bluuebunny/crossref_metadata_2025 huggingface dataset:
NILAI MORAL DALAM NOVEL KAU, AKU, DAN SEPUCUK ANGPAU MERAH KARYA TERE LIYE
Authors: Amral Sainil , Anjelina Maya
Published: June 2023

This study aims to describe the moral values in the novel Kau, Aku, Dan Sepucuk Angpau Merah by Tere Liye (Content Analysis Study) which refers to 6 aspects of moral values of human relations with fellow humans including, positive thinking, helping others, love, helping the weak selflessly, knowing each other, and respecting each other. This research uses descriptive qualitative research. The data used in this research are primary data and secondary data. Primary data is a fact that can be used as material for research, namely from dialog, narration, and events that contain moral values contained in the novel Kau, Aku, Dan Sepucuk Angpau Merah by Tere Liye. Based on the results of research and discussion, it can be concluded that the moral values in the novel Kau, Aku, Dan Sepucuk Angpau Merah by Tere Liye, there are moral values of positive thinking aspects as many as 45 quotations, aspects of helping others as many as 22 quotations, love as many as 48 quotations, helping the weak selflessly as many as 6 quotations, knowing each other as many as 11 quotations, respecting each other as many as 26 quotations. From the six aspects of moral values, a total of 158 quotations were collected. The most dominant moral value found is the moral value of positive thinking and love. Thus, the novel Kau, Aku, dan Sepucuk Angpau Merah by Tere Liye is inspired by the basic thoughts of positive thinking and love.
NILAI MORAL TOKOH SATYA DALAM NOVEL SABTU BERSAMA BAPAK KARYA ADHITYA MULYA
Authors: Utami Wiwik Surya
Published: June 2023

Literary work is the result of the creation of the author or writer to be enjoyed and understood in the social life of society. The researcher chose the novel Saturday Together with Mr. Adhitya Mulya, a novel that has many moral values, this novel has 4 main characters, namely Mr. Gunawan Granida, Mrs. Itje, Satya and Cakra. This study only focuses on the character Satya, the eldest son of Pak Gunawan Granida. The purpose of this study was to describe the moral values of the Satya character in the novel Saturday Together with Mr. This research is a qualitative descriptive study using the method of listening and noting. The results of this study contained 5 moral aspects of human relations with oneself, namely morally responsible behavior, patience, controlling emotions, working hard, regret and admitting mistakes (apologies). Then, there are 3 moral aspects of human relations with other humans in the social and natural environment. Satya exhibits compassionate, caring and caring moral behavior. And in one aspect of the relationship between humans and God, there is not much moral behavior that leads to the relationship between humans and God, only shown in Satya's attitude to remind his children to worship.
Gemelos Parápagos Dicéfalos: Reporte de Caso
Authors: Ruiz Jumbo Karla Leonela , Madrid Montesdeoca José Efrén , Guerrero Cevallos Esteban Rigoberto
Published: June 2023

Introducción: Los gemelos siameses hacen referencia de la presencia de dos fetos unidos entre sí en distintas zonas anatómicas por consecuencia de una imperfecta separación del disco embrionario que normalmente sucede alrededor del día 13 de la concepción. Antecedentes: Se presenta de manera rara que acontece en 1 por cada 100,000 nacimientos. La clasificación depende del sitio de unión de los gemelos. Para el diagnóstico se requiere imágenes ecográficas de amplio espectro minucioso debido que se puede visualizar otras patologías acompañantes presentes en los gemelos. Presentación de caso: Gemelos parápagos dicéfalos, sin controles prenatales previos en el cual llegó a emergencia por dolor tipo contráctil de moderada intensidad en hipogastrio irradiado a región lumbrosacra, se realizó un eco obstétrico donde reporta producto único bicéfalo presentación, latidos cardíacos presentes 149 por minuto, vejiga, estómago único, riñones fetales normales, tórax normal presente dos columnas vertebrales, un corazón con cuatro cámaras, manos normales, piernas en varo y pies equinovaro. Conclusión: Con la siguiente revisión de caso, pretendo llegar a todo el personal de salud con el claro objetivo de proporcionar información actualizada del diagnóstico, manejo y tratamiento de gemelos parápagos dicéfalos. Área de estudio general: medicina. Área de estudio específica: ginecología y obstetricia.
Efficacy of Autologous Blood Clot in Primary Pterygium Excision Compared with Suture Technique
Authors: Tanzin Tanuja , Iqbal Md Iftekher
Published: June 2023

Background: To assess the efficacy of pterygium excision and conjunctival autograft surgery among patients underwent autologous blood clot or using sutures (10-0 monofilament nylon).   

Materials and methods: A randomized controlled trial was done at Department of Ophthalmology, Chittagong Medical College Hospital, with a study period from February 2017 to November 2018 was conducted with 60 eyes from 60 patients having primary nasal pterygium. They were selected according to inclusion and exclusion criteria and randomized into two groups for conjunctival autograft. Group A (30) was treated with autologous blood clot and Group B (30) was treated with sutures (10-0 monofilament nylon). All surgeries were performed by a single surgeon at single center. Standard examinations were performed preoperatively and postoperatively, preoperative and postoperative outcomes were evaluated and compared statistically where follow up was done at 1st day,7th days, 1-month, 3-month, and 6-month post operation. The mainoutcome variables were postoperative discomfort, graft stability and complications.  

Results: This study included 60 patients (60 eyes) with a mean age of 46.77±7.04 (SD) (Range 33 to 58 years) in Group A (30) and 46.17±7.53 (SD) (Range 22 to 58 years) in Group B (30). In Group A, male was 22 (73.3%) and female was 8 (26.7%) where Group Bcontained male 20 (66.7%) and female 10 (33.3%). Follow-up at 1st and 7th post operation days showed marked discomfort in Group B (Mean rank 41.82 and 40.62) compared to Group A (Mean rank 19.18 and 20.38) respectively (p<0.001). At 1st post operation day there were 3 (10%) graft retraction in Group Aonly. Within 6 months follow-up, all grafts were stable and there wasonly 1 (3.3%) granuloma in Group B.  

Conclusion: In primary pterygium excision, autologous blood clot showed excellent post- operative outcomes with much comfort, more stableas well as fewer complications. So, it appears to be an effective means to treat primary pterygium surgically.

JCMCTA 2020 ; 31 (1) : 42-47
Histomorphological Study of Nephrectomy Specimens in a Tertiary Care Hospital Of Chattogram: An Observational Study
Authors: Nasreen Sayeeda , Sadaf Anika , Ahamad Shahab Uddin , Rahman Md Zillur
Published: June 2023

Background: Now a-days nephrectomy is not an uncommon surgery practiced in urology. Not only the clinical suspicions are confirmed but also many unsuspecting lesions are brought to light by the histopahological study.Elective nephrectomy is done for both benign and malignant diseases of the kidney. On the other hand, trauma is the most common cause of emergency nephrectomy. To observe the demographic and histopathological aspects of nephrectomy specimens in a tertiary care hospital of Chattogram: Chittagong Medical College Hospital.

Materials and methods: This was an observational study of nephrectomy specimens received in the Department of pathology, Chittagong Medical College over a period of one year (January to December 2019). The studied parameters were: frequency, age, sex, laterality, clinical presentation, histological type and morphologic characteristics.

Results: There were 30 nephrectomy specimens of which 09 were non-neoplastic and 21 were neoplastic lesions. Among the neoplastic lesions, all the cases were malignant with no significant side and sex differences of patients. The most frequent (26.67%) age rage was 0-10 year and renal cell carcinoma was the commonest (13 out of 21 cases, 61.90%) malignant tumor. Among the nonneoplastic lesions, chronic pyelonephritis was the most frequent benign lesion (5 out of 9 cases, 55.56%).

Conclusion: In this study, there was a much higher rate of nephrectomy performed for malignant conditions of the kidney compared to other developing countries, where benign lesions are the main cause of nephrectomies.

JCMCTA 2020 ; 31 (1) : 58-63
Neovascular Glaucoma Associated with Chronic Rhegmatogenous Retinal Detachment
Authors: Kim Dong Ik , Kim Min Seok , Woo Se Joon
Published: June 2023

Purpose: To demonstrate the clinical features and natural course of chronic retinal detachment-associated neovascular glaucoma.Methods: Ten patients, diagnosed with chronic retinal detachment-associated neovascular glaucoma during 2007-2016 were retrospectively investigated. Besides chronic retinal detachment, no patients had any neovascular glaucoma-predisposing conditions, such as carotid artery disease. Retinal perfusion status was evaluated from the fundus fluorescein angiography images.Results: The mean age of patients was 57.5 years (range, 22-78 years). Complete retinal reattachment was achieved in three eyes, while partial or total chronic retinal detachment persisted in seven eyes. Wide-angle fundus fluorescein angiography revealed peripheral retinal capillary obstruction and severe nonperfusion. Neovascular glaucoma developed 213.4 months (range, 17-634 months) after retinal detachment. Three eyes received Ahmed valve implantation, while five eyes received intravitreal bevacizumab injection. Intraocular pressure was controlled in 10 eyes. Two eyes developed phthisis bulbi during follow-up.Conclusions: In eyes with a chronic retinal detachment history, iris neovascularization and neovascular glaucoma can develop due to retinal capillary obstruction and chronic retinal ischemia, even after achieving retinal reattachment. We suggest regular follow-up examinations for patients with chronic retinal detachment, particularly for eyes with retinal nonperfusion, as detected on fundus fluorescein angiography.
Associations between Parental Conflict and Externalising Behaviours in Children with ASD in a Local Singaporean Sample: Parenting Style as a Moderating Mechanism
Authors: Farveen Abusalih Ayessha , M. Y. Tan Eunice , De Cruz Nicholas
Published: June 2023

The present study examined the associations between parental conflict and externalising behaviours, specifically in children with Autism Spectrum Disorder (ASD). In addition, parenting styles is explored to moderate the relationship between parental conflict and externalising behaviours in these children with Autism Spectrum Disorder(ASD). Participants comprised of 106 parents of Singaporean children with ASD. Parents were required to complete assessments of autism severity, externalising behaviours, parenting style and interparental conflict. The results from the regression analyses and ANOVA reveal that parenting styles can reduce externalising behaviours in children with ASD, in the context of parental conflict. The findings from the study have implications in designing targeted interventions and parent training programmes to equip parents with appropriate skills to nurture their child, thereby reducing the detrimental outcomes of parental conflict.
Anemia ferropriva no Estado do Maranhão: uma análise entre 2018 e 2022
Authors: Araújo Sandra Regina Machado , Cunha Euzite Rabelo , Marques Iranete Lopes , Paixão Simone Alves , Dias Alice de Fátima Gomes , Sousa Patrícia Martins de , Soares Nayara de Kassya Pinheiro , Sousa Maria Olivia , Lobato Rutileia Moura , Souza Maria Tereza Pereira de
Published: June 2023

Objetivos: Identificar o perfil epidemiológico da Anemia Ferropriva no Estado do Maranhão entre 2018 e 2022. Metodologia: Trata-se de um estudo epidemiológico, retrospectivo e descritivo baseado em dados obtidos no Sistema de Informações Hospitalares do Departamento de Informática do Sistema Único de Saúde (SIH/DATASUS). Resultados: Certificou-se que ocorreram 1.628 internações por anemia ferropriva no Maranhão no período entre janeiro de 2018 e dezembro de 2022 e houve 15 óbitos por essa afecção nesse intervalo de tempo. Além disso, foi possível observar que a faixa etária mais afetada foi de 30 a 39 anos e 40 a 49 anos. Quanto ao sexo, o feminino mostrou maior número de afetados com 59% do total. Por fim, observou-se um aumento gradual da incidência dessa anemia na população analisada entre 2018 e 2022. Conclusão: a anemia por deficiência de ferro é prevalente na população do Estado do Maranhão, principalmente em pacientes acima de 20 anos, do sexo feminino e de etnia parda, possuindo suas internações mais concentradas nas regiões Codó, São Luís e Pedreiras.
Utilização de aprendizagem supervisionada de máquina para predição de valores genéticos com base em duas gerações de ascendentes
Authors: Dijkinga Fernando Jean
Published: June 2023

Uma eficiente utilização de ferramentas que visam acelerar o melhoramento genético como o acasalamento direcionado requer informações de valores genéticos tanto de reprodutores quanto de mães, porém a baixa acurácia ou a carência desta pode comprometer programas de melhoramento genético, dessa forma, estimar valores genéticos de fêmeas é desafiador. Metodologias que utilizem apenas informações de ascendentes machos para o cálculo de valores genéticos de fêmeas já foram propostos, porém, com o surgimento de tecnologias de aprendizado de máquina supervisionado possibilitaram relevantes ao melhoramento genético. Portanto este trabalho tem como objetivo avaliar metodologia baseada em um algoritmo supervisionado de regressão linear em função do método consolidado em literatura, podendo ser empregado em programas de melhoramento genético. Os resultados de análise de correlação de Pearson foram todos significativos (p<0,0001) entre valores preditos de ambos os modelos e valores reais, demonstrando que ambos os modelos podem ser utilizados para estimar valores genéticos. Porém ao utilizar o modelo baseado em aprendizagem de máquina foi possível constatar erros com menores desvios-padrão para as características de leite, gordura, proteína e vida produtiva, e iguais para as demais características analisadas, indicando que modelos utilizando tecnologias derivadas de aprendizagem de máquina possuem aplicações promissoras no melhoramento genético.
REVIEW OF MANAGEMENT INFORMATION SYSTEMS USING EXPERT SYSTEMS IN INTERNAL CONTROL FOR INDONESIA'S BUREAUCRATIC REFORM
Authors: Sinulingga Minan , Djati Sundring Pantja , Thamrin Suyono , Saragih Herlina Juni Risma , Wijaya Hendy Risdianto
Published: June 2023

Technological developments are driving changes in bureaucratic reform, through Presidential Regulation No. 81 of 2020 which targets that by 2025 a system of oversight and accountability will be created to create a government with high integrity. Increasing SPBE (Electronic Based Government System) by implementing MIS (Management Information System) is one of the keys to achieving this target. This study aims to examine the use of MIS for internal control (SIMWAS) using an expert system, especially for internal audits associated with bureaucratic reform in Indonesia. This research method uses a Systematic Literature Review (SLR) to find suitable articles from various sources from 2015 to 2021 and conducts a Trend Analysis of the SLR results and a total of 31 articles to find research trends. The results of this study indicate that there is still no research related to supervision and internal auditors associated with bureaucratic reform and performance. Research on internal audits to improve performance using SIMWAS using an expert system has also not been done yet. This research can be developed using artificial intelligence to evaluate, predict and improve the performance of internal auditors that impact organizational performance. This study shows that the use of MIS for internal control using an expert system for internal audit still needs to be improved to support bureaucratic reform, especially the increase in SPBE.
The pacemaker activity of interstitial cells of Cajal and gastric electrical activity
Authors: Čamborová P , Hubka P , Sulková I , Hulín I
Published: June 2023

Interstitial cells of Cajal (ICC) are the pacemaker cells in the gut. They have special properties that make them unique in their ability to generate and propagate slow waves in gastrointestinal muscles. The electrical slow wave activity determines the characteristic frequency of phasic contractions of the stomach, intestine and colon. Slow waves also determine the direction and velocity of propagation of peristaltic activity, in concert with the enteric nervous system. Characterization of receptors and ion channels in the ICC membrane is under way, and manipulation of slow wave activity markedly alters the movement of contents through the gut. Gastric myoelectrical slow wave activity produced by pacemaker cells (ICC) can be reflected by electrogastrography (EGG). Electrogastrography is a perspective non-invasive method that can detect gastric dysrhythmias associated with symptoms of nausea or delayed gastric emptying.
TGF-beta1 expression and chronic allograft nephropathy in protocol kidney graft biopsy
Authors: Viklický O , Matl I , Voska L , Böhmová R , Jarešová M , Lácha J , Lodererová A , Stříž I , Teplan V , Vítko Š
Published: June 2023

Chronic allograft nephropathy (CAN) represents a frequent and irreversible cause of long-term renal graft loss. TGF-beta1 is a key profibrogenic cytokine associated with CAN pathogenesis. Because of clinical diagnostic inaccuracy, protocol biopsy has been suggested to be a beneficial method for early CAN detection. Protocol core biopsy was carried out in 67 consecutive cyclosporine-based immunosuppression-treated kidney transplant recipients with stable renal function 12 months after renal transplantation. Biopsy specimens were analyzed morphologically according to Banff-97' criteria and immunohistologically for TGF-beta1 staining. The data obtained were correlated with plasma TGF-beta1 levels and clinical data. CAN (grade I-III) was found in 51 patients (76 %). CAN grade I was found to be the most frequent one (44 %). A normal finding within the graft was made in only 12 patients (18 %). Clinically silent acute rejection Banff IA was present in 4 patients (6 %). In 8 patients (12 %) with CAN, borderline changes were present. We found a significant correlation between CAN grade and creatinine clearance, as measured by the Cockroft-Gault formula (p<0.01) as well as body mass index (p<0.01). There was a significant correlation between chronic vasculopathy (Banff cv) and creatinine clearance, and between the degree of TGF-beta1 staining and chronic vasculopathy (p<0.01). There were no relations between morphological findings and TGF-beta1 plasma levels, cyclosporine levels, plasma lipids, HLA-mismatches, panel reactive antibodies (PRA), proteinuria, and the donor's age. In conclusion, CAN is a frequent finding in protocol kidney graft biopsies 12 months after transplantation. TGF-beta1 tissue expression is linked with chronic vasculopathy.
On Frankenstein and How (Not) to Be a Queer Parent
Authors: Heggestad Jon
Published: June 2023

Reflecting on Mary Shelley’s Frankenstein (1818) nearly two centuries after its original publication, Ernest Larsen observes that Shelley ‘opened the lid on a new way of thinking about pregnancy – the narrative in which a male gives birth to a monster’ (236). And while we might regard such a narrative as inherently queer, the queerness of Victor Frankenstein’s methods for cultivating life are rarely explored. This article aims to remedy this gap in the abundant scholarship surrounding the novel. In negotiating feminist readings (which have historically highlighted the role of reproduction in the novel while ignoring or indemnifying Victor Frankenstein’s queerness) and queer and trans readings (which better recognise the novel’s alternative affirmations), this work ultimately highlights the novel’s exploration of queer generativity – an effort that is muddied not by the protagonist’s methods but by his own irresponsibility and failures in character. Although the focus of this work remains on the critical response to Frankenstein, it concludes by suggesting ways in which future scholarship might adopt the analytical framework outlined here in further engagement with the text.
Decadent Constantinople: Symons, Flecker, and Nicolson
Authors: Murray Alex
Published: June 2023

This article examines the work of three British writers – Arthur Symons, James Elroy Flecker, and Harold Nicolson – who all spent time in Constantinople in the first two decades of the twentieth century. Drawing on the Decadent literary aesthetic, they registered their distaste for a city then synonymous with decline. In their poetry, impressionistic prose, and fiction they struggle to write about a city that seemed so amenable to a literature of exhaustion and decay. I argue that the work of Symons and Flecker reveals something like a limit point to the development of literary Decadence. Rather than be a vehicle for affective, cosmopolitan community, Decadence encouraged solipsism and melancholy, a legacy that lives on in literary modernism. Their exhausted Decadence is then satirised by Nicolson who sees late-Victorian aestheticism as ill-equipped to deal with the geopolitical complexities of the city by the Bosphorus.
Confronting the Competition in the Labor Market: An Interview Study about Vietnamese Workers versus Questionnaire Responses from Taiwanese Workers in Taiwan
Authors: Nguyen Hai Nhi
Published: June 2023

Due to the Taiwanese government’s Immigration Worker Policy, the entry of foreign workers these years caused specific competition for both local and alien laborers in Taiwan. With an aged population, low birth rate, and more high-educated people, Taiwan is facing serious labor shortages in many sectors. While many Taiwanese citizens are not willing to serve in manual or blue-collar jobs. To fill these vacancies, the Taiwanese government has been implementing policies for attracting expats to work. As a result, Taiwan has become a destination for workers from different nations to pursue and develop their careers. However, the existence of these alien workers led to competition with the local ones.
Upaya Pencegahan Anemia pada Remaja Putri melalui Penggunaan Video Animasi
Authors: Sari Yulia , Santi Mina Yumei , Purbowati Niken , Fitriana Shentya
Published: June 2023

Introduction: Anemia causes decreased endurance, fatigue, weakness, lethargy, negligence, impaired concentration in learning and worsening academic achievement. The lack of knowledge of young women has an impact on negative attitudes towards efforts to prevent anemia. Purpose: To determine the effect of balanced nutrition animated videos on efforts to prevent anemia in young women. Purpose: To determine the effect of balanced nutrition animated videos on efforts to prevent anemia in young women. Methods: Quantitative research using a quasi-experimental design with a pretest-posttest approach with a control group design. A sample of 50 female adolescents in each group was determined using a proportional random sampling technique, then the knowledge and attitude scores of adolescents were measured before and after treatment. Data analysis used the independent t test. Results: The average score of female adolescents' knowledge about efforts to prevent anemia in the treatment group that was given the intervention was higher than the control group (p=0.0001). The average score of the attitudes of young women regarding efforts to prevent anemia in the treatment group was higher than that of the control group (p=0.0001). Conclusion: Animated video on balanced nutrition can be used as an extension medium in providing education to students, especially young women, in preventing anemia.
Pembentukan GELAS KACA (Gerakan Lansia Kelola, Adaptasi, Cegah dan Tangguh) Selama Pandemi Covid-19
Authors: Suharto Dewi Nurviana , Manggasa Dafrosia Darmi
Published: June 2023

The increase in the number of COVID-19 cases took place quite quickly, and spread to various districts in Indonesia in a short time including Poso Regency. The elderly and those with comorbidities are at risk of contracting and experiencing worse complications due to COVID-19. Therefore, it is very important to prevent transmission through promotive and preventive efforts to the elderly, both at the family, community and health facilities levels. To achieve this, one of them is through the establishment of GELAS KACA (Gerakan Elderly Manage, Adapt, Prevent and Resilient), which aims to increase the knowledge of the elderly in preventing the transmission of COVID-19. The problems that the elderly do not know how to manage illness during the pandemic, the elderly feel stressed because they have to stay at home, only health services are carried out if it is really important, the observation results show that there are also some elderly people who are afraid to go to health services for fear of being diagnosed with COVID -19. This is the basis for the implementation of the service which aims to establish GELAS KACA (The Elderly Movement for Managing, Adapting, Preventing and Resilient). The service is carried out by providing education on preventing COVID-19 transmission, self-management, adapting new habits and stress management, then evaluating the knowledge of the elderly after being given education. The results of the service showed that knowledge increased to 95%, psychosocial problems obtained were neurosis symptoms as much as 100%.
Pelatihan Konselor Remistar (Remaja Milenial Tanpa Asap Rokok) Sebuah Inovasi Pencegahan Merokok pada Remaja di Kota Singkawang
Authors: Sulistyawati Dwi , Akhmad Arif Nur , Yuniar Lily
Published: June 2023

Teen smokers in Indonesia have increased every year. This condition can occur because teenagers are more likely to show themselves as adults by starting to smoke. REMISTAR Counselor Training is an effective intervention about smoking in adolescents. This community service aims to make adolescents as counselors who are able to carry out promotive, preventive, and curative actions. A total of 80 samples of respondents from 2 selected high schools in Singkawang City, West Kalimantan Province will be given REMISTAR counselor training. The implementation of this community service is divided into two places, namely at MAN 1 Singkawang and SMAN 3 Singkawang which is carried out within 10 months starting from proposal preparation, licensing, intervention, data analysis to report collection. The implementation of this service is evaluated based on the level of knowledge, attitudes related to smoking, and skills. The results of the REMISTAR Training activity were an increase in respondents' knowledge in the form of an increase in knowledge about smoking as many as 70 people (87.5 %), knowledge about Counselors 57 people (71.5%) and an increase in attitudes of 78 people (96.6%) in good category. In conclusion, training of remistar counselors (millennial youth without smoking) is effective in increasing the knowledge and attitudes of millennial youth. It is hoped that after this training activity it will be the start for students to become agents of change who can actually become smoking cessation counselors for friends around them who still cannot quit smoking.
Edukasi Patient Safety pada Pasien dan Keluarga Pasien di Instalasi Poliklinik Rumah Sakit Umum Daerah Sayang Rakyat Kota Makassar
Authors: Rachmawaty Rini , Hamid Firdaus , Gaffar Indra , Tombong Andi Baso , Razak Poppy Nurul Asmaul , Angraini Fatima
Published: June 2023

In 2019, data was obtained that there were 12 cases of Potential Injury Events (KPC) at RSUD Sayang Rakyat. Therefore, RSUD Sayang Rakyat is the target of Patient Safety Education activities for patients and their families at the Polyclinic. The aim of carrying out community service is to prevent and reduce risks, errors and losses that occur to patients during the provision of health services. This community service uses educational methods for polyclinic patients and families using video and flayers and is simulated directly to patients and families. Besides that, to measure patient and family understanding before education, they are given a pre-test and after education, it is given a post-test which consists of 6 multiple choice questions related to 6 patient safety goals in the hospital. The evaluation results obtained after 3 times of education showed significantly increased knowledge of patients and patient families compared to before education with values 0,529 (p= 0,041) in education 1, 0,8 (p=0,046) in education 2 and 0,692 (p=0,041) in education 3  it is hoped that hospitals will pay more attention to and improve patient safety in hospitals in order to prevent incidents to patients.
Pelatihan Pengisian Kartu Skor Poedji Rochjati pada Ibu Hamil dalam Deteksi Dini Risiko Tinggi Kehamilan
Authors: Anita Wan , Pratwi Ayu Sri , Zalni Rummy Islami , Najmi Elsa Hayatun , Elna Julia
Published: June 2023

Maternal mortality in Indonesia is still high where maternal mortality can be prevented. Various complications that arise during pregnancy, childbirth and postpartum can be detected as early as possible so that delays in complications can be reduced. The Poedji Rochjati Score Card (KSPR) is an effort to detect early complications in mothers as well as evidence of recording and reporting by midwives in finding complications cases. The purpose of the service is to provide skills for pregnant women in detecting the condition of pregnant women as early as possible through filling out the Poedji Rochjati Score Card. The court activity was attended by 10 pregnant women who were held at the Muda Setia Poskesdes, Bandar Sei Kijang District, Pelalawan Regency. The results of the service show the ability of pregnant women to carry out early detection through filling out the KSPR as many as 3 pregnant women. that training for pregnant women in using the Poedji Rochjati Scorecard is very necessary, because with pregnant women knowing every development of pregnancy every month, pregnant women become more concerned about the possible risks of pregnancy that might arise and immediately have their pregnancies checked by health workers. It is hoped that health workers, especially midwives, will be able to provide ongoing counseling to increase the knowledge of pregnant women in early detection of pregnancy risks through KSPR so that mothers can recognize earlier the risks of pregnancy that are being experienced so that pregnant women immediately check their pregnancies.
Tsetse fly inspired steerable bone drill—a proof of concept
Authors: de Kater Esther P. , Müller Rob , Sakes Aimée , Breedveld Paul
Published: June 2023

The fixation strength of pedicle screws could be increased by fixating along the much stronger cortical bone layer, which is not possible with the current rigid and straight bone drills. Inspired by the tsetse fly, a single-plane steerable bone drill was developed. The drill has a flexible transmission using two stacked leaf springs such that the drill is flexible in one plane and can drill along the cortical bone layer utilizing wall guidance. A proof-of-principle experiment was performed which showed that the Tsetse Drill was able to successfully drill through 5, 10 and 15 PCF cancellous bone phantom which has similar mechanical properties to severe osteoporotic, osteoporotic and healthy cancellous bone. Furthermore, the Tsetse Drill was able to successfully steer and drill along the cortical wall utilizing wall guidance for an insertion angle of 5°, 10° and 15°. The experiments conclude that the tsetse fly-inspired drilling method is successful and even allows the drilling along the cortical bone layer. The Tsetse Drill can create curved tunnels utilizing wall guidance which could increase the fixation strength of bone anchors and limit the risk of cortical breach and damage to surrounding anatomy.
Comprehensive analysis of differences in N6-methyladenosine RNA methylomes in Helicobacter pylori infection
Authors: Li Huan , Lin Jiahui , Cheng Sha , Chi Jingshu , Luo Ju , Tang Yu , Zhao Wenfang , Shu Yufeng , Liu Xiaoming , Xu Canxia
Published: June 2023

Background:Helicobacter pylori (H.pylori) infection is an important factor in the occurrence of human gastric diseases, but its pathogenic mechanism is not clear. N6-methyladenosine (m6A) is the most prevalent reversible methylation modification in mammalian RNA and it plays a crucial role in controlling many biological processes. However, there are no studies reported that whether H. pylori infection impacts the m6A methylation of stomach. In this study, we measured the overall level changes of m6A methylation of RNA under H. pylori infection through in vitro and in vivo experiment.

Methods: The total quantity of m6A was quantified in gastric tissues of clinical patients and C57 mice with H. pylori infection, as well as acute infection model [H. pylori and GES-1 cells were cocultured for 48 h at a multiplicity of infection (MOI) from of 10:1 to 50:1]. Furthermore, we performed m6A methylation sequencing and RNA-sequencing on the cell model and RNA-sequencing on animal model.

Results: Quantitative detection of RNA methylation showed that H. pylori infection group had higher m6A modification level. M6A methylation sequencing identified 2,107 significantly changed m6A methylation peaks, including 1,565 upregulated peaks and 542 downregulated peaks. A total of 2,487 mRNA was upregulated and 1,029 mRNA was downregulated. According to the comprehensive analysis of MeRIP-seq and RNA-seq, we identified 200 hypermethylation and upregulation, 129 hypermethylation but downregulation, 19 hypomethylation and downregulation and 106 hypomethylation but upregulation genes. The GO and KEGG pathway analysis of these differential methylation and regulatory genes revealed a wide range of biological functions. Moreover, combining with mice RNA-seq results, qRT- PCR showed that m6A regulators, METTL3, WTAP, FTO and ALKBH5, has significant difference; Two key genes, PTPN14 and ADAMTS1, had significant difference by qRT- PCR.

Conclusion: These findings provide a basis for further investigation of the role of m6A methylation modification in H. pylori-associated gastritis.
Potential interaction between the oral microbiota and COVID-19: a meta-analysis and bioinformatics prediction
Authors: Tan Li , Zhong Meng-Mei , Liu Qiong , Chen Yun , Zhao Ya-Qiong , Zhao Jie , Dusenge Marie Aimee , Feng Yao , Ye Qin , Hu Jing , Ou-Yang Ze-Yue , Zhou Ying-Hui , Guo Yue , Feng Yun-Zhi
Published: June 2023

Objectives

The purpose of this study was to evaluate available evidence on the association between the human oral microbiota and coronavirus disease 2019 (COVID-19) and summarize relevant data obtained during the pandemic.

Methods

We searched EMBASE, PubMed, and the Cochrane Library for human studies published up to October 2022. The main outcomes of the study were the differences in the diversity (α and β) and composition of the oral microbiota at the phylum and genus levels between patients with laboratory-confirmed SARS-CoV-2 infection (CPs) and healthy controls (HCs). We used the Human Protein Atlas (HPA), Gene Expression Profiling Interactive Analysis (GEPIA) database, Protein−protein interaction (PPI) network (STRING) and Gene enrichment analysis (Metascape) to evaluate the expression of dipeptidyl peptidase 4 (DPP4) (which is the cell receptor of SARS CoV-2) in oral tissues and evaluate its correlation with viral genes or changes in the oral microbiota.

Results

Out of 706 studies, a meta-analysis of 9 studies revealed a significantly lower alpha diversity (Shannon index) in CPs than in HCs (standardized mean difference (SMD): -0.53, 95% confidence intervals (95% CI): -0.97 to -0.09). Subgroup meta-analysis revealed a significantly lower alpha diversity (Shannon index) in older than younger individuals (SMD: -0.54, 95% CI: -0.86 to -0.23/SMD: -0.52, 95% CI: -1.18 to 0.14). At the genus level, the most significant changes were in Streptococcus and Neisseria, which had abundances that were significantly higher and lower in CPs than in HCs based on data obtained from six out of eleven and five out of eleven studies, respectively. DPP4 mRNA expression in the oral salivary gland was significantly lower in elderly individuals than in young individuals. Spearman correlation analysis showed that DPP4 expression was negatively correlated with the expression of viral genes. Gene enrichment analysis showed that DPP4-associated proteins were mainly enriched in biological processes, such as regulation of receptor-mediated endocytosis of viruses by host cells and bacterial invasion of epithelial cells.

Conclusion

The oral microbial composition in COVID-19 patients was significantly different from that in healthy individuals, especially among elderly individuals. DPP4 may be related to viral infection and dysbiosis of the oral microbiome in elderly individuals.
Myocardial capacity of mitochondrial oxidative phosphorylation in response to prolonged electromagnetic stress
Authors: Savchenko Lesia , Martinelli Ilenia , Marsal Dimitri , Zhdan Vyacheslav , Tao Junwu , Kunduzova Oksana
Published: June 2023

Introduction

Mitochondria are central energy generators for the heart, producing adenosine triphosphate (ATP) through the oxidative phosphorylation (OXPHOS) system. However, mitochondria also guide critical cell decisions and responses to the environmental stressors.

Methods

This study evaluated whether prolonged electromagnetic stress affects the mitochondrial OXPHOS system and structural modifications of the myocardium. To induce prolonged electromagnetic stress, mice were exposed to 915 MHz electromagnetic fields (EMFs) for 28 days.

Results

Analysis of mitochondrial OXPHOS capacity in EMF-exposed mice pointed to a significant increase in cardiac protein expression of the Complex I, II, III and IV subunits, while expression level of α-subunit of ATP synthase (Complex V) was stable among groups. Furthermore, measurement of respiratory function in isolated cardiac mitochondria using the Seahorse XF24 analyzer demonstrated that prolonged electromagnetic stress modifies the mitochondrial respiratory capacity. However, the plasma level of malondialdehyde, an indicator of oxidative stress, and myocardial expression of mitochondria-resident antioxidant enzyme superoxide dismutase 2 remained unchanged in EMF-exposed mice as compared to controls. At the structural and functional state of left ventricles, no abnormalities were identified in the heart of mice subjected to electromagnetic stress.

Discussion

Taken together, these data suggest that prolonged exposure to EMFs could affect mitochondrial oxidative metabolism through modulating cardiac OXPHOS system.
Experimental evidence for the hydrothermal formation of native sulfur by synproportionation
Authors: Kürzinger Victoria , Hansen Christian T. , Strauss Harald , Wu Shijun , Bach Wolfgang
Published: June 2023

Elemental sulfur (S0) is known to form in submarine acid-sulfate vents by disproportionation of magmatic SO2. S0 formed upon disproportionation shows δ34SS values considerably lower than the influxing magmatic SO2, which results in δ34SS values typically <0‰. The peculiar occurrence of isotopically heavy sulfur in the Kemp Caldera hydrothermal system (δ34SS > 5‰) and Niua North (δ34SS = 3.1‰) led to the suggestion that disproportionation is not the only sulfur forming process in submarine hydrothermal systems. We conducted hydrothermal experiments to investigate if synproportionation of SO2 and H2S can explain the occurrence and isotopic composition of S0 observed in some vent fields. Provided that SO2 and H2S are both abundant, this formation mechanism is thermodynamically conceivable, but it has not yet been demonstrated experimentally that this process actually takes place in submarine hydrothermal systems. We conducted the experiments in collapsible Ti-cells under pT-conditions (20–30 MPa, 220°C) that are relevant to S0 formation in submarine hydrothermal systems. We used starting concentrations of 10 mM sulfite and 20 mM sulfide of known isotopic composition. Under acidic conditions (pH25 °C = 1.2), S0 was the most abundant reaction product, but small amounts of sulfate were also produced. A Rayleigh fractionation model was applied to determine the isotopic composition of SO42–, SO2, H2S and S0 expected to form by SO2 disproportionation, H2S oxidation, and SO2–H2S synproportionation. The sulfur isotopic signatures of the sulfur produced in the experiments can only be explained by synproportionation of sulfite and sulfide. These results provide strong evidence that synproportionation is likely responsible for exceptionally high δ34SS values observed in S0 from some arc/back-arc hydrothermal environments, like the Kemp Caldera in the South Sandwich arc. Coeval degassing of H2S and SO2 is likely required to have this particular reaction dominate in the H–S–O reaction network and produce noticeable accumulations of isotopically heavy native sulfur at the seafloor.
Decomposition of airflow over topography and its application to a topographic blizzard event in central Asia
Authors: Ma Shuping , Cai Ren , Ran Lingkun , Jiao Baofeng , Zhou Kuo , Guo Anboyu
Published: June 2023

To better understand the triggering mechanisms of extreme precipitation events in Central Asia due to the complex terrain, a case study of a topographic blizzard that occurred in Xinjiang Province on 30 November 2018 is conducted. The near-surface wind field is decomposed into flow-around and flow-over components to analyze the dynamic and thermodynamic effects of the flow around and over the topography in the Ili River valley and the northern slope of the Tianshan Mountains. The results reveal that the flow around the topography is the dominant component of the flow field that transports water vapor and causes moisture convergence. The symmetric instability observed at the lower level of the snowfall area is attributed to the flow-around wind field, which leads to advective transport of generalized potential temperature and causes changes in potential vorticity, ultimately resulting in symmetric instability. The local variation of stratified instability in the snowfall area is caused by flow-over potential divergence, specifically, the advection of the flow-over wind vertical shear to equivalent potential temperature causes the change of flow-over potential divergence, thus promotes stratified instability. Moreover, the flow-over potential divergence is negatively correlated with the amount of topographic snowfall to a certain extent, which can provide reference for topographic snowfall forecast in the future. Additionally, the cyclonic vorticity in the snowfall area is mainly caused by the flow around topography and flow-around wind produces favorable vortical circulation conditions for snowfall, while the vertical movement near the ground at the snowfall triggering stage is mainly caused by the flow-over component. Furthermore, the flow-over kinetic energy in the snow area is stronger and the work done by the pressure gradient force caused by flow over terrain drives kinetic energy changes.
Mating modifies the expression of crucial oxidative-reductive transcripts in the pig oviductal sperm reservoir: is the female ensuring sperm survival?
Authors: Álvarez-Rodríguez Manuel , Roca Jordi , Martínez Emilio A. , Rodríguez-Martínez Heriberto
Published: June 2023

Background

Mating induces large changes in the female genital tract, warranting female homeostasis and immune preparation for pregnancy, including the preservation of crucial oxidative status among its pathways. Being highly susceptible to oxidative stress, sperm survival and preserved function depend on the seminal plasma, a protection that is removed during sperm handling but also after mating when spermatozoa enter the oviduct. Therefore, it is pertinent to consider that the female sperm reservoir takes up this protection, providing a suitable environment for sperm viability. These aspects have not been explored despite the increasing strategies in modulating the female status through diet control and nutritional supplementation.

Aims

To test the hypothesis that mating modifies the expression of crucial oxidative-reductive transcripts across the entire pig female genital tract (cervix to infundibulum) and, particularly in the sperm reservoir at the utero-tubal junction, before ovulation, a period dominated by estrogen stimulation of ovarian as well as of seminal origin.

Methods

The differential expression of estrogen (ER) and progesterone (PR) receptors and of 59 oxidative-reductive transcripts were studied using a species-specific microarray platform, in specific segments of the peri-ovulatory sow reproductive tract in response to mating.

Results

Mating induced changes along the entire tract, with a conspicuous downregulation of both ER and PR and an upregulation of superoxide dismutase 1 (SOD1), glutaredoxin (GLRX3), and peroxiredoxin 1 and 3 (PRDX1, PRDX3), among other NADH Dehydrogenase Ubiquinone Flavoproteins, in the distal uterus segment. These changes perhaps helped prevent oxidative stress in the area adjacent to the sperm reservoir at the utero-tubal junction. Concomitantly, there were a downregulation of catalase (CAT) and NADH dehydrogenase (ubiquinone) oxidoreductases 1 beta subcomplex, subunit 1 (NDUFB1) in the utero-tubal junction alongside an overall downregulation of CAT, SOD1, and PRDX3 in the ampullar and infundibulum segments.

Conclusions

Natural mating is an inducer of changes in the expression of female genes commanding antioxidant enzymes relevant for sperm survival during sperm transport, under predominant estrogen influence through the bloodstream and semen. The findings could contribute to the design of new therapeutics for the female to improve oxidative-reductive balance.