Advancements in Urethral Reconstruction Using Biodegradable Tissue: A Comprehensive Review
Authors:   Hospital del Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado Zacatecas. Zacatecas, Zacatecas, Mexico., Mancillas Mario Hernandez , Pérez Héctor Cisneros ,   Hospital del Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado Zacatecas. Zacatecas, Zacatecas, Mexico., Sanchez Luis Jorge Caldera ,   Hospital del Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado Zacatecas. Zacatecas, Zacatecas, Mexico., Valerio Víctor Mario Ortega ,   Hospital del Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado Zacatecas. Zacatecas, Zacatecas, Mexico., Madrid Tania Celina Rodríguez ,   Hospital del Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado Ciudad Juarez Chihuahua. Chihuahua, Mexico., Mendoza Javier Villalobos ,   Hospital de especialidades, Centro Médico Nacional de Occidente. Guadalajara, jalisco, Mexico.
Published: November 2024

Urethral reconstruction, a pivotal domain within the realm of urology, has undergone a transformative evolution with the advent of innovative strategies utilizing biodegradable tissue. This article presents a comprehensive exploration of the burgeoning field of Urethral Reconstruction with Biodegradable Tissue (URBT), shedding light on its intricate nuances and clinical implications.

The utilization of biodegradable materials in urethral reconstruction represents a paradigm shift aimed at circumventing the limitations inherent in traditional non-biodegradable approaches. The inherent ability of these materials to provide temporary structural support during the critical phases of tissue healing, coupled with subsequent degradation, obviates the need for secondary interventions for material removal, thus mitigating the risk of complications associated with prolonged foreign body presence.

This review scrutinizes the biomechanical properties of various biodegradable scaffolds, examining their capacity to withstand physiological stresses while fostering optimal tissue regeneration. Immunological responses to these materials are also elucidated, providing insights into the biocompatibility and host reactions critical for long-term success. Furthermore, the nuanced kinetics of biodegradation are explored, emphasizing their impact on the temporal dynamics of tissue healing and functional restoration.

Delineating the clinical applicability of diverse biodegradable constructs, ranging from synthetic polymers to naturally-derived matrices, constitutes a focal point of this analysis. The article critically evaluates the outcomes and complications associated with URBT, providing a comprehensive understanding of the efficacy and challenges inherent in this emerging field.

As the landscape of urological surgery continues to evolve, this article serves as a beacon for clinicians, researchers, and medical practitioners navigating the complexities of urethral reconstruction. By delving into the molecular intricacies and clinical implications of URBT, it aims to contribute substantively to the ongoing discourse that shapes the future trajectory of urological surgery, offering a roadmap towards optimized patient outcomes and improved quality of life.