bluuebunny/crossref_metadata_2025 huggingface dataset:
976-P: Post Market Clinical Follow-Up (PMCF) Registry to Demonstrate the Long Term Safety of the Eversense CGM System
Authors: CARLSON GRACE , TWEDEN KATHERINE S. , MDINGI COLLEEN , HARIDAS HARITHA
Published: June 2019

Background: Eversense CGM is the first implantable long-term continuous glucose monitoring system. Prior studies evaluated the safety of the system using a study design of one insertion and removal cycle. The purpose of this prospective PMCF registry was to assess the long-term safety of the Eversense CGM System after repeated insertions.

Methods: Eversense users from 15 European countries were followed prospectively until the first 100 participants completed their 4th insertion cycle. Visits were made every 90 to 180 days (dependent on sensor configuration) to replace sensors once sensor end life was reached. At each visit, Adverse Events (AEs) that occurred during the visit or during use since the previous visit were recorded. The primary endpoint was the rate of serious adverse events (SAEs) that were device-related, procedure-related, or drug (dexamethasone acetate) related through the sensor insertion/removal cycles.

Results: 3066 participants were enrolled in the study with 43% on 2 or more sensor cycles. There were no device- or procedure-related SAEs reported. A total of 130 potentially-related AEs were reported, of which 106 were adjudicated as related or possibly/probably related to the device or insertion/removal procedure.

Conclusion: Repeat insertions of the Eversense CGM confirmed the promising safety profile of prior studies and show it to be safe for long-term continuous use.

Disclosure

G. Carlson: Consultant; Self; Abbott Laboratories, Edwards Lifesciences Corporation, Senseonics, St. Jude Medical. K.S. Tweden: Employee; Self; Senseonics. C. Mdingi: Employee; Self; Senseonics. H. Haridas: Employee; Self; Senseonics.
981-P: GIP and GLP-1 Potentiate Sulfonylurea-Induced Insulin Secretion in HNF1A Diabetes
Authors: CHRISTENSEN ALEXANDER S. , HAEDERSDAL SOFIE , STORGAARD HEIDI , ROSE KATHRINE , HANSEN NINA L. , HOLST JENS J. , HANSEN TORBEN , KNOP FILIP K. , TINA VILSBØLL
Published: June 2019

Sulfonylurea (SU) is considered first-line treatment of hepatocyte nuclear factor 1-alpha (HNF1A)-diabetes but rarely provides lasting glycemic control. In a randomized, double-blinded, cross-over study, we evaluated the insulinotropic effect of exogenous glucose-dependent insulinotropic peptide (GIP) and glucagon-like-peptide 1 (GLP-1), respectively, with and without SU in patients with HNF1A-diabetes. Ten patients with HNF1A-diabetes ([mean±SD] BMI 22.4±1.5 kg/m2; HbA1c 6.0±0.6% [42.3±6.6 mmol/mol]) and 10 matched healthy controls (BMI 22.2±2.4 kg/m2; HbA1c 5.1±0.3% [31.9±2.8 mmol/mol]) were subjected to six 2 h glucose clamps (time 0-60 minutes at fasting plasma glucose (FPG) and 60-120 minutes at 1.5 × FPG) preceded by administration of 1 mg of glimepiride or placebo (PLA) at time -90 min. Two-hour infusion of either GIP (1.5 pmol/kg/min), GLP-1 (0.5 pmol/kg/min) or saline (NaCl) was initiated at time 0 min. Insulin secretion was quantified as baseline-subtracted area under the curve (bsAUC) from 0 to 120 minutes (Figure). In patients with HNF1A-diabetes both SU+GIP and SU+GLP-1, respectively, showed significantly greater insulin secretion vs. PLA+GIP, PLA+GLP-1, SU+NaCl and PLA+NaCl, while this was only the case for SU+GLP-1 in controls.

In conclusion, GIP and GLP-1 potentiate SU-induced insulin secretion in patients with HNF1A-diabetes and in nondiabetic controls.

Disclosure

A.S. Christensen: None. S. Haedersdal: None. H. Storgaard: Advisory Panel; Self; Boehringer Ingelheim Pharmaceuticals, Inc. K. Rose: None. N.L. Hansen: None. J.J. Holst: Advisory Panel; Self; Novo Nordisk A/S. T. Hansen: None. F.K. Knop: Advisory Panel; Self; AstraZeneca, MedImmune, Merck Sharp & Dohme Corp., Mundipharma, Novo Nordisk A/S, Sanofi. Consultant; Self; Amgen Inc., Carmot Therapeutics, Novo Nordisk A/S. Research Support; Self; AstraZeneca, Novo Nordisk A/S. Speaker's Bureau; Self; AstraZeneca, MedImmune, Merck Sharp & Dohme Corp., Mundipharma, Norgine, Novo Nordisk A/S. T. Vilsbøll: None.
984-P: Real-World Adherence and Discontinuation of GLP-1 Receptor Agonist (GLP-1RA) Therapy in Type 2 Diabetes (T2D) Patients in the U.S.
Authors: WEISS TRACEY , IGLAY KRISTY , CARR RICHARD D. , MISHRA AJAY PRATAP , YANG LINGFENG , RAJPATHAK SWAPNIL
Published: June 2019

Background: GLP-1 RAs are an incretin-based, injectable, therapeutic option for the treatment of T2D. However, there are limited data related to patients’ adherence to, or discontinuation of, GLP-1 RA therapy in the real-world.

Methods: Using the Optum Research Database (2010-2016), we conducted a retrospective cohort study of U.S. T2D patients ≥ 18 years initiating GLP-1 RAs as monotherapy or as dual therapy with metformin to evaluate GLP-1 RA adherence and discontinuation. GLP-1 RA adherence was assessed using the proportion of days covered (PDC) among all GLP-1 RA initiators with two or more prescription fills. Discontinuation was defined as any GLP-1 RA therapy gap >90 days after end of days of supply from medication fill during follow-up. Multivariable logistic regression was used to evaluate factors associated with non-adherence and discontinuation.

Results: Of 4,791 patients included, 42% were female and median age was 56 years. The proportion of patients characterized as non-adherent (PDC <80%) was 49.1% within 1 year. The proportion of patients who discontinued therapy was 47.7% within 1 year. Factors associated with poor adherence/discontinuation within 1 year included male sex, older age, Southern geographic region, and Medicare insurance.

Conclusion: A substantial proportion of U.S. T2D patients are non-adherent to GLP-1 RA therapy and nearly half of patients discontinue GLP-1 RA therapy within a year. Further investigation on the impact of adherence on real-world effectiveness, including weight loss and HbA1c, is warranted.

Disclosure

T. Weiss: Employee; Self; Merck & Co., Inc. K. Iglay: Employee; Self; Merck & Co., Inc. Stock/Shareholder; Self; Merck & Co., Inc. R.D. Carr: Employee; Self; Merck & Co., Inc. Speaker's Bureau; Spouse/Partner; Eli Lilly and Company, Merck & Co., Inc. A.P. Mishra: None. L. Yang: Employee; Self; Bristol-Myers Squibb Company, Merck & Co., Inc. S. Rajpathak: None.
99-LB: Meta-analysis of Three Real-World, Chart Review Studies to Determine the Effectiveness of FreeStyle Libre Flash Glucose Monitoring System on HbA1c in Adults with Type 2 Diabetes
Authors: KROEGER JENS , FASCHING PETER , HANAIRE HELENE
Published: June 2019

Three retrospective chart review studies evaluated the effectiveness of the FreeStyle Libre Flash Glucose Monitoring SystemTM on HbA1c when used by adults with type 2 diabetes (T2DM) as their standard of care in a real-world setting. Each study aimed to determine the effect of FreeStyle Libre when used for between 3 months to 6 months on HbA1c. Each study population included adults on a basal-bolus insulin regimen for at least 1 year who had been using FreeStyle Libre regularly for at least 3 months (either self-funded or prescribed) and with HbA1c between 8.0 and 12.0% (64 to 108 mmol/mol). Pregnant patients were excluded, as were patients on dialysis. This meta-analysis comprised of a total of 363 records from insulin using patients with T2DM from 18 medical centres in Austria, France and Germany. On average, HbA1c was 8.9±0.9% (73.3±9.8 mmol/mol) prior to FreeStyle Libre use, age was 63.5±11.0 years and average duration of insulin use 8.3±5.8 years (mean±SD), 67.8% of patients were on oral antidiabetic medications (metformin, SU, TZD, DPP-4 or SGLT2) and 56.4% were male. CVD, renal and retinopathy complications were reported by 36.4%, 33.9% and 19.6% of patients, respectively. HbA1c results were recorded between 90 and 194 days from the start of use of FreeStyle Libre, between January 2015 and August 2018. Overall mean change in HbA1c, after at least 3 months of using FreeStyle Libre, was significantly reduced by 0.9±0.05% (mean±SE); p<0.0001, with no heterogeneity between countries (Q=0.7, I2=0, p=0.7113). No significant differences were detected between: age group, sex, BMI or duration of insulin use. This meta-analysis of three real-world, chart review studies concludes that people with T2DM on insulin therapy, using FreeStyle Libre for between 3 to 6 months significantly reduced HbA1c.

Disclosure

J. Kroeger: Board Member; Self; Abbott. Consultant; Self; Abbott. P. Fasching: None. H. Hanaire: Research Support; Self; Abbott, Eli Lilly and Company, LifeScan, Inc., Novo Nordisk A/S. Other Relationship; Self; Eli Lilly and Company, Novo Nordisk A/S.
990-P: Therapeutic Effect of a Novel Long-Acting GLP-1/GIP/Glucagon Triple Agonist (HM15211) in a NASH and Fibrosis Animal Model
Authors: KIM JUNG KUK , LEE JONG SUK , KIM DAEJIN , PARK EUNJIN , KIM YOUNG HOON , CHOI IN YOUNG
Published: June 2019

NASH, a severe form of NAFLD, can lead to end stage liver disease such as cirrhosis. Despite increasing prevalence and as a burden for public health, advances in the development of therapeutics are slow with yet no approved drug for NASH treatment. Since liver fat accumulation and inflammation are associated with NASH progression, targeting both aspects may contribute to NASH resolution and fibrosis improvement. Thus, to directly aid those aspects, we developed a novel long-acting, GLP-1/GIP/Glucagon triple agonist, HM15211. With a unique activity profile, HM15211 showed a liver preferential distribution, and exerted potent hepatic triglyceride (TG) reduction in addition to efficient weight loss in DIO mice, suggesting HM15211 as a novel therapeutic option for NASH treatment. Here, we evaluated the therapeutic potential of HM15211 in NASH and fibrosis animal models including monkeys. In MCD-diet mice (6 weeks induction), HM15211 led to significant decrease in hepatic TG content (-82.6% vs. vehicle), which coincided with reduction of elevated ALT and bilirubin. Time course MRI confirmed the progressive resolution of steatosis. Histological analysis also indicated a significant reduction both in hepatic inflammatory gene expression and NAFLD activity score (1.3 for HM15211, 3.4 for liraglutide, and 2.7 for vehicle). To further evaluate the therapeutic potential in fibrosis, MCD-diet mice were used for an extended period (up to 12 weeks induction) for overt liver fibrosis induction. In line with NASH improvement, HM15211 reduced hepatic hydroxyproline and the fibrosis score markedly. Finally, obese and NASH monkeys were administered with HM15211, and efficient weight loss, improvement of lipotoxicity and improvement of histological NASH/fibrosis markers were confirmed in primates too. Based on these results, HM15211 may provide efficacy for the treatment of NASH and fibrosis. Further studies are needed to assess the clinical relevance of these findings.

Disclosure

J. Kim: None. J. Lee: None. D. Kim: None. E. Park: None. Y. Kim: None. I. Choi: Employee; Self; Hanmi Pharm. Co., Ltd.
995-P: Semaglutide in Patients with Type 2 Diabetes: Real-World Analysis in the Canadian LMC Diabetes Registry: The SPARE Study
Authors: BROWN RUTH E. , LIU AIDEN R. , MAHBUBANI REENA , ARONSON RONNIE
Published: June 2019

The Canadian LMC Diabetes Registry will evaluate real-world clinical outcomes in GLP-1 RA naïve patients with T2D who initiate once weekly semaglutide as part of their usual diabetes therapy in the first year of semaglutide availability in Canada. Primary outcome is change in A1C at 3 - 6 months follow-up. In this interim retrospective analysis of the first six months of semaglutide availability, 542 patients who initiated semaglutide were eligible (37% on 1.0 mg dose and 63% on 0.5 mg dose). They had a mean age of 57.3 ± 10.1 years, T2D duration of 12.0 ± 7.4 years, and baseline A1C of 8.23 ± 1.34%. At 3-6 months follow-up, 466 patients who remained on-treatment showed an A1C reduction of 0.88 ± 1.15% (p<0.01), with 36% of patients achieving an A1C reduction ≥1.0% and 43% of patients achieving A1C ≤7.0%. Similar benefit in A1C lowering was seen in subgroups based on prior diabetes therapy, concomitant insulin use and prior use of DPP-4i (Figure). Mean weight reduction was 3.1 ± 3.6 kg and 23.6% of patients achieved a weight loss ≥ 5%. Reductions were also seen for systolic BP (5.1 ± 13.0 mmHg, p<0.01), diastolic BP (2.2 ± 9.3 mmHg, p<0.01) and alanine aminotransferase (1.7 ± 12.9 U/L, p=0.03). In this real-world analysis of a large Canadian cohort, patients initiating semaglutide had significant reductions in A1C and weight at three to six months, regardless of prior and concomitant diabetes therapy.

Disclosure

R.E. Brown: None. A.R. Liu: Employee; Self; Novo Nordisk A/S. R. Mahbubani: Employee; Self; Novo Nordisk Inc. R. Aronson: Research Support; Self; AstraZeneca, Becton, Dickinson and Company, Boehringer Ingelheim Pharmaceuticals, Inc., Eli Lilly and Company, Janssen Pharmaceuticals, Inc., Medtronic, Merck & Co., Inc., Novo Nordisk Inc., Sanofi, Senseonics.

Funding

Novo Nordisk Canada Inc.
Abnormal Cortical and Trabecular Bone in Youth With Type 1 Diabetes and Celiac Disease
Authors: Pham-Short Anna , Donaghue Kim C. , Ambler Geoffrey , Briody Julie , Garnett Sarah , Munns Craig F. , Craig Maria E.
Published: June 2019

OBJECTIVE

This study compared bone health in youth with type 1 diabetes and celiac disease (CD) versus type 1 diabetes alone.

RESEARCH DESIGN AND METHODS

This was a case-control study of 42 youth with coexisting type 1 diabetes and CD and 40 with type 1 diabetes matched for age, sex, diabetes duration, and HbA1c. Bone mineral density (BMD), bone mineral content (BMC), and BMC-to-lean tissue mass (LTM) ratio were measured using DXA and reported as z-scores for height. Total, trabecular, and cortical bone and muscle parameters were measured using peripheral quantitative computed tomography (pQCT) and reported as z-scores for age.

RESULTS

Mean age at assessment was 14.3 ± 3.1 years; diabetes duration, 8.0 ± 3.5 years; HbA1c, 8.2 ± 1.5% (66 ± 5 mmol/mol); and 25-hydroxy vitamin D, 71 ± 21 nmol/L. Comparing youth with coexisting CD versus type 1 diabetes alone, DXA showed lower BMC-to-LTM ratio (0.37 ± 1.12 vs. 0.73 ± 2.23, P = 0.007) but no difference in total BMD. Youth with coexisting CD also had lower BMC-to-LTM ratio versus the general population (P = 0.04). Radial pQCT showed lower total BMC (−0.92 ± 1.40 vs. −0.26 ± 1.23, P = 0.03) despite similar bone and muscle cross-sectional area. In multivariable linear regression, lower BMC was associated with higher insulin dose (P = 0.03) but not HbA1c.

CONCLUSIONS

Youth with both type 1 diabetes and CD have lower BMC relative to LTM and lower BMC, indicating abnormal trabecular and cortical bone development despite similar bone and muscle size. These findings suggest that the two conditions confer a lower bone turnover state. We recommend further examination of bone health in this population; future research should examine early interventions to improve bone health.
Tilnærminger i forskning om samordning og samarbeid
Authors: Andreassen Tone Alm
Published: June 2019

Dette kapitlet presenterer tre forskningstilnærminger til samordning og samhandling – henholdsvis forskningen om integrerte tjenester, om nettverksstyring og om interorganisatorisk samarbeid og organisatoriske nettverk. Disse tilnærmingene har sine viktigste forankringer i henholdsvis helsetjenesteforskningen, forvaltningsforskningen og organisasjonsforskningen. Framstillingen legger hovedvekten på hva forskningstilnærmingene har vært opptatt av, ikke hva forskningen forteller om hvorvidt samordning og samarbeid fungerer og leder til ønskede resultater. Kapitlet bygger primært på litteratur som søker å sammenfatte og systematisere de ulike tilnærmingene.

Hensikten er å vise at en i forskningen kan nærme seg spørsmål om samordning og samarbeid på tvers av fag, profesjoner, organisasjoner og sektorer med ulike forskningsinteresser, begreper og teoretiske perspektiver. Denne variasjonen representerer en ressurs i empiriske studier. De tre tilnærmingene retter oppmerksomheten mot ulike typer organisasjoner samt motivasjon for samordning og samhandling på tvers. De kan derfor kan utfylle hverandre i analyser av samordning og samarbeid i helse- og velferdstjenestenes organisasjoner.
Tverrprofesjonelt samarbeid i ulike styringskontekster – hverdagsrehabilitering som eksempel
Authors: Vabø Mia
Published: June 2019

Tverrfaglighet og tverrprofesjonelt samarbeid er blitt et mantra i helse- og omsorgstjenestene. Bak begrepene skjuler det seg imidlertid varierende praksiser. Det varierer hvem som samarbeider, om hva, i hvilken fase av tjenesteforløpet og ut fra hvilken hensikt. Med eksempler fra hverdagsrehabilitering i to kommuner viser jeg hvordan slike variasjoner henger sammen med ulike styringskrav og styringssystemer. Jeg viser hvordan en likelydende idé om et tverrfaglig samarbeid ble fortolket i lys av kommunenes ulike styringsambisjoner, og hvordan omfanget og formen for samarbeid ble preget av ulike forvaltningsstrukturer, ulik tildelingspraksis og ulik tiltro til faglig skjønn. Med henvisning til disse ulikhetene argumenterer jeg for at det på ingen måte er entydig og gitt hva et tverrprofesjonelt samarbeid innebærer. Det er heller ikke gitt at det er noe selvinnlysende fordelaktig. En må alltid reise spørsmål ved hvilken hensikt det tverrprofesjonelle samarbeidet skal tjene, og for hvem det eventuelt vil være en fordel.
Tverrfaglige team – hvordan lykkes?
Authors: Ramsdal Helge
Published: June 2019

I dette kapittelet gjennomgås noen perspektiver på teamorganisering i helse- og velferdssektoren. Spørsmålet er hvordan team kan bli effektive når det gjelder mål og oppgaver. Med utgangspunkt i en analysemodell der ulike aspekter ved teamorganisering blir sett i sammenheng, drøfter jeg tre empiriske studier som belyser forhold som hemmer og fremmer effektivt arbeid i team. Denne drøftingen er basert på studier av tverrfaglige team fra henholdsvis arbeids- og velferdsetaten, lokalbaserte tjenester for mennesker med rusproblemer og psykiske lidelser, og et overvektsteam ved et sykehus. Innenfor rammen av den analysemodellen som er presentert, er det to forhold som fremheves som avgjørende for om teamene har lykkes i sine intensjoner: For det første kontekst, det vil si kjennetegn ved de delene av helse- og velferdssektoren teamene arbeider innenfor. Hvordan team kan inngå i det tjenestesystemet de er en del av, har stor betydning. For det andre er også teammedlemmenes tilknytningsform som heltids- eller deltidsdeltakere i teamet viktig. Vi ser på betydningen av å foreta en kritisk vurdering av den sammenhengen etableringen av nye team inngår i, og at en er bevisst på ulike utfordringer som vil kunne møte teamene – avhengig av hvilke organisatoriske løsninger en velger.
Digitalisering – løsninger og problemer
Authors: Bjørkquist Catharina
Published: June 2019

Dette kapitlet diskuterer muligheter og utfordringer for samordning når helse- og velferdstjenester digitaliseres. Spørsmålet om hvilke utfordringer digitaliseringen er tenkt å løse, analyseres gjennom en studie av nasjonale policydokumenter. Spørsmålet om hvordan digitalisering påvirker samordning av helse- og velferdstjenester, besvares gjennom en litteraturstudie hvor tidligere forskning drøftes. Den offentlige politikkens begrunnelser for digitalisering legger vekt på effektivisering og frigjøring av ressurser. Digitale fagsystemer kan hindre kommunikasjon og informasjonsflyt blant annet fordi informasjonen ikke er oppdatert, eller fordi ansatte mangler tilgang. IKT-systemer bidrar til å etablere felles faglige rammer, men skaper også mindre profesjonelt handlingsrom. Tjenesteytere finner ulike måter å gjøre motstand mot de digitale systemene på. I noen sammenhenger gir de uttrykk for at de bruker for mye tid på skjerm, tid som kunne vært anvendt med bruker. Slike forhold kan skape utfordringer med å samordne tjenester. Digitale løsninger bidrar i seg selv ikke til å løse eksisterende samordningsproblemer.
KEBANGKRUTAN LEMBAGA PERKREDITAN DESA (LPD) BERDASARKAN ANALISIS BERBAGAI FAKTOR
Authors: Saputra Komang Adi Kurniawan , Trisnadewi A.A. Ayu Erna , Anggiriawan Putu Budi , Kawisana Putu Gede Wisnu Permana
Published: June 2019

This study aims to examine several factors that influence the bankruptcy of LPDs in Buleleng Regency, the factors in question are legal protection, managerial competence, good corporate governance, the active role of citizens and the role of internal supervisory bodies. In this study using a questionnaire method with 63 respondents namely LPD managers and for data analysis use multiple regression analysis. The results of this study state that only the manager's competence and the role of internal supervisory bodies have an influence on the potential of LPD bankruptcy, while legal protection variables, good corporate governance and the active role of citizens do not affect the potential for bankruptcy LPD in Buleleng Regency.
The Effect Of Discovery Learning – Based Teaching Material By Utilizing Traditional Game On Mathematic Abilities Of The 2nd Graders Of Elementary School
Authors: Isnardiantini Sam , Usodo Budi , Soegiyan H.
Published: June 2019

The objective of research was to find out the effect of discovery learning-based mathematic teaching
learning by utilizing traditional games on utilizing traditional game on multiplying and dividing
abilities of the 2nd graders of SD Negeri Badran and SD Negeri (Public Elementary School No.02 of
Kerten). This study was an experimental quantitative research. The subject of research was the 2nd
graders of Public Elementary Schools in Surakarta in the school year of 2017/2018. The result of the
limited try out of instructional materials gets the average of 79,51%. The result of the instructional
materials wide material’ test has the average of 82,94% . The result of research showed tstatstic of
2.490 >2 t table = 1,997 for experiment group at significance level of 0.5%, so that there is a significant
improvement. Thus, discovery learning based-mathematic teaching material utilizing traditional
games can improve the students’ multiplying and dividing abilities significantly
EVOLUTION OF SURGICAL TACTICS AT THE ACUTE APPENDICITIS
Authors: Gavshchuk M. V. , Gostimsky A. V. , Barsukova I. M. , Naidenov A. A. , Carpatsky I. V. , Shudaev I. R.
Published: June 2019

The problem of diagnostics and treatment of an acute appendicitis remains extremely actual and are of spe­cial interest for system of rendering an emergency medical service as it is connected with delivery of health care in the emergency form. The assessment of evolution of surgical tactics at an acute appendicitis was a research objective. The content analysis, legal, historical, analytical, statistical methods are used. Data of the monitor­ing of sharp surgical pathology of abdominal organs in St. Petersburg which is carried out by the St. Petersburg Scientific Research Institute of Emergency Medicine of I. I. Dzhanelidze, normative legal documents, domestic and foreign scientific literature became material for research. Medical and diagnostic tactics at an acute appendi­citis I evolved from conservative to active (quick) which dominates and now. Today it comes back to possibility of conservative treatment of its uncomplicated forms again. The stationary office of an emergency medical service allows to change routing of patients with an acute appendicitis, to provide possibility of inspection and dynamic supervision of patients within the first days from the beginning of a disease from the beginning of starting conser­vative therapy (single introduction of glucocorticoids and antibiotics).
O DIREITO HUMANO A EDUCAÇÃO NA CF/88 E O DESENVOLVIMENTO: ABORDAGEM JURÍDICO REFLEXIVA A PARTIR DE DESENVOLVIMENTO EM AMARTYA SEN
Authors: Mallmann Liana Zerbielli Trentin , Zambam Neuro José
Published: June 2019

O objetivo desta abordagem é fundamentar o direito humano à educação na CF 88 a partir das categorias de Amartya Sen como condição irrenunciável para o desenvolvimento humano, social e sustentável. Esta pesquisa de matriz indutiva e bibliográfica demonstra que a educação com qualidade é responsável pela remoção das principais privações de liberdades e pela promoção das capacitações (capabilities). Conclui-se que a promoção do direito a educação impulsiona o exercício das liberdade e capacidades dos sujeitos e consequentemente, promove o desenvolvimento humano, social e sustentável
L’ARTICULATION DE LA JURIDICTION SPÉCIALE POUR LA PAIX AVEC LA JUSTICE ORDINAIRE EN MATIÈRE D’EXTRADITION : LES ENJEUX POLITIQUES DU CAS JESUS SANTRICH DANS LE CONTEXTE DU POST-CONFLIT COLOMBIEN
Authors: Calderón-Valencia Felipe , Escobar-Sierra Manuela
Published: June 2019

L’objectif général de cet article est d’analyser deux cas de conflit de compétence entre l’ordre de juridiction ordinaire et la Juridiction spéciale pour la paix (JEP) en Colombie. Les ordonnances de la Cour constitutionnelle qui tranchent l’affaire offrent des réponses différentes et complémentaires à la demande d’extradition de l’ancien chef de la guérilla des FARC-EP, Seuxis Paucias Hernández Solarte, connu sous l’alias de Jésus Santrich. Le « cas Santrich » permet donc une analyse constitutionnelle de la pratique de l’extradition dans un contexte de post-conflit dans un pays très complexe, tant du point de vue juridico-institutionnel que politique. Finalement, cette analyse nous permet de conclure que le « cas Santrich » montre comment le déroulement d’une procédure d’extradition peut affecter ou porte atteinte à l’avenir de la terminaison effective du conflit, ayant une durée de plus de 50 ans.
A HIERARQUIA DOS TRATADOS INTERNACIONAIS E SEUS REFLEXOS JURÍDICOS E EXTRAJURÍDICOS
Authors: Rocha Floriani Lara Bonemer , Santos Luccas Farias
Published: June 2019

Este trabalho se propõe à análise da posição dos tratados internacionais na hierarquia das normas jurídicas, buscando avaliar se possuem o mesmo nível hierárquico das leis, ou se são hierarquicamente superiores, bem como os reflexos jurídicos e extrajurídicos advindos desta colocação. Para atingir este objetivo, faz-se necessário o estudo dos tratados internacionais, sua forma de incorporação e vigência no ordenamento jurídico brasileiro, bem como sua relação com as demais normas jurídicas. O método científico utilizado para o desenvolvimento da pesquisa foi o teórico/dedutivo. Ademais, como técnicas de pesquisa, foram utilizados textos normativos e, sobretudo, doutrina especializada. A primeira parte do artigo é dedicada à nomenclatura das normas de direito internacional, com a finalidade de identificar qual a nomenclatura adequada para os fins deste estudo. Na sequência, é analisado o procedimento de celebração dos tratados internacionais e quais as consequências advindas desta prática, especialmente no tocante ao momento de entrada em vigor nos Estados-Partes. Assentadas estas premissas, passa-se à análise da questão afeta à hierarquia normativa dos tratados internacionais perante o ordenamento jurídico interno, com fundamento nas teorias que tratam do assunto, em confronto com a jurisprudência. Ao final, são tecidas considerações acerca da importância do tema em discussão não somente sob uma perspectiva jurídica, como também, nas relações políticas entre países e na afetação econômica decorrente.
A VIOLÊNCIA ESTRUTURAL E A MARGINALIZAÇÃO DAS CLASSES SUBALTERNIZADAS NO PROCESSO DE CRIAÇÃO E APLICAÇÃO DAS LEIS PENAIS BRASILEIRAS
Authors: Wermuth Maiquel Ângelo Dezordi , Campos Paula Bohn de
Published: June 2019

O artigo analisa as atuações e posições dos sujeitos pertencentes às classes subalternizadas com relação ao sistema penal brasileiro. O texto parte do seguinte problema de pesquisa: em que medida a violência estrutural e a marginalização das classes subalternizadas, no Brasil, as afasta dos processos de criação e aplicação das leis penais, transformando-as, consequentemente, em destinatárias principais das medidas punitivas? O artigo encontra-se estruturado em três seções que correspondem, respetivamente, aos seus objetivos específicos. Na primeira seção, busca-se analisar como a produção legislativa na seara penal encontra-se condicionada por fatores relacionados às demandas das classes que ocupam, na estrutura de classes brasileira, espaços privilegiados de poder, demandando a constante criminalização dos setores subalternizados. Na segunda seção, o artigo analisa como a criação de leis voltadas aos setores subalternizados impacta a atuação policial sobre esses indivíduos. Por fim, na terceira seção, o artigo visa a demonstrar como o encarceramento, no Brasil, evidencia o fechamento de um ciclo penal pautado pela seletividade. Adotou-se na investigação o método fenomenológico-hermenêutico.
PROCESSO DE TRABALHO NA ESTRATÉGIA DE SAÚDE DA FAMÍLIA: PERSPECTIVA DOS CIRURGIÕES-DENTISTAS DO DISTRITO FEDERAL
Authors: De Moura Regina Cardoso , Coelho de Souza Tiago Araújo
Published: June 2019

O objetivo deste estudo transversal, descritivo e inferencial foi analisar o processo de trabalho quanto à integralidade em saúde e integração em equipe na perspectiva dos cirurgiões-dentistas da Estratégia de Saúde da Família (ESF). Foi aplicado um questionário eletrônico, com escala para as perguntas variando entre 0 e 10 pontos. Foi utilizada estatística descritiva para apresentação das características da amostra; teste de Pearson para análises associativas; teste t de student para amostras independentes e ANOVA one-way para comparações entre grupos; nível de significância de 5% (p<0,05). No processo de trabalho relacionado à integralidade, o atendimento às urgências odontológicas e o acolhimento à demanda espontânea tiveram as melhores avaliações e a visita domiciliar a menor. No processo de trabalho relacionado à integração com a equipe, o compartilhamento da agenda foi o mais bem avaliado. Correlação positiva fraca entre educação permanente e ações regulares de prevenção (r=0,489; p<0,001), ações regulares de promoção (r=0,468; p<0,001) e atenção integral (r=0,344; p=0,001) foram observadas. Os profissionais que não possuem vínculo à uma equipe da ESF ou que cumprem 20 horas apresentaram avaliações mais baixas em ações de integralidade e integração, impactando negativamente na organização e gestão dos processos de trabalho da saúde bucal na ESF no Distrito Federal.
Aeroplanos
Authors: Orthof Gê
Published: June 2019

Ambos mundos é um relato de imaginação poética, que tem início em uma viagem à Cuba e o encontro com o homônimo hotel. À partir da leitura do livro A invenção de Morel de Adolfo Bioy Casares, em uma praia deserta, o processo de ideação em artifício é posteriormente encarnado na elaboração de uma instalação, acompanhado da reflexão sobre os processos de criação em artes, seus múltiplos desvios e a potência dos processos utópicos enquanto uma possível ponte nessa tênue linha de horizonte entre o lá e o cá.
A iconografia dos seres feéricos
Authors: Souza Gustavo Lopes de
Published: June 2019

Este artigo discute os modelos e as transformações da iconografia dos seres feéricos entre a Baixa Idade Média e o século XX.  Partindo-se de uma breve exposição das principais concepções sobre esses seres na cultura medieval, e discutindo-se então suas transformações subseqüentes, busca-se determinar, aproximativamente, quando e de que modo lhes foram atribuídas seus elementos iconográficos mais característicos, discutindo-se o papel que tiveram nesse processo a iconografia clássica e o medievalismo romântico.
Ensino de arte e educação emancipatória face à arte contemporânea
Authors: Hillesheim Giovana Bianca Darolt
Published: June 2019

No intuito de desmascarar uma falsa incompatibilidade entre arte contemporânea e educação emancipatória, este estudo apresenta uma reflexão sobre os enfrentamentos conceituais necessários ao abordar a arte contemporânea no ensino de arte escolar. Para tanto, parte-se de uma descrição do entrelaçamento entre arte e mercado, considerando as nuances pós-modernistas desta relação. A sustentação do construto teórico se dá por meio do materialismo histórico-dialético, com ênfase em Terry Eagleton e Antonio Gramsci, na medida em que estes destacam a importância do pensamento histórico no processo de emancipação humana. A ascensão da mercadoria arte a partir dos anos 1970 e a privatização da cultura iniciada nos anos 80 são investigadas como dimensões importantes no redirecionamento do papel da arte e do artista na atualidade.
La Biblioteca de Babel - uma conversa com Eduardo Viveiros de Castro e Déborah Danowski
Authors: Sommer Michelle Farias , Mangrané Daniel Steegmann
Published: June 2019

Inspirado no conto do escritor argentino Jorge Luis Borges, de 1944, nomeamos esse encontro, realizado em um fim de tarde de verão de 2014, no Rio de Janeiro. Em formato discussão livre, quatro vozes polifônicas sobrepõem práticas em antropologia, filosofia, artes e curadoria, para discutir o fim do mundo, esse tema aparentemente interminável, “pelo menos, é claro, até que ele aconteça”. O contexto dessa discussão deriva-se  do “Colóquio Internacional: Os Mil Nomes de Gaia: Do Antropoceno à Idade da Terra”, concebido por Bruno Latour, Déborah Danowski e Eduardo Viveiros de Castro, ocorrido em setembro de 2014, concomitante ao lançamento do livro Há um mundo por vir? Ensaio sobre os Medos e os Fins, de Déborah Danowki e Eduardo Viveiros de Castro.A partir da oportunidade de troca generosa dos ensinamentos de Déborah e Eduardo – a quem Claude Lévi-Strauss, seu colega e mentor, definiria como o fundador de uma nova escola na antropologia – compartilhamos aqui os pensamentos daqueles que consideramos os mais inovadores pensadores brasileiros. Entre os narradores dessa experiência de aprendizado (entre os muitos “bibliotecários” possíveis), sugerimos como start point para esse encontro a exploração do tema do fim do mundo pela cultura contemporânea. Aqui, especulamos sobre alguma esperança acerca da perenidade da espécie e sua capacidade de superação, entre fantasias de colonização espacial e avanços tecnológicos utópicos; discutimos sobre o Antropoceno em um contexto midiático a partir da apropriação recente do termo pelas artes e um possível transbordamento teórico do conceito de “perspectivismo ameríndio” (Viveiros de Castro, 1996) para a arte, o que, em última instância encerraria uma dicotomia cara ao nosso campo: a distinção entre obra de arte (observada) e espectador (observador).Enquanto esperamos a vinda de um “messias termodinâmico”, supomos que Maiakovski sorriria orgulhoso da nossa tentativa de manutenção de um “pessimismo alegre” frente ao fim do mundo. Se para o poeta russo é melhor morrer de vodka do que de tédio, substituamos a vodka pela cachaça para uma conclusão possível (ao menos por agora): é melhor morrer de cachaça do que de spray de agrotóxico plantando sementes da Monsanto.
Apresentação
Authors: Couto Maria de Fátima Morethy
Published: June 2019

Estratégias de circulação: artistas, obras e imagens entre trânsitos e intercâmbios
Afiches del Mayo Francés. Gráfica, autoría y alteridad sudamericana en 1968
Authors: Plante Isabel
Published: June 2019

Dada su relación con el Mayo francés, el Atelier Populaire constituye uno de los episodios más citado en relación a los cruces entre arte y política de los años sesenta. Sin embargo, tratándose de un episodio europeo, resulta significativa la centralidad que ciertos artistas sudamericanos tuvieron en la producción de esos afiches. Este artículo analiza la tensión entre los carteles firmados y aquellos producidos de manera anónima. En el contexto de la crisis que mayo del ’68 significó para el campo artístico y su autonomía, se interpreta esa participación en términos de una alteridad que el tercermundismo identificaba con la producción cultural colectiva y politizada.
Território contaminado – impureza e mistura em conexões artísticas entre África e Brasil
Authors: Conduru Roberto
Published: June 2019

O texto aborda a articulação de dimensões ocidentais e não ocidentais da arte produzida no Brasil desde o século XVI até o presente, focando em alguns processos, instituições, artistas e obras marcados por conexões entre Brasil e África: a espacialidade dos quilombos a partir de sua cartografia; as joias de crioulas; a arquitetura construída por mecardores de escravos e ex-escravos na região do golfo do Benim; a arte produzida nas e para as comunidades religiosas afro-brasileiras, com destaque para a obra de Deoscóredes Maximiliano dos Santos, o Mestre Didi.
Co-circulation of dengue, chikungunya, and Zika viruses in Colombia from 2008 to 2018
Authors: Rico-Mendoza Alejandro , Porras-Ramírez Alexandra , Chang Aileen , Encinales Liliana , Lynch Rebecca
Published: June 2019

Objective. This study aimed to identify the co-circulation patterns of three viruses (dengue, Zika, and ­chikungunya) in Colombia from 2008 to 2018 by using notification reports provided to the national surveillance system.

Methods. This cross-sectional study was conducted through a review of data for 2008 through 2018 from Colombia’s Public Health Surveillance System (SIVIGILA).

Results. In 2015, when chikungunya was first detected, it had a higher incidence (1 359.0 cases per 100 000 persons) than did the two other diseases. In 2016, when the circulation of Zika virus was first found, the incidence was 296.4 cases per 100 000 persons; that incidence declined dramatically in the next two years. Between 2015 and 2018, there was a substantial decrease in the frequency of dengue circulation, with it going from 334.1 cases per 100 000 persons in 2015 to 90.7 cases per 100 000 in 2017 and 173.1 cases per 100 000 in 2018.

Conclusions. The decrease in the number of dengue cases after co-circulation of the three viruses could indicate possible cross-protection. This finding should be further analyzed.
Atsolorra, euskal jaiotza-erritua. Ereñotzun jasotakotestigantzak
Authors: Lekuona Antzizar Idurre
Published: June 2019

Atsolorra garai batean Euskal Herrian egiten zen jaiotz-erritua da. Urteen poderioz atsolorra (ia) galdu egin da bazter guztietan. Egun zenbait herritan erritu hori berreskuratzeko ahaleginetan dabiltza. Atsolorra esaten zitzaion haurra jaiotako baserrira igande arratsaldean auzoko emakumeek egiten zuten bisitari. Gehienetan emakumeak besterik ez ziren joaten eta laguntza txiki bat eramaten zuten. Etxekoek esker onez afari-merienda ematen zieten bisitariei.Hernaniko Ereñotzu entitate txikian atsolorra berreskuratu dute. Horretarako, besteak beste, ikerketa-lan txiki bat egin zen 2015. eta 2016. urteetan auzoan, atsolorraren nondik norakoak hobeto ezagutzeko. Horretarako dokumentazio-lana eta landa-lana egin ziren eta bi iturri horietatik jasotako informazioarekin osatua da artikulu hau.Atsolorraz gain, jaiotzaren inguruko bestelako igarobide-errituez, emakumeez eta horien sozializazioaz, gizarte komunitarioaz eta nekaritza-munduaz ere hitz egingo dugu artikulu honetan.
Bemerkungen zur andauernden Aktualität des Werks von Ulrich Engel
Authors: Lobin Henning
Published: June 2019

Ulrich Engel hat mit seinen Publikationen zur deutschen Grammatik, zur Verbvalenz und zur kontrastiven Linguistik große Wirkung auf die internationale germanistische Linguistik ausgeübt. Weniger bekannt ist, dass er mit seinem Werk auch andere linguistische Teildisziplinen beeinflusst hat, die davon bis heute profitieren. Dependenzielle Ansätze spielen bei der maschinellen Syntaxanalyse mittlerweile eine zentrale Rolle, und bei der Entwicklung von Systemen zur maschinellen Übersetzung haben Engels Arbeiten ebenfalls ihre Spur hinterlassen. Der Aufbau von Sprachressourcen in Gestalt von „Baumbanken“ kann auf Engels Grammatikkonzeption zurückgreifen, und auch zur neuerlich florierenden Konstruktionsgrammatik bestehen klare Bezüge. Im Beitrag werden diese weniger bekannten Einwirkungen von Engels Werk in andere Bereiche dargestellt und in ihrer andauernden Aktualität gewürdigt.
Valenz und Afinitheit
Authors: Kotin Michail L.
Published: June 2019

Auf den ersten Blick scheinen beide Titelbegriffe kontradiktorisch zu sein, setzt ja die klassische verbozentrische Valenztheorie, deren Anhänger auch der Geehrte ist, eine weit verstandene „Verbalität“ als konstitutives inhaltlich‑propositionales Satzkriterium voraus, wobei die Finitheit von den meisten deutschen Grammatikforschern zum unveräußerlichen formalen Satzkriterium erklärt wird. So gelten z.B. sämtliche infinite Prädikationen schlechtweg als kommunikative Minimaläußerungen, doch wird ihnen der „normale“ Satzstatus abgesprochen (vgl. Zifonun et al. 1997). Auf der anderen Seite gibt es in vielen Sprachen (so in der Slavia, aber auch in älteren germanischen Sprachen, im Griechischen, zum Teil im Latein) viele vollwertige Satzstrukturen, die formal infinit sind. Auch in der deutschen Gegenwartssprache sind mehrfach satzartige Konstruktionen mit vollprädikativem Inhaltswert, dabei aber ohne finites Verb vorhanden. Viele davon fallen unter den Begriff der Afinitheit (vgl. u.a. Riecke 2012, Kotin 2014), vgl. Was vergangen, kehrt in der gleichen Gestalt nie wieder. Wird bei der Deskription der Valenzstruktur derartiger Sätze oder satzartiger Äußerungen das klassische (Engel’sche) Valenzmodell angewandt, so ergibt dies keine rasanten Unterschiede bei finiten und afiniten Satzsyntagmen, da finite Auxiliare und Kopulae darin grundsätzlich als nicht valenzfähig behandelt werden. Schwieriger wird es allerdings, wenn angenommen wird, dass Kopulae und Auxiliare zumindest eine strukturelle Valenz besitzen und Regentia bezüglich der hierarchisch niedrigeren Vollverben darstellen (vgl. Eroms 2000). In diesem Fall sollen afinite Sätze als Ellipsen eingeordnet und entsprechend syntaktisch behandelt werden. Dieses recht komplizierte und komplexe theoretische Problem der Dependenzgrammatik wird am Beispiel verschiedener Sprachen und unterschiedlicher Entwicklungsstufen, also aus synchroner, kontrastiv‑typologischer und diachroner Sicht betrachtet.
Taxierende Attribute
Authors: Kürschner Wilfried
Published: June 2019

Im folgenden Beitrag wird auf eine bestimmte Sorte adjektivischer Attribute aufmerksam gemacht. Się treten im Strukturschema „Adjektiv + Numerale + Substantiv (Maßangabe/Zählgröße)“ auf. Mit ihnen gibt der Sprecher dem Hörer vor, wie er den angesprochenen Sachverhalt auf einer Skala von „niedrig“ bis „hoch“, „wenig“ bis „viel“ oder dergleichen eingeschätzt, taxiert sehen möchte. Neben solchen skalaren Attributen weisen andere Belege übliche beschreibende Attribute auf. Die Belegsammlung, alphabetisch geordnet nach den vorkommenden Adjektiven, findet sich im Anhang.
Feeding soils: nutrient balance in the northeast of the Iberian Peninsula c. 1920
Authors: Galán del Castillo Elena
Published: June 2019

Understanding the replacement of soil nutrients removed by harvests provides insight into human influence on land fertility. The nitrogen (N), phosphorus (P) and potassium (K) content of cropland in the province of Barcelona circa 1920 was examined with the aim of improving the methodology from a previous study of cropland nutrient balance circa 1860 in a municipality located in the same province. The main fertilization differences between the two studies involve the use of more manure per hectare circa 1920 and the occurrence of more N fixation due to leguminous crops. Though slightly negative for K, the data generally exhibited a nutrient input/ extraction balance. Also noteworthy is the fact that by the latter date synthetic fertilizers had become available. The methodological limitations that constrain a full comparison of the results of the two studies have been provided. Finally, although we could not disaggregate the data on fertilizer per crop type, the results lead us to consider the relationship between fertility and inequality.
Book reviews - Crítica de libros - Crítica de livros (Historia Agraria, 72)
Authors: Dedieu Jean Pierre , Ongaro Giulio , Dimitriadis Sakis , Vilalta María José , Puig Vallverdú Guillem , Linares Luján Antonio Miguel , Almenar Fernández Luis , Martínez Carrión José Miguel
Published: June 2019

CRÍTICA DE LIBROS / BOOK REVIEWS Francisco García González, Gérard Béaur, Fabrice Boudjaaba (eds.): La Historia rural en España y en Francia (siglos XVI-XIX). Contribuciones para una historia comparada y renovada Jean Pierre Dedieu Paolo Pirillo: Forme e strutture del popolamento nel contado fiorentino. III. Gli insediamenti al tempo del primo catasto (1427- 1429) Giulio Ongaro Evi Karouzou: Les jardins de la Méditerranée. Agriculture et société dans la Grèce du Sud, 1860-1910 Sakis Dimitriadis Javier Martínez Sastre: El paraíso en venta. Desarrollo, etnicidad y ambientalismo en la frontera sur del Yasuní (Amazonía ecuatoriana) María José Vilalta Antoni Gavalda: Fam de pa i de terra. La col•lectivització agraria a Catalunya Guillem Puig Vallverdú Folker Hansen: La economía del cáñamo en la España suroriental. El cultivo, manipulación y transformación del cáñamo en su significado para la estructura social de las vegas. Antonio Miguel Linares Luján Richard Jones y Christopher Dyer: Farmers, Consumers, Innovators. The world of Joan Thirsk Luis Almenar Fernández Vicente Pérez Moreda, David-Sven Reher y Alberto Sanz Gimeno: La conquista de la salud. Mortalidad y modernización en la España contemporánea José Miguel Martínez Carrión
MOBILITY OF CERIUM DIOXIDE NANOPARTICLES IN SOILS AT DIFFERENT EXPOSURE SCENARIOS
Authors: Ermolin M. S. , Fedyunina N. N.
Published: June 2019

Nowadays, widespread application of engineered nanoparticles (ENPs) inevitably leads to their release into the environment. Soils are regarded as the ultimate sink for ENPs. The study on the mobility of ENPs in soils is important in the assessment of potential risks related to their toxicity. The behavior of ENPs depends not only on the parameters of soil, but also on the exposure scenarios, namely, the amount of ENPs trapped in soil. We studied the mobility of cerium dioxide nanoparticles (nCeO2) in soils at different exposure scenarios. The relationship between the mobility of nCeO2and their concentration in the soil within the range 1 – 1000 ìg/g is evaluated. It is shown that the mobility of nCeO2decreases with a decrease in their concentration in the soil and attains the minimum value when the concentration of nCeO2goes below 10 ìg/g. In relative units, only about 0.1 – 0.2% of nCeO2(in aforementioned concentration range) exhibit mobility and can migrate in the soil profile under saturated conditions. The lion’s share of nCeO2(about 99.8%) remains immobile in the soil. Evidently, the vertical transport of nCeO2in soil profile should depend on the volume of released suspensions. In the case of small or moderate wet deposition, nanoparticles will accumulate in upper soil horizons characterized with the highest biological activity and thus can affect the soil inhabitants (plant roots, earthworms, insects, microorganisms, etc.).
Efficient n-to-n Collision Detection for Space Debris using 4D AABB Trees
Authors: Bak Stanley , Hobbs Kerianne
Published: June 2019

Collision detection algorithms are used in aerospace, swarm robotics, automotive, video gaming, dynamics simulation and other domains. As many applications of collision detection run online, timing requirements are imposed on the algorithm runtime: algorithms must, at a minimum, keep up with the passage of time. Even offline reachability computation can be slowed down by the process of safety checking when n is large and the specification is n-to-n collision avoidance. In practice, this places a limit on the number of objects, n, that can be concurrently tracked or verified. In this paper, we present an improved method for efficient object tracking and collision detection, based on a modified version of the axis-aligned bounding-box (AABB) tree data structure. We consider 4D AABB Trees, where a time dimension is added to the usual three space dimensions, in order to enable per-object time steps when checking for collisions in space-time. We evaluate the approach on a space debris collision benchmark, demonstrating efficient checking beyond the full catalog of n = 16848 space objects made public by the U.S. Strategic Command on www.space-track.org.