bluuebunny/crossref_metadata_2025 huggingface dataset:
construção da identidade cultural no artesanato para o desenvolvimento sustentável do saber-fazer
Authors: Narciso Vaneza Pereira , Borges Andrea Jaqueira da Silva , Sales Marcos Paulo
Published: May 2023

A identidade cultural tornou-se um elemento distintivo no processo de produção artesanal, no entanto, observa-se que há tensões entre a construção de tal identidade e os processos de “sustentabilidade” do saber-fazer. Assim, este artigo teve como objetivo verificar, através de uma revisão integrativa, os elementos que fazem parte da construção identitária do saberfazer da renda de bilro e a relação com o desenvolvimento sustentável da produção artesanal. Metodologicamente, trata-se de uma pesquisa bibliográfica, do tipo revisão de literatura integrativa. Para coleta das informações, foram utilizados trabalhos científicos encontrados em repositórios das instituições de ensino superior da Bahia, avaliadas e recomendadas pelaCoordenação de Aperfeiçoamento de Pessoal de Nível Superior do Conselho Nacional de Desenvolvimento Científico e Tecnológico, dentro do recorte temporal de 2001 a setembro de 2022. Foram selecionados trabalhos cujo objeto de estudo trata da produção artesanal da renda de bilro na comunidade de Saubara, Recôncavo da Bahia, Brasil. Como resultados obtidos, foi possível identificar que, nas publicações analisadas, as tensões encontradas naconstrução identitária do artesanato são referentes às fragilidades das relações sociais entre as artesãs e a comunidade.
Management of Henoch-Schonlein Purpura with Gastrointestinal Manifestations in Children
Authors: Wardhani Rizki Luthfia , Saroh Siti Ariffatus
Published: May 2023

Henoch-Schonlein Purpura (HSP) is systemic vasculitis in children, hallmark by inflammatory infiltration of polymonuclear leukocytes in small blood vessels, followed by IgA1 immune deposits. HSP prevalence is approximately 3-27 cases per 100,000 children. The inflammatory process in HSP causes an ischemia and hemorrhagic process characterized by non-thrombocytopenia purpura, arthralgia, gastrointestinal problems, and kidney impairment. This process is called leukocytoclastic vasculitis. A 10-year-old boy came to ER of Dr. Sayidiman Magetan Hospital presenting with diffuse abdominal pain and purpura skin lesions in body. The complaint started with a red rash on both legs, then progressively extended to both hands, thighs, and buttocks, and continued with severe abdominal discomfort, nausea, dizziness, fever, and the patient also experienced a brownish-black stool. The patient was diagnosed with Henoch-Schonlein purpura with gastrointestinal manifestations based on medical examination. The patient stayed for six days at the hospital, and the condition improved.
The Search for Potential SARS-CoV-2 Inhibitors Using the In Silico Research
Authors: Suleiman Marharyta M. , Fedosov Andrii I. , Mohapatra Ranjan K. , Sych Irina A. , Grinevich Lina O. , Kobzar Nataliia P. , Yaremenko Vitaliy D. , Perekhoda Lina O.
Published: May 2023

Aim. Using in silico technologies to search for potential SARS-CoV-2 inhibitors among novel tetracyclic ring systems, which are the common core of Crinipellin.Materials and methods. The study object was new compounds previously synthesized via oxidative dearomatization of Crinipellin A. The method of the flexible molecular docking was applied in the study.Results and discussion. Using the molecular docking, the affinity of five compounds for the receptor-ACE2 SARS-CoV-2 (PDB ID: 7DF4), a spike protein SARS-CoV-2 (PDB ID: 1WNC), a PL protein SARS-CoV-2 (PDB ID: 7CJD) and a reverse transcriptase enzyme SARSCoV-2 (PDB ID: 6YYT) was studied. The results of the molecular docking obtained suggest that 8,8-dimethyl-5-(phenylsulfonyl)-3,3a,4,5,8,9-hexahydroindeno[3a,4-b]furan-2(7H)-one may be a potential SARS-CoV-2 inhibitor; it is the basis for its further experimental pharmacological study.Conclusions. The study constitutes one of the stages of searching for SARS-CoV-2 inhibitors. According to the results obtained, a way to search for potential SARS-COV-2 inhibitors based on Crinipellin A derivatives was proposed. Using the most promising compound with hexahydroindeno[3a,4-b]furan core further studies open up another direction for searching for compounds of SARS-COV-2 inhibitors and will save time and laboratory animals while conducting targeted experimental research.
Bioethics aspects in the prevention of vertical transmission and management of treatment with antiretrovirals in pennants infected with HIV/AIDS in Brazil
Authors: Fernandes Cristiane
Published: May 2023

In 2012, the United Nations Organization together with the World Health Organization reported that by the end of 2011 there would be about 34 million infected with the human immunodeficiency virus worldwide. Among other forms, the vertical transmission has been a focus of attention in the sense that there has been an increase in cases of infection in women. In this context, this study aims to present antiretroviral treatment in pregnant women with HIV/AIDS, as well as to discuss the bioethical aspects related to the prevention of vertical transmission. In 1994, protocol 076 showed that the use of zidovudine in pregnant women who had the virus during prenatal and childbirth and in the baby during the first six weeks of life, reduced the transmission of the virus by 2/3 for children. Subsequently, the Ministry of Health adopted measures to reduce the incidence of vertical transmission. Nowadays the doctor can make use of guidelines and must use the treatments available for the good of the patients, according to their capacity and judgment, according to the hippocratic tradition, provided that are adequately measured the risks that such medicines can promote to the pregnant woman and to the baby.
Evaluation of acute events hospital admissions in sickle cell disease pediatric patients at a reference center in Salvador, BA
Authors: Lyra Isa , Siqueira Humberto , Menezes Vitor
Published: May 2023

OBJECTIVES: Identify the main causes of hospital admissions of patients less than 18 years old with sickle cell disease (SCD) in a reference hospital of Salvador, BA and describe the sociodemographic profile, cost and duration of admission and outpatient follow-up in our sample. METHODS: Cross-sectional study of admissions of patients of less than 18 years old with SCD (IDC D57.0, D57.1, D57.2, D57.8) from January 2013 to June 2018, at a reference hospital in Salvador, BA. Clinical and demographic variables were extracted from patient charts, such as gender, age, hemoglobin genotype, admission cause and cost. Data was analyzed using descriptive statistics and hypothesis testing with chi-square, Students t, Mann-Whitney and Fishers exact test using the Statistical Package for the Social Sciences v. 23.0. Research was aproved by the ethics and research committee for human beings research of Obras Sociais Irmã Dulce. RESULTS: 53 admissions were analyzed, with vaso oclusive event as the main cause (20-37.7%), followed by infection (15-28.3%) and acute thoracic syndrome (8-15.1%). 23 (73.58%) of admissions happened in the first decade of life (p=0,008). Only 4 (7.5%) of patients used hydroxiurea. 45.3% admissions happened in the fall and 11.3% in spring (p=0,04). CONCLUSION: Despite the inversion of the main causes of hospitalization, they are still the most prevalent, reinforcing the possibility of need for better adherence to prophylactic measures and better access to outpatient treatment with hydroxyurea in structured and well-distributed network.
COVID-19 in a neonate with congenital heart disease: case report
Authors: Souza Paula , Peixoto Fernanda , Botacin Lais , Avelino Melissa
Published: May 2023

On March 11, 2020, the World Health Organization pandemiced the COVID-19. Currently in Brazil, more specifically in the midwest region, the pandemic is at the peak of the curve of new cases, including among neonates, who introduce clinical manifestations different from those previously reported in other age groups, rarely requiring hospitalization in an intensive care unit due to a multisystemic condition, which came to be called the pediatric multisystemic inflammatory syndrome (MIS) related to COVID-19. In this report, the authors demonstrate the case of a newborn with congenital heart disease, with a rare unfavorable evolution after infection by sars-cov-2 in the first days of life.
TINGKAT POTENSI OBJEK WISATA ALAM DI KOTA SORONG
Authors: Marau Andri Krisno , Wiranegara H W , Taki Herika M.
Published: May 2023

Information on the city tourism potential is important in city development so that the contribution of the tourism sector is clear. Sorong City is the second largest city on the island of Papua which is very strategically located and has several natural tourist objects but its potential is unknown. This study aims to identify potential tourist objects in Sorong City. This study uses a quantitative approach. The potential for tourism objects is viewed from the aspects of tourist attraction, accommodation, facilities and infrastructure, and accessibility. Analysis of the potential for tourism objects uses assessment criteria based on the Guidelines for Analysis of Operational Areas for Natural Tourism Objects and Attractions (ADO – ODTWA). The results of the study show that the potential for natural tourism objects in Sorong City is at a potential level to be developed according to these guidelines.
PEMILIHAN KELURAHAN CALON LOKASI TPU DI JAKARTA
Authors: Caisario Kevin Yosua , Wiranegara H W , Taki Herika Muhamad
Published: May 2023

DKI Jakarta experienced a public cemetery (TPU) land crisis during covid-19 which caused 3 (three) overcapacity TPU lands (DKI Jakarta Provincial Government, 2021). The need for TPU is increasing, causing problems such as a shortage of grave land. In overcoming this problem, a plan for selecting a new TPU location is needed, considering the land crisis can be minimized and the community's need for public burial places is still met. The DKI Jakarta Spatial Planning & Zoning Pattern designates 97 sub-districts to become TPU land developments. In choosing the location of the new TPU, a structured research method is needed, so that among these 97 sub-districts the best location can be chosen, in selecting the right location by using the map overlay analysis method (arcGIS). The stages of selecting the location of the new TPU use criteria, namely, the use of vacant land, the slope of the slope, the radius of the settlement which will be tested simultaneously in 97 urban villages. The results of this study selected 3 sub-districts to be the location of the new TPU, namely Rorotan, Grinding and Rawa Terate Villages. This selected sub-district has an area of +10 ha of vacant land, has a minimum radius of 500m from the settlement and a suitable slope
PENGOLAHAN LIMBAH CAIR DENGAN LUMPUR AKTIF AEROBIK: STUDI KASUS INDUSTRI MINUMAN
Authors: Halim Abdul , Kurniawan Iqbal , Sari Irliana Mai , Sapitri Wulan Dari
Published: May 2023

Problems with the aquatic environment can become a serious problem if it is linked to population growth and the manufacturing industry in Indonesia, which also means the increasing volume of wastewater originating from settlements and industrial areas. If not handled properly, wastewater problems can become a potential threat to the quality of a water and become a serious threat as a cause of water pollution. Nearly 60% - 70% of the air used will be wasted as wastewater which will generally enter water bodies without prior treatment efforts, thus contributing to pollution in water bodies. The purpose of this research is to evaluate alternative waste treatment conditions using activated sludge so that can determine the effectiveness of the method on decreasing test parameters such as COD, TSS, and pH stability. Data was collected using a lab-scale check that lasted 6 months with 4 research stages. The results showed the ability of aerobic bacteria in activated sludge to reduce the content of test parameters in liquid waste so that the end result follows the Industrial Liquid Waste Quality Standard according to applicable laws and regulations.
Key Success Factors for a Workplace Skills Plan: A Case of a Developing Country
Authors: Van der Westhuizen Thea , Shange Proctus Lucky
Published: May 2023

Questions have been raised by organisations such as the South African Department of Education regarding the value of the investment made towards employees in respect of the implementation of a workplace skills plan in their organisations. A further question pertains to the levels of competencies of human resource officials, who are often saddled with the responsibility of implementing a workplace skills plan in their organisation. In this article, we focus on the role of strategic human resource management across the implementation of a workplace skills plan throughout the twenty-first century to improve the performance of organisations in developing countries. The recent advances in the structure of organisations demand robust employee development, especially regarding role players who are involved in the implementation of a workplace skills plan for the improved performance of their organisations. We conducted and investigated a quantitative analysis of an existing structure for development and implementation of a workplace skills plan in the Limpopo Department of Education with regard to its adoption and performance. A total of 75 managers were sampled through probability sampling based on data gathered from the Limpopo Department of Education which indicated a population size of 1 019 managers. In the study, we provide insights for organisations into implementing a workplace skills plan in public sectors, identifies bottlenecks encountered in the process of implementation, and propose strategies that can be employed to overcome relevant challenges.
Organisational Effectiveness in a Metropolitan Municipality: Proposing and Validating a Model
Authors: Olivier Benny , Martins Nico
Published: May 2023

The aim of this study was to propose and validate a model of organisational effectiveness which could be utilised by a metropolitan municipality to address problems and weaknesses in order to maintain its credibility in the eyes of the public and fulfil its legislatively prescribed mandate. As a first step, this study designed a conceptual model of organisational effectiveness for a metropolitan municipality by including organisational and behavioural variables published in previous studies, as well as variables contained in existing models of effectiveness. In order to validate the model, the next step was to conduct a cross-sectional survey using the Effectiveness Survey (ES) in an existing metropolitan municipality in South Africa (n = 6 514) and expose the data gathered to structural equation modelling (SEM). The confirmatory factor analysis that was conducted subsequently confirmed the existence of the three main variables proposed in the conceptual model, namely Healthy Systems, Goal Achievement and Service Delivery, but did not support all the hypothesised relationships between these variables. The implications of the statistically significant and insignificant relationships obtained are discussed and the utility of SEM as a means of validating a conceptual model is confirmed
Leader-Member Exchange (LMX) Impact on Work-Home Interference in a South African Commuter Transport Engineering Company
Authors: Visagie Jan Christoff , Jones Michael M. , Linde Herman L.
Published: May 2023

The South African workplace is confronted with many leadership challenges, specifically those relating to the employment relationship between subordinates and their supervisors. A high-quality relationship is essential, considering the work-family spillovers employees experience. Limited research has been conducted on the potential positive and negative consequences of the leader-member exchange (LMX) dyadic relationship. In this study, we used a cross-sectional research design, and drew an employee sample (N = 120) from a commuter transport engineering company. A five-point Likert scale was employed and statistical analyses were carried out using the SAS statistical program. We calculated Pearson correlation coefficients and used structural equation modelling to test the proposed conceptual model to indicate possible correlations between the different variables. The main finding of the study was that the nature of the LMX relationship quality in the relevant company appeared to be high and positively related to work-home enrichment but negatively related to work-home conflict and role overload. The article concludes by making a number of suggestions to respond to challenges.
Labour Legislation Compliance within the Small-Enterprise Sector
Authors: Luvhengo Nkhuliseni Elijah , Thomas Adele
Published: May 2023

The purpose of this study was to investigate how compliance with labour law—particularly the Labour Relations Act (LRA) and the Basic Conditions of Employment Act (BCEA)—could be promoted as sound governance practice. The study adopted a qualitative approach, and eight experts in the field were purposefully sampled and interviewed. The results suggested that small-enterprise owners were not knowledgeable about labour laws, hence their inability to comply with them. It was found that owners experienced labour laws as cumbersome, and their forced implementation had a negative impact on governance. It is suggested that different legal requirements be applied to the small-enterprise sector. Guidelines are proposed which legislators could use to assist the South African government in modifying the requirements of the LRA and the BCEA in respect of small enterprises. This study fills a gap in existing literature on small enterprises and governance in South Africa in the field of employment relations.
The Relationship between Employment Relationship, Employment Relations Satisfaction and Psychological Contracts in the South African Public Sector Workplace
Authors: Ntimba David Isaac , Lessing Karel Frederick , Swarts Ilze
Published: May 2023

The Global Competitiveness Report of 2014 rated the South African labour market as the lowest (137th position) out of the 137 countries measured with regard to employment relationship, which included cooperation in labour–employer relations. In the 2018 report, 148 countries were rated, and again South Africa was placed in the last position. The antagonism that continues to characterise employment relationship in the South African workplace in general and the public sector in particular has impacted equally negatively on employment relations satisfaction and the fulfilment of the psychological contract. This article explores the interrelationship between the three variables (employment relationship, employment relations satisfaction and psychological contract), and the effect that each has on workplace relations in general. The study adopted a quantitative research approach and used a survey design. A proportionate stratified random sampling method was used to determine the sample size, and the data were collected through a structured questionnaire. A scientific analysis of the data results revealed that psychological contract was a mediator and that employment relationship was a predictor that had a direct influence on both psychological contract and employment relations satisfaction. Based on the mediation results, the researchers reached the conclusion that employment relationship and employment relations satisfaction were both influenced by psychological contract. Therefore they recommend that, to improve relationships in the South African workplace, management and employees should invest more effort in encouraging a positive employment relationship and the fulfilment of psychological contract obligations.
Organisational Justice among Engineers at a South African Energy Provider: A Demographic Analysis
Authors: Schultz Cecile , Molopo Anna G. , Lessing Karel F.
Published: May 2023

Employees’ perceived fairness may greatly influence their employee relations, attitudes and behaviours. A demographic analysis to investigate the perceived fairness among engineers at a South African energy provider has not yet been conducted. Thus, the purpose of the current research study was to analyse the demographics of engineers at a South African energy provider in terms of organisational justice. A quantitative research method was used and 229 engineers – 164 engineers, 44 senior engineers and 21 chief engineers – participated in the study. The results showed that there were no significant relationships between the demographic variables and organisational justice. There were significant differences in how the different occupational levels perceived procedural justice, but no difference in how they perceived interpersonal justice. For the chief engineers, gender and occupational level significantly predicted organisational justice. A practical implication of the study is that the findings provided useful insight regarding the occupational level of chief engineer who perceived procedural justice in a positive light, while the occupational levels of chief engineer and engineer held a positive perception regarding organisational justice. The contribution of the study lies in the fact that all occupational levels of engineers should be treated in the same way and that demographic differences should be taken into consideration in doing so. It is recommended that management encourage a culture of employee interactions since this will improve interpersonal justice; ensure transparency regarding what is happening in the organisation; and eliminate uncertainty through employee engagement sessions.
Yetenek Yönetimi Uygulamalarının Çalışanların Kariyer Planlaması Üzerindeki Etkisi
Authors: ERAT Leyla , ÇELİK Adnan
Published: May 2023

Araştırmada, konaklama işletmelerinde çalışan kişilerin yetenek yönetimi uygulamalarına ilişkin algılarının, kariyer planlaması üzerindeki etkisinin incelenmesi hedeflenmiştir. Bu hedefe ulaşmak için Konya'da bulunan 4 ve 5 yıldızlı konaklama işletmelerinin çalışanları dâhil edilmiştir. Çalışmada, amaca göre örnekleme yöntemi kullanılmış olup, örneklem 140 çalışandan oluşmaktadır. Elde edilen veriler SPSS 21,0 programı ile analiz edilmiştir. Çalışmanın sonucunda; kuruma güven yetenek yönetimi uygulamasının kariyer planlamasının örgütsel kariyer planlaması boyutu üzerinde anlamlı etkisinin olduğu tespit edilmiştir. Yetenek yönetimi uygulamalarının kurum desteği ve operasyonel uyum boyutunun kariyer planlamasının örgütsel kariyer planlaması boyutu üzerinde anlamlı etkiye sahip olduğu belirlenirken, yetkinlik yetenek yönetimi uygulamasının ise bireysel kariyer planlaması boyutu üzerinde anlamlı etkisinin olduğu tespit edilmiştir. Ayrıca iş tatmini yetenek yönetimi uygulamasının kariyer planlamasının örgütsel kariyer planlaması boyutu üzerinde anlamlı etkiye sahip olduğu tespit edilmiştir. Sonuçlar dikkate alındığında, konaklama işletmesi çalışanlarının yetenek yönetimi uygulamalarının kariyer planlaması üzerinde kısmi etkisinin olduğu sonucuna ulaşılmıştır.
Apresentação
Authors: Arruda Júnior Gerson Francisco de
Published: May 2023

This is another issue of the magazine Ágora Filosóficafica. It is composed of nine articles, whose subjects concern issues that underlie and underpin ethical, political and humanist values. In the first article, entitled "Dialogue and dialogism", we find a particularly productive theoretical focus on discourse analysis, which seeks to demonstrate that, in the context of dialogic studies, everyday dialogue not only has a prominent position as a classic form of linguistic activity, but also plays the role of a matrix that generates fundamental analogies for conducting the analysis of discursive phenomena,  the formulation of theoretical propositions and the establishment of specific terminology...
O perspectivismo (ameríndio) não é um humanismo
Authors: Ramos de Souza Alisson
Published: May 2023

Amerindian perspectivism – a concept incused by Viveiros de Castro – translates the idea, common to some Amazonian peoples, that all non-human animals were once and/or still are human-animals; indeed, not only are animals “virtually” human, but also spirits, meteorological phenomena, trees and mountains, etc. Therefore, humanity is the common condition shared by all beings. In this sense, this paper aims to place this notion beyond the contours of humanism, insofar as Amerindian perspectivism intends to be a thought that breaks with the humanist metaphysical tradition. For this, we will use the philosophy of Gilles Deleuze as a theoretical instrument, an explicit reference to Viveiros de Castro.
Legalidade e legitimidade do processo legislativo no estado democrático: uma discussão sobre a esfera pública de Jürgen Habermas e a ordem simbólica de Nancy Fraser
Authors: Pepino Emanuel José Lopes , Leal Raniella
Published: May 2023

The present work aims to analyze whether legality can be considered a consequence of the legitimacy of the legislative process in the Democratic State. To answer this question, based on the hypothetical-deductive method, through a bibliographical review, this article is based on the deliberative policy proposed by Habermas, as a construction of the discursive dialogue of the citizens' opinion and will, based on a critical reflection of the contributions by Nancy Fraser on the symbolic order of systems of domination. Based on this investigation, the main result is that assuming a legitimate process that welcomes everyone equally is an ideal that has not yet been achieved.
Perfil epidemiológico dos pacientes com hanseníase em uma Unidade Básica de Saúde Maranhense
Authors: Silva João Victor de Araújo , Oliveira Neto Antônio Dorlival de , Silva Daniely Santos , Ferreira Gizele Cristine Serra Campos , Gomes Janildes Maria Silva , Lucena Bethânia Dias de
Published: May 2023

Objetivo: Identificar o perfil epidemiológico dos pacientes com hanseníase em uma Unidade Básica de Saúde Maranhense entre os anos de 2015 a 2020. Métodos: Trata-se de um estudo quantitativo epidemiológico, individual, observacional, transversal e descritivo. A população de estudo escolhida é composta de pessoas com diagnóstico de hanseníase acompanhadas em uma Unidade Básica de Saúde no período de 2015 a 2020. Resultados:  O número de casos de hanseníase foi de 23 pacientes diagnosticados e/ou tratados no período determinado. A partir disso, houve a caracterização dos pacientes, com dados referentes a média das idades, escolaridade, situação conjugal, renda, hábitos de vida, modo de entrada, forma clínica e classificação operacional predominantes nesta Unidade. Verificou-se, que a média de idades foi de 48,6 anos, os grupos eram bem distribuídos quanto a escolaridade e a hanseníase multibacilar e dimórfica foram as mais prevalentes na região. A alta por cura ocorreu em quase 100% dos casos analisados. Conclusão: A pesquisa demonstra que a população adulta foi a mais atingida, mas não exclusivamente. A escolaridade não foi um fator impeditivo para se adquirir a doença. A forma multibacilar foi mais prevalente. Há endemia de casos, com decréscimo de diagnósticos durante pandemia em 2020.
Predictability of osseointegrated implants installed in guided bone regeneration areas: a retrospective study
Authors: Pinheiro Marina Prado Fernandes , Quinelato Valquíria , Moreno Mylena Duim , Pinheiro Cintia Carneiro , Duarte João Gabriel Ribeiro , Mesquita Hariton de Souza , Casado Priscila Ladeira , Gonçalves Rackel , Aguiar Telma Regina da Silva , Machado Aldir Nascimento
Published: May 2023

Objective: To evaluate the predictability and success rate of implants installed in extraction sites, where the Guided Bone Regeneration (GBR) technique for bone preservation and implant placement was performed. Methods: This is a retrospective study, which included medical records of patients from the clinic of the Specialization in Implantology course from the educational institution, who underwent GBR in the tooth socket with indicated extraction, who delivered the tomographic exams, and had implants installed in these places, from 2007 to 2016. Forty-two participants were included in the research, totaling 55 sites divided into two groups: maxilla and mandible. Results: Two cases (3.7%) of non-bone formation were found after GBR, in the posterior region of the maxilla, with a success rate of 96.3% for predictability of implant placement in GBR sites. Of the 53 implants installed where there was sufficient bone formation, 3 (5.7%) did not return to the clinic and, therefore, 50 were evaluated, with 48 presenting clinical osseointegration with a success rate of 96%. Conclusion: There is predictability of GBR procedures in post-extraction sockets for the installation of osseointegrated implants.
Modelos animais para infecção experimental pelo vírus Zika: uma revisão sistemática
Authors: Bandeira Derick Mendes , Almeida Ana Luisa Teixeira de , Caldas Gabriela Cardoso , Barreto-Vieira Debora Ferreira
Published: May 2023

Objetivo: Investigar na literatura modelos animais utilizados para pesquisa com o vírus Zika em que haja a possibilidade de quantificação de carga viral e análises histopatológicas. Métodos: Trata-se de uma revisão sistemática redigida de acordo com as diretrizes do método PRISMA (2020). Os autores realizaram a busca inicial de artigos nas plataformas PubMed, Embase, Google Acadêmico, LILACS e Scielo. Resultados: Foram encontrados inicialmente 735 artigos, dos quais 27 foram incluídos após avaliação pelos critérios de inclusão e exclusão. Camundongos e primatas não-humanos foram as espécies mais utilizadas (88,89% dos estudos). A cepa viral mais frequente foi a PRVABC59 (Porto Rico, 2015) e, em 77,78% dos estudos, o vírus foi inoculado por via subcutânea. Entre os sinais clínicos mais reportados estão a conjuntivite/secreção ocular, paralisia dos membros inferiores, letargia e postura arqueada. As análises histopatológicas foram feitas principalmente em cérebro e presença de infiltrado inflamatório e degeneração celular foram as alterações mais comuns. Considerações finais: Todos os modelos animais analisados apresentaram manifestações clínicas relevantes da infecção pelo vírus Zika. No entanto, a maior parte dos estudos investiga danos cerebrais, não caracterizando os danos histopatológicos em outros órgãos. Além disso, considerando a ampla biodiversidade de espécies, novos modelos animais podem ser investigados.
“Ping-pong” fracture: An exclusive entity of neonates and infants? A case analysis and literature review
Authors: Minghinelli Federico E. , Marquez Yamila Basilotta , Pipolo Derek Orlando , Recalde Rodolfo José , Mantese Beatriz , Rugilo Carlos
Published: May 2023

Background:

“Ping-pong” fractures are a type of depressed fracture in which there is no rupture of the inner or outer table of the skull. It is produced by incomplete bone mineralization. Its appearance is frequent during neonatal and infant ages and is extremely rare outside of these age periods. The objective of this article is to present the case of a 16-year-old patient who presented a “ping-pong” fracture after a traumatic brain injury (TBI) and discuss the underlying physiopathogenesis of these types of fractures.

Case Description:

A 16-year-old patient presented to the emergency department with a TBI, referring headaches and nausea. Non-contrast brain computed tomography displayed a left parietal “ping-pong” fracture. Laboratory tests showed hypocalcemia, subsequently diagnosing hypoparathyroidism. The patient remained under observation for 48 h. He was managed conservatively and started on calcium carbonate and vitamin D supplements with a favorable evolution. Hospital discharge was granted with TBI discharge instructions and warning signs.

Conclusion:

The age of presentation of our case was atypical, according to the reported literature. When faced with a “ping-pong” fracture outside of an early age, underlying bone pathologies must be ruled out, which could potentially generate incomplete bone mineralization of the skull.
Supraorbital keyhole approach for paraclinoid aneurysms clipping: A case series with literature review
Authors: Abdulateef Awfa Aktham , Morita Shuhei , Ismail Mustafa , Sharma Mayur , Hoz Samer S. , Numazawa Shinichi , Ito Yasunobu , Watanabe Sadayoshi , Mori Kentaro
Published: May 2023

Background:

Paraclinoid aneurysms (PcAs) are challenging aneurysms due to the complexity of their relation to the surrounding bony and neurovascular structures. Although over the past decade, their management strategy has shifted from transcranial to endovascular approaches; here, we try to revolve around a subcategory to which minimal invasive supraorbital keyhole (SOK) surgery is feasible depending on specific radiological criteria with a literature review.

Methods:

A group of unruptured PcAs was managed surgically, with a subset that was clipped through the SOK approach. They were selected by preoperative simulation images using 3D computed tomography (CT) angiography (CTA). We also conducted an extensive literature review based on a database available on PubMed and Google Scholar, the yielded cases from the literature review plus our cases were analyzed according to six parameters including their size, location, dome direction, need for clinoidectomy and proximal cervical control, and surgical outcome.

Results:

From February 2009 to August 2022, 49 cases of unruptured PcAs were managed by clipping, and of these, four cases were clipped by the SOK approach, in addition, four cases were yielded through the literature review. The sizes of the PcAs ranged from 3 to 8 mm. Their location fluctuated from anterior to the superomedial wall and their domes pointed superiorly except for one which points posteriorly. Six of eight cases required anterior clinoidectomy, the outcome was uneventful.

Conclusion:

A subset of unruptured PcAs are amenable to SOK with criteria such as unruptured small aneurysm (<10 mm) and projected superiorly. These characteristics can be determined preoperatively using CTA.
Une image ne démontre pas, elle convainc
Authors: Edeline Francis
Published: May 2023

La démarche scientifique consiste, dans un premier temps, à décrire correctement le monde réel. Dans un second temps elle cherche à fournir de cette description un équivalent symbolique, appelé modèle, dont le fonctionnement soit capable de reproduire, aussi fidèlement que possible, les caractéristiques spatiales et temporelles du monde réel. Dans l’ensemble de ces opérations le scientifique fait presque toujours appel à la visualisation, quoique ce ne soit pas strictement indispensable, et fasse même courir le risque de tomber dans divers pièges. Si l’image reste néanmoins universellement utilisée, c’est qu’elle présente par ailleurs des avantages, au premier rang desquels la possibilité d’embrasser d’un seul coup d’œil l’ensemble d’un phénomène ou d’un processus. C’est sur une image qu’on perçoit le mieux la correspondance entre un modèle et des points expérimentaux, et c’est donc d’ordinaire l’image qui conditionne le degré de conviction du chercheur.Néanmoins seuls le langage logique et le langage mathématique ont valeur démonstrative. Il suffit d’ébaucher une théorie de la mesure pour s’apercevoir que la transposition du domaine des nombres à celui des images ne peut être qu’approximative. On soulèvera également le problème épistémologique du statut exact du concept de modèle, c’est-à-dire de la possibilité même de faire correspondre une équation au monde réel. Il apparaîtra qu’une modélisation est toujours un compromis entre deux excès : l’excès de généralité et la surparamé-trisation.
Le statut sémiotique de l’image. Rapport d’expérience sur l’intersémiotique dans le discours scientifique (second volet)
Authors: Badir Sémir
Published: May 2023

Dans Visible 5, j’ai présenté une étude où un schéma extrait d’une revue de vulgarisation scientifique a été mis en regard de ses paraphrases verbales, obtenues par questionnaire dans un milieu scolaire. Je propose aujourd’hui le chemin inverse, soit la confrontation d’un énoncé verbal (qui aurait convenu comme paraphrase du schéma initial) avec ses représentations visuelles, obtenues suivant un procédé identique à celui de la première étude. Les questions qui sont soulevées à l’occasion de cet exercice de transcodage concernent la capacité d’analyse des images, les spécificités de leur visée métalinguistique, ainsi que leur fonction dans une argumentation de type scientifique.
L’iconographie du volcan à la croisée des disciplines : représentations savantes et vues pittoresques dans la Dation Krafft
Authors: BÉLANGER Bettina
Published: May 2023

L’imagerie volcanique se déploie principalement dès la seconde moitié du XVIIIe en corrélation avec les découvertes scientifiques de la période. Naples et le Vésuve sont au cœur de cette nouvelle thématique chère aux artistes et voyageurs du Grand Tour. William Hamilton en Italie et Alexander von Humboldt en Amérique du Sud étudieront les volcans les plus emblématiques et diffuseront les connaissances acquises par le biais d’ouvrages abondamment illustrés.
Évolution du statut de la carte au sein des publications scientifiques
Authors: Birchenall Claire
Published: May 2023

Dès 1864, la carte fait partie intégrante des articles publiés dans la revue Médecine tropicale. C’est à l’origine un élément d’illustration qui devient peu à peu un outil essentiel de recherche et de communication des résultats scientifiques. L’analyse des cartes publiées de 1864 à 1964 dans la revue Médecine Tropicale reflète l’évolution de l’utilisation de ce support d’information par les auteurs.
Blessed Basils Fourmode-Chant “Vostrubim Truboyu Pesney” in the Sacred Space of Moscow Cathedrals of the Late 16th — Early 17th Centuries
Authors: Мицкевич М.С. , Швец Т.В.
Published: May 2023

Статья посвящена исследованию и публикации четверогласника из службы Василию Блаженному. Четверогласник — песнопение, разделенное на четыре части, каждая из которых роспета в одном из гласов. Известны несколько песнопений-четверогласников с инципитом «Вострубим трубою песней». Их основной репертуар был выявлен на материале Стихираря «Дьячье Око» из собрания Д. В. Разумовского. Все песнопения выписаны в чинопоследованиях святителям, за исключением службы юродивому Василию Блаженному. Анализ характерных особенностей строения музыкальной формы четверогласников «Вострубим трубою песней» показал, что песнопения строятся по одной модели, определяемой как общая художественная модель «святительских» четверогласников. В поэтическом тексте стихиры Василию Блаженному выделяются: мотив сакрального пространства Москвы, мотив мощей; центральной становится молитва о чадородии для царской четы Федора Иоанновича и царицы Ирины, подчеркнутая музыкальными средствами. В статье впервые публикуется четверогласник Василию Блаженному «Вострубим трубою песней» с расшифровкой.

The article is devoted to the research and analysis of the fourmode-chant in the Blessed Basil church service. The Fourmode-chant – is a chant divided into four parts, each of which is chanted in one of the modes. In ancient Russian hymnography several fourmode-chant with incipit “Vostrubim truboyu pesney” (“Let us sound the trumpet of festal hymns”) are known. The main repertoire of which was revealed and analysed on the material of Sticherarion “D’yachye Oko” from D. V. Razumovsky’s collection of manuscripts. Frequently fourmode-chants with this incipit appear in services dedicated to church hierarchs. The chants are composed according to one common model called artistic model of  “hierarchal” fourmode-chants. Each mode has a semantic meaning in the poetic composition of the heteromode-chant. The musical and poetic structure of chants contains common and independent fragments that distinguish the degree of independence of the pieces. The hymn of St. Basil reflects the meaning and nature of the worship of the saint. The poetic text of the sticheron highlights the sacred space of Moscow, in the center of which a sacred rite takes place, the motive of relics and a prayer for childbearing for the royal couple of Feodor I Ioannovich and Irina Feodorovna. This prayer is emphasized by musical media. This prayer is the central motive of the whole text. The article presents for the first time a transcription of the chant “Vostrubim truboyu pesney” from Blessed Basil’s service.
Beyond Metal-Arenes: Monocarbonyl Ruthenium(II) Catalysts for Transfer Hydrogenation Reactions in Cancer Cells
Authors: Lovison Denise , Berghausen Tobias , Thomas Sophie , Robson Jonathan , Drees Markus , Jandl Christian , Mollik Patrick , Halter Dominik , Baratta Walter , Casini Angela
Published: May 2023

With the aim to design new water-soluble organometallic Ru(II) complexes acting as anticancer agents catalysing transfer hydrogenation (TH) reactions with biomolecules, we have synthesized four Ru(II) monocarbonyl complexes (1-4) featuring the 1,4-bis(diphenylphosphino)butane (dppb) ligand and different bidentate nitrogen (N^N) ligands, of general formula [Ru(OAc)CO(dppb)(N^N)]n (n = +1, 0; OAc = acetate). The compounds have been characterised by different methods, including 1H and 31P NMR spectroscopy, electrochemistry as well as single crystals X-ray diffraction in the case of 1 and 4. The compounds have also been studied for their hydrolysis in aqueous environment, and for the catalytic regioselective reduction of NAD+ to 1,4-NADH in aqueous solution with sodium formate as hydride source. Moreover, the stoichiometric and catalytic oxidation of 1,4-NADH have also been investigated by UV-Visible spectrophotometry and NMR spectroscopy. Overall, initial structure-activity relationships could be inferred which point towards the influence of the extension of the aromatic N^N ligand in the cationic complexes 1-3 on the TH in both reduction/oxidation processes. The neutral complex 4, featuring a picolinamidate N^N ligand, stands out as the most active catalyst for the reduction of NAD+, while being completely inactive towards NADH oxidation. The compound can also convert pyruvate into lactate in the presence of formate, albeit with scarce efficiency. In any case, for all compounds, Ru(II) hydride intermediates could be observed and even isolated in the case of complexes 1-3. Together, insight from the kinetic and electrochemical characterization suggests that, in the case of Ru(II) complexes 1-3, catalytic NADH oxidation sees the H-transfer from 1,4-NADH as the rate limiting step, whereas for NAD+ hydrogenation with formate as the H-donor, the rate limiting step is the transfer of the ruthenium hydride to the NAD+ substrate. The latter is further modulated by the presence of di-cationic aquo- or mono-cationic hydroxo-species of complexes 1-3. Instead, compound 4, stable with respect to hydrolysis in aqueous solution, appears to operate via a different mechanism. Finally, the anticancer activity and ability to form reactive oxygen species (ROS) of complexes 1-3 have been studied in cancerous and non-tumorigenic cells in vitro. Noteworthy, the conversion of aldehydes to alcohols could be achieved by the three Ru(II) catalysts in living cells, as assessed by fluorescence microscopy. Furthermore, the formation of Ru(II) hydride intermediate upon treatment of cancer cell extracts with complex 3 has been detected by 1H NMR spectroscopy. Overall, this study paves the way to the application of non-arene based organometallic complexes as TH catalysts in biological environment.
Monolithic two-terminal tandem solar cells using Sb2S3 and solution-processed PbS quantum dots achieving an open-circuit potential beyond 1.1 V
Authors: Kern Selina , Yi Gyusang , Büttner Pascal , Scheler Florian , Tran Minh-Hoa , Korenko Sofia , Dehm Katharina E. , Kundrata Ivan , Albrecht Steve , Bachmann Julien , Crisp Ryan W.
Published: May 2023

Multijunction solar cells show the prospect to raise the theoretical efficiency limit of single junction solar cells by minimizing transmissive losses of large bandgap and emissive losses of lower bandgap absorber solar cells. In solar cell applications, Sb2S3 is considered an attractive absorber due to its elemental abundance, stability, and high absorption coefficient in the visible range of the solar spectrum, yet with a band gap of 1.7 eV it is transmissive for near-IR and IR photons. Using it as the top cell inside a tandem solar architecture in combination with a bottom cell employing e.g., PbS quantum dots, which have an adjustable band gap suitable for absorbing longer wavelengths, is hence a promising approach to harvest the solar spectrum more effectively. In this work, these two subcells are monolithically grown and connected in series by a poly(3,4-ethylene-dioxythiophene) polystyrene sulfonate (PEDOT:PSS)−ZnO tunnel junction as the recombination layer. We explore the surface morphology of ZnO QDs resulting from different spin coating conditions, which serve as the bottom cell’s electron transport material. Furthermore, we examine the differences in photogenerated current upon varying the PbS QDs absorber layer thickness and the electrical and optical characteristics of the tandem with respect to the standalone reference cells. This tandem architecture demonstrates an extended spectral absorption into the IR with an open-circuit potential exceeding 1.1 V and a power conversion efficiency of 5.6%, projecting above the PCE of each single-junction cell.
In-Silico Approach for Identification of The Most Potent JAK Inhibitors as a Possible Treatment for Myelofibrosis
Authors: Santoso Natasya Irene , Mᴀʀɪɴɢᴋᴀ Stephanie Grace , Nadya Kelly , Yeo Celine , Budiono Ellen , Catherine Aurelia , Kristi Danita Sherry , parikesit arli aditya
Published: May 2023

Background: Myelofibrosis is a type of malignancy that is mainly caused by JAK2 gene mutation. This study employed an in silico approach to analyse the binding affinity of five JAK2 inhibitors that were already FDA-approved in order to determine the most effective JAK2 inhibitor to suppress the overstimulating JAK-STATs caused by the mutation Methods: The 3D structure of JAK2 protein was built using the Swiss-Prot Expas and loaded into PyMol to remove the solvent and add the hydrogen atom. On the other hand, five JAK inhibitors including Ruxolitinib, Fedratinib, Momelotinib, Pacritinib, and Ilginatinib (NS-018) were retrieved in 3D conformer from the PubChem NCBI database. The ligands were minimized and combined with the JAK2 protein using PyRx, as well as to be visualized using BIOVE and Castp. Results: The molecular docking analysis showed that Fedratinib has the most negative binding affinity followed by Pacritinib, Ruxolitinib, Ilginitinib, and Momelotinib. By comparing BIOVIA and Castp visualisation results, all JAK2 inhibitors bind to the JAK2 protein Pocket 1 Chain A, whereas Ruxolitinib and Momelotinib have an additional binding to JAK2 protein Pocket 1 Chain B. Conclusion: Fedratinib is the most potent JAK2 inhibitor based on the binding affinity it possesses. Further pharmacology research is required to analyse further the efficacy and safety of the Fedratinib.
Microscopic Origin of Electrochemical Capacitance in Metal-Organic Frameworks
Authors: Shin Seung-Jae , Walsh Aron , Gittins Jamie W. , Golomb Matthias J. , Forse Alexander C.
Published: May 2023

Electroconductive metal-organic frameworks (MOFs) have emerged as high-performance electrode materials for supercapacitors, but the fundamental understanding of the underlying chemical processes is limited. Here, the electrochemical interface of Cu3(HHTP)2 (HHTP=2,3,6,7,10,11-hexahydroxytriphenylene) with an organic electrolyte is investigated using a multi-scale quantum-mechanics/molecular-mechanics (QM/MM) procedure and experimental electrochemistry measurements. Our simulations reproduce the observed capacitance values and reveals the polarisation phenomena of the nanoporous framework. We find that excess charges mainly form on the organic ligand and cation-dominated charging mechanisms give rise to greater capacitance. The spatially confined electric double-layer structure is further manipulated by changing the ligand from HHTP to HITP (HITP=2,3,6,7,10,11-hexaiminotriphenylene). This minimal change to the electrode framework not only increases the capacitance but also increases the diffusion coefficients of in-pore electrolytes. The performance of MOF-based supercapacitors can be systematically controlled by modifying the ligating group.