bluuebunny/crossref_metadata_2025 huggingface dataset:
Bronchioloalveolar lung tumors induced in “mice only” by non-genotoxic chemicals are not useful for quantitative assessment of pulmonary adenocarcinoma risk in humans
Authors: Smith Carr J , Perfetti Thomas A , King Judy A
Published: December 2018

Chemicals classified as known human carcinogens by International Agency for Research on Cancer (IARC) show a low level of concordance between rodents and humans for induction of pulmonary carcinoma. Rats and mice exposed via inhalation for 2 years show a low level of concordance in both tumor development and organ site location. In 2-year inhalation studies using rats and mice, when pulmonary tumors are seen in only male or female mice or both, but not in either sex of rat, there is a high probability that the murine pulmonary tumor has been produced via Clara cell or club cell (CC) metabolism of the inhaled chemical to a cytotoxic metabolite. Cytotoxicity-induced mitogenesis increases mutagenesis via amplification of the background mutation rate. If the chemical being tested is also negative in the Ames Salmonella mutagenicity assay, and only mouse pulmonary tumors are induced, the probability that this pulmonary tumor is not relevant to human lung cancer risk goes even higher. Mice have a larger percentage of CCs in their distal airways than rats, and a much larger percentage than in humans. The CCs of mice have a much higher concentration of metabolic enzymes capable of metabolizing xenobiotics than CCs in either rats or humans. A principal threat to validity of extrapolating from the murine model lies in the unique capacity of murine CCs to metabolize a significant spectrum of xenobiotics which in turn produces toxicants not seen in rat or human pulmonary pathophysiology.
Tubulitis in a patient treated with nivolumab: Case report and literature review
Authors: Vakil Viral , Birkenbach Mark , Woerner Katti , Bu Lihong
Published: December 2018

Kidney injury associated with use of immune checkpoint inhibitors that target the programmed death-1 molecule commonly manifests as acute tubulointerstitial nephritis on kidney biopsy. We present a case of a 66-year-old man who developed acute kidney injury at 6 months after initiation of treatment with anti-programmed death-1 antibody, nivolumab, for treatment of metastatic urothelial carcinoma. A renal biopsy showed focal moderate-to-severe lymphocytic tubulitis with minimal interstitial inflammation. Programmed death ligand-1 immunopositivity was detected only in tubules exhibiting lymphocytic tubulitis. The patient’s renal function improved to baseline with conservative management consisting of discontinuation of nivolumab followed by prednisone treatment.
Regulation of SOX11 expression through CCND1 and STAT3 in mantle cell lymphoma
Authors: Mohanty Atish , Sandoval Natalie , Phan An , Nguyen Thang V. , Chen Robert W. , Budde Elizabeth , Mei Matthew , Popplewell Leslie , Pham Lan V. , Kwak Larry W. , Weisenburger Dennis D. , Rosen Steven T. , Chan Wing C. , Müschen Markus , Ngo Vu N.
Published: December 2018

The neural transcription factor SOX11 is usually highly expressed in typical mantle cell lymphoma (MCL), but it is absent in the more indolent form of MCL. Despite being an important diagnostic marker for this hard-to-treat malignancy, the mechanisms of aberrant SOX11 expression are largely unknown. Herein, we describe 2 modes of SOX11 regulation by the cell-cycle regulator cyclin D1 (CCND1) and the signal transducer and activator of transcription 3 (STAT3). We found that ectopic expression of CCND1 in multiple human MCL cell lines resulted in increased SOX11 transcription, which correlated with increased acetylated histones H3K9 and H3K14 (H3K9/14Ac). Increased H3K9/14Ac and SOX11 expression was also observed after histone deacetylase 1 (HDAC1) or HDAC2 was depleted by RNA interference or inhibited by the HDAC inhibitor vorinostat. Mechanistically, we showed that CCND1 interacted with and sequestered HDAC1 and HDAC2 from the SOX11 locus, leading to SOX11 upregulation. Interestingly, our data revealed a potential inverse relationship between phosphorylated Y705 STAT3 and SOX11 expression in MCL cell lines, primary tumors, and patient-derived xenografts. Functionally, inactivation of STAT3 by inhibiting the upstream Janus kinase (JAK) 1 or JAK2 or by STAT3 knockdown was found to increase SOX11 expression, whereas interleukin-21 (IL-21)–induced STAT3 activation or overexpression of the constitutively active form of STAT3 decreased SOX11 expression. In addition, targeting SOX11 directly by RNA interference or indirectly by IL-21 treatment induced toxicity in SOX11+ MCL cells. Collectively, we demonstrate the involvement of CCND1 and STAT3 in the regulation of SOX11 expression, providing new insights and therapeutic implications in MCL.
The SMAC mimetic LCL-161 displays antitumor activity in preclinical models of rituximab-resistant B-cell lymphoma
Authors: Runckel Kyle , Barth Matthew J. , Mavis Cory , Gu Juan J. , Hernandez-Ilizaliturri Francisco J.
Published: December 2018

Clinical observations suggest the existence of shared resistance pathways between rituximab and chemotherapy agents. To explore the mechanisms of rituximab resistance, our group created rituximab-resistant cell lines (RRCLs), which display altered expression of several inhibitor of apoptosis (IAP) family proteins. Here, we provide evidence to support pharmacologically targeting IAPs in lymphoma with LCL-161, a small molecule mimetic of the second mitochondria-derived activator of caspases (SMAC). The antitumor effect of LCL-161 was determined using luminescent adenosine triphosphate assays, flow cytometry, SCID mouse xenografts, and ex vivo patient biopsy sample studies. In vitro exposure to LCL-161 also resulted in a dose-dependent decrease in IAP levels, along with synergistic enhancement of the antitumor effect of cytotoxic chemotherapy, in rituximab-sensitive cell lines and RRCLs. In addition, LCL-161 increased the cytotoxic effect of the proteasome inhibitor carfilzomib in ex vivo lymphoma patient samples. The combination of LCL-161 with the chemotherapy regimen rituximab, gemcitabine, and vinorelbine (RGV) improved in vivo survival compared with RGV alone in severe combined immunodeficient mice implanted with RRCLs but not in animals implanted with rituximab-sensitive cell lines. In summary, LCL-161 exhibits synergistic antitumor activity in both in vitro and in vivo models of resistant lymphoma. Our data support further preclinical investigation of LCL-161 as a novel antilymphoma agent.
O vendedor na disrupção digital
Authors: Do Prado Lucas Sciencia , Guissoni Leandro Angotti , Kehdi Marco Tulio
Published: December 2018

Com a virtualização das forças de vendas, as atividades de prospectar clientes, trabalhar valor, fechar negócio e manter suporte vêm se transformando.
Imposto pode ser investimento?
Authors: Sandroni Paulo
Published: December 2018

Se o imposto sobre os mais ricos ajudar a economia, os dividendos crescem, compensando (até com acréscimos) o tributo pago.
Recent advances in managing benign prostatic hyperplasia: The Rezūm System
Authors: Guelce Dominique , Thomas Dominique , Elterman Dean , Chughtai Bilal
Published: December 2018

Benign Prostatic Hyperplasia is a common condition that affects 50% of men in their 50th decade. There have been many advances in the treatment of this condition, which aim to improve the patient’s quality of life. A new treatment that shows promising results is the Rezūm System, a water vapor therapy for BPH. We present the most current literature on this therapy.
Drinking vessel preferences in older nursing home residents: optimal design and potential for increasing fluid intake
Authors: Bak Aggie , Wilson Jennie , Tsiami Amalia , Loveday Heather
Published: December 2018

Background:

residents in nursing and residential care homes are at risk of dehydration due to both resident and institutional factors. Previous studies have focused on improving fluid intakes by concentrating on types of fluids offered and assisting residents to drink.

Aim:

to determine resident opinion of the optimal features of drinking vessels and evaluate the impact of improving vessel design on fluid consumption.

Methods:

residents from two units (25-bed and 21-bed) in one nursing home evaluated a range of drinking vessels. Vessels with preferred features were introduced on a 25-bed unit. The effect was tested by observing residents' fluid consumption during breakfast on three consecutive days and comparing with baseline intakes.

Findings:

vessels that received the highest ratings were lightweight, had large handles and held 200–300 ml of fluid. Following the introduction of the new drinking vessels, mean fluid intakes at breakfast increased from 139 ml (±84 ml) to 205 ml (±12 ml, n=65), p=0.003.

Conclusion:

some drinking vessels used in nursing homes may be difficult for residents to handle. Making improvements to the design of drinking vessels has the potential to increase fluid intakes without increasing staff workload.
Urinary catheters: PART 2 Catheterisation in males and females
Authors: Mitchell Michelle , Hill Barry
Published: December 2018

Michelle Mitchell, Graduate Tutor for Adult Nursing, Northumbria University, michelle3.mitchell@northumbria.ac.uk and Barry Hill, Senior Lecturer in Adult Nursing, Northumbria University, describe the different catheterisation needs of men and women and the procedures to follow
Collaborating with the carers of dementia patients in the acute setting
Authors: Mendes Aysha
Published: December 2018

Aysha Mendes, Freelance Journalist, specialising in health, psychology and nursing, discusses how nurses can build positive relationships with the carers of people with dementia
Protecting healthcare staff from abuse: tackling workplace incivility in nursing
Authors: Glasper Alan
Published: December 2018

Emeritus Professor Alan Glasper, from the University of Southampton, discusses polices and strategies used to tackle bullying and incivility within nursing
Poor communication and an opaque complaints process
Authors: Tingle John
Published: December 2018

John Tingle discusses a recent report commissioned by NHS Resolution on what motivates patients to sue the NHS when things go wrong with their care and treatment
Research roundup: December 2018
Authors: Som Rita
Published: December 2018

In brief

Updated and expanded review offers new insights into primary care prescribing decisions for acute respiratory tract infections Cancer treatments accelerate biological ageing associated with cognitive function in breast cancer survivors Influenza vaccination study results support existing data on waning effects
Non-medical prescribing leads conference
Authors: Peniston-Bird Fiona
Published: December 2018

The national non-medical prescribing leads conference was held on 1 November in Gatwick. Here, Fiona Peniston-Bird reports on highlights from the day
6-8. Sınıf Üstün Yetenekli Öğrencilerin Problem Çözerken Sergiledikleri Üst Bilişsel Beceriler: Gümüşhane Örneği
Authors: ÖZTÜRK Mesut , AKKAN Yaşar , KAPLAN Abdullah
Published: December 2018

Üstün yetenekli öğrencilerin üst bilişsel becerilerini kullanarak problem çözmeleri, öğrencilerin matematik kavramlarına yönelik ilişki kurmasını güçlendirerek, matematiksel anlamalarını ve matematiği derinlemesine öğrenmelerini geliştirecektir. Bu nedenle çalışmanın amacı 6-8. sınıf üstün yetenekli öğrencilerin problem çözerken sergiledikleri üst bilişsel becerileri belirlemek ve karşılaştırmaktır. Çalışmada nitel araştırma desenlerinden durum çalışması yöntemi kullanılmıştır. Üstün yetenekli dokuz ortaokul öğrencisiyle yürütülen bu çalışmada veriler, sesli düşünme protokolü (görüşme formları) ve gözlem formları kullanılarak toplanmıştır. Alan yazıdaki çalışmalardan yararlanılarak tematik analiz yapılmıştır. Çalışmanın sonucunda farklı öğrenim seviyesindeki üstün yetenekli öğrencilerin problem çözme basamaklarının tamamında üst bilişsel beceri sergiledikleri,  öğrencilerin öğrenim seviyesi arttıkça problem çözme süreçlerinde sergiledikleri üst bilişsel becerilerin sayısının genel olarak arttığı belirlenmiştir. Bunula birlikte problem çözme basamaklarının tümünde öğrencilerin genel olarak kendilerine güvendikleri, hedeflerini (tekrar) gözden geçirdikleri ve her basamakta kendilerini değerlendirdikleri/kontrol ettikleri tespit edilmiştir.
A liderança em contexto educativo: validação da escala ética, transformacional e moral
Authors: Neves Lurdes , Coimbra Joaquim Luís
Published: December 2018

O conceito de liderança tem sido alvo de análise e estudo, particularmente no contexto organizacional. Existe bastante complexidade em definir a liderança resultando num conjunto vasto de definições, contudo, existe alguma confluência na representação da liderança enquanto o processo de influência exercido como forma de atingir determinados objetivos. O presente estudo teve como objetivos: realizar a validação das escalas de Liderança ética, moral e transformacional em contexto educativo. Numa amostra de 204 professores foi possível verificar o comportamento dos três questionários ao nível da validade de constructo e da fiabilidade. As escalas de Liderança avaliadas (ética, transformacional e moral) apresentaram bons níveis de ajustamento à estrutura fatorial e valores de fiabilidade entre aceitável e excelente.
Impacto do estilo de vida na adaptação individual e relacional e nos resultados obstétricos de mulheres adultas após o parto
Authors: Levandowski Daniela Centenaro , Pereira Marco , Moura­‑Ramos Mariana , Canavarro Maria Cristina
Published: December 2018

O objetivo deste estudo foi analisar e comparar retrospetivamente o estilo de vida (EV) de mulheres antes e durante a gravidez; descrever a adaptação individual e relacional na transição para a maternidade e os resultados obstétricos; e avaliar a associação entre hábitos de EV e estes indicadores. A amostra foi composta por 98 mães, a maioria casadas ou em união de facto, com ensino secundário ou superior, nulíparas e que planearam a gravidez. A bateria de avaliação incluiu um questionário sociodemográfico, a Escala de Avaliação das Emoções, o Inventário de Sintomas Psicopatológicos e escalas de adjetivos para avaliar os domínios conjugal e parental. Os resultados mostraram uma mudança positiva no EV durante a gravidez em comparação ao período precedente. Foi encontrada uma associação significativa entre a adoção de hábitos de vida saudáveis e menor sintomatologia psicopatológica e maior reatividade emocional positiva. Estes resultados salientam a importância da avaliação de diferentes componentes do EV e a sua associação com diversos indicadores individuais e relacionais para uma melhor compreensão da adaptação das mulheres na transição para a maternidade.
Baixa produtividade: Afetação de recursos e obstáculos ao crescimento das empresas na economia portuguesa
Authors: Rocha Bruno T.
Published: December 2018

Existe em diversos setores da economia portuguesa uma concentração elevada de recursos em microempresas, sendo que as mesmas apresentam, em média, níveis de produtividade baixos. Tal afetação de recursos reflete‑se negativamente na produtividade agregada da economia. Este artigo começa por apresentar alguns dados que ilustram esta realidade, alicerçando‑se na literatura económica para, seguidamente, discutir fatores que podem desincentivaro crescimento das empresas e, deste modo, dificultar a absorção de recursos por parte das empresas relativamente mais produtivas. Destacam‑se entre estes a existência de regras e políticas públicas aplicáveis apenas a empresas abaixo de determinados patamares de dimensão, o funcionamento do sistema de justiça e o reduzido nível de formação dos gestores.
El turismo y el alivio de la pobreza: un enfoque desde el prisma de los destinos emergentes en el marco de la Agenda 2030
Authors: Puig-Cabrera Miguel , Foronda-Robles Concepción
Published: December 2018

El turismo es señalado como un sector clave para la consecución de los Objetivos de Desarrollo Sostenible (ODS). Los beneficios que reporta esta actividad en los destinos tradicionales son incuestionables. No obstante, desde el prisma de los destinos emergentes, las garantías no están aseguradas. El propósito principal de este trabajo es analizar la potencialidad del turismo en los destinos emergentes y sus efectos en el desarrollo socioeconómico, de cara a la Agenda 2030. Se han formulado diversas hipótesis para ser contrastadas en 152 destinos emergentes, buscando un acercamiento a la realidad de estos países desde el turismo y su contribución al desarrollo socioeconómico de la población. Se incluyen 43 de los 48 Países Menos Adelantados (PMA), caracterizados por tener el turismo como una de sus principales fuentes de exportación. La metodología utilizada se basa en un análisis cuatridimensional, a partir de variables macroeconómicas que consideran: 1) las condiciones de pobreza y desigualdad del territorio; 2) el nivel de desarrollo turístico; 3) el compromiso de las administraciones públicas con el turismo y 4) el acceso directo por parte de la población hacia los beneficios que reporta el turismo en el territorio. El método de contraste seguido para validar las hipótesis iniciales ha sido a través del coeficiente de correlación de Pearson. Los resultados de este trabajo ponen en entredicho si el desarrollo turístico es la causa del desarrollo en un destino, o, por el contrario, el desencadenante de su subdesarrollo.
Attracting visitors to ancient neighbourhoods: creation and management of the tourist-historic city of Plymouth, UK. Groningen: InPlanning, 2016. Dr. Daniel Barrera-Fernández / 293 páginas
Authors: Hernández-Gómez Aranza
Published: December 2018

Reseña del libro: Barrera-Fernández, Daniel (2016). Attracting visitors to ancient neighbourhoods. Creation and management of the historic city of Plymouth, UK. In Planning. ISBN 978-94-91937-19-4, 289 pp.
Las estrategias de seguridad de la Unión Europea (2003, 2016): contexto político, cambios esenciales y evolución de las prioridades políticas europeas relativas a África en materia de seguridad
Authors: Alaminos Hervás María Ángeles
Published: December 2018

En el presente artículo, examinamos los cambios más significativos existentes en el planteamiento y la formulación de las dos estrategias de seguridad de la Unión Europea, presentadas en 2003 y 2016, lo cual nos permite abordar cuestiones fundamentales relativas a la evolución de la política exterior y de seguridad de la Unión Europea desde el comienzo del nuevo milenio, analizando en particular las implicaciones para el continente africano. Por un lado, el análisis de los elementos centrales de las dos estrategias nos permite observar un cambio de rumbo y una redefinición de la política exterior y de seguridad de la UE, desde presupuestos normativos hasta nuevas aproximaciones más centradas en los objetivos e intereses propios de Europa. Por otro lado, podemos también observar la evolución de las prioridades de la Unión Europea en lo que respecta a su aproximación al continente africano. En este sentido, en lugar de abordar los diferentes ámbitos de interés mutuo, las relaciones UE-África se enmarcan en un enfoque limitado de política exterior centrado de manera preponderante en los asuntos de seguridad en África.
Focus 2 - décembre 2012
Authors: Hindriks Jean
Published: December 2018

A l'instar de beaucoup de pays européens, nous vivons une crise budgétaire sans précédent avec une perte progressive de contrôle de nos finances publiques sous la forme d'un double effet boule de neige.
Focus 4 - décembre 2012
Authors: Belleflamme Paul
Published: December 2018

Depuis le 1er octobre dernier, une nouvelle loi «Télécom» transpose dans le droit belge une série de directives européennes visant à mieux protéger les consommateurs sur le marché des télécommunications. Une des mesures phares de cette loi est la possibilité qui est désormais donnée aux consommateurs de changer d'opérateur (téléphonie fixe ou mobile, Internet et télévision) sans frais après seulement six mois de contrat. Une autre mesure consiste à faciliter la comparaison entre les offres tarifaires des différents opérateurs (ainsi, pour ce qui est de l'Internet, les opérateurs doivent désormais afficher la vitesse de connexion réelle et non plus maximale comme auparavant).
Focus 10 - juin 2013
Authors: Belleflamme Paul
Published: December 2018

Cela fait quelques jours que l'on commente en tous sens l'annonce par Walibi de la création d'un "Speedy Pass" permettant, pour un prix de 35 €, de couper les files d'attente. En particulier, Philippe Courard (Secrétaire d'Etat aux Familles) et Bruno Vanobbergen (Commissaire flamand aux droits de la jeunesse) ont dénoncé une politique tarifaire faisant la différence entre enfants riches et pauvres. L'objet de ce focus est d'éclairer le débat en expliquant quelques principes économiques sous-jacents.
Focus 12 - février 2014
Authors: Mayneris Florian
Published: December 2018

Afin de redynamiser la zone du Canal, caractérisée par un taux de chômage élevé et un faible revenu de ses résidents, le gouvernement bruxellois a décidé d'offrir des incitants financiers aux entreprises venant s'y installer : extension des aides à l'investissement (la Région bruxelloise pouvant prendre en charge jusqu'à 35 % du coût de ces investissements), aides à l'embauche (avec des subventions pouvant aller jusqu'à 30 % du salaire brut) et, enfin, exemption partielle de la taxe sur les surfaces de bureau (taxe communale pesant sur les entreprises industrielles, commerciales et agricoles). Pour bénéficier de ces aides, les entreprises doivent toutefois respecter une «clause d'embauche locale» : 30 % de leur personnel doit résider dans la zone d'économie urbaine stimulée (ZEUS), qui couvrira plusieurs quartiers le long du Canal, d'Anderlecht à Schaerbeek.
Focus 13 - octobre 2014
Authors: Baert Stijn , Omey Eddy
Published: December 2018

Tout comme les pays scandinaves et l'Autriche, la Belgique connait un taux de syndicalisation assez élevé. Un peu plus de 50 % des salariés belges sont membres d'un syndicat (http://www.uva-aias.net/208). Par ailleurs, le niveau de syndicalisation est plus élevé parmi les salariés jeunes et âgés que parmi ceux d'un âge intermédiaire (Van Rie et al., 2011). Plus important encore, le taux de couverture, à savoir la fraction des salariés dont les conditions d'emploi sont régies par une convention collective de travail, est de l'ordre de 90 % en Belgique (http://www.uva-aias.net/208). Enfin, dans notre pays, les syndicats gardent un rôle important dans l'octroi des allocations de chômage (Van Rie et al., 2011). De ce fait, les syndicats constituent un acteur incontournable sur le marché du travail belge.
Focus 15 - décembre 2014
Authors: Bréchet Thierry
Published: December 2018

Il y a peu, la presse s'est faite l'écho d'une étude réalisée pour la Commission européenne sur le coût de la production d'électricité par différentes technologies (voir le communiqué de presse de la Commission; l'étude est accessible ici). Cette étude comparait la production par le nucléaire, le gaz, le charbon, l'éolien terrestre, l'éolien en mer et le solaire. Elle présentait le coût de production en tant que tel (le coût privé), le coût externe (le coût pour la collectivité lié à la pollution), et le coût des subventions publiques.
Focus 17 - juillet 2015
Authors: Hindriks Jean
Published: December 2018

En 1930, John Maynard Keynes écrivait : «Nos petits-enfants n’auront pas assez de travail. Ils vont devoir se répartir au maximum le travail disponible. Instaurer des semaines de 15 heures avec postes de trois heures par jour permettra de résoudre le problème. Travailler trois heures par jour sera amplement suffisant».
Focus 18 - avril 2016
Authors: Belleflamme Paul , Toulemonde Eric
Published: December 2018

Dans son communiqué de presse du 9 avril 2016 relatif au contrôle budgétaire, le gouvernement belge annonce, parmi les réformes structurelles, la taxation de ce qu’il est convenu d’appeler l’économie collaborative, dont les figures emblématiques sont des plateformes numériques comme Airbnb, Uber ou Listminut. Le communiqué n’indique pas la manière dont cette taxation serait réalisée mais selon Le Soir et Trends, le cabinet du Ministre De Croo envisagerait d’opérer des prélèvements à la source sur les revenus que les prestataires (les hôtes d’Airbnb, les conducteurs d’Uber, …) gagnent sur ces plateformes.
Focus 20 - décembre 2016
Authors: Van der Linden Bruno
Published: December 2018

Selon les projections économiques de l’automne 2016 réalisées par la BNB, l’emploi en Belgique a augmenté de 116.000 unités sur la période 2014-2016. Le gouvernement fédéral s’est empressé d’y voir une illustration du succès de sa politique. Ce que notamment l’Institut pour un développement durable a «mis en perspective».

Se faire une opinion quant au lien entre l’action de tel gouvernement et nos performances d’emploi est un exercice critiquable si l’évolution observée n’est pas comparée à la construction d’une situation de référence de qualité. Celle-ci doit mesurer ce qu’il serait advenu à l’emploi chez nous en l’absence de l’action du gouvernement concerné. La construction de cette situation de référence est indispensable. Elle est aussi un défi, souvent mal relevé.
Focus 22 - septembre 2018
Authors: Cockx Bart , Decoster André , Dejemeppe Muriel , Spinnewijn Johannes , Van der Linden Bruno
Published: December 2018

Des allocations de chômage plus élevées au cours des six premiers mois. Dans les mois suivants un déclin plus rapide. C'est ce que le gouvernement fédéral a décidé dans le «jobs deal» de cet été. Par cette réforme le gouvernement entend encourager les personnes sans emploi à rechercher plus activement du travail et à accepter plus vite une offre d’embauche. Le gouvernement brandit des arguments scientifiques pour justifier une dégressivité plus rapide. Mais y a-t-il un consensus scientifique à ce sujet ? Nous ne le pensons pas. En outre, nous considérons que ce volet du deal porte atteinte à une des principales missions de l’assurance-chômage.
Performance Analysis and Ranking of Corporate Medical Institutions in India
Authors: Nanda Susama , Mishra Manoj , Ramesh Dola Babu
Published: December 2018

Health science research focuses to generate new knowledge through new technique, research design and organisational interventions to serve the whole community. The corporate Medical colleges are determined to establish themselves in both academic and research purpose. The performance index (P-index) is an interesting parameter to calculate the ranking performance of any institution. This study presents an analysis of the research growth, collaboration of researchers with ranking of the corporate medical institutes in India according to p-index.
Information Access Mechanism for Visually Impaired Students in Higher Education Institutions in Delhi: A Study
Authors: Bhardwaj Raj Kumar
Published: December 2018

The present study identified information access mechanisms for visually impaired students in select universities in Delhi, India. Study has ascertained the availability of information and communication technology (ICT) infrastructure in five major universities. The study applied purposive sampling method and collected data through a questionnaire from select universities. It was found that facilities for visually impaired students in higher educational institutions are very basic and it is difficult for visually impaired students to conduct study and research with existing ICT infrastructure. Higher educational institutions in Delhi do not have the infrastructure suited to the needs of visually impaired students to facilitate efficient services. University libraries in Delhi are facing difficulties due to lack of funds and trained staff to deliver services to visually impaired students. Library and information science professionals face inhibits in providing services to visually impaired students because of lack of suitable equipment(s), ‘maintenance/updating of assistive software(s) and devices, time consuming scanning process and lack of awareness among visually impaired students about library resources and services.
Fuzzy Logic-based Adaptive Extended Kalman Filter Algorithm for GNSS Receivers
Authors: Sreeharsha Pasumarthi Babu , Devanaboyina Venkata Ratnam
Published: December 2018

Designing robust carrier tracking algorithms that are operable in strident environmental conditions for global navigation satellite systems (GNSS) receivers is the discern task. Major contribution in weakening the GNSS signals are ionospheric scintillations. The effect of scintillation can be known by amplitude scintillation index S4 and phase scintillation index sf parameters. The proposed fuzzy logic based adaptive extended Kalman filter (AEKF) method helps in modelling the signal amplitude and phase dynamically by Auto-Regressive Exogenous (ARX) analysis using Sugeno fuzzy logic inference system. The algorithm gave good performance evaluation for synthetic Cornell scintillation monitor (CSM) data and real-time strong scintillated PRN 12 L1 C/A data on October 24th, 2012 around 21:30 h, Brazil local time collected by GNSS software navigation receiver (GSNR’x). Fuzzy logic algorithm is implemented for selecting the ARX orders based on estimated amplitude and phase ionospheric scintillation observations. Fuzzy based AEKF algorithm has the capability to mitigate ionospheric scintillations under both geomagnetic quiet and disturbed conditions.
Numerical Investigations on Wedge Control of Separation of a Missile from an Aircraft
Authors: Zhu Shiquan , Huang Zhengui , Gou Yongjie , Tang Qizhong , Chen Zhihua
Published: December 2018

To make the missile safely separate from the internal weapons bay, a wedge flow control device is mounted on the front of the bay to control the variation of flow during the separation. The numerical simulations of missile separation without and with wedge flow control device under different sizes are carried out. The flow fields of different separation processes are obtained and discussed; the aerodynamic parameters and trajectory parameters of missile of different cases are illustrated and compared. Results show that, the wedge flow control device can accelerate the missile separation and has the effect of regulating the angular motion of missile. The influence of the wedge height is stronger than that of its length on the center of gravity motion and angular motion of missile.
Internet of Things Controlled Reconfigurable Antenna for RF Harvesting
Authors: Vijayan Arun , LR Karl Marx
Published: December 2018

Internet of Things (IoT) controlled a reconfigurable antenna with PIN diode switch for modern wireless communication is designed and implemented. Direct contact of biasing network with the antenna is eliminated and the switching unit is manipulated through IoT method. The proposed antenna has ring structures, in which the outer ring connects the inner ring structure through a PIN diode switch. The dimension of the proposed antenna is reported as 50 mm × 50 mm and its prototype has been made-up on epoxy-Fr4 substrate with 1.6 mm thickness. This antenna setup is made to reconfigurable in four bands (4.5 GHz, 3.5 GHz, 2.4 GHz, and 1.8 GHz) through switching provided by IoT device (NodeMCU). The antenna has a good return loss greater than -10dB.In switching state 2 the antenna has a return loss of -30 dB peak is attained at 3.4 GHz of operating frequency. Similarly the gain response of antenna is good in its operating bands of all switching states and obtained a maximum gain of 2.7 dB in 3.5 GHz. Bidirectional radiation pattern is obtained in all switching states of the antenna.
Cellulolytic yeast from gastrointestinal tract of muscovy duck (Anas moscata) as probiotic candidate
Authors: Anggraeni A.S. , Istiqomah L. , Damayanti E. , Anwar M. , Sakti A.A. , Karimy M.F.
Published: December 2018

Cellulose is one of limiting factors in local poultry feed. Yeast exploration of local poultry gastrointestinal tract and its utilization as a probiotic candidate has not been widely studying. A total of 112 isolates of yeast were obtained from the digestive tract of Muscovy Duck, Javanesse Duck and Indonesian Native Chicken in the small intestine, cecum, and colon. Yeast with cellulolytic activity was quantitatively selected using CYG agar + 1% CMC medium with an incubation time of 30 ° C for 48 hours under anaerobic conditions. A total of 107 isolates of yeasts have cellulolytic activity. M41 yeast isolates of Mentok cecum possess highest clear zones cellulolytic activity (0.64 cm). M41 yeast characterization includes molecular identification, growth ability testing in CMC and glucose combination medium, CMCase activity, and viability test of probiotic ability with time variation. The results showed that yeast M41 had 98% proximity with Saccharomyces cerevisiae based on 26S sRNA gene sequence analysis, optimum growth on medium containing 1% CMC and 0.1% glucose (b / v), CMCase activity of 42.98 U / mL, and has a viability of 91.91; 66.22; 42.00; 42.00; 1.83 and 42.13 (%) respectively on bile salts 2 hours and 3 hours, gastric juice 45 minutes and 2 hours, pH 2 and pH 3 for 90 minutes. Based on results of the study, it was concluded that S. cerevisiae M41 potentially as a probiotic candidate for poultry with cellulolytic activity.
Point-of-care haemostasis monitoring during liver transplantation is cost effective
Authors: Leon-Justel Antonio , Alvarez-Rios Ana I. , Noval-Padillo Jose A. , Gomez-Bravo Miguel A. , Porras Manuel , Gomez-Sosa Laura , Lopez-Romero Juan L. , Guerrero Juan M.
Published: December 2018

Background

Optimal haemostasis management in orthotropic liver transplant (OLT) could reduce blood loss and transfusion volume, improve patient outcomes and reduce cost.

Methods

We performed a study including 336 OLTs to evaluate the clinical and cost effectiveness of a new point-of-care (POC)-based haemostatic management approach in OLT patients.

Results

In terms of health benefit we found that the new approach showed a significant reduction in transfusion requirements (red blood cell transfusion units were reduced from 5.3±4.6 to 2.8±2.9 [p<0.001], free frozen plasma from 3.1±3.3 to 0.4±1.0 [p<0.001] and platelets from 2.9±3.9 to 0.4±0.9 [p<0.001], transfusion avoidance, 9.7% vs. 29.1% [p<0.001] and massive transfusion, 14.5% vs. 3.8% [p=0.001]); we also found a significant improvement in patient outcomes, such, reoperation for bleeding or acute-kidney-failure (8.3% vs. 2.4%, p=0.015; 33.6% vs. 5.4%, p<0.001), with a significant reduction in the length of the hospital total stay (40.6±13.8 days vs. 38.2±14.4 days, p=0.001). The lowest cost incurred was observed with the new approach (€73,038.80 vs. €158,912.90) with significant patient saving associated to transfusion avoidance (€1278.36), ICU-stay (€3037.26), total-stay (€3800.76) and reoperation for bleeding (€80,899.64).

Conclusions

POC haemostatic monitoring during OLT is cost effective.
Gallego Hernández, D. (ed.) (2015). Special Issue: New insights into specialized translation. Intralinea
Authors: Alcalde Peñalver Elena
Published: December 2018

Gallego Hernández, D. (ed.) (2015). Special Issue: New insights into specialized translation. Intralinea
La actividad de los partidos políticos españoles en Facebook 2014-2018: la tiranía del algoritmo / The activity of Spanish political parties on Facebook 2014-2018: the tyranny of the algorithm
Authors: Martínez Rolán Xabier
Published: December 2018

La principal red social del mundo, Facebook, también es el escenario del debate político digital. Pese a no tener la fuerza de Twitter, su masiva implantación convierte a esta plataforma en un canal idóneo para llegar a un público de masas en prácticamente todo el mundo, en un contexto de ciberpolítica afianzado en las sociedades occidentales. La investigación llevada a cabo, analiza la tipología de las publicaciones e interacciones recibidas en las páginas de Facebook de los cinco principales partidos políticos españoles (Partido Popular, Partido Socialista Obrero Español, Ciudadanos, Podemos e Izquierda Unida) a lo largo de los años 2014-2018. Un análisis descriptivo y longitudinal que explora la apropiación de la plataforma por parte de los diferentes actores políticos a lo largo de 12.468 publicaciones, su relación con la audiencia y con el algoritmo que controla la red social.
Las habilidades sociales en el rendimiento académico en adolescentes / Social skills in academic performance in teens
Authors: Núñez Hernández Corina Elizabeth , Hernández del Salto Víctor Segundo , Jerez Camino Daniel Sebastián , Rivera Flores Danny Gonzalo , Núñez Espinoza Marcelo Wilfrido
Published: December 2018

El comportamiento prosocial juega un papel importante en el rendimiento académico de los adolescentes. Este tipo de comportamiento tiene un impacto positivo tanto en la autovaloración como en la valoración de los demás, lo que contribuye, a su vez, a que el adolescente se sienta motivado a actuar de modo prosocial. Mediante el cumplimiento de los objetivos, se logró describir las habilidades sociales de los adolescentes escolarizados y analizar indicadores del comportamiento prosocial en los adolescentes. Se aplicó a los adolescentes un cuestionario estructurado y validado con el Alfa de Crombash. La aproximación del problema se hizo mediante la investigación cualitativa-descriptiva, la cual busca determinar la incidencia de las variables. Mediante la comprobación de la hipótesis se obtiene un juicio de valor para llegar a las conclusiones que permiten plantear una propuesta que integra la formación de los estudiantes como seres biopsicosociales. Los comportamientos sociales permitieron que se conozcan el desarrollo de experiencias de intervención en el contexto educativo, la identificación de habilidades sociales con sus pares y docentes para la promoción de sus comportamientos.
Mainstream hollywoodense en los Andes Ecuatorianos / Hollywood mainstream in the Ecuadorian Andes
Authors: Jiménez Sánchez Álvaro , Medina Guerra Franklin Nectario , Martínez Bonilla Carlos Alberto , Lavín de la Cavada José María
Published: December 2018

La industria cultural cinematográfica estadounidense lleva décadas de hegemonía mundial. El mainstream hollywoodense afecta a las salas de cine, televisión y actualmente a los contenidos a la carta gracias al auge de las plataformas en streaming. Esta investigación trata de comprobar hasta qué punto la influencia norteamericana afecta a países con grandes diferencias socio-culturales como Ecuador. Se analizan los gustos audiovisuales y los hábitos de consumo pertenecientes a la población andina del centro del país. La muestra está formada por 426 encuestados de diferentes edades y ocupaciones en el ámbito universitario. Las cuestiones planteadas tratan de conocer los contenidos audiovisuales preferidos por la audiencia (películas, series, actores, etc.) y los diferentes hábitos de consumo (frecuencia al cine, lugar ideal, número de películas, etc). Tras contrastar las respuestas, se observan diferentes patrones en el consumo audiovisual, así como una enorme influencia del cine estadounidense en el imaginario colectivo del público analizado. Finalmente, se profundiza sobre las consecuencias de los resultados a la vez que se proponen diversas aportaciones al respecto.
Hard Decisions Shape the Neural Coding of Preferences
Authors: Voigt Katharina , Murawski Carsten , Speer Sebastian , Bode Stefan
Published: December 2018

Hard decisions between equally valued alternatives can result in preference changes, meaning that subsequent valuations for chosen items increase and decrease for rejected items. Previous research suggests that this phenomenon is a consequence of cognitive dissonance reduction after the decision, induced by the mismatch between initial preferences and decision outcomes. In contrast, this functional magnetic resonance imaging and eye-tracking study with male and female human participants found that preferences are already updated online during the process of decision-making. Preference changes were predicted from activity in left dorsolateral prefrontal cortex and precuneus while making hard decisions. Fixation durations during this phase predicted both choice outcomes and subsequent preference changes. These preference adjustments became behaviorally relevant only for choices that were remembered and were in turn associated with hippocampus activity. Our results suggest that preferences evolve dynamically as decisions arise, potentially as a mechanism to prevent stalemate situations in underdetermined decision scenarios.

SIGNIFICANCE STATEMENTMost theories of decision-making assume that we always choose the best option available, based on a set of stable preferences. However, what happens for hard decisions when the available options are preferred equally? We show that in such stalemate situations, decision-makers adjust their preferences dynamically during the process of decision-making, and these preference adjustments are predicted by a left prefrontal-parietal network. We also show that eye movements during decision-making are predictive of the magnitude of the upcoming value change. Our results suggest that preferences are dynamic, adjusted every time a hard decision is made, prompting a re-evaluation of existing frameworks of decision-making.
Sınıf II Aktivatör İle Tedavi Edilmiş Bireylerde Havayolu Değişikliklerinin İncelenmesi
Authors: Sayar Gülşilay , Kılınç Delal Dara
Published: December 2018

Amaç: Bu
çalışmanın amacı fonksiyonel ortopedik tedavi gören bireylerde Andresen
aktivatörünün  havayolu üzerine etkisini
kontrol grubu ile karşılaştırmalı olarak değerlendirmektir.

Gereç ve Yöntemler:Çalışmaya
büyümesi devam eden  iskeletsel Sınıf II
maloklüzyona sahip aktivatör ile tedavi edilen 19 birey tedavi grubu, sabit
fonksiyonel ortopedik tedavi öncesi ortodontik tedavisi yapılacak ve
gözlenmekte olan 19 adet iskeletsel Sınıf II birey kontrol grubu olarak
katılmıştır. Bu hastalardan elde edilen lateral sefalometrik filmler üzerinde
ölçümler gerçekleştirilmiştir. Normal dağılım gösteren verilerin
karşılaştırılmasında bağımsız örnek t testi ile eşli örnek t testi kullanıldı.
Normal dağılım göstermeyen verilerin karşılaştırılmasında ise Mann Whitney U
testi kullanıdı.  Anlamlılık düzeyi
p<0,05 olarak alındı.

Sonuçlar:Aktivatör
kullanımı ile üst ve alt havayolunda tedavi öncesi ile tedavi sonrası arasında
anlamlı artış bulunmasına rağmen, kontrol grubu ile aralarında anlamlı
farklılık bulunmamıştır.

Anahtar Kelimeler:Aktivatör,
Sınıf II maloklüzyon, Ortodonti, Havayolu
LA DIALÉCTICA MARXISTA Y EL HUMANISMO DE LA PRAXI
Authors: Hinkelammert Franz
Published: December 2018

En el presente artículo, el autor se ocupa de mostrar aspectos del pensamiento de Marx, partiendo de sus propios escritos, para subrayar su racionalidad de la acción económica y política, contraria a la racionalidad del mercado. Con ella, Marx reivindica la humanidad del ser humano como criterio central para el propio ser humano. Que el ser humano sea el ser supremo para el ser humano es, según Marx, un imperativo categórico. Marx busca lo que el autor llama un humanismo de la praxis, que parece ser el núcleo de su dialéctica trascendental, y no simplemente dialéctica hegeliana. Esto resulta muy pertinente hoy, con- sidera el autor, ya que el neoliberalismo ha traído una forma extrema de interpretación del capitalismo, nunca dada en la historia, que implica la extrema abolición de lo humano. El objetivo del autor es aportar a pensar una alternativa para el destructivo capitalismo actual.
FRACTURAS SOCIALES Y CLAROSCUROS IDEOLÓGICOS: COSTA RICA EN EL SEGUNDO GOBIERNO DE ACCIÓN CIUDADANA
Authors: Morales Gamboa Abelardo
Published: December 2018

El inicio del segundo mandato del Partido Acción Ciudadana, en el gobierno de Costa Rica, está precedido por significativos cambios. En este artículo nos aproximaremos a tres aspectos: primero, los efectos, sobre la sociedad, de la interrelación entre la economía local y la transnacionalización de los capitales; segundo, los vacíos asociado a la crisis del pensa- miento ideológico y la continuidad del conservadurismo; y, finalmente, la declinación del papel estabilizador de las capas medias en lo social y en lo político. En esa correlación de factores, se analiza el debilitamiento de la sociedad civil y las fracturas sociales, políticas, culturales y territoriales que fraccionan a Costa Rica en sociedades muy desiguales. El trasfondo de estos reacomodos no es solo económico y político sino ideológico; se afianza el neoliberalismo como complejo de doctrinas que guían la lógica económica, pero también la adhesión de esas creaciones a elaboraciones ideológicas que condicionan las sensibilidades colectivas (deterioro de la cohesión social, desafección con las instituciones y reencanta- miento mesiánico de las masas).
RESEÑA DEL LIBRO HEGEMONÍA Y DEMOCRACIA EN DISPUTA. TRUMP Y LA GEOPOLÍTICA DEL NEOCONSERVADURISMO, DE MARCO A. GANDÁSEGUI Y JAIME ANTONIO PRECIADO CORONADO (COORDINADORES) (2017)1
Authors: Capera Figueroa José Javier
Published: December 2018

En este apartado se ofrece una reseña del libro HEGEMONÍA Y DEMOCRACIA EN DISPUTA. TRUMP Y LA GEOPOLÍTICA DEL NEOCONSERVADURISMO, de Marco A. Gandásegui y Jaime Antonio Preciado Coronado (coord.), publicado en el ano 2017.
Three-Photon Resonance Ionization Spectroscopy of Excited Even-Parity States of the Samarium Atom
Authors: Gomonai A. I. , Gomonai A. N.
Published: December 2018

Excited even-parity states of the samarium atom in the energy interval 32620–34092 cm−1 have been studied by using single-color three-photon resonance ionization spectroscopy. The energies and total angular momenta of 72 states were determined. Nine new levels were revealed.
Nature of Self-Diffusion in Fluids
Authors: Malomuzh M. P.
Published: December 2018

The nature of the self-diffusion in low-molecular fluids is discussed. The particular attention is paid to atomic fluids (such as argon), liquid metals, and associated fluids (such as water). The self-diffusion coefficient in the fluids of all indicated types is considered to be the sum of two components: one of them is associated with the transfer of molecules by hydrodynamic vortex modes, and the other is generated by the circulatory motion of local molecular groups. The both components have a collective nature, they are genetically related to each other and differ only by their scales: the former is mesoscopic, the latter is nanoscopic. Manifestations of the collective vortical transport of molecules as specific features in the time dependence of the root-mean-square displacement of molecules are discussed. Sound arguments are proposed concerning the inadequacy of the activation mechanism of thermal molecular motion in low-molecular liquids. The immanent contradiction of exponential temperature dependences for the viscosity and self-diffusion coefficients is proved. In all cases, the preference is given to qualitative arguments.
Rotation of a Thin Heated Plate by Its Own Thermal Radiation
Authors: Pipa V. I. , Liptuga A. I.
Published: December 2018

The results of the theoretical investigation of a heated solid plate rotation caused by its own thermal radiation are presented. The rotational moment of the plate with uniform temperature is due to the asymmetry of a recoil of photons of thermal radiation from different areas of its wide faces. The time dependences of the rotation angle of a rectangular plate with stable temperature and at radiative cooling are calculated. The rotation angle dependences on the plate geometric and optical parameters are studied. It is shown that the rotation angle depends nontrivially on the plate thickness because of the thickness-dependent plate emittance. The numerical calculations are performed for a silicon plate. The biggest rotation effect (rotation angle of 118.5∘ for 70 s) is obtained for a mirror black plate 0.1 mm thick at a preset plate temperature of 350 K and a background temperature of 300 K. The considered model can be useful to develop thermal motors, whose rotors consist of a set of heated plates with photon recoil asymmetry.