bluuebunny/crossref_metadata_2025 huggingface dataset:
Psychological status of mothers of children with cystic fibrosis and primary ciliary dyskinesia
Authors: Gursoy Tugba Ramasli , Eyuboglu Tugba Sismanlar , Aslan Ayse , Emiralioğlu Nagehan , Pekcan Sevgi , Buyukkaya Eda , Hangul Melih , KOSE MEHMET , Soysal Sebnem , Budakoğlu Işıl
Published: December 2021

Objectives: We aimed to investigate depression, burnout, attitude, and
burden of caregivers of children with cystic fibrosis (CF), and
especially caregivers of children with primary ciliary dyskinesia (PCD)
due to limited number of studies on this topic, and to compare them
according to their children’s clinical status. Methods: Clinical
features and demographic data of children and their families were asked
to caregivers in four pediatric pulmonology centers. Beck Depression
Inventory (BDI), Maslach Burnout Inventory (MBI), Zarit Caregiver Burden
Scale (ZCBS), and Parental Attitude Research Instrument (PARI) were
administered to caregivers in both groups. Results were compared between
the two groups. Results: In total, 131 children with CF and 39 with PCD
and their caregivers were involved in study. All primary caregivers were
mothers in both groups. Depression, burnout, and burden scores of
mothers of children with CF were significantly higher than mothers of
children with PCD (p=0.017, p=0.024, p=0.038, respectively). Burnout was
higher in both CF and PCD groups with low family income (p=0.022,
p=0.034). Number of hospital visits in the previous six months was
correlated with burnout in both CF and PCD groups (r=0.207, p=0.034;
r=0.352, p=0.044). Conclusions: Although mothers of children with CF
have higher depression, burnout, burden, and negative attitudes towards
children than mothers of children with PCD, it is disregarded in mothers
of children with PCD. Psychological problems of mothers of children with
CF and PCD may increase with frequent hospital visits, hospitalizations,
low family income, number of children, and chronic disease in another
child.
Primary solitary fibrous tumor of the thyroid gland: A review starting from a case report
Authors:   Pathology Department, “Sf. Spiridon” Emergency County Clinical Hospital, Iasi, Romania, Negură Ion , Ianole Victor ,   Pathology Department, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Dănilă Radu ,   Department of Surgery, III-rd Surgical Unit, “Sf. Spiridon” Emergency County Clinical Hospital, “Grigore T. Popa” University of Medicine and Pharmacy, Iasi, Romania
Published: December 2021

Primary solitary fibrous tumor (SFT) of the thyroid gland is a rare mesenchymal tumor with fibroblastic differentiation, ramified, thin-walled, enlarged (staghorn) vessels and specific NAB2-STAT6 gene fusion, which is more commonly found in pleura and peritoneum. This neoplasm can be located in a variety of anatomical sites outside pleura and peritoneum including bone, visceral organs and soft tissues, head and neck examples representing only 10-15% of the extra-pleural and extra-peritoneal tumors. Diagnosing this entity can be difficult, especially in thyroid gland, mainly because of the rarity of this neoplasm, but presence of characteristic microscopic features together with positivity for STAT6 and CD34 can confirm the diagnosis and exclude other differential diagnosis. Information about the diagnosis and treatment options of thyroid SFTs is limited but almost all primary thyroid SFTs have a good prognosis and indolent clinical course. Clinical surveillance is still necessary because some SFTs can be aggressive. Raising awareness regarding extra-pleural and extra-peritoneal location of this tumor in endocrine organs can help to better manage these patients. We report the case of a 34-year-old female with primary SFT of the thyroid gland. Additionally, we review the literature for the main clinical, paraclinical and pathological features of this neoplasm.
THE MULTIPLE REGRESSION MODEL WITH DICHOTOMOUS VARIABLES IN ANALYSIS OF MULTI-SECTIONAL DEMAND FOR CONNECTIVITY SERVICES – APPROACH BASED ON PER SECOND BILLING
Authors: Kaczmarczyk Paweł
Published: December 2021

The article presents the results of comparative research of the effectiveness of two types of models in terms of approximation and short-term forecasting of the multi-sectional demand for connectivity services. The presented results of the analyses are related to the selection of an appropriate forecasting method as an element of the Prediction System dedicated to telecommunications operators. The first tested model was a multiple regression model with dichotomous explanatory variables. The second model was a multiple regression model with dichotomous explanatory variables and autoregression. In both models, the dependent variable was the hourly counted seconds of outgoing calls within the network of the selected operator. Telephone calls were analysed in terms of such classification factors as: type of day, category of call, group of subscribers. Taking into account all levels of classification factors of the explanatory variable, 35 dichotomous explanatory variables were specified. The defined set of dichotomous explanatory variables was used in the estimation process of both compared regression models. However, in the second model, first-order autoregression was additionally applied. The second model (multiple regression model with dichotomous explanatory variables with first-order autoregression) was found to have higher approximation and predictive capabilities than the first model (multiple regression model with dichotomous explanatory variables without autoregression).
GRAPHICAL APPROACH TO AGE-PERIOD-COHORT ANALYSIS
Authors: Sagan Adam
Published: December 2021

The paper presents the graphical approach to decomposition of APC effect in cohort studies (mainly applied to demographic phenomena) using multilevel or accelerated longitudinal design. The aim of the paper is to present and visualize the pure age, period and cohort effects based on simulated data with an increment of five for each successive age, period and cohort variation. In cohort analysis on real data all of the effects are usually interrelated. The analysis shows basic patterns of two-variate APC decomposition (age within period, age within cohort, cohort within period, period within age, cohort within age, period within cohort) and reveals the trajectory of curves for each of the pure effects. The APC plots are developed using apc library of R package.
The importance of Pierre Bourdieu today. On consent to misery
Authors: Crépon Marc
Published: December 2021

This article reflects on the crisis of political reason in this heyday of
populistic rhetoric, proposing to move beyond the erroneous dichotomy
between ?democratic reason? and ?raging passions,? and the demo-phobia that
often derives from it. We propose instead to follow Bourdieu?s footsteps in
bringing our attention to the forms of impermeability that fracture our
contemporary political and social life, establishing the conditions of
possibility of the reasonable and the unreasonable. What marks contemporary
political passions as particularly dangerous is their impermeability to the
lessons of our historical past, to the moral condemnation of the political
instrumentalization of difference and to the sacred character of fundamental
principles. This hermeneutical gap, however, is later explained by a more
fundamental analysis of the problem of contemporary impermeability, one
which operates as a reversal of the dichotomy between political reason and
passion. It is no longer the electorate, seduced by the sirens of populism,
which is impermeable to the voice of political reason; it is, instead, this
very reason, embodied by the elites who claim to recognize themselves in its
values and principles, which has become impermeable to the ?conditions of
non-existence? in which a considerable part of the population lives. If
there is a problem of contemporary impermeability, or imperturbability, it
is that of a political discourse that has lost touch with ?all the misery of
the world?.
Bourdieu’s theorization of social capital in the analysis of South-East European societies
Authors: Petric Mirko , Tomic-Koludrovic Inga
Published: December 2021

This article discusses the significance of social capital in
Bourdieu-inspired analyses of contemporary South-East European societies. We
first recapitulate Bourdieu?s theorization of social capital, emphasizing
that it allows different operationalizations expressly because of its rather
abstract theoretical character. Following that, we explain what is meant by
?South- East European societies? and that their inequality-generating
mechanisms are largely based on social closure. In the central part of the
article, we comment on some attempts at operationalization of social capital
in the SEE region. While we also discuss two cases of eclectically mixing
Lin?s operationalization with Bourdieusian concepts, at the center of our
attention is the elaboration of Bourdieu?s theorization of social capital
put forward by the Serbian sociologist Predrag Cveticanin. The relevance of
his concepts of ?social capital of solidarity? and ?social capital of
informal connections? for the study of class relations in post-socialist
societies in South-East Europe highlights the advantages of a consistent
application of the Bourdieusian framework in a contemporary
(post-Bourdieusian) context.
Pierre Bourdieu and politics
Authors: Golub Philip , Lebaron Frédéric , Mladenovic Ivica , Poupeau Franck , Sapiro Gisèle , Zaric Zona
Published: December 2021

This paper is the product of a roundtable discussion held at the
international conference Horizons of Engagement: Eternalizing Bourdieu,
organized by the Institute for Philosophy and Social Theory of Belgrade,
Serbia, the Centre for Advanced Studies of The University of Rijeka,
Croatia, the ?cole Normale Sup?rieure of Paris, France, and the French
Institute in Serbia. The event was planned on the occasion of the ninetieth
anniversary of the birth of one of the world?s leading sociologists - Pierre
Bourdieu (1930-2002). The greatest indicator of the scope of Bourdieu?s
influence is the fact that he has become the world?s most cited sociologist,
ahead of ?mile Durkheim, and the world?s second most cited author in social
sciences and the humanities, after Michel Foucault and ahead of Jacques
Derrida. As part of this discussion, we address the subject of ?Bourdieu and
Politics?, politics - broadly constructed. We evoke Pierre Bourdieu?s
involvement in public affairs during the 1990s, while taking into account
the concept of the collective intellectual that Bourdieu introduced into
social sciences by giving it a specific meaning.
The messiness of victory and heroism: A brief response to Carl Schmitt
Authors: Bojanic Petar , Djordjevic Edward
Published: December 2021

The article focuses on a passage from Carl Schmitt?s Ex Captivitate Salus - a
book famously written in a Nurnberg prison in 1946 - in which he draws, from
memory, on a story derived from Serbian epic poetry, to justify his
understanding of historiography, victory, and the figure of the hero.
Analyzing the entire Serbian epic poem from which Schmitt extracts the
vignette in question, we show how the text of the poem presents a
significantly more complicated and messy picture of the figures of victor,
victory, and hero, heroism. The anonymous Serbian poet, addressing himself
to his contemporary audience, with which he is intimately familiar, really
subverts simplistic expectations regarding the heroism and victory of the
Serbian hero, Marko Kraljevic. Finally, the article contrasts these complex
and at times paradoxical figures of victory and the hero in the poem with
their presentation in Carl Schmitt?s writing.
Consent or public reason? Legitimacy of norms applied in ASPD and COVID-19 situations
Authors: Baccarini Elvio
Published: December 2021

This paper extends Alan John Simmons?s conceptual distinction between Lockean
(or consent) and Kantian (or justificatory) conceptions of legitimacy that
he applied to the question of the legitimacy of states, to the issue of
legitimacy of public decisions. I criticise the consent conception of
legitimacy defended by Simmons, and I defend the Rawlsian version of the
justificatory conception of legitimacy from his objection. The approach of
this paper is distinctive because the two conceptions are assessed by
investigating, using the method of reflective equilibrium, their respective
prescriptions concerning the treatment of antisocial personality disorder
(ASPD) and epidemiologic measures. I argue that the method of reflective
equilibrium does not support the consent conception. Considering the issues
of treatment of APD and of epidemiologic measures, I argue that the consent
conception of legitimacy is not well-equipped for the evaluation of norms
that are not strictly self-regarding. This causes a deficit of prescriptions
for relevant social responses. Further, by considering the case of responses
to epidemics, I argue that such a conception can avoid harmful consequences
only by recurring to additional, and independent, premises. This does not
cause incoherence but reduces the coherence of a normative system. Finally,
the consent conception is not equipped to support social cooperation in an
optimal way, which has proved to be necessary in critical conditions, like a
pandemic. On the other hand, I argue that the method of reflective
equilibrium supports the Rawlsian version of justificatory conception of
legitimacy, because of its advantages in handling the indicated issues. In
addition, I maintain that this justificatory conception is respectful of
freedom and equality of agents as moral self-legislators, and, thus, it is
not vulnerable to Simmons?s main criticism.
Hermeneutics of recollection: Gadamer and ricoeur
Authors: Ostojic Aleksandar
Published: December 2021

This paper analyzes the notion of recollection in Hans Georg Gadamer and Paul
Ricoeur?s thought, in the context of time distance as ?obstacles? towards
understanding the past. Particular attention is paid to the understanding
the phenomenon of ?Death? as a time gap between the past and the present. In
connection with this problem, we find efforts of philosophical hermeneutics
on the one hand and historicism on the other. Differences between
historicism and hermeneutics can be outlined in relation to the role that
memory plays in the process of understanding in Gadamer and Ricoeur. What
does Death mean in terms of understanding for history, and what for
hermeneutics? How can we understand temporal distance? Is it possible and
necessary to overcome it? What is the role of recollection and how does it
participate in understanding? - these are some of the main issues that will
be addressed in the text. Finally, the task of the text is to offer the
meaning and significance of the hermeneutics of recollection in relation to
the mentioned questions, through the interaction of the thoughts of the two
authors.
Now is the “We-Time.” Heidegger’s ‘Black Notebooks’ read as self-critical reflection of Nazi involvement
Authors: Jovanov Rastko
Published: December 2021

The article analyzes Heidegger?s relation to National Socialism based on his
private writing in the ?Black Notebooks,? published in their entirety (nine
volumes) this year. Although it is indisputable that Heidegger was an
enthusiastic adherent of the National Socialist program between 1930 and
1934, his private writings show his avowed philosophical delusion that the
National Socialist ?revolution? in Germany was going to bring about a new
beginning of philosophy beyond the metaphysical tradition. The article shows
how Heidegger criticized National Socialism after 1934, and the
circumstances of his resignation from the post of Rector of Freiburg
University in that year.
The entry and super-entry in a dictionary of idioms
Authors: Tafra Branka
Published: December 2021

This discussion of the entry and super-entry is the one that concerns both
the internal and external boundaries of the idiom and the identity of the
idiom and its components. It gives rise to three groups of issues. The first group includes the theoretical solutions that have already been
implemented in Croatian idiomatic lexicography, which constitute a significant shift in comparison to the previous state of linguistic knowledge. The
greatest shift undoubtedly lies in the demarcation between polysemy and
conversion and in the introduction of a multiword expression as a
super-entry. The second group involves proposing the strategies that can be
applied in idiomatic dictionaries, such as drawing a clearer distinction
between idiom variation and synonymy and identifying the occurrences of
onymization and deonymization of components. The third group of issues
uncover the dilemmas that seek solutions. First and foremost, what needs to
be resolved is the question of the nature of semi-compound words. If they
are to be treated as lexemes, which some of them are, then they cannot be
categorized as idioms, and if they are to be treated as phrases that can
turn into idioms, then they cannot be categorized as semi-compound words,
since the latter represents a term from the area of word-formation.
A linguistic investigation of disyllabic or feminine rhymes in Serbian poetry
Authors: Zec Draga
Published: December 2021

This paper focuses on the prosodic properties of disyllabic, that is to say,
feminine rhymes in Serbian poetry. On the basis of a quantitatively analyzed
poetic database, which includes eight poets, four from the Romantic and four
from the Post-Romantic period, we have identified word stress as a highly
relevant prosodic property. The investigation of its role in creating
rhyming pairs resulted in a classification of feminine rhymes into three
types: resonant, semi-resonant, and non-resonant. This classification is
based on the presence or absence of stress in the domain of rhyme, which
begins with the rightmost strong metrical position in a line, followed by a
weak final syllable. In resonant rhymes both lines that form a rhyming pair
contain stress in their domains, in semi-resonant rhymes only one of the
lines contains stress, while in non-resonant rhymes, stress is absent from
both. The role of stress is demarcative: it signals the beginning of the
domain of rhyme, thereby considerably promoting its effectiveness. The most
effective are resonant rhymes, with demarcated domains in both lines, next
in effectiveness are semi-resonant rhymes, with demarcation in only one of
the lines, while non-resonant rhymes, which lack demarcation, are the least
effective. Based on this classification, clear differences can be
established not only among individual poets, but also among poetic eras.
Moreover, the classification of feminine rhymes into resonant,
semi-resonant and non-resonant allows for a detailed insight into their
lexical composition, that is, into the prosodic profiles of words that
constitute them.
Influence of Control Precision and Prior Collaboration Experience on Trust and Cooperation in Inter-Organizational Relationships
Authors: Anderson Shannon W. , Cheng Mandy M. , Phua Yee Shih
Published: December 2021

We investigate whether prior collaboration experience affects a focal partner's response to the precision of monitoring controls adopted by a new partner, with consequences for their goodwill trust in, and subsequent cooperation with, the new partner. We expect the partner to interpret their new partner's adoption of precise monitoring controls as either an effort to limit their autonomy or to reduce information asymmetry. The partner's experience with past partners is posited to determine which interpretation is salient, with negative (positive) experiences favoring the former (latter). We find that partners with an uncooperative (cooperative) experience exhibit lower (higher) goodwill trust in the new partner when controls are more precise. Further, prior experience moderates the indirect relation between the precision of monitoring controls and partner cooperation acting through goodwill trust. The results demonstrate the importance of prior experiences in the design of interfirm controls for current partner relationships.

Data Availability: Contact the authors.

JEL Classifications: M41.
Use and Usability Of Custom-Made Knee-Ankle-Foot Orthoses In Polio Survivors with Knee Instability: A Cross-Sectional Survey
Authors: Raijmakers Bart , Berendsen-de Gooijer Roelofine A. , Ploeger Hilde E. , Koopman Fieke S. , Nollet Frans , Brehm Merel-Anne
Published: December 2021

Objective: To investigate the use of custom-made knee-ankle-foot orthoses in daily life and differences in usability factors of knee-ankle-foot orthoses between users and discontinued users.Design: Cross-sectional survey study.Subjects: A total of 163 polio survivors provided with a knee-ankle-foot orthosis at an outpatient clinic of a university hospital.Methods: Use and usability of knee-ankle-foot orthoses in daily life were assessed with a postal questionnaire. Usability factors were formulated using the International Organization for Standardization (ISO) 9241-11 standard.Results: A total of 106 respondents (65%) returned the questionnaire. Of these, 98 were eligible for analysis. Seventy-four respondents (76%) reported using their knee-ankle-foot orthosis. Compared with discontinued users (24%), users experienced more limitations when walking without an orthosis (p = 0.001), were more often experienced with wearing a previous orthosis (p < 0.001) and were more often prescribed with a locked rather than a stance-control knee-ankle-foot orthosis (p = 0.015). Furthermore, users reported better effectiveness of their knee-ankle-foot orthosis (p < 0.001), more satisfaction with goals of use and knee-ankle-foot orthosis-related aspects (p < 0.001).Conclusion: The majority of polio survivors used their custom-made knee-ankle-foot orthoses in daily life. Factors related to continued use, such as walking ability without orthosis, expectations of the orthosis, previous orthosis experience and type of knee-ankle-foot orthosis provided, should be considered and discussed when prescribing a knee-ankle-foot orthosis in polio survivors.
LAY ABSTRACTKnee-ankle-foot orthoses for knee instability are commonly prescribed in polio survivors to enhance safe ambulation. This survey investigated the use of knee-ankle-foot orthoses in daily life and differences in factors of usability between users and discontinued users. Seventy-six percent of polio survivors used their custom-made knee-ankle-foot orthosis in daily life. Important usability factors that were related to continued use of knee-ankle-foot orthoses were low perceived walking ability status without orthosis, previous orthosis experience, high perceived effectiveness and satisfaction when standing and walking with a knee-ankle-foot orthoses. When prescribing a custom-made knee-ankle-foot orthoses it is important to consider these factors and discuss goals of use and expected benefits of the knee-ankle-foot orthoses with the patient, especially in relation to perceived walking limitations and activities in daily life.
The development and evaluation of a web-based well-being intervention, for inclusion within an existing health promotion programme, to support and encourage health related lifestyle behaviour change
Authors:   , Brown Menna
Published: December 2021

Unhealthy lifestyle behaviours constitute a significant burden of disease, globally. Web-based interventions offer a means to support individuals in adopting and maintaining positive healthy lifestyle behaviours to address and reduce this issue. The health behaviour change literature offers several useful theoretical models which aim to explain or predict the likelihood of successful, individual level, lifestyle behaviour change. Indeed, research findings have shown that digital health interventions informed by these models are more likely to be effective. However, in practice adherence and engagement to web-delivered interventions is often critically low and is associated with reduced effectiveness and cost effectiveness. This thesis developed an emotional well-being intervention (ACTivate your Well-being), for inclusion within an existing lifestyle behaviour change programme ‘Champions for Health’. Thirty-eight anticipated end-users and six stakeholders contributed to a three-staged Participatory Design project which led to the development of a twelve-week intervention, based on Acceptance and Commitment Therapy, and a new study website. Development was informed by two systematic literature reviews. Feasibility and acceptability were proven in a cluster randomised control trial (ISRCTN50074817) which recruited 142 participants. The majority (74%) enrolled on at least one lifestyle behaviour change module and health improvements were observed. Almost half (43%) of those randomised to the intervention arm enrolled onto the well-being intervention. Adherence was low (7%), no one completed the full 12-week programme. A randomised control trial (ISRCTN18190978) then evaluated impact on health behaviour change, adherence and engagement, and well-being. 182 participants were recruited. Adherence remained poor (4%) however some completed the full 12-week programme. Almost half (49%) enrolled on a lifestyle behaviour change module and health improvements were observed in three modules. COVID-19 limited evaluation. The ongoing relevance of the intervention and website is evidenced through its inclusion within the Well-being In work – In work support service, Swansea Bay University Health Board.
cláusula compromissória como instrumento adequado de acesso à justiça no pós-pandemia
Authors: Ferreira Olavo Augusto Vianna Alves , Montes Netto Carlos Eduardo , Santos Filho Ronaldo Fenelon
Published: December 2021

De acordo com o ordenamento jurídico brasileiro, as partes possuem ampla liberdade para elegerem a arbitragem como método adequado de resolução das suas disputas, restando analisar se é possível, no exercício dessa autonomia, a contratação de cláusula compromissória que permita dispor da arbitragem e, no mesmo instrumento, de outras  formas de resolução de conflitos, como a justiça estatal, a depender de alguma situação  específica, a exemplo de determinado contrato ou cláusula contratual ou, ainda, do valor  envolvido na disputa e, em caso positivo, se esse instituto pode representar um efetivo  instrumento de acesso à justiça, apresentando como justificativa a grave crise que provavelmente iremos atravessar no período pós-pandemia, o aumento da utilização da via arbitral como método adequado de solução de controvérsias e a ausência de trabalhos específicos sobre o assunto, tratando-se de uma abordagem original e inédita. O método adotado foi o hipotético-dedutivo, inferindo-se, ao final, que respeitados alguns limites, a cláusula compromissória pode configurar interessante instrumento de ampliação do acesso à justiça.
Sistema prisional atual e o estímulo à despersonalização do preso
Authors: Siqueira Gilmar , Cachichi Rogério Cangussu Dantas , Leão Júnior Teófilo Marcelo de Arêa
Published: December 2021

Este artigo pretende oferecer uma pequena contribuição ao debate interdisciplinar do direito com a filosofia, concretamente a perspectiva filosófica da vida humana enquanto narrativa, do filósofo espanhol Julián Marías. A visão de Marías e seu conceito de despersonalização serão aqui trazidos para analisar o sistema prisional atual. A hipótese do artigo é que o sistema prisional, em sua prática corrente, estimula a despersonalização e com isso impossibilita o cumprimento da execução penal. O método adotado na pesquisa foi o analítico.
Resenha do livro Pandemia Direito e Fraternidade: Um Mundo Novo Nascerá
Authors: Siqueira Gilmar , Cachichi Rogério Cangussu Dantas
Published: December 2021

Resenha do livro Pandemia Direito e Fraternidade: Um Mundo Novo Nascerá. http://repositorio.asces.edu.br/handle/123456789/172
A supressão do juridiquês
Authors: Bertelli Luiz Gonzaga
Published: December 2021

Juridiquês é um neologismo em voga no Brasil, a fim de designar o emprego desnecessário e excessivo do jargão jurídico e de termos técnicos do direito. Mas, pensando nos textos de lei, podemos nos inspirar em como canta o poeta: poeta: “A beleza encontra-se na simplicidade”.
MORPHOLOGICAL PREDICTORS OF VEIN THROMBOSIS DEVELOPMENT UNDER CONDITIONS OF ONCOPATHOLOGY
Authors: P. Ya. Bodnar  , Ya. Ya. Bodnar  , Z. M. Nebesna  , Yu. V. Soroka
Published: December 2021

Nowadays pulmonary embolism is the second most common cause of death for cancer patients. The reason for this is activation of the blood coagulation system, depression of the coagulation system and fibrinolysis, decrease in the linear velocity of blood flow, phlebohypertension, as well as varicose reorganization of the vascular wall, its valves and endothelial cells. However, structural changes of veins as predictors of vein thrombosis in cancer patients are not sufficiently covered. At the same time, knowledge of these changes is important for understanding pathogenesis and prevention of thromboembolic complications. Objective: to find out the peculiarities of the restructuring of the structural components of the venous wall as a source of possible primary formation of intravascular thrombosis under conditions of oncogenic pathology. Material and methods. Histologic, submicroscopic and polarization data of the study of hind limb veins of 12 sexually mature non-linear rats - males weighing 170-180 g for 30 days of chronic neoplastic intoxication and vein fragments of 12 patients with colon cancer complicated by thrombosis were analyzed. Chronic neoplastic intoxication was simulated by subcutaneously injecting 7.2 mg / kg (based on the active substance) subcutaneously into the interscapular area once a week for 30 weeks, according to the weight of the animal at the rate of 0.1 ml of dimethylhydrazine hydrochloride solution (DMH). 10 grams of the body weight of rat 1,2-DMH (from SIGMA-ALDRICH CHEMIE, made in Japan, series D161802) pre-diluted with isotonic sodium chloride solution. Results and Discussion. Morphological studies of hind limb veins in experimental neoplastic intoxication mainly concerned submicroscopic reorganization of the endothelial cells and their desquamation, as well as platelet sweetening, which may be one of the links in pathogenesis of thrombus formation. Histological and electron microscopic examination of biopsy of the veins of patients with colon cancer found disorders of laminar intima, desquamation of endothelial cells, sclerosis of all membranes of the deep vein and neoplasm of vessels in the middle membrane. Patients with cancer are considred to have dystrophic-necrotic changes of skeletal muscle, which is one of the links in pathogenesis of hemodynamic disorders in the venous system of the lower extremities. Conclusions. The features of restructuring of the structural components of the venous wall, as a source of possible primary formation of intravascular thrombosis under conditions of oncogenic pathology include focal loss of integrity of the endothelial layer, endothelial dysfunction, sweetening of platelets, fibrotic remodeling of tunica intima, tunica media, tunica adventitia, neovascularization of tunica media, dystrophic and sclerotic changes of the skeletal muscle.
Echographic peculiarities of embryonal development in pregnant women of the group risk with genital infection
Authors: O. K. Holovachuk
Published: December 2021

The article presents the echographic features of embryonal development in pregnant women with genital infections. The estimation of ultrasonic criteria of development of embryo was conducted in the early terms of gestation: estimation of structures of the embryo, cardiac performance indicators, presence of retrochorionic haematoma. It enabled to estimate the prognosis of pregnancy and possibility of development of placenta disfunction.
Age-dependent peculiarities of echocardiographic parameters of the heart in patients with nonalcoholic fatty liver disease
Authors: Prysyazhnyuk V. P.
Published: December 2021

In present study echocardiographic features of the cardiovascular system in patients with nonalcoholic fatty liver disease (NAFLD) of different ages were examined. Structural and functional parameters of the heart change in nonalcoholic fatty liver patients with age: a progressive increase in the size of the left atrium, right ventricle, and decrease of ejection fraction. In young patients the formation of concentric remodeling and eccentric hypertrophy, in elderly patients – development of its concentric hypertrophy was observed. The above-mentioned requires timely use of cardio-protective drugs in the treatment of these patients.
Specific features of chronorhythmologic changes of the acid-regulating function of the kidneys under the hypofunction of the pineal gland
Authors: S. B. Semenenko
Published: December 2021

The paper investigates the specific features of chronorhythmologic changes of the acid-regulating function of the kidneys under the hypofunction of the pineal gland (PG). It has been established that the hypofunction of epiphysis caused disturbances of the phasic structure of the acid-regulating function in relation to chronograms of the intact group of rats.
Iron concentration in the blood serum of patients with mild and moderate craniocerebral trauma in acute and intermediate periods
Authors: M. G. Semchyshyn  , B. V. Zadorozhna
Published: December 2021

Clinical features and dynamics of changing the iron concentration in the serum of blood of patients with a traumatic brain injury have been studied.Methods. Complex clinical and para-clinical examination of 283 patients with mild and moderate traumatic braininjury in acute and intermediate periods, 20 almost healthy volunteers (control group).Results. The concentration of iron tends to decrease in the serum of blood in patients with mild and moderate braininjury in acute and intermediate periods.Area of results application. Neurology.Conclusion. The connection between iron deficit and the development of basic clinical symptoms of craniocerebraltrauma is obvious.
The private sector of health service of Ukraine is an active reserve of improving the accessibility and quality of medical care: the experience of Kirovohrad region
Authors: G. M. Ursol  , O. O. Skrypnyk  , O. M. Vasylenko
Published: December 2021

The article describes the main problems in the functioning of the health system of Ukraine, peculiarities of formation and benefits of the private sector of the health system of Ukraine and analyzes the experience of the activities of private medical organizations of Kirovohrad region.
The state of traumatism in Sumy region
Authors: V. D. Shyschuk
Published: December 2021

The article analyzed the level of traumatism in administrative districts of Sumy region. The dynamics of traumatism growth in the region was studied. The structure of injuries in administrative units of Sumy region was characterized. The groups of districts with different traumatism rate were detected.
Current aspects of vaccination of children with rheumatic diseases (reference review)
Authors: Ya. Romanyshyn  , L. Kostiuchenko  , Ya. Boiko
Published: December 2021

Vaccination is the most effective way of protection against infectious diseases. Children with rheumatic diseases (RD) are at greater risk of infection because both the disease and the therapy, administered to control it affect the functions of the immune system. The paper analyzes existing data in the literature regarding the risk of vaccine-associated autoimmune reactions, as well as the efficacy and tolerability of vaccination in children with RD. Current recommendations for immunization of children with RD, published by experts, are given.
Clinical and anthropometric analysis of anatomical and physiological condition in geriatric patients with total tooth loss
Authors: M. M. Vatamaniuk  , O. B. Belikov
Published: December 2021

The analysis of 50 pairs of plaster models of edentulous jaws in patients of both sexes aged from 75 to 90 years has been made. In 44,0 % of them the position of the jaws was neutral, in 32,0 % it was medial, and in 24,0 % – distal. A shift of the mandible relative to the upper jaw was in the range of 0,1-1,0 cm. Interalveolar height was in the range of 1,5 to 3,1 cm. There were no absolutely identical in size, shape and degree of atrophy toothless jaws.
Study of synthesis, properties and directions in use of nanoparticles and nanostructures based on semiconductors A II B VI
Authors: V. I. Fediv
Published: December 2021

The article presents the results of semiconductor nanoparticles properties investigation and its using in medicine. Results were obtained in collaboration with scientists from Chernivtsi, Ternopil, Kyiv and Linköping (Sweden). The prospects of further research and use of quantum dots are shown.
A case of acute gangrenous appendicitis complicated by phlegmonous omentitis in a child with cystic fibrosis
Authors: N. V. Rohovyk  , M. B. Zakharus  , L. Y. Bober  , B. V. Tsiupka  , B. I. Hyzha  , L. Y. Hyzha
Published: December 2021

Cystic fibrosis is one of the most common genetic diseases characterized by lesions of the exocrine glands of vital organs. There is a disturbance of ion transport and secretion is changing in electrolyte composition of target organs (bronchi, pancreas, intestines, etc.). This leads to a number of pathological conditions and their complications, including malabsorption syndrome, meconium ileus, distal intestinal obstruction syndrome, cholestasis, diseases of the respiratory tract, protein-energy deficiency. Abdominal pain is one of the most common complaints of patients with cystic fibrosis, which can mask a number of pathological conditions, including appendicitis, which is usually characterized by atypical course and it is difficult to diagnose.
Improvement of the educational process in discipline «Propedeutics of Internal Medicine» according to the credit-modular system for dentistry students
Authors: N. S. Mykhailovska  , M. A. Shalmina  , C. A. Morhuntsova  , A. V. Hrytsai
Published: December 2021

This article presents the organization of the educational process for the discipline «Propedeutics of Internal Medicine» for students majoring in «Dentistry» in accordance with the credit-modular system for the department of general practice – family medicine in the Zaporizhzhya State Medical University. It is shown that the credit-modular system of educational process provides a high level of knowledge required for the future practice of a dentist, which in turn will contribute to the ultimate goal of education – training of a qualified competitive specialist.
前言：科技興趣、超越人類與倫理限制
Authors: CAI Yu , FAN Ruiping
Published: December 2021

LANGUAGE NOTE | Document text in Chinese; abstract also in English.

人類正處於前所未有的技術高速發展時代。特別是，NBIC技術（納米技術、生物技術、資訊技術和認知科學）彙集起來的發展，使得人類改造自身、進而超越自身的夢想不斷接近現實，但也為我們敲響了倫理學的警鐘：如果我們對生命技術的不斷突破和廣泛應用所牽涉的倫理價值缺乏充分的考量並施以必要的限制，那麼技術就無法得到有利的發展和公平的應用，甚至造成過分追求那些具有不可逆結果或不可逆傷害的生命技術的後果，使得現代生物醫學成為人類幸福的一種“錯誤承諾”。本期的兩篇主題論文以及十六篇評論文章，正是著力於探討這些影響深遠的生命倫理問題。

This issue of the journal contains two thematic papers, namely “Emerging Human Embryo Research Technologies, the 14-day Rule, and the Special Status of the Embryo” by Kirstin R. W. Matthews, Sam Lowe, and Ana S. Iltis, and “A Confucian Reflection on Transhumanism: How to Regulate Our Posthuman Future?” by Wang Jue, in addition to 16 commentary essays on ethical issues associated with rapidly developing biomedical technologies. The authors argue that scientific interests should not be the main driver of technological breakthroughs and applications. Rather, ethical commitments embedded in cultural traditions should play a positive role through public participation in legitimate policymaking.
對〈新興人體胚胎研究技術、 十四天規則和胚胎的特殊地位〉一文的回應
Authors: GUO Yuyu , ZHANG Xueying
Published: December 2021

LANGUAGE NOTE | Document text in Chinese; abstract also in English.

This paper responds to “Emerging Human Embryo Research Technologies, the 14-Day Rule, and the Special Status of the Embryo” by analyzing the moral status of the embryo. We hold that the embryo has a limited moral status that is influenced by local ethical and cultural factors. The moral status of the embryo can be evaluated according to its potential value to and relationship with society within the specific ethical and cultural context. On whether the embryo should be used in research, we recommend that researchers follow the principle of permission, i.e., seek consent from the agents who best represent the interests of the embryo (usually the parents).
放棄人類胚胎“14天限制” 的倫理反駁
Authors: ZHANG Xinqing
Published: December 2021

LANGUAGE NOTE | Document text in Chinese; abstract also in English.

This article explores prominent arguments in favor of and against extending the current 14-day statutory limit on the maintenance of human embryos. I discuss the history of the 14-day limit and the reasons behind the decision to opt for a compromise between competing moral views. I then argue that the ISSCR's guidelines for extending the 14-day limit are not a valuable tool, despite their potential to contribute scientific knowledge. The importance of respecting the 14-day rule should be acknowledged by ethics committees in the current research ethics climate of mainland China.
善治視角下的人類胚胎研究政策的制訂
Authors: NIE Ye
Published: December 2021

LANGUAGE NOTE | Document text in Chinese; abstract also in English.

人類胚胎研究的“十四天規則”作為一條重要的倫理原則已實施四十餘年，被很多國家立法採納。近年來，隨著胚胎技術的飛速發展，科學家們對“十四天規則”提出了新的挑戰，也是對相關的倫理研究和公共政策的制訂提出的挑戰，即我們該怎樣看待人類胚胎研究的公共政策？Ana S litis等在〈新興人體胚胎研究技術、十四天規則和胚胎的特殊地位〉（馬修斯、洛伊、伊爾蒂斯2021）一文中鼓勵科學家從促進善治的角度來看待人類胚胎和胚狀體的研究政策，但並未深入探討其原因和意義，本文主要從善治的特徵出發通過對人類胚胎研究政策制訂中如何實現的探討而對該文的上述核心觀點進行回應。

In the article “Emerging Human Embryo Research Technologies, the 14-day Rule, and the Special Status of the Embryo,” one of the authors' core aims is to encourage scientists to look at human embryo research policy from the perspective of promoting good governance. Starting with the characteristics of good governance, this paper responds to Iltis et al. by discussing how to realize good governance in the formulation of human embryo research policy.
儒家視角下的超人類主義反思——如何監管我們的後人類未來？
Authors: WANG Jue
Published: December 2021

LANGUAGE NOTE | Document text in Chinese; abstract also in English.

隨著高科技操縱人類生命的潛力日益明顯，超人類主義運動也愈加受到學界重視，相關研究飛速增長，但尚缺乏一種基於儒家視角的系統研究。本文試圖表明儒家視角對反思超人類主義具有不可替代的重要性，不僅因為它可以幫助我們更清晰、更深刻地把握超人類主義的影響和風險，而且因為它可以在超人類主義的技術主義圖景之外，提供想像和監管我們後人類未來的另一種可能性。具體而言，本研究致力於在一種隱含比較視域下展開儒家的批判性視角，從儒家“天人合一”觀念出發，闡釋儒家為什麼不能接受超人類主義，並嘗試探索儒家反對超人類主義的倫理理由與西方生物保守主義的同異之處。由此，本文嘗試將不同文化來源的思想帶入對話中，既是通過它們分歧之處，更是要通過它們共同關懷的議題，來更好地思考，超人類主義計劃對人類社會、對人類未來意味著什麼，並回答“如何監管我們的後人類未來”這一至關重要的問題。

As the potential of high technology to manipulate human life becomes increasingly evident, the transhumanist movement is receiving greater scholarly attention, and the number of related research projects is growing exponentially. However, systematic research from a Confucian perspective is still lacking. This paper attempts to demonstrate the unique value of a Confucian perspective in reflecting on transhumanism. Confucian thought can not only help us grasp the implications and risks of transhumanism with clarity and depth but also offer alternative possibilities for imagining as well as regulating our posthuman future beyond the technocratic picture of transhumanism. Specifically, this paper develops a critical Confucian perspective in an implicitly comparative context to explain why Confucianism cannot accept transhumanism （due to the Confucian notion of “the unity of heaven and man”（天人合一）and to explore the similarities and differences between Confucian and bio-conservative perspectives on transhumanism. I thereby bring ideas from different cultural sources into dialogue to form a better understanding of what transhumanism means for human society and its future, and to answer the crucial question of how to regulate our posthuman future.
我們該如何存在？——關於超人類主義的若干批判
Authors: LIU Tao
Published: December 2021

LANGUAGE NOTE | Document text in Chinese; abstract also in English.

Transhumanism banishes the body from being, which leads to the separation of technology and virtue. In the Confucian view, the body is the symbiosis of technology and virtue, human relations and politics. We can use the notions of “benevolence” and Tao in Confucian ethics to criticize transhumanism. The fundamental problem involved in the debate between Confucianism and transhumanism concerns how human beings define themselves. Confucianists believe that human beings cannot and should not violate certain fundamental restrictions and principles presented by the universe. We should continue to think about what these fundamental restrictions and principles should be, and whether they are likely to be breached with technological progress.
CAPITAL AND MARKET: BAGAIMANA MENINGKATKAN PRODUKSI “BIHUN KUNTUL”
Authors: Gunawan Edrick Gian , Dewi Liliana
Published: December 2021

Vermicelli is a type of food originating from China, vermicelli are white noodles made from processed rice flour. Kuntul vermicelli is a rice vermicelli produced by company Gizi Pangan Nusantara. There is an increasing demand for vermicelli but the production quantity is difficult to increase, this problem can be caused by several factors, therefore the researcher will explore the factors that can affect the production of Kuntul vermicelli. The purpose of this study is to determine the factors that can affect Kuntul vermicelli production to increase the quantity of Kuntul vermicelli that can be produced. Respondents in this study are vermicelli companies registered on the website of the ministry of industry. The number of samples used was 50 respondents. The research approach was carried out quantitatively by using exploratory factor analysis method. The data collection method used a questionnaire based on 4 variables which are thought to be factors that influence the production of Kuntul vermicelli. The results of this study indicate that there are 2 factors that are formed, namely factor 1 consists of personal capital and the amount of market demand while factor 2 consists of business condition after adding capital and raw material inventory.
BUSINESS SUSTAINABILITY: HOW TO ENGAGE CUSTOMERS DURING THE PANDEMIC
Authors: Rachmasari Devi
Published: December 2021

It is a worldwide condition that corona virus spread at the end of 2019. The lockdown policy applied in most countries in the world as an effort to break the chain of spread of the virus, unfortunately, has a big impact on economics activities. The business must think hard in order to be able to sustain. Thus the writer wants to analyze a case in a language course in Surabaya to be able to survive and engage customers during the pandemic by using descriptive qualitative study with a case study. The strategy of new mindset and digital marketing is proved to be effective in making the course sustains during the pandemic of covid 19. The long distance and lockdown condition is no longer a matter since through digital marketing, the course is able to reach the public to be customers.
Multiple Object Tracking by Bounding Boxes Without Using Texture Information and Optical Flow
Authors: Lipovits Ágnes , Czúni László , Tömördi Katalin , Vörösházi Zsolt
Published: December 2021

Object tracking is a key task in many applications using video analytics. While there is a huge number of algo- rithms to track objects, there is still a need for new methods to solve the correspondence problem under certain circumstances. In our article, we assume a very typical but still open scenario: a still image object detector has already identified the objects to be tracked; thus, we have object labels, confidence values, and bounding boxes in each video frame captured at a low sampling rate. That is, optical flow methods difficult to be applied (also due to bad lighting conditions, cluttered or homogeneous areas and strong ego-motion), and moreover, many objects look similar (having the same category labels). Our proposed approach is based on the Hungarian method and incorporates the above information into the cost function evaluating the possible pairings of objects. To consider the uncertainty of the detector, the elements of the confusion matrix also contribute to the cost of pairs, as well as the probability of spatial translations based on prior observations. As a use case, we apply the algorithm to a data-set, where images were captured from onboard cameras and traffic signs were detected by RetinaNet. We analyze the performance with different parameter settings