bluuebunny/crossref_metadata_2025 huggingface dataset:
IL-13Rα2 Status Predicts GB-13 (IL13.E13K-PE4E) Efficacy in High-Grade Glioma
Authors: Rechberger Julian S. , Porath Kendra A. , Zhang Liang , Nesvick Cody L. , Schrecengost Randy S. , Sarkaria Jann N. , Daniels David J.
Published: April 2022

High-grade gliomas (HGG) are devastating diseases in children and adults. In the pediatric population, diffuse midline gliomas (DMG) harboring H3K27 alterations are the most aggressive primary malignant brain tumors. With no effective therapies available, children typically succumb to disease within one year of diagnosis. In adults, glioblastoma (GBM) remains largely intractable, with a median survival of approximately 14 months despite standard clinical care of radiation and temozolomide. Therefore, effective therapies for these tumors remain one of the most urgent and unmet needs in modern medicine. Interleukin 13 receptor subunit alpha 2 (IL-13Rα2) is a cell-surface transmembrane protein upregulated in many HGGs, including DMG and adult GBM, posing a potentially promising therapeutic target for these tumors. In this study, we investigated the pharmacological effects of GB-13 (also known as IL13.E13K-PE4E), a novel peptide–toxin conjugate that contains a targeting moiety designed to bind IL-13Rα2 with high specificity and a point-mutant cytotoxic domain derived from Pseudomonas exotoxin A. Glioma cell lines demonstrated a spectrum of IL-13Rα2 expression at both the transcript and protein level. Anti-tumor effects of GB-13 strongly correlated with IL-13Rα2 expression and were reflected in apoptosis induction and decreased cell proliferation in vitro. Direct intratumoral administration of GB-13 via convection-enhanced delivery (CED) significantly decreased tumor burden and resulted in prolonged survival in IL-13Rα2-upregulated orthotopic xenograft models of HGG. In summary, administration of GB-13 demonstrated a promising pharmacological response in HGG models both in vitro and in vivo in a manner strongly associated with IL-13Rα2 expression, underscoring the potential of this IL-13Rα2-targeted therapy in a subset of HGG with increased IL-13Rα2 levels.
Polyaphron Formulations Stabilised with Different Water-Soluble Polymers for Ocular Drug Delivery
Authors: Moiseev Roman V. , Steele Fraser , Khutoryanskiy Vitaliy V.
Published: April 2022

As drug delivery to the eye has evolved over the last decades, researchers have explored more effective treatments for ocular diseases. Despite this, delivering drugs to the cornea remains one of the most problematic issues in ophthalmology due to the poor permeability of the cornea and tear clearance mechanisms. In this study, four different types of polyaphron formulations are prepared with 10% poloxamer 188 (P188), 10% poly(2-ethyl-2-oxazoline), 1% polyquaternium 10, and 3% sodium carboxymethylcellulose solutions mixed with 1% Brij® L4 in a caprylic/capric triglycerides solution. Their physicochemical characteristics, rheological properties, and stability are assessed. Additionally, a polyaphron with 3% polyquaternium 10 was prepared for the assessment of ex vivo corneal retention along with four other polyaphrons. The best retention on the ex vivo cornea was displayed by the 3% polyquaternium 10-based formulation. The 10% poloxamer 188 along with 1% polyquaternium 10-based polyaphrons appeared to be the most stable among the four prepared formulations. A toxicological evaluation of these formulations was performed using a slug mucosal irritation test and bovine corneal opacity and permeability assay, with all four polyaphrons proving good biocompatibility with ocular tissues. The developed drug delivery systems demonstrated an excellent potential for ocular drug delivery.
Monoclonal Antibody Functionalized, and L-lysine α-Oxidase Loaded PEGylated-Chitosan Nanoparticle for HER2/Neu Targeted Breast Cancer Therapy
Authors: Saravanakumar Kandasamy , Sathiyaseelan Anbazhagan , Park Soyoung , Kim Song-Rae , Priya Veeraraghavan Vishnu , Wang Myeong-Hyeon
Published: April 2022

Herein, we designed a nanocarrier to deliver the LO specifically to HER2+ breast cancer (BC) cells, where functionalization of mAb (anti-HER2+) with PEGylated chitosan enabled it to target the HER2+ BC cells. Taking advantage of overexpression of HER2+ in cancer cells, our nanocarrier (CS-LO-PEG-HER NPs) exhibited promising potency and selectivity against HER2+ BC cells (BT474). The CS-LO-PEG-HER NPs demonstrated the cytotoxicity in BT474 cells by promoting reactive oxygen species, mitochondrial membrane potential loss, and nucleus damage. The biocompatibility of CS-LO-PEG-HER NPs was evidenced by the hemolysis assay and H & E staining of major organs. The CS-LO-PEG-HER NPs showed anticancer potency against the BT474-xenograft tumor-bearing mice, as evident by the reduction of tumor size and cell density. These results indicate that CS-LO-PEG-HER NPs are biocompatible with mice while inhibiting tumor growth through alter the oxidative stress. Overall, this work provides a promising approach for the delivery of LO for good therapeutic effect in combination with mAb.
Test Methods for Characterizing the Properties of Fiber-Reinforced Polymer Composites at Elevated Temperatures
Authors: Kodur Venkatesh , Venkatachari Svetha , Matsagar Vasant A. , Singh Shamsher Bahadur
Published: April 2022

Recent research trends focus on developing bio-based (derived from agricultural byproducts) fiber-reinforced polymer (FRP) composites for structural applications. Fire resistance is one of the key issues that need to be addressed for the use of these FRP materials in buildings. The thermal and mechanical properties of the constituent materials essentially determine the fire performance (and the fire resistance rating) of a structural member, and these properties vary with temperature. Further, the properties of composite materials such as the FRP are highly influenced by the composition and type of fibers and matrix, and these thermo-mechanical properties also vary significantly with temperature. Due to this variation, the fire resistance of FRP materials (both conventional and bio-based) poses a major concern for use in buildings. Currently, very few standardized test procedures are available for evaluating the high-temperature material properties of FRP composites. In this paper, a review of testing protocols and procedures for undertaking tests on FRP materials at various elevated temperatures for evaluating their properties is carried out. Recommendations are provided on the most suitable test methods, specimen conditions, testing regime, and other issues associated with testing at elevated temperatures. In addition, the applicability of the proposed test methods is illustrated through a case study on conventional FRP specimens. Further, the applicability of the recommended test procedures for measuring high-temperature properties of bio-based FRP composites is highlighted.
Development of Carboxymethyl Chitosan Nanoparticles Prepared by Ultrasound-Assisted Technique for a Clindamycin HCl Carrier
Authors: Chaiwarit Tanpong , Sommano Sarana Rose , Rachtanapun Pornchai , Kantrong Nutthapong , Ruksiriwanich Warintorn , Kumpugdee-Vollrath Mont , Jantrawut Pensak
Published: April 2022

Polymeric nanoparticles are one method to modify the drug release of small hydrophilic molecules. In this study, clindamycin HCl was used as a model drug loaded in carboxymethyl chitosan nanoparticles cross-linked with Ca2+ ions (CMCS-Ca2+). The ultrasonication with experimental design was used to produce CMCS-Ca2+ nanoparticles loading clindamycin HCl. The model showed that the size of nanoparticles decreased when amplitude and time increased. The nanoparticle size of 318.40 ± 7.56 nm, decreased significantly from 543.63 ± 55.07 nm (p < 0.05), was obtained from 75% of amplitude and 180 s of time, which was one of the optimal conditions. The clindamycin loading content in this condition was 34.68 ± 2.54%. The drug content in nanoparticles showed an inverse relationship with the size of the nanoparticles. The sodium carboxymethylcellulose film loading clindamycin HCl nanoparticles exhibited extended release with 69.88 ± 2.03% drug release at 60 min and a gradual increase to 94.99 ± 4.70% at 24 h, and demonstrated good antibacterial activity against S. aureus and C. acne with 40.72 ± 1.23 and 48.70 ± 1.99 mm of the zone of inhibition at 24 h, respectively. Thus, CMCS-Ca2+ nanoparticles produced by the ultrasound-assisted technique could be a potential delivery system to modify the drug release of small hydrophilic antibiotics.
Morocco as a Hub of Globalised Traditional Islam
Authors: Sparkes Jason Idriss
Published: April 2022

Muslims on every continent have responded in a great variety of ways to the challenges of colonial modernity. Yet, it is also possible to examine broader currents within this diversity. Fundamentalism, modernism, and traditionalism are global currents which also overlap with other religions, such as Christianity or Hinduism. However, these contested and unstable categories only loosely designate internally diverse currents comprised of complex sub-currents as well as countercurrents. Fundamentalism, for example, has been used to designate various Wahhabi or Salafi movements. Modernism can refer to liberal, progressive, and even postmodern Islamic movements. Traditionalism generally refers to those movements which claim continuity with classical lineages, especially in jurisprudence (fiqh), doctrine (‘aqîda), and spirituality (tasawwuf). Muslims associated with this current generally identify as Traditional rather than Traditionalist. Traditional Islam is a global community whose participants adhere to several Sunni and Shia lineages and share a common discourse, network, and aesthetics. These participants typically depict fundamentalism as too rigid and literalist, and modernism as too eager to capitulate to Western ideologies and prone to unorthodox interpretations of Islam. However, rather than hostility and conflict with the West, Traditional Muslims tend to promote peaceful inter-civilisational dialogue, based on shared values in terms of spirituality, ethics, and indeed geopolitical stability. Morocco has emerged as a hub of Traditional Islam, along with other countries such as Jordan. It is pursuing an official policy to reinforce its reputation as the centre of a Western Islamic tradition that converges around the following four central elements: (1) veneration of the Prophet Muḥammad’s descendants (sharifism); (2) Maliki fiqh; (3) Ash’ari ‘aqîda; (4) Junaydi tasawwuf. This article examines how Morocco is actively engaged in shaping the regional and global Traditional Islamic community. It also proposes a decolonial world-systems analysis of how Traditional Islamic discourse relates to the lived experiences of Muslims in places such as Morocco. Based on this analysis, this article concludes that a credibility problem impedes efforts by Traditional Muslims to defend the unique ways of being, knowing, and behaving developed by Muslims against the ongoing genocidal threat of colonial modernity.
Urban Sprawl and COVID-19 Impact Analysis by Integrating Deep Learning with Google Earth Engine
Authors: Zarro Chiara , Cerra Daniele , Auer Stefan , Ullo Silvia Liberata , Reinartz Peter
Published: April 2022

Timely information on land use, vegetation coverage, and air and water quality, are crucial for monitoring and managing territories, especially for areas in which there is dynamic urban expansion. However, getting accessible, accurate, and reliable information is not an easy task, since the significant increase in remote sensing data volume poses challenges for the timely processing and analysis of the resulting massive data volume. From this perspective, classical methods for urban monitoring present some limitations and more innovative technologies, such as artificial-intelligence-based algorithms, must be exploited, together with performing cloud platforms and ad hoc pre-processing steps. To this end, this paper presents an approach to the use of cloud-enabled deep-learning technology for urban sprawl detection and monitoring, through the fusion of optical and synthetic aperture radar data, by integrating the Google Earth Engine cloud platform with deep-learning techniques through the use of the open-source TensorFlow library. The model, based on a U-Net architecture, was applied to evaluate urban changes in Phoenix, the second fastest-growing metropolitan area in the United States. The available ancillary information on newly built areas showed good agreement with the produced change detection maps. Moreover, the results were temporally related to the appearance of the SARS-CoV-2 (commonly known as COVID-19) pandemic, showing a decrease in urban expansion during the event. The proposed solution may be employed for the efficient management of dynamic urban areas, providing a decision support system to help policy makers in the measurement of changes in territories and to monitor their impact on phenomena related to urbanization growth and density. The reference data were manually derived by the authors over an area of approximately 216 km2, referring to 2019, based on the visual interpretation of high resolution images, and are openly available.
An Attention Cascade Global–Local Network for Remote Sensing Scene Classification
Authors: Shen Junge , Yu Tianwei , Yang Haopeng , Wang Ruxin , Wang Qi
Published: April 2022

Remote sensing image scene classification is an important task of remote sensing image interpretation, which has recently been well addressed by the convolutional neural network owing to its powerful learning ability. However, due to the multiple types of geographical information and redundant background information of the remote sensing images, most of the CNN-based methods, especially those based on a single CNN model and those ignoring the combination of global and local features, exhibit limited performance on accurate classification. To compensate for such insufficiency, we propose a new dual-model deep feature fusion method based on an attention cascade global–local network (ACGLNet). Specifically, we use two popular CNNs as the feature extractors to extract complementary multiscale features from the input image. Considering the characteristics of the global and local features, the proposed ACGLNet filters the redundant background information from the low-level features through the spatial attention mechanism, followed by which the locally attended features are fused with the high-level features. Then, bilinear fusion is employed to produce the fused representation of the dual model, which is finally fed to the classifier. Through extensive experiments on four public remote sensing scene datasets, including UCM, AID, PatternNet, and OPTIMAL-31, we demonstrate the feasibility of the proposed method and its superiority over the state-of-the-art scene classification methods.
Effect of Feeding Lucerne and a Mixed Diet of Oats and Berseem Clover as a Source of Fresh Forage on Ruminal Characteristics and Nitrogen Use Efficiency in Dairy Cows during the Winter Period
Authors: Enriquez-Hidalgo D. , Barrera K. , Rivero M. J. , Merino V. M. , Teixeira D. L. , Vargas-Bello-Pérez E.
Published: April 2022

The inclusion of fresh forages into dairy cows’ diets during the winter can represent economic and nutritional benefits but can affect cows’ metabolic function. The study aimed to evaluate the effect of using fresh berseem clover/oat (MIX), fresh lucerne (LEG) and hay/silage (CON) as forage basis for total mixed ration during the winter period on dairy cows’ rumen characteristics and N metabolism. Three non-lactating rumen-cannulated cows were allocated to each diet for a 14-day period in a 3 × 3 Latin Square design. Sample collection occurred on the last 3 days of each period. Rumen fluid samples were analysed for pH, volatile fatty acids and N-ammonium contents. In situ forage nutrients degradability were evaluated by ruminal incubation. Serum, urine and faecal samples were collected and analysed for N content. Cows had similar feed intakes. No major changes were observed in rumen characteristics, but LEG led to greater ruminal N-ammonium and ammonium ureic N contents. Fresh pasture diets reduced the daily urine ureic N. The fresh forages improved the ruminal kinetics of dry matter and crude protein. The forage nutrients’ effective degradability was greater for the fresh pasture diets than for CON. Overall, inclusion of fresh forages had minor effects on ruminal parameters, but the use of the MIX diet represents a suitable option in terms of N use efficiency.
Piezoresistive Sensor Based on Micrographite-Glass Thick Films
Authors: Correa Osvaldo , de Abreu Filho Pompeu Pereira , Moshkalev Stanislav , Swart Jacobus
Published: April 2022

A new Pb-free glass containing several oxides (Bi2O3, B2O3, SiO2, Al2O3 and ZnO) with sintering temperature reduced down to 600 °C has been developed for applications in a piezoresistive pressure sensor. Using this low sintering temperature glass, it was possible to fabricate micrographite-based pastes and piezoresistive films without losses of graphitic material during the sintering. Good adherence of the films onto alumina substrates was observed and attributed in part to the reactions of ZnO and Bi2O3 with alumina substrates. Piezoresistive films with uniformly distributed micrographite particles were produced using sodium carboxymethyl cellulose (NaCMC) in aqueous solutions during the preparation of pastes. NaCMC plays a decisive role in interactions between micrographite particles and glassy matrix, providing good wettability of glass powder particles and homogeneous distribution of MG particles in the pastes. Finally, excellent repeatability of the sensor response to the applied deformations was verified in cycling experiments when the sample was submitted to 1000 load/release cycles. These results demonstrated very high stability of the sensor response (within ±1%), and also evidenced high stability of the film under the cyclic strain loads and good film adherence to the substrate.
Study of Model Uncertainties Influence on the Impact Point Dispersion for a Gasodynamicaly Controlled Projectile
Authors: Jacewicz Mariusz , Lichota Piotr , Miedziński Dariusz , Głębocki Robert
Published: April 2022

The article presents the analysis of the impact point dispersion reduction using lateral correction thrusters. Two types of control algorithms are used and four sources of uncertainties are taken into account: aerodynamic parameters, thrust curve, initial conditions and IMU errors. The Monte Carlo approach was used for simulations and Circular Error Probable was used as a measure of dispersion. Generic rocket mathematical and simulation model was created in MATLAB/Simulink 2020b environment. Results show that the use of control algorithms greatly reduces the impact point dispersion.
A Global Scoping Review of the Factors Associated with HIV and Syphilis Co-Infection: Findings from 40 Countries
Authors: Varshney Karan , Ikanovic Alexander , Ghosh Prerana , Shet Pavan , Di Sipio Marcus , Khatri Chirag , Mahmood Malik Quasir
Published: April 2022

Human immunodeficiency virus (HIV)–syphilis co-infection poses a threat to certain populations, and patients may have considerably poorer health outcomes due to these infections. Our objective was therefore to provide a scoping review of the literature regarding the factors associated with HIV–syphilis coinfection. We searched PubMed, Scopus, and Web of Science, and produced a total of 1412 articles. After completing the screening process as per the Preferred Items for Systematic Review and Meta-Analysis extension for Scoping Review (PRISMA-ScR) guidelines, a total of 109 articles were eligible for inclusion. A total of 68,634 co-infected patients were included in our review. Findings from studies across 40 countries demonstrated that males—particularly men who have sex with men—compose the overwhelming majority of co-infected cases. Additional risk factors include a low CD4 cell count, current or past sexually transmitted infections, and a high number of sexual partners. Our findings have important implications in guiding public health programs across the globe that aim to lower the rates of HIV–syphilis co-infection. More research is also needed on the role of educational attainment, comorbidities, and consistent condom usage regarding the risk for co-infection.
Seroprevalence of Hepatitis B and Hepatitis C in Inpatients for Alcohol and Drug Addiction Treatment in the Psychiatry Clinic of a Private Hospital
Authors: MIZRAKÇI Serpil , GUVEN Mukerrem , ALKAN Sevil
Published: April 2022

Aim: Hepatitis B (HBV) and hepatitis C virus (HCV) infections pose a serious health problem in our country as well as all over the world. The main transmission routes of these agents include parenteral contact with infected blood or body fluids (percutaneous injury), sexual transmission, and contact with blood and body fluids of infected people. Accordingly, people with drug abuse are an important risk group for these infections. The number of studies in this field in Turkish context is limited. In this study, we aimed to evaluate the seroprevalence of HBV and HCV in inpatients for alcohol and substance addiction treatment in a private hospital psychiatry clinic.

Materials-Methods: This retrospective study relied on the files of the patients who were hospitalized in the Alcohol and Substance Treatment Clinic in the sense that the results of HBsAg, anti-HBs, and anti-HCV parameters were evaluated retrospectively from the hospital automation system.

Results: Of the 568 patient included in the study, 154 (27.1%) were female, 414 (72.9%) were male, and the mean age was 35 (18-88). Findings revealed that 7 (1.23%) of the patients were positive for HBsAg, 229 (40.4%) for anti-HBs, and 41 (7.21%) for anti-HCV. There was no significant difference between HBsAg and Anti-HCV positivity rates by gender.

Conclusion: In our study, anti-HCV positivity was detected at a very high rate (7.21%). It can be concluded that the evaluation of these people in terms of test accuracy with HCV RNA as well as treating the infections detected in this group with effective new generation antivirals will also be beneficial with respect to reducing the number of people who can transmit the infection.
Calcifying odontogenic cyst associated with complex odontoma treated with a conservative approach: a case report / Cisto odontogênico calcificante associado a odontoma complexo tratado com abordagem conservadora: relato de caso
Authors: Silva Priscila Macêdo França da , Paiva Calebe Lamonier de Oliveira Costa , Bezerra Thâmara Manoela Marinho , Martínez Farah Essguí Orellana , Lopes Timóteo Sousa , Santos Thiago Jonathan Silva dos , Mota Mário Rogério Lima , Pereira Karuza Maria Alves , Soares Eduardo Costa Studart , Alves Ana Paula Negreiros Nunes
Published: April 2022

Calcifying odontogenic cysts (COCs) are uncommon benign lesions arising from the odontogenic epithelium which are currently considered cysts. Histopathologically, it presents as an epithelial lining with ameloblastic characteristics, in addition to ghost cells with tendency to undergo calcifications. The objective of this study was to describe a case of a calcifying odontogenic cyst associated with odontoma, which was treated with a conservative two-step approach. A 29-year-old female presented with increased volume on the right side of the face with a lesion detected at the bottom of the buccal groove, extending from tooth 53 to 16. Radiographically, a wide, unilocular lesion was observed, involving tooth 13 that was impacted. Histopathological examination was consistent with COC associated with complex odontoma. No recurrence was seen at 6-month follow-up. The case addresses the importance of anatomopathological diagnosis of the lesion, since characterization of the cyst is fundamental to treatment
Epidemiological evaluation of notified cases of tuberculosis in Minas Gerais, Brasil / Avaliação epidemiológica de casos notificados de tuberculose em Minas Gerais, Brasil
Authors: Tabai Beatriz Joia , Bispo Danilo Pereira , Ferreira Alícia Caroline Cardoso , Macedo Rogério Fernandes , Ribeiro Ana Alice Pereira , Souza Marcos Junior Oliveira de , Farias Quésia Cristina Soares , Matos Ramana Carvalho
Published: April 2022

Due to the situation of growing poverty in the state of Minas Gerais and the tuberculosis’ severity, a pathology associated with poor living conditions, it is necessary to study the incidence of new cases of this pathology so that public health measures can be taken to revert this scenario. So, the objective of this study is to evaluate the incidence of notified cases of tuberculosis in the state of Minas Gerais between 2015 and 2020. The number of confirmed and notified cases of tuberculosis in the state of Minas Gerais from 2015 to 2020 was collected in the Information System of Notifiable Diseases of the IT department of the Brazilian Unified Health System (DATASUS), through the Tabnet system. Between 2015 and 2020, 24717 new cases of tuberculosis were reported in the Brazilian state of Minas Gerais. Regarding the year, 4053 occurred in 2015, 4071 in 2016, 4055 in 2017, 4214 in 2018, 4349 in 2019 and 3975 in 2020. For all of the foregoing, the great significance and need for attention focused on the prevention and treatment of Tuberculosis is highlighted.
Trends of COVID-19 pediatric admissions number during the first 24 weeks of COVID-19 vaccination in Rio de Janeiro, Brazil / Tendências do número de admissões pediátricas da COVID-19 durante as primeiras 24 semanas de vacinação da COVID-19 no Rio de Janeiro, Brasil
Authors: Silva André Ricardo Araujo da , Esteves Mônica Del Monaco , Carvalho Bernardo Rodrigues Rosa de , Souza Cristina Vieira , Teixeira Cristiane Henriques
Published: April 2022

Objective: To describe trends of COVID-19 pediatric admissions number during the first 24 weeks of COVID-19 vaccination.   Design: A retrospective study was conducted in children (0-18 years), admitted in two pediatric hospitals of Rio de Janeiro city, between January 17 and July 3, 2021 with confirmed COVID-19 by reverse transcription polymerase chain reaction or serological tests. Trends of COVID-19 pediatric admissions number during the first 24 weeks of COVID-19 vaccination in Rio de Janeiro, Brazil and the pre-vaccine period were measured by linear regression. Participants: Children admitted in pediatric hospitals in Rio de Janeiro, city, Brazil Results: The number of total admitted patients (with all diseases) were 5340 during the pre-vaccine period, being 94 (1.8%) of them with confirmed COVID-19, and 4182 children admitted during the vaccine period, with 86 confirmed COVID-19 patients (2.1 %) (p=0.29). Media of cases admitted per/week were 2.02 in pre-vaccine period and 3.6 during the first 24 weeks of COVID vaccination (p=0.009). One death was reported in the pre-vaccine period and four in the vaccine period (p=0.14). Trends of increase in the number of admitted cases were verified both in the pre-vaccine period as in the vaccine period, being more expressive in the last one. Conclusion: There was trend of increase in number of children admitted with confirmed COVID-19 during the first 24 weeks of COVID-vaccination in Rio de Janeiro, city. Considering that few people were fully vaccinated, reducing of number of admitted children with confirmed COVID-19 was not verified.
Vaginal hysterectomy in a 95-year-old woman a case report/ Histerectomia vaginal em mulher de 95 anos relato de caso
Authors: Rogenski Raquel de Moura , Braga João Paulo Costa , Oderich Carolina
Published: April 2022

M.M, 95-year-old Japanese woman, 6 vaginal deliveries, presented a 20 days fetid vaginal smell/5 months mild vaginal bleeding. Well appearing, oriented and coherent. Physically active, having a controlled mild hypertension as the only comorbidity. Vaginal exame, identified a foul smelling from the cervix. A transvaginal ultrasound revealed anteverted/flexed uterus, and the endometrial cavity had cystic/solid content, without vascularity in doppler. Endometrial biopsy was performed and the hypothesis of neoplastic cells was discharged. It was indicated a total vaginal hysterectomy.  There were no complications. The correct anesthetic dose provided lower risk and a better outcome. In the first 12 hours, a pre-renal acute renal failure was reversed. The hospital discharge was after 2 days, when the patient had no pain, was walking and urinating.  Only dipyrone was used as analgesic and 14 days of clindamycin was prescribed. After a month, no complaints/pain were reported. The patient returned to her daily habits and to social contact in a short time, indicating a good evolution. The surgery highly improved the patient’s quality of life.
Approach to Anorexia in Chronic Kidney Disease from Avicenna’s Point of View in Canon of Medicine: A Narrative Review
Authors: Mohajeranirad Maryam , Saeidi Naser , Kamalinejad Mohammad , AlmasiHashiani Amir , Salehi Mehdi , Latifi Seyed Amirhossien
Published: April 2022

Objectives: 35%-50% of patients with chronic kidney disease (CKD) suffer from anorexia, reducing the quality of life and increasing morbidity and mortality. Its causes and definitive treatment are not fully known. In this study, Avicenna’s management in his medical book "Canon of Medicine" was presented to help solve this problem. Materials and Methods: "Loss of appetite" and its MeSH heading term "anorexia," also "chronic kidney disease," were searched in PubMed, Google Scholar, and UpToDate databases. In Iranian traditional medicine, loss of appetite by "Noghsan-e-shahvat-e-taam", renal weakness by "Zafe-e-kolye", and ascites by "Estesgha" were searched in "Canon of Medicine". Results: According to Avicenna and modern medicine, kidneys play an essential role in normal appetite, and both suggest treatment based on the stage of the disease. Avicenna has described the treatment in 4 principles: lifestyle modification, elimination of waste products accumulated in the body, non-oral therapies, and herbal medicine. He processed food in the diets, which reduces their side effects and improves their digestion, and in the studies conducted, it was in line with the nutritional recommendations of modern medicine. Conclusions: Given the importance of anorexia and no known causes and treatment, Avicenna’s perspective can help solve this problem. He has provided various natural, inexpensive, and accessible solutions that can be the basis for future clinical trials.
Genelleştirilmiş Toplamsal Modellerin Zooteknide Kullanımı
Authors: KURDAL Nursen , ÖNDER Hasan
Published: April 2022

Regresyon analizi pek çok bilim dalında olduğu gibi zootekni alanında da en sık kullanılan istatistik yöntemlerden birisidir. Ancak pek çok biyolojik çalışma için doğrusal regresyon varsayımlarının sağlanması mümkün olmamaktadır. Özellikle kesikli verilerin açıklayıcı değişken olarak kullanılması gereken durumlarda doğrusal regresyon kullanılarak elde edilen modellerin istatistiksel olarak hatalı sonuçlar üretebileceği bilinmektedir. Bu gibi durumlar için doğrusal regresyon yerine parametrik olmayan ya da yarı parametrik yöntemlerin kullanılması önerilmektedir. Bu çalışmada, kesikli açıklayıcı değişken varlığında önerilen genelleştirilmiş toplamsal modellerin zootekni alanından elde edilmiş bir veri kümesi kullanılarak tanıtılması amaçlanmıştır. Sonuç değişkeni olarak süt keçilerinden alınan laktasyon süt verimi kullanılırken açıklayıcı değişkenler olarak laktasyon süresi ve ana yaşı kullanılmıştır (n=166). Laktasyon süt verimi, laktasyon süresi ve ana yaşı değişkenlerinin normal dağılış göstermediği belirlenmiştir. Elde edilen doğrusal regresyon modelinin istatistiksel olarak anlamlı olduğu (P0,05) rağmen değişkenlerin normal dağılmadığı bilinmektedir. Bu durumda genelleştirilmiş toplamsal modellerin kullanılmasının önerilebileceği söylenebilir. Sonuç olarak zootekni çalışmalarında kesikli değişkenler ile model oluşturmak gerektiğinde doğrusal modeller yerine genelleştirilmiş toplamsal modellerin kullanılmasının elde edilecek modelin güvenilirliğini artıracağı için önerilebileceği belirlenmiştir.
Pengaruh Inovatif dan Pengetahuan Terhadap Kinerja Pegawai dengan Motivasi Kerja sebagai Variabel Intervening
Authors: Komala Khairat
Published: April 2022

Penelitian ini bertujuan untuk mengetahui seberapa besar Pengaruh inovatif dan pengetahuan terhadap kinerja pegawai dengan motivasi kerja sebagai variabel intervening pada Dinas Tenaga Kerja dan Perindustrian Kota Padang. Populasi dalam penelitian ini adalah pegawai Dinas Tenaga Kerja dan Perindustrian Kota Padang yang berjumlah 53 pegawai. Teknik penarikan sampel adalah total sampel dikarenakan jumlah populasi kurang dari 100 responden sehingga sampel pada penelitian ini adalah seluruh populasi yaitu 53 pegawai. Metode pengumpulan data melalui survei dan menyebarkan kuesioner kepada pegawai sebagai responden. Metode analisis yang digunakan adalah menggunakan SPSS. Hasil penelitian menunjukan variabel inovatif berpengaruh positif dan signifikan terhadap kinerja pegawai, dan berpengaruh positif signifikan terhadap motivasi kerja, kemudian variabel pengetahuan tidak berpengaruh terhadap kinerja pegawai dan motivasi kerja, dan motivasi kerja tidak berpengaruh positif signifikan terhadap kinerja pegawai, kemudian motivasi kerja tidak memediasi hubungan antara inovatif dan pengetahuan terhadap kinerja pegawai.
Gaya Kepemimpinan Transformasional dan Motivasi Kerja terhadap Kinerja Pegawai dengan Organizational Citizenship Behavior sebagai Pemediasi
Authors: Yulita Ellen
Published: April 2022

Penelitian ini bertujuan untuk mengetahui pengaruh gaya kepemimpinan transformational dan motivasi kerja terhadap kinerja pegawai dengan organizatioanal citizenship behaviour sebagai variabel intervening pada Dinas Kearsipan Dan Perpustakaan Kabupaten Pasaman Barat. Metode yang digunakan adalah analisis regresi linier berganda dan analisis jalur. dengan mengedarkan kuesioner sebanyak 64 responden. Hasil diperoleh bahwa terdapat pengaruh positif dan signifikan gaya kepemimpinan transformational terhadap kinerja pegawai pada Dinas Kearsipan Dan Perpustakaan Kabupaten Pasaman Barat. Terdapat pengaruh positif dan signifikan beban kerja terhadap motivasi kerja pada Dinas Kearsipan Dan Perpustakaan Kabupaten Pasaman Barat. Terdapat pengaruh positif dan signifikan gaya kepemimpinan transformational dan motivasi kerja terhadap kinerja pegawai dengan organizatioanal citizenship behaviour pada Dinas Kearsipan Dan Perpustakaan Kabupaten Pasaman Barat. Terdapat pengaruh positif dan signifikan gaya kepemimpinan transformational dan motivasi kerja terhadap kinerja pegawai dengan organizatioanal citizenship behaviour pada Dinas Kearsipan Dan Perpustakaan Kabupaten Pasaman Barat. Terdapat pengaruh positif dan signifikan gaya kepemimpinan transformational dan motivasi kerja terhadap kinerja pegawai dengan organizatioanal citizenship behaviour pada Dinas Kearsipan Dan Perpustakaan Kabupaten Pasaman Barat. Motivasi kerja memediasi pengaruh gaya kepemimpinan transformational dan motivasi kerja terhadap kinerja pegawai dengan organizatioanal citizenship behaviour. Motivasi kerja memediasi pengaruh beban kerja terhadap prestasi kerja. Penulis menyarankan kepada Dinas Kearsipan Dan Perpustakaan Kabupaten Pasaman Barat untuk lebih meningkatkan kinerja pegawai, gaya kepemimpinan transformational dengan organizatioanal citizenship behaviour dan memperhatikan gaya kepemimpinan transformational dan motivasi kerja sehingga diharapkan kinerja pegawai meningkat.
PENGARUH RETURN ON ASSET (ROA) DAN BIAYA OPERASIONAL TERHADAP PENDAPATAN OPERASIONAL (BOPO) TERHADAP PERTUMBUHAN LABA PADA PERBANKAN DI BEI
Authors: Wati Mislina - , Sari Dewi Maya
Published: April 2022

Aspek rentalitas merupakan kemampuan bank dalam meningkatkan labanya, bank yang sehat adalah bank yang diukur secara rentabilitas yang terus meningkat dan penilaiannya juga dapat dilakukan dengan Rasio laba terhadap total asset (ROA) dan perbandingan biaya operasional dengan pendapatan operasional (BOPO), (kasmir, 2005). Return on assets (ROA) adalah rasio profitabilitas yang mengukur kemampuan perusahaan menghasilkan laba dari penggunaan seluruh sumber daya atau aset yang dimilikinya. Sedangkan Biaya operasional pendapatan operasional (BOPO) digunakan untuk mengukur kemampuan manajemen bank dalam mengendalikan biaya operasional terhadap pendapatan operasional. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh Return On Asset (ROA) dan Biaya Operasional Terhadap Pendapatan Operasional (BOPO) terhadap Pertumbuhan laba Pada Perbankan di Bursa Efek Indonesia (BEI) selama tahun 2017-2019. Penelitian ini menggunakan metode penelitian kuantitatif, dan data dianalisis dengan menggunakan analisis regresi linier berganda. Data yang digunakan adalah data sekunder yang merupakan gabungan dari data time series dan cross section. Hasil penelitian menunjukkan bahwa Return On Asset (ROA) berpengaruh terhadap Pertumbuhan Laba, Biaya Operasional Terhadap Pendapatan Operasional (BOPO) berpengaruh terhadap Pertumbuhan Laba.
Kepedulian Dalam Pendidikan Untuk Mencapai Kesetaraan Perempuan
Authors: Damayanti Cicilia
Published: April 2022

Etika kepedulian berhubungan dengan tindakan moral kepada orang lain. Berbicara tentang kesetaraan mempunyai hubungan yang erat dengan para perempuan. Sampai saat ini mereka masih memperjuangkan kesetaraan dalam hidup. Perempuan masih masih sering dianggap sebagai “ahli” dalam ranah domestik. Hal ini menjadikan kepedulian diakui sebagai bagian dalam hidup perempuan. Apakah benar demikian? Melalui pemikiran para tokoh perempuan ditemukan bahwa ternyata pembagian wilayah kepedulian menjadi milik perempuan adalah karena konstruksi budaya semata. Saat ini mulai diperjuangkan suatu perubahan paradigma untuk memberikan kesempatan bagi perempuan dan laki-laki untuk bekerja sama, termasuk dalam wilayah kepedulian. Sarana yang dipakai adalah pendidikan. Pendidikan membuka banyak kesempatan dan kebebasan bagi setiap orang, termasuk perempuan, untuk mengubah hidupnya. Metode dalam artikel ini adalah analisis teks buku-buku tentang etika kepedulian yang ditulis oleh para pemikir perempuan.
Tindak Pidana Apostasia (Murtad) Studi Kanonik
Authors: Galed Daniel Ortega
Published: April 2022

Apostasia, in the penal canon law, is one of the most serious offences. There are at least two fundamental reasons for this; first, apostasia is a direct attack on Christian faith, a fundamental aspect of spiritual life, and secondly, from a juridical perspective, the prescribed canonical sanction is one of the very limited penalties imposed by the codex, namely excommunication latae sententiae (cf. can. 1318). The apostasy is a sensitive and actual topic and therefore needs to be understood properly in order to gain a more comprehensive  understanding of it. The concern about the cases of apostasy within the Catholic Church make us learn more about how and when someone really leaves the Catholic faith totally. At the same time, we are invited to understand the various juridical consequences established by canon law for this offence. The ultimate goal of this study is to make a conceptual contribution to the act of apostasia through canonical analysis and to explain how the punishment of excommunication is abolished. The Church through its juridical system judges and at other times also facilitates how the concrete conversions are realized.

 

Keywords: Apostasia, penal canon law, censura, excommunication, the remission of canonical penalties
Epistemologi Dalam Pemikiran Alfred North Whitehead
Authors: Putrawan Bobby Kurnia
Published: April 2022

Alfred North Whitehead adalah pemikir besar Inggris yang telah membidani dan mengembangkan filsafat proses yang disebut filsafat organisme. Dengan komitmen dan ketekunan yang penuh ketelitian, Whitehead menempuh proses demi proses ke arah satu kesatuan konjungtif, menyangkutkan ilmu pada pengetahuan (episteme to logos). Artikel ini meneliti bagaimana gagasan epistemologi Alfred North Whitehead dengan menggunakan penelitian literatur. Hasil penelitian ini menunjukkan bahwa tidak dapat dipungkiri bahwa pemikirannya menjadi gagasan-gagasan dalam mengintegrasikan dan mengembangkan perkembangan keilmuan di bidang yang lain termasuk teologi.
FABC (Federation of Asian Bishops’ Conferences):
Authors: Tinambunan Edison R.L. , Budiono Ignasius
Published: April 2022

One of the central themes discussed both internationally and nationally is about humanity which is identified with human rights. Religiosity is no less talked about it, including the Church of Asia through the Asian Bishops' Conference which in 2020 celebrated its presence for fifty years. Two declarations from the United Nations and the ASEAN declaration provide directions for upholding humanity and the Asian Bishops Conference document provides the basis for humanity to be more honored and respected. To arrive at the aim of discussing the contribution of the Asian Bishops' Conference to respect and honor humanity, the discussion will begin with an overview of humanity from religious and philosophical dimensions. The two United Nations declarations and the ASEAN declaration provide directions for humanity that serve as guidelines for respecting it. The document of the Asian Bishops' Conference, while respecting the declarations issued by various agencies, illuminates the implications for respecting and respecting humanity. This study uses many sources of documents and humanitarian movements in Asia and Indonesia as well and this paper concludes with a conclusion that gives the reason for Asia being the highest violator of humanity in the world.
Maqāṣid and the Renewal of Islamic Legal Theory in ʿAbdullah Bin Bayyah’s Discourse
Authors: Beka Rezart
Published: April 2022

This article investigates the central role assigned to maqāṣid by ‘Abdullah Bin Bayyah (b. 1935) in his project of renewal of uṣūl al-fiqh. He presents maqāṣid as crucial for the functioning and widening of the system of ratiocination (manẓūmat al-taʿlīl) and inference (istidlāl). In his theory of renewal, Bin Bayyah expands the role of maqāṣid in uṣūl al-fiqh beyond the system of ratiocination to all the chapters of uṣūl al-fiqh. In this context, he provides more than thirty ways in which maqāṣid are blended into the texture of Islamic legal theory and are necessary for its sound functioning. In this way, he tries to demonstrate that maqāṣid are uṣūl al-fiqh itself and its heart. This article explores the discursive strategies adopted by Bin Bayyah to establish the relevance of maqāṣid for the renewal of uṣūl al-fiqh and offers a succinct critical appraisal of Bin Bayyah’s reasoning on the topic. It argues that Bin Bayyah is successful in demonstrating the indispensability of maqāṣid for any project of renewal of uṣūl al-fiqh, but falls short in proving that maqāṣid are uṣūl al-fiqh itself and its heart.
Sufism in Ottoman Egypt Circulation Renewal and Authority in the Seventeenth and Eighteenth Centuries (by Rachida Chih)
Authors: Murat Talha
Published: April 2022

This book examines Sufism in Ottoman Egypt in the seventeenth and eighteenth centuries. Contrary to the traditional historiography that interpreted these two centuries as a period of stagnation and/or decline for Sufism and Sufi scholars, Rachida Chih argues that these centuries were fruitful, productive, and dynamic for Sufism in Ottoman Egypt. Chih builds her narrative around the mobilization and interaction of ideas, people, and institutions, focusing her thesis on the Khalwatiyya Sufi order.
Forging Ideal Muslim Subjects: Discursive Practices, Subject Formation, & Muslim Ethics (by Faraz Masood Sheikh)
Authors: Houston Sam
Published: April 2022

In the fields of Muslim ethics and comparative religious ethics over the past two decades, embodiment and embodied practices have reigned as rich methodological loci yielding numerous illuminating studies on the nature and process of ethical formation, in large part because of the pioneering work of anthropologist of Islam, Talal Asad. But as is often the case with scholarly methodologies, the pendulum has begun to swing back, in this case towards an interest in theological and philosophical reasoning as crucial to understanding how religious and moral selves are formed—for example, in Thomas A. Lewis’s 2016 Why Philosophy Matters for the Study of Religion & Vice Versa. Presenting himself as standing firmly in the camp of this nascent trend, Faraz Masood Sheikh offers his Forging Ideal Muslim Subjects: Discursive Practices, Subject Formation, and Muslim Ethics as a study of both Muslim and comparative religious ethics that takes the power of ideas and reasoned reflection seriously in ethical formation. Sheikh seeks to demonstrate this primarily through an analysis of the thought of two important and understudied Muslim thinkers, the ninth-century moral pedagogue, al-Ḥārith ibn Asad al-Muḥāsibī (d. 243/857) and the twentieth-century Kurdish Qur’an scholar, Bediüzzaman Said Nursi (d. 1960).
AbdulHamid Ahmad AbuSulayman’s Legacy of Intellectual Reform
Authors: Ahmad Imad-ad-Dean
Published: April 2022

The death of the 84-year-old scholar and activist AbdulHamid Ahmad AbuSulayman on August 18, 2021, marked the return to Allah of an influential thinker who, well-grounded in Islamic traditional thought, strove to address modern problems by historically- and contextually-aware applications of well-grounded Islamic principles. This essay seeks to present an intellectual overview of some of his most important work in a manner that honors the impact he has had on Islamic thought and on Muslim thinkers.
Ekologia integralna jako przestrzeń uczenia się szacunku przez dziecko w wieku przedszkolnym
Authors: Samborska Iwona
Published: April 2022

Artykuł zawiera propozycję usytuowania procesu uczenia się wartości przez dziecko w wieku przedszkolnym w kontekście ekologii integralnej. Problematyka tekstu koncentruje się na wartości, jaką jest szacunek. Pierwsza część skupia się na ukazaniu perspektywy integralnej w edukacji, obecnej w tym obszarze za sprawą tzw. zwrotu integralnego (Marzec 2019: 215–216). W dalszej części opracowania zwrócono uwagę na wyłanianie się w przestrzeni edukacji wizji ekologii integralnej (Wysocki 2016; Sędek 2019). Wskazano na integralny wymiar edukacji dziecka, odnosząc go do perspektywy ekologicznej. W końcowej części dokonano identyfikacji najważniejszych wyznaczników konstruowania szacunku jako kategorii edukacyjnej. Ukazano możliwości edukacyjnego działania w perspektywie ekologii integralnej, przywołując w tym zakresie sferę poszanowania żywności. Celem artykułu jest zaprezentowanie specyfiki ekologii integralnej i ukazanie podejścia integralnego jako płaszczyzny, na której tle rozpatrywany jest problem uczenia się wartości przez dziecko w wieku przedszkolnym.
Dziecięca Meteorologia. Rozumienie przez dzieci zjawisk pogody w różnych częściach świata
Authors: Jelinek Jan Amos
Published: April 2022

W artykule scharakteryzowano dziecięcą ocenę stanu pogody w różnych częściach kraju i świata. Celem przeprowadzonych badań było ustalenie dziecięcych kompetencji w zakresie oceny stanu pogody oraz umiejętność przewidywania pogody w innych częściach świata, w odniesieniu do aktualnie panującej pogody w miejscu zamieszkania. Badania przeprowadzono wśród 42 dzieci (21 dzieci w wieku 6/7 lat oraz 21 uczniów 9/10 lat). Badania miały charakter jakościowy, zastosowano metodę wywiadu, podczas którego dzieci kodowały pogodę (za pomocą serii obrazków) obserwowaną na ekranie komputera (w miejscu zamieszkania) i na tej podstawie wnioskowały o pogodzie w miejscach pokazywanych na mapie kraju i globusie. W prezentacji wyników scharakteryzowano pogodę w Szczecinie, Warszawie i Rzeszowie oraz Azji, Afryce, Australii, na biegunach i wyspach Tahiti. Porównano dziecięce prognozy pogody osobno dla pory zimowej i letniej. Zwrócono uwagę na różnice we wskazaniach stanów pogody względem wieku (dzieci 6- i 9-letnich). Okazało się, że 30% badanych (częściej dzieci w wieku przedszkolnym) postrzega pory roku jako zjawisko, którego różnice w pogodzie widać już w skali kraju. Biegun południowy jest oceniany przez dzieci jako rekordowo zimne miejsce na Ziemi. Przeanalizowano źródła dziecięcej wiedzy i wskazano możliwe przyczyny błędnych przekonań.