bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of remimazolam tosilate on the incidence of hypoxemia in elderly patients undergoing gastrointestinal endoscopy: A bi-center, prospective, randomized controlled study
Authors: Liu Fang , Cheng Xiaoyan , Wang Yingjie , Li Kai , Peng Tianliang , Fang Ningning , Pasunooti Kalyan K. , Jun Seungho , Yang Xiaomei , Wu Jianbo
Published: April 2023

Background: Remimazolam tosilate is a new ultra-short-acting benzodiazepine sedative medicine. In this study, we evaluated the effect of remimazolam tosilate on the incidence of hypoxemia during sedation in elderly patients undergoing gastrointestinal endoscopy.

Methods: Patients in the remimazolam group received an initial dose of 0.1 mg/kg and a bolus dose of 2.5 mg of remimazolam tosilate, whereas patients in the propofol group received an initial dose of 1.5 mg/kg and a bolus dose of 0.5 mg/kg of propofol. Patients received ASA standard monitoring (heart-rate, non-invasive blood pressure, and pulse oxygen saturation) during the entire examination process. The primary outcome was the incidence of moderate hypoxemia (defined as 85%≤ SpO2< 90%, >15s) during the gastrointestinal endoscopy. The secondary outcomes included the incidence of mild hypoxemia (defined as SpO2 90%–94%) and severe hypoxemia (defined as SpO2< 85%, >15s), the lowest pulse oxygen saturation, airway maneuvers used to correct hypoxemia, patient’s hemodynamic as well as other adverse events.

Results: 107 elderly patients (67.6 ± 5.7 years old) in the remimazolam group and 109 elderly patients (67.5 ± 4.9 years old) in the propofol group were analyzed. The incidence of moderate hypoxemia was 2.8% in the remimazolam group and 17.4% in the propofol group (relative risk [RR] = 0.161; 95% confidence interval [CI], 0.049 to 0.528; p < 0.001). The frequency of mild hypoxemia was less in the remimazolam group, but not statistically significant (9.3% vs. 14.7%; RR = 0.637; 95% CI, 0.303 to 1.339; p = 0.228). There was no significant difference in the incidence of severe hypoxemia between the two groups (4.7% vs. 5.5%; RR = 0.849; 95% CI, 0.267 to 2.698; p = 0.781). The median lowest SpO2 during the examination was 98% (IQR, 96.0%–99.0%) in patients in the remimazolam group, which was significantly higher than in patients in the propofol group (96%, IQR, 92.0%–99.0%, p < 0.001). Patients in the remimazolam group received more drug supplementation during endoscopy than patients in the propofol group (p = 0.014). There was a statistically significant difference in the incidence of hypotension between the two groups (2.8% vs. 12.8%; RR = 0.218; 95% CI, 0.065 to 0.738; p = 0.006). No significant differences were found in the incidence of adverse events such as nausea and vomiting, dizziness, and prolonged sedation.

Conclusion: This study explored the safety of remimazolam compared with propofol during gastrointestinal endoscopy in elderly patients. Despite the increased supplemental doses during sedation, remimazolam improved risk of moderate hypoxemia (i.e., 85%≤ SpO2 < 90%) and hypotension in elderly patients.
Berberine stimulates lysosomal AMPK independent of PEN2 and maintains cellular AMPK activity through inhibiting the dephosphorylation regulator UHRF1
Authors: Ren Gang , Ding Yu-Wei , Wang Lu-Lu , Jiang Jian-Dong
Published: April 2023

Aim: AMPK is the key regulatory kinase mediating the effect of berberine (BBR) and metformin on metabolic improvement. The present study investigated the mechanism of BBR on AMPK activation at low doses, which was different from that of metformin.

Methods: Lysosomes were isolated, and AMPK activity assay was performed. PEN2, AXIN1 and UHRF1 were investigated through gain/loss of function approaches, including overexpression, RNA interfering and CRISPR/Cas9-mediated gene knockout. Immunoprecipitation was utilized for detecting the interaction of UHRF1 and AMPKα1 after BBR treatment.

Results: BBR activated lysosomal AMPK, but weaker than metformin. AXIN1 mediated BBR’s effect on lysosomal AMPK activation, while PEN2 did not. BBR, but not metformin, decreased UHRF1 expression by promoting its degradation. BBR reduced the interaction between UHRF1 and AMPKα1. And overexpression of UHRF1 abolished the effect of BBR on AMPK activation.

Conclusion: BBR activated lysosomal AMPK as dependent on AXIN1, but not PEN2. BBR maintained cellular AMPK activity by reducing UHRF1 expression and its interaction with AMPKα1. The mode of action of BBR was different from that of metformin on AMPK activation.
Pericyte-derived cells participate in optic nerve scar formation
Authors: Preishuber-Pflügl Julia , Mayr Daniela , Altinger Veronika , Brunner Susanne M. , Koller Andreas , Runge Christian , Ladek Anja-Maria , Lenzhofer Markus , Rivera Francisco J. , Tempfer Herbert , Aigner Ludwig , Reitsamer Herbert A. , Trost Andrea
Published: April 2023

Introduction: Pericytes (PCs) are specialized cells located abluminal of endothelial cells on capillaries, fulfilling numerous important functions. Their potential involvement in wound healing and scar formation is achieving increasing attention since years. Thus, many studies investigated the participation of PCs following brain and spinal cord (SC) injury, however, lacking in-depth analysis of lesioned optic nerve (ON) tissue. Further, due to the lack of a unique PC marker and uniform definition of PCs, contradicting results are published.

Methods: In the present study the inducible PDGFRβ-P2A-CreERT2-tdTomato lineage tracing reporter mouse was used to investigate the participation and trans-differentiation of endogenous PC-derived cells in an ON crush (ONC) injury model, analyzing five different post lesion time points up to 8 weeks post lesion.

Results: PC-specific labeling of the reporter was evaluated and confirmed in the unlesioned ON of the reporter mouse. After ONC, we detected PC-derived tdTomato+ cells in the lesion, whereof the majority is not associated with vascular structures. The number of PC-derived tdTomato+ cells within the lesion increased over time, accounting for 60–90% of all PDGFRβ+ cells in the lesion. The presence of PDGFRβ+tdTomato- cells in the ON scar suggests the existence of fibrotic cell subpopulations of different origins.

Discussion: Our results clearly demonstrate the presence of non-vascular associated tdTomato+ cells in the lesion core, indicating the participation of PC-derived cells in fibrotic scar formation following ONC. Thus, these PC-derived cells represent promising target cells for therapeutic treatment strategies to modulate fibrotic scar formation to improve axonal regeneration.
Multigene phylogeny reveals a cryptic diversity in the genus Dinobryon (Chrysophyceae) with integrative description of five new species
Authors: Jeong Minseok , Wang Yitong , Kim Jong Im , Shin Woongghi
Published: April 2023

Introduction

The genus Dinobryon is one of the most recognizable chrysophyte genera, characterized by dendroid colonies with a biflagellate inside each cellulosic lorica. The representative forms of lorica are cylindrical, conical, vase, or funnel shaped, with undulation on the lorica wall. Traditionally, the morphological characteristics of the lorica and the colony organization have been used for the delimitation of Dinobryon species.

Methods

To understand the taxonomy and phylogeny of colonial Dinobryon species, we performed molecular and morphological studies using 39 unialgal cultures and 46 single colony isolations from environmental specimens collected in Korea. We used a nuclear internal transcript spacer (ITS1-5.8S-ITS2) to find the genetic diversity of Dinobryon from environmental samples and a combined dataset from six gene sequences (nuclear SSU and LSU rRNA, plastid LSU rRNA, rbcL and psaA, and mitochondrial CO1 genes) for phylogenetic analysis.

Results and discussion

We found 15 different lineages based on the genetic diversity of the nuclear ITS sequences. The phylogenetic tree of the colonial species based on the combined multigene dataset were divided into 18 subclades, including five new species, each with unique molecular signatures for the E23-5 helix of the V4 region in the nuclear SSU rRNA and the E11-1 helix of D7b, and the E20-1 helix of D8 regions in the nuclear LSU rRNA. Morphological studies were focused on lorica dimension and shape, and stomatocyst morphology. The Dinobryon species showed similarities or differences in lorica morphologies between and within species, and also differences in lorica size between culture and environmental samples. Five Dinobryon species formed distinctive stomatocysts, their stomatocyst morphologies, including collar structure, surface ornamentation, and cyst shape, showed unique characteristics in each species and were useful for identification. Here, we propose five new species based on morphological and molecular evidences: D. cylindricollarium, D. exstoundulatum, D. inclinatum, D. similis, and D. spinum.
Assessing the Best Supplier Selection Criteria in Supply Chain Management During the COVID-19 Pandemic
Authors: Hou Yumei , Khokhar Maryam , Zia Sayma , Sharma Anshuman
Published: April 2023

In the last 10 years, organizations and researchers have recognized the importance of sustainable supply chain management (SSCM) because of the consumers, -profit and non-profit organizations, laws and regulations, and consumer social and corporate responsibilities. Supplier selection, environmental effects such as social cooperation, and other SSCM programmes, can all help to achieve the “triple bottom line (TBL)” of economic, environmental, and social advantages. Sustainable supplier selection (SSS) and firm performance are important factors in supply chain management (SCM). Organizations will traditionally consider a new framework when evaluating SSS performance to obtain all-encompassing criteria/sub-criteria of the sustainability index by encapsulating sustainability. This paper compiles 12 subcriteria for three sustainability pillars, namely economic, environmental, and social performance. Despite the fact that many articles on SSS and evaluation were published during COVID-19, there seems to be little research on sustainability issues to date. The goal of this study is to suggest a fuzzy multicriteria approach to SSCM planning. Additionally, using the TBL method, the problem of determining a current model for SSS in the supply chain was investigated. The linguistic value of the subjective preference of experts is represented by triangular fuzzy numbers. Fuzzy TOPSIS (technique for order preference by similarity to ideal solution) is proposed to use standard weights to rank SSS for qualitative performance evaluation. COVID-19, on the other hand, has a detrimental impact on SSS and company results. The organization’s performance suffers as a result of the COVID-19 shutdown. The proposed method is demonstrated using an example.
Work-related coping behaviour and experience patterns in university students: a review of 20  years of research
Authors: Mašková Ivana
Published: April 2023

Work-related coping behaviour and experience patterns (WCEP) is the conceptualisation of personal experience with occupational stress and of the typical behavioural responses for coping with such stress. The objective of this review, which is based on 69 references that used the WCEP inventory in university students, is to offer a comprehensive overview of the findings on WCEP and their correlates in the student population. The results of the published studies consistently show that female students, teacher education students (compared to medical students) and students who receive insufficient social and financial support are at greater risk for being assigned to work-related patterns that indicate vulnerability to burnout and occupational health issues. Moreover, students assigned to these patterns, especially to the resigned (burnout) pattern, are prone to manifest other negative characteristics, such as less adaptive personality traits and coping strategies, vulnerability to stress, lower quality motivation, lack of commitment to the chosen career and suitability for the profession, and impaired physical and mental health. In contrast, the most desirable correlates, such as adaptive personality traits, higher quality motivation, commitment to the chosen career, suitability for the profession, stress resistance, adaptive coping and better physical and mental health, were related to the healthy ambitious pattern. Nevertheless, further research is needed to analyse work-related coping behaviour and experience patterns beyond the German speaking population to increase the generalisability of the findings.
Videoconferencing analytic psychodrama in treating young adults’ psychological suffering: preliminary results
Authors: Biolcati Roberta , Ambrosini Federica , Albani Alessandra , Di Stefano Giovanni
Published: April 2023

The study aims to explore the effects that videoconferencing Analytic Psychodrama (AP) has on the psychological wellbeing and emotional competence of young adults who are suffering from mental health problems. Twenty-two undergraduate students, asking for help at the Psychological Counselling Service of the University of Bologna for anxiety-depressive problems, took part in the three online groups that met weekly from October 2020 to July 2021. The Clinical Outcomes in Routine Evaluation Outcome Measure, the Trait Emotional Intelligence Questionnaire Short Form, the Toronto Alexithymia Scale, the Interpersonal Reactivity Index, and the Group Climate Questionnaire were used as test–retest questionnaires for clinical outcomes, emotional competence, and group climate evaluations. There was a statistically significant difference between the pre-test and 10-month scores for patients in clinical outcomes. Alexithymia significantly decreased and emotional intelligence and group engagement increased post-intervention. Videoconferencing AP sounds promising for alleviating psychological problems and to improve young adults’ emotional competence.
The need for ecological momentary assessment in researching emotional factors in language education
Authors: Li Xiaodong
Published: April 2023

Language learning is an emotional and dynamic process, which is marked by fluctuations in language learners’ positive and negative emotional variables (e.g., boredom, enjoyment, anxiety). Presumably, evidence can be found for an ecological view of the patterns and variations involved in language learners’ emotions under the influence of the interactive individual and contextual elements of classroom learning. The present study contends that an ecological momentary assessment (EMA), which is compatible with the complex dynamic system theory (CDST) can help to explore the dynamics of language learners’ emotional variables as they develop out of the process of classroom language learning. EMA is capable of tracing the moment-by-moment changes in a certain emotional trait in language learners as they are learning a foreign or second language. This innovative approach to research compensates for the shortcomings of retrospective studies (the delay of recalls) and also single-shot research designs (for data collection). It is fit for the assessment of the emergent patterns of L2 emotional variables. The distinctive features and pedagogical implications will be further discussed here.
Psychological distress among Afghan refugees in Norway as a function of their integration
Authors: Brea Larios Dixie , Sam David L. , Sandal Gro Mjeldheim
Published: April 2023

Background

Often, refugees are susceptible to mental health problems due to adversities experienced before, during, and after the flight. Through a cross-sectional study, the present study examines the relationship between different aspects of integration and psychological distress among Afghans living in Norway.

Methods

The participants were recruited through e-mail invitations, refugee-related organizations, and social media platforms. The participants (N = 114) answered questions about integration across multiple dimensions (psychological, social, navigational, economic, and linguistic) in line with the Immigration Policy Lab index (IPL -12/24). Hopkins symptoms checklist (HSCL-25) was used to assess psychological distress.

Results

Based on hierarchical multiple regression analysis, both the psychological dimension (0.269 p < 0.01) and the navigational dimension (0.358 p < 0.05) of integration predicted psychological distress.

Discussion/Conclusion

The results suggest that the psychological aspects of integration, such as being part of a community, having feelings of security, and a sense of belonging, are beneficial for the mental health and well-being of the Afghans in Norway and contribute further to other aspects of integration.
School-based mental health screenings with Ukrainian adolescent refugees in Germany: Results from a pilot study
Authors: Catani Claudia , Wittmann Jasmin , Schmidt Telja Lucia , Wilker Sarah , Neldner Sina , Neuner Frank
Published: April 2023

Since the Russian invasion of Ukraine in February 2022, high numbers of Ukrainians, mostly women and children, have left the country. As of today, Germany has accepted more than one million refugees fleeing from Ukraine including ~200,000 children and adolescents registered in German schools. Since refugee minors are typically affected by high rates of mental health issues, the identification of potential psychological problems at an early stage after arrival is essential in order to make timely referrals for vulnerable youth to diagnostic or treatment services possible. The aim of the present study was to test the feasibility of a classroom-based mental health screening procedure and to assess symptoms of PTSD, depression, and anxiety in a small sample of adolescents who had fled to Germany. Forty-two adolescents (n = 20 girls) took part in the study. Screening results showed that more than half of the sample had elevated ratings in the Refugee Health Screener (RHS) and about 45% reported clinically significant levels of PTSD. Overall, the amount of both mental health problems and current worries related to the war was significantly higher in girls compared to boys. In general, screenings were well received by the adolescents. The findings of this pilot study point to a considerable level of mental health problems and distress in adolescent refugees affected by the recent war in Ukraine. Brief psychological screenings within the school setting might represent a promising approach to identifying potential mental health disorders as early as possible in newly arriving refugee youth.
Associations between prefrontal PI (16:0/20:4) lipid, TNC mRNA, and APOA1 protein in schizophrenia: A trans-omics analysis in post-mortem brain
Authors: Sano Fumito , Kikushima Kenji , Benner Seico , Xu Lili , Kahyo Tomoaki , Yamasue Hidenori , Setou Mitsutoshi
Published: April 2023

Background

Though various mechanisms have been proposed for the pathophysiology of schizophrenia, the full extent of these mechanisms remains unclear, and little is known about the relationships among them. We carried out trans-omics analyses by comparing the results of the previously reported lipidomics, transcriptomics, and proteomics analyses; all of these studies used common post-mortem brain samples.

Methods

We collected the data from three aforementioned omics studies on 6 common post-mortem samples (3 schizophrenia patients and 3 controls), and analyzed them as a whole group sample. Three correlation analyses were performed for each of the two of three omics studies in these samples. In order to discuss the strength of the correlations in a limited sample size, the p-values of each correlation coefficient were confirmed using the Student’s t-test. In addition, partial correlation analysis was also performed for some correlations, to verify the strength of the impact of each factor on the correlations.

Results

The following three factors were strongly correlated with each other: the lipid level of phosphatidylinositol (PI) (16:0/20:4), the amount of TNC mRNA, and the quantitative signal intensity of APOA1 protein. PI (16:0/20:4) and TNC showed a positive correlation, while PI (16:0/20:4) and APOA1, and TNC and APOA1 showed negative correlations. All of these correlations reached at p < 0.01. PI (16:0/20:4) and TNC were decreased in the prefrontal cortex of schizophrenia samples, while APOA1 was increased. Partial correlation analyses among them suggested that PI (16:0/20:4) and TNC have no direct correlation, but their relationships are mediated by APOA1.

Conclusion

The current results suggest that these three factors may provide new clues to elucidate the relationships among the candidate mechanisms of schizophrenia, and support the potential of trans-omics analyses as a new analytical method.
Accelerating digital health literacy for the treatment of growth disorders: The impact of a massive open online course
Authors: Dimitri Paul , Fernandez-Luque Luis , Koledova Ekaterina , Malwade Shwetambara , Syed-Abdul Shabbir
Published: April 2023

Background

Growth hormone deficiency (GHD) is a rare disorder characterized by inadequate secretion of growth hormone (GH) from the anterior pituitary gland. One of the challenges in optimizing GH therapy is improving adherence. Using digital interventions may overcome barriers to optimum treatment delivery. Massive open online courses (MOOCs), first introduced in 2008, are courses made available over the internet without charge to a large number of people. Here, we describe a MOOC aiming to improve digital health literacy among healthcare professionals managing patients with GHD. Based on pre- and post-course assessments, we evaluate the improvement in participants’ knowledge upon completion of the MOOC.

Methods

The MOOC entitled ‘Telemedicine: Tools to Support Growth Disorders in a Post-COVID Era’ was launched in 2021. It was designed to cover 4 weeks of online learning with an expected commitment of 2 h per week, and with two courses running per year. Learners’ knowledge was assessed using pre- and post-course surveys via the FutureLearn platform.

Results

Out of 219 learners enrolled in the MOOC, 31 completed both the pre- and post-course assessments. Of the evaluated learners, 74% showed improved scores in the post-course assessment, resulting in a mean score increase of 21.3%. No learner achieved 100% in the pre-course assessment, compared with 12 learners (40%) who achieved 100% in the post-course assessment. The highest score increase comparing the pre- and the post-course assessments was 40%, observed in 16% of learners. There was a statistically significant improvement in post-course assessment scores from 58.1 ± 18.9% to 72.6 ± 22.4% reflecting an improvement of 14.5% (p < 0.0005) compared to the pre-course assessment.

Conclusion

This “first-of-its-kind” MOOC can improve digital health literacy in the management of growth disorders. This is a crucial step toward improving the digital capability and confidence of healthcare providers and users, and to prepare them for the technological innovations in the field of growth disorders and growth hormone therapy, with the aim of improving patient care and experience. MOOCs provide an innovative, scalable and ubiquitous solution to train large numbers of healthcare professionals in limited resource settings.
A longitudinal controlled signage intervention to increase stair use at university buildings: Process and impact evaluation using RE-AIM framework
Authors: Muttaqien Zaenal , Wasityastuti Widya , Sofyana Meida , Agustiningsih Denny , Wibowo Rakhmat Ari
Published: April 2023

Introduction

Stair climbing intervention could be suggested to address low occupational physical activity amongst university students and employees. Strong evidence showed the effectiveness of signage intervention in increasing stair use in public areas. However, evidence in worksite settings, including university settings, was inconclusive. This study aimed to evaluate the process and impact of a signage intervention to increase stair use at a university building using the RE-AIM framework.

Method

We conducted a non-randomised controlled pretest-posttest study to examine the effect of signage intervention placed in university buildings in Yogyakarta (Indonesia) between September 2019 and March 2020. The process of designing the signage involved the employees in the intervention building. The main outcome was the change in the proportion of stair use to elevator use measured by manual observations of video recordings from closed-circuit television. A linear mixed model examined the intervention effect by controlling the total visitor count as a confounder. RE-AIM framework was used in the process and impact evaluation.

Results

The change in the proportion of stair climbing from baseline to the 6th-month phase at the intervention building (+0.067 (95% CI = 0.014–0.120)) was significantly higher than that of the control building. However, the signs did not change the proportion of the stair descending at the intervention building. The signs were potentially viewed 15,077–18,868 times/week by visitors.

Conclusion

Signage intervention using portable posters could easily be adopted, implemented, and maintained in similar settings. A co-produced low-cost signage intervention was found to have a good reach, effectiveness, adoption, implementation, and maintenance dimension.
Mapping health assessment questionnaire disability index onto EQ-5D-5L in China
Authors: Wan Chuchuan , Wang Qiqi , Xu Zhaoqi , Huang Yuankai , Xi Xiaoyu
Published: April 2023

Objective

This research aimed to develop the more accurate mapping algorithms from health assessment questionnaire disability index (HAQ-DI) onto EQ-5D-5L based on Chinese Rheumatoid Arthritis patients.

Methods

The cross-sectional data of Chinese RA patients from 8 tertiary hospitals across four provincial capitals was used for constructing the mapping algorithms. Direct mapping using Ordinary least squares regression (OLS), the general linear regression model (GLM), MM-estimator model (MM), Tobit regression model (Tobit), Beta regression model (Beta) and the adjusted limited dependent variable mixture model (ALDVMM) and response mapping using Multivariate Ordered Probit regression model (MV-Probit) were carried out. HAQ-DI score, age, gender, BMI, DAS28-ESR and PtAAP were included as the explanatory variables. The bootstrap was used for validation of mapping algorithms. The average ranking of mean absolute error (MAE), root mean square error (RMSE), adjusted R2 (adjR2) and concordance correlation coefficient (CCC) were used to assess the predictive ability of the mapping algorithms.

Results

According to the average ranking of MAE, RMSE, adjR2, and CCC, the mapping algorithm based on Beta performed the best. The mapping algorithm would perform better as the number of variables increasing.

Conclusion

The mapping algorithms provided in this research can help researchers to obtain the health utility values more accurately. Researchers can choose the mapping algorithms under different combinations of variables based on the actual data.
The impact of the COVID-19 pandemic on nosocomial infections: a retrospective analysis in a tertiary maternal and child healthcare hospital
Authors: Huang Huifang , Wu Kunhai , Chen Haiming , Wang Jing , Chen Lufei , Lai Zhirun , Lin Shuling
Published: April 2023

Objective

The constant changes in the control strategies of the Corona Virus Disease 2019 (COVID-19) pandemic have greatly affected the prevention and control of nosocomial infections (NIs). This study assessed the impact of these control strategies on the surveillance of NIs in a regional maternity hospital during the COVID-19 pandemic.

Methods

This retrospective study compared the observation indicators of nosocomial infections and their changing trends in the hospital before and during the COVID-19 pandemic.

Results

In total, 2,56,092 patients were admitted to the hospital during the study. During the COVID-19 pandemic, the main drug-resistant bacteria in hospitals were Escherichia coli, Streptococcus agalactiae, Staphylococcus aureus, Klebsiella pneumoniae, and Enterococcus faecalis. The detection rate of S. agalactiae increased annually, while that of E. faecalis remained the same. The detection rate of multidrug-resistant bacteria decreased during the pandemic (16.86 vs. 11.42%), especially that of CRKP (carbapenem-resistant Klebsiella pneumoniae 13.14 vs. 4.39, P < 0.001). The incidence of nosocomial infections in the pediatric surgery department decreased significantly (OR: 2.031, 95% CI: 1.405–2.934, P < 0.001). Regarding the source of infection, a significant reduction was observed in respiratory infections, followed by gastrointestinal infections. In the routine monitoring of the ICU, the incidence of central line-associated bloodstream infection (CLABSI) decreased significantly (9.4/1,000 catheter days vs. 2.2/1,000 catheter days, P < 0.001).

Conclusion

The incidence of nosocomial infections was lower than that before the COVID-19 pandemic. The prevention and control measures for the COVID-19 pandemic have reduced the number of nosocomial infections, especially respiratory, gastrointestinal, and catheter-related infections.
Disparities in spatial accessibility of primary care in Louisiana: From physical to virtual accessibility
Authors: Wang Fahui , Zeng Yutian , Liu Lingbo , Onega Tracy
Published: April 2023

Telehealth has been widely employed and has transformed how healthcare is delivered in the United States as a result of COVID-19 pandemic. While telehealth is utilized and encouraged to reduce the cost and travel burden for access to healthcare, there are debates on whether telehealth can promote equity in healthcare services by narrowing the gap among diverse groups. Using the Two-Step Floating Catchment Area (2SFCA) and Two-Step Virtual Catchment Area (2SVCA) methods, this study compares the disparities of physical and virtual access to primary care physicians (PCPs) in Louisiana. Both physical and virtual access to PCPs exhibit similar spatial patterns with higher scores concentrated in urban areas, followed by low-density and rural areas. However, the two accessibility measures diverge where broadband availability and affordability come to play an important role. Residents in rural areas experience additive disadvantage of even more limited telehealth accessibility than physical accessibility due to lack of broadband service provision. Areas with greater Black population proportions tend to have better physical accessibility, but such an advantage is eradicated for telehealth accessibility because of lower broadband subscription rates in these neighborhoods. Both physical and virtual accessibility scores decline in neighborhoods with higher Area Deprivation Index (ADI) values, and the disparity is further widened for in virtual accessibility compared to than physical accessibility. The study also examines how factors such as urbanicity, Black population proportion, and ADI interact in their effects on disparities of the two accessibility measures.
Field investigation of the heat stress in outdoor of healthcare workers wearing personal protective equipment in South China
Authors: Zhu Yongcheng , Mao Yudong , Li Yanling , Tang Tianwei , Jiang Huilin , Qiao Sicheng , Lin Shaopeng , Zheng Zhimin , Fang Zhaosong , Chen Xiaohui
Published: April 2023

Since the advent of coronavirus disease 2019 (COVID-19), healthcare workers (HCWs) wearing personal protective equipment (PPE) has become a common phenomenon. COVID-19 outbreaks overlap with heat waves, and healthcare workers must unfortunately wear PPE during hot weather and experience excessive heat stress. Healthcare workers are at risk of developing heat-related health problems during hot periods in South China. The investigation of thermal response to heat stress among HCWs when they do not wear PPE and when they finish work wearing PPE, and the impact of PPE use on HCWs’ physical health were conducted. The field survey were conducted in Guangzhou, including 11 districts. In this survey, HCWs were invited to answer a questionnaire about their heat perception in the thermal environment around them. Most HCWs experienced discomfort in their back, head, face, etc., and nearly 80% of HCWs experienced “profuse sweating.” Up to 96.81% of HCWs felt “hot” or “very hot.” The air temperature had a significant impact on thermal comfort. Healthcare workers’ whole thermal sensation and local thermal sensation were increased significantly by wearing PPE and their thermal sensation vote (TSV) tended towards “very hot.” The adaptive ability of the healthcare workers would decreased while wearing PPE. In addition, the accept range of the air temperature (Ta) were determined in this investigation.
Study on the mechanism of urban morphology on river cooling effect in severe cold regions
Authors: Guo Fei , Xu Sheng , Zhao Jun , Zhang Hongchi , Liu Lijuan , Zhang Zhen , Yin Xinyuan
Published: April 2023

In the context of global warming, urban climate problems such as heat waves, urban heat islands and air pollution are becoming increasingly prominent, and the cooling effect of rivers is an effective way to mitigate urban hot climate. This study investigates the surrounding urban area of the Hun River in Shenyang, a severe cold region of China, by calculating satellite inversion surface temperature and urban morphology data, and explores the cooling effect of rivers using linear regression models and spatial regression models. The results show that (1) water bodies have a cooling effect on the surrounding environment, with the farthest cooling distance being 4,000 m, but the optimal cooling distance being 2,500 m. (2) In the results of the spatial regression model analysis, the R2 value stays above 0.7 in the range of 0–4,000 m, indicating that urban morphological factors are closely related to LST (land surface temperature). The negative correlation is most pronounced for NVDI (normalized vegetation index), with a peak of −14.8075 calculated by the regression model, and the positive correlation is most pronounced for BD (building density), with a peak of 8.5526. (3) The urban thermal environment can be improved and the heat island effect mitigated through measures such as increasing urban vegetation cover and reducing building density, and these findings can provide data references and case studies to support urban planning and development departments.
Motivation states to move, be physically active and sedentary vary like circadian rhythms and are associated with affect and arousal
Authors: Budnick Christopher J. , Stults-Kolehmainen Matthew , Dadina Cyrus , Bartholomew John B. , Boullosa Daniel , Ash Garret I. , Sinha Rajita , Blacutt Miguel , Haughton Adrian , Lu Tom
Published: April 2023

Introduction

Motivation to be physically active and sedentary is a transient state that varies in response to previous behavior. It is not known: (a) if motivational states vary from morning to evening, (b) if they are related to feeling states (arousal/hedonic tone), and (c) whether they predict current behavior and intentions. The primary purpose of this study was to determine if motivation states vary across the day and in what pattern. Thirty adults from the United States were recruited from Amazon MTurk.

Methods

Participants completed 6 identical online surveys each day for 8 days beginning after waking and every 2–3 h thereafter until bedtime. Participants completed: (a) the CRAVE scale (Right now version) to measure motivation states for Move and Rest, (b) Feeling Scale, (c) Felt Arousal Scale, and (d) surveys about current movement behavior (e.g., currently sitting, standing, laying down) and intentions for exercise and sleep. Of these, 21 participants (mean age 37.7 y; 52.4% female) had complete and valid data.

Results

Visual inspection of data determined that: a) motivation states varied widely across the day, and b) most participants had a single wave cycle each day. Hierarchical linear modelling revealed that there were significant linear and quadratic time trends for both Move and Rest. Move peaked near 1500 h when Rest was at its nadir. Cosinor analysis determined that the functional waveform was circadian for Move for 81% of participants and 62% for Rest. Pleasure/displeasure and arousal independently predicted motivation states (all p's < .001), but arousal had an association twice as large. Eating, exercise and sleep behaviors, especially those over 2 h before assessment, predicted current motivation states. Move-motivation predicted current body position (e.g., laying down, sitting, walking) and intentions for exercise and sleep more consistently than rest, with the strongest prediction of behaviors planned for the next 30 min.

Discussion

While these data must be replicated with a larger sample, results suggest that motivation states to be active or sedentary have a circadian waveform for most people and influence future behavioral intentions. These novel results highlight the need to rethink the traditional approaches typically utilized to increase physical activity levels.
Kinematic and kinetic comparison between preprofessional pitchers from the Dominican Republic and the United States
Authors: Nicholson Kristen F. , Mylott Joseph A. , Hulburt Tessa C. , Hamer Tyler J. , Bullock Garrett S.
Published: April 2023

Introduction

Pitching biomechanical efficiency is defined as the association between pitch velocity and arm kinetics. Pitching mechanics inefficiency, an increase in arm kinetics without the resultant increase in pitch velocity, can lead to increased arm strain, increasing arm injury risk. The purpose of this study was to compare arm kinetics, elbow varus torque and shoulder force, in preprofessional United States (US) and Dominican Republic (DR) pitchers. Kinematics that are known to influence elbow varus torque and shoulder force as well as a representative of pitch velocity (hand velocity) were also compared.

Methods

A retrospective review was performed on baseball pitchers from the DR and US who participated in biomechanical evaluations conducted by the University biomechanics laboratory personnel. Three-dimensional biomechanical analyses were performed on US (n = 37) and DR (n = 37) baseball pitchers. Potential differences between US and DR pitchers were assessed through analysis of covariance with 95% confidence intervals [95% confidence Interval (CI)].

Results

Preprofessional DR pitchers experienced increased elbow varus torque compared with their US counterparts [DR: 7.5 (1.1); US: 5.9 (1.1) %BWxH; Beta: −2.0 (95% CI: −2.7, −1.2) %BWxH], despite throwing fastballs with slower hand velocity [DR: 3,967.1 (939.4); US: 5,109.1 (613.8) °/s; Beta: 1,129.5 (95% CI: 677.5, 1,581.4) °/s]. DR and US pitchers demonstrated similar shoulder force [DR: 136.8 (23.8); US: 155.0 (25.7); Beta: 0.4 (95% CI: −1.2, 19.7) %BW].

Discussion

Increased elbow varus torque although decreased hand velocity suggests inefficient pitching mechanics among DR pitchers. Inefficient pitching mechanics and increased elbow torque should be considered when developing training programs and pitching plans for professional pitchers from the Dominican Republic.
Development of organic nutrients management system for profitable and soil-supportive French bean (Phaseolus vulgaris L.) farming in North Eastern Himalayas, India
Authors: Singh Raghavendra , Kumar Amit , Babu Subhash , Avasthe Ravikant , Das Anup , Rathore Sanjay Singh , Kumar Sanjeev , Singh Chandu , Sharma Vikas , Bhupenchandra Ingudam
Published: April 2023

French bean (Phaseolus vulgarisL.) cultivation faces multipronged challenges of low farm productivity, poor economic returns, and soil health deterioration in the hilly ecosystem of India. Hence, the development of a cost-effective and soil-supportive French bean cultivation technology is highly warranted. Thus, a field experiment was conducted for two consecutive seasons in the Sikkim region of the Indian Himalayas to assess the impact of different organic nutrient sources on the production potential, profitability, and soil health of French bean. Eight organic nutrient management practices,viz., farmers' practice, 100% recommended dose of nitrogen (RDN) through FYM, 100% RDN through mixed compost (MC), 100% RDN through vermicompost (VC), 50% RDN through FYM + 50% RDN through MC, 50% RDN through FYM + 50% RDN through VC, 50% RDN through MC + 50% RDN through VC, and 33% RDN through FYM + 33% RDN through MC + 33% RDN through VC, were assigned in a three times replicated randomized complete block design. The results revealed that the supply of 33% RDN through FYM + 33% RDN through MC + 33% RDN through VC 33% recorded the highest pod yield (8.30 and 8.00 Mg ha−1) and net returns (1,831 and 1,718 US$ ha−1). Furthermore, the supply of 33% RDN through FYM + 33% RDN through MC + 33% RDN through VC 33% also had a positive impact on soil health. It was shown that an equal supply of RDN through FYM + MC + VC increases soil pH by 8.35%, SOC by 5.45%, available N by 6.32%, available P by 16%, available K by 9.92%, and micronutrients by 5–7% over farmers' practice. Thus, the supply of RDN through the integration of FYM + MC + VC in equal proportion is an economically robust and soil-supportive nutrients management practice for organic French bean production in the hilly ecosystem of North East India.
Impact of ergot alkaloid and steroidal implant on whole-body protein turnover and expression of mTOR pathway proteins in muscle of cattle
Authors: Ferguson Taylor D. , Loos Caroline M. M. , Vanzant Eric S. , Urschel Kristine L. , Klotz James L. , McLeod Kyle R.
Published: April 2023

Introduction

Holstein steers (n = 32) were used to determine if the ergot analog, bromocriptine decreases muscle protein synthesis through inhibitory action on the mTOR pathway via a direct effect on signal proteins, and if these negative effects can be alleviated with anabolic agents.

Methods

Steers were treated with intramuscular administration of bromocriptine (vehicle or 0.1 mg/kg BW) and a subdermal commercial steroidal implant containing trenbolone acetate (TBA) and estradiol 17β (with or without), in a 2×2 factorial design. During the 35 day experiment, intake was restricted to 1.5 times maintenance energy requirement. On days 27 through 32, steers were moved to metabolism stalls for urine collection, and whole-body protein turnover was determined using a single pulse dose of [15N] glycine into the jugular vein on day 28. On day 35, skeletal muscle samples were collected before (basal state) and 60 min after (stimulated state) an i.v. glucose challenge (0.25 g glucose/kg). Blood samples were collected at regular intervals before and after glucose infusion for determination of circulating concentrations of glucose and insulin.

Results

Bromocriptine reduced insulin and glucose clearance following the glucose challenge, indicating decreased insulin sensitivity and possible disruption of glucose uptake and metabolism in the skeletal muscle. Conversely, analysis of whole-body protein turnover demonstrated that bromocriptine does not appear to affect protein synthesis or urea excretion. Western immunoblot analysis of skeletal muscle showed that it did not affect abundance of S6K1 or 4E-BP1, so bromocriptine does not appear to inhibit activation of the mTOR pathway or protein synthesis. Estradiol/TBA implant decreased urea excretion and protein turnover but had no effect on protein synthesis, suggesting that steroidal implants promote protein accretion through unchanged rates of synthesis and decreased degradation, even in the presence of bromocriptine, resulting in improved daily gains. Implanted steers likely experienced increased IGF-1 signaling, but downstream activation of mTOR, S6K and 4E-BP1, and thus increased protein synthesis did not occur as expected.

Conclusions

Overall, this data suggests that bromocriptine does not have a negative impact on muscle protein synthetic pathways independent of DMI.
Finisher lamb growth and rumen fermentation responses to the plane of nutrition and naturally occurring coccidiosis
Authors: Sujani Sathya , dos Reis Barbara R. , Ellett Mark D. , Schramm Holly H. , Helm Emma T. , White Robin R.
Published: April 2023

The objective of the present study was to investigate the interaction of plane of nutrition and naturally occurring coccidiosis on finisher lamb growth performance, FAMACHA score, and rumen volatile fatty acid profile. The study included 30 Suffolk, Dorset or Suffolk x Dorset lambs and were divided into 2 groups based on their initial body weight and assigned to 2 feeding groups differing in dietary energy intake to create lambs representing divergent growth curves due to differing nutritional management. Lambs with naturally occurring coccidiosis and healthy lambs were present in both feeding groups making a 2 × 2 factorial arrangement of treatments, (a) high plane of nutrition (HPN) lambs with no clinical coccidiosis diagnosis (HPNH), (b) HPN lambs with clinical coccidiosis (HPNC), (c) low plane of nutrition (LPN) lambs with no clinical coccidiosis diagnosis (LPNH), (d) LPN lambs with clinical coccidiosis (LPNC). Body weight and FAMACHA scores were recorded once every 2 weeks. On d 65 of feeding, lambs were slaughtered, and rumen fluid samples were collected and analyzed for volatile fatty acid concentrations. All response variables were analyzed statistically using a linear mixed effects model with fixed effects for plane of nutrition, health status, and a random effect for initial body weight nested within the pen. The total and average weight gain were not associated with planes of nutrition, health status, or the interaction. Health status had an impact on FAMACHA© score (P = 0.047) and concentration of isobutyrate (P = 0.037) and tended to affect total VFA (P = 0.085) and acetate (P = 0.071) concentrations. The interaction between the plane of nutrition and the health status tended to affect butyrate concentration (P = 0.058). These data support the conclusion that coccidiosis infection impacted on rumen fermentation in a manner independent of the plane of nutrition; however, the translation of these rumen level impacts did not translate to the production responses.
Model-Robust Estimation of Multiple-Group Structural Equation Models
Authors: Robitzsch Alexander
Published: April 2023

Structural equation models (SEM) are widely used in the social sciences. They model the relationships between latent variables in structural models, while defining the latent variables by observed variables in measurement models. Frequently, it is of interest to compare particular parameters in an SEM as a function of a discrete grouping variable. Multiple-group SEM is employed to compare structural relationships between groups. In this article, estimation approaches for the multiple-group are reviewed. We focus on comparing different estimation strategies in the presence of local model misspecifications (i.e., model errors). In detail, maximum likelihood and weighted least-squares estimation approaches are compared with a newly proposed robust Lp loss function and regularized maximum likelihood estimation. The latter methods are referred to as model-robust estimators because they show some resistance to model errors. In particular, we focus on the performance of the different estimators in the presence of unmodelled residual error correlations and measurement noninvariance (i.e., group-specific item intercepts). The performance of the different estimators is compared in two simulation studies and an empirical example. It turned out that the robust loss function approach is computationally much less demanding than regularized maximum likelihood estimation but resulted in similar statistical performance.