bluuebunny/crossref_metadata_2025 huggingface dataset:
Knowledge structure and future research trends of body–mind exercise for mild cognitive impairment: a bibliometric analysis
Authors: Zhang Jing , Yang Zhen , Fan Huiying
Published: January 2024

Background

Mild cognitive impairment (MCI) is a common neurodegenerative disorder that poses a risk of progression to dementia. There is growing research interest in body–mind exercise (BME) for patients with MCI. While we have observed a rapid growth in interest in BME for MCI over the past 10 years, no bibliometric analysis has investigated the knowledge structure and research trends in this field. Consequently, the objective of this research is to conduct a bibliometric analysis of global publications of BME for MCI from 2013 to 2022.

Methods

A total of 242 publications in the field of BME for MCI were retrieved from the Web of Science Core Collection. Bibliometric analysis, including performance analysis, science mapping, and visualization, was performed using CiteSpace, VOSviewer, and Microsoft Excel.

Results

Publications and citations in the field of BME for MCI have shown a rapidly increasing trend over the last decade. Geriatrics & Gerontology, and Neurosciences were the most frequently involved research categories. China (78 documents) and the USA (75 documents) contributed to the largest number of publications and had the strongest international collaborative networks. Fujian University of Traditional Chinese Medicine contributed to the largest number of publications (12 documents), and Chen, L of this institution was the most prolific author (12 documents). Frontiers in Aging Neuroscience (16 documents), and JOURNAL OF ALZHEIMER’S DISEASE (12 documents) were the most prolific journals. Tai Chi and Baduanjin, as specific types of BME, were the hotspots of research in this field, while evidence synthesis and guidelines might be future research trends.

Conclusion

In the last decade, there has been a rapid growth in scientific activities in the field of BME for MCI. The results of this study provide researchers and other stakeholders with knowledge structure, hotspots, and future research trends in this field.
Unfavorable nutrient intakes in children up to school entry age: results from the nationwide German KiESEL study
Authors: Burgard Leonie , Jansen Sara , Spiegler Clarissa , Brettschneider Anna-Kristin , Straßburg Andrea , Alexy Ute , Storcksdieck genannt Bonsmann Stefan , Ensenauer Regina , Heuer Thorsten
Published: January 2024

Background

Nutrition in the first years of life is a cornerstone for child development and long-term health, yet there is a lack of current data on energy and nutrient intake among toddlers and preschoolers in Germany.

Objective

To analyze energy and nutrient intake in toddlers (1- to 2-year-olds) and preschoolers (3- to 5-year-olds) in Germany and compare the results with the Dietary Reference Values (DRVs) by the European Food Safety Authority.

Design

Dietary intake was assessed by weighed food record data (3 + 1 day) of 890 children from the representative cross-sectional Children’s Nutrition Survey to Record Food Consumption (KiESEL), carried out in 2014–2017 as a module of the German Health Interview and Examination Survey for Children and Adolescents Wave 2. For the calculation of energy and nutrient intake, the German Nutrient Database BLS 3.02, LEBTAB, and a supplement database were used.

Results

Median intakes of energy and most nutrients met or exceeded the DRVs in both toddlers and preschoolers. However, low intakes relative to DRVs were found for vitamin D (6–9% of DRV, including supplements) and iodine (57–65% of DRV). Age specific downward deviations were observed for iron intake in toddlers (75% of DRV) and for calcium intake in preschoolers (67–77% of DRV). In contrast, intakes were high for saturated fatty acids (SFA) (14–16 E%), mono-/disaccharides (60–87 g/day), and protein [2.1–2.6 g/(kg body weight*day)].

Conclusion

Nutrient imbalances in toddlers and preschoolers in Germany, which are partly age-related, give rise to concern. Research is needed to determine if routine vitamin D supplementation should be extended beyond infancy. Public health efforts to increase the rate of use of iodized salt and to reduce the intake of SFA and mono-/disaccharides in children’s diets are to be strengthened.
MR imaging-based risk stratification scoring system to predict clinical outcomes in carotid body tumors
Authors: Mahajan Abhishek , Shaikh Atif , Shukla Shreya , Vaish Richa , Agarwal Ujjwal , Smriti Vasundhara , Rastogi Shivam , Deokar Shonal , Suryavanshi Shubham , Chaturvedi Pankaj , Laskar Sarbani Ghosh , Prabhash Kumar , Patil Vijay , Noronha Vanita , Menon Nandini , Pai Prathamesh , Pantvaidya Gouri , Rane Swapnil Ulhas , Bal Munita , Mittal Neha , Patil Asawari , Dcruz Anil Keith
Published: January 2024

Objectives

This study aims to evaluate the role of pretherapy MRI in predicting outcomes in carotid body tumors and propose a grading system for high- and low-risk characteristics.

Materials and methods

A retrospective observational study of 44 patients with 51 lesions was carried out from year 2005 to 2020. MR images were reviewed for characteristics of carotid body tumor, and a score was given that was correlated with intra- and postoperative findings. The various other classifications and our proposed Mahajan classification were compared with Shamblin’s classification. The area under the curve and ROC curves were used to present the accuracy of different predictive models.

Results

Our scoring system allotted a score of 0 to 15 on the basis of MRI characteristics, with scores calculated for patients in our study ranging from 0 to 13. Lesions with scores of 0–6 were considered low risk (45%), and scores of 7–15 were regarded as high risk for surgery (55%). The Mahajan classification stages tumors into four grades: I (10%), II (20%), IIIa (8%), and IIIb (62%). The frequency of vascular injury was 50% in category I and 64% in category IIIb. The frequency of cranial nerve injury was 50%, 66%, and 27% in categories I, II, and IIIb.

Conclusion

The Mahajan classification of CBTs evaluates high-risk factors like the distance of the tumor from the skull base and the angle of contact with ICA, which form the major predictors of neurovascular damage and morbidity associated with its surgery. Though the Shamblin classification of CBT is the most widely accepted classification, our proposed Mahajan classification system provides an imaging-based alternative to prognosticate surgical candidates preoperatively.
Improving the identification of high-risk non-metastatic castration-resistant prostate cancer patients in clinical practice
Authors: Rosinha Alina , Rabaça Carlos , Calais Fernando , Pinto João Moreira , Barreira João Vasco , Fernandes Ricardo , Ramos Rodrigo , Fialho Ana Cristina , Palma dos Reis José
Published: January 2024

Non-metastatic castration-resistant prostate cancer (nmCRPC) represents a challenging disease state in prostate cancer care. nmCRPC patients with a high risk of progression to metastatic disease who are identified by a prostate-specific antigen doubling time (PSADT) ≤10 months are eligible for treatment with the novel androgen receptor inhibitors (ARIs), shown to delay disease progression and extend survival. However, nmCRPC is often unexploited in clinical practice due to a lack of standardization in the methodology and in the tools used for its identification. In this article, a group of Urology and Oncology specialists with acknowledged expertise in prostate cancer reviews the state of the art in the management of high-risk nmCRPC patients, identifies gaps and unmet needs, and proposes strategies to optimize the identification of this patient subgroup in the clinical practice and improve their health outcomes.
Neoadjuvant short-course radiotherapy or chemoradiation plus consolidative chemotherapy followed by radical operation for locally advanced rectal cancer
Authors: Lee Shing Fung , Yip Pui Lam , Wo Barry , Wong Natalie Sean-Man , Vellayappan Balamurugan A. , Mamon Harvey J. , Lee Francis Ann Shing
Published: January 2024

Introduction

Limited evidence compares short-course radiotherapy (SCRT) and long-course chemoradiotherapy (LCCRT), both of which are followed by consolidative chemotherapy before radical rectal surgery. We conducted a retrospective cohort study to assess treatment response, survival outcomes, and toxicity in patients with locally advanced rectal cancer.

Materials and methods

Patients (cT3–4 and/or N+) treated with SCRT or LCCRT, consolidative chemotherapy, or total mesorectal excision between 2013 and 2021 were identified. the cause-specific cumulative incidence of disease-related treatment failure, locoregional recurrence, distant metastases, and overall survival were evaluated using flexible parametric competing risk analysis and Kaplan–Meier methods, adjusted for treatment regimens and clinicopathological factors. A pathological complete response (pCR), tumor downstaging, and toxicity have been reported.

Results

Among the 144 patients, 115 (80%) underwent curative rectal surgery. The LCCRT and SCRT groups achieved pCR in 10 (18%) and seven (12%) patients, respectively (odds ratio, 1.68; 95% confidence interval [CI], 0.59–4.78). The adjusted cause-specific hazard ratio for disease-related treatment failure with LCCRT versus SCRT was 0.26 (95% CI, 0.08–0.87). Three-year cumulative probability of disease-related treatment failure was 10.0% and 25.6% for LCCRT and SCRT, respectively. No significant differences in T-downstaging, N-downstaging, significant pathologic downstaging (ypT0-2N0), locoregional failure, distant metastasis, or overall survival were found. Late rectal toxicity occurred in 10 (15%) LCCRT and two (3%) SCRT patients, respectively.

Conclusion

LCCRT with consolidative chemotherapy demonstrated improved disease-related treatment failure compared with SCRT, despite higher late rectal toxicity. Further research is needed to assess the long-term oncologic outcomes and toxicity.
Case report: Diagnosis of NUT carcinoma of hepatic origin by next-generation sequencing
Authors: Ardalan Bach , Azqueta Jose , Luo Jia , French Christopher
Published: January 2024

NUT carcinoma is a rare subcategory of squamous cell carcinoma. The latter is primarily characterized by the fusion of the coding sequence NUTM1 on chromosome 15q14 with BRD4 or BRD3, both of which are acetyl-histone binding bromodomains. This tumor is often misdiagnosed due to its rarity and its histological similarity with other squamous cell carcinomas. It typically presents as a poorly differentiated squamous cell carcinoma in the head, neck, and mediastinal region, and has no distinct clinical characteristics that set it apart from other malignancies. Although uncommon, other NUT carcinomas have been reported in the literature outside of the midline region. Through next-generation sequencing, we were able to correctly diagnose our patient with the first-documented case of NUT carcinoma of hepatic-only origin.
Successful management of bilateral orbital metastases from invasive lobular breast cancer with abemaciclib and letrozole: a case report and literature review
Authors: Rodrigues Alves Nuno , Duarte Ana Filipa , Ribeiro David Fernandes , Silva Rita Sousa , Carvalho Bruno Almeida , Alpuim Costa Diogo
Published: January 2024

Breast cancer is a significant global health concern, contributing to substantial morbidity and mortality among women. Hormone receptor-positive (HR+)/HER2-negative (HER2-) breast cancer constitutes a considerable proportion of cases, and significant advancements have been made in its management. CDK4/6 inhibitors (CDK4/6is) are a new targeted therapy that has demonstrated efficacy in adjuvant, advanced and metastatic settings. The propensity of lobular breast carcinomas for estrogen-rich sites, such as periocular tissues and orbital fat, may explain their tendency for orbital metastases. Current treatment strategies for these cases are predominantly palliative, and the prognosis remains poor. This article presents a unique case of a 51-year-old female with progressive right periorbital edema, pain, and limited ocular motility. An imaging work-up showed bilateral intra and extraconal orbital infiltration, which was biopsied. The histopathologic analysis disclosed mild chronic inflammatory infiltrate with thickened fibrous tissue and moderately differentiated lobular carcinoma cells, positive for GATA3 and CK7 markers, with 100% of tumor nuclei expressing estrogen receptors (ER+). A systemic evaluation showed a multicentric nodular formation in both breasts. Further diagnostic assessments unveiled an HR+/HER2- bilateral lobular breast carcinoma with synchronous bilateral orbital metastases. Systemic treatment was initiated with abemaciclib 150mg twice daily and letrozole 2.5mg once a day. However, this regimen was interrupted due to toxicity. After two weeks, treatment was resumed with a reduced abemaciclib dose (100mg twice daily) alongside letrozole, with a reasonable tolerance. Nearly two years after the initial diagnosis of inoperable metastatic cancer, the patient remains on the same systemic treatment regimen with no signs of invasive disease. This case report is the first of a patient presenting with bilateral orbital metastases from bilateral lobular breast cancer, showing an impressive and sustained response to a first-line treatment regimen combining abemaciclib and letrozole. A literature review on bilateral orbital metastases from breast cancer is also presented.
Immune checkpoint blockade in hematological malignancies: current state and future potential
Authors: Pophali Prateek , Varela Juan Carlos , Rosenblatt Jacalyn
Published: January 2024

Malignant cells are known to evade immune surveillance by engaging immune checkpoints which are negative regulators of the immune system. By restoring the T-lymphocyte mediated anti-tumor effect, immune checkpoint inhibitors (ICI) have revolutionized the treatment of solid tumors but have met rather modest success in hematological malignancies. Currently, the only FDA approved indications for ICI therapy are in classic hodgkin lymphoma and primary mediastinal B cell lymphoma. Multiple clinical trials have assessed ICI therapy alone and in combination with standard of care treatments in other lymphomas, plasma cell neoplasms and myeloid neoplasms but were noted to have limited efficacy. These trials mostly focused on PD-1/PDL-1 and CTLA-4 inhibitors. Recently, there has been an effort to target other T-lymphocyte checkpoints like LAG-3, TIM-3, TIGIT along with improving strategies of PD-1/PDL-1 and CTLA-4 inhibition. Drugs targeting the macrophage checkpoint, CD47, are also being tested. Long term safety and efficacy data from these ongoing studies are eagerly awaited. In this comprehensive review, we discuss the mechanism of immune checkpoint inhibitors, the key takeaways from the reported results of completed and ongoing studies of these therapies in the context of hematological malignancies.
Sequential autologous CAR-T and allogeneic CAR-T therapy successfully treats central nervous system involvement relapsed/refractory ALL: a case report and literature review
Authors: Liu Yifan , Li Yanfen , Yu Zhangyu , Wang Rongrong , Jing Yu
Published: January 2024

Background

The central nervous system (CNS) is the most common site of extramedullary invasion in acute lymphoblastic leukemia (ALL), and involvement of the CNS is often associated with relapse, refractory disease, and poor prognosis. Chimeric antigen receptor-T (CAR-T) cell therapy, a promising modality in cancer immunotherapy, has demonstrated significant advantages in the treatment of hematological malignancies. However, due to associated adverse reactions such as nervous system toxicity, the safety and efficacy of CAR-T cell therapy in treating CNSL remains controversial, with limited reports available.

Case report

Here, we present the case of a patient with confirmed B-ALL who experienced relapse in both bone marrow (BM) and cerebrospinal fluid (CSF) despite multiple cycles of chemotherapy and intrathecal injections. The infusion of autologous CD19 CAR-T cells resulted in complete remission (CR) in both BM and CSF for 40 days. However, the patient later experienced a relapse in the bone marrow. Subsequently, allogeneic CD19 CAR-T cells derived from her brother were infused, leading to another achievement of CR in BM. Significantly, only grade 1 cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) events were detected during the treatment period and showed improvement with symptomatic management. During subsequent follow-up, the patient achieved a disease-free survival of 5 months and was successfully bridged to hematopoietic stem cell transplantation.

Conclusion

Our study provides support for the argument that CNS involvement should not be deemed an absolute contraindication to CAR-T cell therapy. With the implementation of suitable management and treatment strategies, CAR-T therapy can proficiently target tumor cells within the CNS. This treatment option may be particularly beneficial for relapsed or refractory patients, as well as those with central nervous system involvement who have shown limited response to conventional therapies. Additionally, CAR-T cell therapy may serve as a valuable bridge to allogeneic hematopoietic stem cell transplantation (allo-HSCT) in these patients.
Novel sensor developments for photon science at the MPG semiconductor laboratory
Authors: Ninkovic J. , Bähr A. , Richter R. H. , Treis J.
Published: January 2024

The world of photon science experiences significant advancements since the advent of synchrotron light sources with unprecedented brilliance, intensity and pulse repetition rates, with large implications on the detectors used for instrumentation. Here, an overview about the work on this field carried out at the semiconductor laboratory of the Max-Planck-Society (MPG HLL) is given. Main challenges are high dynamic range to resolve faint features at the fringes of scatter images as well as structures in bright peaks, and high bandwidth to fully exploit the fast timing capability of the source. A newly developed device to improve the signal-to-noise-ratio (SNR) at high bandwidths is the so-called MARTHA (Monolithic Array of Reach-Through Avalanche Photodiodes) structure, which integrates an array of APDs on a monolithic substrate. The reach-through architecture assures near 100% fill factor and allows implementing a thin entrance window with optimized quantum efficiency for low energy X-rays. The structures operate in proportional mode with adjustable gain, and can serve as a drop-in replacement for PAD detectors in hybrid pixel systems. A more sophisticated solution for low to medium frame rate applications with high contrast requirement are pnCCDs with high dynamic range in the pixel area featuring DEPFET based readout nodes with non-linear amplification (NLA). The high dynamic range mode has been demonstrated for pnCCD devices with a pixel size down to 75 μm2. Framerates of up to 1 kHz are possible for a 1 Megapixel detector. Small size prototypes of these structures have recently been manufactured. Modified DEPFET structures with build-in non-linear amplification are also used to implement active pixel detectors optimized for high dynamic range. Successfully prototyped for the DSSC sensors (DEPFET Sensor with Signal Compression) at the XFEL, these structures are increasingly being used in applications requiring high contrast and intensity, e.g., TEM imaging. Charge handling capability and output characteristics can be tailored to the requirements, as well as pixel geometry and size. The large intrinsic gain of the DEPFET provides excellent SNR even at fast timing. Pixels can be read with a speed of 100 ns, the resulting frame rate depends on the degree of readout parallelization.
Effects of acute bouts of evening resistance or endurance exercises on sleep EEG and salivary cortisol
Authors: Perrier Joy , Langeard Antoine , Ouma Chandrou Koumar , Sesboüé Bruno , Clochon Patrice , Prevost Jean-Noël , Bertran Françoise , Davenne Damien , Bessot Nicolas
Published: January 2024

Introduction: Deleterious effects of exercise close to bedtime could be due to increased physiological arousal that can be detected during sleep using sleep spectral analysis. Resistance and endurance exercises have different effects on cortisol release that may lead them to impact sleep spectral signatures differently. The present study aimed to investigate the effects of two types of evening exercise on sleep architecture, sleep spectral parameters and salivary cortisol.

Methods: Young healthy participants came to our laboratory to undergo 3 counterbalanced pre-sleep conditions that started 1 h before bedtime (a resistance and an endurance exercise conditions of 30 min duration, identical in terms of workload; and a control condition) followed by polysomnographic recordings. Results were compared between the three conditions for 16 participants.

Results: Sleep efficiency was lower after both endurance and resistance exercise than after the control condition. Total sleep time was lower after endurance exercise compared to the control condition. Sleep spectral analyses showed that both endurance and resistance exercises led to greater alpha power during N1 sleep stage and greater theta power during N2 sleep stage compared to the control condition. The endurance exercise led to greater beta power during N2 sleep stage, greater alpha power during REM sleep, and higher cortisol levels compared to the control condition (trend), and compared to the resistance exercise condition (significant). The resistance exercise led to lower beta power during N2 sleep stage than the control condition and lower cortisol levels than the endurance exercise condition.

Discussion: This study underlines significant modifications of sleep quality and quantity after both moderate evening endurance and resistance exercises. Still, these effects cannot be considered as deleterious. In contrast to the resistance exercise, endurance exercise led to an increase in sleep EEG activity associated with hyperarousal during sleep and higher cortisol levels, suggesting an hyperarousal effect of endurance exercise performed in the evening. These results align with previous warning about the arousal effects of evening exercise but do not support the notion of deleterious effects on sleep. While these results provide support for the physiological effects of evening exercises on sleep, replication with larger sample size is needed.
SGR-YOLO: a method for detecting seed germination rate in wild rice
Authors: Yao Qiong , Zheng Xiaoming , Zhou Guomin , Zhang Jianhua
Published: January 2024

Seed germination rate is one of the important indicators in measuring seed quality and seed germination ability, and it is also an important basis for evaluating the growth potential and planting effect of seeds. In order to detect seed germination rates more efficiently and achieve automated detection, this study focuses on wild rice as the research subject. A novel method for detecting wild rice germination rates is introduced, leveraging the SGR-YOLO model through deep learning techniques. The SGR-YOLO model incorporates the convolutional block attention module (efficient channel attention (ECA)) in the Backbone, adopts the structure of bi-directional feature pyramid network (BiFPN) in the Neck part, adopts the generalized intersection over union (GIOU) function as the loss function in the Prediction part, and adopts the GIOU function as the loss function by setting the weighting coefficient to accelerate the detection of the seed germination rate. In the Prediction part, the GIOU function is used as the loss function to accelerate the learning of high-confidence targets by setting the weight coefficients to further improve the detection accuracy of seed germination rate. The results showed that the accuracy of the SGR-YOLO model for wild rice seed germination discrimination was 94% for the hydroponic box and 98.2% for the Petri dish. The errors of germination potential, germination index, and average germination days detected by SGR-YOLO using the manual statistics were 0.4%, 2.2, and 0.9 days, respectively, in the hydroponic box and 0.5%, 0.5, and 0.24 days, respectively, in the Petri dish. The above results showed that the SGR-YOLO model can realize the rapid detection of germination rate, germination potential, germination index, and average germination days of wild rice seeds, which can provide a reference for the rapid detection of crop seed germination rate.
Differential distribution shifts in two subregions of East Asian subtropical evergreen broadleaved forests—a case of Magnoliaceae
Authors: Wu Hai-Yang , Liu Yue-Han , He Qiu-Xiang , Ye Jun-Wei , Tian Bin
Published: January 2024

Aim

East Asian subtropical evergreen broad-leaved forests (EBLFs) are composed of western and eastern subregions with different topographical and environmental conditions. The distribution shifts over time of plants in the two subregions are predicted to be different, but the difference has seldom been investigated.

Methods

Potential distributions of 53 Magnoliaceae species (22 in the western and 31 in the eastern subregion) during the last glacial maximum (LGM), present, and the 2070s were predicted using MaxEnt based on 58 environmental variables. The changes in the distribution range size and centroid over time were analyzed. Species-level potential habitats were overlaid to uncover species diversity distribution, and the distributions over time were overlaid to discover long-term refugia.

Results

At present, the potential distributions are significantly larger than those shown by the occurrence points. During the LGM, 20/22 species in the western subregion experienced increases in range size through downwards and southward migrations, while decreases in range size in the eastern subregion (27/31 species) were accompanied by northward and eastward migrations. In the future, range size declines and northward shifts will both be found; northwestward shifts will exist in most (20/22 species) species in the western subregion, while both northwest- and northeastward shifts will occur in the eastern subregion. The diversity hotspots experienced a slight southward shift in the past and upwards to the mountain region in the future in the western subregion; in the eastern subregion, shrinks occurred in eastern China in the past and shrinks were shown in all regions in the future. Long-term refugia-preserving diversity was found in the mountains across the entire EBLFs region.

Main conclusions

Significant differences in distribution shifts from past to present and similar distribution shifts from present to future are revealed in the two subregions. Species diversity in both subregions experienced no significant shifts from past to future, and Magnoliaceae plants could be preserved in mountainous regions throughout the EBLFs.
Determination of soluble solids content of multiple varieties of tomatoes by full transmission visible-near infrared spectroscopy
Authors: Li Sheng , Li Jiangbo , Wang Qingyan , Shi Ruiyao , Yang Xuhai , Zhang Qian
Published: January 2024

Introduction

Soluble solids content (SSC) is a pivotal parameter for assessing tomato quality. Traditional measurement methods are both destructive and time-consuming.

Methods

To enhance accuracy and efficiency in SSC assessment, this study employs full transmission visible and near-infrared (Vis-NIR) spectroscopy and multi-point spectral data collection techniques to quantitatively analyze SSC in two tomato varieties (‘Provence’ and ‘Jingcai No.8’ tomatoes). Preprocessing of the multi-point spectra is carried out using a weighted averaging approach, aimed at noise reduction, signal-to-noise ratio improvement, and overall data quality enhancement. Taking into account the potential influence of various detection orientations and preprocessing methods on model outcomes, we investigate the combination of partial least squares regression (PLSR) with two orientations (O1 and O2) and two preprocessing techniques (Savitzky-Golay smoothing (SG) and Standard Normal Variate transformation (SNV)) in the development of SSC prediction models.

Results

The model achieved the best results in the O2 orientation and SNV pretreatment as follows: ‘Provence’ tomato (Rp = 0.81, RMSEP = 0.69°Brix) and ‘Jingcai No.8’ tomatoes (Rp = 0.84, RMSEP = 0.64°Brix). To further optimize the model, characteristic wavelength selection is introduced through Least Angle Regression (LARS) with L1 and L2 regularization. Notably, when λ=0.004, LARS-L1 produces superior results (‘Provence’ tomato: Rp = 0.95, RMSEP = 0.35°Brix; ‘Jingcai No.8’ tomato: Rp = 0.96, RMSEP = 0.33°Brix).

Discussion

This study underscores the effectiveness of full transmission Vis-NIR spectroscopy in predicting SSC in different tomato varieties, offering a viable method for accurate and swift SSC assessment in tomatoes.
Psychometric properties of the Adolescent Motor Competence Questionnaire for Norwegian adolescents
Authors: Lorås Håvard , Haga Monika , Hagen Ruben Vist , Bjerke Øyvind , Timler Amanda , Sando Ole Johan
Published: January 2024

The objective of this study was to examine the psychometric properties of the Adolescent Motor Competence Questionnaire (AMCQ) for Norwegian adolescents. To this end, a sample of 349 Norwegian-speaking adolescents (13–16 years old) were recruited and completed the AMCQ. Initial results showed that confirmatory factor analysis (CFA) did not indicate statistical support for previous statistical models reported in the literature. Further analysis indicated factorial validity for a novel three-factor model identified through exploratory factor analysis, encompassing measures of fine motor skill (α = 0.65), gross motor skill (α = 0.74), and activities of daily living (ADL; α = 0.79) with acceptable internal consistency coefficients. Subsequent analysis indicated indices of measurement invariance in the study sample, as males rated their competence higher compared to females in 19 of the 27 items, and better model fit was obtained for the female adolescents. Strong invariance was tenable, and no factor mean differences were found across older and younger adolescents or across BMI scores. Overall results thus suggested that the AMCQ has acceptable psychometric properties and can be confidently used in further work with perceived motor competence in Norwegian 13–16 years-old adolescents.
Optimizing performance and mood state in competitive swimmers through tapering strategies
Authors: Aouani Hajer , Amara Sofiene , Rebai Haithem , Barbosa Tiago M. , van den Tillaar Roland
Published: January 2024

Tapering is a concept that is of great importance in relation to performance, due of its great effect on the psychological and physical condition of the swimmer. Therefore, the present study aims to investigate the effect of two-week of tapering characterized by a progressive training volume reduction on mood state and swimming performance in competitive swimmers. Twenty-four competitive male swimmers were randomly assigned into two groups. Experimental group (age = 16.9 ± 0.5 years) and control group (16.1 ± 0.4 years). The mood subscales (tension, depression, anger, fatigue, confusion and vigor), total mood disturbance and swimming performance (50-m front crawl) were measured in pre and posttest. Our findings revealed a significant improvement in mood subscales (20.8 to 47.8%), total mood disturbance (14.4%) and in swimming performance (3.5%) after 2 weeks of tapering training. A significant correlation was observed between the total mood disturbance and the 50 m front crawl (r = −0.63) only in the experimental group. It was concluded that a progressive reduction in training volume with a maintain of intensity could improve mood state and swimming performance. In addition, a change in total mood disturbance could affect swimming performance. Swimming coaches are advised to include tapering period according to the standards we mentioned earlier before competitive swimming to improve mental state, which helps the swimmers to overcome the negative influences of overtraining and therefore they can promote sprint-swimming performance.
What distinguishes emotion-label words from emotion-laden words? The characterization of affective meaning from a multi-componential conception of emotions
Authors: Betancourt Ángel-Armando , Guasch Marc , Ferré Pilar
Published: January 2024

Past research that distinguishes between affective and neutral words has predominantly relied on two-dimensional models of emotion focused on valence and arousal. However, these two dimensions cannot differentiate between emotion-label words (e.g., fear) and emotion-laden words (e.g., death). In the current study, we aimed to determine the unique affective characteristics that differentiate emotion-label, emotion-laden, and neutral words. Therefore, apart from valence and arousal, we considered different affective features of multi-componential models of emotion: action, assessment, expression, feeling, and interoception. The study materials included 800 Spanish words (104 emotion-label words, 340 emotion-laden words, and 356 neutral words). To examine the differences between each word type, we carried out a Principal Component Analysis and a Random Forest Classifier technique. Our results indicate that these words are characterized more precisely when the two-dimensional approach is combined with multi-componential models. Specifically, our analyses revealed that feeling, interoception and valence are key features in accurately differentiating between emotion-label, emotion-laden, and neutral words.
The psychological impact of the COVID-19 pandemic on physicians in Puerto Rico: a cross-sectional study after the second wave in 2021
Authors: Sanchez-Plazas Liza C. , García-De Jesus Ricardo , Martinez-Gonzalez Karen G. , Amaya-Ardila Claudia P. , Almodóvar-Rivera Israel A.
Published: January 2024

Introduction

Health care providers faced a challenge with the emergence of COVID-19 and its rapid spread. Early studies measuring the psychological impact of COVID-19 on the general population found high levels of anxiety and sleep disorders. The primary goal of this project was to assess the psychological impact of COVID-19 on physicians in Puerto Rico.

Materials and methods

A cross-sectional study of physicians in Puerto Rico was conducted anonymously and electronically from February 2021 through April 2021. The electronic survey included socio-demographic data and 4 self-administered assessment tools (Generalized Anxiety Disorder-7, Perceived Stress Scale-10, Pittsburgh Sleep Quality Index and COVID-19 Organizational Support) for anxiety, perceived stress, sleep disturbances, and organizational support during the COVID-19 pandemic.

Results

A total of 145 physicians completed the survey, with a female predominance of 53.5% and a majority practicing in the San Juan metropolitan area (50.3%). Mild anxiety symptoms were reported in 26.9% of physicians, and 33.8% had moderate to severe anxiety symptoms. Moderate to high perceived stress was found in 69.9% of participants, and women reported statistically significantly higher levels of anxiety symptoms (8.84 ± 5.99; p = 0.037) and stress (19.0 ± 6.94, p = 0.001). The Pittsburgh Sleep Quality Index reported 67.9% of physicians with global scores associated with poor sleep quality. Assessment of perceived organizational support found a high perception of work support (65.7%) but low perception of personal support (43.4%) and risk support (30.3%). A correlation analysis found a negative correlation for work and personal support, but a positive correlation for risk support, all statistically significant.

Conclusion

COVID-19 had a lasting psychological impact in health care providers in Puerto Rico a year after the beginning of the pandemic. Our data supports the importance of organizational support and its correlation with the development of anxiety. It is thus essential to develop strategies to identify individuals at risk of experiencing psychological disturbances and to provide effective support for medical professionals during medical emergencies for their well-being and optimal delivery of patient care.
Regional decreases of cortical thickness in major depressive disorder and their correlation with illness duration: a case-control study
Authors: Wang Fukun , Hou Xiaofang , Guo Xiao , Zang Chen , Wu Gang , Zhao Jingjing
Published: January 2024

Background

Alterations in brain structure and function in major depressive disorder (MDD) have been identified in a number of studies, but findings regarding cortical thickness were various and inconsistent. Our current study aims to explore the differences in cortical thickness between individuals with MDD and healthy controls (HC) in a Chinese population.

Methods

We investigated T1-weighted brain magnetic resonance imaging data from 61 participants (31 MDD and 30 HC). The cortical thickness between the two groups and analyzed correlations between cortical thickness and demographic variables in the MDD group for regions with significant between-group differences were conducted.

Results

Compared with the HC group, patients with MDD had significantly decreased cortical thickness, in left pars triangularis, left pars orbitalis, left rostral middle frontal gyrus, left supramarginal gyrus, right parahippocampal gyrus, right lingual gyrus, right fusiform and right inferior parietal gyrus. The cortical thickness of left rostral middle frontal gyrus was negatively correlated (r = −0.47, p = 0.028) with the illness duration in patients with MDD.

Conclusion

Our study distinguished that cortical thickness decreases in numerous brain regions both in the left and right hemisphere in individuals with MDD, and the negative correlation between the cortical thickness of left rostral middle frontal gyrus illness duration. Our current findings are valuable in providing neural markers to identify MDD and understanding the potential pathophysiology of mood disorders.
Development of a method and an assessment construct for person-centered translation of dementia public stigma scales
Authors: Lu Junfeng , Shan Yi , Ji Meng , Low Lee-Fay , Kim Sarang , Barcenilla-Wong Annica , Shen Sam , Chu Weiwei
Published: January 2024

Background

With the number of people with dementia dramatically increasing over time and dementia becoming a major health concern worldwide, scales have been developed to assess the stigma socially attached to this neurodegenerative disorder. There are, however, almost no available methods and assessment constructs for person-centered translation of dementia public stigma scales.

Objective

To develop such a method and such an assessment construct by translating the Dementia Public Stigma Scale (DPSS) into standard written Chinese.

Methods

We translated the DPSS following three major steps: (1) literal translation and mistranslation identification; (2) panel discussions of items with problematic translations; and (3) the final checking of the translated scale. Informed by the translation and adaptation process, we then developed a method for person-centered translation of dementia public stigma scales. Based on this method and our panel discussions, we finally proposed a tripartite assessment construct for quality evaluation of the translation of dementia public stigma scales.

Results

Forward and backward translation did not work sufficiently in dementia public stigma scale translation. Mistranslations were induced by three major causes, including confusion caused by multiple Chinese meanings of the immediate Chinese direct translation, the lack of immediate Chinese direct translation because of varying positive/negative emotions attached to multiple translations, and the lack of culture-specific idioms in Chinese. Based on these factors, we proposed a tripartite dementia translation assessment construct. Following this assessment tool, we determined the best Chinese version that could further be tested for its psychometric properties among the public.

Conclusion

A method and an assessment construct for person-centered translation of dementia public stigma scales were developed. Such a method and such an assessment construct could be followed in the translation of dementia public stigma scales and the translation evaluation of such scales.
Causal association of leisure sedentary behavior and cervical spondylosis, sciatica, intervertebral disk disorders, and low back pain: a Mendelian randomization study
Authors: Qiu Youjia , Wei Xingzhou , Tao Yuchen , Song Bingyi , Wang Menghan , Yin Ziqian , Xie Minjia , Duan Aojie , Chen Zhouqing , Wang Zhong
Published: January 2024

Background

Some studies suggest sedentary behavior is a risk factor for musculoskeletal disorders. This study aimed to investigate the potential causal association between leisure sedentary behavior (LSB) (including television (TV) viewing, computer use, and driving) and the incidence of sciatica, intervertebral disk degeneration (IVDD), low back pain (LBP), and cervical spondylosis (CS).

Methods

We obtained the data of LSB, CS, IVDD, LBP, sciatica and proposed mediators from the gene-wide association studies (GWAS). The causal effects were examined by Inverse Variance Weighted (IVW) test, MR-Egger, weighted median, weighted mode and simple mode. And sensitivity analysis was performed using MR-Pleiotropy Residual Sum and Outlier (MR-PRESSO) and MR-Egger intercept test. Multivariable MR (MVMR) was conducted to investigate the independent factor of other LSB; while two-step MR analysis was used to explore the potential mediators including Body mass index (BMI), smoking initiation, type 2 diabetes mellitus (T2DM), major depressive disorder (MDD), schizophrenia, bipolar disorder between the causal association of LSB and these diseases based on previous studies.

Results

Genetically associated TV viewing was positively associated with the risk of CS (OR = 1.61, 95%CI = 1.25 to 2.07, p = 0.002), IVDD (OR = 2.10, 95%CI = 1.77 to 2.48, p = 3.79 × 10−18), LBP (OR = 1.84, 95%CI = 1.53 to 2.21, p = 1.04 × 10−10) and sciatica (OR = 1.82, 95% CI = 1.45 to 2.27, p = 1.42 × 10−7). While computer use was associated with a reduced risk of IVDD (OR = 0.66, 95%CI = 0.55 to 0.79, p = 8.06 × 10−6), LBP (OR = 0.49, 95%CI = 0.40 to 0.59, p = 2.68 × 10−13) and sciatica (OR = 0.58, 95%CI = 0.46 to 0.75, p = 1.98 × 10−5). Sensitivity analysis validated the robustness of MR outcomes. MVMR analysis showed that the causal effect of TV viewing on IVDD (OR = 1.59, 95%CI = 1.13 to 2.25, p = 0.008), LBP (OR = 2.15, 95%CI = 1.50 to 3.08, p = 3.38 × 10−5), and sciatica (OR = 1.61, 95%CI = 1.03 to 2.52, p = 0.037) was independent of other LSB. Furthermore, two-step MR analysis indicated that BMI, smoking initiation, T2DM may mediate the causal effect of TV viewing on these diseases.

Conclusion

This study provides empirical evidence supporting a positive causal association between TV viewing and sciatica, IVDD and LBP, which were potentially mediated by BMI, smoking initiation and T2DM.
Association between type 2 diabetes mellitus and body composition based on MRI fat fraction mapping
Authors: An Qi , Zhang Qin-He , Wang Yue , Zhang Han-Yue , Liu Yu-Hui , Zhang Zi-Ting , Zhang Mei-Ling , Lin Liang-Jie , He Hui , Yang Yi-Fan , Sun Peng , Zhou Zhen-Yu , Song Qing-Wei , Liu Ai-Lian
Published: January 2024

Purpose

To explore the association between type 2 diabetes mellitus (T2DM) and body composition based on magnetic resonance fat fraction (FF) mapping.

Methods

A total of 341 subjects, who underwent abdominal MRI examination with FF mapping were enrolled in this study, including 68 T2DM patients and 273 non-T2DM patients. The FFs and areas of visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) and abdominal muscle (AM) were measured at the level of the L1-L2 vertebral. The FF of bone marrow adipose tissue (BMAT) was determined by the averaged FF values measured at the level of T12 and L1 vertebral, respectively. The whole hepatic fat fraction (HFF) and pancreatic fat fraction (PFF) were measured based on 3D semi-automatic segmentation on the FF mapping. All data were analyzed by GraphPad Prism and MedCalc.

Results

VAT area, VAT FF, HFF, PFF of T2DM group were higher than those of non-T2DM group after adjusting for age and sex (P < 0.05). However, there was no differences in SAT area, SAT FF, BMAT FF, AM area and AM FF between the two groups (P > 0.05). VAT area and PFF were independent risk factors of T2DM (all P < 0.05). The area under the curve (AUC) of the receiver operating characteristic (ROC) for VAT area and PFF in differentiating between T2DM and non-T2DM were 0.685 and 0.787, respectively, and the AUC of PFF was higher than VAT area (P < 0.05). Additionally, in seemingly healthy individuals, the SAT area, VAT area, and AM area were found to be significantly associated with being overweight and/or obese (BMI ≥ 25) (all P < 0.05).

Conclusions

In this study, it was found that there were significant associations between T2DM and VAT area, VAT FF, HFF and PFF. In addition, VAT area and PFF were the independent risk factors of T2DM. Especially, PFF showed a high diagnostic performance in discrimination between T2DM and non-T2DM. These findings may highlight the crucial role of PFF in the pathophysiology of T2DM, and it might be served as a potential imaging biomarker of the prevention and treatment of T2DM. Additionally, in individuals without diabetes, focusing on SAT area, VAT area and AM area may help identify potential health risks and provide a basis for targeted weight management and prevention measures.
“You turn the tap on, the water's there, and you just think everything's fine”: a mixed methods approach to understanding public perceptions of groundwater management in Baton Rouge, Louisiana, USA
Authors: Hemmerling Scott A. , Haertling Allison , Shao Wanyun , Di Leonardo Diana , Grismore Audrey , Dausman Alyssa
Published: January 2024

In Louisiana's Capital Area Groundwater Conservation District (CAGWCD), extensive groundwater withdrawals from the Southern Hills Aquifer System have begun to accelerate the infiltration of saltwater into the aquifer's freshwater sands. This accelerated saltwater intrusion has the potential to reduce the amount of groundwater available for public consumption and other industrial and agricultural uses throughout the region. In response to this threat, the Capital Area Ground Water Conservation Commission has begun development of a long-term strategic plan to achieve and maintain sustainable and resilient groundwater withdrawals from the aquifer system. The development of the strategic plan includes an assessment of public attitudes regarding groundwater and groundwater management in the CAGWCD. This paper presents the results of mixed methods public participatory research to evaluate current and historical views and attitudes around groundwater quality, quantity, and cost in the CAGWCD. The mixed methods approach used in this research employed a sequential explanatory design model consisting of two phases. The first phase involved the implementation of an internet-based survey, followed by a qualitative phase aimed at explaining and enhancing the quantitative results. The qualitative phase employed a combination of one-on-one interviews and focus groups. The research found that the primary governance obstacle that decision-makers may face in managing groundwater is a broad lack of public awareness of groundwater and groundwater issues in the CAGWCD. Despite the criticality of over-pumping and saltwater intrusion into the aquifer system, survey research and subsequent interviews and focus groups have shown that the public is largely unaware of these issues. This research also found a general lack of trust in both industry and government to manage groundwater issues and highlighted the need for groundwater management efforts to be led by unbiased, trusted institutions.