bluuebunny/crossref_metadata_2025 huggingface dataset:
Avaliação e aprimoramento do sistema de água quente em moradia universitária: Um exemplo de intervenção
Authors: Emanuel Rodrigues da Silva Rodrigo , Martins de Paula Heber , De Pádua Castro Metsavaht Yan
Published: September 2024

A utilização de sistemas de aquecimento solar de água pode trazer economia, diminuindo impactos ambientais em comparação com fontes convencionais de energia. O objetivo principal do trabalho foi identificar patologias no sistema predial de água quente da Moradia Universitária do Cerrado (MUC) em Catalão-GO, e corrigi-las por meio de intervenções, avaliando a eficiência antes e após. Durante catorze meses, foram coletados dados do consumo de água fria, água quente, e energia dos apartamentos e do número de moradores do edifício. Na intervenção houve substituição da tubulação de CPVC por tubos de PEX, mudança nas interligações das placas, introdução de bomba hidráulica e válvulas para melhorar a recirculação, e a troca da resistência elétrica.  Após as modificações, houve uma tendência de redução no consumo total de água quente e no índice de consumo (IC). O tempo médio de aquecimento dos chuveiros foi reduzido de 2 minutos para 20 segundos. Além disso, o consumo médio de água quente por morador diminuiu em 23,47%. O consumo de energia, que apresentava uma tendência de aumento, estabilizou-se após as modificações, indicando uma melhoria na eficiência energética do prédio. Assim, as intervenções contribuíram para aumentar a eficiência das instalações.
Em busca do arquiteto perdido
Authors: Mello Bruno Cesar Euphrasio de , Fischmann Daniel Pitta
Published: September 2024

A Faculdade de Arquitetura (FA) da UFRGS iniciou suas atividades em 1952. Embora seu processo de criação tenha sido abordado por diversos trabalhos, poucos tomaram sua construção como objeto de debate. Portanto, permanecem lacunas no conhecimento sobre o edifício. A principal delas: quem desenhou o FA? Este artigo aborda: (a) o debate travado nos órgãos da FA que deu origem à construção do edifício; (b) projetos não construídos; c) o papel desempenhado pela Comissão designada para a elaboração do projeto construído; e (d) o nome do provável autor do projeto da FA. O artigo está dividido em quatro partes: fontes e métodos; o processo de construção do edifício da FA; a provável autoria do projeto; e considerações finais. Após o exame de todo o processo que culminou na inauguração do edifício, nos perguntamos: terá sido esse um projeto autoral, passível de atribuição a um único profissional? Ou seu resultado é a forma possível dentro de uma complexa e intrigante cadeia de eventos?
From a Distance: A Model to Onboard and Support Undergraduates Doing Research
Authors:   Texas A&M University, Bloom Rosaleen Duggan , Kaseda Erin T. ,   Rosalind Franklin University of Medicine and Science, Gandelman Erin M. ,   Rosalind Franklin University of Medicine and Science, Miller Steven A. ,   Rosalind Franklin University of Medicine and Science, Bitterman J. Benjamin ,   Lake Forest College, Namuhmuh Kate ,   Texas State University
Published: September 2024

In this article the authors describe a model for onboarding and supporting undergraduates during a multisite research project. Undergraduate students had hands-on experiences conducting social media research focused on adolescent and young adult cancer patients and their caregivers. The research was conducted across multiple sites using online platforms and students were onboarded online and worked remotely. Mentoring undergraduates in research is an essential faculty responsibility. However, research involving sensitive topics such as cancer can be emotionally difficult. Students were mentored throughout the project by faculty with regularly scheduled weekly or biweekly meetings. Mental health resources were provided to support students with the difficult experiences they were studying. Students and faculty described how they benefited from this research experience, including lessons learned from each other.
Improving environmental literacy through the development of problem-based learning models that incorporate local wisdom
Authors: Lubis Silvi Puspa Widya Lubis , Suryadarma Gusti Putu , Paidi  , Yanto Bagus Endri
Published: September 2024

This study aimed to determine the validity of the problem-based learning with local wisdom in Acehnese oriented to socio-scientific issues to improve students' environmental literacy, and to find out the practicality of the problem-based learning with local wisdom oriented to socio-scientific issues model, to improve students' environmental literacy. This research used the design of developmental research stages according to Branch that consists of Define, Design, Develop, Disseminate (4D). Data collection was conducted by using instruments in the form of tests, questionnaire sheets, and product validation sheets. The data was analyzed by adopting qualitative data with content analysis techniques and quantitative data were analyzed with descriptive statistics. The results showed that problem-based learning with local wisdom oriented to a socio-scientific issues model was proven to have a level of validity and practicality to improve students' environmental literacy. This study concludes that the design of problem-based learning with local wisdom oriented to socio-scientific issues models and its supporting tools are feasible to use to improve students' environmental literacy skills with good categories.
 Keywords: Environmental literacy; local wisdom; problem-based learning; socio-scientific issue
Psychoactive Drug Use in Sport
Authors: McLean Katherine
Published: September 2024

The spectacle of illicit drug use or doping among high-profile athletes has become a staple feature of news outlets worldwide. Beyond carrying implications for competition results, titles, and sport-specific records, such cases are read as compelling morality tales, and consumed as popular entertainment. In fact, there is little evidence that athletes’ consumption of controlled substances has increased over time, or represents a new problem; yet perception has shaped substance use policies in both sport and society at large – making and breaking careers, fueling fears, and generating unanticipated consequences. This book presents a broad epidemiological portrait of psychoactive drug use among athletes, bolstered by a theoretical framework that highlights salient sociological features of sport and the social psychology of athletic teams and competition. Sport at all levels is explored as a “risk environment” for drug use, which serves to modulate not only the likelihood of psychoactive substance use, but the associated harms. Interventions, policy options, and sporting contexts that may reduce or minimize drug-related harms, or encourage controlled substance use, are considered throughout the text. In addition to sketching a global history of psychoactive drug use in sport, two drug-specific case studies are presented in detail: alcohol use and overuse among university and non-elite “club” athletes, and the non-medical consumption of opioids within contact sports. An interdisciplinary text, this book provides a comprehensive review of current research in psychoactive drug use in sport, as well as a guide to evidence-based interventions.
Festividades religiosas no antigo oriente próximo: um estudo comparativo entre o festival de akitu e o yom kippur
Authors: Galvão Eloá Moura
Published: September 2024

O presente artigo tem como objetivo realizar um estudo comparativo entre dois dos principais festivais/eventos realizados no Antigo Oriente Próximo do qual existem registros históricos e bíblicos: o festival de Akitu e o Yom Kippur. O festival de Akitu era uma das principais festividades na Mesopotâmia tendo início no primeiro dia do ano e procurando alcançar diversos objetivos, sendo eles religiosos e políticos. No entanto, o festival de Akitu deixou de ser celebrado por vários séculos, ao passo que o Yom Kippur continua sendo celebrado ou lembrado pela religião judaica ainda atualmente. Diante disso surge a problemática: Quais eram as principais características do festival do Akitu? Existem semelhanças entre o festival de Akitu e a festividade judaica do Yom Kippur? O presente artigo irá discutir essas questões e argumentar que embora haja algumas similaridades entre esses dois antigos festivais, no fim os princípios e os propósitos que ambos os festivais pretendiam alcançar eram muito diferentes.
Intertextualidade bíblica em perspectiva: implicações e diretrizes de abordagem
Authors: Leite Paulo Alberto Barros , De Souza Elias Brasil
Published: September 2024

Esta pesquisa se propõe a estudar a Teoria da Intertextualidade, sua classificação, adoção e o desenvolvimento do termo dentro do campo da pesquisa bíblica, bem como suas implicações hermenêuticas. Ela abordavários modelos e diretrizes de abordagem intertextual, e os discute à luz de pressupostos hermenêuticos relacionados com uma visão elevada das Escrituras. Almeja-se sistematizar uma proposta de diretrizes de abordagem intertextual para a exegese bíblica e verificar a aplicabilidade da mesma por meio o estudo de três passagens: Apocalipse 20:7-21:8, Jeremias 32:1-33:26 e Mateus 27:1-10.
Religión y sociedad: las ideas judías y adventistas sobre mesianismo
Authors: Cortes Maicol Alejandro
Published: September 2024

Hay dos tendencias dominantes acerca de la era mesiánica en el judaísmo, restaurativa y utópica. Después de estudiar brevemente ambas tendencias y ver como ellas son entendidas por los sionistas religiosos, este estudio analiza las ideas acerca de la era mesiánica en los adventistas del séptimo día. Al parecer, la manera en que se entiende la era mesiánica tiene repercusiones en la forma en que se comprende la relación entre religión y sociedad. Aunque la visión de la era mesiánica de los adventistas tiene similitudes con la de los sionistas, ambos grupos tienen discrepancias.
"Why are you making people stop working?”: the wording of the shabat commandment and the cry of the slaves in the Exodus
Authors: Cardoso von Mengden Vinicius , Bento da Silva Ruben Marcelino
Published: September 2024

This work will analyze the wording of the fourth commandment of the Decalogue, suggesting the possibility of this text being a response to Pharaoh's question in his previous dialogue with Moses: why are you making the people stop their work? To this end, it will present bibliographical research, supporting a brief exegesis of two versions of the commandment, as presented in the books of Exodus and Deuteronomy, analyzing their historical and literary context. It will verify possible motivations for the author of Exodus to specifically mention Pharaoh's discomfort with the cessation of activities in his domain and how the wording of the fourth commandment opposes the current culture regarding religion and the socioeconomic system based on the production and exploitation of labor.
Sepultamento ou cremação: a forma de dispor dos mortos frente a questões culturais, sociais e religiosas
Authors: Dorneles Vanderlei
Published: September 2024

As civilizações sempre demonstraram zelo e reverência ao dispor dos mortos. Entre os orientais, a cremação tem sido a prática predominante. Nas culturas judaica e cristã, o sepultamento tem sido o mais comum, mas nas últimas décadas a cremação se tornou uma prática dominante em muitos países ocidentais. A popularização dos crematórios no Ocidente levanta a importante questão se a Bíblia oferece prescrição sobre cremar ou sepultar os mortos. Este artigo reflete sobre o sepultamento e a cremação, sua ocorrência na história, suas taxas atuais e o que a Bíblia tem a dizer sobre isso. Os relatos bíblicos sobre sepultamento, punição por fogo e cremação são abordados do ponto teológico, com a finalidade de compreender a natureza do relato se prescritivo ou não. O essencial na discussão sobre a questão é destacar a esperança bíblica da restauração de todas as coisas em Cristo, incluindo a ressurreição dos seres humanos para a vida imortal ou para o juízo.
PROPOSTA DE SINAIS-TERMO PARA PROMOÇÃO DA SAÚDE DA MULHER: GARANTIA PLENA DO DIREITO LINGUÍSTICO DA MULHER SURDA
Authors: Mendes Francisco Gildete S. Amorim
Published: September 2024

O presente estudo se fundamenta nas discussões levantadas por diversos pesquisadores sobre a acessibilidade da saúde da mulher. São apresentadas as dificuldades de compreensão nos serviços de saúde – tanto para os profissionais do ramo quanto para os pacientes surdos, onde são trazidos relatos de insatisfação de ambas as partes com relação à comunicação. Desta forma, a presente pesquisa tem como objetivo apresentar os trabalhos já desenvolvidos no escopo da acessibilidade em saúde da mulher, especialmente com vistas a produzir o Glossário Bilíngue (Libras-Português) de Saúde da Mulher. Para isso, optou-se por uma busca preliminar de estudos que compõem a revisão de literatura, reunindo as perspectivas de pesquisadores e estudiosos da área. Os resultados se apresentam inicialmente em forma de tabela com sinais em Libras, a partir de vídeos disponíveis gratuitamente nas plataformas digitais. Foram elaboradas cinco fichas terminológicas que indicam uma parte dos 73 sinais-termo que estão sendo desenvolvidos. A elaboração dos materiais demonstrou atender uma carência que ainda se observa quanto à comunicação médico-paciente – que deve estar pautada nos direitos preconizados pelas legislações. Além disso, este estudo buscou incentivar a produção de novos materiais e conteúdos sobre o assunto em tela.
“MULHER-SURDA-PROFESSORA”: PROTAGONISMO NA EDUCAÇÃO DE SURDOS NO RIO GRANDE DO SUL
Authors: Gomes Lara Ana Paula
Published: September 2024

Nunca como no contemporâneo o protagonismo da mulher na área da educação esteve em ascendência. Daí resulta olhar para a “mulher-surda-professora”2  presente em nossos tempos. A educação é um dos campos mais propícios para  facilitar o protagonismo. E a mulher surda, nele, sente-se como sujeito diferente e útil. Com este artigo tencionamos citar a presença das “mulheres-surdas-professoras” e, com isso, apresentar suas contribuições à Pedagogia Surda3. Percebe se a importância da presença dessas “mulheres-surdas-professoras” na transformação necessária que acontece visando os espaços da educação bilíngue.
Ferramentas de descoberta e entrega para implementação em bibliotecas
Authors: Pavão Caterina Groposo , Gabriel Junior Rene Faustino , Vanz Samile Andrea de Souza
Published: September 2024

Introdução: A oferta de uma interface única de busca em bibliotecas possibilita a recuperação da informação de forma eficiente e rápida, independentemente do software ou plataforma na qual a informação original se encontre. Objetivo: Este estudo tem como objetivo descrever e analisar os principais serviços de descoberta e entrega. Metodologia: Utiliza método bibliográfico para identificar requisitos para avaliação de software para serviço de descoberta e entrega. Procedeu-se à identificação e caracterização de 11 ferramentas de descoberta e entrega tanto comerciais como livres e abertas, e a análise dos três sistemas abertos (Blacklight, eXtensible Catalog/XC e VuFind) a partir de 17 critérios identificados na literatura. Resultados: O Blacklight é a ferramenta que apresenta menos características avançadas, mas parece suficientemente flexível para os utilizadores acrescentarem as funcionalidades necessárias. O VuFind é a ferramenta que atende a 15 dos 17 critérios analisados e foi testado em uma busca integrada de registros provenientes do DSpace e Dataverse, softwares mais utilizados no Brasil para repositórios de publicações e dados de pesquisa. Conclusão: O estudo conclui que o VuFind atende às demandas de integração de diversos sistemas utilizados em uma biblioteca no intuito de concentrar em um sistema de busca único todas as bases de dados mantidas pela instituição, tendo em vista que é uma ferramenta consolidada, desenvolvida em código aberto, disponibiliza documentação atualizada para sanar dúvidas, está em constante evolução, e possui uma comunidade de usuários ativa, inclusive no Brasil, com apoio do IBICT para solução de problemas.
Páginas Iniciais
Authors: Editorial Equipe
Published: September 2024

.
LICITAÇÃO PÚBLICA: ANÁLISE DOS PRINCÍPIOS DA RAZOABILIDADE, PROPORCIONALIDADE, AMPLA COMPETIÇÃO E SELEÇÃO DA PROPOSTA MAIS VANTAJOSA
Authors: Netto André L. Borges
Published: September 2024

.
FRAGILITÀ STORICA E TEORETICA DEL GIUSPOSITIVISMO
Authors: Lima Arlindo Pereira de
Published: September 2024

.
SISTEMA JURÍDICO ABERTO
Authors: Cavalcanti Lourival Silva
Published: September 2024

.
AÇÃO INIBITÓRIA: AÇÃO PREVENTIVA, DESTINADA A IMPEDIR A PRÁTICA, A REPETIÇÃO OU A CONTINUAÇÃO DO ILÍCITO, COM BASE NOS ARTIGOS 461, CPC E 84, CDC
Authors: Marinoni Luiz Guilherme
Published: September 2024

.
ÉTICA NA ADVOCACIA
Authors: D’Angelo Élcio Féliz
Published: September 2024

.
BIOMEDICINA E BIODIREITO: PERSPECTIVA SEMIOLÓGICO-CONSTITUCIONAL DA DIGNIDADE HUMANA E DO DIREITO À VIDA
Authors: Soto Érica Antônia Bianco de
Published: September 2024

.
ESTUDO SOBRE A POSIÇÃO HIERÁRQUICA DOS DECRETOS LEGISLATIVOS QUE INCORPORAM TRATADOS
Authors: Duarte Leonardo Avelino
Published: September 2024

.
INDIGENATO: A ESTRUTURA DE UM NOVO INSTITUTO DE DIREITO
Authors: Pauletti Maucir , Maranhão Ademar
Published: September 2024

.
40-70 Yaş Grubu Erkekler Arasında Prostat Kanseri Bilgi Düzeyi ve Benlik Saygısı Düzeyinin Değerlendirilmesi
Authors: Karagöz Bengisu , Ünsal Alaettin , Arslantaş Didem , Gölbaşı Koç Selva Dilan , Tepetaş Mine
Published: September 2024

Prostat kanseri, Global Kanser İstatistikleri 2018 Raporuna göre dünyada erkekler arasında en sık görülen 2. kanser türüdür. Erken teşhis ve etkili tedavi ile iyileşme sağlanabilen bu hastalığın erken tanısı için yapılan muayenelere katılımı etkileyen önemli faktörlerden biri bireylerin prostat kanseri hakkındaki bilgi düzeyleridir. Prostat kanseri hakkında bilgi düzeyi ile ilişkili olduğu düşünülen faktörler arasında benlik saygısı düzeyinin önemli bir yeri vardır. Çalışma, 01.09.2023– 31.10.2023 tarihleri arasında Eskişehir Osmangazi Üniversitesi Sağlık Uygulama ve Araştırma Hastanesi’ne başvuran 40-70 yaş grubu erkeklerde yapılan kesitsel tipte bir araştırmadır. Çalışma grubu 495 hastadan oluşmuştur. Prostat kanseri bilgi düzeyinin değerlendirilmesinde “Prostat Kanseri Taramaları Bilgi Ölçeği”, benlik saygısı düzeyinin belirlenmesinde ise “Rosenberg Benlik Saygısı Ölçeği (RBSÖ)” kullanılmıştır. Analizler için Mann-Whitney U testi, Kruskal Wallis testi ve Kolmogrov-Smirnov analizi kullanıldı. Anlamlılık değeri olarak p≤0.05 kabul edildi. Hastaların yaşları 40-70 arasında değişmekte olup, ortalama 53,9 ± 8,5 yıl idi. Prostat Kanseri Taramaları Bilgi Ölçeği’nden alınan puanlar 3- 11 arasında değişmekte olup, ortalama 6,6 ± 1,8 (ortanca: 7,0) puandır. Ölçekten alınan puanların 60 ve üzeri yaş grubunda olanlarda, daha önce prostat muayenesi yaptıranlarda, önceden prostat kanseri hakkında bilgi sahibi olanlarda, daha önce PSA testini duyanlarda, önceden prostat kanseri ile ilgili muayene olanlarda daha yüksek olduğu saptanmıştır. Prostat Kanseri Taramaları Bilgi Ölçeği’nden alınan puanlar ile RBSÖ’nden alınan puanlar arasında bir ilişki olmadığı saptanmıştır (r=0.073; p=0.106). Hastaların prostat kanseri hakkındaki bilgilerinin orta düzeyde olduğu söylenebilir. Prostat kanseri bilgi düzeylerinin arttırılması için bilgilendirme çalışmalarının yapılması faydalı olabilir.
The role of circular economy in supporting sustainable development goals (SDGs) in Indonesia from an Islamic economic perspective
Authors: Ni’mah Iffatun , Rokhim Abdul , Musari Khairunnisa
Published: September 2024

IntroductionHuman life is currently in a critical situation regarding environmental awareness. Discussions on sustainable development have become a key topic in building sustainable SDGs to achieve environmental preservation. Sustainable development is a crucial benchmark of environmental conservation.ObjectivesThis study aims to explain how the use of circular economy strategies can achieve sustainable development goals in line with the SDGs from an Islamic economic perspective.MethodThis study employed a qualitative literature review method. Secondary data sources, such as books, scientific journals, and previous articles, form the basis for analyzing various issues related to circular economy strategies and sustainable development.ResultsThe findings indicate that the circular economy plays an important role in supporting sustainable development goals in Indonesia, particularly in achieving SDG goal number 8, which aims for sustainable, inclusive economic growth and the creation of decent work for all. Additionally, the circular economy is closely related to achieving SDG goal number 12, which ensures sustainable consumption and production patterns. Islamic economics plays a crucial role in supporting the implementation of SDGs in Indonesia by involving various products and ecosystems, including Sharia-compliant financial products, halal food and beverages, Islamic entrepreneurs, and the circular economy related to resource utilization.ImplicationsThe results highlight the importance of the circular economy as a strategic approach for addressing environmental challenges and achieving long-term sustainability. The integration of Islamic economic principles offers a robust framework to promote ethical and responsible resource management.Originality/NoveltyThis study provides a unique perspective by combining the concepts of circular economy and Islamic economics to explore their combined impact on achieving sustainable development goals. This contributes to a broader understanding of how cultural and religious principles can enhance sustainability.
Eco-Consciousness and Eco-Semiotics in Amruta Patil’s Kari: An Exploration of Queer Ecology
Authors: Jensi Helan J  , Borah Rashmi
Published: September 2024

The field of ecology in literature distorted the notion of humans being the centre of all living ecosystems, striving for an “environment that is neither solipsistically anthropocentric nor blatantly anti-humanitarian” (Lauer, 2018, p.13). This led to the emergence of ecocriticism, which dealt with environmental issues through literature. “To put it succinctly, eco criticism is the study of the relationship between literature and the physical environment… [As it] takes an earth-centred approach to literary studies” (Glotfelty & Fromm, 1996, p.18). Meanwhile, disregarding the societal norms constructed on sex, gender, and identity emerged queer theory, suggesting the fluidity of the human body. Despite their inherent differences, environmental criticism and queer theory have the opportunity to combine to produce a new dimension called queer ecology. This analysis aims to establish a connection between eco-criticism and queer theory, shedding light on the concept of queer ecology through the analysis of the literary text Kari.
Kari, written by the first female graphic novelist, stands as a pioneering Indian lesbian graphic novel that effectively dismantles prevailing societal norms and challenges perspectives on genderqueer individuals. Further, the analysis narrows itself to an eco-conscious approach from a queer perspective, which claims to be the main argument of the article. In its graphical representation, this analysis also focuses on the meaning nature provides us through symbols defining eco-semiotics. The purpose of the study is to contribute to a greater understanding of environmental exploitation concerning the marginalisation experienced by the queer community. The eco-conscious attitude that is looked upon from a queer perspective serves to prove the mutual interdependence between eco-critical and queer sexual desires that are often negated, ignored, exploited and marginalised amidst the dominant ideological discourses.
Miniaturized-specimen creep testing: an alternative for evaluating the remaining life of Cr-Mo steel components
Authors: Cunha Furtado Heloisa , Martins dos Santos Fernanda Figueiredo , Araújo Leonardo Sales , Bueno Levi de Oliveira
Published: September 2024

Creep is the main degradation mechanism in steel and superalloy components operating at high temperatures in thermal and nuclear power generation units. Therefore, acquiring creep data during equipment operation is vital for a realistic calculation of the remaining useful life of these units. However, there are severe limitations to obtaining sufficient material for standard-size specimen fabrication and representative sample of the component. Therefore, replacing conventional specimens with small-size specimens, which can be fabricated from a limited amount of material, can facilitate the assessment of power plant components by creep tests without any structural damage. This study aims to compare creep-test results of Cr-Mo ferritic steel using conventional and small-size specimens to assess the effectiveness of using miniaturized specimens for analysis. The results of this study confirm the applicability of miniaturized-specimen creep testing for the reliable estimation of the materials’ remaining life. The results also emphasize the importance of carrying out creep test on miniaturized samples under vacuum, to avoid harmful effects due to the formation of the oxide layer.
Long-Term Effects of Nitrogen and Tillage on Yields and Nitrogen Use Efficiency in Irrigated Corn
Authors: Delgado Jorge A. , D'Adamo Robert E. , Villacis Alexis H. , Halvorson Ardell D. , Stewart Catherine E. , Floyd Bradley A. , Del Grosso Stephen J. , Manter Daniel K. , Alwang Jeffrey
Published: September 2024

By tonnage, corn (Zea mays L.) is the #1 crop produced globally, and recent research has suggested that no-till (NT) systems can lead to reduced yields of this important crop. Additionally, there is a lack of long-term data about the effects of tillage and N management on cropping systems. Corn is the most nitrogen (N)-fertilized crop in the USA, and N losses to the environment contribute to significant impacts on air and water quality. We conducted long-term studies on conventional tillage (CT), and conservation tillage systems such as strip tillage (ST) and NT, under different N rates. We found that immediately after conversion to NT, yields from NT were significantly lower than yields from CT (P<0.1), but after five years of NT, the NT yields were 1.5% higher than the CT yields (P<0.1). Initially, the NT yields were lower than the ST (P<0.01), but after seven years of NT, the NT yields were comparable to ST grain yields. Although the total aboveground N uptake with NT immediately after conversion to NT was lower than with CT and ST, these differences were not significant in the long run. The nitrogen use efficiency (NUE) with NT increased over time. The present work highlights the importance of long-term research for determining the cumulative impacts of best management practices such as NT. We found that NT becomes a more viable practice after five or seven years of implementation, demonstrating the high importance of long-term research.
DNA Gene's Basic Structure as a Nonperturbative Circuit Quantum Electrodynamics: Is RNA Polymerase II the Quantum Bus of Transcription?
Authors: RIERA LEAL ANNIE , RIERA AROCHE RAUL , ORTIZ GARCIA YVETH MARLENE , SANCHEZ MORENO ESLI CAMILA , ENRIQUEZ CERVANTES JOSE SAULO , MACHADO SULBARAN ANDREA CAROLINA
Published: September 2024

Previously, we described that Adenine, Thymine, Cytosine, and Guanine nucleobases were superconductors in a quantum superposition of phases on each side of the central Hydrogen bond acting as a Josephson Junction. Genomic DNA has two strands wrapped helically around one another, but during transcription, they are separated by the RNA polymerase II to form a molecular condensate called the transcription bubble. Successive steps involve the bubble translocation along the gene body. This work discusses how quantum information transfer and entanglement can be achieved by modeling DNA as a combination of
Federated Learning Based Futuristic Fault Diagnosis and Standardization in Rotating Machinery
Authors: K Vijyalakshmi , Rajakannu Amuthakkannan , KP Ramachandran , AV Srirajkavin
Published: September 2024

In the industrial sector, intelligent sensors in fault diagnosis are becoming more critical in recent technological improvements. The prediction accuracy can be enhanced in fault diagnosis using 3-dimensional, sequential, real-time, and image data. Sensors that capture the vibration, sound, and image data are more critical in predicting unbalancing, tool wear, crack, misalignment, etc, in the rotating machinery to increase productivity and to provide an effective maintenance management system. Due to the fast development of industry 4.0 techniques, monitoring of mechanical machinery is experiencing explosive growth and getting more attention in the area of fault diagnosis (FD). Machine learning and Deep learning methods give promising results and accuracy in predicting faults in rotating machinery on shop floors. The success of AI-based models is due to the availability of comprehensive labeled data. Federated Learning (FL) is the machine learning subfield aiming to train an algorithm with a heterogeneous dataset. Data transmission from local facilities to a central server in AI models creates data privacy and security issues. Heterogeneous data analysis is a complicated process in predicting the machine fault in the central server because of millions of data during real-time condition monitoring. Decentralized data handling and analysis is mandatory in condition monitoring because of heterogeneity in data processing, data privacy, and security advantages. The application of federated learning in fault diagnosis has been getting more attention in recent days, and this study is a review of FL applications that address fault diagnosis in rotating machinery in the first phase. A comparison between the types of FL approaches in FD and the use of aggregation algorithms and their applications will also be discussed in Phase 1. In phase 2, a novel methodology has been proposed using Federated learning to diagnose rotating machinery faults. The proposed method, FLOACOS, addresses how prediction challenges are solved using federated learning approaches by optimizing and standardizing the data at local facilities. This work will be helpful for future condition monitoring researchers and gives an overview of a novel method of the FL technique used in predicting faults and the progress made in the maintenance management of rotating machinery.
Risk–Return Anomalies: Evidence Based on the Co-Moment Augmented Fama–French Three-Factor Model in the Nigerian Stock Market
Authors: Ajayi Abiodun Samue , Arewa Ajibola , Omorojor Joy Ejighomegba , Falaye Adebanjo Joseph
Published: September 2024

In this study, we provided an empirical testability of the FF3FM against the co-moment-augmented FF3FM using the Newey–West GMM methods to account for potential endogeneity. The results showed that value risk is not significantly priced, and systematic skewness and systematic kurtosis play more important roles in explaining asset return than market and size factors. We discovered that there is much to gain in moving from the incumbent FF3FM to the co-moment-augmented FF3FM. By extending this study to Nigeria and using out-of-sample data that span across the recent COVID-19 period, the study has contributed to existing knowledge significantly. The study concludes that the co-moment-augmented FF3FM is superior to the incumbent FF3FM in pricing assets, and the anomalies associated with the return-size risk factor relationship are reduced by accounting for systematic skewness and systematic kurtosis in the FF3FM. Therefore, we recommend that investors should take a long position in size-hedged portfolios and hold systematic skewness and kurtosis as constant, and vice visa.
Biotechnological Tool for Metal(loids) Management with Multiple Approaches
Authors: Scotti Adalgisa , Castaño Gañan Ana Rosa , Silvani Vanesa Analia , Juarez Natalia Andrea , Coria Gabriela , Utge Perri Sofía , Colombo Roxana Paula , García Romera Inmaculada , Izaguirre-Mayoral María Luisa , Godeas Alicia Margarita , Ubaldini Stefano
Published: September 2024

Contaminated soils are a challenge for implementing biotechnology in bioremediation, recovery of Critical and Strategic Raw Materials (CRMs and SRMs), and food security. European Union (EU) Governments have established strict limits on As, Pb, Cd, and Hg in foods (Document 32023R0915), and requested the recovery of 34 CRMs within a circular economy (CE) (5th CRMs list). This study proposed a biotechnological tool for the decontamination of soil with heavy metal(loids) by arbuscular mycorrhizal (AM)-assisted phytoextraction and subsequent recovery of CRMs, or by phytostabilization to prevent their entry into the food chain. It consisted of placing Baccharis salicifolia plants, inoculated or non-inoculated with AM fungi, into Bioreactors (BRs) containing mining soil with Cd, Ni, and Cu, according to the argentinian Patent (AR090183B1). The bioextractive potential (BP) was also estimated at the highest Technological Readiness Level (TRL) using a Vegetable Depuration Module (VDM, TRL 6). Inoculated plants showed significantly higher aerial bioaccumulation coefficients (Cd: 68.62; P: 2.99; Ni: 2.51; Cu: 0.18) in BRs, and the BP values reached 1.16 g, 9.75 g, 2.40 g, and 213.1 g for Ni, Cd, Cu, and P, respectively. Finally, those CRMs and SRMs could be recovered from biomass through hydrometallurgy within a CE framework.
Coley`s Toxin to first Approved Therapeutic Vaccine - a Brief Historical Account in the Progression of Immunobiology Based Cancer Treatment
Authors: Devaraja K. , Singh Manisha , Sharan Krishna , Aggarwal Sadhna
Published: September 2024

Cancer immunobiology is one of the hot topics of discussion amongst researchers today, and immunotherapeutic modalities are among the selected few emerging approaches to cancer treatment that have exhibited a promising outlook. However, immunotherapy is not a new kid on the block; it has been around for centuries. The origin of cancer immunotherapy in modern medicine can be traced back to the initial reports of spontaneous regression of malignant tumors in some patients following an acute febrile infection, at the turn of the twentieth century. This review briefly revisits the historical accounts of immunotherapy, highlighting some of the significant developments in the field of cancer immunobiology, that have been instrumental in bringing back the immunotherapeutic approaches to the forefront of cancer research. Some of the topics covered are: Coley's toxin - the first immunotherapeutic; the genesis of the theory of immune surveillance; discovery of T-lymphocytes and dendritic cells and their roles; the role of tumor antigens; relevance of tumor microenvironment; anti-tumor (therapeutic) ability of Bacillus Calmette Guerin; Melacine - the first therapeutic vaccine engineered; theories of immunoediting and immunophenotyping of cancer; and Provenge – the first FDA approved therapeutic vaccine. In this review, head and neck cancer has been taken as the reference tumor, for narrating the progression of cancer immunobiology, particularly, for highlighting the advent of immunotherapuetic agents.
Aptamer-Guided Gene Therapy for Cancer Disease
Authors: Coppola Gabriele , Cennamo Fabiola , Ciccone Giuseppe , Ibba Maria Luigia , Di Vito Aldo , Esposito Carla Lucia , Catuogno Silvia
Published: September 2024

Gene therapy is a medical approach capable of correcting genetic and epigenetic alterations in pathological conditions, including cancer. Different strategies have been pursued for cancer gene therapy, aiming to restore the function of tumor suppressor genes or inhibit oncogenes. These comprise the use of CRISPR/Cas9 gene editing technology and therapeutic oligonucleotides, such as microRNAs, anti-microRNAs, small interfering RNAs, DNAzymes, and epigenetic modifiers. However, despite great potential, their broad clinical use is hindered due to the lack of safe and efficient systems for targeted delivery to cancer cells. To this purpose, aptamers could represent an ideal tool. They are short single-stranded oligonucleotides that bind receptors selectively present or overexpressed on cancer cell membranes, often undergoing cell-specific internalization. Thanks to this last feature, numerous internalizing aptamers have been investigated as targeting moiety to deliver therapeutic oligonucleotides, viral vectors, and nanoparticle-based systems in preclinical studies. Here, we summarize the state-of-the-art of aptamer applications in cancer gene therapy, providing key examples and discussing their advantages, limitations, and clinical perspectives.
Safety and Tolerability of a Shorter Agalsidase Beta Infusion Time in Patients with Classic or Later-onset Fabry Disease
Authors: Germain Dominique P , Porto Vasconcelos Alice , Tran Thi Phuong Liên , Bedreddine Najya , Turcan Mihaela , Trang Wenting , Barache Lynda
Published: September 2024

Background : The multisystem manifestations of Fabry disease can create major challenges in patient care. Although enzyme replacement therapy with recombinant agalsidase beta has demonstrated clinical benefits, the standard fortnightly, multihour infusion regimen imposes a substantial burden on patients. Methods : We assessed the safety and feasibility of shortening the agalsidase beta infusion time to 90 minutes in adult patients with classic or later-onset Fabry disease in the absence of premedication. A total of 39 consecutive adult patients (agalsidase-naive: n=6; significant comorbidities: n=15) with no recent infusion-associated reactions underwent a total of 85 agalsidase beta infusions in our tertiary reference center for lysosomal diseases. Each infusion was administered at a constant rate (between 0.78 and 1.17 mg/min, depending on the patient’s body weight). Results : No adverse events of any type (including discomfort and infusion-associated reactions) were reported during or after infusions. The patients’ vital signs remained stable, and patient satisfaction was high. Seven patients requested even shorter infusions (50 to 60 minutes) under strict medical supervision. Conclusions : Our results suggest that shortening the agalsidase beta infusion time to 90 minutes is safe and feasible in stably treated adult patients with Fabry disease and no recent infusion-associated reactions.
Enhancing Data Compression: Recent Innovations in LZ77 Algorithms
Authors: Hong Aaron , Boucher Christina
Published: September 2024

The burgeoning volume of genomic data, fueled by advances in sequencing technologies,
demands efficient data compression solutions. Traditional algorithms like Lempel-Ziv77 (LZ77) have
been foundational in offering lossless compression, yet they often fall short when applied to the
highly repetitive structures typical of genomic sequences. This review delves into the evolution of
LZ77 and its derivatives, exploring specialized algorithms such as prefix-free parsing, AVL grammars,
and LZ-based methods tailored for genomic data. Innovations in this field have led to enhanced
compression ratios and processing efficiencies by leveraging the intrinsic redundancy within genomic
datasets. We critically examine a spectrum of LZ77-based algorithms, including newer adaptations
for external and semi-external memory settings, and contrast their efficacy in managing large-scale
genomic data. Additionally, we discuss the potential of these algorithms to facilitate the construction
of data structures such as compressed suffix trees, crucial for genomic analyses. This paper aims to
provide a comprehensive guide on the current landscape and future directions of data compression
technologies, equipping researchers and practitioners with insights to tackle the escalating data
challenges in genomics and beyond.
Deficiency of Inducible Costimulator (ICOS) during Chronic Infection with Toxoplasma gondii Upregulates CD28-Dependent Cytotoxicity of CD8+ T Cells and Their Effector Function against Tissue Cysts of the Parasite
Authors: Mani Rajesh , Balu Kanal , Suzuki Yasuhiro
Published: September 2024

We recently identified that cerebral mRNA expression for inducible costimulator (ICOS) and its ligans, ICOSL, both significantly increases during elimination of Toxoplasma gondii cysts from the brains of infected mice by perforin-mediated cytotoxic activity of CD8+ T cells. In the present study, we examined the role of ICOS in activating the effector activity of CD8+ T cells in response to the cysts in infected mice. Following adoptive transfer of splenic CD8+ T cells from chronically infected ICOS-deficient (ICOS-/-) and wild-type (WT) mice to infected SCID mice, fewer CD8+ T cells were detected in the brains of the recipients of ICOS-/- than WT CD8+ T cells. However, such lower numbers of ICOS-/- CD8+ T cells, which migrated into the brains of the recipients, eliminated T. gondii cysts more efficiently than WT CD8+ T cells did. Consistently, the ICOS-/- CD8+ T cells secreted greater amounts of granzyme B in response to T. gondii antigens in vitro than did WT CD8+T cells. We identified that ICOS-/- CD8+ T cells express significantly greater levels of CD28 on their surface than WT CD8+ T cells, and relative expression levels of CD28 mRNA in ratios to CD8b mRNA levels in the brains of the recipients of those CD8+ T cells strongly correlated with their relative expression levels of mRNA for T-bet transcription factor and perforin. Furthermore, blocking of CD28 signaling by a combination of anti-CD80 and anti-CD86 antibodies abolished the increased cytotoxic activity of the ICOS-/- CD8+ T cells in vitro. The present study uncovered notable compensatory interactions between ICOS and CD28 to secure the cytotoxic effector activity of CD8+ T cells against a microbial infection in a murine model of chronic infection with T. gondii.
The Impact of Aerobic Exercise on a Novice Athlete with Crohn's Disease: A Case Study from Greece
Authors: Paraskevopoulos Eleftherios
Published: September 2024

This case study explores the impact of moderate-intensity exercise on a 35-year-old male novice runner diagnosed with Crohn's Disease (CD). Initially, his symptoms were managed with probiotics and rifaximin, but he experienced a resurgence after a COVID-19 infection, leading to treatment with budesonide. Despite initial hesitation, the patient resumed moderate-intensity running (60-80% VO2 max) after achieving remission. His bowel function, energy levels, and overall well-being improved significantly with exercise. This case suggests that structured physical activity can be beneficial for managing CD and maintaining remission, even amidst fluctuating symptoms and inflammatory markers. It supports the idea that moderate-intensity exercise, when carefully managed, does not inherently worsen the condition and can enhance quality of life. These findings advocate for personalized exercise programs as part of CD management, though further research is needed to establish comprehensive guidelines and evaluate the long-term effects of different exercise intensities on Crohn's Disease.
An Open Frame Loading Stage for High-Resolution Microtomography
Authors: Plappert David , Ganzenmüller Georg C.
Published: September 2024

High-resolution in-situ CT measurements in the (sub-)$\upmu$m range are typically only feasible in synchrotron facilities, as the use of a conventional loading stage in laboratory CTs with a cone beam source does not permit a corresponding geometric magnification. This publication presents a CT system with a novel concept that allows spatial resolutions down to 0.5 $\upmu$m on the one hand, and on the other hand is able to apply loads up to 5 kN in compression and tension direction to the sample during the measurement. This leads to a challenging design of the system with regard to the required precision of the mechanical setup, if measurements close to the theoretically possible magnification can be carried out successfully. The components utilized are presented, along with the requisite considerations and methodologies. It can be demonstrated that the intended specifications with regard to precision and quality are met. Finally, a complex measurement problem in materials science is presented as an illustrative example that demonstrates the potential of the system described.
Uric Acid Transporter Gene SLC22A12 is a Chimera of Multiple Ancestral Genes
Authors: Misawa Kazuharu
Published: September 2024

The URAT1 protein is crucial in absorbing urate in human kidneys. A recent study showed that that Xenopus tropicalis (tropical clawed frog) appears to lack renal urate transporters. This finding raises questions regarding the origin of the SLC22A12 gene which encodes URAT1. The origin of the SLC22A12 gene is being discussed through two hypotheses. The first hypothesis, termed the URAT1-early hypothesis, posits that SLC22A12 was present in the common ancestor of tetrapods and was subsequently lost in amphibian lineages. The second hypothesis, the URAT1-late hypothesis, suggests that the SLC22A12 gene arose uniquely within the lineage leading to mammals. The purpose of this study is to determine which hypothesis is more reasonable for describing the origin of SLC22A12. This study suggests that the SLC22A12 gene the SLC22A12 gene was generated via a fusion of the SLC22A6 and SLC22A20 genes. Thus, the URAT1-late hypothesis is more likely to explain the origin of the SLC22A12 gene. X. tropicalis lacks the SLC22A12 gene, probably because the emergence of SLC22A12 occurred after the divergence of the ancestors of mammals and amphibians. The evolutionary studies of the SLC22A12 will offer valuable insights on how to choose model organisms for studies of the uric acid transporter URAT1.
Impact of Severe Obesity on Outcomes in Single-Level Anterior Cervical Discectomy and Fusion (ACDF): A Large-Scale Comparative Study
Authors: Maman David , Bar Ofek , Steinfeld Yaniv , Sliman Ali , Shpigelman Arsen , Ben-Zvi Lior , Berkovich Yaron
Published: September 2024

Background: Anterior cervical discectomy and fusion (ACDF) is a common procedure for cervical radiculopathy and myelopathy. Severe obesity (BMI ≥40 or BMI ≥35 with comorbidities) is associ-ated with increased perioperative risks. This study examines the impact of severe obesity on out-comes in patients undergoing single-level ACDF.
Methods :Data from the Nationwide Inpatient Sample (2016-2019) were analyzed, including 85,585 patients who underwent single-level ACDF. Patients were classified as severely obese (n = 4,935) or non-obese (n = 80,650). Outcomes such as length of stay, complications, and in-hospital mortali-ty were compared using SPSS and MATLAB, with a significance level of p < 0.05.
Results: Severely obese patients were younger (54 vs. 55.7 years, p < 0.001) and had more comor-bidities like type 2 diabetes (38% vs. 17.8%, p < 0.001) and obstructive sleep apnea (31.1% vs. 9.5%, p < 0.001). They experienced longer hospital stays (1.92 vs. 1.65 days, p < 0.001) but similar in-hospital mortality (0.1%, p = 0.506). Severe obesity was linked to higher odds of complications, the risk of developing dehiscence was 8.2 times higher in severely obese patients. Respiratory failure had an odds ratio of 6.5, while myocardial infarction showed an odds ratio of 5.5. Horner syn-drome was 4.7 times more likely to occur, and pulmonary edema had an odds ratio of 4.5. Dural tear risk was also significantly elevated, with an odds ratio of 4.1.The risk of developing acute kid-ney injury were 2.6 times higher, while the risk of pulmonary embolism was 2.5 times higher. Dysphonia was also more common in severely obese patients, with an odds ratio of 2.2.
Conclusion:
Severe obesity is associated with higher complication rates and longer hospital stays following ACDF. Tailored perioperative management is essential to mitigate risks and improve outcomes in this high-risk population.