bluuebunny/crossref_metadata_2025 huggingface dataset:
LES XANTHOMATOSES HYPERLIPIDEMIQUES: AU-DELA DE LA RARETE, QUELLE PRISE EN CHARGE ?
Authors:   Endocrinology, Diabetology and Metabolic Diseases Department Avicenna Military Hospital, Marrakech., Idrissi Ayoub , El Jadi Hamza ,   Endocrinology, Diabetology and Metabolic Diseases Department Avicenna Military Hospital, Marrakech., Abainou Lahoussaine ,   Endocrinology, Diabetology and Metabolic Diseases Department Avicenna Military Hospital, Marrakech., Elhadri Sanae ,   Endocrinology, Diabetology and Metabolic Diseases Department Avicenna Military Hospital, Marrakech., Meftah Azzelarab ,   Endocrinology, Diabetology and Metabolic Diseases Department Avicenna Military Hospital, Marrakech., Baizri Hicham ,   Endocrinology, Diabetology and Metabolic Diseases Department Avicenna Military Hospital, Marrakech.
Published: October 2023

Xanthomas are benign pseudo tumors, often linked to a disorder of lipoprotein metabolism and which require screening.We report the case of a 33-year-old young adult, with no significant medical history, who consulted for painless yellowish nodules progressively appearing over the past year on the limbs. Cutaneous and mucosal examination reveals small smooth-surfaced nodules, orange-yellow in color, painless, non-pruritic, of varying sizes, located on the forearms, elbows, hands, knees, ears and posterior surface of the neck. The histopathological study of a skin nodule biopsy suggests lipid overload, confirming the diagnosis of xanthomas. The lipid profile, conducted after a 12-hour fast, shows hypertriglyceridemia at 10.28 g/L, hypercholesterolemia at 7.79 g/L, elevated LDL cholesterol levels at 3.64 g/L and decreased HDL cholesterol levels at 0.31 g/L. Thyroid function tests and cardiovascular investigations are unremarkable. The diagnosis of familial combined hyperlipidemia type III, according to the Fredrickson classification is established.The patient is prescribed lifestyle modifications along with treatment consisting of daily pravastatin 40mg and fenofibrate 160mg. The patients condition shows improvement with regression of these lesions.Xanthomatoses linked to familial hypercholesterolemia are very rare. This condition can significantly impact patients lives due to its complications, particularly coronary complications, despite well-managed medical treatment.
ESSAI D EVALUATION DES PARAMETRES AGROMORPHOLOGIQUES DE L AUBERGINE (SOLANUMAETHIOPICUM L.) SOUMISE AU TRAITEMENT ORGANIQUE
Authors:   Ecole Normale Superieure de Bongor. Departement des Sciences de la Vie et de la Terre. BP 15 Bongor (Tchad)., Ignassou Alain Djinet , Francois Ganon ,   Ecole Normale Superieure de Ndjamena (ENS/NDJ). Departement de Chimie. BP 206 Ndjamena(Tchad)., Mberdoum Memti Nguinambaye ,   Universite de Ndjamena. Faculte des Sciences Exactes et Appliquees. Departement de Biologie. BP 1117 Ndjamena (Tchad)., Josue Roh ,   Ecole Normale Superieure de Bongor. Departement des Sciences de la Vie et de la Terre. BP 15 Bongor (Tchad).
Published: October 2023

La culture de laubergine est confrontee a des difficultes liees a lutilisation de lengrais chimique. Ces engrais sont chers et souvent non disponibles. En outre, les etudes ont montre que lengrais chimique a un effet negatif sur la qualite organoleptique et la conservation des aliments. Cela ne garantit ainsi pas la qualite nutritionnelle de laliment. Loption de lutilisation de lengrais organique reste la meilleure alternative. Letude a pour but devaluer linfluence des differentes doses de la bouse de vache sur les parametres morphologiques, agro-phenologique de laubergine afin de determiner la dose optimale pour sa bonne production. Pour cela, la hauteur de la tige principale et le diametre au collet ont ete mesures et les vitesses de croissances associees ont ete calculees. Le nombre des fleurs et fruits, le poids des fruits ont ete releves. La matiere seche des fruits et la matiere seche de la biomasse aerienne ont ete determinees et le rendement a ete estime.Des resultats, il ressort que les vitesses maximales de croissance ont varie entre le 42eme et 70eme jour apres repiquage pour la hauteur et entre le 42eme et le 56eme jour apres repiquage pour le diametre au collet. Pour tous les parametres etudies, les plants ayant reÃƒÂ§u 50 g de bouse de vache se sont montres plus performants comparativement aux autres.
PURITY OF MIND IS CONDITION PRECEDENT FOR REALIZATION OF ATMAN OR BRAHMAN - THE GREAT AND TIMELESS WORK OF AADHISANKARACHARYA ON APAROKSH ANUBHUTI IN COMPARISON WITH ATMABODA AND BAJAGOVINDAM
Authors:   Deputy Registrar (Academic Courses) Indian Institute of Technology Madras, Tamil Nadu South India, Chennai-600036., Sarvaharana P. , Manikandan S. ,   Assistant Professor and Head, Department of Philosophy A.M. Jain Arts and Science College Tamil Nadu South India Meenambakkam Chennai-600 027.
Published: October 2023

The word meditation is admired with awe and majesty by many in the world. Perhaps it is an unique word loved by millions in the world irrespective of cast, colour or creed. However, many confuse themselves with the practice of yoga and meditation. The word Yoga when it stands alone would denote asanas i.e. physical exercises. In this paper the various nuances contemplated by Aadhisankaracharya in his wonderful work the Aparoksh Anubhuti are discussed in comparasion with other works such as Atmabodha and Bajagovindam. In this work the Aacharya categorically contemplates what is the objective and scope of meditation and how to realize the Atman - ground work after ground work. This paper postulates such ground works that will indicate Purity of Mind is Condition Precedent for Realization of Brahman which has been emphatically emphasized in the great and timeless work i.e. APAROKSH ANUBHUTI. Comparison made in this paper is only to make the subject matter interesting. One should prepare well for meditation by cleansing the impurities of mind through the practice enunciated by the Aacharya and explore the possibility of meditation with clear understanding.
CHALLENGESOF OEM MANUFACTURER IN HALAL COSMETIC PRODUCTS CERTIFICATION APPLICATIONS
Authors:   Academy of Contemporary Islamic Studies, Universiti Teknologi MARA,40450 Shah Alam, Selangor, Malaysia., Husna Bt Mazril Suzaimi Nursyifa , Huda Sahari Noorul ,   Academy of Contemporary Islamic Studies, Universiti Teknologi MARA,40450 Shah Alam, Selangor, Malaysia., Ramlan Nadiah ,   Academy of Contemporary Islamic Studies, Universiti Teknologi MARA,40450 Shah Alam, Selangor, Malaysia.
Published: October 2023

As the 2.4 billion Muslim consumers around the world want more halal cosmetics, Malaysia is creating many cosmetics founders, both Muslim and non-Muslim, who push cosmetics with halal certification to help educate consumers about halal cosmetics. With an Original Equipment Manufacturer(OEM)manufacturing business, the business founder can have their own brand of cosmetics even they do not have a factory. OEM is a business that makes products based on what the founders desired. The OEM manufacturer will manage every procedure involved in producing a cosmetic product, including for getting halal certification. For the cosmetics to be halal certified, most OEM manufacturing companies will face a variety of procedures, one of them is due to the involvement of different cosmetics products thus, different requirement involved. It will not be easy, and the manufacturer must face a lot of challenges during the application process. The aim of this research is to explore about the problems faced by the OEM manufacturer, Anjung Skincare Solution SdnBhd, during the halal cosmetics certification process and how the problems have beensolvedthroughout the process. This study adopts a qualitative method where semi structured interview has been conducted to selected representatives who are the workers at the cosmetics company to identifythe application process that theyexperienced, problems faced and the solution taken. The data collected through interview has been analysed using thematic analysis. The finding shows that the staff who made the application understand exactly which references and criteris thatneeded to be used for halal certification of cosmetics products. Based on the analysis, Anjung Skincare Solution SdnBhds solutions and strategies are working well to help them deal with the problems. Each employee plays an important part as an agent in spreading the use of halal cosmetics. This research is expected to guide more cosmetics manufacturers to understand the challenges in getting halal certifications, besides the solutions to solve the issues.
JUVENILE OSSIFYING FIBROMA: NOT SO JEJUNE
Authors:   Assistant Professor Dept. Oral Pathology & Oral Microbiology Subharti Dental College & Hospital, Swami Vivekanand Subharti University, Meerut., Singh Roli , Wadhwan Vijay ,   Professor& Head Dept. Oral Pathology & Oral Microbiology Subharti Dental College & Hospital, Swami Vivekanand Subharti University, Meerut., Mustafa Sana ,   Intern Subharti Dental College & Hospital, Swami Vivekanand Subharti University, Meerut.
Published: October 2023

Juvenile ossifying fibroma (JOF) is a rare benign fibroosseous tumor which involves maxilla more than mandible. It usually occurs in children below 15 years of age. It is locally aggressive with significant growth potential which can raise fears of malignant pathology. This article reports a case of JOF occurring in the maxilla followed by surgical treatment.
SWOT ANALYSIS
Authors:   Assistant Professor, BGS B.Ed. College, Mysuru, Karnataka, India., Kumar C.R Sharath , K.B Praveena ,   Registrar of Evaluation, Karnataka State Open University, Mysuru, Karnataka, India.
Published: October 2023

SWOT Analysis is an analysis method used to evaluate the Strengths, Weaknesses, Opportunities and Threats involved in an organization, a plan, a project, a program, a person or any kind of business activities. SWOT Analysis is the most commonly used strategic planning tool to access the Internal and External factors of any organization. This is considered as an effective framework plan and mange the organizational resource to achieve certain goals in a specific period of time. The purpose of the implementing SWOT analysis in an organization is to formulate the strategy of business based on existing internal and external factors. This articles provides a study of SWOT Analysis basics and historical development of SWOT along with its merits and limitations.
Psychological and entity factors associated whit corruption
Authors: Valencia Casallas Olga Lucia , Barreto Galeano Maria Idaly
Published: October 2023

Purpose: To identify individual factors affecting entities associated with the occurrence of corrupt conduct. Design/methodology/approach: This is a qualitative study, and information was collected through interviews. It adopted a systematic design, characterized by open, axial, and selective coding. Eleven interviews were conducted with legal professionals specializing in the investigation of financial crimes, who have identified the factors involved in corruption and fraud. The information was analyzed using the ATLAS TI 6.5 software. Findings: The results showed that lack of control was the most important factor that led to corruption in entities, while ambition, greed, and acceptance of corrupt conduct were the most common factors in the individual sphere. Identifying the factors associated with corruption is relevant for proposing preventive measures.
Factors influencing the effectiveness of credit card fraud prevention in Indonesian issuing banks
Authors: Dewi Yuli , Suharman Harry , Sofia Koeswayo Poppy , Dewi Tanzil Nanny
Published: October 2023

The increase in online credit card transactions in the digital era has caused an increase in credit card cyber incidents. This is happening globally, including in Indonesia. Thus, it will affect a bank’s reputation as well as its financial losses. Therefore, optimal fraud risk management is needed in a banking effort to prevent credit card fraud. In response, this article intended to study credit card fraud prevention by examining the relationship between digital security required for customer data security; fraud brainstorming to identify process weaknesses; and compliance management to manage regulatory compliance. The next step was to test whether the anti-fraud specialist is competent to moderate this relationship. This study used a quantitative approach. This study included 27 Indonesian card issuers. Primary sources were used to collect data for this study. The primary data were analyzed using a structural equation model (SEM). The results of the study show that digital security, fraud brainstorming, and compliance management were positively and significantly related to the prevention of credit card fraud, at a significance level of 5%, the t-statistic has a numerical value of 6.161, 5.079, and 5.98 each. Furthermore, testing the moderating effect obtained t-statistic values of 7.330, 4.161, and 7.694. Competency results obtained with positive and significant influence moderate the relationship between these factors and credit card fraud prevention. These findings have policy implications for banking and government objectives in fighting credit card fraud through implementing prevention strategies.
AcknowledgmentsThis research was conducted as part of the process of study completion at the Padjadjaran University, Bandung, Indonesia. We would like to express our sincere gratitude to the respondents who participated in this research.
Problems of Introducing a Differentiated Approach to "Old" and "New" Minorities in Ukraine
Authors: Husiev Oleksii
Published: October 2023

The relevance of the article is due to the reform of the legislative framework on national minorities in Ukraine, which is conditioned by European integration. The purpose of the article is to reveal the problems of identifying persons belonging to "old" minorities in Ukraine and discrimination against "new" minorities. In the course of the research, the author used the dialectical method, logical methods of analysis, synthesis, abstraction, comparative research method, forecasting method, and formal legal method. The author analyzes the provisions of the old inclusive Law of Ukraine "On National Minorities in Ukraine", the new exclusive Law of Ukraine "On National Minorities (Communities) of Ukraine", and some international treaties of Ukraine. The author identifies the problems related to the consolidation of the feature of traditional residence on the territory of Ukraine. The author analyzes the legal status of "new" minorities. It is concluded that the adoption of the new Law of Ukraine "On National Minorities (Communities) of Ukraine" has led to the introduction of a differentiated approach to "old" and "new" minorities in Ukraine, but the shortcomings of this Law make it impossible to determine which national minorities belong to the "old" ones. It is emphasized that the "new" minorities have been discriminated against due to the deprivation of their legal status as national minorities (communities) of Ukraine and equalization with the majority. Recommendations are made to address the identified shortcomings by removing from the concept of "national minority (community) of Ukraine" the feature of traditional residence on the territory of Ukraine and defining precise and clear features of settlements where persons belonging to national minorities (communities) traditionally reside or where they constitute a significant part of the population.
Local Working of Patents: a Comparative Study of Europe and Indonesia
Authors: Dewi Ika , Nu’man Harits , Ruhaeni Neni , Heniarti Dini
Published: October 2023

This study analyzes the implementation mechanism of local working patents from both European and Indonesian perspectives, using normative research methods and secondary data obtained from library research. The implementation of Patent Act Number 13 of 2016 has faced criticism from various parties, including patent holders who find it complicated and difficult to comply with the local working patent provisions. The Ministry of Law and Human Rights has issued regulations to facilitate patent holders who are unable to implement Article 20 by allowing them to request patent postponement. However, the Job Creation Act No. 11 of 2022 has made it easier for patent holders to fulfill their obligations regarding local working patents. The Directorate General of Intellectual Property (DGIP) is responsible for monitoring, evaluating, and reporting on intellectual property protection. However, rules and procedures related to monitoring mechanisms, especially those related to implementing local working patents, have not been fully regulated by the DGIP Office.
«Collaboration», «Collaborationism», «Cooperation», «Collaborative Activity»: Historical and Criminal Legal Dimensions of Terminological Pluralism
Authors: Rubashchenko Mykola
Published: October 2023

The article is devoted to the analysis of historical and law origins of terminological pluralism in the reflection of the cooperation of the population with the occupier. The relevance of the presented material is due to the addition of Article 1111 of the Criminal Code of Ukraine on collaborative activities, the presence of terminological diversity in historical, law, sociological research and legislative work, as well as the ongoing occupation of part of the territories of Ukraine by the Russian Federation.. The aim of the article is to shed light on the genesis of the terminological pluralism that refer to various forms and types of interaction between the population and the occupier (cooperation, collaboration, collaborationism, collaborative activity) and to study the possibility and expediency of their projection on the law dimension. The research strategy involves the use, first of all, of general scientific methods of cognition. The main role in achieving the goal of the article was played by a special historical method and methods of linguistic research. In the process of research, it was established that the main reason for terminological pluralism is the attempt to distinguish different types of interaction with the occupier depending on their ideological and motivational characteristics, circumstances and context of interaction. This, in turn, is connected with the "hellish" complexity of the problem of collaboration with the occupier. It is concluded that the term "collaborative activity" introduced in criminal law is not successful in view of the existing historical approaches and linguistic aspects of borrowing foreign words. The need to consider collaborationism as a generalized concept denoting the natural phenomenon of cooperation with the occupier is substantiated. Determining the breadth of collaborationism is a matter for lawyers. This phenomenon should be considered primarily in the legal sphere. Everything that is beyond legal condemnation cannot be recognized as a component of collaborationism.
The Problem of Balancing the Size of Sanctions in Achieving a Balance of Interests (Using the Example of Customs Duties)
Authors: Kucheriavenko Mykola , Kotenko Artem
Published: October 2023

The relevance of the proposed research, both from theoretical and practical perspectives, lies in addressing the issue of the relationship between the magnitude of sanctions concerning the balance between public and private interests. The main objective of this study is to explore optimal approaches to address issues related to imposing penalties for violations of customs regulations. The results of this research could enhance control procedures and facilitate a balanced determination of penalty sizes in customs law while considering public interest and property rights protection. The study is based on the application of various scientific methods, such as dialectical analysis and synthesis, structural-functional approach, formal-legal and formal-logical analysis, comparative-legal approach, among others. It encompasses an examination of the interplay between public and private interests, as well as an analysis of the system of public interest and potential conflicts arising during the formation of public funds. The research investigates the nature of compulsory payments, such as taxes, fees, and customs duties, illustrated through the example of customs payments. Additionally, it sheds light on issues of administrative liability for customs violations, emphasizing the significance of adhering to specific time criteria when making customs payments and the consequences for the state if these criteria are not met. Furthermore, the study explores the interrelation between material and procedural impact on regulating the behavior of the participants involved in the relationships, emphasizing that these two aspects cannot be separated. It also affirms that the state has the sovereign right to establish taxes, fees, and other payments within its territory to fulfill its functions and meet societal needs. Moreover, the research examines the relationships among various interest groups of participants, such as societal interest, state interest, territorial community interest, government entities, and obligated individuals, while also discerning the division of these interests into disproportionate groups and their interconnectedness. Overall, the research holds significant importance in understanding the issues and prospects within the domain of customs law and administrative responsibility. The findings have the potential to contribute to the improvement of legislation and control procedures, fostering the development of a transparent and efficient legal system capable of safeguarding the interests of all parties involved, including society, the state, and private individuals.
The Effects of Homogeneous Grouping on Gifted Students: A Systematic Literature Review
Authors: Çalışkan Kadir , Tan Sema
Published: October 2023

Introduction: Homogeneous grouping strategies are among the basic interventions for gifted education. Although the academic advantages of these interventions have been frequently documented, concerns about their possible psycho-social negative effects can sometimes lead to cautious approaches to their implementation. In this regard, the main objective of the present study was determined as examining the relationship between homogeneous grouping strategies and the academic and psycho-social characteristics of gifted students.
Method: The current study is a systematic literature review. Empirical resources investigating the effects of grouping strategies implemented in the formal education processes of gifted students were included in the study. Either gifted students of compulsory education age (primary, secondary, and high school) or gifted individuals whose experiences at compulsory education age were focused on were the participants of the included studies. Eighteen studies identified in line with the inclusion criteria were included in the systematic literature review. The effects of homogeneous grouping were examined under the themes of academic effects and psycho-social effects.
Findings: The findings of the systematic literature review demonstrate that implementing homogeneous grouping strategies in gifted education has academically positive but psycho-socially complex (positive and/or negative or neutral) effects.
Discussion: The fact that educational arrangements for characteristics that differentiate gifted students from their peers are associated with positive academic outcomes is consistent with the relevant literature. The psycho-social effects of the homogeneous grouping of gifted students are usually related to self-concept, and most of the research findings included are consistent with the big fish-little pond effect.
Economic, regulatory, policy and carbon-accounting considerations for implementation of CCUS in the Baltic Sea Region
Authors: Honegger Matthias
Published: October 2023

Successful development of CCU and CCS hubs and clusters is as much a technological challenge as it is a non-technical challenge. Non-technical challenges across social and political aspects, economics, monitoring, reporting and verification (MRV), as well as legal, regulatory and contractual aspects all can become showstoppers if they are not given the due careful attention.

Non-technical challenges tend not to predetermine success. Instead, they represent malleable and dynamic factors that evolve over time in response to broader changes in narratives, politics, evolving planning processes, and other regulatory requirements. Attending to non-technical challenges – particularly through proactive measures (e.g. engaging with regulators) requires time, which unless planned for carefully – alongside engineering and business development efforts – may add to the time required for achieving operation through the stages of scoping, planning, and implementation.

The proposed talk will outline some of the most prominently discussed challenges across the various non-technical areas – as identified in the first part of the project CCUS ZEN toward identification of promising CCUS hubs and clusters in selected European regions especially regarding potential challenges in the Baltic Sea region.
Lithuanian renewable energy landscape: CCUS, hydrogen and geothermal
Authors: Karaliūtė Viltė , Makauskas Pijus , Malik Shruti , Kaminskaitė-Baranauskienė Ieva , Pal Mayur
Published: October 2023

Lithuanian energy landscape is changing because of as strong push to reduce carbon emissions and reliance of fossil based energy production. EU climate directive promotes investments into carbon capture and storage technologies along with renewable energy resource development. CCUS, hydrogen and geothermal are some technologies which could promote reduction in carbon emissions and along with reducing dependence on fossil based energy sources. Lithuania already has large potential for carbon and hydrogen storage and in past had a working geothermal power plant for district heating.

In this work we revisit the carbon storage potential in Lithuania subsurface and also provide a high level estimates of potential of generating hydrogen energy from depleted hydrocarbon fields using in-situ methods. We also evaluate the prospects of development of geothermal energy production from deep Cambrian reservoirs where temperature above 85 degrees C have been documented.
Carbon capture and storage (CCS) in the Swedish cement industry – logistics collaboration potentials in the Baltic area
Authors: Santén Vendela , Hedén Anna , Møl Mortensen Gry , Wide Per , Kärnebro Åsa , Kilicaslan Sara , Algell Johan
Published: October 2023

The cement industry in Sweden is facing a major climate change. A central part of the transition is carbon capture and storage (CCS), which is to be implemented in the Swedish largest cement production site on Gotland by 2030. For CCS to be realized, a reliable cost- and environmentally efficient logistics system for CO2 is required, which for the Swedish cement production on Gotland means CO2-transport by ship. A research project has been initiated during 2023 with the aim of increasing the cement industry’s knowledge and understanding of possible CO2 logistics systems for CCS. The project takes a larger innovation system approach of CCS by mapping current knowledge about CO2-logistics for CCS and emerging industrial and logistics actors in the Baltic area and North Sea. Further, logistics scenarios from the perspective of the cement industry will be investigated as well as opportunities for fossil-free CO2-shipping and business models for the cement industry’s CO2-logistics. The Baltic area includes heavy CO2 emitting industries both from cement production as well as steel, pulp & paper, power & heat with locations nearby a port, in which there are several initiatives to apply CCS. Further research will investigate how different types of cross-border collaborations could influence the efficiency of the CO2-logistics system. The project supports the cement industry's decisions regarding processes for the design of CO2-logistics arrangements for CCS.
New production pathway of musty 2,4,6-tribromoanisole during raw water disinfection processes at a surface water treatment plant
Authors: Adams Hunter , Pochiraju Susheera , Ikehata Keisuke , Southard Mark , Reeder Sam , Appleton Emily , Nix Daniel
Published: October 2023

The City of Wichita Falls’ Cypress Environmental Laboratory developed a comprehensive taste and odor (T&O) monitoring program to identify T&O compounds, their point of origin, and how to mitigate each T&O event to lessen its impact and maintain consumer confidence. In January 2023, a T&O compound was detected in the water system using sensory analysis with a threshold odor number (TON) of 3, guiding further analytical testing to identify for musty compounds. The unknown was confirmed to be 2,4,6-tribromoanisole (2,4,6-TBA) at a maximum of 9.86 ng/L. Its point of origin for production was tracked to a raw water line using chlorine dioxide as a primary disinfectant. Jar tests were performed to confirm that the mode of production was excess free chlorine from the generation of chlorine dioxide in the presence of bromide in raw water. The event was mitigated using powdered activated carbon in clarifiers to adsorb and settle out the compound, resulting in a non-detectable level (a TON of 1 and <5.00 ng/L for 2,4,6-TBA). This paper discusses the unique generation pathway within a full-scale treatment plant and how a monitoring and response program can be used to help detect a T&O event in early stages and aid mitigation processes.
Assessment of forest food–water resources nexus and its utilization efficiency based on the Gaussian model
Authors: Xie Weiguang , Ma Huaquan
Published: October 2023

Forest resources are an important foundation for human survival and development, and their utilization and management are of great significance for sustainable development. Forests are important ecosystems that provide essential ecological services for human survival and development. Based on the Gaussian model, this article evaluates the grain and water resources in forest areas to explore the efficiency of forest resource utilization. By collecting and processing sample data from the forest areas of the Yangtze River Basin from October to December 2021, the food and water resources of the forest areas under different vegetation types and soil moisture content were obtained. The results indicate that the total amount of grain resources varies among different sample areas. The maximum weight is 6,000 kg and the minimum weight is 3,500 kg. The total amount of water resources varies among different sample areas, ranging from 600 to 2,000 m3.
A Comprehensive Review on Chemistry and Biology of Tafamidis in
Transthyretin Amyloidosis
Authors: Patil Monali B. , Ghode Piyush , Joshi Prashant
Published: October 2023

Transthyretin amyloid cardiomyopathy and Transthyretin amyloid peripheral neuropathy
are progressive disease conditions caused by Transthyretin amyloidosis (ATTR) fibril infiltration in
the tissue. Transthyretin (TTR) protein misfolding and amyloid fibril deposits are pathological biomarkers
of ATTR-related disorders. There are various treatment strategies targeting different stages
in pathophysiology. One such strategy is TTR tetramer stabilization. Recently, a new TTR tetramer
stabilizer, tafamidis, has been introduced that reduces the protein misfolding and amyloidosis
and, consequently, disease progression in ATTR cardiomyopathy and peripheral neuropathy. This
review will provide a comprehensive overview of the literature on tafamidis discovery, development,
synthetic methods, pharmacokinetics, analytical methods and clinical trials. Overall, 7 synthetic
methods, 5 analytical methods and 23 clinical trials have been summarized from the literature.
Respiratory Viruses Causing Influenza Like Illness/Severe Acute Respiratory
Infection During COVID-19 Pandemic
Authors: Jothisri L. , Das Shukla , Singh Narendra Pal , Saha Rumpa , Raizada Alpana , Ansari Mohammad Ahmad , Jain Charu , Sivakumar  , Dar Sajad Ahmad
Published: October 2023

Background:

Respiratory tract infections caused by viruses are among the most common
diseases in humans worldwide. The diagnosis remains difficult as the symptoms overlap significantly
with each other.

Objectives:

The objective of this study is to identify the respiratory viruses other than SARS-CoV-
-2 causing Influenza-like illness (ILI) /severe acute respiratory infection (SARI) during
COVID-19 pandemic

Methods:

A total of 100 samples, including COVID-19 positive (n=50) and negative (n=50), were
included in the study. The detailed case record form was filled for each patient including relevant
history. Nasopharyngeal and Oropharyngeal swabs were subjected to standardized RT-PCR for
the detection of SARS-CoV-2 followed by Multiplex RT-PCR for other respiratory viruses.

Results:

Other respiratory viruses causing ILI/SARI symptoms similar to SARS-CoV2 during
COVID-19 pandemic in non-COVID-19 patients aged more than 18 years were found to be Human
metapneumovirus (2%), Human adenovirus (1%), Human parainfluenza virus-1 (1%). The result
suggested that other respiratory viral infections are significantly higher among COVID-19
negative individuals presenting with respiratory illness as compared to COVID-19 positive individuals,
possibly due to viral interference and competitive advantage of SARS-CoV-2 in modulating
the host immune system.

Conclusion:

The other respiratory viruses in SARS-CoV-2 negative patients had mild to moderate
ILI/SARI symptoms, which usually do not require hospitalization but need to be monitored, especially
in high-risk patients. Human metapneumovirus, Adenovirus, Parainfluenza virus-1 most
commonly occured in more than 60 years age group with comorbidity which can be useful in stratification
for future surveillance of other respiratory viruses in health care settings.
Application Research and Prospect of 3D Modeling, Printing Medical
Course Teaching Aids
Authors: Ren Bin , Wang Han , Zhang Ting
Published: October 2023

Background:

The application of 3D printing technology in the field of education is
mainly concentrated on the curriculum of primary and secondary schools and clinical PBL
teaching, while the application of 3D printing technology as a teaching auxiliary means in
higher medical education is less.

Methods:

The objective of this work is to demonstrate the use of 3D printing teaching aids to
improve students' learning outcomes and guide more students to participate in learning 3D
printing or biological 3D printing research.
Based on 3D printing technology, data were collected through a network questionnaire to analyze
the demand of medical students in Colleges and Universities in this paper for 3D printing
teaching aids. Through the demand for 3D printing teaching aids, we have offered 3D courses
and encouraged students to actively participate in model design.

Results:

Students can print some models using a 3D printer based on their knowledge and
personal interests. It is found that universities can use virtual 3D printing technology to make
up for the current shortage of 3D printers and high material consumption.

Conclusion:

3D printing technology can also help biomedical engineering students better
combine clinical knowledge to achieve better results. In addition, this study also analyzed the
limitations of 3D printing development in China.
Effect Produced by the Treatment Type on the Performance of the
Artificial Heart Valve Welded Frame
Authors: Pachurin German Vasilevich , Kuzmin Nikolay Aleksandrovich , Mochalina Maria Vadimovna , Filippov Alexey Aleksandrovich
Published: October 2023

Background:

The welded joint loss of performance is largely determined by the
heterogeneity of the structural state of the heat-affected zones. The basic materials from
which the artificial heart valve welded frames are made are technically pure titanium grade
VT1-OS and alloy grade 40 KHNM with the required biomedical properties.

Objective:

The study of the structural state, and changes in mechanical characteristics under
static and cyclic loading of welded joints made of pure titanium grade VT1-OS and alloy
grade 40 KHNM.

Method:

The paper investigates structural changes and mechanical characteristics under static
and cyclic loading in Ringer-Locke saline solution of welded T-shaped joints made of pure
titanium grade VT1-OS and alloy grade 40 KHNM, simulating the nodes of an artificial heart
valve subject to maximum cyclic loads during operation.

Result:

It is revealed that the structural and mechanical heterogeneity along the length of the
welded joints of the studied materials determines a loss of mechanical performance, both under
static and cyclic loading.

Conclusion:

Experimental batches of welded elements of artificial heart valve assemblies
made of VT1-OS titanium and 40 KHNM alloy according to the established optimal modes
have successfully passed full-scale tests on physiological and biological stands in conditions
as close as possible to the operational ones.
Tungstophosphate Intercalated ZnAl Layered Double Hydroxide for Adsorptive and Visible Light Driven Photocatalytic Decolourisation of Organic Dyes
Authors: Mohanta Bhabani Shankar , Das Rita , Das Nigamananda
Published: October 2023

Tungstophosphate (PW12O403-) intercalated ZnAl-Layered double hydroxide (ZnAl-PW12) was successfully synthesized through the rehydration of calcined LDH. Chemical analyses and characterizations by powder XRD, FT-IR, and Diffuse reflectance UV-Vis spectra confirmed the intercalation of PW12O403- ions equivalent to ~80% of the residual positive charge in the brucite layer. The efficiency of ZnAl-PW12 for decolourisation of four structurally different cationic/anionic dyes through simultaneous adsorption and photocatalysis under visible light irradiation was assessed. Under identical conditions, the photocatalytic efficiency of the ZnAl-PW12 catalyst was found to be much higher than that of calcined ZnAl-LDH, indicating the promoting effect of PW12O403- ion. Moreover, the loss of costly polyoxometallate (POM) could be avoided by intercalating the POM ion in the interlayer of LDH, which can facilitate the use of synthesized catalysts for repeated cycles.
Coping with Burnout in the Healthcare Field
Authors: Rokach Ami , Patel karishma
Published: October 2023

The healthcare industry is the largest and fastest growing industry in the world; however, being a part of the healthcare system involves being at an increased risk of experiencing mental health problems, loneliness, stress, and increased susceptibility to experiencing compassion fatigue related to the emotional wear associated with providing patient-centered care. Healthcare workers include, but are not limited, to physicians, nurses, allied health professionals, and psychologists. Often, healthcare workers place the needs and wellbeing of patients before their own. This article aims to highlight the occupational hazards of working in the healthcare field, the physical and emotional isolation associated with clinical practice, managing distressing behaviors by patients, and reviewing the systemic barriers influencing the development and management of moral distress. We further aim to bring attention to the need for healthcare professionals to place self-care at the forefront of their therapeutic repertoire through various individualized strategies, through the importance of building moral resilience, and the shift towards improving workplace spirituality. Practicing self-care can address the consequences of neglecting one’s own wellbeing, positively impact the ability to provide better quality patient care, and benefits relationships with patients, loved ones, and of most importantly with oneself.
Effects of Digital Health Technology Literacy, Health Empowerment, and Self-Efficacy on Health-Promoting Behavior Among Adults in Korea (Preprint)
Authors: Kim Hyejin , Kim Ji-Su , Shin Hyerine , Chung Yoongi
Published: October 2023

BACKGROUND

The number of Internet users searching for and utilizing health and other information is constantly increasing worldwide. The ability to seek, navigate, understand, and evaluate health information and services on the Internet that are necessary to recognize one's health problems and make sound health-related decisions, as well as the ability to apply and communicate the knowledge gained to address and solve health problems, is referred to as eHealth literacy. However, previous studies on eHealth literacy are mainly based on eHealth services and limited to areas that utilize digital technologies, such as social media, mobile health, artificial intelligence, and wearable devices. However, health literacy should be reevaluated to facilitate seeking health information and utilizing digital technology to address and solve health problems in line with the rapidly progressing Fourth Industrial Revolution era. The effect of digital health literacy on health-promoting behavior should be examined using a conceptually developed tool. Digital health literacy and the ability to utilize digital technologies have received increasing attention during the COVID-19 pandemic. In addition, previous studies have emphasized health empowerment and self-efficacy as factors significantly influencing health behaviors and outcomes.

OBJECTIVE

This study aimed to examine the relationships among digital health technology literacy, health empowerment, self-efficacy, and health-promoting behavior and identify the factors that influence health-promoting behavior in adults.

METHODS

The participants were 1086 adults who completed an online self-reported questionnaire survey. Descriptive statistics, t-tests, analysis of variance with Scheffe's test, Pearson correlation coefficient, and multiple regression were performed using SPSS 25.0.

RESULTS

The results revealed that age, economic status, religion, smoking, health empowerment, and self-efficacy affected health-promoting behavior, with an explanatory power of 35.6%. However, digital health technology literacy did not influence health-promoting behavior. Higher health empowerment (p<.001) and self-efficacy (p<.001) were associated with higher health-promoting behavior. Moreover, high economic status had the greatest influence on health-promoting behavior (beta=5.339).

CONCLUSIONS

This study demonstrated that strengthening health empowerment and self-efficacy improved health-promoting behavior among adults, and that factors affecting health-promoting behavior did not differ significantly among the general adult population, individuals with specific diseases, and individuals in specific classes. Digital health technology literacy was likely not an influential factor because this study used an online survey.
Data Visualization Support for Tumor Boards and Clinical Oncology: Protocol for a Scoping Review (Preprint)
Authors: Boehm Dominik , Strantz Cosima , Christoph Jan , Busch Hauke , Ganslandt Thomas , Unberath Philipp
Published: October 2023

BACKGROUND

Complex and expanding data sets in clinical oncology applications require flexible and interactive visualization of patient data to provide the maximum amount of information to physicians and other medical practitioners. Interdisciplinary tumor conferences in particular profit from customized tools to integrate, link, and visualize relevant data from all professions involved.

OBJECTIVE

The scoping review proposed in this protocol aims to identify and present currently available data visualization tools for tumor boards and related areas. The objective of the review will be to provide not only an overview of digital tools currently used in tumor board settings, but also the data included, the respective visualization solutions, and their integration into hospital processes.

METHODS

The planned scoping review process is based on the Arksey and O’Malley scoping study framework. The following electronic databases will be searched for articles published in English: PubMed, Web of Knowledge, and SCOPUS. Eligible articles will first undergo a deduplication step, followed by the screening of titles and abstracts. Second, a full-text screening will be used to reach the final decision about article selection. At least 2 reviewers will independently screen titles, abstracts, and full-text reports. Conflicting inclusion decisions will be resolved by a third reviewer. The remaining literature will be analyzed using a data extraction template proposed in this protocol. The template includes a variety of meta information as well as specific questions aiming to answer the research question: “What are the key features of data visualization solutions used in molecular and organ tumor boards, and how are these elements integrated and used within the clinical setting?” The findings will be compiled, charted, and presented as specified in the scoping study framework. Data for included tools may be supplemented with additional manual literature searches. The entire review process will be documented in alignment with the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) flowchart.

RESULTS

The results of this scoping review will be reported per the expanded PRISMA-ScR guidelines. A preliminary search using PubMed, Web of Knowledge, and Scopus resulted in 1320 articles after deduplication that will be included in the further review process. We expect the results to be published during the second quarter of 2024.

CONCLUSIONS

Visualization is a key process in leveraging a data set’s potentially available information and enabling its use in an interdisciplinary setting. The scoping review described in this protocol aims to present the status quo of visualization solutions for tumor board and clinical oncology applications and their integration into hospital processes.

CLINICALTRIAL

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/53627
Visualização molecular interativa para situações de estudo
Authors: Ribeiro Pereira Andressa , Queiroz Ferreira Alba Denise
Published: October 2023

A química estrutural pode ser discutida com substâncias aromáticas, aplicando os recursos digitais PUBCHEM, o banco de dados de espectros de RMN-1H e IV – SDBS, o simulador de espectros de RMN-1H, NMRDB, para a elaboração de atividades interativas que promovam a visualização molecular em situações de estudo (SE). Foram selecionadas cinco substâncias, sendo que quatro delas formam dois pares de isômeros estruturais, um par com a composição C5H10O2 com grupos funcionais distintos, o formato de isobutila – aroma da amora e o etanoato de butila – aroma da maçã; o segundo par tem a fórmula química C9H10O2, acetato de benzila – aroma da pera e fenilacetato de metila – aroma de mel, tendo as duas moléculas grupos funcionais idênticos.  A análise preliminar dos espectros de RMN-1H foi exemplificada com a comparação dos valores de deslocamento químico, intensidade dos sinais e os seus desdobramentos. A introdução da técnica de RMN-1H no ensino médio e na formação de professores é sugerida, pois demonstra como a química é praticada, pode contribuir com a alfabetização científica em uma SE e para desenvolver as competências da BNCC: “exercitar a curiosidade intelectual e recorrer à abordagem própria das ciências” e “argumentar com base em fatos, dados e informações confiáveis”.
Perpetração de bullying e depressão em crianças e adolescentes: uma revisão de escopo
Authors: De Araújo Gleyde Raiane , Rodrigues da Costa Wesley , De Assis Freire Sandra Elisa , Negreiros Fauston , Medeiros Emerson Diógenes
Published: October 2023

O presente estudo consiste em uma revisão de escopo em consonância com o protocolo de Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). Assim, a pesquisa objetivou conhecer a relação entre perpetração de bullying e depressão em crianças e adolescentes no contexto escolar. As pesquisas foram realizadas nas bases PsycInfo, Medline, PsycArticles e Scopus, com o recorte temporal dos últimos 5 anos. Ao todo foram encontradas 315 publicações e após triagem 26 foram incluídas. Dentre os resultados, identificou-se a relação preditora bidirecional e correlacional entre perpetração e depressão. Além disso, outras variáveis intra e interindividuais parecem estar relacionadas a esse contexto. Indica-se que intervenções antibullying para perpetradores incluam estratégias para identificação e mitigação de sofrimento psicológico, especificamente a depressão.