bluuebunny/crossref_metadata_2025 huggingface dataset:
The Impact of a Childhood Cancer Diagnosis on the Children and Siblings’ School Attendance, Performance, and Activities: A Qualitative Descriptive Study
Authors: Tsimicalis Argerie , Genest Laurence , Stevens Bonnie , Ungar Wendy J. , Barr Ronald
Published: December 2017

Families of children with cancer are confronted with unexpected out-of-pocket expenses and productivity costs associated with the diagnosis. One productivity cost that falls on children is the impact of cancer on children’s school attendance, performance, and activities (eg, play, friendships, and socialization). Nested within the Childhood Cancer Cost Study, this qualitative descriptive study used convenience sampling to recruit and interview parents of children newly diagnosed with cancer. Content analysis techniques were used to inductively descriptive the semistructured interview data. Sixty-six parents of 65 children with cancer and of 73 siblings participated. The most commonly reported productivity loss in children with cancer was school absenteeism mainly due to cancer treatment. Children fell behind their classmates academically and lost important social time with peers. A few siblings also fell behind their peers primarily due to limited parental attention. Parents adopted various strategies to lessen the impact of the diagnosis on their children’s school attendance, performance, and activities. Providing parents with additional resources and support may optimize their children’s academic and social reintegration into school.
The ubiquitous baseball cap: Identity, style, and comfort in late modern times
Authors: Kelly William W.
Published: December 2017

The baseball cap completes the T-shirt, blue jeans, and sneakers as the common kit of late modern life, the recent decades when consumption, as acquisition, display, and deployment, has become preeminent in asserting self-identity and negotiating social placement. This essay traces the codification and commercialization of the baseball cap within that sport and its adoption by other sports and spectators. It argues that for fans the cap within the stadium is more than passive allegiance but rather a material performative. The essay then follows the cap into everyday life, where it has become the dominant headwear because its material qualities can enable affiliation, fashion, and comfort. Although the baseball cap is ubiquitous at the present moment, its frequency is variable, as evidenced by timed counts in public spaces in the three baseball nations of United States, Japan, and Cuba. The article concludes by suggesting some factors that may explain the cap’s transgressive motility across sport, work and everyday life, across fashion codes, and across gender and class divides.
Parental Migration, Children’s Safety and Psychological Adjustment in Rural China: A Meta-Analysis
Authors: Chen Mengtong , Sun Xiaoyue , Chen Qiqi , Chan Ko Ling
Published: December 2017

Studies concerning left-behind children in rural China have shown that parental absence due to migration is associated with greater risk of child victimization and accidental injuries, and a range of psychosocial problems. The authors conducted this meta-analysis to determine the extent to which left-behind children are affected by parental migration, as compared to children in nonmigrant rural families. A comprehensive literature search was conducted, and 90 studies published before 2017 were included in the data synthesis and analysis. The results revealed that compared to non-left-behind children, rural left-behind children are generally more disadvantaged in regard to child safety ( d = 0.27) and psychological adjustment ( d = 0.25). The effect sizes, though interpreted as small, revealed that children in rural China are significantly affected by parental migration. Children’s educational stage was a significant variable that moderated the effect sizes of child safety and psychological adjustment. The findings of the meta-analysis indicated that mother-only migration may have the most harmful effect on children. In terms of implications for interventions, the results suggest more attention should be given to rural left-behind children and to “mother-absent children” in particular. Future research is warranted to explore the association between left-behind children’s psychological adjustment and their exposure to injury and victimization.
Researcher Safety? Ethnography in the Interdisciplinary World of Audit Cultures
Authors: Morgan Jennie , Pink Sarah
Published: December 2017

Anthropologists intermittently reflect on the danger and risk that ethnography can involve. Here, we advance this question in a contemporary research environment where the regulatory logics of occupational safety and health (OSH) encroach increasingly on anthropological practice through institutional research governance. We draw on our research into workplace OSH in the construction, health care, and logistics sectors—a research field dominated by behavioral theories that support the preventative logics of OSH regulation. Taking an autoethnographic approach, we explore how researching in potentially dangerous environments requires ethnographers to learn how to be safe through others’ situated safety logics and through those of researcher safety. It is, we argue, through these engagements with the improvisatory ways that workers generally, and researchers specifically, engage with safety, that another set of inconsistencies between OSH preventative logics and our anthropological understanding of how ethnographic knowing emerges become visible.
Prism Adaptation in Rehabilitation? No Additional Effects of Prism Adaptation on Neglect Recovery in the Subacute Phase Poststroke: A Randomized Controlled Trial
Authors: Ten Brink Antonia F. , Visser-Meily Johanna M. A. , Schut Martijn J. , Kouwenhoven Mirjam , Eijsackers Anja L. H. , Nijboer Tanja C. W.
Published: December 2017

Background. Patients with neglect ignore or respond slower to contralesional stimuli. Neglect negatively influences independence in activities of daily living (ADL). Prism adaptation (PA) is one of the most frequently studied treatments, yet there is little evidence regarding positive effects on neglect behavior in ADL. Objective. To assess whether PA in the subacute phase ameliorates neglect in situations of varying complexity. Methods. A total of 70 neglect patients admitted for inpatient stroke rehabilitation received either PA or sham adaptation (SA) for 2 weeks, with full access to standard treatment. There were 7 time-dependent measurements (baseline and 1-4, 6, and 14 weeks after start of treatment). The primary outcome was change of neglect as observed during basic ADL with the Catherine Bergego Scale (CBS). Secondary outcomes were changes in performance on a dynamic multitask (ie, the Mobility Assessment Course [MAC]) and a static paper-and-pencil task (ie, a shape cancellation task [SC]). Results. In all, 34 patients received PA and 35 SA. There were significant time-dependent improvements in performance as measured with the CBS, MAC, and SC (all F > 15.57; P < .001). There was no significant difference in magnitude of improvement between groups on the CBS, MAC, and SC (all F < 2.54; P > .113]. Conclusions. No beneficial effects of PA over SA in the subacute phase poststroke were observed, which was comparable for situations of varying complexity. Heterogeneity of the syndrome, time post–stroke onset, and the content of treatment as usual are discussed. Basic knowledge on subtypes and recovery patterns would aid the development of tailored treatment.
“Venimos Para Que se Oiga la Voz”: Activating Community Cultural Wealth as Parental Educational Leadership
Authors: Fernández Erica , Paredes Scribner Samantha M.
Published: December 2017

This article expands a more inclusive parental engagement framework by broadening notions of educational leadership using an example of organizing actions of Latina parent leaders amid a hostile anti-immigrant climate within an urban elementary school. Researchers draw on Yosso’s community cultural wealth framework to analyze how a Latinx parent group and parent leaders activated and nurtured community cultural wealth. The findings describe the ways in which the Latinx parent group fostered community cultural wealth and, in doing so, cultivated parental educational leadership. The authors discuss how the Latinx parent leaders then negotiated tensions that emerged between the Latinx parent group and school officials when a new parent organization was established at the school. We use this study to both disrupt traditional notions of educational leadership and discuss the implications it has for principal preparation programs.
Precision medicine: does ethnicity information complement genotype-based prescribing decisions?
Authors: Shah Rashmi R. , Gaedigk Andrea
Published: December 2017

Inter-ethnic differences in drug response are all too well known. These are underpinned by a number of factors, including pharmacogenetic differences across various ethnic populations. Precision medicine relies on genotype-based prescribing decisions with the aim of maximizing efficacy and mitigating the risks. When there is no access to genotyping tests, ethnicity is frequently regarded as a proxy of the patient’s probable genotype on the basis of overall population-based frequency of genetic variations in the ethnic group the patient belongs to, with some variations being ethnicity-specific. However, ever-increasing transcontinental migration of populations and the resulting admixing of populations have undermined the utility of self-identified ethnicity in predicting the genetic ancestry, and therefore the genotype, of the patient. An example of the relevance of genetic ancestry of a patient is the inadequate performance of European-derived pharmacogenetic dosing algorithms of warfarin in African Americans, Brazilians and Caribbean Hispanics. Consequently, genotyping a patient potentially requires testing for all known clinically actionable variants that the patient may harbour, and new variants that are likely to be identified using state-of the art next-generation sequencing-based methods. Furthermore, self-identified ethnicity is associated with a number of ethnicity-related attributes and non-genetic factors that potentially influence the risk of phenoconversion (genotype–phenotype discordance), which may adversely impact the success of genotype-based prescribing decisions. Therefore, while genotype-based prescribing decisions are important in implementing precision medicine, ethnicity should not be disregarded.
Investigation of curcumin-mediated signalling pathways in head and neck squamous cell carcinoma
Authors: Nanjappa Vishalakshi , Sathe Gajanan J. , Jain Ankit P. , Rajagopalan Pavithra , Raja Remya , Subbannayya Tejaswini , Patil Arun H. , Kumar Prashant , Prasad T. S. Keshava , Mathur Premendu Prakash , Sidransky David , Gowda Harsha , Chatterjee Aditi
Published: December 2017

Objectives:

Curcumin has been shown to exhibit anti-neoplastic effects. However, due to its poor bioavailability, the use of curcumin as an anti-cancer drug is limited. Thus, it is necessary to identify molecules as an alternative to curcumin that could serve as anti-cancer targets. In this study, we attempted to understand the underlying curcumin-mediated signalling pathways contributing to anti-neoplastic effects of curcumin.

Methods:

We carried out mass spectrometry-based phosphoproteomic analysis of head and neck cancer cell line, CAL 27, treated with and without curcumin to identify curcumin-mediated signalling pathways. Serine/threonine kinases were enriched using titanium dioxide.

Results:

This resulted in the identification of 5921 phosphopeptides corresponding to 1878 proteins. Of these, 275 and 183 phosphopeptides corresponding to 335 and 242 proteins (≥2.0-fold) were found to be hyper- and hypo-phosphorylated, respectively, in response to curcumin treatment. Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2), a serine/threonine kinase, and its downstream target protein kinase AMP-activated non-catalytic subunit beta 1 (PRKAB1) were found to be hypo-phosphorylated when treated with curcumin. Further, silencing or inhibiting CaMKK2 resulted in decreased invasion and colony forming ability of not only CAL 27 cells but also other head and neck squamous cell carcinoma (HNSCC) cell lines. Further, Western blot analysis showed that curcumin-mediated signalling is corroborated by CaMKK2.

Conclusions:

Taken together, our results suggest that CaMKK2 could be a novel therapeutic target in HNSCC and can serve as an alternative to curcumin.
A Radiographic Healing Classification for Osteochondritis Dissecans of the Knee Provides Good Interobserver Reliability
Authors: Ramski David E. , Ganley Theodore J. , Carey James L.
Published: December 2017

Background:

Recent studies have examined radiographic factors associated with healing of osteochondritis dissecans (OCD) lesions of the knee. However, there is still no gold standard in determining the healing status of an OCD lesion.

Purpose:

We examined temporally associated patterns of healing to (1) evaluate the practicality of a classification system and (2) elucidate any associations between healing pattern and patient age, sex, lesion location, treatment type, and physeal patency.

Study Design:

Cohort study (diagnosis); Level of evidence, 3.

Methods:

We retrospectively screened 489 patients from 2006 to 2010 for a total of 41 consecutive knee OCD lesions that met inclusion criteria, including at least 3 consecutive radiographic series (mean patient age, 12.8 years; range, 7.8-17.1 years; mean follow-up, 75.1 weeks). Radiographs were arranged in sequential order for ratings by 2 orthopaedic sports medicine specialists. Healing patterns were rated as boundary resolution, increasing radiodensity of progeny fragment, combined, or not applicable. Repeat ratings were conducted 3 weeks later.

Results:

Patients were most commonly adolescent males aged 13 to 17 years, with a medial femoral condyle lesion that was treated operatively. Interobserver reliability of the healing classification was good (intraclass correlation coefficient, 0.67; 95% CI, 0.55-0.79). Boundary and radiodensity healing was observed for all ages, sexes, lesion locations, treatment types, and physeal patency states.

Conclusion:

This study evaluated a valuable radiographic paradigm—boundary resolution, increasing radiodensity of progeny fragment, or combined—for assessment of OCD lesion healing. The proposed system of healing classification demonstrated good inter- and intraobserver reliability. Healing patterns were not significantly associated with any particular age, sex, lesion location, treatment type, or physeal patency status. The development of a classification system for knee OCD may eventually improve clinical assessment and management of OCD lesions.
Surfactant protein D is a causal risk factor for COPD: results of Mendelian randomisation
Authors: Obeidat Ma'en , Li Xuan , Burgess Stephen , Zhou Guohai , Fishbane Nick , Hansel Nadia N. , Bossé Yohan , Joubert Philippe , Hao Ke , Nickle David C. , van den Berge Maarten , Timens Wim , Cho Michael H. , Hobbs Brian D. , de Jong Kim , Boezen Marike , Hung Rayjean J. , Rafaels Nicholas , Mathias Rasika , Ruczinski Ingo , Beaty Terri H. , Barnes Kathleen C. , Paré Peter D. , Sin Don D.
Published: December 2017

Surfactant protein D (SP-D) is produced primarily in the lung and is involved in regulating pulmonary surfactants, lipid homeostasis and innate immunity. Circulating SP-D levels in blood are associated with chronic obstructive pulmonary disease (COPD), although causality remains elusive.

In 4061 subjects with COPD, we identified genetic variants associated with serum SP-D levels. We then determined whether these variants affected lung tissue gene expression in 1037 individuals. A Mendelian randomisation framework was then applied, whereby serum SP-D-associated variants were tested for association with COPD risk in 11 157 cases and 36 699 controls and with 11 years decline of lung function in the 4061 individuals.

Three regions on chromosomes 6 (human leukocyte antigen region), 10 (SFTPDgene) and 16 (ATP2C2gene) were associated with serum SP-D levels at genome-wide significance. In Mendelian randomisation analyses, variants associated with increased serum SP-D levels decreased the risk of COPD (estimate −0.19, p=6.46×10−03) and slowed the lung function decline (estimate=0.0038, p=7.68×10−3).

Leveraging genetic variation effect on protein, lung gene expression and disease phenotypes provided novel insights into SP-D biology and established a causal link between increased SP-D levels and protection against COPD risk and progression. SP-D represents a very promising biomarker and therapeutic target for COPD.
Decreased Parasympathetic Activity of Heart Rate Variability During Anticipation of Night Duty in Anesthesiology Residents
Authors: Wang Man-Ling , Lin Pei-Lin , Huang Chi-Hsiang , Huang Hui-Hsun
Published: December 2017

BACKGROUND:

In residency programs, it is well known that autonomic regulation is influenced by night duty due to workload stress and sleep deprivation. A less investigated question is the impact on the autonomic nervous system of residents before or when anticipating a night duty shift. In this study, heart rate variability (HRV) was evaluated as a measure of autonomic nervous system regulation.

METHODS:

Eight residents in the Department of Anesthesiology were recruited, and 5 minutes of electrocardiography were recorded under 3 different conditions: (1) the morning of a regular work day (baseline); (2) the morning before a night duty shift (anticipating the night duty); and (3) the morning after a night duty shift. HRV parameters in the time and frequency domains were calculated. Repeated measures analysis of variance was performed to compare the HRV parameters among the 3 conditions.

RESULTS:

There was a significant decrease of parasympathetic-related HRV measurements (high-frequency power and root mean square of the standard deviation of R–R intervals) in the morning before night duty compared with the regular work day. The mean difference of high-frequency power between the 2 groups was 80.2 ms2 (95% confidence interval, 14.5–146) and that of root mean square of the standard deviation of R–R intervals was 26 milliseconds (95% confidence interval, 7.2–44.8), with P = .016 and .007, respectively. These results suggest that the decrease of parasympathetic activity is associated with stress related to the condition of anticipating the night duty work. On the other hand, the HRV parameters in the morning after duty were not different from the regular workday.

CONCLUSIONS:

The stress of anticipating the night duty work may affect regulation of the autonomic nervous system, mainly manifested as a decrease in parasympathetic activity. The effect of this change on the health of medical personnel deserves our concern.
Changing Default Ventilator Settings on Anesthesia Machines Improves Adherence to Lung-Protective Ventilation Measures
Authors: Chiao Sunny S. , Colquhoun Douglas A. , Naik Bhiken I. , Ma Jennie Z. , Nemergut Edward C. , Durieux Marcel E. , Blank Randal S. , Forkin Katherine T.
Published: December 2017

Perioperative lung-protective ventilation (LPV) can reduce perioperative pulmonary morbidity. We hypothesized that modifying default anesthesia machine ventilator settings would increase the use of intraoperative LPV. Default tidal volume settings on our anesthesia machines were decreased from 600 to 400 mL, and default positive end-expiratory pressure was increased from 0 to 5 cm H2O. This modification increased mean positive end-expiratory pressure from 3.1 to 5.0 cm H2O and decreased mean tidal volume from 8.2 to 6.7 mL/kg predicted body weight. Notably, increased adherence to LPV from 1.6% to 23.0% occurred quickly with the rate of increase more than doubling from 1.8% to 3.9% per year.
Tailored Holder for Continuous Echocardiographic Monitoring
Authors: Song Haibo , Tsai Shen Kou , Liu Jin
Published: December 2017

Hemodynamic monitoring is essential for prompt and effective interventions in intensive care unit patients. We developed a custom-made transthoracic echocardiography transducer holder consisting of transducer holder and skin patch attachment. This holder allowed continuous transthoracic echocardiography monitoring in 5 adult patients with circulatory failure due to shock, and 6 pediatric patients after successful percutaneous closure of a ventricular septal defect. One case of an unexpected hemopericardium was promptly diagnosed and pericardiocentesis was performed, and 1 patient required extracorporeal membrane oxygenation support.
Reduced Left Ventricular Global Longitudinal Strain Predicts Prolonged Hospitalization: A Cohort Analysis of Patients Having Aortic Valve Replacement Surgery
Authors: Sonny Abraham , Alfirevic Andrej , Sale Shiva , Zimmerman Nicole M. , You Jing , Gillinov A. Marc , Sessler Daniel I. , Duncan Andra E.
Published: December 2017

BACKGROUND:

Left ventricular ejection fraction (LVEF) is often preserved in patients with aortic stenosis and thus cannot distinguish between normal myocardial contractile function and subclinical dysfunction. Global longitudinal strain and strain rate (SR), which measure myocardial deformation, are robust indicators of myocardial function and can detect subtle myocardial dysfunction that is not apparent with conventional echocardiographic measures. Strain and SR may better predict postoperative outcomes than LVEF. The primary aim of our investigation was to assess the association between global longitudinal strain and serious postoperative outcomes in patients with aortic stenosis having aortic valve replacement. Secondarily, we also assessed the associations between global longitudinal SR and LVEF and the outcomes.

METHODS:

In this post hoc analysis of data from a randomized clinical trial (NCT01187329), we examined the association between measures of myocardial function and the following outcomes: (1) need for postoperative inotropic/vasopressor support; (2) prolonged hospitalization (>7 days); and (3) postoperative atrial fibrillation. Standardized transesophageal echocardiographic examinations were performed after anesthetic induction. Myocardial deformation was measured using speckle-tracking echocardiography. Multivariable logistic regression was used to assess associations between measures of myocardial function and outcomes, adjusted for potential confounding factors. The predictive ability of global longitudinal strain, SR, and LVEF was assessed as area under receiver operating characteristics curves (AUCs).

RESULTS:

Of 100 patients enrolled in the clinical trial, 86 patients with aortic stenosis had acceptable images for global longitudinal strain analysis. Primarily, worse intraoperative global longitudinal strain was associated with prolonged hospitalization (odds ratio [98.3% confidence interval], 1.22 [1.01–1.47] per 1% decrease [absolute value] in strain; P = .012), but not with other outcomes. Secondarily, worse global longitudinal SR was associated with prolonged hospitalization (odds ratio [99.7% confidence interval], 1.68 [1.01–2.79] per 0.1 second−
1 decrease [absolute value] in SR; P = .003), but not other outcomes. LVEF was not associated with any outcomes. Global longitudinal SR was the best predictor for prolonged hospitalization (AUC, 0.72), followed by global longitudinal strain (AUC, 0.67) and LVEF (AUC, 0.62).

CONCLUSIONS:

Global longitudinal strain and SR are useful predictors of prolonged hospitalization in patients with aortic stenosis having an aortic valve replacement.
NudE regulates dynein at kinetochores but is dispensable for other dynein functions in the C. elegans early embryo
Authors: Simões Patrícia A. , Celestino Ricardo , Carvalho Ana X. , Gassmann Reto
Published: December 2017

In mitosis, the molecular motor dynein is recruited to kinetochores by the Rod–Zw10–Zwilch complex (RZZ) and Spindly to control spindle assembly checkpoint (SAC) signaling and microtubule attachment. How the ubiquitous dynein co-factors Lis1 and NudE contribute to these functions remains poorly understood. Here, we show that the C. elegans NudE homolog NUD-2 is dispensable for dynein- and LIS-1-dependent mitotic spindle assembly in the zygote. This facilitates functional characterization of kinetochore-localized NUD-2, which is recruited by the CENP-F-like proteins HCP-1 and HCP-2 independently of RZZ–Spindly and dynein–LIS-1. Kinetochore dynein levels are reduced in Δnud-2 embryos, and, as occurs upon RZZ inhibition, loss of NUD-2 delays the formation of load-bearing kinetochore–microtubule attachments and causes chromatin bridges in anaphase. Survival of Δnud-2 embryos requires a functional SAC, and kinetochores without NUD-2 recruit an excess of SAC proteins. Consistent with this, SAC signaling in early Δnud-2 embryos extends mitotic duration and prevents high rates of chromosome mis-segregation. Our results reveal that both NUD-2 and RZZ–Spindly are essential for dynein function at kinetochores, and that the gain in SAC strength during early embryonic development is relevant under conditions that mildly perturb mitosis.
Swim and fly. Escape strategy in neustonic and planktonic copepods
Authors: Svetlichny Leonid , Larsen Poul S. , Kiørboe Thomas
Published: December 2017

Copepods may respond to predators by powerful escape jumps that in some surface dwelling forms may propel the copepod out of the water. We studied the kinematics and energetics of submerged and out-of-water jumps of two neustonic pontellid Anomalocera patersoni and Pontella mediterranea and one pelagic calanoid copepod Calanus helgolandicus (euxinus). We show that jumping out of the water does not happen just by inertia gained during the copepod's acceleration underwater, but also requires the force generated by the thoracic limbs when breaking through the water's surface to overcome surface tension, drag, and gravity. Such timing appears necessary for success. At the moment of breaking the water interface the instantaneous velocity of the two pontellids reaches 125 cm s−1, while their maximum underwater speed (115 cm s−1) is close to that of similarly sized C. helgolandicus (106 cm s−1). The average specific powers produced by the two pontellids during out-of-water jumps (1700-3300 W kg−1 muscle mass) is close to that during submerged jumps (900-1600 kg−1 muscle mass) and, in turn, similar to that produced during submerged jumps of C. helgolandicus (1300 W kg−1 muscle mass).The pontellids may shake off water adhering to their body by repeated strokes of the limbs during flight, which imparts them a slight acceleration in the air. Our observations suggest that out-of-water jumps of pontellids are not dependent on any exceptional ability to perform this behavior but have the same energetic cost and are based on the same kinematic patterns and contractive capabilities of muscles as those of copepods swimming submerged.
Από τον Έλληνα ως πρόσωπο στο πρόσωπο ως Έλληνα
Authors: Αγγελόπουλος Γεώργιος
Published: December 2017

Δεν διατίθεται περίληψη στα ελληνικά
ΘΕΟΦΙΛΟΣ ΒΕΪΚΟΣ, Ο κόσμος σε διασπορά. Έθνη καί Οικουμένη, Ελληνικά Γράμματα, Αθήνα 1995, 68 σελ.
Authors: Ρήγος Άλκης
Published: December 2017

[Δεν διατίθεται περίληψη / no abstract available]
Η κρυφή γοητεία της ιδεολογίας. Αντι-θεωρητισμός και εκλεκτικισμός στη μελέτη του εργατικού κινήματος
Authors: Σεφεριάδης Σεραφείμ
Published: December 2017

Δεν διατίθεται περίληψη στα ελληνικά
Teaching resources of art cinema in the context of teaching the Humanities in the contemporary universities
Authors: Щеглова Людмила , Shcheglova Lyudmila , Саенко Наталья , Saenko Natalya
Published: December 2017

The article settles the task of the research and testing of new effective forms of development of humanitarian knowledge. Such cinema technologies are the film seminar, interactive lectures, video seminars, prepared discus- sion on the film, etc. Authors analyze humanitarian and moral sphere of man and society through analysis of cultural and moral determinants, reflected in the works of cinema. The relevance of the article is determined with the obvious crisis of the institutional forms which still develop the fundamental cultural and philosophical education, and which leads to the obsolescence of the translation forms of generalized knowledge. The authors believe that the intensification of the modernization process of the forms of humanitarian knowledge development will contribute to more efficient formation of common cultural and professional competences of future specialists. Outdated knowledge paradigm is supplanted by a system of methods of students’ creative abilities activation. In the broad context of culture visualization the perception of the thematic blocks of the various Humanities disciplines through active viewing and interpretation of movie passes effectively. Film seminar provides an opportunity to convey educational material in the form of an artistic image; to see the diversity of social and cultural explication of the ideas and values of modernity. The Central concept of the article is built around the creation of new forms of presentation of the lecture material and practical training, which must be problematic and must have the search character to develop the students’ mental activity, to form their cultural competence. The aim of the article is to study and disclosure of the volume meaning and the functional versatility of the cinematic image in the context of the development of the content of the Humanities in higher education. Scientific novelty of the article is opened in the integrative nature of the study. Simultaneously the authors consider, classify, and formulate in the form of methodical recommen- dations: 1) the variety of interpretive practices in the process of understanding the film text; 2) the ability of the cinematic image to accumulate and transmit knowledge about culture, society and man; 3) specific procedures for mastering humanitarian knowledge in the context of global imaging culture.
THE STATE OF THE IMMUNE SYSTEM IN WOMEN IN THE SECOND TRIMESTER OF PREGNANCY AT EXACERBATION OF CHRONIC SIMPLE BRONCHITIS CAUSED BY INFLUENZA A(H3N2)
Authors: Нахамчен Леонид , Nakhamchen Leonid , Гориков Игорь , Gorikov Igor , Колосов Виктор , Kolosov Viktor , Одиреев Андрей , Odireev Andrey , Смирнова Татьяна , Smirnova Tatyana , Колосов Артем , Kolosov Artem
Published: December 2017

The contents of anti-influenza antibodies, secretory immunoglobulin A (sIgA) and circulating immune complexes (CIC) were studied in 145 women in the second trimester of pregnancy. All women were divided into 5 groups. The first group included 30 women with the physiologic course of pregnancy. The second one consisted of 30 patients with chronic simple bronchitis (CB) in remission. The third group had 30 patients with the exacerbation of CB caused by influenza A(H3N2) (antibody titers were 1:16-1:64); the fourth group included 30 patients with CB, whose exacerbation was caused by influenza (antibody titers were 1:32-1:128). It was found out that in the second group there were higher concentrations of sIgA (7.34±0.37 mg/L) and CIC (0.191±0.006 units of optical density), than in the first group (5.86±0.43 mg/L, p<0.05 and 0.095±0.003 units of optical density, respectively, p<0.001). It can probably be explained by the stimulating influence of persistent virus infection on the local immunity and its important role in the development of autoimmune responses in pregnant women. In the fifth group unlike the third group there were registered minimal contents of sIgA: 3.86±0.25 mg/L (p<0.001) and maximal level of CIC: 0.232±0.006 units of optical density (p<0.001). The revealed changes suggested the decrease of local immune protection of airways and autoimmune alteration of a woman’s body caused by high intensity of humoral immunity to influenza virus A(H3N2) under exacerbation of chronic simple bronchitis in patients in the second trimester of gestation.
Linking Staff Burnout to Family Members' Satisfaction in Centers for People With Intellectual Disabilities: A Service Chain Approach
Authors: Moliner Carolina , Lorente Laura , Molina Agustín , Gracia Esther , Martínez-Tur Vicente
Published: December 2017

Research in centers for people with intellectual and developmental disabilities has somewhat neglected the relationship between workers' burnout and users' service evaluations. Two independent survey studies tested this connection. In the first study (100 centers, 714 workers, and 612 family members), results confirmed that burnout has a negative relationship with workers' perceptions of service quality. In turn, these perceptions are associated with the service quality perceptions of family members and their satisfaction with the service. In a replication sample (86 centers, 601 workers, and 819 family members), we reproduced these results and added situational constraints in the model. Both social and technical constraints correlated positively and significantly with burnout. These studies offer a view of the relationships between burnout and service quality.
Prevalência de Doenças Crônicas não Transmissíveis em Idosos de uma Cidade do Interior da Bahia
Authors: Abreu Sanmille Santos Santiago de , Oliveira Andreza Guimarães de , Macedo Maria Aparecida Silva Santos , Duarte Stênio Fernando Pimentel , Reis Luciana Araújo dos , Lima Pollyanna Viana
Published: December 2017

Objetivo: Verificar a prevalência das Doenças Crônicas Não Transmissíveis em idosos de uma cidade do interior da Bahia. Métodos: A pesquisa se classifica como descritiva e exploratória, de natureza quantitativa que foi realizada com 173 idosos de um município do interior da Bahia Foram aplicados dois instrumentos de pesquisa: o Mini Exame do Estado Mental – MEEM e Ficha de doenças pré-existentes – critérios ABCDE. Resultados: Os participantes do estudo foram 173 idosos de 60 anos ou mais de ambos os sexos, 54,91% dos idosos do sexo feminino e 45,09% do sexo masculino. No que se refere à População Feminina, 1,15% auto-referiram ser diagnosticado com a depressão, 15,02% diabetes, 2,89 cardiopatia, 2,89 doença renal, 0,58% câncer, 71,68% hipertensão. Quanto à população masculina auto-referiram ser diagnosticado com diabetes 2,90%, 1,73% cardiopatia, 2,31 câncer e 27,16% hipertensão. Conclusão: Constatou-se que o perfil de morbidades crônicas encontrados na população pesquisada é semelhante ao perfil em idosos no Brasil. Observa-se tendência crescente especialmente na Hipertensão Arterial Sistêmica, Diabetes Mellitus e câncer na população masculina. O estudo demonstrou ainda um quantitativo maior de doenças auto-referidas por mulheres.
Estabilização Segmentar Vertebral no Tratamento de Lombalgia: Uma Revisão Integrativa
Authors: Aguiar Tiago Paixão Nascimento , Santana Júnior Virgílio
Published: December 2017

O objetivo deste estudo é revisar a literatura científica em relação à estabilização segmentar vertebral e seus efeitos na lombalgia. Foi realizada uma busca nas bases de dados LILACS, SciELO e PEDro, no período de outubro a novembro de 2017, a partir do que foram selecionados nove artigos, todos publicados entre 2007 e 2017, os quais abordavam a temática da estabilização segmentar com finalidade terapêutica. Os achados acerca da técnica de estabilização segmentar proporcionaram incremento no tratamento da lombalgia, o que permite concluir que as técnicas demonstraram eficácia com significância na melhora da capacidade funcional, na redução da dor e na prevenção de lesões.
MARITIME CONNECTIONS AND CROSS-CULTURAL CONTACTS BETWEEN THE PEOPLES OF THE NUSANTARA AND THE EUROPEANS IN THE EARLY EIGHTEEN CENTURY
Authors: Niemeijer Hendrik E.
Published: December 2017

In this paper, I would like to discuss two extraordinary tales of two rather ordinary individuals in the service of the Dutch East India Company (henceforth: VOC), the first a Dutchman, Jacob Janssen de Roy, and the second a German, Georg Naporra (1731-1793). It is important to understand that all cross-cultural contacts between the peoples in the archipelago and westerners depended on seaborne trade and the vessels which plied the maritime routes. This was the only means of transportation and communication. As a consequence, cross-cultural contacts took place mainly in the port cities and coastal trading outposts. This can be clearly seen in the cases of our two ordinary Europeans: Jacob de Roy and Georg Naporra.
Consumers and Brands across the Globe: Research Synthesis and New Directions
Authors: Gürhan-Canli Zeynep , Sarial-Abi Gülen , Hayran Ceren
Published: December 2017

Extensive research has investigated branding practices, processes, and consumers’ reactions to brands in a globalized world. In this review, the authors aim to organize and synthesize the growing literature on branding, culture, and globalization from a behavioral perspective by reviewing 129 articles published over 25 years. Specifically, they explicate two perspectives found in the literature: (1) global-local branding and (2) the influence of culture on consumer and brand interactions. The authors identify conceptual gaps in the literature and discuss how new realities in the macro environment (e.g., political issues, digital transformation, environmental concerns) may affect the interaction between culture, brands, and consumers in a globalized world. This review facilitates a more impactful future research agenda in both theory and practice at the interface of branding and globalization from the perspective of behavioral outcomes.
Perceptual Rules for Building Enhancements in 3D Virtual Worlds
Authors: Tutzauer Patrick , Becker Susanne , Haala Norbert
Published: December 2017

While the generation of geometric 3D virtual models has become feasible to a great extent, the enrichment of the resulting urban building models with semantics remains an open research question in the field of geoinformation and geovisualisation. This additional information is not only valuable for applications like Building Information Modeling (BIM) but also offers possibilities to enhance the visual insight for humans when interacting with that kind of data. Depending on the application, presenting users the highest level of detail of building models is often neither the most informative nor feasible way. For example when using mobile apps, resources and display sizes are quite limited. A concrete use case is the imparting of building use types in urban scenes to users. Within our preliminary work, user studies helped to identify important features for the human ability to associate a building with its correct usage type. In this work we now embed this knowledge into building category-specific grammars to automatically modify the geometry of a building to align its visual appearance to its underlying use type. If the building category for a model is not known beforehand, we investigate its feature space and try to derive its use type from there. Within the context of this work, we developed a Virtual Reality (VR) framework that gives the user the possibility to switch between different building representation types while moving in the VR world, thus enabling us in the future to evaluate the potential and effect of the grammar-enhanced building model in an immersive environment.
Common Challenges in Ethical Practice when Testing Technology with Human Participants: Analyzing the Experiences of a Local Ethics Committee
Authors: Brandenburg Stefan , Minge Michael , Cymek Dietlind Helene
Published: December 2017

Ethical aspects are of key importance in research and the development of technical systems. They play a major role when the societal impact of innovative products and new technologies is considered. However, ethics are already essential during technology development, especially when testing these technologies with human participants. The latter is becoming increasingly important when applying for project funding and for publishing peer reviewed journal papers. Responding to these needs, a local ethics committee at the Department of Psychology and Ergonomics at Technische Universität Berlin was founded in 2009. In this paper, we present an analysis of common pitfalls and blind spots that were detected by reviewers of this ethics committee. We studied the reviews of 98 applications for ethical approval. Results show that researchers (a) often lack concrete knowledge about potential ethical issues of their research and (b) that they might benefit from convenient tools to address relevant ethical challenges at early stages of product design. Based on the results of our analysis, we propose a set of six simple rules that can help to detect and to overcome most of the frequently appearing ethical issues.
Was bringen kommunale Gebietsreformen?
Authors: Blesse Sebastian , Rösel Felix
Published: December 2017

Seit Jahrzehnten werden kommunale Gebietskörperschaften fusioniert, in der Hoffnung auf Kosteneinsparungen und eine höhere Leistungsfähigkeit der Verwaltung. In diesem Beitrag geben Sebastian Blesse und Felix Rösel einen Überblick über die bestehende kausale Evidenz zu den Effekten von Gebietsreformen auf öffentliche Ausgaben, Effizienz und Qualität der Verwaltung sowie zu den möglichen politischen Folgen der Zusammenschlüsse. Sie zeigen, dass Evaluationsstudien selten Effizienzrenditen von Gebietsreformen nachweisen. Allerdings ergeben sich unbeabsichtigte Nebenwirkungen auf die politische Partizipation: Die Bürger sind weniger zufrieden mit der Demokratie und gehen seltener zur Wahl, und die Ungleichheit zwischen den Ortsteilen nimmt zu. Vor diesem Hintergrund erörtern die Autoren alternative Instrumente wie interkommunale Zusammenarbeit, Funktionalreformen und Maßnahmen der Verwaltungsmodernisierung.
Simulation of seismic processes in geological exploration of Arctic shelf
Authors: Stognii Polina V. , Petrov Dmitriy I. , Khokhlov Nikolai I. , Petrov Igor B.
Published: December 2017

The paper presents the results of application of a grid-characteristic method to simulation of wave processes in media with linearly-elastic and acoustic layers on the example of seismic exploration of the Arctic shelf. The grid-characteristic method correctly describes the contact and boundary conditions. The results of numerical simulation are presented, the method is shown to be applicable to solution of seismic exploration problem on the Arctic shelf.
A Test Protocol for Evaluating Absorption of Joints in Concrete Pavements
Authors: Tiznobaik M. , Bassuoni M. T.
Published: December 2017

Premature deterioration at joint spresents a critical durability issue of concrete pavements associated with considerable repair costs. Durability of concrete exposed to aggressive environments depends mainly on the penetrability of its pore structure. Because absorption has been used as an important indicator for quantifying the durability of concrete, the aim of this study was to develop a customized test protocol for determining the absorption capacity of joints in concrete pavements. The study involved three phases with thorough statistical analyses of results. In Phase I, different absorption procedures were applied to laboratory specimens prepared with water-to-binder ratios (w/b) of 0.3, 0.5, and 0.6, representing variable qualities of concrete. The most efficient procedure was identified from Phase I and further verified in Phase II on concrete specimens prepared with a close range of w/b (0.35 and 0.40). In Phase III, the performance of the absorption protocol selected from the previous phases was assessed on cores extracted from recently constructed pavement sections in Winnipeg, Manitoba, Canada. To further complement and verify the trends obtained from the absorption protocol, mercury intrusion porosimetry tests were conducted on the field cores to capture the characteristics of the pore structure. The results indicated that the proposed absorption protocol was efficient, robust, and reliable in reflecting the physical features of the microstructure of field pavement sections, including joint locations.
MT3-MMP Promotes Excitatory Synapse Formation by Promoting Nogo-66 Receptor Ectodomain Shedding
Authors: Sanz Ricardo L. , Ferraro Gino B. , Kacervosky Johannes , Salesse Charleen , Gowing Elizabeth , Hua Luyang , Rambaldi Isabel , Beaubien Francois , Holmbeck Kenn , Cloutier J.F. , Lévesque Martin , Murai Keith , Fournier Alyson E.
Published: December 2017

Cell-surface molecules are dynamically regulated at the synapse to assemble and disassemble adhesive contacts that are important for synaptogenesis and for tuning synaptic transmission. Metalloproteinases dynamically regulate cellular behaviors through the processing of cell surface molecules. In the present study, we evaluated the role of membrane-type metalloproteinases (MT-MMPs) in excitatory synaptogenesis. We find that MT3-MMP and MT5-MMP are broadly expressed in the mouse cerebral cortex and that MT3-MMP loss-of-function interferes with excitatory synapse development in dissociated cortical neurons and invivo. We identify Nogo-66 receptor (NgR1) as an MT3-MMP substrate that is required for MT3-MMP-dependent synapse formation. Introduction of the shed ectodomain of NgR1 is sufficient to accelerate excitatory synapse formation in dissociated cortical neurons and invivo. Together, our findings support a role for MT3-MMP-dependent shedding of NgR1 in regulating excitatory synapse development.

SIGNIFICANCE STATEMENTIn this study, we identify MT3-MMP, a membrane-bound zinc protease, to be necessary for the development of excitatory synapses in cortical neurons. We identify Nogo-66 receptors (NgR1) as a downstream target of MT3-MMP proteolytic activity. Furthermore, processing of surface NgR1 by MT3-MMP generates a soluble ectodomain fragment that accelerates the formation of excitatory synapses. We propose that MT3-MMP activity and NgR1 shedding could stimulate circuitry remodeling in the adult brain and enhance functional connectivity after brain injury.