bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimisation of Mechanical Properties of Gradient Zr–C Coatings
Authors: Szparaga Łukasz , Bartosik Przemysław , Gilewicz Adam , Mydłowska Katarzyna , Ratajski Jerzy
Published: January 2021

One of the key components of the designing procedure of a structure of hard anti-wear coatings deposited via Physical Vapour Deposition (PVD) is the analysis of the stress and strain distributions in the substrate/coating systems, initiated during the deposition process and by external mechanical loads. Knowledge of residual stress development is crucial due to their significant influence on the mechanical and tribological properties of such layer systems. The main goal of the work is to find the optimal functionally graded material (FGM) coating’s structure, composed of three functional layers: (1) adhesive layer, providing high adhesion of the coating to the substrate, (2) gradient load support and crack deflection layer, improving hardness and enhancing fracture toughness, (3) wear-resistant top layer, reducing wear. In the optimisation procedure of the coating’s structure, seven decision criteria basing on the state of residual stresses and strains in the substrate/coating system were proposed. Using finite element simulations and postulated criteria, the thickness and composition gradients of the transition layer in FGM coating were determined. In order to verify the proposed optimisation procedure, Zr-C coatings with different spatial distribution of carbon concentration were produced by the Reactive Magnetron Sputtering PVD (RMS PVD) method and their anti-wear properties were assessed by scratch test and ball-on-disc tribological test.
Investigating the Size-Dependent Binding of Pristine nC60 to Bovine Serum Albumin by Multi-Spectroscopic Techniques
Authors: Liu Shufang , Wang Shu’e , Liu Zhanzuo
Published: January 2021

The morphology of nanomaterials may affect their interaction with biomacromolecules such as proteins. Previous work has studied the size-dependent binding of pristine nC60 to bovine/human serum albumin using the fluorometric method and found that the fluorescence inner filter effect might affect this interaction. However, if it is necessary to accurately calculate and obtain binding information, the fluorescence inner filter effect should not be ignored. This work aimed to further investigate the effect of the fluorescence inner filter on the interaction between pristine nC60 with different particle sizes (140–160, 120–140, 90–110, 50–70, and 30–50 nm) and bovine serum albumin for a more accurate comprehension of the binding of pristine nC60 to bovine serum albumin. The nC60 nanoparticles with different size distributions used in the experiments were obtained by the solvent displacement and centrifugation method. UV-Vis spectroscopy and fluorescence spectroscopy were used to study the binding of nC60 with different size distributions to bovine serum albumin (BSA) before and after eliminating the fluorescence inner filter effect. The results showed that the fluorescence inner filter effect had an influence on the interaction between nC60 and proteins to some extent, and still did not change the rule of the size-dependent binding of nC60 nanoparticles to BSA. Further studies on the binding parameters (binding constants and the number of binding sites) between them were performed, and the effect of the binding on BSA structures and conformation were also speculated.
Improving Photocatalytic Performance Using Nanopillars and Micropillars
Authors: Waite Jessica , Hunt Julianna , Ji Haifeng
Published: January 2021

A recent research emphasis has been placed on the development of highly crystallized nanostructures as a useful technology for many photocatalytic applications. With the unique construction of semiconductor transition metal oxide nanostructures in the form of nanopillars—artificially designed pillar-shaped structures grouped together in lattice-type arrays—the surface area for photocatalytic potential is increased and further enhanced through the introduction of dopants. This short review summarizes the work on improving the efficiency of photocatalyst nanopillars through increased surface area and doping within the applications of water splitting, removal of organic pollutants from the environment, photoswitching, soot oxidation, and photothermalization.
Effect of High Calcium Fly Ash, Ladle Furnace Slag, and Limestone Filler on Packing Density, Consistency, and Strength of Cement Pastes
Authors: Anastasiou Eleftherios K.
Published: January 2021

Environmental considerations and technical benefits have directed research towards reducing cement clinker content in concrete, and one of the best ways to do this is to replace cement with supplementary cementitious materials. High calcium fly ash, ladle furnace slag, and limestone filler were investigated as supplementary cementitious materials in cement pastes, and binary mixtures were produced at 10%, 20%, and 30% cement replacement rates for each material. The water requirement for maximum packing and for normal consistency were obtained for each paste, and strength development was determined at 3, 7, 28, and 90 days for the 20% replacement rate. Furthermore, two ternary mixtures at 30% cement replacement were also prepared for maximum packing density and tested for compressive strength development. The results showed that high calcium fly ash decreased cement paste packing and increased water demand but contributed to strength development through reactivity. Ladle furnace slag and limestone filler, on the other hand, were less reactive and seemed to contribute to strength development through the filler effect. The ternary paste with 70% cement, 20% high calcium fly ash, and 10% limestone filler showed equivalent strength development to that of the reference cement paste.
A Comprehensive Study on Processing Ti–6Al–4V ELI with High Power EDM
Authors: Karmiris-Obratański Panagiotis , Papazoglou Emmanouil L. , Leszczyńska-Madej Beata , Zagórski Krzysztof , Markopoulos Angelos P.
Published: January 2021

Electrical Discharge Machining (EDM) consists of a non-conventional machining process, which is widely used in modern industry, and especially in machining hard-to-cut materials. By employing EDM, complex shapes and geometries can be produced, with high dimensional accuracy. Titanium alloys, due to their unique inherent properties, are extensively utilized in high end applications. Nevertheless, they suffer from poor machinability, and thus, EDM is commonly employed for their machining. The current study presents an experimental investigation regarding the process of Ti–6Al–4V ELI with high power EDM, using a graphite electrode. Control parameters were the pulse-on current (Ip) and time (Ton), while Machining performances were estimated in terms of Material Removal Rate (MRR), Tool Material Removal Rate (TMRR), and Tool Wear Ratio (TWR). The machined Surface Roughness was calculated according to the Ra and the Rt values, by following the ISO 25178-2 standards. Furthermore, the EDMed surfaces were observed under optical and SEM microscopy, while their cross sections were also studied in order the Average White Layer Thickness (AWLT) and the Heat Affected Zone (HAZ) to be measured. Finally, for the aforementioned indexes, Analysis Of Variance was performed, whilst for the MRR and TMRR, based on the Response Surface Method (RSM), semi-empirical correlations were presented. The scope of the current paper is, through a series of experiments and by employing statistical tools, to present how two main machining parameters, i.e., pulse-on current and time, affect major machining performance indexes and the surface roughness.
Electrically Conductive Micropatterned Polyaniline-Poly(ethylene glycol) Composite Hydrogel
Authors: Noh Soyoung , Gong Hye Yeon , Lee Hyun Jong , Koh Won-Gun
Published: January 2021

Hydrogel substrate-based micropatterns can be adjusted using the pattern shape and size, affecting cell behaviors such as proliferation and differentiation under various cellular environment parameters. An electrically conductive hydrogel pattern system mimics the native muscle tissue environment. In this study, we incorporated polyaniline (PANi) in a poly(ethylene glycol) (PEG) hydrogel matrix through UV-induced photolithography with photomasks, and electrically conductive hydrogel micropatterns were generated within a few seconds. The electrical conductance of the PANi/PEG hydrogel was 30.5 ± 0.5 mS/cm. C2C12 myoblasts were cultured on the resulting substrate, and the cells adhered selectively to the PANi/PEG hydrogel regions. Myogenic differentiation of the C2C12 cells was induced, and the alignment of myotubes was consistent with the arrangement of the line pattern. The expression of myosin heavy chain on the line pattern showed potential as a substrate for myogenic cell functionalization.
Design of a Unique Device for Residual Stresses Quantification by the Drilling Method Combining the PhotoStress and Digital Image Correlation
Authors: Pástor Miroslav , Hagara Martin , Virgala Ivan , Kal’avský Adam , Sapietová Alžbeta , Hagarová Lenka
Published: January 2021

This paper presents a uniquely designed device combining the hole-drilling technique with two optical systems based on the PhotoStress and digital image correlation (DIC) method, where the digital image correlation system moves with the cutting tool. The authors aimed to verify whether the accuracy of the drilled hole according to ASTM E837-13a standard and the positioning accuracy of the device were sufficient to achieve accurate results. The experimental testing was performed on a thin specimen made from strain sensitive coating PS-1D, which allowed comparison of the results obtained by both methods. Although application of the PhotoStress method allows analysis of the strains at the edge of the cut hole, it requires a lot of experimenter’s practical skills to assess the results correctly. On the other hand, the DIC method allows digital processing of the measured data. However, the problem is not only to determine the data at the edge of the hole, the results also significantly depend on the smoothing levels used. The quantitative comparison of the results obtained was performed using finite element analysis.
Transparent Glasses and Glass-Ceramics in the Ternary System TeO2-Nb2O5-PbF2
Authors: Santos Barbosa Juliana , Batista Gislene , Danto Sylvain , Fargin Evelyne , Cardinal Thierry , Poirier Gael , Castro Cassanjes Fabia
Published: January 2021

Transparent fluorotellurite glasses were prepared by melt-quenching in the ternary system TeO2-Nb2O5-PbF2. The synthesis conditions were adjusted to minimize fluorine loss monitored as HF release. It was found that 10 mol% of Nb2O5 is the optimum content for PbF2 incorporation up to 35 mol% in the tellurite matrix without loss of glass forming ability. Such glass compositions exhibit a wide optical window from 380 nm to about 6 μm. Crystallization properties were carefully investigated by thermal analysis and compositions with higher PbF2 contents exhibit preferential precipitation of lead oxyfluoride Pb2OF2 at lower temperatures. The lead oxyfluoride crystallization mechanism is also governed by a volume nucleation, barely reported in tellurite glasses. Eu3+ doping of these glass compositions also promotes a more efficient nucleation step under suitable heat-treatments, resulting in transparent Eu3+-doped glass-ceramics whereas undoped glass-ceramics are translucent. Finally, Eu3+ spectroscopy pointed out a progressive, more symmetric surrounding around the rare earth ions with increasing PbF2 contents as well as higher quantum efficiencies. These new fluorotellurite glass compositions are promising as luminescent hosts working in the middle infrared.
Investigation of the Residual Stress in a Multi-Pass T-Welded Joint Using Low Transformation Temperature Welding Wire
Authors: Feng Zhongyuan , Ma Ninshu , Tsutsumi Seiichiro , Lu Fenggui
Published: January 2021

We investigated whether low transformation temperature (LTT) welding materials are beneficial to the generation of compressive residual stress around a weld zone, thus enhancing the fatigue performance of the welded joint. An experimental and numerical study were conducted in order to analyze the residual stress in multi-pass T-welded joints using LTT welding wire. It was found that, compared to the conventional welded joint, greater tensile residual stress was induced in the flange plate of the LTT welded joints. This was attributed to the reheat temperature of the LTT weld pass during the multi-pass welding. The formerly-formed LTT weld pass with a reheat temperature lower than the austenite finish temperature converted the compressive residual stress into tensile stress. The compressive residual stress was generated in the regions with a reheat temperature higher than the austenite finish temperature, indicating that LTT welding materials are more suitable for single-pass welding.
Apparent Young’s Modulus of the Adhesive in Numerical Modeling of Adhesive Joints
Authors: Anasiewicz Kamil , Kuczmaszewski Józef
Published: January 2021

This article is an evaluation of the phenomena occurring in adhesive joints during curing and their consequences. Considering changes in the values of Young’s modulus distributed along the joint thickness, and potential changes in adhesive strength in the cured state, the use of a numerical model may make it possible to improve finite element simulation effects and bring their results closer to experimental data. The results of a tensile test of a double overlap adhesive joint sample, performed using an extensometer, are presented. This test allowed for the precise determination of the shear modulus G of the cured adhesive under experimental conditions. Then, on the basis of the research carried out so far, a numerical model was built, taking the differences observed in the properties of the joint material into account. The stress distribution in a three-zone adhesive joint was analyzed in comparison to the standard numerical model in which the adhesive in the joint was treated as isotropic. It is proposed that a joint model with three-zones, differing in the Young’s modulus values, is more accurate for mapping the experimental results.
Influence of Long-Term Storage on the Caking Properties Determined in Punch Test and Fungal Contamination of Potato Starch and Wheat Flour
Authors: Wajs Justyna , Panek Jacek , Frąc Magdalena , Stasiak Mateusz
Published: January 2021

The presented results are an attempt to identify the changes taking place during a punch test experiment and the development of fungal impurities of powdered food materials over long-term storage at 75% RH. The potato starch and wheat flour market has a large share of the global production of bulk materials. The growing interest in powdered food materials requires additional production expenditure. This is associated with an increase in storage time of the discussed product and providing it with the appropriate conditions. The samples of potato starch and wheat flour were stored in perforated containers in a climatic chamber at 75% humidity and 21 °C for five months and then samples were measured by a punch test in a Lloyd LRX materials testing machine. The graphs obtained in the potato starch punch test differed significantly from wheat flour. The thickening of potato starch was observed in the form of layers, while potato starch was uniformly thickened throughout the experiment. The conditions of 75% humidity and 21 °C can be described as the beginning of the caking process. In potato starch, linear sections were observed, which changed the length of their storage time and, additionally, was correlated with the appearance of fungal contamination. These results may suggest the influence of fungi on the phenomenon of bulk material caking.
Palm Oil Fuel Ash-Based Eco-Efficient Concrete: A Critical Review of the Short-Term Properties
Authors: Amran Mugahed , Murali Gunasekaran , Fediuk Roman , Vatin Nikolai , Vasilev Yuriy , Abdelgader Hakim
Published: January 2021

The huge demand for concrete is predicted to upsurge due to rapid construction developments. Environmental worries regarding the large amounts of carbon dioxide emanations from cement production have resulted in new ideas to develop supplemental cementing materials, aiming to decrease the cement volume required for making concrete. Palm-oil-fuel-ash (POFA) is an industrial byproduct derived from palm oil waste’s incineration in power plants’ electricity generation. POFA has high pozzolanic characteristics. It is highly reactive and exhibits satisfactory micro-filling ability and unique properties. POFA is commonly used as a partially-alternated binder to Portland cement materials to make POFA-based eco-efficient concrete to build building using a green material. This paper presents a review of the material source, chemical composition, clean production and short-term properties of POFA. A review of related literature provides comprehensive insights into the potential application of POFA-based eco-efficient concrete in the construction industry today.
Fabrication of (SiC-AlN)/ZrB2 Composite with Nano-Micron Hybrid Microstructure via PCS-Derived Ceramics Route
Authors: Xia Aidong , Yin Jie , Chen Xiao , Huang Zhengren , Liu Xuejian , Liu Wei
Published: January 2021

In this work, a (SiC-AlN)/ZrB2 composite with outstanding mechanical properties was prepared by using polymer-derived ceramics (PDCs) and hot-pressing technique. Flexural strength reached up to 460 ± 41 MPa, while AlN and ZrB2 contents were 10 wt%, and 15 wt%, respectively, under a hot-pressing temperature of 2000 °C. XRD pattern-evidenced SiC generated by pyrolysis of polycarbosilane (PCS) was mainly composed by 2H-SiC and 4H-SiC, both belonging to α-SiC. Micron-level ZrB2 secondary phase was observed inside the (SiC-AlN)/ZrB2 composite, while the mean grain size (MGS) of SiC-AlN matrix was approximately 97 nm. This unique nano-micron hybrid microstructure enhanced the mechanical properties. The present investigation provided a feasible tactic for strengthening ceramics from PDCs raw materials.
A Low-Viscosity BisGMA Derivative for Resin Composites: Synthesis, Characterization, and Evaluation of Its Rheological Properties
Authors: Alrahlah Ali , Al-Odayni Abdel-Basit , Al-Mutairi Haifa Fahad , Almousa Bashaer Mousa , Alsubaie Faisal S. , Khan Rawaiz , Saeed Waseem Sharaf
Published: January 2021

This study aimed to synthesize new bisphenol A-glycidyl methacrylate (BisGMA) derivatives, targeting a reduction in its viscosity by substituting one of its OH groups, the leading cause of its high viscosity, with a chlorine atom. Hence, this monochloro-BisGMA (mCl-BisGMA) monomer was synthesized by Appel reaction procedure, and its structure was confirmed using Fourier transform infrared spectroscopy, 1H and 13C-nuclear magnetic resonance spectroscopy, and mass spectroscopy. The viscosity of mCl-BisGMA (8.3 Pa·s) was measured under rheometry conditions, and it was found to be more than 65-fold lower than that of BisGMA (566.1 Pa·s) at 25 °C. For the assessment of the viscosity changes of model resins in the presence of mCl-BisGMA, a series of resin matrices, in which, besides BisGMA, 50 wt % was triethylene glycol dimethacrylate, were prepared and evaluated at 20, 25, and 35 °C. Thus, BisGMA was incrementally replaced by 25% mCl-BisGMA to obtain TBC0, TBC25, TBC50, TBC75, and TBC100 blends. The viscosity decreased with temperature, and the mCl-BisGMA content in the resin mixture increased. The substantial reduction in the viscosity value of mCl-BisGMA compared with that of BisGMA may imply its potential use as a dental resin matrix, either alone or in combination with traditional monomers. However, the various properties of mCl-BisGMA-containing matrices should be evaluated.
Pricing of Commodity and Energy Derivatives for Polynomial Processes
Authors: Benth Fred Espen
Published: January 2021

Operating in energy and commodity markets require a management of risk using derivative products such as forward and futures, as well as options on these. Many of the popular stochastic models for spot dynamics and weather variables developed from empirical studies in commodity and energy markets belong to the class of polynomial jump diffusion processes. We derive a tailor-made framework for efficient polynomial approximation of the main derivatives encountered in commodity and energy markets, encompassing a wide range of arithmetic and geometric models. Our analysis accounts for seasonality effects, delivery periods of forwards and exotic temperature forwards where the underlying “spot” is a nonlinear function of the temperature. We also include in our derivations risk management products such as spread, Asian and quanto options.
Microscopically Reversible Pathways with Memory
Authors: Arias-Gonzalez Jose Ricardo
Published: January 2021

Statistical mechanics is a physics theory that deals with ensembles of microstates of a system compatible with environmental constraints and that on average define a thermodynamic state. The evolution of a small system is normally subjected to changing constraints, as set by a protocol, and involves a stochastic dependence on previous events. Here, we generalize the dynamic trajectories described by a realization of a physical system without dissipation to include those in which the history of previous events is necessary to understand its future. This framework is then used to characterize the processes experienced by the stochastic system, as derived from ensemble averages over the available pathways. We find that the pathways that the system traces in the presence of a protocol entail different statistics from those in its absence and prove that both types of pathways are equivalent in the limit of independent events. Such equivalence implies that a thermodynamic system cannot evolve away from equilibrium in the absence of memory. These results are useful to interpret single-molecule experiments in biophysics and other fields in nanoscience, as well as an adequate platform to describe non-equilibrium processes.
Assessing Efficiency of Public Poverty Policies in UE-28 with Linguistic Variables and Fuzzy Correlation Measures
Authors: de Andrés-Sánchez Jorge , Belzunegui-Eraso Angel , Valls-Fonayet Francesc
Published: January 2021

The present study analyzes the efficiency of social expenditure by EU-28 countries within the period 2014–2018 to reduce poverty. The data are provided by programs European Union Statistics on Income and Living Conditions (EU-SILC) and European System of Integrated Social Protection Statistics (ESSPROS) of Eurostat. We first calculate the Debreu–Farrell (DF) productivity measure similarly to our previous work, published in 2020, for each EU-28 country and rank these poverty policies (PPPs) on the basis of that efficiency index. We also quantify the intensity of the relationship between efficiency and the proportion that each item of social expending suppose within the overall. When evaluating public policies within a given number of years, we have available a longitudinal set of crisp observations (usually annual) for each embedded variable and country. The observed value of variables for any country for the whole period 2014–2018 is quantified as fuzzy numbers (FNs) that are built up by aggregating crisp annual observations on those variables within that period. To rank the efficiency of PPPs, we use the concept of the expected value of an FN. To assess the relation between DF index and the relative effort done in each type of social expense, we interpret Pearson’s correlation as a linguistic variable and also use Pearson’s correlation index between FNs proposed by D.H. Hong in 2006.
The Study of Events Approach Applied to the Impact of Mergers and Acquisitions on the Performance of Consulting Engineering Companies
Authors: Albuquerque Junior Marcos , Filipe José António , Jorge Neto Paulo de Melo , da Silva Cristiano
Published: January 2021

Recent research suggests that one of the main motivations for mergers and acquisitions is the attempt to acquire companies to incorporate intangible assets. Such assets provide important sources of sustainable competitive advantages and opportunities for growth. This article analyzes the strategies of engineering companies, as well as value creation in acquisition events of multinational companies, by using the study of the events method, providing an innovative way to be applied to this phenomenon. This method is used in our research to study the influence of the announcement of acquisitions on the abnormal accumulated returns of the acquiring companies, and is allowed to confirm that influence. In general, the average accumulated returns were positive and statistically significant in the three windows of the method, according to the significance tests used. The results validate the hypothesis that the events generate synergy gains for market players, emphasizing the importance of growth via acquisitions for the sector under analysis.
Method of Singular Integral Equations for Analysis of Strip Structures and Experimental Confirmation
Authors: Nickelson Liudmila , Pomarnacki Raimondas , Sledevič Tomyslav , Plonis Darius
Published: January 2021

This paper presents a rigorous solution of the Helmholtz equation for regular waveguide structures with the finite sizes of all cross-section elements that may have an arbitrary shape. The solution is based on the theory of Singular Integral Equations (SIE). The SIE method proposed here is used to find a solution to differential equations with a point source. This fundamental solution of the equations is then applied in an integral representation of the general solution for our boundary problem. The integral representation always satisfies the differential equations derived from the Maxwell’s ones and has unknown functions μe and μh that are determined by the implementation of appropriate boundary conditions. The waveguide structures under consideration may contain homogeneous isotropic materials such as dielectrics, semiconductors, metals, and so forth. The proposed algorithm based on the SIE method also allows us to compute waveguide structures containing materials with high losses. The proposed solution allows us to satisfy all boundary conditions on the contour separating materials with different constitutive parameters and the condition at infinity for open structures as well as the wave equation. In our solution, the longitudinal components of the electric and magnetic fields are expressed in the integral form with the kernel consisting of an unknown function μe or μh and the Hankel function of the second kind. It is important to note that the above-mentioned integral representation is transformed into the Cauchy type integrals with the density function μe or μh at certain singular points of the contour of integration. The properties and values of these integrals are known under certain conditions. Contours that limit different materials of waveguide elements are divided into small segments. The number of segments can determine the accuracy of the solution of a problem. We assume for simplicity that the unknown functions μe and μh, which we are looking for, are located in the middle of each segment. After writing down the boundary conditions for the central point of every segment of all contours, we receive a well-conditioned algebraic system of linear equations, by solving which we will define functions μe and μh that correspond to these central points. Knowing the densities μe, μh, it is easy to calculate the dispersion characteristics of the structure as well as the electromagnetic (EM) field distributions inside and outside the structure. The comparison of our calculations by the SIE method with experimental data is also presented in this paper.
Linear Algorithms for the Hosoya Index and Hosoya Matrix of a Tree
Authors: Vesel Aleksander
Published: January 2021

The Hosoya index of a graph is defined as the total number of its independent edge sets. This index is an important example of topological indices, a molecular-graph based structure descriptor that is of significant interest in combinatorial chemistry. The Hosoya index inspires the introduction of a matrix associated with a molecular acyclic graph called the Hosoya matrix. We propose a simple linear-time algorithm, which does not require pre-processing, to compute the Hosoya index of an arbitrary tree. A similar approach allows us to show that the Hosoya matrix can be computed in constant time per entry of the matrix.
Grid Frequency and Amplitude Control Using DFIG Wind Turbines in a Smart Grid
Authors: Cortajarena José Antonio , Barambones Oscar , Alkorta Patxi , Cortajarena Jon
Published: January 2021

Wind-generated energy is a fast-growing source of renewable energy use across the world. A dual-feed induction machine (DFIM) employed in wind generators provides active and reactive, dynamic and static energy support. In this document, the droop control system will be applied to adjust the amplitude and frequency of the grid following the guidelines established for the utility’s smart network supervisor. The wind generator will work with a maximum deloaded power curve, and depending on the reserved active power to compensate the frequency drift, the limit of the reactive power or the variation of the voltage amplitude will be explained. The aim of this paper is to show that the system presented theoretically works correctly on a real platform. The real-time experiments are presented on a test bench based on a 7.5 kW DFIG from Leroy Somer’s commercial machine that is typically used in industrial applications. A synchronous machine that emulates the wind profiles moves the shaft of the DFIG. The amplitude of the microgrid voltage at load variations is improved by regulating the reactive power of the DFIG and this is experimentally proven. The contribution of the active power with the characteristic of the droop control to the load variation is made by means of simulations. Previously, the simulations have been tested with the real system to ensure that the simulations performed faithfully reflect the real system. This is done using a platform based on a real-time interface with the DS1103 from dSPACE.
An Information-Theoretic Approach for Multivariate Skew-t Distributions and Applications
Authors: Abid Salah , Quaez Uday , Contreras-Reyes Javier
Published: January 2021

Shannon and Rényi entropies are two important measures of uncertainty for data analysis. These entropies have been studied for multivariate Student-t and skew-normal distributions. In this paper, we extend the Rényi entropy to multivariate skew-t and finite mixture of multivariate skew-t (FMST) distributions. This class of flexible distributions allows handling asymmetry and tail weight behavior simultaneously. We find upper and lower bounds of Rényi entropy for these families. Numerical simulations illustrate the results for several scenarios: symmetry/asymmetry and light/heavy-tails. Finally, we present applications of our findings to a swordfish length-weight dataset to illustrate the behavior of entropies of the FMST distribution. Comparisons with the counterparts—the finite mixture of multivariate skew-normal and normal distributions—are also presented.
Determination of Aircraft Cruise Altitude with Minimum Fuel Consumption and Time-to-Climb: An Approach with Terminal Residual Analysis
Authors: Kang Taehak , Ryu Jaiyoung
Published: January 2021

A pandemic situation of COVID-19 has made a cost-minimization strategy one of the utmost priorities for commercial airliners. A relevant scheme may involve the minimization of both the fuel- and time-related costs, and the climb trajectories of both objectives were optimized to determine the optimum aircraft cruise altitude. The Hermite-Simpson method among the direct collocation methods was employed to discretize the problem domain. Novel approaches of terminal residual analysis (TRA), and a modified version, m-σ TRA, were proposed to determine the goals. The multi-objective cruise altitude (MOCA) was different by 2.5%, compared to the one statistically calculated from the commercial airliner data. The present methods, TRA and m-σ TRA were powerful tools in finding a solution to this complex problem. The value σ also worked as a transition criterion between a single- and multi-objective climb path to the cruise altitude. The exemplary MOCA was determined to be 10.91 and 11.97 km at σ = 1.1 and 2.0, respectively. The cost index (CI) varied during a flight, a more realistic approach than the one with constant CI. With validated results in this study, TRA and m-σ TRA may also be effective solutions to determine the multi-objective solutions in other complex fields.
Estimating the Market Share for New Products with a Split Questionnaire Survey
Authors: Balmelli Simone , Moresino Francesco
Published: January 2021

When designing a new product, conjoint analysis is a powerful tool to estimate the perceived value of the prospects. However, it has a drawback: when the product has too many attributes and levels, it may be difficult to administrate the survey to respondents because they will be overwhelmed by the too numerous questions. In this paper, we propose an alternative approach that permits us to bypass this problem. Contrary to conjoint analysis, which estimates respondents’ utility functions, our approach directly estimates market shares. This enables us to split the questionnaire among respondents and, therefore, to reduce the burden on each respondent as much as desired. However, this new method has two weaknesses that conjoint analysis does not have: first, inferences on a single respondent cannot be made; second, the competition’s product profiles have to be known before administrating the survey. Therefore, our method has to be used when traditional methods are less easily implementable, i.e., when the number of attributes and levels is large.
Rare Chromone Derivatives from the Marine-Derived Penicillium citrinum with Anti-Cancer and Anti-Inflammatory Activities
Authors: Chu Yi-Cheng , Chang Chun-Hao , Liao Hsiang-Ruei , Cheng Ming-Jen , Wu Ming-Der , Fu Shu-Ling , Chen Jih-Jung
Published: January 2021

Three new and rare chromone derivatives, epiremisporine C (1), epiremisporine D (2), and epiremisporine E (3), were isolated from marine-derived Penicillium citrinum, together with four known compounds, epiremisporine B (4), penicitrinone A (5), 8-hydroxy-1-methoxycarbonyl-6-methylxanthone (6), and isoconiochaetone C (7). Among the isolated compounds, compounds 2–5 significantly decreased fMLP-induced superoxide anion generation by human neutrophils, with IC50 values of 6.39 ± 0.40, 8.28 ± 0.29, 3.62 ± 0.61, and 2.67 ± 0.10 μM, respectively. Compounds 3 and 4 exhibited cytotoxic activities with IC50 values of 43.82 ± 6.33 and 32.29 ± 4.83 μM, respectively, against non-small lung cancer cell (A549), and Western blot assay confirmed that compounds 3 and 4 markedly induced apoptosis of A549 cells, through Bcl-2, Bax, and caspase 3 signaling cascades.
Chemistry, Chemotaxonomy and Biological Activity of the Latrunculid Sponges (Order Poecilosclerida, Family Latrunculiidae)
Authors: Li Fengjie , Kelly Michelle , Tasdemir Deniz
Published: January 2021

Marine sponges are exceptionally prolific sources of natural products for the discovery and development of new drugs. Until now, sponges have contributed around 30% of all natural metabolites isolated from the marine environment. Family Latrunculiidae Topsent, 1922 (class Demospongiae Sollas, 1885, order Poecilosclerida Topsent, 1928) is a small sponge family comprising seven genera. Latrunculid sponges are recognized as the major reservoirs of diverse types of pyrroloiminoquinone-type alkaloids, with a myriad of biological activities, in particular, cytotoxicity, fuelling their exploration for anticancer drug discovery. Almost 100 pyrroloiminoquinone alkaloids and their structurally related compounds have been reported from the family Latrunculiidae. The systematics of latrunculid sponges has had a complex history, however it is now well understood. The pyrroloiminoquinone alkaloids have provided important chemotaxonomic characters for this sponge family. Latrunculid sponges have been reported to contain other types of metabolites, such as peptides (callipeltins), norditerpenes and norsesterpenes (trunculins) and macrolides (latrunculins), however, the sponges containing latrunculins and trunculins have been transferred to other sponge families. This review highlights a comprehensive literature survey spanning from the first chemical investigation of a New Zealand Latrunculia sp. in 1986 until August 2020, focusing on the chemical diversity and biological activities of secondary metabolites reported from the family Latrunculiidae. The biosynthetic (microbial) origin and the taxonomic significance of pyrroloiminoquinone related alkaloids are also discussed.
Bioactive Lipids of Marine Microalga Chlorococcum sp. SABC 012504 with Anti-Inflammatory and Anti-Thrombotic Activities
Authors: Shiels Katie , Tsoupras Alexandros , Lordan Ronan , Nasopoulou Constantina , Zabetakis Ioannis , Murray Patrick , Saha Sushanta Kumar
Published: January 2021

Microalgae are at the start of the food chain, and many are known producers of a significant amount of lipids with essential fatty acids. However, the bioactivity of microalgal lipids for anti-inflammatory and antithrombotic activities have rarely been investigated. Therefore, for a sustainable source of the above bioactive lipids, the present study was undertaken. The total lipids of microalga Chlorococcum sp., isolated from the Irish coast, were fractionated into neutral-, glyco-, and phospho-lipids, and were tested in vitro for their anti-inflammatory and antithrombotic activities. All tested lipid fractions showed strong anti-platelet-activating factor (PAF) and antithrombin activities in human platelets (half maximal inhibitory concentration (IC50) values ranging ~25–200 μg of lipid) with the highest activities in glyco- and phospho-lipid fractions. The structural analysis of the bioactive lipid fraction-2 revealed the presence of specific sulfoquinovosyl diacylglycerols (SQDG) bioactive molecules and the HexCer-t36:2 (t18:1/18:1 and 18:2/18:0) cerebrosides with a phytosphingosine (4-hydrosphinganine) base, while fraction-3 contained bioactive phosphatidylcholine (PC) and phosphatidylethanolamine (PE) molecules. These novel bioactive lipids of Chlorococcum sp. with putative health benefits may indicate that marine microalgae can be a sustainable alternative source for bioactive lipids production for food supplements and nutraceutical applications. However, further studies are required towards the commercial technology pathways development and biosafety analysis for the use of the microalga.
Engineering Bafilomycin High-Producers by Manipulating Regulatory and Biosynthetic Genes in the Marine Bacterium Streptomyces lohii
Authors: Li Zhong , Li Shuai , Du Lei , Zhang Xingwang , Jiang Yuanyuan , Liu Wenhua , Zhang Wei , Li Shengying
Published: January 2021

Bafilomycin A1 is the representative compound of the plecomacrolide natural product family. This 16-membered ring plecomacrolide has potent antifungal and vacuolar H+-ATPase inhibitory activities. In our previous work, we identified a bafilomycin biosynthetic gene cluster (baf) from the marine bacterium Streptomyces lohii ATCC BAA-1276, wherein a luxR family regulatory gene orf1 and an afsR family regulatory gene bafG were revealed based on bioinformatics analysis. In this study, the positive regulatory roles of orf1 and bafG for bafilomycin biosynthesis are characterized through gene inactivation and overexpression. Compared to the wild-type S. lohii strain, the knockout of either orf1 or bafG completely abolished the production of bafilomycins. The overexpression of orf1 or bafG led to 1.3- and 0.5-fold increased production of bafilomycins, respectively. A genetically engineered S. lohii strain (SLO-08) with orf1 overexpression and inactivation of the biosynthetic genes orf2 and orf3, solely produced bafilomycin A1 with the titer of 535.1 ± 25.0 mg/L in an optimized fermentation medium in shaking flasks. This recombinant strain holds considerable application potential in large-scale production of bafilomycin A1 for new drug development.
Fucoidan Structure and Its Impact on Glucose Metabolism: Implications for Diabetes and Cancer Therapy
Authors: Mabate Blessing , Daub Chantal Désirée , Malgas Samkelo , Edkins Adrienne Lesley , Pletschke Brett Ivan
Published: January 2021

Fucoidans are complex polysaccharides derived from brown seaweeds which consist of considerable proportions of L-fucose and other monosaccharides, and sulphated ester residues. The search for novel and natural bioproduct drugs (due to toxicity issues associated with chemotherapeutics) has led to the extensive study of fucoidan due to reports of it having several bioactive characteristics. Among other fucoidan bioactivities, antidiabetic and anticancer properties have received the most research attention in the past decade. However, the elucidation of the fucoidan structure and its biological activity is still vague. In addition, research has suggested that there is a link between diabetes and cancer; however, limited data exist where dual chemotherapeutic efforts are elucidated. This review provides an overview of glucose metabolism, which is the central process involved in the progression of both diseases. We also highlight potential therapeutic targets and show the relevance of fucoidan and its derivatives as a candidate for both cancer and diabetes therapy.
Risk Factors, Clinical Characteristics, and Prognosis of Acute Kidney Injury in Hospitalized COVID-19 Patients: A Retrospective Cohort Study
Authors: Hansrivijit Panupong , Gadhiya Kinjal P. , Gangireddy Mounika , Goldman John D.
Published: January 2021

Background: Acute kidney injury (AKI) is a serious complication of COVID-19. Methods: Records of hospitalized adult patients with confirmed SARS-CoV-2 infection from 1 March to 31 May 2020 were retrospectively reviewed. Results: Of 283 patients, AKI occurred in 40.6%. From multivariate analyses, the risk factors of AKI in COVID-19 can be divided into: (1) demographics/co-morbidities (male, increasing age, diabetes, chronic kidney disease); (2) other organ involvements (transaminitis, elevated troponin I, ST segment/T wave change on electrocardiography); (3) elevated biomarkers (ferritin, lactate dehydrogenase); (4) possible bacterial co-infection (leukocytosis, elevated procalcitonin); (5) need for advanced oxygen delivery (non-invasive positive pressure ventilation, mechanical ventilation); and (6) other critical features (ICU admission, need for vasopressors, acute respiratory distress syndrome). Most AKIs were due to pre-renal (70.4%) and intrinsic (34.8%) causes. Renal replacement therapy was more common in intrinsic AKI. Both pre-renal (HR 3.2; 95% CI 1.7–5.9) and intrinsic AKI (HR 7.7; 95% CI 3.6–16.3) were associated with higher mortality. Male, stage 3 AKI, higher baseline and peak serum creatinine and blood urea nitrogen were prevalent in intrinsic AKI. Urine analysis and the fractional excretion of sodium and urea were not helpful in distinguishing intrinsic AKI from other causes. Conclusions: AKI is very common in COVID-19 and is associated with higher mortality. Characterization of AKI is warranted due to its diverse nature and clinical outcome.
Frontline Healthcare Workers’ Knowledge, Perception and Risk Prevention Practices Regarding COVID-19 in Afghanistan: A Cross-Sectional Study
Authors: Bhagavathula Akshaya Srikanth , Raghavan Vijay R. , Ahmadi Akbar , Srirag Dipankar , Chattu Vijay Kumar
Published: January 2021

(1) Background: As of 13 December 2020, Afghanistan reported around 48,952 confirmed COVID-19 cases and 1960 deaths. Lack of knowledge and perceptions among healthcare workers (HCWs) can pose challenges to disease control. Therefore, targeted, timely assessment of knowledge and perceptions are needed to address practices that might hinder efforts to stop the spreading of COVID-19 in Afghanistan. This study aimed to assess COVID-19-related knowledge, perceptions, and risk prevention practices (KPP) among frontline HCWs in Afghanistan; (2) Methods: A cross-sectional study was conducted with the support of field teams who were deployed in Afghanistan, surveyed from 14 to 22 April 2020 in eight provinces in Afghanistan with varying cumulative incidence of COVID-19 cases. A 28-item KPP survey instrument was adapted from other internationally validated questionnaires related to COVID-19. (3) Results: The survey was conducted among 213 frontline HCWs engaged in screening and treating COVID-19 patients. Survey results indicated that basic awareness of COVID-19 was 100% across all the participants. Knowledge and understanding of COVID-19 transmission, symptoms, incubation period and complications associated with COVID-19 are comprehensive and high (>90%), except available treatment for COVID-19 (84%). HCWs’ perceptions towards the prevention and control of COVID-19 were positive. However, only 63% believed that the use of N-95 face masks and disposable and fluid-resistant gowns (76%) could prevent COVID-19 transmission. This survey showed high knowledge and positive perception (72%), and only 48% of frontline HCWs had shown risk prevention practices. Addressing their perceptions and placing additional focus on practices across all health facilities is recommended as a preparedness measure.
Trade-Off between Operating Time and Energy Consumption in Pulsed Electric Field Electrodialysis: A Comprehensive Simulation Study
Authors: Martí-Calatayud Manuel César , Sancho-Cirer Poczatek Mario , Pérez-Herranz Valentín
Published: January 2021

Electrodialysis (ED) has been recently introduced in a variety of processes where the recovery of valuable resources is needed; thus, enabling sustainable production routes for a circular economy. However, new applications of ED require optimized operating modes ensuring low energy consumptions. The application of pulsed electric field (PEF) electrodialysis has been demonstrated to be an effective option to modulate concentration polarization and reduce energy consumption in ED systems, but the savings in energy are usually attained by extending the operating time. In the present work, we conduct a comprehensive simulation study about the effects of PEF signal parameters on the time and energy consumption associated with ED processes. Ion transport of NaCl solutions through homogeneous cation-exchange membranes is simulated using a 1-D model solved by a finite-difference method. Increasing the pulse frequency up to a threshold value is effective in reducing the specific energy consumption, with threshold frequencies increasing with the applied current density. Varying the duty cycle causes opposed effects in the time and energy usage needed for a given ED operation. More interestingly, a new mode of PEF functions with the application of low values of current during the relaxation phases has been investigated. This novel PEF strategy has been demonstrated to simultaneously improve the time and the specific energy consumption of ED processes.