bluuebunny/crossref_metadata_2025 huggingface dataset:
Digitalverantwortung als Chance
Authors: Esselmann Frank , Brink Alexander
Published: September 2020

Corporate Digital Responsibility stellt eine neue Herausforderung für Unternehmen dar. Wie kann durch verantwortungsvollen Umgang mit Daten das Vertrauen der Kund/innen gewonnen werden? Ein neues Instrument unterstützt Unternehmen bei diesem offenen Dialog mit Verbraucher/innen über Unternehmenswerte und Unternehmensziele.
Wie der Klimawandel sich auf die nachhaltige Waldbewirtschaftung auswirkt
Authors: Remler Sophia
Published: September 2020

Weltweit leiden die Wälder unter den Auswirkungen eines sich verändernden Klimas und werden sich selbst drastisch verändern.Die Forstwirtschaft steht vor einem großen Umbruch. Wie kann diese Transformation genutzt werden, um zusätzliche Potenziale für den Klimaschutz zu erschließen?
Coaching von Vereinen als Instrument des Nachhaltigkeitsmanagements
Authors: Ahrend Klaus-Michael , Funk Katja
Published: September 2020

Für Unternehmen, die aktiv zum Public Value beitragen möchten, ist neben der rein monetären Unterstützung durch Spenden und Sponsoring der lokalen Vereine auch das Coachen der Vereinsverantwortlichen eine sinnvolle Corporate Social Responsibility Maßnahme. Im Coaching können die Geschäftsmodelle und die damit verbundene strategische Ausrichtung der Vereine analysiert und optimiert werden.
THE CURRENT STATE AND ISSUES OF PREPARATION OF AN ATHLETIC RESERVE (BASED ON THE SOCIOLOGICAL RESEARCH)
Authors: Zotova F , Alhusni A , Valiullin R , Martynova V , Chemov V , Cherkashin V , Shubin M
Published: September 2020

Aim. The article deals with the analysis of the current state and issues of training sports reserve in track and field. Materials and methods. A questionnaire consisting of 12 questions and 57 subquestions of open-ended, close-ended and multiple choice types was developed. The questionnaire-based survey was carried out among Russian and Chinese coaches (n = 161) aged 20–72 years including Honored coaches of the Russian Federation (n = 7) and elite coaches (n = 38). Results. The questionnaire-based survey for coaches demonstrated that they worried about: declining popularity of track-and-field compared to other sports; early specialization and related risks; low qualification of coaches working with children and teenagers. Respondents pay special attention to negative consequences of early specialization such as early retirement from sport, loss of promising athletes; short career in elite sports; growing number of sports-related injuries in young athletes. According to coaches, the main factors contributing to early specialization are the following: a) specialized training, which results in a rapid growth of sport results; b) achievements in sports are so high that a coach has to search for sports reserve among children. According to the respondents, young athletes should participate in competitions to learn how to overcome themselves and accumulate competitive experience. The majority of respondents think that integrated training in track-and-field is one of the important factors of successful career. Conclusion. A social survey of coaches has revealed peculiarities and issues typical for training sports reserve in track-and-field, which have to be considered and resolved.
The Economic Effects of COVID-19 on the Producers of Ethanol, Corn, Gasoline, and Oil
Authors: Schmitz Andrew , Moss Charles B. , Schmitz Troy G.
Published: September 2020

The COVID-19 crisis created large economic losses for corn, ethanol, gasoline, and oil producers and refineries both in the United States and worldwide. We extend the theory used by Schmitz, A., C. B. Moss, and T. G. Schmitz. 2007. “Ethanol: No Free Lunch.” Journal of Agricultural & Food Industrial Organization 5 (2): 1–28 as a basis for empirical estimation of the effect of COVID-19. We estimate, within a welfare economic cost-benefit framework that, at a minimum, the producer cost in the United States for these four sectors totals $176.8 billion for 2020. For U.S. oil producers alone, the cost was $151 billion. When world oil is added, the costs are much higher, at $1055.8 billion. The total oil producer cost is $1.03 trillion, which is roughly 40 times the effect on U.S. corn, ethanol, and gasoline producers, and refineries. If the assumed unemployment effects from COVID-19 are taken into account, the total effect, including both producers and unemployed workers, is $212.2 billion, bringing the world total to $1266.9 billion.
Neuropsychiatric symptoms, quality of life and caregivers’ burden in dementia
Authors: Majer Réka , Adeyi Olar , Bagoly Zsuzsa , Simon Viktória , Csiba László , Kardos László , Hortobágyi Tibor , Frecska Ede
Published: September 2020

The objective of this research is to identify the relationship between the neuropsychiatric symptoms (NPSs) of patients with major neurocognitive disorder (mNCD), their quality of life, illness intrusiveness and the caregiver’s burden. We assessed 131 patients with mNCD. Examination methods included WHO well-being index short version, illness intrusiveness rating scale, Alzheimer’s Disease Assessment Scale-Cog, Mini Mental State Examination and neuropsychiatric inventory. The results were analysed using standard statistical tests. In our sample, the prevalence of NPSs is 100%. A significant correlation (p < 0.0001) was observed with quality of life and illness intrusiveness. Additionally, a strong relationship was observed between NPSs and the caregiver’s burden (r = 0.9). The result is significantly twice as much stronger in comparison to the relationship between NPS and cognitive symptoms (r = 0.4). This is the first study in Hungary to assess the impact of NPS on the burden of relatives and quality of life. NPS had twice stronger impact on caregivers’ burden than cognitive decline. However, further studies are needed to assess the sub-syndromes in mNCD in relation to NPS.
Neuronal functions of clathrin-associated endocytic sorting adaptors – from molecules to disease
Authors: Kononenko Natalia L. , Haucke Volker
Published: September 2020

Communication in the central nervous system is based on the transmission of electrical signals at specialized junctions between nerve cells termed synapses. During chemical neurotransmission, tiny membrane spheres called synaptic vesicles that are packed with neurotransmitters elicit a postsynaptic response by fusing with the presynaptic membrane and releasing their content into the synaptic cleft. Synaptic vesicle fusion is followed by the reuptake of the membrane by endocytosis and the local reformation of functional synaptic vesicles within the presynaptic compartment to sustain further rounds of neurotransmitter release. Here, we provide an overview of the clathrin-associated endocytic adaptor proteins that help to sort and recycle synaptic vesicles during presynaptic activity. These adaptors also serve additional functions in the turnover of defective or aged synaptic components and in the retrograde axonal transport of important signaling molecules by regulating the formation or transport of autophagosomes. Endocytic adaptors thus play multiple roles in the maintenance of synaptic function. Defects in their expression or function can lead to neurodegenerative and neurological diseases.
Chemochromatische Himmelsereignisse. Aurora Borealis und ihre künstl/er\i/s\chen Schwestern
Authors: Hinterwaldner Inge
Published: September 2020

With the current renewed space race to the moon, space art, which is understood here as a variation of the Art & Technology movement, is also increasingly garnering attention. In the 1960s and 1970s, the artists Newton Harrison, Joe Davis, and Paulo Bruscky each independently pursued the goal of artificially creating a widely visible aurora. With their idea of placing floating colored light into the sky, they ventured into areas for which science could not yet offer any ready-made technologies. It was not clear whether – or how – these light phenomena could be created. The artists’ aspirations provoked considerable political resistance as well. The scale of the projects immediately revealed an ecological relevance. It was not until years later that a theoretical, new materialist framework was established that increased understanding of what these works explored.
On Two Overlooked Details in ­Leonardo da Vinci’s Adoration of the Magi
Authors: Pestilli Livio
Published: September 2020

This article focuses on two features of Leonardo’s Adoration of the Magi made more readable after its restoration: the old man behind the Virgin and the object painted in front of him. In contrast to previous interpretations, it is argued that the old man does not represent St. Joseph. Rather, it is St. Donatus, patron saint of the Canons Regular of St. Augustine who commissioned the altarpiece for their church of San Donato a Scopeto. If, as argued, the garment he wears is a chasuble, the object in front of him a wine vat and the vessel he holds a pyx, then the painting referenced both the theme of the Adoration of the Magi and the patron saint’s miracle of the mass while telescoping in a visual prolepsis the beginning and the end of the Christ Child’s redeeming mission.
In-Stent Thrombosis after Antiplatelet Therapy Conversion while Awaiting Coronary Bypass
Authors: Burke Nathan , Charlton Tawanna , Hawamdeh Hussam , Park Ki
Published: September 2020

In-stent thrombosis (IST) is a rare yet dangerous complication that may occur despite optimized coronary intervention in the cardiac catheterization laboratory. This is a case of an 81-year-old man who presented with ST-elevation myocardial infarction. Right coronary artery (RCA) occlusion was suspected. RCA angiography and percutaneous coronary intervention were performed. Complicated left coronary artery disease was subsequently discovered. Per cardiothoracic surgeon request, the patient was transitioned from ticagrelor to clopidogrel therapy in preparation for coronary artery bypass grafting. The patient experienced IST the day before surgery while receiving clopidogrel. We examine this case, which highlights the complexity of antiplatelet therapy choice and the role of genetic testing in evaluation of IST risk.
Management of endocrine immune-related adverse events of immune checkpoint inhibitors: an updated review
Authors: Stelmachowska-Banaś Maria , Czajka-Oraniec Izabella
Published: September 2020

Immune checkpoint inhibitors (ICIs) belong to a new group of anticancer drugs targeting T-cell proteins involved in the activation of immune response toward malignancies. Their introduction into clinical practice was a milestone in modern cancer treatment. However, the significant advantage of ICIs over conventional chemotherapy in terms of therapeutic efficacy is accompanied by new challenges related to specific side effects. ICI-induced immune system activation could lead to the loss of self-tolerance, presenting as autoimmune inflammation and dysfunction of various tissues and organs. Thus, the typical side effects of ICIs include immune-related adverse events (irAEs), among which endocrine irAEs, affecting numerous endocrine glands, have been commonly recognized. This review aimed to outline the current knowledge regarding ICI-induced endocrine disorders from a clinical perspective. We present updated information on the incidence and clinical development of ICI-induced endocrinopathies, including the most frequent thyroiditis and hypophysitis, the rarely observed insulin-dependent diabetes mellitus and primary adrenal insufficiency, and the recently described cases of hypoparathyroidism and lipodystrophy. Practical guidelines for monitoring, diagnosis, and treatment of ICI-related endocrine toxicities are also offered. Rising awareness of endocrine irAEs among oncologists, endocrinologists, and other health professionals caring for patients receiving ICIs could contribute to better safety and efficacy. As immunotherapy becomes widespread and approved for new types of malignancies, increased incidences of endocrine irAEs are expected in the future.
Re-visiting autoimmunity to sodium-iodide symporter and pendrin in thyroid disease
Authors: Eleftheriadou Anna-Maria , Mehl Sebastian , Renko Kostja , Kasim Rega H , Schaefer Jasmin-Annabelle , Minich Waldemar B , Schomburg Lutz
Published: September 2020

Objective

Iodide transport across thyrocytes constitutes a critical step for thyroid hormone biosynthesis, mediated mainly by the basolateral sodium-iodide-symporter (NIS (SLC5A5)) and the apical anion exchanger pendrin (PDS (SLC26A4)). Both transmembrane proteins have been described as autoantigens in thyroid disease, yet the reports on autoantibody (aAb) prevalence and diagnostic usefulness are conflicting. Reasons for the inconclusive findings may be small study groups and principle differences in the technologies used.

Design

We decided to re-evaluate this important issue by establishing novel non-radioactive tests using full-length antigens and comparable protocols, and analyzing a large cohort of thyroid patients (n = 323) and control samples (n = 400).

Methods

NIS and PDS were recombinantly expressed as fusion protein with firefly luciferase (Luc). Stably transfected HEK293 cells were used as reproducible source of the autoantigens.

Results

Recombinant NIS-Luc showed iodide transport activity, indicating successful expression and correct processing. Commercial antibodies yielded dose-dependent responses in the newly established assays. Reproducibility of assay signals from patient sera was verified with respect to linearity, stability and absence of matrix effects. Prevalence of PDS-aAb was similar in thyroid patients and controls (7.7% vs 5.0%). NIS-aAb were more prevalent in patients than controls (7.7% vs 1.8%), especially in Graves’ Disease (12.3%). Neither NIS-aAb nor PDS-aAb concentrations were related to TPO-aAb or TSH-receptor-aAb concentrations, or to serum zinc or selenium status.

Conclusions

Our data highlight a potential relevance of autoimmunity against NIS for thyroid disease, whereas an assessment of PDS-aAb in thyroid patients seems not to be of diagnostic value (yet).
Coincidencia entre agenda mediática y política en las cuentas de Twitter de los 4 candidatos con más votos para la alcaldía de Quito
Authors: Cruz Jorge
Published: September 2020

Las intervenciones de los políticos en Twitter son medios con importancia para conocer cómo se complementa el discurso. La elección de alcalde de Quito 2019 presenta una oportunidad interesante para analizar cómo se construye ese pensamiento. Esta investigación encuentra cómo los tuits pueden reflejar la relación entre la agenda política y la agenda mediática. Estas dos agendas, se cruzan -en una perspectiva multimodal- a partir de cómo los políticos crean discurso (teorías de la propiedad y prominencia de las cuestiones) y cómo los medios lo hacen.

El estudio se refiere a los cuatro primeros candidatos en las elecciones seccionales (Yunda, Maldonado, Moncayo y Montúfar). El trabajo, a partir de una revisión a los planes de trabajo y a cientos de tuits de los candidatos, genera cuantificaciones y comparaciones en las temáticas trascendentales y comunes. Los hallazgos visualizan si se modificó o no el discurso político.
Estrategias de campaña electoral centradas en las características personales del candidato
Authors: Enríquez Cruz María José
Published: September 2020

La presente nota de campaña analiza cualitativamente, los rasgos de la imagen política del candidato a la Alcaldía de Quito, Jorge Yunda Machado, y cómo se configura para mostrar un político humano y cercano con los electores. Para tal efecto se toman en cuenta las fotografías y vídeos publicados en la página web http://jorgeyunda.com.ec , así como una entrevista con la asesora de la campaña.Para este caso particular, se hace referencia a las características de la propaganda, la utilización de recursos iconográficos y el discurso que enfatiza los orígenes humildes de Yunda. La fundamentación de esta nota, se basa en los aportes de Canel (2008) referidos a la configuración de la imagen del candidato, la tipología de propaganda de D’Adamo y García Beaudoux (2011) y las definiciones de Annunziata (2011) referidas a la proximidad política, como una nueva forma de plasmar campañas electorales.
TheCellVision.org: A Database for Visualizing and Mining High-Content Cell Imaging Projects
Authors: Masinas Myra Paz David , Usaj Mojca Mattiazzi , Usaj Matej , Boone Charles , Andrews Brenda J
Published: September 2020

Advances in genome engineering and high throughput imaging technologies have enabled genome-scale screens of single cells for a variety of phenotypes, including subcellular morphology and protein localization. We constructed TheCellVision.org, a freely available and web-accessible image visualization and data browsing tool that serves as a central repository for fluorescence microscopy images and associated quantitative data produced by high-content screening experiments. Currently, TheCellVision.org hosts ∼575,590 images and associated analysis results from two published high-content screening (HCS) projects focused on the budding yeast Saccharomyces cerevisiae. TheCellVision.org allows users to access, visualize and explore fluorescence microscopy images, and to search, compare, and extract data related to subcellular compartment morphology, protein abundance, and localization. Each dataset can be queried independently or as part of a search across multiple datasets using the advanced search option. The website also hosts computational tools associated with the available datasets, which can be applied to other projects and cell systems, a feature we demonstrate using published images of mammalian cells. Providing access to HCS data through websites such as TheCelllVision.org enables new discovery and independent re-analyses of imaging data.
Maximuma posterioriThreshold Genomic Prediction Model for Ordinal Traits
Authors: Montesinos-López Abelardo , Gutierrez-Pulido Humberto , Montesinos-López Osval Antonio , Crossa José
Published: September 2020

Due to the ever-increasing data collected in genomic breeding programs, there is a need for genomic prediction models that can deal better with big data. For this reason, here we propose a Maximum a posteriori Threshold Genomic Prediction (MAPT) model for ordinal traits that is more efficient than the conventional Bayesian Threshold Genomic Prediction model for ordinal traits. The MAPT performs the predictions of the Threshold Genomic Prediction model by using the maximum a posteriori estimation of the parameters, that is, the values of the parameters that maximize the joint posterior density. We compared the prediction performance of the proposed MAPT to the conventional Bayesian Threshold Genomic Prediction model, the multinomial Ridge regression and support vector machine on 8 real data sets. We found that the proposed MAPT was competitive with regard to the multinomial and support vector machine models in terms of prediction performance, and slightly better than the conventional Bayesian Threshold Genomic Prediction model. With regard to the implementation time, we found that in general the MAPT and the support vector machine were the best, while the slowest was the multinomial Ridge regression model. However, it is important to point out that the successful implementation of the proposed MAPT model depends on the informative priors used to avoid underestimation of variance components.
Projektbewertung bei niedrigen Zinssätzen
Authors: Thießen Friedrich
Published: September 2020

Anhand von vier stilisierten Fällen werden die Bewertungsprobleme bei niedrigen positiven wie auch negativen Zinssätzen systematisiert. Dabei werden Zinssätze von +8% (herkömmlicher Kapitalmarkt) über 0% bis -5% betrachtet. Die Formel der Ewigen Rente kommt zu unplausiblen Werten und besitzt Unstetigkeitsstellen. Die Barwertmethode ist robuster. Eine Reihe von Bewertungsparametern ist mit wesentlich mehr Sorgfalt zu planen als bisher. Übliche Techniken zur Verringerung des Bewertungsaufwandes lassen sich nicht mehr einsetzen.
Die TARGET-Kontroverse
Authors: Seidl Christian
Published: September 2020

An der Kernfrage, ob Targetsalden lediglich Abgrenzungsposten eines Überweisungssystems im Rahmen der Europäischen Währungsunion, oder aber Kredit- bzw. Schuldbeziehungen zwischen souveränen Staaten eines Staatenbundes sind, hat sich jüngst eine heftige Kontroverse zwischen Martin Hellwig (erstere Position) und Hans-Werner Sinn (letztere Position) in den Perspektiven der Wirtschaftspolitik entwickelt. Darüber berichtet dieser Aufsatz, wobei dessen Autor auch den eigenen Beitrag der Einführung einer Neuen D-Mark als Parallelwährung beisteuert.
Coronavirus-Pandemie: Eine makroökonomische Analyse
Authors: Beck Hanno , Prinz Aloys
Published: September 2020

Die aktuelle Corona-Pandemie wird zu schweren makroökonomischen Verwerfungen führen. Mit welchen Folgen muss man rechnen, welche Instrumente zur Bekämpfung werden bisher genutzt oder könnten genutzt werden? Dieser Beitrag fasst die wichtigsten Fakten hierzu zusammen und analysiert die Situation und die Politikoptionen anhand zwei einfacher makroökonomischer Modelle.
Effektive Klimapolitik per Geldpolitik
Authors: Walter Johann
Published: September 2020

Der Beitrag macht aus Anlass der jüngsten Berichte des Weltklimarates Vorschläge für eine effektive Klimapolitik per „grüner“ Geldpolitik.
Boosting the extensibility potential of fibre networks: A review
Authors: Vishtal Alexey , Retulainen Elias
Published: September 2020

Production of paper-based packaging is growing at the present moment and has great future prospects. However, the development of new packaging concepts is creating a demand for an improvement in the mechanical properties of paper. Extensibility is one of these properties. Highly extensible papers have the potential to replace certain kinds of plastics used in packaging. Extensibility is also important for the sack and bag paper grades and for runnability in any converting process. This paper reviews the factors that affect the extensibility of fibres and paper, and discusses opportunities for improving the straining potential of paper and paper-like fibre networks. It is possible to classify factors that affect extensibility into three main categories: fibre structure, interfibre bonding, and structure of the fibre network. Extensibility is also affected by the straining situation and the phase state of the polymers in the cell wall. By understanding the basic phenomena related to the elongation, and by combining different methods affecting the deformability of fibre network, extensibility of paper can be raised to a higher level.
Identification and characterization of diverse xylanases from thermophilic and thermotolerant fungi
Authors: Ghatora Sonia K. , Chadha Bhupinder S. , Badhan A. K. , Saini H. S. , Bhat M. K.
Published: September 2020

Thirteen fungal isolates included in this study expressed multiple xylanase isoforms as observed by xylan zymograms of polyacrylamide gel electrophoresis (PAGE) and isoelectrofocussing (IEF) fractionated proteins. Eighty-three xylanases produced by these thermophilic and thermotolerant strains were detected using the IEF profiling technique. Xylanases identified on the basis of their isoelectric points (pI) were functionally diverse and exhibited differential catalytic activities against various xylan types (birch wood xylan, larch wood xylan, oat spelt xylan, rye arabino xylan and wheat arabino xylan) as well as debranched arabinan. Thermophilic isolates, Chaetomium thermophilum , Humicola insolens , Melanocarpus sp., Malbranchea sp. and Thermoascus aurantiacus , were found to produce alkaline active xylanases that showed a bleach boosting effect on Decker pulp resulting in increased brightness (1.60-2.04 ISO units).
An overview of the Australian biomass resources and utilization technologies
Authors: Moghtaderi Behdad , Sheng Changdong , Wall Terry F.
Published: September 2020

Information on Australian biomass resources including bagasse, black liquor from paper pulp production, wood waste and forestry residues, energy crops, crop wastes, food and agricultural wet waste, and municipal solid wastes is provided in the review. The characteristics of the Australian biomass are typical of those of other countries, i.e. high moisture and volatile matter, low heating value and density, and low sulfur and nitrogen content, but high Ca and Mg for woody biomass. The characteristics influence biomass utilization. Biomass is used extensively at present within Australia , primarily for domestic heating, as bagasse in the sugar industry, and for electricity generation. Biomass usage for electricity generation is increasing and is expected to reach 5.2 Mt/year by 2019-20. Exports, as wood chips, are approximately 10 Mt/year in 2000-01. Forestry residues have been estimated to be 23 Mt/year. Current technologies that utilize biomass in Australia include those for electricity and heat by direct combustion, cofiring with coal and fluidized bed combustion), for biogas generation (from landfills, and aerobic digestion, and as bio-liquids. Related to bio-liquid fuels, ethanol production from molasses and wheat is making progress. The resultant ethanol is used as a petrol extender, and a bio-diesel process is under development.
Allelic variation in candidate genes associated with wood properties of cultivated
poplars (Populus)
Authors: Köbölkuti Zoltán Attila , Cseke Klára , Benke Attila , Báder Mátyás , Borovics Attila , Németh Róbert
Published: September 2020

Introduction

Since Populus has veritable value as timber, plywood,
pulp, and paper, genomic research should create the sound basis for further breeding
toward desirable wood quality attributes.

Materials and methods

In this study, we addressed the need for a research methodology that initially
identifies and then characterize candidate genes encoding enzymes with wood property
phenotypic traits, toward the aim of developing a genomics-based breeding
technology.

Results

On 23 different poplar species/hybrid samples, we successfully amplified 55
primers designed on Populus trichocarpa L. Considering the
number of polymorphic sites, out of 73,206 bp, 51 SNPs and 31 indel events were found.
Non-synonymous single base mutations could be detected in number of 30, 21 out of 164
sequences were the number of minimum recombination events and 41 significant pairwise
comparisons between loci could be detected.

Discussion and conclusion

Our results provide a roadmap for a future association genetic study between
nucleotide diversity and precise evaluation of phenotype.
In-vitro and in-silico anticancer potential of taxoids from Taxus wallichiana
Zucc
Authors: Qayum Mughal , Nisar Muhammad , Rauf Abdur , Khan Imran , Kaleem Waqar Ahmad , Raza Muslim , Karim Nasiara , Saleem Munawar Ahmad , Bawazeer Saud , Uysal Sengul , Zengin Gokhan , Jahan Saqib , Ramadan Mohamed Fawzy
Published: September 2020

Introduction

Natural products derived from medicinal plants provide beneficial cancer
chemotherapeutic drugs. Bioactive constituents from plants are explored for their
anticancer properties.

Methods

Three known compounds (deacetylbaccatin III, tasumatrol B, and taxawallin J)
were isolated from Taxus wallichiana. Compounds were
screened against four cancer cell lines, such as eA498, HepG2, NCI-H226, and MDR
2780AD. Cytotoxic activity was evaluated using MTT assay against cancer cell
lines.

Results

Tasumatrol B showed good cytotoxic activity conducted for the improvement of
inhibiting potential of these compounds against the cancer drug target protein (EGFR
tyrosine kinase enzyme). The docking study showed that all compounds have binding
affinities and interaction profile with the receptor tyrosine kinase.

Discussion

The study suggests that these compounds could be used for the discovery of novel
inhibitors against the target receptors for the treatment of cancer.
The reducing effect of agomelatine on pentylenetetrazol-induced convulsions
Authors: Demirel Esra Aciman , Erdoğan Mumin Alper , Cinar Bilge Piri , Erbas Oytun
Published: September 2020

Introduction

Agomelatine is a potent MT1 and MT2 melatonin receptor agonist and a 5-HT2C
serotonin receptor antagonist. The purpose of this study was to show the
convulsion-reducing effect of agomelatine, in both clinical and electrophysiological
terms, in a pentylenetetrazole (PTZ)-induced experimental epilepsy model in
rats.

Methods

The anticonvulsant activity of agomelatine (25 and 50 mg/kg) was evaluated in
rat models of PTZ (35 and 70 mg/kg) and compared with the control groups.

Results

Agomelatine administration at doses of 25 and 50 mg/kg resulted in a
statistically significant decrease in convulsion scores and time to onset of myoclonic
jerks compared to the control groups. In addition, comparison of the two doses
employed showed that high-dose agomelatine (50 mg/kg) was significantly more effective
than the lower dose. In addition to previous studies, we investigated the
anticonvulsant effect of agomelatine using electroencephalogram (EEG). Administration
of agomelatine at doses of 25 and 50 mg/kg in PTZ-induced seizures caused a
significant decrease in the percentage of peak at EEG.

Discussion

Our results suggest that agomelatine has anticonvulsant activity shown in
PTZ-induced seizure model. The results also give some evidences that agomelatine can
use on epileptic seizures, but more studies are needed.
A cilostazol diabeteses betegekben is javítja az életminőséget és az alsó végtagi funkcionális kapacitást
Authors: Farkas Katalin , Kolossváry Endre , Járai Zoltán
Published: September 2020

Absztrakt:

Bevezetés: A claudicatio intermittens jelentős negatív hatással
van a betegek életminőségére. A különböző revascularisatiós eljárások és a
noninvazív orvosi kezelések javíthatják a betegek járását. A cilostazol I.A
ajánlással rendelkezik a claudicatio intermittens kezelésére.
Célkitűzés: Vizsgálatunk célja a 3 hónapos
cilostazolkezelésnek az egészséggel kapcsolatos életminőségre és az alsó végtag
funkcionális kapacitására gyakorolt hatásának értékelése a klinikai
gyakorlatban, claudicatio intermittensben szenvedő diabeteses (DM) és nem
diabeteses (NDM) betegek körében. Módszer: A tanulmány
multicentrikus, beavatkozással nem járó vizsgálat, amelybe 812, ambuláns kezelés
alatt álló, perifériás verőérbetegségben szenvedő beteg (Fontaine II. stádium,
átlagéletkor: 67,17 év, férfi/nő: 58,25/41,75%, 318 diabeteses) került
beválasztásra, akik cilostazolkezelést kaptak (50 vagy 100 mg naponta kétszer) 3
hónapig. Az életminőséget az EQ-5D-3L-kérdőívvel, a funkcionális kapacitást a
WELCH-kérdőívvel értékeltük. A fájdalommentes és maximális járástávolságnak,
valamint a boka-kar indexnek a mérése megtörtént a vizsgálat indulásakor és a 3
hónapos kezelés után. Eredmények: A vizsgálat befejezése után
az EQ-5D-index javult (kiindulási érték: NDM –0,45 ± 0,22, DM –0,48 ± 0,23, 3.
hónap: –0,24 ± 0,18, –0,27 ± 0,19; p<0,0001), és a WELCH-pontszám szintén
szignifikánsan nőtt (kiindulási érték: NDM 20 ± 14, DM 18 ± 14; 3. hónap: 33 ±
19, 29 ± 16; p<0,0001) mindkét betegcsoportban. Mind a fájdalommentes, mind a
maximális járástávolság nőtt: NDM 59,2% (medián: 50,0%), 46,58 (medián: 40,51%),
és DM 42,85% (medián: 43,33%), 41,61% (medián: 34,68%) (p<0,001).
Következtetés: 3 hónapos cilostazolkezelés javította az
életminőséget és az alsó végtagi funkcionális kapacitást claudicatio
intermittensben szenvedő betegekben, diabetes esetén is. A WELCH-kérdőív hasznos
eszköznek bizonyult a klinikai gyakorlatban a claudicatio kezelése során a
járóképesség értékelésére. Orv Hetil. 2020; 161(38): 1637–1645.
Studi Pengaruh Anion Asetat Terhadap Kelarutan Li2CO3 sebagai Dasar Recovery Litium pada Kondisi Terlindi Asam Asetat
Authors: Wicaksono Muhamad Fajar Wicaksono Fajar , Perdana Indra , Sutijan Sutijan
Published: September 2020

Litium karbonat, salah satu bentuk senyawa litium yang paling sering dihasilkan pada proses daur ulang baterai bekas. Pada industri proses mineral, pembentukan senyawa litium karbonat disintesis pada kondisi adanya anion-anion ikutan yang berasal dari proses pelindian. Pada beberapa dekade, penggunaan larutan pelindi anorganik mulai ditinggalkan dan beralih ke pelindi organik. Salah satu asam organik yang memberikan hasil recovery leaching tertinggi adalah asam asetat, akan tetapi pembentukan litium karbonat dalam larutan yang mengandung anion asetat sulit dilakukan yang dikarenakan efek anion asetat terhadap kelarutan litium karbonat belum teridentifikasi,  Pada penelitian ini, dipelajari pengaruh anion asetat dalam pengendapan litium karbonat dan dari hasil ini didapatkan bahwa pengaruh konsentrasi asetat bersifat non linear terhadap kelarutan litium karbonat dan disimpulkan bahwa konsentrasi asetat 0,2 mol memberikan kelarutan terendah terhadap litium karbonat. Dengan informasi tersebut, maka diharapkan permasalahan recovery litium karbonat pada larutan pelindi asetat dapat terselesaikan.
Persepsi dan Partisipasi Masyarakat terhadap Ekosistem Mangrove di Distrik Sorong Timur, Kota Sorong Provinsi Papua Barat
Authors: Handayani Handayani , Mustasim Mustasim , Amir M Suruwaky
Published: September 2020

Penelitian ini merupakan kajian persepsi dan partisipasi masyarakat terhadap ekosistem mangrove di Distrik Sorong Timur, Kota Sorong. Penelitian menggunakan metode deskriptif dengan teknik pengambilan data kuesioner dan observasi. Pengolahan data dilakukan dengan tabulasi dan dinyatakan dalam bentuk grafik dan diagram. Hasil penelitian menunjukkan 63% responden menyatakan bahwa ekosistem mangrove di wilayah mereka telah berkurang. Persepsi responden terhadap pengambilan mangrove untuk kebutuhan kayu bakar yang menyatakan setuju sebesar 44% dan menyatakan tidak setuju sebesar 48%, sedangkan persepsi masyarakat mengenai penebangan mangrove untuk bahan bangunan 53% menyatakan tidak setuju dan 40% menyatakan setuju. Kaitan dengan alih fungsi ekosistem menjadi tambak/permukiman maka 65% responden tidak setuju. Partisipasi masyakarat dalam pelestarian ekosistem mangrove sangat rendah yakni 83%. Masyarakat berharap adanya sosialisasi Pemerintah Daerah Kota Sorong atau pemerhati lingkungan dalam pelestarian ekosistem mangrove.
The therapist's emotional presence and its interactional functions in promoting client change in relationship-focused integrative psychotherapy
Authors: Pawelczyk Joanna
Published: September 2020

Therapeutic alliance is often posed as an explanation for why therapy works, and there seems to be a consistent finding that the stronger the alliance, the greater the therapeutic change. Although extensively documented in the professional literature as an essential aspect of therapeutic alliance, the concept of emotional presence and its actualization in moment-by-moment interaction have not been adequately described. This paper applies integrative qualitative methodology, including tools and insights from discourse analysis and conversation analysis, to five extracts of Relationship-focused Integrative Psychotherapy sessions with three different clients. It examines the concept of emotional presence operationalized in terms of the therapist's invoking the client's immediate experience. The analytical focus falls on an interactive sequence involving the therapist's topicalization of the client's (proffered) non-verbal cues aiming at eliciting emotion talk in the interactional here-and-now and the latter's orientation to it. The psychotherapist's strategy of emotional presence is proposed to play a salient role in promoting the client's (gradual) change by focusing the talk on the client's here-and-now experience. Thus clients are prompted to project their emotions and/or engage in overt self-reflexive examination of emotional and relational patterns in the immediate context of their concrete trouble-telling. By being regularly exposed to such practices in therapy, clients are instilled with a sense of being in touch with how they feel about a particular situation or person.
Starting points for therapeutic change
Authors: Scarvaglieri Claudio
Published: September 2020

Based on a corpus of 70 tape-recorded therapy sessions (client-centered therapy, psychodynamic therapy), this paper presents analyses of therapists’ interventions that have the potential to trigger change processes. Using a conversation analytic approach, we identify utterances that re-formulate the patient's experience from a different perspective. In a second step, we draw on concepts from cognitive and pragmatic linguistics, mainly “frame” and “category”, to analyze the conceptual side of these rewordings. We show that, besides processes of general abstraction, the conceptualization of the patient's experience from a societal perspective is a crucial part of the rewordings. The verbal re-framing creates a potential for accessing stocks of societal knowledge that would not have been accessible based on the patient's initial, individualistic and often erratic presentation of events. By changing the wording an experience is referred to, the therapist thus creates links to established collective knowledge about experiences of this category. Once such links to collective knowledge have been created, it then becomes possible to understand differently how the experience in question came to pass, which features it is characterized by and how it can be dealt with in a way that is collectively known to be helpful.
The role of cognitive science and artificial intelligence in supporting clinical diagnosis
Authors: Lucchiari Claudio , Vanutelli Maria Elide , Folgieri Raffaella
Published: September 2020

Research suggests that doctors are failing to make use of technologies designed to optimize their decision-making skills in daily clinical activities, despite a proliferation of electronic tools with the potential for decreasing risks of medical and diagnostic errors. This paper addresses this issue by exploring the cognitive basis of medical decision making and its psychosocial context in relation to technology. We then discuss how cognitive-led technologies – in particular, decision support systems and artificial neural networks – may be applied in clinical contexts to improve medical decision making without becoming a substitute for the doctor's judgment. We identify critical issues and make suggestions regarding future developments.
Understanding change in psychotherapy
Authors: Pawelczyk Joanna , Graf Eva-Maria
Published: September 2020

Guest Editorial
Clinically rethinking CA-studies to improve therapeutic conversation
Authors: Buchholz Michael
Published: September 2020

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Psychotherapy
Authors: Vehviläinen Sanna
Published: September 2020

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Development and evaluation of the effectiveness of an individual educational route for a younger student with disabilities
Authors: Kolosova Elena
Published: September 2020

In this article existing approaches to the development and implementation of an individual educational route for a younger student in an inclusive school environment were analyzed. This work was carried out as part of the dissertation research. The author presents the results of a comparative analysis of regulatory and pedagogical literature, revealing the content of such concepts as individual educational trajectory, educational environment, educational space, individual educational route, and individual curriculum.
The contradictions between modern scientific ideas about the essence of an individual path in education for normatively developing children and its reduction in inclusive practice to a consolidated plan of correctional and developmental work are revealed. If in the first case, the role of the student is characterized by subjectivity, the goals of individualization of education are associated with the identification and implementation of the cognitive interests and inclinations of the child, and the role of the teacher is to provide pedagogical support and facilitation, to promote educational ideas, trials, then in the situation of developing an individual educational route for a student with disabilities of health in the center of attention is his nosology. The "route" here represents the stages of the correctional and developmental work of specialists, which is a necessary condition for the child's life, his development, but not the only tool for the individualization of education, understood as the process and result of building a person's image through the development of culture in ways that are adequate for him, at a pace and choice of content...
The article proposes the author's interpretation of the concept of an individual educational route for a child with disabilities, identifies the structural components, highlights the participants contributing to its formation. As the basic resources of the variable educational environment, based on this environment an individual educational route is designed, it is proposed to consider the spheres of additional and informal education. The author presents a semi-structured interview as a pedagogical tool that allows you to design an individual educational route and evaluate its effectiveness within the framework of an anthropological approach to education. The proposed semi-structured interview as a pedagogical toolkit is intended for use in group work with the inclusion of a family raising a child with disabilities, a teacher of additional education, and other members of the inclusive community.
The results and conclusions of the article, the described stages of the semi-structured interview can be used in the work of psychological and pedagogical councils of general education schools that implement educational programs for children with special educational needs.
Inversão geracional na família: repercussões da parentalização na vida adulta
Authors: Mello Renata , Féres-Carneiro Terezinha , Machado Rebeca Nonato , Magalhães Andrea Seixas
Published: September 2020

Resumo Este trabalho discute o processo de inversão geracional na família, tendo como enfoque as repercussões da parentalização na vida adulta. Inicialmente, investiga-se o conceito de parentalização, das primeiras impressões no campo psicanalítico à sua configuração no campo das psicoterapias de família. Em seguida, diferencia-se a noção de parentalização destrutiva da parentalização construtiva. Posteriormente, discute-se sobre as repercussões da parentalização na vida adulta, utilizando fragmentos de casos clínicos como ilustração. Considera-se que a inversão geracional em seu espectro crônico e amplo em suas dimensões gera dificuldades significativas para a construção de uma base pessoal segura e confiante na vida adulta, repercutindo no modo como os adultos parentalizados destrutivamente se relacionam com o outro. Tais relações transitam nos extremos, do desejo de fusão e proximidade absolutas ao desejo de distância e recusa do outro, tendo a insegurança e o medo do abandono como pano de fundo.
Bovine abortion by a vaccine strain of Bacillus anthracis
Authors: Bassuino Daniele Mariath , Siqueira Franciele Maboni , Konradt Guilherme , Vielmo Andréia , Rolim Verônica Machado , Gonçalves Maiara Aline , Cibulski Samuel Paulo , Snel Gustavo , Mayer Fabiana Quoos , Vargas Agueda Castagna de , Driemeier David , Pavarini Saulo Petinatti
Published: September 2020

ABSTRACT: This paper reports the abortion of a male Aberdeen Angus bovine by a vaccine strain of Bacillus anthracis, describing the pathological and microbiological findings and the genome sequence. Necropsy findings included multifocal areas of hemorrhage in different organs. Histologically, various organs showed hemorrhage, fibrin exudation, necrosis associated with countless bacillary bacterial clumps and severe neutrophilic inflammatory infiltrate. In the microbiological examination, numerous rough, nonhemolytic, gray and dry colonies with irregular edges were isolated from liver, lung and abomasum content samples. Gram staining revealed square-ended Gram-positive rods arranged in chains. B. anthracis identification was confirmed by detection of the molecular chromosomal marker Ba813. The genomes from the isolated B. anthracis (named SPV842_15) and from the isolated vaccinal strain (Brazilian vaccinal strain), which was recovered from a commercial vaccine used in the pregnant cow, were sequenced. Genomic comparisons displayed a high level of nucleotide identity in the comparisons between B. anthracis SPV842_15 and the B. anthracis Brazilian vaccinal strain (98,2%). Furthermore, in both strains, only the plasmid pX01 sequence was detected. Although, vaccination against anthrax is characterized by an elevated protective profile and very low residual virulence, immunization with Sterne strains can cause abortion in cattle, presumably by the plasmid pX01 toxins in rare or special situations.
An enterprise model on Sensing, Smart, and Sustainable (S
Authors: Sousa Thales Botelho de , Yamanari Juliana Suemi , Guerrini Fábio Müller
Published: September 2020

Abstract Organizations are being highly pressured to increase their competitiveness in order to deal with dynamic and turbulent markets. The development of an intelligent manufacturing system has been identified as an effective way to increase the competitiveness of enterprises. Traditional companies need models, skills, processes, and technologies to face the challenges imposed by today´s highly competitive markets, which require constant innovation. Sensing, Smart, and Sustainable (S^3) Enterprises play an important role in the digitization of strategies, decisions, and operations. They become efficient in facing the challenges intrinsic to the digital economy and intelligent manufacturing by applying the concepts of detection and monitoring, intelligence, and sustainability. The extant literature indicates the need for the development of methods and enterprise models that portray the reality of S^3 Enterprises. This paper presents an enterprise model to facilitate the formalization of S^3 Enterprises and help understand the dynamics of their operations. Applying the For Enterprise Modeling (4EM) method, this proposed enterprise model documents the goals, business rules, processes, and concepts of S^3 Enterprises. The contribution of this paper is the identification of guiding principles that allow companies interested in applying the S^3 concepts to have a basic reference mapped through perspectives of different knowledge domains.
A solitary rough-toothed dolphin (Steno bredanensis) in a superport area on northern Rio de Janeiro State, SE Brazil
Authors: Di Beneditto Ana Paula Madeira , Siciliano Salvatore
Published: September 2020

Abstract: The solitary behavior is an unusual and peculiar behavior reported in a few sociable dolphin species. This study presents the solitary behavior of an adult rough-toothed dolphin, Steno bredanensis, in the Açu Superport (21º49’S; 041º00’W), northern Rio de Janeiro State, SE Brazil. Data about the dolphin were obtained from mobile phone videos and reports by local professionals. Probably, the same dolphin was there since 2017-2018 up to April 2020 (at least). In general, the solitary dolphin swims next to supply boats navigating along the port internal channel, and it rarely continues towards open sea. The dolphin plays with buoys and containment barriers, rubs itself against hulls, and bow-rides and jumps. There is no report of people swimming with this solitary dolphin, touching it, or offering it food in the Açu Superport. Thus, there seems to be no threats to the animal’s integrity locally.