suicidal Self-Injury in Child and Adolescent Psychiatric Inpatients: Clinical Correlates and Hematological Findings
Authors: Okuyucu Merve , Tural Hesapçıoğlu Selma , Ceylan Mehmet , Hacıosmanoğlu Cafer Doğan , Kanoğlu Yüksekkaya Seda
Published: February 2025

Objective: Non-suicidal self-injury (NSSI) is a prevalent concern in child and adolescent psychiatry, often serving as a maladaptive coping mechanism. Despite its frequent occurrence in psychiatric inpatient settings, limited research has examined its clinical and biological correlates, particularly hematological parameters. This study investigates the prevalence of NSSI, its psychiatric and sociodemographic associations, and hematological parameters in a psychiatric inpatient population. Method: This study included psychiatric inpatients aged 10–18 years. Psychiatric evaluations were conducted using the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL-DSM-5). Participants were classified into NSSI and non-NSSI groups.. Results: NSSI was observed among hospitalized adolescents, with self-cutting as the most frequent method. The primary motivations were distress (63.9%) and coping with difficulties (13.9%). Adolescents with NSSI had higher rates of sexual abuse exposure (p = 0.0001) and suicide attempts (p < 0.0001). depressive disorder was the most common diagnosis (p = 0.03), with 70.2% of NSSI individuals having at least one comorbid psychiatric disorder. Hematological analyses showed significantly lower ferritin levels in the NSSI group (p = 0.01), while other markers did not differ. Logistic regression identified sexual abuse exposure, suicidal behavior, and low ferritin levels as predictors of NSSI. Discussion: NSSI is highly prevalent among psychiatric inpatients and is strongly associated with sexual abuse history, psychiatric comorbidities, and low ferritin levels. Screening for abuse history, suicidality, and iron metabolism disturbances may enhance risk assessment. Future research should explore the mechanistic role of iron metabolism in NSSI.
A Study on Environmental Concern, Attitude and Sustainability-Driven Entrepreneurial Intentions
Authors: Goswami Swati ,   Hemwati Nandan Bahuguna Garhwal University, Srinagar, Kohli Pooja ,   Hemwati Nandan Bahuguna Garhwal University, Srinagar, Pokhriyal Ashok Kumar ,   Hemwati Nandan Bahuguna Garhwal University, Srinagar
Published: February 2025

The present research aims to examine the role of environmental concern (EC) in developing university students’ Sustainability-driven entrepreneurial intention (SDEI). This investigation also analyses the influence of EC on Attitudes toward sustainable entrepreneurship(ASE) and the effect of ASE on SDEI. The study gathered cross-sectional data from MBA and B. Tech final-year students of HNB Garhwal University and Uttaranchal University of Uttarakhand, India. Convenience sampling was used to gather 158 responses in total. Further, correlation and bivariate regression were employed to test the proposed hypotheses with SPSS version 26. The outcomes revealed a statistically significant association between all the relationships; however, a very low positive correlation was discovered between EC and SDEI. Moreover, the correlation between EC and ASE was also low positive. Only the correlation between ASE and the SDEI was highly positive. The study inferred that university students of Uttarakhand were aware of environmental issues and had concerns about them and their impact on human wellbeing but were hesitant to take entrepreneurial action. The research recommends an appreciable level of positive EC to establish students’ strong attitudes and intentions for sustainable ventures.
Diagnosis of mycotic skin infections and principles of antimycotic therapy
Authors:   University of Pécs Medical School Department of Dermatology, Venereology and Oncodermatology, Keresztes Dorottya , Marx Eszter , Szebényi Júlia , Hanyecz Anita , Gyulai Rolland , Lengyel Zsuzsanna , Szlávicz Eszter
Published: February 2025

A wide range of topical and systemic products are now
available for the treatment of mycotic skin infections. T he
choice of an appropriate therapy requires reliable microbiological diagnostics and knowledge of the exact mechanism of action and side effects of antimycotics. Risk-benefit considerations are important in the choice of therapy,
including the patient’s co-morbidities and the medication
used, as well as compliance. If all these issues are carefully considered, and antimicrobials are used at the correct dose and for the proper duration, infection treatment
can be successful. However, the modification of virulence
factors and the increasing antifungal resistance may be a
challenge for the practitioner.
Phaeohyphomycosis in an immunocompromised patient
Authors:   Semmelweis University, Faculty of Medicine Department of Dermatology Venereology and Dermatooncology, Anker Pálma , Medvecz Márta , Mihalik Noémi , Sinkó János , Sax Balázs , Ostorházi Eszter , Holló Péter
Published: February 2025

Phaeohyphomycosis comprises a rare group of fungal infections caused by pigmented filamentous (mold) fungi, caused
by various species. The most common manifestations of subcutaneous infection include subcutaneous nodules, abscesses, and cysts. The authors present the case of a 52-year-old
patient, immunosuppressed due to heart transplantation,
who developed subcutaneous erythematous, livid nodules
on both legs. During histological examination, in addition
to extensive dermal lobular infiltration, PAS reaction-positive septated fungal elements were visible. During repeated
histological sampling and culture Curvularia infection was
confirmed. The plant spike detected in the second biopsy
supported the fact of traumatic inoculation. The skin signs
resolved after 4 months of voriconazole therapy.
Differential diagnosis of multiple Café-au-lait macules in the context of clinical presentation and genetic background
Authors:   Heim Pál National Institute of Pediatrics Department of Dermatology, Veres Klára , Nagy Benedek , Ember Zsófia , Fodor Annamária , Szabó László , Szalai Zsuzsanna Zsófia
Published: February 2025

Café-au-lait macules (CALMs) are common hyperpigmented macules that can present in solitary or multiple
forms. Approximately 2-3% of healthy newborns are
affected by café-au-lait spots; however, their multiplex
appearance may indicate an underlying genetic syndrome.
The authors provide a comprehensive overview of the
differential diagnosis of café-au-lait macules (CALMs) and
their associated conditions, including the clinical features
and genetic background of each syndrome. Among the
discussed conditions are RASopathies, including neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2),
Legius syndrome, Noonan syndrome, Noonan syndrome
with multiple lentigines (LEOPARD syndrome), Costello
syndrome, and Watson syndrome. Furthermore, the review
includes phakomatoses such as tuberous sclerosis and
McCune-Albright syndrome, alongside constitutional mismatch repair deficiency syndrome (CMMRD) and other
syndromes that exhibit a weaker association with CALMs.
The publication emphasizes the importance of a multidisciplinary approach for patients presenting with multiple CALMs, as well as highlights the significance of early
diagnosis and genetic counseling for establishing an appropriate therapeutic plan and improving prognosis.
Unilateral facial oedema accompanied with multiple cutaneous symptoms caused by Lyme borreliosis; short introduction to the current national diagnostic and therapeutic guideline of the disease
Authors:   University of Debrecen Medical Center Department of Dermatology, Steuer-Hajdu Krisztina , Szegedi Andrea , Gáspár Krisztián
Published: February 2025

The authors present the case of a 74-year-old female patient who developed a reddish-brown nodule on her neck
and a purplish-red swelling on her left earlobe, accompanied with sudden onset of unilateral facial oedema. Biopsy
and serological tests confirmed borrelia lymphocytoma.
The patient fully recovered after amoxicillin therapy. In
connection with the case report authors also summarize
the recent, available diagnostic and therapeutic options
for skin Lyme borreliosis.
Generalised oedematosus, haemorrhagic rashes: severe disease or benign condition?
Authors:   Heim Pál National Institute of Pediatrics Department of Dermatology, Budapes, Nemesánszky Zsuzsanna , Veres Klára , Fodor Annamária , Schveibert Ágnes , Tari Zsófia , Szalai Zsuzsanna Zsófia
Published: February 2025

Acute haemorrhagic edema of infancy is a less-known,
probably underdiagnosed condition. Despite of the rapidly
evolving, haemorrhagic skin symptoms and the edema affecting multiple bodyparts, the disease is self-heeling and
benign. Being aware of it is essential for preventing unnecessary diagnostic measures and inadequate therapies.
In the majority of cases, this illness doesn’t require hospitalisation or only a short period of observation is needed
to exclude any differential-diagnostic illnesses. It is a self
limiting condition, that heels without residual symptoms.
In this publication 5 cases of acute haemorrhagic edema
of infancy are presented. In addition, differential diagnostics and diagnostic criterias are described.
Therapy of severe acne: treatment results of five years at the Department of Dermatology and Allergology, University of Szeged
Authors:   University of Szeged Albert Szent-Györgyi Medical Center Department of Dermatology and Allergology, Tajti Zsanett , Kemény Lajos , Gyulai Rolland Péter , Csoma Zsanett Renáta
Published: February 2025

Acne conglobata and acne fulminans are rare, but very
severe types of acne disease. These serious inflammatory
skin disorders usually affect the adolescent and the young
adult population. The early introduction of the efficient
therapy is pivotal in order to prevent the development of
severe scar formation. A retrospective study was performed
between 2017 and 2021 in the Paediatric Outpatient
Clinic of the Department of Dermatology and Allergology,
University of Szeged. Demographic (age and gender) and
clinical data (severity and extension of acne, duration
of the inflammatory lesions, types of local and systemic
therapies, duration of medical therapies and comorbidities)
of the patients with acne conclobata or acne fuminans were
analysed. Acne conglobata was diagnosed in 67, and acne
fulminans in 2 patients during the study period. The mean
age of the patients was 15,7 years, with a male predominance.
Systemic therapy was introduced in 84% of the adolescents
(n=58); 55 patients (80%) received isotretinoin therapy, oral
corticosteroid treatment was necessary in 14 subjects (20%).
Patients have received systemic treatment for 16 months on
average; duration of corticosteroid therapy was 10,6 weeks
and the period of isotretinoin therapy was 11,6 months
on average. Follow-up visits were performed in every 2-3
weeks at the beginning of the therapy, and in every month
during maintenance treatment. In acne conglobata and
acne fulminans recommended treatment is oral isotretinoin
often combined initially with oral corticosteroids. In more
severe cases exacerbation of inflammatory symptoms can
be observed after completion of retinoid therapy, and in
these patients duration of treatment takes usually longer.
Colitis ulcerosa and obesity can be associated with more
severe forms of acne conglobata.
Forum non-convenience as a basis for determination of jurisdiction
Authors: Čolović Vladimir , Crnjanski Vladimir
Published: February 2025

The institution of forum non conveniens as a base for determining jurisdiction in special situations is a doctrine of the Anglo-Saxon legal system. This doctrine allows the court to assess whether it is better to continue the proceedings or if it is more efficient to leave the jurisdiction for the given case to the court of another country. The court will make the said decision, only if it determines that it is “more appropriate” to conduct the proceedings before another court. This doctrine is not known in the continental legal system. However, given the fact that a legal relationship with a foreign element consists of several facts, the question can be raised as to whether it is more or less “connected” to the judiciary of a domestic or foreign country. The paper defines the concurrent jurisdiction of the courts, which is the basis for the application of the doctrine of forum non conveniens, and this institute is analyzed in relation to lis pendens, as well as the deviation clause. In the work, the authors pays attention to the application of the Brussels Convention on Jurisdiction and the Recognition and Enforcement of Court Decisions in Civil and Commercial Matters, as well as the Brussels and Brussels Ia Regulations, which replaced the aforementioned Convention and abolished the application of forum non conveniens in Great Britain until its exit from the EU. Finally, the authors analyzes the possibility of applying the doctrine of forum non conveniens in the continental legal system, and therefore its place in the legislative system of the Republic of Serbia.
The histoire d'une ideée – la société civile européenne: with the référnce particulière à la theory de Jürgen Habermas
Authors: Ćeranić Perišić Jelena
Published: February 2025

L’idée de société civile puise son origine des démocraties de l’Antiquité. Le contenu de la notion était à plusieurs reprises altéré, à mesure que les époques historiques changeaient. Après la Seconde Guerre mondiale, l’Europe a réalisé l’importance de mobiliser les forces vives des nations pour s’engager dans les grands programmes de reconstruction et de réforme. Selon les idéologues de l’époque, la construction européenne ne pourrait se renforcer que si elle s’appuie sur un mouvement social fort, ancré dans les territoires et agissant au-delà des frontières. Pour illustrer l’évolution de l’idée de la société civile européenne, nous allons tout d’abord examiner les origines du concept de société civile, notamment à travers la philosophie de Jürgen Habermas. Dans un deuxième temps, nous allons évaluer l’enjeu de la société civile dans le processus de l’intégration européenne qui lui est conférée par le traité établissant une Constitution pour l’Europe bien qu’il ne soit jamais entré en vigueur. Même si le traité de Lisbonne a repris la plupart des solutions prévues par le traité établissant une Constitution pour l’Europe, les dispositions relatives à la société civile n’ont été accepté que par fragment.
Piercing the Corporate Veil
Authors: Pušac Jovana
Published: February 2025

The subject of the research is the institute of commercial law, which is in the service of protecting the creditors of those companies whose members are liable up to the amount invested. We are talking about a kind of legal phenomenon called “piercing the corporate veil” or, as the legislator calls it, “abuse of legal entity” which, although it was legitimized three decades ago, is insufficiently processed in our legal theory, and only exceptionally applied in judicial practice, despite the fact that it is often the only means of protecting creditors against unscrupulous debtors. The decisive evidence in such disputes is financial forensic expertise. Aware that the scientific treatment of this institute will not automatically lead to its more frequent application, the author believes that it will still contribute to the raising of legal awareness, like Paracelsus’ saying: “The more knowledge is inherent in a thing, the greater the love” ... because power is in knowledge.