bluuebunny/crossref_metadata_2025 huggingface dataset:
SISTEM INFORMASI PENGGAJIAN PEGAWAI PADA DINAS TENAGA KERJA KOTA BANDUNG
Authors: Rivatunisa Cyntia
Published: December 2022

Kebutuhan akan informasi saat ini semakin meningkat seiring dengan perkembangan teknologi, begitu pula kebutuhan informasi penggajian pegawai pada Dinas Tenaga Kerja Kota Bandung.  Pelaksanaannya informasi penggajian pegawai ini masih mengalami kendala seperti penyajian data pegawai dan data gaji memakan waktu yang cukup lama dan terkadang terjadi keterlambatan dalam pencarian data dan lambatnya pengolahan gaji dan juga mengakibatkan pembuatan laporan yang lambat. Peneltian ini bertujuan untuk membangun Sistem Informasi Penggajian Pegawai di Dinas Tenaga Kerja Kota Bandung sehingga dapat membantu pihak terkait didalam mendapatkan informasi yang tepat, cepat dan akurat. Metode pengumpulan data penulis menggunakan metode wawancara, observasi, dan studi dokumentasi. Dalam pengembangan sistem, penulis menggunakan metode pendekatan Prototyping . Untuk perancangan basis data digunakan metode normalisasi, relasi tabel, dan diagram relasi entitas. Implementasi dan rancangan program menggunakan bahasa pemograman Visual Basic 6.0 dan database MySQL. Berdasarkan hasil penelitian dapat diketahui bahwa sistem informasi penggajian pegawai pada Dinas Tenaga Kerja Kota Bandung masih mengalami kendala, dikarenakan Banyak kelemahan dalam pengolahan data yang sedang berjalan, seperti penyajian data pegawai dan data gaji memakan waktu yang cukup lama dan terkadang terjadi keterlambatan dalam pencarian data dan lambatnya pengolahan gaji dan juga mengakibatkan pembuatan laporan yang lambat.
PERANCANGAN SISTEM INFORMASI HUMAN RESOURCE DEVELOPMENT BERBASIS WEB MENGGUNAKAN FRAMEWORK ODOO DI PT. NURO INTELIA PROSPERA JAKARTA
Authors: Agustin Cahyadi , Rizaldi Yusup Firman
Published: December 2022

Penelitian ini bertujuan untuk menganalisis, merancang dan membangun implementasi sistem informasi Human Resource Development di PT. NURO INTELIA PROSPERA JAKARTA. Metode penelitian yang digunakan adalah metode deskriptif kualitatif. Teknik pengumpulan data yang digunakan adalah studi pustaka, studi lapangan. Metode yang digunakan dalam pengembangan sistem adalah waterfall. Dari penelitian yang dilakukan, ditemukan bahwa ada masalah dalam pengelolaan Human Resource Development. Proses pengelolaan data integrasi masih belum secara global sehingga masih belum efektif baik dalam prosedur penginputan data, penyimpanan data, pencarian data maupun dalam pembuatan laporan. Oleh karena itu dibuat sistem informasi Human Resource Development dengan menggunakan bahasa pemrograman Python serta PostgreSQL sebagai Database.

Adapun saran yang diberikan untuk menangani permasalahan yang ada antara lain yaitu : 1) Mengoptimalkan sistem Human Resource Development dengan menggunakan sistem yang telah dirancang, 2) Melakukan pengembangan dan pembaharuan pada sistem untuk meningkatkan kualitas sistem sehingga dapat digunakan secara lanjut.
The Principles Of Marketing 3.0 Of Electronic Commerce On The Next Web
Authors: Gatomatis Panayiotis , Nikolaos Bogonikolos Dr. , Chatzichristos Ioannis
Published: December 2022

In web-based marketing, the constant growth of the Internet has thrown up inconceivable opportunities and problems. Web 3.0, the most recent version of the web, is believed to be a technologically sophisticated medium that allows users to Read/Write/Execute and also allows robots to perform some of the thinking formerly reserved for human beings, but also as a game changer on the existing business models on which digital marketing is conducting nowadays. The emerging economics burgeoning Internet population will soon have an array of Web 3.0 in which to work and play. Although some strategies of web 3.0 platforms have been proven to be successful for attracting user acceptance in the developed countries, the effects of these strategies are questionable in the market of emerging economics. In this study, we investigate the Web 3.0 market and e-commerce strategies. Based on the uses and gratifications theory, this study compares the different strategies of these local companies, and tries to explain which difference of e-commerce strategies between these competitors, and how can these Web 3.0 competitors survive in the environment of emerging economics. Limitations and Implications are discussed in the end.
Henry Worrall (1825–1902): Anglo-American Guitarist
Authors: Ferguson Robert
Published: December 2022

Anglo-American guitarist Henry Worrall appeared on the American scene just as the guitar reached a plateau of popularity. As vital as the guitar itself, the prevailing social, philosophical, and aesthetic tenets of Worrall's era also wove a unifying thread through his life, career, and oeuvre. His immersion in both the graphic and musical arts; his straddling of vernacular and high culture; his connection to nature and especially agriculture; his nationalist and regionalist sympathies; and his fondness for folk, popular, and heroic musical themes all drew from and evinced a Romantic worldview. Here, Ferguson discusses Worrall's professional life.
Soundboard Scholar no. 3: Editor's Letter
Authors: Heck Thomas
Published: December 2022

An introduction to the contents of this issue.
Andrés Segovia’s Unfinished Guitar Method: Placing His “Scales” in Historical Context
Authors: Stevens Andreas
Published: December 2022

For over sixty years, guitarists of my generation have been familiar with the so-called Segovia Scales--the systematic scale fingerings advocated by the Andalusian maestro. They have been an influential--some might say a definitive--bestseller since their first USA publication in 1953. Countless guitar students have incorporated them into their daily practice routines. For the publisher, Columbia Music Co., they seem to be the goose that laid the golden egg. Are they everything that Segovia wanted them to be? Two books of recent date on guitar technique attest to their enduring value and relevance. Thomas Offermann wrote in 2015: "The fingerings of the scales used here mostly correspond to those of Andrés Segovia." revised edition of the 1953 publication came out in 1967. It was republished in 2011 and has remained in print. The original preface by Segovia was partly removed and replaced by a "Historical Note" by Thea E. Smith, the granddaughter of the publisher, Sophocles Papas. She attested that they were "one of the best-selling guitar publications of all time.
Napoléon Coste: Composer and Guitarist in the Musical Life of 19th-Century Paris by Ari Van Vliet
Authors: Long Richard
Published: December 2022

Napoleon Coste: Composer and Guitarist in the Musical Life of 19th-Century Paris, by Van Vliet, Ari is reviewed.
Association Between Breastfeeding And Clinical Outcomes Of Infants With Very Severe Pneumonia
Authors: Laguna-Cruz Cherrylyn , Becina Gener
Published: December 2022

Objective: To determine the association of breastfeeding with the clinical outcomes of infants with very severe pneumonia. Methods: This retrospective study included intubated, full-term infants between one to six months of age admitted for very severe pneumonia at the critical care units of the National Children’s Hospital from 2005 to-2015. The 52 subjects per type of feeding (exclusively breastfed and non-exclusively breastfed) were selected using simple random sampling. We examined the association between the type of feeding with the length of ICU stay, ventilator days, health-care-associated infection (HAI) and mortality. Results: A total of 104 infants were included in the study. The exclusively breastfed (EBF) infants stayed for a shorter amount of time in the ICU than the non-exclusively breastfed (NEBF) infants (p-value = 0.0067). The EBF infants had shorter intubation period and mechanical ventilation use (p value=0.001), and less HAI (p-value = 0.015). There were more infants with very severe pneumonia who died from the NEBF group but no significant association (p-value = 0.076) was found between mortality and the type of feeding. Conclusion: Exclusively breastfed infants who were admitted for very severe pneumonia at the critical care areas showed better outcomes in terms of shorter ICU stay and ventilator use, and lower incidence of HAI as compared to the NEBF infants. However, data showed no significant association between mortality and type of feeding.
Effect Of Bovine Colostrum On The Absolute Neutrophil Counts Of Acute Lymphocytic Leukemia Patients Undergoing Chemotherapy: A Double-Blind Randomized Placebo-Controlled Study
Authors: Caysido Edith Cyrill , Ganggangan Ferdinand , Runez Rainelda
Published: December 2022

Background: Changes in the blood cell counts, such as leukopenia and neutropenia, in patients with Acute Lymphoblastic Leukemia (ALL) are common events following chemotherapy. These commonly delay further administration of chemotherapeutic agents. Furthermore, the risk of infection rises correspondingly with the degree of neutropenia. Bovine colostrum is a rich source of immunoglobulins and other antimicrobial factors. These immunoglobulins are believed to improve the immune function and may be effective in the prevention of neutropenia following chemotherapy. Objective: To determine the efficacy of bovine colostrum in preventing neutropenia among ALL patients undergoing chemotherapy. Methods: This study included pediatric patients, aged 6 months to 18 years old diagnosed with ALL undergoing chemotherapy. Twenty-one subjects were randomly assigned to receive bovine colostrum or placebo that were taken twice a day for a week beginning from the first day of chemotherapy. Baseline complete blood count (CBC) and the absolute neutrophil count (ANC) were determined before and after 7 days of giving the colostrum or placebo. A ttest was applied to determine significant differences before and after the supplementation on each group. Results: Results showed that there was a significant increase in ANC of patients given bovine colostrum as compared to the placebo group with a pvalue of 0.007. There were also significant increases in the white blood cells and platelet counts in those who were given bovine colostrum, with p-values of Conclusion: Exclusively breastfed infants who were admitted for very severe pneumonia at the critical care areas showed better outcomes in terms of shorter ICU stay and ventilator use, and lower incidence of HAI as compared to the NEBF infants. However, data showed no significant association between mortality and type of feeding.
Predictive Factors Of Treatment Failure For Pediatric Community-Acquired Pneumonia C And D In 2-To-59 Months Of Age
Authors: Zuniga Charisse , Garcia Robert Dennis , Villon Rozaida
Published: December 2022

Objective: To determine antibiotic treatment failure rate and predictors of treatment failure in children 2 to-59 months with Pediatric Community Acquired Pneumonia-C (PCAP-C) and PCAP-D admitted at Makati Medical Center. Methods: This prospective cohort study examined 100 children, 2-to-59 months with clinically diagnosed PCAP-C and PCAP-D. Baseline assessment was done on day 1 of hospital stay and follow-up assessments were done on days 3 and 7 or upon discharge for the outcomes of interest. Results: One hundred children were included in the study and 98% had PCAP-C. This study identified a treatment failure rate of 17% among children with PCAP-C. There was no mortality. Malnutrition and low oxygen saturation on admission were significant predictors of treatment failure. Conclusion: Antibiotic treatment failure rate was 17%. Malnutrition and hypoxia were significant predictors of treatment failure in children with PCAPC.
"Hansen’s Disease in an Adolescent: A Case Report "
Authors: Asuncion Patricia Carla , Lota-Salvado Rhanee
Published: December 2022

Abstract: Leprosy is a chronic communicable disease that remains to be endemic worldwide and children and adolescents are most vulnerable to infection. A 17-year-old Filipina presented with a 4-year history of multiple skin lesions evolving into various forms, associated with pain and deformity of extremities. She was diagnosed with Hansen’s disease, lepromatous type, in severe erythema nodosum leprosum. She was started on multi-drug therapy with Rifampicin, Clofazimine and Clarithromycin. There was remarkable improvement with arrested progression of skin lesions, conversion of wounds into granulation tissue, significant decrease in painful sensation, and gradual ability to move the extremities. Early recognition of leprosy and prompt initiation of treatment will ultimately prevent complications and disabilities in afflicted patients. A holistic approach is key in the management of children and adolescents with leprosy.
A Retrospective Study on the Outcome of Children with Extensively Drug-Resistant Gram-Negative Infection Treated with Colistin vs. Other Antimicrobials
Authors: Batalla - Bocaling Carren Anne , Paje - Villar Estrella
Published: December 2022

Introduction: The increasing trend of extensively drug-resistant gram-negative infections led to the reconsideration of colistin as a valuable therapeutic option. Objectives: To describe the clinical profile and treatment response of children with extensively drug resistant (XDR) Gram-negative infections given colistin versus other antimicrobials. Methods: This retrospective descriptive study involved patients treated for XDR Gram-negative infections from January 2014 to June 2017 in a tertiary hospital in Metro Manila. Descriptive statistics were used to summarize clinical characteristics of subjects. Treatment response to colistin versus other antimicrobial agents were compared in terms of success, failure, and toxicity. The Fisher-exact and Mann Whitney U tests were used to assess statistical differences between the colistin and non-colistin groups. Results: Majority of patients with XDR Gramnegative infections had previous antibiotic exposure. More patients in the colistin group received TPN 43.2% vs 23.7% (p=0.035), had a longer hospital stay prior to the onset of XDR Gram-negative infection, 27 days vs. 15.5 days (p=0.001), and had a longer total hospital stay with a median of 52 days vs 30 days (p < 0.001). Treatment success was significantly higher in the colistin group at 70.3%, as against 46.5% in the non-colistin group (p=0.014). There was no difference in the treatment duration of both groups. The colistin group had longer time to clinical response, with a mean of 6.27 (+ 3.57) days compared with those from the non-colistin group, with a mean of 4.36 (+ 1.77)(p=0.008). The colistin group had more fungal infections during the course of treatment (p=0.001). Conclusion: Based on our institutional experience, colistin is considered relatively effective and safe in treating XDR Gram-negative infections in children.
Epidemiology and Outcome of Children Living with HIV in a Tertiary Hospital: A 6-Year Retrospective Study
Authors: Delos Santos-Jamora Mary Crist , Pagcatipunan Marimel
Published: December 2022

ntroduction: Infection with HIV is multi-faceted and involves the interplay of medical, social, and economic factors thus, management of the disease continues to be a challenge to most physicians. The Philippines is experiencing a surge in cases since 2013. Understanding the local epidemiology of pediatric HIV may reveal opportunities to reduce or eliminate transmission through timely diagnosis. Objective: This study was conducted to identify the features and outcome of children living with HIV in a hospital where a program for HIV treatment and monitoring was implemented. Methodology: Medical records of all children Guidance Intervention Prevention (SAGIP) Unit were reviewed. Data was analysed using descriptive statistics. Results: Thirty pediatric HIV patients were included in the study. The most common mode of acquisition is by sexual transmission (57%) and most patients were male (76%),bisexual (47%), and heterosexual (47%). Weight loss (50%),rash (50%), fever (37%) and cough (37%) were the most common clinical findings. The most common opportunistic infections were tuberculosis (47%) and oral candidiasis (34%). Only 27 of 30 patients were started on antiretroviral therapy within 6 months from diagnosis. One patient showed resistance to a non-nucleoside reverse transcriptase inhibitor (NNRTI). There were 11 children who died of various opportunistic infections and its complications, while 2 were transferred to a different treatment hub after 6 months, and 1 lost to follow-up. Conclusion: Sexual means of HIV transmission among adolescents is evident in this study. Weight loss, cough, rash, fever, and lymphadenopathy are common presenting features. Tuberculosis and oral candidiasis are the most common opportunistic infections and should alert physicians on possible HIV infection. A mortality rate of 37% was noted mostly in the first 6 months of initiating ART treatment.
Eficacia de los inhibidores de ALK en dos casos con evaluación positiva por inmunohistoquímica y negativa por FISH
Authors: Mandó Pablo , Pérez de la Puente Constanza , Rizzo Manglio , Leguina Laura , Salanova Ruben , Powazniak Yanina , Puparelli Carmen , Chacón Reinaldo , Martin Claudio
Published: December 2022

En el carcinoma de pulmón de células no pequeñas (CPCNP), la activación de ALK se produce por la formación de genes de fusión. El perfil clínico donde ocurre con más frecuencia corresponde a pacientes jóvenes, mayormente mujeres, no fumadores, histología de adenocarcinoma y ausencia de mutaciones de EGFR y KRAS. Su presencia se describe en el 3-10% de los CPCNP.

La importancia de la determinación de ALK radica en que identifica un subgrupo de pacientes con un comportamiento biológico diferente, en los cuales el tratamiento con inhibidores específicos, como el crizotinib, ceritinib o alectinib, es más eficaz que los convencionales. Las alteraciones moleculares de ALK pueden identificarse por hibridación in situ (ISH), por inmunohistoquímica (IHQ) y por RT-PCR, aunque el FISH es el procedimiento diagnóstico de referencia a nivel clínico.

Se examinaron 308 casos de CPCNP y se compararon los resultados por FISH e IHQ. De los 8 (3%) identificados con expresión positiva, sólo 6 presentaron el rearreglo de ALK. Se presentan dos casos clínicos con ALK positivo por IHC y FISH negativo, uno presentó respuesta al tratamiento dirigido y otro no. A pesar de que el FISH es el gold standard, se acepta el uso de IHQ ya sea para definir conducta como único test o para screening y ulterior confirmación por FISH en los casos positivos. Estos dos casos con distinta respuesta al tratamiento con IHQ positiva pero FISH negativo, indican la ausencia de pautas, requiriendo de más conocimiento en el futuro para optimizar las conductas médicas.
Análise das propostas de reforma para promoção da igualdade de gênero no Senado Federal do Brasil
Authors: Braga Maria , Castro Leonardo , Sabbag Gustavo
Published: December 2022

O objetivo deste capítulo é analisar as imbricadas relações institucionais que permeiam a entrada de minorias sociais, mais especificamente mulheres, em instâncias representativas, tais como a Câmara dos Deputados e as Assembleias Legislativas estaduais. O trabalho levou em consideração os projetos de lei que estão no Senado e têm como objetivo a mudança do quadro institucional e a ampliação do acesso de mulheres ao cenário político. A partir de um apanhado teórico e empírico produzido nas últimas décadas no Brasil e no mundo, compreende-se que são múltiplos os fatores que afastam essas minorias da representação política, sendo as instituições que balizam esse caminho representadas pelos partidos políticos, pelas regras do processo eleitoral, pela organização interna das Assembleias e do Congresso, entre outros. Nas páginas que se seguem, além do mencionado, serão discutidos o papel dos partidos políticos no processo de seleção de candidaturas dessas minorias, sua capacidade eleitoral e de acesso nas esferas eletivas, seu desempenho parlamentar, assim como o debate sobre como as sete propostas analisadas poderiam mudar o quadro representativo nacional.
Analisis Literasi Keuangan dan Pendapatan Masyarakat dalam Pengelolaan Keuangan Terhadap Keputusan Investasi
Authors: Hafidah Andi
Published: December 2022

Literasi keuangan adalah kemampuan untuk memahami pro dan kontra dari suatu keputusan keuangan, mempertimbangkan biaya dan dengan percaya diri memutuskan apa yang harus dilakukan. Literasi keuangan merupakan salah satu bentuk investasi jangka panjang yang bermanfaat dalam mengelola dan menjaga kondisi keuangan. Penelitian ini merupakan penelitian deskriptif yang bertujuan untuk menjawab permasalahan yang sedang dihadapi dengan mengumpulkan data literasi keuangan bagi masyarakat dalam pengelolaan keuangan agar tidak terjadi kesalahan dalam penggunaan kredit dan tidak adanya perencanaan keuangan. Sampel penelitian adalah 50 responden dari civitas akademika. Metode yang digunakan adalah probability sampling, purposive sampling. Pengumpulan data dilakukan dengan menyebarkan kuesioner melalui Google form. Hasil penelitian menunjukkan bahwa tingkat literasi keuangan dan pendapatan dalam pengelolaan keuangan masyarakat berpengaruh terhadap pengambilan keputusan investasi
Analisis Literasi Keuangan dan Pendapatan Masyarakat dalam Pengelolaan Keuangan Terhadap Keputusan Investasi
Authors: Hafidah Andi , Nurdin Jumiati
Published: December 2022

Literasi keuangan adalah kemampuan untuk memahami pro dan kontra dari suatu keputusan keuangan, mempertimbangkan biaya dan dengan percaya diri memutuskan apa yang harus dilakukan. Literasi keuangan merupakan salah satu bentuk investasi jangka panjang yang bermanfaat dalam mengelola dan menjaga kondisi keuangan. Penelitian ini merupakan penelitian deskriptif yang bertujuan untuk menjawab permasalahan yang sedang dihadapi dengan mengumpulkan data literasi keuangan bagi masyarakat dalam pengelolaan keuangan agar tidak terjadi kesalahan dalam penggunaan kredit dan tidak adanya perencanaan keuangan. Sampel penelitian adalah 50 responden dari civitas akademika. Metode yang digunakan adalah probability sampling, purposive sampling. Pengumpulan data dilakukan dengan menyebarkan kuesioner melalui Google form. Hasil penelitian menunjukkan bahwa tingkat literasi keuangan dan pendapatan dalam pengelolaan keuangan masyarakat berpengaruh terhadap pengambilan keputusan investasi
TVAR-MODELS OF FINANCIAL SECURITY INDICATORS FOR MACROECONOMIC SYSTEMS: IMPACT ASSESSMENT OF ENERGY “SHOCK”
Authors: POLIANSKYI V.
Published: December 2022

The break of connections in economic systems results in imbalance and a theoretical possibility of a threat for their development. This raises the issue of finding an effective mechanism for economic security in general and financial security in particular, which are important elements of how macroeconomic components work. The purpose of the study is to develop models that allow assessing the impact of an energy “shock” on financial security indicators, to identify the threshold values of exogenous variables at which the “shock” has a destructive influence on the level of financial security and can lead to the financial system destabilization. The work uses a branched structure of scientific methods which consist of theoretical and empirical research of the financial security for macroeconomic systems. The main results of this work are devoted to the consideration of the problem of how to design effective mechanisms for ensuring financial security under the conditions of exogenous “shocks” of the global economy. It considers the concept of “shock” and gives the examples of the impact of “shocks” on macroeconomic indicators. The work highlights the energy “shock” as dominant for the analysis and formation of an effective macroeconomic stability policy. The information area of research features is substantiated, including BRENT oil price data and indicators of monetary and currency security, such as the rate of inflation and the exchange rate. Emphasis on subsystems of monetary credit and currency security is made due to the importance of these channels of crisis infection in order to ensure financial security. The value of the lag in the model is substantiated with the help of information criteria; evaluation and testing of the quality of the model have been carried out; system stability has been assessed based on the impulse response function, the TVAR model has been developed. The areas of change of the exogenous variable reflecting the statistically significant impact of the energy “shock” on the rate of inflation are analyzed. Thus, the obtained results made it possible to identify the regimes of energy security, which become a channel of infection of the financial sphere and a significant increase in the level of inflation. Practical significance includes the versatility and applicability of the evaluation approach for research due to the ability to use the entire algorithm as a complete ensemble of models. The results of this material can be used in the formation of government financial security policies and reactions to destabilizing external influences.
STUDY OF STRATEGIES FOR SUSTAINABLE PRODUCTION AND CONSUMPTION IN THE ECONOMIC CONDITIONS OF UKRAINE
Authors: IVASHURA A. , PROTASENKO O. , MYKHAILOVA E. , SEVERINOV O.
Published: December 2022

Modern requirements for companies and consumers include the stability of financial performance amid increasing environmental attractiveness. Companies need to cover such seemingly diverse interests as profitability for owners, concern for staff, interest for partners and consumers, and actions for environmental protection. It is essential to consider the growing role of conscious consumption, which is a direct regulator of production activity. Today, this is especially important for Ukraine, considering its transition to sustainability and the implementation of sustainable development goals in the sphere of sustainable production and consumption. The aim is to formulate a strategy and recommendations for combining sustainable initiatives in production and consumption in the context of European integration processes in Ukraine. The research object is sustainability in production and consumption. The article proposes a strategy combining sustainable production and consumption into one cluster. It will allow sustainable initiatives are focused on systemic changes and essential areas of production and consumption. The work used the method “Sustainable value of the business”. This method includes detailed reporting on the sustainable development of production with relevant ratings and indices. It’s recommended for use in decision-making, investment management for business development, comparative analysis, and communication with stakeholders; it also provides a comprehensive view of the company’s impact on six standardized parameters. The result is a proposal to create an algorithm to combine sustainable production and consumption into one cluster. It will allow sustainable initiatives to focus on systemic changes in crucial production and consumption areas – energy, transport, housing, agriculture, and food. The practical value of the approach is in a strategy that includes measures stimulating environmental and socio-economic policy of production. It will allow moving from relative disunity of actions to technological standards. The proposed approach can be implemented in recommendations for improving programs on changing behavior from a gradual transition from individual consumers to broader initiatives to change the entire system – production and consumption.
Primary aldosteronism: current diagnostic approach
Authors: Eniseeva lena S.
Published: December 2022

Primary aldosteronism is characterized by aldosterone secretion that is independent of renin and angiotensin II. The deleterious effects of primary aldosteronism are mediated by excessive activation of the mineralocorticoid receptor that results in the hypertension, hypokalemia, and it also increases the risk for cardiovascular and kidney disease, as well as death. Current evidence suggests that the prevalence of primary aldosteronism is much greater than previously recognized and milder forms of renin-independent aldosterone secretion may be common. These forms may be missed. This review focused screening in those at increased risk of primary aldosteronism. An approach to evaluating screening results was presented. Family aldosteronism should be considered in young hypertensive patients with a family history of primary aldosteronism. Genetic testing is appropriate in these patients. Careful interpretation of screening data, recent achievements in hormone assays and sampling methods and their clinical relevance are discussed. Confirmatory tests and evaluation of their results are considered. The optimal approach to distinguish unilateral from bilateral primary aldosteronism is by adrenal vein sampling that is the only reliable method to select patients for surgery. More effective strategy to diagnose PA should lead to early detection of PA and could decrease the cardiovascular complications of the patients.
THE ROLE OF GENETICS IN MODERN MEDICINE
Authors:   Irkutsk State Medical University, Tkachuk E.A. , Seminsky I.Zh. ,   Irkutsk State Medical University,   Scientific Centre for Family Health and Human Reproduction Problems
Published: December 2022

The lecture discusses the role of modern genetics and its significance for medicine, determines the goals of genetics and its structure. It is shown that modern medical genetics is divided into general, clinical and laboratory genetics. Other fields of genetics are genomics, molecular and biochemical genetics, cytogenetics, developmental genetics, oncogenetics and immunogenetics, pharmacogenetics, population genetics, ecological genetics, nutrigenetics, toxico-genetics. It is noted that about 20–40 % of clinic patients have hereditary pathology. The main possibilities of modern genetics, such as human genome sequencing, molecular genetic diagnosis of hereditary pathology, personalized medicine, genetic certification, identification of genetic markers for oncological diseases, determination of individual drug sensitivity using pharmacogenetics methods, gene therapy of previously incurable diseases, medical bioengineer-ing and genome editing. The issues of biological aging of the body and the possibility of prolonging active longevity by the methods of modern genetics are discussed. Conclusions are drawn about the need to introduce knowledge, skills and abilities in the field of clinical genetics propaedeutics, genetic testing and interpretation of its results, treat-ment and prevention using modern genetics methods into the system of higher medical education.
Virtual Data Generation for Marine Turbochargers Using GANs
Authors:   Institute of High Performance Computing, A*STAR, Du Chunling ,   Institute of High Performance Computing, A*STAR, Ho Choon Lim
Published: December 2022

A large amount and diversity of data is required for training an effective and robust deep learning or machine learning model. However, obtaining sufficient and various real-time data is difficult for bulky equipment such as marine turbochargers in practical working conditions, since exhaustive acquisition and annotation is hard and time-consuming. In this paper, the proposed methods use Generative Adversarial Networks (GANs) to generate virtual numerical data from limited number of real data. Two GAN architectures, which are basic GAN and conditional GAN, are utilized to develop the methods. The resultant virtual data can be either unlabelled or labelled. It shows that GANs can generate numerical data which is similar enough and not significantly different from the real data. Furthermore, GAN-based domain adaptation approach will be developed to generate synthetic data for predictive maintenance of a turbocharger, given by some healthy data of itself and laboratory testing data of other turbochargers.
Role of Social Studies Teacher to Inculcate Student Character Values
Authors: Miftakhu Rosyad Ali , Sudrajat Jajat , Heng Loke Siow
Published: December 2022

This study aims to investigate the role of social science subject teachers in instilling character values ​​in students through the process of teaching and learning activities. This study used a quantitative approach with a case study type conducted at SMP Muhammadiyah Indramayu. The results of the study show that teachers of the Social Sciences subject at SMP Muhammadiyah Indramayu have tried their best to carry out their duties, especially in instilling historical awareness as well as values ​​of nationalism, identity and character in their students. This is proven when the writer observes while teaching in class being able to use strategies, various methods and modes so that the classroom atmosphere is lively and full of enthusiasm and is able to develop students to think historically analytically with various assignments. Besides that, teachers outside the classroom always monitor the character and attitudes of students to measure the extent to which what has been taught has an effect.
Pengaruh Program Dana Desa Terhadap Perekonomian Masyarakat, Perluasan Lapangan Kerja dan Peluang Usaha Masyarakat Desa (Studi Deskriptif Korelasi pada 10 Desa di Kabupaten Purwakarta)
Authors: Jumiati Eti , Adam Duki
Published: December 2022

Penelitian ini bertujuan untuk mengetahui pengaruh program dana desa terhadap perekonomian masyarakat, perluasan lapangan kerja dan peluang usaha masyarakat Desa di Kabupaten Purwakarta. Metode penelitian yang penulis gunakan adalah analisis Multivariat atau  MANOVA. Fungsi MANOVA adalah untuk megetahui pengaruh secara parsial antara variable program dana desa (X) terhadap variable perekonomian masyarakat (Y1), terhadap perluasan lapangan kerja (Y2) dan terhadap peluang usaha (Y3). Dan untuk mengetahui pengaruh secara simultan antara variable program dana desa (X) terhadap perkonomian masyarakat (Y1), perluasan lapangan kerja (Y2) dan peluang usaha (Y3).Populasi  dalam penelitian ini adalah 10 Desa di Kabupaten Purwakarta, yang masing-masing diambil sebanyak 10 responden. Teknik pengambilan sampel menggunakan teknik sampel acak terstratifikasi (stratified random sampling), yakni mengambil sampel secara acak proposional dari masing-masing Desa.

Hasil penelitian adalah sebagai berikut: 1) berdasarkan test of between effects atau pengaruh variable secara individu, bahwa variable program dana desa masing-masing berpengaruh terhadap pertumbuhan ekonomi, perluasan lapangan kerja dan peluang usaha. Karena seluruh variable nilai signifikansinya > dari 0.05; 2) berdasarkan tes tersebut dinyatakan bahwa secara bersama-sama ada pengaruh program dana desa terhadap pertumbuhan ekonomi, perluasan lapangan kerja dan peluang usaha, karena nilai F hitung > dari F table.
PENERAPAN METODE MIND MAPPING (PETA PIKIR) DALAM PEMBELAJARAN PENDIDIKAN AGAMA ISLAM
Authors: Elvi Rahmi
Published: December 2022

Motivasi adalah salah satu faktor yang sangat penting dalam menentukan keberhasilan belajar peserta didik. Untuk meningkatkan motivasi tersebut guru harus menggunakan berbagai metode dan media belajar yang sesuai dengan materi pelajaran agar peserta didik termotivasi untuk belajar. Namun pada kenyataanya guru masih enggan untuk menggunakan metode-metode dan memanfaatkan media pembelajaran yang ada. Guru kurang kreatif, tidak ada variasi, interaksi guru dan peserta didik kurang, serta kurangnya fasilitas-fasilitas media pembelajaran. Dengan kondisi tersebut maka peserta didik kurang antusias dalam kegiatan pembelajaran, kurang aktif, ide kreatifitas peserta didik kurang tersalurkan, dan tingkat kedisiplinan dalam belajar juga kurang. Penelitian ini bertujuan untuk mengetahui penerapan metode mind mapping (peta pikir) dalam pembelajaran pendidikan agama Islam. Untuk mencapai tujuan tersebut, maka penelitian ini menggunakan pendekatan deskriptif kualitatif dengan teknik pengumpulan data dalam bentuk observasi, wawancara dan dokumentasi. Hasil penelitian menunjukkan bahwa metode mind mapping sangat baik digunakan dalam proses pembelajaran PAI. Disebabkan siswa bisa konsentrasi penuh dalam proses pembelajaran, efesien waktu dapat dilaksanakan, siswa berperan aktif dan guru bisa mengarahkan siswa untuk dapat menemukan hal-hal penting dalam dalam materi pembelajaran, serta siswa merasakan kemudahan dalam belajar dengan menggunakan mind mapping.
ANALISIS PENGEMBANGAN KURIKULUM DI LEMBAGA PENDIDIKAN ISLAM
Authors: Elvi Rahmi
Published: December 2022

Curriculum development in educational institutions is inseparable from various aspects that influence it. The curriculum is an important component in education, because in the curriculum there are all educational processes from planning to implementing evaluations. The curriculum development process is the process of perfecting the existing curriculum. In accordance with the current flow of globalization, curriculum development can be seen from the various supporting and inhibiting factors that influence it. This study discusses the curriculum development process, the stages of curriculum development, and the supporting and inhibiting factors in the curriculum development process. The method used is library research which aims to examine various literatures on curriculum development. The results can find out the curriculum development process carried out to develop the curriculum in Islamic Educational Institutions.
DOE-MARCOS: A new approach to multi-criteria decision making
Authors: Duc Trung , Hong Son , Trung Hieu , Thi Nhu
Published: December 2022

Choosing the best among the available alternatives seems to be expected in all fields. As each alternative is considered by multiple criteria, the selection of the best alternative must take into account all of those criteria. MCDMs are methods that have been widely used to solve problems of this type. However, if only a certain MCDM is applied, the ranking of alternatives must be done from the beginning as adding/removing one or more alternatives from the option list. This paper presents a probably new approach to deal with this situation. DOE method was used in combination with the MARCOS method to build a relationship between the scores of the options and the criteria. This mix is called DOE-MARCOS. Based on this, the calculation of the scores of the alternatives may be faster and less complicated than only using the MCDM. A simple example was made to evaluate the effectiveness of the proposed method when an alternative was added to the list. Two other examples were also conducted to assess the performance of the proposed method (DOE-MARCOS) in ranking cutting tools. The results of ranking options using the DOE-MARCOS are compared with other methods. Sensitivity analysis in each example under different scenarios was also carried out. Its results show that the proposed method is highly effective for multi-criteria decision making.
Diseño de una propuesta de autoevaluación para el desarrollo de la autorregulación en educación superior
Authors: Cabrera Nati , Fernández-Ferrer Maite , Maina Marcelo Fabián , Sangrà Albert
Published: December 2022

La evaluación por competencias en la educación superior es uno de los mayores retos a los que se enfrentan las universidades en la actualidad. Este artículo presenta la evolución de una propuesta metodológica transversal en un programa de máster en línea, para el desarrollo y la evaluación de la capacidad de autorregulación del estudiantado a través de una estrategia de autoevaluación fundamentada y dialogada. Dicha evolución, fruto de una evaluación continuada de la implementación de la propuesta, supone cambios en el planteamiento metodológico inicial y la integración de la tecnología como facilitadora del proceso. Partiendo del concepto de diseño centrado en el estudiantado, se plantea un estudio longitudinal durante tres cursos académicos en el que se recoge de manera sistemática la opinión y percepción del estudiantado y del profesorado del programa. Concretamente, y a través de un análisis de los elementos a mejorar en cada una de las tres fases, se identifican un conjunto de decisiones sobre el diseño original que finalmente ha derivado en la creación e integración de una herramienta ad hoc para la autoevaluación competencial y la autorregulación en un entorno virtual. Las conclusiones del trabajo ponen de relieve la importancia de pensar soluciones de manera integral, atendiendo a la necesidad de proveer un andamiaje al estudiantado para mejorar su capacidad de autorreflexión, de formar al profesorado en el trabajo y evaluación por competencias y de contar con las herramientas adecuadas para sostener dichos procesos.
Roles del docente universitario en procesos de aprendizaje colaborativo en entornos virtuales
Authors: Hernández-Sellés Núria , Muñoz-Carril Pablo-César , González-Sanmamed Mercedes
Published: December 2022

Las instituciones de educación superior se enfrentan al compromiso permanente de formar y acompañar al profesorado en un contexto marcadamente digital que implica una continua adaptación cultural y un compromiso con la innovación en los procesos docentes. El trabajo colaborativo constituye una presencia consolidada en las aulas virtuales que sigue planteando grandes retos a docentes y estudiantes. Este artículo presenta un estudio acerca de las tareas y roles docentes en el trabajo colaborativo en entornos virtuales; identificando su tipología y la importancia conferida por los estudiantes. La investigación se llevó a cabo con 104 alumnos en 5 asignaturas de grado en las que se desarrolló una metodología de trabajo colaborativo en línea. Se utilizó un enfoque cuantitativo basado en el método de encuesta, en el que se emplearon diversos análisis descriptivos y multivariantes. Los estudiantes han valorado como muy importantes todas y cada una de las tareas docentes propuestas para el desarrollo del trabajo colaborativo, destacando aquellas con un componente social y personal. Los resultados obtenidos han permitido identificar un total de siete roles clave que un docente universitario debería desarrollar cuando implementa una metodología de trabajo colaborativo en línea: pedagógico, evaluador, social, tecnológico, orientador/mediador, organizador/gestor y personal. Si bien no todos alcanzan la misma valoración, las puntuaciones obtenidas son muy altas indicando la necesidad de una formación docente específica para asumir las exigencias de una enseñanza en línea y, más específicamente, para afrontar la implementación de las propuestas de aprendizaje colaborativo en entornos virtuales.
Partisan bias in responses to sexual misconduct allegations against male politicians
Authors: Clarke Edward J. R. , Klas Anna , Lizzio-Wilson Morgana , Kothe Emily J.
Published: December 2022

Across two studies, we tested whether evaluations of sexual misconduct allegations against male politicians are made in a partisan biased manner. First, we investigated the likelihood a sexual misconduct allegation made by a female staffer was perceived as legitimate by Democratic and Republican participants when the accused politician’s party affiliation was aligned (versus unaligned) with the participant’s own affiliation (Study 1). We also tested whether partisan bias was conditional on the strength of the participant’s expressive partisanship (Study 2). In Study 1, 182 Democratic and 159 Republican affiliates (N = 341), recruited via Amazon Mechanical Turk, were randomly allocated to one of three conditions (Democratic, Republican, or unaffiliated accused politician). Findings indicated that Republican participants were less likely than Democrats to perceive a sexual misconduct allegation as legitimate, irrespective of the politician’s party affiliation. Nonetheless, participants were not more likely to perceive a sexual misconduct allegation against an unaligned politician as more legitimate than against a politician of their own party. However, in a replication of Study 1 with a larger sample (301 Democratic and 301 Republican affiliates), Republicans (but not Democrats) demonstrated partisan bias in judgements of the legitimacy of misconduct allegations. Expressive partisanship did not moderate this partisan effect.
Cognitive Meaning of Inclusive Education of Students with Disability in Regular Education Teachers
Authors: Morales-Martínez Guadalupe Elizabeth , Mezquita-Hoyos Yanko Norberto , Castro-Campos Claudia
Published: December 2022

Background: Successful inclusive education strongly represents the development of society, promoting better living conditions for students with disabilities.

Objective: This study explored the mental representation of knowledge of inclusive education and disability held by regular education teachers with experience in this field.

Methods: First, participants performed a conceptual definition task through the Natural Semantic Networks technique. Teachers defined ten target concepts related to the cognitive schema of inclusive education. They had 60 seconds to define each target, using verbs, adjectives, nouns, and pronouns, after rating the definers’ quality to conceptualize the target. Subsequently, the authors implemented a constraint satisfaction neural network to simulate the school inclusion schema's behavior and carried out a chronometric cognitive analysis using data from the first study.

Results: Participants organized the educative inclusion meaning on four dimensions (definition, actors' qualities, stakeholders, and inclusion program effects). However, some concepts about school integration and conventional education appeared in the educative inclusion schema. Further, computer simulations showed that participants seem to have an internal locus of control over inclusive actions. Generally, experience with students with disabilities promotes the formation of a favorable educational inclusion schema. However, even though participants in this study have experience in inclusion programs, they are still constructing the inclusive education schema.

Conclusion: The cognitive evaluation provides useful information to empower teachers to be aware of their knowledge and biases on inclusive education and the importance of their work in the success of school inclusion programs.
Structure-guided isoform identification for the human transcriptome
Authors: Sommer Markus J , Cha Sooyoung , Varabyou Ales , Rincon Natalia , Park Sukhwan , Minkin Ilia , Pertea Mihaela , Steinegger Martin , Salzberg Steven L
Published: December 2022

Recently developed methods to predict three-dimensional protein structure with high accuracy have opened new avenues for genome and proteome research. We explore a new hypothesis in genome annotation, namely whether computationally predicted structures can help to identify which of multiple possible gene isoforms represents a functional protein product. Guided by protein structure predictions, we evaluated over 230,000 isoforms of human protein-coding genes assembled from over 10,000 RNA sequencing experiments across many human tissues. From this set of assembled transcripts, we identified hundreds of isoforms with more confidently predicted structure and potentially superior function in comparison to canonical isoforms in the latest human gene database. We illustrate our new method with examples where structure provides a guide to function in combination with expression and evolutionary evidence. Additionally, we provide the complete set of structures as a resource to better understand the function of human genes and their isoforms. These results demonstrate the promise of protein structure prediction as a genome annotation tool, allowing us to refine even the most highly curated catalog of human proteins. More generally we demonstrate a practical, structure-guided approach that can be used to enhance the annotation of any genome.