bluuebunny/crossref_metadata_2025 huggingface dataset:
Mathematical modeling of the propagation of a plane electromagnetic wave in a strip waveguide with inhomogeneous boundary conductivity
Authors: Д.А. Твёрдый, , Е.И. Малкин, , Р.И. Паровик,
Published: December 2022

В статье проводится математическое моделирование электромагнитной динамики атмосферика. Атмосферик – широкополосный сигнал с максимумом интенсивности в диапазоне частот 8-10 кГц, который распространяется в виде плоской электромагнитной волны в сложной структуре проводящего пространства волновода, образованного поверхностью Земли и ионосферой. Математическая модель процесса описывается краевой задачей для системы уравнений Максвелла. Краевые условия задачи определяют структуру волновода (Perfectly matched layer), параметры проводящего объёма, взаимодействие с неоднородностями в волноводе, временно возникающими (локальное изменение проводимости) или существующими постоянно (прибрежная линия океанов). Математическая модель решается численным методом Finite-Difference Time-domain. Для решения поставленной задачи разработан программный комплекс в среде MATLAB. В результате компьютерных симуляций показано что, наличие искажений основной электромагнитной волны вызвано взаимной интерференцией основной волны и отражённой волны от неоднородности. В результате, наблюдая за параметрами атмосферика возможно установить наличие неоднородности на трассе его распространения. Моделирование процесса взаимодействие электромагнитного излучения с неоднородностью в волноводе может установить связь между параметрами излучения и его неоднородностями.

In the article, mathematical modeling of the electromagnetic dynamics of an atmosferic is carried out. Atmospheric is a broadband signal with a maximum intensity in the frequency range of 8-10 kHz, which propagates in the form of a plane electromagnetic wave in the complex structure of the conducting space of the waveguide formed by the Earth’s surface and the ionosphere. The mathematical model of the process is described by a boundary value problem for the system of Maxwell equations. The boundary conditions of the problem determine the structure of the waveguide (Perfectly matched layer), the parameters of the conducting volume, and the interaction with inhomogeneities in the waveguide, either temporarily arising (local change in conductivity) or existing permanently (coastal line of the oceans). The mathematical model is solved by the Finite-Difference Time-domain numerical method. To solve the problem, a software package was developed in the MATLAB environment. As a result of computer simulations, it is shown that the presence of distortions of the main electromagnetic wave is caused by the mutual interference of the main wave and the reflected wave from the inhomogeneity. As a result, by observing the parameters of the atmospheric, it is possible to establish the presence of inhomogeneity along the path of its propagation. Simulation of the process of interaction of electromagnetic radiation with an inhomogeneity in a waveguide can establish a relationship between the radiation parameters and its inhomogeneities.
Improper Performance in Line of Duty as Reason for Lawyer’s Disciplinary Liability
Authors: Мария Александровна Грузинская,
Published: December 2022

В статье проведён анализ актуального вопроса о ненадлежащем исполнении адвокатом своих профессиональных обязанностей. Рассмотрена проблема определения степени дисциплинарной ответственности адвоката с учетом действующего законодательства РФ. Также рассмотрены основания для возбуждения дисциплинарного производства в отношении адвокатов и обоснована необходимость внесения изменений в законодательство о порядке вынесения заключения квалификационной комиссии по дисциплинарному производству.

The article provides analysis of the pressing issue dealing with the improper performance in the lawyer's line of duty. The focus has been made on determining the degree of disciplinary responsibility of a lawyer in view of the current Russian legislation. In addition grounds for initating disciplinary proceedings against lawyers have been examined with justifying the need to make amendments to the current legislation with regard to the order of making opinion on disciplinary proceedings.
Correlation of Legal Concepts of “Turnover” and “Circulation” in Sales of Medical Products
Authors: Елена Витальевна Дзьоник, , Виталий Романович Дзьоник,
Published: December 2022

В статье речь идет о том, что использование в тексте уголовного закона терминов, которые на первый взгляд имеют тождественные значения, приводит к возникновению проблем у правоприменителей. В особенности ситуация усугубляется тем, что в различных составах преступлений такие понятия могут быть истолкованы по-разному. Посредством обращения к положениям отдельных нормативных правовых актов и доктринальным источникам с использованием системного подхода автором проведен сравнительный анализ терминов «обращение» и «оборот» в сфере медицинской продукции. Изложены точки зрения ученых относительно содержания исследуемых категорий и целесообразности их использования в ряде случаев. Автор настоящего исследования приходит к выводу о том, что каждый случай использования законодателем понятий «обращение» и «оборот» в тексте уголовного закона требует уточнения их содержания.

The use of seemingly identical terminology in the criminal law results in law enforcers' problems. In particular, the situation is aggravated by the fact that such terminology can be interpreted differently depending on corpus delicti. We refer to various legal acts and doctrinal sources and carry out a comparative analysis of the definitions of «circulation» and «turnover» in the sphere of medical products sale using the system approach. The views of scientists regarding the content of the terms in question are given and the appropriateness of their use in specific cases is discussed. We make a conclusion that each use of the terms «circulation» and «turnover» in the text of the criminal law requires a clarification of their content.
Role of Accountant’s Professional Judgement in Fixed Assets Accounting
Authors: Эржэна Чингисовна Цыденова,
Published: December 2022

В связи с вводом в действие в 2022 г. ФСБУ 6/2020 «Основные средства» и ФСБУ 26/2020 «Капитальные вложения» возросло значение профессионального суждения бухгалтера при учете основных средств. Профессиональное суждение играет важную роль в формировании достоверной информации, на основании которой заинтересованные пользователи могут принимать обоснованные экономические решения. Дается определение понятия «профессиональное суждение», исследуется влияние профессионального суждения бухгалтера на формирование качественной информационной базы как для внешних, так и для внутренних пользователей. Анализируются вопросы учета основных средств, которые требуют генерирования профессионального суждения. Подробно исследуются проблемы, возникающие при применении специалистом профессионального суждения в учете основных средств. В заключение автор приходит к выводу о необходимости объективного подхода к формированию результатов профессионального суждения, и рассматривает возможности достижения этого.

The significance of accountant's professional judgement in fixed assets accounting has increased due to the introduction of Federal Standards of Accounting 6/2020 "Fixed Assets" and 26/2020 "Capital Investment" in 2022. A professional judgement plays an important role in forming reliable information to enable interested users to make substantiated economic decisions. We give a definition of "professional judgement" and study the influence of professional judgement on quality information base for both external and internal users. We analyze aspects of fixed assets accounting that require professional judgement. We make a detailed research of problems arising when applying a personal judgement in fixed assets accounting. In the end we make a conclusion about the need in an objective approach to forming the results of professional judgment and consider ways of developing it.
Regional Development in the context of Organization of Interaction of Venture Companies and Training of Entrepreneurs
Authors: Игорь Николаевич Альхимович,
Published: December 2022

В контексте действующего законодательства о поддержке и развитии малого и среднего предпринимательства в практике его применения был сделан довольно значимый акцент в сторону создания благоприятных условий, способствующих активизации создания венчурных предприятий. Статья посвящена взаимодействию крупных и венчурных предприятий в развитии региона, а также правовым основам, способствующим эффективной интеграции. Делается акцент на том, что сегодня малые венчурные предприятия, являясь основным источником инноваций, испытывают существенные трудности при создании и функционировании. На основе проведенного анализа предпринята попытка выявить направления и виды деятельности, способствующие появлению и развитию эффективной интеграции, крупных и венчурных предприятий.

The enforcement of current legislation concerning the support and development of small and medium-sized businesses has created favorable conditions for venture companies. The research is devoted to the cooperation of big business and venture companies in regional development as well as legal foundations contributing to effective integration. We emphasize the fact that currently small venture companies being a source of innovations are facing considerable difficulties at the stages of establishment and functioning. The study is aimed at revealing the directions and types of activities contributing to effective integration and development of big businesses and venture companies on the basis of the analysis we carried out.
New Products on Domestic Credit Market
Authors: Инна Вячеславовна Солдатенкова,
Published: December 2022

В статье рассматриваются кредитные продукты, появившиеся на российском финансовом рынке в 2021-2022 гг. Сделан вывод о преобладании продуктов для розничных клиентов, что влечет за собой увеличение долговой нагрузки населения и выступает одним из рисков финансовой стабильности в экономике РФ. Обозначена необходимость имплементации Правительством новых кредитных продуктов для предприятий реального сектора экономики как определяющего источника инвестиций в основной капитал в условиях санкционного давления.

We look at credit products that appeared on Russian financial market in 2021-2022. We make a conclusion about the dominance of products for retail clients that entails the increase in debt burden on the population and represents one of the risks to financial stability in Russian economy. We emphasize the need for the government to implement new credit products for the companies in the real sector as the main source of investment in the fixed capital under sanctions.
On Illegal Deployment of Production and Consumption Wastes
Authors: Иннокентий Сергеевич Уханов,
Published: December 2022

Производимые современным обществом отходы сейчас представляют одну из глобальных проблем цивилизации. Решение проблемы ухудшения качества окружающей среды из-за увеличивающегося количества отходов производства и потребления включает целый комплекс сложных задач. Чтобы минимизировать ущерб природе, нужно создавать систему правильного обращения с отходами. Одним из наиболее эффективных инструментов контроля за выполнением требований закона в сфере обращения отходов производства и потребления, является лицензирование такой деятельности. Лица, осуществляющие деятельность по транспортировке и утилизации отходов без необходимых лицензий, подлежат привлечению к юридической ответственности.

The waste produced by modern society is now one of the global problems of civilization. Addressing environmental degradation caused by increasing quantities of production and consumption wastes involves a range of complex tasks. To minimize the damage to the nature one must create a proper waste management system. One of the most effective tools for monitoring compliance with the requirements of the law in the field of production and consumption waste management is the licensing of such activities. Persons carrying out waste transportation and disposal activities without the necessary licenses are subject to legal liability.
Procedural Lead as Means of Control and Supervision in Pre-Trial Criminal Proceeding
Authors: Максим Анатольевич Макаренко,
Published: December 2022

Статья посвящена выяснению юридической сущности процессуального руководства в досудебных стадиях уголовного судопроизводства. Оно рассматривается в качестве важнейшего процессуального средства, применяемого как субъектами контроля, так и субъектами прокурорского надзора. Показана полезность дифференциации полномочий, обеспечивающих осуществление руководства процессуальной деятельностью следователей и дознавателей. Обращено внимание на особенности развития процессуального руководства в российском уголовном судопроизводстве.

The article is dedicated to legal clarification of procedural lead at the pre-trial stages of criminal proceeding. It is considered an essential procedural tool used by subjects of processual control and prosecutorial supervision. The article focuses on the utility of powers differentiation aimed at ensuring procedural management over the performance of investigators and survey officers. The attention is drawn to specific features of the development of procedural leaden Russian criminal procedures.
Debatable Issues on Subject of Crime Under Article 128 of Russian Criminal Code
Authors: Алексей Викторович Коротков, , Нелли Владимировна Еремина,
Published: December 2022

В статье исследуются спорные вопросы установления признаков субъекта преступления незаконной госпитализации в медицинскую организацию, оказывающею психиатрическую помощь в стационарных условиях, предусмотренного статьей 128 УК РФ. Авторами предпринята попытка синтезировать отраслевые и локальные нормативноправовые акты с целью уяснения признаков субъекта преступления применительно к статье 128 УК РФ. В статье авторы выделили основные подходы, позволяющие определять признаки субъекта преступления незаконной госпитализации в медицинскую организацию, оказывающую психиатрическую помощь в стационарных условиях.

The article examines disputable issues of establishing signs of a subject of crime with regard to unlawful hospital admission to a medical institution providing mental health care in hospital settings stipulated by art. 128 of the Criminal Code of the Russian Federation. The authors attempt to synthesize sectoral and local regulatory legal acts with the purpose to clarify signs of subject of crime in relation to Art.128 of the Russian Criminal Code. The article identifies major approaches for determining signs of subject of crime of unlawful hospitalization to a medical institution rendering psychiatric care on an impartial basis.
Investigator's activity as Important Tool for Securing Human and Civil Rights and Freedoms in Criminal Proceedings
Authors: Сайнбаяр Наранбаатар,
Published: December 2022

В статье рассматриваются проблемные аспекты, связанные с деятельностью следователя, как важного инструмента обеспечения прав и свобод человека и гражданина в уголовном судопроизводстве. Автором проанализированы вопросы реализации органами предварительного следствия полномочий по производству процессуальных действий, направленных на обеспечение прав и свобод человека и гражданина. Определены понятие, предмет, особенности и виды мер по обеспечению прав и свобод человека и гражданина.

We consider problematic aspects related to the activities of an investigator as an important tool for securing human and civil rights and freedoms in criminal proceedings. We analyze the issues of the powers of preliminary investigation bodies when carrying out procedural actions aimed at ensuring the rights and freedoms of man and citizen. The concept, subject, features and types of measures to secure human and civil rights and freedoms are determined.
Tools of Digital Transformation of Research and Educational Organizations
Authors: Олег Викторович Бургонов, , Ольга Игоревна Константинова, , Константин Аркадьевич Платонов,
Published: December 2022

В статье анализируется система современных инструментов виртуальной коммуникации в контексте цифровой трансформации, предлагается карта по четырём основным блокам: видеоконференции, инструменты совместной работы, мессенджеры и соцсети и системы дистанционного обучения. По каждому блоку проведен анализ наиболее распространённых решений, рассмотрены их сходства и различия, особенности использования и интеграции в бизнес-процессы. Проводится сравнение отечественных и западных разработок по основным категориям программного обеспечения и делаются выводы о ключевых требованиях к типичной для научно-образовательных организаций связке "Система дистанционного обучения-Трекер-Мессенджер" в экономическом и техническом смысле. Рассматриваются проблемы импортозамещения для ряда решений, которые либо уже недоступны, либо находятся в зоне риска, поскольку могут уйти с российского рынка. Рассмотрены причины и следствия популярности тех или иных решений, практика адаптации функционала софта под педагогические цели, возможности и ограничения различных решений и экономические аспекты использования сервисов.

We analyze the system of modern tools of virtual communication in the context of digital transformation and introduce a map of four mainblocks, namely videoconferences, tools for team-work, messengers, social networks and distance learning systems. We analyze the most common solutions for each block, look at their differences and similarities, features that determine their use and integration into business processes. We compare domestic and international software and make conclusions concerning the key requirements to the typical for research and educational institutions combination of Distance Learning System - Tracker -Messenger from economic and technical point of view. We consider the problems of import replacement for certain solutions that are not available or running the risk of leaving Russian market. We look at the reasons and consequences of the popularity of some solutions as well as the practice of adapting the software functional to pedagogic aims, opportunities and limitations of various solutions and economic aspects of service application.
Complex Development of Rural Territories in Dynamic Market Environment
Authors: Михаил Владимирович Москалев, , Тамара Гамидовна Виноградова,
Published: December 2022

В материалах статьи обосновывается необходимость перехода на формирование (трансформацию) механизма управления, позволяющего координировать и согласовывать деятельность разнородных территориальных субъектов во времени и пространстве (целостная социально-экономико-экологическая система). Такая смена вектора обусловливает новые требования к реализации стратегии развития территории, выбору приоритетных направлений, обеспечивающих динамику использования конкурентных преимуществ, созданию адекватных организационно-экономических условий для всех субъектов (формирование конкурентной среды).

We substantiate the need in the transition to formation (transformation) of management mechanism enabling to timely and spatially coordinate and adjust the activity of promiscuous territorial subjects (an integral socio-economic-environmental system). Such a direction change stipulates new requirements to the implementation of the territory development strategy, the choice of priority directions ensuring the dynamics of the use of competitive advantages, the creation of relevant organizational and economic conditions for all the subjects (the formation of competitive environment).
Features of Legal Liability of State as Participant of Civil Legal Relations
Authors: Елизавета Андреевна Шибанова, , Юрий Анатольевич Кудрявцев,
Published: December 2022

В статье проведен анализ юридической ответственности государства в гражданских правоотношениях. Сформулированы основания, по которым государство может быть привлечено к гражданско-правовой ответственности, изучены особенности мер ответственности. В качестве вывода предложено регламентировать в законе порядок привлечения государства к гражданской ответственности, обозначить перечень мер юридической ответственности, к которой могут привлекаться должностные лица в рамках нарушения норм гражданского права, а также предложено обозначение состава выморочного имущества в рамках статьи 1151 ГК РФ.

We carry out the analysis of legal liability of the state in civil legal relations. The grounds for the state to be made liable are formulated, the characteristics of responsibility are studied. In conclusion, we suggest regulating the ways of holding the state liable as well as specifying the responsibility of officials for the violation of civil law norms. We also specify what can be refered to as escheat within provision 1151 of the Civil Code of the Russian Federation
Regulatory Legal Acts as Sources of Contract Law: Federal Level
Authors: Андрей Владимирович Кузьмин,
Published: December 2022

Рассматриваются нормативные правовые акты федерального уровня как элементы системы источников договорного права. Автором сформулированы выводы о структуре системы источников договорного права, основой которой выступают нормативные правовые акты федерального уровня. Приведен уникальный пример правового регулирования договорных отношений нормами Федерального конституционного закона; отражено место и предметная сфера регулирования нормативных правовых актов разного уровня в системе источников договорного права.

The article examines federal regulatory legal acts as an element of the contract law sources system. The author formulates conclusions about the system of sources of the contract law the basis whereof is considered to be federal regulatory legal acts. The article provides a unique example of legal regulation of contractual relations by the Federal Constitutional Law. The paper also reflects the place and the subject area of regulating different normative-legal acts in the system of sources of contract law.
Relevant Issues of Statute of Limitation in Protecting Citizens’ Property Rights to Residential Premises: Generalization of Judicial Practice
Authors: Гузель Римовна Игбаева, , Марина Григорьевна Касьянова,
Published: December 2022

В статье на основе анализа судебной практики рассматриваются актуальные проблемы вещно-правовых способов защиты права собственности граждан на жилое помещение. Особое внимание уделено определению срока исковой давности в виндикационных требованиях, раскрывается проблема претензионного порядка в негаторных исках, проблема давности владения в исках о признании права собственности.

Based on the analysis of judicial practice, the article examines relevant issues related to real-law methods of protecting the property rights of citizens to residential premises. Particular attention is paid to the definition of the limitation period in vindication claims, to revealing the problem of claim procedure in negatory claims as well as to disclosing the problem of the limitation period in claims for recognition of ownership rights.
First Total Synthesis of (–)-Merrillianin
Authors: Shiina Isamu , Iizumi Takashi , Taniguchi Saori , Sugimoto Masuhiro , Shimazaki Takahisa , Yamai Yu-suke , Ogawa Go , Yamada Tetsuro , Shinohara Shojiro , Kageyama Yosuke , Kuboki Teppei , Suwa Yuki , Yonekura Keita , Ito Keiichi , Toyoyama Kiyotaka , Tateyama Satoru , Mori Takahiro , Murata Takatsugu
Published: December 2022

The first total synthesis of (–)-merrillianin (1), which is a natural sesquiterpene with a tri- fused structure having a cyclopentane ring and five- and seven-membered lactone parts, is demonstrated. This asymmetric total synthesis enabled the absolute stereo structure determination of naturally occurring (–)-1.
Comparing Top-Down Proteoform Identification: Deconvolution, PrSM Overlap, and PTM Detection
Authors: Tabb David , Jeong Kyowon , Druart Karen , Gant Megan , Brown Kyle , Nicora Carrie , Zhou Mowei , and Metabolome The Milk Microbiome , Chamot-Rooke Julia
Published: December 2022

Generating top-down tandem mass spectra (MS/MS) for complex mixtures of proteoforms has become possible through improvements in fractionation, on-line separation, dissociation, and mass analysis. The algorithms to match MS/MS to sequences have undergone a parallel evolution, with both spectral alignment and peak matching being paired with diverse methods for scoring proteoform-spectral matches (PrSMs). This study assesses state-of-the-art algorithms for top-down identification through three distinct challenges. The first is identifying a large yield of PrSMs while controlling false discovery rate (FDR) in identifying thousands of proteoforms from complex cell lysates via four software workflows: ProSight Proteome Discoverer, TopPIC, Informed Proteomics, and pTop. The second is the deconvolution of data from both Thermo Orbitrap-class and Bruker maXis Q-TOF instruments to produce consistent precursor charge and mass determinations while generating fragment mass lists to optimize identification. The third attempts to detect diverse post-translational modifications (PTMs) in proteoforms from bovine milk and human ovarian tissue. The data demonstrate that existing software suites produce admirable sensitivity, in some cases identifying a third of collected MS/MS with FDR controlled below 2%; the overlap in these PrSMs, however, illustrates real value in searching data with multiple search engines. Differences among identification workflows seem to result from each search algorithm incorporating its own deconvolution algorithm. By transmitting deconvolution data from multiple deconvolution routes (Thermo Xtract, Bruker Auto MSn, Mascot Distiller, TopFD, and FLASHDeconv) to the downstream TopPIC search algorithm, we were able to detect common causes of deconvolution disagreement. The detection of PTMs was very inconsistent among search algorithms, with some workflows suggesting as little as 1% of PrSMs from bovine milk were singly-phosphorylated while other workflows found that 18% of PrSMs were singly-phosphorylated. Taken together, these results make a strong argument for top-down researchers to adopt a standard practice of analyzing each MS/MS experiment with at least two different search engines.
Systemic anti-tumor immunity mediated by photodynamic therapy using injectable chitosan hydrogels for intra-tumoral and sustained drug delivery
Authors: Gierlich Piotr , Donohoe Claire , Behan Kevin , Kelly Daniel J. , Senge Mathias , Gomes-da-Silva Ligia C.
Published: December 2022

Photodynamic therapy (PDT) is an anti-cancer therapy with proven efficacy; however, its application is often limited by prolonged skin photosensitivity and solubility issues associated with the phototherapeutic agents. Injectable hydrogels that can effectively provide intra-tumoral delivery of photosensitizers with sustained release is attracting increased interest for photodynamic cancer therapies. However, most of the hydrogels for PDT applications are based on systems with high complexity and often, pre-clinical validation is not provided. Herein, we provide a simple and reliable pH-sensitive hydrogel formulation that presents proper rheological properties for intra-tumoral injection. For this, Temoporfin (m-THPC), which is one of the most potent clinical photosensitizers, was chemically modified to introduce functional groups that act as cross-linkers in the formation of chitosan-based hydrogels. The introduction of -COOH groups gave rise to a water-soluble derivative, named as PS 2, that was the most promising candidate. Although PS 2 was not internalized by the target cells, its extracellular activation cause effective damage of the cancer cells which was likely mediated by lipid peroxidation. The injection of the hydrogel containing PS 2 in the tumors was monitored by high frequency ultrasounds and in vivo fluorescence imaging which confirmed the sustained release of PS 2 for at least 72 h. Following local administration, light exposure was conducted one (single irradiation protocol) or three (multiple irradiation protocol) times. The latter deliver the best therapeutic outcomes which included complete tumor regression and systemic anti-cancer immune responses. Immunological memory was developed as ~ 75% of the mice cured with our strategy rejected a second rechallenge with live cancer cells. Additionally, failure of PDT to treat immunocompromised mice bearing tumors reinforces the relevance of the host immune system. Finally, our strategy promotes anti-cancer immune responses that lead to the abscopal protection against distant metastases.
C-H Bond Activation via Concerted Metalation-Deprotonation at a Palladium(III) Center
Authors: Bouley Bailey , Tang Fengzhi , Bae Dae Young , Mirica Liviu
Published: December 2022

Herein we report the direct observation of C-H bond activation at an isolated mononuclear Pd(III) center. The oxidation of the Pd(II) complex (MeN4)PdII(neophyl)Cl (neophyl = -CH2C(CH3)2Ph; MeN4 = N,N′-di-tert-butyl-2,11-diaza[3.3](2,6)pyridinophane) using the mild oxidant ferrocenium hexafluorophosphate (FcPF6) yields the stable Pd(III) complex [(MeN4)PdIII(neophyl)Cl]PF6. Upon the addition of an acetate source, [(MeN4)PdIII(neophyl)Cl]PF6 undergoes Csp2-H bond activation to yield the cyclometalated product [(MeN4)PdIII(cycloneophyl)]PF6. This metallacycle can be independently prepared, allowing for a complete characterization of both the starting and final Pd(III) complexes. The C-H activation step can be monitored directly by EPR and UV-Vis spectroscopies, and kinetic isotope effect (KIE) studies suggest the C-H activation likely occurs after the rate determining step. Density functional theory calculations support that molecular isomerization/ligand rearrangement is rate limiting and proceeds through a κ3 ligand geometry. Overall, this study represents the first example of discrete C-H bond activation occurring at a Pd(III) center through a concerted metalation-deprotonation mechanism, akin to that observed for Pd(II) and Pd(IV) centers.
Reconstruction of NMR Relaxation Rates from Coarse-Grained Polymer Simulations
Authors: Gravelle Simon , Beyer David , Brito Mariano , Schlaich Alexander , Holm Christian
Published: December 2022

NMR relaxometry is a powerful and well established experimental approach to characterize dynamic processes in soft matter systems. All-atom (AA) resolved simulations are typically employed to gain further microscopic insights while reproducing the relaxation rates R1. However, such approaches are limited in time and length-scales that hinder modeling of systems like long polymer chains or hydrogels. Coarse-graining (CG) can overcome this barrier at the cost of loosing atomistic details that impede the calculation of NMR relaxation rates. Here, we address this issue by systematic characterization of R1 while performing systematic measurements on a PEG-H2O mixture at two different levels of details: AA and CG. Remarkably, we show that NMR relaxation rates R1 obtained at the CG level obey the same trends when compared to AA calculations, but with a systematic offset. We find this offset to be due to, on the one hand, the lack of an intra-monomer component and, on the other hand, the inexact positioning of the spin carriers. We show that the offset can be corrected for quantitatively by reconstructing a posteriori the atomistic details from the CG trajectories.
Inhibition of Ubiquitin Phosphorylation by Nucleoside Analogues
Authors: Lambourne Olivia A , Bell Shane , Wilhelm Lea P , Yarbrough Erika B , Holly Gabriel G , Russell Oliver M , Alghamdi Arwa , Fdel Azeza M , Varricchio Carmine , Lane Emma L , Ganley Ian G , Jones Arwyn T , Goldberg Matthew S , Mehellou Youcef
Published: December 2022

The phosphorylation of ubiquitin by the mitochondrial protein kinase PINK1, upon mitochondrial depolarization, is an important step in the repair and recycling of the mitochondria via mitophagy. As mutations in PINK1 can cause early-onset Parkinson’s disease (PD), there has been a growing interest in small molecule modulators of PINK1-mediated mitophagy as potential PD treatments. In this work, we show that in HeLa cells, primary mouse fibroblasts and astrocytes, N6-substituted adenosines, such as N6-(2- furanylmethyl)adenosine (known as kinetin riboside) and N6-benzyladenosine, inhibit ubiquitin phosphorylation that is induced by established mitochondrial depolarizing agents, CCCP and niclosamide. Although these nucleoside analogues inhibited niclosamide- and CCCP-induced ubiquitin phosphorylation, they did not prevent the mitochondrial membrane depolarization. Notably, treatment of cells with these nucleoside analogues alone induced low level mitophagy and did not cause mitochondrial fragmentation. Together, this work presents N6-substituted adenosines as new inhibitors of CCCP- and niclosamide-induced PINK1-mediated ubiquitin phosphorylation and highlights their potential utility in treating aged and sporadic PD as well as Lewy body dementia patients who have elevated levels of phosphorylated ubiquitin.
O-Methyl-N-Nitroisourea as a NCO Surrogate in Cu-Catalyzed Alkane C-H isocyanation. A Masked Isocyanate Strategy.
Authors: LANDAIS Yannick , Lusseau Jonathan , Robert Frédéric
Published: December 2022

The Cu-catalyzed C-H activation of alkanes in the presence of O-methyl-N-nitroisourea affords a facile entry to O-methyl-N-alkylnitroisoureas, shelf stable and benign isocyanate precursors. The latter is then readily converted into carbamates and ureas via an uncommon chloride-mediated demethylation process. O-methyl-N-nitroisourea is available in two steps and large-scale from urea and constitutes an easy to handle NCO surrogate. The methodology has also been applied to the synthesis of a methylisocyanate (MIC) precursor, a valuable synthon for pharmaceutical and agrochemical purposes and for the post-functionalization of a low density polyethylene.
STUDY ON RESEARCH WORKS AND FUTURE RESEARCH DIRECTIONS OF POST-GRADUATE PROGRAM AT PATHOLOGY DEPARTMENT, IAAS, RAMPUR, CHITWAN, NEPAL
Authors: Bhusal Khuma Kumari , Devkota Sabina , Malla Santoshi , Magar Saraddha Khasu
Published: December 2022

The Institute of Agriculture and Animal Science (IAAS) under Tribhuwan University (TU) has been carrying out various disciplinary and system research works through post-graduate students' research and publishing their findings through the M.Sc.Ag and Ph.D. thesis dissertations. Various thesis written by researchers under IAAS were collected and the appraisal of pathological research works on major cereals, vegetable crops, legume crops, oilseed crops and high-value crops along with ideas on management practices was done with the help of a thorough literature review. Data were gathered from IAAS/TU libraries, Rampur Library, Kritipur library, GAASC library and IAAS journals. A total of 68 types of research were conducted at IAAS. It is revealed that major diseases associated with cereals area brown spot of rice, rice blast, yellow rust of wheat, helminthosporium leaf blight of wheat, spot blotch of wheat and leaf blast of finger millet. Similarly, diseases of vegetables include late blight of potato, a white mold of french beans. The major diseases of legumes are wilt of lentil & chickpea, powdery mildew of pea, anthracnose of soybean and those of oilseeds are mainly leaf blights. Large cardamom, greatly known as high- value crop, is found to be suffered from Chirkey Foorkey and leaf blight diseases. Fungal pathogens cause most of the diseases in almost all crops. The management practices at their best results included the use of biological agents along with commonly available fungicides. The study found out a research gap in agricultural pathology as well. It also luminated the future area of research works that is lacking in current research works
IDEOTYPE DESIGN FOR HIGH GRAIN YIELD POTENTIAL ON HEAT STRESS WHEAT
Authors: Janak Bhandari , Barsha KC , Biddhya Pandey , Preetia , Kayastha , Himani Chand , Pawan Lamichhane , Roka Magar Bimal , Prakash Baduwal , Muktiram Poudel
Published: December 2022

A wheat ideotype is represented by a set of cultivar parameters in a model, which could be optimized for best wheat performance under projected heat-tolerant conditions. Globally, heat stress significantly limits the yield. So, a major challenge of the 21st century is to achieve food supply security under a changing climate androughly a doubling in food demand by 2050. Global warming became a serious threat to crop productivity as heat stress sig nificantly reduced grain yield. Although the different traits related to high grain yield have beenidentified, the combination of traits that optimize high grain yield has not been established. The later sown experiments were exposed to higher temperatures at the critical reproductive and grain-filling stages of development. The influence of high temperatures was highest during anthesis, and with every 1% increase in average maximum temperature over the optimum of 25 degrees Celsius, grain yield was lowered by 4% to 7%. High temperature reduced yield, plant height, grain weight and days to anthesis and maturity, and increased the percentage of screenings and grain protein content. Genotypes that produced higher yield under heat stress had shorter days to flowering and maturity, higher NDVI during grain filling, greater chlorophyll content at the milk stage of grain fill, taller plants, greater grain weight and number, and lower screenings compared with the benchmark cultivar Sun top (main factors contributing to yield increase/parameters).
ACCIONES DE PROTECCIÓN ANTE LA INSEGURIDAD CIUDADANA DESDE LA ESCUELA: VISIÓN ESTRATÉGICA PREVENTIVA FAMILIAR 2015- 2021
Authors: Jaén García Juan José , Jiménez Agramonte Kelly William , Julca Ambulay Denitza Elizabeth , Landa Agurto César , Córdova Pintado Manuel Jesús
Published: December 2022

En esta investigación se planteó como objetivo promover acciones de protección ante la inseguridad ciudadana desde la escuela y la familia. La metodología responde al enfoque cualitativo. Para la recolección de datos, se hizo una investigación documental en diversas fuentes, en las que se identificaron los aspectos más relevantes conocidos y controvertidos que permitieron recopilar información teórica sobre el tema y tener una visión crítica sobre la inseguridad ciudadana y cómo esta afecta a los estudiantes en particular.  La búsqueda de la información se hizo vía online usando las palabras clave en buscadores de repositorios, revistas, etc. Esto ayudó a comparar información y realizar una apreciación crítica que conlleve a promover acciones de protección escolar, bajo un nuevo enfoque de seguridad, basado en las personas y con eficacia en la participación ciudadana. En las conclusiones se resuelve que el gobierno promueve la seguridad ciudadana desde un punto de vista represivo y preventivo, por lo que es necesario fomentar la actuación preventiva en el sistema educativo y en las familias con el propósito de minimizar los riesgos y promover acciones de protección ante la inseguridad ciudadana.
COMPETENCIAS DIGITALES Y LIDERAZGO DIRECTIVO
Authors: Espiche Sánchez Silvia Virginia
Published: December 2022

El objetivo del estudio fue hacer una recomendación para un programa de habilidades digitales para mejorar el liderazgo gerencial en las instituciones públicas de educación básica en la región de Chiclayo. El método de investigación fue básico con un diseño no empírico activo y representa un estudio transversal, por lo tanto, solo se miden individualmente las variables de interés y se contrastan las hipótesis creadas en primer lugar que pueden ser autenticadas. La población fueron 50 directores y superintendentes adjuntos de una institución educativa pública del cantón en Chiclayo. Utiliza la encuesta como método y una lista de preguntas como instrumento, ambos aprobados por opinión profesional. La propuesta desarrollada fortaleció efectivamente el liderazgo gerencial en las instituciones públicas de educación primaria de la ciudad de Chiclayo, se concluyó del análisis producido. De esta manera, se atendió la necesidad de formación que identificaron los directivos de las instituciones educativas a nivel de gestión digital.
DESEMPEÑO LABORAL EN LA UNIDAD EJECUTORA 304 DE LA REGIÓN LAMBAYEQUE
Authors: Torres Uceda Diana Lucia , Córdova Chirinos José William
Published: December 2022

Esta investigación posee el objetivo de establecer el nivel de desempeño laboral en la Unidad Ejecutora 304 de la Región Lambayeque. El problema es: ¿Cuál es el nivel de desempeño laboral en la Unidad Ejecutora 304 de la Región Lambayeque?; es de tipo descriptiva; se aplicó un cuestionario conformado por 10 interrogantes, y como técnica se empleó la encuesta. La población está conformada por 82 trabajadores, la cual se constituye en una muestra; para el proceso de datos se utilizó el SPSS 25, obteniendo los siguientes resultados, el 78% de los participantes declaran no sentirse satisfechos con el trabajo que desarrollan, toda vez que existen algunas deficiencias que entorpecen el normal desenvolvimiento de sus operaciones, en tanto, el 22% está de acuerdo con su labor encargada. En conclusión, los elementos que requieren mayor atención por la Unidad Ejecutora 304, son la productividad laboral, la orientación de resultados y las relaciones interpersonales mediante la puesta en práctica de ciertas estrategias que permitan coadyuven al desempeño laboral óptimo en los trabajadores, contribuyendo a desarrollar sus capacidades, habilidades, y adiestramiento en el trabajo, para conseguir un sobresaliente rendimiento y el cumplimento de los objetivos.
Efek Terapi Murottal Surat Ar-Rahman terhadap Tingkat Kecemasan Ibu Bersalin Kala I
Authors: Susiloningtyas Is , Sutrisminah Emi , Astuti Yuli , Jayanti Murni
Published: December 2022

Anxiety is an emotional disorder that is often experienced by mothers in labor. The effects of anxiety in childbirth can trigger the release of excess catecholamine levels, which can result in decreased blood flow to the uterus and can lead to prolonged labor during the active phase of labor. One of the non-pharmacological efforts to overcome this problem is murottal therapy. This study aims to determine the effect of Murottal Surat Ar-Rahman therapy on the level of anxiety in mothers during the active phase of labor at Esti Husada Clinic. The study used a Quasy Experiment design. Quantitative design using the Non-Equivalent Control Group. The sampling technique is Accidental sampling. The number of samples was 22 mothers who gave birth during the first stage of the active phase consisting of 11 respondents in the control group and 11 respondents in the experimental group. Quantitative data analysis used the Wilcoxon test. Results are obtained p-value=0.005, which means there is an effect of Murottal Surat Ar-Rahman therapy on the level of anxiety in the mother during the active phase of labor. The level of maternal anxiety level during the first stage of labor in the control group during the pretest (54.5%) and posttest (63.6%), namely at a moderate level of anxiety, while the anxiety level of the mother during the first stage of the active phase in the intervention group before doing murottal therapy is experiencing moderate anxiety (54.5%), but after being given murottal therapy it changed to mild anxiety (72.7%).
Pendekatan Fenomenologi tentang Pola Asuh Ibu Balita Stunting
Authors: Sumiarti Wenti , Ningsih Lisma , Sumaryono Dino , Patroni Rini , Simbolon Demsa
Published: December 2022

The high prevalence of stunting is caused by poor parenting. Data from the Health Profile of Bengkulu Province in 2019 showed that as many as 700 toddlers experienced stunting in Seluma Regency, and as many as 35 cases of toddlers experienced stunting in the working area of the Babatan Health Center. This study aims to obtain an overview of the parenting pattern of stunting in Air Petai Village, Sukaraja District, Seluma Regency. This study uses a qualitative method with a phenomenological approach. Sources of data were obtained through in-depth interviews, observation, and document review. The informants of this study consisted of the main informants, namely 6 mothers with stunting toddlers, and 2 supporting informants, namely the Posyandu Cadre in Air Petai Village and nutrition practitioners (TPG) at the Babatan Health Center. The results showed that early initiation of breastfeeding was not applied to all toddlers. Some informants do not breastfeed until the child is 2 years old. The informant thought that if breast milk was given until the age of 2 years, it would be difficult to do weaning. Some informants often forget to wash their hands before feeding their children because they are busy taking care of the household. Health workers and Posyandu cadres hoped can carry out health promotions to mothers in Air Petai Village regarding good parenting, especially to pregnant and lactating women.
Uji Toksisitas Akut Nanoinsektisida Tembakau (Nicotiana tabacum L.) terhadap Mencit
Authors: Handayani Sri Wahyuni , Susilo Dwi , Wardani Arum Triyas , Anggraeni Yusnita Mirna
Published: December 2022

Tobacco (Nicotiana tabacum) is a plant that can be used as a natural insecticide. Tobacco extracts can be made as alternative nanoinsecticides to be used as Aedes aegypti control. This study aims to obtain information on the toxicity of tobacco nanoinsecticides and obtain the LD50 of tobacco nanoinsecticides in mice. The research was conducted at the Center for Disease Vector and Reservoir Research and Development (B2P2VRP) with a pure experimental method. The results showed that the particle size ranged from 26.9; 53.7 and 89nm. The results of the metal content test with an Atomic Absorption Spectrophotometer (AAS) showed the presence of Ag content in the nanoinsecticide solution made. Spectrophotometry measurements showed a peak at a wavelength of 420 nm and functional group bonds were formed. The characteristic SEM photo shows the particle morphology in the form of round-face crystals. The results of the toxicity test using the OECD 423 LD50 method at 2500mg/kg BB showed that tobacco nanoinsecticides were in the slightly toxic category. Administration of tobacco nanoinsecticides causes toxic symptoms in the form of decreased cardiac activity, convulsions, and decreased movement activity, while from the histopathological test results, the number of kidney injuries is in the range of 10 to 25%.
Bir Turistik Ürün Olarak Medikal Turizmin Değerlendirilmesi (Evaluation of Medical Tourism as a Touristic Product)
Authors: Çalhan Harun , Arıcı Ayşegül
Published: December 2022

Bu çalışmanın amacı, medikal turizm paydaşlarının bakış açısı ile Türkiye’de medikal turizmin bir turistik ürün olarak değerlendirilmesidir. Çalışma kapsamında 15.10.2019-15.05.2020 tarihleri arasında Antalya’da farklı kamu ve özel kuruluşlarda görev yapan sağlık çalışanları ile otel ve seyahat acentası yöneticilerinden oluşan 72 medikal turizm paydaşı ile görüşmeler yapılmış ve toplanan veri içerik analizi ile incelenmiştir. Paydaş görüşlerine bağlı olarak Türkiye'de medikal turizmin SWOT analizi yapılmış ve öneriler geliştirilmiştir. Araştırma sonuçlarına göre Türkiye’nin (a) güncel ve güven veren teknolojilerin takip edilmesi/uygulanması, üst kalitede tıbbi eğitim/tıbbi gelişim ve nitelikli ve deneyimli hekimlerin olması, (b) rakiplerden daha ucuz, düşük fiyat, uygun fiyat, daha kaliteli ve daha ucuz hizmetler sunması ve (c) coğrafi konum/jeopolitik konum ve kolay/kısa sürede ulaşılabilirlik konularında üstün olduğu ortaya çıkmıştır. Diğer taraftan Türkiye’nin (i) kamu hastanelerinde yabancı dil bilen işgücü azlığı, (ii) tanıtım ve tutundurma faaliyetlerinin yetersiz olması ve (iii) terör olayları ile çevre ülkelerde devam eden siyasi istikrarsızlıklar konularında zayıflıklar/zorluklar olduğu görüşü ortaya çıkmıştır.
Bu makale Ayşegül ARICI’nın Erciyes Üniversitesi Sosyal Bilimler Enstitüsü Turizm İşletmeciliği Anabilim Dalı’nda hazırlamış olduğu tez çalışmasından türetilmiştir.