bluuebunny/crossref_metadata_2025 huggingface dataset:
Alterations of Methylated Arginine Residues and Related Amino Acids During Acute Pancreatic Inflammation
Authors: CİZMECİOGLU Ahmet , ERYAVUZ ONMAZ Duygu , AYDİN Huseyin Emre , SENTURK Suleyman , UNLU Ali , KORKMAZ Huseyin , GÜNGÖR Gökhan
Published: October 2022

Aim: The extent of the spread of inflammation determines the severity of acute pancreatitis (AP). Methylated arginine residues (MAR), a type of inflammatory mediator, reduce nitric oxide levels and cause vasoconstriction-induced endothelial damage. This study aimed to investigate MAR and related amino acids during acute pancreatic inflammation.

Material and Method: This prospective, quasi-experimental study was conducted with patients diagnosed with AP and an age-matched control group. The patient samples were taken during the diagnosis and recovery time, whereas during the study for the control group. Mainly, Asymmetric dimethylarginine (ADMA), Arginine (ARG), Citrulline (CIT), and related chemicals were studied via a mass spectrometer.

Results: A total of 30 patients with AP (mean age=53.3±17.8) and 30 controls (mean age=53.4±18.0) were included in the study. All patients were identified as non-severe (n=8) and severe (n=22). A decrease was detected in the patients' ADMA levels compared to the control group (p=0.01). MAR did not differ concerning disease severity (p > 0.05). However, MAR levels decreased higher in patients with diabetes or chronic kidney disease (CKD). Between the two samplings, the ARG level and ARG to ADMA ratio increased, while the MAR and CIT to ARG ratio decreased.

Conclusion: Our results showed that MAR levels decreased with AP recovery. The start of a decrease in the high-level blood MAR may indicate the healing of pancreatic inflammation. AP inflammation may be more destructive in patients with diabetes or CKD.
The Role of Inflammatory Markers in the Differential Diagnosis of Skin Cancers
Authors: DEREBAŞINLIOĞLU Handan , DEMİR Hande , NEMMEZİ KARACA Sanem
Published: October 2022

Aim: The purpose of this study was to evaluate the role of WBC count, NLR, LMR, PLR, Systemic immune-inflammation index (SII) [(platelet count X neutrophil count) \ lymphocyte count] and platelet count (Plt)×NLR in the differential diagnosis of basal cell carcinoma, squamous cell carcinoma, and malignant melanoma and to determine the effect of tumor type, prediction of lymph node metastasis at initial diagnosis and location on these inflammatory markers. Material and Method: Patients who underwent surgery for basal cell carcinoma, squamous cell carcinoma, or malignant melanoma were retrospectively screened. NLR, LMR, PLR, SII and Plt×NLR were calculated. Relationships between tumor type, prediction of lymph node metastasis at initial diagnosis, tumor localization and the inflammatory and hematological parameters of interest were investigated. Tumor location was classified as head and neck and others. Results: A total of 257 patients were included in the study. No statistically significant differences in WBC, NLR, PLR, LMR, SII or Plt×NLR were detected according to tumor location. The patients with squamous cell carcinoma had higher NLR, PRL, SII and Plt×NLR values than those with basal cell carcinoma. The risk of lymph node metastasis at the time of initial diagnosis was 10.3 times higher in patients with PLR levels of 180.7 and higher. The risk of lymph node metastasis detected at initial diagnosis was 8.9 times higher in patients with Plt×NLR of 747 and higher. The risk of lymph node metastasis detected at initial diagnosis was 7.1 times higher in patients with SII of 414 and higher. Conclusion: Inflammatory markers seem to be useful in the differential diagnosis of skin cancers and determined the risk of lymph node metastasis. However, it does not differ according to tumor localization.
The Importance of Morphometric Measurements of Adult Human Dry Hip Bone in Acetabular Reconstruction
Authors: AÇIKGÖZ A. Kürşad , BOZKIR Memduha Gülhal
Published: October 2022

Objective: The aim of this study was to obtain morphometric measurements of adult human hip bones, examine the relationship among these measurement parameters, and develop regression equations to estimate the acetabular dimensions for acetabular reconstruction

Material and Method: Seventy-eight (39 right and 39 left) dry hip bones of unknown age and gender located in the laboratory of Çukurova University Faculty of Medicine, Department of Anatomy, were included in the study. Eleven hip bones with fractures, deterioration, deformities, and defects that would affect the measurements were excluded from the study. In our study, 14 morphometric measurements of hip bones were obtained. IBM SPSS program was used for statistical analysis.

Results: Single and multiple regression equations were developed from the hip bone morphometric measurements for the estimation of the morphometric measurements of the acetabulum. The standard error of estimate (SEE) values ranged from ±1.818 mm to ±3.546 mm in single regression equations, and between ±1.633 mm and ±2.107 mm in multiple regression equations. A lower SEE value was obtained in multiple regression equations than in single regression equations.

Conclusion: The regression equations developed in this study will allow us to obtain personalized measurements, which will aid clinicians in the correct and safe placement of the implant in hip replacement surgeries as well as in the prevention of complications with the use of appropriate prostheses.
Predicting Gestational Diabetes Mellitus Using The Systemic Immune-Inflammation Index in The First Trimester
Authors: CEVHER AKDULUM Munire Funda , DEMİRDAĞ Erhan , SAHİLA Safarova , ERDEM Mehmet , ERDEM Ahmet
Published: October 2022

Aims: Gestational diabetes mellitus (GDM) is an inflammatory disorder. GDM raises the risk of pregnancy complications. Early recognition of GDM is critical to prevent complications. Systemic Immune-Inflammation Index (SII) is an index that shows the inflammatory response, we hypothesized that it might be associated to GDM. The purpose of this study was to determine the relationship between GDM and SII, as well as whether SII in the first trimester can predict GDM.

Material and Method: This retrospective cohort study was conducted between January 2021 and January 2022. 100 pregnant women were included in the study. The study group included 50 pregnant women who had been diagnosed with GDM. The control group consisted of the remaining 50 pregnant women who had not been diagnosed with GDM. SII values were calculated from the hemogram values of the patients at the first visit in the first trimester.

Results: There was a statistically significant difference between GDM and control groups in terms of SII, platelet, neutrophil, fT3, apgar 1 min and apgar 5 min measurements (p
Adolescent-Parent Agreement in terms of Symptoms of Adolescents Diagnosed with Anxiety Disorder
Authors: ARICI GÜRBÜZ Asiye , KUYGUN KARCI Canan
Published: October 2022

Aim: Considering the role of the parent in the children and adolescent's access to treatment, it is important that the symptoms are adequately noticed by the parents. In this study, it was aimed to examine the adolescent-parent agreement in terms of symptoms of adolescents with anxiety disorder.

Material and Method: 100 adolescents who applied to the child and adolescent psychiatry outpatient clinic and were diagnosed with anxiety disorder according to the DSM-5 diagnostic criteria were included in the study. In the study, the sociodemographic form and the Revised Child Anxiety and Depression Scale (RCADS) adolescent and parent form were used for data collection.

Results: When the parent and adolescent forms of RCADS were compared, the adolescent scores were significantly higher than the parents in all subscales and scale total scores, except for the separation anxiety subscale. The ICC (95% CI) value between the parent and adolescent forms of RCADS ranged from 0.06 to 0.74.

Conclusion: In our study, it was found that adolescents scored their symptoms higher than their parents, and the correlation between parent-child reporting was low-moderate. Age, gender, comorbidity, and parental psychopathology were among the factors affecting adolescent-parent agreement.
Prevalence and Severity of the Restless Leg Syndrome in Patients with Hip and Knee Osteoarthritis
Authors: ZİNCİR ERÇİN Dilek Özge , ÖZLÜ Aysun
Published: October 2022

Aim: To investigate Restless legs syndrome (RLS) if the prevalence, severity, pain levels, sleep hygiene and quality of life differs hip and knee osteoarthritis (OA).

Material and Method: Between January, 2, 2020- June, 2, 2020, 103 patients with knee OA and 98 with hip OA between 55 and 75 years of age corresponding inclusion and exclusion criteria were recorded. The visual analog scale (VAS) for pain severity, the Lequesne severity index for the severity of OA, the Sleep Hygiene Indes for frequency and severity of RLS symptoms and sleep behaviors, and Nottingham Health Profile (NHP) was used for assessment of overall health.

Results: The RLS symptom severity, the RLS duration, VAS general and at night, sleep hygiene index and NHP sleep, energy and NHP Section 1 and Section 2 parameters were significantly higher in the Knee OA than the hip OA. A strongly positive correlation was detected between RLS severity and RLS duration, Body Mass İndex and Leq Hip scores; however, a poor correlation was detected between night VAS, sleep NHP and physical NHP parameters. A strongly positive correlation was detected between RLS duration and sleep NHP, Leq Knee OA severity, and grade.

Conclusion: It was concluded that in the treatment and follow-up of RLS, it should be aimed to increase the quality of life of the patients by following the treatment of hip and knee osteoarthritis along with weight control of the patients.
Effect of Gleno-humeral-capsulo-Ligamentous Stretch Maneuvers on Range of motion in Bilateral Frozen Shoulder
Authors:   Intern, Department of physiotherapy, Krishna Institute of Medical Sciences “Deemed to be” University, Karad, Maharashtra, India., Shahjahan Mariya , Patil Smita ,   Head of Sports department, Department of physiotherapy, Krishna Institute of Medical Sciences “Deemed to be” University,Karad, Maharashtra, India.
Published: October 2022

Background: Painful restriction of shoulder movement, without an underlying cause, which results in complete loss of motion of the glenohumeral joint is called Frozen Shoulder. The process is started with an inflammation of the lining of the joint within the shoulder. Gradually this area thickens and results in the shoulder becoming stiffer and more painful. It is seen commonly at the age of 40-65 years and more often in women. Overall, this condition affects work, leisure, and quality of life. Frozen shoulder often progresses in three stages: the freezing, frozen and thawing phases. Risk factors for frozen shoulder are diabetes, thyroid, history of shoulder trauma, cervical radiculopathy, post-operative immobilization, and shoulder surgery. Cyriax described the typical capsular patterns of the gle¬no humeral joint in the frozen shoulder with abduction more limited than external rotation, and external rota¬tion more limited than internalrotation. This study aims to establish the effect of gleno humeral capsulo ligamentous stretch maneuvers on bilateral frozen shoulder. Methods: A total of 40 subjects diagnosed with bilateral frozen shoulder were selected for the study. Subjects received low load prolonged stretching, mobilization and shoulder range of motion exercises. Each session was conducted for 30 minutes duration, 5 days per week for 4 weeks. Outcome measures used were Numerical pain rating scale (NPRS), Goniometer and Shoulder Pain and Disability Index (SPADI). Results: The results of the study demonstrate that there was a significant effect of gleno humeral capsulo ligamentous stretch on numerical pain rating scale (p<0.0001), range of motion (Shoulder flexion, abduction, internal rotation and external rotation (p<0.0001), Shoulder pain and disability index (p<0.0001) during the pre and post intervention assessment. Conclusion: It is concluded that that the use of low load prolonged stretch and mobilization was very effective in reducing pain and improving range of motion. Shoulder range of motion exercises was effective in improving strength and flexibility of shoulder musculature. KEYWORDS: Low load prolonged stretch, mobilization, numerical pain rating scale, Shoulder pain and disability index, Bilateral frozen shoulder.
IMPROVEMENT IN PERFORMANCE OF THE CENTRAL AUDITORY SYSTEM IN TYPE 1 NEUROFIBROMATOSIS
Authors: Fontanelli Raquel , Aragão Marcelo , Pinho Ricardo , Gil Daniela
Published: October 2022

Background

The aim was to electrophysiologically evaluate changes in the peripheral and central auditory systems in individuals with neurofibromatosis type 1 who underwent formal auditory training.

Material and methods

The sample consisted of 6 individuals aged between 9 and 15 years. The procedures involved anamnesis, meatoscopy, brainstem auditory potentials and long-latency evoked potentials, and behavioral tests of central auditory processing. All individuals were given 9 weekly sessions of formal auditory training.

Results

After therapeutic intervention we observed improved performance in auditory closure (p = 0.014) and figure–background discrimination for verbal sounds (p = 0.025). There were no significant changes in brainstem auditory evoked potentials. However, the P300 of the longlatency auditory evoked potential showed significant differences for the left ear in terms of latencies of waves N2 (p = 0.05) and P3 (p = 0.05) and the amplitude of N2–P3 (p = 0.05).

Conclusions

Therapeutic intervention by means of formal auditory training is effective in rehabilitating central auditory processing disorder. There were improved responses in both behavioral and electrophysiological assessments, which were maintained for at least 4 months.
REPORTING OF PATIENT-REPORTED OUTCOMES IN RCTS FOCUSED ON TINNITUS: A META STUDY
Authors: Bacani Rigel , Snider Kelsey , Jacobsen Sam , Ladd Chase , Heigle Benjamin , Kee Micah , Hillman Cody , Ottwell Ryan , Hartwell Micah , Vassar Matt
Published: October 2022

Background

The inclusion of patient-reported outcomes (PROs) in randomized controlled trials (RCTs) supplements outcomes of treatment efficacy with the patient’s perspectives. The aim of this study was to evaluate reporting completeness of PROs in RCTs pertaining to tinnitus, using the Consolidated Standards of Reporting Trials (Consort-PRO) adaptation.

Material and methods

We performed a search of Medline, Embase, and Cochrane Central Register of Controlled Trials (Central) for published RCTs related to tinnitus with at least one PRO measure from 2006 to 2020. Two investigators screened RCTs for inclusion. Using the Consort-PRO adaptation in an independent, masked fashion, investigators then evaluated all included RCTs. Similarly, all RCTs were evaluated using the Cochrane Collaboration Risk of Bias 2.0 tool. To assess relationships between trial characteristics and completeness of reporting, bivariate
regression analyses were used.

Results

From 878 publications, 37 RCTs met inclusion criteria. The mean Consort-PRO completeness of reporting across RCTs was 51.2% (SD = 20.8). Evaluation of our secondary outcome – assessment of study characteristics – demonstrated significantly higher completeness of
reporting when (1) the Consort guideline was mentioned within the RCT (p = 0.01); (2) trials had ‘some concerns’ for bias (p = 0.001); and (3) trials had ‘low’ risk of bias (p = 0.001).

Conclusions

Our study found that there was subpar Consort-PRO adherence within tinnitus RCTs. Due to the variance in symptom severity in tinnitus and the importance of PROs to clinical practice, we recommend journals include instructions to authors to use the Consort-PRO guideline before they publish RCTs.
Laboratory risk factors for mortality in severe and critical COVID-19 patients admitted to the ICU v1
Authors: Bestari Garidya
Published: October 2022

Background :Several studies have reported clinical characteristics and risk factors for predicting adverse outcomes in COVID-19.4–6 However, data exclusively from the ICU especially in the low- and middle-income countries (LMIC) remain lacking. This study aimed to explore risk factors associated with mortality based on laboratory parameters at hospital admission in severe and critical COVID-19 patients admitted to the ICU. Methods : This study is a retrospective cohort study.Data from the electronic medical records were collected retrospectively from all severe and critical COVID-19 patients requiring ICU admission in two designated COVID-19 hospitals in Jakarta, Indonesia. A multivariate logistic regression analysis was used to identify the predictors associated with ICU mortality. The model performance was evaluated by the area under curve (AUC) from the receiver operating characteristic (ROC) analysis. Results :There were 334 patients admitted to the ICU with COVID-19 included in the statistical analysis. The ICU mortality rate was 75.1%, with 251 patients died in the hospital. Independent risk factors associated mortality including white blood cell count >13.9 x109/L (OR=2.41; 95% CI, 1.15-5.06, p=0.02), neutrophil to lymphocyte ratio >10.7 (OR=2.20; 95% CI, 1.20 – 4.03, p=0.011), and creatinine >0.8 mg/dL (OR=3.55; 95% CI, 2.05 – 6.17, p<0.001). The model yielded an AUC of 0.72 (95% CI, 0.659-0.780, p<0.0001) for predicting ICU mortality in severe and critical COVID-19 patients. Conclusions :White blood cell, neutrophil to lymphocyte ratio, and serum creatinine on hospital admission are significant predictors of mortality in severe and critical COVID-19 patients admitted to the ICU.The ICU mortality rate during the second wave of the pandemic in this study was high.
MagAttract + Metapolyzyme metagenomic gDNA extraction from skin swabs v2
Authors: Ring Natalie
Published: October 2022

A protocol for the metagenomic extraction of bacterial DNA from skin swab samples (optimised using canine swabs), for use in a rapid diagnostics pipeline. At the end of the protocol, the DNA is cleaned up and ready for rapid barcoding (SQK-RBK004) library preparation for nanopore sequencing (or whatever other application you want to do). Unless otherwise stated, all reagents should be included in the listed kits.
Online Brazilian Journal of Nursing 2007 Thanks to Peer Reviewers and Authors
Authors: Cruz Isabel CF da
Published: October 2022

The editor thanks the OBJN Reviewers and Authors for their competent service during the year 2007.
Nosocomial infections and bacterial resistance in patients from a Teaching Hospital Intensive Care Unit
Authors: Oliveira Adriana Cristina , Horta Bruno , Martinho Glaucia Helena , Villa Dantas Lorena , Marques Ribeiro Maíra
Published: October 2022

The Intensive Care Units represent an important and indispensable part of the modern medicine, for offering services to critically sick patients, using specialized human resources and advanced technology. In this study it was aimed to determine the incidence of the nosocomial infection, its possible relationship with the occurrence of the colonization by resistant microorganisms, the main agents of that colonization, and the mortality rate in that unit. It was a prospective and descriptive study, from August 2005 to July 2006. The data were collected from medical records and consultation to the microbiologic database. The global infection rate was 23,8%, the colonization for resistant microorganisms contributed to the development of infection (RR=6,8 [4,8-9,6], p
Research groups in Brazil: the woman health from the breastfeeding subject
Authors: Moreira Michelle Araújo , Lopes Regina Lúcia Mendonça
Published: October 2022

This present essay is about a quantitative research whose subject is the featuring of the research groups in Brazil, in relation to the connection between woman health and breastfeeding. The purpose was to identify the existing research groups that had breastfeeding as focus of interest, acting on woman health area. From November 2004 to July 2005, a survey based on the census of the National Scientific and Technologic Council from Brazilian Directory, was made by research groups. Using the descriptors woman health and breastfeeding, 12 groups were identified. The survey showed that the distribution of the groups for period was the following: 25% in the 80’s, 50% in the 90’s and 25 % in 2000. In relation to the institutional instance, 58% corresponded to federal institutions, 25% to the state and 17% to the private ones. Among the federative units, 345 of the groups are in São Paulo, 26% in Rio de Janeiro and 8% distributed among Pernambuco, Alagoas, Bahia, Rio Grande do Sul and Sergipe. In relation to the quantitative of researchers, 42% of the groups had 1 to 5, 425 6 to 10, 8% 11 to 20, and 8% more than 20. In relation to the quantitative of students, 25% of the groups had 0 to 5, 50% 6 to 10, 8,3% 11 to 20 and 18,7 more than 20. In relation to the top number of techniques, 84% had 0 to5, 8% 11 to 20 and 8% more than 20. About the number of research lines, 67% has 1 to 5, 25% 6 to 10, 8% 11 to 20. About the linking of the groups to the instruction units or department, it’s shown the following distribution: 25% not specified, 16,9% to social medicine and 8,3% distributed among the departments of Toco-gynecology, Nursery, Maternal-Childish and Psychiatric, Education, Pediatrics, Technologic Institute and research, Milk Bank and sector of Pharmacology and Conduct / Behavior. Analyzing the focus, 37% emphasized Collective Health , 27% Children Health, 8% Biology, 8% Woman Health, 7% Adult Health, 5% Mental Health, 3% Dental Health, and 2% Education. The conclusion is: there is scarcity of Research Groups about breastfeeding; after all, the woman health hasn’t had exclusive attention, with the predominance of the children health. KEY WORDS: Breastfeeding, Woman Health.
The proposition of the concept of Nursing virtual community – a review study
Authors: Brandão Marcos Antônio Gomes , Peixoto Mauricio Abreu Pinto , Ferraz Viviane Modesto
Published: October 2022

The authors of the paper propose a concept to nursing virtual community based in concepts about communities and virtual communities. In this paper, some aspects that have influenced the creation of a concept to nursing virtual community are also presented, especially, the social interaction, collaboration and cooperation in virtual communities concepts. The authors highlight some issues about virtual groups and nursing virtual communities in Brazil, and discuss specific variables that interfere on interaction inside of community, such as, strategies used to establish or maintain relationship in virtual environments, and interactive and communicational processes rules and philosophies on virtual environment internet-based.
Legislative Support for the Unity of Executive Bodies in the Context of Systems Theory
Authors: Rossinskiy B. V.
Published: October 2022

The paper argues for the need for a systematic approach to the totality of executive bodies at different levels. The paper determines inevitability of the spread of the postulates of general systems theory, in particular the system principles of conjugation, ingression and monocentrism over them. The author analyzed the norms of Russian legislation contributing to the implementation of these principles and aimed at achieving the unity of executive bodies. Special attention is paid in the paper to the analysis of the constitutional provision that local self-government bodies and state authorities are part of a single system of public power. It is noted that this provision has led to the emergence of a new architecture of the public administration system, including an intermediate link between state bodies and territorial entities of the country and their population. It is argued that the formation of such an intermediate link — local self-government — from the standpoint of systems theory is nothing more than the implementation of system principles in the practice of public administration. The author examines the monocentrism development in public administration. It has resulted in the strengthening of trends towards the general centralization of the executive system in the Russian Federation under the leadership of the President of the Russian Federation, and it is proved that this contributes to further strengthening of the unity of executive bodies. It is concluded that the current Russian legislation as a whole ensures the achievement of a sufficient level of unity of the bodies under consideration.
«Green» Financing and «Green» Budget in the Russian Federation
Authors: Boltinova O. V.
Published: October 2022

The paper discusses «green» financing and its terminology. The author analyzes the purpose and objectives of «green» projects, historical aspects of their formation and development and explains their varieties in the Russian Federation. Greening of the Russian economy and financial system is considered as one of the most important directions of the state policy until 2025. The author focuses on financial instruments of «green» finance. It is noted that in 2019 for the first time the Russian Federation was singled out among the countries that issued «green» bonds (climate bonds or sustainable bonds). The author considers «green» budgeting in the budget process and elucidates analytical documents and methodological guidelines for drawing up a «green» budget. The paper highlights the experience of the «green» budget in France. The year 2021 for France was the first year of the implementation of the «green» budget, where budget revenues and expenditures were assessed taking into account their impact on the environment. It is noted that the «green» budget in France means, in fact, a new classification of budget expenditures, which is based on the criterion of environmental impact. Also the paper provides the definition of state resources for environmental development. Several aspects of the impact on the «green» state budget are highlighted, which include the fight against climate change, prevention of natural risks, effective management of water resources, combating environmental pollution, as well as the protection of natural, forest and agricultural territories. In the Russian Federation, «green» finance is only at the stage of its formation and state support for «green» investment is needed.
Class Action Lawsuits in Competition Cases in the US and UK and Prospects for their Development in Russia
Authors: Istomin V. G.
Published: October 2022

The need to protect the rights and legitimate interests of entities affected by anti-competitive actions, to compensate for the losses caused to them, as well as to suppress illegal behavior in relation to a wide range of people, requires states to search for various measures to counteract such abuse by companies of their market power. One possible measure is class action, which is currently used in the US and UK as an effective mechanism to protect businesses and consumers from anti-competitive behavior. Taking into account the fact that the procedure of group proceedings has been developed in modern Russian legislation, the experience of implementing the relevant norms in other countries is of undoubted interest for study. The author analyzes the provisions on class actions contained in the legislation of the United States and Great Britain, the practice of their application in the field of competition protection, as well as the prospects for class proceedings in Russia. The conclusion is made about the insufficiency of legally fixed economic incentives for filing class actions, which may prevent the widespread use of this institution in Russian practice, including in antimonopoly disputes.
Subject Matter of Contract of Services for Maintaining Reserve Heat Capacity
Authors: Khamidullin M. T.
Published: October 2022

In the paper, the author analyzes the subject matter of the contract for the provision of services to maintain reserve heat capacity. The author notes that the contract for the provision of services to maintain reserve heat capacity is almost the only contract in the field of heat supply, the definition of which is not in the legislation. At the same time, this problem is not covered in the legal literature. To disclose the subject of the contract under study, the author refers to such legal categories as «power», «heat capacity», «reservation (booking)", «reserve heat capacity». The paper presents the provisions of the doctrine and judicial practice on the nature of power in the energy sector, offers the author’s own point of view on the essence of reservation (reservation) as a legal category. On the basis of the study, the author formulates the definition of the contract in question, which is absent in the legislation, and determines its place in the system of civil law contracts as a non-defined contract.
Rasgos de los precedentes teológicos medievales de las narraciones modernas y contemporáneas del estado de naturaleza
Authors: Lázaro Pulido Manuel
Published: October 2022

La teorización moderna del estado de naturaleza, su narrativa secular, no solo ha sido crucial para el desarrollo de las teorizaciones del Estado moderno; incluso se pueden observar sus derivadas en las formulaciones liberales como la Teoría de la justicia de John Rawls y su posición original dentro de una teoría contractualista. Efectivamente, la teorización contemporánea de las posiciones contractualistas no puede sustraerse de un diálogo con las teorías modernas que van de Locke a Kant. Pero sería un error, propio de la posición deformante de cierta lectura de la modernidad, no preguntarse por la naturaleza teológica de dicha narrativa. Intentaremos rastrear sus raíces medievales, especialmente desde la antropología teológica medieval, haciendo hincapié en la formulación franciscana
Del orgullo individual a la simpatía cívica: Emociones para una convivencia virtuosa en el pensamiento de David Hume
Authors: Delgado Rojas Jesús Ignacio
Published: October 2022

El sentido de la propia valía es uno de los caracteres morales más indispensables que configuran la personalidad de un individuo. En este trabajo retomo la idea del orgullo natural en el correcto sentido que le otorgó David Hume. Se recorre el camino que muestra cómo el orgullo, con su componente individual de autoestima y su elemento social de reconocimiento, genera consecuencias positivas para los lazos humanos que conforman el tejido social. El mecanismo que explica este funcionamiento es la psicología de la simpatía que termina por abarcar las relaciones de la sociedad. La pasión del orgullo y la simpatía como dispositivo de comunicación de emociones entre semejantes tienen efectos beneficiosos para la cohesión de nuestra vida en comunidad
La normalización de Vox y su ideología del día a día. Nacionalismo banal y cotidianeidad desbordada
Authors: Corrochano David H.
Published: October 2022

Este artículo comprende cómo un partido político construye una ideología del día a día, es decir, una identidad y un relato para poder mantener conversaciones cara a cara, donde desplegar las doctrinas del partido de modo normalizado, implícito y aplicadas a una cotidianeidad interpretada de modo acorde a esas doctrinas. Este proceso, que se efectúa en el contexto de la guerra cultural, lo analizamos a través de la propaganda en YouTube de Vox para comprender cómo ha logrado trasladar su alarma patriótica a un discurso sobre el desborde de la cotidianidad explicable por el nacionalismo banal. Para ello, realiza una deixis patriótica por la que construye un nosotros portador del sentido común frente a un ellos, inserta a estos sujetos en una metáfora bélica y otra familiar que les dota de sentido, y muestra que ese relato explica y puede desplegarse en situaciones cara a cara porque resulta realista, presentable y ancla relaciones. Lo que hace que la ideología de Vox haya sido normalizada en la conversación, al menos en términos de la propaganda y en determinadas regiones de conducta.
Escenarios para la reforma del sistema de financiación de las comunidades autónomas en España: Entre los principios técnicos y las preferencias políticas
Authors: Bosch Nuria , Vilalta Maite , Lago Ignacio
Published: October 2022

En este artículo se examina el sistema de financiación de las comunidades autónomas en España desde la economía y la ciencia política. Tras definir los principios básicos del federalismo fiscal y su relación con las preferencias políticas de los ciudadanos, discutimos los problemas del modelo vigente y sus posibles reformas en tres escenarios de federalismo débil, moderado y potente. El sistema de financiación autonómico en España se compara con el de cuatro países federales: Alemania, Canadá, EE. UU. y Suiza. Se adopta una perspectiva propositiva dirigida a la formulación de recomendaciones políticas.
Geçmişte Bir Mekân Günümüzde Bir Anı: Sözlü Tarihle 1990’lı Yılların Eskişehir’inde Sinemaya Gitme Deneyimi Üzerine Bir İnceleme
Authors: ÖZKAR Melek
Published: October 2022

1895 yılından günümüze gelinceye dek birçok kişi sinemaya gitme deneyimi yaşamıştır. Bu deneyimin bazen anlık kararlara bazen de bir programa bağlı kalınarak yaşandığı söylenebilir. Sinemaya gitme deneyimi günlere, haftalara, aylara ve özellikle yıllara göre değişkenlik gösterir. Bu değişken yapı, sinemaya gitmeye dair hafızalarda yer alan anıları ortaya çıkarabilecek sözlü tarih çalışması ile anlaşılabilir. Sözlü tarih yöntemi çerçevesinde gerçekleştirilen bu çalışmanın amacı 1990’lı yıllarda Eskişehir’de sinemaya gitme deneyimlerine sahip olan kişilerin anılarına ulaşılarak o dönemde sinema mekânlarına yönelik oluşan algıları ve sinemaya gitme deneyimlerini ortaya koymaktır. Çalışmanın problemi ise bu deneyimlerin daha çok hangi ortak temalar çerçevesinde yaşandığını belirlemektir. Çalışma, 1990’lı yıllarda Eskişehir’de sinemaya gitme deneyiminin ne şekilde yaşandığını bu deneyimi yaşayan kişilerin söylemlerinden yola çıkarak aktarması ve Eskişehir’e yönelik böyle bir çalışmaya daha önce yer verilmemiş olması bakımından önemlidir. Çalışmada toplam 24 kişiyle görüşülmüş, bu kişilerin o yıllardaki sinemaya gitme deneyimleri irdelenmiştir. İnceleme sonucu, Eskişehir’de günümüzde var olmayan ancak o yıllara imzasını atan, sosyalleşmenin öncüsü olan önemli sinema mekânlarının bulunduğu ve 1990’lı yıllara özgü durumların sinemaya gitmeye yönelik oluşan anılarda yer aldığı anlaşılmıştır.
Assessing Indonesia’s Environmental Laws Pertaining to the Abatement of Marine Plastic Pollution: A Euphemism?
Authors: Tan David
Published: October 2022

The predominance of irresponsible and unsustainable plastic usage in Indonesia poses an urgent and alarming danger to the ecosystem. This paper discussed the legislative and regulatory mechanism in place in Indonesia to manage marine plastic pollution, the limitations and obstacles it faces, and the possibility of remedies being implemented to resolve Indonesia's marine plastic pollution predicament. The ecological approach, sustainable development goals, human right to a healthy environment, and sociopolitical context will all be used to advise this research. The findings demonstrate both top-down and bottom-up initiatives to marine plastic pollution law and regulations are ineffectual. If not adequately regulated, the government, political, and economic structural proclivities would most likely favor economic expansion at the expense of appropriate protection of the environment. Indonesia has to consider not just more comprehensive law and regulation to handle the complex concerns of marine plastic pollution, but it also sought to acknowledge other drivers that hamper the success of efforts to conserve the marine ecosystem. As a result, it is suggested that Indonesia initially focus on short-term measures prior to progressing on to long-term remedies, with effective cohesion across all approaches and collaboration with all involved parties.
A New 4-DOF Robot for Rehabilitation of Knee and Ankle-Foot Complex: Simulation and Experiment
Authors: Alipour Afshin , Mahjoob Mohammad , Nazarian Ara
Published: October 2022

Stationary robotic trainers are lower limb rehab robots which often incorporate an exoskeleton attached to a stationary base. The aim is to recover range of motion, increase muscles strength and reduce joint stiffness. The issue observed in the stationery trainers which involve knee and ankle-foot complex joints simultaneously is that they restrict the natural motion of ankle-foot in rehab trainings due to the insufficient Degrees of Freedom (DOFs) of these trainers. This restriction makes the joints deviate from their natural motion patterns, exerting potentially harmful forces and strain the joints. In this work, we propose a new stationary knee-ankle-foot rehab robot with all necessary DOFs including knee flexion/extension in addition to ankle plantarflexion/dorsiflexion, ankle-foot abduction-adduction and foot supination/pronation. Axes of motions are determined based on the kinematics of the joints. A typical rehab training exercise has been considered to evaluate the system performance. The chosen training (i.e., passive assistance) was first implemented in simulation to synthesize the control loop and to extract the parameters required for selecting the robot’s components. The robot was then fabricated and tested on a healthy subject. Results showed that all natural motions of the ankle-foot complex were generated during the training. Therefore, the proposed system fulfils the desired aim properly, so that it can be utilized in the design of rehab robots.
Design and Fabrication of a Low-Cost System for Smart Home Applications
Authors: Sahrab Ammar Ali , Marhoon Hamzah M.
Published: October 2022

Smart systems and security got impressive attention and development in recent years, which have been appeared in the terms of smart homes, intelligent security, and the Internet of Things (IoT). Home automation comprises the controlling of the electrical appliances in the home wirelessly or automatically. Many different integrated circuits, sensors, modules, and embedded systems are available to be compatible to integrate with smart homes. In order to apply the concept of smart homes, many issues should be considered like as providing a user-friendly, reliable, secure, and cost-effective. In this paper, an effective and low-cost smart home system is designed and implemented based on the Arduino microcontroller boards with its compatible modules. The proposed work employed many types of sensors to carry out the tasks for the smart home for a couple of the essential segments, the first one is home security and the latter one is home automation. The antitheft home segment is based on the laser source directed on the light-dependent resistor and infrared sensor; once the thief tries to cut the laser or passes beside the sensor, the alarm will be switched on. The later segment aims to detect the fire occurring by the means of the flame sensor, gas leakage detection by the MQ-05 sensor, servo motor to opening/closing the garage door, LCD to display the status of the all-utilised sensors, and finally, the Bluetooth module to controlling the garage door wirelessly. To increase the system performance and reliability the Arduino Nano and the Arduino Leonardo board are utilised.
Inflammation on the crossword of Parkinson’s disease and COVID-19
Authors: Basu Barnali Ray , Pal Randrita
Published: October 2022

Worldwide pandemic of COVID-19 has resulted in various physiological manifestations mainly affecting the respiratory system and also the nervous system. Inflammation, a hallmark symptom of diseases links both COVID-19 and neurodegenerative disorders. COVID-19 infection resulted in immune responses like cytokine and chemokine production, and even cytokine storms (in severe cases), which lead to inflammation. Parkinson’s Disease (PD), characterised by motor difficulties is mainly due to α-synuclein aggregates and the disease is known to have dual instigations. In one way the central inflammation caused due to tissue injury, glial cell dysfunction and proinflammatory molecule production, resulting in Blood Brain Barrier leakage and in another way peripheral inflammation occurs due to altered gut microbiome after pathogen attack, producing inflammatory mediators. Inflammation being a potential threat for onset and progression of PD is the major concern of this article. Immediate effect of COVID-19 might be respiratory ailment and hypoxia might contribute to inflammation but the long-lasting effects are uncertain which might increase neurodegenerative diseases in future. Anti-inflammatory therapeutic interventions have already shown varied results for COVID-19 infections of various stages but its impact on PD is yet to be studied. Here, we have elucidated the role of inflammation in the pathophysiology of PD and developing new therapeutic approach by targeting the inflammatory cascade.
A study on trigeminal nerve: Does superior cerebellar artery causes trigeminal neuralgia
Authors: Gaydhanker Anuradha Prasanna , Gaydhanker Prasanna Shravan
Published: October 2022

Our brain is the most complex organ in our body which conducts various complex functions and this level of complexity is operated by different structures of the brain. The complexity of relaying information between brain and different parts of the body is conducted by 12 pairs of cranial nerves. Out of 12 pairs of cranial nerves, the most complex and largest nerve is know as trigeminal nerve which is responsible for sensation of face and motor functions such as biting and chewing. Sometimes due to offendation of this nerve typically by Superior Cerebellar Artery leads to most excruciating painful disorder humanity have ever witnessed.

: A systemic self-study was planned to determine and review with proper enlightenment on the existing facts to find the root sources of trigeminal neuralgia.

This article discussed and focused on the exact cause of trigeminal neuralgia it’s association with Superior Cerebellar Artery along with descriptive analysis on the available treatments for this disorder.

We concluded with the fact that based on our thorough review and analysis Superior Cerebellar Artery is the main artery which typically causes world’s most excruciating painful Suicide Disease.
ABO blood group relationship with COVID-19 occurrence and severity
Authors: Yadav Anurag , Mala Ravi D , Besati Sri Hari Yadav , Padmasree D , Manaswini Golla Anmol , Kumar L G Nanda
Published: October 2022

Study aimed to assess the relation between the ABO blood group and occurrence of COVID-19 and severity.

This was a single centric retrospective study conducted at the MNR Medical College & Hospital among the patients admitted for COVID-19 infections during the July 25 to 30 October 2020. All the patients who were tested COVID-19 positive and the blood type recorded in the health care record were included in present study. The demographics, comorbidities, and the laboratory data of CBC, RBS, liver function test, renal function test, C-reactive protein, serum ferritin and D-dimmer were reviewed.

Total of 365 patients are enrolled in present study (53.2% male and 45.8% female. The blood group of A was common followed with blood group O and group B. 68.5% (n=250) of the patients included had turned to be positive for COVID-19 and 31.5% (n=115) were with negative COVID-19. There was a significant higher odds of the COVID-19 among the blood group A compared to the other blood group type and blood group O had lower odds of the disease. Requirement of ventilator support was significant higher in patients with group A compared to other blood group. In present study, total of 4 patients succumbed to death.

There is presence of higher risk of type A blood group compared to other blood group type with susceptibility for the SARS-CoV (COVID-19) and also the severity of the progression of disease.
Presence of radix entomolaris and paramolaris in primary teeth in children of Garhwa district: A report on two cases
Authors: Kashyap Nilotpol , Patel Soni , Rani Shreya , Singh Nishi , Singh Chitra Ranjan
Published: October 2022

Pediatric dentistry is not only about the hard (Teeth) and soft tissues which are visible and can be treated. There are so many dental anomalies which can not be seen through naked eyes inspite of them being in the oral cavity unnoticed i.e, anomalies of the root.

These anomalies are detected only while patient undergo treatment for the culprit tooth and these anomalies are present adjacent to the tooth or the tooth which undergoes radiographic examination for the diagnosis.

During diagnosis primary molar radiographs shows extra root (Supernumerary root). The normal anatomy of mandibular molars consists of two roots but in rarest of the rare conditions there are three roots called extra roots. When this extra root is present distolingually to the main distal root it is called “Radix Entomolaris” and when it is present mesiobuccally to main mesial root it is called “Paramolaris”. The purpose of this article is to discuss the prevalence, anatomy, classification, clinical and radiographic diagnosis, and significance of supernumerary roots in contemporary clinical pediatric dentistry practice.
Cinobufagin inhibits proliferation and induces apoptosis of hepatocarcinoma cells by activating apoptosis, AKT, and ERK pathways
Authors: Feng Wendong , Zhao Xiaoyan , Yao Qiang , Li Duqiang
Published: October 2022

Cinobufagin is one of the pharmaceutically active ingredients in the parotoid glands of the Chinese toad Bufo bufo gargarizans Cantor. This study was conducted to investigate the effect of cinobufagin on viability, migration, and apoptosis of hepatocellular carcinoma (HCC) cells and its mechanisms. Human HCC cells (HepG2) were treated with cinobufagin and assessed for viability, apoptosis, and migration using CCK-8 assay, flow cytometry, and wound healing assay. The expression of genes related to the p53, AKT, and ERK pathways was detected using RT-PCR and Western blot analysis. Cell viability assays showed that cinobufagin reduced the viability of HepG2 cells in a concentration- and time-dependent manner. Significantly increased apoptosis was detected in cinobufagin-treated cells as compared with non-treated cells. The migration ability of HepG2 cells was significantly reduced after they were exposed to cinobufagin as compared with control. RT-PCR and Western blot analyses showed that the expression levels of p53, caspase-3, and Bax were significantly upregulated, and the expression levels of AKT and ERK were significantly downregulated after cinobufagin treatment. Our data demonstrated that cinobufagin reduces the viability and induces apoptosis of HepG2 cells. The cytotoxicity is likely achieved by upregulating the p53 pathway and downregulating the Akt and ERK pathways.