bluuebunny/crossref_metadata_2025 huggingface dataset:
Fundamentos filosóficos y perspectivas actuales de un abordaje humeano al problema de las otras mentes
Authors: Guerrero Leandro
Published: November 2016

En este trabajo se explora el “problema de las otras mentes” desde una perspectiva humeana, con la intención de concebir una alternativa anticartesiana tanto en el nivel teórico como en el metateórico. Para ello, se examinan brevemente algunas de las características más importantes de la teoría humeana de la subjetividad, sistemáticamente desatendidas por la mayoría de los intérpretes: la preponderancia de la dimensión pasional (de raigambre intersubjetiva) en la formación gradual de la subjetividad y el papel de la simpatía en ese proceso. Además, se sostiene la posibilidad de elaborar una perspectiva anticartesiana sobre la base de una inversión metateórica ineludible, un verdadero giro práctico que tiene lugar dentro de la propuesta humeana, el cual implica hacer un marcado hincapié en la primacía del aspecto práctico-intersubjetivo de la subjetividad por encima del aspecto teórico-individualista.
Modos de articulación entre política y economía en el pensamiento de Aristóteles: divergencias con la hermenéutica arendtiana
Authors: Rossi Miguel Ángel , Borisonik Hernán , Mancinelli Elena
Published: November 2016

El objetivo de este artículo es reflexionar acerca de los modos en los que la política y la economía se articulan en la cosmovisión aristotélica. Para ello trabajaremos dos ejes temáticos. En primer lugar, la relación entreoíkos y polis y, en segundo lugar, la relación entre economía y los regímenes políticos. Uno de los aspectos nodales del trabajo gira en torno a mostrar nuestras diferencias con respecto a la hermenéutica de Arendt y, en tal sentido, el artículo hace énfasis en la importancia que también tiene para Aristóteles la dimensión económica para pensar la política, cuestión más que clara en el régimen que el Estagirita considera el mejor posible: la politeia.
Nancy, Badiou y Lacan: La composición compleja del concepto
Authors: Farrán Roque
Published: November 2016

En este artículo presentaremos primero dos discusiones muy puntuales que confrontan a Badiou con Nancy y Lacan en torno al vacío y al infinito. Mostraremos después cómo pensamos que se articula el concepto, tanto en filosofía como en psicoanálisis, a la luz de dichas complejidades y de las imbricadas relaciones entre los diversos dispositivos de pensamiento que ellas implican.
Las hijas del Sol en el proemio de Parménides
Authors: Berruecos Frank Bernardo
Published: November 2016

El presente trabajo esbozará ciertos elementos para una interpretación global del proemio de Parménides, a partir del análisis de uno de sus elementos centrales: las doncellas hijas del Sol. Tras examinar las acciones que éstas realizan dentro de la narración, y con el objetivo de defender una interpretación alegórica, se definirá la actividad alegórica arcaica mediante algunos ejemplos. Finalmente, se trazarán los cimientos para una revalorización crítica de la interpretación de Sexto Empírico y se argumentará que la alegoría platónica del carro alado como símbolo de la ψυχή en el Fedro bien podría estar recreando y evocando de cerca el mito parmenideo del proemio. La disyuntiva hermenéutica ( νάβασις-κατάβασις) se halla motivada por la ambigüedad intrínseca del relato, ambigüedad que tiene por objeto mostrar la unidad real de los contrarios aparentes a través del símbolo de las doncellas hijas del Sol
El Aporte de Jakob von Uexküll a Los conceptos fundamentales de la metafísica. Mundo, finitud, soledad (1929–1930) de Martin Heidegger
Authors: Muñoz Pérez Enrique V.
Published: November 2016

En este artículo sostengo que los planteamientos de Jakob von Uexküll constituyen un apoyo científico decisivo para las reflexiones metafísicas de Martin Heidegger sobre el mundo, más allá de lo que el mismo Heidegger reconoce explícitamente. En particular, los estudios de Jakob von Uexküll enfatizan, de mejor manera que el mecanicismo y el vitalismo, la relación que existe entre el medio ambiente y el mundo interior del animal, lo que es fundamental para que Heidegger sostenga en su lección de invierno de 1929 y 1930 que la esencia del animal es el “perturbamiento” (Benomenheit).
Latencia. La elaboración de la experiencia originaria
Authors: VILLACAÑAS BERLANGA José Luis
Published: November 2016

Este ensayo analiza el origen y la fundamentación del concepto de latencia en relación con los trabajos de Husserl acerca de la constitución originaria de la temporalidad. Intenta mostrar que el concepto de latencia, lejos de ser un concepto de la ontología, es ante todo un concepto de los sistemas temporales inteligentes. Como tal, despliega el ámbito de lo trascendental y prepara una comprensión más profunda de la noción de vida como uno de esos sistemas temporales. Así, la latencia es la manera en que la vida organiza su temporalidad, pues lo determinante de ella es la forma en que el pasado se activa ante la finitud de un presente dotado de sentido. La latencia es una condición trascendental de sentido. La consecuencia de esto es la imposibilidad de una comprensión de la vida completamente actualista, tal y como la entiende la ontología de Deleuze.

 

 
Invisibilidad e incomunicabilidad. Apuntes sobre el estatuto ontológico de la exclusión
Authors: CASUSO Gianfranco
Published: November 2016

Uno de los intentos más completos de aproximación al complejo inclusión/exclusión procede de la teoría de sistemas de Luhmann. En ésta pueden reconocerse al menos dos formas de entender el problema. Luego de analizar los puntos centrales de la concepción dualista que se halla en la base del modelo sistémico-funcional, en el presente artículo se defenderá la tesis de que Luhmann tiene que efectuar un cambio de perspectiva para abordar de modo más efectivo la problemática de la exclusión. Para ello se reconstruirán críticamente dos de los escritos centrales de su obra tardía y se mostrará cómo la segunda aproximación revela la dimensión ontológico-constitutiva de los procesos de diferenciación social con el fin de superar las contradicciones del dualismo funcionalista. De esto se concluirá que sólo esta dimensión permite explorar los posibles mecanismos que hacen explícito el lado oculto de la inclusión y muestran el papel de la experiencia de la exclusión como una perspectiva privilegiada para desafiar de modo inmanente los órdenes fácticos. 

 
Membaca Al Fatihah Reflektif Intuitif untuk Menurunkan Depresi dan Meningkatkan Imunitas
Authors: Julianto Very , Subandi -
Published: November 2016

This study aimed to reduce depression and increase immunity through training of reading of the reflective intuitive Al-Fatihah. Researchers used an experimental method with pretest-posttest control group design. Each experimental group and control group consisted of 10 students of Islamic Boarding School. To measure stress degree, Depression Anxiety Stress Scale (DASS) was used. Immunity was measured with microscopic slide method using hematology analyzer. Quantitative analysis was done through a mixed design anova statistical test. The results showed that the training could reduce depression (F=15.34, p
Peningkatan Interaksi Ibu dan Anak Retardasi Mental melalui Pelatihan Bermain Pura-Pura
Authors: Fithriya Suci , Lestari Sri
Published: November 2016

This study aimed to prove the influence of training of playing pretense game in increasing mother’s interaction with her mentally-retarded child. There were eight mothers who have under-five-year children with mental retardation participating in the research. They were randomly chosen. The research design used pre-test and post-test control group. Four mothers belonged to the control group and the other four to the treatment group. The training of playing pretense game with children was conducted in four stages. The first and second stages were done in group while the third and fourth were individual. Mother and child interaction scale was used to measure the differences of the interaction before and after the training. The follow-up research was done thirteen days after the training. The results showed the pretense game played by a mother and her mentally-retarded child can make their interaction become more meaningful.

Keywords: mother and mentally-retarded child interaction, pretense game training
Kinerja Karyawan Berdasarkan Keterbukaan terhadap Pengalaman, Organizational Citizenship Behavior dan Budaya Organisasi
Authors: Satwika Pratista Arya , Himam Fathul
Published: November 2016

Globalization era demands high organization’s performance to survive. There are some human resource problems in Indonesia that indirectly influence individuals’ performance in the organization. This research aimed to determine openness to experience, organiza¬tional citizenship behavior (OCB) and employee-oriented organizational culture as employee per-formance predictor. Ths was a field study that used a quantitative methodology. A questionnaire was used to collect data about open¬ness to experience, organizational citizenship behavior, employee-oriented organizational culture, and employee performance. Hypothesis test done with regression analysis toward 166 respondents resulted in the value of F=52,971 (p
Peran Faktor-faktor Psikologis terhadap Depresi pada Pasien Diabetes Mellitus Tipe 2
Authors: Donsu Jenita DT , Hadjam M Noor Rochman , Asdie Ahmad Husain , Hidayat Rahmat
Published: November 2016

Depression has strong relationship with diabetes mellitus and the aspect of psychology has influence toward the diabetes patient as control. This research aimed to find out the role of psychological factors in dealing with depression suffered by patient of DM-2 and to see the dynamics of both direct and indirect relationship of psychological factors toward the depression of DM-2 patient. The main model is a model that can bring effect of mediation between social support and depression caused by DM-2. Optimism can provide mediating effect of the relationship between social support and self-esteem. Resilience can provide mediating effect of the relationship between social support and self-esteem. Similarly, self-esteem acts as the mediator of the relationship between optimism and resilience toward the depression of DM-2 patient. The result of estimation parameter test showed the direct relationship between social support toward optimism (0.717), resilience (0.811), self-esteem (0.269) and depression (-0.210) and the direct role to depression (-0.397). The higher social support and self-esteem will cause the higher optimism and resilience. On the other hand, the role of self-esteem showed negative coefficient. On the other hand, the role of self-esteem to depression showed a negative coefficient is, the higher self-esteem will be followed by the decrease of depression in patient with DM-2.

Keywords: depression, optimism, resilience, self-esteem, social support, DM-2
Peningkatan Daya Saing Siswa Menengah Kejuruan Swasta melalui Pelatihan Regulasi Diri
Authors: Sakti Hastaning , Ariati Jati
Published: November 2016

The aim of this research was to design self-regulation training as an alternative effort to enhance students’ competitiveness. A total number of 147 students from two private vocational schools were involved as subjects. Pretest posttest control group design was used. In each school there were an experimental group, which got self-regulation training, and a control group, which got self-concept training. Manipulation was delivered six times each of which was supervised by two observers. T-test showed there were differences between experimental groups. SMK PL: before (M=89.93, SD=7.681) and after manipulation (M=92.16, SD=7.278) t(43) =-2.185, p
BEBERAPA ASPEK PENTING PADA PENYADAPAN PANEL ATAS TANAMAN KARET
Authors: Herlinawati Eva , Kuswanhadi Kuswanhadi
Published: November 2016

Secara konvensional, penyadapan panel atas dilakukan ketika kulit pada panel bawah sudah disadap selama 2 periode (perawan dan pilihan), pada ketinggian 130 cm ke atas hingga ketinggian 260 cm dari kaki gajah. Panel atas tanaman karet memiliki potensi yang besar dalam eksploitasi karet. Masalah utama dalam penyadapan panel atas adalah mutu sadapan yang kurang baik dan kehilangan produksi diperkirakan mencapai 30% sebagai akibat aliran lateks yang keluar dari alur sadap. Aspek teknis penyadapan seperti ketinggian, arah, kemiringan, dan  kedalaman sadap perlu diterapkan  untuk mengoptimalkan produksi lateks sekaligus meminimalkan pengaruh negatif terhadap kesehatan tanaman. Sadapan dengan irisan pendek (S/4) ke arah atas dikombinasikan dengan stimulan yang efektif diharapkan dapat mengoptimalkan produksi pada panel atas.
PERKEMBANGAN KULTUR IN VITRO PADA TANAMAN KARET (Hevea brasiliensis, Müell. Arg.) MELALUI EMBRIOGENESIS SOMATIK DI CIRAD PERANCIS
Authors: Bintarti Ari Fina
Published: November 2016

Embriogenesis somatik menjadi alternatif perbanyakan klonal pada tanaman karet untuk mendapatkan bahan tanam dengan sistem perakaran sendiri dan identik dengan induknya. Penelitian mengenai embriogenesis somatik pada tanaman karet sudah banyak dilakukan oleh lembaga penelitian di dunia, salah satunya adalah lembaga penelitian swasta CIRAD Perancis. Berbagai penelitian dalam upaya pengembangan metode embriogenesis somatik tanaman karet telah diteliti mulai tahun 1970-an, meliputi Embriogenesis Somatik Primer, Embriogenesis Somatik Jangka Panjang atau, dan Embriogenesis Somatik Sekunder. Selain itu, tim peneliti di CIRAD juga telah berhasil mengembangkan teknologi kriopreservasi atau penyimpanan jangka panjang di dalam nitrogen cair yang dikaitkan dengan Embriogenesis Somatic Sekunder untuk menyeleksi dan menetapkan galur-galur kalus yang mempunyai kapasitas embriogenik dan regenerasi tinggi. Walaupun begitu, teknik embriogenesis somatik belum bisa diaplikasikan secara luas untuk perbanyakan tanaman karet secara massal, karena beberapa kendala. Lebih jauh, teknik embriogenesis somatik dan kriopreservasi dapat mendukung program pemuliaan tanaman untuk menciptakan tanaman karet transgenik dengan sifat-sifat agronomis unggul seperti toleran terhadap stress abiotik dan produksi lateks tinggi.
Acellular matrix as a substrate for tissue-engineered graft of heart valve
Authors: Popandopulo A. , Petrova M.
Published: November 2016

In many cases heart valve prosthetics is the only solution to save patient’s life. All mechanical prosthetics currently used are not able to perform function in the body fully because non-living materials are used for their production. Tissue engineering provides the reconstruction of viable valves using stem cells. Acellularized three-dimensional tissue scaffolds as a matrix for autologous cells do improve function of heart valves and promote heart regeneration.
Why income inequality is so high in Serbia: Empirical evidence and a measurement of the key factors
Authors: Krstic Gorana
Published: November 2016

We analyse the extent and evolution of income inequality in Serbia and
examine factors that may have contributed to the high and rising inequality.
Specifically, using data from the 2013 Survey of Income and Living
Conditions, we focus on two issues: the effect of the quantity and quality of
household members? employment on the earnings of low-wage workers, and the
role of taxes and social transfers in redistributing income from the
betteroff to the poor. The results suggest that income inequality, measured
by the Gini coefficient, has significantly increased in Serbia over the
period of economic crisis, reaching 38.7 in 2013. The examined causes of such
a high inequality are the high rate of low work intensity of household
members and the high proportion of people working in non-standard forms of
employment (i.e., part-time, temporary, and self-employment arrangements),
mostly in the informal sector. In addition, the low coverage of social
transfers, particularly monetary social assistance and child benefits, and
the very low level of progressivity of the Serbian personal tax system
explain the relatively modest - by international standards - redistributive
role of direct taxes and social transfers.
Public debt sustainability in Serbia before and during the global financial crisis
Authors: Andric Vladimir , Arsic Milojko , Nojkovic Aleksandra
Published: November 2016

We have analyzed the behaviour of primary fiscal balance and public debt in
Serbia before and in the aftermath of the global financial crisis. The
results of our analysis are: i) public debt to GDP ratioexhibits (near) unit
root behaviour with an overall upward time trend; ii) the response of primary
fiscal balance to public debt has been insufficient to mean revert the upward
trend in government debt; iii) the efforts of the Serbian government to repay
the debt principal after the fiscal rule breach have not been persistent,
providing empirical support to the fiscal fatigue hypothesis; iv) the
government budget constraint has deteriorated since the beginning of the
global financial crisis; v) the response of primary fiscal balance to public
debt from the onset of the global financial crisis has dropped more severely
in comparison to other European economies.
Some notes on problematic issues in DSGE models
Authors: Slanicay Martin , Capek Jan , Hlousek Miroslav
Published: November 2016

We review some of the problematic issues in DSGE models, which are currently
much discussed in the economics profession. All of these issues are
concerned with the DSGE models? (in)ability to match aspects of
macroeconomic variables? observed behaviour. The optimizing agents framework
implies that Ricardian equivalence typically holds, which is clearly at odds
with the empirical evidence. A distinguishing feature of DSGE models is the
assumption that structural parameters are invariant to policy changes. We
argue that not all of them can be considered independent from economic
policy. It is typical for DSGE models that agents form rational
expectations, which can be considered unrealistic. The typical procedure for
estimating a DSGE model is to use revised data. As some empirical studies
suggest, a model?s behaviour may be different if real-time data are
considered. It is also usually assumed that the monetary authority uses the
interest rate as a tool of monetary policy. Nowadays, nominal interest rates
are close to zero in many economies and cannot be lowered further.
Seedling growth of maize (Zea mays L.) inbred lines affected by seed treatment with pesticides
Authors: Tamindzic Gordana , Nikolic Zorica , Savic Jasna , Milosevic Dragana , Petrovic Gordana , Ivanovic Dragana , Ignjatov Maja
Published: November 2016

Seed treatment is a common way of fungicide and insecticide use nowadays,
since this way of pesticide application can provide the best protection in
the vicinity of the future plant. The aim of research was to evaluate the
effects of different seed treatments on germination and seedling growth in
three maize inbred lines. The research included the seed treatment with
several combinations of a fungicide Maxim XL 035-FS (a.i. metalaxil-M +
fludioxonil) and neonicotinoid insecticides Gaucho 600-FS (a.i. imidacloprid)
and Cruiser 350-FS (a.i. thiamethoxam), as well as untreated seed (control).
The results indicated that inbred lines 21202 x 21101 NS and 317659 NS had a
highly vigourous seed which was not affected by the seed treatments. The seed
treatments with Maxim XL 035- FS+Gaucho 600-FS and Maxim XL 035-FS+Cruiser
350-FS led to a decrease in germination (90.25% and 89.50%, respectively) of
maize inbred line 306081 NS as well as a decrease in root length (126.75 mm
and 125.25 mm, respectively) and dry root weight (0.135 g and 0.1875 g,
respectively) of maize inbred line 21202 x 21101 NS. All seed treatments had
positive effects on root growth, as well as on fresh root weight of maize
inbred lines 306081 NS and 317659 NS.
Anthropometric characteristics and functional capacity of elite rowers and handball players
Authors: Karaba-Jakovljevic Dea , Jovanovic Gordana , Eric Mirela , Klasnja Aleksandar , Slavic Danijel , Lukac Damir
Published: November 2016

Introduction. Anthropometric and anaerobic profile of elite athletes are
fundamental for the assessment of their respective performance. The present
study was designed to evaluate the anthropometric parameters, body
composition and anaerobic characteristics of elite male handball players and
rowers, and to compare them in relation to specific sport demands. Material
and Methods. The study group consisted of 41 elite national level athletes:
20 handball players (aged 23.7?3.72) and 21 rowers (aged 19.7?2.84).
Anthropometric characteristics (body mass, body height, skinfold thickness,
body circumferences), and body fat mass were evaluated, and Wingate anaerobic
test for anaerobic power assessment was applied. Results. The significant
differences were noted in chest, upper arm, waist and hip circumferences, and
supraspinal and calf skinfolds between the two investigated groups. Rowers
showed higher values of fat body mass (13.2?3.76 vs. 10.7?3.76%), but lower
body mass index (22.0?1,92 vs. 25.7?2.31 kg/m2) compared to handball players.
When analyzing the Wingate test parameters, significantly higher values of
absolute anaerobic power (786?127 vs. 691?140 W), absolute explosive power in
the handball players compared to the rowers were recorded (118?26.3 vs.
105?27.8 W/s), while rowers achieved higher relative anaerobic capacity
(192?31.2 vs. 177?20.8 J/kg). Conclusion. Specific body composition and
anthropometrical assessment as a part of morphological analysis should
complement physiological profile of elite athletes. The analysis of the
anaerobic performance shows that the handball players have greater alactic
anaerobic and explosive power component, compared to the rowers in whom the
anaerobic endurance and specific training have the greatest effect on the
consumption of dominant metabolic substrate during the race.
Anaesthesia for awake brain tumour surgery: Case report
Authors: Vickovic Sanja , Ikonic Nada , Karan Vedrana , Karan Mladen , Vulekovic Petar
Published: November 2016

Introduction. There is an increasing trend towards performing awake
craniotomy procedures. The method is indicated for surgical treatment of
brain changes located in functional regions. This technique poses a unique
challenge for the anaesthesiologist in view of providing adequate sedation,
analgesia, hemodynamic and respiratory stability yet to keep the patient
awake and cooperative during the procedure. Case Report. After the adequate
preoperative preparation of the patient, the surgical procedure on tumorous
change in the left frontoparietal area (Broca?s area) was performed. Due to
the tumour localization, the surgical treatment was performed in awake
condition under intraoperative neurophysiological monitoring of the patient.
Analgosedation (Ramsay score 2-3) was provided via continuous infusion of
propofol and reminfentanil. Local infiltration anaesthesia (scalp block) was
preformed with levobupivacaine. The surgical procedure proceeded without any
major incidents and complications. Conclusion. A propofol/reminfentanil
combination provided safe and effective analgosedation of the patient.
Intermittent exotropia course in frontonasal dysplasia and severe orbital hypertelorism: Case report
Authors: Pavlovic Zorana , Stankovic Branislav
Published: November 2016

Introduction. Frontonasal dysplasia is a rare condition of congenital
structure malformations of the midface. Ophthalmologic abnormalities have
been estimated to occur in 87% of cases of frontonasal dysplasia. Case
Report. We report a case of type I frontonsal dysplasia in a 15-year old boy
after the correction of severe hypertelorism, median nasal cleft with a broad
nasal root and associated decompensated intermittent exotropia with
overaction of the inferior oblique muscles and V pattern. He underwent
bilateral lateral rectus recessions of 6.0 mm for intermittent exotropia when
he was six years old. The correction of hypertelorism was performed with
orbital rotation surgery when he was thirteen years old. For some time after
strabismus surgery, the ocular alignment improved, but it deteriorated
gradually. The ocular alignment improved after the hipertelorismus
correction; however, intermittent exotropia deteriorated gradually again six
to seven months later. On the last ophthalmologic examination, he had the
ocular alignment on the level of small angle exotropia and associated
hypertropia and occasionally even small angle esotropia at near. There was
bilateral overelevation in adduction and V pattern, which remained unchanged
after extensive facial bones surgical procedures. Conclusion. The high
incidence of ocular abnormalities, particularly exodeviations, indicates that
the early assessment by an ophthalmologist should be a part of the initial
evaluation of patients with frontonasal dysplasia to detect treatable visual
or ocular problems.
Specific features of anesthesia in patients with myasthenia gravis
Authors: Spasojevic Ivana , Hajdukovic Danica , Komarcevic Milena , Petrovic Stanislava , Jovanovic Jelena , Ciric Aleksandra
Published: November 2016

Introduction. Myasthenia gravis is an autoimmune disease caused by antibodies
leading to the destruction of nicotinic acetylcholine receptors on the
neuromuscular junction. It is characterized by muscle weakness that gets
aggravated with physical activity and improves at rest. Myasthenia Gravis
Foundation of America made the clinical classification of Myasthenia gravis
which is still in use today. ?Tensilon test? is still the gold standard for
the diagnosis of Myasthenia gravis. In addition to this test repeated
muscular stimulation can be used as well as the analysis of specific
autoantibodies. Treatment of Myasthenia Gravis. In conservative treatment of
Mysthenia gravis anticholinesterases, immunosuppressants and plasmapheresis
can be used. If conservative treatment does not lead to the desired
remission, surgical treatment is indicated. The most accepted indication for
thymectomy is the presence of thymoma with generalized form of Myasthenia
gravis in adults. How to Distinguish Myasthenic From Cholinergic Crisis. The
following is important to make a difference between these two crises:
knowledge of the events that preceded the crisis, the size of pupils as well
as the presence of muscarinic signs and tensilon test. Specific Features of
Anesthesia in Patients with Myasthenia Gravis. Mechanism of the disease
development is the reason for the increased sensitivity or resistance of
these patients to certain types of drugs used in anesthesia. Protocol of
Perioperative Anesthesia in Patients with Myasthenia Gravis. Based on 35
years of experience in the surgical treatment of patients with Myasthenia
gravis anesthesiologists at the Department of Thoracic Surgery, Institute for
Pulmonary Diseases of Vojvodina, made the protocol of anesthesia and
perioperative treatment for these patients. Conclusion. Anesthesiologists may
have to deal with a patient with myasthenia gravis in different types of
surgical interventions. The protocol for anesthesia and perioperative
management of these patients herewith presented may greatly help them in
their clinical practice.
Changes in linear and nonlinear measures of RR and QT interval series after beer intake
Authors: Platisa Mirjana , Gal Vera , Nestorovic Zorica , Leskosek-Cukalovic Ida , Despotovic Sasa , Veljovic Mile , Petrovic Aleksandar , Rajkovic Jovana , Djokic Vladimir , Novakovic Radmila , Gojkovic-Bukarica Ljiljana
Published: November 2016

Background/Aim. There are only several studies on the acute effect of alcoholic drinks intake on heart rhythm and this phenomenon is still not well understood. We wanted to examine whether linear and nonlinear measures of RR interval and QT interval series could quantify the effect of beer in healthy subjects. Methods. Eighteen young volunteers drank 500 mL of beer (21 g of ethanol). Electrocardiogram (ECG) recordings were taken in supine position: 20 minutes before (relaxation) and 60 minutes after drink intake. The RR interval series and the QT interval series were extracted from ECG and we calculated short-term (?1) and long-term (?2) scaling exponents and sample entropy (SampEn) for both series; low frequency (LF) and high frequency (HF) spectral components from RR interval series and QT variability (QTV). Blood pressure was measured every 10 minutes. Results. It was shown that beer induced changes in variability and correlation properties of these series. Immediate effect of beer intake was detected as a transient increase in the QT variability, heart rate and blood pressure. Delayed effects of beer were shortening of the RR and QT intervals and reduction of the HF spectral component. Beer intake also increased short-term scaling exponent (?1) of the RR time series and long-term scaling exponent (?2) of the QT time series. Conclusion. Our results suggest that acute effects of beer are reduced parasympathetic control of the heart and changed dynamic complexity of the ventricular repolarization.
Metformin Is Associated With Higher Relative Abundance of Mucin-Degrading Akkermansia muciniphila and Several Short-Chain Fatty Acid–Producing Microbiota in the Gut
Authors: de la Cuesta-Zuluaga Jacobo , Mueller Noel T. , Corrales-Agudelo Vanessa , Velásquez-Mejía Eliana P. , Carmona Jenny A. , Abad José M. , Escobar Juan S.
Published: November 2016

OBJECTIVE

Recent studies suggest the beneficial effects of metformin on glucose metabolism may be microbially mediated. We examined the association of type 2 diabetes, metformin, and gut microbiota in community-dwelling Colombian adults. On the basis of previous research, we hypothesized that metformin is associated with higher levels of short-chain fatty acid (SCFA)–producing and mucin-degrading microbiota.

RESEARCH DESIGN AND METHODS

Participants were selected from a larger cohort of 459 participants. The present analyses focus on the 28 participants diagnosed with diabetes—14 taking metformin— and the 84 participants without diabetes who were matched (3-to-1) to participants with diabetes by sex, age, and BMI. We measured demographic information, anthropometry, and blood biochemical parameters and collected fecal samples from which we performed 16S rRNA gene sequencing to analyze the composition and structure of the gut microbiota.

RESULTS

We found an association between diabetes and gut microbiota that was modified by metformin use. Compared with participants without diabetes, participants with diabetes taking metformin had higher relative abundance of Akkermansia muciniphila, a microbiota known for mucin degradation, and several gut microbiota known for production of SCFAs, including Butyrivibrio, Bifidobacterium bifidum, Megasphaera, and an operational taxonomic unit of Prevotella. In contrast, compared with participants without diabetes, participants with diabetes not taking metformin had higher relative abundance of Clostridiaceae 02d06 and a distinct operational taxonomic unit of Prevotella and a lower abundance of Enterococcus casseliflavus.

CONCLUSIONS

Our results support the hypothesis that metformin shifts gut microbiota composition through the enrichment of mucin-degrading A. muciniphila as well as several SCFA-producing microbiota. Future studies are needed to determine if these shifts mediate metformin’s glycemic and anti-inflammatory properties.
APP Mutations in Cerebral Amyloid Angiopathy with or without Cortical Calcifications: Report of Three Families and a Literature Review
Authors: Sellal François , Wallon David , Martinez-Almoyna Laurent , Marelli Cecilia , Dhar Abhinav , Oesterlé Héléne , Rovelet-Lecrux Anne , Rousseau Stéphane , Kourkoulis Christina E. , Rosand Jon , DiPucchio Zora Y. , Frosch Matthew , Gombert Claudine , Audoin Bertrand , Miné Manuèle , Riant Florence , Frebourg Thierry , Hannequin Didier , Campion Dominique , Greenberg Steven M. , Tournier-Lasserve Elisabeth , Nicolas Gaël
Published: November 2016

Background: Specific APP mutations cause cerebral amyloid angiopathy (CAA) with or without Alzheimer’s disease (AD).

Objective: We aimed at reporting APP mutations associated with CAA, describe the clinical, cerebrospinal fluid AD biomarkers, and neuroimaging features, and compare them with the data from the literature.

Methods: We performed a retrospective study in two French genetics laboratories by gathering all clinical and neuroimaging data from patients referred for a genetic diagnosis of CAA with an age of onset before 66 years and fulfilling the other Boston revised criteria. We studied the segregation of mutations in families and performed a comprehensive literature review of all cases reported with the same APP mutation.

Results: We screened APP in 61 unrelated French patients. Three mutations, located in the Aβ coding region, were detected in five patients from three families: p.Ala692Gly (Flemish), p.Glu693Lys (Italian), and p.Asp694Asn (Iowa). Patients exhibited CAA and progressive cognitive impairment associated with cortical calcifications in the Iowa and Italian mutation carriers, but not the patient carrying the Flemish mutation.

Conclusions: This is the first evidence of cortical calcification in patients with an APP mutation other than the Iowa mutation. We discuss the radiological, cerebrospinal fluid, and clinical phenotype of patients carrying these mutations in the literature.
Comparative theoretical study of Au1-3 and Cu1-3 clusters supported on SAPO-11 and their interactions with CO
Authors: Griffe Beulah , L. Brito Joaquín , Sierraalta Anibal
Published: November 2016

Quantum chemistry calculations were carried out using the ONIOM2 methodology at two different levels of calculation, B3LYP for the high level and UFF for the low level. These calculations were performed on aggregates to analyze the geometries of small clusters of Au1-3 and Cu1-3 supported on SAPO-11. Similarly CO-Au1-3/SAPO-11 and CO-Cu1-3/SAPO-11 moieties obtained by their interaction with CO, were calculated and the results of both cases are compared. The formation energy ΔEF of the metal aggregates and with CO adsorption, C-O and M-CO bond distances and calculated C=O stretching frequencies are reported.The most stable structures of the aggregates of Au1-3 and Cu1-3/SAPO-11 are similar, Au3 exhibits acute triangle geometry and Cu3 shows isosceles triangle with a large side geometry. The CO ΔEads values reveal that the CO adsorption is more stable in Au1-3/SAPO-11 than in Cu1-3/SAPO-11. Au-CO distances are larger than Cu-CO.
A genetic algorithm to solve 3D traveling salesman problem with initial population based on a GRASP algorithm
Authors: Meneses Sebastian , Cueva Rony , Tupia Manuel , Guanira Miguel
Published: November 2016

In this paper, the problem of obtaining optimal routes on tridimensional environments is discussed. This scenario is called as Traveler Salesman Problem (TSP 3D-variation). As is widely known, TSP has NP-complexity so is necessary to apply techniques to solve it approximately (no exacts solutions available). The purpose of this research is to present a genetic algorithm to solve 3D-TSP variation. These kind of evolutionary algorithms are ideal for solving complex problems where necessary rearrangements and route optimization. In case of genetic algorithms, optimal solutions appear faster depending on the quality of initial population, so theory recommends using metaheuristics for generating this population. In this study, it has used a metaheuristic GRASP algorithm to generate the initial population and, over it, apply the genetic operators proposed for optimizing individuals obtained. The results have optimal routes of movement and displacement and are directly applicable in the storage industry.
Heterogeneous system integration data integration guarantees
Authors: Olmsted Aspen
Published: November 2016

In this paper, I investigate the problem of providing guarantees for heterogeneous system integration. I propose a set of strong properties, FACD, which when held in the integration transaction will deliver correct results. The strong properties support an integration technique called CCETL(Continuous, Consistent, Extract, Translate, and Load). CCETL consumes UML class diagrams to identify transactional membership of the data elements that make up the integration. CCETL transforms the hierarchical relationships using a version of the topological sort. The sort maintains a navigation path from the original UML classes. The CCETL approach guarantees ACID properties up to the level of snapshot isolation between systems supporting a continuous integration.
Algorithms for ridge and valley detections in terrain maps
Authors: Koka Shinji , Anada Koichi , Yaku Takeo
Published: November 2016

We introduce ``the steepest ascent method'' and ``the steepest descent method'' to more effectively detects ridges and valleys in terrain maps, respectively. First, we propose algorithms by our methods. Next, we detect ridges and valleys in the entire Japan to compare our methods with the discrete Laplace transform method and show various advantages for our methods. And then, we claim that our algorithms can get sharper ridge and valley lines than the discrete Laplace transform method and makes it possible to generate terrain maps detected ridges and valleys in a huge area such as the entire Japan.
Formulations of patterns by a graph model for the game of Go
Authors: Sato Masafumi , Anada Koichi , Tsutsumi Masayoshi
Published: November 2016

The game of Go has a graph theoretical structure. Connected stones and enclosed regions are very worthful. On the other hand, we need to recalcurate groups of connected stones at each change of connectedness. BW Graph model gives us one of clear representations of features of positions with connectednesses and its recursions. By using recursions of positions, we can return from a given position to a previous position. In this paper, we focus on two moves, nakate and takefu. Nakate and takefu change connectednesses of intersections. We make static formulations of nakate and takefu moves by using the BW graph model.
The design and implementation of Multi-Maze
Authors: Liaw Heh-Tyan , Jou Chichang , Liou Ay-Hwa Andy , Debnath Narayan C.
Published: November 2016

Maze puzzle usually has only one user. This research has adopted network technology to develop a maze game, called Multi-Maze, which allows multiple players competing across the network concurrently. It contains three sub-systems. The Maze Editor is capable of building 3, 4, or 6 degrees multi-component maze and supporting automatic, semi-automatic, or manual construction of the maze. The contour of the maze can be configured freely and the process of building a maze is recorded for replaying. The Maze Runner supports single-user or multi-user mode. In multi-user mode, teammates communicate with multi-view display and real-time chats. Foot prints, marks, flags are used for avoiding repeated movements. The maze can be shown as wall or channel map. The Maze Manager allows editing, upload, download, and grouping of the teams. Before coding the Multi-Maze, two important utility tools have been developed: Multi-view Graph Library and Network Communication Module. Formulas for calculating the coordination for different degrees has been presented. Algorithms of spanning tree have been used for building a perfect maze. The adding and deleting of walls allow the maze to be separated into components and forming circuits. The state diagrams, data structures and class hierarchies are presented for related application projects.
Regular Exercise, Quality of Life, and Mobility in Parkinson’s Disease: A Longitudinal Analysis of National Parkinson Foundation Quality Improvement Initiative Data
Authors: Rafferty Miriam R. , Schmidt Peter N. , Luo Sheng T. , Li Kan , Marras Connie , Davis Thomas L. , Guttman Mark , Cubillos Fernando , Simuni Tanya ,   on behalf of all NPF-QII Investigators
Published: November 2016

Background: Research-based exercise interventions improve health-related quality of life (HRQL) and mobility in people with Parkinson’s disease (PD).

Objective: To examine whether exercise habits were associated with changes in HRQL and mobility over two years.

Methods: We identified a cohort of National Parkinson Foundation Quality Improvement Initiative (NPF-QII) participants with three visits. HRQL and mobility were measured with the Parkinson’s Disease Questionnaire (PDQ-39) and Timed Up and Go (TUG). We compared self-reported regular exercisers (≥2.5 hours/week) with people who did not exercise 2.5 hours/week. Then we quantified changes in HRQL and mobility associated with 30-minute increases in exercise, across PD severity, using mixed effects regression models.

Results: Participants with three observational study visits ( n = 3408) were younger, with milder PD, than participants with fewer visits. After 2 years, consistent exercisers and people who started to exercise regularly after their baseline visit had smaller declines in HRQL and mobility than non-exercisers ( p < 0.05). Non-exercisers worsened by 1.37 points on the PDQ-39 and a 0.47 seconds on the TUG per year. Increasing exercise by 30 minutes/week was associated with slower declines in HRQL (–0.16 points) and mobility (–0.04 sec). The benefit of exercise on HRQL was greater in advanced PD (–0.41 points) than mild PD (–0.14 points; p < 0.02).

Conclusions: Consistently exercising and starting regular exercise after baseline were associated with small but significant positive effects on HRQL and mobility changes over two years. The greater association of exercise with HRQL in advanced PD supports improving encouragement and facilitation of exercise in advanced PD.
Challenges of Improving Patient-Centred Care in Parkinson’s Disease
Authors: Mathur Soania , Mursaleen Leah , Stamford Jon , DeWitte Steve , Robledo Israel , Isaacs Tom
Published: November 2016

Background: Parkinson’s disease is a neurodegenerative condition with a complex pattern of motor and non-motor symptoms. Of several clinical scales used to measure patient experience few are delivered by patients themselves.

Objective: The present study reports the results of an online survey to establish (a) factors that most influence QoL (quality of life) for people with Parkinson’s and (b) areas where self-monitoring may help.

Methods: A 27 question online survey (using Survey Monkey) was developed by The Cure Parkinson’s Trust, comprising four main sections (demographics, monitoring, symptoms and communication).

Results: 492 patients participated. 97% felt it ‘very’ or ‘moderately’ important to understand their own Parkinson’s symptoms and recognise patterns in their condition ( n = 420). Although, 87% ( n = 467) were interested in recording information about their Parkinson’s to monitor their well-being, only 49% of respondents were actually doing so. Slowness of movement (82% n = 432) and lack of energy (61% n = 432) were the most reported motor and non-motor symptoms, respectively. These symptoms were also commonly reported to impact QoL ( n = 407). In monitoring these symptoms 75% ( n = 409) thought it would help improve their understanding of their condition, 64% thought it would improve their wellbeing and ability to cope, 61% thought it would improve their treatment and 59% thought it would improve communication with their healthcare team.

Conclusion: Collectively, the data suggest that a measurement tool supporting a patient-centred care model would be a combination of objective and accurate measurement of the most bothersome symptoms for patients towards the end goal of improving patients’ QoL.
Thin Film Williamson Nanofluid Flow with Varying Viscosity and Thermal Conductivity on a Time-Dependent Stretching Sheet
Authors: Khan Waris , Gul Taza , Idrees Muhammad , Islam Saeed , Khan Ilyas , Dennis L.C.C.
Published: November 2016

This article describes the effect of thermal radiation on the thin film nanofluid flow of a Williamson fluid over an unsteady stretching surface with variable fluid properties. The basic governing equations of continuity, momentum, energy, and concentration are incorporated. The effect of thermal radiation and viscous dissipation terms are included in the energy equation. The energy and concentration fields are also coupled with the effect of Dufour and Soret. The transformations are used to reduce the unsteady equations of velocity, temperature and concentration in the set of nonlinear differential equations and these equations are tackled through the Homotopy Analysis Method (HAM). For the sake of comparison, numerical (ND-Solve Method) solutions are also obtained. Special attention has been given to the variable fluid properties’ effects on the flow of a Williamson nanofluid. Finally, the effect of non-dimensional physical parameters like thermal conductivity, Schmidt number, Williamson parameter, Brinkman number, radiation parameter, and Prandtl number has been thoroughly demonstrated and discussed.
Numerical Study of Photoacoustic Pressure for Cancer Therapy
Authors: Grosges Thomas , Barchiesi Dominique
Published: November 2016

A commonly used therapy for cancer is based on the necrosis of cells induced by heating through the illumination of nanoparticles embedded in cells. Recently, the photoacoustic pressure shock induced by the illumination pulse was proved and this points to another means of cell destruction. The purpose of this study is to propose a model of the photoacoustic pressure in cells. The numerical resolution of the problem requires the accurate computation of the electromagnetism, the temperature and the pressure around the nanostructures embedded in a cell. Here, the problem of the interaction between an electromagnetic excitation and a gold nanoparticle embedded in a cell domain is solved. The variations of the thermal and photoacoustic pressures are studied in order to analyze the pressure shock wave inducing the collapse of the cell’s membrane in cancer therapy.
The Strategies to Homogenize PET/CT Metrics: The Case of Onco-Haematological Clinical Trials
Authors: Chauvie Stephane , Bergesio Fabrizio
Published: November 2016

Positron emission tomography (PET) has been a widely used tool in oncology for staging lymphomas for a long time. Recently, several large clinical trials demonstrated its utility in therapy management during treatment, paving the way to personalized medicine. In doing so, the traditional way of reporting PET based on the extent of disease has been complemented by a discrete scale that takes in account tumour metabolism. However, due to several technical, physical and biological limitations in the use of PET uptake as a biomarker, stringent rules have been used in clinical trials to reduce the errors in its evaluation. Within this manuscript we will describe shortly the evolution in PET reporting, examine the main errors in uptake measurement, and analyse which strategy the clinical trials applied to reduce them.
Development of a CA-FVM Model with Weakened Mesh Anisotropy and Application to Fe–C Alloy
Authors: Wang Weiling , Luo Sen , Zhu Miaoyong
Published: November 2016

In order to match the growth of the decentered square and the evolution of the interface cell in a two-dimensional cellular automaton-finite volume method (CA-FVM) model with decentered square algorithm, the present work first alters the determination of the half length of the square diagonal according to the preferential growth orientation, and then modifies the interface evolution considering the contribution of neighboring solid cells. Accordingly, the sharp interface (physical basis of the model), the growth orientation, and the growth consistence are reasonably guaranteed. The CA-FVM model presents some capabilities in predicting the free growth of equiaxed dendrites. With the increase of the cooling rate, the solidification structure gradually changes from cell to dendrite, and the solute segregation becomes more severe. Meanwhile, the predicted solute segregation under the intensive cooling condition is consistent with the calculation by Ueshima model at the initial solidification stage. The predicted competition behavior of columnar dendrites is qualitatively consistent with the observation in the continuously cast steel billet. The predicted dendrite arm spacings are close to the measurements.