bluuebunny/crossref_metadata_2025 huggingface dataset:
Upaya Peningkatan Edukasi terhadap Masyarakat Mengenai Penyakit Infeksi Kulit dan Pengobatan di Desa Limbangan Kec. Wanareja Kab. Cilacap Jawa Tengah
Authors: Wulandari Winda Trisna , Rijkiyah Gina Sheli , Yassinqi Manita Cenda , Nurfadhilla Dilla , Muhtar Muhammad Wildan , Augie Andrea , Maolana Ananda
Published: May 2024

ABSTRAK Penyakit infeksi kulit adalah penyakit kulit yang disebabkan oleh mikroorganisme seperti virus, jamur, bakteri dan parasite. Kulit merupakan pelindung beberapa organ yang ada di dalam tubuh dan bagian tubuh yang cukup sensitive terhadap beberapa penyakit. Penyuluhan yang dilakukan bertujuan untuk meningkatkan pengetahuan dan kepedulian masyarakat Desa Limbangan Kec. Wanareja Kab. Cilacap Jawa Tengah untuk tetap menjaga kebersihan dan lingkungan sekitar serta pengobatan dari penyakit infeksi kulit. Pelaksanaan kegiatan penyuluhan yang dilakukan berupa pemaparan materi dan pre-test serta post-test pemahaman mengenai penyakit infeksi kulit Peserta kegiatan ini adalah masyarakat posyandu lestari 06 Dusun Saungluhur Desa Limbangan. Hasil test sebelum pemaparan materi memiliki nilai rata-rata 75.45 sedangkan setelah pemaparan materi menjadi 96.82. Terdapat perbedaan yang signifikan pengetahuan masyarakat posyanda antara sebelum dan sesudah kegiatan penyuluhan. Penyuluhan menganai pemberian penyakit infeksi kulit memberikan peningkatan pengetahuan masyarakat setempat. Kata Kunci: Penyakit, Kulit, Kesehatan, Penyuluhan  ABSTRACT Skin infections are skin diseases caused by microorganisms such as viruses, fungi, bacteria, and parasites. The skin is a protector of several organs in the body and parts of the body that are quite sensitive to several diseases. Counseling was carried out to increase the knowledge and awareness of the community to maintain cleanliness and the surrounding environment as well as treatment for skin infections. Implementation of counseling activities carried out in the form of presentation of material and an understanding test about skin infections. The test results before the presentation of the material had an average value of 75.45 while after the presentation of the material it became 96.82. There was a significant difference in the community's knowledge between before and after the extension activities. Education regarding the treatment of skin infections provides increased knowledge of the local community. Keywords: Disease, Skin, Health, Counseling
Kewaspadaan Dini Masyarakat melalui Pemanfaatan Support System Penanggulangan Gagal Ginjal Kronis
Authors: Akbar Ali , Nurpratiwi Nurpratiwi , Amaludin Mimi , Safitri Dewin , Arisandi Defa , Hidayat Uti Rusdian , Alfikrie Fauzan , Hatmalyakin Debby
Published: May 2024

ABSTRAK Gagal ginjal kronik salah satu dari penyakit tidak menular yang jumlah penderitanya terus mengalami peningkatan. Untuk itu diperlukannya upaya kewaspadaan dini terhadap penyakit GKK salah satunya dengan pemanfaatan support system. Berbagai macam support system yang dapat dimanfaatkan adalah fasilitas kesehatan terdekat serta dukungan dari keluarga. Tujuan: Kegiatan ini bertujuan untuk meningkatkan pengetahuan tentang kewaspadaan dini masyarakat melalui pemanfaatan support system penanggulangan GGK. Metode: metode yang digunakan dalam kegiatan PKM ini adalah pemberian edukasi. Hasil: sebelum diberikan edukasi pengetahuan tentang kewaspadaan dini melalui pemanfaatan support system penanggulangan GGK sebagian besar peserta memiliki pengetahuan dengan kategori rendah yaitu 46,67%, ketegori sedang 40% dan kategori tinggi 13,33%. Kemudian setelah diberikan edukasi diperoleh pengetahuan masyarakat pada kategori tinggi 73,3%. Kesimpulan: Pemberian edukasi yang diberikan dapat meningkatkan pengetahuan masyarakat tentang kewaspadaan dini melalui pemanfaatan support system penanggulangan GGK. Kata Kunci: GGK, Kewaspadaan Dini, Support System ABSTRACT Chronic kidney failure is a non-communicable disease whose number of sufferers continues to increase. For this reason, early awareness efforts for GKK disease are needed, one of which is the use of a support system. Various types of support systems that can be utilized are the nearest health facilities and support from family. Purpose: This activity aims to increase knowledge about early community awareness through the use of a CKD prevention support system. Method: The method used in this PKM activity is providing education. Results: before being given knowledge education about early awareness through the use of a CKD management support system, most participants had knowledge in the low category, namely 46.67%, 40% in the medium category and 13.33% in the high category. Then, after being given education, public knowledge was found to be in the high category at 73.3%. Conclusion: The education provided can increase public knowledge about early awareness through the use of a support system for dealing with CKD. Keywords: Ckd, Early Awareness, Support System
Edukasi Kesehatan Jiwa Lansia di Panti Sosialtresna Werdha (PSTW) Jiwa Baru Garut
Authors: Hendrawati Hendrawati , Amira Iceu , Rosidin Udin
Published: May 2024

ABSTRAK Proses penuaan merupakan proses yang tidak dapat dihindari. Pada hakikatnya, proses penuaan akan menyebabkan adanya  perubahan-perubahan pada lansia, yaitu penurunan fungsi tubuh yang terjadi secara fisiologis sehingga pada lansia lebih berpotensi terjadi permasalahan kesehatan, baik fisik maupun mental . Keadaan itu cenderung berpotensi menimbulkan masalah kesehatan secara umum maupun kesehatan jiwa secara khusus pada lansia. Kegiatan ini bertujuan untuk membantu meningkatkan  pengetahuan PSTW Jiwa Baru dan para lansia yang tinggal di Panti Sosial Tresna Werdha Jiwa Baru Garut (PSTW) tentang kesehatan jiwa. Metode yang dipergunakan dalam kegiatan ini adalah penyuluhan dengan tatap muka. Hasil kegiatannya adalah ada peningkatan yaitu 40,3 point . Kesimpulan Adanya peningkatan pengetahuan  pada petugas dan para lansia tentang kesehatan jiwa lansia , sehingga diharapkan ,para lansia mempunyai jiwa yang sehat dan memjalani hidup dengan aman dan nyaman. Kata Kunci: Kesehatan Jiwa Lansia,  Lansia, Panti Werdha  ABSTRACT The aging process is a process that cannot be avoided. In essence, the aging process will cause changes in the elderly, namely a decrease in body function that occurs physiologically so that the elderly have more potential for health problems, both physical and mental. This situation tends to have the potential to cause health problems in general and mental health in particular in the elderly. This activity aims to help increase the knowledge of PSTW Jiwa Baru and the elderly who live at the Tresna Nursing Home Jiwa Baru Garut (PSTW) about mental health. The method used in this activity is face-to-face counseling. The result of the activity was an increase of 40.3 points. Conclusion There is an increase in knowledge among officers and the elderly about the mental health of the elderly, so that it is hoped that the elderly will have a healthy soul and live their lives safely and comfortably. Keywords: Mental Health of The Elderly, Seniors, Nursing
PEMBERDAYAAN MASYARAKAT DALAM PENINGKATAN KESEHATAN MELALUI SOSIALISASI GERMAS DAN PELATIHAN KADER POSYANDU PRIMA DI KAMPUNG LIMAN BENAWI KABUPATEN LAMPUNG TENGAH
Authors: Rosmadewi Rosmadewi , Hartati Ani , Arianto Arianto , Gultom Tati Baina
Published: May 2024

Abstrak: Kampung Liman Benawi merupakan salah satu dari 14 kampung yang berada di wilayah Kecamatan Trimurjo Kabupaten Lampung Tengah. Kampung Liman Benawi berdiri pada tahun 1935 oleh pemerintah kolonial Belanda dimana seluruh penduduknya berasal dari pulau jawa sebanyak 250 kepala keluarga yang dibagi menjadi 6 (enam) bedeng antara lain: Bedeng 6 polos selatan, bedeng 6 polos utara, bedeng 6b, bedeng 6c, bedeng Girirejo/Poncowati dan bedeng 6d.Salah satu misi dari Kampung Liman Benawi yaitu meningkatnya tingkat kesehatan masyarakat dalam bentuk meningkatnya kesadaran masyarakat akan kesehatan. Berdasarkan analisa situasi di Kampung Liman Benawi terdapat permasalahan antara lain kesadaran masyarakat kurang tentang Gerakan Masyarakat untuk Berperilaku Hidup Bersih dan Sehat, kurang  optimalnya peranan kader dalam peningkatan kesehatan di masyarakat, pengetahuan yang kurang tentang tanaman obat keluarga dan kebersihan lingkungan yang kurang.Oleh karenanya, tim pengabdi Poltekkes Kemenkes Tanjungkarang melakukan kegiatan pengabdian kepada masyarakat berupa Penyuluhan Kesehatan tentang Germas dan PHBS, Pelatihan Kader Posyandu tentang Posyandu Prima dan Penanaman Obat Keluarga dan bergotong royong membersihkan lingkungan. Berkaitan dengan kegiatan pengabdian masyarakat, masyarakat cukup antusias dalam mengikuti kegiatan pengabmas yang sudah disepakati dengan pamong dan masyarakat. Sebagian besar masyarakat yang diundang untuk mengikuti kegiatan pengabdian masyarakat di kampung Liman Benawi pada hadir. Disarankan, perangkat kampung dan masyarakat memprogramkan kegiatan dalam rangka peningkatan kesehatan masyarakatnya berupa mengoptimalkan peran kader kesehatan, mengadakan kegiatan olah raga bersama setiap satu minggu sekali dan menjadwalkan kegiatan gotong royong serta memanfaatkan tanaman obat keluarga dalam rangka penanganan awal masalah kesehatan. Kata kunci: Germas, PHBS, Pelatihan Kader, Tanaman Obat Keluarga, Kebersihan Lingkungan
SOSIALISASI PENGEMBANGAN WEBSITE MENTAL HEALTH PADA WANITA USIA SUBUR
Authors: Dale Dewinny Septalia , Sudettyara Echy , Tasya Puja Islami , Yena Indah Rahma
Published: May 2024

Kegiatan ini mengevaluasi sejauh mana situs web ini memenuhi kebutuhan pengguna dengan fokus pada kredibilitas informasi, aksesibilitas, dan dukungan komunitas. Dengan mengintegrasikan data ilmiah terkini dan pengalaman individu, situs-situs ini berpotensi memainkan peran kunci dalam memberdayakan wanita untuk mengelola dan meningkatkan kesehatan kesuburan mereka secara holistik.Kesehatan mental pada wanita usia subur memiliki dampak signifikan terhadap kesejahteraan umum dan proses kehidupan sehari-hari. Fokus utama adalah pengembangan pendekatan holistik, termasuk pemberdayaan melalui informasi dan dukungan social. Penekanan pada pencegahan dan pemahaman mendalam terhadap tantangan kesehatan mental pada wanita usia subur menjadi landasan untuk mengembangkan upaya mendukung yang efektif.Platform kesehatan wanita subur di web telah menjadi sumber informasi yang vital dalam menyediakan panduan, saran, dan pengetahuan terkini terkait kesuburan Pengembangan website kesehatan mental untuk wanita usia subur bertujuan meningkatkan pemahaman dan pemberdayaan terhadap aspek-aspek kesejahteraan mental. Website ini menyediakan informasi terkini seputar manajemen stres, dukungan psikologis, dan kesehatan emosional selama fase penting kehidupan ini. Dengan fokus pada interaktivitas dan aksesibilitas, diharapkan dapat menciptakan ruang virtual yang aman dan mendukung bagi wanita usia subur.
PROGRAM KENALI DAN CEGAH STUNTING PADA BALITA SEJAK DINI SEBAGAI UPAYA PEMBANGUNAN LOKAL DI DESA CIKERUH, KECAMATAN JATINANGOR
Authors: Susanti Ari Indra , Rizky Muhammad , Santoso Ragil Adi , Mahandry Silmy Putri , Hazizah Wahdah , Gathari Yuan Veriontina
Published: May 2024

Pendahuluan: Pembangunan lokal merupakan salah satu upaya peningkatan dan pengembangan yang dilakukan oleh Pemerintah dengan melibatkan partisipasi masyarakat dalam berbagai aspek kehidupan, salah satunya adalah aspek kesehatan. Saat ini, Stunting merupakan salah satu masalah dalam aspek kesehatan, yaitu  kurangnya asupan gizi pada balita dalam kurun waktu 1000 hari pertama kehidupan yang mengakibatkan terhambatnya pertumbuhan tinggi dan berat badan anak. Selain itu, disebabkan kurangnya pengetahuan masyarakat terutama ibu hamil dan ibu yang memiliki balita terkait stunting dan bagaimana pencegahannya. Tujuan: Kegiatan pemberdayaan masyarakat ini bertujuan untuk memberikan pengetahuan tentang stunting dan upaya pencegahannya kepada ibu rumah tangga dan kader posyandu di Desa Cikeruh. Metode Penelitian: Metode yang digunakan dalam kegiatan ini dengan memberikan penyuluhan dan melibatkan partisipasi masyarakat. Kegiatan ini dibagi menjadi tiga tahap, yaitu persiapan, pelaksanaan, dan evaluasi kegiatan. Hasil: Hasil dari kegiatan pemberdayaan masyarakat ini terdapat sebagian kecil masyarakat masih kurang paham terkait faktor apa saja yang mengakibatkan stunting (16,67%). Kesimpulan: Dengan adanya kegiatan pemberdayaan masyarakat di Desa Cikeruh ini diharapkan mampu meningkatkan pengetahuan masyarakat terkait stunting dan juga pencegahannya.
Pengaruh Media Video Pernikahan Usia Dini Terhadap Tingkat Pengetahuan Remaja Putri
Authors: Dianna Dianna , Fitriani Henny , Hidayati Nur Kurnia
Published: May 2024

ABSTRACT Marriage that takes place in adolescence will generally cause problems both physiologically, psychologically and socio-economically. The impact of marriage at a young age is more evident in adolescent girls than in adolescent boys. Video media increases recall from 14% to 38%. So that it can increase knowledge. Knowing the Effect of Video Media on Early Marriage on the Knowledge of Adolescent Girls in the Tebas Health Center Working Area. Using the Quasi Experiment method, pre & post test approach without control group design. The sample of adolescent girls in Tebas Sungai Village, Tebas Health Center Working Area was 89 respondents with proportionate stratified random sampling technique. Wilcoxon statistical test. There is an effect of Video Media on Early Marriage on the Knowledge of Adolescent Girls in the Tebas Health Center Working Area with a p value of 0.000 <0.05. There is an effect of Video Media on Early Marriage on the Knowledge of Adolescent Girls in the Working Area of Puskesmas Tebas. Keywords: Knowledge, Video Media, Early Marriage  ABSTRAK Pernikahan yang terjadi pada usia remaja pada umumnya  menimbulkan permasalahan fisiologis, psikologis, dan sosial ekonomi.  Dampak pernikahan di usia muda lebih terasa pada remaja perempuan dibandingkan remaja laki-laki. Media Video meningkatkan ingatan dari 14% menjadi 38%. Sehingga dapat meningkatkan pengetahuan. Mengetahui Pengaruh Media Video Pernikahan Usia Dini Terhadap Tingkat Pengetahuan Remaja Putri Di Wilayah Kerja Puskesmas Tebas. menggunakan metode Quasi Experiment, pendekatan pre & post test without control group design. Sampel remaja putri di Desa Tebas Sungai Wilayah Kerja Puskesmas Tebas sebanyak 89 responden dengan tekhnik proportionate Stratified Random sampling. Uji statistik Wilcoxon. Terdapat pengaruh Media Video tentang Pernikahan Usia Dini terhadap Pengetahuan Remaja Putri di Wilayah Kerja Puskesmas Tebas dengan nilai p value 0,000 < 0,05. Terdapat pengaruh Media Video tentang Pernikahan Usia Dini terhadap Pengetahuan Remaja Putri di Wilayah Kerja Puskesmas Tebas. Kata Kunci: Pengetahuan, Media Video, Pernikahan Usia Dini
Epidemiologi HIV di Kota Medan Tahun 2021-2023
Authors: Tanjung Hazira Yulistia , Ismah Zata , Susanti Nofi
Published: May 2024

ABSTRACT  The importance of descriptive epidemiology based on people, place and time in HIV sufferers is known, in order to improve case finding and provide prevention and control programs to groups at risk. The city of Medan is the largest contributor to HIV cases in North Sumatra. RSU Haji Medan, is an HIV Referral Hospital, and a free ARV provider that can be an HIV representative in Medan City. To provide descriptive epidemiology and a map of the distribution of HIV sufferers in Medan City in 2021-2023. Quantitative type is descriptive using a cross-sectional design using medical record data. The sampling used was Exhaustive Sampling with a total of 121 samples. All data were analyzed using univariate analysis techniques, data on the sub-district where the patient lived was processed using QGIS 3.34.3 to see the distribution of residences of positive patients. The results showed that PLHIV had the most age characteristics, namely age 25-49 years (68.6%), male gender (75.2%), high school education (39.7%), not working (39.7%), and married (55.6%). Most people suffering from IO TB were men (60.0%), working (53.3%), and aged 25-49 years (73.3%), as well as hypertension. Most HIV cases are adults, male, have a high school education, are married, and work. Likewise, PLHIV who suffer from TB and hypertension are mostly adults, male and working. Medan Tembung District has the highest HIV cases in Medan City. Keywords: Descriptive Epidemiology, HIV, Medan City  ABSTRAK Pentingnya Epidemiologi Deskriptif berdasarkan orang, tempat, dan waktu pada penderita HIV diketahui, agar dapat meningkatkan penemuan kasus dan pemberian program pencegahan dan pengendalian kepada kelompok yang berisiko. Kota Medan penyumbang terbesar kasus HIV di Sumatera Utara. RSU Haji Medan, merupakan RS Rujukan HIV, dan penyedia ARV gratis yang dapat menjadi representatif HIV di Kota Medan. Untuk menggambarkan secara epidemiologi deskriptif dan peta sebaran penderita HIV di Kota Medan tahun 2021-2023. Jenis Kuantitatif bersifat deskriptif menggunakan desain cross sectional melalui data rekam medik. Pengambilan sampel yang digunakan yaitu Exhaustive Sampling dengan total 121 sampel. Seluruh data dianalisis dengan teknik analisis univariat, data kecamatan tempat tinggal ODHIV diolah menggunakan QGIS 3.34.3 untuk melihat sebaran tempat tinggal ODHIV. Didapatkan hasil ODHIV memiliki karakteristik usia terbanyak yaitu umur 25-49 tahun (68,6%), jenis kelamin laki-laki (75,2%), pendidikan SMA (39,7%), tidak bekerja (39,7%), dan sudah menikah (55,6%). Menderita IO TB paling banyak adalah laki-laki (60,0%), bekerja (53,3%), dan umur 25-49 tahun (73,3%), begitupun dengan Hipertensi.  Kasus HIV paling banyak adalah orang dewasa, berjenis kelamin laki-laki, berpendidikan SMA, sudah menikah, serta bekerja. Begitupun ODHIV yang menderita TB dan Hipertensi paling banyak orang dewasa, berjenis kelamin laki-laki, dan bekerja. Kecamatan Medan Tembung memiliki kasus HIV tertinggi di Kota Medan. Kata Kunci: Epidemiologi Deskriptif, HIV, Kota Medan
Pengaruh Video Edukasi Cara Pembuatan MP ASI dengan Tingkat Pengetahuan, Sikap dan Perilaku Ibu Terhadap Keberhasilan Pemberian MP ASI Pada Bayi Usia 6 Bulan di PMB Indah Dwi Susanti A.Md.Keb
Authors: Arum Etis Fatmala , Mulyana Dede Sri
Published: May 2024

ABSTRACT Complementary Food for Breast Milk (MP-ASI) is food or drink that contains nutrients given to infants/children to meet their nutritional needs. MP-ASI is given from 6 months to 24 months of age. Objective of the study to find out the effect of educational videos on how to make MP-ASI with the level of knowledge, attitudes and behavior of mothers on the success of giving MP-ASI to babies aged 6 months at PMB Indah Dwi Susanti, A.Md.Keb. The study used quasi esperimental with purposive sampling with a sample of 30 people. Data techniques are included in uivariate analysis using frequency distribution and bivariate analysis. The results of this study indicate that there is an influence of educational videos on how to make MP-ASI with the success of giving MP-ASI with a knowledge value of p-value 0.002 <0.05, attitude with a p-value of 0.001 <0.05, and behavior p-value 0.001 < 0.05. There is a significant influence on educational videos on how to make MP-ASI on the success of giving MP-ASI with the level of knowledge, attitudes, and behavior so that you get success in giving MP-ASI. It is hoped that the educational video will be a reference for the success of making and how to give MP ASI to babies aged 6 months at PMB Dwi Indah Susanti am.Ked. Keywords: Video, Knowledde, Attitude, Behaviour  ABSTRAK Makanan Pendamping ASI (MP-ASI) adalah makanan atau minuman yang mengandung gizi diberikan kepada bayi/anak untuk memenuhi kebutuhan gizinya. MP-ASI diberikan mulai umur 6 bulan sampai 24 bulan. Penelitia ini bertujuan untuk mengetahui Pengaruh Video Edukasi Cara Pembuatan Mp Asi Dengan Tingkat Pengetahuan, Sikap Dan Perilaku Ibu Terhadap Keberhasilan Pemberian Mp Asi Pada Bayi Usia 6 Bulan Di PMB Indah Dwi Susanti, A.Md.Keb. Penelitian ini menggunakan quasi esperimental dengan purposive sampling dengan sample 30 orang. Teknik data termasuk dalam analisis uivariat menggunakan distribusi frekuensi dan analisis bivariat. Hasil dari penelitian ini menunjukkan bahwa didapat adanya pengaruh video edukasi cara pembuatan MP ASI dengan keberhasilan pemberian MP ASI dengan nilai pengetahuan p-value 0,002 < 0,05, sikap dengan nilai p-value 0,001 < 0,05, dan perilaku p-value 0,001 < 0,05. Terdapat pengaruh yang signifikan video edukasi cara pembuatan MP ASI dengan keberhasilan pemberian MP ASI dengan tingkat pengetahuan, sikap, dan perilaku sehingga mendapatkan keberhasilan dalam pemberian MP ASI. Kata Kunci: Video, Pengetahuan, Sikap, Perilaku
Analysis of Health Problems as A Service Planning For the Control of Tuberculosis Disease in Magetan District, East Java
Authors: W Yulastari , S Martini , Y Purnomo
Published: May 2024

ABSTRACT This research is a study to determine what health problems or diseases need to be prioritized in health programs. The aim of the study was to determine the priority of public health problems in Magetan District. This study was an observational descriptive study conducted during January-February 2022. Prioritization of problems using the Basic Priority Rating System and PEARL methods then identifying the causes of problems using path analysis diagrams.  The determining the priority of the problem obtained that tuberculosis is the top priority. Identification of tuberculosis problems through path analysis diagrams showed that early detection activities in special places were low, screening of at-risk groups was not optimal, recording and reporting in hospitals and independent practitioners were low and suspects did not submit sputum back were the causes of low tuberculosis discovery. The results of the pathway analysis diagram are used as prevention planning such as optimizing health human resources, increasing community participation, multisectoral in TB elimination, improving the quality and quantity as well as equitable distribution of health resources, optimizing officers related to SITB reporting, forming coordination teams in each RT in contact investigation, increasing community knowledge with health promotion activities through counseling integrated with other programs. Keywords: Health Analysis, Tuberculosis, Magetan District
Orthopedic Hip Injuries Encountered in the Primary Care Setting
Authors: Berg Jeffrey , Luksch John , Fusco Catherine , Akel Wageha
Published: May 2024

Hip pain and disorders are commonly seen in adults and children in the primary care setting. Primary care physicians can manage many of these disorders through physical examinations and basic radiographs, but some may pose a challenge requiring advanced imaging and specialist intervention. This article will review 12 common hip injuries encountered in primary care,  when conservative management is feasible, and when a specialist referral is necessary.
The evolving landscape of tissue‐agnostic therapies in precision oncology
Authors: Subbiah Vivek , Gouda Mohamed A. , Ryll Bettina , Burris Howard A. , Kurzrock Razelle
Published: May 2024

Tumor‐agnostic therapies represent a paradigm shift in oncology by altering the traditional means of characterizing tumors based on their origin or location. Instead, they zero in on specific genetic anomalies responsible for fueling malignant growth. The watershed moment for tumor‐agnostic therapies arrived in 2017, with the US Food and Drug Administration's historic approval of pembrolizumab, an immune checkpoint inhibitor. This milestone marked the marriage of genomics and immunology fields, as an immunotherapeutic agent gained approval based on genomic biomarkers, specifically, microsatellite instability‐high or mismatch repair deficiency (dMMR). Subsequently, the approval of NTRK inhibitors, designed to combat NTRK gene fusions prevalent in various tumor types, including pediatric cancers and adult solid tumors, further underscored the potential of tumor‐agnostic therapies. The US Food and Drug Administration approvals of targeted therapies (BRAF V600E, RET fusion), immunotherapies (tumor mutational burden ≥10 mutations per megabase, dMMR) and an antibody‐drug conjugate (Her2‐positive–immunohistochemistry 3+ expression) with pan‐cancer efficacy have continued, offering newfound hope to patients grappling with advanced solid tumors that harbor particular biomarkers. In this comprehensive review, the authors delve into the expansive landscape of tissue‐agnostic targets and drugs, shedding light on the rationale underpinning this approach, the hurdles it faces, presently approved therapies, voices from the patient advocacy perspective, and the tantalizing prospects on the horizon. This is a welcome advance in oncology that transcends the boundaries of histology and location to provide personalized options.
The glutamate/aspartate transporter EAAT1 is crucial for T-cell acute lymphoblastic leukemia proliferation and survival
Authors: Stanulović Vesna S. , Al Omair Shorog , Reed Michelle A.C. , Roberts Jennie , Potluri Sandeep , Fulton-Ward Taylor , Gudgeon Nancy , Bishop Emma L. , Roels Juliette , Perry Tracey A. , Sarkar Sovan , Pratt Guy , Taghon Tom , Dimeloe Sarah , Günther Ulrich L. , Ludwig Christian , Hoogenkamp Maarten
Published: May 2024

T-cell acute lymphoblastic leukemia (T-ALL) is a cancer of the immune system. Approximately 20% of paediatric and 50% of adult T-ALL patients have refractory disease or relapse and die from the disease. To improve patient outcome new therapeutics are needed. With the aim to identify new therapeutic targets, we combined the analysis of T-ALL gene expression and metabolism to identify the metabolic adaptations that T-ALL cells exhibit. We found that glutamine uptake is essential for T-ALL proliferation. Isotope tracing experiments showed that glutamine fuels aspartate synthesis through the TCA cycle and that glutamine and glutamine-derived aspartate together supply three nitrogen atoms in purines and all but one atom in pyrimidine rings. We show that the glutamate-aspartate transporter EAAT1 (SLC1A3), which is normally expressed in the central nervous system, is crucial for glutamine conversion to aspartate and nucleotides and that T-ALL cell proliferation depends on EAAT1 function. Through this work, we identify EAAT1 as a novel therapeutic target for T-ALL treatment.
PLANNING FOR SUSTAINABLE DEVELOPMENT THROUGH THE INTEGRATION OF A NEW POLITICAL CULTURE
Authors: YEMELYANOV VOLODYMYR , ZAKHARCHYN GALYNA , HOLOLOBOV SERHII , RYBKINA SVITLANA , BEREZYNSKYI LEONID
Published: May 2024

The article represents an attempt to investigate the phenomenon of political culture through the lens of sustainable development. Based on comparative approach and Political Science provisions, implementation of UN Sustainable Development Goals is considered within the integration of a new political culture. Patterns characteristic for the USA and China are employed as examples, and the broad use of ‘sustainable value’ notion is suggested. It is shown that sustainability value and political culture are integral elements of sustainable development planning and practice, which should give the synergy effect.
Recent Developments in Textile Materials Based on the Piezoelectricity Concept
Authors: Steffens Fernanda
Published: May 2024

Textile materials stand out for presenting various characteristics that allow them to be used in technological solutions in the most diverse areas. In this sense, one may emphasize the growth in studies that cover the piezoelectric technology inserted in the textile area. This study aimed to gather the main and current innovations surrounding piezoelectric textile materials to highlight the various possibilities that this theme offers. For such, a search was carried out with keywords that relate piezoelectricity to textile materials, presenting 132.409 scientific papers published in the last five years. Lastly, this bibliographic review contributed positively to a view of opportunities inserted in the large textile area. Moreover, it was possible to observe some innovations and the ascension of the theme in terms of new developments.
Development of Knitwear with Vasomotor-Regulated Heating Function
Authors: Bauer Boris
Published: May 2024

The aim was to develop heated knitwear that increases heat power when the skin temperature drops and reduces heat power when the skin temperature rises, thus regulating the thermal insulation as required. The physiological term for the variability of human skin temperatures is vasomotor activity. Therefore, the term vasomotor- regulated function is used for heated knitwear that electronically regulate the heating power on the basis of skin temperature measurements. Vasomotor-regulated knitwear require the development of sensing, heat and control electronics and the integration of electronic components into knitted structures. The yarns and knitted structures developed achieve Technical Readiness Level 5 and are validated on a calorimeter that simulates human heat generation and emission.
Montblanc’s Entrepreneurship from Pens to Watches and Social Contribution through the Act of “Writing”
Authors: NAGASAWA Shin’ya
Published: May 2024

The purpose of this study is to analyze the branding of Montblanc, which is interesting in terms of brand, through its entrepreneurial spirit and social contribution. Specifically, we will focus on Montblanc’s entrepreneurial spirit, from writing instruments to watches and social contribution projects through the art of “writing.” Montblanc’s involvement in branding emphasizes the four major brand components (management resources) of history, place, people, and technology. We have provided spirited discussions on the four components and our perspectives.
Structure-Winding Components Made of Paper Yarn for Construction Applications
Authors: Haigis Kathrin
Published: May 2024

Structure-winding technology makes it possible to produce structural components economically. By using paper yarns, recyclable, sustainable components can be produced for building applications, which, for example, can also be used as wall systems to enable a new and flexible use of living space. The modules are manufactured in a dry structure winding process. Subsequent consolidation can be carried out using various techniques, depending on the application.
Aporte de nuevos emprendimientos al desarrollo de mercados locales y generación de empleo
Authors: Fernández María Victoria , López Silvia Mabel , Lavayén Mariana Gauna , Ramírez María Celeste , Luna Juan Pablo
Published: May 2024

La discusión sobre las contribuciones económicas y socio-culturales que la creación de empresas brinda al desarrollo y enriquecimiento de los mercados locales es vasta. La ciencia estudió aspectos referidos a la generación de empleo, la producción, la revitalización de los tejidos productivos regionales, la conformación de redes y creación de sinergias inter e intrasectoriales, la canalización de energías creativas de la población y la articulación de necesidades locales, entre otras. Este trabajo procura evaluar estos aportes para una muestra de pequeños emprendimientos de hasta siete años de vida en Esquel. Los resultados son favorables en relación con el empleo, la innovación y diversificación productiva y de menor alcance en términos de independencia de mercados externos para la provisión de insumos y del  local para la obtención de ingresos.
AAN 2024 Abstract Highlights
Authors: EMJ European Medical Journal
Published: May 2024

The following highlights spotlight selected abstracts
presented at the American Academy of Neurology (AAN)
2024 Annual Meeting. Covering a range of topics, from
cognitive decline impacting speech behavior to assisted
reproductive technologies in multiple sclerosis, read on for
this year’s most innovative new research in neurology.
Sherlock Holmes in Transit
Authors: Lauridsen Palle Schantz
Published: May 2024

The figure of Sherlock Holmes and the myriad border-crossing transmedia texts about him are at the centre of this chapter.
It investigates the entanglement of Danish-German film culture through the example of silent-era Danish and German Holmes films (those made by Viggo Larsen in Denmark may be the earliest screen adaptations anywhere), but also looks at penny dreadfuls and stage plays to describe the broader level of media culture and provide transmedia perspectives. The reception of Sherlock Holmes in Denmark was strongly affected by German adaptations and appropriations of the figure, including those by actor Ferdinand Bonn, author of a German stage version of The Hound of the Baskervilles, who also appeared in several films made by Nordisk in Denmark.
‘Die Deutsch-Nordische-Film-Union marschiert!’: the Entangled Relations between Nordisk Films Kompagni, UFA, and DNFU 1918–1928
Authors: Thorsen Isak
Published: May 2024

The chapter analyses how Nordisk Films Kompagni, the largest Danish film production company, was thoroughly enmeshed with the German market until the end of the 1920s. A major international force until 1914, the company suffered severe setbacks during and after World War I. The chapter examines Nordisk’s distribution deal with Famous Players, setting up the Danish-American Film Corporation (DAFCO) to circulate first-class Hollywood films in Germany, as well as Nordisk’s long-running ties with the big German film combine UFA. The chapter gives particular attention to Nordisk’s late-1920s German subsidiary Deutsch-Nordische Film-Union (DNFU), which produced more films than the parent company in Copenhagen; the subsidiary’s films are an exemplary instance of the ‘Film Europe’ production strategy.
A Curious Love Affair? EU–Turkey Relations
Authors: Aydın-Düzgit Senem
Published: May 2024

This chapter will provide an assessment of Turkey’s relations with the EU from its application for associate membership in 1959 to date by focusing in particular on the Cold War years and Turkey’s second application for membership in 1987; the 1990s as an era in which both sides redefined their identities and interests in the aftermath of the Cold War; the 2000s, which comprised the golden age of relations between the two sides (2001–5) as well as a period of stagnation; and the post-2016 era, characterised by mostly conflictual relations and limited transactional cooperation which lasts up to the present day. The chapter will also focus on the factors explaining the tumultuous nature of the relationship, which lie both in Turkey and in the EU as well as in the interaction between the two sides. It will conclude by discussing the current state of and the potential future scenarios for EU–Turkey relations.
Literature in Oman during the Reign of Sultan Qaboos
Authors: Michalak-Pikulska Barbara
Published: May 2024

Written cultural and literary life flourished in Oman from 1970 to 2020. While modern Omani writing is grounded in traditions of story-telling and poetry that pre-date this period, increased education, the official promotion of culture and the rise of new technologies and infrastructure has allowed Omanis to express themselves to a much wider public both within Oman and outside its borders. Omani writers grew in fame throughout the Arabic world, and the rest of the world in translation.
The Little Space Between Hal Ashby and Richard Linklater
Authors: Stone Rob
Published: May 2024

This chapter offers a comparative analysis of Linklater with Ashby, drawing parallels between their films, philosophy, filmmaking practice and positioning in relation to Hollywood studios and the independent filmmaking sector. Comparative analysis of The Last Detail (1973) and Before Sunrise (1995), which share the exact same premise of characters who have just met making connections as they move towards an inexorable deadline, reveals the filmmakers’ kindred philosophy and working practice. Pushing style and structure to pay attention to the details of human interaction prompts further comparisons, which culminates with the direct link between the filmmakers that is Linklater’s poignant rendition of Last Flag Flying (2017) as “a spiritual sequel” to The Last Detail, analysis of which suggests that connecting their filmographies creates and completes a long, unbroken list of unheeded warnings against authoritarianism and the unconsidered life.
Türkiye ve Türk Cumhuriyetlerinin Toplumsal Cinsiyet Eşitliğinin Endeksler Bağlamında Karşılaştırılması
Authors: Özsoy Dilek
Published: May 2024

Küresel düzeyde özellikle 2000'li yıllardan itibaren toplumsal cinsiyet eşitsizliğinin ortadan kaldırılmasına yönelik büyük ilerlemeler kaydedilmiş olmasına karşın bu ilerlemelerin istatistikler aracılığıyla ne aşamada olduğunun tespiti ve ülkeler arası karşılaştırmaların yapılması, ileriye dönük çalışmaların planlanması ve stratejilerin oluşturulması açısından önem taşımaktadır.
Cinsiyet eşitliği insan hakkı olmasının yanında ekonomik kalkınmanın da itici gücüdür. Nüfusun yarısını temsil eden kadınların birçok sosyo ekonomik sonuçlar açısından nüfusun diğer yarısını temsil eden erkeklerden geride kalması ve bu durumun devamına yönelik yaklaşımlar insani gelişmişlik açısından toplumun tamamını olumsuz yönde etkilemektedir. Bu bağlamda toplumsal cinsiyet eşitliğine yönelik ölçülebilir göstergeler yoluyla yapılan karşılaştırmalar bu alandaki politikaların değerlendirilmesinde ana göstergeler olarak karşımıza çıkmaktadır.
Bu çalışmada benzer sosyo-kültürel yapıya sahip Türk Cumhuriyetleri ve Türkiye’nin kadına yönelik sosyal politikalardaki gelişimlerin Birleşmiş Milletlerin toplumsal cinsiyet eşitliğine yönelik oluşturduğu uluslararası endeksler aracılığıyla irdelenmiştir. Çalışmada endekslerin kadınlara ilişkin sağlık, eğitim, ekonomik ve siyasal temsil oranlarını içeren alt boyutları ele alınmıştır. Buna göre ülkelerin ekonomik gelişimin yanında insani kalkınmayı gerçekleştirebilmeleri için nüfusun yarısını oluşturan kadınlara yönelik sağlık, eğitim, istihdam ve karar alma süreçlerinde toplumsal cinsiyet eşitliğine dayalı politikaların benimsenmesi ve uygulanması sonucunda ülkelerin insani gelişim endekslerinde sağlanan gelişmeler toplumsal cinsiyet endekslerine de yansıyabilecektir.
Afetin Toplumsal Cinsiyet Boyutu: Türkiye'nin Diyarbakır Şehrinde Depremi Yaşayan Kadınlarla İlgili Bir Örnek Olay İncelemesi
Authors: Yakıt Ak Eda , Uyurdağ Nermin
Published: May 2024

Bu çalışma, depremin kadınlar üzerindeki toplumsal, sosyoekonomik ve sağlık sonuçlarının etkilerini belirlemek amacıyla planlandı.
Çalışma Ekim-Kasım 2023 tarihlerinde 14 kadın ile kalitatif tipte gerçekleştirildi. Diyarbakır ilinde yaşayan ve depremden etkilenen; 5 hemşire, 5 deprem nedeniyle yerinden edilmiş ve 4 anne olan kadın ile çalışma tamamlandı. Çalışma verileri yarı yapılandırılmış görüşme formu ile toplandı. Görüşmeler, deşifre sonrası tematik analiz ile değerlendirildi. Çalışma için kurumsal ve bireysel etik onamlar alındı.
Kadınların yaş ortalaması 43 olup, 13’ü evli, tamamı lise ve üzeri mezun ve 11’i gelir getiren bir işte çalıştığı belirlendi. Katılımcıların %71,4’ünün evi tamamen yıkılmış ya da hasar görmüştü, %35,7’sinin ailesinden yaralanan/zarar görenler vardı ve %57,1’i sevdiği birini deprem nedeniyle kaybetmişti. Kadınlar ev içi sorumlulukları olarak, %96’sı çocukları yetiştirmenin, %78,6’sı ev yönetiminin ve %78,6’sı aile üyelerine bakım vermenin görevleri olduğunu belirtti. Kadınların barınma sorunları, ev içi rollerinin artması, eşe destek olma, ekonomik gelir kaynaklarını sürdürmesi kaygıları ve çocukların bakımı konusunda yaşadıkları endişeler en önemli görülen sorunlar arasındaydı. Deprem sonrası kadınların ev içi sorumluluklarını artırdığı, çocuk bakımında zorlandıkları ve iş yaşantısından geride kaldıkları belirlendi. Deprem sonrası çalışmak zorunda kalan hemşireler ailelerini geride bırakma ve destek olmamama durumlarını ve hastalara yardım etmede yaşadıkları tatmini de bildirdi.
Sonuç olarak, deprem sonrası kadınlar toplumsal cinsiyet rollerinde artış yaşamışlardır. Kadınların sorumluluklarındaki bu artış kırılgan olma durumlarını artırmaktadır. Bu nedenle kadınları afet zamanlarında destek olacak ve koruyacak mekanizmalarının geliştirilmesi önemlidir.
Social exclusion in service settings amongst Swedish-speaking older adults in Finland: Language incongruency or identity discrimination, or both?
Authors: Häkkinen Emilia , Nyqvist Fredrica , Nordberg Camilla , Nygård Mikael , Björklund Siv , Hemberg Jessica
Published: May 2024

Previous studies suggest that older adults from minority linguistic groups are at a higher risk of experiencing social exclusion, with service exclusion being a highly evident form. This article explores how Swedish- speaking older adults in Finland experience the availability and adequacy of services in their first language and how their experiences are linked to social exclusion. Anchored in the intersection between two dimensions of social exclusion, service exclusion and identity exclusion, this study presents findings from 14 semi-structured interviews with uni- and bilingual Swedish-speaking older adults. The results indicate that inequitable access to services and facing language discordant services can shape experiences of exclusion. The inability to receive everyday services in Swedish further fosters feelings of inferiority and identity discrimination. This study findings contribute to the social gerontologicalliterature on social exclusion and demonstrate how identity intersections with service exclusion.
Non-back-drivable clutch based self-locking mechanism of prosthetic joint to improve manipulation stability
Authors: Liu Yang , Luo Yuhui , Xiao Ting , Liang Jiejunyi
Published: May 2024

During activities of daily living (ADLs), the wrist is mainly engaged in positioning and directing the hand. Researches have demonstrated that restoring wrist mobility can significantly enhance the manipulation ability, reduce body distortion caused by motion compensation, and improve the quality of life for amputees. However, most daily activities, particularly the delicate ones, place high demands on the ability of wrist to maintain a certain rotation angle, also known as non-back-drivable ability, which poses a challenge to the design of prosthetic wrists. To address this issue, various solutions have been proposed, including motor holding brakes, high reduction ratio reducers, and worm gears. However, the motor holding brake only functions after a power outage and cannot continuously prevent torque from the load end. The latter two solutions may alter the transmission ratio, resulting in reduced movement speed and transmission efficiency. Therefore, how to design a miniaturized non-back-drivable mechanism without changing the transmission ratio so that the forearm rotational freedom can be locked at any position for any duration is a problem to be solved in the research of prosthetic wrist designs. This paper presents a line-contact based non-back-drivable clutch (NBDC) that does not cause changes in the transmission ratio, ensuring the motion performance of the prosthetic limb. At the same time, it does not introduce additional friction in the forward transmission process, guaranteeing the overall efficiency. Most importantly, it only allows the torque transmitting from the motor to the load, prevents the load reversely from driving back even in a power failure condition, significantly improving the stability, safety, and comfort. Detailed kinematic and static analyses of the working process has been conducted, and transient dynamics simulation has been performed to verify its effectiveness. Through experiments, it is demonstrated that the self-locking torque of the output end could reach approximately 600 Nmm, and the unlocking torque of the input end is about 80 Nmm, which can be effectively integrated in prosthetic wrist rotation joints, contributing to the performance, safety and energy saving of prosthetic joint systems.
Modeling and categorizing standardized artifacts for scheduling occupancy on building construction sites
Authors: Morin Pépin Stéphane , Francis Adel
Published: May 2024

The new trend in planning building projects involves incorporating space management on the construction site. Failing to consider the management of site operations can lead to either relaxed or congested construction sites. This is because labor, tools, equipment, and materials all require space. It is important to plan for the circulation and temporary storage of materials, including recycling, reuse, and disposal. Temporary installations and finished products also take up space and can impact traffic flow. For example, partitions can impair traffic flow, while finished flooring can restrict it. The occupation of spaces also changes as the work progresses, so it is important to monitor and accommodate these changes. Therefore, space management needs to be coordinated throughout the construction phase. Traditional planning methods do not consider the analysis of critical spaces or their evolution over time. As a result, they produce schedules that do not reflect the reality of the construction site. Dynamic space-time planning means modelling the operational flow in different sectors of the construction site to optimize the construction process. Efficient space occupation allows for more effective utilization of available resources. This paper aims to analyze the spatial requirements of various construction operations and develop standardized artifacts that integrate spatial information into the schedule. To achieve this objective, the methodology aims to: (i) Conduct site surveys to collect data and analyze construction operations and their spatial needs; (ii) Define the necessary parameters for determining the occupancy rate (OR); (iii) Develop the needed artifacts for representing the static models based on the survey results and the developed occupancy parameters to visually depict and compute various types of occupancy and operations; (iv) Conduct workshops with the professionals in the construction industry. The participants were asked to provide feedback on whether the artifacts effectively captured the various aspects of construction work, such as equipment, tools, materials, and safety protocols. The aim is to validate that the artifacts as reliable representations of real-life construction scenarios. The feedback and input provided by the professionals helped to ensure that the artifacts were accurate, informative, and valuable for training purposes in the construction industry.
Chlamydomonas as a model system to study cilia and flagella using genetics, biochemistry, and microscopy
Authors: Marshall Wallace F.
Published: May 2024

The unicellular green alga, Chlamydomonas reinhardtii, has played a central role in discovering much of what is currently known about the composition, assembly, and function of cilia and flagella. Chlamydomonas combines excellent genetics, such as the ability to grow cells as haploids or diploids and to perform tetrad analysis, with an unparalleled ability to detach and isolate flagella in a single step without cell lysis. The combination of genetics and biochemistry that is possible in Chlamydomonas has allowed many of the key components of the cilium to be identified by looking for proteins that are missing in a defined mutant. Few if any other model organisms allow such a seamless combination of genetic and biochemical approaches. Other major advantages of Chlamydomonas compared to other systems include the ability to induce flagella to regenerate in a highly synchronous manner, allowing the kinetics of flagellar growth to be measured, and the ability of Chlamydomonas flagella to adhere to glass coverslips allowing Intraflagellar Transport to be easily imaged inside the flagella of living cells, with quantitative precision and single-molecule resolution. These advantages continue to work in favor of Chlamydomonas as a model system going forward, and are now augmented by extensive genomic resources, a knockout strain collection, and efficient CRISPR gene editing. While Chlamydomonas has obvious limitations for studying ciliary functions related to animal development or organ physiology, when it comes to studying the fundamental biology of cilia and flagella, Chlamydomonas is simply unmatched in terms of speed, efficiency, cost, and the variety of approaches that can be brought to bear on a question.