bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of Knowledge and Performance of Village Health Volunteers after Expanding Their Responsibilities in Bago Region, Myanmar, 2017
Authors: Than Wint Phyo , Nyein Aye , Thi Aung
Published: May 2023

With declining malaria morbidity in recent years, the National Malaria Control Program, in 2017, expanded Village Health Volunteer (VHV) responsibilities with the integration of other diseases, including dengue haemorrhagic fever, lymphatic filariasis, tuberculosis, leprosy and HIV/AIDS; and changed their name to Integrated Community Malaria Volunteer (ICMV). This study aimed to assess VHV's knowledge and performance before and after integration and to identify challenges. VHV’s knowledge was assessed with an uncontrolled pre- vs. post-intervention study, and malaria-related performance was assessed with a pre- vs. post-intervention with a non-randomized comparison group. The number of suspected malaria cases blood tested were compared in an intervention township (Kyauktagar) and comparison township (Daik-U). Data were collected by face-to-face interviews and review VHV’s reports and patient registers. The VHV attrition rate was 5% (4/86) over 3 months. All knowledge scores increased significantly after training. However, follow-up knowledge scores were still relatively low. The only difference in reporting status between pre- and post-integration was in timeliness, which was significantly better post-integration. Blood testing was increased in the intervention township. ICMVs had no challenges in malaria activities but some difficulties on reporting forms for other diseases. In conclusion, VHV performance improved in malaria-related aspects after the training. This will support malaria elimination efforts but their performance for non-malaria diseases should be re-evaluated.
Epidemiological Characteristics and Medical Visits of the First 58 COVID-19 Deaths, January–June 2020, Thailand
Authors: Chailek Chanatip , Taweewigyakarn Pantila , Yimchoho Nirandorn , Saritapirak Nipapan , Namwat Chawetsan , Sawanpanyalert Narumol
Published: May 2023

During the first wave of the coronavirus disease (COVID-19) epidemic in Thailand, 3 Jan to 22 Jun 2020, there were 3,151 confirmed cases and 58 related deaths. This study aimed to describe epidemiological characteristics of the deaths and explore risk factors using a retrospective cohort study design. A COVID-19 related death was defined as a confirmed COVID-19 case who died from a clinically compatible illness. We collected data from investigation reports and medical records using a semi-structure questionnaire and retrieved secondary data from the Department of Disease Control’s database. Of the 58 deaths, the median age was 58 years (interquartile range (IQR) 50-70), 44 were male, and underlying disease was found in 44, hypertension being the most common. The median time from onset to diagnosis date was 7 days (IQR 5-9) compared to 4 days (IQR 2-7) in recovered cases. Six were nosocomial infections and of the remaining 52, 36 had visited a medical facility at least once before they were hospitalized. Male, elderly, and delayed diagnosis were found to be positively associated with death. Early detection of COVID-19 cases should be strengthened in health care facilities throughout Thailand.
Investigation of Foot-and-Mouth Disease Outbreaks in Dairy Cattle from Kageshwari and Shankharapur Municipalities, of Kathmandu, Nepal and Associated Risk Factors from March to April 2020
Authors: Kumar Shahi Manoj , Boonyo Khemmapat , Wongphruksasoong Vilaiporn , Upadhyaya Mukul , Rana Sujan , Karki Surendra , Kafle Samjhana K. , Kafle Sharmila
Published: May 2023

Foot and mouth disease (FMD) is endemic in Nepal and significantly impacts the livelihood of farmers, national economy, and trade of Nepal. However, outbreak investigations are not frequently conducted, and there have been limited studies to understand the associated risk factors. A case-control study was performed in dairy cattle farms of Shankharapur and Kageshwari Municipalities, Kathmandu from March to April 2020 to describe the outbreak and identify the risk factors associated with FMD. There were 31 case farms, while 62 farms were selected as control farms (1:2). The information from case and control farms was collected by semi-structured questionnaire survey through field visits and observations. The univariable and multivariable logistic regressions were performed. The farm-level prevalence of FMD was 25.2% (n=31/123). Among the FMD affected farms, the proportion of positive farms in Shankharapur (61.3% (19/31)) was significantly higher than Kageshwori (38.7% (12/31)). The final multivariable logistic regression analysis identified four variables: cattle purchased within 14 days (OR=12.9; CI=2.4-69.5), milk market distance less than two kilometers from the farm (OR=32.7; CI=5.8-186.3), sharing of the bull from other farms for natural insemination (OR=5.7; CI=1.2-26.8), and no vaccination against FMD in the past six months (OR=19.1; CI=2.0-186.2) as significant risk factors for the occurrence of FMD. This study suggests farmers vaccinate their dairy cattle with FMD vaccine as per the vaccination schedule suggested by the veterinarians, practice quarantine measures when new animals are introduced to their farms, practice biosecurity measures in their farms, and do not use bulls from areas where there are ongoing FMD outbreaks.
School Management in Response to Coronavirus Disease 2019
Authors: Wattanayingcharoenchai Suwannachai , Tuangratananon Titiporn , Suphanchaimat Rapeepong
Published: May 2023

The coronavirus disease 2019 (COVID-19) outbreak emerged in Thailand in January 2020 with the situation worsening during March-April 2020. The government decided to lockdown most public places, including schools and daycare nurseries even though the proportion of cases in under 15-year-old was small (about 2.8%). Evidence at the global level did not reach consensus on how to manage school openings properly. The Department of Health of the Ministry of Public Health has delivered school guidelines for the prevention and control of COVID-19. The modelling team of the Department of Disease Control demonstrated that the risk of an infective presenting with a long incubation period (more than seven days) was approximately 12%. This figure reduced to only 1% if a fourteen-day cutoff was applied. The infectivity risk did not depend on the incubation period alone, but greatly relied on the ability of a school to detect a case. With a timely and comprehensive detection rate (close to 100%), a seven-day closure policy yielded almost the same infectivity risk as a fourteen-day closure policy. Policy makers should bring the issues of health, education, and the social impact of children to the table and identify the most appropriate measures to control COVID-19 while ensuring the best quality of life of a child.
Varyasyong Ponolohikal ng Wikang Mandaya sa llang Munisipalidad ng Davao Oriental
Authors: Pasion Raymund , Sandoval Mary Ann
Published: May 2023

Pangunahing layunin ng pag-aaral na ito na tuklasin ang varyasyong ponolohrkal  at ang finggwistikaf na katangiartg makikita sa wikarrg Mandaya na kaiba sa wikeng  Filipino na matatagpuan sa munisipalidad ng Caraga, Manay, Baganga, at Cateel ng Probinsyang Davao Oriental, sa pamamagitan ng paglilikom at pagtatala ng mga terminong kultural na pangkabuhayan-pagsasaka, pangangaso, pangingisda at paghahayupan, batay sa Indigenous Knowledge System and Practices (IKSP) at pagsasälin sa The Swadesh Word List ni Morris Swadesh. Metodong kwalitatibo ang ginamit sa pag-aaral na ito bagama't nahahaluan ng kwantitabo dahil sa minsang paggamit ng bilang at porsyento. Ang paraan o metodong indehinus at deskriptibo ang ginamit mula sa paglilikom hanggang sa pag-aanalisa ng mga datos. Ang mga impormante ay napili sa pamamagitan ng kombinasyong purposive at snow-ball sampling. May varyasyon ang wikang Mandaya sa apat na munisipalidad. Batay sa ponolohikal ay karaniwang nawawala ang tunog na /h/ sa mga salitang ginagamit sa Caraga at Manay kaysa sa mga salitang ginagamit sa Baganga at Cateel. Samantala, nananatili naman ang tunog na /el/ (swa) at ponemang /I-I/ (glide l) sa Caraga at Manay, unti-unti itong nawawaia sa Baganga at hindi na ito naririnig sa mga saiita sa Cateei, Sa pangkalahatan, dahil sa paktor na heograpikal, sikolohikal at sosyolohikal na nagaganap sa wikang Mandaya, hindi maiiwasang magkaroon ng varyasyon sa ponolohikal na aspekto nito.
The Climate Change Awareness Among Senior High School Students in Sorsogon Province, Philippines
Authors: Desabayla Ryan R. , Gueta Nere G.
Published: May 2023

The researchers of this study determined the climate change awareness of senior high school students in Sorsogon Province Division during 2022-2023. The subjects of this study were 412 officially enrolled Grade 11 and Grade 12 Academic and Technical Vocational Livelihood students of Juban National High School and J.P. Laurel High School. The researchers utilized descriptive survey design and used adapted research questionnaires. Moreover, the researchers applied weighted mean and ranking and also used other researchers’ works in explaining the gathered data. Findings revealed that the senior high school students are neutral on climate change mitigation and agree on the effects of climate change. Additionally, internet, television, school, and radio are the major sources of information of senior high school students relative to climate change. The researchers recommended that the senior high school students must continue in educating through the different available sources of information in order to improve their views on climate change which are useful in taking actions in connection with mitigation.
The Role of Deliberate Inclusive Policy on Women Participation in Governance in Kogi State
Authors: Akowe Joel , Usman Salisu Ogbo , Enejoh Omejeh Timothy
Published: May 2023

In addition to meeting the Human Right requirements of the common laws of modern states, involvement of women in governance is very imperative to achieving sustainable peace, democracy, and development. However, this study is worried at the inertia of most countries in the developing world to demonstrate this commitment through convincing deliberate initiatives despite being signatories to several relevant global conventions and protocols. This study therefore examined the activities of Kogi State Government in terms of practical steps taken towards achieving inclusiveness of female gender in the planning and execution of policies in the last six years (2011-2021). While this study relied on both primary and secondary sources for generating the expected facts, Survey design was adopted for drawing the necessary data from the primary source while Systematic Random Sampling Technique was used to generate responses from the sampled population. To analyse the facts of the study, Likert's five-point rating scale was used. The study was able to establish the ecology of the Nigerian democracy and the inherent obstacles to the involvement of women in governance in Kogi State. It recommended more effective strategies for achieving genuine inclusive governance in Kogi State.
MEASURING & MANAGING ORGANIZATIONAL CAPITAL: INNOVATIVENESS CHANGING THE DYNAMICS OF SME’S WORKING IN KHYBER PAKHTUNKHWA
Authors: Zeeshan Ahmad  , Nazia Tabasum
Published: May 2023

Organizational capital plays important role. Organizational capital can be measured through system and program. The purpose of this study is to determine the buffering impact of innovativeness on system and program and entrepreneur’s performance. Small and medium enterprises were the population of this study while sampling size of 384 was selected. Data was cross-sectional and primary data was collected using self-administered scale. For moderation process file was used. Reliability of scale was checked usingalpha values and to test moderating affect hierarchical multiple regression as run with 5000 resample rate. Findings indicate that the relationship between systems and programs and an entrepreneur's performance is moderated by innovativeness. Entrepreneurs can enhance their business performance by bringing innovativeness in their business using novel system and programs.
INVESTIGATING EFFECT OF SOCIAL MEDIA ON MANAGEMENT SCIENCE STUDENTS’ PERFORMANCE
Authors: Muhammad Kamran Afzal
Published: May 2023

Aim of the current study is to find the relationship between social media and management science students’ performance. Survey approach was used and self-administered questionnaire was distributed among students in one public sector and one private sector universities’ students. Total 380 were distributed but 366 complete questionnaires were received back and used in the analysis. Descriptive and inferential statistics are applied using SPSS. To check reliability Cronbach alpha and to test hypotheses correlation and regression analysis are run. It was found that twitter has significant role to improve performance of management students.
EMPIRICAL EVIDENCE ON ROLE OF SELF-EFFICACY UPON COMMITMENT OF TEACHERS IN HIGHER EDUCATION INSTITUTIONS
Authors: Syeda Qurat-ul-ain Zaidi
Published: May 2023

Obviously, the self-efficacy and commitment of instructors in advanced education institutions over the Sothern District Universities of KP have not been discussed nor measured. Of the few reviews concerning this subject, none has focused on individual factors like age, carnal orientation, workload, experience, instruction etc., also the impact they may have on the dedication of HEI's instructors. The inspiration driving current review is to evaluate how much age, sex, workload, experience, education, and self-efficacy influence the commitment of HEI's instructors in the Sothern District Universities of KP. This study has used quantitative way of data collection. This research study has population which consists of all the male and female teachers working in the “Gomal University, D.I.Khan, Khushal Khan Khattak University Karakand University of Science & Technology Bannu, in Khyber Pakhtunkhwa, Pakistan. Sample of 162 was selected as number of questionnaires received responded. The results of this study demonstrated that there was a significant association between job commitment and self-efficacy. There is affirmative association among teacher’s commitment and self-efficacy; it means that when self-efficacy increase, the organizational commitment will also increase. The outcomes of study may help in recruitment process by giving the required standard attributes for selection of new employees, such as behavior, attitudes etc. The study may help the future research by inspiring them to evaluate their current environment and situations, thus questioning the status quo. From this study it is understood that self-efficacy is important and it increases the level of commitment of employee to the job and organization.
Pengaruh Aktivitas E-Commerce Dan Iklan Pada Niat Pembelian Daring: Studi Pada Pengguna Situs Web Layanan Perjalanan
Authors: Sekar Mawar Firdausi Asri , Shely Rizki Hardiana
Published: May 2023

Perkembangan tekonologi yang semakin pesat menyebabkan konsumen begitu mudah melakukan transaksi melalui media elektronik seperti internet. Salah satu bidang usaha yang memanfaatkan kemajuan teknologi ini adalah penyedia jasa layanan perjalanan. Penelitian ini mencoba menganalisis faktor-faktor yang mendorong niat pembelian daring pada pengguna website layanan perjalanan. Terdapat dua variabel independen yang digunakan, yaitu aktivitas e-commerce dan iklan. Sedangkan, niat pembelian daring berperan sebagai variabel dependen dalam penelitian ini. Studi ini menggunakan 200 responden yang dikumpulkan melalui survei daring dengan teknik pengambilan sampel purposive. Hasil temuan menunjukkan bahwa aktivitas e-commerce dan iklan memiliki pengaruh signifikan positif pada niat pembelian daring. Diharapkan temuan ini mampu memberikan masukkan bagi pengelola e-commerce layanan perjalan dalam mengoptimalkan layanannya sehingga pengguna memiliki niat pembelian daring di masa yang akan datang.
The Strategic Training And Development: Integration And Contingency For High Quality
Authors: Halim M
Published: May 2023

This piece of research is referred to as "Strategic Training and Development: Integration and Contingency for High Quality." In the context of training and development (T&D) for employees, the goals of this study were to provide an overview of the process of strategy formulation, an overview of the process of strategy implementation, an account of the process of strategy evaluation, and an overview of how to measure the success of the implementation. The qualitative research approaches were applied in this case study. Interviews, observations, and documentation were the three methods that were used to collect data. The key sources of information consisted of six different supervisors and staff. The data were analyzed using analyses performed both before and during the fieldwork. The validity test was conducted by combining the credibility test with the transferability test. According to the findings of this study, the process of formulating a strategy in T&D is characterized by the following: the relationship between strategic objectives and the organization's mission; the needs assessments conducted by the department; guest opinions; government regulation or policy action; and financial and budgetary concerns. The description of the implementation strategy in T&D was a cross-hierarchy task that required the performance of a series of processes, including program development, budgeting, and the procedure to follow the organization's strategies that had been designed to achieve synergy. The T&D strategy detailed an evaluation procedure that included evaluating the field performance of the company, customer input, and revenue from the company's products and services. The T&D approach is stated as a success indication of increased revenue, satisfied customers, and a reduction in negative feedback.
La resolución de problemas matemáticos en estudiantes de educación primaria
Authors: Clavo Núñez Patricia Janet , Chanta Chanamé Luis Fernando , Gonzales Soto Víctor Augusto
Published: May 2023

Una competencia imprescindible para el aprendizaje del estudiante es la resolución de problemas matemáticos; no obstante, durante la escolaridad, los estudiantes presentan dificultades en su desarrollo. El objetivo de la investigación es analizar diversas investigaciones respecto a cómo desde la educación primaria se ha desarrollado la competencia de resolución de problemas matemáticos. Para ello, se utilizó una investigación cualitativa, método hermenéutico y de tipo revisión bibliográfica. Se seleccionaron y analizaron 16 artículos científicos relacionados con la temática desarrollada de artículos indexados a las bases de datos de Scopus y ScienceDirect, hallándose como resultado que el uso de modelos y estrategias didácticas ayuda a desarrollar esta competencia en estudiantes del nivel primario, sobre todo, presentando las situaciones problemáticas de acorde a las particularidades del estudiante y su contexto. Se concluye que es posible desarrollar la resolución de problemas en educandos del nivel primario fomentando situaciones retadoras y propias de su entorno social, en espacios lúdicos y motivadores; además, mediante la atención a factores que pueden dificultar tener un espacio de trabajo sano y saludable.
Implementasi Kebijakan Kurikulum pada Pendidikan Prodi Teknik Mesin Kapal Perang di Akademi TNI Angkatan Laut
Authors: Rokhmawan Sonnie , Susilowati Dyah , Hartanto Yusa Adi , Kurniazain Adiyus
Published: May 2023

Education is the foundation for character formation in the process of human resource development. Through education, we shape human beings with great academic, moral, mental, personality, physical, and spiritual to realize and support national development. Military education in AAL (Indonesian Navy Academy) aims to educate and equip the cadets to be naval officer of Sapta Marga who has a physical kesamaptaan, marine professionalism with knowledge and skills in the field of logistics management of the Navy and mechanical engineering of warships that can support the task of the Department of Machinery In preparing KRI as Assistant Head of Machine Division, and other positions are level at KRI and able to develop personally as cadre leader of Navy. This study aims to determine the extent to which Implementation of Chief Policy No. Kep 492 / IV / 2013 which contains the curriculum of the Naval Academy of Naval Engineering. This research uses Qualitative Descriptive method and using Van Meter and Van Horn theory as a benchmark to determine the factors inhibiting and supporting the implementation of educational curriculum in the Department of Mechanical Engineering Warship. This research can be a suggestion and improvement in educational programs in the following academic year.

Pendidikan merupakan landasan pembentukan karakter dalam proses pembangunan sumber daya manusia untuk mendapatkan manusia dengan kualitas akademik, moral, mental, pribadi, jasmani dan rohani yang baik. Pendidikan berperan besar dalam mewujudkan pembangunan dan tujuan nasional. Dengan demikian, pendidikan kemiliteran di Akademi Angkatan Laut (AAL) bertujuan untuk mendidik dan membekali taruna menjadi Perwira Angkatan Laut Sapta Marga yang memiliki kesamaptaan fisik, profesionalisme kelautan dengan pengetahuan dan keterampilan di bidang pengelolaan logistik TNI AL dan teknik mesin kapal perang. Pengetahuan dan keterampilan tersebut nantinya diharapkan  dapat menunjang tugas dari para perwira. Sementara itu, Departemen Permesinan mempersiapkan Pembantu Kepala Divisi Mesin, dan jabatan lainnya setingkat di Kapal Republik Indonesia (KRI) dan mengembangkan Kader Kader TNI Angkatan Laut. Penelitian ini bertujuan untuk mengetahui Implementasi Kebijakan Kepala No. Kep 492/IV/2013 yang memuat kurikulum Akademi Angkatan Laut Teknik Perkapalan. Penelitian ini menggunakan metode Deskriptif Kualitatif dan menggunakan teori Van Meter dan Van Horn sebagai tolak ukur untuk mengetahui faktor-faktor penghambat dan pendukung implementasi kurikulum pendidikan di Jurusan Teknik Mesin Kapal Perang. Hasil dari penelitian ini diharapkan dapat menjadi masukan dan perbaikan program pendidikan pada tahun ajaran berikutnya.
Pengembangan Evaluasi Paket Instruksi Renang Umum Korps Marinir AAL
Authors: Saputro Bambang Eko , Sumarwoto Sumarwoto , Salim Agus , Santoso Budi
Published: May 2023

This study examines the swimming instruction package, focusing on the essential factors to improve the quality of the Marine Corps Cadets General Swimming Instruction Package to facilitate the understanding of AAL Marine Corps Cadets in completing their final assignment. The sub-aspects being investigated included aspects of the feasibility of the contents of the Public Swimming PI material, the language aspects of the Public Swimming instruction packs, material presentation of Public Swimming instruction packs, and aspects of graphic design of the Public Swimming instruction. Our research design contained steps of analysis, design, evaluation, and revision, while the data analysis was carried out using descriptive qualitative. Based on all the analysis results, the average score for each aspect is a) the design attains an average value of 95 percent; b) the content attains an average value of 94 percent; c) individual exercise attains an average value of 94 percent; d) small group exercise attained an average value of 91.8 percent; and e) field trial attains average value of 90.8 percent. Thus, the total average score is 93.12 percent.

Penelitian ini mengkaji paket instruksi dengan memperhatikan faktor-faktor yang perlu diperbaiki untuk meningkatkan kualitas Paket Instruksi (PI) renang umum taruna Korps Marinir agar dapat membantu memudahkan pemahaman para taruna dalam menyelesaikan tugas akhir. Adapun sub aspek yang diteliti meliputi aspek kelayakan isi materi, aspek kebahasaan, aspek penyajian dan aspek desain grafis dari PI renang umum. Proses penelitian ini menerapkan design research meliputi langkah-langkah analisis, perancangan, evaluasi, dan revisi, sedangkan teknik analisis data dilakukan menggunakan deskriptif kualitatif. Berdasarkan seluruh uji coba yang penulis laksanakan maka nilai rata- rata hasil dari uji coba  tersebut: a) uji coba desain 95 persen; b) uji coba isi 94 persen; c)uji coba perorangan 94 persen; d) uji coba kelompok kecil 91,8 persen; dan e) uji coba lapangan 90,8 persen. Sehingga nilai rata-rata keseluruhan adalah 93,12 persen.
Implementasi Pembelajaran dengan Pendekatan Inkuiri Terbimbing untuk Peningkatan Hasil Belajar Taruna AAL
Authors: Khalid Khairun , Aisyah Nur , Soemantri Asep Iwa , Wandiru Mangutu
Published: May 2023

Guided inquiry is a learning approach in which the teacher provides broad guidance or instructions to students, and the teacher makes most of the planning. Students carry out a series of activities with the guidance of the teacher. Thus, it right ahead means that students are involved with scientific questions. They formulate hypotheses, experiments, data analysis interpretation, and results communication. This research aims to describe the teacher's ability to manage learning activity using the guided inquiry approach. Moreover, the results of the study showed that learning with a guided inquiry approach can improve the learning outcomes of cadets, especially for the subjects held in the laboratory (practicum).

Inkuiri terbimbing adalah suatu pendekatan pembelajaran yang dalam pelaksanaannya, guru menyediakan bimbingan atau petunjuk cukup luas kepada siswa, serta sebagian besar perencanaannya dibuat oleh guru. Serangkaian kegiatan tersebut dilakukan oleh siswa dengan bimbingan guru. Dengan demikian secara langsung bahwa siswa terlibat dengan peristiwa dan pertanyaan ilmiah. Siswa merumuskan hipotesis, eksperimen, siswa menganalisa dan menginterpretasikan data, dan mengkomunikasikan hasilnya. Tujuan penulisan ini adalah mendiskripsikan kemampuan guru dalam mengelola pembelajaran dengan menggunakaan pendekatan inkuiri terbimbing. Hasil dari penelitian menunjukkan bahwa pembelajaran dengan pendekatan inkuiri terbimbing dapat meningkatkan hasil belajar taruna, khususnya pada mata kuliah yang dilaksanakan di labortorium (praktikum).
Early Detection of Cancer using Machine Learning (ML) Techniques
Authors: Mahesh T R  , Vinoth Kumar
Published: May 2023

Early detection of cancer sickness leads to rapid treatment, reducing the risk of morbidity and mortality. The diagnosis of oral cancer continues to be a challenge for dental careers, particularly in the location, evaluation, and review of early-stage oral disease. Due to the lack of optimal analysis using conventional methods, oral cancer is identified and grouped using AI at an early stage. AI techniques are used to show the movement and treatment of dangerous locations and may accurately predict future disease effects. AI techniques are used to show the movement and treatment of dangerous locations and may accurately predict future disease effects. A combination of expert AI and highlight determination calculations produces improved results in the early detection and forecast of oral cancer. The main goal and commitment of this audit study is to summarize the use of AI technologies for accurate early prediction of oral malignant development.
The Development of the Concept of Consolidation Centers in Using the Sharing Economy in Postal Services / Logistics
Authors: Milutinović Jelena , Grgurović Biljana , Veličković Stevan , Veličković Stevan
Published: May 2023

Switching the business philosophy from “having” to “sharing/using” is especially important when it comes to information technologies, where there is a direct connection between interested parties which, at the same time, can be potential providers and users of services. This principle has found its place in various areas (transportation, services, education, entrepreneurship, real estate, commerce, finance, information technologies). Through its application, companies gain the possibility to demonstrate their potential for contributing to the community, reducing environmental impact, and staying profitable. As the interest in goods in urban areas has been on the rise in the whole world, the necessity for measures which would lower the negative effects of freight traffic is inevitable. In that context, in this paper, we will consider the possibilities of applying different models of the sharing economy concept in postal services, as well as the factors which affect the application and implementation of this concept.
Preconditions and requirements for the development and quality assurance of logistics services
Authors: Kiso Fadila , Karičić Samira
Published: May 2023

All processes in the production and distribution of material goods, which include material and interactive information flows, are united by the term “Logistics” and are realized within the logistics processes. Logistics processes hide large technological and economic reserves that need to be identified, located and used. At the EU level, a new philosophy of realization of quality logistics processes has been created in the past decades, and it is increasingly including the environmental aspect by introducing the term Green Logistics, which highlights the demand for a healthy environment. The level of logistics process technology is still far below the level of development of material production technology, which is the main reason for giving strategic importance to the rationalization and optimization of logistics processes at the global level in order at reducing the costs of all participants in the implementation of the process, and especially in the direction of raising the quality of services and meeting the increasingly stringent requirements of service users.
Possibilities of kinetic imaging in the observation of bird embryos in non- invasive ecotoxicological studies
Authors: Strobel Lilla , Gyánó Marcell
Published: May 2023

In order to make ecotoxicological studies using bird embryos simpler and more cost effective, kinetic imaging, already proven in human medicine, was tested. In the study, a total of 8 still-living embryos were examined non-invasively with low-intensity (50 keV) X-rays. During the measurement, we tried to assess how the embryos react if they are not stored at the temperature of 38 °C required for hatching for 1 hour.
Penerapan Metode Omnibus Law dalam Pembentukan Undang-Undang Nomor 11 Tahun 2020 Tentang Cipta Kerja
Authors: Kurniyasih Fajar , Setyorini Ika
Published: May 2023

The application of an Omnibus Law method first full-length time is used in Indonesia in the formation of the Law No. 11 Year 2020 about Cipta Kerja. This certainly need to examined will the adoption of an Omnibus Law method in the formation of the Law Cipta Kerja in accordance with the procedures and the principles for the formation of legislations in Indonesia. This study using qualitiative methodology through approach normative juridical that have been analyzed a sort of descriptive set with conducted research on the application of an Omnibus Law method in the of the Law Cipta Kerja and legislations which are related. In this context discusses how the law in the formation of an omnibus legislation, in Indonesia the application of an Omnibus Law method in the of  the Law Cipta Kerja in the formation and the discourse.Through this research, the results obtained that the Omnibus Law Method has been substantively carried out in Indonesia in the formation of several laws and regulations and the position of Omnibus Law is as a method. An Omnibus Law has not been regulated in of Law No. 12 Year 2011 that has been converted in of Law No. 15 Year 2019 at about rule the formation of legislation, so there will be a different on a number of clauses in the preparation of the Law Cipta Kerja. This then creates a discourse in its application which has implications for the quality of The Law Cipta Kerja.
LEGIO I MINERVIA AND LEGIO XI CLAUDIA STAMPS ON BUILDING CERAMICS FROM SECTOR XII AT NOVAE — A CONTRIBUTION TO STUDIES OF MILITARY BUILDING MATERIAL PRODUCTION CENTRES
Authors: Duch Michał
Published: May 2023

The paper analyses 29 specimens of stamps of legio I Minervia and legio XI Claudia, discovered in Sector XII at Novae. Based on the artefacts, the author revisits the theses concerning so-called production centres of building ceramics. Furthermore, the author suggests a reinterpreted reading of TRA’EX and supplements the typology of such relics from Novae.
2021–2022 Drug Updates: Investigational Therapeutics in the Pipeline
Authors: C. Moore, PharmD, BCPS, BCOP, DPLA, FCCP Donald
Published: May 2023

During JADPRO Live 2022, Donald C. Moore, PharmD, BCPS, BCOP, DPLA, FCCP, discussed investigational therapeutic agents in the drug development pipeline. Dr. Moore highlighted agents that represent either a new drug class, a novel mechanism of action, a rethinking of how to approach treating a disease, or those that have recently received FDA Breakthrough Designation status that advanced practitioners should be aware of.
Updating the Targeted Therapy Paradigm for Patients With Metastatic NSCLC
Authors: Florez, MD Narjust , McDonald, NP Stephanie
Published: May 2023

The treatment paradigm for metastatic non–small cell lung cancer has changed significantly since the advent of targeted therapy. During JADPRO Live 2022, presenters focused on important updates to clinical practice guidelines, data from recent clinical trials of biomarkers and their respective targeted therapies, and best practices for monitoring and managing side effects associated with targeted therapies for metastatic non–small cell lung cancer.
Novel Treatments for Patients With Relapsed/Refractory Multiple Myeloma
Authors: Rodriguez, MD Cesar , Catamero, ANP-BC, OCN, CCRC Donna
Published: May 2023

Therapeutic options for patients with multiple myeloma have multiplied in the past decade. However, multiple myeloma remains an incurable disease, and relapsed/refractory myeloma is characterized by genetic and cytogenetic alterations that drive resistance and result in progressively shorter durations of remission to each subsequent therapy. At JADPRO Live 2022, presenters discussed the multifactorial process for choosing the right therapy for a particular patient and strategies to manage unique treatment complications associated with novel treatment modalities used for patients with relapsed/refractory multiple myeloma.
Uncovering and Addressing Implicit Bias in Oncology
Authors: DiMarco, PharmD, BCPS, BCOP Rose , S. Guinigundo, MSN, RN, CNP, ANP-BC Andrew , Valdueza, MSN, AGNP-C Caressa
Published: May 2023

Implicit bias affects patient care every day, and not just in oncology. It impacts decision-making in already vulnerable populations such as the historically marginalized racial and ethnic groups, the LGBTQI+ population, patients with disabilities, and patients with low socioeconomic status or low health literacy. At JADPRO Live 2022 in Aurora, Colorado, panelists took a deep look at implicit bias and its impact on health inequities. They then discussed best practices for increasing equity and representation in clinical trials, ways to facilitate equitable communication and interactions with patients, and finally shared steps that advanced practitioners can take to minimize the impact of implicit bias.
Managing the Patient With Multiple Primary Tumors
Authors: Chitwood, DNP, APRN, FNP, AGACNP Holly , Carey, MSN, APRN, FNP Tamara
Published: May 2023

Multiple primaries are defined as more than one synchronous or metachronous cancer in the same individual. They can pose challenges to clinicians, as the goal is to find an anticancer therapy strategy that covers both cancer types without increased toxicity or drug interactions, and does not negatively impact a patient’s overall outcome. At JADPRO Live 2022, presenters tackled this complicated topic by reviewing diagnostic criteria, epidemiology, and risk factors, demonstrating the prioritization of treatment, and discussing the role of the advanced practitioner in collaborative, interdisciplinary management of the patient with multiple primary tumors.
The Mycobacterium ulcerans toxin mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane to drive skin necrosis
Authors: Hsieh Louise Tzung-Harn , Hall Belinda S , Newcombe Jane , Mendum Tom A , Varela Sonia Santana , Umrania Yagnesh , Deery Michael J , Shi Wei Q , Diaz-Delgado Josué , Salguero Francisco J , Simmonds Rachel E
Published: May 2023

The drivers of tissue necrosis in Mycobacterium ulcerans infection (Buruli ulcer disease) have historically been ascribed solely to the directly cytotoxic action of the diffusible exotoxin, mycolactone. However, its role in the clinically evident vascular component of disease aetiology remains poorly explained. We have now dissected mycolactone’s effects on human primary vascular endothelial cells in vitro. We show that mycolactone-induced changes in endothelial morphology, adhesion, migration, and permeability are dependent on its action at the Sec61 translocon. Unbiased quantitative proteomics identified a profound effect on proteoglycans, driven by rapid loss of type II transmembrane proteins of the Golgi, including enzymes required for glycosaminoglycan (GAG) synthesis, combined with a reduction in the core proteins themselves. Loss of the glycocalyx is likely to be of particular mechanistic importance, since knockdown of galactosyltransferase II (beta-1,3-galactotransferase 6; B3GALT6), the GAG linker-building enzyme, phenocopied the permeability and phenotypic changes induced by mycolactone. Additionally, mycolactone depleted many secreted basement membrane components and microvascular basement membranes were disrupted in vivo during M. ulcerans infection in the mouse model. Remarkably, exogenous addition of laminin-511 reduced endothelial cell rounding, restored cell attachment and reversed the defective migration caused by mycolactone. Hence supplementing mycolactone-depleted extracellular matrix may be a future therapeutic avenue, to improve wound healing rates.
Mycolactone causes catastrophic Sec61-dependent loss of the endothelial glycocalyx and basement membrane: a new indirect mechanism driving tissue necrosis in Mycobacterium ulcerans infection
Authors: Hsieh Louise Tzung-Harn , Hall Belinda S. , Newcombe Jane , Mendum Tom A. , Umrania Yagnesh , Deery Michael J. , Shi Wei Q. , Salguero Francisco J. , Simmonds Rachel E
Published: May 2023

The drivers of tissue necrosis in
Mycobacterium ulcerans
infection (Buruli ulcer disease) have historically been ascribed solely to the directly cytotoxic action of the diffusible exotoxin, mycolactone. However, its role in the clinically-evident vascular component of disease aetiology remains poorly explained. We have now dissected mycolactone’s effects on primary vascular endothelial cells
in vitro
and
in vivo
. We show that mycolactone-induced changes in endothelial morphology, adhesion, migration, and permeability are dependent on its action at the Sec61 translocon. Unbiased quantitative proteomics identified a profound effect on proteoglycans, driven by rapid loss of type II transmembrane proteins of the Golgi, including enzymes required for glycosaminoglycan (GAG) synthesis, combined with a reduction in the core proteins themselves. Loss of the glycocalyx is likely to be of particular mechanistic importance, since knockdown of galactosyltransferase II (beta-1,3-galactotransferase 6; B3Galt6), the GAG linker-building enzyme, phenocopied the permeability and phenotypic changes induced by mycolactone. Additionally, mycolactone depleted many secreted basement membrane components and microvascular basement membranes were disrupted
in vivo
. Remarkably, exogenous addition of laminin-511 reduced endothelial cell rounding, restored cell attachment and reversed the defective migration caused by mycolactone. Hence supplementing mycolactone-depleted extracellular matrix may be a future therapeutic avenue, to improve wound healing rates.
An overview of the osseous palmar sesamoid in Anura, with the particular case of someRhinellaspecies
Authors: Manzano Adriana , Abdala Virginia
Published: May 2023

Background

Sesamoids are generally regarded as structures that are not part of the tetrapod body plan. The presence of a palmar sesamoid is assumed to serve as a distribution point for the forces of the flexor digitorum communis muscle to the flexor tendons of the digits, which are embedded in the flexor plate. It has been considered that the palmar sesamoid is present in most anuran groups, and it has been suggested that it acts by inhibiting the closing of the palm, preventing grasping. Typical arboreal anuran groups lack a palmar sesamoid and flexor plate, a pattern shared with other tetrapod groups, which can retain a reduced sesamoid and flexor plate. We focus on the anatomical structure of theRhinellagroup, which includes species that present an osseous palmar sesamoid and climb bushes or trees to avoid depredation or escape dangerous situations, and can exhibit scansorial and arboreal behaviors. We also add data on the bony sesamoids of 170 anuran species to study the anatomy and evolution of the osseous palmar sesamoid within this amphibian group. Our objective is to bring an overview of the osseous palmar sesamoid in anurans, unveiling the relationship between this element of the manus, its phylogeny, and the anuran habitat use.

Methods

Skeletal whole-mount specimens ofRhinellawere cleared and double-dyed to describe the sesamoid anatomy and related tissues. We review and describe the palmar sesamoid of 170 anuran species from CT images downloaded from Morphosource.org, representing almost all Anuran families. We performed an standard ancestral state reconstruction by optimizing two selected characters (osseous palmar sesamoid presence, distal carpal palmar surface) along with the habitat use of the sampled taxa, using parsimony with Mesquite 3.7.

Results

Our primary finding is that sesamoid optimization in the anuran phylogeny revealed that its presence is associated with certain clades and not as widespread as previously anticipated. Additionally, we will also be delving into other important outcomes of our study that are relevant to those working in the field of anuran sesamoids. The osseous palmar sesamoid is present in the clade Bufonidae-Dendrobatidae-Leptodactylidae-Brachicephalidae that we named as PS clade, and also in the archeobatrachian pelobatoidLeptobranchium, all strongly terrestrial and burrowing species, though with exceptions. The osseous palmar sesamoid is always present in Bufonidae, but varies in form and size, depending on the mode that they use their manus, such as in theRhinella margaritiferawhich has a cylindrical one and also grasping abilities that involve closing the manus. The scattered presence of the bony palmar sesamoid among anuran clades raises the question whether this sesamoid can be present with a different tissular composition in other groups.
Identification and functional analysis of non-coding regulatory small RNA FenSr3 in Bacillus amyloliquefaciens LPB-18
Authors: Yang Panping , Geng Chengxin , Zhu Shaohui , Zhou Zhen , Bilal Muhammad , Gu Chengyuan , Xu Hai , Ji Linchun , Xiao Benchang , Wang Jingye , Qian Zhoujie , Zhao Li , Zhao Yuping , Lu Hedong
Published: May 2023

Bacillus amyloliquefaciens is an interesting microbe in the food processing and manufacturing industries. Non-coding small RNAs (sRNAs) have been shown to play a crucial role in the physiology and metabolism of bacteria by post-transcriptionally regulating gene expression. This study investigated the function of novel sRNA FenSr3 by constructing fenSr3 deficient strain and complementary strains in B. amyloliquefaciens LPB-18 , which were named LPN-18N and LPB-18P, respectively. The result showed significant differences in fengycin yield between strain LPB -18N and LPB-18P. The production of fengycin was significantly enhanced in B. amyloliquefaciens LPB-18N, compared with that of the strain LPB-18 from 190.908 mg/L to 327.598 mg/L. Moreover, the production of fengycin decreased from 190.464 mg/L to 38.6 mg/L in B . amyloliquefaciens LPB-18P. A comparative transcriptome sequencing was carried out to better understand the complex regulatory mechanism. Transcription analysis revealed that 1037 genes were differentially expressed between B. amyloliquefaciens LPB-18 and B. amyloliquefaciens LPB-18N, including the key regulatory genes in fatty acid, amino acid biosynthesis, and central carbon metabolism, which could provide sufficient quantities of building precursors for fengycin biosynthesis. The biofilm formation and sporulation was also enhanced in the strain LPB-18N, which indicates that FenSr3 could play a vital role in stress resistance and promotes survival in B. amyloliquefaciens. Some sRNAs involved in stress response have been identified in the literature, but their regulatory roles in fengycin production remain unclear. The study will contribute a novel perspective to the regulation mechanism of biosynthesis and the optimization of key metabolites of B. amyloliquefaciens.
Responses of soil organic carbon cycle to land degradation by isotopically tracing in a typical karst area, southwest China
Authors: Han Ruiyin , Zhang Qian , Xu Zhifang
Published: May 2023

Background

The loss of soil organic carbon (SOC) under land degradation threatens crop production and reduces soil fertility and stability, which is more reflected in eco-sensitive environments. However, fewer studies simultaneously compared SOC variations and δ13CSOC compositions under diverse land uses, especially in karst areas.

Methods

Soil profiles from two agricultural lands and a secondary forest land were selected to analyze SOC contents and their stable isotope composition (δ13CSOC) in a typical karst area located in southwest China to understand the response of the SOC cycle to land degradation. Moreover, the relationships between SOC contents and mean weight diameter (MWD) and soil erodibility (K) factor were comprehensively analyzed for assessing the response of SOC to soil degradation risk.

Results

The mean SOC content was found to be the lowest in abandoned cropland (6.91 g/kg), followed by secondary forest land (9.31 g/kg) and grazing shrubland (34.80 g/kg), respectively. Meanwhile, the δ13CSOC values exhibited the following trend: secondary forest land (mean: −23.79‰) ≈abandoned cropland (mean: −23.76‰) >shrubland (mean: −25.33‰). The isotopic tracing results suggested that plant litter was the main contributor to SOC in the secondary forest land. Whereas abundant nitrogen from goat feces enhanced plant productivity and resulted in additional accumulation of SOC in the grazing shrubland. Conversely, long-term cultivation led to the depletion of SOC sequestration by the loss of calcium. In surface soils, the fractionation of δ13CSOC were considerably affected by the decomposition of SOC by soil microorganisms and covered vegetation rather than agricultural influences.

Conclusions

The findings indicate that the cycling of SOC and soil stability in the calcareous soil of southwest China are largely regulated by different land uses and the presence of vegetation cover. The depletion of SOC and soil physical degradation pose significant challenges for abandoned cropland, particularly in the karst area, where land degradation is inevitable. Nevertheless, moderate grazing enhances SOC levels, which is beneficial to the land fertility maintenance in the karst region. Therefore, more emphasis should be placed on the cultivation methods and management strategies for abandoned cropland in the karst area.