bluuebunny/crossref_metadata_2025 huggingface dataset:
COVID-19 with acute hepatitis A virus co-infection in a fully-vaccinated individual: a case report
Authors: Siregar Masra Lena , Putradasa Rabid Yahya , Nisaul Arini , Muzakkir Suheir
Published: September 2021

In a developing country with varying degree of public hygiene and sanitation, prevalent infectious diseases such as hepatitis A (HAV) could add to the burden of infection during coronavirus disease 2019 (COVID-19) pandemic and complicate its gastrointestinal and hepatic manifestation. Here we present a case COVID-19 with acute hepatitis A virus co-infection in a young female with fever, joint pain, non-productive cough, loss of smell, abdominal discomfort, darkened urine, and pale loose stool before admission. The significant finding was slightly icteric sclera, hepatomegaly with tenderness in the epigastrium and right upper quadrant, increase in aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total bilirubin, C-reactive protein and, D-dimer. A naso-oropharyngeal swab examination for SARS-CoV-2 infection was positive, and IgM anti-HAV was reactive with a total anti-HAV titer 60 mIU/mL. Subsequently, she was hospitalized for 14 days, successfully recovered; her symptoms resolved and her level of liver enzymes back to normal, and she was discharged for self-isolation at home. RT-PCR for SARS-CoV-2 infection came back negative 7 days later. In light of the pandemic, physicians need to raise suspicion of co-infection of COVID-19 with other hepatitis viruses in cases with gastrointestinal and hepatic manifestation. A marked increase in liver enzyme may warrant further testing for hepatitis viruses where such infection should be suspected.
Ramadan and Eid al-Fitr: Population movement, mass gathering and escalating of COVID-19 – A perspective from Indonesia
Authors: Arsyad Dian Sidik , Nainu Firzan , Wagner Abram L. , Dhama Kuldeep
Published: September 2021

In Indonesia, the most populous Moslem-majority country, despite the possibility of underreported coronavirus disease (COVID-19) cases, 6,248 confirmed cases and 535 deaths have been recorded. With upcoming Ramadan and Eid al-Fitr, between 18-23 million of Indonesians may move from urban locations (with high counts of COVDI-19) to rural areas with fewer cases currently but less laboratory capacity to diagnose cases. This review summaries the current situation of CO.VID-19 in Indonesia and discusses the possible impacts of mass population movement, Ramadan-related activities, and Eid al-Fitr celebration days on COVID-19 transmission in the country.
RETROSPECTIVE ANALYSIS OF THE PARASITIC CONTAMINATION OF SOIL SAMPLED IN THE ASTRAKHAN REGION IN 2011-2015
Authors:   Arakelyan Rudolf Sergeevich Candidate of Medical Sciences, Associate Professor, Associate Professor of the Department of Infectious Diseases and Epidemiology, Astrakhan State Medical University, Vasilievna N.T. , SALIKHOV N.Z. , BOLDYREVA A.I.
Published: September 2021

To study and analyze the parasitic contamination of soil in the Astrakhan region in 2011-2015.
THE EFFECT OF THE MENSTRUAL CYCLE PHASE ON THE OUTCOME OF AUGMENTATION MAMMOPLASTY
Authors:   M.F. Vladimirsky Moscow Regional Research and Clinical Institute, Moscow, Russian Federation, FAYZULLIN T.R.
Published: September 2021

To determine the optimal timing for augmentation mammoplasty (AM) relative to the menstrual cycle phase.
PREVALENCE OF MYCOBACTERIUM TUBERCULOSIS AMONG CHILDREN AT THE RESERVOIRS OF INFECTION IN THE REPUBLIC OF TAJIKISTAN
Authors:   Department of Phthisiopulmonology, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan, BOBOKHOJAEV O.I. , SIRODJIDINOVA U.YU. , SAYDALIEV S.M. , BOZOROVA R.S. ,   Department of Functional Diagnostics and Clinical Laboratory, Tajik National University, Dushanbe, Republic of Tajikistan
Published: September 2021

To study the prevalence of Mycobacterium tuberculosis at the infection reservoirs in the Republic of Tajikistan among children and the impact of BCG vaccination assessed by tuberculin skin test.
ANTITUBERCULOSIS DRUG ALLERGY IN PATIENTS WITH MULTIDRUG-RESISTANT TUBERCULOSIS
Authors:   National Center for Phthisiology, Bishkek, Kyrgyz Republic, MAYKANAEV B.B. , TOKTOGONOVA A.A. , DUDENKO E.V. , SYDYKOVA S.
Published: September 2021

To identify allergic reactions (AR) to anti-tuberculosis drugs (ATD) in patients with multidrug-resistant tuberculosis (MDR-TB).
SURGICAL TREATMENT STRATEGIES FOR GIANT ANTERIOR ABDOMINAL WALL HERNIAS
Authors:   Department of Surgical Diseases № 2 named after Academician N.U. Usmanov, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan, MALIKOV M.KH. , BOKIEV F.B. ,   Republican Scientific Center for Cardiovascular Surgery, Dushanbe, Republic of Tajikistan, KHUDOYDODOV O. M. ,   Department of Surgical Diseases № 2 named after Academician N.U. Usmanov, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan, KHOMIDOV I.T. ,   Department of Surgical Diseases № 2 named after Academician N.U. Usmanov, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan, KHOMIDOV F.M. ,   Department of Surgical Diseases № 2 named after Academician N.U. Usmanov, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan, MAKHMADKULOVA N.A. ,   Department of Operative Surgery and Topographic Anatomy, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
Published: September 2021

To improve surgical treatment of giant hernias of the anterior abdominal wall (AAW).
MAIN ASPECTS OF ADHESIVE SMALL BOWEL OBSTRUCTION
Authors:   Department of General Surgery № 1, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan, GULOV M.K. , SALIMOV D.S. ,   Department of General Surgery № 1, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan, ALI-ZADE S.G. ,   Department of Surgical Diseases № 1, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan, DOSTIEV A.R. ,   Department of General Surgery № 1, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan, KOBILOV I.I. ,   Department of General Surgery № 1, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan
Published: September 2021

Immediacy of the problem of acute adhesive small bowel obstruction (AASBO) is due to its high prevalence and presence of certain difficulties in diagnosis, which affect the choice of the treatment method. In addition, the long-term results of treatment cannot be considered satisfactory due to the large number of AASBO recurrences. In 64-93% of cases, adhesions form on the abdominal organs after surgery. It should be noted that their recurrence after open surgery reaches 30% of cases, and after repeated operations this value increases to 78%. Determination of the main etiological factor is of great importance, which makes it possible to assess the feasibility surgery, since it is known that if adhesions do not develop, treatment can be conservative. In this regard, X-ray methods of investigation can be of great help. Surgical intervention is recommended in the presence of intestinal dysfunction symptoms that do not disappear after conservative treatment or when it worsens. Surgical intervention is recommended if symptoms of intestinal dysfunction do not disappear after conservative treatment or if they deteriorate. n recent decades, specialists in the field of abdominal surgery have been striving to expand the indications for laparoscopic interventions in order to reduce the invasiveness of surgery, which will also decrease the risk of adhesions. Keywords: Bowel obstruction, small intestine, surgery, adhesions, laparoscopic adhesiolysis.
RISK OF OCCUPATIONAL, WORK-RELATED, AND SOMATIC MORBIDITY AMONG METALLURGICAL INDUSTRIES WORKERS
Authors:   Ufa Research Institute of Occupational Health and Human Ecology, Ufa, Russian Federation, MASYAGUTOVA L.M. , ABDRAKHMANOVA E.R. ,   Ufa Research Institute of Occupational Health and Human Ecology, Ufa, Russian Federation. Bashkir State Medical University, Ufa, Russian Federation., GABDULVALEEVA E.F. ,   Ufa Research Institute of Occupational Health and Human Ecology, Ufa, Russian Federation, PERMINOVA V.A. ,   Bashkir State Medical University, Ufa, Russian Federation
Published: September 2021

Presently, occupational and work-related diseases make up a significant share of disability and mortality causes among the working-age population. However, to a greater extent, this is linked with the peculiarities of production rather than injuries at the workplace. In contemporary Russia, the significance of the problem is highlighted by the fact that up to 70% of metallurgical enterprises are the principal employer and mainstay of an entire town for the bulk of the employable population.
ANATOMICAL EVIDENCE OF ACUPUNCTURE POINTS AND THE MERIDIANS IN CHINESE TRADITIONAL MEDICINE
Authors:   Department of Normal Physiology, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan, SHUKUROV F.A. , LEE S.U. ,   Department of Normal Physiology, Avicenna Tajik State Medical University, Dushanbe, Republic of Tajikistan, KAROMATOV I.D. ,   Department of Traditional Medicine and Occupational Diseases, Bukhara State Medical Institute named after Abu Ali ibn Sino, Bukhara. Republic of Uzbekistan
Published: September 2021

The review summarizes studies related to current issues and concepts of the neuroanatomic basis of the meridian system and acupuncture points. The proponents of their existence have not yet come to any consensus on how they might work or be tested in a scientific context. Kim Bonghan, a professor at Pyongyang Medical University of the Democratic People’s Republic of Korea, discovered the anatomical structure of meridian collaterals, which he called the Bonghan corpuscles (now known as primo nodes) and the the Bonghan ducts (primo vessels), and called it the Bonghan (Kyungrak) system. In 2010, it was renamed into the primo vascular system (PVS), which exists throughout the organism, including blood and lymph vessels. PVS is an anatomical structure being a network of ducts with fluid flowing in them. This system consists of primo-vessels and primo-nodes, corresponding to acupuncture meridians, and acupuncture points, respectively. Thus, the PVS can serve as a morphological substrate for acupuncture points and meridians of traditional Chinese medicine; however, since there is no scientific consensus on the neuroanatomical basis of acupuncture, further morphological, physiological, and clinical studies are needed to promote a broader mutual understanding of this issue in the research community and beyond.
Transesterificación de aceite de palma (Elaeis guineensis x Elaeis oleífera) empleando catalizadores ácidos heterogéneos y agitación ultrasónica
Authors: Ramírez Alfonso E. , Imbachí Yudi C. , Miranda Cristian D.
Published: September 2021

En este estudio se reportan los resultados de la transesterificación del aceite de palma (Elaeis guineensis x Elaeis oleífera) utilizando catalizadores ácidos heterogéneos como la zirconia sulfatada (ZS), óxido de grafeno lfonado (OGrS), Amberlyst 15 (A15) y zeolita beta (Zβ)ueron caracterizados mediante el uso de difracción de rayos X, área superficial, y acidez de Brønsted - Lewis. Se evaluaron parámetros de reacción tales como: temperatura, tiempo de reacción, el porcentaje en peso de carga de catalizador y la relación molar de aceite metanol para la producción de biodiesel. Adicionalmente, se comparó la agitación mecánica y la ultrasónicadonde la segunda fue el medio de agitación más eficiente. Los mejores porcentajes de rendimiento de reacción fueron obtenidos empleando 40ºC de temperatura, 4 horas de reacción, 3% en peso del catalizador respecto al volumen total de la mezcla, una relación molar 1:30 de aceite de palma: metanol y agitación ultrasónica. En cuanto a la estabilidad de los catalizadores, se evaluó el rendimiento de la reacción con la reutilización, en donde los sólidos ZS y OGrS disminuyeron 8 % y 35 %, mientras que con A15 y Zβ, se redujo a 25 % y 5 % respectivamente.
In silico Design of Novel N-hydrosulfonylbenzamides inhibitors of dengue RNA-dependent RNA polymerase showing favorable predicted pharmacokinetic profiles
Authors:   Laboratoire de Physique Fondamentale et Appliquée (LPFA), University of Abobo Adjamé (now Nangui Abrogoua), Abidjan, Côte d’Ivoire, Jean-Louis Kouakou Kouakou , Keita Melalie , Elvice Esmel Akori , Dali Brice , N'Guessan Aubin , Florance Kouassi Affiba
Published: September 2021

Background: In recent years, there has been a growing interest in Denv NS5 inhibition, with several reported RdRp inhibitors such as sulfonylbenzamides, non-nucleo-side inhibitors without any 3D-QSAR pharmacophore (PH4) available. In this context, we report here, in silico design and virtual evaluation of novel sulfonylbenzamides Denv RdRp inhibitors with favorable predicted pharmacokinetic profile. Methods: By using in situ modifications of the crystal structure of 5-(5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl)-4- methoxy-2-methyl-N-(methylsulfonyl) benzamide (EHB)-RdRp complex (PDB entry 5HMZ), 3D models of RdRp-EHBx complexes were prepared for a training set of 18 EHBs with experimentally determined inhibitory potencies (half-maximal inhibitory concentrations IC50exp). In the search for active conformation of the EHB1-18, linear QSAR model was prepared, which correlated computed gas phase enthalpies of formation ∆∆HMM of RdRp-EHBx complexes with the IC50exp. Further, considering the solvent effect and entropy changes upon ligand binding resulted in a superior QSAR model correlating computed complexation Gibbs free energies (∆∆Gcom). The successive pharmacophore model (PH4) generated from the active conformations of EHBs served as a virtual screening tool of novel analogs included in a virtual combinatorial library (VCL) of compounds with scaffolds restricted to phenyl. The VCL filtered by the Lipinski’s rule-of-five was screened by the PH4 model to identify new EHB analogs. Results: Gas phase QSAR model: -log10(IC50exp) = p IC50exp =-0.1403 x ∆∆HMM _ 7.0879, R2 = 0.73; superior aqueous phase QSAR model: p IC50exp = -0.2036 x ∆∆Gcom + 7.4974, R2 = 0.81 and PH4 pharmacophore model: p IC50exp = 1.0001 x p IC50pre -0.0017, R2 = 0.97. The VCL of more than 30 million EHBs was filtered down to 125,915 analogs Lipinski’s rule. The five-point PH4 screening retained 329 new and potent EHBs with predicted inhibitory potencies p IC50pre up to 30 times lower than that of EHB1 (IC50exp = 23nM). Predicted pharmacokinetic profile of the new analogs showed enhanced cell membrane permeability and high human oral absorption compared to the alone drug to treat dengue virus. Conclusions: Combined use of QSAR models, which considered binding of the EHBs to RdRp, pharmacophore model and ADME properties helped to recognize bound active conformation of the sulfonylbenzamide inhibitors, permitted in silico screening of VCL of compounds sharing sulfonylbenzamide scaffold and identify new analogs with predicted high inhibitory potencies and favorable pharmacokinetic profiles. Keywords: ADME properties prediction, Dengue, 3-(5-ethynylthiophen-2-yl)-N-hydrosulfonylbenzamides, in silico screening, RNA-dependent RNA polymerase.
Conformational analysis and molecular design of anthranilic acid derivatives as partial agonists of the Farnesoid X Receptor (FXR) with favorable predicted pharmacokinetic profiles
Authors:   Laboratoire de Physique Fondamentale et Appliquée (LPFA), University of Abobo Adjamé (now Nangui Abrogoua), Abidjan 02, Côte d’Ivoire, Banquet OKRA Guy Müller , Brice Dali , N'Guessan Hermann , Florance Kouassi Affiba , Raymond Kre N’Guessan
Published: September 2021

We report here virtual design of new anthranilic acid derivatives (AAD) identified as potent partial Farnesoid X recep-tor (FXR) agonists with favorable predicted pharmacokinetic profiles. By in situ modification of the crystal structure (PDB ID: 3OLF) of FXR complex with a benzimidazole-based partial agonistic ligand, 3D models of 17 FXR:AADx complexes with known observed activity (EC50exp) were prepared to establish a quantitative structure–activity (QSAR) model and linear correla-tion between relative Gibbs free energy (GFE) of receptor-ligand complex formation (Gcom) and EC50exp: pEC50exp = -0,1146 Gcom + 8,175 (#); R2 = 0.98. A 3D QSAR pharmacophore model (PH4) derived from the QSAR directed our effort to design novel AAD analogs. During the design, an initial virtual library of 94501 AAD was focused down to 33134 drug-like compounds and finally, PH4 screened to identify 100 promising compounds. Theoretical EC50 (EC50pre) values of all analogs compounds were predicted by means of equation (#) and their pharmacokinetics (ADME) profiles were computed. More than 12 putative AADs display EC50pre 300 times superior to that of the reported most active training set inhibitor AAD1.
Chylous peritonitis in peritoneal dialysis
Authors: Abid Hanen , Toumi Salma , Chaker Hanen , Fandri Beya , Agrebi Ikram , Dammak Najla , Mseddi Fatma , Kammoun Khawla , Yaich Soumaya , Ben Hmida Mohamed
Published: September 2021

Chylous peritonitis (CP) is a rare complication in patients on peritoneal dialysis. There are many reasons for this. It can occur as a result of a traumatic insertion of the peritoneal dialysis catheter or secondary to infectious or drug causes. The evolution is favorable at the elimination of the causative agent.

We report 3 cases of PC occurring in 3 patients on peritoneal dialysis. In 2 patients, CP was secondary to calcium channel blockers and in 1 case associated with lymph node tuberculosis. The cessation of the causative agent allowed a clarification of the effluent dialysate. CP is a mild form of non-infectious peritonitis that is often confused with infectious peritonitis. In this article we discuss the etiologies of CPs, the pathophysiology and the conduct to be held in front of a CP.
Prevention of browning reaction in banana jam during storage by physical and
chemical treatments
Authors: Aimi Azira S. , Wan Zunairah W.I. , Nor Afizah M. , M.A.R. Nor-Khaizura , S. Radhiah , M.R. Ismail Fitry , Z.A. Nur Hanani
Published: September 2021

Bananas are fruits that quickly turn brown after being peeled or cooked. The browning
reaction reduces the quality of the appearance and shelf life of banana jam. Therefore, this
study was aimed to evaluate the effect of chemical blanching and anti-browning agents on
reducing browning reactions and maintaining the quality of banana jam during storage. In
this study, Musa paradisiaca cv. Nipah was used to produce banana jam. The banana jam
was prepared using three different treatments. The first treatment was prepared without
hot water blanching treatment and with the addition of ascorbic acid and sodium
metabisulphite. The jam was prepared with banana pulp, sugar, citric acid, and pectin.
This treatment act as a control. The banana jam for the second and third treatments was
prepared using the same ingredients as treatment one. In the second treatment, the sliced
banana was blanched in hot water (80°C) for 10 mins, whereas in treatment three, the
banana slices were dipped into 1.5% of ascorbic acid solution at 80°C for 10 mins. During
the cooking process, 0.1% of sodium metabisulphite was added into the jam, for
treatments two and three. The jam was cooked until the temperature reached 105°C and
the total soluble solids range from 68 - 70°Bx. The banana jam was filled in glass jars,
sterilized in a hot water bath at 80°C for 10 mins, cooled to 27°C (room temperature)
before being stored at room temperature. The analysis observed were pH, total soluble
solids, titrable acidity, colour, browning index, and textural properties. The samples were
stored at room temperature for 60 days. The observations were made every 15 days for
two months. After 60 days of storage, all treatments showed positive changes and a
significant difference (p<0.05) in physicochemical and texture analyses. Overall, hot
water blanching and chemical treatments significantly reduced the browning reaction in
the banana jam. Therefore, treatment three had the best ability to slow down the browning
reaction and deterioration rate of banana jam during room temperature storage.
Whey beverage improves hydrating capacity of the soccer players
Authors: Hernandez Miranda J. , Soto Simental S. , Guemes Vera N. , Piloni Martini J. , Quintero Lira A. , Rodriguez Avila J.A.
Published: September 2021

The hydration process is critical in soccer players. The hydrating capacity, energy
recovery, and electrolyte excretion in urine were determined by the use of a whey
beverage as a hydration medium for high-performance athletes compared to the effects of
purified water and a sport beverage. The study was carried out through an approved
research protocol, which contemplates the determination of hydrating capacity by
monitoring body weight during a period of exercise and a subsequent hydration period.
Energy recovery was determined by monitoring blood glucose levels and electrolyte
excretion was performed by quantifying the concentration of sodium (Na+
), potassium
(K+
), calcium (Ca2+) and magnesium (Mg2+) in urine samples provided by the participants
during the research protocol. It was concluded that the whey beverage has an appropriate
capacity for hydration and energy recovery, while with regard to minerals it was observed
that it effectively regulates the excretion of Na+
, Ca2+ and Mg2+
.
Microwave-assisted extraction and characterization of pectin from citrus fruit
wastes for commercial application
Authors: Mahmud M.M. , Belal M. , Ahmed S. , Hoque M.M. , Zzaman W.
Published: September 2021

Pectin is an essential hydrocolloid widely used as a gelling, thickening, and stabilizing
agent in the food, pharmaceutical, and cosmetic industry. In the present study, an effort
has been made to extract pectin from Pomelo (Citrus maxima), Kinnow mandarin (Citrus
reticulata) and Citron (Citrus medica) peels with microwave-assisted extraction (MAE)
technique using organic citric acid. Pectin extracted with MAE was characterized in terms
of yield, ash content, pH, solubility, equivalent weight, methoxyl content, anhydrouronic
acid content, and degree of esterification. The extraction conditions had significant effects
on physicochemical properties. The results showed that the highest amount of pectin
(24.19±0.26%) was obtained from Citrus maxima. Based on DE value all pectins were
categorized as low methoxy pectin (LMF). Extracted pectins were highly pure based on
AUA content. Structural characterization of extracted pectin from three fruit peels by
Fourier Transform Infrared (FT-IR) spectroscopy revealed that pectin has functional
groups within the 1740–800 cm-1
spectral region. However, pectin extracted in this study
can be used in the manufacturing of low sugar foods such as diet jams and jellies.
Characteristic of isolated crude bromelain extract from cayenne pineapple crown in various drying temperature and its effect on meat texture
Authors: Rizqiati H. , Nugraheni A. , Susanti S. , Fatmawati L. , Nuryanto N. , Arifan F.
Published: September 2021

Bromelain enzyme is a protease enzyme that is abundantly found in pineapples. Pineapple
crown is a part of pineapple that contains bromelain enzyme which its content remains
unknown. This study was aimed to discover the effect of drying on the moisture content,
yield, and characteristics of the enzyme of cayenne pineapple crown, namely protein
content, activity units and specific activities. This study also aimed to discover its effect
on the beef texture with a difference in duration in the immersion process. The method
used was different drying temperatures of 55oC, 50oC, 45oC, 40oC, 35oC, and 30oC which
was analysed descriptively and the difference of immersion duration in beef using the
Completely Randomized Design (CRD) method with four treatments, namely immersion
duration of 0-hour, 2-hrs, 4-hrs, 6-hrs with 5 repetitions. The results obtained was the
optimal drying temperature was 55oC due to its best moisture content, protein content, and
best enzyme characteristics and it was known that there was a significant effect (p<0.05)
of immersion duration on the meat texture with the optimal immersion duration of 4 hrs
with the best texture.
P. VIGANÒ - Territories of Urbanism: The Project as Knowledge Producer
Authors: Monclús Fraga Javier
Published: September 2021

Paola ViganòTerritories of Urbanism: The Project as Knowledge ProducerLausanne: EPFL Press, 2016. 300 pp. Tapa dura. Idioma: inglés. 53 € ISBN-10: 2940222894ISBN-13: 978-2940222896
F. TOPPETTI - Arquitectura en tiempo presente. Lo moderno incluye lo contemporáneo
Authors: Gómez Díaz Francisco , Navarro de Pablos Javier
Published: September 2021

Fabrizio ToppettiArquitectura en tiempo presente. Lo moderno incluye lo contemporáneoBuenos Aires: Ediciones Infinito, 2019 [Primera edición en italiano, abril de 2018]. 157 pp. Tapa blanda. Idioma: español. 18 €ISBN: 978-987-3970-16-0
ARTICLES OF THE CRIMINAL LEGISLATION OF THE RUSSIAN FEDERATION CONCERNING ADVERSE CONSEQUENCES FOR HUMAN HEALTH AND LIFE
Authors: A.P. Bozhchenko , M.T. Ismailov , A.A. Gomon , E.S. Griga , Yu.A. Khrustaleva
Published: September 2021

The article is devoted to the analysis of the current criminal legislation of the Russian Federation in relation to crimes that provide for liability for causing harm to human health, in order to improve expert and legal tools for determining adverse consequences for human health and life. Research material: the Criminal Code of the Russian Federation and its comments. Research methods: selection and fixation of information, grouping of data, comparison, analysis and generalization of the identified patterns. As a result of the conducted research, a complete list of articles providing for liability for causing serious (51 in total), moderate (30) and minor harm to health (27) was determined. There are articles in which the severity of the harm to health is not specified (10) or the vague term "significant harm" is used (1). A number of articles (26) have been identified, in which the term "harm to health" is used instead of the term "violence", which is specified in the Decisions of the Plenum of the Supreme Court of the Russian Federation or comments to the Criminal Code of the Russian Federation as "harm to health". It is concluded that the concept of harm to health formed in the criminal legislation is broader than the one established in forensic medicine. In the current legislation, there is an abundance and heterogeneity of terms used to describe independent types of adverse effects on human health and life. Unification of the concept of harm caused to human health is required. An original definition of this concept is proposed.
MICROORGANISMS AS INDICATORS OF SOIL QUALITY
Authors: R.S. Kosumov , Z.P. Okazova
Published: September 2021

The first bioassays for environmental monitoring were based on multicellular eukaryotic organisms, in particular fish and mammals. Because they were relatively expensive, time consuming and difficult, there was a need for alternative biological monitoring methods. It became necessary to develop and standardize toxicity tests based on prokaryotic (bacteria) or eukaryotic (protozoa, unicellular algae, yeast) microorganisms instead of higher organisms, which made it possible to quickly and inexpensively screen environmental samples for toxic and genotoxic effects. The first generation of bioassays was based on a variety of naturally sensitive microbes, while the second generation includes genetically modified microorganisms to achieve greater sensitivity and / or specificity. The next step forward was the combination of microbial cells, or parts of cells, with physicochemical detection elements, forming new integrated devices called "biosensors". The purpose of the research is to study the possibility of using microorganisms in bioindication of environmental pollution. The use of biological methods in environmental monitoring is essential to complement chemical analyzes with information on actual toxicity. Microorganisms are widely used as test objects for analyzes due to the simplicity and low cost of their cultivation. The use of microorganisms for the assessment of general toxicity or the detection of specific compounds is an important source of information on the state of the environment. Their use will significantly expand the range of environmental studies.
THE INFLUENCE OF ABSINTHE ON WORLD CULTURE
Authors: I.A. Beloglazov , N.V. Biryukova , N.V. Nesterova
Published: September 2021

The authors of the work analyzed the sources that characterize the influence of absinthe on human culture. Absinthe, an alcoholic drink containing wormwood (Artemisia absinthium L.), was banned in the early 20th century due to unusual properties attributed to the side effects of drinking this alcohol. This review contains information about the history of the drink. On the one hand, absinthe left its mark in the culture as a “muse” for the creators, remaining forever imprinted in the works of various types of art, on the other hand, it became the main enemy for the most part of society because of the harmful properties that was characterized by researchers of the 19th century.
HEALTH-SAVING TECHNOLOGIES AS SOCIAL PRACTICES IN THE MODERN RUSSIAN FAMILY
Authors: A.S. Krul
Published: September 2021

The paper presents a study of modern social practices of health care in the family. The problem of research is determined by the need to implement health-saving technologies such as living conditions and family life, as well as the introduction of social practices of healthy lifestyles in primary groups. The relevance of the topic is determined by the conditions for the development of modern Russian society, which are characterized by the need to form a social institution of healthy lifestyle and mandatory components in the form of social practices for informal groups. From this perspective, the natural course of development is the institution of the family, which takes on the task of introducing a healthy lifestyle as a system of daily activities. The study is based on the institutional analysis of health-preserving technologies in the family, the basis for the analysis was the theoretical and methodological principles of studying society as a social system (T. Parsons, N. Luhmann). The model for representing health-saving technologies in the everyday practices of the modern Russian family is based on the model of systems of social actions by T. Parsons and the model of the functioning of the family as a social institution by R. Merton. The empirical base is based on the author's sociological research: a survey, an expert survey, document analysis, macrosociological analysis and modeling (from 2016 to 2021), as well as the results of studies conducted by All-Russia Public Opinion Research Center (VCIOM), The Levada Center (2018). As a result of the research, an analysis of the social practices of a healthy lifestyle in a modern Russian family was carried out; the components of a healthy lifestyle were presented as a condition for the development of health-saving technologies in the daily actions of an individual. The model of social practices of healthy lifestyles in a modern Russian family is based on the institutional analysis of the family.
THE RELATIONSHIP OF THE ANTIBACTERIAL ACTIVITY OF A PLANT SPECIES WITH CHEMICAL COMPOUNDS OF DIFFERENT GROUPS: A STATISTICAL APPROACH
Authors: P.L. Popov
Published: September 2021

The article deals with the question of the statistical attraction of chemical compounds that have an antibacterial effect and belong to various groups (terpenoids, phenols, flavonoids, quinones, alkaloids, lactones, coumarins, iridoids, xanthones) to the same types of plants. To assess the occurrence of species containing an antibacterial compound of a certain group in a set of species containing an antibacterial compound of another group (in comparison with the species of the flora of the Russian Federation outside this set), the student’s mathematical and statistical criterion was used. It is shown that in 12 combinations of groups ("terpenoids-phenols", "terpenoids-flavonoids", "terpenoids-quinones", "terpenoids-coumarins", "phenols-flavonoids". "Phenols-quinones", "phenols-coumarins", "flavonoids-coumarins", "flavonoids-iridoids", "flavonoids-xanthones", "lactones-coumarins") the occurrence of species containing an antibacterial compound related to one element of the combination is significantly increased in the set of species containing an antibacterial compound related to another element. It is noted that these statistical relationships are created by species belonging to 19 families of the flora of the Russian Federation (Iridaceae, Ranunculaceae, Chenopodyaceae, Ericaceae, Pyrolaceae, Salicaceae, Brassicaceae, Moraceae, Crassulaceae, Rosaceae, Fabaceae, Apiaceae, Valerianaceae,Viburnaceae,Rubiacae,Gentianaceae, Scrophulariaceae, Lamiaceae, Asteracaeae).
PATIENT SELECTION FOR THE LASER TREATMENT BY ESTIMATION OF THE THERAPEUTIC FAILURE PROBABILITY OF SURGICAL TREATMENT
Authors: S.I. Vyrmaskin , D.A. Trunin , V.V. Afanasev
Published: September 2021

The study is dedicated to the study of inflammatory and destructive periodontal diseases. Predicting the probability of a favorable outcome or treatment failure is one of the most important doctor’s tasks when choosing a particular method. This problem could not be solved without using a large amount of data characterizing the patient's condition at a particular point in time. The empirical approach to this problem depends largely on individual experience and does not imply obtaining any formalized (numerical) probability estimates of successful or, on the contrary, unsuccessful end of treatment. Correct and effective using of dental lasers in clinical practice requires knowledge of their effects on tissues of the oral cavity. Each type of laser has its properties that are used to solve clinical cases. Laser radiation requires an approach that is significantly different from the traditional use of dental instruments. To determine lasers therapeutic indications for the treatment of inflammatory and destructive periodontal diseases, we applied biometric approaches to the development of mathematical models using multidimensional analysis, allowing to obtain qualitative assessments for optimization of method and treatment strategy selection. The development of predictive models was carried out in several stages. Each of the generally accepted dental signs characterizing periodontal disease could not be a reliable criterion for the effectiveness or ineffectiveness of surgical treatment. Comprehensive assessment using a logistic (exponential) model of the probability of a particular treatment outcome with a high degree statistical reliability makes it possible to select patients for whom treatment with laser technologies is recommended.
ESTIMATION OF THE DENTAL STATUS IN PERSONS IN THE INVESTIGATIVE INSULATOR
Authors: O.A. Uspenskaya , A.A. Plishkina , M.L. Zhdanova , I.P. Goryacheva , E.E. Kuz'micheva
Published: September 2021

This study assessed the level of dental health in the special contingent, identified the main factors that had a negative impact on the condition of the prisoners' oral cavity, the main diseases of the oral cavity, and also revealed a high prevalence of HIV infection and hepatitis among them. Analyzing the survey data of 150 prisoners in the remand prison, the following conclusion can be drawn. For the most part, persons in prison have a low social status and a high level of dental morbidity. Caries, periodontal diseases, leukoplakia, xerostomia were noted among the most common diseases of the oral cavity. In prisons, inmates are exposed to a number of factors that have a negative impact on their oral health and the body as a whole. The high prevalence of HIV and hepatitis among them also affects the oral health of prisoners. In the course of the study, it was found that the prevalence of leukoplakia (K13.2) is 40% (N = 60), xerostomia (K11.7) - 32% (N = 48), the prevalence of periodontal disease (K05.3) among prisoners is 76% (N = 114), caries was diagnosed in every prisoner patient in the study group. Due to the lack of the necessary resources in the medical institutions of the SIZO, it is impossible to give a full assessment of the prevalence and intensity of various dental diseases among prisoners in comparison with those at large. In this regard, the results of our research should make it possible to develop a program to optimize dental care in the system of the Federal Service for the Execution of Punishments, to contribute to an increase in the level of dental health among persons in penitentiary institutions.
OPISTORCHIASIS IN SOUTH-WEST ASIA: HISTORY, GEOGRAPHY, EPIDEMIOLOGY, AND SOCIOLOGY. TOURISM AND POPULATION MOVEMENT INCREASE THE RISK OF THAI LIVER FLUKE SPREADING IN RUSSIA
Authors: O.A. Baykova , N.N. Nikolaeva , E.G. Grishchenko , L.V. Nikolaeva
Published: September 2021

This review covers the incidence of opisthorchiasis caused by Opisthorchis viverrini in South-East Asia countries: Thailand, Laos, Cambodia, and Vietnam. We analyzed the history of Opisthorchiidae representative’s discovery and cultural aspects of opisthorchiasis in South-East Asia. The most prevalent cancer type in Thailand is cholangiocarcinoma that is caused by Opisthorchiidae invasion. These parasites are transmitted to humans through raw fish consumption. Sociological studies demonstrated that raw fish food is the part of national traditions and identity of South-East Asian people. Tourism and population movement lead to the spreading of “Asian” Opisthorchiidae in Russia. The high prevalence of Opisthorchis felineus invasion in Russia may both simplify or complicate the clinical recognition of “Asian” opisthorchiasis. Molecular and genetic characteristics of the parasites determine their adaptivity, medication resistance, and finally, the clinical manifestations of opisthorchiasis. It contributes to the further understanding of chronic opisthorchiasis treatment.
DEVELOPMENT OF A METHOD FOR QUANTITATIVE DETERMINATION OF THE AMOUNT OF FLAVONOIDS IN TRIPLEUROSPERMUM INODORUM’S FLOWERS
Authors: O.L. Blinova , A.A. Gileva , A.V. Hlebnikov , V.D. Belonogova , A.Y. Turyshev
Published: September 2021

Chamomilla recutita is used in scientific medicine. Tripleurospermum inodorum (L.) Sch. Bip. is widely spread among possible impurities of Chamomilla recutita (L.) Rauschert. This plant is perspective for establishment into scientific medicine but it can’t change Chamomilla recutita (L.) Rauschert.
Purpose of research: development of a method for the quantitative determination of the amount of flavonoids in terms of rutin in Tripleurospermum inodorum’s flowers using differential spectrophotometry.
Materials and methods. The samples prepared in different parts of Russia were used as objects of research. (2017 – 2020). Spectral studies were carried out in the wavelength range of 350-430 nm with a step of 1 nm using a spectrophotometer SF-2000.
Results. To determine the analytical wavelength, the UV spectra of alcohol extraction of Tripleurospermum inodorum’s flowers were studied. Maximum of absorption was noticed at wavelength 370 nm. The differential spectrum of the same extraction with an aluminum chloride solution of 2% in 96% alcohol has a maximum at a length of 410±2 nm, which coincides with the maximum of the Standard Sample (SS) of rutin. The largest number of flavonoids is extracted by 70% alcohol. The maximum optical density and the highest output of the number of flavonoids from the raw material is observed at a degree of grinding of 2 mm with a single extraction for 60 minutes. In the conditions of complexation, the optimal ratio of the volume of the test solution and aluminum chloride with a solution of 2% in 96% alcohol is the ratio of 1:1. The stability of the complex with an aluminum chloride solution of 2% in 96% alcohol is observed in 40 minutes after the start of the reaction and retains it for 30 minutes.
Findings. The method is developed and the parameters of the quantitative determination of the amount of flavonoids in Tripleurospermum inodorum flores are determined in terms of rutin using differential spectrophotometry.
EXPERIENCE OF SUCCESSFUL REHABILITATION AFTER SPONTANEOUS ABORTION
Authors: O.B. Kalinkina , M.S. Amosov
Published: September 2021

The state of health of the child begins to form in the prenatal period and is determined by both the health of the parents and the conditions of pregnancy. In accordance with the WHO recommendations, it is possible to reduce reproductive failures by consulting women of reproductive age even before conception — at the pre-pregnancy stage, with measures aimed at reducing miscarriage and premature birth, as well as complications during pregnancy. According to the Russian clinical protocols for the management of patients after spontaneous termination of pregnancy in the early stages, a dose of folic acid 400 mcg is adequate for the prevention of neural tube defects and other fetal malformations, which often lead to early spontaneous pathological abortions. Folate is involved in the synthesis of DNA and prevents its changes by methylation, which is extremely important in rapidly dividing cells, which is characteristic of pregnancy. This is the basis for reducing the risk of miscarriage and premature birth, contributing to the normalization of the process of ovum nidation and placentation, as well as reducing the complications of gestation, the frequency of malformations in children. The purpose of this study is to prove by the example of a clinical case study that the inclusion of the active form of folate in pre-gravidar preparation is an effective way of rehabilitation after spontaneous abortion. Folate deficiency can lead to a state of hyperhomocysteinemia, leading to increased microthrombosis and changes in microcirculation, which leads to implantation defects and fetoplacental disorders. These processes may underlie the pathogenesis of miscarriage in early gestation, as well as the formation of chronic placental insufficiency and fetal growth retardation in the second half of pregnancy. Folate deficiency may be the cause of reproductive failures that are not related to other causes that cause spontaneous termination of pregnancy, as may have occurred in the clinical case we are studying.
THE SIGNIFICANCE OF THE CONTENT OF LOW AND MEDIUM MOLECULAR WEIGHT SUBSTANCES AND OLIGOPEPTIDES IN THE PATHOGENESIS OF VARICELLA
Authors: M.M. Margity , M.Y. Marzhokhova , S.B. Hadzegova
Published: September 2021

Endogenous intoxication syndrome is an important link in the pathogenesis of many infectious diseases. The role of low and medium molecular weight substances and oligopeptides acting as indicators of endogenous intoxication syndrome in the pathogenesis of varicella was studied, depending on the period of the disease, the severity of the course and the presence of complications. Based on this goal, 125 patients with varicella aged 18 to 49 years were examined. Determination of the content of substances of low and medium molecular weight in biological body fluids (blood plasma, red blood cells and urine) was carried out by the method of M. Ya.Malakhova (1995) on a spectrophotometer SF-46. The Lowru (1951) method was used to determine the level of oligopeptides in body fluids. The maximum level of substances of low and medium molecular weight was observed in patients with a complicated course of varicella during the height of the disease, as well as in patients with a severe course of the disease during the height. When determining the oligopeptides, the highest values were also obtained at the height of the disease in the severe course, as well as in the complicated course at admission. During the examination, the dependence of the studied indicators on the period of the disease, the severity, as well as the presence of complications was revealed. Thus, the most pronounced changes in the level of low and medium molecular weight substances and oligopeptides were observed in severe, and the least – in the mild course of varicella in all the studied media. In patients with developed complications, the disease was more severe, while the changes in the studied parameters were more pronounced.
THE IMPORTANCE OF SOCIAL AND HYGIENIC RESEARCH METHODS IN THE DISSERTATION WORK ON THE SPECIALTY "PUBLIC HEALTH AND HEALTHCARE".
Authors: M.V. Lebedev , K.I. Kerimova , I.Yu. Zakharova
Published: September 2021

This article presents the most well-known research methods that have been applied in practice, which make it possible to assess the state and indicators of public health and health care. The above methods contribute to obtaining the necessary data on the current activities of the subjects of the health care system and assessing the health and quality of life of the population. Modern medical science is characterized by an increase in the number of ongoing scientific research. Research is a necessary component of dissertation work, only they introduce new information into the health care system, allow one to acquire new skills, and contribute to the development of new technologies. The research results are certainly of interest to both healthcare professionals and patients. The requirements for the methodology of scientific research and the quality of the data provided by the researcher are becoming unambiguously more stringent. The implementation and implementation of scientific research in the field of medicine is associated with the need and obligation to comply with various standards and regulations. The published data must be scientifically new and presented in accordance with international standards. Undoubtedly, a certain role is played by the competent presentation of research and analysis methods, which allow the researcher and specialists studying the research data to correctly interpret the data obtained and put them into practice. Thus, selective planning of prospective research in the field of public health and health care, correct formulation of goals and objectives, concretization of research design, definition of modern research methodology and data analysis are the basis of its effectiveness. The use of a set of interacting medical and sociological research methods, focused on the result, contributes to the achievement of the set goals at the proper level.
THE DEVELOPMENT OF ANTI-SCAR OLEOGEL COMPOSITION WITH PARALITHODES CAMTSCHATICA COLLAGENASE
Authors: A.V. Mayorova , B.B. Sysuev
Published: September 2021

The collagenase enzyme proteolytic complex used in a gel form will be an alternative to invasive methods and electrophoresis, requiring medical personnel and special equipment. Taking into account the instability of proteolytic enzymes in the aquatic phase, the use of organogel as the collagenase basis makes it possible to create a stable and convenient dosage form for the scar treatment. This study’s aim was the composition of an anti-scar organogel based on Paralithodes camtschatica collagenase development. Aerosil proposed as a thickener. Various technological studies (external signs assessment, distribution on the skin, smearing, pH, proteolytic activity, stability, rheological properties) of gels samples based on lipophilic solvents: dimethicone, cyclomethicone, liquid paraffin, propylene glycol, capril/caprilic triglycerides, were carried out to select the optimal gel-forming agents. The proteolytic activity of the gel with collagenase manifested up to 24 hours, so, it may be used for stabilization. The composition of the components of the dispersion medium, which has acceptable sensory properties for the continuity of treatment, selected. It characterized by thermo- and colloidal stability, acceptable rheological properties. The oleogel on the combination of capril/caprilic triglycerides and dimethicone as a dispersion and aerosil as a thickener was justified, which may be recommended as an anti-scar agent for further research.