bluuebunny/crossref_metadata_2025 huggingface dataset:
Fusobacterium nucleatum: a new player in regulation of cancer development and therapeutic response
Authors: Zhao Tengda , Wang Xueping , Fu Liwu , Yang Ke
Published: May 2022

A dysbiosis in microbial diversity or functionality can promote disease development. Emerging preclinical and clinical evidence emphasizes the interplay between microbiota and both disease evolution and the treatment response of different cancers. One bacterium that has garnered much attention in a few cancer microbiota studies is Fusobacterium nucleaum (Fn). To provide updated knowledge of the functional role of Fn in cancer prevention and management, this review summarizes the relationship among Fn, cancer, and chemoimmunotherapy response, with the potential mechanisms of action also intensively discussed, which will benefit the development of strategies to prevent or treat cancer via Fn-based therapeutic interventions.
Sampled-based bipartite tracking consensus of nonlinear multiagents subject to input saturation
Authors: Yu Luyang , Cui Ying , Lu Zongya , Liu Yurong
Published: May 2022

This paper is concerned with the sampled-data bipartite tracking consensus problem for a class of nonlinear multiagent systems (MASs) with input saturation. Both competitive and cooperative interactions coexist among agents in the concerned network. By resorting to Lyapunov stable theory and linear matrix inequality (LMI) technique, several criteria are obtained to ensure that the considered MASs can achieve the bipartite tracking consensus. Besides, with the help of the decoupled method, the dimensions of LMIs are reduced for mitigation of the computation complexity so that the obtained results can be applied to large-scaled MASs. Furthermore, the controller gain matrix is explicitly expressed in terms of solutions to a set of LMIs. We also provide with an estimate of elliptical attraction domain of bipartite tracking consensus. Finally, numerical simulation is exploited to support our theoretical analysis.
ЧИННИКИ СТРАТЕГІЧНОГО УПРАВЛІННЯ ЕКОНОМІЧНОЮ БЕЗПЕКОЮ ПІДПРИЄМСТВА В УМОВАХ ЗМІН
Authors: Ковальчук А. М.
Published: May 2022

У статті досліджені деякі підходи до визначення впливу чинників на стратегічне управління економічною безпекою підприємства. Нинішні умови розвитку економіки країни загалом та підприємств зокрема характеризуються значною кількістю чинників, які впливають на систему забезпечення економічної безпеки підприємства у стратегічному полі. Змінні умови формують чинники стратегічного управління економічної безпеки підприємства, які потребують постійного аналізу, моніторингу та доповнення. Метою дослідження є визначення основних чинників стратегічного управління економічною безпекою в умовах адаптивності підприємства до змін. У статті теоретико-методологічною основою дослідження впливу чинників на стратегічне управління економічною безпекою підприємства є основні положення наукових досліджень вітчизняних вчених. Методами, що було використанні у процесі дослідження є порівняння та систематизація – для виявлення основних тенденцій об’єкта дослідження; абстрактно-логічний та узагальнення – для виділення результатів та висновків поведеного дослідження. Виявлено, що стратегічне управління економічною безпекою підприємства – це система довготривалих та стійких управлінських рішень та процесів задля забезпечення оптимального стану захищеності економічних інтересів підприємства у тактичному періоді та розвитку у довготривалих періодах. На основі проведеного аналізу підходів до визначення чинників стратегічного управління економічної безпеки визначено взаємозв’язок між чинниками, функціями та цілями системи управління економічної безпеки та його стратегічним розвитком. В результаті дослідження запропоновані ознаки класифікації чинників сучасного стратегічного управління економічною безпекою відповідно до умов, що склалися. Запропонована класифікація дозволяє виявити тенденції впливів чинників на стратегічне управління економічною безпекою; виявити основні загрози економічній безпеці підприємств, які мають стратегічний характер. У зв’язку із постійним характером змін середовища в якому функціонують підприємства необхідно зауважити, що класифікація чинників є невичерпною та може доповнюватись відповідно до умов.
СУЧАСНЕ ПРОГРАМНЕ ЗАБЕЗПЕЧЕННЯ ДЛЯ ЗДІЙСНЕННЯ БІЗНЕС-АНАЛІЗУ
Authors: Задорожнюк Н.О.
Published: May 2022

У статті розглянуто популярні методи прийняття управлінських рішень в сучасних компаніях: метод аналізу ієрархій; використання нейронних мереж; теорія нечітких множин; нейро-нечітке моделювання та теорія ігор. Визначено переваги та недоліки кожного з розглянутих методів прийняття управлінських рішень в компаніях. У роботі доведена необхідність використання сучасного програмного забезпечення для здійснення бізнес-аналізу компаній. Відокремлено програмне забезпечення відповідно до кожного методу прийняття управлінських рішень: QlikView; Loginom; Contour BI; Power BI та Business Scanner. Визначено комплексні ціни на розробку індивідуального бізнес-рішення з урахуванням впровадження розглянутого у статті програмного забезпечення. Визначено ціни програмного забезпечення без вартості установки та з урахуванням його установки для фізичних та юридичних осіб. Також в комплексній ціні на розробку індивідуального бізнес-рішення включено ціну адміністрування програмного забезпечення за місяць (підтримка, перевірка і налаштування кожного програмного продукту). В статті також здійснено порівняння функціоналу досліджуваного програмного забезпечення за наявністю таких функцій: можливість експорту звітів; новітні можливості формування звітності; наявність панелі моніторингу; врахування нерегламентованої звітності; забезпечення регулярності звітності; можливість імпорту та експорту даних; забезпечення доступу до звітності декількох користувачів; візуалізація даних; здійснення бізнес-аналітики; можливість адміністрування; наявність АРІ; забезпечення збалансованої системи показників (BSC); здійснення аналітики самообслуговування. Наукова новизна роботи відображена у визначені сучасного програмного забезпечення відповідно до кожного з популярних метода прийняття управлінських рішень. Практична значущість роботи полягає у можливості вибору програмного забезпечення компаніями для здійснення бізнес-аналізу на основі таких параметрів: комплексної ціні на розробку індивідуального бізнес-рішення та функціоналу досліджуваного програмного забезпечення.
The effectiveness of using hydrated carrot and beet powders inthe production of round cracknels sourdough
Authors: Tikhiy A. V. , Barakova N. V. , Samodelkin E. A.
Published: May 2022

Two methods of adding carrot and beet powders to the sourdough of round cracknel products have been studied, such as adding the dry powders and adding the pre-hydrated ones. The water-retaining properties of carrot and beet powders and the change in the lifting force of yeast when applying non-hydrated and hydrated powders before fermentation were investigated. For the experiment, we used Vitbiokor LLC carrot and beet powders. The average integral particle size in carrot powder was 85-95 microns, in beet powder —95-105 microns. We also used the flour of the highest grade Predportovaya(produced by Saint Petersburg Mill Plant, JSC) and the pressed baking yeast produced by Food Combine, JSC. The particle size of the powders was determined by a Malvern Mastersizer 2000 laser diffraction analyzer. The water-holding capacity of the powders was determined by a hydromodule of 1:10 by centrifugation with the rotational speed 6000rpm-1,for 20 minutes (the carrot powder samples) and for 15 minutes (the beet powder samples). The lifting force of the yeast has been determined with the help of the "pop-up ball" method. The powders were hydrated at a hydromodule of 1:5, at a temperature of 30°C for 60 minutes. The results show that carrot powders aged for 40 minutes and beet powders (33%) aged for 40 minutes have the maximum water retention capacity (43%). It was found that the quantity of carrot and beet powders added does not correlate with the lifting force of the yeast in the sourdough samples. It is higher in the samples with the hydrated powders added, rather than in the ones with the non-hydrated powders. Moreover, this difference was more pronounced in the beet powder samples. The study shows the importance of carrot and beet powders hydration before adding them to the sourdough. It’s also significant to conduct the experiments to evaluate the effectiveness of carrot and beet powders hydration before adding them to the round cracknel products sourdough
Choosing microelements for the immobilization of their colloidal frames on a natural carrier in order to enrich the main food products
Authors: Belokurova E. V. , Popov E. S. , Sargsyan M. A.
Published: May 2022

The development and implementation of new technologies for enriching the finished product with trace elements is important and relevant. Deviations in the elemental state of the body are found in the vast majority of the adult population of Russia, significantly differing in nature and degree of severity in representatives of different regions and persons divided by profession and occupation. At the same time, it is recognized that in Russia, on average, about two-thirds of adults and three-quarters of children are classified as at risk for hypomicroelementosis, on the other hand, about one-third of the population is more or less susceptible to hypermicroelementosis. The most common deficiency of trace elements such as iron, zincum, copper, chromium, iodine, selenium, cobalt, silicium. The main problem of detecting microelementosis is that the deficiency of essential elements does not have a pronounced clinical picture. To correct the finished formulations of products, it is necessary to take into account the indicators of the level of absorption and the rate of release of these elements, as well as ways of their disposal in the body. One of the most effective ways to introduce essential and conditionally essential elements into formulations is the immobilization of colloidal solutions with a high content of these elements on a polymeric materialor protein carrier, followed by introduction into the composition of the prepared product. The efficiency of using elements such as silver, gold, zinc, cobalt and selenium as a colloidal phase is described. Antagonistic and synergistic interactions of essential elements, their effect on the body, taking into account the indicators of absorption and the rate of their excretion, are described.
Effect of food additives on the structure of the dough
Authors: Vasyukova A. T. , Kusova I. U. , Alekseev A. E. , Moshkin A. V. , Lyubetskaya T. R.
Published: May 2022

The article presents data on the effect of additives of pre-processed powder from plant raw materials on the structure of yeast dough. Inthe activityof malt from rye, wheat, barley of the "Elf" variety, soybeans, peas and triticale, depending on different concentrations of the substrate. Two important characteristics are obtained – the Michaelis constant and the dependence of the reaction rate on the concentration of substratea. Studies of the amylolytic activity of tritical malt on wheat flour have shown that the sugar-forming ability of flour increases with the addition of dry tritical malt. When carrying out a reaction using not distilled, but tap water, the activity of amylase increases even more, which is not unexpected in accordance with the experiments conducted. The greatest significance of the processes occurring during the kneading of the test: physico-mechanical, colloidal and biochemical can be explained by the swelling of water-insoluble proteins, which form a three-dimensional spongy-mesh structure in the dough. This determines the extensibility and elasticity of the dough. Starch grains of flour adsorption binds a large amount of water. A significant amount of water is also absorbed by rye flour penthozans. The highest value of acidity was characterized by samples with rye malt, introduced in a dosage of 1–3% by weight of flour. The introduction of malt preparation was also reflected in the structural and mechanical properties of the crumb. Elastic deformations with an increase in the dosage of malt are reduced, in contrast to plastic deformations. For use in baking, according to a comprehensive assessment, barley malt is recommended at a dosage of 3% to the mass of flour.
The contribution of social audit to the social performance of companies
Authors: Djebbouri K. W. , Boutouatou A. , Khorev A. I. , Ivliyev M. N.
Published: May 2022

Today's economic climate, characterized by globalization and market liberalization, has forced modern markets, forced modern companies to live in a highly competitive environment. Therefore, in this volatile and uncertain environment, a company must optimize its available resources, and in particular human capital, which is a fundamental source of value creation and value and wealth creation. Human capital is a strategic lever of competitiveness that companies must Human capital is a strategic lever of competitiveness that companies must take into account. Site Companies are not left out; like all companies in the world, they must also be aware of the importance of this factor and its direct impact on organizational effectiveness. This is achieved through better management of human capital and through various tools, in this case the social audit. This tool is the most privileged to implement because it allows an inventory of the human resource management function and remains the best ally for reducing the social risks faced by companies. This tool is the most privileged to implement because it allows an inventory of the human resources management function and remains the best ally to reduce the social risks faced by companies. Our study serves to offer an overview of the literature on social auditing and social performance. Thus, we seek to answer the question of the contribution of social audit to a company's social performance by revealing different theoretical models that understand this relationship (social audit and social performance.
The effect of innovation on economic growth in the BRICS countries using Panel Data estimation
Authors: Djebbouri K. W. , Boutouatou A. , Khorev A. I. , Ivliyev M. N.
Published: May 2022

The aim of the study is to find out how innovation affects economic growth in the BRICS countries. The World Bank 2021 World Development Indicators database, covering the period from 2000 to 2019, was used to collect data. There are three ways to quantify innovation: research and development, patents, and trademarks. This study looked at how the GDP of the BRICS countries responds to the hit from research and development, patents, and trademarks. Stationarity tests are conducted using panel unit-roots. For the study, the authors used both multiple regression for each country and panel data regression estimates for the BRICS countries. The authors suggest several compelling factors for BRICS economies to examine the development of innovation, especially in research and development, patents, and trademarks, as a potential opportunity to accelerate economic growth. Furthermore, the authors found that the overall impact of research and development, patents, and trademarks on economic growth is significant and growing rapidly among the BRICS economies, demonstrating that innovation contributes significantly to economic growth. The results of this study show that research and development, patents, and trademarks are important drivers of innovation and, therefore, GDP growth in the BRICS region.
Formation of innovative industry development
Authors: Tretyakova L. A. , Azarova N. A. , Puzakov R. N.
Published: May 2022

In the current conditions of economic development, the formation of innovative sectoral development is provided on the basis of the global implementation of human capital. In the situation of economic crises due to the instability of the external environment, human capital is the only source and resource for innovative changes in economic processes. Therefore, we propose to consider the indicator "human capital" as the basis for major innovative changes in the growth of modern Russian economy, which has been investigated in this article. The actualization of modern innovation policy, which includes guidelines for the development of the Russian Federation towards an innovation-technologically developed path, has determined the particular importance of the "human capital" indicator. The authors have highlighted the methodology for investigating the synergy of these research aspects. In the paper a conclusion is drawn, that taking into account imperfection of existing conceptual positions concerning a role and value of the human capital in the course of forming of innovative branch development for the purpose of increase of innovative activity of all participants of branch economic system and maintenance of influence on intensive development of branches and complexes, it is necessary to provide objective revision of traditional approaches of branch development research. The given research will allow increasing innovative activity of all participants of branch industrial-economic system. At the same time, human potential acts as the main driving force and asset of ensuring sustainable and intensive sectoral development, determines the opportunities of sectoral production and economic systems for the formation of diversification directions The structural and logical scheme of ensuring innovative sectoral development, which includes the stages of innovative development, such as the stage of forming prerequisites for innovative sectoral development, the stage of realization of human potential in the industry, the stage of realization of aggregate.
Paediatric Pineal Region Cysts: Enigma or Impaired Glymphatic Neurofluid System?
Authors: Ludwig Hans , Dreha-Kulaczewski Steffi , Bock Christoph
Published: May 2022

Proposal: Pineal region cysts (PCs) may affect the tectum and aqueduct and cause deep central vein congestion and endocrine dysfunction. In addition to headaches, PC often causes a broad range of symptoms, leading to prolonged diagnosis and therapy. The aims of this study are to reveal parameters that might explain the ambiguity of the symptoms and to identify factors association with the respiration driven neurofluid preload system. Methods: This retrospective study included 28 paediatric patients (mean age 11.6 years) who received surgical treatment for pineal region cysts and 18 patients (mean age 11.3 years) who were followed conservatively. Multiple clinical patient characteristics, such as symptoms, time to neuroimaging diagnosis, cyst size, ventricular indices, head circumference and postoperative outcome, were analysed. Four patients were investigated for CSF dynamics with real-time MRI. The mean follow-up time was 1.6 years. Results: The most common early onset symptoms were headaches (92%), blurred vision (42.8%), sleep disturbances (39.3%) and vertigo (32.1%). Tectum contact was observed in 82% of patients, and MRI examinations revealed that imaging flow void signals were absent in 32.1% of patients. The mean cyst diameters were 13.7 mm for the axial axis and 15.6 mm for the longitudinal axis. Together with a postoperative flow void signal, 4 patients recovered their respiration-driven CSF upward flow, which was not detectable before OP. After operation in 92.1% of patients, the leading symptoms improved without any mortality or morbidity. Conclusion: Despite proximity to the tectum and aqueduct with frequently absent aqueductal flow void signals, hydrocephalic ventricular enlargement was never detected. Data from real-time MRI depicted a reduced preoperative filling of the ventricular CSF compartments, indicating a diminished fluid preload, which recovered postoperatively.
Microbial Models for the Evolution of Predator-Prey Interactions
Authors: Schaal Kaitlin A.
Published: May 2022

Predation is a driving force of organismal ecology and evolution. Predator-prey interactions, constrained by other environmental factors and historical contingency, shape physical and behavioral phenotypes of organisms on both sides of the interaction arrow. Yet despite the universality of trophic interactions in biology, study of the ecology and evolution of anti-predator defense is challenging because these interactions tend to be brief and unpredictable, and thus gathering direct evidence requires patience and serendipity. The evolution of prey defenses can be studied by DNA sequencing followed by phylogenetic analysis, and the ecology can be studied by field observation and bringing tractable systems into the lab. However, animal models generally do not allow genetic manipulation, strict control of environmental variables, or detailed observation of evolution in real time, all of which are important for demonstrating evolutionary causes and consequences. Developing complementary microbial predator-prey systems can help overcome this hurdle. There is an extensive body of work on microbial experimental evolution, and many microbes come with well-characterized genomes and established methods for genetic manipulation. As understanding of microbial ecology and the mechanisms of their trophic interactions grows apace, these systems are poised to make valuable contributions to our understanding of how predator behaviors evolve, why certain anti-predator defenses evolve and not others, and how multiple defenses function together in a single defense portfolio. These systems will enable us to both test hypotheses formulated from the study of larger organisms and to propose new ones that can be tested in larger organisms with existing methods.
Are students too anxious for statistics anxiety workshops?
Authors: Marshall Ellen , Riach Anna , Shaker Amanda J , Haigney Diane
Published: May 2022

Statistics is a widely taught subject in Higher Education but for many students, anxiety about statistics interferes with the learning process. Statistics anxiety workshops to help students understand and reduce statistics anxiety were developed by the authors and in 2020/21 delivered collaboratively and remotely with specific cohorts of students at three institutions. Prior to the workshops, all students within the targeted cohorts were asked to complete a survey which included measures of statistics anxiety, and asked if they were interested in attending the voluntary workshop. This enabled a comparison of the characteristics of groups who were interested or not. The workshops successfully attracted the targeted students, since those attending had higher overall statistics anxiety, software and maths anxiety, and anxiety around learning statistics. However, students with higher help seeking anxiety were less likely to attend.
Celebrating our past: once upon a time there was a cottage industry. Personal reflections on the development of mathematics support
Authors: Croft Tony
Published: May 2022

Back in the early 1990's mathematics support was small-scale and loosely organised. Now, in 2021, it is to be found in the full range of university mission groups including those with the highest entry requirements. Today it is undoubtedly true that support centres are part of the landscape of higher education. They have evolved from offering local, drop-in support to first-year engineers to university-wide centres offering help to students in all disciplines and at all levels including postgraduates and sometimes staff. They contribute to university-wide priorities including recruitment, progression, retention, satisfaction, quality enhancement and employability. They have succeeded in raising issues such as the mathematics support of students with additional needs higher up institutional agendas and have firmly put the activities of those who work in this field on the radar of senior management of universities. This paper charts key milestones and events from the trajectory of mathematics support from 1990 to 2020 which have resulted in the thriving support services and community of practitioners that are evident today. It is based on a keynote presentation given by the author at CETL MSOR 2021.
PeerWise: Students creating questions for their peers
Authors: Ketnor Claire , Shaker Amanda , Raghupati Karishma , Pham Van Tien
Published: May 2022

PeerWise (https://peerwise.cs.auckland.ac.nz/) is a system which allows students to create multiple-choice questions for other students, answer questions posed by their peers and then provide feedback (Denny et al, 2008). There is evidence in the literature to show this method of assessment has a positive impact (e.g., Guilding et al. 2021; Fergus et al. 2021; Feeley and Parris 2012), particularly on students’ attainment and engagement. In a funded project, we introduced PeerWise into the assessment for a module at Sheffield Hallam University (U.K.) and another at La Trobe University (Australia). In this case study, we give an overview of PeerWise and the activities within the platform, results from our evaluation of the activity, and advice for implementation collected within the project from other practitioners around the world who have experience using PeerWise. Cohesive themes arising from our evaluation and the advice collected are summarised to form recommendations for improved student experience and outcomes, for future implementation of the PeerWise platform by practitioners.
Accessible teaching with GNU TeXmacs
Authors: Wouters Jeroen
Published: May 2022

In this article I give a brief overview of some of the challenges in creating accessible documents for STEM education, as well as why and how GNU TeXmacs can be used to address some of these.
The effect of scheduling on attendance at synchronous online support tutorials in mathematics
Authors: Pawley Susan
Published: May 2022

Optional synchronous online support (SOS) tutorials play a key role in student success. However, with the additional pressures of external commitments on students are the “traditional times” of offering study support the optimal times?Following on from the trends in increased availability of mathematical support (Grove et al 2019) we have piloted a model that focusses on providing different SOS tutorials based on, time of day, study speed and study programme.The results of this pilot show, that whilst traditional times still attract the highest attendance, by offering a variety of SOS tutorials overall engagement can be significantly increased.
ANALISIS DAYA SAING JAGUNG HIBRIDA UNGGUL MADURA MH-3 DI KABUPATEN BANGKALAN
Authors: Rahmaniyah Fatihatur , Rum Mokh.
Published: May 2022

Produksi jagung nasional mengalami tren kenaikan pada 2017 sebesar 28,9 juta ton dari produksi sebelumnya. Penambahan produksi jagung yang tidak sebanding dengan permintaan jagung, dibutuhkan impor jagung dari luar negeri. Ketergantungan impor menurunkan minat petani untuk berusahatani sehingga dibutuhkan upaya peningkatan daya saing. Penelitian ini bertujuan untuk menganalisis daya saing jagung hibrida unggul madura MH-3 ditinjau dari keunggulan komparatif dan kompetitif di Kabupaten Bangkalan dan menganalisis pengaruh kebijakan pemerintah terhadap komoditas jagung hibrida unggul MH-3 di Kabupaten Bangkalan. Metode penelitian menggunakan Policy Analysis Matrix dengan teknik pengambilan sampel jenuh (sensus) yaitu keseluruhan petani yang berusahatani jagung hibrida unggul Madura MH-3. Hasil penelitian menunjukkan usahatani jagung hibrida unggul Madura MH-3 di Kabupaten Bangkalan berdaya saing secara komparatif dan kompetitif. Dilihat dari aspek biaya, jagung hibrida unggul madura MH-3 dapat ditingkatkan dengan memperbaiki teknologi budidaya dan meningkatkan efisiensi. Petani diuntungkan dengan kebijakan harga output sehingga penerimaan privat yang diperoleh petani lebih tinggi. Dibutuhkan adanya perluasan mitra kerja untuk memperbaiki mekanisme pasar baik input atau output, agar petani lebih bergairah untuk meningkatkan produksi jagung.
PERAN KELEMBAGAAN PADA USAHA SAPI MADURA DITINJAU DARI ASPEK KULTURAL DAN STRUKTURAL
Authors: Firmansyah Muchammad Diky , Sunyigono Andrie Kisroh
Published: May 2022

Peran kelembagaan pada usaha sapi Madura diharapkan akan meningkatkan produktifitas usaha. Tujuan dari penelitian ini adalah (1) untuk mengetahui kelembagaan dan karakteristik usaha sapi Madura, (2) untuk mengetahui peran kelembagaan pada usaha sapi Madura yang ditinjau dari aspek kultural dan struktural. Penelitian ini dilaksanakan di Kecamatan Geger merupakan daerah yang memiliki usaha ternak sapi potong terbesar di Kabupaten Bangkalan.  Metode penelitian yang digunakan yaitu analisis deskriptif menggunakan skala likert dan analisis regresi logistik ordinal. Hasil penelitian dari peran kelembagaan pada usaha sapi Madura terdapat peran aktor kelembagaan yang dapat menunjang kegiatan usaha peternakan sapi di Kecamatan Geger, diantaranya peran kepala desa sebagai fasilitator untuk menerima dan membantu keluhan yang terdapat di usaha peternakan sapi. Aktor pemeritah daerah yang bertugas sebagai penyalur bantuan pemerintah dalam perekonomian peternak. Aspek yang paling berpengaruh dalam peran kelembagaan pada usaha sapi potong adalah aspek struktural, dimana terdapat item keanggotaan dan kepemimpinan. Hal tersebut karena kecenderungan dari responden yang lebih memilih menyukai item keanggotaan dan kepemimpinan yakni keterlibatan responden dan keikut sertaan responden dalam pengambilan keputusan.
PREFERENSI KONSUMEN TERHADAP PRODUK MINUMAN KOPI DI KOPI JANJI JIWA JILID 324 SURABAYA
Authors: Rohmah Alsa Nailur , Subari Slamet
Published: May 2022

Peningkatan konsumsi kopi terus terjadi di masyarakat Indonesia. kopi tidak hanya dinikmati oleh beberapa golongan, namun kopi dapat dinikmati oleh seluruh kalangan lintas generasi dan gender. Janji jiwa merupakan salah satu kedai kopi sekaligus brand yang ada di Indonesia dan telah dibuka sejak tahun 2018 serta cukup menyita perhatian publik. Namun, seiring dengan perkembangan waktu, jumlah kedai kopi di Indonesia semakin menjamur dan persaingan bisnis semakin ketat, sehingga untuk mempertahankan eksistensinya, Kopi Janji Jiwa perlu memahami kebutuhan dan keinginan konsumen akan kopi. Tujuan dari penelitian ini adalah: (1) Mengetahui karakteristik konsumen, (2) Atribut apa saja yang menjadi pilihan konsumen dalam membeli minuman kopi di Kopi Janji Jiwa Jilid 324 Surabaya. Metode penelitian menggunakan analisis deskriptif dan analisis conjoin. Hasil yang diperoleh menunjukkan karakteristik konsumen sebagian besar usia 17-25 tahun dengan pendidikan perguruan tinggi, pekerjaan pelajar/mahasiswa dan penghasilan Rp.1.000.000-Rp.1.500.000. Atribut yang menjadi pilihan konsumen yakni kopi dengan varian es kopi susu, topping ice cream, rasa manis dengan harga Rp. 23.000.
EFISIENSI EKONOMI USAHATANI KACANG HIJAU DI DESA TANJUNGHARJO KECAMATAN KAPAS KABUPATEN BOJONEGORO
Authors: Faiz Ahmad Wildan , Fauziyah Elys
Published: May 2022

Kacang hijau menjadi komoditas pilihan yang selalu dibudidayakan oleh sebagian besar petani di Desa Tanjungharjo, setelah mereka membudidayakan padi di sawah. Permasalahan yang dihadapi adalah tingkat produktivitas usahatani kacang hijau masih rendah. Penelitian ini dilakukan dengan dua tujuan yaitu menganalisis faktor produksi dan tingkat efisiensi ekonominya. Sampel yang dipergunakan sebanyak 70 orang, Fungsi produksi Cobb Douglas dimanfaatkan untuk menganalisis tujuan penelitian. Hasil analisis menunjukkan terdapat 2 faktor yang mempengaruhi produksi kacang hijau dan penggunaannya belum efisien secara ekonomis yaitu benih dan pupuk cair.
Studi Penetapan Komoditi Unggulan Tanaman Perkebunan di Kabupaten Sumenep Provinsi Jawa Timur
Authors: Syahfera Nelsi Ega , Sunyigono Andrie Kisroh
Published: May 2022

Perkebunan adalah salah satu sektor pemulihan ekonomi paska krisis yang mampu memberikan kontribusi serta dinilai mampu bertahan secara signifikan,namun beraneka ragam dari tanaman perkebunan yang di budidayakan di Kabupaten Sumenep belum diketahui terkait jenis tanaman perkebunan yang mampu menciptakan produk unggulan daerah. Penelitian ini bertujuan untuk mengetahui komoditas unggulan sub sektor perkebunan di Kabupaten Sumenep, mengetahui komoditas unggulan sub sektor perkebunan yang mampu tumbuhcepat di Kabupaten Sumenep, dan mengetahui komoditas unggulan sub sektor perkebunan yang mampu berdaya saing di Kabupaten Sumenep.Data yang dipakai pada penelitian ini merupakan data sekunder berupa produksi komoditas sub sektor  perkebunan Kecamatan di Kabupaten Sumenep dengan time series tahun (2014 – 2019). Metode analisis data yang dipakai adalah Location Quotient (LQ) dan Shift Share. Hasil analisis menunjukkan bahwa komoditas unggulan di Kabupaten Sumenepyaitu kelapa, jambu mete, kapok randu, siwalan, asam jawa, cabe jamu, lada, serat nanas, pinang, kopi, kenanga, dan melinjo.Sedangkan komoditas unggulan sub sektor perkebunan dengan pertumbuhan cepatadalah kapok randu, Siwalan, pinang, jambu mete, lada, kenanga, dan kopi.Sementara untuk komoditas unggulan sub sektor perkebunan yang mampu berdaya saing antara lain siwalan, cabe jamu, jambu mete, serat nanas, kenanga, pinang, kelapa, lada, kopi, dan asam jawa.
Persepsi Masyarakat terhadap Kondisi Sumber Daya Alam guna Mendukung Usaha Pertanian Berkelanjutan di Desa Duber, Kecamatan Supiori Timur, Kabupaten Supiori
Authors: Ronsumbre Valentinday , Ihsannudin Ihsannudin
Published: May 2022

Sumber daya alam (SDA) memegang peran penting bagi kesejahteraan suatu wilayah. SDA yang dikelola dengan baik dapat menghasilkan nilai tambah serta modal daya saing ekonomi secara berkelanjutan. Pengelolaan  SDA secara berlebihan dapat memberikan efek negatif bagi ekosistem sekitar, dengan demikian dapat menghambat pembangunan pertanian berkelanjutan. Disisi lain, persepsi masyarakat menjadi tolak ukur dalam peerencanaan pengelolaan SDA berkelanjutan. Tujuan dari penelitian ini adalah mengetahui persepsi masyarakat terkait SDA yang memiliki nilai kepentingan dan keterancaman. Penelitian ini dilaksanakan di Desa Duber, Kecamatan Supiori Timur, Kabupaten Supiori. Penelitian ini menggunakan pendekatan kuantitatif diskriptif, dengan metode  sampling purposive pada 91 responden. Penilaian persepsi masyarakat terhadap nilai kepentingan dan keterancaman sumberdaya diadaptasi dari gagasan Reymon et al. (2009) yang terdiri 13 jenis sumber daya. Data dianalisis menggunakan metode analisis frequensi diskriptif. Hasil penelitian menunjukkan bahwa SDA yang dipersepsikan sangat penting adalah pantai. Selanjutnya SDA yang dipersepsikan sangat terancam berturut turut adalah pantai, hutan lahan basa (mangrove), dan sungai. Terdapat pandangan pada pantai dan sungai yang dipersepsikan sangat penting tetepi juga sangat terancam sekaligus. Hal ini dikarenkan kurangnya kesadaran, minat, serta rendahnya pemberdayaan terhadap masyarakat setempat. Maka saran yang diberikan adalah kesedaran dan minat masyarakat perlu ditingkatkan lagi, baik masyarakat Duber maupun masyarakat diluar Duber. Selain itu perlu adanya penegakan regulasi, keikutsertaan masyarakat dalam pembuatan kebijakan serta pemberdayaan dari pemerintah dalam mendukung upaya pertanian berkelanjutan.
An Efficient Localized Nonlinear Solver for Simulating Natural Depletion of Unconventional Reservoirs with Complex Fracture Networks
Authors: Jiang Jiamin , Wen Xian-Huan
Published: May 2022

Simulating unconventional reservoirs efficiently and accurately poses a big challenge. Transient flow can last for a long period and sharp solution gradients appear because of the severe permeability contrast between fracture and matrix. Although high-resolution well and fracture models are required to achieve sufficient accuracy, they are computationally too demanding for field models with many hydraulic-fracture stages.

This paper aims to develop a nonlinear solution method, which is applicable to discrete fracture models (DFMs) for unconventional reservoirs. The localization algorithm takes advantage of solution locality on timestep and Newton iteration levels. We study the new method through multiple natural-depletion cases containing discrete fractures and compositional models. It is found that a large extent of solution locality displays over iterations as well as timesteps. The developed nonlinear solver exhibits outstanding simulation efficiency compared with a standard solver. A significant speedup is achieved by focusing computations to the locales that undergo considerable solution changes. Moreover, nonlinear convergence performance is maintained, with no degradation of the solution results.
An Analysis of Automatic Closed-Loop Control of Rotary Drive Engines
Authors: Young F. S. , Sampson T. J.
Published: May 2022

On drilling rigs equipped with an independent and mechanically driven rotary table, rotary speed is often found to be torque sensitive. This paper describes an automatic control system designed for use on these mechanical rigs to compensate for rotary speed variation with load.

Transfer functions for a loaded rotary table were developed using basic closed-loop control theory, and the components of the resulting control system are discussed. An analysis of the proposed system demonstrating optimum response and stability is given. The design objective of maximum dampening of speed variations without oscillation is demonstrated by simulation.

From this development, it has been concluded that a relatively simple control loop is sufficient for automating a rotary drive engine by positioning a pneumatic throttle. Further, when the control loop is used, the average rotary table speed becomes independent of pipe torque. The system has proved to be reliable under field operating conditions.

Introduction

In applying technology to a drilling operation, rotary speed is of prime importance. For example, the "d" exponent, formation drillability, roller bit bearing and tooth wear as well as many other drilling relationships are functions of rotary speed.l-3 To use rotary speed in any of these equations, it must be measurable and fairly constant over the time interval of interest. The conventional method of controlling rotary speed on a rig, with an independent and mechanically driven rotary table is through the use of a pneumatic regulator at the drawworks. The regulator supplies air pressure to a diaphragm which mechanically positions the engine throttle. This method does not provide a constant rotary speed. Variations in rotary torque present a constantly changing load to the engine. Consequently, if the throttle is held constant, the angular speed of the rotary table will vary considerably. This effect is illustrated in Fig. 1, which is an actual recording of torque and rotary speed on a rig where the rotary speed was controlled in the manner described above. Note that the average value of rotary speed varied inversely with torque until the driller finally changed the throttle setting to bring the rotary speed back to its initial value. In order to keep rotary speed constant, the throttle would have to be continuously repositioned to compensate for the load changes. An automatic closed-loop control system can perform this operation.
Rice yield benefits from historical climate warming to be negated by extreme heat in Northeast China
Authors: Dong Xin , Zhang Tianyi , Yang Xiaoguang , Li Tao , Li Xichen
Published: May 2022

Rice is currently benefiting from climate warming in Northeast China, but whether such positive effects will continue in the future remains unknown. Using county-level rice yield and climate data in Northeast China from 1980-2015, we examined the impacts of individual and combined climate variables on rice yields, estimated climate-induced yield changes, and quantified the associated contributions of these climate variables. The results suggest that climate change has caused a 10.1% yield increase in Northeast China since 1980. The main reasons are the reduced chilling damage (+5.4%) and warming below the optimum growth temperature (+4.6%). The influence of warming beyond the optimum growth temperature (i.e., high-temperature extremes) is quite limited (-0.054%) at present. However, with continuous warming, the harmful impact of such high-temperature extremes will outweigh other positive climate effects when the temperature increases by 3.36°C. Therefore, high-temperature extremes cannot be ignored despite their influence on rice yield being quite limited in Northeast China. Climate change mitigation and heat tolerance breeding are thus necessary for rice production in Northeast China.
Results of a worldwide External Quality Assessment of cfDNA testing in Lung Cancer
Authors: Fairley Jennifer A. , Cheetham Melanie H. , Patton Simon J. , Rouleau Etienne , Denis Marc , Dequeker Elisabeth M.C , Schuuring Ed , Casteren Kaat Van , Fenizia Francesca , Normanno Nicola , Deans Zandra C.
Published: May 2022

BackgroundCirculating cell free DNA (cfDNA) testing of plasma for EGFR somatic variants in lung cancer patients is being widely implemented and with any new service, external quality assessment (EQA) is required to ensure patient safety. An international consortium, International Quality Network for Pathology (IQNPath), has delivered a second round of assessment to measure the accuracy of cfDNA testing for lung cancer and the interpretation of the results.Methods A collaboration of five EQA provider organisations, all members of IQNPath, have delivered the assessment during 2018-19 to a total of 264 laboratories from 45 countries. Bespoke plasma reference material containing a range of EGFR mutations at varying allelic frequencies were supplied to laboratories for testing and reporting according to routine procedures. The genotyping accuracy and clinical reporting was reviewed against standardised criteria and feedback was provided to participants.Results The overall genotyping error rate in the EQA was found to be 11.1%. Low allelic frequency samples were the most challenging and were not detected by some testing methods, resulting in critical genotyping errors. This was reflected in higher false negative rates for samples with variant allele frequencies (VAF) rates less than 1.5% comparted to higher frequencies. A sample with two different EGFR mutations gave inconsistent detection of both mutations. However for one sample, where two variants were present at a VAF of less than 1% then both mutations were correctly detected in 145/263 laboratories. Reports often did not address the risk that tumour DNA may have not been tested and limitations of the methodologies provided by participants were insufficient. This was reflected in the average interpretation score for the EQA being 1.49 out of a maximum of 2.Conclusions The variability in the standard of genotyping and reporting highlighted the need for EQA and educational guidance in this field to ensure the delivery of high-quality clinical services where testing of cfDNA is the only option for clinical management.
Evaluation of productive performance in synthetic maternal line (APRI rabbits) under Egyptian conditions.
Authors: EL-Deghadi Amira soliman
Published: May 2022

Synthetic lines have been developed in hot climate countries over the last few decades through selection for specific goals such as APRI rabbits, and depending on their specialisation, these lines perform better than the standard of the original breeds, and contemporary production tends to rely on them. The aim of the study was to identify and explain genetic parameters in synthetic maternal line (APRI rabbits) under Egyptian conditions. (DFREML) was used to assess data on body weights (BW) at 4, 8, and 12 weeks, also daily gains (DG) at 4-8, 8-12 and 4-12 weeks. Highest heritability (h2) estimate for BW was at 4 weeks (0.10), while the lowest estimate was at 12 weeks (0.03). The highest estimate (0.08) was for h2 of DG at 4-8 weeks, while the lowest estimate was for DG at 8-12 weeks (0.02). All genetic correlations (rg) between BW at different ages were moderate to high and positive; estimates of rg for DG ranged from low to high and were positive, with the exception of -0.84 between 4-8 and 8-12 weeks. BW and DG at different intervals had significance and the highest value in the first parity. BW and DG were significantly different in different seasons (P <0.05), with the highest value in the autumn. Significant differences in BW owing to litter size at birth (LSB) (P<0.05). Moreover, LSB had a significant impact on DG at 8-12 and 4-12 weeks, but not at 4-8 weeks.
Optimal Time to Attain a Targeted Profit Function Under Unitary Transformation
Authors: Dube Partha
Published: May 2022

The problem of fastest descent is solved by the calculus of variations which is a branch of mathematics dealing with the optimization problem of physical quantities. In this paper, profit maximization problems are judged by using this idea. In an economic system profit velocity and time are key factors to optimize policy. That is why we have investigated the path of the profit function and the minimum time to reach the final destination of a profit function by utilizing a unitary operator. Given two states, the starting profit function and the targeted profit function, there is a path which optimizes the economic policy in a least possible time among different paths. This investigation uses the unitary transformation, which transforms the starting profit function to the targeted profit function in the least possible time.JEL Classifications: C61; D21
De-industrialisation and poverty in Turkey
Authors: Bayar Ayşe Aylin , Günçavdı Öner , Levent Halul
Published: May 2022

De-industrialisation has emerged as a crucial problem in today's developing economies, and globalisation and rapid technological progress have widely been considered as its causes. However, de-industrialisation has also been going along with a change in political discourse in some countries like Turkey, and it appears to have led to a rise in economic populism. An increase in the shares of non-tradable economic activities in value-added and employment come forward as both an instrument of economic populism and the sign of de-industrialisation. Today's populist discourse is also accompanied by high economic growth led by high non-tradable economic activities and a fall in poverty. This paper examines an empirical link between the recent fall in Turkish poverty and the rise in non-tradable activities and income. De-industrialisation seems to become apparent after 2009, and non-tradable economic activities have overwhelmingly become the engine of economic growth after this year in Turkey. The result shows that non-tradable income distinctively has more reducing impacts on poverty than those of other tradable and agricultural income. This can be regarded as one of the reasons why the Turkish policymaker fulfilling populist discourse chooses non-tradable economic activities and encourage non-tradable income to rise on average more than others.JEL Code: E25, I32, O11, O14
Circuit encapsulation for efficient quantum computing based on controlled many-body dynamics
Authors: Ran Shi-Ju , Lu Ying , Zhou Peng-Fei , Fei Shao-Ming
Published: May 2022

Controlling the time evolution of quantum many-body systems is an important approach of implementing quantum computing. Different from the approaches by compiling the circuits into the product of multiple elementary gates, we here propose the quantum circuit encapsulation (QCE), where we encapsulate the target circuit into different parts, and optimize the magnetic fields to realize the unitary transformation of each part by the time evolution. The time-dependent magnetic fields are optimized by the automatic differentiation technique that originated from the field of machine learning. The QCE is demonstrated to possess well-controlled error and time cost, which avoids the error accumulations by aiming at finding the shortest path directly to the target unitary. We test four different encapsulation ways to realize the multi-qubit quantum Fourier transformations by controlling the time evolution of the quantum Ising chain. The scaling behaviors of the time costs and errors against the number of two-qubit controlled gates are demonstrated. The QCE provides an alternative compiling scheme that translates the circuits into a physically-executable form based on the quantum many-body dynamics, where the key issue becomes the encapsulation way to balance between the efficiency and flexibility.