bluuebunny/crossref_metadata_2025 huggingface dataset:
In situ Identification of Mononuclear Cells in Lichen planus
Authors: Tosca A. , Varelzidis A. , Michalopoulos M. , Georgala S. , Stratigos J.
Published: October 2009

In this study, the in situ immunological typing of cell populations in lichen planus was attempted. T lymphocytes and suppressor/cytotoxic subsets, B lymphocytes, macrophages, immunocytes and Langerhans’ cells were studied by one or more technical parameters and semiquantitative assessment of T cell populations were carried out. A critical evaluation of assays for T cell characterization was also attempted. T cells were found predominant in lichen planus infiltrate but macrophages were also many. Langerhans’ cells were increased in the epidermis compared to normal skin and contact dermatitis.
Altération des loci minoris resistentiae du derme dans la photosclérose
Authors: Pierard G.E. , Pierard-Franchimont C. , Lapière C.M.
Published: October 2009

The resistance to traction of the dermo-epidermal junction and of the superficial vascular plexus is altered by oral photochemotherapy. The dermo-epidermal junction is weakened when the resistance of vascular walls increases. These modifications are related to the histological alterations occurring during photosclerosis induced by PUVA.
Morphologische Untersuchungen der Papillomatosis confluens et reticularis bei Diabetes mellitus
Authors: Hagedorn M. , Schlachter A.
Published: October 2009

Macroscopically papillomatosis confluens et reticularis (PCR) is a typical dermatosis with three different clinical forms. Histologically the characteristics are orthokeratosis, papillomatosis and hyperpigmentation. A case report of PCR and diabetes mellitus reveals further histological factors, these being interstitial and intracellular edema in the epidermis and a homogenization of collagen and rarefication of elastic fibres. Ultrastmcturally intracytoplasmic lipid vacuoles in the basal and suprabasal squamous cell layer were a prominent feature. These findings could be demonstrated in normal and PCR skin, which until now has not been described in the skin of diabetes mellitus patients. The question arises if PCR can be interpreted as a symptom of a fat metabolism disease in which unknown additional factors may play a role.
Relations entre les taux plasmatiques du 8-méthoxypsoralène et l’effet phototoxique
Authors: De Bersaques J. , Monbaliu J.G. , Hindryckx Ph.
Published: October 2009

Plasma concentrations of 8-MOP were studied in 6 subjects at three dose levels and the minimal phototoxic dose determined after 60, 120 and 180 min. Although there is an inverse correlation between these two values, none of the eight mathematical expressions examined gave a perfect fit in all cases.
A Comparison of the Potencies of Several Diluted and Undiluted Corticosteroid Preparations Using the Vasoconstrictor Assay
Authors: Kirsch J. , Gibson J.R. , Darley C.R. , Burke C.A.
Published: October 2009

10 subjects were assessed using the vasoconstrictor assay technique in a double-blind study in order to evaluate the relative potencies of several diluted and undiluted proprietary corticosteroid preparations. Dermovate ointment achieved a significantly higher score than any other preparation but there was no significant difference between the scores for Betnovate ointment (betamethasone valerate 0.1%), Propaderm Forte cream (beclomethasone dipropionate 0.5%), Propaderm ointment (beclomethasone dipropionate 0.025%), Nerisone Forte ointment (diflucortolone valerate 0.3%), and Nerisone ointment (diflucortolone valerate 0.1%). Furthermore, no significant difference in scores could be demonstrated between Adcortyl ointment (triamcinolone acetonide 0.1%), Ledercort ointment (triamcinolone acetonide 0.1%) and extemporaneous dilutions of these ointments 1 part in 4 in their recommended diluents (triamcinolone acetonide 0.025%). The relevance of these findings to clinical practice is discussed.
Eosinophilic Fasciitis
Authors: Boiesen Mads , Keiding Lis M. , Thomsen Kristian
Published: October 2009

An 80-year-old woman with eosinophilic fasciitis (EF) is presented. Besides symptoms indicative of EF, the patient expressed features of other autoimmune disease with elevated ANA, anti-DNA, serum-aldolase and thyroid autoantibodies. Glucocorticoid treatment resulted in rapid improvement of laboratory parameters and after 6 months a clinical improvement was also observed.
Acute Gangrene of the Scrotum and Penis in a Patient with Acute Promyelocytic Leukemia
Authors: Patrizi A. , Bandini G. , Cavazzini G. , Sommariva F. , Veronesi S.
Published: October 2009

The authors describe a case of Fournier’s gangrene in a young man affected with acute promyelocytic leukemia. They emphasize the rarity of this disease especially in a patient affected with leukemia. Pseudomonas aeruginosa with the same strict antibiotic sensitivity has been found in cutaneous lesions and in several blood cultures. The Fournier’s gangrene etiology is discussed.
Malignant Melanoma in a Patient with Severe Psoriasis Treated by Oral Methoxsalen Photochemotherapy
Authors: Frenk E.
Published: October 2009

Report of a malignant melanoma occurring in a woman with severe pustular psoriasis treated for 5.5 years with photochemotherapy.
Treatment of Generalized Pustular Psoriasis with Ro-10-9359
Authors: Lorand T. , Pierard-Franchimont C. , de la Brassinne M.
Published: October 2009

4 patients suffering from generalized pustular psoriasis, von Zumbusch type, were treated with the aromatic retinoid Ro-10-9359. Lesions were completely cleared after 4 weeks of therapy. A maintenance dose was usually required to prevent relapses. Side-effects were often observed but always remained very mild. Ro-10-9359 represents the best available treatment for generalized pustular psoriasis.
The Histology of Eccrine Poromas: A Study of 14 Cases
Authors: Pylyser K. , De Wolf-Peeters C. , Marien K.
Published: October 2009

A histological study of 14 eccrine poromas in 14 different patients was conducted and the results correlated with the clinical data. Histologically, an eccrine poroma is an easily recognizable epithelial skin tumor. Three morphological variants can be identified: a benign, a premalignant or dysplastic, and an invasive, malignant form. These tumors hardly have a typical clinical appearance. Symptoms such as bleeding, pain and itching are suggestive of a possible malignant transformation. There seems to be a predilection for localization on the limbs and the head. Most of the lesions occur in patients above the age of 60. It is noteworthy that these tumors, at least those of the face, occur on actinically damaged areas.
A Curious Genetic Coincidence Found in a Study of Palmoplantar Keratoderma
Authors: Nielsen Povl Gamborg
Published: October 2009

In a study of hereditary palmoplantar keratoderma of the Unna Thost variety in the northernmost county of Sweden (Norrbotten) a genetic coincident between this inherited disorder and the autosomal dominant form of ichthyosis vulgaris was found. In the same family a patient with ichthyosis vulgaris combined with palmoplantar hyperkeratosis and hyperkeratotic plaques on the knees and the elbows appeared.
Activation of Fibroblasts Induced by Mononuclear Cells from Patients with Systemic Scleroderma and Inactivation by Mitogen Stimulation
Authors: Tamura Taeko , Ishikawa Hidekazu
Published: October 2009

Unstimulated mononuclear cell supernatants from patients with systemic scleroderma significantly augmented the DNA and collagen biosynthesis of 3T3 cells compared to normal mononuclear cells. This increase was suppressed by either a particular glycosaminoglycan, which from previous studies, has appeared to act as one of the tissue antigens in sclerotic skin, or concanavalin A stimulation.
Urticaria and Giardiasis
Authors: Veronesi S. , Palmerio B. , Negosanti M. , Tosti A.
Published: October 2009

This study was carried out on 50 patients affected with urticaria: Giardia lamblia was isolated in 6 patients (12%). The relationship between intestinal giardiasis and urticaria is discussed.
Effect of Oral Aromatic Retinoid (Ro 10-9359) on Human Papilloma Virus-2-Induced Common Warts
Authors: Gross Gerd , Pfister Herbert , Hagedorn Manfred , Stahn Roland
Published: October 2009

Persisting human papilloma virus (HPV) 2 induced common warts of a chronic lymphatic leukemia patient were orally treated with aromatic retinoid Ro 10-9359 (Tigason®). Clinically, the lesions improved rapidly. Virus-specific cytopathogenic effects (CPE), virus particles and viral DNA were no longer detectable. Therapy was discontinued because of the development of a liposarcoma, which led to a complete relapse of the cutaneous lesions. HPV-2 specific parameters, CPE and viral DNA, were restored. Comparison of the restriction enzyme cleavage patterns revealed that warts before and after therapy contained the same HPV-2 subtype. The implications of the observation on the effect of Tigason® on virus-induced papillomas are discussed, liposarcoma
Eccrine Nevus with Epidermal Changes
Authors: Imai Seiji , Nitto Heita
Published: October 2009

A 22-year-old woman with papular lesions on the extensor aspect of the left leg, present since childhood, with linear distribution is described. Histology of the lesion showed malformed eccrine sweat apparatus with ductal hyperplasia, in addition to the serrated configuration of the epidermis. It appears that the lesions of the eccrine apparatus in this case represent a nevus.
Development of a Malignant Proliferating Trichilemmal Cyst in a Patient with Multiple Trichilemmal Cysts
Authors: Saida T. , Oohard K. , Hori Y. , Tsuchiya S.
Published: October 2009

A case of multiple trichilemmal cysts is presented. After trauma, a large tumor developed on one of the cysts. The histologic features of this tumor were similar to those of proliferating trichilemmal cyst, but some of the tumor cells showed definite nuclear atypicality. The malignant potential of this tumor was confirmed by later development of metastases to the regional lymph nodes.
A Case of Trophoneurotic Bullae
Authors: Horiguchi Yuji , Miyachi Yoshiki , Imamura Sadao , Tanaka Maya
Published: October 2009

A 57-year-old woman who had sensorimotor polyneuropathy with dysgammaglobulinemia showed pea-sized tense blisters on the fingers. Histopathological features were intraepidermal multilocular bullae and degeneration of capillaries of the papillary dermis with decreased nerve components of the dermis. Clinicopathological findings indicate this case to be trophoneurotic bullae.
Efficacy of Etretinate (Tigason®) in Clearing and Prevention of Relapse of Palmoplantar Pustulosis
Authors: Lassus A. , Lauharanta J. , Juvakoski T. , Kanerva L.
Published: October 2009

A total of 40 patients with palmoplantar pustulosis (PPP) were initially treated with oral etretinate (Tigason) in an open trial with a maximum treatment period of 16 weeks. Remission, with only slight residual changes in some cases, was achieved in 26 patients (65%) who were randomized to either a low dose of Tigason or placebo. In the Tigason group, 7 of 11 patients were still in remission after 6 months while in the placebo group, remission persisted in 4 of the 10 patients who stayed in the study throughout the whole 6 months’ period. Alopecia led to stopping the treatment in 6 patients and desquamation of the healthy skin in 2 patients. Other side-effects were only mild. As a conclusion, Tigason shows a beneficial effect in the majority of patients with PPP and is better than placebo in preventing relapse of the disease but intolerable side-effects restrict its use in many patients.
A Randomized Trial of Etretinate (Tigason®) in Palmoplantar Pustulosis
Authors: Foged Erik , Holm Per , Larsen Poul Ølholm , Laurberg Grete , Reymann Flemming , Roesdahle Kresten , Ullman Susanne
Published: October 2009

50 patients with palmoplantar pustulosis (PPP) were randomized to 8 weeks of daily treatment with either oral etretinate, 1 mg/kg b.w. or placebo. Good or moderate effect was obtained in 18 of 20 patients on etretinate compared to 6 of 21 patients on placebo (p < 0.001). Etretinate proved to be significantly superior to placebo with regard to influence on the individual symptoms and signs of pustulosis. All patients on etretinate experienced some side effects from the mucous membranes, but they were generally mild. Treatment was discontinued after 4 weeks in 3 patients for reasons unrelated to treatment, in 4 for lack of effect (all on placebo) and in 2 for side effects (both on etretinate). Etretinate is a good alternative to other systemic treatments of PPP.
IgE and IgG4 Levels in Children with Atopic Dermatitis
Authors: Wüthrich B. , Benz A. , Skvaril F.
Published: October 2009

Serum IgE and IgG4 concentrations were determined in 102 children with atopic dermatitis (AD) of varying severity and activity. Total as well as specific IgE levels, determined by the radioallergosorbent test (RAST), were correlated with disease severity and the coexistence of atopic respiratory diseases. The IgG 4 levels of children with only AD, even in severe cases, were within the normal ranges of healthy children. In contrast, the IgG4 levels of children with both cutaneous and respiratory atopic manifestations were elevated, suggesting that IgG4 are probably associated with respiratory diseases but do not play any role in the pathogenesis of the skin disorder.
Variation in Mast Cell Numbers in Psoriasis and Lichen planus: Comparisons with Normal Skin
Authors: Walton Shernaz , DeSouza Eustace J.
Published: October 2009

This study has examined the influence of age, sex and site on the numbers of mast cells in normal human skin from 60 healthy Indian volunteers. 5-μm-thick paraffin-embedded sections were stained with 0.001% toluidine blue and the mean number of mast cells per mm3 estimated. Multivariate analysis of variance revealed significant effects of age, site and sex upon mast cell numbers with greater numbers in the facial skin of young females compared with arm skin of young patients of both sexes and older females. Mast cell numbers were also significantly higher in both involved and uninvolved skin of patients with psoriasis in contrast with increased numbers in involved skin only, observed in lichen planus. This is the first report of mast cell density in Indian Caucasian skin.
Unusual Immunofluorescence Findings in Pemphigus vegetans
Authors: Larsen Schultz , Clausen J.
Published: October 2009

An 84-year-old man with massive verrucous lesions in the intertriginous areas is reported. The clinical, histological and electron microscopical findings indicated pemphigus vegetans. However, in addition to the intraepidermal findings direct immunofluorescence showed a linear deposit of IgG and C3 at the basement membrane.
Joint Involvement in Psoriasis: Scintigraphic, Radiologic and Clinical Findings
Authors: Bachmann Elisabeth , Clemmensen Ole J. , Dyrbye Martin , Larsen Kim
Published: October 2009

The results of a double-blind prospective study on patients with uncomplicated psoriasis (Ps), psoriasis with arthritis (PA) and a control group (C) are reported. The three groups were matched for age and sex. In the Ps and C groups no significant difference of the radiographic and scintigraphic results was found. The PA group showed significantly more scintigraphic accumulations compared to the two other groups, but no connection between scintigraphy and joint symptoms was found. The patients in the Ps and PA groups were treated with zinc sulfate per os for 8 weeks with no change in the radiographic findings. The PA group showed less and the Ps group more scintigraphic lesions after treatment. During treatment a small but significant decrease in hemoglobin, serum iron and gamma globulin was shown.
Muscle Relaxing Agent in Cutaneous Leiomyoma
Authors: Abraham Z. , Cohen A. , Haim S.
Published: October 2009

The management of pain in cutaneous leiomyoma involving large areas of the body surface is problematic. The surgical approach is not practical and the pain in these cases is refractory almost to all analgesic agents. This is a description of a case in which a muscle relaxing agent proved to be the only effective therapeutic approach.
Silica Granuloma at the Site of Circumcision for Phimosis: a Case Report
Authors: Michalowski R.
Published: October 2009

The unique case of a 33-year-old man with a silica granuloma at the site of circumcision, performed 15 years previously for acquired phimosis, is reported. The lesion was probably produced by the deposit of talc in the surgical wound.
Perforating Cutaneous Mucinosis
Authors: Brenner S. , Ilie B. , Krakowski A.
Published: October 2009

A case is described in which a papulonodular eruption developed all over the body. Histologic examination of one of the lesions revealed the dermis to contain mucin (hyaluronic acid). In some areas there was perforation through the epidermis of the mucinous material.
Hyalinosis cutis et mucosae
Authors: Ishibashi A.
Published: October 2009

Electron microscopy revealed accumulation of fibrogranular materials associated with laminated basal lamina around the smooth muscle cells of tunica dartos (most strikingly) and of blood vessels, vascular endothelial cells, pericytes, myofibroblasts (not usual fibroblasts) as well as Schwann cells and perineuria. Around the presumably regressive and slightly shrunken sweat duct, a network of basal lamina containing fibrogranular materials was found in a configuration indicating that it would have surrounded the remnants of cells (involuted cells) of the sweat duct, probably consisting of old, undegradated, residual basal lamina. Consequently, it was suggested that hyalinosis cutis et mucosae might be caused by accumulation and invasion of basal lamina glycoprotein involving the type IV (plusV?) collagen into normal collagen fibers (bundles) due to defective degradation.
Circumscribed, Palmoplantar Keratoderma
Authors: Tezuka Tadashi
Published: October 2009

A case of hereditary, circumscribed, palmoplantar keratoderma was reported. Histologically, remarkable orthokeratotic hyperkeratosis was observed, which stained rather basophilic and more translucent than the normal stratum corneum. The stratum granulosum was not present except in the epidermis of the acrosyringium, but the nucleus completely disappeared during the keratinization process and no Feulgen-positive DNA was found. The disappearance of the nucleus did not synchronize with the formation of keratohyalin granules during the keratinization process. Electron microscopically, there were no electron-dense interfilamentous substances, but the marginal band formation occurred normally and the intercellular substances were found.
Recessive Dystrophic Epidermolysis bullosa and Multiple Squamous Cell Carcinomas
Authors: Carapeto F.J. , Pastor J.A. , Martin J. , Agurruza J.
Published: October 2009

A patient with recessive dystrophic epidermolysis bullosa who developed multiple squamous cell carcinoma involving both hands at the age of 24 is presented. We think this is an interesting case because of its clinical expressiveness and the difficulties in its treatment. The precociousness of development of the tumoral lesions in our patient and the rarity of the complication, were also remarkable and prompted us to report this case.
Granuloma annulare with Follicular Perforation
Authors: Bardach Harald G.
Published: October 2009

An instance of perforating granuloma annulare was observed in a 42-year-old female patient in which the necrobiotic material in the dermis was eliminated by a hair follicle. This had previously been described by the author in only 1 other case of perforating granuloma annulare. Transepithelial elimination may occur by the transepidermal and/or transfollicular route. Both pathways are possible in perforating granuloma annulare. Some factors are discussed which may be responsible for the predominance of one route over the other in various disorders of transepithelial elimination.
Treatment of Onychomycosis by Partial Nail Avulsion and Topical Miconazole
Authors: Rollman Ola
Published: October 2009

13 patients with distal subungual onychomycosis in a total of 48 dermatophyte-infected nails were treated with chemomechanical, partial nail avulsion followed by topical miconazole for 8 weeks. On examination, 6 months after cessation of therapy, 42% of the nails were cured by clinical and mycological criteria. The therapeutic response was related to the pretreatment extension of subungual hyperkeratosis. Periungual skin irritation was common during the initial avulsion period. Miconazole solution was well tolerated and this treatment modality proved to be a valuable alternative to other remedies for the treatment of onychomycosis limited to a few number of nails.
Relapsing Polychondritis Associated with Mixed Cryoglobulinemia
Authors: Sidi Yechezkel , Weinberger Abraham , Berliner Shlomo , Ben-Bassat Mina , Idesses Carlos , Feuerman Elazar J. , Pinkhas Jack
Published: October 2009

The case of a patient with mixed-type cryoglobulinemia and cutaneous necrotizing vasculitis, who later suffered from relapsing polychondritis affecting the auricle and the nose, is described. To the best of our knowledge, this combination is unique.
Lupus vulgaris: Demonstration of Circulating and Tissue-Bound Immune Complexes
Authors: Imamura Sadao , Yanase Keiko , Horiguchi Michiko , Ozaki Motoaki , Wakai Yoshito
Published: October 2009

2 cases of lupus vulgaris are reported. In both cases, the deposition of IgG, IgM and/or C3 were detected at the dermo-epidermal junction of the lesional skin. In case 1 the circulating immune complexes, as determined by the C1q-binding test, were elevated at the first visit, suggesting that the circulating immune complexes were deposited in the skin.
Tigason (Ro 10–9359) Treatment in an Alcoholic Patient with Psoriasis of Verrucous Type
Authors: Mørk N.J.
Published: October 2009

A 53-year-old man suffering from alcoholism and psoriasis verrucosa had previously been treated locally in the hospital with keratolytic agents. His condition improved, but subsequently he had a rapid relapse each time. After receiving Tigason (Ro 10–9359) his skin improved rapidly and he has now used Tigason for 1 year with excellent effect.
An Approach to the Treatment of Vitiligo by Khellin
Authors: Abdel-Fattah A. , Aboul-Enein M.N. , Wasset G.M. , El-Menshawi B.S.
Published: October 2009

An anticipated effect of khellin, related to its chemical structure, in the photochemotherapy of amelanosis has been investigated. In a double-blind clinical study, khellin has been orally administered to 30 vitiligo patients for 4 months with subsequent exposure to natural sunlight. At the end of the trial period. 5 patients out of 30 (16.6%) repigmented 90–100%; 7 cases (23.3%) repigmented 50–60% of the vitiliginous areas treated; 11 (36.6%) repigmented 25% or less, and 7 subjects (23.3%) showed negative response. 30 control subjects failed to repigment at all. The achieved repigmentation was stable after drug cessation for a period of 1 year. These data add a previously unreported effect for the non-psoralen compound, khellin, in the therapy of vitiligo.
Solcoderm in the Treatment of Solar and Seborrheic Keratoses
Authors: Feuerman Eleasar J. , Katzenelson Varda , Halevy Sima
Published: October 2009

Solcoderm treatment was applied to 46 patients with solar keratosis and 40 with seborrheic keratosis. Evaluation at regular follow-up over a 10-week period showed disappearance of the lesions without any remnant in most cases. Treatment was found to be effective, convenient, and with essentially no side effects.
Solcoderm as a Tool for the Plastic Surgeon
Authors: Hettich R.
Published: October 2009

In 243 cases of verruca vulgaris, about 85% of the epidermal efflorescences caused by the wart virus were cured by two or more applications of Solcoderm in ambulant therapy. Of 127 cases of verruca plantaris treated, about 70% were cured after an initial course of four applications and 80% after further courses of treatment. More than 80% of recurrences responded to retreatment. A favorable effect on the pain caused by the plantaris warts was reported by 95% of the patients treated. No delayed complications were observed after the use of Solcoderm. The rate of incapacity for work after Solcoderm treatment, a total of 41 man-days, was extremely low when compared with that following cryosurgery and other surgical measures which, unlike Solcoderm therapy, often require immobilization, dressings or avoidance of soap and water.
Topical Treatment of Condylomata acuminata with Solcoderm
Authors: Brokalakis J. , Goumouzas N. , Varelzidis A.
Published: October 2009

Of 85 patients with condylomata acuminata treated topically with Solcoderm, the lesions were apparently eradicated in all but 11 (12.9%), and recurrences were noted in 6 during a 3-month follow-up. Only 1 treatment was required in 55 (64.7%) of the treated subjects.
Treatment of Naevi and Warts by Topical Chemotherapy with Solcoderm
Authors: Burri P.
Published: October 2009

Solcoderm is a new liquid caustic preparation which is particularly indicated for the topical treatment of small cutaneous tumors. The liquid is easy and safe to handle. Among its advantages: local anaesthesia is not required and histological evaluation of treated skin tumors is possible. We have treated 33 naevocytic naevi (13 patients) and 214 viral warts (32 patients) by repeated superficial application of the new agent. Recurrences were observed in 3 patients. 2 of them had multiple skin warts, suggesting a selective immune deficiency rather than incomplete treatment as the prime responsible factor.
Monilethrix
Authors: Lubach Dietrich , Glowienka Frank , Castellucci Mario
Published: October 2009

A comparative examination of the hair of the members of a family with monilethrix was carried out. Scanning electron microscopy (SEM) was used in the examination. It could be shown that the hair of persons with monilethrix showed a clear irregularity in its surface structure. A corresponding pattern was found in the clinically healthy sister and the likewise healthy father. The surface of the mother’s hair showed a normal condition. The cuticle of the monilethrix appears to be very soft. The SEM method permits more exact examinations concerning the heredity of monilethrix.
Microenvironment of Woringer-Kolopp’s Disease
Authors: Geerts M.L. , Kaiserling E. , Kint A.
Published: October 2009

A localized form of ‘Pagetoid reticulosis’ (Woringer-Kolopp’s disease) is described morphologically. It can be shown that ultrastructurally the ‘Pagetoid cells’ are heterogenic and that different cell types can be distinguished: there are lymphoid cells, which often look like Lutzner cells, and nonlymphoid cells which can be characterized as indeterminate cells or Langerhans’ cells. Often a close topographical relation between lymphoid and nonlymphoid cells can be demonstrated. This finding is suggestive for a functional interaction between the lymphoid cells, which are most probably T cells, and indeterminate cells and Langerhans’ cells, which are known to be important for the thymus-dependent immune reaction. The presence of the nonlymphoid cell population in the epidermis in Woringer-Kolopp’s disease seems to build up the specific microenvironment for lymphoid cell reaction.
Squamous Cell Carcinoma Associated with Disturbance of the IgA System
Authors: Furukawa Fukumi , Taniguchi Shinkichi , Danno Kiichiro , Komura Jinro , Mizumoto Takashi , Kanoh Tadashi
Published: October 2009

A case of squamous cell carcinoma of the skin associated with disturbance of the IgA system is described. Immunological observations revealed a marked low level of serum IgA and disturbance of the secretory IgA synthesis in the rectal mucosa. After the surgical removal of the skin tumor, the serum level of IgA was increased to half the normal-range level. The relationship of the disturbance of the IgA system to the occurrence of squamous cell carcinoma is discussed.
Anhidrotic Ectodermal Dysplasia
Authors: Hatzis J. , Tosca A. , Moulopoulou-Karakitsou K. , Stratigos J. , Varelzidis A. , Capetanakis J.
Published: October 2009

In 2 patients with anhidrotic ectodermal dysplasia, we were able to show that the hypoplastic eccrine glandular elements may give rise to normal eccrine glands both anatomically and functionally, after repeated local application of acetylcholine. The perspectives of our findings for the therapeutic management of the anhidrotic ectodermal dysplasia are discussed and special attention is paid to the genetic background of the defect as well as the possible mode of action of acetylcholine.
Induktion eines lokalisierten Pemphigoids durch energiereiche Strahlen
Authors: Ernst T.-M. , Marsch W.C.
Published: October 2009

A case of localized bullous pemphigoid in a 79-year-old woman is reported. The symptoms developed 5 months following radiation treatment of breast cancer. Direct immunofluorescence investigations showed IgG and C3 deposition in the basement membrane zone (BMZ) of lesional skin. Serum BMZ antibodies (IgG, IgM) and C3 deposition were demonstrated. Light microscopic investigation revealed subepidermal blister formation. A cellular infiltrate consisted predominantly of lymphocytes and eosinophils in the upper dermis. Junctional blister formation, located within the lamina Iucida of the basement membrane, was confirmed by electron microscopy. Differential diagnoses and various possible etiologies are discussed.
Lymphocytotoxicity for Oral Epithelial Cells in Behçet’s Disease
Authors: Reimer G. , Djawari D.
Published: October 2009

Apart from nonspecifically altered laboratory data, enhanced chemotaxis of polymorphonuclear leukocytes to chemotactic stimuli, HLA-B5 and circulating cytotoxic lymphocytes for oral epithelial cells were demonstrated in a 21-year-old patient suffering from Behçet’s disease (BD). Pathological liver function became indicative of concomitant hepatic involvement. The pathogenetic role cytotoxic lymphocytes have on the oral mucosa in BD is discussed.
Weber-Christian Panniculitis with Immunological Abnormalities
Authors: Iwatsuki Keiji , Tagami Hachiro , Yamada Mizuho
Published: October 2009

A case of Weber-Christian pannuculitis in a patient with abnormalities in both cell-mediated and humoral immunity was reported. Negative or weak delayed hypersensitivity reactions to common antigens, and a lymphopenia in peripheral blood associated with decreased sheep erythrocyte rosette-forming cells were observed. Direct immunofluorescence studies demonstrated the depositions of C1q and C3 in the vessel walls and at the dermoepidermal junction in the lesional skin and the deposits of IgM and C1q in the vessels in histamine-injected uninvolved skin. The immunological abnormalities demonstrated in our case may have etiologic significance.
Skin Lesions in Chronic Alcoholic Pancreatitis
Authors: Barba A. , Piubello W. , Vantini I. , Cocchetto R. , Caliari S. , Vallaperta P. , Scuro L.A. , Sapuppo A. , Cavallini G.
Published: October 2009

The lack of information on skin lesions in patients with chronic alcoholic pancreatitis prompted us to carry out an investigation on 54 patients with well-documented alcoholic chronic pancreatitis, on 54-pair-matched controls and on 30 patients with alcoholic liver cirrhosis. This study suggests that in chronic pancreatitis, but not in alcoholic liver cirrhosis and in controls, an increased frequency of skin lesions as seborrheic dermatitis, comedones and oily and scaling skin is present. These changes do not seem to be directly related to chronic alcoholism and/or diabetes. It is hypothesized that the folate deficiency induced by chronic consumption of pancreatic extracts, probably worsened by maldigestion and malabsorption, may be the main pathophysiological factor involved in these skin lesions.
Variations d’activité de Paxe hypophyso-surrénalien au cours du traitement par une crème au bénétonide de triamcinolone à 0,075 g%
Authors: Meynadier J. , Guillot B.
Published: October 2009

The aim of this study was to estimate the percutaneous absorption of a new corticosteroid: triamcinolone benetonide as a 0,075% cream. After stimulation with exogenous ACTH, a decrease in plasma cortisol levels but a normal adrenocortisol response were noted in most patients.
Atypical Angioma serpiginosum: A Case Report
Authors: Michalowski R. , Urban J.
Published: October 2009

A case of angioma serpiginosum with changes is presented. Its presumable pathogenesis is discussed.
The Water Cushion in Dermatological Diagnostic Ultrasound
Authors: Weinraub Zwi , Brenner Sarah , Krakowski Anatol , Caspi Eliahu
Published: October 2009

A novel way of using diagnostic ultrasound in the examination of the skin is presented. A water-filled surgeon’s glove acts like a water-cushion, providing more detailed and precise information.
Does Mast Cell Protection plus Mediator Antagonism Surpass the Effect of a Classic Antihistaminic in the Treatment of Chronic Urticaria?
Authors: Demaubeuge J. , Tennstedt D. , Broux R.
Published: October 2009

A new type of antiallergic drug, oxatomide (60 mg daily), was compared with the antihistaminic, mequitazine (10 mg daily), in a 5-week double-blind randomized study involving 26 patients with chronic urticaria. In the 13 oxatomide-treated patients, papules, erythema and pruritus were significantly suppressed after 2 weeks, which was markedly more rapid than with mequitazine. Slight somnolence was reported by 3 patients on oxatomide and 1 on mequitazine; in the latter case, severe urine retention was also reported. Another patient on mequitazine had to discontinue treatment because of severe drowsiness.
Side Effects Due to RO 10-9359 (Tigason)
Authors: Foged Erik K. , Jacobsen Kjœr
Published: October 2009

In a retrospective study clinical and hepatotoxic side effects caused by Tigason treatment are investigated. The material consists of data on 27 patients with normal liver function tests at the beginning of treatment. The clinical side effects encountered were: dryness of lips and mucous membranes (n = 14), diffuse hair loss (n = 5), epistaxis (n = 1) and conjunctivitis (n = 1). Abnormal liver function tests (glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, lactate dehydrogenase and alkaline phosphatase) were found in 7 patients: 3 developed slight transient elevation of parameter during treatment, 2 transient elevation of more parameters, normalizing despite continued therapy in 1 and in the other normalizing after discontinuation. Finally 2 patients developed persistent elevation of one or more parameters. In the last 2 patients liver biopsy showed changes of toxic hepatitis.
Infection dermatophytique mixte du cuir chevelu
Authors: Grigoriu D. , Delacrétaz J.
Published: October 2009

A mixed infection induced by Microsporum canis and Trichophyton tonsurans has been observed on the scalp of a 10-year-old girl. Microscopy has shown microsporum-type endo-ectothrix parasitism on some hairs, whereas others exhibited a strictly trichophyton-type endothrix parasitism. This double parasitism was confirmed histologically (PAS coloration), and M. canis and T. tonsurans could be cultured. The infection was eradicated after 5 weeks of treatment with griseofulvin (750 mg/day per os) and local application of 1% Econazol spray solution twice a day.
Eczema Herpeticum in a Man of 68
Authors: Verbov Julian
Published: October 2009

A male of 68 with eczema herpeticum is described. He had dominant ichthyosis vulgaris complicated by an exfoliative dermatitis precipitated by an allergic contact dermatitis. The background of contact dermatitis seems most relevant in this patient.
Psoriasis of the Lips: The Unusual Köbner Phenomenon Caused by Protruding Upper Teeth
Authors: Brenner S. , Lipitz R. , Ilie B. , Krakowski A.
Published: October 2009

Psoriasis of the lips was observed in a 54-year-old female who had suffered from psoriasis vulgaris for 18 years. The psoriasis of the lips was preceded by protrusion of the upper teeth. Topical corticosteroid and later 5-fluorouracil treatment were ineffective. The disease recurred even after replacement of the vermilion by plain mucosa. The disease was successfully treated by replacement of the protruding teeth by a nonirritating prosthesis.
Porokératose de Mibelli des lèvres bilatérale et symétrique
Authors: Kanitakis C. , Ktenides M. , Tsoïtis G.
Published: October 2009

We report an exceptional case of porokeratosis of Mibelli in a 9-year-old girl. The lesions appeared when she was 4 years of age; they are located bilaterally and symmetrically on the lips. The clinical appearance suggests atrophic annular lichen planus rather than porokeratosis of Mibelli. Histopathological examination showed a typical picture of porokeratosis of Mibelli.
Revue: A propos des bêta-bloquants en dermatologie
Authors: Clerens A. , Guilmot-Bruneau M.M. , Defresne C. , Bourlond A.
Published: October 2009

The authors present a survey of the side effects of beta-blocking agents. Practolol has been linked with a lupus syndrome caracterized by biological abnormalities and eventually clinical signs; later on, other beta-blocking agents have been able to induce such manifestations. Thus, all beta-blocking agents proved hazardous and they must be prescribed with extreme caution in patients with immunological imbalance. Furthermore, pruritus and lichenoid or psoriasiform dermatitis have been documented. This must be kept in mind in the presence of any unspecific rash in elderly patients.
Bullous Sézary Syndrome
Authors: Zina G. , Bernengo M.G. , Zina A.M.
Published: October 2009

The clinical course of a patient with Sézary syndrome presenting under bullous form is described. The bullae were flaccid on a non-erythematous base. Indirect and direct immunofluorescence were both negative. In the peripheral blood WBC was high (54,000/mm3) and large cells with T lymphocyte properties and small cells with ‘null’ cell features were present. Blister fluid contained only large, E-rosette-positive and α-naphthylacetate esterase-positive Sézary cells. A remarkable spontaneous cyclicity was observed: marked reduction in the number of large circulating Sézary cells each time bullae appeared. This suggests that only the large cells were capable of migrating to the skin and from the skin to peripheral blood.
Lichen plan avec dépôts linéaires d’lgG et de C3 à la jonction dermo-épidermique
Authors: Morel P. , Perron J. , Crickx B. , Barrandon Y. , Civatte J.
Published: October 2009

Report of 4 cases of clinically and histologically typical lichen planus with a linear IgG and C3 deposit at the dermal-epidermal junction in involved (4/4) and healthy (2/2) skin, as detected by direct immunofluorescence. Indirect immunofluorescence was negative (3/3). In these 4 cases, the clinical aspect was different: there were no vesiculo-bullous lesions in case 1; case 2 and 3 were of the partly vesicular type with dermal-epidermal separation only in the involved skin; in case 4, bullae were present on both healthy and lesional skin. This suggests that there might exist a broad spectrum ranging from lichen planus without clinical vesiculo-bullous lesions, but with linear IgG and C3 deposits, to lichen planus associated with clinical, histological and immunological symptoms of bullous pemphigoid.
Variably Acid-Fast Bacteria in a Case of Systemic Sarcoidosis and Hypodermitis Sclerodermiformis
Authors: Cantwell, Jr. Alan R.
Published: October 2009

The histologic finding of variably acid-fast coccoid forms in all the available biopsy material (skin, lymph nodes, and lung) from a case of coexisting scleroderma-like cutaneous disease (hypodermitis sclerodermiformis) and systemic sarcoidosis is reported The morphologic size, shape, and staining characteristics of these microbes, along with the presence in the lung of ‘large bodies’, suggest that these microbes are cell wall deficient L forms of mycobacteria. Culture of the skin of the scleroderma-like lesion yielded Staphylococcus epidermidis, and the relationship of this isolate to the histologic findings of bacteria is disussed, as well as the possible pathogenic role played by L forms of mycobacteria in collagen disease and systemic sarcoidosis.
Granulomatous Rosacea Treated with Tetracycline
Authors: Veien N.K. , Stahl D. , Brodthagen H.
Published: October 2009

After 8 weeks of treatment with tetracycline, the cutaneous lesions of 10 patients with granulomatous rosacea cleared, while no improvement was seen in 3 patients with papular cutaneous sarcoidosis.
Association of Discoid Lupus and Malignant Lymphoma
Authors: Efira A. , Unger J. , Bougaenko A.
Published: October 2009

A patient with an association of discoid lupus and lymphoma is described. A relation between these two diseases, as in systemic lupus erythematosus, is suggested, perhaps via a viral etiology.
Perinuclear Halo Formation as an Indication of Phototoxic Effects
Authors: Emerit I. , Michelson A.M. , Martin E. , Emerit J.
Published: October 2009

Irradiation of fibroblasts in culture at 365 nm produces perinuclear halos which can be seen by visible microscopy. The role of superoxide radical anions in this process (possibly via photoreduction of endogenous flavins followed by reoxidation by molecular oxygen) is suggested since addition of superoxide dismutase (probably membrane bound) completely inhibits formation of the halos.
Biotyping and Determination of Protein A in Staphylococcus aureus Strains of Skin Origin
Authors: Pospíšil Leopold , Skalka Boris , Kabátová Anna
Published: October 2009

By means of biotyping we have investigated 150 strains of Staphylococcus aureus isolated from people with dermatologic complaints. We have used six main and three additional biotyping tests. The strains under investigation did not form a closed biotype, on the contrary, they showed a certain biotype plurality. The determination of protein A in 150 strains of S. aureus isolated from dermatologic processes of men, 15 strains of S. aureus of bovine origin and 50 strains of Staphylococcus with negative coagulase activity have brought the following results: all strains of S. aureus of skin origin (human strains) contain protein A in various quantities keeping within 2–64 U. Only 2 from 15 S. aureus strains of bovine origin contain protein A and there were none in 50 strains of Staphylococcus with a negative coagulase reaction.
Pseudoxanthoma Elasticum
Authors: Pasquali-Ronchetti Ivonne , Volpin Dino , Baccarani-Contri Miranda , Castellani Ines , Peserico Andrea
Published: October 2009

Ultrastructural and biochemical studies of the dermis from patients with pseudoxanthoma elasticum are described. Elastin fibers showed mineral deposits that were associated with an elastin material exhibiting altered affinity for the electron microscopical stains and altered ultrastructural organization. In the most affected patient the elastin was shown to be increased and to have an abnormal amino acid composition. In some patients the collagen fibers were laterally fused. The ground substance was increased as evidenced by electron microscopy and confirmed by a slight increase in uronic acids, hexosamines, and neutral sugars.
HLA Antigens in Jews with Pemphigus Vulgaris
Authors: David Michael , Zamir Rina , Segal Rina , Gazit Ephraim , Feuerman Eleasar J.
Published: October 2009

The association of HLA antigens with pemphigus in Jewish patients of various ethnic origins was investigated. Of 45 Ashkenazi patients, 31 (68.6%) had A26 (p < 10––5) and 32 (71.7%) had BW38 (p < 10––5). Among the 11 non-Ashkenazi patients, 7 (63.6%) had A26 and only 1 had BW38. The question whether the antigen A26 or BW38 is linked with the disease is discussed. Our findings may suggest that the primary association of pemphigus is with A26. This association may be stronger in Jewish male patients than in females. In view of the recent literature and our results it may be presumed that pemphigus in Jews is associated with antigens of Loci A and DR. No differences between pemphigus vulgaris and pemphigus erythematosus were observed.
Release of Betamethasone 17-Valerate from Extemporaneous Dilutions of a Proprietary Topical Cream
Authors: Magnus A.D. , Haigh J.M. , Kanfer I.
Published: October 2009

Six different vehicles for topical use were used to prepare 50% dilutions of Betnovate® (betamethasone 17-valerate, 0.1%) cream. Blanching assessment was undertaken immediately after preparing the various dilutions and at 1 and 3 months thereafter. Few statistically significant differences were noted between any of the preparations tested indicating that the rate of release of betamethasone 17-valerate is relatively unaffected by dilution. All preparations were assayed by a stability indicating high pressure liquid chromatographic technique for corticosteroid content. A diminution in the content of betamethasone 17-valerate in the E45 dilution was found 14 months after preparation. All other formulations tested were found to comply with label claim specifications.
Low Molecular Weight Dextran Therapy for Digital Ischaemia Due to Collagen Vascular Disease
Authors: Nordlind K. , Berglund B. , Swanbeck G. , Hedin H.
Published: October 2009

12 patients with digital ischaemia due to collagen vascular disease were treated with repeated infusions of low molecular weight dextran at intervals from 5 to 6 weeks. The patients were followed clinically and by capillary microscopy. In 5 patients an increased capillary blood flow was seen by capillary microscopy. The clinical changes consisted of a lower number of ulcers in 5 of 9 patients with ulcers and a reduction of cold intolerance in 8 of the 12 patients studied. 4 patients had no improvement at all from the treatment. A determination of dextran-reactive antibodies was also performed.
Zur Ultrastruktur der Fettzellen
Authors: Rupec M.
Published: October 2009

This report presents an ultrastructural study of normal subcutaneous fatty tissue. From well-known morphological facts on human adipocytes in adults we have been able to make the following additional observations: (a) Several lipid droplets were surrounded by a well-developed system of filaments; (b) material very similar (the same electron-density) to the central lipid droplet appeared within the smooth surfaced cisterns of the endoplasmatic reticulum; (c) complex lipid granules very probably corresponding to lipofuscin were present in the cytoplasm; (d) in the nuclei, often sphaeridia of the filamentous type appeared; (e) the quantity of so-called lipomicrons (electron-dense granules) is dependent on the method of fixation.
Immunopathological Studies on a Case of Sweet’s Syndrome
Authors: Nunzi E. , Crovato F. , Dallegri F. , Patrone F. , Cormane R.H.
Published: October 2009

Immunopathological studies in a case of Sweet’s syndrome revealed IgM- and IgE-bearing polymorphonuclear leucocytes in involved skin when the direct immunofluorescence technique was used. Circulating polymorphonuclear neutrophils showed defective chemotaxis with normal random migration, phagocytosis, killing, and hexose monophosphate shunt activity.
Percutaneous Absorption of Zinc in Acrodermatitis enteropathica
Authors: Parra Cristóbal A. , Smálik Ana V.
Published: October 2009

An 8-month-old girl with acrodermatitis enteropathica was treated with 25% zinc oxide paste, locally, in the diaper area. A rapid improvement of the symptoms was observed a week after initiation of the treatment.
Cobb-Syndrom: Assoziation mit verrukösem Angiom, ipsilateraler Hypertrophie der Extremitäten und Café-au-lait-Flecken
Authors: Zola L. , Mumenthaler M.
Published: October 2009

A case of Cobb syndrome with an ‘angioma verrucosum’ situated on a segmental skin area corresponding to the cord segment occupied by the spinal angioma is reported. Additionally, this patient had an ipsilateral hypertrophy of the extremities and cafe au lait spots, anomalies which are only in rare cases associated with the Cobb syndrome.
Syndrome de Stevens-Johnson et collagénose (syndrome de Sharp?)
Authors: Bader C. , Laugier P.
Published: October 2009

A 22-year-old woman with Stevens-Johnson syndrome is described. She also presented with swollen hands, Raynaud’s phenomenon and arthralgia, suggesting a Sharp syndrome.