bluuebunny/crossref_metadata_2025 huggingface dataset:
Predicting Choice Behaviour in Economic Games using Gaze Data Encoded as Scanpath Images
Authors: Byrne Sean Anthony , Reynolds Adam Peter Frederick , Biliotti Carolina , Bargagli-Stoffi Falco , Polonio Luca , Riccaboni Massimo
Published: October 2022

Eye movement data has been extensively utilized by researchers interested in studying decision-making within the strategic setting of economic games. In this paper, we demonstrate both a deep learning and traditional machine learning classification method which are able to accurately identify a given participant's decision strategy before they commit to an action while playing games. Our approach focuses on creating scanpath images that best capture the dynamics of a participant's gaze behaviour during a given game in a way that is meaningful to the machine learning models. Our results demonstrate a higher classification accuracy compared to traditional methods of analysis applied to the same economic game environments by as much as 18 percentage points. In a broader context, we aim to illustrate the potential for eye-tracking data to create information asymmetries in strategic environments in favour of those who collect and process the data. These information asymmetries could become especially relevant as eye-tracking is expected to become more widespread in user applications, with the seemingly imminent mass adoption of virtual reality systems, and the development of devices with the ability to record eye movement outside of a laboratory setting.
A low computation detection method of signal nonlinear distortion based on digital quadrature detection principle
Authors: WANG Pengcheng , Huang Xiaoping
Published: October 2022

This paper presents a digital low computation detection method for signal nonlinear distortion. After presetting ADC sampling rate and completing data sampling, the low sampling rate data extracted from the sampling data completes the autocorrelation analysis to correct and calculate the accurate fundamental frequency. According to the relationship between the fundamental frequency and the sampling rate, the complete periodic segment data of the signal cutting out from the sampling data carries out the digital orthogonal detection operation to obtain the value of each harmonic component and nonlinear distortion. Experiments show that the calculation of this method is less than that of FFT spectrum analysis method when measuring the THD lower than 15 order. When calculating the 15 order THD at 1024 points, the calculation time is reduced by 44.26%. Moreover, the digital quadrature detection method has high measurement accuracy with less than 0.6% error of detecting 5th order THD.
Use of Noise Prediction Models for Road Noise Mapping in Locations That Do Not Have a Standardized Model: a Systematic Review
Authors: Meller Gabriela , de Lourenço Willian Magalhães , de Melo Viviane Suzey Gomes , Grigoletti Giane de Campos
Published: October 2022

Faced with the accelerated growth of cities and the consequent increase in the number of motor vehicles, urban noise levels, caused by vehicular traffic, have increased considerably. In order to assess noise levels in cities and to successfully implement noise control measures or to identify the location of the problem in different urban areas, it is first necessary to obtain information on the noise levels to which people are exposed. Noise maps are tools that have several potential applications as they are cartographic representations of the noise level distribution in area and over a period of time. This article aims to identify, select, evaluate and synthesize information, through a Systematic Literature Review, on the use of different road noise prediction models, in sound mapping computer programs in countries that do not have a standard noise prediction model. From a previous analysis of articles, the choice of topic was based on the identification of a variety of different models for predicting road noise in countries that do not have a standardized model for the use of sound mapping. The papers compiled by SLR showed that studies concentrated in China, Brazil and Ecuador, and that the most used traffic noise prediction models were the RLS-90 and the NMPB, and the most used mapping programs were SoundPLAN and ArcGIS with a grid size of 10 x 10 m. Most measurements were carried out during a 15 min period at a height from ground level of 1.5 m.
Recovery journey of schizophrenic patients in Chinese culture:A Qualitative Study of Experiences
Authors: Ma Min , Shi Zhidao , Chen Yanhong , Ma Xiquan
Published: October 2022

Background: Psychiatric recovery is an integration of clinical and psychosocial frameworks. Previous concepts of recovery have been derived from a Western individualistic cultural context. In contrast, Chinese culture is dominated by collectivism under Confucianism. Therefore the recovery journey of Chinese people with schizophrenia may differ from that of the West. This study examines the experiences of Chinese schizophrenics on their recovery journey to understand the impact of Chinese culture on recovery.
Methods: The researcher selected 11 schizophrenic patients for an in-depth interview. And the researcher used an interpretative phenomenological research method to analyze the data.
Results: Three themes were identified in this study: traumatic experiences, rooted in family, and recovery impetus, comprising nine sub-themes. "Responsibility to the family" and "relying on oneself" are the main drivers of recovery for patients with a Chinese cultural background. Some patients believe that taking care of themselves is an important way to ease the burden on their families and treat them well. So there is a link between 'responsibility to family' and 'reliance on oneself.
Conclusions: Chinese patients with schizophrenia experience significant traumatic experiences and profoundly interact with their families. Both patient autonomy and kinship contribute to the recovery journey, suggesting that the influence of both patient autonomy and kinship should be considered in services that promote recovery. Developing a Chinese cultural context for recovery is an essential issue for Chinese psychiatric rehabilitation services.
Using Big Data and Orthogonal Matching Pursuit Regression for Forecasting Worldwide Green House Gasses Emissions and Consumption
Authors: Malakouti Seyed matin
Published: October 2022

According to the World Resources Institute, the quantity of carbon dioxide generated per person is rising. Low levels of carbon dioxide gas are safe for humans to breathe, but long-term exposure to the gas has been associated with several health issues. On the other hand, this gas may impact the respiratory system if the concentration is high enough. Additionally, the neurological system is in danger. Carbon dioxide, a greenhouse gas, has many potential uses. On the other hand, if the pace of output in industrial units is not managed, it might lead to severe issues and high compensation costs. This study creates a machine learning model that can generate the high accuracy in the shortest period to calculate the Emissions of greenhouse gases produced globally per capita.
Profile of Positive Specific Immunoglobulin E to Aeroallergen among Sudanese Patients at Al-Rayan Laboratory from January 2019 to December 2020
Authors: Mohamedahmed Mohamed Hassan Osman , Salih Omaima Abdelmajeed Mohammed , Mustafa Alamin , Mohammed Hala Hamza Eltayeb , Hassan Malaz Elsadeg , Ahmed Rogaia Hasap Alrasoul
Published: October 2022

Introduction:
Aeroallergens are various airborne substances or inhalants, such as pollen, spores, and other biological or non-biological airborne particles that can cause allergic disorders. Inhalation or cutaneous contact with aeroallergens can trigger a release of proteins in the form of an allergic reaction on the skin and mucous membranes.
Methods: This study was a qualitative retrospective study conducted in the Al-Rayan lab in Khartoum state from January 2019 to December 2020. All records with positive specific IgE to aeroallergens have been collected from Al Rayan Laboratory center. The immunoblotting technique [Euroline food gulf (IgE)] detect the IgE antibody against specific aeroallergens
Result:. Ninety-nine participants were positive for the specific IgE test aeroallergens panel. Most of them were adults, and the mean age of the participants was 21.3 ± 16.3. The most prevalent aeroallergen was Timothy grass and Oak. Timothy grass was positive among (46.5%) of the patients, Cultivated rye, olive tree, and common ragweed were mainly positive in November. The test for Oak allergen came positive in November 2020, March 2020, and October 2019 with the respective percentages (64.3%, 85.7%,46.2%). The olive tree and common ragweed aeroallergen reactions came equally positive in November 2020 the most (57.1%). Moreover, the age of the participants was related to Dog and Horse aeroallergens. In addition to penicillium, children mainly tested positive for Dog, Horse aeroallergens at P values (< 0.05).
Conclusion:
This study demonstrates that the most common aeroallergens are Timothy grass and Oak, followed by cultivated rye.
Virtual reality intervention for psychotic disorders using 360-degree video - agile development of an easy to implement protocol
Authors: Mikkonen Kasperi , Salmijärvi Laura , Lindgren Maija , Kröger Heta , Karpov Boris , Manninen Marko , Wegelius Asko
Published: October 2022

Background
Virtual reality technologies have been utilized in the treatment of psychiatric disorders by offering means to practice challenging situations in a safe environment. In this case report, we describe the development of a novel and easy to implement virtual reality-based intervention protocol to treat paranoid ideations of individuals with psychotic disorders.
Method
360-degree videos were filmed with a head-mounted camera, simulating everyday social situations which people with paranoid delusions often find threatening. These situations included for example walking in a crowded street or visiting a grocery store. Five weekly sessions with a clinician were included in the treatment protocol, following a treatment manual and individualized case formulation. The patients were exposed to the simulations using a virtual reality-headset.
Results
The intervention was found feasible by the clinicians and was positively received by the first pilot patients. The only observed disadvantage was nausea and dizziness caused by specific video clips. 360-degree videos as stimuli for exposure were deemed suitable.
Conclusions
Developing novel forms of treatment which are easy to pilot and to implement in day-to-day clinical environment may bridge the gap between controlled studies and standard practice. As far as we know, 360-degree videos have not been previously used in the context of psychotic disorders and their utility in the treatment paranoid ideation appears promising. Based on this pilot, creating virtual reality treatment protocols is possible without excessive resources and without any specific technical know-how. The process of development and implementation is carefully laid out so this paper can be used as a manual for similar protocols.
Trial registration:
not applicable
Individualized Portal Pressure Gradient Threshold Based on Liver Function Categories in Preventing Rebleeding After TIPS
Authors: Xia Yifu , Tie Jun , Wang Guangchuan , Zhuge Yuzheng , Wu Hao , Xue Hui , Xu Jiao , Zhang Feng , Zhao Lianhui , Huang Guangjun , Zhang Mingyan , Wei Bo , Li Peijie , Wu Wei , Chen Chao , Tang Chengwei , Zhang Chunqing
Published: October 2022

Background:
The evidence in Portal pressure gradient (PPG) < 12 mmHg after transjugular intrahepatic portosystemic shunt (TIPS) for preventing rebleeding mostly comes from observations in uncovered stents era. Moreover, association between Child–Pugh classes and post-TIPS hepatic encephalopathy (HE) has indicated that tolerance of PPG reduction depends on liver function. This study aimed to investigate the optimal PPG for covered TIPS and explore the optimal threshold tailored to the Child–Pugh classes to find individualized PPG to balance rebleeding and overt HE. Methods: This multicenter retrospective study analyzed rebleeding, OHE, and mortality of patients associated with post-TIPS PPGs (8, 10, 12, and 14 mmHg) in the entire cohort and among different Child–Pugh classes. Propensity score matching (PSM) and competing risk analyses were performed for sensitivity analyses. Results: We included 2100 consecutively screened patients undergoing TIPS. In all patients, PPG < 12 mmHg reduced rebleeding after TIPS (P = 0.022). In Child–Pugh class A, none of the PPG thresholds were discriminative of clinical outcomes. In Child–Pugh class B, 12 mmHg (P = 0.022) and 14 mmHg (P = 0.037) discriminated rebleeding, but 12 mmHg showed a higher net benefit. In Child–Pugh class C, PPG < 14 mmHg had a lower rebleeding incidence (P = 0.017), and exhibited more net benefit than 12 mmHg. Conclusion: Different PPG standards may be required for patients with different liver function categories. A PPG threshold < 12 mmHg might be suitable for patients in Child–Pugh class B, while < 14 mmHg might be optimal for patients in Child–Pugh class C.
Development of a Novel Technique for Measuring the 3D Sloshing in Cylindrical Tanks
Authors: Tamir U. , KATSIR O. , Gendelman O. V. , Shimshi E.
Published: October 2022

A novel technique for measuring the fluid sloshing in an opaque cylindrical tank is presented. The proposed measuring technique is fast and low cost but still maintains a sufficient level of accuracy while offering multiple measuring points on the circumference of the tank. The method expands the number of measuring points significantly in comparison to most methods reviewed. In order to measure all points, a single camera is mounted above the tank pointing towards its center. Markers on the internal face of the tank are used to calibrate the non-linear pixels to-height ratio of the water level as captured by the camera. The technique is able to capture different sloshing flow regimes under lateral sinusoidal excitation: planar waves, swirling waves, as well as a chaotic motion.
Evaluation the effect of Gum Arabic as prophylactic agent against chemotherapy-induced oral mucositis in cancer patients: A clinical trial
Authors: khazzan Abdulrazzaq Yahya Al , Hasan Abdel-Wahab , Eltayib Ali Elbagir , Suliman Waheeb Saleem
Published: October 2022

Several of oral problems such as mucositis, dry mouth and dysphagia associated with cancer therapy have significant impact on the physical status, social, and psychological behavior of cancer patients to varying degrees. The purpose of this research was to investigate the effect of Gum Arabic to prevent chemotherapy-induced oral mucositis in cancer patients. A clinical trial was conducted for a total of 374 cancer patients (14-80 years of age). Patients were categorized into two groups; 190 in the study group and 184 in the control group. The study group, who received chemotherapy were given a dose of 30 grams per day Gum Arabic orally for six weeks, while the control group received only chemotherapy. Essential data concerning the patients were recorded, and the assessment of oral mucositis was carried out weekly for six weeks. This study showed a significant (P = 0.001) reduction in the incidence of chemotherapy-induced oral mucositis in the fourth week and in the sixth week (P = 0.002). This study concluded that the regular administration of Gum Arabic has beneficial effects for cancer patients against oral mucositis induced by chemotherapy. This work registered at ClinicalTrials.gov by the following Identifier number: NCT03348241.
The p.Pro2232Leu variant in the ChEL domain of thyroglobulin gene causes intracellular transport disorder and congenital hypothyroidism.
Authors: Siffo Sofia , Pio Mauricio Gomes , Martínez Elena Bueno , Lachlan Katherine , Walker Joanna , Weill Jacques , González-Sarmiento Rogelio , Rivolta Carina Marcela , Targovnik Héctor Manuel
Published: October 2022

Thyroglobulin (TG), the predominant glycoprotein of the thyroid gland, functions as matrix protein in thyroid hormonegenesis. TG deficiency results in thyroid dyshormonogenesis. These variants produce a heterogeneous spectrum of congenital goitre, with an autosomal recessive mode of inheritance. The purpose of this study was to identify and functionally characterize new variants in the TG gene in order to increase the understanding of the molecular mechanisms responsible for thyroid dyshormonogenesis. A total of four patients from two non-consanguineous families with marked alteration of TG synthesis were studied. The two families were previously analysed in our laboratory, only one deleterious allele, in each one, was detected after sequencing the TG gene (c.2359C > T [p.Arg787*], c.5560G > T [p.Glu1854*]). These findings were confirmed in the present studies by Next-Generation Sequencing. The single nucleotide coding variants of the TG gene were then analyzed to predict the possible variant causing the disease. The p.Pro2232Leu (c.6695C > T), identified in both families, showing a low frequency population in gnomAD v2.1.1 database and protein homology, amino acid prediction, and 3D modeling analysis predict a potential pathogenic effect of this variant. We also transiently express p.Pro2232Leu in a full-length rat TG cDNA clone and confirmed that this point variant was sufficient to cause intracellular retention of mutant TG in HEK293T cells. Consequently, each family carried a compound heterozygous for p.Arg787*/p.Pro2232Leu or p.Glu1854*/p.Pro2232Leu variants. In conclusion, our results confirm the pathophysiological importance of altered TG folding as a consequence of missense variants located in the ChEL domain of TG.
Comparison of clinical characteristics and pathologic complete response (pCR) rate after neoadjuvant chemotherapy in very young women and older women with breast cancer
Authors: Dou He , Liu Yu qi , Yu Ping yang , Zhu Yue , Li Fu cheng , Wang You yu , Chen Xing yan , Wu Qi qi , Xiao Min
Published: October 2022

Purpose Age has been confirmed to be a very aggressive biological factor and associated with poor prognosis of breast cancer (BC) patients, but the effect of pathological complete response (pCR) rate after neoadjuvant chemotherapy (NAC) is still controversial, with the development of time, young women breast cancer(YWBC) gradually into people's vision, the understanding of YWBC(≤35y) is scarce. This study compares and evaluates the clinical characteristics and pCR rate after NAC in YWBC and other age women with breast cancer.
Patients and methods We retrospectively analyzed the clinicopathological data, molecular subtypes, chemotherapy regimen, and pCR rates of 1424 non-metastatic BC patients from the Affiliated Cancer Hospital of Harbin Medical University from January 1, 2012, to December 31, 2019. Categorical data were compared using the chi-square test and Fisher's exact test for multivariate data using Logistic regression models. Any predictor variable with P <0.05 in the univariate analysis was included in the multivariate regression analysis to study the relationship between different age groups and pCR.
Results A total of 879 patients in this study were eligible for analysis, and 71(8.1%) female patients were ≤35 years old.YWBC were more likely to get pCR (25.4%vs15.6%, P= 0.033). The proportion of patients with a higher clinical stages was higher. Compared with elderly patients, YWBC patients were more likely to undergo breast-conserving surgery(BCS), multivariate analyses found similar results in different age groups, and more patients with Her-2 positive and triple-negative breast cancer (TNBC). In the whole group, Age, PR expression, HER-2 expression, KI67 expression, and clinical stage were the independent predictors of pCR after NAC in BC patients (P <0.05).
Conclusion Our study found that age is the main factor affecting the achievement of pCR in patients with BC. YWBC has a higher clinical stage and a high proportion of HER-2 positive patients, which is the leading cause of poor prognosis.YWBC has a higher effect on chemotherapy therapy. We need to pay more attention to this group and achieve individualized treatment, which will help us treat BC better and provide new targets and blueprints for our clinical therapy.
Metatarsal Stress Fractures: An Analysis of Readability and Quality of Online Health Materials
Authors: Hickey Olivia , Murphy Ben , Kiroplis Irene , Hidayat Yasir , D’Souza Lester
Published: October 2022

Background
Patients are increasingly accessing health information via the internet. Our aim was to assess the quality and readability of online patient education materials regarding metatarsal stress fractures. We hypothesised that this information would be too difficult for the average patient to read and of a lesser quality than desired.
Method
A search of the top 50 results on 3 search engines (Google, Bing, Baidu) was completed (MeSH “metatarsal stress fracture”, “metatarsal stress fractures”). Readability of these websites was calculated using www.readable.com, producing 3 scores: Gunning-Fog (GF), Flesch Reading Ease (FRE) and Flesch-Kincaid Grade (FKG). Quality of the retrieved webpages was analyzed using Journal of American Medical Association (JAMA) benchmark criteria and the Health On the Net (HON) code toolbar extension.
Results
77 unique websites were identified. The mean scores were: FRE 56.34+/- 16.1, FKG 8.36 +/- 2.8 and GF 9.35 +/-3.4. This corresponds with most webpages being pitched to a grade 8–12 reading level. Most webpages per the FRE score (n = 47, 61%) were pitched at a grade 10 reading level and above. The GF index identified 20 webpages (26%) aimed towards readers of a grade 7 level or below. 10 websites (13%) displayed a current HONcode certificate. Most websites (n = 35, 45.5%) didn’t meet any of the JAMA criteria.
Conclusion
This study uncovers the high difficulty and poor quality of online health materials relating to MSFs, potentially contributing to negative health outcomes. Given the relationship of health literacy and patient outcomes, it is vital that we address these deficiencies swiftly.
Community awareness, attitudes and patterns of use toward fish oil and cod liver oil in Ethiopia: A cross-sectional study
Authors: Sasie Sileshi Demelash , Abayneh Aschalew , Wodajo Berhanu , Kebede Mebratu Abraha , Aragaw Fantu Mamo
Published: October 2022

Background
- Nutrition has a significant impact on health throughout life. Despite the increased frequency of questions about dietary supplements and their availability, reports showed that the communities have little knowledge of dietary supplements. Fish oils and cod liver oil is the most widely used non-vitamin, non-mineral dietary supplements. The present study aimed to determine the knowledge, attitudes, and practice of the community towards dietary supplements such as fish oil and cod liver oil including some underlying factors in Ethiopia.
Method
- A cross-sectional multi-center study was conducted among the community in different cities of Ethiopia. Stratified random sampling was used to select a total of 900 community participants included in the study. The data was collected using an interview-administered questionnaire. Descriptive analysis was done using STATA software. Both bi-variable and multivariable logistic regression analysis was done.
Results
The overall knowledge, attitude, and practice of the community towards the usage of cod-liver oil or fish oil in this study was 65.04%, 62.26%, and 26.75% respectively. Participants living in Sidama and Oromo have 0.25 (AOR = 0.25:,95% CI: 0.07, 0.90) and 0.23 (AOR = 0.23:,95% CI: 0.06, 0.88), having an income level of < 3000 have 0.56 (AOR = 0.56:,95% CI: 0.30, 0.98) ) times higher odds of being knowledgable towards cod-liver oil and fish oil. Participants who have chronic illness were 3.27 (AOR = 3.27; 95% CI; 1.71, 6.23), times higher odds of practicing usage of cod-liver oil or fish oil than participants who have no chronic illness. Participants who were aged > 45 were 0.27 (AOR = 0.27; 95% CI; 0.06, 0.90), times higher odd of practicing usage of cod-liver oil or fish oil
Conclusion
The overall knowledge and attitude of the community were good, but their practice towards the usage of cod liver or fish oil was relatively low. Participants living in Sidama and Oromo and having an income level of < 3000 were significant predictors of knowledge of the community using cod-liver oil or fish oil. Participants living in Sidama and Oromo is one of the determinant factors for having a positive attitude towards the usage of cod-liver oil or fish oil. Participants who were aged > 45, and participants who have chronic illnesses were significant predictors of the practice of the community using cod-liver oil or fish oil.
Multiresolution approach on Medical Image Fusion by Modified Local Energy
Authors: Nair Rekha R , Babu Tina
Published: October 2022

Human and machine perception data that are not redundant are very important in the medical field for diagnosis and treatment. The proposed work fuses medical images to extract valuable necessary information from dissimilar images to a single image in the Wavelet domain using a novel Modified Local Energy(MLE) fusion rule termed ModifiedLocal Energy Image Fusion(MLEIF). The image edges are essential information points that are used to display a clear visual image structure. Modified Local energy helps to provide edge characteristics more clearly in the fusion outcome than a single pixel-based fusion rule. The denoising property of the local energy is the additional advantage of the proposed fusion. The similarity of the fused image with the source images is improved by B-Spline registration in the pre-processing stage. Finally, the fused image is created with all the corresponding coefficients by transforming the inverse wavelet. SVM-based contouring of the lesion part helps observes to identify the lesion part from the fused image. Carried out experiments on real-time and standard data sets with expert radiologist subjective evaluation and quantitative analysis by well-known non-reference performance measures.
Rotation and heat convection effects on double-diffusive peristaltic MHD Sisko nanofluid flow through a porous medium in presence of non-linear thermal radiation, heat generation/absorption, and Joule heating
Authors: Abo-Dahab S. M. , Mohamed R. A. , Abd-Alla A. M. , Soliman M. S.
Published: October 2022

This article includes a numerical study of the double-diffusive peristaltic flow of a non-Newtonian Sisko nanofluid through a porous medium inside a horizontal symmetric flexible channel under the influence of Joule heating, nonlinear thermal radiation, viscous dissipation, and heat generation/absorption in presence of heat and mass convection, considering effects of the Brownian motion and the thermophoresis coefficients. On the other side, the long wave approximation was used to transform the nonlinear system of partial differential equations into the nonlinear system of ordinary differential equations which were later solved numerically using the fourth-order Runge-Kutta method with shooting technique using MATLAB program code. The effects of all physical parameters resulting from this study on the distributions of velocity, temperature, solutal concentration, and nanoparticles volume fraction inside the fluid were studied in addition to, a study of the pressure gradients using the 2D and 3D graphs that were made by the MATLAB program in addition to, studying the impact of some parameters on the behavior of the streamlines graphically within the channel with a mention of their physical meaning. Finally, some of the results of this study showed that the effect of Darcy number 𝐷𝑎 and the magnetic field parameter 𝑀 is opposite to the effect of the rotation parameter 𝛺 on the velocity distribution whereas, the two parameters non-linear thermal radiation𝑅and the ratio temperature 𝜃𝑤works on a decrease in the temperature distribution and an increase in both the solutal concentration distribution and the nanoparticle's volume fraction. On the other hand, the effect of the rotation parameter 𝛺 on the distribution of pressure gradients was positive, and the effect of both Darcy number 𝐷𝑎 and the magnetic field parameter 𝑀on the same distribution was negative.
Real-Time Process Evaluation of a Participatory Intervention with Healthcare Workers
Authors: Chin Winnie Szu Yun , Rice Serena , Morocho Cesar , Kurowski Alicia , Punnett Laura
Published: October 2022

Background

Participatory organizational interventions engage workers to improve their own workplace health and safety. Process evaluation helps to avoid expensive missteps and to explicate how and why these interventions succeed or fail. Periodic measurements of attendance and time devoted to program activities are component measures of intervention dose. Participant appraisals of the process (usability) can detect problems and facilitate improvements in real time. This study describes process metrics to evaluate intervention dose, reach and usability in a participatory workplace change study.

Methods

The “Safety and Health through Integrated Teams” (SHIFT) study used a stepped-wedge design in five healthcare facilities, randomized into immediate- and lagged- intervention groups. Joint labor-management health and safety “Design Teams” (DT) were recruited at each site. Immediate intervention sites were coached to use the Healthy Workplace Participatory Program (HWPP): conduct root cause analysis of a health or safety problem, brainstorm solutions, and compile them into intervention packages. At all sites, we tracked attendance and time in meetings of DTs, co-facilitators with the coach, and leadership Steering Committees; participants’ opinions of meetings and program materials; and program activities with time spent outside of meetings.

Results

During the coached period, average attendance at all meetings was 74% of expected individuals per meeting (n = 90), while the uncoached meetings (n = 12) averaged 57%. Across the study period (both uncoached and coached meetings), most DT members reported understanding the meeting purpose, speaking up and having their opinions considered, that facilitators were effective, and discussion was meaningful for health and safety goals. Co-facilitators in the coached period, compared to the uncoached period, reported not enough time during phase 1 (p = 0.053) and more difficulty facilitating later implementation steps (phase 2) than the initial ones (phase 1) (p = 0.029). As the implementation advanced, DT members reported speaking up and giving their opinion more in phase 2 than phase 1 (p = 0.009).

Conclusions

The SHIFT intervention coaching appeared to support high meeting attendance, equal participation and consideration of opinions between managerial and non-managerial personnel. Recording of process outcomes throughout the intervention process helped to identify steps where Design Teams needed assistance, which was essential for a successful participatory program.
Trial registration: ClinicalTrials.gov NCT04251429 (retrospectively registered January 29, 2020).
The novel fluorescent probe toward yttrium(Ⅲ) and its bioimaging
Authors: Qin Yuxin , Meng Qian , Yao Junxiong , Chen Mengyu , Dong Yajie , Chen Dashuo , He Shuping , Bai Cuibing , Zhang Lin , Wei Biao , Miao Hui , Qu Changqing , Qiao Rui
Published: October 2022

In this paper, the novel fluorescence probe XP based on Schiff-base was designed, synthesized and characterized, which could detect Y3+selectively and sensitively. The recognition mechanism of XP toward Y3+ was studied by Job's plot and HRMS. It was investigated that stoichiometric ratio of the probe XP conjugated with Y3+ was 1:2. And the detection limit was calculated as 0.30 µM. In addition, Y3+ was recognized by the test paper made from XP. And the probe XP could selectivity toward Y3+ in Caenorhabditis elegans and the main organs of mice. Thus, XP was considered to have some potential for application in bioimaging.
On the stability & phase locking to a system reference of an optoelectronic oscillator with large delay
Authors: Hasan Mehedi , Nicholls Charles , Hall Trevor
Published: October 2022

Delay line oscillators based on photonic components, offer the potential for realization of phase noise levels up to 3 orders of magnitude lower than achievable by conventional microwave sources. Fibreoptic-based delay lines can realize the large delay required for low phase noise systems whilst simultaneously achieving insertion loss levels that can be compensated with available microwave and photonic amplification technologies. Multimode operation is an artefact of the delay line oscillator and introduces modulational instability into phase-locked control loops. An optoelectronic oscillator (OEO) with large delay under proportional integral control by a phase-locked loop (PLL) is modelled, providing the first report of the location of all the infinity of poles of the PLL-OEO system function. The first experimental observation of giant phase modulated oscillation of a free OEO and spontaneous giant phase modulated oscillation of a PLL-OEO are also reported and explained respectively as a source and manifestation of modulational instability. Nevertheless, the analysis and experimental observations, including a prototype 10 GHz PLL-OEO phase noise spectral density achieving −𝟖𝟎 𝒅𝑩𝒄⁄𝑯𝒛 𝐚𝐭 𝟏𝟎 𝑯𝒛 and −𝟏𝟒𝟓 𝒅𝑩𝒄⁄𝑯𝒛 𝐚𝐭 𝟏𝟎 𝒌𝑯𝒛, demonstrate that stable phase lock operation and optimum phase noise performance is achievable provided full account of the multimode nature of the OEO is taken in the phase lock analysis.
Psoriasis and oral health in adult United Statues population: A cross-sectional study
Authors: Hussein Mai , Farag Youssef M.K. , Sonis Stephen
Published: October 2022

Objectives
The results were inconsistent with the association between psoriasis and periodontitis. To better understand the strength and nature of the association between oral conditions and psoriasis by analysis of a large number of adults in the United States.
Methods
By using The National Health and Nutrition Examination Survey datasets from 2009 to 2014, we performed a cross-sectional analysis. For participants aged ≥ 30 years, the psoriasis status was assessed from the medical questionnaire. We used data from periodontal and oral examinations to assess the oral conditions of our participants. We examined the association between psoriasis as exposure and moderate/severe periodontitis and non-functional dentition as outcomes.
Results
The weighted prevalence of psoriasis was 3%, 44% for moderate/severe periodontitis, and 20.5% for non-functional dentition. The fully adjusted model showed no significant association between psoriasis and moderate/severe periodontitis (Prevalence Ratio 1.03, 95% CI 0.9–1.2, p = 0.7). There was no statistically significant association between psoriasis and non-functional dentition except in the fully adjusted model it became statistically significant (Prevalence Ratio 0.8, 95% CI 0.7–0.9, p = 0.04).
Conclusion
Psoriasis was associated with the lower prevalence of non-functional dentition after adjustment of potential confounders but was not associated with the higher prevalence of moderate/severe periodontitis.
Usefulness of the combined orthodontic rubber band and clip method for gastric endoscopic submucosal dissection
Authors: Li Dazhou , Zheng Linfu , Zhang Zewen , Chen Longping , Jiang Chuanshen , Wang Rong , Lin Jiahong , Lu Yiwen , Bai Yang , Wang Wen
Published: October 2022

Background and Aims

Effective traction is an important prerequisite for successful endoscopic submucosal dissection (ESD). The combined orthodontic rubber band (ORB) and clip method was effective in colorectal cancer ESD. To date, the method was not reported in gastric ESD. This study aimed to investigate its efficacy and safety for gastric neoplasms ESD.

Methods

We retrospectively analyzed data of 118 patients with gastric neoplasms treated by ESD from November 2020 to April 2022, 43 by ORB-ESD and 75 by the conventional ESD. The primary outcome measure was the ESD procedure time. Clinical data on efficacy and safety were also collected and analyzed. Propensity score matching (PSM) matched the patients in both groups.

Results

PSM successfully matched 31 pairs of patients. The ORB-ESD operation time was shorter (median [interquartile range], 35 [30–48] versus 49 [40–70] min, P < 0.001) and dissection speed was higher (median [interquartile range], 22.6 [14.4–29.3] versus 13.5 [9.6–17.9] mm2/min, P < 0.001) than in the conventional ESD. The groups were similar in muscular injury rate, frequency and time of use of thermal hemostatic forceps, postoperative adverse events, en bloc resection, and R0 resection rate (P > 0.05).

Conclusions

Compared to the conventional ESD, ORB-ESD significantly reduced the procedure time and increased the dissection speed, proving beneficial to gastric ESD.
Acamprosate reduces ethanol intake in the rat by a combined action of different drug components
Authors: Ademar Karin , Nilsson Mathilda , Domi Ana , Adermark Louise , Söderpalm Bo , Ericson Mia
Published: October 2022

Alcohol misuse accounts for a sizeable proportion of the global burden of disease, and Campral® (acamprosate; calcium-bis-(N-acetylhomotaurinate)) is widely used as relapse prevention therapy. The mechanism underlying its effect has in some studies been attributed to the calcium moiety and not to the N-acetylhomotaurine part of the compound. We recently suggested that the dopamine elevating effect of acamprosate is mediated both by N-acetylhomotaurine and calcium in a glycine receptor dependent manner. Here we aimed to explore, by means of in vivo microdialysis, if systemic administration of the sodium salt of N-acetylhomotaurine (sodium acamprosate; 200 mg/kg, i.p.) enhanced the effects of calcium chloride (CaCl2; 73.5 mg/kg, i.p.) on nucleus accumbens (nAc) dopamine and/or taurine levels in male Wistar rats. In addition, we investigated if N-acetylhomotaurine potentiates the ethanol-intake reducing effect of CaCl2 in a two-bottle choice voluntary ethanol consumption model followed by an alcohol deprivation effect paradigm. Systemic administration of regular acamprosate, sodium acamprosate or the combination of CaCl2 and sodium acamprosate significantly increased extracellular dopamine and taurine levels in the nAc. CaCl2 alone instantly increased dopamine but the effect did not sustain throughout the entire measured time period and taurine levels were not altered. Ethanol intake was significantly reduced by systemic administration of CaCl2, but the addition of sodium acamprosate prolonged the calcium-induced reduction of ethanol intake. Neither treatment suppressed the alcohol deprivation effect. The data presented suggest that CaCl2 and N-acetylhomotaurinate act in concert both regarding elevation of extracellular nAc dopamine levels and in reducing ethanol intake.
Impact of health literacy and social support on medication adherence in patients with hypertension: a cross-sectional community-based study
Authors: Guo Aizhen , Jin Hua , Mao Jianbo , Zhu Weihong , Zhou Ye , Ge Xuhua , Yu Dehua
Published: October 2022

Background
Previous studies have associated health literacy and social support with medication adherence in hypertension. However, limited evidence exists regarding the mechanisms between the factors and medication adherence.
Purpose
To explore the prevalence of medication adherence and its determinants in patients with hypertension in Shanghai.
Methods
A community-based cross-sectional study was conducted containing 1697 participants with hypertension. We collected the characteristics of sociodemographic and clinical, the profiles of health literature and social support, and medication adherence using questionnaires and examined interactions among the factors using a structural equation model.
Results
The participants contained 654 (38.54%) with low medication adherence, and 1043 (61.46%) with medium/high adherence. Social support influenced adherence directly (β = 0.165, P < 0.001) and indirectly through health literacy (β = 0.087, P < 0.001). Health literacy directly influenced adherence (β = 0.291, P < 0.001). Education indirectly affected adherence through social support (β = 0.048, P < 0.001) and health literature (β = 0.080, P < 0.001). Moreover, there was a sequential mediating effect of social support and health literature on the association between education and adherence (β = 0.025, P < 0.001). After controlling for age and marital status, similar results were also obtained, indicating a good model fit.
Conclusions
Medication adherence of hypertensive patients needs to improve. Health literacy and social support had direct and/or indirect effects on adherence, which should be more consider as the measures of improving adherence.
Metabolic profiles and fingerprints for the investigation of the influence of nitisinone on the metabolism of the yeast Saccharomyces cerevisiae
Authors: Kostina-Bednarz Marianna , Płonka Joanna , Nowak Paulina , Barchanska Hanna
Published: October 2022

Nitisinone (2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione, NTBC) is considered a potentially effective drug for the treatment of various metabolic diseases associated with disorders of L-tyrosine metabolism however, side-effects impede its widespread use. This work aimed to broaden the knowledge of the influence of NTBC and its metabolites 2-amino-4-(trifluoromethyl)benzoic acid (ATFA), 2-nitro-4-(trifluoromethyl)benzoic acid (NTFA), and cyclohexane-1,3-dione (CHD) on the catabolism of L-tyrosine and other endogenous compounds in Saccharomyces cerevisiae. Based on a targeted analysis performed by LC-ESI-MS/MS, based on multiple reaction monitoring, it was found that the dissipation kinetics of the parent compound and its metabolites are compatible with a first-order reaction mechanism. The same mode of analysis was used to reveal that NTBC metabolites formed in the model organism cause a 15–59% decrease in L-tyrosine, L-tryptophan, and L-phenylalanine compared to the untreated model organism. The overall changes in the metabolism of yeast exposed to NTBC or its derivatives were evaluated by non-targeted analysis via LC-ESI-MS/MS in the ion trap scanning mode. Based on principal components analysis, a statistically significant similarity between metabolic responses of yeast treated with ATFA or NTFA was observed. These findings facilitate further studies investigating the influence of NTBC on the human body and the mechanism of its action.
Save our surgeons (SOS) – an explorative comparison of surgeons’ muscular and cardiovascular demands, posture, perceived workload and discomfort during robotic vs. laparoscopic surgery
Authors: Krämer Bernhard , Neis Felix , Reisenauer Christl , Walter Christina , Brucker Sara , Wallwiener Diethelm , Seibt Robert , Gabriel Julia , Rieger Monika A. , Steinhilber Benjamin
Published: October 2022

Purpose: Conventional laparoscopic surgery (CLS) imposes an increased risk of work-related musculoskeletal disorders. Technical innovations, such as robotic-assisted laparoscopic surgery (RALS), may provide ergonomic benefits. We compare the surgeon`s work-related demands of CLS vs RALS for benign hysterectomies.
Methods: Five specialists (3 females, 2 males) each performed four RALS and four CLS as part of their daily clinical routine. During the surgical procedures, muscular demands were assessed by bipolar surface electromyograms of the descendent trapezius, extensor digitorum and flexor carpi radialis muscles as well as cardio-vascular demands by electrocardiography, and neck, arm and torso posture by gravimetrical position sensors. Additionally, the subjects rated their level of perceived workload (NASA TLX questionnaire with 6 dimension) and musculoskeletal discomfort (11-point Likert-scale, 0-10).
Results: Muscular demands of the trapezius and flexor carpi radialis muscles were lower with RALS but extensor digitorum demands increased. Cardiovascular demands were about 9 heart beats per minute (bpm) lower for RALS compared to CLS with a rather low median level for both surgical techniques (RALS = 84 bpm; CLS 90 bpm). The posture changed in RALS with an increase in neck and torso flexion, and a reduction in abduction and anteversion position of the right arm. The perceived workload was lower in the physical demands dimension but higher in the mental demands dimension during RALS. Subjective musculoskeletal discomfort was rare during both surgical techniques.
Conclusions: This explorative study identified several potential ergonomic benefits related to RALS which now can be verified by studies using hypothesis testing designs. However, potential effects on muscular demands in the lower arm extensor muscles also have to be addressed in such studies.
Electrochemical Biosensor to Detect Implant Derived Metal Ions: A Mice Model
Authors: Gokul Deeptha , Catton Eniola , Cheng Kai Yuan , Mathew Mathew
Published: October 2022

Joint replacement surgeries are progressing at an increased rate in the United States, with around 1 million surgeries being performed annually. While these orthopedic implants provide a solution for a damaged joint, debris such as metal ions generated due to the wear and corrosion of the implants prove to be of considerable risk of systemic and local toxicity. As an effective diagnostic tool, there is a need to develop a patient-friendly, cost-effective, and rapid mode of metal ion detection in orthopedic patients with various implants. In this study, an electrochemical biosensor chip (Dropsens) is proposed as a diagnostic tool to detect metal ions through changes in impedance. In vivo studies were conducted using CoCrMo particles intra-particularly injected into mice. Then, blood was collected on 0th day, 14th day, and 28th day after injection and was centrifuged to obtain serum. The serum was subject to various electrochemical techniques such as Electrochemical Impedance Spectroscopy (EIS) and cyclic voltammetry (CV). Additionally, standardization experiments were performed using different concentrations of CoCrMo wear particles suspended in PBS and mice serum. The EIS standardization experiments reveal a negative correlation between impedance (Rp) value obtained after fitting with the equivalent CPE model and metal ion concentration in mice serum. A regression equation was obtained from the standard experiments. The CV data for differing metal ion concentrations and the regression equation were also obtained. The mice model data, the bode plot which depicts the change in impedance and phase angle at each frequency, the positive control group shows the highest impedance at any frequency followed by the experimental 28th day mice serum. The % change in impedance between the different groups revealed the increasing presence of metal ions in serum on 28th day. The CV experimental data obtained reveal a possible correlation between CV area and metal ion concentrations. Experimental mice models were established to mimic the possible diffusion of metal particles from implants. Dropsens electrochemical biosensors were efficiently employed to detect metal ions in serum through changes in impedance.