bluuebunny/crossref_metadata_2025 huggingface dataset:
Feasibility and Accuracy of Noninvasive Continuous Arterial Pressure Monitoring during Transcatheter Atrial Fibrillation Ablation
Authors: Di Cori Andrea , Parollo Matteo , Fiorentini Federico , Della Volpe Salvatore , Mazzocchetti Lorenzo , Barletta Valentina , Segreti Luca , Viani Stefano , De Lucia Raffaele , Paperini Luca , Canu Antonio , Grifoni Gino , Soldati Ezio , Bongiorni Maria Grazia , Zucchelli Giulio
Published: March 2023

Introduction: Transcatheter atrial fibrillation (AF) ablation is still carried out with continuous invasive radial arterial blood pressure (IBP) monitoring in many centers. Continuous noninvasive blood pressure (CNBP) measurement using the volume-clamp method is a noninvasive alternative method used in ICU. No data on CNBP reliability are available in the electrophysiology lab during AF ablation, where rhythm variations are common. Background: The objective of the present study was to compare continuous noninvasive arterial pressure measured with the ClearSight device (Edwards Lifesciences, Irvine, CA, USA) with invasive radial artery pressure used as the reference method during AF ablation. Methods: We prospectively enrolled 55 consecutive patients (age 62 ± 11 years, 80% male) undergoing transcatheter AF ablation (62% paroxysmal, 38% persistent) at our center. Standard of care IBP monitoring via a radial cannula and a contralateral noninvasive finger volume-clamp CNBP measurement device were positioned simultaneously in all patients for the entire procedure. Bland-Altman analysis was used to analyze the agreement between the two techniques. Results: A total of 1219 paired measurements for systolic, diastolic, and mean arterial pressure were obtained in 55 subjects, with a mean (SD) of 22 (9) measurements per patient. The mean bias (SD) was −12.97 (13.89) mmHg for systolic pressure (level of agreement −14.24–40.20; correlation coefficient 0.84), −1.85 (8.52) mmHg for diastolic pressure (level of agreement −18.54–14.84; correlation coefficient 0.77) and 2.31 (8.75) mmHg for mean pressure (level of agreement −14.84–19.46; correlation coefficient 0.85). Conclusion: In patients undergoing AF ablation, CNBP monitoring with the ClearSight device showed acceptable agreement with IBP monitoring. Larger studies are needed to confirm the potential clinical implications of continuous noninvasive BP monitoring during AF ablation.
Femoral Anteversion in Total Hip Arthroplasty: Retrospective Comparison of Short- and Straight-Stem Models Using CT Scans
Authors: Klim Sebastian Martin , Reinbacher Patrick , Smolle Maria Anna , Hecker Andrzej , Maier Michael , Friesenbichler Joerg , Leithner Andreas , Leitner Lukas , Draschl Alexander , Lewis Jan , Brunnader Kevin , Maurer-Ertl Werner
Published: March 2023

Data on reconstruction of the femoral anteversion (FA) and the center of rotation after total hip arthroplasty (THA) are rare. We aimed to answer whether a short-stem fixation enables improved anatomical reconstruction of the FA compared to a straight-stem. Methods: One hundred and thirty patients who underwent short- (n = 89, group A, prospective) or straight-stem THA (n = 41, group B, retrospective) were included. CT scans of the hip, knee, and ankle were performed pre- and postoperatively in group A and in group B during the last follow-up. Femoral torsion was determined using three-dimensional models. Results: The mean preoperative FA was 22.4° ± 11.0°, and the mean postoperative FA was 23.4° ± 10.1°. The relative difference was −0.8° ± 8°, and the absolute difference was 6.4° ± 4.9°. Gender analysis revealed significant differences in preoperative FA between female (f) and male (m) patients (28.1° ± 11.2° (f) vs. 18.4° ± 8.3° (m); p > 0.001) as well as in postoperative FA (26.7° ± 23.5° (f) vs. 21.0° ± 9.7° (m); p < 0.007) in group A. Postoperative FA was higher in group A (mean 6.8°; 23.9° ± 10.1° (f) vs. 16.6° ± 8.6° (m); p < 0.001). Conclusions: The study’s findings suggest that short-stem THA leads to improved anatomical FA reconstruction; however, a substantial postoperative gender-related FA difference was detectable, which may warrant consideration by surgeons when determining the final stem anteversion. It should be noted that the impact of the postoperative gender-related FA difference on clinical outcomes is not entirely clear, and further research is warranted to elucidate this relationship.
Impact of COVID-19 Confinement on Quality of Life of Patients with Age-Related Macular Degeneration: A Two-Wave Panel Study
Authors: Sanabria María R. , Calles-Monar Paola S. , Alonso-Tarancón Ana M. , Coco-Martín Rosa M. , Mayo-Iscar Agustín
Published: March 2023

Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries. Intravitreal injections of antiangiogenic agents (anti-VEGF) can stop vision loss in the neovascular form of the disease (nAMD). The aim of this study was to assess the general health-related quality of life (HRQoL) in a cohort of patients with nAMD treated with intravitreal anti-VEGF injections and to detesrmine to what extent their HRQoL was affected by COVID-19. This was an observational, analytical, and longitudinal study performed with a two-wave panel survey. Clinical outcomes, HRQoL, and tangible support were evaluated. In the final survey, changes in living conditions and medical visits due to the COVID-19 pandemic were also examined. Of the 102 patients initially interviewed in the before-COVID survey, 24 were lost after 30 months of follow-up. In the initial assessment, the mean health index was 0.73 ± 0.2. The EQ VAS score worsened at the final survey (p = 0.048). Patients needing treatment in both eyes (p = 0.007) and with lower levels of bilateral visual acuity (p = 0.018) reported an increase in social support at the final survey. In conclusion, patients perceived a worsening in HRQoL after confinement. However, patients enjoyed good social support that improved in the after-COVID survey.
Comparison of the Persistence of Anti-TNF Agents and Ustekinumab in Patients with Crohn’s Disease: A Study Based on the Korean National Database
Authors: Seo Gi Hyeon , Jung Sung Hoon
Published: March 2023

Background: Biologics play an important role in the treatment of moderate to severe Crohn’s disease (CD). Ustekinumab was approved for such patients in the Republic of Korea on 1 December 2018. Therefore, we need to compare the efficacy of ustekinumab and anti-TNF inhibitors. Methods: We compared one-year persistence rates between anti-TNF inhibitors and ustekinumab in moderate-to-severe CD patients using Korean National Health Insurance Service data from 1 December 2016 to 30 November 2021. We also analysed the risk factors for the non-persistence of biologics. Results: The one-year persistence rates with index therapy in bio-naïve and bio-experienced patients were 87.7% and 69.7% for infliximab (p < 0.001), 85.1% and 72.8% for adalimumab (p < 0.001), and 92.1% and 89.8% for ustekinumab (p = 0.333), respectively. The risk factors for non-persistence were older age, non-use of an immune modulator, and previous biologic exposure in both the infliximab and adalimumab groups. The one-year persistence rate of ustekinumab was higher than that of anti-TNF inhibitors in bio-naïve patients (hazard ratio [HR] 0.53; 95% confidence interval [CI] 0.35–0.81; p = 0.003) and bio-experienced patients (HR 0.32; 95% CI 0.22–0.45; p < 0.001). Conclusions: Ustekinumab was superior in bio-naïve CD patients compared to anti-TNF inhibitors. However, the follow-up time was relatively short; further studies should continuously collect and analyse data.
Measurement Efficiency of a Teacher Rating Scale to Screen for Students at Risk for Social, Emotional, and Behavioral Problems
Authors: Casale Gino , Herzog Moritz , Volpe Robert J.
Published: March 2023

Teacher rating scales are broadly used for psycho-educational assessment in schools. In particular, they play an important role in screening students for social, emotional, and behavioral problems. In order to optimize the efficiency of these measures, it is important to minimize the number of items comprising them while maintaining sound psychometric characteristics. This study examines the measurement efficiency of a teacher rating scale for student social, emotional, and behavioral risk. The goal was to shorten an existing behavior screening tool. A total of 139 classroom teachers and 2566 students from Grades 1–6 (Mage = 8.96 years, SD = 1.61) participated in the study. In sum, 35 items assessing internalizing and externalizing behavior problems were analyzed applying the item response theory (generalized partial credit model). The results show that social, emotional, and behavioral risks can be captured with a total of 12 items. This reduction of almost 66% of the initial item pool would take teachers about 90 s to fill out for one student. Thus, the rating scale can be used by teachers in an efficient yet psychometrically sound manner.
Material Cost Minimization Method of the Ship Structure Considering Material Selection
Authors: Putra Gerry Liston , Kitamura Mitsuru
Published: March 2023

Numerous studies have been conducted to minimize material costs and improve efficiency, one of which involves using the genetic algorithm (GA) for material selection. Although the GA provides the best solution, it is computationally intensive. To mitigate this issue, a simple method was proposed. The stiffened plate, a primary component of ship structure, was chosen as the optimization model for this study, with the objective of minimizing material costs using the proposed simple method. Two design variables, plate thickness (t) and plate material type (m), were selected with specific constraints. The simple method was used to determine the appropriate plate material types to reduce material costs. Additionally, size optimization was conducted using stress equations to produce the optimal thickness. The results showed that this method significantly reduced the computational time and material cost of the ship structure.
The Combined Bearing Capacities of Anchor Chain Segment by Considering Its Actual Geometry and Roughness
Authors: Zhang Yang , Zhao Liang , Wang Dong
Published: March 2023

The soil resistances along the embedded ground chain affect the pull-out capacity of anchor as they determine the magnitude and direction of tension at the padeye. To facilitate analyses, the chain was usually simplified as a cylindrical line. The chain segment with actual geometry, buried deeply in clayey soil, is studied using a large deformation finite element approach to overcome severe distortion of soil elements around the chain. The uniaxial resistances obtained by the large deformation analyses are verified by comparison with the existing model tests and simplified solutions, followed by presentation of the yield envelope against combined loading. Both the probe test and swipe test are used to form the yield envelopes, and their results have good consistency. The influence of roughness of chain–soil interface on the soil resistances is quantified as well. It is found that the envelope of the chain segment with actual geometry is smaller than that against the simplified cylindrical shape; therefore, the most convenient design may not be the safest option.
Non-Hydrostatic Numerical Model of Bragg Resonance on Periodically Submerged Breakwater
Authors: Oginni Tolulope Emmanuel , Zhao Xizeng
Published: March 2023

The Bragg resonance (BR) of a reflection coefficient resulting from the propagation of monochronic waves over periodically submerged breakwater was studied using the non-hydrostatic numerical model SWASH (Simulating WAves till SHore). Bragg resonance occurs when the incident wavelength is approximately twice the structural length of a periodic structural breakwater according to Bragg’s law and conditions. This study aimed to investigate the dynamics of Bragg resonance at water depths of 0.2, 0.3, and 0.4 m as the number of periodically submerged breakwater and their wavelengths changed. Specifically, this study focused on the Bragg resonance point of occurrence at a ratio of two structural wavelengths to the incoming wavelengths (2S/L). Regular waves were propagated over two periodically submerged breakwaters, with increasing structural wavelengths from 1 to 2 m at 0.2 m intervals. The results showed that Bragg resonances rapidly increase in value as the water depth decreases, but do not shift in their point of occurrence as the number of periodically submerged breakwaters increases. However, the Bragg resonance shifts leftward in 2S/L as the structural wavelength increases, with a slight increase in value at shallower water depths. More incident wave energy is reflected when the number of periodically submerged breakwater increases compared with when the structural wavelength of the periodically submerged breakwater increases. The differences in the Bragg resonance values are associated with the changes in the number of periodically submerged breakwater. Additionally, the shift in the point of occurrence was influenced by both water depth and structural length. This causes the Resulted Bragg resonance to deviate from the Expected Bragg resonance, which could be the reason why Bragg resonance does not mainly occur at 2S/L=1, as stated by Bragg’s law.
Study of the Optimal Grid Resolution and Effect of Wave–Wave Interaction during Simulation of Extreme Waves Induced by Three Ensuing Typhoons
Authors: Hsiao Shih-Chun , Wu Han-Lun , Chen Wei-Bo
Published: March 2023

Three typhoons, Meranti, Malakas, and Megi, occurred successively in eastern Taiwanese waters in September 2016, causing extreme waves (significant wave height > 10.0 m), and these events were selected to investigate the effect of model grid resolution and wave–wave interaction on simulating typhoon-driven waves. The WAVEWATCH III (WW3) model, with 0.50 deg, 0.25 deg, 0.20 deg, 0.10 deg, and 0.05 deg grid resolutions, and two reanalysis wind fields were adopted to simulate ocean waves during these three typhoons. The results indicated that the exertion of the Climate Forecast System version 2 (CFSv2) winds over the WW3 model with 0.10 deg grid resolution yielded optimum simulations of typhoon waves in a compromise between accuracy and elapsed time. In the present study, the WW3 model modeled nonlinear wave–wave interactions using discrete interaction approximation (DIA). The numerical experiments revealed that the underestimations of typhoon waves were significant when the WW3 model excluded nonlinear wave–wave interactions, especially when employing a higher grid resolution. This study also found that the WW3 model is superior to the Wind Wave Model III (WWM-III) using the CFSv2 winds because the WWM-III tended to overestimate the extreme waves in all three of these eastern Taiwan typhoon events that occurred in September 2016.
Intraoperative Hypertension Is Associated with Postoperative Acute Kidney Injury after Laparoscopic Surgery
Authors: Tang Yongzhong , Li Bo , Ouyang Wen , Jiang Guiping , Tang Hongjia , Liu Xing
Published: March 2023

Background: It is well demonstrated that intraoperative blood pressure is associated with postoperative acute kidney injury (AKI); however, the association between severity and duration of abnormal intraoperative blood pressure (BP) with AKI in patients undergoing laparoscopic surgery remains unknown. Methods: This retrospective cohort study included 12,414 patients aged ≥ 18 years who underwent a single elective laparoscopic abdominal surgery during hospitalization between October 2011 and April 2017. Multivariate stepwise logistic regressions were applied to determine the correlation between the severity and duration of intraoperative mean arterial pressure (MAP, (systolic BP + 2 × diastolic BP)/3), acute intraoperative hypertension (IOTH) and postoperative AKI, in different periods of surgery. Results: A total of 482 hospitalized patients (3.9%) developed surgery-related AKI. Compared with those without IOTH or with preoperative mean MAP (80–85 mmHg), acute elevated IOTH (odds ratio, OR, 1.4, 95% CI, 1.1 to 1.7), mean MAP 95–100 mmHg (OR, 1.8; 95% CI, 1.3 to 2.7), MAP 100–105 mmHg (OR, 2.4; 95% CI, 1.6 to 3.8), and more than 105 mmHg (OR, 1.9; 95% CI, 1.1 to 3.3) were independent of other risk factors in a diverse cohort undergoing laparoscopic surgery. In addition, the risk of postoperative AKI appeared to result from long exposure (≥20 min) to IOTH (OR, 1.9; 95% CI, 1.5 to 2.5) and MAP ≥ 115 mmHg (OR, 2.2; 95% CI, 1.6 to 3.0). Intraoperative hypotension was not found to be associated with AKI in laparoscopic surgery patients. Conclusions: Postoperative AKI correlates positively with intraoperative hypertension in patients undergoing laparoscopic surgery. These findings provide an intraoperative evaluation criterion to predict the occurrence of postoperative AKI.
Assessing the Impact of Transcutaneous Maxillary Distraction Osteogenesis on Pharyngeal Airway Volume in Children with Cleft Lip and Palate: A 3D Evaluation Study
Authors: Chan Chia-Hsuan , Tsai Chi-Yu , Lai Jui-Pin , Lin Shiu-Shiung , Chang Yu-Jen
Published: March 2023

Cleft lip and cleft palate (CLCP) patients often have a retrusive maxilla and a severe skeletal Class III malocclusion, which can result in velopharyngeal insufficiency (VPI). The aim of this study was to evaluate the changes in the volume of the 3D airway in CLCP children after maxilla distraction using the transcutaneous maxillary distraction osteogenesis (TMDO) method. 15 children with bilateral or unilateral CLCP were included in the study. 3D CBCT images were taken before and after distraction and were segmented and reconstructed to create a 3D airway model. The airway was divided into three regions: the upper, oropharyngeal, and hypopharyngeal airway. Pearson correlation tests were used to assess correlations between volume changes and corresponding skeletal and dental landmark movements (Point N, ANS, A, B, Pog, U1, and L1). The results showed that the ANS point advanced 9.85 ± 3.60 mm, and the A point advanced 14.22 ± 4.57 mm. The total airway volume change increased by 2535.06 ± 2791.80 mm3. However, there was no significant correlation between the A/ANS/U1 and the three different airway regions. Only B/Pog/L1 showed a positive correlation with these airway regions, with a high correlation between B/Pog/L1 and the hypopharyngeal airway region. TMDO can result in greater anterior advancement of the maxilla and an increase in airway volume, but the changes in bony landmarks did not show a strong positive correlation with the increase in airway volume as expected. Further investigation is needed to analyze the influence of surrounding soft tissue on the changes in airway volume.
The Association of Intravitreal Injections of Different Anti-Vascular Endothelial Growth Factor with Systemic Outcomes in Diabetic Patients
Authors: Kang Eugene Yu-Chuan , Lin Tzu-Yi , Garg Sunir J. , Wang Nan-Kai , Chen Lee-Jen , Huang Pei-Wei , Chan Ming-Jen , Chen Kuan-Jen , Wu Wei-Chi , Lai Chi-Chun , Hwang Yih-Shiou
Published: March 2023

This retrospective cohort study aimed to assess the systemic effects of three commonly available anti-vascular endothelial growth factor intravitreal injections in patients with diabetes, using data taken from a multi-institutional database in Taiwan. Patient data were sourced from the multi-institutional Chang Gung Research Database. Participants were divided into groups based on treatment with bevacizumab, ranibizumab, or aflibercept. Baseline characteristics were matched among the groups by the inverse probability of treatment weighting. The incidence rate of outcome events was calculated as the number of events divided by 100 person-years of follow-up. The cumulative incidence function was used to estimate the incidence rate of the outcome events among groups. The incidence of ischemic stroke was higher in the ranibizumab group than the bevacizumab and aflibercept groups (1.65, 0.92, and 0.61 per 100 person-years, respectively). The incidence of major adverse lower-limb events was higher in the bevacizumab group (2.95), followed by ranibizumab (2.00) and aflibercept (0.74). Major bleeding was relatively higher in bevacizumab (12.1) compared to ranibizumab (4.3) and aflibercept (3.8). All-cause death was higher for both bevacizumab (3.26) and aflibercept (2.61) when compared to ranibizumab (0.55), and all-cause admission was found to be highest with bevacizumab (58.6), followed by aflibercept (30.2), and ranibizumab (27.6). The bevacizumab group demonstrated a greater decrease in glycated hemoglobin compared to the baseline level (−0.33%). However, a few differences in the clinical condition between the groups were still observed after matching. In conclusion, this study suggests that different anti-vascular endothelial growth factor agents may be associated with various and differing systemic adverse events. The differences might also be attributed to differences in patient characteristics and clinical status.
Generative Adversarial Networks Can Create High Quality Artificial Prostate Cancer Magnetic Resonance Images
Authors: Xu Isaac R. L. , Van Booven Derek J. , Goberdhan Sankalp , Breto Adrian , Porto Joao , Alhusseini Mohammad , Algohary Ahmad , Stoyanova Radka , Punnen Sanoj , Mahne Anton , Arora Himanshu
Published: March 2023

The recent integration of open-source data with machine learning models, especially in the medical field, has opened new doors to studying disease progression and/or regression. However, the ability to use medical data for machine learning approaches is limited by the specificity of data for a particular medical condition. In this context, the most recent technologies, like generative adversarial networks (GANs), are being looked upon as a potential way to generate high-quality synthetic data that preserve the clinical variability of a condition. However, despite some success, GAN model usage remains largely minimal when depicting the heterogeneity of a disease such as prostate cancer. Previous studies from our group members have focused on automating the quantitative multi-parametric magnetic resonance imaging (mpMRI) using habitat risk scoring (HRS) maps on the prostate cancer patients in the BLaStM trial. In the current study, we aimed to use the images from the BLaStM trial and other sources to train the GAN models, generate synthetic images, and validate their quality. In this context, we used T2-weighted prostate MRI images as training data for Single Natural Image GANs (SinGANs) to make a generative model. A deep learning semantic segmentation pipeline trained the model to segment the prostate boundary on 2D MRI slices. Synthetic images with a high-level segmentation boundary of the prostate were filtered and used in the quality control assessment by participating scientists with varying degrees of experience (more than ten years, one year, or no experience) to work with MRI images. Results showed that the most experienced participating group correctly identified conventional vs. synthetic images with 67% accuracy, the group with one year of experience correctly identified the images with 58% accuracy, and the group with no prior experience reached 50% accuracy. Nearly half (47%) of the synthetic images were mistakenly evaluated as conventional. Interestingly, in a blinded quality assessment, a board-certified radiologist did not significantly differentiate between conventional and synthetic images in the context of the mean quality of synthetic and conventional images. Furthermore, to validate the usability of the generated synthetic images from prostate cancer MRIs, we subjected these to anomaly detection along with the original images. Importantly, the success rate of anomaly detection for quality control-approved synthetic data in phase one corresponded to that of the conventional images. In sum, this study shows promise that high-quality synthetic images from MRIs can be generated using GANs. Such an AI model may contribute significantly to various clinical applications which involve supervised machine-learning approaches.
The Flipping-Wedge Osteotomy: How 3D Virtual Surgical Planning (VSP) Suggested a Simple and Promising Type of Osteotomy in Pediatric Post-Traumatic Forearm Deformity
Authors: Depaoli Alessandro , Menozzi Grazia Chiara , Di Gennaro Giovanni Luigi , Ramella Marco , Alessandri Giulia , Frizziero Leonardo , Liverani Alfredo , Martinelli Daniela , Rocca Gino , Trisolino Giovanni
Published: March 2023

(1) Background: The application of computer-aided planning in the surgical treatment of post-traumatic forearm deformities has been increasingly widening the range of techniques over the last two decades. We present the “flipping-wedge osteotomy”, a promising geometrical approach to correct uniapical deformities defined during our experience with virtual surgical planning (VSP); (2) Methods: a case of post-traumatic distal radius deformity (magnitude 43°) treated with a flipping-wedge osteotomy in an 11-year-old girl is reported, presenting the planning rationale, its geometrical demonstration, and the outcome of the procedure; (3) Results: surgery achieved correction of both the angular and rotational deformities with a neutral ulnar variance; (4) Conclusions: flipping-wedge osteotomy may be a viable option to achieve correction in forearm deformities, and it deserves further clinical investigation.
High-Throughput Sequencing Reveals That Rotundine Inhibits Colorectal Cancer by Regulating Prognosis-Related Genes
Authors: Huang Lingyu , Zou Tongxiang , Liang Wenken , Mo Chune , Wei Jianfen , Deng Yecheng , Ou Minglin
Published: March 2023

Background: Rotundine is an herbal medicine with anti-cancer effects. However, little is known about the anti-cancer effect of rotundine on colorectal cancer. Therefore, our study aimed to investigate the specific molecular mechanism of rotundine inhibition of colorectal cancer. Methods: MTT and cell scratch assay were performed to investigate the effects of rotundine on the viability, migration, and invasion ability of SW480 cells. Changes in cell apoptosis were analyzed by flow cytometry. DEGs were detected by high-throughput sequencing after the action of rotundine on SW480 cells, and the DEGs were subjected to function enrichment analysis. Bioinformatics analyses were performed to screen out prognosis-related DEGs of COAD. Followed by enrichment analysis of prognosis-related DEGs. Furthermore, prognostic models were constructed, including ROC analysis, risk curve analysis, PCA and t-SNE, Nomo analysis, and Kaplan–Meier prognostic analysis. Results: In this study, we showed that rotundine concentrations of 50 μM, 100 μM, 150 μM, and 200 μM inhibited the proliferation, migration, and invasion of SW480 cells in a time- and concentration-dependent manner. Rotundine does not induce SW480 cell apoptosis. Compared to the control group, high-throughput results showed that there were 385 DEGs in the SW480 group. And DEGs were associated with the Hippo signaling pathway. In addition, 16 of the DEGs were significantly associated with poorer prognosis in COAD, with MEF2B, CCDC187, PSD2, RGS16, PLXDC1, HELB, ASIC3, PLCH2, IGF2BP3, CLHC1, DNHD1, SACS, H1-4, ANKRD36, and ZNF117 being highly expressed in COAD and ARV1 being lowly expressed. Prognosis-related DEGs were mainly enriched in cancer-related pathways and biological functions, such as inositol phosphate metabolism, enterobactin transmembrane transporter activity, and enterobactin transport. Prognostic modeling also showed that these 16 DEGs could be used as predictors of overall survival prognosis in COAD patients. Conclusions: Rotundine inhibits the development and progression of colorectal cancer by regulating the expression of these prognosis-related genes. Our findings could further provide new directions for the treatment of colorectal cancer.
Clinical Characteristics of Minimal Lumbar Disc Herniation and Efficacy of Percutaneous Endoscopic Lumbar Discectomy via Transforaminal Approach: A Retrospective Study
Authors: Chen Feifei , Yang Guihe , Wang Jinjin , Ge Zhongpeng , Wang Heran , Guo Yifei , Yang Heng , Jing Xingzhi , Liu Xiaoyang , Cui Xingang
Published: March 2023

Objective: To define the characteristics of Mini LDH, develop new diagnostic references and examine the clinical efficacy of percutaneous endoscopic lumbar discectomy via a transforaminal approach (TF-PELD) for it. Methods: A total of 72 patients who underwent TF-PELD with Mini LDH from September 2019 to October 2022 were enrolled in this retrospective study. The patients’ basic information, symptoms, number of outpatient visits, duration of conservative treatment, physical examination findings and so on were obtained from the medical records. Clinical effects of TF-PELD for Mini LDH were assessed by means of the following: the Visual Analog Scale (VAS) for low back pain (LBP) and leg pain, Oswestry Disability Index (ODI) for functional status assessment and Modified Mac Nab criteria for patient satisfaction. Results: Mini LDH have specific clinical characteristics and imaging features. All included patients achieved obvious pain relief after TF-PELD surgery. Pain scores were repeated at postoperative day 1 and 1, 3, 6, 12 and 24 months later. Results were statistically analyzed. The average VAS-Back, VAS-Leg and ODI scores were all significantly reduced at the first postoperative day and gradually decreased with the follow-up time continuing. In total, 66 out of 72 patients received an excellent or good recovery and no poor result was reported according to the Modified Mac Nab criteria. Conclusions: Mini LDH is a type of LDH with special characteristics and in need of correct diagnosis and active treatment in clinical work. TF-PELD was also found to be an effective procedure for the treatment of Mini LDH.
Challenges of E-Learning: Behavioral Intention of Academicians to Use E-Learning during COVID-19 Crisis
Authors: Khan Mohammad Jamal , Reddy Lingala Kalyan Viswanath , Khan Javed , Narapureddy Bayapa Reddy , Vaddamanu Sunil Kumar , Alhamoudi Fahad Hussain , Vyas Rajesh , Gurumurthy Vishwanath , Altijani Abdelrhman Ahmed Galaleldin , Chaturvedi Saurabh
Published: March 2023

The COVID-19 crisis demanded that all educational activities should be performed virtually to follow social distancing guidelines. Therefore, there was a need to perform a research study to assess the effects of external factors on the perceived usefulness, ease of use of e-learning, and the further effect of these perceptions on attitude and intent to use e-learning by using the technology acceptance model (TAM) among academicians at higher education institutions in the Kingdom of Saudi Arabia. Methods: A cross-sectional study was conducted, and data were collected from 263 academicians across Saudi Arabia through an online survey questionnaire using a non-probability purposive sampling technique and analyzed and tested using the SPSS and Smart PLS software. Results: This study found that self-efficacy was positively associated with perceived usefulness at β = 0.143 and p < 0.05, but it had no association with perceived ease of use at β = 0.057 at p > 0.05. System accessibility had a significant and positive relationship with perceived usefulness and perceived ease of use at β = 0.283, β = 0.247, and p < 0.01, respectively. Self-efficacy had a positive effect on perceived usefulness, whereas the subjective norm had no relationship with perceived usefulness and perceived ease of use at β = −0.065 and β = −0.012 at p > 0.05, respectively. Perceived ease of use and perceived usefulness were positively related to attitude towards use, which has a significant influence on intention to use e-learning. Conclusion: Perceived ease of application is the most significant factor (β = 0.556) in developing the attitude among academicians to practice e-learning, followed by perceived usefulness (β = 0.262). Moreover, it can be concluded that system accessibility has a stronger influence on developing perception among academicians about the expediency and ease of application of e-learning than self-efficacy.
Synchrony 2022: Epilepsy and Seizures in Autism Spectrum Disorder Roundtable
Authors: Frye Richard E. , Nanda Heer , Pleasure Samuel J. , Casanova Manuel F. , Boles Richard G. , Lewine Jeffrey , Gaitanis John , Adams James B.
Published: March 2023

The BRAIN Foundation (Pleasanton, CA, USA) hosted Synchrony 2022, a translational medicine conference focused on research into treatments for individuals with neurodevelopmental disorders (NDD), including those with autism spectrum disorders (ASD) [...]
Impact of Community-Based Governance Mechanisms on Transaction Intention on a Second-Hand Trading Platform
Authors: Liu Yuru , Wan Yan , Kang Jun
Published: March 2023

Second-hand trading platforms are helpful to the recycling of resources. It is important to accelerate the construction of second-hand trading platforms and improve people’s willingness to buy second-hand goods. However, due to the uncertainty of second-hand goods, it is difficult to establish the trust between users and complete second-hand transactions. Nowadays, more and more platforms use community-based governance mechanisms to promote relationships between users. Taking the second-hand trading platform Xianyu as an example, this study explores the influence of three specific community-based mechanisms (interest group, feedback mechanism and dispute resolution mechanism) on trust and transaction intention from three dimensions of relational governance. This study compares the different effect between consumers and prosumers. Based on 721 valid questionnaires, a structural equation model was used to analyze the data. The results show that interest group, feedback mechanism and dispute resolution mechanism all have significant positive effects on trust in sellers and platforms. In addition, the impact of a dispute resolution mechanism on trust in sellers and platforms is higher for prosumers than for consumers. This study extends the previous research on community-based governance, contributes to the design of second-hand trading platforms and promotes more users to participate in recycling economy.
Filling the Gaps in Biophysical Knowledge of Urban Ecosystems: Flooding Mitigation and Stormwater Retention
Authors: Salata Stefano
Published: March 2023

Urban flooding is one of the most recognized problems cities must tackle in the coming decades due to climate change conditions. Nevertheless, the empirical knowledge of the biophysical capacity of cities to absorb, store or retain and release water after rainfall events is limited, partly due to the gaps that modeling has in terms of representing the complexity of urban systems. This limit, in turn, affects the decision-making process related to the system’s adaptation. This work aims to integrate two types of alternative spatial ecosystem modeling and see how results can be combined, evaluated and used in view of a more holistic comprehension of flooding phenomena while reaching a deeper understanding of the vulnerability to multiple types of rain events: flash floods versus annual precipitation. The results of the two modeling sessions will be analyzed and compared. They will be further used to gather a greater understanding of the biophysical complexity of Izmir’s Metropolitan City in Turkey: one of the most dynamic but climatically threatened urban areas in the Mediterranean basin. The findings confirm the extent to which empirical knowledge of the urban system is partial and uncertain, thus requiring continuous progress through ecosystem modeling to support an evolutive interpretation of biophysical performances based on trial and error.
Disaster Risk Regionalization and Prediction of Corn Thrips Combined with Cloud Model: A Case Study of Shandong Province, China
Authors: Zuo Yanan , Jin Fengxiang , Ji Min , Li Zhenjin , Yang Jiutao
Published: March 2023

Corn thrips do serious harm to the yield and quality of corn. In this paper, the Shandong Province of China was taken as the study area. Based on the data of the occurrence of corn thrips in Shandong Province, a risk regionalization model was established by using eight indicators under four categories of hazard, sensitivity, vulnerability and the disaster prevention and mitigation capacity of diseases and pests on a monthly time scale. Firstly, the cloud model was introduced to determine the weight of each indicator, and then the risk regionalization of the corn thrips disaster in Shandong Province was carried out using the weighted percentage method, the weighted comprehensive evaluation method and the natural disaster risk index method. Finally, combined with the collected data, the disaster prediction of corn thrip occurrence degree was realized based on multiple linear regression, genetic algorithm optimized back-propagation neural network and genetic algorithm optimized support vector machine methods. The results show that: (1) the risk of Corn thrips disaster is mainly concentrated in the central and western parts of Shandong Province. Heze City is a high-risk area. Liaocheng City, Dezhou City, Jinan City and Weifang City are relatively high-risk areas. (2) By comparing the prediction accuracy of the three models, it was determined that the genetic algorithm optimized support vector machine model has the best effect, with an average accuracy of 79.984%, which is 7.013% and 22.745% higher than that of the multiple linear regression and genetic algorithm optimized back-propagation neural network methods, respectively. The results of this study can provide a scientific basis for fine prevention of corn thrips in Shandong Province.
“Alleged Disabilities”: The Evolving Tactics of Child Protection in a Disability Rights Environment
Authors: Sigurjónsdóttir Hanna Björg , Rice James Gordon
Published: March 2023

This contribution reports on a child protection case concerning the removal of a child from the custody of a parent with intellectual and developmental disabilities (IDD) in Iceland. Employing a mix of document analysis and interviewing, the results demonstrated two key themes forming the analysis: One is the aura of professionalism. A careful examination of the working methods reveals a continuation of the poor practices typical of the past, despite the claims made that specialised support for persons with disabilities has been tried and was not successful. The second analytical theme is alleged disabilities. This case provided evidence of a previously unseen tactic, to the best of our knowledge, by which a parent’s disability status was called into question. The argument offered herein is that this was pursued to sidestep the protections afforded to disabled parents under Icelandic law in recent years. We conclude by arguing that the combination of a heighted awareness of these legal protections and a greater scrutiny as to how these cases are worked appears to have led to a series of evolving tactics that are employed against disabled parents in an enhanced disability rights environment.
Policy and Legal Implications for Working with Unaccompanied Immigrant Children in Foster Care in the United States
Authors: Evans Kerri
Published: March 2023

Unaccompanied immigrant children arrive in the US having fled deteriorating conditions and human rights violations in their home countries. Despite the large numbers of unaccompanied children, there is a lack of research on outcomes for unaccompanied children in the US and particularly for those in the Office of Refugee Resettlement’s (ORR) Long Term Foster Care (LTFC) program. This manuscript begins with a review of the existing laws that influence unaccompanied children (UC) served through the ORR’s LTFC program and a review of the current research on UC in foster care in the US. Notably, this manuscript also visualizes the numbers of UC that have arrived in the US since the early 2000s. These are used to provide a synthesis of recommendations for policy and practice with unaccompanied children.
Do Medical Universities Students Use Cognitive Enhancers while Learning?—Conclusions from the Study in Poland
Authors: Merwid-Ląd Anna , Passon Michał , Drymluch Paweł , Głuszyński Maciej , Szeląg Adam , Matuszewska Agnieszka
Published: March 2023

Background: Stress and everyday problems may impact memory and cognition. Therefore, many people use cognitive enhancers (CEs), sold for prescription, as over-the-counter drugs, or dietary supplements, believing they may help with everyday functioning. Our study was designed to answer whether taking CEs is common among Medical University students and to identify which substances are mainly used. Methods and Results: An anonymous online questionnaire was answered by 479 students of Medical (88%) and Dentistry (12%) Faculties in Poland. Women constituted the majority of respondents (63%). CEs were used by 53% of respondents, with the most frequent being caffeine, ginseng, nicotine, theanine, ginkgo, and lecithin. Some persons used CEs that are available only with a prescription. The most important reasons for the use of CEs were to increase arousal and improve concentration (mentioned by 81% and 73%, respectively). Over 65% of students experienced some undesired/adverse effects after taking CEs, with tachycardia being the most common, followed by sleep disturbances (reported by 51% and 40%, respectively). Conclusions: More than half of the respondents from the Medical and Dentistry Faculties reported using CEs, despite their unproven efficacy and not-well-established safety. This raises significant concern about the knowledge of young persons regarding CEs and should encourage universities to undertake educational actions.
Apocynin Ameliorates Monosodium Glutamate Induced Testis Damage by Impaired Blood-Testis Barrier and Oxidative Stress Parameters
Authors: Acikel-Elmas Merve , Algilani Salva Asma , Sahin Begum , Bingol Ozakpinar Ozlem , Gecim Mert , Koroglu Kutay , Arbak Serap
Published: March 2023

Background: the aim of this study was to investigate the effects of apocynin (APO) on hormone levels, the blood-testis barrier, and oxidative biomarkers in monosodium glutamate (MSG) induced testicular degeneration. Methods: Sprague Dawley male rats (150–200 g; n = 32) were randomly distributed into four groups: control, APO, MSG, and MSG + APO. MSG and MSG + APO groups were administered MSG (120 mg/kg) for 28 days. Moreover, the APO and MSG + APO groups received APO (25 mg/kg) during the last five days of the experiment. All administrations were via oral gavage. Finally, biochemical analyses were performed based on the determination of testosterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), malondialdehyde (MDA), glutathione (GSH), and superoxide dismutase (SOD), as well as light and transmission electron microscopic examinations, assessment of sperm parameters, ZO-1, occludin, NOX-2, and TUNEL immunohistochemistry were evaluated. Results: MSG increased both the oxidative stress level and apoptosis, decreased cell proliferation, and caused degeneration in testis morphology including in the blood-testis barrier. Administration of apocynin reversed all the deteriorated morphological and biochemical parameters in the MSG + APO group. Conclusions: apocynin is considered to prevent testicular degeneration by maintaining the integrity of the blood-testis barrier with balanced hormone and oxidant/antioxidant levels.
Host–Parasite Coevolution in Primates
Authors: Zinner Dietmar , Paciência Filipa M. D. , Roos Christian
Published: March 2023

Organisms adapt to their environment through evolutionary processes. Environments consist of abiotic factors, but also of other organisms. In many cases, two or more species interact over generations and adapt in a reciprocal way to evolutionary changes in the respective other species. Such coevolutionary processes are found in mutualistic and antagonistic systems, such as predator–prey and host–parasite (including pathogens) relationships. Coevolution often results in an “arms race” between pathogens and hosts and can significantly affect the virulence of pathogens and thus the severity of infectious diseases, a process that we are currently witnessing with SARS-CoV-2. Furthermore, it can lead to co-speciation, resulting in congruent phylogenies of, e.g., the host and parasite. Monkeys and other primates are no exception. They are hosts to a large number of pathogens that have shaped not only the primate immune system but also various ecological and behavioral adaptions. These pathogens can cause severe diseases and most likely also infect multiple primate species, including humans. Here, we briefly review general aspects of the coevolutionary process in its strict sense and highlight the value of cophylogenetic analyses as an indicator for coevolution.
Chlorophyll Meter: A Precision Agricultural Decision-Making Tool for Nutrient Supply in Durum Wheat (Triticum turgidum L.) Cultivation under Drought Conditions
Authors: Melash Anteneh Agezew , Bytyqi Bekir , Nyandi Muhoja Sylivester , Vad Attila Miklós , Ábrahám Éva Babett
Published: March 2023

How crop biodiversity adapts to drought conditions and enhances grain yield became the most important issue facing agronomists and plant breeders at the turn of the century. Variations in genetic response, inadequacy of nutrients in the soil, and insufficient access to nutrients are factors that aggravate drought stressors. The development of screening tools for identifying drought tolerance is important in the deployment of durum wheat varieties suited to drought-prone environments. An experiment was conducted to evaluate durum wheat varieties under a range of nutrient supplies in naturally imposed drought conditions. The treatments consisting of two nitrogen regimes (i.e., control and 60 kg ha−1), four durum wheat varieties, and three types of nutrients (control, sulfur, and zinc) that were arranged in a split-split plot design with three replications. Both foliar-based sulfur and zinc fertilization were employed at the flag leaf stage, at a rate of 4 and 3-L ha−1, respectively. The results showed a significant (p < 0.05) genetic variation in chlorophyll concentration, grain protein content, tillering potential, and leaf area index. Varieties that contained better leaf chlorophyll content had improved grain yield by about 8.33% under 60 kg/ha nitrogen. A combined application of nitrogen and zinc at flag leaf stage significantly improved grain yield of Duragold by about 21.3%. Leaf chlorophyll content was found to be a more important trait than spikes per m2 to discriminate durum wheat varieties. Foliar application of sulfur increased the grain yield of drought-stressed plants by about 12.23%. Grain yield and protein content were strongly correlated with late-season SPAD readings. Significant (p < 0.05) correlation coefficients were obtained between normalized difference vegetation index, leaf area index, grain yield, and protein content with late-season chlorophyll content, revealing the importance of chlorophyll content in studying and identifying drought-tolerant varieties.