bluuebunny/crossref_metadata_2025 huggingface dataset:
Explaining third-party reactions in interpersonal conflicts: A role-taking approach
Authors: Schwabe Johannes , Gollwitzer Mario
Published: June 2020

When people witness conflicts in their group, they can react in one of the following ways: (a) support one of the involved parties, (b) reconcile the conflict, (c) escalate the conflict, or (d) remain neutral and passive. These reactions can be conceptualized as social roles. Building on the assumption that role-taking in conflicts is intricately intertwined with the moral self-concept, the present research aims at testing three empirical hypotheses. First, taking a moral role is predicted by individual differences in the general relevance of a moral self-concept. Second, taking a moral role increases the situational moral self-concept. Third, the more relevant the general moral self-concept for an actor, the higher the situational moral self-concept increase after moral role-taking. Results from three studies using both experimental and correlational designs ( N = 961) support these hypotheses.
Effect of unsteady aerodynamic loads on driving safety and comfort of trains running on bridges
Authors: Han Yan , Liu Ye , Hu Peng , Cai CS , Xu Guoji , Huang Jiaying
Published: June 2020

In order to investigate the effects of unsteady aerodynamic loads on the driving safety and comfort of trains running on bridges, a three-dimensional and multi-body system model of train–track–bridge was established and the dynamic responses of the coupling system were calculated by combining the finite element software ANSYS with the multi-body dynamics software SIMPACK. The driving safety and comfort of a train running on a bridge under steady and unsteady aerodynamic loads were compared and analyzed. The effects of different crosswind speeds on the driving safety of the train running on the bridge under unsteady aerodynamic loads were studied. It is found that the index values of the driving safety and comfort of the train at the speed of 200–300 km/h without the wind loads are smaller (meaning safer) than those of the train under the wind loads. When the average speed of crosswind is 20 m/s, the driving safety assessment results of the train are better and its comfort assessment results are more conservative with considering the unsteady aerodynamic loads than the steady wind load case. When the average speed of crosswind is smaller than 10 m/s and the train speed is 250 km/h, the driving safety and comfort of the train on the bridge meet the requirements, and the level of stability can reach “good” or above. Through the analysis of driving safety of the train on the bridge under different crosswind speeds, the threshold values of safe driving were obtained, which can provide a better basis for the safe operation of trains on bridges.
Influence of sensible cooling load on indoor air distribution in an office room with ceiling cooling and mixing ventilation
Authors: Wu Xiaozhou , Wang Haichao , Gao Jie , Wang Fenghao
Published: June 2020

A mixing ventilation system integrated with a ceiling cooling system is a potential advanced heating, ventilation and air conditioning system for modern office buildings with a high sensible cooling load. This paper presents an evaluation of the effect of sensible cooling load on the indoor air distribution in a typical office room with mixing ventilation and ceiling cooling. The vertical distributions of indoor air temperature, air velocity and contaminant (CO2) concentration were evaluated by the vertical air temperature difference, turbulence intensity and contaminant removal effectiveness. The results showed that when the chilled ceiling surface temperature was increased from 15.0°C to 23.0°C and supply air temperature was decreased from 22.0°C to 19.0°C, the average vertical air temperature difference, turbulence intensity and contaminant removal effectiveness were 0.2°C–0.3°C, 27%–32% and 0.53–0.81 as both internal and external sensible cooling loads were 41.5 W/m2. Moreover, these evaluation indices varied slightly as the external sensible cooling load was increased from 41.5 W/m2 to 69.5 W/m2, whereas they varied greatly as the internal sensible cooling load was increased from 41.5 W/m2 to 69.5 W/m2. Hence, the external sensible cooling load could slightly affect the indoor air distribution, whereas the internal sensible cooling load could clearly affect the indoor air distribution in an office room with mixing ventilation and ceiling cooling.
Posterior approach, fracture diagnosis, and american society of anesthesiology class iii–iv are associated with increased risk of revision for dislocation after total hip arthroplasty: An analysis of 33,337 operations from the finnish arthroplasty register
Authors: Panula Valtteri J. , Ekman Elina M. , Venäläinen Mikko S. , Laaksonen Inari , Klén Riku , Haapakoski Jaason J. , Eskelinen Antti P. , Elo Laura L. , Mäkelä Keijo T.
Published: June 2020

Background and objective:

Dislocation is one of the most common reasons for revision surgery after primary total hip arthroplasty. Both patient related and surgical factors may influence the risk of dislocation. In this study, we evaluated risk factors for dislocation revision after total hip arthroplasty based on revised data contents of the Finnish Arthroplasty Register.

Methods:

We analyzed 33,337 primary total hip arthroplasties performed between May 2014 and January 2018 in Finland. Cox proportional hazards regression was used to estimate hazard ratios with 95% confidence intervals for first dislocation revision using 18 potential risk factors as covariates, such as age, sex, diagnosis, hospital volume, surgical approach, head size, body mass index, American Society of Anesthesiology class, and fixation method.

Results:

During the study period, there were 264 first-time revisions for dislocation after primary total hip arthroplasty. The hazard ratio for dislocation revision was 3.1 (confidence interval 1.7–5.5) for posterior compared to anterolateral approach, 3.0 (confidence interval 1.9–4.7) for total hip arthroplasties performed for femoral neck fracture compared to total hip arthroplasties performed for osteoarthritis, 2.0 (confidence interval 1.0–3.9) for American Society of Anesthesiology class III–IV compared to American Society of Anesthesiology class I, and 0.5 (0.4–0.7) for 36-mm femoral head size compared to 32-mm head size.

Conclusions:

Special attention should be paid to patients with fracture diagnoses and American Society of Anesthesiology class III–IV. Anterolateral approach and 36-mm femoral heads decrease dislocation revision risk and should be considered for high-risk patients.
Perceiving online public opinion: The impact of Facebook opinion cues, opinion climate congruency, and source credibility on speaking out
Authors: Leong Alisius D , Ho Shirley S
Published: June 2020

The novel affordances and unique features on social media have transformed the way people assess public opinion. Drawing on the spiral of silence (SOS) theory, this study examines the roles that user-generated comments (UGCs) and aggregated user representations (AURs), represented by reaction emojis, play in shaping perceptions of the opinion climate. It also investigates how features on the platform trigger perceptions of source credibility to influence willingness to speak out. Results from a 3 (opinion cues: UGCs-only vs AURs-only vs UGCs and AURs) × 2 (opinion climate congruency: congruent vs incongruent) × 2 (source credibility: high vs low) between-subjects experimental design revealed that audiences perceived reaction emojis to reflect public opinion. Source credibility was found to affect willingness to speak out and moderate opinion climate congruency. The findings extend the SOS theory by highlighting the significant role that novel affordances have on SOS components operating online. Implications of the findings were discussed.
Novel U-bending designed setups for investigating the spring-back/spring-go of two-layer aluminum/copper sheets through experimental tests and finite element simulations
Authors: Etemadi Ehsan , Naseri Abbas , Valinezhad Mohsen
Published: June 2020

This paper presents novel U-bending setups in order to investigate the effects of the curvatures created on the punch, die, or both on the spring-back/spring-go of the two-layer aluminum/copper sheets. Comparison of the new U-bending setups with the regular ones showed that the curvatures had important roles in reducing the spring-back/spring-go in the U-bending process. The results further indicated the good agreement between spring-back/spring-go and finite element simulations. Moreover, through finite element simulations, the effects of three effective parameters on reducing the spring-back/spring-go, including the curvature radius ( r) of the punch, the distance between curvature center and the fillet center ( d) in the punch, and the curvature radius at the end of the die ( R) were investigated. In achieving the desired state (90°), the results showed that the distance of curvature center from the fillet center ( d) was a more important parameter compared with the curvature radius at the end of the punch ( r) and the curvature radius at the end of the die ( R). This paper also focuses on the thicknesses of copper and aluminum as well as the stacking sequence of layers. Concerning the thicknesses of the implemented copper and aluminum change, the minimum angle of the spring-back/spring-go relative to the desired state was 75% Al/25% Cu thickness. Furthermore, the spring-back of aluminum/copper was lower than the copper/aluminum layer sheet. The effects of both thickness changing and stacking sequence of aluminum/copper layers on the spring-back/spring-go amounts of different sheets were due to the relocation of the neutral axis.
Psychological support for orthognathic patients: Who is doing what?
Authors: Sinnott Paula Mairead , Hunt Nigel , Shute Justin , Cunningham Susan
Published: June 2020

Objective:

To investigate: (1) orthodontists’ training experience in the psychological assessment of orthognathic patients and their wish for training/further training; (2) the availability of psychological support, referral patterns and outcomes after referral; (3) and adverse incidents prompting orthodontists to refer patients for psychological assessment.

Design:

Prospective cross-sectional study.

Methods:

A 25-item questionnaire was designed to investigate the above mentioned aims. After a pilot study, the questionnaire was distributed to all members of the Consultant Orthodontist Group, British Orthodontic Society.

Results:

Based on a 29.1% response rate (n = 102), 76.5% of respondents had undertaken training in identifying orthognathic patients who may benefit from psychological assessment. However, 90.2% favoured further training. All respondents believed that some orthognathic patients would benefit from referral; however, 31.3% of units referred no patients at all, mostly due to limited/no access (66.7%). Most referrals (68.9%) were to psychiatrists/psychologists with dentofacial deformity expertise, with 28.9% of units having such services onsite (14 different units). Psychological referrals had potentially useful outcomes, with 36.4% of respondents sometimes changing treatment plans following referral. Clinical incidents were experienced by 35.1% of respondents, prompting referral of patients for psychological assessment; such incidents included patient suicides (n = 4).

Conclusion:

Most respondents had trained in psychological assessment of orthognathic patients; however there was a large demand for further training. Clinicians value the psychological services available; however, limited availability may affect referrals for some respondents. Adverse incidents are of real concern and highlight the need to ensure that training and resources are provided to support orthognathic patients and teams.
Encountering and processing secondary traumatic stress during qualitative interviews with displaced Iraqis: a research note
Authors: Keyel Jared
Published: June 2020

Qualitative interviewing is an affective process that involves interacting with others on an interpersonal level. This approach can bring to the surface traumatic and painful memories for participants as well as for the interviewer. I recently completed research involving semi-structured interviews with individuals who sought refuge in the United States after the 2003 American invasion of their country. Although research focused primarily on participants’ lives after resettlement, a salient unexpected conversation topic was participants’ recollections of the war. Because of frequent recurrence of this topic, I experienced symptoms of secondary traumatic stress. I was unprepared for the emotional and psychological effects conducting research with those who have experienced trauma can entail. I situate my experience within the extant literature on risks to qualitative researchers and detail for other scholars engaged in similar work the possibility of encountering secondary traumatic stress, the importance of preparing for it, and potential strategies for addressing it.
Meanings and attitudes regarding education and household spending priorities of the new middle-class families in Brazil
Authors: Costa Filho Murilo Carrazedo , Rocha Angela Cavalcanti
Published: June 2020

This study investigates how meanings ascribed to education influence lower-income parents on investing (or not) in their children’s education, and how this in turn influences family expenditures and consumption priorities. Based on 62 ethnographic interviews with individuals who had ascended from poverty to the lower fractions of the Brazilian urban middle-class, we examine differences within a relatively homogeneous fraction in terms of social status and income. Three distinct groups emerged: (1) parents who live in the favelas (slums) and see school as an agent to keep children away from deviant behaviours, (2) parents who live in the favelas and invest in education as an enabler of upwards social mobility, and (3) parents from less affluent suburbs who pay for private education to keep their children from interacting with bad influences outside the territory. Even in socially segregated territories, meanings were shaped less by parents’ amount and composition of cultural and economic capitals, and more by their own experiences with the educational system and access to positive role models (or lack thereof). It appears that the meanings attached to education end up defining family expenditures, family budget and important consumption trade-offs. In addition, our findings reveal a subtle, fine-grained mechanism of distinction based on school choice among the class fraction’s members. We draw on Wilson’s social isolation theory to show how parents of similar economic and cultural capital, and who were socialized in a similar cultural milieu, ascribe different meanings to education, and the resulting differences in household consumption patterns. We thus offer insights on the different reproduction mechanisms at play within an economically disadvantaged social fraction that had moved from poverty to the lower urban middle-class in Brazil.
Bio-digital aesthetics as value system of post-Anthropocene architecture
Authors: Pasquero Claudia , Poletto Marco
Published: June 2020

It is timely within the Anthropocene era, more than ever before, to search for a non-anthropocentric mode of reasoning, and consequently designing. The PhotoSynthetica Consortium, established in 2018 and including London-based ecoLogicStudio, the Urban Morphogenesis Lab (Bartlett School of Architecture, University College London) and the Synthetic Landscape Lab (University of Innsbruck, Austria), has therefore been pursuing architecture as a research-based practice, exploring the interdependence of digital and biological intelligence in design by working directly with non-human living organisms. The research focuses on the diagrammatic capacity of these organisms in the process of growing and becoming part of complex bio-digital architectures. A key remit is training architects’ sensibility at recognising patterns of reasoning across disciplines, materialities and technological regimes, thus expanding the practice’s repertoire of aesthetic qualities. Recent developments in evolutionary psychology demonstrate that the human sense of beauty and pleasure is part of a co-evolutionary system of mind and surrounding environment. In these terms, human senses of beauty and pleasure have evolved as selection mechanisms. Cultivating and enhancing them compensate and integrate the functions of logical thinking to gain a systemic view on the planet Earth and the dramatic changes it is currently undergoing. This article seeks to illustrate, through a series of recent research projects, how a renewed appreciation of beauty in architecture has evolved into an operational tool to design and measure its actual ecological intelligence.
Dalbavancin for the Treatment of Complicated Gram-Positive Skin and Soft Tissue Infections
Authors: Petrakis Vasilios , Panagopoulos Periklis , Papanas Nikolaos
Published: June 2020

New antimicrobial agents have been developed to treat infections caused by methicillin-resistant Staphylococcus aureus and other multidrug-resistant pathogens. Dalbavancin is a novel semisynthetic lipoglycopeptide antibiotic, particularly active against methicillin-resistant Staphylococcus aureus. Due to its unique pharmacological characteristics and longer half-life, it can be administered once-weekly or every 15 days and in outpatient setting. Currently, it is indicated for complicated skin and soft tissue infections, but accumulating evidence points to its off-label efficacy in osteomyelitis and endocarditis. Further experience is still needed to increase our knowledge on the role of dalbavancin in a wider range of Gram-positive infections requiring prolonged antimicrobial treatment.
Stereotactic Body Radiotherapy for Prostate Cancer
Authors: Parikh Neil R. , Kishan Amar U.
Published: June 2020

Prostate cancer remains the most common and second most deadly cancer diagnosed amongst U.S. men. External beam radiotherapy is a standard-of-care definitive treatment option for localized prostate cancer and historically constituted an 8–9-week treatment course comprised of 39–45 doses of 1.8–2.0 Gy each (conventional fractionation, CF). Based on the notion that prostate cancer may respond favorably to a higher dose per day, considerable research efforts have been focused on characterizing the safety and efficacy profile of shorter and shorter radiation courses. Ultrahypofractionation (UHF) involves condensing the radiation course into just 5–7 treatments of 6–8 Gy each. When utilizing modern techniques that allow the precise sculpting of a dose distribution that delivers high doses to the prostate and lower doses to surrounding normal tissues over five or fewer treatments, this treatment is called stereotactic body radiotherapy (SBRT). Two randomized trials (HYPO-RT-PC and PACE-B) have compared UHF to longer radiation courses. The former demonstrated that UHF and CF have similar long-term toxicity and efficacy, while the latter demonstrated that modern SBRT has equivalent short-term toxicity as well. A separate report from a consortium of studies data provides prospective, albeit nonrandomized, data supporting the longer-term safety and efficacy of SBRT specifically. Thus, mounting high-level evidence suggests that SBRT is an acceptable standard care of option for men with localized prostate cancer.
Analysis of new molecular entity trends from 2006 to 2015 in Japan
Authors: Shibata Shoyo , Fukumoto Daigo , Ozaki Koken , Suzuki Takeshi
Published: June 2020

Japan is one of the largest pharmaceutical markets in the world, and as such, pharmaceutical companies are intensively conducting research and development of new drugs in Japan. However, information on Japanese pharmaceutical market profiles is limited. In this context, we elucidated the market characteristics and trends of new molecular entities approved between 2006 and 2015 in Japan. Among antineoplastic and immunomodulating agents, the highest number was first approved in the United States, and for nervous system drugs, the highest number was first approved in Europe. The alimentary tract and metabolism and the musculoskeletal system were the therapeutic areas for which the most drugs were approved for the first time in Japan. Most of the musculoskeletal system drugs were developed by Japanese companies, and most of the antineoplastic and immunomodulating agents were developed outside of Japan. Using various performance indexes, such as market forecasts and significance of clinical benefits, we determined that the number of new molecular entities and market size increased and the number of drugs with significant clinical benefits decreased. These results suggest that new molecular entity innovation by Japanese companies has been decreasing and the government’s comparative method for pricing does not work well in Japan.
Optimal attitude tracking control for an unmanned aerial quadrotor under lumped disturbances
Authors: Ding Li , Li Yangmin
Published: June 2020

The robust control problem in attitude tracking of an unmanned aerial vehicle quadrotor is a challenging task due to strong parametric uncertainties, large nonlinearities and high couplings in flight dynamics. In this paper, a continuous nonsingular fast terminal sliding mode controller based on linear extended state observer is proposed for attitude tracking control of a quadrotor under lumped disturbances. The proposed control method requires no prior knowledge of the attitude dynamics. It can ensure rapid convergence rate and high tracking precision due to terminal sliding mode surface and fast reaching law. The controller uses the linear extended state observer to reject the influence of both parametric uncertainties and external disturbances. Meanwhile, the nonsingular fast terminal sliding mode control strategy is designed to ensure the state variables to slide to desired points in finite time. To enhance the control performance, a self-adaptive fruit fly optimization algorithm is applied to parameters tuning of the proposed controller. The effectiveness of the proposed control approach is illustrated through numerical simulations and experimental verification.
Histopathologic Influences of Comorbid Smoking Status in Chronic Rhinosinusitis
Authors: Kuhar Hannah N. , Ganti Ashwin , Brown Hannah J. , Gattuso Paolo , Ghai Ritu , Mahdavinia Mahboobeh , Batra Pete S. , Tajudeen Bobby A.
Published: June 2020

Background

Smoking status has been established as a known irritant of the upper and lower respiratory tracts, leading to inflammation throughout the respiratory system. Tobacco smoking is one comorbidity encountered among chronic rhinosinusitis (CRS) patients. The histopathologic features of CRS and comorbid smoking status have yet to be determined by structured histopathology and may have important implications on disease management.

Methods

Retrospective study of structured histopathology reports analyzing sinus tissue removed during functional endoscopic sinus surgery. Histopathology variables were compared among patients with CRS who were reported as never smokers, former smokers, or current smokers.

Results

A total of 285 CRS patients were included: 173 never smokers, 85 former smokers, and 27 current smokers. When compared with former smokers, current smokers demonstrated increased basement membrane thickening (88.9% vs 67.1%, P <.020). Compared with never smokers, former and current smokers collectively demonstrated increased hyperplastic changes (14.3% vs 6.9%, P < .035), increased squamous metaplasia (26.8% vs 17.3%, P < .040), and trends toward increased basement membrane thickening (72.3% vs 65.3%, P < .124) and increased fibrosis (47.3% vs 40.5%, P < .154).

Conclusion

Smoking status may influence histopathologic tissue-level changes in CRS disease. Interestingly, former and current smokers maintained few differences in histopathology. However, former and current smokers collectively demonstrated increased chronic inflammatory changes compared with never smokers. These findings suggest that the timing of smoking exposure has limited effect on the tissue level, rather exposure overall influences inflammatory change. These findings may have important implications on medical and surgical management of CRS disease and comorbid smoking status.
Risk factors for peripherally inserted central catheter line–related deep venous thrombosis in critically ill intensive care unit patients
Authors: Bhargava M , Broccard S , Bai Y , Wu B , Dincer EH , Broccard A
Published: June 2020

Introduction:

Central venous access using peripherally inserted central catheters is frequently used for patients receiving intravenous medications in the hospital or outpatients. Although there are several benefits of peripherally inserted central catheters, such as ease of insertion, low procedure-related risk and higher patient satisfaction, there are complications associated with peripherally inserted central catheter use. Despite some studies evaluating peripherally inserted central catheter line–related complications, the factors associated with peripherally inserted central catheter–related deep venous thrombosis in critically ill medical-surgical patients are poorly described. The objective of this case-control study was to identify the risk factors associated with peripherally inserted central catheter line–related deep venous thrombosis in critically ill medical-surgical intensive care unit patients in a community hospital.

Methods:

We abstracted relevant clinical data from 21 cases with symptomatic peripherally inserted central catheter–related deep venous thrombosis and 42 controls with peripherally inserted central catheters but no deep venous thrombosis.

Results:

Of the factors evaluated, female gender, the use of triple lumen peripherally inserted central catheters, larger outer diameter, and open (vs valve) peripherally inserted central catheters were associated with venous thrombosis. In this retrospective study, we did not identify any association of peripherally inserted central catheter–related deep venous thrombosis with a prior history of deep venous thrombosis, use of alteplase, antiplatelet therapy, prophylactic or therapeutic anticoagulation, international normalized ratio, platelet count and the use of peripherally inserted central catheters for total parenteral nutrition.

Conclusion:

Our study indicates that the catheter size relative to the diameter of the vein could be an important risk factor for the development of peripherally inserted central catheter–related deep venous thrombosis. The study findings should be confirmed in a larger study designed to identify risk factors of peripherally inserted central catheter–related deep venous thrombosis. In the meantime, the peripherally inserted central catheter lines should be used judiciously in critically ill patients.
Hong Kong (in China) studies: Hong Kong popular culture as example
Authors: Chu Yiu-Wai
Published: June 2020

“China has become a predicament as well as a condition for Hong Kong culture” in the age of China, especially after the signing of the Closer Economic Partnership Agreement in 2003. This has become even more acute for Hong Kong culture in the integration of the Greater Bay Area, which can be seen as incorporating Hong Kong and Macao’s development into the overall development of the country. At this particular juncture, the issue of integration with the Mainland has become a topic that is of utmost importance for any consideration of the future of Hong Kong culture and the city as a whole. In this special context, the transmission of Hong Kong popular cultures in the Mainland are related topics that need to be explored. For example, what are the implications behind the success of Hong Kong directors and producers who took the helm of immensely popular Mainland television series? After Cantopop crossed the border, to what extent did the singers and the songs that they sang in Mainland music reality shows represent Hong Kong? These would be very good case studies of Hong Kong culture in cross-border ventures, and studying their transmissions would have long-term implications for not only Hong Kong culture in particular but also Hong Kong Studies in general. This essay endeavors to use these cross-border experiences as examples to offer a prolegomenon to Hong Kong (in China) Studies, which will in turn contribute to the possibility of generating a cultural studies response to the new configuration of the Greater Bay Area.
Understanding the vicarious trauma and emotional labour of criminological research
Authors: Moran Rebecca J , Asquith Nicole L
Published: June 2020

The psychological cost of exposure to traumatic events is receiving greater recognition in recent years, especially in terms of its impact in helping professions and emergency services. However, the costs to researchers remain relatively unexplored. In this article, we will discuss the nature and impact of vicarious trauma using two criminological research projects as case studies: one a qualitative project engaging with survivors of childhood sexual abuse, and the other, a quantitative analysis of police hate crime reports. In addition to considering the trauma elicited in fieldwork such as interviews, we interrogate the costs imposed on researchers during the coding and analysing processes. We suggest that the cost is potentially greater when the researcher has a personal connection with the issues being researched, but that this personal experience also provides the researcher with important skills for responding to new or compounded trauma. The costs of engagement with trauma may be compensated by the productive outputs and impact on policy and practice that this type of research may elicit. Understanding the impact and costs of engaging with close analyses of trauma is critical in developing more robust and ethical research processes to ensure that this trauma is appropriately managed so as to avert the long-term damage this work can inflict on researchers and participants.
Linguistic Borrowing and Translanguaging in Multicultural Obollo Speech Community, Southeastern Nigeria
Authors: Ugwuona Crescentia
Published: June 2020

Historically, the influx of people with different cultural and linguistic backgrounds (e.g., Onitsha, Hausa, Yoruba, and Idoma) in Nigeria to Obollo from 1970s onward led to language contact and its consequences on an unprecedented scale. The influx of people needs sociolinguistic awareness as they develop a complex mosaic of multiple communicative competences. In addition, the mass movement of people associated with globalization, business transactions, high rate of mobility of people, and their linguistic repertoire entails new sociolinguistic configuration of a type not previously experienced. This study therefore explores linguistic borrowing and translanguaging in the superdiverse Obollo region using translanguaging and linguistic borrowing theory. Data from Obollo through semi-unstructured oral interview and participial observation were analyzed descriptively. The article identifies core and cultural borrowing, code-meshing, and translanguaging. The study contributes to translanguaging and linguistic borrowing literature and provides relevant information for education and research into contemporary language use in multilingual contexts.
Randomized Controlled Trial Testing Mobile-Based Attention-Bias Modification for Posttraumatic Stress Using Personalized Word Stimuli
Authors: Niles Andrea N. , Woolley Joshua D. , Tripp Paige , Pesquita Ana , Vinogradov Sophia , Neylan Thomas C. , O’Donovan Aoife
Published: June 2020

Although behavioral therapies are effective for posttraumatic stress disorder (PTSD), access for patients is limited. Attention-bias modification (ABM), a cognitive-training intervention designed to reduce attention bias for threat, can be broadly disseminated using technology. We remotely tested an ABM mobile app for PTSD. Participants ( N = 689) were randomly assigned to personalized ABM, nonpersonalized ABM, or placebo training. ABM was a modified dot-probe paradigm delivered daily for 12 sessions. Personalized ABM included words selected using a recommender algorithm. Placebo included only neutral words. Primary outcomes (PTSD and anxiety) and secondary outcomes (depression and PTSD clusters) were collected at baseline, after training, and at 5-week-follow-up. Mechanisms assessed during treatment were attention bias and self-reported threat sensitivity. No group differences emerged on outcomes or attention bias. Nonpersonalized ABM showed greater declines in self-reported threat sensitivity than placebo ( p = .044). This study constitutes the largest mobile-based trial of ABM to date. Findings do not support the effectiveness of mobile ABM for PTSD.
COVID-19 and Acute Lupus Pneumonitis: Diagnostic and Treatment Dilemma
Authors: Kichloo Asim , Aljadah Michael , Albosta Michael , Wani Farah , Singh Jagmeet , Solanki Shantanu
Published: June 2020

In this article, we present a case of a young female patient with previously diagnosed lupus pneumonitis, now with a flare and new superimposed COVID-19 infection that was treated with intravenous steroids. On computed tomography scans, she had extensive interstitial lung fibrosis in addition to a positive COVID-19 polymerase chain reaction test requiring 6 L of oxygen via nasal cannula on admission. After administration of methylprednisolone, the patient improved and was weaned off her oxygen requirements and was discharged home.
Dynamic Dalmia: Can They Do it Again?
Authors: Kumar Rohit , Shukla Arun Kumar
Published: June 2020

This case study is about Dalmia Cement which is one of the oldest cement companies in India, established in the year 1939. In early 2000s, the company started its journey of aggressive growth under the leadership of young promoter-cum-managing director. The company has been one of the best performing companies in Indias in the last decade and being valued as one of the most valuable scrips of the stock market. The company has grown organically as well as inorganically by meticulously executing strategies of mergers and acquisitions and forging strategic alliances to spur the growth. While the company has a clear growth strategy for the future, it needs to find ways of going forward to ensure it traverses on the same growth path as it has done before.
High sensitivity C-reactive protein and risk of migraine in a 11-year follow-up with data from the Nord-Trøndelag health surveys 2006–2008 and 2017–2019
Authors: Hagen Knut , Stovner Lars Jacob , Zwart John-Anker
Published: June 2020

Background

Several previous studies have reported a cross-sectional association between elevated high sensitivity C-reactive protein (hs-CRP) and migraine. The aim of this population-based follow-up study was to investigate the influence of hs-CRP at baseline on the risk of developing migraine 11 years later.

Methods

Data from the Nord-Trøndelag Health Study performed in 2006–2008 (baseline) and 2017–2019 were used. A total of 19,574 participants without migraine at baseline were divided into three groups based on hs-CRP levels (< 3 mg/L, 3–9.99 mg/L and 10.00–20 mg/L). Poisson regression was used to evaluate the associations between hs-CRP levels and risk ratios (RRs) of migraine, and precision of the estimates was assessed by 95% confidence interval (CIs).

Results

In the multi-adjusted model, increased risk of migraine (RR 1.46, 95% CI 1.05–2.04) was found in the highest hs-CRP levels group compared to the lowest group. In the group with the highest hs-CRP levels, a nearly three times higher risk of chronic migraine (RR 2.81, 95% CI 1.12–7.06) was found, whereas no evident relationship was found between high hs-CRP level and risk of developing episodic migraine.

Conclusions

The main finding in this 11-year follow-up was that hs-CRP levels between 10.00–20.00 mg/L at baseline was associated with increased risk of chronic migraine.
Assistant diagnosis with Chinese electronic medical records based on CNN and BiLSTM with phrase-level and word-level attentions
Authors: Wang Tong , Xuan Ping , Liu Zonglin , Zhang Tiangang
Published: June 2020

Background

Inferring diseases related to the patient’s electronic medical records (EMRs) is of great significance for assisting doctor diagnosis. Several recent prediction methods have shown that deep learning-based methods can learn the deep and complex information contained in EMRs. However, they do not consider the discriminative contributions of different phrases and words. Moreover, local information and context information of EMRs should be deeply integrated.

Results

A new method based on the fusion of a convolutional neural network (CNN) and bidirectional long short-term memory (BiLSTM) with attention mechanisms is proposed for predicting a disease related to a given EMR, and it is referred to as FCNBLA. FCNBLA deeply integrates local information, context information of the word sequence and more informative phrases and words. A novel framework based on deep learning is developed to learn the local representation, the context representation and the combination representation. The left side of the framework is constructed based on CNN to learn the local representation of adjacent words. The right side of the framework based on BiLSTM focuses on learning the context representation of the word sequence. Not all phrases and words contribute equally to the representation of an EMR meaning. Therefore, we establish the attention mechanisms at the phrase level and word level, and the middle module of the framework learns the combination representation of the enhanced phrases and words. The macro average f-score and accuracy of FCNBLA achieved 91.29 and 92.78%, respectively.

Conclusion

The experimental results indicate that FCNBLA yields superior performance compared with several state-of-the-art methods. The attention mechanisms and combination representations are also confirmed to be helpful for improving FCNBLA’s prediction performance. Our method is helpful for assisting doctors in diagnosing diseases in patients.
New haplochromine cichlid from the upper Miocene (9–10 MYA) of Central Kenya
Authors: Altner Melanie , Ruthensteiner Bernhard , Reichenbacher Bettina
Published: June 2020

Background

The diversification process known as the Lake Tanganyika Radiation has given rise to the most speciose clade of African cichlids. Almost all cichlid species found in the lakes Tanganyika, Malawi and Victoria, comprising a total of 12–16 tribes, belong to this clade. Strikingly, all the species in the latter two lakes are members of the tribe Haplochromini, whose origin remains unclear. The ‘out of Tanganyika’ hypothesis argues that the Haplochromini emerged simultaneously with other cichlid tribes and lineages in Lake Tanganyika, presumably about 5–6 million years ago (MYA), and that their presence in the lakes Malawi and Victoria and elsewhere in Africa today is due to later migrations. In contrast, the ‘melting pot Tanganyika hypothesis’ postulates that Haplochromini emerged in Africa prior to the formation of Lake Tanganyika, and that their divergence could have begun about 17 MYA. Haplochromine fossils could potentially resolve this debate, but such fossils are extremely rare.

Results

Here we present a new fossil haplochromine from the upper Miocene site Waril (9–10 million years) in Central Kenya. Comparative morphology, supported by Micro-CT imaging, reveals that it bears a unique combination of characters relating to dentition, cranial bones, caudal skeleton and meristic traits. Its most prominent feature is the presence of exclusively unicuspid teeth, with canines in the outer tooth row. †Warilochromis unicuspidatusgen. et sp. nov. shares this combination of characters solely with members of the Haplochromini and its lacrimal morphology indicates a possible relation to the riverine genusPseudocrenilabrus. Due to its fang-like dentition and non-fusiform body, †W. unicuspidatusgen. et sp. nov. might have employed either a sit-and-pursue or sit-and-wait hunting strategy, which has not been reported for any other fossil haplochromine cichlid.

Conclusions

The age of the fossil (9–10 MYA) is incompatible with the ‘out of Tanganyika’ hypothesis, which postulates that the divergence of the Haplochromini began only 5–6 MYA. The presence of this fossil in an upper Miocene palaeolake in the Central Kenya Rift, as well as its predatory lifestyle, indicate that Haplochromini were already an important component of freshwater drainages in East Africa at that time.
Evolutionary significance of amino acid permease transporters in 17 plants from Chlorophyta to Angiospermae
Authors: Zhang Chao , Kong Nana , Cao Minxuan , Wang Dongdong , Chen Yue , Chen Qin
Published: June 2020

Background

Nitrogen is an indispensable nutrient for plant growth. It is used and transported in the form of amino acids in living organisms. Transporting amino acids to various parts of plants requires relevant transport proteins, such as amino acid permeases (AAPs), which were our focus in this study.

Results

We found that 5 AAP genes were present in Chlorophyte species and more AAP genes were predicted in Bryophyta and Lycophytes. Two main groups were defined and group I comprised 5 clades. Our phylogenetic analysis indicated that the origin of clades 2, 3, and 4 is Gymnospermae and that these clades are closely related. The members of clade 1 included Chlorophyta to Gymnospermae. Group II, as a new branch consisting of non-seed plants, is first proposed in our research. Our results also indicated that the AAP family was already present in Chlorophyta and then expanded accompanying the development of vasculature. Concurrently, the AAP family experienced multiple duplication events that promoted the generation of new functions and differentiation of sub-functions.

Conclusions

Our findings suggest that the AAP gene originated in Chlorophyta, and some non-seed AAP genes clustered in one group. A second group, which contained plants of all evolutionary stages, indicated the evolution of AAPs. These new findings can be used to guide future research.
Progranulin inhibits LPS-induced macrophage M1 polarization via NF-кB and MAPK pathways
Authors: Liu Lianlian , Guo Hongmei , Song Aimei , Huang Jiahui , Zhang Yu , Jin Shanshan , Li Shutong , Zhang Liguo , Yang Chengzhe , Yang Pishan
Published: June 2020

Background

Macrophage M1 polarization plays a pivotal role in inflammatory diseases. Progranulin (PGRN) has potential anti-inflammation action, however, the effect of PGRN on macrophage M1 polarization has been poorly studied. Our study aimed to investigate the effect of PGRN on lipopolysaccharide (LPS)-induced macrophage M1 polarization and clarify the underlying mechanisms.

Methods

RAW264.7 cells were polarized to M1 macrophage by LPS with or without recombinant PGRN (rPGRN) and tumor necrosis factor alpha antibody (anti-TNF-α). A cell counting kit-8 assay (CCK-8), flow cytometry, Quantitative Real-Time PCR assay (q-PCR), Western blot assay and enzyme-linked immunosorbent assay (ELISA) were used to determine the effect of different treatments on cell proliferation, expression of surface phenotype marker and expressions and secretion of inflammatory cytokines. The activation of NF-κB/mitogen-activated protein kinase (MAPK) pathways and the nuclear translocation of NF-κB p65 were detected by Western blot and immunofluorescence respectively. THP-1 and primary bone marrow-derived monocytes (BMDMs) were also used to demonstrate effect of PGRN on expressions and secretion of inflammatory cytokines induced by LPS.

Results

In RAW264.7 cells, rPGRN at concentrations below 80 ng/ml significantly promoted cell proliferation in dose dependent fashion. rPGRN significantly inhibited LPS-induced change of phenotype (CD86/CD206 ratio) and function (tumor necrosis factor (TNF-α) and inducible nitric oxide synthase (iNOS) expressions). LPS-stimulated secretion of TNF-α and activated phosphorylation of IKKα/β, IкBα, p65, JNK and p38 and the nucleus translocation of NF-кB p65 were also significantly downregulated by rPGRN. In addition, recombinant TNF-α (rTNF-α) significantly boosted TNF-α and iNOS expression vs the control group. Moreover, anti-TNF-α significantly inhibited LPS-induced TNF-α and iNOS expression. In THP-1 and BMDM cells, reversing effect of rPGRN on LPS-enhanced expressions of TNF-α and iNOS and secretion of TNF-α was further demonstrated.

Conclusions

PGRN down-regulates LPS-induced macrophage M1 polarization in phenotype and function via NF-κB/MAPK signaling pathways.
MYB44 competitively inhibits the formation of the MYB340-bHLH2-NAC56 complex to regulate anthocyanin biosynthesis in purple-fleshed sweet potato
Authors: Wei Zeng-Zheng , Hu Kang-Di , Zhao Dong-Lan , Tang Jun , Huang Zhong-Qin , Jin Peng , Li Yan-Hong , Han Zhuo , Hu Lan-Ying , Yao Gai-Fang , Zhang Hua
Published: June 2020

Background

Anthocyanins, which have important biological functions and have a beneficial effect on human health, notably account for pigmentation in purple-fleshed sweet potato tuberous roots. Individual regulatory factors of anthocyanin biosynthesis have been identified; however, the regulatory network of anthocyanin biosynthesis in purple-fleshed sweet potato is unclear.

Results

We functionally determined that IbMYB340 cotransformed with IbbHLH2 in tobacco and strawberry receptacles induced anthocyanin accumulation, and the addition of IbNAC56a or IbNAC56b caused increased pigmentation. Furthermore, we confirmed the interaction of IbMYB340 with IbbHLH2 and IbNAC56a or IbNAC56b via yeast two-hybrid and firefly luciferase complementation assays; these proteins could form a MYB340-bHLH2-NAC56a or MYB340-bHLH2-NAC56b transcriptional complex to regulate anthocyanin biosynthesis by binding to the IbANS promoter rather than the IbUFGT promoter. Furthermore, it was found by a transient expression system in tobacco leaves that IbMYB44 could decrease anthocyanin accumulation. Moreover, the interaction of IbMYB44 with IbMYB340 and IbNAC56a or IbNAC56b was verified. This result suggested that IbMYB44 acts as a repressor of anthocyanin in sweet potato.

Conclusions

The repressor IbMYB44 affected anthocyanin biosynthesis by competitively inhibiting the IbMYB340-IbbHLH2-IbNAC56a or IbMYB340-IbbHLH2-IbNAC56b regulatory complex formation. Overall, the present study proposed a novel regulatory network whereby several vital TFs play key roles in regulating anthocyanin biosynthesis, and it provides strong insight into the potential mechanism underlying anthocyanin biosynthesis in sweet potato tuberous roots with purple color.
Visfatin associated with major adverse cardiovascular events in patients with acute myocardial infarction
Authors: Zheng Meifan , Lu Nan , Ren Meixia , Chen Haifeng
Published: June 2020

Background

Visfatin is an adipokine that related with the inflammation in atherosclerosis and the destabilization of atherosclerotic plaque. The aim of this study was to observe the relationship between visfatin and major adverse cardiovascular events (MACEs) in acute myocardial infarction (AMI) patients.

Methods

We enrolled a total of 238 patients (183 AMI and 55 control) who underwent coronary angiography. Patients with AMI were followed for an average of 19.3 months and 159 patients were finally included in the study.

Results

It was observed patients with AMI had higher serum visfatin levels than controls. The total incidence of MACEs was 11.32% (18/159) in AMI patients. After calculation of the Youden index, the best cut-off value of visfatin on the curve of receiver-operating characteristic was 8.799 ng/mL for predicting the occurrence of MACEs. The occurrence of MACEs was elevated in high-visfatin group (≥8.799 ng/mL) compared with low-visfatin group (≤8.799 ng/mL). The time to MACEs was correlated with visfatin (HR = 1.235, 95%CI 1.051–1.451, P = 0.01) and high-visfatin group had an earlier time to MACEs and a shorter time of cumulative survival.

Conclusions

Increased serum visfatin levels were observed in AMI patients, and correlated with an earlier onset and higher incidence of MACEs.