bluuebunny/crossref_metadata_2025 huggingface dataset:
Cellular Automata Modeling as a Tool in Corrosion Management
Authors: Reinoso-Burrows Juan C. , Toro Norman , Cortés-Carmona Marcelo , Pineda Fabiola , Henriquez Mauro , Galleguillos Madrid Felipe M.
Published: September 2023

Cellular automata models have emerged as a valuable tool in corrosion management. This manuscript provides an overview of the application of cellular automata models in corrosion research, highlighting their benefits and contributions to understanding the complex nature of corrosion processes. Cellular automata models offer a computational approach to simulating corrosion behavior at the microscale, capturing the intricate interactions between electrochemical reactions, material properties, and environmental factors and generating a new vision of predictive maintenance. It reviews the key features of cellular automata, such as the grid-based representation of the material surface, the definition of state variables, and the rules governing cell-state transitions. The ability to model local interactions and emergent global behavior makes cellular automata particularly suitable for simulating corrosion processes. Finally, cellular automata models offer a powerful and versatile approach to studying corrosion processes, expanding models that can continue to enhance our understanding of corrosion and contribute to the development of effective corrosion prevention and control strategies.
Analysis of Weld Lines in Micro-Injection Molding
Authors: Liparoti Sara , De Piano Giorgia , Salomone Rita , Pantani Roberto
Published: September 2023

Micro-injection molding (µIM) is a widespread process for the production of plastic parts with at least one dimension, or feature, in the microscale (conventionally below 500 µm). Despite injection molding being recognized as a robust process for obtaining parts with high geometry accuracy, one last occurrence remains a challenge in micro-injection molding, especially when junctions are present on the parts: the so-called weld lines. As weld lines are crucial in determining mechanical part performances, it is mandatory to clarify weld line position and characteristics, especially at the industrial scale during mold design, to limit failure causes. Many works deal with weld lines and their dependence on processing parameters for conventional injection molding, but only a few works focus on the weld line in µIM. This work examines the influence of mold temperature on the weld line position and strength by both experimental and simulation approaches in µIM. At mold temperatures below 100 °C, only short shots were obtained in the chosen cavity. At increased mold temperatures, weld lines show up to a 40% decrease in the whole length, and the overall tensile modulus doubles. This finding can be attributed to the reduction of the orientation at the weld line location favored by high mold temperatures. Moldflow simulations consistently reproduce the main features of the process, weld line position and length. The discrepancy between experimental and simulated results was attributed to the fact that crystallization in flow conditions was not accounted for in the model.
Life Cycle Assessment of Raw and Fe-Modified Biochars: Contributing to Circular Economy
Authors: Gallego-Ramírez Carolina , Chica Edwin , Rubio-Clemente Ainhoa
Published: September 2023

Biochar is a carbonaceous material, which can be decorated with metals, that has been garnering attention to be used in the treatment of water due to its contribution to waste management and circular economy. This study presents the life cycle assessment (LCA) regarding the generation of Pinus patula raw biochar and its modification with iron (Fe-modified biochar). SimaPro 9.3.0.3 software was used to simulate the environmental impacts of both carbonaceous materials. The potential environmental effects obtained from the production of Pinus patula raw biochar were mainly ascribed to the source of energy utilized during this process. The potential impacts demonstrated that the generation of gases and polycyclic aromatic hydrocarbons are the main concern. In the case of Fe-modified biochar, the potential environmental effects differed only in the stage of the biomass modification with the metal. These effects are associated with the extraction of Fe and the generation of wastewater. These findings provide an insight into the environmental effects linked to the production of raw and Fe-modified biochar. However, further LCA research should be performed concerning other materials and compounds than can be generated during the biomass thermochemical conversion.
The Role of Lithium-Ion Batteries in the Growing Trend of Electric Vehicles
Authors: Ralls Alessandro M. , Leong Kaitlin , Clayton Jennifer , Fuelling Phillip , Mercer Cody , Navarro Vincent , Menezes Pradeep L.
Published: September 2023

Within the automotive field, there has been an increasing amount of global attention toward the usability of combustion-independent electric vehicles (EVs). Once considered an overly ambitious and costly venture, the popularity and practicality of EVs have been gradually increasing due to the usage of Li-ion batteries (LIBs). Although the topic of LIBs has been extensively covered, there has not yet been a review that covers the current advancements of LIBs from economic, industrial, and technical perspectives. Specific overviews on aspects such as international policy changes, the implementation of cloud-based systems with deep learning capabilities, and advanced EV-based LIB electrode materials are discussed. Recommendations to address the current challenges in the EV-based LIB market are discussed. Furthermore, suggestions for short-term, medium-term, and long-term goals that the LIB-EV industry should follow are provided to ensure its success in the near future. Based on this literature review, it can be suggested that EV-based LIBs will continue to be a hot topic in the years to come and that there is still a large amount of room for their overall advancement.
Effects of Thermal-Strain-Induced Atomic Intermixing on the Interfacial and Photoluminescence Properties of InGaAs/AlGaAs Multiple Quantum Wells
Authors: Yang Zhi , Zhang Shuai , Ma Shufang , Shi Yu , Liu Qingming , Hao Xiaodong , Shang Lin , Han Bin , Qiu Bocang , Xu Bingshe
Published: September 2023

Quantum-well intermixing (QWI) technology is commonly considered as an effective methodology to tune the post-growth bandgap energy of semiconductor composites for electronic applications in diode lasers and photonic integrated devices. However, the specific influencing mechanism of the interfacial strain introduced by the dielectric-layer-modulated multiple quantum well (MQW) structures on the photoluminescence (PL) property and interfacial quality still remains unclear. Therefore, in the present study, different thicknesses of SiO2-layer samples were coated and then annealed under high temperature to introduce interfacial strain and enhance atomic interdiffusion at the barrier–well interfaces. Based on the optical and microstructural experimental test results, it was found that the SiO2 capping thickness played a positive role in driving the blueshift of the PL peak, leading to a widely tunable PL emission for post-growth MQWs. After annealing, the blueshift in the InGaAs/AlGaAs MQW structures was found to increase with increased thickness of the SiO2 layer, and the largest blueshift of 30 eV was obtained in the sample covered with a 600 nm thick SiO2 layer that was annealed at 850 °C for 180 s. Additionally, significant well-width fluctuations were observed at the MQW interface after intermixing, due to the interfacial strain introduced by the thermal mismatch between SiO2 and GaAs, which enhanced the inhomogeneous diffusion rate of interfacial atoms. Thus, it can be demonstrated that the introduction of appropriate interfacial strain in the QWI process is of great significance for the regulation of MQW band structure as well as the control of interfacial quality.
Data Transformation in the Predict-Then-Optimize Framework: Enhancing Decision Making under Uncertainty
Authors: Tian Xuecheng , Guan Yanxia , Wang Shuaian
Published: September 2023

Decision making under uncertainty is pivotal in real-world scenarios, such as selecting the shortest transportation route amidst variable traffic conditions or choosing the best investment portfolio during market fluctuations. In today’s big data age, while the predict-then-optimize framework has become a standard method for tackling uncertain optimization challenges using machine learning tools, many prediction models overlook data intricacies such as outliers and heteroskedasticity. These oversights can degrade decision-making quality. To enhance predictive accuracy and consequent decision-making quality, we introduce a data transformation technique into the predict-then-optimize framework. Our approach transforms target values in linear regression, decision tree, and random forest models using a power function, aiming to boost their predictive prowess and, in turn, drive better decisions. Empirical validation on several datasets reveals marked improvements in decision tree and random forest models. In contrast, the benefits of linear regression are nuanced. Thus, while data transformation can bolster the predict-then-optimize framework, its efficacy is model-dependent. This research underscores the potential of tailoring transformation techniques for specific models to foster reliable and robust decision-making under uncertainty.
Homogenization of Smoluchowski Equations in Thin Heterogeneous Porous Domains
Authors: Noucheun Reine Gladys , Woukeng Jean Louis
Published: September 2023

In a thin heterogeneous porous layer, we carry out a multiscale analysis of Smoluchowski’s discrete diffusion–coagulation equations describing the evolution density of diffusing particles that are subject to coagulation in pairs. Assuming that the thin heterogeneous layer is made up of microstructures that are uniformly distributed inside, we obtain in the limit an upscaled model in the lower space dimension. We also prove a corrector-type result very useful in numerical computations. In view of the thin structure of the domain, we appeal to a concept of two-scale convergence adapted to thin heterogeneous media to achieve our goal.
A Retrospective Analysis of the Association of Neutrophil–Lymphocyte Ratio (NLR) with Anemia in the Saudi Population
Authors: Alshuweishi Yazeed , Alfaifi Mohammed , Almoghrabi Yousef , Al-Sheikh Yazeed A. , Alfhili Mohammad A.
Published: September 2023

Background: The link between inflammation and anemia is well established but fluctuations in the emerging inflammatory index, neutrophil–lymphocyte ratio (NLR), in anemic subjects remain ambiguous. The purpose of this study is to address the prevailing knowledge gaps regarding the association of NLR with anemia in the Saudi population. Methods: Laboratory results of NLR, C-reactive protein (CRP), and hemoglobin for 14,261 subjects were obtained from Al Borg Diagnostics and retrospectively analyzed. Means, risk measures, and the diagnostic performance of NLR for anemia were examined in age- and gender-wise comparisons. Results: NLR was significantly elevated in anemic individuals and those with high NLR had a significantly lower Hb concentration. Moreover, elevated NLR was more prevalent in anemic subjects (PR: 1.87, 95% CI: 1.46–2.40, p < 0.0001) and carried a greater risk for the condition (OR: 1.91, 95% CI: 1.47–2.48, p < 0.0001) as did CRP. These observations demonstrated distinct age- and gender-specific patterns. However, both parameters were of no value in the diagnosis of anemia as seen from receiver operating characteristic curves. Conclusions: Altogether, these findings indicate that elevated NLR is associated with anemia, which suggests its usefulness for monitoring rather than diagnosing anemia associated with inflammation in Saudi subjects. Further examination of this association in longitudinal studies is needed.
Separation Techniques and Circular Economy
Authors: Cao Da-Qi
Published: September 2023

Efficient separation techniques play an important role in the process of resource recovery, and these techniques include physical, chemical, physicochemical, and/or biological methods that are selected for their low cost and low energy consumption and for being free of secondary pollution [...]
Local Ratcheting at the Notch Region of Non-Press-Fitted and Press-Fitted Al 7075-T6 Samples Undergoing Asymmetric Stress Cycles
Authors: Hatami F. , Varvani-Farahani A.
Published: September 2023

The present study evaluated the ratcheting response of notched and press-fitted Al 7075-T6 specimens under stress-controlled asymmetric cycles. The degree of the interference fit (DIF) directly influenced the magnitude and the rate of progressive plastic strain at the notch edge region. Local ratcheting at the hole–pin interference region was analyzed by means of two kinematic-hardening rules—the Ahmadzadeh–Varvani (A–V) rule and the Chaboche rule—coupled with the Neuber rule. Ratcheting strains at the notch root of aluminum samples with DIF = 0 (non-press-fitting samples) were measured and found to be the highest in magnitude. For the press-fitted samples, however, ratcheting strains dropped noticeably as the DIF increased from 1% to 2%. The press-fitting process plastically deformed the perimeter edges of the notches and improved the materials strength locally at the notch edges, resulting in better resistance against ratcheting progress. Local ratcheting strains at distances of 0.5, 1.3, and 3.0 mm from the notch roots were predicted for both pinned and unpinned samples via the hardening rules and were compared with those of measured ratcheting values. The ratcheting curves predicted by means of the A-V and Chaboche hardening rules closely agreed with the experimental data. The predicted ratcheting curves were positioned, respectively, above and below the measured ratcheting data.
Influence of High-Temperature and Intense Light on the Enzymatic Antioxidant System in Ginger (Zingiber officinale Roscoe) Plantlets
Authors: Gong Min , Jiang Dongzhu , Liu Ran , Tian Shuming , Xing Haitao , Chen Zhiduan , Shi Rujie , Li Hong-Lei
Published: September 2023

Environmental stressors such as high temperature and intense light have been shown to have negative effects on plant growth and productivity. To survive in such conditions, plants activate several stress response mechanisms. The synergistic effect of high-temperature and intense light stress has a significant impact on ginger, leading to reduced ginger production. Nevertheless, how ginger responds to this type of stress is not yet fully understood. In this study, we examined the phenotypic changes, malonaldehyde (MDA) content, and the response of four vital enzymes (superoxide dismutase (SOD), catalase (CAT), lipoxygenase (LOX), and nitrate reductase (NR)) in ginger plants subjected to high-temperature and intense light stress. The findings of this study indicate that ginger is vulnerable to high temperature and intense light stress. This is evident from the noticeable curling, yellowing, and wilting of ginger leaves, as well as a decrease in chlorophyll index and an increase in MDA content. Our investigation confirms that ginger plants activate multiple stress response pathways, including the SOD and CAT antioxidant defenses, and adjust their response over time by switching to different pathways. Additionally, we observe that the expression levels of genes involved in different stress response pathways, such as SOD, CAT, LOX, and NR, are differently regulated under stress conditions. These findings offer avenues to explore the stress mechanisms of ginger in response to high temperature and intense light. They also provide interesting information for the choice of genetic material to use in breeding programs for obtaining ginger genotypes capable of withstanding high temperatures and intense light stress.
Report of the CCU/CCQM Workshop on “The Metrology of Quantities Which Can Be Counted”
Authors: Brown Richard J. C. , Güttler Bernd , Neyezhmakov Pavel , Stock Michael , Wielgosz Robert I. , Kück Stefan , Vasilatou Konstantina
Published: September 2023

This article provides a report of the recent workshop on “The metrology of quantities which can be counted” organised jointly by the International Committee for Weights and Measures’ Consultative Committees for Amount of Substance (CCQM) and for Units (CCU). The workshop aimed to trigger a discussion on counting and number quantities across the metrological community so that a common understanding of counting and a common nomenclature could be achieved and there was clarity on the differences between these increasingly important concepts. This article details the background to the workshop, provides a summary of the presentations given and the discussions on the topics raised. It also reports the conclusions, agreed actions and next steps resulting from the workshop.
A Hybrid Strategy for Profile Measurement of Micro Gear Teeth
Authors: Huang Guangyao , Bai Jiao , Feng Feng , Zeng Long , Feng Pingfa , Li Xinghui
Published: September 2023

A hybrid strategy is proposed to meet the challenge of obtaining the profile of micro gear teeth with a small modulus. Firstly, the contact probe segmentally obtained the falling flank profiles with an auxiliary lifting mechanism to avoid interference when it climbs on the rising slope. Then, the noncontact chromatic confocal displacement sensor efficiently acquired the gear peak positions to carry out the two-point error separation with the gear peak positions from the probe measurement. Finally, actual experiments were carried out to obtain the profile of a harmonic drive flexspline. Compared with the commercial ultraprecise profiler, the proposed method provides measurement results with a deviation of less than 20 μm. In conclusion, the hybrid strategy is feasible and accurate for drawing the micro gear teeth profile without any collision between the measuring probes and the measured workpiece.
An Ultra-Wide Band MIMO Antenna System with Enhanced Isolation for Microwave Imaging Applications
Authors: Kiani Saad Hassan , Savci Huseyin Serif , Munir Mehr E , Sedik Ahmed , Mostafa Hala
Published: September 2023

This paper introduces a novel two-port ultra-wideband (UWB) multiple-input multiple-output (MIMO) antenna system with enhanced isolation characteristics. The antenna, designed on a thin 0.787 mm RO5880 substrate, achieves a compact form factor of 52 × 26 mm2 and offers a wide bandwidth of 9.2 GHz (2.3 GHz to 11.5 GHz) while meeting the VSWR 2:1 criterion. Notably, the proposed antenna demonstrates an impressive increase in isolation, up to 16 dB, through the integration of a shared radiator with small rectangular slots, effectively reducing interference and improving overall performance. Furthermore, a comprehensive analysis of additional MIMO performance parameters, including the envelope correlation coefficient (ECC) and diversity gain, confirms their satisfactory limits, validating the potential of the proposed UWB-MIMO antenna for various UWB applications. The time domain analysis of the UWB antenna is also analyzed, and results are found to be within satisfactory limits. Simulation and measurement results further support the practicality and effectiveness of the antenna design, highlighting its compact size, wide bandwidth, and enhanced isolation characteristics, positioning it as a promising solution for advanced UWB microwave imaging systems.
Convolutional Neural Network Defect Detection Algorithm for Wire Bonding X-ray Images
Authors: Zhan Daohua , Huang Renbin , Yi Kunran , Yang Xiuding , Shi Zhuohao , Lin Ruinan , Lin Jian , Wang Han
Published: September 2023

To address the challenges of complex backgrounds, small defect sizes, and diverse defect types in defect detection of wire bonding X-ray images, this paper proposes a convolutional-neural-network-based defect detection method called YOLO-CSS. This method designs a novel feature extraction network that effectively captures semantic features from different gradient information. It utilizes a self-adaptive weighted multi-scale feature fusion module called SMA which adaptively weights the contribution of detection results based on different scales of feature maps. Simultaneously, skip connections are employed at the bottleneck of the network to ensure the integrity of feature information. Experimental results demonstrate that on the wire bonding X-ray defect image dataset, the proposed algorithm achieves mAP 0.5 and mAP 0.5–0.95 values of 97.3% and 72.1%, respectively, surpassing the YOLO series algorithms. It also exhibits certain advantages in terms of model size and detection speed, effectively balancing detection accuracy and speed.
The Anti-Breast Cancer Stem Cell Potency of Copper(I)-Non-Steroidal Anti-Inflammatory Drug Complexes
Authors: Johnson Alice , Feng Xiao , Singh Kuldip , Ortu Fabrizio , Suntharalingam Kogularamanan
Published: September 2023

Cancer stem cells (CSCs) are thought to be partly responsible for metastasis and cancer relapse. Currently, there are no effective therapeutic options that can remove CSCs at clinically safe doses. Here, we report the synthesis, characterisation, and anti-breast CSC properties of a series of copper(I) complexes, comprising of non-steroidal anti-inflammatory drugs (NSAIDs) and triphenylphosphine ligands (1–3). The copper(I) complexes are able to reduce the viability of breast CSCs grown in two- and three-dimensional cultures at micromolar concentrations. The potency of the copper(I) complexes towards breast CSCs was similar to salinomycin (an established anti-breast CSC agent) and cisplatin (a clinically used metallopharmaceutical). Cell-based studies showed that the copper(I) complexes are readily, and similarly, internalised by breast CSCs. The copper(I) complexes significantly increase the intracellular reactive oxygen species (ROS) levels in breast CSCs, and their ROS generation profile with respect to time is dependent on the NSAID component present. The generation of intracellular ROS by the copper(I) complexes could be part of the underlying mechanism by which they evoke breast CSC death. As far as we are aware, this is the first study to explore the anti-breast CSC properties of copper(I) complexes.
Oxidation of the Platinum(II) Anticancer Agent [Pt{(p-BrC6F4)NCH2CH2NEt2}Cl(py)] to Platinum(IV) Complexes by Hydrogen Peroxide
Authors: Ojha Ruchika , Junk Peter C. , Bond Alan M. , Deacon Glen B.
Published: September 2023

PtIV coordination complexes are of interest as prodrugs of PtII anticancer agents, as they can avoid deactivation pathways owing to their inert nature. Here, we report the oxidation of the antitumor agent [PtII(p-BrC6F4)NCH2CH2NEt2}Cl(py)], 1 (py = pyridine) to dihydroxidoplatinum(IV) solvate complexes [PtIV{(p-BrC6F4)NCH2CH2NEt2}Cl(OH)2(py)].H2O, 2·H2O with hydrogen peroxide (H2O2) at room temperature. To optimize the yield, 1 was oxidized in the presence of added lithium chloride with H2O2 in a 1:2 ratio of Pt: H2O2, in CH2Cl2 producing complex 2·H2O in higher yields in both gold and red forms. Despite the color difference, red and yellow 2·H2O have the same structure as determined by single-crystal and X-ray powder diffraction, namely, an octahedral ligand array with a chelating organoamide, pyridine and chloride ligands in the equatorial plane, and axial hydroxido ligands. When tetrabutylammonium chloride was used as a chloride source, in CH2Cl2, another solvate, [PtIV{(p-BrC6F4)NCH2CH2NEt2}Cl(OH)2(py)].0.5CH2Cl2,3·0.5CH2Cl2, was obtained. These PtIV compounds show reductive dehydration into PtII [Pt{(p-BrC6F4)NCH=CHNEt2}Cl(py)], 1H over time in the solid state, as determined by X-ray powder diffraction, and in solution, as determined by 1H and 19F NMR spectroscopy and mass spectrometry. 1H contains an oxidized coordinating ligand and was previously obtained by oxidation of 1 under more vigorous conditions. Experimental data suggest that oxidation of the ligand is favored in the presence of excess H2O2 and elevated temperatures. In contrast, a smaller amount (1Pt:2H2O2) of H2O2 at room temperature favors the oxidation of the metal and yields platinum(IV) complexes.
Plant Polyphenols and Their Potential Benefits on Cardiovascular Health: A Review
Authors: Iqbal Iram , Wilairatana Polrat , Saqib Fatima , Nasir Bushra , Wahid Muqeet , Latif Muhammad Farhaj , Iqbal Ahmar , Naz Rabia , Mubarak Mohammad S.
Published: September 2023

Fruits, vegetables, and other food items contain phytochemicals or secondary metabolites which may be considered non-essential nutrients but have medicinal importance. These dietary phytochemicals exhibit chemopreventive and therapeutic effects against numerous diseases. Polyphenols are secondary metabolites found in vegetables, fruits, and grains. These compounds exhibit several health benefits such as immune modulators, vasodilators, and antioxidants. This review focuses on recent studies on using dietary polyphenols to treat cardiovascular disorders, atherosclerosis, and vascular endothelium deficits. We focus on exploring the safety of highly effective polyphenols to ensure their maximum impact on cardiac abnormalities and discuss recent epidemiological evidence and intervention trials related to these properties. Kaempferol, quercetin, and resveratrol prevent oxidative stress by regulating proteins that induce oxidation in heart tissues. In addition, polyphenols modulate the tone of the endothelium of vessels by releasing nitric oxide (NO) and reducing low-density lipoprotein (LDL) oxidation to prevent atherosclerosis. In cardiomyocytes, polyphenols suppress the expression of inflammatory markers and inhibit the production of inflammation markers to exert an anti-inflammatory response. Consequently, heart diseases such as strokes, hypertension, heart failure, and ischemic heart disease could be prevented by dietary polyphenols.
Influence of Pre-Treatment and Drying Methods on the Quality of Dried Carrot Properties as Snacks
Authors: Ignaczak Anna , Salamon Agnieszka , Kowalska Jolanta , Marzec Agata , Kowalska Hanna
Published: September 2023

The aim of the current research was to evaluate the effect of pre-treatment and drying methods on the properties of dried carrots. Carrots were blanched (B) (1 or 3 min) or osmotic dehydrated (OD) (15 or 30 min) and dried by either convection (CD), microwave-convection (MW-CD), microwave-vacuum (MVD), or freeze-drying (FD). FD carrots showed the highest dry matter content (93.6–95.8%) and the lowest water activity (0.24–0.38). MVD carrots had lower dry matter content (79.5–95.8%) and two times more water activity (0.447–0.637) than FD. The highest color difference (∆E) in relation to raw material was noted in MVD samples (22–35) and the smallest in CD and FD (7–18), mainly due to the increase in brightness of the dried carrot. In general dried MCD carrot samples were characterized by the highest max force (hardness) (21.6–42.5 N; on average 34.7 N) in the breaking test and the lowest hardness was observed in the CD (10.8 N) ones. Pre-treatment and drying caused a significant decrease in the content of carotenoids (2.0–2.7 times) and chlorophyll (2.7–4.5 times) compared to the fresh carrot but a retention or increase in the total content of phenolics and antioxidant activity, especially in microwave-vacuum-dried carrots with an increase of even 2.7–2.9 times compared to raw material. High phenolic content (195.6–277.4 mg GA/100 g d.m.) was found in pre-osmotic dehydrated samples, and lower phenolic content was found in blanched samples (110.7–189.6 mg GA/100 g d.m.). Significantly, the highest average antioxidant activity was found in microwave-vacuum-dried samples (228.9 µmol Trolox/100 g d.m.). The results of this study indicate that microwave-vacuum-drying as an alternative to freeze-drying, including in combination with thermal or osmotic treatment, is very promising for the production of dried carrot snacks.
Overview of the Metallization Approaches for Carbyne-Based Devices
Authors: Tomov Rade , Aleksandrova Mariya
Published: September 2023

Metallization for contacts in organic electronic nanodevices is of great importance for their performance. A lot of effects can appear at the contact/organic interface and modify the contact parameters, such as contact resistance, adhesive strength, and bonding ability. For novel materials, it is important to study the interactions with metal atoms to develop a suitable technology for contacts, fulfilling to the greatest extent the above-mentioned parameters. A novel material is carbyne, which is still under intensive research because of its great potential in electronics, especially for sensing applications. However, the most appropriate metallization strategy for carbyne-based devices is still unknown, so the interactions between carbyne and metal films should be studied to more precisely direct the development of the metallization technology, and to form contacts that are not limiting factors for device performance.
Docking and Molecular Dynamics Simulations Clarify Binding Sites for Interactions of Novel Marine Sulfated Glycans with SARS-CoV-2 Spike Glycoprotein
Authors: Samanta Priyanka , Mishra Sushil , Pomin Vitor , Doerksen Robert
Published: September 2023

The entry of SARS-CoV-2 into the host cell is mediated by its S-glycoprotein (SGP). Sulfated glycans bind to the SGP receptor-binding domain (RBD), which forms a ternary complex with its receptor angiotensin converting enzyme 2. Here, we have conducted a thorough and systematic computational study of the binding of four oligosaccharide building blocks from novel marine sulfated glycans (isolated from Pentacta pygmaea and Isostichopus badionotus) to the non-glycosylated and glycosylated RBD. Blind docking studies using three docking programs identified five potential cryptic binding sites. Extensive site-targeted docking and molecular dynamics simulations using two force fields confirmed only two binding sites (Sites 1 and 5) for these novel, highly charged sulfated glycans, which were also confirmed by previously published reports. This work showed the structural features and key interactions driving ligand binding. A previous study predicted Site 2 to be a potential binding site, which was not observed here. The use of several molecular modeling approaches gave a comprehensive assessment. The detailed comparative study utilizing multiple modeling approaches is the first of its kind for novel glycan–SGP interaction characterization. This study provided insights into the key structural features of these novel glycans as they are considered for development as potential therapeutics.
The Defect Passivation of Tin Halide Perovskites Using a Cesium Iodide Modification
Authors: He Linfeng , Cheng Jin , Zhao Longjiang , Chen Xinyao , Zou Xiaoping , Zhang Chunqian , Li Junming
Published: September 2023

Tin-based perovskites are promising for realizing lead-free perovskite solar cells; however, there remains a significant challenge to achieving high-performance tin-based perovskite solar cells. In particular, the device fill factor was much lower than that of other photovoltaic cells. Therefore, understanding how the fill factor was influenced by device physical mechanisms is meaningful. In this study, we reported a method to improve the device fill factor using a thin cesium iodide layer modification in tin-based perovskite cells. With the thin passivation layer, a high-quality perovskite film with larger crystals and lower charge carrier densities was obtained. As a result, the series resistance of devices was decreased; the shunt resistance of devices was increased; and the non-radiative recombination of devices was suppressed. Consequently, the fill factor, and the device efficiency and stability were greatly enhanced. The champion tin-based perovskite cells showed a fill factor of 63%, an efficiency of 6.1% and excellent stability. Our study reveals that, with a moderate thin layer modification strategy, the long-term stability of tin-based PSCs can be developed.
Antimicrobial Properties and Assessment of the Content of Bioactive Compounds Lavandula angustifolia Mill. Cultivated in Southern Poland
Authors: Betlej Izabela , Andres Bogusław , Cebulak Tomasz , Kapusta Ireneusz , Balawejder Maciej , Jaworski Sławomir , Lange Agata , Kutwin Marta , Pisulewska Elżbieta , Kidacka Agnieszka , Krochmal-Marczak Barbara , Borysiuk Piotr
Published: September 2023

Lavender is a valued plant due to its cosmetic, perfumery, culinary, and health benefits. A wide range of applications is related to the composition of bioactive compounds, the quantity and quality of which is determined by various internal and external factors, i.e., variety, morphological part of the plant, and climatic and soil conditions during vegetation. In the presented work, the characterization of antimicrobial properties as well as the qualitative and quantitative assessment of bioactive compounds in the form of polyphenols in ethanol extracts from leaves and flowers of Lavandula angustifolia Mill. intended for border hedges, cultivated in the region of southern Poland, were determined. The composition of the fraction of volatile substances and antioxidant properties were also assessed. The conducted research shows that extracts from leaves and flowers significantly affected the viability of bacterial cells and the development of mold fungi. A clear decrease in the viability of bacteria and C. albicans cells was shown in the concentration of 0.32% of extracts. Leaf extracts were characterized by a much higher content of polyphenols and antioxidant properties than flower extracts. The composition of volatiles measured by GC-MS was significantly different between the extracts. Linalyl acetate and ocimene isomers mix dominated in flower extracts, whereas coumarin, γ-cadinene, and 7-methoxycoumarin were identified as dominant in leaf extracts.
Fabrication and Investigation of the Microwave Absorption of Nonwovens Modified by Carbon Nanotubes and Graphene Flakes
Authors: Gu Wenyan , Shi Jiang , Zhang Jiaqiao , Jia Qi , Liu Chengwei , Ge Haiyan , Sun Qilong , Zhu Licheng
Published: September 2023

This study aims to investigate the influences of carbon nanotubes (CNTs) and graphene flakes (GFs) on the microwave absorption performance of nonwovens. Nonwovens were modified with CNTs and GFs through an impregnation method, creating a series of absorption samples with different carbon nanomaterial contents. Then the absorption performance of the samples was tested on both sides in the X-band (8.2~12.4 GHz) and the Ku-band (12~18 GHz) using the arch method. The experimental results showed that the absorption performance of GF-impregnated nonwovens was superior to that of CNT-impregnated nonwovens, and the overall absorption performance in the Ku-band was better than in the X-band. At a CNT content of 5 wt.%, the reflection loss of the impregnated nonwovens on the backside reached a minimum of −14.06 dB and remained below −10 dB in the 17.42~17.88 GHz frequency range. The sample fabricated with 4 wt.% GFs in the impregnation solution exhibited the best absorption performance, with minimum reflection losses of −15.33 dB and −33.18 GHz in the X-band and Ku-band, respectively. When the GFs were at 3 wt.%, the absorption bandwidth below −10 dB reached 4.16 GHz. In contrast to CNT-impregnated nonwovens, the frontside of GF-impregnated nonwovens demonstrated better absorption performance in the Ku-band. The results of this work provide experimental data support for the fabrication and application of microwave absorption materials.
The Research Progress of Bioactive Peptides Derived from Traditional Natural Products in China
Authors: Zhang Yanyan , Liu Lianghong , Zhang Min , Li Shani , Wu Jini , Sun Qiuju , Ma Shengjun , Cai Wei
Published: September 2023

Traditional natural products in China have a long history and a vast pharmacological repertoire that has garnered significant attention due to their safety and efficacy in disease prevention and treatment. Among the bioactive components of traditional natural products in China, bioactive peptides (BPs) are specific protein fragments that have beneficial effects on human health. Despite many of the traditional natural products in China ingredients being rich in protein, BPs have not received sufficient attention as a critical factor influencing overall therapeutic efficacy. Therefore, the purpose of this review is to provide a comprehensive summary of the current methodologies for the preparation, isolation, and identification of BPs from traditional natural products in China and to classify the functions of discovered BPs. Insights from this review are expected to facilitate the development of targeted drugs and functional foods derived from traditional natural products in China in the future.
Advances in Nanomaterials Based on Cashew Nut Shell Liquid
Authors: Bloise Ermelinda , Lazzoi Maria Rosaria , Mergola Lucia , Del Sole Roberta , Mele Giuseppe
Published: September 2023

Cashew nut shell liquid (CNSL), obtained as a byproduct of the cashew industry, represents an important natural source of phenolic compounds, with important environmental benefits due to the large availability and low cost of the unique renewable starting material, that can be used as an alternative to synthetic substances in many industrial applications. The peculiarity of the functional groups of CNSL components, such as phenolic hydroxyl, the aromatic ring, acid functionality, and unsaturation(s) in the C15 alkyl side chain, permitted the design of interesting nanostructures. Cardanol (CA), anacardic acid (AA), and cardol (CD), opportunely isolated from CNSL, served as building blocks for generating an amazing class of nanomaterials with chemical, physical, and morphological properties that can be tuned in view of their applications, particularly focused on their bioactive properties.
Adverse Effect of Metallic Gold and Silver Nanoparticles on Xenopus laevis Embryogenesis
Authors: Carotenuto Rosa , Tussellino Margherita , Fusco Sabato , Benvenuto Giovanna , Formiggini Fabio , Avallone Bice , Motta Chiara Maria , Fogliano Chiara , Netti Paolo Antonio
Published: September 2023

Exposure to metal nanoparticles is potentially harmful, particularly when occurring during embryogenesis. In this study, we tested the effects of commercial AuNPs and AgNPs, widely used in many fields for their features, on the early development of Xenopus laevis, an anuran amphibian key model species in toxicity testing. Through the Frog Embryo Teratogenesis Assay—Xenopus test (FETAX), we ascertained that both nanoparticles did not influence the survival rate but induced morphological anomalies like modifications of head and branchial arch cartilages, depigmentation of the dorsal area, damage to the intestinal brush border, and heart rate alteration. The expression of genes involved in the early pathways of embryo development was also modified. This study suggests that both types of nanoparticles are toxic though nonlethal, thus indicating that their use requires attention and further study to better clarify their activity in animals and, more importantly, in humans.
Cu-Based Thermocompression Bonding and Cu/Dielectric Hybrid Bonding for Three-Dimensional Integrated Circuits (3D ICs) Application
Authors: Huang Yuan-Chiu , Lin Yu-Xian , Hsiung Chien-Kang , Hung Tzu-Heng , Chen Kuan-Neng
Published: September 2023

Advanced packaging technology has become more and more important in the semiconductor industry because of the benefits of higher I/O density compared to conventional soldering technology. In advanced packaging technology, copper–copper (Cu-Cu) bonding has become the preferred choice due to its excellent electrical and thermal properties. However, one of the major challenges of Cu-Cu bonding is the high thermal budget of the bonding process caused by Cu oxidation, which can result in wafer warpage and other back-end-of-line process issues in some cases. Thus, for specific applications, reducing the thermal budget and preventing Cu oxidation are important considerations in low-temperature hybrid bonding processes. This paper first reviews the advancements in low-temperature Cu-based bonding technologies for advanced packaging. Various low-temperature Cu-Cu bonding techniques such as surface pretreatment, surface activation, structure modification, and orientation control have been proposed and investigated. To overcome coplanarity issues of Cu pillars and insufficient gaps for filling, low-temperature Cu-Cu bonding used, but it is still challenging in fine-pitch applications. Therefore, low-temperature Cu/SiO2, Cu/SiCN, and Cu/polymer hybrid bonding have been developed for advanced packaging applications. Furthermore, we present a novel hybrid bonding scheme for metal/polymer interfaces that achieves good flatness and an excellent bonding interface without the need for the chemical mechanical polishing (CMP) process.
Cost of Acute Malnutrition Treatment Using a Simplified or Standard Protocol in Diffa, Niger
Authors: Cichon Bernardette , Lopez Ejeda Noemi , Charle Cuellar Pilar , Hamissou Issa Ango , Karim Ali Amadou Abdoul , Aton Cornelia , Sanoussi Atté , Ousmane Nassirou , Lazoumar Ramatoulaye Hamidou , Gado Abdoul Aziz Ousmane , Harouna Zakou Yassi , Oteyza Saul Guerrero
Published: September 2023

Evidence on the cost of acute malnutrition treatment, particularly with regards to simplified approaches, is limited. The objective of this study was to determine the cost of acute malnutrition treatment and how it is influenced by treatment protocol and programme size. We conducted a costing study in Kabléwa and N’Guigmi, Diffa region, where children with acute malnutrition aged 6–59 months were treated either with a standard or simplified protocol, respectively. Cost data were collected from accountancy records and through key informant interviews. Programme data were extracted from health centre records. In Kabléwa, where 355 children were treated, the cost per child treated was USD 187.3 (95% CI: USD 171.4; USD 203.2). In N’Guigmi, where 889 children were treated, the cost per child treated was USD 110.2 (95% CI: USD 100.0; USD 120.3). Treatment of moderate acute malnutrition was cheaper than treatment of severe acute malnutrition. In a modelled scenario sensitivity analysis with an equal number of children in both areas, the difference in costs between the two locations was reduced from USD 77 to USD 11. Our study highlighted the significant impact of programme size and coverage on treatment costs, that cost can differ significantly between neighbouring locations, and that it can be reduced by using a simplified protocol.
Changes in Body Mass Index and Their Associations with Psychological Distress, Worries, and Emotional Eating during the COVID-19 Pandemic: A Norwegian Cohort Study
Authors: Arjmand Elaheh Javadi , Skogen Jens Christoffer , Vold Jørn Henrik , Alpers Silvia Eiken , Arnesen Erik Kristoffer , Mæland Silje , Fadnes Lars Thore
Published: September 2023

In 2020, the COVID-19 pandemic highlighted obesity’s long-term rise. Some of the impacts of the pandemic were increased psychological distress, emotional eating, higher consumption of high-sugar foods and drinks, and a more sedentary lifestyle. This study examined BMI changes over time and their associations with psychological distress and lifestyle changes. This population-based cohort study had 24,968 baseline participants and 15,904 and 9442 one- and two-year follow-ups, respectively. Weight, height, psychological distress, high-sugar foods and drinks, physical activity, and emotional eating were assessed. These factors and BMI were examined at baseline and over time. We used mediation analyses and structural equation modeling to determine how psychological distress affects BMI. The mean BMI was 25.7 kg/m2 at baseline and 26.2 kg/m2 at two years. High psychological distress, daily emotional eating, and low physical activity were associated with higher BMI at baseline and higher yearly increases in BMI compared to reference levels. Emotional eating mediated 33% of the psychological distress BMI effect. Overall, BMI increased during the pandemic. Psychological distress during the pandemic was linked to weight gain partly through emotional eating. This association remained strong over time during different stages of the pandemic.
Consumer Interaction with Sustainability Labelling on Food Products: A Narrative Literature Review
Authors: Cook Brian , Costa Leite João , Rayner Mike , Stoffel Sandro , van Rijn Elaine , Wollgast Jan
Published: September 2023

Sustainability labelling on food products can help consumers make informed purchasing decisions and support the urgent transition to sustainable food systems. While there is a relatively robust body of evidence on health and nutrition labelling, less is known about the effectiveness of sustainability labelling in facilitating sustainable food choices. This paper investigates the impact of sustainability labelling on consumer understanding, attitudes, and behaviour to support a more nuanced, detailed, and holistic understanding of the evidence. Using a narrative literature review methodology, the paper assesses studies covering environmental, social, and/or animal welfare aspects of sustainability labelling on food products. We found that consumer understanding of sustainability information is often limited, which could hinder behaviour change. While sustainability labelling can influence consumer attitudes and purchasing behaviours, evidence from real consumer settings tends to show small effect sizes. Consumers are generally willing to pay more for sustainability-labelled products, and organic labelling often leads to the highest reported willingness to pay. The review emphasises the importance of trust, suggesting a preference for labelling backed by governments or public authorities. Sustainability labelling that uses intuitively understandable cues has an increased impact, with visual aids such as traffic light colours showing promise. We conclude that further research is needed in real-world settings, using representative populations and exploring the influence of demographic factors, values, and attitudes.
Impact of 12 Weeks of Vitamin D3 Administration in Parkinson’s Patients with Deep Brain Stimulation on Kynurenine Pathway and Inflammatory Status
Authors: Bytowska Zofia Kinga , Korewo-Labelle Daria , Kowalski Konrad , Libionka Witold , Przewłócka Katarzyna , Kloc Wojciech , Kaczor Jan Jacek
Published: September 2023

The current study aimed to investigate whether a 12-week Body Mass Index (BMI)-based (the higher the BMI, the higher the dosage) vitamin D3 administration may affect both the kynurenine pathway (KP) and the inflammatory state in Parkinson’s disease (PD) patients with deep brain stimulation (DBS) and may be useful for developing novel therapeutic targets against PD. Patients were randomly assigned to two groups: supplemented with vitamin D3 (VitD, n = 15) and treated with vegetable oil (PL, n = 21). Administration lasted for 12 weeks. The isotope dilution method by LC-MS/MS was applied to measure KP and vitamin D metabolites. Serum concentrations of cytokines such as IL-6 and TNF-α were measured using ELISA kits. After administration, the serum concentration of TNF-α decreased in PD patients with DBS. Moreover, in KP: 3-hydroksykynurenine (3-HK) was increased in the PL group, picolinic acid was decreased in the PL group, and kynurenic acid tended to be higher after administration. Furthermore, a negative correlation between 3-HK and 25(OH)D3 and 24,25(OH)2D3 was noticed. Our preliminary results provide further evidence regarding a key link between the KP substances, inflammation status, and metabolites of vitamin D in PD patients with DBS. These findings may reflect the neuroprotective abilities of vitamin D3 in PD patients with DBS.