bluuebunny/crossref_metadata_2025 huggingface dataset:
浅谈建筑施工安全技术与防护措施
Authors: 应海 郭
Published: April 2019

在我国建筑行业飞速发展的今天，建筑施工安全逐渐成为了人们关注的重点话题。对于建筑工程而言，良好的施工安全技术与防护措施必不可少，它直接影响着建筑从业人员的生命安全，是建筑人员安心展开工作的保障。建筑企业应当引入先进的安全技术，并且将防护措施落实在工作中。本文将对建筑施工安全技术与防护措施展开进一步探讨。
Exploring major roadblocks on inclusive education of Syrian refugees in school settings
Authors: KAYSILI Ahmet , Soylu Ayşe , SEVER Mustafa
Published: April 2019

There have been
thousands of Syrian kids studying at Turkish public schools since the beginning
of Syrian migration. This study aims to reveal the social and cultural
motivations causing the barriers in front of inclusive education of Syrian
refugees within school environments. This qualitative research was designed as
a case study. Accordingly, the study group of the research is composed of 12
teachers and 5 administrators from five schools having Syrian refugee students
and 10 parents consisting of both Syrian and Turkish kids. The data was
gathered through semi-structured interviews. At the end of the data analysis,
four main themes were found as: “Language Diversity”, “Reflections of Major
Social Problems in Schools”, “The Dilemmas Based upon Integration Policies” and
“Mutual Roots as an Inclusion Area”. Results of this study show that a
collective and holistic approach is necessary to overcome the barriers in front
of inclusive education of Syrian refugees.
The political is personal: Brexit and the career aspirations of UK undergraduates
Authors: McCrory Marjorie , Thomson Theresa
Published: April 2019

Findings from a small-scale qualitative research project exploring the impact of Brexit on the career aspirations of final year students at a UK university reveal the centrality of values and emotion in career decision-making. Although not conclusive or generalisable, these findings nevertheless demonstrate the impact of the wider context of the world we live in, and specifically, of political events, on perceptions of career and potential career choice. This presents a challenge to career development theorists and practitioners alike to adequately address and respond to the impact of the political in relation to career decision-making.
‘There’s no going back’: The transformation of HE careers services using big data
Authors: Cobb Fiona
Published: April 2019

The capacity for UK Higher Education (HE) careers and employability services to collect and analyse career thinking and employability enhancing experience data – Careers Registration data - has provided unprecedented insight into levels of student career planning, (work) experience gained, and sectors of interest. This article draws on the research findings from the Careers Registration learning gain pilot project, to identify the ways in which careers and employability delivery has fundamentally changed since the introduction of Careers Registration, and considers the impact of big data for the future of HE careers and employability delivery.
‘Um, err, ahh…’ Careers practitioners’ perceptions of weight: A thematic analysis
Authors: Holden Corinne , Van Nieuwerburgh Christian , Yates Julia
Published: April 2019

With 61% of the UK population being overweight, it is likely that career professionals will encounter overweight clients. Even though being overweight is thought to be potentially detrimental to career development, there is little theory or advice to help career practitioners have productive conversations about the issue. This paper reports the findings of a small-scale qualitative study exploring the experiences of six career coaches discussing issues of weight with clients. Results show participants felt deeply uncomfortable with the topic, and were ambivalent about the appropriateness of discussing it within career conversations, despite acknowledging that being overweight can impact negatively on employment.
Who is supporting the career development of refugees? The role of grassroots organisations
Authors: Frigerio Gill , Nasimi Rabia
Published: April 2019

This article uses a case study approach to explore issues in career development provision for resettled refugees in the UK, with particularly reference to the role of grassroots organisations in meeting such needs. Using the Afghanistan and Central Asian Association as a case study, we shed light on the way voluntary organisations support their users in accessing employment, as well as other components of career development. Possible ways for such organisations to complement the work of public employment services with culturally tailored approaches are considered and issues arising identified.
The career development of gay men, lesbians and bisexuals
Authors: Hancock Adrian
Published: April 2019

The career development of lesbian, gay and bisexual people is under-researched, especially in the UK. In this paper I begin by attempting to quantify and describe this group of people before exploring how LGB young people develop an identity in a heteronormative, and often oppressive, environment. I then provide a partial overview of the (mostly American) literature regarding LGB careers, including why and how LGB people choose certain occupations and the largely stereotyped nature of those decisions. I also explore how being LGB affects people at work. Finally, I offer some suggestions for career guidance practice with LGB individuals.
DSM-5 en pacientes que solicitan el primer tratamiento del trastorno por uso de alcohol. Diferencias de sexo en el estudio multicéntrico CohRTA
Authors: Sanvisens Arantza , Zuluaga Paola , Rubio Gabriel , Short Antoni , Gual Antoni , Álvarez Francisco Javier , Torrens Marta , Rodríguez de Fonseca Fernando , Muga Bustamante Roberto , Estudio CohRTA Estudio CohRTA
Published: April 2019

Objetivo: Analizar las diferencias de sexo en los criterios diagnósticos del DSM-5 de los pacientes que solicitan un tratamiento para el trastorno por uso de alcohol (TUA) por primera vez. Métodos: Pacientes incluidos entre enero 2014 y marzo 2016 en el estudio multicéntrico CohRTA de la Red de Trastornos Adictivos. El diagnóstico del TUA se realizó mediante el DSM-5. Además, se recogieron datos sociodemográficos, sobre el consumo de alcohol y otras sustancias, variables clínicas y una analítica general. Resultados: se incluyeron 313 pacientes (74,8% hombres); la edad al inicio del primer tratamiento fue de 48,8 años (desviación estándar (DE): 9,9 años), la edad al inicio del consumo de alcohol de 15,9 años (DE: 3,3 años) y la de inicio del consumo regular de 25,6 años (DE: 9,6 años). Un 69,3% de los pacientes eran fumadores y un 61% tenían antecedentes familiares de TUA. Un 7,7% eran consumidores de cocaína y un 18,2% de cannabis. Las mujeres iniciaron el consumo regular de alcohol más tarde que los hombres (p<,001) y usaban benzodiacepinas con mayor frecuencia (p=,013). Según el DSM-5, el 89,5% de los pacientes presentaban un TUA grave (≥6 criterios). En el análisis ajustado (regresión logística), los hombres tenían mayor probabilidad de presentar el criterio diagnóstico relacionado con el incumplimiento de los deberes fundamentales en el trabajo o en el hogar (OR=1,92, IC95%: 1,06-3,48) y el criterio diagnóstico de consumir alcohol en situaciones de riesgo físico (OR=3,00, IC95%: 1,65-5,46). Discusión: El DSM-5 detecta diferencias de sexo en pacientes que solicitan el primer tratamiento del TUA. El deterioro social y el consumo de alcohol de riesgo son significativamente más frecuentes en hombres.
Detección de la intoxicación por cannabinoides sintéticos en Urgencias: cuando las pruebas toxicológicas rutinarias no bastan
Authors: Dal Santo Francesco , Velasco Ángela , De la Fuente-Tomás Lorena , González-Blanco Leticia , Rodríguez-Revuelta Julia
Published: April 2019

Carta al Editor.
Consumo de cannabis y alteraciones cognitivas en esquizofrenia y primeros episodios psicóticos
Authors: García Álvarez Leticia , Gomar Jesus J. , García-Portilla Mª Paz , Bobes Julio
Published: April 2019

Editorial del vol. 31, nº 2.
Media and Preschool Children
Authors: Rek Mateja , Kovačič Andrej
Published: April 2019

The authors conducted a survey with a nationally representative sample of Slovene parents of 1- to 6-year-old children, collecting parental opinions about their and their children’s media habits. The survey also collected the data about parents’ behaviour in terms of educating their children about the media as well as the data regarding parents’ opinions about positive and negative effects of the media on their children. The authors established that role modelling is crucial in developing children’s media habits. Statistically, parents’ own media habits significantly affect media exposure of their children and their opinion about what an appropriate daily screen limit for their children is. The extent to which parents are exposed to the media as well as the level of their formal education have a statistically significant impact on parents’ behaviour in terms of educating their children about the media and on their opinion about the influence of the media on their children.
Light-Induced Stress as a Primary Evolutionary Driver of Eye Origins
Authors: Swafford Andrew J. M. , Oakley Todd H.
Published: April 2019

Eyes are quintessential complex traits and our understanding of their evolution guides understanding of trait evolution in general. A long-standing account of eye evolution argues natural selection favors morphological variations that allow increased functionality for sensing light (Darwin 1859; v. Salvini-Plawen and Mayr 1977; Nilsson and Pelger 1994; Nilsson 2013). While certainly true in part, this focus on visual performance does not entirely explain why diffuse photosensitivity persists even after eyes evolve, or why eyes evolved many times, each time using similar building blocks. Here we briefly review a vast literature indicating most genetic components of eyes historically responded to stress caused directly by light, including UV damage of DNA, oxidative stress, and production of aldehydes. We propose light-induced stress had a direct and prominent role in the evolution of eyes by bringing together genes to repair and prevent damage from light-stress, both before and during the evolution of eyes themselves. Stress-repair and stress-prevention genes were perhaps originally deployed as plastic responses to light and/or as beneficial mutations genetically driving expression where light was prominent. These stress-response genes sense, shield, and refract light but only under UV exposure. Once under regulatory-genetic control, they could be expressed before UV stress appeared, evolve as a single unit, and be influenced by natural selection to increase functionality for sensing light, ultimately leading to complex eyes and behaviors. Recognizing the potentially prominent role of stress in eye evolution invites discussions of plasticity and assimilation and provides a hypothesis for why similar genes are repeatedly used in convergent eyes. Broadening the drivers of eye evolution encourages consideration of multi-faceted mechanisms of plasticity/assimilation and mutation/selection for complex novelties and innovations in general.
Humic Carbon to Fix Food, Climate and Health
Authors: Blakemore Robert
Published: April 2019

Shutdown for just six days enables land plants to entirely fix CO2 excess of +4 Gt C per yr. Rebuilding soil organic carbon (SOC) in worm-worked humus is the only practical carbon capture and storage (CCS) capable of freely offsetting annual anthropogenic emissions. A case is made to redirect all available resources towards proven, earthworm-based, organic husbandry. Priority is to safely combat mounting global threats due to irreversible species extinction, perilous climate change and deteriorating human wellbeing (mental/physical health). All three interlinked risks are underpinned by a relentless, yet largely ignored, critical loss of precious topsoil. A first step to topsoil recovery is vermi-composting all vegetable and animal ‘wastes’ for return to the field.
Femtosecond laser-processed staining microchip for one-step preparation of fluorescent DNA sample without loss of DNAs
Authors: Jang Yeongseok , Shin Hojun , Jung Jinmu , Oh Jonghyun
Published: April 2019

In this study, we propose a microchip that is sequentially capable of fluorescently staining and washing DNAs. The main advantage of this microchip is that it allows for one-step preparation of small amounts of solution without degrading microscopic bio-objects such as the DNAs, cells, and biomolecules to be stained. The microchip consists of two inlets, the main channel, staining zone, washing zone, and one outlet, and was processed using a femtosecond laser system. High molecular transport of rhodamine B to deionized water was observed in the performance test of the microchip. Results revealed that the one-step procedure of on-chip DNA staining and washing was excellent compared to the conventional staining method. The one-step preparation of stained and washed DNAs through the microchip will be useful for preparing small volumes of experimental samples.
On the taxonomic identities of the names Calandrinia speciosa Lehm. and Calandrinia spectabilis Otto & Dietr. (Montiaceae)
Authors: Hershkovitz Mark
Published: April 2019

Calandrinia speciosa Lehm. and Calandrinia spectabilis Otto & Dietr. are 1830s-vintage validly-published names of Chilean plant species evidently pertaining to taxa currently classified in Cistanthesect. Cistanthe (Montiaceae). The taxonomic status of both names is problematic, because they were not typified or illustrated, their precise Chilean provenance is unknown, and their diagnoses/descriptions might apply to more than one species. Both names have been and continue to be applied taxonomically haphazardly. The existence of two later conceptually heterotypic synonyms of C. speciosa Lehm, viz. C. speciosa Lindl. non Lehm. and C. speciosa Hook. non Lehm., has exacerbated the confusion. The present work summarizes the history of the application of these names in botanical taxonomy and horticulture. Both likely, but not unequivocally, refer to plants of the later-described, typified, and otherwise well-documented species Calandrinia laxiflora Phil. [≡ Cistanthe laxiflora (Phil.) Peralta & D.I. Ford]. But persistent ambiguities justify proposals to reject both C. speciosa and C. spectabilis.
Green-field Architecture for Sustainable Supply Chain Strategy Formulation
Authors: Radanliev Petar
Published: April 2019

The focus of this paper is on supply chain strategy formulation. A conceptual theory approach is used for investigating and identifying the relationship between multiple elements, dimensions, forces and factors that influence and affect the supply chain strategy formulation in Greenfield context, specific to the slate mining industry. The research study involved secondary data review and series of 20 qualitative interviews, followed by 2 group discussions, one with mining and transportation experts external to the supply chain and one group discussion with supply chain internal experts. Through critical analysis, a number of problems emerge and the process of addressing these problems, results in a new framework for evaluating the relationship between business and supply chain strategy, specific to Greenfield project and integration design context.
ICAM3-Fc Outperforms Receptor-Specific Antibodies Targeted Nanoparticles to Dendritic Cells for Cross-Presentation
Authors: Cruz Luis J. , Tacken Paul J. , Schoot Johan S. van der , Rueda Felix , Torensma Ruurd , Figdor Carl G.
Published: April 2019

Abstract Optimal targeting of nanoparticles (NP) to dendritic cells (DCs) receptors to deliver cancer-specific antigens is key to an efficient induction of anti-tumor immune responses. Poly (lactic-co-glycolic acid) (PLGA) nanoparticles containing tètanus toxoid and gp100 melanoma-associated antigen, toll-like receptor adjuvants were targeted to the DC-SIGN receptor in DCs by specific humanized antibodies or by ICAM3-Fc fusion proteins mimicking natural ligand. Despite higher binding and uptake efficacy of anti-DC-SIGN antibody-targeted NP vaccines than ICAM3-Fc ligand, no difference were observed in DC activation markers CD80, CD83, CD86 and CCR7 induced. DCs loaded with NP coated with ICAM3-Fc appeared more potent in activating T cells via cross-presentation than antibody-coated NP vaccines. This fact could be very crucial in the design of new cancer vaccines.
Bir Uzun Hikaye: Cihangir Camii İnşaatı
Authors: TAŞKIN Osman
Published: April 2019

Bu makale Kanuni Sultan Süleyman’ın oğlu Şehzade Cihangir adına
boğaza hâkim bir tepede yaptırdığı Cihangir Camisi’nin sürüncemede kalan yeniden
yapılışına odaklanmıştır. Çalışmada öncelikle caminin gördüğü onarımlar ve
nihayetinde Sultan Abdülaziz’in 1873 yılında başlatıp II. Abdülhamid’in 1890
yılında tamamlatmasına kadar geçen 15 yıl 7 aylık yeniden inşa süreci ele
alınmıştır. Aynı zamanda küçük bir cami inşaatı çerçevesinde Osmanlı
Devleti’nin iktisadi zorluklarına ve izlediği para politikası ile bürokrasinin
hantallığına dair izlenimlere ulaşmak mümkün olmuştur. Sonuç olarak cami
batılılaşma sürecinin okunabildiği bir mimari değişime uğramışsa da XVI.
yüzyılın temel mimari yapısını da muhafaza etmiştir.
A Procedure for Liquid-Assisted Gas Lift Unloading Using a Transient Flow Simulator
Authors: Coutinho Renato P. , Waltrich Paulo J.
Published: April 2019

In this paper we describe using a commercial transient multiphase-flow simulator to develop a new operational procedure for liquid-assisted gas lift (LAGL) unloading. The simulation model is used in our study to perform sensitivity analysis on the controlling parameters for the LAGL unloading operation.

This simulation model is validated with experimental data from field-scale test data presented by Coutinho et al. (2018). From the simulation results and experimental data, it is possible to demonstrate how the injection of a gas/liquid mixture can significantly decrease the injection pressure for unloading operations. Different combinations of injection gas/liquid ratio are numerically tested to evaluate the effect of gas/liquid ratio on the injection pressure during the complete unloading operation.

The validated model was used with a newly developed procedure for the complete unloading operation. The modeling results show that using the LAGL technique enabled us to reduce the injection pressure from 1,200 psig, when using single-phase gas in a single-point injection system, to approximately 700 psig, when injecting gas/liquid mixtures in a single-point injection system. Analyses on the effect of gas lift valve-orifice size, also presented here, show that using large orifice sizes might reduce the effect of flow friction through the gas lift valve, which directly affects the efficiency of the LAGL unloading operations.
Hydrological alteration of the upper Yangtze River and its possible links with large-scale climate indices
Authors: Dong Qianjin , Fang Debin , Zuo Jian , Wang Yongqiang
Published: April 2019

The relationship between hydrological alteration and climate variability in the upper Yangtze River is not fully understood. In this paper, the periodicity features and the intercorrelation of annual and seasonal eco-flow metrics at the Yichang gauge station are analyzed for the period 1882 to 2013. Analysis is carried out to explore the formation of the eco-flow metrics and the possible linkages between eco-flow metrics and selected climate indices, using the cross-wavelet and wavelet coherence methods on data from 1948 to 2013. The results show that the variation of eco-flow metrics correlates well with some selected climate indices, but changes in different eco-flow metrics are complex. Most annual and seasonal eco-flow metrics correlate well with the Northern Hemisphere (N.H) and Indian Ocean Dipole (IOD) and have a significant common power in the two to four years band. In addition, most annual eco-flow metrics have an obvious phase relationship with the selected climate indices. However, the seasonal eco-flow metrics have no significant phase relationship with the selected climate indices. These findings provide a better understanding of how hydrological alterations of the streamflow and better water resource management can ensure ecosystem sustainability for the Yangtze River.
Biodegradation of ametryn and dicamba in a sequential anaerobic-aerobic batch reactor: A case study
Authors: Mahesh Gajanuru Basappa , Manu Basavaraju
Published: April 2019

Agricultural runoff often contains persistent halogenated herbicide compounds like 2-(ethylamino)-4-(isopropylamino)-6-(methylthio)-s-triazine (ametryn) and 3,6-dichloro-2-methoxybenzoic acid (dicamba). These can enter the food chain through drinking water, causing serious effects for people and the environment. A sequential anaerobic reactor followed by an aerobic reactor was operated and investigated for herbicide removal efficiency at constant, three-day, hydraulic retention time (HRT) and organic loading rate (OLR) of 0.2025 kg-COD/m3/d. The effect of the herbicides on anaerobic bacteria was evaluated based on total biogas production and bacterial activity, which indicated that there was no inhibition on the acclimated biomass. The sequential reactor pair removed 72% of ametryn and 78% dicamba, with COD removal efficiencies of 86% and 85% respectively. The different high-performance liquid chromatography (HPLC) peaks indicate that the compounds are biotransformed and this was confirmed by gas chromatograph high resolution mass spectrometry (GC-HRMS).
Enhanced visible light photocatalytic activity of AgI/TiO2 composite fabricated by a grinding method
Authors: Xu Jin , Gao Dasheng , Cui Shuang , Wang Xiaohua , Liu Ningning
Published: April 2019

Through a simple grinding method, AgI/TiO2 composites were successfully synthesized. The as-prepared AgI/TiO2 composites were used as photocatalysts for Rhodamine B (RhB) degradation under visible light irradiation and exhibited excellent photocatalytic performance. In the presence of composites, almost 100% RhB was decomposed after 60 min. The photocatalytic activity of AgI/TiO2-0.5 composite was optimal, which was 9.5 times higher than that of pristine TiO2, and 15.6 times higher than that of AgI. Moreover, experimental results revealed that the improved photocatalytic activity was not only ascribed to the loading AgI but also resulted from the method that enabled the exposure of more active sites in the composites. In addition, the intimate interfacial contact obtained by this method could also promote the efficient separation of photogenerated electron-hole pairs. Moreover, the possible photocatalytic active species and the stability of the photocatalyst were investigated in detail.
Stress deformed state of a drill string under off-design conditions
Authors: Khakimov A.G. , Sharafutdinov Z.Z
Published: April 2019

The paper gives a methodology for calculating the drill string performance under off-design conditions, including the passage through the interface separating rocks with very different physico-mechanical characteristics, drilling of boulder rocks, and dynamic modes of operation. One of the mechanisms of the destruction of drill string elements and roller cutters is revealed.
Dynamic blocking phenomenon at a flow of stabled highly concentrated W/O emulsions
Authors: Akhmetov A.T. , Glukhov V.V. , Mavletov M.V. , Thelin A.G.
Published: April 2019

There are experimental study of flows of reverse highly concentrated water-oil emulsion in the Hele-Shaw cell and cylindrical tubes of various diameters. There are structures are given from the flat flows and the behaviour of the emulsion in flat and cylindrical systems in a state of ”dynamic blocking“. A mathematical model for its description and a comparison with experimental data is offered.
Primera época - Año VII, Número 21-22, mayo 2005
Authors: De San Luis Revista de El Colegio
Published: April 2019

Este número corresponde a la primera época de la Revista de El Colegio de San Luis, denominado VETAS.
Literatura y prensa periódica mexicana. Siglos XIX y XX. Afinidades, simpatías, complicidades
Authors: Sánchez Lárraga Andrea Margarita
Published: April 2019

Los estudios literarios sobre prensa periódica han aumentado en los ultimos años, tal es el caso del libro coordinado por Marco Chavarín e Yliana Rodríguez, Literatura y prensa periódica mexicana. Siglos XIX y XX. Afinidades, simpatías, complicidades. En esta reseña se ofrece un panorama general de los artículos que componen la publicación.
Las comunidades de la Sierra Norte de Puebla, México, frente a los megaproyectos de minería
Authors: Bastidas Orrego Lina María , Cesín Vargas Alfredo , Ramírez Valverde Benito , Juárez Sánchez José Pedro , Martínez Carrera Daniel , Vaquera Huerta Humberto
Published: April 2019

Este trabajo tiene por objetivo analizar las opiniones de los habitantes de las comunidades de estudio acerca del posible desarrollo de la minería en su región y las percepciones sobre este tema. Para ello se elaboró un estudio descriptivo de corte transversal, bajo una metodología de variables cualitativas y cuantitativas; adicionalmente se emplearon fuentes primarias, con instrumentos como encuestas y entrevistas, para obtener datos socioeconómicos de las familias, las opiniones de estas y la perspectiva de la población frente a los proyectos de explotación minera de oro y sus posibles impactos, las estrategias de lucha de las comunidades y las estrategias diseñadas por las empresas mineras. Se encontró que la mayoría de la población en as comunidades de Santa María de Zotoltepec, Tuligtic, La Cañada y Tetela de Ocampo Centro rechaza la minería a cielo abierto y su percepción es negativa acerca de los impactos que tendría la explotación minera; además, se siente vulnerable frente a los proyectos mineros y al gobierno.
Comercio y circulación de libros en Nueva España. Dos autos de la Inquisición de México (1757 y 1802)
Authors: Arteaga Martínez Alejandro
Published: April 2019

Reseña sobre el volumen de Olivia Moreno Gamboa y Óscar Admín Reyes Ruiz, Comercio y circulación de libros en Nueva España. Dos autos de la Inquisición de México (1757 y 1802), que forma parte de la nueva colección sobre historia del libro "Domus Libri". Presenta dos expedientes inquisitoriales del siglo XVIII.
Turismo cultural y peregrino. Producciones de pasado en Real de Catorce
Authors: Álvarez Irene
Published: April 2019

El artículo se propone contrastar las nociones de patrimonio movilizadas por agencias federales dedicadas a la protección y promoción de centros históricos con las concepciones en torno al valor generadas por actores locales en el marco de una peregrinación religiosa. Comprender el patrimonio como producción del valor, y no como una cualidad intrínseca de los objetos, permite analizar una peregrinación religiosa como una práctica patrimonial, en tanto que vincula a los habitantes y visitantes del santuario con sus ancestros. Del análisis de los resultados del trabajo etnográfico se concluye que la peregrinación católica al santuario de Real de Catorce, en San Luis Potosí, México, es una forma de preservar el vínculo con un territorio que tiene una fuerte tradición migratoria. La investigación ofrece una aproximación analítica novedosa al estudio del turismo peregrino y el turismo cultural a través de fuentes primarias.
The Computational Models of Drug-target Interaction Prediction
Authors: Ding Yijie , Tang Jijun , Guo Fei
Published: April 2019

:

The identification of Drug-Target Interactions (DTIs) is an important process in drug discovery and medical research. However, the tradition experimental methods for DTIs identification are still time consuming, extremely expensive and challenging. In the past ten years, various computational methods have been developed to identify potential DTIs. In this paper, the identification methods of DTIs are summarized. What's more, several state-of-the-art computational methods are mainly introduced, containing network-based method and machine learning-based method. In particular, for machine learning-based methods, including the supervised and semisupervised models, have essential differences in the approach of negative samples. Although these effective computational models in identification of DTIs have achieved significant improvements, network-based and machine learning-based methods have their disadvantages, respectively. These computational methods are evaluated on four benchmark data sets via values of Area Under the Precision Recall curve (AUPR).
Recent Advances of Computational Methods for Identifying Bacteriophage Virion Proteins
Authors: Chen Wei , Nie Fulei , Ding Hui
Published: April 2019

Phage Virion Proteins (PVP) are essential materials of bacteriophage, which participate in a series of biological processes. Accurate identification of phage virion proteins is helpful to understand the mechanism of interaction between the phage and its host bacteria. Since experimental method is labor intensive and time-consuming, in the past few years, many computational approaches have been proposed to identify phage virion proteins. In order to facilitate researchers to select appropriate methods, it is necessary to give a comprehensive review and comparison on existing computational methods on identifying phage virion proteins. In this review, we summarized the existing computational methods for identifying phage virion proteins and also assessed their performances on an independent dataset. Finally, challenges and future perspectives for identifying phage virion proteins were presented. Taken together, we hope that this review could provide clues to researches on the study of phage virion proteins.
Preventive Role of Resveratrol Against Inflammatory Cytokines and Related Diseases
Authors: Rafe Tanzir , Shawon Parvez Ahmed , Salem Liyad , Chowdhury Nafij Imtiyaj , Kabir Farjana , Bin Zahur Shah Mehedi , Akhter Rowshon , Noor Humaira Binte , Mohib Md Mohabbulla , Sagor Md. Abu Taher
Published: April 2019

Background:

Immunity is the ultimate barrier between foreign stimuli and a host cell. Unwanted immune responses can threaten the host cells and may eventually damage a vital organ. Overproduction of inflammatory cytokines may also lead to autoimmune diseases. Inflammatory cells and pro-inflammatory cytokines can eventually progress to renal, cardiac, brain, hepatic, pancreatic and ocular inflammation that can result in severe damage in the long run. Evidence also suggests that inflammation may lead to atherosclerosis, Alzheimer’s, hypertension, stroke, cysts and cancers.

Methods:

This study was designed to correlate the possible molecular mechanisms for inflammatory diseases and prevent biochemical changes owing to inflammatory cytokines by using Resveratrol. Therefore, we searched and accumulated very recent literature on inflammatory disorders and Resveratrol. We scoured PubMed, Scopus, Science Direct, PLoS One and Google Scholar to gather papers and related information.

Results:

Reports show that inflammatory diseases are very complex, as multiple cascade systems are involved; therefore, they are quite difficult to cure. However, our literature search also correlates some possible molecular interactions by which inflammation can be prevented. We noticed that Resveratrol is a potent lead component and has multiple activities against harmful inflammatory cytokines and related microRNA. Our study also suggests that the anti-inflammatory properties of Resveratrol have been highly studied on animal models, cell lines and human subjects and proven to be very effective in reducing inflammatory cell production and pro-inflammatory cytokine accumulation. Our tables and figures also demonstrate recent findings and possible preventive activities to minimize inflammatory diseases.

Conclusion:

This study would outline the role of harmful inflammatory cytokines as well as how they accelerate pathophysiology and progress to an inflammatory disorder. Therefore, this study might show a potential therapeutic value of using Resveratrol by health professionals in preventing inflammatory disorders.
Therapeutic Effect of Novel Antidepressant Drugs Acting at Specific Receptors of Neurotransmitters and Neuropeptides
Authors: Werner Felix-Martin , Coveñas Rafael
Published: April 2019

Background:

Major depression is a frequent psychiatric disease. One- third of the depressive patients
remain treatment-resistant; thus, it is urgent to find novel antidepressant drugs.

Objective:

In major depression, in several brain areas the neural networks involved and the alterations of neurotransmitters
and neuropeptides are updated. According to these networks, new pharmacological agents and effective
combinations of antidepressant drugs achieving a more efficacious antidepressant treatment are suggested.

Results:

In the neural networks, the prefrontal cortex has been included. In this brain area, glutamatergic neurons,
which receive an activating potential from D2 dopaminergic neurons, presynaptically inhibit M1 muscarinic cholinergic
neurons via NMDA receptors. Medium spiny GABAergic/somatostatin neurons, which receive projections
from M1 muscarinic cholinergic neurons, presynaptically inhibit D2 dopaminergic neurons via
GABAA/somatostatin1 receptors. The combination of an NMDA receptor antagonist with an M1 muscarinic cholinergic
receptor antagonist can achive a rapid, long-lasting antidepressant effect.

Conclusion:

In preclinical studies, the antidepressant effect of orvepitant, an NK1 receptor antagonist, has been
demonstrated: this antagonist reaches a complete blockade of NK1 receptors. In clinical studies, the combination
of an NMDA receptor antagonist with an M1 muscarinic cholinergic receptor antagonist should be investigated indepth
as well as the therapeutic effect of orvepitant. In clinical studies, the antidepressant effect of a triple reuptake
inhibitor should be examined and compared to current antidepressant drugs.
Biotechnology of Viscum Album L. and Cancer Treatment: A Review
Authors: Tsekouras Vasileios , Kintzios Spyridon
Published: April 2019

Background:

This review aims to highlight biotechnological techniques applied for the identification,
isolation and propagation of mistletoe-derived bioactive compounds and the preclinical
evaluation of their anticancer properties.

Methods:

We undertook a structured search of bibliographic databases to identify and evaluate the literature,
regarding biotechnology of mistletoe and malignancy treatment. The selected articles were classified
into five modules according to the study design.

Results:

Firstly, we have provided an overview of the role of biotechnology in plant-derived pharmaceuticals,
by reviewing twelve articles. Then, V. album L. botany and a retrospection of the plant pharmaceutical
applications are presented from a set of ten articles. Subsequently, mistletoe derived compounds
and their anticancer properties are highlighted, throughout sixty-two articles, which emphasized
the mechanisms of antitumor action. The next module is referred to as the biosynthesis of mistletoe
bioactive compounds, covering nine cases of ‘in vitro’ propagation and genetic manipulation. Finally,
fourteen assays regarding mistletoe preparations and preclinical testing for chemosensitivity are presented.

Conclusion:

Biotechnology provides essential tools for the identification, production and evaluation of
anticancer compounds derived from Viscum album L. The preclinical studies indicate the potential use
of V. album preparations in chemotherapy but further research is essential for standardizing the therapeutic
benefits of mistletoe compounds in the treatment of malignancies.
Prediction of Customer Plan using Churn Analysis for Telecom Industry
Authors: P. Ajitha , A. Sivasangari , R.M. Gomathi , K. Indira
Published: April 2019

Background:

In creating nations like India, there are in excess of 10 administrators
giving versatile administration in each circle. With the presentation of number convenience portable
client are progressively changing starting with one administrator then onto the next. This conduct
is called beat. The explanation behind beat might be many like valuing isn't alluring, visit call
drops, message drops, more client care calls and so forth. Presently the administrator in INDIA is
aware of the need of client. At that point, it is past the point of no return as the client has officially
settled on choice and hard to persuade and retain. So a robotized instrument is needed at administrator
end to predict which client may beat with high exactness.

Objective:

With fast utilization of outfit classifiers to enhance exactness, we additionally propose
a gathering cross breed classifier that predicts with more precision.

Methods:

Hybrid model contains regression, perceptron and confrontation both regression and
perceptron run parallel after completion execution both the results will be compared in a confrontation
level.

Conclusion:

The report of customer who are predicted to churn and the reason for churning if reported.
Also it will store aggregate reporting HBASE database.
Voluntary defense networks in emergency preparedness in developed countries: the case of Sweden
Authors: Kaneberg Elvira , Hertz Susanne , Jensen Leif-Magnus
Published: April 2019

Voluntary networks are actors in civil society and central to the emergency preparedness efficiency of developed countries’. This study focuses on the voluntary defense networks in Sweden, a unique set of networks that contribute to the efficiency of emergency preparedness. Through interviews with experts in Swedish civil and military fields and their associated voluntary defense networks, as well as secondary data, we examined the coordination of these voluntary defense networks in practice. Although voluntary network coordination is highly associated with efficiency, in practice, most voluntary networks are not well coordinated. This study confirms that civil and military practitioners in developed countries, struggling with the coordination of voluntary networks are not isolated in their struggle; inattentive practices are indeed the norm. This article also establishes a course that civil and military practitioners can follow to improve emergency response efficiency.
Método histórico e inteligencia estratégica en Colombia, 1888-2001
Authors: Esquivel Triana Ricardo
Published: April 2019

El objetivo de este artículo es demostrar la necesidad para Colombia de una inteligenca estratégica basada en el aporte de la disciplina histórica para su análisis. Se asume que historia e inteligencia, en cuanto disciplinas, tienden a ser interdependientes, pues incluso en lo metodológico resultan ampliamente complementarias. El aporte historiográfico para el desarrollo de la inteligencia ha sido significativo, tanto para reconstruir la evolución de esta como para contextualizar la inteligencia estratégica. La falta de esta última en Colombia se explica por la adopción del modelo francés de “alta policía” y por una historiografía que ha propugnado el culto a la formalidad del derecho internacional por parte de los dirigentes colombianos.
Indonesian Adaptation and Psychometric Properties Evaluation of the Big Five Personality Inventory: IPIP-BFM-50
Authors: Akhtar Hanif , Azwar Saifuddin
Published: April 2019

The big five personality traits are the best acknowledged and most commonly used model in psychology. Therefore, many personality scales are developed based on this personality model. IPIP-BFM-50 is one of the open-source scales measuring big five personality that is widely used by the world researchers. This study aimed to adapt IPIP-BFM-50 into Indonesian and evaluate its psychometric properties. Adaptation was done by following the guidelines of the International Test Commission (ITC). The result shows that IPIP-BFM-50 Indonesia has Aiken's V index ranging from 0.71 - 0.98. Alpha reliability with n = 502 ranges from 0.762 (agreeableness) to 0.862 (emotional stability). Factor analysis shows that the items are well-grouped according to their dimensions with loading factor ranging from 0.34 to 0.75 on the factors measured. Thus, IPIP-BFM-50 Indonesia has satisfactory psychometric properties and can be used to measure Big five personality.
Post-Depletion Aggression Restrained: Replicabily of Brief Mindfulness Induction In Indonesian Sample
Authors: Yusainy Cleoputri , Wicaksono Wahyu
Published: April 2019

Mindfulness practice is being promoted in Western countries as a means to improve one’s ability to restrain aggression under “depleted” condition. The applicability of this framework in non-Western settings is yet to be determined. This study (N = 119 Indonesian undergraduates) directly replicated Yusainy and Lawrence (2015) experiment with native British sample, to examine the moderation of mindfulness induction on post-depletion aggression (i.e., blast intensity in an adapted competitive reaction-time task). Similar results were obtained, in that mindfulness induction moderated the ego-depletion and (i) blast intensity link under low/moderate provocation, and (ii) self-control performance link after the aggression task. Notably, the benefit of mindfulness was also indicated in our additional aggression measure of the late deliverance of maximum blast in depleted females. While Western operationalisation of mindfulness operates quite similarly across cultures, the inclusion of a subtle measure of aggression appears to be crucial for Indonesian females.
Design and Simulation of Closed Loop Proportional Integral (PI) Controlled Boost Converter and 3-phase Inverter for Photovoltaic (PV) Applications
Authors: Kadhim Riadh Adnan
Published: April 2019

يتطرق البحث الى تصميم منظومة قدرة شمسية ومحاكاتها مكونة من لوح شمسي نوع KC200GT ، محول Boost ذي دائرة مغلقة وعاكس ثلاثي الطور باستخدام برنامج Matlab/Simulink . تم التطرق الى المعادلات الرياضية الخاصة بتصميم اللوح الشمسي. تم اختبار الخصائص الكهربائية للوح عند القيم 1000 للاشعاع الضوئي و 25 درجة مئوية لدرجة حرارة المحيط . يربط المسيطر PI مع المحول بوصفه دائرة تغذية عكسية للحصول على فولتية خرج مستقرة عن طريق تقليل التذبذبات في الفولتية لشحن بطارية تربط على خرج المحول . تم استخدام طريقتين (Particle Swarm Optimization و ( Zeigler-Nichols لضبط مسيطر PI لغرض تحسين الاداء الكلي للمنظومة. تم استخدام تقنية SPWM للحصول على موجة نقية ثلاثية الطورباقل تشويه ، وتم الحصول على قيم فولتية وتيار خرج المنظومة هي  و  ، و قيمة  ال THD هي  4.20% .
THE POTENCY OF JAVANESE TURMERIC (CURCUMA XANTHORRHIZA ROXB.) ETHANOL EXTRACT TO ERADICATE WILD STRAIN CANDIDA ALBICANS BIOFILM
Authors: LESTARI AYU DIAH , PUSPITAWATI RIA , DJAIS ARIADNA ADISATTYA
Published: April 2019

Objective: The pathogenic yeast Candida albicans forms biofilm to increase its resistance toward antifungal agents. Javanese turmeric is an Indonesianmedicinal plant reported to have antifungal effects due to the active component, xanthorrhizol. The objective of this study was to measure the in vitropotential of Javanese turmeric ethanol extract to eradicate C. albicans biofilm.Methods: C. albicans was exposed to Javanese turmeric ethanol extract for 1 h during biofilm formation phases. MTT assay was used to test thepercentage of biofilm eradication.Results: The minimum inhibitory concentration and minimum fungicidal concentration of Javanese turmeric ethanol extract against planktonicC. albicans were 15%. The minimum biofilm eradication concentration (MBEC50) was 25% in the early phase and 15% in the intermediate andmaturation phases.Conclusions: Javanese turmeric ethanol extract is effective at eradicating clinical isolate of C. albicans biofilm.
POTENTIAL OF JAVANESE TURMERIC ETHANOL EXTRACT IN INHIBITING STREPTOCOCCUS SANGUINIS AND PORPHYROMONAS GINGIVALIS BIOFILM FORMATION
Authors: HUTAURUK REINA , SUNIARTI DEWI FATMA , DJOHAN WIDURINI
Published: April 2019

Objective: The purpose of the current study was to evaluate the potential of Javanese turmeric ethanol extract in the inhibition of the formation ofStreptococcus sanguinis and Porphyromonas gingivalis biofilms, individually and in combination.Methods: The concentration of P. gingivalis and S. sanguinis bacteria ranged from 0.5% to 25%. Inhibition assay for biofilm formation was conductedon a 96-well plate using brain heart infusion (BHI) agar enriched with 0.2% sucrose at 37oC for 18 h. After staining with 0.5% crystal violet, the opticaldensity was measured at 490 nm.Results: Javanese turmeric can potentially inhibit the biofilm formation of S. sanguinis (IC50 0.5%, IC90 15%) and P. gingivalis (IC50 15%) on single anddual species (IC50 0.5%, IC90 15%).Conclusion: Javanese turmeric has the potential to inhibit the formation of S. sanguinis and P. gingivalis biofilms.
CHEWING GUM CONTAINING PROPOLIS WAX FROM APIS MELLIFERA BEES FOR PREVENTION OF DENTAL CARIES DISEASE
Authors: SOEKANTO SRI ANGKY , LEVINA ASTRID , SHARFINA IRIANTO EKA NURIN , ADZIMA ACHMAD HUDA FAUZI , HERMANSYAH HERI , WIJANARKO ANONDHO , SAHLAN MUHAMAD
Published: April 2019

Objective: Dental caries is caused by demineralization of the tooth surface by organic acids as a result of metabolism of cariogenic bacteria, especiallyStreptococcus mutans. Chewing gum has been proven to help prevent dental caries formation by stimulating salivary flow and thus reducing theavailability of nutrients for cariogenic bacteria.Methods: In this study, sugar-free chewing gum was formulated using latex from the jelutong tree (Dyera costuata) with the addition of propolis wax(1–5%) as an antibacterial agent to inhibit the activity of S. mutans and prevent biofilm formation, which is an early disease stage of dental caries.Characterization of jelutong latex using differential scanning calorimetry and thermogravimetric analysis shows that the latex has glass transitiontemperatures of −22.46°C and 33.86°C, and it contains volatile (14.96%), polymer (84.43%), organic (0.36%), and inorganic (0.25%) components.The propolis wax used in this formulation mostly contains resin and wax and is a purification by-product of raw propolis obtained from Apis mellifera.Results: Flavonoids acting as antibacterial compounds are found in propolis, and presumably are also found in propolis wax; thus, probably thiscompound also has the antibacterial properties of propolis. The in vitro testing showed that 5% propolis wax in sugar-free chewing gum can preventthe formation of dental caries by inhibiting biofilm formation with up to 80% more effectiveness relative to negative controls (without chewing gum).Conclusion: Propolis wax chewing gum can inhibit the formation of dental caries disease.
IN VITRO POTENCY AND TOXICITY OF STREPTOMYCES SP. FERMENTATION PRODUCT AS AN ANTIMALARIAL THERAPY AGAINST PLASMODIUM FALCIPARUM
Authors: SETYANINGSIH YUNI , LATIF ABDUL , ASTUTY HENDRI , SYAFRUDDIN DIN , ASIH PUJI BUDI SETIA
Published: April 2019

Objective: This research aims to study the activity of a Streptomyces sp. fermentation product as an antimalarial modality in HepG2 cells.Methods: The effects of the product against Plasmodium falciparum 3D7 were examined using an in vitro technique parasite. The potency of theStreptomyces sp. fermentation product was examined by determining the half maximal inhibitory concentration (IC50), and the mechanism wasstudied using transmission electron microscopy (TEM). Toxicity tests were also conducted.Results: The Streptomyces sp. fermentation product had an IC50 of 0.001 μg/ml against the parasite, versus values of 0.054 and 0.022 μg/ml forquinidine and prodigiosin, respectively. TEM revealed no formation of hemozoin. The Streptomyces sp. fermentation product was non-toxic in HepG2cells based on its cytotoxicity concentration 50% of 1.380 μg/ml.Conclusion: The Streptomyces sp. fermentation product has potential as a potent and non-toxic antimalarial therapy.