bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimization of preemptive therapy for cytomegalovirus with valganciclovir based on therapeutic drug monitoring: Protocol for a phase II, single-center, single-arm trial (Preprint)
Authors: Tamura Naoki , Itohara Kotaro , Ueda Yo , Kitahiro Yumi , Yamamoto Kazuhiro , Omura Tomohiro , Sakane Toshiyasu , Saegusa Jun , Yano Ikuko
Published: February 2025

BACKGROUND

Valganciclovir (VGCV) is the first-line drug for preemptive therapy of cytomegalovirus (CMV). However, even when administered at the dose specified in the package insert, there is significant inter-individual variability in the plasma concentrations of ganciclovir. In addition, correlations between the area under the concentration–time curve (AUC) and therapeutic efficacy or adverse events have been reported. Therefore, therapeutic drug monitoring (TDM) can be used to improve the efficacy and safety of preemptive VGCV therapy.

OBJECTIVE

This study aims to evaluate whether the dosage adjustment of VGCV based on TDM in patients undergoing preemptive therapy for CMV is associated with a successful completion rate of treatment without severe hematological adverse effects.

METHODS

This ongoing phase II, single-center, single-arm trial aims to enroll 40 patients admitted at the Department of Rheumatology and Clinical Immunology, Kobe University Hospital who will receive oral VGCV as preemptive therapy for CMV. Participants will begin treatment with VGCV at the dose recommended in the package insert, with subsequent dose adjustments based on weekly TDM results. The primary endpoint will be the proportion of patients who achieve CMV antigenemia negativity within 3 weeks without serious adverse events. The secondary endpoints will include weekly changes in CMV antigen levels, total VGCV dose, and duration of preemptive therapy. For safety evaluation, the occurrence, type, and severity of VGCV-related adverse events will be analyzed. Additionally, the study will explore the correlations between the efficacy and safety of preemptive therapy and the pharmacokinetic parameters of GCV, CMV-polymerase chain reaction values, and NUDT15 genetic polymorphisms. The correlation between GCV plasma concentrations and blood concentrations using dried blood spots will be examined.

RESULTS

This study began with patient recruitment in September 2024, with two participants enrolled as of February 1, 2025. The target enrollment is 40 participants, and the anticipated study completion is set for July 2027.

CONCLUSIONS

This is the first study to investigate the impact of TDM intervention in patients receiving VGCV as preemptive therapy. The findings are postulated to provide valuable evidence regarding the utility of TDM in patients receiving VGCV as preemptive therapy.

CLINICALTRIAL

Japan Registry of Clinical Trials jRCTs051240080; https://jrct.niph.go.jp/latest-detail/jRCTs051240080
Zones Localization of Hazardous Geological Processes Habit of the Coastal Cliff According to 3D Seismotomography Sounding Data
Authors: Glazunov Vladimir , Efimova Natal’ia , Zelikman Danil , Bukatov Andrei
Published: February 2025

The article presents a methodology for conducting 3D seismic tomography of rock massifs. This technique has been developed for the identification and localisation of zones of development of dangerous geological processes formed within the rock massif of a coastal cliff. An example of the application of the technique is provided by the results of seismic tomography, which were used to study the state of a coastal cliff in Crimea that is subject to abrasion. The seismic tomographic inversion process has been utilised to generate maps depicting the distribution of and velocity values of seismic waves within the rock massif at varying depths. Furthermore, the dynamic moduli of elasticity, which are indicative of the physical and mechanical properties of the rocks constituting the cliff, have been calculated. The maps that have been generated by the seismic tomographic inversion process reflect the spatial distribution of these parameters, and the maps also localise the zones that have been weakened, presumably as a consequence of the formation and development of negative geological processes that are dangerous for the cliff's stability.
On Social Media Translation and Localization: Strategies and Challenges in Cross-Cultural Communication
Authors: Zhu Liqin
Published: February 2025

Social media plays an important role in today’s society, and its internationalization and localization are key to facilitating cross-cultural communication. This paper aims to explore translation and localization strategies on social media platforms, as well as challenges and solutions to successfully disseminate information in different cultural environments. Through literature review and case analysis, this paper analyzes the importance of social media translation and localization, and discusses the current challenges and coping strategies with a view to providing reference and inspiration for research and practice in related fields.
Artificial Intelligence in Agricultural Water Management Research: Literature Review and Research Agenda
Authors: Farig Mohamed , Shimizu Katsuyuki , Hassan Waleed H. Abou El
Published: February 2025

Artificial intelligence (AI) enhances agricultural water management by enabling precise, efficient, and sustainable irrigation practices. With rising water scarcity and the demand for increased productivity in agriculture, AI-powered applications provide innovative approaches for irrigation scheduling, water use efficiency, and decision support. This study investigates the use of AI in agricultural water management, concentrating on methodology, applications, and advantages. Different case studies and developing algorithms are also discussed to provide a detailed understanding of AI- AI-transformative methods. The case studies show that incorporating AI into agricultural water management promotes sustainable practices by reducing water use and environmental effects. This proactive approach saves water, increases water use efficiency, and provides real-time monitoring of the main components of agricultural water management, contributing to sustainable irrigation and farming developments. Eventually, developing an AI-ANN model to assess the complex nonlinear relationships in water balance is essential for the large-scale assessment.
Ecclesiastical deviation in the early 19th century and its traces in scott’s st. ronan’s well
Authors: Chauhan Vivek
Published: February 2025

The present study focuses on the general neglect of church and the unwanted practices that crept into the ecclesiastical system during the early 19th century and the traces that are researched from Sir Walter Scott’s novel St.Ronan’s Well . The study compasses a general look into the various deviations related to churches and the poor choice of the authorities in appointing Josiah Cargill as the minister of the Parish of St.Ronan’s Well.The study aims to bring to light the various ills that creep into a system, underlining the reasons that lead to such deviations and the need to appoint only such individuals who are totally aware of their responsibility towards society.
Cómo los topónimos en la lengua seri nos informan sobre el paisaje
Authors: Castillo Tapia Oscar , O'Meara Carolyn
Published: February 2025

Este trabajo se centra en el estudio de algunos topónimos en la lengua seri —o cmiique iitom—, una lengua aislada hablada en el estado de Sonora, México, por los comcaac (seris). El objetivo de este trabajo es explorar la manera en que tanto los aspectos del territorio como de la vida cotidiana de los comcaac se expresan a través de dichos términos, la mayoría de los cuales son expresiones complejas (multimorfémicas), con algunos pocos siendo formas simples (monomorfémicos). La mayoría, si no todos, de los topónimos complejos son analizables morfológica y semánticamente por los hablantes de la lengua seri, lo cual quiere decir que podrían codificar información útil sobre sus referentes, en particular información sobre el ambiente, prácticas culturales, entre otras cosas. Conformamos una base de datos de topónimos en seri que están georeferenciados en un sistema de información geográfica (SIG), y a través de ella examinamos un conjunto de sustantivos simples que son recurrentes en los topónimos para ver si éstos nos dan pistas sobre sus propiedades referenciales, en particular sobre los tipos de accidentes geográficos que los nombran. Encontramos que algunos de los sustantivos corresponden al tipo de accidente geográfico que nombra el topónimo, pero en algunos casos no coinciden.
Enhancing Secrecy Capacity Using Reconfigurable Intelligent Surfaces in Line-of-Sight (LOS) Scenarios for Beyond 5G Networks
Authors: Shahzad Taha
Published: February 2025

Physical Layer Security (PLS) is a promising approach for securing the Beyond 5G (B5G) wireless networks by
exploiting the physical properties of communication channels.
Reconfigurable Intelligent Surfaces (RIS) are used to enhance PLS by dynamically controlling signal reflections to favor the
legitimate users while degrading eavesdropper channels. This paper focuses on using RIS to improve the secrecy capacity in
Line-of-Sight (LOS) scenarios.
Consenso colombiano sobre la poliquistosis renal autosómica dominante
Authors: Roncallo Angelica , Aguirre Marcelo , Conde Manotas Juan Carlos , Gallón Blandón Paula Andrea , Lopera Mauricio , López José Gabriel , Mantilla Andrea , Martínez Theo , Olivares Orlando , Restrepo-Valencia Cesar Augusto , Wassermann Alfredo Osvaldo , Bermon Anderson , Barros Luis
Published: February 2025

Contexto: la poliquistosis renal autosómica dominante (PQRAD) es la causa más frecuente de nefropatía hereditaria en el adulto y de enfermedad renal crónica estadio 5 de origen genético, además, es una enfermedad heterogénea con una variabilidad fenotípica con relación a la progresión, por lo que es necesario establecer todas las medidas encaminadas a enlentecer la progresión de la enfermedad renal.
Objetivo: generar recomendaciones basadas en la evidencia para el diagnóstico, seguimiento y tratamiento del paciente con PQRAD, definiendo los pacientes con rápida progresión de la enfermedad, guiar el tratamiento general y específico con el agente tolvaptán, y establecer recomendaciones para el acceso a terapias de reemplazo renal, incluido el trasplante, mediante un consenso de expertos.
Metodología: a partir de la formulación de preguntas de investigación pragmáticas relacionadas con la PQRAD, se realiza la búsqueda de evidencia en las bases de datos Pubmed, Scopus y Ovid en el periodo de enero del 2012 a julio del 2023. Los artículos se seleccionaron por medio de una revisión sistemática y a través de la metodología de consenso Delphi modificado. Luego, se aplicó la escala Oxford para cuantificar el nivel de evidencia del total de artículos científicos seleccionados. Todas las recomendaciones finales fueron categorizadas por grado según la clasificación de las guías NHS.
Resultados: se formularon en total 18 recomendaciones para el diagnóstico, tratamiento y seguimiento de la PQRAD, participaron un panel de 10 expertos temáticos, 1 experto metodológico y 2 revisores externos de forma activa para la elaboración del consenso.
Conclusiones: las recomendaciones basadas en evidencia y experticia clínica adaptadas al contexto colombiano permitirán orientar de manera estandarizada, a nivel nacional y regional, el diagnóstico y el tratamiento de pacientes con PQRAD y orientar sobre el uso y aplicación de tolvaptán.
Brechas metodológicas en la determinación de hemoglobina y albúmina glicosilada en el diagnóstico y seguimiento de la nefropatía diabética
Authors: Rivadeneira Arévalo María , Ponce Roberto , Robles Urgilez María , Bracho Mora Angela
Published: February 2025

Contexto: los biomarcadores son ampliamente empleados para monitorear complicaciones de diversas enfermedades crónico-degenerativas como la diabetes mellitus (DM) y también son parte de un campo de profundo dinamismo, en el cual ha habido importantes avances metodológicos y se han empleado nuevas técnicas analíticas para su determinación e interpretación. Las complicaciones renales relacionadas con DM representan un desafío en la práctica médica, debido a la elevada tasa de mortalidad que generan. Por su parte, la hemoglobina glicosilada (HbA1c) ha sido, por larga data, un biomarcador de gran importancia. En la actualidad, también se emplea la albúmina glicosilada (AG), sin embargo, existe divergencia en su uso.
Objetivo: se realizó una revisión sistemática, con el objetivo de evaluar los beneficios de ambos biomarcadores paraclínicos, instaurando criterios de inclusión para tal fin.
Metodología: se establecieron los descriptores MeSH y, una vez realizada la búsqueda bibliográfica, se procedió a realizar el flujograma propuesto por la declaración Prisma y a sintetizar los principales hallazgos.
Resultados: se seleccionaron 15 manuscritos que mostraron que la AG es un parámetro emergente que puede determinar, con una mayor sensibilidad y especificidad, la progresión hacia los estadios más avanzados de la enfermedad renal y la mortalidad en pacientes diabéticos, aunque posee desventajas con respecto a la HbA1c, como la ausencia de un rango de referencia y la falta de su uso continuo en los laboratorios de rutina, debido a la metodología inherente.
Conclusiones: la HbA1c continúa siendo el biomarcador de mayor uso, sin embargo, debe promoverse el uso de la AG como una nueva herramienta de utilidad en el manejo de los pacientes diabéticos nefrópatas.
MORPHOSTRUCTURAL COMPONENTS OF THE BUSH AND THEIR RELATIONSHIP WITH THE PRODUCTIVITY OF THE VARIETY SAMPLES OF THE LARGE-FRUITED STRAWBERRY IN THE CLIMATE OF THE KAMCHATSKY TERRITORY
Authors:   Kamchatsky Research Institute of Agriculture, Dakhno T.G. , Dakhno O.A. ,   Kamchatsky Research Institute of Agriculture
Published: February 2025

The article presents the findings of investigations on the morphostructural components of the
bush and productivity in 24 variety samples of large-fruited strawberry of various ecological and
geographical origin under the conditions of the Kamchatka Region and determining the degree of
dependence between them based on correlation analysis. The studies were carried out on the experimental plot of the Kamchatsky Research Institute of Agriculture (Kamchatsky RIA) in years 2012-
2016. As the result of the research, varieties with the maximum intensity of individual productivity
components as well as their complex combination were revealed. Selection criterion - number of
flower stalks per bush, varieties selected: Feya, Feyyerverk, Solnechnaya Polyanka, Yaponka, Grenada, Fruktovaya, Pervoklassnitza; number of flowers per flower stalk – varieties: Maryshka, Korrado, Lidiya Norvezhskaya, Anastasiya, Galina, Solnechnaya polyanka, Pervoklassnitsa, Yaponka,
Feya, Atlas; average weight of the berries – varieties: Vengerka and Yaponka. Yaponka variety was
selected in accordance with the above-said criterions: number of flower stalks per bush, number of
flowers per flower stalk and the average weight of berries. The following varieties with high productivity potential were identified: Yaponka, Pervoklassnitsa, Atlas, Fruktovaya, Grenada (308,0-869,4
g a bush). Realization of the potential productivity of strawberry varieties was recorded within 25,0%
to 56,0%. We found a high degree of influence on the potential productivity of the average weight of
the berries (r = 0,73) and the number of flower stalks per bush (r = 0,71). The dependence of the
average strength is revealed between the potential productivity and the number of flowers per flower
stalk (r = 0,60). A high degree of relationship between the actual productivity and the average weight
of the berries (r = 0,71) was confirmed. Positive relationships of average strength were found between the actual productivity and such components of the morphological structure of the bush as the
number of flower stalks per bush (r = 0,68), the leaf area per bush (r = 0,67), the number of leaves
per bush (r = 0,53), the number of flowers per flower stalk (r = 0,52). We also noticed strong association of the level of actual productivity of varieties with the calculated value of potential productivity (r = 0,89).
USE OF WINTER FORMS IN BREEDING OF SOFT SPRING WHEAT (ТRITICUM AESTIVUM L.) IN PRIMORSKY KRAI
Authors:   Federal Scientific Center of Agrobiotechnology in the Far East named after A. K. Chaika, Klykov A.G. , Timoshinova O.A. ,   Federal Scientific Center of Agrobiotechnology in the Far East named after A. K. Chaika, Bogdan P.M. ,   Federal Scientific Center of Agrobiotechnology in the Far East named after A. K. Chaika, Konovalova I.V. ,   Federal Scientific Center of Agrobiotechnology in the Far East named after A. K. Chaika, Timoshinov R.V. ,   Federal Scientific Center of Agrobiotechnology in the Far East named after A. K. Chaika
Published: February 2025

The article presents the findings of investigations on varieties of soft spring wheat carried out in
the course of competitive tests on economically valuable characteristics (yield, resistance to lodging,
diseases, technological, and biochemical qualities of grain). The studies were conducted at the Federal Scientific Center of Agrobiotechnology in the Far East Named after A. K. Chaika in 2016-2018.
The following varieties were taken as the objects of the research: Primorskaya 209 (Primorskaya 40
x Don 95), Primorskaya 222 (Primorskaya 39 x Spartanka), Primorskaya 225 (Primorskaya 39 x
Bezostaya 1), Primorskaya 235 (Primorskaya 50 x Kuma) and Primorskaya 242 (Primorskaya 40 x
Kuma), obtained by crossing spring varieties with winter varieties. The research showed that in comparison with the maternal forms and standard Primorskaya 39, taking into account the elements of
productivity, there were distinguished varieties Primorskaya 235 – 3,3 t/ha and Primorskaya 222 –
3,1 t/ha. High technological and biochemical qualities of grain (weight of 1000 seeds, vitreousness,
grain-unit, protein and gluten) were detected in the following varieties: Primorskaya 209 and Primorskaya 222. Against the natural infectious background, the following varieties were relatively low
damaged by seedling blight (about 7,5%): Primorskaya 235, Primorskaya 222, Primorskaya 242,
Primorskaya 209 and Primorskaya 50. The correlation analysis revealed a significant average positive relationship between the yield and the grain-unit (r = 0,52). Winter varieties Spartanka, Kuma,
Don95 are recommended to use in breeding of soft spring wheat to increase the potential productivity
and improve the grain quality in the climate of the Primorsky Krai.
USING ICE WATER GENERATOR FOR INSTANT COOLING OF MILK
Authors:   Primorskaya State Academy of Agriculture, Shishlov Sergey A. , Demeshko Andrey A. ,   Primorskaya State Academy of Agriculture, Shishlov Aleksandr N. ,   Primorskaya State Academy of Agriculture, Chugaeva Natalya A. ,   Primorskaya State Academy of Agriculture
Published: February 2025

In the technology of primary processing of milk, the process of cooling it takes an important place,
which can be performed using various technical means. The article discusses the device, operating principle
and technological process of the ice water generator of the original design used for instant cooling of milk.
The article presents some results of the research carried out into the design parameters of panel-type evaporators used in an ice water generator with a pulse mode.
OPTIMIZATION OF ENERGY COST OF TRANSPORTATION AND PRODUCTION PROCESS
Authors:   Far Eastern State Agrarian University, Shchitov Sergey V. , Krivutsa Zoya F. ,   Far Eastern State Agrarian University, Kuznetsov Evgeny E. ,   Far Eastern State Agrarian University, Evdokimov Vacheslav E. ,   The Marshal of the Soviet Union K. K. Rokossovsky Far Eastern Higher Combined Arms Command School of the Russian Armed Forces, Shchegorets Olga V. ,   Far Eastern State Agrarian University, Kurkov Yurii B. ,   Far Eastern State Agrarian University, Dvoinova Natalya F. ,   Sakhalin State University
Published: February 2025

The efficiency of transport and production operations depends on the mutually agreed work of road
transport, harvesting machines and functioning of reception points. The degree of adaptability to perform the
functions assigned to them allows you to assess the efficiency of using road transport in transporting goods
according to the “field-elevator” scheme. One of the criteria for assessing the efficiency of road transport is
full energy cost per unit. The introduction of this research recommendations, taking into account the modeling
of cargo flows, makes it possible to reduce energy cost during the transportation of agricultural goods, taking
into account the location of production facilities with which these cargo flows are associated.
Assessment of the collection of the moustached varieties of pea to create lodging resistant variety in Yakutia
Authors:   Yakut scientific center Siberian Branch of the Russian Academy of Sciences, Yakut research Institute of agriculture named after M.G. Safronov, Neustroev Aleksey N. , Bardeev Ivan F. ,   Yakut scientific center Siberian Branch of the Russian Academy of Sciences, Yakut research Institute of agriculture named after M.G. Safronov
Published: February 2025

The article presents the findings of testing moustached varieties of seedling (sown) pea from the
world collection of the All-Russian Research Institute of Plant Genetics Named after N. I. Vavilov (Vavilov
Institute of Plant Industry (VIPI)) in order to select the source material for breeding a variety resistant to lodging, suitable for single-phase harvesting and adapted to the conditions of Yakutia. The work was carried out
according to the generally accepted methods of VIPI. Field work was carried out during years 2011-2015 at
the experimental farm of the Yakut Research Institute named after M. G. Safronov located on the second
terrace above the floodplain of the Lena River, Khangalassky Ulus, the Republic of Sakha (Yakutia). According to the morphological description, the soil of the experimental plot is of taiga-frost type, pale-yellow, granulometric composition: medium-loamy, cultivated. The main assessment criteria: resistance to lodging-4 varieties were selected here (Batrak, Yamalsky, Madonna, K-1 «Saryal»); multiplicity of fruits on the flower stalk
– 2 varieties (Demos and Batrak); number of seeds in a bean-2 varieties (Multik and Demos).
Pathogen resistance of cultivated and wild soybean under artificial infection with the pathogen Septoria glycines Hemmi
Authors:   FSC for Biodiversity FEB RAS, Veremeichick Galina N. , Brodovskaya Evgeniya V. ,   FSC for Biodiversity FEB RAS, Butovets Ekaterina S. ,   Federal Scientific Center for Agrobiotechnology in the Far East named after A.K. Chaika, Lukyanchuk Lyudmila M. ,   Federal Scientific Center for Agrobiotechnology in the Far East named after A.K. Chaika
Published: February 2025

Soybean is one of the most important agricultural crops in the world, for it is a source of vegetable
protein, oil and other by-products. Cost-effective soybean cultivation in the unfavorable climate of the Russian
Far East is complicated by a variety of fungal infections, one of the most common of which is leaf spot of
soybean (Septoria glycines Hemmi). The aim of the presented work was to conduct in vitro analysis of the
growth parameters of the varieties Sphere, Hefeng 25, Hodson and wild Ussuriysk soybean, that were infected
with leaf spot of soybean (Septoria), and to assess the susceptibility of soybean samples to the pathogen against
the provocative background. It was proved that the leaf spot (Septoria) actually inhibits the growth of wild
soybean and the Hodson variety, and does not have an inhibitory effect on the development of the Sphere and
Hefeng 25 varieties. When the soybean samples were tested in the field, it was found that, against an artificial
infectious background of the disease, variety Sphere of Primorsky selection and Chinese variety Hefeng 25 had lower percentage of infection with leaf spot (Septoria) – 67 and 65%, respectively. Wild Ussuriysk soybean
proved to be more susceptible to the pathogen Septoria glycines Hemmi. The results of the work showed the
possibility of using in vitro experiments involving leaf spot (agent-Septoria) infection in the selection process
for breeding soybean varieties resistant to fungal infections.
Superstitious Beliefs and Practices among The Fulbe in Nigeria: Causes, Types, Effects and Solutions from The Islamic Perspectives
Authors: Abubakar Ahmad Yahaya , Gokaru Shuaibu Umar
Published: February 2025

Superstitious beliefs are cultural practices, which have been found in many cultures, ethnic groups and religions around the globe. The research aims at investigating the superstitious practices among Fulbe in Nigeria. It also looks into the causes, types and effects of superstitious beliefs and practices. The study area and as well provides some solutions from the Islamic perspective. The research adopts fieldwork and conventional research methods to gather the necessary research information. This is done by consulting previous research works done on the subject like journals, articles, textbooks and interviews conducted. The research discovers that ignorance made the Fulbe adopt these cultural practices. It also finds that some of these beliefs were generated based on false hope or fear of unknown circumstances. Islam attacks superstitious beliefs, thus it is revealed that it leads Muslim believers to go astray. The research concludes that piety will be achieved if Muslim should embark on seeking Islamic knowledge. And in this regard, Modibbe (scholars), Government and Islamic organization have important roles to play in Fulbe communities in Nigeria.
أثر سياسة الدولة الإسلامي على توازن سوق السلع والخدمات The Impact of The Islamic State's Policy on The Balance of The Goods and Services Market
Authors: Al-Araimi Khaloud Hamood Hamed , Murshed Amer Abdulwahab Mahyoub , Rasip Osman Md
Published: February 2025

This article seeks to elucidate the impact of the Islamic state's intervention policy on achieving national economic equilibrium. The study aims to explore the overall legal policies of Islamic state intervention throughout its history, their effect on the balance of goods and services markets. The study addresses the complexity of current economic reform policies, emphasizing the significance of shedding light on the Islamic system and its legitimate paths in providing solutions for stabilizing national economic markets, particularly the goods and services market. Employing a descriptive-analytical approach, the study reveals several conclusions, including the Islamic state's duty to protect its communities, encompassing not only matters of faith and worship but also safeguarding the wealth and natural resources of Muslims. The study underscores the necessity of implementing structural reforms in the goods and services market, emphasizing their positive impact on economic activity and growth. It highlights the greatness of the Islamic economic system, distinguishing it from contemporary economic systems, emphasizing Islam's comprehensive nature, covering all aspects of life, including economics, administration, governance, and politics.
Pengaruh Kerajaan Hafsid, Ilkhanid dan Rasuliyyah di Mekah dan Implikasi Terhadap Pemerintahan Sharif Mekah Pada Era Mamluk The Influnce of Hafsid, Ilkhanid and Rasulid in Mecca and Its Implication Towards the Sharifate of Mecca During the Mamluk Era
Authors: Mahmood Mohamad Yusof Shah , Mohd Nor Mohd Roslan
Published: February 2025

Mecca is the Muslim’s holiest land in the world and Ka’abah as a symbol of unity in Islam. During Mamluk’s rule, before and after them Mecca is administerd by the Sharif of Mecca among Bani Qutadah whom are legitimate descendants of Prophet Muhammad PBUH. More over beside Mamluk Mecca has become a place where some of Muslim rulling dynasties like Hafsid, Ilkhanid and Rasulid are compeating towards spreading their influences in order to gain legitimacy for their government. This research is done to find out what kind of implication from spreding their influences in Mecca towards the Sharifate government and therefore qualitative method is applied to collect historical data and analysis by descriptive. The outcome of this research found that there is an inconsistency impact of implication towards Sharifate administration based on condition dan situation which found to be positive and negative as well.
Sejarah Pemerintahan Sultan Mahmud II dalam Kerajaan Uthmaniyyah (1808-1830 M) History of The Reign of Sultan Mahmud II in The Uthmaniyyah Kingdom (1808-1830 AD)
Authors: Bakri Mohamad Fikri Mohd , Ishak Muhammad Farhan
Published: February 2025

Sultan Mahmud II was one of the most significant figures in the history of the Ottoman Empire. He ruled in the 19th century and faced various challenges in his efforts to restore and strengthen the empire, which was in a state of decline. This journal article discusses Sultan Mahmud II's contributions to the development of Islam, particularly in the context of the political, social, and economic changes that shaped Ottoman history. The main objective of this study is to examine Sultan Mahmud II's contributions to preserving and modernizing the Ottoman Empire and to understand their impact on the development of Islam. The study also aims to explore the steps and policies taken by Sultan Mahmud II in his efforts to address the challenges faced by the empire during his reign. This study employs a historical approach by analyzing historical sources, including relevant documents and historical writings. The analysis is conducted through a qualitative approach to understand Sultan Mahmud II's influence and contributions in the context of Islamic and Ottoman history. The study's findings indicate that Sultan Mahmud II played a significant role in modernizing the Ottoman Empire. He implemented crucial reforms in administration, the military, and the economy of the empire. These reforms had a positive impact on the development and stability of the Ottoman Empire and helped maintain Islam's position as the primary religion within the empire.
Zionisme dan Peranannya Dalam Kejatuhan Turki Uthmaniyah Zionism and Its Role In the Fall of the Ottoman Empire
Authors: Zaki Husna Khaleedah , Azman Iffah Syadiyah , Yusnan Muhammad Ridhuan , Mohd Nor Mohd Roslan
Published: February 2025

This article explores the complex role of Zionism in the political and territorial decline of the Ottoman Empire. Drawing on historical accounts, archival documents, and scholarly analyses, the study examines the emergence of the Zionist movement in the late 19th century and its interplay with the geopolitical dynamics of the Ottoman era. It investigates the socio-political aspirations of Zionist leaders, the impact of European colonial interests, and the response of Ottoman authorities to the increasing migration and settlement of Jewish communities in Palestine. The analysis highlights how Zionist ambitions aligned with external pressures, including European powers' strategic exploitation of Ottoman weaknesses, contributing to internal destabilization and territorial fragmentation. By contextualizing Zionism within the broader spectrum of imperial decline, the article provides a nuanced understanding of the interplay between ideological movements, foreign intervention, and domestic challenges in the disintegration of one of history's most enduring empires. This study offers valuable insights into the historical foundations of contemporary Middle Eastern conflicts and their roots in the late Ottoman period.
MUHAMMAD ABDUH’S INFLUENCE ON AL-WAQĀI’ AL-MIṢRIYYAH: SHAPING EGYPT’S OFFICIAL GAZETTE
Authors: Ahmad Nabil Amir  , Tasnim Abdul Rahman
Published: February 2025

This research aims to discuss the role of Muhammad Abduh (1849-1905) as the leading editor of al-Waqāi‘ al-Miṣrīyyah (Egyptian Events), an official Egyptian gazette. His editorial work has had a profound impact on its progress in the context of the rising popularity of al-Waqāi‘ al-Miṣrīyyah during his editorship (1880-1882), establishing its reputation as a leading Egyptian newspapers. This study contributes to illuminating Abduh’s column and writing that was instrumental in highlighting unprecedented socio-cultural and religious reform undertaken by the government, amid phenomenal and competitive growth of independent press and helped to develop a national consciousness of modernizing programs and influencing public opinion in Egypt. It allowed for better development of formidable national spirit and mainstreaming of their common ideal and convention in language, literature and culture as well as mobilizing social awareness of intense political and cultural dynamics in the Egyptian heartland. His career spanned the period of Riyad Pasha and Sharif’s administration and subsequent political unrest. The research is based on qualitative and documentation techniques. It reviewed accumulated data by way of descriptive, analytical, historical and comparative methods. The main finding delineates that al-Waqāi‘ has assumed unprecedented influence and success during his editorship through his dynamic and productive articles and rigorous daily basis of production of the newspaper that helps to raise public issues and concern and attract awareness of global political current as well as defending the significance value, norms and ethics of journalism.
Introducción a los procesos de manufactura
Authors: Ortiz Sánchez Yesid , Cañas Mendoza Luz Adriana , Marulanda Arevalo Jose Luddey
Published: February 2025

El presente texto es el resultado de la experiencia como docentes universitarios de sus autores, quienes han impartido en sus universidades diferentes cátedras que involucran los procesos de manufactura. Es por ello que en el texto se plasma de forma clara y práctica conceptos generales de cada uno de los procesos de manufactura con los que estará involucrado el estudiante de ingeniería de manufactura y de ingeniería mecánica, al inicio de su carrera, principalmente el texto está dirigido a cubrir contenido programático de la asignatura introducción a la ingeniería de manufactura, impartida en el primer semestre de la carrera de ingeniería de manufactura en la Universidad Tecnológica de Pereira.
Differential Effects of Retinol-Binding Protein 3 and Anti-VEGF Antibodies on Retinal Dysfunctions in Diabetic Retinopathy
Authors: Li Qin , Onizuka Satoru , Park Kyoungmin , Ma Mingming , Fickweiler Ward , Park Hyunseok , Li Qian , Simao Fabricio , Boisclair Jared , Sharawy Maha , Wu I-Hsien , Gregory Yu Marc , P. Aiello Lloyd , K. Sun Jennifer , L. King George
Published: February 2025

Anti-vascular endothelial growth factor (anti-VEGF) therapies are effective treatment of severe diabetic retinopathy (DR) and macular edema, but a significant subset of people showed inadequate response to anti-VEGF intervention. Since elevation or overexpressing retinol binding protein 3 (RBP3) decreased risks for retinal pathologies and progression to severe DR, we compared the therapeutic profile of RBP3 and anti-VEGF to normalize retinal dysfunctions induced by diabetes. Intravitreous injection of recombinant human RBP3 (rhRBP3) and anti-VEGF antibodies (bevacizumab) inhibited retinal vascular permeability in Lewis rats induced by VEGF-A or after 2 months of diabetes induced by streptozotocin, in parallel with reductions of retinal VEGF and VEGFR2 expressions and tyrosine phosphorylation of VEGFR. Only rhRBP3 ameliorated diabetes induced reduction of neural retinal function, measured by electroretinogram. Further, rhRBP3 reduced retinal expressions of inflammatory cytokines (TNFα and IL6) in retinal pigmented epithelial and Müller cells exposed to hyperglycemia. Metabolic studies, using Seahorse, showed only rhRBP3 normalized retinal glycolytic rates in diabetic rats. Thus, both intravitreous anti-VEGF antibodies and RBP3 injections normalized retinal vascular dysfunctions caused by diabetes. Only RBP3 targeted both neural and vascular retina to reduce glycolytic rates, reversed neural-retinal dysfunctions, and reduced inflammatory cytokines induced by diabetes, to delay early changes of DR.
Leveraging Indonesian Values in Educational Service Marketing to Enhance Institutional Image
Authors: Hawu Trisnawati L. Maramba , Ismanto Bambang
Published: February 2025

This study focuses on the issue of ineffective educational service marketing in enhancing the institution's image. The aim of this study is to analyze the implementation of educational service marketing, identify weaknesses in the applied marketing model, and explore aspects of Local Wisdom-Based Educational Service Marketing in improving the institution's image. This research uses a qualitative approach with an ethnographic design. The subjects of the study include the school principal, the vice principal for student affairs, cultural figures, and religious leaders. Data were collected through observations, in-depth interviews, document studies, and focus group discussions (FGD). Data analysis was performed using the model proposed by Miles and Huberman, which consists of three stages: data reduction, data presentation, and data verification. Data validation was conducted using triangulation techniques, including source triangulation and method triangulation. The results of the study indicate that the implementation of educational service marketing in this school has not been effective and has not been maximally executed. Identified weaknesses include the lack of structured marketing activities, insufficient use of local wisdom as an attraction in marketing, and a lack of understanding among school members regarding educational service marketing. Furthermore, local wisdom has not been optimally applied in every aspect of the marketing mix. The conclusion of this study is that efforts need to be made to maximize the implementation of educational service marketing by incorporating local wisdom into every aspect of marketing to enhance the institution's image.
The Dynamics of Community Participation in Establishing a Sustainable School Culture: Exploring the Role of Environmental Values in Adiwiyata Schools
Authors: Santosa Heru , Supadi
Published: February 2025

The role and participation of the school community are pivotal elements in fostering an Adiwiyata School culture based on environmental awareness values. This study aims to describe the roles and participation of the school community in implementing environmental awareness values to establish a sustainable Adiwiyata School culture. The research employed a descriptive qualitative approach, involving teachers, staff, students, and parents as research subjects. Data were collected through semi-structured interviews and document analysis. The findings reveal that the school community successfully supports the implementation of environmental awareness values through various initiatives, such as eco-friendly habits, green infrastructure development, and the integration of environmental awareness values into the curriculum. Active parental participation, combined with proactive efforts from school principals and teachers, emerged as key factors in the program’s success, despite the presence of some challenges. Evaluations conducted by the Environmental Agency and Adiwiyata Task Force members demonstrated the program’s effectiveness in adhering to Adiwiyata standards. These findings reflect the school’s commitment to sustainable environmental education. In conclusion, the roles and participation of the entire school community in implementing environmental awareness values have successfully built a strong, effective, and sustainable Adiwiyata School culture.
Integrating Cultural Values in Nationalism Character Education: A Study on Merdeka Curriculum Implementation
Authors: Wahyudi Ilham , Wuryandani Wuri
Published: February 2025

The character education of nationalism, as outlined in the Merdeka Curriculum, needs to be implemented from an early age, particularly at the elementary school level. However, many teachers still prioritize cognitive assessments over character education. This study aims to explore, analyze, and describe the activities of culture-based nationalism character education conducted by teachers in the classroom. This research employs a qualitative method with data collection through observation, interviews, and documentation. Data analysis is carried out through three stages: data condensation, data presentation, and conclusion drawing. The results indicate that the activities conducted by teachers to foster culture-based nationalism character include four aspects: first, activities to introduce culture; second, activities to appreciate culture; third, interaction across cultural differences; and fourth, reflection on cultural experiences. Can be concluded that the culture-based nationalism character education within the Merdeka Curriculum can thrive through classroom learning, with teachers acting as facilitators who integrate cultural diversity and local wisdom from their respective regions.
Indonesian Cultural Values as Pillars of Academic Resilience: A Study on Indonesian Higher Education Students
Authors: Kaloeti Dian Veronika Sakti , Kurnia S Ayu , Swandi Ni Luh Indah Desira , Lufityanto Galang , Indrawati Nur Diana
Published: February 2025

This study identifies the challenges faced by students in higher education, which require academic resilience to overcome effectively. The study aims to analyze the role of local Indonesian values, such as "gotong royong" (mutual cooperation), "tawakall" (trust in God), and "kesederhanaan" (simplicity), in shaping students' academic resilience. The research method employed is a qualitative approach using focus group discussions, involving 82 undergraduate students from three major cities in Indonesia. Data collection was conducted through guided group discussions that explored students' experiences and perspectives on academic resilience. Data analysis was carried out thematically to uncover the contributions of local values to academic resilience, such as perseverance, adaptability, and problem-solving skills. The findings of the study indicate that local Indonesian values play a crucial role in shaping students' academic resilience by providing a foundation for perseverance and adaptability. The study also discusses the importance of integrating local values into educational practices and research at universities to create a resilient academic environment. The conclusion of this study is that collaborative efforts among university stakeholders are essential to promoting local values in strengthening students' academic resilience.
Music as a Strategy for Character Development in Junior High School
Authors: Sagala Mastri Dihita
Published: February 2025

Music, with its various benefits, can serve as an effective strategy for instilling character values in education. This study examines the strategy applied through music, particularly in singing activities using the song “Mars Gembira Bergerak.” The research is descriptive and adopts a qualitative approach. Data analysis is conducted through the stages of reduction, presentation, and conclusion drawing. Data were collected through observations, interviews, and documentation, including the transcription of the song's notation to understand the lyrics and their meaning. The primary informant in this study is the song's creator. Triangulation techniques were used to evaluate the educational strategy implemented. The findings show that the song contains character values such as responsibility, enthusiasm, independence, creativity, and wisdom. The movements included in the singing activity are also essential for aligning with the character of junior high school students. The implications of this research suggest that teachers should create rhythmic movements in accordance with the music's rhythm. Additionally, the lyrics of the song incorporate the slogan of Bengkayang Regency, which teaches students to raise their thumbs while saying the word “mantap,” making this movement a part of the rhythmic activities that support character learning.
Transforming Higher Education Curriculum Through OBE-Based Semester Learning Plans Integrated with Mpu Kuturan’s Ethical Framework
Authors: Pitriani Ni Rai Vivien , Fitriani Luh Putu Widya , Suseni Komang Ayu
Published: February 2025

Semester Learning Plans (RPS) oriented toward learning outcomes often overlook the development of students' character. In the context of higher education, the Outcome-Based Education (OBE) approach offers a solution by emphasizing clear and measurable learning outcomes, while the character values of Mpu Kuturan can reinforce students' moral and ethical dimensions. This study aims to develop an OBE-based RPS integrated with Mpu Kuturan’s character values to enhance the quality of higher education. This research adopts a Research and Development (R&D) approach using the ADDIE model (Analyze, Design, Develop, Implement, Evaluate). Data were collected through document analysis, interviews with lecturers, and classroom observations. The research subjects included subject matter experts, policy administrators, teaching practitioners (lecturers), and postgraduate students in Hindu Religious Education. The instruments used included questionnaires, and data were analyzed both qualitatively and quantitatively. The findings indicate that developing an OBE-based RPS integrated with Mpu Kuturan’s character values is highly feasible for implementation in the Master’s Program of Hindu Religious Education. The developed RPS not only enhances curriculum relevance but also strengthens students' commitment to academic ethics and increases their engagement in learning. Thus, this approach can serve as an innovative model for designing higher education curricula based on character values and learning outcomes.
Elementary School Science Skills Practical Digital Teaching Module
Authors: Pratiwi Ni Kadek Anggi , I.N Laba Jayanta
Published: February 2025

There is no digital teaching module used in the learning process of elementary science skills to be able to train the ability to learn independently. This research aims to create a valid and practical digital teaching module for elementary school science skills development practice. The research model used is the ADDIE research model. The subjects of this research were 6 experts and 2 practitioners to determine the validity and practicality of the digital module being developed. The object of this research is the validity and practicality of the teaching module. The data collection method used is the questionnaire method. This development research used two data analysis techniques, namely qualitative descriptive analysis techniques and quantitative descriptive analysis techniques. Based on the validity and practicality test analysis, the digital teaching module practice for developing elementary science skills obtained validity from learning material experts at 96.6%, learning design experts at 91.3%, learning media experts at 95.56%, the results of practicality assessments from practitioners of 96%, the practicality assessment in the individual test was 93.3%, and the practicality assessment in the small group test was 95.56%, overall with very good qualifications. The research conclusions of the digital teaching module practice for developing elementary school science skills were declared valid and practical with very good qualifications. This research implies that students can more easily carry out practicums and can learn independently.