bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevention of 90-day Detox Readmission for Opioid Use Disorder by a Community-based Life-changing Individualized Medically Assisted Evidence-based Treatment (C.L.I.M.B.) Program: a Quasi-experimental Design
Authors: Luo Zhehui , Roychoudhury Canopy , LMSW William S. Pompos , DiMaria James , Robinette Cynthia M. , Gore Purva H , Roychoudhury Rohon , Beecroft William
Published: October 2021

Background: Evidence for community-based detox readmission prevention strategies for opioid use disorder (OUD) is scant. We evaluated a pilot program designed to provide individualized and structured treatment plan, including addressing prolonged withdrawal symptoms, family/systems assessment, contingency management, and medically assisted treatment. Methods: A non-randomized quasi-experimental design was used to compare the pilot sites (treatment) and comparison sites before and after the program started, i.e., a simple difference-in-differences (DID) strategy. Adults 18 years and older who meet the Diagnostic and Statistical Manual of Mental Disorders version 5 criteria for OUD and had a detox admission at any facility in two study periods between 5/2018 and 12/2019 are included. Readmission in 90-days after an inpatient detox was the primary outcome. Multiple statistical estimation methods were used to adjust for potential confounding factors between treatment and control groups.Results: A total of 2,320 unique patients with 2,443 index detox admission in the pre- and post-periods were compared. The C.L.I.M.B. patients had higher readmission compared with the controls in the pre-period (unadjusted readmission rates16.4% vs. 10.0%) and similar rates in the post-period (11.8% vs. 10.1%). All DID estimates were not statistically significant (adjusted estimates ranged from 6.0 to 9.2 percentage points difference favoring the C.L.I.M.B. program). Conclusions: While not statistically significant, wrap-around services reduced detox readmission. It may be that the added services helped to inform people that inpatient detox is not necessary for OUD and withdrawal can be managed with a structured treatment plan.
Lactate Metabolism Regulates Tumour Growth and Progression in Glioblastoma
Authors: Longhitano Lucia , Vicario Nunzio , Tibullo Daniele , Giallongo Cesarina , Broggi Giuseppe , Caltabiano Rosario , Barbagallo Giuseppe Maria Vincenzo , Baghini Marta , Rosa Michelino Di , Parenti Rosalba , Giordano Antonio , Mione Maria Caterina , Volti Giovanni Li
Published: October 2021

Background. Tumor microenvironment (TME) plays a pivotal role in establishing malignancy and it is associated with high glycolytic metabolism and increased lactate production accumulating in TME through monocarboxylate transporters (MCTs). Several lines of evidence suggest that lactate also serves as a signalling molecule through its receptor HCAR1thus functioning as a paracrine and autocrine signalling molecule in TME. The aim of the present study was to investigate the role of lactate in glioblastoma (GBM) progression and metabolic reprogramming in an in vitro and in vivo model.Methods. Cell proliferation, migration and clonogenicity assay were performed in vitro on three different human GBM cell lines. Protein expression of MCT1, MCT4 and pharmacological lactate receptor (GPR81) were evaluated both in vitro and in a zebrafish GBM in vivo model. These results were further validated in patient-derived GBM biopsies.Results. Our results showed that lactate significantly increased cell proliferation, migration and colony formation capacity of GBM cells, both in vitro and in vivo. We also showed that lactate increased MCT1 and HCAR1 expression. Moreover, lactate modulated epithelial-mesenchymal transition protein markers E-Cadherin and β-Catenin. Interestingly, lactate induced mitochondrial mass and OXPHOS gene suggesting an improved mitochondrial fitness. Similar effects were observed after treatment with 3,5-Dihydroxybenzoic acid, a known agonist of GPR81. Consistently, GBM zebrafish model exhibited an altered metabolism and increased expression of MCT1 and HCAR1 leading to high levels of extracellular lactate and thus supporting tumor cell proliferation. Our data from human GBM biopsies also showed that in high proliferative GBM biopsies, Ki67 positive cells expressed significantly higher levels of MCT1 compared to low proliferative GBM cells.Conclusions. Our data suggest that lactate favours proliferation of neighbourhood cells by cooperating with their glycolytic metabolism, sensing and removing extracellular lactate. In particular, lactate and its transporter and receptor play a major role in GBM proliferation and migration thus representing a potential target to develop new strategies to counteract tumor progression and recurrencies.
Reprogramming of arachidonate metabolism confers drug resistance to glioblastoma through Enhancing Mitochondrial Activity in Fatty Acid Oxidation
Authors: Tsai Yu-Ting , Lo Wei-Lun , Chen Pin-Yuan , Ko Chiung-Yuan , Kao Tzu-Jen , Yang Wen-Bing , Chang Kwang-Yu , Hung Chia-Yang , Kikkawa Ushio , Chang Wen-Chang , Hsu Tsung-I
Published: October 2021

Background

Sp1 is involved in the recurrence of glioblastoma (GBM) due to the acquirement of resistance to temozolomide (TMZ). Particularly, the role of Sp1 in metabolic reprogramming for drug resistance remains unknown.
Methods

RNA-Seq and mass spectrometry were used to analyze gene expression and metabolites amounts in paired GBM specimens (primary vs. recurrent) and in paired GBM cells (sensitive vs. resistant). ω-3/6 fatty acid and arachidonic acid (AA) metabolism in GBM patients were analyzed by targeted metabolome. Mitochondrial functions were determined by Seahorse XF Mito Stress Test, RNA-Seq, metabolome and substrate utilization for producing ATP. Therapeutic options targeting prostaglandin (PG) E2 in TMZ-resistant GBM were validated in vitro and in vivo.
Results

Among the metabolic pathways, Sp1 increased the prostaglandin-endoperoxide synthase 2 expression and PGE2 production in TMZ-resistant GBM. Mitochondrial genes and metabolites were obviously increased by PGE2, and these characteristics were required for developing resistance in GBM cells. For inducing TMZ resistance, PGE2 activated mitochondrial functions, including fatty acid β-oxidation (FAO) and tricarboxylic acid (TCA) cycle progression, through PGE2 receptors, E-type prostanoid (EP)1 and EP3. Additionally, EP1 antagonist ONO-8713 inhibited the survival of TMZ-resistant GBM synergistically with TMZ.
Conclusion

Sp1-regulated PGE2 production activates FAO and TCA cycle in mitochondria, through EP1 and EP3 receptors, resulting in TMZ resistance in GBM. These results will provide us a new strategy to attenuate drug resistance or to re-sensitize recurred GBM.
Summer Regional Climate Simulations Over Tibetan Plateau at Gray-Zone and Convection-Permitting Scale
Authors: Ma Mengnan , Ou Tinghai , Liu Dongqing , Wang Shuyu , Fang Juan , Tang Jianping
Published: October 2021

The Tibetan Plateau (TP) is often referred to as ‘the Third Pole’ and plays an essential role in influencing the global climate. However, it remains challenging for most global and regional models to realistically simulate the characteristics of long-period climate over the TP. In this study, two Weather Research and Forecasting model (WRF) experiments using the regional climate simulation method of spectral nudging with gray-zone (GZ9) and convection-permitting (CP3) resolution are conducted for summer from 2009 to 2019. The surface air temperature (T2m) and precipitation are evaluated against in-situ observations and the Global Satellite Mapping of Precipitation (GSMaP) dataset. The results show that both experiments can successfully capture the spatial pattern and daily variation of T2m and precipitation, though cold bias for temperature and dry bias for precipitation exist especially over the regions south of 35ºN. Compared to GZ9, CP3 reduces the cold and dry bias over the southern TP. In addition, analysis of the diurnal variation of precipitation shows that both experiments simulate the advanced occurrence time of maximum precipitation by about 3 hours over the eastern TP but postpone the occurrence time of maximum precipitation over the central and western TP. Both experiments simulate a bimodal structure of the diurnal cycle of precipitation amount (PA). Further investigation reveals that GZ9 has more low-level clouds and prevents shortwave radiation from reaching the surface during daytime, leading to lower maximum surface air temperature (Tmax) in GZ9, while CP3 has more low-level clouds over the southeastern TP and preventing the outgoing longwave radiation and compensating the heat loss during nighttime, resulting in higher minimum surface air temperature (Tmin) in CP3. Besides, more water vapor over the southeastern TP results in more precipitation and thus reduced dry bias in CP3 over the southeastern TP. Moreover, the current study also indicates that gray-zone scale simulations can perform as good as convection-permitting simulations by carefully choosing the right parameterization schemes.
PIK3CA Mutation Correlates With mTOR Pathway Expression But Not Clinical and Pathological Features in Fibro-Adipose Vascular Anomaly (FAVA)
Authors: Hori Yumiko , Hirose Katsutoshi , Ozeki Michio , Hata Kenji , Motooka Daisuke , Tahara Shinichiro , Matsui Takahiro , Kohara Masaharu , Higashihara Hiroki , Ono Yusuke , Tanaka Kaishu , Toyosawa Satoru , Morii Eiichi
Published: October 2021

BackgroundFibro-adipose vascular anomaly (FAVA) is a rare and new entity of vascular anomaly. Activating mutations in the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) gene were identified at a frequency of 62.5% in FAVA cases. The PIK3CA mutations excessively activate mammalian target of rapamycin (mTOR) pathway, which promotes angiogenesis and lymphangiogenesis, implying that PIK3CA mutations may act as drivers of FAVAs. This study investigated the correlations between PIK3CA mutational status, clinicopathological features and immunohistochemical expression of the mTOR pathway in a series of FAVA.MethodsWe retrospectively evaluated the clinical and pathological findings of five FAVA cases. We performed next-generation sequencing (NGS) with a custom panel of genes associated with the mTOR pathway and genes responsible for other vascular anomalies, direct sequencing and immunohistochemical analysis of the mTOR pathway.ResultsTwo PIK3CA-mutation cases and three PIK3CA-wild-type (wt) cases exhibited similar typical clinical features of FAVA. Histological analysis revealed venous malformation, lymphatic malformation, nerves containing enlarged abnormal vessels and fibrofatty tissue were observed regardless of PIK3CA mutational status. In contrast to clinical and histological findings, the immunohistochemical expression of activated AKT and mTOR that are upstream of the mTOR pathway was detected in abnormal vessels of PIK3CA-mutation cases but not in those of PIK3CA-wt cases. However, activated eukaryotic translation initiation factor 4E-binding protein 1 (4EBP1) and ribosomal protein S6 kinase 1 (S6K1), both of which are downstream effectors of the mTOR pathway, were expressed in abnormal vessels of both PIK3CA-mutation and PIK3CA-wt cases. Furthermore, targeting NGS did not find any common genetic mutations involved in the mTOR pathway among PIK3CA-wt cases.ConclusionThere was no significant association between the presence of PIK3CA mutations and the clinicopathological features of FAVA, suggesting that the PIK3CA gene is not necessarily involved in the onset of FAVA. FAVAs lacking PIK3CA mutations would be caused by other gene mutations that activate 4EBP1 and S6K1.
Competing at the Cybathlon Championship for Athletes With Disabilities: Long-Term Motor Imagery Brain-Computer Interface Training of a Tetraplegic Cybathlete
Authors: Korik Attila , McCreadie Karl , McShane Niall , Du Bois Naomi , Khodadadzadeh Massoud , Stow Jacqui , McElligott Jacinta , Carroll Áine , Coyle Damien
Published: October 2021

Background: The brain-computer interface (BCI) race at the Cybathlon championship for athletes with disabilities challenges teams (BCI researchers, developers and pilots with spinal cord injury) to control an avatar on a virtual racetrack without movement. Here we describe the training regime and results of the Ulster University BCI Team pilot who is tetraplegic and has trained to use an electroencephalography (EEG)-based BCI intermittently over 10 years, to compete in three Cybathlon events. Methods: A multi-class, multiple binary classifier framework was used to decode three kinesthetically imagined movements (motor imagery) (left (L) and right (R) arm and feet (F)) as well as relax state (X). Three games paradigms were used for training i.e., NeuroSensi, Triad, and Cybathlon: BrainDriver. An evaluation of the pilot’s performance is presented for two Cybathlon competition training periods – spanning 20 sessions over 5 weeks prior to the 2019 competition, and 25 sessions over 5 weeks in the run up to the 2020 competition.Results: Having participated in BCI training in 2009 and competed in Cybathlon 2016, the experienced pilot achieved high two-class accuracy on all class pairs when training began in 2019 (decoding accuracy >90%, resulting in efficient NeuroSensi and Triad game control). The BrainDriver performance (i.e., Cybathlon race completion time) improved significantly during the training period, leading up to the competition day, ranging from 274s - 156s (255±24s to 191±14s mean±std), over 17 days (10 sessions) in 2019, and from 230s - 168s (214±14s to 181±4s), over 18 days (13 sessions) in 2020. However, on both competition occasions, towards the race date, the performance deteriorated significantly.Conclusions: The training regime and framework applied were highly effective in achieving competitive race completion times. The BCI framework did not cope with significant deviation in electroencephalography (EEG) observed in the sessions occurring shortly before and during the race day. Stress, arousal level and fatigue, associated with the competition challenge and performance pressure resulting in cognitive state changes, were likely contributing factors to the nonstationary effects that resulted in the BCI and pilot achieving suboptimal performance on race day. Trial registration: not registered
Mental Health Stigma at Primary Health Care Centres in Lebanon: Qualitative Study
Authors: Hana Racha Abi , Arnous Maguy , Heim Eva , Aeschlimann Anaïs , Koschorke Mirja , Hamadeh Randa S. , Thornicroft Graham , Kohrt Brandon A. , Sijbrandij Marit , Cuijpers Pim , Chammay Rabih El
Published: October 2021

Background Mental health related stigma is a global public health concern and is considered a major barrier to seeking care. In this study, we explored the role of stigma as a barrier to scaling up mental health services in primary health care (PHC) centres in Lebanon. We focused on the experiences of PHC workers, while providing services to patients with mental disorders, and the perceptions of stigma or discrimination among individuals with mental illness and their families. This study was part of a larger multinational stigma reduction programme, called INDIGO-PRIMARY.Method Semi-structured qualitative interviews (n=46) were carried out, with policy makers (n=3), PHC management (n=4), PHC staff (n=24), service users and family members (n=15). The topic guides explored knowledge, implicit and explicit attitudes of staff, challenges of providing treatment, and patient outcomes including experiences of stigma. All interviews were coded using NVivo and analysed using a thematic coding framework.Results Results were analysed at five stigma-related layers: from structural stigma at the system level, down to provider-based stigma at PHC level, community level stigma, family stigma and self-stigma. Interestingly at the PHC level, stigma reporting differed among staff according to a power gradient. Service users described positive experiences in PHC. Nurses and social workers did not explicitly report incidents of stigma or discrimination but describing patients with mental health disorders as violent or uncooperative, underscored internalized negative views on mental health. GPs and directors were more outspoken than nurses regarding the challenges faced when dealing with mental health patients. Nevertheless, mental health professionals reported that things have been getting increasingly better over recent years.Conclusions This qualitative study revealed that stigma was still a major concern that affects patients with mental disorders and provided a deeper understanding on what should be done to decrease stigma at PHC centres; first addressing structural stigma by revising laws, second shaping interpersonal stigma, third commitment of PHC management to deliver high quality mental health integrated services, and fourth addressing intrapersonal stigma by building public empathy.
Lard-Blended Vegetable Oil Diet Alleviates Metabolic Syndrome in Mice
Authors: Yan Sisi , Qu Jianyu , Liu Xiangyan , Liu Sha , Zeng Yu , Zhou Huijuan , Matias Froilan Bernard , Wen Lixin , Wang Ji
Published: October 2021

Background: Our previous work has suggested that the balance fatty acid diet, blending lard with soybean oil, could reduce adipose tissue accumulation by decreasing adipogenesis and lipogenesis while increasing the hydrolysis of triglycerides. The aim of present study is to investigate whether the fat reducing function of balanced fatty acid diet extended to sunflower oil, and explore its effects on liver lipids metabolism and insulin resistance.Methods: 50 mice were divided into 5 groups, fed with lard, sunflower oil, soybean oil, mixture of lard and sunflower oil, and mixture of lard and soybean oil for 12 weeks separately.Results: Results showed that a mixture of lard and vegetable oil (sunflower oil and soybean oil), particularly a mixture of lard and soybean oil decreased body weight, body fat rate, liver triglyceride level compared to lard, sunflower oil, and soybean oil, a mixed oil also decreased serum triglyceride and free fatty acid levels compared to lard diet. Further analysis indicated that activation of the AMPK pathway contributes to these observed phenotypes, and co-upregulated of glucagon and GLP-1 in mice fed with mixture of lard and soybean oil may contribute to improved lipids metabolism. Conclusion: Moderate lard intake—blended lard with vegetable oil especially soybean oil—has the potential to alleviate metabolic syndrome via activating AMPK pathway and co-upregulated of glucagon and GLP-1.
Shrub encroachment stabilizes aboveground biomass and enhances community diversity in alpine meadow of the Hengduan Mountain, Southwest China
Authors: zeng fang , Wang Genxu , Yang Yang , Yang Kai , Tang Chuanchuan , Tan Xiangjiao , Jiang Yong , Yang Yan , Zhao Xiaoxiang
Published: October 2021

Aims

To understand the response of alpine meadow to shrub encroachment, we analyzed alpine meadow plant community structure and function and soil properties at different shrub coverage sites in western Sichuan, P.R. China, further providing a reasonable scientific basis to better control or remove the effects of shrub encroachment on local meadow.
Methods

A site with an area of 200 × 200 m along the shrub line was selected as the study area (4300 m a.s.l.) in Yajiageng Valley, Hengduan Mountain, Southwest China. The study area was divided into four treatments. Control, low-, medium- and high -shrub- coverage plots were investigated for community composition, above- ground biomass and belowground biomass were harvested, and root functional traits and soil properties were measured in laboratory in the summer of 2020.
Results

There was no significant difference in the total aboveground biomass among all treatments, however, forb and legume biomass increased, and grass and sedge biomass decreased with increased shrub coverage; Species richness significantly decreased, but diversity and evenness index increased in the medium -shrub -coverage plots; Root biomass at the depth of both 0-10 cm and 10-20 cm significantly decreased in medium- and high -shrub -cover plots; The field capacity, soil total nitrogen (STN) and available nitrogen (AN) concentration were significantly decreased in the medium -shrub -coverage plots, and the total phosphorus (TP) concentration were significantly decreased among all treatments.
Conclusion

The process of shrub encroachment tends to limit the local dominant species and maintain the growth of nondominant species, which further increases the community diversity and maintains the stability of aboveground biomass. Shrub encroachment makes alpine meadow soil became drier and impoverishment and promoted the mineralization of organophosphorus and the dissolution of insoluble inorganic phosphorus, which strengthened the alpine ecosystem nitrogen (N) limit.
Neutron's basic Mass
Authors: geilhaupt manfred
Published: October 2021

In Quantum Physics the Spin of an elementary particle is defined to be an „intrinsic, inherent“ property. The same to the magnetic moment (μ) due to the spin of charged particles - like Electron (me) and Muon (mu). So the intrinsic spin (S) of the electron entails a magnetic moment. However, a magnetic moment of a charged particle can also be generated by a circular motion of an electric charge (e), forming a current. Hence the „orbital motion of charge“ around a „mass-nucleus“ generates a magnetic moment by Ampère’s law. This concept leads to an alternative way calculating the neutrino mass (mν) while discussing the beta decay of a neutron into fragments: proton, electron, neutrino and kinetic energy - now based on the change of magnetic moments during the process. This alternative calculation gives mν = 0.10(20)eV.
Resource Allocation Strategy of Internet of Vehicles Using Reinforcement Learning in Edge Computing Environment
Authors: li Yihong , liu Zhengli , Tao Qi
Published: October 2021

Because the traditional computing model can no longer meet the particularity of Internet of Vehicles tasks, aiming at its characteristics of high bandwidth, low latency and high reliability, this paper proposes a resource allocation strategy for Internet of Vehicles using reinforcement learning in edge cloud computing environment. First, a multi-layer resource allocation model for Internet of Vehicles is proposed, which uses the cooperation mode of edge cloud computing servers and roadside units to dynamically coordinate edge computing and content caching. Then, based on the construction of communication model, calculation model and cache model, make full use of idle resources in Internet of Vehicles to minimize network delay under the condition of limited energy consumption. Finally, the optimization goal is solved by two-layer deep Q network model, and the best resource allocation plan is obtained. The simulation results based on the Internet of Vehicles model show that the computational energy consumption and system delay of proposed strategy do not exceed 400J and 600ms respectively. Besides, the overall effect of resource allocation is better than other comparison strategies and it has certain application prospects.
A Method of Identifying Geometric Errors For Machine Tools With 3 Axes Based On a Set of Sine Functions Using Double Ballbar
Authors: Chen Guangsheng , ZHANG Yue , YUAN Bu
Published: October 2021

Geometric error is an important error source of machine tools. Quick, accurate and convenient measurement of machine tool geometric errors is an urgent need to improve the accuracy of machine tools. Based on the ballbar's circular trajectory test principle, this paper proposes a machine tool error identification method based on a collection of sine functions. Based on the multi-body system theory and the homogeneous coordinate transformation method, a mathematical model of the circular path error and geometric error of the machine tool with 3 axes is established. Using a collection of sine functions to fit geometric errors has a higher fitting accuracy than traditional polynomial function fitting methods. By designing five circular motion trajectories of the same radius with different centers in the test area, and assuming that each geometric error is a collection of sine functions, a parametric model identification model for machine tool geometric errors based on the circular trajectory is derived. The particle swarm algorithm is used to search and solve the various parameters of the sine function collection, and finally 9 linear errors and 5 angular errors of the machine tool are obtained. In order to verify the effectiveness of the method, simulation and test comparison experiments were carried out. The experimental results show that 4 linear errors and 1 angular error of the machine toolscan be effectively obtained. The verification experiment results show that, compared with the measurement results of the laser interferometer, the maximum deviation of the measurement and identification results proposed in this paper is within 2.5 μm.
Coverless Image Steganography Using Morphed Face Recognition based on Convolutional Neural Network
Authors: Li Yung-Hui , Chang Ching-Chun , Su Guo-Dong , Yang Kai-Lin , Aslam Muhammad Saqlain , Liu Yanjun
Published: October 2021

In recent years, information security has become a prime issue of worldwide concern. To improve the validity and proficiency of the image data hiding approach, a piece of state-of-the-art secret information hiding transmission scheme based on morphed face recognition is proposed. In our proposed data hiding approach, a group of morphed face images is produced from an arranged small-scale face image dataset. Then, a morphed face image which is encoded with a secret message is sent to the receiver. The receiver uses powerful and robust deep learning models to recover the secret message by recognizing the parents of the morphed face images. Furthermore, we design two novel Convolutional Neural Network (CNN) architectures (e.g. MFR-Net V1 and MFR-Net V2) to perform morphed face recognition and achieved the highest accuracy compared with existing networks. Additionally, the experimental results show that the proposed schema has higher retrieval capacity and accuracy and it provides better robustness.
Predictive nomogram for unfavorable outcome of spontaneous intracerebral hemorrhage
Authors: Liu Mingxing , Wang Zijun , Meng Xiankun , Zhou Yong , Hou Xiaoqun , Li Luo , Li Tong , Chen Feng , Xu Zhiming , Li Shengli , Wang Weimin
Published: October 2021

Background and purpose

Introduction The goal of this study was to retrospectively identify potential risk factors, especially surgical timing, for poor prognosis of ICH.
Methods

Medical records of ICH cases who had undergone surgery between January 2014 and January 2021 were reviewed. The modified Rankin Scale score (MRS) were assigned to ICH subjects at 6 months after attack. The relationships of surgical timing with the risk of unfavorable outcome were identified using the interaction and stratified analyses, generalized additive and logistic regression model. Depending on the results of logistic regression, a nomogram was established and evaluated using a receiver operating characteristic curve analysis, plotted decision curve and calibration curve.
Results

Finally, 53 and 144 cases were enrolled into the favorable and unfavorable outcome group respectively. The cases who underwent surgery at >12h and <36h in the favorable outcome group were more than that in the unfavorable outcome group (p<0.001). When the time to operation room (TOR) was less than 21h, the negative association between TOR and unfavorable outcome was observed in the smoothing spline (OR=0.8, p < 0.001). We developed a nomogram including SBP, GCS, midline shift, hematoma volume and TOR for predicting the unfavorable outcome. The AUC, accuracy, specificity, and sensitivity of nomogram were 0.90, 0.87, 0.72, 0.93 respectively.
Conclusions

The patients who underwent surgery at >12h and <36h were more likely to get favorable outcome. The nomogram including SBP, GCS, midline shift, hematoma volume and TOR was reliable for predicting ICH outcome.
Evaluating Plant Breeding Strategies by Simulating Gene Action and Dryland Environment Effects
Authors: Chapman Scott , Cooper Mark , Podlich Dean , Hammer Graeme
Published: October 2021

Functional genomics is the systematic study of genome‐wide effects of gene expression on organism growth and development with the ultimate aim of understanding how networks of genes influence traits. Here, we use a dynamic biophysical cropping systems model (APSIM‐Sorg) to generate a state space of genotype performance based on 15 genes controlling four adaptive traits and then search this space using a quantitative genetics model of a plant breeding program (QU‐GENE) to simulate recurrent selection. Complex epistatic and gene × environment effects were generated for yield even though gene action at the trait level had been defined as simple additive effects. Given alternative breeding strategies that restricted either the cultivar maturity type or the drought environment type, the positive (+) alleles for 15 genes associated with the four adaptive traits were accumulated at different rates over cycles of selection. While early maturing genotypes were favored in the Severe‐Terminal drought environment type, late genotypes were favored in the Mild‐Terminal and Midseason drought environment types. In the Severe‐Terminal environment, there was an interaction of the stay‐green (SG) trait with other traits: Selection for + alleles of the SG genes was delayed until + alleles for genes associated with the transpiration efficiency and osmotic adjustment traits had been fixed. Given limitations in our current understanding of trait interaction and genetic control, the results are not conclusive. However, they demonstrate how the per se complexity of gene × gene × environment interactions will challenge the application of genomics and marker‐assisted selection in crop improvement for dryland adaptation.
Tecnologías de la información y la comunicación en educación: Impactos y desafíos
Authors: Alvites Huamaní Cleofé Genoveva
Published: October 2021

La sociedad a nivel global ha sufrido de cambios abruptos por la pandemia (Hernández, 2020) que ha azotado en todos los continentes, aunque todavía se sigue enfrentando a las nuevas variantes del coronavirus, pero a pesar de ello se ha tenido que retomar actividades tanto económicas, laborales y educativas, (Brítez, 2020) debido a que muchas de las restricciones se han ido levantando, dando paso a una nueva normalidad.
Capstone Design en los Programas de Ingeniería: Una Revisión Sistemática
Authors: Urrea Merchán Camilo Andrés , Duque Mogollón Johann Alberto , Vásquez González Edelberto
Published: October 2021

Los programas de ingeniería reconocen cada vez más la importancia de incluir en sus currículos, cursos de experiencias de diseño (Capstone Design, por sus términos en inglés) como estrategia formadora y enriquecedora para los futuros profesionales. El presente estudio identificó la evolución de este tipo de cursos en el período comprendido entre 1989 y 2020. Para ello, se realizó una revisión de 33 artículos publicados en SCOPUS. Se analizaron seis lustros con la ayuda de la herramienta VOSviewer para la identificación de temas concurrentes y emergentes. Los resultados mostraron que, los cursos “Capstone Design”, independientemente de la disciplina en la cual se apliquen, tienen como objetivo brindar herramientas para que los estudiantes afronten un reto profesional aplicado.
WhatsApp como recurso educativo y tecnológico en la educación
Authors: Cervantes Rosas Charo Mimi , Alvites-Huamaní Cleofé Genoveva
Published: October 2021

En este estudio se hace una revisión documental del WhatsApp en el ámbito educativo en las bases de datos de SCOPUS, WOS y Scielo, Cybertesis, encontrándose un total de 101 documentos. Después de considerar los criterios de inclusión y exclusión, la muestra documental quedo conformada por 35 artículos, que fueron analizados desde una perspectiva teórico-conceptual para conocer cómo se originó y evolucionó el WhatsApp como es usado como recurso tecnológico; qué funcionalidades tiene como recurso educativo y cuáles son sus ventajas y desventajas en la educación.
Risk Management of Training Services in PT MMK
Authors: Sofi Bovi Mutiara , Mulyati Heti , Soeboer Deni Achmad
Published: October 2021

One of the business training services that is rapidly grown is at the Occupational Health and Safety (Keselamatan dan Kesehatan Kerja (K3)) training services. PT MMK is a K3 training service company that has been developed since 2016. However, PT MMK faces some risks in its business activities. There are various problems and potential risks faced by PT MMK, so it needs a business risk management observation. The research aimed to identify and analyze the level of risk faced by PT MMK by applying a quantitative method. The primary and secondary data were used. Sampling was carried out by using non-probability techniques with purposive sampling through the expert judgment approach. There were eight respondents in the research. Meanwhile, the applied analytical methods were Cochran analysis and Godfrey risk map. The result shows that based on four divisions, PT MMK has 30 internal risks and 8 external risks. There are 4 low-level risks, 14 moderate-level risks, 19 high-level risks, and 1 extreme-level risk. Based on the highest risks, PT MMK should do detailed budgeting, so there is no over cost based on the previous training budget. Moreover, the company can also expand its market share to the other companies by offering its training.
Demographical Analysis and Cultural Characteristic to Attract Japanese Tourists to Indonesia
Authors: Asthu Agita Arrasy , Putra William Kalua
Published: October 2021

Japan is one of the biggest international tourist contributors to Indonesia. However, in recent years, there is a negative growth. It is caused by the demographical change of the Japanese population and outbound. Hence, research about the cultural ethnicity and social conditions affecting international travelers' behavior in tourism activities is needed. The research focused on the segmentation and strategies to attract foreign tourist which Indonesia would carry. The applied research method was a qualitative descriptive approach that utilized secondary data, such as demographical data and cultural characteristics. Data were taken from the Central Bureau of Statistics of the Republic of Indonesia, Ministry of Tourism and Creative Economy of the Republic of Indonesia, World Bank, and Statistics Bureau of Japan. Then, those data were analyzed by a descriptive statistics method. The result intends to formulate a strategy to seek more potential tourist growth from a Japanese market. The result shows four strategic efforts that Indonesia can take to maximize the potential for the arrival of foreign tourists from Japan. The government can consider the increased number of “silver age” and adult female workers (Joshitabi), which dominate the travelers’ segment to Indonesia, and pay attention to air connectivity and unique cultural characteristic of Japan.
Investigating Brand Switching on Cosmetics Products: A Case Study of Nu Skin
Authors: Ajiwinanto Mayong , Simanjuntak Megawati , Tanjung Hendri
Published: October 2021

The rapid development of the cosmetics industry and the high competition in the cosmetics market in Indonesia impact consumers. The market has many available choices of cosmetics products, and this situation causes many consumers to switch brands. The research aimed to analyze the suitability of Sharia about cosmetics products from Nu Skin and the factors that influenced the brand switching of the cosmetics product with multi-level marketing. The research applied a quantitative and descriptive approach. Data collection from respondents was carried out with a structured questionnaire. The respondents were consumers who had bought and used Nu Skin products. Around 150 respondents were selected through the purposive sampling method. Then, the researchers used the LISREL software. The connection between the variables was investigated by Structural Equation Modeling (SEM). The ﬁndings indicate that Word of Mouth (WOM) and marketing mix significantly influence the brand image of the cosmetics products. Similarly, religiosity and marketing mix have a significant influence on brand attitude. Then, brand image and brand attitude have a significant effect on brand switching. However, religiosity has no significant effect on brand switching. For marketing practitioners, the results can be considered in terms of marketing strategy in consumers’ habits of accessing social media to read product reviews from their friends who have used Nu Skin products before. The more people review and recommend the products to others, the higher the consumers’ interest is in buying Nu Skin products, and the smaller the intensity is involved in brand switching behavior. The research offers a new insight regarding the inﬂuencing factors of brand switching of halal cosmetics products through multi-level marketing.
The Role of Omnichannel and Experiential Marketing to Build Brand Association in ZAP Clinic
Authors: Alfina Alfina , Khoirina Marisya Mahdia , Ulya Muwahiddatul
Published: October 2021

The development of online commerce, popularly known as online stores, has rapidly changed people's lifestyles. Lately, online shopping trends do not mean that offline stores are no longer prioritized, especially in beauty clinics that sell their services and products. ZAP Clinic Indonesia is a beauty clinic focusing on offline and online sales to increase the company's brand equity. The research aimed to determine and analyze the effect of omnichannel and experiential marketing on brand association using the Customer-based Brand Equity (CBBE) method. The research applied a quantitative approach with a sample size of 101 respondents. The respondents were the consumers who had visited and tried the services and products of ZAP Clinic in Surabaya. The sampling technique was accidental sampling with a questionnaire as the instrument. Then, data were analyzed using the multiple regression analysis method to determine whether omnichannel and experiential marketing affected the brand association at ZAP Clinic. The results show that omnichannel and experiential marketing have a positive effect on brand association. Experiential marketing has a dominant value to create a stronger positive association. Moreover, omnichannel will boost the creation of brand association about ZAP Clinic through the marketing campaigns and delivering new experiences related to technology usage in skincare treatment.
Significant Other’s Anticipated Emotions Increase Student’s Intention to Avoid Smoking
Authors: Simamora Bilson
Published: October 2021

This research started with the premise that individuals could take the initiative and regulate their behavior to generate Significant Others’ Anticipated Emotions (SOAEs). Could the SOAEs function as a social element of behavior in addition to subjective norms (SN)? This research aimed to answer this question. Therefore, the researcher extended the Theory of Planned Behavior (TPB) and argued that the SOAEs influenced behavioral intention through attitude toward behavior based on cognitive balance theory. In the smoking abstinence behavioral context, the researcher tested the extended model. The data from 242 respondents chosen conveniently, analyzed using structural equation modeling, revealed that significant others’ anticipated joyfulness (SOAJ) for smoking abstinence behavior and significant others’ anticipated distress (SOAD) for smoking behavior positively influences anti-smoking behavior through attitude. Moreover, the sole influence of the SOAJ and cumulative influence of SOAJ and SOAD on smoking abstinence intention are higher than that of the SN. As a new component of TPB, the SOAEs complement and do not rival the SN. Other researchers can utilize a longitudinal research design and test the extended model in different contexts of behaviors.
Multicultural Competence Awarness Among International Students in Yogyakarta State University
Authors: Romano Galindo Edith , Andriyanti Erna
Published: October 2021

This research aimed to describe and interpret the characteristics of multicultural awareness of seven international students studying tertiary education in the postgraduate studies department at Yogyakarta State University. When individuals moved to a place where more than one culture coexists, they were now part of a multicultural society. In this respect, one of the many reasons for the existence of multicultural societies was the student mobility phenomenon in which many students decided to live abroad to pursue their academic goals. Accordingly, these students faced new cultural situations, and there was no doubt that they needed to use their multicultural competencies. However, were they aware of their own multicultural competence? Had the way they conceptualized it ever helped them to achieve their professional goals? In the present research, such questions highlighted the relevance of focusing on the existing knowledge about multicultural competence of international students, which might provide insights into the role of multicultural competence as an inherent aspect of life to achieve personal or professional goals and strengthen their intercultural communication. Many pieces of research have already focused on the teachers’ multicultural competence and the importance of incorporating it in the programs. However, not many of them focused on the way students conceptualized it and perceived it in their lives. By using qualitative research and making use of a questionnaire as the main instrument, the findings show that students have a high level of awareness, and they mostly conceive it as a tool to achieve their professional goals.
Hydrus-1D simulation of two-stage cross-flow pre-filtration of turbid river water
Authors: Davis Goldie , Ekwue Edwin
Published: October 2021

Simulation is a modus operandi often used for imitating real-world processes. It involves a system and set of assumptions used for computing a numerical model, from which the outcome is an estimate of the true characteristics of how the system behaves. The intention of this research was to investigate the efficiency of fabric in two-stage cross-flow filtration using linen, crepe-backed satin, burlap and cotton fabric filter media. The results from previous pilot-scale experiments performed showed that linen fabric was the most effective medium at retaining particles. In continuation of this research, the aim of this paper was to utilize Hydrus-1D simulation software to simulate cross-flow filtration with fabric filter medium. This was done to further confirm the efficiency of cross-flow filtration, in particular with linen fabric filter media. Simulation entailed investigating fabric water content versus pressure head; bottom pressure head versus time; fabric water storage versus time; and cumulative infiltration versus time with both single and four layers of fabric filter media. Hydrus-1D simulation was productive since it confirmed that cross-flow filtration with linen fabric filter media has the potential of becoming a pre-filtration step in surface water treatment, further adding to the results obtained from previous pilot-scale experiments.
İlkokul Dördüncü Sınıf Öğrencilerinin Okuma Motivasyonlarını Etkileyen Faktörlere İlişkin Görüşleri
Authors: KARAKULLUKCU Nurullah , ÇELİK Yaşar
Published: October 2021

Okuma, bireylerin günlük yaşamında kullandıkları temel becerilerden biridir. Okuma göz, ses ve beynin ‎çeşitli fonksiyonlarının birlikte çalıştığı karmaşık bir süreçtir. Yapılan araştırmalarda, öğrencilerin okuma düzeylerinin az olduğu ve bu nedenle de öğretim programlarında okumaya önem verilmesi gerektiği belirtilmektedir. Bu araştırma ilkokul 4. sınıf öğrencilerinin okuma motivasyonlarını etkileyen faktörlere ilişkin görüşlerini belirlemek amacıyla yapılmıştır. Araştırma Samsun İl MEM’e bağlı devlet okullarında 2013-2014 eğitim-öğretim yılında öğrenim gören 986 ilkokul 4. sınıf öğrencisi üzerinde gerçekleştirilmiştir. Araştırmanın örneklemi oranlı küme örnekleme yöntemiyle belirlenmiş ve uygulama için gidilen okullar rastgele belirlenmiştir. Araştırmada ölçme aracı olarak 35 maddelik “İlkokul Öğrencilerinin Okumaya Güdüleyen Faktörlere İlişkin Görüşlerini Belirleme Anketi” kullanılmıştır. Verilerin analizlerinde frekans ve yüzde değerleri kullanılmıştır. Araştırmanın sonuçlarına göre, öğrencilerin okuma motivasyonları öğretmenler ve kitaplar tarafından daha sık etkilenmekte iken, aile ve arkadaşların daha az etkilediği belirlenmiştir. Ayrıca araştırmada kitap seçiminde en önemli unsurun kitabın konusu olduğu, tavsiye edilen kitapların ilgi alanlarına uygun olduğu, kitapların arkadaşlar arasında değiştirilerek okunduğu ifade edilmiştir.
Fen Bilimleri Öğretmen Adaylarının Derste Teknoloji Kullanımına Yönelik Eğilimleri
Authors: ÇELİK Cüneyd , ÇELİK Büşra , ALPASLAN Muhammet Mustafa
Published: October 2021

Bu çalışma, fen bilimleri öğretmeni adaylarının derste teknoloji kullanımına yönelik eğilimlerini ortaya çıkarmayı amaçlamaktadır. Araştırma, karma yöntem desenlerinden yakınsak karma desen ile yürütülmüştür. Nicel verilerin toplandığı çalışma grubunu fen bilgisi öğretmenliği programında okuyan 88 öğrenci oluşturmaktadır. Nicel veri toplama aracı olarak Derste Teknoloji Kullanımına Yönelik Eğilim Ölçeği kullanılmıştır. Bu ölçek, 2 boyutlu 16 maddeden oluşan bir ölçme aracıdır. Nitel verilerin toplandığı çalışma grubunu ise nicel araştırmaya katılmayan öğretmen adayları arasından seçilen 11 kişi (1. sınıf 6 kişi; 4. sınıf 5 kişi) oluşturmaktadır. Nitel verilerin toplanması, öğretmen adaylarının teknolojiyi derste kullanmaya yönelik görüşlerini ortaya çıkartmayı amaçlayan yarı-yapılandırılmış görüşme ile yapılmıştır. Elde edilen nicel bulgulara göre öğretmen adaylarının derste teknoloji kullanmaya yönelik duyuşsal eğilimleri davranışsal eğilimlere göre daha yüksek olduğu ortaya çıkmıştır. Yine hem nicel bulgular hem de nitel bulgular, 4. sınıf öğretmen adaylarının derste teknoloji kullanmaya yönelik eğilimlerinin 1. sınıflara göre daha yüksek olduğunu göstermektedir.