bluuebunny/crossref_metadata_2025 huggingface dataset:
Evidence that differentiation-inducing factor-1 controls chemotaxis and cell differentiation, at least in part, via mitochondria inD. discoideum
Authors: Kubohara Yuzuru , Kikuchi Haruhisa , Nguyen Van Hai , Kuwayama Hidekazu , Oshima Yoshiteru
Published: June 2017

Differentiation-inducing factor-1 [1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one (DIF-1)] is an important regulator of cell differentiation and chemotaxis in the development of the cellular slime mold Dictyostelium discoideum. However, the entire signaling pathways downstream of DIF-1 remain to be elucidated. To characterize DIF-1 and its potential receptor(s), we synthesized two fluorescent derivatives of DIF-1, boron-dipyrromethene (BODIPY)-conjugated DIF-1 (DIF-1-BODIPY) and nitrobenzoxadiazole (NBD)-conjugated DIF-1 (DIF-1-NBD), and investigated their biological activities and cellular localization. DIF-1-BODIPY (5 µM) and DIF-1 (2 nM) induced stalk cell differentiation in the DIF-deficient strain HM44 in the presence of cyclic adenosine monosphosphate (cAMP), whereas DIF-1-NBD (5 µM) hardly induced stalk cell differentiation under the same conditions. Microscopic analyses revealed that the biologically active derivative, DIF-1-BODIPY, was incorporated by stalk cells at late stages of differentiation and was localized to mitochondria. The mitochondrial uncouplers carbonyl cyanide m-chlorophenylhydrazone (CCCP), at 25–50 nM, and dinitrophenol (DNP), at 2.5–5 µM, induced partial stalk cell differentiation in HM44 in the presence of cAMP. DIF-1-BODIPY (1–2 µM) and DIF-1 (10 nM), as well as CCCP and DNP, suppressed chemotaxis in the wild-type strain Ax2 in shallow cAMP gradients. These results suggest that DIF-1-BODIPY and DIF-1 induce stalk cell differentiation and modulate chemotaxis, at least in part, by disturbing mitochondrial activity.
Patient waiting time in the outpatient clinic at a central surgical hospital of Vietnam: Implications for resource allocation
Authors: Tran Tho Dinh , Nguyen Uy Van , Minh Nong Vuong , Tran Bach Xuan
Published: June 2017

Background: Patient waiting time is considered as a crucial parameter in the assessment of healthcare quality and patients’ satisfaction towards healthcare services. Data concerning this has remained limited in Vietnam. Thus, this study aims to assess patient waiting time in the outpatient clinic in Viet Duc Hospital (Hanoi, Vietnam) in order to enable stakeholders to inform evidence-based interventions to improve the quality of healthcare services.

Methods: A cross-sectional study was conducted from June 2014 to June 2015 in the outpatient clinic at Viet Duc Hospital. Waiting time stratified by years (2014 and 2015), months of the year, weekdays, and hours of the day were extracted from Hospital Management software and carefully calculated. Stata 12.0 was employed to analyze data, including the average time (M± SD), frequencies and percentage (%).

Results: There was a total of 137,881 patients involved in the study. The average waiting time from registration to preliminary diagnosis in 2014 was 50.41 minutes, and in 2015 was 42.05 minutes. A longer waiting time was recorded in the morning and in those having health insurance.

Conclusions: Our results provided evidence that despite the decrease of waiting time from 2014 to 2015, waiting time was much higher among patients having health insurance compared to their counterparts. The findings suggest that human resources promotion and distribution should be emphasized in outpatient clinics and health insurance-related administrative procedures should be simplified.
CASAS: Cancer Survival Analysis Suite, a web based application
Authors: Rupji Manali , Zhang Xinyan , Kowalski Jeanne
Published: June 2017

We present CASAS, a shiny R based tool for interactive survival analysis and visualization of results. The tool provides a web-based one stop shop to perform the following types of survival analysis:  quantile, landmark and competing risks, in addition to standard survival analysis.  The interface makes it easy to perform such survival analyses and obtain results using the interactive Kaplan-Meier and cumulative incidence plots.  Univariate analysis can be performed on one or several user specified variable(s) simultaneously, the results of which are displayed in a single table that includes log rank p-values and hazard ratios along with their significance. For several quantile survival analyses from multiple cancer types, a single summary grid is constructed. The CASAS package has been implemented in R and is available via http://shinygispa.winship.emory.edu/CASAS/. The developmental repository is available at https://github.com/manalirupji/CASAS/.
Information and measuring approaches for quality evaluation of technical means of chronometry
Authors: Яшин  , Yashin Vladimir
Published: June 2017

Monograph examines information and measuring approaches for quality evaluation of technical means of chronometry. The essence of these approaches is to consider the ongoing physical processes to evaluate their quality from the point of view of information theory. The monograph summarizes results of scientific researches concerning application of information and measuring equipment and information technology tools for quality evaluation of technical means of chronometry.
The monograph is addressed to specialists in chronometry, information and measuring equipment and information technology, as well as to all those who are interested in these problems
Management Consulting
Authors: Чуланова  , Chulanova Oksana
Published: June 2017

The manual has been developed and updated in accordance with the Plan for the direction of 38.03.03 "Human Resources Management" and requirements GEF In this area. The publication contains theoretical information Discipline "Management consulting" and "Fundamentals of management" Consultancy ". Methodological materials for self- The student's work is represented by questions of preparation for the exam, Tasks of test control, the theme of research projects from Fractional annotation. Complies with the requirements of the federal state educational institution.
The latest generation of higher education.
For students of educational organizations of higher education (tankLaurels and masters) who study in the direction of "Managing Person-Scrap "," Management "," State and municipal management ", con-Practitioners, HR specialists.
Ecology
Authors: Николайкин  , Nikolaykin N. , Николайкина  , Nikolaykina Natal'ya , Мелехова  , Melehova Ol'ga
Published: June 2017

In the textbook are provided the main data on formation history and developments of ecology as sciences; are considered the main regularities of organisms relationship with the environment at all organization levels; the biosphere in general, limits of its stability; a role and a place of the person in it; and also are stated the reasons and features of ecological crises modern ideas; the undertaken measures on ensuring ecological safety and biosphere and the person sustainable development.
Conforms to requirements of higher education Federal State Educational Standards last generation.
For students of the higher educational institutions which are trained in the technical and natural-science directions.
Personnel management, personnel consulting, modern personnel technologies, outsourcing, outstaffing, leasing, coaching, assessment center, headhunting, outplacement, teambuilding, teambuilding
Authors: Чуланова  , Chulanova Oksana
Published: June 2017

Within the frame of personnel consulting, management tools are offered that help to increase the efficiency of personnel as a company resource and reduce the risks of the personal dependence of modern businesses. "
Ways to increase the productivity of labor creativity
At the enterprise, creating the most favorable conditions for
The solution of personnel-related tasks and the search for the most optimal management style of the enterprise become the main tool of consultants in personnel management.
To ensure a stable position of the company in the market, the latter must have personnel capable of creatively approaching work, strive for innovations, and achieve an optimal final result. It is on the creation and improvement of cooperation between the personnel of the enterprise that is sent
The activity of personnel consultants. Any Russian pre-
It is interested in increasing its competitiveness, which raises the task of selecting the most talented, capable
Think outside the box of workers.
Gradually
A new model for the development and use of human
Resources. Its main features include:
• Orientation to a highly skilled workforce;
• the continuity of the knowledge enrichment process;
• flexibility in the organization of work;
• rejection of traditional personnel policy;
• the formation of a new production culture, oriented to people.
The trunk line of modern HR consulting is to make human resources that are the essence of competitive
Advantages of any organization.
This training manual on the discipline "Staff Consulting" was developed
In accordance with the Federal State Educational
Standard of higher education in the direction of 38.04.03. "Personnel Management" within the disciplines "Personnel Consulting", "
"HR consulting" and in accordance with the Federal State Educational Standard of Higher Education for
Board 38.06.01 "Economics", profile of training 08.00.05 "Economics and management of the national economy", within the framework of the discipline
"Modern problems of personnel management" and training
Final qualification works in these areas.
The actuality of the publication lies in the fact that in the training manual, along with the main approaches of management consulting in general, all the latest technologies
Personnel management. Outsourcing and outstaffing
As a technology of hiring temporary personnel.
Improving policy implementation through collaborative policymaking
Authors: Ansell Christopher , Sørensen Eva , Torfing Jacob
Published: June 2017

We offer a fresh perspective on implementation problems by suggesting that collaborative policy design and adaptive policy implementation will help public policy makers to improve policy execution. Classical implementation theories have focused too narrowly on administrative stumbling blocks and New Public Management has reinforced the split between politics and administration. Attempts to improve policy implementation must begin by looking at policy design, which can be improved through collaboration and deliberation between upstream and downstream actors. We provide a broad overview of how collaborative policymaking and adaptive policy implementation might work in theory and practice.
Properties of Thermally Treated Granular Montmorillonite-Palygorskite Adsorbent (GMPA) and Use to Remove Pb2+ and Cu2+ from Aqueous Solutions
Authors: Lin Shaohua , Zhou Tingting , Yin Shenshen
Published: June 2017

The adsorption properties of clay minerals (e.g. montmorillonite and palygorskite) have been improved through chemical treatment methods. However, the addition of extra chemicals is often not friendly to the environment and powdered clay-mineral adsorbents are inconvenient for some applications. To overcome these drawbacks in the present study, granular montmorillonite-palygorskite adsorbents (GMPA) were successfully prepared using Na-alginate and thermal treatments to improve heavy metal removal from water. The properties of GMPA samples under different calcination temperatures were examined using thermogravimetric (TG) analysis, scanning electron microscopy (SEM), X-ray diffraction (XRD), and specific surface area (BET). The results indicated that loss of mass by GMPA relative to the untreated montmorillonite-palygorskite was due to the loss of water, adsorbed Na-alginate, and mineral decomposition during thermal treatment. Changes in the morphology and crystallinity were significant at calcination temperatures from 500°C to 1000°C. The layered morphology totally disappeared after calcination at 1000°C, while transformation of the montmorillonite and palygorskite to a non-crystalline material was almost complete at 800°C and new crystalline phases appeared. Calcination temperature had a significant influence on the specific surface areas and pore volumes of GMPA. Both the changes in texture and chemical structure affected Pb2+ and Cu2+ removal. The GMPA sample produced at a 600°C calcination temperature was the most promising adsorbent for heavy metal removal from water.
Finite-element-based photoacoustic imaging of absolute temperature in tissue: retraction
Authors: Yao Lei , Huang Hua , Jiang Huabei
Published: June 2017

The referenced article [Opt. Lett.
39, 5355
(2014)OPLEDP0146-959210.1364/OL.39.005355] has been
retracted.
Cardiac Troponins and Their Prognostic Importance in Patients with Suspected Acute Coronary Syndrome and Renal Dysfunction
Authors: Eggers Kai M , Lindahl Bertil , Carrero Juan J , Evans Marie , Szummer Karolina , Jernberg Tomas
Published: June 2017

BACKGROUND

Cardiac troponin (cTn) is important for risk assessment in patients with suspected acute coronary syndrome (ACS). cTn concentrations may, however, be affected by renal dysfunction, and the clinical importance of this interrelation is not well established. We investigated the association between cTnT and cTnI (measured with conventional assays and a more sensitive assay) with the estimated glomerular filtration rate (eGFR) and also assessed the ability of cTn to predict the 1-year all-cause mortality.

METHODS

This retrospective registry-based study used data from 309454 admissions to Swedish coronary care units. cTn associations with eGFR and mortality were assessed using different regression models and by calculating multivariable-adjusted c-statistics.

RESULTS

cTnT concentrations exhibited stronger associations with eGFR than cTnI concentrations (conventional cTnT assay: β = −0.113; more sensitive cTnT assay: β= −0.186; pooled conventional cTnI assays: β = −0.098). Overall, cTnT provided greater prognostic accuracy than cTnI. This was most evident in non-ACS patients with normal or mildly reduced eGFR when using the more sensitive assay. Despite higher mortality rates, no consistent increases in the c-statistics of cTn were seen with severely reduced eGFR irrespective of the presence of ACS or non-ACS.

CONCLUSIONS

cTnT concentrations exhibited stronger associations with reduced eGFR than cTnI concentrations in patients admitted because of suspected ACS. cTnT, particularly when measured using the more sensitive assay, also tended to be a stronger prognosticator. However, the relative significance of the obtained results must be considered in the context of the severity of renal dysfunction and whether ACS is present.
Design und Improvisation
Authors: Frye Annika
Published: June 2017

Designer_innen müssen improvisieren, wenn sie entwerfen. Die Entwicklung des Braun-Rasierapparates ebenso wie die Arbeiten des Designers Sebastian Herkner zeigen, dass Improvisation Modelle und Prototypen hervorbringt und Fertigungsprozesse überlistet. Doch Improvisation ist nicht nur eine Notwendigkeit - sie ist auch konzeptionell von Bedeutung. Als formgebendes Prinzip führt sie seit dem gestalterischen Postmodernismus zu eigenständigen Einzelstücken. In der Nachkriegszeit versuchte man jedoch, Design als einen Planungsprozess darzustellen. Annika Frye belegt: Für diesen rationalistischen Designbegriff, der bis heute die Diskurse über Design prägt, erweist sich ein am Prozess und seinen Improvisationen orientiertes Designkonzept als äußerst folgenreich.
Nahezu unsichtbare Aneignung
Authors: Benze Andrea , Kutz Anuschka
Published: June 2017

Andrea Benze und Anuschka Kutz nehmen Bezug auf den Aneignungsbegriff, wie er in den letzten Jahren in der Sozialpädagogik vor allem mit Blick auf Kinder und Jugendliche weiterentwickelt wurde. In ihrem Beitrag wenden sie diese Diskussion aber auf die Lebensphase des Alterns an. Sie stellen ihre empirische Studie vor, in der sie Seniorinnen und Senioren in ihrem Alltag nach dem biografischen »Bruch« des Ausscheidens aus dem Berufsleben begleitet haben. Deren Strategien zur »Wiederaneignung« von Stadträumen haben Benze und Kutz zeichnerisch und textlich dokumentiert, um so einer wenig beachteten Akteursgruppe in der Aneignung von städtischem Raum im Planungsdiskurs Gehör zu verschaffen.
Discursive Intersexions
Authors: Koch Michaela
Published: June 2017

Life narratives and fiction that represent experiences of hermaphroditism and intersex are at the core of Michaela Koch's study. The analyzed texts from the 19th to the early 21st century are embedded within and contrasted with contemporary debates in medicine, psychology, or activism to reveal the processes of negotiation about the meaning of hermaphroditism and intersex. This cultural studies-informed work challenges both strictly essentialist and constructivist notions. It argues for a differentiated perspective on intersex and hermaphrodite experiences as historically contingent, fully embodied, and nevertheless discursive subject positions.
›unabgegoltene Vergangenheit‹ - umkämpfte Zukunft
Authors: Leucht Robert
Published: June 2017

Robert Leucht widmet sich Blochs vielschichtiger Begriffsarbeit mit Blick auf dessen »Profilierung des Utopischen im Schweizer Exil«, das mit den zwei Emigrationsphasen im Leben Blochs - während des Ersten Weltkrieges sowie unter der nationalsozialistischen Herrschaft - ein politisch und ideologisch besonders bewegtes Feld zwischen »unabgegoltener Vergangenheit« und »umkämpfter Zukunft« absteckt. An den Werken »Geist der Utopie« und »Erbschaft dieser Zeit« vermag Leucht einerseits eine Aufwertung des Utopiebegriffs zu einer realen Möglichkeit aufzuzeigen und andererseits an der von unterschiedlichen politischen Lagern beanspruchten Denkfigur des Unabgegoltenen zu belegen, dass das Utopische hier nicht nur zukunftsgerichtet, sondern auch untrennbar an Vergangenes gebunden ist.
Das Schweigen Gottes
Authors: Miñambres Germán Garrido
Published: June 2017

Germán Garrido Miñambres widmet sich anhand der Metapher der Vorhölle einer »Ästhetik des Exils« in Peter Weiss' Großroman »Die Asthetik des Widerstands«. Dabei geht er von einer Spannung zwischen Exil und Utopie aus, die sich im Rahmen des antifaschistischen Kampfes, den Autor und Protagonist teilen, an der Frage der politischen Beteiligung entzündet. Unter den zahlreichen intertextuellen und metaliterarischen Anspielungen des Romans wird die Dantesche Metapher der Vorhölle ausgewählt, um zu verdeutlichen, inwiefern sich das utopische Imaginäre nicht etwa in der politischen Partizipation verflüssigt, sondern in der »Sprache der Kunst«, für die der Roman unter anderem anhand von Bildbeschreibungen umfangreiches Anschauungsmaterial liefert.
»Die Flüchtlinge trugen eine Vergangenheit in sich, die keinen Ort mehr fand.«
Authors: Zancas Rosa Pérez
Published: June 2017

Rosa Pérez Zancas untersucht »Figurationen der Nicht-Verortung im Werk von Irmgard Keun und Ursula Krechel«. Als Textbasis dienen ihr »Ferdinand, der Mann mit dem freundlichen Herzen« der Exilautorin Keun sowie Krechels in den letzten Jahren erschienene Romane »Shanghai fern von wo« und »Landgericht«, die sich dem historischen Exil widmen. Im Zentrum steht damit die für die Exilforschung so wichtige, aber auch heftig debattierte Figur des Heimkehrers, der sich nach einer ersehnten Rückkehr im Nachkriegsdeutschland mit zerstörten Erwartungen und Hoffnungen auseinandersetzen muss. Pérez Zancas nutzt auf theoretischer Ebene den von Marc Augé geprägten Begriff der Nicht-Orte sowie Michel Foucaults Konzept der Heterotopien und macht es für die fragile Lage der Heimkehrer in eine dystopisch erscheinende Heimat fruchtbar.
Dystopische Visionen
Authors: Bou Enric
Published: June 2017

Enric Bou untersucht das Dystopische im Werk eines der bedeutendsten Lyriker der ersten hispanischen Exilgeneratio, Pedro Salinas. Er zieht unterschiedliche Texte und von Salinas genutzte Textgattungen heran, um die schockhafte Exilerfahrung des Autors in Nordamerika zu erfassen. Besondere Aufmerksamkeit erfährt neben Gedichten und Briefen aus der umfangreichen Korrespondenz des Exilierten sein einziger Roman, »La bomba increible«, der den Abwurf der ersten Atombombe verarbeitet und dabei eine äußerst kritische - dystopische - Perspektive auf die technizistischen Parameter der Aufnahmegesellschaft entwickelt, wobei auch Topoi des Nord-Süd-Gegensatzes eingesetzt werden.
Epiphanische Dystopie und utopische Epiphanie
Authors: Kissel Wolfgang Stephan
Published: June 2017

Wolfgang Stephan Kissel widmet sich einem Autor, dessen utopische Entwürfe nicht auf der Relativierung von Zeit, sondern auf absolut gesetzten Momenten gründen, herausgehoben aus dem zeitlichen Kontinuum: der »utopischen Epiphanie« oder »epiphanischen Utopie« in den Exilromanen Vladimir Nabokovs. »Emphase und Intensität der herausgehobenen Daseinsmomente überspielen alle Erfahrungen von Bruch, Zäsur, Diskontinuität.« In seinem Beitrag, der einen Einblick in ein weiteres großes Exil des 20. Jahrhunderts erlaubt, zeigt Kissel nicht nur auf, wie die komplexen Zeitstrukturen in Nabokovs frühen Texten ästhetisch umgesetzt werden und sich utopisch entfalten, sondern stellt auch deren vielfältige Bezüge zur russischen Moderne, zu Symbolismus und Ästhetizismus dar.
Verspätete Vergangenheit
Authors: Forasté Anna Montané
Published: June 2017

Anna Montané Forasté schließt den Band mit einem Gegenwartsautor, der sein Werk zuvorderst der Suche nach einer adäquaten Erinnerung von Geschichte, von Holocaust und Exil gewidmet hat. Dieses bestimmende Thema im Werk W.G. Sebalds, dem sich die Texte häufig im Modus einer diffusen Trauer nähern, lässt wenig Raum für Utopisches. Es sind daher eher »Randutopien«, die Montané ausmacht, und die auf eine verlustig gegangene Vergangenheit abzielen. Im Mittelpunkt ihres Beitrags steht denn auch eine »verspätete Vergangenheit« in Sebalds Roman »Austerlitz«. Ihre Ausführungen nehmen Walter Benjamins Gedanken auf, die klärendes Licht auf das Paradox einer noch ungeschehenen Vergangenheit in Austerlitz werfen. In der Erinnerung, die nicht zuletzt die Unabschließbarkeit der vergangenen Zeit belegt, erkennt Montané einen verhaltenen utopischen Gestus, der möglicherweise auch der historischen Distanz zu eigen ist, die uns von der Vergangenheit trennt und zugleich einen offenen Blick auf sie erlaubt.
»Perry Rhodan« lesen
Authors: Nast Mirjam
Published: June 2017

Welche Bedeutung hat Serialität für den Lektüreprozess? Anhand der Heftromanserie »Perry Rhodan« untersucht Mirjam Nast ein breites Spektrum von Lektürepraktiken: Basierend auf einem Spiralmodell des Serienlesens berücksichtigt sie auch zurückliegende Serienerfahrungen und arbeitet Lektüremodi heraus, die sich über längere Zeit des Serienlesens entwickelt haben. Im Anschluss an die Akteur-Netzwerk-Theorie versteht die Studie Lesen als ein Zusammenspiel unterschiedlicher Akteure, zu denen neben den Leser_innen auch die Serie mit ihren materiellen und ästhetischen Aspekten gehört.
Solidarität bilden
Authors: Pfützner Robert
Published: June 2017

Während sozialistische Pädagogik lange Zeit vergessen schien, wird in jüngster Zeit vor dem Hintergrund der globalen Krise des Kapitalismus ihre Wiederentdeckung diskutiert. Robert Pfützner leistet mit seiner systematischen Rekonstruktion sozialistischen Nachdenkens über Solidarität und Pädagogik zwischen 1789 und 1918 einen Beitrag dazu und entwickelt die Idee einer aktuellen Pädagogik der Solidarität. Er stellt frühsozialistische, marxistische und sozialdemokratische Konzepte vor und legt dabei die erziehungs- und bildungstheoretischen Potenziale sozialistischer Traditionen jenseits der offiziellen Sowjet- und DDR-Rhetorik offen.
Erfahrungsraum Spezialschule
Authors: Lessing Wolfgang
Published: June 2017

Die Frage nach der Förderung von hochqualifiziertem musikalischen Nachwuchs hat die Ausbildungsinstitutionen in den vergangenen Jahren vor große Herausforderungen gestellt. In diesem Zusammenhang wurden immer wieder die vier ehemaligen Spezialschulen der DDR als Vorbild beschworen. Eine wissenschaftliche Auseinandersetzung mit diesem Modell blieb bislang allerdings aus. Anhand qualitativer Interviews zeichnet Wolfgang Lessing den Erfahrungsraum dieser Schulen nach und liefert damit wertvolle Impulse für all jene, die sich mit musikalischer Begabungsforschung und der Frage nach einer bestmöglichen Förderung des musikalischen Nachwuchses auseinandersetzen.
Koloniale Grüße aus Samoa
Authors: Förderer Gabriele
Published: June 2017

Der Inselstaat Samoa, die »Perle der Südsee«, ruft Assoziationen vom »Mythos Südsee« und paradiesischen Inselwelten hervor. Dabei war die Inselgruppe im Südpazifik an der Wende vom 19. zum 20. Jahrhundert ein hochpolitischer Schauplatz: Gleich drei Kolonialmächte erhoben Ansprüche auf die Inseln. Wie gestaltete sich in diesem Spannungsfeld der Diskurs in zeitgenössischen Reiseberichten? Welche Argumentationslinien zeichnen sich ab? Und welche Funktionen hatten diese? In ihrer historischen Diskursanalyse zieht Gabriele Förderer erstmals Reiseberichte deutscher, englischer und US-amerikanischer Akteur_innen heran und skizziert so ein differenziertes und hoch ambivalentes Bild der Darstellungen Samoas.
Analisis Efektivitas Jalur Evakuasi Bencana Banjir
Authors: Samto Atmodjo Pranoto , Sangkawati Sri , Bayu Setiaji Arief
Published: June 2017

The flood disaster is one of the natural phenomena that are difficult to avoid. The risk of flood losses that occur in urban areas is generally greater than that occur in the countryside, which it is more due to the differences in the level of public welfare facilities and population density factors The increase in population and the high cost of residential land in urban areas, the greater the pressure of land use for settlement penetrated even in areas that have the potential to floodwaters. To avoid big losses due to flooding and loss of life, it is necessary to disaster management which includes the establishment of alternative evacuation routes, the storage location of refugee. This study will analyze and choose the path of evacuation of the population that are effective and safe as a result of flood-based Geographic Information System (GIS). Stages study began with an analysis of the magnitude of flooding, inundation extents, data collection and analysis of population, density and location of concentrations of residential quarters, global topography and the existing road network system. The study used a case in West Semarang Regency, with a fairly dense population and prone to flooding. Results of this study are expected to be applied to the area of research and can be used as a model for the evacuation of residents due to floods elsewhere.
Efektifitas Pemberlakuan Sistem Satu Arah pada Jalan Indraprasta Kota Semarang dalam Rangka Pemerataan Sebaran Beban Lalu Lintas
Authors: Purwanto Djoko , Eko Yulipriyono EPF
Published: June 2017

The traffic problems in a big city such as Semarang generally caused by the typical situation like overcrowding at peak hours. To overcome this problem, Semarang Government has implemented “One Way System” on the Indraprasta Street section without providing road partner. This study is intended to identify the effectiveness of this policy. The following streets were reviewed: Indraprasta, Imam Bonjol, Mgr. Soegiyopranoto, and Pierre Tendean. Further, the intersections which studied are Indraprasta-Imam Bonjol-Pierre Tendean and Tugu Muda. Traffic survey data were collected in the morning and afternoon peak hours. Manual Kapasitas Jalan Indonesia 1997 was used in the data analysis procedure. This short-term study was conducted by simulating the proposed scenario and compared with the existing situations.In conclusion, “One Way System” on Indraprasta Street section is assessed not effective due to its relatively small degree of saturation, while Mgr. Soegiyopranoto Street has a large degree of saturation. Therefore, the one-way system to Imam Bonjol Street and Mgr. Soegiyopranoto Street also needed to implement and form a “rotary link“. In addition, enacting contraflow for public transport on Soegiyopranoto Street and Imam Bonjol Street is necessary, also the arrangement of signals and geometric in the intersection that linked those three streets.
Hubungan antara Kecepatan dan Kondisi Geometrik Jalan yang Berpotensi Menyebabkan Kecelakaan Lalu Lintas pada Tikungan
Authors: Purwanto Djoko , Kusuma Indriastuti Amelia , Hari Basuki Kami
Published: June 2017

To date, the traffic accident number on hairpin curve is still quite high. This is exacerbated by speeding driving behaviour of some road users.This research aims to identify the factors that cause traffic accidents and drivers’ behaviour at the curve; to review curve geometric design; and to develop a relationship among speed, curve geometric condition and the accident at the curve. This study simply reviewed three hairpin curves that were prone to be blackspots in Batang. The dominant factors that cause accidents were human error and road condition. The driver’s speeding behaviour was indicated by the speed that was lessen when entering and increase when leaving the curve. There were speed variations among vehicles in research location that could increase the number of accident. The results of the geometric review showed that the radius of all curves evaluated did not meet the standard, i.e. less than the minimum radius. Another result of this study was relationships among speed, geometric condition and accident number, as shown by the following formula: Speed = 0.095 Radius + 42.889, No. of accident = - 0.785 Radius + 0.008 Speed - 284.301, and EAN = 0.028 Speed  - 1108.689.
Analisis Perbandingan Pengaruh Penggunaan Flyslab dan Plat Floordeck dalam Mewujudkan Lean Construction
Authors: Sandagie Edwin , Wibowo M. Agung , Purwanggono Bambang
Published: June 2017

Nowadays there are several kinds of products innovations in the construction industry, one of whom is a precast concrete slab. In fact, products of innovation are not necessarily fully able to provide a positive impact, both in terms of cost, quality, time, and waste on building construction projects. Moreover, what is offered by the manufacturer of precast concrete slab has not necessarily correspond with the needs of the customer. The purpose of this study is to analyze the comparison of products in terms of time, cost, quality, and waste between projects using precast concrete slab and the same projects that were simulated using floordeck concrete slab. This research will: (1) simulate the project if not using precast concrete slab product, (2) analyze the comparison of products in terms of time, cost, quality, and waste between the real project and the simulation project, (3) calculate the benefits obtained from the use of precast concrete slab product. The use of flyslab at Pertamina Parking Building Project (which consists of three floors and two floors using flyslab) when compared with the results of the simulation project that uses floordeck concrete slab: (1) in terms of time, it can provide a savings of 12.5% of the total duration of the simulation project, (2) in terms of costs, it can provide costs savings on the total cost structure reaches 23.13%, (3) in terms of quality, flyslab constituent materials are designed to have a higher quality when compared to floordeck concrete slab constituent materials, (4) in terms of waste, on a project that uses flyslab, the amount of waste generated is much less when compared to the results of the simulation project that uses a floordeck concrete slab.
Studi Karakteristik Campuran Aspal Beton Lapis Aus (AC-WC) Menggunakan Aspal Penetrasi 60/70 dengan Penambahan Lateks
Authors: Thanaya I Nyoman Arya , Puranto I Gusti Raka , Nugraha I Nyoman Sapta
Published: June 2017

Asphalt on pavement in long term may undergo hardening, so it needs addition of additive that can make it remain flexible. This experiment tried to produce asphalt concrete wearing course (AC-WC) using asphalt penetration 60/70 with the addition of latex, with aim to know the characteristic of AC-WC mix at the optimum of asphalt content with addition of  latex in variation of 0%, 2%, 4%, 6%, 8%, and 10% of the total binder. Latex was initially mixed with the asphalt, then the aggregates were proportioned based on ideal grading. The samples were produced in hotmix process. The density of latex was found 0.977 with dry rubber content of 61.95%. The optimum of asphalt content that was 5.7%, where all Marshall characteristics were met. It was chosen the mix with 4% latex by total binder where all properties of asphalt binder were still met. It was obtained that the Stability value  was 1439.26 kg (≥ 800 kg), Flow 3.84 mm (2-4 mm), Marshall Quotient 379.66 kg / mm (≥ 250 kg / mm), VIM  4.437% (3-5%), VMA 15.280% (≥ 15%), VFB 70.961 (≥ 65%). The mixture that contains latex had better resistance to deformation under dynamic creep loading at 40 °C.
Operator Kawin Silang pada Algoritma Genetik Riil untuk Variabel Rencana Selalu Positif
Authors: Arfiadi Yoyong
Published: June 2017

Genetic algorithms have been used to solve various optimization problems. One of the advantages of genetic algorithms is that they have the ability to solve complex optimization problems in a simple way. By using genetic algorithms, the near global optimum can be achieved easily. Although in the early development, binary coded genetic algorithms are more popular, recently real coded genetic algorithms are widely used to solve engineering problem’s optimization. The advantage of using real coded genetic algorithms is the ability of the crossover operator to explore a larger domain of interest. As a result the use of crossover in real coded genetic algorithms may have a detrimental effect, as it can explore the domain that is very far from the expected domain. In the civil engineering area, most variables are positive. Therefore, it is needed to develop a crossover operator that can produce positive-only offspring. In this paper an asymmetric crossover is proposed to solve this problem. It is shown in the experiments that this crossover has a good performance in achieving optimum results.
Looping‐out mechanism for resolution of replicative stress at telomeres
Authors: Zhang Tianpeng , Zhang Zepeng , Li Feng , Hu Qian , Liu Haiying , Tang Mengfan , Ma Wenbin , Huang Junjiu , Songyang Zhou , Rong Yikang , Zhang Shichuan , Chen Benjamin PC , Zhao Yong
Published: June 2017

Repetitive DNA is prone to replication fork stalling, which can lead to genome instability. Here, we find that replication fork stalling at telomeres leads to the formation of t‐circle‐tails, a new extrachromosomal structure that consists of circular telomeric DNA with a single‐stranded tail. Structurally, the t‐circle‐tail resembles cyclized leading or lagging replication intermediates that are excised from the genome by topoisomerase II‐mediated cleavage. We also show that the DNA damage repair machinery NHEJ is required for the formation of t‐circle‐tails and for the resolution of stalled replication forks, suggesting that NHEJ, which is normally constitutively suppressed at telomeres, is activated in the context of replication stress. Inhibition of NHEJ or knockout of DNA‐PKcs impairs telomere replication, leading to multiple‐telomere sites (MTS) and telomere shortening. Collectively, our results support a “looping‐out” mechanism, in which the stalled replication fork is cut out and cyclized to form t‐circle‐tails, and broken DNA is religated. The telomere loss induced by replication stress may serve as a new factor that drives replicative senescence and cell aging.
Pituitary stem cell regulation: who is pulling the strings?
Authors: Cox Benoit , Roose Heleen , Vennekens Annelies , Vankelecom Hugo
Published: June 2017

The pituitary gland plays a pivotal role in the endocrine system, steering fundamental processes of growth, metabolism, reproduction and coping with stress. The adult pituitary contains resident stem cells, which are highly quiescent in homeostatic conditions. However, the cells show marked signs of activation during processes of increased cell remodeling in the gland, including maturation at neonatal age, adaptation to physiological demands, regeneration upon injury and growth of local tumors. Although functions of pituitary stem cells are slowly but gradually uncovered, their regulation largely remains virgin territory. Since postnatal stem cells in general reiterate embryonic developmental pathways, attention is first being given to regulatory networks involved in pituitary embryogenesis. Here, we give an overview of the current knowledge on the NOTCH, WNT, epithelial–mesenchymal transition, SHH and Hippo pathways in the pituitary stem/progenitor cell compartment during various (activation) conditions from embryonic over neonatal to adult age. Most information comes from expression analyses of molecular components belonging to these networks, whereas functional extrapolation is still very limited. From this overview, it emerges that the ‘big five’ embryonic pathways are indeed reiterated in the stem cells of the ‘lazy’ homeostatic postnatal pituitary, further magnifieden routeto activation in more energetic, physiological and pathological remodeling conditions. Increasing the knowledge on the molecular players that pull the regulatory strings of the pituitary stem cells will not only provide further fundamental insight in postnatal pituitary homeostasis and activation, but also clues toward the development of regenerative ideas for improving treatment of pituitary deficiency and tumors.
Cis- and Trans-regulatory Effects on Gene Expression in a Natural Population of Drosophila melanogaster
Authors: Osada Naoki , Miyagi Ryutaro , Takahashi Aya
Published: June 2017

Cis- and trans-regulatory mutations are important contributors to transcriptome evolution. Quantifying their relative contributions to intraspecific variation in gene expression is essential for understanding the population genetic processes that underlie evolutionary changes in gene expression. Here, we have examined this issue by quantifying genome-wide, allele-specific expression (ASE) variation using a crossing scheme that produces F1 hybrids between 18 different Drosophila melanogaster strains sampled from the Drosophila Genetic Reference Panel and a reference strain from another population. Head and body samples from F1 adult females were subjected to RNA sequencing and the subsequent ASE quantification. Cis- and trans-regulatory effects on expression variation were estimated from these data. A higher proportion of genes showed significant cis-regulatory variation (∼28%) than those that showed significant trans-regulatory variation (∼9%). The sizes of cis-regulatory effects on expression variation were 1.98 and 1.88 times larger than trans-regulatory effects in heads and bodies, respectively. A generalized linear model analysis revealed that both cis- and trans-regulated expression variation was strongly associated with nonsynonymous nucleotide diversity and tissue specificity. Interestingly, trans-regulated variation showed a negative correlation with local recombination rate. Also, our analysis on proximal transposable element (TE) insertions suggested that they affect transcription levels of ovary-expressed genes more pronouncedly than genes not expressed in the ovary, possibly due to defense mechanisms against TE mobility in the germline. Collectively, our detailed quantification of ASE variations from a natural population has revealed a number of new relationships between genomic factors and the effects of cis- and trans-regulatory factors on expression variation.
EL MODELO DE FRANQUICIA COMO ESTRATEGIA PARA EL POSICIONAMIENTO DE LAS PYMES DEL SECTOR RESTAURANT-BAR EN SINALOA
Authors: Morales-Avila Myrna Cristina
Published: June 2017

La presente investigación se realizó en la ciudad de Culiacán, Sinaloa, durante el periodo comprendido de 2015 a 2016, su objeto de estudio son las pequeñas y medianas empresas (PYMES) del giro restaurant-bar; compara el modelo de negocios que utilizan las empresas del mismo sector con modelos de franquicias,esto es, para resolver la problemática a la que se afronta este tipo de negocios en cuanto a las fallas operativas con las que se manejan y a su poca permanencia en el mercado en el que se desarrollan.
CHINA Y SU IMPACTO EN LA INTEGRACIÓN COMERCIAL DE LA ASOCIACIÓN DE NACIONES DEL SUDESTE ASIÁTICO (ASEAN)
Authors: Díaz-González José Andrés , Vega-Quesada Orlando
Published: June 2017

El presente artículo analiza el proceso de integración comercial de los países miembros de la Asociación de Naciones del Sudeste Asiático (ASEAN). Si bien la integración política de estos países está bastante consolidada, una revisión dedistintos indicadores económicos y comerciales muestra una débil integración comercial. Al observar el efecto de la política comercial de China en Asia, se constata que este ayuda a fortalecer la integración comercial de la ASEAN; sin embargo, no lo hace en suficiente medida para poder considerar que existe una integración completa en este aspecto.
Effect of covert recordings from vehicles on the performance of forensic automatic speaker recognition
Authors: Künzel Hermann J.
Published: June 2017

Speech recordings made in vehicles with hidden recording devices (“bugs”) present a number of peculiarities compared to high-quality direct microphone recordings, and also ordinary mobile phone recordings. Inspired by a recent court case the present investigation was undertaken to quantitatively assess the effect of three types of covert recordings, including data transmission, on a widely-used forensic automatic speaker recognition (FASR) system (Batvox 3.1). Using simultaneous high-quality re-recording of speech samples from 50 speakers played back inside four automobiles and one 5-ton RV as a benchmark, equal-error rates (EERs) between zero and 2 % were found. The latter number was obtained for GSM-transmitted voice data. When the acoustic data were not transmitted but stored inside the covert recording device, or recorded and stored on a smartphone placed inside the vehicles, EERs between zero to 0.45 % were obtained. Generally, EERs are similar to those obtained using the same FASR system in studies with non-covert recordings (direct recordings, landline and mobile telephone). No effect of the type or model of the vehicles on EERs was observed.
SECONDARY METABOLITES FROM MICROMONOSPORA SP. (G044)
Authors: Tuan Cao Duc , Huong Doan Thi Mai , Ngan Truong Bich , Quyen Vu Thi , Minh Le Thi Hong , Brian Murphy , Minh Chau Van , Cuong Pham Van
Published: June 2017

In the course of our screening program, the EtOAc extract of a Micromonospora sp. (strain G044) from sponge Tethya aurantium of the sea of Côtô - Thanh Lân exhibited antimicrobial activity against Enterococcus faecalis, Bacillus cereus and Candida albicans. In this paper, we reported the isolation and structural elucidation of six secondary metabolites Cyclo-(Pro-Trp) (1), Cyclo-(Pro-Met) (2), Cyclo-(Pro-Val) (4), N-acetyltryptamine (3), uridine (5), and 2-phenylacetic acid (6) from the cultures broth of Micromonospora sp. (strain G044). The structures of 1 – 6 were determined by analyses of MS and 2D NMR data. All compounds were evaluated for their antimicrobial activity against a panel of clinically significant microorganisms. Compound 1 inhibited Escherichia coli with a MIC value of 128 µg/ml.
A EDUCAÇÃO PROFISSIONAL E TECNOLÓGICA NA MODALIDADE A DISTÂNCIA: HISTÓRIA, BASES LEGAIS E CURSOS NESSA MODALIDADE DE ENSINO
Authors: Silva Hellen Camila , Costa Maria Luisa Furlan
Published: June 2017

Este artigo, de cunho bibliográfico, é resultado parcial da dissertação de mestrado na linha de pesquisa de História e Historiografia da Educação do Programa de Pós-Graduação em Educação da Universidade Estadual de Maringá (UEM), que teve como objeto de estudo a Educação Profissional e Tecnológica na modalidade a distância. Esta proposta de estudo   objetiva discorrer sobre os aspectos históricos e legais da educação profissional e tecnológica a distância, além de apresentar o desenvolvimento dos cursos dessa modalidade de ensino em algumas instituições, como o Instituto Monitor, o Instituto Universal Brasileiro, o Telecurso e a Rede e-TEC, demonstrando a importância dessas práticas de ensino e aprendizagem. Destacamos que a modalidade de educação a distância tem conquistado, nas últimas décadas, um enfoque de destaque no centro das atenções pedagógicas, uma vez que torna possível o acesso de indivíduos que sem ela não teriam condições de frequentar salas de aula presenciais para buscar formação. Assim, a Educação Profissional e Tecnológica na modalidade a distância configura-se como uma estratégia de expansão do ensino que possibilita a formação dos sujeitos ao longo da vida.
O CAMINHO DOS PROFESSORES NA EDUCAÇÃO PROFISSIONAL: percepções sobre o sentido do trabalho e do trabalho docente
Authors: Santos Maria Gerusa , Morais João Kaio Cavalcante , Brandão Pollyanna Araújo
Published: June 2017

O presente artigo é resultado de uma pesquisa realizada durante a disciplina de Formação Docente para Educação Profissional (EP) do Programa de Pós-Graduação em Educação Profissional do Instituto Federal do Rio Grande do Norte (PPGEP/IFRN). A pesquisa de caráter qualitativo teve por objetivo analisar os conceitos de trabalho e trabalho docente de professores que atuam na EP. Foram realizadas entrevistas com professores da área de formação técnica de duas instituições de ensino profissionalizante do município de Natal/RN. Para sistematizar a coleta de dados, utilizamos o instrumento de Análise de Conteúdos de Bardin (2011). Após a análise dos dados, identificamos que os professores concebiam o trabalho docente de forma distinta de outros tipos de trabalho, todavia, não conseguiram sinalizar quais saberes eram específicos da prática docente. Para a realização da referida pesquisa, entre os autores que fundamentaram o referencial teórico, podemos destacar: Antunes (2013), Ciavatta (2012), Marx (1980), Moura (2013), Ramos (2014) e Saviani (2003).
A EDUCAÇÃO PROFISSIONAL NA REDE FEDERAL DE EDUCAÇÃO TECNOLÓGICA SOB O ENFOQUE DO TRABALHO NA ORGANIZAÇÃO TAYLORISTA/FORDISTA
Authors: Baracho Maria das Graças , Ramos Maria da Conceição , Cabral Neto Antônio
Published: June 2017

O presente artigo tem por objetivo fazer uma reflexão acerca  da formação profissional  a ser empreendida em escola técnica tendo, como categoria base de análise o trabalho na sua organização taylorista fordista. Trata-se de um estudo bibliográfico e conta com o apoio teórico de diversos autores, sobressaindo-se ainda Frigotto(1984), Machado(1982), Fonseca(1961), Singer(1987). Partiu-se da análise do  trabalho no Brasil a partir do século XX, enfatizando os anos de 1940 em diante, início da industrialização no respectivo país; nesse contexto, analisa-se o papel da escola industrial e técnica em face das  exigências do capital. Conclui-se, portanto, que o papel dessa escola, ao assumir as nomenclaturas de escolas industrial e técnica, diante da organização do trabalho nos moldes da grande indústria (base técnica eletromecânica), em que a produção se dá em grande escala, decompondo-se em uma  multiplicidade de tarefas que se encomendam a diferentes trabalhadores, a formação profissional expressa pela arquitetura curricular se apresenta calcada em especialidades de diversos ramos da produção e nesse sentido intensifica-se a desqualificação do trabalhador e amplia-se o processo de especialização.