bluuebunny/crossref_metadata_2025 huggingface dataset:
ELECTROCHEMICAL DETECTION OF ORGANIC AND BIOLOGICAL COMPOUNDS WITH MODIFIED ELECTRODE
Authors:   , Nantaphol Siriwan
Published: November 2023

In this dissertation, analytical method/devices based on electrochemical detection are described for determining the important compounds/biomarkers in pharmaceutical and medical diagnostic applications, which can be separated into five parts. In the first part, electrochemical method for N-acetyl-L-cysteine (NAC) detection in drug formulations was developed using boron doped diamond (BDD) sensor coupled with flow injection analysis (FIA) system. The proposed method offers a linear range of 0.5 − 50 µmol/L, a limit of detection (LOD) of 10 nM, excellent response precision, and high stability. In the second part, an electrochemical cholesterol sensor was developed using silver nanoparticles modified glassy carbon electrode (AgNPs/GCE). Hydrogen peroxide (H2O2) produced from the enzymatic reaction was monitored for indirect cholesterol quantification. AgNPs showed the catalytic activity of H2O2 reduction, with no observed interference from easily oxidizable species. The proposed method displayed wide linear range of 3.87 - 773.40 mg/dL with LOD of 0.99 mg/dL. In the third part, a selective non-enzymatic glucose sensor was successfully developed using bimetallic Pt/Au modified BDD electrode. Pt/Au nanocatalyts possess high electrocatalytic activity for glucose oxidation in physiological conditions. A linear range of 0.01 -7.5 mM and a LOD of 0.01 mM were obtained. In the fourth part, a silver nanoparticle-modified boron-doped diamond (AgNP/BDD) electrode coupled with paper-based analytical devices (PADs) was developed for cholesterol detection. Cholesterol and cholesterol oxidase (ChOx) were directly drop-casted onto the hydrophilic area of PAD followed by monitoring of H2O2 from the enzymatic reaction using chronoamperometry. A linear range and a LOD were obtained at 0.01 - 7 mM and 6.5 uM, respectively. In the final part, the disposable boron doped diamond paste electrodes (BDDPEs) for microfluidic paper-based analytical devices (µPADs) were developed and employed for two applications; the quantitative detection of norepinephrine (NE) and serotonin (5-hydroxytryptamine, 5-HT), and the anodic stripping voltammetry of heavy metals. In case of biological species, the electrochemical paper-based analytical device (ePAD) was capable of simultaneously detecting NE and 5-HT in concentration ranges of 2.5−100 µM and 0.5−7.5 µM, respectively. For heavy metal quantitation, a flow-through µPAD design using square-wave anodic stripping voltammetry (SWASV) to enhance the efficiency of metal deposition was presented, thereby improving the detection sensitivity compared to a static ePAD system. The results demonstrated that all proposed method/sensors provide high sensitivity, selectivity, low cost, and portability.
Essential oils against gastrointestinal nematodes in sheep in vitro and chemical composition of those plants
Authors: Osório Thaís Moreira , Menezes Leonardo de Melo , Martins Anelise Affonso , Schimidt Denise , Pretto Matheus Milani , Rosa Karoline Barcellos da , Souza Velci Queiróz de
Published: November 2023

The present study aimed to evaluate the in vitro potential of aromatic plants Aloysia triphylla (cidró ou erva-luísa), Corymbia citriodora (eucalipto-limão), Lippia alba (falsa-melissa) e Piper gaudichaudianum (pariparoba), in helminths eggs and larvae, determine their main constituents. For this, the essential oils (OEs) of the plants were extracted from leafs, in the clevenger apparatus and to determine the main constituents was carried out the gas chromatography coupled to mass spectrometry. The Egg eclodibility assay (EEA) and Larval development test (DLT) were performed using essential oils at concentrations ranged from 75 at 0.2%. mg.mL, and all tests followed by commercial anthelmintic positive control and negative control distilled water. For EEA, A. triphylla e L. alba OEs demonstred equivalente efficacy to the commercial drug at all concentrations that was tested, while P. gaudichaudianum OE demonstred equivalente efficacy at 15 mg/mL and the C. citriodora OE at 10 mg/mL. About DLT, all concentratios of the studied essential oils were effective as the comercial drug results in this test. The dominant constituent in OEs were: geraniale (A. triphylla), citronellal (L. alba), linalool (L. alba) and α-humuleno (P. gaudichaudianum). Based on the results presented here, the OEs present potential for use as natural anthelmintics for the treatment of endoparasitosis in sheep.
New paper: theropod bite marks on Morrison sauropod bones
Authors: Wedel Matt
Published: November 2023

Distal end of MWC 4011, an ischium of  Apatosaurus louisae  that got munched on by a large theropod, probably  Allosaurus  or  Ceratosaurus  . On display at Dinosaur Journey in Fruita, Colorado. New paper out today in PeerJ: Lei R, Tschopp E, Hendrickx C, Wedel MJ, Norell M, Hone DWE. 2023. Bite and tooth marks on sauropod dinosaurs from the Morrison Formation.
Pelaksanaan Literasi Sekolah Sebagai Peningkatan Sumber Daya Manusia di SMAN 1 Puri
Authors: Roza Azzukhrufi Jaya , Zainuddin Ammar , Mabrur Moh Ali
Published: November 2023

Management of educational human resources as the most strategic effort in maximizing the management of an educational institution. The quality of human resources is closely related to literacy, literacy is related to science, science is related to understanding and intelligence. The low mindset regarding the importance of literacy culture in society makes the quality of human resources stagnate at a low level, this is based on the PISA and UNESCO assessments. Literacy is an essential element that must be instilled in human resources today. The purpose of this study is to determine the management of human resources at SMAN 1 Puri. This research uses a case study approach with a qualitative research type, by placing an object into a case in the research. While collecting research data with observation methods, interview methods, and documentation.  The analysis flow uses an interactive analysis model, by carrying out four stages, data collection, data reduction, data presentation, and deduction. The result of this study is that the management of human resources at SMAN 1 Puri is carried out by following the management function, namely implementing a planning, organizing, realizing and supervising, which is the main point in the management of human resources is the implementation of literacy culture, Such as planning an annual literacy program, training and self-development, writing classes, discussions of various genres of literary works or scientific papers, and holding a literacy camp for 40 days.
Pengaruh Beban Kerja Dan Stres Kerja Terhadap Kinerja Pegawai Yang Dimediasi Kepuasan Kerja Studi Empiris Pada Pegawai Satuan Polisi Pamong Praja Provinsi Kalimantan Timur
Authors: Dony Muslim  , Zainal Ilmi  , Irwansyah
Published: November 2023

Penelitian ini bertujuan untuk melakukan analisis mengenai dampak Beban Kerja dan Stres Kerja terhadap Kinerja Pegawai yang dihubungkan oleh variabel Mediasi Kepuasan Kerja. Studi empiris ini dilakukan pada Pegawai Satuan Polisi Pamong Praja Provinsi Kalimantan Timur, suatu topik yang memiliki relevansi yang signifikan dalam ranah manajemen sumber daya manusia. Metodologi yang diterapkan dalam penelitian ini adalah kuantitatif deskriptif, dengan pengumpulan data dilakukan melalui kuesioner menggunakan metode sampling jenuh pada 69 responden. Data yang terhimpun kemudian dianalisis dengan menerapkan metode Persamaan Struktural Partial Least Squares (SEM PLS). Hasil analisis data menunjukkan bahwa Beban Kerja dan Stres Kerja memberikan dampak negatif terhadap Kepuasan Kerja dan Kinerja Pegawai. Selain itu, Kepuasan Kerja teridentifikasi sebagai mediator yang mampu menghubungkan antara Beban Kerja dan Stres Kerja dengan Kinerja Pegawai.
The Big Five Personality Dimensions in Large-Scale Surveys: An Overview of 25 German Data Sets for Personality Research
Authors: Rammstedt Beatrice , Roemer Lena , Mutschler Julie , Lechner Clemens
Published: November 2023

In recent decades, the number of large-scale surveys that have included measures of the Big Five personality traits in their standard questionnaires has grown sharply both in Germany and internationally. Consequently, a vast, heterogeneous, high-quality data base is now readily available to personality psychologists for secondary analyses. In this paper, we provide an overview of 25 public large-scale surveys assessing the Big Five. Our aim is to increase researchers’ awareness of the availability and analytical potential of these data, and ultimately to increase their reuse. We restricted our selection to surveys of the adult population, conducted in Germany, based on probabilistic samples with a minimum sample size of 1,500 respondents, and assessing all Big Five dimensions with a validated Big Five instrument. We describe the study designs, the measures used to assess the Big Five, and the research potential of these valuable data.
학습분석 실천과 윤리 (Practicing Learning Analytics and Ethics)
Authors: Lee Hakeoung , Kwon Hyun G
Published: November 2023

이 챕터에서는 학습분석의 전반적인 실행 과정과 윤리적 책임을 안내하고자 한다. 개요는 다음과 같다. 첫째, 학습분석을 시작하기 위한 기본적인 환경설정부터 데이터 종류별 학습분석 실행 절차와 활용 사례를 소개하였다. 둘째, 학습분석 시스템을 도입할 때의 개인 정보 남용 및 오용에 대한 위험성과 학습분석 시스템을 구성하는 참여자들간의 신뢰 관계, 그리고 행위주체성을 고려해야 함을 강조하였다. 이 챕터를 통해 교육학 전공자들이 학습분석의 실행 과정을 더 쉽게 이해하고 학습분석의 이론과 실천 간의 간극을 좁힐 수 있기를 기대한다.
Offshoring Asylum the Italian Way
Authors: Piccoli Lorenzo
Published: November 2023

On 6 November 2023, the Italian Prime Minister Giorgia Meloni and the Prime Minister of Albania Edi Rama announced the signing of the Agreement for Strengthening of Collaboration in the Field of Migration. The agreement proposes a relocation of asylum seekers who are rescued at sea by Italian vessels to two centres that would be built in Albania and could host up to 3’000 people. This is part of a broader trend whereby European governments seek to move asylum procedures outside of their territory. At the same time, the agreement contains some innovations compared to previous proposals. Indeed, this move has been hailed as a “model and example for other collaboration agreements of this kind” by the Italian Prime Minister. This article contends that this is unlikely to be the case: the legality and feasibility of offshoring asylum procedures remain dubious at best.
#MPIL100 – Beginn einer Spurensuche
Authors: Glahé Philipp , Kemmerer Alexandra
Published: November 2023

Das Max-Planck-Institut für ausländisches öffentliches Recht und Völkerrecht (MPIL) kann 2024 auf eine 100-jährige Geschichte zurückblicken. Grund genug, die historische Entwicklung des Instituts und seinen Beitrag in Wissenschaft und Praxis zu erinnern und zu reflektieren.
The Rule of Arbitrariness as the New Constitutional Order in Turkey
Authors: Balamir Coşkun Gülçin , Tombuş Ertuğ
Published: November 2023

Nearly two weeks after the 100th-anniversary celebrations of the Republic, Turkey's constitutional order faced one of the most significant judicial crises in its history when the Court of Cassation, the highest court of ordinary jurisdiction, and the Turkish Constitutional Court (TCC) clashed over the fate of imprisoned opposition politician Can Atalay. How should we interpret this constitutional crisis? Is it the death of constitutionalism in Turkey? Is it an attempt to test the boundaries of legitimacy before establishing the rules of a new constitutional order?
MİMARLIKTA SINIRLARIN TEKİNSİZLİK OLUŞTURMAYA ETKİSİ: DOLAPDERE ÖRNEĞİ
Authors: YÜCEL Aslı , AYDIN Enes
Published: November 2023

Mimarlığın temel amacı olan mekan üretmede vazgeçilmez bir rol üstlenen sınırlar; mimarlığın ilk zamanlarında korunma amacıyla ortaya çıkmış olup varlıklarını hep sürdürmüşlerdir. Günümüzde keskin sınırlarla çevrelenmiş kentlerin yüzleşmekte olduğu aşırı nüfus, artan güvenlik ihtiyacı ve zayıflayan kamusallık, ‘tekinsizlik’ kavramını beraberinde getirmektedir. Bu çalışmada, ‘kent’, sınır ve tekinsizliğin çarpışmalarının sahnesi olarak görülmüş, kentte kaotik bir hal alan mekansal deneyimlerin sınırlar ve tekinsizlik üzerinden irdelenmesi amaçlanmıştır. Üç aşamalı bir yöntem izlenmiş; literatür araştırması ile sınır ve tekinsizlik kavramları incelenmiş, Dolapdere semtinde bir alan çalışması yapılmış ve alan çalışmasından edinilenler üzerinden bir anket çalışması yürütülmüştür. 19. yüzyıldan beri farklı kesimler barındıran, konut ve küçük ölçekli ticari birimlerin yoğunlukta bulunduğu Dolapdere, son yıllarda bölgeye getirilen oteller ve sanat kurumları yoluyla geçirdiği ‘soylulaştırma’ sürecinin de etkisiyle farklı sınır durumların gözlenebileceği kentsel bir mekan olduğundan çalışma kapsamına alınmıştır. Sınır ve tekinsizlik, öznel ve yoruma açık kavramlar olduklarından net bir sonuca ulaşmaya çalışmadan bu olguların kentsel deneyime etkilerine dair bir yorum getirmek hedeflenmiştir. Çalışma sonucunda sınırların var olma sebepleri, geçirgenlikleri, keskin-bulanık olma halleri gibi özellikleriyle tekinsizlik hissi oluşturabildikleri, ancak her sınırın tekinsizlik meydana getirmediği görülmüştür. Sınır ile tekinsizlik birbiriyle oldukça ilişkili kavramlar olup bu araştırmayla kentsel deneyim üzerindeki etkilerinin önemine dikkat çekmek hedeflenmektedir.
ĐÁNH GIÁ CHỈ SỐ HBcrAg Ở NGƯỜI BỆNH VIÊM GAN VIRUS B MẠN TÍNH ĐANG ĐIỀU TRỊ THUỐC NUCLEOT(s)IDE ANALOGUES (NAs) TẠI BỆNH VIỆN BỆNH NHIỆT ĐỚI TRUNG ƯƠNG
Authors: Phạm Thị Thu Hương , Lê Nguyễn Minh Hoa , Nguyễn Thị Vân Hà , Vũ Thị Thu Hương , Phạm Ngọc Thạch
Published: November 2023

Mục tiêu: Mô tả đặc điểm chỉ số HBcrAg ở người bệnh viêm gan virus B mạn tính đang điều trị thuốcNucleot(s)ide Analogues (NAs) có kết quả xét nghiệm đo tải lượng HBV DNA dưới ngưỡng phát hiện hoặckhông phát hiện được và xác định hệ số tương quan giữa HBcrAg với các dấu ấn khác. Nghiên cứu được tiếnhành từ tháng 11/2022 đến tháng 10/2023 tại Khoa Khám bệnh và Điều trị ngoại trú cơ sở Giải Phóng, Bệnhviện Bệnh Nhiệt đới Trung ương.Phương pháp: Mô tả cắt ngang.Kết quả và kết luận: Nghiên cứu gồm 225 người bệnh viêm gan virus B mạn tính (CHB) đang điều trịthuốc nucleos(t)ide từ 2 - 4 năm đủ tiêu chuẩn vào nghiên cứu. Trung vị nồng độ HBcrAg trong huyết thanh là4,2 logU/ml. Tỷ lệ HBcrAg ≥3 là 76,4%, chiếm khoảng 3/4. Nồng độ HBcrAg có sự khác biệt có ý nghĩa thốngkê theo nồng độ HBsAg (p < 0,001) và theo HBeAg (p < 0,001). Nồng độ HBcrAg có tương quan thuận vớinồng độ HBsAg (r = 0,337, p < 0,001) bất kể tình trạng HBeAg như thế nào. Tuy nhiên, nồng độ HBcrAg chỉcó tương quan thuận với nồng độ HBsAg ở nhóm HBcrAg ≥ 3 log U/ml (r = 0,32, p < 0,001) và nhóm HBsAg>1000 IU/ml (r = 0,272, p = 0,006). Ở nhóm số lượng tiểu cầu giảm, nồng độ HBcrAg và số lượng tiểu cầu cótương quan nghịch ở mức vừa (r = - 0,597, p = 0,031).
HIỆU QUẢ CỦA TIÊM CHỦNG VÀ NGUYÊN TẮC SỬ DỤNG VẮC XIN
Authors: Nguyễn Tuấn Khanh
Published: November 2023

Nhà khoa học Jenner phát minh ra vắc xin vào năm 1796 là một thành tựu Y học vĩ đại của nhân loại. Kể từ khi vắc xin ra đời, loài người đã thực sự có được một loại vũ khí siêu hạng, sắc bén nhất, hữu hiệu nhất để chủ động phòng chống các bệnh truyền nhiễm nguy hiểm.

Vắc xin và tiêm chủng là biện pháp phòng bệnh hiệu quả nhất để làm giảm tỷ lệ mắc bệnh và tỷ lệ tử vong do bệnh truyền nhiễm của nhân loại gây ra.

Khoảng 85% - 95% người được tiêm chủng sẽ sinh ra miễn dịch đặc hiệu bảo vệ cơ thể không bị mắc bệnh. Người được tiêm chủng không bị mắc bệnh sẽ không bị chết hay di chứng do bệnh dịch gây ra. Nhờ có vắc xin, hàng năm trên thế giới đã cứu sống được khoảng 2,5 triệu trẻ em không bị chết do bệnh truyền nhiễm. Vắc xin và tiêm chủng góp phần quan trọng để đạt được mục tiêu thiên niên kỷ của Liên Hợp quốc về giảm tỷ lệ tử vong cho trẻ dưới 5 tuổi trên toàn thế giới.

Và gần đây nhất, đại dịch COVID-19 đã làm hàng trăm triệu người mắc và hàng triệu người chết, nhưng nhờ có vắc xin mà bệnh dịch đã được khống chế.
PHYSICOCHEMICAL AND STRUCTURAL CHARACTERIZATION OF SILICATE GLASSES CONTAINING IRON OXIDES
Authors: Mihailova Irena , Harizanova Ruzha , Tasheva Tina , Dimova Nikoleta , Rüssel Christian
Published: November 2023

The interest in glasses containing iron oxides is determined by the possibility for application in optics, sensors,nanoelectronics, biotechnology and medicine. Subject of the present investigation is the preparation of glasses inthe system 16Na2O/10CaO/(74-x)SiO2/xFe2O3, x = 0, 5, 10 and 15 mol % by applying the traditional melt-quenchingtechnique. X-ray diffraction analysis proves that the materials with up to 15 mol % Fe2O3are amorphous whilefor higher concentrations, the crystallization of magnetite and hematite occurs during melt quenching. For thephysicochemical characterization of the glasses, the density, molar volume and oxygen packing density have beendetermined. The Becke line method has been utilized for the refractive indices measurement. The structural evolutionin dependence of the Fe2O3concentration has been studied by Fourier Transformed Infrared Spectroscopy. The dataobtained from the different methods correlates well and reveals a depolymerization tendency of the silicate networkwith the increasing Fe2O3concentration, i.e. an increase in the number of SiO4tetrahedra with more non-bridgingoxygens as a result of the occurrence of Fe-containing polyhedra in the glass structure.
Nociones de técnica legislativa para uso parlamentario
Authors: García-Escudero Márquez Piedad
Published: November 2023

Sumario: I. CONCEPTO Y FINALIDAD DE LA TÉCNICA LEGISLATIVA.—II. ORIGEN Y EVOLUCIÓN DE LA TÉCNICA LEGISLATIVA.—2.1. Origen anglosajón.—2.2. Técnica legislativa alemana.—2.3. Generalización.—III. LA REDACCIÓN DE LOS PROYECTOS DE LEY.—3.1. Máximas previas para el arte de legislar.—3.2. Órgano competente.—3.2.1. Sistema británico.—3.2.2. Sistema alemán.—3.2.3. Sistema español.—IV. NORMAS DE TÉCNICA LEGISLATIVA.—4.1. Significado.—4.2. Los cuestionarios.—4.3. Las directrices.—4.3.1. Concepto y naturaleza jurídica.—4.3.2. Naturaleza.—4.3.3. Derecho comparado: directrices y manuales.—4.3.4. Las directrices en España.—4.3.4.1. Origen.—4.3.4.2. Directrices existentes.—4.3.4.3. Naturaleza jurídica.—4.3.4.4. Contenido.—V. LA TÉCNICA LEGISLATIVA EN LA TRAMITACIÓN PARLAMENTARIA DE LAS LEYES.—5.1. Importancia.—5.2. Conveniencia de un manual de técnica legislativa para uso parlamentario.—5.2.1. Necesidad de un manual propio.—5.2.2. Aprobación y destinatarios.—5.2.3. Contenido.—5.3. La labor de los asesores parlamentarios en relación con la técnica legislativa.—5.3.1. Importancia.—5.3.2. Ámbito.—5.3.3. El modelo de las Cortes Generales.—VI. PRINCIPIOS Y REGLAS DE TÉCNICA LEGISLATIVA.—6.1. Inserción de la ley en el ordenamiento jurídico.—6.2. Lenguaje legal.—6.3. Contenido de la ley.—6.4. Estructura de la ley.—6.5. Leyes modificativas. Especialidades.—6.6. Sanción y promulgación.—6.7. Publicación.—VII. TÉCNICA LEGISLATIVA E INFORMÁTICA.—7.1. Utilidad de la informática para la técnica legislativa.—7.2. Informatización del manual de técnica legislativa.—7.2.1. Informatización de los procedimientos y de la documentación legislativa.—VIII. BIBLIOGRAFÍA ESPAÑOLA BÁSICA.
USABILITY EVALUATION THROUGH EYE TRACKING: A SYSTEMATIC LITERATURE REVIEW
Authors: MEZURA GODOY CARMEN , SANTIAGO CRUZ GERARDELLI , BENITEZ GUERRERO EDGARD IVAN
Published: November 2023

ABSTRACT:
Usability evaluation is traditionally carried out with techniques such as: questionnaires, think-aloud, cognitive walkthroughs, and heuristics. The research works in this area are significant, they show advances such as improvements to different techniques, new technologies, frameworks, prototypes, and approaches to work on usability. Eye tracking is a data collection technique used in visual research (reading patterns, mental fatigue) and recently in usability studies. In this research work, the result of the systematic review of the literature on the evaluation of the usability of software systems through eye-tracking techniques is presented. The review method allowed the identification of techniques, procedures, tools, and metrics used by researchers to evaluate usability. Similarly, the review allowed us to identify areas of opportunity to evaluate usability considering other usability metrics not yet explored.
Does financial risk tolerance change over time?
Authors: Kuzniak Stephen , Grable John
Published: November 2023

Financial planners work in an environment that requires the documentation of a client’s financial attitudes and preferences. Financial risk tolerance is one such attitudinal construct that is generally required by regulators to be evaluated. While there are numerous commercial and academic products used to assess client risk attitudes, questions have been raised over the past several decades regarding the stability of scores from risk-tolerance tools. Specifically, financial planners, as well as regulators, require evidence documenting to what extent risk tolerance changes over time, and if changes do occur, the variables associated with variability. The purpose of this study was to address these needs. Based on a model that included macroeconomic indicators, biopsychosocial and environmental factors, and measures of social support, it was determined that risk-tolerance attitudes remain generally stable over time. However, there are groups of test takers that exhibit significant shifts in risk tolerance. This article describes some of the variables associated with these score changes, as well as providing financial planning professionals with guidance on how to identify clients who may be prone to shifting their tolerance for financial risk.
Who seeks financial advice?
Authors: Alyousif Maher H. , Kalenkoski Charlene M.
Published: November 2023

The determinants of seeking five types of financial advice are examined and are found to be consistent across the different types of advice. In addition, no significant differences are found among subsamples defined by gender, age, and financial literacy. Income and risk tolerance are related positively to the demand for financial advice and more greatly affect the probability of seeking advice than do other variables. A low perception of financial knowledge, which can be a proxy for self-confidence, and financial fragility decrease the probability of seeking financial advice.
Telemedicina, ya está acá, ¿nosotros dónde estamos?
Authors: Ferreyros Kuppers Javier
Published: November 2023

La Telemedicina es una herramienta moderna que ya se encuentra entre nosotros. Hacemos una revisión sobre algunas aplicaciones actuales y lo que se está haciendo en el Perú. Se analiza si los pediatras, familias y compañías de seguro estamos preparados para estos cambios.
Conceptos Importantes sobre Inmunizaciones
Authors: Verne Martin Eduardo , Ugarte Taboada Claudia
Published: November 2023

Las vacunas son el mejor avance médico de la humanidad por el impacto causado al reducir la mortalidad. En esta revisión se desarrollan conceptos generales sobre inmunizaciones tales como definiciones, cadena de frío, eventos asociados a las vacunas, diferentes esquemas, actual e ideal y el futuro con las nuevas vacunas.
Perfil Clínico y Epidemiológico de Pacientes Pediátricos Diagnosticados con Influenza A H1 N1, Junio - Agosto 2009, Lima - Perú
Authors: Rojas Galarza Raúl , Padilla Ygreda Justo , Lindo Pérez Felipe , Tantaleán Da Fieno José
Published: November 2023

Objetivos: Describir el perfil clínico y epidemiológico de los pacientes atendidos por Influenza A H1 N1 en el Instituto Nacional de Salud del Niño, 2009.

Materiales y Métodos: Estudio descriptivo, retrospectivo. Se revisó los registros de la Oficina de Epidemiología y se contrastó con las historias clínicas de pacientes atendidos en el Instituto Nacional de Salud del Niño por Influenza A H1N1, de junio a agosto del 2009.

Resultados: Se registraron 436 casos. 82%, fueron ambulatorios. El género masculino (55%), el grupo etario de 5 a 15 años (más del 40%) y los mayores de 5 años (70%) fueron los más afectados. Del total hisopados faríngeos realizados (147), (33% de los casos) 67% fueron positivos y la tos fue el signo más frecuente (90%). Entre los niños hospitalizados (73) Asma, Epilepsia, Cardiopatía Congénita y Síndrome de Obstrucción Bronquial (30%) fueron las enfermedades asociadas más frecuentes; en el 30%, se registró la vacuna contra el neumococo y en el 53%, un tiempo de enfermedad de 3 a 7 días. El 27% de los hospitalizados presentó leucopenia, cerca del 75% recibió tratamiento antiviral (Oseltamivir) y el resultado del hisopado faríngeo demoró de 3 a 5 días en el 55%. Fallecieron el 10% de los pacientes con hisopado faríngeo positivo.

Conclusiones: La comorbilidad, sexo masculino y edad entre 5 a 15 años se presentaron en gran porcentaje de los pacientes. La tasa de mortalidad para este grupo estudiado fue del 13%. La vacunación contra el neumococo fue baja en estos pacientes.
Utilidad de la Escala Observacional de Yale como Método de Triaje para Detectar Enfermedad Grave en Lactantes Febriles
Authors: Ochoa Allemant Pedro , Obregón Julca Evelyn , Nuñez del Prado Zora Carbajal Fiorella , Ojeda Nieto María Cristina , Anaya Pajuelo Marcial
Published: November 2023

Objetivos: Evaluar la utilidad de la Escala Observacional de Yale (YOS) como método triaje para detectar enfermedad grave en lactantes febriles.

Materiales y Métodos: Estudio de tipo observacional, prospectivo de corte longitudinal donde se aplicó la YOS a los pacientes febriles de 3 a 24 meses que acudieron a la Emergencia Pediátrica del Hospital Nacional Arzobispo Loayza del 13 de abril al 6 de junio del 2012 antes de la atención médica. Los pacientes hospitalizados fueron seguidos hasta el alta y la confirmación del diagnóstico. Los ambulatorios fueron seguidos vía telefónica por un máximo de 5 días para observar su evolución.

Resultados: Se incluyeron 61 pacientes de los cuales 30 (49%) presentaban aspecto sano, 21 (35%) aspecto enfermo y 10 (16%) aspecto muy enfermo. Solo 10 desarrollaron enfermedad grave, 9 (90%) de ellos presentaron un puntaje ≥16. La media del puntaje de YOS para enfermedad grave es de 17, significativamente mayor (p= 0,007) respecto a los que no la desarrollaron. Para un punto de corte de 10, se encontró una sensibilidad del 100%, especificidad del 59%, VPP del 32%, VPN del 100%, LR+ de 2,43 y LR- de 0. Para 16 puntos, se encontró una sensibilidad del 90%, especificidad del 98%, VPP del 90%, VPN del 98%, LR+ de 45,9 y LR- de 0,1. El área bajo la curva fue de 0,982.

Conclusiones: El presente estudio demostró el potencial uso de la Escala Observacional de Yale como método de triaje para detectar enfermedad grave en lactantes febriles de 3 a 24 meses debido a que es simple, reproducible, costo-efectiva y altamente sensible.
Ibn Salam Al-Herawi's Contributions To Islamic Economic Thought: A Comprehensive Analysis Of His Book 'Al-Amwal' And Its Implications For Contemporary Discourse
Authors: Abdulbasir Azizi  , Habiburrahman Rizapoor
Published: November 2023

This study aims to comprehensively examine the influential contributions of Ibn Salam Al-Herawi in shaping the Islamic economy during the medieval era through his seminal work, the book "Al-Amwal." By employing an analytical and descriptive approach, this research delves into Ibn Salam Al-Herawi's profound impact on the foundations and evolution of Islamic economic thought. Through a critical evaluation of primary sources, including "Al-Amwal," historical records, and scholarly commentaries, this study dissects his treatises on economic principles, shedding light on his distinctive perspectives regarding trade, finance, wealth distribution, and ethical considerations within the framework of Islamic economics. The findings of this research underscore the profound influence of Ibn Salam Al-Herawi's innovative ideas as expressed in "Al-Amwal." His work exhibits unique characteristics and specialties not found in other writings on Islamic finance. However, alongside these positive aspects, critiques of Ibn Salam's "Kitab Al-Amwal" have also emerged. In conclusion, this study establishes Ibn Salam Al-Herawi's pivotal role in shaping Islamic economic thought. His insights and perspectives continue to resonate in contemporary discussions on Islamic economics. By emphasizing ethical considerations, equitable trade practices, and just wealth distribution, Ibn Salam underscores the crucial alignment between economic activities and moral values. This alignment highlights the inherent compatibility of Islamic teachings with economic principles, thereby contributing to the broader discourse on the intersection of ethics and economics.
Almost balancers, almost cobalancers, almost Lucas-balancers and almost Lucas-cobalancers
Authors:   Bursa Uludag University, Tekcan Ahmet , Türkmen Esra Zeynep ,   Bursa Uludag University
Published: November 2023

In this work, the general terms of almost balancers, almost cobalancers, almost Lucas-balancers and almost Lucas-cobalancers of first and second type are determined in terms of balancing and Lucas-balancing numbers. Later some relations on all almost balancing numbers and all almost balancers are obtained. Further the general terms of all balancing numbers, Pell numbers and Pell–Lucas number are determined in terms of almost balancers, almost Lucas-balancers, almost cobalancers and almost Lucas-cobalancers of first and second type.
On sums with generalized harmonic numbers via Euler’s transform
Authors:   Department of Mathematics, University of Kocaeli, Ömür Neşe , Koparal Sibel ,   Department of Mathematics, University of Bursa Uludağ, Elkhiri Laid ,   Faculty of Material Sciences, University of Tiaret
Published: November 2023

In this paper, we define the generalized hyperharmonic numbers of order r, H_{n}^{r}\left( \sigma \right) and get some identities involving these numbers by using Euler’s transform.
Neuron-specific RNA-sequencing reveals different regeneration mechanisms in peripheral neurons after nerve injury
Authors: Bolívar S , Sanz E , Ovelleiro D , Zochodne DW , Udina E
Published: November 2023

Peripheral neurons are heterogeneous and functionally diverse, but all share the capability to switch to a pro-regenerative state after nerve injury. Despite the assumption that the injury response is similar among neuronal subtypes, functional recovery may differ. Understanding the distinct intrinsic regenerative properties between neurons may help to improve the quality of regeneration, prioritizing the growth of axon subpopulations to their targets. Here, we present a comparative analysis of regeneration across four key peripheral neuron populations: motoneurons, proprioceptors, cutaneous mechanoreceptors, and nociceptors. Using Cre/Ai9 mice that allow fluorescent labelling of neuronal subtypes, we found that nociceptors showed the greater regeeneration after a sciatic crush, followed by motoneurons, mechanoreceptors and, finally, proprioceptors. By breeding these Cre mice with Ribotag mice, we isolated specific translatomes and defined the regenerative response of these neuronal subtypes after axotomy. Only 20% of the regulated genes were common, revealing a diverse response to injury among neurons, which was also supported by the differential influence of neurotrophins among neuron subtypes. Among differentially regulated genes, we proposed MED12 as a specific regulator of the regeneration of proprioceptors. Altogether, we demonstrate that the intrinsic regenerative capacity differs between peripheral neuron subtypes, opening the door to selectively modulate these responses.
Post-ejaculatory Inhibition of Female Sexual Drive via Heterogeneous Neuronal Ensembles in the Medial Preoptic Area
Authors: Ishii Kentaro K , Hashikawa Koichi , Chea Jane , Yin Shihan , Fox Rebecca Erin , Kan Suyang , Shah Meha , Zhou Charles , Navarrete Jovana , Murry Alexandria D , Szelenyi Eric R , Golden Sam A , Stuber Garret D
Published: November 2023

Male ejaculation acutely suppresses sexual motivation in male mice. In contrast, relatively little is known about how male ejaculation affects sexual motivation and sexual behavior in female mice. How the brain responds to completion of mating is also unclear. Here, by using self-paced mating assay, we first demonstrate that female mice show decreased sexual motivation acutely after experiencing male ejaculation. By using brain-wide analysis of activity-dependent labeling, we next pinpointed the medial preoptic area as a brain region strongly activated during the post-ejaculatory period. Furthermore, using freely moving
in vivo
calcium imaging to compare neural activity of inhibitory and excitatory neurons in the medial preoptic area, we revealed that a subset of the neurons in this region respond significantly and specifically to male ejaculation but not to female-to-male sniffing or to male mounting. While there were excitatory and inhibitory neurons that showed increased response to male ejaculation, the response magnitude as well as the proportion of neurons responding to the event was significantly larger in the inhibitory neuron population. Next, by unbiased classification of their responses, we also found a subpopulation of neurons that increase their activity late after the onset of male ejaculation. These neurons were all inhibitory indicating that male ejaculation induces a prolonged inhibitory activity in the medial preoptic area. Lastly, we found that chemogenetic activation of medial preoptic area neurons that were active during post-ejaculatory period, but not during appetitive or consummatory periods, were sufficient to suppress female sexual motivation. Together, our data illuminate the importance of medial preoptic area as a brain node which encodes a negative signal that sustains low sexual motivation state after the female mice experience ejaculation.
Osteology of the axial skeleton of Aucasaurus garridoi: phylogenetic and paleobiological inferences
Authors: Baiano Mattia Antonio , Coria Rodolfo , Chiappe Luis M. , Zurriaguz Virginia , Coria Ludmila
Published: November 2023

Aucasaurus garridoi is an abelisaurid theropod from the Anacleto Formation (lower Campanian, Upper Cretaceous) of Patagonia, Argentina. The holotype of Aucasaurus garridoi includes cranial material, axial elements, and almost complete fore- and hind limbs. Here we present a detailed description of the axial skeleton of this taxon, along with some paleobiological and phylogenetic inferences. The presacral elements are somewhat fragmentary, although these show features shared with other abelisaurids. The caudal series, to date the most complete among brachyrostran abelisaurids, shows several autapomorphic features including the presence of pneumatic recesses on the dorsal surface of the anterior caudal neural arches, a tubercle lateral to the prezygapophysis of mid caudal vertebrae, a marked protuberance on the lateral rim of the transverse process of the caudal vertebrae, and the presence of a small ligamentous scar near the anterior edge of the dorsal surface in the anteriormost caudal transverse process. The detailed study of the axial skeleton of Aucasaurus garridoi has also allowed us to identify characters that could be useful for future studies attempting to resolve the internal phylogenetic relationships of Abelisauridae. Computed tomography scans of some caudal vertebrae show pneumatic traits in neural arches and centra, and thus the first reported case for an abelisaurid taxon. Moreover, some osteological correlates of soft tissues present in Aucasaurus and other abelisaurids, especially derived brachyrostrans, underscore a previously proposed increase in axial rigidity within Abelisauridae.
Bite and tooth marks on sauropod dinosaurs from the Morrison Formation
Authors: Lei Roberto , Tschopp Emanuel , Hendrickx Christophe , Wedel Mathew J. , Norell Mark , Hone David W.E.
Published: November 2023

Tooth-marked bones provide important evidence for feeding choices made by extinct carnivorous animals. In the case of the dinosaurs, most bite traces are attributed to the large and robust osteophagous tyrannosaurs, but those of other large carnivores remain underreported. Here we report on an extensive survey of the literature and some fossil collections cataloging a large number of sauropod bones (68) from the Upper Jurassic Morrison Formation of the USA that bear bite traces that can be attributed to theropods. We find that such bites on large sauropods, although less common than in tyrannosaur-dominated faunas, are known in large numbers from the Morrison Formation, and that none of the observed traces showed evidence of healing. The presence of tooth wear in non-tyrannosaur theropods further shows that they were biting into bone, but it remains difficult to assign individual bite traces to theropod taxa in the presence of multiple credible candidate biters. The widespread occurrence of bite traces without evidence of perimortem bites or healed bite traces, and of theropod tooth wear in Morrison Formation taxa suggests preferential feeding by theropods on juvenile sauropods, and likely scavenging of large-sized sauropod carcasses.
Temporal bright light at low frequency retards lens-induced myopia in guinea pigs
Authors: Deng Baodi , Li Wentao , Chen Ziping , Zeng Junwen , Zhao Feng
Published: November 2023

Purpose

Bright light conditions are supposed to curb eye growth in animals with experimental myopia. Here we investigated the effects of temporal bright light at very low frequencies exposures on lens-induced myopia (LIM) progression.

Methods

Myopia was induced by application of −6.00 D lenses over the right eye of guinea pigs. They were randomly divided into four groups based on exposure to different lighting conditions: constant low illumination (CLI; 300 lux), constant high illumination (CHI; 8,000 lux), very low frequency light (vLFL; 300/8,000 lux, 10 min/c), and low frequency light (LFL; 300/8,000 lux, 20 s/c). Refraction and ocular dimensions were measured per week. Changes in ocular dimensions and refractions were analyzed by paired t-tests, and differences among the groups were analyzed by one-way ANOVA.

Results

Significant myopic shifts in refractive error were induced in lens-treated eyes compared with contralateral eyes in all groups after 3 weeks (all P < 0.05). Both CHI and LFL conditions exhibited a significantly less refractive shift of LIM eyes than CLI and vLFL conditions (P < 0.05). However, only LFL conditions showed significantly less overall myopic shift and axial elongation than CLI and vLFL conditions (both P < 0.05). The decrease in refractive error of both eyes correlated significantly with axial elongation in all groups (P < 0.001), except contralateral eyes in the CHI group (P = 0.231). LFL condition significantly slacked lens thickening in the contralateral eyes.

Conclusions

Temporal bright light at low temporal frequency (0.05 Hz) appears to effectively inhibit LIM progression. Further research is needed to determine the safety and the potential mechanism of temporal bright light in myopic progression.
Sustainable Strategies in Business Area Courses at UNIFAAT University Centre, Atibaia, São Paulo, Brasil
Authors: Hoefel João Luiz de Moraes , Machado Micheli Kowalczuk , Hamasuna Marcio Hiro , Vernalha Estevão Brasil Ruas
Published: November 2023

Aims: This paper presents and analyses actions related to Sustainability and Sustainable Development Goals (SDGs), present in Business Area Courses, taken by UNIFAAT – University Centre, located in Atibaia, São Paulo, Brazil. This work also addresses the view of students on sustainability and their interest and involvement with these actions.

Study Design:  Sustainability topics were gradually incorporated in different disciplines, themes of Completion of Course Works, Scientific Research, in a Research Centre in Sustainability and Culture, and in sustainable policies, implemented in the campus such as waste and water resources management and energy consumption and they are analysed in this paper.

Place and Duration of Study: The study was realized at UNIFAAT – University Center between June 2021 to July 2023.

Methodology: The methodology adopted for the development of this work is characterized as quali and quantitative and involves bibliographical and documentary research, an analysis of actions implemented by UNIFAAT in the area of sustainability, and a survey through a self-administered questionnaire used as a technique for collecting information on sustainable strategies knowledge from UNIFAAT business courses students. A total of 426 questionnaires were applied.

Results: From the data, projects, and actions analysed, it was possible to observe an expansion in the sustainable approach in business area courses.

Conclusion: The results are related to the efforts of higher education institutions to make it possible to achieve the SDGs, in a perspective that goes beyond governance at the internal level, collaborating as an important source of knowledge and to sustainable strategies in an inclusive way and beyond the campus.
Knowledge and Practice of Basic Life Support among Health Workers in the Upper Denkyira East Municipality of Ghana
Authors: Gyaase Philip , Acheampong Emmanuel Boateng , Adu-Gyamfi Isaiah , Armah Bridget , Amewolah Gifty Delali , Adueming Emmanuel Osei-Wusu
Published: November 2023

Background: The medical procedure known as cardiopulmonary resuscitation (CPR) can save a person's life after a heart attack. Additionally, it is done to manually preserve full brain function while additional measures are taken to recover spontaneous breathing and normal unprompted blood circulation in cardiac arrest.

Methods: The study's goal was to assess the knowledge and practice of basic life support among health workers in the Upper Denkyira East Municipality, Central Region of Ghana. The study used cross-sectional design. The study respondents were chosen using a simple random sampling method which included 322 nurses, doctors, physician assistants and midwives working in the Municipality. Data were collected using a standardized questionnaire. Data were analysed with SPSS version 25 and summarized using frequencies and percentages. Pearson's chi-square test and multivariate logistic regression were used to examine associations at a 5% significance level. Results: The study found that while all health care workers had heard about BLS, they only had an average of 68.9 percent understanding of basic life support and just 16.5 percent had practiced CPR before. Also, there was significant association between sociodemographic characteristics (sex, grade, educational level, department and work experience) of the health workers and the practice of basic life support (p-value=<0.001).

Conclusion: The study concludes that if health workers are given more training and support, the knowledge and practice of basic life support would be increased in the Upper Denkyira East Municipality.
Nurses’ Experience of Self-Management Support for Hospitalised Cardiac Patients: A Descriptive Qualitative Study
Authors: Alsolamy Salwa
Published: November 2023

Aim: This study explores nurses' experiences supporting hospitalized cardiac patients' self-management practices and associated factors that enhance the implemention of these practices.
Background: There has been less effort given toward activating the role of self-management in the early stages of hospitalized patients’ post-cardiac events. Knowing that nurses’ experience of supporting self-management practice and the factors that empower the application of self-management practice in hospitalized patients’ post-cardiac events are not well defined, exploring nurses’ experiences in the application of a self-management approach for cardiac patients and the relevant factors will identify areas for potential improvement in supporting self-management practice as part of nursing care.
Methods: A qualitative research design was adopted using in-depth interviews with eight registered nurses in the eastern region of Saudi Arabia who worked with hospitalized post-cardiac events were conducted. Registered nurses’ participation in this study was voluntary and approached through obtaining their contact information from the nursing offices in the selected hospitals.
Results: The defined themes in this study were directed by the concepts of Orem’s Theory, and four major sub-themes emerged from this study: initiation of self-management practices, self-management system, components of self-management for cardiac patients, and nursing practice issues.
Conclusion: Initiating self-management practices at early stages for hospitalized cardiac patients’ post-cardiac events ensured achieving better control and sustained practice.  Before establishing any plan, certain factors need to be considered, including patient-related factors, healthcare system, and nursing-related factors. Self-management practice for cardiac patients requires the support of multi-disciplinary teams and a well-integrated system. Nursing roles need to be defined and empowered in the healthcare system to be able to support self-management practices for hospitalized cardiac patients.
Antimalarial Effects of Ethanolic Leaf Extracts of Azadirachta indica and Ocimum gratissimum, and Their Histologic Effects on Some Organs (Liver, Kidney and Heart) of Plasmodium berghei Infected Albino Mice
Authors: C. C. Anyasodor, , A. E. Onyido, , E. O. Ogbuefi, , A. E. Anyasodor,
Published: November 2023

Azadirachta indica (Neem) and Ociumum gratissimum (clove Basil) have long been employed locally for the management of malaria. The present study compared antimalaria activities of the ethanolic leaf extracts of the individual plants, and assessed their combined effects on some organs of malaria-infected mice, at the Parasitology and Histopathology units, Federal Medical Centre (FMC), Owerri, from January to March, 2021. The leaves of the different plants were extracted with absolute ethanol (BDL 95%) for the test. Clean albino mice were experimentally infected intraperitoneally with chloroquine-sensitive Plasmodium berghei NK65 strain. Parasitaemia level was determined before parasite inoculation and at 24 hours post treatment period. Histopathological study on the liver, kidney, and heart was carried out using the Paraffin Setions method. Extracts of the leaves were administered orally, while chloroquine administration was intramuscular. The efficacy of the leaf extracts was tested on the P. berghei infected albino mice using the 4-day  curative test. The lethal median dose (LD50) recorded for neem and clove basil leaf extracts were 31.62 and 1246.9 mg/kg body weight, respectively. Significant activity against the parasite was produced by infected mice treated with extracts of A. indica and O. gratissimum, and their combinations throughout the treatment period (P<.05). Highest reduction of parasitaemia was observed on day 4. Maximum parasitaemia reduction (78.65%) was attained with 30mg/kg of the combined extracts on the 7th day. Mild pathological lesions were observed in mice treated with A. indica leaf extract. These observations indicate better anti-malaria activity of the combination therapy as compared with the individual extracts of A. indica and O. grassimum, and indicate good antimalarial and protective roles of the plant extracts on the parasitized mice at large, as it slows down development of resistance.
Patient Usage of Apps to Access Online Medical Records
Authors: Barker Wesley , Richwine Chelsea
Published: November 2023

This cross-sectional study analyzes the use of patient portal apps and third-party apps for managing multiple patient portals between 2019 and 2022.