bluuebunny/crossref_metadata_2025 huggingface dataset:
The Complete Marbles: Marc Quinn'in İdeal Beden ve Öteki Kavramlarına Katkısı
Authors: Cantekin Yeliz
Published: November 2023

Bu çalışmada İngiliz çağdaş sanatçı Marc Quinn’in ‘The Complete Marbles’ adlı heykel serisi üzerinden, ideal beden algısının dışında kalan beden normları incelenmiştir. Klasik sanat biçimleri incelendiğinde bedenin kusursuz olarak temsil edilme amacı olduğu görülür. Klasik geleneğe bağlı olan Neoklasik sanat örneklerinde de sonsuz güzellik ve kültürel idealizm ehil bedenler aracılığıyla betimlenmiş, ahlaki erdem ve kahramanlık hikayeleri görselleştirilmiştir. Çağdaş sanat ile klasik ideal beden anlayışı kırılmış, ötekileşmiş-dışlanmış olan görünür kılınmaya başlanmıştır. Ampute bedenlerin betimlendiği serideki mermer figürler Neoklasizmin idealize edici tavrına eleştirel bir söylem geliştirmiştir. The Complete Marbles serisi engellilik kavramı üzerinden izleyiciyi sanatsal ve sosyal idealleri sorgulamaya iter. ‘İdeal’ çerçevenin dışında kalanları görünür kılma arzusu, eril dilin yüceleştirdiği estetik ölçütün ve kahramanlık normlarının karşısında alegorik, yeni bir söylem yaratır. Çalışmada The Complete Marbles sergisinde yer alan eserleri aracılığıyla ideal beden kavramının ele alış biçimi incelenmiş, engelli bedenin sanatsal, kamusal alanlardaki görünüş ve algılanış biçimleri ile farklılıkları sorgulanmıştır.
Wokół „Legend tęsknoty” Bolesława Leśmiana
Authors: Filipek Artur
Published: November 2023

Bolesław Leśmian enjoy unflagging popularity this days. Because of that, I tried to revalue Legends of longing, which appeared in researches as a rader modest, early works than valid mile stone in writing practise of Leśmian. To do so, I’ve read them mostly in hermeneutical way.
LOS MOLUSCOS BIVALVOS EN LAS PESQUERIAS CHILENAS
Authors: Osorio Cecilia , Bahamondes Nibaldo
Published: November 2023

Desde tiempos prehistóricos los pueblos que han habitado las actuales costas chilenas han tenido oportunidad de obtener, principalmente en la zona intermareal, un gran número de especias comestibles.
CONTRIBUCIÓN AL ESTUDIO DE LA MERLUZA (Merluccius gayi gayi)
Authors: Guerra Castro Luis
Published: November 2023

Interesa saber la variación que experimenta la materia grasa en diversas especies de pescado de consumo humano a través de un período anual de observación. Los resultados encontrados en este trabajo son de mucha importancia para el estudio de la biología de esta especie e igualmente para complementar otros ensayos de importancia tecnológica. Del punto de vista biológico permitirásacar conclusiones más exactas sobre madurez sexual de esta especie, como del mismo modo relacionar estos datos con problemas más complejos, como son lasmigraciones, alimentación de la especie, etc. Al asociar en un trabajo finaltodos estos datos se podrá determinar áreas de pesca y períodos del año para realizar estas faenas, a objeto de instaurar en base a ellos un plan de fomentopesquero nacional que evite la posible extinción de la especie en referencia.
El fundamento pragmático del Liberalismo Político en Jürgen Habermas
Authors: Grisales Giraldo Juan Camilo
Published: November 2023

Al momento de analizar la propuesta del liberalismo político desde Jürgen Habermas en los textos Las bases morales prepolíticas del Estado Liberal (2004) y Debate sobre el liberalismo político (1998) es importante considerar la construcción del mundo de la vida a partir de la Teoría de la Acción Comunicativa II (1987). Esto con un propósito específico: mostrar cómo surge el acuerdo en la intersubjetividad con base en unos fundamentos normativos tematizados lingüísticamente. Sin embargo, para llegar a esta deducción, se requiere ir a la fuente principal: la fundamentación pragmática del mundo de la vida con los autores Austin, J. (1990) y Searle, J. (199). Así pues, en el presente artículo se pretende relacionar el fundamento pragmático con el liberalismo político desde el autor alemán. Para dicho propósito, se iniciará con el contractualismo de Locke para observar el viraje que se le da a la ley de la naturaleza con el fundamento pragmático. Igualmente, se mostrará la relación con Rawls y la crítica de otros autores a esta postura liberal.
El pirronismo en el argumento de la apuesta de Blaise Pascal
Authors: Caceres Alison
Published: November 2023

El fragmento conocido como "El argumento de la apuesta" (Pascal, 2012, Fr. 418-233) es uno de los más extensos en la obra de Pascal Pensamientos. El diálogo entre un pirrónico y un creyente se debate sobre la conveniencia de apostar a favor de la existencia de Dios. En este trabajo, se propone examinar la presencia del pirrónico en el argumento y considerar cómo Pascal lo aborda. Esta propuesta nos permite analizar un problema ético-religioso y práctico planteado por el francés en el argumento: ¿qué tipo de vida es preferible?, ¿aquella que se sumerge en el pirronismo y, por la suspensión del juicio, no apuesta ni a favor ni en contra de la existencia de Dios, entre otras cosas? O, ¿aquella que apuesta a favor de la existencia de Dios y vive según las costumbres cristianas? A través de este enfoque, defiendo que la presencia del pirrónico en el argumento de la apuesta no puede ser ignorada ni silenciada, ya que desempeña un papel fundamental, aunque no excepcional, en Pensamientos.
Socialização profissional docente e traços identitários de professores seniores em um Programa de Pós-graduação em Ensino de Ciências
Authors: Cremasco Receputi Caian , Machado Hedylady Santiago , Rezende Daisy de Brito
Published: November 2023

O objetivo desta comunicação é o de apresentar parte dos resultados de uma tese de doutorado em andamento que tem o objetivo de identificar as representações sobre orientação acadêmica dos orientadores de um Programa de Pós-graduação Interunidades em Ensino de Ciências da Universidade de São Paulo. A presente pesquisa tem o objetivo de investigar a socialização profissional de orientadores e apresenta cunho qualitativo. Para a obtenção de informações, utilizaram-se entrevistas inspiradas no aporte teórico da história oral, as quais foram analisadas com base na metodologia de análise de conteúdo. Até o momento, foram realizadas oito entrevistas. Destas, quatro foram selecionadas para a análise. Os resultados indicam três elementos de tensão no processo de socialização profissional dos docentes entrevistados: i) o nível de conhecimento que o orientador acredita possuir sobre a área; ii) o sentimento de pertencimento ao grupo visado e as relações interpessoais estabelecidas; e iii) as pressões de produtividade e competitividade próprias do campo universitário.
Semi-Supervised Algorithms
Authors: Nagaraj Ambika
Published: November 2023

Semi-supervised learning, or SSL, falls somewhere between supervised and
unsupervised learning. The algorithm is provided with some supervision data in
addition to unlabeled data. There are two primary learning paradigms in it.
Transductive education aims to use the trained classifier on unlabeled instances
observed during training. This kind of algorithm is mainly used for node embedding on
graphs, like random walks, where the goal is to label the graph's unlabeled nodes at the
training time. Inductive learning aims to develop a classifier that can generalize
unobserved situations during a test. This chapter details different semi-supervised
algorithms in healthcare.
Unsupervised Algorithms
Authors: Nagaraj Ambika
Published: November 2023

The broad term “health care” refers to a system that focuses on improving
medical services to meet the needs of patients. Patients, doctors, vendors, health
companies, and IT companies all work to keep and restore health records in the
healthcare industry. It uses machine learning. Healthcare analysis addresses a variety of
diseases, including cancer, diabetes, stroke, and others. Both the labeled value and the
target value are known. Training the data for unsupervised learning is also involved.
Because the label value is either unknown or absent, it is impossible to evaluate the
model's performance in unsupervised learning. The chapter details different
unsupervised algorithms.
Analisis Pengembangan Desa Wisata Berbasis Penta Helix di Desa Jambu Kabupaten Kediri (Studi pada Desa Wisata Jambu Kabupaten Kediri)
Authors:   Universitas Brawijaya, Oktaviarni Resti
Published: November 2023

The research aims to describe the role of Penta Helix model actors in the development of Agro Petik Kelengkeng, Jambu Tourism Village, Kediri Regency and to describe the supporting and inhibiting factors of the role of Penta Helix model actors in the development of Agro Petik Kelengkeng, Jambu Tourism Village, Kediri Regency. Type of this research is a descriptive and qualitative approach. Data collection techniques are interviews, observations, and documentations. Data analysis used interactive analysis models from Miles, Huberman, and Saldana (2014). The results of the study only four actors in the form of academic, community, media and government played a role in the development of Agro Petik Kelengkeng. The conclusion obtained in the form of Penta Helix actors did not run optimally because there was no role of business actors. Research suggestions are conducting CSR programs, Non-governmental organizations (NGOs) can be involved in the development of Jambu Tourism Village, forming publication media teams, and involvement of Government actors to conduct social media publication training.
The Arsenic Biogeochemical Cycle: A Review
Authors: Martínez López Salvadora , Banegas García Ascensión , Pérez Sirvent Carmen , Martínez Sánchez Maria José , Esteban Abad Maria Angeles
Published: November 2023

This paper reviews the arsenic in the environment. Arsenic contamination is currently one of the leading environmental problems worldwide. The arsenic (As) cycle is the subject of this article because As is an element with a significant impact on living beings and because of its interrelation with other biogeochemical cycles. The biogeochemical cycle of As is closed, so this trace element returns to sediments where it can be changed in its chemical state by micro-organisms present in soils. In addition, some minerals contribute to the sequestration and retention of As. This element interferes with other critical biogeochemical cycles such as sulfur, phosphorus, iron, manganese, and antimony. Another factor to consider is determining the content and interference of organic matter in the soil, as it forms very stable compounds with As. On the other hand, in aquatic environmental conditions, with a high concentration of organic matter and anaerobiosis, a reducing environment is created that facilitates the mobilization of As in the sediments.
Transformation and Articulation of Clinical Data to Understand Students’ and Health Professionals’ Clinical Reasoning: Protocol for a Scoping Review
Authors: Deschênes Marie-France , Fernandez Nicolas , Lechasseur Kathleen , Caty Marie-Ève , Azimzadeh Dina , Mai Tue-Chieu , Lavoie Patrick
Published: November 2023

Background

There are still unanswered questions regarding effective educational strategies to promote the transformation and articulation of clinical data while teaching and learning clinical reasoning. Additionally, understanding how this process can be analyzed and assessed is crucial, particularly considering the rapid growth of natural language processing in artificial intelligence.

Objective

The aim of this study is to map educational strategies to promote the transformation and articulation of clinical data among students and health care professionals and to explore the methods used to assess these individuals’ transformation and articulation of clinical data.

Methods

This scoping review follows the Joanna Briggs Institute framework for scoping reviews and the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) checklist for the analysis. A literature search was performed in November 2022 using 5 databases: CINAHL (EBSCOhost), MEDLINE (Ovid), Embase (Ovid), PsycINFO (Ovid), and Web of Science (Clarivate). The protocol was registered on the Open Science Framework in November 2023. The scoping review will follow the 9-step framework proposed by Peters and colleagues of the Joanna Briggs Institute. A data extraction form has been developed using key themes from the research questions.

Results

After removing duplicates, the initial search yielded 6656 results, and study selection is underway. The extracted data will be qualitatively analyzed and presented in a diagrammatic or tabular form alongside a narrative summary. The review will be completed by February 2024.

Conclusions

By synthesizing the evidence on semantic transformation and articulation of clinical data during clinical reasoning education, this review aims to contribute to the refinement of educational strategies and assessment methods used in academic and continuing education programs. The insights gained from this review will help educators develop more effective semantic approaches for teaching or learning clinical reasoning, as opposed to fragmented, purely symptom-based or probabilistic approaches. Besides, the results may suggest some ways to address challenges related to the assessment of clinical reasoning and ensure that the assessment tasks accurately reflect learners’ developing competencies and educational progress.

International Registered Report Identifier (IRRID)

DERR1-10.2196/50797
Sociodemographic Profile, Health Conditions, and Burden of Informal Caregivers of Older Adults in Brazil During the COVID-19 Pandemic: Cross-Sectional, Exploratory, Noninterventional, Descriptive Study (Preprint)
Authors: Ferreira Pâmela Moraes , Gomes Mateus Cunha , de Araujo Lucianne Nascimento , Oliveira Tainá Sayuri Onuma de , Ferreira Glenda , Aben-Athar Cintia , da Silva Silvio Eder Dias , Cruz Ramos Aline M P , Rodrigues Diego Pereira , Sousa Fabianne
Published: November 2023

BACKGROUND

Demographic changes in the world population have resulted in an increasingly aging society, with a progressive increase in the number of people in situations of dependence, who require assistance from family members to meet their basic needs. Caring for older adults involves performing diverse activities, resulting in reduced free time and tiredness, and fulfilling the demands and expectations related to personal, family, physical, and social life, consequently compromising the quality of life of the caregiver. In this context, the informal caregiver of hospitalized older adults emerges as the focus of attention.

OBJECTIVE

The aim of this study was to describe the sociodemographic profile, health conditions, and burden of informal caregivers of older adults admitted to a university hospital in Brazil during the COVID-19 pandemic period.

METHODS

This is a cross-sectional, descriptive, and analytical study that was conducted with 25 informal caregivers of hospitalized older adults in a university hospital in Brazil between August and September 2022. Three instruments were applied: Caregiver Burden Inventory, sociodemographic questionnaire, and health conditions questionnaire. The data were analyzed using SPSS version 28.0. Descriptive (frequency and percentage) and inferential analyses were performed using 2-sided Student t test with 95% CIs.

RESULTS

Of the 25 interviewees, 18 (72%) were females, 17 (46%) were married or in a stable union, 14 (56%) completed secondary education, and 11 (44%) lived with the older adults who needed care. The average age of the participants was 44 (SD 12.8) years. Regarding their health conditions, most caregivers self-reported it as good (12/25, 48%). They provided care to their father or mother older than 70 years (14/25, 56%). The Caregiver Burden Inventory analysis showed that the caregivers were the most negatively impacted in the domains of personal life overload (mean 10.8, SD 3.46; P=.047) and physical overload (mean 10.6, SD 2.32; P=.02).

CONCLUSIONS

In recent years, there has been an increase in the burden on informal caregivers of hospitalized older adults in Brazil, thereby impacting their personal and physical lives. The findings of our study show that health care professionals should be trained to promote health guidelines and actions to improve the personal and physical lives of the caregiver population in Brazil.
Association of Arterial Stiffness With Mid- to Long-Term Home Blood Pressure Variability in the Electronic Framingham Heart Study: Cohort Study (Preprint)
Authors: Wang Xuzhi , Zhang Yuankai , Pathiravasan Chathurangi H , Ukonu Nene C , Rong Jian , Benjamin Emelia J , McManus David D , Larson Martin G , Vasan Ramachandran S , Hamburg Naomi M , Murabito Joanne M , Liu Chunyu , Mitchell Gary F
Published: November 2023

BACKGROUND

Short-term blood pressure variability (BPV) is associated with arterial stiffness in patients with hypertension. Few studies have examined associations between arterial stiffness and digital home BPV over a mid- to long-term time span, irrespective of underlying hypertension.

OBJECTIVE

This study aims to investigate if arterial stiffness traits were associated with subsequent mid- to long-term home BPV in the electronic Framingham Heart Study (eFHS). We hypothesized that higher arterial stiffness was associated with higher home BPV over up to 1-year follow-up.

METHODS

At a Framingham Heart Study research examination (2016-2019), participants underwent arterial tonometry to acquire measures of arterial stiffness (carotid-femoral pulse wave velocity [CFPWV]; forward pressure wave amplitude [FWA]) and wave reflection (reflection coefficient [RC]). Participants who agreed to enroll in eFHS were provided with a digital blood pressure (BP) cuff to measure home BP weekly over up to 1-year follow-up. Participants with less than 3 weeks of BP readings were excluded. Linear regression models were used to examine associations of arterial measures with average real variability (ARV) of week-to-week home systolic (SBP) and diastolic (DBP) BP adjusting for important covariates. We obtained ARV as an average of the absolute differences of consecutive home BP measurements. ARV considers not only the dispersion of the BP readings around the mean but also the order of BP readings. In addition, ARV is more sensitive to measurement-to-measurement BPV compared with traditional BPV measures.

RESULTS

Among 857 eFHS participants (mean age 54, SD 9 years; 508/857, 59% women; mean SBP/DBP 119/76 mm Hg; 405/857, 47% hypertension), 1 SD increment in FWA was associated with 0.16 (95% CI 0.09-0.23) SD increments in ARV of home SBP and 0.08 (95% CI 0.01-0.15) SD increments in ARV of home DBP; 1 SD increment in RC was associated with 0.14 (95% CI 0.07-0.22) SD increments in ARV of home SBP and 0.11 (95% CI 0.04-0.19) SD increments in ARV of home DBP. After adjusting for important covariates, there was no significant association between CFPWV and ARV of home SBP, and similarly, no significant association existed between CFPWV and ARV of home DBP (P>.05).

CONCLUSIONS

In eFHS, higher FWA and RC were associated with higher mid- to long-term ARV of week-to-week home SBP and DBP over 1-year follow-up in individuals across the BP spectrum. Our findings suggest that higher aortic stiffness and wave reflection are associated with higher week-to-week variation of BP in a home-based setting over a mid- to long-term time span.
3D SCAFFOLDS BY 3D BIOPRINTING
Authors: GADAKH ARCHANA SHANTARAM , KULKARNI ABHIJEET DATTATRAYA
Published: November 2023

When it comes to tissue engineering, 3D printing is a crucial technique for creating intricate constructions using biocompatible materials, cells, and supporting elements. The concept of "3D bioprinting" is concerning 3D printing, which may be used to design personalised implants, paving the way for new bio-manufacturing methods. The method of 3D bioprinting is promising because it can create biomimetic 3D structures that mimic the extracellular matrix and build extremely accurate multifunctional scaffolds with uniform cell distribution for tissue repair and regeneration. The focus of this review is on the 3D printed constructions made from various synthetic and natural materials. With an emphasis on the most recent developments, this study aims to provide an overview of the state-of-the-art field of 3D printing techniques in applications for tissue engineering. An evaluation and overview of using 3D bioprinting, viewpoints of bio-ink, printing technology, and application are presented in this review.
MATERNAL AND FETAL OUTCOMES IN HYPOTHYROID PREGNANT WOMEN: INSIGHTS FROM A HOSPITAL-BASED STUDY IN MANDI, HIMACHAL PRADESH
Authors: DONKA BHARGAVI , MAHAJAN HEMENDER , SHARMA NALNEESH
Published: November 2023

Objective: Thyroid disorders significantly impact maternal and fetal health during pregnancy, with thyroid hormone balance being crucial for fetal development. Hypothyroidism, a common disorder among women of childbearing age, can lead to adverse pregnancy outcomes, including subtle thyroid dysfunction and autoimmune conditions. Diagnosing thyroid disorders in pregnancy is challenging due to overlapping symptoms with normal pregnancy changes and various contributing factors.

Methods: In this prospective observational study conducted in Mandi, Himachal Pradesh, we focused on pregnant women attending the first-trimester antenatal clinic. Inclusion criteria comprised pregnant women aged 18 or older, regardless of their gravidity and parity, who provided informed consent. Exclusions were made for comorbidities such as diabetes, hypertension, renal or liver disease, multifetal gestation, and previous bad obstetric history. A total of 300 hypothyroid pregnant women were selected through convenience sampling. We assessed serum thyroid-stimulating hormone (TSH) levels using chemiluminescent microplate immunoassay (CMIA) and administered adequate L thyroxine treatment to maintain TSH levels below 2.5 mIU/l.

Results: Maternal outcomes exhibited variation, with common delivery methods being cesarean sections (both emergency and elective) and normal vaginal deliveries. Some pregnancies faced complications, including gestational diabetes mellitus, preterm birth, and placenta previa. Neonatal outcomes ranged from healthy newborns to those with low Apgar scores, intrauterine demise, low birth weight, and stillbirth. Adequate treatment with L thyroxine was observed in 60.6% of cases, emphasizing the need for improved hypothyroidism management during pregnancy.

Conclusion: Our study underscores the diversity of maternal and neonatal outcomes associated with hypothyroidism during pregnancy in a hilly region of India. Early detection, comprehensive antenatal care, and optimal thyroid hormone management are vital to minimize complications and promote the well-being of both mothers and newborns. Further research and awareness campaigns are essential for enhancing thyroid disorder screening and management in pregnancy.
EXPLORING THE POTENTIAL OF 3D PRINTING IN PHARMACEUTICAL DEVELOPMENT
Authors: KURIL ANJALI , AMBEKAR ANJU , NIMASE BHARATI , GIRI PRACHI , NIKAM PRAJWAL , DESAI HARITA , AHER SHUBHANGI
Published: November 2023

Pharmaceuticals have been transformed by additive manufacturing, often known as three-dimensional printing (3DP) a disruptive technology. The concept of additive manufacturing is examined, with a focus on its potential for quick prototyping, cost savings, and development of customized medicines. In the pharmaceutical industry 3DP is used to develop numerous dosage forms and drug delivery systems including oral films, controlled-release tablets and transdermal patches. It also makes it possible to produce specialized medical prosthetics, implants and gadgets. The applications of various 3DP types such as material extrusion, material jetting, binder jet printing and powder-based procedures like selective laser sintering, are thoroughly covered. This review assesses the compatibility of the common 3DP materials for pharmaceutical applications including hydroxypropyl methylcellulose, hydroxypropyl cellulose, Carbopol and Eudragit. This review article forecasts 3DP prospects and shortcomings. The technology's continued development and use in the pharmaceutical industry and other industries will depend on overcoming regulatory challenges, creating standardized procedures and optimizing material alternatives. By tackling these issues 3DP has a great deal of potential to revolutionize personalized medicine, medical device production and variety of other industries ultimately leading to better patient outcomes and healthcare solutions. Types and principles, materials, applications, scalability, regulatory compliance and potential future challenges are discussed in this review paper.
EXPLORING THE QUALITY OF LIFE OF PARENTS AND SIBLINGS OF CHILDREN WITH CEREBRAL PALSY: IMPLICATIONS FOR CAREGIVING AND SUPPORT
Authors: KOTIYA VIDHI , CHOUDHARY RICHA , YADAV ANJU
Published: November 2023

Objective: This study aimed to explore the quality of life (QOL) of parents and siblings of children with cerebral palsy (CP) and its implications for caregiving and support.

Methods: A hospital-based cross-sectional descriptive study was conducted in the Department of Pediatrics, S. P. M. C. H. I. Hospital, SMS Medical College, Jaipur, India, from March 2021 to December 2021. Parents and siblings of children with CP, aged 2-12 y, were enrolled. The World Health Organization Quality of Life-BREF (WHOQOL-BREF) questionnaire was used to assess QOL. Data analysis was performed using descriptive statistics and SPSS software.

Results: The study included 100 parents and siblings of children with CP. Most children had normal birth weight and were born at term. Spastic quadriplegia was the most common type of CP observed. More than half of the children had other medical conditions, with epilepsy being the most prevalent. WHO-QOL BREF scores were low across all domains. Physical domain was the most affected (9.97±2.15), followed by Social interaction domain (10.48±2.32) and psychological domain (10.83±2.26) and Environment domain (11±2.23). The age and gender of the child, severity of disability, education of caretakers, family type, socioeconomic status, chronic illness did not significantly impact the QOL of caregivers. Caregivers with impaired functional status reported lower QOL scores. Meeting scheduled appointments positively influenced caregivers' physical and environmental domain scores.

Conclusion: The caregivers of children with CP experience lower quality of life and high levels of stress. If sustained over time it can affect family dynamics and quality of care provided to such children with CP. The implications of these findings can guide the development of targeted interventions and support programs for caregivers of children with CP.
DEVELOPMENT OF EFINACONAZOLE NAIL GEL FOR THE TREATMENT OF ONCHOMYCOSIS
Authors: SUNDARI IVATURI BALA TRIPURA , KALVA SIREESHA , BINDU MALAVIKA
Published: November 2023

Objective: The present research has been undertaken with the aim to develop a topical nail gel formulation of Efinaconazole. Efinaconazole is considered highly desirable to treat common nail disorders such as Onychomycosis due to localized effects and improved adherence. Efinaconazole topical gel preparations are not yet available in the market thus, this formulation is made for better patient compliance. Efinaconazole nail gel is formulated with unique ingredients added to an alcohol-based formulation to provide low surface tension and good wetting properties.

Methods: The nail gels were formulated by using different gelling agents. Various formulations [F1-F10] were developed using a suitable polymer [Carbopol-934, Xanthan gum, CMC]. The formulations were evaluated for pH, viscosity, spreadability, % Drug content, extrudability, stability testing, in vitro drug diffusion studies, and in vitro antifungal activity.

Results: The results showed that Efinaconazole nail gel had good antifungal activity. Viscosity studies and pH studies revealed that formulation F2 was better when compared to other formulations. Results indicate that the 0.75% concentration of carbopol-934 is the ideal among other formulations.

Conclusion: It was concluded that formulation F2, containing a 0.75% concentration of Carbopol-934 was the best formulation of all.
A COMPREHENSIVE STUDY OF RECENT BREAKTHROUGHS IN THE MANAGEMENT OF DYNAMIC VIRAL INFECTIONS
Authors: SHARMA ROMA , SINGH SURABHI
Published: November 2023

Infectious diseases have been known to human civilization since the dawn of humanity. Infectious disorders are caused by various microorganisms (bacteria, fungi, and viruses). Viruses are the most well-known of all microbes. Viruses are the most well-known type of microbe. They are ultramicroscopic intracellular parasites that require a host cell to survive and reproduce. Viruses have either DNA or RNA as genetic material and have been linked to various diseases in humans, animals, and plants. The war between viruses and humans is ongoing, as both will employ diverse ways to oppose each other. Antiviral treatment and improved technology development a time-consuming process. Despite advanced instruments and tight quality control systems, only a few numbers of antiviral medications or treatment technologies are approved for human use. The cause could be side effects or antiviral medication resistance. Increased understanding of viruses, their infection mechanisms, and the rapid evolution of novel antiviral methods and methodologies will accelerate the creation of novel antiviral medications. This review focuses on the worldwide picture of drug discovery for infectious diseases and contemporary improved methodologies and antiviral therapy options.
Adaptación de una tarea de descuento temporal con estímulos alimentarios
Authors: Ruiz Acacio Emmanuel Alfredo , Silva Gutiérrez Cecilia
Published: November 2023

Objetivo: probar la utilidad de la tarea de descuento temporal de Koffarnus y Bickel (2014) al sustituir los estímulos neutros por alimentarios.
Diseño metodológico: se trata de un estudio instrumental de corte transversal y alcance descriptivo. Se realizó una traducción y retraducción de los reactivos, se integró la imagen de dos barras de chocolate, se modificó la consigna de “preferirías tener” a “preferirías comer” y se realizó una prueba piloto. Posteriormente se aplicó a una muestra de 191 participantes de entre 18 y 30 años (M= 22.33, DE= 4.02) residentes de la Ciudad de México, 121 mujeres y 70 hombres.
Resultados: se encontró una tendencia de los participantes a descontar más las recompensas retardadas. La tasa de descuento mostró un comportamiento similar al reportado en la literatura (k = .25, s= .24, R2 = .62; k = .014, s= .87, R2 = .90), lo que indica que la tarea sí permite identificar la tendencia a descontar las recompensas.
Limitaciones de la investigación: la utilización de un solo estímulo alimentario es limitante, así como la presencia de sensación de hambre y la no diferenciación de estímulos dulce y salado. Sin embargo, esto no impide que se obtenga una medida de descuento temporal acorde con el reportado en la literatura.
Hallazgos: la tarea sí es capaz de identificar la tendencia a descontar las recompensas retardadas, además se pudieron obtener los valores de área bajo la curva para ambas condiciones lo cual permite establecer que la tarea es adecuada para obtener una medida del DT.
Violencia familiar
Authors: Chávez Carapia Julia del Carmen
Published: November 2023

Este primer volumen de la serie de Cuaderno de Investigación del Centro de Estudios de la Mujer está dedicado a la Violencia Familiar, tema tan actual hoy que enfrenta grandes retos, ya que no se trata de un fenómeno local ni federal sino nacional e internacional, y fundamentalmente es un problema de género y de cultura social. La violencia familiar se vivía como parte de la vida cotidiana, en el mundo de lo privado, al interior del hogar, en las relaciones y dinámicas familiares, como una relación de autoridad de los ho9mbres sobre las mujeres, y de dependencia de las mujeres hacia los hombres, de la esposa hacia el marido y de los hijos hacia los padres. Como resultado del surgimiento de los derechos sociales y humanos, y de su ejercicio civil, los individuos adquieren una personalidad social y se convierten en sujetos que exigen sus derechos. Sin embargo todavía existen conductas privadas que se muestran en contra de los derechos mencionados y que poco se demandas en el ámbito público; este es el caso de la violencia familia, que atenta contra la esencia humana, la tolerancia, el respeto, la dignidad, los derechos ciudadanos y la libertad.
Personas con discapacidad y privados de su libertad en la Ciudad de México. Un estadístico de siete centros penitenciarios
Authors: Pérez Ramírez Berenice
Published: November 2023

En el encierro se pone en duda el estatus del sujeto, no sólo en el sentido de que pierde el derecho a ser reconocido como ciudadano, sino que la imagen del sujeto se distorsiona ante la etiqueta de criminal. En este contexto y aunado a la política punitiva, se indagó cómo se produce ahí la “discapacidad”, qué dicen los sujetos acerca de su experiencia con relación a las posibles dificultades y limitaciones que enfrentan y, finalmente, ideas comprensivas de lo que se encontró en las conversaciones e ingresos a los centros penitenciarios. Por lo que se buscó conocer la situación y condiciones en las que se encontraban las personas con “discapacidad” que están privadas de su libertad en 7 centros penitenciarios de la Ciudad de México. Presentándose datos generales de las personas que accedieron a responder las preguntas, el grado de dificultad en actividades básicas, redes de apoyo, los tipos de apoyo, actividades que realizan, uso de sustancias y su desempeño de sus actividades.
Cognitive Diagnostic Assessment with Supervised Learning Using Bayesian-based Data Augmentation
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Yoon Ji-young , Kim Rae Yeong , Yoo Yun Joo
Published: November 2023

Objectives The purposes of this study were to propose and validate a method for applying supervised learning for cognitive diagnostic assessment by augmenting expert-labeled dataset using Bayesian parameter estimation techniques.
Methods The method was evaluated with a simulation study and an application to real data. The simulation study was conducted to compare the diagnostic accuracy of neural networks trained with both ‘Bayesian-based aug-mented dataset’ and ‘expert-labeled dataset’ across four factors: ‘item quality’, ‘expert labeling error rate’, ‘size of the expert labeled dataset’, and ‘size of the augmented dataset’. Additionally, the real data consists of the binary responses of 936 middle-school students to 24 arithmetic problems on linear equations and linear inequalities.
Results The performance of supervised learning trained on the ‘Bayesian-based augmented dataset’ showed significant improvements in all conditions compared to solely using the ‘expert-labeled dataset’. The effect of the labeling error rate and the size of the expert-labeled dataset was trivial. As the quality of the items increased and the size of the augmented dataset grew, accuracy improved, though beyond a certain size N=3,000 of the aug-mented dataset, the difference was negligible. For the real data on linear equations and inequalities, supervised learning trained on the ‘Bayesian-based augmented dataset’ showed enhanced accuracy over just on the ‘ex-pert-labeled dataset’. It is also evident that students understand solving linear equations better than solving linear inequalities.
Conclusions When performing supervised learning based cognitive diagnosis with a small expert-labeled data-set, the diagnostic performance can be enhanced through Bayesian-based data augmentation method. Moreover, students tend to find understanding inequalities more challenging than equations, suggesting the need for opportunities to master cognitive attributes related to inequalities.
FOTOĞRAF SANATINDA BİR SOYUTLAMA ESTETİĞİ OLARAK FOTOGRAM
Authors: BİRİNCİ Gökhan , YENİPAZARLI Gözde
Published: November 2023

19.yy. da bulunuşundan günümüze kadar geçen süreçte fotoğraf, birçok teknik uygulamalar ile kendini yenileyen ve dönüştüren bir sanat dalıdır. Fotogram tekniği bu uygulamalardan biridir. Fotogram, kamerasız bir tekniktir ve ışığa duyarlı bir malzeme üzerine yerleştirilmiş nesnelerin birebir soyutlanmış temsilini üretir. Fotoğraf makinası olmadan fotoğraf üretme tekniği olan fotogram yöntemi, bu yeni ifade aracını keşfeden sanatçılar için heyecan kaynağı olmuştur. Fotogramın kendine ait tekniği sanatçıların kendi kişisel üslupları ile birleşip bir anlatım dili haline gelmiştir. Bu teknik; sanatçılar tarafından 1900’lü yılların başından itibaren bir deneysel dışavurum gibi görünmüş olsa da günümüzde bireysel ve özgün çalışmalar olarak yeniden karşımıza çıkmaktadır. Bu araştırmanın amacı, analog fotoğraf süreci içerisinde kendini var eden bu tekniğin dijital çağ ile birlikte geçirdiği dönüşümü saptamaktır. Bu amacı gerçekleştirmek için fotoğraf tarihinden referanslar belirlenmiş ve bu referanslar üzerinden analizler gerçekleştirilmiştir. Araştırmanın temel bulgusu, fotogram tekniğinin başlangıçtan günümüze bir yandan uygulama alan ve araçları diğer yandan içerik bağlamında nasıl bir değişim gösterdiğinin saptanması olmuştur.
KAVRAMSAL SANAT PRATİĞİ; “ŞEY” VE DÜŞÜNCE ÜZERİNE
Authors: TARLAKAZAN Elif , TARLAKAZAN Burak Erhan
Published: November 2023

Tarihsel okumada 1960-1970 yılları arasında zirveye ulaşan bir hareket olarak “Kavramsal Sanatın”; Dadaizm, Sürrealizm, Süprematizm, Soyut Dışavurumculuk ve Fluxus gibi yirminci yüzyıl sanat hareketlerinin ve sanatın özgür olma tutkusunun özümsenmesiyle hayat bulmuştur. Temel amacı güzel veya estetik açıdan hoş bir şey üretmek olmayan bu sanat hareketine göre “sanat”; bizi düşündürmüyorsa gereksizdir. Aynı zamanda sanatsal ifade araçlarının sonsuz olduğu, sorgulamaya ve tartışmaya açık konuların sınırsız olduğu söylemi genel vizyon ve ortak paydadır. Sanatta kavramsallık; eserin fiziksel formunun ötesinde sanatçının ne anlatmaya çalıştığının algılanmasına yönelik bir süreçtir. Kavramsal sanat üretiminde sanatçılar sanatın sınırlarını sorgulamaya başlamışlar, bu sorgulamaların ilerleyişi, etkileri ve çıktıları kavramsal sanatın ortaya çıkmasına yol açmıştır. Çalışmada, nitel araştırma yöntemlerinden - araştırılması hedeflenen olgu veya olgular hakkında bilgi içeren yazılı materyallerin analizini kapsayan- doküman incelemesi kullanılmış, düşünce-“şey”de yaratıcılık ve kavramsal sanatın önemi üzerinde durulmuştur. Sonuç itibariyle, 60-70’li yıllara takvimlenen kavramsal sanat için; eleştiri yapabilme, tanıma, soru sorma, söylenmeyeni dile getirme konusunda günümüz sanatını etkilediği ve bu yolda sanat üreten bireylere katkı sağladığı görülmüştür.
HİTİT MÜZİĞİ DİZİLERİ İLE TÜRK MÜZİĞİ DİZİLERİNİN ‘ARALIK’ ESASINA GÖRE KARŞILAŞTIRMALI ANALİZİ
Authors: PELİKOĞLU Mehmet Can , AKARSU Sedat Selçuk
Published: November 2023

Bu çalışmada, Anadolu coğrafyasında M.Ö. 1650-1190 yıları arasında varlık göstermiş Hitit uygarlığı hakkında günümüze ulaşmış kaynaklardan tespit edilmiş Hitit müziği dizileri ile Türk Makam müziğinde kullanılan dizilerin karşılaştırılması amaçlanmıştır.

Araştırmada aşamalı olarak; betimsel araştırma yöntemi, belgesel tarama modeli kullanılmıştır. Her iki müzik türünün dizilerinin karşılaştırılmasında, özgün yapıyı belirleyici ve ayırt edici kıldığından ‘aralık’ kavramına odaklanılmıştır. Hitit müziği dizileri çalgı ile seslendirilerek o dizi içerisindeki melodik işleyişin kulakta bıraktığı makam hissi ve makam etkisi konunun uzmanı kişilerin görüşü de alınarak değerlendirilmiştir. Türk Makam müziğinde kullanılan diziler ile Hitit müziği dizilerinin karşılaştırılmalı sistemsel analizi yoluyla benzer ve farklı yönleri ortaya konulmaya çalışılmıştır

Elde edilen bulgulara göre toplamda yedi (7) Hitit dizisi tespit edilmiştir. Bu diziler inici çıkıcı şekillerine göre Türk müziği dizileri ile karşılaştırılmıştır. Hitit dizilerinin bazılarının inici halleri ile çıkıcı hallerinin Türk müziğinde farklı makam dizilerine karşılık geldiği görülmüştür. Tespit edilen makamların “Kürdi, Muhayyer Kürdi, Buselik, Çargâh ve Segâh” makam dizileri ile benzer olduğu sonucuna varılmıştır.
Produções narrativas na formação por alternância: um estudo de caso com estudante da licenciatura em educação do campo
Authors: Santos Marcelo Loures , Queiroz do Prado Daniela
Published: November 2023

As licenciaturas em Educação do Campo têm como objetivo formar professores e gestores para atuarem por áreas de conhecimento em escolas situadas no campo. Orientadas pelos princípios da Formação por alternância, esse modelo educacional pressupõe planejamento, estudos e levantamento de informações na comunidade e sua socialização entre educandos e professores. Buscamos discutir as similaridades teórico-metodológicas entre a Formação por alternância, a Metodologia das Produções Narrativas e sua aplicação em estudo de caso com uma estudante do curso de Licenciatura em Educação do Campo da Universidade Federal de Viçosa. Foram realizadas entrevistas narrativas sobre os territórios educativos em sua comunidade, refletindo a trajetória pessoal, história local e contexto nacional. A Metodologia das Produções Narrativas contribui para recuperar diferentes sentidos da experiência educativa, compreender as vicissitudes da educação do campo e atualizar experiências enquanto sujeito do campo.
Experiência em dança na formação de professores
Authors: Ferreira Luciana Haddad , Takahachi Victoria Ramos
Published: November 2023

O trabalho se insere no campo da formação continuada docente, com foco na experiência estética, e tem como objeto de estudo as contribuições da experiência em dança na formação de professores. Partindo de indagações sobre seu percurso formativo, a pesquisadora-dançarina troca cartas com colegas de profissão que também tiveram sua trajetória marcada pela dança. A pesquisa tem como objetivo compreender as contribuições da prática da dança para a formação docente e refletir sobre a experiência estética como produtora de sentidos do ser professora. As cartas trocadas foram analisadas com base no paradigma indiciário, buscando suporte no referencial teórico da teoria Histórico-Cultural. Como eixos de análise, destacam-se a dança como: forma de expressão; processo de criação; percepção de si e do outro. A pesquisa aponta para a urgência de se pensar em práticas formativas pautadas na arte, que valorizem os contextos, as trajetórias de vida e os saberes produzidos coletivamente.
Thinking the Anthropocene against the Backdrop of Armed Conflict: Territory as a Place for Cognitive Production, Affective Participation, and Discursive Imagination
Authors: Bashizi Anuarite , Ocampo Angela , Hecquet Corentin , Nyenyezi Aymar , De Nanteuil Matthieu
Published: November 2023

This article reflects on the Anthropocene against the backdrop of armed conflict. To this end, it analyses two mining projects: one in southwestern Antioquia in Colombia and the other in the Luhwindja Chiefdom in the Democratic Republic of Congo. After examining the post-agreement and post-war political contexts of each country, this paper describes the extraction projects implemented in the territories, as well as the forms of resistance of the local populations. It also depicts the reconstruction of the territory as a place for cognitive production, affective participation, and discursive imagination. The very concept of territory is re-signified, beyond its geographical definition, as a territory of life.
Do Social Isolation and Loneliness Affect Healthcare Spending and Utilization in Japan?
Authors: Yüksel Üsame Furkan
Published: November 2023

Social isolation and loneliness are associated with worse health outcomes, and there is a growing literature that studies the economic cost of these conditions in terms of increased healthcare spending and utilization. However, a handful of existing studies mostly focus on Western countries. This article analyses the issue in the case of Japan using the Japanese Study of Aging and Retirement (JSTAR) dataset with the help of generalized linear and probit models. The results show that social isolation is associated with reduced healthcare spending, while loneliness does not have any statistically significant effect. Neither social isolation (living alone) nor loneliness has a statistically significant effect on healthcare utilization; that is, these measures are not associated with increased or decreased inpatient or outpatient visits. Therefore, care should be taken when launching social programs to tackle social isolation and loneliness to reduce healthcare spending and utilization because these two conditions might not be associated with increased healthcare spending universally.
A PMU-Based Island Detection Technique Validated by a Real-Case Study of a Distribution System in Malaysia
Authors: Arefin Ahmed Amirul , Hasan Khairul Nisak Binti Md
Published: November 2023

Islanding detection is becoming a vital aspect of the power system as
the penetration of distributed generators in the utility power system
continues to grow. If the distribution generation (DG) capacity matches
the connected feeder load the islanding detection takes longer due to
the minimal power imbalance between the DG and the utilities prior to
islanding event. This research work proposes a slip and acceleration
angle-based islanding detection algorithm using phasor measurement unit
(PMU) voltage angle data. Specifically, this research utilizes the grid
and DG bus voltage angles in the form of their slip and acceleration
angle parameters. This research work presents the performance results of
the proposed islanding detection algorithm for the under frequency, over
frequency, and match frequency islanding conditions. The proposed
algorithm is developed using IEEE 30 bus system and validate with the
actual Utility Kerteh system (located in Terengganu, Malaysia) based on
simulated PMU voltage angle data for 8 different island and non-island
cases. Notably, the proposed algorithm shows that it can detect all
islanding conditions of the Utility Kerteh system at 20ms, which means
it requires only one cycle duration after island incepts in the network.
Uma abordagem MCDA para identificar relações-chave entre estados de saúde de esclerose múltipla
Authors: Sallum Frederico Silva Valentim
Published: November 2023

Objetivo: Identificar relações-chave entre estados de saúde nas cadeias de Markov de dois grupos de pacientes de esclerose múltipla não tratados: menores de 28 anos; e com 28 anos ou mais. Em seguida, este estudo busca observar se as relações-chave identificadas entre os estados de saúde nos dois grupos são as mesmas. Métodos: As cadeias de Markov geradas por Palace et al. para esclerose múltipla em 10 estados de saúde por ciclos anuais para os dois grupos citados acima, foram utilizadas para identificar as relações-chave entre estes estados através de uma abordagem do campo de estudo da análise de decisão multicritério (MCDA; multi-criteria decision analysis). Resultados: Foram identificadas 34 relações-chave iguais em ambos os grupos de pacientes. No entanto, apenas para o grupo de pacientes menores de 28 anos foi identificada a relação-chave de transição do estado de saúde #6 para o estado de saúde #8 e a relação-chave de transição do estado de saúde #8 para o estado de saúde #9. Conclusão: A abordagem MCDA aqui apresentada mostrou uma forma de identificar relações-chave entre estados de saúde em cadeias de Markov. Este estudo demonstrou que o risco de progredir em esclerose múltipla do estado de saúde #6 para o estado de saúde #8 e progredir do estado de saúde #8 para o estado de saúde #9 pode ser maior no grupo de pacientes de esclerose múltipla não tratados menores de 28 anos do que no grupo de pacientes com 28 anos ou mais, através de uma abordagem MCDA.