bluuebunny/crossref_metadata_2025 huggingface dataset:
Polarization of the feminist movement in Mexico based on digital methods, the sentiment analysis and the hashtags #UNAMFeminista and #UNAMSinTransfobia
Authors:   Universidad de Guanajuato, García González Lidia Ángeles , Iturralde Chaparro Enrique ,   Universidad Nacional Autónoma de México, Ramos Yebra Josué Alejandro ,   Universidad de Guanajuato
Published: September 2023

The main objective of this quantitative research is to is synthesized in knowing from a communication and digital culture perspective the dynamics derived from the polarization of the feminist movement in Mexico, based on the analysis of comments on YouTube and Facebook, as well as the hashtags #UNAMFeminista and #UNAMSinTransfobia on Twitter. Our object of study is the online participation of the audiences of the last forum held on March 24, 2022, entitled: "Necessary clarifications on the Sex and Gender categories", organized by the Center for Interdisciplinary Research in Sciences and Humanities of the UNAM. The use of a repertoire of digital methodologies for the investigation of content generated on Internet platforms is proposed, based on data mining, network analysis, as well as the analysis of sentiments from comments on digital social networks. The objective is to account for the main actors in the digital public sphere that influence affective polarization and the risks of communicative phenomena such as hate speech and discrimination. This research seeks to contribute to feminist movements from communication and digital culture in Mexico, given the scarce academic literature.
Connections between "Extreme Marine Events" and Biological EOVs Report
Authors: Pereiro Diego
Published: September 2023

Identification of local and regional impacts of oxygen, heat and pH related “Extreme Marine Events”: Ocean model data products are overlaid with existing marine biological datasets to identify sensitive areas and organism vulnerabilities.
Beyond gamification: reconceptualizing game-based learning in early childhood environments
Authors: Nolan Jason , McBride Melanie
Published: September 2023

The recent promotion and adoption of digital game-based learning (DGBL) in K-12 education presents compelling opportunities as well as challenges for early childhood educators who seek to critically, equitably and holistically support the learning and play of today's so-called digital natives. However, with most DGBL initiatives focused on the increasingly standardized ‘accountability’ models found in K-12 educational institutions, the authors ask whose priorities, identities and notions of play this model reinforces or neglects. Drawing on the literatures of early childhood studies, game-based learning, and game studies, they seek to illuminate the informal contexts of play within the ‘hidden’ and ‘null’ curricula of DGBL that do not fit within the efficiency models of mainstream education in North America. In the absence of a common critical or theoretical foundation for DGBL, they propose a conceptual framework that challenges what they regard to be the institutionally nullified dimensions of autonomy, play, affinity and space that are essential to DGBL. They contend that these dimensions are ideally situated within the inclusive and play-based curriculum early childhood learning environments, and that the early years constitute a critically significant, yet overlooked, location for more holistic and inclusive thinking on DGBL.
Transformable Personal Space Within a Communal Setting: Housing for the Homeless
Authors: Klassen Filiz
Published: September 2023

The growing homeless population of Toronto is a complex problem that needs to be addressed in new ways. The escalating crisis of homelessness coupled with a shortage of funding for social programs has forced nonprofit organizations to look for alternatives to the under-housed groups. Many attempts have been made at addressing the special issues of ‘sheltering’ a number of vulnerable groups such as the homeless, battered women, psychiatric patients, as well as the physically disabled. Strachan House is one Innovative prototype of communal living that provides long and short-term shelter for seventy chronically homeless men and women in a renovated three-story 19th century warehouse in Toronto. Residents of Strachan House have formed a small community that is largely self-governing, reflecting this project's vision of the homeless as people we can organize, design and build with, rather than people we organize and design for. 
Malleable Matter: Adaptable and Responsive Space
Authors: Klassen Filiz
Published: September 2023

This paper will unravel the effects of the variations in atmospheric conditions on the building envelope as a 'creative potential' for architectural intervention through a research/creation project entitled 'Malleable Matter'. Undertaken as part of a larger investigation of material innovations in architecture, the Malleable Matter project explores the potential of textile-based materials as a hybrid art and architectural medium that can bring design, technology and materials' research together in built spaces.
Designing open access, educational resources / Développer des ressources éducatives en libre accès
Authors: Lapum Jennifer L. , St-Amant Oona , Verkuyl Margaret , Garcia Wendy , Tan Andy , Freeman Wendy , Savicevic Nada
Published: September 2023

The recent bourgeoning of open educational resources has meant greater access to materials with open licenses in the public domain than ever before. Open educational resources are learning tools, such as textbooks, that are freely available and typically accessed online. Despite the expansion of open educational resources, many educators are still unacquainted with the nature and process of producing such resources. The purpose of this discussion paper is to share our experience in developing an open educational e-textbook for students in post-secondary programs for nursing and other health professions while highlighting practical tips for educators. The exemplar referenced in this paper focuses on vital signs’ measurement, a familiar concept for nurse educators, and a topic ubiquitous in healthcare. This paper is suited for any user curious about designing open educational resources with consideration of key elements to produce quality and educational resources that support excellence in nursing pedagogy. We begin by providing a background to our specific project followed by a discussion of the planning phase, the design phase, and other considerations. The e-textbook falls under a Creative Commons license and can be accessed for free by educators and learners.
Prompting authentic blogging practice in an online graduate course
Authors: Freeman Wendy , Brett Clare
Published: September 2023

Blogging is characterized by an individual exploration of ideas of personal interest through frequent online posts, documenting ideas as they emerge over time. Community emerges as bloggers read and link across blogs, based on shared interests. Blogs have gained acceptance in higher education for a variety of instructional activities, among which, reflective journal writing is popular. In this study, we examine a project in which blogs were implemented within an online graduate course in order to create opportunities for students to reflect on their academic, professional and personal interests, with the goal of establishing consistent blogging that exhibits the timely, frequent and interest-driven practices of blogging practices outside educational contexts. Students enrolled in an online graduate course maintained individual blogs in which they were prompted to write about their interests and experiences as graduate students. Through an analysis of the patterns of prompt use and blog content, as well as data from a post-course survey and an online discussion, we explore how to support student engagement with blogging practice within an educational setting. Findings suggest that frequency of writing, topic resonance with the students own interests, and the timeliness of entries were key factors in scaffolding writing that aligns with blogging practice. By focusing on writing as characterized by authentic blogging practice, this study contributes to an understanding of how to harness the unique communicative elements of the blog in post-secondary settings.
In Search of a “Newer and Truer” Literature: Thomas Phillips Thompson and The Labor Advocate
Authors: Buchanan David
Published: September 2023

This article describes the uses of literature in The Labor Advocate: A Weekly Labor Reform Newspaper (Toronto, 1890-91). As editor of the Advocate, Thomas Phillips Thompson aimed to increase awareness of the means and consequences of industrial capitalism, and thus enhance the possibility of social justice for the working class. He did so in a mixed format periodical that included poetry, short fiction, and serialized novels as well as editorials, biographies, obituaries, reports, letters, and columns. Over forty-four issues, Thompson experimented with literary expression to attract readers and foster the democratic reform of social organization. Analysis of the Advocate points to the importance of communication strategies in both the early history of the Canadian labour press and the longer history of labour in transnational contexts.
Karya Tari Sang Kustiah Refleksi Perempuan pada Masa Kini
Authors: Wisnu Pamenang Nandhang , Dewi Maharani Luthvinda , Samsuri Samsuri
Published: September 2023

Kustiah’s dance works contain values and can be used as a reference in current and future life. One of them is that Kustiah’s dance work includes the importance of Unity, Creativity, Tough, and Abstinence, which are philosophical teachings that are upheld and can serve as role models for women at this time in moving forward in their lives. This value can be adhered to and carried out, ultimately giving women a strong character and soul.Keywords: Dance work, Kustiah, reflextion, women.
Kolaborasi Karya Tari Suara Hati
Authors: Supendi Eko , Sri Kuncoro Jonet , Suroto Suroto
Published: September 2023

Research on art creation entitled Suara Hati Dance Collaboration involving dancers (students) and children with visual impairments (disabilities) to answer concerns about how a dancer feels dancing in the dark. This research method is a collaboration between the potential of dancers and the artistic potential of blind children. The dancers’ explorations were inspired by the behavior of the character Gendari in the  Mahabarata story, who closed his eyes all his life only to feel the same darkness as his husband, Destrarastra. Exploring the potential of blind children is an important part of this research to determine the process and form of work. The results of this study provide an artistic experience for dancers, moving in the dark just following their auditory instincts. Providing space for expression and artistic experience for blind children, fostering self-confidence, courage, and a sense of pride in being able to work with dancers and appear in performances that are shown publicly.Keywords: voice, heart, collaboration, visual impairment, Gendari, movement, darkness.
Intellectual potential as the main factor of innovative development of an enterprise
Authors: Arefieva O. V , Kovalenko N. V , Andriienko M. M
Published: September 2023

Methods. In conducting a study of the intellectual potential of an enterprise, the article uses the method of scientific abstraction to define theoretical and methodological approaches to the essence of the concept of «intellectual potential», system approach to use a methodological approach to the components of the process of managing the efficiency of the intellectual potential of an enterprise. Results. The composition of the economic category of «intellectual potential» is determined on the basis of generalization of characteristics based on scientific developments of researchers on effective management at an enterprise. It has been found that the existing contradictions between the object and subject in the process of intellectual potential management should be resolved with the help of economic instruments: purpose, goal, principles, methods, ways and indicators of enterprise performance evaluation. Novelty. The article proposes a methodical approach to effective management of the intellectual potential of an innovative enterprise, the essence of which is a systematic step-by-step assessment of economic instruments aimed at harmonizing production and economic interests between objects and subjects in the course of creating high-tech products. The structural composition of the process of balancing the harmonization of production and economic interests between the subject and the object in the field of innovation activity includes: goals and objectives of development of an innovative enterprise, tools for ensuring the efficient use of the intellectual potential of an enterprise, principles for ensuring the efficiency of use of the intellectual potential of the enterprise and expected results in the form of knowledge-intensive products. Practical value. Based on the results of the scientific research, the author proposes economic guidelines for managing the intellectual potential of an innovative enterprise, which will help to resolve the existing contradictions in the implementation of production and economic activities and will contribute to the development of innovative areas of work.
Systemic mastocytosis associated with acute myeloid leukaemia
Authors: Nazihah Mohd Nasiruddin Dhamirah , Suriana Wan Ab Rahman Wan , Arbaeyah Hussain Faezahtul , Azlan Husin , Syazwani Saidin Nur Ilyia , Nazri Hassan Mohd , Zefarina Zulkafli , Shafini Mohamed Yusof , Salfarina Iberahim , Haslina Mohd Noor Noor
Published: September 2023

Bacground: The pathogenesis of systemic mastocytosis with associated haematological neoplasm (SMAHN) is not well understood. Both diagnoses heavily rely on morphological evaluation because SM is rarely suspected in clinical practise.
Objective: This case highlighted a possible delay in diagnosis due to underlying conditions or diseases.
Case Report: We present a case of a patient with acute myeloid leukaemia (AML), acute myelomonocytic subtype, and concurrent mastocytosis according to World Health Organization (WHO) classification. Due to an extensive accumulation of AML blast cells that obscured the mast cell infiltrates, mastocytosis was not evident at the first diagnosis.
Discussion and conclusion: The diagnosis, in this case, was established only in the third bone marrow biopsy after chemotherapy. A high index of suspicion with morphological and immunohistochemical evaluations for neoplastic mast cell populations should be considered. The optimal treatment approach should be chosen based on these two disease entities.
Bangladesh Journal of Medical Science Vol. 22 No. 04 October’23 Page : 937-941
Pemberdayaan Kelompok Tani Masyarakat dalam Pemanfaatan Limbah Sayuran sebagai Bahan Baku Pakan Ayam
Authors: Fitasari Eka , Mushollaeni Wahyu , Rahmawati Atina
Published: September 2023

Sayuran sisa hasil panen dan penjualan dianggap sebagai limbah oleh para petani sayur Siswandi di Pujon Malang. Limbah sayuran dibiarkan menumpuk, dipinggirkan ke gudang, atau dibuang, sehingga jika membusuk akan mengakibatkan pencemaran dan bau yang menyengat. Padahal, sayuran sisa tersebut masih mengandung zat gizi makro dan mikro yang dapat dimanfaatkan sebagai bahan pakan ayam. Pakan pelet sangat dibutuhkan oleh peternak ayam Sumber Rejeki di Singosari Malang. Harga pelet pabrik yang mahal, mengakibatkan ayam diberikan pakan dari makanan sisa untuk menekan biaya produksi. Berdasarkan permasalahan tersebut, dibutuhkan sinergitas dari petani sayur dan peternak melalui pelatihan pembuatan pelet yang mudah dibuat dan berdaya simpan lama, dengan memanfaatkan limbah sayur, serta penanganan pasca panen sayur. Hasil kegiatan menunjukkan peningkatan keterampilan kedua kelompok tani dalam membuat pelet pakan ayam, serta peningkatan pendapatan peternak dengan produksi karkas ayam dalam kemasan vakum dan petani sayur dengan produksi sayur dalam kemasan.
Workshop Peran Siswa sebagai Warga Negara Dalam Menyikapi Realitas di Masa Pandemi
Authors: Hubi Zindan Baynal , Pangestu Ilham Aji , Adhari Nursanda Rizki , Fahmi Rizal
Published: September 2023

Pelaksanaan Pengabdian Kepada Masyarakat (PKM) ini bertujuan diantaranya pertama menumbuhkan kecerdasan  dan kecakapan kewarganegaraan terkait dengan peran warga negara muda menghadapi pandemi Covid-19,  kedua kecakapan dan kesadaran kewarganegaraan tersebut diimplementasikan ketika mampu bersikap efektif didalam tindakan serta mampu mengaktualisasikan nilai-nilai Pancasila dalam menghadapi pandemi Covid-19, dan ketiga mitra mampu berperan dalam menyikapi realitas dimasa pandemi termasuk dengan kebajikan yang dilakukan. Mitra dalam PKM ini adalah para siswa SMAN 20 Kabupaten Tangerang. Metode pelaksanaan yang digunakan yaitu penyuluhan dalam bentuk ceramah melalui media googlemeet. Dalam PKM ini materi yang disampaikan meliputi kesadaran bela negara ditengah pandemi, aktualisasi nilai Pancasila menjadi relevan dengan situasi hari ini, dan bagaimana siswa dapat berperan serta dalam menyikapi realitas dimasa pandemi. Adapun kesimpulan dalam materi ini menekankan pada konsep triple helix concept, dimana pemerintah dengan political power, akademisi/ pelajar dengan knowledge power dan masyarakat dengan social control, harus senantiasa bersinergi bersama dalam menanggulangi pandemi ini. Dampak dengan diadakannya workshop kegiatan terhadap Siswa SMAN 20 Kabupaten Tangerang, tidak lain sedikitnya merupakan salah satu upaya untuk menumbuhkan kecakapan kewarganegaraan utamanya terhadap warga negara muda. Kecakapan warga negara itu harus ditimbulkan dan disadarkan melalui pendidikan ataupun contoh nyata yang dilakukan berbagai elemen bangsa. Adapun rekomendasi terhadap pelaksnaan PKM ini kedepan diantaranya adalah pertama, adanya kegiatan lanjutan yang melibatkan komponen masyarakat, kedua, melakukan pendampingan secara langsung dengan memperhatikan protokol kesehatan, dan ketiga, singkronisasi yang lebih luas khususnya instansi pemerintah.
Penerapanan Analisis Twin dalam Pengembangan Desa Wisata di Desa Bokor, Kecamatan Tumpang, Kabupaten Malang
Authors: Nurlaelih Euis Elih , Sitawati Sitawati , Aini Nurul , Sugito Yogi , Santoso Mudji , Baskara Medha , Damaiyanti Dewi Ratih Rizki
Published: September 2023

Desa Bokor merupakan salah satu wilayah di Kecamatan Tumpang, Kabupaten Malang yang berpotensi untuk dikembangkan menjadi Desa Wisata.TWIN (Tani, Wisata, Indah, dan Nyaman) merupakan analisis potensi yang sering digunakan dalam pengembangan agrowisata yang diaplikasikan pada pengembangan Desa Wisata Bokor. Pengabdian masyarakat ini dilaksanakan melalui tahap kegiatan survei lokasi, komunikasi dan sosialisasi, FGD serta pendampingan.Tujuan yang ingin dicapai adalah adanya peningkatan pemahaman dan kesamaan visi misi antar elemen masyarakat Desa Bokor serta tersusunnya rencana pengembangan Desa Wisata berbasis pertanian. Kegiatan dilakukan pada bulan Mei sampai September 2020. Hasil analisis TWIN, Desa Bokor memiliki potensi yang besar untuk dikembangkan sebagai desa wisata berbasis pertanian dan perikanan yang ditunjang oleh budaya dan kearifan lokal. Potensi utama yang dimiliki antara lain pemandangan alam yang indah, suasana perdesaan yang alami dan asri, aksesibilitas yang mudah, masyarakat desa yang ramah serta adanya fitur atau elemen lanskap baik alami maupun budaya seperti sungai, sawah, dan perkampungan khas perdesaan. Rekomendasi yang diberikan antara lain terkait penataan area pemancingan serta fasilitas pendukung desa wisata lainnya.
Upaya Optimalisasi Tata Kelola Organisasi yang Efektif Desa Jeblog, Kecamatan Karanganom, Kabupaten Klaten: Pendekatan Prinsip Good Corporate Governance (GCG)
Authors: Pradana Handrio Adhi , Setyaning Alldila Nadhira Ayu , Pahlevi Reza Widhar
Published: September 2023

Desa Jeblog, Kecamatan Karanganom, Kabupaten Klaten merupakan kawasan Minapolitan dimana dominasi usaha warga desa pada industri peternakan ikan dan pengolahan hasil ikan khususnya ikan nila. Selain industri kecil rumahan, pertanian, dan perdagangan, industri ternak ikan nila telah menjadi mata pencaharian utama yang turun-temurun dari sejarah Desa Jeblog sendiri. Keuntungan secara geografis, letak Desa Jeblog yang berdekatan dengan salah satu sumber mata air jernih di Kecamatan Karanganom yakni umbul Ponggok di Desa Ponggok. Meskipun dengan dukungan sumber daya lingkungan yang melimpah, Desa Jeblog dinilai belum mampu mengoptimalkan menjadi sebuah ekosistem pariwisata dan kewirausahaan yang terintegrasi. Program pengabdian ini merupakan bagian dari rangkaian program kerjasama unit PPM Jurusan Manajemen FBE UII kemitraan Desa Jeblog untuk membantu mewujudkan tujuan besar Desa Jeblog sebagai ikon desa wisata nila. Tujuan kegiatan ini adalah penyuluhan dan pendampingan terkait tata kelola organisasi desa yang efektif sebagai bentuk penguatan pilar internal yang mendukung capaian tujuan Desa Jeblog sebagai ikon desa wisata Nila. Berdasarkan capaian pelaksanaan dari program penyuluhan dan pendampingan tata kelola organisasi desa yang efektif dapat dikategorikan sangat baik karena mampu memunculkan keterlibatan penuh dan komitmen tinggi perangkat desa dan pengelola BUMDes untuk mewujudkan tata kelola organisasi desa yang ideal.
Workshop Literasi Digital sebagai Sumber Referensi Ilmiah dan Mengajar bagi Guru Bahasa Indonesia Tingkat SMP dan SMA di Kabupaten Bengkulu Tengah
Authors: Wardhana Dian Eka Chandra , Danim Sudarwan , Noermanzah Noermanzah
Published: September 2023

Banyak guru bahasa Indonesia tingkat SMP dan SMA di Kabupaten Bengkulu Tengah yang belum memahami tugasnya dalam literasi digital. Pengabdian kepada masyarakat ini bertujuan mendeskripsikan hasil workshop literasi digital sebagai sumber referensi ilmiah dan mengajar bagi guru bahasa Indonesia tingkat SMP dan SMA di Kabupaten Bengkulu Tengah. Workshop ini dilakukan secara daring melalui Zoom Cloud Meeting selama 4 hari atau setara 32 jam dari tanggal 27 sampai dengan 30 September 2021. Workshop ini dilaksanakan atas dasar kerja sama antara Program Magister (S-2) Pendidikan Bahasa Indonesia, FKIP Universitas Bengkulu dengan MGMP Bahasa Indonesia SMP Kabupaten Bengkulu Tengah. Workshop ini menghasilkan 86% peserta menerima pemahaman materi tentang literasi digital dengan kriteria baik dan 82% peserta memahami dengan baik tentang cara menggunakan aplikasi pembelajaran. Kemudian, 35% peserta workshop sudah mampu memproduksi media pembelajaran atau sejenisnya dengan menggunakan aplikasi Mendeley, Google Form, VideoScribe Sparkol, Render Forest, Zoho Forms, Media Padlet, dan Camtasia.
Desain Ruang Kelas yang Efektif untuk Menghafal di Sekolah Tahfiz Setaba Utsman
Authors: Putri Sri Andika , Lestari Elly
Published: September 2023

Desain ruang pembelajaran yang sesuai dengan kebutuhan dan usia anak menjadi salah satu faktor yang dapat mendukung tercapainya target pembelajaran bagi siswa di sekolah. Sekolah Setaba Utsman merupakan salah satu sekolah swasta yang bertujuan memberikan hafalan Al-Quran kepada siswa. Sistem yang digunakan adalah bermain sambil belajar. Untuk mendukung hal ini perlu dilakukan desain ruang kelas yang menarik dan sesuai dengan pembelajaran siswa. Tujuan PKM ini adalah untuk memberikan kenyaman dan memotivasi siswa agar lebih giat lagi menghafal Al-Quran dengan adanya desain ruang kelas yang mendukung pembelajaran. Dengan pembuatan desain ruang kelas diharapkan siswa bisa lebih betah berada di dalam kelas sambil mendengarkan ayat-ayat Al-Quran untuk hafalan mereka.
Teh Daun Kelor Sebagai Inovasi Dan Peningkatan Nutrisi Pangan Khas Indonesia
Authors: Mulyana Deden , Listiana Elis , Lestary Deasy , Bintari Vivi Indah
Published: September 2023

Pandemi Covid-19 memiliki dampak pada semua sektor, sehingga dirasakan pula oleh warga kampung Anaka, Kelurahan Urug, Kecamatan Kawalu, Kota Tasikmalaya. Pada tahun 2020, para pemuda sekitar melihat potensi alam yang indah, sehingga berinisiatif untuk menyulap sebuah bukit menjadi lokasi wisata alam baru bernama Bukit Nangela dengan pemandangan Kawasan hutan milik perhutani. Dengan rencana jangka panjang untuk menjadi Kampung Wisata Anaka. Namun, perlu adanya ciri khas kuliner tertentu yang akan menaikan trend positif berkunjung masyarakat. Mata pencaharian utama di Kelurahan Urug adalah sebagai buruh tani. Terdapat hasil pertanian yang masih belum terolah oleh masyarakat untuk dijadikan produk unggulan yaitu daun kelor. Masyarakat belum mengetahui bagaimana cara pengolahan daun kelor agar dapat dikonsumsi dengan bantuan teknologi secara sederhana. Untuk menyelesaikan permasalahan tersebut, maka kegiatan pengabdian masyarakat dengan Skema Ketahanan Pangan (PbM-KP) telah dirancang solusinya yaitu 1) Pendampingan dan pemberian biaya  untuk sarana produksi pengolahan teh daun kelor,  2) Pelatihan pengolahan daun kelor menjadi teh daun kelor siap jual, dan 3) Pemasaran produk pertanian dengan membuatkan kemitraan dengan pedagang kuliner disekitar bukit nangela sehingga menjadi produk unggulan desa wisata dan melakukan pemasaran secara online. Tujuan dari kegiatan ini adalah produksi olahan daun kelor yaitu teh daun kelor siap dipasarkan, sehingga menjadi produk olahan unggulan di Kampung Anaka Keluarahan Urug. Berdasarkan hasil kegiatan yang dilakukan bahwa masyarakat antusias dan memanfaatkan teh daun kelor menjadi minuman olahan.
Pengembangan Usaha Pudot Bergizi Sebagai Upaya Penguatan Ekonomi Mandiri Ibu PKK
Authors: Putri Ronasari Mahaji , Fitasari Eka , Putri Sri Andika , Devi Hilda Mazarina
Published: September 2023

PKK RT 06 RW 09 merupakan salah satu perkumpulan ibu yang berada di daerah Landungsari Malang, beranggotakan 40 ibu. Sebanyak 2 dari 40 ibu telah memiliki usaha sampingan dirumah yakni berupa toko perancangan, dan catering. Sedangkan ibu yang lainnya ada yang bekerja di luar rumah, dan ada yang sebagai ibu rumah tangga. Sebagian besar ibu di daerah tersebut mempunyai putra putri yang masih kecil dan sangat mendukung kegiatan yang dapat menambah keahlian dan ketrampilan ibu sebagai upaya untuk meningkatkan gizi keluarganya, termasuk juga dapat meningkatkan perekonomian keluarga. Banyaknya waktu ibu saat di rumah memungkinkan para ibu untuk lebih berkreasi, baik yang mendatangkan materi ataupun tidak, namun memberikan manfaat bagi keluarganya. Pengabdi mengambil kesempatan untuk dapat memberikan manfaat bagi Ibu PKK RT 06 RW 09 Landungsari. Solusi yang ditawarkan oleh pengabdi adalah membuat usaha puding sedot bergizi, yang relatif diminati oleh pangsa pasar, dengan biaya yang murah, bahan baku yang mudah untuk diakses, serta manfaat yang didapatkan dengan berproduksi pudot yakni memberikan gizi yang baik untuk keluarga dan calon konsumen. Kegiatan pengabdian masyarakat berupa pelatihan usaha pudot (puding sedot) telah berjalan di bulan Maret 2022 dan diharapkan menjadi salah satu ketrampilan yang dikuasai ibu ibu PKK  sebagai bekal dalam membangun ekonomi mandiri ibu RT.
Relationship between Side Effects of Anti-tuberculosis Drugs (ATDs) and Adherence to Medication in Elderly Patients with Tuberculosis
Authors: Pramono Joko Sapto , Sudding Riana , Tini Tini
Published: September 2023

One of the obstacles to the treatment of tuberculosis (TB) patients is the sideeffects of anti-tuberculosis drugs (ATDs) which cause patients to be reluctant to continue the medication. The elderly experience various physical and physiological changes in the bodysystem, including susceptibility to drug side effects, decreased knowledge and memory,resulting in non-compliance with taking the medication. This study aims to determine therelationship between ATDs side effects and compliance with taking medication for elderlypatients at the Tanjung Selor Health Center, Bulungan Regency, North Kalimantan Province.This study used a quantitative cross-sectional approach. The sample was taken by totalpopulation, namely elderly tuberculosis patients undergoing tuberculosis treatment as many as30 respondents. The research instrument was a questionnaire of drug side effects and ATDscompliance. Statistical test used Fisher's Exact. The results showed that most patients (76.7%)complained of OAT side effects and the rest without OAT side effects (23.3%). Treatmentcompliance was 20% compliant, and 80% were non-compliant. Fisher's Exact statistical testobtained p-value = 0.016 (< α = 0.05). It was concluded that there was a significant relationship between OAT side effects and treatment compliance in elderly patients with tuberculosis. Recommendations for health workers to give special attention to elderly patients with medication monitoring and compliance motivation. Future researchers should identify the involvement of family and health workers to monitor the side effects of anti-tuberculosis drugs.
Parameter-uniformly convergent numerical scheme for singularly perturbed delay parabolic differential equation via extended B-spline collocation
Authors: Hassen Zerihun Ibrahim , Duressa Gemechis File
Published: September 2023

This paper presents a parameter-uniform numerical method to solve the time dependent singularly perturbed delay parabolic convection-diffusion problems. The solution to these problems displays a parabolic boundary layer if the perturbation parameter approaches zero. The retarded argument of the delay term made to coincide with a mesh point and the resulting singularly perturbed delay parabolic convection-diffusion problem is approximated using the implicit Euler method in temporal direction and extended cubic B-spline collocation in spatial orientation by introducing artificial viscosity both on uniform mesh. The proposed method is shown to be parameter uniform convergent, unconditionally stable, and linear order of accuracy. Furthermore, the obtained numerical results agreed with the theoretical results.
Overcoming extended lag phase on optically pure lactic acid production from pretreated softwood solids
Authors: Campos Joana , Almqvist Henrik , Bao Jie , Wallberg Ola , Lidén Gunnar
Published: September 2023

Optically pure lactic acid (LA) is needed in PLA (poly-lactic acid) production to build a crystalline structure with a higher melting point of the biopolymer than that of the racemic mixture. Lignocellulosic biomass can be used as raw material for LA production, in a non-food biorefinery concept. In the present study, genetically engineered P. acidilactici ZP26 was cultivated in a simultaneous saccharification and fermentation (SSF) process using steam pretreated softwood solids as a carbon source to produce optically pure D-LA. Given the low concentrations of identifiable inhibitory compounds from sugar and lignin degradation, the fermentation rate was expected to follow the rate of enzymatic hydrolysis. However, added pretreated solids (7% on weight (w/w) of water-insoluble solids [WIS]) significantly and immediately affected the process performance, which resulted in a long lag phase (more than 40 h) before the onset of the exponential phase of the fermentation. This unexpected delay was also observed without the addition of enzymes in the SSF and in a model fermentation with glucose and pretreated solids without added enzymes. Experiments showed that it was possible to overcome the extended lag phase in the presence of pretreated softwood solids by allowing the microorganism to initiate its exponential phase in synthetic medium, and subsequently adding the softwood solids and enzymatic blend to proceed to an SSF with D-LA production.
The Arf-GEF GBF1 undergoes multi-domain structural shifts to activate Arf at the Golgi
Authors: Meissner Justyna M. , Akhmetova Katarina , Szul Tomasz , Viktorova Ekaterina G. , Sha Bingdong , Bhatt Jay M. , Lee Eunjoo J. , Kahn Richard A. , Belov George A. , Chesnokov Igor , Sztul Elizabeth
Published: September 2023

Golgi homeostasis require the activation of Arf GTPases by the guanine-nucleotide exchange factor requires GBF1, whose recruitment to the Golgi represents a rate limiting step in the process. GBF1 contains a conserved, catalytic, Sec7 domain (Sec7d) and five additional (DCB, HUS, HDS1-3) domains. Herein, we identify the HDS3 domain as essential for GBF1 membrane association in mammalian cells and document the critical role of HDS3 during the development of Drosophila melanogaster. We show that upon binding to Golgi membranes, GBF1 undergoes conformational changes in regions bracketing the catalytic Sec7d. We illuminate GBF1 interdomain arrangements by negative staining electron microscopy of full-length human GBF1 to show that GBF1 forms an anti-parallel dimer held together by the paired central DCB-HUS core, with two sets of HDS1-3 arms extending outward in opposite directions. The catalytic Sec7d protrudes from the central core as a largely independent domain, but is closely opposed to a previously unassigned α-helix from the HDS1 domain. Based on our data, we propose models of GBF1 engagement on the membrane to provide a paradigm for understanding GBF1-mediated Arf activation required for cellular and organismal function.
Rock physics and machine learning comparison: elastic properties prediction and scale dependency
Authors: Suleymanov Vagif , El-Husseiny Ammar , Glatz Guenther , Dvorkin Jack
Published: September 2023

Rock physics diagnostics (RPD) established based upon the well data are used to deterministically predict elastic properties of rocks from measured petrophysical rock parameters. However, with the recent advances in statistical methods, machine learning (ML) can help to build a shortcut between raw well data and rock properties of interest. Several studies have reported the comparison of rock physics and machine learning methods for the prediction of rock properties, but the scale dependence of the ML models was never investigated. This study aims at comparing the results from rock physics and machine learning models for predicting elastic properties such as bulk density (ρb), P-wave velocity (Vp), S-wave velocity (Vs), as well as Poisson’s ratio (v) and acoustic impedance (Ip) in a well from the Gulf of Mexico (GOM) in two different scale scenarios: the well log and seismic scales. The well data under examination was split into training and testing subsets to optimize and test the developed ML models. The RPD approach was also used to validate and compare the accuracy of predicted elastic properties. Backus averaging was later applied to upscale the well data to the seismic scale to examine the scale dependence and prediction accuracy of aforementioned physics-driven and data-driven approaches. Results show that RPD and ML methods provided consistent results at both well log and seismic scales, suggesting the scale independence of both approaches. Moreover, ML models showed better estimation of rock properties due to their “apparent” match with measured data at both scales compared to the RPD approach where a significant mismatch between measured and predicted rock properties was found in the reservoir section of the well. However, by conducting further quality control of the sonic data, it was found that the measured Poisson’s ratio was extremely high in the gas-saturated interval. Hence, the prediction from ML models in this particular case cannot be trusted as ML models were trained based on poor-quality well data with non-realistic Vs and v values. Such an issue, however, could be identified and corrected using RPD as presented in this study. We demonstrate the importance of incorporating domain knowledge, i.e., rock physics, to check data quality and validate results from data-driven models.
Integration of white rot mushroom cultivation to enhance biogas production from oil palm kernel pulp by solid-state digestion
Authors: Panngoen Pathompong , Leksawasdi Noppol , Rachtanapun Pornchai , Chakrabandhu Yasinee , Jinsiriwanit Siriwat
Published: September 2023

Solid-state fermentation is one of the promising technologies for biogas production because of its low water footprint and solid output which is potentially used in fuel or agricultural applications. Oil palm kernel pulp (OPKP) is a by-product generated from the extraction of palm kernel oil from the mesocarp of the oil palm tree and usually contains a large amount of lignocellulose and moderate protein content, which makes it suitable for use as a mushroom substrate. Cultivation of white rot mushrooms on lignocellulose may enhance its biodegradation by biodelignification. In this study, the incorporation of the cultivation of edible white rot mushrooms, Pluerotus ostreatus and Pleurotus pulmonarius, to enhance biogas production by solid-state digestion was studied. The biological efficiency of mushroom production from the OPKP substrate of P. ostreatus and P. pulmonarius was 49.81% ± 11.28% and 46.94% ± 13.49%, respectively, corresponding to the substrate weight loss of 15.87% and 13.92%. After 30 days, methane yield obtained through the solid-state digestion of P. ostreatus- and P. pulmonarius-treated OPKP substrates was increased to 98.11 mL/gVS (191%) and 101.10 mL/gVS (197%), respectively, compared with the untreated OPKP substrate. In consideration of energy loss during the biological conversion, the calorific values of the OPKP substrate, P. ostreatus-treated OPKP substrate, and P. pulmonarius-treated OPKP substrate were 11.03 ± 0.71 kJ/g, 9.30 ± 0.23 kJ/g, and 8.83 ± 0.70 kJ/g, respectively, while those of the digestion residues of P. ostreatus and P. pulmonarius-treated OPKP substrates were 8.45 ± 0.13 kJ/g and 8.55 ± 0.11 kJ/g, respectively.
Advances on layered transition-metal oxides for sodium-ion batteries: a mini review
Authors: Lu Jinlin , Zhang Jinwen , Huang Yingying , Zhang Yi , Yin Yansheng , Bao Shuo
Published: September 2023

The energy storage mechanism and manufacturing equipment of sodium-ion batteries (SIBs) and lithium-ion batteries (LIBs) are similar. However, SIBs offer several advantages, such as low cost, abundant resources, environmental friendliness, and high safety. Consequently, they have garnered significant attention. SIBs are poised to be potential replacements for LIBs and represent ideal candidates in the field of large-scale energy storage. Layered transition-metal oxides (TMOs) are considered highly promising cathode materials due to their high average voltage, high specific capacity, and ease of synthesis. This paper provides a review of recent advances in layered TMOs for SIBs, including NaxCoO2, NaxMnO2, NaxFeO2, and their derivatives. Furthermore, the challenges and prospects in the development of layered TMOs are also discussed. It is hoped that this review will assist in the design and preparation of SIBs with superior electrochemical performance and further facilitate their practical application.
SWAT model-based quantification of the impact of land use land cover change on sediment yield in the Fincha watershed, Ethiopia
Authors: Regasa Motuma Shiferaw , Nones Michael
Published: September 2023

In recent years, Ethiopia is facing problems due to soil erosion, mainly because of the conversion of natural vegetation into cultivated land to answer to increasing human pressure. Such changes in coverage are fostering soil erosion, which is also affecting dam reservoirs, because of the increasing sediment yield entering the lake. The present study focuses on the Ethiopian Fincha watershed and takes advantage of the potentiality of the Soil and Water Assessment Tool (SWAT) model, to investigate how land use land cover changes impact soil erosion and the consequent sediment yield entering the Fincha Dam. The SWAT model was calibrated and validated using time series data of stream flow and sediment covering the period 1986-2008, and its performance was evaluated by looking at the coefficient of determination, Nash-Sutcliffe simulation efficiency, and per cent bias. Once validated, the SWAT model was applied to derive sediment yield for the future 30 years, based on forecasted land use land cover conditions. The results show that the mean annual soil loss rate increased from 32.51 t ha−1 in 1989 to 34.05 t ha−1 in 2004, reaching 41.20 t ha−1 in 2019. For the future, a higher erosion risk should be expected, with the annual soil loss rate forecasted to be 46.20 t ha−1 in 2030, 51.19 t ha−1 in 2040, and 53.98 t ha−1 in 2050. This soil erosion means that sediments transported to the Fincha Dam, located at the watershed outlet, increased significantly in the last 30 years (from 1.44 in 1989 to 2.75 mil t in 2019) and will have the same trend in the future (3.08–4.42 mil t in 2020 and 2050, respectively), therefore highly affecting the Fincha reservoir services in terms of reduction of water volume for irrigation and hydroelectric power generation. By providing possible medium/long-term scenarios, the present work can help land planners and decision-makers in developing future land management strategies based on actual projections, eventually aiming to reduce soil erosion at the watershed scale and guarantee the sustainable development of the Fincha region and its key hydraulic infrastructures.
Deciphering the spatiotemporal trade-offs and synergies between ecosystem services and their socio-ecological drivers in the plain river network area
Authors: Xu Haishun , Cheng Jiaqing , Guo Yanping , Zhong Tongxin , Zhang Jinguang
Published: September 2023

Understanding changes in ecosystem services (ESs) and quantitatively identifying the drivers that influence these changes are essential for achieving sustainable ecosystem development. In this study, multiple data sources and techniques, including meteorological data, land use/cover data, soil data, the InVEST model, and ArcGIS, were used to analyze the spatiotemporal variation characteristics of carbon storage, habitat quality, soil retention, water yield, and crop product supply in Xinghua City from 2000 to 2015. Additionally, we explored the causes of these changes and the interrelationships among these ESs. The results showed that: (1) During the study period, carbon storage and habitat quality declined, water yield fluctuated and increased, and soil retention had small interannual variations. The supply capacity of crop products first increased rapidly and then stabilized. (2) ESs were influenced by multiple drivers, with altitude having the strongest explanatory power for habitat quality and soil retention, and food production having the strongest explanatory power for crop product supply. (3) Relationships between different ESs were variable and changed over time. This study could enrich the understanding of spatial and temporal changes and drivers of ESs in the plain river network area, which has important implications for future land use planning and sustainable development of ESs.
ABCA4 c.6480-35A>G, a novel branchpoint variant associated with Stargardt disease
Authors: Rodríguez-Hidalgo María , de Bruijn Suzanne E. , Corradi Zelia , Rodenburg Kim , Lara-López Araceli , Valverde-Megías Alicia , Ávila-Fernández Almudena , Fernandez-Caballero Lidia , Del Pozo-Valero Marta , Corominas Jordi , Gilissen Christian , Irigoyen Cristina , Cremers Frans P. M. , Ayuso Carmen , Ruiz-Ederra Javier , Roosing Susanne
Published: September 2023

Introduction: Inherited retinal dystrophies (IRDs) can be caused by variants in more than 280 genes. The ATP-binding cassette transporter type A4 (ABCA4) gene is one of these genes and has been linked to Stargardt disease type 1 (STGD1), fundus flavimaculatus, cone–rod dystrophy (CRD), and pan-retinal CRD. Approximately 25% of the reported ABCA4 variants affect RNA splicing. In most cases, it is necessary to perform a functional assay to determine the effect of these variants.

Methods: Whole genome sequencing (WGS) was performed in one Spanish proband with Stargardt disease. The putative pathogenicity of c.6480-35A>G on splicing was investigated both in silico and in vitro. The in silico approach was based on the deep-learning tool SpliceAI. For the in vitro approach we used a midigene splice assay in HEK293T cells, based on a previously established wild-type midigene (BA29) containing ABCA4 exons 46 to 48.

Results: Through the analysis of WGS data, we identified two candidate variants in ABCA4 in one proband: a previously described deletion, c.699_768+342del (p.(Gln234Phefs*5)), and a novel branchpoint variant, c.6480-35A>G. Segregation analysis confirmed that the variants were in trans. For the branchpoint variant, SpliceAI predicted an acceptor gain with a high score (0.47) at position c.6480-47. A midigene splice assay in HEK293T cells revealed the inclusion of the last 47 nucleotides of intron 47 creating a premature stop codon and allowed to categorize the variant as moderately severe. Subsequent analysis revealed the presence of this variant as a second allele besides c.1958G>A p.(Arg653His) in an additional Spanish proband in a large cohort of IRD cases.

Conclusion: A splice-altering effect of the branchpoint variant, confirmed by the midigene splice assay, along with the identification of this variant in a second unrelated individual affected with STGD, provides sufficient evidence to classify the variant as likely pathogenic. In addition, this research highlights the importance of studying non-coding regions and performing functional assays to provide a conclusive molecular diagnosis.
Plasma YKL-40 is associated with prognosis in patients with metastatic pancreatic cancer receiving immune checkpoint inhibitors in combination with radiotherapy
Authors: Johansen Astrid Z. , Novitski Sif I. , Hjaltelin Jessica X. , Theile Susann , Boisen Mogens K. , Brunak Søren , Madsen Daniel H. , Nielsen Dorte L. , Chen Inna M.
Published: September 2023

Background

YKL-40, also known as chitinase-3-like protein 1 (CHI3L1), is a secreted glycoprotein produced by various cell types including stromal, immune, and cancer cells. It contributes to cancer progression through tumor-promoting inflammation and has been shown to inhibit the cytotoxicity of T and NK lymphocytes. In vivo studies have demonstrated synergistic anti-cancer effects of blocking YKL-40 in combination with immune checkpoint inhibitors (ICIs). Biomarkers for the prediction of the response to ICIs are highly needed. We investigated the association between plasma YKL-40 and clinical benefit and survival in patients with metastatic pancreatic cancer (mPC) receiving ICIs and stereotactic body radiotherapy (SBRT).

Methods

Blood samples were collected from 84 patients with mPC who participated in the randomized phase II CheckPAC study, in which patients received nivolumab with or without ipilimumab combined with a single fraction of SBRT. Plasma YKL-40 was measured using a commercial ELISA kit.

Results

Elevated baseline plasma YKL-40 was an independent predictor of shorter overall survival (OS) (HR 2.19, 95% CI 1.21–3.95). A ≥ 40% decrease in plasma YKL-40 during treatment was associated with longer progression-free survival (p = 0.009) and OS (p = 0.0028). There was no correlation between plasma YKL-40 and the tumor burden marker CA19-9 at baseline or during treatment.

Conclusion

This study contributes new knowledge regarding YKL-40 as a predictor of clinical benefit from ICIs and radiotherapy. These exploratory results warrant further investigation of YKL-40 as a biomarker for patients treated with immunotherapies.

Clinical trial registration

Clinicaltrials.gov, identifier NCT02866383.