bluuebunny/crossref_metadata_2025 huggingface dataset:
PD-L1 expression in recurrent or metastatic head and neck squamous cell carcinoma in China (EXCEED study): a multicentre retrospective study
Authors: Lu Haizhen , Kuang Dong , Zhou Ping , Zeng Jing , Xia Qingxin , Wang Jian , Duan Pei , Jiang Lili , Zang Shengbing , Jin Yiping , Jiang Xiangnan , Li Jielin , Tang Wenmin , Zhou Jiansong , Chen Jihua , Ying Jianming
Published: November 2023

Aims

Programmed death-ligand 1 (PD-L1) is known to be highly expressed in various malignancies, including head and neck squamous cell carcinoma (HNSCC). We aimed to determine the prevalence of PD-L1 expression in recurrent or metastatic HNSCC (R/M HNSCC) among Chinese patients.

Methods

This multicentre, retrospective analysis of data from six centres in China included patients with R/M HNSCC treated from 9 August 2021 to 28 February 2022. PD-L1 expression in tumour tissue was assessed and represented using a combined positive score (CPS). The χ2and Cochran-Mantel-Haenszel χ2tests were used to compare the prevalence of different PD-L1 expression statuses according to related co-variables.

Results

For all 402 examined patients with R/M HNSCC, 168 cases (41.8%) had PD-L1 expression with a CPS ≥20, and 337 cases (83.8%) had PD-L1 expression with a CPS ≥1. Between the PD-L1 CPS ≥20 group and PD-L1 CPS <20 group, statistically significant differences were observed for variables of sex (p<0.001), smoking habit (p=0.0138 for non-smokers vs current smokers) and primary tumour site (p<0.001 for hypopharynx vs oral cavity and p=0.0304 for larynx vs oral cavity, respectively).

Conclusion

PD-L1 with CPS ≥20 was expressed in about 41.8% of cases with R/M HNSCC among Chinese patients, and PD-L1 expression was significantly associated with sex, smoking history and primary tumour site. Our findings regarding the variables related to PD-L1 expression level provide insight for clinical practice and a solid basis for future research on immunotherapy in HNSCC.

Trial registration number

ISRCTN10570964.
Caring as the unacknowledged matrix of evidence-based nursing
Authors: Wang Victoria Min-Yi , Baigrie Brian
Published: November 2023

In this article, we explicate evidence-based nursing (EBN), critically appraise its framework and respond to nurses’ concern that EBN sidelines the caring elements of nursing practice. We use resources from care ethics, especially Vrinda Dalmiya’s work that considers care as crucial for both epistemology and ethics, to show how EBN is compatible with, and indeed can be enhanced by, the caring aspects of nursing practice. We demonstrate that caring can act as a bridge between ‘external’ evidence and the other pillars of the EBN framework: clinical expertise; patient preferences and values. Drawing on an influential EBN handbook, section 1 presents the aims and features of EBN, including the normative principle that EBN should take place within a ‘context of caring’. We aim to understand this context and whether it can be neatly detached from the EBN framework, as the handbook seems to suggest. In section 2, we highlight the grounds for resistance to EBN from the nursing community, before mounting the argument that nursing practices can be understood fruitfully through feminist care ethics and/or virtue ethics lenses. In section 3, we deepen that analysis using Dalmiya’s concepts of care-knowing and care as a hybrid ethico-epistemic virtue, which are ideally suited to the complex practices of nursing. In section 4, we bring this rich understanding of care into conversation with EBN, showing that its framework cannot be adequately theorised without paying proper attention to care. Caring can be neither an innocuous background assumption of nor an afterthought to the EBN framework.
What comes after strategy: Moving beyond statements and open letters – An analysis of three Toronto hospitals’ diversity, equity and inclusion (DEI) plans
Authors: Khan Bilal Noreen , Dang-Nguyen Marlena , Gordon Dara , Chandra Shivani , Omolade Abejirinde Ibukun-Oluwa
Published: November 2023

Introduction

The murders of Breonna Taylor and George Floyd in 2020 forced institutions to publicly acknowledge systemic racism. In the Canadian healthcare sector, some hospitals used this pivotal moment to create strategic equity plans to address anti-Black racism and ongoing health inequities.

Methods

Through a case study approach, we selected three hospitals in Toronto, Canada and analysed their most recent publicly available diversity, equity and inclusion (DEI) strategic plans.

Results

All three hospitals released new DEI strategies following 2020 that covered similar grounds: incorporating DEI into HR practices, cultural adaptations of services, race-based data collection and investments in training. While two out of three hospitals reported progress on their anti-Black racism commitments, specific actions to be taken and metrics to monitor and track progress varied.

Conclusions

DEI plans analysed are set to reach maturity as early as 2023 and as late as 2025. We provide high level recommendations to guide this work beyond these timelines. Antiracism reform and reconciliation is not a one-time event, but requires thoughtful planning, collaboration with communities, investment in labour (ie, resources and staff), reflection and deep reckoning.
Chronic respiratory symptoms following deployment-related occupational and environmental exposures among US veterans
Authors: Garshick Eric , Redlich Carrie A , Korpak Anna , Timmons Andrew K , Smith Nicholas L , Nakayama Karen , Baird Coleen P , Ciminera Paul , Kheradmand Farrah , Fan Vincent S , Hart Jaime E , Koutrakis Petros , Kuschner Ware , Ioachimescu Octavian , Jerrett Michael , Montgrain Phillipe R , Proctor Susan P , Wan Emily S , Wendt Christine H , Wongtrakool Cherry , Blanc Paul D
Published: November 2023

Objectives

Characterise inhalational exposures during deployment to Afghanistan and Southwest Asia and associations with postdeployment respiratory symptoms.

Methods

Participants (n=1960) in this cross-sectional study of US Veterans (Veterans Affairs Cooperative Study ‘Service and Health Among Deployed Veterans’) completed an interviewer-administered questionnaire regarding 32 deployment exposures, grouped a priori into six categories: burn pit smoke; other combustion sources; engine exhaust; mechanical and desert dusts; toxicants; and military job-related vapours gas, dusts or fumes (VGDF). Responses were scored ordinally (0, 1, 2) according to exposure frequency. Factor analysis supported item reduction and category consolidation yielding 28 exposure items in 5 categories. Generalised linear models with a logit link tested associations with symptoms (by respiratory health questionnaire) adjusting for other covariates. OR were scaled per 20-point score increment (normalised maximum=100).

Results

The cohort mean age was 40.7 years with a median deployment duration of 11.7 months. Heavy exposures to multiple inhalational exposures were commonly reported, including burn pit smoke (72.7%) and VGDF (72.0%). The prevalence of dyspnoea, chronic bronchitis and wheeze in the past 12 months was 7.3%, 8.2% and 15.6%, respectively. Burn pit smoke exposure was associated with dyspnoea (OR 1.22; 95% CI 1.06 to 1.47) and chronic bronchitis (OR 1.22; 95% CI 1.13 to 1.44). Exposure to VGDF was associated with dyspnoea (OR 1.29; 95% CI 1.14 to 1.58) and wheeze (OR 1.18; 95% CI 1.02 to 1.35).

Conclusion

Exposures to burn pit smoke and military occupational VGDF during deployment were associated with an increased odds of chronic respiratory symptoms among US Veterans.
How experiencing extreme climate change events can impact people's willingness to pay during a power outage: a case study from the Ottawa, ON 2022 derecho
Authors: Green-Mignacca Santinah , Rostami Milad , Bucking Scott
Published: November 2023

This study addresses critical gaps by evaluating willingness to pay (WTP) in Canada, the factors influencing it, and its application in averting future power outages stemming from extreme weather events. A comprehensive survey was conducted, polling 403 Ottawa residents regarding their experiences, impacts, and WTP concerning the May 2022 derecho weather and consequent power disruptions. The findings reveal a notable disparity in WTP between individuals enduring extended power outages (exceeding 4 days) and increased experienced costs. Results from a linear regression analysis show that upgrades for increased home resilience to power outages cost $590–$990/m2 more than a homeowner would be willing to pay. These results offer valuable insights for various stakeholders, aiding in projecting WTP and discerning investment thresholds for cost-effective and attainable resilience solutions, thereby facilitating the resilience enhancement process.
Unparticle effects at the MUonE experiment
Authors: Le Duc Ninh , Le Van Dung , Le Duc Truyen , Le Van Cuong
Published: November 2023

We investigate possible effects of unparticles at the MUonE experiment by considering a general model for unparticle with broken scale invariance, characterized by the scaling dimension d and the energy scale $$\mu $$
μ
at which the scale invariance is broken. Taking into account available relevant constraints on the couplings of the unparticles with the Standard Model (SM) leptons, we found that the MUonE experiment at the level of 10 ppm systematic accuracy is sensitive to such effects if $$1<d\lesssim 1.4$$

1
<
d
≲
1.4

and $$1\le \mu \lesssim 12$$

1
≤
μ
≲
12

GeV for vector unparticles. The effects of scalar unparticles are too feeble to be detected. The vector unparticles can induce a significant shift on the best-fit value of $$a_\mu ^\text {had}$$

a
μ
had

at the MUonE, thereby providing an opportunity to detect unparticles or to obtain a new bound on the unparticle-SM couplings in the case of no anomaly.
Synthesizing Computable Functions from Rational Specifications Over Infinite Words
Authors: Filiot Emmanuel , Winter Sarah
Published: November 2023

The synthesis problem asks to automatically generate, if it exists, an algorithm from a specification of correct input-output pairs. In this paper, we consider the synthesis of computable functions of infinite words, for a classical Turing computability notion over infinite inputs. We consider specifications which are rational relations of infinite words, i.e., specifications defined by non-deterministic parity transducers. We prove that the synthesis problem of computable functions from rational specifications is undecidable. We provide an incomplete but sound reduction to some parity game, such that if Eve wins the game, then the rational specification is realizable by a computable function. We prove that this function is even computable by a deterministic two-way transducer.

We provide a sufficient condition under which the latter game reduction is complete. This entails the decidability of the synthesis problem of computable functions, which we proved to be ExpTime-complete, for a large subclass of rational specifications, namely deterministic rational specifications. This subclass contains the class of automatic relations over infinite words, a yardstick in reactive synthesis.
On near-martingales and a class of anticipating linear stochastic differential equations
Authors: Kuo Hui-Hsiung , Shrestha Pujan , Sinha Sudip , Sundar Padmanabhan
Published: November 2023

The goals of this paper are to prove a near-martingale optional stopping theorem and establish solvability and large deviations for a class of anticipating linear stochastic differential equations. For a class of anticipating linear stochastic differential equations, we prove the existence and uniqueness of solutions using two approaches: (1) Ayed–Kuo differential formula using an ansatz, and (2) a braiding technique by interpreting the integral in the Skorokhod sense. We establish a Freidlin–Wentzell type large deviations result for the solution of such equations. In addition, we prove large deviation results for small noise where the initial conditions are random.
General primitivity in the mapping class group
Authors: Kapari Pankaj , Rajeevsarathy Kashyap
Published: November 2023

For [Formula: see text], let [Formula: see text] be the mapping class group of the closed orientable surface [Formula: see text] of genus [Formula: see text]. In this paper, we obtain necessary and sufficient conditions under which a given pseudo-periodic mapping class can be a root of another up to conjugacy. Using this characterization, the canonical decomposition of (non-periodic) mapping classes, and some known algorithms, we give an algorithm for determining the conjugacy classes of roots of arbitrary mapping classes. Furthermore, we derive realizable bounds on the degrees of roots of pseudo-periodic mapping classes in [Formula: see text], the Torelli group, the level-[Formula: see text] subgroup of [Formula: see text], and the commutator subgroup of [Formula: see text]. In particular, we show that the highest possible (realizable) degree of a root of a pseudo-periodic mapping class [Formula: see text] is [Formula: see text], where [Formula: see text] is a unique positive integer associated with the conjugacy class of [Formula: see text]. Moreover, this bound is realized by a root of a power of a Dehn twist about a separating curve of genus [Formula: see text] in [Formula: see text], where [Formula: see text]. Finally, for [Formula: see text], we show that any pseudo-periodic mapping class having a nontrivial periodic component that is not the hyperelliptic involution, normally generates [Formula: see text]. Consequently, we establish that [Formula: see text] is normally generated by a root of bounding pair map or a root of a nontrivial power of a Dehn twist.
Preparation of Bifunctional Nanoparticles and Evaluation of Therapeutic Function in Glioma Cells
Authors: Xu Jiaming , Zhang Jie , Li Qifeng
Published: November 2023

Small interfering RNA (siRNA)drugs have great potential in the field of anti-tumor, but they have poor biological stability and are easily degraded by nucleases in vivo, resulting in poor bioavailability. In this study, a novel albumin Poly(lactide-co-glycolide) (PLGA) nanocarrier was prepared to efficiently deliver siRNA to glioma cells to achieve tumor-targeted therapy. Recombinant VAR2CSA protein (RVP) targeting albumin PLGA nanocarriers (RVP–APN–siRNA) loaded with EGFR-siRNA were prepared by a double emulsion method. Determine its characterization performance, loading rate, in vitro release and cell uptake, and investigate the effects of nanoparticles on the cytotoxicity, proliferation and apoptosis of brain glioma cells. The prepared nanoparticles are spherical with uniform particle size, the average particle size distribution is 120–180 nm, the average potential distribution is 20–30 mv, and the loading rate is 82.36 ± 1.84%. The release rate of siRNA within 24 h is 93%, with low cytotoxicity and targeting performance, effectively inhibiting the activity of glioma cells. The prepared albumin nanoparticles have good physical and chemical properties, and have dual functions of targeted recognition of glioma cells and tumor treatment. They are efficient and safe nano-carriers for tumor-targeted treatment, and have good potential in the application of siRNA-targeted drug delivery.
Asymptotic cyclic-conditional freeness of random matrices
Authors: Cébron Guillaume , Gilliers Nicolas
Published: November 2023

Voiculescu’s freeness emerges when computing the asymptotic spectra of polynomials on [Formula: see text] random matrices with eigenspaces in generic positions: they are randomly rotated with a uniform unitary random matrix [Formula: see text]. In this paper, we elaborate on the previous result by proposing a random matrix model, which we name the Vortex model, where [Formula: see text] has the law of a uniform unitary random matrix conditioned to leave invariant one deterministic vector [Formula: see text]. In the limit [Formula: see text], we show that [Formula: see text] matrices randomly rotated by the matrix [Formula: see text] are asymptotically conditionally free with respect to the normalized trace and the state vector [Formula: see text]. We define a new concept called cyclic-conditional freeness “unifying” three independences: infinitesimal freeness, cyclic-monotone independence and cyclic-Boolean independence. Infinitesimal distributions in the Vortex model can be computed thanks to this new independence. Finally, we elaborate on the Vortex model in order to build random matrix models for [Formula: see text]-freeness and for [Formula: see text]-freeness (formerly named indented independence and ordered freeness).
A Passive Model-Based Error Compensation Approach for Bevel Tip Needle Deflection
Authors: Tavakkolmoghaddam Farid , Fischer Gregory S.
Published: November 2023

The interaction between an asymmetric (bevel) tipped needle and the surrounding tissue in image-guided percutaneous interventions, such as in prostate needle biopsy, can result in the deflection of the needle tip and cause significant targeting error. Researchers have extensively investigated different aspects of the needle-tissue interaction and proposed various solutions to mitigate this issue. While there are several promising approaches, most require complex software or hardware which makes them difficult to be deployed for clinical use. In this paper, we present a predictive model-based approach to passively compensate for undesired deflection of the needle tip prior to the initial insertion into the tissue. In this approach, an approximation of the initial deflection angle of the needle tip and the natural curvature of the needle path are utilized to simulate the insertion and predict the tip deflection prior to insertion. The model then calculates a modified needle entry point which accounts for the predicted tip deflection during the insertion. To create the model, we first collected a set of needle insertion data utilizing nonhomogeneous gelatin phantoms and ex vivo bovine tissue, using an electromagnetic (EM) tracking system and a needle with an EM sensor embedded at its tip. The collected data were then used to find the model parameters, namely, the initial deflection angle and the needle path curvature. After creating the model, a validation study consisting of two sets of insertions, one with and another without compensation, was carried out to evaluate the performance of our proposed model in compensating for the tip deflection error. The results demonstrate an average of 77% targeting accuracy improvement for insertions with modified entry points based on our model’s prediction compared with the uncompensated insertions.
Short-term learning of the vestibulo-ocular reflex induced by a custom interactive computer game
Authors: Li Qi , Xu Honglu , Chen Weicong , Su Andrew , Fu Michael J. , Walker Mark F.
Published: November 2023

This study demonstrates the feasibility and efficacy of a customized computer game to induce motor learning in the high-frequency rotational vestibulo-ocular reflex. It provides a physiological basis for the deployment of this technology to clinical vestibular rehabilitation.
Respiratory rhythm modulates membrane potential and spiking of nonolfactory neurons
Authors: Juventin Maxime , Zbili Mickael , Fourcaud-Trocmé Nicolas , Garcia Samuel , Buonviso Nathalie , Amat Corine
Published: November 2023

In this study, we evidenced strong respiratory-driven oscillations of neuronal membrane potential and spiking discharge in various nonolfactory areas of the mammal brain. These oscillations were found in the medial prefrontal cortex, primary somatosensory cortex, primary visual cortex, and hippocampus. These findings support the idea that respiratory rhythm could be used as a common clock to set the dynamics of large-scale neuronal networks on the same slow rhythm.
Clarifying the Pulmonary Arterial Morphology and Pulmonary Blood Supply in Patients with Tetralogy of Fallot and Pulmonary Atresia on Computed Tomography Angiography
Authors: Pandey Niraj Nirmal , Sinha Mumun , Verma Mansi , Ramakrishnan Sivasubramanian , Kumar Sanjeev , Jagia Priya
Published: November 2023

Aim. The present study sought to characterize the pulmonary arterial morphology and pulmonary blood supply in patients of tetralogy of Fallot and pulmonary atresia (TOF-PA) on CT angiography. Materials and Methods. We retrospectively reviewed our departmental database to identify patients with TOF-PA evaluated using CT angiography. The images were analysed to detect the presence of main and branch pulmonary arteries and pulmonary arterial confluence, presence of major aortopulmonary collateral arteries (MAPCAs), laterality and relation with pulmonary arterial morphology, and presence of patent arterial duct and associated intra- and extracardiac anomalies. Results. TOF-PA was identified in 177 patients (114 (64.4%) males; median age: 9 months). Pulmonary arteries were confluent in 142/177 (80.2%) patients. According to Somerville classification, type II pulmonary atresia was the most frequent pattern seen in 127/177 (71.8%). Based on McGoon’s ratio, pulmonary arteries were adequate for surgery in 123/177 (69.5%) patients. Patent arterial duct was present in 84/177 (47.5%) patients while MAPCAs were present in 124 (70.1%) patients, of which 72/124 (58.1%) patients had at least 1 essential MAPCA supplying either lung. According to Congenital Heart Surgeons’ Society classification, type B pulmonary arterial anatomy was the most prevalent, seen in 103/177 (57.6%) patients. Conclusion. TOF-PA is associated with marked morphologic variability in the pulmonary arterial arborization to supply the lungs. Cardiac CT angiography can accurately delineate the pulmonary arterial morphology, sources of pulmonary blood supply, and associated cardiovascular anomalies in patients with TOF-PA which aids in planning appropriate surgical management including decisions regarding the need for unifocalization of MAPCAs.
Development of a High-Sensitivity and Adjustable FBG Strain Sensor for Structural Monitoring
Authors: Qin Heying , Li Chunde , Zhu Jianqiang , Luo Boguang , Fu Feng
Published: November 2023

In this paper, a new fiber Bragg grating (FBG) strain sensor with adjustable sensitivity is invented. The sensitivity adjustment, strain sensing, and temperature compensation principles of the sensor and the corresponding formulae are developed. The prototype sensor specimen is developed, and a series of tests are performed to investigate its strain sensitivity and temperature compensation characteristics. The results show that the strain sensitivity of the sensor can be adjusted effectively by the correspondent L/LFBG parameter, with an acceptable discrepancy within ±5% of the theoretical value. The linearity, repeatability, and hysteresis were analyzed, and the errors were 0.98%, 1.15%, and 0.09%, respectively, with excellent performance. When the temperature difference was 20°C, through temperature compensation calibration, the error between the monitored strain and the actual strain was within 5% after temperature compensation correction, showing that this new type of FBG strain sensor can meet the strain monitoring needs of various engineering structures and provide reliable data acquisition.
Multiobjective and Simultaneous Two-Problem Allocation of a Hybrid Solar-Wind Energy System Joint with Battery Storage Incorporating Losses and Power Quality Indices
Authors: Moghaddam Mohammad Jafar Hadidian , Bayat Mohammad , Mirzaei Amin , Nowdeh Saber Arabi , Kalam Akhtar
Published: November 2023

In this paper, a multiobjective and simultaneous two-problem allocation of a hybrid distributed generation (HDG) system comprises of solar panels, wind turbines, and battery storage is proposed in a 33-bus unbalanced distribution network which can decrease total losses and improve power quality (PQ). The PQ indices are defined as voltage swell, total harmonic distortion, voltage sag, and voltage unbalance. In this study, the two problems of hybrid system design and its allocation in the distribution network are solved simultaneously. In the allocation problem, the HDG is placed ideally in the network to reduce energy losses and enhance PQ indices. The HDG is measured to minimize the cost of energy generation, including the initial investment, maintenance, and operation costs. The decision variable including the size of HDG components and its location is optimally determined via escaping bird search (EBS) algorithm which is inspired by the maneuvers of the swift bird to avoid predation. The results cleared that the proposed methodology using the wind and solar resources integrated with battery storage reduced the losses, voltage swell, total harmonic distortion, voltage sag, and voltage unbalance by 34.31%, 49.60%, 0.25%, 40.19%, and 2.18%, respectively, than the base network via the EBS and the results demonstrated the better network performance using all renewable resources against wind or solar application only. The outcomes demonstrated the superiority of the EBS in achieving the highest improvement of the different objectives compared with particle swarm optimization (PSO) and manta ray foraging optimization (MRFO). Moreover, the superior capability of the EBS-based methodology is proved in comparison with previous studies.
Horizontal Vibration of Pile in Transversely Isotropic Saturated Soil Based on Saturated Porous Medium Theory
Authors: Liu Linchao , Yan Qifang
Published: November 2023

In order to consider the influence of liquid phase and soil anisotropy, the soil around the pile is considered a transversely isotropic saturated porous medium, and a horizontal dynamic model of transversely isotropic saturated soil-pile is established. Based on Beor’s saturated porous medium theory and the constitutive equation of transversely isotropic media, the horizontal dynamic control equation of transversely isotropic saturated soil is obtained without considering the vertical displacement. The horizontal vibration of transversely isotropic soil layers was solved using the potential function and separation of the variable method, and the horizontal and radial displacements of the solid soil skeleton of transversely isotropic saturated soil were obtained. The horizontal force of transversely isotropic saturated soil on a single pile was also obtained. On this basis, the horizontal dynamic equation of a single pile in transversely isotropic saturated soil was established, and the horizontal vibration of the pile foundation was solved using the initial parameter method, and the horizontal dynamic impedance of a single pile in transversely isotropic saturated soil is obtained. The influence of soil anisotropy parameter, liquid-solid coupling coefficient, diameter-length ratio, and modulus ratio on the horizontal dynamic impedance of a single pile in transversely isotropic saturated soil was analyzed through numerical examples. The analysis results show that the anisotropy parameters

δ

1

, diameter-length ratio

r

0

/
H

, and modulus ratio

E

p

/

C

66

have a significant impact on the horizontal dynamic impedance of pile foundation in transversely isotropic saturated soil, and the influence of anisotropy on the horizontal vibration of pile foundation should not be ignored. The influence of the liquid-solid coupling coefficient on the horizontal dynamic impedance factor is related to frequency to a certain extent.
Angular Stability Enhancement Using Phase Compensation Method for Frequency Selective Surface Design
Authors: Chen Yiwei , Yang Yang , He Xiaoxiang , Yu Xiaohui , Zhang Wenwu
Published: November 2023

This study introduces a novel phase compensation-based, asymmetric frequency selective surface (FSS). Aimed at enhancing angular stability, the phase compensation method utilizes the reflected phase gradient changes generated by two FSSs at large grazing angles. The ultimate improvement in angular stability comes from unit amalgamation to achieve phase complementarity, effectively dealing with the phase shift of incident waves caused by large grazing angles. Based on this principle, the asymmetric FSS structure is built with 3 components: a Minkowski fractal cell, a bent-line square-loop cell, and a thin square-loop parasitic cell. Simulation results show the structure demonstrates a 0 relative shift of resonant frequency within an incidence range of 0-80° under transverse electric (TE) polarization. However, it exhibits a maximum relative shift of 5.12% in resonant frequency at an 80° incidence under transverse magnetic (TM) polarization. Compared with

E

1

and

E

2

units, this structure significantly reduces frequency deviation—by 100% at 80° incidence under TE polarization and by 80.12% and 83.26% compared with

E

1

and

E

2

units under TM polarization. Finally, the proposed FSS model was fabricated and processed, with measured data basically aligning with the simulated results.
Comparison of Three Methods for Diagnosing Trichomoniasis in Female Patients with Sexual Activity Attended at a Hospital in Peru
Authors: Rosales-Rimache Jaime , Inolopú Jorge L. , Soncco-Llulluy Fernando C. , Medina-Ciprian Leslie
Published: November 2023

Background. Trichomoniasis is a sexually transmitted infection that mainly affects women. The diagnosis is made by different methods that identify the presence of Trichomonas vaginalis; therefore, sensitivity, specificity, and performance are essential to guarantee an adequate diagnosis. Our study is aimed at comparing three methods for diagnosing trichomoniasis in patients treated at a hospital in Peru during the year 2018. Methods. We designed a cross-sectional study and enrolled women whose vaginal secretion samples were evaluated by direct examination, Papanicolaou staining, and culture in the Diamond medium. Results. We evaluated 134 women with a mean age of

36.6
±
12.1

years and a beginning of sexual activity of

18.5
±
3.0

years. We found leukocyte infiltration, fetid odor, and strawberry cervix in 66.4%, 35.1%, and 18.7%. The prevalence of trichomoniasis by the culture method, direct examination, and Papanicolaou was 32.1, 21.6, and 11.2%. The direct examination’s sensitivity, specificity, and diagnostic performance (AUC) were 65.1%, 98.9%, and 82.0%, while for the Pap smear, they were 32.6%, 98.9%, and 65.7%%. Conclusion. The culture of T. vaginalis is the gold standard for diagnosing trichomoniasis; however, direct examination is a fast, specific alternative with good diagnostic performance. The Pap test has low sensitivity and should not be used in settings where the prevalence and risk factors for trichomoniasis are high.
Diagnostic Accuracy of the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC): An Institution Experience
Authors: Rai Karima , Park Joseph , Gokhale Shamika , Irshaidat Fatima , Singh Gurdeep
Published: November 2023

The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) is a standardized system which is used to classify results of thyroid fine-needle aspiration (FNA). This system is used to evaluate and determine which patients should get thyroid surgery. It was created in order to reduce the number of patients requiring surgery. The question remains as to whether this reporting system is accurate in determining those nodules that have malignant potential and those that do not. This study is a retrospective analysis of patients in one institution who have undergone FNA and then thyroid surgery based on TBSRTC. The outcome of the pathology reports after surgery was analyzed to determine the accuracy of TBSRTC in our institution (Lourdes Hospital, Binghamton, NY). The results from our institution were compared with similar studies in other institutions to determine accuracy and reproducibility. Our results indicated that the risk of malignancy in each Bethesda category was similar to the risk percentages described for most categories in the 2017 TBSRTC update.
Supplemental Figure S2 from SETD2 Deficiency Confers Sensitivity to Dual Inhibition of DNA Methylation and PARP in Kidney Cancer
Authors: Zhou Xinyi , Sekino Yohei , Li Hong-Tao , Fu Guanghou , Yang Zhi , Zhao Shuqing , Gujar Hemant , Zu Xiongbing , Weisenberger Daniel J. , Gill Inderbir S. , Tulpule Varsha , D’souza Anishka , Quinn David I. , Han Bo , Liang Gangning
Published: November 2023

Supplemental Figure S2
Table S2 from A Cell Surface-Binding Antibody Atlas Nominates a MUC18-Directed Antibody–Drug Conjugate for Targeting Melanoma
Authors: Shi Jing , Jiao Tao , Guo Qian , Weng Weining , Ma Linjie , Zhang Qing , Wang Lijun , Zhang Jianjian , Chen Caiwei , Huang Yaling , Wang Mingqiao , Pan Rong , Tang Yanfang , Hu Wenhao , Meng Tao , Liu Shu-Hui , Guo Jun , Kong Yan , Meng Xun
Published: November 2023

MUC18 expression in normal human tissues
Table S1 from A Cell Surface-Binding Antibody Atlas Nominates a MUC18-Directed Antibody–Drug Conjugate for Targeting Melanoma
Authors: Shi Jing , Jiao Tao , Guo Qian , Weng Weining , Ma Linjie , Zhang Qing , Wang Lijun , Zhang Jianjian , Chen Caiwei , Huang Yaling , Wang Mingqiao , Pan Rong , Tang Yanfang , Hu Wenhao , Meng Tao , Liu Shu-Hui , Guo Jun , Kong Yan , Meng Xun
Published: November 2023

MUC18 expression in melanoma
Supplementary Data from Subclonal Somatic Copy-Number Alterations Emerge and Dominate in Recurrent Osteosarcoma
Authors: Kinnaman Michael D. , Zaccaria Simone , Makohon-Moore Alvin , Arnold Brian , Levine Max F. , Gundem Gunes , Arango Ossa Juan E. , Glodzik Dominik , Rodríguez-Sánchez M. Irene , Bouvier Nancy , Li Shanita , Stockfisch Emily , Dunigan Marisa , Cobbs Cassidy , Bhanot Umesh K. , You Daoqi , Mullen Katelyn , Melchor Jerry P. , Ortiz Michael V. , O'Donohue Tara J. , Slotkin Emily K. , Wexler Leonard H. , Dela Cruz Filemon S. , Hameed Meera R. , Glade Bender Julia L. , Tap William D. , Meyers Paul A. , Papaemmanuil Elli , Kung Andrew L. , Iacobuzio-Donahue Christine A.
Published: November 2023

Supplementary Figures
Microbial Regulation of Vitamin D Linked to Colorectal Cancer: A Sex Bias
Authors: Riquelme Erick , Howell Rian M. , McAllister Florencia
Published: November 2023

In a recent issue of Cancer Cell, Li and colleagues revealed that Carnobacterium maltaromaticum (C. maltaromaticum) was significantly depleted in the stool samples of patients with colorectal cancer in a female-specific manner. C. maltaromaticum actively participated in the generation of vitamin D intermediary metabolites, which together with Faecalibacterium prausnitzii and Lachnispiraceae bacterium produce an active metabolite of vitamin D that protects against colorectal cancer development. C. maltaromaticum supplementation induced in a female-specific manner an increase in vitamin D levels that would activate its receptor in the colonic epithelium, protecting against the development of colorectal cancer.
Unsatisfactory Fecal Immunochemical Tests for Colorectal Cancer Screening: Prevalence, Reasons, and Subsequent Testing
Authors: Liu Po-Hong , Nair Rasmi G. , Skinner Celette Sugg , Murphy Caitlin C. , Kim Eric J. , Ortiz Cynthia , Wang Lei , Hu Ellen , Lykken Jacquelyn M. , Levin Theodore R. , Green Beverly B. , Hahn Erin E. , Santini Noel , Halm Ethan A.
Published: November 2023

Background:

Fecal immunochemical test (FIT) is an effective colorectal cancer screening modality. Little is known about prevalence, reasons, and testing after unsatisfactory FIT, or a FIT that cannot be processed by the laboratory due to inadequate stool specimen or incomplete labeling.

Methods:

Our retrospective cohort study examined unsatisfactory FIT among average-risk individuals aged 50–74 years in a large, integrated, safety-net health system who completed an index FIT from 2010 to 2019. We determined prevalence of unsatisfactory FIT and categorized reasons hierarchically. We used multivariable logistic regression models to identify factors associated with: (i) unsatisfactory FIT; and (ii) subsequent testing within 15 months of the unsatisfactory FIT.

Results:

Of 56,980 individuals completing an index FIT, 10.2% had an unsatisfactory FIT. Reasons included inadequate specimen (51%), incomplete labeling (27%), old specimen (13%), and broken/leaking container (8%). Unsatisfactory FIT was associated with being male [OR, 1.10; confidence interval (CI), 1.03–1.16], Black (OR, 1.46; CI, 1.33–1.61), Spanish speaking (OR, 1.12; CI, 1.01–1.24), on Medicaid (OR, 1.42; CI, 1.28–1.58), and received FIT by mail (OR, 2.66; CI, 2.35–3.01). Among those with an unsatisfactory FIT, fewer than half (41%) completed a subsequent test within 15 months (median, 4.4 months). Adults aged 50–54 years (OR, 1.16; CI, 1.01–1.39) and those who received FIT by mail (OR, 1.92; CI, 1.49–2.09) were more likely to complete a subsequent test.

Conclusions:

One in ten returned a FIT that could not be processed, mostly due to patient-related reasons. Fewer than half completed a subsequent test after unsatisfactory FIT.

Impact:

Screening programs should address these breakdowns such as specimen collection and labeling to improve real-world effectiveness.

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Published: November 2023

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Published: November 2023

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Digital Storytelling in Teaching Filipino Subject in Grade 7 Students
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Published: November 2023

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This paper examined the various factors proposed in the literature that have potential to impact consumer behaviour within the context of e-commerce platforms. The field of consumer behaviour involves the analysis of the actions and reactions of individual consumers in response to business practises. This is particularly pertinent within the realm of e-commerce and online retail, as they differentiate themselves from traditional commerce by virtue of their unique functionalities and characteristics. It is worth noting that e-commerce has the ability to distinctly impact consumer behaviour. By employing questionnaire surveys to gather data and evidence, followed by conducting various forms of analysis such as descriptive and inferential analysis, we have ascertained that consumer behaviour can be positively influenced by factors such as sales and promotion, a favourable reputation of the e-commerce retailer, and a satisfactory user experience. This study has effectively identified the distinctive factors that empower e-commerce retailers to exert influence over consumer behaviour. It is suggested that these findings possess the potential to contribute significantly to the current body of knowledge on e-commerce retailing.