bluuebunny/crossref_metadata_2025 huggingface dataset:
Strategi Pengembangan Komoditi Paprika (Capsicum annuum L) Pada Kelompok Tani Sri Rejeki Di Kecamatan Cepogo Kabupaten Boyolali
Authors: Azizah Nurul , Kusnandar Kusnandar , Sundari Mei Tri
Published: February 2024

Paprika merupakan salah satu komoditi hortikultura yang berpotensi tinggi untuk dibudidayakan karena tingginya permintaan dalam negeri maupun internasional. Budidaya paprika di Kabupaten Boyolali hanya terdapat di Kecamatan Cepogo yang di kelola oleh Kelompok Tani Sri Rejeki. Paprika yang dihasilkan memiliki kualitas yang baik, namun produksinya sangat terbatas. Keterbatasan modal dan pemanfaatan sarana prasarana penunjang kegiatan pertanian yang belum optimal menjadi permasalahan yang dihadapi oleh Kelompok Tani Sri Rejeki. Tujuan penelitian ini adalah untuk mengidentifikasi faktor internal dan faktor eksternal serta merumuskan strategi pengembangan komoditi paprika pada Kelompok Tani Sri Rejeki. Merode yang digunakan dalam penenlitian ini adalah deskriptif analitis. Berdasarkan hasil analisis SWOT terdapat lima strategi yang dirumuskan yaitu : (1) Mempertahankan pasar yang sudah ada, (2) Mengoptimalkan sumber daya manusia yang sudah ada, (3) Optimasi produksi, (4) Meningkatkan kualitas produk, (5) Pemberian sanksi tegas bagi petani. Hasil penelitian juga menunjukkan bahwa adanya optimasi produksi menjadi prioritas alternatif strategi pengembangan komoditi paprika di Kecamatan Cepogo, Kabupaten Boyolali.
Peran Penyuluh Terhadap Partisipasi Petani Pada Program Pendampingan Kelompok Di Kecamatan Blora
Authors: Wahyudi Achmad Fahrul , Sumekar Wulan , Prasetyo Agus Subhan
Published: February 2024

This research aims to obtain information on the role of agricultural extension workers and farmers’ participation in group assistance programs and analyze the effect of agricultural extension workers on farmers’ participation in the group assistance program. The method used in this research is a survey method through purposive sampling by considering members of farmer groups still active in mentoring programs. Primary data collection used interviews and observation, while secondary data used documentation. This research used descriptive analysis and Multiple Linear Regression analysis with an   SPSS application. The results showed that 59 farmers (49%) assessed the role of agricultural extension workers in the moderate category, 37 farmers (31%) low category, and 24 farmers (20%) high category. The level of farmers’ participation in the group assistance program is in the moderate category. The role of the agricultural extension workers as an educator, facilitators, motivators, and evaluators partially had a significant effect on the involvement of farmers in group assistance programs in the Blora District. In contrast, as a communicator hadn’t a significant effect. The role of agricultural extension workers as an educator, facilitators, communicators, motivators, and evaluators significantly affected farmers’ participation in group assistance programs in Blora District.
Analisis Break Even Point (Bep) Usaha Pembibitan Semangka Di CV Nusantara Group Kecamatan Gunung Sugih, Kabupaten Lampung Tengah, Provinsi Lampung
Authors: Selvita Aggnes Listy , Listiyani Listiyani , Sayekti Agatha Ayiek Sih
Published: February 2024

The aims of the study: 1) to determine the growth in acceptance and profits of the watermelon nursery business in CV. Nusantara Group in 2019 - 2022; 2) to find out BEP (production BEP, price BEP, and acceptance BEP); 3) to determine the sensitivity value of production BEP and acceptance BEP to changes in prices and production costs. The basic research method used is descriptive method by collecting data compiled and analyzed. The location determination method uses purposive sampling by choosing a location deliberately based on the business that carries out watermelon nurseries. The data analysis used is quantitative analysis with break even point and profit data analysis methods. The results show that the highest revenue growth will occur in 2022 (41%), the highest profit growth will occur in 2021 (130%). The lowest production BEP occurred in 2021 (164.086 seeds), 2021 price BEP (Rp. 1.490/seed), 2021 revenue BEP (Rp. 278.946.844). The selling price sensitivity decreased (5%), the production BEP increased (17%) and revenue BEP increased (11%). While the sensitivity of production costs increased (5%), production BEP increased (16%) and revenue BEP increased (16%).
Konversi Lahan Pertanian Dan Dampaknya Terhadap Kesejahteraan Petani Dan Ketahanan Pangan Di Provinsi Bali
Authors: A.A.A I Made Sudarma , Sawitri Dj Wulandira , Bagus Dera Setiawan I Gede
Published: February 2024

Land conversion is a logical consequence of increasing activity and population as well as other development processes. Land conversion is a natural thing to happen, but in reality, land conversion is a problem because it occurs on agricultural land that is still productive. The purpose of this study was to determine the factors that influence the conversion of agricultural land; know the impact of conversion of agricultural land on the welfare of farmers; and understanding the impact of the conversion on food security. Data analysis used in this study was factor analysis using a computer with the SPSS 19.0 program package. Based on the results of the research, the conclusion that can be drawn from this research is that the main factors driving land conversion are external and internal. The dominant external factors driving conversion are increased land requirements, more promising jobs in other sectors, uncertainty in the price of agricultural products (price fluctuations), and difficulties in finding workers in the agricultural sector. Internal factors driving land conversion are difficulties in obtaining water resources, high risk, and economic pressure; there was an increase in the income of Subak Gadon farmers on an average of IDR 240,650/are/month as a result of farmers converting land from paddy fields to utilization for business ventures. Land conversion does not affect the food security of farming families but affects food supply at the regional level.
Topical issues of legalization of unauthorized alterations and alterations of residential premises
Authors:   Yulia I. Khailova Kuban State AgrarianUniversity named after I. T. Trubilin, Khailova Yulia I. , Maslennikova Lyudmila V. ,   Lyudmila V. Maslennikova Kuban State AgrarianUniversity named after I. T. Trubilin
Published: February 2024

В настоящее время обострилась проблема правовой регламентация отношений, связанных с переустройством, перепланировкой жилого помещения. Значимость данной темы обусловлена тем, что большое количество граждан обращается в судебные органы с исковыми заявлениями, такими как: о сохранении перепланировки квартиры, о сохранении жилого помещения в перепланированном состоянии, о сохранении неправомерно произведенных перепланировок или переустройств. Именно поэтому в данной статье обсуждаются актуальные проблемы, связанные с легализацией самовольных переустройств и перепланировок жилых помещений. Анализируется действующее законодательство, связанное с процедурой узаконивания, приводятся различные мнения ученых о правовом регулировании переустройства и перепланировок жилых помещений, рассматривается практика применения правовых норм и выявляются основные проблемы, с которыми сталкиваются собственники жилых помещений в вопросах темы научного исследования.
The use of IT-technologies in the commission of crimes is a global problem of the state
Authors:   Olga S. Polikarpova St. Petersburg University of the Ministry of Internal Affairs of Russia, Polikarpova Olga S.
Published: February 2024

В статье рассматривается проблема, порождаемая внедрением информационных и телекоммуникационных технологий в совершение общественно опасных деяний, как входящих в группу преступлений, отнесенных к компьютерной информации, так и выходящих за ее пределы, актуальность которой обусловлена стремительным ростом преступлений, совершаемых посредством применения информационных технологий и сети «Интернет». Отмечены принятые на государственном уровне нормативные правовые акты, направленные на защиту информации, регулирование отношений, связанных с выпуском и оборотом цифровых финансовых активов, внедренных в повседневную жизнь современного общества вследствие развития информационных технологий, в том числе обусловленные дополнением Уголовного закона Российской Федерации новыми квалифицированными признаками составов хищений, позволяющих расширить круг лиц, в действиях которых усматриваются признаки преступлений, совершаемых с применением таких технологий. Положительно отмечен и вклад научного сообщества в разработку пособий и рекомендаций, направленных на противостояние киберпреступности. По результатам исследования указано на необходимость внесения изменений в главу 14 Уголовно-процессуального кодекса Российской Федерации и разработку методических рекомендаций, направленных на разъяснение порядка наложения ареста на имущество, что может быть реализовано лишь в результате признания имуществом цифровых финансовых активов, включая криптовалюты.
HUMAN RIGHTS AND FREEDOMS AS A BASIS FOR SUSTAINABLE DEVELOPMENT OF SOCIETY AND THE STATE
Authors:   Vasilevich D.GR. International University ", Vasilevich D.GR. ,   MITSO",   .
Published: February 2024

В статье освещаются вопросы юридического закрепления прав и свобод граждан. Проводится различие в оценках прав и свобод в условиях острого политического противостояния. Подчеркивается, что в нынешних условиях в западных странах подаются уже иные примеры отношения к свободе слова, охране права собственности, равенству всех независимо от национальной принадлежности. Эти ранее проповедуемые ценности сейчас не являются абсолютными категориями. Акцентировано внимание на расширении института правового статуса человека и гражданина за счет появления новых групп прав – информационных и соматических. Предлагается на международном уровне регламентировать отношения по поводу использования сети Интернет посредством принятия международного пакта. Подчеркнуто, что значительный мировоззренческий конфликт возникает по поводу соматических прав. Отстаивается идея важности сохранения традиционных семейных, исторических и культурных ценностей российского многонационального государства.
The constitutional status of the individual in the light of constitutional reforms
Authors:   Ravzanat A. Nimatulayeva Dagestan State University, Nimatulayeva Ravzanat A.
Published: February 2024

В статье рассматривается вопрос о конституционном статусе личности в свете конституционной реформы 2020 г., целью которой является обновление конституционного статуса личности, закрепление новых прав, свобод, гарантий их реализации, а также новых обязанностей личности. Говорится, что изучение специфики основ конституционного статуса личности является одним из актуальных вопросов конституционного права. Раскрывается значение конституционных изменений, их влияние на конституционный статус личности, права и свободы человека и гражданина. Дается определение конституционного статуса личности. Перечисляются элементы конституционного статуса личности. Характеризуются принципы конституционного статуса личности как основополагающие начала, лежащие в основе осуществления прав, свобод и обязанностей человека и гражданина. Основным выводом является положение, согласно которому конституционный статус личности в России нуждается в модернизации, связанной, прежде всего, с усилением гарантий реализации и защиты прав и свобод личности.
Child safety as a constitutional value
Authors:   Tamila M. Nintsieva Chechen State University, Nintsieva Tamila M.
Published: February 2024

Конституция Российской Федерации, являясь основным законом Российской Федерации, включающим в себя основополагающие постулаты жизнедеятельности государства и общества, выступает гарантом защиты и соблюдения прав и свобод человека и гражданина. Конституционные ценности формируют государство и общество, на их основе проводится правовой и исторический анализ внутренней и внешней политики государства, что актуализирует необходимость их изучения и анализа. В этой связи немаловажно, что ребенок, являясь лицом недееспособным, становится заложником государственной системы и конституционных ценностей, регулирующих общественные отношения в области защиты детей. В данной статье проводится анализ норм Конституции Российской Федерации, отражающие степень заинтересованности государства в безопасности детей. Для более точного анализа конституционных норм в указанной области, приводятся законодательные и иные нормативные правовые акты Российской Федерации, регулирующие вопросы безопасности детей. А также отмечается значимость безопасности ребенка как конституционной ценности Российской Федерации.
Administrative and legal aspects of state control in the sanitary and epidemiological sphere
Authors:   Julia S. Goloborodko Rostov State University of Economics ", Goloborodko Julia S. ,   RINH"
Published: February 2024

В статье рассматриваются проблемы государственного регулирования санитарно-эпидемиологических отношений, анализируются административные акты и процедуры в области защиты здоровья и санитарного благополучия граждан, в том числе в условиях пандемии. Анализируются теоретические подходы государственного контроля и надзора в санитарно-эпидемиологической сфере, затрагиваются вопросы административной ответственности за нарушения в данной области.
Features of the administrative and legal status of foreign agents in the Russian Federation
Authors:   Renat L. Miftakhov Kazan branch of the Russian State University of Justice, Miftakhov Renat L. , Belousov Artem I. ,   Artem I. Belousov Kazan branch of the Russian State University of Justice
Published: February 2024

Вхождение освобожденных территорий Донецкой и Луганской Народных республик, Херсонской и Запорожской областей (далее – новые субъекты РФ) в состав Российской Федерации в условиях проведения специальной военной операции по демилитаризации и денацификации Украины вызывает необходимость административного интегрирования в правовое пространство и административного обеспечения национальной безопасности этих территорий. Цель исследования заключается в проведении комплексного анализа теоретико-правовых основ системы административно-правового обеспечения национальной безопасности на освобожденных территориях. Методологическую основу научной статьи составляют общенаучные методы (диалектический, системный, исторический) и частные (формально-логический, функциональный) методы исследования. Понятие «национальная безопасность» нормативно закреплено в Указе Президента Российской Федерации от 2 июля 2021 года № 400 «О Стратегии национальной безопасности» и определяется как состояние защищенности национальных интересов Российской Федерации от внешних и внутренних угроз, при котором обеспечивается реализация конституционных прав и свобод граждан, достойное качество жизни и уровень их жизни, гражданский мир и согласие в стране, охрана суверенитета Российской Федерации, её независимости и государственной целостности, социально-экономическое развитие страны. Необходимо отметить, что в свою очередь угроза национальной безопасности представляет собой совокупность условий и факторов, создающих прямую или косвенную возможность нанесения ущерба национальным интересам Российской Федерации.
Problems of implementation and observance of the principle of non-use of force or threat of force
Authors:   Madina N. Alieva Dagestan State University, Alieva Madina N. , Khizriev Ruslan M. ,   Ruslan M. Khizriev Dagestan State University
Published: February 2024

В статье затрагивается проблема реализации принципа неприменения силы или угрозы силой как одного из основных в системе международного права. Доказано, что несоблюдение данного принципа влечет нарушение остальных принципов международного правопорядка, т.н. jus cogens. Подчеркивается, что определение агрессии согласно Резолюции 3314 (ХХIХ) Генеральной Ассамблеи ООН от 14 декабря 1974 года не охватывает всех действий государств, провоцирующих применение силовых мер. Анализируется роль Совета Безопасности ООН, уполномоченного выявлять существующие международные угрозы и принимать соответствующие решения для поддержания мира и безопасности, а также приводится практика применения вооруженной силы рядом государств, осуществляемая без санкции на то Совета Безопасности ООН. Подтверждается обоснованность предложений по реформированию организационной структуры ООН, что должно привести к преобразованию процедуры формирования Совета Безопасности ООН с целью повышения эффективности механизма разрешения международных конфликтов. Особое внимание уделяется концепции «ответственности по защите», которая в последнее время применяется избирательно. Высказываются различные предложения по повышению эффективности механизма реализации принципа неприменения силы или угрозы силой. Делается вывод о том, что существование международных институций и системы ограничительных норм не могут сегодня гарантировать исполнение государствами требований международного права.
Periodicals and the History of their Present: Die Zeiten (1805–20) as Chronopoetic Historiography
Authors: Ramtke Nora
Published: February 2024

This article discusses periodicals as media forms that are dependent on and correlated with time. It treats periodical publication as a form of chronopoetics, exploring modes of writing the present at work in journals as well as their varied relationships to writing history. Focusing on Die Zeiten (1805–20), a German-language historio-political monthly journal of the Napoleonic Era, the article describes chronopoetic writing as the layering of history; the experience of time in and through medial formats, and the more specific rhetorical, material, and medial temporalities of periodicals.
Review of Marysa Demoor, Cedric Van Dijck, and Birgit Van Puymbroeck, eds, The Edinburgh Companion to First World War Periodicals (2023)
Authors: Einhaus Ann-Marie
Published: February 2024

Review of Marysa Demoor, Cedric Van Dijck, and Birgit Van Puymbroeck, eds, The Edinburgh Companion to First World War Periodicals (2023)
Arts in Health in Nederland: Een nationale agenda
Authors: Lewis Ferdinand , Krans Kirsten
Published: February 2024

Arts in health verwijst naar het veld dat artistieke en creatieve praktijken toepast om gezondheid en welzijn te bevorderen en een positieve benadering van gezondheid te stimuleren. Terwijl arts in health internationaal al decennialang een gevestigd veld is in andere landen, is het Nederlandse veld nog steeds gefragmenteerd en blijft het groeiende potentieel ervan onderbenut. Deze whitepaper is een intersectorale verkenning van de huidige stand van zaken op het gebied van arts in health in Nederland. De auteurs zijn ervan overtuigd dat arts in health kan helpen om de grote uitdagingen waar onze gezondheidszorg de komende decennia voor staat, het hoofd te bieden en hebben een agenda geformuleerd voor het verduurzamen van het veld voor arts in health in Nederland.
Forecasting Hospital Room and Ward Occupancy Using Static and Dynamic Information Concurrently: Retrospective Single-Center Cohort Study
Authors: Seo Hyeram , Ahn Imjin , Gwon Hansle , Kang Heejun , Kim Yunha , Choi Heejung , Kim Minkyoung , Han Jiye , Kee Gaeun , Park Seohyun , Ko Soyoung , Jung HyoJe , Kim Byeolhee , Oh Jungsik , Jun Tae Joon , Kim Young-Hak
Published: February 2024

Background

Predicting the bed occupancy rate (BOR) is essential for efficient hospital resource management, long-term budget planning, and patient care planning. Although macro-level BOR prediction for the entire hospital is crucial, predicting occupancy at a detailed level, such as specific wards and rooms, is more practical and useful for hospital scheduling.

Objective

The aim of this study was to develop a web-based support tool that allows hospital administrators to grasp the BOR for each ward and room according to different time periods.

Methods

We trained time-series models based on long short-term memory (LSTM) using individual bed data aggregated hourly each day to predict the BOR for each ward and room in the hospital. Ward training involved 2 models with 7- and 30-day time windows, and room training involved models with 3- and 7-day time windows for shorter-term planning. To further improve prediction performance, we added 2 models trained by concatenating dynamic data with static data representing room-specific details.

Results

We confirmed the results of a total of 12 models using bidirectional long short-term memory (Bi-LSTM) and LSTM, and the model based on Bi-LSTM showed better performance. The ward-level prediction model had a mean absolute error (MAE) of 0.067, mean square error (MSE) of 0.009, root mean square error (RMSE) of 0.094, and R2 score of 0.544. Among the room-level prediction models, the model that combined static data exhibited superior performance, with a MAE of 0.129, MSE of 0.050, RMSE of 0.227, and R2 score of 0.600. Model results can be displayed on an electronic dashboard for easy access via the web.

Conclusions

We have proposed predictive BOR models for individual wards and rooms that demonstrate high performance. The results can be visualized through a web-based dashboard, aiding hospital administrators in bed operation planning. This contributes to resource optimization and the reduction of hospital resource use.
Effectiveness evaluation of antibiotic use in patients with Methicillin-resistant Staphylococcus aureus (MRSA) infection: a review
Authors: As Musdalifa , Ika Puspitasari  , Nuryastuti Titik
Published: February 2024

Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogen that become a public health problem due to its ability to be resistant to more than three classes of antibiotics. Evaluation of the effectiveness of antibiotic use in patients with MRSA is important to optimize antibiotic use and to control antibiotic resistance. This article review attempted to evaluate the effectiveness of antibiotics in patients with MRSA. This review explored the results of previous research from PubMed as a literature source and the PRISMA flow diagram as a protocol for the article selection process. Eight studies reviewed the evaluation of the effectiveness of antibiotic use in MRSA patients with various clinical conditions, such as uncomplicated wound infections, cellulitis and no wound, purulent drainage or abscess, cSSSI infections caused by MRSA, infections caused by MRSA bacteremia and nosocomial infections caused by MRSA. In conclusion, the effectiveness of antibiotics in patients with MRSA infection depends on the clinical condition of each patient. Therefore, the use of antibiotics is adjusted based on the type of infection and the efficacy of the antibiotics. Combination therapy is recommended for MRSA patients considering its life-threatening ability.
Efficacy and safety of clozapine combination with different antipsychotics in schizophrenia: a systematic review
Authors: Maria Sri Ayu Mustikawati  , Bambang Hastha Yoga Legowo Budiman  , Zullies Ikawati
Published: February 2024

Schizophrenia is a severe and chronic mental disorder, where antipsychotics are used as the main therapy. Antipsychotics are commonly used in combination, especially in refractory patients. Clozapine is one of antipsychotics that is often used in combination with other antipsychotic to achieve more effective treatment. However, the effectiveness and safety of the clozapine combination are still inconclusive. This review aimed to evaluate the efficacy and safety evidence of clozapine combination therapy with different other antipsychotics. Relevant articles were collected from Google Scholar, Scopus, and PubMed, and published in 2000-2020. Five studies concerning the effectiveness and safety of clozapine in combination with different other antipsychotics were evaluated. No significant difference in the effectiveness of clozapine in combination with other antipsychotics was observed in 4 studies. No significant difference in the safety of all clozapine combinations was observed in 3 studies. Only 2 studies reported that the clozapine-atypical antipsychotic combination (clozapine-aripiprazole) is more tolerable compared to the clozapine-typical antipsychotic. In conclusion, the efficacy and safety of clozapine in combination with different other antipsychotics have not been definitively conclusive, yet.
MICROENCAPSULATION BISOPROLOL FUMARATE WITH EUDRAGIT E PO BY SOLVENT EVAPORATION METHOD
Authors: GUMALA AZHOMA , FEBRIYENTI  , ARMIN FITHRIANI , YULINDRA ZAHRAH
Published: February 2024

Objective: This study aimed to develop and optimize the microcapsule formula of bisoprolol fumarate-Eudragit EPO by double-emulsion solvent evaporation.

Methods: The preparation of bisoprolol fumarate-Eudragit EPO microcapsule was done in three different ratios 1: 3 (F1), 1: 4 (F2), and 1: 5 (F3), followed by characterization of each of the microcapsule formula using Fourier transform infrared, scanning electron microscopy, particle size analyzer. Further analysis included investigation of the drug loading, entrapment efficiency, solubility in pH 6.8, and the difference among dissolution profiles of each microcapsule using one-way ANOVA.

Results: Infra-red spectrum showed no chemical interaction between bisoprolol fumarate and Eudragit E PO in microcapsules. The morphology and structure of F1 microcapsule was irregular spheres, while F2 and F3 were regular spheres. The average particle distribution of microcapsules was 24.765±0,236 μm (F1), 28.245±0,252 μm (F2), and 40.634±0,218 μm (F3). The drug loading was 7.691±0,087 % (F1), 8.922±0,056 % (F2), and 9.012±0,133% (F3). The encapsulation efficiency was 4.980 % (F1), 5.857%(F2), and 6,285 %(F3). The average amount of bisoprolol fumarate released in pH 6.8 was 2.113±0,289 % (F1), 1.954±0,015 % (F2), and 1.619±0,020 % (F3). The dissolution profile between each formula was statistically different (p value= 0,000).

Conclusion: As the low value of drug loading and encapsulation efficiency in each formula, we concluded that the microencapsulation formula with Eudragit EPO by solvent evaporation method is not effective to entrap bisoprolol fumarate.
CYTOTOXIC ACTIVITY OF TAXUS SUMATRANA (MIQ.) DE LAUB. BARK, LEAVES, AND SHOOTS ON HELA, T47D, AND MCF-7/HER2 CELL LINES
Authors: WAHYUNI FATMA SRI , PUTRI DESI EKA , PUTRA YOZARWARDI USAMA , HAMIDI DACHRIYANUS
Published: February 2024

Objective: Taxus sumatrana (Miq.) de Laub. (cemara Sumatra) is one of the plants found in Indonesia and other countries known as a medicine plant. Taxus's bark, leaves, and shoots are used traditionally and massively for some diseases (cancer, etc.), so recently it has become a rare plant. The chemical constituents of T. sumatrana are alkaloids, steroids, tannins, and flavonoids. This study aimed to investigate the potential anticancer properties of T. sumatrana bark, leaves, and shoot extracts.

Methods: The cytotoxic activity against the HELA, T47D, and MCF-7/HER2 cell lines was determined using the MTT assay. Each cell was cultured on 96 well plates treated with extract of T. sumatrana with concentrations of 100, 10, 1, and 0,1 µg/ml. Cells were incubated for 48 h at 37 °C, 5% CO2 and then given 100 µl MTT solution 0.5 mg/ml in PBS (Phosphate Buffer Saline) for 4 h. The results of the measurements were processed with the GraphPad Prism Program.

Results: The bark, leaves, and shoots extracts have strong cytotoxic activity based on IC50 parameters. The mean IC50 of bark, leaves, and shoots on the HELA cell line consecutively 8.94; 5.93; and 4.08 μg/ml; on the T47D cell line 5.80, 4.86, and 4,11 μg/ml; and on MCF-7/HER2 cell line 7.46, 10.60, and 13.74 μg/ml).

Conclusion: T. sumatrana bark, leaves, and shoots have potential anti-cancer properties.
DEVELOPMENT AND VALIDATION OF A BIOANALYTICAL METHOD FOR THERAPEUTIC DRUG MONITORING OF AMIKACIN IN HUMAN PLASMA USING ULTRA-PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY
Authors: SENTAT TRISWANTO , LUCIDA HENNY , WIDYATI WIDYATI , NASIF HANSEN , HARAHAP YAHDIANA , HARIJONO PANDU , RATIH RATIH
Published: February 2024

Objective: The primary purposes of this research were to develop and validate a novel, accurate, sensitive, and repeatable bioanalytical method for determining amikacin in human plasma employing UPLC-MS/MS.

Methods: The bioanalytical procedure of amikacin involved a BEH C18 UPLC column as a stationary phase, with an employed mobile phase consisting of 0.1% v/v formic acid and acetonitrile (85:15 v/v). The flow rate was set at 0.1 ml/min, and the column temperature was kept at 30 °C. Kanamycin was selected as an internal standard. Amikacin and kanamycin were determined at mass-to-charge ratios (m/z) of 585.9>162.9 and 484.67>162.83, respectively. The amikacin bioanalysis method in the plasma matrix at the optimum separation condition was validated by determination of selectivity, linearity, accuracy, precision, recovery, carry-over, matrix effect, and stability.

Results: The optimum conditions of the sample preparation procedure were obtained through liquid-liquid extraction using trichloroacetic acid, followed by vortex mixing for one minute and centrifugation at 10,000 rpm for five minutes. Ten µl of supernatant was collected and injected into the system. A linear response was achieved in the 1.0-150.0 µg/ml range with R2 0.9997. Accuracy and precision met the requirements with % differences and coefficient variation at all concentration levels less than 15% and at the LLOQ level (1 μg/ml) less than 20%. The validated analytical method of amikacin in plasma is required for therapeutic monitoring in patients. The data would be valuable for determining or adjusting amikacin doses to enhance patient safety.

Conclusion: A bioanalytical method was developed and validated for determining amikacin in human plasma by UPLC-MS/MS. The method selectivity, linearity, accuracy, precision, recovery, carry-over, matrix effect, and stability were performed.
Fitting Power-Law Relations in Watershed Science and Analysis, with an Example Using the R Language
Authors: Moore R. Dan
Published: February 2024

Many quantitative relationships in the environmental sciences, and specifically in watershed science, can effectively be modelled using a power-law function. Such relationships are often estimated using ordinary least squares regression after linearizing the relationship by log-transforming both the x and y variables. Alternative approaches include nonlinear least squares regression and generalized nonlinear least squares regression. However, there are some differences in the underlying characteristics of  these models that can result in the generation of different relationships and associated prediction limits. This article provides an overview of the statistical models underlying these approaches, then illustrates their application using the R language for an example based on fitting a regional relationship to predict flood quantiles from catchment area.
Keywords: law relationships, log-transformation, nonlinear least squares regression, generalized nonlinear least squares regression
Health Behaviors and Mental Health of Adolescents in Relation to Their Mukbang(Eating Show) Watching -Utilizing the 18th Annual Youth Health Behavior Survey of 2022
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Wi Ok Youn , Lee Ji Hyun
Published: February 2024

Objectives This research seeks to investigate the health behaviors and mental health of adolescents in relation to their level of engagement in mukbang(eating show) watching. The objective is to offer fundamental data for the improvement of adolescent health behaviors and mental health.
Methods This secondary analysis study utilized raw data obtained from the 18th Annual Youth Health Behavior Survey of 2022. The analysis involved using the SPSS/WIN 20 program to conduct complex sample frequency analysis, complex sample cross-tabulation, and complex sample logistic regression.
Results First, daily viewership of mukbang was observed among female students attending girls' schools, as well as adolescents with lower academic performance, lower economic status, and parents with lower educational levels. Second, in terms of dietary habits, adolescents who did not watch mukbang at all had a higher intake of breakfast(1.48 times) and fruits(1.38 times) compared to those who watched it every day. Furthermore, they con-sumed fewer sweetened beverages(0.73 times), fast food(0.66 times), and late-night snacks(0.71 times). Third, in terms of physical activity, adolescents who watched mukbang occasionally engaged in higher levels of high-in-tensity physical activity(1.10 times), moderate-intensity physical activity(1.21 times), and walks lasting 10 mi-nutes or more(1.39 times) compared to those who watched it daily. Fourth, in terms of mental health, adolescents who never watched mukbang exhibited lower levels of loneliness(0.59 times), stress(0.64 times), feelings of sad-ness and despair(0.51 times), suicidal ideation(0.64 times), suicide planning(0.60 times), and suicide at-tempts(0.50 times) compared to those who watched it daily.
Conclusions The effects on the health behaviors and mental health of adolescents appear to vary based on the levels of mukbang watching. Consequently, it is essential to develop and implement phased mukbang media edu-cation programs and parental intervention programs.
Study of Fathering as seen through Yak-yong Jeong’s Child-rearing Attitudes: Focused on His Letters from Exile
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Park Hye-sook , Jung Min-ja
Published: February 2024

Objectives This study presented a desirable model of fathering for fathers in this era to contemplate on child-rear-ing by sincere fathers and analyzed fathering as seen through the child-rearing attitudes of Yak-yong Jeong in the Joseon Dynasty to facilitate their growth as fathers.
Methods Given that Yak-yong Jeong is no longer alive, this study employed the content analysis method through literature. Content analysis refers to all documented materials that have been accumulated from the past and exist in the present, related to the research topic, and it is a research method that analyzes already produced materials. Literature includes personal documents that record individuals’ lives, such as diaries, letters, memoirs, or autobiographies.
Results This study categorizes fathering into six elements. First, despite physical separation, Jeong conveyed his presence to his children through letters, serving as their caregiver, protector, and guide. He also supported their livelihood by sharing helpful farming methods and promoted family unity for the prosperity of his lineage. As a no-bleman, he directed his family's scholarly advancement. Additionally, he acted as a mentor, encouraging his child-ren's insights and reflections while experiencing personal growth through his own writing activities.
Conclusions In today's context, the significance of fathers as co-nurturers is highlighted. Instead of imitating ideal fathering shaped by rapidly changing societies, fathers should establish the foundations of authentic fathering and develop a personal identity to practice it effectively.
The relationship between pre-service teachers’ perspective-taking and multicultural behavior: The mediating effects of prejudice and multicultural attitudes
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Rim Dasol , Kim Young Hwa
Published: February 2024

Objectives This study explored the mediating effects of prejudice and multicultural attitudes in the relationship between perspective-taking and multicultural behavior among pre-service teachers.
Methods Two hundred and twenty-four pre-service teachers from single-Korean-ethnic background participated in the surveys assessing perspective-taking, prejudice, multicultural attitude, multicultural behavior, and demo-graphic characteristics.
Results The results found that perspective-taking and multicultural attitude had a positive correlation with multi-cultural behavior. On the other hand, prejudice was negatively correlated with multicultural behavior. Also, preju-dice and multicultural attitudes showed a mediating effect in the relationship between perspective-taking and multicultural behavior. In the relationship between perspective-taking and multicultural behavior, the indirect ef-fect of prejudice was not found, but the indirect effect of multicultural attitude was significant. In addition, the path from perspective-taking to multicultural behavior by sequentially mediating prejudice and multicultural attitude was significant.
Conclusions These results suggested that prejudice and multicultural attitudes may play an important role in the relationship between perspective-taking and multicultural behavior. Accordingly, this study discussed educa-tional intervention through perspective-taking to promote multicultural behavior of prospective teachers. Finally, limitations of the study and suggestions for future research were discussed.
Analysis of University Student’s Dropout Intention: Effects of Tinto’s Student Integration, Student Characteristics, and University characteristics
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Heeran , Mo Hwasook
Published: February 2024

Objectives The purpose of this study is to explore differences between first and second year of college students' dropout intention related to university characteristics, student characteristics, and students' social and economic conditions, along with Tinto's student integration factor.
Methods The National Assessment of Student Engagement in Learning data collected by the Korean Educational Development Institute(KEDI) in 2021 were used. The number of participants were 28,353 students of four-year universities. A logistic regression analysis was conducted.
Results First-year students attending universities non-metropolitan area had a higher intention to dropout, but second-year students attending universities small size in the metropolitan area also did. Dropout intention was lower when first-year students were in the medication field, and for second-year students when they were in the social sciences, engineering, medicine, or arts and physical sciences fields, compared to those in the humanities. For both year students, when active or collaborative learning and self-evaluation of basic learning abilities was high, the dropout intention was low. Additionally, the first-year students, extracurricular activities and high inter-action with peers lowered the dropout intention.
Conclusions Dropout intention differs depending on the first and second year of university, and based on the re-sults, the need for financial and administrative policy support from individuals, universities, and educational au-thorities to prevent dropout and equal educational opportunities
Satisfaction and Improvement Demands for EBS High School Lectures
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Park Hyerang , Kim Hyunchul
Published: February 2024

Objectives The purpose of this study was to investigate the satisfaction level and improvement needs for EBS high school lectures.
Methods Stratified cluster sampling design using province as a stratum and school as a cluster was used to extract 1,320 student samples and 404 teacher samples nationwide. EBS high school lectures were categorized into vid-eo and textbooks, and differences in responses were tested across six student and seven teacher demographic characteristics.
Results The results show that both students and teachers expressed high levels of satisfaction with EBS high school lectures. Significant differences were observed among students based on academic performance levels and among teachers based on subject areas. Improvement needs related to videos included course development for both lower-level and higher-level students, separately. For teachers, the most frequent improvement needs were rich teaching materials and level-specific courses. Regarding textbook-related improvement needs, both students and teachers indicated a preference for easily understandable concept explanations and sufficient con-struction of challenging questions.
Conclusions The findings indicate a significant demand for diversified educational content tailored to the students' levels for both video and textbook in EBS high school courses. Addressing the diversification of content in video lectures and textbooks appears to be the most urgent need identified by both students and teachers alike.
A Study on the Visual Recognition Patterns of Japanese Beginner Learners Regarding Hangul Characters: Focusing on Consonant Letters
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Minsoo
Published: February 2024

Objectives The purpose of this study is to examine the visual recognition of Hangul consonants among Japanese beginner learners using data from a visual recognition survey. It aims to identify the consonants that learners find visually challenging to distinguish and to provide educational implications for the instruction of Hangul characters at the introductory level.
Methods An online survey using Google Forms was conducted among 129 Japanese beginner learners studying Korean as an elective liberal arts course at universities in Japan. This survey involved two rounds of visual recog-nition tests on 19 consonant characters. The tests were employing a form constancy testing method where partic-ipants were required to identify Hangul characters that matched the form of the given examples.
Results In comparison to the first survey, the average score of the second survey increased by 0.39 points, but the difference between the average scores of the first and second surveys was not statistically significant. It was also confirmed that the order of learning Hangul characters and their frequency of appearance did not have a sig-nificant effect on the visual recognition of character forms. In the error analysis of Japanese beginner learners, er-rors due to native language, target language, and curriculum were found, and some errors due to native language and target language were interpreted as errors due to the influence of font styles.
Conclusions Japanese beginner learners encounter difficulties in the visual recognition of Hangul characters dur-ing the Korean language learning process. Exposure to these characters in textbooks is insufficient for accurate recognition of their forms, necessitating continuous character form education. It is particularly noted that the de-tailed features of Hangul characters and variations in font styles are significant factors for Japanese learners. This approach is anticipated to serve as foundational data for enhancing understanding of Hangul character learning and for developing effective teaching methods.
La construcción de capacidades estatales en instituciones estratégicas: el caso CNEA (2012-2019)
Authors: Alvez Taylor Lourdes Inés
Published: February 2024

La Comisión Nacional de Energía Atómica (CNEA) es uno de los principales organismos que se vieron atravesados históricamente por las tensiones en torno a las diferentes concepciones del rol del Estado en la intervención en CyT. Reconociendo el rol central que la CNEA ocupa en el campo de la CyT argentina, y su protagonismo en la trama nuclear, resultó de interés para esta investigación analizar la forma específica en se han transformado las capacidades estatales potenciales de la CNEA.De esta forma, siguiendo el objetivo de explorar las capacidades estatales de la CNEA en el periodo 2012-2019, en este trabajo se exponen las transformaciones que se produjeron en el organismo entre el segundo mandato de Cristina Fernández de Kirchner, del 2011 al 2015, y la presidencia de Mauricio Macri, (del 2015 al 2019).La investigación fue realizada a través del análisis de fuentes primarias y secundarias que permitieron caracterizar las capacidades potenciales que el organismo consolidó, así como sus procesos de construcción y de desaprendizaje. Los resultados de la investigación permitieron advertir la existencia de intervenciones en políticas públicas con orientaciones distintivas entre los gobiernos estudiados, así como una respuesta por parte del organismo que se fundó sobre la base de la memoria institucional. Estas tendencias fueron identificadas al realizar un análisis complejo y diacrónico tanto sobre la dimensión organizacional (hardware, software y orgware) como de la dimensión relacional (escenarios de actuación del organismo) de las capacidades del organismo.
Endeudamiento informal: la vivencia de los préstamos no regulados en seis mujeres costarricenses
Authors: Cascante-Vindas Roberto
Published: February 2024

El artículo expone parte de los resultados del proyecto de investigación «Violencia y endeudamiento: mecanismos que coartan los derechos humanos de personas endeudadas en el sector informal costarricense», desarrollado en la Universidad Estatal a Distancia. Bajo un carácter descriptivo, a partir de la revisión de antecedentes nacionales e internacionales y la participación de seis mujeres, se logra comprender el impacto del endeudamiento informal en la historia de vida de la población participante. Como parte de los hallazgos, las personas participantes evidenciaron una serie de privaciones relacionadas con la educación, empleo formal y conocimientos financieros; a su vez, la figura del crédito informal se destina a gastos regulares requeridos para la reproducción de condiciones de vida (pago de alquiler, alimentación o servicios básicos), con montos catalogados como «micro créditos», sujetos a plazos y condiciones definidos a criterio de la persona prestamista; espacio en el cual, se evidencian mecanismos coercitivos de presión y violación a la integridad de la persona (amenazas, daño físico) para pagar la deuda.
Pembelajaran problem based learning (PBL) dengan kerangka kerja TPaCK: kemampuan pemecahan masalah matematis siswa SMA
Authors: Pratidina Dian Aliza , Nindiasari Hepsi
Published: February 2024

This research was conducted to investigate the influence of PBL (Problem-Based Learning) with the TPaCK framework on the mathematical problem-solving abilities of high school students, specifically focusing on the topic of Systems of Linear Equations with Three Variables (SPLTV). The study employed a pre-experimental design using a one-group pretest-posttest approach at a public high school in Kabupaten Serang with Class X IPA 6 as the selected research sample. The participants were chosen through purposive sampling during the first semester of the academic year 2022–2023. Data collection in this study involved pre-tests and post-tests. The data obtained from the initial and final tests was then processed through three stages, namely descriptive data analysis, data  prerequisite test, and hypothesis test The findings of this research demonstrate that PBL with the TPaCK framework can enhance the mathematical problem-solving abilities of high school students.
Kemampuan berpikir kritis dalam memecahkan masalah HOTS
Authors: Nurmalia Navilla Rachma , Sari Christina Kartika
Published: February 2024

Learning math can help students become more adept at using their critical thinking to solve problems. Challenges that require high order thinking skills (HOTS) are one of the questions to practice critical thinking skills. The purpose of this study was to evaluate the ability of junior high school students that require HOTS level problem-solving. This study uses a method that is qualitative and descriptive. The subjects of this study were class IX students at SMP Muhammadiyah 9 Jaten. The data collection technique used was to test the HOTS question instrument in the form of a written test consisting of 3 essay questions and an interview test. Based on the results of the analysis, the research findings show that students' critical thinking skills are still below 50%; the only markers they excelled at were focus and reasoning, which they achieved at 64% and 50%, respectively.