bluuebunny/crossref_metadata_2025 huggingface dataset:
Quando o exame neurológico não tranquiliza: um caso de doença de Creutzfeldt-Jakob
Authors:   USF Nova Via, Santos Gisela Marcelino , Ferreira Maria ,   USF Nova Via, Pinheiro Marta ,   USF Nova Via, Maganete Ângela ,   USF Nova Via
Published: September 2022

Introdução: A doença de Creutzfeldt-Jakob (DCJ) é a mais comum das doenças priónicas humanas. A maioria dos casos é esporádica e apresenta-se como demência rapidamente progressiva. Este caso pretende alertar para a importância da suspeição inicial de uma DCJ, apesar da sua raridade, de modo a reconhecer os primeiros sinais e sintomas, muitas vezes inespecíficos, e realizar uma referenciação célere aos cuidados de saúde secundários para diagnóstico e seguimento precoces. Descrição do caso: Mulher de 53 anos, sem antecedentes de relevo, que recorreu a consulta aberta da sua Unidade de Saúde Familiar por tonturas, desequilíbrio e humor distímico. Dias mais tarde apresentou-se com nistagmo horizontal, ataxia da marcha e dismetria dos membros superiores, pelo que foi orientada para observação por neurologia. O quadro clínico evoluiu em poucas semanas, com dificuldade em executar atividades da vida diária, apatia, discurso pobre, dificuldades na memória e apraxia para vestir. O exame neurológico revelou hiperreflexia esquerda, reflexo cutâneo-plantar esquerdo em extensão, postura distónica de ambos os membros superiores e mioclonias espontâneas de novo, com startle marcado com estímulo sonoro. A ressonância magnética (RM) mostrou sinais sugestivos de DCJ. A eletroencefalografia (EEG) e a proteína 14-3-3 positiva suportaram o diagnóstico. O estado neurológico deteriorou-se rapidamente, com evolução para mutismo acinético, tetraparésia espástica e morte. Comentário: A DCJ deve ser considerada perante a combinação de demência rapidamente progressiva e mioclonias estimulossensitivas. Manifestações cerebelosas constituem sintomas de apresentação em 20% a 40% dos casos. A RM, a proteína 14-3-3 e o EEG são úteis para o diagnóstico. O diagnóstico definitivo requer a combinação com os achados neuropatológicos. O tratamento é apenas de suporte e o desfecho fatal, sendo fulcral mostrar disponibilidade e apoio nas questões médicas, psicológicas e sociofamiliares.
Sistemas de nebulização em idade pediátrica: uso domiciliário em São Miguel
Authors:   Médico de Família, Arruda Augusta , Fechado Joana ,   Médico de Família, Caldeira Francisco Nunes ,   Médico de Família, Machado Ana Isabel ,   Médico de Família, Eloi Carolina ,   Médico de Família, Resendes Carolina ,   Médico de Família, Amaral Beatriz ,   Médico de Família, Ventura Ana ,   Médico de Família
Published: September 2022

Introdução: As doenças respiratórias são uma causa major de morbilidade em idade pediátrica. Os sistemas de nebulização, durante anos os dispositivos mais indicados para administração de aerossolterapia em crianças, foram suplantados pelos dispositivos simples de inalação. As linhas de orientação clínica atuais restringem a prescrição e utilização de nebulizadores. O objetivo do estudo é investigar a utilização domiciliária de sistemas de nebulização em idade pediátrica na Unidade de Saúde da Ilha de São Miguel. Método: Estudo observacional, transversal e analítico. Inclusão de crianças dos zero aos sete anos e 365 dias de idade, inscritos na Unidade de Saúde da Ilha de São Miguel. Aplicação de inquérito sob a forma de questionário aos acompanhantes da população-alvo para avaliação do contexto de aquisição, utilização e manutenção dos sistemas de nebulização. Calculada uma amostra significativa de 380 utentes (intervalo de confiança de 95%). Resultados: Participação de 387 utentes. Média de idades de 2,5 anos. 45,7% dos inquiridos afirmou possuir um nebulizador, enquanto 18,9% referiu possuir um dispositivo de inalação simples. A taxa de aquisição e utilização dos sistemas de nebulização sem prescrição médica foi de 67,8% e 79,7%, respetivamente. O custo da aquisição do sistema de nebulização foi entre 80 e 150 euros em 38,4%. A maioria da utilização não supervisionada ocorreu com soro fisiológico e no contexto de obstrução nasal (41,1%) e tosse (24,9%). Conclusão: O presente estudo evidencia a aquisição e utilização excessiva, não supervisionada e inapropriada dos sistemas de nebulização. A presente investigação deverá motivar a promoção da utilização dos dispositivos simples através da educação dos utentes, cuidadores e profissionais de saúde, visando melhorar a prática de saúde local.
Quando eu for grande, quero ser...
Authors:   Faculdade de Medicina da Universidade de Coimbra, Caniço Hernani
Published: September 2022

Quando eu for grande, quero ser médica de família. A Sofia tem 7 anos, os seus pais não são médicos e tem a liberdade criativa que a sua idade e as suas características lhe permitem fruir.
Mental Health in Uganda and Canada: A Descriptive Case Study of the Issue and Recommendations for Improved Mental Health
Authors: Mackie Cayley Lynn , Bradford Lori , Enanga Eric
Published: September 2022

Mental health is a crucial part of overall wellbeing. Canada’s mental health system has progressed over the last decade but still has room for improvement. In comparison, developing countries, such as Uganda, have not shown the same progression with their mental health systems. The embedded experience, together with expert consultations in the field, was conducted over several months at a human immunodeficiency virus (HIV) specialized hospital, the Joint Clinical Research Center (JCRC) in Kampala, Uganda on the topic of mental health systems. The observations and consultations were thematically analyzed into four main themes: cultural attitudes towards mental illness, the interconnectedness of childhood HIV and mental health, a gap in education for mental health professionals to become certified, and barriers to addressment of mental health issues at the JCRC. The main barriers for Ugandans seeking professional treatment were also identified, which included the accessibility and availability of professional treatment. Local solutions are outlined, as well as recommendations for improvements and future research.
What Do Christina Rossetti and Emily Ratajkowski Have in Common?: Gendered Power Dynamics in the Relationship Between the Female Model and the Male Artist
Authors: Funk Nakita
Published: September 2022

In her work, the Victorian poet Christina Rossetti explored women’s issues such as the objectification of women and the unequal standards that women were held to. One such issue, demonstrated in “In an Artist’s Studio,” was the controlling and manipulative relationship between the male artist and the voiceless women they immortalize in poetry and visual art. In the twenty-first century, the relationship between female muse and male artist remains complicated and often victimizing, as outlined by Emily Ratajkowski’s essay on her experiences as a supermodel. Common themes between Rossetti’s poetry and Ratajkowski’s essay demonstrate that male artists historically and currently require female models to conform to standards that are male-defined and unattainable, forcing the model to disassociate her body from her identity to perform her job. However, female artists and models redefining beauty standards and reuniting their identities with their bodies suggest that the future of modelling will give the model control over her own image.
Analisis Pembiayaan Murabahah dan Solusi Permasalahannya pada BMT Rizky Barokah Cabang Talun Magelang
Authors: Yulita Siska , Panggiarti Endang Kartini
Published: September 2022

The murabahah finance is sell and buy transaction which is seller acknowledge selling price and buyer pay to the seller as much as the price plus margin that being approved. Sometimes on going murabahah finance promise found obstacles and resistance being faced bank or debtor party. There for, we want to study more deep about murabahah finance in BMT RIzky Barokah as a research object. The research aims to analysis of the operation of murabahah finance, analysis of murabahah operation in KSPPS BMT Rizky Barokah with Fatwa Dewan Syariah Nasional (DSN MUI), and analysis of member perception of KSPPS BMT Rizky Barokah about murabahah finance. This type of research is qualitative research with data analysis techniques, namely data reduction, data display, and conclusion drawing and verification. The result is found conclusion that is process of operationalization of murabahah finance in KSPPS BMT Rizky Barokah different based on object of goods in the murabahah promise. There is a goods that have facilitated by BMT is motor-bicycle but there is have another goods that proxies by another party for the procuration. The execution of murabahah finance promise in Rizky Barokah has appropriate to the commandment and requirement of murabahah and appropriate with fatwa provisions DSN-MUI No. 04/DSN-MUI/IV/2000 about murabahah finance.
Comparison of alkali concentration for obtaining fine Musa Sapientum (banana) fibers to enhance potential applications
Authors: ŞENAY Rabia İzel , ÖZDEMİR Havva Nur , SEKİ Yasemin , KESKİN Özgür Yasin , DALMIŞ Ramazan , KÖKTAŞ Serhan , ERDOĞAN Ümit Halis
Published: September 2022

The objective of the present research was to investigate the efficiency of alkali treatment on obtaining fine banana fibers. The fibers were exposed to alkali aqueous solutions at different concentrations changing from 5 to 20 wt%. The acting mechanism of the alkali treatment is removing of non-cellulosic constituents and separating the fiber bundle into smaller elementary single fibers. The efficiency of the alkali treatments was analyzed with the help of optical observations, fiber diameter measurement, single fiber tensile test and determination of pectin component. Chemical, crystalline, thermal and morphological properties of the fibers were examined by FTIR, XRD, TGA and SEM, respectively. FTIR analyses proved the removal of non-cellulosic components such as hemicellulose and lignin after alkali treatment. Fiber diameter decreased with increasing concentration of alkali treatment. Tensile properties and crystallinity index are correlated with alkali concentration. However, cellulose structure of the banana fiber was altered at mild alkali treatments. Microscopic observations revealed the appearance of single elementary fibers from the fiber bundle of the banana. These experimental findings suggested that alkali treatment can play promising role to prepare lignocellulosic fibers for textile applications.
Relación de las alteraciones del sueño con el desarrollo de diabetes mellitus gestacional
Authors: Valencia-Ortega Jorge , Acosta-Bustos Jocelyn , Guzmán-Medina Diana Ghislaine , Saucedo-García Renata Patricia
Published: September 2022

Dormir es una actividad fundamental para la salud, por lo que cuando ocurren alteraciones del sueño aumenta el riesgo de trastornos metabólicos, cardiovasculares, endocrinos y neurológicos. Los cambios anatómicos y la fisiología respiratoria del embarazo afectan el curso normal del sueño, impactando en la salud de la mujer embarazada a tal grado que las alteraciones del sueño durante la gestación se asocian con un mayor riesgo de complicaciones obstétricas como la diabetes mellitus gestacional (DMG). La DMG afecta del 4 al 30% de los embarazos en México y se asocia con complicaciones a corto y largo plazo tanto en la madre como en el neonato. Una serie de estudios recientes proporcionan evidencia de una relación entre la alteración del sueño con el desarrollo de DMG y proponen al estrés oxidativo, la inflamación, la activación del sistema nervioso simpático y la desregulación hormonal como mecanismos subyacentes de dicha relación. Esto pone de relieve la importancia de la alteración del sueño como un factor modificable dirigido a una disminución de la frecuencia de DMG. El objetivo de este trabajo es realizar una revisión descriptiva de los diferentes estudios publicados desde el año 2013 al 2022, que han abordado la relación entre la alteración del sueño con el desarrollo de DMG con énfasis en los mecanismos propuestos. Las bases de datos utilizadas fueron PubMed Central y Scielo, utilizando las palabras clave: trastornos del sueño y diabetes gestacional.
PERCEIVED VALUE AND TRUST TOWARDS PATIENT LOYALTY: A LITERATURE REVIEW
Authors: Az Zahra Salsabila , Naili Farida  , Septo Pawelas Arso
Published: September 2022

Increasing patient loyalty through patient-provider relationships becomes the key factor in medical providers’ successes. Perceived value is the long-term value that customers provide to hospitals. The creation of added value for customers, and increasing the level of satisfaction will make a major contribution to the possibility of customers staying, and customers are increasingly valuable to service providers. This study explored the mediated relationship between patients’ perceived value, trust, and patient loyalty. This study aims to examine the perceived value and trust in patient loyalty both in hospitals and medical centers. This literature review study was searched from 3 databases, namely PubMed, Scopus, and Google Scholar published between January 1, 2018-May 31, 2022. Inclusion criteria were research on medical care loyalty, experience in the patient's perceived value of hospital services, and patient’s trust in the hospital. A total of 11 from 86 articles found were selected for review. Based on 11 articles that have been reviewed discussing customer value and trust in patient loyalty. Hospital and Medical Center as health provider has a relationship between patients’ perceived value of medical services, commitment to the patient-provider relationship, and patient loyalty. Furthermore, when the patient demonstrated higher levels of trust in a healthcare provider, the relationship of perceived value, commitment, and patient loyalty was also enhanced.
Proyecto de creación de la agencia de viajes WinterSun
Authors: Alonso Remedios Frandiel , Márquez Hernández Inara Esther , Sánchez Borges Yennifer , Velastegui López Luis Efraín
Published: September 2022

En el contexto de crisis impuesta por la COVID-19, se han generado profundos cambios en las dinámicas del sector turístico, siendo imprescindible el restablecimiento de la demanda de los principales mercados emisores de turistas. En el caso de Cuba, pese a la pandemia, se había manifestado un fuerte crecimiento de visitantes rusos al destino, hecho que condujo    a que se colocasen en él altas expectativas que se desdibujaron a raíz del conflicto bélico Rusia-Ucrania, pero que, dado los ritmos de crecimiento sostenidos del mercado ruso en Cuba durante los últimos años, se evidencia la necesidad de incentivar las estrategias de captación de este mercado y lograr una mayor especialización en su comercialización ante su salida del conflicto bélico. En base a ello, se plantea como objetivo de la investigación: Elaborar el proyecto de creación de una agencia de viajes física especializada en el mercado ruso en el destino turístico Varadero. Para ello se utilizó un procedimiento de elaboración propia a partir de diferentes metodologías consultadas sobre el tema y una serie de métodos teóricos y empíricos que permitieron la realización de un análisis integral de las variables más importantes en la que incurre la constitución de la agencia. Como principales resultados de la investigación destaca el diseño preliminar de la oferta, conformada por excursiones, circuitos y rutas como productos principales; el análisis de la competencia, la identificación de los recursos y trámites necesarios para la apertura, y la definición de la misión, visión, propuesta de valor y perspectivas y temas estratégicos.
Three consecutive recurrent ectopic pregnancy-A Case Report
Authors: Akhter Shirin , Yasmeen BH Nazma , Bakth Choudhury Chishti Tanhar
Published: September 2022

Ectopic pregnancy (EP) is a potentially life-threatening condition, leads to increased maternal mortality and morbidity till date. About 2% of all pregnancies are Ectopic one and recurrence rate is as high as 1 in every 10 pregnancies. Here we present a case who had a history of 2 Ectopic pregnancies – 1st one treated surgically and 2nd one by medical method. Unfortunately, 3rd pregnancy was also an Ectopic one and needed surgical management. Thus, her natural reproductive ability went down and had to go for In vitro fertilization (IVF) pregnancy and successfully got twin baby (Girl, on March,2020).
Northern International Medical College Journal Vol. 12 No.1 July 2020, Page 511-514
THE TRANSFORMATION OF DESPAIR TO HOPE AS ASSERTED ON RYUNOSUKE AKUTAGAWA’S SHIRO
Authors: Pasopati Rommel Utungga , Listyaningsih Listyaningsih , Wulandari Siti
Published: September 2022

Psychology in literature is how characters move through relation of body and mind. Shiro is Ryunosuke Akutagawa’s short story about white dog who ignores his friend, Kuro, that being caught. That ignorant deed haunts and makes him try to kill himself but actually he helps many people. One night, he speaks to the moon how he apologizes for everything. Then, how is transformation from despair to hope be asserted on Ryunosuke Akutagawa’s Shiro? Through qualitative method, this writing underlines changing condition of Shiro from having despair to being hopeful. Supported by theory of Randolph M. Nesse, the transformation is reflected when Shiro sees others beside himself. He leaves his loneliness and joins others for happiness. He has paid his debt by supporting others’ lives. In conclusion, Shiro’s denial for not helping Kuro changes when experiencing hope from otherness rather than selfness.
UNSUR RETORIKA DALAM SURAT ZAINAB KEPADA HAMID DALAM NOVEL DI BAWAH LINDUNGAN KA’BAH KARYA BUYA HAMKA
Authors: Supriyadi Miftah Wangsadanureja
Published: September 2022

Pada dasarnya retorika adalah bagaimana kemahiran atau gaya bicara seseorang dalam berbicara dihadapan umum, seperti berpidato atau berkhutbah. Namun, retorika juga bisa terdapat pada sebuah tulisan, yaitu bagaimana si penulis sastra menggunakan bahasa dan makna untuk mengungkapkan ide atau gagasan pengarang sehingga gagasan tersebut disampaikan secara jelas dan efektif tanpa mengurangi nilai estetika tulisan tersebut. Artinya retorika dalam tulisan adalah bagaimana si penulis mengungkapkan sebuah gagasan melalui tulisan yang memiliki nilai estetika. Dalam penelitian kecil ini penulis akan menkaji unsur-unsur retorika yang terdapat  pada surat Zainab kepada Hamid yang tersimpan dengan baik dalam novel “Di bawah Lindungan Ka’bah” karya Buya Hamka. Metode penelitian yang digunakan untuk menganalisis data adalah metode kualitatif deskriftif naratif. Hasil penelitian menunjukan bahwa surat Zainab terhadap Hamid terdapat beberapa unsur retorika, diantaranya adalah; 4 majas, 4 penyesiatan Struktur, dan 1 pencitraan yang terdiri dari pencitraan gerakan, penglihatan dan penciuman.
Pengaruh Independensi Auditor, Skeptisisme Profesional, dan Objektivitas Auditor terhadap Kualitas Audit
Authors: Panggabean Keiko Alina , Pangaribuan Hisar
Published: September 2022

Quality audits that have high quality and can be trusted are very important, in practice, the auditor must have a responsibility to build trust in the quality of the audits published. This study aims to analyze the effect of Auditor Independence, Professional Skepticism, and Auditor Objectivity on Audit Quality. The population in this study is the collection of data in this study is a Public Accounting Firm (KAP) located in Jakarta and its surroundings and a survey approach was carried out by distributing questionnaires to 112 respondents using quantitative descriptive methods. The data analysis tool used in this study uses SPSS (Statistical Product Software Solution). The analytical method used is Multiple Regression Analysis. Data analysis was performed by descriptive statistical test, reliability test, normality test, multicollinearity test, heteroscedasticity test, T-test, and F test. The results of this study indicate that partially auditor independence, professional skepticism, and auditor objectivity have a significant effect on audit quality. Auditor Independence and Professional Skepticism have a positive and significant effect on Audit Quality. Meanwhile, Auditor Objectivity has a negative and insignificant effect on Audit Quality.

Keywords: auditor independence, professional skepticism, auditor objectivity, audit quality

 

Abstrak

Kualitas audit yang memiliki kualitas tinggi dan dapat dipercaya kebenarannya sangatlah penting. Dalam pelaksanaannya auditor harus memiliki tanggung jawab agar dapat membangun kepercayaan atas kualitas audit yang diterbitkan. Penelitian ini bertujuan untuk menganalisis pengaruh Independensi Auditor, Skeptisisme Profesional dan Objektivitas Auditor terhadap Kualitas Audit. Populasi dalam penelitian ini adalah Kantor Akuntan Publik (KAP) yang terletak di Jakarta dan sekitarnya dan penelitian dilakukan dengan pendekatan survey melalui penyebaran kuesioner kepada 112 responden dengan menggunakan metode deskriptif kuantitatif. Alat analisis data yang digunakan pada penelitian ini menggunakan SPSS (Statistical Product Sofware Solution).  Metode analisis yang digunakan adalah Analisis Regresi Berganda. Analisis data dilakukan dengan uji statistik deskriptif, uji reabilitas, uji normalitas, uji multikolinearitas, uji heterokedastisitas, Uji T dan Uji F. Hasil penelitian ini menunjukkkan bahwa secara parsial Independensi Auditor, Skeptisisme Profesional dan Objektivitas Auditor berpengaruh signifikan terhadap Kualitas Audit. Independensi Auditor dan Skeptisisme Profesional berpengaruh positif dan signifikan terhadap Kualitas Audit. Sedangkan Objektivitas Auditor berpengaruh negatif dan tidak signifikan terhadap Kualitas Audit.

Kata kunci: independensi auditor, skeptisisme profesional, objektivitas auditor, kualitas audit
Pengaruh Health Concsiousness, Perceived Risk Of Covid-19 dan E-Wom terhadap Intensi Membeli Suplemen Vitamin C
Authors: Finley Michael , Keni Keni
Published: September 2022

Since March 2020, Indonesia has been disrupted by the Covid-19 pandemic that has impacted people's lives in every province, one of which is Jakarta, which has a large population and is the center of the economy and the capital city. This pandemic has forced people to live new and healthier habits, such as purchasing health products to start a healthy lifestyle to protect themselves from Covid-19. This study aims to empirically examine the effect of health consciousness, perceived risk of Covid-19, and e-WOM on the purchase intention of Vitamin C supplements. The research design used is descriptive and conclusive. The population in this study is consumers of vitamin C supplement products in Jakarta. This study used non-probability sampling by using convenience sampling. The number of samples obtained by using Google Form is 200 samples. The measurement of each indicator uses a 5-point-Likert-scale, and the collected data were analyzed using Partial Least Square-Structural Equation Modeling. This study concluded that health consciousness and e-WOM could predict consumers' intention to purchase Vitamin C supplements. Still, the perceived risk of Covid-19 cannot indicate the intent to acquire Vitamin C supplements consumers positively.

 

Keywords: Purchase intention, health consciousness, perceived risk of Covid-19, e-WOM

Abstrak

 

Sejak Maret 2020, masyarakat Indonesia telah dilanda oleh pandemi Covid-19 yang sangat berdampak pada kehidupan masyarakat di setiap provinsi, salah satunya di Jakarta, yang memiliki banyak penduduk, merupakan pusat perekonomian dan ibu kota. Pandemi telah memakasa masyarakat untuk memulai kebiasaan yang baru dan lebih sehat, seperti membeli produk kesehatan untuk memulai pola hidup yang sehat dalam rangka melindungi diri dari paparan Covid-19. Tujuan penelitian ini adalah untuk menguji secara empiris pengaruh health consciousness, perceived risk of Covid-19, dan e-WOM terhadap intensi membeli suplemen Vitamin C. Desain penelitian yang digunakan merupakan deskriptif konklusif. Populasi penelitian ini merupakan konsumen produk suplemen Vitamin C di Jakarta. Penelitian ini menggunakan non-probability sampling berupa convenience sampling. Jumlah sampel yang diperoleh dengan menggunakan Google Form sebanyak 200 sampel. Setiap indikator menggunakan skala likert 5 poin dan data yang diperoleh kemudian dianalisis dengan menggunakan metode Partial Least Square-Structural Equation Modeling. Penelitian ini menyimpulkan bahwa health consciousness dan e-WOM dapat memprediksi intensi membeli konsumen suplemen Vitamin C tetapi perceived risk of Covid-19 tidak dapat memprediksi intensi membeli konsumen suplemen Vitamin C secara positif.

 

Kata kunci: Intensi membeli, health consciousness, perceived risk of Covid-19, e-WOM
Faktor yang Memengaruhi Kejadian Low Back Pain pada Peternak Sapi Perah
Authors: Putri Ade Restina , Purwito Dedy
Published: September 2022

Nyeri punggung bawah (low back pain) merupakan masalah yang lazim terjadi pada pekerja termasuk pekerja di peternakan sapi. Gerakan yang berulang pada rentang waktu yang lama disertai posisi yang tidak ergonomis menjadi salah satu penyebab low back pain (LBP). Tujuan penelitian ini untuk mengetahui faktor yang memengaruhi kejadian LBP pada peternak sapi perah. Metode penelitian menggunakan metode deskriptif analitik dengan pendekatan cross-sectional. Sejumlah 45 pekerja berpartisipasi mengisi kuesioner start back screening toll sedangkan peneliti menggunakan Rapid Entire Body Assissment untuk mengukur posisi kerja. Hasil penelitian menunjukan 27 pekerja (60%) beresiko tinggi mengalami nyeri punggung bawah dan 18 pekerja (40%) beresiko sedang. Faktor usia (0,021), aktifitas fisik (0,0001), durasi kerja (0,0001) dan masa kerja (0,0001) mempunyai korelasi dengan kejadian LBP. Peregangan otot (streching), posisi kerja ergonomis, istirahat di sela aktifitas bisa mencegah atau mengurangi kesakitan LBP pada pekerja di peternakan sapi.
Tingkat Kecemasan Orang Tua tentang Pembelajaran Daring pada Anak Berkebutuhan Khusus di Masa Pandemi Covid-19
Authors: Hanggraeni Tiyas Budi , Anggraeni Atika Dhiah
Published: September 2022

Pandemi covid-19 di Indonesia berdampak pada berbagai bidang, terutama bidang pendidikan. Kementrian Pendidikan dan Kebudayaan mengambil kebijakan untuk pelaksanaan pembelajaran yang dilaksanakan dari rumah atau secara daring. Kondisi tersebut, menimbulkan perasaan cemas pada orang tua dengan anak yang berkebutuhan khusus. Penelitian ini bertujuan untuk mengetahui hubungan tingkat kecemasan orang tua tentang pembelajaran daring dengan pengetahuan anak berkebutuhan khusus pada masa pandemi covid-19. Penelitian ini merupakan penelitian kuantitatif dengan pendekatan cross-sectional. Sampel pada penelilitian ini adalah orang tua anak berkebutuhan khusus dengan jumlah 65 responden yang dipilih dengan teknik cluster random sampling. Hasil penelitian menunjukkan tingkat kecemasan orang tua dengan adanya pembelajaran daring sebagian besar dalam kategori ringan (50,8%). Pengetahuan anak berkebutuhan khusus pada saat pandemi covid-19 sebagian besar dalam kategori kurang (90,8%). Hasil analisis menunjukkan terdapat hubungan tingkat kecemasan orang tua dengan pengetahuan anak berkebutuhan khusus pada masa pandemi covid-19.
Teaching Civic Engagement Through Immersive Experience: Students’ Acquisition of Civic Knowledge, Skills, and Dispositions
Authors: Owen Diana , Irion-Groth Alissa
Published: September 2022

Civic knowledge, skills, and dispositions are necessary for responsible, productive, and engaged citizenship. Students from less privileged circumstances often attend poorly resourced schools and receive limited or substandard civics training that is especially devoid of attention to skills and dispositions. They also lack access to curricular interventions that take an active learning approach that is relevant to their needs and personal experience. We examine the effectiveness of two programs of the Center for Civic Education—the Congressional Academy for American History and Civics and Project Citizen. The programs take different approaches to active learning that facilitates students’ development of civic skills and dispositions. We find that both programs impart civic orientations to high-need students more effectively than traditional civics classes. Differences in civic learning based on SES, race, and gender were evident which points to the importance of designing civics curricula that meet the needs of diverse student populations.
CB1 Cannabinoid Receptor is a Target for Neuroprotection in Light Induced Retinal Degeneration
Authors: Soliño Manuel , Larrayoz Ignacio M. , López Ester María , Rey-Funes Manuel , Bareiro Mariana , Loidl Cesar Fabián , Girardi Elena , Caltana Laura , Brusco Alicia , Martínez Alfredo , López-Costa Juan José
Published: September 2022

In the last few years, an increasing interest in the neuroprotective effect of cannabinoids has taken place. The aim of the present work was to study the effects of modulating cannabinoid receptor 1 (CB1) in the context of light induced retinal degeneration (LIRD), using an animal model that resembles many characteristics of human age-related macular degeneration (AMD) and other degenerative diseases of the outer retina. Sprague Dawley rats (n = 28) were intravitreally injected in the right eye with either a CB1 agonist (ACEA), or an antagonist (AM251). Contralateral eyes were injected with respective vehicles as controls. Then, rats were subjected to continuous illumination (12,000 lux) for 24 h. Retinas from 28 animals were processed by GFAP-immunohistochemistry (IHC), TUNEL technique, Western blotting (WB), or qRT-PCR. ACEA-treated retinas showed a significantly lower number of apoptotic nuclei in the outer nuclear layer (ONL), lower levels of activated Caspase-3 by WB, and lower levels of glial reactivity by both GFAP-IHC and WB. qRT-PCR revealed that ACEA significantly decreased the expression of Bcl-2 and CYP1A1. Conversely, AM251-treated retinas showed a higher number of apoptotic nuclei in the ONL, higher levels of activated Caspase-3 by WB, and higher levels of glial reactivity as determined by GFAP-IHC and WB. AM251 increased the expression of Bcl-2, Bad, Bax, Aryl hydrocarbon Receptor (AhR), GFAP, and TNFα. In summary, the stimulation of the CB1 receptor, previous to the start of the pathogenic process, improved the survival of photoreceptors exposed to LIRD. The modulation of CB1 activity may be used as a neuroprotective strategy in retinal degeneration and deserves further studies.
Phosphate solubilization and plant growth promotion by two Pantoea strains isolated from the flowers of Hedychium coronarium L.
Authors: Prasad Priyanka , Kalam Sadaf , Sharma Naveen Kumar , Podile Appa Rao , Das Subha Narayan
Published: September 2022

Phosphorus (P) is an essential macronutrient for plants and is considered as one of the limiting nutrients to plants. The majority of P in the soil is found in the form of insoluble phosphate complexes, making the P unavailable for plants. In the present study, we report two highly efficient phosphate solubilizing bacteria isolated from the closed flower ofHedychium coronariumL., a medicinal plant commonly known as Gulbakawali. Based on morphological, biochemical, and molecular characterization, the two bacterial isolates were identified as genusPantoeaand designated as HCF6 and HCF9. Both these isolates efficiently solubilize tricalcium phosphate [Ca3(PO4)2] present in National Botanical Research Institute’s Phosphate (NBRIP) medium by releasing soluble phosphate up to 2000 μg ml-1and also partially solubilize aluminium phosphate (AlPO4). HCF6 and HCF9 possess several plant growth promoting traits and were evaluated for plant growth promotion ability using sand as a growth medium. Wheat plants treated with the bacterial isolates had increased root and shoot length and plant dry mass and accumulated higher inorganic phosphate in the plant tissue suggesting their role in mobilizing soluble P from insoluble P-complexes. Overall, our findings suggest that both thesePantoeaisolates (HCF6 and HCF9) represent promising candidates as bioinoculants.
Investigating the molecular mechanism of iguratimod act on SLE using network pharmacology and molecular docking analysis
Authors: Zeng Huiqiong , Chen Shuai , Lu Xiaoping , Yan Zhenbo
Published: September 2022

Objective: Iguratimod (IGU) is a novel small disease-modifying compound widely used in Asia for the treatment of rheumatic diseases. IGU is a methane sulfonanilide. We applied network pharmacology to investigate the pharmacological mechanisms of IGU act on SLE.

Methods: We used PharmMapper, UniProt, and OMIM databases to screen the potential targets of IGU, and the SLE-related disease targets were predicted. Hub target genes among the intersections of the potential targets (IGU) and related genes (SLE) were validated using the PPI network generated by the String database. GO and KEGG enrichment analyses were carried out using the David online platform. Finally, the molecular docking of hub targets and their corresponding compounds were completed through AutoDock Vina and PyMOL software for visualization.

Result: A total of 292 potential targets of IGU, 6501 related disease targets of SLE, and 114 cross targets were screened from the aforementioned database. Network topology analysis identified 10 hub targets, such as CASP3, AKT1, EGFR, MMP9, and IGF1. GO enrichment analysis mainly focuses on the negative regulation of the apoptotic process and signal transduction. KEGG enrichment analysis illustrated that the PI3K-AKT signaling pathway, MAPK signaling pathway, and FoxO signaling pathway might play a significant role in the pharmacological mechanisms of IGU act on SLE. Molecular docking confirmed that the IGU ligand had strong binding activity to the hub targets.

Conclusion: This study based on network pharmacology and molecular docking validation preliminarily revealed the protein targets affected by IGU acting on SLE through, and explored potential therapeutic mechanism role of IGU in SLE treatment by multi pathways.
PPy@Fe3O4 nanoparticles inhibit the proliferation and metastasis of CRC via suppressing the NF-κB signaling pathway and promoting ferroptosis
Authors: Yu Zhilong , Tong Shanshi , Wang Chenyi , Wu Zizhen , Ye Yingjiang , Wang Shan , Jiang Kewei
Published: September 2022

Colorectal cancer (CRC) is one of the most common cancers of the digestive tract, and patients with advanced-stage cancer have poor survival despite the use of multidrug conventional chemotherapy regimens. Intra-tumor heterogeneity of cancerous cells is the main obstacle in the way to effective cancer treatments. Therefore, we are looking for novel approaches to eliminate just cancer cells including nanoparticles (NPs). PPy@Fe3O4 NPs were successfully synthesized through a portable method. The characterization of transmission electron microscopy (TEM), Fourier-Transformed infrared spectrometer, and X-ray powder diffraction have further proved successful preparation of PPy@Fe3O4 NPs. NIR irradiation was used to test the photothermal properties of NPs and an infrared camera was used to record their temperature. The direct effects of PPy@Fe3O4 NPs on colorectal cancer cell DLD1 were assessed using CCK8, plate clone, transwell, flow cytometry, and western blotting in CRC cell. The effect of PPy@Fe3O4 NPs on neoplasm growth in nude mice was evaluated in vivo. This study demonstrated that PPy@ Fe3O4 NPs significantly inhibit the growth, migration, and invasion and promote ferroptosis to the untreated controls in colorectal cancer cells. Mechanical exploration revealed that PPy@Fe3O4 NPs inhibit the multiplication, migration, and invasion of CRC cells in vitro by modulating the NF-κB signaling pathway. Importantly, Ferroptosis inhibitors Fer-1 can reverse the changes in metastasis-associated proteins caused by NPs treatment. Collectively, our observations revealed that PPy@Fe3O4 NPs were blockers of tumor progression and metastasis in CRC. This study brought new insights into bioactive NPs, with application potential in curing CRC or other human disorders.
Design feature combinations effects of running shoe on plantar pressure during heel landing: A finite element analysis with Taguchi optimization approach
Authors: Yang Zihan , Cui Chuyi , Wan Xianglin , Zheng Zhiyi , Yan Songhua , Liu Hui , Qu Feng , Zhang Kuan
Published: September 2022

Large and repeated impacts on the heel during running are among the primary reasons behind runners’ injuries. Reducing plantar pressure can be conducive to reducing running injury and improving running performance and is primarily achieved by modifying the design parameters of running shoes. This study examines the effect of design parameters of running shoes (i.e., heel-cup, insole material, midsole material, and insole thickness) on landing peak plantar pressure and determines the combination of different parameters that optimize cushion effects by employing the Taguchi method. We developed the foot–shoe finite element (FE) model through reverse engineering. Model assembly with different design parameters was generated in accordance with the Taguchi method orthogonal table. The effectiveness of the model was verified using the static standing model in Ansys. The significance and contribution of different design parameters, and the optimal design to reduce plantar pressure during landing, were determined using the Taguchi method. In the descending order of percentage contribution was a conforming heel-cup (53.18%), insole material (25.89%), midsole material (7.81%), and insole thickness (2.69%). The more conforming heel-cup (p < 0.001) and softer insole (p = 0.001) reduced the heel pressure during landing impact. The optimal design of running shoe in this study was achieved with a latex insole, a 6 mm insole thickness, an Asker C-45 hardness midsole, and a 100% conforming heel-cup. The conforming heel-cup and the insole material significantly affected the peak plantar pressure during heel landing. The implementation of a custom conforming heel-cup is imperative for relieving high plantar pressure for long-distance heel-strike runners.
Pulsed electric field: A “green” extraction technology for biomolecular products from glycerol with fermentation of non-Saccharomyces yeasts
Authors: Tsapou Evangelia A. , Ntourtoglou George , Drosou Fotini , Tataridis Panagiotis , Lalas Stavros , Dourtoglou Vassilis
Published: September 2022

Glycerol is the main organic by-product of the biodiesel industry and it can be a source of carbon for fermentations or a substrate for biotransformations. This work investigates a process that uses pulsed electric field (PEF) to enhance polyol and propanediols extraction from a glycerol/glucose fermentation broth. Three different commercial, non-Saccharomyces strains, Torulaspora delbrueckii Prelude (Hansen), Torulaspora delbrueckii Biodiva 291 (Lallemand) and Metschnikowia pulcherrima (Lallemand) were studied. The results revealed that PEF had a positive impact on the extraction of polyols ranging from 12 to 191%, independently of fermentation conditions. Torulaspora delbrueckii Biodiva 291 (Lallemand) was found to be more efficient at pH 7.1. An optimized chromatography-based method for the qualitative and quantitative determination of the formed products evaluated. The experiments were carried out either in flasks or in a bioreactor.
HOX genes in stem cells: Maintaining cellular identity and regulation of differentiation
Authors: Steens Jennifer , Klein Diana
Published: September 2022

Stem cells display a unique cell type within the body that has the capacity to self-renew and differentiate into specialized cell types. Compared to pluripotent stem cells, adult stem cells (ASC) such as mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs) exhibit restricted differentiation capabilities that are limited to cell types typically found in the tissue of origin, which implicates that there must be a certain code or priming determined by the tissue of origin. HOX genes, a subset of homeobox genes encoding transcription factors that are generally repressed in undifferentiated pluripotent stem cells, emerged here as master regulators of cell identity and cell fate during embryogenesis, and in maintaining this positional identity throughout life as well as specifying various regional properties of respective tissues. Concurrently, intricate molecular circuits regulated by diverse stem cell-typical signaling pathways, balance stem cell maintenance, proliferation and differentiation. However, it still needs to be unraveled how stem cell-related signaling pathways establish and regulate ASC-specific HOX expression pattern with different temporal-spatial topography, known as the HOX code. This comprehensive review therefore summarizes the current knowledge of specific ASC-related HOX expression patterns and how these were integrated into stem cell-related signaling pathways. Understanding the mechanism of HOX gene regulation in stem cells may provide new ways to manipulate stem cell fate and function leading to improved and new approaches in the field of regenerative medicine.
A rapid, non-invasive method for fatigue detection based on voice information
Authors: Gao Xiujie , Ma Kefeng , Yang Honglian , Wang Kun , Fu Bo , Zhu Yingwen , She Xiaojun , Cui Bo
Published: September 2022

Fatigue results from a series of physiological and psychological changes due to continuous energy consumption. It can affect the physiological states of operators, thereby reducing their labor capacity. Fatigue can also reduce efficiency and, in serious cases, cause severe accidents. In addition, it can trigger pathological-related changes. By establishing appropriate methods to closely monitor the fatigue status of personnel and relieve the fatigue on time, operation-related injuries can be reduced. Existing fatigue detection methods mostly include subjective methods, such as fatigue scales, or those involving the use of professional instruments, which are more demanding for operators and cannot detect fatigue levels in real time. Speech contains information that can be used as acoustic biomarkers to monitor physiological and psychological statuses. In this study, we constructed a fatigue model based on the method of sleep deprivation by collecting various physiological indexes, such as P300 and glucocorticoid level in saliva, as well as fatigue questionnaires filled by 15 participants under different fatigue procedures and graded the fatigue levels accordingly. We then extracted the speech features at different instances and constructed a model to match the speech features and the degree of fatigue using a machine learning algorithm. Thus, we established a method to rapidly judge the degree of fatigue based on speech. The accuracy of the judgment based on unitary voice could reach 94%, whereas that based on long speech could reach 81%. Our fatigue detection method based on acoustic information can easily and rapidly determine the fatigue levels of the participants. This method can operate in real time and is non-invasive and efficient. Moreover, it can be combined with the advantages of information technology and big data to expand its applicability.
Brønsted acid catalyzed remote C6 functionalization of 2,3-disubstituted indoles with β,γ-unsaturated α-ketoester
Authors: Zhang You-Ya , Li Lin , Zhang Xiang-Zhi , Peng Jin-Bao
Published: September 2022

A metal-free catalytic approach for the remote C6-functionalization of 2,3-disubstituted indoles has been developed. In the presence of catalytic amounts of Brønsted acid, the β,γ-unsaturated α-ketoesters react with 2,3-disubstituted indoles at the C6 position selectively. Under mild reaction conditions, a range of C6-functionalized indoles were prepared with good yields and excellent regioselectivity. This methodology provides a concise and efficient route for the synthesis of C6-functionalized indole derivatives.
An outbreak of extensively drug-resistant and hypervirulent Klebsiella pneumoniae in an intensive care unit of a teaching hospital in Southwest China
Authors: Liu Siyi , Ding Yinhuan , Xu Yifei , Li Zhaoyinqian , Zeng Zhangrui , Liu Jinbo
Published: September 2022

Extensively drug-resistant and hypervirulent Klebsiella pneumoniae (XDR-hvKp) is a new problem for patients in Intensive Care Unit (ICU) and can become an even more severe threat if resistant to tigecycline, considered one of the ‘last lines of defense’ drugs. This study collected seven non-replicated tigecycline-resistant XDR-hvKp from seven patients and performed genome analysis and epidemiological investigation using whole genome equencing (WGS) and other methods. All strains in this study were identified as ST11-KL64 and showed high resistance to antibiotics such as β-lactams, aminoglycosides, quinolones, and tigecycline, and one strain was also resistant to colistin. All strains were determined to be hvKp by the results of serum resistance assay and Galleria mellonella infection models. All strains had resistance genes blaCTX-M-65,blaKPC-2,blaLAP-2,blaTEM-1B, rmtB, and qnrS1 and virulence factors such as rmpA, rmpA2, and aerobactin (iucABCD, iutA). The expression of the AcrAB-TolC efflux pump was upregulated in all strains, and the expression levels of the gene pmrK was significantly upregulated in colistin-resistant strain DP compared to colistin-sensitive strain WT in this study. In conclusion, we described an outbreak caused by tigecycline-resistant XDR-hvKp in the ICU of a teaching hospital in southwest China. The spread of these superbugs poses a great threat to patients and therefore requires us to closely monitor these XDR-hvKp and develop relevant strategies to combat them.
Increased atherosclerotic plaque in AOC3 knock-out in ApoE−/− mice and characterization of AOC3 in atherosclerotic human coronary arteries
Authors: Filip Anna , Taleb Soraya , Bascetin Rümeyza , Jahangiri Mohammad , Bardin Matthieu , Lerognon Cindy , Fève Bruno , Lacolley Patrick , Jalkanen Sirpa , Mercier Nathalie
Published: September 2022

Introduction

Amine oxidase copper containing 3 (AOC3) displays adhesion between leukocytes and endothelial cells and enzymatic functions. Given its controversial role in atherogenesis, we proposed to investigate the involvement of AOC3 in the formation of atherosclerotic plaques in ApoE−/−AOC3−/− mice and human coronary arteries.

Methods

Lesions, contractile markers, and AOC3 were studied in aortic tissues from 15- and 25-week-old mice and different stages of human coronary atherosclerotic arteries by immunohistochemistry (IHC) and/or western blot. Human VSMCs, treated or not with LJP1586, an AOC3 inhibitor, were used to measure differentiation markers by qPCR. AOC3 co-localization with specific cell markers was studied by using confocal microscopy in mice and human samples.

Results

At 15 weeks old, the absence of AOC3 was associated with increased lesion size, α-SMA, and CD3 staining in the plaque independently of a cholesterol modification. At 25 weeks old, advanced plaques were larger with equivalent staining for α-SMA while CD3 increased in the media from ApoE−/−AOC3−/− mice. At both ages, the macrophage content of the lesion was not modified. Contractile markers decreased whereas MCP-1 appeared augmented only in the 15-week-old ApoE−/−AOC3. AOC3 is mainly expressed by mice and human VSMC is slightly expressed by endothelium but not by macrophages.

Conclusion

AOC3 knock-out increased atherosclerotic plaques at an early stage related to a VSMC dedifferentiation associated with a higher T cells recruitment in plaques explained by the MCP-1 augmentation. This suggests that AOC3 may have an important role in atherosclerosis independent of its canonical inflammatory effect. The dual role of AOC3 impacts therapeutic strategies using pharmacological regulators of SSAO activity.