bluuebunny/crossref_metadata_2025 huggingface dataset:
Efeitos da Contabilidade Mental sobre os Comportamentos de Consumo: Um Estudo com Indivíduos Brasileiros
Authors: Eugênio de Moraes Thais , Pimentel Duarte da Fonseca Ana Carolina , Cintra Yara Consuelo
Published: January 2025

Esta pesquisa teve como objetivo analisar os efeitos da Contabilidade Mental sobre os Comportamentos de Consumo de indivíduos brasileiros. Trata-se de um estudo qualitativo, de caráter descritivo explicativo, realizado por meio de pesquisa bibliográfica e estudo de caso, utilizando o método de Análise de Conteúdo, com categorias de análise pré-definidas. A coleta de dados se deu através de entrevistas semiestruturadas com 27 indivíduos brasileiros, naturais dos 27 estados do Brasil e o corpus da pesquisa foi composto pelas transcrições das 27 entrevistas. Os resultados apontam indícios de ocorrências do processo cognitivo da Contabilidade Mental e seus vieses nas três dimensões das finanças domésticas -. planejamento, renda e cartão de crédito - sendo que, nestas três dimensões, identificaram-se etapas de codificação, categorização e avaliação. Na etapa da codificação, foram encontradas evidências de que as dimensões do planejamento, renda e cartão de crédito são codificadas todas juntas, porque estão todas sob abrangência do planejamento. Ainda na etapa da codificação, os resultados parecem confirmar a ideia de que a fatura do cartão seria um aglomerado de várias perdas menores, sendo editada hedonicamente na forma de integração de perdas. Na etapa de categorização, os entrevistados citaram rótulos para suas receitas e despesas. Na etapa de avaliação, foi possível observar que no Planejamento, os indivíduos planejados tendem à avaliação ex ante e os não planejados tendem à avaliação ex post; na renda, a maioria tende à avaliação ex ante; e no cartão de crédito, todos tendem à avaliação ex post. Finalmente, a categoria de comportamentos de consumo com maior número de indícios de ocorrência da Contabilidade Mental e seus vieses foi a categoria dos comportamentos equilibrados, contrariando a ideia de que os comportamentos excessivos teriam maior relação com a Contabilidade Mental.
CHRONIC NEUTROPENIA REVEALING HYPER IGM SYNDROME: A CASE REPORT
Authors:   Pediatrics Department, Mohammed V Military Instruction Hospital, Rabat., Bahous E. , Abilkassem R. ,   Pediatrics Department, Mohammed V Military Instruction Hospital, Rabat., Radi A. ,   Pediatrics Department, Mohammed V Military Instruction Hospital, Rabat., Kmari M. ,   Pediatrics Department, Mohammed V Military Instruction Hospital, Rabat., Hassani A. ,   Pediatrics Department, Mohammed V Military Instruction Hospital, Rabat., Agadr A. ,   Pediatrics Department, Mohammed V Military Instruction Hospital, Rabat.
Published: January 2025

Hyper IgM syndrome is a well-knownhereditaryimmunodeficiency, first describedin 1961. It iscaused by a defect in B lymphocytes, characterized by a normal or high serumlevel of IgM and a low or zerolevel of IgG, IgA, IgE resultingfrom a deficiency in isotype switching. Itsclinical manifestations are dominated by recurrent infections, especiallyrespiratory and digestive. The interest of this article is to illustrate a particular mode of revelation of hyper IgM syndromes through persistent chronicneutropenia in an infant.
COMPUTATIONAL ANALYSIS OF FLUID-STRUCTURE INTERACTION AND HEAT TRANSFER IN EXTRUSION PROCESSES
Authors:   Dhirubhai Ambani International School., Agarwal Kcavyan , Rana Pinal ,   Dhirubhai Ambani International School.
Published: January 2025

The extrusion process is integral to manufacturing, enabling the production of continuous profiles with precise cross-sections for various industries, including automotive, construction, and aerospace. This study focuses on the computational analysis of material flow and heat transfer during the extrusion of an L-type section under steady-state conditions. Finite element analysis is used to model the extrusion process.The research evaluates the impact of key parameters such as container temperature, ram velocity, and friction coefficients on the billets thermal profile and exit temperature. The study incorporates non-Newtonian flow dynamics, and thermal coupling to provide comprehensive insights into optimizing process efficiency, die design, and material flow uniformity. The results demonstrate the critical role of thermal and frictional parameters in enhancing extrusion quality and preventing material defects.
THE IMPORTANCE AND CONTRIBUTION OF PRECISION AGRICULTURE TECHNOLOGIES IN REDUCING GREENHOUSE GAS EMISSIONS
Authors: K. Fatma , Betul R. Sureyya , Volkan B. Ali
Published: January 2025

Many measures are being taken worldwide to prevent climate change and drought. In developed countries, efforts in the fields of economy, energy and agriculture continue uninterruptedly. Agriculture is greatly impacted by climate change, and unsustainable farming practices are no exception. The agricultural sector produces significant amounts of greenhouse gases, including CO2, N2O, and CH4.Changing carbon stocks in soil and atmospheric air, due to changes in the energy used in agricultural practices and changes in soil management, affects CO2 emissions. There has been a recent movement in the agricultural sector to cut greenhouse gas emissions.While existing studies have demonstrated the effectiveness of sustainable agricultural practices in reducing greenhouse gas emissions, there is limited research specifically examining how Precision Agriculture Technologies (PAT) contribute to these reductions.Accordingly, by accounting for the lands temporal and spatial variability, precision agricultural technologies make it possible to use agricultural inputs efficiently. Agriculture productivity is raised by these cutting-edge technologies, which include precision physical weeding, variable rate sowing, irrigation, pesticide application, and fertilization. Precision Agriculture Technologies (PAT) can contribute to reducing greenhouse gas emissions in agricultural activities, sustaining or increasing productivity, in this context, the variable rate approach to fertilization, irrigation and pesticide application has a significant impact. Remote sensing (satellite imagery, thermal imaging), global positioning system (GPS), lidar (light reflection and detection), drones, geographic information systems (ArcGIS), Google Earth and Global Mapper are also used in precision agriculture practices.By analyzing the impact of these practices in reducing greenhouse gas emissions, the advantages of using (PAT) in future agricultural and climate policy measures can be evaluated. In studies, it has been determined that agricultural activities (fertilization, tillage, irrigation, spraying) carried out using precision agriculture techniques reduce greenhouse gas emissions by 5%-62%. At the same time, it is also stated that it contributes to the economy by saving money by using agricultural input at the required rate. Examining how precision agriculture technologies might reduce greenhouse gas emissions from agricultural sources is the aim of this review.
ACUTE POST HEMORRHAGIC ANEMIA AND SHOCK IN NEONATE DUE TO RUPTURE UMBILICAL CORD DURING DELIVERY
Authors:   Department of Neonatology and Pediatric, Hatta Hospital, Dubai Health, UAE., A.M Osman Hala , S.E Abdul Rhim Fadwa ,   Department of Obstetrics and Gynecology, Hatta Hospital, Dubai Health, UAE., Mukhtar Eyas ,   Department of Neonatology and Pediatric, Hatta Hospital, Dubai Health, UAE., Bizzari Rikaz ,   Department of Neonatology and Pediatric, Hatta Hospital, Dubai Health, UAE., Kalifa Jinan ,   Department of Obstetrics and Gynecology, Hatta Hospital, Dubai Health, UAE.
Published: January 2025

Umbilical cord rupture in utero is a very rare and critical emergency that can cause fetal death within minutes. Umbilical cords rupture can be associated with normal or adverse perinatal outcomes leading to stillbirth, asphyxia, fetal distress, and neurologic damage. When rupture does occur in utero signs of fetal distress appear and fetal mortality rate is approximately 50%. We present the rare case of severe anaemia and shock immediately after delivery related to severe neonatal blood loss due to intrapartum umbilical cord rupture where there was a tight nuchal cord and the placenta was bilobed with a Succenturiate lobe. The umbilical cord ruptures close to the babys side near the abdominal wall.This is an unusual site, as most cases tend to rupture from the weakest site at the insertion of the cord to the abnormal placenta.Following stabilization and resuscitation, the baby survived and recovered well.
SUGAMMADEX: A NOVEL APPROACH IN THE MANAGEMENT OF ROCURONIUM-INDUCED ANAPHYLAXIS DURING ANESTHESIA INDUCTION
Authors:   Department of Anesthesiology and Intensive Care, Mohammed V Military Hospital, Faculty of Medicine and Pharmacy Mohammed V University Rabat Morocco., Ahtil Redouane , Jidal Marouane ,   Department of Anesthesiology and Intensive Care, Mohammed V Military Hospital, Faculty of Medicine and Pharmacy Mohammed V University Rabat Morocco., Atmani Walid ,   Department of Anesthesiology and Intensive Care, Mohammed V Military Hospital, Faculty of Medicine and Pharmacy Mohammed V University Rabat Morocco., Baadi Tarik ,   Department of Anesthesiology and Intensive Care, Mohammed V Military Hospital, Faculty of Medicine and Pharmacy Mohammed V University Rabat Morocco., Elwali Abderrahmane ,   Department of Anesthesiology and Intensive Care, Mohammed V Military Hospital, Faculty of Medicine and Pharmacy Mohammed V University Rabat Morocco., Bensghir Mustapha ,   Department of Anesthesiology and Intensive Care, Mohammed V Military Hospital, Faculty of Medicine and Pharmacy Mohammed V University Rabat Morocco., Abou Elalaa Khalil ,   Department of Anesthesiology and Intensive Care, Mohammed V Military Hospital, Faculty of Medicine and Pharmacy Mohammed V University Rabat Morocco., Balkhi Hicham ,   Department of Anesthesiology and Intensive Care, Mohammed V Military Hospital, Faculty of Medicine and Pharmacy Mohammed V University Rabat Morocco.
Published: January 2025

Anaphylaxisis a rapid-onset, potentially life-threateningsystemichypersensitivityreaction, with an estimated incidence of 1 in 20,000 anesthetic administrations. Neuromuscularblocking agents (NMBAs), particularlyrocuronium and succinylcholine, are implicatedin 60â€“70% of anestheticanaphylaxis cases. Prompt recognition and intervention are critical in these emergencies. Sugammadex, a selectiveantagonist of rocuronium, offers a noveltherapeuticapproach due to itsability to rapidlyencapsulaterocuroniummolecules, effectivelymitigating the immunologicalprocessesdrivinganaphylaxis. This report presents a 46-year-old womanwhodevelopedrocuronium-inducedanaphylaxisduringcholecystectomy. Manifesting as severe hypotension and urticarialerythemashortlyafter induction, her condition wasunresponsive to initial resuscitativemeasures. Administration of sugammadexpromptlyreversed the reaction, restoringhemodynamicstability and resolvingsymptoms. Allergytestingsubsequentlyconfirmedrocuronium as the causative agent. The discussion explores the pathophysiology, diagnostic challenges, and biochemical investigations pertinent to NMBA-inducedanaphylaxis. A review of the literature supports sugammadex as an emergingtherapeutic option, particularly in refractory cases. This case underscores the necessity of timelydiagnosis and intervention, emphasizingsugammadexsrole in enhancing patient safetyduringanesthesia. Furtherresearch and clinical vigilance are essential to optimizeoutcomes in NMBA-inducedanaphylaxis.
EXPLORING FACTORS AFFECTING FRAUDULENT FINANCIAL REPORTING USING PENTAGON THEORY
Authors: Santoso Kenny , Marlinah Aan
Published: January 2025

This research aims to prove empirical evidence of the influence of fraudulent financial reporting factors with the fraud pentagon model approach, such as Pressure (financial targets, financial stability, external pressure), Opportunity (ineffective monitoring, nature of industry), Rationality (the change of auditors), Capability (change of directors) and Arrogance (the number of CEO’s picture) on fraudulent financial reporting. The sample method of this study used purposive sampling method and produces 213 data or 71 manufacturing companies listed on the Indonesia Stock Exchange (IDX) from 2018 to 2021. The data has been obtained then analyzed using the multiple regression method.. The results of this study prove that external pressure and change of directors has effect on fraudulent financial reporting, while financial targets, financial stability, ineffective monitoring, nature of industry, the change of auditors (KAP), and the number of CEO’s picture have no influence on fraudulent financial reporting. The results of this study have implications for the theory of fraudulent financial reporting by investigating fraud indicators in CrowI's fraud theory or strengthening the Pentagon Fraud Theory. Practical implications, this study has significant implications for auditors, regulators, creditors and shareholders. The findings indicate that external pressure (leverage) and capability (change of directors) can be used to detect fraud in financial statements.
Land use land cover changes from 2003 to 2023 using Remote Sensing and GIS techniques in Niamotpur Upazila with a predictive study for the next decade
Authors:   Department of Environmental Science, Stamford University, Bangladesh, Hossain Nazmul , Adnan Jannatul ,   Department of Chemistry, Chowmuhani Govt. S A College, Bangladesh, Jahin Mim Tasmia ,   Department of Biotechnology, BRAC University, Bangladesh, Binte Zohir Ayesha ,   Department of International Relations, BUP, Bangladesh, Ahmad Iftakhar ,   Department of Zoology, National University, Gazipur, Bangladesh, Zaman Ahmadullah ,   Institutions of Disaster Management, Khulna University of Engineering and Technology, Khulna, Bangladesh, Hasan Mehedi ,   Department of Civil Engineering, Chittagong University of Engineering & Technology, Chittagong, Bangladesh, Hossain Noor ,   Centre for Advanced Research in Sciences (CARS), University of Dhaka, Bangladesh
Published: January 2025

This study aims to examine the temporal dynamics of Niamotpur Upazila, Naogaon District, focusing on Land Use Land cover (LULC) changes over thirty years (2003,2013, and 2023) and providing predictive insights for the next decade (2024÷2033). Utilizing Geographic Information System (GIS) techniques, remote sensing data, and meteorological datasets, we categorize the landscape into five primary land cover types: water bodies, vegetation cover, bare soil, drought-prone areas, and settlement areas. This study investigates the relationship between climatic factors and LULC changes, particularly examining the impacts of precipitation and temperature fluctuations on drought-prone areas. From 2003 to 2023 bare soil consistently decreased, while deep vegetation significantly increased, indicating improved land health. Urban areas and light vegetation peaked in 2013 but declined by 2023. Water bodies decreased until 2013, then increased by 2023. Drought-prone areas saw a drastic decrease in extreme drought and a substantial increase in no-risk areas. Climatic data showed minor fluctuations in average temperatures and precipitation: the average maximum temperature slightly decreased, while minimum temperatures and precipitation had small variations. Predictions for the next decade forecast a gradual rise in the average maximum temperature from 29.758 °C in 2024 to 29.830 °C in 2033. The findings underscore the positive trend of increasing deep vegetation and reducing bare soil, enhancing the region’s ecological health. To address these trends the study offers practical recommendations for policymakers, stakeholders, and local communities. Ultimately, this study gives substantial insights into the relations between the dynamic alterations of LULC and climatic factors and presents a way of achieving a better future environment for Niamotpur Upazila.
Assessing environmental and human health risks of pharmaceutical contamination in surface water
Authors:   National Research and Development Institute for Industrial Ecology ECOIND Bucharest, Cimpean Ioana-Antonia , Chiriac Florentina Laura ,   National Research and Development Institute for Industrial Ecology ECOIND Bucharest, Constantinescu-Groposila Diana ,   University of Agronomic Sciences and Veterinary Medicine of Bucharest, Romania, Cojocaru Victor Constantin ,   National Research and Development Institute for Industrial Ecology ECOIND Bucharest, Iancu Vasile Ion ,   National Research and Development Institute for Industrial Ecology ECOIND Bucharest
Published: January 2025

Pharmaceuticals, also known as medicines, are a mixture of substances used to prevent and treat human or animal diseases or infections. These products are used in many areas, such as medicine, aquaculture, animal husbandry, and, not least, in people’s everyday lives. According to the literature, they are classified into several therapeutic classes, the ones of interest for this paper being non-steroidal anti-inflammatory drugs; antidiabetic drugs, and antacid drugs. The mentioned drugs have raised concerns due to their presence in the environment and the potential health risks they pose. Recently, much research has focused on compounds that have direct harmful effects but are found in the environment at relatively low concentrations. These compounds could seriously threaten aquatic ecosystems, especially in the long term, due to their ability to accumulate in living organisms through bioaccumulation or generate secondary metabolites with harmful side effects. To effectively monitor pharmaceuticals in the environment, it is essential to have a variety of rapid, reliable, and sensitive methods capable of detecting numerous compounds. The most commonly employed techniques include solid phase extraction (SPE) followed by high-performance liquid chromatography coupled with mass spectrometry (HPLC/MS). This study supports ongoing efforts to monitor and regulate drug contamination in water sources, evaluating potential risks to human health and emphasizing the importance of addressing these contaminants to protect environmental and public health.
Evaluating the occurrence of trihalomethanes in drinking water and their implications for human health risk
Authors:   National Research and Development Institute for Industrial Ecology ECOIND Bucharest, Cojocaru Victor Constantin , Petre Valentina Andreea ,   National Research and Development Institute for Industrial Ecology ECOIND Bucharest, Paris Ana Ioana ,   National Research and Development Institute for Industrial Ecology ECOIND Bucharest, Cristea Nicolae Ionut ,   National Research and Development Institute for Industrial Ecology ECOIND Bucharest, Chiriac Florentina Laura ,   National Research and Development Institute for Industrial Ecology ECOIND Bucharest, Cimpean Ioana-Antonia ,   National Research and Development Institute for Industrial Ecology ECOIND Bucharest
Published: January 2025

Trihalomethanes (THMs) are a group of volatile organic compounds that can be easily found in drinking water, especially in municipal water distribution systems supplied by water treatment stations as a result of the chlorination process. This study investigates the THMs presence in various sources across Romania and conducts a human health risk assessment in order to determine the potential danger the population is exposed to. Using a gas-chromatography coupled mass-spectrometry (GC-MS) analysis method, water samples collected over the course of a year were analysed and revealed the cumulative sum of all trihalomethanes (ΣTHMs) saw a maximum concentration of 90.6 µg/L, with an average of 25.6 µg/L and a median of 22.2 µg/L with chloroform and bromoform being the most abundant. The analysis of carcinogenic and non-carcinogenic risks associated with THMs in drinking water reveals women exhibit higher risk levels than men across both categories. The total non-carcinogenic risks for women range from 5.14×10-4 to 4.30×10-1, while for men, the risks range from 4.78×10-4 to 3.78×10-1. Carcinogenic risk assessments indicate a similar trend, with total risks for women varying between 1.37×10-6 and 1.88×10-4, and for men between 2.22×10-7 and 1.66×10-4. comparable values for cancer risk that exceed the minimum or negligible risk threshold established by the USEPA (1.00×10-6).
Indirect electrochemical detection of perfluoro decanoic acid from water
Authors:   National Research and Development Institute for Industrial Ecology ECOIND Timisoara, Negrea Sorina Claudia , Diaconu Lidia Ani , Neidoni Dorian ,   National Research and Development Institute for Industrial Ecology ECOIND Timisoara, Pacala Adina ,   National Research and Development Institute for Industrial Ecology ECOIND Timisoara, Pascu Luoana Florentina ,   National Research and Development Institute for Industrial Ecology ECOIND Bucharest, Motoc Sorina ,   “Coriolan Dragulescu” Institute of Chemistry, Romanian Academy, Baciu Anamaria ,   Politehnica University of Timisoara, Trif Elena ,   Politehnica University of Timisoara, Manea Florica ,   Politehnica University of Timisoara
Published: January 2025

Electrochemical detection of perfluoro decanoic acid (PFDA) has gained significant interest due to the its environmental persistence and potential health risks. This study focuses on the development and utilization of a molecular imprinted polymer (MIP) sensor for the selective and sensitive detection of PFDA in aqueous samples. Commercial boron-doped diamond (BDD) electrode was modified with MIP by electro polymerization in 2:1 (v/v) mixture of 0.1 M sodium acetate buffer solution (pH = 5.8) and methanol containing 10 mM o-phenylenediamine (o-PD) and 1 mM PFDA concentration. The electro polymerization process was carried out using cyclic voltammetry (CV) by scanning 25 cyclic voltammograms in a potential range of 0.00 →1.00 V/SCE with a scan rate of 0.05 V·s-1. The electrochemical performance of the MIP-BDD sensor using cyclic voltammetry (CV), differential pulse voltammetry (DPV) and square wave voltammetry (SWV) was assessed. Considering both voltametric detections based on oxygen reduction reaction (ORR) and the lack of electrochemical activity of PFDA, investigation of its signal in the presence of increased PFDA concentrations is exploited for development of indirect detection method. Linear dependence between signal decrease vs. increasing PFDA concentrations allowed determining sensitivity and the lowest limit of detection of 0.160 nM (0.08 µg·dm-3) PFDA. The integration of MIP technology with electrochemical sensors offers a robust platform for environmental monitoring of PFDA, combining high selectivity, sensitivity and rapid response time. This method holds promise for advancing detection techniques for persistent organic pollutants in environmental and public health contexts.
Effect of Fibrates on Lipoprotein-associated Phospholipase A2 Mass and
Activity: A Systematic Review and Meta-analysis of Controlled Clinical Trials
Authors: Simental-Mendía Luis E. , Simental-Mendía Mario , Gamboa-Gómez Claudia I. , Jamialahmadi Tannaz , Sahebkar Amirhossein
Published: January 2025

Background:

In vascular tissue, macrophages and inflammatory cells produce the enzyme lipoprotein-
associated phospholipase A2 (Lp-PLA2). Treatment with fibrates decreases Lp-PLA2 levels in individuals
with obesity and metabolic syndrome; however, these findings have not been fully clarified.

Objective:

The goal of this study was to investigate the possible effects of fibrate therapy on Lp-PLA2 mass
and activity through a meta-analysis of clinical trials.

Methods:

Web of Science, PubMed, Scopus, Google Scholar, and ClinicalTrials.gov databases were searched
using MeSH terms and keywords. Randomized controlled trials (RCT) evaluating the effect of statins on Lp-
PLA2 mass and/or activity were included in the meta-analysis. Quantitative data were analyzed using a random-
effects model and the generic inverse variance method.

Results:

The meta-analysis of 10 clinical trials indicated that fibrate treatment has no significant effect on Lp-
PLA2 mass (fibrate vs. placebo/nothing = WMD: -3.29 ng/ml, 95% CI: -21.35, 14.78, p = 0.72; fibrate vs. active
control = WMD: -1.08 ng/ml, 95% CI: -51.38, 49.22, p = 0.97); Lp-PLA2 activity (fibrate vs. active control
= WMD: 0.84 nmol/ml/min, 95% CI: -0.17, 1.84, p = 0.10); HDL-LpPLA2 activity (fibrate vs. active control
= WMD: 0.77 nmol/ml/min, 95% CI: -0.33, 1.88, p = 0.17); and secretory PLA2 (fibrate vs. active control
= WMD: 0.37 ng/ml, 95% CI: -1.22, 1.97, p = 0.65). Also, the results of the sensitivity analysis were robust
for all these parameters.

Conclusion:

In conclusion, fibrate therapy did not reduce the mass and activity of Lp-PLA2.
Exploration of Novel Therapeutic Targets for Breast Carcinoma and Molecular
Docking Studies of Anticancer Compound Libraries with Cyclin-dependent
Kinase 4/6 (CDK4/6): A Comprehensive Study of Signalling Pathways for Drug
Repurposing
Authors: Najmi Asim
Published: January 2025

Aims:

This study aims to identify and evaluate promising therapeutic proteins and compounds for
breast cancer treatment through a comprehensive database search and molecular docking analysis.

Background:

Breast cancer (BC), primarily originating from the terminal ductal-lobular unit of the breast, is
the most prevalent form of cancer globally. In 2020, an estimated 2.3 million new cases were reported, resulting
in approximately 685,000 deaths. Mutations in the BRCA1 and BRCA2 genes are well-established in hereditary
breast cancer. The identification of effective therapeutic proteins for BC remains a complex and
evolving area of research.

Objective:

This study aims to identify and evaluate promising therapeutic proteins and compounds specific to
breast cancer through a comprehensive database search and molecular docking analysis.

Methods:

A rigorous search was conducted within the National Cancer Institute (NCI), NCI Metathesaurus,
SIGnaling Network Open Resource (SIGNOR), Human Protein Atlas (HPA), and the Human Phenotype Ontology
(HPO) to shortlist proteins linked to BC (CUI C0678222). Recent studies were reviewed to understand
the administration of CDK4/6 inhibitors (palbociclib, ribociclib, abemaciclib) combined with endocrine therapy
for HR-positive and HER2-negative breast cancer. Anticancer compound libraries available at ZINC and
PubChem were analyzed. Compounds were evaluated based on their binding energies with CDK4 protein, a
rationally selected druggable target.

Results:

Key proteins linked to breast cancer were identified through database searches. Proliferation, apoptosis,
and G1/S transition pathways were frequently found dysregulated in breast cancer. ZINC13152284 exhibited
the strongest binding energy at -10.9 Kcal/mol, followed by ZINC05492794 with a binding energy of
-10.4 Kcal/mol. Preexisting drugs showed lower binding energies with the CDK4 protein.

Conclusion:

The study highlights the importance of drug repurposing as a strategy for the safe and effective
treatment of breast cancer. Synthetic inhibitors often cause severe side effects, emphasizing the need for novel
targets and compounds with better therapeutic profiles. Molecular docking identified promising compounds
from the ZINC database, suggesting potential new avenues for breast cancer therapy.
The Expression Characteristics and Interrelationships of FNDC5 and Pyroptosis-Associated Molecules in the Peripheral Blood of Patients with Coronary Heart Disease
Authors: Pan Yujia , Ou Hangjun , Liu Danan
Published: January 2025

Objectives:

The aim of this study was to investigate the expression characteristics and
interrelationships of FNDC5 and pyroptosis-associated molecules in peripheral blood mononuclear
cells of patients with coronary heart disease (CHD).

Methods:

Patients were divided into stable angina (SA), unstable angina (UA), and acute myocardial
infarction (AMI) groups based on different clinical symptoms. According to the Gensini
score, they were then divided into mild, moderate, and severe lesion groups. The control (NC)
group was also set. ELISA assay was employed to detect the levels of Irisin, IL-1β, and IL-18, and
the levels of pyroptosis-associated molecules, NF-κB p50, NF-κB p65, and FNDC5 were detected
and compared by qRT-PCR and Western blot (WB). Logistic regression and Spearman's partial
correlation analysis were used to analyze the pathogenic factors of CHD and explore the interrelationships
between FNDC5 and the molecules.

Results:

IL-1β and IL-18 of CHD patients were increased, while the Irisin was decreased. With
the aggravation of symptoms and severity of coronary artery stenosis, the former increased, and
the Irisin gradually decreased (P<0.05). About qRT-PCR and WB: With the aggravation of symptoms,
the levels of pyroptosis-associated molecules and other indicators were increased, and FNDC5
was decreased (P<0.05). NLRP3, Caspase-1, and NF-κB p50 protein were positively correlated
with the incidence of CHD, and FNDC5 was also negatively correlated with that of CHD.

Spearman's Partial Correlation Analysis:

Even when common risk factors for CHD were taken
into account, FNDC5 and NLRP3 were still found to be negatively connected.

Conclusion:

The decreased expression level of FNDC5 and the increased level of pyroptosis-associated
molecules may be related to CHD.
Targeting Malaria's Achilles' Heels: A Review of Plasmodium Life Cycle Vulnerabilities for Drug Discovery
Authors: Shukla Shruti , Kushwah Shikha , Mani Ashutosh
Published: January 2025

The global rise of drug-resistant malaria parasites is becoming an increasing threat to
public health, emphasizing the urgent need for the development of new therapeutic strategies. Artimisinin-
based therapies, once the backbone of malaria treatment, are now at risk due to the resistance
developed in parasites. The lack of a universally accessible malaria vaccine exacerbates
this crisis, underscoring the need to explore new antimalarial drugs. A more comprehensive understanding
of the parasites’s life cycle has revealed several promising targets, including enzymes,
transport proteins, and essential metabolic pathways that the parasite relies on for its survival and
proliferation. This review provides an in-depth analysis of the vulnerabilities displayed by Plasmodium
and recent advances that highlight potential drug targets and candidate molecules.
Delineating CYP2C19-Mediated Interactions: Network Pharmacology Investigation of Ilaprazole and Clopidogrel versus Conventional Proton
Pump Inhibitors
Authors: Ananthathandavan Priyadharshini , Narayanasamy Damodharan
Published: January 2025

Background:

Clopidogrel, an antiplatelet drug commonly used in cardiovascular disease,
is metabolized by the liver mainly through CYP2C19. Concomitant use of Proton pump inhibitors
along with clopidogrel may affect the potency of clopidogrel by CYP2C19 inhibition. However, a
novel PPI, ilaprazole is known to differ in its pharmacokinetic features, given the potential differences
between ilaprazole’s interactions and their metabolism with clopidogrel. Network pharmacology investigation
could be a useful tool to evaluate the drug-drug interaction between them.

Methodology:

The molecular structures and targets were retrieved from PubChem and SwissTargetPrediction
to establish the information related to the identified drugs. The possible shared targets
between the clopidogrel and PPIs were explored by a Venn analysis. Subsequently, Protein-Protein
Interaction networks were established using the STRING database. Hub genes were also determined
using the Cytoscape cytoHubba plugin.

Results & Discussion:

Ilaprazole (13.6%) and pantoprazole (13.6%) were characterized by fewer
targets being shared with clopidogrel compared to conventional PPIs (14.9%). Moreover, CYP2C19
was not a hub gene in ilaprazole and pantoprazole interactions, which indicated no significant
CYP2C19 involvement. On the other hand, CYP2C19 functioned as a hub gene in the interactions
with rabeprazole, lansoprazole, dexlansoprazole, omeprazole, and esomeprazole. As a result, patients
receiving pantoprazole and ilaprazole would be at a lower risk for developing adverse cardiovascular
events by maintaining the clopidogrel therapeutic effect.

Conclusion:

The application of the network pharmacology technique allows us to consider the potential
for different effects of PPIs on clopidogrel and its metabolism via CYP2C19. There is a lower
chance of experiencing adverse effects from an interaction between ilaprazole and clopidogrel as
ilaprazole has not been linked to CYP2C19. More research is necessary to confirm these results and
provide clinical guidance for patients undergoing clopidogrel and PPI combination therapy.
Synthesis of Metalopolymer Structure by Potentiostatic Deposition Method
Authors: Yahiaoui Khemissi , khaniche brahim , Touri Farida , Merzouki Soraya
Published: January 2025

The initial fundamental aspect examined in this study pertained to the chemical treatment
of a silicon electrode in an acidic environment. The objective was to facilitate the deposition of organic
or inorganic substances using electrochemical methods. Moreover, this study focused on investigating
the nucleation process of poly(azacyclopenta-2,4-diene) on semiconductor substrates and
exploring the incorporation of copper particles within the resulting film. The deposition of the polymer
film onto the silicon electrode surface occurred through electrochemical oxidation of the monomer
in a Na2SO4/H2O solution. The introduction of copper particles into the polymer film was
achieved through electrochemical reduction in aqueous solutions, leading to the dispersion of metallic
particles within the polymer matrix. Notably, the surface morphology of the poly(azacyclopenta-
2,4-diene)-metal composite films exhibited a coarser and more compact structural appearance compared
to pure poly(azacyclopenta-2,4-diene) films. To gain further insights into the surface characteristics
of the poly(azacyclopenta-2,4-diene) films, EDX analysis confirmed the successful incorporation
of copper into the composite films.
Ultrasound-assisted and Efficient Multicomponent Synthesis of 4H-Pyran Derivatives catalyzed by LiOH.H2O in Water
Authors: Masmoudi Nihel , Chtourou Manef
Published: January 2025

Aim and Objective:

It is well established that 4H-pyran derivatives hold a sig-nificant position in synthetic organic chemistry due to their diverse biological and phar-macological properties. This work aims to introduce a novel synthetic pathway for highly functionalized 4H-pyran derivatives, achieved through a 1,4-Michael addition followed by a cascade cyclization. This reaction is catalyzed by LiOH·H2O under ultrasonic irradiation in water, offering an efficient and environmentally friendly approach.

Materials and Methods:

In this study, lithium hydroxide monohydrate (LiOH·H2O) was used as the catalyst. To explore environmentally friendly methods, two novel approaches utilizing pure water were investigated (Method 1 and Method 2). The first method in-volves the use of alkylidene reagents malononitrile and ethyl acetoacetate in an aqueous medium. The second method features a multi-component cyclocondensation of aromatic aldehydes, malononitrile, and ethyl acetoacetate, activated by ultrasound waves and con-ducted in pure water. The impact of various substituents on the formation of 4H-pyrans, including both electron-poor and electron-rich aromatic aldehydes, was also evaluated.

Results:

Most products were obtained in high yield and as very pure crystals with distinct colors. Generally, aromatic aldehydes with electron-withdrawing groups (Cl) exhibited greater reactivity than those with electron-donating groups (OMe). This trend is clearly demonstrated when comparing entries 3 and 4 with entries 5 and 6 in Tables 1-6.

Conclusion:

Compared to other procedures, this method is simple, fast, eco-compatible since it uses water as a solvent. In addition, the products are obtained in good yields in the pure state after simple recrystallization without the need for other purification techniques, such as column chromatography. These factors make this novel approach highly attractive for the synthesis of 4H-pyrans.
The Exploration of TCM Therapeutic Mechanism as Evidenced by Houpusanwu Decoction on GI Disorders Treatment using Systems Pharmacology
Authors: Wang Shuailong , Zhao Xulong , Li Yan
Published: January 2025

Background:

Gastrointestinal (GI) disorders are a kind of common, but complicated disease
that may be triggered by many factors. In Asia, many traditional Chinese herbs are prominent in
treating GI disorders, but the pharmacological mechanism still remains vague or unknown due to the
multiple-component characteristics of traditional Chinese medicine (TCM).

Objective:

In order to investigate the therapy mechanism of traditional Chinese medicine (TCM) for
Gastrointestinal (GI) diseases, a typical TCM prescription, Houpusanwu Decoction, for the treatment
of ileus, a severe GI disease, is used as a probe presently.

Method:

We performed data mining on all components in Houpusanwu Decoction (HD), established
a corresponding component database, and then conducted ADME screening of potentially active
compounds in the database. Next, we identify potential targets of HD candidate compounds, followed
by the establishment of a series of pharmacological networks. Finally, we conducted SP analysis
and mechanism analysis.

Results:

Through pathway analysis, we found that HD treats ileus mainly through four pathways,
i.e., GI motility-related Calcium, inflammation-related SCF/c-kit and p38/MAPK, and thrombosis
and diabetes-related JAK2/STAT3 signaling pathways, which indicated that HD is a typical prescription
with multichannel and multifunction of TCM characteristics.

Conclusion:

This study not only expounds the pathogenesis of ileus and, at the same time systematically
illuminates the curative mechanism of HD, but also provides a novel SP method to explore the
therapeutic mechanism of TCM in treating complicated GI diseases.
A Current Review on Transdermal Delivery of Protein and Peptides: Possibilities and Challenges
Authors: Thakur Nishant , Thakur Shivani , SINGH YASH PAL , Prasad Sonima , Kaur Bhupinder , Sharma Chandan
Published: January 2025

Transdermal drug administration has become increasingly popular in pharmaceutical research
due to its potential to enhance drug bioavailability, patient compliance, and therapeutic effectiveness.
Transdermal administration of proteins and peptides has proven to be a viable method for
enhancing the therapeutic efficacy and patient adherence to biologic medications. Administering
proteins and peptides through the gastrointestinal route exposes them to stomach acid and enzymes,
causing denaturation and resulting in poor bioavailability. Moreover, to address these issues, various
research groups are focusing on transdermal delivery systems as an alternative route of administration.
Therefore, in this article, we tried to cover the recent developments in formulation strategies,
transdermal delivery systems, and regulatory issues for protein and peptide medicines. The main
approaches for peptide administration, including nanoparticle carriers, biophysical enhancement
techniques, and microneedle-based devices, have been discussed to overcome the difficulties of delivering
macromolecular medications through the skin barrier. Furthermore, we analyse the regulatory
environment that oversees the creation and authorization of transdermal peptide and protein delivery
systems, highlighting the significance of quality control, safety, and efficacy, while also focusing
on clinical advancements and recent research findings.. This review attempts to offer insights delivery
of peptides and proteins. This study focuses on transdermal methods, summarizing recent advancements
in protein and peptide drug delivery. The transdermal route is favored over oral administration
due to its numerous advantages, including non-invasiveness, high patient compliance, and
avoidance of the first-pass effect. Consequently, it highlights the development of an efficient carrier
system that demonstrates these benefits effectively.
Pneumocephalus and Pneumorrhachis Following Titanium Rib Implant: A Case Report and Literature Review
Authors: Koksal Yusuf , Aydin Sefer Burak
Published: January 2025

Introduction:
Pneumocephalus and pneumorrhachis are rare postoperative complications, commonly occurring within a few days to months after spinal surgery.
They are very rarely reported after thoracic surgeries. This case highlights a unique presentation in the emergency department involving headache
and vomiting caused by late complications following thoracic surgery with a titanium rib implant.

Case Presentation:
A 64-year-old male presented to the emergency department with headache and vomiting without fever since prior 1 week. He had a history of left
lower lobectomy and thoracic wall reconstruction with a titanium rib implant 40 days earlier due to epidermoid lung cancer. Computed
tomography imaging of head and thorax revealed bilateral pneumocephalus and extensive pneumorrhachis. After removal of the rib implant and
dural repair, the patient fully recovered.

Conclusion:
This case underscores the importance of early imaging and diagnosis in patients presenting with neurological symptoms following thoracic surgery
and emphasizes the need for enhanced monitoring protocols for patients with titanium implants.
Impact of the Extraction Method and Solvent on the Phenolic Compound Content and Antioxidant Potential of the Aerial Part of Ephedra altissima: In vitro and In silico Studies
Authors: Houhou Dalal , Saad Somia , Menacer Rafik , Ferroudj Sana , Zeraib Azzeddine , Karoune Samira , Fadlaoui Haroun , Bendjemana Katia
Published: January 2025

Background:

Despite the widespread use of Ephedra altissima plant in traditional Algerian
medicine, the biological potential of this species has still not been well explored.

Objective:

This study, for the first time, focused on determining the effect of extraction methods and
solvents on the phenolic content and antioxidant ability of the aerial part of Ephedra altissima.

Methods:

Extraction was carried out by maceration and Soxhlet using the solvents H2O, Methanol/
H2O and Petroleum ether. The chemical profile of E. altissima was determined by a qualitative
HPLC/UV–Visible, and the antioxidant potential was evaluated by in vitro and in-silico studies.

Results:

The aqueous extract obtained by maceration exhibited the greatest total phenol content,
while the petroleum ether prepared by Soxhlet extraction demonstrated the highest total flavonoid
and condensed tannin contents. The HPLC profile showed the presence of a variety of phenolic compounds.
The in-vitro assay results indicated good antioxidant potential. Gallic acid and sinapic acid
were highlighted as the most potent antioxidants in the Soxhlet hydro-methanolic and petroleum
ether extracts, respectively, according to the machine learning model. Molecular docking predicted
the possible antioxidant potential of E. altissima phytocompounds by the interaction with human
peroxiredoxin 5, and epicatechin was the most effective ligand. Molecular dynamics simulations
confirmed the stability of the epicatechin-Prdx5 complex. Multivariate analysis was used to categorize
the Ephedra altissima extracts into three groups according to their phenolic compound content
and in vitro antioxidant ability.

Conclusion:

Overall, the results of the present study revealed that the choice of solvent and extraction
technique directly influence the biomolecule content and bioactivity of Ephedra altissima aerial
part extracts.
Synergistic Anti-tumorigenic Effects of Cabazitaxel and Usnic Acid Combination on
Metastatic Castration-Resistant Prostate Cancer Cells
Authors: Bergel Ceyda Colakoglu , Eryilmaz Isil Ezgi , Bulut Ebrucan , Balaban Rumeysa Fatma , Egeli Unal , Cecener Gulsah
Published: January 2025

Background:

Prostate cancer (PC) affects millions of men, causing high mortality rates. Despite the
treatment approaches, the options for metastatic castration-resistant prostate cancer (mCRPC), a lethal form of
advanced PC, are still limited. Cabazitaxel (Cbx) is the last taxane-derived chemotherapeutic approved for Docetaxel-
resistant mCRPC patients. However, its effects are limited due to the activation of several pathways. Therefore,
new approaches are needed to increase the efficacy of Cbx. Usnic acid (UA) is a natural product with wellknown
anti-tumorigenic and synergistic effects with various chemotherapeutics. Although the cytotoxicity of UA
and Cbx has been evaluated on mCRPC cells, the anti-tumorigenic effect of UA combination with any taxane has
not been investigated yet. Thus, we aimed to evaluate the possible synergistic effect of Cbx+UA in mCRPC cells.

Methods:

Cell viability and apoptosis were analyzed using WST-1 and Annexin-V. Morphological changes were
visualized by fluorescent staining. Finally, cell cycle, mitochondrial health, and ROS levels were determined.

Results:

Based on WST-1 results, 25 μM UA exhibited significant additive and synergistic effects with the use of
Cbx. Annexin V and cell cycle results showed that UA significantly enhanced the Cbx efficacy at increasing
doses compared to using only Cbx (**p<0.01). Moreover, combined treatment significantly increased ROS levels
and mitochondrial membrane depolarization compared with Cbx alone (**p<0.01).

Conclusions:

Thus, the results suggest that UA increased the anti-tumorigenic effects of Cbx on mCRPC cells by
increasing apoptosis, causing an increase in intracellular ROS and disrupting mitochondrial health. Consequently,
combining UA and Cbx offers a new combined therapeutic strategy for mCRPC treatment.
Thrombocytosis in Hemorrhagic Stroke: Case Report and Literature Review
Authors: Kadri Alfansuri , Panggabean Martinova Sari
Published: January 2025

Background

Thrombocytosis is a condition characterized by a platelet count higher than 450,000/μl. In instances of severe thrombocytosis, the number of platelets reaches 1,000,000 per microliter. Thrombocytosis is commonly identified as an unexpected aberration in laboratory tests, as the majority of patients do not show any symptoms. Thrombocytosis can be categorized into two types: essential thrombocytosis (primary) and reactive thrombocytosis (secondary). Reactive thrombocytosis is the predominant form of thrombocytosis. Within the population of persons with thrombocytosis, around 80% to 90% are specifically identified as having reactive thrombocytosis.

Case Presentation

This is a case report of a 73-year-old man who arrived at the emergency room with symptoms, including loss of consciousness, weakness on the right side of his body, high blood pressure, and difficulty breathing. Further investigations have revealed the patient to have a high platelet count (1,186,000/µL), a hemorrhagic stroke, and pneumonia.

Discussion

This case report describes the presence of thrombocytosis in a patient who has experienced a hemorrhagic stroke. The patient displayed a condition of extreme thrombocytosis, marked by a platelet count exceeding 1,000,000 per microliter (µL). The brain CT scan showed a 42 cc intracerebral haemorrhage in the right temporal lobe, resulting in impending obstructive hydrocephalus. The patient also reported experiencing dyspnoea and fever one week prior to hospitalisation, and his sputum culture revealed the presence of Klebsiella pneumoniae bacteria.

Conclusion

This case report demonstrates the clinical presentation of a hemorrhagic stroke accompanied by reactive thrombocytosis, with pneumonia being the major infection linked with reactive thrombocytosis.