bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of Allergic Polymerized Impurities in Cephalosporins by
MALDI-TOF MS/MS Spectrometry
Authors: Wang Jian , Wang Dandan
Published: March 2022

Background:

Characterization of allergic polymerized impurities in cephalosporins is significant to ensure the safety and quality of the products.

Objective:

The aim of the study was to develop a MALDI-TOF MS/MS method to characterize the structures of polymerized impurities in cefuroxime axetil drug substance and cefetamet pivoxil drug substance.

Methods:

Calibrant references were TOF mix, including Angiotensin 2, Angiotensin 1, Glu-1-fibrino, N-Acetyl renin, ACTH 1-17, ACTH 18-39, and ACTH 7-38. Matrix was DHB at a con-centration of 10 mg·mL-1. Acetone and water were used as solvents to dissolve cefuroxime axetil and cefetamet pivoxil hydrochloride drug substances, respectively. The prepared solutions were mixed with DHB, volatilized to dry, and subjected to MALDI-TOF MS/MS analysis, respectively. MS data were obtained in the linear mode with a power of 80, and MS2 data were obtained in the reflection mode with a power of 120. Molecular weights of polymerized impurities in cefuroxime axetil and cefetamet pivoxil were obtained based on the MS data. Their fragmentation patterns and structural assignments were studied based on the MS2 data.

Results:

Eight polymerized impurities in cefuroxime axetil drug substance and cefetamet pivoxil hydrochloride drug substance made in China were characterized by matrix-assisted laser desorp-tion/ionization time-of-flight mass spectrometry (MALDI-TOF MS/MS), among which impurity Ⅰ-Ⅴ were in cefuroxime axetil and impurities Ⅵ-Ⅷ were in cefetamet pivoxil. Based on the ex-perimental results, the polymerization mechanism of polymerized impurities in cephalosporins was discussed.

Conclusion:

MALDI-TOF MS/MS proved to be simple, quick and sensitive for the analysis of polymerized impurities in cephalosporins.
Extracellular Vesicles in the Pathogenesis, Treatment, and Diagnosis of
Spinal Cord Injury: A Mini-Review
Authors: Wang Yang , Xu Hualiang , Wang Jian , Yi Hanxiao , Song Yancheng
Published: March 2022

Background:

Benefiting from in-depth research into stem cells, extracellular vesicles (EVs),
which are byproducts of cells and membrane-wrapped microvesicles (30-120 nm) containing lipids, proteins,
and nucleic acids, may cast light on the research and development of therapeutics capable of improving
the neurological recovery of spinal cord injury (SCI) animals. However, the mechanistic modes
of action for EVs in alleviating the lesion size of SCI remain to be solved, thus presenting a tremendous
gap existing in translation from the laboratory to the clinic.

Objective:

The purpose of this minireview was to cover a wide range of basic views on EVs involved in
SCI treatment, including the effects of EVs on the pathogenesis, treatment, and diagnosis of spinal cord
injury.

Methods:

We searched databases (i.e., PubMed, Web of Science, Scopus, Medline, and EMBASE) and
acquired all accessible articles published in the English language within five years. Studies reporting laboratory
applications of EVs in the treatment of SCI were included and screened to include studies presenting
relevant molecular mechanisms.

Results:

This review first summarized the basic role of EVs in cell communication, cell death, inflammatory
cascades, scar formation, neuronal regrowth, and angiogenesis after SCI, thereby providing insights
into neuroprotection and consolidated theories for future clinical application of EVs.

Conclusion:

EVs participate in an extremely wide range of cell activities, play a critical role in cell communication
centring neurons, and are considered potential therapies and biomarkers for SCI. miRNAs are
the most abundant nucleic acids shipped by EVs and effluent cytokines, and they may represent important
messengers of EVs and important factors in SCI treatment.
Antihypertensive and Vasorelaxant Effects of Hibiscus rosa-sinensis
through Angiotensin-Converting Enzyme-2 (ACE-2), and Ca2+ Channels
Pathways
Authors: Eddouks Mohamed , Amtaghri Smail , Amssayef Ayoub , Slaoui Miloudia
Published: March 2022

Aims:

The aim of the study was to assess the antihypertensive activity of Hibiscus rosa-sinensis.

Background:

Hibiscus rosa-sinensis is used traditionally to treat hypertension.

Objective:

The goal of the study was to investigate the effect of the aqueous extract of Hibiscus rosa-sinensis flowers (AEHRS) on resting blood pressure in rats.

Material and Methods:

In the present study, AEHRS was prepared and its antihypertensive activity was evaluated using in vivo and in vitro studies. In the in vivo study, hypertensive and normotensive rats were treated by AEHRS (100 mg/kg) orally for 6 hours in the acute treatment and for 7 days in the subchronic treatment. Systolic, diastolic, and mean arterial blood pressure values and heart rate were then recorded using a tail cuff and a computer-assisted monitoring device. To assess the vasorelaxant activity of AEHRS, isolated thoracic aortic rings were suspended in a tissue bath and changes in tension were recorded using a data acquisition system. Potential pathways involved in the vasorelaxant activity were evaluated using several standard pharmacological agents.

Results:

The results indicated that repeated oral administration of AEHRS during 7 days lowered systolic, diastolic, and mean arterial blood pressure in hypertensive rats without affecting normotensive rats. Furthermore, the data revealed that AEHRS exerts vasorelaxant properties via an endothelium-independent pathway. More interestingly, the study demonstrates that the vasorelaxant capacity of AEHRS seems to be exerted through the stimulation of angiotensin-converting enzyme-2 (ACE-2) and the inhibition of Ca2+ channels pathway.

Conclusion:

The present study revealed that aqueous extract of Hibiscus rosa-sinensis has a significant antihypertensive activity and that its vasorelaxant effect may be mediated through stimulation of ACE-2, and inhibition of the Ca2+ channels.
Droop Control-Based Grid Forming Inverters with an Auxiliary Grid
Support Control for Frequency Regulation in a Low Voltage Microgrid
Authors: Mohanan Athira , Daniel Asha Elizabeth
Published: March 2022

Aim:

Improving the frequency regulation in a Low Voltage (LV) microgrid during grid
mode transition using Grid Forming Grid Support (GFGS) converters with inertia emulation.

Background:

The ever-increasing demand for energy and the depleting fossil fuels has increased the
proliferation of converter-fed Renewable Sources (RES) in the conventional grid. The reduced system
inertia results in frequency regulation issues which are further aggravated by the unpredictable
nature of RES and dynamic switching of loads. This scenario results in blackouts, unwanted load
shedding, power quality issues, and discrepancies in protection schemes.

Objective:

A control scheme is presented on the principle of swing equation-based synchronization
to regulate the active power output of a grid-tied voltage-source converter operating in a grid forming
grid supporting mode in a low voltage PV-based microgrid. The Virtual Synchronous Machine
control (VSM) is implemented for controlling the active power output, which follows the grid frequency
deviations, ensuring the safe State of Charge (SoC) limits of the Battery Energy Storage
System (BESS).

Methods:

The stability issues due to the absence of inertia in an inverter-fed LV microgrid are
staved off by giving auxiliary grid support by implementing VSM control in a BESS inverter in the
grid forming mode. The LV microgrid model with all the converters in the GFGS converter is developed
in the MATLAB/Simulink environment. Particle Swarm Optimization (PSO) is used to fine-
tune the control parameters. The effectiveness of the control strategy has been investigated for
unintentional islanding events.

Results:

The droop control-based GFGS grid-tied converters with power balance equation-based
VSM control gave frequency regulation within the range stipulated by the grid codes during the islanding
events.

Conclusion:

The work demonstrates the effectiveness of VSM control in providing the auxiliary
grid support for droop-based grid forming converters in an LV microgrid.
The Investigation of Carrier Mobility Effect on the Performance Characteristics
of the InGaN-Based Vertical Cavity Surface Emitting Laser
(VCSEL) by Solving the Rate Equations
Authors: Goharrizi Azita Zandi , Alahyarizadeh Ghasem
Published: March 2022

Background:

Among the parameters that play an important role in describing the performance
of many devices is carrier mobility which is a criterion for the easy movement in semiconductor
crystals.

Objective:

The effect of carrier mobility on the performance characteristics of InGaN quantum well
vertical-cavity surface-emitting laser was analytically investigated.

Methods:

By solving the Poisson’s equation, current density equation, charge concentration continuity
equation and carrier and photon rate equations, the variation of current density and carrier density with
respect to the position and time and the effects of carrier mobility and temperature on these parameters
were investigated. Furthermore, the effect of mobility on the variation of output power versus the injection
current and on the time variation of photon and carrier density and the output power was investigated.

Results:

By increasing the carrier mobility, the threshold current is reduced and the output power is
increased. In studying the effect of temperature on the desired parameters, the variation of carrier density
with respect to time and position was affected by the temperature change. This phenomenon is due
to the dependence of these parameters on the diffusion coefficients and consequently on the mobility
of the carriers and the dependence of mobility on temperature.

Conclusions:

The output power increased, and the time delay in accruing the laser decreased. Consequently,
the carrier recombination increased, further resulting in a rapid laser operation.
WITHDRAWN: Preliminary Results of the Combined BlockACE2® Prevention
and BlockACE2® Functional food Scheme for the Prevention of COVID-19 in Working
Population. Clinical Trial, Controlled, Randomized, Triple-Blind, Phase II
Authors: Aristizabal-B Beatriz H. , Aristizabal-B Clara I. , Agudelo-J Bernardo , Gomez- O Luis Miguel , Cano-R Luz Elena , Lopez-M Beatriz Estella , Saldarriaga-F Juan Fernando , Rincon-C Olga L.
Published: March 2022

The article has been withdrawn at the request of the editor of the journal Applied Drug Research, Clinical Trials and Regulatory
Affairs.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham Science Disclaimer:

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of their article is transferred to the publishers if and when the article is accepted for publication.
Impact of the COVID-19 Pandemic Measures on the Number of Meals and the Types of Physical Activity of Adolescents: Cross-Sectional Study in Delhi, India
Authors:   Health Promotion Division, Public Health Foundation of India, Gurgaon, India, Rawal Tina ,   Department of Family Medicine, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands, Muris Jean W.M. ,   Department of Family Medicine, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands, Mishra Vijay Kumar ,   Health Promotion Division, Public Health Foundation of India, Gurgaon, India, Arora Monika ,   Health Promotion Division, Public Health Foundation of India, Gurgaon, India, Tandon Nikhil ,   Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India, Schayck Onno C.P. van ,   Department of Family Medicine, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands
Published: March 2022

COVID-19 greatly affected the lives of adolescents through restrictions such as less playtime, more screen time, and limited interaction with peers. In this study, we assessed the impact of the COVID-19 pandemic on the dietary and physical activity-related behavior of school students aged 10–16 years. This cross-sectional study was conducted with adolescents recruited from seven randomly selected private schools in Delhi, India, during 2021. A self-administered web-based survey was conducted to evaluate the behavior of the participants before and during the pandemic. Of the 512 students (53% males) who participated in the survey, 39% gained weight during the COVID-19 pandemic. There was a significant increase in the number of meals per day (p = 0.005) and a reduction in physical activity (p = 0.00) compared to the situation before the pandemic. The percentage of students who played indoor board and computer games increased from 13% to 46%. Students’s gender (p = 0.007) and parents’ education (mother: p = 0.003; father: p = 0.025) were significantly associated with physical activity during the pandemic. Higher socioeconomic status was significantly associated with consumption of more than two meals per day. The students who had working fathers with advanced/professional degrees were three times more likely [AOR 3.24, 95% CI (0.91–11.53)] to be physically active and eat a minimum of three major meals per day [AOR 3.21, 95% CI (1.77–5.81)] during the pandemic compared to those whose fathers were unemployed. This study highlighted the need for innovative strategies for adolescents and parents to adopt and practice a healthy lifestyle, especially during public health crises, such as the COVID-19 pandemic.
SciKit Digital Health: Python Package for Streamlined Wearable Inertial Sensor Data Processing
Authors: Adamowicz Lukas , Christakis Yiorgos , Czech Matthew D , Adamusiak Tomasz
Published: March 2022

Wearable inertial sensors are providing enhanced insight into patient mobility and health. Significant research efforts have focused on wearable algorithm design and deployment in both research and clinical settings; however, open-source, general-purpose software tools for processing various activities of daily living are relatively scarce. Furthermore, few studies include code for replication or off-the-shelf software packages. In this work, we introduce SciKit Digital Health (SKDH), a Python software package (Python Software Foundation) containing various algorithms for deriving clinical features of gait, sit to stand, physical activity, and sleep, wrapped in an easily extensible framework. SKDH combines data ingestion, preprocessing, and data analysis methods geared toward modern data science workflows and streamlines the generation of digital endpoints in “good practice” environments by combining all the necessary data processing steps in a single pipeline. Our package simplifies the construction of new data processing pipelines and promotes reproducibility by following a convention over configuration approach, standardizing most settings on physiologically reasonable defaults in healthy adult populations or those with mild impairment. SKDH is open source, as well as free to use and extend under a permissive Massachusetts Institute of Technology license, and is available from GitHub (PfizerRD/scikit-digital-health), the Python Package Index, and the conda-forge channel of Anaconda.
eHealth Literacy in a Sample of South Asian Adults in Edmonton, Alberta, Canada: Subanalysis of a 2014 Community-Based Survey (Preprint)
Authors: Makowsky Mark J , Davachi Shahnaz , Jones Charlotte A
Published: March 2022

BACKGROUND

Digital health interventions are efficient and flexible methods for enhancing the prevention and management of cardiovascular disease and type 2 diabetes. However, little is known about the characteristics associated with eHealth literacy in the Canadian South Asian population.

OBJECTIVE

The aim of this study is to describe perceived eHealth literacy and explore the extent to which it is associated with sociodemographic, health status, and technology use variables in a subset of South Asian Canadians.

METHODS

We analyzed data from the e-Patient Project survey, a mixed-mode cross-sectional survey that occurred in 2014. The eHealth Literacy Scale (eHEALS) was used to measure eHealth literacy in a convenience sample of 511 English- or Punjabi-speaking South Asian adults recruited from a community pharmacy, a family physician office, and community events in Edmonton, Alberta. Multivariable quantile regression was used to explore variables associated with eHealth literacy.

RESULTS

The analysis was restricted to 301 internet users (mean age 39.9, SD 14.8 years; 166/301, 55.1% female) who provided responses to all 8 eHEALS questions and complete demographic information. The mean overall eHEALS score was 29.3 (SD 6.8) out of 40, and 71.4% (215/301) agreed to at least 5 out of the 8 eHEALS items. The eHEALS item with the lowest level of agreement was “I can tell high-quality health resources from low-quality health resources on the internet” (182/301, 60.5%). Although there were statistically significant differences in eHEALS scores according to age, educational achievement, language preference, and the presence of chronic medical conditions, multivariable regression analysis indicated that language preference was the only variable independently associated with eHealth literacy (coefficient –6.0, 95% CI –9.61 to –2.39).

CONCLUSIONS

In our sample of South Asian Canadian internet users, preference for written health information in languages other than English was associated with lower eHealth literacy. Opportunities exist to improve eHealth literacy using culturally and linguistically tailored interventions.

CLINICALTRIAL
Pilot Results of a Digital Hypertension Self-management Program Among Adults With Excess Body Weight: Single-Arm Nonrandomized Trial (Preprint)
Authors: Wilson-Anumudu Folasade , Quan Ryan , Cerrada Christian , Juusola Jessie , Castro Sweet Cynthia , Bradner Jasik Carolyn , Turken Michael
Published: March 2022

BACKGROUND

Home-measured blood pressure (HMBP) in combination with comprehensive medication support and lifestyle change are the mainstays of evidence-based hypertension (HTN) management. To date, the precise components needed for effective HTN self-management programs have yet to be defined, and access to multicomponent targeted support for HTN management that include telemonitoring remain inaccessible and costly.

OBJECTIVE

The aim of this pilot study was to evaluate the impact of a digital HTN self-management program on blood pressure (BP) control among adults with excess body weight.

METHODS

A single-arm, nonrandomized trial was performed to evaluate a digital HTN self-management program that combines comprehensive lifestyle counseling with HTN education, guided HMBP, support for taking medications, and led by either a registered nurse or certified diabetes care and education specialist. A sample of 151 participants were recruited using a web-based research platform (Achievement Studies, Evidation Health Inc). The primary outcome was change in systolic BP from baseline to 3 months, and secondary outcomes included change in diastolic BP and medication adherence.

RESULTS

Participants’ mean age was 44.0 (SD 9.3) years and mean BP was 139/85 mm Hg. At follow-up, systolic and diastolic BP decreased by 7 mm Hg (P<.001, 95% CI –9.3 to –4.7) and 4.7 mm Hg (P<.001, 95% CI –6.3 to –3.2), respectively. Participants who started with baseline BP at goal remained at goal. For participants with stage 1 HTN, systolic and diastolic BP decreased by 3.6 mm Hg (P=.09, 95% CI –7.8 to 0.6) and 2.5 mm Hg (P=.03, 95% CI –4.9 to –0.3). Systolic and diastolic BP decreased by 10.3 mm Hg (P<.001, 95% CI –13.4 to –7.1) and 6.5 mm Hg (P<.001, 95% CI –8.6 to –4.4), respectively, for participants with stage 2 HTN. Medication adherence significantly improved (P=.02).

CONCLUSIONS

This pilot study provides initial evidence that a digital HTN self-management program improves BP and medication adherence.
Content Analysis of Nicotine Poisoning (Nic Sick) Videos on TikTok: Retrospective Observational Infodemiology Study (Preprint)
Authors: Purushothaman Vidya , McMann Tiana , Nali Matthew , Li Zhuoran , Cuomo Raphael , Mackey Tim K
Published: March 2022

BACKGROUND

TikTok is a microvideo social media platform currently experiencing rapid growth and with 60% of its monthly users between the ages of 16 and 24 years. Increased exposure to e-cigarette content on social media may influence patterns of use, including the risk of overconsumption and possible nicotine poisoning, when users engage in trending challenges online. However, there is limited research assessing the characteristics of nicotine poisoning–related content posted on social media.

OBJECTIVE

We aimed to assess the characteristics of content on TikTok that is associated with a popular nicotine poisoning–related hashtag.

METHODS

We collected TikTok posts associated with the hashtag #nicsick, using a Python programming package (Selenium) and used an inductive coding approach to analyze video content and characteristics of interest. Videos were manually annotated to generate a codebook of the nicotine sickness–related themes. Statistical analysis was used to compare user engagement characteristics and video length in content with and without active nicotine sickness TikTok topics.

RESULTS

A total of 132 TikTok videos associated with the hashtag #nicsick were manually coded, with 52.3% (69/132) identified as discussing firsthand and secondhand reports of suspected nicotine poisoning symptoms and experiences. More than one-third of nicotine poisoning–related content (26/69, 37.68%) portrayed active vaping by users, which included content with vaping behavior such as vaping tricks and overconsumption, and 43% (30/69) of recorded users self-reported experiencing nicotine sickness, poisoning, or adverse events such as vomiting following nicotine consumption. The average follower count of users posting content related to nicotine sickness was significantly higher than that for users posting content unrelated to nicotine sickness (W=2350.5, P=.03).

CONCLUSIONS

TikTok users openly discuss experiences, both firsthand and secondhand, with nicotine adverse events via the #nicsick hashtag including reports of overconsumption resulting in sickness. These study results suggest that there is a need to assess the utility of digital surveillance on emerging social media platforms for vaping adverse events, particularly on sites popular among youth and young adults. As vaping product use-patterns continue to evolve, digital adverse event detection likely represents an important tool to supplement traditional methods of public health surveillance (such as poison control center prevalence numbers).
Attention to socio-organisational dimensions is key to advancing the shared care record agenda in health and social care (Preprint)
Authors: Cresswell Kathrin , Anderson Stuart , Mozaffar Hajar , Elizondo Andrey , Geiger Marcia , Williams Robin
Published: March 2022

UNSTRUCTURED

We here discuss ways to tackle the grand challenge of integrating health and social care delivery with the help of digital technologies. We argue that previous attempts have largely failed to achieve their objectives due to implementers and decision makers not paying sufficient attention to the complex socio-organizational dimensions of change associated with initiatives. We provide an overview of which dimensions need to be considered and hope that these will help to inform strategic decisions going forward, thereby contributing to maximizing the chances of successful initiatives.
Young people’s trust in co-created online resources to promote mental health literacy: Qualitative study (Preprint)
Authors: Ito-Jaeger Sachiyo , Perez Vallejos Elvira , Logathasan Saruka , Curran Thomas , Crawford Paul
Published: March 2022

BACKGROUND

There is a pressing need to create resources to promote mental health literacy among young people. Digital media is one of the methods which can successfully promote mental health literacy. While digital mental health resources are generally favourably perceived by young people, one of the essential factors in whether they choose to use these interventions is trust.

OBJECTIVE

The objective of the present study was to explore young people’s trust-related concerns about and recommendations for the co-created mental health website by using TrustScapes. Our aim is to use the findings to improve the trustworthiness of the website and to inform future creators of online mental health resources.

METHODS

Thirty young people (M = 19.00, SD = 1.509, range = 17-21) participated in TrustScapes focus groups. Thematic analysis was applied to analyse both the TrustScapes worksheets and audio transcripts.

RESULTS

The qualitative analysis revealed that the mental health website contains elements perceived to be both trustworthy and untrustworthy by young people. The relatable and high-quality design, which was achieved by co-creating the website with a team of design professionals and young people, were considered to increase trust. Creators’ credibility also positively affected trust, but the logos and other information about the creators were recommended to be more salient for users. Suggestions were made to update the privacy policy and cookie settings and include communication functions on the platform to improve the trustworthiness of the website.

CONCLUSIONS

Factors perceived to be trustworthy included the relatable, high-quality design and creators’ credibility whilst those perceived to be untrustworthy included the privacy policy and cookie settings. The findings highlighted the significance of collaborating with end-users and industrial partners as well as the importance of making the trust enabling factors salient for users. We hope that such findings will inform future creators of online mental health resources to make them as trustworthy and effective as possible.
Meio século depois, a personalidade autoritária permanece relevante
Authors: Schargel Sergio
Published: March 2022

Resenha de:ADORNO, Theodor W. et al. Estudos sobre a personalidade autoritária. São Paulo: Editora Unesp, 2019.
Ensino de História em tempos de pandemia: percepções e narrativas de estudantes da Educação Básica de Goiás, Brasil
Authors: Nicolini Cristiano , Silva Maria da Conceição
Published: March 2022

Para suprir a necessidade de escolarização durante a pandemia da Covid-19, os estudantes passaram a ter aulas no formato virtual e a enfrentar uma série de inquietações no processo de aprendizagem. Pensando nisso, passamos a desenvolver uma investigação com estudantes da Educação Básica do Estado de Goiás, Brasil, para captar as percepções e narrativas produzidas durante esse período de suspensão das aulas presenciais no componente curricular de História. A partir de resultados prévios, apresentamos uma análise a partir da perspectiva da Educação Histórica, mais especificamente através dos conceitos de aprendizagem e consciência histórica.
O Ensino de História na Era Digital: Os Games Para Além da Gamificação
Authors: Grzybowski Lukas Gabriel
Published: March 2022

O presente artigo realiza uma reflexão em torno das possibilidades do emprego de jogos eletrônicos no ensino de história no nível básico. O artigo parte de reflexões teóricas quanto ao papel da educação, à teoria da história e seu ensino, aos jogos eletrônicos na sociedade contemporânea e as possibilidades de seu emprego no contexto educacional. Em seguida é apresentado de maneira suscinta um estudo de caso desenvolvido através de duas disciplinas-oficinas ministradas pelo autor. Os resultados apontam para a importância de se ampliar a reflexão em torno do emprego de jogos eletrônicos no ensino de história, de se traçar estratégias para tanto, e de se repensar o ensino de história na Era Digital.
Stimulating the Innovative Development of the Regions of the Russian Federation within the Framework of Strategic Investment Projects
Authors: Perminova E. A.
Published: March 2022

The present study is aimed at forming proposals to stimulate accelerated innovative development of the regions of the Russian Federation in the conditions of increasing global crises associated with the influence of the unstable international situation in connection with the events in Ukraine and the introduction, as well as the prospect of sanctions against the Russian Federation, as well as the impact on both the world and the Russian economy of the consequences of significant restrictions due to the situation with coronavirus.

Aim. Formation of proposals for accelerated innovative development of the regions of the Russian Federation based on the use of strategic investment projects in the conditions of reconstruction of territorial production complexes, which will form the prerequisites for the advanced development of the regions.

Tasks. To consider approaches to stimulating accelerated innovative development of the regions of the Russian Federation and its assessment based on: the use of key performance indicators; diversification of the economic potential of the regions, as well as the use of venture financing; introduction of the concepts of strategic investment projects and strategic investment initiatives into strategic regional development programs; the use of the theory of the territorial-industrial complex in modern economic conditions.

Methods. In this paper, using the methods of factorial, statistical and quantitative analysis, proposals have been developed for the formation of measures to achieve maximum success in the innovative development of advanced industries in the regions of the Russian Federation.

Results. The study showed that in order to achieve the objectives of accelerated innovative development of the regions of the Russian Federation, when forming strategic planning documents, it is necessary to focus on the main “development complexes”, participation in the implementation of a new model of economic growth based on the prin ciples of public-private partnership based on a comprehensive theoretical and methodological approach to the formation of socio-economic policy and the active use of strategic investment projects.

Conclusions. It is advisable in the strategic programs of the regions to determine the creation of hightech innovative projects for processing raw materials available on the territory in order to get out of the dependence of the economy on raw materials; to create the necessary conditions for improving the investment climate in order to attract high-tech projects of leading world states for their further use in their own needs; actively diversify existing own high-tech projects in order to maximize profits and create an image of a highly developed, competitive region; create high-tech divisions on the basis of financial and economic institutions to launch and finance innovative, knowledge-intensive projects with a view to their further diversification and integration both in the region and with third entities.
La ética en la enseñanza: Práctica e investigación en psicología
Authors: Coffin Cabrera Norma , Yoseff Bernal Juan José , Jiménez Rentería María de Lourdes , Cedillo Ildefonso Benita , Anguiano Serrano Sandra Angélica
Published: March 2022

En una sociedad convulsionada por la pobreza, el crimen organizado, la corrupción generalizada, los feminicidios, el acoso sexual y laboral, así como la falta de credibilidad en las instituciones de todo tipo, pareciera que la única salida es “sálvese quien pueda”. No obstante, un panorama tan desolador como el que vive la población mexicana, en particular ante la pérdida de los valores fundamentales para la vida y la sana convivencia entre los individuos, existen instituciones y colectivos que de manera tenaz luchan por recuperar los valores y la ética perdida a lo largo del tiempo y por circunstancias diversas. Una de estas instituciones es la Universidad Nacional Autónoma de México, cuyo compromiso social va más allá de la formación de profesionales altamente capacitados. Su tarea educativa impulsa la formación integral de los futuros profesionales buscando que en aulas y espacios de convivencia universitaria se viva cotidianamente bajo principios y valores éticos. Este libro es una invitación a reflexionar acerca del vínculo entre moral, ética y derechos humanos; respecto a la tendencia actual a imponer valores de unas sociedades sobre otras, perdiendo así la diversidad que nos caracteriza como especie y nos enriquece culturalmente; invita al análisis de la importancia que tienen la moral y ética personal para el ejercicio profesional en la disciplina psicológica, donde siempre está involucrado el otro u otros individuos, cuyos valores pueden ser diametralmente opuestos a los del profesional que los atiende. ¿Cómo desarrollar un ejercicio profesional ético? ¿Hay alguna normatividad que se exija cumplir al profesional de la psicología? ¿A qué dilemas éticos nos enfrentamos? Estas y otras interrogantes se plantean al lector y se proporcionan algunas guías para resolverlas. Este libro es el esfuerzo de académicos que pertenecen o pertenecieron al subcomité de ética de la carrera de Psicología de la FES Iztacala; se elaboró con la intención de impulsar el conocimiento de la ética en nuestra comunidad universitaria y constituirse en un documento de apoyo para la enseñanza de la ética que, para fortuna de todos, permea tanto vertical como horizontalmente el plan de estudios de la carrera.
MUJERES Y PENALIDAD EN EL DEVENIR HISTÓRICO: PRÁCTICAS DE VIGILANCIA, CASTIGO Y RECLUSIÓN FEMENINA EN EL TERRITORIO ARGENTINO ENTRE FINALES DEL SIGLO XVI Y MEDIADOS DEL XX
Authors: Actis María Florencia
Published: March 2022

El artículo repasa los motivos y mecanismos punitivos destinados a las mujeres, y desplegados en el territorio de la actual Argentina desde el sistema de Tribunales y Comisariados Inquisitoriales en América hasta la década de 1970. Pero fundamentalmente analiza, desde un enfoque crítico y apoyado en investigaciones feministas interdisciplinarias, los modos en que el pensamiento penal se ha constituido sobre criterios de selectividad sexual y formas masculinizadas de poder, produciendo cierta distribución de la vulnerabilidad social que ha afectado, de manera desigual y perdurable hasta nuestros días, a las mujeres pobres, vistas como transgresoras de su género.
Valuation of foundry sand in the construction sector.
Authors:   University of Tiaret, Belmahi Samir ,   Geomatics and sustainable development laboratory,Tiaret-Algeria., Mohamed Zidour ,   University of Tiaret; Geomatics and sustainable development laboratory,Tiaret-Algeria., Abdelkader Haddi ,   University of Artois. Faculty of Applied Sciences, LGCgE laboratory, Béthune, France
Published: March 2022

The purpose of this work is to find out the possibility of valorizing the green foundry sand from the foundry of EPE-ALFE, Tiaret, Algeria in construction. Mortars which are based on this sand were made and their mechanical behavior was evaluated. The first results showed that the strengths of these mortars represent approximately 74% to 80% of the resistance of the control mortar based on quarry sand from Guelta, Algeria, so, the mixture of 30 to 50% of quarry sand with the Foundry green molding sand increases this interval and gives an ordinary mortar with compressive strengths varying between 25 and 30 MPa which allows an extended use of this sand meeting the 206.1 standard of concrete. This solution represents an economic choice in construction which makes it possible to recycle around 50% of the quantity of foundry sand for any concrete production and it will help with the elimination of waste and the rapid release of storage areas at the level of foundries as well meet the requirements of the quality assurance plan.
Factors affecting post-fire, vitality and recovery of cork oak trees in Yifri forest (NorthWest of Algeria).
Authors:   Department of Forestry Resources, Conservatory Management of Water, Soil and Forests Laboratory, University of Tlemcen, BP88, Mansourah ,13000 Tlemcen, Algeria, Bouazzaoui Ayyoub , Tarik Bouhraoua Rachid ,   Department of Forestry Resources, Conservatory Management of Water, Soil and Forests Laboratory, University of Tlemcen, BP88, Mansourah ,13000 Tlemcen, Algeria, Ghefar Mohammed ,   National Institute for Forest Research, BP 07, Sidi Bel Abbes 22000, Algeria
Published: March 2022

The cork oak (Quercus suber L.) is a fire-adapted species due to the protection of dormant buds located under its cork bark. Post-fire resprouting in trees from these buds is an efficient means of plant adaptation. In this study, we examined the different types of the response of 644 trees, one year after a wildfire occurred in summer 2012 in the Tlemcen area. Furthermore, we determined the variables influencing the vitality likelihood of trees using multiple logistic regression. The dominant response is crown resprouting (67.7%), followed by tree death (23.9%) and basal resprouting (8.4%). The probability of tree vitality decreased with increasing fire intensity which associated with the importance of trunk injuries, decreasing bark thickness and tree height. This model is an interesting tool for diagnosing tree mortality or survival to assess the ecological and economic restoration actions for the forest.
Factors affecting the attitude toward mobile commerce usage among Lebanese consumers: A conceptual Framework.
Authors:   ESA Business School, Department of Business Administration Beirut, Lebanon, Bou Khzam Haifa , Francois Lemoine Jean ,   University Paris 1 Pantheon-Sorbonne, Department of Management Paris, France
Published: March 2022

Mobile commerce is a worldwide innovation. However, in Lebanon, several factors are hindering its development. Therefore, our objective is to find the factors influencing the consumer’s attitude toward the use of mobile commerce and to create a research model reflecting our findings. This research revises the basic theories of technology adoption and studies conducted in m-commerce, e-commerce, and related fields. An exploratory study of deep interviews with 14 consumers and experts was held, and a content analysis by themes was performed to show the consistent variables for our conceptual framework. New derived variables, the situational factor and digital culture tend to moderate the relations between independent and dependent variables. Service availability, self-efficacy and social-influence significantly influence the consumer’s attitude toward the use of m-commerce, while cost is negatively affected. This study has both theoretical and managerial implications, it presents a new research model compared to prior studies in online service technologies, especially in mobile commerce. In addition, results provide online businesses with many trusted recommendations for their strategic plans based on analyzed and accurate data.
Analisis Faktor-Faktor Yang Mempengaruhi Vaccine hesitancy (Keragu-Raguan Vaksin) Pada Mahasiswa Di Era Pandemi Covid-19
Authors: Saida Saida , Zulfadhli Muhammad , Jurais Muh
Published: March 2022

Vaccine hesitancy dapat menghambat upaya pengendalian COVID-19. Menurut IPI dan CSIS, tingkat vaccine hesitancy cukup tinggi di kalangan generasi muda, sehingga diperlukan strategi yang tepat untuk meningkatkan penerimaan dan mengurangi vaccine hesitancy. Oleh karena itu, penelitian ini bertujuan untuk mengidentifikasi faktor-faktor yang mempengaruhi tingkat vaccine hesitancy mahasiswa. Kami menggunakan data dari hasil survei online terhadap mahasiswa di Makassar. Analisis deskriptif terhadap 384 mahasiswa didapatkan bahwa tingkat vaccine hesitancy cukup tinggi yaitu 54,55% mahasiswa masih akan menunda vaksinasi, bahkan ditemukan 10,13% mahasiswa menolak/tidak menginginkan vaksin sama sekali. Beberapa faktor yang berpengaruh secara signifikan diantaranya kebijakan pemerintah dalam pengambilan keputusan terkait vaksinasi, hambatan geografis, pengalaman vaksinasi masa lalu, kepercayaan dan sikap tentang kesehatan, pengetahuan dan wawasan, kepercayaan dan pengalaman pribadi terhadap sistem dan layanan kesehatan, serta risiko/manfaat (bukti epidemiologis dan ilmiah).
Earnings management and asymmetric sensitivity of bonus compensation to earnings for high-growth firms
Authors: Kwon Sung S. , Gélinas Patrice , Waweru Nelson
Published: March 2022

In this paper, we examine whether high-IOS (investment opportunity set) firms vis-à-vis non-growth (low-IOS) firms will not reduce discretionary expenditures, such as advertising expenses, research and development, and SG&A (selling, general and administrative) expenses, to further sustain the firm growth in a more conservative reporting environment (the post-Sarbanes-Oxley (SOX) period). We also investigate, as an extension of a prior paper, the sensitivity of CEO bonuses to earnings in the cases of high-IOS and low-IOS firms. We find a stronger association between incentive compensation and asymmetric sensitivity of bonus to earnings for high-IOS firms in the pre-SOX period, and this asymmetric sensitivity disappears even for high-IOS in the post-SOX period. As in a prior study, we also look into whether accounting conservatism is stronger in the post-SOX period for both high-IOS and low-IOS firms than in the pre-SOX period. The findings are consistent with our hypotheses that high-IOS firms vis-à-vis low-IOS firms will not reduce discretionary expenditures, asymmetric sensitivity bonus to earnings disappears in the post-SOX period for both high-IOS and low-IOS firms, and that accounting conservatism for both high-IOS and low-IOS firms are stronger in the post-SOX period. The documented evidence in this study shows how regulatory changes affect both accrual and real earnings management behaviors, how those regulatory changes affect the sensitivity of bonus compensation to earnings, and how accounting conservatism affects bonus compensation changes in the post-SOX period in relation to the pre-SOX period for both high-IOS and low-IOS firms
Three-step iterative weight function scheme with memory for solving nonlinear problems
Authors: Cordero Alicia , Garrido Neus , Torregrosa Juan Ramon , Triguero-Navarro Paula
Published: March 2022

In this manuscript,we present a parametric family of derivative-free
3-steps iterative methods with a weight function for solving nonlinear
equations. We study various ways of introducing memory to this
parametric family in order to increase the order of convergence without
new functional evaluations. We also performed numerical experiments to
compare the iterative methods fromdifferent points of view.
Delayed, Recurrent Bile Leak from Isolated Right Posterior Sectoral Duct Injury After Laparoscopic Cholecystectomy: An Unusual Presentation
Authors: Sharma Amit , Ruch Brianna , Alwatari Yahya , Lele Sonia , BouHaida Doumit
Published: March 2022

Bile leak after cholecystectomy is associated with significant
comorbidity. Biliary duct variant anatomy can complicate identification
and management. We report a rare presentation of recurrent delayed leaks
years after laparoscopic cholecystectomy secondary to missed right
posterior sector bile duct injury. Surgical intervention was required
after failure of conservative management
Feasibility study of oxidized naringin as a novel crosslinking agent for crosslinking decellularized porcine Achilles tendon and its potential application for anterior cruciate ligament repair
Authors: Cheng Can , Peng Xu , Xi Linjie , Luo Yihao , Wang Yuhang , Zhou Yufan , Yu Xixun
Published: March 2022

Naringin (Nar), a natural flavanone glycoside, has been shown to possess
a variety of biological activities, including anti-inflammatory,
anti-apoptotic and bone formation, etc. In this study, Nar was oxidized
by sodium periodate and the oxidized naringin (ONar) was used as a novel
biological crosslinking agent. And ONar-fixed porcine decellularized
Achilles tendon (DAT) was developed to substitute anterior cruciate
ligament (ACL) for researching a novel ACL replacement materials. The
ONar with a 24 h oxidation time had appropriate aldehyde group content,
almost no cytotoxicity, and a good crosslinking effect. The critical
characteristics and cytocompatibility of ONar-fixed DAT were also
investigated. The results demonstrated that 1% ONar-fixed DAT exhibited
good resistance to enzymatic degradation and thermal stability as well
as suitable mechanical strength. Moreover, 1% ONar-fixed specimens
exhibited excellent L929 fibroblasts-cytocompatibility and
MC3T3-E1-cytocompatibility. They also promoted the secretion of
hepatocyte growth factor (HGF) and basic fibroblast growth factor (bFGF)
from fibroblasts and bone morphogenetic protein-2 (BMP-2) from
osteoblasts. And they also showed the good anti-inflammatory properties
in vivo experiments. Our data provided an experimental basis for ONar as
a new cross-linking reagent in chemical modification of DAT and
ONar-fixed DAT for ACL repair.
Oplus-Essential Supplemented Modules
Authors: Nebiyev Celil , Ökten Hasan Hüseyin
Published: March 2022

In this work oplus-e-supplemented modules are defined and some
properties of these modules are investigated. It is proved that the
finite direct sum of oplus-e-supplemented modules is also
oplus-e-supplemented. Let M be a distributive and oplus-e-supplemented
R-module. Then every factor module and homomorphic image of M are
oplus-e-supplemented. Let M be a oplus-e-supplemented R-module with SSP
property. Then every direct summand of M is oplus-e-supplemented.
Fungal endophytes help grasses to tolerate sap-sucking herbivores through a hormone signaling system
Authors: he yali , Chen Taixiang , Zhang Haijuan , White James , Li Chunjie
Published: March 2022

Background: Plants possess a sophisticated hormone signaling system,
which includes salicylic acid (SA) and jasmonic acid (JA), to defend
itself from herbivores. In addition, this immune system is modulated by
nonpathogenic microbes that live asymptomatically within intercellular
spaces of host grasses. We investigated the resistance triggered by
defense hormones, and that provided by endophyte Epichloë gansuensis
against aphid Rhopalosiphum padi, and how the endophyte regulates this
tripartite interaction. Methods: Achnatherum inebrians plants, with and
without the fungal endophyte Epichloё gansuensis, were grown in the
greenhouse of the College of Pasture Agriculture Science and Technology,
Yuzhong campus of Lanzhou University (temperature: 24±2 °C, moisture:
76±2% photoperiod:L16:D8 h), were subjected to exogenous application of
SA (5 mM, 10 mM, 15 mM) and aphid Rhopalosiphum padi infestation (5
A./plant, 10 A./plant, 15 A./plant). Result: Endophyte induced plant
tolerance to the aphid feeding and exogenous SA increased plant shoot
biomass, root biomass, plant length and chlorophyll content. Endophyte
colonization induces WRKY54 factor that overrides negative effects on
plant growth and possibly suppresses SA accumulation. In addition, the
endophyte promotes a level of JA that is antagonistic to the SA pathway.
By disabling the SA mechanism for herbivore-mediated plant growth
inhibition, the endophyte induces plant tolerance to herbivory.