bluuebunny/crossref_metadata_2025 huggingface dataset:
Long-term warming altered soil physical structure and soil organic carbon pools in wheatland field
Authors: Ma Rentian , Kou Taiji , Cheng Xianghan , Yu Ning
Published: January 2024

The impacts of long-term warming on soil physical structure and soil organic carbon (SOC) pools are currently disputed and uncertain. We conducted an eleven-year warming experiment in wheatland field in Henan, China. We found that long-term warming significantly increased soil bulk density by 4.5%, and significantly decreased total porosity and non-capillary porosity by 3.4% and 5.0%, respectively. Besides, long-term warming decreased the >2 mm fraction proportion and increased <0.053 mm fraction proportion of dry and wet aggregates. The mean weight diameter value for dry and wet aggregates in long-term warming treatment was significantly decreased by 7.0% and 6.7%, respectively. Moreover, long-term warming significantly decreased the total SOC, very labile pool (F1) and labile pool (F2) content by 10.6%, 30.6%, and 43.6%, and significantly increased the less labile pool (F3) and non-labile pool (F4) content by 94.2% and 21.1%, respectively. Long-term warming increased the passive carbon pool percentage but decreased the active carbon pool (ACP) percentage. Our results suggest that long-term warming negatively affected the soil's physical structure and impaired soil ACP accumulation. The findings of this study help improve our understanding of the response of farmland soils in northern China to climate change and provide scientific basis for establishing carbon management measures in farmland.
Navigating “Sensitive” States: How Surveillance Practices Affect Research Development between the United States and Iran
Authors: Nesvaderani Nat
Published: January 2024

I had completed two months of exploratory dissertation research in Tehran in the winter of 2015 when I was called in for questioning by two men who declined to provide me with their names or that of the office they called from. We met in an unmarked building adjacent to the Ministry of Foreign Affairs in downtown Tehran. They were middle-aged and sat on opposite sides of a table with a framed picture of Ayatollah Khomeini. When they offered me tea, I declined, remembering my cousins’ hurried advice an hour earlier. “God forbid someone puts something in your drink and they take you away to a different location,” he had said.
Recent trends in populations of Critically Endangered Gyps vultures in India
Authors: Prakash Vibhu , Bajpai Hemant , Chakraborty Soumya S. , Singh Mahadev Manan , Mallord John W. , Prakash Nikita , Ranade Sachin P. , Shringarpure Rohan N. , Bowden Christopher G. R. , Green Rhys E.
Published: January 2024

This paper reports results from the eighth of a series of road transect surveys of Gyps vultures conducted across northern, central, western, and north-eastern India since the early 1990s. Populations of the White-rumped Vulture Gyps bengalensis, Indian Vulture G. indicus, and Slender-billed Vulture G. tenuirostris declined rapidly, beginning in the mid-1990s. The principal cause of the declines was poisoning due to widespread veterinary use of the non-steroidal anti-inflammatory drug (NSAID) diclofenac on cattle. The results of the current survey suggest that, while populations of all three species of vulture remain at a low level with no signs of recovery, they appear to have been approximately stable since veterinary use of diclofenac was banned in the mid-2000s. Population trends in India, where the illegal use of diclofenac and legal use of other toxic NSAIDs continues, are compared with more positive trends in Nepal, where the veterinary use of toxic NSAIDs appears to have been reduced to a low level.
Urban school neighbourhoods dominated by unhealthy food retailers and advertisements in Greater Tunis: a geospatial study in the midst of the nutrition transition
Authors: Akl Christelle , El-Helou Nehmat , Safadi Gloria , Semaan Aline , El Sammak Aya , Trabelsi Tarek , Sassi Sonia , Akik Chaza , El Ati Jalila , Traissac Pierre , Ghattas Hala ,   The SCALE Research Group
Published: January 2024

Objective:

Food environments are a major determinant of children’s nutritional status. Scarce evidence on food environments exists in low- and middle-income countries (LMIC). This study aims to fill this gap by documenting the obesogenicity of food environments around schools in Greater Tunis, Tunisia – an LMIC of the Middle East and North Africa region with an ongoing nutrition transition and increasing rates of childhood obesity.

Design:

In this cross-sectional study, we assessed built food environments around fifty primary schools. Ground-truthing was performed to collect geographic coordinates and pictures of food retailers and food advertisement sets within an 800-m road network buffer of each school. Retailers and advertisement sets were categorised as healthy or unhealthy according to a NOVA-based classification. Associations between school characteristics and retailers or advertisement sets were explored using multinomial regression models.

Setting:

Greater Tunis, Tunisia.

Participants:

Random sample of fifty (thirty-five public and fifteen private) primary schools.

Results:

Overall, 3621 food retailers and 2098 advertisement sets were mapped. About two-thirds of retailers and advertisement sets were labelled as unhealthy. Most retailers were traditional corner stores (22 %) and only 6 % were fruit and vegetable markets. The prevailing food group promoted was carbonated and sugar-sweetened beverages (22 %). The proportion of unhealthy retailers was significantly higher in the richest v. poorest areas.

Conclusions:

School neighbourhood food environments included predominantly unhealthy retailers and advertisements. Mapping of LMIC food environments is crucial to document the impact of the nutrition transition on children’s nutritional status. This will inform policies and interventions to curb the emergent childhood obesity epidemic.
Adaptation of a Cultural Measure in Brazil – Developing a Short Version of the Individualism–Collectivism Vertical–Horizontal Scale
Authors: Pérez-Nebra Amalia Raquel , Fischer Ronald , Torres Cláudio V. , Boehnke Klaus
Published: January 2024

Abstract: We report psychometric analyses of an adapted version of the measure of individualism–collectivism (IC) and its horizontal–vertical (HV) manifestations ( Singelis et al., 1995 ) for Brazilian samples. We used a large sample ( N = 1,669) split into an exploratory and two cross-validation samples. Using confirmatory factor analysis and a new metaheuristic machine learning approach inspired by ant colony foraging, we found poor psychometric properties. We developed and compared three short scales, which showed poor reliability and poor factor structures. Considering widely used short scales of this measure, our results suggest that key items may be understood differently by Brazilians, and we urge caution in interpreting individualism–collectivism scores with Brazilian samples. We discuss issues for further developing cultural orientation scales to measure individual differences and the utility of an advanced metaheuristic data-driven approach for psychometric research.
Association Between Air Pollution and Cardiovascular Disease Hospitalizations in Lanzhou City, 2013–2020: A Time Series Analysis
Authors: Yu Jingze , Zhu Anning , Liu Miaoxin , Dong Jiyuan , Chen Rentong , Tian Tian , Liu Tong , Ma Li , Ruan Ye
Published: January 2024

Extensive evidence has shown that air pollution increases the risk of cardiovascular disease (CVD) admissions. We aimed to explore the short‐term effect of air pollution on CVD admissions in Lanzhou residents and their lag effects. Meteorological data, air pollution data, and a total of 309,561 daily hospitalizations for CVD among urban residents in Lanzhou were collected from 2013 to 2020. Distributed lag non‐linear model was used to analyze the relationship between air pollutants and CVD admissions, stratified by gender, age, and season. PM2.5, NO2, and CO have the strongest harmful effects at lag03, while SO2 at lag3. The relative risks of CVD admissions were 1.0013(95% CI: 1.0003, 1.0023), 1.0032(95% CI: 1.0008, 1.0056), and 1.0040(95% CI: 1.0024, 1.0057) when PM2.5, SO2, and NO2 concentrations were increased by 10 μg/m³, respectively. Each 1 mg/m3 increase in CO concentration was associated with a relative risk of cardiovascular hospitalization of risk was 1.0909(95% CI: 1.0367, 1.1479). We observed a relative risk of 0.9981(95% CI: 0.9972, 0.9991) for each 10 μg/m³ increase in O3 for CVD admissions at lag06. We found a significant lag effects of air pollutants on CVD admissions. NO2 and CO pose a greater risk of hospitalization for women, while PM2.5 and SO2 have a greater impact on men. PM2.5, NO2, and CO have a greater impact on CVD admissions in individuals aged <65 years, whereas SO2 affects those aged ≥65 years. Our research indicates a possible short‐term impact of air pollution on CVD. Local public health and environmental policies should take these preliminary findings into account.
Cell competition and cancer from Drosophila to mammals
Authors: Cong Bojie , Cagan Ross L.
Published: January 2024

Throughout an individual’s life, somatic cells acquire cancer-associated mutations. A fraction of these mutations trigger tumour formation, a phenomenon partly driven by the interplay of mutant and wild-type cell clones competing for dominance; conversely, other mutations function against tumour initiation. This mechanism of ‘cell competition’, can shift clone dynamics by evaluating the relative status of clonal populations, promoting ‘winners’ and eliminating ‘losers’. This review examines the role of cell competition in the context of tumorigenesis, tumour progression and therapeutic intervention.
Application of power battery under thermal conductive silica gel plate in new energy vehicles
Authors: Ma Hang , Zong Shirong , Wan Banglong , Wang Guodong , Tian Qiang
Published: January 2024

This study aims to improve the performance of automotive battery thermal management systems (BTMS) to achieve more efficient heat dissipation and thus reduce hazards during driving. Firstly, the research parameters and properties of composite thermally conductive silicone materials are introduced. Secondly, the heating principle of the power battery, the structure and working principle of the new energy vehicle battery, and the related thermal management scheme are discussed. Finally, the research results are presented from the experimental test and controller design. In addition, to achieve the research goal, the composite thermally conductive silica gel plate (CSGP) material is studied in detail and parametrically analyzed, and the heating mechanism of the power battery is discussed in depth. The temperature characteristics after adding CSGP are experimentally tested, and the controller of the BTMS of the new energy vehicle is designed, including hardware circuits and software modules. The findings show that the temperature characteristics of the battery module have obvious limitations without CSGP. When the battery module operates at a 4C magnification, the temperature exceeds the safety threshold by 38.4%, with particular potential safety risks. Then, the maximum temperature of the battery module with CSGP can be controlled within 50 °C, and the temperature characteristics are prominently improved. Lastly, the controller of the BTMS is tested, and the results reveal that it has remarkable voltage recovery ability. According to the research results, the performance of automotive BTMS can be significantly improved, and better heat dissipation can be effectively achieved by adding CSGP. This helps reduce the hazards of driving. Moreover, the designed controller performs well in voltage recovery, providing solid theoretical support for further developing the CSGP battery management system.
Prognostic value of mitochondrial CKMT2 in Pan-cancer and its tumor immune correlation analysis
Authors: Lin Wei , Zhou Jiamin , Ma Yili , Ge Liuxing , Luo Yiling , Wang Yaobin , Zhou Sufang
Published: January 2024

Mitochondrial metabolism has been shown to play a key role in immune cell survival and function, but mitochondrial creatine kinase 2 (CKMT2) has been relatively little studied about tumor immunity. We aimed to explore the prognostic value of CKMT2 in 33 cancer types and investigate its potential immune function. We used a range of bioinformatics approaches to explore the potential carcinogenic role of CKMT2 in multiple cancers. CKMT2 was lowly expressed in 14 tumor tissues and highly expressed in 4 tumor tissues. Immunohistochemical assays showed overexpression of CKMT2 in colon cancer and rectal cancer. CKMT2 overexpression was positively correlated with the prognosis of lung adenocarcinoma and prostate cancer. CKMT2 overexpression is mainly enriched in the adaptive immune system and immune regulatory pathways of immunoglobulins. Seven cancers were positively correlated with low CKMT2 expression in tumor microenvironment analysis. Among the five cancers, low expression of CKMT2 resulted in better immunotherapy treatment outcomes. There was a strong correlation between CKMT2 and most immune-related genes in specific cancer types. CKMT2 plays an important role in tumorigenesis and cancer immunity and can be used as a prognostic biomarker and potential target for cancer immunotherapy.
Association of thyroid cancer with human papillomavirus infections
Authors: Yang Tzong-Hann , Hung Shih-Han , Cheng Yen-Fu , Chen Chin-Shyan , Lin Herng-Ching
Published: January 2024

While Human Papillomavirus (HPV) particles have been detected in a small proportion of benign thyroid nodules or thyroid cancer cases, a role of HPV in these thyroid conditions has not been established. This study aims to investigate the association of HPV infection with thyroid cancer (TC) using a nationwide population-based study. We retrieved data for this case–control study from Taiwan's Longitudinal Health Insurance Database 2010. The study sample included 3062 patients with TC and 9186 propensity-scored matched controls. We employed multivariate logistic regression models to quantitatively evaluate the association of TC with HPV infections after taking age, sex, monthly income, geographic location and urbanization level of the patient's residence, diabetes, hypertension, and hyperlipidemia into considerations. Chi-squared test revealed that there was a significant difference in the prevalence of prior HPV infections between patients with TC and controls (15.3% vs. 7.6%, p < 0.001). The adjusted odds ratio of prior HPV infections for patients with TC was 2.199 (95% CI = 1.939–2.492) relative to controls. The adjusted ORs of prior HPV infections for patients with TC was similar for males and females. Our research suggests a significant link between HPV infection and the development of TC.
Deep learning driven segmentation of maxillary impacted canine on cone beam computed tomography images
Authors: Swaity Abdullah , Elgarba Bahaaeldeen M. , Morgan Nermin , Ali Saleem , Shujaat Sohaib , Borsci Elena , Chilvarquer Israel , Jacobs Reinhilde
Published: January 2024

The process of creating virtual models of dentomaxillofacial structures through three-dimensional segmentation is a crucial component of most digital dental workflows. This process is typically performed using manual or semi-automated approaches, which can be time-consuming and subject to observer bias. The aim of this study was to train and assess the performance of a convolutional neural network (CNN)-based online cloud platform for automated segmentation of maxillary impacted canine on CBCT image. A total of 100 CBCT images with maxillary canine impactions were randomly allocated into two groups: a training set (n = 50) and a testing set (n = 50). The training set was used to train the CNN model and the testing set was employed to evaluate the model performance. Both tasks were performed on an online cloud-based platform, ‘Virtual patient creator’ (Relu, Leuven, Belgium). The performance was assessed using voxel- and surface-based comparison between automated and semi-automated ground truth segmentations. In addition, the time required for segmentation was also calculated. The automated tool showed high performance for segmenting impacted canines with a dice similarity coefficient of 0.99 ± 0.02. Moreover, it was 24 times faster than semi-automated approach. The proposed CNN model achieved fast, consistent, and precise segmentation of maxillary impacted canines.
Effects of altered gravity on growth and morphology in Wolffia globosa implications for bioregenerative life support systems and space-based agriculture
Authors: Romano Leone Ermes , van Loon Jack J. W. A. , Izzo Luigi Gennaro , Iovane Maurizio , Aronne Giovanna
Published: January 2024

Understanding the response of plants to varied gravitational conditions is vital for developing effective food production in space bioregenerative life support systems. This study examines the impact of altered gravity conditions on the growth and morphological responses of Wolffia globosa (commonly known as “water lentils” or “duckweed”), assessing its potential as a space crop. Although an experiment testing the effect of simulated microgravity on Wolffia globosa has been previously conducted, for the first time, we investigated the effect of multiple gravity levels on the growth and morphological traits of Wolffia globosa plants. The plant responses to simulated microgravity, simulated partial gravity (Moon), and hypergravity environments were evaluated using random positioning machines and the large-diameter centrifuge. As hypothesized, we observed a slight reaction to different gravitational levels in the growth and morphological traits of Wolffia globosa. The relative growth rates (RGR) of plants subjected to simulated microgravity and partial gravity were reduced when compared to those in other gravity levels. The morphological analysis revealed differences in plant dimensions and frond length-to-width ratios under diverse gravity conditions. Our findings showed that Wolffia globosa is responsive to gravitational changes, with its growth and morphological adaptations being slightly influenced by varying gravitational environments. As for other crop species, growth was reduced by the microgravity conditions; however, RGR remained substantial at 0.33 a day. In conclusion, this study underscores the potential of Wolffia globosa as a space crop and its adaptability to diverse gravitational conditions, contributing to the development of sustainable food production and bioregenerative life support systems for future space exploration missions.
Stronger EPR-steering criterion based on inferred Schrödinger–Robertson uncertainty relation
Authors: Naik Laxmi Prasad , Das Rakesh Mohan , Panigrahi Prasanta K.
Published: January 2024

Steering is one of the three in-equivalent forms of nonlocal correlations intermediate between Bell nonlocality and entanglement. Schrödinger–Robertson uncertainty relation (SRUR), has been widely used to detect entanglement and steering. However, the steering criterion in earlier works, based on SRUR, did not involve complete inferred-variance uncertainty relation. In this paper, by considering the local hidden state model and Reid’s formalism, we derive a complete inferred-variance EPR-steering criterion based on SRUR in the bipartite scenario. Furthermore, we check the effectiveness of our steering criterion with discrete variable bipartite two-qubit and two-qutrit isotropic states.
Antemortem detection of Mycobacterium bovis in nasal swabs from African rhinoceros
Authors: Dwyer Rebecca , Witte Carmel , Buss Peter , Warren Robin , Miller Michele , Goosen Wynand
Published: January 2024

Mycobacterium bovis (M. bovis) infection has been identified in black (Diceros bicornis) and white (Ceratotherium simum) rhinoceros populations in Kruger National Park, South Africa. However, it is unknown whether M. bovis infected rhinoceros, like humans and cattle, can shed mycobacteria in respiratory secretions. Limited studies have suggested that rhinoceros with subclinical M. bovis infection may present minimal risk for transmission. However, recent advances that have improved detection of Mycobacterium tuberculosis complex (MTBC) members in paucibacillary samples warranted further investigation of rhinoceros secretions. In this pilot study, nasal swab samples from 75 rhinoceros with defined infection status based on M. bovis antigen-specific interferon gamma release assay (IGRA) results were analysed by GeneXpert MTB/RIF Ultra, BACTEC MGIT and TiKa–MGIT culture. Following culture, speciation was done using targeted PCRs followed by Sanger sequencing for mycobacterial species identification, and a region of difference (RD) 4 PCR. Using these techniques, MTBC was detected in secretions from 14/64 IGRA positive rhinoceros, with viable M. bovis having been isolated in 11 cases, but not in any IGRA negative rhinoceros (n = 11). This finding suggests the possibility that MTBC/M. bovis-infected rhinoceros may be a source of infection for other susceptible animals sharing the environment.
Establishing associated risk factors, including fungal and parasitic infections among Malaysians living with schizophrenia
Authors: Franklin Freddy , Rajamanikam Arutchelvan , Phang Wei Kit , Raju Chandramathi Samudi , Gill Jesjeet Singh , Francis Benedict , Sy-Cherng Woon Luke , Govind Suresh Kumar
Published: January 2024

The aetiology of schizophrenia is multifactorial, and the identification of its risk factors are scarce and highly variable. A cross-sectional study was conducted to investigate the risk factors associated with schizophrenia among Malaysian sub-population. A total of 120 individuals diagnosed with schizophrenia (SZ) and 180 non-schizophrenic (NS) individuals participated in a questionnaire-based survey. Data of complete questionnaire responses obtained from 91 SZ and 120 NS participants were used in statistical analyses. Stool samples were obtained from the participants and screened for gut parasites and fungi using conventional polymerase chain reaction (PCR). The median age were 46 years (interquartile range (IQR) 37 to 60 years) and 35 years (IQR 24 to 47.75 years) for SZ and NS respectively. Multivariable binary logistic regression showed that the factors associated with increased risk of SZ were age, sex, unemployment, presence of other chronic ailment, smoking, and high dairy consumption per week. These factors, except sex, were positively associated with the severity of SZ. Breastfed at infancy as well as vitamin and supplement consumption showed a protective effect against SZ. After data clean-up, fungal or parasitic infections were found in 98% (39/42). of SZ participants and 6.1% (3/49) of NS participants. Our findings identified non-modifiable risk factors (age and sex) and modifiable lifestyle-related risk factors (unemployment, presence of other chronic ailment, smoking, and high dairy consumption per week) associated with SZ and implicate the need for medical attention in preventing fungal and parasitic infections in SZ.
Neutrophil-to-lymphocyte ratio is a prognostic factor reflecting immune condition of tumor microenvironment in squamous cell lung cancer
Authors: Ohashi Kana , Nishito Yukari , Fukuda Hironori , Sadahiro Ryoichi , Yoshida Yukihiro , Watanabe Shun-ichi , Motoi Noriko , Sonobe Yukiko , Mizuno Hideaki , Tsunoda Hiroyuki , Tatsumi Koichiro , Suzuki Takuji , Ochiai Atsushi , Aoki Kazunori
Published: January 2024

Inflammatory factors in the peripheral blood, such as the C-reactive protein level and neutrophil-to-lymphocyte ratio (NLR), are prognostic markers in multiple types of cancer, including non-small cell lung cancer (NSCLC). However, the association between inflammatory factors and prognosis based on histological types has not been adequately reported. In addition, the relationship between these factors and the immune condition of the tumor microenvironment (TME) is unclear. In this single center, retrospective study, we first investigated the relationship between preoperative inflammatory markers and clinical outcomes in 176 patients with NSCLC who underwent surgery. Lung adenocarcinoma (LUAD) showed no significant prognostic marker, whereas for lung squamous cell carcinoma (LUSC), a multivariate analysis showed that a high NLR was significantly associated with postoperative recurrence. In LUSC patients, the median time of postoperative recurrence-free survival in patients with a low NLR was longer than that in patients with a high NLR. We then compared the tumor-infiltrating lymphocyte (TIL) profile with inflammatory markers in peripheral blood and found that the NLR was negatively correlated with the frequencies of T cells and B cells in LUSC tissues. Thus, the NLR is a useful predictive biomarker for postoperative recurrence and may reflect the immune condition of the TME in LUSC.
Implementation of a dual-phase grating interferometer for multi-scale characterization of building materials by tunable dark-field imaging
Authors: Organista Caori , Tang Ruizhi , Shi Zhitian , Jefimovs Konstantins , Josell Daniel , Romano Lucia , Spindler Simon , Kibleur Pierre , Blykers Benjamin , Stampanoni Marco , Boone Matthieu N.
Published: January 2024

The multi-scale characterization of building materials is necessary to understand complex mechanical processes, with the goal of developing new more sustainable materials. To that end, imaging methods are often used in materials science to characterize the microscale. However, these methods compromise the volume of interest to achieve a higher resolution. Dark-field (DF) contrast imaging is being investigated to characterize building materials in length scales smaller than the resolution of the imaging system, allowing a direct comparison of features in the nano-scale range and overcoming the scale limitations of the established characterization methods. This work extends the implementation of a dual-phase X-ray grating interferometer (DP-XGI) for DF imaging in a lab-based setup. The interferometer was developed to operate at two different design energies of 22.0 keV and 40.8 keV and was designed to characterize nanoscale-size features in millimeter-sized material samples. The good performance of the interferometer in the low energy range (LER) is demonstrated by the DF retrieval of natural wood samples. In addition, a high energy range (HER) configuration is proposed, resulting in higher mean visibility and good sensitivity over a wider range of correlation lengths in the nanoscale range. Its potential for the characterization of mineral building materials is illustrated by the DF imaging of a Ketton limestone. Additionally, the capability of the DP-XGI to differentiate features in the nanoscale range is proven with the dark-field of Silica nanoparticles at different correlation lengths of calibrated sizes of 106 nm, 261 nm, and 507 nm.
Apply EZStrobe to simulate the finishing work for reducing construction process waste
Authors: Son Pham Vu Hong , Van Tien Pham
Published: January 2024

Vietnam, classified as a developing nation, encounters numerous challenges within its construction sector, including the scarcity of comprehensive and documented historical data regarding risks and a deficiency in embracing contemporary methodologies to mitigate the impact of risk factors on construction project objectives. This paper outlines initial findings from an ongoing research endeavor that centers on implementing Lean Construction (LC) techniques to enhance construction management practices specifically for marble floor finishing work within Vietnam. Therefore, this study aims to apply the construction lean principle combined with discrete-event simulation (DES) by using EZStrobe to simulate the marble floor finishing process in reality, from observing and collecting data of each activity in the actual process on the site. By building, running simulations, and resulting from real-world simulations, we'll understand the sources of waste, and then apply lean construction principles through methods such as just in time, reduce the batch size and resources priorities, and multi-skilled teams for the initial construction process. The study's lean modeling results has led to a 13% reduction in construction cycle time, a 141% improvement in process efficiency, a 268% enhancement in average productivity, and a 96% reduction in labor cost. The result has become the reference document resource for the managers and construction engineers to improve the performance of not only general finishing work but also marble floor finishing work.
Hybrid VMAT-3DCRT as breast cancer treatment improvement tool
Authors: Voyant Cyril , Pinpin Morgane , Leschi Delphine , Prapant Séverine , Savigny Françoise , Acquaviva Marie-Aimée
Published: January 2024

Radiation therapy is an important tool in the treatment of breast cancer and can play a crucial role in improving patient outcomes. For breast cancer, if the technique has been for a long time the use of 3DCRT, clinicians have seen the management evolve greatly in recent years. Field-in-field and IMRT approaches and more recently dynamic arctherapy are increasingly available. All of these approaches are constantly trying to improve tumour coverage and to preserve organs at risk by minimising the doses delivered to them. If arctherapy allows a considerable reduction of high doses received by healthy tissues, no one can deny that it also leads to an increase of low doses in tissues that would not have received any with other techniques. We propose a hybrid approach combining the robustness of the 3DCRT approach and the high technicality and efficiency of arctherapy. Statistical tests (ANOVA, Wilcoxon, determination coefficient, ROC, etc.) allow us to draw conclusions about the possibility of using the hybrid approach in certain cases (right breast, BMI $$> 23$$

>
23

, age $$> 48$$

>
48

, target volume $$> 350$$

>
350

cc, etc.). Depending on the breast laterality and patients morphological characteristics, hybridization may prove to be a therapeutic tool of choice in the management of breast cancer in radiotherapy.
Latitudinal variation in survival and immature development of Ceratitis capitata populations reared in two key overwintering hosts
Authors: Papadogiorgou Georgia D. , Papadopoulos Antonis G. , Moraiti Cleopatra A. , Verykouki Eleni , Papadopoulos Nikos T.
Published: January 2024

Ceratitis capitata, a major agricultural pest, is currently expanding its geographic distribution to northern, temperate areas of Europe. Its seasonal biology and invasion success depend on temperature, humidity and host availability. In coastal warmer Mediterranean regions and cooler temperature areas, bitter oranges and apples serve as overwintering hosts during the larval stage. We assessed the overwintering capacity of C. capitata populations obtained from different areas of the northern hemisphere by studying the survival and development rates of immature stages in both fruits under laboratory conditions. Eggs from each population were artificially inserted in the flesh of the two hosts and kept at 15, 20, or 25 °C until pupation and adult emergence. Climatic analysis of the area of the population origin showed combined effects of latitude, host and macroclimatic variables on immature survival and development rates. Egg to adult survival rates and developmental duration were longer in apples than in bitter oranges. For populations originated from southern-warmer areas, egg to adult developmental duration was prolonged and adult emergence reduced at 15 °C compared to those populations obtained from northern regions. Our findings reveal varying plastic responses of medfly populations to different overwintering hosts and temperatures highlighting the differential overwintering potential as larvae within fruits. This study contributes towards better understanding the medfly invasion dynamics in temperate areas of Northern Europe and other parts of the globe with similar climates.
Group I pharmaceuticals of IARC and associated cancer risks: systematic review and meta-analysis
Authors: Lim Woojin , Moon Sungji , Lee Na Rae , Shin Ho Gyun , Yu Su-Yeon , Lee Jung Eun , Kim Inah , Ko Kwang-Pil , Park Sue K.
Published: January 2024

We aimed to summarize the cancer risk among patients with indication of group I pharmaceuticals as stated in monographs presented by the International Agency for Research on Cancer working groups. Following the PRISMA guidelines, a comprehensive literature search was conducted using the PubMed database. Pharmaceuticals with few studies on cancer risk were identified in systematic reviews; those with two or more studies were subjected to meta-analysis. For the meta-analysis, a random-effects model was used to calculate the summary relative risks (SRRs) and 95% confidence intervals (95% CIs). Heterogeneity across studies was presented using the Higgins I square value from Cochran’s Q test. Among the 12 group I pharmaceuticals selected, three involved a single study [etoposide, thiotepa, and mustargen + oncovin + procarbazine + prednisone (MOPP)], seven had two or more studies [busulfan, cyclosporine, azathioprine, cyclophosphamide, methoxsalen + ultraviolet (UV) radiation therapy, melphalan, and chlorambucil], and two did not have any studies [etoposide + bleomycin + cisplatin and treosulfan]. Cyclosporine and azathioprine reported increased skin cancer risk (SRR = 1.32, 95% CI 1.07–1.62; SRR = 1.56, 95% CI 1.25–1.93) compared to non-use. Cyclophosphamide increased bladder and hematologic cancer risk (SRR = 2.87, 95% CI 1.32–6.23; SRR = 2.43, 95% CI 1.65–3.58). Busulfan increased hematologic cancer risk (SRR = 6.71, 95% CI 2.49–18.08); melphalan was associated with hematologic cancer (SRR = 4.43, 95% CI 1.30–15.15). In the systematic review, methoxsalen + UV and MOPP were associated with an increased risk of skin and lung cancer, respectively. Our results can enhance persistent surveillance of group I pharmaceutical use, establish novel clinical strategies for patients with indications, and provide evidence for re-categorizing current group I pharmaceuticals into other groups.
RETRACTED ARTICLE: A comprehensive scrutiny to controlled dipolar interactions to intensify the self-heating efficiency of biopolymer encapsulated Tb doped magnetite nanoparticles
Authors: Hazarika Krishna Priya , Borah J. P.
Published: January 2024

An exciting prospect in the field of magnetic fluid hyperthermia (MFH) has been the integration of noble rare earth elements with biopolymers (chitosan/dextran) that have optimum structures to tune specific effects on magnetic nanoparticles (MNPs). Remarkably, it has been demonstrated that dipole–dipole interactions have a significant influence on nanoparticle dynamics. In this article, we present an exhaustive scrutiny of dipolar interactions and how this affects the efficiency of MFH applications. In particular, we prepare chitosan and dextran-coated Tb-doped MNPs and study whether it is possible to increase the heat released by controlling the dipole–dipole interactions. It has been indicated that even moderate control of agglomeration may substantially impact the structure and magnetization dynamics of the system. Besides estimating the specific loss power value, our findings provide a deep insight into the relaxation mechanisms and bring to light how to tune the self-heating efficacy towards magnetic hyperthermia.
Medical image encryption algorithm based on a new five-dimensional multi-band multi-wing chaotic system and QR decomposition
Authors: Zhuang Zeben , Zhuang Zhiben , Wang Tao
Published: January 2024

In this study, we propose a medical image encryption algorithm based on a new five-dimensional (5D) multi-band multi-wing chaotic system and QR decomposition. First, we construct a new 5D multi-band multi-wing chaotic system through feedback control, which has a relatively large Lyapunov exponent. Second, we decompose the plaintext image matrix and chaotic sequence into an orthogonal matrix and upper triangular matrix using QR decomposition. We multiply the orthogonal matrix decomposed from the original image by the orthogonal matrix decomposed from the chaotic sequence. In this process, we use the chaotic sequence to control left and right multiplication. Simultaneously, we chaotically rearrange the elements in the upper triangular matrix using the improved Joseph loop and then multiply the two resulting matrices. Finally, we subject the product matrix to bit-level scrambling. From the theoretical analysis and simulation results, we observed that the key space of this method was relatively large, the key sensitivity was relatively strong, it resisted attacks of statistical analysis and gray value analysis well, and it had a good encryption effect for medical images.
Mesenchymal–epithelial transition and AXL inhibitor TP-0903 sensitise triple-negative breast cancer cells to the antimalarial compound, artesunate
Authors: Terragno Mirko , Vetrova Anastassiya , Semenov Oleg , Sayan A. Emre , Kriajevska Marina , Tulchinsky Eugene
Published: January 2024

Triple-negative breast cancer (TNBC) is a difficult-to-treat, aggressive cancer type. TNBC is often associated with the cellular program of epithelial-mesenchymal transition (EMT) that confers drug resistance and metastasis. EMT and reverse mesenchymal-epithelial transition (MET) programs are regulated by several signaling pathways which converge on a group of transcription factors, EMT- TFs. Therapy approaches could rely on the EMT reversal to sensitise mesenchymal tumours to compounds effective against epithelial cancers. Here, we show that the antimalarial ROS-generating compound artesunate (ART) exhibits higher cytotoxicity in epithelial than mesenchymal breast cancer cell lines. Ectopic expression of EMT-TF ZEB1 in epithelial or ZEB1 depletion in mesenchymal cells, respectively, reduced or increased ART-generated ROS levels, DNA damage and apoptotic cell death. In epithelial cells, ZEB1 enhanced expression of superoxide dismutase 2 (SOD2) and glutathione peroxidase 8 (GPX8) implicated in ROS scavenging. Although SOD2 or GPX8 levels were unaffected in mesenchymal cells in response to ZEB1 depletion, stable ZEB1 knockdown enhanced total ROS. Receptor tyrosine kinase AXL maintains a mesenchymal phenotype and is overexpressed in TNBC. The clinically-relevant AXL inhibitor TP-0903 induced MET and synergised with ART to generate ROS, DNA damage and apoptosis in TNBC cells. TP-0903 reduced the expression of GPX8 and SOD2. Thus, TP-0903 and ZEB1 knockdown sensitised TNBC cells to ART, likely via different pathways. Synergistic interactions between TP-0903 and ART indicate that combination approaches involving these compounds can have therapeutic prospects for TNBC treatment.
Modeling advanced air mobility aircraft in data-driven reduced order realistic urban winds
Authors: Vuppala Rohit K. S. S. , Krawczyk Zack , Paul Ryan , Kara Kursat
Published: January 2024

The concept of Advanced Air Mobility involves utilizing cutting-edge transportation platforms to transport passengers and cargo efficiently over short distances in urban and suburban areas. However, using simplified atmospheric models for aircraft simulations can prove insufficient for modeling large disturbances impacting low-altitude flight regimes. Due to the complexities of operating in urban environments, realistic wind modeling is necessary to ensure trajectory planning and control design can maintain high levels of safety. In this study, we simulate the dynamic response of a representative advanced air mobility platform operating in wing-borne flight through an urban wind field generated using Large Eddy Simulations (LES) and a wind field created using reduced-order models based on full-order computational solutions. Our findings show that the longitudinal response of the aircraft was not greatly affected by the fidelity of the LES models or if the spatial variation was considered while evaluating the full-order wind model. This is encouraging as it indicates that the full LES generation of the wind field may not be necessary, which decreases the complexity and time needed in this analysis. Differences are present when comparing the lateral response, owing to the differences in the asymmetric loading of the planform in the full and reduced order models. These differences seen in the lateral responses are expected to increase for planforms with smaller wing loadings, which could pose challenges. Additionally, the response of the aircraft to the mean wind field, the temporal average of the full order model, was misrepresentative in the longitudinal response and greatly under-predicted control surface activity, particularly in the lateral response.
Whole transcriptome sequencing for revealing the pathogenesis of sporotrichosis caused by Sporothrix globosa
Authors: Liu Zhe , Li Su-Shan , Zhang Gui-Yun , Lv Sha , Wang Shuang , Li Fu-Qiu
Published: January 2024

This study aimed to investigate the molecular mechanism of sporotrichosis and identify possible novel therapeutic targets. Total RNA was extracted from skin lesion samples from sporotrichosis patients and used to construct a long-chain RNA transcriptome library and miRNA transcriptome library for whole transcriptome sequencing. The differentially expressed genes (DEGs) between the groups were identified, and then Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and Gene Set Enrichment Analysis enrichment analyses were performed based on the DEGs. An lncRNA-miRNA-mRNA ceRNA network was constructed. The expressions of JAK/STAT pathway-related proteins were detected in the patient and control tissues using RT-qPCR and Western blot analysis. Enrichment analysis showed that the DEGs were mainly enriched in various infectious diseases and immune response-related signaling pathways. Competing endogenous RNA network analysis was performed and identified the hub lncRNAs, miRNAs, and mRNAs. Compared with the control group, the mRNA expressions of SOCS3, IL-6, and JAK3 were significantly upregulated, while the expression of STAT3 did not change significantly. Also, the protein expressions of SOCS3, IL-6, JAK3, and STAT3, as well as phosphorylated JAK3 and STAT3, were significantly upregulated. We identified 671 lncRNA DEGs, 3281 mRNA DEGs, and 214 miRNA DEGs to be involved in Sporothrix globosa infection. The study findings suggest that the JAK/STAT pathway may be a therapeutic target for sporotrichosis.
Associations between screen viewing at 2 and 3.5 years and drawing ability at 3.5 years among children from the French nationwide Elfe birth cohort
Authors: Poncet Lorraine , Saïd Mélèa , Yang Shuai , Müller-Riemenschneider Falk , Berticat Claire , Raymond Michel , Barkat-Defradas Mélissa , Charles Marie-Aline , Bernard Jonathan Y.
Published: January 2024

The effect of screen viewing on children’s cognitive development has been of concern among parents and researchers. This study investigated the association between children screen time, as reported by parents, and drawing ability, and the confounding effects of socioeconomic characteristics (such as parental education, household income, migration status) and children’s competing activities (such as drawing practice, extracurricular activity, outdoor time, sleep time, time playing with parents). Participants included 7577 children aged 3.5 years (50% girls) who underwent the Draw-a-person test (McCarthy score [range = 0–12 points]) in the French nationwide Elfe birth cohort, initiated in 2011. Sex-stratified zero-inflated Poisson regression models were used. Increased screen time was associated with a higher likelihood to obtain a null score in boys (OR 1.15, 95% CI 1.07–1.23) and girls (1.13 [1.03–1.24]) and a lower score in girls only (β =  − 0.02, 95% CI − 0.04; − 0.01). After adjusting for SES, associations were no longer observed, indicating that the association between screen time and drawing abilities was confounded by socioeconomic characteristics.
Validation of remote anthropometric measurements in a rural randomized pediatric clinical trial in primary care settings
Authors: Zhang E , Davis Ann M. , Jimenez Elizabeth Yakes , Lancaster Brittany , Serrano-Gonzalez Monica , Chang Di , Lee Jeannette , Lai Jin-Shei , Pyles Lee , VanWagoner Timothy , Darden Paul
Published: January 2024

Rural children are more at risk for childhood obesity but may have difficulty participating in pediatric weight management clinical trials if in-person visits are required. Remote assessment of height and weight observed via videoconferencing may provide a solution by improving the accuracy of self-reported data. This study aims to validate a low-cost, scalable video-assisted protocol for remote height and weight measurements in children and caregivers. Families were provided with low-cost digital scales and tape measures and a standardized protocol for remote measurements. Thirty-three caregiver and child (6–11 years old) dyads completed remote (at home) height and weight measurements while being observed by research staff via videoconferencing, as well as in-person measurements with research staff. We compared the overall and absolute mean differences in child and caregiver weight, height, body mass index (BMI), and child BMI adjusted Z-score (BMIaz) between remote and in-person measurements using paired samples t-tests and one sample t-tests, respectively. Bland–Altman plots were used to estimate the limits of agreement (LOA) and assess systematic bias. Simple regression models were used to examine associations between measurement discrepancies and sociodemographic factors and number of days between measurements. Overall mean differences in child and caregiver weight, height, BMI, and child BMIaz were not significantly different between remote and in-person measurements. LOAs were − 2.1 and 1.7 kg for child weight, − 5.2 and 4.0 cm for child height, − 1.5 and 1.7 kg/m2 for child BMI, − 0.4 and 0.5 SD for child BMIaz, − 3.0 and 2.8 kg for caregiver weight, − 2.9 and 3.9 cm for caregiver height, and − 2.1 and 1.6 kg/m2 for caregiver BMI. Absolute mean differences were significantly different between the two approaches for all measurements. Child and caregiver age were each significantly associated with differences between remote and in-person caregiver height measurements; there were no significant associations with other measurement discrepancies. Remotely observed weight and height measurements using non-research grade equipment may be a feasible and valid approach for pediatric clinical trials in rural communities. However, researchers should carefully evaluate their measurement precision requirements and intervention effect size to determine whether remote height and weight measurements suit their studies.

Trial registration: ClinicalTrials.gov NCT04142034 (29/10/2019).
2 DOF transformable wheel design based on geared 8 bar parallel linkage mechanism
Authors: Yoon Hyeungyu , Kim SangGyun , Park Inha , Heo Jaeyeong , Kim Hwa Soo , Seo TaeWon
Published: January 2024

This paper introduces a novel design and static optimization for a two-degrees-of-freedom transformable wheel based on a geared linkage mechanism. Overcoming obstacles, including stairs, with small wheels is a major challenge in the field of mobile robotics research. Among various robots, the transformable wheel, which can change the shape of the wheel to overcome steps and optimize the path, was presented and has undergone many improvements. Nevertheless, problems such as asymmetry and structural strength remain. Therefore, the design of this paper aims to address the structural inefficiencies identified in the previous research model, which were attributed to the asymmetric placement of the linear motion guide. Through the implementation of this mechanism, the linear motion of the lobe can be segregated, enabling each input motor to share the workload effectively. The optimization process focus on determining the optimal linkage length under static conditions, resulting in improved structural characteristics and force distribution of linkage within the designated workspace. As a result, asymmetry of motion is eliminated, required intervention angle of the driving motor and stress of linkage was reduced by 36.24% and 8.35%, respectively.