bluuebunny/crossref_metadata_2025 huggingface dataset:
The influence of fatty acid supply and aldehyde reductase deletion on cyanobacteria alkane generating pathway in Escherichia coli
Authors: Wang Juli , Yu Haiying , Song Xuejiao , Zhu Kun
Published: April 2018

Cyanobacteria alkane synthetic pathway has been heterologously constructed in many microbial hosts. It is by far the most studied and reliable alkane generating pathway. Aldehyde deformylating oxygenase (i.e., ADO, key enzyme in this pathway) obtained from different cyanobacteria species showed diverse catalytic abilities. This work indicated that single aldehyde reductase deletions were beneficial to Nostoc punctiforme ADO-depended alkane production in Escherichia coli even better than double deletions. Fatty acid metabolism regulator (FadR) overexpression and low temperature increased C18:1 fatty acid supply, and in turn stimulated C18:1-derived heptadecene production, suggesting that supplying ADO with preferred substrate was important to overall alkane yield improvement. Using combinational methods, 1 g/L alkane was obtained in fed-batch fermentation with heptadecene accounting for nearly 84% of total alkane.
A preliminary study of telemedicine for patients with hepatic glycogen storage disease and their healthcare providers: from bedside to home site monitoring
Authors: Hoogeveen Irene J. , Peeks Fabian , de Boer Foekje , Lubout Charlotte M. A. , de Koning Tom J. , te Boekhorst Sebastiaan , Zandvoort Robert‐Jan , Burghard Rob , van Spronsen Francjan J. , Derks Terry G. J.
Published: April 2018

Background

The purpose of this project was to develop a telemedicine platform that supports home site monitoring and integrates biochemical, physiological, and dietary parameters for individual patients with hepatic glycogen storage disease (GSD).

Methods and results

The GSD communication platform (GCP) was designed with input from software developers, GSD patients, researchers, and healthcare providers. In phase 1, prototyping and software design of the GCP has occurred. The GCP was composed of a GSD App for patients and a GSD clinical dashboard for healthcare providers. In phase 2, the GCP was tested by retrospective patient data entry. The following software functionalities were included (a) dietary registration and prescription module, (b) emergency protocol module, and (c) data import functions for continuous glucose monitor devices and activity wearables. In phase 3, the GSD App was implemented in a pilot study of eight patients with GSD Ia (n = 3), GSD IIIa (n = 1), and GSD IX (n = 4). Usability was measured by the system usability scale (SUS). The mean SUS score was 64/100 [range: 38–93].

Conclusions

This report describes the design, development, and validation process of a telemedicine platform for patients with hepatic GSD. The GCP can facilitate home site monitoring and data exchange between patients with hepatic GSD and healthcare providers under varying circumstances. In the future, the GCP may support cross‐border healthcare, second opinion processes and clinical trials, and could possibly also be adapted for other diseases for which a medical diet is the cornerstone.
Changes in the functional feeding groups of macrobenthic fauna during mangrove forest succession in Zhanjiang, China
Authors: Chen Quan , Zhao Qiao , Jian Shuguang , Chen Pimao
Published: April 2018

Understanding the relationships between mangrove forest succession and the functional diversity of mangrove fauna could facilitate the restoration of mangrove ecosystems, which have been severely damaged in recent decades. The current report describes changes in macrobenthic functional diversity in a mangrove chronosequence that included a primary community (unvegetated shoal), an early community (Avicennia marina), a middle community (Aegiceras corniculatum), and a late community (Bruguiera gymnorrhiza + Rhizophora stylosa) in Zhanjiang, China. Phytophages were the dominant macrobenthic functional feeding group regardless of mangrove succession stage, sampling season, or macrobenthic faunal parameter (species richness, abundance, and biomass). As mangrove succession progressed, the proportions of macrobenthic species richness, abundance, or biomass represented by omnivores significantly increased (except for biomass and in the late stage; ranged from 0.065 to 0.230 and 0.033 to 0.368, respectively in wet season, and 0.000 to 0.192 and 0.000 to 0.396, respectively in dry season), while the proportions significantly decreased for detritivores during the dry season (ranged from 0.156 to 0.056, 0.107 to 0.019, and 0.066 to 0.005, respectively). Non‐metric multi‐dimensional scaling and PERMANOVA also indicated that the structure of macrobenthic faunal functional feeding groups was significantly affected by mangrove succession. Further analyses indicated that the changes in the relative dominance among macrobenthic faunal functional feeding groups during mangrove succession were mainly associated with changes in plant density, coverage/canopy density, and total nitrogen content of sediment, i.e., they were mostly associated with changes in food sources. The results increase our understanding of the relationship between benthic functional diversity and mangrove succession and could help guide mangrove restoration in China and around the world.
Instantaneous foveated preview for progressive Monte Carlo rendering
Authors: Koskela Matias K. , Immonen Kalle V. , Viitanen Timo T. , Jääskeläinen Pekka O. , Multanen Joonas I. , Takala Jarmo H.
Published: April 2018

Progressive rendering, for example Monte Carlo rendering of 360° content for virtual reality headsets, is a time-consuming task. If the 3D artist notices an error while previewing the rendering, they must return to editing mode, make the required changes, and restart rendering. We propose the use of eye-tracking-based optimization to significantly speed up previewing of the artist’s points of interest. The speed of the preview is further improved by sampling with a distribution that closely follows the experimentally measured visual acuity of the human eye, unlike the piecewise linear models used in previous work. In a comprehensive user study, the perceived convergence of our proposed method was 10 times faster than that of a conventional preview, and often appeared to be instantaneous. In addition, the participants rated the method to have only marginally more artifacts in areas where it had to start rendering from scratch, compared to conventional rendering methods that had already generated image content in those areas.
Increased cumulative doses and appearance of hand‐foot skin reaction prolonged progression free survival in sorafenib‐treated advanced hepatocellular carcinoma patients
Authors: Chang Wen‐Tsan , Lu Sheng‐Nan , Rau Kung‐Ming , Huang Ching‐Shan , Lee King‐Teh
Published: April 2018

Sorafenib has been recommended as a new palliative therapy for advanced hepatocellular carcinoma (HCC). However, the clinical outcome of patients receiving sorafenib therapy varies. This study sought to identify which clinical method could be used to predict clinical outcome of sorafenib monotherapy in patients with advanced HCC. A total of 146 advanced HCC patients with Child‐Pugh A liver function were enrolled from June 2011 to September 2015. Sorafenib doses ranged from 200 mg once daily to 400 mg twice daily. Clinical and pathological parameters were collected. There was no predefined primary endpoint. Tumor response rate, adverse events, overall survival (OS), and progression‐free survival (PFS) were analyzed. The follow‐up period was 1718 days (median: 859 days). The median dosage of sorafenib was 562.35 mg. Forty patients (27.4%) had stable disease and 106 patients (72.6%) had progression disease. The OS was 432.21 ± 360.52 days (median: 329 days) and PFS was 167.05 ± 166.50 days (median: 102.5 days). No sorafenib toxic effect‐related mortality was encountered. The most common severe adverse events (≧grade 3) were hand‐foot skin reactions (HFSR) (16, 11.0%), diarrhea (7, 4.8%), and alopecia (1, 0.7%). The following patients had longer median PFS (mPFS): those receiving total dosage > 55000 mg (217 vs.63 days; HR = 0.20,95%CI = 0.11–0.38; p < 0.001), those receiving daily dosage <562 mg (140 vs.69 days; HR = 0.27, 95%CI = 0.17–0.46; p < 0.001), those with treatment durations > 112 days (231vs.64 days; HR = 0.37, 95%CI = 0.19–0.74; p < 0.001), and those with HFSR (105 vs.75 days; HR = 0.60,95% CI = 0.6–0.98; p = 0.04). In conclusion, increased cumulative doses of sorafenib as well as the appearance of HFSR were indicators of prolonged mPFS in sorafenib‐treated advanced HCC patients.
Referrals to the International Criminal Court Under Chapter VII of the United Nations Charter and the Immunity of Foreign State Officials
Authors: de Wet Erika
Published: April 2018

This contribution explores the implications of United Nations Security Council (UNSC) referrals under Chapter VII of the Charter of the United Nations to the International Criminal Court (ICC) for the immunity ratione personae of officials of states that are not party to the ICC Statute. While Article 13(b) of the ICC Statute allows the ICC to receive referrals of situations by the UNSC, disagreement remains among authors as to when such a referral removes the customary immunity attached to a head of state of a nonstate party to the ICC Statute. In particular, it remains disputed whether the broad obligation placed on Sudan by UNSC Resolution 1593 (2005) had the implicit effect of doing so. In referring the situation in Darfur (Sudan) to the ICC under Chapter VII of the UN Charter, the UNSC determined that “the government of Sudan, and all other parties to the conflict in Darfur, shall cooperate fully with and provide any necessary assistance to the Court and the prosecutor pursuant to this resolution.”
Immunity Ratione Materiae of State Officials from Foreign Criminal Jurisdiction: Where is the State Practice in Support of Exceptions?
Authors: Murphy Sean D.
Published: April 2018

In the summer of 2017, the UN International Law Commission adopted Draft Article 7 and an associated draft annex for its project on immunity of state officials from foreign criminal jurisdiction. The draft article identifies six “crimes under international law in respect of which immunity ratione materiae shall not apply”: genocide; crimes against humanity; war crimes; crime of apartheid; torture; and enforced disappearance. Given the divergences within the Commission when considering and adopting Draft Article 7 (as evidenced by the plenary debate in 2016 and 2017, the unusual recorded vote on whether to refer the matter to the Commission's drafting committee, and the Commentary), it is difficult to conclude that the Commission is expressing a view that Draft Article 7 reflects lex lata.
Methodological Flaws in the ILC's Study on Exceptions to Immunity Ratione Materiae of State Officials from Foreign Criminal Jurisdiction
Authors: Shen Qinmin
Published: April 2018

In July 2017, the UN International Law Commission (ILC) provisionally adopted Draft Article 7 on exceptions to immunity ratione materiae of state officials from foreign criminal jurisdiction, by a recorded vote of twenty-one votes in favor, eight votes against, and one abstention. In the view of the majority of ILC members, immunity ratione materiae does not apply to the six international crimes listed in the draft article—genocide, crimes against humanity, war crimes, apartheid, torture, and enforced disappearance—either because of a limitation or because of an exception. The unusual practice of adopting a draft article by recorded vote demonstrated the deep controversy among the ILC members themselves. After all, exceptions to official immunity lie at the core of the project of “Immunity of State Officials from Foreign Criminal Jurisdiction” that was started a decade ago by the ILC. This divisive Draft Article 7 naturally garnered criticism and equally deep controversy among states in discussions on the ILC's work report at UN General Assembly Sixth Committee in late October 2017.
Oscillatory flow regimes for a circular cylinder near a plane boundary
Authors: Xiong Chengwang , Cheng Liang , Tong Feifei , An Hongwei
Published: April 2018

Oscillatory flow around a circular cylinder close to a plane boundary is numerically investigated at low-to-intermediate Keulegan–Carpenter ($KC$) and Stokes numbers ($\unicode[STIX]{x1D6FD}$) for different gap-to-diameter ratios ($e/D$). A set of unique flow regimes is observed and classified based on the established nomenclature in the ($KC,\unicode[STIX]{x1D6FD}$)-space. It is found that the flow is not only influenced by $e/D$ but also by the ratio of the thickness of the Stokes boundary layer ($\unicode[STIX]{x1D6FF}$) to the gap size (e). At relatively large $\unicode[STIX]{x1D6FF}/e$ values, vortex shedding through the gap is suppressed and vortices are only shed from the top of the cylinder. At intermediate values of $\unicode[STIX]{x1D6FF}/e$, flow through the gap is enhanced, resulting in horizontal gap vortex shedding. As $\unicode[STIX]{x1D6FF}/e$ is further reduced below a critical value, the influence of $\unicode[STIX]{x1D6FF}/e$ becomes negligible and the flow is largely dependent on $e/D$. A hysteresis phenomenon is observed for the transitions in the flow regime. The physical mechanisms responsible for the hysteresis and the variation of marginal stability curves with $e/D$ are explored at $KC=6$ through specifically designed numerical simulations. The Stokes boundary layer over the plane boundary is found to be responsible for the relatively large hysteresis range over $0.25<e/D<1.0$. Three mechanisms have been identified to the change of the marginal stability curve over $e/D$, which are the blockage effect due to the geometry setting, the favourable pressure gradient over the gap and the location of the leading eigenmode relative to the cylinder.
Experiments on the breakup of drop-impact crowns by Marangoni holes
Authors: Aljedaani Abdulrahman B. , Wang Chunliang , Jetly Aditya , Thoroddsen S. T.
Published: April 2018

We investigate experimentally the breakup of the Edgerton crown due to Marangoni instability when a highly viscous drop impacts on a thin film of lower-viscosity liquid, which also has different surface tension than the drop liquid. The presence of this low-viscosity film modifies the boundary condition, giving effective slip to the drop along the solid substrate. This allows the high-viscosity drop to form a regular bowl-shaped crown, which rises vertically away from the solid and subsequently breaks up through the formation of a multitude of Marangoni holes. Previous experiments have proposed that the breakup of the crown results from a spray of fine droplets ejected from the thin low-viscosity film on the solid, e.g. Thoroddsen et al. (J. Fluid Mech., vol. 557, 2006, pp. 63–72). These droplets can hit the inner side of the crown forming spots with lower surface tension, which drives a thinning patch leading to the hole formation. We test the validity of this assumption with close-up imaging to identify individual spray droplets, to show how they hit the crown and their lower surface tension drive the hole formation. The experiments indicate that every Marangoni-driven patch/hole is promoted by the impact of such a microdroplet. Surprisingly, in experiments with pools of higher surface tension, we also see hole formation. Here the Marangoni stress changes direction and the hole formation looks qualitatively different, with holes and ruptures forming in a repeatable fashion at the centre of each spray droplet impact. Impacts onto films of the same liquid, or onto an immiscible liquid, do not in general form holes. We furthermore characterize the effects of drop viscosity and substrate-film thickness on the overall evolution of the crown. We also measure the three characteristic velocities associated with the hole formation: i.e. the Marangoni-driven growth of the thinning patches, the rupture speed of the resulting thin films inside these patches and finally the growth rate of the fully formed holes in the crown wall.
Passive scalar transport in rotating turbulent channel flow
Authors: Brethouwer Geert
Published: April 2018

Passive scalar transport in turbulent channel flow subject to spanwise system rotation is studied by direct numerical simulations. The Reynolds number $Re=U_{b}h/\unicode[STIX]{x1D708}$ is fixed at 20 000 and the rotation number $Ro=2\unicode[STIX]{x1D6FA}h/U_{b}$ is varied from 0 to 1.2, where $U_{b}$ is the bulk mean velocity, $h$ the half channel gap width and $\unicode[STIX]{x1D6FA}$ the rotation rate. The scalar is constant but different at the two walls, leading to steady scalar transport across the channel. The rotation causes an unstable channel side with relatively strong turbulence and turbulent scalar transport, and a stable channel side with relatively weak turbulence or laminar-like flow, weak turbulent scalar transport but large scalar fluctuations and steep mean scalar gradients. The distinct turbulent–laminar patterns observed at certain $Ro$ on the stable channel side induce similar patterns in the scalar field. The main conclusions of the study are that rotation reduces the similarity between the scalar and velocity field and that the Reynolds analogy for scalar-momentum transport does not hold for rotating turbulent channel flow. This is shown by a reduced correlation between velocity and scalar fluctuations, and a strongly reduced turbulent Prandtl number of less than 0.2 on the unstable channel side away from the wall at higher $Ro$. On the unstable channel side, scalar scales become larger than turbulence scales according to spectra and the turbulent scalar flux vector becomes more aligned with the mean scalar gradient owing to rotation. Budgets in the governing equations of the scalar energy and scalar fluxes are presented and discussed as well as other statistics relevant for turbulence modelling.
Bryozoan fauna of the Lake Valley Formation (Mississippian), New Mexico
Authors: Ernst Andrej , Krainer Karl , Lucas Spencer G.
Published: April 2018

Ten bryozoan species are described from the Andrecito and Tierra Blanca members of the Lake Valley Formation (Mississippian) of Sierra County, New Mexico, USA. One genus, with one species, is new—a cystoporate,Cystomeson sierraensisn. gen. n. sp. The bryozoans indicate quieter and deeper conditions in the Andrecito Member and more agitated and shallower conditions in the Tierra Blanca Member. The species identified in this study are endemic to North America, whereas at the generic level, the composition is rather cosmopolitan.

UUID:http://zoobank.org/fc354A60-1fbc-4e41-8b9b-bbfd65e59a71
Can Social Contact Reduce Prejudice and Discrimination? Evidence from a Field Experiment in Nigeria
Authors: SCACCO ALEXANDRA , WARREN SHANA S.
Published: April 2018

Can positive social contact between members of antagonistic groups reduce prejudice and discrimination? Despite extensive research on social contact, observational studies are difficult to interpret because prejudiced people may select out of contact with out-group members. We overcome this problem by conducting an education-based, randomized field experiment—the Urban Youth Vocational Training program (UYVT)—with 849 randomly sampled Christian and Muslim young men in riot-prone Kaduna, Nigeria. After sixteen weeks of positive intergroup social contact, we find no changes in prejudice, but heterogeneous-class subjects discriminate significantly less against out-group members than subjects in homogeneous classes. We trace this finding to increased discrimination by homogeneous-class subjects compared to non-UYVT study participants, and we highlight potentially negative consequences of in-group social contact. By focusing on skill-building instead of peace messaging, our intervention minimizes reporting bias and offers strong experimental evidence that intergroup social contact can alter behavior in constructive ways, even amid violent conflict.
An Equivariant Theory for the Bivariant Cuntz Semigroup
Authors: Tornetta Gabriele N.
Published: April 2018

We provide an equivariant extension of the bivariant Cuntz semigroup introduced in previous work for the case of compact group actions over C*-algebras. Its functoriality properties are explored, and some well-known classification results are retrieved. Connections with crossed products are investigated, and a concrete presentation of equivariant Cuntz homology is provided. The theory that is here developed can be used to define the equivariant Cuntz semigroup. We show that the object thus obtained coincides with the one recently proposed by Gardella [‘Regularity properties and Rokhlin dimension for compact group actions’, Houston J. Math.43(3) (2017), 861–889], and we complement their work by providing an open projection picture of it.
Non-destructive evaluation of Roman coin patinas from the 3rd and 4th century
Authors: Fawcett T. G. , Blanton J. R. , Blanton T. N. , Arias L. , Suscavage T.
Published: April 2018

Roman bronze coins from the 3rd and 4th century AD exhibit a wide variety of chemistries on their surfaces. This variation has been attributed to the variable methods used to produce the coins, a large number of mints producing bronze currency, and the periods of currency devaluation within the Roman Empire. Besides the base bronze metallurgy (Cu,Sn), Ag, Pb, and Zn were frequently used as coinage metals. Silver coatings were often applied to increase the apparent value of the coins. Over the centuries these surfaces corroded producing a range of patinas. Non-destructive X-ray diffraction and X-ray fluorescence methods were used to evaluate ancient bronze coins. These methods are limited by their half depth of penetration into the coins, so the focus was on the chemistry of the patina's and how they related to the current appearance. Several 3rd-century bronze coins exhibited a very dark patina that was often composed of CuCl, Cu2O (cuprite) and several forms of copper hydroxyl chloride, resulting from surface deterioration caused by corrosion and is often referred to as bronze disease. Coins of the latter 3rd century and 4th century often exhibit patinas that are corrosion products of lead, silver, and tin, as lead and tin preferentially oxidize relative to the bronze alloys.
Adapted CBT to Stabilize Sleep on Psychiatric Wards: a Transdiagnostic Treatment Approach
Authors: Sheaves Bryony , Isham Louise , Bradley Jonathan , Espie Colin , Barrera Alvaro , Waite Felicity , Harvey Allison G. , Attard Caroline , Freeman Daniel
Published: April 2018

Background: Almost all patients admitted at acute crisis to a psychiatric ward experience clinically significant symptoms of insomnia. Ward environments pose challenges to both sleep and the delivery of therapy. Despite this, there is no description of how to adapt cognitive behavioural therapy (CBT) for insomnia to overcome these challenges. Aims: (i) To describe the key insomnia presentations observed in the Oxford Ward Sleep Solution (OWLS) trial and (ii) outline key adaptations aimed to increase accessibility and hence effectiveness of CBT for insomnia for a ward setting. Methods: Trial therapists collaboratively agreed the key insomnia presentations and therapy adaptations based on their individual reflective logs used during the trial. Results: Three key insomnia presentations are outlined. These are used to illustrate the application of 10 CBT for insomnia therapy adaptations. These include use of sleep monitoring watches to engage patients in treatment, stabilizing circadian rhythms, reducing the impact of night-time observations and managing discharge as a sleep challenge. Conclusions: Whilst inpatient wards bring challenges for sleep and therapy delivery, creative adaptations can increase the accessibility of evidence based CBT for insomnia techniques. This therapy has proven popular with patients.
Twenty-one lessons learnt
Authors: Sergison Jonathan
Published: April 2018

A number of years ago, my practice Sergison Bates was invited to take part in a competition for a housing project in north London. At some point in the competitive interview, I stated that every project we undertake is unique in the set of interests it investigates, and could be understood as a form of research. I still believe that this is true, although I would be cautious about making the same comment again in such circumstances. We did not win the competition and found out later that a number of members of the members of the jury took issue with my statement. They misconstrued it, thinking that what we had in mind was some form of speculative enterprise with implicit risks and an uncertain outcome, which they would be funding. I now understand the difficulty the client had. Naturally, they wanted to be assured that we had the experience and competence to deliver a building that would serve their needs and be fit for purpose.

When we set up in practice – at about the same time as arq was launched – Stephen Bates and I had learnt some things about building from working for a number of established architects in practice. When we formally founded our own practice, we accepted a future of uncertainty, although this was countered by great optimism on our part. Looking back, it is clear that a series of events that were wholly out of our control have shaped the practice we now have. Many of the projects we worked on in the early years took on issues for the first time, and this partly explains why it feels that we undertook more research then than we do now. I do, however, believe that we are constantly building upon a set of shared interests, and while the knowledge we have acquired through building is cumulative, our restless curiosity to explore new themes and ideas remains unchanged.
Research at the RIBA: an institutional history 1958–71
Authors: Hay Rowena , Shasore Neal , Samuel Flora
Published: April 2018

Exactly 50 years ago, the Council of the Royal Institute of British Architects (RIBA) launched a new policy and commitment to ‘architectural research.’ At its meeting on 7 December 1967, it set in motion a new programme to accelerate and coordinate the growth of research in architecture, not only in architectural schools but through research centres and in practices. In addition, it reinforced its commitment to building up the Institute's own competence in research, ‘so that it can speak authoritatively on behalf of the profession in the formulation of national research policies and investment programmes.

This paper seeks to historicise the formation, development and promotion of architectural research – what we are terming the idea of architectural research – in light of the Institute's renewed commitment to a research agenda through the appointment in December 2017 of a Vice President for Research (an entirely new role) and the publication of a suite of resources aimed at ‘de-mystifying’ research in practice and promoting the evidencing of design quality and the value of the architect. These initiatives have their origin in the invention of architectural research as a distinct tradition and a post-rationalisation of what had gone before following on from the Oxford Conference in 1958. Furthermore, we situate the invention of this tradition not only within professional and educational debates of the post-war period, but also in the changing and fluctuating landscape of government policy on the promotion and funding of research, itself a response to a perceived cultural and political angst about the UK's shortcomings in productivity and development. In contextualising and problematising the creation and fostering of a ‘research culture’ in the UK architecture profession over the last 60 or so years, we also uncover some of the assumptions behind the contemporary self-conscious pre-occupation with developing the research culture of architects. The paper begins with a discussion of historiography and methodology before moving to the research context of construction history and the role played by the RIBA Research Group in developing the idea of architectural research.
The trajectory of architectural research in the UK and US: 1995–2016
Authors: Lee Joshua D. , Moore Steven A.
Published: April 2018

What has been the trajectory of architectural research in the UK (as reflected in arq: Architectural Research Quarterly) as compared to the United States (as reflected in the Journal of Architectural Education, or JAE) over the past two decades? To answer this question several quantitative methods were used to construct a frame analysis of the various grammars associated with each journal. First we quantify the grammars employed by arq according to the editors’ own categories. Second, we provide a word frequency analysis of arq's article titles and abstracts. Third, we assess the similarities and differences of the content in arq and JAE using the grammars reconstructed in the latter. Fourth, we use these data to reconstruct the trajectory of architectural research in arq. As a final analysis we place arq within the context of the historic emergence of journals recognised by the Avery Index of Architectural Periodicals from 1837 to the present. Our findings reveal numerous conflicts and similarities of content as a representation of the field as a whole and we conclude that these data provide at least three salient patterns worth considering as a foundation for the next two decades: (1) accelerated alienation of research from practice; (2) movement away from literary grammars toward ecological ones; and (3) the explosion of new publication venues and specialised grammars.
Recovery and relapse from severe acute malnutrition after treatment: a prospective, observational cohort trial in Pakistan
Authors: Dale Nancy M , Salim Laila , Lenters Lindsey , Sadruddin Salim , Myatt Mark , Zlotkin Stanley H
Published: April 2018

Objective

Millions of children suffer from severe acute malnutrition (SAM) in low- and middle- income countries. Much is known about the effectiveness of community treatment programmes (CMAM) but little is known about post-discharge outcomes after successful treatment. The present study aimed to evaluate post-discharge outcomes of children cured of SAM.

Design

Prospective, observational cohort study. Children with SAM who were discharged as cured were followed monthly for 6 months or until they experienced relapse to SAM. ‘Cure’ was defined as a child achieving a mid-upper arm circumference (MUAC) of ≥115 mm with ≥15 % weight gain after loss of oedema. Relapse was defined as a child with MUAC<115 mm and/or oedema at any monthly visit.

Setting

Save the Children CMAM programme in Swabi, Pakistan, from January 2012 to December 2014.

Subjects

Children aged 6–59 months (n117) discharged as cured from the CMAM programme were eligible for the study and followed for 6 months.

Results

One hundred children (92·6 %) remained free of SAM, eight (7·4 %) relapsed to SAM, nine (8·3 %) were lost to follow-up and none died. Most relapses occurred within 3 months of discharge (mean time to relapse 73·4 (sd36·2) d). At enrolment, 90 % had moderate acute malnutrition (MAM) and 10 % were not malnourished. By the end of 6 months, 35 % persisted with MAM and the remaining were not malnourished.

Conclusions

In rural Pakistan, fewer than 10 % of children cured of SAM relapsed. The first 3 months is the most vulnerable time.
Millimeter-wave beam-steering high gain array antenna by utilizing metamaterial zeroth-order resonance elements and Fabry-Perot technique
Authors: Bakhtiari Asghar , Sadeghzadeh Ramezan Ali , Naser-Moghaddasi Mohammad
Published: April 2018

Millimeter-wave (mm-wave) beam-steering antennas are preferred for reducing the disruptive effects, such as those caused by high atmospheric debilitation in wireless communications systems. In this work, a compact broadband antenna array with a low loss feed network design is introduced. To overcome the short-range effects on mm-wave frequencies, a feed network – with a modified Butler matrix and a compact zeroth-order resonance antenna element – has been designed. Furthermore, the aperture feed technique has been utilized to provide a broadside stable pattern and improve the delivered gain. A Fabry-Perot layer without the height of the air layer is used. Taking advantage of this novel design, a broadband and compact beam-steering array antenna – capable of covering impedance bandwidths (from 33.84 to 36.59 GHz) and scanning a solid angle of about ~94°, with a peak gain of 17.6 dBi – is attained.
A compact planar circularly polarized eighth-mode substrate integrated waveguide antenna
Authors: Wang Ni , Xu Xiaowen
Published: April 2018

A compact and planar broadband circularly polarized (CP) eighth-mode substrate integrated waveguide (EMSIW) antenna is proposed in this paper. An isosceles right triangular waveguide with one electric sidewall (located on one of its catheti) and two magnetic sidewalls (located on the other two edges of the triangle) is presented to investigate the characteristics of the EMSIW. The closed-form mode solutions of the electromagnetic field components and the cut-off frequencies are derived for all propagating modes in this triangular waveguide. The simulated electromagnetic field distribution is consistent with the analytical results. The resonant frequencies of the EMSIW cavity are then determined. A CP antenna consisting of four EMSIW elements is designed, fabricated, and measured. The measured 3-dB axial ratio bandwidth of the antenna is 21.6% from 4.72 to 5.86 GHz. Within this frequency range, the measured reflection coefficient is below −10 dB, and the measured peak gain in circular polarization at broadside is 6.89 dBic at 5.1 GHz.
Interactions Between Quizalofop-p-ethyl and Acetolactate Synthase–Inhibiting Herbicides in Acetyl-coA Carboxylase Inhibitor–Resistant Rice Production
Authors: Rustom Samer Y. , Webster Eric P. , Blouin David C. , McKnight Benjamin M.
Published: April 2018

A field study was conducted in 2015 and 2016 at the H. Rouse Caffey Rice Research Station (RRS) to evaluate antagonistic, synergistic, or neutral interactions of quizalofop when mixed with ALS-inhibiting herbicides labeled in rice production. Quizalofop was applied at 120 g ai ha−1. Mixture herbicides included penoxsulam at 40 g ai ha−1, penoxsulam+triclopyr at 352 g ai ha−1, halosulfuron at 53 g ai ha−1, bispyribac at 34 g ai ha−1, orthosulfamuron+halosulfuron at 94 g ai ha−1, orthosulfamuron+quinclorac at 491 g ai ha−1, imazosulfuron at 211 g ai ha−1, and bensulfuron at 43 g ai ha−1. All ALS herbicides mixed with quizalofop indicated antagonistic responses for red rice, CL-111, CLXL 745, or barnyardgrass control at either 14 or 28 days after treatment (DAT). At 28 DAT, quizalofop mixed with penoxsulam or bispyribac controlled barnyardgrass 34 to 38%, compared with an expected control of 97%. In addition, these same mixtures controlled red rice, CL-111, and CLXL-745 61 to 67% at 28 DAT compared with an expected control of 96 to 97%. A second application of quizalofop at 120 g ha−1was applied at 28 DAT. At 42 DAT, neutral responses were indicated for all mixtures except with quizalofop mixed with penoxsulam containing products.
Generalized Management Strategies to Delay Herbicide Resistance: A Simulation Approach
Authors: West Argen M. , Altieri Anthony L. , Cryer Steven A.
Published: April 2018

Weed species develop resistance to herbicides through the repeated use of the same herbicide mechanism of action (MOA). Farmers often resort to different MOAs once a weed population has become resistant to the MOA that resulted in a resistant weed population. Delaying herbicide resistance is of great importance to growers due to the limited number of commercially available MOAs. Resistance may occur through monogenic or polygenic traits, and various academic and industrial modeling tools have been developed to help infer cause–effect from multiple interacting factors that may not be intuitive. This work explores various best management practices in delaying weed resistance, and we give details for monogenic and quantitative polygenic resistance models and investigate combinations of management strategies that lead to maximizing the product life span for a herbicide. Management practices under parametric uncertainty are provided to showcase how various practices can be used to extend lifetime product performance before resistance is manifest. Penalty functions associated with choosing a unique management strategy, based upon grower constraints, are the subject of a companion manuscript.
A Pilot Study of Metacognitive Training (D-MCT) for Older Adults with Depression
Authors: C. Schneider Brooke , Bücker Lara , Riker Sarah , Karamatskos Evangelos , Jelinek Lena
Published: April 2018

Abstract. Depression remains one of the most common psychological disorders among older adults. Their response to antidepressants: however, is often unsatisfactory, and despite the proven efficacy of psychotherapies, a large treatment gap remains. Metacognitive Training for Depression (D-MCT) is a low-threshold group intervention. This article examines the feasibility, acceptance, and effects of D-MCT as an add-on intervention among a group of older adults (55+ years; N = 116). Participants completed measures of depression and dysfunctional attitudes, and provided subjective appraisals of the training. Per protocol analyses (n = 55) revealed a significant decrease in depressive symptoms (d = 1.06) and cognitive biases (d = 0.33). The findings demonstrate the feasibility and acceptance of D-MCT among older adults with depression.
Patients’ Perspectives on Treatment with Metacognitive Training for OCD
Authors: Jelinek Lena , Zielke Lotta , Hottenrott Birgit , Miegel Franziska , Cludius Barbara , Sure Anna , Demiralay Cüneyt
Published: April 2018

Abstract. There is much room for improvement in the treatment of obsessive-compulsive disorder (OCD). The current study introduces a newly developed version of Metacognitive Training for OCD (MCT-OCD), inspired by the self-help intervention myMCT as well as by MCT group programs for other disorders. The current study examines the acceptability of the training. Forty-four patients with OCD received four sessions of MCT-OCD in addition to inpatient treatment. At post assessment, patients provided a subjective appraisal of the training. Analyses revealed high acceptability and added value of the MCT-OCD. The current, preliminary version of the MCT-OCD is promising in terms of patient acceptance. Results will be used to improve current shortcomings of the training and to develop a more comprehensive MCT-OCD.
Metacognitive Training Online
Authors: Rüegg Nina , Moritz Steffen , Westermann Stefan
Published: April 2018

Abstract. Psychological interventions such as cognitive-behavioral therapy and metacognitive training (MCT) have proven to be effective treatments for schizophrenia, but only a small number of patients actually gain access to them. Internet-based interventions are effective, but hardly explored for schizophrenia. This pilot study created an Online-MCT to investigate the feasibility, efficacy, and possible negative effects of the program. Fifteen patients participated in this uncontrolled study. During the 6-week intervention phase, two-thirds of participants completed the whole program. Only 6.1 % of all possible negative effects were strongly agreed to. Symptom severity did not change significantly, but 80 % of participants were (very) satisfied with the program, suggesting that internet-based interventions could help reduce the gap in psychological treatments of schizophrenia.
Militant Extremist Mindset and the Assessment of Radicalization in the General Population
Authors: Stankov Lazar , Knežević Goran , Saucier Gerard , Radović Borislav , Milovanović Biljana
Published: April 2018

Abstract. This paper presents new data and reviews the available evidence pointing to the existence of three main ingredients of militant extremist mindset (MEM). Three different methods of item development identified factors that we have labeled Nastiness, Grudge, and Excuse. In other words, there are in our midst nasty people who are more prepared than others to accept, approve, or even advocate the use of violence. When such people feel a grudge, in that they see somebody as threatening to themselves (or to members of the group they belong to) or think that the world is not a hospitable place in which to live, they may resort to violence. This violence is often accompanied by an excuse or justification that refers to a higher authority or a “noble” principle such as religiosity or utopianism. Although all three ingredients may be open to intervention, Grudge might be the most amenable. Social policies related to immigration and procedures for dealing with protest counterculture may be effective in reducing MEM. The most important, however, is the need to espouse principles of diversity and tolerance.
Predicting Everyday Life Behavior by Direct and Indirect Measures of Need for Cognition
Authors: Strobel Anja , Fleischhauer Monika , Luong Cäcilia , Strobel Alexander
Published: April 2018

Abstract. Need for Cognition (NFC) as the intrinsic motivation to engage in and enjoy effortful cognitive endeavors has been a useful predictor of dispositional differences in information processing and task performance in experimental settings. In order to explore the role of NFC in everyday life behavior and to further validate the NFC-IAT, we examined the effects of directly and indirectly assessed NFC on self-reported behavior in a broad variety of situations in daily life where the engagement and joy of thinking could play a role. Accordingly, 95 participants were interviewed with a structured interview about everyday life situations, and direct and indirect measures of NFC were obtained. Both, directly and indirectly assessed NFC independently predicted NFC-related behavior, indicating that the combination of both measures results in a more comprehensive prediction of self-reported behavior. Our results show that NFC can be a helpful predictor of behavior not only concerning academic performance or in experimental paradigms, but also in everyday life.
Welcoming Women into the Geosciences
Authors: Fischer Emily , Adams Amanda , Barnes Rebecca , Bloodhart Brittany , Burt Melissa , Clinton Sandra , Godfrey Elaine , Pollack Ilana , Hernandez Paul
Published: April 2018

Early results of a program to foster the careers of women entering the geosciences demonstrate the effectiveness of several specific factors.
Transmission of a Magnetospheric Pc1 Wave Beam Through the Ionosphere to the Ground
Authors: Fedorov E. N. , Pilipenko V. A. , Engebretson M. J. , Hartinger M. D.
Published: April 2018

A characteristic feature of the upper ionosphere is the occurrence of the ionospheric Alfvén resonator (IAR) and the ionospheric fast‐mode waveguide (IFW), which can trap electromagnetic wave energy in the Pc1 frequency range from fractions of a hertz to a few hertz. This wave trapping ensures the dependence of ionospheric transmission/reflective properties on frequency. We numerically model magnetospheric Alfvén wave transmission through the ionosphere to the ground based on solution of the magnetohydrodynamic full‐wave equations in a realistic ionosphere, whose parameters are reconstructed from the International Reference Ionosphere model. The spatial structure of an incident wave is modeled as a localized beam with a finite latitudinal scale λ⊥ and an azimuthally propagating wave. The IAR and IFW modes are coupled owing to the Hall conductivity and geomagnetic field inclination. Ground spatial and spectral structures of the Pc1 wave (0.1‐ to 6‐Hz band) have been calculated for summer day/night conditions at the Antarctic Halley observatory, though results may be qualitatively applied to any midlatitude site. An incident wave with azimuthal wave vector ky=1.7·10−3 km−1, and λ⊥=102 km has been considered. The model predicts that beneath the incident beam the ground magnetic response “duplicates” its structure after accounting for a π/2 rotation and some latitudinal shift/widening. The transmission has an oscillatory dependence on frequency, thus forming “transmission windows” at resonant frequencies of IAR and IFW modes. The spectra vary depending on distance from an incidence point. Interference between IFW modes is revealed in the nonmonotonic and frequency‐dependent character of latitudinal variations of wave amplitude.
ERG3 and ERG11 genes are critical for the pathogenesis of Candida albicans during the oral mucosal infection
Authors: Zhou Yujie , Liao Min , Zhu Chengguang , Hu Yao , Tong Ting , Peng Xian , Li Mingyun , Feng Mingye , Cheng Lei , Ren Biao , Zhou Xuedong
Published: April 2018

The hyphal development of Candida albicans (C. albicans) has been considered as an essential virulent factor for host cell damage. However, the missing link between hyphae and virulence of C. albicans is also been discovered. Here, we identified that the null mutants of ERG3 and ERG11, two key genes in ergosterol biosynthesis pathway, can form typical hyphae but failed to cause the oral mucosal infection in vitro and in vivo for the first time. In particular, the erg3Δ/Δ and erg11Δ/Δ strains co-cultured with epithelial cells significantly reduced the adhesion, damage, and cytokine (interleukin-1α (IL-1α)) production, whereas the invasion was not affected in vitro. Importantly, they were incapable of extensive hyphal invasion, formation of micro-abscesses, and tongue epithelium damage compared to wild type due to the decrease of the colonization and epithelial infection area in a murine oropharyngeal candidiasis model. The fluconazole (FLC), an antifungal targeted at ergosterol biosynthesis, relieved the epithelial infection of C. albicansin vitro and in vivo even under non-growth inhibitory dosage confirming the virulent contribution of ergosterol biosynthesis pathway. The erg3Δ/Δ and erg11Δ/Δ strains were cleared by macrophages similar to wild type, whereas their virulence factors including agglutinin-like sequence 1 (Als1), secreted aspartyl proteinase 6 (Sap6), and hyphal wall protein-1 (Hwp1) were significantly reduced indicated that the non-toxicity might not result from the change on immune tolerance but the defective virulence. The incapacity of erg3Δ/Δ and erg11Δ/Δ in epithelial infection highlights the contribution of ergosterol biosynthesis pathway to C. albicans pathogenesis and fluconazole can not only eliminate the fungal pathogens but also reduced their virulence even at low dosage.
Wheat-derived arabinoxylan oligosaccharides with bifidogenic properties abolishes metabolic disorders induced by western diet in mice
Authors: Neyrinck Audrey M. , Hiel Sophie , Bouzin Caroline , Campayo Vicenta Garcia , Cani Patrice D. , Bindels Laure B. , Delzenne Nathalie M.
Published: April 2018

Background

Non-digestible carbohydrates present in cereals such as fructans and arabinoxylans represent promising prebiotic nutrients to prevent the development of obesity and related metabolic disorders. OBJECTIVE AND DESIGN: The aim of this study was to determine the corrective effects of wheat bran-derived arabinoxylan oligosaccharides in obese mice fed a western diet (WD). WD was given for 4 weeks before wheat bran extract (WBE) supplementation (5%) for an additional 4 weeks, whereas a control group received the standard diet.

Results

Bifidogenic effect of WBE was evidenced by an induction of both Bifidobacterium animalis and Bifidobacterium pseudolongum in the caecal content. WBE supplementation normalised WD-induced fat-mass expansion, steatosis, hypercholesterolemia, hyperleptinemia, hyperglycemia and hyperinsulinemia reaching the values of control mice. The reduced glucose-dependent insulinotropic polypeptide (GIP) release observed in WD + WBE mice may be a protective mechanism in terms of reducing adipose tissue storage, hepatic steatosis and glucose homoeostasis.

Conclusion

We found that WBE completely abolished WD-induced metabolic disorders. Those results might be useful to take into account nutritional advices to treat obesity and related metabolic disorders such as type 2 diabetes, hypercholesterolaemia and fatty liver diseases when obesity was already established.