bluuebunny/crossref_metadata_2025 huggingface dataset:
Does e-banking moderate customer value relations with corporate reputation: The case of BNI bank in Kediri city, Indonesia
Authors: Lidiawan Angga Rizka , Ujianto  , Cempena Ida Bagus
Published: May 2023

Banking activities that utilize internet media to support banking services and at the same time carry out online transactions using communication media have proven to be profitable and make it easier for customers to make transactions. The purpose of this study is to analyze whether e-banking moderates the relationship between customer value and corporate reputation and examine the effect of service quality, product quality, and brand equity on customer value. The analysis uses a structural equation model of 280 respondents chosen using a targeted sampling method, based on a population of BNI (Bank Negara Indonesia) banking clients in the town of Kediri. The results show that e-banking is a moderating factor and makes a positive contribution to the relationship between client value and the company's reputation. Thus, the usage of the online banking network will increase the reputation of the company. The research also proves that service quality and brand equity make a positive contribution to customer value. When the customer's value acts as a power of attorney and makes a positive contribution to the company's reputation.
Table-Top Exercises: дизайн та особливості організації колективних навчань дискусійного типу
Authors: Суходоля О. М.
Published: May 2023

У статті визначаються місце та роль настільної гри (Table-Тop Exercise) у циклі підготовки персоналу сектору безпеки та оборони до впровадження нових управлінських рішень і виявлення недоліків чинного законодавства за умов зміни безпекового середовища. Аналізуються основні проблеми та особливості організації настільних ігор, пропонується методологія визначення мети, цілей проведення навчань, даються практичні рекомендації щодо підбору учасників та порядку проведення навчань і досягнення очікуваних результатів.
Recomendaciones para la aplicación de estrategias bioclimáticas pasivas en un clima mega térmico lluvioso, Tena-Ecuador
Authors: Carrión Atiaja Katia Margarita , Ortega Castro Juan Carlos , Rivela Carballal Beatriz
Published: May 2023

Introducción: el presente estudio tiene como objetivo brindar recomendaciones de diseño bioclimáticas pasivas para la ciudad de Tena, caracterizado por ser un clima mega térmico lluvioso. Metodología: la metodología aplicada se basó en el registro de las variables climáticas (temperatura, radiación solar, humedad relativa, velocidad del viento y precipitación) de la estación meteorológica de la Universidad de Ikiam con datos desde el 2016. Los elementos climáticos fueron analizados en relación con los criterios de confort y herramientas bioclimáticas (Carta bioclimática de Olgyay, Carta Psicométrica y Triángulos de Confort). Resultados: los resultados mostraron la necesidad de utilizar el viento, disminuir la humedad y temperatura al interior de las viviendas durante todos los meses del año. Esto permitió identificar que las principales estrategias bioclimáticas recomendadas para la ciudad de Tena están relacionadas a la orientación y forma de la vivienda, generación de sombra, ventanas e inercia térmica. Estas recomendaciones permitirán a los diseñadores arquitectónicos adoptar estrategias adecuadas de enfriamiento pasivo para mejorar el confort térmico.
Model pembelajaran cooperatif learning tipe STAD dalam pelajaran matematika untuk meningkatan motivasi dan prestasi belajar
Authors: Hayati
Published: May 2023

Penelitian ini bertujuan untuk mengetahui efektifitas model pembelajaran Kooperatif Tipe Student Teams Achievement Divisions (Stad) dalam meningkatkan motivasi dan prestasi belajar matematika di SDN Niten Tahun pelajaran 2017/2018. Jenis penelitian ini adalah penelitian Tindakan Kelas (PTK). Hasil penelitian menunjukkan bahwa peningkatan motivasi belajar peserta didik terhadap mata pelajaran matematika terlihat dari meningkatnya skor, dari 95 % siklus I ke 100% siklus II. Peningkatan prestasi belajar terlihat dari hasil post tes yaitu nilai rata-rata di atas KKM 75, pada siklus I 86,6 dan siklus II 82,45. Ketuntasan pada siklus I 90 % dan pada siklus II 80 %.Proses pembelajaran matematika dengan melalui penerapan model pembelajaran kooperatif learning tipe STAD terbukti dapat meningkatkan motivasi belajar,dan prestasi belajar peserta didik kelas VI SD Negeri Niten tahun Pelajaran 2017/2018.
Công bố thông tin trách nhiệm xã hội doanh nghiệp: Trường hợp các doanh nghiệp ngành sản xuất thực phẩm niêm yết trên Sở giao dịch Chứng khoán Thành phố Hồ Chí Minh
Authors: Châu Thị Lệ Duyên , Phước Minh Hiệp , Lê Tấn Nghiêm , Nguyễn Thanh Liêm , Nguyễn Minh Cảnh , Trịnh Bảo Ngọc
Published: May 2023

Bài báo nghiên cứu những yếu tố ảnh hưởng đến việc công bố thông tin trách nhiệm xã hội trong báo cáo thường niên của các công ty thuộc lĩnh vực sản xuất thực phẩm niêm yết trên Sở giao dịch chứng khoán Thành phố Hồ Chí Minh. Kết quả cho thấy các biến quy mô doanh nghiệp và khả năng sinh lời đều có ảnh hưởng đến mức độ công bố thông tin trách nhiệm xã hội của các doanh nghiệp ngành sản xuất thực phẩm niêm yết, sự biến động của các biến này giải thích được 21,29% sự biến động của biến phụ thuộc. Nghiên cứu cũng chỉ ra rằng không tìm thấy sự ảnh hưởng của đòn bẩy tài chính, quy mô hội đồng quản trị và kiểm toán độc lập đến mức độ công bố thông tin trách nhiệm xã hội của các doanh nghiệp, đồng thời việc công bố thông tin về trách nhiệm xã hội sẽ tạo nên nhiều tác động tích cực đến lợi ích kinh doanh và hiệu quả tài chính, góp phần thúc đẩy mục tiêu phát triển bền vững của doanh nghiệp trong tương lai.
Regiones: La soldado de oro
Authors:   Universidad del Azuay, Alvarez John
Published: May 2023

En este libro se habla de las dificultades y obstáculos que se presentan en el proceso de lograr una meta. Esta historia, a través de uno de mis personajes más queridos, nos enseña que, en ocasiones, para lograr sus objetivos y anhelos, un campeón tiene que aprender a perder. Hace mucho tiempo, los monarcas de cada región se reunieron y decidieron organizar competencias de desafío físico en donde los ganadores portarían diferentes rangos de armaduras: oro para los ganadores, plata para quienes queden en segundo lugar y bronce para los que obtuvieran el tercer lugar. Estas competencias se volvieron parte de las festividades de los pueblos, por lo que cada participante contaba con el apoyo incondicional de su gente. En la época actual existe un buen número de campeones que están bajo las órdenes de Ercos, el monarca de la región Norte y rey de todas las regiones, quien mantiene algunas intenciones ocultas... 268 páginas ISBN: 978-9942-618-18-4 E- ISBN: 978-9942-618-19-1
Manual de protocolo y eventos de la Universidad del Azuay
Authors:   Universidad del Azuay, Calderón-González Priscila
Published: May 2023

El presente Manual de protocolo y eventos de la Universidad del Azuay busca generar una guía para diferentes actividades académicas y sociales que se realizan dentro y fuera de la institución. Este libro permite implementar porceso, planeación y ejecución hacia los diferentes aspectos elementales relacionados al protocolo universitario. El propósito de este manual es brindar a la comunicadad universitaria una herramienta para conocer de mejor manera cómo se manejan los eventos dentro de nuestra institución. 248 páginas ISBN 978-9942-618-70-2 E-ISBN 978-9942-618-71-9
Eeva Kangasmaa-Minn The Syntactical Distribution of the Cheremis Genetive I
Authors: Itkonen Erkki
Published: May 2023

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Aurélien Sauvageot Esquisse de la langue hongroise
Authors: Fazekas Jenö
Published: May 2023

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Application of the Guided Discovery Learning Model to Improve Student Learning Outcomes in Fractions Division Material
Authors: Akina Akina , Mufidah Mufidah , Sani Nurul Kami , Astuti Gusti Ayu Made Nova
Published: May 2023

This study aims to obtain a description of the application of the guided discovery learning model to improve student learning outcomes in the matter of dividing fractions in the VA class of SDN 5 Palu. This type of research is Classroom Action Research (PTK) which refers to the research design of Kemmis and Mc. Taggart, namely (1) planning, (2) implementing actions, (3) observation, and (4) reflection. The subjects in this study were all students of VA class at SDN 5 Palu for the 2022/2023 school year with a total of 24 students consisting of 14 female students and 10 male students. The type of data in this study is qualitative data supplemented by quantitative data. Qualitative data collection techniques in this study were observation, interviews, and field notes. The quantitative data collection technique in this study was a written test. This research was conducted in two cycles. The results of the study show that learning with the guided discovery learning model could increase students’ learning outcomes of VA Class of SDN 5 Palu on the matter of division of fractions. This is evidenced by the increase in student learning outcomes from cycle I to cycle II. The learning outcomes of the first cycle were obtained at 62.5%, and the second cycle was obtained at 83.33%. The results of the analysis of the observation sheet of teacher and student activities in cycle 1 were in the sufficient category. In cycle 2, the teacher and student activity observation sheet increased because the teacher activity observation sheet was in the very good category and the student activity observation sheet was in the good category, so that the success indicators of the action have been achieved.
The Effect of Sorbitol on the Mechanical Properties of Temu Ireng Rhizomes (Curcuma Aeruginosa Roxb.) Starch Biodegradable Plastic
Authors: Manurung Santy Meilisa , Frida Erna , Susilawati Susilawati , Humaidi Syahrul , Sinuhaji Perdinand
Published: May 2023

Biodegradable plastic is made by mixing from temu ireng rhizomes starch matrix, sorbitol as a plasticizer, and chitosan as a filler through the melt intercalation method. heating process at 800C and drying at 70oC. The results show that the addition of chitosan and sorbitol has an effect on the characteristics of the plastic. The best tensile strength results on biodegradable plastic with a mass composition of starch: chitosan 5:5 gram without the addition of sorbitol is 4.03 MPa. The best percentage of elongation in plastic with a composition of starch: chitosan 8:2 gr and 3 ml Sorbitol is 99.68%. The best water resistance to biodegradable plastic was the composition of starch: chitosan 5:5 gr without the addition of sorbitol is 83.33%. And the best biodegradability in plastic with a composition of 5:5 chitosan without the addition of sorbitol  was 100% for 9 days. FTIR test results show that biodegradable plastic have the same wavelength as their constituent raw materials. This shows that the resulting film only interacts physically.
Rainfall Characteristics In Medan City With Pearson Correlation Analysis (Case Study Of February 27, 2022)
Authors: Paramita Endah , Humaidi Syahrul , Darmawan Yahya
Published: May 2023

February is climatologically the first peak of the dry season in the North Sumatra region, but floods can still occur. This study analyzes the characteristics of rainfall patterns that occur during extreme rainfall that occurred in the Medan area on February 27, 2022 which resulted in flooding in several areas in Medan with Pearson correlation. The data used are rainfall data, satellite data, radar and other atmospheric dynamics analysis data. Based on dynamic analysis on February 27, 2022, the growth of CB clouds began at 14.00 WIB reaching its peak at 17.00 WIB where the peak temperature of the cloud reached 82.4 ° C and cloud growth lasted until 21.00 WIB, where the rain lasted long enough to cause hydrometeorological disasters (floods) to occur. The Pearson correlation coefficient method (r) used to analyze the relationship between rainfall and DMI, ENSO, SST Anomalies and SOI conditions can be seen that the dominant influence is SST Anomalies and SOI, where in February conditions that affect rainfall are ENSO with a correlation value of 0.36272 and SST Anomalies with a correlation value of 0.37548.
Fibroepithelial Polyp Arising From the Nasal Septum: A Case Report and a Literature Review
Authors: Jin Woohyen , Lee Chang Hyeon , Lee Tae-Hun , Kim Sang-Wook
Published: May 2023

Fibroepithelial polyp (FEP) is a benign tumor of mesodermal origin, which is mostly found on the skin. FEPs in the upper respiratory system are reported mostly originating from the oropharynx and larynx, and are rarely found in the nasal cavity. A 57-year-old female presented with a polyp-like lesion on the right nasal septal mucosa adjacent to the mucocutaneous junction. The mass was surgically removed, and a diagnosis of FEP was made based on the histopathological review. This is the first report of FEP arising from the nasal septum.
The Mechanisms and Overcoming Strategies of the Radioresistance in Head and Neck Cancer
Authors: Han Myung Woul
Published: May 2023

Radiotherapy plays an important role in the treatment of most of solid tumors including head and neck squamous cell carcinoma (HNSCC). Radioresistance can lead to locoregional recurrence and distant metastases. Despite significant progress in research of radioresistance, its prediction and overcoming strategies remain challenging. This review describes the potential biomarkers correlated to the radioresistance and complex signal pathway in mechanism of radioresistance focusing on the PI3K and EphA3 pathway.
Virtual Surgical Planning for 3 Dimensional Mandibular Reconstruction With Free Fibular Osseous Flaps
Authors: Kim Joo Hyun , Lee Hwa-Seon , Yang Hyun Woo , Choi Eun Chang
Published: May 2023

Fibular vascularized osteocutaneous free flap is the gold standard for mandibular reconstruction. The traditional method is very difficult and challenging work. This technique has so far been performed solely depending on the experience of the surgeons. Recently, several software programs that can make accurate preoperative surgical plans in a three dimensional (3D)-virtual system have been developed and used to solve this problem. The aim of this study is to describe our experience and to share several tips and pitfalls of mandibular reconstruction with virtual surgical planning (VSP).
Показники та критерії оцінювання ефективності функціонування системи управління оборонними ресурсами сектору безпеки та оборони України (структура, зміст)
Authors: Semenenko Oleh , Skurinevska Lesia
Published: May 2023

Мета роботи: визначення структури та змісту показників та критеріїв оцінювання ефективності функціонування системи управління оборонними ресурсами сектору безпеки та оборони України.

Метод дослідження: методи аналізу та синтезу, методи воєнно-економічної теорії, індукції та дедукції, а також порівняння, формалізація, абстрагування та моделювання.

Результати дослідження: визначено структуру і зміст показників та критеріїв оцінювання ефективності функціонування системи управління оборонними ресурсами, а також сформовано вимоги до них та запропоновано підхід до їх класифікації.

Теоретична цінність дослідження: розкриття основних аспектів формування системи показників та критеріїв оцінювання ефективності функціонування системи управління оборонними ресурсами, а також визначено можливі напрями та шляхи подальшого її розвитку.

Тип статті: теоретичний, описовий, практичний, методичний.
A importância da fisioterapia cardiorrespiratória em unidade de terapia intensiva: um estudo de revisão
Authors: Silva Edilane Lima da , Moura Lyara Karyn Pereira de , Monteiro Fábio Teixeira , Silva Geraedson Aristides da , Ferro Thauan Narciso de Lima
Published: May 2023

Introdução: A fisioterapia cardiorrespiratória é atualmente uma intervenção eficaz em pacientes em unidades de terapia intensiva, visando o processo de reabi­litação e restauração do desempenho funcional. Objetivo: pontar quais os benefícios da fisioterapia cardiorrespiratória na reabilitação do paciente em Unidade de Terapia Intensiva, de acordo com as evidências da literatura científica. Metodologia: foi realizado uma revisão integrativa, dos materiais científicos, publicados em revistas indexadas, entre os anos de 2014 a 2022, tendo como referência as bases de dados: Banco de dados de evidências em fisioterapia (PEDro), PubMed, e Scientific Electronic Library Online (SciELO), salientando-se o que tem de mais atual sobre o tema desta discussão. Conclusão: Verificou-se que, a atuação do fisioterapeuta dentro da UTI junto a pacientes com comprometimentos cardiorrespiratórios é fundamental para promover a saúde cardiovascular.
A hibridização como forma de conservação e melhoramento genético da família Arecaceae: uma revisão sobre a palmeira x Butyagrus paranaënsis Engels, T.A.Meyer & K.Soares nothsp. nov
Authors: Duarte Cibele dos Santos , Trevisan Adriana Carla Dias , Pereira Antônio Batista
Published: May 2023

A família Arecaceae, é conhecida pela sua importância econômica e ambiental, com ampla distribuição mundial devido a sua adaptabilidade a condições climáticas e edáficas, é encontrada em todos os biomas brasileiros. Este trabalho consiste em uma revisão narrativa, a partir de publicações científicas sobre a Família e, mais especificamente, dos gêneros Butia (Becc.) Becc. e Syagrus Mart. Os dados foram obtidos a partir de literatura cientifica em livros, sites e revistas digitais. Uma reunião de características botânicas e biogeográficas dos gêneros citados, com o objetivo de fundamentar trabalhos de pesquisa sobre alternativas viáveis à conservação e valorização dessas palmeiras. Tendo como proposta o desenvolvimento de técnicas de melhoramento por hibridação, na obtenção de respostas desejáveis comercialmente e para implementar propostas de preservação das palmeiras nativas. Buscando enfatizar a importância das palmeiras tanto para os ecossistemas, quanto para o desenvolvimento econômico das comunidades afim de buscar alternativas para sua preservação.
Auriculoterapia como prática integrativa e complementar a saúde no cuidado da ansiedade: revisão integrativa
Authors: Rodrigues Patricia Luglime de Oliveira , Espirito Santo Antonia Cristina do , Guimaraes Regiane Cristina Oliveira , Damasceno Charliana Aragão
Published: May 2023

A auriculoterapia é uma terapia natural que utiliza o estímulo de pontos específico do pavilhão auricular, um microssistema do corpo humano, gerando estimulação do córtex cerebral que por reflexo age equilibrando o organismo, proporcionando um bem-estar físico, mental e emocional. O objetivo deste estudo foi realizar uma revisão integrativa sobre as evidências clínicas da auriculoterapia no cuidado da ansiedade como uma prática integrativa e complementar a saúde; sendo utilizadas para o levantamento das literaturas as bases de dados: GOOGLE ACADÊMICO, PUBMED, BVS e SCIELO. Foi realizada uma seleção criteriosa dos artigos científicos através dos critérios de inclusão e exclusão adotados, com seleção de oito artigos do tipo ensaio clínico, sendo 75% (6/8) caracterizados como randomizados e 25% (2/8) definidos como não randomizado. A análise dos estudos permitiu inferir que a prática da auriculoterapia apresenta resultados estatísticos significativos no tratamento complementar da ansiedade, independente do material de pressão auricular usado, baseado nas abordagens metodológicas adotadas. É importante destacar que os ensaios clínicos randomizados averiguados usavam diferentes amostragens com médio a elevado grau de ansiedade, tais como, estudantes, mulheres no pré-parto, profissionais da saúde e do sistema prisional. Adicionalmente, a auriculoterapia possui vantagens como: fácil aplicação, baixo custo, mínimos efeitos colaterais e utilização de materiais não invasivos. Fato este que permite a população ter acesso a essa terapia integrativa e complementar que contribui com a saúde integral do usuário, em especial, do Sistema Único de Saúde.
Morphemic Reduplications in Geguritan
Authors: Susetyaningsih Ririn , Handayani Wiwik Retno
Published: May 2023

The research aims at investigating morphemic reduplication in terms of its kinds and meanings in Javanese poetry, widely known as geguritan. This descriptive qualitative study obtained the data from an anthology of geguritans entitled Cathetan Kanggo Lintang by Irul S. Budianto. An interpretative method was conducted after the data were noted, listed, verified, and classified based on the kinds of meanings of reduplication as proposed by Wijana. The research findings show that the kinds of reduplication found in the geguritans can be classified into four: full reduplication, reduplication with sound modification, partial initial syllabic reduplication, and reduplication combined with affixation. In addition, only nine out of 12 categories of the meanings of reduplication were found in the data. The absence of the three categories is due to the difference between the language style used in geguritan and the language used in daily conversation.
“Jangan Di-Read!”: Indonesian Affixation to English Words on Social Media
Authors: Budiarti Dian , Faris Ihsan Nur Iman
Published: May 2023

Code mixing has been widely studied, but the study of it focusing on Indonesian affixation to English words is still scant. Therefore, this study aims at investigating the types of affixes, the change in English word classes, and the morphophonemic processes that occurred on social media, specifically on Instagram. Simak method was employed to collect 90 Indonesian affixed-English words from 3 Instagram users’ photo captions as the data. Furthermore, Kridalaksana (2007) and Ramlan’s (2001) theories of affixation were employed to analyze the data. The findings demonstrate that the most frequently used affix is a prefix, with di- recorded as the highest number. As for the lexical function formed after the process of affixation, this study reveals three forms, namely (a) verb-forming, (b) adjectival-forming, and (c) noun-forming with verb-forming is the most frequently used. Finally, in terms of its morphophonemic processes, it is more common that the base form of the English words is maintained rather than considering the phonological rules as regulated in the Indonesian language. These preliminary findings suggest that such affixation does not consider EYD V due to the informal setting the social media mostly constructs.
Antibiotics, Efflux, and pH
Authors: Hillman Tatiana
Published: May 2023

Bacterial metabolism affects the effectiveness of antibiotics. Bacterial metabolism is linked to the ability of an antibiotic to be bactericidal or bacteriostatic because a bacterium can metabolize carbohydrates that affect its pH and its ability to use the proton motive force (PMF). When the pH is low, there is more availability of protons that can help to power the proton motive force needed for the efflux of antibiotics. Antibiotics increase the internal pH of a bacterial cell, but when the external pH is low or acidic, the lethality of the antibiotics dwindles. Adding an efflux inhibitor (EI) can block the efflux of antibiotics; however, the pH also affects the effectiveness of the efflux inhibitor. At a low pH the efflux inhibitor cannot block the efflux of antibiotics. This is important for the effectiveness of EIs to block efflux in acidic bacterial environments such as in the stomach or in the small intestines where the pH is highly acidic and low. However, in the colon the pH is highly alkaline and higher leading to a lesser availability of protons, in which the bacterial cells must rely on carbohydrate metabolism to expel any noxious agent such as an antibiotic via the ATP activation of the ABC transporter. As a consequence, for an efflux inhibitor to be effective the pH and the metabolism of carbohydrates to power the ABC transporter must be considered in the design of potential efflux inhibitors. This commentary will offer support for the arguments made in the article, Reducing bacterial antibiotic resistance by targeting bacterial metabolic pathways and disrupting RND efflux pump activity, by presenting the results of experiments that prove the gene inhibition of the AcrAB-TolC subunits of AcrB and TolC as a potent and effective EI design.
Engineering Escherichia coli for diagnosis and management of hyperuricemia
Authors: Gencer Gozde , Mancuso Christopher , Chua Koon Jiew , Ling Hua , Costello Cait M. , Chang Matthew Wook , March John C.
Published: May 2023

Uric acid disequilibrium is implicated in chronic hyperuricemia-related diseases. Long-term monitoring and lowering of serum uric acid levels may be crucial for diagnosis and effective management of these conditions. However, current strategies are not sufficient for accurate diagnosis and successful long-term management of hyperuricemia. Moreover, drug-based therapeutics can cause side effects in patients. The intestinal tract plays an important role in maintaining healthy serum acid levels. Hence, we investigated the engineered human commensal Escherichia coli as a novel method for diagnosis and long-term management of hyperuricemia. To monitor changes in uric acid concentration in the intestinal lumen, we developed a bioreporter using the uric acid responsive synthetic promoter, pucpro, and uric acid binding Bacillus subtilis PucR protein. Results demonstrated that the bioreporter module in commensal E. coli can detect changes in uric acid concentration in a dose-dependent manner. To eliminate the excess uric acid, we designed a uric acid degradation module, which overexpresses an E. coli uric acid transporter and a B. subtilis urate oxidase. Strains engineered with this module degraded all the uric acid (250 µM) found in the environment within 24 h, which is significantly lower (p < 0.001) compared to wild type E. coli. Finally, we designed an in vitro model using human intestinal cell line, Caco-2, which provided a versatile tool to study the uric acid transport and degradation in an environment mimicking the human intestinal tract. Results showed that engineered commensal E. coli reduced (p < 0.01) the apical uric acid concentration by 40.35% compared to wild type E. coli. This study shows that reprogramming E. coli holds promise as a valid alternative synthetic biology therapy to monitor and maintain healthy serum uric acid levels.
Multi-functional nanogel with cascade catalytic performance for treatment of diabetic oral mucosa ulcer
Authors: Zheng Yanfen , Li Zhiguo , Liu Chuyi , Fan Xiaotong , Luo Zheng , Li Zibiao , Wu Yun-Long
Published: May 2023

Introduction: Diabetic oral mucosa ulcers face challenges of hypoxia, hyperglycemia and high oxidative stress, which result in delayed healing process. Oxygen is regarded as an important substance in cell proliferation, differentiation and migration, which is beneficial to ulcer recovery.

Methods: This study developed a multi-functional GOx-CAT nanogel (GCN) system for the treatment of diabetic oral mucosa ulcers. The catalytic activity, ROS scavenge and oxygen supply ability of GCN was validated. The therapeutic effect of GCN was verified in the diabetic gingival ulcer model.

Results: The results showed that the nanoscale GCN was capable of significantly eliminating intracellular ROS, increasing intracellular oxygen concentration and accelerating cell migration of human gingival fibroblasts, which could promote diabetic oral gingival ulcer healing in vivo by alleviating inflammation and promoting angiogenesis.

Discussion: This multifunctional GCN with ROS depletion, continuous oxygen supply and good biocompatibility, which might provide a novel therapeutic strategy for effective treatment of diabetic oral mucosa ulcers.
Faster smooth muscle cell coverage in ultrathin-strut drug-eluting stent leads to earlier re-endothelialization
Authors: Hahn Dongwoo , Lee Donghoon , Hyun Woonggyu , Cho Yunnie , Yoon Chang-Hwan , Jeon Ki-Hyun , Kang Si-Hyuck , Youn Tae-Jin , Chae In-Ho
Published: May 2023

Background: The ultrathin-strut drug-eluting stent (DES) has shown better clinical results than thin- or thick-strut DES. We investigated if re-endothelialization was different among three types of DES: ultrathin-strut abluminal polymer-coated sirolimus-eluting stent (SES), thin-strut circumferential polymer-coated everolimus-eluting stent (EES), and thick-strut polymer-free biolimus-eluting stent (BES) to gain insight into the effect of stent design on promoting vascular healing.

Methods: After implanting three types of DES in the coronary arteries of minipigs, we performed optical coherence tomography (OCT) at weeks 2, 4, and 12 (n = 4, each). Afterward, we harvested the coronary arteries and performed immunofluorescence for endothelial cells (ECs), smooth muscle cells (SMCs), and nuclei. We obtained 3D stack images of the vessel wall and reconstructed the en face view of the inner lumen. We compared re-endothelialization and associated factors among the different types of stents at different time points.

Results: SES showed significantly faster and denser re-endothelialization than EES and BES at weeks 2 and 12. Especially in week 2, SES elicited the fastest SMC coverage and greater neointimal cross-sectional area (CSA) compared to EES and BES. A strong correlation between re-endothelialization and SMC coverage was observed in week 2. However, the three stents did not show any difference at weeks 4 and 12 in SMC coverage and neointimal CSA. At weeks 2 and 4, SMC layer morphology showed a significant difference between stents. A sparse SMC layer was associated with denser re-endothelialization and was significantly higher in SES. Unlike the sparse SMC layer, the dense SMC layer did not promote re-endothelialization during the study period.

Conclusion: Re-endothelialization after stent implantation was related to SMC coverage and SMC layer differentiation, which were faster in SES. Further investigation is needed to characterize the differences among the SMCs and explore methods for increasing the sparse SMC layer in order to improve stent design and enhance safety and efficacy.
Multi-functional approach in the design of smart surfaces to mitigate bacterial infections: a review
Authors: Rajaramon Shobana , David Helma , Sajeevan Anusree , Shanmugam Karthi , Sriramulu Hrithiha , Dandela Rambabu , Solomon Adline Princy
Published: May 2023

Advancements in biomedical devices are ingenious and indispensable in health care to save millions of lives. However, microbial contamination paves the way for biofilm colonisation on medical devices leading to device-associated infections with high morbidity and mortality. The biofilms elude antibiotics facilitating antimicrobial resistance (AMR) and the persistence of infections. This review explores nature-inspired concepts and multi-functional approaches for tuning in next-generation devices with antibacterial surfaces to mitigate resistant bacterial infections. Direct implementation of natural inspirations, like nanostructures on insect wings, shark skin, and lotus leaves, has proved promising in developing antibacterial, antiadhesive, and self-cleaning surfaces, including impressive SLIPS with broad-spectrum antibacterial properties. Effective antimicrobial touch surfaces, photocatalytic coatings on medical devices, and conventional self-polishing coatings are also reviewed to develop multi-functional antibacterial surfaces to mitigate healthcare-associated infections (HAIs).
Efficacy of adjuvant metronidazole therapy on peri-implantitis: a systematic review and meta-analysis of randomized clinical studies
Authors: López-Valverde Nansi , López-Valverde Antonio , Blanco-Rueda José Antonio
Published: May 2023

Peri-implant diseases are pathological conditions that affect the survival of dental implants. Etiological studies are limited, accepting a prevalence of 20% at the implant level and 24% at the patient level. The benefits of adjuvant metronidazole are controversial. A systematic review and meta-analysis of RCTs according to PRISMA and PICOS was performed with an electronic search over the last 10 years in MEDLINE (PubMed), WOS, Embase, and Cochrane Library. The risk of bias was measured using the Cochrane Risk of Bias tool and the methodological quality using the Jadad scale. Meta-analysis was performed with RevMan version 5.4.1, based on mean difference and standard deviation, with 95% confidence intervals; the random-effects model was selected, and the threshold for statistical significance was defined as p < 0.05. A total of 38 studies were collected and five were selected. Finally, one of the studies was eliminated because of unanalyzable results. All studies reached a high methodological quality. A total of 289 patients were studied with follow-up periods from 2 weeks to 1 year. Statistical significance was only found, with respect to the use of adjunctive metronidazole, in the pooled analysis of the studies (p = 0.02) and in the analysis of the radiographic values reported on peri-implant marginal bone levels, in the studies with a 3-month follow-up (p = 0.03). Discrepancies in the use of systemic metronidazole require long-term randomized clinical trials (RCTs) to determine the role of antibiotics in the treatment of peri-implantitis.
Correlation between serum GDF-15 level and pulmonary vascular morphological changes and prognosis in patients with pulmonary arterial hypertension
Authors: Maimaiti Yasenjiang , Cheng Hui , Guo Zitong , Yu Xiaolin , Tuohuti Adilijiang , Li Guoqing
Published: May 2023

Objective

To investigate how serum GDF-15 concentration affects pulmonary artery hemodynamics and pulmonary vascular morphological changes in patients with pulmonary arterial hypertension.

Methods

A total of 45 patients admitted to our hospital from December 2017 to December 2019, were selected for the study. Pulmonary vascular hemodynamics and pulmonary vascular morphology were detected by RHC and IVUS. Serum GDF-15 levels were detected by enzyme-linked immunosorbent assay (ELISA). Based on the concentration of GDF-15, the patients were divided into two groups—the normal GDF-15 group (GDF-15 <1,200 pg/ml, 12 cases) and the elevated GDF-15 group (GDF-15 ≥1,200 pg/ml, 33 cases). A statistical analysis was performed to compare the effects of normal blood GDF-15 levels and high serum GDF-15 levels on hemodynamics and pulmonary vascular morphology in each group of patients.

Results

The average levels of RVP, sPAP, dPAP, mPAP, and PVR in patients with elevated GDF-15 levels were higher than those in patients with normal GDF-15 levels. The difference between the two groups was statistically significant (P < 0.05). The average levels of Vd, elastic modulus, stiffness index β, lesion length, and PAV in the normal GDF-15 group were lower than those in the elevated GDF-15 group. The average levels of compliance, distensibility, and minimum l umen area were higher than those in the elevated GDF-15 group. The difference between the two groups was statistically significant (P < 0.05). The survival analysis results showed that the 1-year survival rate of patients with normal GDF-15 levels and elevated GDF-15 levels was 100% and 87.9%, respectively, and that the 3-year survival rate of patients with normal GDF-15 levels and elevated GDF-15 levels was 91.7% and 78.8%, respectively. The survival rates of the two groups were compared by the Kaplan Meier method, and the difference was not statistically significant (P > 0.05).

Conclusion

Patients with pulmonary arterial hypertension with elevated GDF-15 levels have higher pulmonary arterial pressure, higher pulmonary vascular resistance, and more serious pulmonary vascular lesions, which are potentially more harmful. There was no statistically significant difference in survival rates among patients with different serum GDF-15 levels.
Effects of inspiratory muscle training in patients with hypertension: a meta-analysis
Authors: Zheng ShuQi , Zhang Qi , Li ShuiYan , Li Shilin , Yao Qiuru , Zheng Xiaoyan , Li Gege , Zeng Yuting , Chen Ling , Chen Shuping , He Longlong , Zou Jihua , Zeng Qing
Published: May 2023

Objective

To explore the effects of inspiratory muscle training (IMT) on hypertension and provide guidance for its clinical application as an auxiliary approach.

Methods

Articles published prior to July 2022 were searched in Cochrane Library, Web of Science, PubMed, Embase, CNKI, and Wanfang databases. Included were randomized controlled studies that used IMT to treat individuals with hypertension. The mean difference (MD) was computed using the Revman 5.4 software. In individuals with hypertension, the effects of IMT on systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), and pulse pressure (PP) were compared and studied.

Results

There were found to be eight randomized controlled trials totaling 215 patients. According to a meta-analysis, the IMT reduced the SBP (MD: −12.55 mmHg, 95% CI: −15.78, −9.33), DBP (MD: −4.77 mmHg, 95% CI: −6.00, −3.54), HR (MD: −5.92 bpm, 95% CI: −8.72, −3.12), and PP (MD: −8.92 mmHg, 95% CI: −12.08, −5.76) in patients with hypertension. In subgroup analyses, low-intensity IMT showed a better reduction in SBP (MD: −14.47 mmHg, 95% CI: −17.60, −11.34), DBP (MD: −7.70 mmHg, 95% CI: −10.21, −5.18).

Conclusion

IMT may become an auxiliary means to improve the four hemodynamic indexes (SBP, DBP, HR and PP) in patients with hypertension. In subgroup analyses, low-intensity IMT was more effective in regulating blood pressure than medium-high-intensity IMT.

Systematic Review Registration

https://www.crd.york.ac.uk/prospero/, identifier: CRD42022300908.
Single coronary artery presenting dilated cardiomyopathy and hyperlipidemia with the SCN5A and APOA5 gene mutation: A case report and review of the literature
Authors: Hu Xiaoxia , Kong Jing , Niu Tingting , Chen Liang , Yang Jingjing
Published: May 2023

We present a 55-year-old man with chest tightness and dyspnoea after activity lasting for 2 months who was diagnosed with single coronary artery (SCA) and presented with dilated cardiomyopathy (DCM) with the c.1858C > T mutation in the SCN5A gene. The computed tomography coronary angiogram (CTCA) showed congenital absence of the right coronary artery (RCA), and the right heart was nourished by the left coronary artery branch with no apparent stenosis. Transthoracic echocardiography (TTE) revealed enlargement of the left heart and cardiomyopathy. Cardiac magnetic resonance imaging (CMR) revealed DCM. Genetic testing showed that the c.1858C > T variant of the SCN5A gene could lead to Brugada syndrome and DCM. SCA is a rare congenital anomaly of the coronary anatomy, and this case reported as SCA accompanied by DCM is even rarer. We present a rare case of a 55-year-old man with DCM with the c.1858C > T (p. Arg620Cys)/c.1008G > A (p.(Pro336=) variant of the SCN5A gene, congenital absence of RCA, and c.990_993delAACA (p. Asp332Valfs*5) variant of the APOA5 gene. To our knowledge, this is the first report of DCM combined with the SCN5A gene mutation in SCA after searching the PubMed, CNKI and Wanfang databases.
Single-cell RNA sequencing provides novel insights to pathologic pathways in abdominal aortic aneurysm
Authors: Bontekoe Jack , Liu Bo
Published: May 2023

There is gaining popularity in the use of single-cell technology and analysis in studying the pathogenesis of abdominal aortic aneurysm (AAA). As there are no current pharmacologic therapies for impeding aneurysm growth or preventing AAA rupture, identifying key pathways involved in AAA formation is critical for the development of future therapies. Single-cell RNA sequencing (scRNA-seq) technology provides an unbiased and global view of transcriptomic characteristics within each of the major cell types in aneurysmal tissues. In this brief review, we examine the current literature utilizing scRNA-seq for the analysis of AAA and discuss trends and future utility of this technology.
Advanced imaging of fetal cardiac function
Authors: Kühle Henriette , Cho Steven K. S. , Barber Nathaniel , Goolaub Datta Singh , Darby Jack R. T. , Morrison Janna L. , Haller Christoph , Sun Liqun , Seed Mike
Published: May 2023

Over recent decades, a variety of advanced imaging techniques for assessing cardiovascular physiology and cardiac function in adults and children have been applied in the fetus. In many cases, technical development has been required to allow feasibility in the fetus, while an appreciation of the unique physiology of the fetal circulation is required for proper interpretation of the findings. This review will focus on recent advances in fetal echocardiography and cardiovascular magnetic resonance (CMR), providing examples of their application in research and clinical settings. We will also consider future directions for these technologies, including their ongoing technical development and potential clinical value.
Identification of transport systems involved in eflornithine delivery across the blood-brain barrier
Authors: Watson Christopher P. , Sekhar Gayathri Nair , Thomas Sarah A.
Published: May 2023

Human African Trypanosomiasis (HAT) is a neglected parasitic disease that continues to persist in sub-Saharan Africa. It is fatal if untreated. The first stage of the disease is associated with the presence of the parasite in the periphery and the second stage with the presence of the parasites in the CNS. The treatment of CNS stage HAT requires the drugs to cross the blood-brain barrier (BBB). Eflornithine is an amino acid analogue that is used to treat second stage HAT gambiense both alone and in combination with nifurtimox. Recent studies have identified that accumulation of eflornithine into the parasites (trypanosomes) involves the amino acid transporter (Trypanosoma brucei AAT6). In this study we tested the hypothesis that eflornithine uses a cationic amino acid transport system to cross the BBB. We particularly focused on system y+ and system B0,+. To do this we utilized specialist databases to compare the physicochemical characteristics of relevant molecules and an in vitro model of the BBB to explore the mechanisms of eflornithine delivery into the CNS. Our results confirmed that eflornithine is related to the endogenous amino acid, ornithine. At pH 7.4, eflornithine is predominately (92.39%) a zwitterionic (dipolar) amino acid and ornithine is predominately (99.08%) a cationic (tripolar) amino acid. In addition, the gross charge distribution at pH 7.4 of eflornithine is much smaller (+0.073) than that of ornithine (+0.99). Further results indicated that eflornithine utilized a saturable transport mechanism(s) to cross the hCMEC/D3 cell membranes and that transport was inhibited by the presence of other amino acids including ornithine. Eflornithine transport was also sodium-independent and sensitive to a y+ system inhibitor, but not a B0,+ system inhibitor. Eflornithine transport was also inhibited by pentamidine, suggestive of transport by organic cation transporters (OCT) which are expressed in this cell line. We confirmed expression of the y+ system protein, CAT1, and the B0,+ system protein, ATB0,+, in the hCMEC/D3 cells. We conclude that eflornithine uses the cationic amino acid transporter, system y+, and OCT to cross the BBB. This research highlights the potential of system y+ to deliver drugs, including eflornithine, across the BBB to treat brain diseases.
The effects of intraseasonal oscillations on landfalling tropical cyclones in the Philippines during the boreal summer
Authors: Wu Peicong , Ling Zheng , He Hailun
Published: May 2023

As a kind of weather phenomenon with destructive wind and heavy rainfall, tropical cyclones (TCs), especially the landing TCs, can cause severer economic damage and losses of life. Philippines is one of the countries mostly affected by Tropical cyclones (TCs). Based on the best-track TC data and global atmospheric and oceanic reanalysis data, the present paper investigates the isolated and combined effects of two intraseasonal oscillations, the Madden-Julian oscillation (MJO) and the quasi-biweekly oscillation (QBWO), on landfall of TCs in the Philippines during boreal summer (May-September) in 1979-2019. The results show that both the MJO and the QBWO can significantly affect the frequency, landfall intensity, location, and translation speed of TCs that make landfall in the Philippines. During the convective (non-convective) phases of the MJO and the QBWO, more (less) frequent and stronger (weaker) TCs make landfall in the Philippines. This is due to the increased (decreased) frequency of TCs formation in the NWP and environmental factors in the region east of the Philippines that are favorable (unfavorable) for the development of TCs. With the northward propagation of the convective signals of the MJO and QBWO, the Western Pacific Subtropical High (WPSH) shifts eastward, and the steering flow is unfavorable for westward movement of NWP TCs. This, in turn, causes a northward shift in the landfall locations and a decrease in the translation speed of TCs. These results are helpful for the prediction of the TCs affecting the Philippines.
Acute stress response of the HPA-axis in children with Prader-Willi syndrome: new insights and consequences for clinical practice
Authors: Grootjen Lionne N. , Kerkhof Gerthe F. , Juriaans Alicia F. , Trueba-Timmermans Demi J. , Hokken-Koelega Anita C. S.
Published: May 2023

Background

Prader-Willi syndrome (PWS) is associated with hypothalamic dysfunction. It has been reported that the HPA axis might show a delayed response during acute stress, and it is unknown whether the response of the HPA-axis during acute stress changes with age in children with PWS.

Aim

To investigate the HPA-axis response during an overnight single-dose metyrapone (MTP) test in children with PWS and to assess if the response changes with age, whether it is delayed and if it changes with repeated testing over time. In addition, we evaluated different cut-off points of ACTH and 11-DOC levels to assess stress-related central adrenal insufficiency (CAI).

Methods

An overnight single-dose MTP test was performed in 93 children with PWS. Over time, 30 children had a second test and 11 children a third one. Children were divided into age groups (0-2 years, 2-4 years, 4-8 years and > 8 years).

Results

Most children did not have their lowest cortisol level at 7.30h, but at 04.00h. Their ACTH and 11-DOC peaks appeared several hours later, suggesting a delayed response. When evaluated according to a subnormal ACTH peak (13-33 pmol/L) more children had an subnormal response compared to evaluation based on a subnormal 11-doc peak (< 200 nmol/L). The percentage of children with a subnormal ACTH response ranged from 22.2 to 70.0% between the age groups, while the percentage of a subnormal 11-DOC response ranged from 7.7 to 20.6%. When using the ACTH peak for diagnosing acute-stress-related CAI, differences between age groups and with repeated testing over time were found, whereas there was no age difference when using the 11-DOC peak.

Conclusion

Early morning ACTH or 11-DOC levels are not appropriate to determine acute stress-related CAI in children with PWS, thus multiple measurements throughout the night are needed for an accurate interpretation. Our data suggest a delayed response of the HPA-axis during acute stress. Using the 11-DOC peak for the test interpretation is less age-dependent than the ACTH peak. Repeated testing of the HPA-axis over time is not required, unless clinically indicated.