bluuebunny/crossref_metadata_2025 huggingface dataset:
Pediatric, Adolescent, and Young Adult Thyroid Carcinoma Harbors Frequent and Diverse Targetable Genomic Alterations, Including Kinase Fusions
Authors: Vanden Borre Pierre , Schrock Alexa B. , Anderson Peter M. , Morris John C. , Heilmann Andreas M. , Holmes Oliver , Wang Kai , Johnson Adrienne , Waguespack Steven G. , Ou Sai-Hong Ignatius , Khan Saad , Fung Kar-Ming , Stephens Philip J. , Erlich Rachel L. , Miller Vincent A. , Ross Jeffrey S. , Ali Siraj M.
Published: February 2017

Background

Thyroid carcinoma, which is rare in pediatric patients (age 0–18 years) but more common in adolescent and young adult (AYA) patients (age 15–39 years), carries the potential for morbidity and mortality.

Methods

Hybrid-capture-based comprehensive genomic profiling (CGP) was performed prospectively on 512 consecutively submitted thyroid carcinomas, including 58 from pediatric and AYA (PAYA) patients, to identify genomic alterations (GAs), including base substitutions, insertions/deletions, copy number alterations, and rearrangements. This PAYA data series includes 41 patients with papillary thyroid carcinoma (PTC), 3 with anaplastic thyroid carcinoma (ATC), and 14 with medullary thyroid carcinoma (MTC).

Results

GAs were detected in 93% (54/58) of PAYA cases, with a mean of 1.4 GAs per case. In addition to BRAF V600E mutations, detected in 46% (19/41) of PAYA PTC cases and in 1 of 3 AYA ATC cases, oncogenic fusions involving RET, NTRK1, NTRK3, and ALK were detected in 37% (15/41) of PAYA PTC and 33% (1/3) of AYA ATC cases. Ninety-three percent (13/14) of MTC patients harbored RET alterations, including 3 novel insertions/deletions in exons 6 and 11. Two of these MTC patients with novel alterations in RET experienced clinical benefit from vandetanib treatment.

Conclusion

CGP identified diverse clinically relevant GAs in PAYA patients with thyroid carcinoma, including 83% (34/41) of PTC cases harboring activating kinase mutations or activating kinase rearrangements. These genomic observations and index cases exhibiting clinical benefit from targeted therapy suggest that young patients with advanced thyroid carcinoma can benefit from CGP and rationally matched targeted therapy.
Effects of vertical loading on lateral screw pile performance
Authors: Al-Baghdadi Therar A. , Brown Michael J. , Knappett Jonathan A. , Al-Defae Asad H.
Published: February 2017

The offshore wind energy sector faces new challenges as it moves into deeper water deployment. To meet these challenges, new and efficient foundation solutions are required. One potential solution is to upscale onshore screw piles but they require verification of performance for new geometries and demanding loading regimes. This paper presents a three-dimensional finite-element analysis investigation of screw pile behaviour when subjected to combined vertical and lateral loading in sand. In the investigation, the screw pile length and helical plate diameter were varied on piles with a fixed core diameter while subjecting the piles to combined axial and lateral loading. The results were compared with results from straight shafted piles with the same core diameter. The results of the analysis revealed that vertical compression loads increased the lateral capacity of the screw piles whereas vertical uplift loads marginally reduced the lateral capacity. The downside of this enhanced lateral capacity is that the screw piles experience higher bending moments. This suggests that, when using screw piles for offshore foundation applications, structures should be designed to maintain axial compressive loads on the piles and induced bending moments need to be adequately assessed when deciding on appropriate structural sections.
Macrophage-to-Myofibroblast Transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury
Authors: Wang Ying-Ying , Jiang Hong , Pan Jun , Huang Xiao-Ru , Wang Yu-Cheng , Huang Hong-Feng , To Ka-Fai , Nikolic-Paterson David J. , Lan Hui-Yao , Chen Jiang-Hua
Published: February 2017

Interstitial fibrosis is an important contributor to graft loss in chronic renal allograft injury. Inflammatory macrophages are associated with fibrosis in renal allografts, but how these cells contribute to this damaging response is not clearly understood. Here, we investigated the role of macrophage-to-myofibroblast transition in interstitial fibrosis in human and experimental chronic renal allograft injury. In biopsy specimens from patients with active chronic allograft rejection, we identified cells undergoing macrophage-to-myofibroblast transition by the coexpression of macrophage (CD68) and myofibroblast (α–smooth muscle actin [α-SMA]) markers. CD68+/α-SMA+cells accounted for approximately 50% of the myofibroblast population, and the number of these cells correlated with allograft function and the severity of interstitial fibrosis. Similarly, in C57BL/6J mice with a BALB/c renal allograft, cells coexpressing macrophage markers (CD68 or F4/80) andα-SMA composed a significant population in the interstitium of allografts undergoing chronic rejection. Fate-mapping in Lyz2-Cre/Rosa26-Tomato mice showed that approximately half ofα-SMA+myofibroblasts in renal allografts originated from recipient bone marrow–derived macrophages. Knockout ofSmad3protected against interstitial fibrosis in renal allografts and substantially reduced the number of macrophage-to-myofibroblast transition cells. Furthermore, the majority of macrophage-to-myofibroblast transition cells in human and experimental renal allograft rejection coexpressed the M2-type macrophage marker CD206, and this expression was considerably reduced inSmad3-knockout recipients. In conclusion, our studies indicate that macrophage-to-myofibroblast transition contributes to interstitial fibrosis in chronic renal allograft injury. Moreover, the transition of bone marrow–derived M2-type macrophages to myofibroblasts in the renal allograft is regulatedviaa Smad3-dependent mechanism.
Galactosylation of IgA1 Is Associated with Common Variation in C1GALT1
Authors: Gale Daniel P. , Molyneux Karen , Wimbury David , Higgins Patricia , Levine Adam P. , Caplin Ben , Ferlin Anna , Yin Peiran , Nelson Christopher P. , Stanescu Horia , Samani Nilesh J. , Kleta Robert , Yu Xueqing , Barratt Jonathan
Published: February 2017

IgA nephropathy (IgAN), an important cause of kidney failure, is characterized by glomerular IgA deposition and is associated with changes in O-glycosylation of the IgA1 molecule. Here, we sought to identify genetic factors contributing to levels of galactose-deficient IgA1 (Gd-IgA1) in white and Chinese populations. Gd-IgA1 levels were elevated in IgAN patients compared with ethnically matched healthy subjects and correlated with evidence of disease progression. White patients with IgAN exhibited significantly higher Gd-IgA1 levels than did Chinese patients. Among individuals without IgAN, Gd-IgA1 levels did not correlate with kidney function. Gd-IgA1 level heritability (h2), estimated by comparing midparental and offspring Gd-IgA1 levels, was 0.39. Genome-wide association analysis by linear regression identified alleles at a single locus spanning the C1GALT1 gene that strongly associated with Gd-IgA1 level (β=0.26; P=2.35×10−9). This association was replicated in a genome-wide association study of separate cohorts comprising 308 patients with membranous GN from the UK (P<1.00×10−6) and 622 controls with normal kidney function from the UK (P<1.00×10−10), and in a candidate gene study of 704 Chinese patients with IgAN (P<1.00×10−5). The same extended haplotype associated with elevated Gd-IgA1 levels in all cohorts studied. C1GALT1 encodes a galactosyltransferase enzyme that is important in O-galactosylation of glycoproteins. These findings demonstrate that common variation at C1GALT1 influences Gd-IgA1 level in the population, which independently associates with risk of progressive IgAN, and that the pathogenic importance of changes in IgA1 O-glycosylation may vary between white and Chinese patients with IgAN.
Macroeconomic Forecasting in Times of Crises
Authors: Guerrón-Quintana Pablo , Zhong Molin
Published: February 2017

We propose a parsimonious semiparametric method for macroeconomic forecasting during episodes of sudden changes. Based on the notion of clustering and similarity, we partition the time series into blocks, search for the closest blocks to the most recent block of observations, and with the matched blocks we proceed to forecast. One possibility is to compare local means across blocks, which captures the idea of matching directional movements of a series. We show that our approach does particularly well during the Great Recession and for variables such as inflation, unemployment, and real personal income. When supplemented with information from housing prices, our method consistently outperforms parametric linear, nonlinear, univariate, and multivariate alternatives for the period 1990 - 2015.
An Intervention Study: Removing Supplemented Materials from Montessori Classrooms Associated with Better Child Outcomes
Authors: Lillard Angeline S , Heise Megan J
Published: February 2017

Montessori classrooms vary a good deal in implementation, and one way in which implementation differs is the provision of materials.  Specifically, some classrooms use only Montessori materials, whereas others supplement the Montessori materials with commercially available materials like puzzles and games.  A prior study suggested this might be a reason for observed differences across studies and classrooms (Author, 2012) but an intervention study is the best test.  The present study presents such an intervention with 52 children in 3 Montessori classrooms with Supplementary materials. All children were given 6 pretests, and non-Montessori materials were removed from 2 of the classrooms.  Four months later, children were retested to see how much they changed across that period.  Children in the classrooms from which the non-Montessori materials were removed advanced significantly more in early reading and executive function, and to some degree advanced more in early math.  There were no differences across the classroom types in amount of change on the tests of vocabulary, social knowledge, or social skills.
From the Editor
Authors: Murray, PhD Angela K.
Published: February 2017

Welcome to the second issue of the Journal of Montessori Research.
Racial and Economic Diversity in U.S. Public Montessori Schools
Authors: Debs Mira Catherine
Published: February 2017

As public Montessori schools rapidly expand through the United States, the question then arises: What population of students do the schools serve? This study presents a new empirical data set examining the racial and economic diversity of 300 whole-school, public Montessori programs open in 2012–2013, where the entire school uses the Montessori Method. While school-choice scholars are concerned that choice programs like Montessori lead to greater student segregation by race and social class, this study finds a variety of outcomes for public Montessori. Public Montessori as a sector has strengths in student racial and socioeconomic diversity, but it also has diversity challenges, particularly among Montessori charters. The study concludes with recommended strategies for public Montessori schools to enroll a racially and economically diverse student body.
MODEL PEMBELAJARAN PENDIDIKAN LINGKUNGAN HIDUP PADA PENDIDIKAN ANAK USIA DINI
Authors: Djoehaeni Heny
Published: February 2017

Abstract, Issues relating to the environment is a global issue that demands attention from various sectors including education . Sullivan in Bezzina (2006 ) states that the environmental crisis is a social issue and not a matter of merely natural . Environmental education has a very important role in addressing environmental problems that arise at this time . Although the policy published by the government of West Java, but at the level of implementation required a learning model which could be a reference to the teacher in implementing the learning of Environmental Education in Early Childhood Education. The method used in this study is Research and Development with the following phases: preliminary study include literature studies , field surveys and preparation of the initial product . The development phase includes limited testing and trials as well as broader validation phase . Result shows that Environmental Education in Early Childhood education is still not optimal . Learning model is developed with the model based on Contextual Inquiry process . Implementation of Contextual Inquiry-based learning model in the Learning Environment Education in Early Childhood Education can improve children's learning outcomes , especially in the sphere of competence of knowledge , attitudes and skills which refers to the Local Content Curriculum Environmental Education. .Keywords : Environmental Education, Early childhood Education, CurriculumAbstrak, masalah-masalah yang berhubungan dengan lingkungan merupakan isu global yang menuntut perhatian dari berbagai sektor termasuk pendidikan. Sullivan di Bezzina ( 2006) menyatakan bahwa krisis lingkungan merupakan masalah sosial dan bukan semata-mata sesuatu yang alami. Pendidikan Lingkungan Hidup memiliki peran yang sangat penting dalam menangani masalah lingkungan yang muncul saat ini. Meskipun kebijakan diterbitkan oleh pemerintah Jawa Barat, tetapi pada tingkat implementasi diperlukan model pembelajaran yang dapat menjadi acuan untuk guru dalam melaksanakan pembelajaran Pendidikan Lingkungan Hidup pada Pendidikan Anak Usia Dini. Metode yang digunakan dalam penelitian ini adalah Penelitian dan Pengembangan dengan tahap-tahap berikut: studi pendahuluan meliputi studi literatur, survei lapangan dan penyusunan produk awal. Tahap pengembangan termasuk pengujian terbatas dan uji coba serta tahap validasi yang lebih luas. Hasil menunjukkan bahwa Pendidikan Lingkungan Hidup pada Pendidikan Anak Usia Dini masih belum optimal. Sebuah model pembelajaran dikembangkan dengan model yang didasarkan pada proses inkuiri kontekstual. Penerapan model pembelajaran berbasis inkuiri kontekstual pada Pendidikan Lingkungan Hidup pada Pendidikan Anak Usia Dini dapat meningkatkan hasil belajar anak-anak, terutama pada ranah kompetensi pengetahuan, sikap dan keterampilan yang mengacu pada Kurikulum Muatan Lokal Pendidikan Lingkungan Hidup.Kata Kunci: Pendidikan Lingkungan Hidup, Pendidikan Anak Usia Dini, kurikulum
KOMUNIKASI KRISIS: ANALISIS UPAYA RESPON KRISIS TELUK MEKSIKO DARI PERSPEKTIF PUBLIC RELATIONS
Authors: Koswara Aang
Published: February 2017

Abstract, crisis communication is a situation that may cause effects on the company's sustainability business operations; the treatment at every stage of the crisis will minimize the negative public reaction against the company. This paper reviews the crisis of BP Oil Company that had a leak in the Gulf of Mexico that resulted in the spill along the coast a few U.S. states that threaten ecosystems and marine life, tourism businesses and the livelihoods of fishermen population around the spill from the perspective of public relations. Communication crisis began when BP made a number of controversial statements to the public through the mass media which resulted negatives responses from the Government of the United States, communities around the spill, a shareholder in the stock, and environmental activists. BP responsed this negative public reaction is generated through a crisis communication in the form of lobbying to the Government of the United States and key stakeholders as well as the handling of campaign messages through social media networking and mass media.Keywords: Communication Disaster, Public Relations, Communication CrisisAbstrak, krisis komunikasi merupakan sebuah situasi yang dapat menimbulkan efekberkelanjutan operasional bisnis perusahaan pada masa yang akan datang, perlakuan dalamtiap tahapan krisis akan membantu meminimalisir reaksi negatif publik terhadapperusahaan. Tulisan ini memaparkan tinjauan krisis dari perspektif public relations terhadapperusahaan minyak BP yang mengalami kebocoran di Teluk Meksiko yang mengakibatkantumpahan di sepanjang pesisir pantai beberapa negara bagian Amerika Serikat yangmengancam ekosistem dan biota laut, bisnis pariwisata, dan mata pencaharian nelayanpenduduk sekitar tumpahan. Krisis komunikasi BP dimulai ketika sejumlah pernyataankontroversial disampaikan kepada publik melalui sejumlah media massa yangmengakibatkan reaksi negatif dari Pemerintah Amerika Serikat, komunitas sekitartumpahan, pemegang saham di bursa, dan aktivis lingkungan. Respon BP terhadap reaksinegatif publik tersebut dimunculkan melalui komunikasi krisis dalam bentuk upaya lobikepada Pemerintah Amerika Serikat dan pemegang saham kunci serta kampanye pesanpenanganan melalui jejaring media sosial dan media massa.Kata Kunci : Bencana Komunikasi, Public Relations, Komunikasi Krisis
URGENSI PENJAMINAN MUTU SEKOLAH
Authors: Kurniawan Deni
Published: February 2017

Abstract, human resources have a central role in the development and advancementof an organization. Human recources development is closely related to educationalinstitutions, one of which is school. In order to optimize the process education in schools, itis important to ensure school quality assurance system. The goal of this system is to fulfillthe satisfaction of education stakeholders. To find out the expectations and satisfaction ofthe stakeholders, a school can obtain information by using various alternative ways deemedsuitable with the kind of information expected and the resources owned by the school.Keywords: quality assurance, satisfaction, stakeholdersAbstrak, sumber daya manusia memiliki peranan sentral bagi pengembangan dankemajuan organisasi. Pengembangan SDM terkait erat dengan lembaga pendidikan, salahsatunya adalah sekolah. Agar proses penyelenggaraan pendidikan di sekolah bisa optimalmaka penting adanya sistem jaminan kualitas sekolah. Tujuan utama dari sistem jaminankualitas sekolah adalah agar terpenuhinya kepuasan stakeholders pendidikan. Untukmengungkap harapan dan kepuasan stakeholders sekolah bisa dilakukan melalui penggalianinformasi dengan menggunakan beragam alternatif cara yang dipandang sesuai denganjenis informasi yang diharapkan dan keberadaan sumber daya yang dimiliki sekolah.Kata Kunci: jaminan kualitas, kepuasan, stakeholders,informasi
MEMBANGUN KARAKTER MAHASISWA BERBASIS NILAI-NILAI PANCASILA SEBAGAI RESOLUSI KONFLIK
Authors: - Supriyono
Published: February 2017

Abstract, Condition of Indonesia is now being hit by a climate of character which does not support the output of Pancasila culture . The waning of characters can be seen from the number of people taking drugs, fighting between the village and the school , consumerist lifestyle , which is concerned with the practice of religious life and the juridical formalism symbols that make it easy to competed. The crisis of character now has spread on campus so easily found student attitudes and behaviors that conflict with moral values .As a man who respects the harmony and compatibility of national identity as it is appropriate if the values of Pancasila moral values to serve as a foundation to live a life of society , nation and state . Ethical principles of Pancasila intrinsically humanistic , meaning that the values of Pancasila based on values rooted in the dignity of man as a being cultured . Pancasila as the state ideology of the nation and contain values of divinity , human values, the value of unity , democratic values and the values of justice . If people are able to realize and really be able to run five moral rules or values contained in the fifth Pancasila , then humans can save the nation from various conflicts . Building character through the values of Pancasila can unite the entire diversity of Indonesia .Keywords : Character , values of Pancasila , and Conflict ResolutionAbstrak, Kondisi bangsa Indonesia sekarang sedang dilanda oleh sebuah iklim karakter kehidupan yang tidak mendukung tumbunya budaya Pancasila. Memudarnya karakter dapat dilihat dari banyaknya orang mengkonsumsi narkoba, tawuran antar kampung dan sekolah, pola hidup konsumeris, praktik hidup keagamaan yang mementingkan formalisme yuridis dan simbol-simbol yang memudahkan untuk diadu domba. Krisis karakter sekarang ini sudah menjalar pada lingkungan kampus sehingga mudah ditemui sikap dan perilaku mahasiswa yang bertentangan dengan nilai moral.Sebagai manusia yang menjunjung keharmonisan dan keserasian sebagai jati diri bangsa maka sangatlah tepat jika nilai-nilai Pancasila dijadikan sebagai nilai moral untuk landasan dalam menjalani kehidupan bermasyarakat, berbangsa dan bernegara. Prinsip etika Pancasila pada hakikatnya bersifat humanistik, artinya nilai-nilai Pancasila mendasarkan pada nilai yang bersumber pada harkat dan martabat manusia sebagai makhluk yang berbudaya. Pancasila sebagai dasar negara dan ideologi bangsa mengandung nilai ketuhanan, nilai kemanusiaan, nilai persatuan, nilai kerakyatan dan nilai keadilan. Apabila manusia mampu menyadari dan benar-benar bisa menjalankan kelima aturan moral atau kelima nilai yang terkandung dalam Pancasila, maka manusia dapat menyelamatkan bangsa dari berbagai konflik. Membangun karakter melalui nilai-nilai Pancasila dapat mempersatukan seluruh kebhinekaan bangsa Indonesia.Kata Kunci: Karakter, Nilai-nilai Pancasila, dan Resolusi Konflik
MENGEMBANGKAN KETERAMPILAN BERPIKIR TINGKAT TINGGI MAHASISWA MELALUI MEDIA SOSIAL
Authors: Hanoum R Nadia
Published: February 2017

Abstract. Social media allow their users to share, collaborate, and making network more flexibly without having to be in the same place and time. The use of social media in learning gives students more opportunities to interact and exchange information with each other through various activities like discussion, peer correction, and peer evaluation. Viewing from social learning and social constructivism theories, using social media in learning will affect students’ behavior and learning outcomes. The learning outcomes explored in this paper is the cognitive domain of analyze, evaluate, and create aspects. These three aspects are considered as higher order thinking skills which should be mastered by college students as it is at university level that quality human resources are expected to be generated.Keywords: higher order thinking skills, social media, social learning theoryAbstrak. Media sosial memungkinkan para penggunanya untuk berbagi, berkolaborasi, dan berjejaring secara lebih fleksibel tanpa harus berada pada tempat dan waktu yang sama. Penggunaan media sosial dalam pembelajaran memberikan kesempatan yang lebih banyak kepada peserta didik untuk berinteraksi dan bertukar informasi dengan peserta didik lainnya melalui berbagai kegiatan seperti diskusi, mengoreksi informasi yang diberikan oleh teman atau kelompok lain atau memberikan penilaian terhadap kinerja atau penampilan teman sekelas. Jika dilihat dari teori belajar sosial dan teori konstruktivisme sosial, maka penggunaan media sosial dalam pembelajaran akan berdampak pada perilaku dan hasil belajar peserta didik. Hasil belajar yang dieksplor dalam artikel ini adalah domain kognitif aspek menganalisis, mengevaluasi, dan menciptakan. Ketiga aspek ini merupakan keterampilan berpikir tingkat tinggi yang harus dapat dikuasai oleh mahasiswa mengingat pada level pendidikan tinggi lah diharapkan akan dihasilkan SDM yang berkualitas.Kata Kunci: keterampilan berpikir tingkat tinggi, media sosial, teori belajar sosial
THE PUBLIC SPHERE AS THE EDUCATION OF MULTICULTURALISM AWARENESS
Authors: - Yusar
Published: February 2017

Abstract. This article was endeavor to describe the  awareness multicultural education in the Chinese Lampion Festival in Kota Bandung since 2011 to 2013. The research was held with the longitudinal, qualitative, and adopt to the action research methods. The evidence was describe that the public sphere was success to build the communicative action between the native ethnics and the Chinese. By the public sphere, each ethnics perceived their cultural differences and appreciate as an equality.  By this public sphere, the multiculturalism awareness was formed succesfully and reduce the ethnical stereotype between the native ethnics and the Chinese.  This article conclude that the awareness multicultural education may be doing by creating the public spheres. Keywords:   public sphere, education, multiculturalism Abstrak. Artikel ini menggambarkan pendidikan kesadaran multikulturalisme  melalui perayaan Cap Go Meh.  Etnis-etnis tempatan yang mengklaim sebagai pribumi memiliki stereotipe etnis yang kuat terhadap etnis Tionghoa. Penelitian telah dilakukan dengan paradigma kualitatif yang bersifat longitudinal mengadopsi pada metode action research. Hasil penelitian menunjukkan bahwa ruang publik yang dibangun antara etnis tempatan dengan etnis Tionghoa memunculkan tindakan komunikatif antar etnis.  Melalui penciptaan ruang publik tersebut, kesadaran akan keberagaman muncul dari masing-masing etnis dan memadang bahwa budaya masing-masing berdiri setara dan muncul penghargaan atas masing-masing kebudayaan. Pemahaman multikulturalisme terbangun karena ruang publik yang diciptakan. Bagian penutup dijelaskan bahwa pendidikan kesadaran multikultur dapat ditempuh melalui penciptaan ruang-ruang publik. Kata kunci:  ruang  publik, pendidikan, multikulturalisme
THE APPLICATION OF TSTS MODEL IN CIVIC EDUCATION LESSON IN IMPROVING STUDENTS’ LEARNING ABILITY
Authors: Herfina Hanna
Published: February 2017

Abstract, The background of this research is the need of various learning method to improve student’s learning ability. One of them is TSTS (two stay to stray). The purpose of this research is to examine TSTS learning method effectiveness in improving student’s learning ability and how much improvement made in implementing TSTS learning method. This research uses cooperative learning with two stay to stray (TSTS) model and action research method trial on learning process of PKn subject at Elementary School. The result of the research indicates improvement on students’ ability on PKn subject by using TSTS learning method, and the effectiveness of this model is proven with the increase of average score of 83.41%. TSTS model in First and Second cycle has proven, exponentially, contributes to the increase of students’ learning results.  Keyword:  effectiveness, learning method, TSTS model, Elementary School students.  Abstrak, Penelitian ini dilatarbelakangi dengan adanya kebutuhan mengenai metode pembelajaran yang bervariasi untuk meningkatkan kemampuan belajar siswa, salah satunya dengan penerapan model pembelajaran TSTS. Adapun tujuan penelitian ini adalah untuk mengetahui efektivitas model pembelajaran TSTS dalam meningkatkan kemampuan belajar Siswa dan seberapa besar peningkatan kemampuan siswa dalam menerapkan model pembelajaran TSTS.          Penelitian ini menggunakan konsep cooperative learning dengan model two stay to stray(TSTS), serta metode action research yang diujikan dalam proses belajar mengajar siswa Sekolah Dasar pada materi PKn. Sedangkan untuk hasil yang diperoleh adalah terdapat peningkatan kemampuanSiswa dalam pembelajaran PKn dengan model pembelajaran TSTS dan keefektifan melalui pemanfaatan model pembelajaran TSTS terbukti dengan meningkatnya nilai rata-rata sebesar83,41. Hal itu sudah menandakan bahwa penggunaan model TSTS di dalam siklus I dan II memberikan kontribusi yang sangat besar bagi peningkatan hasil belajar siswa.Kata kunci: efektivitas,metode pembelajaran, model TSTS, siswa SD.
THE PUBLIC RELATION LITIGATION STRATEGIES OF PT POS INDONESIA COMMUNICATION DIVISION IN DEALING WITH THE PROCUREMENT OF PERSONAL DATA TERMINAL
Authors: Widhiarti, dkk Chandra Kesuma
Published: February 2017

Abstract, Strategic Public Relations is the way that has been planned to obtain a certain result. The result can be the purpose or goal of the objectives to be achieved by the company. Likewise with PT Pos Indonesia (Persero) which is handling the crisis through Litigation Public Relations. Crisis management must be done quickly and accurately so it requires careful planning. The purpose of this descriptive study was to determine strategies Public Relations Corporate Communications team, especially when the crisis is still being processed in court. Public Relations strategy is tailored to the stage of settling disputes in court. Keyword: Crisis, Litigation PR, Public Relations Public Relations Strategy Abstrak, Strategi Public Relations merupakan cara yang telah direncanakan untuk mendapatkan hasil tertentu. Hasil tersebut dapat berupa tujuan ataupun sasaran dari tujuan yang ingin dicapai oleh perusahaan. Demikian halnya dengan PT Pos Indonesia (Persero) yang tengah menangani krisis melalui Litigasi Public Relations. Penanganan krisis harus dilakukan dengan cepat dan tepat sehingga diperlukan perencanaan yang matang. Tujuan dari penelitian deskriptif ini adalah untuk mengetahui strategi Public Relations Tim Komunikasi Korporat khususnya ketika krisis masih diproses di Pengadilan. Strategi Public Relations tersebut disesuaikan dengan tahap penyelesaian perkara yang ada di Pengadilan.Kata Kunci: Strategi Public Relations, Litigasi PR, Krisis, Public Relations
COMPARISON USING MEDIA CARD IMAGES AND ANIMATION IN IMPROVING THE KNOWLEDGE METAMORPHOSIS OF ANIMALS IN DEAF CHILDREN
Authors: Sutisna Nia
Published: February 2017

Abstrack, The study, entitled "comparison using the media card images and animations to improve the knowledge of animal metamorphosis in deaf children", aims to determine the differences in media use picture cards and animations based on the results of the test after the treated media. Methods This study uses a quantitative approach to experiment with the design of Counter Balance, is the rotation design allows two classes of media research to get the same treatment, as for data analysis using the Wilcoxon test. This research was conducted in class IV and V SLB Gandasari Indramayu with a total sample of eight people and made two groups according to the class. The results of the test scores after tested with Wilcoxon test calculations in may conclude that researchers propose hypotheses accepted, that there are differences in the use of media cards and animated images in increasing knowledge of animal metamorphosis in deaf children. This study is expected to be a reference to the suggestion that more and more schools are given attention on the use of the media, especially the animation of deaf children to help improve knowledge in the subject matter.Keywords: Animal Metamorphosis Knowledge, Media Card Image, Animation.Abstrak, penelitian yang berjudul “perbandingan menggunakan media kartu gambar dan animasi dalam meningkatkan pengetahuan metamorfosis hewan pada anak tunarungu”, bertujuan untuk mengetahui perbedaan penggunaan media kartu gambar dan animasi berdasarkan hasil tes setelah diberi perlakuan media tersebut. Metode penelitian ini menggunakan pendekatan kuantitatif eksperimen dengan desain Counter Balance, yaitu desain rotasi yang memungkin dua kelas penelitian mendapatkan perlakuan media yang sama, adapun analisis datanya menggunakan uji Wilcoxon. Penelitian ini dilakukan di kelas IV dan V SLB Gandasari Indramayu dengan jumlah sampel sebanyak delapan orang dan dijadikan dua kelompok sesuai kelas. Hasil skor tes setelah diuji dengan perhitungan Uji Wilcoxon didapat kesimpulan hipotesis yang peneliti ajukan diterima, yaitu terdapat perbedaan penggunaan media kartu gambar dan animasi dalam meningkatkan pengetahuan metamorfosis hewan pada anak tunarungu. Penelitian ini diharapkan dapat menjadi acuan saran bagi sekolah agar semakin lebih diberi perhatian tentang penggunaan media khususnya animasi bagi anak tunarungu untuk membantu meningkatkan pengetahuan dalam hal materi pelajaran.Kata kunci: Pengetahuan Metamorfosis Hewan, Media Kartu Gambar, Animasi.
Renal safety profile of di-peptidyl-peptidase inhibitors: a review of available literature
Authors: Dey Arindam , A.G. Unnikrishanan , Saxena Gaurav , Jain Rishi
Published: February 2017

Diabetic Nephropathy has become the single most import cause of End Stage Renal Disease (ESRD). Various strategies to limit or slow the progress the Diabetic nephropathy are suggested by the guidelines and evidences. By maintaining strict glycemic control the progression of diabetic nephropathy can be altered. Glycemic control in diabetic patients with nephropathy is complex as falling eGFR renders many ant diabetic medications contraindicated while others are needed to be done in low dose. The intent of this review article is to collate the available evidences for renal safety with one such anti diabetic class of medication, dipeptidyl peptidase 4 inhibitor and evaluate the guideline based antidiabetic treatment in Type 2 Diabetes Mellitus patients with renal insufficiency.
KARAKTERISTIK PROGRAM PEMBERDAYAAN MUSTAHIK OLEH LEMBAGA AMIL ZAKAT NASIONAL DI INDONESIA
Authors: Ernawati Ernawati
Published: February 2017

This study aims to investigate the characteristics of empowerment mustahik by Lembaga Amil Zakat Nasional (LAZNAS). The sample consisted of 13 LAZNAS. Data obtained through the publication of directories on line LAZNAS. Characteristics of the empowerment program assessed in six dimensions: type of aid, the target group, target area, target age, gender and agriculture-based . The data were analyzed descriptively with tabulation, percentages and charts. The results showed that the type of the empowerment program conducted by LAZNAS in Indonesia consists of: financial aid, assistance tools, training and mentoring, as well as other type such as reinforcement, the legality of operations and strengthening the network of business. However, not all LAZNAS adopt this type of aid. The whole LAZNAS have targeted both mustahik empowering individuals and groups. LAZNAS also generally have a Village Project. On the other hand, LAZNAS in general has given space to the development of community enterprises in the agricultural sector. But lack of attention at a young age and female mustahik. Only three LAZNAS that provides direct attention to the younger group; and one for woman empowerment.
PREFERENSI MASYARAKAT TERHADAP LEMBAGA ZAKAT DAN BENTUK-BENTUK PEMBERDAYAAN DANA ZAKAT
Authors: Muthohar Ahmad Mifdlol
Published: February 2017

This study aims to find out the attitude of muzaki in handing over the zakat fund and their perspective of the zakat institution. This study used a qualitative approach, located in 13 cities. The research findings showed that according to muzaki, paying zakat to zakat institution is more ideal, however, they prefer to pay it with two different ways; first is to zakat institution and second is directly given to those who deserve to receive it. Muzaki prefer to pay their zakat to private zakat institutions rather than to those belong to government. Then Zakat funds should be managed by the institution of zakat. If the government manages the zakat, it should be fair and believable. Furthermore, muzaki are more satisfied when zakat institutions distribute the zakat to people around muzaki. It is for the Benefit of the most desired purpose that is educational, social, religious, economic empowerment and health.
Perceived Attributes of innovation: Perceived security as an additional attribute to Roger’s Diffusion of Innovation Theory
Authors: Tanye Hannah Ayaba
Published: February 2017

The study attempts to contribute to the recent call on security issues in eLearning.  Security issues in eLearning have been advanced at organizational level.  These concerns had not been put in the light of effects on the diffusion of eLearning practice.  eLearning involves the use of the web, digital media to deliver knowledge and skills.  There is lack of the perspective of security issues at the individual level as a facilitator to the diffusion of innovations.  This study proposes perceived security and how it affects the diffusion of eLearning practices in HEI as an additional perceived eLearning (innovation) attribute.  The study seeks to find out the extent to which perceived security affect eLearning diffusion in the Universities.                    The research adopts a quantitative approach by the use of surveys.  A survey has the capability of getting a wider and global perspective.  Thus, these generalized views facilitate inform decision making in Universities’ eLearning practice.  The dependent variable for the quantitative approach is the diffusion of eLearning practice in the Universities. The independent variables are the perceived characteristics of eLearning system by students and the factors that characterize students’ adoption of eLearning systems in Universities.                    The study found out that perceived security had the highest effect on eLearning diffusion among the students in the three Universities.
ENERGY SECURITY: TODAY AND TOMORROW
Authors: Srivastava Dr. Babita
Published: February 2017

Purpose:To emphasize the importance of renewable and alternative energy, as nations become increasingly reliant on increasingly less available conventional energy sources. Simultaneously, the long-term and detrimental effects of such reliance is explored and quanitified so as to better justify investments into renewable, widely available, and less polluting energy sources.Design/Metholody/Approach:Data is collected from a variety of publicly available sources and their relevance is explored through contrast and comparison. The graphs and data used primarily focus on energy and energy consumption such as fuel pricing and exporting as well as the rate of fuel exporting by various nations.Findings:Based on the data analyzed, through the continuous use of fossil fuels, a country faces multiple challenges: depletion of fossil fuel reserves, global warming, environmental concerns, geopolitical and military conflicts and, of late, a continued and significant fuel price rise. The authors conclude these problems create an unsustainable situation and that without converting their energy sector to at least be in part less reliant on hydrocarbons and similar fuels and more reliant on more widely available and less polluting energy sources such as sunlight or geothermal energy a nation will inevitably face a catastrophic collapse of their energy sector.Research Limitations/Implications:Without cooperation of the governments of leading energy consuming nations in redeveloping their energy sector based on this or similar research, little of what has been explored can be widely applied. Consequently, the conclusions of this paper represent a single step in the process of redefining worldwide energy consumption rather than giving an explicit answer. Further research will be needed in order to most fully present an effective argument to the public sector, the private sector, and the common citizen that energy habits must be changed.Originality/value:The conclusions reached are an essential part to understanding the wide reaching effects of the world’s current energy habits. With the ever increasing threat of global warming, emptying fuel reserves, and unnecessary polluting and waste habits of most nation’s energy sectors, this research, along with the cited data, can aid in the redirection of such energy habits before a point of no return.
INEQUALITY OF GENDER RATIO AMONG RELIGIOUS AND SOCIAL GROUPS IN INDIA
Authors: Gavhale Sandipan R.
Published: February 2017

India was a mother-dominant country. But today, the atrocities event ratio and the gender gap in India have increased, which is serious and considerable matter. The male-female ratio in society is an indicator of the socio-economic progress of the country, considering this point, the social condition of India, is not improved by satisfactory.There are many social groups and various distinct cultures their effects become on unequal sex ratio this inequality exists into the upper caste. So this article focuses on class wise gender ratio in India as comparative gender ratio of SC, ST to another social group like upper caste. So this matter should be examined in thought level. Consequently, the social problems are increasing day after day, which should be studied by the thinkers to be improved from this problematic situation.
ORGANIZATIONAL LEARNING MECHANISMS IN SOHAR UNIVERSITY
Authors: Jahwari Noura Al , Khan M. Firdouse Rahman
Published: February 2017

PurposeThe objective of the study is to critically examine the mechanisms of organizational learning in Sohar University and to identify the relationship between stages of organizational learning and mechanisms of organizational learning and to examine the effectiveness and the nurturance of the pedagogical practices.Design/methodology/approachThe study was conducted with 76 employees from all the departments of Sohar University, who were selected on a simple random sampling basis and were contacted through a well-defined questionnaire. FindingsThe study reveals that the employees of Sohar University are encouraged to attend external programs and seminars on new developments have been organized and the university prepares detailed plans reflecting contingency approaches. The study also confirmed that there is no relationship between demographic factors (Gender, age, qualification and teaching experience) and the Organizational learning. The study also reveals that there is an association between the Innovations, Implementation and Organization learning.Practical ImplicationsThe study has thrown light on the organizational learning process, which is the key driver in innovating, implementing and stabilizing.Research limitationsThe study was restricted to the academic staff from all the faculties of Sohar University. Many of them did not understand the concept. So the researcher has to explain them in detail before furnishing the detailed questionnaire.Social ImplicationsThe study can be extended to other colleges and universities in Oman so that the accuracy of the tools and techniques of organizational learning can be ascertained. This will induce high transmission goals to equip and uplift the participants in a positive and creative contribution.Originality/valueOnly a very few have examined the impact of Organization Learning in the Universities of Oman, and it is a first-hand study of its kind.
ENVIRONMENTAL IMPACT OF NUCLEAR POWER: LAW AND POLICY MEASURES IN INDIA
Authors: Singh Ajay Kumar , Singha Nalnish Chandr
Published: February 2017

Healthy and clean environment is a fundamental right in India, simultaneously in modern time energy requirements are increasing. It is required that dependency on traditional source of energy should be decreased because of environmental and other reasons. Nuclear energy undoubtedly a present day hope for the energy requirement due to rich and eco-friendly source of energy. But this source also contains some danger for human health and wellbeing.It is a basic question before every nation that what safety and regulatory measures should be adopted to secure the safe use of nuclear energy. This article is an attempt to analyse the impact radiations caused by nuclear accidents on human health and environment. It also analyse the international regulatory measures and national legal and policy measures, adopted to combat the nuclear disaster. The article enumerates the liability issue arise due to the enactment of new law in 2010, it analyse the controversy and provide concluding remarks on the issue.
Effect of Thyroxine on Development, Growth and Survival of Giant Gouramy (Osphronemus gouramy) Larvae
Authors: Mulyati S. , Junior M. Zairin , Raswin M. M.
Published: February 2017

ABSTRACT

This experiment was carried out in order to study the effect of thyroxine hormone addition at different stages of giant gouramy larvae on their development, growth, and survival rate.  Treatments were conducted by dipping giant gouramy larvae at different stages (1, 5, and 1 0 days after hatching) in 0. 1 ppm thyroxine hormone solution for 24 hours.  The result of this experiment showed that dipping of giant gouramy larvae at different stages in thyroxine hormone solution did not affect their development, growth, and survival rate.

Key words :  Giant gouramy larvae, thyroxine, development, growth, survival rate

 

ABSTRAK

Percobaan ini dilakukan untuk mengetahui pengaruh perbedaan umur larva ikan gurami yang direndam dalam hormon tiroksin terhadap perkembangan, pertumbuhan, dan kelangsungan hidup.  Larva ikan gurami yang digunakan diperoleh dari hasil penetasan dan kemudian dipelihara sebagai stok.  Periakuan dilakukan melalui perendaman larva ikan gurami pada umur yang berbeda (1, 5, dan 10 hari setelah menetas) dalam larutan tiroksin 0,1 ppm selama 24 jam.  Hasil percobaan menujukkan bahwa setelah 56 hari pemeliharaan, pemberian tiroksin yang dilakukan tidak berpengaruh nyata terhadap perkembangan, pertumbuhan, dan kelangsungan hidup ikan gurami.

Kata kunci :  Larva ikan gurami, tiroksin, perkembangan, pertumbuhan, kelangsungan hidup
Blood Glukose Response of Giant Gouramy (Osphronemus gaouramy, Lac.) to the Stress of Environmental Temperature Changes
Authors: Hastuti S. , Supriyono Eddy , Mokoginta Ing , Subandiyono .
Published: February 2017

This experiment was conducted to investigate blood glucose performance of giant gouramy (Osphronemus gouramy, Lac.) to environmental changes. Fish with body weight of about 52,15 g was used in the experiment. A hundred and twenty fish were subjected to stress by moving them to another aquarium containing cooler water for 5 minute before put them back to the origin aquarium. The stress treatments were Δ 0°C (A), Δ-3°C (B), Δ-6°C(C), and Δ-9°C(D). Blood glucose was measured at 0, 1, 2, 3, 4 and 5 hours post stress, each for 5 fish. During stress treatment, the survival offish were recorded. To study the role of insulin activation on reducing the stress effects, thirty fish were injected with insulin 2 IU/100 g body weight before subjected them to stressar. Blood glucose level of fish subjected to temperature stress of Δ-9°C was the greatest. The blood glucose response to temperature changes was linear, Y = 4,4543 X + 35,553 with R2 = 0,09976. The survival rate of fish was 100% for all treatments. Injected of insulin 2 IU/100 g body weight was able to reduce hyperglycemia that caused by stress.

Key words: Blood glucose, giant gouramy, Osphronemus gouramy, stress

 

ABSTRAK

Penelitian ini dilakukan dengan tujuan untuk mengetahui performa glukosa darah ikan gurami (Osphronemus gouramy, Lac.) dalam merespon perubahan suhu lingkungan. Ikan berbobot rata-rata 52,15 g sebanyak 120 ekor diberi stres dengan cara diangkat dan dipindahkan ke suatu wadah yang bersuhu lebih dingin selama 5 menit dan dikembalikan lagi ke wadah mula-mula. Perlakuan stres perubahan suhu dingin tersebut adalah A (Δ 0°C), B (Δ- 3°C), C (Δ-6°C) dan D (Δ-9°C). Glukosa darah diukur dari 5 ekor ikan pada jam ke 0, 1, 2, 3, 4 dan 5 jam pascastres. Kelangsungan hidup dihitung pada saat perlakuan stres. Untuk melihat peran aktivasi insulin dalam menekan efek stres, ikan sebanyak 30 ekor diinjeksi insulin 2 iu/100 g bobot badan sebelum diberi stres. Kadar glukosa darah ikan gurame yang diberi stres perubahan suhu dingin sebesar Δ-9°C mengalami peningkatan paling besar. Respon glukosa darah terhadap stres perubahan suhu tersebut berpola linier Y= 4,4543 X + 35,553, dengan R2 = 0,9976. Perlakuan tersebut menghasilkan kelangsungan hidup yang sama yaitu 100%. Injeksi insulin 2 IU/100 g bobot badan mampu menekan hiperglisemia akibat stres.
 Kata kunci: Glukosa darah, ikan gurami, Osphronemus gouramy, stres