bluuebunny/crossref_metadata_2025 huggingface dataset:
A Comparison of Explainable Artificial Intelligence Methods in the Phase Classification of Multi-Principal Element Alloys
Authors: Lee Kyungtae , Ayyasamy Mukil V. , Ji Yangfeng , Balachandran Prasanna V.
Published: February 2022

We demonstrate the capabilities of two model-agnostic local post hoc model interpretability methods, namely breakDown (BD) and shapley (SHAP), to explain the predictions of a black-box classification learning model that establishes a quantitative relationship between chemical composition and multi-principal element alloys phase formation. We trained an ensemble of support vector machines using a dataset with 1,821 instances, 12 features with low pair-wise correlation, and seven phase labels. Feature contributions to the model prediction are computed by BD and SHAP for each composition. The resulting BD and SHAP transformed data are then used as inputs to identify similar composition groups using k-means clustering. Explanation-of-clusters by features reveal that the results from SHAP agree more closely with the literature. Visualization of compositions within a cluster using Ceteris-Paribus (CP) profile plots show the functional dependencies between the feature values and predicted response. Despite the differences between BD and SHAP in variable attribution, only minor changes were observed in the CP profile plots. Explanation-of-clusters by examples show that the clusters that share a common phase label contain similar compositions, which clarifies the similar-looking CP profile trends. In the limits of a dataset with independent and non-interacting features, SHAP and BD appear to capture similar pattern.
Genome-wide Analysis of R2R3-MYB Transcription Factors in Boehmeria nivea (L.) Gaudich Revealed Potential Cadmium Tolerance and Anthocyanin Biosynthesis Genes
Authors: Feng Xinkang , Abubakar Aminu Shehu , Chen Kunmei , Yu Chunming , Zhu Aiguo , Chen Jikang , Gao Gang , Wang Xiaofei , Mou Pan , Chen Ping
Published: February 2022

MYB transcription factor (TFs) are one of the largest families in plants, and involved in many biological processes, including growth and development, metabolism and stress response. The MYB TFs has been extensively studied in various plant species. However, comprehensive information on MYB TFs in fiber crop ramie are still unknown. In the current study, a total of 105 BnGR2R3-MYB genes were identified from ramie genome and subsequently grouped into 35 subfamilies according to phylogeny divergence and sequences similarity. Chromosomal localization, gene structure, synteny analysis, gene duplication, promoter analysis, molecular characteristics and subcellular localization were accomplished using several bioinformatics tools. Collinearity analysis showed that the segmental and tandem duplication events is the dominant form of the gene family expansion, and duplications prominent in distal telomeric regions. Highest syntenic relationship was obtained between BnGR2R3-MYB genes and that of Apocynum venetum (88). Furthermore, transcriptomic data and phylogenetic analysis revealed that BnGMYB60, BnGMYB79/80 and BnGMYB70 might inhibit the biosynthesis of anthocyanins, and UPLC-QTOF-MS data further supported the results. The quantitative real-time qRT-PCR and phylogenetic analysis indicated that the six genes (BnGMYB9, BnGMYB10, BnGMYB12, BnGMYB28, BnGMYB41, BnGMYB78) were cadmium stress responsive genes. Especially, the expression of BnGMYB10/12/41 in roots, stems and leaves all increased more than 10-fold after cadmium stress, and in addition they may interact with key genes regulating flavonoid biosynthesis. Thus, a potential link between cadmium stress response and flavonoid synthesis was identified through protein interaction network analysis. In conclusion, the studies increase our understanding of the functional roles of MYBs and provided valuable foundation for study of structural and regulatory genes in ramie.
Assessing geodynamic activity of rock by the borehole survey results
Authors:   Bulashevich Institute of Geophysics UB RAS, Bazhenova Evgeniia
Published: February 2022

Research objective is to assess the modern geodynamic environment of the geological environment through borehole measurements of signals of geoacoustic emission and electromagnetic radiation. Research relevance is due to the need to identify geodynamically active zones and areas of increased rock fracturing in wells. Methods of research. Rock geodynamic activity was studied in a well of the North-Taratashsky area of a magnetite quartzite deposit in the Chelyabinsk region. MESh-42 hardware and software complex designed for synchronous registration of geoacoustic emission and electromagnetic radiation signals was used to solve this problem. Geoacoustic emission (GAE) and electromagnetic radiation (EMR) signals were recorded using the shuttle logging technique, which makes it possible to identify zones of rock geodynamic activity along well sections and track the dynamics of these sections in time. Results. The results of the method of geoacoustic emission and electromagnetic radiation signals shuttle logging in well no. 7 of the North-Taratashsky area are shown. Conclusions. In the course of geoacoustic emission and electromagnetic radiation signals studies in well no. 7 of the Severo-Taratashsky area according to the shuttle logging method, zones of increased stress in the geological environment and areas of increased fracture formation were identified, which, in turn, made it possible to subdivide the studied interval according to the geodynamic activity of rocks
Determination of geomechanical properties of the Jurassic and Pre-Jurassic sediments of the Tomsk region
Authors:   National Research Tomsk Polytechnic, Shadrin Andrei S , Konoshonkin Dmitrii ,   Gasprom Neft – Technology Partnerships, Antonov Anton ,   National Research Tomsk Polytechnic, Rukavishnikov Valerii ,   National Research Tomsk Polytechnic, Petrova2 Daria ,   Gasprom Neft – Technology Partnerships
Published: February 2022

Introduction. Geomechanical properties of rocks are used as input data for geomechanical modeling and subsequent calculations of hydraulic fracturing design, assessment of sand production of wells, calculation of drilling stability, assessment of fracturing, and other exploration and development of oil and gas fields related to geomechanics. The quality of the calculations performed significantly depends on the accuracy of determining the geomechanical properties of rocks. However, their accurate determination requires a large volume of core studies, which are often absent. This paper summarizes the correlation between geophysical parameters and geomechanical properties for a series of fields in the Tomsk region, located in the southern part of the Nyurolskaya depression. The above correlations can be used in other fields with similar geological conditions, where the research volume is low or laboratory research is absent. Research objective. Generalization of correlations in the form of diagrams between geophysical parameters and geomechanical properties (Young’s modulus, Poisson’s ratio, ultimate strength, and tangent of the angle of internal friction) for a series of fields in the Tomsk region located in the southern part of the Nyurolskaya depression. Methods of research. The proposed schemes are based on laboratory studies of core samples of various lithotypes, as well as statistical analysis of the data obtained. Research results. The result of the work is the scheme for calculating the mechanical properties. According to the proposed schemes, first, the lithology of the described rocks is considered; then, based on the available set of geophysical studies, a correlation dependence with the specified uncertainty interval is selected. Conclusion. The results of the work conducted make it possible to carry out geomechanical modeling in the shortage or absence of laboratory core studies for the field studied. It is recommended to clarify the proposed correlations when conducting laboratory studies for the object under study.
The technology of mining tungsten-molybdenum ore of Slepaya Zalezh at Tyrnyauz deposit
Authors:   North Caucasian Institute of Mining and Metallurgy (State Technological University), Gabaraev Oleg , Dedegkaeva Nina ,   North Caucasian Institute of Mining and Metallurgy (State Technological University), Gabaraev Georgii ,   North Caucasian Institute of Mining and Metallurgy (State Technological University)
Published: February 2022

Introduction. The article considers the issues of base ore effective mining at the Tyrnyauz tungsten-molybdenum deposit with different methods for filling man-made voids. The objective is to substantiate the reduction in expenditure on the ore-hosting rock mass state control by using tailings to prepare the backfill blends Methods of research. The complex of studies includes the study of engineering and geological conditions of development, the study of the properties of hardening mixture components, the theoretical justification of rock mass stability control methods, and the proposed solutions evaluation. Laboratory studies are carried out on samples made of equivalent and optically active materials. Physical and mechanical properties of rocks and blends are determined using the accepted methods, results are processed by mathematical statistics methods. Results. Ore-hosting rock mass states are analyzed when using a development system with open or filled unbound material. The ore mining technologies type designs by the criterion of rock mass stress control is proposed. The results of modeling the methods of fields development are presented, with and without voids filling, as well as a mathematical model construction and calculation in Maple. The optimal parameters of lost reserves dredging are calculated. The equivalence of qualitative indicators of losses and other field development efficiency indicators has been established. The results of modeling various technologies with different degrees of void filling are given. It is shown that ore loss and dilution mitigation, when optimizing the rock mass state control, compensates for the costs of hardening mixtures. Conclusions and scope of results. Field development without void filling increases losses and dilution to the limit of economic feasibility. There are equivalent ratios between ore quality indicators and other technology indicators, which are the basis for improving the indicators of the lost ore reserves extraction. The obtained results may be in demand when modernizing technologies for the development of solid metal-containing mineral raw materials.
Nanoparticles as Powerful Tools for Crossing the Blood-brain Barrier
Authors: Kazemi-Lomedasht Fatemeh , Hasannejad-Asl Behnam , Pooresmaeil Farkhondeh , Choupani Edris , Dabiri Mehran , Behmardi Abtin , Fadaie Mahmood , Fathi Majid , Moosavi Seyed Akbar , Takamoli Shahla , Hemati Ehsan , Naei Vahid Yaghoubi
Published: February 2022

The blood-brain barrier (BBB) is considered an important protective barrier in the central
nervous system (CNS). The barrier is mainly formed by endothelial cells (ECs) interconnected by various
junctions such as tight junctions (TJs), gap junctions, and adherent junctions. They collectively
constitute an intensive barrier to the transit of different substances into the brain, selectively permitting
small molecules to pass through by passive movement but holding off large ones such as peptides and
proteins to cross the brain. Hence some molecules selectively transfer across the BBB by active routes
via transcytosis. The BBB also forms a barrier against neurotoxins as well as pathogenic agents. Although
various CNS disorders like Alzheimer's disease (AD) and Parkinson's disease (PD) could hamper
the integrity of the border. Nevertheless, the BBB acts as a barrier for CNS disorders treatment because
it prevents the drugs from reaching their target in the CNS. In recent years, different strategies,
including osmotic disruption of BBB or chemical modification of drugs, have been used to transfer the
chemotherapeutic agents into brain substances. Nowadays, nanoparticles (NPs) have been used as an
effective and non-invasive tool for drug delivery and diagnosis of CNS disorders. In this review, we
discuss the structural characteristic of BBB, safe passageways to cross the BBB, and the relation of
barrier lesions with different CNS disorders. In the end, we explore the progress in drug delivery,
diagnosis, imaging, and treatment of CNS disorders using nanoparticles.
Gut Microbiota Modulation for Therapeutic Management of Various Diseases:
A New Perspective Using Stem Cell Therapy
Authors: Ahmed Lamiaa A. , Al-Massri Khaled F.
Published: February 2022

Dysbiosis has been linked to various diseases ranging from cardiovascular, neurologic, gastro-intestinal, respiratory, and metabolic illnesses to cancer. Restoring of gut microbiota balance represents an outstanding clinical target for the management of various multidrug-resistant diseases. Preservation of gut microbial diversity and composition could also improve stem cell therapy which now has diverse clinical applications in the field of regenerative medicine.
Gut microbiota modulation and stem cell therapy may be considered a highly promising field that could add up towards the improvement of different diseases, increasing the outcome and efficacy of each other through mutual interplay or interaction between both therapies. Importantly, more investigations are required to reveal the cross‐talk between microbiota modulation and stem cell therapy to pave the way for the development of new therapies with enhanced therapeutic outcomes.
This review provides an overview of dysbiosis in various diseases and their management. It also dis-cusses microbiota modulation via antibiotics, probiotics, prebiotics, and fecal microbiota transplant to introduce the concept of dysbiosis correction for the management of various diseases. Furthermore, we demonstrate the beneficial interactions between microbiota modulation and stem cell therapy as a way for the development of new therapies in addition to limitations and future challenges regarding the applica-tions of these therapies.
Ethnomedicinal Plants Used for Treatment of Urolithiasis in India: A
Review
Authors: Beldar Vishal Gokul , Sidat Parin Salim , Jadhao Manojkumar M.
Published: February 2022

Background:

Kidney stone is the most commonly observed and painful disease of the
urinary tract in human beings. Numerous intrinsic and extrinsic factors are responsible for the formation
of kidney stones, for instance, age, sex, heredity (intrinsic factors), climate, diet, geography,
mineral composition, and water intake (extrinsic factors). The kidney stones are categorized into
calcium, struvite or magnesium ammonium phosphate, uric acid or urate, cystine, and other types of
stones based on chemical composition and pathogenesis. Due to the multifactorial nature of kidney
stone disease, the patient may need to rely on complex synthetic medication. However, in ancient
Indian history, there are several pieces of evidence where natural resources such as plants were used
to remediation this lethal disease.

Objective:

The present review attempts to provide exhaustive ethnomedicinal and ethnopharmacological
information on medicinal plants used for kidney stones in India.

Result:

Hitherto, 258 ethnomedicinal plants from 90 different families reported using for kidney
stone application. The majority of the plant species are associated with three important families:
Asteraceae, Amaranthaceae, and Fabaceae. Most of the plants are from Andhra Pradesh (43 plants),
followed by East Bengal (38), Jammu & Kashmir (36), Uttarakhand (31), Panjab (27), Mizoram
(23), Karnataka (20), Maharashtra (20) and Assam (18). The commonly used plant parts for the
herbal preparation are roots (21.22 %) followed by leaves/leaf (20.15 %), and sometimes complete
plant (17.77 %) is used. The most commonly used method for the formulation is decoction (46.41
%) followed by powder (18.66 %) and then extracts (15.78 %) of different aerial and non-aerial
parts of the plant. More than sixty ethnomedicinal plants assessed the in-vitro and in-vivo activities
against the kidney stone.

Conclusion:

The present review epitomizes the ethnomedicinal information of medicinal plants
used for kidney stones and pharmacological evidence for anti-urolithiasis activity. Most reported
medicinal plants are not yet scientifically explored and need immediate attention before losing important
species due to excessive deforestation for farming and industrial needs.
Clinical and imaging findings of klippel-trenaunay syndrome
Authors: Dwijaya Anandhika , Atmaja Muhammad Hidayat Surya
Published: February 2022

Klippel-Trenaunay syndrome (KTS) is characterized by the classic triad of capillary malformations manifesting as a "port-wine stain", venous varicosities, and bone and/or soft tissue hypertrophy. Imaging could help to diagnose and evaluation of KTS. Case Presentation: We report a 12-year-old with progressive enlargement of the right lower limb with geographic stain and venous varicosities. The patient also underwent MRI and angiography, which revealed multiple nidus with multiple feeding arteries. Conclusion: Klippel-Trenaunay Syndrome is a rare condtion. MRI and Arteriography could help diagnose KTS for confirmation, monitoring progression, or identification of complications.
Publishing in hijacked Web of Science journals: Analytical and legal study
Authors:   Criminal Law Department, College of Law, American University in the Emirates, Dubai, UAE, Alhawawsheh Ayman Nawwaf Sharif , Al Sawy Yaser Mohamad Mohamad ,   College of Education and Arts, Northern Border University, Arar, Saudi Arabia
Published: February 2022

This study aimed at a legal and scientific analysis of the plagiarized journals within the Web of Science system, in a time when the phenomenon of plagiarism and piracy spread to the titles of scientific and humanities magazines. Researchers sought to analyze the concept of plagiarism of international scientific journals based on its definition in scientific publishing, its dimensions and danger at the academic level of the researcher, and the academic and institutional level of the university. It also analyzed the types of plagiarism that include cloning, copying, substitution, mixing, and repetition as well as the scientific publishing of forged magazines that are no less dangerous and effective than the spoofed magazines. The study obtained several results, the most important of which is the risk for researchers to lose academic promotion and face direct penalties that hinder their path when appropriating funds through unaccredited scientific publications. The study has also reached specific criteria that the researcher must adhere to when seeking publication, the most important of which is the use of accredited websites of scientific journals and international publishers.
Stanje i posebnosti gospodarenja pjeskovitim tlima središnje Podravine
Authors: Bašić Ferdo , Kisić Ivica , Mesić Milan , Turšić Ivan , Zgorelec Željka , Perčin Aleksandra , Šestak Ivana , Bilandžija Darija , Bogunović Igor
Published: February 2022

Ferdo Bašić, Ivica Kisić, Milan Mesić, Ivan Turšić, Željka Zgorelec, Aleksandra Perčin, Ivana Šestak, Darija Bilandžija, Igor Bogunović
The Impact of Long COVID-19 on Mental Health: Observational 6-Month Follow-Up Study
Authors: Houben-Wilke Sarah , Goërtz Yvonne MJ , Delbressine Jeannet M , Vaes Anouk W , Meys Roy , Machado Felipe VC , van Herck Maarten , Burtin Chris , Posthuma Rein , Franssen Frits ME , Vijlbrief Herman , Spies Yvonne , van 't Hul Alex J , Spruit Martijn A , Janssen Daisy JA
Published: February 2022

Background

The psychological impact of COVID-19 can be substantial. However, knowledge about long-term psychological outcomes in patients with COVID-19 is scarce.

Objective

In this longitudinal, observational study, we aimed to reveal symptoms of posttraumatic stress disorder (PTSD) and symptoms of anxiety and depression up to 6 months after the onset of COVID-19–related symptoms in patients with confirmed COVID-19 and persistent complaints. To demonstrate the impact in nonhospitalized patients, we further aimed to compare these outcomes between nonhospitalized and hospitalized patients.

Methods

Demographics, symptoms of PTSD (Trauma Screening Questionnaire [TSQ] ≥6 points) and symptoms of anxiety and depression (Hospital Anxiety and Depression Scale [HADS] ≥8 points) were assessed at 3 and 6 months after the onset of COVID-19–related symptoms in members of online long COVID-19 peer support groups.

Results

Data from 239 patients with confirmed COVID-19 (198/239, 82.8% female; median age: 50 [IQR 39-56] years) were analyzed. At the 3-month follow-up, 37.2% (89/239) of the patients had symptoms of PTSD, 35.6% (85/239) had symptoms of anxiety, and 46.9% (112/239) had symptoms of depression, which remained high at the 6-month follow-up (64/239, 26.8%, P=.001; 83/239, 34.7%, P=.90; 97/239, 40.6%, P=.08, respectively; versus the 3-month follow-up). TSQ scores and HADS anxiety and depression scores were strongly correlated at the 3- and 6-month follow-ups (r=0.63-0.71, P<.001). Symptoms of PTSD, anxiety, and depression were comparable between hospitalized (n=62) and nonhospitalized (n=177) patients.

Conclusions

A substantial percentage of patients with confirmed COVID-19 and persistent complaints reported symptoms of PTSD, anxiety, or depression 3 and 6 months after the onset of COVID-19–related symptoms. The prevalence rates of symptoms of PTSD, anxiety, and depression were comparable between hospitalized and nonhospitalized patients and merely improved over time. Health care professionals need to be aware of these psychological complications and intervene on time in post-COVID-19 patients with persistent complaints.

Trial Registration

Netherlands Trial Register NTR8705; https://www.trialregister.nl/trial/8705.
Teledermatology in German-Speaking Countries: Patients’ and Physicians’ Perspectives
Authors: Greis Christian , Otten Marina , Reinders Patrick
Published: February 2022

Background

With increasing digitalization and the current pandemic, teledermatology has gained importance in German-speaking countries in recent years. The regulation on remote consultation methods was recently relaxed, allowing for a more widespread introduction of teledermatological health care services.

Objective

The aim of this work is to evaluate a store-and-forward (SAF) teledermatology application from the patients’ and physicians’ perspectives.

Methods

We carried out a noncontrolled user survey of the web-based platform derma2go in the course of the remote consultation by German dermatologists. Through the platform, patients with dermatological requests could obtain expert advice within a few hours after entering their medical history and uploading photographs of their skin lesions.

Results

A total of 1476 (t1) and 361 (t2) patients and 2207 dermatologist ratings were included within the evaluation. A large proportion of participants were satisfied with the application (t1=83.9%; t2=81.2%). Most participants also rated the usability as high (t1=83.0% satisfied) and were satisfied with the response time of the dermatologists (t1=92.0% satisfied). In addition, a large majority agreed with the statement that they trusted the web-based application (t1=90.5%). At t2, 20.0% of those who participated stated that their skin problem had healed; for 49.8% of participants, it had already improved; for 22.0% of participants, it was unchanged; and for 3.5% of participants, skin problems had worsened. For 64.0% of users, the request was completely resolved, and for 24.2% or users, it was partly resolved as result of the consultation. For 79.7% of users, no additional information was needed by the participating dermatologists. From the practitioners’ perspective, 71.2% of all requests were completely resolved and 24.7% were partly resolved.

Conclusions

Our evaluation has shown that SAF applications, exemplified by derma2go, are likely to improve access to dermatological care, with a high patient satisfaction and a high rate of resolved requests, from the patients’ and physicians’ perspectives. In the future, teledermatological SAF applications can represent a supplement to the existing routine care in dermatology. The indications, patient groups, and use cases, for which the application is particularly suitable, will be determined in further studies.
Utilization of Palliative Care for Patients with COVID-19 and Acute Kidney Injury during a COVID-19 Surge
Authors: Scherer Jennifer S. , Qian Yingzhi , Rau Megan E. , Soomro Qandeel H. , Sullivan Ryan , Linton Janelle , Zhong Judy , Chodosh Joshua , Charytan David M.
Published: February 2022

Background and objectives

AKI is a common complication of coronavirus disease 2019 (COVID-19) and is associated with high mortality. Palliative care, a specialty that supports patients with serious illness, is valuable for these patients but is historically underutilized in AKI. The objectives of this paper are to describe the use of palliative care in patients with AKI and COVID-19 and their subsequent health care utilization.

Design, setting, participants, & measurements

We conducted a retrospective analysis of New York University Langone Health electronic health data of COVID-19 hospitalizations between March 2, 2020 and August 25, 2020. Regression models were used to examine characteristics associated with receiving a palliative care consult.

Results

Among patients with COVID-19 (n=4276; 40%), those with AKI (n=1310; 31%) were more likely than those without AKI (n=2966; 69%) to receive palliative care (AKI without KRT: adjusted odds ratio, 1.81; 95% confidence interval, 1.40 to 2.33; P<0.001; AKI with KRT: adjusted odds ratio, 2.45; 95% confidence interval, 1.52 to 3.97; P<0.001), even after controlling for markers of critical illness (admission to intensive care units, mechanical ventilation, or modified sequential organ failure assessment score); however, consults came significantly later (10 days from admission versus 5 days; P<0.001). Similarly, 66% of patients initiated on KRT received palliative care versus 37% (P<0.001) of those with AKI not receiving KRT, and timing was also later (12 days from admission versus 9 days; P=0.002). Despite greater use of palliative care, patients with AKI had a significantly longer length of stay, more intensive care unit admissions, and more use of mechanical ventilation. Those with AKI did have a higher frequency of discharges to inpatient hospice (6% versus 3%) and change in code status (34% versus 7%) than those without AKI.

Conclusions

Palliative care was utilized more frequently for patients with AKI and COVID-19 than historically reported in AKI. Despite high mortality, consultation occurred late in the hospital course and was not associated with reduced initiation of life-sustaining interventions.

Podcast

This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2022_02_24_CJN11030821.mp3
Kidney Histopathologic Spectrum and Clinical Indicators Associated with MGRS
Authors: Yong Zi-hao , Yu Xiao-juan , Liu Jing-xia , Zhou Fu-de , Wang Su-xia , Zhao Ming-hui
Published: February 2022

Background and objectives

Patients with monoclonal gammopathy and concomitant kidney diseases are frequently found in clinical practice. Some of them are diagnosed with monoclonal gammopathy of renal significance (MGRS) due to the presence of monoclonal Ig–related kidney injuries. This study aimed to investigate the histopathologic spectrum and clinical characteristics associated with MGRS in a large cohort of patients with monoclonal gammopathy and biopsy-proven kidney diseases from a single Chinese nephrology referral center.

Design, setting, participants, & measurements

Patients who presented with monoclonal gammopathy (monoclonal spike on serum and/or urine immunofixation tests) and underwent kidney biopsy in the Peking University First Hospital from January 1, 1999 to December 31, 2020 were enrolled in this retrospective study. Patients with malignant hematologic diseases were excluded. Clinical and laboratory data were collected from the electronic medical record system. Comparisons of patients with and without MGRS and with and without amyloidosis were performed. The clinical characteristics associated with MGRS were identified using multivariable logistic regression.

Results

A total of 700 patients with monoclonal gammopathy and kidney biopsy were identified. Thirteen patients with repeat kidney biopsies were analyzed separately. For the remaining 687 patients with one kidney biopsy, 261 patients (38%) had MGRS lesions, and the rest (426 patients, 62%) had non-MGRS kidney diseases. Ig-related amyloidosis accounted for the most MGRS cases (n=164, 63%), followed by monoclonal Ig deposition disease (n=23, 9%) and thrombotic microangiopathy (n=22, 8%). In the non-MGRS group, membranous nephropathy was the most common diagnosis (n=171, 40%). In the multivariable logistic regression model, the presence of abnormal serum free light chain ratio, older age, and greater proteinuria were independently associated with MGRS.

Conclusions

Monoclonal Ig amyloidosis is the leading cause of MGRS in Chinese patients with monoclonal gammopathy. The presence of abnormal free light chain ratio, older age, and greater proteinuria were associated with MGRS.
Análisis de las propiedades vibracionales del crotonaldehído: DFT vs MD
Authors: Ruvalcaba Ricardo , Guerrero-Sánchez Jonathan , Takeuchi Noboru
Published: February 2022

La dinámica molecular (MD, por sus siglas en inglés) y la teoría del funcional de la densidad (DFT, por sus siglas en inglés) son actualmente las teorías más utilizadas en ciencia computacional de materiales. Ambas tienen alcances y aplicaciones distintas, pero convergen en ciertas áreas. El presente trabajo hace una comparación y contraste entre la exactitud de ambas teorías para modelar el espectro infrarrojo de una molécula orgánica sencilla pero representativa: el crotonaldehído. Se lleva a cabo un análisis de las energías, distancias de enlace, frecuencias e intensidades vibracionales para determinar las ventajas y desventajas de cada teoría en este marco de cálculo.
Application of Response Surface Methodology (RSM) in optimization of Surface Modification using Friction Stir Processing
Authors: Sharma Shashikant , Gaur M. K.
Published: February 2022

Abstract: Surface modification is the process of enhancing surface properties either through physical, chemical and biological effects in order to achieve superior surface quality. In this dissertation, initially the Aluminium composite is prepared using reinforcement of Boron Carbide nanoparticle which is inserted in a groove prepared on the specimen (AA5083 plate). Furthermore, the specimens are then taken for various tests including Ultimate Tensile Strength, Yield Strength, and characterization of material with the help of XRD and Tribological behavior of material respectively. Results are noted and taken to Analysis of variance for checking the feasibility of the designed model. It is discovered that, p- values for various responses were less than 0.05 which indicates that model is significant while lack of fit is maintained insignificant. Eventually, for obtaining the optimum values for various responses, F value was taken in order to investigate the dominating parameters. Finally conclusion were drawn which reveals that raising the TRS and Number of passes while dropping the TTS promotes better results. Keywords: Friction Stir Process (FSP); Response Surface Methodology; Anova; Hardness; Yield Strength
Direct detection of quantum non-Gaussian light from a dispersively coupled single atom
Authors: Verma Jitendra K. , Lachman Lukáš , Filip Radim
Published: February 2022

Many applications in quantum communication, sensing and computation need provably quantum non-Gaussian light. Recently such light, witnessed by a negative Wigner function, has been estimated using homodyne tomography from a single atom dispersively coupled to a high-finesse cavity. This opens an investigation of quantum non-Gaussian light for many experiments with atoms and solid-state emitters. However, at their early stage, an atom or emitter in a cavity system with different channels to the environment and additional noise are insufficient to produce negative Wigner functions. Moreover, homodyne detection is frequently challenging for such experiments. We analyse these issues and prove that such cavities can be used to emit quantum non-Gaussian light employing single-photon detection in the Hanbury Brown and Twiss configuration and quantum non-Gaussianity criteria suitable for this measurement. We investigate in detail cases of considerable cavity leakage when the negativity of the Wigner function disappears completely. Advantageously, quantum non-Gaussian light can be still conclusively proven for a large set of the cavity parameters at the cost of overall measurement time, even if noise is present.
Argumentation of introducing a discrete-continuous topology in the interests of algorithmization of complex functioning processes
Authors: Malinina Natalia L.
Published: February 2022

The main aim of the research is to show and prove the necessity of introducing a new, discrete-continuous topological structure to describe complicated systems and processes of their functioning. Currently, there are two topological structures: continuous and discrete. At the same time, there are functional approaches in order to describe complicated systems and processes of their functioning, based on continuous topology. Until now, it has not been possible to build full functionality for the design of complicated technical objects. Therefore, the functional approach does not fully correspond to the increasingly complicated tasks of our time. The introduction of discrete-continuous topology is especially important for the exploring and modeling of complicated systems and processes of their functioning. In order to prove this fact, the present study describes the properties of complicated processes using examples of the flight process and the design process. The examination of these processes, as the most complicated, proves that the complicated systems and processes are topological spaces with metric, so they can be represented in the form of an oriented progressively bounded graph. Also, it proves the topological invariants of complicated systems and the processes of functioning. Presentation of the complicated processes in the form of a directed graph allows getting shorter path to their algorithmicization and programming, which is necessary for existing practice. In addition, the presentation of a complicated process as a directed graph will allow using the apparatus of graph theory for such purpose and will significantly expand the capabilities of programmers.
Using gridCoal to assess whether standard population genetic theory holds in the presence of spatio-temporal heterogeneity in population size.
Authors: Trubenova Barbora , Szép Enikő , Csillery Katalin
Published: February 2022

Spatially explicit population genetic models have long been developed,
yet have rarely been used to test hypotheses about the spatial
distribution of genetic diversity or the expected neutral levels of
genetic divergence between populations. Here, we use spatially explicit
coalescence simulations to explore the properties of the island model
and the two-dimensional stepping stone model under a wide range of
scenarios with spatio-temporal variation in deme size. We avoid the
simulation of genetic data, using the fact that under the studied
models, summary statistics of genetic diversity and divergence between
demes can be approximated from coalescence times. We perform the
simulations using gridCoal, a flexible spatial wrapper for the software
msprime developed herein. In gridCoal, deme sizes can change arbitrarily
across space and time, and migration rates between individual demes can
be specified. We identify the different factors that can cause a
deviation from the theoretical expectations, such as the simulation time
in comparison to the effective deme size and the spatio-temporal
autocorrelation across the grid. Our results highlight that Fst, a
measure of the strength of population structure, principally depends on
recent demography, which makes it robust to temporal variation in deme
size. We also warn that predicting genetic diversity from coalescence
times requires a much longer run time than needed for the estimation of
Fst. Finally, we illustrate the use of gridCoal on a real-world example,
the range expansion of silver fir (Abies alba Mill.) since the Last
Glacial Maximum, using different degrees of spatio-temporal variation in
deme size.
'What's Going on Here?' Reflections on Brian Street's Contribution to Literacy Education
Authors: Robinson-Pant Anna
Published: February 2022

As a teacher and researcher of literacy, Brian Street introduced ethnographic inquiry to two quite different communities: adult literacy practitioners in India, Ethiopia and Uganda, and university students in the UK and USA. Through re-visiting his teaching materials and approaches, the article explores how he mediated key concepts within anthropology - such as ‘context’ and an ‘ethnographic frame of mind’ - through practical activities with university students and adult educators. Within higher education, Street’s research on academic literacies both emerged from and built on engagement with students and colleagues around the notion of literacy as a social practice shaped by institutional hierarchies and cultures. In development projects, Street extended his early (1984) research in Iran on multiple literacies, including what he termed UNESCO ‘essay-text’ literacy, into a ‘hands-on’ programme for literacy trainers to investigate everyday literacies often overlooked by formal adult literacy initiatives. Street’s active engagement in literacy teaching and learning resulted in methodological innovation, particularly the development of ‘ethnographic style’ methods. Arguing that applied anthropology was often seen as having a one-directional relationship with education, Street demonstrated that education could also make an intellectual contribution to anthropology in terms of deepening understanding of literacy, language and learning within the discipline.
The Turtle and the Fish in Latin America
Authors: Kalman Judy
Published: February 2022

If you had the opportunity to listen to Brian Street present a talk or read his work, the turtle and the fish will strike a familiar chord. Brian Street was an ethnographer, a literacy researcher, and an overall enthusiast about what human beings did and how they made sense of their worlds. He used the parable of the turtle and the fish to explain how what is familiar to us gets in the way of what is not, and the difficulties and often impossible obstacles to understanding other people’s lives and worlds. In this paper I reflect on Brian and his contribution to understanding literacy as a social practice in Latin America.
Glycemic Control and Clinical Outcomes in U.S. Patients With COVID-19: Data From the National COVID Cohort Collaborative (N3C) Database
Authors: Wong Rachel , Hall Margaret , Vaddavalli Rohith , Anand Adit , Arora Neha , Bramante Carolyn T. , Garcia Victor , Johnson Steven , Saltz Mary , Tronieri Jena S. , Yoo Yun Jae , Buse John B. , Saltz Joel , Miller Joshua , Moffitt Richard
Published: February 2022

Objective: The purpose of the study is to
evaluate the relationship between HbA1c and severity of COVID-19 outcomes in
patients with type 2 diabetes mellitus (T2D) with acute COVID-19
infection.

Research Design and Methods: We
conducted a retrospective study using observational data from the National
COVID Cohort Collaborative (N3C), a longitudinal, multicenter US cohort of
patients with COVID-19 infection. Patients were ≥18 years old with T2D and
confirmed COVID-19 infection by either laboratory testing or diagnosis code.
The primary outcome was 30-day mortality following the date of COVID-19
diagnosis. Secondary outcomes included need for invasive ventilation or ECMO,
hospitalization within 7 days prior to or 30 days after COVID-19 diagnosis, and
length of stay (LOS) for patients who were hospitalized.

Results: The study included 39,616 patients (50.9% female, 55.4% White,
26.4% Black or African American and 16.1% Hispanic or Latino, with mean [SD]
age 62.1 [13.9] years and mean [SD] HbA1c 7.6% [2.0]. There was an increasing
risk of hospitalization with incrementally higher HbA1c levels, but risk of
death plateaued at HbA1c above 8% and risk of invasive ventilation or ECMO
plateaued above 9%. There was no significant difference in LOS across HbA1c
levels.

Conclusions: In a large, multicenter cohort of
patients in the US with T2D and COVID-19 infection, risk of hospitalization
increased with incrementally higher HbA1c levels. Risk of death and invasive
ventilation also increased but plateaued at different levels of glycemic
control.
The under-recognized but essential role of the limbic system in the migraine brain: a narrative review
Authors: Chung Chin-Sang , Schwedt Todd J.
Published: February 2022

Migraine is a very common brain disorder that causes throbbing headaches of moderate-to-severe intensity that are associated with a variety of symptoms like nausea, vomiting, multisensory hypersensitivity, dizziness, fatigue, cognitive dysfunction, and sleep problems, among others. The diverse symptomatology of migraine hints at the complexity of the disease and implies the involvement of multiple nervous system components, including the somatosensory, executive, autonomic, endocrine, and arousal networks. The major pathophysiologic mechanisms responsible for migraine attacks have been identified over the past several decades, and the elucidation of these mechanisms has brought about remarkable advances in therapeutic strategies, including the creation of anti-calcitonin gene-related peptide therapeutics—the newest addition to the list of anti-migraine therapies. However, current knowledge on the pathophysiologic mechanisms of migraine remains incomplete and treatments are only partially effective, with the involvement of the limbic system being less often recognized and symptoms related to the limbic system being undertreated. This article reviews recent advances in understanding the pathophysiologic roles of the limbic system in migraine and how the limbic system contributes to clinical features observed in migraine.
YENİ DİNİ HAREKETLERE GİRİŞTEKİ RİTÜEL VE UYGULAMALAR
Authors: TURAN Süleyman , BAYRAKTAR Zehra
Published: February 2022

Bu çalışmada yeni dini hareketler olarak nitelenen oluşumlara üyelik süreci ve üyelik için gerçekleştirilen ritüeller ve uygulamalar inceleme konusu yapılmaktadır. Mutlak otoriteye sahip bir karizmatik lider ve belirli bir ideoloji etrafında toplanma özellikleriyle ön plana çıkan yeni dini hareketler, geleneksel dini anlayış ve kurumlara meydan okuyarak onların yerini almaya çalışmaktadır. Bu açıdan söz konusu hareketlerin farklı yönleriyle sorgulandıkları ve çeşitli araştırmalara konu edildikleri görülmektedir. Yeni dini hareketlerin sorgulanan ve merak edilen yönlerinden biri de hiç kuşkusuz insanların bu tür oluşumlara katılım süreçlerine ilişkindir. Yeni dini hareketlerin önemli bir bölümü yeni elde ettikleri üyeleri gruba dahil ederken bir takım ritüel, uygulama ve sembollere yer vermektedir. Bazı YDH’ler, vaftiz uygulamasında olduğu gibi, içinden çıktıkları ya da etkilendikleri geleneksel dinin ritüelini aynen ya da belli oranda değişiklerle benimseyip uygularken bazı hareketler, gruba katılımı kendilerine özgü nitelikler taşıyan ayin ya da törenler ile gerçekleştirmektedir. Bazı hareketlerde bu doğrultudaki inanç ve uygulamalara oldukça önem atfedilmesi de dikkat çekicidir.
La apropiación y el reciclaje en la creación audiovisual como recurso crítico. Caso de estudio: La mano que trina. María Cañas
Authors: Gómez Díaz Francisco José
Published: February 2022

La presente investigación muestra el desarrollo de la apropiación y el reciclaje como técnica de creación audiovisual contemporánea, en formato de vídeo y como herramienta crítica, mostrando su evolución y cómo la técnica se enriquece como recurso creativo destacando la evolución de las tecnologías de la información tanto en la creación como en el visionado de las piezas a través de las plataformas digitales actuales. Desde los reproductores VHS, el software de postproducción audiovisual y su implementación, Internet o incluso la manipulación de videojuegos para generar nuevos contenidos. La investigación incluye el análisis de la pieza La mano que trina, de María Cañas, que recoge el espíritu de la técnica apropiacionista y que permite observar cómo la artista documenta y critica, desde el humor, la sociedad de la información contemporánea y su relación con la sociedad de consumo.
The Development of Modeling Physics Learning to Improve Critical Thinking Ability of Student
Authors: Arifuddin Muhammad , Thalib Syamsul Bachri , Jasruddin Jasruddin , Ali Muhammad Sidin
Published: February 2022

The low critical thinking skills of students in fundamental physics courses require an innovative learning model which is the main background in this research. This study aims to (1) know the description of the development of modeling physics learning (2) determine the validity of modeling physics learning to students' critical thinking skills. This type of research is Research and Development with a development model referring to the Wademan and Mckenney model. This research procedure includes preliminary studies, hypothetical model development, model operationalization, and model implementation. Collecting research data using validity assessment techniques and tests of physics competence and critical thinking skills. The data obtained were analyzed by descriptive quantitative. This research shows that (1) Modeling Physics Learning has five phases, namely submission and identification of problems with physical phenomena, provision of prerequisite information, physics modeling, finding solutions, evaluating processes and solutions, (2) The PPF learning model developed in this study is declared feasible because it fulfills the criteria of validity and effectiveness.
The Development of Audio-Visual Learning Media in Islamic Cultural History Subject for Eight Grade Students of MT’s Al-Amanah, Jeneponto
Authors: Ihdiana  , Tolla Ismail , Jumadi
Published: February 2022

The problem in this research were: what is the level of learning implementation and learning achievement of History and Culture of the VIII grade students of MTs Al-Amanah in Jeneponto Regency? The purpose of this study is to describe: An overview of the implementation of learning and learning achievement levels History of Islamic culture in class VIII students of MTs Al-Amanah in Jeneponto Regency. This research was development research (R&D). Development research was research which was oriented towards the development or refinement of a science in overcame a problem directly through an action and self-reflection based on the results of the research, which aimed to improve or enhance educational services that must be carried out in the context of classroom learning. Based on the research results that have been described in the previous chapter, the research results were formulated as follows: Achievement of learning Islamic History and Culture using audio-visual media Students of class VIII MTs Al-Amanah in Jeneponto Regency has a significant increase. Of the 38 students at Madrasa Tsanawiyah Al-Amanah Jeneponto Regency, 20 people got the high category and 13 people got the high enough category after taking action using audio-visual media. Different things before being given the action of using audio-visual media in Islamization learning material activities in South Sulawesi.
Havária jelenség hatása Budapest forgalmára
Authors: Szabó Zsombor , Uti Gábor , Sipos Tibor
Published: February 2022

A városi közlekedés és annak közvetlenül érintő hatásainak vizsgálata, valamint a javaslatok alkalmat adnak a felkészülésre és a komplikációk mérséklésére.