bluuebunny/crossref_metadata_2025 huggingface dataset:
IN SILICO IDENTIFICATION TESTING OF TRITERPENE SAPONINES ON CENTELLA ASIATICA ON INHIBITOR RENIN ACTIVITY ANTIHYPERTENSIVE
Authors: ASTIANI RANGKI , SADIKIN MOHAMAD , EFF APRILITA RINA YANTI , FIRDAYANI  , SUYATNA FRANCISCUS D.
Published: April 2022

The renin-angiotensin-aldosterone system (RAAS) has an essential role in the occurrence of hypertension. Two drugs that act on SRAA are ACE Inhibitor and ARB. ACE inhibitor and ARB are two antihypertensive drugs that act on RAAS. However, both drugs are not fully effective because they produce incomplete suppression of RAAS. The therapeutic potential of the two drugs is limited, so it is necessary to find out other drugs that are more effective in inhibiting the RAAS system. Renin-inhibitors are evolving as options that can inhibit at the highest levels in RAAS. Discontinuation of renin inhibitor therapy does not cause rebound hypertension as in ACEIs and ARBs. The search for natural renin inhibitors began to be carried out as an alternative to aliskiren. Renin-inhibitors derived from natural ingredients generally come from the class of saponin compounds or polyphenol compounds. One of Indonesia's native plants that contain saponins and polyphenols is Centella asiatica. Thus, research on the antihypertensive potential of these plants was carried out. It is expected that the Centella asiatica plant has a renin inhibitor effect as a blood pressure-lowering drug derived from herbs but has the same effect as aliskiren. The research method was carried out in silico to test the activity of compounds that have potential as antihypertensives in the Centella asiatica plant. The method used is molecular docking, with the docking software used being Molegro Virtual Docker (MVD) 6.0. The results showed that madecasoside and asiaticoside from the Centella asiatica plant have intense renin inhibitor activity, with a mean re-rank score of-105.27 and-93.67, respectively. The conclusion is that madecasoside has similarities with aliskiren with a re-rank value of-105.27. The smallest re-rank value indicates the similarity and strong protein binding between the tested ligand compound and the comparison protein.
COMPARATIVE MODELING FOR SACCHAROMYCES CEREVISIAE RAD56 USING SWISS-MODEL, I-TASSER, AND PHYRE2
Authors: PARITALA VENU
Published: April 2022

Objective: RAD56 is a protein its causes pathological conditions of Kohler disease, Mueller-Weiss syndrome, which leads to hindfoot pain. RAD56 is considered an impressive drug target for various illnesses. The experimental 3D structure of RAD56 is not available. Therefore, the present study aims in developing a homology model using 3 different software and evaluate the best model.
Methods: The developing homology modeling on RAD56 is built utilizing three diverse software’s to be specific Swiss-Model, I-Tasser, and Phyre2. All the predicted models were analyzed and approved by PROCHECK, PROSA, Errat, and Verify_3D.
Results: Homology Modeling anticipated from Swiss-Model appeared best comes about with 88.6% of the buildups within the most favorable locale, 11.2% within the permitted region, 0.6% within the liberally permitted locale, and 0.2% within the refused locale. PROCHECK, PROSA, Errat, and Verify_3D, too, affirmed the same.
Conclusion: Homology Modeling was created for RAD56 utilizing Swiss-Model, I-Tasser, and Phyre2. The models created were validated utilizing PROCHECK, PROSA, Errat, and Verify_3D. This investigation approved the homology model created by is best Swiss-Model 88.6, vigorous as well as solid sufficient to be utilized for future pondering.
LIPID-POLYMER HYBRID NANOCARRIERS AS A NOVEL DRUG DELIVERY PLATFORM
Authors: JAISWAL PANKAJ KUMAR , KESERWANI SHIKHA , CHAKRABARTY TAPASH
Published: April 2022

The main aim of my review to discuss the most prominent nanocarrier, “Lipid-Polymer Hybrid Nanoparticle” (LPHNPs) that overcomes the limitation of lipid and polymeric nanoparticles. That consists of polymeric core and lipid outer layer. The polymeric core encapsulates both hydrophilic and hydrophobic drugs and lipid shell provides a coat that gives a barrier to prevent drug leakage and easily penetrate into the skin. The LPHNPs has significant application in drug delivery, drug targeting, cancer treatment, brain drug delivery, multiple drug delivery, delivery of diagnostic imaging agent and Small interfering Ribonucleic acid (siRNA).
This session is based on literature information in which LPHNPs were prepared by Two-step and Single-step method. Most of the researcher use the Single-step method by emulsification solvent evaporation and Nanoprecipitation method that are easy to prepare LPHNPs. The Polylactic Glycolic acid (PLGA), Poly € caprolactone, Chitosan, Alginate, Dextron, Sodium Alginate, etc used as polymeric core and Stearic Acid, Palmitic Acid, Cetyl Alcohol, Behenol Alcohol, etc used as lipid core. All results were analyzed by us according to the literature and authors’ expertise. The drug release depends on diffusion processes, followed by erosion, then swelling of the matrix. The lipid shell provides a biocompatible shield that acts as the phospholipid bilayer of skin and easily penetrates into the skin. That also capable to deliver the multidrug and diagnostic imaging agent for the treatment of cancer.
The Lipid-Polymer Hybrid Nanoparticles are the most prominent nanocarrier for drug delivery. That is capable to deliver both Hydrophilic and Lipophilic drugs and show high bioavailability.
BIPHASIC DISSOLUTION MODEL: NOVEL STRATEGY FOR DEVELOPING DISCRIMINATORY IN VIVO PREDICTIVE DISSOLUTION MODEL FOR BCS CLASS II DRUGS
Authors: SARKAR PRASENJIT , DAS SAUMYAJYOTI , MAJEE SUTAPA BISWAS
Published: April 2022

In vitro dissolution study should ideally be designed to predict in vivo performance precisely, providing key information on the bioavailability and establishing IVIVC. Development of discriminatory in vivo predictive dissolution model and the establishment of IVIVC is difficult to achieve with BCS Class 2 drugs as they exhibit variable absorption along the GI tract owing to pH-dependent solubility, especially for Classes IIa and IIb. In this context, the biphasic dissolution model is a powerful technique for investigating the interplay between dissolution, precipitation and partitioning of various poorly soluble molecules. The dissolution test medium comprising of immiscible aqueous and organic phases enables maintenance of sink conditions and easy quantification of poorly soluble drug partitioning into the organic phase. In the review, novel efforts have been taken to provide comprehensive information on challenges associated with the establishment of IVIVC for BCS Class II drugs, various approaches being adopted for developing discriminatory in vivo predictive dissolution model, significant outcomes of studies on biphasic dissolution model to predict the in vivo dissolution behaviour of BCS Class II drugs and the problems with the use of biphasic dissolution model including the status of FDA on the same.
INVESTIGATION OF ANTIBACTERIAL ACTIVITY OF METHANOLIC EXTRACT AND ISOLATION OF STEROL AND TRITERPENOIDS FROM GREWIA TILIAEFOLIA VAHL LEAF
Authors: DHARMASOTH RAMA DEVI , GANGA RAO BATTU , NAGESWARA SWATHI , BASAVAIAH KELOTH
Published: April 2022

Objective: In the present study, we have discussed the antibacterial activity of methanolic extract of Grewia tiliaefolia Vahl leaf and the isolation of pure phytochemicals by using column chromatography.
Methods: The powdered material was extracted with methanol using a soxhlet extractor and isolation of compounds by column chromatography. Evaluation of antibacterial activity determined the zone of inhibition by disc diffusion method.
Results: Three compounds were isolated from methanolic extract of the leaf of Grewia tiliaefolia using column chromatography, namely daucosterol, lupeol, and friedelin were purified after isolation and characterized by using UV, FTIR, NMR, MASS spectroscopic techniques, and antimicrobial activity was carried out on the crude methanolic extract a higher zone of inhibition was observed against Staphylococcus aureus with a zone diameter of 34.1±0.513 mm at a concentration of 10 mg/ml.
Conclusion: The results observed in this research work conclude that the methanolic extract showed good antibacterial activity may be due to the compounds isolated like daucosterol, lupeol, and friedelin.
Article Modelase by Fajate – Direct Sale and manufacture products directly from industry to consumer
Authors: Catarino Mariana Garcez
Published: April 2022

This article works the direct sales market focusing on the Modelase by Fajate project, a form of marketing promoted by companies such as Jequiti, Natura and Avon, which sell and manufacture products directly from industry to consumer. In the current phase of the economy and with the productive reformulation of capital and labor relations, in which the expanded reproduction of capital is sought, the configuration of the globalized economy has led to a new order between the upper and lower circuit. The recent dynamics of the Brazilian economy have influenced the expansion of the two circuits of the urban economy in large Brazilian cities. This business strategy allows the insertion of a wide range of workers, usually urban, integrating into the dominant production model, from a commercial contract. In the understanding of this process, the analysis was imposed in which the accumulation of capital is enhanced in the form of exploitation of the labor force. This articulation, which explains the combined and concomitant existence of different technological stages within the same set of productive processes, makes it indisputable that the criterion of "modern" and "backward" are faces in the same way of capitalist social reproduction. If in the past the direct selling business model was adopted by a few companies, today it is adopted by large and small. In this sense, being extremely important the understanding of the transformations of large companies, which are part of the superior circuit of the economy, with the lower circuit, in their search for expanded reproduction of capital through primitive accumulation, present in many forms of contemporary work. The companies with the direct sales business model that distribute their products through catalogs (Avon and Natura) were presented, demonstrating the peculiarity of each activity in its differentiations within the direct sales system. Adopting the Fajate project to this world of renewing and expanding, in the period of globalization.
A Survey of Dearth and Trend of Female Literary Writing in English from the Northeast Nigeria
Authors: Dahiru Muhammad
Published: April 2022

There is an apparent paucity of literary works written by women in English from the northern vis-à-vis southern part of Nigeria in the corpus of the country’s literature. Adopting a mixed-method approach, this paper surveys availability or dearth of female writers in the northern region by focusing on the three north-eastern states of Borno, Yobe, and Gombe states. Quantitative and qualitative approaches, through questionnaires and interviews, and Consensus Workshop, through Focus Group Discussions (FGD), are administered to gather the data for the discussion. The paper found a dearth of women writers in the northeast region and concludes that readership, publication opportunities, level of education, and social choices of the medium of expression are among the factors responsible for the dearth. The paper also found a recurrent motif of love, family, and marriage as the thematic and stylistic complexities of the available female work of fiction that follow theSoyayya trend. Possible amenable measures, which include organizing competitions and book projects, are proffered as recommendations.
Rethinking Interior Spaces for Work from Amidst the Pandemic
Authors: Dubey Anshuman , Jain Vanshika , Chhabra Mehak
Published: April 2022

Abstract: Amidst the Covid-19 pandemic, people refrained from going out and started working from home. Millions of employees' working arrangements have changed, and many may continue to work from home in some form for the foreseeable future. This research paper addresses the everyday challenges people face while working from home. To address the lack of workspace, people formed a separate working area or an integrated space with the habitable rooms. Spending the maximum amount of time indoors impacted them psychologically. Hence, there is a need to re-design the current workspace for a better lifestyle. The study attempts to establish a relationship between habitable spaces and work areas in residence. Keywords: Work from Home, Pandemic, Workplace Design, Interior Design, Environmental Stimuli, Mental Wellbeing
Detecting Attention Deficit Hyperactivity Disorder (ADHD) Inflicted Humans using Long Short-Term Memory (LSTM)
Authors: Jeswani Prof. Jaya , Soni Priya , Khatri Iqra , Satoskar Jatin
Published: April 2022

Abstract: Attention Deficit Hyperactivity Disorder (ADHD) is a common psychiatric disorder characterised by persistent patterns of inattention, hyperactivity, and impulsivity in children. The risk factor is that these children are frequently entangled in learning difficulties, which lead to frustration when they reach adulthood. This study uses functional Magnetic Resonance Imaging data for the resting-state brain to present an effective approach for ADHD identification at an early stage. The proposed method is based on seed correlation, which calculates the functional connectivity between seeds and all other voxels in the brain.This paper gives a walk through of the steps for using machine learning to analyse rs-fMRI data and, more specifically, to distinguish Attention Deficit Hyperactivity Disorder (ADHD) from healthy controls. I discuss (1) feature extraction with masks, (2) the advantages and disadvantages of long short term memory networks (LSTM) for classifying fMRI data, and (3) hypothesis testing and its application in model evaluation. Keywords: ADHD, f-MRI, Impulsive behaviour, Anxiety, LSTM
Song Recommendation Using Facenet Emotion Technology
Authors: Chaukade Abhinay , S Hannah
Published: April 2022

Abstract: In today’s technological revolving era, everyday new types of technologies are being discovered. Various types of technologies, devices, softwares etc. are being introduced daily. According to the experts the facial expression is derived from the internal biological motions of the muscles that lie under the skin. It also deprives the emotional state of the person. But, in this world where communication has become an important thing, the facial expression is the mean of the non-verbal communication, by which we can understand the current behaviour of the person without even uttering single word. For recognition of an individual’s mood, the system uses Facial Expression Recognition (FER) concept and depending on the recognized mood, song is played. This program removes the time-consuming and the hard work of manually searching and playing the songs from internet or any other sources. So, we introduced an application that suggests the songs based on the facial expression or emotions. This application will use the camera feature of any device to read the facial expression of the user and then define a song accordingly. Furthermore, this application will have an additional feature of offline functionality. These are the modules that our application will function on. Our application will imply on various algorithms and packages and application interfaces. We can precisely say our application will use Python package of Tensor Flow (TF) for the facial expression. In this way, the proposed system will contribute towards the healthy emotion building of the humans and will technologically evolve the existing music recommendation system in a new wholesome way. Index terms: Facial Expression Recognition, Python Package, Tensor Flow, API, BBOX
A Survey Towards Labor-saving the Corporate Recruitment
Authors: Kurian Smitha , Khan Mohammed Aman , P Hema Priya , Singh Manavpreet , Norbu Lobsang
Published: April 2022

Abstract: Traditional recruiting approaches are becoming insufficient due to the fast expansion of employment markets. This is due to the fact that the corporate business is expanding at a rapid pace, and each organisation receives a large number of applications. On the practical side, reading and analysing each and every resume manually is an impossible and time-consuming task. To address this issue, this research offers a detailed and repeatable evaluation of the performance of Automatic Interviewing software, providing the framework for future benchmarking and relevant comparison studies. We also discovered that SpaCy consistently outperforms for Information Extraction and Named Entity Recognition. Keywords: Automated recruitment; deep learning; convolutional neural networks (CNN), LSTM, RNN;
Evolution of Society through Artificial Intelligence: A Review
Authors: Adnan Mohammed
Published: April 2022

Abstract: AI has been around for years. It is now gaining popularity in the tech world for two main reasons: big data sets and integration capabilities. In 2010 the Techonomic conference Eric Schmitt suggested that every two days now we are building as much information as we did from the beginning of civilization until 2003. Today, AI is currently being used in education, health care. Soon, smart machines will replace or improve people's skills in many areas, previously thought strongly within the human domain. for more than a decade, or sometimes even a hundred, for example, new buildings are usually designed to last 100 years. This study aims to examine the literature on the impact of artificial intelligence on society and its transformation. Keywords: Artificial Intelligence (AI), Impacts of AI, Problem solving through AI, ML and AI, AI-driven Tools
Review on Methodologies Used for Knocking Detection and Intensity Evaluation in Internal Combustion Engines
Authors: Deva Dinesh
Published: April 2022

Abstract: Extracting the knocks characteristics is the key of ignition control in auto-ignition compression engines, especially those severely suffered from abnormal consumption in the engine chamber. Most of the advanced detecting methods of knocking are generally related to the two main variables, including engine cylinder pressure signals and the engine cylinder block vibration signals, commonly measured using piezoelectric accelerometer sensors. Being familiar with different approaches capable of determining the engine knocking occurrence probability as well as providing suitable methods for knock intensity evaluation is significantly helpful to propose a comprehensive predicting model for measuring the level of oscillation pressure waves frequencies originated by the knocks. Following by predicting the knock intensity and extracting the knock feature, optimizing the engine operation in terms of fuel consumption, thermal efficiencies, and lifetime duration would be possible. For this aim, the current paper is addressed with overviewing upon the researches performed in the regard of developing high accurate models and optimized knock detection approaches. Keywords: auto-ignition, Internal combustion engine, Knocking detection approach, Knock intensity evaluation.
Speech Based Emotion Detection Using Deep Learning
Authors: Dsouza Prof. Martina , Adhav Rohan , Dubey Shivam , Dwivedi Sachin
Published: April 2022

Abstract: The Mechanized Discourse Feeling Acknowledgment may be an intense handle because of the hole among acoustic characteristics and human feelings, which depends emphatically on the discriminative acoustic characteristics extricated for a given acknowledgment assignment. Distinctive people have different emotions and through and through a distinctive way to precise it. Discourse feeling do have distinctive energies, pitch variations are emphasized in case considering distinctive subjects. Subsequently, the discourse feeling location may be a requesting assignment in computing vision. Here, the discourse feeling acknowledgment is based on the Convolutional Neural Network (CNN) calculation which employments distinctive modules for the feeling acknowledgment and the classifiers are utilized to distinguish feelings such as joy, astonish, outrage, impartial state, pity, etc. The dataset for the discourse feeling acknowledgment framework is the discourse tests and the characteristics are extricated from these discourse tests utilizing LIBROSA bundle. The classification execution is based on extricated characteristics. At long last able to decide the feeling of discourse flag. Keywords: Deep Learning, Speech emotion, Tensor Flow, CNN
Blind Assistance System using Image Processing
Authors: Devi P. Rama , Sahaja K. , Santrupth S. , Harsha M. P. Tony , Reddy K. Balasubramanyam
Published: April 2022

Abstract: Eye diseases usually cause blindness and visual impairment. According to the World Health Organization, around 40 million people are blind, while another 250 million have some form of visual impairment. They come across many troubles in their daily life, especially while navigating from one place to another on their own. They often depend on others for help to satisfy their day-to-day needs. So, it is quite a challenging task to implement a technological solution to assist them. Several technologies have been developed for the assistance of visually impaired people. One such attempt is that we would wish to make an Integrated Machine Learning System that allows the blind victims to identify and classify real-time objects generating voice feedback and distance. Which also produces warnings whether they are very close or far away from the thing. Keywords: Blindness, Visual impairment, Machine Learning, Real-time objects
Electrical Vehicle to Vehicle Charging Without Charging Station
Authors: Chaudhary Dr. Sunil Kumar , Pachauri Prem Shankar , seth Ani , Yadav Dheeraj Kumar , Singh Shubham , Singh Atul
Published: April 2022

Abstract: Electrical vehicles will be the next biggest revolution in vehicle industries. The present infrastructure, which is currently in use has lot of drawbacks and shortcomings which needed to be overcome. The biggest problem is lack of charging infrastructure for electrical vehicle and so electrical vehicle users always have this charging anxiety in their mind while picking up electrical vehicle for some purpose, so this paper will provide an incredible solution to this problem by implementing a V2V charging infrastructure without bringing a charging station in to the picture. This V2V charging infrastructure will use conducting charging as medium of charging. Keywords: vehicle to live, vehicle to home, vehicle to grid, bidirectional charging
Cloud Based COVID-19 Testing Management System
Authors: Wangyal Rinzen , R Dr. Murugan
Published: April 2022

Abstract: Nowadays, COVID19 Testing Management System is one of the most essential tools that are mostly used in Testing Lab; it is mostly used to manage COVID19 medical lab related activities. In this project we tried to develop a computerized and web-based Cloud COVID19 Testing management system. Our main intention is to allow this application to be used in most retailing COVID19 lab, where a small point of customization will be required to each COVID19 lab in the implementation period. This system is designed to overcome all challenges related to the management of diagnostic that were used to be handled locally and manually. The system is an online COVID19 lab manager application that brings up various COVID19 test working online. Using this system, it will help us to records all transaction made at the daily tests; recognize all customers, employees, etc. It will manage all activities around the COVID19 lab that increases productivity and maximize profit, it will also be minimizing the risk of getting loss because all transactions are recorded to the system.
Comparison Between Agriculture Soil and Common Land Soil in Relation to Soil Edaphic Factors and Nematode Community
Authors: Trambadiya Krishna , Kanabar Riddhi , Visavadia Manish
Published: April 2022

Abstract: Plant-parasitic nematodes may cause mechanical damage to the roots, stems, leaves, and flower structures of many plants. The host plant is more important in the nematode population. The control of these nematodes is more difficult than that of other pests because they mostly inhabit the inner part of the crops. Some Edaphic factors and secondary metabolites of plants play an important role in nematode control. The present study aims to analyze the comparision between agriculture soil and common land soil in relation to soil edaphic factors and nematode community. For testing nematode infection in crops, different agricultural fields were selected from different areas in and around Junagadh District. We have selected some agriculture sites in which nematode population were widely found. On the other hand, common land soil were no nematode population found. Edaphic factors like soil pH, Temperature, Moisture, Organic Carbon, Electrical Conductivity, Phosphorus, and Potassium were effective in the nematode growth. Results indicate that Soil temperature and Moisture were more affected in the nematode community. Further studies for the control of these nematodes are underway. Keywords: Nematode, Edaphic factors, Temperature, Moisture, Organic Carbon
Development of Geopolymer Mortar Using Fly Ash
Authors: Kandoria Vikrant Singh , Kaur Loveleen , Sharma Dr. Sanjay
Published: April 2022

Abstract: The purpose of this study was to investigate the potential applications of geopolymer mortar in the building industry. With rising pollution and climate change, it is vital to select a greener and more environmentally friendly material for your project. Because cement contributes significantly to environmental damage, we must limit our reliance on it. Geopolymer mortar, which is made from alumina and silica-rich by-products such as fly ash and rice husk ash and is utilised in the construction of roads and buildings, is another sustainable material. An alkaline solution is used for the activation of these compounds. The compressive strength of geopolymer mortar was investigated in this study utilising a variety of modified alkaline solution ratios. As a result, the creation of a geopolymer mortar may help to reduce dependency on cement. Keywords: Ordinary Portland cement (OPC); Fly Ash (FA); compressive strength test
Design and Analysis of Surveillance Robot
Authors: Lakare Puja , Pharate Pranav , Khadkekar Pratik , Jadhav Pragati , Kaldate Prof. A. P.
Published: April 2022

Abstract: The main objective behind this paper is to develop a robot for surveillance in industrial & war areas. The project is designed to develop a robotic vehicle using android mobile. For remote operation attached with wireless camera for monitoring purpose. The robot along with camera wirelessly transmit real time video with low light vision capabilities. This is kind of robot will be helpful for spying purpose in war fields. The wi-fi technology is relatively new as compared to other technologies and there is huge potential of its growth and practical application. The security system then acts on these command and responds to the user. The ESP 32 camera is attached with security system for remote surveillance. This kind of robot will be controlled by a human operator, sometimes from a great distance
self-control therapy untuk mengurangi perilaku merokok pada remaja
Authors: Sutoko Ibnu , Suryaningrum Cahyaning
Published: April 2022

Adolescence is a time when individuals are easily inﬂuenced by the environment. One of the environmental exposures during adolescence is the use of cigarettes. Not many teenagers are able to cope with environmental inﬂuences, thus creating a sense of conformity to smoking. The cause of adolescents not being able to overcome conformity is a lack of self-control when in situations that trigger smoking. The purpose of this study is to reduce smoking behavior in adolescents by increasing self-control when in situations that trigger smoking. Subjects consisted of four teenagers aged 16 -18 years old. The assessment method used are interview, observation, Glover-Nilsson Smoking Behavior Questionnaire (GN-SBQ) and self-report. The intervention technique used is group self-control therapy. The results of the intervention showed a gradual decrease in smoking behavior after each group member was able to apply self-control techniques when in situations that trigger smoking. The decrease in smoking behavior can occur because with self-control, each subject in the group can control the sense of conformity that triggers the subject to smoke.
Ayurveda view on Prameha w.s.r. to causes and approaches of Management
Authors: Daundkar (Avhad) Archana , Sawant Pravinkumar , Avhad Ganesh
Published: April 2022

Prameha is pathological condition which mainly arises due to the excessive consumption of Madhura, Snigdha, Guru and Picchila Aharas. As per modern view sedentary habits, stress and lack of exercises, etc. are responsible for such types of metabolic disorder. Prameha is related to the diabetes as per the modern science, the disease mainly found in middle aged and elderly population but current life style also increases prevalence amongst young population. Aharaj & Viharaj factors play important role towards the disease pathogenesis including Kam-krodha, Shoka, Chinta and Bhaya, etc. are play vital role towards the disease pathogenesis. This article presented view on prameha W.S.R. to its causes and management.
Comparative overview of Registration and Approval process for Generic Drugs in BRICS Countries
Authors: R. Deore Dhanashree , H. Patel Pinkal
Published: April 2022

BRICS are economically incorporated the developing markets of Brazil, Russia, India, China, and South Africa. In, the Pharmaceutical market rapidly increasing growth in the administration framework of Medication and Administrative Medication Law. The main objective of this study is to compare the Registration and Approval process in different Countries for Generic Drugs. The Registration process in India and China are different. Even, though Brazil, Russia, and South Africa also follow CTD format in Module I for Requirement of registration. All countries include the highest world pharmaceutical economy in the world. To create a significant opportunity for pharmaceutical companies by direct foreign investment and showing growth. They have the largest entity on the global stage of the world. The main goal of this study is to the comparison of generic medication of drug registration process in BRICS countries, in, that Russia and Brazil have different approval processes so that the newer technologies we have found in the countries. India, South Africa, and China have CTD format requirements so, that this Module-1 is very different. More rising largest globally emerging BRICS markets are having significant or beneficially Opportunities. According to different guidelines, we are opinion to and that regulation are carry out. In, Brazil are having good, human service and current medication it is economically good for the developing market in global prospect. ICH prefers that the anniversary of preparing a dossier for Safety, Quality, and Security of API and Product Specification. So, that in this review we have discussed the above Registration and Approval Process BRICS countries.
Therapeutic Effects of Removable İntraoral Class III Appliances on Dentofacial Structures: A Comprehensive Literature Review
Authors: YAVAN Mehmet Ali , ÇETİN TAŞKIRAN Gülcan , GÖKÇE Gökçenur , HAMAMCI Nihal
Published: April 2022

The aim of this comprehensive review was to shed light on removable intraoral Class III appliances and their dentoskeletal effects in growing Class III subjects. Recently, intraoral Class III appliances have been recommended in cases of Class III malocclusions arising from maxillary retrusion instead of the Facemask appliance, which is commonly used in children at development age, due to its disadvantages including large volume and non-esthetic design, lack of cooperation, and its contribution to the irritation in the anchorage site. For these reasons, the appliances used in the treatment of Class II malocclusions have been modified for the treatment of Class III malocclusions. Among these, Fränkel Appliance III, which was introduced by Rolf Fränkel, is the most well-known modified appliance and the other well-known examples include Bionator III, Reverse Twin Block, and Magnetic Appliance III. Additionally, the other removable intraoral appliances introduced in the literature include Modified Tandem and Double-plate Appliance. The present review examined the designs of these appliances reported in the literature as well as their skeletal and dentoalveolar effects on the maxilla and mandible.
Covid-19 Enfeksiyonunda Akut İnme: Nöroloji Yoğun Bakım Deneyimi
Authors: GÖRGÜLÜ Ümit , ŞAHİN Mustafa Harun , BEKTAŞ Hesna
Published: April 2022

Amaç: Coronavirus hastalığı 2019 (Covid-19), inme gibi trombotik olaylardaki artışla ilişkilendirilmiştir. Bu çalışmanın amacı, Covid-19'un inme hastalarının klinik, laboratuvar ve prognoz sonuçları üzerine etkisini araştırmaktır.Materyal-Metot: 1 Eylül 2020-30 Ocak 2021 tarihleri arasında Nöroloji Yoğun Bakım Ünitesinde tedavi gören akut inme ve Covid-19 birlikteliği olan hastalar retrospektif olarak çalışmaya dahil edildi. Hastaların demografik özellikleri, tıbbi komorbiditeleri, nörolojik semptomları, inme risk faktörleri, inme şiddeti, laboratuvar test sonuçları, görüntülemeleri ve hastane sonuçları kaydedildi. Bulgular: Nöroloji yoğun bakımda tedavi edilen 287 Covid-19 hasta dosyası retrospektif olarak incelendi ve 20 hasta çalışmaya dahil edildi. Hastaların yaş ortalaması 72,9 ± 16 (31-95), cinsiyetleri 11 erkek (%55) ve 9 kadındı (%45). 9 hasta inme geçirmeden önce Covid-19 enfeksiyonu tanısı almıştı, 11 hastada (%55) ise başvuru sırasında RT-PCR test ile (Real-time reverse transcription polymerase chain reaction) Covid-19 enfeksiyonu teşhisi konuldu. 18 hastada iskemik inme, 2 hastada intraserebral kanama vardı. Başvuru sırasında 13 (%65) hastada National Institutes of Health Stroke Scale Scoress koruna göre orta şiddette inme tespit edildi. En sık başvuru şikayetleri, hemiparezi veya hemipleji (%85), konuşma bozukluğu (%60) ve bilinç bozukluğuydu (%60). Hipertansiyon (%75), diyabetes mellitus (%35), koroner arter hastalığı (%30) en sık eşlik eden komorbit hastalıklardı. Hastalarda prokalsitonin, C-reaktif protein, eritrosit sedimentasyon hızı, interlökin-6, D-dimer, fibrinojen, laktatdehidrogenaz, total bilirubin yüksekliği ve düşük lenfosit seviyeleri mevcuttu. Vaka ölüm oranı %30’du.Sonuç: Covid-19 komorbid hastalığı olan yaşlılarda iskemik inme riskini artırır.
İki Farklı İmplant-Dayanak Bağlantısına Sahip İmplantüstü Protezlerin Başarısının Değerlendirilmesi: Retrospektif Çalışma
Authors: GÖÇOĞLU Esra , TURKASLAN Suha
Published: April 2022

Amaç: Bu çalışma konik kilitli ve vidalı bağlantılı olmak üzere iki farklı implant-dayanak bağlantı tipine sahip dental implantların desteklediği (NTA, Toros Dental, Türkiye) implantüstü restorasyonlarda meydana gelen komplikasyon ve başarısızlıkların geriye dönük iki yıllık değerlendirilmesini amaçladı.Materyal-Metot: 2018-2020 yıllarında, toplam 75 hastaya uygulanan 290 adet dental implantın osseointegrasyon sonrası yapılan toplam 126 implantüstü restorasyon çalışmaya dahil edildi. Hastalar altı aylık aralıklarla kontrole çağırılarak klinik değerlendirmeler ile restorasyonlarda meydana gelen komplikasyonlar kaydedildi. Uygulanan protetik restorasyon tipleri; tek kron, sabit bölümlü köprü ve overdenture protezler olarak, protetik restorasyon materyal tipleri ise; metal seramik restorasyonlar, zirkonyum destekli seramik restorasyonlar ve metal akrilik rezin restorasyonlar olarak kaydedildi.Bulgular: Farklı implant abutment bağlantısına sahip implantlar ile restore edilen 75 hastada yapılan klinik değerlendirmeler sonucu; konik kilitli bağlantılı implant üstü protetik restorasyonlarda meydana gelen komplikasyonlar; sabit restorasyonlarda meydana gelen retansiyon kaybı (4, %5,6), overdenture protezlerin tutucularında oluşan retansiyon kaybı (2, %2,8), veneer seramiği kırığı (6, %8,5) olarak belirlendi. Vida bağlantılı implant üstü protetik restorasyonlarda meydana gelen komplikasyonlar; sabit restorasyonlarda meydana gelen retansiyon kaybı (10, %8,2), overdenture protezlerin tutucularında oluşan retansiyon kaybı (2, %3,6), veneer seramiği kırığı (5, %9,1), altyapı kırığı (1, %1,8), akrilik kaide kırığı (2, %3,6) olarak belirlendi. Vida bağlantılı implant üstü protetik restorasyonlarda görülen başarısızlık oranı %36,3, konik kilitli bağlantılı implant üstü protetik restorasyonlarda görülen başarısızlık oranı %16,9 olarak tespit edildi.Sonuç: İmplant üstü protetik restorasyonların komplikasyon veya başarısızlık oranları değerlendirildiğinde; konik kilitli bağlantılı implant üstü protetik restorasyonların vida bağlantılı implant üstü protetik restorasyonlardan daha başarılı olduğu görüldü.
Монгол хэлний нэрийн бүлгийн задлуурыг модны сангаас үүсгэх нь
Authors: Алтангэрэл Ч. , Энхжаргал Д. , Пүрэвсүрэн Б. , Золжаргал М. , Баярцацрал Ч. , Оюундарь Н.
Published: April 2022

Өгүүлбэрийн бүлгийн задлал нь өгүүлбэрийн гишүүдийг дэд бүлэгт (нэрийн, үйлийн болон бусад) хуваадаг үйлийг хэлдэг. Үүнийг хийдэг хэрэгсэл нь эх хэл боловсруулалтын үндсэн суурь хэрэгслүүдийн нэг бөгөөд үүний дотор нэрийн бүлгийн задлуур нь бичвэрээс нэр томьёо, мэдээлэл, мэдлэг гарган авах болон машин орчуулга зэрэгт хэрэглээ, ач холбогдол ихтэй, чухал хэрэгсэл юм. Энэхүү ажлаар тэмдэглэгээт модны сангаас нэрийн бүлгийг ялгаж нэрийн бүлгийн хөмрөг үүсгэх, түүн дээр сургасан нэрийн бүлгийн таниур загварыг үнэлэх, улмаар нэрийн бүлгийн сайн чанартай хөмрөг үүсгэх боломжийг судаллаа. Модны сангаас автоматаар үүсгэсэн нэрийн бүлгийн хөмрөгт тулгуурлан 89% нарийвчлалтай ажиллах нэрийн бүлгийн задлуурын загварыг гаргаж авлаа.
Characteristics and Concentration of White Dust and The Particulate Matter (PM10) in Erdenet city, Mongolia
Authors: Lkhagvajargal B. , Batdelger B. , Sonomdagva Ch. , Bayarbat B. , Atsushi M.
Published: April 2022

The purpose of this research was to determine characteristics and composition of white dust in the tailings pond of Erdenet Copper Mining (ECM) and to identify mass concentration of the particulate matter (PM10) around Erdenet city. Based on these goals, we determined critical level of flaring speed for white dust and how to reduce this speed. Meteorological data and particulate matter (PM10) were collected from the Research Institute of Meteorology, Hydrology and Environment (IRIMHE) and Air Quality Monitoring Station (AQMS) in Erdenet city. The mass concentration of par-ticulate matter (PM10) were analyzed and compared with WHO guidelines and Mongolian air quality standard (MNS4585:2016). Critical speed of flaring was tested in the laboratory condition and based on that we had estimated total number of days that white dust released into the air. In addi-tion, in order to reduce flaring white dust, watering method was tested in the laboratory and based on that the moisture amount to avoid flaring of white dusts had estimated. Results were shown that spring and autumn have a significantly higher level of mass concentration of PM10 in Erdenet city. It was caused by the stagnant atmosphere which leads to pollution’s cumulative effect and white dust from the storage of tailings pond during spring and autumn. Particle size of white dust had two types, 2-0.05 mm sandy and 0.05-0.002 mm dusty; yet it had a high concentration of As, Pb, Zn and Cu that were higher than the Mongolian national standard of heavy metals for soil. The critical level of flaring speed was about 4-5 m/s. Based on this critical level of flaring speed for white dust, on average 25 days per month had flaring white dust. The test result in the laboratory was shown that 5 percent of moisture would reduce the flaring
Голын эргийн зурвас газрын хамгааллын аргуудыг өртөг-өгөөжийн шинжилгээ ашиглах үнэлэх нь
Authors: Баянжаргал Д. , Хулан М. , Энхбилэг Д.
Published: April 2022

Номхон далайн ай савд хамаарах Онон, Улз, Халх голын сав газар усан сүлжээ сайтай, таг, тайга, ойт хээр, хээр талын ландшафтыг агуулдаг, Сибирь, Монгол, Манжуурын гаралтай амьтны зүйл харилцан нэвтрэлцсэн,Төв ази, Зүүн ази болон Өрнө Номхон далайн зэрэг дэлхийн нүүдлийн шувуудын томоохон 3 зам дайрч өнгөрдөг төдийгүй дэлхийн хамгаалах шаардлагатай экобүс болох Амар мөрний савд хамрагддагаараа монгол орны жигүүртний зүйлийн бүрдэл, олон янз байдал ялангуяа, ховордсон шувуудын амьдрах орчны хамгаалалд маш сонирхолтой нутаг юм.Иймээс нүүдлийн шувуудын хувьд монголд төдийгүй дэлхийд нийтийн анхаарлын төвд байдаг тогорууны төрийн 4 зүйл (хархираа тогторуу Grus grus, цагаа тогторуу G.leucogeranus, цэн тогторуу G.vipio, хар тогторуу G.monacha), 1 зүйл галуу ( хошуу галуу Anser cygnoides) болон 1 зүйл тоодгийн (хонин тоодог Otis tarda) амьдрах орчныг шувуудад чухал нутаг, ус намгархаг газрын нэг Улз голын эргийн дагуух газрыг хамгаалснаар эдгээр 6 зүйл шувуу хавар ирж өндөглөн зусах таатай орчныг бий болгох боломжтой юм. Энэ нь шувуудыг цаашид тогтвортой байршуулж, тоо толгойг нэмэгдүүлэх томоохон арга хэмжээ болох төдийгүй түүнийг дагасан олон улсын судалгаа шинжилгээний төв бааз, байгаль-шувуу ажиглах, сонирхох фото сафари аялал жуулчлалыг хөгжүүлэхийн зэрэгцээ тодорхой газрыг малын хөлөөс чөлөөлснөөр талхигдсан хөрс, ургамлын зүйлийн бүрдэл, олон янз байдлыг сэргээх нөхцлийг бүрдүүлэх зэрэг ач холбогдолтой. Мөн усан болон хуурай газрын холбоос болсон голын эрэг, татмын нугын чухал экостсемийг авран хамгаалах,тогтвортой амьжиргааг дэмжих олон талын эерэг үр дүн бий болох боломжит нутаг юм.Голын эргийн татмын хамгааллыг хийхдээ боломжит 2 хувилбарыг дэвшүүлэн шаардагдах өртөг зардлууд болон ирээдүйд татмын хамгааллаас бий болох биологийн болон эдийн засгийн үр өгөөжийг өртөг-өгөөжийн шинжилгээ (CBA) ашиглан тооцоолсон болно. Хувилбар тус бүрээр хамгааллын арга хэмжээний ирээдүйн үр өгөөж нийт өртгөөс өндөр байгааг CBA –ний гол үзүүлэлтүүдээр илрүүллээ. Үнэлгээний үр дүнгээс хамгааллын 1-р хувилбар нь NPV өндөр тодорхойлогдсан ба өөрөөр хэлбэл хамгааллын бүс нутгийн дагууд мод, бутлаг ургамал тарьж ойн зурвас үүсгэж малын хөлөөс хамгаалах нь урт хугацаанд биологийн олон янз байдалд тогтвортой эерэгээр нөлөөлж экологийн үр өгөөжийг нэмэгдүүлэх боломж байгааг харууллаа.
Freeport education diplomacy with AMINEF in promoting gender equality specifically for Papuan women
Authors: Danomira Bernadus Melkianus , Safirah Zakiah Nuril
Published: April 2022

Freeport Indonesia's mission is to be committed to being creative in processing the transformation of natural resources to provide prosperity and contribute to aspects of sustainable development through various mining practices by prioritizing the welfare and peace of employees and communities, human resource development, social and environmental responsibility, as well as safety and welfare in the operating area. The paper aims at identifying the Education Diplomacy of PT. Freeport Indonesia with AMINEF in improving gender equality in Papua and to analyze the barriers faced by women especially Papuan Women in taking part of the AMINEF scholarship specifically the Community College Initiative Program. The method used in this research is descriptive qualitative, by selecting interview techniques and literature study in data collection, as well as using the theory of Education Diplomacy, Multinational Corporation, and Gender Equality as theoretical framework on the whole process of implementing the AMINEF program in facing obstacles in achieving gender equality in Papua. The result of the research reveals that there has been no gender equality policy among three actors: the government, Freeport, and AMINEF which leads to low capability of developing Papuan people. Freeport itself merely concentrates on its production without paying attention on gender equality.
The City of Banda Aceh's planning and budgeting in regional work units: Are they gender responsive?
Authors: Ulfa Widya , Zainuddin Muslim , Khalil Zakki Fuad , Muazzinah Muazzinah , Nashriyah Nashriyah
Published: April 2022

Gender Responsive Planning and Budgeting (PPRG) is an instrument to overcome the gap in access, participation, control and benefits between women and men in the implementation of development to realize a more equitable budget. The implementation of the PPRG policy in every Banda Aceh City Apparatus Work Unit (SKPK) is still lacking in scope so that development from a gender perspective cannot be realized properly. This study aims to examine how the process and mechanism of PPRG and to find out the inhibiting factors in the Banda Aceh SKPK based on the Banda Aceh Mayor Regulations No. 18 of 2018 concerning Guidelines for the Implementation of PPRG for SKPKs. Using a qualitative method with a descriptive approach to examine primary data obtained by interview and observation techniques and secondary data by literature. The results show that the process of implementing the PPRG in the Banda Aceh SKPK only began with the issuance of policies as the legal regulation for implementation, provision of disaggregated data and technical guidelines. Then the stage of socialization and assistance in the preparation of the PPRG which produces examples of GAP and GBS where these two things are tools for integrating gender in planning documents. The inhibiting factors are the limitations of human resources and budget, there is no strong pressure in leadership, employee transfers to changes in nomenclature.
Religious development and child personality: What does religious psychology say about them
Authors: Wati Salmi , Amelia Rezki , Hidayatina Hidayatina , Gusmirawati Gusmirawati
Published: April 2022

This research aims to reveal how religious guidance in the formation of Islamic personality in children is seen from the study of religious psychology. Basically, personality and religious development in childhood is the responsibility of parents at home and teachers at school. So that the development can run as it should and can produce the expected results, it should be in an effort to foster the personality and religion of a child adjusted to his religious nature and religious development that is being passed. The research method used in this research is library research. By using descriptive analysis methods by collecting data, compiling or classifying, analyzing, and interpreting it. The results showed that the period of children is the beginning of religious coaching and personality. If the child's personal development is carried out properly, then in adolescence will not have difficulty in building his personality. Conversely, if the child fares poorly, where personal coaching in his family is not carried out properly and in school is less helpful, then he will face a difficult adolescence and his personal coaching will be very difficult.
Discrete-time Contraction Constrained Nonlinear Model Predictive Control using Graph-based Geodesic Computation
Authors: Wei Lai , McCloy Ryan , Bao Jie , Cranney Jesse
Published: April 2022

Modern chemical processes need to be operated around different operating
conditions to optimize plant economy, in response to dynamic supply
chains. As such, the process control system needs to handle a wide range
of operating conditions whilst optimizing system performance and
ensuring stability during transitions. This article presents a
reference-flexible nonlinear model predictive control approach using
contraction based constraints. Firstly, a contraction condition that
ensures convergence to any feasible state trajectories or setpoints is
constructed. This condition is then imposed as a constraint on the
optimization problem for model predictive control with a general
(typically economic) cost function, utilizing Riemannian weighted graphs
and shortest path techniques. The result is a reference flexible and
fast optimal controller that can trade-off between the rate of target
trajectory convergence and economic benefit (away from the desired
process objective). The proposed approach is illustrated by a simulation
study on a CSTR control problem.