Factors associated with carotid intima-media thickness progression in patients with asymptomatic hyperuricemia: insights from the PRIZE study
Authors: Saito Yuichi , Tanaka Atsushi , Ishizu Tomoko , Yoshida Hisako , Kubota Yoshiaki , Nanasato Mamoru , Matsuhisa Munehide , Ohya Yusuke , Kobayashi Yoshio , Node Koichi ,   the PRIZE Study Investigators,   Principal Investigator,   PRIZE Steering Committee, Murohara Toyoaki , Inoue Teruo , Sata Masataka , Ohishi Mitsuru ,   PRIZE Executive Committee, Yokote Kotaro , Kario Kazuomi , Watada Hirotaka , Shimomura Iichiro , Matsuhisa Munehide , Fukumoto Yoshihiro , Maemura Koji , Ohya Yusuke ,   PRIZE Site Investigators, Akasaki Yuichi , Ako Junya , Amano Hirohisa , Aonuma Kazutaka , Aoyama Yutaka , Arai Hirofumi , Asai Kuniya , Asaka Machiko , Awaji Yoshifumi , Ban Noriko , Ban Toshiaki , Bando Yasuko K. , Daida Hiroyuki , Eguchi Shunsuke , Enomoto Mami , Fujii Yuichi , Fujikake Akinori , Fujimoto Masanori , Fujisaka Tomohiro , Fujita Shuichi , Fukae Satoki , Fukuda Daiju , Fukui Mieko , Goriki Yuhei , Hamasaki Shuichi , Hara Tomoya , Hasegawa Hiroshi , Hashimoto Kenichi , Hata Mitsumasa , Hata Shiro , Hayashida Ryo , Higashi Akihiro , Higuchi Seiichiro , Honda Akihiro , Hoshide Satoshi , Hoshiga Masaaki , Hotchi Junko , Igata Sachiyo , Ikehara Yumi , Inoue Teruo , Inoue Youhei , Ishigami Hiroko , Ishihara Masaharu , Ishii Hideki , Ishikawa Tetsuya , Ishimatsu Takashi , Ishiyama Yusuke , Ito Takahide , Ito Ayumi , Kadokami Toshiaki , Kamiya Haruo , Kashihara Soichiro , Kawamura Yoshihiro , Kitagawa Kazuo , Kobayashi Yoshio , Kodera Satoshi , Koga Seiji , Koide Hisashi , Koide Yuji , Koiwaya Hiroshi , Kojima Hiroki , Komai Eri , Komatsu Takaaki , Kono Shingo , Kono Takashi , Kubota Yoshiaki , Kuroda Akio , Kuroyanagi Takanori , Kushiyama Akifumi , Kusunose Kenya , Maruhashi Tatsuya , Matsunaga Kazuo , Matsuura Tomomi , Mayama Takafumi , Mine Daigo , Miyamura Masatoshi , Morimoto Ryota , Morita Hideaki , Nagano Hidekazu , Nakagawa Hidemitsu , Nakamura Katsunori , Nakamura Ryo , Nakamura Ikuko , Nakashima Hitoshi , Nanasato Mamoru , Nishi Isao , Niwano Shinichi , Nomura Shuichi , Oda Nozomu , Oguchi Shio , Oguri Mitsutoshi , Okahara Arihide , Okutsu Masaaki , Ozaki Fumitake , Ozeki Michishige , Saisu Tomoko , Saito Yuichi , Saitoh Makoto , Saka Yosuke , Sakai Yoshihiko , Sakane Kazushi , Sakuma Ikki , Sandeep Shakya , Sano Hiroaki , Sekino Hisakuni , Senoo Yuka , Shibata Kensaku , Shibata Yoshisato , Shibata Takahisa , Shiga Akina , Shiina Kazuki , Shimabukuro Michio , Shimbo Yusaku , Shimizu Wataru , Shimpo Masahisa , Soeki Takeshi , Sohmiya Koichi , Suzuki Hiroyuki , Suzuki Susumu , Suzuki Makoto , Tahara Nobuhiro , Tahara Tazu , Takahashi Sadako , Takase Bonpei , Takegami Kaoru , Takiguchi Tomoko , Takikawa Tomonobu , Tamura Ai , Tanaka Tomoaki , Tanaka Akihito , Tanaka Hiroyuki , Tanigawa Jun , Tanimura Daisuke , Tatami Yosuke , Terano Takashi , Terasaki Fumio , Tobushi Tomoyuki , Tokoi Seiko , Tsubouchi Toshiyuki , Uchida Daigaku , Ueda Tomohiro , Ueno Rie , Ueno Hiromi , Ueyama Chikara , Wakatsuki Tetsuzo , Watanabe Tomohiko , Watarai Masato , Yaguchi Isao , Yajima Ayumu , Yamada Jiko , Yamamoto Kyohei , Yamauchi Sachiko , Yamauchi Yohei , Yokota Naoto , Yoshida Tomohiko , Yoshioka Goro ,   Members of the Data and Safety Monitoring Board, Daida Hiroyuki , Ako Junya , Kitagawa Kazuo ,   Members of the Clinical Events Committee, Shimizu Wataru , Kobayashi Yoshio , Ishihara Masaharu ,   Imaging Core Laboratory,   Tsukuba Echo Core Laboratory. LLC, Ishizu Tomoko ,   Monitoring, Ueda Shinichiro ,   Audit Team,   Clinical Research Support Center, University of the Ryukyus,   Trial Secretariat, Tanaka Atsushi , Oyama Jun-ichi , Kagiyama Mikiko ,   Nouvelle Place Inc.,   Organization for Clinical Medicine Promotion
Published: July 2023

Hyperuricemia is reportedly associated with the progression of carotid intima-media thickness (IMT), a surrogate of cardiovascular risks and events. However, factors associated with carotid IMT progression in patients with asymptomatic hyperuricemia are largely unknown. In this post-hoc analysis of the multicenter, randomized PRIZE study, we analyzed data from a total of 326 patients who underwent carotid ultrasonography in a blind manner at baseline and 24 months to evaluate carotid IMT. Mean and maximum IMT at the common carotid artery (CCA) were measured at a central core laboratory. Factors related to the absolute change in mean and maximum IMT from baseline to 24 months were explored. Overall, the adjusted mean [0.0032 (− 0.0214 to 0.0278) mm] and maximum [0.0011 (− 0.0327 to 0.0351) mm] CCA-IMT increased numerically from baseline to 24 months. Multivariable analysis identified higher body mass index, history of atherosclerotic cardiovascular disease (ASCVD), and lower mean CCA-IMT at baseline as significant factors associated with the increase in mean CCA-IMT. In addition, older age and lower mean CCA-IMT at baseline were significant factors for an increased absolute change in the maximum CCA-IMT at 24 months. The present sub-analysis of the PRIZE study showed higher body mass index, history of ASCVD, and older age as significant factors associated with CCA-IMT progression in patients with asymptomatic hyperuricemia. These factors may be considered when identifying the possible risk of atherosclerotic progression in this specific patient population of hyperuricemia.

Trial registration: UMIN000012911 and UMIN000041322.