bluuebunny/crossref_metadata_2025 huggingface dataset:
The little-known architectural heritage of Vasily Krichevsky: features of research, preservation and restoration
Authors: Vitchenko Denуs
Published: August 2023

In article is devoted to the architectural work of Vasyl Krychevsky – an outstanding Ukrainian architect, artist, art critic and teacher of the late 19th – first half of the 20th century. The founder of the new Ukrainian architecture with a pronounced national identity. A detailed analysis of publications devoted to the architectural work of Krichevsky is given. The article highlights two periods of the architect's creativity according to the degree of creative freedom and four periods of creativity according to the place of stay and activity. In the period of the creative development of the architect, three architectural workshops were identified, in which Krichevsky gained experience in life and honed his skills. The style of architectural objects at different periods of Krichevsky's work is characterized. Seven main prerequisites for the architect's form-building searches have been identified. The author's terminology has been introduced to designate the tools of shaping an architectural object with signs of Ukrainian traditional originality – "patterns of Ukrainian originality", which include "patterns of form" and "patterns of morphogenesis". And also "new creation" - a new architectural object, which is the result of the use of "patterns of form" with the help of "patterns of morphogenesis". The evolution of the architectural image of objects by Krichevsky in the direction of functionality and rationality, which took place in 1920-1930, is noted. under the influence of social and political changes. The little-known architectural objects by Vasil Krichevsky are highlighted, the features of their study are revealed, the ways of their preservation, restoration and restoration are outlined. A graphic reconstruction of the facades of the Vasil Krichevsky mansion in Kharkov is presented - the only architectural object in Ukraine, which was designed by Krichevsky and belonged to his family. The importance of publications about the architect for involving the public in the preservation and restoration of the little-known architectural heritage of Vasil Krichevsky was noted.
Expected Macroeconomic Effects of Issuing a Retail CBDC
Authors: Martínez-Ventura Constanza , Parra-Polania Julián A. , Mora-Arbeláez Tatiana , Lizarazo-Cuéllar Angélica
Published: August 2023

This document reviews the potential macroeconomic effects of issuing a central bank digital currency (CBDC) for the use of individuals and businesses. A careful selection of the architecture, and the economic and technological design aspects of this digital form of central bank money that best suit the needs of Colombian economy is made to frame the analytical approach used to study these issues. The most salient results of the related literature are reviewed to establish the consequences of undertaking this initiative. For the set of selected assumptions, we find that the expected macroeconomic consequences are negligible.
Caracterización de la oferta y demanda de trabajo en la Región Caribe
Authors: Otero-Cortés Andrea , Villegas Mendoza Alexander , Álvarez Vos Oriana , Acosta Karina
Published: August 2023

Los mercados laborales locales en Colombia son heterogéneos y con importantes diferecias geográficas. En las ciudades de la región Caribe coexisten una alta informalidad laboral y relativamente bajas tasas de desempleo en comparación con el resto del país. Este trabajo ahonda en las características de la oferta y demanda en el mercado de trabajo en el caribe colombiano y se estima la curva de Beveridge para tener una primera aproximación al potencial desequilibrio existente. Este estudio identifica dos factores que pueden ser los causantes de los resultado de equilibrio general particulares que se observan en la región. Por el lado de la demanda, se encuentra una menor creación de vacantes formales en el Caribe, laboral y, por el lado de la oferta, se documentan fallas en calidad y pertinencia de la educación de la fuerza laboral regional. Ambos factores en conjunto pueden explicar el menor dinamismo del mercado laboral del Caribe, que conlleva a diferencias en los indicadores laborales de las ciudades capitales de esta región versus el resto de las áreas metropolitanas del país.
Funcionamento de um Laboratório Regional Diante das Necessidades Locais
Authors: Mélo Homero Cavalcante
Published: August 2023

Procura-se justifícar a implantação de Laboratórios Regionais de Física em Radioterapia, em regiões onde haja deficiência de físicos especializados, estabelecendo-se as suas responsabilidades e metas de atuação. Citam-se, ainda, os equipamentos necessários para sua existência como tal, e as dificuldades em sua implantação. Finalmente, são apresentadas detalhadamente as atuações do Laboratório Regional do Nordeste.
ТЕОРЕТИКО-НОРМАТИВНІ ОСНОВИ ФОРМУВАННЯ КОМПЕТЕНЦІЙ МАЙБУТНЬОГО ВЧИТЕЛЯ ПОЧАТКОВИХ КЛАСІВ
Authors: РАДЮК Інна
Published: August 2023

У статті здійснено аналіз теоретичних засад та наукових розвідок з питання професійної компетенції вчителя початкових класів в контексті сучасних вимог щодо професійної підготовки. Проаналізовано ключові підходи до визначення понять «професійна педагогічна компетентність», «компетентність» і «компетентнісний підхід» у науково-педагогічній, довідково-енциклопедичній літературі та нормативних документах, висвітлено їх сутність та переосмислення розуміння в процесі змін ціннісних орієнтацій та зародження нових освітянських навиків. Поняття компетентності потрактовано як здатність ефективно вирішувати професійні завдання, що вимагає наявності сформованих знань, умінь, навичок, досвіду. Вона виявляється у практиці професійної діяльності як системна характеристика і має чітко визначені зміст і структуру. Акцентовано увагу на тому, що практичні проблеми формування загальних та спеціальних компетенцій потребують роз’яснення. Освітній процес сьогодні ґрунтується на засадах педагогіки партнерства, співпраці між суб’єктами і об’єктами навчання, відходу від репродуктивної моделі опанування знань, що вимагає переформатування змістового та методичного наповнення. Значну увагу автором приділено висвітленню означеної проблеми у нормативних документах, зокрема, у стандарті вищої освіти. Схарактеризовано основні спеціальні компетентності, визначені стандартом вищої освіти галузі знань Освіта, педагогіка за спеціальністю Початкова освіта, формування яких визначає змістове наповнення освітнього процесу. Запропоновано механізм реалізації компетентнісного підходу та його безпосереднього впровадження в освітній процес шляхом відображення та врахування програмних результатів навчання, спеціальних компетенцій, передбачених стандартом вищої освіти, при розробці робочих програмам, силабусів та їхньому тематичному плануванні.
ФОРМУВАННЯ ГРАФІЧНИХ І ТЕХНІЧНИХ НАВИЧОК ПИСЬМА ПЕРШОКЛАСНИКІВ
Authors: СІРАНЧУК Наталія , ДУБОВИК Світлана
Published: August 2023

У статті висвітлено основні аспекти формування графічних і технічних навичок письма першокласників. Розкрито зміст кожного етапу формування графічних навичок у підготовчий період навчання письма. Визначено роботу у зошитах без сітки зошита над сприйманням форми фігури, графічного елемента, де пропонується зображення різноманітних ліній окремо та в поєднанні. Репрезентовано роботу у зошитах без сітки, наприклад обведення трафаретів, поєднання крапок у фігурі, штрихування. Визначено роботу у сітці зошита, наприклад письмо ліній, схожих на елементи букв. Окреслено роботу в неповній сітці зошита – написання в основному рядку, в рядку, що доповнюється міжрядковою лінією та висвітлено роботу в повній сітці зошита. У процесі спостереження за навчанням першокласників писати встановлено, що у підготовчий період більшість із них роблять сильний натиск на папір під час штрихування й розфарбовування фігур та при письмі в рядку. Це відбувається тоді, коли учні не засвоїли форму елемента літери, графеми, послідовність написання. Учні не можуть скоординувати рух руки і гальмують його під час переходу на інший напрям або для штрихування подаються замалі або завеликі фігури чи є механічні перешкоди. У статті висвітлено деякі види графічних помилок, яким можна запобігти чітким поясненням завдання, вчасним виправленням помилки, умінням визначити час для свого класу на суто графічні дії. Важливе значення приділяється «письму» у повітрі. Установлено, що результативним є доцільно використане письмо під такт, яке змушує уважно слідкувати за виписуванням елемента літери, а також позитивно впливає на формування охайності, плавності письма.
Representations of Stalin in Characters’ Dreams According to Zaira Arsenishvili's Prose
Authors:   Ilia State University, Katamadze Ketevan
Published: August 2023

The aim of the article is to show how the trauma caused by the Stalinist regime reflected on the human unconscious in Post-Soviet Georgian literature. The issue, which had not been the subject of special research before, was analyzed according to three prose texts by the modern Georgian writer Zaira Arsenishvili (1933–2015): "Requiem for Bass, Soprano and Seven Instruments or a Portrait of a Young Writer", “Oh, World!", and "When Fear and Trembling are Raging". The theories of trauma and possible worlds were taken as the general context of the research, and, while conceptual metaphor is used as a specific, data diagramming is used as the main method. The study showed that the Georgian literary dreams of Soviet reality reflect the difficult political and social situation of 20th century Georgia; representing Stalin as a dictator and revealing the psychological trauma caused by the Soviet regime.
Determination of Urban Public Transport Demand by Processing Electronic Travel Ticket Data
Authors: Fadeev Aleksandr I. , Alhusseini Sami
Published: August 2023

Determination of transport demand is one of the key factors to solve many transportation problems. Existing methods for obtaining information about passenger mobility have significant shortcomings; currently, methods based on the collection, integration and analysis of big data (Urban computing, big data) are being increasingly used.Within the framework of this approach, a methodology has been developed for determining the passenger traffic by public transport from the operations of validating electronic travel tickets: smart cards, transport cards, magnetic cards, mobile phones or other electronic devices (Electronic Gadgets), their details are recorded in the Automated Fare Collection (AFC).In this work we have taken into account that the passenger can travel one, two or more segments before paying for the trip. On some routes, payment is made at the end of the trip.The article presents a methodology based on defining and evaluating the set of acceptable variants of the connectedness of the passenger trips' sequence, which takes into account many factors that influence the choice of travel routes by the passenger. For example, unlike existing solutions, the possibility of paying for travel at any point of the route is taken into account, not necessarily immediately after boarding the vehicle.Approbation of the considered methodology was carried out on the data of the Krasnoyarsk public transport system for April 2019. It has been proved that passenger traffic from the validation of electronic travel tickets allows us to estimate the parameters of public transport demand within the limits of acceptable statistical errors.
Challenges and opportunities of the transformation of the economy of education in the model of post-war reconstruction of Ukraine
Authors: Tkachenko Olena , Kozlovska Larisa , Lisniak Natalia
Published: August 2023

The article is devoted to the evaluating of prospects for the Ukrainian education economy qualitative transformation in the process of postwar recovery. In particular, the propensity of the Ukrainian population to invest in raising the level of education is assessed and the preferences for educational formats are specified, as an important prerequisite for updating the structure of higher education’s funding sources and the relative system of motives and incentives to increase its economic efficiency. The initial information was obtained based on the results of a sample survey conducted among the population of Ukraine affected by the war. The theoretical basis of the work was researches devoted to determining the role of the accumulation of human capital in the processes of expanding and updating the structure of national production.
A high potential of expanding the solvent demand for short-term training programs, which will be provided with the active participation of potential employers, has been revealed, because 33.0% of the total number of respondents plan to change their profession, which mainly causes additional demand for educational services.
Grouping and categorizing library services at the official websites of central libraries of RF constituent territories: The need for standardized diversification
Authors: Gendina N. I. , Kolkova N. I. , Ryabtseva L. N.
Published: August 2023

In the context of evolving digital environment, the authors point out the urgency of developing the library services classification, friendly to the users whose needs are satisfied primarily via the library websites.

The findings of the study conducted in 2021–2022 on positioning of the services of the central libraries of 77 subjects of the Russian Federation on their official websites are discussed. The evidence is provided that information about services is often scattered across different website headings and subheadings, and there are no hyperlinks between them. The biased nature of structuring classifications of services, that are not comparable one with another and often confusing, is also emphasized.

The barriers that prevent the prompt search for information about library services on official websites are specified: i. e. the absence of “Services” heading linking users to the entire range of library services, scattered information about services under different headings with no hyperlinks, lacking rubricated lists of services and price lists, irrelevant prices, etc.

The authors suggest that one of the most promising areas of theoretical research is the development of linguistic tools that enable structuring and ordering of information about services, in particular, building rubricators of charged and free services, designing “aspect grids” to allow formalization and uniformness of characteristics of the most important headings on the official websites; and building unified lists of normalized lexical units for wording of headings on the library websites.

The need for unified approaches to presenting the results of the activities of the central libraries of the subjects of the Russian Federation in providing services to users (in particular, remote ones) on official websites is substantiated.

The authors argue that it is the standardized diversification that will allow the services to be adequately positioned on the official websites of libraries. This will enable to provide full representation of multiaspect library activities, to increase library competitiveness and to ensure the growth in the number of physical visits and online users.
Verification of classification modernization solutions (the case study of Library Bibliographic Classification)
Authors: Golodnova N. N. , Pivovarova M. A.
Published: August 2023

Efficiency of library classifications depends on their capacity to embrace current knowledge and social practices. Therefore, the verification (late Latin verificatio – evidence, confirmation, from the Latin verus – true and facio – to make) of upgrade solutions is an essential part of classification system operation and development. The problem of library classification verification is often out of researchers view. The verification mechanism (tools) for upgrade solutions has not been described yet. Therefore, the reliability and relevance of classification upgrade solutions is of scientific and practical value.

The purpose of the paper is to summarize the related experience of Research LBC Center of the Russian State Library. Based on s tructured system analysis and the long practice of LBC development and application, the authors examine the mechanism for monitoring publications and identifying innovations, including new terms, concepts, social phenomena, etc., and for assessing and processing data for continuing update of the classification system. Using the example of LBC modernization solutions, the authors discuss advantages and disadvantages of individual methods. They conclude that the classification upgrade verification – essential to the nature of the library classification systems – has to become the key element of the classifying culture. The researchers review and suggest the ways to improve the verification mechanism adopted at the RSL LBC Research Center. The integrated approach to LBC verification is of applied relevance both for the theory of classifications and librarianship.
Risk Factors of Infection and Transmission of Viral Hepatitis B and E
Authors: Osadolor Aisosa J , Osadolor Owens O , Osadolor Obehi O
Published: August 2023

Viral hepatitis is a disease burden in Africa and globally. It can be caused by RNA or DNA virus, which is hepatotropic and can pose a financial burden on the individual, their family, and society. Hepatitis B virus (HBV) is a DNA virus that can be present in blood and body fluids, including saliva, semen, and vaginal secretion. It is par-enterally transmitted with horizontal and vertical transmission. The risk of infection and transmission of hepatitis B virus infection could be a result of occupational exposure, use of unsterilized blades for traditional and cultural practices in Africa like tribal marks, level of awareness on prevention and adherence to standard or universal precautions. The risk of infection and transmission of hepatitis B virus infection also includes individual sexual history, the availability and access to vaccines, the level of occupational hazards exposure,  the level of vaccine acceptance and the vaccination status of individuals. Hepatitis E virus (HEV) is a single-stranded RNA virus that is transmitted through the faeco-oral route by consumption of contaminated food and water. Low socio-economic status, poor environmental sanitation, poor water supply, poor sewage disposal facilities, level of awareness on prevention, poor social condition and decreased personal hygiene are associated factors for the risk of hepatitis E virus infection. Knowledge and community-based awareness and practice of World Health Organization (WHO) preventive practices and treatments could reduce the burden of hepatitis B and E virus infections.
Mediscope 2023;10(2): 89-92
Women Entrepreneurship Development through ICT in Developing Countries: Problems & Prospects
Authors: Lutfunnahar
Published: August 2023

It is widely known that women’s economic empowerment can lead to economic growth. Information communication technologies (ICTs) have been promoted as tools for national development. In this context, women have been promoted themselves as entrepreneurs through connecting more people by using ICT tools effectively. This paper mainly focuses on the role of ICT for women entrepreneurship development in Bangladesh. It also represents different social, cultural barriers women face in using ICTs in their business purposes. To make the study more effective questionnaire method was used. For this study 100 women have been selected from different online business pages and sent them the questionnaire. Among them 20 women entrepreneurs respond the questionnaire which included questions on role of ICT, training on ICT, mostly use of device, monthly income, availability of ICT institutions, access of ICT, barriers of using ICT and so on. It is argued in the study that women are becoming adapt themselves with technology especially in their business purpose and lead to contribute to the country’s economy. Lack of awareness, social, cultural structure are the major barriers to bring them as entrepreneurs and change their life.
Social Science Review, Vol. 39(3), Dec 2022 Page 17-35
USE OF ARTIFICIAL INTELLIGENCE IN HEALTH SERVICES MANAGEMENT IN TÜRKİYE
Authors: AK Sebla
Published: August 2023

With the inclusion of technological developments in the health sector, the importance given to artificial intelligence in the field of medicine is increasing. For the future, the application possibilities of artificial intelligence and especially the potential of big data are quite large. There are many uses for artificial intelligence applications in health services, such as surveillance systems, epidemiological analysis, detection of health risks, early diagnosis of diseases, epidemic management and vaccine studies. In addition, there are some potential positive and negative consequences of integrating artificial intelligence into modern medicine. The purpose of this review is to provide information about the concept of artificial intelligence and to evaluate the usage areas, potential benefits and aspects of artificial intelligence in Health Services from a perspective perspective through various application examples.
DETERMINATION OF UNIVERSITY STUDENTS’ HPV KNOWLEDGE LEVELS AND THE AFFECTING FACTORS: A SAMPLE OF NORTHERN CYPRUS
Authors: PEKDEMİR Derya Gülin , MAMUK Rojjin
Published: August 2023

Human Papilloma Virus (HPV), infecting millions of men and women every year, is one of the most common STDs causing high mortality and morbidity rates. This study aims to determine university students’ Human Papilloma Virus knowledge levels and the affecting factors. The descriptive and cross-sectional study was conducted with a sample of 369 students who were enrolled in the Turkish undergraduate and associate degree programs at a university in Northern Cyprus and met the research criteria. Data were collected through the Personal Information Form and the Human Papilloma Virus Knowledge Measure (HPV-KM). Of all the students 47.7% were aged 18-21 years, 50.1% were women, and only 1.1% had been vaccinated against HPV. The total mean score obtained from the HPV-KM was found 19.11±42. Factors affecting the HPV-KM scores were found as age (p=0.000), income level (p=0.000), place of living (p=0.000), family structure (p=0.000), program enrolled (0.000), parents’ education level (p=0.000), parents’ working (p=0.000), smoking (p=0.000), using alcohol (p=0.000), being sexually active (p=0.000), and knowing about sexually transmitted diseases (p=0.000). Students have an above-average HPV knowledge level and several socio-demographic factors affect the HPV knowledge level. HPV vaccination rates are quite low.
Review of the Biological Activity of Rutin: Antidiabetic, Antioxidant, Anti-inflammatory and Antitumor
Authors: Bidzhieva A. , Chiriapkin A.
Published: August 2023

Various parts of plants have long been widely used for the treatment and prevention of diseases. They are a valuable source of biologically active compounds, especially they are rich in polyphenolic structures. Rutin belongs to the group of some of the most common flavonoids in plant objects. Animal organisms do not have enzyme systems for its synthesis, so it enters the human body only with plant food. Rutin is widely used as a component in herbal medicines, multivitamin preparations, in the cosmetology, food and chemical industries. This article discusses the biological activity of rutin, namely antidiabetic, antioxidant, anti-inflammatory and antitumor activity. The article summarizes the current data on the above-mentioned types of biological activity. It follows from the presented research results that rutin is a promising compound with multi-target activity for the treatment of various diseases. It can serve as a basis for the creation of new highly effective pharmacological molecules based on it.
Some Issues of Countering Criminal Offenses in the Field of Informatization and Communications in the Republic of Kazakhstan
Authors: Kalguzhinova A. , Mashabaev A. , Ozbekov D.
Published: August 2023

According to official statistics, in recent years there has been an increase in the registration of crimes that have a pronounced «intellectual» character. The objectively recorded growth of criminal encroachments using information technology dictates the urgent need for theoretical research and generalization of law enforcement practice. The authors made an attempt on the basis of the integrated use of historical and statistical methods to show the impact of improving the substantive criminal legislation on the state of investigative and judicial practice in cases of criminal offenses in the field of informatization and communications. The history of the regulation of responsibility for cybercrime in the criminal laws of sovereign Kazakhstan is traced. As possible ways to increase the effectiveness of countering crimes committed using information systems, the authors formulated proposals to change the form of statistical reporting.
Some Problems of Realization of a Pre-emptive Right to Purchase a Share in General Share Property
Authors: Ablyatipova N. , Slyusarchuk K.
Published: August 2023

The article analyzes certain problems of exercising the pre-emptive right to purchase a share in the right of common shared ownership. It has been established that the law does not provide for the regulation of the issue of exercising the right to pre-emption if several owners of common shared property are ready to acquire the alienated share at the same time. In the process of analyzing the registration of transactions in which there is an element of the pre-emptive right to purchase a share, the author identified problems that are typical both for a notary when registering transactions and for the seller of the corresponding share. Based on the results of the study of the norms of the current legislation, the established law enforcement practice, the authors developed recommendations on introducing a number of changes to the legislation that will streamline and improve the regulation of the pre-emptive right to purchase.
Formalization of Prosecutorial Supervision and Atrophy of the Real Human Rights Functions of the Prosecutor’s Office, Including the Fight Against Corruption in Law Enforcement Agencies, in the Kyrgyz Republic as a Result of the Deprivation of the Prosecutor’s Office of the Authority to Investigate Criminal Cases in 2023
Authors: Imankulov T.
Published: August 2023

The need to leave the authority to investigate malfeasance with the prosecutor's office of the Kyrgyz Republic, the relevance of other legislative initiatives on the reform of law enforcement agencies, as well as the need for laws in the field of counteracting the promotion of non-traditional sexual relations, since propaganda is gaining momentum in the Kyrgyz Republic more and more every day , including the veiled one, especially through social networks, sexual perversions, gender reassignment, pedophilia, propaganda of everything that destroys a person in all respects. Based on the speech of the President of the Kyrgyz Republic in honor of the 30th anniversary of the Constitution of the Kyrgyz Republic on May 5, 2023, the main threats to the Kyrgyz statehood and national security are named. Under such circumstances, today's legislative initiatives to exclude investigative functions from the prosecutor's office in the absence of any need justified by objective indicators and without an objective analysis of the activities of the investigative work of prosecutors are perceived as an attempt to sabotage the constitutional institution, designed to protect the rights and protected by law. interests of citizens, society and the state.
Defects in Legislative Technique, Inflation of Legal Matter, ‘Darkness of the Law’ When Amending and Supplementing the Constitutional Law of the Kyrgyz Republic “On the Prosecutor’s Office of the Kyrgyz Republic” in 2023
Authors: Imankulov T.
Published: August 2023

Based on the analysis of references-justifications to the draft laws of the Kyrgyz Republic “On Amendments to the Criminal Procedure Code of the Kyrgyz Republic” and “On Amendments to the Constitutional Law of the Kyrgyz Republic “On the Prosecutor’s Office of the Kyrgyz Republic”, the author comes to the conclusion that they contradict the Constitution of the Kyrgyz Republic, the recommendations of the Venice Commission of 2021, the international obligations of the Kyrgyz Republic, create a conflict of interest, critically weaken the prosecutor’s office as almost the main supporting structure of the Kyrgyz statehood. At present, the author proposes, on the contrary, to strengthen the prosecutor’s office based on the experience of the Soviet law on the USSR prosecutor’s office for the effective implementation of the human rights functions assigned to the prosecutor’s office.
Shaping Costumes From Laces on the Fibonacci Numbers Basis
Authors: Zelenova Yu. , Zelenova N.
Published: August 2023

Thanks to the large-scale development of technological processes in the fashion industry, favorable opportunities are created for experimenting with the textures and textures of suits, as well as the suit models themselves. Lace, being part of the traditional culture of many countries and peoples, is still perceived by most people as an authentic material with which it is impossible to make any changes in order to avoid the destruction of traditions. The authors of the study Zelenova Yu. and Zelenova N. the goal was to improve the technology of creating lace and approaches to designing suits from lace, which will change the attitude towards lace among professionals and admirers of the fashion industry. The objectives of the study included the study and application of mathematical laws in the artistic design of lace costumes, which are always justified in terms of rational production and positive perception by consumers. Successful and popular costume models are always designed based on the mathematical proportions of the golden ratio. In our study, the golden section ‘Fibonacci series’ is used, with the help of which lace modules were developed, from which costumes were created in the Ariadne author’s lace collection (authors Zelenova Yu., Zelenova N., 2017-2019). The modular technique, on the basis of which the Ariadne author’s collection was developed, allows you to create various lace textures and forms of lace suits, achieving an unlimited variety of combinations from a small number of options. Thus, the modular technique for designing lace suits underlies the transformative shaping of lace suits, which is the most promising direction for the development of the use of lace in a suit in the near future.
Speech Manipulation: Spanglish as a Tool of Speech Impact
Authors: Yartseva S.
Published: August 2023

The article deals with speech impact, in particular, speech manipulation. Various approaches to the definition of manipulation in the language are being analyzed, manipulative techniques are being defined. As an example, for the analysis of the impact, a linguistic phenomenon is taken, which, in fact, is not manipulative, but is involved in advertising activities to influence English and Spanish-speaking consumers, namely Spanglish. It is being analyzed how the phenomenon of Spanglish is actively used in the advertising field to influence the addressee, and what manipulative techniques are applied.
The Concept of kut / well-being in the Kyrgyz and English Language Pictures of the World (Based on the Works of Zhusup Balasagyn Kut Alchu Bilim and Ernest Hemingway The Old Man and the Sea)
Authors: Saipova G. , Alimbekova E.
Published: August 2023

The relevance of the research is due to the growing interest in studying the concept of kut / well-being in the Kyrgyz and English language pictures of the world based on the works of Zhusup Balasagyn Kut Alchu Bilim and Ernest Hemingway The Old Man and the Sea. The novelty of the research lies in the fact that the concept of kut / well-being is considered in a comparative analysis of the use of this concept in these works. A comparative analysis of the concepts revealed differences and similarities in the interpretation and perception of this concept in the Kyrgyz and English cultures. The authors of the article compare various aspects of the concept of kut / well-being, such as its meanings, associations and usage examples. In the course of the study, the authors come to the conclusion that the concept of kut / well-being has similar meanings and associations in Kyrgyz and English cultures, its use may differ in different contexts. In the works of Zhusup Balasagyn and Ernest Hemingway, this concept plays an important role and helps to understand the values and cultural specifics of both peoples. The results of the study can be useful for understanding the differences and similarities between cultures, and also expands our understanding of the concept of kut / well-being in Kyrgyz and English cultures.
MicroRNA-mediated translational pathways are regulated in the orbitofrontal cortex and peripheral blood samples during acute abstinence from heroin self-administration
Authors: Zanda Mary Tresa , Saikali Leila , Morris Paige , Daws Stephanie E.
Published: August 2023

Opioid misuse in the United States contributes to >70% of annual overdose deaths. To develop additional therapeutics that may prevent opioid misuse, further studies on the neurobiological consequences of opioid exposure are needed. Here we sought to characterize molecular neuroadaptations involving microRNA (miRNA) pathways in the brain and blood of adult male rats that self-administered the opioid heroin. miRNAs are ∼18–24 nucleotide RNAs that regulate protein expression by preventing mRNA translation into proteins. Manipulation of miRNAs and their downstream pathways can critically regulate drug seeking behavior. We performed small-RNA sequencing of miRNAs and proteomics profiling on tissue from the orbitofrontal cortex (OFC), a brain region associated with heroin seeking, following 2 days of forced abstinence from self-administration of 0.03 mg/kg/infusion heroin or sucrose. Heroin self-administration resulted in a robust shift of the OFC miRNA profile, regulating 77 miRNAs, while sucrose self-administration only regulated 9 miRNAs that did not overlap with the heroin-induced profile. Conversely, proteomics revealed dual regulation of seven proteins by both heroin and sucrose in the OFC. Pathway analysis determined that heroin-associated miRNA pathways are predicted to target genes associated with the term “prion disease,” a term that was also enriched in the heroin-induced protein expression dataset. Lastly, we confirmed that a subset of heroin-induced miRNA expression changes in the OFC are regulated in peripheral serum and correlate with heroin infusions. These findings demonstrate that peripheral blood samples may have biomarker utility for assessment of drug-induced miRNA pathway alterations that occur in the brain following chronic drug exposure.
Gait and balance in cervical dystonia and dystonic head tremor
Authors: Wagle Shukla Aparna , Gurrala Anjela , Vedam-Mai Vinata
Published: August 2023

Background: Previous studies have found gait and balance abnormalities in patients with cervical dystonia. However, the characteristics of gait and balance in cervical dystonia with head tremors have not been ascertained. A midline constant head tremor when walking would likely render gait and balance more difficult. The pathophysiology of dystonia has also been increasingly linked with cerebellar function abnormality, commonly implicated in gait and balance disorders.

Methods: We examined the gait and balance characteristics of cervical dystonia presenting with head tremors. We used the timed up-and-go (TUG) walk test, 10 m walk test, Berg Balance Scale (BBS), and Gait and Freezing questionnaire. We then assessed the gait on an instrumented walkway system to capture spatiotemporal measures such as speed, cadence, step time, step length, stride width, swing%, stance%, single support%, double support%, and gait variability index (GVI). We also assessed whether the gait in dystonic tremor (DT) differed from essential tremor (ET) and orthostatic tremor (OT), as these tremor disorders share the cerebello-thalamo-cortical pathway as the common pathological pathway.

Results: 50 participants comprising DT (20 patients), ET (15 patients), and OT (15 patients) were enrolled. While the gait abnormalities were subclinical, 11/20 DT patients (55%) walked at a slower speed on the TUG, 11/20 (55%) had reduced scores on the BBS, 9/20 (45%) had increased step time, 4/20 (20%) had reduced step length, 4/20 (20%) had wider stride width, 9/20 (45%) spent greater time during double support and 8/20 (40%) patients had an abnormal GVI. Comparisons of DT with healthy control data revealed a slower gait velocity (p = 0.001) and a reduced step length (p = 0.001). Compared to DT, the ET group revealed a reduced cadence (p = 0.04) and the OT group revealed an increased TUG time (p = 0.03), reduced BBS scores (p = 0.02), reduced step length (p = 0.02), reduced cadence (p = 0.03), reduced GVI (p = 0.01), and increased double support phase (p = 0.045).

Conclusion: DT is accompanied by multiple abnormalities affecting gait and balance, albeit subclinical and less pronounced than ET and OT, possibly related to more effective compensatory mechanisms. Nevertheless, these abnormalities indicate that rehabilitative measures warrant consideration when managing in clinical settings.
Analysis of the interferon-γ-induced secretome of intestinal endothelial cells: putative impact on epithelial barrier dysfunction in IBD
Authors: Naschberger Elisabeth , Flierl Christian , Huang Jinghao , Erkert Lena , Gamez-Belmonte Reyes , Gonzalez-Acera Miguel , Bober Magdalena , Mehnert Martin , Becker Christoph , Schellerer Vera S. , Britzen-Laurent Nathalie , Stürzl Michael
Published: August 2023

The development of inflammatory bowel diseases (IBD) involves the breakdown of two barriers: the epithelial barrier and the gut-vascular barrier (GVB). The destabilization of each barrier can promote initiation and progression of the disease. Interestingly, first evidence is available that both barriers are communicating through secreted factors that may accordingly serve as targets for therapeutic modulation of barrier functions. Interferon (IFN)-γ is among the major pathogenesis factors in IBD and can severely impair both barriers. In order to identify factors transmitting signals from the GVB to the epithelial cell barrier, we analyzed the secretome of IFN-γ-treated human intestinal endothelial cells (HIEC). To this goal, HIEC were isolated in high purity from normal colon tissues. HIEC were either untreated or stimulated with IFN-γ (10 U/mL). After 48 h, conditioned media (CM) were harvested and subjected to comparative hyper reaction monitoring mass spectrometry (HRM™ MS). In total, 1,084 human proteins were detected in the HIEC-CM. Among these, 43 proteins were present in significantly different concentrations between the CM of IFN-γ- and control-stimulated HIEC. Several of these proteins were also differentially expressed in various murine colitis models as compared to healthy animals supporting the relevance of these proteins secreted by inflammatory activated HIEC in the inter-barrier communication in IBD. The angiocrine pathogenic impact of these differentially secreted HIEC proteins on the epithelial cell barrier and their perspectives as targets to treat IBD by modulation of trans-barrier communication is discussed in detail.
Catheter ablation of concomitant atrial fibrillation improves survival of patients undergoing transcatheter edge-to-edge mitral valve repair
Authors: Ausbuettel Felix , Barth Sebastian , Chatzis Georgios , Fischer Dieter , Kerber Sebastian , Mueller Julian , List Stephan , Halbfass Philipp , Deneke Thomas , Nef Holger , Mueller Hans-Helge , Divchev Dimitar , Schieffer Bernhard , Luesebrink Ulrich , Waechter Christian
Published: August 2023

Background

Atrial fibrillation (AF) is the most common concomitant disease in patients undergoing transcatheter edge-to-edge repair (TEER) for mitral regurgitation (MR) and detrimentally affects their outcome. While there is increasing evidence for prognostic improvement and safety of catheter ablation (CA) of AF in the overall cohort of heart failure patients, corresponding data in TEER patients are lacking.

Objectives

To investigate the impact of treatment regimens for concomitant AF on survival of TEER patients.

Methods

In a multicenter observational cohort study consecutive patients successfully undergoing TEER were analyzed and survival of patients receiving CA of concomitant AF was compared with that of patients on pharmacological AF treatment and with that of patients without a history of AF, using propensity score matching (PSM).

Results

A total of 821 patients were analyzed. Of these, 608 (74.1%) had concomitant AF, of whom 48 patients received CA. Patients with CA in AF showed significantly higher 3-year-survival after TEER compared to PSM-patients on pharmacological AF treatment (75.5% [36/48] vs. 49.4% [166/336], p = 0.009). The 3-year-survival after TEER of patients with concomitant AF treated with CA was not significantly different from PSM-patients without AF (75.5% [36/48] vs. 68.3% [98/144], p = 0.36).

Conclusions

CA of AF is superior to pharmacotherapy as it significantly improves the survival of TEER patients in a PSM analysis. CA even offsets the prognostic disadvantage of coexisting AF in TEER patients. Given the growing evidence of prognostic benefits in the overall cohort of HF patients, our data point out the importance of treating concomitant AF and support CA as an essential part of a holistic management of TEER patients.
Multimodality imaging assessment of primary pericardial rhabdomyosarcoma: a case report
Authors: Li Xingxuan , Cao Yukun , Shao Guozhu , Cui Yue , Li Yumin , Zhang Kailu , Liu Xiaoqing , Shi Heshui
Published: August 2023

Primary pericardial sarcomas are rare and lethal diseases. To date, only a few cases of primary pericardial sarcomas, such as rhabdomyosarcoma (RMS), have been reported. Since the unusual location of RMS in the pericardium makes it challenging to diagnose, precise diagnostic procedures are required. In this study, we present the case of a 23-year-old man who experienced postprandial obstruction and atypical precordial pain that lasted for a week. Echocardiography revealed a heterogeneous isoechoic pericardial mass with a significant pericardial effusion. Contrast-enhanced CT revealed a massive pericardial effusion along with an irregular, defined, heterogeneously enhancing mass that was located between the pericardium and diaphragm. PET-CT imaging showed an intense FDG uptake in the pericardial mass. Furthermore, cardiac MRI demonstrated malignant characteristics of the pericardial mass and provided a detailed visualization of its exact anatomical connection with both cardiac and extracardiac structures. Finally, a pathologic examination of a puncture biopsy specimen confirmed the diagnosis of primary pericardial RMS. Our case emphasizes the importance of multimodal imaging for the differential diagnosis and evaluation of cardiac involvement, while providing clinicians with crucial information for clinical treatment and decision-making.
When work bothers your mind: a diary study on the relationship of German teachers’ work-related rumination with fatigue
Authors: Weiher Gerald M. , Varol Yasemin Z. , Horz Holger
Published: August 2023

This study investigated the association of school attendance restrictions in the early stages of the coronavirus disease pandemic with teacher-specific workload, and work-related rumination of teachers in Germany. Deduced from the effort-recovery model, that assumes that work might lead to strain reactions, making recovery necessary to avoid long-term health impairments, fatigue and positive as well as negative contents of work-related rumination in nonwork time were investigated in a five-day diary study with three measurement points per day. A total of 1,697 daily measures of 174 teachers were gathered over three consecutive workdays and the weekend. Only those days were included in which the teachers worked. Multilevel structural equation modeling revealed that teachers during school restrictions showed lower teacher-specific workload, which was associated with lower levels of affective rumination and problem-solving pondering. The effect on fatigue was mediated only by affective rumination such that a higher affective rumination was related to a higher fatigue level on the between and within-level. There was a significant three-path mediation from group belongingness over teacher-specific workload to affective rumination and fatigue. Problem-solving pondering did not affect fatigue level. The present study provides evidence of the association of COVID-19 restrictions with teacher-specific workload and the importance of differentiating the facets of work-related rumination.
Numerical study on density-driven convection of CO2-H2S mixture in fractured and sequential saline aquifers
Authors: Liu Boyu , Yao Jun
Published: August 2023

Dissolution trapping stands as a critical mechanism for the geological carbon storage (GCS) and can be notably improved through density-driven convection. However, to the best of the author’s knowledge, the discussion on density-driven convection of CO2-H2S mixture has been limited to the exclusion of intersected fractures and lithology sequence effects. Therefore, this study aims to systematically investigate the impact of H2S concentration, fractures, and lithology sequence on convective mixing. Four distinct mechanisms that influence convective mixing of CO2-H2S mixtures in the presence of fractures were identified: 1) accelerated downward solute transportation in fractures, 2) coalescence between plumes around fractures and primary down-swelling plumes, 3) high fracture conductivity inhibiting plume migration across fractures, and 4) upward flow in fractures facilitating the transport of high-concentration solute out of the system. Additionally, the effects of lithology sequence on the shape of CO2 plumes and the curve shape of the total flux at the top boundary were described. The results demonstrated that density-driven convection is enhanced with decreasing H2S concentration and increasing fracture interaction angle and fracture conductivity ratio. The magnitudes of density-driven convection, ranked from high to low, are fining downward, uniform, and fining upward lithology sequences. Furthermore, the H2S concentration affects the flow direction within fractures and alters the relative magnitude of the dimensionless concentration in the noise sequences. The findings of this study on a small scale were proven to be applicable on a large scale.