bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Photochemistry of 4‐Acyloxy‐2‐azabuta‐1,3‐dienes. A Novel Photochemical 1,2‐Acyl Migration in an Enol Ester.
Authors: ARMESTO D. , ORTIZ M. J. , PEREZ‐OSSORIO R. , HORSPOOL W. M.
Published: May 2016

The acyloxy‐azabutadienes (I), on irradiation, undergo rearrangement by 1,2‐migration of the acyl group to yield the 2,5‐dihydro‐oxazoles (II), which are found to be the sole products of this photoreaction.
ChemInform Abstract: Studies on 2,3‐Disubstituted Thiazolin‐4‐one.
Authors: ELBANNANY A. A. A. , IBRAHIM A. A. H.
Published: May 2016

Die aus den Iminen (I) zugänglichen Thiazolinone (III) liefern in Folgereaktionen die Heterocyclen (V), (VIII) und (XI).
ChemInform Abstract: Ring Contraction of 1,2,6‐Thiadiazines to 1,2,5‐Thiadiazoles: Synthesis of 2‐Substituted 4‐Amino‐2,3‐dihydro‐3‐oxo‐1,2,5‐thiadiazole 1,1‐Dioxides.
Authors: ARAN V. J. , BIELSA A. G. , RUIZ J. R. , STUD M.
Published: May 2016

Die Sulfamide (I) addieren Malonylchlorid (II) unter Bildung der Dioxide (III), von denen sich (IIIa), (IIIb) und (IIId) zu den Derivaten (IV) nitrosieren lassen.
ChemInform Abstract: Fused Thiopyrones. Part 2. 2‐Carboxylic Acids of Thiopyrano[3,2‐b]indol‐4(5H)‐one and Thiopyrano[2,3‐b]indol‐4(9H)‐one.
Authors: GOERLITZER K. + , HOELSCHER D. +
Published: May 2016

Die Indolylthiofumarsäuren (I) cyclisieren beim Erhitzen mit Polyphosphorsäure in Eisessig zu Gemischen der im Titel genannten Carbonsäuren (II) und (III), die als Methylester getrennt und durch nachfolgende alkalische Hydrolyse in reiner Form erhalten werden.
ChemInform Abstract: Stereochemistry of 3‐Oxo‐5‐phenylcyclopentanecarboxylic Acids.
Authors: BECK M. , FRAHM A. W.
Published: May 2016

Die aus den Pyri‐ di‐naldehyden (I) über Wittig‐Reaktion zugänglichen Azazimtsäureester (I‐II‐) reagieren mit dem Triester (IV) unter basischen Bedingungen in einer gekopbe?lten Michael‐ und Dieckmann‐Reaktion zu den Cyclopentanonestern (V), die beim sauren Abbau stereoselektiv die cis‐ Carbonsäuren (VI) liefern.
ChemInform Abstract: Studies on the Synthesis of 3‐Amino‐5‐(4‐pyridinyl)‐1,2‐dihydropyrid‐2‐ one (Cordemcura) from a Technical Mixture of Alkyl Pyridines.
Authors: NIEDRICH H. , HEYNE H. U. , SCHROETTER E. + , JAENSCH H.‐J. + , HEIDRICH H.‐J. , FAUST G. , LOHMANN D.
Published: May 2016

Der Vilsmeier‐Komplex aus Phosgen und Dimethylformamid liefert mit 4‐Picolin (I) die Verbindung (II).
ChemInform Abstract: Acetamidacetal Cyclization. Part 2. 2‐Aminoquinolines and Pyrrolo‐[2,3‐b]quinolines.
Authors: EIDEN F. , BERNDL K.
Published: May 2016

Die Aminobenzophenone (I) kondensieren mit den Amidacetalen (II), (V) bzw. (VII) über die teilweise isolierten Amidine wie (VIII) zu den im Titel genannten Heterocyclen (III), (VI) bzw. (IX).
ChemInform Abstract: Synthesis of 5‐Oxo and 7‐Oxopyrido[2,3‐d]pyrimidines.
Authors: ANDERSON G. L. , RICHARDSON S. G.
Published: May 2016

Der Ester (Ia) wird alkalisch zur Carbonsäure (Ib) verseift und diese thermisch zu (II) decarboxyliert.
ChemInform Abstract: Synthesis of Substituted Thieno[2,3‐d]pyrimidine‐4(3H)‐thiones from Thieno[2,3‐d]‐1,3‐thiazine‐4‐thiones and N‐Nucleophiles by Cyclic Transformation Reactions.
Authors: LEISTNER S. , GUETSCHOW M. + , WAGNER G.
Published: May 2016

Die Umsetzung der Thiazin‐thione (I) mit Ammoniak bzw. den primären Aminen (II) liefert die Pyrimidin‐thione (III).
ChemInform Abstract: Synthesis of Some Substituted 1,2,4‐Triazines.
Authors: MIRONOVICH L. M. , PROMONENKOV V. K. , KRYSIN V. P.
Published: May 2016

Die Nitrosierung der Triazinonthione und ‐dithione (I) ergibt die entsprechenden 4‐Nitrosoderivate (II).
ChemInform Abstract: Muscle Relaxants. Part 4. Monoacylbutyroguanamines.
Authors: KREUTZBERGER A. , LOCH M.
Published: May 2016

Von den aus Butyroguanamin (I) hergestellten Acylderivaten (III) sind (IIIe) muskelrelaxierend bzw. antidiabetisch und (IIIa) trichomonazid und antiviral wirksam.
ChemInform Abstract: Regularities of the Rotational Isomerism of Methyl Substituted Dialkyl‐ and Diarylmethylphosphinoxides.
Authors: PATSANOVSKII I. I. , ISHMAEVA E. A. , SUNDUKOVA E. N. , YARKEVICH A. N. , TSVETKOV E. N.
Published: May 2016

Die aus den Phosphinigsäuren (I) durch Hydroxymethylierung mit Formaldehyd (II) und nachfolgende Chlorierung dargestellten Chlormethylphosphinoxide (IV) werden mit Methylat (Va) und den Phenolaten (Vb) zu den Derivaten (VI) umgesetzt.
ChemInform Abstract: P‐Tert‐Butyl‐ and P‐Mesityl‐N‐[2,4,6‐tri(tert‐butyl)‐phenyl]‐λ3‐imino Phosphines.
Authors: ROMANENKO V. D. , DRAPAILO A. B. , RUBAN A. V. , MARKOVSKII L. N.
Published: May 2016

Auf der Suche nach neuen, zweifach koordinierten Phosphorverbindungen werden die Iminophosphane (IV) auf dem angegebenen Weg erhalten.
ChemInform Abstract: Hydrolytic Decomposition of Quaternary Phosphonium Salts in the 2‐Phenyl‐9‐oxa‐ 2‐phosphabicyclo[4.4.0]decanone Series.
Authors: BUTIN B. M. , ISAEVA G. M. , ERZHANOV K. B.
Published: May 2016

Der früher beschriebene Phosphabicyclus (I) wird mit Methyliodid (II) zu dem Phosphonium‐Salz (III) quaterniert und dieses unter Standardbedingungen zu dem Phosphinoxid (IV) hydrolysiert.
ChemInform Abstract: Addition of Phenylisocyanate to 2‐Phenyl‐1,3,2‐oxazaphosphorinane.
Authors: PUDOVIK M. A. , MIRONOVA T. A. , PUDOVIK A. N.
Published: May 2016

Die im Titel genannte Reaktion liefert den Harnstoff (III).
ChemInform Abstract: The Synthesis of Metallaindene and Metallafluorene Compounds.
Authors: RAUSCH M. D. , KLEMANN L. P. , BOON W. H.
Published: May 2016

Ausgehend von Diphenylacetylen (I) bzw. Dibromdiphenyl (XIII) werden gemäß Schema die Metallaindene (III)‐(V) sowie (XII) bzw. die Metalla?uorene (XIV) und (XV) synthetisiert.
ChemInform Abstract: Some Substituted Urea Complexes of Thorium(IV) and Uranium(IV) N‐Thiocyanates.
Authors: AL‐DAHER A. G. M. , BAGNALL K. W.
Published: May 2016

The Complexes (I) and (II) are prepared by treating the metal tetrachloride or the corresponding complex of the tetrachloride with a stoichiometric amount of potassium thiocyanate and an excess of the ligand in THF.
ChemInform Abstract: Synthesis and Characterization of a Mn(III) Porphyrin Cation Radical and Its Conversion to Mn(IV) by Ligand Metathesis.
Authors: SPREER L. O. , MALIYACKEL A. C. , HOLBROOK S. , OTVOS J. W. , CALVIN M.
Published: May 2016

The complex (Ib) was synthesized by the oxidation of (Ia) with phenoxathiin hexachloroantimonate in CH2Cl2 at room temperature.
ChemInform Abstract: Paramagnetic Cobalt(III) Complexes of Polyanionic Chelating Ligands.
Authors: COLLINS T. J. , RICHMOND T. G. , SANTARSIERO B. D. , TRECO B. G. R. T.
Published: May 2016

The ligand (I) stabilizes Co(III) in the rare square‐planar geometry.
ChemInform Abstract: Distinction of the Two Type I Coppers in Bovine Ceruloplasmin.
Authors: SAKURAI T. , NAKAHARA A.
Published: May 2016

Redox potentials of the two type Icopper ions, "blue copper ions", ofbovine ceruloplasmin (ferroxidase, iron(II): oxygen oxidoreductase) were determined and the reduction and reoxidation properties of each type of copper studied by using absorption, CD and EPR spectroscopy.
ChemInform Abstract: Copper‐Catechol Chemistry. Synthesis, Spectroscopy, and Structure of Bis(3,5‐ditert‐butyl‐o‐semiquinato)copper(II).
Authors: THOMPSON J. S. , CALABRESE J. C.
Published: May 2016

The dimeric title compound (III) with square pyramidal geometry about the metal ion is prepared by reacting of the Cu(I) complexes (I) with the benzoquinone (II) or of the basic Cu(II) dimer (IW with the catechol (V).
ChemInform Abstract: Formation of Electronically Excited Products in Electron‐Transfer Reactions: Reaction of Polypyridine Complexes of Cobalt(I) and Ruthenium(III) in Acetonitrile.
Authors: LIU D. K. , BRUNSCHWIG B. S. , CREUTZ C. , SUTIN N.
Published: May 2016

The yields of the metal‐to‐ligand charge‐transfer excited state of poly(pyridi‐ ‐ ne)‐Ru(II) complexes RuL%+ produced in the reaction of RuLä+ with CoL3+ complexes in acetonitrile are determined.
ChemInform Abstract: Transition Metal Complexes with Terminal or Bridging Imidato(l ‐) Ligands. X‐Ray Crystal Structures of trans‐[Ir(CO)(NCOC2F4CO)(PPh3)2] and [{Pd(o‐C6H4CH=NPh)(μ‐NCOC2H4CO)}2]·CH2Cl2, Spectroscopic Studies of [Mn(CO)5(NCOC2H4CO)], and the Nature of the Metal ‐ Nitrogen Bond.
Authors: ADAMS H. , BAILEY N. A. , BRIGGS T. N. , MCCLEVERTY J. A. , COLQUHOUN H. M. , WILLIAMS D. J.
Published: May 2016

The reaction of Mn(CO)5Br (I) with the Tl(I) salt (II) ofsuccinimide yields the succinimidato complex (III).
ChemInform Abstract: Fluxionality and Bonding in Formamidine and Formamidinate Complexes of Pt(II) and Pd(II) Containing the 2,6‐Bis[(dimethylamino)methyl]phenyl Ligand: A Proton NMR Study with X‐Ray Crystal Structures of [Pt{C6H3(CH2NMe2)2‐2,6}{p‐MeC6H4N = CHN(H)C6H4Me‐p}][CF3SO3] and [Pt{C6H3(CH2NMe2)2‐2,6}(p‐MeC6H4N = CHNC6H4Me‐p)].
Authors: GROVE D. M. , VAN KOTEN G. , UBBELS H. J. C. , VRIEZE K. , NIEMANN L. C. , STAM C. H.
Published: May 2016

The ligand (II) reacts with the ionic species (I) to form the complexes(1II), whose 1H NMR spectra are consistent with a rigid monodentate bonding mode of neutral (II).
ChemInform Abstract: Synthesis and Structural Characterisation of [Pt2Au2(PPh3)4(CNC6H3Me2‐2,6)4][PF6]2; a Platinum ‐ Gold Cluster with a Distorted Butterfly Geometry.
Authors: BRIANT C. E. , GILMOUR D. I. , MINGOS D. M. P.
Published: May 2016

The title compound (IIIb) and its BF4 analogue (IIIa) are prepared by the 1 :l molar reaction of (I) with (II) as shown.
ChemInform Abstract: Reactions of Porphyrins with Nitronium Tetrafluoroborate in Pyridine.
Authors: CAVALEIRO J. A. S. , NEVES M. G. P. M. S. , HEWLINS M. J. E. , JACKSON A. H.
Published: May 2016

The porphyrin (Ia) reacts with (II) in pyridine to afford the meso‐nitro compound (Ib).
ChemInform Abstract: Structures of ent‐Herbertane Sesquiterpenoids Displaying Antifungal Properties from the Liverwort Herberta adunca.
Authors: MATSUO A. , YUKI S. , NAKAYAMA M.
Published: May 2016

The structures of the title compounds (I)‐(VI) are elucidated by degradation reactions and spectroscopic methods.
ChemInform Abstract: Stereoselective Glycosylation of Steroid Alcohols Using 2,3,4,6‐Tetra‐O‐pivaloyl‐ α‐D‐glucopyranosyl Bromide (Pivalobromoglucose) and 2,3,4,6‐Tetra‐O‐(o‐toluoyl)‐ α‐D‐glucopyranosyl Bromide.
Authors: HARREUS A. , KUNZ H.
Published: May 2016

Structurally diverse steroid alcohols of type (I) possessing hydroxylic functions of electronically and sterically different reactivity and, furthermore, including sensitive groups, are effectively and selectively converted into their β‐glycosides (III) using the bromide (II).
ChemInform Abstract: Synthesis of 5‐(β‐D‐Ribofuranosyl)‐1,2,4‐oxadiazole‐3‐carboxamide.
Authors: HENNEN W. J. , ROBINS R. K.
Published: May 2016

Aus den Säurechloriden (I) erhält man mit dem Amidoxim (II) die Oxadiazole (III).
ChemInform Abstract: Ebenaceae Extractives. Part 9. New Naphthoquinones and Binaphthylquinones from Macassar Ebony.
Authors: MAITI B. C. , MUSGRAVE O. C.
Published: May 2016

In addition to the known compounds macassar II and its methyl ether, macassar III, diomelquinone A (I), compound (II), celebaquinone (III), isocelebaquinone (IV), diosindigo B (V) and its dihydro derivative (VI) are isolated from Diospyros celebica Bakh.
ChemInform Abstract: Structure Determination of 8006‐l, a Polyene Antibiotic from Amblyosporium spongiosum.
Authors: KLEVERSAAT A. , LAATSCH H. , RAK G.
Published: May 2016

The mycelia of Amblyosporium spongiosum contain orange unstable antibiotics.
ChemInform Abstract: Epoxidation of Unsaturated Macrolides: Stereocontrolled Routes to Ionophore Subunits.
Authors: SCHREIBER S. L. , SAMMAKIA T. , HULIN B. , SCHULTE G.
Published: May 2016

The racemic cyclohexanone (I) serves as key compound for the synthesis of the cyclic epoxide (IV), while the second cyclic epoxide (VI) is obtained from the peroxide (V).
ChemInform Abstract: Methanol Synthesis on Silica‐Supported Platinum Catalysts: The Effect of Chromium Additive
Authors: NGUYEN H. P. , MERIAUDEAU P. , NACCACHE C.
Published: May 2016

Review: (24 refs.
ChemInform Abstract: Kinetics and Morphology of GaAs Etching in Aqueous CrO3 ‐ HF Solutions.
Authors: VAN DE VEN J. , WEYHER J. L. , VAN DEN MEERAKKER J. E. A. M. , KELLY J. J.
Published: May 2016

On the basis of two ternary composition diagrams, three regions of different etching kinetics can be delineated for the etching of n‐ and p‐type GaAs in the H2O ‐ CrO3 ‐ HF system.
ChemInform Abstract: Organic‐Inorganic Contact Barrier Heights: A Survey of Materials.
Authors: SCHMIDT P. H. , FORREST S. R. , KAPLAN M. L.
Published: May 2016

Organic‐oninorganic contact barrier energies have been determined for several inorganic semiconductor Substrate materials in contact with two different aromatic thin film materials.
ChemInform Abstract: Reduction of Surface Stacking Faults on N‐Type (100)Silicon Wafers.
Authors: KOOB P. W. , FRAUNDORF G. K. , CRAVEN R. A.
Published: May 2016

It is shown that the reason that n‐type (l00)Si wafers usually form stacking faults rather than S‐ pits after a 1100°C steam oxidation in the presence of metal contamination is that their surfaces can more easily be contaminated with metals compared to other wafer types and orientations.
ChemInform Abstract: Hydrogen Absorption in ε‐Ti3P.
Authors: HALTER U. , MROWIETZ M. , WEISS A.
Published: May 2016

From the absorption isotherms in the ranges 935 ä T ä 1175 Kand 0.009 ä p(H2) g 1 bar AH° H = ‐42.2 kJ mol‐1 and a linear dependence of AHH on the hydrogen concentration are found.
ChemInform Abstract: Electrochemical Characterization of Electrodes with Submicrometer Dimensions.
Authors: HEPEL T. , OSTERYOUNG J.
Published: May 2016

An electrode assembly containing over a million active electrodes on 1 cm2 area has been prepared on a silicon substrate using electron beam lithography.
ChemInform Abstract: CoX2(NO)(PMe3)2 Complexes: an Example of the Influence of X (X: Cl, Br, I, NO2) on the Stereochemistry and Electronic Structure of the Five‐coordinate {Co ‐ NO}8 Complexes.
Authors: ALNAJI O. , PERES Y. , DARTIGUENAVE M. , DAHAN F. , DARTIGUENAVE Y.
Published: May 2016

The title complexes exhibit markedly different v(NO) stretching frequencies and different geometries.
ChemInform Abstract: Chirospecific Synthesis of (S)‐(+)‐ and (R)‐(‐)‐5‐Amino‐4‐hydroxypentanoic Acid from L‐ and D‐Glutamic Acid via (S)‐(+)‐ and (R)‐(‐)‐5‐Hydroxy‐2‐oxopiperidine.
Authors: HERDEIS C.
Published: May 2016

(S)‐5‐Hydroxy‐2‐oxopiperidin (VI) wird stereospezifisch in "5 Stufen aus L‐Glutaminsäure (I) hergestellt und anschließend mit Bariumhydroxid zur Amino‐hydroxycarbonsäure (VII) gespalten.
ChemInform Abstract: Lewis Acid Promoted Aromatic Cyclization of α‐Chlorosulfides: Synthesis of Ethyl Isothiochroman‐1‐carboxylate and Related Compounds.
Authors: ISHIBASHI H. , OKADA M. , IIDA K. , IKEDA M.
Published: May 2016

Aus den Ethoxycarbonylmethyl‐sul?den (I) entstehen über die Chlorverbindungen (II) die Cyclisierungsprodukte (III), die zu Carbonsäuren (IV) verseift werden können.
ChemInform Abstract: Ring Transformation of 3‐Hydroxy‐l,2,5‐ and ‐1,2,4‐thiadiazoles and ‐isothiazoles into Isothiazole, Thiazole and Thiophene Derivatives.
Authors: MATAKA S. , TAKAHASHI K. , TASHIRO M.
Published: May 2016

Die Hydroxythiazole (I), (VI) und (X) reagieren in Acetanhydrid in Gegenwart von DBU je nach Reaktionstemperatur unter Ringtransformation zu den um ein Stickstoffatom im Ring ärmeren Folgeprodukten (II)‐(V), (VII), (VIII), (XI)‐(XIII) sowie (XV) und (XVI) neben den Acetylierungsprodukten (IX) und (XIV).
ChemInform Abstract: Organotellurinic Acid Anhydrides as Selective Oxidants in Organic Synthesis.
Authors: BARTON D. H. R. , FINET J.‐P. , THOMAS M.
Published: May 2016

The aryl tellurinic anhydrides (II), which are prepared from the trichlorides (I), are shown to be useful selective oxidants.
ChemInform Abstract: Iodotrimethylsilane Reduction of Benzoins: Synthesis of Deoxybenzoins and Tetraarylfurans.
Authors: KREPSKI L. R. , HEILMANN S. M. , RASMUSSEN J. K. , TUMEY M. L. , SMITH H. K. II
Published: May 2016

Bei der Reduktion der Benzoine (I) mit Trimethylsilyliodid (II) entstehen Gemische aus den Desoxybenzoinen (III) und den Furanen (IV).
ChemInform Abstract: Halogenation by Phase Transfer Catalysis.
Authors: REEVES W. P. , CRESWELL M. W. , GLASS D. S. , SCHEIDE G. M.
Published: May 2016

The ketones (I), (V) and (IX) and some of its derivatives have been halogenated with CCL, under phase transfer catalytic conditions.
ChemInform Abstract: ′The Synthesis of 10,10‐Disubstituted Anthrones via the Rearrangements of 9‐Anthryl Ethers.
Authors: BRANZ S. E. , CARR J. A.
Published: May 2016

Bei der Alkylierung des aus (Ia) über (Ib) hergestellten Phenylanthrons (Ic) werden Gemische der O‐Alkylierungsprodukte (III) und der C‐Alkylierungsprodukte (IV) erhalten.
ChemInform Abstract: Synthesis of Diisopropylidenethiirane (Thiiranoradialene) and Its Reactions.
Authors: ANDO W. , HANYU Y. , KUMAMOTO Y. , TAKATA T.
Published: May 2016

The title compound (VII) is prepared by a sequence of two ring contractions involving the carbene reaction of (III) t‐o give (IV) and the transformation of the carbene (VI) to give (VII).
ChemInform Abstract: Stereochemistry and Ring Opening of a Carbocyclic Analogue of a 1‐Oxapenam.
Authors: AGATHOCLEOUS D. , COX G. , PAGE M. I.
Published: May 2016

Das aus dem Säurechlorid (I) erhaltene Keten (II) reagiert mit 2,3‐Dihydrofuran (III) zum Addukt (IV), das mit Boranat zum Carbinol (V) reduziert bzw. salzsauer zum Keton (VI) gespalten wird.
ChemInform Abstract: The Asymmetric Transformation of a 1,2‐Dihydro‐3H‐pyrrolo[1,2‐a]pyrrole‐1‐carboxylate Ester.
Authors: HAGMANN W. K.
Published: May 2016

Aus der racemischen Säure (Ia) entsteht mit dem optisch aktiven (R)‐Alkohol (II) ein Gemisch der diastereomeren Ester d‐(Ib) und l‐(Ib), das beim Umkristallisieren in Gegenwart katalytischer Mengen DBN (III) in überwiegendem Maße zu l‐(Ib) isomerisiert wird.
ChemInform Abstract: Preparation of Pyrrolo[3,2,1‐jk]carbazole by Nickel(0) Mediated Ring Contraction of Pyrrolo[3,2,1‐jk]phenothiazine.
Authors: KLINGSTEDT T. , HALLBERG A. , DUNBAR P. , MARTIN A.
Published: May 2016

Die substituierten Acetaldehyde (I) werden an Molekularsieben zu den Tetracyclen (II) kondensiert.
ChemInform Abstract: On the Synthesis of Geometric Isomers of 2‐Methyl (or Phenyl)‐4‐[α‐ arylethylidene]‐5(4H)‐oxazolones.
Authors: CATIVIELA C. , DIAZ DE VILLEGAS M. D. , MELENDEZ E.
Published: May 2016

Die Carbonylverbindungen (I) und die Acylglycine (II) werden zu den Arylidenoxazolonen (III) kondensiert.
ChemInform Abstract: Phase‐Transfer Catalysis of Dipolar Species. 1,3‐Dipolar Cycloadditions of Pyridinium Ylides in a Liquid‐Liquid Biphasic System.
Authors: GANDASEGUI M. T. , ALVAREZ‐BUILLA J.
Published: May 2016

The title reaction between the ylides (I) and the dipolarophiles (II) furnishes the cycloadducts (III) in various yields.
ChemInform Abstract: Synthesis and Stereochemistry of Fluorene‐9 and Benzo[b]fluorene‐11‐spiro‐ 5′‐[1′,3′]dioxanes.
Authors: HAHN W. E. , SOKOLOWSKA A.
Published: May 2016

The preparation of the fluorene‐9‐dioxanes (III) and of the benzofluorene‐l l‐dioxanes (V) is described.
ChemInform Abstract: (Perhalogenomethylthio)heterocycles. Part 19. Production and Properties of Tetrakis(trifluoromethylthio)thiophene, Tetrakistrifluoromethyl‐ thio)‐1,2‐dithiine, 2,3,4‐Tris(trifluoromethylthio)‐5‐trifluoromethyl‐ thiophene and 1‐Chloro‐tetrakis(trifluoromethylthio)pyrrole.
Authors: HAAS A. , KLARE C. , KRAECHTER H.‐U. +
Published: May 2016

Das bereits früher beschriebene Tetrakis‐(trifluormethylthio)‐pyrrol (II) wird in die N‐Chlorverbindung (I) sowie über das Silbersalz mit Trifluormethylsulfenylchlorid (III) in Pentakis‐(tri?uormethylthio)‐ pyrrol (IV) übergeführt.
ChemInform Abstract: Synthesis of 4‐(2H‐1,2,3‐Triazol‐2‐yl)pyrimidines.
Authors: GIAMMANCO L. , INVIDIATA F. P.
Published: May 2016

Die Triazolylpyrimidine (III) werden entweder direkt durch Umsetzung der Hydrazine (I) mit den α‐Dicarbonyloximen (II) oder über die Kondensationsprodukte (V) erhalten.
ChemInform Abstract: A Convenient Synthesis of Novel [1,2,4]Triazolo[4,3‐a][1,5]benzodiazepine Derivatives.
Authors: AVERSA M. C. , FERLAZZO A. , GIANNETTO P. , KOHNKE F. H.
Published: May 2016

Durch Cycloaddition der Imidchlorid‐Derivate (II) an die Benzodiazepine (I) bzw. (IV) entstehen die tricyclischen (III) bzw. tetracyclischen Addukte (V).
ChemInform Abstract: Synthesis via Sigmatropic Rearrangements. Part 11. [3,3]‐Sigmatropic Rearrangement of Silyl Ketene Acetals of Methyl α‐(Allyloxy)acetates.
Authors: RAUCHER S. , GUSTAVSON L. M.
Published: May 2016

Aus den Estern (I), (III), (V) und (VII) werden die Umlagerungsprodukte (II), (IV), (VI) und (VIII) erhalten.
ChemInform Abstract: The Catalysis of Tetraalkyldiphosphone Imide Decomposition.
Authors: FOSS V. L. , NEGANOVA E. G. , VEITS YU. A. , TOROCHESHNIKOV V. N.
Published: May 2016

Die Zersetzung des Diphosphanimids (I) zu dem Diphosphan (III) verläuft in Konkurrenz zur Umlagerung zum Bis‐phosphanoamin (II).
ChemInform Abstract: Relative Reactivity of 2‐Diphenylphosphinoyl‐ and 2‐Diphenylthiophosphinoyl‐ 2‐[1,3]dithianyllithium as Wittig‐Horner/Corey‐Seebach Reagents.
Authors: JUARISTI E. , GORDILLO B. , VALLE L.
Published: May 2016

The reaction of (I) with BuLi and (II) gives a phosphine intermediate, which is converted to (IIIa) and (IIIb) by spontaneous oxidation during work‐up or treatment with elemental sulfur, respectively.
ChemInform Abstract: Synthesis, Characterization, and Crystal Structure of a Hexaaza Macrocyclic Complex of Lutetium(III).
Authors: BOMBIERI G. , BENETOLLO F. , POLO A. , DE COLA L. , SMAILES D. L. , VALLARINO L. M.
Published: May 2016

The Schiff‐base condensation of 2,6‐diacetylpyridine and 1,2‐diaminoethane ,in the presence of Lu(III) acetate (MeOH, reflux, 6 h), followed by precipitation with perchlorate ions yielded the title complex (I), which crystallizes in the space group P1 with Z=2.
ChemInform Abstract: Tungsten ‐ Tungsten Triple Bond. Part 12. Bis(1,3‐diaryltriazenido)bis(dimethylamido)diethylditungsten (M ≡ M) Compounds.
Authors: CHISHOLM M. H. , CHIU H. T. , HUFFMAN J. C. , WANG R. J.
Published: May 2016

anti‐ and gauche‐isomers of the W2 complex (I) react with 1,3‐diaryltriazenes to give the disubstitution products (II) in three isomeric forms A, B, and C. Isomers Aand Bare formed kinetically from gauche‐ and anti‐(I), respectively.
ChemInform Abstract: Synthesis, Characterization, and Structure of a Novel Hexanuclear Iron‐Sulfur‐Carbonyl Cluster, the [Fe6S6(CO)12]2‐ Ion.
Authors: LILLEY G. L. , SINN E. , AVERILL B. A.
Published: May 2016

The title complex is prepared by reaction of a solution of Fe2(SH)2(CO)6 in THF with a solution of [NEt4]2[Fe2S2Cl4] in the presence of NEt3 in DMF at 0°C or via partial oxidative decarbonylation of Fe2S2(CO)6 by addition to a "o‐xylylene‐a,on′‐dithiolate‐disulfide" mixture arising from the reaction of 1,2‐bis(mercaptomethyl)benzol with BuLi followed by oxidation of half the thiolates with I2 in THF (yield 29%).
ChemInform Abstract: N‐Acyl isocyanide Complexes of Iron(II) Porphyrins: Analogy Between the Bonding Properties of N‐Acyl Isocyanides and Carbon Monoxide.
Authors: LE PLOUZENNEC M. , BONDON A. , SODANO P. , SIMONNEAUX G.
Published: May 2016

N‐Acyl isocyanide Complexes of Iron(II) Porphyrins: Analogy Between the Bonding Properties of N‐Acyl Isocyanides and Carbon Monoxide.
ChemInform Abstract: Nature of the Axial Bond Between Dimethyl Sulfoxide and a Series of Dirhodium Complexes.
Authors: CHAVAN M. Y. , LIN X. Q. , AHSAN M. Q. , BERNAL I. , BEAR J. L. , KADISH K. M.
Published: May 2016

The dirhodium complexes (I) are synthesized by the stepwise exchange reaction of Rh2(OOCCH3)4 with acetamidate ligands.
ChemInform Abstract: Synthesis and Photo ‐ Redox Behavior of cis‐N,N′‐Bridged Indigos.
Authors: SETSUNE J. , FUJIWARA T. , KITAO T.
Published: May 2016

On irradiation with visible light in benzene solution in the presence of triethylamine, compounds (IIIa), (IIIb) (n : 4) and (IVb) are reduced in two one‐electron steps: initially a semi‐reduced racfilcal is formed as a transient state; further reduction affords the leuko formmecom?anied by increasing absorption at shorter wavelengths.
ChemInform Abstract: Synthesis of 6,7‐Diazacholestane Derivatives.
Authors: MORZYCKI J. W. , SICINSKI R. R.
Published: May 2016

Starting from 7‐dehydrocholesterol acetate (I) the diazasteroid analogues (VI) and (VII) are prepared.
ChemInform Abstract: A Lithiation Route to C‐5 Substitution of an Imidazole Nucleoside and Its Application to the Synthesis of 3‐Deazaguanosine.
Authors: TANAKA H. , HIRAYAMA M. , SUZUKI M. , MIYASAKA T. , MATSUDA A. , UEDA T.
Published: May 2016

Lithiation of the compound (II) affords the C‐5 anion which reacts with a series of electrophiles to provide the 5‐substituted derivatives (III).
ChemInform Abstract: Doping by Secondary Implantation.
Authors: JORKE H. , KIBBEL H.
Published: May 2016

The secondary implantation of Sb into (100) Si molecular beam epitaxy layers is reported.
ChemInform Abstract: ESR and Mößbauer Studies of the Crystallization Process of Iron Phosphate Glass.
Authors: TANAKA K. , SOGA N. , OTA R. , HIRAO K.
Published: May 2016

The results indicate that there exist a distribution of ligand fields around Fe ions in the 0.7 R320, 0.3 P2O5 glass.
ChemInform Abstract: Pretreatments of Porous Silica for Improving the Activity of a Nickel‐Loaded Catalyst.
Authors: ARAI M. , IKUSHIMA Y. , NISHIYAMA Y.
Published: May 2016

Pretreatment of the support with H2O, EtOH, or BuOH improves the activity of Ni/siOz catalysxs for ethane hydrogenolysis and furan hydrogenation as well as their thermal stability.
ChemInform Abstract: Preparation and Coercivity of Cobalt Ultrafine Particles by Reduction of Multilayered CoO ‐ SiO Films.
Authors: BANDO Y. , TERASHIMA T.
Published: May 2016

Films containing ultrafine Co particles are prepared by reduction of CoO ‐ SiO multilayered films in H2.
ChemInform Abstract: Asymmetric Oxidation of Sulfides with Optically Active Hydroperoxides Prepared by Singlet Oxygenation of Thiazolidine Derivatives.
Authors: TAKATA T. , ANDO W.
Published: May 2016

Photosensitized oxidation of the thiazolidine derivatives (I) to give the hydroperoxides (II) followed by addition of the prochiral sulfides (III) gives the chiral sulfoxides (IV) in a single reaction.
ChemInform Abstract: Michael Reactions with α,β‐Unsaturated Amides Activated by the CsF/Si(OCH3)4 System.
Authors: CHUIT C. , CORRIU R. J. P. , PERZ R. , REYE C.
Published: May 2016

When method A) is used in the reactions ofogß‐ethylenic tertiary amides with compounds with activated methylene groups, normal 1,4‐addition products such as (III), (V) or (VIIIa) are observed.
ChemInform Abstract: Reactions of o‐Quinone Monoimides with Sulfoxides, Diazoalkanes and Triphenylphosphine.
Authors: HEINE H. W. , EMPFIELD J. R. , GOLOBISH T. D. , WILLIAMS E. A. , GARBAUSKAS M. F.
Published: May 2016

Die o‐Chinonmonoimide (I) reagieren mit den Sulfoxiden (II) zu den Sulfoximinen (III), das Diimid (IV) und DMSO (V) machen das Sulfoximin (VI) zugänglich.
ChemInform Abstract: Dehydrobromination of γ‐Bromo‐β‐oxonitriles with Silver Oxide in the Presence of 1,3‐Dienes and Ethyl Vinyl Ether.
Authors: FOEHLISCH B. + , HERTER R. , WOLF E.
Published: May 2016

The reaction of the title compounds (I) with the furans and pyrroles (II) and (V) in the presence of AgzO gives the expected [4 + 3] cycloadducts (III), (IV), (VI)‐(IX) and (XI); yields are markedly lower, however, than in the corresponding conversions of unsubstituted furan studied previously.
ChemInform Abstract: Diazafulvenones. Thermal Isomerizations and Eliminations in Alkoxycarbonyl am] Anilinocarbonyl Derivatives of Imidazole.
Authors: MAQUESTIAU A. , TOMMASETTI A. , PEDREGAL‐FREIRE C. , ELGUERO J. , FLAMMANG R. , WIERSUM U. E. , BENDER H. , WENTRUP C.
Published: May 2016

Die Vakuum‐Pyrolyse der Imidazol‐Derivate (I) und (IV) führt zu den Ketenen (II) bzw. (V) als reaktive Zwischenstufen.
ChemInform Abstract: Cerium(IV) Ammonium Nitrate Oxidation of 5‐Hydroxy‐2‐methoxytropone to Bitropolonyl Derivatives and One‐Step Synthesis of 3‐Methoxy‐p‐tropoquinone.
Authors: MORI A. , ISAYAMA Y. , TAKESHITA H.
Published: May 2016

Ce(IV) oxidizes the tropone (Ia) in absolute methanol to give predominantly C ‐Ccoupling products [(11), (V), and (VI), the bis‐monoacetal of the hitherto unknown bisquinone (VII)], whereas no dimeric products are obtainable from (Ib) by Ce(IV) or TKNOJ), oxidation.
ChemInform Abstract: Stoichiometry and Structural Effects in Alcohol Chemisorption/Temperature‐Programmed Desorption on MoO3.
Authors: FARNETH W. E. , STALEY R. H. , SLEIGHT A. W.
Published: May 2016

The mechanism of alcohol oxidation over M093 is examined by using temp.‐programmed desorption spectroscopy with simultaneous microbalance and mass spectral deteclion.
ChemInform Abstract: Facile Reduction of Pyridines with Nickel‐Aluminium Alloy.
Authors: LUNN G. , SANSONE E. B.
Published: May 2016

Nickel‐Aluminium‐Legierung in verdünntem Alkali reduziert Pyridin‐Derivate (I) zu den entsprechenden Piperidinen.
ChemInform Abstract: [Methoxy(phenylthio)methyl]lithium und [Methoxy(phenylthio)(trimethylsily)methyl]lithium. Convenient Reagents for the Facile Conversion of Aldehydes, Ketones and 3‐Alkoxy Enones into Ketene O,S‐Acetal Derivatives.
Authors: HACKETT S. , LIVINGHOUSE T.
Published: May 2016

Das aus Thiophenol (I) 3 und Dimethoxymethan (II) erhaltene Methoxymethylsul?d (III) addiert sich nach Metallierung zum a‐Lithiothioether (IV) an die Ethoxycyclohexenone (V) zu den QS‐Acetalen (VI), die nach Alkylierung zu den Keten‐QS‐acetalen (VIII) zu den Ketoestern (IX) hydrolysiert werden können; die Hydrolyse von (VI) macht die un.
ChemInform Abstract: Palladium‐Catalyzed Double Carbonylation of Aryl Halides Affording α‐Kelo Amides.
Authors: OZAWA F. , YANAGIHARA H. , YAMAMOTO A.
Published: May 2016

In Abhängigkeit von den Reaktionsbedingungen entstehen bei der Palladium‐katalysierten Carbonylierung der o‐Halogenacetanilide (I) mit wechselnden Ausbeuten das doppelte Carbonylierungsprodukt (II) und das Amid (III).
ChemInform Abstract: Practical Synthesis of 1,3‐Dienes Using Allyltriphenylsilane and Titanium Tetraisopropoxide.
Authors: IKEDA Y. , YAMAMOTO H.
Published: May 2016

The triphenylsilyl group as a control element in the Peterson olefination and the alkoxytitanium moiety of the intermediate saIt (II) provide the regioand stereoselective course of the reaction with the aldehydes (III).
ChemInform Abstract: Derivatives of Functionalized Fluoro Esters und Fluoro Ketones.
Authors: KRESPAN C. G.
Published: May 2016

Die funktionalisierten Fluorcarbonsäureester (I) bilden mit tertiären Aminen die quartären Ammoniumcarboxylate (II), deren Pyrolyse im Fan, von (IIb) und (IIc) in Gegenwart von Iod unter Decarboxylierung zu den Iodidcn (III) führt.
ChemInform Abstract: Fluorocarbanion Chemistry. A Versatile Synthesis of Functionalized Fluoro Ketones.
Authors: KRESPAN C. G. , SMART B. E.
Published: May 2016

Durch Addition eines Anions B′ an Fluorolefine (I) zunächst entstehende Fluorcarbanionen werden mit Fluorcarbonsäureestem (II) unter Bildung funktionalisierter Fluorketone (III) abgefangen; bei geänderter Aufarbeitungsmethode werden die entsprechenden Acetale (IV) erhalten.
ChemInform Abstract: Thermally Initiated Reactions of (Z)‐Epoxyhexenynes. A Facile Preparation of 3,4‐Annulated Furans.
Authors: EBERBACH W. , ROSER J.
Published: May 2016

Conversion of the alcohols (I) to the isopropyl ethers ( 1) followed by regioselective alkynylation and a hydroIysis‐dehydration process yields the aldehydes (V).
ChemInform Abstract: Reinvestigaton on the Adducts Derived from N‐Alkyloxaziridine and Phenyl Isothiocyanate.
Authors: KOMATSU M. , OHSHIRO Y. , AGAWA T. , KURIYAMA M. , YASUOKA N. , KASAI N.
Published: May 2016

Aufgrund von Kristallstrukturdaten und 13C‐NMR‐spektroskopische" P Untersuchungen werden den durch Umsetzung von (I) mit (II) entstehenden Cy‐ cloaddukten entgegen früheren Angaben die revidierten Strukturen (III) bis (v) 2W geordnet.
ChemInform Abstract: Brominated Derivatives of 4‐Hydroxy‐ and 4‐Methoxy‐6‐methyl‐2H‐pyran‐2‐ones.
Authors: DE MARCH P. , MORENO‐MANAS M. , PI R. , RIPOLL I. , SANCHEZ‐FERRANDO F.
Published: May 2016

Unter Anwendung bekannter Methoden wird aus den Pyronen (I) eine Vie zah z.Tl. neuer Bromderivate (II) hergestellt.
ChemInform Abstract: Linear Furano Compounds: Synthesis of 7H‐Furo[3,2‐g][1]benzopyran‐7‐ones.
Authors: GEETANJALI Y. , RAJITHA B. , RAO M. K.
Published: May 2016

The benzofurans (I) react with the phenylacetate (III) to give the furobenzopyranones(IIa) and (IIb).
ChemInform Abstract: Formation of Sulfonium Tetrafluoroborates from Reactions of γ,δ‐Unsaturated Ketones with Thiols in the Presence of Boron Trifluoride Etherate.
Authors: MARCHAND A. P. , KAYA R. , MUCHMORE S. W. , VAN DER HELM D.
Published: May 2016

Das Pentacycloenon (I) liefert mit Methylmercaptan (II) und BFyEiherat (III) das Methylthiosulfoniumsalz (IV), das sich mit KOH zum Dithioacetal (V) spalten läßt; HgClz wandelt (V) wieder in (I) um.
ChemInform Abstract: Reaction of Cycloaliphatic Carbodiimides with Oxalyl Chloride.
Authors: RICHTER R. , BARSA E. A.
Published: May 2016

In Abhängigkeit von der Ringgröße der cyclischen Carbodiimide (I) entstehen durch Umsetzung mit Oxalylehlorid bzw. Methoxalylchlorid entweder die tricyclischen Addukte (II) bzw. (V) oder aus dem höhergliedrigen cyclischen Carbodiimid (Ic) die bicyclische Verbindung (III).
ChemInform Abstract: Complexation of Arenes by Macrocyclic Hosts in Aqueous and Organic Solutions.
Authors: DIEDERICH F. , DICK K. , GRIEBEL D.
Published: May 2016

Hydrolysis of the diester (Ia) to give the corresponding dicarboxylic acid followed by reaction with N‐hydroxysuccinimide (III) gives (Ib), which is convcrted to the triamine (Id) via the triamide (Ic).
ChemInform Abstract: Hydroboration. Part 75. Directive Effects in the Hydroboration of Vinyl and Propenyl Heterocycles with Representative Hydroborating Agents.
Authors: BROWN H. C. , PRASAD J. V. N. V. , ZEE S.‐H.
Published: May 2016

Die Regioselektivität der Hydroborierung der Vinyl‐ und PropenyI‐Heterocyclen (I)‐(V) wird mit einer Reihe von Hydroborierungs‐Reagentien (Boran‐Dimethylsul?d, Borabicyclononan, Dicyclohexylboran, Disiamylboran) systematisch untersucht.
ChemInform Abstract: Addition Compounds of Alkali Metal Hydrides. Part 28. Preparation of Potassium Dialkoxymonoalkylborohydrides from Cyclic Boronic Esters. A New Class of Reducing Agents.
Authors: BROWN H. C. , PARK W. S. , CHA J. S. , CHO B. T. , BROWN C. A.
Published: May 2016

Die nach verschiedenen, z.Tl. literaturbekannten Verfahren dargestellten, cyclischen Boronsäureester (I) reagieren mit überschüssigem Kaliumhydrid unter Bildung der entsprechenden Borhydride (ll).
ChemInform Abstract: Triphenylsilyl Cation.
Authors: LAMBERT J. B. , MCCONNELL J. A. , SCHULZ W. J. JUN.
Published: May 2016

The triphenylsilyl cation Ph,Si may be prepared by the Corey method [hydride transfer from the silane (I) to the trityl cation (ll)] as the ion pair in dichloromethane or 1,2‐dichloroethane and as the free ion in acetonitrile or sulfolane.
ChemInform Abstract: Complexes of Thallium(I) and ‐(III) Containing 1,4,7‐Triazacyclononane (L) Ligands. Kinetics and Mechanism of the Reduction of [L2Tl(III)]3+ . Crystal Structure of(N′,N′,N"‐Trimethyl‐1,4,7‐triazacyclononane)thallium(l) Hexafluorophosphate.
Authors: WIEGHARDT K. , KLEINE‐BOYMANN M. , NUBER B. , WEISS J.
Published: May 2016

The 1:1 molar reactions of the macrocyclic triamines with TICI, ‐4H2O in refluxing Chloroform or with TI(NO3)3 and added NaBr or Nal in aqueous solution Iead to the 1:1 complexes (I) with proposed fac‐structure.
ChemInform Abstract: The Metallaoxirane‐Type Structure of Cp2ZrCl(CPh2OCH3) and the Question of Modeling the Chemistry of Alkylidene Units on a Metal Oxide Surface.
Authors: ERKER G. , DORF U. , ATWOOD J. L. , HUNTER W. E.
Published: May 2016

Molecu‐ Iar and crystal structure of the title complex (I) (space group P2,2,2" Z=4), prepared as described previously, are determined by X‐ray analysis.
ChemInform Abstract: Electrochemical Preparation of Triplatinum Complex with a Linear Structure and Its Transformation to an A‐Frame Structure.
Authors: YAMAMOTO Y. , TAKAHASHI K. , YAMAZAKI H.
Published: May 2016

The potentiostatic electrolysis of (I) gave the dimer (II) and a compound (III), the IR spectrum of which showed only terminal isocyanide ligands.
ChemInform Abstract: Cycloaddition Reactions Relevant to the Mechanism of the Ninhydrin Reaction.
Authors: GRIGG R. , MALONE J. F. , MONGKOLAUSSAVARATANA T. , THIANPATANAGUL S.
Published: May 2016

Ruhemanns Purpur (I) reagiert in seiner protonierten Form (II) mit Maleinsäurederivaten (III) zu Adduklen (IV) und mit Methylpropiolat (V) zur Verbindung (VI).
ChemInform Abstract: Synthetic Photochemistry. Part 34. Synthetic Strategy of 5‐8‐5‐Membered Tricyclic Higher Terpenoids Based on the Condensation of Two Optically Active Iridoids, C10‐Synthons Obtained from Photo‐Cycloadduct of Methyl 2,4‐Dioxopentanoate ‐ Isoprene, and Its Application to a Synthesis of the Basic Carbon Skeleton of Fusicoccane.
Authors: KATO N. , NAKANISHI K. , TAKESHITA H.
Published: May 2016

Optical resolution of the (d,l)‐diol (I) is achieved by treatment with trimethoxymethane (II) and the potassium salt of 1‐menthol (III) to form, via an orthoester, the 1‐menthyliridenoates (IV) and (V).
ChemInform Abstract: A Simple and Efficient Synthesis of Optically Active (+)‐4‐Demethoxydaunomycinone.
Authors: KIMURA Y. , SUZUKI M. , MATSUMOTO T. , ABE R. , TERASHIMA S.
Published: May 2016

Quinizalin (I) is oxidized to give the tetrone (II), which undergoes DieIs‐Alder reaction with chloroprene (III) to afford the tetracyclic tetrone (IV).
ChemInform Abstract: Decarboxylation of α‐Cyanoalkylidene Esters and Acids. Synthesis of Cyclohexyl Constituents of the Pheromone of the Boll Weevil.
Authors: GHOSH A. , BANERJEE U. K. , VENKATESWARAN R. V.
Published: May 2016

De‐ethoxycarbonylation of the ester (II) or decarboxylation of the acid (IV) Ieads to the nitrile (III), which exists as four isomers.
ChemInform Abstract: Retrosynthetic and Synthetic Chemistry on Amphotericin B. Synthesis of C(1) ‐ C(20) and C(21)‐ C(38) Fragments and Construction of the 38‐Membered Macrocycle
Authors: NICOLAOU K. C. , CHAKRABORTY T. K. , DAINES R. A. , SIMPKINS N. S.
Published: May 2016

Amphotericin (I) wird gemäß Formelschema in die Fragmente (1V) und (V) um".
Vismodegib or cixutumumab in combination with standard chemotherapy for patients with extensive‐stage small cell lung cancer: A trial of the ECOG‐ACRIN Cancer Research Group (E1508)
Authors: Belani Chandra P. , Dahlberg Suzanne E. , Rudin Charles M. , Fleisher Martin , Chen Helen X. , Takebe Naoko , Velasco Mario R. , Tester William J. , Sturtz Keren , Hann Christine L. , Shanks James C. , Monga Manish , Ramalingam Suresh S. , Schiller Joan H.
Published: May 2016

BACKGROUND

Preclinical targeting of the hedgehog pathway by vismodegib and of insulin‐like growth factor 1 receptor by cixutumumab enhances the efficacy of chemotherapy and also demonstrates activity against the tumor cell fraction responsible for disease recurrence in small cell lung cancer.

METHODS

Patients with newly diagnosed extensive‐stage small cell lung cancer (SCLC‐ED) were randomized to receive four 21‐day cycles of cisplatin and etoposide alone (cisplatin at 75 mg/m2 on day 1 and etoposide at 100 mg/m2 on days 1‐3; arm A) or in combination with either vismodegib (150 mg/d by mouth; arm B) or cixutumumab (6 mg/kg/wk intravenously on day 1; arm C). The primary endpoint was progression‐free survival (PFS). Circulating tumor cells (CTCs) were isolated/enumerated with the Veridex CellSearch platform at the baseline.

RESULTS

One hundred fifty‐two eligible patients were treated. Patient demographics and disease characteristics were well balanced between the 3 arms except for the higher rate with a performance status of 0 in arm B (P = .03). The median PFS times in arms A, B, and C were 4.4, 4.4, and 4.6 months, respectively; the median overall survival (OS) times were 8.8, 9.8, and 10.1 months, respectively; and the response rates were 48%, 56%, and 50%, respectively. None of the comparisons of these outcomes were statistically significant. The median OS was 10.5 months for those with low CTC counts (≤100/7.5 mL) at baseline and 7.2 months for those with high CTC counts (hazard ratio, 1.74; P = .006).

CONCLUSIONS

There was no significant improvement in PFS or OS with the addition of either vismodegib or cixutumumab to chemotherapy in patients with SCLC‐ED. A low baseline CTC count was associated with a favorable prognosis. Cancer 2016;122:2371–2378. © 2016 American Cancer Society.
Solitary wave solutions of coupled boussinesq equation
Authors: Abazari Reza , Jamshidzadeh Shabnam , Biswas Anjan
Published: May 2016

This article presents the general case‐study of our previous works regarding generalized Boussinesq equations [17, 18, 19], that focus on application of various subordinate methods where are applied to construct more general exact solutions of the coupled Boussinesq equations. In this article, the
‐expansion method is applied on coupled Boussinesq equations. Our work is motivated by the fact that the
‐expansion method provides not only more general forms of solutions but also periodic, solitary waves, and rational solutions. The method appears to be easier and faster by means of a symbolic manipulation program. © 2016 Wiley Periodicals, Inc. Complexity 21: 151–155, 2016
Theoretical stress calculations in polar, semipolar and nonpolar AlGaN/GaN heterostructures of different compositions
Authors: Paszkiewicz Bartlomiej K. , Szymanski Tomasz , Tlaczala Marek
Published: May 2016

The new comprehensive model of the process for matching epitaxial layers to substrates, in dependence of theirs crystallographic orientation, was developed to allow a theoretical prediction of the strain and stress in thin AlGaN epitaxial layers with different composition grown on GaN template. The elements of the continuous anisotropic materials strength theory was applied to develop the model. It was observed that in AlGaN/GaN heterostructures the stress was greater than the upper limit of acceptable tensile stress even for a small Al content and also that the stress could greatly vary, in a value and a direction, depending on substrate crystallographic orientation and an Al content in AlGaN layer. The obtained results theoretically explained the commonly observed technological problems occurring during the growth of AlGaN layers even with a small Al content.
Inversion response to optimize lumped‐element circuits for metamaterial
Authors: Uddin M. Jasim , Ullah M. Habib , Latef T. A. , Mahadi W. N. L.
Published: May 2016

Enhancing electromagnetic research on prior light bend mechanisms is a significant issue for composite material phenomena, and one that is not available in nature. The unit cell of metamaterial can be revised, such that it is significantly smaller than the free space of the wavelength. It is essential to extend the appropriate retrieval process to measure electrical and magnetic responses to the backward wave propagation and dispersion diagram characteristics. In this paper, we propose a retrieval process inversion response between known and unknown parameters of the lumped unit‐cell circuits that optimizes the best fit parameters. By utilizing the optimization of particle swarm techniques, we provide appropriate values of periodic unit cells of CRLH transmission line circuits that matched with the microstrip implementation model. The group velocity of the wave is indicated in the parallel direction, whereas the phase velocity is in the anti‐parallel direction. The dispersion diagram displayed a specifically left‐handed and right‐handed medium, and a tiny band gap appeared in the attenuation medium. The constitutive parameters of dielectric permittivity, permeability, and refractive index were obtained from the periodic composite transmission line circuits.
dHb9 expressing larval motor neurons persist through metamorphosis to innervate adult‐specific muscle targets and function in Drosophila eclosion
Authors: Banerjee Soumya , Toral Marcus , Siefert Matthew , Conway David , Dorr Meredith , Fernandes Joyce
Published: May 2016

The Drosophila larval nervous system is radically restructured during metamorphosis to produce adult specific neural circuits and behaviors. Genesis of new neurons, death of larval neurons and remodeling of those neurons that persistent collectively act to shape the adult nervous system. Here, we examine the fate of a subset of larval motor neurons during this restructuring process. We used a dHb9 reporter, in combination with the FLP/FRT system to individually identify abdominal motor neurons in the larval to adult transition using a combination of relative cell body location, axonal position, and muscle targets. We found that segment specific cell death of some dHb9 expressing motor neurons occurs throughout the metamorphosis period and continues into the post‐eclosion period. Many dHb9 > GFP expressing neurons however persist in the two anterior hemisegments, A1 and A2, which have segment specific muscles required for eclosion while a smaller proportion also persist in A2–A5. Consistent with a functional requirement for these neurons, ablating them during the pupal period produces defects in adult eclosion. In adults, subsequent to the execution of eclosion behaviors, the NMJs of some of these neurons were found to be dismantled and their muscle targets degenerate. Our studies demonstrate a critical continuity of some larval motor neurons into adults and reveal that multiple aspects of motor neuron remodeling and plasticity that are essential for adult motor behaviors. © 2016 Wiley Periodicals, Inc. Develop Neurobiol 76: 1387–1416, 2016
A phylogenetic analysis of macroevolutionary patterns in fermentative yeasts
Authors: Paleo‐López Rocío , Quintero‐Galvis Julian F. , Solano‐Iguaran Jaiber J. , Sanchez‐Salazar Angela M. , Gaitan‐Espitia Juan D. , Nespolo Roberto F.
Published: May 2016

When novel sources of ecological opportunity are available, physiological innovations can trigger adaptive radiations. This could be the case of yeasts (Saccharomycotina), in which an evolutionary novelty is represented by the capacity to exploit simple sugars from fruits (fermentation). During adaptive radiations, diversification and morphological evolution are predicted to slow‐down after early bursts of diversification. Here, we performed the first comparative phylogenetic analysis in yeasts, testing the “early burst” prediction on species diversification and also on traits of putative ecological relevance (cell‐size and fermentation versatility). We found that speciation rates are constant during the time‐range we considered (ca., 150 millions of years). Phylogenetic signal of both traits was significant (but lower for cell‐size), suggesting that lineages resemble each other in trait‐values. Disparity analysis suggested accelerated evolution (diversification in trait values above Brownian Motion expectations) in cell‐size. We also found a significant phylogenetic regression between cell‐size and fermentation versatility (R2 = 0.10), which suggests correlated evolution between both traits. Overall, our results do not support the early burst prediction both in species and traits, but suggest a number of interesting evolutionary patterns, that warrant further exploration. For instance, we show that the Whole Genomic Duplication that affected a whole clade of yeasts, does not seems to have a statistically detectable phenotypic effect at our level of analysis. In this regard, further studies of fermentation under common‐garden conditions combined with comparative analyses are warranted.