bluuebunny/crossref_metadata_2025 huggingface dataset:
THE EFFECT OF RAW MATERIAL PRE MATURING ON PARENICA STEAMED CHEESE QUALITY
Authors: Čubon Juraj , Hascik Peter , Hleba LukÃ¡Å¡ , Cvikova Petronela , Pavelková Adriana , Capcarova Marcela , Císarová Miroslava , Ševelová Martina , Tkáčová Jana , Bobko Marek
Published: April 2019

The aim of the present study was to analyse the quality of the Parenica cheese (steamed shaped cheese) made of cheese aged one and three weeks. MDA (malondialdehyde) contents were similar in both Parenica cheese (0.32 mg.kg-1 resp. 0.30 mg.kg-1). Content of MDA was higher in the lump cheese-raw materials (0.44 resp. 0.59 mg.kg-1) than in the Parenica cheese (0.32 mg.kg-1 resp. 0.30 mg.kg-1). MDA content can be probably reduced in the processing to the hot water. The concentration of tyramine in the lump cheese on the 1st week of maturing was 1.37 mg.kg-1, and in the 3rd week of maturing increased to 4.48 mg.kg1. Tyramine content in the Parenica cheese made from lump cheese after 1st week of maturing was lower (0.49 mg.kg-1) than the lump cheese after 3rd week of maturing (2.47 mg.kg-1). The detected concentration of cadaverine was detected only in the lump cheese 3rd week of maturing (4.66 mg.kg-1) and in the Parenica cheese made from lump cheese after 3rd week of maturing (3.10 mg.kg-1). The sensory quality was performed by 5 points system. Parenica cheese made from lump cheese after 3rd week of maturing (4.91 points) in comparison with Parenica cheese made from lump cheese after 1st week of maturing (4.17 points). Overall acceptability was significantly higher for Parenica cheese made from lump cheese after 3rd week of maturing (4.83 points) in comparison with Parenica cheese made from lump cheese after 1st week of maturing (4.50 points). Higher sensorial quality of Parenica cheese made from lump cheese after 3rd week of maturing was caused by longer time of maturing. The longer time of maturing positively affected all sensory and physico-chemical parameters, but biogenic amines (mainly cadaverine and tyramine) content increased, because of maturing.
Az egynapos sebészeti ellátás igénybevételi mutatóinak elemzése Magyarországon
Authors: Pónusz Róbert , Endrei Dóra , Kovács Dalma , Németh Noémi , Schiszler Bence , Molics Bálint , Raposa László Bence , Gulácsi László , Gamal Eldin Mohamed , Boncz Imre
Published: April 2019

Abstract:

Introduction: The impact of one-day surgery has been increasing since the past few decades. This type of health service could fulfil many requirements of health policy, health care services, governments as well as patients. Aim: The aim of the research was to assess the publicly financed case numbers and interventions of one-day surgery in Hungary between 2010 and 2015 from different aspects. Method: A retrospective and quantitative research was made, based on data of the National Health Insurance Fund of Hungary. The database contained all publicly financed one-day surgery cases (both theoretical and performed cases), intervention codes (WHO) as well as the related medical field. Then the database also contained all relevant information related to the patients (age, sex, residency according to the county) and the type of the provider health care institutions. Results: Our results showed an increasing tendency according to the case numbers of one-day surgery from 130 995 (2010) to 251 328 (2015). The mean age of patients also increased in the analyzed period; in 2010: 47.4 years, in 2015: 54.5 years. In 2010, 42% of the theoretically defined one-day surgery cases were practically performed as one-day surgery cases which increased significantly to 65% in 2015. Gynecology, ophthalmology, general surgery and urology have had a significant impact in one-day surgery in Hungary. Conclusion: The analyzed data showed a significant increase of accounted cases, and we could identify the remarkable impact of gynecology and ophthalmology in one-day surgery in Hungary. Orv Hetil. 2019; 160(17): 670–678.
Az orális levodopakezelés jellegzetességei előrehaladott Parkinson-kórban a marosvásárhelyi neurológiai klinikák tapasztalatában
Authors: Szász József Attila , Szatmári Szabolcs , Constantin Viorelia , Mihály István , Rácz Attila , Domokos Lajos Csaba , Vajda Tamás , Orbán-Kis Károly
Published: April 2019

Abstract:

Introduction: The motor and non-motor complications of Parkinson’s disease impair the patients’ quality of life and limit therapeutical options. There are no clear criteria for ‘advanced’ Parkinson’s disease or for the optimal moment for invasive therapies. There is little evidence regarding the upper limits of levodopa doses, and how these may be influenced by the availability of device-aided therapies. Aim: To analyze substitution therapy in patients with advanced Parkinson’s disease. Method: In our retrospective study, we analyzed the data from all patients with advanced Parkinson’s disease hospitalized between 1st June 2011 and 31st May 2017, receiving combined levodopa treatment at least 4×/day, reporting a minimum of 2 hours off periods, with or without dyskinesia. We analyzed levodopa therapy for patients who were recommended either device-aided or conservative therapy. Results: Out of 311 patients with advanced Parkinson’s disease, for 125 we proposed device-aided therapies whereas in 42 patients we increased the levodopa dose. The average levodopa doses and the administration rate were higher for the 107 patients tested for levodopa-carbidopa intestinal gel. Disease duration, mean levodopa doses and frequency of dosing were all higher in patients proposed for device-aided therapies versus patients with continued conservative treatment. Conclusion: Our patients were on lower levodopa doses (compared to literature), but the combinations were used more often. Device-aided therapies should be considered in patients with severe motor complications who receive at least 750–1000 mg levodopa daily, divided minimum 5×/day. These patients need to be tested in specialized centers by multidisciplinary teams in order to make the best decision for further action. Orv Hetil. 2019; 160(17): 662–669.
Ethno-Cultural Influences on Multimodal Text Perception
Authors: Nikolskaya Tatiana , Pavlina Svetlana
Published: April 2019

The article investigates inter-cultural artistic communication which occurs through multimodal texts in general and feature films in particular. Artistic communication faces a challenge when its source and target belong to different ethnic and/or generational cohorts. The similarity or difference of communication codes depends on the level of adequacy of the sender's and the recipient's discursive competences. Discursive competences imply the ability to provide an adequate interpretation of situations depicted in the film, it is based on the knowledge and understanding of cultural, social and historical peculiarities of the society to which the creator belongs and which he or she depicts in the film. If the recipients ignore one of the semiotic systems incorporated in the multimodal text, the complete comprehension of the artistic text message can become unattainable. The authors conduct comparative analysis of how the Russian film "Moscow Does Not Believe in Tears" is perceived by Russian and American college 'Gen Z' students. In case the culture codes of the work of art contradict some rules and codes ingrained in the society to which the recipient belongs, the interpretation of the author's message can be hindered, which entails the artistic communication disruption. The analysis yields factors that determine the interpretation of an artistic message. The authors find that the differences in ethno-cultural backgrounds present a greater obstacle to the creator's artistic message successful decoding than a generation gap between the creator and the recipients.
The Mechanisms of Proversion and Reversion in Producing the Compounds of the English Language
Authors: Chekulay Igor , Prokhorova Olga , Kuchmistyy Vladislav
Published: April 2019

The subject-matter of this paper is the structural mechanism of the proverse and reverse word-compounding as a word-building process in modern English while having the model of word-combination as a starting basis for such transformations. The mechanism of proversion represents the process transforming a word-combination into a compound word while preserving the initial order of components coinciding with that of a word-combination (A + B → AB). When the reverse process of compounding takes place, the components of a resulting compound word change their places as to each other in comparison with a component-order in an initial word-combination (A + B → BA). The hypothesis of the investigation is that the compounding by proversion occurs if words of an initial word-combination are tied with the syntactic relation of agreement, while the reverse compounding usually tends to provide compounding on the basis of the syntactic relation of control. The proversive model is mostly the basis for creating nominative parts of speech, and the result of the reverse intergration of a word-combination into a compound word is manifested mainly by a verb or a verbal. The article describes the general and certain specific models of proverse and reverse compounding with the indication of their functional and stylistic peculiar features. The conclusion indicates the perspectives of working out the problem on the basis of other languages and on the comparative ground.
Semantic Categories in Ideographic Dictionaries
Authors: Vinogradov Sergey
Published: April 2019

The paper considers semantic categories presented in the ideographic discourse. Research material includes the information retrieval thesauruses reflecting scientific information activities and functional and ideographic dictionaries representing the discourse of training in writing school compositions and the epistolary discourse (letters of Russian writers). The author regards semantic categories as sign units (sign formations) whose content plane is general concepts, and denotation is various language (sign) means forming this general concepts. The article shows that semantic categories, as the result of categorization, reflect properties of the discourse - the functional and communicative field in which it appears, characteristics of the speech subject, character of the relation of the author of the text to its topic and to the addressee, interaction with the language code. The paper discusses the technique of semantic category choice, the formation of their list, their participation in creating the classification schemes of concepts, the opportunities of using ideographic dictionaries to solve linguistic and pedagogical tasks. The article provides the conclusions on the existence and nature of system communications of ideographic semantic categories with such cognitive aspects of the language as a problem situation in word using and understanding, classification of lexical units and concepts, psychology of thinking in language forms, specifics of extralinguistic factors in scientific and language activity in different private discourses.
Study of crack resistance of asphalt concrete pavements of the streets of the city of Bryansk and roads of the Bryansk region
Authors: Levkovich Tatiana , Mevlidinov Zelgedin , Rodin Pavel , Feshchenko Maxim
Published: April 2019

Asphalt concrete is the main type of coating the streets of the city of Bryansk and other cities of the Bryansk region, as well as roads outside settlements. A survey of the condition of asphalt concrete pavement of the streets of Bryansk and some parts of roads of other cities of the Bryansk region (streets of Surazh, Klintsy, Unecha, etc.) showed that in many areas there are surface destruction in the form of cracks: transverse, longitudinal and «grid». The presence of a crack in the coating of the road-reducing the load – bearing capacity of the road structure at the place of its formation.

The crack resistance of asphalt concrete decreases during the operation of the coating due to a number of reasons: deterioration of the properties and structure of asphalt concrete under the influence of internal and external factors (water, freezing-thawing, air oxygen, ultraviolet and infrared irradiation, the nature and degree of interaction of bitumen with mineral material, the structure and composition of bitumen, etc.), low-temperature stretching, aging of the binder, etc.

The authors of these studies set the task to check the quality of the properties of bitumen BND 60/90 and BND 90/130 with the introduction of polymer additives, carbon black, etc., as well as asphalt concrete mixtures with the introduction of polystyrene and polyurethane foam and other additives in the construction of road surfaces in hot summer climatic conditions to increase the crack resistance of asphalt concrete coatings.

The paper presents an analysis of the main parameters of transverse cracks in the city of Bryansk on the streets: Fokina, Sovietskaja, Gorbatova, Krahmaleva, as well as road surfaces of the Bryansk region.
Use of damp organomineralny mix for the device of constructive layers of road clothes when building road approach to Kerchensky Bridge from Tamani
Authors: Katasonov Maksim , Leskin Andrey , Kochetkov Andrey , Gofman Dmitriy , Kuxhausen Vladimir
Published: April 2019

One of ways of the device of the lower layers of road clothes of hot and cold asphalt concrete mixes is application the «organomineralnykh» of mixes. Results of optimum selection of damp mix (VOMS) on local inert materials (crushed-stone sandy mix) are presented. Application of VOMS gives big advantages in comparison with asphalt concrete mixes at the device of the bases and coverings of road clothes. It is the big range of working temperature that isn’t unimportant in northern areas. Besides labor input of production and the device of layers of VOMS is one many less that also positively influences economic expenses.

The big list of inert materials, available to application, at production of VOMS gives the chance of use of also local materials at construction that is confirmed on the example of Krasnodar Krai, where many such mixes as ShchGPS, ShchPS, GPS and in smaller volume granite materials that is also economic as reduces time on delivery of materials. As the knitting the bituminous emulsion of the cationic EBK-3 type in compliance of GOST P52128-2003 was applied медленнораспадающиеся. VOMS prepares in installation conveyor-based.
The system of normative documents in construction in the People’s Republic of China
Authors: Ovchinnikov Ilya , Chen Tao , Ovchinnikov Igor , Valiyev Sherali
Published: April 2019

The article notes that China has become a leading bridge-building power, implementing a program of their 10 steps aimed at maintaining economic growth. In this program, including such steps: the development of transport infrastructure: the expansion of the transport network through the construction of high-speed rail and toll roads, as well as airports, sea and river ports; the construction of a road network serving rural areas and coal mines; development of rural infrastructure: construction of roads and electric networks in rural areas; development of industry: introduction of innovations, industrial restructuring, support for the development of high-tech industries.

Further in the article the brief history of development of normative documents in China is resulted. First, China’s norms were guided by the norms of the Soviet Union, but then their norms began to be developed. Now in China there are national standards, professional (core) standards and local standards. Also, the standards are divided into mandatory and recommendatory. China’s system of engineering standards is divided into 24 regions. For example, standards for the design of railways include 33 volumes, of which the national standard is 1 volume. They take into account, as projects of linear structures, and long tunnels, bridges, change of geological conditions.
Issues of technical regulation in the Penza agglomeration of the Federal project "Safe and qualitative roads"
Authors: Bazhanov Anatoly , Saksonova Elena , Kochetkov Andrey , Shchegoleva Natalya
Published: April 2019

The article outlines the problems of implementing the program for the integrated development of the transport infrastructure of the Penza agglomeration aimed at bringing its street-road network into compliance with the requirements of the Technical Regulations of the Customs Union of TR CU 014/2011 «Road Safety». The authors established the absence of a normative document regulating the attribution of the street-road network of the Penza agglomeration to the concept of «streets of settlements», which are not subject to the technical regulations of TR TS 014/2011, which is classified as non-compliance with its requirements. In order to overcome the current legal and regulatory situation, the authors justified the need to develop methodological recommendations that include terminology, new principles of technical regulation, a systematic analysis of methodological documents used in the Penza agglomeration and economically viable proposals to bring normative support for road activity on its territory in line with requirements ТР TC 014/2011, as well as the positive experience of applying the evidence base of this technical regulation The structure of the developed document is proposed, which provides for the use of terminology and classification concepts for the objects of the Penza agglomeration street network, which do not fall within the scope of TR TS 014/2011, the law enforcement analysis and the selection of conformity checking schemes that do not require the use of a certain list of works and requirements of the regulatory documents of the Federal Service for accreditation, the order of interaction between the testing laboratory or the center and the customer, the choice of voluntary certification systems that can Carrying out the system analysis of the current normative base for road construction of the Penza agglomeration will ensure effective effective use of international agreements of the Russian Federation and federal legislation in the field of technical regulation and conformity checking on the street network of the Penza agglomeration.
Ensuring the shear resistance of asphalt mixtures in the pavement of highways
Authors: Mevlidinov Zelgedin , Levkovich Tatiana , Bilсko Anastasia
Published: April 2019

Studying the state of the issue on the shear resistance of asphalt concrete mixtures in the pavement, the authors reviewed the currently available technical reference literature. The state of the streets of the city of Bryansk and the highways of the Bryansk region by measuring the depth of the tracks and flows was also examined.

The asphalt concrete samples were tested in laboratory conditions taking into account the rate of deformation, temperature and stress-strain state using the device manufactured at the Department of «Highways» of the Bryansk state engineering and technological University. As additives in asphalt concrete mix introduced: rubber crumb from used car tyres, wheels automobiles, carbon black (powder form) and definiltely thermoplastics.

The conducted researches on samples of asphalt concrete mix with use of divinyl-styrene thermoplastics (DST) showed that at increase in the polymer content from 2 to 5 % there was some increase in durability of asphalt concrete on tension in 1,06…1,16 times at 0 °C (smaller value corresponds to the smaller number of DST). Compressive strength at a temperature of «plus» 50 °C increased by 1.04…1.08 times and the module of residual deformation at «plus» 50 °C increased by 1.18…1.23 times. In General, with an increase in the content of DST from 2 to 5 %, the shear resistance increased almost 1.27 times (with the introduction of 5 % DST over the mass of bitumen).

The conducted research allows to conclude that to reduce the impact of shear stresses in asphalt concrete mixtures it is necessary to introduce modifying additives, the properties of asphalt concrete depend on the presence of additives, as well as on the quality of the stone aggregate, bitumen and other materials. With the introduction of certain additives (DST, carbon black, rubber c hips), the shear resistance of asphalt concrete increases.
Oil and gas sector of Perm Krai: the actual status and prospects for development
Authors: Stepanenko Ivan , Karpovich Julia
Published: April 2019

The oil and gas industry of Perm Krai is one of the core industries that determines the actual status and prospects for the social and economic development of the region. This article assesses the impact of the oil and gas industry on the social and economic development of Perm Krai. The author comes to the conclusion that the industrial production, and in particular the oil and gas complex, remains the basic economy sector of Perm Krai, which plays a leading role in income generation of the territorial budget. On the basis of the oil and gas industry it is possible to develop the accompanying sectors in the economy. In other words, it can become a locomotive for developing other economy branches. Trends in the oil industry development in the Perm Krai coincide with those typical for the Russian Federation as a whole. Therefore, the sanction measures could not fail to have an impact on the economy of Perm Krai in general and the activities of the oil industry enterprises in particular. The action of economic sanctions led to a reduction in oil extraction, accompanied by a price drop; volumes of export; the limitation of supplies of specialized equipment and technologies for the developing oil deposits and oil production. To overcome this situation in the Perm Krai, the following measures can be proposed: creation of the new competitive capacities (which requires the additional investment sources) and creation of a petrochemical cluster.
Analysis and assessment of the risk of loss of stability of the car at the radius of the round-off of the Congress to determine the speed
Authors: Kochetkov Andrey , Shchegoleva Natal’ya , Zadvornov Vitaliy , Kochetkov Vladimir , Shashkov Igor
Published: April 2019

When applying innovations or repeated effective technical solutions of the road sector, it is recommended to use the risk of damage assessment in the project documentation. This gives an opportunity for expert organizations reasonably give a positive conclusion on the project documentation. The method of calculating the risk of harm in the design of the junction to the road, taking into account the basic works of V.V. Stolyarov.

A typical example of the study based on the assessment and calculation of the risk of harm is considered. The study is carried out taking into account the Federal law «on technical regulation» and article 15, paragraph 6 of the Federal law «Technical regulations on the safety of buildings and structures» based on the assessment of the risk of failure to achieve the goals and requirements of the Federal law. The probability-theoretical approach, in particular the risk theory, allows to increase safety, comfort and convenience of movement by changing the geometric and transport and operational indicators of roads.

The parameters of the curve (radius of curve), the coefficient of adhesion, and the longitudinal slope affect the probability of the car’s stability loss on the radius of the carriageway rounding associated with the car skidding or tilting. This procedure is designed to determine and reduce to the acceptable risk the probability of occurrence of road transport facilities due to imperfections of road conditions (rounding parameters).

Technical regulation, risk assessment, damage assessment, risk theory, operations, life cycle, quality management, standards, probability approach, road management.
Stability of unsaturated soil slopes covered with Melastoma malabathricum in Singapore
Authors: Satyanaga Alfrendo , Rahardjo Harianto
Published: April 2019

Past studies have shown that slopes covered with vegetation are less susceptible to rainfall-induced slope failures. This research was focused on the unsaturated properties of soil consisting of mangrove roots and their effects on the stability of an old alluvium soil slope during rainfall. Melastoma malabathricum was selected in this study since this mangrove is best suited for tropical climatic conditions. The results of laboratory tests indicated that the air-entry value and shear strength of soil with roots of M. malabathricum were higher than those of the soil without roots. The saturated permeability of the soil with roots was lower than that of the soil without roots. Numerical analyses indicated that the slope without M. malabathricum experienced significant decreases in the factor of safety during rainfall than the slope covered with M. malabathricum. M. malabathricum can thus be used as a vegetative cover for minimising rainwater infiltration in slope layers with a slope angle up to 35°.
Calibration of PET strap pullout models using a statistical approach
Authors: Miyata Y. , Bathurst R. J. , Allen T. M.
Published: April 2019

Polyester (PET) straps are being used more frequently in mechanically stabilized earth (MSE) walls. At present, there is no consensus on a model or models that are suitable for design codes to calculate the pullout capacity of these materials. A database of 296 pullout tests from 81 test series with single and closely-spaced parallel double PET strap configurations was collected by the writers. The data were taken from laboratory and in situ pullout tests. Existing linear and bi-linear pullout models for geosynthetic and steel strip reinforcement were investigated as candidate models and then empirically modified to improve pullout capacity predictions for both single and double PET strap arrangements. A non-linear exponential model with the same number of empirical coefficients was also investigated. The accuracy of each model was assessed quantitatively using bias analysis where bias is the ratio of measured to predicted capacity. The paper shows that non-linear models performed best based on mean and coefficient of variation (COV) of bias values and bias dependency with predicted pullout capacity and magnitude of vertical stress acting on the pullout length. The models investigated in this study are useful for pullout limit state calculations using both deterministic and reliability-based analysis and design approaches.
Dynamic tensile failure of Laurentian granite subjected to triaxial confinement
Authors: Wang Q. , Wu B. , Guo Y.
Published: April 2019

In this paper, a traditional split Hopkinson pressure bar system is modified to be able to conduct dynamic tests on rock specimens under triaxial stress conditions. Granite specimens are manufactured as Brazilian discs to examine the dynamic tensile failure of rocks, and to investigate the influence of the triaxial stress state and loading rate on the dynamic tensile strength of rocks. The experimental results reveal the rate-dependence phenomenon of the tensile strength. The effect of the triaxial stress state is divided into the influence of the hydrostatic stress and that of the pre-tension, and it is found that the dynamic tensile strength of rocks is almost independent on the pre-tension. An empirical equation is proposed to explain the dynamic tensile behaviour of rocks under triaxial stress state and it agrees well with the experimental results. This finding has a certain value for underground excavation that only the hydrostatic pressure needs to be considered to evaluate the dynamic tensile failure of rocks in the intermediate zone.
Instability of loose dry granular slopes observed in centrifuge tilting table tests
Authors: Wolinsky E. , Take W. A.
Published: April 2019

Landslides in loose saturated granular materials can experience significant deviatoric strain softening leading to static liquefaction and flow failure. This research study aimed at understanding the instability conditions leading to softening has been conducted under triaxial or plane strain conditions on loose granular soils brought to failure under undrained or drained stress paths. In this paper, it is hypothesised that the onset of granular instability should also be reproducible in tilt-table tests of loose dry granular soils. A centrifuge tilt-table apparatus was developed to test this hypothesis in which the stress path imposed on the soil layer could be inferred from an infinite slope analysis and the shear and volumetric strain be measured through the transparent side walls. Experiments performed at 1g, 20g, 40g and 60g illustrate that this approach can capture the constitutive behaviour of the soil layer. Critically, as the tilt-table test is a load-control test, instability was observed as a rapid acceleration in shear strain rate accompanied by a rapid volumetric collapse of the pore space. The tilt-table test therefore not only enables a measurement of the angle of repose, but provides a method to characterise the instability behaviour of granular materials at low stress levels found in shallow landslides.
Electrokinetic treatment of desiccated expansive clay
Authors: Hamza Omar , Ikin Jamie
Published: April 2019

Structures built on shallow foundations in expansive clay, where vegetation and weather conditions can significantly reduce the moisture content, must overcome the risk associated with excessive desiccation conditions, such as shrinkage and settlement. For many existing structures, removal of trees may not necessarily be an effective solution, as it can cause swelling and heave in the long term. This study explores a system that could be operated during prolonged drought periods to rehydrate and neutralise the negative pore pressures of expansive clay, avoiding the development of excessive desiccation. Electrokinetics is a proven method that has increasingly been adopted for dewatering and consolidation of fine-grained soils. The hypothesis presented is to reverse the electrokinetics process by extracting water from a saturated stratum below the groundwater level and force it into the ‘early-stage’ desiccated area, accelerating rehydration and reducing suction. The theory was examined by a laboratory model using moderately expansive clay. After draining the soil for 23 days to reach a moderate desiccation state, water was allowed into the lower part of the soil while applying the EK treatment using nine electrodes, placed in a radial pattern and inserted 110 mm into the soil with approximately 30% of their lengths below the water level. As a result of the electro-osmotic process, the average moisture content increased in the model by more than two-fold within 8 h. The suction measurement (taken in the middle of the desiccated area) showed an initial slow response followed by fast and consistent reduction rate, where suction dropped by 93% within 5 h and ultimately down to 1 kPa at the end of the treatment. This paper offers some insight into the factors controlling the proposed system and provides a good basis for future research to manage the risks associated with desiccation of expansive soils.
Using agent-based modelling to probe inclusive transport building design in practice
Authors: Harding John
Published: April 2019

Subtle differences between universal design (UD) and inclusive design (ID) discourses impact inclusivity in practice. The level of service (LOS) is used as a proxy to evaluate inclusivity and agent-based modelling is used as a research instrument to probe how circulation and high levels of crowdedness impact inclusivity within a digital model of an underground transport building. Case 1 integrates ‘first-generation’ design methods and UD aims underpinned by social-model-of-disability discourses. Case 2 integrates ‘next, next generation’ design, vertical severance, service design and ID aims underpinned by socio-material-interactional discourses. While case 1 produced unsatisfactory results for inclusivity, case 2 increased the LOS and inclusivity throughout, and within the vertical circulation by five-fold, without increasing the overall cost or size of the building. Consequently, case 2 identifies how new ID guidelines, evaluation techniques and methods could enable inclusivity in practice.
02: Parsing FASTA files v3
Authors: O Aylward Frank
Published: April 2019

Week 1 Introduction to parsing FASTA files. Commands to be entered into the command line are in bold. Here we will be using various base Unix commands such as head, tail, sort, wget, and others. We will also be using the seqkit tool to process FASTA files. The main page for seqkit is here: https://github.com/shenwei356/seqkit
Predatory Journals as a Threat to Science, Scientific Communication, and Author’s Reputation
Authors: Fiialka Svitlana
Published: April 2019

In the study, the features of predatory journals are highlighted; the threats from them for science, scientific communication and authors have been identified.

Methodology. To find out the reasons for which authors are published in predatory journals, we have selected 30 journals from various fields of knowledge included in the Bill`s list. Then, 200 articles, published in these journals, were selected by the method of simple random selection using the random number generator. The authors of the articles were sent a Google form for the survey. As a result, responses from 148 respondents were received and processed. Due to the analytical method, the invitations to publication received by the author of this article during the period from September 2018 to February 2019 were investigated, and thus the signs of predatory journals were summarized: multidisciplinarity of the journal, urgent publication of the article, distribution of spam messages, no review, publication of articles without any changes, discounts system for repeat publications, errors on the site of the journal, sending a review together with the article, the discrepancy of the editorial board with the subject matter of the articles, the lack of quotations of articles included to international scientometric databases.

Results. The poll revealed reasons for publishing in the predatory journals: pressure of leadership, uncertainty, low level of English, low level of financial support, ignorance of research methodology, as well as the prejudice of the reputable journals to the scientific results achieved by scientists from certain countries. The proliferation of predatory journals is a significant threat to science, scientific communication, and authors. Such journals discredit scientific knowledge, because lack of evaluation can lead to conscious violation of the rules of academic integrity, including plagiarism, data tampering and image manipulation, and therefore to promote the dissemination of pseudo-science, unjustified theories. These publications exist mostly due to the low scientific level of publication and destroy the reputation of the authors and institutions in which they work. To factors that influence why some Ukrainian scientists choose the predatory journals for publication of articles, are normative-legal and material-technical.
BLOCKCHAIN: THE ESSENCE OF TECHNOLOGY AND THE WAYS OF ITS APPLICATION IN THE FIELD OF CUSTOMS
Authors: Torukalo Y. E. , Yurieva I, G. , Makrusev V. V.
Published: April 2019

In the context of modern customs administration, new trends are emerging that need to be implemented. Today, one of the important and internationally recognized technologies is blockchain. The article deals with the main directions of its development, the principle of operation, the possible use in the system of customs authorities, as well as the prospects for its development.
MARKETING AND MANAGEMENT IN THE DIGITAL ECONOMY LANDSCAPE
Authors: Boltenkov D. V.
Published: April 2019

In the conditions of the emerging digital economy, it is necessary to form a more efficient and effective communication system between the enterprise and consumers. Companies that have not attached particular importance to the development of information and communication technologies and their use, it is becoming increasingly difficult to compete with industry leaders. These new modern processes in development allow us to speak about a fundamentally new stage in the development of society, far removed from the industrial stage of development. The purpose of the study is to identify the specifics of the development of marketing and management in the era of the digital economy. In the work were applied such methods of scientific knowledge, as a comparative analysis, generalization, systematization, historical and logical method. The article identifies the most significant trends in marketing and management and their implications for business entities.
Evaluation of clinical efficacy and safety of natural micronized progesterone in prevention of preterm labor: a prospective study at tertiary care teaching hospital in India
Authors: Patel Suhani V. , Gowani Shahnoor K. , Shah Sushma R. , Malhotra Supriya D.
Published: April 2019

Background: Uterine relaxants (UR) are used in management of in Preterm labour (PTL), which is responsible for considerable morbidity and mortality in mother as well as preterm infant. Author are yet to discover an ideal UR which is highly effective yet safe. Literature supports the use of natural micronized progesterone (NP) during threatened PTL. However, little data exists for Indian population. Therefore, present study becomes imperative.Methods: A comparative clinical study was carried out on 78 patients (aged 19 to 35 years with singleton pregnancy and gestational age between 28 and 37 weeks with cervix ≤4 cm dilated) who were diagnosed with threatened PTL were included. Those who refused treatment were allocated to control group (n= 29) and received only bed rest. NP was given orally 200 mg twice a day to 21 patients and 200 mg intra vaginal twice a day to 28 patients and was continued until delivery or 37 weeks of gestation whichever occurred first. The efficacy was proven if PTL was prevented and patient did not require an alternative UR for ≥48 hours.Results: The mean age of patients was 23±3.2 years, majority being multipara. Author observed that both oral and vaginal formulation of NP was found to be highly effective (p <0.05) as primary UR and maintenance therapy in preventing PTL as compared to the control group. However, difference between them was not statistically significant. None of the patients were lost to follow-up and no adverse events linked to the treatment were reported.Conclusions: Although, the data obtained from this study was limited and the sample size was small, findings of this study support the use of NP in prolonging threatened PTL.
Biosimilar etanercept: a real world safety and patient related outcomes from a single centre
Authors: Rath Prasan Deep , Pandey Swetal Chandraprakash
Published: April 2019

Background: Biosimilars are expected to provide affordable and quality treatment equivalent to the biologics in various rheumatic disorders. Presently, the data available on the safety and effectiveness of biosimilars is very scarce. The objective of the present study was to assess the safety profile of intended biosimilar of etanercept developed by Intas pharmaceuticals Ltd. (Intacept) in Rheumatoid arthritis (RA), spondyloarthropathy (SpA), ankylosing Spondylitis (AS), juvenile idiopathic arthritis (JIA) and psoriatic arthritis (PsA).Methods: In single center, retrospective observational study, all patients were enrolled in routine clinical practice     who received Intended biosimilar of Etanercept (Intacept) and the following data was collected. Basic demographic profile, disease and duration of therapy, any adverse event, patient’s global assessment of disease activity on visual analogue scale (0 to 100), patient’s overall experience with Intended biosimilar etanercept (Intacept).Results: Total 70 patients were enrolled (41males and 29 females) having RA (42), AS (11), SpA (13), JIA (2) AND PsA (2). The mean duration of follow up was 8±1.7 months. 10% patients reported adverse events like injection site pain (4.29%), fever (2.86%), redness (1.42%) and weight gain (1.42%). 45% patients had LTBI screen positive and were initiated on chemoprophylaxis with Rifampicin and INH 4weeks prior to Intacept. About 24% of patients dropped due to various reasons like affordability issue (5.7%), inadequate response (8.6%), no response (10%) and side effects (5.7%). 51.4% patients observed more than 50% improvement in global disease activity with Intacept while 10% patients did not get any response with the treatment. 77.2% patients perceived the overall therapy with Intacept as excellent, very good, good or OK while 22.8% patients rated Intacept therapy as non-satisfactory.Conclusions: The study leads to the conclusion that Intended biosimilar of etanercept (Intacept) was safe and well tolerated in various rheumatic disorders in a real-world scenario.
Sociodemographic profile of patients and prescribing trend of drugs in organophosphate poisoning at tertiary care teaching hospital in Central India: a descriptive study
Authors: Bhagwate Sudharam T. , Warbhe Rupesh A. , Chavhan Girish K. , Yuwnate Anita H. , Wankhade Anil D.
Published: April 2019

Background: India is an agrarian country, where pesticides are most widely used in farming. Monsoon dependent agricultural practices are common in India. In present study socioeconomic class and prescribing pattern of commonly used drugs in organophosphate poisoning in indoor setting at tertiary care hospital is evaluated. The aim of the study was to evaluate prescribing trend of drugs and socioeconomic class of patients in organophosphate poisoning in monsoon season.Methods: Prospective observational study was conducted at Medical Intensive Care Unit (MICU) and Medicine Wards for 4 months at 540 bedded tertiary care teaching hospital.Results: Total 64 diagnosed cases were enrolled and analyzed in present study (n=64). Maximum number of cases (57.81%) were male followed by female (42.18%). Most of the cases (37.50%) were from the age group of 21-30 years. 49 (76.56%) patients were of primary intentional poisoning followed by 15 (23.43%) patients of accidental poisoning. Most common drugs prescribed were atropine, pralidoxime, cefotaxime and ranitidine. The average amount of atropine and pralidoxime used per patient/day were 37.89±63.63 mg and 10.07±26.87 gm respectively.Conclusions: Present study revealed that young male adults with low socioeconomic class from rural background were prone for intentional organophosphate poisoning in central India.
Critical analysis of drug promotional literature available to the medical practitioners
Authors: Pai Kakode Kalyani V. , Bhandare Padma N.
Published: April 2019

Background: To ascertain whether the pharmaceutical companies are following the WHO criteria for “Ethical medicinal drug promotion 1988” and “OPPI Code of pharmaceutical marketing practices, 2012” and to what extent. Also, to evaluate the therapeutic claims made by them in their drug promotional literature and other aspects.Methods: Drug Promotional Literature (DPL) from different pharmaceutical companies was collected from various Medical practitioners and analysed to see if they achieved objectives. Therapeutic claims made by them were classified as authentic, exaggerated, controversial, false, and misinterpreted.Results: Total 250 DPLs were collected and critically analysed for information content. Out of the 11 WHO criteria for ethical medicinal drug promotion (1988), Majority (30%)  followed only 54.54% of the criteria while only 4% followed 100% of the criteria. The total number of claims in the 250 DPL were 354 of which 52.8% were authentic and 47.2% were misleading. From the misleading claims: 28.7% were exaggerated, 34.7% were controversial, 22.8% were false, 23% were ambiguous.Conclusions: This study enabled us to find out to what extent the pharmaceutical industries follow the standard criteria for DPL and evaluate the claims made by them. DPL is one of the important sources of drug information. Some of the pharmaceutical companies failed to follow the WHO criteria while advertising their products in order to make them look more lucrative having an underlying commercial motive. As they influence prescribing patterns of the clinicians, misleading promotional literature would result in irrational prescribing of drugs. To avoid this, DPL has to be critically evaluated.
Drug utilization patterns of antibiotics in outpatient department of educare dental hospital at Malappuram, Kerala, India
Authors: K. Fayisa , P. Anas P. , A. Sudhakar
Published: April 2019

Background: Drug utilization studies aims to evaluate factors related to the prescribing, dispensing, administering and taking of medication, and its associated events. Antibiotic prescription by dental practitioners has an important impact on the rate of general antibiotic prescription use, and an attempt has been made to establish a surveillance system for the monitoring and control of the use of these drugs.Methods: Retrospective record-based study was conducted at outpatient department at Educare Dental College and Hospital, Chattipparamba, Malappuram, Kerala. About 2802 prescriptions were screened, drugs prescribed were noted, tabulated and analysed.Results: Total no. of prescriptions 2802, total no. of antibiotics prescribed 2916, average no of antibiotics per prescription 1.04. Out of antibiotics prescribed 72% were monotherapy and 28% were fixed dose combination. Among antibiotics beta lactam antibiotics were commonly prescribed followed by nitroimidazoles and macrolides.Conclusions: The study was conducted to analyze the drug utilization pattern in outpatient department at dental hospital. Most of prescription were rational, both monotherapy and polypharmacy were practiced. Safer drug with less adverse effect profile were considered. Among the antibiotic amoxicillin was the commonest.
A comparative study of moxifloxacin versus combination of doxycycline and metronidazole for treatment of uncomplicated pelvic inflammatory disease
Authors: M. Priyadharshini , Nath Sarmila , Kamilya Gourisankar , Roy Raja
Published: April 2019

Background: Pelvic inflammatory disease (PID), a common condition among women of reproductive age caused by various aerobic and anaerobic organisms, may sometimes lead to complications like infertility, ectopic pregnancy and chronic pelvic pain. Moxifloxacin is a broad spectrum bactericidal antibiotic acting against many gram positive, gram negative aerobic organisms and anaerobes. Rapid absorption and high bioavailability allow single daily dosing and improves compliance. The present study was done to compare the clinical and microbiological outcomes in  PID patients treated with conventional doxycycline- metronidazole  and moxifloxacin therapy.Methods: Women with uncomplicated PID, randomized into two groups either received 400 mg single dose of moxifloxacin daily for 14 days (group A) or doxycycline 100 mg + metronidazole 500 mg twice daily for 14 days (group B). Temperature, TLC count, ESR, CRP, microbiological assessment, Visual analogue score for pain, vaginal discharge, dyspareunia and backache were noted. The bacteriological cure was assessed by high vaginal swab for organism identification by gram stain, 10% KOH and blood sample by ELISA.Results: Total 60 women were enrolled and randomized into two groups. There was significant reduction of CRP and improved TLC in the moxifloxacin treated group. Visual analogue scores for pain, vaginal discharge and malaise were significantly reduced in the group treated with moxifloxacin.  Nausea, vomiting, metallic taste, dyspepsia and diarrhoea were complained by a significant number of patients of doxycycline + metronidazole group, in contrast to the patients receiving moxifloxacin.Conclusions: Moxifloxacin 400 mg once daily, is effective and safe for treatment of PID.