bluuebunny/crossref_metadata_2025 huggingface dataset:
Lise Öğrencilerinin Yansıma Dönüşümü Hakkındaki Matematiksel Söylemlerinin Öğretim Bağlamında Gelişimi
Authors: EMRE AKDOĞAN Elçin , GÜÇLER Beste , ARGÜN Ziya
Published: January 2020

Bu araştırmanın amacı, lise öğrencilerinin yansıma dönüşümü ile ilgili matematiksel söylemlerinin gelişimini ve söylem gelişiminin öğretimle olan ilişkisini ortaya koymaktır. Durum çalışması desenine sahip olan araştırmanın katılımcıları iki 10. sınıf öğrencisi ve bir öğretmendir. Araştırmanın verileri, öğretmen ve öğrencilerle yapılan görev temelli görüşmeler ve sınıf gözlemleri aracılığıyla sekiz haftada toplanmıştır. Verilerin analizi ise matematiksel bilişe iletişimsel yaklaşım teorisine göre yapılmıştır. Matematiksel bilişe iletişimsel yaklaşım teorisi bize öğretim ve öğrenme ile ilgili önemli perspektifler sunmuştur. Öğrencilerin yansıma dönüşümündeki söylemlerinin gelişiminin sınıfta öğretmenin kullandığı söylem ile karşılaştırmalı analizleri sonucunda, öğretmenin kullandığı söylemin, öğrencilerin söylemlerinin gelişimsel seviyesinin üstünde olduğu tespit edilmiştir. Ayrıca öğretmen ve öğrencilerin söylemleri arasında farklılıkların olduğu gözlemlenmiştir. Öğretmenin söylemlerinin açık ve anlaşılır olması durumunda öğrencilerin öğretmen söylemini kendilerine adapte edebildikleri, fakat öğretmenin söyleminde belli ögelerin üstünün örtük kaldığı durumlarda öğrencilerin söylemlerini öğretmenin söylemine adapte etmekte zorluk yaşadıkları ortaya çıkarılmıştır. Sınıf içerisindeki matematiksel iletişimi geliştirmek ve öğrencilerin söylemsel gelişimlerini desteklemek için öğretmenlerin, öğrencilerin söylemlerinin gelişimsel süreçlerinin farkında olması ve söylemlerini daha açık ve net bir hâle getirmeleri gerekmektedir.
PEMBERDAYAAN KEWIRAUSAHAAN SANTRI PADA PESANTREN YANBU'UL QUR'AN KUDUS
Authors: Nasir Amin
Published: January 2020

Entrepreneurship empowerment in pesantren is expected to have a positive impact, especially for santri or student. Empowerment is meaningful as an effort made by the Yanbu'ul Qur'an Islamic Boarding School Arwaniyah Foundation in introducing, fostering and developing the values of santri entrepreneurship and increasing students' interest in entrepreneurship. Entrepreneurship activities conducted are expected to foster the entrepreneurial character possessed by students. Entrepreneurial character is manifested in independence and leadership. With independence and leadership, students are expected to become role models for the surrounding community. Exemplary not only because they are graduates of Islamic boarding schools that are synonymous with da'wah activities, but also exemplary in economic activities by pocketing the entrepreneurial provision they have. Another goal with the provision of entrepreneurship is to improve the life skills of students. With the life skills that are owned, santri are felt ready when they enter the workforce later. Students are expected not only to depend on certain institutions to get jobs, but also can open their own jobs. By opening their own jobs, it will certainly open employment opportunities. This certainly can absorb unemployment in the community.
Pembelajaran Fisika Dasar Terintegrasi Nilai-Nilai Pendidikan Islam Melalui Diagram Vee
Authors: Pertiwi Faninda Novika
Published: January 2020

Penelitian ini dilatorbelakangi oleh pembelajaran Fisika yang selama ini dilakukan kurang bermakna. Selama ini pembelajaran Fisika yang dilakukan belum pernah diintegrasikan dengan nilai-nilai pendidikan Islam dan kurang melibatkan peserta didik dengan maksimal. Berdasarkan hal tersebut, makapada penelitian ini peneliti ingin mengimplementasikan pembelajaran Fisika dasar terintegrasi nilai-nilai pendidikan Islam melalui diagram Vee dengan tujuan agar tercipta pembelajaran yang bermakna. Penelitian ini merupakan penelitian tindakan kelas yang dilakukan selama 2 siklus. Materi Fisika yang disampaikan pada penelitian ini adalah kesetimbangan benda tegar, kalor, fluida dan gelombang. Subjek penelitiannya adalah mahasiswa IAIN Ponorogo, Jurusan Tarbiyah Prodi tadris IPA yang berjumlah 38 mahasiswa. Data hasil penelitian berupa hasil angket yang berkaitan dengan pembelajaran yang telah dilakukan. Berdasarkan hasil angket, terlihat bahwa setiap indikator dari pembelajaran bermakna mengalami peningkatan dari siklus 1 ke siklus 2. Peningkatan paling kecil terlihat pada indikator kemampuan menemukan jawaban sendiri dari suatu permasalahan yang ada yaitu sebesar 0,6%. Sedangkan peningkatan paling besar terlihat pada indikator kemampuan menghubungkan materi baru yang dipelajari dengan pengetahuan sebelumnya mengalami peningkatan paling besar yaitu sebesar 12,5%. Untuk indikator kemampuan menghubungkan materi yang dipelajari dengan salah satu ayat dalam Al-Qurâ€™an mengalami peningkatan sebesar  9 % dan yang terakhir indikator kemampuan mengaplikasikan materi yang dipelajari dalam kehidupan sehari-hari mengalami peningkatan sebesar 6,5 %. Secara keseluruhan, hasil penelitian menunjukkan bahwa pembelajaran bermakna dapat tercapai dengan mengintegrasikan materi Fisika dengan ayat Al-Qurâ€™an yang sesuai.Karena dengan begitu peserta didik lebih menghargai dan meyakini keteraturan alam ciptaan Tuhan. Hal ini sesuai dengan tujuan pendidikan IPA di Indonesia yaitu agar peserta didik memiliki keyakinan keteraturan alam ciptaan-Nya dan keagungan Tuhan YME.
Pengaruh Model Pembelajaran Student Active Learning dan Motivasi Berprestasi terhadap Kemampuan Menulis Karya tulis Ilmiah Mahasiswa (Eksperimen pada Mahasiswa Prodi Muamalah IAIN Ponorogo)
Authors: Hakim Lukman
Published: January 2020

Penelitian ini bertujuan untuk mengetahui Pengaruh Metode Active Learning dan Motivasi Berprestasi terhadap Kemampuan Menulis Karya Ilmiah Mahasiswa (Eksperimen pada mahasiswa Prodi Muamalah IAIN Ponorogo). Metode penelitian yang digunakan adalah eksperimen dengan rancangan faktorial 2Ã—2. Populasi penelitian ini adalah semua mahasiswa Prodi Muamalah IAIN Ponorogo. Sampel diambil dengan teknik two stage random sampling. Teknik pengumpulan data yang digunakan, yaitu tes dan nontes.Teknik analisis data yang digunakan adalah ANAVA Dua Jalan. Berdasarkan analisis data disimpulkan, pertama, kemampuan menulis karya ilmiah siswa yang diajar dengan metode Active Learning lebih baik daripada yang diajar dengan metode TCL (Teacher Centered Learning). Dari hasil Fh 8.31 > Ft sebesar 4.03 dengan db pembilang I dan db penyebut 50  pada taraf nyata 0.05. Kedua, kemampuan menulis karya ilmiah siswa yang memiliki motivasi berprestasi tinggi lebihbaik daripada kemampuan menulis karya ilmiah siswa yang memiliki motivasi berprestasi rendah. Dari hasil Fhsebesar 13.53 >Ftsebesar 4.03 dengan db pembilang I dan db penyebut 50  pada taraf nyata 0.05. Ketiga, ada interaksi antara metode pembelajaran dan motivasi berprestasi terhadap kemampuan menulis karya ilmiah. Dari hasil Fhsebesar 5.82 > Ft sebesar 4.03 dengan db pembilang I dan db penyebut50  pada taraf nyata 0.05.
Konsep Authentic Happiness pada Remaja dalam Perspektif Teori Myers
Authors: Rusdiana Ika
Published: January 2020

Fase remaja memiliki keunikan dalam menggambarkan diri mereka sendiri. Gambaran-gambaran remaja tentang dirinya sendiri kerap menimbulkan kerumitan dan sensitifitas emosional dalam hidup mereka, perluasan minat mengenai potret diri dan pencarian identitas selama masa remaja menjadikan remaja sebagai individu yang rawan mengalami konflik personal, interpersonal, dan sosial. Tulisan ini mencoba untuk menjelaskan bagaimana konsep authentic happiness remaja ditinjau dari perspektif teori Myers.  konsep authentic happiness remaja diukur berdasarkan empat indikator kebahagiaan menurut Myers yaitu: 1) mampu menghargai diri sendiri sepenuhnya, 2) sikap optimis, 3) sikap terbuka dan kemampuan bersosialisasi, dan 4)kemampuan mengontrol dan mengendalikan diri sendiri sepenuhnya. Subyek penelitian ini adalah mahasiswa IAIN Ponorogo dengan rentang usia antara 17-21 tahun. Hasil penelitian menunjukkan bahwa 11% (4 orang) remaja telah memiliki konsep authentic happiness positif (tinggi) sesuai indikator kebahagiaan Myers. 30% (11 orang) remaja telah memiliki konsep authentic happiness tingkat sedang, sementara 59% remaja memiliki konsep authentic happiness negatif. Dengan prosentase tersebut, remaja masih sangat rentan terhadap ancaman permasalahan-permasalahan, baik personal, interpersonal, dan sosial.
Menanamkan Nilai Pendidikan Karakter Pada Siswa Melalui Pembelajaran Sastra Dengan Model Permainan Gobak Sodor
Authors: Kirom Sabitul
Published: January 2020

Penelitian ini mendeskripsikan tentang pembelajaran sastra dengan model permainan gobak sodor dalam menanamkan nilai pendidikan karakter yang terfokus pada (1) pelaksanaan pembelajaran, (2) kendala yang dihadapi selama pembelajaran, dan (3) upaya yang dilakukan untuk mengatasi kendala tersebut. Penelitian ini termasuk ke dalam penelitian deskriptif kualitatif. Hasil penelitian ini menunjukkan bahwa guru melaksanakan pembelajaran sastra dengan model permainan gobak sodor untuk menanamkan nilai pendidikan karakter pada siswa. Kendala yang dialami guru yaitu guru susah mengatur peserta didik selama proses pembelajaran dan tempat yang digunakan sebagai arena untuk pembelajaran cukup luas. Guru mengatasi kendala tersebut dengan mengatur peserta didik secara tegas selama pembelajaran dan pengaturan jadwal dengan guru mata pelajaran lain.
Nilai-nilai Karakter dalam Novel Hafalan Sholat Delisa
Authors: Widada Dwi Masdi
Published: January 2020

Penelitian ini merupakan jenis penelitian kualitatif deskriptif dengan pendekatan nilai-nilai pendidikan budaya karakter bangsa. Teknik pengumpulan data menggunaka metode dokumentasi dan metode telaah teks. Metode dokumentasi dilaksanakan untuk mengumpulkan, memilah, mengolah, dan menyampaikan informasi untuk dapat mengkaji data selanjutnya.Analisis data dilakukan secara analisis isi. validitas data yang digunakan menggunakan trianggulasi data untuk mengumpulkan data yang sama. Artinya data yang sama atau sejenis akan lebih mantap kebenaranya bila digali dari beberapa sumber data yang berbeda. Novel HSD ditinjau dari strukturnya menceritakan kehidupan seseorang dari awal sampai meninggal, tema dalam novel ini banyak mengangkat tentang tema motivasi pendidikan dn hidup, rasa kemanuasiaan yang terekam sikap rasa simpati dan empati terhadap sesama. Peristiwa dalam novel ini terjadi di LhokNga dengan alur yang digunakan dalam novel maju. Amanat dalam novel ini adalah pentingnya hafalan bacaan shalat, sikap sabar dalam menghadapi cobaan apa pun, selalu bersyukur kepada Tuhan dalam keadaan suka dan duka. Kebutuhan aktualisasi diri dalam novel ditunjukkan adanya keinginan dalam diri tokoh untuk selalu mengaktualisasikan setiap cita-cita dan keinginannya untuk menghafalkan bacaan shalat dengan sempurna. Novel HSD sarat akan nilai pendidikan untuk pembacanya, terdiri dari nilai pendidikan agama yang menjelaskan hubungan manusia dengan Tuhannya, nilai moral yang mengatur baik buruknya perilaku manusia dalam hubungannya dengan sesama, nilai pendidikan sosial yang menunjukkan rasa peduli antar manusia satu dengan yang lain sesuai peranannya sebagai makhluk sosial; dan nilai pendidikan budaya bangsa yang menunjukkan kebiasaan dan cara pandang masyarakat dalam menjalani kehidupan.
Pengaruh Metode Membaca PQRST Terhadap Hasil Belajar Menyelesaikan Soal Cerita Mahasiswa PGSD UWKS
Authors: Damayanti Rini , Chamidah Amalia
Published: January 2020

Tujuan penelitian ini untuk membuktikan metode membaca pqrst berpengaruh terhadap hasil belajar mahasiswa pada materi soal cerita matematika. Instrumen pada penelitian ini adalah lembar tes. Jenis penelitian ini adalah kuantitatif dengan metode Eksperimen Semu (Quasi Experiment). Populasi dalam penelitian ini adalah mahasiswa semester 4 prodi Pendidikan Guru Sekolah Dasar Universitas Wijaya Kusuma Surabaya yang terdiri dari 2 kelas. Pemilihan sampel yang digunakan sebagai kelas eksperimen dan kelas kontrol dilakukan dengan teknik nonprabability sampling dengan teknik sampling jenuh dan terpilih semester IV-A sebagai kelas eksperimen dan semester IV-B sebagai kelas kontrol.

Hasil dari penelitian ini diperoleh nilai rata-rata kelas eksperimen yang diberi perlakuan metode membaca pqrst 80,66, sedangkan nilai rata-rata kelas kontrol yang diberi perlakuan metode pembelajaran konvensional 75,00. Hasil analisis Uji Independent Samples T-test menunjukkan bahwa nilai signifikan 0,008 < 0,05. Artinya H0 ditolak Ha diterima. Sehingga dapat disimpulkan bahwa ada pengaruh yang signifikan antara pemberian perlakuan berupa metode membaca pqrst terhadap hasil belajar mahasiswa pada materi soal cerita matematika.
Keefektifan Kalimat pada Lembar Jawaban UAS Mahasiswa IAIN Ponorogo dan Pemanfaatannya dalam Pembelajaran Bahasa Indonesia
Authors: Puspidalia Yuentie Sova
Published: January 2020

Dalam ujian tulis, tidak sedikit mahasiswa IAIN Ponorogo yang  cara menjawab dan menjelaskan gagasan-gagasannya membingungkan dan tidak menggunakan bahasa Indonesia dengan baik dan benar.  Hal ini menyebabkan dosen dalam mengoreksi menjadi gagal paham karena gagasan yang disampaikan sulit dimengerti. Salah satu penyebabnya  adalah ketidakefektifan kalimat yang digunakan. Maka dari itu, penelitian ini bertujuan  menjelaskan keefektifan kalimat berdasarkan tinjauan fonologi, morfologi, sintaksis/ gramatikal, semantik, dan leksikal serta menjelaskan kebermanfaatannya dalam pembelajaran bahasa Indonesia  di IAIN Ponorogo.  Untuk menyelesaikan penelitian ini, digunakan pendekatan kuali­ta­tif desktriptif. Teknik analisis data berupa analisis tekstual dan deskriptif. Hasilnya, ditemukan ketidakefektifan kalimat hampir pada semua aspek kebahasaan, baik dari ciri fonologis berkaitan dengan tanda baca (13, 96%) dan ejaan (67,69%), ciri morfologis (8,94%), ciri sintaksis (1,40%), ciri gramatikal (14,52%), ciri semantik (27,69%) maupun ciri leksikal (1,40%). Hasil penelitian ini dapat dimanfaatkan sebagai bahan evaluasi dosen pengampu dalam menerapkan pembelajaran bahasa Indonesia pada pokok bahasan kalimat efektif. Sebab, selama ini pembelajaran bahasa Indonesia di IAIN Ponorogo dirasa belum berhasil seratus persen. Hal ini dari kalimat-kalimat yang digunakan mahasiswa untuk menjawab soal-soal ujian akhir semester masih banyak yang tidak efektif.
Peran Kesenian Tradisional Dongkrek Sebagai Media Pendidikan Nilai Moral
Authors: Pahlevi Farida Sekti
Published: January 2020

Penelitian ini bertujuan untuk mengetahui dan mendeskripsikan tentang peran kesenian tradisional dongkrek sebagai media pendidikan nilai moral. Penelitian menggunakan metode deskriptif dengan pendekatan kualitatif. Alat pengumpulan data adalah wawancara, observasi, dan dokumentasi. Proses analisis data dengan mereduksi, menyajikan, dan menyimpulkan data. Hasil penelitian menunjukkan bahwa (a) kesenian tradisional Dongkrek tetap menjaga keaslian Kesenian tradisional Dongkrek; (b) Tata cara pagelaran kesenian tradisional Dongkrek di bagi menjadi tiga tahap yaitu tahap pra acara, tahap acara inti dan tahap penutupan; (c) Nilai moral yang terkandung dalam kesenian tradisional Dongkrek diantaranya adalah nilai kebersamaan/gotong royong, nilai keindahan, nilai kebenaran,nilai kebaikan, nilai tanggung jawab,nilai ketaatan, nilai keburukan atau kejahatan, nilai kejujuran, nilai kepercayaan; (d) Kesenian tradisional Dongkrek yang ada di Sanggar Krido Sakti tidak hanya sebagai ritual dan hiburan saja, tetapi dapat dijadikan sebagai media pendidikan pada waktu mengadakan latihan ataupun pagelaran; (e) Masyarakat Desa Mejayan sangat mendukung dikarenakan fungsi kesenian tradisional Dongkrek dinilai sangat potensial sebagai tontonan dan tuntunan bagi masyarakat.

Kata kunci: kesenian tradisional dongkrek, media pendidikan, nilai, moral
Menulis Teks Eksplanasi Ilmiah Dengan Menggunakan Media Media Flash Card
Authors: Setyawan Bambang
Published: January 2020

Kemampuan menulis kelas VI sekolah dasar adalah kemampuan menulis teks penjelasan (eksplanasi) dengan menggunakan kosa kata baku dan kalimat efektif. Namun pada kenyataannya, siswa kelas VI SDN Rejomulyo 1 Kras Kediri masih kesulitan menulis karangan, apalagi berupa teks eksplanasi ilmiah. Siswa membutuhkan media yang dapat   memfasilitasi daya imajinasinya untuk mengembangkan menjadi sebuah karangan. Penggunaan media flash card ini bertujuan untuk meningkatkan ketrampilan menulis teks eksplanasi ilmiah pada siswa kelas VI. Kemampuan mengembangkan teks eksplanasi ilmiah ini akan berpengaruh kepada kompetensi dasar yang lain, terutama yang berkaitan langsung dengan suatu gejala atau fenomena alam. Media ini dapat memfasilitasi siswa dalam  mengembangkan gagasannya kemudian menuangkan dalam kalimat efektif dengan  menggunakan kata-kata baku, sehingga siswa tidak mengalami kebuntuan dalam menulis kalimat. Karya inovasi media pembelajaran flash card ini menggunakan metode penelitian tindakan kelas selama dua siklus dan masing-masing siklus berlangsung selama dua pertemuan. Penelitian tindakan kelas ini menilai peningkatan kemampuan menulis teks ekplanasi ilmiah sebagai data utama. Setiap akhir pertemuan, siswa dinilai kemampuannya menulis teks eksplanasi ilmiah. Pada akhir siklus satu terjadi peningkatan rata-rata kelas sebesar 18,52 menjadi 75,37. Hasil siklus satu belum memenuhi indikator keberhasilan yang ditentukan karena belum mencapai ≥ 77,78 % jumlah siswa yang mengalami ketuntasan. Siklus kedua menunjukkan hasil bahwa terjadi peningkatan rata- rata kelas sebesar 10,74 dari siklus satu menjadi 86,11. Sehingga penggunaan media flash card kardus bekas ini mampu menaikkan ketrampilan menulis teks eksplanasi ilmiah sebesar 29,26.
Serum miR-101-3p combined with pepsinogen contributes to the early diagnosis of gastric cancer
Authors: Zeng Weiwei , Zhang Shuxiang , Yang Lei , Wei Wenchao , Gao Jie , Guo Ni , Wu Fengting
Published: January 2020

Background: This study aimed to explore the diagnostic value of serum miR-101-3p combined with pepsinogen (PG) on early diagnosis of gastric cancer (GC). Methods: A total of 61 atrophic gastritis (AG) and 86 GC patients, and 50 healthy volunteers were enrolled. The serum expression of miR-101-3p was measured by qRT-PCR. The serum content of carcinoembryonic antigen (CEA) was measured by Electrochemiluminescence immunoassay. The serum contents of PGI and PGII were measured by Enzyme linked immunosorbent assay. The diagnostic value of serum markers on AG and GC was analyzed by receiver operating characteristic (ROC) analysis. Results: The expression of miR-101-3p, the content of PGI and the ratio of PGI/II were significantly decreased, and the content of PGII was significantly increased in AG patients compared with those in normal controls. The changes of the above serum indicators were more obvious in GC patients than those in AG patients. The content of CEA was significantly higher in GC patients than that in AG patients. In addition, the expression of miR-101-3p was negatively associated with the submucosal infiltration in GC patients. MiR-101-3p exhibited high diagnostic value on AG (AUC 0.8493, sensitivity 80.33%, specificity 80%) and GC (AUC 0.8749, sensitivity 72.09%, specificity 86.49%). MiR-101-3p + PGI + PGI/II (AUC 0.856, sensitivity 80.23%, specificity 77.05%) exhibited a high diagnostic value in distinguishing between AG and GC. Conclusions: MiR-101-3p was a potential diagnostic marker for AG and GC. MiR-101-3p + PGI + PGI/II was effective in distinguishing between AG and GC.
Mortality in free-ranging Eurasian brown bears (Ursus arctos arctos) in Spain (1998-2018)
Authors: Balseiro Ana , Royo Luis José , Gayo Elena , Balsera Ramón , Alarcia Olga , Marín Juan Francisco García
Published: January 2020

Background This work summarizes the confirmed causes of death of twenty-five free-ranging Eurasian brown bears ( Ursus arctos arctos ) from the Cantabrian mountain range submitted for necropsy in Asturias and Castilla y León (northwestern Spain) from 1998 to 2018. Results Causes of death were classified based on (i) pathological findings and (ii) caused by “human intervention” or “non human intervention”. In four cases (16%) it was not possible to determine the cause of death due to the bad preservation of found remains or insufficient tissue availability. Based on pathological findings seven out of the 21 (33.3%) brown bears in which the cause of death could be determined died due to infectious diseases (clostridiosis n =4 or infectious canine hepatitis n =3), two (9.5%) due to exertional (degenerative) myopathy (one of those bears also showed clostridiosis) and one due to strychnine poisoning (4.8%), neoplasia (4.8%) or mushroom poisoning (4.8%). The remaining animals died due to traumatic lesions (including fights or infanticide), shooting or wire snare. Mortality data was also classified by deaths caused by “human intervention” or “non human intervention”. The death of one bear showing exertional myopathy after handling was not ascribed to any of the former classifications. Six out of the 20 (30%) brown bears died as a consequence of “human intervention” due to illegal hunting (wire snare hunting n =3 or shooting n =2) and, strychnine poisoning ( n =1). In contrast, fourteen (14/20, 70%) brown bears died by “non-human intervention”; nine of them (9/20, 45%) due to traumatic lesions (fights n =4, traumas n =3 or infanticide n =2), three (3/20, 15%) due to infectious canine hepatitis caused by canine adenovirus type 1 (CAdV-1) infection, one (1/20, 5%) due to cholangiocarcinoma and another one (5%) due to mushroom poisoning. Conclusions This study shows that the main causes of death in Eurasian brown bears are those caused by infectious diseases. In contrast to previous data on free-ranging bears for the first time infectious diseases appear as an important cause of death. These data are valuable and may help in the conservation and management of this recovering population.
The combined application of rat bone marrow mesenchymal stem cells and bioceramic materials in the regeneration of dental pulp-like tissues
Authors: Wen Ruixue , Wang Xin , Lu Yongchao , Du Yi , Yu Xijiao
Published: January 2020

Background: To observe the effects of combined application of rat bone marrow mesenchymal stem cells (rBMSCs) and a bioceramic material on pulp-like tissue formation. Methods: Rat incisor root fragments without pulp tissues were prepared and filled with a collagen scaffold seeded with rBMSCs, while one side of the root segment was covered by a bioceramic material (iRoot BP). After culture for 12 h, the root fragments were implanted subcutaneously for 3 months. Hematoxylin and eosin (HE) staining was applied to observe biocompatibility and the formation of pulp-like tissues. Incisor root fragments were divided into three parts (BP1/3 , M1/3, and D1/3) to analyze the area and number of new vessels. Immunohistochemical staining of neuroendocrine marker PGP9.5, dentin sialophosphoprotein ( DSPP ), and vascular endothelial growth factor (VEGF) was applied to observe the formation of pulp-like tissues. Root fragments filled with the collagen scaffold only were used as a control. Results: Three months after implantation, root fragments were collected, which were surrounded by a transparent tissue membrane with a good blood supply. The root fragment cavity was filled with pink vascularized pulp-like tissue. According to HE results, iRoot BP had good biocompatibility with new pulp-like tissues and few infiltrating inflammatory cells. Increases in the number and area of new blood vessels were observed in BP1/3 compared with the other two parts. Expression of PGP9.5 and DSPP showed that the newly formed tissues were similar to normal pulp tissues. Conclusion: iRoot BP has good biocompatibility and increases the number and area of new blood vessels. The combined application of stem cells and bioceramic materials may be a better method for pulp revascularization .
Motivational Interviewing and Self-care in Type 1 Diabetes:a randomized controlled clinical trial study protocol
Authors: Alvarado-Martel Dacil , Boronat Mauro , Alberiche María del Pino , Algara María Andrea , Wägner Ana M
Published: January 2020

BackgroundType 1 diabetes is a chronic disease with complex therapeutic recommendations that require day-to-day lifestyle changes. People with type 1 diabetes need to be involved in their health care in order to achieve satisfactory control of the condition. Motivational Interviewing is a communication tool that has been shown to be effective in changing behaviors in people with addictions, obesity and type 2 diabetes.Our objective is to evaluate the impact of a Motivational Interviewing intervention in patients with type 1 diabetes, through a randomized controlled clinical trial.MethodsSixty-six patients with type 1 diabetes and hemoglobin A1c>= 8% have been included and randomly assigned (computer-generated sequence, sealed envelopes, ratio 1:1) either to the intervention group or to the control group. In the intervention group, appointments every four months with the endocrinologist include Motivational Interviewing; in the control group, the appointments proceed as usual. Patients will be followed for 16 months.The primary outcome will be self-care behaviors, assessed according to a validated questionnaire, the Diabetes Self-Care Inventory-Revised Version. Secondary outcomes include: HbA1c, motivation for self-care, self-efficacy, health-related quality of life, satisfaction with professional-patient relationship, fulfillment of patients' own objectives and other sociodemographic and clinical variables related to disease control.The practitioners will receive training in Motivational Interviewing in order to help them promote adherence to self-care, encourage patient motivation and improve the doctor-patient relationship. The Motivational Interviewing intervention will be evaluated through videorecordings of the sessions and the administration of a purpose-built questionnaire, the EVEM 2.0 scale, by two psychologists, blinded to the assigned treatment. DiscussionThere is evidence that MI can improve self-care in type 2 diabetes. In T1D, however, its application has focused on adolescents, but, at present, there are no published data on the effect of MI in adults with T1D. In this study, we aim to evaluate the effect of MI on self-care and HbA1c.
Overexpression of Sideroflexin1 (SFXN1) Predicts Worse Overall Survival in Lung Adenocarcinoma
Authors: Liu Wenting , Jiang Kaiting , Wang Jingya , Mei Ting , Fan Xuehan , Zhang Yujia , Huang Dingzhi
Published: January 2020

BackgroundMitochondria are the core organelle of cellular energy and metabolism, also closely related to the growth and survival of cancer cells. This research aimed to discover and evaluate a promising prognostic biomarker, a novel mitochondrial gene—Sideroflexin1 (SFXN1), for lung adenocarcinoma (LUAD).ResultsAnalysis of 594 samples from The Cancer Genome Atlas (TCGA) Lung Cancer Cohort, this present study indicated that SFXN1/2/4/5 were overexpressed in LUAD tissue compared with normal lung tissue whereas only the SFXN1 was associated significantly with the overall survival (OS) from the Kaplan-Meier survival analysis (p=0.00093), suggesting that SFXN1 could be a potential prognostic biomarker. Furthermore, the logistic regression of the correlation of clinicopathological features and the expression status of SFXN1 from 522 patients with LUAD in TCGA revealed that the expression level of SFXN1 was related to Eastern Cooperative Oncology Group (ECOG), clinical stage, tumor size and lymph nodes invasion (all p<0.05). Additionally, overexpression of SFXN1 remained associated positively and independently with a worse prognosis after the multivariate Cox regression (HR=1.486, p=0.022). Functionally, SFXN1 involved in the cell cycle, specifically in DNA replication and meiosis, ATPase activity and folate-dependent one-carbon metabolism from the outcomes of Eastern Cooperative Oncology Group (KEGG) and Gene Ontology (GO) enrichment. ConclusionSFXN1 might promote the proliferation and metabolism of cancer cells and function as a prognostic indicator for LUAD, which may contribute to the development of targeted therapy and the emergence of metabolism-based treatment in clinical practice.
Association study of GFAP Polymorphisms with schizophrenia in Han Chinese population
Authors: Yu Wenjuan , he sidi , Yu Yimin , He Shen , Xu Qingqing , Yu Shunying , Huang Jingjing , Li huafang
Published: January 2020

INTRODUCTION Glial fibrillary acidic protein (GFAP) is considered to be an astrocyte activation marker. Alterations in structural and functional molecules expressed by astrocytes may play a role in the pathophysiology of schizophrenia (SCZ). In the present study, the single nucleotide polymorphisms (SNPs) of GFAP were analyzed for association with schizophrenia in Han population. METHODS Three tag SNPs within GFAP were genotyped in 629 SCZ patients and 655 healthy controls in the Han Chinese population.The schizophrenia database(SCZB) was used to investigate whether GFAP is differentially expressed in the brain regions of schizophrenia and healthy control individuals.In addition, expression quantitative trait loci(eQTL) analysis was used to investigate differential GFAP expression between different genotypes. RESULTSIt was shown that the rs3785891 GFAP polymorphism may be associated with schizophrenia ( p =0.04). There were no significant differences in the expression of hippocampal, prefrontal cortex or cortical GFAP between schizophrenia patients and control individuals. Furthermore,the brain eQTL analysis revealed a significant association between the rs3785891 polymorphism and GFAP expression in the intralobular white matter ( p = 0.04), thalamus ( p =0.024), hippocampus ( p =0.011), and occipital cortex ( p =0.0075). CONCLUSIONS This study shows that rs3785891 may be linked to schizophrenia susceptibility in the Han population. Further study is required for clarification the role of genetic variation around these SNPs in expression pattern of the GFAP gene, which may be involved in schizophrenia pathogenesis.
Incidence, bacteriological profile and antibiotic sensitivity pattern of neonatal sepsis in a tertiary health facility in Abuja, North-central Nigeria.
Authors: Oluyinka Olutunde , Airede Kareem I. , Olateju Kudi E. , Stephen Obaro K. , Izevbigie Nosakhare , Iloh Kenechukwu K. , Igbokwe Obianuju , Osuorah Chidiebere Donatus Ignatius
Published: January 2020

Background: Neonatal sepsis is commonly caused by bacteria in the first 28 days of life. If prompt management is not instituted, it could lead to death within hours of onset. Due to diagnostic limitation in developing settings, prompt laboratory identification of causative organism is usually a challenge. To prevent mortality, clear knowledge of bacteria and their antibiotics sensitivity pattern is important for prompt empirical treatment. Methods: This prospective and cross-sectional study enrolled 339 newborns and were admitted for probable sepsis to the special care unit of the university of Abuja Teaching Hospital. Socio-demographic profile and Blood culture was done from every enrolled newborn using BACTEC 9050. The pattern of the clinical features, incidence, bacteriological profile and antibiotic sensitivity pattern of newborns with confirmed neonatal sepsis were documented. Results: A total of 645 newborn were admitted for probable sepsis during the study period based on clinical features and initial laboratory work-up. Forty-six of the 645 newborns (46/645) had laboratory confirmed sepsis based on blood culture resulting in a neonatal sepsis incidence rate of 71.3 (95%CI 50.7-91.9) per 1000 admitted newborn. Seventeen of the 46 confirmed sepsis cases were among the 1322 newborns delivered within the study facility during the study period giving an in-hospital neonatal sepsis incidence rate of 12.9 (95% CI 6.7-19.0) per 1000 live birth. Amongst the 46 babies with positive blood culture, 27/46 (58.7%) had normal white cell count while the remaining 19/46 (41.3%) had abnormal results. In all, 52 counts of bacteria categorized into 11 bacteria species were isolated from the 46 positive blood cultures. Enterococcus spp and streptococcus species were the commonest gram-positive while Escherichia coli and Chryseomonas luteola were the commonest gram-negative bacteria isolates. Imipenem (all bacterial isolates except Vibrio fluvialis), Augmentin (Streptococcus spp, Staphylococcus spp, Escherichia spp, Enterococcus spp, Klebsiella spp, Moraxella catarrhalis, Acinetobacter baumannii), Vancomycin (Streptococcus spp, Staphylococcus spp, Escherichia spp, Enterococcus spp), and Ofloxacin (all except Vibrio fluvialis and Citrobacter freundii) had the widest coverage of bacteria isolated from newborn with sepsis. Conclusion: Sepsis in newborn is still prevalent in our environment and compared to previous documented isolates and sensitivity pattern, the bacteria causes, and their antibiotic sensitivity patterns appears to be changing.
Randomized controlled trial on the effect of Internet-based Cognitive Behavioral Therapy with Real-Time Therapist Support Via a Video Conference for patients with chronic pain: A study protocol
Authors: Taguchi Kayoko , Numata Noriko , Kutsuzawa Kana , Yoshimura Kensuke , Shimizu Eiji
Published: January 2020

Background: Chronic pain, which persists for at least 12 weeks, is a serious medical condition that not only causes numerous physical and mental conditions, but also affects a person's entire life. Previous studies concerning cognitive behavioral therapy for patients with chronic pain have shown low to intermediate effectiveness. This paper describes the study protocol for a randomized controlled trial (RCT) to evaluate the effectiveness of our newly developed Internet-based Cognitive Behavioral Therapy with Real-Time Therapist Support Via a Video Conference (vCBT) as an adjunct to usual care compared with only usual care for chronic pain. Methods: The RCT comprises two parallel groups (vCBT + usual care and usual care alone) of 20 participants each (n=40) who were diagnosed with chronic pain. We aim to evaluate the effectiveness of the intervention over 16 weeks. The primary outcome is pain intensity, which will be assessed by the Numerical Rating Scale (NRS) at week 16. Secondary outcomes are pain catastrophic perception and daily life impairment degree, each assessed by the Pain Catastrophizing Scale (PCS) and Pain Disability Assessment Scale (PADS). In addition, anxiety, depression, and quality of life will be assessed. All measures will be assessed at weeks 1 (baseline), 8 (middle), and 16 (post). Discussion: This study aims to demonstrate the effectiveness of Internet-based CBT with Real-Time Therapist Support Via a Video Conference for patients with chronic pain. The findings of this study will show a feasibility and safety of online CBT for chronic pain, valuable addition to the treatment options for these patients. And we expect that many therapists will be able to universally provide CBT of comparable quality in the treatment of chronic pain by using the CBT protocol which we have developed.
Ethanol in Food affects behaviour and HPA axis activity during development in zebrafish larvae Subhead: Ethanol in Food affects Nerves during development in zebrafish larvae
Authors: du wenxiao , Chen Xiaoli , Zhao Zhenjun , shi min , bian fuhua
Published: January 2020

Long-term alcohol intake from food can lead to numerous mental disorders in humans, and cause serious problems for governments and families worldwide. However, currently, it is unclear how alcohol affects the hypothalamic–pituitary–adrenal (HPA) axis. In the present study, using zebrafish larvae exposed to 1% ethanol, we made Zebrafish behavioural analysis, samples were collected for the enzyme-linked immunosorbent assay (ELISA) and quantitative real-time polymerase chain reaction (qRT-PCR) experiments,and made statistical analyses at last. we found that ethanol decreases the locomotor activity of zebrafish larvae,showed a more intense reaction to external stimuli,increases the secretion of HPA axis hormones in zebrafish larvae,influences the secretion of neurotransmitters,alters key gene expression during neurotransmitter metabolism. Ethanol exposure reduced zebrafish locomotor activity, increased their HPA axis activity, and led to significant changes in the secretion of dopamine and serotonin. These findings provide us with a new understanding of the effects of ethanol on the HPA axis.
Uninformed Decision Making and Regret About the Delay in Childbearing Decision Among Japanese Women and Men Seeking Fertility Treatment: A Cross-Sectional Study
Authors: Adachi Tomoko , Endo Masayuki , Ohashi Kazutomo
Published: January 2020

Background: In Japan, mean maternal and paternal ages at first birth have steadily increased over the past two decades, and more and more women and men seek fertility treatment. The aim of this study was to examine regret over the timing of the childbearing decision and reasons for its delay.Methods: This cross-sectional study included 219 women and 169 men referred to fertility facilities in Japan from July to December 2018. Participants completed a questionnaire on the reasons for their delay in childbearing decision and the degree of regret regarding their decision. Multiple linear regression was used to analyze the association between degree of regret and the reasons for the delay.Results: The top three reasons for the delay in childbearing decision in women were “Establishing the relationship,” “Health problems,” and “Financial security.” The top three reasons in men were “Establishing the relationship,” “Financial security,” and “Lack of fertility knowledge.” Lack of fertility knowledge was associated with regret over the timing of the childbearing decision in women (β = 0.232, 95% CI = 0.075-0.318, p = 0.002) and men (β = 0.238, 95% CI = 0.083-0.371, p = 0.002). In men, health problems was also associated with regret over the timing of the childbearing decision (β = 0.196; 95% CI = 0.039-0.332, p = 0.013).Conclusions: Uninformed decision making based on lack of fertility knowledge was significantly associated with regret later in life. It is important for early reproductive-aged women and men to have fertility knowledge in order to make an informed decision about the timing of childbearing to alleviate the possibility of experiencing regret later in life.Keywords: uninformed decision making, regret, delay in childbearing, fertility knowledge, preconception health
Oral prednisolone administration in postoperative period improves results of TKA in patient with severe range of motion limitation – a paired outcome study
Authors: Grzelecki Dariusz , Kowalczewski Jacek , Kordasiewicz Bartłomiej , Sibinski Marcin , Olewnik Łukasz , Marczak Dariusz
Published: January 2020

Background One of the most common problems related to total knee arthroplasty (TKA) is postoperatively limited range of motion, especially in the most difficult cases. The aim of the study was to assess the influence of oral use of prednisolone in the postoperative period on the final results in a patient after TKA with severely limited postoperative range of motion. Methods Thirty-two patients (32 knees) with a mean age of 61.2 years were selected from our prospectively-collected data base with severe knee range of motion limitation (rheumatoid arthritis, psoriasis, ankylosing spondylitis, posttraumatic and postoperative osteoarthritis). Prednisolone was administrated in two doses per day (1 mg per kg of body mass) and then the dose was slowly reduced for no more than three months. Results The prednisolone group demonstrated significantly better results one year after the operation than the non-prednisolone group in terms of range of motion (mean extension 0.5˚ and 3.0˚; p=0.02, mean flexion 100.1˚ and 88˚; p= 0.01), WOMAC (mean 85.0 and 76.8 points; p=0.02) and KSS clinical score (mean 86.9 and 81.7; p=0.001) and KSS functional score (79.3 and 71.0 points; p=0.01). No significant differences were observed between the groups in terms of postoperative systemic and surgical site complications; therefore, no complications could be defined as steroid related. Conclusions The administration of oral prednisolone for a longer postoperative time in patients with severe preoperative range of motion following TKA significantly improves functional results without steroid related complications at one year follow-up.
Levels of Biological Markers of Nitric Oxide in Serum of Patients with Mandible Factures
Authors: Ratajczak-Wrona Wioletta , Wozniak Lukasz , Borys Jan , Antonowicz Bozena , Nowak Karolina , Bortnik Piotr , Jablonska Ewa
Published: January 2020

Background Nitric oxide is a small gaseous molecule with significant bioactivity. It has been observed that NO may have a dual role dependent on its production and concentrations in the bone microenvironment. The objective of the study was to assess the concentration of total nitric oxide malonyldialdehyde, nitrotyrosine, and asymmetric dimethylarginine in the serum of patients with mandibular fractures and to understand the relationship between these compounds, in order to expand the knowledge base of the role of nitric oxide and its activity indicators in the process of bone fracture healing.Material and methods The study included patients with mandibular fractures who were undergoing inpatient and outpatient treatments. Results were analyzed with respect to the measurement time. Total nitric oxide concentration in the blood serum was determined according to the Griess reaction, while the concentration of malonyldialdehyde, nitrotyrosine, and asymmetric dimethylarginine was estimated using the immunoenzymatic method (i.e. enzyme-linked immunosorbent assay).Results Before procedure as well as on the first day and 2 and 6 weeks after the procedure, higher concentrations of total nitric oxide and lower concentrations of malonyldialdehyde were observed in the blood serum of patients with mandibular fractures compared to the control group. No statistically significant differences were found in nitrotyrosine concentrations in the blood serum of patients throughout the measurement period. However, a significantly higher asymmetric dimethylarginine concentration was observed in the patient serum before the procedure and on the first day of operation as compared with the control group. Analysis of the results observed in patient serum with respect to the number of fractures within the mandible demonstrated the same trend of concentrations for the tested compounds for the entire study group.Conclusions In summary, our results revealed that the intensity of local processes resulting from mandibular fractures is associated with the concentration of nitric oxide, confirming its significant role, as well as that of its indicators, in the process of bone fracture healing in this patient population.
Bone mineral density and bone metabolism in postmenopausal women with type 2 diabetes in a Chinese community: a cross-sectional study
Authors: Han Wu , Zhang Yufan , Zhou Wenbin , Dai Jing , Yao Tao , Xu Jingjing , He Wei
Published: January 2020

AMI: There is growing evidence of a complex interaction between T2DM and osteoporosis. The purpose of this study was to further study the relationship between BTMs and fasting blood glucose (FBG) in postmenopausal patients with type 2 diabetes and to analyze the effect of hyperglycemia on bone metabolism. Methods: Six hundred and twelve (612) postmenopausal women were included, including one hundred and seven (107) subjects with T2DM and five hundred and five (505) subjects without diabetes. BMD was measured by DXA (dual-energy X-ray absorptiometry). Markers of bone formation (P1NP) and resorption ( CTX ) were quantified. Results: Compared to controls, postmenopausal women with diabetes had a higher prevalence of previous osteoporosis fracture (27.1% vs. 17.4% for diabetic and nondiabetic women, respectively) and a higher BMD. The P1NP level in women with T2DM was 49.451 ng/ml, while in N-DM individuals, it was 58.633 ng/ml, (p = 0.017). The CTX level in women with T2DM was 0.325 ng/ml, while in N-DM individuals, it was 0.412 ng/ml (p=0.039). In addition, P1NP was significantly negatively associated with age (β=-0.590; p= 0.002) and FBG (β=-1.950; p = 0.035). CTX was negatively associated with FBG (β=-0.029; p = 0.015). Conclusions: T2DM was associated with higher BMD and paradoxically, with an increased risk of fracture. Postmenopausal women with T2DM had lower bone turnover than controls. With increased levels of FBG, bone formation and bone resorption were reduced, and the overall bone turnover level was reduced. Keywords Type 2 diabetes mellitus · Bone mineral density · Bone turnover markers · Osteoporosis fracture
Associations of heavy metal levels with environmental and behavioral factors in children with autism spectrum disorder
Authors: Xiao Yu , Huang Yongshun , Huang Weiyong , Zhao Chang’an , Hu Ligang , Chen Baowei , Deng Yuhong , Zhu Dongsheng , He Yansi , Tang Qinli , Ouyang Kai , Ma Danjuan , Huang Jian , Wu Jieling , Chen Jiabin , Huang Hanlin
Published: January 2020

Background The etiologies of autism spectrum disorder (ASD) are yet unclear. Previous studies suggested that ASD is associated with environmental heavy metals. Thus, the present study analyzed the levels of 41 heavy metals and the associated environmental factors in children with ASD. Methods The 25 children diagnosed with ASD were included in the case group (ASD group), while the 18 age- and gender-matched healthy children who came for routine care were included in the typical development group (TD group). The levels of heavy metal in the blood were measured in both groups. The questionnaire survey collected the demographic information, socioeconomic information, and risk factors of potential heavy metal sources for the analysis of risk factors. Results A total of 25 children were included in the ASD group and 18 in the TD group. The blood manganese (Mn) level was significantly higher in the ASD group than the TD group . The father’s educational level was significantly higher in the ASD group than the TD group. The living status was mainly scattered for the ASD children and daycare for the TD group. The frequency of book-reading, washing hand with sanitizer/soap, and the folic acid intake by the mother before pregnancy was significantly lower in the ASD group than the TD group, while the percentage of birth disorder history was significantly higher in the ASD group than the TD group. Binary logistic regression analysis showed that the folic acid intake by the mother before pregnancy and father’s education level beyond junior college were protective factors for ASD. Also, the frequencies of washing hands with sanitizer every time, sometimes, and hardly acted as protective factors for ASD. Conclusion Blood Mn level was significantly higher in ASD than TD, suggesting that environmental Mn exposure could be a risk factor of ASD in children. Folic acid intake by the mother before pregnancy and father’s education levels are protective factors for ASD. Concentrated heavy metal in the blood in prenatal or early life exposures which suggested ASD is needed in the future study.