bluuebunny/crossref_metadata_2025 huggingface dataset:
A novel silver complex with 4-hydroxycoumarin derivative: Synthesis, structure, and biological activity
Authors:   Pavol Jozef Šafárik University in Košice, Faculty of Science, Institute of Chemistry, Slovakia, Kurjan Jakub , Jendželovský Rastislav ,   Pavol Jozef Šafárik University in Košice, Faculty of Science, Department of Molecular Biology, Slovakia, Jendželovská Zuzana ,   Pavol Jozef Šafárik University in Košice, Faculty of Science, Department of Molecular Biology, Slovakia, Buľková Viktória ,   Pavol Jozef Šafárik University in Košice, Faculty of Science, Department of Molecular Biology, Slovakia, Vilková Mária ,   Pavol Jozef Šafárik University in Košice, Faculty of Science, NMR Laboratory, Slovakia, Litecká Miroslava ,   Institute of Inorganic Chemistry of the CAS, Department of Materials Chemistry,  Czech Republic;, Potočňák Ivan ,   Pavol Jozef Šafárik University in Košice, Faculty of Science, Institute of Chemistry, Slovakia
Published: October 2023

In this contribution, a novel coumarin-derivative ligand, and its silver(I) complex are reported. Ligand 3-(1-(2-pyridylamino)ethylidene)-2H-chromene-2,4-dione (HL) was prepared by reaction of 3-acetyl-4-hydroxycoumarin with 2-picolyl amine. Further, complex [Ag(HL)2]NO3 was prepared and both compounds were characterized by physico-chemical methods such as IR and NMR spectroscopy, elemental analysis, and structure of the ligand and the complex was confirmed by X-ray analysis. The stability of both compounds was measured by NMR spectroscopy. MTT assay and cell proliferation assay on human lung adenocarcinoma cell line A549 and human colorectal adenocarcinoma cell line HT-29 showed that complex was more active than free HL ligand.
Anticancer gallium(III) complexes with halogen- and nitroderivatives of 8- hydroxyquinoline
Authors:   Pavol Jozef Šafárik University in Košice, Faculty of Science, Institute of Chemistry, Slovakia, Potočňák Ivan , Litecká Miroslava ,   Institute of Inorganic Chemistry of the CAS, Department of Materials Chemistry,  Czech Republic;, Prachařová Jitka ,   Institute of Inorganic Chemistry of the CAS, Department of Materials Chemistry, Czech Republic, Hreusová Monika ,   Palacký University in Olomouc, Faculty of Science, Department of Biophysics, Czech Republic, Kašpárková Jana ,   Palacký University in Olomouc, Faculty of Science, Department of Biophysics, Czech Republic
Published: October 2023

Six gallium(III) complexes with halogen- or nitroderivatives of 8-hydroxyquinoline, [Ga(ClQ)3] (1), [Ga(BrQ)3] (2), [Ga(dIQ)3] (3), [Ga(CQ)3] (4), [Ga(NQ)3] (5) and [Ga(ClNQ)3]·MeOH were prepared as possible anticancer drugs (HClQ = 5-chloro-8-hydroxyquinoline, HBrQ = 7-bromo-8-roxyquinoline, HdIQ = 5,7-diiodo-8-hydroxyquinoline, HCQ = 5-chloro-7-iodo-8-ydroxyquinoline, HNQ = 5-nitro-8-hydroxyquinoline and HClNQ = 5-chloro-7-nitro-8-hydroxyquinoline). X-ray single crystal structure analysis of [Ga(ClQ)3]·MeOH (1 – MeOH) and 5 showed that both complexes are molecular complexes with Ga(III) coordinated in mer-fashion by N- and O-donor atoms of three ClQ and NQ ligands, respectively. The in vitro antiproliferative activity of 1 and 5 was evaluated against the human ovarian carcinoma cisplatin-sensitive A2780, breast carcinoma MDA-MB-231, and human colorectal carcinoma HCT-116 cell lines and their selectivity was verified on MRC5 pd30 cells from normal lung tissue. Complexes 1 and 5 display higher antiproliferative activity (IC50 values in the range 2.1–7 μM) compared to the respective ligands, used Ga(III) salts, cisplatin and oxaliplatin, and a significant selective antiproliferative potency (IC50 = 149 and 32 μM, respectively for MRC5pd30 cell line).
In silico Drug-Likeness, Pharmacokinetic and other ADME properties of 2- (aminomethyl)cyclopropane-1,1-dicarboxylic acid
Authors:   University of Kragujevac, Institute for Information Technologies, Serbia, Kostić Marina D. , Marjanović Jovana S. ,   University of Kragujevac, Faculty of Science, Serbia, Mangelinckx Sven ,   Ghent University, Faculty of Bioscience Engineering, Department of Green Chemistry and Technology, Divac Vera M. ,   University of Kragujevac, Faculty of Science, Serbia
Published: October 2023

Herein we present the results of in silico determination of Drug-Likeness, Pharmacokinetic and other ADME properties of 2-(aminomethyl)cyclopropane-1,1-dicarboxylic acid as an example constrained γ-amino dicarboxylic acid. The results of in silico screening of drug-likeness, pharmacokinetic and other ADME (absorption, distribution, metabolism and elimination) properties of 2-(aminomethyl)cyclopropane-1,1-dicarboxylic acid have revealed that this compound is not able to cross the blood-brain barrier, but it shows good solubility and gastrointestinal absorption. The possible target screening has indicated the family C G protein-coupled receptors as the most probable physiological targets. More specifically, the 2-(aminomethyl)cyclopropane-1,1-dicarboxylic acid has the highest structural similarity with the known compounds that act on metabotropic glutamate receptor, excitatory amino acid transporter and betaine transporter. Taking all the above into consideration, it can be concluded that our investigated compound could be considered as a candidate molecule for further structural transformations that could enable better pharmacological performance and physiochemical properties.
Investigation of binding mode of novel 2,4-diketo esters to BSA
Authors:   University of Kragujevac, Institute for Information Technologies, Serbia, Milović Emilija , Mihajlović Kristina ,   University of Kragujevac, Faculty of Science, Serbia, Joksimović Nenad ,   University of Kragujevac, Faculty of Science, Serbia, Petronijević Jelena ,   University of Kragujevac, Faculty of Science, Serbia, Janković Nenad ,   University of Kragujevac, Institute for Information Technologies, Serbia
Published: October 2023

2,4-Diketo esters are well-known for their wide pharmacological activities as well as their usage in a lot of synthetic transformations. The specific structure of 2,4-diketo esters with many carbonyl groups and the presence of keto-enol tautomerism give suitable chemical properties for many applications. Therefore, an affinity for one of the binding sites of bovine serum albumin (BSA) of 2,4-diketo esters possessing good antimicrobial activity, was examined. Binding modes of compounds A and B were determined using fluorescence spectroscopy. Eosin Y was used as a marker for Sudlow’s Site I (subdomain IIA), while ibuprofen was used as a marker for Sudlow’s Site II (subdomain IIIA). Obtained values of Ka suggested that both compounds reversibly bind to BSA. Due to the values of Ka in the presence of site markers, the site II is more likely to be occupied by compound A, and compound B uses other binding modes. The presented results will help to improve the research of the mechanism of the interaction between transport proteins and similar compounds.
Compliance In Medical Waste Management During The Covid-19 Pandemic at Private Dental Clinic, Jakarta
Authors: Kristianto Jusuf , Rachmat Nur
Published: October 2023

Waste management is part of environmental health activities that aim to protect the community from the dangers of environmental pollution sourced from health waste. To avoid these risks, waste management in health service facilities is needed. Purpose: To get an overview of dental assistant compliance in medical waste management during the COVID-19 pandemic at private dental clinics in South Jakarta in 2022. Method: This research is a descriptive study. with a sample of 30 private dental clinics in South Jakarta. The sample determination technique used in this study is a random sampling technique. Results: The results of the study show that private dental clinics in the South Jakarta area that have SOPs but are not perfect are 24 clinics (80.0%), which have SOP's there were 6 clinics (20.0%) and 16 respondents were compliant (53.3%) in medical waste management, and 14 respondents were non- compliant (46.7%) in medical waste management. Conclusion: Most private dental clinics in South Jakarta have SOP's, but they are not perfect. However, most dental assistants are obedient in the management of medical waste.
Manajemen Krisis SMA YPHB dalam Menangani Berita Negatif Terkait Kenakalan Remaja
Authors: Rahayu Sri , Sartika Ika , Liawati Euis
Published: October 2023

Semakin maraknya pemberitaan negatif tentang kenakalan remaja  peserta didik sekolah menengah membutuhkan penanganan yang serius guna menjaga citra lembaga pendidikan. SMA YPHB mengalami krisis akibat berita negatif tentang tawuran. Penelitian ini bertujuan untuk mengetahui bagaimana implementasi komunikasi krisis dan penggunaan media social yang dilakukan oleh Humas  dalam menangani pemberitaan negatif peserta didik. Jenis penelitian adalah kualitatif deskriptif dengan tipe penelitian studi kasus dengan menggunakan snownall sampling sebagai pemilihan 11 informan. Teknik pengumpulan data menggunakan wawancara, dokumentasi, dan tinjauan literatur. Peneliti menggunakan model analisis Miles dan Huberman untuk menganalisis data dan melakukan triangulasi untuk memeriksa validitas data. Hasil penelitian menunjukkan langkah-langkah manajemen krisis yang dilakukan SMA YPHB  dengan  identifikasi, analisis, isolasi, strategi dan program pengendalian.  Setiap kegiatan di sekolah dipublikasikan  dengan mengunakan media sosial  (Instagram, Twitter, Facebook, tiktok dan kanal youtube YPHB Channel ). Kehumasan yang lebih terbuka dan manajemen krisis  membuahkan hasil yaitu pemberitaan yang lebih seimbang . Dalam memberikan informasi kepada media, hasil penelitian juga menunjukkan bahwa YPHB telah memberikan informasi secara jujur, konsisten, dan relatif cepat.
Panhellenizmin Kölelik Boyutu
Authors: Yalazı Esra
Published: October 2023

Homēros’tan itibaren Yunan yazarlarca kanonlaştırılan Hellenler ve barbarlar
arasındaki farklılık diyalektiğinin nesnesi olan barbaros kavramının Hellenlerin milli
benliklerini algılamaları için bir ayna işlevi gördüğü öteden beri dillendirilmektedir. Ancak
Hellenlerin askeri başarılarının övülmesi bağlamında öne çıkan Panhellenizm’in, Hellenlerin
üstünlüğü mitini sadece kolonileşme hareketleri için değil aynı zamanda sosyal ve ekonomik
düzenlerinin sürdürülebilmesi için gereken köleliğin meşrulaştırılması için kullanmış olduğu
gerçeğinin akademik camiada göz ardı edildiği görülmektedir. Barbar retoriği Hellenlerin
Perslere karşı askeri üstünlüğünün vurgulanmasına hizmet etmiş olmakla birlikte, aslında
Solōn’un reformları ile yurttaşların borçları karşılığında köle olmaları önlenince dışarıdan
getirilen kölelerin idare edilmesine yarayan ideolojik bir söylem olarak daha önce ortaya
çıkmıştı. Çalışmada kökünü Homēros’tan alan farklılık diyalektiğinin klasik dönem
eserlerinde Perslere karşı yeniden kullanılarak barbaros kavramının nasıl ortaya çıktığı
gösterilmiştir. Bununla birlikte Yunan kentlerindeki sosyolojik gelişmeler sayesinde oldukça
büyük bir barbar nüfusun Hellen zenginliği ve üstünlüğünü yaratmak için kullanıldığı ve
Hellen askeri başarılarının Perslerden esir olarak köle elde etmeğe hizmet ettiği görülmüştür.
Bu doğrultuda çalışmamızda Panhellenizm’in arka planında başta Atina olmak üzere Yunan
kentlerinin köle ihtiyacını karşılama amacının bulunduğu irdelenmektedir.
Anahtar Kavramlar: Panhellenizm, Hellenler, barbarlar, kölelik
Pengembangan Media Pembelajaran Flipbook Digital Panduan Praktikum Sequence Of Service Pada Mata Kuliah Tata Hidang
Authors: Prisila Eliana , Riska Nur , Kandriasari Annis
Published: October 2023

The aim of this study is to develop a digital flipbook practikum guide of the sequence of service on course food and beverage service. Digital flipbook practical guide is much needed in practical learning because it contains multimedia elements which can be used personally by college students. This media is developed by research and development (RnD) method, employing 4D Thiagarajan, Semmel and Semmel 1974 model. The stages of this RnD study are define, design, develop, and desseminate. The result of this learning media consist 3 part is preliminary, core, and closing. this media has been validated by material expert and media expert, they value 82% for material which mean that it is very feasible and 88% for media which mean that it is very feasible. the average score of both this validation is 85% which is fall category very feasible. So it can be concluded that the digital flipbook practikum guide of the sequence of service is very feasible on course food and beverage service
Swyer Syndrome: An in-Depth Exploration of Phenotypic and Genotypic Features in 46, XY Disorders of Sex Development
Authors:   Universidad Autónoma de Guadalajara, Guadalajara, Jalisco. México., Dávila Báez Daniela Alejandra , Valadez García Valeria Macías ,   Universidad Autónoma de Aguascalientes, Aguascalientes. México., Montoya Luis Enrique Morales ,   Universidad autónoma de Sinaloa, Culiacán, Sinaloa. México., Hernández Onassis Armando Prado ,   Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco. México., Campos Canelo Maria Guadalupe ,   Universidad de Guanajuato, Guanajuato. México., Nucamendi Leonardo Ramirez ,   Universidad Autónoma de Guadalajara, Guadalajara, Jalisco. México
Published: October 2023

Swyer Syndrome, also known as 46, XY Complete Gonadal Dysgenesis, is a rare and intriguing disorder of sexual development characterized by a phenotypic female appearance in individuals possessing a 46,XY karyotype. This enigmatic condition results from a cascade of genetic and hormonal events, which ultimately lead to the absence of functional gonads, presenting a challenging diagnostic and therapeutic conundrum. In this comprehensive review, we delve into the intricate landscape of Swyer syndrome, elucidating its genetic underpinnings, clinical manifestations, diagnostic approaches, and contemporary management strategies. By consolidating current knowledge, this article aims to provide a valuable resource for healthcare professionals, geneticists, and researchers interested in unraveling the complexities of disorders of sex development and the genetic determinants of sexual differentiation.
Histological Evaluation of the Effect of Clopidogrel (Plavix) on the Brain, Liver, and Kidney: Histopathology Study
Authors:   General Directorate of Education-Balad Education Department, Saladin, Iraq., Mohammed Yaseen K. , Hamad Hind T. ,   Department of Medical Laboratory Technologies, Al-Dour Technical Institute, Northern Technical University, Saladin, Iraq.
Published: October 2023

Clopidogrel is a prodrug that is absorbed in the intestines and 85% of it is metabolized in the liver, while 15% is the active part of the drug as it works to inhibit platelet aggregation and thus not forming a blood clot. The current study aims to evaluate the histological effect of Clopidogrel on the tissues of the, brain, liver and kidney. Experiment design: The experiment included fifteen albino rats divided randomly into three groups and each group included five animals . The first group was considered the control group. It was received tap water and natural food. As for the second group, the animals were received 15 mg/kg of Clopidogrel once a day with water and food, while the animals of the third group were received 20 mg/kg of Clopidogrel once a day with water and food. The experiment lasted for a month. After the end of the experiment, the animals were anesthetized, and the organs were surgically obtained, and the organs were placed in a 10% formalin solution, and then the tissue preparation techniques were applied to them. Results: The results of the study showed that a drug had several effects in tissues, including atrophy, caseous necrosis, apoptosis of some cells, foamaus appearance, inflammation, and degradation of other cells.
A Comprehensive Review on Role of Polymers in Transdermal Drug Delivery System
Authors:   Assistant professor, Department of pharmaceutics, CMR College of pharmacy, Telangana, Hyderabad., Swarnalatha K. Mary , Saikiran CH. ,   Department of pharmaceutics, CMR College of pharmacy, Telangana, Hyderabad., Mounika B. ,   Department of pharmaceutics, CMR College of pharmacy, Telangana, Hyderabad., Swetha B. ,   Department of pharmaceutics, CMR College of pharmacy, Telangana, Hyderabad., Ramarao T. ,   Principal, Department of pharmaceutics, CMR College of pharmacy, Telangana, Hyderabad.
Published: October 2023

Transdermal drug delivery system has been emerged as one of the most effective controlled drug release system in topical formulation as it doesn’t undergo first pass metabolism in liver and can be directly absorbed into the systemic circulation. Polymers are used in TDDS as to increase its effectiveness in the control release of drug from the transdermal patch. Use of polymers in the TDDS has decreased the control release rate of drug from the patch. Use of polymers in combination has given more effectiveness of the drug release. This article gives a quality of information about the use of polymers in the Transdermal drug delivery system. Polymers also help in the adhesive nature of the drug to the skin and promote more extent of drug release from the dosage form. An advance in the use and amount of polymers used in the TDDS has been increased recently. This article provides the information about the use of Natural, semisynthetic and synthetic polymers in the TDDS. Use of natural polymers has been showed more impact in the TDDS and their use has showed fewer side effects like irritation, allergy, and this has been increased patient compliance and more effectiveness in drug release. Semisynthetic and synthetic polymers has been developed and used excessively in the TDDS for effective control release of the drug from the patches. A transdermal patch is defined as medicated adhesive patch which is placed above the skin to deliver a pre-determined dose of medication via skin with a predetermined rate of release to reach into the bloodstream. Article Details
The Facets and Emotional Connotations of the Love-related Proverbs in Indonesian
Authors:   Sanata Dharma University, DI Yogyakarta, Indonesia, 55002, Nugraha Danang Satria
Published: October 2023

This study explores the intricate aspects of love expressed in Indonesian proverbs through a combination of Cognitive Semantics Analysis (CSA) and Qualitative Method (QM). Analyzing a diverse range of proverbs aims to uncover the nuanced dimensions of love as expressed through linguistic and cultural perspectives. Through the CSA lens, the investigation delves into the underlying cognitive structures that shape the conceptualization of love in these proverbs. The QM complements the study, providing insights into the socio-cultural context and subtle variations in meaning. Specifically, the findings show these three folds. First, love is conceptualized through a range of metaphors such as “love is a journey,” “love is a fire,” and “love is a gift.” Second, In Indonesia, where collectivism is highly valued, family values and communal harmony are paramount. Love proverbs are often associated with familial relationships and the responsibility of providing for one’s family. Lastly, the interplay between cognitive insights and socio-cultural contexts results in a comprehensive understanding of love’s profound representation and importance within Indonesian proverbs, highlighting the interconnectivity between emotions, language, and culture. The outcome of this study offers a deeper insight into the Indonesian culture and language’s conceptualization of love, highlighting the complex interplay between language, culture, and cognition.
Analysis of Employee Engagement with Transformational Leadership and Organizational Climate as Predictors
Authors:   Management Study Program, Universitas Jenderal Achmad Yani, Indonesia, Romi Mochamad Vrans , Efendi Efendi ,   Management Science Study Program, Sekolah Tinggi Ilmu Ekonomi Sultan Agung, Indonesia, Chandra Erbin ,   Management Study Program, Sekolah Tinggi Ilmu Ekonomi Sultan Agung, Indonesia, Candra Vivi ,   Management Study Program, Sekolah Tinggi Ilmu Ekonomi Sultan Agung, Indonesia, Sudirman Acai ,   Management Study Program, Sekolah Tinggi Ilmu Ekonomi Sultan Agung, Indonesia
Published: October 2023

Employees who have a high level of work engagement will show their best performance; this is because these employees enjoy the work they do. When employees are attached to a company, employees have an awareness of the business. The main objective of this research is to analyze the influence of transformational leadership and organizational climate on employee engagement. The research methods include library and field research designs with a quantitative approach. The number of samples analyzed was 140 employees. This study uses a research instrument test consisting of validity and reliability tests. The quantitative analysis consists of a normality test, regression test, hypothesis test, correlation test, and coefficient of determination. The results of the data analysis conclude that transformational leadership, organizational climate, and employee engagement positively and significantly influence innovative work behavior. The results of further research confirm that transformational leadership and organizational climate significantly affect employee engagement. The research conclusion states that by combining transformational leadership and a positive organizational climate, organizations can create an environment where employees feel encouraged to give their best and feel that their contributions positively impact the organization's success. High employee engagement contributes to better productivity, retention, and continued organizational success.
»Zur Belustigung und Belehrung«. Experimentierbücher aus zwei Jahrhunderten.
Authors: Hilz Helmut , Schwedt Georg
Published: October 2023

Dieses umfangreich bebilderte Buch beschäftigt sich mit der Wissenschaftspopularisierung von der Spätaufklärung und Klassik im 18./19. Jahrhundert bis zur Experimentierbuchliteratur im 20. Jahrhundert. Hermann Römpp und seinen chemischen Experimentierbüchern sowie Wilhelm Fröhlich und seinen Experimentierkästen sind eigene Kapitel gewidmet. Katalog zur Ausstellung im Foyer der Bibliothek des Deutschen Museums vom 22.11.2002 bis 28.02.2003. Inhalt: Experimentierbücher – Schlüssel zur Popularisierung der Naturwissenschaften; Frühe Experimentierbücher: »Zur Belustigung und Belehrung«; Physik und Chemie als Naturlehre; Chemische Experimentierbücher; Hermann Römpp und seine Experimentierbücher; Wilhelm Fröhlich und seine Experimentierkästen; Experimente für junge Techniker; Biologische Experimente unter dem Mikroskop; Experimentierbücher heute.
The Government Legal Warranty for Consumers in The Purchase of Property in Indonesia
Authors: Subekti Subekti , Sidarta Dudik Djaja , Marwiyah Siti , Suyanto Suyanto , Ismail Nazli Bin
Published: October 2023

Introduction: The sale and purchase of houses between developers and buyers often result default, which detrimental to consumers. The state has issued various policies regarding buying and selling houses and legal guarantees for buying and selling houses, but violations still occur and there is no legal guarantee from the state but must be resolved through litigation.Purposes of the Research: The purpose of this study is to analyze and find problems with house sale and purchase contracts based on the Sale and Purchase AgreementMethods of the Research: The method used in this research is normative juridical. The research used is library research. The basis used in this research is the juridical basis consisting of Law Number 1 of 2011, GovernmentRegulation Number 12 of 2021. Results of the Research: When the state issues permits to operate housing to developers, the state has provided a legal guarantee to protect its people. Due to the guarantees that have given by the Government through statutory regulations and consumers following the instructions, they are guaranteed to receive legal protection from the state, State Administrative Officials, in terms of granting permits they have gone through applicable legal procedures, if it is proven otherwise then the government must be responsible for the decision. State Administration. However, if there is a violation of the law by the developer, it will difficult for home buyers to claim losses. Experienced, meaning that at the implementation level there is no guarantee for buyers from the state.
Adolescent tennis players' injury profile and awareness level of sports injury
Authors: Abdioğlu Mekki , Güler Melek , Mor Ahmet , Harput Gülcan
Published: October 2023

Objective: The aim of this study is to examine the relationship between injury risk profile and injury awareness, as well as the level of injury knowledge and the incidence of injuries among adolescent tennis players.

Material and Methods: One hundred seventy-nine adolescent tennis players (n: 98 females and 81 males, age: 13.9±1.6 years), who had a history of at least one sports injury were included in the study. A questionnaire was designed by sport experts that questioned about the tennis injuries and awareness of tennis injuries.

Results: The most injured area was the shoulder (22%). It was followed by elbow (19%), ankle (17%), wrist (16%), and the knee (12%). Experiencing more sport injuries (more than twice) increased 5.7 times (p<0.01) if they had medium knowledge level, and increased 22.4 times if they had low knowledge level (p<0.001).

Conclusion: Upper extremity injuries are more common in adolescent tennis players comparing with lower extremity injuries. In addition, the number of previous tennis injuries was related to training load and the athletes' awareness of tennis injuries. Therefore, optimizing tennis training load and increasing the level of injury awareness in adolescent tennis players may be important in preventing future sports injuries.
The Right to Health And Barriers to Health Services for Refugees and Internally Displaced Persons: Review of Foreign Literature
Authors: Dobrieva Anzhelika I. , Ananchenkova Polina I.
Published: October 2023

All over the world, the number of people forced to flee their homes due to conflict, violence, and persecution is now higher than at any time in human history. Migrants, refugees, and other citizens belonging to the category of internally displaced persons have the right to health and medical care in the host country based upon the basic principles of humanitarian law and a number of international legal documents. However, the practice of providing medical care in the host country varies depending on the legislation and resources of the national healthcare system.
The purpose of this study was to consider the barriers to the accessibility of medical care for migrants, refugees, and other internally displaced persons.
Challenges and prospects for health workforce management
Authors: Burdastova Yulia V.
Published: October 2023

The key to building an effective healthcare system is to provide highquality treatment, take measures for disease prevention, and make medical care more accessible for all population groups. Today, the Russian healthcare system has a lot of serious issues in human resources management that require urgent solutions.
Concept of Reference Diagnostics as the Foundation for Developing Diagnostic Algorithm to Support Doctor’s Decision-Making
Authors: Yakushin Mikhail A. , Vorobeva Anna V. , Vasiliev Mikhail D. , Kudrin Alexey P. , Yakushina Tatyana I. , Arseenkova Olga Yu.
Published: October 2023

The article analyzes current conceptual approaches to developing algorithms for supporting doctor's de-cision-making process. The need for application of sorting algorithms to generate decision-supporting algo-rithms is explained. We suggest a concept of reference diagnostics based on systematization of topical and nosological series that determine the direction and sequence of diagnostic process. According to the concept, each possible pathological region localization and each disease are presented as a set of positive and negative reference signs. In order to demonstrate the sequence of diagnostic algorithm elaboration, a specific neuro-logical pathology is used as an example. The prospects for the practical application of reference diagnostics in clinical medicine are defined.
Psychogenic Erectile Dysfunction: A Multidisciplinary Problem
Authors: Vasiliev Alexander O. , Astakhov Nikita V. , Arutyunyan Pavel A. , Aliev Oleg R. , Ходырева Любовь Алексеевна , Pushkar Dmitry Yu.
Published: October 2023

Erectile dysfunction is a multifactorial problem that requires various treatment approaches based on the factors affecting disease development. Erectile dysfunction is one of the most serious clinical and social is-sues among men. It’s obvious that a full sexual life is one of the most important components of physical and mental health. Recent sociological data show that sexual health is the key not only to a good quality of life, but also to a longer life expectancy. It is noted that combining the traditional three-stage therapy – oral drugs, penile injection therapy and penile implantation – with ongoing psychotherapy can significantly improve the treatment results. Accordingly, it becomes important and crucial for a specialist to be aware of the timely referral of a patient to a psychotherapist.
Modern Crisis Phenomena and Its Impact on the Development of Small and Medium-Sized Enterprises
Authors: Petrova Galina D. , Kheyfets Mikhail I.
Published: October 2023

Introduction. The segment of small and medium-sized enterprises is one of the top priorities for the strategy of economic development of the Russian Federation. Thus, studies on this topic seem to be relevant. The share of small and medium-sized entrepreneurship (SMEs) in the GDP of developed countries ranges from 35 to 65 %, while the share of SMEs in the GDP of the Russian Federation still does not exceed 20 %.
The current challenges affecting the economy of the Russian Federation, including the COVID-19 pandemic and the current geopolitical situation, as well as sanctions against the Russian Federation imposed by other countries, have had a significant negative impact on small and medium-sized enterprises.
Purpose of the study. The purpose of this study was to review and analyze current crisis phenomena and its impact on the development of importing companies from the SME segment in order to identify key areas requiring the development of new approaches to crisis management.
Results and conclusion. Study results show that modern crisis phenomena have had a significant impact on the development of the SME segment, thus forming a completely new market environment. New challenges have affected almost all activity areas of importing companies from the SME segment from the internal management policy (organization of the company's activities and personnel management) to the rules for importing goods, including logistics, calculations, value management, etc.
Analisis Faktor-Faktor yang Mempengaruhi Pendapatan Nelayan Jaring Insang Dasar di Desa Lawulo, Kecamatan Samaturu, Kabupaten Kolaka
Authors: Saleh Ramlah , Amin Muhtar , Prihantini Campina Illa
Published: October 2023

Kolaka Regency is one of the fisheries producers in Southeast Sulawesi Province. The economic value of capture fisheries in Kolaka Regency also continues to increase from year to year. Unfortunately, this increase is not followed by an improvement in the economy of small-scale fishermen. Many factors influence this. One of them is the still high practice of using simple fishing gear and the management of fisheries businesses that are not yet qualified. Lawulo Village has people whose main livelihood is fishing. In general, they use gill nets in their capture fisheries business. This study uses multiple linear regression analysis intending to know the factors that influence the income level of gillnet fishermen. The data used is primary data obtained from interviews with fishermen. The results showed that four factors significantly influenced the income level of basic gillnet fishermen, namely age and education level. The variable number of family dependents and business experience did not significantly affect the income received by fishermen.
Xác định các chỉ số đánh giá an toàn hệ thống tín hiệu điều khiển chạy tàu hiện đại
Authors: Nguyễn Duy Việt , Trịnh Thị Hương , Trịnh Văn Mỹ , Vũ Trọng Thuật
Published: October 2023

Nhiệm vụ đánh giá an toàn một hệ thống tín hiệu điều khiển chạy tàu là nhiệm vụ không thể thiếu đối với bất cứ hệ thống vận tải đường sắt nào. Sự xuất hiện hệ thống tín hiệu điều khiển chạy tàu với công nghệ hiện đại ngày nay trên cơ sở máy tính và mạng máy tính sẽ cần có được phương pháp đánh giá an toàn mới. Hệ thống tín hiệu điều khiển chạy tàu được phân tích từ sự cần thiết, chức năng hoạt động, đặc điểm cấu trúc, nền tảng công nghệ để đưa ra mô hình chung nhất của hệ thống. Phân tích các lỗi có thể của hệ thống tín hiệu điều khiển chạy tàu dẫn tới các sự kiện bất ổn định, bất ổn định nguy hiểm để đưa ra mô hình đánh giá an toàn, từ đó hình thành được những khái niệm, những chỉ số an toàn, rủi ro đầy đủ cho hệ thống. Việc xác định đầy đủ các chỉ số an toàn, rủi ro cho một hệ thống tín hiệu điều khiển chạy tàu hiện đại sẽ là cơ sở để cho những nghiên cứu tiếp theo, tìm ra những phương pháp định lượng cho từng chỉ số, phục vụ đánh giá, quản lý vận hành, thiết kế hệ thống tín hiệu điều khiển chạy tàu với các giải pháp đảm bảo an toàn chạy tàu
Çocukların İktisadi Kavramları ve Sistemleri Anlamlandırma Süreçleri
Authors: GÖNÜL Buse
Published: October 2023

Gelişim psikolojisi ve iktisat bilimi gerek yöntem gerek çıktılarının ilişkilendirilmesi aşamasında çok sık kesişmiyor olsa da iktisadi kavram ve sistemleri bireysel düzeyde ele alırken çocuk katılımını da merkeze koyan bir bakış açısı her iki alan için de tamamlayıcı olacaktır. Bu derleme makalesinde, çocukların ekonomik sistemleri ve iktisadi kavramları nasıl anladıkları, finansal okuryazarlığını oluşturan etmenleri ve gelir eşitsizliklerini nasıl ele aldıkları gelişim psikolojisi bakış açısıyla ele alınmaktadır. Para ve diğer ekonomik aktivitelerin kavramsal gelişimi bilişsel, sosyal ve kültürel faktörlerin bir etkileşimini içermektedir. Çocuklar, deneyim, sosyal etkileşimler ile ebeveynler ve akranlar gibi bilgi kaynakları aracılığıyla ekonomik sistemleri anlamlandırmaya başlarlar ve bu bilgileri sosyal hayatlarında uygularlar. Bu nedenle, çocukların ekonomik kaynaklara verdikleri anlam ileriki yaşlarda ekonomik sistemleri yorumlamalarında da etkilidir. Bu duruma paralel olarak destekleyici tutumlar ve yaşa uygun öğrenme yöntemleri ile çocukların finansal okuryazarlık becerileri gelişir. Dezavantajlı sosyoekonomik koşullarda yaşayan çocukların ise maruz kaldıkları şartların bir sonucu olarak bu becerileri (bütçe oluşturma, tasarruf yapma gibi) geliştirme zorunluluğu ortaya çıkabilmektedir. Son olarak, sosyal ve ekonomik eşitsizlikler ile kaynakların adaletsiz dağılımı gibi dinamiklerin çocuklar tarafından nasıl algılandığına odaklanılmıştır. Özellikle çocukluktan ergenliğe geçiş döneminde eşitsizliklere karşı duyarlılığın arttığı fakat statükoyu koruyan tutumların da yine bu dönemin özellikleri arasında olduğu gözlemlenmektedir.
BİRİNCİ DALGA RUS GÖÇMEN EDEBİYATINDA TÜRK KADINI İMGESİ
Authors: Erinç Erdem , Bozseki Ahsen
Published: October 2023

Rus göçmen edebiyatı 20. yüzyılda üç ayrı göç dalgasıyla Rusya ve Sovyetler Birliği’nden dünyanın farklı yerlerine iltica eden göçmen yazarların eserlerinin oluşturduğu edebiyattır. Rus göçünün birinci dalgasını Rus İç Savaşı’nın (1918-1922/1923) doğal bir sonucu olarak Rusya topraklarında kuzeyden güneye ilerleyen askeri ve sivil nüfus oluşturur. Ülkelerini Karadeniz kıyılarındaki şehirlerden terk etmek zorunda kalan birinci dalga Rus göçmenleri için Rusya’nın dışındaki ilk durak İstanbul’dur. Birinci dalgayla İstanbul’a gelen göçmen yazarlar bu şehri gerek olay örgüsünün bir parçası olarak, gerekse eserlerine mekân seçerek kurgu ya da kurgu dışı eserlerine dahil etmişlerdir. İstanbul simgesel anlamlarıyla bu eserlere dahil olurken şehri var eden imgeler de bileşenleriyle birlikte Rus göçmen edebiyatı metinlerinde yerlerini almıştır. İmgeler arasında Boğaziçi, Ayasofya gibi sabit şehir imgeleri kadar insanlar ve mekânların buluşmasıyla örülmüş sosyal imgeler ve onların bileşenleri de bulunur. Rus göçmen edebiyatının birinci dalgasına mensup, göç yolu İstanbul’dan geçmiş yazarların eserlerinde Türk kadınının temsili bu çalışmanın konusunu oluşturur. Çalışmada Nadejda Teffi, Arkadi Averçenko, Aleksandr Vertinski ve Zinaida Şahovskaya gibi yazarların İstanbul ve Türk kadınını konu ettikleri eserlerinden oluşturulan örneklem ile göçmen edebiyatının Türk kadınını kendi söyleminde nasıl tanımladığını göstermek amaçlanmıştır. Edward Said’in Oryantalizm kuramı ve bu kurama getirilen yeni yaklaşımlarla Rus göçmen edebiyatı metinleri değerlendirilmiştir. Değerlendirme Batı’nın Doğu’yu bir bütün halinde ele alarak ona dair genellemelerle edebiyat ve sanat üzerinden meşruiyet kazandırdığı harem, çarşaf gibi imgeler ve onların bileşenlerinin sınıflandırılmalarıyla gerçekleştirilmiştir. Klasik oryantal klişelerin Rus edebiyatını etkilediği kadar göçmen edebiyatında da belirli bir etkisi olduğu görülmüştür. Rus göçmen edebiyatında Türk kadını imgesini ortaya koymak, Batı’nın Doğu’ya karşı geliştirdiği oryantalist söylemin Rus göçmen edebiyatındaki karşılığını görmeyi sağlamıştır.
La arquitectura funcional de Fernández Casado: la Sociedad Ibérica del Nitrógeno en Langreo
Authors: Redondo González Lara , Lázaro San José Laura María
Published: October 2023

El conjunto de la Sociedad Ibérica del Nitrógeno (1950-1997) se constituye durante las décadas de los sesenta y los setenta como uno de los principales motores económicos de Asturias. Su modernidad en cuanto a instalaciones y tecnología, así como el hecho de partir de un proyecto global, hacen que se reconozca como un foco de innovación referente. Sin embargo, tras su cierre y con el paso del tiempo se ha convertido en un lugar olvidado. Este artículo se propone analizar e interpretar el proceso de diseño y construcción de este proyecto desde la perspectiva y los medios actuales, como ejemplo de conjunto arquitectónico-industrial moderno diseñado en su totalidad en base a cuestiones funcionales. A través de la interpretación crítica de su composición original y la elaboración de nueva documentación gráfica, se contribuye al reconocimiento de los factores de una estética concreta y común en la obra del ingeniero Carlos Fernández Casado, al mismo tiempo que se identifican las singularidades que caracterizan este caso. Con todo ello, se pretende la traducción de un ejemplo actualmente ilegible debido a décadas de abandono y desmantelamiento, generando argumentos a favor de su puesta en valor como hito paisajístico, patrimonial e identitario de este territorio.
La arquitectura importa
Authors: Hoidn Barbara
Published: October 2023

Fue sorprendente e inquietante para el discurso arquitectónico europeo e internacional que, alrededor de la década de 1990, una joven generación de arquitectos brasileños se ganó el respeto y la atención internacional. Este grupo de arquitectos presentó proyectos con un considerable impulso para el urbanismo contemporáneo que no existían en el orden canónico del viejo mundo a causa de un pesimismo saturado y revisionista. En la tristemente célebre y confusa megalópolis paulista, como en muchas otras ciudades sudamericanas tras el fin de las respectivas dictaduras, la arquitectura se convirtió en una forma de crítica política construida, un medio de expresión que visibilizaba los déficits urbanos y, al mismo tiempo, los cambiaba programáticamente, mostrando de este modo, vías de salida de la crisis hacia una ciudad mejor. Los arquitectos Cristiane Muniz y Fernando Viégas, cofundadores de UNA Arquitetos (Cristiane Muniz, Fábio Valentim, Fernanda Barbara, Fernando Viégas, Ana Paula Pontes y Catherine Otondo), hoy UNA MUNIZVIÉGAS, desempeñaron un papel clave en este contexto. Desde 2005, cuando nuestros caminos se cruzaron por primera vez, sigo su trayectoria profesional con admiración, curiosidad y expectación.
Entre otros
Authors: Muniz Cristiane , Viégas Fernando
Published: October 2023

Entender y revelar nuestro lugar en el mundo, tanto geográfica como culturalmente, es una de las razones del trabajo que realizamos día a día. Brasil es un país de escala continental donde prácticamente todos hablan el mismo idioma, pero que sin embargo aún conserva más de doscientas lenguas nativas que son un patrimonio cultural vivo. Es, por tanto, una obligación proteger esas comunidades y preservar ese legado. Somos el único país de América que habla portugués, hecho que, de cierta manera, nos aísla entre el Océano Atlántico y la Cordillera de los Andes. Como si estuviéramos entreAmérica Latina, Europa y África. Creemos que nuestra arquitectura refleja esa posición en varios sentidos. La especialidad, inclusive en proyectos de pequeña escala, incorpora la presencia de ese vasto territorio como cultura, su fauna y flora.
2001-2008. Construcciones Rurales en Joanópolis
Authors: UNA arquitetos
Published: October 2023

La Casa Joanópolis se proyecta para amigos que frecuentan la Finca Carambó, a dos kilómetros de distancia, donde construimos un quincho en 2002. La región es el inicio de la Sierra de la Mantiqueira, con mil metros de altitud, en la divisa entre São Paulo y Minas Gerais. El conjunto de casas queda al margen de la represa de Piracaia, que integra el sistema de suministro de la capital. Cercano, el barrio del Lopo, antiguo camino de Bandeirantes y parada de troperos del siglo XIX.
El Pabellón Carambó se construye en la Finca Carambó, ubicada en la frontera de los estados de São Paulo y Minas Gerais, cerca de la ciudad de Joanópolis ubicada a 1000 metros de altitud en la Serra da Mantiqueira. La finca se encuentra localizada en un gran valle de pastos cuyas montañas circundantes están cubiertas en su parte superior por un bosque nativo. En ella ya existía una casa, construida sobre una meseta en el nivel intermedio entre la cumbre y el fondo del valle. Se trata de una reconstrucción de un antiguo caserón del barrio de Lopo, parada de arrieros del siglo XIX, y que iba a ser demolida.
2012-2017. Casa en Cotia
Authors: UNA arquitetos
Published: October 2023

El diseño de una casa siempre presupone asumir el compromiso de albergar las relaciones de una familia. Ambientar la infancia, la jornada de la vida, y estabelecer las escalas de medida para el mundo. Al mismo tiempo, el proyecto se entiende como un ensayo, una posibilidad de muchas otras construcciones. Éste, en particular, busca reforzar el caminar, el paseo como forma de percepción del lugar. Tiempos que conviven. La amplia parcela en esquina, ya poseía arborización densa, opuesta a la alameda de acceso, donde había un claro. Así pues, la implantación aprovecha esa área libre, resguarda a sus habitantes de los ruidos de la calle y se abre a un pequeño bosque. El desafío es construir un nuevo terreno ampliando sus cualidades. La construcción, en sección, se acomoda a la geografía, territorio paulista de pequeños cerros. El espacio en planta permite la integración entre el interior y exterior, que se alternan, se doblan y se complementan con agua, fuego, vegetación. Cuatro planos construidos a partir de tres muros de contención paralelos organizan el paisaje.
2019-2021. Casa Juquiá
Authors: UNA MUNIZVIEGAS
Published: October 2023

Imaginemos que quien construye una casa en São Paulo busca diluir los límites entre espacios abiertos y cerrados, adentro y afuera, cubiertos y descubiertos, aprovechando nuestro clima. El proyecto interpreta este deseo en una parcela de diez metros de ancho, típica del simpático barrio Jardim Paulistano, un lugar privilegiado de la ciudad con comercio, servicios, arbolado e infraestructura. El diseño pretende rodear la casa de jardines, terrazas y balcones que se extienden hacia los interiores formando un entorno único. La operación principal es disponer la construcción longitudinalmente sobre el terreno, de forma lineal, manteniendo la mitad del ancho libre con cinco metros. Así, la vegetación se encuentra en la parte norte, asegurando un retiro para la luz solar y la aireación permanente de la casa que se apoya en el borde opuesto. La parcela se expande, quedando libre la mayor longitud, reforzando esta percepción de amplitud con balcones, patios y la transparencia de la sala.
Concepções e práticas de promoção da saúde segundo acadêmicos de odontologia em Santa Catarina - Brasil - doi: 10.5020/18061230.2012.p321
Authors: Campos Luciane de , Carniel Ricardo de , Azambuja Gregory Hacke , Bottan Elisabete Rabaldo
Published: October 2023

Investigar concepções, práticas e conhecimentos de promoção da saúde de acadêmicos dos cursos de Odontologia em Santa Catarina, Brasil. Métodos: Esta investigação foi um estudo descritivo com abordagem qualitativa, mediante levantamento de dados primários. A população-alvo foi constituída por discentes de cursos de odontologia do estado de Santa Catarina. A amostra foi composta por 148 acadêmicos ingressantes e 122 acadêmicos concluintes. Os dados foram coletados por meio da aplicação de uma entrevista semiestruturada. Para a análise, utilizaram-se os princípios da Análise de Conteúdo. Resultados: As concepções de promoção à saúde, evidenciadas pelos ingressantes e concluintes, foram: autocuidado/qualidade de vida (37,3% e 19,4%) desenvolvimento de aptidões pessoais (18,4% e 34,6%), políticas públicas saudáveis (3,8% e 3,5%), reforço da ação comunitária (7,4% e 7,3%), reorientação do serviço de saúde (11,3% e 12,4%) e prevenção/tratamento (21,5% e 23,7%). Como práticas de promoção em saúde, os ingressantes e concluintes citaram: desenvolvimento de aptidões pessoais (36,2% e 47,1%), prevenção e tratamento (38,4% e 35,3%), criação de ambientes saudáveis (16,5% e 4,7%), reforço da ação comunitária 6,7% e 6,7%), reorientação dos serviços de saúde (1,3% e 5,1%) e políticas públicas saudáveis (0,9% e 1,2%). Conclusão: Uma parcela dos sujeitos da pesquisa tem concepções e práticas de promoção da saúde ligadas à atuação curativopreventiva, o que representa um equívoco. Uma parcela expressiva dos entrevistados citou concepções e práticas mais coerentes com a promoção, o que pode indicar um momento de transição no qual o modelo biomédico vai sendo substituído pelo modelo da promoção à saúde.
Sensing the Spirit
Authors: Merkle Judith A.
Published: October 2023

Drawing on the work of Canadian philosopher Charles Taylor this book examines how secular culture affects both the living of Christian discipleship today and impacts how religious congregations engage in their own renewal and future. It argues that religious can do more than improve and fix the out of date conditions they met in the renewal after Vatican II.

Today they are called to deepen and unfold further potentials by developing new directions and syntheses. Calling on environmental, sociological and theological insights it will ask how the ongoing “coming of the Kingdom” in the Spirit brings new gifts for these times and how congregations might respond beyond restorative or post Christian solutions to new challenges confronting them. This book offers a renewed meaning of religious life in secular life and the gift it offers and receives from every culture in which it is embedded.
Sanctuary and Subjectivity
Authors: Woolf Michael
Published: October 2023

The Sanctuary Movement of the 1980s was a movement led by white religious liberals that housed Central Americans fleeing dictatorships supported by the United States government, giving them a platform to speak about the situation in their countries of origin.

Until now, much scholarship has focused on the movement’s white activists, but this book centers the experiences of recipients of sanctuary to produce an account of the movement that takes seriously its whiteness, the agential limitations of sanctuary, and the struggles for agency by recipients.

Using interviews with participants in the movement, this book situates the movement as site for theological reflection on some of the most pressing issues facing the Church today – the possibilities of testimony, the Holy Spirit, ecclesiology, and mercy. In doing so, it proposes a new theoretical framework for thinking about practice by introducing readers to Judith Butler’s theories of subjectivation and arguing for ethnographically engaged theology that is able to think beyond virtue and excellence towards an understanding of fugitivity.