bluuebunny/crossref_metadata_2025 huggingface dataset:
What is dark matter? An attempt at a theological answer
Authors:   Kursk State University, Menshikov Vladimir M.
Published: January 2022

Based on the analysis of modern scientific data, the teachings of Russian religious thinkers about “Sophia” and S. L. Frank on reality, the biblical text concerning the creation of the world on the first day shows that dark matter is a special reality in the world. Modern science claims that there is a special “dark matter” in the world, which occupies up to ninety-five percent of the mass of all matter, but its properties are still unknown. Russian religious philosophers show that the creation of the world and matter by God was preceded by the birth of uncreated Sophia, the creation of created Sophia, or the “emanation” of “uncreated reality” and the creation of “created reality”. Based on the first words of the Bible, the assumption is made that the first verse “In the beginning God created the heavens and the earth” (Gen 1: 1) should be understood not as the creation of the real heaven and the real earth, which is stated in the Bible just below, but as a creation of the angelic world and some kind of special earth, which, apparently, actually is what today in science is referred to as dark matter. The article discusses its properties.
THE METHOD OF ITERATIVE SEARCH FOR THE OPTIMAL FIELD DEVELOPMENT OPTION
Authors: YUSHKOV Anton Yu. , Glumov Dmitry N. , Magizov Bulat R. , Shakhov Anton A.
Published: January 2022

3D hydrodynamic modeling is the standard tool for predicting the development of hydrocarbon (HC) fields. The relevance of the work is associated with the need to introduce fast and affordable optimization algorithms into engineering practice, which will reduce the cost of computer time to justify the best and most effective development solutions. The authors have proposed a new express method for finding the optimal option for the development of deposits. The method works with discrete sets of possible variations of the required development parameters (for example, the number of wells, the type of completion, the rate of hydrocarbon reserves withdrawal etc.) and minimizes the number of launches of the reservoir simulation simulator per forecast required for the feasibility of various combinations study of parameters and finding both local and global optimal combinations.
Compared with other methods, its advantage is simplicity and realizability in the “manual” mode with a small number of variable parameters, which can be useful for practical problems. The method uses the principle of iterations and is tested on several examples, including the results of hydrodynamic modeling, a comparison is made with known optimization algorithms — in some problems the method allows finding the optimum faster. For example, in the problem of finding the optimal location of horizontal wells, the iterative search turned out to be faster than the “swarm of particles” method. On the other hand, the method does not allow one to reliably determine the optima of complex objective functions that have several local optima. Testing was carried out on the Himmelblau and Rosenbrock functions: in the first case, all five local optima were found, in the second case, seven out of twelve.
STUDY OF SPATIAL HEAT TRANSFER IN A CORNER FRAGMENT OF AN EXTERNAL FENCE WITH CONNECTORS
Authors: IVANOVA Elena A. , Mescheulov Nikita V.
Published: January 2022

Increasing energy efficiency and reducing heat loss in buildings are the main challenges of the modern construction sector. For this reason, it is recommended to design buildings using modern energy-saving materials and technologies. When using multilayer walls in housing construction, the problem of thermal bridges arises. Therefore, you need to understand how the thermal behavior of the enclosing structure changes when thermal engineering inhomogeneities are included in it.
The aim of this work is to study the effect of heat-conducting inclusions located in external enclosing structures on the change in the values of temperature and heat flux density.
The paper considers the importance of increasing the energy efficiency of outdoor fences. A numerical study of the heat transfer process for corner fragments of enclosing structures used in housing construction using the VELOX technology has been carried out. The influence of the design features of the considered corner fragments on the characteristics of temperature fields is shown.
Mathematical modeling of spatial heat transfer in the corner fragment of the outer enclosure is carried out using a nonlinear system of differential equations of heat conduction with specified boundary conditions using the finite element method. The problem was solved using the ANSYS software package.
The influence of metal and fiberglass connectors on the change in the fields of temperature and heat flux density in the enclosing structure has been investigated. The change in the thermal state is considered both in the thickness of the outer wall and along the inner surface of the fence from the corner area and along the smooth surface of the wall. Analysis of the calculations showed that the maximum disturbance is introduced by the connector made of metal, and the minimum — from fiberglass. The presence of highly heat-conducting inclusions in the thickness of the structure leads to a distortion of the density field of the heat flux of the fence.
Aminoacyl-tRNA Synthetases, Indispensable Players in Lung Tumorigenesis
Authors: Banerjee Rajat , Bhowal Pratyasha , Karmakar Priyanka Biswas , Dey Debkanya , Manna Riya , Roy Debraj
Published: January 2022

Being an essential enzyme in protein synthesis, the aminoacyl-tRNA synthetases (aaRSs) have a conserved function throughout evolution. However, research has uncovered altered expressions as well as interactions of aaRSs, in league with aaRS-interacting multi-functional proteins (AIMPs), forming a multi-tRNA synthetase complex (MSC) and divulging into their roles outside the range of protein synthesis. In this review, we have directed our focus into the rudimentary structure of this compact association and also how these aaRSs and AIMPs are involved in the maintenance and progression of lung cancer, the principal cause of most cancer-related deaths. There is substantial validation that suggests the crucial role of these prime housekeeping proteins in lung cancer regulation. Here, we have addressed the biological role that the three AIMPs and the aaRSs play in tumorigenesis, along with an outline of the different molecular mechanisms involved in the same. In conclusion, we have introduced the potentiality of these components as possible therapeutics for the evolution of new-age treatments of lung tumorigenesis.
Correlation of Indeterminate Lesions of COVID-19 Pneumonia Detected
on Computed Tomography with RT-PCR Results
Authors: Aydin Nevin , Cihan Çağatay , Us Tercan , Öz Yasemin , Öztunalı Çiğdem , Yılmaz Şenay , Alataş Füsun , Erginel Sinan , Kurt Emel , Ak Güntülü , Yıldırım Hüseyin
Published: January 2022

Background:

The typical findings of COVID-19 pneumonia include multilobar groundglass
opacities and consolidation areas observed predominantly in the basal and peripheral parts of
both lungs in computed tomography.

Objective:

The current study aimed to correlate indeterminate lesions of COVID-19 pneumonia detected
on computed tomography with the results of the reverse transcription-polymerase chain reaction
(RT-PCR) test.

Methods:

Patients with high-resolution computed tomography images that were reported to contain
indeterminate lesions in terms of COVID-19 pneumonia were included retrospectively in the study.
The lesions were categorized and the patterns were classified. The RT-PCR-positive and the RTPCR-
negative patients were compared. P<0.05 was accepted as the statistical significance limit.

Results:

The RT-PCR-positive patients exhibited a higher rate of peripheral lesions. Limited consolidation
areas were not detected in the RT-PCR-positive patients. In the RT-PCR-negative patients,
the rates of acinar nodules and the tree-in-bud pattern were significantly higher. The RTPCR-
negative patients had higher nodular contour features and lesion coalescence. In the subgroup
consisting of lesions with ground-glass opacities and/or ground-glass opacity around the nodule,
the rate of nodular contour positivity was significantly higher in the RT-PCR- positive patients.

Conclusion:

COVID-19 pneumonia should be suspected when peripheral indeterminate lesions are
detected. When indeterminate lesions, such as tree-in-bud pattern, acinar nodules and limited consolidation
area are detected, alternative diagnoses should be considered first, even if there are
ground glass opacities accompanying these lesions.
Efficacy of VERIGENE® Blood Culture Assays in Accurately and Rapidly
Detecting Gram-Negative and Gram-Positive Pathogens
Authors: Guevara Roberto , Davis Monique G. , Davis Michelle A. , Ahmed Sara , Shah Sidra , Cuaron Karla , Antony Suresh J.
Published: January 2022

Background:

Rapid administration of appropriately indicated antibiotics is crucial in septic
patients. Sepsis data supports that there is a higher risk of mortality for each hour delay from triage to
antibiotic therapy, as well as for inappropriate antibiotic selection. There are a variety of rapid microbial
detection systems, such as VERIGENE®, used in acute care facilities to rapidly detect bacteremia
and identify resistance markers. Our study investigates the usefulness of VERIGENE® assays in accurately
detecting Gram-positive and Gram-negative pathogens when compared to traditional blood culture
analysis systems, such as VITEK®.

Methods:

819 Gram-positive and 373 Gram-negative blood samples were collected and tested using
both VERIGENE® and VITEK®. Statistical tests were two-tailed and observations were defined as
statistically significant if P ≤ 0.05.

Results:

VERIGENE® detected a pathogen in 816/819 (99.6%) samples of the Gram-positive blood
cultures and 367/373 (98.3%) samples of the Gram-negatives compared to 805/819 (98.3%) and
367/373 (98.4%), respectively, using VITEK®. Gram-positive cultures had a sensitivity of 99.5% and a
specificity of 27.3% (PPV 99.0%, NPV 42.9%, 98.7% accuracy) with VERIGENE analysis. Gramnegatives
had a sensitivity of 99.2% and a specificity of 20.0% (PPV 98.9%, NPV 25.0%, 98.4% accuracy).

Conclusions:

Although statistically insignificant (P = 0.25), VERIGENE® was 1.3% more likely to
identify Gram-positive bacteria when compared to conventional methods. Overall, we concluded that
VERIGENE® assays are valuable in their ability to rapidly detect microorganisms and resistance markers,
given their high sensitivities. This allows for select targeted therapy in patients with sepsis and can
ultimately reduce mortality rates.
effect of regulation, accountability systems, accounting principles, priority programs on performance accountability and performance reporting moderates of good financial governance of village
Authors: Wahyuandari Wenni , Ratnawati Tri , Riyadi Slamet
Published: January 2022

Research to prove, analyze and interpret the Effect of Regulation, Accountability System, Accounting Principles, Priority Programs on Performance Accountability, and Performance Reports in Village Fund Management with Moderate Variables Good Financial Governance (GFG) Village. This study uses a quantitative approach by collecting data through a survey of village heads who receive village funds. This study uses an explanatory approach by testing some hypotheses. The study population was in all villages receiving village funds in Tulungagung Regency in 2021. The number of samples was determined using the Slovin formula with a tolerance of 5% as many as 156 respondents. Sampling was done using Random Sampling, while the data analysis technique used Partial Least Square. Regulation, work accountability, accounting principles partially have a significant effect on performance Reports. Priority Programs have a significant effect on Performance AccountabilityandGFG can strengthen the relationship between the Village Fund Accounting Principles and the performance report.
KEANEKARAGAMAN JENIS SEMUT (HYMENOPTERA: FORMICIDAE) PADA EKOSISTEM TANAMAN TEBU PHT DAN KONVENSIONAL
Authors: Prayoga Nur Angga , Rahardjo Bambang Tri , Widjayanti Tita
Published: January 2022

Pada budidaya tanaman tebu (Saccharum officinarium L.) seringkali terjadi hambatan sehingga dapat menurunkan hasil produksi, salah satunya ialah serangan hama. Semut (Hymenoptera: Formicidae) merupakan serangga musuh alami yang berperan sebagai predator. Tujuan dari penelitian ini yaitu untuk mengetahui jenis – jenis semut, peran, dan pengaruh perbedaan yang terdapat di ekosistem tanaman tebu PHT dan konvensional. Kegiatan penelitian ini dilaksanakan pada bulan Agustus – Oktober 2020. Tempat kegiatan pelaksanaan penelitian yaitu di Balai Penelitian Tanaman Pemanis dan Serat, Karangploso, Malang. Penelitian ini bersifat deskriptif kuantitatif dengan menggunakan metode Pitfall trap dan umpan tuna. Berdasarkan hasil penelitian semut yang ditemukan pada lahan pengamatan terdiri dari 4 subfamili dan 9 genus semut. Jumlah keseluruhan genus semut yang di dapat pada lahan PHT yaitu 1506 individu dan pada lahan Konvensional 1240 individu. Keanekaragaman pada lahan pengamatan dalam keadaan yang stabil dengan keanekaragaman dalam kategori sedang. Tingkat penyebaran jenis hampir merata. Kekayaan spesies pada kedua lahan rendah serta tidak ada spesies yang mendominasi pada lahan PHT dan konvensional. Peran semut yang ditemukan pada lahan pengamatan yaitu sebagai predator dan sebagai pencari makan (foragers).
Economic Efficiency of the Main Oil Producing Countries in Upstream Sector in the Period 2010-2017
Authors: Navarro Chávez José César Lenin , Delfín Ortega Odette Virginia , Guardado Ibarra Enrique
Published: January 2022

This work aims to calculate the economic efficiency of the main upstream oil producing countries in 2010-2017, using the Data Envelopment Analysis (DEA) methodology. In the begining the technical efficiency is determined, next allocative efficiency is calculated to finally obtain the economic efficiency. The countries analyzed were: United States, Russia, Canada, China, United Arab Emirates, Kuwait, Brazil, Kazakhstan, Mexico, Angola, Venezuela, Algeria, United Kingdom, Holland, France and Spain. It can be seen from the results that no country was efficient in economic terms. However, Russia had the highest levels of economic efficiency, on the opposite side, France has the lowest values in this indicator. It is recommended to establish strategies in the sector to avoid economic vulnerability in some countries. The main limitation is the availability of the data. The originality of the research consists in obtaining economic efficiency in this industry, since there are no studies with these specific characteristics. It is concluded that in terms of economic efficiency, there was no adequate use of resources in the upstream oil industry.
Standardized Precipitation Index Comparison along the Limbe-Bamenda Axis of the Cameroon Gulf of Guinea
Authors:   Department of Geography and Planning, The University of Bamenda, Bamenda, Cameroon, Tume Suiven John Paul
Published: January 2022

Mean monthly rainfall decline with continentality is a commonplace phenomenon that has been used in this study to compare its trend in Bamenda in the Western Highlands and Limbe on the Atlantic lowland coast. This study attempts to bridge some of the methodological gaps in the previous studies on rainfall variability in Cameroon that had emphasized only the inter-annual variability and coefficient of variation without focusing on the specific indices and contrasts between different ecological zones. In this study, a comparative analysis has been done of the standardized precipitation index (SPI) for Bamenda and Limbe, using data from 1985–2015. The analysis involved the mean annual rainfall (176.88 mm and 419.9 mm), its standard deviation (SD) (22.98 and 102.42), and the coefficient of variation (CV) (12.99% and 24.41%) for Bamenda and Limbe, respectively. The results show that the mean annual rainfall for Bamenda is decreasing, whereas that of Limbe is increasing. The mean SPI is –0.01 (mild dryness) and 0.02 (mild wetness) for Bamenda and Limbe, respectively. These results have far-reaching implications for the development of agriculture, water resources management, and other man-environment interaction variants.
Experimental Investigation and Design Analysis of Hollow Glass Microsphere loaded PP/ABS Composites
Authors: Biswas Shreyas
Published: January 2022

Abstract: The objective of the present is to investigate hollow glass microspheres (HGMs) experimentally and carry out design analysis of hollow glass microsphere loaded PP/ABS composites. The tensile and notched Charpy impact test of HGM-filled acrylonitrile-butadiene-styrene copolymer (ABS) and Polypropylene (PP) composites will be studied with varying the concentrations of PP/ABS composite with HGM. Also further the design analysis will be studied by conducting the simulation under the same criteria and comparing the results at the end. This is done to introduce a light weight material without compromising specific strength of PP/ABS composite by adding HGM to the composite. Keywords: Hollow Glass Microsphere (HGM), ABS-Acrylonitrile butadiene styrene, PP- Polypropylene, Composites.
Ancients Ruins of Mahabharata Prominence Hastinapur Giving Vindication of Bioarchaeology
Authors: Bharati Priyank
Published: January 2022

Abstract: Hastinapur, capital of the Kuru Kingdom in the era of Mahabharata. Some ancient structures imply the name of Mahabharata personages such as Karna Ghat Mandir, Draupadi Ghat Mandir, Pandeshwar Mahadev Mandir, Pandv Tila, or Ulta Khera Mound, etc. In the year 1950-52 some portion of Ulta Khera and Mound of Raghunathji was excavated by B.B. Lal. He found 5 culture strata starting from Pre 1200 B.C. to the early 15th Century A.D and the first time he brings in limelight a new ceramic industry Painted Grey Ware. The recovery of somehow Kushan Period bones(?,for exact time period, the Archaeological Survey of India should remove all these evidences from the site and go through carbon dating.) from near site HST 2 connects this mound with Bio-archaeology. Keywords: Hastinapur, Ulta Khera Mound, Mahabharata, Bioarchaeology
Estudio comparativo de la composición florística, diversidad y productividad de vegas o mallines de Tierra del Fuego, Chile
Authors: Domínguez Erwin , Pérez Claudio
Published: January 2022

Desde un punto de vista funcional y productivo, las vegas o mallines, son un compo- nente fundamental en los sistemas ganaderos de la Patagonia, debido a que repre- sentan la principal fuente de forraje a nivel predial. La hipótesis de trabajo es que, la generación de conocimiento acerca de la diversidad florística y productividad de los distintos tipos de vegas presentes en Magallanes, propiciará un manejo ganadero sustentable de éstas, lo cual, a su vez, garantizará la conservación de las funciones y los servicios ecosistémicos de las vegas. Entre enero de 2019 y mayo 2020, se realizó un estudio en seis estancias de la Isla de Tierra del Fuego, Chile, para describir los componentes taxonómicos, comparar la diversidad de especies de plantas, evaluar la similitud florística, junto con analizar la distribución temporal de la biomasa vegetal a la exclusión de la herbivoría que caracterizan a dichos ecosistemas. Se registraron un total de 53 taxones, distribuidos en 16 familias (Poaceae, Rosaceae, Cyperaceae, Apiaceae y Asteraceae, principalmente) y 40 géneros, de las cuales 40 especies son nativas y 11 introducidas para las vegas. Los sitios analizados presentaron valores de riqueza específica e índices de diversidad menores a los encontrados en Patagonia Argentina. La composición florística y los atributos de la vegetación mostraron patrones vinculados al contenido hídrico del suelo, observándose una relación negativa entre el nivel freático y los valores de riqueza e índices de diversidad. Respecto a cobertura vegetal, los sectores húmedos presentaron porcentajes de cobertura vegetal mayores a los de los sectores semihúmedos. Finalmente, se determinó que las vegas no son homogéneas en su composición de especies, ni en su estructura, estas muestran evidencias de cambios en su diversidad florística, debido a los impactos generados por la intensidad del pastoreo, el cual se refleja en producción de forraje, fluctuando entre 408 a 4.055 kg MS ha-1
Lo que va del labrador al campesino: representaciones sociales en el actual territorio colombiano, 1780-1866
Authors: Robledo Escobar Natalia , Langebaek Rueda Carl Henrik
Published: January 2022

El artículo aborda, desde una perspectiva cualitativa y antropológica, las representacionessociales sobre los agricultores entre 1780 y 1866 por parte de funcionarios peninsulares, élites letradas y autores costumbristas. Se argumenta que la Independencia propició una ruptura en dichas representaciones, lo cual se reflejó en el paso de labrador a campesino como término de uso predominante. Si bien estos compartieron buena parte de sus supuestos defectos, a los campesinos se les atribuyó un papel más positivo en el futuro del país. La mirada más benigna hacia los campesinos los hizo funcionales a la construcción de la nueva nación y permitió que se dieran pasos tendientes a considerarlos un elemento importante de la identidad nacional.
COLLABORATIVE LEARNING THROUGH LESSON STUDY IN PMRI TRAINING FOR PRIMARY SCHOOL PRE-SERVICE TEACHER: THE SIMULATION OF POLYGON MATTER
Authors: Fauziah Anna , Putri Ratu Ilma Indra , Zulkardi Zulkardi
Published: January 2022

Collaborative learning through lesson study has become one of the promising methods for improving the quality of education and improving teachers' quality, likewise with the PMRI approach. The combination of the two in the training for primary school pre-service teachers, specifically in the second simulation session, was observed and reported. This article aims to describe the collaboration process in the second session of the simulations about polygon learning at PMRI training for primary school pre-service teachers. A design research method of the development type was used in this study, only at the preliminary and development or prototyping phase. The research subjects are students of Primary School Pre-service Teachers of Sriwijaya University that consisted of eight students for the small group and 32 students for the field test. Data was collected through documentation, observation, and field notes. The result showed that there were good collaboration occurs between researcher-lecturer, lecturer-student, and between students at the plan-do-see-redesign stage of the lesson study.
Atenção farmacêutica à gestantes portadoras de pré-eclâmpsia
Authors: Sousa Vanessa Pereira , Franqueiro Elaine de Paula Mendonça , Bragança Cléria , Mendonça Guilherme Silva de
Published: January 2022

Resumo: O presente estudo tem como principal objetivo relatar a importância do cuidado farmacêutico nas pacientes com pré-eclampsia na gestação. Esta doença tem como característica, concomitantemente, a hipertensão arterial sistêmica, edema e proteinúria. A metodologia foi a de revisão bibliográfica em sites da Pubmed e SciELO. Entre os resultados, observou-se que a pré-eclampsia tipo leve acomete a maioria dos casos, sendo em média 30% os casos graves. A prevenção da progressão da doença se dá por meio de medicamentos como hidralazina, metildopa e nifedipino, incluindo sulfato de magnésio para a prevenção de crises convulsivas e o parto representa a cura da doença. Na tentativa de melhorar ou prevenir a enfermidade a Atenção Farmacêutica, uma prática exclusiva do profissional farmacêutico, contribui para que os níveis pressóricos sejam controlados, devido à utilização da farmacoterapia correta, para que assim se possa prevenir o desenvolvimento da doença e obter um prognóstico favorável da gestação.
Educação em saúde abordando tema “dengue” de forma interprofissional: relato de experiência
Authors: Banhos Cathiana do Carmo Dalto , Farias Maria Letícia Almeida , Santos Andressa de Jesus , Sodré Maira Motta Passos Costa , De Souza Magna Paris Magnago
Published: January 2022

O objetivo principal é relatar a experiência em ação de Educação em Saúde com adultos, discutindo o tema dengue, orientando e conscientizando comunidades no município de São Mateus, ES. A intervenção foi elaborada pelo projeto NN, sendo incluída ao calendário de atividades de duas Unidades de Estratégia de Saúde da Família, intitulado “Dia D” (Dia de mobilização relacionado à Hipertensão e Diabetes) com objetivo de promover educação e prevenção da doença por meio da interrupção da cadeia de transmissão. Foram utilizadas técnicas inclusivas a fim de promover a interação da comunidade na troca de saberes. A população demonstrou participação efetiva e interesse, evidenciando os casos notificados e confirmados dentro da comunidade. Isso desencadeou uma maior reflexão que acarretou uma mobilização para a limpeza do bairro. Desta maneira, contribuíram no controle social e no engajamento de práticas de prevenção e promoção de saúde.
Colonização nasal e em orofaringe por Staphylococcus aureus em crianças e adolescentes de um bairro do município de Vitória da Conquista, Bahia, Brasil
Authors: Dos Santos Jefferson Nilton Silva , Alves Sabrina Santos , Novais André Brito , Vieira Verônica Cheles , Dos Santos Milena Soares
Published: January 2022

Staphylococcus aureus é uma bactéria Gram-positiva que habita a cavidade nasal de cerca de 30% da população saudável. A resistência aos antimicrobianos tem emergido na comunidade e se tornado uma preocupação global. O objetivo deste estudo é determinar prevalência de colonização nasal e de orofaringe causada por este patógeno em crianças e adolescentes saudáveis de uma comunidade na cidade de Vitória da Conquista, Bahia e avaliar a frequência de isolados resistentes aos antimicrobianos. Trata-se de estudo transversal, conduzido através de investigação epidemiológica e laboratorial a partir de entrevistas e obtenção de swabs de secreção nasal e de orofaringe. A identificação microbiológica foi realizada por métodos convencionais e o perfil de susceptibilidade antimicrobiana por disco-difusão. O programa EpiInfo Windows versão 3.5.4 foi utilizado para análise estatística dos dados. Identificou-se prevalência de 73,1% para colonização por S.aureus em amostra nasal e/ou orofaringe e de 31,2% em ambos os sítios anatômicos. Entre os isolados de amostra nasal, 26,7% apresentaram resistência a pelo menos um antimicrobiano e 6,7% foram resistentes à meticilina. Para amostras de orofaringe, identificou-se 35,3% de não susceptibilidade à eritromicina. Foi observada alta taxa de colonização nasal e orofaríngea por S. aureus entre os participantes analisados. Dessa forma, destacamos a importância do contínuo monitoramento deste patógeno e de suas variantes resistentes na comunidade.
Tricyclic antipsychotics and antidepressants can inhibit α5-containing GABAA receptors by two distinct mechanisms
Authors: Bampali Konstantina , Koniuszewski Filip , Silva Luca , Rehman Sabah , Vogel Florian , Seidel Thomas , Scholze Petra , Zirpel Florian , Garon Arthur , Langer Thierry , Willeit Matthäus , Ernst Margot
Published: January 2022

Background and Purpose: Many psychotherapeutic drugs, including
clozapine, display polypharmacology and act on GABA
receptors. Patients with schizophrenia show alterations in function,
structure and molecular composition of the hippocampus, and a recent
study demonstrated aberrant levels of hippocampal a5 subunit-containing
GABA receptors. The purpose of this study is to
investigate tricyclic compounds in a5 subunit-containing receptor
subtypes.

Experimental Approach: Functional studies of effects by seven
antipsychotic and antidepressant medications were performed in several
GABA receptor subtypes by two‐electrode voltage‐clamp
electrophysiology using Xenopus laevis oocytes. Computational
structural analysis was employed to design mutated constructs of the a5
subunit, probing a novel binding site. Radioligand displacement data
complemented the functional and mutational findings.

Key Results: We show that the antipsychotic drugs clozapine and
chlorpromazine exert functional inhibition on multiple
GABA receptor subtypes, including a5-containing ones.
Based on a chlorpromazine binding site observed in a GABA-gated
bacterial homologue, we identified a novel site in a5
GABA receptor subunits and demonstrate differential
usage of this and the orthosteric sites by these ligands.

Conclusion and Implications: Despite high molecular and
functional similarities among the tested ligands, they reduce GABA
currents by differential usage of allosteric and orthosteric sites. The
C C C C C C site we describe here is a new potential target for
optimizing antipsychotic medications with beneficial polypharmacology.
Further studies in defined subtypes are needed to substantiate
mechanistic links between the therapeutic effects of clozapine and its
action on certain GABA receptor subtypes.
Hematologic manifestations of SARS-CoV-2 infection and MIS-C in hospitalized children. Results of the PICNIC registry.
Authors: Tehseen Sarah , Williams Suzan , Robinson Joan , Morris Shaun , Tal Tala , Bitnun Ari , Gill Peter , Yeh Ann , Yea Carmen , Brenes Helena , Yock-Corrales Adrianna , Nuevo Rolando , Ivankovich-Esctoto Gabriela , Fallas Alejandra , Papenburg Jesse , Lefebvre Marie-Astrid , Scuccimarri Rosie , Nateghian Alireza , Aski Behzad , Dwilow Rachel , Bullard Jared , Restivo Leo , Cooke Suzette , Lopez Alison , Roberts Ashley , Sadarangani Manish , Forbes Michelle Barton , Saux Nicole , Bowes Jennifer , Purewal Rupeena , Lautermilch Janell , Bayliss Ann , Wong Jacqueline , Leifso Kirk , Foo Cheryl , Panetta Luc , Kakkar Fatima , Piche Dominique , Viel-Theriault Isabelle , Merckx Joanna , Lieberman Lani
Published: January 2022

Introduction: Hematologic complications of SARS-CoV-2 infection are well
described in hospitalized adults with correlation to adverse outcomes.
Information published in children has been limited. Methods: An
international multi-centered retrospective registry was established to
collect data on the clinical manifestations of SARS-CoV-2 or multisystem
inflammatory syndrome (MIS-C) in hospitalized children between February
1, 2020 – May 31, 2021. This sub-study focused on hematologic
manifestations. Study variables included patient demographics,
comorbidities, clinical presentation, course, laboratory parameters,
management, and outcomes. Results: Nine hundred and eighty-five children
were enrolled and 915 (93%) had clinical information available; 385
(42%) had symptomatic SARS-CoV-2 infection upon admission, 288 had
MIS-C (31.4%) and 242 (26.4%) had alternate diagnosis with SARS-CoV-2
identified incidentally. During hospitalization, 10 children (1%)
experienced a thrombotic event, 16 (1.7%) had hemorrhage and 2 (0.2%)
had both thrombotic and hemorrhagic episodes. Significant prothrombotic
comorbidities included congenital heart disease (p-value = 0.007),
central venous catheter (p = 0.04) in children with primary SARS-CoV-2
infection; and obesity (p-value= 0.002), cytokine storm (p= 0.012) in
those with MIS-C. Significant pro- hemorrhagic conditions included age
> 10 years (p = 0.04), CVC (p= 0.03) in children with
primary SARS-CoV-2infection; and thrombocytopenia (0.001), cytokine
storm (0.02) in those with MIS-C. Eleven patients died (1.2 %) with no
deaths attributed to thrombosis or hemorrhage Conclusion: Thrombotic and
hemorrhagic complications are uncommon in children with SARS-CoV-2
infection and observed with underlying co-morbid conditions.
Understanding the complete spectrum of hematologic complications in
children with SARS-CoV-2 infection or MIS-C requires ongoing
multi-center studies.
dnabarcoder: an open-source software package for analyzing and predicting DNA sequence similarity cut-offs for fungal sequence identification
Authors: Vu Duong , Nilsson Henrik , Verkley Gerard
Published: January 2022

The accuracy and precision of fungal molecular identification and
classification are challenging, particularly in environmental
metabarcoding approaches as these often trade accuracy for efficiency
given the large data volumes at hand. In most ecological studies, only a
single similarity cut-off value is used for sequence identification.
This is not sufficient since the most commonly used DNA markers are
known to vary widely in terms of inter- and intra-specific variability.
We address this problem by presenting a new tool, dnabarcoder, to
analyze and predict different local similarity cut-offs for sequence
identification for different clades of fungi. For each similarity
cut-off in a clade, a confidence measure is computed to evaluate the
resolving power of the genetic marker in that clade. Experimental
results showed that when analyzing a recently released filamentous
fungal ITS DNA barcode dataset of CBS strains from the Westerdijk Fungal
Biodiversity Institute, the predicted local similarity cut-offs varied
immensely between the clades of the dataset. In addition, most of them
had a higher confidence measure than the global similarity cut-off
predicted for the whole dataset. When classifying a large public fungal
ITS dataset – the UNITE database - against the barcode dataset, the
local similarity cut-offs assigned fewer sequences than the traditional
cut-offs used in metabarcoding studies. However, the obtained accuracy
and precision were significantly improved.
Mepolizumab -- therapeutic strategy for a paediatric patient with eosinophilic granulomatosis with polyangiitis
Authors: Ozola Lota , Aleksejeva Elīna , Stoldere Diāna , Grantiņa Ineta , Dāvidsone Zane , Šantere Ruta , Cīrule Ieva , Krams Alvils
Published: January 2022

Eosinophilic granulomatosis with polyangiitis (EGPA; formerly known as
Churg-Strauss syndrome) is classified as an anti-neutrophil cytoplasmic
antibody (ANCA)-associated small vessel vasculitis. It is a multisystem
disorder and can affect every organ system. EGPA is a rare disease, with
an estimated prevalence of 1/70,000–100,000 in Europe. As its onset
usually occurs in adulthood, data from paediatric patients are limited.
We present here a very rare practical EGPA clinical case involving a
paediatric patient. Presently, data on mepolizumab usage in paediatric
patients are limited, with only a few case reports published.
Metaphysical settings of architecture according to the theо-anthropocentric paradigm of Justin Popovic
Authors: Stevanovic Slaven
Published: January 2022

The basic truths of architecture have been forgotten. This paper searches for
the solution in the knowledge of metaphysical settings of architecture. More
precisely, the metaphysical aspects of ontology, gnoseology, axiology and
methodology; which together represent the basic criteria of a scientific
paradigm. The initial question must be gnoseological, i.e. - what is the
raison d??tre of architecture? The analysis leads to an assumption that
without knowing the metaphysics of man there can be no knowledge of the
metaphysics of architecture; that is, a conclusion can be drawn that the
problem of metaphysic of man in architecture has not been posed. Therefore,
man must be the main issue of architecture, as well as of this paper. Given
that the problem of knowledge in general sense, and therefore of man, is
also of theological and philosophical nature, in this paper, the problem of
man is understood as a gnoseological choice; namely: the choice between man
as man-god (man is the source of knowledge) and man as god-man (God is the
source of knowledge). Respectively, there is a choice between historical
antipodes, the paradigm of anthropo-theocentrism and the paradigm of
theo-anthropocentrism. In this paper, I argue that the issue of god-man and
the paradigm of Orthodox theoanthropocentrism, as interpreted by Justin
Popovic, is potentially the most comprehensive solution to the problem of
raison d??tre of man, and architecture that he creates. Discussion and
analysis have established that, in this pattern, man is seen as a holistic,
spiritual and physical entity, whose primary need to be met and his raison
d??tre - is deification. Thereby, architecture of orthodox
theo-anthropocentrism acquires not only a physical, but also a spiritual,
and thus, a holistic dimension. It may represent a symbolic means (through
sensory and primarily visual representation) of man?s ascension to God.
Theo-anthropocentric paradigm solves the metaphysical foundations and
potentially forms more holistically organized architecture that meets the
equally holistic, spiritual and physical, needs of man. Its material
manifestation is determined by only one criterion - deification.
“Karadjordjev dom” in Raca: Taking the first steps of cultural property rehabilitation process
Authors: Vasic-Petrovic Elena
Published: January 2022

"Karadjordjev dom" in Raca, a monumental building, protected as a cultural
monument, whose construction was completed in 1933, after many years of use
and several changes of purpose, has been abandoned since 2016 and is now
awaiting its first renovation. The rehabilitation project, started on the
initiative of the municipality of Raca, envisages numerous activities in
order to prevent its further degradation and to reconsider the possibilities
for its revival, adequate presentation and permanent protection. The paper
presents the first concrete steps realized during 2020.
Performance of asphalt mixtures with a new type of rubber modified bitumen
Authors: Almássy Kornel , Geiger András , Holló András , Gáspár László
Published: January 2022

The rubber modified bitumen 45/80-55 (RMB 45/80-55) product has been used in
Hungary as bituminous binder for asphalt mix production since 2013. It is a
new kind of rubber bitumen manufactured using patented technology. Over the
past 8 years, it has been used to construct or renovate more than 100
asphalt road sections. Originally RMB 45/80-55 was used to replace paving
grade bitumen 50/70 in some road construction projects. However, asphalt
laboratory results and road construction experience showed that its quality
can also achieve or in terms of some parameters exceed that of asphalt
mixtures manufactured with polymer modified bitumen 25/55-65 (PMB 25/55-65).
Primarily, its excellent resistance to low temperatures and fatigue are
outstanding, in this respect; it surpasses the results of asphalts made with
polymer modified bitumen. Its favourable fatigue resistance compensates for
its lower stiffness; therefore, favourable results were obtained in the case
of track structure design too in comparison with PMB. Considering the road
construction benefits of this new type of rubber bitumen, as well as the
support of the environmentally friendly recovery of waste tyres and fitting
into a circular economy, a wider spread of the RMB product is realistically
expected in the future.
Team-based rehabilitation after traumatic brain injury: a qualitative synthesis of evidence of experiences of the rehabilitation process
Authors: Larsson-Lund Maria , Pettersson Agneta , Strandberg Thomas
Published: January 2022

Objective: To synthesize and explore experiences of the rehabilitation process for adults with traumatic brain injury receiving team-based rehabilitation.Data sources: A qualitative evidence synthesis was conducted according to the “Enhancing transparency in reporting the synthesis of qualitative research” (ENTREQ) Guidelines, of qualitative studies published in 5 databases in 2000–21.Study selection and data extraction: Screening, selection of relevant studies, assessment of methodological limitations, systematic qualitative content analysis and assessment of confidence with Grading of Recommendations Assessment, Development, and Evaluation- Confidence in the Evidence from Reviews of Qualitative research (GRADE-CERQual) were carried out by independent researchers.Data synthesis: The 10 included studies revealed how people with traumatic brain injury perceived that they struggled on their own for a long time to adapt their daily life. They experienced that access to team-based rehabilitation was scarce and that the interventions offered were neither individually tailored nor coordinated. A respectful attitude from professionals and individually adapted information facilitated their rehabilitation process.Conclusion: This qualitative evidence synthesis indicates areas for improvement and a need to develop person-centred team-based rehabilitation for adults with traumatic brain injury, in terms of accessibility, coordination, continuity, content and participation. Given the limited opportunities for team-based rehabilitation after hospital discharge, further research is needed to understand how rehabilitation can support the adaptation of everyday life.
Lay abstractThe aim of this study was to review scientific publications about experiences of the rehabilitation process from the perspective of adults with traumatic brain injury who had received team-based rehabilitation. Several established databases were searched, yielding 10 relevant qualitative studies. The experiences described in these studies overlapped, and showed that people with traumatic brain injury struggled on their own over a long period of time to adapt to their new situation in everyday life. They experienced that access to team-based rehabilitation was limited and not adapted to their needs at different time-points. As many people with traumatic brain injury had limited experience of team-based rehabilitation after hospital discharge, this study indicates a need to develop person-centred team-based rehabilitation over a longer period of time. Further research is needed regarding experiences of how rehabilitation can support adaptation in everyday life after traumatic brain injury.
Masculinities, vulnerability and negotiated identity: Understanding the reporting behaviours of men who experience violence or otherwise harmful behaviour, within a sex work context
Authors:   , Dawson Jordan L.
Published: January 2022

Context The focus of sex work related discussions most commonly falls on female providers of sexual services, and male purchasers. As a result, the often victim-oriented policy response in England and Wales falls short of truly addressing the needs of men who are involved in the sale of sex, with there being limited support available for them and a systemic approach which does not fully recognise the potential for men to face harm within this context. Methods The aim of this study is to explore experiences of and reactions to violence, and otherwise harmful behaviours, faced by men in the context of their sex working, by understanding the lived realities of a sample of men who engage in this type of work. The study takes a phased approach which combines an initial informative quantitative survey, with three subsequent phases of semi-structured interviews with male sex workers, sex work-focused practitioners and police officers. The method is guided by feminist research principles which suggest that reality is situated within those with lived experience, and also by an element of co-creation which has grounded this study within the perspectives of male sex workers from its conception. Findings The findings of this research suggest that all of the men involved in the study had faced at least one of the violent or otherwise harmful behaviours outlined, though reporting of these behaviours was not at all common. Discussions with the male sex working participants, practitioners and the police highlighted the issues related to the structural influences of authority, such as the police, and the social environment, and the internalisation of these wider factors, which create barriers to reporting for groups such as male sex workers and others who face similar social marginalisation. Conclusions This study challenges existing gendered understandings of violence and otherwise harmful behaviour within a sex work context, by highlighting the harmful experiences of men. By exploring these experiences and the reporting behaviours of those involved, the study also proposes a new framework for understanding barriers to reporting, which suggests that these are formed through the influences of formal and informal measures of social control, and the internalisation of these outside influences by the individual. By better understanding the experiences of men, and the barriers to their reporting, this study attempts to nuance a gendered discussion. Within, I propose that in order to better support male sex workers, responses must begin by appreciating the heterogeneity of those involved in sex work and the influence of their individual circumstances and the social environment on their willingness to seek support.
FAKTOR PENYEBAB KESALAHAN SISWA SMK DALAM MENYELESAIKAN SOAL CERITA PADA MATERI PELUANG
Authors: Astuti Windi Ria , Noerhasmalina Noerhasmalina , Khasanah Binti Anisaul
Published: January 2022

It is not easy for students to understand the questions in the form of stories so that errors often occur in the process of solving problems. This study aims to describe the factors that cause vocational students' errors in solving story problems based on Anne Newman. This research is a qualitative research. The instrument used in this research is a test which consists of 3 questions and an interview guide. The subjects in this study were students of class XII TKJ SMK Patria Gadingrejo. Analysis of the data using the analysis of the location of student errors based on Anne Newman's procedure, namely a) reading the problem, understanding the problem, b) transforming the problem, c) process skills, and d) writing the final answer. The factors that cause student errors at each stage are: 1) misunderstood the problem, the cause of which is the lack of understanding and thoroughness of students; 2) problem transformation errors, the reason is that students do not master the concept and do not have mastery of the material; 3) process skill errors, the cause of which students are wrong in doing the initial steps of work; 4) errors in writing the final answer, the reason is that students are not accustomed to writing conclusions.
DESAIN MEDIA PEMBELAJARAN MATEMATIKA TOPIK FAKTOR PERSEKUTUAN TERBESAR (FPB) BERBASIS APLIKASI SCRATCH
Authors: Sudihartinih Eyus , Wilujeng Sekar , Rachmatin Dewi
Published: January 2022

The purpose of this study was to describe the results of research on the design of Scratch-based learning media on the topic of the Greatest Commonwealth Factor (FPB). This study uses the Multimedia Development Life Cycle (MDLC) development model through six stages, namely concept, design, collecting, assembly, testing, and distribution. Furthermore, to find out the student's response to the media that has been designed so that a research instrument is used in the form of a questionnaire via Google Form and given in 2021. Research participants are students at one of the junior high schools in the city of Bekasi, West Java. Based on the results of the study, it is known that the learning media for the topic of FPB mathematics can be well designed through the MDLC development model through six stages. In addition, it is known that the student's response to the media that has been designed is positive. Thus the need for further research including game design on different topics.