bluuebunny/crossref_metadata_2025 huggingface dataset:
Management of Groundwater Quality in Sodic Soils using Semi-analytical One-dimensional Solute Transport Model
Authors: Sunil Garg  , S. K. Shakya  , Anil Bhardwaj
Published: March 2024

A semi-analytical one-dimensional solute transport model to manage and predict groundwater quality was tested for its application in Golewala, Punjab. The model being semi-discrete and continuous in time has significant computational advantage over the existing ones, especially for long-term predictions. The model was tested for transport of soluble Ca + Mg, CO3 and HCO3 and EC in soil profile with respect to time under barren soil. The results showed that the model can be used to predict the status of total salt concentration at different depths with time and to manage ground water quality in sodic soils.
Development and Evaluation of a Two-Row Revolving Magazine Type Vegetable Transplanter
Authors: Mahesh Kumar Narang  , I.S Dhaliwal  , Gursahib Singh Manes
Published: March 2024

A 2-row vegetable transplanter with revolving magazine type metering mechanism was developed and field evaluated for Brinjal (Solanum melongena L.) crop. The seedlings of brinjal crop were grown in 98 cell (single cell volume of 22 cm3) plug trays in soil less media. Plant missing varied from 2.22 to 4.44 per cent. Upright plants (plants having 00 to 300 planting angle), depth of planting, plant mortality after 20 days were in the range of 8590 %, 5 to 6 cm and 3.33 to 4 %, respectively. The average field capacity of the machine was 0.122 ha.h-1 for brinjal crop.
Drying Kinetics of Cauliflower in a Hot Air Dryer
Authors: Manoj Kumar Gupta  , V.K. Sehgal
Published: March 2024

Cauliflower florets of 4 cm size were dried at three different drying air temperatures viz., 55, 60, and 65°C, with60 m.min-1 of drying air velocity. The drying data were fitted to different semi-theoretical and empirical modelsviz., Newton, Page, Henderson and Pabis, Logarithmic, two-term, two-term exponential, Verma et al., ModifiedHenderson, Midilli, and Wang and Singh models, based on the moisture ratios. The Midilli model was the bestfit over other models and satisfactorily described the thin-layer drying characteristics of cauliflower. Theeffective diffusivity varied from 12.37 X 10-9 to 3.77 X 10-9 m2.s-1 over the temperature range studied. Thetemperature dependence of the diffusivity coefficient was described by the Arrhenius-type relationship. Theactivation energy for moisture diffusion was found to be 42.41 kJ. Mol-1.
Evaluation of Efficacy of Groundwater Level Monitoring Network by Graphical and Multivariate Statistical Techniques
Authors: Deepesh Machiwal  , Jayesh Vaishnav Nimawat  , Kapil Kumar Samar
Published: March 2024

Knowledge of spatial and temporal patterns of groundwater levels is useful to evaluate efficacy of existing groundwater monitoring network. Present study demonstrates application of graphical and multivariate statistical techniques to evaluate monitoring network of 50 sites in hard-rock aquifers of Ahar River catchment of Udaipur, Rajasthan. The graphical analysis included plotting of time plots and box-whisker plots for monthly groundwater levels for three years (May 2006-July 2009). The result revealed that temporal pattern of the groundwater level was almost similar for majority of the sites. Box-whisker plots revealed that the spatial variations of the groundwater levels were smaller in post-monsoon compared to that in the pre-monsoon season. Furthermore, principal component analysis (PCA) of the groundwater levels revealed that the first two principal components (PC) characterized as ‘hydraulic connectivity factor’ and ‘rainfall factor’ explained more than 75% of the total variance. Based on the PCA, the monitoring sites were classified into five groups according to behavior or
Integrated Use of Water and Nutrients through Drip Irrigation in Nagpur Mandarin
Authors: P. Panigrahi  , A. K. Srivastava
Published: March 2024

A field experiment was conducted during 2006-2008 to optimize the combined use of irrigation and fertilizers through drip irrigation for bearing Nagpur mandarin (Citrus reticulate Blanco) plants at Nagpur, Maharashtra, India. The irrigation at 50% (I1), 75% (I2), and 100% (I3) of daily class-A pan evaporation rate (Ep) along with 25% (F ), 50% (F ) and 75% (F ) of recommended dose of fertilizers (RDF: 600 g N + 100 g P O + 200 g K O) were
Value Addition of Crude Glycerol – A Co-product from Biodiesel Production Process
Authors: R. Mythili  , P. Venkatachalam  , D. Uma  , P. Subramanian
Published: March 2024

The crude glycerol obtained as a co-product from biodiesel production process had soap, alcohol, water and catalyst. It contained 8.9% soap, 4.6% ash, 3.7% free fatty acid and had pH of 11.8. More than 21% methanol was recovered from the neutralized glycerol at 65°C. The glycerol, after alcohol recovery, was distilled at 100°C to remove moisture. The moisture-free glycerol was distilled under vacuum at 0.4 mbar for 140°C. The recovery of distilled glycerol was 40.5% of the crude glycerol, and 19% residue was obtained. The distilled glycerol was further purified by filtration using Whatman No.22 filter paper and activated carbon to remove odour and color, respectively. The purified glycerol had 0.77% soap, 0.03% ash and pH of 3.5.
Anthropometry of Agricultural Workers of Madhya Pradesh
Authors: K. N. Agrawal  , P. S. Tiwari  , L. P. Gite  , S. Pharade  , J. Majumdar  , V. Bhushanababu
Published: March 2024

A study was undertaken to create the repository of anthropometeric data of agricultural workers of central India. Based on the population of male as well as female agricultural workers in twenty districts from nine different agro climatic zones of Madhya Pradesh (central India), data on seventy-nine identified body dimensions were collected for 1701 agricultural workers (944 male and 757 female). The selected workers were within the age group of 18-60 years with average age as 29.8 years for male and 33.7 years for female. Among the selected subjects, 7.4% male and 8.1% female workers were prominently using their left hand rather than right hand. The mean (±SD) weight and stature were 51.2±6.4 kg and 1649±59 mm for male, and 45.0±7.3 kg and 1519±54 mm for female workers, respectively. Vertical measurements had fairly good correlation with stature with coefficient of correlation(r) varying from 0.75-0.9 for both male and female workers. Similarly, vertical grip reach sitting, sitting eye height, and sitting acromion height had linear correlation with sitting height (r=0.75-0.85). The mean stature of male workers of Gujarat was higher than that of Madhya Pradesh, while the stature of all other population groups was lower. However, no such trend was observed among the female population of different states of the country. The 5th percentile values should be used for design where the lower limit is the restrictive factor such as operating forces, control reach and height of displays. The 95th percentile value should be used for design, where the upper limit is the restrictive factor such as design of clearances, seat width, backrest width and strap length for knapsack sprayers.
Development of a Batch Type Yield Monitoring System for Grain Combine Harvester
Authors: Manjeet Singh  , Jaskaran Singh  , Ankit Sharma
Published: March 2024

Assessing soil and crop infield variability is crucial and first step of precision agriculture. In precision agriculture, after assessing the in-field variability, the same is taken care of through site-specific planting, site-specific nutrient and other input applications. Batch type yield monitor was developed having load cell of capacity 700 kg with drum size 125x85x80 cm for grain combines to measure the spatial variation of grains for use as single unit or by putting directly in trailer. Combine mounted batch type yield monitor was also developed by fitting an auxiliary tank of size 145×100×85 cm in the main tank and load cell at the bottom of the auxiliary tank. The yield data is displayed over a display unit installed near the driver seat. Yield variability of three different locations having CV of 5.46%, 27.56% and 35.34% were observed during the evaluation of batch type yield monitor. The systems are useful for small and marginal fields because of its low cost and can be used for any crop, or any combine. Yield monitor information can also be geographically referenced for generation of yield maps, which provide year-to-year comparisons of high- and low-yielding areas of a field throughout a crop rotation sequence for better management.
Physico-Chemical and Sensory Quality of Extruded Foods Developed from Rice and Defatted Soyflour /Chickpea Splits Supplemented with Dried Beetroot
Authors: Mridula D  , Dilip Jain  , K.K. Singh  , R.T. Patil  , M. K. Gupta
Published: March 2024

Extrudates were prepared from rice, defatted soya flour (DSF) or dehulled chickpea splits and dried beetroot using a twin-screw extruder and their physico-chemical properties were determined. Expansion ratio ranged from 3.207 to 2.833 and 3.244 to 3.029, while bulk density ranged from 192 to 260 and 162 to 240 kg.m-3, respectively. In both the cases, L* values decreased but a* values increased with increasing level of dried beetroot in the feed material. Protein, fat, ash content, crude fibre, carbohydrates and calories in both types of extrudates varied from 9.48 to13.05%, 0.57 to1.08%, 0.83 to1.73%, 0.79 to1.47%, 76.53 to 81.45%, and 364.37 to 373.06 kcal/100g, respectively. Supplementation levels of dried beetroot (up to 6% by mass) had significant effect on sensory characteristics of extrudates and indicated commercial scope with tailored healthful properties.
Thermal and Storage Characteristics of Biomass Briquettes with Organic Binders
Authors: G.C. Wakchaure  , Indra Mani
Published: March 2024

The thermal and storage characteristics of briquettes made of three different biomasses using four different concentrations of organic binders as molasses, press mud and distillers dry grain were studied. The concentrations of the organic binders were 5, 10, 15 and 20 per cent. The biomass as mustard stalk, mixed waste of tree leaves and grasses (3:1) and wood waste grounded to 5 mm size were converted to briquettes using piston type briquetting machine having three different dies with inner diameter of 41.5, 42.5 and 43.5 mm at corresponding die pressures of 123.4, 117.7 and 112.3 MPa. The calorific values were higher for briquettes prepared using press mud, followed by those with distiller’s dry grain and molasses, as the former mainly depended upon biomass and amount of binders. Bulk density and calorific values decreased with increase in storage period for all types of briquettes. An overall reduction of 49% in bulk density and about 9% in calorific value was found during storage for a period of 180 days. However, all the briquettes remained stable. The briquettes prepared at highest die pressure of 123.4 MPa showed less variation in moisture content, bulk density, tumbling resistance, shattering resistance, resistance to water penetration, calorific values and ash content over the storage period of 180 days as compared to those prepared at the other two die pressures.
Influence of Storage Period on Physical Properties and Quality of Paddy Stored in GIC Silo and Bag Storage under Humid Konkan Climatic Conditions
Authors: N.J.Thakor  , S.C. Patil  , A.A. Sawant  , S.D. Sawant
Published: March 2024

Experiment was conducted to study the influence of storage period and type of storage on the physical properties (bulk density, thousand grain weight, germination, insect infestation, protein content and ash content) and quality of paddy grain stored in galvanized iron corrugated silo and bag storage under humid Konkan climatic conditions. It was found that duration of storage had a profound effect on some of the properties and quality of stored paddy grain. Bulk density of paddy decreased from 510 to 502 kg.m-3 in silo storage and 510 to 501 kg.m-3 in bag storage, thousand grain weight of paddy decreased from 19.3 g to 18.4 g in silo storage and 19.1 g to 17.6 g in bag storage, germination percentage of paddy decreased from 70.6% to 52.3% in silo storage and 69.5% to 49.3% in bag storage, insect infestation increased from 4.7% to 18.8% in silo storage and 4.4% to 20.2% in bag storage, protein content of paddy grain decreased from 8.78% to 7.89% in silo storage and 8.33% to 7.40% in bag storage, ash content of paddy increased from 7.30% to 8.75% in silo storage and 8.20% to 9.20% in bag storage during storage period of 10 months. The moisture content of paddy increased between the month of May and July in both silo and bag storage, and did not vary significantly during the other periods.
Mathematical Model for Shelf-life of Chickpea Sprouts under Modified Atmospheric Packaging
Authors: Ranjeet Singh  , Ashok Kumar  , Jarnail Singh  , S. D. Kulkarni
Published: March 2024

Simulation study compared predicted in-pack gaseous composition of O2 and CO2 with the actual experimental data and predicted in-pack water vapour and temperature as well as the appropriate shelf life of chickpea sprouts. The actual and simulated results for in-pack gaseous composition O2/CO2 was 14.46; 8.45 % and 14.99; 7.92 % for PP package (100g) and 14.22; 8.85 % and 14.21; 10.57 % for 100g of LDPE package containing chickpea sprout under MAP. Verification of developed model considered the prediction of in-pack gaseous composition and storage period packed under PP and LDPE polymeric films with the experimental value and showed a near proximity. A model with the selected quality attribute (lightness of hypocotyl) thus could provide a fair insight into the shelf life of chickpea sprout under modified atmospheric packaging.
Hydrological Process Modelling using RBNN - A Neural Network Computing Technique
Authors: Ajai Singh  , Mohd. Imtiyaz  , R. K. Isaac  , D. M. Denis
Published: March 2024

Severe erosion in the watersheds under Damodar Valley Corporations (DVC), Hazaribagh, Jharkhand, India has been taking place for a long time. Several soil and water conservation measures are being adopted by the Soil Conservation Department in Damodar Valley. For effective planning of soil conservation programmes, hydrologic models have been used, but with several limitations. In the present study, Nagwa watershed under DVC was selected for simulating monthly surface runoff and sediment yield using radial basis neural network (RBNN) model, which requires lesser data. Different sets of input data were employed and it was observed that only average monthly rainfall was sufficient to estimate surface runoff, while average monthly rainfall and average monthly discharge were needed for estimating sediment yield. The RBNN model was trained for the years 1991-2000 and validated for the period 2001-2007. Results indicate that coefficient of determination, R2, Nash-Sutcliffe simulation efficiency, NSE and root mean square error, RMSE (m3.s-1) values for RBNN model were 0.93, 0.92 and 1.25 during training, and 0.73, 0.73 and 0.77 during validation period, respectively. The model performed quite well for simulation of sediment yield with R2, NSE and RMSE values of 0.92, 0.92 and 1822 during training period; and 0.80, 0.70 and 2288 during validation period, respectively. It could be stated that RBNN model based on simple inputs couldbe a powerful tool for simulation of monthly surface runoff and sediment yield.
Optimization of Bread Baking Parameters in Conventional Oven
Authors: Rajender Gundu  , A. K. Datta  , G. C. Jayashree
Published: March 2024

Optimization of baking parameters in conventional oven was done for cup breads to hasten the bread baking process.The breads were baked at three different baking temperatures of 175 oC, 200 oC and 225 oC at 5 min interval in rangeof 5 min to 30 min at each temperature. The crumb moisture content, crust hardness and colour were determined andthe operating parameters were optimized as: (1) 175 oC and 30 min, (2) 200 oC and 25 min and (3) 225 oC and 20 min
Effect of Storage of Fruit on Quality of Citrus Peel Essential Oil
Authors: Kirti R. Jalgaonkar  , S. K. Jha  , R. K. Pal  , S. Sethi  , Archana P. Raina  , A. K. Dubey
Published: March 2024

Physical and chemical quality of essential oil extracted from peel of four stored citrus species (Jatti khatti, Soh sarkar, grapefruit and pummelo) were determined. Refractive indices of peel oil from Jatti khatti, Soh sarkar, grapefruit and pummelo were 1.467, 1.469, 1.471 and 1.471, respectively. Essential oils obtained from all the species were soluble in 95% alcohol at different levels (3-4 ml). While acid value decreased, ester and saponification values of essential oil increased with increasing physiological loss in mass when extracted from fruits stored for increasing duration at both ambient as well as refrigerated conditions. The essential oil from grapefruit had least acid value, while its ester and saponification values were highest indicating its better quality. Quantitatively, the most representative monoterpene was observed to be limonene with concentration of 95.13, 96.23, 93.57, 96.41% in oils of Jatti khatti, Soh sarkar, grapefruit, and pummelo, respectively.
Comparative Performance of Hay Densification Machines
Authors: Chandra Shekhar Sahay  , Prabha Kant Pathak
Published: March 2024

Densification and baling of hay material is required to reduce its volume for easy transport. Three types of densification machines viz. i) stationary baler; ii) movable baler; and iii) field baler were evaluated for densification of different hay materials. The output from stationary, movable and field baler were 0.045, 0.21 and 0.86 t.h-1, respectively. Densification with stationary baler needed all the hay material to be carried to the densification yard, thus increasing man power requirement and costs while movable baler could be moved to the place of availability of raw material. Field baler could collect and bale the harvested hay material spread on field. Field baler also operated under stationary condition with manual feeding of hay material heaped at one place. The cost of operation with stationary, movable and field baler were Rs.14400, 4700 and 1500 Rs.t-1 of bales formed, respectively.
1. ĐẶC ĐIỂM TỔN THƯƠNG NẤM MÓNG QUA PHÂN TÍCH BẰNG DERMOSCOPE
Authors: Hiền Vũ Thị , Vân Trần Cẩm , Sáu Nguyễn Hữu
Published: March 2024

Mục tiêu: Mô tả các đặc điểm tổn thương nấm móng ở bệnh nhân qua phân tích bằng dermoscope tại Bệnh viện Da liễu Trung ương từ tháng 8/2022 đến tháng 8/2023.

Đối tượng và phương pháp: Nghiên cứu mô tả cắt ngang ở 105 bệnh nhân chẩn đoán lâm sàng nấm móng được tiến hành đồng thời chụp phân tích trên dermosope, soi tươi và nuôi cấy định danh. Từ đó mô tả, phân tích các các đặc điểm của nấm móng trên dermoscope so với lâm sàng và xét nghiệm vi sinh.

Kết quả: Trong 105 bệnh nhân được chẩn đoán nấm móng, các đặc điểm tổn thương trên phân tích bằng dermoscope rất có giá trị trong kết luận hình ảnh nấm móng: tổn thương mảng sắc tố màu kem (97,5%), vảy khô (95,1%) hình đinh ngắn (92,6%), dày sừng dưới móng (65,7%), hình đinh ngắn (81,9%), hình ảnh cực quang (63,8%) có độ nhạy tương đối cao. Đặc điểm đường dọc móng màu trắng chiếm ưu thế ở nhóm có căn nguyên là nấm sợi trong khi thay đổi màu sắc móng và dày sừng dưới móng chiếm ưu thế ở nhóm có căn nguyên là nấm men. Các tổn thương ở móng chân bị nhiễm nấm thường nặng hơn móng tay bị nhiễm nấm: tổn thương bờ xa hình răng cưa, hình ảnh cực quang, đường dọc móng màu trắng, tách móng và dày sừng dưới móng.

Kết luận: Đặc điểm tổn thương nấm móng rất đa dạng và Dermoscope là công cụ hữu ích trong đánh giá tổn thương nấm móng.
6. ĐÁNH GIÁ KẾT QUẢ PHẪU THUẬT (THEO QUY TRÌNH RÚT GỌN) CẦU NỐI ĐỘNG - TĨNH MẠCH DÙNG CHẠY THẬN TẠI BỆNH VIỆN THỐNG NHẤT
Authors: Thanh Lê Đình , Nhân Nguyễn Đỗ
Published: March 2024

Mục tiêu nghiên cứu: (1) Đặc điểm lâm sàng, cận lâm sàng bệnh nhân bệnh thận mạn giai đoạn 4,5, chỉ định lọc thận dùng cầu nối thông động-tĩnh mạch tại khoa Ngoại Tim mạch lồng ngực; (2) Kết quả phẫu thuật tạo thông động-tĩnh mạch những bệnh nhân này.

Đối tượng và phương pháp: Mô tả loạt ca bệnh phẫu thuật theo quy trình rút gọn tạo cầu nối độngtĩnh mạch từ 01/2023 - 11/2023 tại Khoa ngoại tim mạch lồng ngực, Bệnh viện Thống Nhất.

Kết quả: 38 trường hợp (23 nam, 15 nữ). Độ tuổi trung bình 62,1 ± 8,7 tuổi. Thời gian phẫu thuật trung bình 72,1 phút, nằm viện 38,3 giờ, vật liệu cầu nối 100% dùng mạch tự thân. Kết quả phẫu thuật cầu nối đạt lưu lượng 97,3%. Biến chứng: 01 nhiễm trùng, 01 tụ máu, 01 tắc cầu nối, không có tử vong.

Kết luận: Thực hiện cầu nối động-tĩnh mạch theo quy trình rút gọn phẫu thuật tại khoa rút ngắn thời gian chờ. Kết quả phẫu thuật khả quan; phù hợp cho những trường hợp đơn giản; mang lại giá trị rất cao về mặt xã hội và quản lý khi giảm tải áp lực cho bệnh viện và đáp ứng nhu cầu ngày càng cao từ bệnh nhân.
9. MỐI LIÊN QUAN GIỮA MẤT TRŨNG HUYẾT ÁP VỚI MỘT SỐ YÊU TỐ TRÊN NAM GIỚI CAO TUỔI MẮC TĂNG HUYẾT ÁP
Authors: Kiều Nguyễn Đặng Phương , Trí Nguyễn Văn
Published: March 2024

Mục tiêu: Xác định tỉ lệ mất trũng huyết áp trên nam giới cao tuổi mắc tăng huyết áp; mối liên quan giữa các yếu tố gồm: tuổi, chỉ số khối cơ thể, hút thuốc lá, rối loạn lipid máu, đái tháo đường, bệnh thận mạn và thuốc hạ áp với mất trũng huyết áp; mối liên quan giữa mất trũng huyết áp với phì đại thất trái, xơ vữa và dày lớp nội trung mạc động mạch cảnh chung qua siêu âm trên nam giới cao tuổi mắc tăng huyết áp.

Đối tượng và phương pháp nghiên cứu: Nghiên cứu cắt ngang mô tả trên nhóm bệnh nhân nam giới cao tuổi mắc tăng huyết áp đang điều trị nội trú tại Bệnh viện Quân Y 175 từ tháng 7/2020 – 05/2021. Chẩn đoán mất trũng huyết áp dựa vào huyết áp tâm thu theo tiêu chuẩn của ESC 2013.

Kết quả: Qua nghiên cứu 112 nam giới mắc tăng huyết áp, độ tuổi trung bình: 70,2 ± 8,9 năm; 33% mắc đái tháo đường; 51,8% mắc bệnh thận mạn; 15,2% kiểm soát huyết áp theo huyết áp lưu động 24 giờ. Tỉ lệ mất trũng huyết áp là 85,7%. Béo phì, bệnh thận mạn, số loại thuốc huyết áp và thời gian uống thuốc huyết áp có liên quan đến mất trũng huyết áp. Và mất trũng huyết áp có liên quan đến dày lớp nội trung mạc động mạch cảnh chung.

Kết luận: Tỉ lệ mất trũng huyết áp trên nam giới cao tuổi mắc tăng huyết áp điều trị nội trú tại Bệnh viện 175 rất cao. Béo phì, bệnh thận mạn, số loại thuốc huyết áp và thời gian uống thuốc huyết áp có liên quan đến mất trũng huyết áp. Và mất trũng huyết áp có liên quan đến dày lớp nội trung mạc động mạch cảnh chung.
12. MỘT SỐ YẾU TỐ QUYẾT ĐỊNH ĐẾN LỰA CHỌN PHẪU THUẬT PHACO CỦA NGƯỜI BỆNH TẠI BỆNH VIỆN MẮT HÀ NỘI, NĂM 2023
Authors: Giáp Nguyễn Văn , Dũng Trương Việt
Published: March 2024

Nghiên cứu mô tả cắt ngang được thực hiện tại Bệnh viện Mắt Hà Nội từ tháng tháng 03/2023 đến tháng 10/2023 trên 211 người bệnh lựa chọn phẫu thuật Phaco.

Mục tiêu: Mô tả yếu tố quyết định lựa chọn phẫu thuật Phaco tại Bệnh viện Mắt Hà Nội năm 2023.

Phương pháp: Nghiên cứu sử dụng thiết kế nghiên cứu mô tả cắt ngang có phân tích.

Kết quả: Tỉ lệ người bệnh có trải nghiệm chung tốt là 63,5%. Tỉ lệ người bệnh trải nghiệm tốt về khả năng tiếp cận dịch vụ; sự minh bạch thông tin và thủ tục khám bệnh, điều trị; cơ sở vật chất, phương tiện; thái độ ứng xử, năng lực chuyên môn của nhân viên y tế; cung cấp dịch vụ lần lượt là 19,0%; 99,5%; 99,5%; 96,7%; 98,1%.

Kết luận: Kết quả giúp lãnh đạo bệnh viện có những điều chỉnh, hành động chiến lược phù hợp để nâng cao chất lượng phục vụ người bệnh.
13. MỨC ĐỘ CĂNG THẲNG VÀ ỨNG PHÓ CỦA SINH VIÊN ĐIỀU DƯỠNG ĐẠI HỌC NGUYỄN TẤT THÀNH KHI THỰC HÀNH LÂM SÀNG TẠI THÀNH PHỐ HỒ CHÍ MINH
Authors: Thảo Kiều Thị Phương , Tiến Võ Minh , Thịnh Nguyễn Thị Xuân , Khương Tô Đình , Châu Trần Thị Quế , Quang Phạm Duy
Published: March 2024

Mục tiêu: Mô tả mức độ căng thẳng, khả năng ứng phó và phân tích một số yếu tố liên quan đến căng thẳng của sinh viên điều dưỡng trường đại học Nguyễn Tất Thành khi đi thực hành lâm sàng tại bệnh viện.

Phương pháp nghiên cứu: Thiết kế nghiên cứu mô tả cắt ngang 509 sinh viên điều dưỡng đang tham gia thực hành (12/2022-09/2023). Phỏng vấn thông qua bộ câu hỏi dựa theo thang điểm PSS và CBI.

Kết quả: Điểm trung bình căng thẳng của sinh viên là 1,98±0,43. Nguyên nhân gây căng thẳng là từ môi trường thực hành lâm sàng (2,53±0,93) và phương án ứng phó là thay thế (3,06±0,86). Có sự khác biệt giữa điểm trung bình căng thẳng do thiếu kiến thức và kỹ năng chuyên môn và biện pháp ứng phó giải quyết vấn đề của sinh viên năm thứ 3 và thứ 4 (p < 0,05).

Kết luận: Mức độ căng thẳng ở mức trung bình. Thiếu kiến thức và kỹ năng chuyên môn và ứng phó giải quyết vấn đề là điểm khác biệt giữa sinh viên năm 3 và năm 4. Qua đó, sắp xếp thời gian giảng lý thuyết và thực hành hợp lý, hỗ trợ tâm lý và chuyên môn cho sinh viên, hợp tác xây dựng chính sách giữa trường-bệnh viện là hoạt động cần thiết trong giảng dạy lâm sàng trong tương lai.
24. NGHIÊN CỨU TÁC DỤNG HẠ ACID URIC MÁU VÀ ĐỘC TÍNH CỦA CAO KHÔ LÁ LỐT TRÊN ĐỘNG VẬT THỰC NGHIỆM
Authors: Tuyết Dương Ánh , Anh Ngô Nguyễn Quỳnh , Thu Vũ Thị Minh , Huyền Nguyễn Thị Thu , Hằng Phạm Thị , Đông Nguyễn Thị , Dương Nguyễn Thùy
Published: March 2024

Mục tiêu: Nghiên cứu tác dụng hạ acid uric máu và độc tính của cao khô Lá lốt được triển khai với mục tiêu đánh giá tác dụng hạ acid uric máu, đánh giá độc tính cấp và bán trường diễn của Cao khô lá lốt.

Phương pháp nghiên cứu: Đánh giá tác dụng hạ acid uric của cao khô lá lốt bằng mô hình gây tăng acid uric cấp khi tiêm kalioxonat qua màng bụng chuột nhắt trắng; thử độc tính cấp của cao khô lá lốt trên chuột nhắt trắng trong 14 ngày; thử độc tính bán trường diễn trên chuột cống trắng trong 28 ngày.

Kết quả: Cao khô Lá lốt liều 300 mg/ kg có tác dụng tác dụng hạ acid uric máu với tỉ lệ giảm 36,3 % (p=0,015) so với lô chứng bệnh. Đồng thời, mẫu cao khô Lá lốt không thể hiện độc tính cấp ở các liều thử nghiệm (không có chuột chết ở các lô thử nghiệm nên chưa xác định được LD50). Khi thử nghiệm độc tính bán trường diễn, mẫu cao khô Lá lốt không thể hiện độc tính trên các thông số đánh giá tình trạng chung, chức năng gan, chức năng thận và chức năng tạo máu khi dùng liều lặp lại 28 ngày trên chuột cống trắng với các mức liều thử 330 mg/kg/ngày và 990 mg/ kg/ngày.

Kết luận: Cao khô Lá lốt có tác dụng hạ acid uric, không có biểu hiện độc tính trên động vật thực nghiệm.
34. ĐÁNH GIÁ TÍNH AN TOÀN CỦA LIỆU PHÁP KHÍ DUNG DỊCH NỔI MÔI TRƯỜNG NUÔI CẤY TẾ BÀO GỐC TRUNG MÔ NGƯỜI STEMSUP Ở BỆNH NHÂN BỆNH PHỔI TẮC NGHẼN MẠN TÍNH
Authors: Thành Bùi Đức , Công Nguyễn Hải , Thế Nguyễn Minh
Published: March 2024

Mục tiêu: Mô tả đặc điểm lâm sàng, cận lâm sàng và bước đầu đánh giá tính an toàn của liệu pháp khí dung dịch nổi môi trường nuôi cấy tế bào gốc trung mô người Stemsup ở bệnh nhân bệnh phổi tắc nghẽn mạn tính (BPTNMT).

Đối tượng và phương pháp nghiên cứu: Đây là một nghiên cứu can thiệp, nhãn mở, đơn nhóm trên 30 bệnh nhân BPNTMT nhóm E được điều trị tại khoa Lao và bệnh phổi - Bệnh viện quân y 175 từ 8/2021 - 12/2023.

Kết quả: 100% bệnh nhân nam giới, có độ tuổi trung bình là 67,5 ± 6,9 tuổi. Điểm trung bình mMRC là 2,23 ± 0,57. 6MWT là 326,7 ± 88,2 m. Điểm CAT trung bình là 18,1 ± 4,9 điểm. Điểm BODE trung bình là 4,33 ± 1,62, trong đó BODE III chiếm tỷ lệ cao nhất (40%), thấp nhất là BODE IV chiếm 10%. Giá trị trung bình các chỉ tiêu thông khí phổi ở bệnh nhân nghiên cứu đều giảm so với SLT, trong đó FEV1 (%SLT) giảm rõ rệt (45,1 ± 14,9%SLT). Tác dụng phụ không mong muốn chỉ gặp 1 trường hợp khó thở tăng chiếm 3,3%. Có 4/30 chiếm 13,3% bệnh nhân có tăng protein C phản ứng mức độ nhẹ và thoáng qua sau 1 tháng khí dung Stemsup. Không gặp trường hợp nào có biến chứng nặng nề sau khi dùng thuốc.

Kết luận: Liệu pháp khí dung dịch nổi môi trường nuôi cấy tế bào gốc trung mô người Stemsup ở bệnh nhân BPTNTM có kết quả dung nạp tốt mà không có tác dụng phụ nghiêm trọng đáng kể. Đây là một phương pháp nhiều hứa hẹn cho việc điều trị bệnh nhân BPTNMT.
39. KẾT QUẢ ĐIỀU TRỊ Ở THAI PHỤ NHIỄM COVID 19 MỨC ĐỘ NHẸ TẠI BỆNH VIỆN PHỤ SẢN HÀ NỘI
Authors: Hà Nguyễn Thị Thu , Đạt Đỗ Tuấn , Thương Phan Thị Huyền
Published: March 2024

Mục tiêu: Nhận xét kết quả điều trị ở thai phụ nhiễm Covid 19 mức độ nhẹ tại Bệnh viện Phụ sản Hà Nội.

Đối tượng và phương pháp nghiên cứu: Nghiên cứu hồi cứu mô tả cắt ngang trên 1261 thai phụ nhiễm Covid 19, trong đó có 1119 thai phụ nhiễm Covid mức độ nhẹ được điều trị tại Bệnh viện Phụ Sản Hà Nội từ tháng 12/2021 đến tháng 04/2022.

Kết quả:Tuổi thai phụ chủ yếu trong nhóm 19-35 tuổi (85,9%). Tuổi thai khi vào viện chủ yếu ≥ 37 tuần (81,1%). 45,6% thai phụ được tiêm 1 mũi vắc xin trở lên. Phần lớn thai phụ có triệu chứng lâm sàng (69,4%) nhưng D-Dimer ở ngưỡng dưới 3500 ng/L (69,1%) và fibrinogen <6 g/L (66,9%). Hầu hết thai phụ mắc Covid 19 ở mức độ nhẹ không cần hỗ trợ hô hấp (93.8%) Phần lớn thai phụ được sử dụng kháng sinh (96,7%) và 100% thai phụ được sử dụng thuốc chống đông. Phần lớn thai phụ nhiễm Covid mức độ nhẹ kết thúc thai kỳ ngay (78,3%), trong đó có 75% thai phụ kết thúc thai kỳ bằng mổ lấy thai. Tỷ lệ kết thúc thai kỳ của thai phụ nhiễm Covid mức độ nhẹ chủ yếu ở tuổi thai ≥ 37 tuần chiếm (92,3%). Phần lớn thai phụ không có biến chứng sau đẻ (91,5%).

Kết luận: Thai phụ nhiễm Covid mức độ nhẹ có triệu chứng lâm sàng ít, không có biến đổi đáng kể trên cận lâm sàng và hầu hết chỉ cần điều trị không đặc hiệu (giảm ho, kháng sinh). Tuy nhiên, hướng xử trí vẫn ưu tiên mổ lấy thai. Cần có kế hoạch tiêm vắc xin phòng bệnh giúp giảm nhẹ triệu chứng và biến chứng khi nhiễm Covid.
Eosinophilic gastroenteritis and colitis related to cow’s milk allergy: A case report
Authors: Tung Nguyen Van
Published: March 2024

Objective: To provide evidence on clinical, laboratory, histopathological features, diagnostic and treatment of primary eosinophilic gastroenteritis in children. Case presentation: A 7-year-old boy admitted to the 108 Military Central Hospital with symptoms of abdominal pain, nausea and vomiting, recurrent diarrhea related to cow's milk intakes. The child was diagnosed with eosinophilic gastroenteritis, combined with increased serum IgE. The disease was stabilized with corticosteroids, oral proton pump inhibitors (PPIs) combined with the elimination of cow's milk from the daily diet. Conclusion: Primary eosinophilic gastroenteritis in children was definitively diagnosed based on exclusion of other causes of eosinophilia and 3 features: Gastrointestinal symptoms, endoscopy showed gastrointestinal eosinophilic infiltration, peripheral eosinophilia. Corticosteroids are the most effective and useful symptom control drugs in most cases in combination with a diet, eliminating the allergic component.
Expression of circulating miRNA-21 and miR-99b in HBV-related liver cirrhosis and hepatocellular carcinoma
Authors: Phuong Le Ha
Published: March 2024

Objective: Our primary objective was to assess whether these miRNAs could serve as potential biomarkers for distinguishing hepatocellular carcinoma (HCC), even in its early stages, from other liver diseases, particularly liver cirrhosis (LC). Subject and method: We conducted a study involving two patient groups: 50 LC and 50 HCC patients. We employed a screening approach utilizing open data sources (PubMed, Science Research, Google Scholar…), alongside bioinformatics analysis tools to identify miRNAs exhibiting high expression levels in cirrhosis and liver cancer. The miRNAs we selected for evaluation included miRNA-21, miRNA-34a, miRNA-99b, and miRNA-224. Result: The expression levels of miRNA-21 in plasma were found to be significantly higher in the HCC group compared to the cirrhosis group (p<0.001). The combination of miRNA-21 or miRNA-99b and AFP had improved diagnostic performance in distinguishing between these two groups compared to single markers. The area under the ROC curve was significantly high as expected when combining miRNA-99b and AFP with AUC = 0.85 (single miRNA-99b: AUC = 0.715). Similarly for the combination of miRNA-21 and AFP, this simple panel also had a good performance with the AUC = 0.794 (single miRNA-21: AUC = 0.715). Conclusion: miRNA-21 and miRNA-99b hold promise as potential biomarkers for the diagnosis of HCC.
Analisis Pengukuran Kinerja Keuangan dan Tingkat Kemampuan Keuangan Daerah dalam Era Otonomi Daerah
Authors: Aminuddin Novia , Winarningsih Srihadi
Published: March 2024

Karakteristik daerah mampu melaksanakan otonomi dapat dilihat dari kemampuan keuangannya yang diukur melalui analisis kinerja keuangan daerah dan tingkat kemampuan daerah. Tujuan penelitian ini adalah untuk mengetahui bagaimana kinerja keuangan daerah dan kemampuan keuangan daerah dalam melaksanakan otonomi daerah di pemerintah daerah Kabupaten/Kota Se-Provinsi Jawa Barat tahun anggaran 2017-2021 dengan menggunakan data sekunder dari Laporan Realisasi Anggaran (LRA). Metode penelitian yang digunakan ialah kuantitatif deskriptif untuk mengukur kinerja keuangan dengan rasio keuangan diantaranya adalah rasio kemandirian keuangan daerah, rasio ketergantungan keuangan daerah, rasio desentralisasi fiskal, rasio efektivitas PAD, dan rasio efisiensi belanja daerah sedangkan untuk mengukur kemampuan keuangan menggunakan share and growth, peta kemampuan daerah, dan IKK (Indeks kemampuan Keuangan). Hasil penelitian dari kinerja keuangan menunjukkan sebagai berikut: Rasio kemandirian keuangan daerah tergolong rendah yang memiliki pola hubungan konsultatif dengan rata-rata mencapai 35,54%. Rasio ketergantungan keuangan daerah tergolong sangat tinggi dengan rata-rata mencapai 70,56%. Rasio desentralisasi fiskal tergolong sedang dengan rata-rata mencapai 22,77%. Rasio efektivitas PAD tergolong efektif secara rata-rata sebesar 99,64%. Rasio efisiensi belanja daerah tergolong kurang efisien dengan rata-rata mencapai 90,90%. Hasil penelitian dari kemampuan keuangan daerah menunjukkan sebagai berikut: rasio share seluruh secara-secara mencapai 22,94% yang berarti peran PAD dalam membiayai belanja daerah masih sangat minim dan hasil dari rasio growth secara rata-rata mencapai 10,72% yang menunjukkan seluruh pertumbuhan PAD Kabupaten/Kota Se-Provinsi Jawa Barat masih rendah. Berdasarkan hasil analisis share and growth dalam Peta Kemampuan Keuangan, terdapat 21 daerah di Kuadran II, 10 daerah di Kuadran III, dan sisanya sejumlah 14 masuk ke dalam Kuadran IV. Berdasarkan Indeks Kemampuan Keuangan (IKK) kemampuan keuangan tinggi sebanyak 13 daerah, sedangkan 13 daerah dengan kemampuan sedang dan sisanya 1 daerah berada di kemampuan rendah.
Pengaruh Perilaku Konsumtif Terhadap Trend Fashion Studi Kasus Mahasiswi Ciayumajakuning
Authors: Pratama Gama , Millah Faizzatul , Aeni Fariyatul , Rokhmatullah Lina , Atikah Nila , Asyarofah Windi
Published: March 2024

Perilaku konsumtif merupakan sifat yang dimiliki oleh setiap individu yang menggunakan harta atau uangnya digunakan secara berlebihan dan sesuai keinginan bukan sesuai dnegan kebutuhan, terutama dalam hal fashion taka sing jika dikalangan anak muda mahasiswi yang saat ini lebih mementingkan fashion ketimbang dengan mementingkan kebutuhan yang sangat dibutuhkan. Dalam penelitian jurnal ini meneliti perilaku konsumtif terhadap trend fashion  pada mashisiswi coayumajakuning. Masalah dalam penelitian ini berkaitan dengan pengaruh perilaku konsumtif terhadap trend fashion studi kasus mahasiswi ciayumajakuning. Tujuan penelitian  mengetahui seberapa besar pengaruh dari perilaku konsumtif terhadap trend fashion bagi mahasiswi ciayumajakuning. Dalam penelitian ini menggunakan metode kuantitatif dengan menyebar kuisioner kepada para mahisiswi ciayumajakuning dengan memperoleh responden sebanyak 34 responden. Hasil dari penelitian menunjukan bahawa terdapat hubungan yang signifikan antara perilaku konsumtif mempengaruhi trend fashion mahasiswi dibuktikan dari nilai signifikasni sebesar 0.001 (p<0,05) bahwa varibel X berpengaruh signifikan terhadap variabel Y. dan memiliki nilai pengaruh sebesar 31,3% yang dipengaruhi oleh Perilaku konsumtif terhadap trend fashion dan 68,7% dipengaruhi oleh variable lain diluar penelitian.
The Utilization of Biomarkers in Stress-Related Diseases
Authors: Agustina Risna , Lesmana Ronny , Zakiyah Neily , Nuriyatus Zahrah Siti , Diantini Ajeng , Helmi Helmi
Published: March 2024

Various internal and external factors negatively affect the homeostatic balance of the individual at the whole-body level and cause a state of stress. Stress affects the state of comfort and causes changes in energy consumption mechanisms to combat its effects. Individuals may be immunocompromised, susceptible to pathogens. Stress biomarkers play an important role in the prognosis of stress-related diseases and disorders, and therapy. In addition, different components have been identified as potent mediators of cardiovascular, central nervous system, hepatic, and nephrological disorders, which can also be used to evaluate these conditions precisely, but with strict validation and specificity. Considerable scientific progress has been made in the quantization and application of these biomarkers. This review describes current advances in biomarker identification, their prognostic and therapeutic value. Articles review were carried out using the scooping review method by identifying research publications that match the theme through an online search system. The result of this review is that 31 stress-related biomarkers have an important role in the prognosis of stress-related diseases and disorders, and have been identified as potent mediators of cardiovascular, central nervous system, hepatic, and nephrological disorders. From this review, it can be concluded that chronic stress can cause pathological responses in the body due to disruption of body homeostasis in the long term, resulting in changes in the value of physiological biomarkers of the body. The specific biomarkers that are affected then can be used as diagnostic or prognostic biomarkers.
Implementation of Quality by Design approach for Development of Optimized Drug Delivery System of Antidepressant Drug
Authors: Sharma Vijay , Singh Lalit , Jaiswal Arpit , Akhtar Md. Semimul
Published: March 2024

The work presented aimed to implement of “Quality by Design” (QbD) approach to develop optimized fast dissolving tablet (FDT) of Fluoxentine. A face centered Central composite design was employed to develop optimized dosage form. FDTs were prepared by direct compression followed using sublimation technique with additive effect of super disintegrants. Impact of independent variables such as concentration of super-disintegrant and sublimating agent was determined on dependent variables i.e. wetting time, disintegration time and drug release. Data optimization was done by developing validation check batches as well as overlay plot developed by statistical software. Optimized formulation shows 18.08 s wetting time (WT), 19.84 s disintegration time (DT) and the drug release was found to be 85.82 % in 5 m. The accelerated stability studies for optimized FDTs shows no significant changes during one month stability studies. In conclusion, the optimized fast dissolving tablets for Fluoxentine was successfully developed employing by QbD approach with least utilization of man, money and efforts.
A qualitative exploration on the impact of Covid-19 pandemic and the feasibility of conducting telepharmacy in a geriatric clinic
Authors: Akma Hamdan Nor Elyzatul , Gnanasan Shubashini , Alias Rosmaliah
Published: March 2024

Introduction: Telehealth has been widely used during Covid-19 pandemic to maintain continuity of care all over the world. Nevertheless, there is a lack of research investigating the impact of Covid-19 pandemic and the feasibility of conducting telepharmacy in geriatric clinics. Therefore, the aims of this study were (1) to explore the pharmacists’ views on the impact of the Covid-19 pandemic on pharmacist-patient consultation and the feasibility of conducting telepharmacy to maintain the continuity of care in the Geriatric Medication Therapy Adherence Clinic (GMTAC). Materials and methods: In this study, we conducted an exploratory study that focused on pharmacists’ view of GMTAC, Malaysia. We conducted 11 semi-structured interviews with pharmacists who had experienced at least one telepharmacy consultation in GMTAC during Covid-19 pandemic. Pharmacists were selected via a purposive and convenience sampling method. NVivo software was used to store and manage the data. The interviews were transcribed and thematically analyzed to identify key themes and subthemes. Results: Eleven pharmacists from public hospitals participated in the study. Three themes emerged on the impact of the Covid-19 pandemic on pharmacist-patient consultation: (1) management of GMTAC services, (2) inefficient communication, and (3) the pandemic's effect on patient behavior. As for the feasibility of conducting telehealth: (1) utility, (2) readiness, and (3) acceptance are the three main themes that emerged. Conclusion: Pharmacists from public hospitals believed that telepharmacy can be used to preserve the continuity of service in the geriatric clinic. However, challenges and barriers pertaining to the adoption and implementation of telepharmacy must be addressed.
Simultaneous Identification and Quantification of Phenylalanine, Glycine and Lysine amino acids and conjugated heterocyclic amines in Maillard chemical model system using RP-HPLC-DAD
Authors: Youseff Rania , soubh Lina , Alassaf Zaid
Published: March 2024

In this study, we developed a simple reversed-phase high-performance liquid chromatography (RP-HPLC) methodology for simultaneous identification and quantification of three types of mix: (1) phenylalanine and PHIP; (2) glycine and MeIQx; (3) lysine and 4,8 DiMeIQx in Maillard chemical model systems. In addition, we investigated the effects of different conditions on decreasing amino acids and heterocyclic amines (HCA) formation in chemical model systems. The results show that the developed methods used to separate the proposed mixes gave a relative standard deviation (RSD)% of less than 2% of peak area and retention time, thus proving the robustness and high reproducibility of the proposed method. The relationship between concentration and peak areas is linear with high statistical significance (p<0.001). The residual and slope of linear regression give a limit of detection LoD) and (LoQ) of phenylalanine and PHIP were (2.92- 0.029 ppm),(9.73- 0.098 ppm),respectively, which indicate the high sensitivity of the developed method. Moreover, the findings illustrate that a water ratio of 20% leads to a decrease in phenylalanine versus the largest amount of PHIP, and phenylalanine is the most active amino acid with a decreasing percentage up to 99%.
Therapeutic potential of Bhiramiyadhi bhavanai choornam in ameliorating scopolamine-induced impaired learning and memory in rats: neuroprotective effects and mechanistic insights
Authors: S. Bhosale Sampada , Sivakkumar S. , Jamadagni Shrirang , S. Arulmozhi
Published: March 2024

This study intended to explore Bhiramiyadhi bhavanai choornam’s (BBC) effect on scopolamine-induced impaired learning and memory in rats. BBC was prepared and subjected to organoleptic and phytochemical investigations. Scopolamine (2mg/kg, i.p.) was injected into all animals except for the vehicle control group. Donepezil 1mg/kg and BBC (215, 430, and 860mg/kg along with a 1:1 ratio of ghee and honey) were administered orally for 14 days to respective groups. The effect of BBC on locomotor activity, olfactory and spatial memory and exploratory behaviour was evaluated. Later, animals were sacrificed, and brain homogenates were tested for levels of malondialdehyde, antioxidant enzymes, acetylcholinesterase, nitric oxide and TNF-α. A statistical evaluation was carried out. Investigating BBC for phytoconstituents, showed that steroids, phenols, tannins, quinones, alkaloids, flavonoids, glycosides, terpenoids and carbohydrates were present. Treatment with BBC reversed scopolamine-induced learning and memory impairment by significantly (p < 0.001) improving behaviour in the Y maze, novel object recognition test and MWM. BBC also decreased oxidative stress induced by scopolamine by increasing reduced levels of antioxidant enzymes and declining MDA, AChE, NO, and TNF- α levels in the rat brain in a rat model of scopolamine-induced learning and memory impairment.
Protective effect of Phaleria macrocarpa Methanolic Fruit Extract against Oxidative Stress in Brine Shrimps
Authors: Mohamad Nor Hazalin Nurul Aqmar , Halim Hasseri , Firzana Rosli Izzah , Aqilah Nazri Nur , Fadzillah Mohsin Hannis , Mohd Zohdi Rozaini , Maretta Ariestanti Donna , Johari James Richard
Published: March 2024

Phaleria macrocarpais one of the commonly usedplants in East Asia as herbal medicines. The extract of Phaleria macrocarpa can exhibit a variety of beneficial pharmacological activities, including anti-diabetic, and antioxidant activities which are primarily contributed by the constituents isolated from different parts of Phaleria macrocarpa. However, there have been only limited attempts to explore the antioxidant properties of this plant in relation to its medicinal use. Therefore, this study was conducted to determine the antioxidant activity and protective effect of P. macrocarpa methanolic fruit (PMFM) extract against oxidative stress in brine shrimp (Artemia salina). The antioxidant activity of PMFM extractwas evaluated using 2, 2-Diphenyl-1-Picrylhydrazyl (DPPH) and Ferric Reducing Antioxidant Power (FRAP) assays.In vitro brine shrimp toxicity assay was performed on nauplii of Artemia salina to determine the toxicity and the protective effects of the PMFM extract. The DPPH and FRAP assays results showed that PMFM extracthas good antioxidant activity.Additionally, treatment with PMFM extract (concentration ranging from 0.05 to 0.2 mg/ml) was able to protect Artemia salinanauplii from the toxic effects of hydrogen peroxide.Thus, the present findings demonstrate that PMFM extractpossesses good antioxidant and protective activity against oxidative stress.
Micro Hydroxyapatite in Bone Regeneration: A Literature Review
Authors: Kurnia Supandi Shafira , Ayu Susilahati Ni Luh Desy , Lubna Lubna , Firdausi Rezkika Yasmin , Krismariono Agung , Maduratna Ernie
Published: March 2024

Background: Periodontal ailment is in a way the most frequent disorder that humanity faces. Severe periodontitis, which affects roughly 743 million people globally around the world, is the sixth-grade greatest prevalence (11.2%) of any illness. Hydroxyapatite (HA) is a major element for bone regeneration. Biocompatibility, bioactivity, low degradation, osteoconduction, osteointegration, and osteoinduction are all big benefits of HA. Osteoinduction is a system wherein osteoprogenitor cells are stimulated to turn into osteoblasts, which then start the development of new bone. Purpose: This study provides a complete overview of the history and evolution of the use of HA for various regeneration applications, as well as evolving trends. Conclusion: By using HA as a scaffold for osteoinduction, osteoprogenitor cells are stimulated to form osteoblasts, which subsequently initiate the construction of new bone.
Peran Citra Destinasi dan E-WOM Terhadap Minat Berkunjung Kembali Melalui Keputusan Berkunjung Pada Wisata Kabupaten Sampang
Authors: Rosi Fahrur , AS Fathor
Published: March 2024

Penelitian ini bertujuan untuk menguji dampak citra destinasi,electronic word of mouth dan keputusan berkunjung terhadap minat berkunjung kembali di desa wisata kabupaten sampang. Penelitian ini dilakukan dengan jumlah sampling101 Responden dengan menggunakan pendekatan kuantitatif asosiatif dengan metode Partial Least Square (SmartPLS). Berdasarkan hasil penelitian 1. Citra destinasi berpengaruh positif dan signifikan terhadap keputusan berkunjung. 2. Citra detinasi berpengaruh positif tidak signifikan terhadap minat berkunjung kembali. 3. Electronic word of mouth berpengaruh positif tidak signifikan terhadap keputusan berkunjung. 4. Electronic word of mouth berpengaruh positif dan signifikan terhadap minat berkunjung kembali. 5. Keputusan berkunjung berpengaruh positif dan signifikan terhadap minat berkunjung kembali.