bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular Docking and QSAR studies for Modeling Antifungal Activity of Triazine Analogues against Therapeutic Target NMT of Candida albicans
Authors: Jain Dabade Sapna , Mandloi Dheeraj , Bajaj Amritlal V , Atre Harsh
Published: June 2022

The s-triazine derivatives have been attracting the attention of researchers due to a broad range of biological applications. Present research deals with combination of GA- MLR based QSAR modeling and molecular docking as relevant to triazine analogues in an attempt to investigate their role as novel NMT inhibitors of Candida albicans. A penta-varient model which assure all validation criteria up to considerable echelon (R2 = 0.792, Q2 = 0.679 and  = 0.603) supplemented by multicollinearity diagnosis by VIF and tolerance data analysis, signaling the robustness of the QSAR model. The descriptors RDF040v, Ds, Mor04m, X4v and MATS2p in the projected QSAR model have quantified the role of atomic properties such as topology; atomic van der Waals volume, mass and polarizability execute vital part to modify the antifungal activity of compounds under investigation. Further, molecular docking simulation study revealed that three compounds in particular showed superior binding affinity with  re-rank score of -142.594, -138.972, -137.540  kcal/mol respectively. Consequently this study may turn out to be helpful towards development and optimization of existing antifungal activity of compounds under investigation.
Antiproliferative effects of the root bark of Gardenia gummifera L. f on HepG2 cell lines
Authors: Dwarai Suma , Sankunni Latha M.
Published: June 2022

Gardenia gummifera L. f is a rarely explored medicinal plant species found in the dry forests of Karnataka, Tamil Nadu, Andhra Pradesh, and Kerala. The present work evaluates the anti-proliferative effect of the root bark of G. gummifera on HepG2 cell lines. With standard protocols, qualitative and quantitative phytochemical analysis of petroleum ether, chloroform, acetone, ethanol, and aqueous extracts were carried out. The acetone, ethanol, and aqueous extracts from the root bark of G. gummifera were subjected to antioxidant assays. The anti-proliferative assays such as methyl tetrazolium (MTT) assay, Neutral red assay, and lactate dehydrogenase (LDH) leakage were performed on HepG2 cell lines. The phytochemical examination indicated the presence of primary and secondary metabolites, especially polyphenolic compounds. Among the different extracts, acetone, ethanol, and aqueous extracts exhibited maximum availability of flavonoids and tannins. Also, ethanol extract exhibited the highest free radical scavenging potential with the lowest IC50. Between the different extracts, the highest cytotoxic activity was observed in the ethanol extract of G. gummifera. Hence, this work highlights the significance of ethanol extract of G. gummifera L. f as a potent anti-cancer agent for clinical use in the battle against liver cancer.
FORMULATION AND OPTIMIZATION OF GUGGUL LIPID PHYTOSOMAL GEL OF THYMOQUINONE USING 22 FACTORIAL DESIGN
Authors: MUBEEN HAJERA , Mannan Abdul
Published: June 2022

Thymoquinone is a bioactive principal constituent of Nigella Sativa. Thymoquinone is hydrophobic, having low water solubility and less permeability. The study aimed to formulate and optimize Thymoquinone loaded phytosomes using guggul lipid by thin-film method to enhance permeation and stability. 2 factor 2 level design (22) using SigmaTech software was employed contour plots were used to predict the responses. The two independent variables used were: the amount of guggul lipid (X1), amount of cholesterol (X2); and the responses included entrapment efficiency (Y1), in-vitro drug release (Y2), and particle size (Y3). The optimized formulation of Thymoquinone phytosomes was incorporated into Carbopol 934 gel base and 0.4% thymoquinone phytosomal gel was prepared. The phytosomal gel was evaluated. The stability study was performed, and phytosomal gel formulation was found stable at 4°C for 45 days.
Method development for Quantification of (S) - Isomer in Tenofovir Disoproxil Fumarate Bulk Drug and Formulations using Meta Substituted Phenyl Carbamate of Amylose as Chiral Selector
Authors: ALI SYED MASTAN , RAMACHANDRAN D.
Published: June 2022

The present paper involves developing a novel Chiral ultra-high performance liquid chromatographic (UPLC) technique for estimating Tenofovir Disoproxilfumarate (TDF) enantiomeric purity in both bulk and bulk dosage forms. The TDF is a pro drug employed in treating HIV in which the (R) isomer is active, while (S) isomer remains impurity and pharmacologically inactive. The UPLC method is categorized as a green chromatographic technique in which the chiral separation was achieved on ChiralpakIG-3(2.1x100mm) 3.0μm immobilized amylose column with meta substituted 3 chloro, 5 dimethyl phenyl carbamate as chiral selector, at a flow rate of 0.5ml/min using 0.5% diethylamine as an additive in hexane and ethanol. The influence of chiral additives and organic modifiers on enantio separation was investigated. The separation was analyzed on different columns for maximum resolution>10.0. The method was linear between within 0.25 to 7.5 μg.mL−1. The detection and quantification limits of (S) isomer were 0.08 μg.mL−1 and 0.25 μg.mL−1, respectively. Forced degradation studies were conducted and all the degradants were separated from drug peak. ICH guidelines validated the method.
Comparative Phyto-remedial effect of Zingiber officinale and Cuminum cyminum on hepatocytes of alloxan induced diabetic Mus musculus
Authors: Kumari Roushan , Singh Arun Kumar , Bharti Sudhanshu Kumar
Published: June 2022

Diabetes mellitus is a metabolic disorder that causes chronic hyperglycemia. Diabetes and its crippling complications are a significant cause of morbidity and mortality. This study evaluates the comparative antihyperglycemic and hepatoprotective effects of alcoholic extracts of rhizome of Zinger officinale plant and seed extract of Cuminum cyminum plant on alloxan-induced diabetic mice. Mice were divided into four groups (one normal control, one diabetic control and two diabetic groups treated with the two extracts). Mice were induced diabetes by intraperitoneal administration of alloxan. Normal control and diabetic control mice received normal saline water during the treatment period while diabetic mice were administrated with ethanolic extracts of ginger rhizome @100mg/kg/BW and cumin seeds extract @80mg/kg/BW for 16 weeks. At the end of the experiment, animals were sacrificed, and biochemical as well as histopathological examinations were carried out. Hyperglycaemia with increased SGPT and bilirubin have been observed in diabetic mice. However, normoglycemic conditions along with restored liver marker enzymes have been observed in diabetic rats treated with extracts. Histopathological examination showed that alloxan administration causes damage to hepatic cells. Conversely, in ginger and cumin-treated diabetic groups, a significant improvement in the architecture of hepatic cells has been observed, which showed the ability of the extracts to repair the damaged tissue. Thus, this study safely submitted that ginger and cumin significantly reduce the blood glucose level, with ginger having greater potential as a hepatoprotective agent than cumin.
Quantitative and Qualitative Assessment of Marketed Nutraceuticals for Active Ingredients and Heavy Metals for Safety and Efficacy
Authors: Bansal Rohit , Dhiman Anju
Published: June 2022

The global nutraceutical market is expanding fast, and people nowadays are inclined towards nutraceutical supplements for daily micronutrient needs and health benefits in some disease conditions. Hence, ensuring the safe and effective use of these supplements is the need of the hour. The current study is aimed at determining the accuracy and regulatory compliance of marketed nutraceutical formulations by quantifying the active nutraceutical ingredients and heavy metal content in these formulations using advanced analytical techniques. Total 12 marketed formulations were selected and analyzed in NABL (National Accreditation Board for Testing and Calibration Laboratories) accredited laboratory using High-performance liquid chromatography (HPLC) and inductively coupled plasma-mass-spectrometry (ICP-MS). The quantified values were compared with label-stated values and recommended values as per FSSAI. The quantified values in two lycopene samples varied significantly (-16 and +16%) from the label stated content and were found non-compliant with the regulatory recommendations. The measured intake values of calcium and vitamin D varied from 24 to 204% from the recommended daily allowances established by FSSAI. The quantified daily intake values varied from 4.2 to 58 mg and from 4 to 21.5 mg for lycopene and lutein, respectively. Heavy metal content determination resulted in two samples deviating from the tolerance limits of heavy metals for lead and arsenic. The mean values for lead and arsenic were found to be 2.482 ± 6.921 and 0.311 ± 0.655 ppm, respectively. The present study results provided vital information on the composition of marketed nutraceutical formulations. The regulatory agencies require stringent monitoring practices to ensure compliance with the existing regulatory guidelines to provide the consumer safe and effective nutraceutical products.
Design, Synthesis and Molecular Docking Study of N-Heterocyclic Chalcone Derivatives as an Anticancer Agents.
Authors: Fegade Bharti , Jadhav Shailaja B.
Published: June 2022

The Claisen-Schmidt condensation of 4-(aryl)-aminobenzaldehyde and 2-hydroxyacetophenone resulted in a new series of heterocyclic chalcone (4a-4g) derivatives. Nucleophilic aromatic substitution (SNAr) of 4-fluorobenzaldehyde with heterocycle amines by ultrasonication in the presence of a base and polar aprotic solvent yielded 4-(aryl)-aminobenzaldehydes. Spectral investigations were used to establish the structures of synthesized compounds. The in vitro anti-cancer activity of the synthesized derivative was evaluated against MCF-7 (breast cancer) cells by SRB assay. Compounds 4c, 4b, and 4c have a high affinity for the ER receptor binding site, whereas compounds 4c and 4g have a moderate affinity for the VEGER-2 receptor. The GI50 value of 4c ((E)-1-(2-hydroxyphenyl)-3-(4-(4-methylpiperazin-1-yl)-phenyl) prop-2-en-1-one) was 44.6 uM, while the GI50 value of all other derivatives was greater than 80 uM. These findings lay the groundwork for additional research into the combination's potential uses in cancer therapy.
Design and Evaluation of Gastro-Retentive Drug Delivery System for Glimepiride using Design of Experiment
Authors: Kumar Aseem , Dutt Rohit , Sharma Anil Kumar
Published: June 2022

Glimepiride, oral sulfonyl urea, BCS class-II drug is used to treat diabetes (type-II). Due to its low solubility, it is an ideal candidate for solubility enhancement, leading to better bioavailability and subsequent dose. In the present study, the solid dispersion technique was used to improve the solubility using solvent evaporation method. The solid dispersions were prepared using affnisol 912 as a solubility enhancer. The prepared solid dispersions were evaluated for solubility in 0.1N HCl pH 1.2 and phosphate buffer pH 7.8 medium. The solubility of glimepiride in optimized solid dispersion (SD1) formulation was 682.44 μg/mL compared to 6.88 μg/mL for pure drug in pH 7.8 medium. The solid dispersion (SD1) was further formulated into the tablets. The gastro-retentive and mucoadhesive properties were contributed to the tablets by HPMC K4M and Carbopol 940, respectively. Factorial design (Central composite design) was used to optimize the gastro-retentive tablets. The tablet formulations showed good mucoadhesive properties and drug release up to 12 hours in pH 1.2 with 0.5% SLS medium. The optimized formulation (F2) showed cumulative drug release up to 97.20 ± 0.99% in 12 hours. The drug release kinetics also showed that the drug is release by dissolution and diffusion from the drug matrix. The gastro-retention studies in rabbits also showed the tablets remain within the GIT up to 12 hours as confirmed by x-ray images.
Pengaruh Intensitas Penggunaan Aplikasi Tiktok dan Media Sosial terhadap Kecenderungan Phubbing
Authors: Solikhah Nuril Ilmiatus , Aesthetika Nur Maghfirah
Published: June 2022

Penggunaan gadget dan aplikasi media sosial kini membuat pengguna betah dalam menggunakan aplikasi dan cenderung memiliki perilaku Phubbing terhadap lingkungannya. Hal ini membawa suatu dampak yang negatif bagi remaja atau pengguna. Penelitian ini bertujuan untuk mengetahui sejauh mana sosial media dan aplikasi Tiktok ini mempengaruhi mahasiswa untuk terus bertahan dengan penggunaan dalam jangka waktu yang lama sehingga menyebabkan terjadinya Phubbing. Model penelitian Kuantitatif Deskriptif dengan menggunakan teknik pengambil sampel purposive sampling digunakan pada penelitian ini, sedangkan teknik analisa data mempergunakan validitas, regresi, dan uji asumsi klasik. Populasi studi ini ialah mahasiswa Universitas Muhammadiyah Sidoarjo (Umsida) dengan sampel 90 orang. Temuan penelitian adalah intensitas penggunaan Tiktok dan Instagram berpengaruh pada perilaku Phubbing mahasiswa Umsida. Dari kedua variabel penelitian, pengaruh paling besar ditimbulkan oleh penggunaan Tiktok, sebesar 70,3% sedangkan varibel penggunaan sosial media mendapatkan hasil 32%.
Wacana Edukasi Antirasisme pada Kanal YouTube DramatizeMe
Authors: Satiya Firli Daffa , Ferdiansyah Mayer Roland , Said Martriana P
Published: June 2022

Media sosial tidak hanya menjadi wadah penyebaran informasi umum, namun sering jadi wadah mengedukasi masyarakat dengan jangkauan yang luas. Salah satu media sosial yang memiliki banyak peran adalah YouTube yang dinilai mudah memberikan informasi dan edukasi dengan subtitle teks baik bahasa Indonesia maupun bahasa asing. YouTube juga dianggap sebagai salah satu media sosial yang dapat dengan cepat menyebarkan ideologi baru, termasuk ideologi antirasisme yang digaungkan oleh saluran YouTube DramatizeMe. Penelitian ini menggunakan pendekatan kualitatif dengan paradigma kritis untuk mengetahui individu tidak hanya belajar tentang dunia sosial, tetapi melihat keamanan tindakan untuk mengubahnya. Setiap peristiwa dianggap memiliki makna yang berbeda dan bertujuan membangun makna baru. Analisis yang digunakan adalah analisis wacana kritis Norman Fairclough. Teknik pengumpulan data melalui cuplikan adegan dan teks yang terdapat dalam video di kanal YouTube DramatizeMe. Temuan penelitian mengungkap adanya edukasi antirasis dalam kanal YouTube DramatizeMe. Pembuat video berusaha menggambarkan isu diskriminasi rasial dan gender dalam karya mereka itu sebagai bentuk pelanggaran hak asasi manusia dan layak mendapatkan perhatian publik yang lebih luas.
Model Kolaborasi Komunikasi Terapeutik Kiai dan Perawat Jiwa sebagai Media Kekuatan Pencapaian Realisasi Diri Orang dengan Gangguan Jiwa
Authors: Wahyuningsih Sri
Published: June 2022

Tujuan penelitian ini untuk mengetahui, menganalisis, dan menggali model kolaborasi kiai, kader jiwa, dan perawat jiwa sebagai media kekuatan pencapaian realisasi diri orang dengan gangguan jiwa (ODGJ). Paradigma konstruktivistik dengan jenis penelitian kualitatif deskriptif digunakan pada studi ini. Pendekatan penelitian menggunakan studi kasus instrumental tunggal. Subjek penelitiannya adalah kiai dan perawat jiwa, sedangkan objek penelitiannya ialah model kolaborasi komunikasi terapeutik kiai dan perawat jiwa sebagai media kekuatan pencapaian realisasi diri ODGJ. Teknik pengumpulan data menggunakan observasi, wawancara, dokumentasi, dan bahan audio visual. Teknik analisis data, diantaranya menciptakan dan mengorganisasikan file untuk data; membaca seluruh teks, membuat catatan pinggir, membentuk kode awal; mendiskripsikan kasus dan konteksnya; menggunakan agregasi kategorikal untuk membentuk tema dan pola; menggunakan penafsiran langsung; dan menyajikan gambaran mendalam tentang kasus dengan menggunakan narasi, tabel, dan gambar. Teknik keabsahan data menggunakan triangulasi sumber, metode, teori, dan member check. Lokasi penelitian di Panti Jiwa Bani Amrini, Bangkalan, Madura. Teori yang dipakai adalah teori Interaksi Simbolik George Herbert Mead: interaksi yang terjadi antara kiai, kader jiwa, dan perawat jiwa dengan ODGJ merupakah pertukaran simbol dan pesan yang bermakna guna realisasi diri ODGJ. Hasil penelitiannya adalah model kolaborasi antara kiai, kader jiwa dengan terapi psikoreligius, terapi air, terapi pra karya, terapi komunikasi harian, terapi pra karya dengan terapi suntik dan terapi obat, dengan dua cara yang berbeda untuk memberikan kekuatan realisasi diri ODGJ.
Proses Adaptasi Speech Codes dalam Komunikasi Interpersonal pada Pasangan Antaretnis Melayu
Authors: Hasbiran Meranti , Arrianie Lely
Published: June 2022

Perbedaan latar belakang budaya sering dijumpai dalam proses berkomunikasi, oleh karena itu diperlukan upaya khusus dari masing-masing peran untuk memperoleh saling pengertian. Tinjauan pustaka menggunakan paradigma interpretif untuk menjelaskan fenomena kasus yang bertemakan komunikasi antarbudaya menggunakan metode grounded theory dari Speech Codes Theory, dan teori pendukung yang diturunkan dari konsep adaptasi budaya yaitu model U-Curve pada salah satu The Integrative Models dalam konsep Adaptasi. Merujuk pada proses adaptasi yang dilakukan dalam studi penelitian, diasumsikan tokoh pelaku sebagai sosok migran sesuai dengan gagasan utama teori adaptasi kurva-U, karena telah melalui tiga tahapan atau fase yaitu: Antisipasi, Gegar Budaya dan Penyesuaian. Dalam mengatasi masalah komunikasi interpersonal pada pasangan multikultural antar etnis Melayu, studi ini merekomendasikan upaya praktis yang diadaptasi dari teori adaptasi budaya untuk beradaptasi dengan perbedaan kode bicara melalui asimilasi, pemisahan dan segregasi, integrasi dan marginalisasi.
Model Orientasi Pemasaran Politik sebagai Strategi Komunikasi Pemenangan Pemilu Legislatif
Authors: Zunaria Yuyun , Ruliana Poppy
Published: June 2022

Persaingan politik yang terbuka membuat masyarakat dihadapkan dengan banyak pilihan politik. Hal ini menuntut politisi mengemas strategi komunikasi politik, arah dan tujuan politiknya secara persuasif agar mampu menarik perhatian masyarakat. Pengemasan pesan politik merupakan salah satu elemen penting dalam melaksanakan kampanye politik. Penelitian ini bertujuan untuk memahami dan mendeskripsikan model orientasi pemasaran politik sebagai strategi komunikasi politik. Konsep model orientasi pemasaran politik Lees-Marshment digunakan pada penelitian ini. Studi ini berfokus pada masa kampanye pemilihan legislatif di derah pemilihan lima Provinsi Jawa Tengah tahun 2019, khususnya di tiga kabupaten yakni Boyolali, Klaten, Sukoharjo, dan Kota Surakarta. Penelitian ini berlandaskan paradigma interpretif dengan menggunakan pendekatan kualitatif, dan metode studi kasus. Pengumpulan data dilakukan melalui tahapan observasi partisipan, wawancara mendalam dengan informan kunci AB, dan tiga orang tim sukses sebagai informan yang terlibat dalam keberhasilan pemenangan pemilu legislatif di dapil lima Jawa Tengah: DN, YY, dan FR. Selanjutnya mengumpulkan dokumen-dokumen dan studi pustaka untuk memperoleh informasi dan data yang relevan dengan penelitian ini, seperti buku-buku, jurnal, dan penelusuran melalui internet. Teknik analisis data dilakukan dengan menggunakan model Miles dan Huberman, yaitu reduksi data, display, dan verifikasi/kesimpulan. Triangulasi dilakukan untuk memperoleh kedalaman informasi/data di lapangan. Hasil penelitian mengungkapkan, tahapan dalam model pemasaran politik sebagai strategi komunikasi politik yang diterapkan dalam penelitian ini menitikberatkan pada komunikasi interpersonal yang sifatnya partipatif kepada masyarakat pemilih untuk memenangi pemiluhan umum  legislatif tahun 2019 di Daerah Pemilihan V Provonsi Jawa Tengah.
Analisis Jaringan Komunikasi pada Tagar #KPKEndGame di Media Sosial Twitter
Authors: Priambodo Aditya Ilham , Arianto Irwan Dwi
Published: June 2022

Isu Tes Wawasan Kebangsaan (TWK) KPK menjadi topik yang ramai dibicarakan khalayak umum. Pada media sosial Twitter muncul tagar #KPKEndGame yang menjadi trending topic pada periode waktu tertentu. Munculnya tagar #KPKEndGame sebagai trending membuka ruang diskusi bagi khalayak umum untuk berinteraksi serta menyuarakan opini-opininya terkait isu TWK. Interaksi yang terjadi tersebut membentuk sebuah jaringan komunikasi. Penelitian ini bertujuan memetakan jaringan komunikasi dari isu TWK KPK dengan menggunakan kata kunci #KPKEndGame berlandaskan analisis jaringan komunikasi Eriyanto dan didalami lebih lanjut dengan level analisis dari Suratnoadji Arianto yaitu level konten, level perilaku, serta level jaringan. Penelitian ini menemukan, kata kunci #KPKEndGame banyak digunakan mulai 28 Mei 2021 dan terus memuncak pada 29 hingga 30 Mei 2021. Terdapat 8.255 vertices serta 18.214 relasi yang terdiri dari 5.338 edges dan 12.876 unique edges. Terbentuk lima cluster utama dengan masing-masing influencer dan cluster keenam yang tidak memiliki influencer. Aktor utama dalam jaringan #KPKEndGame adalah akun @kpk_endgame. Sebagai aktor utama, @kpk_endgame dapat berperan secara efektif dalam menyampaikan serta mengontrol persebaran pesan dan informasi dalam jaringan sehingga dapat menentukan arah opini masyarakat terkait isu ini yang didominasi dengan sentimen negatif.
Fungsi Pembelajaran Media Sosial Youtube dalam Mencerdaskan Kehidupan Bangsa
Authors: Yuniar Ririt , Fajri Tiara Rosana Nurul
Published: June 2022

Optimalisasi fungsi media pada Youtube Kemendikbud RI sebagai fungsi pembelajaran guna mencerdaskan kehidupan Bangsa yang dicita-citakan oleh Bangsa Indonesia termaktub dalam Pembukaan Undang-Undang Dasar 1945 perlu mendapat perhatian dan peningkatan. Metode yang digunakan dalam penelitian ini adalah analisis wacana Fairclough. Temuan penelitian ini adalah fungsi media sebagai informasi, pendidikan, persuasi, hiburan, dan sebagai pilar keempat demokrasi sudah dijalankan dengan baik dalam video yang diunggah channel Youtube Kemendikbud RI. Namun fungsi media sebagai kontrol sosial belum direpresentasikan dengan baik dalam video tersebut. Dari berbagai fungsi media yang ditemukan, fungsi media sebagai pendidikan menjadi fokus pembahasan yang dianalisis lebih mendalam dalam tulisan ini. Maka dari itu hasil studi memperlihatkan sebagian besar fungsi media sudah dioptimalkan oleh Youtube Kemendikbud RI, namun terjadi disfungsi pada fungsi kontrol sosial, yang mana fungsi tersebut belum begitu tampak. Keterbatasan dalam penelitian ini adalah data yang didapatkan masih relatif kecil, yaitu video dalam kurun waktu Februari – Juli 2021, dan hanya mengulas satu video saja. Namun demikian, data yang digunakan dalam penelitian ini cukup komprehensif karena mengungkap feedback yang diberikan audiens baik berupa tanggapan, apresiasi, dukungan, pertanyaan, harapan, kritik, saran, aduan, dan daerah. Sehingga diperlukan penelitian lebih mendalam yang berkaitan tentang fungsi media Youtube dalam mencerdaskan kehidupan bangsa. Spesifik pada konten-konten yang mengarah sasaran audiens, misalnya anak muda, pendidik, atau masyarakat umum, sehingga konten tersebut dapat dirasakan manfaatnya oleh seluruh Bangsa Indonesia dari Sabang sampai Merauke.
Netnography Study: Racism Against TikTok Account @mingokwamkilama16
Authors: Febty Inggi Miya , Qodir Zuly
Published: June 2022

The purpose of this study is to find out what types of racism are experienced by TikTok users who have an account named @mingokwamkilama16. This research is to find out what racist words are expressed by TikTok users. Besides that, it also wants to find out what types of racism are happening. This study uses a descriptive qualitative approach to analyze social media data, namely with NVivo 12Plus to analyze TikTok social media content and data. The data is taken from the TikTok account @mingokwamkilama16, consists of 5 contents, and gets data of 50 discriminatory comments. The results show that the Papuan tribe often experiences acts of racism when using social media, such as creating content on the Tiktok application, and creating an @mingokwamkilama16 account, which is often discriminated against by other Tiktok users. Of the three indicators studied, the most dominant is discrimination on race, which reaches 70% of the data. This shows that racial discrimination is prevalent, this attitude can make account users feel hurt, and many are physically disturbed. Papuan people are also part of Indonesia, but Indonesian people are also racist toward them. There are still many Tiktok users who lack education about Indonesian races.
Akumulasi Modal Manusia, Pemanfaatan Remitan dan Kendala Pemanfaatannya dalam Peningkatan Kesejahteraan Rumah Tangga Migran kembali di Kabupaten Cilacap
Authors: Suyanto Suyanto , Falah Fajrul
Published: June 2022

Return migrants in some areas of migrant’s enclave in Indonesia a have high dependence on work abroad because when they return to Indonesia many no longer have a steady source of income. This happens because they are generally consumptive, spend a lot of money, are glamourous, are less calculating, not have a job plan after not being a migrant. For this reason, the use of remittances migrants is again interesting to study. The aims of this research are to explain the utilization of remittances and the obstacle experienced in the utilization of remittances in improving the welfare of households. The design of this study was a survey and case study. Data collection uses observation, structured interview, in-depth interviews, and FGD. Data analysis uses descriptive statistics and followed by qualitative descriptive and categorical analysis. The result of the research shows that remittances are generally for buying land and building houses, furniture and modern kitchen equipment, motorbikes or cars, and wedding parties, and a small portion is allocated for productive businesses. An obstacle of returning migrants in improving their welfare household is low education, the use of more remittances for consumer goods and investment, and the use of remittances more determined by husbands.
Penguatan Fungsi Keluarga Pada Masa Pandemi Covid-19 di Kota Tanjungpinang Provinsi Kepulauan Riau
Authors: Husni Alfi , Rinah Sri Ambar , Prastiyo Endri Bagus
Published: June 2022

The Covid-19 pandemic in Indonesia has had an impact on the current order of human life, so there must be a strengthening of the family by referring to the seven functions of the family. The problem in this study is that there is an influence of the COVID-19 pandemic situation on the order of family life, one of which is from family income, so this is important given the economic function in a family, and of course other family functions will also be affected. Tanjungpinang City is one of the cities that has a pluralistic society, this is certainly an interesting study considering that Tanjungpinang City, which is located on Bintan Island, is the capital of the Riau Archipelago Province. The purpose of this study was to see the strengthening of family functions during the COVID-19 pandemic in the Tanjungpinang Timur sub-district, Tanjungpinang City, Riau Islands. The method used in this research is a qualitative descriptive approach. The technique used to collect data is in-depth interviews and field observations. Informants were taken using a purposive sampling technique, where the informants to be interviewed were families who were directly affected by the COVID-19 pandemic, such as family members who were laid off, affected by the business they were in and other problems in the family that arose during the COVID-19 pandemic. The results of this study are that there is a strengthening of family functions during the COVID-19 pandemic in Tanjungpinang City, especially for the research area, namely East Tanjungpinang sub-district.
Location Characteristics of the New Country Capital in East Kalimantan Province
Authors: Kumalati Rosalina , Yuliarti Astinana , Ali Syamani D , Murliawan Karnanto Hendra , Rahman Abd , Arief Ogie Elian Aziz , Muza Muhammad Naufal , Rinaldi Sahrul , Anggraini Rizky Nurita
Published: June 2022

The relocation of the national capital has been carried out by several countries for various reasons. This study aimed to determine the characteristics of the location of the nation’s capital city in East Kalimantan Province. The research was conducted in two regencies, 3 sub-districts, and 4 sub-districts. Penajam Paser Utara District includes Babulu and Sepaku Districts, while Kutai Kartanegara District includes Muara Jawa District. The data used in this study is secondary data from the study literature. The findings from the study are that in West Babulu Village there is a network of arterial roads and local roads. Pemaluan Village, Sepaku Village, and Teluk Dalam Village have a network of local roads and other roads. North Panajam Paser Regency has 3 watersheds and Kutai Kartanegara Regency has 2 watersheds in total there are 5 watersheds. Meeting water needs apart from river water can also be from dams. In 2023, it is estimated that the Nation Capital's water needs will reach 16,500 liters/second, with the needs of surrounding districts in that year reaching 27,232 liters/second. In line with the development of the city and its facilities, the need for water will increase, so the nation’s capital city requires alternative sources of additional water. Topographic conditions seen from elevation, slope, and landform, there are several areas that need to be maintained as protected areas or city green open spaces (RTH), urban forests, which can also function as educational or tourism facilities for Capital cities in order to protect areas that are underneath
A Rational Choice Analysis in Offering The Spirit of The Northern Buddhism
Authors: Nguyen Khang Tan , Harahap Junardi , Rajab Budi
Published: June 2022

Offering the spirits in the ritual system of Northern Buddhism is a ritual performed daily for monks and an opportunity for Buddhists to participate in many different purposes. In it, there is an exchange between gain and loss while performing the ritual of offering the spirit. It could be said that based on the concepts and beliefs about ghosts and demons in Mong Son thi thuc - one of the important rites in the customs of Northern Buddhists - these rituals give us a deeper insight into the act of worshiping the souls. This research investigates the rational choice of Northern Buddhists in Ho Chi Minh City-based on Rational Choice Theory. Qualitative research methods such as fieldwork, in-depth interviews, qualitative analysis, and quantitative research by questionnaires have shown that there is rationality in the choice of worship the souls according to Mong Son thi thuc of Northern Buddhists among believers. In other words, there seems to be a desire to receive one or more benefits from this spirit offering. Rational Choice Theory has shown its applicability in the study of rituals, religions in particular, and in the research of the humanities and social sciences in general, which has received little attention in the past.
Young Offender Resistance Towards State hegemonic Practices: Case Study of “LPKA Belantara”
Authors: Maxey William Edward , Setiawati Sri , Arifin Zainal
Published: June 2022

The purpose of this article is to describe the resistance of young offenders toward hegemonic practices of the State. Following qualitative research practices with a descriptive design, this article employs the concept of habitus to analyze the nexus of actor and agency within the field of Belantara Young Offender Institution and the processes formed from resistance within the space. The findings show that young offenders attempt to resist the State’s control as they thwart the goals and values of the dominant power. The resistance of young offenders within Belantara Young Offender Institution consists of control of space, shaping discourse, rule-breaking, open defiance, conformity, and foot-dragging. Due to the imbalance of power between young offenders as a subaltern group and the staff at Belantara Young Offender Institution as the dominant group, the young offenders resist primarily through the hidden transcript. The data show a cycle of hegemony and resistance maintained by both groups which form a set of resistance. The research suggests the State reassess whether young offender institutions are the best place for young offenders as the cycle of hegemony and resistance creates a setting that cannot adequately rehabilitate.
DInamika Identitas Betawi Kristiani di Kampung Sawah, Bekasi
Authors: Noorbani Muhammad Agus , Halimatusa'diah Halimatusa'diah
Published: June 2022

This paper presents the results of research on the Betawi Christian community in Kampung Sawah, Kota Bekasi. Based on interviews and literature study, this paper aims to analyze the dynamics of the identity of the people of Kampung Sawah and the acceptance of the Betawi Muslims towards them. The results of this study found that the Betawi identity continues to develop alongside the development of the residential area of this ethnic community and the flow of migration. The widespread motivation of scholars regarding the origins of the emergence of this ethnic group shows that this ethnic group is difficult to define as a result of the wide interaction between ethnic members and other ethnic groups. Because the identity of the Betawi is something that is fluid, the Betawi Christian of Kampung Sawah community can also be referred to as a part of the Betawi community. They shared Betawi identity and culture with other members of Betawi community as general.
Tradisi Bona Taon Suku Batak Toba Di Perkotaan: Antara Kekerabatan Dan Citra
Authors: Siregar Mangihut
Published: June 2022

Kinship is essential for the Toba Batak tribe. To maintain kinship, good relations between those who live in the area of origin and those who live in the overseas (urban) areas are always maintained. This sound kinship brings traditions from the area of origin to the overseas area. One of the exciting traditions to study is the Bona Taon. This tradition has long been lost in the area of origin but is increasingly existent in urban areas. The Bona Taon tradition was lost because of the prohibition by the Dutch colonialists. This study examines the Bona Taon tradition of urban-plan models using globalization theory and hypersemiotic theory. The results show that the Bona Taon tradition carried out by the Batak tribe in urban areas aims to strengthen kinship relationships that are full of images. In practice, this tradition has changed from what was originally sacred to only entertainment.
Tragedi dalam Harmoni: Budaya, Gender, dan Kekerasan pada Perempuan di Jawa Barat
Authors: Yulianingsih Yulianingsih , Herawati Erna
Published: June 2022

People in West Java uphold harmony and peace as an important part of their worldview. Yet, violence against women continues to occur, including in rural areas. This qualitative research using a case study design was conducted to explore and describe the cases of violence against women and the factors contributing to the case in Desa Selaras, a small village in rural West Java. The data were collected through observation and in-depth interviews with female violence survivors and NGO activists who assist them; as well as archival and literature studies. The findings of this research suggest the various types of violence against women, such as psychological violence (polygamy), physical violence (persecution), economic violence (economic exploitation and financial neglect), and sexual violence. Among the factors contributing to the violence in the village were gender inequality, financial problems, lack of knowledge and passive attitudes towards violence among the survivors, cultural values about women, lack of communication in the family, and male personality.
The Effect Of Mobile Map With Geospatial Technologies On The Development Of Blind Disabilities’s Spatial Relational Thinking
Authors: Amrullah Muhammad Erwin Amrullah , Ramdani Fatwa , Tolle Herman
Published: June 2022

Orang tunanetra mungkin mengalami masalah saat berkunjung dari satu tempat ke tempat lain. Satu masalah umum yang mereka hadapi adalah mereka kesulitan membiasakan diri dengan tempat-tempat yang mereka kunjungi. Bagi masyarakat pada umumnya, masalah tersebut dapat diatasi dengan menggunakan peta. Kendati demikian, solusi penyandang tunanetra seperti itu mungkin bukan solusi terbaik karena peta yang bisa digunakan oleh tunanetra tersebut adalah peta taktil. Peta taktil memiliki banyak kekurangan, salah satunya adalah sulitnya mendapatkan update ketika terjadi perubahan pada area karena peta taktil belum terdigitalisasi untuk aplikasi mobile. Oleh karena itu, perlu dibuat peta berbasis aplikasi mobile untuk memudahkan penyandang tunanetra. Penelitian ini akan memfokuskan pada peta digital yang dapat diakses melalui aplikasi mobile dengan pendekatan Extreme Programming (XP) serta studi kasus yang dilakukan di Universitas Brawijaya. Peta digital yang dikembangkan nantinya akan diujicobakan kepada responden untuk diuji kelayakannya sehingga dapat membantu meningkatkan pemahaman spasial para penyandang tunanetra khususnya di wilayah Universitas Brawijaya. Lebih penting lagi, diharapkan dapat membantu para penyandang tunanetra di sekitar Universitas Brawijaya untuk membiasakan diri dengan lingkungan sekitarnya.
Early drought-resistant soybean variety Lyubava
Authors:   V.S. Pustovoit All-Russian Research Institute of Oil Crops, Zelentsov S.V. , Moshnenko E.V. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops, Budnikov E.N. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops, Saenko G.M. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops, Trunova M.V. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops, Bubnova L.A. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops, Savichenko V.G. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops
Published: June 2022

The early soybean variety Lyubava was obtained as a result of individual selection in F4 from the hybrid combination Vilana × D-7/10 on a differentiating background on the basis of increased drought resistance. According to the results of variety trial in 2018–2021, the variety Lyubava with an average yield of 2.39 t/ha exceeded the standard variety Slavia by 0.33 t/ha. Plant height at the latitude of Krasnodar (45°) is 90–115 cm. The new soybean variety Lyubava is tall and has a deep root system, which provides it with increased drought resistance. Due to the reduced photoperiod sensitivity, the Lyubava variety is suitable as a second summer crop at latitudes of 45 ± 2° without a significant decrease in plant height and yield. Such physiological and genetic features determine its potential attractiveness for cultivation in soybean-producing farms of the North Caucasus, Central Chernozem and Lower Vol-ga regions of the Russian Federation
Peppermint variety Rozovskaya Aroma
Authors:   V.S. Pustovoit All-Russian Research Institute of Oil Crops, Shuvaeva T.P. , Gaytotina I.V. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops, Zelentsov S.V. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops, Moshnenko E.V. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops, Saenko G.M. ,   V.S. Pustovoit All-Russian Research Institute of Oil Crops
Published: June 2022

The original plant of the peppermint variety Rozovskaya Aroma was obtained by vegetative propagation of cuttings of a mutant shoot with traits of increased length and altered leaf shape, discovered in 2010 on the variety Pamyat' Reznikovoy. As a result of vegetative propagation of cuttings, the breeding line L-9.24.455 was obtained, which received the commercial name "Rozovskaya Aroma". Based on the results of the variety trial of 2017–2019, the variety Rozovskaya Aroma exceeded the standard variety Vesna by 5.93 t/ha in terms of biomass yield. The shape of the bush of the variety Rozovskaya Aroma is semi-closed. Plant height is up to 95 cm. Leafiness degree 57.8%. The shape of the leaf blades is oval-rhombic, the color is green. The surface of the leaf is smooth, without pubescence. The size of the leaf blades is 6.0–7.0 × 2.5–3.5 cm. The inflorescence is loose, spike-shaped, with spaced whorls. The length of the inflorescences is 14–16 cm. Flowers are almost sterile. The color of the corolla of the flower is light pink. Stamens have undeveloped pollen sacs, and are longer than the corolla. The shape of the teeth of the calyx is triangular. The pubescence of the calyx is almost absent. The peppermint variety Rozovskaya Aroma is distinguished by a high content of essential oil in biomass – up to 4.70% and high yield of essential oil – up to 93.9 kg/ha. In 2020, the variety Ro-zovskaya Aroma was included in the State Register of Breeding Achievements and approved for cultivation in all regions of the Russian Federation.
The impact of COVID-19 on orthodontic postgraduate programs in Balkan countries: Results from an international survey by orthodontic residents
Authors:   Department of Orthodontics, Faculty of Dentistry, “Grigore T. Popa” University of Medicine and Pharmacy of Jassy, Jassy, Romania, Karvelas Nikolaos , Karkazi Frantzeska ,   Department of Orthodontics, School of Health Sciences, Faculty of Dentistry, Marmara University, Istanbul, Turkey, Papadopoulos Moschos A. ,   Department of Orthodontics, School of Dentistry, Aristotle University of Thessaloniki, Greece, Zetu Irina Nicoleta ,   Department of Orthodontics, Faculty of Dentistry, “Grigore T. Popa” University of Medicine and Pharmacy of Jassy, Jassy, Romania, Özdemir Fulya ,   Department of Orthodontics, School of Health Sciences, Faculty of Dentistry, Marmara University, Istanbul, Turkey
Published: June 2022

Design Multidisciplinary survey conducted via a web-based questionnaire for orthodontic postgraduate students. Settings Orthodontic residents from 9 countries were surveyed between April and May 2021. The majority was from Romania 52.53% (n=83), Turkey 21.52% (n=34), Croatia 6.33 (n=10) and less than 5% of participants from the other countries with Bulgaria 4.43% (n=7), Republic of Moldova 4.43% (n=7), Greece 3.80% (n=6), Bosnia and Herzegovina 3.16%(n=5), North Macedonia 1.90% (n=3) and Serbia 1.90% (n=3). Results The questionnaire was completed by 158 orthodontic postgraduate students from the Balkan countries, of which 75.95% (n=120) were females and 24.05% (n=38) were males. The average age group of the respondents was between 25-34 years (84.81% [n=134] of the participants), while there was a significant difference (p<0.05) with students from Romania with 2.3 times more females from Turkey with 2.4 times more males in comparison to other countries. A higher number of the participants 37.34% (n=59) were working in both the private and public sectors. Most of the orthodontic residents were mostly in their 2nd year of studies 72.78% (n=115). The majority of the postgraduate students (n=93, 58.86%) altered their plans and service delivery following the instructions of their institutions. The impact of coronavirus was evident, since a decrease in outpatient visits before and after the pandemic was evident, (from 15 patients to 12 patients respectively per day), with an average of 6 working hours under current circumstances. Conclusions In this first international survey for orthodontic residents, widespread changes in the orthodontic education programs during the outbreak of COVID-19 are reported.
Pengembangan Instrumen Tes Kemampuan Berpikir Analisis Pada Materi Akhlak Terpuji Dalam Pergaulan Remaja
Authors: Diki Diki Mulyana , Farida Ida , Hardiansyah Darius
Published: June 2022

The quality of the cognitive learning outcomes instrument is one of the prerequisites that must be considered by the teacher before evaluating student learning outcomes. However, the reality in the field is that some of the learning outcomes instruments used do not seem to have applied the appropriate rules. This study aims to develop a test instrument for analytical thinking skills in Akidah Akhlak subjects, commendable morals in adolescent association. This research was carried out at MTs Miftahul Huda in Bandung, involving 31 students. The method used in this study is Research and Development (R&D) with the ADDIE model. The instruments developed are oriented to analytical thinking skills. Based on the test results obtained (1) All test items (12 items) are valid both content and construct, while based on the empirical validity test 3 items are declared invalid; (2) the reliability coefficient is 0.786 at a significance of 0.05 has a high level of reliability; (3) the difficulty index of the items in the easy category with a percentage of 60% and the medium category 40%; (4) the discrepancy index of 13 items is categorized as good with the calculation results showing a positive value; and (5) the effectiveness of the distractor is stated that the 13 item questions or as much as 75% of the distractors function well, while 2 items or 25% must be corrected. Thus, the developed instrument is suitable to be used as an analytical thinking ability test instrument.
Effectiveness Of Using Village Funds In Improving Village Status Based On The Building Village Index (Idm) In Kuantan Singingi Regency
Authors: Kurniawan Andri , Rauf Rahyunir
Published: June 2022

The Village Building Index in its application is used to map village development and independence based on the implementation of village laws. The index of developing villages is measured through three indicators, namely indicators of economic resilience, indicators of environmental resilience and indicators of social resilience. Identification of problems related to the effectiveness of using village funds based on the developing village index (IDM) in Kuantan Singingi Regency has not been effective, besides that the village government has obstacles in the use of village funds. The purpose of this study was to determine how effective the use of village funds was in improving village status based on the developing village index (IDM) in Kuantan Singingi Regency. Data collection techniques used in this study are through observation, interviews and documentation. Based on the results of the study, it shows that the effectiveness of using village funds in improving village status based on the developing village index (IDM) in Kuantan Singingi Regency is assessed according to the principle of using village funds according to village laws, namely to create villages with independent qualifications.
Community Self-Efficacy Relationship to COVID-19 Vaccination at Puskesmas Siak Hulu I Kampar Regency in 2021
Authors: Nopriadi Nopriadi , Rustam Musfardi , Fitri Aminatul
Published: June 2022

The high massive transmission of COVID-19 occurs great numerous of mortality and morbidity. It is caused by low coverage of COVID-19 vaccinations that are continuously pursued by the Indonesian government. This can be identified by health promotion based on community self-efficacy as effective prevention of COVID-19 has not been fully implemented. Public understanding and perception of the prevention of COVID-19 are highly expected. Public confidence or known self-efficacy is needed in supporting COVID-19 vaccination.  This study aims to find out the relationship of community self-efficacy to COVID-19 vaccination at the Siak Hulu I Health Center in Kampar Regency in 2021. This was an analytic quantitative study with a cross-sectional approach to 209 participants which was taken by simple random sampling technique in Puskesmas Siak Hulu I. Based on the chi-square test result, it was found a relationship between self-efficacy and COVID-19 vaccination. The results showed that a person has a high self-efficacy greater than 5 times more vaccination than someone who has low self-efficacy. It is recommended to increase self-efficacy through good and easy-to-understand health communication about COVID-19 vaccination in the community.