bluuebunny/crossref_metadata_2025 huggingface dataset:
MENTAL HEALTH AMONG HOSPITAL STAFF DURING THE COVID-19 PANDEMIC IN A THAI UNIVERSITY HOSPITAL
Authors: Wiwattanaworaset Pakawat , Pitanupong Jarurin
Published: April 2022

Objective: This study aimed to evaluate the magnitude of mental health outcomes and its associated factors among hospital staff during the coronavirus disease 2019 (COVID-19) pandemic in a Thai university hospital. Methods: This was a cross-sectional study conducted among hospital staff in a Thai university hospital. Data were collected in May 2020 using online questionnaires, comprising of questions pertaining to demographic, self- perceptions of COVID-19 exposure and prevention, and numeric rating scales for fear of and worry about COVID-19. We also included 3 additional measures, which were Stress Test-5, Generalized Anxiety Disorder-7, and Patient Health Questionnaire-9. Polytomous logistic regression and logistic regression were used to analyse the associated factors. Results: Of the 1592 participants, 1242 (78.0%) were medical staff and 350 (22.0%) were non-medical staff. Most participants (54.1%) perceived that they had a moderate possibility of exposure to COVID-19. However, 57.5% of them perceived themselves as having a high ability to prevent contracting COVID-19. A total of 46.7% and 73.9% showed moderate fear and worry, respectively. Nonetheless, 86.0% and 77.7% of the participants reported mild stress and anxiety, correspondingly. Furthermore, most participants (86.6%) did not have or had minimal depression. Being female, having physical illnesses, and moderate to high self-perception of COVID-19 exposure were determined as risk factors for severe mental health outcomes. Conversely, higher income was a protective factor of severe mental health outcomes. Conclusion: During the COVID-19 pandemic, the mental wellbeing of hospital staff should be of concern. Therefore, evaluating mental health outcomes would be one of all evidence to promote mental wellbeing.
ABSENT SUPRARENAL INFERIOR VENA CAVA REVEALED ON CT SCAN IN A PATIENT WITH ACUTE APPENDICITIS
Authors: Lip Henry Tan Chor , Huei Tan Jih , Kannan Ballan
Published: April 2022

Inferior vena cava agenesis (IVCA) is an uncommon congenital anomaly which was first described in the seventeenth century. The detection of such an anomaly is often incidental and patients are asymptomatic until the third to fourth decade of life. Due to the scarcity of these cases, there is no consensus on the subsequent treatment and surveillance of incidental asymptomatic IVC anomalies. Herein, we report on a young male with incidental findings of suprarenal IVC agenesis identified on contrast enhanced computed tomography (CT) scan of the abdomen in the course of treatment for acute appendicitis.
MASSIVE LIFE-THREATENING SUBCUTANEOUS EMPHYSEMA: A MANIFESTATION OF TRACHEOBRONCHIAL INJURY
Authors: Wong Chui King , Tan Glen Chiang Hong , Jaafar Mohd Johar
Published: April 2022

Subcutaneous emphysema, a known complication of tracheobronchial injury (TBI), is usually a self-limiting condition, but occasionally, a massive one can become life-threatening. We present a patient with TBI who developed massive subcutaneous emphysema with bilateral pneumothorax causing hemodynamic instability. Upon arrival to the hospital, the patient required emergent intubation for impending respiratory collapse. Bilateral thoracostomy tubes were inserted, resulting in hemodynamic improvement. Emergent CT thorax showed a tracheal-oesophageal injury just distal to the cuff of the endotracheal tube (ETT) at the level of the third thoracic vertebra (T3). Despite surgical repair and intensive care, the patient succumbed after a week in ICU due to ventilatory failure. This case report highlights the importance of the initial management of TBI requiring rapid identification and airway management.
OMOHYOID MUSCLE SYNDROME: A CASE REPORT
Authors: Krishinan Jegdiswary , A. Karim Noor Khairiah , Shuaib Ibrahim Lutfi , King Chia Kok , Sapiai Nur Asma
Published: April 2022

Omohyoid muscle syndrome (OMS) is one of the rare causes of lateral neck swelling during swallowing and it is often a worrisome observation due to the concern of malignancy and cosmetic deformity. Anatomical variation, congenital weakness, or trauma may cause incompetence of the fascial-retaining mechanism and subsequently OMS. Its prevalence is unknown as only a few cases were reported in the past and none in Malaysia. Diagnosing OMS is very challenging. Hence, imaging techniques like real time ultrasound or dynamic computed tomography can be useful in assessing the affected muscles.
NEURO-OPTOMETRIC VISION REHABILITATION AFTER PONTINE CAVERNOMA: A CASE REPORT
Authors: Tien Stanley , Yit Ng Chen , Mazlan Mazlina
Published: April 2022

It is common to have vision problems after neurological insults such as traumatic brain injury, stroke or brain tumours. While these neurological insults can affect patients’ daily functioning to different extents, vision problems can be the main obstacle to the dysfunction. A 19-year-old boy with pontine cavernoma presented to the clinic with multiple visual problems at ten months after surgical removal of the tumour. He has left 6th cranial nerve palsy with persistent diplopia and nystagmus. These were associated with giddiness, imbalance, cerebellar impairments, right hemiparesis and hemisensory loss. This case illustrates the importance of adding the neuro-optometric vision rehabilitation, which include visual information processing therapy and other substitutive interventions, into the existing multidisciplinary rehabilitation program to achieve the greatest functional benefit.
THE CONCEPTUAL FRAMEWORK IN IMPROVING ANTI-SMOKING STRATEGIES IN MALAYSIA
Authors: Jaafar Mohamad Helmy , Alias Normalina , Mat Yusof Afzan , Md Isa Muhammad Lokman
Published: April 2022

This paper proposes a conceptual model for establishing a new approach to improvise anti-smoking strategies. The Tobacco Control programme under the World Health Organization (WHO) has established MPOWER measures to be applied globally. Although numerous approaches have been implemented, there is a knowledge gap pertaining to the positive impact of these strategies. Therefore, analyzing current approaches and establishing new strategies will be beneficial for the tobacco control movement. The proposed model has been adapted from the Medical Research Council (MRC), United Kingdom framework for complex interventions which can be used as reference for researchers to develop a new initiative or strategy for tobacco control. This proposed model incorporates three phases, which are (i) Phase 1: To identify factors influencing stop smoking desires and their successfulness among “specific location” population, (ii) Phase 2: To analyse available smoking cessation strategies globally using systematic review, and (iii) Phase 3: To develop new potential tools/products/guidelines for anti-smoking promotions based on Phase 1 and 2. The novelty of this concept in developing anti-smoking strategies is the incorporation of local needs in Phase 1. This research may contribute significantly to stop or quit smoking behavior among Malaysians. At the end of this study, researchers will be able to recommend new and/or adapted tools/products/guidelines based on the framework discussed. Also, government regulations regarding cigarettes should be properly reviewed in order to achieve more significant results whilst minimizing expenses for anti-smoking campaigns.
ENSINO REMOTO E AS TECNOLOGIAS DIGITAIS NA PERSPECTIVA DOCENTE NOS ESPAÇOS URBANO E RURAL
Authors: Lucio Karina de Oliveira , Jorge Ana Maria Barbosa , Pereira Pinho Silva Albina
Published: April 2022

Este texto analisa o processo de ensino em contextos distintos rural e urbano e compreende como os docentes destes ambientes utilizam, no ensino remoto emergencial, as interfaces digitais e os letramentos. Trata-se de um estudo baseado no método qualitativo, com análise de dados gerados por meio de questionários online norteados em Lemos e Barton e Lee, autores que oferecem uma interessante base teórica para os estudos de linguagens e tecnologias. A pesquisa busca corroborar as percepções dos intérpretes sociais no processo do ensino remoto.
ARGUMENTAÇÃO EM VOZES QUE CONSTITUEM O CAMPUS AVANÇADO DA UERN DE PAU DOS FERROS
Authors: Nascimento Mendes Victor Rafael do
Published: April 2022

Este trabalho tem por objetivo analisar a argumentação em discursos que constituem o Campus Avançado da Universidade do Estado do Rio Grande do Norte (UERN) de Pau dos Ferros, tendo como foco a produção de efeitos de sentidos e recursos de presença. Utilizamos como fonte de investigação o Corpus “Vozes”, constituído durante os anos de 2011 a 2014 em pesquisa institucional de iniciação científica, financiada pelo Conselho Nacional de Pesquisa (CNPq), na UERN-Campus Avançado de Pau dos Ferros, Departamento de Letras. O aporte teórico advém das discussões apresentadas na obra tratado da argumentação: a nova retórica (OLBRECHTS-TYTECA; PERELMAN, 1993, 1996, 1999), dos estudos filiados aos estudiosos do tratado (REBOUL, 2004; SOUZA, 2008), da teoria dialógica da linguagem (BAKHTIN, 2003) e dos estudos sobre efeitos de sentido (SOUZA, 2003). A metodologia está situada no caráter descritivo e interpretativo, tendo como base para a análise os estudos teóricos apresentados nessa pesquisa. Para a análise, realizamos um recorte de dois discursos do corpus que ainda não foram analisados, a saber: ex-reitor e ex-professora. Os resultados sugerem que muitos argumentos e efeitos de sentido são revelados nos discursos produzidos, que começam dos fatos e narrativas que fundam a Universidade, da oposição do ontem e hoje, opiniões sobre a qualidade de ensino, administração, até às relações humanas. Por fim, esses sentidos são constituídos a partir dos recursos de presença no discurso, especialmente através das narrativas, pois, como diz Perelman (1993), a narrativa testemunha o efeito de presença.
TERRITÓRIOS E DESTERRITORIALIZAÇÃO NO ROMANCE A MORTE E O METEORO, DE JOCA REINERS TERRON.
Authors: Cruz Lucas , Felippe Renata
Published: April 2022

Este trabalho tem como objeto de análise o romance A Morte e o Meteoro (2019), de Joca Reiners Terron, uma história apocalíptica desenvolvida no território latino-americano. O seu foco de análise está no processo de apagamento das propriedades sociais e culturais de uma sociedade ameríndia fictícia da Amazônia brasileira, os kaajapukugi, ocasionado por um histórico de violências territoriais concretas e simbólicas. A análise parte da compreensão teórica das práticas de desterritorialização na América Latina, das atitudes migratórias da sociedade indígena e das transversalidades culturais presentes no continente-nação. Ao final, contrapõe-se o imaginário mítico da tribo indígena com o dos personagens narradores, percebendo as diferenças entre eles quanto à preservação de uma genealogia identitária.
VIDA E OBRA
Authors: Peloggio Marcelo
Published: April 2022

Este estudo examina a relação entre autor, vida e obra a partir de uma perspectiva teórica integrada na estrutura geral de sua produção literária. No entanto, análises apenas genéticas, biográficas ou psicológicas são investigadas em suas contradições e omissões. O objetivo principal, portanto, é enfatizar a integridade estética do trabalho do autor, em vez de dissociar seus elementos constitutivos de forma abstrata.
PRÁTICAS DE PROFESSORAS ALFABETIZADORAS
Authors: Ferreira Lucimar Gracia , Barreto Denise Aparecida Brito , Ferreira Lúcia Gracia
Published: April 2022

Os estudos sobre as práticas pedagógicas/docentes de professores devem compor agendas atuais, pelo tema e sua relação com demandas contemporâneas, e dialogar com os saberes. Nessa perspectiva, realizamos uma investigação que objetivou compreender as aprendizagens da docência e aspectos formativos presentes nas práticas pedagógicas de três professoras alfabetizadoras de duas escolas públicas do município de Itapetinga-BA. Assim, realizamos uma pesquisa de abordagem qualitativa e caráter exploratório, utilizando a entrevista narrativa para produção dos dados. A análise de conteúdo foi a técnica de escolha para análise do corpus da pesquisa, que considerou duas categorias: 1) aprendizagens da docência na iniciação profissional; 2) processos formativos e aprendizagem da docência. Os resultados apontaram que as aprendizagens da docência emergem na atuação profissional quando da inserção na carreira e também da formação inicial e continuada. Ainda que a formação não vem dando conta das necessidades e demandas do desafio de alfabetizar. Desse modo, a pesquisa mostrou que as lacunas impõem a necessidade de melhor apreensão do conhecimento formal pedagógico para melhor atuação na condição de alfabetizadoras.
O TRÁGICO E A VELHICE
Authors: Silva Teresinha Vânia Zimbrão da , Pessoa Taynara Ribeiro
Published: April 2022

O presente trabalho apresenta uma reflexão sobre a velhice-morte a partir de estudos que discutem o conceito do trágico. Recorrendo à filosofia do trágico, aponta para as diferenças entre o gênero tragédia e o conceito filosófico, além de defender que os limites do trágico ultrapassam o espaço da tragédia, propondo então o rastreamento da persistência do trágico na contemporaneidade. Realiza ainda uma análise da temática da velhice-morte no romance a máquina de fazer espanhóis, do autor português Valter Hugo Mãe, com o objetivo de rastrear, na narração do protagonista da história, a compreensão trágica da finitude da vida e as reverberações desse sentimento na velhice.
“A HISTÓRIA DO TIMBÓ”
Authors: Rocha Barreto Mêrivania , Leal Izabela  Guimarães Guerra
Published: April 2022

A “História do Timbó”, publicada no livro Panton Piá – a história do Timbó faz parte do corpus de narrativas que apresentam a temática da metamorfose e que circulam na região Circum-Roraima – território dos indígenas Pemon (habitantes da região fronteiriça entre Brasil, Venezuela e República Cooperativa da Guiana). A proposta desta pesquisa consiste em fazer um estudo da narrativa “A história do Timbó”, com o objetivo de compreender/analisar as metamorfoses nela existente. Para isso, lançamos a hipótese de que, na narrativa em questão, possam existir, pelo menos, dois tipos de metamorfoses, a saber: as reversíveis e as irreversíveis. Para este estudo, nos apropriaremos de algumas concepções defendidas pelo perspectivismo ameríndio, bem como de alguns estudos sobre a temática da metamorfose. A pesquisa será de cunho investigativo bibliográfico e interpretativo, baseando-se nos estudos de Viveiros de Castro (1996-2008-2011), Lúcia Sá (2012-2017), Fábio Carvalho (2017), Devair Fiorotti e Clemente Flores (2019), Emanuele Coccia (2020), etc.
O ESPAÇO DA CIDADE E AS RELAÇÕES HOMOLÓGICAS ENTRE "RECÔNDITO" E "CHUVA, VAPOR E VELOCIDADE – O GRANDE CAMINHO DE FERRO DO OESTE"
Authors: Cavalcante Mairylande Nascimento , Tolomei Cristiane Navarrete
Published: April 2022

RESUMO: O presente artigo propõe realizar uma análise crítica do universo ficcional da obra Recôndito (2016), da autora maranhense Inês Pereira Maciel, em confluência com a obra de William Turner Chuva, Vapor e Velocidade- O Grande Caminho de Ferro do Oeste (1844). Nesse sentindo, tal estudo vislumbra compreender como a imagem da cidade é concebida, na percepção do eu poético e do pintor, como práticas conciliáveis de construções imagéticas na arte, seja ela poética e/ou visual. Este estudo se envereda pelos caminhos da Literatura Comparada, a qual nos possibilitará confrontar os elementos dispostos nas duas produções artísticas. Para tanto, foram delineados os seguintes objetivos: compreender como a fenomenologia da imagem é suscitada pela experiência do sujeito com o espaço, resultando a elaboração e reelaboração de múltiplos “eus”. Além disso, analisaremos as relações homológicas entre a poesia inesiana e a pintura de J. M. William Turner, sem subjugar a imagem tecida pelas palavras, nem tão pouco a que se derrama sobre a tela. Este trabalho é de cunho bibliográfico tendo como principais teóricos Tânia Carvalhal (2006), Sandra Nitrini (2010), Alfredo Bosi (1977), Foucault (2009), Lilian Hack (2020), Claus Clüver (2006), Gonçalves (1997), Halbwachs (2003), Joel Candau (2012), Le Goff (1996), Stuart Hall (2015), Tomaz Tadeu da Silva (2000), Santos (2013), Yi – Fu Tuan (1983;2012), Gaston Bachelard (2003) e Merleau-Ponty (1999). Ademais, salientamos que as imagens na escrita poética são o arcabouço da antecedencia imagética do pensamento, enquanto a pintura é a poesia derramada sobre a tela.
PATRIARCADO E VIOLÊNCIA EM ARLETE NOGUEIRA DA CRUZ
Authors: Brito Deyse , Tolomei Cristiane Navarrete
Published: April 2022

Este trabalho busca explicitar, a partir da teoria decolonial, dogmas e preceitos opressivos que circunscrevem a relação dominador x dominado, que advém de forma muito semelhante à relação colonizador x colonizado, explicitando que mesmo na ausência da política colonial, arrasta-se pelo mundo moderno, a existência da colonialidade. Pensando em como essas questões incidem no meio literário, busca-se fazer uma análise de da obra Compasso Binário (1972), de Arlete Nogueira da Cruz, a qual é costumeiramente marginalizada, tanto por ser escrito por mulher, quanto pelas questões que envolvem tabus, retratando o patriarcado opressivo e violências contra o corpo feminino, incidindo assim na colonialidade de gênero. Desse modo, este trabalho explicita a análise das personagens Baianinha e Natália, sendo uma prostituta e a outra estudante e estagiária de medicina, e consequentemente fazem parte de diferentes alas da sociedade ludovicense, no entanto as personagens têm suas vidas cruzadas na narrativa a partir da dominação masculina e da violência. Assim, parte-se do objetivo geral de realizar uma leitura analítica sob a abordagem da decolonialidade do romance maranhense Compasso Binário (1972) da escritora Arlete Nogueira da Cruz; quanto aos objetivos específicos tem-se o intuito de verificar como o romance Compasso Binário se relaciona com os aspectos que reverberam a colonialidade de gênero; e, analisar como as situações de dominação pater-colonial que são problematizadas na narrativa. Para tanta são utilizados os estudos de Lugones (2008), Maldonado-Torres (2016), e Mignolo (2017).
AS INFÂNCIAS NO “REINO GRANDE DO SUL": SCRIPTS DE GÊNERO NA LITERATURA PARA CRIANÇAS
Authors: Rosa Cristiano , Felipe Jane , Costa Vanessa
Published: April 2022

Neste trabalho realizamos uma análise narrativa dos livros da coleção “Reino Grande do Sul”, uma releitura dos clássicos infantis para o contexto da cultura gaúcha. Apoiados nos Estudos de Gênero e nos Estudos Culturais em uma perspectiva pós-estruturalista, problematizamos a constituição e representação de feminilidades e masculinidades das e dos protagonistas. Por meio das análises, que focaram tanto nos elementos quanto na estrutura das histórias, percebemos como os scripts de gênero estão inseridos nas narrativas, reforçando aspectos que, apesar de presentes nas tramas ficcionais, relacionam-se diretamente com a nossa realidade. Tanto os contos clássicos como os contos adaptados à cultura gaúcha são, em sua maioria, pautados por uma noção de superioridade masculina, enaltecendo o perfil de uma masculinidade aventureira, desbravadora do mundo e salvacionista, enquanto a mulher continua sendo visibilizada como submissa ao casamento, responsável pelo lar e cuidadora da família.
SUPERMERCADOS ENQUANTO ESPAÇOS DE CULTURA CIENTÍFICA: POSSIBILIDADES PARA O ENSINO DE QUÍMICA
Authors: Plácido Manoel Henrique Estércio Farias , Romero Rafaelle Bonzanini , Romero Adriano Lopes
Published: April 2022

Estudos recentes na área de Ensino de Ciências indicam ser necessário considerar a cultura científica como parte fundamental da formação dos cidadãos e que uma verdadeira cultura científica não pode ser separada da cultura clássica, mas deve ser considerada como parte integrante e essencial dela. Nesse contexto, o presente ensaio tem como objetivo indicar a potencialidade de supermercados como espaços que contribuem para a formação da cultura científica. Para isto, exploramos alguns termos (colesterol, glúten e fator de proteção solar), comumente observados em embalagens de produtos industrializados, que podem ser utilizados como temas de estudo em disciplinas de Química. Chamamos a atenção para o fato de alguns termos científicos serem utilizados apenas como marketing científico para influenciar a compra do produto, tal como os termos "sem colesterol" e "sem glúten". Defendemos que os supermercados são espaços coadjuvantes de divulgação da ciência e que, no contexto da Educação Básica, podem (e devem) ser entendidos pelos professores de Ciências como um rico espaço para trabalhar a cultura científica, uma vez que a produção dos inúmeros produtos ali contidos possuem muita ciência e tecnologia associadas. Trata-se, portanto, de uma possibilidade que permite ampliar a cultura clássica dos estudantes com a cultura científica, objetivo das disciplinas científicas.
O QUE É SER CIENTISTA PARA ESTUDANTES DE PEDAGOGIA?
Authors: Negrão Felipe da Costa , Andrade Alexandra Nascimento de , Morhy Priscila Eduarda Dessimoni
Published: April 2022

Esse artigo tem o objetivo de discutir as representações imagéticas do ser cientista de estudantes do curso de Pedagogia através da aplicação da atividade “a minha percepção do ser cientista” com nove discentes matriculados na disciplina “Conteúdo e Metodologia do Ensino de Ciências”. No viés metodológico, essa pesquisa qualitativa utilizou-se das representações sociais por meio do desenho e das narrativas escritas dos sujeitos participantes. O movimento de análise, ancorou-se em Bardin (2016), evidenciando três categorias a partir dos dados coletados, a saber: a) cientista herói; b) cientista de laboratório; e c) a mulher na ciência. Os resultados denunciam a visão estereotipada do cientista, associando-o, majoritariamente, ao ambiente laboratorial e com atributos hercúleos, de modo que, por meio das análises, acreditamos que tal compreensão pode estar vinculada a ênfase midiática dada a essa face do cientista. Além disso, o trabalho identificou a pouca representação da mulher cientista nos desenhos dos graduandos, desvelando questões históricas e sociais que marcam a trajetória e a disparidade de gênero na ciência. Sendo assim, o estudo traz elementos importantes para novas investigações e discussões no âmbito da formação de professores, especialmente, sobre as práticas, áreas de atuação e multifaces do ser cientista.
POLÍTICAS EDUCACIONAIS PARA A INCLUSÃO DE ESTUDANTES COM DEFICIÊNCIA
Authors: Navarrete-Cazales Zaira , Manzanilla-Granados Héctor Manuel , Ocaña-Pérez Lorena
Published: April 2022

O objetivo deste artigo é apresentar uma análise das políticas educacionais e currículos atuais para inclusão no nível do ensino primário, bem como uma revisão dos dados sobre a população com deficiências no México, enquanto a educação à distância é proposta como meio de inclusão para estudantes com deficiências. Esta pesquisa teórico-analítica e documental retoma a perspectiva dos direitos humanos para sua análise, considerando que a educação é um direito fundamental para todas as pessoas no mundo, razão pela qual se considera que o Estado tem o poder de estabelecer um modelo de educação capaz de cobrir as necessidades de treinamento, mesmo daqueles que não podem viajar fisicamente para instituições educacionais. Conclui-se que apesar das modificações feitas nas Políticas de Educação desde meados do século XX, a inclusão universal - para todos os estudantes - ainda não é alcançável no México, muito menos para os estudantes desfavorecidos ou vulneráveis.
Taking Advantage of 3D Human Cell Culture Platforms to Study Pulmonary Fibrotic Diseases
Authors: Piedade Francisca , Santos Sara , Ferreira Beatriz , Mano João , Custódio Catarina , Almeida Catarina
Published: April 2022

Pulmonary fibrosis consists of progressive and irreversible lung tissue
stiffening that is typically associated with organ failure. This is a
major health problem and a leading cause of death worldwide. The
mainstays of current therapy for lung fibrosis rely on lung
transplantation in end-stage fibrotic diseases, which has severe
limitations, such as the shortage of organ donors and risk of rejection.
There is thus an active search for efficient treatments, which can only
be achieved with a better understanding of pulmonary fibrosis
pathophysiology. Recent advances in 3D tissue engineering led to the
development of platforms for drug testing, and that contribute to a
better understanding of pulmonary fibrosis pathophysiology. These
complex 3D lung platforms recapitulate lung function, structure, and
cell and matrix interactions, therefore providing the means for
understanding the mechanisms and mediators involved in the fibrotic
process. In this perspective, this review discusses the most relevant 3D
cell culture platforms to engineer fibrotic lung models as well as their
in vitro applications.
General decay for a von Karman plate system with general type of relaxation functions on the boundary
Authors: Kang Jum-Ran
Published: April 2022

In this paper, we consider a von Karman plate system with general type
of relaxation functions on the boundary. Using some properties of the
convex functions without the assumption that initial value w_0
\equiv 0 on the boundary, we study the general decay rate
result.
Genome Screening, Reporting and Counseling for Healthy Populations
Authors: Casalino Selina , Frangione Erika , Chung Monica , MacDonald Georgia , Chowdhary Sunakshi , Mighton Chloe , Faghfoury Hanna , Bombard Yvonne , Strug Lisa , Pugh Trevor , Simpson Jared , Greenfeld Elena , Hao Limin , Lebo Matthew , Lane William , Noor Abdul , Taher Jennifer , Lerner-Ellis Jordan , GENCOV Study Workgroup
Published: April 2022

Introduction: Rapid advancements of genome sequencing (GS)
technologies have enhanced our understanding of the relationship between
genes and human disease. In order to incorporate genomic information
into the practice of medicine, new processes for the analysis, reporting
and communication of GS data are needed. Methods: blood samples
were collected from adults with a PCR-confirmed SARS-CoV-2 (COVID-19)
diagnosis (target N=1500). GS was performed. Data was filtered and
analyzed using custom pipelines and gene panels. We developed unique
patient-facing materials, including an online intake survey, group
counseling presentation, and consultation letters in addition to a
comprehensive GS report. Results: The final report includes
results generated from GS data: 1) Monogenic disease risks; 2) Carrier
status; 3) Pharmacogenomic variants; 4) Polygenic risk scores for common
conditions; 5) HLA genotype; 6) Genetic ancestry; 7) Blood group; and,
8) COVID-19 viral lineage. Participants complete pre-test genetic
counseling and confirm preferences for secondary findings before
receiving results. Counseling and referrals are initiated for clinically
significant findings. Conclusion: We developed a genetic
counseling, reporting, and return of results framework that integrates
GS information across multiple areas of human health, presenting
possibilities for the clinical application of comprehensive GS data in
healthy individuals.
Pallister-Hall syndrome diagnosed in a young man after an acute adrenal crisis
Authors: Grassa Anis , Yazidi Meriem , Marrakchi Jihene , Sliman Chaima Bel Hadj , Oueslati Ibtissem , Chihaoui Melika
Published: April 2022

Pallister-Hall syndrome is a very rare genetic disorder. The diagnosis
is usually suspected at the young age when a hypothalamic hamartoma is
associated with polydactyly. We report the case of an 18-year-old man in
whom the diagnosis of PHS was made during his hospitalization for acute
adrenal insufficiency.
Putative biotic drivers of plant phenology: with special reference to pathogens and deciduousness
Authors: Burdon Rowland
Published: April 2022

Plant phenology is manifested in the seasonal timing of vegetative and
reproductive processes, but also has ontogenetic aspects. The adaptive
basis of seasonal phenology has been considered mainly in terms of
climatic drivers. However, some biotic factors as likely evolutionary
influences on plants’ phenology appear to have been under-researched.
Several specific cases of putative biotic factors driving plant
phenology are outlined, involving both herbivores and pathogens. These
illustrate the diversity of likely interactions rather than any
systematic coverage or review. Emphasis is on woody perennials, in which
phenology is often most multi-faceted and complicated by the ontogenetic
aspect. The complete seasonal leaf fall that characterises deciduous
plants may be a very important defence against some pathogens. Whether
biotic influences drive acquisition or long-term persistence of
deciduousness is considered. In one case; of leaf rusts in poplars,
countervailing influences of the rusts and climate suggest persistence.
Often, however, biotic and environmental influences likely reinforce
each other. The timing and duration of shoot flushing may in at least
some cases contribute to defences against herbivores, largely through
brief periods of ‘predator satiation’ when plant tissues have highest
food value. Wide re-examination of plant phenology, accommodating the
roles of biotic factors and their interplays with environments as
additional adaptive drivers, is advocated, towards developing and
applying hypotheses that are observationally or experimentally testable.
Development of Self-folded Corrugated Structures Using Automatic Origami Technique by Inkjet Printing
Authors: Fukatsu Yuki , Shigemune Hiroki
Published: April 2022

The origami technique realizes unique mechanical properties of sheet
materials without additional parts. In this study, a self-folded
corrugated structure (SCS) is developed based on the reinforcing
properties of the origami technique. The corrugated structures are
employed as the core material for a high-strength, open-channel sandwich
structure. Research on self-folded core materials is scarce; thus, a
design concept is proposed, and the mechanical properties of the SCS are
evaluated. First, the structural parameters of the SCS fabricated by
changing the printing parameters (e.g., linewidth and number of
lines/creases), to derive the structural model are determined. The model
facilitates the design of an SCS with the desired structure. Thereafter,
the mechanical properties of the SCSs are evaluated by conducting
three-point bending tests to determine the essential design parameters
corresponding to high stiffness. Moreover, SCSs can be stacked without
occupying space, thus leading to improved strength. These SCSs
fabricated using self-folding paper by ink-jet printing are low cost and
eco-friendly. Moreover, they are specialized for rapid design and
fabrication, depending on the application. This paper proposes the use
of SCS as a novel smart core because it exhibits a high transportation
efficiency and stiffness without additional components.

Corresponding author(s) Email: ae18081@shibaura-it.ac.jp ,
hshige@shibaura-it.ac.jp
Availability evaluation of healthcare IoT infrastructures
Authors: Moraes Thays , Borba Eric , Franca Cleunio , Tavares Eduardo
Published: April 2022

Healthcare applications may have strict availability requirements, such
that system failures can affect patient monitoring. Therefore, a failure
may lead to serious problems regarding patient health. This paper
presents an approach for assessing the availability of healthcare
Internet of Things (IoT) systems using Reliability Block Diagrams (RBD).
A case study is presented for a hospital environment, in which patients
are under constant observation. A sensitivity analysis is also carried
out to identify the most influential components, and, then, we propose
mechanisms to mitigate the impact of component failure.
Mechanism of αO-Conotoxin GeXIVA[1,2], a Novel Nonaddictive Analgesic, Based on In Vivo Disposition and Modelling
Authors: Zhu Xiaoyu , yuan mei , Wang Huanbai , zhangsun dongting , Yu Gang , Che Jijing , Su Lan
Published: April 2022

Background and purpose: αO-conotoxin GeXIVA[1,2], a natural peptide
discovered by our laboratory from Conus generalis in the South China
Sea, is a novel nonaddictive analgesic targeting the α9α10 nicotinic
acetylcholine receptor (nAChR). This study aimed to elucidate the
underlying mechanisms by the disposition and modelling of
GeXIVA[1,2]. Experimental approach: The pharmacokinetics (PK) of
GeXIVA[1,2] and tissue distribution in rats and dogs were studied. A
population pharmacokinetics model and a pharmacokinetic-pharmacodynamic
model were developed based on animal data and used to predict the
efficacious dose in humans and explain the mechanism. Key results: The
intramuscular bioavailability of GeXIVA[1,2] was 11.47% and 13.37%
in rats and dogs, respectively. Across experimental doses, the plasma
exposure increased approximately in proportion to dose, and the
half-life of GeXIVA[1,2] ranged from 5.37±0.99 to 19.65±6.21 min.
GeXIVA[1,2] had less extensive tissue distribution. The bound
fractions differed in human, rat, and dog plasma, ranging from
55.85±5.10% to 87.64±7.49%. The one-compartment model with the
first-order absorption PPK model estimated an efficacious dose of
11.9-30.8 μg·kg-1 in a 70 kg human with bodyweight as a covariant. The
inhibitory loss indirect response model combined with an effect
compartment adequately described PK-PD relationships. Conclusion and
implications: We speculated that GeXIVA[1,2] exerts analgesia by
inhibiting the elimination of certain endogenous substances, which may
be a key pharmacodynamic biomarker. This is the first report of the
disposition of conotoxin-derived therapeutic agents and possible
analgesic mechanisms of α9α10 nAChR, which were elucidated by PK studies
and modelling approaches.
A Semi-Empirical correlation for stratified two-phase flow friction factors
Authors: Ranjbari Pouya , Emamzadeh Mohammad
Published: April 2022

The optimal design of two-phase flow pipes depends on various variables.
Pressure drop and liquid hold-up are essential parameters in the
appropriate design of pipes. These parameters can be estimated by
numerical simulation of pipes. However, the simulation strongly depends
on both phase frictions. Frictions are commonly calculated using
friction factors, and various empirical correlations have been proposed
to calculate friction factors, but most of these correlations are
dependent on the experimental conditions. The present study proposes a
semi-empirical friction factor model by modifying an existing model in
the literature for stratified two-phase flows. Experimental data from
various laboratories are taken to validate the interface shear stress,
velocity profile and pressure gradient. Compared with previous models,
the predicted velocity profiles and shear stresses are in better
agreement with the experimental data.
High risk population screening for Fabry disease in hemodialysis patients in Vojvodina: Pilot study
Authors: Celic Dejan , Pavlovic Sonja , Skakic Anita , Vucenovic Jelica , Pilipovic Dragana , Golubovic Sonja , Stojsic Tatjana , Milicevic Olivera , Vojinovic Goran , Dudic Svetlana , Petrovic Lada , Mitic Igor
Published: April 2022

Introduction/Objective. Fabry disease (FD) is an X-linked lysosomal storage disease that develops as a consequence of mutation in the alpha-galactosidase A (GLA) gene. There are more than 1080 known variants in the GLA gene. Some of them are pathogenic, but most of them are benign or represent the genetic change that can be classified as a genetic variant of unknown significance or simply be a representation of genetic polymorphism. There are two main features of FD, classic form and late-onset variants of disease. The main target organs in patients with FD are the kidneys, heart, and nervous system. Bearing in mind the fact that FD is a rare disease, the best way for active searching of patients is high-risk population screening, after which family screening for every proband case should be performed. Methods. In this paper, we present results of a multicentric pilot study that represents findings from the screening of hemodialysis patients for FD in six hemodialysis units in Vojvodina. Results. We have found one patient with benign mutation and 16 patients with genetic polymorphisms in GLA gene. We have learned that genetic changes in GLA gene can be frequent, but very rarely are of clinical significance and lead to manifestations of FD. Conclusion. Results of this screening study will give us important insights into our future work.
Simulating flow and heat transfer in a variety of diesel particulate filter porous structures using lattice Boltzmann method
Authors: Yang Qirong , Zhang Tiechen , Li Menghan , Liu Xiaori
Published: April 2022

Particulate matter has important influences on premature human mortality. Diesel particulate filter is one of the most effective means to reduce particulate matter in exhaust gas. In order to study the 3-D flow characteristics of diesel particulate filter porous structure, lattice Boltzmann method is used to study the flow and heat transfer characteristics of different structures. In some software, the spherical structure is used as diesel particulate filter porous structure. In paper, the spherical structure, the quartet structure generation set structure, and the computer tomography technique structure are constructed. The computer tomography technique structure is constructed by the serial sections of diesel particulate filter porous structure. The flow and heat transfer characteristics in different structures were simulated by lattice Boltzmann method. The 3-D computer tomography technique structure is constructed by superposing the serial section data of diesel particulate filter. The results show that the pressure gradient and temperature gradient of structures are greatly affected by the structure. The pressure gradient and temperature gradient of the spherical structure is the lowest. The spherical structure and the quartet structure generation set structure are different from the porous structure of diesel particulate filter in pressure gradient and temperature gradient. By comparing different structures, it can be seen that although the pressure gradients of the computer tomography technique structure and the quartet structure generation set structure are similar, the temperature gradient of the two structures are more different.
Isolated fracture of the lesser tuberosity of the humerus – a rare injury that requires surgical treatment
Authors: Glisic Miodrag , Stevanovic Vladan , Jevtic Aleksandar , Jovicevic Uros , Jankovic Ivan
Published: April 2022

Introduction. An isolated fracture of the small tuberosity is a very rare injury that can often be overlooked. That injury is significant due to the function of the subscapularis muscle, which loses its attachment by separating the small tuberosity. Case report. A 45-year-old male, former athlete, suffered a left shoulder injury while falling downhill. Although the clinical picture was not convincing, a computed tomography scan showed a fracture. Open repositioning and osteosynthesis were performed. After rehabilitation, the patient regained a full active range of motion in the shoulder joint three months after the operation. We present the mechanism of injury, clinical picture, necessary diagnostics, and technique of surgical treatment of isolated fracture lesser tuberosity of the humerus. The results of other authors whose series are also quite small were analyzed. Conclusion. It was concluded that an isolated fracture of the small tuberosity requires surgical treatment to preserve a good range of motion in the shoulder joint.
Sensorimotor rhythm neurofeedback training and auditory perception
Authors: Stankovic Ivana , Ilic Nela , Ilic Tihomir , Jelicic Ljiljana , Sovilj Mirjana , Martic Vesna , Punisic Silvana , Stokic Miodrag
Published: April 2022

Background/Aim. In everyday communication, people are exposed to a myriad of sounds that need to be sorted and relevant information extracted. The ability of a person to concentrate on certain sounds in a noisy background environment, perform selective attention, and focus their auditory attention is crucial for everyday functioning and communication. The aim of this study was to investigate the effect of the sensorimotor rhythm (SMR) (12?15 Hz) neurofeedback (NFB) training to improve auditory cognition measured by the achievements in the Quick speech-in-noise (QuickSIN) test, changes in the amplitudes and latencies of components of auditory evoked potentials (AEP) N100, N200, and P300 in the auditory oddball discrimination task, and changes in the spectral power of the SMR. Methods. The study included 16 healthy participants aged 25?40 years (8 males and 8 females). Each participant had 20 daily sessions of SMR NFB training. Auditory cognitive functions and electrophysiological correlates of cognitive processing were recorded 5 times ? before NFB, after 5, 10, and 20 sessions, and one month after the last session of NFB. Re-sults. The results showed a statistically significant decrease in N200 and P300 latencies at frontal midline (Fz), central midline (Cz), and parietal midline (Pz) regions, an improvement on the QuickSIN test, and an increase in electroencephalogram SMR rhythm spectral power in the Cz region as a result of the NFB SMR training. No significant effect of the NFB training on the N100, N200, and P300 amplitudes on Fz, Cz, and Pz was found. Conclusion. The obtained results suggest that SMR NFB affects auditory perception in terms of shorter latencies of AEP and better performance on the QuickSIN test.
Novel Central Line Securement Vest to Prevent Mechanical Complications of Tunneled Central Lines: Experience from a Cohort of Pediatric Patients with Intestinal Failure
Authors: St. Pierre-Hetz Ryan , Ackerman Kimberly , Dresser Christian P. , Yaworski Jane Anne , Cercone Angelica , Rudolph Jeffrey , Wisniewski Stephen R. , Manole Mioara D.
Published: April 2022

Highlights

Background:

Tunneled central lines are used to deliver medications, hydration, and total parenteral nutrition. The current modality for their securement is by a transparent sterile adhesive. Mechanical line traumas, including line fissures, breaks and dislodgements, occur frequently in children. A novel device, the Central Line Securement Vest, was created to protect central lines from mechanical trauma.

Objective:

We present here our experience with the device and report its use in patients with intestinal failure treated at our institution.

Methods:

All patients who have used the Central Line Securement Vest at our institution during the last decade were identified. We reviewed the patients’ electronic records and compared the rate of line mechanical trauma, line infections, line replacements, Emergency Department (ED) visits, and hospital admissions for a period of 12 months before and after the use of the device.

Results:

Ten patients were identified. Four patients had purchased the device at the time of line insertion. Six patients had a period of time of line use before beginning use of the device. The rate of line traumas and infections decreased after using the device: 0.19 ± 0.15 vs 0.05 ± 0.04 trauma/month, pre– vs post–device use, P < 0.05. Similarly, the rate of line infections decreased post–device use: 0.18 ± 0.13 vs 0.09 ± 0.06 infections/month, pre– vs post–device use, P < 0.05. The rate of line replacements, ED visits, and hospital admissions were similar pre– and post–device use.

Conclusion:

We report here our institution’s experience with a novel central line securement device designed to protect the line from mechanical trauma.
Effect of Added Pectin and Microcrystalline Cellulose (MCC) on Capsule Shell Quality
Authors: Agustin Nuke , Lismeri Lia , Azwar Edwin
Published: April 2022

The objective of this study was analyzing the effect of the added pectin and microcrystalline cellulose (mcc) on the capsule shell quality. The method used in this study was by combining the pectin and microcrystalline cellulose composition on capsule shell manufacture. The formulation used to test the capsule shells was through 1 gram, 2 gram, 3 gram of pectin; 0 gram and 1.5 gram of microcrystalline cellulose; 1 gram of glycerol; and, 1 gram of carrageenan. The experiment tests used in this study were through the organoleptic test, the capsule weight test, the moisture test, the pH test, the dissolution time test, and the capsule-length test. The result of this study showed that the recommended formulation used to manufacture the hard capsule shells was through 3 gram pectin and 1.5 gram microcrystalline cellulose. The required temperature to heat the pectin and microcrystalline cellulose was at 90oC with 2.5-hour heating time. The characteristics of the manufactured capsule shells were that it had a turbid colour and irregular shape, the surface was not smooth and the disintegration time was 9 minutes and 21 seconds.

 

Keywords: Capsule Shell, Microcrystalline Cellulose, Pectin, Variation, Testing
ANALISIS KINERJA PRODUKSI, HARGA POKOK PENJUALAN DAN STRATEGI OPERASIONAL AGROINDUSTRI (STUDI KASUS AGROINDUSTRI KERIPIK PISANG PANDA ALAMI DI KABUPATEN PESAWARAN)
Authors: Balqis Nabilah Rohma , Haryono Dwi , Nugraha Adia
Published: April 2022

The research aims to analyze the production performance, determine production cost, determine selling cost and determine the priority of banana chips agroindustry operational strategy.  Respondents were the owner, employees and field workers at Dinas Perindustrian & Perdagangan in Pesawaran Regency.  Data were analyzed using a quantitative and qualitative analysis (analysis of production performance), descriptive quantitative (production cost and selling cost) and also descriptive qualitative analysis (SWOT).  The results of this research showed that production performances of banana chips agroindustry in terms of capacity, quality, delivery speed and processing speed have been good, but in terms of productivity and flexibility are still not optimal.  Price of banana chips is IDR78,782.50/kg with the determine production cost of IDR42,062.50/kg and determine selling cost IDR42,226.80/kg with profit margin of 86.57 percent.  The main strategy of priorities are (1) increasing productivity by utilizing raw materials and technology, (2) improving product quality by utilizing technology, (3) establishing partnerships with other outlets to introduce products by improving product quality, (4) utilizing technology to increase agroindustry profits, (5) owner of agroindustry determine production policies in accordance with high community needs and utilize the skills of agroindustrial human resources. (6) government support to increase production. Key words: operational strategies, production performance, selling cost
ANALISIS PENGADAAN BAHAN BAKU, KEUNTUNGAN, SALURAN PEMASARAN, DAN JASA LAYANGAN PENDUKUNG AGROINDUSTRI KERIPIK SINGKONG DIKELURAHAN GANJAR ASRIKECAMATANMETRO BARATKOTA METRO
Authors: Sulistioningrum Yuli Dwi , Murniati Ktut , Nugraha Adia
Published: April 2022

This research aims to: analyze the procurement of raw materials, profits, marketing channels,and the role of cassava chip agroindustry support services in Ganjar Asri Village. This study used a census method on five agroindustry cassava chips in Ganjar Asri Village West Metro Subdistrict Metro District. The determination of the location was done deliberately with the consideration that Ganjar Asri Village was a center of cassava chipsagroindustry actively produce and have the potential to be developed. The respondents were the owners of five agroindustries. The results showed that: there are two components of raw material procurement that were in accordance with expectations carried out by the five cassava chips agroindustries, namely quantity and type, while the other five components have not been in accordance with expectations, namely time, place, quality, and price. The highest profit is in Matahari Agroindustry and amounted to IDR 1,412,017.80 in one production. All agroindustries have benefits, so they were worthy of effort and development. Support services that helped the process of cassava chip agroindustry activities are financial institutions, transportation facilities, and communication information technology.Key words: advantage, agroindustry, cassava chips.