bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimal fractionation and timing of weekly cone-beam CT in daily surface-guided radiotherapy for breast cancer
Authors: Peng Haiyan , Yang Han , Lei Jinyan , Dai Xinyao , Cao Panpan , Jin Fu , Luo Huanli
Published: July 2023

Purpose

Surface-guided radiotherapy (SGRT) has been demonstrated to be a promising supplement to cone-beam computed tomography (CBCT) in adjuvant breast cancer radiotherapy, but a rational combination mode is lacking in clinical practice. The aim of this study was to explore this mode and investigate its impact on the setup and dose accuracy.

Methods and materials

Daily SGRT and weekly CBCT images were acquired for 23 patients with breast cancer who received conventional fractionated radiotherapy after lumpectomy. Sixteen modes were acquired by randomly selecting one (CBCT1), two (CBCTij), three (CBCTijk), four (CBCTijkl), and five (CBCT12345) images from the CBCT images for fusion with the SGRT. The CTV-PTV margins, OAR doses, and dose coverage (V95%) of PTV and CTV was calculated based on SGRT setup errors with different regions of interest (ROIs). Dose correlations between these modalities were investigated using Pearson and Spearman’s methods. Patient-specific parameters were recorded to assess their impact on dose.

Results

The CTV-PTV margins decreased with increasing CBCT frequencies and were close to 5 mm for CBCTijkl and CBCT12345. For the ipsilateral breast ROI, SGRT errors were larger in the AP direction, and target doses were higher in all modes than in the whole breast ROI (P < 0.05). In the ipsilateral ROI, the target dose correlations between all modes increased with increasing CBCT time intervals, decreased, and then increased with increasing CBCT frequencies, with the inflection point being CBCT participation at week 5. The dose deviations in CBCT123, CBCT124, CBCT125, CBCTijkl, and CBCT12345 were minimal and did not differ significantly (P > 0.05). There was excellent agreement between CBCT124 and CBCT1234, and between (CBCTijkl, CBCT12345) and CBCT125 in determining the classification for the percentage of PTV deviation (Kappa = 0.704–0.901). In addition, there were weak correlations between the patient’s Dips_b (ipsilateral breast diameter with bolus) and CTV doses in modes with CBCT participation at week 4 (R = 0.270 to 0.480).

Conclusions

Based on weekly CBCT, these modes with ipsilateral ROI and a combination of daily SGRT and a CBCT frequency of ≥ 3 were recommended, and CBCT was required at weeks 1 and 2 for CBCTijk.
Effectiveness of the Gratuité user fee exemption policy on utilization and outcomes of maternal, newborn and child health services in conflict-affected districts of Burkina Faso from 2013 to 2018: a pre-post analysis
Authors: Offosse Marie-Jeanne , Avoka Cephas , Yameogo Pierre , Manli Astrid Raissa , Goumbri Aude , Eboreime Ejemai , Boxshall Matt , Banke-Thomas Aduragbemi
Published: July 2023

Background

Evidence on effectiveness of user fee exemption policies targeting maternal, newborn, and child health (MNCH) services is limited for conflict-affected settings. In Burkina Faso, a country that has had its fair share of conflicts, user fee exemption policies have been piloted since 2008 and implemented along with a national government-led user fee reduction policy (‘SONU’: Soins Obstétricaux et Néonataux d'Urgence). In 2016, the government transitioned the entire country to a user fee exemption policy known as Gratuité. Our study objective was to assess the effect of the policy on the utilization and outcomes of MNCH services in conflict-affected districts of Burkina Faso.

Methods

We conducted a quasi-experimental study comparing four conflict-affected districts which had the user fee exemption pilot along with SONU before transitioning to Gratuité (comparator) with four other districts with similar characteristics, which had only SONU before transitioning (intervention). A difference-in-difference approach was initiated using data from 42 months before and 30 months after implementation. Specifically, we compared utilization rates for MNCH services, including antenatal care (ANC), facility delivery, postnatal care (PNC) and consultation for malaria. We reported the coefficient, including a 95% confidence interval (CI), p value, and the parallel trends test.

Results

Gratuité led to significant increases in rates of 6th day PNC visits for women (Coeff 0.15; 95% CI 0.01–0.29), new consultations in children < 1 year (Coeff 1.80; 95% CI 1.13–2.47, p < 0.001), new consultations in children 1–4 years (Coeff 0.81; 95% CI 0.50–1.13, p = 0.001), and uncomplicated malaria cases treated in children < 5 years (Coeff 0.59; 95% CI 0.44–0.73, p < 0.001). Other service utilization indicators investigated, including ANC1 and ANC5+ rates, did not show any statistically significant positive upward trend. Also, the rates of facility delivery, 6th hour and 6th week postnatal visits were found to have increased more in intervention areas compared to control areas, but these were not statistically significant.

Conclusions

Our study shows that, even in conflict-affected areas, the Gratuité policy significantly influences MNCH service utilization. There is a strong case for continued funding of the user fee exemption policy to ensure that gains are not reversed, especially if the conflict ceases to abate.
HiCognition: a visual exploration and hypothesis testing tool for 3D genomics
Authors: Langer Christoph C. H. , Mitter Michael , Stocsits Roman R. , Gerlich Daniel W.
Published: July 2023

Genome browsers facilitate integrated analysis of multiple genomics datasets yet visualize only a few regions at a time and lack statistical functions for extracting meaningful information. We present HiCognition, a visual exploration and machine-learning tool based on a new genomic region set concept, enabling detection of patterns and associations between 3D chromosome conformation and collections of 1D genomics profiles of any type. By revealing how transcription and cohesion subunit isoforms contribute to chromosome conformation, we showcase how the flexible user interface and machine learning tools of HiCognition help to understand the relationship between the structure and function of the genome.
Alterations in the hepatocyte epigenetic landscape in steatosis
Authors: Maji Ranjan Kumar , Czepukojc Beate , Scherer Michael , Tierling Sascha , Cadenas Cristina , Gianmoena Kathrin , Gasparoni Nina , Nordström Karl , Gasparoni Gilles , Laggai Stephan , Yang Xinyi , Sinha Anupam , Ebert Peter , Falk-Paulsen Maren , Kinkley Sarah , Hoppstädter Jessica , Chung Ho-Ryun , Rosenstiel Philip , Hengstler Jan G. , Walter Jörn , Schulz Marcel H. , Kessler Sonja M. , Kiemer Alexandra K.
Published: July 2023

Fatty liver disease or the accumulation of fat in the liver, has been reported to affect the global population. This comes with an increased risk for the development of fibrosis, cirrhosis, and hepatocellular carcinoma. Yet, little is known about the effects of a diet containing high fat and alcohol towards epigenetic aging, with respect to changes in transcriptional and epigenomic profiles. In this study, we took up a multi-omics approach and integrated gene expression, methylation signals, and chromatin signals to study the epigenomic effects of a high-fat and alcohol-containing diet on mouse hepatocytes. We identified four relevant gene network clusters that were associated with relevant pathways that promote steatosis. Using a machine learning approach, we predict specific transcription factors that might be responsible to modulate the functionally relevant clusters. Finally, we discover four additional CpG loci and validate aging-related differential CpG methylation. Differential CpG methylation linked to aging showed minimal overlap with altered methylation in steatosis.
Remote cardiac rehabilitation program during the COVID-19 pandemic for patients with stable coronary artery disease after percutaneous coronary intervention: a prospective cohort study
Authors: Gu Junjie , Tong Xiaoshan , Meng Shasha , Xu Shuhui , Huang Jinyan
Published: July 2023

Objective

The coronavirus disease-19 (COVID-19) pandemic restricts rapid implementation of in-person delivery of cardiac rehabilitation (CR) at the center for coronary artery disease (CAD) patients undergoing percutaneous coronary intervention (PCI), thus enabling a cohort comparison of in-person vs. remote CR program. This study aims to investigate outcomes of exercise capacity, health-related quality of life (HRQL), mental health, and family burden of stable CAD patients undergoing PCI in low-to-moderate risk after different delivery models of CR program.

Methods

The study included a cohort of stable CAD patients undergoing PCI who had experienced two naturally occurring modes of CR program after hospital discharge at two time periods, January 2019 to December 2019 (in-person CR program) and May 2020 to May 2021 (remote CR program). The exercise capacity was assessed by means of 6-min walk test (6MWT), maximal oxygen uptake (VO2max) and the respiratory anaerobic threshold (VO2AT) before discharge, at the end of the 8-week and 12-week in-person or remote CR program after discharge.

Results

No adverse events occurred during the CR period. CAD patients had a longer distance walked in 6 min with a higher VO2max after 8-week and 12-week CR program whether in-person or remote model (p < 0.05). The distance walked in 6 min was longer and the maximal oxygen uptake (VO2max) was higher at the end of the 12-week in-person or remote CR program than 8-week in-person or remote CR program (p < 0.05). The respiratory anaerobic threshold (VO2AT) of CAD patients was decreased after 8-week CR program whether in-person or remote model (p < 0.05). CAD patients receiving remote CR program exhibited higher HRQL scores in domains of vitality (p = 0.048), role emotional (p = 0.039), mental health (p = 0.014), and the summary score of the mental composite (p = 0.048) compared to in-person CR program after 8 weeks. The anxiety and depression scores of CAD patients undergoing PCI were decreased after 8-week CR program whether in-person or remote model (p < 0.05). The CAD patients receiving remote delivery showed lower anxiety and depression scores compared to those receiving in-person delivery at the end of the 8-week CR program (p < 0.05). It was found that the family burden scores of CAD patients undergoing PCI were reduced after 8-week and 12-week CR program whether in-person or remote model (p < 0.05). The CAD patients receiving remote CR program showed lower family burden scores than those receiving in-person CR program after whether 8 weeks or 12 weeks (p < 0.05).

Conclusion

These data indicate that a properly designed and monitored remote delivery represents a feasible and safe model for low-to-moderate-risk, stable CAD patients undergoing PCI inaccessible to in-person CR during the COVID-19 pandemic.
CTLA4 DNA methylation is associated with CTLA-4 expression and predicts response to immunotherapy in head and neck squamous cell carcinoma
Authors: Hoffmann Friederike , Franzen Alina , de Vos Luka , Wuest Lennert , Kulcsár Zsófi , Fietz Simon , Maas Alexander Philippe , Hollick Sarah , Diop Marie Yatou , Gabrielpillai Jennis , Vogt Timo , Kuster Pia , Zarbl Romina , Dietrich Joern , Kristiansen Glen , Brossart Peter , Landsberg Jennifer , Strieth Sebastian , Dietrich Dimo
Published: July 2023

Background

The majority of patients with recurrent or metastasized head and neck squamous cell carcinoma (HNSCC) do not benefit from immune checkpoint blockade (ICB) while several patients experience severe and persistent immune-mediated side effects. Therefore, predictive biomarkers are urgently needed to allow for a personalized treatment. In this study, we investigated DNA methylation of the immune checkpoint gene CTLA4 with regard to its predictive value.

Methods

We analyzed CTLA4 promoter methylation in tumors of HNSCC patients (N = 29) treated with ICB at the University Medical Center Bonn with regard to response to ICB and progression-free survival. We further analyzed a second cohort (N = 138) of patients that did not receive ICB with regard to CTLA4 promoter methylation, CTLA-4 protein expression, and immune cell infiltrates. Finally, we tested inducibility of CTLA-4 protein expression in HNSCC cells using the DNA methyltransferase inhibitor decitabine.

Results

Lower CTLA4 promoter methylation correlated with response to ICB and prolonged progression-free survival. We could show that not only tumor infiltrating immune cells, but also HNSCC cells harbor cytoplasmic and nuclear CTLA-4 expression. CTLA4 promoter methylation inversely correlated with infiltrates of CD3+, CD4+, CD8+, and CD45+ immune cells. CTLA4 methylation did not correlate with protein expression in tumors, however, decitabine treatment led to decreased CTLA4 methylation and an induction of CTLA4 mRNA and CTLA-4 protein expression in HNSCC cell lines.

Conclusions

Our results indicate that CTLA4 DNA hypomethylation is a predictive biomarker for response to ICB in HNSCC. Our study warrants further analyses of the predictive value of CTLA4 DNA methylation in clinical trials of anti-PD-1 and/or anti-CTLA-4 immunotherapy in HNSCC.
MRI of endometriosis in correlation with the #Enzian classification: applicability and structured report
Authors: Maciel Cristina , Ferreira Hélder , Djokovic Dusan , Kyaw Tun Jimmy , Keckstein Jörg , Rizzo Stefania , Manganaro Lucia
Published: July 2023

Endometriosis represents one of the most common causes of life-impacting chronic pelvic pain and female infertility. Magnetic resonance imaging (MRI) plays an increasing role in the diagnosis and mapping of endometriosis, while diagnostic laparoscopy currently tends to be reserved for the patients with negative imaging results. The #Enzian, published in 2021, proposes a new comprehensive classification system of endometriosis, combining a complete staging of deep infiltrative endometriosis with the evaluation of peritoneal/ovarian/tubal localizations and the presence of adenomyosis. This article addresses in detail the applicability of the #Enzian classification, primarily based on surgical findings, to the MRI evaluation of the endometriosis. Overall, there is a significant matching between MRI features and the #Enzian classification criteria, two different perspectives of endometriosis mapping, with different goals and levels of detail. The main discrepancy lies in the evaluation of tubo-ovarian condition, which is not fully assessable by MRI. Furthermore, as endometriosis is a complex disease, usually multifocal, that can present with a myriad of imaging findings, MRI reporting should be clear and well organized. The authors group, both radiologists and gynecologists, propose a structured MRI report of endometriosis in correlation with the #Enzian classification, merging the detailed anatomical and pre-operative information provided by the MRI with the benefits of a comprehensive classification system of endometriosis in the clinical practice and research field.

Critical relevance statement This article addresses in detail the applicability of the #Enzian classification, primarily based on surgical findings, to the MRI evaluation of the endometriosis and proposes a #Enzian-based structured MRI report.

Graphical abstract
Self-healing of type B acute aortic dissection after aortic valve replacement: a case report
Authors: Jiang Ling , Xie Xiangrong , Wei Jun
Published: July 2023

Background

As a life-threatening and serious condition, aortic dissection (AD) is divided into type A and B according to its association with the ascending or descending aorta. Type A AD is often accompanied by aortic regurgitation, while type B dissections are rarely accompanied by severe aortic regurgitation.

Case presentation

We present a 71 year-old Chinese man with a rare case of type B AD with severe aortic insufficiency, who self-healed after 1 year of an aortic valve replacement. He complained of chest tightness and abdominal pain. Due to poor cardiac function, he underwent aortic valve replacement before intervening on the dissection. The operation was successful, and the dissection was treated conservatively. During the 1-year follow-up, his chest tightness improved, and the type B dissection was healed. His general condition is considerably improved.

Conclusions

In type B AD combined with severe aortic insufficiency, aortic valve replacement should be prioritized. This is potentially explained by the aortic root activity and pulse pressure difference.
Frequency of significant virulence genes in gastric biopsies of Helicobacter pylori-positive patients with gastritis
Authors: Gholamhosseinzadeh Ebrahim , Ghalehnoei Hossein , Kazemi Veisari Arash , Sheidaei Somayeh , Goli Hamid Reza
Published: July 2023

Helicobacter pylori is one of the most common bacteria affecting human societies worldwide, and is mainly associated with gastrointestinal complications due to different virulence factors. This study aimed to investigate some virulence genes of H. pylori in gastric biopsies of patients with gastritis in Sari city, North of Iran. Informed consent forms were obtained from the studied patients, and those who needed endoscopy were included in the study. To evaluate the prevalence of cagA, iceA1, iceA2, vacA, dupA, and oipA genes, gastric biopsies with positive or negative rapid urease test were collected from 50 patients (25 in each group) with gastro-duodenal diseases. The bacterial DNAs were extracted by a specific kit, and the presence of the genes was analyzed by PCR using specific primers. Eighteen (72%) biopsies from 25 H. pylori-positive samples were cagA-positive, while 17 (68%) biopsies contained the vacA gene, and 11 (44%) samples had both vacA and cagA genes. However, 16 (64%), 12 (48%), 13 (52%), and 14 (56%) biopsies contained dupA, iceA1, iceA2, and oipA genes, respectively. Due to the significant role of the studied virulence factors in the pathogenicity of H. pylori, the high prevalence of these factors in biopsies of patients with gastritis is a concern needing to the management in this region.
High out‑of‑pocket spending and financial hardship at the end of life among cancer survivors and their families
Authors: Zhao Jingxuan , Yabroff K. Robin
Published: July 2023

Cancer is one of the most expensive medical conditions to treat worldwide, affecting national and local spending, as well as household budgets for patients and their families. In this commentary about a recent paper from Tur‑Sinai et al., we discuss the high out-of-pocket spending and medical and non-medical financial hardship faced by cancer patients and their families at the end-of-life in Israel. We provide recent information about the costs of health care in Israel and other high-income countries with (i.e., Canada, Australia, Japan, and Italy) and without universal health insurance coverage (i.e., United States, a country with high healthcare costs and uninsurance rate), and highlight the role of improving health insurance coverage and benefit design in reducing financial hardship among cancer patients and their families. Recognizing that financial hardship at the end of life affects both patients and their families, developing comprehensive programs and policies in Israel as well as in other countries is warranted.
Agroforestry-based community forestry as a large-scale strategy to reforest agricultural encroachment areas in Myanmar: ambition vs. local reality
Authors: San Su Mon , Kumar Navneet , Biber-Freudenberger Lisa , Schmitt Christine B.
Published: July 2023

Key message

The Forest Department strongly influences agroforestry design, tree species selection, and the participation and motivation of farmers to plant trees. Farmers perceive trees as harmful to crops and have avoided planting them near crops. We recommend considering farmers’ preferences, establishing farmers’ field schools, and increasing their awareness about the benefits of trees to improve adoption rates of agroforestry systems.

Context

The high rate of deforestation in Myanmar is mainly due to agricultural expansion. One task of the Forest Department is to increase tree cover in the agricultural encroachment areas by establishing large-scale agroforestry-based community forests (ACFs).

Aim

The objectives of this study were to analyze the adoption and performance of the ACFs in the agricultural encroachment areas in the Bago-Yoma Region, Myanmar; and to provide recommendations to enhance the adoption of ACFs by farmers.

Methods

We inventoried 42 sample plots and surveyed 291 farmers. Survey responses were analyzed by binary logistic regression, one-way ANOVA, and non-parametric correlation tests to evaluate factors influencing the adoption of ACFs. Stand characteristics were calculated from the inventory data to evaluate the performance of ACFs.

Results

Our results show that farmer participation in ACFs was lower than stated in the registry of the Forest Department. Farmers practiced four different agroforestry designs in ACFs with different outcomes. The Forest Department strongly determined tree species and planting designs, farmers’ perception and participation in ACFs. Farmland size, unclear, and insufficient information on ACFs, and a negative perception of raising trees in crop fields were the major factors limiting the adoption rates of ACFs.

Conclusion

We recommend capacity building for farmers and Forest Department staff and raising awareness about the benefits of planting designs and trees on farmland. A stronger consideration of farmers’ preferences for design and species selection could increase their motivation to adopt ACFs and improve the long-term sustainability of ACFs.
Use of community resources as health assets for rehabilitation of people with Long COVID in northeastern Spain two years after the outbreak of the COVID-19 pandemic: qualitative study
Authors: Samper-Pardo Mario , Formento-Marín Natalia , Oliván-Blázquez Bárbara , León-Herrera Sandra , Benedé-Azagra Belén
Published: July 2023

Introduction

The epidemiology of Post COVID Condition is not yet known. There are different treatment options, but they are not recommended or suitable for all those affected. For this reason and due to the lack of health treatment, many of these patients have tried to carry out their own rehabilitation through the use of community resources.

Objective

The objective of this study is to deepen into the understanding about the use of community resources as assets for health and rehabilitation by people with Long COVID and their utility.

Methodology

A qualitative design was carried out with the participation of 35 Long COVID patients, of which 17 subjects were interviewed individually and 18 of them were part of two focus groups. The participating patients were recruited in November and December 2021 from the Primary Health Care centers and through the Association of Long COVID patients of Aragon. The research topics were the use of community resources, before and after their infection by COVID-19, rehabilitation through their use, as well as barriers and strengths for their employment. All analyses were performed iteratively using NVivo software.

Results

Long COVID patients who have used community resources for rehabilitation have seen an improvement in their physical and mental health. Most of them, specifically those affected, have used green spaces, public facilities, physical or cultural activities and associations. The main barriers identified have been the symptoms themselves and the fear of reinfection, with the main advantage of these activities being the perceived health benefits.

Conclusion

The use of community resources seems to be beneficial in the recovery process of Long COVID patients, so it is necessary to continue delving into this topic and promote the formal use of the Recommendation of Health Assets from Primary healthcare.
Comparisons of perioperative and long-term outcomes of laparoscopic versus open gastrectomy for advanced gastric cancer after neoadjuvant therapy: an updated pooled analysis of eighteen studies
Authors: Pang Hua-Yang , Chen Xiu-Feng , Chen Li-Hui , Yan Meng-Hua , Chen Zhi-Xiong , Sun Hao
Published: July 2023

Background

Outcomes of laparoscopic surgery in advanced gastric cancer patients who received neoadjuvant therapy represent a controversial issue. We performed an updated meta-analysis to evaluate the perioperative and long-term survival outcomes of laparoscopic gastrectomy (LG) versus conventional open gastrectomy (OG) in this subset of patients.

Methods

Electronic databases including PubMed, Embase, Web of Science, the Cochrane Central Register of Controlled Trials and China National Knowledge Infrastructure were comprehensively searched up to May 2023. The short-term and long-term outcomes of LG versus OG in advanced gastric cancer patients undergoing neoadjuvant therapy were evaluated. Effect sizes with 95% confidence intervals were always assessed using random-effects model. The prospective protocol was registered with PROSPERO (CRD42022359126).

Results

Eighteen studies (2 randomized controlled trials and 16 cohort studies) involving 2096 patients were included. In total, 933 patients were treated with LG and 1163 patients were treated with OG. In perioperative outcomes, LG was associated with less estimated blood loss (MD = − 65.15; P < 0.0001), faster time to flatus (MD = − 0.56; P < 0.0001) and liquid intake (MD = − 0.42; P = 0.02), reduced hospital stay (MD = − 2.26; P < 0.0001), lower overall complication rate (OR = 0.70; P = 0.002) and lower minor complication rate (OR = 0.69; P = 0.006), while longer operative time (MD = 25.98; P < 0.0001). There were no significant differences between the two groups in terms of proximal margin, distal margin, R1/R2 resection rate, retrieved lymph nodes, time to remove gastric tube and drainage tube, major complications and other specific complications. In survival outcomes, LG and OG were not significantly different in overall survival, disease-free survival and recurrence-free survival.

Conclusion

LG can be a safe and feasible technique for the treatment of advanced gastric cancer patients receiving neoadjuvant therapy. However, more high-quality randomized controlled trials are still needed to further validate the results of our study.
Morphology and Morphometry of the Magellanic Penguin (Spheniscus magellanicus) Trachea
Authors: Birck Arlei José , Bernardi Amanda , Silva Andressa Aparecida , Silva Paulo Henrique Sampaio da , De lima Eduardo Mauricio mendes , Barreto-Vianna André Rodrigues da Cunha
Published: July 2023

Objective: This work aimed to describe the trachea of the Magellanic Penguin (Spheniscus magellanicus) through descriptive and morphometric approaches. Methods: ten adult male Spheniscus magellanicus were used, which were collected, fixed, and kept immersed in an aqueous solution of 10% formaldehyde. Results: the trachea of the penguin began caudally from the cricoid cartilage of the larynx, represented by 121.3±5.65 cartilaginous rings joined together, which extended to the syrinx (19.75±0.70 cm). Considering its five segments (I-V), the number of tracheal rings decreased in a cranio-caudal direction. The medial tracheal septum, which started caudally from the cricoid cartilage of the larynx, was approximately 2±0.08 cm and was formed by approximately 6.75±0.25 rings. The dimensions of the lumen of the trachea decreased cranio-caudally, with a statistical difference between segment I and the others (II to V). The syrinx of the tracheobronchial type presented 7.52±0.65 rings. Conclusions: these data will contribute to the understanding of the anatomy of this species, as well as to the diagnosis and treatment of possible tracheal pathologies found in it.
Η απώλεια της γης της επαγγελίας και οι επιπτώσεις στη θεολογία της κατά τα βιβλία του Δευτερονομίου και το προφήτη Ιεζεκιήλ.
Authors: Ελμέτσερκι Μάχερ
Published: July 2023

Η ιδιαίτερη σημασία της Γης της Επαγγελίας στη συνείδηση και στη ζωή του αρχαίου Ισραήλ είναι γνωστή στην Π. Διαθήκη, διαπερνά όλα τα βιβλία του κανόνα της, διατρέχει ολόκληρη την εβραϊκή παράδοση μέχρι σήμερα και αναγνωρίζεται από τη σύγχρονη έρευνα. Τα βιβλία του Δευτερονομίου και του προφήτη Ιεζεκιήλ κάνουν ιδιαίτερη αναφορά σε αυτήν καθώς στο πρώτο οι Ισραηλίτες είναι έτοιμοι να εισέλθουν στη Γη, ενώ στο δεύτερο έχουν ήδη εξορισθεί από αυτήν καθώς η οδυνηρή περίοδος της Βαβυλώνιας αιχμαλωσίας έχει ήδη αρχίσει. Και στις δύο ιστορικές στιγμές ο λαός βρίσκεται εκτός της Γης, την κατοπτεύει από μακριά και οι συγγραφείς των δύο αυτών βιβλίων θεολογούν για την αξία της και για την σχέση της με τον Θεό Γιαχβέ και με τον περιούσιο λαό του. Τα κοινά αυτά σημεία των δύο βιβλίων έχουν επισημανθεί από τους νεότερους ερμηνευτές, αλλά δεν έχει πραγματοποιηθεί μέχρι σήμερα μία συνολική διερεύνηση των θεολογικών ιδεών που περιλαμβάνονται στα βιβλία αυτά και αφορούν στη Γη, ώστε να διαπιστωθεί η μεταξύ τους σχέση. Η προσπάθεια αυτή γίνεται στη παρούσα μελέτη με την ερμηνευτική και θεολογική ανάλυση όλων των σχετικών αναφορών των δύο βιβλίων στην απώλεια και την αποκατάσταση της Γης σε σχέση με τον Θεό και τον Ισραήλ. τα βιβλία του Δευτερονομίου και του προφήτη Ιεζεκιήλ συγκρίνονται με επίκεντρο τη θεολογία της Γης της επαγγελίας. Επιβεβαιώνεται με μία ακόμη μαρτυρία η υιοθέτηση της θεολογίας του Δευτερονομίου από τον προφήτη Ιεζεκιήλ, τη φορά αυτή σε σχέση με την Γη της επαγγελίας, και κατά συνέπεια η προγενέστερη, προαιχμαλωσιακή, διαμόρφωση του βιβλίου του Δευτερονομίου, τουλάχιστον κατά το μεγαλύτερο μέρος του.
The problematic space between art, ambition, and gameplay: The Medium and the issues concerning difficult subject matter and gameplay in games
Authors: Marak Katarzyna , Markocki Miłosz , Chmielewski Krzysztof , Brzostek Dariusz
Published: July 2023

This article identifies and examines a couple of selected issues regarding speculative digital games which endeavor to deal with serious subject matter. Due to the fact that speculative games are exceptionally well suited for symbolic representation of sensitive topics, they allow their creators to conceive ambitious projects that aspire to be great works of audiovisual art. However, because game texts belong to a very specific medium, it is not always possible to realize this ambition in the context of gameplay. For reasons of space and focus this article uses one particular game, The Medium (2021), to serve as the primary example of how the problems which occur in the process of combining specific, engaging gameplay with serious, sensitive subject matter, lead to situations in which a game can fail to fulfill the player’s expectations. By analyzing the structure, gameplay, and storytelling tools employed in The Medium, the article places emphasis on the significance of the possible tensions between the intention of the designers of the game experience and the experiences, ideas, and interpretations the players themselves bring to the game text.
Detection of flood-hazard-prone zones using GIS modeling and AHP method in urban areas: the case of Amman Governorate
Authors: Al-Sababhah Noah
Published: July 2023

The aim of this study is to attempt a creative mapping of areas at risk of floods in Amman, using the Analytic Hierarchy Process (AHP) Method and GIS Modeling. The method (AHP) involves a weighting of a number of factors adopted by comparison. The main factors considered in this study were Elevation, Slope, Rainfall Intensity, Runoff, Land Use/Land Cover, Flow Accumulation, and SPI; these were reclassified and weighted to map the levels of flood hazards in the study area. Each factor/criteria was weighted and assigned a rank or score by using the Pairwise Comparison method to enable researchers to make a decision about the severity of the flood. The results show that about 28.2 % of the study area has a high to very high risk of flooding and that flooding can be very strong in the northwestern regions with high population density, while the risk becomes low in the eastern, southeastern, and western arid and semi-arid regions with low population density.
Las prestaciones por nacimiento y cuidado del menor: coordinación de sistemas de Seguridad Social dentro y fuera del entorno europeo.
Authors: Díaz Mordillo María Alexandra
Published: July 2023

El Real Decreto-Ley 6/2019, de 1 de marzo de medidas urgentes para la garantía de la igualdad de trato y de oportunidades entre mujeres y hombres en el empleo y la ocupación, agrupa las prestaciones de maternidad y paternidad en un único subsidio que ha dejado de ser un derecho transferible entre los progenitores. Teniendo en cuenta esta nueva configuración otorgada a las prestaciones por nacimiento, es conveniente analizar si se encuentran incluidas en el ámbito de aplicación material del Reglamento 883/2004 y en el de aquellos otros Convenios Bilaterales suscritos por España que también recogían la anterior prestación de maternidad (Andorra, Argentina, Australia, Chile, Ecuador, Filipinas, Marruecos, Paraguay, Perú, República Dominicana, Rusia, Túnez, Ucrania, Uruguay y Venezuela). Es decir, la nueva prestación por nacimiento y cuidado del menor, con una regulación diferente a las anteriores, tiene que encontrar su encaje dentro los instrumentos internacionales ratificados por España.
Empleadas de hogar: especial referencia a un colectivo olvidado.
Authors: Pico González Bianca Evelyn
Published: July 2023

El trabajo doméstico existe desde la antigüedad, siendo realizado en su mayoría por mujeres en sus propios hogares. Sin embargo, con el paso de los años se ha reconocido como una profesión, en donde se recibe una remuneración por la realización de estas labores, si se llevan a cabo en hogares ajenos al propio. A pesar de contar con la ventaja de ser reconocido como una profesión, nos encontramos con numerosas carencias y falta de protección en este ámbito, que afectan principalmente a mujeres, que son las que conforman en su mayoría este colectivo. En esta investigación abordaremos brevemente la historia del trabajo doméstico en España, para ver cómo era en los inicios, donde la sociedad estaba marcada por el pensamiento patriarcal, y como ha evolucionado hasta la actualidad. Abordaremos las principales características que tiene esta relación laboral, así como las carencias a las que se tienen que enfrentar. Finalmente, mencionaremos también el tema de la prevención de riesgos laborales en el sector del servicio doméstico.
Jan Kośmider z Ostrzeszowa. Zapomniany medyk z początku XVI wieku
Authors: Sroka Stanisław A.
Published: July 2023

W artykule ukazano sylwetkę Jana Kośmidera, zapomnianego lekarza z początku XVI w. Jan po studiach odbytych w Krakowie wykładał przez kilka lat (1499- 1503) na Wydziale Sztuk Wyzwolonych Uniwersytetu Krakowskiego. W 1511 r. uzyskał w Bolonii stopień doktora medycyny. Po powrocie do Polski inkorporował się do Wydziału Lekarskiego Uniwersytetu Krakowskiego. W 1513 r. był dziekanem tegoż fakultetu. Dał się poznać jako wytrwały obrońca prawa do wykonywania zawodu medyka tylko przez osoby legitymujące się doktoratem z tej dziedziny, za co czasami spotykały go szykany. Kariera Jana Kośmidera w Uniwersytecie Krakowskim była krótka ze względu na rychłą śmierć medyka w 1516 r. w trakcie panującej wówczas w Krakowie zarazy.
Should an Ad Agency Offer Geoconquesting or Protection from It?
Authors: Aseri Manmohan , Mehra Amit , Mookerjee Vijay , Xu Hong
Published: July 2023

This study examines the interaction between top-of-funnel advertising (e.g., search or display advertising) and bottom-of-funnel advertising (e.g., using a mobile application on a smart phone). We are particularly interested in the phenomenon of geoconquesting: the bottom-of-funnel advertising efforts of a firm to poach (or lure away) customers that have come to a competing firm’s physical store as a result of top-of-funnel advertising efforts by the firm. Geoconquesting efforts by a competing firm should reduce a focal firm’s incentive to invest in top-of-funnel efforts. Thus, a key challenge for an agent like Google that provides both top-of-funnel and bottom-of-funnel advertising services, is to balance the inherent conflict between the two in order to maximize the total revenue collected from the two forms of advertising. We develop a game-theoretic model to study the this phenomenon. A key result is that sometimes the agent benefits from not offering geoconquesting, but instead promises, after collecting a fee, to protect the advertisers from poaching on each other’s search traffic. Interestingly, such a protection service becomes more lucrative for the agent when a cheaper outside option for geoconquesting is available to the advertisers.
Anti-N-methyl-D-aspartate receptor encephalitis, a diagnosis not to miss
Authors: Valente Tiago , Brites Gonçalves Gisela , Duarte Valter , Jesus Gorete
Published: July 2023

Anti-N-methyl-D-aspartate receptor (Anti-NMDAR) encephalitis is a rare autoimmune disease, characterized by the presence of neuropsychiatric symptoms. It is sometimes mistaken for a psychiatric disorder and other times not considered in the differential diagnosis of an encephalitic process. Correct identification of this disease and prompt treatment are key for optimal recovery, which might take weeks to months. Many patients manifest severe symptoms, with depressed level of consciousness, breathing dysfunction and dysautonomia requiring admission to the Intensive Care Unit (ICU). We report the case a young male patient with anti-NMDA encephalitis who presented typical neuropsychiatric symptoms. Despite being diagnosed and treated in a timely manner, he did not respond well to first-line immunotherapy and was admitted to the ICU with neurological, respiratory, and cardiovascular dysfunction. This resulted in prolonged hospital admission and many infectious complications. Despite the severity of the disease, the patient managed to recover in the months following discharge from hospital.
Organization of еxchange activity in Trans-Dnieper Ukraine according to the publication "Banking Encyclopedia" in the late 19th – early 20th century
Authors:   State Institution Luhansk Taras Shevchenko National University, Altukhov Oleksii
Published: July 2023

The article considers and analyzes the informational significance of the leading economic specialized publication of the late XIX – early XX centuries. "Banking Encyclopedia". It is noted that in 1917 the second volume of this work, fundamental at that time in the field of economics, was published in Kyiv, which was entirely devoted to the study of stock exchange business in the leading countries, the Russian Empire and the Ukrainian lands. The co-authors of the work were leading contemporary economists and lawyers, in particular A. N. Antsiferov, G. V. Afanasyev, H. A. Baranovsky, M. N. Bogolepov, E. V. Vanshtein, I. M. Goldstein, N. S. Dobrokhotov, V. Ya. Zheleznov, A. M. Lazarev, D. N. Levin, E. S. Lurie, P. P. Migulin, N. D. Silin, P. B. Struve, M. P. Tugan-Baranovsky and others. Among the aspects considered were, in particular, the activities of the leading stock exchange institutions of Dnieper Ukraine: in Odessa, in Kyiv, in Kharkiv. Leading economist, professor of the Kyiv Commercial Institute, long-term deputy of the State Duma Leonid Mykolayovych Yasnopolsky became the editor-in-chief of the publication. Analyzing the scientific works collected in the Second Volume of the Banking Encyclopedia of 1917, the author of the article came to the conclusion that they make it possible to trace the state of affairs in the development of the stock market in the late nineteenth and early twentieth centuries. In particular, one can trace the state policy towards these financial institutions, which in many respects slowed down the development of the stock market, both in Ukraine and in the Russian Empire as a whole.
The phenomenon of "uprooting" – "rooting" of Ukrainian emigration on the territory of interwar Czechoslovachchyna (1918–1939): evaluation over time
Authors:   Vasyl’ Stus Donetsk National University, Zubko Olha
Published: July 2023

To this day, the semantic content of the term "emigration" and its derivatives remains undefined and is perceived in society in different ways: from principledness to treason, social outsiderness, earning money to the search for adventure, adventurism. Therefore, the problem of emigration still requires a more detailed and in-depth study. In particular, the so far unexplored emigration everyday life needs attention. The proposed article deals with the phenomenon of "uprooting (UPR) – rooting (CSR)" of Ukrainian political emigrants on the territory of interwar Czechoslovakia. Modern researchers read everyday history in two planes, which can be conventionally called "technology of life" or "level of life" (tools and ways of ensuring the sphere of everyday needs: what to eat and wear, where to live, what to move around, what to use in work, study, leisure, how to take care of health) and "axiology of life" or "life style" (meaningful content, system of life guidelines (how and for what to live: values, morals, habits, priorities, tastes)). In the epicenter of our attention is the value plane. The concept of "uprooting" includes "being-from-the-edges", hence hopelessness, political-social, cultural-economic alienation. Whereas the concept of "rooting") – "being-for-oneself") – cultural, political fullness of life, self-actualization and self-realization of all emigration essential forces, opportunities, abilities, meanings of culture, goals and values, manifestations of spirituality, creativity, freedom, sovereignty and responsibility.
The respiratory system and associated disorders
Authors: Wheeldon Anthony
Published: July 2023

Respiratory disease is ubiquitous in hospitals and community healthcare settings in the UK. Nurses, therefore, must be able to understand the physiology and pathophysiology that underpins the care they provide for people living with a respiratory disorder. This article summarises the fundamental anatomy and physiology of the respiratory system and respiration. It also explores the pathophysiological changes that occur in the four most common respiratory conditions, namely pneumonia, lung cancer, asthma and chronic obstructive pulmonary disease. Key elements of a comprehensive respiratory assessment and how nurses can determine acute deterioration are explored. The case study and reflective questions aim to enhance the reader's understanding of respiratory assessment and nursing care.
Updating the standards should not mean moving the goalposts
Authors: Foster Sam
Published: July 2023

Executive Director of Professional Practice, Nursing and Midwifery Council, considers the question of changes to the standards for nursing education, and what underpins these
£20m to Look into How Life Works
Authors: Knight Helen
Published: July 2023

Magnetic resonance equipment will probe molecular structures
Diesel Cars may have a Future
Authors: Ford Jason
Published: July 2023

Bosch experiments with a system that dramatically reduces NOx
Disrupters Prepare Banking for 4th Industrial Revolution
Authors: Stirling Will
Published: July 2023

From APIs to blockchain, a host of financial technology (or fintech) platforms are helping manufacturers secure the funding they need to drive growth.
A Review of the Current Unmanned Aerial Vehicle Sprayer Applications in Precision Agriculture
Authors: Delavarpour Nadia , Koparan Cengiz , Zhang Yu , Steele Dean D. , Betitame Kelvin , Bajwa Sreekala G. , Sun Xin
Published: July 2023

Highlights

A comprehensive review of the current Unmanned Aerial Vehicle Sprayer in precision agriculture applications.

Comparison of manned and unmanned aerial sprayers in precision agriculture.

Latest developments of commercialized UAV sprayers available on the market.

Abstract. Unmanned Aerial Vehicles (UAVs) are becoming more broadly used for improving agricultural spraying applications. However, compared with the nearly 100 years of data accumulated on manned aerial applications, UAV sprayers are relatively new, and associated technologies are in the early stages of development. The objective of this paper is to give a comprehensive review of the current UAV spraying platforms with a comparison to manned aerial sprayers and a discussion of their application, performance, and efficiency. A total of 213 peer-reviewed and non-peer-reviewed articles, extension papers, government websites, and company websites were reviewed and cited in this study. We also discuss factors that could influence the effectiveness of aerial spraying applications, such as release height, wind speed, vortex strength, and droplet size. Finally, we review the latest UAV sprayers available worldwide and present technology gaps in those platforms. We highlight areas that require improvement, particularly in autonomous navigational controllers and spraying systems. Keywords: Droplet distribution, Plant protection, Precision agriculture, Spot spraying, UAV sprayer.
Bewegte deutsche Familiennamen in Ungarn
Authors: Szilágyi-Kósa Anikó
Published: July 2023

German proper names have a long history in Hungary: since the founding of the Hungarian state in the 10th century, the country has maintained lively linguistic and cultural contacts with the German-speaking area, resulting in a large, historically grown German-language proper name material in Hungary, in which above all anthroponyms and toponyms are represented. This article is devoted to German personal names in Hungary. This name material, which arose in language contact, is characterised by numerous spontaneous contact phenomena. They have been standardised since the end of the 19th century by the registers of civil status offices, but before that numerous spelling (and pronunciation) variants developed in the language triangle of the written German language, the spoken dialect and the official Hungarian language. These parallel forms of names testify to a phonematic-graphemic wealth of forms: e. g. the surnames Stahl/Stáhl/Stál, Westerkam/Westergam/Westergom. They are researched in the databases of the Central Office of Electronic and Administrative Services of Hungary (KEKKH).

On the other hand, German surnames have also been deliberately “hungarised”; this article will demonstrate, on the basis of selected cases of name changes, which linguistic strategies were pursued in the individual cases by the bearers of the names (who also gave the names).
Verhochdeutschung von Toponymen der Deutschschweiz seit dem 19. Jahrhundert
Authors: Thöny Luzius , Schneider Thomas Franz
Published: July 2023

The diglossia in German-speaking Switzerland affects many aspects of language use of the speakers of this area, among them the question of how to render toponyms in writing. In the 19th century, toponyms were generally transposed from spoken Swiss German to Standard German. In this article, we discuss the main strategies of this transposition in the two main sources of toponomastic data for the canton of Bern in the 19th century, i. e. the gazetteer by Durheim and the so-called Siegfriedkarte (the predecessor of the modern official map, the Landeskarte). We also discuss some errors made by their authors when transposing the names, e. g. by mistakenly reverting certain dialectal changes (hypercorrection) or by semantic reanalysis. In the middle of the 20th century, a new regulation issued by the Swiss authorities mandated that toponyms should generally be spelled in accordance to how they are spoken by the local population. This new regulation was implemented for local names, i. e. names of fields, forests, rivers, small settlements etc., but not for names of larger settlements, well-known mountains, rivers or regions, resulting in some inconsistencies which persist on the official maps until today. An initiative implemented by some cantons in the early 21st century to render spoken dialect features more accurately in the spelling of toponyms had to be abandoned because of the resistance of the local population. Until today, and likely also in the future, the spellings of toponyms of German-speaking Switzerland vacillate between adherence to the orthography and sound patterns of (Swiss) Standard German, on the one hand side, and an accurate representation of spoken Swiss German dialect forms, on the other.