bluuebunny/crossref_metadata_2025 huggingface dataset:
Oral Antiviral Treatment for COVID-19 in Patients With Systemic Autoimmune Rheumatic Diseases
Authors: Gerolymatou Nafsika , Bakasis Athanasios-Dimitrios , Voulgari Paraskevi V. , Vlachoyiannopoulos Panayiotis G.
Published: December 2022

Objective

To describe data on the safety and efficacy of molnupiravir (MP) and nirmatrelvir/ritonavir (NM/R) in patients with systemic autoimmune rheumatic diseases (SARDs).

Methods

Among patients with SARD being followed in 2 tertiary outpatient rheumatology clinics, we retrospectively identified those infected with SARS-CoV-2 between February and August 2022 who received MP or NM/R. Patients’ medical files were reviewed for demographics and disease-related characteristics, as well as coronavirus disease (COVID-19) characteristics, including vaccination status, antiviral treatment, side effects, and COVID-19 outcomes.

Results

Seventy-four patients with SARD (52 females) were identified who had been infected with SARS-CoV-2 and received MP (n = 26, 35.1%) or NM/R (n = 48, 64.9%). Most patients were vaccinated against SARS-CoV-2 (n = 62, 83.8%). Among frequently used regimens were glucocorticoids (n = 43, 58.1%), mycophenolate mofetil (n = 26, 35.1%), tumor necrosis factor inhibitors (n = 14, 18.9%), methotrexate (n = 13, 17.6%), and rituximab (n = 12, 16.2%). Common adverse events were reported only by 4 patients receiving NM/R (metallic taste, gastrointestinal upset, hypertension), not leading to drug discontinuation. During follow-up, all but 2 patients (n = 72, 97.3%) recovered at home without COVID-19–related complications. Nonetheless, we describe 2 presumptive cases of COVID-19 rebound who progressed to severe COVID-19.

Conclusion

These data show a favorable outcome and acceptable safety profile of the 2 oral antiviral therapies MP and NM/R among a high-risk SARD population. However, cases of COVID-19 rebound are being increasingly identified. These findings call for continuous surveillance to capture the real-world efficacy and safety profiles in our subpopulations of interest.
Accompagner au-delà des 21 ans
Authors: Rodriguez Vincente
Published: December 2022

Le parcours social, entre protection et contractualisation, est historiquement lié à la société dans laquelle il intervient. Sa vocation à réduire les inégalités ou inadaptations lui confie une place importante pour donner sens dans un contexte de crise et de mutation de la société. Cette évolution sociétale, associée à une institutionnalisation du secteur de la protection de l’enfance et à de nouvelles pratiques professionnelles (logique de parcours, développement du numérique, participation des personnes accompagnées, etc.), bouleverse le quotidien des acteurs du monde social et du public. Un public qui tente de se reconstruire par suite d’un parcours de vie ébranlé par une pluralité d’événements, avec l’espoir de croire à la réussite et de devenir un homme qui participe à bâtir le monde.
Deux DEISsiennes à la recherche de la reconnaissance perdue
Authors: Andriet Vanessa , Grayon Anouk
Published: December 2022

En quoi la reconnaissance, tout particulièrement au travail, est-elle indispensable à l’individu et à la société, et in fine impacte la cohésion sociale ? C’est ce que questionnent deux quadragénaires DEISsiennes, en initiant une démarche en cohérence avec leur identité professionnelle : prendre appui sur la méthodologie de la déambulation pour partager les constats issus de leur pratique du travail social, faire le pari que cette expérimentation à une microéchelle peut être porteuse de sens.
L’approche centrée sur l’expérience de la personne en tant qu’utilisatrice ( UX Design ). Une perspective d’avenir pour le Travail social
Authors: Félix Aline , Kempter Kevin , Descloux Romain
Published: December 2022

La conjoncture actuelle modifie la structure de la société et remet en cause les services à la personne. Les impacts dans le champ du Travail social sont nombreux. Cet article propose un regard critique sur les lacunes des pratiques traditionnelles de ce champ professionnel à l’aune de certains enjeux qui le traverse. Pour répondre à ces multiples défis, les auteurs proposent une discussion sur les méthodes de l’ UX design (centrées sur la personne en tant qu’utilisatrice) comme solution pour pallier les besoins émergents et l’apparition de nouveaux publics. Axées sur le paradigme de l’innovation sociale, ces méthodes agencent des savoirs diversifiés pour repenser les dispositifs et les interventions.
Comme un océan…
Authors: Indirli Vincent
Published: December 2022

Ne serait-ce pas leur place que d’être là aussi pour ceux qui, faible ou fort, vulnérable ou dur, vieux ou jeune, moche ou beau, au terme de leur périple océanique, après avoir été jusqu’au bout de ce que la barque de leur corps, les voiles de leur cœur leur auront permis de vivre, demanderont à pouvoir trouver l’apaisement de la profondeur de l’océan ?
Status quo and loss aversion: Are people less conservative to avoid a loss?
Authors: El Harbi Sana , Toumia Oumeima
Published: December 2022

Une littérature de plus en plus abondante fait état de l’impact du biais de statu quo dans les décisions réelles. Cependant les études antérieures ne fournissent pas de preuves directes de l’effet du SQ en considérant la distinction entre le cadre de gain et le cadre de perte. Ainsi cherchons-nous à déterminer si l’étendue du choix du statu quo dépend de l’effet de cadrage. Nous utilisons une expérience de conception inter-sujets basée sur des choix de loterie dans un cadrage de gain versus un cadrage de perte. Nos résultats concordent avec l’observation selon laquelle, dans le domaine des pertes, les individus ont plus tendance à chercher les risques. Notre article présente les implications pour la recherche et la pratique. En particulier l’examen du biais de statu quo, de l’effet de cadrage (gain-perte) et de l’interaction entre les deux, contribue à la littérature sur la gestion et l’organisation. Néanmoins, des sommes d’argent plus importantes, plus de choix et plus de tranches d’âges peuvent être utilisés pour étudier la robustesse de nos résultats.
Persistence of the heteroclinic loop under periodic perturbation
Authors: Long Bin , Xu Shanshan
Published: December 2022

We consider an autonomous ordinary differential equation that admits a heteroclinic loop. The unperturbed heteroclinic loop consists of two degenerate heteroclinic orbits $ \gamma_1 $ and $ \gamma_2 $. We assume the variational equation along the degenerate heteroclinic orbit $ \gamma_i $ has $ {d_i}\left({{d_i} > 1, i = 1, 2} \right) $ linearly independent bounded solutions. Moreover, the splitting indices of the unperturbed heteroclinic orbits are $ s $ and $ -s $ $ (s\geq 0) $, respectively. In this paper, we study the persistence of the heteroclinic loop under periodic perturbation. Using the method of Lyapunov-Schmidt reduction and exponential dichotomies, we obtained the bifurcation function, which is defined from $ \mathbb{R}^{d_1+d_2+2} $ to $ \mathbb{R}^{d_1+d_2} $. Under some conditions, the perturbed system can have a heteroclinic loop near the unperturbed heteroclinic loop.
La régulation des activités scolaires numériques des élèves par l’enseignant : le cas d’une application d’apprentissage adaptatif
Authors: Cerisier Jean-François , Pierrot Laëtitia
Published: December 2022

L’article traite de la régulation par l’enseignant de l’activité d’élèves qui utilisent des ressources numériques mobilisant des techniques d’apprentissage adaptatif (adaptive learning). La recherche présentée est exploratoire. Elle a été réalisée en marge d’une collaboration avec l’entreprise EvidenceB pour améliorer l’expérience utilisateur d’une application intégrant un agent conversationnel pour les apprentissages fondamentaux du français au lycée. Elle vise notamment à établir une première caractérisation des contraintes spécifiquement induites par les techniques d’intelligence artificielle (IA) susceptibles d’entraver l’appropriation de l’application par les enseignants afin de structurer de nouveaux travaux de recherche. L’analyse thématique d’une série d’entretiens révèle un paradoxe, celui d’un enseignant qui n’a jamais été autant informé du parcours d’apprentissage de chaque élève, mais dont le pouvoir de pilotage pédagogique et didactique est partiellement délégué à la machine. Pour autant, nous considérons que ce paradoxe n’est qu’apparent. Si l’IA permet une automatisation partielle de la régulation pédagogique exprimée en termes de prescription et de suivi des activités, elle donne aussi aux enseignants les moyens d’une régulation plus personnalisée en ce qui concerne l’accompagnement des élèves. L’effet de désintermédiation redouté par certains, celui de la substitution de l’enseignant par une « machine à enseigner » apparaît bien comme un risque potentiel, mais limité à des micro-situations et son actualisation dépend fortement de la capacité de l’enseignant à intégrer les apports de l’IA à son ingénierie pédagogique. Finalement, la question de l’utilisation de ces techniques s’apparente aux problématiques d’hybridation de la formation et invite à penser et concevoir l’hybridation homme-machine des processus de régulation des activités d’apprentissage des élèves.
Electrochemical Studies on Poly(Ethylene Oxide) Based Gel-Polymer Electrolytes for Magnesium-Ion Batteries
Authors: Jathushan V. , Jayamaha J.H.T. Bandara , Wijayasinghe H.W.M.A.C. , Vignarooban K.
Published: December 2022

Research and development works in the field of multi-valent metal-ion batteries are intensified these days because of the abundance of multi-valent elements such as magnesium, aluminum, calcium and so on in the Earth’s crust. Magnesium-ion batteries are particularly important, because they have high theoretical volumetric capacity (3832 mAh cm-3) compared to that of well-known lithium-ion batteries (2062 mAh cm-3). However, there are potential challenges, typically, designing suitable electrolytes with sufficient ambient temperature ionic conductivities is a major challenge. In this work, a set of gel-polymer electrolytes based on poly (ethylene oxide) (PEO) host polymer and magnesium acetate (Mg(CH3COO)2) ionic salt have been synthesized and characterized by electrochemical impedance spectroscopy (EIS), DC polarization and linear sweep voltammetry (LSV) techniques. Among the compositions studied in this work, the optimized PEO-Mg(CH3COO)2-EC-PC electrolyte (6:14:40:40 wt.%) showed an ambient temperature ionic conductivity of 6.1x10-5 S cm-1. Ionic conductivity vs inverse temperature showed Arrhenius behavior with almost same activation energies (0.15 - 0.18 eV) for all the compositions. DC polarization studies performed with stainless steel blocking electrodes under an externally applied voltage of 1V showed that the highest conducting composition is dominantly an ionic conductor with an ionic transference number of 0.99. The electronic contribution to conductivity was found to be almost negligible, which is desirable to avoid short circuits within the cell. The LSV test on highest conducting composition revealed that the electrochemical stability window of these electrolytes is about 2.2 volts.
Molecular Interaction of Angiotensin-I Converting Enzyme (ACE) with Peptides Derived from Collagen Type i as Analogue for Tilapia By-Product Protein Precursor
Authors: Abd Wahab Nur Suraya , Anak Yaji Emmy Liza , Abd Talib Norfahana , Sabri Mohamad Zulkeflee , Yong Kelly Tau Len , Razali Nadia , Pa'ee Khairul Faizal
Published: December 2022

The study aimed to investigate the molecular interaction of ACE-inhibitory peptides derived from collagen type I. Collagen type I alpha 1 and alpha 2 were used in this work was to analogue the tilapia by-product protein precursor for ACE-inhibitory peptides production. In silico production of ACE-inhibitory peptides derived collagen type I from BIOPEP was used to simulate peptide-ACE interaction using Autodock Vina. Most potent ACE-inhibitory tri-and di-peptides, Gly-Leu-Pro (GLP IC50 1.62 μM) and Cys-Phe (CF IC50 1.96 μM) derived alpha 1 and Leu-Gly-Pro (LGP IC50 0.72 μM), and Glu-Tyr (EY IC50 2.68 μM) derived alpha 2 were chosen from BIOPEP database. The hydrophobicity of the amino acids is suggested to contribute to bioactivity. These peptides inhibited the active sites of ACE at the C terminal residue. The zinc (II) interacted with all four peptides directly and indirectly. GLP and CY of alpha 1 could share a bond with His 383, His 387, and Glu 411 instead of directly binding to the zinc (II) atom. ACE has a zinc ion in its coordinates with His 383, His 387, and Glu 411. Alpha 2's LGP and EY were directly bound to Zinc (ii) atoms.
Gender Stereotypes Changes and Changing Gender Role Behaviors: A Theoretical Perspective
Authors: Priyashantha K. G. , De Alwis A. C. , Welmilla I.
Published: December 2022

Many scholars have used social role theory to examine gender stereotypes and changes in gender stereotypes. However, it falls short of having the same explanatory power as persons who engage in gradual cognitive processes that alter gender stereotypes and gender role behaviors. In this perspective paper, we argue that the theory of planned behavior can be used to explain the step-by-step cognitive processes of changing gender stereotypes and changing gender role behaviors. It can further be used to examine whether gender stereotypes have changed. The context we selected for this task is. We used two perspectives in this task and examined Sri Lanka as the context for analysis. In the first perspective, we argue that Attitudes, Subjective Norms, and Perceived Behavioral Control influence the Intentions for Changing Gender Role Behaviors. In the second perspective, we argue that Intentions and Facilitative Conditions for Changing Gender Role Behaviors influence the Changing Gender Role Behaviors. Moreover, each perspective provides directions for future research and implications for the theory.
Passero Passer italiae x hispaniolensis nidificante su barca da pesca in Sicilia
Authors: Surdo Salvatore
Published: December 2022

Si segnala la nidificazione di passera sarda Passer prope hispaniolensis su delle barche da pesca (gozzi) ormeggiate a Margi Spanò (Trapani). Sebbene la nidificazione di uccelli su imbarcazioni sia stata documentata, la maggioranza dei casi è riferita a specie acquatiche quasi esclusivamente appartenenti alle famiglie Anatidae, Rallidae e Sulidae. Di particolare interesse è il fatto che almeno 12 coppie hanno utilizzato come sito di nidificazione cinque diversi gozzi ormeggiati.
Atlanti ornitologici, tra successi e fatiche di Sisifo
Authors: Ferlini Flavio
Published: December 2022

Gli atlanti ornitologici sono strumenti importanti sia per acquisire informazioni preziose sulla qualità ambientale, sia per una corretta pianificazione del territorio. Di particolare rilevanza sono poi le indicazioni dei cambiamenti nelle distribuzioni che possono emergere da indagini condotte sullo stesso territorio a distanza di tempo. Prendendo spunto dalla pubblicazione a partire dal 2020 del secondo Atlante degli uccelli nidificanti in Europa (EBBA2) e di alcuni altre analoghe indagini sia a scala nazionale sia regionale, viene brevemente ricordata la storia di questa tipologia di opere e confrontata la situazione italiana con quella di altre nazioni sia europee che extra-europee. Per superare le difficoltà rilevate nel pubblicare i risultati del primo atlante degli uccelli svernanti in Italia, una possibile soluzione è l’adozione del modello semplificato già utilizzato dal Giappone in aderenza ai principi minimalisti della Shibusa.
Nebulized Mycobacterium vaccae protects against asthma by attenuating the imbalance of IRF4/IRF8 expression in dendritic cells
Authors: Sun Qi-Xiang , Xu Si-Yue , Li Lao-Dong , Xiao Huan , Zhang Qian-Nan , Li Chao-Qian
Published: December 2022

Objective:

To assess the effects of nebulized inhaled Mycobacterium vaccae on allergic airway inflammation, airway hyperresponsiveness, and Th1/Th2 cell imbalance in mice with ovalbumin (OVA)-induced asthma.

Methods:

Mice received OVA sensitization and challenge for establishment of the asthmatic model. For intervention, mice received Mycobacterium vaccae nebulization once every other day from the first day of sensitization to the day before challenge. After challenge, pulmonary histological analysis and airway responsiveness measurement were performed. In addition, Th1/Th2 cytokines and OVA-specific IgE levels in bronchoalveolar lavage fluid were measured by ELISA. Th1/Th2 subset ratios and the expression of interferon-regulatory factor 4 (IRF4), IRF8 and Toll-like receptor 4 (TLR4) in dendritic cells were evaluated by flow cytometry.

Results:

Severe inflammatory infiltration and airway hyperresponsiveness were observed in OVA-induced asthmatic mice. Asthmatic mice showed higher Th2 cytokine concentration and increased percentage of Th2 cells, along with lower Th1 cytokine concentration and reduced percentage of Th1 cells compared with the normal control. Moreover, an imbalance of IRF4+ and IRF8+ in dendritic cells was found in asthmatic mice. Nebulized inhaled Mycobacterium vaccae reduced airway hyperresponsiveness and inflammation in OVA-induced asthmatic mice. In addition, nebulized inhaled Mycobacterium vaccae enhanced TLR4 and IRF8 expression, and alleviated the imbalance of Th1/Th2 as well as IRF4+ and IRF8+ in dendritic cells.

Conclusions:

Nebulized inhaled Mycobacterium vaccae protects against asthma by alleviating the imbalance of Th1/Th2 and IRF4/ IRF8 in OVA-induced asthmatic mice.
An Audit of Cancellation of Elective Surgery in Paediatric Patients at Chris Hani Baragwanath Academic Hospital
Authors: Gamede Nomdumiso , Campbell Ryan , Mogane Palesa
Published: December 2022

Background:

Cancellation of elective surgery is one of the quality indicators of theatre operation worldwide. The cancellation of elective surgery in paediatric patients is a worldwide problem with the rates ranging from 0.21% to 44%. This study aimed to determine the rates and describe the reasons for cancellation of elective surgeries in paediatric patients at Chris Hani Baragwanath Academic Hospital (CHBAH).

Materials and Methods:

A retrospective study was conducted using theatre records from 1st January to 31st December 2019. The numbers and reasons for elective paediatric surgeries were reviewed. Data were collected using the structured collection sheet and entered into Microsoft Excel. Statistical Package for the Social Sciences was also used to further analyse the data. Results were expressed as percentages in a graph and table forms.

Results:

In the year 2019, a total of 3399 elective paediatric procedures were scheduled in 14 specialities at CHBAH. Of these, 634 (19%) were cancelled due to various reasons. The highest number of cases cancelled were from paediatric surgery and neonates (n = 204, 31%), followed by ear nose and throat (n = 99, 24%), burns (n = 80, 20%) and paediatric orthopaedics (n = 79, 16%). The most common reason for cancellation of elective surgery in paediatric patients at CHBAH was found to be time constraint (34%). The reasons for cancellation in our study were mostly due to avoidable factors at 68% and non-avoidable at 32%.

Conclusion:

The rate of cancellation in our study was high. Majority of the causes for cancellation were avoidable.
Is it Reliable to Make a Decision Based on Visual Changes in the Patient's Diaper in the Evaluation of Post Circumcision Bleeding?
Authors: Akman Mustafa
Published: December 2022

Background:

The most common complication of circumcision is bleeding. Monitoring bleeding by visual assessment of the diaper can cause errors due to the high absorbency of diapers. The patient may have had significant problems before the visible changes. The amount of liquid that wets the cloth does not necessarily lead to a visual change consistent with the amount, and the nature of the liquid contaminating the diaper may cause difficulties in terms of visual evaluation. Making a decision based on the visual changes in the patient's diaper cannot be considered as reliable.

Methods:

We planned to evaluate the visual changes that are caused by liquids of various volumes and contents that wet the diaper, according to measurable criteria. We aimed to emphasise the importance of the subject in circumcision practices of diapered children. Wetting of diapers with different volumes and variable blood load was performed utilising blood with different haematocrits and fluids. One hundred and sixty different diapers in four groups were moistened utilising the drip method. Visual changes in the soaked diapers were evaluated with the colorimetric method and five different colour criteria. The saturation and lightness values, which indicate the colour value, were obtained by using the numerical equivalents of the three main components, red, green and blue. Analysis was carried out by subjecting statistical evaluation within and between groups.

Results:

There was a significant difference between the control group and the study group. It was observed that visual changes caused by the moistened cloths with linear increase did not make the same linear interaction. There was not a significant difference between Group II and Group IV, which were soaked with the same amount of blood and different volume of fluid. In Group III, colour saturation changes were found to have a parabolic effect instead of a linear change. In two different analyses of moistened diapers in terms of volume and blood load; it was not determined that the expected linear changes between the groups were not observed.

Conclusion:

Visual changes in diapers related to volume or blood load effects of fluids may not be compatible with the amount of bleeding. Mistakes may occur when super absorbent wipes are used when determining the amount of bleeding from the use of colour changes in the diaper. Visual changes should not be relied on in bleeding due to circumcision. Rather, vital signs follow-up and measurable laboratory tests should be used as a basis.
Bezoar Types in Children and Aetiological Factors Affecting Bezoar Formation
Authors: Dorterler Mustafa Erman , Günendi Tansel , Çakmak Mehmet , Shermatova Saime
Published: December 2022

Background:

Bezoar is formed as a result of the accumulation of undigested food or foreign substances in the gastrointestinal tract (GIS). The present study aims to investigate the bezoar types seen in children and the aetiological factors involved in bezoar formation.

Methods:

A total of 16 patients who underwent an endoscopy and/or surgical treatment for bezoar at Harran University, Faculty of Medicine Pediatric Surgery Clinic between 2011 and 2019 were included in the study. The demographic information, laboratory and radiological findings were obtained from the patients' file records.

Results:

A total of ten patients (62.5%) were female with a mean age of 7.8 ± 4.9 years. Phytobezoars were detected in ten patients, trichobezoars in two patients, lactobezoar in one patient, and other types in three patients. The aetiological factors were determined to be congenital GIS anomaly in 6 (37.5%) patients; trichotillomania in 2 (12.5%) patients; mental retardation in 2 (12.5%) patients; ingestion of a foreign body during infancy in 2 (12.5%) patients; high intake of high-fibre fruit in 3 (18.5%) patients; and postoperative dysmotility in 2 (12.5%) patients.

Conclusions:

Congenital GIS anomalies are mostly responsible for bezoar etiology in children and phytobezoar is the most common type of bezoar.
A Short-Term Study of Clinical and Radiological Outcomes of Total Knee Replacement Using All Polyethylene Tibial Component
Authors: Jaiswal Sankalpa , Pandey Sarvesh Kumar , Yadav Ajay Kumar , Khare Rahul , Singh Devender
Published: December 2022

Osteoarthritis (OA) of bone peripherally is frequently associated with pain, physical disability and worsening quality of life, which in turn leads to a considerable burden on the society and individuals. The surgical management of OA comprises of arthroscopy, high tibial osteotomy (HTO), unicompartmental knee arthroplasty and total knee arthroplasty (TKA). High tibial osteotomy and unicompartmental knee arthroplasty are potential alternatives if only a single compartment is involved with more data supporting unicompartmental knee arthroplasty as a good treatment option in this scenario. To conclude, early tibial component designs were almost uniformly all polyethylene and still continue to dominate the market. The total condylar designs using these tibial components have continued to show greater than 90% survivorship. No statistically significant improvement was seen in the radiological outcomes in patients undergoing All-Polyethylene tibial component at short term follow up. In this study, there was a significant improvement in the Knee society score, WOMAC score and Oxford score post operatively.
Giant Cell Tumor of Distal end Radius Managed by En Bloc Resection with Wrist Arthrodesis using Fibula Bone
Authors: Kumar Ashutosh , Mittal Saurabh , Bamania Narendra H , Singh Bhawna , Somashekarappa T
Published: December 2022

Introduction:

Giant cell tumor is a benign but locally aggressive tumor typically found in the epiphysis of long bones. Patients are usually females typically presenting between ages 30 and 50. Confirm diagnosis is based on biopsy. Treatment includes radiation therapy, bisphosphonates, denosumab, extensive curettage with adjuvant treatment, and reconstruction. We managed our case by en bloc resection of the tumor with wrist arthrodesis with fibula bone.

Result:

The patient had a good functional grip with 80° of pronation and 60° of supination.

Conclusion:

Resection of the tumor along with ipsilateral nonvascularized fibular strut graft with wrist arthrodesis is a good option for wrist reconstruction and provides a good forearm function and strength.
A Comparative Study between Platelet-Rich Plasma, Corticosteroid, and Autologous Whole Blood Injection in Patient of Plantar Fasciitis
Authors: Ravikant Utkarsh , Kumar Ashish , Sajid Imran , Dubey Siddharth , Pal Shashank Kumar
Published: December 2022

Introduction:

Majority of the patient with heel pain are diagnosed with plantar fasciitis (PF). PF is the condition characterized by isolated inferior heel pain particularly with the first steps of the day or after sitting for hours and the reason is due to degeneration of the plantar fascia and perifascial structures. Regular walking on hard surfaces, wearing hard sole footwear, and obesity are the risk factors for this condition. Injecting steroids is the most popular method of treating the condition but has its own advantages and disadvantages. There have been cases reported of rupture of plantar fascia after giving corticosteroid injections, especially when it was given repeatedly. Platelet-rich plasma (PRP) is known to enhance the healing process of the body as it has platelet-derived growth factors that boost the healing of soft tissue, bone healing, and also tendon healing.

Aims and Objective:

The objective of our study was to know among the PRP injection, autologous whole blood steroid injection which is a superior mode of intervention in PF management.

Materials and Methods:

A sample size of 225 was taken and patients were divided into 3 groups, in which Group A was given PRP injection, Group B was given steroid injection, and Group C was given whole blood. The follow-up was done on 2 weeks, 4 weeks, and 12 weeks. Patients of age more than 18, those who were clinically diagnosed PF, and those who were not improving with 3 months of conservative management were included in the study. Patients with any ligament injury or with Buerger’s disease, pseudo-gout, and Haglund disease were excluded from the study. All patients were asked for their pain to quantify it according to visual analog scale (VAS) scale and the score was noted on pre-injection follow by on 2 weeks, 4 weeks, and 12 weeks.

Results:

The VAS score before infiltration was almost similar (P > 0.05) in Group A (7.8 ± 1.26), Group B (7.5 ± 1.05), and Group C (7.8 ± 0.87). The VAS score significantly decreased in Group B who were injected steroids in the initial 2 weeks when compared to that of Group A who were injected PRP and Group C who were injected whole blood. A significant decrease in VAS was seen in Group A at after 12 weeks when compared to Group B and Group C.

Conclusion:

Our study showed that autologous PRP therapy can lead to a sustained reduction in symptom complaints when compared to corticosteroid injections and autologous whole blood. PRP injection holds promise as a potential therapy to hasten the healing of chronic PF.
Mucoid Degeneration of the Anterior Cruciate Ligament
Authors: Yadav Sanjay , Mittal Vaibhav , Ojha Ankur , Ansari Wamique
Published: December 2022

Mucoid degeneration of anterior cruciate ligament (ACL) is a rare pathological condition characterized by knee pain and restriction of movements. In this condition, ACL is infiltrated by mucoid (glycosaminoglycans) like material within its substance. We discuss the case and present a review of literature including clinical and radiological features and management options. We encountered a 33-year-old female complaining of increasing pain in right knee since last 6 years with difficulty in squatting and sitting cross-legged. There was no history of significant trauma or instability of the knee. Clinical examination demonstrated pain on deep knee flexion, negative Lachman, and anterior drawer test. Plain radiograph of knee suggested early onset degenerative changes of knee in the form of medial joint space reduction. Magnetic resonance imaging (MRI) showed hyperintense signal in ACL substance in T1W and T2W images which is classically described as Celery Stalk appearance on T2 STIR images. This was often mistaken as partial tear of ACL. Patient was planned for diagnostic arthroscopy. During arthroscopy, ACL was occupying the whole intercondylar notch. It was hypertrophied, homogenous, and firm. Arthroscopic debulking of ACL was done cautiously and mucoid tissue was removed. The specimen was sent for histopathological examination which confirmed the diagnosis of mucoid degeneration. Post-operatively patient was relieved of symptoms and was doing well without any specific complaints like instability till last follow up at 18 months. Repeat MRI was not done as patient was not symptomatic. Mucoid ACL degeneration affects active persons in third to fourth decade of life without significant trauma. MRI is the most useful tool for diagnosis with specific findings. If this disease is considered preoperatively, it can be diagnosed early. Treatment with debulking or partial resection shows good functional results.
Impact of Noise Exposure on Risk of Developing Stress-Related Metabolic Effects
Authors: Sivakumaran Kapeena , Ritonja Jennifer A. , Waseem Haya , AlShenaiber Leena , Morgan Elissa , Ahmadi Salman A. , Denning Allison , Michaud David , Morgan Rebecca L.
Published: December 2022

Background:

Exposure to noise can increase biological stress reactions, which may increase adverse health effects, including metabolic disorders; however, the certainty in the association between exposure to noise and metabolic outcomes has not been widely explored. The objective of this review is to evaluate the evidence between noise exposures and metabolic effects.

Materials and Methods:

A systematic review of English and comparative studies available in PubMed, Cochrane Central, EMBASE, and CINAHL databases between January 1, 1980 and December 29, 2021 was performed. Risk of Bias of Nonrandomized Studies of Exposures was used to assess risk of bias of individual studies and certainty of the body of evidence for each outcome was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.

Results:

Fifty-six primary studies reporting on cortisol, cholesterol levels, waist circumference, glucose levels, and adrenaline and/or noradrenaline were identified. Although meta-analyses suggested that there may be an increase in waist circumference and adrenaline with increased noise exposure, the certainty in the evidence is very low. Overall, the certainty in the evidence of an effect of increased noise on all the outcomes were low to very low due to concerns with risk of bias, inconsistency across exposure sources, populations, and studies, and imprecision in the estimates of effects.

Conclusions:

The certainty of the evidence of increased noise on metabolic effects was low to very low, which likely reflects the inability to compare across the totality of the evidence for each outcome. The findings from this review may be used to inform policies involving noise reduction and mitigation strategies, and to direct further research in areas that currently have limited evidence available.
Quantifying the Effect of Noise on Cognitive Processes
Authors: Grenzebach Jan , Romanus Erik
Published: December 2022

Noise is present in most work environments, including emissions from machines and devices, irrelevant speech from colleagues, and traffic noise. Although it is generally accepted that noise below the permissible exposure limits does not pose a considerable risk for auditory effects like hearing impairments. Yet, noise can have a direct adverse effect on cognitive performance (non-auditory effects like workload or stress). Under certain circumstances, the observable performance for a task carried out in silence compared to noisy surroundings may not differ. One possible explanation for this phenomenon needs further investigation: individuals may invest additional cognitive resources to overcome the distraction from irrelevant auditory stimulation. Recent developments in measurements of psychophysiological correlates and analysis methods of load-related parameters can shed light on this complex interaction. These objective measurements complement subjective self-report of perceived effort by quantifying unnoticed noise-related cognitive workload. In this review, literature databases were searched for peer-reviewed journal articles that deal with an at least partially irrelevant “auditory stimulation” during an ongoing “cognitive task” that is accompanied by “psychophysiological correlates” to quantify the “momentary workload.” The spectrum of assessed types of “auditory stimulations” extended from speech stimuli (varying intelligibility), oddball sounds (repeating short tone sequences), and auditory stressors (white noise, task-irrelevant real-life sounds). The type of “auditory stimulation” was related (speech stimuli) or unrelated (oddball, auditory stressor) to the type of primary “cognitive task.” The types of “cognitive tasks” include speech-related tasks, fundamental psychological assessment tasks, and real-world/simulated tasks. The “psychophysiological correlates” include pupillometry and eye-tracking, recordings of brain activity (hemodynamic, potentials), cardiovascular markers, skin conductance, endocrinological markers, and behavioral markers. The prevention of negative effects on health by unexpected stressful soundscapes during mental work starts with the continuous estimation of cognitive workload triggered by auditory noise. This review gives a comprehensive overview of methods that were tested for their sensitivity as markers of workload in various auditory settings during cognitive processing.
A Cross-Sectional Study on the Effect of Chronic Noise Exposure on the Vestibular Function of Traffic Policemen and Automobile Drivers
Authors: Das Soumyajit , Kalidoss Vinoth Kumar , Bakshi Satvinder Singh , Ramesh Seepana
Published: December 2022

Introduction:

Noise is a preventable occupational hazard for certain professions like automobile drivers and traffic police personnel. The harmful auditory effects of noise are well known. However, little is known about the status of the vestibular function in chronic noise exposure without noise induced hearing loss. Our objective was to assess the vestibular function in chronic noise exposure.

Methodology:

The study was conducted with a sample size of 242 (chronic noise exposure group − 121, group without chronic noise exposure − 121). Noise estimation was carried out across various traffic intersections to assess the noise exposure levels of the exposed group. All participants underwent a detailed vestibular evaluation in the clinical vestibulometry laboratory.

Results:

There was no difference in nystagmus, saccades, caloric function between the two groups. The latency and amplitude of vestibular evoked myogenic potentials (VEMP) were similar in both the groups. However, dynamic posturography showed a significant difference in the Adaptation test between the two groups (P < 0.05). We also found a statistically significant difference between the static and dynamic subjective visual vertical (SVV) and the dynamic visual acuity (DVA) between the two groups (P < 0.05).

Conclusion:

We did not find any clinical evidence of vestibular dysfunction in the noise exposed group. However, the statistical significance of SVV and DVA as seen in this study needs to be evaluated further as an early marker for vestibular dysfunction. It remains to be seen whether the statistically significant prolongation is reversible after the noise exposure is withdrawn.
Do Lower Costs for Applicants Come at the Expense of Program Perception? A Cross-Sectional Survey Study of Virtual Residency Interviews
Authors: Wang Sheri , Denham Zachary , Ungerman Elizabeth A. , Stollings Lindsay , McCausland Julie B. , Hamilton Melinda Fiedor , Gonzaga Alda Maria , Bump Gregory M. , Metro David G. , Adams Phillip S.
Published: December 2022

Background

Travel costs and application fees make in-person residency interviews expensive, compounding existing financial burdens on medical students. We hypothesized virtual interviews (VI) would be associated with decreased costs for applicants compared to in-person interviews (IPI) but at the expense of gathering information with which to assess the program.

Objective

To survey senior medical students and postgraduate year (PGY)-1 residents regarding their financial burden and program perception during virtual versus in-person interviews.

Methods

The authors conducted a single center, multispecialty study comparing costs of IPI vs VI from 2020-2021. Fourth-year medical students and PGY-1 residents completed one-time surveys regarding interview costs and program perception. The authors compared responses between IPI and VI groups. Potential debt accrual was calculated for 3- and 7-year residencies.

Results

Two hundred fifty-two (of 884, 29%) surveys were completed comprising 75 of 169 (44%) IPI and 177 of 715 (25%) VI respondents. The VI group had significantly lower interview costs compared to the IPI group (median $1,000 [$469-$2,050 IQR] $784-$1,216 99% CI vs $3,200 [$1,700-$5,500 IQR] $2,404-$3,996 99% CI, P<.001). The VI group scored lower for feeling the interview process was an accurate representation of the residency program (3.3 [0.5] vs 4.1 [0.7], P<.001). Assuming interview costs were completely loan-funded, the IPI group will have accumulated potential total loan amounts $2,334 higher than the VI group at 2% interest and $2,620 at 6% interest. These differences were magnified for a 7-year residency.

Conclusions

Virtual interviews save applicants thousands of dollars at the expense of their perception of the residency program.
Machine Translation and Gender biases in video game localisation: a corpus-based analysis
Authors: Rivas Ginel María , Theroine Sarah
Published: December 2022

The video game industry has been a historically gender-biased terrain due to a higher number of male protagonists and hypersexualised representations [Dietz, 1998; Downs & Smith, 2010; Lynch et al., 2016]. Nowadays, echoing the debate on inclusive language, companies attempt to erase gender disparity by introducing main female characters as well as non-binary characters. From a technological point of view, even though recent studies show that Machine Translation remains largely unadopted by individual video game localisers [Rivas Ginel, 2021], multilanguage vendors are willing to invest in these tools to reduce costs [LIND, 2020]. However, the predominance of the masculine in Natural Language Processing and Machine Learning has created allocation and representation biases in Neural Machine Translation [Crawford, 2017].This paper aims to analyse the percentage of gender bias resulting from the use of Google Translate, DeepL, and SmartCat when translating in-game raw content from English into French. The games DeltaRune, The Devil's Womb and The Faces of the Forest were chosen due to the presence of non-binary characters, non-sexualized characters, and female protagonists. We compared the results in order to recount and analyse the differences between these tools' output when in terms of errors related to gender. To this end, we created a parallel corpus to compare source documents and all the translations to visualise the semantic and grammatical directions of the words embeddings [Zhou; Shi; Zhao and al, 2019] and extracted the collocations and concordance lines that represented gender identity by analysing the patterns in the source language.
Voyage au bout de la traduction automatique
Authors: Bassole Jean-Yves
Published: December 2022

Des outils de traduction automatique, dont certains sont très performants, sont mis gratuitement à la disposition du public ; cette réalité est à prendre en considération dans l'enseignement de la traduction. L'étude qui suit porte sur une série de phrases extraites de l'oeuvre de Louis-Ferdinand Céline et relevant de la langue parlée, voire populaire, ou présentant un caractère proverbial. Sept moteurs de traduction automatique (Bing Microsoft Translator, DeepL, Google Translate, Promt, Reverso, Systran et Yandex) ont été testés à plusieurs reprises et à partir de postes de travail différents pour traduction vers l'anglais (britannique, dans les cas où cette option est offerte). L'examen des traductions proposées par ces sept moteurs permet de constater l'absence fréquente de stabilité dans les traductions proposées ; il permet également d'identifier les points faibles des systèmes moyennant une première analyse des erreurs de compréhension et de traduction.
IBM PENGEMBANGAN MEDIA PEMBELAJARAN JARAK JAUH BERBASIS KURIKULUM MERDEKA BELAJAR DI SDN 5 KARANGSARI BANYUWANGI
Authors: Hardiyanti Siska Aprilia , Yustita Aprilia Divi , Ermawati Eka Afrida
Published: December 2022

The outbreak of the Covid-19 pandemic has impacted the public sector with various problems and crises, including the education sector. The government through the Ministry of Education and Culture (Kemendikbud) finally implemented a learning from home (LFH) policy and the implementation of an independent learning curriculum (Kurikulum Merdeka Belajar). The independent learning curriculum was created as an answer to many complaints about Indonesian education system. The independent learning curriculum has a concept in building a national education system and returns to the essence of the law by giving freedom to the academic community starting from teachers as the driving force of national education. The purpose of this service activity is to assist teachers in understanding the nature of Kurikulum Merdeka Belajar and to create learning media that are relevant to the curriculum by maximizing the use of information and communication technology used in everyday life. The method used in this service is the implementation of free learning curriculum workshops and training on the creation of technology-based innovative learning media. As a result of this service, teachers are able to create interesting learning media and then used inteaching and learning process.
PENANAMAN KESADARAN PENTINGNYA PENDIDIKAN DAN MOTIVASI BELAJAR SEBAGAI UPAYA PENCEGAHAN PUTUS SEKOLAH BAGI SISWA SDN LEMAH ABANG
Authors: Mahuda Isnaini , Layli Dewi Anita , Alfianti Regita , Abizar M. Adlan , F Nur Aini
Published: December 2022

Education is the key in determining the future of the nation's next generation. Seeing the importance of education, the government always tries to give serious attention in overcoming problems in the field of education. One of the problems that currently plagues the world of education is the high dropout rate for children. Banten Province is a province in Indonesia where cases of dropping out of school in children are still quite high, including Serang City as the provincial capital. Team of KKM-PkM UNIBA 04 with a service location in Warung Jaud Village, Kasemen District, Serang City seeks to help provide solutions in preventing children from dropping out of school through motivational seminars with the aim of instilling awareness of the importance of education and motivating children to be enthusiastic about learning. The activity was carried out at SDN Lemah Abang with students in grades 5 and 6. The method used consisted of several stages including the pre-activity stage, the activity preparation stage, the activity implementation stage and the activity evaluation stage. As for the results of this activity, it was concluded that: 1) community service activities in the form of motivational seminars went well and were followed with great enthusiasm by the seminar participants; 2) this activity can be a preventive effort in dealing with cases of children dropping out of school by instilling awareness of the importance of education and motivating students to be enthusiastic about learning
PELATIHAN MEMBANGUN USAHA DIGITAL UNTUK MENUMBUHKAN JIWA ENTERPRENEURSHIP BAGI SISWA SMK MUHAMMADIYAH 2 PEKANBARU
Authors: Saputra Haris Tri , Yulisman Yulisman , Zulkifli Akhmad , Rahmalisa Uci
Published: December 2022

Digital and technology or a tool that is currently almost always there in every aspect of human life that has a goal to help and facilitate work or activities carried out by humans. The impact of digital technology is felt, especially for those who depend on technology for their daily activities. Digital businesses are currently growing and developing very quickly. To build a digital business requires adequate experience and knowledge, and to get this it is enough to take part in training. Training should be carried out early or starting at the school level, especially training for Vocational High School (SMK) students, because SMK students after graduation are targeted to be able to work immediately. The results of this training can be seen from the post-training questionnaire that participants