bluuebunny/crossref_metadata_2025 huggingface dataset:
Moracin C, A Phenolic Compound Isolated from Artocarpus heterophyllus, Suppresses Lipopolysaccharide-Activated Inflammatory Responses in Murine Raw264.7 Macrophages
Authors: Yao Xue , Wu Dang , Dong Ningning , Ouyang Ping , Pu Jiaqian , Hu Qian , Wang Jingyuan , Lu Weiqiang , Huang Jin
Published: July 2016

Artocarpus heterophyllus, a popular tropical fruit commonly known as the jackfruit tree, is normally planted in subtropical or tropical areas. Since a variety of phytochemicals isolated from A. heterophyllus have been found to possess potently anti-inflammatory, antiviral and antimalarial activities, researchers have devoted much interest to its potential pharmaceutical value. However, the exact mechanism underlying its anti-inflammatory activity is not well characterized. In this study, seven natural products isolated from A. heterophyllus, including 25-Hydroxycycloart-23-en-3-one (HY), Artocarpin (AR), Dadahol A (DA), Morachalcone A (MA), Artoheterophyllin B (AB), Cycloheterophyllin (CY) and Moracin C (MC) were collected. Lipopolysaccharide (LPS)-stimulated inflammatory response in RAW264.7 macrophages were used in this study. Among these compounds, MC significantly inhibited LPS-activated reactive oxygen species (ROS) and nitric oxide (NO) release without marked cytotoxicity. Furthermore, MC effectively reduced LPS stimulated up-regulation of mRNA and protein expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and serval pro-inflammatory cytokines (interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α)). Mechanistic studies revealed that the anti-inflammatory effect of MC was associated with the activation of the mitogen activated protein kinases (MAPKs) (including p38, ERK and JNK) and nuclear factor-κB (NF-κB) pathways, especially reducing the nuclear translocation of NF-κB p65 subunit as revealed by nuclear separation experiment and confocal microscopy.
Non-Ligand-Induced Dimerization is Sufficient to Initiate the Signalling and Endocytosis of EGF Receptor
Authors: Kourouniotis George , Wang Yi , Pennock Steven , Chen Xinmei , Wang Zhixiang
Published: July 2016

The binding of epidermal growth factor (EGF) to EGF receptor (EGFR) stimulates cell mitogenesis and survival through various signalling cascades. EGF also stimulates rapid EGFR endocytosis and its eventual degradation in lysosomes. The immediate events induced by ligand binding include receptor dimerization, activation of intrinsic tyrosine kinase and autophosphorylation. However, in spite of intensified efforts, the results regarding the roles of these events in EGFR signalling and internalization is still very controversial. In this study, we constructed a chimeric EGFR by replacing its extracellular domain with leucine zipper (LZ) and tagged a green fluorescent protein (GFP) at its C-terminus. We showed that the chimeric LZ-EGFR-GFP was constitutively dimerized. The LZ-EGFR-GFP dimer autophosphorylated each of its five well-defined C-terminal tyrosine residues as the ligand-induced EGFR dimer does. Phosphorylated LZ-EGFR-GFP was localized to both the plasma membrane and endosomes, suggesting it is capable of endocytosis. We also showed that LZ-EGFR-GFP activated major signalling proteins including Src homology collagen-like (Shc), extracellular signal-regulated kinase (ERK) and Akt. Moreover, LZ-EGFR-GFP was able to stimulate cell proliferation. These results indicate that non-ligand induced dimerization is sufficient to activate EGFR and initiate cell signalling and EGFR endocytosis. We conclude that receptor dimerization is a critical event in EGF-induced cell signalling and EGFR endocytosis.
Anti-Diabetic Effect of Portulaca oleracea L. Polysaccharideandits Mechanism in Diabetic Rats
Authors: Bai Yu , Zang Xueli , Ma Jinshu , Xu Guangyu
Published: July 2016

Diabetes mellitus (DM) is a metabolic syndrome caused by multiple genetic and environmental factors. Traditional Chinese medicine preparations have shown a comprehensive and function-regulating characteristic. Purslane (Portulaca oleracea L.) is an annual succulent herb. Currently, there have been some related reports on the treatment of diabetes with purslane. The current study was designed to separate and purify the polysaccharide, a systematic study of its physical and chemical properties, antioxidant activity, and anti-diabetic mechanism, in order to provide a theoretical basis for the development of drugs of purslane. A crude water soluble polysaccharide extracted from purslane was named CPOP (crude Portulaca oleracea L. polysaccharide). Effects of CPOP on bodyweight, glucose tolerance test (GTT), fasting blood glucose (FBG), fasting serum insulin (FINS), insulin sensitivity index (ISI), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), methane dicarboxylic aldehyde (MDA), and superoxygen dehydrogenises (SOD) were investigated. The results indicate that the oral administration of CPOP could significantly increase the body weight and significantly improve the glucose tolerance in diabetic rats. Meanwhile, CPOP could significantly reduce the FBG level, and elevate the FINS level and ISI value in diabetic rats. In addition, CPOP could significantly reduce TNF-α and IL-6 levels in diabetic rats; CPOP could also reduce MDA and SOD activities in the liver tissue of diabetic rats. These results suggest that the anti-diabetic effect of CPOP may be associated with its antioxidant and anti-inflammatory effects.
Role of Lipids in the Onset, Progression and Treatment of Periodontal Disease. A Systematic Review of Studies in Humans
Authors: Varela-López Alfonso , Giampieri Francesca , Bullón Pedro , Battino Maurizio , Quiles José
Published: July 2016

The risk of different oral problems (root caries, tooth mobility, and tooth loss) can be increased by the presence of periodontal disease, which has also been associated with a growing list of systemic diseases. The presence of some bacteria is the primary etiology of this disease; a susceptible host is also necessary for disease initiation. In this respect, the progression of periodontal disease and healing of the periodontal tissues can be modulated by nutritional status. To clarify the role of lipids in the establishment, progression, and/or treatment of this pathology, a systematic review was conducted of English-written literature in PubMed until May 2016, which included research on the relationship of these dietary components with the onset and progression of periodontal disease. According to publication type, randomized-controlled trials, cohort, case-control and cross-sectional studies were included. Among all the analyzed components, those that have any effect on oxidative stress and/or inflammation seem to be the most interesting according to current evidence. On one hand, there is quite a lot of information in favor of a positive role of n-3 fatty acids, due to their antioxidant and immunomodulatory effects. On the other hand, saturated fat-rich diets increase oxidative stress as well the as intensity and duration of inflammatory processes, so they must be avoided.
Weathering Characteristics of Wood Plastic Composites Reinforced with Extracted or Delignified Wood Flour
Authors: Chen Yao , Stark Nicole , Tshabalala Mandla , Gao Jianmin , Fan Yongming
Published: July 2016

This study investigated weathering performance of an HDPE wood plastic composite reinforced with extracted or delignified wood flour (WF). The wood flour was pre-extracted with three different solvents, toluene/ethanol (TE), acetone/water (AW), and hot water (HW), or sodium chlorite/acetic acid. The spectral properties of the composites before and after artificial weathering under accelerated conditions were characterized by Fourier transform infrared (FTIR) spectroscopy, the surface color parameters were analyzed using colorimetry, and the mechanical properties were determined by a flexural test. Weathering of WPC resulted in a surface lightening and a decrease in wood index (wood/HDPE) and flexural strength. WPCs that were reinforced with delignified wood flour showed higher ΔL* and ΔE* values, together with lower MOE and MOR retention ratios upon weathering when compared to those with non-extracted control and extracted WF.
Vanadium Pentoxide Nanobelt-Reduced Graphene Oxide Nanosheet Composites as High-Performance Pseudocapacitive Electrodes: ac Impedance Spectroscopy Data Modeling and Theoretical Calculations
Authors: Gupta Sanju , Aberg Bryce , Carrizosa Sara , Dimakis Nicholas
Published: July 2016

Graphene nanosheets and graphene nanoribbons, G combined with vanadium pentoxide (VO) nanobelts (VNBs) and VNBs forming GVNB composites with varying compositions were synthesized via a one-step low temperature facile hydrothermal decomposition method as high-performance electrochemical pseudocapacitive electrodes. VNBs from vanadium pentoxides (VO) are formed in the presence of graphene oxide (GO), a mild oxidant, which transforms into reduced GO (rGOHT), assisting in enhancing the electronic conductivity coupled with the mechanical robustness of VNBs. From electron microscopy, surface sensitive spectroscopy and other complementary structural characterization, hydrothermally-produced rGO nanosheets/nanoribbons are decorated with and inserted within the VNBs’ layered crystal structure, which further confirmed the enhanced electronic conductivity of VNBs. Following the electrochemical properties of GVNBs being investigated, the specific capacitance Csp is determined from cyclic voltammetry (CV) with a varying scan rate and galvanostatic charging-discharging (V–t) profiles with varying current density. The rGO-rich composite V1G3 (i.e., VO/GO = 1:3) showed superior specific capacitance followed by VO-rich composite V3G1 (VO/GO = 3:1), as compared to V1G1 (VO/GO = 1:1) composite, besides the constituents, i.e., rGO, rGOHT and VNBs. Composites V1G3 and V3G1 also showed excellent cyclic stability and a capacitance retention of >80% after 500 cycles at the highest specific current density. Furthermore, by performing extensive simulations and modeling of electrochemical impedance spectroscopy data, we determined various circuit parameters, including charge transfer and solution resistance, double layer and low frequency capacitance, Warburg impedance and the constant phase element. The detailed analyses provided greater insights into physical-chemical processes occurring at the electrode-electrolyte interface and highlighted the comparative performance of thin heterogeneous composite electrodes. We attribute the superior performance to the open graphene topological network being beneficial to available ion diffusion sites and the faster transport kinetics having a larger accessible geometric surface area and synergistic integration with optimal nanostructured VO loading. Computational simulations via periodic density functional theory (DFT) with and without V2O5 adatoms on graphene sheets are also performed. These calculations determine the total and partial electronic density of state (DOS) in the vicinity of the Fermi level (i.e., higher electroactive sites), in turn complementing the experimental results toward surface/interfacial charge transfer on heterogeneous electrodes.
Halichoblelide D, a New Elaiophylin Derivative with Potent Cytotoxic Activity from Mangrove-Derived Streptomyces sp. 219807
Authors: Han Ying , Tian Erli , Xu Dongbo , Ma Min , Deng Zixin , Hong Kui
Published: July 2016

During our search for interesting bioactive secondary metabolites from mangrove actinomycetes, the strain Streptomyces sp. 219807 which produced a high elaiophylin yield of 4486 mg/L was obtained. A new elaiophylin derivative, halichoblelide D (1), along with seven known analogues 2–8 was isolated and identified from the culture broth. Their chemical structures were determined by detailed analysis of 1D and 2D NMR and HRMS data. The absolute configuration of halichoblelide D (1) was confirmed by comparing the CD spectrum with those of the reported analogues. Compounds 1–7 exhibited potent cytotoxic activities against HeLa and MCF-7 cells with IC50 values ranging from 0.19 to 2.12 μM.
Iodine Status of New Zealand Elderly Residents in Long-Term Residential Care
Authors: Miller Jody , MacDonell Sue , Gray Andrew , Reid Malcolm , Barr David , Thomson Christine , Houghton Lisa
Published: July 2016

In response to the re-emergence of iodine deficiency in New Zealand, in 2009 the government mandated that all commercially made breads be fortified with iodized salt. There has been no evaluation of the impact of the program on iodine status of the elderly, despite this population group being vulnerable to iodine deficiency or excess. The aim of this study was to describe the iodine status of elderly New Zealanders in residential aged-care homes following the implementation of the bread fortification program. A cross-sectional survey was conducted, involving 309 residents (median age 85 years) from 16 aged-care homes throughout NZ. Information on socio-demographic, anthropometric, dietary and health characteristics were collected. Casual spot urine samples were analysed for urinary iodine concentration (UIC). Blood samples were analysed for serum thyroglobulin, thyroglobulin antibodies, and other biochemical indices. The median UIC (MUIC) of the residents was 72 μg/L, indicating mild iodine deficiency, and 29% had a UIC < 50 μg/L. Median thyroglobulin concentration was 18 ng/mL and 26% had elevated thyroglobulin concentration (>40 ng/mL), suggesting iodine insufficiency. Diuretic use was associated with lower MUIC (p = 0.043). Synthetic thyroxine use was associated with lower odds of having a UIC < 50 μg/L (OR 0.32, p = 0.030)) and lower median thyroglobulin (−15.2 ng/mL, p = 0.001), compared with untreated participants. Frailty was associated with elevated thyroglobulin (p = 0.029), whereas anemia was associated with lower thyroglobulin (p = 0.016). Iodine insufficiency persists in New Zealanders residing in residential aged-care homes despite increasing iodine intake from fortified bread. Research is required to establish optimal iodine intake and status in the elderly.
Zerumbone, a Phytochemical of Subtropical Ginger, Protects against Hyperglycemia-Induced Retinal Damage in Experimental Diabetic Rats
Authors: Tzeng Thing-Fong , Liou Shorong-Shii , Tzeng Yu-Cheng , Liu I-Min
Published: July 2016

Diabetic retinopathy (DR), the most ordinary and specific microvascular complication of diabetes, is a disease of the retina. Zerumbone (ZER) is a monocyclic sesquiterpene compound, and based on reports, it is the predominant bioactive compound from the rhizomes of Zingiber zerumbet. The aim of the current study is to evaluate the protective effect of zerumbone against DR in streptozotocin (STZ)-induced diabetic rats. STZ-diabetic rats were treated with ZER (40 mg/kg) once a day orally for 8 weeks. ZER administration significantly (p < 0.05) lowered the levels of plasma glucose (32.5% ± 5.7% lower) and glycosylated hemoglobin (29.2% ± 3.4% lower) in STZ-diabetic rats. Retinal histopathological observations indicated that disarrangement and reduction in thickness of retinal layers were reversed in ZER-treated diabetic rats. ZER downregulated both the elevated levels of advanced glycosylated end products (AGEs) and the higher levels of the receptors for AGEs (RAGE) in retinas of diabetic rats. What’s more, ZER significantly (p < 0.05) ameliorated diabetes-induced upregulation of tumor necrosis factor-α, interleukin (IL)-1 and IL-6. ZER also attenuated overexpression of vascular endothelial growth factor and intercellular adhesion molecule-1, and suppressed activation of nuclear factor (NF)-κB and apoptosis in the retinas of STZ-diabetic rats. Our results suggest ZER possesses retinal protective effects, which might be associated with the blockade of the AGEs/RAGE/NF-κB pathway and its anti-inflammatory activity.
Proximal Sensing and Digital Terrain Models Applied to Digital Soil Mapping and Modeling of Brazilian Latosols (Oxisols)
Authors: Silva Sérgio , Poggere Giovana , Menezes Michele , Carvalho Geila , Guilherme Luiz , Curi Nilton
Published: July 2016

Digital terrain models (DTM) have been used in soil mapping worldwide. When using such models, improved predictions are often attained with the input of extra variables provided by the use of proximal sensors, such as magnetometers and portable X-ray fluorescence scanners (pXRF). This work aimed to evaluate the efficiency of such tools for mapping soil classes and properties in tropical conditions. Soils were classified and sampled at 39 locations in a regular-grid design with a 200-m distance between samples. A pXRF and a magnetometer were used in all samples, and DTM values were obtained for every sampling site. Through visual analysis, boxplots were used to identify the best variables for distinguishing soil classes, which were further mapped using fuzzy logic. The map was then validated in the field. An ordinary least square regression model was used to predict sand and clay contents using DTM, pXRF and the magnetometer as predicting variables. Variables obtained with pXRF showed a greater ability for predicting soil classes (overall accuracy of 78% and 0.67 kappa index), as well as for estimating sand and clay contents than those acquired with DTM and the magnetometer. This study showed that pXRF offers additional variables that are key for mapping soils and predicting soil properties at a detailed scale. This would not be possible using only DTM or magnetic susceptibility.
A Network Coverage Information-Based Sensor Registry System for IoT Environments
Authors: Jung Hyunjun , Jeong Dongwon , Lee Sukhoon , On Byung-Won , Baik Doo-Kwon
Published: July 2016

The Internet of Things (IoT) is expected to provide better services through the interaction of physical objects via the Internet. However, its limitations cause an interoperability problem when the sensed data are exchanged between the sensor nodes in wireless sensor networks (WSNs), which constitute the core infrastructure of the IoT. To address this problem, a Sensor Registry System (SRS) is used. By using a SRS, the information of the heterogeneous sensed data remains pure. If users move along a road, their mobile devices predict their next positions and obtain the sensed data for that position from the SRS. If the WSNs in the location in which the users move are unstable, the sensed data will be lost. Consider a situation where the user passes through dangerous areas. If the user’s mobile device cannot receive information, they cannot be warned about the dangerous situation. To avoid this, two novel SRSs that use network coverage information have been proposed: one uses OpenSignal and the other uses the probabilistic distribution of the users accessing SRS. The empirical study showed that the proposed method can seamlessly provide services related to sensing data under any abnormal circumstance.
Test-Retest Reliability of an Automated Infrared-Assisted Trunk Accelerometer-Based Gait Analysis System
Authors: Hsu Chia-Yu , Tsai Yuh-Show , Yau Cheng-Shiang , Shie Hung-Hai , Wu Chu-Ming
Published: July 2016

The aim of this study was to determine the test-retest reliability of an automated infrared-assisted, trunk accelerometer-based gait analysis system for measuring gait parameters of healthy subjects in a hospital. Thirty-five participants (28 of them females; age range, 23–79 years) performed a 5-m walk twice using an accelerometer-based gait analysis system with infrared assist. Measurements of spatiotemporal gait parameters (walking speed, step length, and cadence) and trunk control (gait symmetry, gait regularity, acceleration root mean square (RMS), and acceleration root mean square ratio (RMSR)) were recorded in two separate walking tests conducted 1 week apart. Relative and absolute test-retest reliability was determined by calculating the intra-class correlation coefficient (ICC3,1) and smallest detectable difference (SDD), respectively. The test-retest reliability was excellent for walking speed (ICC = 0.87, 95% confidence interval = 0.74–0.93, SDD = 13.4%), step length (ICC = 0.81, 95% confidence interval = 0.63–0.91, SDD = 12.2%), cadence (ICC = 0.81, 95% confidence interval = 0.63–0.91, SDD = 10.8%), and trunk control (step and stride regularity in anterior-posterior direction, acceleration RMS and acceleration RMSR in medial-lateral direction, and acceleration RMS and stride regularity in vertical direction). An automated infrared-assisted, trunk accelerometer-based gait analysis system is a reliable tool for measuring gait parameters in the hospital environment.
Real Time 3D Facial Movement Tracking Using a Monocular Camera
Authors: Dong Yanchao , Wang Yanming , Yue Jiguang , Hu Zhencheng
Published: July 2016

The paper proposes a robust framework for 3D facial movement tracking in real time using a monocular camera. It is designed to estimate the 3D face pose and local facial animation such as eyelid movement and mouth movement. The framework firstly utilizes the Discriminative Shape Regression method to locate the facial feature points on the 2D image and fuses the 2D data with a 3D face model using Extended Kalman Filter to yield 3D facial movement information. An alternating optimizing strategy is adopted to fit to different persons automatically. Experiments show that the proposed framework could track the 3D facial movement across various poses and illumination conditions. Given the real face scale the framework could track the eyelid with an error of 1 mm and mouth with an error of 2 mm. The tracking result is reliable for expression analysis or mental state inference.
System Description and First Application of an FPGA-Based Simultaneous Multi-Frequency Electrical Impedance Tomography
Authors: Aguiar Santos Susana , Robens Anne , Boehm Anna , Leonhardt Steffen , Teichmann Daniel
Published: July 2016

A new prototype of a multi-frequency electrical impedance tomography system is presented. The system uses a field-programmable gate array as a main controller and is configured to measure at different frequencies simultaneously through a composite waveform. Both real and imaginary components of the data are computed for each frequency and sent to the personal computer over an ethernet connection, where both time-difference imaging and frequency-difference imaging are reconstructed and visualized. The system has been tested for both time-difference and frequency-difference imaging for diverse sets of frequency pairs in a resistive/capacitive test unit and in self-experiments. To our knowledge, this is the first work that shows preliminary frequency-difference images of in-vivo experiments. Results of time-difference imaging were compared with simulation results and shown that the new prototype performs well at all frequencies in the tested range of 60 kHz–960 kHz. For frequency-difference images, further development of algorithms and an improved normalization process is required to correctly reconstruct and interpreted the resulting images.
Optical Analog to Electromagnetically Induced Transparency in Cascaded Ring-Resonator Systems
Authors: Wang Yonghua , Zheng Hua , Xue Chenyang , Zhang Wendong
Published: July 2016

The analogue of electromagnetically induced transparency in optical methods has shown great potential in slow light and sensing applications. Here, we experimentally demonstrated a coupled resonator induced transparency system with three cascaded ring coupled resonators in a silicon chip. The structure was modeled by using the transfer matrix method. Influences of various parameters including coupling ratio of couplers, waveguide loss and additional loss of couplers on transmission characteristic and group index have been investigated theoretically and numerically in detail. The transmission character of the system was measured by the vertical grating coupling method. The enhanced quality factor reached 1.22 × 105. In addition, we further test the temperature performance of the device. The results provide a new method for the manipulation of light in highly integrated optical circuits and sensing applications.
Betalain-Rich Concentrate Supplementation Improves Exercise Performance in Competitive Runners
Authors: Van Hoorebeke Justin , Trias Casey , Davis Brian , Lozada Christina , Casazza Gretchen
Published: July 2016

This study aimed to determine the effects of a betalain-rich concentrate (BRC) of red beets, containing antioxidant and anti-inflammatory properties, on performance and exercise-related muscle damage. Thirteen (25.3 ± 5.4 years) competitive male runners completed two double-blind, cross-over, randomized trials (BRC and control) separated by seven days. Each trial was preceded by six days of supplementation with 100 mg of BRC or control. On the seventh day, exercise trials commenced 150 min after supplementation with 50 mg BRC or control and consisted of 30 min of treadmill running (77 ± 4% VO2max) followed by a 5-km time trial (TT). During exercise at the same intensity, BRC resulted in a 3% lower heart rate, a 15% lower rate of perceived exertion (RPE) and a 14% lower blood lactate concentration compared to the control (p = 0.05). Five-kilometer TT duration (23.0 ± 4.2 versus 23.6 ± 4.0 min) was faster in 10 of the 13 subjects, and RPE was lower (p < 0.05) with the BRC treatment compared to the control. Lactate dehydrogenase, a marker of muscle damage, increased less from baseline to immediately and 30 min after the 5-km TT with the BRC treatment, despite no differences in subjective measures of muscle soreness and fatigue. In summary, BRC supplementation improved 5-km performance time in male competitive runners.
Conventional, Partially Converted and Environmentally Friendly Farming in South Korea: Profitability and Factors Affecting Farmers’ Choice
Authors: Lee Saem , Nguyen Trung , Poppenborg Patrick , Shin Hio-Jung , Koellner Thomas
Published: July 2016

While organic farming is well established in Europe a nd USA, it is still catching up in Asian countries. The government of South Korea has implemented environmentally friendly farming that encompasses organic farming. Despite the promotion of environmentally friendly farming, it still has a low share in South Korea and partially converted farming has emerged in some districts of South Korea. However, the partially converted farming has not yet been investigated by the government. Thus, our study implemented a financial analysis to compare the annual costs and net returns of conventional, partially converted and environmentally friendly farming in Gangwon Province. The result showed that environmentally friendly farming was more profitable with respect to farm net returns. To find out the factors affecting the adoption of environmentally friendly farming, multinomial logistic regression was implemented. The findings revealed that education and subsidy positively and significantly influenced the probability of farmers’ choice on partially converted and environmentally friendly farming. Farm size had a negative and significant relationship with only environmentally friendly farming. This study will contribute to future policy establishment for sustainable agriculture as recommended by improving the quality of fertilizers, suggesting the additional investigation associated with partially converted farmers.
Too Much Is as Bad as Too Little? Sources of the Intention-Achievement Gap in Sustainable Innovation
Authors: Yang Daegyu , Park Sangchan
Published: July 2016

Prior work on innovation has generally emphasized the importance of an organization’s exposure to external knowledge. This study, in contrast, redirects our attention toward conditions under which such exposure serves as constraints on organizational endeavors to achieve environmentally preferable innovation. We develop a two-stage model for sustainable innovation. A firm in the first stage explores a variety of alternatives and develops strategic intentions to address broader environmental concerns; thus, it may benefit from access to both diverse sources of external knowledge and network ties that enable an extensive search for new information. In the second stage, a firm exploits limited available options to achieve its strategic intentions. We suggest that dependence on external knowledge in the first stage makes the transition toward the second stage challenging, thereby reducing the probability that a firm’s strategic intentions for sustainability result in actual innovation outcomes. We test our theory using the 2014 Korean Innovation Survey. Our results show that diverse sources of external knowledge through rich network ties, albeit the positive main effects on innovation outcomes, negatively moderate the relationship between a firm’s intentions for environmental sustainability and its achievement of sustainable innovation. Several theoretical and practical implications are discussed.
Viral RNA Silencing Suppression: The Enigma of Bunyavirus NSs Proteins
Authors: Hedil Marcio , Kormelink Richard
Published: July 2016

The Bunyaviridae is a family of arboviruses including both plant- and vertebrate-infecting representatives. The Tospovirus genus accommodates plant-infecting bunyaviruses, which not only replicate in their plant host, but also in their insect thrips vector during persistent propagative transmission. For this reason, they are generally assumed to encounter antiviral RNA silencing in plants and insects. Here we present an overview on how tospovirus nonstructural NSs protein counteracts antiviral RNA silencing in plants and what is known so far in insects. Like tospoviruses, members of the related vertebrate-infecting bunyaviruses classified in the genera Orthobunyavirus, Hantavirus and Phlebovirus also code for a NSs protein. However, for none of them RNA silencing suppressor activity has been unambiguously demonstrated in neither vertebrate host nor arthropod vector. The second part of this review will briefly describe the role of these NSs proteins in modulation of innate immune responses in mammals and elaborate on a hypothetical scenario to explain if and how NSs proteins from vertebrate-infecting bunyaviruses affect RNA silencing. If so, why this discovery has been hampered so far.
Evaluation of the Performance and the Predictive Capacity of Build-Up and Wash-Off Models on Different Temporal Scales
Authors: Al Ali Saja , Bonhomme Céline , Chebbo Ghassan
Published: July 2016

Stormwater quality modeling has arisen as a promising tool to develop mitigation strategies. The aim of this paper is to assess the build-up and wash-off processes and investigate the capacity of several water quality models to accurately simulate and predict the temporal variability of suspended solids concentrations in runoff, based on a long-term data set. A Markov Chain Monte-Carlo (MCMC) technique is applied to calibrate the models and analyze the parameter’s uncertainty. The short-term predictive capacity of the models is assessed based on inter- and intra-event approaches. Results suggest that the performance of the wash-off model is related to the dynamic of pollutant transport where the best fit is recorded for first flush events. Assessment of SWMM (Storm Water Management Model) exponential build-up model reveals that better performance is obtained on short periods and that build-up models relying only on the antecedent dry weather period as an explanatory variable, cannot predict satisfactorily the accumulated mass on the surface. The predictive inter-event capacity of SWMM exponential model proves its inability to predict the pollutograph while the intra-event approach based on data assimilation proves its efficiency for first flush events only. This method is very interesting for management practices because of its simplicity and easy implementation.
Customized MFM probes with high lateral resolution
Authors: Iglesias-Freire Óscar , Jaafar Miriam , Berganza Eider , Asenjo Agustina
Published: July 2016

Magnetic force microscopy (MFM) is a widely used technique for magnetic imaging. Besides its advantages such as the high spatial resolution and the easy use in the characterization of relevant applied materials, the main handicaps of the technique are the lack of control over the tip stray field and poor lateral resolution when working under standard conditions. In this work, we present a convenient route to prepare high-performance MFM probes with sub-10 nm (sub-25 nm) topographic (magnetic) lateral resolution by following an easy and quick low-cost approach. This allows one to not only customize the tip stray field, avoiding tip-induced changes in the sample magnetization, but also to optimize MFM imaging in vacuum (or liquid media) by choosing tips mounted on hard (or soft) cantilevers, a technology that is currently not available on the market.
One-pot synthesis of 4′-alkyl-4-cyanobiaryls on the basis of the terephthalonitrile dianion and neutral aromatic nitrile cross-coupling
Authors: Peshkov Roman Yu , Panteleeva Elena V , Chunyan Wang , Tretyakov Evgeny V , Shteingarts Vitalij D
Published: July 2016

A convenient one-pot approach to alkylcyanobiaryls is described. The method is based on biaryl cross-coupling between the sodium salt of the terephthalonitrile dianion and a neutral aromatic nitrile in liquid ammonia, and successive alkylation of the long-lived anionic intermediate with alkyl bromides. The reaction is compatible with benzonitriles that contain methyl, methoxy and phenyl groups, fluorine atoms, and a 1-cyanonaphthalene residue. The variety of ω-substituted alkyl bromides, including an extra bromine atom, a double bond, cyano and ester groups, as well as a 1,3-dioxane fragment are suitable as alkylation reagents.
DYNAMICAL ESTIMATE OF POST-MAIN-SEQUENCE STELLAR MASSES IN 47 TUCANAE
Authors: Parada Javiera , Richer Harvey , Heyl Jeremy , Kalirai Jason , Goldsbury Ryan
Published: July 2016

We use the effects of mass segregation on the radial distribution of different stellar populations in the core of 47 Tucanae to find estimates for the masses of stars at different post-main-sequence evolutionary stages. We take samples of main-sequence (MS) stars from the core of 47 Tucanae, at different magnitudes (i.e., different masses), and use the effects of this dynamical process to develop a relation between the radial distance (RD) at which the cumulative distribution reaches the 20th and 50th percentile and stellar mass. From these relations we estimate the masses of different post-MS populations. We find that mass remains constant for stars going through the evolutionary stages from the upper MS up to the horizontal branch (HB). By comparing RDs of the HB stars with stars of lower masses, we can exclude a mass loss greater than

during the red giant branch (RGB) stage at nearly the

level. The slightly higher mass estimates for the asymptotic giant branch (AGB) are consistent with the AGB having evolved from somewhat more massive stars. The AGB also exhibits evidence of contamination by more massive stars, possibly blue straggler stars (BSSs), going through the RGB phase. We do not include the BSSs in this paper due to the complexity of these objects; instead, the complete analysis of this population is left for a companion paper. The process to estimate the masses described in this paper is exclusive to the core of 47 Tuc.
PROPERTIES OF MICROLENSING EVENTS BY WIDE-SEPARATION PLANETS WITH A MOON
Authors: Chung Sun-Ju , Ryu Yoon-Hyun
Published: July 2016

We investigate the properties of microlensing events caused by planetary systems where planets with a moon are widely separated from their host stars. From this investigation, we find that the moon feature generally appears as a very short-duration perturbation on the smooth asymmetric light curve of the lensing event induced by the wide-separation planet; thus it can be easily discriminated from the planet feature responsible for the overall asymmetric light curve. For typical Galactic lensing events with an Einstein radius of ∼2 au, the asymmetry of the light curves due to bound planets can be noticed up to ∼20 au. We also find that the perturbations of wide planetary systems become dominated by the moon as the projected star–planet separation increases, and eventually the light curves of events produced by such systems appear as the single lensing light curve of the planet itself with a very short-duration perturbation induced by the moon, which is a representative light curve of the event induced by a star and a planet, except on the Einstein timescale of the planet. We also study the effect of a finite source star on the moon feature in wide planetary lensing events. From this study, we find that when the lunar caustic is sufficiently separated from the planetary caustic, the lower limit on the ratio of the size of the lunar caustic to the source radius causing a ≥5% lunar deviation depends mostly on the projected planet–moon separation regardless of the moon/star mass ratio, and it decreases as the planet–moon separation becomes smaller or larger than the planetary Einstein radius.
THE JCMT GOULD BELT SURVEY: EVIDENCE FOR DUST GRAIN EVOLUTION IN PERSEUS STAR-FORMING CLUMPS
Authors: Chen Michael Chun-Yuan , Francesco J. Di , Johnstone D. , Sadavoy S. , Hatchell J. , Mottram J. C. , Kirk H. , Buckle J. , Berry D. S. , Broekhoven-Fiene H. , Currie M. J. , Fich M. , Jenness T. , Nutter D. , Pattle K. , Pineda J. E. , Quinn C. , Salji C. , Tisi S. , Hogerheijde M. R. , Ward-Thompson D. , Bastien P. , Bresnahan D. , Butner H. , Chrysostomou A. , Coude S. , Davis C. J. , Drabek-Maunder E. , Duarte-Cabral A. , Fiege J. , Friberg P. , Friesen R. , Fuller G. A. , Graves S. , Greaves J. , Gregson J. , Holland W. , Joncas G. , Kirk J. M. , Knee L. B. G. , Mairs S. , Marsh K. , Matthews B. C. , Moriarty-Schieven G. , Mowat C. , Pezzuto S. , Rawlings J. , Richer J. , Robertson D. , Rosolowsky E. , Rumble D. , Schneider-Bontemps N. , Thomas H. , Tothill N. , Viti S. , White G. J. , Wouterloot J. , Yates J. , Zhu M.
Published: July 2016

The dust emissivity spectral index, β, is a critical parameter for deriving the mass and temperature of star-forming structures and, consequently, their gravitational stability. The β value is dependent on various dust grain properties, such as size, porosity, and surface composition, and is expected to vary as dust grains evolve. Here we present β, dust temperature, and optical depth maps of the star-forming clumps in the Perseus Molecular Cloud determined from fitting spectral energy distributions to combined Herschel and JCMT observations in the 160, 250, 350, 500, and 850 μm bands. Most of the derived β and dust temperature values fall within the ranges of 1.0–2.7 and 8–20 K, respectively. In Perseus, we find the β distribution differs significantly from clump to clump, indicative of grain growth. Furthermore, we also see significant localized β variations within individual clumps and find low-β regions correlate with local temperature peaks, hinting at the possible origins of low-β grains. Throughout Perseus, we also see indications of heating from B stars and embedded protostars, as well evidence of outflows shaping the local landscape.
THE FIRST SPECTRUM OF THE COLDEST BROWN DWARF
Authors: Skemer Andrew J. , Morley Caroline V. , Allers Katelyn N. , Geballe Thomas R. , Marley Mark S. , Fortney Jonathan J. , Faherty Jacqueline K. , Bjoraker Gordon L. , Lupu Roxana
Published: July 2016

The recently discovered brown dwarf WISE 0855 presents the first opportunity to directly study an object outside the solar system that is nearly as cold as our own gas giant planets. However, the traditional methodology for characterizing brown dwarfs—near-infrared spectroscopy—is not currently feasible, as WISE 0855 is too cold and faint. To characterize this frozen extrasolar world we obtained a 4.5–5.2 μm spectrum, the same bandpass long used to study Jupiter’s deep thermal emission. Our spectrum reveals the presence of atmospheric water vapor and clouds, with an absorption profile that is strikingly similar to Jupiter’s. The spectrum quality is high enough to allow for the investigation of dynamical and chemical processes that have long been studied in Jupiter’s atmosphere, but now on an extrasolar world.
PROPERTIES AND MODELING OF UNRESOLVED FINE STRUCTURE LOOPS OBSERVED IN THE SOLAR TRANSITION REGION BY IRIS
Authors: Brooks David H. , Reep Jeffrey W. , Warren Harry P.
Published: July 2016

Recent observations from the Interface Region Imaging Spectrograph (IRIS) have discovered a new class of numerous low-lying dynamic loop structures, and it has been argued that they are the long-postulated unresolved fine structures (UFSs) that dominate the emission of the solar transition region. In this letter, we combine IRIS measurements of the properties of a sample of 108 UFSs (intensities, lengths, widths, lifetimes) with one-dimensional non-equilibrium ionization simulations, using the HYDRAD hydrodynamic model to examine whether the UFSs are now truly spatially resolved in the sense of being individual structures rather than being composed of multiple magnetic threads. We find that a simulation of an impulsively heated single strand can reproduce most of the observed properties, suggesting that the UFSs may be resolved, and the distribution of UFS widths implies that they are structured on a spatial scale of 133 km on average. Spatial scales of a few hundred kilometers appear to be typical for a range of chromospheric and coronal structures, and we conjecture that this could be an important clue for understanding the coronal heating process.
LONG-LIVED SPIRAL STRUCTURE FOR GALAXIES WITH INTERMEDIATE-SIZE BULGES
Authors: Saha Kanak , Elmegreen Bruce
Published: July 2016

Spiral structure in disk galaxies is modeled with nine collisionless N-body simulations including live disks, halos, and bulges with a range of masses. Two of these simulations make long-lasting and strong two-arm spiral wave modes that last for ∼5 Gyr with constant pattern speed. These two had a light stellar disk and the largest values of the Toomre Q parameter in the inner region at the time the spirals formed, suggesting the presence of a Q-barrier to wave propagation resulting from the bulge. The relative bulge mass in these cases is about 10%. Models with weak two-arm spirals had pattern speeds that followed the radial dependence of the Inner Lindblad Resonance.
Media Education as a Strategy for Online Civic Participation in Portuguese Schools
Authors: Dias-Fonseca Tânia , Potter John
Published: July 2016

Whilst various studies have examined participation on the Internet as a key element of a new emergent civic engagement, informally or formally through national and local governments’ online measures, less has been done to measure or suggest ways of overcoming social and technological constraints on online civic participation. Additionally, few studies have looked at the relationship between the actual implementation of such initiatives in classrooms and the messages which are conveyed indirectly as a result of teachers’ own conceptions of classroom strategies, which are perhaps better described as a “hidden curriculum”. This paper reports on these constructions through a set of detailed quantitative and qualitative case studies of the implementation of civic engagement through online activity in several regions of Portugal. The data, obtained through questionnaires, were used to produce novel composite scores reflecting the participatory and media literacy strategies of schools, as well as teachers and students’ media literacy and online civic actions. We present empirical results from a study population consisting of 12 public secondary school principals, 131 teachers, and 1,392 students in grades 11 and 12, suggesting that students’ online civic engagement and media literacy levels are affected by their teachers’ classroom practices and further training and by the implementation of a project-based approach to media education.

Mientras que numerosos estudios han examinado la participación en internet como elemento clave de una nueva involucración cívica emergente, informal o formal, a través de medidas gubernamentales locales o nacionales on-line, el esfuerzo ha sido menor para medir o sugerir formas de superar las restricciones sociales y tecnológicas de la participación cívica on-line. Pocos estudios se han centrado en la relación entre la implementación de las iniciativas en las aulas y los mensajes expresados indirectamente como resultado de las concepciones personales de los docentes en las estrategias didácticas que probablemente pueden ser descritas como «currículo oculto». Nos basamos en un análisis cuantitativo y cualitativo de un conjunto de estudios de casos sobre la implementación del compromiso cívico a través de actividades en línea en varias regiones de Portugal. Los datos obtenidos a través de cuestionarios fueron usados para crear un sistema de puntuación capaz de reflejar las estrategias escolares sobre la participación y la alfabetización mediática, así como, la acción cívica on-line de docentes y alumnos. Presentamos los resultados empíricos con una población que comprende 12 directores de escuelas públicas secundarias, 131 docentes y 1.392 alumnos de los cursos 11º y 12º. Los resultados sugieren que los niveles mediáticos de los estudiantes y sus niveles de compromiso cívico on-line están influenciados por las prácticas de sus profesores, su formación y por la implantación de proyectos de alfabetización mediática.
Media Competence of Teachers and Students of Compulsory Education in Spain
Authors: Ramírez-García Antonia , González-Fernández Natalia
Published: July 2016

Faced with a society that uses the media from dawn until dusk, it is imperative to identify the relationship between users and media. Therefore, this quantitative research aims to determine media competence levels of teachers and students in compulsory education in six areas. Media competence offers a diagnosis of possible shortcomings and needs educational intervention in both groups. Primary education students have shown an intermediate level of media competence. Secondary education students are at a basic level of competence in all the areas, except for technology and media literacy, which are at an intermediate level of competence. Most teachers have a basic level of media competence in all areas. Despite having a curriculum that meets the needs of media literacy in compulsory education and the proliferation of policies supporting technology, this is the weakest area in participants. A critical revision of school curricula and a consensus in their design and development would facilitate students’ shared training and minimize a possible exclusion in relation to media. Meanwhile an own curriculum and a training through a network of related professionals is the way to achieve higher levels of competence in both groups.

Ante una sociedad en la que desde el amanecer se utilizan medios de comunicación, es necesario identificar las relaciones que se establecen con los mismos. Esta investigación de naturaleza cuantitativa pretende determinar los niveles de competencia mediática del profesorado y alumnado de educación obligatoria en las seis dimensiones que la integran. Estos niveles ofrecen un primer diagnóstico sobre posibles carencias y necesidades de intervención educativa. El alumnado de Educación Primaria demostró poseer unos niveles competenciales medios. El alumnado de Educación Secundaria, salvo para las dimensiones tecnología y estética, que se situaría en un nivel medio de competencia, en las restantes, el porcentaje mayoritario lo sitúa en niveles básicos. La mayor parte del profesorado en todas las dimensiones de la competencia mediática se ubica en un nivel básico. A pesar de contar con un currículo escolar que responde a las necesidades de alfabetización mediática en la enseñanza obligatoria y proliferar políticas de apoyo a la tecnología, en la práctica la mayor debilidad de los participantes, sobre todo profesorado, se centra en el aspecto tecnológico. La revisión crítica de los currículos escolares y un consenso en el diseño y desarrollo de los mismos facilitarían una formación común del alumnado y alejaría el fantasma de una posible exclusión mediática. Mientras que un currículo propio y una formación mediante redes relacionales de profesionales es el camino para alcanzar mayores niveles competenciales en ambos colectivos.