bluuebunny/crossref_metadata_2025 huggingface dataset:
СУЧАСНИЙ СТАН ДОХІДНОСТІ БАНКІВСЬКОГО СЕКТОРУ УКРАЇНИ
Authors: Гнидюк Інна , Маршук Ліна , Тімошенко Наталія
Published: May 2024

Стаття розглядає сучасний стан дохідності банківського сектору України в умовах воєнного часу. Зокрема, досліджується вплив воєнного конфлікту на фінансові показники банків, такі як кредитний ризик, ліквідність, та загальний фінансовий стан. Розглядаються можливі стратегії та заходи, які банки можуть вжити для збереження доходності в умовах війни. Висвітлюються також перспективи розвитку банківського сектору в контексті воєнного конфлікту та можливі шляхи адаптації до непередбачуваних обставин. Дослідження спрямоване на визначення ключових факторів, що впливають на дохідність банківського сектору в умовах війни та розробку рекомендацій для управління фінансовими ризиками. Доведено, що повномасштабне вторгнення значно вплинуло на дохідність банківського сектору України через збільшення кредитного ризику, зменшення ліквідності, зміни в економічному середовищі та зростання потреби у фінансовій підтримці для військових операцій та відновлення інфраструктури. Також, війна призвела до збільшення втрат від неплатоспроможності позичальників та загальної невизначеності на ринку.
ОСОБЛИВОСТІ РОЗВИТКУ ВІДНОВЛЮВАНОЇ ЕНЕРГЕТИКИ В УКРАЇНІ ТА СВІТІ
Authors: Приходько Ірина , Ігнатишин Володимир , Приходько Юрій
Published: May 2024

Стаття присвячена особливостям розвитку відновлюваної енергетики в Україні та світі. Спершу розглянуто тлумачення та наведено класифікаційні ознаки відновлюваних джерел енергетики. Особливу увагу приділено аналізу та особливостям запровадження альтернативних джерел енергії у світі на сучасному етапі. На основі аналізу визначено основні переваги запровадження «зелених» методів генерації енергії. Визначено, що частка відновлюваних джерел енергії в структурі електроенергії є закономірно високою в країнах зі сприятливими кліматичними умовами та великими гідроенергетичними ресурсами. Узагальнено перспективи подальшого запровадження ефективного механізму управління енергозбереження. Наведено основні шляхи переходу України на альтернативну енергетику у період відбудови після повномасштабної російсько-української війни.
Особливості діагностики та лікування бруксизму у осіб молодого віку
Authors: Клітинська Оксана Василівна , Мартиць Юрій Миколайович , Мартиць Остап Юрійович
Published: May 2024

Мета дослідження – вдосконалення алгоритму діагностики та лікування бруксизму у осіб молодого віку. Матеріали і методи. 85 пацієнтам (38 чоловіків – 44,7%, 47 жінок – 55,3%) було проведено анкетування, пальпацію жувальних м'язів, оцінено стан скронево-нижньощелепного суглобу (СНЩС), стоматологічний огляд, оклюдографія, ортопантомографія, електроміографія жувальних м'зів, полісомнографія. Математичний аналіз здійснювався з використанням програмного забезпечення «Statistica 6.0» та «Microsoft Office Excel 2003». Результати та їх обговорення. У всіх групах встановлено наявності шкідливих звичок, зокрема, паління, кусання губ, щік, язика та нігтів. Згідно оклюзійного індекса та показників пальпації жувальних м'язів встановлено, що у пацієнтів досліджуваних клінічних груп вірогідно гірші показники відносно показників пацієнтів контрольної групи (р<0,05); виявлено наявність дискомфорту та больових відчуттів, реєструються вірогідні відмінності показників електроміографії жувальних м'язів від показників норми. Висновки. Алгоритм діагностики та лікування бруксизму базувався на переважанні етіологічного чинника, зокрема, для групи 1 – лікування ортодонтичної патології та усунення супраконтктів, для групи 2 – нормалізація тонусу жувальних м'язів та ліквідація проявів патології скронево-нижньощелепних суглобів, для групи 3 – корекція психоемоційних станів.
Профіль Закарпатської області в розвитку пандемії коронавірусної хвороби COVID-19 в Україні
Authors: Слабкий Геннадій Олексійович , Білак-Лук’янчук Вікторія Йосипівна , Гечко Михайло Михайлович
Published: May 2024

Мета: дослідити профіль Закарпатської області в розвитку пандемії коронавірусної хвороби COVID-19 в Україні. Матеріали та методи. Матеріали: статистичні дані МОЗ України щодо розвитку пандемії коронавірусної хвороби COVID-19 в Україні за 2020-2023 рр. За 2023 рік дані представлені за 6 місяців. Аналіз проводився з урахуванням територій, які подконтрольні Україні. Методи: медико-статистичний, структурно-логічного аналізу. Результати та їх обговорення. В Закарпатській області показник захворюваності населення на COVID-19 в 2020 році був у 1,24 разу нижчим ; в 2021 році був у 1,34 разу нижчим; в 2022 році був у 1,44 разу нижчим, за шість місяців 2023 року вказаний показник був у 1,86 разів нижчим ніж в середньому по Україні. В Закарпатській області показник активних хворих на COVID-19 в 2020 році був у 2,71 разу нижчим; в 2021 році був у 1,96 разу вищим; в 2022 році був у 5,93 разу нижчим ніж в середньому по Україні. За шість місяців 2023 року вказаний показник був у 4,23 разів нижчим ніж в середньому по Україні і поряд із Запорізькою областю був найнижчим серед регіонів України. В Закарпатській області показник смертності населення внаслідок COVID-19 в 2020 році був у 1,04 разу вищим; в 2021 році був у 1,33 разу нижчим; в 2022 році був у 1,29 разу нижчим ніж в середньому по Україні і був найнижчим в Україні. За шість місяців 2023 року вказаний показник був у 1,1 разу нижчим ніж в середньому по Україні, але вищим ніж у 9 (36,0%) регіонах країни. За період пандемії в Україні на COVID-19 захворіло 154637 медичних працівників (Закарпатська область – 5398, 3,5% від загальної кількості) із яких померло 1256, що склало 0,81% від кількості захворілих (Закарпатська область – 34; 0,63% від кількості захворілих в області). Висновки. Результати дослідження профілю Закарпатської області в розвитку пандемії коронавірусної хвороби COVID-19 в Україні дозволили зробити висновок про більш м’який перебіг пандемії на рівні області ніж країни в цілому.
Ключові аспекти використання пробіотичних штамів нового покоління в 3П медицині: виклики та перспективи
Authors: Бурмей Світлана Андріївна , Бойко Надія Володимирівна
Published: May 2024

Сьогодні виробництво фармабіотиків «нового покоління» зіткнулось з новими викликами через спробу розширення використання нових нетипових пробіотичних штамів. В даному огляді висвітлено потенціал використання пробіотичних штамів нового покоління (пробіотиків, метабіотиків, NGPs), як активних компонентів новітніх пробіотичних препаратів з доведеною клінічною дією. Мета дослідження. Дослідити можливість застосування нетипових пробіотичних штамів та оцінити їх потенціал для створення фармабіотиків нового покоління. Матеріали та методи. В основу роботи покладено аналіз та систематизацію власних експериментальних і теоретичних наукових даних. Результати досліджень та їх обговорення. Кишкова мікробіота взаємодіє майже з усіма органами, включно і з центральною нервовою системою, у так званій̆ осі «Кишечник – головний мозок». Мікробіом здорових людей може бути джерелом перспективних пробіотичних штамів мікроорганізмів для створення фармабіотиків з метою профілактики та лікування захворювань різної етіології. При створенні пробіотичних препаратів необхідно звертати увагу на безпеку штамів, здатність коригувати локальну та системну імунну відповідь, антагоністичну активність та наявність окремо визначених адгезивних властивостей. При цьому вони не мають проявляти жодної інгібувальної активності по відношенню до коменсальних мікроорганізмів. Висновки. Для відновлення та корекції мікробіоти шлунково-кишкового тракту застосовують різні тип біопрепаратів (пре-, про-, син-, метабіотиків). З розвитком сучасних технологій з’явилась можливість використання next-generation probiotics, що сталось проривом у виробництві біопрепаратів нового покоління. Проте, їх призначення має свої лімітуючі фактори, одним з яких є недостатня кількість клінічних досліджень ефективності та виявлення можливих побічних ефектів.
МОДЕЛЬ ІНФРАСТРУКТУРНОГО ЗАБЕЗПЕЧЕННЯ ТРАНСФОРМАЦІЇ КОНКУРЕНТНОГО ПОТЕНЦІАЛУ СУБ’ЄКТІВ ТУРИСТИЧНОЇ ІНДУСТРІЇ
Authors: Єрко І.В.
Published: May 2024

Розроблено модель інфраструктурного забезпечення трансформації конкурентного потенціалу суб’єктів туристичної індустрії. Розглянуто підходи до інфраструктурного забезпечення трансформації конкурентного потенціалу суб’єктів туристичної індустрії. Проаналізовано елементи інфраструктурного забезпечення. Виявлено, що в основу інфраструктурного забезпечення трансформації конкурентного потенціалу суб’єктів туристичної індустрії покладено створення туристичних хабів. Розглянуто базове інфраструктурне забезпечення. Досліджено сферу виробництва туристичних послуг/продуктів. Розглянуто сферу туристичного сервісу. Досліджено допоміжне інфраструктурне забезпечення. Доведено, що модель інфраструктурного забезпечення трансформації конкурентного потенціалу суб’єктів туристичної індустрії, пропонує комплексний підхід який охоплює різні рівні та елементи.
Geometric Evaluation of Highways and Railroads on Safety at Crossings (Case Study of JPL 136 and JPL 138 Madiun City)
Authors: Nurhadi Muhamad , Widi Astuti Septiana , Dewi Puspita
Published: May 2024

Railway and road transportation are land transportation that service users widely use because these modes play an important role in community activities, especially people on the island of Java. The train is a mass transportation with many advantages over other transportation, especially as a solution to the congestion problem in the country. Level crossing is a meeting between the railroad and the highway. Level crossings must meet the standard requirements set by the relevant agencies including geometric conditions, free space and wake space, and visibility so that level crossings are comfortable and safe for vehicles to pass through. The purpose of this study is to evaluate the geometric conditions, free space and shape as well as the visibility of level crossings. This study uses field observations and data from DAOP 7 Madiun to compare field conditions with requirements. The research was conducted at level crossings, namely JPL 136 and JPL 138 Kota Madiun.
Analysis of Mode Integration Facilities at Madiun Station
Authors: Nopriyanto Windi , Widi Astuti Septiana , Dewi Puspita
Published: May 2024

One of the problems that occur at Madiun Station is the need for modal integration. Modal integration can be interpreted as a complete integration of the types or forms (transport) used to move people and goods from one place (origin) to another (destination). Some problems related to modal integration at Madiun Station are not optimal pedestrian facilities, no clear drop zone point for public transport passengers, and more information instructions regarding connecting transportation. In this study, data collection methods were used by observing the existing conditions of the modal integration facilities in the Sriwijaya Earth Station area. Furthermore, a survey was conducted on LRT passengers at Madiun Station regarding the characteristics of LRT service users and the public's willingness to access modal integration facilities. This study uses the Modal Interaction Matrix and Trip Segment Analysis Method. The results of this study using the Modal Interaction Matrix analysis show that the modal integration facility in the Madiun Station area has an interaction level of -160 or can be categorized as a bad interaction. By providing a proposal for the location of the modal integration facility, it can be seen that the interaction value of the modal integration facility at the Sriwijaya Earth Station has increased to -80 or has a Good category. Furthermore, through calculations using the Trip Segment Analysis method, the greatest time value is for public transport users when they want to access the station or when they want to leave the station. The value of the time needed to access the station for public transport users is 15.3 minutes. And it takes 14.4 minutes for train service users who get off at Madiun Station and want to continue their journey using public transportation.
Analysis of the Level of Landslide Susceptibility in the Sakuli Latambaga Area, Southeast Sulawesi
Authors: Rasmita Riza , Chaerul Muhammad , Marzuki Ismail , Gusty Sri , Indrayani Poppy , Sinardi Sinardi
Published: May 2024

The vulnerability of landslides that occur in the Sakuli area, Kolaka Regency is related to topographic conditions which are dominated by mountains and hills, for this reason, research is needed as an effort to determine the level of vulnerability and determine disaster mitigation efforts against the danger of landslides. This type of research is quantitative descriptive by looking at the influence of each variable to analyze landslide-prone areas. The method used in this research is experimental analysis with direct observation in the field. From the research results, the vulnerability level value for the slope parameter was 0.83; with soil texture 0.408; for faults 0.86; value for regolith 0.363; with geological conditions 0.628; with a rainfall value of 0.3 and land use of 0.6, the accumulated value is that the research area is at a very vulnerable level with a value of 3.989. Therefore, this area really needs structural and non-structural mitigation to be able to protect and reduce the potential for landslides.
Analysis of Resource Needs in South Banjarmasin District of Banjarmasin City
Authors: Rahmadani Arif , Munawir Abdillah
Published: May 2024

This study aims to project and analyze facility needs in South Banjarmasin Subdistrict, Banjarmasin City. The need for adequate and efficient facilities has a significant impact on people’s daily lives and also has the potential to affect the economic growth and development of this area. Therefore, a comprehensive analysis is needed to identify the main needs that should be accommodated by public facilities and infrastructure. The research method used is a quantitative research method with an in-depth and comprehensive approach. The analysis used is to conduct a projection and analysis of facility needs. The hope is that this research will provide options for the Banjarmasin City government on facilities that need to be added to support community activities in South Banjarmasin Sub-district. The results show that there is a shortage of facilities for education, worship (especially mosques), health (such as posyandu and community treatment centers), and green open spaces (including playgrounds and cemeteries). These findings can serve as a basis for the government of Banjarmasin City in making policies and allocating appropriate resources to meet the needs of the facilities required by the community in South Banjarmasin Subdistrict.
Newman's Error Analysis: The Students' Errors in Solving Word Problems of Proportion
Authors: Indriana Indriana , Pathuddin Pathuddin , Lefrida Rita , Alfisyahra Alfisyahra
Published: May 2024

Students' errors in solving mathematical problems need to be analyzed in depth so that teachers can choose the right way to anticipate the repetition of the same errors. This study aims to reveal the types of errors made by students in solving word problems on the topic of proportion. This study is a descriptive study with a qualitative approach. The subjects involved were two seventh grade students, male and female. The results of this study indicate that based on Newman's error analysis, male subjects mainly made errors in understanding the problem, transformation errors, and writing the final answer that did not include a conclusion. While female subjects made errors in understanding the problem, choosing the operation used, and writing the conclusion sentence in the final answers. The results of this study can help students understand the errors made so that the errors are not repeated and can be input for teachers in improving the learning process.
Species- and community-level demographic responses of saplings to drought during tropical secondary succession
Authors: Lai Hao Ran , Cheeseman Alexander , Hall Jefferson , Slot Martijn , van Breugel Michiel
Published: May 2024

Naturally regenerating secondary vegetation dominates the tropical forest landscapes, showing a remarkable capacity to sequester carbon, but such a role is threatened by increasing drought predicted with climate change. To understand how secondary forest species and communities respond to drought, we leverage a long-term chronosequence of tropical successional forests from Central Panama that coincided with the 2015/16 El Niño extreme drought event to analyse the diameter growth and mortality of 113,505 saplings and 60 species under water stress. As expected, drought negatively impacted most species in either diameter growth, mortality, or both. However, we additionally found that neighbourhood basal area ameliorated or exacerbated the effect of drought on diameter growth of some species. These species-level demographic responses aggregated to a community-level shift from the dominance of drought-susceptible saplings to more drought-tolerant saplings during stand development. Our study highlights that sapling communities in older secondary forests were less sensitive to drought: they suffered less growth reduction possibly due to denser canopies that mitigated evapotranspiration, and they also experienced lower mortality due to a higher relative abundance of drought-resistant species. Saplings in young secondary forests were overall more susceptible to drought, but their responses were also highly variable, suggesting a potential in understanding why some young secondary forest communities are more drought-tolerant, a knowledge that can be leveraged to restore resilient forests necessary to withstand a future of increased drought frequency and severity under a changing climate.
Current Status of Marco Polo Sheep (Ovis ammon polii) in the Pamir Mountains of Badakhshan Province, Afghanistan
Authors: Junaidullah Sabooryar  , Amirullah Arifi  , Majidi Abdul Hallim , Ghulam Rabani Neyazi
Published: May 2024

The present survey was conducted to determine the abundance and population density of Marco Polo sheep in the Pamir Mountains of Badakhshan Province, Afghanistan. Marco Polo sheep inhabitants in very high mountain regions experience extremely cold winds and arid climatic conditions throughout the year. The Marco Polo sheep is listed as a critically endangered species on the IUCN Red List. Field surveys and interviews were carried out from 2022 to 2023 by using semi-structured questionnaires. 98 respondents were interviewed, and line transect walks in the field were used to observe the Marco Polo Sheep in the study region. As a result, a total of 1304 Marco Polo Sheep individual were recorded in the Pamir regions. The highest number of Marco Polo Sheep observations is related to the Tollaboy region, with 452 individuals (34.6%), and the lowest number of observations is in the Angelic region, 93(7.1%). According to the study area's locality, the population density of the Marco Polo Sheep differs in each season of the year. In conclusion, the highest density was in the Tollaboy region with 125.5± 3.5 per km2, and the lowest density was in the Angelic region10.7±1.6 per km2 ware observed.
Evaluation of the achievements of community health center work program indicators in the family health aspect
Authors: Budiman Budiman , Menap Menap , Karjono Karjono
Published: May 2024

Background: Community health center have a strategic role in providing primary services, including family health services and monitoring. Family health is the main foundation for the welfare of society as a whole. Through good service at the family level, various health problems can be identified and treated early, preventing the potential
Purpose: To measure and evaluate the success of community health centers in providing family health services.
Method: Descriptive research with the main data source coming from community health center performance evaluation documents. Data collection was carried out at the Wanasaba Community Health Center, East Lombok Regency. The data used in this research were obtained from various public health center performance evaluation documents, such as activity reports, health service records, and other related documents. Data analysis in this research will be carried out using a descriptive approach, where data obtained from performance evaluation documents will be described and interpreted in depth.
Results: This evaluation shows that several aspects have gone well, but there are also aspects that require further attention. Health promotion, it can be seen that the dissemination of health information through electronic media reached a good achievement level of 98.30%. In terms of environmental health, it reaches a good level. In improving community nutrition, the results showed good success in efforts to prevent and control disease, successfully implementing various disease control activities (96.69%). In terms of public health services, it achieved a good achievement level of 92.2%. When turning to family health, there are several areas that require further attention because the percentage is smaller than other areas. Overall, the family health aspect is included in the poor category (74.74%).
Conclusion: There are good achievements in several aspects, but there are still several shortcomings and potential improvements. Overall, community health centers have taken positive steps in improving work programs, one of which is family health, especially in maternal health and family planning. However, continuous efforts are needed to improve achievements in certain aspects, such as the health of children under five, the health of school-aged children, the health of adolescents and the health of the elderly.
Suggestion: For future researchers, it is important to deepen their understanding of the local context and involve active community participation in the design and implementation of research.
Predictionof Protective Capacity of the Nubian Aquifer Using Electrical Resistivity Method in Bahri City, Sudan
Authors: Mohammed Musaab Adam Abbakar , Szabó Norbert Péter , Szűcs Péter
Published: May 2024

This research employed electrical resistivity method to determine the protective capacity of groundwater aquifers in Bahri city. The protective capacity predicts the vulnerability of aquifers to surface and subsurface contamination. In this study, vertical electrical sounding (VES) technique using Schlumberger array was conducted to determine the thicknesses of the subsurface layers. The VES measurements and borehole lithological logs were jointly interpreted to decrease the uncertainty of the resulting models. Consequently, five geoelectrical layers including two aquifers were indicated. The product of VES models including true resistivity and thickness used to measure the Dar Zarrouk parameters. The total longitudinal conductance and transverse resistance were used to detect the protective strength and thus the vulnerability of groundwater aquifers. In general, the protective capacity of the overburdened sediments ranged from good to very good. Accordingly, the aquifer in the study region is indicated as naturally protected and ideal for groundwater extraction. However, a comprehensive groundwater quality investigation is recommended for the safe use of groundwater for human consumption.
Examination of Topographical Parameters in Vineyard Areas : Changes in the Szekszárd Wine Region
Authors: Kalmár Enikő Mária , Pecsmány Péter
Published: May 2024

The Szekszárd Wine Region holds prominent significance among the Hungarian wine regions, as written sources confirm that the Romans already cultivated grapes in the area as early as the 3rd century AD. The eastern part of the Szekszárd hills provides favorable topographical, soil, and climatic conditions, enabling the cultivation of characteristic grape varieties. In our research, we examined the changes in vineyard areas within the wine region. We also investigated whether there have been any changes in the preferred topographical characteristics (aspect, slope steepness) during different time periods in the context of vineyard cultivation.
Management of Agricultural Groundwater in Sudan: The Use of Artificial Intelligence Algorithms in Khartoum State
Authors: Mohammed Musaab A. A. , Abba Sani I. , Szabó Norbert Péter , Szűcs Péter
Published: May 2024

This research aims to predict the irrigation indices of sodium adsorption ratio (SAR) and sodium percentage (Na%) using innovative machine learning (ML) techniques, including support vector regression (SVR) and Gaussian process regression (GPR). Thirty-seven groundwater samples were collected, and the primary investigation indicated that Ca-Mg-HCO3 and Na-HCO3 water types dominate the samples. The data is divided into two sets for training (70%) and validation (30%), and the models are tested with three statistical criteria, including mean square error (MSE), root mean square error (RMSE), and determination coefficient (R2). The GPR algorithm showed better performance in predicting SAR and Na% than SVR since it provided the lowest errors. The implemented approach proved efficient for the sustainable management of agricultural water.
Especie pura del aire
Authors: Ortiz-Moyano Carlos Luis
Published: May 2024

En Carlos Luis Ortiz la poesía vuelve a tener el refrescante sabor de la pasión vital, del vicio mortal. Especie pura del aire condensa y decanta –en clave de química– sus tribulaciones personales y su irrefutable vocación poética: “Repasar la vida como si fuera a limpiar la madera con cera, / con aceite de mueble, / sentirla, al pasar la mano sobre el paño de una mesa de billar /en un cuarto oscuro, / en un cuarto claro, / para no palpar tan cercano este apocalipsis, /esta sinrazón…”, dice el poeta y cumple su promesa hasta el “FIN” (rúbrica cinematográfica y lapidaria con la que cierra este poemario) sin que su pulso escritural y su impulso emocional desmayen jamás. A veces hay en este libro un tono, un sonido, un adjetivo que recuerdan algunos momentos de César Dávila Andrade. No es solo el eco de las lecturas, se trata de una suerte de afinidad íntima, vinculada a un profundo sentimiento de desarraigo. Si el gran poeta cuencano se perdió en el espacio, Ortiz parece extraviado en “la entera desnudez del tiempo”. No es descabellado decir que alma del Fakir –que a comienzos de los años cincuenta trajinó sin hallarse por las calles de Guayaquil–, ha encontrado en la errancia existencial de Carlos Luis Ortiz una continuidad secreta. Escindidos, fracturados, fatalmente heridos, ambos saben hablar de un modo otro con la madre y con los muertos, ambos comparten –visceralmente– los “campamentos de cercana tristeza”. 62 páginas ISBN: 978-9942-645-69-2 e-ISBN: 978-9942-645-70-8
Eğitimcilerin mesleki gelişimine yönelik çevrimiçi öğrenme araştırmalarının sistematik analizi
Authors: Özdemir Ezgi , Dağ Funda
Published: May 2024

Eğitimin niteliğinin artmasında atılacak adımlardan biri eğitimcilerin mesleki gelişimlerinin sağlanmasıdır. Türkiye’de sadece öğretmenlerin sayısının bir milyonu geçtiği düşünüldüğünde mesleki gelişim eğitimlerinin yüz yüze yapılmasının zorluğu göze çarpmaktadır. Bu noktada, avantajlı yönleriyle çevrimiçi öğrenme ortamları çözüm olarak karşımıza çıkmaktadır. Bu araştırma, Türkiye’de eğitimcilerin mesleki gelişimine yönelik çevrimiçi öğrenme araştırmalarının incelenmesi amacıyla, sistematik alanyazın taraması yöntemiyle, oluşturulan betimsel bir araştırmadır. Yöktez ve TR Dizin veri tabanlarında, belirlenen anahtar kelimelerle yapılan tarama seçim ve dışlama kriterleri çerçevesinde değerlendirildikten sonra 29 araştırma analiz sürecine alınarak incelenmiştir. Araştırmalar; öncelikle betimsel özellikleri açısından analiz edilmiştir. Ayrıca; konu ve alan, kullanılan model/kuramsal ve kavramsal yaklaşımlar, olumlu/olumsuz yönler, beklentiler ve öneriler olarak temalara göre incelenmiştir. Araştırmaların yıllara göre farklılaştığı, örneklem olarak çoğunlukla öğretmenlerin tercih edildiği, nitel araştırma yöntemlerinin daha fazla kullanıldığı, veri toplama aracı olarak çoğunlukla görüşmenin tercih edildiği gözlenmiştir. Amaçlarına göre incelendiğinde keşfedici ve betimleyici araştırmaların daha fazla yapıldığı, konuları açısından ise daha fazla mesleki gelişime ilişkin bir durumun incelendiği araştırmaların yapıldığı görülmüştür. Araştırmaların yarısından fazlasında mesleki gelişim açısından bir kuramsal veya kavramsal çerçeveye yer verilmediği, bu yönde bilgi sunan az sayıda araştırmada ise harmanlanmış öğrenme yaklaşımı ve hayat boyu öğrenme kuramına yer verildiği görülmüştür. İncelenen çevrimiçi mesleki gelişim araştırmalarında olumlu yönlerin esneklik, verimlilik ve ekonomiklik; olumsuz yönlerin ise teknik destek ve teknolojik altyapı yetersizliği olarak vurgulandığı belirlenmiştir. Araştırmalarda eğitimlerin uygulamalı, ulaşılabilir olması beklentiler içinde yansıtılmış; araştırmacılara çevrimiçi ortamlarda öğretmenler arası etkileşimi inceleyen araştırmaların yapılmasının önerildiği belirlenmiştir.
Organ-specific Toxocara canis larvae migration and host immune response in experimentally infected mice
Authors: Kim Min Seok , Jin Yan , Woo Se Joon
Published: May 2024

We investigated organ specific Toxocara canis larval migration in mice infected with T. canis larvae. We observed the worm burden and systemic immune responses. Three groups of BALB/c mice (n=5 each) were orally administered 1,000 T. canis 2nd stage larvae to induce larva migrans. Mice were sacrificed at 1, 3, and 5 weeks post-infection. Liver, lung, brain, and eye tissues were collected. Tissue from 2 mice per group was digested for larval count, while the remaining 3 mice underwent histological analysis. Blood hematology and serology were evaluated and compared to that in a control uninfected group (n=5) to assess the immune response. Cytokine levels in bronchoalveolar lavage (BAL) fluid were also analyzed. We found that, 1 week post-infection, the mean parasite load in the liver (72±7.1), brain (31±4.2), lungs (20±5.7), and eyes (2±0) peaked and stayed constant until the 3 weeks. By 5-week post-infection, the worm burden in the liver and lungs significantly decreased to 10±4.2 and 9±5.7, respectively, while they remained relatively stable in the brain and eyes (18±4.2 and 1±0, respectively). Interestingly, ocular larvae resided in all retinal layers, without notable inflammation in outer retina. Mice infected with T. canis exhibited elevated levels of neutrophils, monocytes, eosinophils, and immunoglobulin E. At 5 weeks post-infection, interleukin (IL)-5 and IL-13 levels were elevated in BAL fluid. Whereas IL-4, IL-10, IL-17, and interferon-γ levels in BAL fluid were similar to that in controls. Our findings demonstrate that a small portion of T. canis larvae migrate to the eyes and brain within the first week of infection. Minimal tissue inflammation was observed, probably due to increase of anti-inflammatory cytokines. This study contributes to our understanding of the histological and immunological responses to T. canis infection in mice, which may have implications to further understand human toxocariasis.
Impact of letrozole on prevention of early-onset ovarian hyperstimulation syndrome in GnRH antagonist protocol: A Randomized Controlled Trial
Authors: Hakim Ahmed Abdel , Al Saidi Fatma Gamal , Gomaa Ihab , Elkholy Abdel Latif , Abbas Ahmed
Published: May 2024

Background: Letrozole is an aromatase inhibitor that decreases the risk of Ovarian Hyperstimulation Syndrome (OHSS) in assisted reproductive technology. We aimed to evaluate the clinical outcomes of high-risk patients undergoing different Intracytoplasmic Sperm Injection (ICSI) protocols, one with letrozole and one without. Patients and Methods: This RCT was done at the assisted reproduction unit, Ain Shams University Maternity Hospital, from February 2022 to May 2023. A total of 170 infertile women with polycystic ovarian syndrome were enrolled and divided into two equal groups; the study group consisted of 85 women who received controlled ovarian stimulation with a conventional antagonist protocol and letrozole, and the control group consisted of 85 women who received controlled ovarian stimulation with a conventional GnRH antagonist protocol and a placebo. Results: Letrozole could not decrease the incidence of total early-onset ovarian hyperstimulation syndrome compared with placebo treatment. Conversely, letrozole significantly reduced the severity and grades of early-onset OHSS in the study group. Letrozole significantly lowered the number of retrieved oocytes, which, according to our study results, was the only independent risk factor for OHSS. Letrozole also decreased estrogen on the day of the trigger injection. Also, letrozole did not affect biochemical/clinical pregnancy rates, total gonadotropin dose needed for induction of ovulation, endometrial thickness on the day of trigger, or embryos transferred per cycle. Conclusion: In high-risk, PCO infertile women undergoing ICSI, letrozole had no role in the prevention of the development of early-onset ovarian hyperstimulation syndrome. But it decreases its severity if occurred.
Characterization of Erwinia amylovora causing Twig Blight of Loquat Tree in Loquat Growing Areas of Punjab and KPK, Pakistan
Authors: Mumtaz Alveen , Naz Farah , Irshad Gulshan , Hayat Riffat
Published: May 2024

Twig blight of loquat (Eriobotrya japonica Lindl.), caused by the gram-negative enterobacterium Erwinia amylovora, is a major constraint to loquat production worldwide. Recent surveys in loquat-growing areas of Punjab and KPK, Pakistan—specifically in Chakwal (Kalar Kahar, Choa Saidan Shah), Rawalpindi (Taxila, Wah), Murree (Tret and Chattar), and Haripur (Haripur, Khanpur, and Sara i Saleh)—revealed that this disease is highly prevalent. Twig blight compromises the health and vigor of loquat trees, often leading to their death, which discourages farmers from cultivating loquat commercially. Consequently, the area under loquat cultivation and its production have both been declining. Despite the severity of the issue, no systematic studies had been conducted to address this problem until now. A survey was carried out over two consecutive years (2016 and 2017) in 10 loquat-growing locations in Punjab and KPK (three orchards per location). The incidence of twig blight was higher in 2017 compared to 2016. The highest incidence was recorded in Taxila, with 69.74% in 2016 and 78.39% in 2017, while the lowest was in Kalar Kahar (20.86%). The incidence in Kalar Kahar showed a slight increase of less than 1% from the previous year, likely due to effective control measures implemented to limit the spread of the disease. The pathogen E. amylovora was isolated from diseased samples. Out of 102 bacterial isolates, 92 strains were gram-negative, and 72 tested positive in various biochemical assays (Levan, lipase, KOVAC oxidase, glucose fermentation, catalase oxidase, growth at 39°C, production of fluorescent pigment, and pectolytic activity tests). Three highly virulent isolates were identified through pathogenicity tests and confirmed by biochemical and molecular indicators. Molecular tagging of two chromosomal genes (amsB [MN902191] and Pst-glms [MN915084]) and one plasmid gene (pAE29 [MN902192]) was performed, confirming the identity of the isolates as E. amylovora. This study represents the first report of E. amylovora infecting loquat in Pakistan.
Response of Tomato Plant to Abiotic (Heat Stress) and Biotic (Tomato Leaf Curl New Delhi Virus, TOLCNDV) Factors
Authors: Ali Muhammad A. , Khan Muhammad A. U. , Rao Abdul Q.
Published: May 2024

Tomato (Lycopersicon esculentum) is a vital fruit-bearing plant renowned for its nutritional advantages. Subjected to various environmental stresses, its yield is significantly impacted. Plants, confronting combined biotic and abiotic stresses, exhibit diverse responses through the evolution of cellular defense mechanisms. Sensitivity to extreme temperatures and pathogenic threats, such as the white fly-transmitted tomato leaf curl New Delhi virus (ToLCNDV), a Begomovirus, underscores the global susceptibility of tomato crops. This study aimed to assess tomato plant responses to the compounding stress of heat and agroinfiltrated ToLCNDV, analyzing four key physiological parameters viz., photosynthesis rate, stomatal conductance, transpiration rates, and Water use efficiency. Results indicated reduced photosynthesis rate of 5.1 ± 0.54 % mol CO2 m-2s-1, diminished stomatal conductance of 89.84±1.27% mmol.m-2s-1, and transpiration rates of 0.978 ± 0.148 %mmol.m-2s-1 as compared to control group as 8.56 ± 0.55 % mol CO2 m-2s-1, 189.08±19.13%mmol.m-2s-1and 2.586 ± 0.415 % mmol.m-2s-1respectively. Water use efficiency increased in double-stressed plants at 9.1 ± 0.96 % mmol CO2mol-1 H2O with respect to control 5.84 ± 0.48 % mmol CO2mol-1 H2O. The combined stressors manifested a net adverse impact, with neither ToLCNDV mitigating heat stress effects nor vice versa. Contrarily, their combined consequences were significantly amplified compared to individual stressors, emphasizing the intricate interplay of heat stress and ToLCNDV on tomato plants. This research marks a pioneering effort to uncover the physiological responses of a vulnerable tomato cultivar to the combined pressures of ToLCNDV and heat stress. Furthermore, it signifies a novel pathway towards the development of transgenic cultivars capable of effectively managing these stresses.
Implementasi Basis Pengetahuan Menggunakan Metode Teorema Bayes (Studi Kasus: Diagnosis Gangguan Perilaku pada Anak)
Authors: Andriani Feny , Sastypratiwi Helen , Tursina Tursina
Published: May 2024

Gangguan perilaku merupakan suatu kondisi dimana seseorang mengalami gangguan berupa perubahan dalam hal tingkah laku maupun emosi, yang cenderung dialami oleh usia anak-anak. Pada dasarnya, untuk mengetahui permasalahan perilaku yang dimiliki anak, orang tua dapat melakukannya dengan bantuan seorang pakar atau ahli yang sering disebut sebagai psikolog. Oleh sebab itu, dengan perkembangan teknologi yang begitu pesat, dilakukan penelitian ini dengan tujuan untuk menghasilkan sebuah sistem yang mampu melakukan diagnosis terhadap gangguan perilaku pada anak. Selain itu, penelitian ini juga bertujuan untuk memeroleh perbandingan hasil diagnosis apabila tidak digunakan nilai preferensi pakar dan apabila menggunakan nilai preferensi pakar dalam melakukan diagnosis. Sistem dibuat dengan mengimplementasikan basis pengetahuan dan dengan menggunakan metode teorema bayes sebagai teknik penelusuran dalam menemukan hasil diagnosis gangguan perilaku berdasarkan gejala yang dialami oleh anak. Pada penelitian ini, digunakan 5 jenis gangguan perilaku dan 20 gejala, serta 5 pengetahuan yang terdapat pada basis pengetahuan. Pengujian sistem dilakukan dengan menggunakan metode pengujian black box dan pengujian validitas. Hasil pengujian menunjukkan bahwa sistem yang dibangun dapat berjalan dengan lancar tanpa adanya error. Sehingga dapat disimpulkan bahwa sistem diagnosis gangguan perilaku pada anak dengan mengimplementasikan basis pengetahuan dan menggunakan metode teorema bayes berhasil dibangun dalam penelitian ini. Selain itu, juga dapat disimpulkan bahwa proses diagnosis yang dilakukan tanpa menggunakan nilai preferensi pakar dan dengan menggunakan nilai preferensi pakar dapat digunakan dalam mendiagnosis gangguan perilaku pada anak. Hal tersebut dikarenakan kedua proses diagnosis memeroleh hasil berupa gangguan perilaku yang sama.
Algorima K-Means dalam Clustering Produk Skincare untuk Menentukan Strategi Pemasaran
Authors: Barata Mula , Ayuni Intan Sri , Kartini Alif Yuanita , Alawi Zakki
Published: May 2024

Penelitian ini fokus pada pengembangan strategi pemasaran dalam industri kosmetik yang semakin kompetitif. Menggunakan pendekatan data mining dengan algoritma K-Means, penelitian ini bertujuan untuk mengidentifikasi produk-produk terlaris, sedang, dan rendah dalam penjualan. Metode ini memungkinkan pengelompokan produk berdasarkan pola penjualan, memfasilitasi pengambilan keputusan yang efektif dalam meningkatkan laba perusahaan. Dengan menganalisis data penjualan dan mengklasifikasikan produk ke dalam kluster yang sesuai, strategi pemasaran yang lebih cermat dapat dirancang. Hasil yang didapatkan dari perhitungan cluster dari 693 data penjualan skincare yaitu: 392 data termasuk penjualan rendah dan tergolong cluster 1, 13 data termasuk penjualan sedang dan tergolong cluster 2,288 data termasuk penjualan terlaris dan tergolong cluster 3. Hasil penelitian ini dapat memberikan wawasan berharga bagi perusahaan kosmetik dalam mengoptimalkan strategi pemasaran guna mencapai target penjualan dan mengurangi penumpukan stok. Dengan menerapkan Algoritma K-Means pada data penjualan produk kosmetik, perusahaan dapat mengidentifikasi produk yang memiliki kinerja penjualan tinggi, sedang, dan rendah. Langkah ini memungkinkan pengelompokan produk berdasarkan pola penjualan, memudahkan penentuan strategi pemasaran yang sesuai. Berdasarkan hasil cluster yang didapatkan maka ditentukan strategi pemasaran untuk tindak lanjut semua produk mulai dari produk terlaris, fokus pemasaran dapat diperkuat untuk mempertahankan dan meningkatkan penjualan. Untuk produk penjualan sedang, strategi dapat diarahkan untuk meningkatkan popularitas dan meningkatkan penjualan. Sedangkan untuk produk penjualan rendah, perlu dilakukan analisis lebih lanjut untuk mengidentifikasi penyebab rendahnya penjualan dan mengambil tindakan korektif, seperti penyempurnaan produk atau strategi pemasaran yang lebih efektif.
TLR3 signaling-induced interferon-stimulated gene 56 plays a role in the pathogenesis of rheumatoid arthritis
Authors: Ishibashi Hikaru Kristi , Nakamura Yuzuru , Saruga Tatsuro , Imaizumi Tadaatsu , Kurose Akira , Kawaguchi Shogo , Seya Kazuhiko , Sasaki Eiji , Ishibashi Yasuyuki
Published: May 2024

Rheumatoid fibroblast-like synoviocytes (RFLS) have an important role in the inflammatory pathogenesis of rheumatoid arthritis (RA). Toll-like receptor 3 (TLR3) is upregulated in RFLS; its activation leads to the production of interferon-β (IFN-β), a type I IFN. IFN-stimulated gene 56 (ISG56) is induced by IFN and is involved in innate immune responses; however, its role in RA remains unknown. Therefore, the purpose of this study was to investigate the role of TLR3-induced ISG56 in human RFLS. RFLS were treated with polyinosinic-polycytidylic acid (poly I:C), which served as a TLR3 ligand. ISG56, melanoma differentiation-associated gene 5 (MDA5), and C-X-C motif chemokine ligand 10 (CXCL10) expression were measured using quantitative reverse transcription-polymerase chain reaction, western blotting, and enzyme-linked immunosorbent assay. Using immunohistochemistry, we found that ISG56 was expressed in synovial tissues of patients with RA and osteoarthritis. Under poly I:C treatment, ISG56 was upregulated in RFLS. In addition, we found that the type I IFN-neutralizing antibody mixture suppressed ISG56 expression. ISG56 knockdown decreased CXCL10 expression and MDA5 knockdown decreased ISG56 expression. In addition, we found that ISG56 was strongly expressed in the synovial cells of patients with RA. TLR3 signaling induced ISG56 expression in RFLS and type I IFN was involved in ISG56 expression. ISG56 was also found to be associated with CXCL10 expression, suggesting that ISG56 may be involved in TLR3/type I IFN/CXCL10 axis, and play a role in RA synovial inflammation.
Algebraic and toroidal representation of the genetic code
Authors: Rodríguez-Gutiérrez Rodrigo , Hernandez-Cabrera Francisco , Almaguer-Martínez Francisco Javier , Bernal-Alvarado José De Jesús
Published: May 2024

The genetic code is a set of regulatory principles that control the translation of information encoded in messenger RNA (mRNA) into a sequence of amino acids. This study proposes a model starting from the relationships between its physicochemical properties of nucleobase in the codons. We employed a binary metric and the Kronecker product to represent the physicochemical properties of nucleobases in a vector space. This state space has a hierarchical order, with self-similarity and symmetry properties in the hydrogen bonds of triplets. The state space can be mapped under linear transformations to a toroidal geometry with allometric properties. Furthermore, this geometric representation highlights a charge symmetry that exists in amino acids and in the distribution of essential and non-essential amino acids. These results describe a state space between codon-anticodon interactions that can be interpreted as Bell states. This suggests that there is a quantum phenomenon involved in the mechanisms of information storage in DNA. In addition, toroidal geometry can be used to represent the sequences of codons of the mRNA that encode the sequence of amino acids of the proteins to find similarities or homologies between evolutionary related species.
Nanotechnology for the theranostic opportunity of breast cancer lung metastasis: recent advancements and future challenges
Authors: Miao Lin , Kang Yue , Zhang Xin Feng
Published: May 2024

Lung metastasis of breast cancer is rapidly becoming a thorny problem in the treatment of patients with breast cancer and an obstacle to long-term survival. The main challenges of treatment are the absence of therapeutic targets and drug resistance, which promotes the development of nanotechnology in the diagnosis and treatment process. Taking advantage of the controllability and targeting of nanotechnology, drug-targeted delivery, controlled sustained release, multi-drug combination, improved drug efficacy, and reduced side effects can be realized in the process of the diagnosis and treatment of metastatic breast cancer (MBC). Several nanotechnology-based theranostic strategies have been investigated in breast cancer lung metastases (BCLM): targeted drug delivery, imaging analysis, immunotherapy, gene therapy, and multi-modality combined therapy, and some clinical applications are in the research phase. In this review, we present current nanotechnology-based diagnosis and treatment approaches for patients of incurable breast cancer with lung metastases, and we hope to be able to summarize more effective and promising nano-drug diagnosis and treatment systems that aim to improve the survival of patients with advanced MBC. We describe nanoplatform-based experimental studies and clinical trials targeting the tumor and the tumor microenvironment (TME) for BCLM to obtain more targeted treatment and in the future treatment steps for patients to provide a pioneering strategy.
Inverse prediction of PuO2 processing conditions using Bayesian seemingly unrelated regression with functional data
Authors: McCombs Audrey Lamson , Stricklin Madeline Anne , Goode Katherine , Huerta J. Gabriel , Shuler Kurtis , Tucker J. Derek , Zhang Adah , Sweet Lucas , Ries Daniel
Published: May 2024

Over the past decade, a variety of innovative methodologies have been developed to better characterize the relationships between processing conditions and the physical, morphological, and chemical features of special nuclear material (SNM). Different processing conditions generate SNM products with different features, which are known as “signatures” because they are indicative of the processing conditions used to produce the material. These signatures can potentially allow a forensic analyst to determine which processes were used to produce the SNM and make inferences about where the material originated. This article investigates a statistical technique for relating processing conditions to the morphological features of PuO2 particles. We develop a Bayesian implementation of seemingly unrelated regression (SUR) to inverse-predict unknown PuO2 processing conditions from known PuO2 features. Model results from simulated data demonstrate the usefulness of the technique. Applied to empirical data from a bench-scale experiment specifically designed with inverse prediction in mind, our model successfully predicts nitric acid concentration, while results for Pu concentration and precipitation temperature were equivalent to a simple mean model. Our technique compliments other recent methodologies developed for forensic analysis of nuclear material and can be generalized across the field of chemometrics for application to other materials.