bluuebunny/crossref_metadata_2025 huggingface dataset:
Calcineurin B-Like Proteins CBL4 and CBL10 Mediate Two Independent Salt Tolerance Pathways in Arabidopsis
Authors: Yang Yang , Zhang Chi , Tang Ren-Jie , Xu Hai-Xia , Lan Wen-Zhi , Zhao Fugeng , Luan Sheng
Published: May 2019

In Arabidopsis, the salt overly sensitive (SOS) pathway, consisting of calcineurin B-like protein 4 (CBL4/SOS3), CBL-interacting protein kinase 24 (CIPK24/SOS2) and SOS1, has been well defined as a crucial mechanism to control cellular ion homoeostasis by extruding Na+ to the extracellular space, thus conferring salt tolerance in plants. CBL10 also plays a critical role in salt tolerance possibly by the activation of Na+ compartmentation into the vacuole. However, the functional relationship of the SOS and CBL10-regulated processes remains unclear. Here, we analyzed the genetic interaction between CBL4 and CBL10 and found that the cbl4 cbl10 double mutant was dramatically more sensitive to salt as compared to the cbl4 and cbl10 single mutants, suggesting that CBL4 and CBL10 each directs a different salt-tolerance pathway. Furthermore, the cbl4 cbl10 and cipk24 cbl10 double mutants were more sensitive than the cipk24 single mutant, suggesting that CBL10 directs a process involving CIPK24 and other partners different from the SOS pathway. Although the cbl4 cbl10, cipk24 cbl10, and sos1 cbl10 double mutants showed comparable salt-sensitive phenotype to sos1 at the whole plant level, they all accumulated much lower Na+ as compared to sos1 under high salt conditions, suggesting that CBL10 regulates additional unknown transport processes that play distinct roles from the SOS1 in Na+ homeostasis.
The Adaptive Mechanism of Plants to Iron Deficiency via Iron Uptake, Transport, and Homeostasis
Authors: Zhang Xinxin , Zhang Di , Sun Wei , Wang Tianzuo
Published: May 2019

Iron is an essential element for plant growth and development. While abundant in soil, the available Fe in soil is limited. In this regard, plants have evolved a series of mechanisms for efficient iron uptake, allowing plants to better adapt to iron deficient conditions. These mechanisms include iron acquisition from soil, iron transport from roots to shoots, and iron storage in cells. The mobilization of Fe in plants often occurs via chelating with phytosiderophores, citrate, nicotianamine, mugineic acid, or in the form of free iron ions. Recent work further elucidates that these genes’ response to iron deficiency are tightly controlled at transcriptional and posttranscriptional levels to maintain iron homeostasis. Moreover, increasing evidences shed light on certain factors that are identified to be interconnected and integrated to adjust iron deficiency. In this review, we highlight the molecular and physiological bases of iron acquisition from soil to plants and transport mechanisms for tolerating iron deficiency in dicotyledonous plants and rice.
Magnetoferritin: Process, Prospects, and Their Biomedical Applications
Authors: Xue Le , Deng Dawei , Sun Jianfei
Published: May 2019

Ferritin is a spherical iron storage protein composed of 24 subunits and an iron core. Using biomimetic mineralization, magnetic iron oxide can be synthesized in the cavity of ferritin to form magnetoferritin (MFt). MFt, also known as a superparamagnetic protein, is a novel magnetic nanomaterial with good biocompatibility and flexibility for biomedical applications. Recently, it has been demonstrated that MFt had tumor targetability and a peroxidase-like catalytic activity. Thus, MFt, with its many unique properties, provides a powerful platform for tumor diagnosis and therapy. In this review, we discuss the biomimetic synthesis and biomedical applications of MFt.
The L-Type Amino Acid Transporter LAT1—An Emerging Target in Cancer
Authors: Häfliger Pascal , Charles Roch-Philippe
Published: May 2019

Chronic proliferation is a major hallmark of tumor cells. Rapidly proliferating cancer cells are highly dependent on nutrients in order to duplicate their cell mass during each cell division. In particular, essential amino acids are indispensable for proliferating cancer cells. Their uptake across the cell membrane is tightly controlled by membrane transporters. Among those, the L-type amino acid transporter LAT1 (SLC7A5) has been repeatedly found overexpressed in a vast variety of cancers. In this review, we summarize the most recent advances in our understanding of the role of LAT1 in cancer and highlight preclinical studies and drug developments underlying the potential of LAT1 as therapeutic target.
DETELPROG Study. Effectiveness of a New Model of Scheduled Telephone Referral from Primary Care to Internal Medicine. A Randomised Controlled Study
Authors: Azogil-López Luis , Pérez-Lázaro Juan , Medrano-Sánchez Esther , Gómez-Salgado Juan , Coronado-Vázquez Valle
Published: May 2019

In Spain, the average waiting time for a specialist consultation is 58 days. A determinant factor that contributes to this situation is the poor communication between primary care and specialised care, which is mainly due to the waiting days for a consultation, number of avoided/avoidable face-to-face referrals, and waiting days for the resolution of the process. DETELPROG is a referral system in which the family physician requests a scheduled outpatient internal medicine consultation, integrated into the usual consultations agenda of both physicians, the family, and the outpatient clinic physician, in order to have a telephone consultation. A randomized controlled clinical trial has been carried out to assess the effectiveness of DELTELPROG. In a sample of 255 patients, the experimental group was referred via a scheduled telephone call, and those in the control group, by face-to-face hospital consultation area. The results showed statistically significant differences between both groups of 27 days (95% confidence interval (CI): 20–33) regarding specialised consultation, 47 days (95% CI: 17–74) as for the resolution of the process, and 91.7% for avoided face-to-face consultations. The DETELPROG resulted as a low coverage system (53%), which makes it a complementary referral model. It is necessary to make an in-depth analysis of the causes that have led to this technologically low coverage.
Pleural Tap-Guided Antimicrobial Treatment for Pneumonia with Parapneumonic Effusion or Pleural Empyema in Children: A Single-Center Cohort Study
Authors: Meyer Sauteur Patrick M. , Burkhard Ariane , Moehrlen Ueli , Relly Christa , Kellenberger Christian , Ruoss Kerstin , Berger Christoph
Published: May 2019

Parapneumonic effusion or pleural empyema (PPE/PE) is a frequent complication of community-acquired pneumonia (CAP) in children. Different management approaches exist for this condition. We evaluated a 14-day treatment with amoxicillin (AMX) with/without clavulanic acid (AMC) confirmed or modified by microbiological findings from pleural tap. Children ≤16 years of age with radiologically diagnosed PPE/PE and initial diagnostic pleural tap were included at University Children’s Hospital Zurich from 2001–2015. AMX/AMC was given for 14 days and rationalized according to microbiological pleural tap results. Clinical and radiological follow-up was scheduled until six months or full recovery. In 114 of 147 (78%) children with PPE/PE a pathogen was identified by culture, polymerase chain reaction (PCR), and/or antigen testing. Streptococcus pneumoniae was detected in 90 (79%), S. pyogenes in 13 (11%), and Staphylococcus aureus in seven cases (6%), all but two cultured pathogens (96%) were sensitive to AMX/AMC. One-hundred two of 147 (69%) patients received treatment with AMX/AMC for 14 days. They recovered more rapidly than patients with a different management (p = 0.026). Of 139 children with follow-up, 134 (96%) patients fully recovered. In conclusion, 14-day AMX/AMC treatment confirmed and rarely modified by microbiological findings from pleural tap resulted in full recovery in >95% of children with PPE/PE.
Stability and Bifurcation Analysis on a Predator–Prey System with the Weak Allee Effect
Authors: Zhang Jianming , Zhang Lijun , Bai Yuzhen
Published: May 2019

In this paper, the dynamics of a predator-prey system with the weak Allee effect is considered. The sufficient conditions for the existence of Hopf bifurcation and stability switches induced by delay are investigated. By using the theory of normal form and center manifold, an explicit expression, which can be applied to determine the direction of the Hopf bifurcations and the stability of the bifurcating periodic solutions, are obtained. Numerical simulations are performed to illustrate the theoretical analysis results.
Research on Grain Refinement in Hypoeutectic Al-Si Alloy during Solidification under an Alternating Electric Current Pulse
Authors: Li Ning , Zhang Limin , Zhang Rong , Yin Pengfei , Xing Hui , Wu Hongjing
Published: May 2019

Experiments on transient directional solidification were carried out to study the columnar to equiaxed transition (CET) in Al-7Si alloy without and with an alternating electric current pulse (AECP). Without AECP, the macrostructure consists of typical columnar and equiaxed zones, separated by a near horizontal plane. As the AECP is applied during solidification, an additional fine equiaxed zone (FEZ) occurs in the as-cast macrostructure. From measured temperature profiles, cooling rate and temperature gradient are determined. It is found that CET occurs for a critical value of the cooling rate, which is observed to be about 0.14 K·s−1 in the present investigation. Furthermore, the macrostructural observation with mold for embedding the mesh plate demonstrates that the major factor responsible for the formation of fine equiaxed grains is the detachment of crystal nuclei from the upper contact surface and the lateral wall. The detachment is in turn ascribed to electric current-associated free energy change (ΔGe)-induced the driving force F.
Shiga-Toxin Producing Escherichia Coli in Brazil: A Systematic Review
Authors: Castro Vinicius Silva , Figueiredo Eduardo Eustáquio de Souza , Stanford Kim , McAllister Tim , Conte-Junior Carlos Adam
Published: May 2019

Shiga-toxin producing E. coli (STEC) can cause serious illnesses, including hemorrhagic colitis and hemolytic uremic syndrome. This is the first systematic review of STEC in Brazil, and will report the main serogroups detected in animals, food products and foodborne diseases. Data were obtained from online databases accessed in January 2019. Papers were selected from each database using the Mesh term entries. Although no human disease outbreaks in Brazil related to STEC has been reported, the presence of several serogroups such as O157 and O111 has been verified in animals, food, and humans. Moreover, other serogroups monitored by international federal agencies and involved in outbreak cases worldwide were detected, and other unusual strains were involved in some isolated individual cases of foodborne disease, such as serotype O118:H16 and serogroup O165. The epidemiological data presented herein indicates the presence of several pathogenic serogroups, including O157:H7, O26, O103, and O111, which have been linked to disease outbreaks worldwide. As available data are concentrated in the Sao Paulo state and almost completely lacking in outlying regions, epidemiological monitoring in Brazil for STEC needs to be expanded and food safety standards for this pathogen should be aligned to that of the food safety standards of international bodies.
Chlamydia trachomatis and Chlamydia pneumoniae Interaction with the Host: Latest Advances and Future Prospective
Authors: Di Pietro Marisa , Filardo Simone , Romano Silvio , Sessa Rosa
Published: May 2019

Research in Chlamydia trachomatis and Chlamydia pneumoniae has gained new traction due to recent advances in molecular biology, namely the widespread use of the metagenomic analysis and the development of a stable genomic transformation system, resulting in a better understanding of Chlamydia pathogenesis. C. trachomatis, the leading cause of bacterial sexually transmitted diseases, is responsible of cervicitis and urethritis, and C. pneumoniae, a widespread respiratory pathogen, has long been associated with several chronic inflammatory diseases with great impact on public health. The present review summarizes the current evidence regarding the complex interplay between C. trachomatis and host defense factors in the genital micro-environment as well as the key findings in chronic inflammatory diseases associated to C. pneumoniae.
A Review: The Bioactivities and Pharmacological Applications of Phellinus linteus
Authors: Chen Wenhua , Tan Huiying , Liu Qian , Zheng Xiaohua , Zhang Hua , Liu Yuhong , Xu Lingchuan
Published: May 2019

Phellinus linteus is a popular medicinal mushroom that is widely used in China, Korea, Japan, and other Asian countries. P. linteus comprises various bioactive components, such as polysaccharides, triterpenoids, phenylpropanoids, and furans, and has proven to be an effective therapeutic agent in traditional Chinese medicine for the treatment and the prevention of various diseases. A number of studies have reported that P. linteus possesses many biological activities useful for pharmacological applications, including anticancer, anti-inflammatory, immunomodulatory, antioxidative, and antifungal activities, as well as antidiabetic, hepatoprotective, and neuroprotective effects. This review article briefly presents the recent progress made in understanding the bioactive components, biological activities, pharmacological applications, safety, and prospects of P. linteus, and provides helpful references and promising directions for further studies of P. linteus.
Rapid Detection of Adulterants in Whey Protein Supplement by Raman Spectroscopy Combined with Multivariate Analysis
Authors: Jiao Xianzhi , Meng Yaoyong , Wang Kangkang , Huang Wei , Li Nan , Liu Timon Cheng-Yi
Published: May 2019

The growing demand for whey protein supplements has made them the target of adulteration with cheap substances. Therefore, Raman spectroscopy in tandem with chemometrics was proposed to simultaneously detect and quantify three common adulterants (creatine, l-glutamine and taurine) in whey protein concentrate (WPC) powder. Soft independent modeling class analogy (SIMCA) and partial least squares discriminant analysis (PLS-DA) models were built based on two spectral regions (400–1800 cm−1 and 500–1100 cm−1) to classify different types of adulterated samples. The most effective was the SIMCA model in 500–1100 cm−1 with an accuracy of 96.9% and an error rate of 5%. Partial least squares regression (PLSR) models for each adulterant were developed using two different Raman spectral ranges (400–1800 cm−1 and selected specific region) and data pretreatment methods. The determination coefficients (R2) of all models were higher than 0.96. PLSR models based on typical Raman regions (500–1100 cm−1 for creatine and taurine, the combination of range 800–1000 cm−1 and 1300–1500 cm−1 for glutamine) were superior to models in the full spectrum. The lowest root mean squared error of prediction (RMSEP) was 0.21%, 0.33%, 0.42% for creatine, taurine and glutamine, and the corresponding limit of detection (LOD) values for them were 0.53%, 0.71% and 1.13%, respectively. This proves that Raman spectroscopy with the help of multivariate approaches is a powerful method to detect adulterants in WPC.
The Role of Electron Transfer in the Nonlinear Response of Ge2Sb2Te5-Mediated Plasmonic Dimers
Authors: Gerislioglu Burak , Ahmadivand Arash
Published: May 2019

Here, we study the possibility of exquisitely selective harmonic generation based on the concept of charge transfer plasmons (CTPs) in bridged nanoparticle assemblies. By choosing plasmonic dimer nanoantenna, as a fundamental member of the nanocluster family, and bridging the capacitive gap space between the proximal nanoparticles with an optothermally controllable substance, we judiciously showed that variations in the generation of third harmonic light in the visible regime can be possible by considering distinct states of the functional bridge. To this end, the conductive connection between the nanoparticles is mediated with Ge2Sb2Te5 (GST) with inherently opposite optical and electrical properties below (dielectric, amorphous state) and above 477 °C (conductive, crystalline state). This helped to actively control the transition of charges across the bridge and thereby control the excitation of CTP resonances and provide a switching feature between dipolar and CTP modes. This versatile approach also allowed for production of the intended harmonic signal at different wavelengths depending on the conductivity of the interparticle nanojunction.
Lipophilic Metabolites and Anatomical Acclimatization of Cleome amblyocarpa in the Drought and Extra-Water Areas of the Arid Desert of UAE
Authors: Soliman Sameh S.M. , Abouleish Mohamed , Abou-Hashem Maged M.M. , Hamoda Alshaimaa M. , El-Keblawy Ali A.
Published: May 2019

Plants adapt to different environmental conditions by developing structural and metabolic mechanisms. In this study, anatomical features and lipophilic metabolites were investigated in Cleome amblyocarpa Barr. & Murb., Cleomaceae plants growing in the arid desert of United Arab Emirates (UAE) in either low-water or extra-water areas, which were caused by the surrounding road run-off. The plant showed the presence of shaggy-like trichomes. The plant also developed special mechanisms to ensure its survival via release of lipophilic metabolites. The lipophilic metabolites, stained red with Sudan III, were apparently released by glandular trichomes and idioblasts of the shoot and roots, respectively. The identified lipophilic metabolites included those required for drought tolerance, protection against pathogens invasion, and detoxification. Plants growing in the low-water area caused an increase in the production of lipophilic metabolites—in particular, hydrocarbons and terpenoids. The lipophilic metabolites are known to provide the plant with unique waxy surfaces that reduce water loss and avoid penetration by pathogens. The release of lipid metabolites and the presence of shaggy-like trichomes represented unique features of the species that have never been reported. The provided chemical ecology information can be extended for several plant-related applications, particularly including drought tolerance.
Application of Hyperspectral Imaging to Underwater Habitat Mapping, Southern Adriatic Sea
Authors: Foglini Federica , Grande Valentina , Marchese Fabio , Bracchi Valentina A. , Prampolini Mariacristina , Angeletti Lorenzo , Castellan Giorgio , Chimienti Giovanni , Hansen Ingrid M. , Gudmundsen Magne , Meroni Agostino N. , Mercorella Alessandra , Vertino Agostina , Badalamenti Fabio , Corselli Cesare , Erdal Ivar , Martorelli Eleonora , Savini Alessandra , Taviani Marco
Published: May 2019

Hyperspectral imagers enable the collection of high-resolution spectral images exploitable for the supervised classification of habitats and objects of interest (OOI). Although this is a well-established technology for the study of subaerial environments, Ecotone AS has developed an underwater hyperspectral imager (UHI) system to explore the properties of the seafloor. The aim of the project is to evaluate the potential of this instrument for mapping and monitoring benthic habitats in shallow and deep-water environments. For the first time, we tested this system at two sites in the Southern Adriatic Sea (Mediterranean Sea): the cold-water coral (CWC) habitat in the Bari Canyon and the Coralligenous habitat off Brindisi. We created a spectral library for each site, considering the different substrates and the main OOI reaching, where possible, the lower taxonomic rank. We applied the spectral angle mapper (SAM) supervised classification to map the areal extent of the Coralligenous and to recognize the major CWC habitat-formers. Despite some technical problems, the first results demonstrate the suitability of the UHI camera for habitat mapping and seabed monitoring, through the achievement of quantifiable and repeatable classifications.
Non-Uniform Concentric Rings Design for Ultra-Wideband Arrays
Authors: Panduro Marco A. , Reyna Alberto , Covarrubias David H.
Published: May 2019

This paper presents the design of aperiodic concentric ring arrays for ultra-wide bandwidths (UW-ACRA). This design of ultra-wideband arrays considers the synthesis of concentric rings in two cases: 1) non-uniform spacing between rings with non-uniform spacing between antenna elements of the same ring (UW-ACRAelements); and 2) non-uniform spacing between rings assuming that spacing between antenna elements of the same ring to be equal (UW-ACRArings). This is in order to eliminate the occurrence of grating lobes and generating array structures with useful ultra-wideband properties. The synthesis process is carried out by the well-known method of differential evolution (DE). Wireless sensor networks can take advantage of these properties to achieve less data traffic, efficient delivery of information and better energy efficiency.
Self-Embedding Authentication Watermarking with Effective Tampered Location Detection and High-Quality Image Recovery
Authors: Lee Chin-Feng , Shen Jau-Ji , Chen Zhao-Ru , Agrawal Somya
Published: May 2019

Recently, sensor networks have emerged as a high-impact research area, and a number of high profile applications have been proposed. Although significant progress has already been made on securing basic network protocols, additional research is needed to produce techniques and methods for protecting canonical tasks in wireless sensor networks. In this paper, we propose an effective self-embedding authentication watermarking method for tampered location detection and image recovery. The proposed detection method is classified into block-wise and pixel-wise. In block-wise detection, if the size of the block is small, the false positive rate (FPR) will be low. In pixel-wise detection, when the tampered pixels are detected, only the corresponding pixel area is marked. Therefore, the FPR will be lower than that of the block-wise detection. The experimental results demonstrate that the proposed method was effective, and accurate tamper detection and high-quality recovery can be realized even in highly tampered images.
On Optimal Imaging Angles in Multi-Angle Ocean Sun Glitter Remote-Sensing Platforms to Observe Sea Surface Roughness
Authors: Wang Dazhuang , Zhao Liaoying , Zhang Huaguo , Wang Juan , Lou Xiulin , Chen Peng , Fan Kaiguo , Shi Aiqin , Li Dongling
Published: May 2019

Sea surface roughness (SSR) is a key physical parameter in studies of air–sea interactions and the ocean dynamics process. The SSR quantitative inversion model based on multi-angle sun glitter (SG) images has been proposed recently, which will significantly promote SSR observations through multi-angle remote-sensing platforms. However, due to the sensitivity of the sensor view angle (SVA) to SG, it is necessary to determine the optimal imaging angle and their combinations. In this study, considering the design optimization of imaging geometry for multi-angle remote-sensing platforms, we have developed an error transfer simulation model based on the multi-angle SG remote-sensing radiation transmission and SSR estimation models. We simulate SSR estimation errors at different imaging geometry combinations to evaluate the optimal observation geometry combination. The results show that increased SSR inversion accuracy can be obtained with SVA combinations of 0° and 20° for nadir- and backward-looking SVA compared with current combinations of 0° and 27.6°. We found that SSR inversion prediction error using the proposed model and actual SSR inversion error from field buoy data are correlated. These results can provide support for the design optimization of imaging geometry for multi-angle ocean remote-sensing platforms.
Experimental Study of Leakage Monitoring of Diaphragm Walls Based on Distributed Optical Fiber Temperature Measurement Technology
Authors: Liu Tao , Sun Wenjing , Kou Hailei , Yang Zhongnian , Meng Qingsheng , Zheng Yuqian , Wang Haotong , Yang Xiaotong
Published: May 2019

In geotechnical engineering seepage of diaphragm walls is an important issue which may cause engineering disasters. It is therefore of great significance to develop reliable monitoring technology to monitor the leakage. The purpose of this study is to explore the application of a distributed optical fiber temperature measurement system in leakage monitoring of underground diaphragm walls using 1 g model tests. The principles of seepage monitoring based on distributed optical fiber temperature measurement technology are introduced. Fiber with heating cable was laid along the wall to control seepage flow at different speeds. The temperature rise of the fiber during seepage was also recorded under different heating power conditions. In particular the effect of single variables (seepage velocity and heating power) on the temperature rise of optical fibers was discussed. Test results indicated that the temperature difference between the seepage and non-seepage parts of diaphragm wall can be monitored well using fiber-optic external heating cable. Higher heating power also can improve the resolution of fiber-optic seepage. The seepage velocity had a linear relationship with the final stable temperature after heating, and the linear correlation coefficient increases with the increase of heating power. The stable temperature decreased with the increase of flow velocity. The findings provide a basis for quantitative measurement and precise location of seepage velocity of diaphragm walls.
A Resonant Pressure Microsensor with the Measurement Range of 1 MPa Based on Sensitivities Balanced Dual Resonators
Authors: Lu Yulan , Yan Pengcheng , Xiang Chao , Chen Deyong , Wang Junbo , Xie Bo , Chen Jian
Published: May 2019

This paper presents a resonant pressure microsensor with the measurement range of 1 MPa suitable for the soaring demands of industrial gas pressure calibration equipment. The proposed microsensor consists of an SOI layer as a sensing element and a glass cap for vacuum packaging. The sensing elements include a pressure-sensitive diaphragm and two resonators embedded in the diaphragm by anchor structures. The resonators are excited by a convenient Lorentz force and detected by electromagnetic induction, which can maintain high signal outputs. In operation, the pressure under measurement bends the pressure-sensitive diaphragm of the microsensor, producing frequency shifts of the two underlining resonators. The microsensor structures were designed and optimized using finite element analyses and a 4” SOI wafer was employed in fabrications, which requires only one photolithographic step. Experimental results indicate that the Q-factors of the resonators are higher than 25,000 with a differential temperature sensitivity of 0.22 Hz/°C, pressure sensitivities of 6.6 Hz/kPa, and −6.5 Hz/kPa, which match the simulation results of differential temperature sensitivity of 0.2 Hz/°C and pressure sensitivities of ±6.5 Hz/kPa. In addition, characterizations based on a closed-loop manner indicate that the presented sensor demonstrates low fitting errors within 0.01% FS, high accuracy of 0.01% FS in the pressure range of 20 kPa to 1 MPa and temperature range of −55 to 85 °C, and the long-term stability within 0.01% FS in a 156-day period under the room temperature.
A Novel Rule-Based Approach in Mapping Landslide Susceptibility
Authors: Roodposhti Majid , Aryal Jagannath , Pradhan Biswajeet
Published: May 2019

Despite recent advances in developing landslide susceptibility mapping (LSM) techniques, resultant maps are often not transparent, and susceptibility rules are barely made explicit. This weakens the proper understanding of conditioning criteria involved in shaping landslide events at the local scale. Further, a high level of subjectivity in re-classifying susceptibility scores into various classes often downgrades the quality of those maps. Here, we apply a novel rule-based system as an alternative approach for LSM. Therein, the initially assembled rules relate landslide-conditioning factors within individual rule-sets. This is implemented without the complication of applying logical or relational operators. To achieve this, first, Shannon entropy was employed to assess the priority order of landslide-conditioning factors and the uncertainty of each rule within the corresponding rule-sets. Next, the rule-level uncertainties were mapped and used to asses the reliability of the susceptibility map at the local scale (i.e., at pixel-level). A set of If-Then rules were applied to convert susceptibility values to susceptibility classes, where less level of subjectivity is guaranteed. In a case study of Northwest Tasmania in Australia, the performance of the proposed method was assessed by receiver operating characteristics’ area under the curve (AUC). Our method demonstrated promising performance with AUC of 0.934. This was a result of a transparent rule-based approach, where priorities and state/value of landslide-conditioning factors for each pixel were identified. In addition, the uncertainty of susceptibility rules can be readily accessed, interpreted, and replicated. The achieved results demonstrate that the proposed rule-based method is beneficial to derive insights into LSM processes.
Application of Electric Cell-Substrate Impedance Sensing to Investigate the Cytotoxic Effects of Andrographolide on U-87 MG Glioblastoma Cell Migration and Apoptosis
Authors: Chiu Sheng-Po , Batsaikhan Buyandelger , Huang Huei-Mei , Wang Jia-Yi
Published: May 2019

Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults. In recent studies, the efficacy of suberoylanilide hydroxamic acid (SAHA) has been investigated for GBM. We explored the effects of two exploratory compounds, the histone deacetylase SAHA and the natural product andrographolide, on Uppsala 87 Malignant Glioma (U-87 MG) cell migration and viability in comparison with the clinically used therapeutic agent temozolomide (TMZ). We used the electric cell–substrate impedance sensing (ECIS) system to monitor the migration of U-87 MG cells after treatment with various concentrations of these compounds. Moreover, we used the Alamar blue assay and western blotting to observe the concentration-dependent changes in the viability and apoptosis of U-87 MG cells. Our results demonstrated that both SAHA and andrographolide (10–300 μM) significantly inhibited GBM cell migration in a concentration-dependent manner, and 10 μM SAHA and 56 μM andrographolide demonstrated remarkable inhibitory effects on U-87 MG migration. Western blotting indicated that compared with TMZ, both SAHA and andrographolide induced higher expression levels of apoptosis-related proteins, such as caspase-3, BAX, and PARP in U-87 MG cells. Furthermore, all three drugs downregulated the expression of the antiapoptotic protein Bcl-2. In conclusion, SAHA and andrographolide showed exceptional results in inhibiting cell migration and motility. The ECIS wound healing assay is a powerful technique to identify and screen potential therapeutic agents that can inhibit cancer cell migration.
Validity and Reliability of an Electronic Contact Mat for Drop Jump Assessment in Physically Active Adults
Authors: Tenelsen Florian , Brueckner Dennis , Muehlbauer Thomas , Hagen Marco
Published: May 2019

The aim of the present study was to investigate the concurrent validity and the test–retest reliability of an electronic contact mat for drop jump assessment in physically active adults. Seventy-nine young, physically active adults participated in the validity study, and 49 subjects were recruited for the reliability study. The motor task required subjects to perform two-legged drop jumps using drop heights of 24, 43, and 62 cm as well as one-legged drop jumps with the left and right leg using a drop height of 24 cm. Ground contact times were simultaneously quantified with an electronic contact mat, a force plate (i.e., gold standard), and a light-barrier system (another criterion device). Concurrent validity was assessed using intraclass correlation coefficient (ICC), systematic bias, limits of agreement, and linear regression analysis. Test–retest reliability (one week apart) was determined by calculating the ICC, the standard error of measurement (SEM), the coefficient of variation (CV), and Lin´s concordance correlation coefficient (рc). Further, we determined the minimal detectable change (MDC95%). Irrespective of drop height and jump condition, good agreements between testing devices (ICC ≥ 0.95) were shown. Compared to the force plate (−0.6 to 3.1 ms) but not to the light-barrier system (31.4 to 41.7 ms), the contact mat showed low systematic bias values. In terms of test–retest reliability, our analyses showed that the measuring devices are in agreement (ICC: 0.70–0.92; SEM: 8.5–18.4 ms; CV: 3.6–6.4%). Depending on the measurement device, drop height, and jump condition, a MDC95% value ranging from 23.6 to 50.9 ms represents the minimum amount of change needed to identify practical relevant effects in repeated measurements of drop jump performance. Our findings indicate that the electronic contact mat is a valid and reliable testing device for drop jump assessment from different drop heights in young physically active adults.
Effects of Cycling on Subsequent Running Performance, Stride Length, and Muscle Oxygen Saturation in Triathletes
Authors: Olcina Guillermo , Perez-Sousa Miguel , Escobar-Alvarez Juan , Timón Rafael
Published: May 2019

Running performance is a determinant factor for victory in Sprint and Olympic distance triathlon. Previous cycling may impair running performance in triathlons, so brick training becomes an important part of training. Wearable technology that is used by triathletes can offer several metrics for optimising training in real-time. The aim of this study was to analyse the effect of previous cycling on subsequent running performance in a field test, while using kinematics metrics and SmO2 provided by wearable devices that are potentially used by triathletes. Ten trained triathletes participated in a randomised crossover study, performing two trial sessions that were separated by seven days: the isolated run trial (IRT) and the bike-run trial (BRT). Running kinematics, physiological outcomes, and perceptual parameters were assessed before and after each running test. The running distance was significantly lower in the BRT when compared to the IRT, with a decrease in stride length of 0.1 m (p = 0.00) and higher %SmO2 (p = 0.00) in spite of the maximal intensity of exercise. No effects were reported in vertical oscillation, ground contact time, running cadence, and average heart rate. These findings may only be relevant to ‘moderate level’ triathletes, but not to ‘elite’ ones. Triathletes might monitor their %SmO2 and stride length during brick training and then compare it with isolated running to evaluate performance changes. Using wearable technology (near-infrared spectroscopy, accelerometry) for specific brick training may be a good option for triathletes.
Tradisi Massuru’ dan Pertobatan Dalam Injil Sinoptik
Authors: Rumbi Frans Paillin
Published: May 2019

This paper juxtaposes two models of wrong forgiveness and sin. Massuru 'in Toraja culture and repentance in the gospel. This research study is explanatory in order to explain the concept of masu suru and repentance from the theological roots that shape it. The materials used are sourced from the literature but in dialogue with the observations or experiences that the author has encountered in the field, both when observing the way the Toraja interpret their traditions and interpret liturgical confessions in the congregation. The results of this study found that massuru and repentance had a more or less the same basic pattern, which was initiated by false recognition or sin, forgiveness and finally peace. Another similarity is improving behavior, reestablishing relations with God and fellow creatures. But there are differences in terms of initiative, targets in the visible and inner aspects, atonement victims. Massuru 'can be used as a model for confession in congregations and repentant pastoral models, but it needs to adjust its meaning to the values of the contain of Christian teachings. AbstrakTulisan ini menyandingkan dua model pengampunan salah dan dosa. Massuru’ dalam kebudayan Toraja dan pertobatan dalam Injil. Kajian penelitian ini bersifat eksplanasi untuk menjelaskan konsep massuru’ dan pertobatan dari akar tradisi-teologis yang membentuknya. Bahan-bahan yang digunakan bersumber dari kepustakaan tetapi di dialogkan dengan pengamatan atau pengalaman yang selama ini penulis jumpai di lapangan, baik ketika mengamati cara orang Toraja memaknai tradisinya maupun memaknai liturgi pengakuan dosa dalam jemaat. Hasil penelitian ini menemukan bahwa massuru’ dan pertobatan memiliki pola dasar yang kurang lebih sama, yakni dimulai dengan pengakuan salah atau dosa, pengampunan dan akhirnya perdamaian. Kesamaan lain yakni memperbaiki perilaku, membangun kembali relasi dengan Allah dan sesama ciptaan.  Tetapi terdapat perbedaan dari segi inisiatif, sasaran pada aspek kelihatan dan batin, korban pendamaian. Massuru’ dapat digunakan sebagai model akta pengakuan dosa dalam jemaat maupun model pastoral tobat, akan tetapi perlu menyesuaikan maknanya dengan nilai-nilai yang terkandung alam ajaran Kristen.
Kualitas Pemimpin Sebagai Pendidik Dalam Menghadapi Konflik
Authors: Tanyid Maidiantius
Published: May 2019

The leader is the person whom is responsible to ensure all the task will be done. Therefore the leader needs to delegate those tasks for each person that was considered has some competences. A leaders as an educator must be able to carry out leadership base on the truth of God which always educate and motivate the team work. Being a leader who able to educate or as educator who can lead is two resposibilities those cannot be separated. Because the leader as an educator must be able to demonstrate their integrity based on truth. AbstrakPemimpin merupakan orang yang bertanggung jawab melakukan tugas, dan tugas itu dipercayakan kepada setiap bawahan yang dianggap dapat bertanggungjawab melakukannya sesuai dengan kompetensi.  Pemimpin sebagai pendidik adalah pemimpin yang mampu menjalankan kepemimpinan dengan berstandar kebenaran, mendidik dan memotivasi.  Menjadi pemimpin yang mampu mendidik dan pendidik yang dapat memimpin, dan dua kata penting yaitu “pemimpin dan pendidik” tidak dapat dipisahkan dalam menjalankan tanggungjawab. Pemimpin yang mampu menjalankan tanggung jawab sebagai pemimpin sekaligus menjadi pendidik adalah pemimpin yang mampu menunjukkan integritasnya berdasarkan kebenaran.
Refleksi Teologis Kitab Yeremia tentang Pesan Sang Nabi Bagi Orang-orang Buangan
Authors: Sitorus Herowati
Published: May 2019

The Book of Jeremiah is very difficult to understand because the events are not in chronological order. Jeremiah understanding by critical studies provides a more complete understanding even though it was written not in chronological order. This study is built on the understanding of the supervisor writing the book that would expose us, the author of the book, the time and place of writing, the outline of the contents of the book. Historical background, social and political book is also very necessary to study to provide a broader picture of the book of Jeremiah. Jeremiah did his job during the reforms of Josiah in 621 BC, (2) reign of Jehoiakim king in 609 BC, (3) the reign of King Jehoiachin in December 598 to March 597 BC, and (4) of Zedekiah in 597-587 BC.Abstrak: Kitab Yeremia merupakan kitab yang sangat sulit dipahami karena peristiwa-peristiwa yang terjadi di dalamnya tidak berlangsung secara teratur. Memahami Yeremia dengan kajian-kajian yang kritis memberikan sebuah pemahaman yang lebih lengkap sekalipun tidak ditulis secara urut. Kajian ini dibangun atas pemahaman tentang penulisan kitab yang akan menyingkapkan tentang penulis kitab, waktu dan tempat penulisan, garis besar kitab. Latar belakang sejarah, baik secara politik dan ekonomi juga sangat penting untuk dikaji untuk memberikan gambaran yang lebih luas tentang kitab Yeremia. Yeremia melakukan pekerjaannya selama reformasi Yosia pada tahun 621 SM; pemerintahan raja Yoyakhim pada tahun 609; pemerintahan raja Yehoakim pada Desember 598 hingga Maret 597 SM, serta pada masa raja Zedekia tahun 597-587 SM.
Pengaruh Kualitas Layanan terhadap Loyalitas Konsumen melalui Variabel Intervening Kepuasan Konsumen pada Warung Kelontong di Kecamatan Banjarmasin Timur
Authors: Jaya Fanlia Prima , Suryasari R Gusti
Published: May 2019

type of research is explanatory research that aims to explain the causal relationship between variables through hypothesis testing and is also a conclusive research. The population of this study was overall Consumers who use the Convenience Store in Kecamatan BanjarmasinTimur, that as many as 118.429 people. The results of this study indicate that the results of validity and reliability of all the variables are significantly related and reliable. Classic assumption test consisting of Multicollinearity test, test heterocedastity, Autokolerasi test, normality test showed no irregularities. After linear regression analysis consisting of t-test and Anova it can be concluded that the Service Quality and Consumers Satisfaction as intervening simultaneously significant effect on Consumers Loyalty at Convenience Store in Kecamatan BanjarmasinTimur, The size of the effect can be seen from the coefficient terminated or R2 = 0.297.Keywords :Service Quality,Consumers Satisfaction, Consumers Loyalty.
Analisis Faktor-Faktor yang Berpengaruh terhadap Tingkat Keberhasilan pada Perusahaan-Perusahaan Dagang di Kotamadya Banjarmasin
Authors: Rudiansyah Muhammad
Published: May 2019

This research is aimed to analize to factors that success of business. The factors analize in the research are; X1 (net selling), X2 (cost expense), X3 (working capital), X4 (gross profit), X5 (profit margin), X6 (total assets), dan X7 (turnover assets). The analysis tool that is used in the research is the multiple linier regression model, regression equations that show the variables X1 , X2 , X3 , X4 , X5 , X6 simultaneously give sinigficant afferst to variable Y. This is show in the test F result calculation (2,897) is higher than the table F (2,17), and its probability value (1.778E-9) is lower the value of alfa ( ? = 0,05) While the dominant factor that affects sucsess of business is the profit margin (X5).Key words; net selling, cost expense, working capita), gross profit, profit margin, total assets, turnover assets.
ANALISIS PENGARUH.PENGEMBANGAN KARIR DAN KOMPENSASI TERHADAP KEPUASAN KERJA KARYAWAN PT PELAT TIMAH NUSANTARA, Tbk
Authors: Silitonga SE MM Dr. P Eddy Sanusi
Published: May 2019

This research was entitled "Influence Analysis of Career Development and Compensation to Employees Work Satisfaction at PT. Pelat Timah Nusantara, Tbk. The purpose of this research was to obtain the information about relationship between independent variables which are career development eX) and compensation ~) with dependent variable is employee satisfaction (y), either partially or simultaneously. The method was used IS with Explanatory Analysis approach which describes the causality relationship between variables. The sampling technique can be done randomly (simple random sampling) of 220 respondents, but samples which can be used only 69 employees and to resolve the problems, by analyze and test the relationship and influence between independent variables to dependent variables was used causality models through-regression analysis. The results of this research were; 1). Simultaneously, career development and compensation have positive influence, strong and significant to employees work satisfaction at PT. Pelat Timab Nusantara Tbk. It was indicated by the acquisition of R-Square is 65% and remaining 35% is influenced by other factors which not examined were absent level of employees was high enough, work environment was less conducive and leaders whose less understand the level of employees capabilities. 2). Partially, career development have positive influence, strong enough and significant to employees work satisfaction at PT Pelat Timah Nusantara Tbk, It is indicated by the acquisition ofR-Square is 56%.3). Partially, compensation have positive influence, weak and significant to employees work satisfaction at PT Timab Nusantara Plates, Tbk. It is indicated by the acquisition ofR-square is 37%.
Membangun brand image positif melalui Green marketing? Pengaruh green marketing, brand image dan environmental knowledge terhadap keputusan pembelian
Authors: Paramitra, SE., MSM. Yuaniko
Published: May 2019

The purpose of this study is to analyze the effect of green marketing on green purchase behavior. The research was conducted in an explanatory, and using quantitative. The study sample was 66 of the participants in the environmental care activities. The sampling technique used in this study is purposive sampling. The results showed that the variables of green marketing, brand image and environmental knowledge simultaneously and partially had a positive effect on green purchase behavior. While brand image and environmental knowledge variables can increase the influence of green marketing on purchasing decisions.
PENGARUH EKSPOR, IMPOR DAN NILAI KURS TERHADAP INFLASI DAN DAMPAKNYA TERHADAP RETURN PASAR DI BURSA EFEK INDONESIA
Authors: Sodiqin Akhmad
Published: May 2019

The aim of this research is to analyze influence of macro variables which is expor, import and exchange to inflation partially or siumltanously and its impact to market return in capital market. Data which used to analyze that taken form 2011 untill 2013 of the year. Based on analyze, it concluded that export, import, exchange rate and inflation didn’t influence to inflation partially or simultanously which hapenned from 2011 untill 2013. Based path analyzes conncluded that export, import and exchange rate didn’t influence to market return through inflation.
ASPEK-ASPEK PENDEKATAN DAN METODE KUANTITATIF YANG MEMENGARUHI PERENCANAAN KREDIT
Authors: Luntungan Benjamin Lemta
Published: May 2019

Credit management is an act of managing credit by bank, consisting every stage of planning, organizing, actuating, and controlling, so that the credit itself can be absorbed by the market, while it is still in alignment with regulations. Hence it can be major source of income for the banks. Within planning stage, bank should consider all aspects that can affect plan formulation, such as fund structuring, laws and regulations on reserve requirement, legal lending limit, loan to deposit ratio, and other laws and regulations related to credit funding and banking activities. This paper will discuss several approaches on credit funding and also several quanitative methodes for determining credit volume and alocation. These quantitative methods will give us value of credit that will be marketed on certain period.
ANALISIS PENERAPAN METODE PROJECT MANAGEMENT PADA BAGIAN PERENCANAAN “ PT X “
Authors: Indra Harry
Published: May 2019

Along with the industrial competition nowaydays, an exact and strategic planning is highly required particulary for project. There are alot of tasks and activities within, which need to be broken down, in this term for its time line. Every success and failure is caused by raw palnning. The obyective of this research is to find efective time needed to complete a project. Method used are Critical Path Method (CPM) , Program Evaluation and Review Technique (PERT), andGantt Chart.