bluuebunny/crossref_metadata_2025 huggingface dataset:
Meta-analysis of reported presacral myelolipomas, including a report of a new case
Authors: Xu Congde , Kasajima Atsuko , Novotny Alexander , Friess Helmut
Published: February 2023

Background

Presacral myelolipomas form a rare disease and are often found incidentally in imaging diagnostics.

Case presentation

In this study, we report the case of a 71-year-old caucasian female with an incidental finding of a retroperitoneal tumor on magnetic resonance imaging scan. This report aimed at presenting the clinical course of this patient with emphasis on analysis of pathological, clinical, and epidemiological features in a meta-analysis of reported cases.

Conclusion

Presacral myelolipomas are rare and its etiology remains unclear. Surgical resection is indicated in symptomatic lesions and lesions > 4 cm. More clinical and pathological research on this rare entity is warranted.
Suspected twin anemia polycythemia sequence in a dichorionic, diamniotic twin pregnancy: a case report
Authors: Jeyaseelan Tania , Shangaris Panicos , Efthymiou Athina , Martin Linzi , Story Lisa , Nanda Surabhi , Gupta Neelam , Al-Adnani Mudher , Marnerides Andreas , Nicolaides Kypros H. , Sankaran Srividhya
Published: January 2023

Background

Twin anemia polycythemia sequence is a rare complication in monochorionic twin pregnancy.

Case presentation

We describe a case of dichorionic twin pregnancy presenting with suspected twin anemia polycythemia sequence. A 31-year-old White female, on her third pregnancy, had a routine ultrasound scan at 12 weeks gestation, which demonstrated a dichorionic twin pregnancy with one placenta located in the anterior wall and the other in the posterior wall of the uterus. At 21 weeks, a scan demonstrated a 24% growth discordance between the two fetuses with normal Doppler studies and amniotic fluid. At 27 weeks, one twin showed signs of anemia and the other polycythemia; the fetal middle cerebral artery peak systolic velocity was high in the anemic fetus and low in the polycythemic twin (1.8 and 0.5 multiples of the median). An intrauterine blood transfusion was carried out and this increased the fetal hemoglobin concentration in the anemic twin from 3.5 to 12.5 g/dL. At 29 weeks, delivery by cesarean section was carried out because of evidence from middle cerebral artery peak systolic velocity of recurrence of anemia in one twin and worsening polycythemia in the co-twin; at birth the hemoglobin concentrations were 5.6 and 24.9 g/dL, respectively. Histopathological examination confirmed dichorionicity with no communicating vessels between the two placentas.

Conclusions

This is the first case of twin anemia polycythemia sequence in a dichorionic, diamniotic twin pregnancy where intrauterine blood transfusion was used to prolong the pregnancy by almost 2 weeks in a “twin anemia polycythemia sequence-like” setting.
Long-term lithium therapy and risk of chronic kidney disease, hyperparathyroidism and hypercalcemia: a cohort study
Authors: Boivin Elise , Le Daré Brendan , Bellay Romain , Vigneau Cécile , Mercerolle Marion , Bacle Astrid
Published: January 2023

Background

Lithium is well recognized as the first-line maintenance treatment for bipolar disorder (BD). However, besides therapeutic benefits attributed to lithium therapy, the associated side effects including endocrinological and renal disorders constitute important parameters in prescribing patterns and patient adherence. The objectives of this study is to (i) determine whether long-term lithium therapy is associated with a decrease in renal function, hyperparathyroidism and hypercalcemia and (ii) identify risk factors for lithium-induced chronic kidney disease (CKD).

Methods

We conducted a single-centered cohort study of adult patients (≥ 18 years) treated with lithium, who were enrolled at Rennes University Hospital in France between January 1, 2018 and June 1, 2020. Required data were collected from the patient’s medical records: demographics characteristics (age, sex, body mass index), biologic parameters (GFR, lithium blood level, PTH and calcium), medical comorbidities (hypertension and diabetes), lithium treatment duration and dosage, and length of hospitalization.

Results

A total of 248 patients were included (mean age: 60.2 ± 16.5 years). Duration of lithium treatment correlated with (i) deterioration of renal function estimated at − 2.9 mL/min/year (p < 0.0001) and (ii) the development of hyperparathyroidism (p < 0.01) and hypercalcemia (p < 0.01). We also noted that patients with lithium blood level > 0.8 mEq/mL had significantly lower GFR than patients with lithium blood level < 0.8 mEq/mL (61.8 mL/min versus 77.6 mL/min, respectively, p = 0.0134). Neither diabetes mellitus nor hypertension was associated with more rapid deterioration of renal function.

Conclusion

This study suggests that the duration of lithium treatment contribute to the deterioration of renal function, raising the question of reducing dosages in patients with a GFR < 60 mL/min. Overdoses has been identified as a risk factor for CKD, emphasizing the importance of regular re-evaluation of the lithium dose regimen. Also, long-term lithium therapy was associated with hyperparathyroidism and hypercalcemia. Particular vigilance is required on these points in order to limit the occurrence of endocrinological and renal lithium adverse effects.
Influence of habitat heterogeneity on avian diversity in the Rajparian Wildlife Sanctuary, Kashmir Himalaya
Authors: Bhat Aadil Hussain , Mir Altaf Hussain , Charoo Samina Amin
Published: January 2023

Background

The value of local and regional landscapes for avian conservation requires a thorough understanding of the diversity and structure of bird communities. Avifauna serves as an important biological indicator in monitoring the health of an ecosystem or environment. The present study was conducted to examine the relationship between avian diversity, richness, composition and habitat characteristics at the Rajparian Wildlife Sanctuary.

Results

Using geographic information systems and remote sensing techniques, we analyzed habitat heterogeneity based on land use and land cover classification. For sampling birds, extensive surveys were conducted in different land-use types from 2019 to 2021, following the line transect method. During the study period, 102 bird species were recorded from the five studied vegetation types of the study area, including one near threatened (Bearded Vulture) and one vulnerable (Kashmir Flycatcher) bird species. The highest numbers of avian species were recorded from the forest (71 species) (42.61 ± 16; mean ± SD) and the lowest from the rocky land-use type (12 species) (7.83 ± 1.95). The individual rarefaction and extrapolation curves showed higher species richness for forest and the lowest for rocky habitats. Numerous pairwise comparisons revealed significant differences in species richness among studied habitat types, except for riverine vs. grassland, scrub vs. grassland and rocky vs. riverine land uses. The partitioning of the spatio-temporal β-diversity patterns revealed a relatively large contribution of the turnover component to the observed overall dissimilarity compared to the nestedness component.

Conclusions

It can be concluded that avian communities in the Rajparian Wildlife Sanctuary are influenced by habitat heterogeneity, topography, and the availability of water. The results of the present study indicate that the Rajparian Wildlife Sanctuary provides an important habitat for the conservation of birds, as it harbors a rich avian diversity. The study is the first scientific survey of the avian habitat associations in the protected area and will serve as a baseline for future avian research, as well as for management implications in the region.
Irreversible Alterations of Susceptibility in Cushing's Disease: A Longitudinal QSM Study
Authors: Jiang Hong , Li Zhenghao , Sun Yuhao , Ren Jie , Yan Fuhua , Sun Qingfang , Wei Hongjiang , Bian Liuguan
Published: February 2023

Objectives

Chronic exposure to hypercortisolism is associated with accelerated aging and neurodegenerative diseases, while Cushing's disease (CD) is the most common form of endogenous hypercortisolism exposure. This study aimed to assess longitudinal susceptibility changes in CD using quantitative susceptibility mapping (QSM) before and after resolution of hypercortisolism.

Methods

In this study, 24 CD patients and 24 healthy controls underwent magnetic resonance imaging (MRI) with QSM. All CD patients underwent MRI scans before and after the curative operation.

Results

After resolution of hypercortisolism, irreversibly altered susceptibility values were found in the anterior cingulate cortex, frontal lobe, caudate, and red nucleus. These alterations were significantly correlated with the changes in gray matter/white matter volumes and clinical features. Additionally, decreased susceptibility was found in several regions in CD patients.

Conclusion

Chronic exposure to hypercortisolism may be related to susceptibility alterations and significantly correlated with altered brain volumes and clinical features. in CD patients. The decrease of susceptibility might suggest the involvement of the calcium deregulation in these alterations.
Using 68Ga-DOTATATE PET for Postoperative Radiosurgery and Radiotherapy Planning in Patients With Meningioma: A Case Series
Authors: Hintz Eric B. , Park David J. , Ma Daniel , Viswanatha Sirisha Devi , Rini Josephine N. , Schulder Michael , Goenka Anuj
Published: February 2023

BACKGROUND:

For patients with either an incompletely resected meningioma or recurrence after surgery, stereotactic radiosurgery is frequently used. MRI is typically used for stereotactic radiosurgery targeting, but differentiating tumor growth from postoperative change can be challenging. 68Ga-DOTATATE, a positron emission tomography (PET) radiotracer targeting the somatostatin receptor type 2, has been shown to be a reliable meningioma biomarker.

OBJECTIVE:

To evaluate the impact of 68Ga-DOTATATE on treatment planning in patients who had previously undergone meningioma resection.

METHODS:

We present a consecutive case series of 12 patients with pathology-proven meningioma who received a 68Ga-DOTATATE PET between April 2019 and April 2021. Treatment planning was performed first using MRI. DOTATATE-PET images were then used to assess accurate tumor identification.

RESULTS:

Ten patients had WHO Grade 2 meningioma, and 2 patients had Grade 1 tumor. Eight patients had recurrent meningiomas, and 4 patients had newly diagnosed disease. Overall, 68Ga-DOTATATE PET scans altered previously formulated treatment plans in 5 of 12 patients. In addition, 9 of 12 patients had disease foci not appreciated on MRI.

CONCLUSION:

In this series, incorporating 68Ga-DOTATATE PET imaging had clinical utility for most patients in whom it was used. It proved particularly adept in demonstrating intraosseous meningiomas, differentiating recurrence from postoperative changes, and identifying subcentimeter disease foci. It is an imaging modality that our center will continue to use as a means of improving postoperative treatment plans after the surgical resection of meningiomas.
Diastereomeric Effect on Bulk Photovoltaic Property and Polarized Electroluminescence in Ferroelectric Liquid Crystals Containing an Extended π-Conjugated Unit
Authors: Matoba Yuji , Uemura Shinobu , Funahashi Masahiro
Published: February 2023

We synthesized two diastereomers comprising the same π-conjugated unit. One diastereomer exhibited a smectic crystal phase in which the chromophores tilted 45 degrees from the layer normal and macroscopic polarization was induced by a DC bias application in a cooling process from the high temperature phase to the smectic crystal phase. The other diastereomer exhibited a smectic crystal phase in which the chromophores were parallel to the layer normal and macroscopic polarization was not induced. The bulk photovoltaic effect and polarization-induced electroluminescence were observed only in the polarized smectic crystal phase in which the chromophores tilted from the layer normal. In the bulk photovoltaic effect in the tilted smectic crystal phase doped with fullerene derivative, the open circuit voltage and short circuit current were 1.03 V and 100 µAcm−2 for white light illumination (20 mWcm−2), respectively. In the polarization-induced electroluminescence in the tilted smectic crystal phase, linearly polarized emission with the dichroic ratio exceeding 10 was obtained and the axis of the linearly polarized emission could be rotated 90 degrees by an inversion of a DC bias of poling treatment.
Prehospital emergency medical service utilization and associated factors among critically ill COVID-19 patients treated at centers in Addis Ababa, Ethiopia
Authors: Olani Ararso Baru , Beza Lemlem , Sultan Menbeu , Bekelcho Tariku , Alemayehu Michael
Published: February 2023

The majority of populations in developing countries are living in areas of no access or limited access to prehospital emergency medical services (EMS). In Addis Ababa, the reported prehospital EMS utilization were ranging from zero to thirty-eight percent. However, there is limited research on reasons for the low utilization of prehospital resources in Ethiopia. This study aimed to assess factors associated with prehospital EMS utilization among critically ill COVID-19 patients in Addis Ababa, Ethiopia. A hospital-based cross-sectional study was conducted to collect primary data from 421 COVID-19 patients in Addis Ababa between May and July 2021. Logistic regression was used to identify factors associated with prehospital service utilization. Andersen’s Behavioral Model was implemented to address independent variables, including predisposing, enabling, need, and health behaviors-related variables. The level of prehospital care utilization was 87.6%. Being married [AOR 2.6(95%; CI:1.24–5.58)], belief that self-transport is quicker than the ambulance [AOR 0.13(95%; CI: 0.05–0.34)], and perceptions that ambulance provides transportation service only [AOR 0.14(95%; CI:0.04–0.45)] were predisposing factors associated with prehospital service utilization while the source of referrals [AOR 6.9(95%; CI: 2.78–17.30)], and prior knowledge on the availability of toll-free ambulance calling numbers [AOR 0.14(95%; CI: 0.04–0.45)] were identified as enabling factors. Substantial proportions of critically ill COVID-19 patients used prehospital services to access treatment centers. Prehospital EMS utilization in this study varies by predisposing and enabling factors, particularly: marital status, source of referral, prior knowledge on the availability of toll-free ambulances, belief that self-transport is quicker than ambulances, and perceptions that ambulance provides transportation service only. Our findings call for further actions to be taken by policymakers including physical and media campaigns focusing on the identified factors.
Accuracy of the Sysmex UF-5000 analyzer for urinary tract infection screening and pathogen classification
Authors: Wang Hua , Han Fei-Fei , Wen Jian-Xun , Yan Zhi , Han Yan-Qiu , Hu Zhi-De , Zheng Wen-Qi
Published: February 2023

The screening performance of urine flow cytometry parameters (e.g., white blood cell and bacteria) for urinary tract infection (UTI) has been widely recognized. The majority of previous studies, however, investigated the screening performance of Sysmex UF-1000i urine flow cytometer. This study aimed to investigate the screening performance of Sysmex UF-5000 analyzer, a third-generation urinary flow cytometer, for UTI and its novel parameter named Gram flag for discriminating gram-positive and negative pathogens. Urine specimens sent to the clinical microbiology laboratory of our hospital for bacterial culture between September 13, 2021, and November 15, 2021, were prospectively and consecutively collected. The Sysmex UF-5000 analyzer was used to determine urine white blood cell (WBC) and bacteria simultaneously. A chemical strip was used to assess urine nitrate. UTI was defined as positive urine bacterial culture > 104 CFU /ml. The receiver operating characteristics (ROC) curve, nomogram, decision tree, and decision curve were used to determine the screening performance of urine WBC, nitrate, and bacterial. A total of 246 UTIs and 425 non-UTIs were enrolled. The areas under the ROC curve (AUCs) for WBC and bacterial were 0.74 and 0.86, respectively. The decision curve showed that urine bacteria had a higher benefit than WBC. The nomogram indicated that urine bacterial had the largest effect on the probability of UTI. The sensitivity and specificity of the decision tree were 0.69 and 0.95, respectively. The flag of Gram-negative had a positive predictive value (PPV) of 0.93 in patients with urine bacteria > 1367 /μl. Therefore, we conclude that urine bacteria determined by the Sysmex UF-5000 had higher screening performance and greater benefit than WBC. The decision tree can be used to improve the screening performance of routine urinary parameters. The flag of Gram-negative is a reliable indicator to confirm gram-negative bacteria infection in UTI patients.
A novel portable Raman scattering platform for antibiotic screening in pig urine
Authors: Wattanavichean Nungnit , Nimittrakoolchai On-uma , Nuntawong Noppadon , Horprathum Mati , Eiamchai Pitak , Limwichean Saksorn , Somboonsaksri Pacharamon , Sreta Donruethai , Meesuwan Sirilak
Published: January 2023

Background and Aim: Public health and food safety are gaining attention globally. Consumer health can be protected from chemical residues in meat by early detection or screening for antibiotic residues before selling the meat commercially. However, conventional practices are normally applied after slaughtering, which leads to massive business losses. This study aimed to use portable surface-enhanced Raman spectroscopy (SERS) equipped with multivariate curve resolution-alternation least squares (MCR-ALS) to determine the concentrations of enrofloxacin, oxytetracycline, and neomycin concentrations. This approach can overcome the problems of business loss, costs, and time-consumption, and limit of detection (LOD). Materials and Methods: Aqueous solutions of three standard antibiotics (enrofloxacin, oxytetracycline, and neomycin) with different concentrations were prepared, and the LOD for each antibiotic solution was determined using SERS. Extracted pig urine was spiked with enrofloxacin at concentrations of 10, 20, 50, 100, and 10,000 ppm. These solutions were investigated using SERS and MCR-ALS analysis. Urine samples from pigs at 1 and 7 days after enrofloxacin administration were collected and investigated using SERS and MCR-ALS to differentiate the urinary enrofloxacin concentrations. Results: The LOD of enrofloxacin, oxytetracycline, and neomycin in aqueous solutions were 0.5, 2.0, and 100 ppm, respectively. Analysis of enrofloxacin spiking in pig urine samples demonstrated the different concentrations of enrofloxacin at 10, 20, 50, 100, and 10,000 ppm. The LOD of spiking enrofloxacin was 10 ppm, which was 10 times lower than the regulated value. This technique was validated for the first time using urine collected on days 1 and 7 after enrofloxacin administration. The results revealed a higher concentration of enrofloxacin on day 7 than on day 1 due to consecutive administrations. The observed concentration of enrofloxacin was closely correlated with its circulation time and metabolism in pigs. Conclusion: A combination of SERS sensing platform and MCR-ALS is a promising technique for on-farming screening. This platform can increase the efficiency of antibiotic detection in pig urine at lower costs and time. Expansion and fine adjustments of the Raman dataset may be required for individual farms to achieve higher sensitivity.
A New Ultraminiaturized Low-profile and Stable FSS with 2.5D Structure for 900 MHz ISM Band
Authors: Jales Duarte Mychael , Gomes D'Assunção Júnior Adaildo , da Silva Neto Valdemir Praxedes , Gomes D'Assunção Adaildo
Published: February 2023

This paper presents a new 2.5D ultraminiaturized frequency selective surface (FSS) structure to operate in the 900 MHz ISM band (902 to 928 MHz), for application in the Wi-Fi HaLow. The proposed FSS simulation and design are performed using ANSYS HFSS software and equivalent circuit model (ECM). The development of the proposed 2.5D FSS is based on meander-line-based conducting patches and has required the simulation and design of typical (2D) and 2.5D structures. An equivalent circuit model was proposed and presented very accurate results. For comparison purpose, a prototype is fabricated and measured. Agreement is observed between simulation and measurement results.
Comparison of methods to assess the accuracy of the incorporation of censored chemical data in descriptive statistical analysis of contaminated groundwate
Authors: Santos Vinicius Rodrigues dos , Bacellar Luis de Almeida Prado , Catapreta Cícero Antônio Antunes
Published: January 2023

Chemical analyses of groundwater often present data sets with censored values, i.e., below the detection limit (LOD). When the proportion of censored values is significant, descriptive (mean, median and standard deviation) or exploratory geochemical analysis may be impaired. Ignoring such data or replacing them with some predetermined value is not always the recommended alternative. Thus, the objective of this research is to investigate the applicability of four methods in estimating censored chemical data from an area with contaminated groundwater. Three statistical methods were used: parametric (Maximum Likelihood Estimation, MLE), non-parametric (Kaplan-Meier, KM) and robust (Order Regression Methods, ROS), in addition to the traditional method of direct replacement of censored data, using LOD/2. The MLE, assuming a Gaussian distribution of the data (MLE-no), yielded allowable substitution factors, close to 0.5, similarly to the traditional substitution method (LOD/2). Validation with complete datasets with the same estimation methods and considering three artificial LOD attested to the good results of MLE-no and ROS with 25% and 50% of censored data, respectively, as well as LOD/2. The first two methods are preferable to LOD/2 as they are statistically based. It is recommended in future studies that such estimation methods be combined with other geostatistical treatments to improve the spatial analysis of hydrochemical datasets.
Mapas de zonas potenciais de recarga da água subterrânea como uma nova ferramenta para a segurança hídrica do abastecimento público
Authors: De Vargas Tiago , Sgorla Vinícius , Belladona Rossano , Vedana Luiz Alberto
Published: January 2023

O desenvolvimento socioeconômico das cidades é dependente da segurança hídrica do abastecimento público. A identificação das zonas potenciais de recarga é fundamental para a gestão e planejamento dos recursos hídricos, tendo em vista garantir o fornecimento de água potável. O mapa de zonas potenciais de recarga de água subterrânea pode ser um instrumento facilitador para auxiliar a tomada de decisão nesse âmbito. A proposta deste estudo é identificar cartograficamente as zonas potenciais de recarga de três pequenas bacias hidrográficas urbanas destinadas ao abastecimento público de Caxias do Sul, RS. A metodologia aplicada considerou seis critérios do meio físico: densidade de lineamentos, densidade de drenagem, forma do terreno, uso e cobertura do solo, tipo do solo e declividade do terreno. Os pesos atribuídos para cada critério foram definidos através do método de análise hierárquica de processo. A modelagem cartográfica para a obtenção do mapa de zonas potenciais de recarga foi desenvolvida em software de SIG. As zonas potenciais de recarga classificadas como níveis baixo e moderado são dominantes nas três bacias hidrográficas, representando entre 79,54 e 84,57% das áreas avaliadas. Por outro lado, o nível elevado está caracterizado entre 15,43 e 20,46% das áreas das bacias, sendo esse nível o mais favorável à recarga. Os critérios com maior influência nas zonas de recarga foram a forma do terreno, uso e cobertura do solo, tipo do solo e declividade do terreno. O mapa de zonas potenciais de recarga pode ser uma nova ferramenta aos estudos de segurança hídrica, especialmente voltados ao abastecimento público municipal.
Avaliação da capacidade exploratória de aquíferos fraturados: um estudo de caso para os sistemas aquíferos da porção sul do Rio Grande do Sul, Brasil
Authors: Gaspar Mauren , Oliveira Christie Helouise Engelmann de , Tognoli Francisco Manoel Wohnrath
Published: January 2023

Para realizar estudos hidrogeológicos é necessário caracterizar sistemas aquíferos por meio através de dados qualitativos e quantitativos como análises litológicas e análises hidroquímicas, capacidades específicas dos poços, vazão, salinidade, e pH. O presente estudo apresenta uma avaliação hidrogeológica da porção sul do Escudo Sul Rio-Grandense (ESRG) englobando 39 municípios do estado do Rio Grande do Sul, Brasil. Foram utilizados dados de lineamentos extraídos de imagens SRTM, dados aeromagnetométricos, dados hidrogeológicos de 885 poços tubulares e dados GIS foram integrados para caracterização hidrogeológica. Para avaliação estrutural, foram traçados lineamentos baseados na morfologia do terreno nas imagens SRTM, em diferentes escalas (1:400.000; 1:250.000). Além do mais, foram usados dados aeromagnéticos para como a compartimentação estrutural. A avaliação estrutural foi utilizada para identificar a correlação morfoestrutural com a radiação magnética e a capacidade específica dos poços. Os resultados indicaram a ocorrência de três domínios geofísicos para cada tratamento de dado aeromagnetométrico (Amplitude do Sinal Analítico e Primeira Derivada Vertical). O domínio PDVD1, baseado no processamento de primeira derivada vertical, foi identificado como núcleos de falha por não coincidir com poços produtores, seguindo tendências NW-SE e, subordinadamente, SW-SE. O domínio PDVD2 apresenta menor persistência dos lineamentos com direção preferencial SW-NE e, subordinadamente, NW-SE, identificado como zona de dano por coincidir com áreas cristalinas com poços de maior capacidade específica. Esses resultados estruturais reforçam as tendências NE-SW e NW-SE do ESRG, seguindo trends dentro dos domínios geofísicos. Para a avaliação e classificação dos sistemas aquíferos dos poços foram utilizados dados de 1495 poços tubulares, analisado e processado a partir de scripts escritos em linguagem Python. Dos 885 poços filtrados, 211 poços fizeram intersecção com lineamentos na escala 1:400.00, e 588 poços intersectaram-se com lineamentos na escala 1:250.000. Assim, o estudo corrobora a eficiência para análises com escala 1:250.000 para estudos regionais, bem como a eficiência de linguagem de programação aplicada para estudos e avaliação hidrogeológica.
Prognóstico do potencial da contaminação hídrica superficial e subterrânea dos principais agrotóxicos comercializados no Estado de Goiás
Authors: Queiroz Liliana Alves Pereira , Goulart Adilson Correia , Goulart Simone Machado , Santos Joao Paulo Victorino
Published: January 2023

O Estado de Goiás é um importante centro agroindustrial brasileiro, a ocupação do solo é voltada principalmente para o plantio de soja, milho, cana-de-açúcar, feijão, tomate, entre outros. Devido à grande extensão agrícola, Goiás é o segundo maior consumidor de agrotóxico da região Centro-Oeste. Desta forma, esta pesquisa teve como objetivo realizar um prognóstico do potencial de contaminação hídrica dos principais agrotóxicos comercializados no Estado. Para o estudo foram utilizadas as propriedades físico-químicas destas substâncias as quais foram aplicadas aos índices GUS, LEACH, GOSS e Constante de Henry. Para a seleção dos agrotóxicos, priorizou os 30 princípios ativos cuja comercialização média foi superior a 100 toneladas nos últimos 5 anos. Os resultados obtidos apontam que os agrotóxicos comercializados em Goiás apresentam de moderada a alta probabilidade de lixiviação, cerca de 46%; Médio a alto potencial de transporte adsorvidos ao sedimento; Grande parcela, 50%, apresentaram alto potencial de transporte dissolvidos em água; Volatilidade moderada a alta. Além disso, os agrotóxicos comercializados no Estado de Goiás apresentam propensão à contaminação ambiental. Desta forma, é preciso que a aplicação seja coordenada por um profissional capacitado, seguir as orientações de aplicação dos mesmos e investir em práticas agrícolas que diminuam a aplicação de agrotóxicos.
From Aesthetic Virtues to God:
Authors: Miksa Rad
Published: January 2023

I argue that the aesthetic theoretical virtues of beauty, simplicity, and unification, as well as the evidential virtue of explanatory depth, can transform theistic-friendly personal cause (PC) arguments—like the kalām cosmological argument (KCA) and the fine-tuning argument—into stand-alone arguments for monotheism. The aesthetic virtues allow this by providing us with the grounds to rationally accept a perfect personal cause (i.e., God) as the best PC to believe in given the success of some PC argument. Using the KCA as an example, I argue that, once the KCA is accepted and a PC believed in, then a theory that posits a perfect PC as the cause of the universe is more beautiful, simpler, and has more unification and explanatory depth than the imperfect PC normally posited by the KCA’s standard conceptual analysis. And the same would hold true for any imperfect PC. Thus, once a PC argument has been accepted, the perfect PC theory is preferable to hold over any other PC theory. Finally, I address various objections to this reasoning.
How brain diseases affect the lower urinary tract function?
Authors: Sakakibara Ryuji , Yamamoto Tatsuya , Sekido Noritoshi , Sawai Setsu
Published: January 2023

This article reviewed brain mechanism of the lower urinary tract (LUT). Among autonomic nervous systems, LUT is unique in terms of afferent pathophysiology; bladder sensation is perceived soon after the storage phase and throughout the voiding phase. Within the brain, this is measured in experimental animals by the firing of single neurons and in humans by evoked potentials/functional neuroimaging. The evidence indicates that sphincter information goes up to the precentral motor cortex and other brain areas, and bladder information goes up to the insular cortex (IC)/anterior cingulate (ACG) and further to the prefrontal cortex (PFC). Another LUT-specific phenomenon is efferent pathophysiology: detrusor overactivity (exaggerated micturition reflex) occurs in brain diseases such as stroke (focal disease) and dementia with Lewy bodies (diffuse diseases, may overlap with each other). With the turning off and on of the brain-switch of micturition (at the periaqueductal gray [PAG]), there is a bladder-inhibitory PFC-IC/ACG-hypothalamus-PAG pathway, with interconnections via the PFC with a PFC-nigrostriatal D1 dopaminergic pathway and a PFC-cerebellar pathway. Brain diseases that affect these areas may cause a loss of the brain's inhibition of the micturition reflex, leading to detrusor overactivity. This has a significant clinical impact on patients and requires appropriate management.
Shellable tilings on relative simplicial complexes and their h-vectors
Authors: Welschinger Jean-Yves
Published: February 2023

An h-tiling on a finite simplicial complex is a partition of its geometric realization by maximal simplices deprived of several codimension one faces together with possibly their remaining face of highest codimension. In this last case, the tiles are said to be critical. An h-tiling thus induces a partitioning of its face poset by closed or semi-open intervals. We prove the existence of h-tilings on every finite simplicial complex after finitely many stellar subdivisions at maximal simplices. These tilings are moreover shellable. We also prove that the number of tiles of each type used by a tiling, encoded by its h-vector, is determined by the number of critical tiles of each index it uses, encoded by its critical vector. In the case of closed triangulated manifolds, these vectors satisfy some palindromic property. We finally study the behavior of tilings under any stellar subdivision.
Novel CPLANE1 c.8948dupT (p.P2984Tfs*7) variant in a child patient with Joubert syndrome
Authors: Wang Huiping , Nie Wensha , Wang Chunxia , Wang Zuohua , Zheng Yuxia
Published: February 2023

Joubert syndrome (JBTS) is a class of heterogeneous ciliopathy genetically associated with CPLANE1 mutations. The characteristics of clinical phenotypes and CPLANE1 variants were analyzed in a 2-month-old patient. A 2-month-old patient with JBTS was diagnosed after clinical evaluation including family history, physical examination, cerebral MRI, ultrasonography imaging, VEGG, ocular fundus examination, and comprehensive blood and urine testing. Whole exome sequencing (WES) was performed to detect CPLANE1 variants, and Sanger sequencing was used to confirm the variants. This JBTS patient presented with oculomotor apraxia, dysregulation of breathing pattern, and ataxia. MRI revealed poor continuity of cerebelli, batwing appearance, and molar tooth sign. This patient was noted with abnormal hematology, dysregulation of hepatic function, thyroid function, immunity, and renal function, and encephalopathy. CPLANE1 (c.8948dupT (p.P2984Tfs*7) and c.247G > T (p.G83X)) variants were noticed in the patient as a pathogenic variant and caused autosomal recessive inheritance. The JBTS patient with mutations in CPLANE1 (c.8948dupT (p.P2984Tfs*7) and c.247G > T (p.G83X)) developed JBTS phenotypes. The novel CPLANE1 c.8948dupT (p.P2984Tfs*7) variant will assist clinicians and geneticists in reaching a precise diagnosis for JBTS.
A new and improved method of library preparation for non-invasive prenatal testing: plasma to library express technology
Authors: Ren Meihong , Sun Guangxin , Kong Xiangsha , Zhang Lin , Ji Ying , Rao Huiying , Du Liuyezi , Zhang Xiaohong , Wu Qixi
Published: January 2023

Objectives

This study aims to develop a novel library preparation method, plasma to library express technology (PLET), to construct next-generation sequencing (NGS) libraries directly from plasma without cell-free DNA (cfDNA) isolation.

Methods

Peripheral blood samples (600) were obtained from a retrospective cohort of 300 pregnant women prior to invasive diagnostic testing. The samples were subsequently distributed between library preparation methodologies, with 300 samples prepared by PLET and 300 by conventional methods for non-invasive prenatal testing (NIPT) to screen for common trisomies using low-pass whole genome next generation sequencing.

Results

NIPT conducted on PLET libraries demonstrated comparable metrics to libraries prepared using conventional methods, including 100% sensitivity and specificity.

Conclusions

Our study demonstrates the potential utility of PLET in the clinical setting and highlights its significant advantages, including dramatically reduced process complexity and markedly decreased turnaround time.
On the asymptotics of the shifted sums of Hecke eigenvalue squares
Authors: Kim Jiseong
Published: January 2023

The purpose of this paper is to obtain asymptotics of shifted sums of Hecke eigenvalue squares on average. We show that for

X

2
3

+
ϵ

<
H
<

X

1
-
ϵ

{X^{\frac{2}{3}+\epsilon}<H<X^{1-\epsilon}}

there are constants

B
h

{B_{h}}

such that

∑

X
≤
n
≤

2
⁢
X

λ
f

⁢

(
n
)

2

⁢

λ
f

⁢

(

n
+
h

)

2

-

B
h

⁢
X

=

O

f
,
A
,
ϵ

⁢

(

X
⁢

(

log
⁡
X

)

-
A

)

\sum_{X\leq n\leq 2X}\lambda_{f}(n)^{2}\lambda_{f}(n+h)^{2}-B_{h}X=O_{f,A,%
\epsilon}(X(\log X)^{-A})

for all but

O

f
,
A
,
ϵ

⁢

(

H
⁢

(

log
⁡
X

)

-

3
⁢
A

)

{O_{f,A,\epsilon}(H(\log X)^{-3A})}

integers

h
∈

[
1
,
H
]

{h\in[1,H]}

where

{

λ
f

⁢

(
n
)

}

n
≥
1

{\{\lambda_{f}(n)\}_{n\geq 1}}

are normalized Hecke eigenvalues of a fixed holomorphic cusp form f.
Our method is based on the Hardy–Littlewood circle method. We divide the minor arcs into two parts

m
1

{m_{1}}

and

m
2

{m_{2}}

. In order to treat

m
2

{m_{2}}

, we use the Hecke relations, a bound of Miller to apply some arguments from a paper of Matomäki, Radziwiłł and Tao. In order to treat

m
1

{m_{1}}

, we apply Parseval’s identity and Gallagher’s lemma.
Almost Dedekind domains without radical factorization
Authors: Spirito Dario
Published: January 2023

We study almost Dedekind domains with respect to the failure of ideals to have radical factorization, that is, we study how to measure how far an almost Dedekind domain is from being an SP-domain. To do so, we consider the maximal space

ℳ
=

Max
⁡

(
R
)

{\mathcal{M}=\operatorname{Max}(R)}

of an almost Dedekind domain R, interpreting its (fractional) ideals as maps from

ℳ

{\mathcal{M}}

to

ℤ

{\mathbb{Z}}

, and looking at the continuity of these maps when

ℳ

{\mathcal{M}}

is endowed with the inverse topology and

ℤ

{\mathbb{Z}}

with the discrete topology. We generalize the concept of critical ideals by introducing a well-ordered chain of closed subsets of

ℳ

{\mathcal{M}}

(of which the set of critical ideals is the first step) and use it to define the class of SP-scattered domains, which includes the almost Dedekind domains such that

ℳ

{\mathcal{M}}

is scattered and, in particular, the almost Dedekind domains such that

ℳ

{\mathcal{M}}

is countable. We show that for this class of rings the group

Inv
⁢

(
R
)

{\mathrm{Inv}(R)}

is free by expressing it as a direct sum of groups of continuous maps, and that, for every length function

ℓ

{\ell}

on R and every ideal I of R, the length of

R
/
I

{R/I}

is equal to the length of

R
/

rad
⁡

(
I
)

{R/{\operatorname{rad}(I)}}

.
GKM actions on cohomogeneity one manifolds
Authors: Goertsches Oliver , Loiudice Eugenia , Russo Giovanni
Published: January 2023

We consider compact manifolds M with a cohomogeneity one action of a compact Lie group G such that the orbit
space

M
/
G

{M/G}

is a closed interval.
For T a maximal torus of G, we find necessary and sufficient conditions on the group diagram of M such that
the T-action on M is of GKM type, and describe its GKM graph.
The general results are illustrated on explicit examples.
Gruenberg–Kegel graphs: Cut groups, rational groups and the prime graph question
Authors: Bächle Andreas , Kiefer Ann , Maheshwary Sugandha , del Río Ángel
Published: January 2023

The Gruenberg–Kegel graph of a group is the undirected graph whose vertices are those primes which occur as the order of an element of the group, and distinct vertices p, q are joined by an edge whenever the group has an element of order pq.
It reflects interesting properties of the group.
A group is said to be cut if the central units of its integral group ring are trivial.
This is a rich family of groups, which contains the well-studied class of rational groups, and has received attention recently. In the first part of this paper, we give a complete classification of the Gruenberg–Kegel graphs of finite solvable cut groups which have at most three elements in their prime spectrum. For the remaining cases of finite solvable cut groups, we strongly restrict the list of the possible Gruenberg–Kegel graphs and realize most of them by finite solvable cut groups. Likewise, we give a list of the possible Gruenberg–Kegel graphs of finite solvable rational groups and realize as such all but one of them. As an application, we completely classify the Gruenberg–Kegel graphs of metacyclic, metabelian, supersolvable, metanilpotent and 2-Frobenius groups for the classes of cut groups and rational groups, respectively. The prime graph question asks whether the Gruenberg–Kegel graph of a group coincides with that of the group of normalized units of its integral group ring. The recent appearance of a counter-example for the first Zassenhaus conjecture on the torsion units of integral group rings has highlighted the relevance of this question. We answer the prime graph question for integral group rings for finite rational groups and most finite cut groups
Sobolev regularity for nonlinear Poisson equations with Neumann boundary conditions on Riemannian manifolds
Authors: Goffi Alessandro , Pediconi Francesco
Published: January 2023

In this paper, we study the Sobolev regularity of solutions to nonlinear second order elliptic equations with super-linear first-order terms on Riemannian manifolds, complemented with Neumann boundary conditions, when the source term of the equation belongs to a Lebesgue space, under various integrability regimes. Our method is based on an integral refinement of the Bochner identity, and leads to “semilinear Calderón–Zygmund” type results.
Applications to the problem of smoothness of solutions to Mean Field Games systems
with Neumann boundary conditions posed on convex domains of the Euclidean space will also be discussed.
Free polynilpotent groups and the Magnus property
Authors: Klopsch Benjamin , Mendonça Luis , Petschick Jan Moritz
Published: January 2023

Motivated by a classic result for free groups, one says that a group
G has the Magnus property if the following holds: Whenever two
elements generate the same normal subgroup of G, they are
conjugate or inverse-conjugate in G.
It is a natural problem to find out which relatively free groups
display the Magnus property. We prove that a free polynilpotent
group of any given class row has the Magnus property if and only if
it is nilpotent of class at most 2. For this purpose we explore
the Magnus property more generally in soluble groups, and we produce
new techniques, both for establishing and for disproving the
property. We also prove that a free center-by-(polynilpotent of
given class row) group has the Magnus property if and only if it is
nilpotent of class at most 2. On the way, we display 2-generated nilpotent groups (with
non-trivial torsion) of any prescribed nilpotency class with the
Magnus property. Similar examples of finitely generated,
torsion-free nilpotent groups are hard to come by, but we construct
a 4-generated, torsion-free, class-3 nilpotent group of Hirsch
length 9 with the Magnus property. Furthermore, using a weak
variant of the Magnus property and an ultraproduct construction, we
establish the existence of metabelian, torsion-free, nilpotent
groups of any prescribed nilpotency class with the Magnus property.
Optimization method for a multi-parameters identification problem in degenerate parabolic equations
Authors: Yang Liu , Deng Zui-Cha
Published: January 2023

In this paper, we study the well-posedness of the solution of an
optimal control problem related to a multi-parameters identification
problem in degenerate parabolic equations. Problems of this type
have important applications in several fields of applied science.
Unlike other inverse coefficient problems for classical parabolic
equations, the mathematical model discussed in the paper is
degenerate on both lateral boundaries of the domain. Moreover, the
status of the two unknown coefficients are different, namely that
the reconstruction of the source term is mildly ill-posed, while the
inverse initial value problem is severely ill-posed. On the basis of
optimal control framework, the problem is transformed into an
optimization problem. The existence of the minimizer is proved and
the necessary conditions which must be satisfied by the minimizer
are also established. Due to the difference between ill-posedness
degrees of the two unknown coefficients, the extensively used
conjugate theory for parabolic equations cannot be directly applied
for our problem. By carefully analyzing the necessary conditions and
the direct problem, the uniqueness, stability and convergence of the
minimizer are obtained. The results obtained in the paper are
interesting and useful, and can be extended to more general parabolic equations with degenerate coefficients.
On a flexible class of asymmetric mixture normal distribution and its applications
Authors: Satheesh Kumar C. , Anila G. V.
Published: January 2023

Here we consider a more flexible class of asymmetric mixture normal distribution and investigate some of its important statistical properties. We define its location-scale extension and discuss the method of maximum likelihood for estimating its parameters. Two real life data sets are considered for illustrating the usefulness of the model. Further, a simulation study is carried out for examining the efficiency of maximum likelihood estimators of the parameters of the distribution.
On the stochastic flow generated by the one default model in one-dimensional case
Authors: Khatir Yamina , Benziadi Fatima , Kandouci Abdeldjebbar
Published: January 2023

In this paper, we will study an important property on the regularity of the trajectories of the stochastic flow generated by a famous model in finance. More precisely, we prove the differentiability with respect to initial data of the solution of the stochastic differential equation associated with this model based on Gronwall’s lemma, Itô’s isometry and Burkholder–Davis–Gundy’s and Hölder’s inequalities. This is the main motivation of our research.
Fractional backward SDEs with locally monotone coefficient and application to PDEs
Authors: Saouli Mostapha Abdelouahab
Published: January 2023

In this work, we will try to weaken the hypothesis imposed by Hu and Peng. We will be concerned with finding the solution of locally monotone BSDEs associated to fBm. As an auxiliary
step, we study the existence and uniqueness of a solution to the monotone
backward SDEs associated to fBm. Then we connect these two kinds of
fractional backward SDEs with the corresponding semilinear partial differential equations (PDEs for short).
A Systematic Review of the Association Between Early Childhood Trauma and Borderline Personality Disorder
Authors: Yuan Yan , Lee Hyunji , Eack Shaun M. , Newhill Christina E.
Published: February 2023

Borderline personality disorder (BPD) is a debilitating clinical disorder associated with adverse impacts on multiple levels. While a high prevalence of childhood trauma has been noted, the ways such trauma impacts the development of BPD symptomatology remain unclear. In this systematic review, the authors examine the literature from 2000 to 2020, focusing on the association between trauma and BPD, and offer a comprehensive synthesis of possible etiological implications related to either one specific or multiple trauma types. In addition, results are analyzed based on commonly tested trauma parameters, including repeated exposure, polytrauma, onset, perpetrators, and gender. The authors also note some limitations in areas of sampling, measurement, causal inference methods, and data analyses. Results of this review point to several parameters of trauma that can be used to inform training for practitioners as well as enhance current interventions.
The Classification of Leading Sectors Utilized Weighting Technique Analysis
Authors: Nurfariswan Agi , Putra Dwi Ardi Wicaksana
Published: February 2023

Related to the previous studies, there are still questions about what sectors are produced from several economic based approaches each year. This study aims to determine the “very potential” business fields to be developed. This research was led purposively in Sukamara Regency, Kalimantan Tengah Province thinking about that macroeconomic exhibition information actually should be additionally improved. Auxiliary information got by documentation at the Central Statistics Agency, specifically GRDP at 2010 Constant Market Prices for the 2015-2020 period. Arrangement of business fields is done utilizing a weighting come closer from the estimation of Location Quotient, Growth Ratio Model, Sectoral Contribution Percentage and Growth Rate, Shift Share Analysis, and Overlay. The consequences of the review show the pattern of the improvement of the quantity of driving areas that are getting less and less and not in any manner observe any area that is completely equipped for satisfying the normal financial based methodology presumptions consistently. Moreover, the weighting system carried out proposes a new contribution in determining the leading sectors with a clearer classification. Therefore, the results of this study at the same time provide recommendations for the need for an analysis of the leading sector every year as consideration for regional planning.