bluuebunny/crossref_metadata_2025 huggingface dataset:
Causal Relationship between Diet-Induced Gut Microbiota Changes and Diabetes: A Novel Strategy to Transplant Faecalibacterium prausnitzii in Preventing Diabetes
Authors: Ganesan Kumar , Chung Sookja Kim , Vanamala Jairam , Xu Baojun
Published: November 2018

The incidence of metabolic disorders, including diabetes, has elevated exponentially during the last decades and enhanced the risk of a variety of complications, such as diabetes and cardiovascular diseases. In the present review, we have highlighted the new insights on the complex relationships between diet-induced modulation of gut microbiota and metabolic disorders, including diabetes. Literature from various library databases and electronic searches (ScienceDirect, PubMed, and Google Scholar) were randomly collected. There exists a complex relationship between diet and gut microbiota, which alters the energy balance, health impacts, and autoimmunity, further causes inflammation and metabolic dysfunction, including diabetes. Faecalibacterium prausnitzii is a butyrate-producing bacterium, which plays a vital role in diabetes. Transplantation of F. prausnitzii has been used as an intervention strategy to treat dysbiosis of the gut’s microbial community that is linked to the inflammation, which precedes autoimmune disease and diabetes. The review focuses on literature that highlights the benefits of the microbiota especially, the abundant of F. prausnitzii in protecting the gut microbiota pattern and its therapeutic potential against inflammation and diabetes.
Complementary Quantitative Structure–Activity Relationship Models for the Antitrypanosomal Activity of Sesquiterpene Lactones
Authors: Kimani Njogu M. , Matasyoh Josphat C. , Kaiser Marcel , Nogueira Mauro S. , Trossini Gustavo H. G. , Schmidt Thomas J.
Published: November 2018

Three complementary quantitative structure–activity relationship (QSAR) methodologies, namely, regression modeling based on (i) “classical” molecular descriptors, (ii) 3D pharmacophore features, and (iii) 2D molecular holograms (HQSAR) were employed on the antitrypanosomal activity of sesquiterpene lactones (STLs) toward Trypanosoma brucei rhodesiense (Tbr), the causative agent of the East African form of human African trypanosomiasis. In this study, an extension of a previous QSAR study on 69 STLs, models for a much larger and more diverse set of such natural products, now comprising 130 STLs of various structural subclasses, were established. The extended data set comprises a variety of STLs isolated and tested for antitrypanosomal activity within our group and is furthermore enhanced by 12 compounds obtained from literature, which have been tested in the same laboratory under identical conditions. Detailed QSAR analyses yielded models with comparable and good internal and external predictive ability. For a set of compounds as chemically diverse as the one under study, the models exhibited good coefficients of determination (R2) ranging from 0.71 to 0.85, as well as internal (leave-one-out Q2 values ranging from 0.62 to 0.72) and external validation coefficients (P2 values ranging from 0.54 to 0.73). The contributions of the various tested descriptors to the generated models are in good agreement with the results of previous QSAR studies and corroborate the fact that the antitrypanosomal activity of STLs is very much dependent on the presence and relative position of reactive enone groups within the molecular structure but is influenced by their hydrophilic/hydrophobic properties and molecular shape.
Most Women with Previous Gestational Diabetes Mellitus Have Impaired Glucose Metabolism after a Decade
Authors: Jeanette Wahlberg , Bertil Ekman , Hans Arnqvist J.
Published: November 2018

Of 1324 women diagnosed with gestational diabetes mellitus (GDM) in Sweden, 25% reported >10 years after the delivery that they had developed diabetes mellitus. We assessed the long-term risk of all glucose metabolic abnormalities in a subgroup of these women. Women (n = 51) previously diagnosed with GDM by capillary blood glucose ≥9.0 mmol/L (≈plasma glucose ≥10.0 mmol/L) after a 2 h 75 g oral glucose tolerance test (OGTT) were included. All underwent a clinical and biochemical evaluation, including a second 2 h 75 g OGTT. Individuals with known type 1 diabetes were excluded. At the follow-up, 12/51 (24%) reported previously diagnosed type 2 diabetes. Another four cases were diagnosed after the second OGTT, increasing the prevalence to 16/51 cases (31%). Impaired fasting plasma glucose (IFG) was diagnosed in 13/51 women and impaired glucose tolerance (IGT) in 10/51 women, leaving only 12 women (24%) with normal glucose tolerance. In addition, 2/51 women had high levels of glutamic acid decarboxylase (GAD) antibodies; of these, one woman classified as type 2 diabetes was reclassified as type 1 diabetes, and the second GAD-positive woman was diagnosed with IGT. Of the women diagnosed with GDM by a 2 h 75 g OGTT, a large proportion had impaired glucose metabolism a decade later, including type 1 and type 2 diabetes.
Relationship of Circulating Irisin with Body Composition, Physical Activity, and Cardiovascular and Metabolic Disorders in the Pediatric Population
Authors: Elizondo-Montemayor Leticia , Mendoza-Lara Gerardo , Gutierrez-DelBosque Gustavo , Peschard-Franco Mariana , Nieblas Bianca , Garcia-Rivas Gerardo
Published: November 2018

Exercise-induced irisin, a recently discovered myokine, has been linked to insulin resistance, obesity, and other diseases in adults; however, information in children is scarce and contradictory. We analyzed the limited evidence of irisin’s effects in children and adolescents, and its association with body composition, exercise training, cardiovascular risk factors, and metabolic diseases, as well as the results of dietetic interventions. Both positive and negative correlations between irisin concentrations and body mass index, fat mass, fat-free mass, and other anthropometric parameters were found. Likewise, contradictory evidence was shown associating irisin plasma levels with cardiovascular and metabolic parameters such as glucose, insulin resistance, and cholesterol and other lipid and fatty acid plasma levels in healthy children, as well as in those with obesity and the metabolic syndrome. Gender, puberty, and hormonal differences were also examined. Furthermore, important contradictory findings according to the type and duration of exercise and of dietetic interventions in healthy and unhealthy subjects were demonstrated. In addition, correlations between mother–infant relations and circulating irisin were also identified. This review discusses the potential role of irisin in health and disease in the pediatric population.
Heterogeneity in Colorectal Cancer: A Challenge for Personalized Medicine?
Authors: Molinari Chiara , Marisi Giorgia , Passardi Alessandro , Matteucci Laura , De Maio Giulia , Ulivi Paola
Published: November 2018

High inter-patient variability and high spatial heterogeneity are features of colorectal cancer (CRC). This may influence the molecular characterization of tumor tissue, now mandatory for patients with metastatic CRC who are candidates for treatment with an anti-EGFR mAb, as false-negative results can occur, leading to non optimal therapy. Moreover, temporal molecular heterogeneity during treatment is known to influence the response to therapy and prognosis. We present a literature overview of advances made in characterizing molecular heterogeneity in CRC, underlining that the analysis of liquid biopsy could represent an efficient non-invasive tool to overcome the problem. We believe that understanding CRC heterogeneity is fundamental for a more accurate diagnosis, for selecting the best targets to ensure prolonged antitumor response, and for monitoring minimal residual disease and the onset of resistance to therapy, all essential components of successful personalized treatment.
Study on the Preparation and Chemical Structure Characterization of Melanin from Boletus griseus
Authors: Liu Qiuming , Xiao Junjiang , Liu Bingtong , Zhuang Yongliang , Sun Liping
Published: November 2018

In this study, melanin (BgM) was obtained from Boletus griseus. The chemical composition and structure of BgM were characterized by UV-visible absorption spectrum, Fourier transform infrared spectrum, elemental analysis, nuclear magnetic resonance, pyrolysis gas chromatography mass spectrometry, and ultra-performance liquid chromatography–high resolution mass spectrometry. The percentage contents of C, H, N, S and O elements were 56.38%, 5.86%, 6.17%, 2.44%, and 28.04%, and the S/N and C/N ratios were 0.17 and 10.66, respectively. The UV-vis spectrum of BgM showed a maximum absorption peak at 214 nm. Characteristic absorption peaks were observed at 3426, 1600 and 1105 cm−1, and BgM contained phenolic hydroxyl, amidogen, carbonyl, methylene, and methyl groups. Moreover, BgM is an eumelanin, and its main skeleton has both a benzene ring and an indole, and the branched chain mainly consists of alkanes, alcohols, and fatty acids. BgM was hydrolyzed by H2O2 and four compounds were tentatively analyzed from the UPLC-MS/MS profile. The chemical structure of BgM was characterized as 5,6-dihydroxyindole eumelanin, and the condensed molecular formula is [C28(OR1)4(OR2)3H11O6N4]n.
A Compression-Based Toolkit for Modelling and Processing Natural Language Text
Authors: Teahan William John
Published: November 2018

A novel compression-based toolkit for modelling and processing natural language text is described. The design of the toolkit adopts an encoding perspective—applications are considered to be problems in searching for the best encoding of different transformations of the source text into the target text. This paper describes a two phase ‘noiseless channel model’ architecture that underpins the toolkit which models the text processing as a lossless communication down a noise-free channel. The transformation and encoding that is performed in the first phase must be both lossless and reversible. The role of the verification and decoding second phase is to verify the correctness of the communication of the target text that is produced by the application. This paper argues that this encoding approach has several advantages over the decoding approach of the standard noisy channel model. The concepts abstracted by the toolkit’s design are explained together with details of the library calls. The pseudo-code for a number of algorithms is also described for the applications that the toolkit implements including encoding, decoding, classification, training (model building), parallel sentence alignment, word segmentation and language segmentation. Some experimental results, implementation details, memory usage and execution speeds are also discussed for these applications.
Effect of Combined Treatment of Ketorolac and Remote Ischemic Preconditioning on Renal Ischemia-Reperfusion Injury in Patients Undergoing Partial Nephrectomy: Pilot Study
Authors: Kil Hae Keum , Kim Ji Young , Choi Young Deuk , Lee Hye Sun , Kim Tae Kwang , Kim Ji Eun
Published: November 2018

We evaluated postoperative renal function in patients with/without combined therapy of ketorolac and remote ischemic preconditioning during partial nephrectomy. Sixteen patients were randomly allocated to either the ketorolac combined with RIPC group (KI, n = 8) or control group (n = 8). The KI group received both remote ischemic preconditioning before surgery and intravenous ketorolac of 1 mg/kg before renal artery clamping. Renal parameters were measured before induction, after anesthesia induction, and 2, 12, 24, 48, and 72 h after renal artery declamping. Acute kidney injury was assessed by Acute Kidney Injury Network criteria. The estimated glomerular filtration rate decreased in both groups, but then increased significantly at 48 h and 72 h after declamping only in the KI group compared to 24 h (p = 0.001 and p = 0.016). Additionally, it was higher at 48 h and 72 h after declamping in the KI group compared to the control group (p = 0.025 and p = 0.044). The incidence of acute kidney injury was significantly reduced in the KI group (13%) compared to the control group (83%) (p = 0.026). FENa was markedly increased at 2 h after declamping, and recovered in both groups, but it was more significant at 12 h after declamping in the KI group (p = 0.022). Urinary N-acetyl-1-β-D-glucosoaminidase and serum neutrophil gelatinase-associated lipocalin were similar (p = 0.291 and p = 0.818). There is a possibility that combined therapy of ketorolac and remote ischemic preconditioning prior to ischemia may alleviate renal dysfunction and reduce the incidence of acute kidney injury in patients undergoing partial nephrectomy.
Lipid Myopathies
Authors: Pennisi Elena Maria , Garibaldi Matteo , Antonini Giovanni
Published: November 2018

Disorders of lipid metabolism affect several tissues, including skeletal and cardiac muscle tissues. Lipid myopathies (LM) are rare multi-systemic diseases, which most often are due to genetic defects. Clinically, LM can have acute or chronic clinical presentation. Disease onset can occur in all ages, from early stages of life to late-adult onset, showing with a wide spectrum of clinical symptoms. Muscular involvement can be fluctuant or stable and can manifest as fatigue, exercise intolerance and muscular weakness. Muscular atrophy is rarely present. Acute muscular exacerbations, resulting in rhabdomyolysis crisis are triggered by several factors. Several classifications of lipid myopathies have been proposed, based on clinical involvement, biochemical defect or histopathological findings. Herein, we propose a full revision of all the main clinical entities of lipid metabolism disorders with a muscle involvement, also including some those disorders of fatty acid oxidation (FAO) with muscular symptoms not included among previous lipid myopathies classifications.
The Interpretation of Adjective-N Sequences in Spanish Heritage
Authors: Camacho José
Published: November 2018

Adjectives appear predominantly postnominally in Spanish, and when prenominal, cannot be interpreted as restrictive. We explore whether heritage speakers of Spanish have the same interpretive and ordering restriction as monolinguals. Twenty-two US college-age heritage speakers and 17 college-age monolinguals from Peru completed a rating task that manipulated word order and interpretation. Items varied in word order (Adj-N/N-Adj) and interpretation (restrictive-only, color and nationality adjectives, and ambiguous adjectives, restrictive and non-restrictive), all framed within a context that favored a restrictive interpretation. Both groups judged Adj-N orders lower than N-Adj orders, and restrictive adjectives lower in prenominal position than ambiguous adjectives. Consequently, we argue that heritage speakers (HS) have the relevant knowledge regarding word order and interpretation, and the interactions among the two properties. We propose a syntactic representation involving NP-raising for both groups, and suggest that in some cases, the higher copy of the NP is deleted, resulting in the linear order Adj-N. We also argue that this analysis may explain the range of individual variation across heritage speakers.
Tether Space Mobility Device Attitude Control during Tether Extension and Winding
Authors: Takehara Shoichiro , Uematsu Yu , Miyaji Wataru
Published: November 2018

Recently, advancements in space technology have opened up more opportunities for human beings to work in outer space. It is expected that upsizing of manned space facilities, such as the International Space Station, will further this trend. Therefore, a unique means of transportation is necessary to ensure that human beings can move about effectively in microgravity environments. In the present study, we propose a tether-based mobility system, which moves the user by winding a tether attached to a structure at the destination. However, there is a problem in that the attitude of the user becomes unstable during winding of the tether. Therefore, a Tether Space Mobility Device (TSMD) attitude control method for winding a tether is examined through numerical analysis. The proposed analytical model consists of one flexible body and three rigid bodies. The contact force between the tether and the inlet is considered. We verified the validity of the proposed model through experiments. Furthermore, we proposed a TSMD attitude control method during tether winding while focusing on changes in the system’s rotational kinetic energy. Using the proposed analytical model, the angular velocity of a rigid body system is confirmed to converge to 0 deg/s when control is applied.
The scientific heritage of Professor Aron Gutman (Commemorating the 10th anniversary of Aron Gutman’s death)
Authors: Baginskas Armuntas , Svirskis Gytis , Miliauskas Rimvydas
Published: November 2018

Aron Gutman started his scientific research when he was a student of the Department of Physics and Mathematics, Vilnius University. At that time, he developed the theory of nonhomogenous vector relations between magnetic moments of electrons in an atom and applied it for explanation of energy spectrum of real atoms. Since 1960, he worked in Kaunas Medical Institute, and his main field of scientific interests was theoretical biophysics and electrophysiology of living tissues and cells. The earlier biophysical works of A. Gutman dealt with problems of the bioelectrical fields that underlie electroencephalogram, electrocorticogram, and electrocardiogram. The most important achievement was a theory of individual potential or postsynaptic field potential of synapses from individual axon (EEG quantum) and its role in shaping of electroencephalogram. In the later works (from 1971), he looked into properties and function of the individual nerve cells. He had created and developed the theory of nonlinear (bistable) dendrites and analyzed functional implications of such dendrites. In the last works, A. Gutman tried to relate the functioning of the nervous system at the cellular and system levels. He made efforts to find connection between the properties of individual neurones and principles (laws) of functioning of the nervous system. He had managed to relate dendritic bistability of neurones and Gelfand-Tsetlin principle of the functioning of the central nervous system (also known as the principle of minimal afferentiation). He explained some regularities in motor control by the dendritic bistability of motoneurones.
Association between Diabetic Retinopathy and Chronic Periodontitis—A Cross-Sectional Study
Authors: H. R. Veena , Natesh Sribhargava , Patil Sudhir R.
Published: November 2018

Periodontal disease (PD), a chronic inflammatory condition characterized by destruction of the supporting tissues of the teeth, increases the risk of complications in diabetics. Diabetic retinopathy (DR) is a microvascular complication of prolonged hyperglycaemia. There appears to be a similarity in the pathogenesis of DR and PD. Hence, this study aimed to investigate the association, if any, between DR and PD, correlate the severity of DR with the severity of PD, and investigate the association between glycated haemoglobin (HbA1c), serum creatinine and periodontal variables. The periodontal status of 200 adult diabetic patients in the age group of 30–65 years with varying severity of DR was assessed. Evaluation of the severity of PD was assessed by recording clinical parameters. Haematological investigations including glycated haemoglobin (HbA1c) and serum creatinine were estimated before the initiation of treatment for DR. A statistically significant association between the mean duration of diabetes mellitus (DM) and the severity of DR and PD was found. The severity of PD was directly correlated with the severity of DR. There was a significant association between the levels of HbA1c and serum creatinine and severity of DR and PD. There could be a plausible relationship between DR and PD. Further prospective studies on a larger population with longer follow-ups are required to ascertain whether PD and its severity directly affect the progression and severity of DR.
Impact of Dynamic Non-Equilibrium Processes on Fracture Mechanisms of High-Strength Titanium Alloy VT23
Authors: Maruschak Pavlo , Konovalenko Ihor , Chausov Mykola , Pylypenko Andrii , Panin Sergey , Vlasov Ilya , Prentkovskis Olegas
Published: November 2018

The complex analysis of fractures of high-strength titanium alloy VT23 was performed at the macro- and microlevels, and the basic patterns of fracture under static stretching and after the realization of dynamic non-equilibrium processes caused by impact-oscillatory loading and subsequent static stretching were revealed. The morphological regularities in the formation of dimples of tearing and alloy stratification at the macro level were established with the help of 3-D profilometry. The micromechanisms of fracture were numerically characterized by the methods of optical-digital analysis, in particular, by highlighting the bound areas, which are the objects of interest—the dimples of tearing. The analysis of the surface of ductile tearing under different loading conditions at the microlevel was performed by analyzing the parameter distribution patterns of the dimples found on it.
The Effect of Different Arc Currents on the Microstructure and Tribological Behaviors of Cu Particle Composite Coating Synthesized on GCr15 Steel by PTA Surface Alloying
Authors: Xiong Yibo , Lin Dongqing , Zheng Zhizhen , Li Jianjun , Deng Tiantian
Published: November 2018

In order to improve the tribological performance of the slanted guide pillar, Cu particle reinforced composite coatings were synthesized on the surface of GCr15 steel using the plasma transferred arc (PTA) alloying technique. A systematic experimental investigation was conducted to study the effects of PTA current on the microstructure and microhardness of alloyed coatings. In addition, tribological behaviors at room temperature (RT) and high temperature (HT) were investigated. The results indicate that at low PTA current (70A), due to the insufficient current, no Cu particles are dissolved in the alloyed coating and a Cu-rich layer is observed on the surface. With the increase in the PTA current, Cu particles are gradually dissolved into the alloyed layer and the microstructure of alloyed coating mainly consists of bamboo-like martensite, retained austenite, and dispersed Cu particles. The microhardness of the PTA samples is approximately four times that of the untreated sample. The tribological results exhibit that an abrasive wear at RT and slight abrasive wear with oxidation wear at HT are the dominant wear mechanisms of alloyed coatings. The PTA samples show far superior antifriction properties compared to the untreated and remolten samples at both RT and HT, which can be attributed to the formation of lubricating Cu films and the improvement in microhardness.
Prediction and Experiment of Fracture Behavior in Hot Press Forming of a TA32 Titanium Alloy Rolled Sheet
Authors: Fan Ronglei , Chen Minghe , Wu Yong , Xie Lansheng
Published: November 2018

In aerospace and automotive industries, hot press forming (HPF) technology is widely used for rapid and precise deformation of the complex sheet metal component, where the fracture behavior has always been a focused problem. In this study, the hot tensile test and the Nakazima test were carried out, in order to establish the Misiolek constitutive equation and determine the forming limit strain points at an elevated temperature, respectively. The microstructure evolution during the tensile test was also investigated by optical microscope. In addition, the Marciniak–Kuczynski (M–K) model, considering the Mises, Hill48, and Logan–Hosford yield criteria, was utilized to calculate the theoretical forming limit curve (FLC). Furthermore, the fracture behavior of the TA32 alloy sheet during the HPF process was accurately predicted by inserting the predicted FLC into finite element simulation, and the qualified complex component was obtained by optimizing the shape of the sheet.
Qualitative Identification of the Static Pull-In and Fundamental Frequency of One-Electrode MEMS Resonators
Authors: Han Jianxin , Li Lei , Jin Gang , Ma Wenkui , Feng Jingjing , Jia Haili , Chang Dongmei
Published: November 2018

This paper attempts to qualitatively identify the static pull-in position, pull-in voltage, and fundamental frequency of one-electrode microresonators from a physical perspective. During theoretical derivation, a generalized one-degree-of-freedom (1-DOF) model in nondimensional form derived using the differential quadrature method (DQM) is first introduced and then transformed for frequency normalization. Based on the deduced formulas, the upper and lower bounds of the static pull-in position and pull-in voltage are both deduced through mathematical proof. To distinguish the monotonic and nonmonotonic behavior of the fundamental frequency versus direct current (DC) voltage, a critical condition decided only by cubic stiffness is then determined. For the first time, two extreme static positions, as well as the corresponding fundamental frequencies and DC voltages to identify different frequency behaviors are derived, and their variations versus cubic stiffness are then discussed and verified. During the simulation process, a high-order DQM and COMSOL 2D model are both applied for numerical analyses. Guided by nondimensional results, typical behaviors with specific physical parameters are examined in detail. Results demonstrate that the curve tendencies between all the qualitative results and quantitative numerical simulations in dimensional form agree well with each other, implying the possibility of using 1-DOF model to qualitatively discuss physical parameters effects on the system statics and dynamics.
Alleviating Distortion and Improving the Young’s Modulus in Two-Photon Polymerization Fabrications
Authors: Shin Chow-Shing , Li Tzu-Jui , Lin Chih-Lang
Published: November 2018

Two-photon polymerization enables the extremely high resolution three-dimensional printing of micro-structures. To know the mechanical properties, and better still, to be able to adjust them is of paramount importance to ensuring the proper structural integrity of the printed products. In this work, the Young’s modulus is measured on two-photon polymerized micro-cantilever bars. Optimizing the scanning trajectory of the laser focus points is important in alleviating distortion of the printed bars. By increasing the laser power and decreasing the inter-voxel distances we can double the Young’s modulus. Post-curing with ultraviolet light can approximately quadruple the Young’s modulus. However, the resulting modulus is still only about 0.3% of that of the bulk polymerized material.
Enantioselective Drug Recognition by Drug Transporters
Authors: Uwai Yuichi
Published: November 2018

Drug transporters mediate the absorption, tissue distribution, and excretion of drugs. The cDNAs of P-glycoprotein, multidrug resistance proteins (MRPs/ABCC), breast cancer resistance protein (BCRP/ABCG2), peptide transporters (PEPTs/SLC15), proton-coupled folate transporters (PCFT/SLC46A1), organic anion transporting polypeptides (OATPs/SLCO), organic anion transporters (OATs/SLC22), organic cation transporters (OCTs/SLC22), and multidrug and toxin extrusions (MATEs/SLC47) have been isolated, and their functions have been elucidated. Enantioselectivity has been demonstrated in the pharmacokinetics and efficacy of drugs, and is important for elucidating the relationship with recognition of drugs by drug transporters from a chiral aspect. Enantioselectivity in the transport of drugs by drug transporters and the inhibitory effects of drugs on drug transporters has been summarized in this review.
Separation of Volatile Metabolites from the Leaf-Derived Essential Oil of Piper mollicomum Kunth (Piperaceae) by High-Speed Countercurrent Chromatography
Authors: Marques André M. , Peixoto Ana Clarissa C. , Provance D. William , Kaplan Maria Auxiliadora C.
Published: November 2018

The technique of high-speed countercurrent chromatography was applied to the isolation of compounds in essential oil derived from the leaves of Piper mollicomum species. Plant leaves (200.0 g) were submitted to hydrodistillation in a modified Clevenger apparatus. The resulting crude leaf essential oil was analyzed by gas chromatography with flame ionization detector (GC-FID) and gas chromatography-mass spectrometry (GC-MS) to determine the profile of the components. The purified fractions were composed of monoterpenes and sesquiterpenes such as camphor (85.0 mg at 98.5% purity), (E)-nerolidol (100.0 mg at 92.8% purity), and camphene (150.0 mg at 82.0% purity). A minor component of the essential oil, bornyl acetate (16.2 mg at 91.2% purity) was also isolated in the one-step separation protocol in 2 h. The countercurrent chromatography technique proved to be a fast and efficient method for the separation of volatile metabolites that conserved the solvent while delivering various fractions of high purity.
A Novel Method for the Quantification of White Wine Mannoproteins by a Competitive Indirect Enzyme-Linked Lectin Sorbent Assay (CI-ELLSA)
Authors: Marangon Matteo , Vegro Mara , Vincenzi Simone , Lomolino Giovanna , De Iseppi Alberto , Curioni Andrea
Published: November 2018

Mannoproteins (MPs) are cell wall proteoglycans released in wine by yeast during fermentation and ageing on lees, a procedure used for the production of several wines to enrich them in these components with consequences from both a technological and sensory point of view. Given the significance that wine MPs have for wine quality, winemakers would welcome a simple and accurate method for their quantification, as this would allow them to have a better control of this aspect at different winemaking stages. This study develops and validates a novel, simple and accurate method for MPs quantification in white wines based on a competitive indirect enzyme-linked lectin sorbent assay (CI-ELLSA), using the highly mannosylated yeast invertase as the standard. The method utilizes the lectin concanavalin A (ConA) as the immobilized ligand for MPs, and peroxidase, an enzyme rich in mannose, as the competitor for ConA. After addition of the peroxidase substrate, the intensity of the signal produced by the activity of this enzyme (absorbance at 450 nm) is inversely proportional to the amount of mannosylated proteins in the sample. Results have been validated on several wine styles including still, sparkling and sweet wines.
Preparation of ZnO Nanorods/Graphene Composite Anodes for High-Performance Lithium-Ion Batteries
Authors: Zhang Junfan , Tan Taizhe , Zhao Yan , Liu Ning
Published: November 2018

ZnO is a promising anode material for lithium-ion batteries (LIBs); however, its practical application is hindered primarily by its large volume variation upon lithiation. To overcome this drawback, we synthesized ZnO/graphene composites using the combination of a simple hydrothermal reaction and spray drying. These composites consisted of well-dispersed ZnO nanorods anchored to graphene. The folded three-dimensional graphene spheres provided a high conductivity, high surface area, and abundant defects. LIB with an anode composed of our novel ZnO/graphene material demonstrated a high initial discharge capacity of 1583 mAh g−1 at 200 mA g−1.
Rapid Tartrazine Determination in Large Yellow Croaker with Ag Nanowires Using Surface-Enhanced Raman Spectroscopy
Authors: Song Jia , Zhang Yuanyi , Huang Yiqun , Fan Yuxia , Lai Keqiang
Published: November 2018

In this work, surface-enhanced Raman spectroscopy (SERS) technology coupled with Ag nanowires was shown to be a promising tool in the detection of tartrazine in large yellow croaker for the first time. Ag nanowires with a uniform diameter were fabricated by an efficient and manageable polyol method. The partial least square model was established for the quantitative analysis of tartrazine, which showed a relatively high linear correlation between actual and predicted concentrations of standard tartrazine solutions. An optimal sample preparation method was also selected and used to extract tartrazine from large yellow croaker within 20 min. The lowest concentration detected was 20.38 ng/cm2, which fully meets the requirements of tartrazine testing in aquatic products. This study indicated that SERS technology combined with the as-prepared Ag nanowires could detect tartrazine sensitively and provide an easily operable and time-saving way to monitor tartrazine in large yellow croaker.
Iron Supplementation in Suckling Piglets: An Ostensibly Easy Therapy of Neonatal Iron Deficiency Anemia
Authors: Szudzik Mateusz , Starzyński Rafał R. , Jończy Aneta , Mazgaj Rafał , Lenartowicz Małgorzata , Lipiński Paweł
Published: November 2018

In pigs, iron deficiency anemia (IDA) is the most prevalent deficiency disorder during the early postnatal period, frequently developing into a serious illness. On the other hand, in humans, only low-birth-weight infants, including premature infants, are especially susceptible to developing IDA. In both human and pig neonates, the initial cause of IDA is low birth iron stores. In piglets this shortage of stored iron results mainly from genetic selection over the past few decades for large litter sizes and high birth weights. As a consequence, pregnant sows cannot provide a sufficient amount of iron to the increasing number of developing fetuses. Supplementation with iron is a common practice for the treatment of IDA in piglets. For decades, the preferred procedure for delivering iron supplements during early life stages has been through the intramuscular injection of a large amount of iron dextran. However, this relatively simple therapy, which in general, efficiently corrects IDA, may generate toxic effects, and by inducing hepcidin expression, may decrease bioavailability of supplemental iron. New iron supplements are considered herein with the aim to combine the improvement of hematological status, blunting of hepcidin expression, and minimizing the toxicity of the administered iron. We propose that iron-deficient piglets constitute a convenient animal model for performing pre-clinical studies with iron supplements.
On the Possible Chemical Justification of the Ethnobotanical Use of Hyptis obtusiflora in Amazonian Ecuador
Authors: Luzuriaga-Quichimbo Carmen X. , Blanco-Salas José , Cerón-Martínez Carlos E. , Stanković Milan S. , Ruiz-Téllez Trinidad
Published: November 2018

In rural areas of Latin America, Hyptis infusions are very popular. Hyptis obtusiflora extends from Mexico throughout Central America to Bolivia and Peru. It has added value in Ecuador where it has been used by different ethnic groups. We aimed to learn about the traditional knowledge of ancient Kichwa cultures about this plant, and to contrast this knowledge with the published information organized in occidental databases. We proposed to use traditional knowledge as a source of innovation for social development. Our specific objectives were to catalogue the uses of H. obtusiflora in the community, to prospect on the bibliography on a possible chemical justification for its medicinal use, to propose new products for development, and to give arguments for biodiversity conservation. An ethnobotanical survey was made and a Prisma 2009 Flow Diagram was then followed for scientific validation. We rescued data that are novel contributions for the ethnobotany at the national level. The catalogued main activity of anti-inflammation can be related to the terpene composition and the inhibition of xanthine oxidase. This opens the possibility of researching the extract of this plant as an alternative to allopurinol or uricosuric drugs. This is a concrete example of an argument for biodiversity conservation.
Effects of Cyclic Wetting-Drying Conditions on Elastic Modulus and Compressive Strength of Sandstone and Mudstone
Authors: Huang Shiyuan , Wang Junjie , Qiu Zhenfeng , Kang Kai
Published: November 2018

The influence of water on the mechanical properties of rock is vital for determining the rock stability when subjected to changes of water conditions. In this paper, a series of uniaxial compression tests were conducted to investigate effects of cyclic wetting and drying on the mechanical properties of sandstone and mudstone collected from Chongqing city, China. The results showed that both elastic modulus and uniaxial compressive strength of sandstone and mudstone were reduced by wetting and drying cycles, and that the degradation rate of the two mechanic parameters of mudstone was always larger than sandstone. The parameters, including water adsorption, degradation degree of elastic modulus, degradation degree of uniaxial compressive strength, increase with the increase of the wetting-drying cycles (N). The relationship between these three parameters and the value of N + 1 could be well fitted by logarithmic curves. The average degradation degree was also used to describe the degradation of per time wetting-drying cycles. It is found that the average degradation degree of elastic modulus and uniaxial compressive strength decrease with the increase of wetting-drying cycles. Moreover, the relationships between the mechanical properties and the porosity are presented, which can be fitted by linear curves. In the cyclic wetting-drying process, the elastic modulus and the uniaxial compressive strength decreased with the porosity increasing, and the degradation rates of sandstone mechanic parameters were higher than those of mudstone.
Influence of Thermal Conditions on Particle Properties in Fluidized Bed Layering Granulation
Authors: Neugebauer Christoph , Bück Andreas , Palis Stefan , Mielke Lisa , Tsotsas Evangelos , Kienle Achim
Published: November 2018

Fluidized bed layering granulation is frequently used to formulate particles of high quality. From previous studies, it is well known that the dynamic behavior of the process, as well as the product properties depend on operating parameters. The process is characterized by heat and mass transfer between fluidized particles and the surrounding fluidization medium. To investigate the mutual influence between particle phase and fluidization medium, a dynamic model is introduced. The model comprises two parts: a population balance model to describe the evolution of the particle sizes and a system of ordinary differential equations to account for thermal conditions. For the first time, the dynamic model considers the bidirectional coupling of particles and fluidization medium in fluidized bed layering granulation. By means of simulations, it is shown that the derived model is capable of reproducing the experimental findings.
Estimation of Pore Size Distribution of Amorphous Silica-Based Membrane by the Activation Energies of Gas Permeation
Authors: Ji Guozhao , Gao Xuechao , Smart Simon , Bhatia Suresh K. , Wang Geoff , Hooman Kamel , Diniz da Costa João C.
Published: November 2018

Cobalt oxide silica membranes were prepared and tested to separate small molecular gases, such as He (dk = 2.6 Å) and H2 (dk = 2.89 Å), from other gases with larger kinetic diameters, such as CO2 (dk = 3.47 Å) and Ar (dk = 3.41 Å). In view of the amorphous nature of silica membranes, pore sizes are generally distributed in the ultra-microporous range. However, it is difficult to determine the pore size of silica derived membranes by conventional characterization methods, such as N2 physisorption-desorption or high-resolution electron microscopy. Therefore, this work endeavors to determine the pore size of the membranes based on transport phenomena and computer modelling. This was carried out by using the oscillator model and correlating with experimental results, such as gas permeance (i.e., normalized pressure flux), apparent activation energy for gas permeation. Based on the oscillator model, He and H2 can diffuse through constrictions narrower than their gas kinetic diameters at high temperatures, and this was possibly due to the high kinetic energy promoted by the increase in external temperature. It was interesting to observe changes in transport phenomena for the cobalt oxide doped membranes exposed to H2 at high temperatures up to 500 °C. This was attributed to the reduction of cobalt oxide, and this redox effect gave different apparent activation energy. The reduced membrane showed lower apparent activation energy and higher gas permeance than the oxidized membrane, due to the enlargement of pores. These results together with effective medium theory (EMT) suggest that the pore size distribution is changed and the peak of the distribution is slightly shifted to a larger value. Hence, this work showed for the first time that the oscillator model with EMT is a potential tool to determine the pore size of silica derived membranes from experimental gas permeation data.
Sensing Urban Transportation Events from Multi-Channel Social Signals with the Word2vec Fusion Model
Authors: Lu Hao , Shi Kaize , Zhu Yifan , Lv Yisheng , Niu Zhendong
Published: November 2018

Social sensors perceive the real world through social media and online web services, which have the advantages of low cost and large coverage over traditional physical sensors. In intelligent transportation researches, sensing and analyzing such social signals provide a new path to monitor, control and optimize transportation systems. However, current research is largely focused on using single channel online social signals to extract and sense traffic information. Clearly, sensing and exploiting multi-channel social signals could effectively provide deeper understanding of traffic incidents. In this paper, we utilize cross-platform online data, i.e., Sina Weibo and News, as multi-channel social signals, then we propose a word2vec-based event fusion (WBEF) model for sensing, detecting, representing, linking and fusing urban traffic incidents. Thus, each traffic incident can be comprehensively described from multiple aspects, and finally the whole picture of unban traffic events can be obtained and visualized. The proposed WBEF architecture was trained by about 1.15 million multi-channel online data from Qingdao (a coastal city in China), and the experiments show our method surpasses the baseline model, achieving an 88.1% F1 score in urban traffic incident detection. The model also demonstrates its effectiveness in the open scenario test.
Smartphone-Based Indoor Localization within a 13th Century Historic Building
Authors: Fetzer Toni , Ebner Frank , Bullmann Markus , Deinzer Frank , Grzegorzek Marcin
Published: November 2018

Within this work we present an updated version of our indoor localization system for smartphones. The pedestrian’s position is given by means of recursive state estimation using a particle filter to incorporate different probabilistic sensor models. Our recently presented approximation scheme of the kernel density estimation allows to find an exact estimation of the current position, compared to classical methods like weighted-average. Absolute positioning information is given by a comparison between recent Wi-Fi measurements of nearby access points and signal strength predictions. Instead of using time-consuming approaches like classic fingerprinting or measuring the exact positions of access points, we use an optimization scheme based on a set of reference measurements to estimate a corresponding Wi-Fi model. This work provides three major contributions to the system. The most essential contribution is the novel state transition based on continuous walks along a navigation mesh, modeling only the building’s walkable areas. The localization system is further updated by incorporating a threshold-based activity recognition using barometer and accelerometer readings, allowing for continuous and smooth floor changes. Within the scope of this work, we tackle problems like multimodal densities and sample impoverishment (system gets stuck) by introducing different countermeasures. For the latter, a simplification of our previous solution is presented for the first time, which does not involve any major changes to the particle filter. The goal of this work is to propose a fast to deploy localization solution, that provides reasonable results in a high variety of situations. To stress our system, we have chosen a very challenging test scenario. All experiments were conducted within a 13th century historic building, formerly a convent and today a museum. The system is evaluated using 28 distinct measurement series on four different test walks, up to 310 m length and 10 min duration. It can be shown, that the here presented localization solution is able to provide a small positioning error, even under difficult conditions and faulty measurements. The introduced filtering methods allow for a real fail-safe system, while the optimization scheme enables an on-site setup-time of less then 120 min for the building’s 2500 m2 walkable area.
Performance Analysis of GNSS/INS Loosely Coupled Integration Systems under Spoofing Attacks
Authors: Xu Rui , Ding Mengyu , Qi Ya , Yue Shuai , Liu Jianye
Published: November 2018

The loosely coupled integration of Global Navigation Satellite System (GNSS) and Inertial Navigation System (INS) have been widely used to improve the accuracy, robustness and continuity of navigation services. However, the integration systems possibly affected by spoofing attacks, since integration algorithms without spoofing detection would feed autonomous INSs with incorrect compensations from the spoofed GNSSs. This paper theoretically analyzes and tests the performances of GNSS/INS loosely coupled integration systems with the classical position fusion and position/velocity fusion under typical meaconing (MEAC) and lift-of-aligned (LOA) spoofing attacks. Results show that the compensations of Inertial Measurement Unit (IMU) errors significantly increase under spoofing attacks. The compensations refer to the physical features of IMUs and their unreasonable increments likely result from the spoofing-induced inconsistency of INS and GNSS measurements. Specially, under MEAC attacks, the IMU error compensations in both the position-fusion-based system and position/velocity-fusion-based system increase obviously. Under LOA attacks, the unreasonable compensation increments are found from the position/velocity-fusion-based integration system. Then a detection method based on IMU error compensations is tested and the results show that, for the position/velocity-fusion-based integration system, it can detect both MEAC and LOA attacks with high probability using the IMU error compensations.
HAS4: A Heuristic Adaptive Sink Sensor Set Selection for Underwater AUV-Aid Data Gathering Algorithm
Authors: Wang Xingwang , Wei Debing , Wei Xiaohui , Cui Junhong , Pan Miao
Published: November 2018

In this paper, we target solving the data gathering problem in underwater wireless sensor networks. In many underwater applications, it is not quick to retrieve sensed data, which gives us the opportunity to leverage mobile autonomous underwater vehicles (AUV) as data mules to periodically collect it. For each round of data gathering, the AUV visits part of the sensors, and the communication between AUV and sensor nodes is a novel high-speed magnetic-induction communication system. The rest of the sensors acoustically transmit their sensed data to the AUV-visit sensors. This paper deploys the HAS 4 (Heuristic Adaptive Sink Sensor Set Selection) algorithm to select the AUV-visited sensors for the purpose of energy saving, AUV cost reduction and network lifetime prolonging. By comparing HAS 4 with two benchmark selection methods, experiment results demonstrate that our algorithm can achieve a better performance.