bluuebunny/crossref_metadata_2025 huggingface dataset:
Screening of Punica granatum extract for antimicrobial activity against oral micro organisms
Authors:   MDS (Periodontics), Owner of ANAGHA DENTAL CARE Clinic, Warangal, Telangana State, India, Avadhani Meera , Kukkamalla Meena Anand ,   Professor, Department of Periodontics, Melaka Manipal College of Dental Sciences, Malaysia, Bhat Kishore G ,   Professor and Head, Department of Microbiology and immunology, Maratha Mandal Institute of Research Centre, Belgaum, Karnataka State, India
Published: September 2021

Background and Objectives: A lot of research work in both dental and medical fields support the curative properties of pomegranate. Accordingly, it was decided to prepare a pomegranate mouthwash and evaluate it among Dental patients diagnosed with Chronic Gingivitis. The objective of the present invitro study is to assess the Minimum Inhibitory Concentration (MIC) of the commercially available pomegranate extract powder against few oral pathogenic microorganisms. Methodology: Serial dilution method using thioglycolate broth medium was used for anerobes like Streptococcus mutans, Fusobacterium nucleatum, Aggregatibacter actinomycetomcomitans, Prevotella intermedia and Mueller hinton agar mediated growth was used for aerobe like Staphylococcus aureus. Following which microdilution assay was performed and accordingly evaluated the MIC. Based on this report, the test rinse was prepared and further evaluated using the same methodology for both aerobes and anerobes. Results and Inference: It was observed from the MIC report for both aerobes and anerobes that at a concentration of 0.2% the formulated mouth rinse was effective against all the chosen organisms. The results of the study infer that products like mouthwash, dental gels etc made from this concentration could be possibly used for the control of dental infections.
Pharmaceutical and Analytical Standardization of “Medopachak Vati”
Authors:   Associate Professor, Department of Rasashastra and Bhaishajya Kalpana, Seth Chandanmal Mutha Aryangla Ayurved Mahavidyalaya, Satara, Maharashtra, India, Joshi Sayali Joglekar , Deshpande Sarang ,   Vice Principal and HOD, Dept of Rasashastra and Bhaishajya Kalpana, Vijayashree Ayurvedic medical college and Hospital, Jabalpur, M.P., India
Published: September 2021

In ancient Ayurvedic classics, many formulations are there like herbal, mineral and herbomineral in origin. These formulations are effective in many diseases depending upon their qualities and properties. In this study, we are dealing with medopachak vati which is herbal preparation. In Charak Samhita, Uttarsthana, Aacharya Charak mentioned Pachak Yoga in the treatment of Vishamjwara. “Medopachak yoga” which is useful in the Treatment of Medogatjwar. Many of the Ayurvedic paractitioners prescribe Medopachak yoga in various dosage forms like kashaya (Decoction), Churna (Powder) as per their convenience. Dosage form for administration plays an important role in the reaction and delivery of particular drug on a specific system. Tablets are easy to prepare, packing, transportation and administration to patients. Hence tablet form is the most accepted dosage form amongst all. In this study, formulation of “Medopachak Yoga” is transformed to the tablet form by using modern equipments and analytical techniques. An effort is made to validate the pharmaceutical and analytical procedures to maintain the quality of product and to avoid batch to batch variation. Pharmacopeial standards are set for this Ayurvedic formulation in tablet form. All the 3 samples were prepared by this method show identical characteristics and analytical parameters do not show much significant difference. These set parameters may be used for the further pharmaceutical preparations.
Bauhinia purpurea: An Updated Pharmacological Profile
Authors:   Assistant Professor, Pharmacognosy and Phytochemistry Department, Gurunanak College of Pharmacy, Nari, Nagpur- 440 026, Maharashtra, India, SumitKArora  , MaviyaHussain  ,   B. Pharm final year (Student), Gurunanak College of Pharmacy, Nari, Nagpur- 440 026, Maharashtra, India, SubhashRYende  ,   Assistant Professor, Pharmacology Department, Gurunanak College of Pharmacy, Nari, Nagpur- 440 026, Maharashtra, India, KeshavMoharir  ,   Assistant Professor, Pharmaceutics Department, Gurunanak College of Pharmacy, Nari, Nagpur- 440 026, Maharashtra, India, Pande Vipinchandra ,   Assistant Professor, Pharmacology Department, Gurunanak College of Pharmacy, Nari, Nagpur- 440 026, Maharashtra, India, Ittadwar Abhay ,   Principal, Pharmacognosy and Phytochemistry Department, Gurunanak College of Pharmacy, Nari, Nagpur- 440 026, Maharashtra, India
Published: September 2021

Bauhinia purpurea (B. purpurea) (family: Fabaceae) commonly called as butter fly tree has vast medicinal uses and remarkable pharmacological potential. Various phytoconstituents, extracts and parts of this plant were possess significant pharmacological activities such as cardiac activity, antifungal, wound healing, antidiabetic, antiulcer, antioxidant, antinociceptive, hepatoprotective, nephroprotective, antidiarrhoeal, anti-inflammatory, antipyretic, analgesic, antimalarial, gastro protective and cytoprotective activity. The present study emphasizes the overview of recent studies and/or updates on pharmacological potential of B. purpurea.
Ayurveda Management of Pittaj Mukhapak (Aphthous ulcer): A Case Study
Authors:   Associate Professor, Departments of Panchakarma, RK University Ayurved College and Hospital Bhavnagar Highway, Rajkot, Gujarat, India, Ghaywate Ravindra B. , Ghuge Pallavi M. ,   MD (Scholar), Department of Samhita, Bhau Saheb Mulak Ayurved College, Nandanvan, Nagpur, Maharashtra, India, Suryavanshi Ravikumar S. ,   Associate Professor, Departments of Shalyatantra, RK University Ayurved College and Hospital Bhavnagar Express Highway Rajkot, Gujarat, India, Lanje Sandip ,   Associate Professor, Department of Sharir Rachana, Shree Balahanuman Ayurved Mahavidyalaya, At & Po. Lodhra. Tal. Mansa Dist. Gandhinagar, Gujarat, India
Published: September 2021

Oral hygiene is very important for Health. Tongue is the mirror of GIT (Gastrointestinal Tract). Mukhapak (Stomatitis) i: e the inflammation of Mucous membrane present in lips, tongue and cheek. It is common problems faced by all persons. Though it looks minor problem but it restricted the daily activity. Stomatitis occurs due to hot and spicy, oily food, Smoking, tobacco, Gutkha chewing, Some Medicine, infection, Vitamin B-Complex deficiency. Ayurveda has described 4 type of Mukhapaka. Vataj, Pittaj, Kaphaj, Sannipataj. Different types of Mukhapak have different type of symptoms. The treatment of Aphthous ulcer/Stomatitis mainly pain reliever, mouth lotion, Corticosteroids, Vit.B complex. Present case study of 26 year male Patients having symptoms of Toda (Pricking Pain), Daha (Burning), Aasyvairasya (Diminish Taste of food), Constipation, Difficult to engulfed food, Chittodweg (Anxious). Diagnosis done as a Pittaj Mukhapak, undergo the Ayurveda treatment as Gandush Vidhi and Shaman treatment for 7 days. After 7 day Patients was much relieved. Present Case Study Was done to Study the concept of Pittaj Mukhpak (Apthous Ulcer) in Ayurveda View, to study the effect of Ayurveda treatment on Symptoms, To Study Effect of Gandush Vidhi and Shaman treatment in Pittaj Mukhpak.
Pharmacognostic review of Astercantha longifolia (L.) Nees, & its possible use in prevention of COVID-19
Authors:   MD(Ayu), Assistant Professor, Department of Dravyaguna, SSN Ayu College & RI, Paikmal, Odisha, India, Mohanty Shiva Prasad , Rautaray Kshirabdhi Tanaya ,   MD(Ayu), Professor, Department of Samhita, SSN Ayu College & RI, Paikmal, Odisha, India
Published: September 2021

Astercantha longifolia is an annual herb from Acanthaceae family found almost as weed throughout plainlands, all over India. It is very much important from Ayurveda point of view for its curative role in many disease conditions. It is called as Kokilakshya in Ayurveda & Talamakhanna in Unani system. Its importance in Ayurveda can be judged by its visibility in Samhitas & Nighantus. India is a young country with billion plus population & having second highest in COVID affected numbers. Being a viral disease, immunity boosting drugs are the need of the hour & Astercantha longifolia (L) Nees or Kokilakshya fits in this situation perfectly. It has many pharmacological activities and the best action is, its free radical scavenging activity. Viral infections unleash storms of cytokinin, which produces abundant free radicals & the complications of COVID 19 are mainly due to these free radicals [1] . So, keeping all these qualities in mind, an honest attempt is made to enumerate those details and justify its perspective utility in Covid 19.
The Successful Treatment of Bullous Pemphigoid by Herbal Therapeutic: A case report
Authors:   Department of Tropical Agriculture and international Cooperation, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan, Ung Le Quang ,   Herbal Medicine Laboratory, Thai Nguyen University of Agriculture and Forestry, Thai Nguyen, Vietnam, Liang Lay Horng ,   Herbal Chinese Medicine Laboratory, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan, Lanh Thi-Ngoc ,   Department of Basic Science, Thai Nguyen University of Agriculture and Forestry, Thái Nguyên, Vietnam, Thi-Thu Le  ,   Thai Nguyen College of Economics and Techniques, Tan Thinh Ward, Thai Nguyen City, Vietnam
Published: September 2021

A case of a patient who is diagnosed with bullous pemphigoid was successfully treated by traditional medicine therapy after attempted to taking pharmaceutical drugs more three months but more serious disease level. The authors recommend that using herbal medicine for treatment of bullous pemphigoid is potent and that thorough scientific scrutiny is necessary in future researches.
Traditional Approach to Cure Shingles Using Medicinal Plants in Eastern Nepal
Authors:   Department of Botany, Mechi Multiple Campus (Tribhuvan University), Bhadrapur, Jhapa, Nepal., Khatiwada Homnath , Neupane Ajay ,   Department of Botany, Mechi Multiple Campus (Tribhuvan University), Bhadrapur, Jhapa, Nepal., Thapa Lal B ,   Central Department of Botany, Institute of Science and Technology, Tribhuvan University, Kirtipur, Kathmandu, Nepal
Published: September 2021

Oral Collection and documentation of indigenous knowledge of local people have an important role in scientific research, biodiversity conservation, and the drug development process. A study was carried out to document the medicinal plants that have been used by the local folk healer to treat Shingles in Ilam district, Eastern Nepal. A renowned folk healer who was involved in curing Shingles for decades and 30 key informants were selected for the interview to know the methods of curing Shingles. Altogether six plants viz: Oroxylum indicum, Cynodon dactylon, Centella asiatica, Drymaria cordata, Sesamum indicum, and Lygodium japonicum were found to be used against the disease. The traditional method of preparing medicine from these plants was found to be highly effective. The finding provides a clue for further extensive lab-based research to isolate the specific compounds that are effective against the disease.
Adulteration & Substitution: An Interrupted and Noninterrupted Practices in Medicinal Plants in Ambiguous Herbal World
Authors:   Associate Professor, Department of Biosciences, Veer Narmad South Gujarat University, Surat-395007, India, Farzin Parabia , Miral Ladani ,   Research Student, Ashok & Rita Patel Institute of Intigrated Biotechnology and Allied Sciences, New Vallabh Vidyanagar- 388120, India
Published: September 2021

In India approximately 80% tribal population depends on herbal medicines for their health and proper care to cure disease at first primary level. Generally, these herbal medicines are classified into five different classes. Now a days people are not more worried about Ayurvedic medicines therefore Ayurvedic practitioners become busy professionals like other modern practitioners because preparation of their own medicines requires so much time and its processing is hard enough for patients as well as their family members also. Substitution of Ayurvedic medicines is carried out therefore is carried out Ayurvedic medicines are facings number of problems for different purposes. Ambiguous medicinal plants are those plants which are described very well in classes of Ayurvedic ancient medicines in a well manner but their identification is not yet clear. Based on book related survey these plants are identified and defined by many names. Sometimes one common name is given to two or more than two medicinalplants.Substitution and aduteration are activities that are most often seen in herbal businesses. Aim of th ese practices is mainly found in many large or small commercial firms include Worst mixing with other plant raw m aterials, substitution,addition with great skill, loss of medicinal properties of main drug. Now a day's substitution a nd adulteration is extremely important step in herbal businesses. Therefore there is need for proper methods for their right medicinal plants and herbal medicines.
EVALUASI KETERPENGARUHAN KOMPONEN PERIWISATA DI DAYA TARIK PARIWISATA ARUNG JERAM PAPUALANGI
Authors: Dai Srilian Laxmiwaty , Mamonto Deswita Natarisa
Published: September 2021

Dalam penelitian tentang Evaluasi Keterpengaruhan Komponen Pariwisata Didaya Tarik Pariwisata Arung Jeram Papualangi penulis menggunakan pendekatan kualitatif dimana penelitian yang dilakukan bersifat deskriptif yaitu memberikan gambaran ataupun penjelasan yang tepat mengenai permasalahan yang dihadapi dan didukung dengan data primer dan data sekunder. Teknik pengumpulan data yang digunakan adalah wawancara dan observasi. Dari hasil penelitian menunjukkan bahwa pada pelaksanaan Evaluasi Keterpengaruhan Komponen Pariwisata Didaya Tarik Pariwisata Arung Jeram Papualangi telah berjalan sesuai dengan sistem yang ada, namun terdapat masalah-masalah yang membawa dampak negatif sehingga pada pelaksanaannya masih belum optimal dalam mengembangkan pariwisata Tana Toraja, khususnya pembangunan infrastruktur, sarana dan prasana. Faktor yang mempengaruhi perkembangan pariwisata adalah faktor pendukung yaitu objek wisata yang sudah terkenal, partisipasi masyarakat dan koordinasi yang baik dengan pihak terkait. Sedangkan faktor penghambat yaitu keterbatasan dana, lokasi geografis objek wisata serta minimnya dan tidak terpusatnya informasi.
Potensi Wisata Curung Indah Tegalrejo Gunung Kidul Yogyakarta dengan Pendekatan Analisis SWOT
Authors: Lagalo Anggraeni M.S
Published: September 2021

Beberapa kecenderungan tentang peningkatan SDM ini sangatlah jelas terlihat oleh beberapa tempat wisata yang terkenal di Indonesia, sebut saja wilayah-wilayah yang banyak di kenal sebagai objek wisata di Indonesia adalah wilayah Bali, Lombok, Yogyakarta, Bandung, Papua, dll. Tujuan Penelitian ini adalah mendeskripsikan potensi wisata Curung Indah Tegalrejo Gunung Kidul Yogyakarta dengan Pendekatan Analisis SWOT dengan jenis penelitian kualitatif deskriptif. Hasil penelitian menunjukkan bahwa tidak ada hal lain dalam memajukan suatu objek wisata selain dengan ketujuh sapta pesona tersebut, dalam hal ini: aman, tertib, bersih, indah, sejuk, ramah tamah, dan kenangan merupakan suatu kesatuan yang saling terkait dalam dunia pariwisata. Jadi, untuk kemajuannya dibutuhkan tenaga profesional yang merupakan bagian dari masyarakat dan pemerintah guna mendorong terus berkembangnya objek wisata dalam suatu daerah yang ada di Indonesia ini.
FAKTOR EKSTERNAL DAN INTERNAL PENGELOLAAN DESTINASI WISATA BERKELANJUTAN DI DESA WISATA MALANGAN YOGYAKARTA
Authors: Hatibie Irma Kharisma , Purwaningrum Hesti
Published: September 2021

The rural tourist attraction of Malangan, Sumberayu Moyudan, is one of the tourist rural destination in the Yogyakarta Regency which is also affected by the rampant development of rural-based tourism products. Although this tourist village has received special interest from tourists, it does not mean that every tourist village can survive and present tourism products that can continue to attract tourists to come. In that case, strategic action is needed in destination destinations, such as observations, observing all aspects related to destination sustainability. This is due to the increasing number of tourist villages in an area, there will be many competitors or competitors, as a result, there will be fierce competition or even unhealthy competition between tourism village managers. This research was conducted to answer the challenge of the importance of management that is right on target at the destination, while still paying attention to the principles of the existence of a tourist village built using a SWOT analysis. The result of this research is to present a destination management strategy based on an analysis of external and internal factors, which includes the strengths, weaknesses, opportunities, and threats of each category.
Nanotubes and other allotropic carbon forms by chemical vapor deposition on an inconel surface
Authors: Pérez-Bustamante F. , Avalos-Belmontes F. , Ramos-Cano F. , Pérez-Bustamante R.
Published: September 2021

Allotropic carbon forms such as fullerenes, nanotubes and graphenes, have received a notable attention by the scientific community due to their unique configuration and interesting chemical and physical properties. In this respect, in this work, carbon nanotubes were synthesized through chemical vapour deposition. The reaction was carried out in tubular furnace by the catalytic reaction of ferrocene/ethanol solution onto an Inconel 600 surface and by the variation on the synthesis conditions for their production. The presence of double- and few-walled nanotubes grown in bundle arrays was observed. However, additionally, the presence of other carbon structures such as graphenes, graphitic onions and graphene nanoribbons were observed through electronic microscopy.
O cinema-poesia de Cláudio Assis
Authors: De Holanda Raquel , De Castro Gustavo
Published: September 2021

O presente artigo propõe uma discussão acerca da produção audiovisual de Cláudio Assis. Buscamos em Assis poemas na forma de imagens cinematográficas, a partir da noção genérica de “razão-poesia” (Castro & Dravet, 2015). Esta forma de entender as imagens nos leva a uma questão que nos parece acerca do papel do espaço nas construções visuais do cineasta, que é a de compreender as imagens cinematográficas como criações poéticas e espaços de flutuação e de intermitência do sensível.
Betel Quid, Smoking and Alcohol Dependency among Patients with Oral Potentially Malignant Disorders and Oral Cancer in Sri Lanka; A Preliminary Case-control Study
Authors: R. Sumithrarachchi Sumali , Pemasiri W.A.Udari.C. , Pathiranage A.M.S. Deepanie. , Jayasooriya Primali R.
Published: September 2021

Introduction: Oral cancer and Oral Potentially Malignant Disorders (OPMDs) arising due to risk habits like betel quid (BQ) chewing, smoking and alcohol use are preventable despite the high prevalence and poor survival rates. However, dependence to risk habits has become a barrier to prevent OPMDs and oral cancer. Objectives: This study was conducted to determine the dependence to risk habits among patients with such oral lesions, and the quitting among dependent users after diagnosis. Materials and method: A case-control study was conducted among 100 participants, 50 diagnosed with OPMDs and oral cancer from two Oral and Maxillo Facial clinics in Sri Lanka and a similar control group without any oral lesions. All participants practiced one or more risk habits such as BQ chewing, smoking and/or alcohol use. Dependence was assessed using Sinhala language translations of standardized scales such as Betel Quid Dependence Scale for BQ chewers, Fagerstrom Test for Nicotine Dependence for tobacco smokers and CAGE (“Cut down”, “Annoyed”, “Guilty” and “Eye opener”) scale for alcohol users. Results: Dependence on habits was more among the case group (BQ-93%; smoking-14%; alcohol-66%). Quitting rates of BQ and alcohol among those who were diagnosed with oral cancer [BQ (89%), alcohol (89%)] were higher (p<0.05) than those with OPMDs [BQ (50%), alcohol (22%)]. Lack of awareness due to low socio-economic status (97%) was a significant association for BQ dependence (p=0.01).Conclusion: In conclusion, development of OPMDs and oral cancer increases with dependence to BQ chewing, smoking and alcohol use. Increased awareness about OPMDs and its risk of malignancy is needed among public. Prevention of dependence to these risk habits also becomes essential.
MDM2 (T309G) Gene Polymorphism Determines the Susceptibility of Hepatocellular Carcinoma in Bangladesh
Authors: Hosen Md. Bayejid , Khaleque Narwana , Chakraborty Sajib , Mahtab Mamun Al , Kabir Yearul
Published: September 2021

Background: Hepatocellular carcinoma (HCC) is one of the fatal cancer types worldwide, and a variety of genetic factors are considered to be associated with this incidence. MDM2 gene plays a pivotal role in various pathways, which are essential to combat tumor formation. The study aimed to find out the associations of MDM2 (T309G, rs2279744) gene polymorphism with the development of HCC in the Bangladeshi population. Methods: A case-control study on 100 HCC patients and 110 control subjects was conducted. The genotyping of the MDM2 (T309G) gene was done using PCR-RFLP methods. Results: The percentage of TT and GG genotypes were significantly different (p<0.01) among the study subjects. There were four genotyping groups, while the subjects with TT genotypes were considered the reference group. Patients with GG genotypes were at high risk of developing HCC (OR, 3.6; 95 % CI, 1.64–7.80; p<0.01) compared to the control. On the other hand, the association of TG genotypes with HCC was not statistically significant (OR, 1.8; 95 % CI, 0.91–3.40, p>0.05). In addition, patients having either GG or TG genotypes showed higher risk for HCC compared to control group (OR = 2.20; 95% CI = 1.21–4.14; P < 0.05). Conclusion: Our study suggested that the MDM2 gene may have a strong association with the development of HCC, and the GG allele could serve as an essential determinant to identify the higher risk of HCC in the Bangladeshi population.
Screening Practices among First Degree Relatives of Breast Cancer Patients in Nepal: A Cross-sectional Study
Authors: Mulmi Rashmi , Shrestha Gambhir , Niraula Surya Raj , Yadav Deepak Kumar , Pokharel Paras Kumar
Published: September 2021

Objective: Family history is a significant risk factor for development of breast cancer, particularly for women of first-degree relatives. For women at high risk for breast cancer, regular screening is the mainstay of risk management. This study aims to find out the breast cancer screening practices among first degree relatives of breast cancer patient. Methods: A cross-sectional study was carried out among 150 purposively selected first-degree female relatives of breast cancer patients undergoing treatment at B.P Koirala Memorial Cancer Hospital, aged between 20 and 60 years. A semi-structured questionnaire was used to collect data by face to face interview, which included socio-demographic characteristics, personal history, awareness on breast cancer and screening practices. Results: The mean age of the participants was 37.6 years (SD 10.9). A total of 116 (77.3%) women had ever practiced breast self-examination (regular=34.7%; irregular= 42.7%) and 42 (28.0%) had ever practiced clinical breast examination (regular=14.7%; irregular=13.3%). Only 10 percent of the women had performed mammogram regularly. Only two-fifth of them had a high level of awareness on risk factors and warning signs of breast cancer. Conclusions: This study showed a low rate of regular screening practices among the first degree relatives of breast cancer patients. There is a need to provide comprehensive, and inclusive information and support and interventions aimed at increasing awareness of the importance of healthy behaviors in cancer prevention among these high-risk groups.
Characteristic of the vasorlaxant action of the talatisamine alkaloid and its derivatives
Authors: Yu.T. Mirzayeva
Published: September 2021

The aim of our research is to study the effect relaxant action of diterpenoid alkaloids talatisamine, 14-O-benzoylthalatisamine and 14-O-acetylthalatisamine was studied using isolated rat aortic rings. Alkaloids significantly and dose-dependently inhibited contraction of the aortic rings caused by high KCl content. At the same time, under these conditions, alkaloids significantly reduced Ca2+-induced contraction of the aortic rings. The relaxing effects of alkaloids are significantly suppressed by verapamil, a potent potentiometer-dependent Ca2+ channel blocker. The alkaloids also significantly reduced norepinephrine-induced aortic ring contraction in normal as well as Ca2+ free Krebs solutions. The data obtained indicate that talatisamine, 14-benzoylthalatisamine and 14-O-acetylthalatisamine exhibit a pronounced relaxant effect in almost the same way in the case of contraction induced by a high content of KCl and norepinephrine. The mechanism of the relaxant action of alkaloids is probably complex and may include suppression of Ca2+influx through voltage-dependent and receptor-driven Ca2+ channels, as well as inhibition of Ca2+transport in the sarcoplasmic reticulum.
Only Modest Effect of Lipids and Albumin on Apparent Mycophenolic Acid Clearance in Pediatric Transplant Recipients – a Retrospective Cohort Study
Authors: Cuellar Carmen
Published: September 2021

Background: There is growing evidence for the need of therapeutic drug monitoring (TDM) of the active compound Mycophenolic Acid (MPA) of mycophenolate mofetil therapy for the management of antirejection therapy after pediatric renal transplantation. While there is substantial inter- and intra-patient variability of MPA exposure, the factors affecting its apparent clearance (CL/F) are understudied. The objective of this study was to determine the relationship between MPA CL/F, eGFR, creatinine, Cystatin C, triglycerides, cholesterol and albumin. Material and Methods: We calculated 1004 estimated mass-spectrometry-determined MPA CL/F using trough concentrations from 35 pediatric renal transplant patients. Results: Mean age was 8.7±4.6 years at transplant with a median follow-up of 5.8 years. Each patient had a median of 30 MPA trough concentrations. The median MPA AUC was 53.21 mg*h/L, the median CL/F was 8.66 L/h. Univariate and multivariate analysis revealed significant correlations of CL/F with creatinine, triglycerides, cholesterol and albumin, and very weakly with hemoglobin, whereas cystatin C was unrelated. Especially higher lipid levels and weekly, but significantly, lower albumin augmented CL/F. However, the correlations were not strong enough to predict CL/F. Conclusion: The data presented indicate the necessity for MPA TDM and suggest that dose modifications may apply in the face of low serum albumin and hyperlipidemia.
Investigating the antimicrobial activity of extract prepared by ultrasound against Escherichia coli isolated from poultry stool
Authors: Javadian Elham
Published: September 2021

Background: The aim of this study was to investigate the antimicrobial activity of Mentha piperita , Withania somnifera and Rosmarinus officinalis extract on antibiotic resistant Escherichia coli isolated from poultry stool in Zabol city. Materials & Methods: The extract of Mentha piperita, Rosmarinus officinalis and Withania somnifera was prepared by rotary machine. Escherichia coli strains were isolated from poultry stool samples. Minimum inhibitory concentration and minimum bactericidal concentration were determined by microdilution method. Results: The results of this study showed that Mentha piperita extract showed the highest inhibitory ratio compared to other extracts. The minimum inhibitory concentration was 3.1 ppm, with 5 strains inhibited at this concentration. Discussion: The results of this study could be an effective strategy for production and preparation of medicinal plants to help treating E. coli infections.
A short communication nutritional observation study
Authors: Hamouda Asmaa
Published: September 2021

Obesity is the most prevalent nutritional dysfunction in society and the vital risk determinant for several relevant disorders. The first step of obesity assessment is calculated anthropometric measures and, secondly, measure biological and nutritional profiles. The current purpose is to investigate the relationship between BMI with biochemical profile, Vitamin B12, Fe, and cortisol in the volunteer’s population. There is an appositively connection between body mass index (BMI) with cortisol, liver and kidney profile, fasting blood sugar (FBS), Cholesterol, triglyceride, and low-density lipoprotein (LDL) and negative relationship between BMI and Vitamin B12, Fe, and high-density lipoprotein (HDL) in the present study. There is a significant elevation of cortisol, lipid profile, FBS, liver, and kidney function with BMI in the current work in females more than males compared to a reference range, and a significant decrease in Fe and vitamin B that can be due to diet habits, BMI, malabsorption in obesity condition, hormones affect or genetic variations between male and female. That will need further investigation.
Future scope and trends of natural chemistry
Authors: Pandey J.
Published: September 2021

Green science is else called sustainable sciences. The structure is utilized of chemical compounds and techniques that diminish age of perilous i.e. hazardous compound substances. Green science applies corner to corner the life-cycle of a chemical compound, including its assembling, use, plan, and at last removal. Green science is extremely useful in avoidance of contamination at the atomic level, it gives creative scientific arrangements, and it lessens the negative effects of compound on human health and the environment. Green science's 12 standards (Prevent squander, Maximize particle economy, Plan less risky concoction amalgamation, Design more secure synthetic concoctions and items, Use more secure solvents what's more, response conditions and Increase vitality productivity and so on.). Green science assume significant job in pharmaceutical in creating innovatory medicate conveyance strategies which are not so much poisonous but rather more valuable, viable with least symptoms and could help a large number of patients.
The endophytic fungi pestalotiopsis what’s for it and what’s on it?
Authors: Elkhateeb Waill
Published: September 2021

Fungi generally and endophytic ones specifically represent future factories and potent biotechnological tools for production of bioactive natural substances, which could extend healthy life of humanity. Pestalotiopsis is a fungal genus that belongs to family; Sporocadaceae, has been known as a promising secondary metabolites producer. However the same fungus showed harmful pathogenicity against different plants causing crops economical losses. This review is to demonstrate secondary metabolites from the endophytic fungi Pestalotiopsis and some of its reported biological activities. Moreover, describing the unique chemical diversity of this fungal genus involved in medical, pharmaceutical, agricultural applications. Also highlight the harmful side of this important fungus.
Highlights on Chaetomium morphology, secondary metabolites and biological activates
Authors: A. Elkhateeb Waill
Published: September 2021

Endophytic fungi always attract attention due to their generous production of bioactive and chemically novel compounds that have medical, agriculture, industrial applications. This review focused on Chaetomium as a model of endophytic fungi rich in therapeutic agents that have known medicinal and industrial application. Moreover, understanding the importance of this potent fungus encourage further studies to identify novel metabolites, and at the same time employing already known metabolites to evaluate their activity in order to be used in additional applications.
Studi Kelayakan Fiberglass Sebagai Pengganti Kayu Dalam Pembangunan Kapal Nelayan Daerah Bengkalis Pesisir
Authors: B Siswandi , J Jamal , J Jupri , Asrofi Mochamad , Pambudi Setyo
Published: September 2021

Pada umumnya kapal nelayan masyarakat bengkalis terbuat dari kayu. Permasalahan yang dihadapi oleh masyarakat adalah ketersediaan material kayu sebagai bahan baku kapal nelayan saat ini semakin menipis, sehingga diperlukan adanya alternatif material dalam pembangunan kapal nelayan. Berdasarkan hal-hal tersebut maka dilakukan evaluasi dan analisa berkaitan kelayakan material fiberglass sebagai pengganti material kayu dalam pembangunan kapal nelayan. Dengan menggunakan analisis SWOT dilakukan analisa kelayakan fiberglass sebagai pengganti material kayu. Hasil analisa matrik evaluasi faktor internal nilai total faktor didapatkan sebesar 0,27 untuk nilai kekuatan dan pada matrik evaluasi faktor eksternal diapatkan total nilai sebesar 1,62 untuk nilai peluang. Dari nilai tersebut dapat diketahui bahwa fiberglass dapat dijadikan atau layak sebagai material pengganti kayu dalam pembangunan kapal nelayan
Two cases of tits’ fights to the death in competition for winter roosting sites
Authors:   Ornithological Station, Museum and Institute of Zoology, Polish Academy of Sciences, Nadwiślańska 108, 80-680 Gdańsk, Poland, TYPIAK Jakub , TYPIAK Marlena
Published: September 2021

Finding a suitable place for overnight roosting may be crucial for survival during winter. If the number of suitable roosting sites is limited, intra- and interspecific competition may occur. In a nest box group, two cases of tit deaths were recorded in a winter season. The tits had apparent beak marks from pecks on their heads, and so were probably killed by other birds roosting in the boxes. Both dead individuals (a Blue Tit and young female of Great Tit) were competitively weaker individuals considering the hierarchy among wintering tits. They did not belong to the local winter flock. Presence of bird droppings on the bodies of the killed tits indicates that after the fight an individual (probably the winner of the competition) still roosted in the box. In both cases there was at least 57.7% of boxes that were not used by birds, suggesting that the birds fought for the best roosting sites. To the best of our knowledge, these are the first records concerning birds fighting for roosting sites during the winter season, which resulted in a death of one of the competing individuals.
New records and distributional data on the subtribe Staphylinina (Coleoptera: Staphylinidae) from Portugal
Authors: FERREIRA Raul Nascimento
Published: September 2021

Newly found species and new distributional records of the subtribe Staphylinina in Portugal are reported along with some comments on morphological characteristics of each genus. The current review of the subtribe includes 28 species in 8 genera, with two species new for the Portuguese fauna and 25 species and a subspecies recorded from new locations, expanding their geographic distribution.
Pre-service teachers’ decoding skills in information and communication technologies and critical thinking dispositions
Authors: AKGÜL Hakan , ŞAHİN İZMİRLİ Özden
Published: September 2021

This research aims to examine the relationship between the critical thinking dispositions of preservice teachers and their decoding skills in information and communication technologies (decoding skills-ICT). As a research method, survey and correlational research models from quantitative research approaches were used. Research universe is a Faculty of Education at a state university in Turkey. With the use of the convenience sampling method, 262 preservice teachers who voluntarily participated in the online survey constitute the sample of the research. The research data were obtained using the Marmara Critical Thinking Dispositions Scale (MCTDS) and the Decoding Skills in Information and Communication Technologies (decoding skills-ICT) Scale in the 2020-2021 academic year. Among the significant findings of the study are that the average scores of preservice teachers for decoding skills-ICT are at an average level and the average scores for critical thinking dispositions are high. Finally, it has been found in the study that there is a moderately positive relationship between critical thinking dispositions and decoding skills-ICT. According to regression analysis, decoding skills-ICT explains 17.8% of the variance of critical thinking dispositions. This study also aimed to investigate the relationship between decoding skills-ICT and different higher-level thinking skills and to examine the impact of attitudes, dispositions, and skills of different groups of participants on decoding skills-ICT.
Bibliographic review. Existence of virtual museums for educational purposes is applied to the professional environment.
Authors: FRANCESCHİ Roberta , DE MİGUEL Laura
Published: September 2021

Virtual museums are the answer a digital society, a new cultural, social, and economic system and a tool for educational innovation and digital learning. This article aims to collate all relevant evidence in virtual cultural museums with a teaching approach and detect what is published using the following question "What is published about virtual museums for educational purposes?". Its objective is to verify what can be found in the academic field about virtual museums for didactic purposes applied to the professional environment. The research analyzes two hundred and twenty-three articles, of which seventeen were selected for their didactic and professional environment characteristics. The bibliographic review presents indicators that determine a virtual museum is an effective tool both in the field of reinforcing learning, as well as in the theoretical and practical development of activities that encourage creation by students.
PERBEDAAN JARAK TANAM DENGAN METODE LONGLINE BERBINGKAI TERHADAP PERTUMBUHAN RUMPUT LAUT (Eucheuma spinosum)
Authors: Barnus Fadhillah Sudrian , Yusanti Indah Anggraini , Sofian Sofian
Published: September 2021

Rumput Laut (Eucheuma spinosum) merupakan alga golongan coklat yang memiliki nilai ekonomis dan banyak dibudidayakan oleh masyarakat pesisir di Indonesia. Jenis ini banyak dibudidayakan karena mudah dan murah serta prospek pasar yang cukup baik. Penelitian ini bertujuan untuk mengetahui pertumbuhan harian dan pertumbuhan mutlak rumput laut dengan jarak tanam berbeda menggunakan metode long line berbingkai. Penelitian dilakukan selama 50 hari, menggunakan 3 perlakuan yaitu jarak tanam 20cm, 40cm dan 60cm serta pengulangan sebanyak 3 kali, dengan berat awal rumput laut berkisar 50 gram. Data yang dikumpulkan pada penelitian ini yaitu pertumbuhan harian (DGR), pertumbuhan mutlak (AGR) dan parameter kualitas air.Â  Hasil yang diperoleh untuk pertumbuhan harian dan pertumbuhan mutlak rumput laut tertinggi adalah perlakuan P3 dengan jarak tanam 60 Cm sebesar 6,36%/hari dan seberat 1053,9gr, dan kualitas air pada lokasi penelitian masih terbilang baik untuk pertumbuhan rumput laut (Eucheuma spinosum).
GC-MS and Antioxidant Capacity Analysis in Propanol Extract of Carthamus Tinctorious L
Authors: Indriati Sri , Yusuf Muhammad , Riskayanti Riskayanti , Amaliah Nur , Latief Mahyati , Sjafruddin Rahmiah , Attahmid Nur Fitriani Usdyana
Published: September 2021

Safflower, were extracted using propanol solvent at different time intervals: 10, 20, and 30 min at a constant temperature of 40Â°C. The extracts were analyzed by GC/MS technique. The major compounds identified were tetrapentacontane, tetracontane, triacontanol, gamma sitosterol, myristic acid, linoleic acid, stearic acid, palmitic acid, oleic acid, and lauric acid. However, some levels of palmidrol, beta-amyrin, cubenol, and tocopherol were also found in safflower extracts. Most of the volatile compounds were detected between 10â€“30 min time of extraction. The 30 min time of extraction also showed the maximum content of polyphenols and antioxidants in safflower extracts. Thus, 30 min was suggested as the most suitable time for maximum extraction of bioactive volatiles, antioxidants, and polyphenols from Safflower using propanol solvent.
Valuing out of Context
Authors: Gendreau Megs S.
Published: September 2021

While many aspects of human life are vulnerable to the impacts of climate change, values related to selfhood and community are among the most challenging to preserve. In what follows, I focus on the importance of values and valuing in climate change adaptation. To do so, I will first discuss two alternate approaches to valuing, both of which fail to recognise the loss of valued objects and practices that both of which help to generate a sense of self and deserve to be respected and mourned. Ultimately, I argue that an approach to valuing that is responsive to change and open to loss will enable humans to be more resilient in the face of anthropogenic climate change, in order that we may move forward and construct selves that fit the context in which we live.
A Question of Utter Importance: The Early History of Climate Change and Energy Policy in Sweden, 1974-1983
Authors: Ekberg Kristoffer , Hultman Martin
Published: September 2021

This paper studies early arguments in Sweden for combating climate change. We show how scientific results in relation to climate change entered the political sphere as part of the debate on energy in the 1970s, a process we propose to name
energysation
. We argue that the use of climate science by pro-nuclear political actors served as a way of maintaining a course set by a high-energy society while simultaneously trying to outmanoeuvre the growing environmental anti-nuclear and low-energy movement. When the pro-nuclear power side met with resistance, this led to a displacement of climate change knowledge away from the realm of the national political sphere and specific energy forms, a process we conceptualise as
de-energysation
. By highlighting conflicts and the political framings of climate change in the early years 1974-1983, we suggest that the history of these frames influences current delay in climate change mitigation and limits the range of actions and ways of addressing the ongoing climate emergency.
Adoção do método Beneish Score nas empresas públicas brasileiras de capital aberto e o impacto nas suas ações
Authors: Silva Antonio Carlos Magalhães da , Albuquerque Carolina Correa , Vieira Paulo Roberto da Costa
Published: September 2021

A análise dos resultados econômico-financeiros de empresas brasileiras públicas de capital aberto pode indicar a existência de gerenciamento de resultados. Para tanto, foi aplicado a metodologia do Beneish M-Score para a verificação da possibilidade de manipulação de resultados. A contribuição deste artigo está na detecção de aspectos nas empresas geridas pelo Estado que podem permitir a melhoria da gestão pública. A amostra da pesquisa é composta por 17 empresas públicas de capital aberto ao longo de 2005 a 2017. Os resultados são associados à análise dos retornos das ações destas empresas no mercado e aspectos relevantes ocorridos nas empresas no ano em que foi detectado indicação pelo modelo adotado. Os resultados obtidos indicaram a possiblidade de manipulação de resultados recorrentes ao longo da base de dados do trabalho em determinadas empresas
mercado brasileiro de quadrinhos
Authors: Cerqueira Leonardo Alvim , Dornelas Tatiana
Published: September 2021

Histórias em quadrinhos e crianças são dois tópicos geralmente associados, mas nem todo quadrinho é destinado ao público infantil. O objetivo deste trabalho é fazer uma análise descritiva de como as organizações que atuam neste segmento atuam e como enxergam este mercado. Os conceitos abordam temas como os consumidores, o desenvolvimento de produto, a divulgação e distribuição. Foram coletados dados que descrevem como é a atuação das organizações deste ramo e foi realizada uma entrevista com uma editora, a fim de descobrirmos sua visão sobre o atual momento do mercado. O trabalho apresenta e desmistifica um importante ramo da economia criativa, apresentando os quadrinhos como uma forma de entretenimento para diversos públicos com a mais variada faixa etária.
Validation of mRNAs in Early Diagnosis and Treatment of Hepatocellular Carcinoma
Authors: Khalid Iqra , Quraishi Azra , Fiaz Freeha
Published: September 2021

Poor and late diagnosis of HCV is main the cause of liver cancer. MicroRNAs are non-coding molecules that are involved in regulation of a variety of functions happening in the cell, in healthy and diseased state. Dysregulation of microRNAs is observed in different diseases, especially in liver cancer like hepatocellular carcinoma. The available detection methods detect HCC at a late stage. There is a need to find novel biomarkers for diagnosis at an earlier stage to minimize chances of liver cancer. Circulating microRNAs are novel and minimal invasive markers for early detection of HCV based hepatocellular carcinoma. In this review, the current progress on the potential role of miRNA as biomarkers for detection of HCC and therapeutic targets are summarized. We concluded that the expression of microRNAis upregulated in the patients of hepatocellular carcinoma when compared with the healthy ones. In-depth studies of miRNA in patients of HCC as genetic biomarkers will improve the diagnosis. It will also improve the prognosis of early stage HCC patients. This will also help in identifying a suitable and effective therapeutic targets so as to reduce the chances of failure of chemotherapy.
Selection Criteria for Conventional and Islamic Banks: An Empirical Analysis
Authors: Atiq uz Zafar  , Malik Muhammad  , Bibi Akhtar
Published: September 2021

The current study investigates the bank selection criteria used by the customers of both the conventional and Islamic banks of Pakistan. From six different cities, a sample of 1000 customers was selected in order to find out the factors influencing their selection of a bank. The results showed that “Security of Money” was considered as the most important factor in the selection of banks, both by the customers of conventional and Islamic banks. The results also revealed that the customers of Islamic banks ranked “Competence of Staff”, “Online Banking Facility”, and “Confidentiality of Information” as the second, third and fourth most important factors in the selection of their respective banks. On the other hand, the customers of conventional banks emphasized “Availability of ATM Machines”, “Quick Service”, and “Friendly Behavior of Staff” as the second, third and fourth most important factors in bank selection. Further, the customers of Islamic banks ranked “Shari’ah Compliance” as the seventh most important factor, while the customers of conventional banks ranked it as the twentieth important factor out of the total twenty-five factors. Thus, to retain the existing customers and to attract new ones, both Islamic and conventional banks need to focus on customer preferences when offering their products.
Maritime Management: Micro and Small Businesses
Authors: Pauley Matthew
Published: September 2021

This textbook focuses on the theory and practicality of operating a micro and/or small business.
Bariatric and metabolic surgery during the COVID-19 crisis: strategies facing two pandemics
Authors: Lasses Martínez B. , Dziakova J. , Torres A.
Published: September 2021

Since its first appearance in Wuhan at the end of 2019, the SARS-CoV-2 pandemic has brought serious repercussions worldwide, Spain being among the most affected countries. This health crisis resulted in the cancellation of surgeries pertaining to both malignant and benign pathologies, including bariatric and metabolic surgery. Patients with morbid obesity, besides their delay in surgical interventions, are at high risk of contracting severe COVID-19. For this reason, once the epidemiological situation has improved in our hospitals and the necessary resources become again available, this surgical activity should be progressively restarted. The goal of this paper is to review the published literature regarding the main perioperative recommendations concerning safe bariatric and metabolic surgery during the COVID-19 pandemic.