bluuebunny/crossref_metadata_2025 huggingface dataset:
A simultaneous diagnosis of multiple myeloma and Gaucher disease
Authors:   Clinical Hematology Department, Aziza Othmana Hospital, Tunis, Tunisia., Saidi Ines , Neji Hend Ben ,   Clinical Hematology Department, Aziza Othmana Hospital, Tunis, Tunisia., Lakhal Fatma Ben ,   Hematobiology Department, Aziza Othmana Hospital, Tunis, Tunisia., Borgi Wejden El ,   Hematobiology Department, Aziza Othmana Hospital, Tunis, Tunisia., Gouider Emna ,   Hematobiology Department, Aziza Othmana Hospital, Tunis, Tunisia., Meddeb Balkis ,   Clinical Hematology Department, Aziza Othmana Hospital, Tunis, Tunisia.
Published: September 2022

Gaucher disease (GD) is a rare autosomal recessive metabolic disorder caused by the deficiency of the enzyme glucocerebrosidase, required for the degradation of glycosphingolipids. This leads to the accumulation of glucosylceramide and glucosylsphingosine in lysosomal macrophages (Gaucher cells). The diagnosis of GD should be made on the deficiency of the glucocerebrosidase activity (GBA) in leukocytes, fibroblasts, and/or dried blood spots, but also be confirmed through molecular analysis of the GBA gene. GD is linked to an increased risk of cancer in general, and hematological malignancies in particular. Due to an excessive accumulation of glucocerebroside in bone marrow, both cytopenia and bone lesions can be seen in GD, which are clinical presentations that may overlap with multiple myeloma (MM). We report here the case of a patient with synchronous GD and MM, with the description of the evolution.
Discordant GH and IGF-1 levels in a patient with acromegaly and fibrous dysplasia: A case report
Authors:   Assistant Professor of Endocrinology, Skull Base Research Center, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Davoudi Zahra , Farsi Yeganeh ,   Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Mousavinejad Seyed Ali Mousavinejad ,   Assistant Professor of Neurosurgery, Skull Base Research Center, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Jamali Elena ,   Department of Pathology, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Sharifi Guive ,   Professor of Neurosurgery, Skull Base Research Center, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Published: September 2022

Introduction: Follow-up management of patients with acromegaly after pituitary surgery is performed by biochemical assessment of Growth Hormone (GH) and Insulin-Like Growth Factor-1 (IGF1). There is increasing recognition of patients who show discordance results between GH and IGF1. Clinical case: We report on a 38-year-old man with facial and ear pain on the left side. A candidate for canaloplasty, he was referred to our endocrinology clinic because he had symptoms of acromegaly. The clinical suspicion of acromegaly was confirmed using biochemical tests and Magnetic Resonance Imaging (MRI). The patient’s asymmetric facial features and a Computed Tomography (CT) scan of the skull base showed fibrous dysplasia. After transsphenoidal surgery, the patient’s complaints improved. Hypopituitarism did not occur. The patient’s IGF-1 levels were within the normal range during the postoperative follow-up period. However, the GH levels at baseline and after an Oral Glucose Tolerance Test (OGTT) remained high, which indicated discordant GH and IGF1 levels. Because the patient had normal IGF-1 levels and no clinical signs and symptoms, he was followed up every 3-6 months. The GH and IGF-1 discrepancy persisted for 3 years. After 3 years, the IGF-1 levels increased, which resulted in the patient being treated with longacting octreotide. The patient is currently in remission with medical treatment. Conclusion: The interpretation of discrepancy between IGF1 level and GH after OGTT in patients with acromegaly during the follow-up requires efficient management of clinical symptoms and biochemical markers in these patients which need close patient-physician cooperation.
Shot gun eye injuries: Senegalese experience
Authors:   Cité Universitaire Fann Hock Campus A 2-1-8 DAkar/Sénégal., Diagne Jean Pierre , MbaraKa Aly ,   Cité Universitaire Fann Hock Campus A 2-1-8 DAkar/Sénégal., Ba Alassane ,   Cité Universitaire Fann Hock Campus A 2-1-8 DAkar/Sénégal., R Yassine ,   Cité Universitaire Fann Hock Campus A 2-1-8 DAkar/Sénégal., eideros M EQ De M ,   Cité Universitaire Fann Hock Campus A 2-1-8 DAkar/Sénégal., P A Ndiaye ,   Cité Universitaire Fann Hock Campus A 2-1-8 DAkar/Sénégal.
Published: September 2022

Purpose: To describe the cases of eye trauma caused by the use of home-made firearms and to highlight the difficulties of their management. Observations: We admitted five patients (0.16%) with firearm-related eye injuries during the period from January 01, 2010 to January 01, 2022. All our patients were male. The average age was 33.2 years with extremes between 21 and 55 years. The circumstances of occurrence were dominated by attacks with lead as the main traumatic agent in all our patients. The consultation time ranged from one week to three months with a starting visual acuity not exceeding the light perception. The lesions were bilateral in three patients. There was a loss of eyeball function in all patients. Intraocular foreign bodies were found in 80% of cases. All our patients received medical treatment. Two of our patients had received surgical treatment such as extra capsular extraction and anterior vitrectomy. Discussion and conclusion: Shot-gun eye injuries have increased in recent years. Facial screening makes all the severity of these traumas involving the functional prognosis of the eye. Young people in full employment are mainly affected, hence the importance of prevention. Keywords: Eye; Shot weapons; Trauma; Prognosis; Prevention.
Florid squamous papilloma of the tongue
Authors:   Institute of Dermatology, Guangzhou Medical University, Guangzhou 510095, P.R. China., Liang Jing-yao , Li Chang-xing ,   Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, P.R. China., Chen Ping-jiao ,   Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, P.R. China., Zhang Xi Bao ,   Institute of Dermatology, Guangzhou Medical University, Guangzhou 510095, P.R. China.
Published: September 2022

A 47-year old Chinese woman presented with a 2-year history of multiple small flammulated papilloma-liked lesions on her tongue. She has noted an increase of the size and number of lesions within the past month, with significant harsh feeling, but the taste sensation is normal. The physical examination showed diffusely multiple, florid, and slight raised spots in different sizes, measuring from 1 to 3 mm in dimensions, appearing on the dorsal surface and lateral borders of the tongue (Figure 1A and 1B). Incisional biopsy of the lesion area showed papillary mucosal epithelial, dermal superficial collagen bundle and mucous matrix hyperplasia (Figure 1C). She denied any other cutaneous or systemic abnormalities. Based on histopathological examination, a diagnosis of squamous papilloma was made.
Transfemoral tricuspid valve-in-ring implantation: Approach to a challenging clinical scenario
Authors:   Department of Cardiac Surgery, Henri Mondor University Hospital, 94010 Créteil, France., Saiydoun Gabriel , San Sovannarith ,   Department of Cardiology, Henri Mondor University Hospital, 94010 Créteil, France., Deux Jean-Francois ,   Department of Radiology, Henri Mondor University Hospital, 94010 Créteil, France., Boukantar Madjid ,   Department of Cardiology, Henri Mondor University Hospital, 94010 Créteil, France., Gallet Romain ,   Department of Cardiology, Henri Mondor University Hospital, 94010 Créteil, France., Teiger Emmanuel ,   Department of Cardiology, Henri Mondor University Hospital, 94010 Créteil, France.
Published: September 2022

Transcatheter tricuspid valve-in-ring (TVIR) implantation using balloon-expandable valve was an alternative technic to high-risk redo surgery for patients with tricuspid valve (TV) ring repair and symptomatic severe tricuspid regurgitation. In this case, we report a case of unsuccessful transfemoral TVIR implantation with a severe paravalvular leak (PVL) treated successfully with Amplatzer vascular plug.
ANALISIS PENGARUH GROSS PROFIT MARGIN(GPM),RETURN ON ASSET(ROA),DEBT TO EQUITY RASIO(DER) DAN NET PROFIT MARGIN(NPM) TERHADAP PERTUMBUHAN LABA PADA PT. SAT NUSA PERSADA TBK.
Authors: Yuliantin Antin , Aprianti Kartin
Published: September 2022

This research examines empirically the effect of Gross Profit Margin (GPM), Return On Aseet (ROA), Debt To Equty Ratio (DER), dan Net Profit Margin (NPM) to profit growth of companies PT. Sat Nusa Persada Tbk. The  in this research this is all financial statements of PT. Sat Nusa Persada Tbk for 15 from 2007-2021, the  sample used in this study was f10 years from 2011-2020. Sampling was conducted tusing purposive sampling. The analytical method used in this research is quantitative method, with classical assumption test, multiple linear regression, coefficient of determination and multiple correlation, hypothesis testing (T test) and simultaneous test (F test) with using tool of SPSS version 21. The result shows that Gross Profit Margin (GPM), Return On Asset (ROA) has no significant influence to profit growth, while Debt To Equity Ratio (DER), Net Profit Margin (NPM) has significant to profit growth in PT. Sat Nusa Persada Tbk. Based on the simultaneous test that Gross Profit Margin (GPM), Return On Asset (ROA), Debt to Equity Ratio (DER) dan Net Profit Margin (NPM) has a significant effect on profit growth in PT. Sat Nusa Persada Tbk.
PENGARUH PENGAWASAN DAN PENILAIAN KINERJA TERHADAP PRODUKTIVITAS KERJA KARYAWAN PADA PT. TUNAS BARU LAMPUNG (TBK) BANYUASIN
Authors: Lerian Niken , Darmawati Tri , Heryati Heryati
Published: September 2022

Penelitian ini bertujuan untuk mengetahui pangaruh pengawasan dan penilaian kinerja terhadap produktivitas kerja karyawan pada PT. Tunas Baru Lampung (Tbk) Banyuasin. Teknik pengumpulan data yang dilakukan dalam penelitian ini adalah observasi dan penyebaran kuesioner  kepada 57 orang karyawan. Teknik analisis data menggunakan analisis regresi linier berganda, koefisien determinasi dan pengujian hipotesis dengan menggunakan uji t dan uji F. Berdasarkan pengelolaan data diperoleh persamaan regresi linier berganda Y = 17.916 +0,454X1 + 0,99X2  dan hasil koefisien determinasi R2 sebesar 0,341 atau 34,1% dengan begitu pengawasan dan penilaian kinerja mempengaruhi produktivitas kerja sebesar 34,1% sedangkan sisanya 65,9% diberikan atau ditambahkan ke berbagai variable  tidak terkonsentrasi pada penelitian  ini.
PENGARUH HARGA TERHADAP KEPUASAN PELANGGAN PRODUK KELOM SHENY DI KOTA TASIKMALAYA
Authors: Arif Arif , Pauzy Depy Muhamad
Published: September 2022

This study aims to examine the effect of price on customer satisfaction of Kelom Sheny products in Tasikmalaya City. In this study using a quantitative approach with a simple random sampling technique with 100 respondents. The results of the validity and reliability test showed that Cronbach's Alpha coefficient was more than 0.60. Then, linear regression analysis with t test value is 0.874. The value of r square is 0.008 or the effect of price on customer satisfaction is only 0.8%, it shows that 99.2% of customer satisfaction is influenced by other variables. Based on the results of these data, the effect of price on customer satisfaction has no significant effect
ANALISIS MANAJEMEN OPERASIONAL PADA STANDAR PROSEDUR CV. ADHI JAYA CONSULTANT
Authors: Jakaria Ade , Isfianadewi Dessy
Published: September 2022

This study aims to analyze the application of Standard Operating Procedures on CV. Adhi Jaya Consultant. This study uses a qualitative approach and data collection methods in the form of observation, interviews and documentation. Results regarding the implementation of the seven main points in Standard Operating Procedures. (1) efficiency, there is still waste in terms of working time. (2) consistent, in the implementation of employees it is quite consistent to be guided by the existing SOPs. (3) minimizing errors, training is carried out before carrying out the work. (4) problem solving, the existing SOPs are detailed enough to find the root of the problem if there is a lack of data, but the SOP does not contain sanctions, problem solving, termination of employment and conflict resolution. (5) labor protection, the existing SOP already regulates work safety for employees in the field, but the SOP does not contain detailed rules regarding social security and compensation for employees. (6) work map, the existing SOP only regulates the workflow, where an executor is accompanied by several assistants in their work. (7) defense limits, monitoring carried out every month by the relevant agencies to find out whether the progress of project implementation is in accordance with existing SOPs or not
Narrativas de Avenca: o teatro como experiência emancipatória
Authors: Ferracioli Bruna Rafaela
Published: September 2022

Este trabalho investiga de que forma o processo de concepção teatral pode contribuir para a formação emancipatória de artistas-pesquisadores da área do teatro. Tal investigação parte da análise reflexiva da peça E a Avenca partiu, uma adaptação do texto original - o conto: Para uma avenca partindo, de Caio Fernando Abreu (2010) -, para o qual define-se um posicionamento artístico e político, que culmina, posteriormente, na dramaturgia textual e abordagem cênica utilizadas no espetáculo.
Cena-memória: poética de atuação de um ator dançarino
Authors: Santos de Jesus Milton
Published: September 2022

Este estudo associa uma produção artística a uma reflexão teórica, que parte de um reencontro com minha trajetória de ator dançarino. Compõem a pesquisa fragmentos de cinco obras cênicas realizadas em Belém/PA, entre 2005 e 2013, posteriormente deflagradas em cenas- memórias. O objetivo é estudar a criação autoral na dança e no teatro contemporâneos, por meio de uma perspectiva de história de vida, de dramaturgia pessoal e dramaturgia da memória, buscando refletir identidade e biografia. Avançaremos no entendimento de uma pesquisa de si mesmo, autorreferente, autobiográfica e dramatúrgica através de reflexões provocadas por Wlad Lima, Lícia Sanchez, Janaina Leite, Carolina Laranjeira, Ana Pais, Ciane Fernandes e Caroline Delgado e outros. Interessa a este trabalho colaborar com o debate sobre formação, autonomia e poética de atuação do artista cênico; compartilhar os procedimentos de criação da performance Curral de Peixe; e por fim, a noção de cena-memória.
Memórias transatlânticas
Authors: Araujo de Santana Rafaela
Published: September 2022

Esta pesquisa consiste em revisitar as memórias que atravessam a minha corporeidade negra em diáspora na cidade de São Paulo. Para essa escrita me apoiei no método de pesquisa elaborada pela pesquisadora Inaicyra dos Santos que “visa primeiro ao aprendizado do conhecimento revisado do que somos, do nosso local de origem, e, segundo, ao conhecimento dos outros, para que com isso, possamos construir um saber de dentro para fora e de fora para dentro” (SANTOS, 2019). Nesse trabalho usei como base também o conceito de oralitura, cunhada pela doutora Leda Martins (2003), e a cosmologia africana dos bantu-kongo, estudada por Bunseki Fu Kiau e, traduzida na tese de doutorado do Tiganá Neves (2019). Essa pesquisa visa compartilhar também uma possibilidade ou, um caminho possível de (re) encontro, (re) conexão e (re) existência.
Um respiro em meio ao caos: projetos virtuais no contexto pandêmico de covid-19
Authors: Matos Dantas Stephanie Caroline
Published: September 2022

Este artigo é dedicado ao estudo do projeto virtual PalhAçaí, realizado pelo grupo Teatro Ruante, de Porto Velho/RO. Trata-se de uma pesquisa descritiva qualitativa com o objetivo de investigar e refletir acerca das contribuições do projeto PalhAçaí para minha formação acadêmica como professora, pesquisadora e artista. E ainda, refletir de que forma o PalhAçaí pode contribuir e auxiliar profissionais e estudantes das artes. Para isso, inicio com a fundamentação teórica acerca da figura do palhaço, apresentando um pouco sobre sua origem, para depois discutir a diferenciação entre clown e palhaço. Apresento ainda a dupla cômica clássica: o Branco ou sério e o Augusto ou engraçado. Depois, relato minha jornada virtual no projeto PalhAçaí. No decorrer da pesquisa, concluí que o projeto PalhAçaí contribuiu para o entendimento da importância do processo criativo e pedagógico online, trazendo uma nova perspectiva acerca do uso das plataformas virtuais.
Lengua y patria de la filosofía
Authors: Guarneros Aldo
Published: September 2022

This essay offers a few meditations on what the language and the homeland repre sent for the philosophy. These thoughts are motivated by the publication, in the present issue of Estudios, of the Essays from Catalan by Eduardo Nicol, philosopher who was forced to produce his works not only from exile from his homeland, but in a, to a certain extent, foreign language. The aim, nonetheless, is not to propose the corresponding questions from a particular nationalist point of view, but from a universal metaphysical one, activity to which Nicol devoted himself throughout his entire work.
Evaluation of biofilm formation and associated slime encoding determinants in Staphylococcus aureus isolated from clinically diseased pets
Authors: Syame Sohier M. , Elshabrawy Mona , Abouelhag Hussien A. , Ismail Randa Mohamed , Farahat Engy , Gaber E. S. , El-Hewairy Hanan M. , Hakim Ashraf
Published: September 2022

Staphylococcus aureus (S.aureus) is an important zoonotic pathogen implemented in various hospital, community as well as livestock infections. Pets as dogs and cats have increased their close social relation with human leading to significant elevation in transmission of zoonoticmultidrug resistant virulent pathogens.Diplex polymerase chain reaction was applied on ten clinical Staphylococcus aureus isolates obtained from wound and nasal samples from dogs and cats for detection of twoslime formation encoding genes;icaA andicaD. The positive genes carrying isolates were encouraged to produce biofilm and evaluated phenotypically by cultivation onto Congo red medium. Quantitative assessment was done using a microtiter plate assay, also the formed biofilm examined by fluorescent and scanning electron microscopy. Four out of tested tenStaphylococcus aureus isolates were found to harbor the two genes separately.The four isolates displayed positive biofilm production onto Congo red medium while only three isolates produced biofilmin sterile polystyrene 96-well microtiter plate. One isolate associated dog infection developed strong biofilm formation which examined byboth fluorescent and scanning electron microscopy.Staphylococcus aureus isolates obtained from diseased dogs and cats can produce biofilm that increasing their virulence and pathogenicity as well as public health concern.
DESIGN, DEVELOPMENT AND EVALUATION OF ALOGLIPTIN AND METFORMIN HYDROCHLORIDE BILAYER TABLET
Authors:   Department of Pharmaceutics, Sandip Institute of Pharmaceutical Sciences, Mahiravani, Nashik – 422 213, Maharashtra, India, S. Jat Deepak , G. Talele Swati , A. Bakliwal Akshada , G. Jadhav Anil
Published: September 2022

The objective of the present work was to formulate and evaluate bilayer tablets of alogliptin and metformin HCl. Combining alogliptin with metformin HCL gives additional benefits in comparison with either drug alone and could be considered for patients whose quality of life is impaired by diabetes mellitus. The study was performed to design bilayer tablets of alogliptin immediate release layer and metformin HCl sustained release layer by wet granulation method. The immediate release layer comprised Crospovidone superdisintegrant and sustained release layer comprised HPMC K4M as rate release controlling polymers and PVPK30 was used as binder for both layers. The in vitro release of drug from the formulations was studied in 0.1N HCl acidic buffer and pH 6.8 phosphate buffer, and it was found that the prepared sustained release layer tablets were able to sustain the release of the drug up to 12 h and in vitro studies of alogliptin shown more than 80% of drug was released within 30 min. As per ICH guidelines, accelerated stability studies were carried out and results were found within the range. The release of alogliptin follows a zero order release model and the release of metformin HCl follows Higuchi model release.
NOVEL SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF ABACAVIR SULPHATE, LAMIVUDINE AND DOLUTEGRAVIR SODIUM IN DOSAGE FORM
Authors:   Research Scholar, Department of Pharmacy, Ganpat University, Ganpat Vidyanagar, Mehsana - 384 012, Gujarat, India, M. Rathod Sapna , U. Patel Paresh
Published: September 2022

Double Divisor ratio spectra derivative method was developed and validated for a ternary mixture containing abacavir sulphate (ABA), lamivudine (LAM) and dolutegravir sodium (DOL) in distilled water. The method is based on dividing the absorption spectra of ternary mixture by the sum of absorption spectra of two of the three components and then taking the first derivative of the ratio spectra. The linear range was found to be 5 – 40 µg mL-1 for ABA, 4 – 20 µg mL-1 for LAM and 1 - 20 µg mL-1 for DOL. The mean % recoveries were found to be in the range of 98.85 – 100.93 % for ABA, 99.65 – 99.38 % for LAM and 100.29 – 98.67 % for DOL. ICH guidelines were used to validate the developed method. The proposed method can be successfully applied to pharmaceutical formulations as it is rapid, simple, sensitive, selective and accurate.
SIMPLE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR SIMULTANEOUS QUANTIFICATION OF SAXAGLIPTIN AND DAPAGLIFLOZIN IN RAT PLASMA
Authors:   Department of Pharmaceutical Analysis, Sri Adichunchanagiri College of Pharmacy, Adichunchagiri University, B G Nagara, Nagamangala, Mandya -571 448, Karnataka, India, Kurian Aksa , T. N Rekha , C Bhagyalakshmi , S. Ahmed Syed , T. Pasha Yunus , B Ramesh , Majumder Manish
Published: September 2022

A simple HPLC method was developed for the simultaneous estimation of saxagliptin and dapagliflozin in rat plasma. The separation has been achieved by C8 Eclipse plus column (25cm x 5cm x 4.6µ) at 1 mL min-1 flow rate. The mobile phase comprises of 0.01 % trimethylamine in water and methanol (40:60 V/V). The effluents were monitored at 228 nm. The retention times were found to be 4.243 min and 11.304 min for saxagliptin and dapagliflozin, respectively. The quantification ranges were found to be linear over 25-175 ng mL-1 and 100-700 ng mL-1 for saxagliptin and dapagliflozin, respectively. Regression equations of saxagliptin and dapagliflozin were found to be y = 594.84x - 801.14 and y = 128.6x - 348.57 with regression coefficient (R2 ) 0.9988 and 0.9963, respectively using weighting factor of 1/x0 , 1/x, 1/√x, and 1/x2 . The percentage recoveries were 81.51±1.276 to 86.23±2.012 and 81.48±2.487 to 85.40±2.145 for saxagliptin and dapagliflozin, respectively. This reported method was extensively validated according to US-FDA guideline.
POSSIBLE DESTRUCTION OF SARS-COV-2 BY SODIUM DEOXYCHOLATE
Authors:   School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya Airport Road, Gandhi Nagar, Bhopal – 462 033 Madhya Pradesh, India, Pandey Durga , Jain Deepti , Pandey Girijesh , Jain Surendra
Published: September 2022

The objective of this study was to focus on the antiviral activity of a bile salt, namely sodium deoxycholate. There is a possibility of killing severe acute respiratory syndrome corona virus-2 due to the destruction of its protein and lipid overcoat by sodium deoxycholate alone or with drugs those showing response against severe acute respiratory syndrome corona virus-2. Destruction of inner viral constituents and hence disintegration of the virion is possible at very small concentration. This study can be an important platform for further investigations.
COMPARATIVE QUANTITATIVE ESTIMATION OF COLCHICINE IN CORMS OF DIFFERENT COLCHICINE BEARING PLANTS USING HPLC AND HPTLC METHOD
Authors:   R&D Centre, Hindustan Farm Direct Ingredients Limited, Una - 177 209, Himachal Pradesh, India, Sapra Sameer , Bhalla Yashika , Chopra Bhawna , K. Dhingra Ashwani
Published: September 2022

Colchicine is an alkaloid which has been reported to possess anti-gout, anti-rheumatic, antiparasitic and anticancer potential. It is a toxic natural product obtained from plants of the genus Colchicum (C. autumnale and C. luteum), Gloriosa superba, and Iphigenia indica. In the present study, three different methods (percolation, sonication, and Soxhlation) of the extraction for colchicine from three different plants (C. luteum, G.superba, and I. indica) have been studied.The concentration of colchicine in different prepared extracts was quantified using high-performance liquid chromatographic (HPLC) and high-performance thin-layer chromatographic (HPTLC) methods. The developed and optimized chromatographic method was validated according to the International Conference on Harmonization (ICH) guidelines for linearity, precision, accuracy, specificity, sensitivity, recovery and robustness. The developed methods (HPLC and HPTLC) were applied for the comparative quantitative estimation of colchicine in three different plant extracts. Both the methods were found to be simple, selective and accurate with a wide range of linearity, hence useful for the quantification of colchicine content in different formulations containing colchicine-bearing plant extracts. Due to its toxic nature, the quantification of colchicine will play an important role in quality control of several herbal and unani formulations containing colchicine-bearing plant extracts. The present studies clearly indicate that both G. superba and C. luteum contain about 0.2 %w/w of colchicine.
SYNTHESIS OF SOME NEWER THIAZOLIDINONYL QUINAZOLINONES AND AZETIDINONYL QUINAZOLINONES AS POTENT ANTI-INFLAMMATORY AGENTS
Authors:   Medicinal Chemistry Laboratory, Department of Chemistry, Meerut College, Meerut-250 001, Uttar Pradesh, India, Nancy  , Chaudhary Sakshi , Archana
Published: September 2022

3-Substitutedphenyl-2-bromomethyl-6-substituted quinazolin-4(3H)-ones (7-10) were treated with hydrazine hydrate to give 3-substitutedphenyl-2-hydrazinomethyl-6-substituted quinazolin-4(3H)-ones (11-14). Compounds 11-14 were condensed with various aldehydes to afford 2-substitutedbenzylidene hydrazinomethyl-3-substitutedphenyl-6-substituted quinazolin-4(3H)-ones (15-22). Cycloaddition of compounds 15-22 with thioglycolic acid and triethylamine / chloroacetyl chloride yielded 2-[(4’-oxo-2’ -substitutedphenyl-thiazolidin-3’-yl)-aminomethyl]-3-substitutedphenyl-6-substituted quinazolin-4(3H)- ones (23-30) and 2-[(4’-oxo-3’-chloro-2’-substitutedphenylazetidin-1’-yl)-aminomethyl]-3- substitutedphenyl-6-substituted quinazolin-4(3H)-ones (31-38), respectively. The structures of these compounds have been elucidated by elemental (C, H, N) and spectral (IR, 1H-NMR) analysis. All the above mentioned compounds were evaluated for their anti-inflammatory activity, ulcerogenic activity and acute toxicity study. Compound 27 was found to be most potent amongst all the newly synthesized compounds. This compound also exhibits less ulcerogenic activity and ALD50 is >2000 mg kg-1 p.o.
INNOVATION AND PATENTS RECEIVING THE GOVERNMENT'S ATTENTION
Authors:   Editor, Indian Drugs
Published: September 2022

Dear Reader, Inaugurating the Grand Finale of the Smart India Hackathon, 2022 and addressing the 15000 finalists of the Hackathon, the Honourable Prime Minister of India, Shri Narendra Modi made a clarion call for research and innovation and appealed to make innovation a "way of living" with increasing acceptance in society, especially among the research community. The Future of India will be realised and recognised through innovative research and commercialisation of innovation, he said. Strong governmental support through appropriate organisations was promised for encouraging innovation. It is heartening, said the PM, that India is making rapid strides in Intellectual Property generation through ideation and converting them to practical applications.
GENETIC EVALUATION OF INDIGENOUS AND EXOTIC WHEAT GERMPLASM BASED ON YIELD RELATED ATTRIBUTES
Authors: AMMAR A , Ghafoor S , AKRAM AUA , ASHRAF W , AKHTAR S , NAWAZ MS , ZAGHUM MJ , KHAN MY , AAS MA , SHAHeen A , KHALID MN
Published: September 2022

Wheat is highly self-pollinated crop and main staple food of the world. Yield is one of the main breeding objectives in the wheat crop. Plant breeders are focusing on the development of new lines with increased yield, resistant against biotic and abiotic factors and having more nutritional values. The goal of the current research was to identify acceptable crossings for further investigation by determining the type of gene action (genetic effects) and combining ability of parental genotypes for morphological features. This approach was used to evaluate three lines, namely Ujala-2016, Johar-2016, Galaxy-2013 and four testers’ viz. XJ22, XJ23, XJ24 and XJ25. Collected data were subjected to line × tester analysis. Among parents as lines genotype Johar-2016 found good general combiner for studied traits. While among testers XJ25 proved to be the best general combiner for studied traits. Similarly, cross combinations hybrid XJ25 × Galaxy-2013 performed best as specific combiner. It was noticed that SCA variance was greater than GCA variance for all factors studied in wheat except for grains/spike. The superior genotypes and crosses can be further tested in yield for development of improved wheat varieties.
IMPACT OF HEAT STRESS ON AGRO-MORPHOMETRIC AND FIBERRELATED TRAITS IN INDIGENOUS UPLAND COTTON GENOTYPES UNDER SEMI-ARID CONDITIONS
Authors: ASLAM MZ , SAJJAD MH , YOUSAF MI , HUSSAIN S , SHAH SAS , BHATTI MH , HUSSAIN S , GHANI A , IBRAR I , AKRAM M , RAZAQ A , MEHBOOB A , AKHTAR S , ZAFAR A , AKHTAR I , SHAH SWH
Published: September 2022

To understand the impact of heat stress on agro-morphological and fiber quality-related traits in cotton, nine locally developed cotton genotypes were grown under heat stress conditions (Late sowing) at the cotton research station, Bahawalpur. Genotypes were laid-out under randomized complete block design (RCBD) in triplicates, where plant to plant and bed to bed distance was maintained as 30 cm and 75 cm, respectively. Data was collected from selected, guarded plants for agronomic as well as fiber quality-related traits. The resultsunveiled the presence of significant variations for studied traits under high temperature conditions. The correlation analysis revealed the significant association of seed cotton yield with plant population (0.403**), monopodial branches per plant (0.267**), fiber strength (0.070*), CLCuV incidence percentage (-0.475**), fiber length (-0.447**), nodes per plant (-0.186*), sympodial branches per plant (-0.186*), and fiber fineness (-0.077*). The multivariate approaches i.e., Principal component, biplot, and cluster analysis classify and characterize cotton genotypes on the basis of their heat tolerance capacity. Moreover, these multivariate analyses showed that BH-377, BH-272, and BH-283 were the most heat tolerant genotypes while BH-283 and BH-284 showed comparatively good CLCuV tolerance. Therefore, these genotypes should be recommended for sowing in heat and CLCuV effected areas of Pakistan after their large-scale, multilocation testing.
We Are Not Here
Authors: Cavalletti Andrea
Published: September 2022

The second chapter is dedicated to the original theory of vertigo conceived by the philosopher and historian of art and ideas Robert Klein. One the one hand, Klein’s theory offers a key to interpreting the film. On the other hand, it recalls the themes of subjectivity and habitus in Husserl’s phenomenology as well as in the philosophies of Sartre and Merleau-Ponty. The concept of vertigo concerns space and time, the ego and intersubjectivity itself.
Explicit
Authors: Cavalletti Andrea
Published: September 2022

Abstract and Keywords to be supplied.
Ecology with Totality: The Case of Morton’s Hyperobjects and Klein’s This Changes Everything
Authors: Bellamy Brent Ryan
Published: September 2022

In the collection’s closing essay, Brent Ryan Bellamy argues for the necessity of totality thinking in the fight against climate catastrophe. Demonstrating how two of the most well-recognized and well-respected contributions to the climate thinking fail to grasp the relationship between capitalist and climate crisis, he argues that they are both expressions of the same dynamic such that capitalist reproduction will soon make social reproduction impossible thanks to ocean acidification, fluctuating sea levels, and droughts and desertification, and violently turbulent storms. This moment demands a commensurate political response, one that addresses environmental devastation and its uneven application across populations. Without integrating a critique of capitalism, the possibility of overcoming climate change to ensure the survival of humanity all but disappears.
Death in Place
Authors: Heslop Kate
Published: September 2022

Poetry in kviðuháttr shares a common interest in place-based commemoration. Ynglingatal re-mediates topographically anchored memory in poetic form by recounting local tales of royal death- and grave-sites, most importantly the site of Uppsala, where the destroyed great hall left a memorial scar on the landscape. Ynglingatal’s many placenames form mnemonic itineraries along land and sea routes as the sequence of doomed kings is traced from the temporally and spatially distant rulers of Svíþjóð to the recent local rulers of Viken. The poetic speaker’s autopsy of the gravesites of the Viken kings claims an authority which is retrojected over the entire sequence, attaching communal memories to the name of his patron, Rǫgnvaldr. Carolingian royal iconography probably influenced the development of commemorative media in Scandinavia, and the patterns identified in Ynglingatal can be traced in the subsequent history of kviðuháttr poetry for Christian patrons.
Conclusion
Authors: Heslop Kate
Published: September 2022

The medial perspective unsettles the author-centrism of much classic work on skaldic poetry. In its place intersubjective compositional labor and interferences between media come into focus, whether the shared landscape of memories transmitted in kviðuháttr, competing acts of imaginative visualization in skaldic picture poems, or the resounding, semantically proliferating soundscape of dróttkvætt encomium. In this more processual account of skaldic poetics, the data of manuscript transmission can no longer be discounted as textual corruption; rather they are the traces of a complex and ramifying practice of re-writing. With the passing of time, knowledge of specific reference fades and the form comes forward. Following the new philological turn away from recension reveals the skaldic texts in the surviving manuscripts as a much larger and later corpus than that of the reconstructed archetypes. The written transmission of skaldic poetry in the historically specific medial setting of vocalité is characterized, like many medieval text traditions, by a profound openness and fluidity.
Introduction
Authors: Katz Wendy Jean
Published: September 2022

The introduction surveys nativist iconography, focusing on the Order of United Americans, a fraternal association that barred immigrants, because Walcutt contributed to their newspaper, the Republic. Editor and Know-Nothing congressman Thomas R. Whitney adopted visual cues—youthful ardor, brotherhood, stars and stripes—that evoked not just patriotism, but an ethic of mutualism. This ethic stemmed from artisan culture’s resistance to capitalist individualism, and it also manifested itself in benevolent fraternal orders like the Odd Fellows. It was coopted by the Know-Nothings to support their platform favoring Compromise (with slavery) for the sake of the national Union and restrictions on citizenship that excluded foreigners. It also emerged in historical pictures by Walcutt and other artists (Tompkins H. Matteson, Frederick A. Chapman) that demonstrated that the patriotic “spirit of ’76” was one of Protestant brotherhood.
“The Same Patriotism… as Any Other Americans”
Authors: Hatch Reilly Ben
Published: September 2022

American imperialism brought to light many tensions within Mormonism’s conception of the American state. This paper explores how the church responded to American imperial policy at the end of the nineteenth century, in relation to the residual pressures of Reconstruction in Utah. Even though Mormons boldly claimed to be ultra-patriots and servants of the nation, they maintained a loyalty to divine law, which commanded them to abstain from warfare when possible and to honor the liberty of all peoples. These commitments were tested and set aside during Mormon involvement in the Spanish-American War, which served as a curative that solidified American nationalism as an essential component of Mormon identity and set a precedent for Mormon political life in the early twentieth century.
An Empire of Reconstructions
Authors: Jackson Justin F.
Published: September 2022

This chapter examines through comparative history the U.S. military occupations in the South after the Civil War and Cuba following the war with Spain. It explores continuity and change in the culture of armed occupation, from problems of racial equality and nation-building to economic development. The Cuban occupation remade the original nineteenth-century meanings of reconstruction, from an internal process of social or national transformation, to one in the twentieth century involving the reshaping of capitalist nations abroad.
Survival as Autoimmunity
Authors: Trumbull Robert
Published: September 2022

Chapter 3 traces the implications of Derrida’s thinking on life death in his work after 1990, exploring how his engagement with Freud allows us to fully understand the crucial deconstructive notions of survival and the autoimmunity of life. In particular, it shows how, from Specters of Marx on, we begin to see a shift in Derrida’s thought, whereby the logic of life death is rearticulated into a thinking of life as survival or living on. It then demonstrates how Derrida’s activation of Freud, particularly the figure of the death drive, sheds light on this concept and its relation to what Derrida calls autoimmunity. The chapter shows that the logic of autoimmunity has its most forceful potential in the thought of life as autoimmune, where the basic conditions of the living are thought in terms of processes of internal division and contamination, on the one hand, and originary exposure to destruction, on the other. The chapter concludes by distinguishing this interpretation from the reading of Derrida and Freud offered by Martin Hägglund, which focuses only on thinking exposure as the opening to an unpredictable future.
Empire: Turns and Returns
Authors: Gonzalez Vernadette Vicuña
Published: September 2022

This essay delineates the indispensability of empire as an analytic in Filipinx American studies, how the field’s engagement with empire has been influenced by developments in fields like postcolonial studies and American studies. It scrutinizes both the utility and limits of empire as a foundational lens or thematic order, taking into account critiques raised by fields like Indigenous studies and settler colonial studies, and including within such critiques a (re)consideration of the continued deployment of “American” in Filipinx American studies.
Empire as the Rule of War and Fascism
Authors: Balce Nerissa S.
Published: September 2022

This essay examines how empire has been taken up in Filipinx American studies, specifying how scholars in the field have approached empire as a political idea and as culture that registers its ongoing legacies, what is described here as the afterlives of empire. It also reflects on the current manifestations of empire in the form of fascism and the rule of war, epitomized by the US global war on terror and the Duterte regime in the Philippines.
Empire: US States at the Intersection of Diaspora and Indigeneity
Authors: Saranillio Dean Itsuji
Published: September 2022

This essay situates an analysis of empire as emerging out of processes of settler colonialism, advancing the notion that empire is a function of the “failures” or unsustainability of settler colonialism and capitalism. It argues that a consideration of the rise of the US as the largest militarized empire in world history cannot be disentangled from the establishment of white settler colonies.
Liminal Services: Third Spaces of Being within the United States
Authors: Poblete JoAnna
Published: September 2022

This essay investigates how Filipinxs have been situated in the interstices of US political, economic, social, and cultural systems, or what is described here as the “third spaces of being within the United States.” Using this analytical lens compels Filipinx American studies to view Filipinx American liminality as a basis for advancing comparative, even cross-racial, analyses of Filipinx American history.
Pag-uugat at Paglalayag (Roots and Journeys): Filipino Language Learning and Activism
Authors: Barrios Joi
Published: September 2022

Socially and politically meaningful work for most Filipinx Americans—whether in reference to their multiple forms of activism or their collective quest to rediscover roots—is equivalent to, even impossible without, language learning, language use, and most significantly, language teaching. This essay is invested in underscoring the import of language as a site of politics, so it deploys an arsenal of narratives that depict the powers of code-switching, critical pedagogy, and poetry in engaging with struggles for self-determination and sovereignty.
A Greek American Vice President?
Authors: Luconi Stefano
Published: September 2022

This chapter examines Italian Americans’ response to Spiro Agnew’s candidacy for vice president in 1968 and 1972 as a case study to assess the influence of ethnic and racial factors on their electoral behavior. Republican presidential candidate Richard M. Nixon slated Agnew as his running mate in 1968 to win the white ethnics’ vote. But Agnew was also chosen over John Volpe, the governor of Massachusetts and a rising star in the Italian American political universe. Consequently, Agnew’s candidacy was likely to dissatisfy voters of Italian background with a strong ethnic consciousness. However, political retaliation against Nixon out of ethnic redress was kept to a minimum and the Republican presidential candidate underwent a significant increase in his share of the Italian American vote in comparison with his 1960 unsuccessful presidential bid. Nixon further consolidated his following among Italian American voters in 1972, as further evidence of the latter’s whitening.
Afterword
Authors: Gabaccia Donna R.
Published: September 2022

The afterward places the volume in the context of the academic response to single-group immigrant studies. The author points out the merits of more focused comparative studies of two or more groups, and she considers the benefits of having a generation of scholars fluent in one or more immigrant languages. She discusses authorial positionality and points out the analytical significance of considering three different aspects of authorial positionality in this volume.
Introduction
Authors: Teo Tze-Yin
Published: September 2022

The introduction discusses the book’s key argumentative moves and provides a guide to the body chapters at the end. The central argument traces a difficult and transformative politics of decoupling meaning and value from the work of translation, which paves the way for a poetics of equivalence. The argument is contextualized by connecting the formation of meaning to capitalist-colonial logics of value-assignation, as routed through the political aesthetic of abstraction. It then goes on to address how related modes of thinking have been addressed in critical work in transpacific studies, modernist literature, modern Chinese literary studies, Asian and global studies, and Asian American studies. The argument is anchored by a reading of a very short fictional story by the Republican-era Chinese reformer Hu Shi.
Transpacific Abstraction
Authors: Teo Tze-Yin
Published: September 2022

The chapter assembles a comparative archive for the book’s framing account of abstraction: a theory and technology of translation at the turn of the century exemplified by two writers who aligned Chinese writing with modernist poetics. Their work formalized the means by which the abstractions of literary equivalence acquired the semblance of cultural capital. The first is Ernest Fenollosa, an American art historian, ambassador, and sinologist who authored The Chinese Written Character as a Medium for Poetry (1906), an important influence for Ezra Pound. The chapter’s second subject is Hu Shi, a reformist advocate of the Chinese baihua vernacular movement in the May Fourth movement—and one of few Chinese thinkers directly interested in the reformatory possibilities represented by the free verse of Anglo-American modernist poetry, recorded in his US diaries as a student in the 1910s. In close readings comparing their theories of linguistic and cultural confrontation, the chapter argues that their translations mediate speech with writing, and sound with image, to authorize the ideological formations shaping a Sino-US transpacific politics of translation. Other texts considered include Hu’s “Dream and Poetry,” “Some Modest Proposals for the Reform of Literature,” and a translated poem “Hope.”
Resounding Events
Authors: Connolly William E.
Published: September 2022

A story of the experiences and experiments of one academic theorist from the American working class who probes how events resound into memory and thinking; such resonances sometimes help us to forge new concepts adjusted to emergent situations. Connolly says memory consists of recollections, organized dispositions without recollection, and remains—all can be activated by events and feed into thought. In focusing on the strange efficacies of diverse events such as the coma of his father, the experience of McCarthyism, tensions between working class life and norms of the academy, anti-war protests, the resurgence of white evangelicalism, the growing disaffection of the white working class, his sister’s experience with white workers shifting to Trump, the neoliberalization of the university, the rise of aspirational fascism, and the acceleration of the Anthropocene, Connolly examines how events jolt and animate thinking. He reviews tactics to spur creative thinking. This book thus explores how engaged intellectuals can become worthy of the events they encounter.
The New Fascist Revolt
Authors: Connolly William E.
Published: September 2022

This chapter draws upon the life of his younger sister in Flint to explore how aspirational fascism established roots in Michigan and exploded into the Trump regime. It reviews the attractions of Trumpism to a white working class, particularly evangelicals, who seek scapegoats to hold responsible for hard times they have experienced during the hegemony of neoliberalism and its periods of economic crisis. The chapter explores the attractions of denialism with respect to race, climate change, and a viral pandemic to this spiritual cohort.