bluuebunny/crossref_metadata_2025 huggingface dataset:
Decision-making, aggression, age, and type of crime as predictors of coping among young adult male maximum-security incarcerated offenders
Authors: Pretorius Sheree Elizabeth , Jordaan Jacques , Esterhuyse Karel
Published: January 2022

Correctional environments are regarded as degrading, dangerous, difficult, stigmatizing, stressful, unsafe, and violent. Young adult male incarcerated offenders need to acquire the necessary coping skills to survive in the correctional environment. This research study aimed to determine which variable(s) or set of variables explain a significant percentage of the variance in coping among young adult male incarcerated offenders in a South African private maximum-security correctional center. The research approach in this study was quantitative, and the nature of the research was nonexperimental. A correlational research design was used. The sample consisted of 187 young adult male incarcerated offenders. The hierarchical regression analysis results indicated that vigilance was the only predictor variable that statistically and practically significantly predicted seeking social support and problem-solving. This finding implies that young adult offenders who are more vigilant regarding decision-making are more inclined to solve problems better and use social support to cope better.
Intervención para modificar hábitos alimentarios en los refrigerios de escolares de una ciudad fronteriza México / Estados Unidos
Authors: Alemán-Castillo SanJuana Elizabeth , Perales-Torres Adriana Leticia , González-Pérez Ana Luisa , Ríos-Reyna Candelaria , Bacardí-Gascón Montserrat , Jiménez-Cruz Arturo , Castillo-Ruiz Octelina
Published: January 2022

Resumen:

El objetivo del presente estudio fue evaluar el efecto de una intervención en educación nutricional como estrategia para modificar la calidad de los refrigerios escolares de acuerdo con los estándares gubernamentales. Se evaluaron alumnos de 12 escuelas primarias públicas de nivel socioeconómico medio. Se formó un grupo intervención (GI) y un grupo control (GC), con seguimiento durante dos años. En ambos grupos se tomaron mediciones de peso, estatura y circunferencia de cintura. Se registró, durante cinco días consecutivos, los alimentos incluidos en la lonchera de los niños, previa firma de un consentimiento informado de los padres. Durante la intervención se realizaron pláticas sobre alimentación en el salón de clase para los escolares y a los padres de familia se les entregaron folletos sobre recomendaciones de un refrigerio adecuado. En el GC solo se entregaron folletos sin tener contacto con alumnos y padres de familia. Al final de la intervención, el GI disminuyó calorías ( p = 0.001), proteínas ( p = 0.01), carbohidratos ( p = 0.008) y azúcar ( p = 0.0001); mientras que en el GC disminuyó el contenido de carbohidratos y azúcar. Además, el GI aumentó el consumo de cereales integrales, verduras, frijoles y pan integral. En conclusión, la escuela es el lugar ideal para realizar intervenciones a largo plazo, sin embargo, es necesario promover la incorporación de profesionales de la salud (nutriólogos) con programas y actividades planeadas durante los seis años de primaria.
Discrimination of 11 Malaysian Durian Cultivars Based on Sulfur-Containing Volatiles and Esters Using Multivariate Data Analysis
Authors: Osman Che Puteh , Kasim Noraini , Mohamed Salim Nur Syamimi Amirah , Abdul Aziz Nuralina
Published: January 2022

There are reports documenting the volatile oils of several durian cultivars in Malaysia. However, there is limited information on the rapid discrimination of the durian cultivars based on the composition of the total volatiles and individual volatile compounds. Thus, the present work aims to discriminate 11 Malaysian durian cultivars based on their volatile compositions using multivariate data analysis. Sulfur-containing volatiles are the major volatiles in D175 (Udang Merah), D88 (Darling), D13 (Golden Bun), DXO (D24 Special), D17 (Green Bamboo), D2 (Dato Nina), and D168 (Hajah Hasmah) durian cultivars, while esters are predominant in D99 (Kop Kecil), D24 (Bukit Merah), and D160 (Musang Queen) durian cultivars. D197 (Musang King) cultivar has an almost equal composition of sulfur-containing volatiles and esters. In the ester predominated volatile durian oil, ethyl 2-methylbutanoate and propyl 2-methylbutanoate are the major volatile compounds, while the durian cultivars with predominant sulfur-containing volatiles mainly contain diethyl disulfide, diethyl trisulfide, and 3,5-dimethyl-1,2,4-trithiolane. The durian cultivars were clustered into 8 clusters using principal component analysis, with 3 clusters consisting of 2 cultivars, and with the remaining cultivars clustered individually. The highly sought-after durian cultivars, D160 and D197, were clustered into one. Hierarchal clustering analysis identified the distinct compounds which discriminate every durian cultivar.
Efficient Isolation and Structure Analysis of (+)-Ranuncoside, a Unique Tricyclic Spiroacetal Glycoside, from Christmas Rose (Helleborus niger L.)
Authors: Cuny Eckehard , Klingler Franz-Dietrich
Published: January 2022

The use of medicinal herbs as remedies reaches back to the Stone Age, and their importance as a source of drugs has continuously increased since then. Herbal ingredients can serve as active pharmaceuticals themselves or as lead substances for the development of synthetic pharmaceuticals with less toxicity, higher effectiveness or with new properties. To date, only 6% of the ∼600,000 plants on earth have been tested pharmacologically. Among these, the medicinal plant Helleborus niger L. (Christmas rose) is especially promising because its leaves contain ( + )-ranuncoside 1, characterized by a spiroacetal ring system, a motif which is responsible for the biological activity of a multitude of natural products. Structure-activity relationship studies of ( + )-ranuncoside 1 are lacking and no synthesis of 1 has been described yet. Therefore, we developed a protocol for the rapid and efficient isolation of 1 from the leaves of cultivated Christmas rose. Crystals of high purity were obtained that enabled us to study the stereochemistry of 1 by NMR spectroscopy in solution for the first time. The spiro configuration, the absolute stereochemistry, and the geometry of all three rings was then confirmed by x-ray structure analysis. Our data will enable future structure-activity relationship studies to assess the potential of 1 as a lead substance for the development of novel antibiotics and anticancer agents.
Developing the Women’s health strategy: The British Menopause Society’s recommendations to the department of health and social care’s call for evidence
Authors: Hamoda Haitham , Moger Sara ,   On behalf of the Board of Trustees and Medical Advisory Council of the British Menopause Society
Published: January 2022

In the early part of 2021, the government launched a call for evidence to inform the development of the Women’s Health Strategy with the objective of better understanding women’s experiences of the health and care system and to help improve the health and wellbeing of women. The British Menopause Society Medical Advisory Council and the BMS Board of Trustees recommendations specific to the menopause and post reproductive health in relation to all six core themes included in the call for evidence assessing the different areas of women’s health are discussed in this document
Let's talk about sex(ual) wellbeing! Staff perceptions of implementing a novel service for people with Multiple Sclerosis
Authors: Jarvis Laura , McConville Kevin , Devereux Sonia , O’Riordan Jonathan
Published: January 2022

Background

In people with multiple sclerosis (PwMS), a complex interplay of neurological dysfunction, polypharmacy and psychological issues, contrive to impair their sexual and reproductive wellbeing. Realising an unmet need, the Tayside MS service in collaboration with a sexual health clinician (LJ), established a ‘Pelvic Health Clinic’ to improve quality of life for PwMS.

Objective

To explore clinician's perceptions of implementing an MS Pelvic Health service with a view to establishing future outcomes for health care professionals about the utility in such a service.

Method

In this small-scale qualitative case study, we explored clinician's perceptions of such a clinic adjunct. Semi-structured interviews were conducted, transcribed, and thematically analysed in a reflexive manner.

Results

Five participants consented. Ten sub-themes emerged, which were organised into three main themes: service tensions, patient needs and practitioner feelings.

Conclusion

Clinicians highly valued the new MS ‘pelvic health clinic’. Knowing that there was a service available empowered clinicians to ask patients about sexual health needs. Specific referral criteria may help further develop the service and improve patient care. Staff welcome training and support in this area or the option to signpost onwards; either mechanism lends itself to enhancing MS patient needs.
General theory of legal design in law and economics framework of commercial contracting
Authors: Nousiainen Katri
Published: January 2022

We need law and economics to do the scientific measurement necessary for legal design to be seen as on the stage of science. Law and economics—which is the application of economic theory, especially microeconomic theory, to the analysis and the practice of law--is a valid tool and approach to reflect on what should be empirically investigated in the practice of legal design. The neoclassical (mainstream) theoretical foundation of economic analysis of law is, however, at times far from reality as it often predicts uncooperative and even selfish behaviour. In real life people do cooperate, have empathy, emotions and even behave in an altruistic way. For those reasons, behavioural law and economics and conventional wisdom are needed to complement the teachings from standard theory in the field of commercial contracting.
Cardioprotective effects of alantolactone on isoproterenol-induced cardiac injury and cobalt chloride-induced cardiomyocyte injury
Authors: Liu Miaomiao , Liu Panpan , Zheng Bin , Liu Yu , Li Li , Han Xue , Liu Yangshuang , Chu Li
Published: January 2022

Objectives

Alantolactone (AL) is a compound extracted from the roots of Inula Racemosa that has shown beneficial effects in cardiovascular disease. However, the cardioprotective mechanism of AL against hypoxic/ischemic (H/I) injury is still unclear. This research aimed to determine AL’s ability to protect the heart against isoproterenol (ISO)-induced MI injury in vivo and cobalt chloride (CoCl2) induced H/I injury in vitro.

Methods

Electrocardiography (ECG), lactate dehydrogenase (LDH), creatine kinase (CK), and cardiac troponin I (cTnI) assays in addition to histological analysis of the myocardium were used to investigate the effects of AL in vivo. Influences of AL on L-type Ca2+ current (ICa-L) in isolated rat myocytes were observed by the patch-clamp technique. Furthermore, cell viability, apoptosis, oxidative stress injury, mitochondrial membrane potential, and intracellular Ca2+ concentration were examined in vitro.

Results

The results indicated that AL treatment ameliorated the morphological and ECG changes associated with MI, and decreased levels of LDH, CK, and cTnI. Furthermore, pretreatment with AL elevated antioxidant enzyme activity and suppressed ROS production. AL prevented H/I-induced apoptosis, mitochondria damage, and calcium overload while reducing ICa-L in a concentration and time dependent fashion. The 50% inhibiting concentration (IC50) and maximal inhibitory effect (Emax) of AL were 17.29 μmol/L and 57.73 ± 1.05%, respectively.

Conclusion

AL attenuated MI-related injury by reducing oxidative stress, apoptosis, calcium overload, and mitochondria damage. These cardioprotective effects may be related to the direct inhibition of ICa-L.
Nitric oxide synthase-2 (CCTTT)n polymorphism is associated with local gene expression and clinical manifestations in patients with chronic rhinosinusitis
Authors: Takemoto Kota , Takeno Sachio , Ishino Takashi , Ueda Tsutomu , Hamamoto Takao , Horibe Yuichiro , Takahara Daisuke , Kawasumi Tomohiro
Published: January 2022

Introduction

Nitric oxide (NO) is synthesized through NO synthase (NOS). The proximal NOS2 gene promoter contains the pentanucleotide CCTTT repeat polymorphism. We examined whether CCTTT repeats are associated with NOS2 expression in the sinonasal tissues and clinical manifestations in patients with chronic rhinosinusitis.

Methods

Mucosal specimens were obtained from the ethmoid sinus and inferior turbinate of 30 eosinophilic chronic rhinosinusitis (ECRS) and 28 non-ECRS patients. CCTTT repeats were classified into short alleles (S), with less than or equal to 14, and long alleles (L), with more than 14. The subjects were classified into the L/S + L/L and S/S groups.

Results

In ECRS, the NOS2 mRNA levels of the ethmoid sinus mucosa were significantly higher in the L/S + L/L group than in the S/S group (median, 1.66 and 0.77, respectively). On the ther hand, ECRS patients showed no significant difference in the NOS2 mRNA level of the inferior turbinate between the L/S + L/L group and the S/S group (median, 0.63 and 0.88, respectively). In ECRS, preoperative SNOT-22 were significantly higher in the L/S + L/L group than in the S/S group, whereas the former group showed a lower postoperative recurrence risk.

Conclusion

CCTTT repeat polymorphism in the NOS2 promotor gene may be a useful indicator to evaluate ECRS severity and prognosis.
Symptoms COVID 19 Positive Vapers Compared to COVID 19 Positive Non-vapers
Authors: McFadden David D. , Bornstein Shari L. , Vassallo Robert , Salonen Bradley R. , Bhuiyan Mohammed Nadir , Schroeder Darrell R. , Croghan Ivana T.
Published: January 2022

Objectives:

The purpose of the present study was to assess and describe the severity of symptoms reported by Covid-19 positive patients who vaped (smoked e-cigarettes) when compared to those who did not vape or smoke at the time of the diagnosis of Covid-19.

Methods:

Patients from this study are from a well-characterized patient cohort collected at Mayo Clinic between March 1, 2020 and February 28, 2021; with confirmed COVID-19 diagnosis defined as a positive result on reverse-transcriptase–polymerase-chain-reaction (RT-PCR) assays from nasopharyngeal swab specimens. Among the 1734 eligible patients, 289 patients reported current vaping. The cohort of vapers (N = 289) was age and gender matched to 1445 covid-19 positive patients who did not vape. The data analyzed included: date of birth, gender, ethnicity, race, marital status, as well as lifestyle history such as vaping and smoking and reported covid-19 symptoms experienced.

Results:

A logistic regression analysis was performed separately for each symptom using generalized estimating equations (GEE) with robust variance estimates in order to account for the 1:5 age, sex, and race matched set study design. Patients who vaped and developed Covid-19 infection were more likely to have chest pain or tightness (16% vs 10%, vapers vs non vapers, P = .005), chills (25% vs 19%, vapers vs non vapers, P = .0016), myalgia (39% vs 32%, vapers vs non vapers, P = .004), headaches (49% vs 41% vapers vs non vapers, P = .026), anosmia/dysgeusia (37% vs 30%, vapers vs non vapers, P = .009), nausea/vomiting/abdominal pain (16% vs 10%, vapers vs non vapers, P = .003), diarrhea (16% vs 10%, vapers vs non vapers, P = .004), and non-severe light-headedness (16% vs 9%, vapers vs non vapers, P < .001).

Conclusion:

Vapers experience higher frequency of covid-19 related symptoms when compared with age and gender matched non-vapers. Further work should examine the impact vaping has on post-covid symptom experience.
Factors Associated With Disordered Eating Behavior Among Adolescent Girls: Screening and Education
Authors: Dunn Catherine P. , Riley Joan B. , Hawkins Kirsten B. , Tercyak Kenneth P.
Published: January 2022

Introduction/Objectives:

An unhealthy relationship with food can lead to disordered eating in adolescence, highlighting the importance of screening. This study describes the frequency of disordered eating behavior among female adolescents, as well as associated characteristics and health behaviors.

Methods:

Data are from a multidimensional risk factor screening survey administered at a university medical center’s adolescent clinic from 2016 to 2018. The instrument was adapted from existing screening tools such as the Rapid Assessment for Adolescent Preventive Services (RAAPS), the American Medical Association’s Guidelines for Adolescent Preventive Services (GAPS), and the Youth Risk Behavior Survey (YRBS). Analysis was limited to self-reported responses provided by females aged 10 to 21 years (N = 915). Statistical analyses included chi-square tests and independent sample T-tests.

Results:

Of the N = 915 females who reported on disordered eating behavior, n = 57 (6.2%) had engaged in some form of disordered eating behavior within the past 12 months. Disordered eating was significantly associated ( P < .001) with not consistently wearing a helmet while biking, having tried e-cigarettes, being bullied in the past 30 days, having an adverse childhood experience (ACE), and being African American ( P = .005). Subgroup analysis of the relationship between disordered eating and bullying, by race, yielded significant findings: disordered eating was more highly associated with being bullied in the past 30 days among African American females ( P = .038). The relationship between disordered eating and ACE was also significant ( P < .001) among Caucasian girls when stratified by race.

Conclusions:

Adolescent risk behaviors often co-occur, and disordered eating behavior may be differentially observed by race. Findings highlight the importance of education and screening to prevent the development of disordered eating, and identify those who may be struggling. These results can be useful to community health education and in healthcare to develop and implement health promotion and eating disorder prevention strategies. Further studies are needed to assess additional factors that promote or protect against disordered eating to improve prevention.
A Covid -19 Virtual Ward Model: A Preliminary Retrospective Clinical Evaluation From a UK District General Hospital
Authors: O’Malley Emily-Jane , Hansjee Shanil , Abdel-Hadi Basil , Kendrick Elizabeth , Lok She
Published: January 2022

Objective:

This study aims to evaluate the safety, utilization, ability to reduce length of hospitalization and overall outcomes of a COVID-19 virtual ward providing ongoing treatment at home.

Method:

A retrospective single-center study of patients discharged to the COVID-19 virtual “step down” ward between January 27th 2021 and March 2nd 2021. The referral process, length of hospitalization, length of stay on the virtual ward, readmissions, and ongoing treatment requirements including supplemental oxygen, antibiotics, and/or steroids were all noted.

Results:

A total of 50 patients were referred to the virtual ward. 43 referrals were accepted, 39 of which were from the respiratory ward. Four patients were readmitted, all due to hypoxia. All readmissions occurred within 5 days of discharge. 72% (n = 31) were discharged home with an ongoing oxygen requirement. 14.3% of patients were discharged with antibiotics only, 9.5% with steroids only and 23.8% with both antibiotics and steroids. The mean length of hospital stay for patients discharged to the virtual ward was 10.3 ± 9.7 days and 11.9 ± 11.6 days for all covid positive patients during this time. On average, patients spent 13.7 ± 7.3 days on the virtual ward. The average number of days spent on oxygen on the virtual ward was 11.6 ± 6.0 days.

Conclusion:

The virtual ward model exemplifies the potential benefits of collaborative working between primary and secondary care services, relieving pressure on hospitals whilst providing ongoing treatments at home such as supplemental oxygen. It also facilitates an early supported discharge of clinically stable patients with an improving clinical trajectory by managing them in the community.
Incidence of Obesity at 1 and 3 Years Among Community Dwelling Adults: A Population-Based Study
Authors: DeJesus Ramona S. , Croghan Ivana T. , Jacobson Debra J. , Fan Chun , St. Sauver Jennifer
Published: January 2022

Objective:

This study determined the incidence rates for obesity among adult patients ages 20 and older empaneled in primary care practice in Midwest United States to potentially identify an optimum timeframe for initiating intervention.

Background:

Primary care practice patients are likely to reflect underlying community trends in overweight and obesity; however, data on overweight and obesity in primary care patients is limited. While childhood incidence rates of obesity have been well reported, there is still a paucity of data on the incidence of obesity among adult population; literature has mainly focused on its prevalence.

Methods:

Medical record review of identified cohort with BMI data was conducted. Population was stratified by age and sex and overweight category was subdivided into tertiles.

Results:

Majority of 40 390 individuals who comprised the final population and had follow-up data, consisted of adults ages 40 to 69 years (47.5%), female (59.8%) of non-Hispanic ethnicity (95.9%) with 21 379 (52.8%) falling in weight category of overweight. Incidence of obesity was 7% at 1 year and 16% at 3 years follow-up. Highest percentages of individuals who became obese at 1 and 3 years were in age category of 40 to 69 years among men and 20 to 39 years among women. In Cox regression analysis, there was statistically significant association to developing obesity among all tertile groups in the overweight category. Age and particularly gender appeared to be modifying factors to likelihood of developing obesity.

Conclusion:

Study results suggest that while obesity incidence is higher among certain age groups in both genders, middle-aged women, and men in all tertiles of overweight category are at highest risk and may be the optimum population to target for weight loss interventions. Findings support the initiation of population-based interventions before onset of obesity.
Systematic Regulation of Personal Information Rights in the Era of Big Data
Authors: Zhu FangBing , Song Zongyu
Published: January 2022

Big data has an important impact on people’s production and life. The existing legal and judicial protection, sanctions, and mechanisms for the enforcement of information rights have proved insufficient to stem the serious consequences of rampant leakage and illegal activity. Based on Information Full Life Cycle Theory, this article combines qualitative analysis with quantitative analysis, uses data from the Survey Report on App Personal Information Leakage released by China Consumers Association as an example, and finds that illegal access, illegal provisions, and illegal transactions have become important sources of personal information leakage. The main reasons for this problem include limitations of the technologies used, the falsification of informed consent, the lag of legislative protections, and a lack of administrative supervision. Systematic regulation of the right to protect personal information should include a variety of initiatives. First, it should be used to identify who to protect and how to protect them. Second, there needs to be a shift from identifiable subject regulations to risk control. Third, legislation needs to be comprehensive, entailing a shift from fragmented to systemic reforms. Fourth, protection efforts should include supervision, self-regulation, and management. Finally, the jurisdiction of legislation should extend across cyberspace and physical reality as a means to achieve a balance between effective protection and the reasonable use of personal information.
A randomized controlled trial of three different local anesthetic methods for minor hand surgery
Authors: Lee Sang Ki , Kim Woo-suk , Choy Won Sik
Published: January 2022

Purpose: Hemostasis and local anesthetic injection are essential for minor hand surgeries under local anesthesia (LA). Wide awake local anesthesia no tourniquet (WALANT) became popular for achieving hemostasis without a tourniquet. However, a recent study reported that injection is more painful than tourniquet use in minor hand surgery. Therefore, this study aimed to compare three LA methods that differ according to injection and hemostasis, namely, the combination of a tourniquet and buffered lidocaine solution (CTB), WALANT, and conventional LA. Methods: This randomized prospective single-center study included 169 patients who underwent minor hand surgery between 2017 and 2020. We randomly allocated the patients to each group and recorded the pain and anxiety score during the surgery, as well as satisfaction after the surgery. Results: Pure lidocaine injection was significantly more painful than buffered lidocaine and WALANT solution injection ( p < 0.001). Local anesthesia injection was significantly more painful than tourniquet use in all groups ( p < 0.001). The intraoperative anxiety score was significantly lower in the CTB group than in the conventional LA and WALANT groups ( p < 0.001). The satisfaction score was significantly higher in the CTB and WALANT groups than in the conventional LA group ( p < 0.001). Conclusion: CTB for minor hand surgery under LA is associated with less injection pain and patient anxiety. The tourniquet is tolerable without much pain and waiting time. Thus, CTB in minor hand surgery is a good alternative to WALANT and conventional LA.
Relationship Cultivation via Social Media During the COVID-19 Pandemic: Evidence From China and the U.S
Authors: Huang Qiongyao , Lynn Benjamin J. , Dong Chuqing , Ni Shijun , Men Linjuan Rita
Published: January 2022

This study explored the relationship cultivation and social media strategies companies used to cultivate relationships with their publics in two culturally distinct markets of China and the U.S. during the COVID-19 pandemic. A quantitative content analysis of Weibo ( n = 756) and Twitter ( n = 645) posts from Fortune 500 companies in China ( n = 30) and the U.S. ( n = 30) respectively was conducted to examine the effects of their relational efforts on public engagement. Results showed that certain relationship cultivation strategies and use of social media functions effectively increased public engagement in both China and the U.S., although on different levels. Both Chinese and U.S. companies most frequently adopted the strategy of openness. While the openness strategy was most effective at raising engagement levels in the U.S., publics of Chinese companies became more engaged when companies used the access strategy. Also, publics of Chinese companies showed higher levels of engagement and more positive emotions toward companies’ social media messages than their U.S. counterparts. The findings advance our understanding of organization-public relationships in a worldwide disaster setting, with insights informing the global public relations theory and practices.
Sleep Quality Among Informal Caregivers During the COVID-19 Pandemic: A Cross-Sectional Study
Authors: Greaney Mary L. , Kunicki Zachary J. , Drohan Meghan M. , Nash Caitlin C. , Cohen Steven A.
Published: January 2022

Sleep is an integral component of health. The impact of the COVID-19 pandemic on sleep quality among informal caregivers, individuals who provide unpaid care or assistance to family members or friends, assisting older adults is not well understood. Therefore, informal caregivers in the United States providing care for individuals aged 50+ were recruited via Amazon’s Mechanical Turk, an online platform for enrolling study participants into social and behavioral science research, to complete an online survey. The sample of informal caregivers ( n = 835) was 69% male and 55% non-Hispanic. Multivariable linear regression models were constructed to assess the associations between sleep disturbance scores (SDS) and sleep-related impairment scores (SIS) and caregiving-related measures (hours caregiving/week, length of time spent caregiving, and caregiver burden), demographics, and region of the United States. The analysis determined that Black (β = 2.6, 95% CI [−4.3, −0.9]) and Asian informal caregivers (β = −1.8, 95% CI [−3.4, −0.3]) had lower mean SIS than White caregivers, the referent group. In addition, increasing caregiver burden was associated with increased SDS (β = 0.8, 95% CI [0.6, 1.0]) and SIS (β = 1.3, 95% CI [0.7, 1.6]). In conclusion, higher caregiver burden was associated with higher SIS and SDS, suggesting that informal caregivers' sleep should be assessed, and when needed interventions should be offered.
Institutional Care and Family Reintegration: The Transition Process in the Voices of Young Brazilians
Authors: D’Aroz Marlene Schüssler
Published: January 2022

This article aims to present reflections on the transition from being institutionalised to autonomous life, from the perspective of deinstitutionalised young Brazilians. Five young adults participated in the pilot study. The Piagetian clinical method was used. Through semi-structured interviews, the following were investigated: causes of institutionalisation, preparation for transition, deinstitutionalisation and perspectives of present and future life. The results indicate that there was no effective preparation for transition from the institution to the family and/or independent life. Biological families have difficulties in achieving (re) integration and overcoming conflicts between parents and children. In conclusion, when leaving institutions, some young people manage to build their own arrangements for a new life trajectory, while others return to contexts of risk and life on the street. Public policies to assist these young people should be prioritised.
Wave propagation and directionality in two-dimensional periodic lattices considering shear deformations
Authors: Sepehri Soroush , Mosavi Mashhadi Mahmoud , Seyyed Fakhrabadi Mir Masoud
Published: January 2022

The effects of shear deformation on analysis of the wave propagation in periodic lattices are often assumed negligible. However, this assumption is not always true, especially for the lattices made of beams with smaller aspect ratios. Therefore, in the present paper, the effect of shear deformation on wave propagation in periodic lattices with different topologies is studied and their wave attenuation and directionality performances are compared. Current experimental limitations make the researchers focus more on the wave propagation in the direction perpendicular to the plane of periodicity in micro/nanoscale lattice materials while for their macro/mesoscale counterparts, in-plane modes can also be analyzed as well as the out-of-plane ones. Four well-known topologies of hexagonal, triangular, square, and Kagomé are considered in the current paper and their wave propagation is investigated both in the plane of periodicity and in the out-of-plane direction. The finite element method is used to formulate the governing equations and Bloch’s theorem is used to solve the dispersion relations. To investigate the effect of shear deformation, both the Timoshenko and Euler-Bernoulli beam theories are implemented. The results indicate that including shear deformation in wave propagation has a softening effect on the band diagrams of wave propagation and moves the dispersion branches to lower frequencies. It can also reveal some bandgaps that are not predicted without considering the shear deformation.
Prisoner releases in postcolonial Uganda: Power, politics, and the public
Authors: Bruce-Lockhart Katherine
Published: January 2022

This article examines prisoner releases in postcolonial Uganda, focusing on the period between independence in 1962 and the inauguration of Yoweri Museveni in 1986. During these decades, Uganda's government enacted over 30 large scale releases of prisoners and detainees, affecting approximately 20,000 individuals. These acts of clemency were highly politicized and frequently occurred during times of political transition or tension. While framed by Uganda's leaders and the official media as gestures of goodwill and symbols of progress, these releases ultimately reinforced executive power and the centrality of incarceration in state repression.
Inflammasome activation in neutrophils of patients with severe COVID-19
Authors: Aymonnier Karen , Ng Julie , Fredenburgh Laura E. , Zambrano-Vera Katherin , Münzer Patrick , Gutch Sarah , Fukui Shoichi , Desjardins Michael , Subramaniam Meera , Baron Rebecca M , Raby Benjamin A. , Perrella Mark A. , Lederer James A. , Wagner Denisa D.
Published: January 2022

Infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) engages the inflammasome in monocytes and macrophages and leads to the cytokine storm in COVID-19. Neutrophils, the most abundant leukocytes, release neutrophil extracellular traps (NETs), which have been implicated in the pathogenesis of COVID-19. Our recent study shows that activation of the NLRP3 inflammasome is important for NET release in sterile inflammation. However, the role of neutrophil inflammasome formation in human disease is unknown. We hypothesized that SARS-CoV-2 infection may induce inflammasome activation in neutrophils. We also aimed to assess the localization of inflammasome formation (ie, apoptosis-associated speck-like protein containing a CARD [ASC] speck assembly) and timing relative to NETosis in stimulated neutrophils by real-time video microscopy. Neutrophils isolated from severe COVID-19 patients demonstrated that ∼2% of neutrophils in both the peripheral blood and tracheal aspirates presented ASC speck. ASC speck was observed in neutrophils with an intact poly-lobulated nucleus, suggesting early formation during neutrophil activation. Additionally, 40% of nuclei were positive for citrullinated histone H3, and there was a significant correlation between speck formation and nuclear histone citrullination. Time-lapse microscopy in lipopolysaccharide -stimulated neutrophils from fluorescent ASC reporter mice showed that ASC speck formed transiently and at the microtubule organizing center long before NET release. Our study shows that ASC speck is present in neutrophils from COVID-19 patients with respiratory failure and that it forms early in NETosis. Our findings suggest that inhibition of neutrophil inflammasomes may be beneficial in COVID-19.
Novel volumetric capnography indices measure ventilation inhomogeneity in cystic fibrosis
Authors: Fouzas Sotirios , Kentgens Anne-Christianne , Lagiou Olga , Frauchiger Bettina Sarah , Wyler Florian , Theodorakopoulos Ilias , Yammine Sophie , Latzin Philipp
Published: January 2022

Background

Volumetric capnography (VCap) is a simpler alternative to multiple-breath washout (MBW) to detect ventilation inhomogeneity in patients with cystic fibrosis (CF). However, its diagnostic performance is influenced by breathing dynamics. We introduce two novel VCap indices, the capnographic inhomogeneity indices (CIIs), that may overcome this limitation and explore their diagnostic characteristics in a cohort of CF patients.

Methods

We analysed 320 N2-MBW trials from 50 CF patients and 65 controls (age 4–18 years) and calculated classical VCap indices, such as slope III (SIII) and the capnographic index (KPIv). We introduced novel CIIs based on a theoretical lung model and assessed their diagnostic performance compared to classical VCap indices and the lung clearance index (LCI).

Results

Both CIIs were significantly higher in CF patients compared with controls (mean±sdCII15.9±1.4%versus5.1±1.0%, p=0.002; CII27.7±1.8%versus6.8±1.4%, p=0.002) and presented strong correlation with LCI (CII1r2=0.47 and CII2r2=0.44 in CF patients). Classical VCap indices showed inferior discriminative ability (SIII 2.3±1.0%/Lversus1.9±0.7%/L, p=0.013; KPIv 3.9±1.3%versus3.5±1.2%, p=0.071), while the correlation with LCI was weak (SIII r2=0.03; KPIv r2=0.08 in CF patients). CIIs showed lower intra-subject inter-trial variability, calculated as coefficient of variation for three and relative difference for two trials, than classical VCap indices, but higher than LCI (CII111.1±8.2% and CII211.0±8.0%versusSIII 16.3±13.5%; KPIv 15.9±12.8%; LCI 5.9%±4.2%).

Conclusion

CIIs detect ventilation inhomogeneity better than classical VCap indices and correlate well with LCI. However, further studies on their diagnostic performance and clinical utility are required.
Assessment of peripheral biomarkers potentially involved in episodic and chronic migraine: a case-control study with a focus on NGF, BDNF, VEGF, and PGE2
Authors: Mozafarihashjin Mohammad , Togha Mansoureh , Ghorbani Zeinab , Farbod Abolfazl , Rafiee Pegah , Martami Fahimeh
Published: January 2022

Background

Several inflammatory and vascular molecules, and neurotrophins have been suggested to have a possible role in the development of migraine. However, pathophysiological events leading to migraine onset and transformation of episodic migraine (EM) to chronic migraine (CM) are not fully understood. Thus, we aimed to assess peripheral levels of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), and prostaglandin E2 (PGE2) in EM and CM patients, and controls.

Methods

From September 2017 to June 2020, 89 subjects were enrolled in a case-control study; 23 and 36 EM and CM patients, respectively, and 30 age and sex-matched controls. Demographic data and medical history were obtained from all patients. Headache characteristics were recorded at baseline visit and ensuing 30 days for persons with migraine disease. Serum levels of NGF, BDNF, VEGF, and PGE2 were measured once for controls and EM and CM patients, and adjusted for age, sex, and body mass index.

Results

Serum levels of NGF were significantly lower in EM patients compared to controls and CM patients (P-value=0.003 and 0.042, respectively). Serum levels of BDNF were significantly lower in EM and CM patients as opposed to controls (P-value<0.001), but comparable between EM and CM patients (P-value=0.715). Peripheral blood levels of VEGF were significantly higher in EM and CM patients as opposed to controls (P-value<0.001), but not different between EM and CM patients (P-value=0.859). Serum levels of PGE2 were significantly lower in EM patients compared to controls (P-value=0.011), however similar between EM and CM patients (P-value=0.086). In migraine patients, serum levels of NGF and PGE2 positively correlated with headache frequency (NGF: ρ = 0.476 and P-value<0.001; PGE2: ρ = 0.286 and P-value=0.028), while corresponding levels of BDNF and VEGF did not correlate with headache frequency (BDNF: ρ = 0.037 and P-value=0.778; VEGF: ρ= -0.025 and P-value=0.850).

Conclusions

Our findings suggest that NGF, BDNF, PGE2, and VEGF may play a significant role in migraine pathogenesis and/or chronification, and therefore might bear potential value for novel targeted abortive and prophylactic migraine therapy. Further prospective cohort studies with larger sample sizes can more robustly evaluate the implications of these findings.
Specificity of H2O2 signaling in leaf senescence: is the ratio of H2O2 contents in different cellular compartments sensed in Arabidopsis plants?
Authors: Zentgraf Ulrike , Andrade-Galan Ana Gabriela , Bieker Stefan
Published: January 2022

Leaf senescence is an integral part of plant development and is driven by endogenous cues such as leaf or plant age. Developmental senescence aims to maximize the usage of carbon, nitrogen and mineral resources for growth and/or for the sake of the next generation. This requires efficient reallocation of the resources out of the senescing tissue into developing parts of the plant such as new leaves, fruits and seeds. However, premature senescence can be induced by severe and long-lasting biotic or abiotic stress conditions. It serves as an exit strategy to guarantee offspring in an unfavorable environment but is often combined with a trade-off in seed number and quality. In order to coordinate the very complex process of developmental senescence with environmental signals, highly organized networks and regulatory cues have to be in place. Reactive oxygen species, especially hydrogen peroxide (H2O2), are involved in senescence as well as in stress signaling. Here, we want to summarize the role of H2O2 as a signaling molecule in leaf senescence and shed more light on how specificity in signaling might be achieved. Altered hydrogen peroxide contents in specific compartments revealed a differential impact of H2O2 produced in different compartments. Arabidopsis lines with lower H2O2 levels in chloroplasts and cytoplasm point to the possibility that not the actual contents but the ratio between the two different compartments is sensed by the plant cells.
High-Hole-Mobility Metal–Organic Framework as Dopant-Free Hole Transport Layer for Perovskite Solar Cells
Authors: Wang Ruonan , Yu Weikang , Sun Cheng , Chiranjeevulu Kashi , Deng Shuguang , Wu Jiang , Yan Feng , Peng Changsi , Lou Yanhui , Xu Gang , Zou Guifu
Published: January 2022

A dopant-free hole transport layer with high mobility and a low-temperature process is desired for optoelectronic devices. Here, we study a metal–organic framework material with high hole mobility and strong hole extraction capability as an ideal hole transport layer for perovskite solar cells. By utilizing lifting-up method, the thickness controllable floating film of Ni3(2,3,6,7,10,11-hexaiminotriphenylene)2 at the gas–liquid interface is transferred onto ITO-coated glass substrate. The Ni3(2,3,6,7,10,11-hexaiminotriphenylene)2 film demonstrates high compactness and uniformity. The root-mean-square roughness of the film is 5.5 nm. The ultraviolet photoelectron spectroscopy and the steady-state photoluminescence spectra exhibit the Ni3(HITP)2 film can effectively transfer holes from perovskite film to anode. The perovskite solar cells based on Ni3(HITP)2 as a dopant-free hole transport layer achieve a champion power conversion efficiency of 10.3%. This work broadens the application of metal–organic frameworks in the field of perovskite solar cells.

Graphical Abstract
Transfer Printing of Perovskite Whispering Gallery Mode Laser Cavities by Thermal Release Tape
Authors: Li Guo-Hui , Zhou Bo-Lin , Hou Zhen , Wei Yan-Fu , Wen Rong , Ji Ting , Wei Yi , Hao Yu-Ying , Cui Yan-Xia
Published: January 2022

The outstanding optoelectrical properties and high-quality factor of whispering gallery mode perovskite nanocavities make it attractive for applications in small lasers. However, efforts to make lasers with better performance have been hampered by the lack of efficient methods for the synthesis and transfer of perovskite nanocavities on desired substrate at quality required for applications. Here, we report transfer printing of perovskite nanocavities grown by chemical vapor deposition from mica substrate onto SiO2 substrate. Transferred perovskite nanocavity has an RMS roughness of ~ 1.2 nm and no thermal degradation in thermal release process. We further use femtosecond laser to excite a transferred perovskite nanocavity and measures its quality factor as high as 2580 and a lasing threshold of 27.89 μJ/cm2 which is almost unchanged as compared with pristine perovskite nanocavities. This method represents a significant step toward the realization of perovskite nanolasers with smaller sizes and better heat management as well as application in optoelectronic devices.
Ultra-High Response Detection of Alcohols Based on CdS/MoS2 Composite
Authors: Liu Lei , Yang Weiye , Zhang Hui , Yan Xueqian , Liu Yingkai
Published: January 2022

Hybrid CdS/MoS2 with branch and leaf shaped structures are successfully synthesized by hydrothermal method. It is applied to detect volatile organic compounds, a basic source of indoor air pollution with deleterious effects on the human health. The sensor based on CdS/MoS2 displays an outstanding response to alcohols among numerous gases. Their response to 100 ppm ethanol and isopropanol reaches 56 and 94, respectively. Benefiting from the dendrite-like biomimetic structure and synergy effect of CdS and MoS2, the sensor exhibits higher response than traditional gas sensor. For multiple alcohols, the limit of detection reached ppb level. In addition, by comparing the response of ethanol, isopropanol, isoamyl alcohol and their mixtures with acetone and methanal, a strong resistance interference is observed. This work proved that the modified detector holds broad promise in the detection of alcohols.
Uncomplicated Plasmodium vivax malaria: mapping the proteome from circulating platelets
Authors: Fernández Diana , Segura Cesar , Arman Mònica , McGill Suzanne , Burchmore Richard , Lopera-Mesa Tatiana
Published: January 2022

Background

Thrombocytopenia is frequent in Plasmodium vivax malaria but the role of platelets in pathogenesis is unknown. Our study explores the platelet (PLT) proteome from uncomplicated P. vivax patients, to fingerprint molecular pathways related to platelet function. Plasma levels of Platelet factor 4 (PF4/CXCL4) and Von Willebrand factor (VWf), as well as in vitro PLTs—P. vivax infected erythrocytes (Pv-IEs) interactions were also evaluated to explore the PLT response and effect on parasite development.

Methods

A cohort of 48 patients and 25 healthy controls were enrolled. PLTs were purified from 5 patients and 5 healthy controls for Liquid Chromatography–Mass spectrometry (LC–MS/MS) analysis. Plasma levels of PF4/CXCL4 and VWf were measured in all participants. Additionally, P. vivax isolates (n = 10) were co-cultured with PLTs to measure PLT activation by PF4/CXCL4 and Pv-IE schizonts formation by light microscopy.

Results

The proteome from uncomplicated P. vivax patients showed 26 out of 215 proteins significantly decreased. PF4/CXCL4 was significantly decreased followed by other proteins involved in platelet activation, cytoskeletal remodeling, and endothelial adhesion, including glycoprotein V that was significantly decreased in thrombocytopenic patients. In contrast, acute phase proteins, including SERPINs and Amyloid Serum A1 were increased. High levels of VWf in plasma from patients suggested endothelial activation while PF4/CXCL4 plasma levels were similar between patients and controls. Interestingly, high levels of PF4/CXCL4 were released from PLTs—Pv-IEs co-cultures while Pv-IEs schizont formation was inhibited.

Conclusions

The PLT proteome analyzed in this study suggests that PLTs actively respond to P. vivax infection. Altogether, our findings suggest important roles of PF4/CXCL4 during uncomplicated P. vivax infection through a possible intracellular localization. Our study shows that platelets are active responders to P. vivax infection, inhibiting intraerythrocytic parasite development. Future studies are needed to further investigate the molecular pathways of interaction between platelet proteins found in this study and host response, which could affect parasite control as well as disease progression.