bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of risk-oriented approach to assessing the client during financial monitoring on the real estate market
Authors: Vnukova Nataliya , Davidenko Daria
Published: July 2019

The system of financial monitoring establishes specifically designated entities on the real estate market. The assessment of a client’s risk of money laundering when entering into agreements in this market is a complex task and requires the development of new tools for implementing the risk-oriented approach, which is a priority in accordance with international standards in the financial monitoring system. The purpose of the study is to develop a risk-oriented approach to assessing the client and to develop practical recommendations for determining its level of risk in financial monitoring in the real estate market. To achieve a specific goal, a system of general scientific and special research methods, expert rankings and optimization modeling are used. On the basis of Methodical materials on financial monitoring issues for business entities, which provide services in the course of real estate purchase and sale operations, the points of client’s correspondence to high risk, which corresponds to the concept of developing a risk-oriented approach based on the main criteria of client risk assessment: geographic location of the state, client type and business relations. Taking into account the complexity of such assessment and the necessity of operative decision-making, a risk assessment rating (cost) scale has been developed for an integrated automated determination of a client’s risk level and an assessment of high-risk clients in the Decision Making Helper decision-making support system software on specific examples of legislation violations concerning the financial monitoring on the real estate market. The feasibility of implementing a new risk-oriented approach to assessing high-risk clients has been proved by automating the process of determining its level to reduce the time to decide on prevention and counteraction to the legalization of incomes and money laundering.
CUMHURİYET DÖNEMİ TÜRK EDEBİYATININ “YAZI MAKİNESİ” MURAT SERTOĞLU’NUN POPÜLER EDEBİYATTAKİ YERİ
Authors: EROĞLU KOŞAN Zuhal , SINAR UĞURLU Alev
Published: July 2019

Türk edebiyatında popüler romanlar, genellikle edebî değerden yoksun olmaları nedeniyle hor görülmüş, çok okunan romanlar olmalarına rağmen akademik çalışmalarda ihmal edilmiştir. Bugün bu önyargı yavaş yavaş kırılmaya, popüler romanlar da çeşitli açılardan incelenmeye başlanmıştır. Okuma yazma oranının düşük olduğu Tanzimat ve Meşrutiyet yıllarında popüler romanlar, okuma-yazma oranının artmasını sağlamış, tarihî popüler romanlar ayrıca tarihteki değerleri hatırlatarak ve tarihten hareketle aktüel mesajlar vererek millî bilincin uyanmasında önemli rol üstlenmişlerdir. Toplumda görülen millî temayüller, Cumhuriyet rejiminin kurulmasıyla birlikte yeni devletin temel ideolojisi hâline gelmiştir. Popüler tarihî romanlar da bu dönemden sonra milli değerlerin yerleşmesine hizmet eder. Popüler tarihî roman yazarlarından Murat Sertoğlu da romanlarında bu amacı taşır. Bu çalışmada 56 yıl gibi uzun bir süre yazdıklarıyla Türk halkını peşinden sürükleyen Murat Sertoğlu’nun popüler edebiyat içindeki yeri üzerinde durulacaktır.
Electrocautery Versus Scalpel in Women Undergoing Primary Cesarean Section and Neonatal Outcomes
Authors: Isci Bostanci Esra , Guler Ismail , Cevher Akdulum Funda , Onan Mehmet Anil
Published: July 2019

Objective: The aim of this study is to evaluate the postoperative wound infection rate, newborn effect and, the effect of skin to peritoneum incision time between diathermy and scalpel for the operation time during primer cesarean section cases.Study Design: A retrospective study was carried out at Gazi University Hospital. A total of 74 patients met inclusion criteria in this study but 6 patients were excluded in electrocautery group for not to come controls, group I patients, n=37, underwent operation via scalpel incision and group II patients, n=31, underwent operation by diathermy incision. The main outcome measures were the operation time, postoperative wound infection rate, scar character, neonatal Apgar scores, and need of neonatal intensive care unit.Results: There were no significant differences between newborn Apgar scores (1st and 5th minutes), wound infections, and operation times (p=0.35, p=0.69, p=0.32, respectively).Conclusion: Related to findings, it could be suggested that diathermy might be an alternative to the scalpel in Pfannenstiel incisions contrary to the old belief about its high infection rates.
COMPREENDENDO A NECESSIDADE DE UM CURSO DE FORMAÇÃO SUPERIOR EM LÍNGUA MACUXI A DISTÂNCIA QUE PODERIA SER OFERTADO PELO INSIKIRAN - UFRR.
Authors: Ferreira Paulo , Machado Ananda
Published: July 2019

Este estudo tem por interesse compreender a Formação Superior Indígena Multicultural em como este contexto resguarda uma nova demanda atual: a necessidade que o Instituto de Formação Superior Indígena em Roraima – INSIKIRAN, presente na Universidade Federal de Roraima – UFRR, observe a viabilidade de um Curso de Formação Superior em Língua Macuxi a Distância. Visando cumprir esse propósito, baseado em modelo bibliográfico-qualitativo de pesquisa, a abordagem do tema de fundamentou em publicações textos, teses, artigos e dissertações que favorecessem uma melhor compreensão sobre essa realidade. À medida que o tema fora mais bem discutido, se pôde obter uma melhor visão e conhecimento sobre a Formação Superior Indígena Multicultural.

Palavras-chave: Formação Superior. Multiculturalismo. Línguas Indígenas.
A SOCIOLOGIA DE WEBER NO PENSAMENTO DE ELIAS
Authors: Braga de Faria Júnior Walmir José
Published: July 2019

Com este artigo, objetivamos analisar como certas sugestões de um autor considerado como um clássico da teoria sociológica inspiraram a obra e o pensamento do sociólogo alemão Norbert Elias (1897-1990). No caso, nos concentraremos nas ideias e no referencial de Max Weber (1864-1920). Dessa forma, será descrito como a contribuição do clássico foi retomada pelo autor contemporâneo em dimensões como a união e/ou diálogo entre distintas disciplinas, a compatibilização entre explicar e compreender, e a abordagem de processos de longa duração. Assim, o argumento que perpassa este escrito é que a contribuição do clássico é central para a tarefa de se entender o percurso das ideias do autor contemporâneo, havendo uma articulação criativa, embora nem sempre evidente, das sugestões daquele teórico no cerne da sociologia renovadora praticada por Elias. Para azeitar essa discussão, lançaremos algumas reflexões, em sua maior parte inclinadas a argumentar sobre como a sociologia dos clássicos da sociologia, assim como da sua recepção – além de auxiliarem na compreensão mais sofisticada de contextos intelectuais pontuais, ou de processos sociais mais amplos –, podem ser estratégicas para se melhor recuperar o valor heurístico das contribuições dos clássicos, e até mesmo dos sociólogos contemporâneos.

Palavras-chave: Norbert Elias. Max Weber. Clássicos da Sociologia. Sociologia do Conhecimento.
MICHEL FOUCAULT E O PROBLEMA DA RACIONALIDADE
Authors: Freire Alyson Thiago Fernandes
Published: July 2019

O presente artigo objetiva discutir a abordagem foucaultiana das formas de racionalidade enquanto uma importante atualização crítica do problema da racionalização das sociedades modernas. Desse modo, em sua primeira parte, o artigo se concentra nas principais premissas e cautelas metodológicas do uso do conceito de racionalidade no esquema teórico de Michel Foucault. Por último, exploro como o filósofo francês discorre sobre os vínculos históricos entre racionalidade, poder e crítica.

Palavras-chave: Michel Foucault. Racionalidade. Racionalização. Teoria Social
GESTÃO DE POLÍTICAS PÚBLICAS, PARTICIPAÇÃO DEMOCRÁTICA E INTERNET
Authors: Silva Rosângela , Melo Amanda Raphaela , Ferreira Maria Aparecida
Published: July 2019

O livro, Gestão de políticas públicas, participação democrática e internet: inovação nos modelos de gestão no setor público, é fruto de um projeto de pesquisa desenvolvido no âmbito da Escola Nacional de Administração Pública (Enap), cujo objetivo é fomentar e disseminar pesquisas científicas na área de gestão pública. O texto tem 74 páginas divididas em oito tópicos, além das referências bibliográficas, anexos e apêndices. Seu autor é Júlio Cesar Andrade de Abreu, atualmente é professor dos programas de pós-graduação em Administração Pública (PGPPD/PROFIAP) e Administração (PPGA/MPA), ambos da Universidade Federal Fluminense. Doutor em Administração pela Universidade Federal da Bahia (UFBA), com período de estágio na Universidade Complutense de Madri, Espanha.
A PROBLEMÁTICA SOCIOLÓGICA DO CARISMA
Authors: Silva Emanuel Freitas da
Published: July 2019

O presente artigo tem como objetivo, dentro da proposta do dossiê (discutir a presença dos “clássicos” nos “contemporâneos”, apresentar o conceito sociológico weberiano de carisma, e a sociologia a este identificada, partindo das formulações do sociólogo alemão, passando por seus continuadores e alcançando as apropriações teórico-metodológicas na Sociologia e na Antropologia contemporânea. Destacando os principais desdobramentos da formulação sociológica do termo – carisma como uma crença numa excepcionalidade que engendra uma relação social, que se constitui como uma dominação -, complementamos a análise do uso do conceito com achados de uma pesquisa com as denominadas “Novas Comunidades”, no interior do catolicismo carismático, no intuito de demonstrar a pertinência perene do carisma enquanto categoria sociológica para a compreensão de diferentes ordens simbólicas.
Palavras-chave: Carisma. Relação social. Liderança carismática.
EDITORIAL: Ainda há clássicos que são contemporâneos
Authors: Freitas Carlos , Bueno Arthur
Published: July 2019

Na presente edição, as leitoras e leitores vão conhecer o Dossiê “TEORIA SOCIAL: Os clássicos nos Contemporâneos”, organizado pelos professores Carlos Freitas (UFRN) e Arthur Bueno (Universidade de Frankfurt/Alemanha). O dossiê tem como proposta geral a publicação de artigos inéditos que examinam como os clássicos das ciências sociais se mostram atuais em programas de pesquisa de sociólogos contemporâneos. De modo geral, o dossiê temático é composto por artigos assinados por nomes cientistas sociais de diferentes instituições de ensino e pesquisa do Brasil (UFRN, IFRN, UFPE, UFPB, UFRGS, UFPR, UnB), do Canadá (Universidade de Sydney) e da Alemanha (Universidade de Frankfurt).
COMO ESTRUTURAR UM CURRÍCULO INTEGRADO NUM CURSO DE ODONTOLOGIA?
Authors: Noro Luiz
Published: July 2019

Introdução: Apesar do advento das Diretrizes Curriculares Nacionais (DCN) dos cursos de Odontologia desde 2002, o desenho dos currículos de grande parte dos cursos ainda mantém disciplinas isoladas, sem articulação com os elementos essenciais para a formação de generalistas, com distanciamento entre o ciclo básico e o profissionalizante. Objetivo: Desenvolver proposta de currículo integrado, mediado por metodologias ativas de aprendizagem e avaliação processual da aprendizagem. Método: Para construção da proposta foram identificados eixos sobre os quais foi formulado currículo integrado coerente com as DCN. Resultados: O currículo é composto por cinco eixos: Módulos integrados, Estágio supervisionado, Extensão curricular, Flexibilização e Trabalho de Conclusão do Curso. Os Módulos integrados articulam habilidades e competências que envolvem conhecimentos das áreas básica, clínica e saúde coletiva. O Estágio supervisionado ocorre ao longo dos dois últimos períodos do curso, no Sistema Único de Saúde. A Extensão curricular configura-se pelo desenvolvimento de atividades que articulam a inserção da comunidade com o aprendizado dos alunos, buscando benefícios para o entorno do curso. Para a Flexibilização foram definidos: (1) Atividades complementares e (2) Componentes curriculares optativos, permitindo ao aluno definição do percurso formativo singular. O Trabalho de Conclusão do Curso deve ser desenvolvido de forma transversal desde o primeiro semestre do curso, por componentes curriculares específicos relacionados ao aprendizado das metodologias da pesquisa científica ou nos próprios módulos integrados. Conclusões: Para viabilizar o desenvolvimento do currículo é fundamental a adoção de metodologias ativas de aprendizagem em todos os eixos previstos, permitindo que o aluno construa seu aprendizado. Da mesma forma é fundamental processo de avaliação que contribua efetivamente com uma relação professor-aluno mediada pela busca de conhecimento, permitindo que ambos sejam sujeitos no processo. O principal desafio para alcance da proposta refere-se ao processo permanente de desenvolvimento docente na construção de uma “nova” sala de aula.
AVALIAÇÃO HISTÓRICA DAS POLÍTICAS PÚBLICAS DE SAÚDE INFANTIL NO BRASIL: REVISÃO INTEGRATIVA
Authors: Justino Dayane Caroliny Pereira , Lopes Monique da Silva , Santos Camila Dayze Pereira , Andrade Fábia Barbosa de
Published: July 2019

Introdução: Durante a trajetória histórica que envolve a política de saúde infantil no Brasil, houve pontos positivos e negativos no processo de cuidar, implementado por meio das políticas públicas. Nesse sentido, em vários anos e décadas, foram propostas diretrizes novas que vão ao encontro de uma assistência qualificada à saúde da criança. Objetivo: Analisar a trajetória histórica das políticas de saúde infantil no Brasil verificando as tendências do coeficiente de mortalidade infantil. Método: Revisão integrativa consolidada a partir de pesquisa realizada em documentos de domínio público, disponíveis em formato digital na rede de internet. Foram coletados dados sobre a saúde infantil do período de 1930 a 2016. Resultados: Entre 1930 e 2015 observa-se uma redução na taxa de mortalidade infantil e melhoria na economia do país, além da implantação de várias políticas com ações voltadas diretamente com o objetivo desta redução. Porém, em 2016, um ano após a implantação da última política infantil, observou-se um aumento com 10,2% na taxa de mortalidade infantil referente ao ano anterior. Conclusões: Dessa forma, este estudo mostra que nos últimos 80 anos a taxa de mortalidade infantil vem reduzindo concomitantemente com o aumento de implantações de políticas. Todavia, foi possível ver que ainda se faz necessário melhorias e uma atenção mais direcionada a esta parte da população.
REABILITAÇÃO ESTÉTICA ANTERIOR COM RESINA COMPOSTA: RELATO DE CASO
Authors: Araújo Isabela Dantas Torres de , Abrantes Priscila Silva , Borges Boniek Castillo Dutra , Assunção Isauremi Vieira de
Published: July 2019

Introdução: A avaliação do sorriso deve abranger diversos aspectos desde a composição facial até características morfológicas dos elementos dentários e, dessa forma, se qualquer um desses aspectos forem afetados, o sorriso se torna esteticamente inadequado. Objetivo: apresentar um caso clínico cujo plano de tratamento foi composto pela confecção de facetas diretas em resina composta dos elementos antero-superiores a fim de devolver a estética adequada para a paciente. Descrição do caso: Paciente, 16 anos, do sexo feminino, apresentava má oclusão (Classe III de Angle) compensada ortodonticamente, agenesia de incisivos laterais e inversão dental dos elementos 23 e 24. A resolução estética deste caso utilizou a técnica direta com resina composta por meio do protocolo correto no quesito proporção áurea e mimetização. Conclusão: As restaurações diretas em resina composta são uma solução simples, efetiva e prática na intervenção de desarmonias de forma e tamanho dental e, portanto, foi possível reanatomizar os dentes anteriores devolvendo estética, função e satisfação ao paciente.
Synthesis, In silico and Biological Studies of Thiazolyl-2h-chromen-2-one Derivatives as Potent Antitubercular Agents
Authors: Jadhav Bhagwat S. , Yamgar Ramesh S. , Kenny Rajesh S. , Mali Suraj N. , Chaudhari Hemchandra K. , Mandewale Mustapha C.
Published: July 2019

Background:

A series of new six thiazolyl-2-amine-based Schiff base derivatives (4a-4f) were
synthesized by a sequential multistep reaction starting with Salicylaldehyde.

Methods:

All the Schiff base derivatives were screened in-vitro for their antibacterial activity against Mycobacterium
tuberculosis (H37RV strain) ATCC No-27294. The synthesized compounds were characterized
by FTIR, 1H-NMR, 13C-NMR and Mass spectrometry.

Results:

Among the compounds tested, 4c and 4f derivatives exhibited potent antitubercular activity
against M. tuberculosis at MIC 6.25 μg/mL.

Conclusion:

We extended our study to explore the inhibition mechanism by conducting molecular docking
analysis by using Schrodinger’s molecular modeling software. All the newly synthesized compounds were
found to be in-silico AMES test non-toxic and non-carcinogens. The good Qikprop’s Absorption, Distribution,
Metabolism and Excretion (ADMET) would definitely help the researchers in order to make more potent
Anti-TB agents.
Synthesis, Antimicrobial and Antitumor Evaluations of a New Class of Thiazoles Substituted on the Chromene Scaffold
Authors: Elnaggar Dina H. , Abdel Hafez Naglaa A. , Rashdan Huda R.M. , Abdelwahed Nayera A.M. , Awad Hanem M. , Ali Korany A.
Published: July 2019

Background & Objective:

A new series of thiazoles substituted on the chromene scaffold were prepared by facial approaches starting from (E)-1-(2,3-Dihydrochromen-4-ylidene)thiosemicarbazide derivatives (2a,b). The thiosemicarbazides (2a,b) were reacted with a series of α-halo carbonyl compounds to give the corresponding rhodanine analogues and reacted also with C-acetyl-or Cethoxy- N-hydrazonoyl chlorides to afford the corresponding tri- and tetra-substituted hybrid hydrazinyl thiazole substituted chromenes.

Methods:

The newly synthesized compounds were screened for their in vitro antimicrobial and antitumor activities by agar diffusion method and MTT assay, respectively.

Results:

The results of the antimicrobial activity revealed that some of the new compounds exhibited excellent activity against pathogenic microorganism; Candida albicans compared with Ciprofloxacin and nystatin, as the reference drugs.

:

All of the tested compounds exhibited significant cytotoxic activities comparable to that of the reference drug; Doxorubicin® (on HCT116 (colorectal carcinoma human cell line).
Sam68 Promotes the Progression of Human Breast Cancer through inducing Activation of EphA3
Authors: Chen Xinxin , Zhang Lehong , Yuan Min , Kuang Ziqiao , Zou Ying , Tang Tian , Zhang Wangjian , Hu Xiaowu , Xia Ting , Cao Tengfei , Jia Haixia
Published: July 2019

Background:

Src associated with mitosis of 68 kDa (Sam68), is often highly expressed in
human cancers. Overexpression of Sam68 has been shown to be correlated with poor survival prognosis
in some cancer patients. However, little is known whether Sam68 plays a role in promoting
metastasis in breast cancer.

Materials and Methods:

The expression of Sam68 protein in breast cancer tissue was detected by
immunohistochemistry. Trans-well assay, wound-healing, real-time PCR and Western blotting
analysis were used to detect the effect of Sam68 on promoting EMT or metastasis of breast cancer.
Next-generation RNA sequencing was used to analyze genes that may be regulated by Sam68.

Results:

Sam68 plays a positive role in promoting breast cancer metastasis. Sam68 was found to be
overexpressed in breast cancer along with lymph node metastasis. MMP-9 was also found to be
overexpressed in breast cancer tissue and was correlated to the expression of Sam68 (P<0.01).
Xenograft in NOD/SCID mice and in vitro experiments confirmed that the invasion and metastatic
ability of breast cancer cells were regulated by Sam68. And EPHA3 could be up-regulated by
Sam68 in breast cancer.

Conclusion:

High expression of Sam68 participates in breast cancer metastasis by up-regulating the
EPHA3 gene.
Utilization of the Plant Clusia Fluminensis Planch & Triana Against Some Toxic Activities of the Venom of Bothrops jararaca and B. jararacussu Snake Venom Toxic Activities
Authors: da Silva Aldo Rodrigues , Anholeti Maria Carolina , Pietroluongo Marcia , Sanchez Eladio Flores , Valverde Alessandra Leda , de Paiva Selma Ribeiro , Figueiredo Maria Raquel , Kaplan Maria Auxiliadora Coelho , Fuly André Lopes
Published: July 2019

Background:

In Brazil, the Bothrops genus accounts for 87% of registered snakebites, which are characterized by hemorrhage, tissue necrosis, hemostatic disturbances, and death. The treatment recommended by governments is the administration of specific antivenoms. Although antivenom efficiently prevents venom-induced lethality, it has limited efficacy in terms of preventing local tissue damage. Thus, researchers are seeking alternative therapies able to inhibit the main toxic effects of venoms, without compromising safety.

Objective:

The study aimed to test the ability of aqueous extracts of leaves, stems, and fruits of the plant Clusia fluminensis to neutralize some toxic effects induced by the venoms of Bothrops jararaca and Bothrops jararacussu.

Methods:

The plant extracts were incubated with venoms for 30 min. at 25 °C, and then in vitro (coagulant and proteolytic) and in vivo (hemorrhagic, myotoxic, and edematogenic) activities were evaluated. In addition, the extracts were administered to animals (by oral, intravenous or subcutaneous routes) before or after the injection of venom samples, and then hemorrhage and edema assays were performed. In addition, a gel solution of the fruit extract was produced and tested in terms of reducing hemorrhage effects. A chemical prospection was performed to identify the main classes of compounds present in the extracts.

Results:

All the extracts inhibited the activities of the two venoms, regardless of the experimental protocol or route of administration of the extracts. Moreover, the gel of the fruit extract inhibited the venom-induced-hemorrhage. The extracts comprised of tannins, flavonoids, saponins, steroids, and terpenoids.

Conclusion:

Antivenom properties of C. fluminensis extracts deserve further investigation in order to gain detailed knowledge regarding the neutralization profile of these extracts.
The Possible Role of Telomere Length and Chemokines in the Aging Process: A Transdiagnostic Review in Psychiatry
Authors: Valiati Fernanda Endler , Hizo Gabriel Henrique , Pinto Jairo Vinícius , Kauer-Sant`Anna Márcia
Published: July 2019

Background:

Psychiatric disorders are common, reaching a worldwide prevalence of 29.2%. They are associated with a high risk of premature death and with accelerated aging in clinical, molecular and neuroimaging studies. Recently, there is strong evidence suggesting a possible role of telomere length and chemokines in aging processes in psychiatric disorders.

Objective:

We aimed to review the literature on telomere length and chemokines and its association with early aging in mental illnesses on a transdiagnostic approach.

Results:

The review highlights the association between psychiatric disorders and early aging. Several independent studies have reported shorter telomere length and dysregulations on levels of circulating chemokines in schizophrenia, bipolar disorder, major depressive disorder, and anxiety disorders, suggesting a complex interaction between these markers in a transdiagnostic level. However, studies have investigated the inflammatory markers and telomere shortening separately and associated with a particular diagnosis, rather than as a transdiagnostic biological feature.

Conclusion:

There is consistent evidence supporting the relationship between accelerated aging, telomere length, and chemokines in mental disorders, but they have been studied individually. Thus, more research is needed to improve the knowledge of accelerated senescence and its biomarkers in psychiatry, not only individually in each diagnosis, but also based on a transdiagnostic perspective. Moreover, further research should try to elucidate how the intricate association between the chemokines and telomeres together may contribute to the aging process in psychiatric disorders.
New Anti-inflammatory Triterpene Esters and Glycosides from Alstonia scholaris
Authors: Sultana Nighat , Qazi Muhammad Saleem , Kamal Mustafa
Published: July 2019

Background::

Phytochemical studies on the ethanolic extract of aerial parts of
Alstonia scholaris lead to the isolation of two new triterpenoid of the lanostanetype, lanosta
5ene,24-ethyl-3-O-β-D-glucopyranoside (1), lanosta,5ene,24-ethyl-3-O-β-D-glucopyranosideester
(2) and new ursane type triterpenoidmethylester, 12-ursene-2,3,18,19-tetrol,28
acetate (nighascholarene) (3), together with seven known triterpenes, betuline, triterpene of
the lupane type, alstoprenyol (4), 3β-hydroxy-28-β-acetoxy-5-olea triterpene (5),α-amyrin
acetate (6), α-amyrin (7), lupeol acetate (8), 3β-hydroxy-24-nor-urs-4,12,28-triene triterpene
(9) and ursolic acid (l0).

Methodology::

The triterpenoid structures of these colorless compounds were deduced from
the 1H and 13C-NMR data, and in particular from the application of two-dimensional 1H,
13C correlation experiments as well as by comparison with reported literature data.

Results and Conclusion:

This study deals with isolation and structural elucidation of natural
new triterpenoidesters and glycosides with anti-inflammatory activity.
Differential Expression of TOM34, AL1A1, PADI2 and KLRBA in NNK Induced Lung Cancer in Wistar Rats and their Implications
Authors: Asad Mohammad , Wajid Saima , Katare Deepshikha Pande , Mani Ruchi Jakhmola , Jain Swatantra Kumar
Published: July 2019

Background:

Lung cancer is the most common cancer with a high mortality rate. The diagnosis only at advanced stages and lack of effective treatment are the main factors responsible for high mortality. Tobacco smoke is the major responsible factor for inflammation and tumor development in lungs.

Objective:

The present study was carried out to identify differentially expressed proteins and elucidate their role in carcinogenesis.

Methods:

The lung cancer was developed in Wistar rats by using NNK as carcinogen and cancer development was confirmed by histopathological examination. The 2D SDS PAGE was used to analyse total proteins and find out differentially expressed proteins in NNK treated lung tissue vis-a-vis control tissue. The findings of proteomic analysis were further validated by quantification of corresponding transcripts using Real Time PCR. Finally, Cytoscape was used to find out protein-protein interaction.

Results:

The histopathological examinations showed neoplasia at 9th month after NNK treatment. The proteomic analysis revealed several differentially expressed proteins, four of which were selected for further studies. (TOM34, AL1A1, PADI2 and KLRBA) that were up regulated in NNK treated lung tissue. The real time analysis showed over expression of the genes coding for the selected proteins. Thus, the proteomic and transcriptomic data corroborate each other. Further, these proteins showed interaction with the members of NF-κB family and STAT3.

Conclusion:

We conclude that these proteins play a substantial role in the induction of lung cancer through NF-κB and STAT3 pathway. Therefore, these may have the potential to be used as therapeutic targets and for early detection of lung cancer.
Effect of IV Midazolam Premedication on the Recovery of Pediatric Patients after Isoflurane Anesthesia for Cochlear Implant Surgery
Authors: Hosny Mona R. , Saleh Ashraf N. , Abdelaal Wail A. , Rabie Tahany M.
Published: July 2019

Purpose:

Midazolam, given by varying routes, is widely used as a premedication. This study
was performed to investigate the effect of IV midazolam premedication on
the recovery characteristics from isoflurane anesthesia in pediatric patients
undergoing cochlear implant surgery.

Methods:

In this double-blind randomized study, a total of 60 unilateral cochlear implants procedures were performed on 60 children aged 1 – 6 years. They were 29 males (48.3%) and 31 females (51.7%). Patients were randomly allocated in one of two groups (M and S). Each group included 30 participants. Patients in group M received 0.01 mg/kg IV midazolam in 2 ml of 0.9% saline, while patients in group S received equal volume of 0.9% saline, two minutes before induction. Recovery times from discontinuation of isoflurane were recorded. Postoperative pain was assessed using Objective Pain Discomfort Score (OPDS). Emergence Agitation (EA) was recorded based on Aono’s four-point scale.

Results:

There were statistically significant differences between patients pre-medicated with IV midazolam and those of the normal saline group as regards all measured recovery parameters (p<0.001). Patients in group M scored higher than those in Group S on the OPDS. Yet, this difference didn't show statistical significance (p=0.438) Among patients pre-medicated with midazolam, 17 (56.6%) suffered from EA compared to 12 (40%) patients from the other group. This difference did not reach statistical significance (p=0.196).

Conclusion:

Premedication with IV midazolam delayed recovery in pediatric patients undergoing moderately-long procedures when isoflurane was used as the inhalation anesthetic, while its effect on EA remains uncertain.
Program Penyusutan Arsip di Rektorat Universitas Negeri Yogyakarta
Authors: Putri Adhitya Eka
Published: July 2019

Dalam penyelenggaraan kegiatan administrasi, setiap lembaga perguruan tinggi selalu menghasilkan catatan/rekod. Tidak sedikit rekod, yang juga disebut sebagai arsip dinamis, tercipta melalui kegiatan persuratan. Perguruan tinggi membuat dan menerima surat dalam rangka melaksanakan kegiatan universitas. Seiring dengan waktu, arsip dinamis yang tercipta melalui kegiatan persuratan akan terus bertambah sehingga diperlukan ruangan, sarana dan prasarana, serta biaya yang semakin besar. Dalam rangka merespon persoalan tersebut, perlu dilakukan program penyusutan arsip dinamis agar volume arsip dinamis dapat dikendalikan secara terprogram. Penelitian ini dilakukan terhadap kegiatan penyusutan arsip dinamis di Universitas Negeri Yogyakarta pada tahun 2015-2017. Penelitian ini dilakukan dengan metode kaulitatif dengan pendekatan studi kasus. Penelitian ini bertujuan untuk menjabarkan program penyusutan arsip dinamis serta hambatan-hambatan yang dihadapi dalam kegiatan tersebut. Hasil penelitian menunjukkan bahwa kegiatan pemindahan arsip inaktif dapat dilakukan, namun untuk kegiatan pemusnahan dan penyerahan belum dapat terlaksana karena berbagai sebab.
High-Dose Rituximab and Early Remission in PLA2R1-Related Membranous Nephropathy
Authors: Seitz-Polski Barbara , Dahan Karine , Debiec Hanna , Rousseau Alexandra , Andreani Marine , Zaghrini Christelle , Ticchioni Michel , Rosenthal Alessandra , Benzaken Sylvia , Bernard Ghislaine , Lambeau Gérard , Ronco Pierre , Esnault Vincent L.M.
Published: July 2019

Background and objectives

Different rituximab protocols are used to treat membranous nephropathy. We compared two rituximab protocols in patients with membranous nephropathy.

Design, setting, participants, & measurements

Twenty-eight participants from the NICE cohort received two infusions of 1-g rituximab at 2-week intervals, whereas 27 participants from the Prospective Randomized Multicentric Open Label Study to Evaluate Rituximab Treatment for Membranous Nephropathy (GEMRITUX) cohort received two infusions of 375 mg/m2 at 1-week interval. We measured serum rituximab levels and compared remission at month 6 and before any treatment modification and analyzed factors associated with remission and relapses.

Results

Remissions occurred in 18 (64%) versus eight (30%) from the NICE and GEMRITUX cohort (P=0.02) at month 6, respectively, and in 24 (86%) versus 18 (67%) participants (P=0.12) before treatment modification, respectively. Median time to remission was 3 [interquartile range (IQR), 3–9] and 9 [IQR, 6–12] months for NICE and GEMRITUX cohorts respectively (P=0.01). Participants from the NICE cohort had higher circulating level of rituximab and lower CD19 counts (3.3 µg/L [IQR, 0.0–10.8] versus 0.0 [IQR, 0.0–0.0] P<0.001 and 0.0 [IQR, 0.0–2.0] versus 16.5 [IQR, 2.5–31.0] P<0.001) at month 3, lower level of anti-PLA2R1 antibodies at month 6 (0.0 [IQR, 0.0–8.0] versus 8.3 [IQR, 0.0–73.5] P=0.03). In the combined study population, lower epitope spreading at diagnosis and higher rituximab levels at month 3 were associated with remissions at month 6 (13/26 (50%) versus 22/29 (76%) P=0.05 and 2.2 µg/ml [IQR, 0.0–10.9] versus 0.0 µg/ml [IQR, 0.0–0.0] P<0.001 respectively). All non-spreaders entered into remission whatever the protocol. Eight of the 41 participants who reached remission had relapses. Epitope spreading at diagnosis (8/8 (100%) versus 16/33 (48%) P=0.01) and incomplete depletion of anti-PLA2R1 antibodies at month 6 (4/8 (50%) versus 5/33 (9%) P=0.05) were associated with relapses.

Conclusions

Our work suggests that higher dose rituximab protocol is more effective on depletion of B-cells and lack of epitope spreading is associated with remission of membranous nephropathy.
El debriefing, aprendizaje reflexivo en la simulación interprofesional
Authors: Olvera Hugo E. , Barona Nuñez Argimira Vianey , Hernández Gutiérrez Laura S. , López León Erick
Published: July 2019

In the field of interprofessional simulation, an important element for achieving the stated objectives of the simulation scenario is the debriefing. The debriefing is a complex activity that requires certain skills, experience and knowledge from the facilitator or facilitators, who are known as debriefer/s. Their function is to make the participants reflect on the reasons for their actions, their decisions, and how they acted as a team or individually. Its purpose is the acquisition of a significant learning (achieving the learning objectives) that can subsequently be applied in their daily lives. The interprofessional debriefing styles are varied, but basically its structure integrates: a reaction phase, an analysis phase and an application phase; keeping in mind that the basic standards must be maintained when carrying out a debriefing: time, the construction of a safe learning space, identification, and the closure of knowledge gaps. The advantages of performing an interprofessional debriefing goes beyond the objectives of the simulation, since it favors the acquisition of effective communication skills, teamwork, leadership, the notion of error, etc., which can later be applied in the daily clinical practice.
Manejo de recursos en crisis: un camino al trabajo interprofesional
Authors: López León Erick , Barona Nuñez Argimira Vianey
Published: July 2019

The concept of resource management in a crisis was taken from the aviation and adapted to anesthesiology by Dr. David Gaba, in order to reduce medical errors caused by inadequate communication, poor teamwork, lack of material and human resources, etc.
To achieve this goal, along with Drs. Steven Howard and Kevin Fish, they postulated fifteen necessary key points to control crisis situations, which range from getting to know the environment where professionals work, to understanding what is needed to integrate an efficient team. In this paper, we describe the relationship and the importance of resource management in a crisis with interprofesional work, and how to implement the different key points.
La importancia del interprofesionalismo en la seguridad del paciente
Authors: Hernández Gutiérrez Laura Silvia , Barona Nuñez Argimira Vianey , Durán Cárdenas Cassandra , Miranda Ramón Eva , Zamudio Sánchez Vinisa
Published: July 2019

Health professionals, such as doctors, nurses, physiotherapists, social workers, and psychologists, are involved in the care of the patient and its family, but they do not always work together or in an effective ay. This can lead to an inadequate evolution of the patient. Several organizations, such as the WHO, point out that interprofessional education is essential to be able to provide a safer patient care. In first world ountries, education programs that take into consideration interprofessional education are being developed; this will allow professionals to acquire collaborative practices. Interprofessionalism is the process by which professionals reflect and develop prac tices that provide an integrated and coherent response to the needs of the patient, family and society. Undoubtedly, this educational approach is a proposal that requires the integration of efficient work teams focused to provide safe and efficient care to the patients and their families.
Ciencia, tecnología e innovación en el desarrollo de México y América Latina. Dinámicas de innovación y aprendizaje en territorios y sectores productivos, tomo II, María del Carmen del Valle, Ana Mariño, Ismael Núñez (coords.)
Authors: Tolentino Jessica
Published: July 2019

Revista 178
Empresas de software en México y sus vínculos de desarrollo local
Authors: Micheli Thirión Jordy , Oliver Espinoza Rubén
Published: July 2019

El objetivo del presente artículo es caracterizar dinámicas empresariales de la industria de software ubicada en las ciudades de México, Monterrey y Tijuana, a partir de una encuesta realizada a 175 empresas ubicadas en las ciudades arriba mencionadas, durante el año de 2014. La literatura existente sobre esta industria en México privilegia enfoques teóricos sobre innovación y aprendizaje y su aplicación a casos locales. Este trabajo se enmarca en la lógica de los clústeres (Porter, 1998); por tanto, analiza las relaciones con el mercado local en materia de ventas y utilización de recursos humanos, financieros e información, lo que permite evidenciar diferencias regionales de las dinámicas empresariales. Entre ellas, una importante es el peso que tiene la competencia local en la Ciudad de México comparada con las otras dos ciudades.
El (incompleto y breve) regreso de la política industrial: el caso de Argentina 2003-2015
Authors: Lavarello Pablo
Published: July 2019

En un contexto de expansión de la economía mundial, ampliación de brechas tecnológicas y una evolución de precios relativos adversos a la industrialización, Argentina se encuentra entre los países de América Latina en los que la política industrial regresa (en forma parcial y transitoria) a la agenda de política económica. En este trabajo se plantea como hipótesis que pese al regreso de acciones e instrumentos de política industrial que promueven las capacidades tecnológicas y generan un marco de incentivos favorables a la industrialización, las mismas no llegaron a configurar una nueva política industrial dada la baja coordinación y la ausencia de una instancia jerárquica superior de implementación.
La trampa de liquidez, historia y tendencias de investigación: un análisis bibliométrico
Authors: Ugarte Pineda Eva , León Josefina , Parra Gilberto
Published: July 2019

En la trampa de liquidez, la política monetaria expansiva convencional es ineficaz paraalentar la actividad económica. El modelo keynesiano ortodoxo plantea una situación de este tipo como un caso extremo, el cual fue utilizado para justificar la importancia de la política fiscal. El objetivo de este artículo consiste en realizar un análisis cuantitativo (mediante técnicas bibliométricas) y cualitativo para explorar la literatura reciente sobre la trampa de liquidez. La evolución del número de publicaciones en el periodo 1973-2015 devela los eventos económicos (depresión japonesa de los años noventa y crisis financiera mundial de 2007-2008) que renovaron el interés académico en el estudio de este tema. Estos resultados ofrecen una visión esquemática muy acertada sobre la actual agenda de investigación.
Innovación y desarrollo: programa de estímulos a la innovación regional en México
Authors: Moctezuma Patricia , López Sergio , Mungaray Alejandro
Published: July 2019

El presente artículo evalúa el Programa Estímulos a la Innovación (PEI) en México, apartir de su contribución al Sistema Regional de Innovación (SRI) de Baja California,entre los años 2009-2013. Mediante las metodologías del comportamiento adicional,se analizan los efectos al interior de las empresas, y de redes, se analiza el nivel de vinculación e interacciones entre los actores empresariales, científicos y gubernamentales del SRI. Los resultados muestran que al condicionar el financiamiento de los proyectos de innovación a la vinculación de los actores empresariales y científicos, el pei está contribuyendo a fortalecer el sri incentivando el 15% de sus interacciones.
Medios de vida sustentables y contexto de vulnerabilidad de los hogares rurales de México
Authors: Fierros Isael , Ávila Foucat Sophie
Published: July 2019

El artículo identifica cuatro diferentes perfiles de hogares en el sector rural de México,considerando los activos, los niveles de ingresos y los aspectos relacionados con la vulnerabilidad. La clasificación anterior se hizo utilizando un análisis de clúster y el enfoque de los medios de vida sustentables. Los hallazgos encontrados muestran que la diversificación de los medios de vida es una estrategia de subsistencia de los diferentes hogares para enfrentar las dificultades derivadas del limitado acceso a los mercados, la infraestructura física y los daños climatológicos de huracanes y sequías. Asimismo, en el México rural predomina una gran heterogeneidad regional. Esto último invita a reflexionar sobre la urgente necesidad de generar políticas públicas adecuadas para atender las problemáticas de cada perfil de hogares.
Formation of the Chinese School of International Relations: Analytical Approaches and Research Methods
Authors: Grachikov Evgeny Nikolayevich
Published: July 2019

In 1987, the first All-China Conference of international scholars took place in Shanghai, which is associated with the beginning of the process of creating the Chinese School of International Relations. Over these decades, a vast array of scientific literature has accumulated, exploring the interaction China with other countries and world community. The article is devoted to the study of analytical approaches prevailing in the Chinese academic environment in the study of foreign policy and world politics of the PRC, and specifically, in relation to the United States. Deng Xiaoping’s “reform and openness” policy contributed to the revival of the discipline of “international relations” and the intensification of international research in academic institutions and universities in China. A deep and systemic influence on these processes was exerted by several factors: uncritical borrowing of western international political knowledge, full-scale training of Chinese scholars in Western, mainly American, universities, and the translation into Chinese of most theoretical works of Western scientists. Methodological tools which include the analytical approaches used by Chinese scientists are taken from publications on realism, liberalism and constructivism. In realism, the emphasis is done on the balance of power, which is investigated in the framework of foreign policy analysis. The interdependence of China and the United States, primarily economic, the subject of study from the point of view of neoliberalism. The socialization and involvement of China in the world community and the liberal world order led by the United States are constructivist studies of bilateral relations. Yan Xuetong’s “theory of moral realism”, Qin Yaqing’s “theory of relations”, the Shanghai school’s “international symbiosis”, and Tan Shiping’s “social evolution of world politics” did not go beyond these paradigms, but are already used as their own innovative methods in a study of China’s relations with external actors. The article pays special attention to the dual identity of the Chinese state, as a developing country and a global power, which is publicly voiced by its representatives. This duality imposes regulatory restrictions on the use of analytical tools and, of course, affects the results of research.
The BRICS: Paradigm Shift in Dealing with New Challenges
Authors: Martynov Boris Feodorovich
Published: July 2019

The mankind has been actively using a relatively new geopolitical space: the space of information. Obviously, the economic and scientific progress opens new horizons and possibilities, still not clearly understood by people. This brings about many changes, with either good or bad consequences, depending on who uses the information and what aims are pursued. The present system of international relations is characterized by many new features; it’s becoming more “unpredictable” and “chaotic”. Information wars and “fake” news contribute in its turn to the turbulent character of international relations, pushing forward misconceptions and distorted visions of different situations, and thus provoking conflicts. At the same time, the world is badly short of new ideas, which could more adequately answer the global problems. These new ideas could hardly be produced by the “old”, traditional actors. At the same time, the BRICS countries, representing the new “ascending” civilizations of non-Western nature and not being bound in this sense by the rules of “Euro-Atlantic solidarity”, could collectively propose some new approaches to the global issues. BRICS, as a format of states with accelerated economic indices, should lay a wider conceptual platform for its further dynamics. It should provide a more active information policy and elaborate a “new” conceptual basis, founded on rather traditional and “old” principles - common respect for the international law, derived from political and juridical cultures, historic and social practices.
Development of International Relations at the Periphery: The Case of Bangladesh
Authors: Yasmin Lailufar
Published: July 2019

International Relations (IR) is no longer considered as an academic discipline that analyzes the major powers or great powers’ activities only. From its Cold War content of emphasizing on traditional state-centric security, it has traversed a long way to expand its subject matter. Similarly, smaller nations and their imprints on international politics are also emerging as a significant area of inquiry in IR. This article seeks to contribute to this inquiry by discussing Bangladesh’s rising significance and how academic IR addresses this issue. It traces the history of IR in Bangladesh as well as its gradual expansion. It discusses the growth of IR as an academic discipline at the University of Dhaka, Bangladesh, that gradually led to the development of IR studies in other parts of the country. The article documents this growth, which is the first of its kind to trace the rise and development of IR in Bangladesh. It therefore fulfils the lacuna in understanding how and where the growth of IR took place in a non-western country. One might contend what is the relevance of studying IR in Bangladesh. The article argues that despite being physically small , academic IR has generated interest in Bangladesh due to the changing geostrategic significance of the country. The article outlines the rising geopolitical significance of Bangladesh where great powers are interested to come and be a part of Bangladesh’s development. It is in this context, the study of IR becomes more pertinent in Bangladesh.