bluuebunny/crossref_metadata_2025 huggingface dataset:
Autoestima e coping espiritual - religioso de mulheres com câncer de mama: análise reflexiva
Authors: Andrade João Vitor , Bonifácio Rafael Guimarães , Souza Juliana Cristina Martins de , Terra Fábio de Souza
Published: November 2024

Introdução: o câncer de mama, sendo a segunda maior causa de mortalidade global, representa um desafio significativo para a saúde pública, com o diagnóstico precoce sendo crucial para melhores prognósticos. Diante dos múltiplos sintomas e desafios biopsicossociais enfrentados por mulheres em tratamento, incluindo o impacto na autoestima e a adoção de estratégias de coping espiritual-religioso, este estudo busca investigar a interação desses construtos na experiência das pacientes. Materiais e Métodos: utilizaram-se os descritores “Adaptation, Psychologica”, “Self Concept”, “Breast Neoplasms”, e as palavras-chaves “Breast Cancer”, “Spiritual Coping - Religious”, “Self-Esteem”, nos idiomas português, inglês e espanhol. Resultados: o Câncer de mama impacta as múltiplas dimensões da vida da mulher, podendo afetar a autoestima dessas mulheres, e consequentemente, acarretando prejuízos à qualidade de vida. Aponta-se ainda, que o coping espiritual - religioso nas mulheres que vivenciam o câncer de mama, pode variar, sendo que, quando o coping é negativo, também se relaciona à perda da qualidade de vida. Conclusão: frente ao impacto do câncer de mama desde seu diagnostico as múltiplas dimensões da vida da mulher, destaca-se a importância da autoestima elevada e do coping espiritual - religiosos positivos para mulheres com câncer de mama.
Palavras-Chave: Neoplasias da Mama; Autoimagem; Adaptação Psicológica; Qualidade de Vida.
Repercussões das cicatrizes de queimaduras em crianças: protocolo de revisão de escopo
Authors: Batista Francieli Ferreira de Andrade , Bolorino Natacha , Zampar Elisângela Flauzino , Pimenta Rosângela Aparecida
Published: November 2024

Introdução: O presente protocolo tem como objetivo descrever a sistematização do desenvolvimento de uma revisão de escopo que terá como objetivo sintetizar as produções cientifica sobre as repercussões das cicatrizes de queimaduras em crianças. Material e métodos: Será fundamentado pela metodologia proposta pelo Joanna Briggs Institute no Manual for Evidence Synthesis e recomendações do Preferred Reporting Items for Systematic and Meta-Analyses - Extension for Scoping Reviews. A pergunta de revisão foi elaborada conforme o acrônimo PCC: Quais as evidências científicas sobre as repercussões de cicatrizes (conceito) em crianças que sofreram queimaduras (população)? A busca pelos registros será conduzida nas principais bases de dados de ciências da saúde Medical Literature Analysis and Retrievel System Online, Web of Science, Scopus, Literatura Latino-Americana e do Caribe em Ciências da Saúde, Embase, Psycinfo, repositórios de dados da literatura cinzenta catálogo de teses e dissertações da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior e Google Acadêmico. Para a seleção, procederá a leitura de título e resumo seguida pela leitura na íntegra com aplicação dos critérios de inclusão por uma dupla de pesquisadores e se houver divergências um terceiro pesquisador será consultado. Resultados: Os dados serão extraídos por um instrumento elaborado pelos pesquisadores. Os resultados serão apresentados em quadros. Considerações finais: Espera-se com essa revisão encontrar evidências que possibilitem a melhor compreensão sobre as repercussões das cicatrizes de queimaduras em crianças visto ser um dos principais períodos que ocorre o estirão do crescimento e do desenvolvimento humano.
Palavras-Chave: Criança; Cicatriz; Queimaduras; Crescimento e Desenvolvimento; Qualidade de Vida; Revisão de Escopo.
Reificação na saúde: impedimento para uma visão humanizada no sistema de saúde
Authors: Pinto Lucas Soares Diniz , Silva Rose Mary Costa Rosa Andrade , Pereira Eliane Ramos , Moura Verônica Bessa de Paulo de
Published: November 2024

Introdução: este artigo pretende compreender a percepção dos acadêmicos de enfermagem sobre a reificação na saúde e suas consequências no contexto da humanização do Sistema Único de Saúde. Método: foi realizado estudo qualitativo fenomenológico com base na fenomenologia de Maurice Merleau-Ponty. Assim, foram realizadas 30 entrevistas fenomenológicas para compreender as percepções de acadêmicos de enfermagem do 8º e 9º períodos de graduação de uma universidade federal brasileira. Resultados e Discussão: obtiveram-se três categorias que se referem à percepção do graduando de enfermagem acerca das implicações e exemplos da reificação, e nove unidades de significado, onde se escolheu uma para análise nesta pesquisa: o comprometimento da humanização. Nesta unidade de significado, compreendeu-se que os acadêmicos identificam a reificação enquanto fenômeno engessador, mecanizador e promotor de ações desumanizadoras. Considerações Finais: por se tratar de um fenômeno que prejudica as relações sociais e gera afastamento entre os sujeitos, principalmente no contexto saúde, é preciso atentar-se à reificação como um aspecto importante para o ensino, pesquisa e formulação das ações em saúde.
Palavras-chave: Reificação; Estudantes de Enfermagem; Percepção; Humanização da Assistência.
Conhecimento nutricional, estado nutricional e risco metabólico em caminhoneiros que trafegam na BR 116 do Sudoeste da Bahia
Authors: Brito Alane , Cayres Elaine Martins Pinto , Lelis Clara Oliveira , Santos Maria da Conceição Quirino dos , Yarid Sérgio Donha
Published: November 2024

Objetivo: investigar o conhecimento nutricional, bem como avaliar o estado nutricional e o risco metabólico de caminhoneiros que trafegam na BR 116. Métodos: trata-se de um estudo do tipo descritivo, transversal e quantitativo, realizado no mês de setembro de 2023 com 84 caminhoneiros brasileiros do gênero masculino, maiores de 18 anos. A coleta de dados ocorreu no espaço da fiscalizadora da Polícia Rodoviária Federal (PRF) na BR 116, entre as cidades de Jequié e Vitória da Conquista. Resultados: a amostra foi composta por 84 caminhoneiros, sendo 100% (n=84) do gênero masculino. A idade foi de 23 á 49 anos. O fato de haver uma significância na resposta “não sei” em alguns quesitos, chamou atenção, apesar do público avaliado possuir 46% de indivíduos com Ensino Médio completo, demonstrou insuficiente conhecimento sobre o que seja fibras. Conclusão: o estudo evidencia um grande número de caminhoneiros acima do peso e com risco elevado para o desenvolvimento de doenças cardiovasculares, dislipidemias e diabetes, apontando como fatores impactantes a ergonomia, sedentarismo e hábitos alimentares irregulares e não saudáveis, fortemente associados ao estilo de vida característico da profissão.
Palavras-chave: Avaliação Nutricional; Avaliação da Pesquisa em Saúde; Nutrição dos Grupos Vulneráveis; Caminhoneiros; Equivalente Metabólico.
Indicadores de Desempenho da Atenção Primária à Saúde em um município em amplo crescimento populacional
Authors: Campos Bruna Albuquerque , Tavares Marilei de Melo
Published: November 2024

O presente estudo tem por objeto de estudo os indicadores de desempenho obtidos por unidades de saúde da família do município de Maricá. O estudo tem por objetivo elaborar um produto educativo para formação em saúde das equipes multiprofissional de Estratégia de saúde da família do Município de Maricá a fim de fomentar o trabalho desses atores para melhora e/ou alcance dos indicadores do Previne Brasil. Este estudo de caráter descritivo analítico com abordagem qualitativa, com análise documental através de um banco de dados secundários com informações de três meses: março, abril e maio de 2024, de Unidades de Saúde da Família do município de Maricá, RJ, Brasil. Com informações extraídas do banco dos sete indicadores de desempenho nos meses avaliados. Foram respeitados os aspectos éticos da Pesquisa, com aprovação do CEP. Os resultados esperados visa contribuir para o aprimoramento profissional nos serviços de saúde, a partir de material educativo, favorecendo a formação em saúde do profissional que atua na Estratégia Saúde da Família.
Palavras-Chave: Atenção Primária à Saúde; Estratégia Saúde da Família; Indicadores de Saúde; Financiamento da Saúde.
Diagnostic Potential of NEAT1, hsa-let-7a-5p, and miR-506-3p in Early-stage Parkinson's Disease
Authors: Samareh Ali , Nematollahi Mohammad Hadi , Pourghadamyari Hossein , Meimand Hossein Ali Ebrahimi , Shabani Mohammad , Asadikaram Gholamreza
Published: November 2024

Background:

Parkinson's disease (PD) is a multifaceted disease that is influenced
by both genetic and environmental parameters. Non-coding RNAs have been
shown to be ideal biomarkers for several diseases, including PD. This study was conducted
to evaluate the expression levels of NEAT1, hsa-let-7a-5p, and miR-506-3p in individuals
with PD to assess their efficacy for early-stage PD diagnosis.

Methods:

Twenty-four patients with PD and 29 healthy individuals participated in this
study. The IntaRNA tool was used to predict potential base pairings between NEAT1
and let-7a-5p, and NEAT1 and miR-506-3p. RT-qPCR was employed to measure the relative
expression of tyrosine hydroxylase (TH), as well as nuclear enriched abundant transcript
1 (NEAT1), hsa-let-7a-5p, and miR-506-3p levels in both groups. The area under
the receiver operating characteristic curve (AUC) was calculated to evaluate the diagnostic
value.

Results:

The PD group exhibited significantly elevated NEAT1 expression levels compared
to the healthy control group. While the PD group exhibited an insignificant decreased
TH expression level relative to the healthy group. Furthermore, the levels of
hsa-let-7a-5p and miR-506-3p expression were seen to be decreased in patients with PD
in comparison to the control group. Integration of NEAT1, hsa-let-7a-5p, and
miR-506-3p levels significantly enhanced diagnostic capabilities and increased the AUC
to 0.9501 (95% confidence interval: 0.8978-1.000, p <]7 .0001).

Conclusions:

The elevated NEAT1 expression and the decreased expression of hsalet-
7a-5p and miR-506-3p in PD patients indicate that these factors might contribute to
the disease's pathogenesis. Combining the ROC curves of NEAT1 and hsa-let-7a-5p
with miR-506-3p showed improved sensitivity and specificity, facilitating more accurate
PD diagnosis. More importantly, they may contribute as promising non-invasive biomarkers
for PD diagnosis.
Considerations and Challenges to Develop Drug-drug Coamorphous System: A Recent Update
Authors: Tiwari Madhura , Singh Kavita , Chatterjee Bappaditya
Published: November 2024

Poor water solubility of several drugs, especially BCS class II and IV drugs, restricts
their dissolution and negatively affects oral absorption. Amorphization of drugs is a year-old
approach to enhance solubility and dissolution of poorly water-soluble drugs. Polymeric amorphous
systems have been proven effective but have disadvantages, such as low drug loading,
high carrier content, etc. In a coamorphous system, a small molecule can be used as a coformer
that keeps the amorphous form of a drug stable. In a drug-drug coamorphous system (CAS), one
therapeutically active moiety can act as a coformer for the other drug. Although effective, the
rationale of selecting the drugs and optimising the ratio without compromising therapeutic effect
and safety is challenging. The preparation method is also a challenge because the stress during
the processing method may result in the loss of crystallinity. Hence, the processing stability of
the amorphous drug is a significant concern. A stable CAS is formed when two drugs generate
some molecular-level interaction. In silico prediction of miscibility, molecular dynamic simulation,
functional group analysis by Fourier Transform infrared spectroscopy, Raman spectroscopy,
NMR, etc. contribute to the analysis of molecular-level interaction. Additionally, the article
discusses the preparation method and the fact that the excipient must be selected carefully to
form an effective CAS.
Alzheimer's Disease May Benefit from Olive Oil Polyphenols: A Systematic Review on Preclinical Evidence Supporting the Effect of Oleocanthal on Amyloid-β Load
Authors: Zupo Roberta , Castellana Fabio , Panza Francesco , Solfrizzi Vincenzo , Lozupone Madia , Tardugno Roberta , Cicero Nicola , Corbo Filomena , Crupi Pasquale , Sardone Rodolfo , Clodoveo Maria Lisa
Published: November 2024

Background:

Mediterranean diet may enhance cognitive function and delay the progression
of Alzheimer's disease (AD). We conducted a systematic review to investigate the effect of
oleocanthal (OC) from extra-virgin olive oil (EVOO) on amyloid-β (Aβ) burden in preclinical models
of AD, considering the anti-inflammatory and neuroprotective effects of EVOO biophenols,
which are key components of the Mediterranean dietary model.

Methods:

The literature was searched through six electronic databases until February 2023. Screening
of 52 retrieved articles for inclusion criteria resulted in 7 preclinical reports evaluating the effect
of an OC-supplemented diet on AD trajectories by means of Aβ load or clearance in affected models.
Reports were appraised for risk of bias using the SYRCLE's RoB tool. A protocol was registered on
PROSPERO.

Results:

Case control prevailed over the case-crossover design, and the geographical distribution was
uniformly American. The study population mostly included 5xFAD, otherwise TgSwDI or wild-type
C57BL/6 mouse models. We found a role of OC in reducing Aβ load in the hippocampal parenchyma
and microvessels compared with controls. An increased cerebral clearance of Aβ through the bloodbrain
barrier and a substantial improvement in metabolic and behavioral parameters were also reported
in preclinical models under an OC-enriched diet. The risk of bias was shown to be moderate overall.

Conclusion:

Preclinical data are promising about the effects of OC from the Mediterranean diet's
EVOO in relieving the burden of Aβ in AD; however, further evidence is needed to corroborate the
efficacy of this biophenol and strengthen the speculated causal pathway.
Targeting Wnt Pathways with Small Molecules as New Approach in Cardiovascular Disease
Authors: Mousavi Seyed Mehdi , Jalali-Zefrei Fatemeh , Shourmij Mohammad , Tabaghi Shiva , Davari Amirhesam , Khalili Saeed Bahador , Farzipour Soghra , Salari Arsalan
Published: November 2024

The increasing incidences of morbidity and mortality associated with cardiovascular
diseases represent significant difficulties for clinical treatment and have a major impact on patient
health. Wnt signaling pathways are highly conserved and are well known for their regulatory
roles in embryonic development, tissue regeneration, and adult tissue homeostasis. Wnt signaling
is classified into two distinct pathways: canonical Wnt/β-catenin signaling and noncanonical
pathways, including planar cell polarity and Wnt/Ca2+ pathways. A growing body of
experimental evidence suggests the involvement of both canonical and non-canonical Wnt signaling
pathways in the development of cardiovascular diseases, including myocardial hypertrophy,
arrhythmias, diabetic cardiomyopathy, arrhythmogenic cardiomyopathy, and myocardial
infarction. Thus, to enhance patient quality of life, diagnosing and treating cardiac illnesses may
require a thorough understanding of the molecular functions played by the Wnt pathway in these
disorders. Many small-molecule inhibitors specifically target various components within the
Wnt signaling pathways, such as Frizzled, Disheveled, Porcupine, and Tankyrase. This study
aims to present an overview of the latest findings regarding the functions of Wnt signaling in
human cardiac disorders and possible inhibitors of Wnt, which could lead to novel approaches
for treating cardiac ailments.
Imidazole-Based Metal Complex Derivatives: A Comprehensive Overview of Synthesis and Biological Applications
Authors: Hiremath Arpita F. , M. R. Pradeep Kumar , Rajagopal Kalirajan , Barua Rashu , Obaidur Rab Safia , Alshehri Mohammed Ali , Bin Emran Talha
Published: November 2024

The imidazole scaffold is a cornerstone in medicinal chemistry, widely recognized for its
extensive range of biological activities and ability to form stable metal complexes. This review
article provides a detailed overview of recent advancements in synthesizing, characterization, and
biological evaluation of metal-complexed imidazole derivatives. We explored various synthetic
strategies to create diverse metal-based imidazole complexes, emphasizing innovations that enhance
efficiency and yield. Furthermore, we delve into the biological profiling of imidazole derivatives,
summarizing key findings from studies investigating their antimicrobial, antifungal, anticancer,
and other therapeutic properties. Special attention is given to metal coordination's role in
modulating these compounds' biological activity. The review discusses the synthesis of imidazolemetal
complexes, illustrating how metal ions such as copper, zinc, and iron enhance the pharmacological
profiles of imidazole derivatives. Thus, the data from numerous studies was collated and
analyzed to comprehensively understand the current landscape and future prospects in imidazole
chemistry associated with metals. It is a valuable resource for researchers, guiding future investigations
and fostering the development of novel metal-based imidazole therapeutics.
Role of Dual GIP and GLP-1 Receptor Agonist, Tirzepatide in the Management of Weight Loss; A Systematic Review
Authors: Rangraze Imran Rashid , Khan Shehla , Wali Adil Farooq , Menezes Godfred , Goud Manjunatha , Jabran Muhammad
Published: November 2024

Aim:

The eventuality of tirzepatide, a binary GIP and GLP- 1 receptor agonist, as a
treatment for rotundity and metabolic diseases is addressed in this comprehensive review.

Background:

A definition of tirzepatide is that it is an implicit intervention for rotundity, given
its effectualness per the cure-dependent effect. Beyond the beneficial effects on body weight loss,
tirzepatide also brings about an improvement in lipid biographies and insulin perceptivity, in harmony
with binary receptor activation.

Methodology:

Assaying data from seven phases 3 trials, it's constantly shown that tirizepatide reduces
body weight in a significant and clinically meaningful way for a variety of party biographies
and lengths of time.

Results:

The drug's effect was supported by its favorable safety profile, which shows low prevalence
rates of common adverse goods. Its efficacy in the management of type 2 diabetes is supported
by relative evaluations, underscoring the inevitability of its breakthrough as a therapeutic volition.
Treatment individualization is key, as evidenced by the tailor-made response proposed by
group analysis based on birth BMI. The efficacy, safety, and demand for personalized treatment
plans of tirzepatide are each supported in recommendations for clinical practice.

Conclusion:

Tirzepatide's eventuality as a long-term strategy for habitual rotundity is corroborated
by long-term follow-up studies that show sustained weight loss. Indeed with these encouraging
results, further study and clinical experience are demanded to completely comprehend the safety,
optimal integration, and long-term effectiveness of tirzepatide in a multiplicity of patient populations.
Non-alcoholic Wernicke Encephalopathy in a Young Patient with Adenocarcinoma of the Colon: A Case Report and Review of the Literature
Authors: Ziogou Afroditi , Lymperis Andreas , Skouteris Nikolaos , Charalampakis Nikolaos
Published: November 2024

Introduction:

Wernicke Encephalopathy (W.E.) is an acute neurological disorder induced
by thiamine deficiency. Alcohol abuse is considered to be the leading cause of the disease;
however, numerous other conditions, such as malnutrition or cancer, have been identified as potential
risk factors.

Case Presentation:

Clinical manifestations include a typical triad of mental status alteration, nystagmus,
and ataxia and are attributed to damage in brain regions of high thiamine demand. The diagnosis
is mainly clinical and further supported by the immediate response of neurological signs
to parenteral thiamine administration. Among paraclinical examinations, brain MRI is considered
substantial for diagnosis and is supported by the determination of thiamine blood levels.

Conclusion:

Non-alcoholic W.E. is trickier to diagnose due to its atypical clinical course and risk
factors. We herein describe a case of non-alcoholic W.E. in a woman with colon cancer who gradually
developed the classic symptoms of thiamine deficiency.
Parkinson’s Disease: A Progressive Neurodegenerative Disorder and Structure-Activity Relationship of MAO Inhibitor Scaffolds as an Important Therapeutic Regimen
Authors: Salauddin  , Zaidi Syed Amir Azam , Ubaid Mohammed , Shamim Saniya , Naim Mohd. Javed , Khanna Suruchi , Alam Ozair
Published: November 2024

Parkinson’s disease is considered an advancing neurodegenerative disorder with unknown
causes, and its association with some risk factors, including aging, family history, and exposure
to chemicals, makes it the second most common occurring neurodegenerative disorder
throughout the world with increasing prevalence. Parkinson’s disease is associated with slow
movement, rigidity, tremors, imbalance, depression, anxiety, cognitive impairment, orthostasis, hyperhidrosis,
sleep disorders, pain, and sensory disturbances. In recent decades, there has been a rise
in research on the development of effective and potential therapies for the treatment of Parkinson’s
disease. An important target for neuroprotection is Monoamine Oxidases (MAO), which hydrolyze
neurotransmitters like dopamine and produce very reactive free radicals as a by-product. Aging and
neurodegenerative illnesses cause overexpression in the brain, which exacerbates neuronal loss. The
treatment of Parkinson's disease with MAO inhibitors has shown promising outcomes. Herein, we
reported characteristic features of Parkinson’s disease, various treatment strategies, and the SAR of
potential drugs that can be explored further as lead for the development of newer molecules with
improved pharmacological profiles.
Advanced Technologies in Rectal Drug Delivery Systems: A Comprehensive Review of Recent Innovations and Future Prospects
Authors: Liew Kai Bin , Yahya Farah Shazwani , Azli Nur Dini Wardina , Segaran Abirami Sathia , Wong Yit Yien , Kee Phei Er
Published: November 2024

Rectal Drug Delivery System (RDDS) emerges as an alternative administration route
due to the rectum's small surface area and limited enzyme activity, which contribute to efficient
drug absorption. RDDS offers various advantages, such as reduced first-pass metabolism, rapid absorption
of low molecular weight drugs, and the ability to accommodate large retention volumes
and facilitate absorption via the lymphatic system. Moreover, RDDS is preferable for drugs with
low stability, solubility, and permeability via oral administration, as well as effectively addressing
concerns related to gastric irritation or degradation. This review delves into the factors influencing
drug absorption in RDDS, including drug properties, formulation types, and physiological and
pathology-associated considerations. It further explores conventional RDDS, including enemas,
suppositories, tablets, gels, sprays, ointments, and creams, as well as novel approaches involving
nanoparticles, liposomes, microspheres, and solid lipid nanoparticles (SLNs) in rectal dosage
forms. Furthermore, the challenges and prospects of RDDS in treating rectal diseases are discussed.
This review provides valuable insights into the potential of RDDS, highlighting the importance
of continuous research and development in enhancing patient outcomes and advancing
healthcare practices.
A Comprehensive Examination of Common Poisoning and Snakebite Envenoming: Clinical Characteristics, Therapeutic Approaches, and Implications
Authors: Fadadu Bhoomi , Arvadiya Raj , Dudhat Kiran
Published: November 2024

Human toxin poisoning from a variety of sources, including plants, animals, and chemical compounds, is a major concern for global health. Snake envenomation is a common and possibly fatal kind of poisoning among these. In addition to covering other well-known toxin exposures, this page offers a thorough study of human poisoning episodes with a special focus on snake envenomation. The study begins by outlining the geographic distribution of venomous snake species and their effects on various populations. It next discusses the occur-rence of snakebite incidents worldwide. It explores the complex structure of snake venom and clarifies the many impacts of its constituent parts on human physiology.

The article investigates the corresponding clinical signs and medical care strategies by classi-fying venoms into hemotoxic, neurotoxic, and cytotoxic forms. The essay also looks into the socioeconomic effects of snakebite envenomation, highlighting how rural and low-income groups suffer disproportionately in areas with limited access to antivenom and medical care. It also emphasizes the efforts made by local programs and international health organizations to lessen the burden of morbidity and mortality associated with snakebite injuries. The article ex-tends its focus beyond snake envenomation to include additional causes of human poisoning, such as plant toxins, chemical pollutants, and animal venoms. It provides prominent examples of poisoning occurrences produced by various compounds as well as an explanation of the me-chanics of toxicity. The difficulties in diagnosing and treating such situations are also discussed, emphasizing the value of prompt and precise medical interventions.
Revealing the Unseen: Post COVID-19 Biomarkers, Severity, and Outcome Mysteries
Authors: Rosyid Alfian Nur , Puspitasari Arina Dery , Sensusiati Anggraini Dwi , Nugraha Jusak , Amin Muhammad
Published: November 2024

Background:

Although the COVID-19 pandemic has passed, some patients still experience
post-COVID-19 symptoms. It has been reported that COVID-19 symptoms can persist for more
than three months after recovery.

Objective:

This study aims to analyze biomarkers, severity, and outcome factors associated with
post-COVID-19 symptoms.

Methods:

This prospective cohort study involves hospitalised COVID-19 patients who were followed
for up to 3 months after discharge. Clinical examinations and laboratory tests for MMP-9,
TIMP-1, and IL-6 were conducted during hospitalisation and after three months.

Results:

We enrolled 76 COVID-19 patients, with a mortality rate of 30.26%. Among them, 55 individuals
(30.91%) had no residual symptoms, 54.5% had acute COVID-19, 9.09% had ongoing
COVID-19, and 5.45% had long-term COVID-19. Symptomatic post-COVID-19 had oxygen demand
and respiratory rates higher than no-symptoms groups. Early IL-6, IL-10, MMP-9, and TIMP-
1 were lower in symptomatic post-COVID-19 compared to dead and asymptomatic post-COVID-19
groups. IL-6 and MMP-9 decrease, and TIMP-1 increases after cure. IL-6 significantly still increases
in post-COVID-19 symptoms compared to no-symptoms (p=0.01). Patients more than 50 years old
and critically ventilated patients are prone to have symptoms post-COVID-19.

Conclusions:

More than half of patients suffer from post-COVID-19 symptoms with various related
factors. Even though IL-6 decreases after recovery, IL-6 levels are still higher in symptomatic post-
COVID-19 patients.
Ruimte voor regulering van politieke microtargeting
Authors: Maasbommel Sam
Published: November 2024

De verkiezingsstrijd digitaliseert. Politieke partijen maken dankbaar gebruik van de technologische mogelijkheden die de eenentwintigste eeuw te bieden heeft. Microtargeting, in het bijzonder via de sociale media, stelt hen in staat om op basis van data-analyse individuele burgers op maat gemaakte campagne-berichten te sturen: ouderen over de AOW, studenten over de basisbeurs. Zelfs de toonzetting kan worden afgestemd op de karaktertrekken van de ontvanger opdat de boodschap zo goed mogelijk overkomt. Sinds het Cambridge Analytica-schandaal (2016) bestaan zorgen met betrekking tot transparantie, publieke deliberatie en kiezersautonomie. Hierdoor is ook in Nederland de vraag gerezen of het fenomeen aan banden zou moeten worden gelegd, en zo ja, welke ruimte daarvoor bestaat. Dat reguleringsvraagstuk staat in dit onderzoek centraal. Het beoogt enerzijds bij te dragen aan de kennis over microtargeting en in het bijzonder zijn juridische context, en anderzijds handvatten te bieden voor het opstellen van houdbare, doelmatige en binnen de nationale context passende regels. Daartoe wordt het onderzoeksobject vanuit een drietal invalshoeken benaderd. Na een probleemanalyse wordt microtargeting als campagneinstrument in de Nederlandse (‘non-interventionistische’) partij reguleringstraditie geplaatst om hieraan beginselen en uitgangspunten te ontlenen. Vervolgens worden vanuit een grondrechtelijk perspectief de grenzen aangegeven binnen welke de wetgever hierbij heeft te opereren. Tot slot wordt ter inspiratie een blik geworpen over de Amerikaanse, Franse en Duitse grens alwaar maatregelen worden of zijn getroffen in de sfeer van digitale campagne- en debatvoering.
PENGARUH LAMA FERMENTASI TERHADAP KEBERADAAN MIKROORGANISME LOKAL (MOL) PADA EKOENZIM BERBASIS LIMBAH BUAH DAN SAYUR
Authors: Fitria Arrum , Suhartini Suhartini
Published: November 2024

Penelitian ini bertujuan untuk mengetahui pengaruh lama fermentasi terhadap keberadaan mikroorganisme lokal (MOL) pada ekoenzim dan mengidentifikasi MOL yang berperan dalam proses fermentasi ekoenzim berbasis limbah buah dan sayur ditinjau dari lama fermentasinya. Jenis penelitian ini adalah kuantitatif dengan pendekatan deskriptif-eksploratif. Isolasi MOL dilakukan dengan perlakuan lama fementasi (45 hari dan 90 hari). Identifikasi berdasarkan morfologi koloni, morfologi sel, dan sifat fisiologis. Isolat mikroorganisme yang diperoleh diidentifikasi dengan profile matching. Pengaruh lama fermentasi terhadap keberadaan MOL dianalisis menggunakan aplikasi statistik dengan menerapkan uji One-Way Anova dan uji lanjut Tukey HSD dengan taraf signifikansi 5%. Karater fenotipik pada bakteri dianalisis menggunakan program MVSP (Multivariate Statistical Package. Hasil penelitian ini adalah lama fermentasi berpengaruh terhadap keberadaan MOL. Semakin lama waktu fermentasi pada fase awal stasioner menuju fase kematian jumlah mikroorganisme lokal berkurang. Hasil dari identifikasi mikroorganisme lokal adalah ditemukannya 3 genus bakteri yaitu Megasphaera, Lactobacillus, dan Cellulomonas. 3 genus kapang yang ditemukan adalah Aspergillus, Penicillium, dan Mycelia sterilia, serta 1 genus yeast berupa Saccharomyces. Kata kunci: mikroorganisme lokal; ekoenzim; lama fermentasi; identifikasi.
PENGARUH KOMBINASI EKSTRAK KECIPIR (Psophocarpus tetragonolobus L.) DAN KACANG POLONG (Pisum sativum) TERHADAP JUMLAH FOLIKEL OVARIUM DAN STRUKTUR HISTOLOGI USUS HALUS TIKUS PUTIH (Rattus norvegicus)
Authors: Florean Yuan Dewi , Harjana Tri
Published: November 2024

Abstrak. Penelitian ini bertujuan untuk mengetahui pengaruh kombinasi ekstrak kecipir (Psophocarpus tetragonolobus L.) dan kacang polong (Pisum sativum) terhadap jumlah folikel ovarium dan struktur histologi usus halus tikus putih (Rattus norvegicus). Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan satu perlakuan yaitu P0 sebagai kontrol, perlakuan P1 (25mg/ kgBB ekstrak biji kecipir + 75mg/ kgBB tikus ekstrak biji kacang polong), P2 (50mg/ kgBB ekstrak biji kecipir + 50mg/ kgBB biji kacang polong ), dan P3 (75mg/ kgBB ekstrak biji kecipir + 25mg/ kgBB ekstrak biji kacang polong). Data yang diamati adalah jumlah folikel ovarium serta kerusakan usus halus. Data masing-masing ovarium dianalisis menggunakan One Way Anova. Apabila terdapat pengaruh nyata, maka dilakukan uji lanjutan dengan uji Duncan’s Multiple Range Test (DMRT). Untuk organ usus halus dianalisis menggunakan analisis deskriptif. Hasil penelitian menunjukkan bahwa pemberian kombinasi ekstrak kecipir dan kacang polong memberikan pengaruh nyata (P0,05) terhadap jumlah folikel ovarium tikus putih. Sedangkan struktur histologi usus halus tikus putih normal.  Kata kunci: ekstrak kecipir dan kacang polong, jumlah folikel ovarium, struktur histologi usus halus, tikus putih.
POTENSI PEMANFAATAN ECO-ENZYM BERBASIS BUAH SEBAGAI PUPUK PADA PERTUMBUHAN SAWI HIJAU (Brassica juncea L.)
Authors: Nur Laila Nuri Amalia , - Suhartini
Published: November 2024

Abstrak. Eco-enzym merupakan larutan atau cairan hasil fermentasi dari limbah organik. Penelitian ini bertujuan untuk mengetahui (1) potensi eco-enzym sebagai pupuk organik cair berdasarkan uji fisik, kimia dan uji kandungan unsur hara (2) pengaruh variasi konsentrasi eco-enzym berbasis buah terhadap pertumbuhan tanaman sawi hijau (Brassica juncea L.). Penelitian ini menggunakan 1 perlakuan. Data pada penelitian ini dianalisis menggunakan uji one way anova. Hasil penelitian menunjukkan bahwa: (1) Hasil yang didapatkan belum memenuhi standar mutu pupuk organik cair Keputusan Menteri No. 261/KPTS/SR.310/M/4/2019, karena ecoenzym mengandung C-organik (1,52%); pH (3,2); dan NPK (0,24%) (2) Variasi konsentrasi 2% merupakan konsentrasi terbaik untuk pertumbuhan tinggi tanaman dan jumlah daun tanaman sawi sehingga eco-enzym konsentrasi 2% berpotensi untuk dijadikan sebagai pupuk organik cair.  Kata kunci : Eco-enzym, tanaman sawi, variasi konsentrasi
Desain Primer Untuk Isolasi Gen L-LDH Berdasarkan Genom Streptococcus pluranimalium dan Aplikasinya
Authors: Rifqi Daffa Muhammad , Mercuriani Ixora Sartika
Published: November 2024

Asam laktat diketahui merupakan molekul dengan manfaat positif untuk manusia. Molekul tersebut dapat diproduksi oleh bakteri asam laktat. Produksi asam laktat seringkali terganggu karena beberapa spesies bakteri perlu penyesuaian khusus pada substrat, sehingga salah satu solusinya adalah kloning gen atau over-expression enzim L-LDH pada bakteri kompeten. Salah satu langkah prosedur tersebut adalah isolasi gen. Desain primer dilakukan menggunakan aplikasi Benchling pada subjek genom Streptococcus pluranimalium TH11417 dan seluruh primer diujikan secara in-silico menggunakan aplikasi UGENE dan in-vitro menggunakan metode Polymerase Chain Reaction (PCR). Empat pasang primer dihasilkan dengan rincian LSPai 1178, LSPbi 993, LSPad 765, dan LSPbd 846. Primer berhasil menempel dan menghasilkan amplikon yang sesuai pada uji in-silico menggunakan templat genom S. pluranimalium TH11417, namun hanya LSPai 1178 dan LSPad 765 yang dapat menempel pada templat genom S. pluranimalium 14A0014. Primer tidak dapat menempel pada uji in-vitro dikarenakan kontaminasi isolat bakteri templat DNA. Kontaminasi dikonfirmasi melalui analisis sekuen 16s rRNA dan didapatkan bahwa amplikon 16s rRNA isolat bakteri uji sesuai dengan sekuen 16s rRNA Bacillus cereus. Sekuensing basa amplikon uji in-vitro primer LSPai 1178 menunjukkan bahwa amplikon bukan merupakan bagian dari sekuen target.
PENGARUH KOMBINASI KONSENTRASI ZAT PENGATUR TUMBUH NAA DAN 2-IP TERHADAP PERTUMBUHAN ANGGREK Dendrobium sp. SECARA IN VITRO
Authors: Suryani Suryani , Ratnawati Ratnawati
Published: November 2024

Abstrak. Tujuan penelitian ini adalah untuk mengetahui pengaruh kombinasi konsentrasi NAA dan 2-iP dan interaksi kedua faktor terhadap pertumbuhan tunas aksiler anggrek Dendrobium sp., mengetahui kombinasi konsentrasi yang optimum dan posisi nodus terbaik, Rancangan penelitian yang digunakan adalah Rancangan Acak Lengkap Faktorial, terdiri dari dua faktor: kombinasi konsentrasi zpt (NAA (0; 0,05; 0,1; 0,15; 0,2), 2-iP (2; 1,5; 1; 0,5; 0) dan posisi nodus (atas, bawah, tengah) sebanyak 6 ulangan. Eksplan menggunakan anggrek silangan Dendrobium Apel Ireng (D.S.Santoso 2019) x Dendrobium Vian (D.S.Santoso 2018) dari Dede Orchid Malang dan memiliki 4 nodus. Medium dasar mengunakan New Phalaenopsis (NP)+Air Kelapa. Data yang diperoleh dianalisis menggunakan ANOVA. Jika terjadi beda nyata, analisis dilanjutkan dengan uji DMRT dengan taraf nyata 5%. Hasil penelitian menunjukkan bahwa penambahan 0,1 ppm NAA + 1 ppm 2-iP optimum pada pertumbuhan tunas aksiler anggrek Dendrobium Apel Ireng x Dendrobium Vian. Posisi nodus terbaik adalah posisi nodus bagian tengah. Tidak terdapat pengaruh penambahan variasi kombinasi konsentrasi zpt  (NAA+2-iP) dalam menginduksi tunas aksiler pada semua parameter serta tidak terdapat interaksi variasi kombinasi konsentrasi zpt (NAA+2-iP) dan posisi nodus terhadap induksi tunas aksiler pada semua parameter. Kata kunci : NAA, 2-iP, Posisi Nodus, Dendrobium sp., Kultur Jaringan, Tunas Aksiler
Geographical analysis of groundwater type distribution in Khabat district, using geographical information system (GIS)
Authors: Azeez Jwanro Azad , Abdullah Soran Abdulfattah , Bakr Bnar Abdulakhaliq
Published: November 2024

Khabat district is our study are , which is located in the west of Erbil province and covers an area of 660.2 km2.Most of the population in this district depends on groundwater for most of their daily needs; therefore, our main goal is to determine the quality of groundwater in this area, especially in terms of chemical and physical analysis, determining the appropriate groundwater level, and identifying good and bad areas for drinking water usage. In this study, we have analyzed the quality of the groundwater for more than 48 water wells in the area through the use of the GIS program and (Interpolating IDW) , (Overlay), and(AHP)model. The value of each chemical and physical element of the water wells in the district has been studied by comparing the analyzed water in different wells using the drinking water standards.
Consequently, it has been found that the groundwater in most study areas of Khabat district is suitable for drinking. Finally ,we have been able to determine a typical map of groundwater analysis of the area. It is noteworthy that most of the area of the study district produces great drinking water, which accounts for 50.35% of the area .However, the least productive area produces bad drinking water, which accounts for only 4.2% of this type of groundwater. The rest is considered to be medium in terms of quality, which reaches (45.45%).
He has a lot of things to do with him, and he has two days of work for him, and he has two days to go. There is a lot of information about this country, and there is nothing like this in other countries.
Efecto del proceso de tostado en el contenido de polifenoles totales, actividad antioxidante y evaluación sensorial del café producido en Perú
Authors: Huaccha-Herrera Celinda , Ordoñez-Gómez Elizabeth , Villanueva-Tiburcio Juan Edson
Published: November 2024

El café es un alimento mundial que se comercializa con base en la calidad del grano, por sus características físicas y organolépticas. En Perú, en la región Huánuco, provincia de Leoncio Prado, se producen cafés de las variedades Typica y Bourbon, sin embargo, existe poca información sobre el efecto de los grados de tostado en la calidad de la taza y las propiedades antioxidantes. Los objetivos fueron evaluar el efecto de diferentes grados en el proceso de tostado de ambos cafés; evaluar el contenido de polifenoles totales, capacidad antioxidante (DPPH y ABTS+) y calidad del café en taza, mediante el método reportado por el Coffee Quality Institute. Las muestras de café verde oro también fueron sometidas a procesos de tostado claro, medio y oscuro, con un diseño estadístico factorial de 2ᶺ3, se realizó un análisis descriptivo cuantitativo (ADC) y un análisis de componentes principales (ACP). Los resultados mostraron que el tostado claro en cafés Typica y Bourbon ofrecieron un mayor contenido de polifenoles totales (4,13 ± 0,03 g AGE/100 g y 4,13 ± 0,01 g AGE/100 g) y actividad antioxidante frente al DPPH (IC50 155,66 ± 3,4 μg/ml y 170,41 ± 1,06 μg/ml, respectivamente) y ABTS+ (53,19 ± 0,16 μg/ml y 43,17 ± 0,57 μg/ml); la variedad Typica con tostado claro y la variedad Bourbon con tostados claro y medio ofrecieron las mejores características sensoriales. Los diferentes grados de tostado en el café provocaron cambios sensoriales y variaciones en el contenido de los principios activos, mientras que el grado de tostado claro ofreció una mayor cantidad de principios activos en el café que podrían ser aprovechados por los consumidores.
New Records of Insect Predators of Invasive Fluted Scales (Hemiptera: Monophlebidae: Iceryini) in Ecuador
Authors: Arias de López Myriam , Molina Moreira Natalia , Forero Dimitri , González F. Guillermo , Kondo Takumasa
Published: November 2024

Population outbreaks of invasive fluted scales in urban areas of Ecuador have become frequent in recent years. Despite the negative impact that these scale insects cause on the native flora, little is known about the natural enemies that control their populations in Ecuador. During collections and observations carried out between July and October 2021 in the province of Guayas, in western Ecuador, high infestations caused by the invasive pests Crypticerya genistae (Hempel, 1912), Crypticerya multicicatrices Kondo & Unruh, 2009, and Icerya purchasi Maskell, 1879 (Hemiptera: Coccomorpha: Monophlebidae: Iceryini) were found. Hence, this study aimed to determine the natural enemies of these fluted scales using taxonomic keys based on their morphological characteristics. As a result, five species of predators were identified, i.e., Novius punicus (Gordon, 1972), Novius cardinalis (Mulsant, 1850) (Coleoptera: Coccinellidae), Syneura cocciphila (Coquillet, 1895) (Diptera: Phoridae), Ceraeochrysa sp. (Neuroptera: Chrysopidae), and Cardiastethus sp. (Hemiptera: Anthocoridae); the latter is reported preying on C. multicicatrices for the first time. Knowledge of natural enemies is crucial for developing more effective, eco-friendly pest management strategies that could help mitigate the adverse effects of these invasive scale insects.
Efficacy of a Wearable Activity Tracker With Step-by-Step Goal-Setting on Older Adults’ Physical Activity and Sarcopenia Indicators: Clustered Trial
Authors: Ho Mu-Hsing , Peng Chi-Yuan , Liao Yung , Yen Hsin-Yen
Published: November 2024

Background

Smart wearable technology has potential benefits for promoting physical activity and preventing sarcopenia.

Objective

The purpose of this study was to explore the efficacy of a wearable activity tracker with 2-stage goal-setting for daily steps on older adults’ physical activity and sarcopenia indicators.

Methods

The study used a clustered trial design and was conducted in March to June 2022. Participants were community-dwelling adults older than 60 years who were recruited from 4 community centers in Taipei City. The intervention was designed with 2-stage goals set to 5000 steps/day in the first 4 weeks and 7500 steps/day in the final 4 weeks while wearing a commercial wearable activity tracker. Data were collected by self-reported questionnaires, a body composition analyzer, a handle grip tester, and 5 sit-to-stand tests.

Results

All 27 participants in the experimental group and 31 participants in the control group completed the 8-week intervention. Total and light-intensity physical activities, skeletal muscle index, and muscle strength increased, while sedentary time, BMI, and the waist circumference of participants decreased in the experimental group, with significant group-by-time interactions compared to the control group.

Conclusions

A wearable activity tracker with gradual goal-setting is an efficient approach to improve older adults’ physical activity and sarcopenia indicators. Smart wearable products with behavioral change techniques are recommended to prevent sarcopenia in older adult populations.
The Efficacy of Benzodiazepines Combined with Cognitive Behavioural Therapy for Insomnia in the Adjunctive Treatment of Insomnia Disorder with Anxiety and Depression (Preprint)
Authors: Chen Jinhong
Published: November 2024

BACKGROUND

Insomnia stands as a prevalent clinical sleep disorder characterized by a spectrum of symptoms that encompass challenges in initiating sleep, shortened periods of rest, premature awakening coupled with compromised daytime performance, heightened fatigue, diminished focus, and impaired memory retention, the multifaceted nature of this condition underscores its impact on both physical and cognitive well-being, often leading to a cascade of adverse effects on overall health and quality of life

OBJECTIVE

To investigate the clinical efficacy of benzodiazepine (BZDs) combined with cognitive-behavioral therapy (CBT-I) for the adjuvant treatment of sleep quality and mood in patients with insomnia disorder accompanied by anxiety and depression symptoms.

METHODS

Patients who visited the Sleep and Neurology departments of the Second People's Hospital of Hunan Province from June 2021 to December 2022 were selected as the study subjects. They were divided into two groups according to inclusion and exclusion criteria: 26 cases in the insomnia group and 29 cases in the insomnia group with anxiety and depression symptoms. Both groups received BZDs combined with CBT-I adjuvant therapy. Compare the Pittsburgh Sleep Quality Index (PSQI) scores, Hamilton Anxiety Scale (HAMA) scores, Hamilton Depression Scale (HAMD) scores, and polysomnography (PSG) parameters between two groups before and after treatment.

RESULTS

After treatment, the PSQI scores of the two groups significantly decreased and SE significantly increased (P<0.001), while the total sleep time was significantly prolonged (P<0.05); after treatment, the second phase sleep time of the group with insomnia and anxiety and depression symptoms was significantly prolonged (P<0.05), N1 (%) was significantly reduced (P<0.05), and the second phase sleep time, second phase sleep latency, and REM sleep latency of the insomnia group were significantly prolonged (P<0.05). After treatment, the insomnia group with anxiety and depression had a significantly shorter latent period of phase 2 sleep and a significantly increased PSQI score compared to the insomnia group (P<0.05), while there was no statistically significant difference in HAMD score, HAMA score, and other PSG parameters (P>0.05).

CONCLUSIONS

The combination of BZDs and CBT-I adjuvant therapy has a good improvement effect on patients with insomnia anxiety and depression symptoms.

CLINICALTRIAL

None.
Gender Roles and the Impact of Welfare Policies on the Gender Gap in Japan
Authors: Yuezhang Chen
Published: November 2024

This essay investigates how, even though economic progress is being made, welfare policies deepen traditional gender roles in Japan. The paper gives specific examples of such policies to show how such measures either work to promote gender equality or, on the contrary, strengthen stereotypes. Conclusion Overall, most of the policies outlined have good intentions, but they are groomed with little efficacy attributed to cultural norms and inadequate stakeholder implementation participation. This essay encourages future policy recommendations that increase childcare capacity, enforce equal pay, and encourage male involvement in caregiving. Research should address overcoming cultural barriers in attaining a more gender-equitable society in Japan.
A Contrastive Study of Chinese-English Translation of Ancient Poetry from the Perspective of Aesthetics of Reception: A Case Study of the Two Translations of Vain Longing
Authors: Wang Mengyao
Published: November 2024

The Chinese literary classic "Dream of the Red Chamber" features a variety of poems and songs, with "Vain Longing," which serves as its theme song, being particularly popular among readers both domestically and internationally. Among the many translations available, those by Yang Xianyi and Gladys Yang, along with Hawkes' version, are the most prominent and hold significant research value. Acceptance Aesthetics, which emerged from the German critical school in the 20th century, provides a fresh lens through which to view the translation of ancient Chinese poetry. This paper utilizes Aesthetics of reception as its theoretical framework and focuses on the English translations of "Vain Longing" by Yang Xianyi and Gladys Yang as well as Hawkes found in "Dream of the Red Chamber." By examining their translation philosophies and approaches, this study aims to contribute insights for translating ancient poetry within literary contexts while enhancing global appreciation for Chinese poetic beauty and promoting classical Chinese culture.