bluuebunny/crossref_metadata_2025 huggingface dataset:
O instituto da delação premiada no combate as organizações criminosas
Authors: Andreza Silva Allan Jones , Silva Luciano Nascimento , Andreza Silva Andrey Jonas
Published: July 2018

Este artigo tem por escopo analisar o instituto da delação premiada a luz da Lei nº 12.850/13, partindo-se de uma perspectiva metodológica dedutiva, utilizando-se de pesquisa bibliográfica para abordar o trato jurídico nacional. Para tanto, busca-se compreender sua pertinência para o combate às organizações criminosas, bem como verificar sua validade segundo ditames éticos e jurídicos. Inicia-se observando a influência destas organizações, sua engrenagem corporativa e a disponibilidade de meios mobilizados para auferir vantagens ilícitas, como também a dificuldade de enfrentamento pelo Estado, não apenas pela escassez ou precariedade de recursos, mas também pela burocracia processual que impossibilita efetivamente desmantelar tais organizações. Para superar esta problemática, a delação premiada demonstra ser um instrumento importante para a persecução penal, sobretudo quando balizada pelos procedimentos estatuídos pela lei 12.850/13, corroborando para a concretização de uma política criminal comprometida com o bem-estar da população e a proteção do Estado Constitucional de Direito.
Da ética geral à ética empresarial
Authors: Mortati Ana Flávia Terra Alves
Published: July 2018

Pretende proceder breve análise, por meio da resenha, da obra Da Ética Geral à Ética Empresarial, de Newton de Lucca.
Desenvolvimento econômico e o abuso do poder “uma visão sobre a dinâmica da economia brasileira diante do abuso do capital”.
Authors: Pinheiro Adilson Ivan Caropreso , Nascimento Décio Estevão do
Published: July 2018

A história da Republica Federativa do Brasil foi marcada por uma serie de planos econômicos e desenvolvimento que, sucedia-se a cada Governante estabelecido. Políticas de industrialização, infraestrutura, de estabilização econômica, controle inflacional e políticas sociais sucumbiram ao tempo e a globalização. Entretanto, a base do capital Liberal perseverou sobre todos os regimes e épocas da modernidade, favorecendo o progresso, mas, também, acumuladores de capital, investidores oportunistas e a corruptores e corruptos. O sistema político deixou-se levar pelo capital em uma crescente necessidade de progresso e modernização o que motivou, por outro lado, uma corrente de oportunismo financeiro montado sobre o capital publico e privado. O presente artigo através de uma análise metodológica da doutrina, Leis e jurisprudências visa apresentar uma visão real das ações, consequências e prevenções dos entes públicos e sociedade na ação abusiva do uso do poder econômico diante de uma visão histórica da evolução industrial e do capital no Brasil, mostrando a linha tênue entre desenvolvimento, progresso social,capital e a oportunidade do abuso e desequilíbrio dos mesmos.
Matriz morfológica e biomimética: geração de alternativas em design
Authors: Brandão Kanda Gisele , De Oliveira Souza Rejane , Barros de Held Maria Sílvia
Published: July 2018

Este artigo discute as possibilidades de uma nova técnica para orientar a concepção de um produto. Foram combinadas a matriz morfológica e a bioinspiração para fornecer um escopo de discussões para o brainstorm que antecede a fase de desenvolvimento do produto. Como exemplo de aplicação, utilizou-se a técnica para a concepção de um maiô esportivo de natação. O projeto foi bioinspirado na superfície corporal, na anatomia e no habitat dos tubarões.
A tropicália de Rogério Duarte em "Caetano Veloso" e "Gilberto Gil" (1968)
Authors: Dos Santos Almeida Fernando , Marques Fuchs Isabela , Kaminski Rosane
Published: July 2018

Este artigo consiste na decodificação da visualidade tropicalista de Rogério Duarte em suas duas peças gráficas: a capa do álbum "Caetano Veloso" (1968) e "Gilberto Gil" (1968). Através da análise formal e simbólica dos impressos, as capas de disco serão descritas a partir de uma abordagem tríplice, na junção de sua dimensão formal, semântica e histórico-social. Trabalhando em questões relativas à resistência cultural no Brasil em uma época efervescente e polêmica de ditadura militar, se pretende refletir as questões referentes a tropicália e em como Rogério Duarte trabalhou com seus conceitos: a busca por uma identidade nacional, o esvaziamento cultural, a resistência e a experiência política junto às massas.
O estranhamento do banal: a poética magritteana sob um olhar psicanalítico
Authors: Bigeli Alan Ricardo Floriano , Dionisio Gustavo Henrique
Published: July 2018

O presente artigo pretende construir possíveis relações entre a psicanálise e algumas das obras mais inquietantes de René Magritte (1898 – 1967), mantendo consonância com a curadoria de uma exposição sobre o artista, chamada “Magritte: The Mystery of the Ordinary”. Para tanto, além de nos debruçarmos sobre materiais de comentadores e críticos da obra do pintor, investigamos também os textos produzidos pelo próprio Magritte, nos quais o pintor versa sobre conceitos fundamentais para a compreensão de seu pensamento artístico: emoção estética, poética, mistérios do cotidiano, estranhamento (ressoante ao Umheimlich freudiano). Tivemos aqui o cuidado de manter alguma distância de interpretações superficiais e reducionistas, que simplesmente aplicassem a psicanálise à obra de arte. Portanto, buscamos construir uma leitura crítica, atenta aos detalhes e atravessamentos que percorrem as obras de arte, evidenciando as implicações ali presentes e propondo aproximações entre a obra de Magritte e a teoria psicanalítica.
A modernização do campo e o processo de descolamento da cidade: Lavras do Sul – município da região da Campanha gaúcha
 Rural Modernization and the Process of Urban Displacement: Lavras do Sul – a City Located in the Campanha Region of the State of Rio Grande do Sul
Authors: Fontoura Luiz Fernando Mazzini
Published: July 2018

Este trabalho visa avaliar as alterações na relação campo-cidade em função da substituição da atividade pecuária bovina tradicional por outras formas de produção empresarial em alguns municípios pequenos localizados na região da Campanha gaúcha, especificamente em Lavras do Sul. O objetivo da pesquisa é entender as transformações causadas pela modernização da agricultura no campo e que têm provocado um descolamento entre o campo e a cidade, que muitas vezes não acompanha este movimento, analisados a partir do comportamento das migrações populacionais no campo e na cidade paralelo ao avanço da modernização da agricultura.Abstract The present paper aims to assess the changes in the countryside-city relationship regarding the replacement of traditional cattle breeding activity by other types of entrepreneurial production in some small cities located in the Campanha region of Rio Grande do Sul, specifically in Lavras do Sul, based on the study of small cities, from the landscape and production systems analysis. The purpose of the paper is to gain insight on the changes caused by agricultural modernization, which led to population displacement between the countryside and the cities. Analysis of these changes was based on the observation of the pattern of migration flows in the rural and urban areas, alongside with the increased agricultural modernization.
A Geografia e a Cartografia Produzidas na Antiguidade: a contribuição dos clássicos
 The Geography and Cartography Produced in Antiquity: the Contribution of the Classics
Authors: Colaço Douglas
Published: July 2018

Este texto é parte da pesquisa desenvolvida e defendida junto ao Programa de Pós-Graduação Stricto Sensu em Geografia pela Universidade Estadual do Oeste do Paraná. A pesquisa teve o seguinte título: “A unidade de perspectivas entre a geografia e a cartografia medievais: paralelos com as artes visuais”. Contudo, no capítulo I, buscou-se conhecer e compreender a Geografia (e a Cartografia) produzida na Antiguidade Clássica. Desse modo, na integralidade da pesquisa foi possível compreender alguns traços do pensamento geográfico e do cartográfico greco-romano, e comparar as variações conceituais e metodológicas em relação ao conhecimento geográfico e cartográfico produzidos na Idade Média. Sobre a Antiguidade Clássica, evidentemente, os pensadores gregos e romanos não foram os únicos, nem os primeiros, a produzir um conhecimento geográfico (e cartográfico), mas certamente, foram eles os primeiros a melhor sistematizar tais conhecimentos.AbstractThis text is part of the research developed and defended at the Graduate Program Stricto Sensu in Geography from the State University of Western Paraná. The research had the following title: "The unity of outlook between geography and medieval cartography: parallel with the visual arts." However, in Chapter I , I tried to know and understand the geography ( and Cartography ) produced in Classical Antiquity . Thus, in the whole of the research was possible to understand some aspects of geographical thought and the Greco-Roman cartographic, and compare the conceptual and methodological changes in relation to geographic and cartographic knowledge produced in the Middle Ages. On Classical Antiquity, of course, the Greek and Roman thinkers were not the only, nor the first, producing a geographical knowledge (and mapping), but certainly they were the first ones to better systematize such knowledge.
Ciclo de Crescimento da Economia Brasileira e Desempenho do Agronegócio Catarinense
 The Brazilian Economy Growth Cycle and Agribusiness Performance in Santa Catarina
Authors: Espindola Carlos José
Published: July 2018

O período compreendido entre 2003-2011 configura-se na economia brasileira como um ciclo de crescimento impulsionado por fatores internos e externos. Nesse ciclo merece destaque o dinamismo produtivo e comercial do agronegócio brasileiro e catarinense. Assim sendo, o objetivo geral deste texto é desvendar o desempenho do agronegócio catarinense, procurando identificar as múltiplas determinações responsáveis pela dinâmica recente dos agronegócios catarinense no território brasileiro e a sua consolidação no mercado internacional AbstractThe period between 2003 and 2011 represents a growing cycle driven by internal and external factors, in the Brazilian economy. In that period, it is worth highlighting the productive and commercial dynamism of the Brazilian and Catarinense agribusiness. Therefore, the text objective is to reveal the performance of Santa Catarina agribusiness, seeking to identify the multiple determinants responsible for recent dynamics of the Catarinense agribusiness, in the Brazilian territory, and its consolidation in the international market.
Formação inicial de professores de geografia: entre expectativa e realidade a ação do PIBID
Authors: Sene Michael Wellington , De Freitas Vilas Boas Gomes Marquiana
Published: July 2018

A profissão docente é complexa, pois integra produção do conhecimento e relações humanas. Estas relações implicam ao docente construir um conjunto de estratégias que não se restrinjam apenas a contribuir com o desenvolvimento cognitivo do estudante, mas também, envolver-se em uma trama de dimensões culturais, sociais e psicológicas próprias do interagir com o outro. Discutir as dificuldades e potencialidades da formação de professores se faz necessário, tendo em vista que estes profissionais são responsáveis por boa parte da melhoria na qualidade da educação. É neste contexto, que este trabalho visa discutir o processo de formação docente a partir de projetos colaborativos entre universidade e escola, analisar as contribuições e limites da formação inicial aliada ao PIBID e os Novos Talentos, ambos financiados pela CAPES. Nele, analisa-se como o PIBID e os Novos Talentos estão sendo inseridos no curso de formação inicial de professores de Geografia da Universidade Estadual do Centro-Oeste – UNICENTRO, campus CEDETEG, localizado na cidade de Guarapuava-PR. Para isso, utilizar-se-á a metodologia da pesquisa participante. Apresentam-se aqui alguns resultados alcançados a partir da pesquisa realizada com alunos (pibidianos e não pibidianos) da quarta série do curso de licenciatura em Geografia, e de observações realizadas no PIBID e na implementação dos Novos Talentos, com as quais foi possível analisar as contribuições destes programas para a formação profissional docente. A pesquisa realizada evidenciou que ambos os programas têm sido fundamentais para a formação inicial e continuada de professores, sobretudo pela troca de experiências entre universidade e escola.
Refugiados em Quadrinhos: proposta de ensino de geografia nos cursos integrados do IFSP – Campus Avaré/SP
Authors: Ricciardi Floriano Silva Juliano , Oriane da Silva Diânice
Published: July 2018

Este artigo é resultado de um projeto de ações de ensino, na modalidade de monitoria, realizada no Campus do IFSP, na cidade de Avaré, estado de São Paulo. O intuito desse projeto foi desenvolver com os alunos do ensino técnico integrado ao ensino médio, uma proposta de emprego da arte sequencial das histórias em quadrinhos na disciplina de Geografia. A arte sequencial é utilizada desde o entretenimento infanto-juvenil na forma das HQs como também é uma técnica adotada no cinema, na forma de storyboards, usada no planejamento de cenas que serão rodadas em cenários distintos. Acredita-se que essa linguagem pode ser utilizada também, com finalidades didático-pedagógicas, por isso, foram adaptados relatos de refugiados, que no momento de sua aplicação recheavam os noticiários internacionais, mostrando o drama dessas pessoas que se deslocavam em busca de uma vida melhor. Após a introdução e sensibilização ao tema, realizado pelo docente e o auxílio do bolsista/monitor, os alunos pesquisaram outros relatos de refugiados e transformaram em histórias em quadrinhos, que podem ser consultados na rede mundial de computadores.
Avaliação de impactos socioambientais na Gruta da Lapinha, Lagoa Santa/MG e seu entorno pela atividade turística
Authors: Vieira Xavier Fernanda , Deslandes Ribas Rafael , Moreira Braz Adalto
Published: July 2018

O presente trabalho teve como objetivo principal avaliar qualitativamente as interferências decorrentes da atividade turística que ocorrem na gruta da Lapinha em Minas Gerais, caracterizando seus aspectos socioambientais e identificando seus impactos ocorridos em função da visitação turística. Foi realizado um levantamento bibliográfico e pesquisas em campo para identificar um panorama da atual situação da gruta, além da realização da matriz de correlação através do método Check List a fim de avaliar os principais impactos. Os resultados mostraram diferentes percepções da comunidade sobre a preservação do patrimônio além de apontar os principais problemas decorrentes da degradação ambiental da área. Como considerações finais, foram realizadas recomendações para melhoria da preservação e da relação da comunidade com a Unidade de Conservação.
Proposta de adequação ambiental de propriedades rurais por meio de Sistema de Informações Geográfica – SIG
Authors: Henrique Soares da Silva Mauro , Rocha Dias Nara
Published: July 2018

A presente pesquisa objetivou a aplicação de técnicas de geoprocessamento e manipulação de dados em ambiente SIG para a adequação ambiental de propriedade rural, com apoio de ferramentas gratuitas e/ou de fácil aquisição. Assim, os procedimentos desta pesquisa foram aplicados, em uma propriedade rural experimental, sendo, portanto selecionada a Fazenda Casa Grande, localizada em Campo Grande – MS. Realizou-se um mapeamento da área de estudo, pautado no levantamento das áreas de proteção legal da propriedade, a identificação de áreas degradadas e uma síntese e proposta de adequação ambiental. As atividades basearam-se no uso de imagens do Google Earth e do satélite Landsat-8, trabalhadas por meio do software gratuito Quantum Gis, além de dados levantados em campo. A propriedade rural estudada apresentou irregularidades quanto às leis do novo código florestal, sendo necessária assim a aplicação de Termo de Compromisso de Restauração para o estabelecimento de uma Reserva Legal. Será também necessária a recuperação de erosões na área de estudo. Para tanto deverá ser implementado um plano de adequação ambiental na área de estudo para minimizar a degradação dos recursos hídricos e dos demais elementos do meio ambiente.
Sociedade e natureza no Pontal do Paranapanema - SP: a unidade da geografia e o desenvolvimento regional
Authors: Santos Ricardo dos , Coca Estevan Leopoldo de Freitas
Published: July 2018

Nesse texto a Geografia é entendida na perspectiva de sua totalidade, de modo que sociedade e natureza se relacionam por meio de um processo dialético. Tendo essa referência, é feita a defesa de que ações que visam contribuir com o desenvolvimento regional devem levar em consideração todas as dimensões da realidade e não apenas a econômica, como tem sido comum no modelo capitalista. Como recorte é utilizada a região do Pontal do Paranapanema, no Estado de São Paulo. Destaca-se como no Pontal do Paranapanema coexistem diferentes modelos de desenvolvimento, todavia, a prevalência tem sido o de cunho capitalista.
Beroepsrisico’s bij slachtoffer-daderbemiddeling: bescherming of kwaliteitsondersteuning?
Authors: Verbeeck Pieter , Deboeck Hilde
Published: July 2018

Professional risks concerning victim-offender mediation: to protect of to support?

The article provides a description of the issues and considerrations facing Flemish victim-offender mediators on the job. Instead of focusing on professinal risks and caveats present within victim-offender mediation, the authors concentrate on the positive concept of ‘enabling high quality mediations’. A description is given of the frames that are felt to be helpful towards mediators, stressing the need to act with due creativity if needed. Moreover, in order to enable high quality victim-offender mediations, conditions need to be met, more specifically a common acknowledgment of the need for teamwork. The latter implies conditions such a sound legal basis, a deontological code, formal procedures and constant interaction with practice.
Tumor Budding in Colorectal Carcinoma: Translating a Morphologic Score Into Clinically Meaningful Results
Authors: Cho Soo-Jin , Kakar Sanjay
Published: July 2018

Context.—

Tumor budding has received increasing recognition as an important independent prognostic factor in colorectal carcinoma. Prominent tumor budding in adenocarcinoma arising in a polyp has been shown to be a risk factor for lymph node involvement. The variability in methods used for evaluating tumor budding in different studies and lack of standardized guidelines have impeded routine inclusion of tumor budding in pathology reports. This changed last year with consensus guidelines based on the International Tumor Budding Consensus Conference (ITBCC). These guidelines have been included in the recent College of American Pathologists (CAPs) Colorectal Cancer Protocol. The consensus methodology will allow uniform reporting of this finding, but challenges in interpretation in the setting of intense inflammation, fibrosis, or gland fragmentation need to be addressed in future guidelines.

Objective.—

To provide a brief overview of the known clinical significance of tumor budding in colorectal carcinoma and discuss the practical aspects of its implementation on a routine basis.

Data Sources.—

English-language pathology literature.

Conclusions.—

Tumor budding has been shown to be an independent prognostic marker in colorectal carcinomas and the routine reporting of tumor buds is now advocated by using the approach outlined by the ITBCC guidelines. Tumor budding is included in the CAP protocol as a recommended element. Presence of prominent tumor budding in an adenocarcinoma in a polyp may have implications for management, such as additional resection, while it serves as a prognostic factor in other settings.
Cutaneous Spindle Cell Neoplasms: Pattern-Based Diagnostic Approach
Authors: Choi Joon Hyuk , Ro Jae Y.
Published: July 2018

Context.—

Spindle cell neoplasms arising in the skin comprise a heterogeneous group of tumors with divergent lineages. Cutaneous spindle cell neoplasms are relatively common and present surgical pathologists with diagnostic challenges. Recognition of their histopathologies is important for correct diagnosis and management. The current review presents a pattern-based diagnostic approach to common cutaneous spindle cell neoplasms that often cause diagnostic difficulties.

Objective.—

To provide a useful guide for diagnosis of cutaneous spindle cell neoplasms.

Data Sources.—

PubMed (US National Library of Medicine) reports and the authors' personal experiences are reviewed.

Conclusions.—

The authors briefly summarize the histologic features and differential diagnoses of common cutaneous spindle cell neoplasms.
Shelley’s Living Artistry: Letters, Poems, Plays
Authors: Callaghan Madeleine
Published: July 2018

This study of the poetry and drama of Percy Bysshe Shelley reads the letters and their biographical contexts to shed light on the poetry, tracing the ambiguous and shifting relationship between the poet’s art and life. For Shelley, both life and art are transfigured by their relationship with one another, where the ‘poet participates in the eternal, the infinite, and the one’, but is equally bound up with and formed by the society in which he lives and the past that he inherits. Callaghan shows that the distinctiveness of Shelley’s work comes to rest on its wrong-footing of any neat division of life and art. The dazzling intensity of Shelley’s poetry and drama lies in its refusal to separate the twain as Shelley explores and finally explodes the boundaries between what is personal and what is poetic. Arguing that the critic, like the artist, cannot ignore the conditions of the poet’s life, Callaghan reveals how Shelley’s artistry reconfigures and redraws the actual in his poetry. The book shows how Shelley’s poetic daring lies in troubling the distinction between poetry as aesthetic work hermetically sealed against life, and poetry as a record of the emotional life of the poet.
Prevalence and extent of chronic periodontitis and its risk factors in a Portuguese subpopulation: a retrospective cross-sectional study and analysis of Clinical Attachment Loss
Authors: Machado Vanessa , Botelho João , Amaral António , Proença Luís , Alves Ricardo , Rua João , Cavacas Maria Alzira , Delgado Ana Sintra , Mendes José João
Published: July 2018

Objectives

To assess the prevalence and extent of chronic periodontitis, and its risk factors in a Portuguese subpopulation referred to periodontal examination.

Methods

This retrospective cross-sectional study used a subset of data from patients who sought dental treatment in a university dental clinic in the Lisbon metropolitan area. The sample consisted of 405 individuals (225 females/180 males), aged 20–90 years. All patients underwent a full-mouth periodontal examination and chronic periodontitis was defined as Clinical Attachment Loss (CAL) ≥ 3 mm affecting two or more teeth. Aggressive periodontitis cases were excluded from the analysis.

Results

Prevalence of chronic periodontitis was 83.5% (95% CI [80.4–86.6%]). For these subjects, CAL ≥ 3 mm affected 86.0% (95% CI [84.7–87.2]) of sites and 83.7% (95% CI [81.7–85.6]) of teeth, respectively. Mean CAL ranged from 3.6 to 4.3 mm, according to age. In the multivariate logistic regression model, smoking (OR = 3.55, 95% CI [1.80–7.02]) and older age (OR = 8.70, 95% CI [3.66–20.69] and OR = 4.85, 95% CI [2.57–9.16]), for 65+ and 45–64 years old, respectively, were identified as risk indicators for CAL ≥ 3 mm.

Conclusions

This particular Portuguese adult subpopulation had a high prevalence of chronic periodontitis, with severe and generalized clinical attachment loss, and its presence was significantly associated with age and smoking. This data should serve to prepare future detailed epidemiological studies and appropriate public health programs.
Imputing missing distances in molecular phylogenetics
Authors: Xia Xuhua
Published: July 2018

Missing data are frequently encountered in molecular phylogenetics, but there has been no accurate distance imputation method available for distance-based phylogenetic reconstruction. The general framework for distance imputation is to explore tree space and distance values to find an optimal combination of output tree and imputed distances. Here I develop a least-square method coupled with multivariate optimization to impute multiple missing distance in a distance matrix or from a set of aligned sequences with missing genes so that some sequences share no homologous sites (whose distances therefore need to be imputed). I show that phylogenetic trees can be inferred from distance matrices with about 10% of distances missing, and the accuracy of the resulting phylogenetic tree is almost as good as the tree from full information. The new method has the advantage over a recently published one in that it does not assume a molecular clock and is more accurate (comparable to maximum likelihood method based on simulated sequences). I have implemented the function in DAMBE software, which is freely available athttp://dambe.bio.uottawa.ca.
Presence of Aberrant Anatomy Is an Independent Predictor of Bile Duct Injury During Cholecystectomy
Authors: Natsume Seiji , Kato Takehito , Hiramatsu Kazuhiro , Shibata Yoshihisa , Yoshihara Motoi , Aoba Taro , Aiba Toshisada , Takada Akira
Published: July 2018

The aim of this study is to investigate the impact of an aberrant anatomy diagnosed with MR cholangiography on the occurrence of bile duct injury. Although many authors report that aberrant anatomy is a strong risk factor for the occurrence of bile duct injury during cholecystectomy, no reports have examined the incidence of aberrant anatomy and its association as an independent risk factor for bile duct injury while controlling for potential confounding factors. This study involved 1289 patients. All images of MR cholangiography were reviewed and the findings, including the presence of aberrant anatomy, thickening of the gallbladder wall, and cystic duct stones—which may be related to the occurrence of bile duct injury—were recorded. The surgical outcome was compared according to the presence or absence of an aberrant anatomy and the predictive factors for bile duct injury were investigated. Aberrant anatomy was present in 11.2% of cases. The incidence of bile duct injury was significantly higher in patients with aberrant anatomy compared with patients without (3.5% versus 0.3%). By multivariate analysis, the presence of an aberrant anatomy and thickening of the gallbladder wall was an independent predictor for bile duct injury occurrence [odds ratio (OR) =16.56, P = 0.001; OR = 10.96, P = 0.006, respectively]. The presence of an aberrant anatomy and thickening of the gallbladder wall is an independent risk factor for the occurrence of bile duct injury.
Lesbianidade Política na Bahia: que ginga é essa?
Authors: Da Silva Zuleide Paiva
Published: July 2018

Reconhecendo a lesbianidade como ato de resistência (CLARKE, 1990), tomo as organizações lésbicas como objeto de estudo, apreendendo a experiência (SCOTT, 1998) como ponto de partida dessa reflexão. Situada no campo dos estudos feministas de gênero e sexualidade, reconheço que todo conhecimento é localizado (HARAWAY, 1995) e percebo a ginga como produção de conhecimento feminista (ARAUJO, 2015). Orientada pelo paradigma feminista “o Pessoal é Político” e pelos paradigmas “Exu” e “América Latina”, meu propósito neste texto é apresentar dimensões histórica, política e cognitiva das organizações lésbicas da Bahia que se reconhecem e são reconhecidas como expressões dos novos movimentos sociais (GOHN, 2012). O trabalho reconhece a lesbianidade política na Bahia como ginga pela (re)existência lésbica, uma luta iniciada na capital baiana no tempo da ditadura militar, e sugere que, a partir dos anos 2000, a ginga lésbica se expandiu em rede, seguindo em “continuum lésbico” (RICH,1980) pela região metropolitana de Salvador e interior do Estado. Sem nenhuma pretensão de verdade, ressalto que este é um saber militante (MERHY,2008) - reflexões de uma sujeita implicada que se pretende epistêmica.
Pensamento Lésbico e Formação da Crítica Queer of Color
Authors: Rea Caterina Alessandra
Published: July 2018

Este texto entende refletir sobre as contribuições de autoras lésbicas para a produção da Teoria Queer e, particularmente, da Crítica Queer de cor (Queer of Color Critique). Partindo da consideração de Randy Conner para quem Gloria Anzaldúa foi a primeira a usar o termo queer no contexto da escrita acadêmica, podemos considerar uma outra gênese de Queer, no campo das produções de autoras lésbicas não-brancas. Mostraremos que a crítica Queer of Color tematiza, hoje, a importância de coletivos lésbicos de cor e a maneira em que esses questionam as políticas LGBT meanstream, particularmente, nos países centrais. A chegada da teoria queer para o continente africano, também, revela o protagonismo de mulheres lésbicas acadêmicas e ativistas.
Contra-amor, poliamor, relaciones abiertas y sexo casual, de Norma Mongrovejo
Authors: Silva Ariana Mara da
Published: July 2018

Resenha de livro
Efficient 4,4′,4″‐tris(3‐methylphenylphenylamino)triphenylamine (m‐MTDATA) Hole Transport Layer in Perovskite Solar Cells Enabled by Using the Nonstoichiometric Precursors
Authors: Liu Chunyu , Zhang Dezhong , Li Zhiqi , Zhang Xinyuan , Shen Liang , Guo Wenbin
Published: July 2018

To overcome the drawbacks of the acidic and hygroscopic nature of the poly(3,4‐ethylenedio‐xythiophene):poly(styrenesulfonate) hole transport layer (HTL), the p‐type polymeric hole transport materials have attracted great attention and have been applied into perovskite solar cells. Here, a starburst amine molecule 4,4′,4″‐tris(3‐methylphenylphenylamino)triphenylamine (m‐MTDATA) without any additive is demonstrated as an effective hole transport material in perovskite solar cells. Meanwhile, considering the different surface affinity of precursor's composition on m‐MTDATA, the influence of the molar ratios between lead iodine (PbI2) and methylammonium iodide in precursor solution on the perovskite characteristics and device performance is investigated in‐depth. Ultimately, an enhanced efficiency of 17.73% and a high fill factor of 79.6% are achieved, which attribute to the strong passivation effect of traps and small resistance loss from appropriate unreacted PbI2 left in the perovskite layer. This work not only provides a remarkable HTL, but also reveals that the adjustment of precursor ratio is necessary for the one‐step solution approach, because the affinities of precursor's composition may be different with the underlying transport layers.
Electrical Behavior and Electron Transfer Modulation of Nickel–Copper Nanoalloys Confined in Nickel–Copper Nitrides Nanowires Array Encapsulated in Nitrogen‐Doped Carbon Framework as Robust Bifunctional Electrocatalyst for Overall Water Splitting
Authors: Hou Jungang , Sun Yiqing , Li Zhuwei , Zhang Bo , Cao Shuyan , Wu Yunzhen , Gao Zhanming , Sun Licheng
Published: July 2018

Probing robust electrocatalysts for overall water splitting is vital in energy conversion. However, the catalytic efficiency of reported catalysts is still limited by few active sites, low conductivity, and/or discrete electron transport. Herein, bimetallic nickel–copper (NiCu) nanoalloys confined in mesoporous nickel–copper nitride (NiCuN) nanowires array encapsulated in nitrogen‐doped carbon (NC) framework (NC–NiCu–NiCuN) is constructed by carbonization‐/nitridation‐induced in situ growth strategies. The in situ coupling of NiCu nanoalloys, NiCuN, and carbon layers through dual modulation of electrical behavior and electron transfer is not only beneficial to continuous electron transfer throughout the whole system, but also promotes the enhancement of electrical conductivity and the accessibility of active sites. Owing to strong synergetic coupling effect, such NC–NiCu–NiCuN electrocatalyst exhibits the best hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) performance with a current density of 10 mA cm−2 at low overpotentials of 93 mV for HER and 232 mV for OER, respectively. As expected, a two‐electrode cell using NC–NiCu–NiCuN is constructed to deliver 10 mA cm−2 water‐splitting current at low cell voltage of 1.56 V with remarkable durability over 50 h. This work serves as a promising platform to explore the design and synthesis of robust bifunctional electrocatalyst for overall water splitting.
Interfering with Lactate‐Fueled Respiration for Enhanced Photodynamic Tumor Therapy by a Porphyrinic MOF Nanoplatform
Authors: Chen Zhao‐Xia , Liu Miao‐Deng , Zhang Ming‐Kang , Wang Shi‐Bo , Xu Lu , Li Chu‐Xin , Gao Fan , Xie Bo‐Ru , Zhong Zhen‐Lin , Zhang Xian‐Zheng
Published: July 2018

Lactate is a prominent energy substrate for oxidative tumor cells. Interfering with the lactate‐fueled respiration of oxidative tumor cells would be a promising therapeutic strategy for cancer treatment. In this study, α‐cyano‐4‐hydroxycinnamate (CHC) is incorporated into a porous Zr (IV)‐based porphyrinic metal‐organic framework (PZM) nanoparticle, to reduce the lactate uptake by inhibiting the expression of lactate‐proton symporter, monocarboxylate transporter 1 (MCT1) in tumor cells, thus transform lactate‐fueled aerobic respiration to anaerobic glycolysis. The alteration in energy supply can also decrease the oxygen consumption in tumor cells, which would facilitate the photodynamic therapy (PDT) in cancer treatment. Moreover, hyaluronic acid (HA) is coated on the surface of PZM nanoparticles for CD44‐targeting and hyaluronidase‐induced intracellular drug releasing. Both in vitro and in vivo studies confirmed good biocompatibility and enhanced PDT efficacy of the HA‐coated PZM nanoparticles (CHC‐PZM@HA) in tumor cells. The CHC‐PZM@HA platform will provide a new perspective in cancer therapy.
Cutaneous B‐cell lymphomas: 2019 update on diagnosis, risk stratification, and management
Authors: Wilcox Ryan A.
Published: July 2018

Disease overview

Approximately one‐fourth of cutaneous lymphomas are B‐cell derived and are generally classified into three distinct subgroups: primary cutaneous follicle center lymphoma (PCFCL), primary cutaneous marginal zone lymphoma (PCMZL), and primary cutaneous diffuse large B‐cell lymphoma, leg type (PCDLBCL, LT).

Diagnosis

Diagnosis and disease classification are based on histologic review and immunohistochemical staining of an appropriate skin biopsy. Pathologic review and an appropriate staging evaluation are necessary to distinguish primary cutaneous B‐cell lymphomas from systemic B‐cell lymphomas with secondary skin involvement.

Risk stratification

Disease histology remains the most important prognostic determinant. Both PCFCL and PCMZL are indolent lymphomas that infrequently disseminate to extracutaneous sites and are associated with 5‐year survival rates that exceed 95%. In contrast, PCDLBCL, LT is an aggressive lymphoma with an inferior prognosis.

Risk‐adapted therapy

PCFCL and PCMZL patients with solitary or relatively few skin lesions may be affectively managed with local radiation therapy. While single‐agent rituximab may be employed for patients with more widespread skin involvement, multiagent chemotherapy is rarely appropriate. In contrast, management of patients with PCDLBCL, LT is comparable to the management of patients with systemic DLBCL.
Modulating Photo‐ and Electroluminescence in a Stimuli‐Responsive π‐Conjugated Donor–Acceptor Molecular System
Authors: Isayama Kohei , Aizawa Naoya , Kim Jun Yun , Yasuda Takuma
Published: July 2018

Functional organic materials that display reversible changes in fluorescence in response to external stimuli are of immense interest owing to their potential applications in sensors, probes, and security links. While earlier studies mainly focused on changes in photoluminescence (PL) color in response to external stimuli, stimuli‐responsive electroluminescence (EL) has not yet been explored for color‐tunable emitters in organic light‐emitting diodes (OLEDs). Here a stimuli‐responsive fluorophoric molecular system is reported that is capable of switching its emission color between green and orange in the solid state upon grinding, heating, and exposure to chemical vapor. A mechanistic study combining X‐ray diffraction analysis and quantum chemical calculations reveals that the tunable green/orange emissions originate from the fluorophore's alternating excited‐state conformers formed in the crystalline and amorphous phases. By taking advantage of this stimuli‐responsive fluorescence behavior, two‐color emissive OLEDs were produced using the same fluorophore in different solid phases.
Chiral Carboxylic Acid Enabled Achiral Rhodium(III)‐Catalyzed Enantioselective C−H Functionalization
Authors: Lin Luqing , Fukagawa Seiya , Sekine Daichi , Tomita Eiki , Yoshino Tatsuhiko , Matsunaga Shigeki
Published: July 2018

Reported is an achiral CpxRhIII/chiral carboxylic acid catalyzed asymmetric C−H alkylation of diarylmethanamines with a diazomalonate, followed by cyclization and decarboxylation to afford 1,4‐dihydroisoquinolin‐3(2H)‐one. Secondary alkylamines as well as nonprotected primary alkylamines underwent the transformation with high enantioselectivities (up to 98.5:1.5 e.r.) by using a newly developed chiral carboxylic acid as the sole source of chirality to achieve enantioselective C−H cleavage by a concerted metalation‐deprotonation mechanism.
Enhanced Tubulation of Liposome Containing Cardiolipin by MamY Protein from Magnetotactic Bacteria
Authors: Tanaka Masayoshi , Suwatthanarak Thanawat , Arakaki Atsushi , Johnson Benjamin R. G. , Evans Stephen D. , Okochi Mina , Staniland Sarah S. , Matsunaga Tadashi
Published: July 2018

Lipid tubules are of particular interest for many potential applications in nanotechnology. Among various lipid tubule fabrication techniques, the morphological regulation of membrane structure by proteins mimicking biological processes may provide the chances to form lipid tubes with highly tuned structures. Magnetotactic bacteria synthesize magnetosomes (a unique prokaryotic organelle comprising a magnetite crystal within a lipid envelope). MamY protein is previously identified as the magnetosome protein responsible for magnetosome vesicle formation and stabilization. Furthermore, MamY is shown in vitro liposome tubulation activity. In this study, the interaction of MamY and phospholipids is investigated by using a lipids‐immobilized membrane strip and a peptide array. Here, the binding of MamY to the anionic phospholipid, cardiolipin, is found and enhanced liposome tubulation efficiency. The authors propose the interaction is responsible for recruiting and locating cardiolipin to elongate liposome in vitro. The authors also suggest a similar mechanism for the invagination site in magnetosomes vesicle formation, where the lipid itself contributes further to increasing the curvature. These findings are highly important to develop an effective biomimetic synthesis technique of lipid tubules and to elucidate the unique prokaryotic organelle formation in magnetotactic bacteria.
Differentially expressed lncRNAs and mRNAs identified by NGS analysis in colorectal cancer patients
Authors: Li Meng , Zhao Lian‐mei , Li Suo‐lin , Li Jing , Gao Bo , Wang Fei‐fei , Wang Sheng‐pu , Hu Xu‐hua , Cao Jian , Wang Gui‐ying
Published: July 2018

Long noncoding RNAs (lncRNAs) play an important role in gene regulation, but their impact on the pathogenesis of colorectal cancer and the biological function of cancer cells is unclear. In this study, we used next‐generation sequencing to study the differences in the expression profiles of lncRNAs and mRNAs in colorectal cancer tissues. We analyzed the differentially expressed genes by Gene Ontology/Kyoto Encyclopedia of Genes and Genomes (GO/KEGG) enrichment and predicted new lncRNA functions. Our results revealed that compared with lncRNAs and mRNAs in nontumor colorectal tissues, 1019 lncRNAs (512 upregulated, 507 downregulated) and 3221 mRNAs (1606 upregulated, 1615 downregulated) were differentially expressed in tumor colorectal tissues (fold change >2 and P < 0.05). We validated some of these genes by qPCR. Furthermore, we identified some new lncRNAs differently expressed in colorectal cancer samples from patients in northern China. We confirmed the function of lncRNA‐FIRRE‐201 and SLCO4A1‐AS1‐202 in colorectal cancer cells to provide an experimental basis for studies on their roles in the occurrence and development of colorectal cancer and in the regulation of networks.
Enzymatic Formation of Oxygen‐Containing Heterocycles in Natural Product Biosynthesis
Authors: Meng Song , Tang Gong‐Li , Pan Hai‐Xue
Published: July 2018

Oxygen‐containing heterocycles are widely encountered in natural products that display diverse pharmacological properties and have potential benefits to human health. The formation of O‐heterocycles catalyzed by different types of enzymes in the biosynthesis of natural products not only contributes to the structural diversity of these compounds, but also enriches our understanding of nature's ability to construct complex molecules. This minireview focuses on the various modes of enzymatic O‐heterocyclization identified in natural product biosynthesis and summarizes the possible mechanisms involved in ring closure.
Angiographic Anatomy of the Left Kugel's Artery
Authors: Grollman J. H. , Heger Leos
Published: July 2018

The left Kugel's artery is an uncommon but sometimes important collateral between the proximal circumflex artery and whatever artery supplies the crux of the heart. It passes anterior to the mitral valve ring, coursing in the interatrial septum, to anastomose usually with the atrioventricular node artery. The left Kugel's artery was prospectively identified on coronary arteriograms in 3.6% of patients with significant disease in dominant circumflex or right coronary arteries with associated collateral circulation. It was occasionally as large as 1 mm in diameter. The angiographic anatomy of this vessel is described
A Remarkable Catalytic Activity of Hierarchical Zeolite (ZH‐5) for Tertiary Butylation of Phenol with Enhanced 2,4‐Di‐t‐Butylphenol Selectivity
Authors: Parsapur Rajesh K. , Selvam Parasuraman
Published: July 2018

Hierarchical zeolites with the ordered arrangement at the nanoscopic level are of paramount importance in catalysis owing to their remarkable properties. Nevertheless, architecting such structures is extremely difficult owing to their challenging synthesis conditions. In this study, we report a designed synthesis of such a material with MFI topology viz., hierarchical nanoporous ZSM‐5 (designated as ZH‐5) with unique serrated morphologies. The synthetic approach was envisaged by considering the stable supramolecular aggregation, controlled zeolitization and strong organosilane interactions as the key factors for the hierarchical organization. Furthermore, for the first time, we emphasize the effect of dual‐templating nature of organosilanes in stabilizing the crystalline mesophase for the development of a hierarchical pore‐architecture. In addition, the catalysts have shown remarkable catalytic activities for the formation of 2,4‐di‐tert‐butylphenol.
Removal of methyl violet dye by a low‐cost waste (Ajuga Pseudo‐Iva): Kinetic and equilibrium isotherm study
Authors: Behloul Samia , Hamitouche Adhya‐Eddine , Haffas Maamar , Boudjemaa Amel , Benammar Souad , Sehailia Moussa , Meziane Toufik , Bachari Khaldoun
Published: July 2018

In this work we describe the utilization of a low cost environmental biomass derived from Ajuga Pseudo‐Iva waste (AP‐Iva) for the purpose of dye removal from contaminated wastewater. The biosorbent was characterized by SEM, ATG‐DSC, and FTIR‐ATR techniques. The material's performance was studied by varying operating parameters such as initial dye concentration, pH, adsorbent dose, particle size, and contact time. The results obtained showed that MV dye was sorbed quickly enough for the first few minutes and achieved a good efficiency (∼80 %) after 30 min of reaction time. The kinetic data obtained at different concentrations were analyzed using pseudo‐first order, pseudo‐second order, Elovich, and intra‐particle diffusion models. The equilibrium sorption data were analyzed using Freundlich, Langmuir, Toth, Sips, and Temkin isotherms. The experimental data were correctly fitted to Toth and Sips isotherms.
Prevalence and pharmacologic management of familial hypercholesterolemia in an unselected contemporary cohort of patients with stable coronary artery disease
Authors: De Luca Leonardo , Arca Marcello , Temporelli Pier L. , Colivicchi Furio , Gonzini Lucio , Lucci Donata , Bosco Biagio , Callerame Mariella , Lettica Giulio V. , Di Lenarda Andrea , Gulizia Michele M. ,   on behalf of the START Investigators
Published: July 2018

Introduction

Familial hypercholesterolemia (FH) is an inherited disorder characterized by elevated plasma levels of low‐density lipoprotein cholesterol (LDL‐C) associated with premature cardiovascular disease.

Methods

Using the data from the START (STable Coronary Artery Diseases RegisTry) study, a nationwide, prospective survey on patients with stable coronary artery disease (CAD), we described prevalence and lipid lowering strategies commonly employed in these patients. The study population was divided into “definite/probable FH,” defined as a Dutch Lipid Clinic Network (DLCN) score ≥6, “possible FH” with DLCN 3‐5, and “unlikely FH” in presence of a DLCN <3.

Results

Among the 4030 patients with the DLCN score available, 132 (3.3%) were classified as FH (2.3% with definite/probable and 1.0% with possible FH) and 3898 (96.7%) had unlikely FH. Patients with both definite/probable and possible FH were younger compared to patients not presenting FH. Mean on‐treatment LDL‐C levels were 107.8 ± 41.5, 84.4 ± 40.9, and 85.8 ± 32.3 (P < 0.0001) and a target of ≤70 mg/dL was reached in 10.9%, 30.0%, and 22.0% (P < 0.0001) of patents with definite/probable, possible FH, and unlikely FH, respectively. Statin therapy was prescribed in 85 (92.4%) patients with definite/probable FH, in 38 (95.0%) with possible FH, and in 3621 (92.9%) with unlikely FH (P = 0.86). The association of statin and ezetimibe, in absence of other lipid‐lowering therapy, was more frequently used in patients with definite/probable FH compared to patients without FH (31.5% vs 17.5% vs 9.5%; P < 0.0001).

Conclusions

In this large cohort of consecutive patients with stable CAD, FH was highly prevalent and generally undertreated with lipid lowering therapies.
Oral Bioavailability and Pharmacokinetics of Nonanimal Chondroitin Sulfate and Its Constituents in Healthy Male Volunteers
Authors: Volpi Nicola , Mantovani Veronica , Galeotti Fabio , Bianchi Davide , Straniero Valentina , Valoti Ermanno , Miraglia Niccolò
Published: July 2018

The pharmacokinetic profile of a new 800‐mg tablet of nonanimal chondroitin sulfate (CS) (Mythocondro®, 800‐mg tablets, Gnosis S.p.A., Italy) was investigated vs an animal CS in healthy volunteers for a total period of 48 hours. After a single 2400‐mg dose of the test and the reference formulation, total CS, the compositional disaccharides (ΔDi6S, ΔDi4S and ΔDi0S), and the overall charge density were quantified in plasma. The safety and tolerability profile after a single dose of this new nonanimal CS tablets was excellent. After baseline‐corrected concentrations, an overall greater plasma concentration was observed after 24 hours of ∼44% and after 48 hours of ∼45% from administration of nonanimal when compared to animal‐derived CS. Moreover, nonanimal CS increases the specific sulfation in the 6‐position of N‐acetyl‐galactosamine in human plasma CS and, as a consequence, the overall charge density, reaching double values (0.91), after 48 hours compared to bovine CS and to endogenous CS. In conclusion, nonanimal CS, possessing a lower molecular weight than an animal‐derived sample, produces a greater CS concentration for a more prolonged period of time in plasma and an increase in charge density and specific 6‐sulfation of endogenous plasma CS.