bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of empathy on work alienation among Chinese nurses during the COVID-19 pandemic: The mediating effect of ego depletion
Authors: Cui Yi , Yang Tianqi , Zhang Man , Liu Na , Liu Qin , Zhang Lanfang , Zhang Lihua , Yang Haoshuang , Zhang Yinling
Published: February 2023

Background

Nurses’ work alienation has become increasingly serious due to the increase in workload and risk during the coronavirus disease 2019 (COVID-19). However, no studies have investigated the link between empathy, ego depletion, and work alienation among Chinese nurses. The present study aimed to evaluate Chinese nurses’ empathy, ego depletion, and work alienation and to examine whether nurses’ ego depletion mediates the relationship between empathy and work alienation.

Methods

This was a descriptive, cross-sectional study involving 353 nurses from Shaanxi. The Jefferson Scale of Empathy-Health Professionals, Self-Regulating Fatigue Scale and Work Alienation Questionnaire were used to collect data through an online survey. Structural equation modeling was conducted to analyze the mediating model.

Results

Work alienation was negatively correlated with empathy (r = −0.305, p < 0.01) and positively correlated with ego depletion (r = 0.652, p < 0.01). Empathy was negatively correlated with ego depletion (r = −0.325, p < 0.01). Empathy can directly predict work alienation (β = −0.263, p < 0.01), while ego depletion has a mediating effect between empathy and work alienation (β = −0.309, p < 0.01), and the mediating effect accounts for 54.02% of the total effect.

Conclusion

Nurses’ work alienation was at a moderate-to-high level. Improving empathy can reduce work alienation through less ego depletion. Nursing managers should discover nurses’ work alienation as soon as possible. Interventions to improve empathy can help replenish nurses’ psychological resources, thereby reducing ego depletion and work alienation.
Patience and its relationship to stress tolerance in relation to demographic factors of the medical system in Bethlehem Governorate during the COVID-19 pandemic
Authors: Al-Arja Nahida Saba
Published: February 2023

Objective

The present study aims to identify the relationship between patience and stress tolerance in the medical system in Bethlehem Governorate during the COVID-19 pandemic, as well as to identify the impact of several demographic variables on it.

Methods

A random sample of 160 members/workers of the medical staff completed the Patience Scale and Coping Processes Scale questionnaire.

Results

It showed there is a significant positive effect for patience on stress tolerance and there were statistically significant differences in the level of patience in favor of males and single workers. It was also found that there is no difference in the specific duties of a health care worker and no variance of statistical evidence was found in the level of patience due to work with COVID patients but there were differences in stress tolerance in favor of those who do not work with COVID patients. It was also found that there is a significance in the level of stress tolerance in favor of the National Center in regard to bearing pressure. The study findings indicate there was a negative correlation with statistical significance between stress tolerance and age. The nature of stress changes with age, from episodic to chronic, which in turn affects appraisal and coping processes.

Conclusion

This study, which was conducted on a sample of Palestinian medical workers in the Bethlehem area, showed that at the beginning of the pandemic, the medical system in Palestine was not ready to handle COVID-19, and had no precautions to prevent the disease. In spite of that, the doctors and nurses who were undergoing psychological pressure were able to stand at the front line and face the outbreak of the coronavirus.
Association between olfactory dysfunction and mood disturbances with objective and subjective cognitive deficits in long-COVID
Authors: Llana Tania , Mendez Marta , Garces-Arilla Sara , Hidalgo Vanesa , Mendez-Lopez Magdalena , Juan M.-Carmen
Published: February 2023

Background and purpose

The coronavirus disease 2019 (COVID-19) has been associated with olfactory dysfunction. The persistent symptoms of anosmia or hyposmia were associated in previous studies with the development of memory impairment and mood disturbances. We aimed to investigate the association between the chronicity of reported olfactory dysfunction and subjective and objective cognitive performance in long-COVID patients and to explore whether their emotional symptoms are related to their cognition.

Methods

One hundred twenty-eight long-COVID participants were recruited. Reported symptomatology, subjective memory complaints, anxiety and depression symptomatology, and trait-anxiety were assessed. Subjective memory complaints and mood disturbances were compared among groups of participants with olfactory dysfunction as an acute (AOD), persistent (POD), or nonexistent (NOD) symptom. Seventy-six of the volunteers also participated in a face-to-face session to assess their objective performance on tests of general cognitive function and verbal declarative memory. Objective cognitive performance and mood disturbances were compared among the AOD, POD, and NOD groups.

Results

The subjective memory complaints and the anxiety and depression symptoms were similar among the groups, but the score in general cognitive function was lower in the participants with symptoms of acute olfactory dysfunction than in those with no olfactory symptoms at any time. Participants’ memory complaints were positively related to their emotional symptoms. The relationship between depressive symptomatology and memory complaints interacted with the olfactory dysfunction, as it only occurred in the participants without symptoms of olfactory dysfunction. Depressive symptomatology and acute olfactory symptoms were negatively associated with general cognitive function and delayed memory performance. The months elapsed from diagnosis to assessment also predicted delayed memory performance. Anxious symptomatology was negatively associated with the immediate ability to recall verbal information in participants who did not present olfactory dysfunction in the acute phase of the infection.

Conclusion

Olfactory dysfunction in the acute phase of the infection by COVID-19 is related to cognitive deficits in objective tests, and mood disturbances are associated with self-reported and objective memory. These findings may contribute to further understanding the neuropsychological and emotional aspects of long-COVID.
Cultural values and changes in happiness in 78 countries during the COVID-19 pandemic: An analysis of data from the World Happiness Reports
Authors: Rajkumar Ravi Philip
Published: February 2023

The concept of happiness is consistent across cultures to a significant extent, and encompasses both internal (subjective) and external (situational) aspects. Cultural values and norms shape emotions and behavior from an early age, and hence play a key role in influencing cross-national variations in happiness. Cross-national variations in culture can thus play a key role in influencing the relationship between adverse circumstances, such as the COVID-19 pandemic, and happiness. The current study examines the relationship between the six dimensions of culture, defined by Hofstede and his colleagues, and subjective ratings of happiness in 78 countries, obtained before (2017–19) and during (2020–21) the COVID-19 pandemic, based on data from the most recent World Happiness reports. The key results were: (a) countries were as likely to experience an increase as a decrease in self-reported happiness during this period; (b) distinct domains of culture were significantly correlated with happiness at each time point, though there was a certain degree of overlap; (c) pre-pandemic levels of happiness were negatively associated with changes in happiness during the pandemic; and (d) among cultural dimensions, long-term orientation was positively associated with changes in subjective happiness, while indulgence was negatively associated with this variable. Certain cultural values may play an important part in fostering a path to well-being in the face of stressful or traumatic circumstances. This path may be similar to the concept of mature happiness, derived from existential philosophy, which is characterized by achieving a balance between the positive and negative aspects of one’s life.
Can impoverished family nurture rich sons any more? The effect of household income on intergenerational transmission of education: Evidence from China
Authors: Li Xiaofan , Xie Weiwei , Wang Lu , Zou Tingting
Published: February 2023

Family investment in education is an important variable influencing the educational attainment of children. Family investment in education is influenced by family income, and the increase in family income gap will aggravate the inequity of education and enhance the degree of intergenerational transmission of education. But the above theories need to be further tested in reality. This paper uses the 2018 China Family Panel Studies (CFPS) to verify the role of Chinese family income on intergenerational transmission of education through the education transition matrix and the mediating effect model, and examines the effect of college expansion policy on the mediating effect of family income on intergenerational transmission of education. The results show that: (1) The education level of parents has obvious transmissibility to the education level of children. The solidification rate of intergenerational transmission of education between parents and children is 25.72%, the upward mobility rate is 60.58% and the downward mobility rate is 13.70%. (2) The mediating effect model shows that the total effect of the parents’ education level on children’s education level is 0.279 and the direct effect is 0.272, and the family income plays a mediating effect in the intergenerational transmission of education, and the mediating degree reaches about 2.6%. (3) The expansion of higher education provides more opportunities for children of society, especially lower-middle-income families, to receive higher education, which weakens the mediating effect of family income in the intergenerational transmission of education. The findings of this paper provide support for policymakers to increase public investment in education.
Homeland, emotions, and identity: Constructing the place attachment of young overseas Chinese relatives in the returned Vietnam-Chinese community
Authors: Shu Zhangwen , Du Yuan , Li Xuzhou
Published: February 2023

Little attention has been paid to the place attachment and homeland construction for refugees and their descendants in China. This study investigates the process by which the place attachment of Young Overseas Chinese Relatives is shaped in the context of resettlement sites. This qualitative research employed ethnographic fieldwork, and the author collected local literature and materials from February to December 2019 through participatory observation, in-depth interviews, and questionnaires. It is believed that the construction of a new homeland in the community, the emotional experience of the Young in childhood, and the cultural logic of place attachment shape place attachment. The process by which place attachment is shaped is interwoven with homeland construction, which indicates that the living state and mentality of the Young are becoming increasingly stable. The Young developed different mentalities on the basis of traditional Confucian culture in responding to the socio-cultural environments. The resettlement site has become a homeland to which young persons are solidly attached, people give this site meanings and experience certain emotions regarding it, which generates place identity and begins the process of homeland construction.
Exploring the comorbidity between personality and musculoskeletal disorders among adults: A scoping review
Authors: Quirk Shae E. , Koivumaa-Honkanen Heli , Kavanagh Bianca E. , Honkanen Risto J. , Heikkinen Jeremi , Williams Lana J.
Published: February 2023

Introduction

There is growing awareness of the comorbidity between mental and musculoskeletal disorders (MSDs) and their associated burden. We aimed to explore what is known regarding the existing epidemiological clinical–and population– based literature on the comorbidity between personality disorders (PDs) and MSDs specifically. In addition, we aimed to investigate their associated burden by examining a range of outcomes including morbidity/mortality, patient- and clinical-reported outcomes, work-related outcomes, hospital admissions, and financial costs. Finally, we sought to identify gaps in the literature and provide recommendations for further research.

Methods

Studies with participants 15 years of age were eligible. Categorical PDs/features (DSM-III/IV/5 or ICD 9/10), identified by a health care professional, medical records, diagnostic interviews, or self-administered questionnaires. The definitions/groupings of MSDs were guided by the ICD-10 including conditions of the back, joints, and soft tissue, and disorders of bone density and structure. Published peer-reviewed and gray literature were considered. Eligible study designs were cohort, case-control, and cross-sectional studies, and existing reviews of observational studies. Identification and selection of articles, data extraction and the presentation of the results was conducted according to the Joanna Briggs Institute methodological guidance and the PRISMA extension for scoping reviews.

Results

In total, 57 articles were eligible including 10 reviews and 47 individual studies. Across clinical and population settings, we detected evidence of comorbidity between PDs and chronic back/neck/spine conditions, arthritis, and fibromyalgia, and emerging evidence of associations between PDs and reduced bone mineral density. In terms of knowledge gaps, the burden associated with PDs and MSDs is poorly understood, as is their underlying mechanisms.

Discussion

This scoping review might prompt further research into PDs and MSDs as separate groups of disorders, along with their comorbidity and the mechanisms that may link them.

Systematic review registration

https://osf.io/mxbr2/registrations.
The effect of adding curcumin to sodium valproate in treatment of patients with bipolar disorder in the acute phase of mania: A randomized double-blind clinical trial
Authors: Akbarzadeh Farzad , Niksun Nabahat , Behravan Ghazal , Behdani Fatemeh , Mohammadpour Amir Hooshang , Jaafari Mahmoudreza , Hosseini Tayebeh , Rajai Zahra , Ebrahimi Alireza , Eslamzadeh Mahboubeh
Published: February 2023

Background

Inflammatory processes play a role in the etiopathogenesis of bipolar disorder type 1. Full therapeutic responses are seldom seen and the ongoing inflammatory processes in the brain could lead to neuronal loss. Curcumin, a relatively safe herbal compound, has been shown to have anti-inflammatory effects. The present randomized double-blind clinical trial study aimed to investigate the effect of adding curcumin to the treatment regimen of BID.

Materials and methods

This randomized double-blind clinical trial was conducted on 78 patients diagnosed with BID according to the Diagnostic and Statistical Manual of Mental Disorders (DSM 5) criteria. The sample were divided into two groups. Patients in both groups received sodium valproate starting at a dose of 600 milligrams per day and administered up to 20 milligrams per kilogram per day or the highest dosage of the patient’s tolerance. Patients in the intervention group also received curcumin as nanomicelle in soft gelatin capsules 40 milligrams per day. The control group received placebo tablets with the same characteristics as the curcumin tablets. They were assessed by a psychiatrist using the Young Mania Rating Scale (YMRS), Mini-Mental State Examination (MMSE), Clinical Global Impression (CGI), and a medication side effect questionnaire at the beginning of the study, as well as in the first, second, and fourth weeks of the study.

Results

Among the 78 patients chosen to participate in the project, 54 people completed the trial. No specific side effect was observed in the two groups. Both groups showed an increase in their MMSE scores compared to the beginning of the study (value of p < 0.001). Although this increase was not statistically different between the two groups (value of p = 0.68). The YMRS score of both groups decreased significantly by the end of the study (value of p < 0.001); however, this decrease was not significantly different between the two groups (value of p = 0.64). In addition, the two groups experienced a significant increase in their CGI scores throughout the study (value of p < 0.001), this increase however was not statistically different between the two groups (value of p = 0.88).

Conclusion

The present study suggested that curcumin may not be a useful adjuvant agent in the management of patients with BID receiving sodium valproate as treatment.

Clinical trial registration: Iranian Registry of Clinical Trials (IRCT), identifier IRCT2016102530504N1.
How do people with MND and caregivers experience a digital mental health intervention? A qualitative study
Authors: Pinto Cathryn , Geraghty Adam W. A. , Pagnini Francesco , Yardley Lucy , Dennison Laura
Published: February 2023

Objective

We urgently need to develop and evaluate more psychological interventions to support people with Motor Neurone Disease (MND) and caregivers. We used the person-based approach to develop a digital mental health intervention and conducted two studies to explore people’s experiences of using it.

Methods

In Study 1, we conducted think-aloud interviews with 9 people with MND and 8 caregivers, and used findings to refine the intervention. In Study 2, 18 people with MND and 9 caregivers used the intervention for 6 weeks after which in-depth interviews were conducted. Data from both studies were combined and analysed using thematic analysis.

Results

We developed 3 main themes around intervention acceptability, engagement, and usefulness. Participants highlighted the importance of accessibility and realistic presentation of information and support. Tailoring and timing intervention use to suit own needs, preferences, and disease stage was also important. Participants used the strategies presented to develop a positive outlook and regain some control. They also faced some challenges using these strategies in the context of dealing with progressive loss.

Conclusion

People with MND and caregivers can find digital mental health interventions useful. Intervention accessibility and flexibility are important for developing acceptable and engaging interventions for MND.
Co-prescription of aripiprazole on prolactin levels in long-term hospitalized chronic schizophrenic patients with co-morbid type 2 diabetes: A retrospective clinical study
Authors: Liu Xuebing , Sun Xianzhi , Li Lu , Zeng Kuan , Li Yi , Gao Yujun , Ma Jun
Published: February 2023

Background

One of the most frequent side effects of atypical antipsychotics is hyperprolactinemia (HPRL), and metformin or aripiprazole co-prescription is regarded as an effective therapy option for reducing prolactin (PRL) levels. However, whether either of the two drugs can reduce PRL levels in patients with long-term hospitalized chronic schizophrenia with co-morbid type 2 diabetes (T2DM) has not been adequately reported.

Methods

In our study, long-term hospitalized chronic schizophrenia patients with co-T2DM who were prescribed olanzapine or risperidone as the primary antipsychotic medication were enrolled. A total of 197 of these cases with co-prescribed aripiprazole were set up as the study group (co-Ari group), and the other 204 cases without co-prescribed aripiprazole were set up as the control group (non-Ari group). The two groups’ variations in each target parameter were compared, and the variables affecting PRL levels were examined.

Results

Compared to the non-Ari group, fasting blood glucose (FBG), blood uric acid (UA), total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) levels were significantly higher in the co-Ari group, but there was no difference in PRL levels. Co-prescribing aripiprazole had no impact on PRL levels in all patients with co-T2DM, and aripiprazole dose had no impact on PRL levels in the clinical subgroup of the co-Ari group.

Conclusion

Aripiprazole not only worsened the severity of index disturbances associated to metabolism in long-term hospitalized chronic schizophrenia patients with co-T2DM on metformin-based hypoglycemic medications but also failed to lower PRL levels.
A multinational survey of patient utilization of and value conveyed through virtual symptom triage and healthcare referral
Authors: Gellert George A. , Orzechowski Piotr M. , Price Tim , Kabat-Karabon Aleksandra , Jaszczak Jakub , Marcjasz Natalia , Mlodawska Agata , Kwiecien Aleksandra K. , Kurkiewicz Piotr
Published: February 2023

Objective

To describe the use patterns, impact and derived patient-user value of a mobile web-based virtual triage/symptom checker.

Methods

Online survey of 2,113 web-based patient-users of a virtual triage/symptom checker was completed over an 8-week period. Questions focused on triage and care objectives, pre- and post-triage care intent, frequency of use, value derived and satisfaction with virtual triage. Responses were analyzed and stratified to characterize patient-user pre-triage and post-triage intent relative to triage engine output.

Results

Seventy-eight percent of virtual triage users were female, and 37% were 18–24 years old or younger, 28% were 25–44, 16% were 45–54, and 19% were 55 years or older; 41.2% completed the survey from the U.S., 12.5% from the U.K., 9.1% from Canada, 5.6% from India, 3.8% from South Africa. Motivations were to determine need to consult a physician (44.2%), to secure medical advice without visiting a physician (21.0%), and to confirm a diagnosis received (14.2%). Forty-three percent were first time users of virtual triage, 36.6% utilized a triage engine at least once every few months or more often. Pre-triage, 40.5% did not know what level of healthcare they were planning to utilize, 33.9% stated they intended to seek a physician consultation, 23.7% engage self-care and 1.8% seek emergency care. Virtual triage recommended 56.8% of patient-users consult a physician, 33.8% seek emergency care and 9.4% engage self-care. In three-fourths, virtual triage helped users decide level of care to pursue. Among 74.1%, triage recommended care different than pre-triage intentions. Post-triage, those who remained uncertain of their care path decreased by 25.4%. Patient-user experience and satisfaction with virtual triage was high, with 80.1% stating that they were highly likely or likely to use it again, and interest in and willingness to use telemedicine doubled.

Conclusion

Virtual triage successfully redirected patient-users who initially planned to seek an inappropriate level of care acuity, reduced patient uncertainty of care path, and doubled the percentage of patients amenable to telemedicine and virtual health engagement. Patient-users were highly satisfied with virtual triage and the virtual triage patient experience, and a large majority will use virtual triage recurrently in the future.
PM2.5 induce lifespan reduction, insulin/IGF-1 signaling pathway disruption and lipid metabolism disorder in Caenorhabditis elegans
Authors: Zhang Wenjing , Li Zinan , Li Guojun , Kong Ling , Jing Haiming , Zhang Nan , Ning Junyu , Gao Shan , Zhang Yong , Wang Xinyu , Tao Jing
Published: February 2023

Introduction

Exposure to fine particulate matter (PM), especially PM2.5, can induce various adverse health effects in populations, including diseases and premature death, but the mechanism of its toxicity is largely unknown.

Methods

Water-soluble components of PM2.5 (WS-PM2.5) were collected in the north of China in winter, and combined in two groups with the final concentrations of 94 μg/mL (CL group, AQI ≤ 100) and 119 μg/mL (CH group, 100 < AQI ≤ 200), respectively. The acute and long-term toxic effects of WS-PM2.5 samples were evaluated in several aspects such as development, lifespan, healthspan (locomotion behavior, heat stress tolerance, lipofucin). DAF mutants and genes were applied to verify the action of IIS pathway in WS-PM2.5 induced-effects. RNA-Sequencing was performed to elucidate the molecular mechanisms, as well as ROS production and Oil red O staining were also served as means of mechanism exploration.

Results

Body length and lifespan were shortened by exposure to WS-PM2.5. Healthspan of nematodes revealed adverse effects evaluated by head thrash, body bend, pharyngeal pump, as well as intestinal lipofuscin accumulation and survival time under heat stress. The abbreviated lifespan of daf-2(e1370) strain and reduced expression level of daf-16 and hsp-16.2 indicated that IIS pathway might be involved in the mechanism. Thirty-five abnormally expressed genes screened out by RNA-Sequencing techniques, were functionally enriched in lipid/lipid metabolism and transport, and may contribute substantially to the regulation of PM2.5 induced adverse effects in nematodes.

Conclusion

WS-PM2.5 exposure induce varying degrees of toxic effects, such as body development, shorten lifespan and healthspan. The IIS pathway and lipid metabolism/transport were disturbed by WS-PM2.5 during WS-PM2.5 exposure, suggesting their regulatory role in lifespan determination.
Green space justice amid COVID-19: Unequal access to public green space across American neighborhoods
Authors: Gao Shuqi , Zhai Wei , Fu Xinyu
Published: February 2023

Countries around the world have resorted to issuing stay-at-home orders to slow viral transmission since the COVID-19 pandemic. During the lockdown, access to public park plays a central role in the public health of surrounding communities. However, we know little about how such an unprecedented policy may exacerbate the preexisting unequal access to green space (i.e., green space justice). To address this research void, we used difference-in-difference models to examine socioeconomic disparities, urban-rural disparities, and mobility disparities in terms of public park access in the United States. Our national analysis using the weekly mobile phone movement data robustly suggests the following three key findings during COVID-19: (1) The elderly, non-college-educated people, poor people, and blacks are less likely to visit public parks frequently, while unemployed people appear to be the opposite. (2) Compared to rural areas, populations in urban neighborhoods appear to visit public parks more frequently and they generally go to larger parks to minimize the risk of infection. (3) Populations in neighborhoods with higher private vehicle ownership or those with a higher density of transit stops would more frequently visit and travel a longer distance to public parks during the stay-at-home order. Our results imply that conventional inequality in green space access may still exist and even become worse during COVID-19, which could negatively impact people's health during isolation. We suggest that special attention should be paid to park-poor neighborhoods during the pandemic and in the post-pandemic recovery phase.
Associations between life-course household wealth mobility and adolescent physical growth, cognitive development and emotional and behavioral problems: A birth cohort in rural western China
Authors: Tian Jiaxin , Zhu Yingze , Liu Shuang , Wang Liang , Qi Qi , Deng Qiwei , Andegiorgish Amanuel Kidane , Elhoumed Mohamed , Cheng Yue , Shen Chi , Zeng Lingxia , Zhu Zhonghai
Published: February 2023

Background

Parental household wealth has been shown to be associated with offspring health conditions, while inconsistent associations were reported among generally healthy population especially in low- and middle- income countries (LMICs). Whether the household wealth upward mobility in LMICs would confer benefits to child health remains unknown.

Methods

We conducted a prospective birth cohort of children born to mothers who participated in a randomized trial of antenatal micronutrient supplementation in rural western China. Household wealth were repeatedly assessed at pregnancy, mid-childhood and early adolescence using principal component analysis for household assets and dwelling characteristics. We used conditional gains and group-based trajectory modeling to assess the quantitative changes between two single-time points and relative mobility of household wealth over life-course, respectively. We performed generalized linear regressions to examine the associations of household wealth mobility indicators with adolescent height- (HAZ) and body mass index-for-age and sex z score (BAZ), scores of full-scale intelligent quotient (FSIQ) and emotional and behavioral problems.

Results

A total of 1,188 adolescents were followed, among them 59.9% were male with a mean (SD) age of 11.7 (0.9) years old. Per SD conditional increase of household wealth z score from pregnancy to mid-childhood was associated with 0.11 (95% CI 0.04, 0.17) SD higher HAZ and 1.41 (95% CI 0.68, 2.13) points higher FSIQ at early adolescence. Adolescents from the household wealth Upward trajectory had a 0.25 (95% CI 0.03, 0.47) SD higher HAZ and 4.98 (95% CI 2.59, 7.38) points higher FSIQ than those in the Consistently low subgroup.

Conclusion

Household wealth upward mobility particularly during early life has benefits on adolescent HAZ and cognitive development, which argues for government policies to implement social welfare programs to mitigate or reduce the consequences of early-life deprivations. Given the importance of household wealth in child health, it is recommended that socioeconomic circumstances should be routinely documented in the healthcare record in LMICs.
Community Engagement Alliance (CEAL) Against COVID-19 Disparities: Academic-community partnership to support workforce capacity building among Arizona community health workers
Authors: Jiménez Dulce J. , Gomez Omar , Meraz Ruby , Pollitt Amanda M. , Evans Linnea , Lee Naomi , Ignacio Matt , Garcia Katherine , Redondo Richard , Redondo Floribella , Williamson Heather J. , Oesterle Sabrina , Parthasarathy Sairam , Sabo Samantha
Published: February 2023

The COVID-19 pandemic has both highlighted and worsened existing health inequities among communities of color and structurally vulnerable populations. Community Health Workers, inclusive of Community Health Representatives (CHW/Rs) have entered the spotlight as essential to COVID-19 prevention and control. To learn about community experiences and perspectives related to COVID-19 and inform CHW/R workforce capacity building efforts, a series of focus groups were conducted with CHW/Rs throughout Arizona at two time points in 2021. Throughout the data collection and analysis process, researchers and community partners engaged in ongoing and open dialogue about what CHW/Rs on the ground were reporting as priority community concerns, needs, and challenges. Thus, CHW/Rs informed the development of culturally and linguistically relevant health education messages, materials, and training for CHW/Rs. In this community case study, we detail the efforts of partnership between a statewide CHW professional association and an academic research team that facilitated rapid decision-making and knowledge sharing to create community-grounded tools and resources supportive of CHW/R workforce capacity building in the context of the COVID-19 pandemic.
Nutrition in City Ecosystems (NICE): Protocol of a multi-sectoral development project to improve food and nutrition security of secondary city populations in Bangladesh, Kenya and Rwanda
Authors: Speich Cornelia , Barth-Jaeggi Tanja , Musard Capucine , Havugimana Cassien , Nwokoro Charles , Gakuba Elvis , Zamil Farhad , Sécula Florence , Thönnissen Carmen , Six Johan , Kraemer Klaus , van Zutphen Kesso Gabrielle , Sonnevelt Martijn , Tshering Puja P. , Erismann Séverine , van den Berg Sophie , Winter Simon , Johnson-Chadwick Victoria , Pannatier Marnie , Gavin-Smith Breda , Barjolle Dominique , Prytherch Helen
Published: February 2023

Background

Secondary cities tend to be better linked with local food systems than primate cities, acting as important platforms to trade agricultural produce with rural surrounding. COVID-19, conflicts and climate change continue to expose inefficiencies in food systems and have further exacerbated malnutrition, calling for substantial food systems transformations. However, tackling current food systems' challenges requires new approaches to ensure food and nutrition security. Nutritious and agroecologically produced food offer the potential to transform food systems by improving diets and alleviating pressure on the environment, as well as by creating jobs and reducing poverty. This paper describes the design of a project by a Swiss public-private consortium to improve food and nutrition security and to reduce poverty in city ecosystems in six secondary cities in Bangladesh, Kenya and Rwanda through governance/policy and supply and demand side interventions.

Methods

The Nutrition in City Ecosystems (NICE) project promotes well-balanced nutrition for city populations through interdisciplinary agricultural, food, and health sector collaborations along city-specific value chains. Adopting a transdiciplinary systems approach, the main interventions of NICE are (i) advocacy and policy dialogue, (ii) building of decentralized institutional capacity in multi-sectoral collaborations, (iii) support of data-driven planning, coordination and resource mobilization, (iv) anchoring of innovations and new approaches in city-level partnerships, (v) capacity building in the agricultural, retail, health and education sectors, as well as (vi) evidence generation from putting policies into practice at the local level. NICE is coordinated by in-country partners and local offices of the Swiss public-private consortium partners.

Discussion

The NICE project seeks to contribute to urban food system resilience and enhanced sustainable nutrition for city populations by (A) strengthening urban governance structures involving key stakeholders including women and youth, (B) generating income for producers along the supply chain, (C) triggering change in producers' and consumers' behavior such that nutritious and agroecologically produced foods are both in demand as well as available and affordable in urban markets, and (D) allowing a scale up of successful approaches to other national and international cities and city networks.
Safety and immunogenicity of the third (booster) dose of inactivated and recombinant protein SARS-CoV-2 vaccine for patients with endocrine-related cancer
Authors: Han Shanshan , Yang Yuping , Wang Tingrui , Song Rui , Hu Daixing , Peng Mingli , Lin Zijing , Deng Qin , Ren Hong , Ming Jia
Published: February 2023

Background

Our study aimed to evaluate the safety and immunogenicity of the third (booster) dose of the COVID-19 vaccine for patients with endocrine-related cancers.

Methods

This observational study involved 94 breast cancer patients, 92 thyroid cancer patients, and 123 healthy individuals who had received the third (booster) dose of the COVID-19 vaccine. Data on the adverse effects, serum anti-receptor binding domain (RBD)-immunoglobulin (Ig) G, and neutralizing antibodies (NAbs) were collected prospectively.

Results

The serum anti-RBD-IgG and NAb titers were significantly lower for the patients with endocrine-related malignancies than for the healthy controls (3.01 [IQR: 1.11–6.70] vs. 4.19 [1.95–9.11], p = 0.001; 0.23 [0.11–0.52] vs. 0.41 [0.22–0.78], p = 0.001), and the seroconversion rates of anti-RBD-IgG and NAbs showed similar results. The serum antibody titers and seroconversion rates were significantly lower for patients aged ≥65 years with endocrine-related cancers, but there were no significant differences related to gender, vaccine type, or cancer type. Subgroup analysis showed that the antibody titers and seroconversion rates were significantly lower for patients with intermediate to advanced breast cancer, HR–/Her2+ breast cancer, and breast cancer undergoing treatment than for healthy controls. In contrast, breast cancer patients who completed their treatment and those who received endocrine therapy after completing their treatment were not significantly different from healthy controls. The NAbs titers and seroconversion rates were significantly lower for patients with primary thyroid cancer (0.19 [IQR: 0.10–0.46] vs. 0.41 [0.22–0.78], p = 0.003; 55.9 vs. 84.9%, p < 0.001); the seroconversion rates were significantly higher for the patients with combined Hashimoto's thyroiditis than for those without it. Multiple linear regression showed that patients aged ≥65 years who were receiving treatment were at risk of having lower antibody levels.

Conclusion

The third (booster) dose of the COVID-19 vaccine is safe and well-tolerated. Our data support a third (booster) dose of the SARS-CoV-2 vaccine for breast and thyroid cancer patients. Breast cancer patients aged ≥65 years who are receiving treatment should be more protected, while thyroid cancer and breast cancer patients who have completed their treatment can be vaccinated like the general population.
Sex and gender aspects in diabetes mellitus: Focus on access to health care and cardiovascular outcomes
Authors: Gisinger Teresa , Azizi Zahra , Alipour Pouria , Harreiter Jürgen , Raparelli Valeria , Kublickiene Karolina , Herrero Maria Trinidad , Norris Colleen M. , El Emam Khaled , Pilote Louise , Kautzky-Willer Alexandra
Published: February 2023

Aims

The aim of this study was to elucidate whether sex and gender factors influence access to health care and/or are associated with cardiovascular (CV) outcomes of individuals with diabetes mellitus (DM) across different countries.

Methods

Using data from the Canadian Community Health Survey (8.4% of respondent reporting DM) and the European Health Interview Survey (7.3% of respondents reporting DM), were analyzed. Self-reported sex and a composite measure of socio-cultural gender was constructed (range: 0–1; higher score represent participants who reported more characteristics traditionally ascribed to women). For the purposes of analyses the Gender Inequality Index (GII) was used as a country level measure of institutionalized gender.

Results

Canadian females with DM were more likely to undergo HbA1c monitoring compared to males (OR = 1.26, 95% CI: 1.01–1.58), while conversely in the European cohort females with DM were less likely to have their blood sugar measured compared to males (OR = 0.88, 95% CI: 0.79–0.99). A higher gender score in both cohorts was associated with less frequent diabetes monitoring. Additionally, independent of sex, higher gender scores were associated with higher prevalence of self-reported heart disease, stroke, and hospitalization in all countries albeit European countries with medium-high GII, conferred a higher risk of all outcomes and hospitalization rates than low GII countries.

Conclusion

Regardless of sex, individuals with DM who reported characteristics typically ascribed to women and those living in countries with greater gender inequity for women exhibited poorer diabetes care and greater risk of CV outcomes and hospitalizations.
MRI brain tumor segmentation using residual Spatial Pyramid Pooling-powered 3D U-Net
Authors: Vijay Sanchit , Guhan Thejineaswar , Srinivasan Kathiravan , Vincent P. M. Durai Raj , Chang Chuan-Yu
Published: February 2023

Brain tumor diagnosis has been a lengthy process, and automation of a process such as brain tumor segmentation speeds up the timeline. U-Nets have been a commonly used solution for semantic segmentation, and it uses a downsampling-upsampling approach to segment tumors. U-Nets rely on residual connections to pass information during upsampling; however, an upsampling block only receives information from one downsampling block. This restricts the context and scope of an upsampling block. In this paper, we propose SPP-U-Net where the residual connections are replaced with a combination of Spatial Pyramid Pooling (SPP) and Attention blocks. Here, SPP provides information from various downsampling blocks, which will increase the scope of reconstruction while attention provides the necessary context by incorporating local characteristics with their corresponding global dependencies. Existing literature uses heavy approaches such as the usage of nested and dense skip connections and transformers. These approaches increase the training parameters within the model which therefore increase the training time and complexity of the model. The proposed approach on the other hand attains comparable results to existing literature without changing the number of trainable parameters over larger dimensions such as 160 × 192 × 192. All in all, the proposed model scores an average dice score of 0.883 and a Hausdorff distance of 7.84 on Brats 2021 cross validation.
Efficacy of a comprehensive strategy for the detection and treatment of hepatitis C infection in a population attending addiction centers
Authors: Corona-Mata Diana , Rivero-Juárez Antonio , Camacho Ángela , Ruiz-Torres Laura , Ruiz-Cáceres Inmaculada , de la Fuente Darder Bartolomé , Cáceres-Anillo David , de Guía Castro-Granados María , Lizaur-Barbudo María , Victoria Cabrera-Gisbert María , Redondo-Écija Justa , Aparicio-Aparicio Ana , Manchado-López Leticia , Cobos Luciano , Pérez-Valero Ignacio , Rivero Antonio
Published: February 2023

Background and aims

The burden hepatitis C infection in people with history or current drug use suppose a high risk of hepatic complications and transmission infectious disease. This population is poor linked to heath system and is difficult to achieve them and support treatment because they have high rates of lost follow-up. Our aim was to evaluate an intervention for the diagnosis and treatment of chronic hepatitis C and HIV in this population.

Methods

Six-hundred and eighty-three people attended in Drugs and Addictions Centers (DAC) were asked to participate in health counseling and provide blood sample for test HCV, HIV, and syphilis from April 2019 to June 2020. Totally 556 subjects were surveyed and tested. All of them were assigned to a patient navigation program to improve health education and linking to the sanitary system. Hepatitis C infection patients were evaluated in an ampliated medical consult to evaluate hepatic stage with transient liver elastography and initiated Direct Acting Antivirals to achieve Sustained Viral Response.

Results

Of the 556 patients who agreed to participate in the study, 33 (5.9%) had active HCV infection. Of the 33 patients infected with HCV, three were lost to follow-up once the diagnosis of HCV infection was made. Twenty-eight patients (93.3%) completed treatment and 26 achieved Sustained Viral Response (78.8%). Of the 30 patients, seven (23.3%) had advanced fibrosis, and of these, four (16.6%) had liver cirrhosis. One of the cirrhotic patients had hepatic space-occupying lesions at the baseline evaluation and was diagnosed with hepatocarcinoma.

Conclusions

Our study suggests that the implementation of strategies based on personalized intervention models can contribute to the control of HCV infection in DAC users.
In-service training policy during the COVID-19 pandemic: The case of the agents of the farmers, rural people, and nomads social insurance fund
Authors: Ghadermarzi Hamed , Ataei Pouria , Mottaghi Dastenaei Afshin , Bassullu Caglar
Published: February 2023

Introduction

The COVID-19 pandemic has posed the in-service training of agents of the Farmers, Rural People, Nomads Social Insurance Fund (hereafter the Fund) to many problems. In-service training is one of the most effective development factors for organizational goals. This sort of training will increase employees' skills and subsequently improve their job performance. Accordingly, the present research mainly aimed to shed light on the effect of in-service training policy on employees' capabilities and job performance.

Methods

The research was conducted among the agents of the Fund in Fars province, Iran (N = 197) out of whom 127 agents were sampled by simple randomization. The research instrument was a standard questionnaire whose face and content validity was confirmed by a panel of experts and its reliability was determined by calculating Cronbach's alpha in a pilot study. The results showed that the indicators used to measure the research variables were acceptably consistent with the factor structure and the theoretical framework of the research.

Results and discussion

Based on the findings, in-service training in the Fund during the COVID-19 pandemic has had a positive and significant effect on the agents' capabilities (communication and team-working skills, creativity and problem-solving skills, commitment and responsibility, technical information and knowledge, and technical and practical skills) and job performance at the individual, technical, and general levels. Also, the agents' capabilities have had a positive and significant influence on their job performance. It can be concluded that in-service training can influence the agents' capabilities and job performance and improve organizational performance during the COVID-19 pandemic. Thus, the enhancement of in-service training courses' quantity and quality during the COVID-19 pandemic can influence the job performance of the agents at the individual, general, and technical performance levels.
Characteristics analysis of 157 cases of central airway stenosis due to tracheobronchial tuberculosis: A descriptive study
Authors: Zhuang Rongjuan , Yang Mingjin , Xu Li , Li Yishi , Li Ying , Hu Tingting , Chen Yan , Nie Xiao , Yan Xiaofeng , Kong Xianghua , Yang Song , Guo Shuliang
Published: February 2023

Background

Tracheobronchial stenosis, particularly central airway stenosis, which frequently results in severe complications such as lung damage, occurs in patients with tracheobronchial tuberculosis (TBTB).

Objectives

To analyze the clinical characteristics of patients with central airway stenosis due to tuberculosis (CASTB).

Methods

Retrospective analysis was performed on the clinical features, radiological features, bronchoscopic features and treatment of 157 patients who were diagnosed with CASTB in two tertiary hospitals in Chongqing, China, from May 2020 to May 2022.

Results

CASTB mostly occurs in young patients and females. Patients with CASTB exhibited different symptoms repeatedly during the disease, especially varying degrees of dyspnea, prompting many patients to undergo bronchoscopic intervention and even surgery. Patients with cicatricial strictures constituted the highest proportion of the TBTB subtype with CASTB and 35.7% of the patients with CASTB were found to have tracheobronchomalacia (TBM) under bronchoscopy. CASTB and TBM mainly involved the left main bronchus. Patients with lower levels of education had higher rates of TBM. Patients with TBM manifested shortness of breath more frequently than patients without TBM. Patients with TBTB who had undergone bronchoscopic interventions have a higher rate of TBM.

Conclusions

Despite mostly adequate anti-tuberculosis chemotherapy, patients with TBTB can present with CASTB involving severe scarring stenosis, bronchial occlusion, tracheobronchomalacia and even destroyed lung.