bluuebunny/crossref_metadata_2025 huggingface dataset:
Fragment-based Drug Designing to Develop New Hits Against Multiple Receptors of Coronavirus
Authors: Benny Sonu , Biju Namitha , Vishnu V. R , Kumar Sunil , George Ginson , P Aneesh T
Published: February 2023

Purpose COVID-19 pandemic has become worse with the difficulty of tracing the virus or phase of the coronaviral cycle inside the host, the failure of currently employed drugs over a vast population and the evolution of newer multiple strains. This work aimed to investigate and design novel molecules that can tackle coronaviral disease more effectively Methods The study was initiated with a drug repurposing approach to screen the existing drugs against multiple receptors of the initial strain, alpha coronavirus, through various in-silico analyses. The best hits were selected on their binding affinity towards most targets and their physicochemical properties. Top hits were assessed for their efficiency against multiple coronavirus strains, such as delta and Omicron and their Ligand-protein complexation stability through molecular dynamics study. They were further fragmented and subjected to fragment-based drug designing (FBDD) to give rise to novel molecules. Results Amentoflavone, Lopinavir and Teniposide were identified as the most effective ligands against multiple receptors of the corona viral protein through the drug repurposing studies. These drugs were fragmented, linked together in multiple fashions through the process of clustering and growing to give rise to some newly designed drugs. The novel compounds exhibited more affinity towards the multiple strains of coronavirus than their parent counterparts did. Conclusion Overall, the study resulted in the generation of novel moieties with promising activity towards the multiple strains of coronavirus through FBDD initiated through a multi-targeting anti-covid drug repurposing study.
Distribution modelling of brown trout Salmo trutta for predicting habitat expansion in the Himalayas, India
Authors: Singh Atul K , Srivast Sharad C
Published: February 2023

Suitable habitat conditions for brown trout Salmo trutta, were modeled with MaxEnt software using sets of bioclimatic variables for current conditions and topographic variables for landscape and drainage conditions. Our model revealed that the most favorable conditions for brown trout were present in the Jammu & Kashmir, Himachal Pradesh, Uttarakhand, Arunachal and Sikkim regions of the Himalayas. We analyzed 83 parameters using the MaxEnt model for Salmo trutta which showed that it was an outstanding prediction model as area under curve (AUC) was 0.947 and was very much close to 1. The major climatic factors for expansion of Salmo trutta distribution revealed that contribution of the corresponding altitudinal variable (GMTED_DEM) was 55.9%, Precipitation of Driest Quarter (Bio_17) was 22.5%, and Precipitation Seasonality (Bio_15) was 12.5% and they were the drivers of further distribution expansion of Salmo trutta in the Himalayan states. Future projections revealed significant changes in the probability distribution of the fish, where they can be of interest developing organized angling in the Himalayan regions and can contribute to the prioritization of angling and restoration sites.
Antiplatelet and Anticoagulation Therapy and the Risk of Pituitary Apoplexy in Pituitary Adenoma Patients
Authors: Ciavarra Bronson , McIntyre Timothy , Kole Matthew J. , Li Wen , Yao William , Guttenberg Katie B. , Blackburn Spiros L.
Published: February 2023

Purpose
Pituitary apoplexy can be a life threatening and vision compromising event. Antiplatelet and anticoagulation use has been reported as a contributing factor in pituitary apoplexy (PA). Utilizing one of the largest cohorts in the literature, this study aims to determine the risk of PA in patients on antiplatelet/anticoagulation (AP/AC) therapy.
Methods
A single center, retrospective study was conducted on 342 pituitary adenoma patients, of which 77 patients presented with PA (23%). Several potential risk factors for PA were assessed, including: patient demographics, tumor characteristics, pre-operative hormone replacement, neurologic deficits, coagulation studies, platelet count, and AP/AC therapy.
Results
Comparing patients with and without apoplexy, there was no significant difference in the proportion of patients taking aspirin (45 no apoplexy vs. 10 apoplexy; p = 0.5), clopidogrel (10 no apoplexy vs. 4 apoplexy; p = 0.5), and anticoagulation (7 no apoplexy vs. 3 apoplexy; p = 0.7). However, male sex (p-value < 0.001) was a predictor for apoplexy while pre-operative hormone treatment was a protective factor from apoplexy (p-value < 0.001). A non-clinical difference in INR was also noted as a predictor for apoplexy (no apoplexy: 1.01 ± 0.09, apoplexy: 1.07 ± 0.15; p < 0.001).
Conclusions
Although pituitary tumors have a high risk for spontaneous hemorrhage, the use of aspirin is not a risk for hemorrhage. Our study did not find an increased risk of apoplexy with clopidogrel or anticoagulation, but further investigation is needed with a larger cohort. Confirming other reports, male sex is associated with an increased risk for PA.
The effect of real-world follow up delay between planned intravitreal anti-VEGF treatments for neovascular age- related macular degeneration on retinal thickness
Authors: Corbett James Walter , Watts Andrew , de Ribot Francesc March
Published: February 2023

Purpose: To study the impact of real-world follow-up delay on anatomical outcomes for age-related macular degeneration (AMD) treated with intravitreal injection.
Methods: A retrospective, sequential, observational cohort analysis of the Whangārei Hospital retinal clinic was conducted between Aug 2021 – Dec 2021. Planned follow-up time on treat and extend (T&E) protocol was compared with actual follow-up injection time. OCT Central Subfield Thickness (CST) measurements were compared between treatment reviews for each patient.
Results: The mean delay from planned injection for patients receiving intravitreal injection (n=709) was 6.51 days [SD = 13.88]. Eyes that received an intravitreal injection within 7 days of their planned treatment date prior to clinical review (n=209) had a mean reduction of their CST [-5.74mm ± 2.84mm]. Eyes that received treatment later than 7 days from their planned treatment date prior to clinical review (n=152) had a mean increase in the CST [9.03mm ± 4.33mm]. We established a time-dependent correlation between increased delay (in weeks) and CST.
Conclusion: A delay greater than 7 days from planned injection was associated with a statistically significant increase in the CST in patients with AMD. It also indicates the importance of adherence to recommended follow-up timeframes when following T&E protocol.
Numerical analysis of glass edge chipping by impact loading
Authors: Hirobe Sayako , Sato Yosuke , Takato Yoichi , Oguni Kenji
Published: February 2023

This study presents numerical analyses for edge chipping by impact loading. As a numerical analysis method, we extend Particle Discretization Scheme Finite Element Method (PDS-FEM) developed by the authors to be able to simulate fracture due to impact loading. We performed simulations targeting edge chipping of soda-lime glass by impact of rigid iron sphere and examined the crack morphology while varying the diameter of the impactor, the impact velocity, and the impact distance. The proposed method successfully simulates the 3D complex crack pattern on edge chipping such as Hertzian cone crack and conchoidal chip scar. The method also reproduces the change of crack morphologies depending on the impact force and the impact distance. Also, a series of numerical analyses are presented to reveal the effect of the impactor geometry on the chip dimensions. The height of chip is independent of the impactor geometry while the width of chip depends on it. According to the agreement with experimental results, it is confirmed that the proposed method is capable of realizing edge chipping due to impact loading.
Ethanol extract of Camphor tree bark as green corrosion inhibitor of LCS in 0.5 M H2SO4 with and without synergistic effect
Authors: Nemr Ahmed El , Elhebshi Abdualah , Ashour Ibrahim , El-Deab Mohamed S. , Barghout Nehal A. , Ragab Safaa
Published: February 2023

This work tested the ethanol extract of Camphor tree Cinnamomum camphora bark (CTBEE) as a green corrosion inhibitor of low carbon steel (LCS) in 0.5 M H2SO4 with and without the synergistic effect of 0.1 M NaCl or 800 ppm of KI. The corrosion protection of LCS was significantly increased in the presence of CTBEE-KI and CBWE-NaCl blends compared to CTBEE alone, according to data performed by electrochemical impedance spectroscopy (EIS) and electrochemical polarization (EP) analyses. The formation of a film by the blends blocks the LCS surface area preventing corrosive gradients to reach its surface. Inhibition efficiency (IE%) of 81 and 89% were obtained in the presence of 800 ppm CTBEE-0.1 M NaCl and CTBEE-800 ppm KI, respectively, compared to IE of 65% in the presence of 800 ppm CTBEE only. A maximum IE% of 89 and 97% were reached after 72 hours of immersion in the presence of CTBEE-NaCl and CTBEE-KI, respectively. Potentiodynamic experiments indicate that the blends act as mixed-type inhibitors. Inhibition efficiency of CTBEE, CTBEE-KI and CTBEE-NaCl remained effectively high with testing period of immersion time which proved the good stability of CTBEE in the corrosive acidic media.
CD5L is a Potential Hepatocellular Carcinoma Biomarker for Clinical prognostic and immunotherapy
Authors: Zhang Baojian , Ma Xiao , Lin Zhenhua , Liu Yanqun
Published: February 2023

CD5L acts as an important regulator of inflammation by suppressing the immune response and blocking the secretion of pro-inflammatory cytokines. However, systematic evaluations of CD5L-related genes in human cancers are lacking, particularly in their predictive role in hepatocellular carcinoma progression. Here, we obtained data from the Tumor Genome Atlas (TCGA), an open database website, to evaluate CD5L mRNA expression in HCC patients to identify CD5L-related HCC pathogenesis pathways. According to the Timer database, CD5L has significant protein interaction with FASN, CD163, STAB2 and LILRB5. KaplanMeier survival analysis evaluated the survival prognostic relationship between CD5L in liver cancer and hepatitis virus, respectively. CD5L enrichment was analyzed by KEGG, Biological processes, Molecular functions and Cellular components. CD5L expression was low in tumor tissues and increased in neighboring tissues, showing tumor inhibitory effect. CD5L is closely related to clinicopathology and its expression is reduced in hepatitis patients. TP53 mutations with low CD5L expression are more frequent in HCC. The high expression of CD5L triggered the immune response and promoted the infiltration of CD4 + T cells, CD8 + T cells, Macrophages, Tfh and other cells, showing a significant positive correlation. We comprehensively evaluated the anti-tumor role of CD5L biomarkers in HCC, and CD5L may be a new target for tumor immunotherapy.
Gender differences in commuting in dual-earner households
Authors: Echeverría Lucía , Gimenez-Nadal J. Ignacio , Molina José Alberto
Published: February 2023

Prior literature analyzing gender differences in commuting has reported that men commute longer distance/time than do women, and one explanation for this gender gap is based on household responsibilities falling on women. But most of the literature examining gender differences in commuting has not considered the interdependence that exists between the members of couples. We analyze gender differences in commuting time, and we take into account the inter-relatedness of decisions, estimating Seemingly Unrelated Regressions (SUR) on commuting time and mode of transport (private, public, and active transport) for dual-earner couples in Spain, Italy, Korea, and the United Kingdom. Our results indicate that the number of children is significantly related to shorter female commuting times in Spain, Italy, and the UK, with no associations found for men, while in Korea there is a reduction in both male and female commuting times. Additionally, the presence of children significantly increases (decreases) the proportion of commuting time done by private (public) transport, but results differ significantly by gender, number of children, and country. Our evidence indicates that couples’ decisions on commuting are complementary, which may shed light on the relationship in commuting that theoretical models should address.
JEL Classification: R40 - J22 - O57 - D19
Impact of numerous larval diets on biology of pink bollworm Pectinophora gossypiella (Lepidoptera: Gelechiidae) under laboratory conditions
Authors: Akhtar Shamim , Arif Muhammad Jalal , Gogi Muhammad Dildar , haq Imran Ul
Published: February 2023

Pink bollworm, Pectinophora gossypiella (Saunders) (Lepidoptera: Gelechiidae) has become a potential pest of cotton by causing substantial yield losses around the world including Pakistan. As a limited past research investigations on dietary aspect of P. gossypiella are available, the present study was conducted. A number of biological aspects of P. gossypiella were studied by rearing on different larval diets that were prepared using indigenous elements. The standard/laboratory diet comprised of wheat germ-meal 34.5, casein 30.0, agar-agar 20.0, sucrose 10.0, brewer’s yeast 5.0, α-cellulose 1.0, potassium-sorbate1.5, niplagin 0.5, decavitamin 0.01, choline-chloride 0.06, maize-oil 3.30, honey 2.0, and water 730.0 g/ml/kg. Alternative natural diets cotton, okra seed sprouts, cotton bolls and okra fruit was also included in the study. Among artificial diets, larval development was completed in 19.68±0.05 days with weight of 20.18±0.20 mg at fourth instar fed on cottonseed meal-based diet instead of wheat germ-meal based diet. On same diet, 84.00±4.00%, 17.24±0.03 mg and 7.76±0.06 days was recorded as pupation period, pupal weight and pupal duration, respectively. Adult emergence, 76.00±1.00% was recorded from pupae collected larvae those raised on cottonseed meal based diet. These adults (males and females) lived for 40.25±0.10 and 44.34±0.11 days, respectively. Female moths deposited 21.28±0.04 eggs/day with 65.78±0.14% viability. The larval mortality was 37.20±1.36% was recorded while remaining (62.80±1.36%) larval population successfully pupated. Mal-pupation 12.00±1.41% was also documented. This research is of novel nature as it provides concise, objective oriented and practical interventions for economic and successful rearing of P. gossypiella.
HIV-1 interaction with an O-glycan-specific bacterial lectin enhances virus infectivity and cell-to-cell viral transfer
Authors: Heindel Daniel , Acosta Dania Figueroa , Goff Marisa , Jan Muzafar , Wang Xiao-Hong , Petrova Mariya , Chan Kun-Wei , Kong Xiang-Peng , Chen Benjamin , Mahal Lara , Bensing Barbara , Hioe Catarina
Published: February 2023

While bacterial dysbiosis has been associated with increased HIV-1 transmission risk, little is known about direct associations between HIV-1 and bacteria. This study evaluated HIV-1 interactions with bacteria through glycan-binding lectins that affect virus infectivity. The Streptococcal Siglec-like lectin SLBR-N, which is part of the fimbriae shrouding the bacteria surface and recognizes α2,3 sialyated O-linked glycans, was noted for the ability to enhance HIV-1 infectivity in the context of cell-free infection and cell-to-cell transfer. SLBR-N was demonstrated to capture HIV-1 virions, bind to O-glycans on HIV-1 Env, and augment CD4 binding to Env. Other SLBRs recognizing distinct O-glycans also enhanced HIV-1 infectivity, albeit to lower extents, whereas N-glycan-binding bacterial lectins FimH and Msl had no effect. Enhancing effects were recapitulated with O-glycan-binding plant lectins. Hence, this study highlights the potential contribution of O-glycans in promoting HIV-1 infection through the exploitation of O-glycan-binding lectins from commensal bacteria at the mucosa.
The Accuracy of Ultrasound-guided Fine-needle Aspiration and Core Needle Biopsy in Diagnosing Axillary Lymph Nodes in Women With Breast Cancer: a Systematic Review and Meta-Analysis
Authors: Zheng Haining , Zhao Rui , Wang Wei , Liu Xiaona , Wang Xiaoqing , Wen Chaoyang , Ren Yubo
Published: February 2023

Background: This study performed an overall assessment of the accuracy of ultrasound-guided fine-needle aspiration (FNA) and core needle biopsy (CNB) for detecting axillary lymph nodes in women with breast cancer based on qualified studies.Methods: Eligible studies and pertinent literature resources were identified on Cochrane, PubMed, Embase, CNKI, VIP, and Wanfang databases through searching key words or terms. The latest study was published in the March 2020. The eligible publications contained cohort and cross-sectional researches. All the publications obtained were tested for heterogeneity, and corresponding effect models were used to calculate amalgamative values of sensitivity, specificity and diagnostic odds ratio (DOR). Analysis of summary receiver operating characteristic (SROC) was performed on suspicious axillary lymph nodes.Results: A total of 22 studies involving 3548 patients were included to explore the accuracy of FNA in identifying axillary lymph nodes in women with breast cancer. 11 studies involving 758 patients were included to explore the accuracy of CNB in identifying axillary lymph nodes in women with breast cancer. The accuracy of FNA in identifying suspicious axillary lymph nodes was specifically as follows: overall sensitivity was 79% (95%CI: 73%-84%), global specificity was 96% (95%CI: 92%-98%), overall positive likelihood ratio was 18.55 (95% CI: 10.53-32.69), overall negative likelihood ratio was 0.22 (95% CI: 0.17-0.28), the overall DOR was 71.68 (95%CI: 37.19-138.12), and the acreage under the SROC was (AUC = 0.94; 95% CI: 0.92-0.96). The accuracy of CNB in identifying suspicious axillary lymph nodes was specifically as follows: overall sensitivity was 85% (95%CI: 81%-89%), global specificity was 93% (95%CI: 87%-96%), overall positive likelihood ratio was 11.88 (95% CI: 6.56-21.50), overall negative likelihood ratio was 0.16 (95% CI: 0.12-0.21), the overall DOR was 66.83 (95%CI: 33.28-134.21), and the acreage under the SROC was (AUC = 0.96; 95% CI: 0.94-0.97).Conclusions: The results indicated that both FNA and CNB had high accuracy for suspicious axillary lymph nodes.
Cathodoluminescence of iron oxides and oxyhydroxides
Authors: Galili Nir , Kaplan-Ashiri Ifat , Halevy Itay
Published: February 2023

Iron oxides and oxyhydroxides show promise as superconductor materials and as repositories of paleo-environmental information. However, there are no microscale non-destructive analytical techniques to characterize their combined mineralogy, chemical composition, and crystal properties. We address this by developing cathodoluminescence mounted on a scanning electron microscope (SEM-CL) as an in situ, non-destructive method for the crystallographic and petrographic study of iron oxides and oxyhydroxides. We show that goethite, hematite, and magnetite display different SEM-CL spectra, which may be used for mineral identification. We further show that different formation pH, manganese substitution for iron in goethite and hematite, and titanium substitution for iron in magnetite cause shifts in the SEM-CL spectra of these minerals. These spectral shifts are not always detectable as a change in the emission color but are easily discernable by quantitative analysis of the spectra. Together with subtle but observable variations in the SEM-CL spectra of natural goethite and hematite, we suggest that these dependences of the SEM-CL spectra on pH and chemical composition may be used as a means of identifying multiple episodes of mineralization and recrystallization. We apply the newly developed SEM-CL methods to two polished sections of natural samples and show that quantitative analysis of the spectra obtained allows the identification of differences between varieties of the same mineral that are not observable by other means. Like the application of SEM-CL to geologic samples in this study, we suggest that this approach may be used to explore the in situ chemistry and crystallinity of various natural and manufactured iron oxides and oxyhydroxides.
GINGIVAL WOUND HEALING RESPONSE FOLLOWING PLACEMENT OF A LIGHT CURE DRESSING WITH AND WITHOUT BLUE M®GEL AFTER GINGIVAL DEPIGMENTATION. A RANDOMIZED SPLIT MOUTH STUDY
Authors: Sethi Lakshay , Chopra Rahul , Sharma Prashansa , Malhotra Sumit , Idnani Simran , Kabra Ritika
Published: February 2023

Background: In todays world pigmentation of gingiva not just has an impact on esthetics but also creates psychological negativity.Esthetic awareness of dental patients has extended to include requests of gingival color modification.Different treatment modalities which have been reported include bur abrasion, scraping, partial thickness flap, cryotherapy, electrosurgery. However, pain and healing are the two drawbacks associated with the post operative discomfort after the procedure which can be catered well with use of a newly developed oxygen releasing gel ie. Blue MÂ® Gel and light cure periodontal dressing. Method: A total of 10 patients randomly divided into two groups were selected for this randomized split mouth study. Gingival depigmentation using a scalpel were performed followed by Placement of a light cure dressing (BarricaidÂ®) in10 anterior sextants after gingival depigmentation in Group â… and Application of an oxygen releasing oral gel (BlueMÂ®) before placement of a light cure dressing (BarricaidÂ®) in Group â…¡. Wound Healing Index at day 7, VAS Score (Pain) at day 3 and GI & PI at day 7 &14 after the gingival depigmentation were evaluated for both the groups. Results:There was no significant difference in clinical parameters recorded at various time intervals between both the groups. Conclusion: The use of Blue MÂ® Gel underneath light cure periodontal dressing did not enhance the healing following Gingival depigmentation.
NUTRIENT COMPOSITION OF YELLOW MALAY DWARF COCONUT TREE (COCOS NUCIFERA L.) LEAF USING GREEN MANURES
Authors:   Campo Experimental Chetumal, km 25 carreteraChetumal -Cancun s/n. Xul-ha, Quintana Roo., Enrique Sosa Rubio Edgar , Cortazar Rios Matilde ,   Campo Experimental Chetumal, km 25 carreteraChetumal -Cancun s/n. Xul-ha, Quintana Roo., Jose Herrera Cool Gilbert ,   Campo Experimental Chetumal, km 25 carreteraChetumal -Cancun s/n. Xul-ha, Quintana Roo., Humberto Ramirez Silva Jorge ,   Centro de Investigacion Regional Sureste (CIRSE) del INIFAP. Calle 6 Num. 398 x 13, Avenida Correa Racho. Col. DiazOrdaz, C.P. 97130. Merida YucatÃ¡n, Mexico., Del Carmen Zavaleta Cordoba Maria ,   Campo Experimental Chetumal, km 25 carreteraChetumal -Cancun s/n. Xul-ha, Quintana Roo., Montoya Reyes Francisco ,   Campo Experimental Chetumal, km 25 carreteraChetumal -Cancun s/n. Xul-ha, Quintana Roo.
Published: February 2023

The objective of the study was to evaluate the effect of different green manures on the concentration of macro and micronutrients present in the leaves of the Dwarf Malaysian Yellow coconut palm. The experiment was carried out from April 2018 to December 2020, at the INIFAP Chetumal Experimental Field. A randomized block experimental design was used, with four replications for eight treatments: T1 without fertilization, T2 chemical fertilization, T3 partial chemical fertilization, T4 Tithoniadiversifolia (Td), T5 Clitoriaternatea (Ct), T6 Leucaenaleucocephala(Ll), T7 Canavaliaensiformis (Ce) and T8 Gliricidiasepium (Gs). The sowing of the green manures was carried out between the rows of coconut palms, in two separate rows one meter apart and one meter between plants. The concentration of macro (N, P, K, Ca, and Mg) and micronutrients (Cl, Na) in leaf number 9 was evaluated. The results indicate that macro and micronutrients were not influenced by the treatments fertilized with N, P and K. It was observed that treatments T6 Coco+ C. ensiformis, T7 Coco+ T. diversifolia and T8 Coco+ C. ternatea influenced the evaluation obtained in leaves due to values obtained were considered optimal. Concentrations of N, P, Ca and Mg in the leaf decreased, Cu and Cl were higher than the critical levels, after two years of starting the work.
EVALUATION OF SEMINAL FRUCTOSE AND CITRIC ACID LEVELS IN INFERTILE MALES AND ITS CORRELATION WITH BODY MASS INDEX (BMI) IN POPULATION OF JAMMU AND KASHMIR
Authors: Debnath Sumit , Gupta Kiran , Sharma Rahul , Siddique Saqib
Published: February 2023

Introduction:30-35% of total population in Jammu and Kashmir reportedly has infertility problem which can be related to many factors. Overweight and obesity is one such factor which have a negative effect on fertility. It is generally assumed that obese patients have higher fat content in semen samples and that higher BMI value alters the level of reproductive hormones. Materials and methods: 150subjects (100 infertile as test and 50 fertile subjects as controls) were taken after taking proper consent. Sample was collected by the criteria laid down by WHO 2010. Results:In this study, the sperm count was found as 56.57 Â± 8.47 in fertile and 15.8 Â± 2.85 in infertile subjects. The fructose levels for controls and test were found out to be 108.29Â±2.97 and 92.68Â±3.75. And the citric acid levels are 36.70 Â±1.65 and 42.16Â±1.22 in control and test respectively. Conclusion: In our study conducted in the population of Jammu and Kashmir, it has been found that increase BMI value has a significant relation with infertility.
ANALYSIS OF SUPPLY CHAIN SOCIAL SUSTAINABILITY IN HOTEL INDUSTRY
Authors:   M.S Ramaiah Institute of Management, Bangalore., R. Mallieswari , R. Jeevitha ,   M.S Ramaiah Institute of Management, Bangalore., Mishra Niharika ,   M.S Ramaiah Institute of Management, Bangalore.
Published: February 2023

Social sustainability is a beneficial approach to tracking and comprehending the effects of business on representatives, value chain employees, consumers, and nearby networks. Organizations that promote social sustainability value their relationships with people, networks, and communities. Social responsibility has proven to be critical for their core business operations, and they understand how their activities affect people. Collaboration has a human cost. A socially responsible organisation would value the safety and security of its employees in a specific industry. It will not jeopardise the health and safety of its employees by requiring them to work in an unsafe structure. This study focuses on the social sustainability in the hotel industry. According to the studys findings, many employees do not receive their pay cheques on time. Some hotels should ensure that their employees work in a secure environment. People have also agreed that they are capable of being socially sustainable. They have stated that social sustainability in the industry is extremely important to their company. Proper working conditions, as well as providing employees with health insurance, will motivate and encourage them. As social sustainability is important in all industries because it aids in long-term development, having social sustainability in the hotel supply chain can help the organisation reach great heights, as there is a saying that treat employees well they are the ones who get you the business.
THE EFFECT OF SPIRITUAL LEADERSHIP AND ORGANIZATIONAL CULTURE ON EMPLOYEE PERFORMANCE WITH ORGANIZATIONAL COMMITMENT AS A MEDIATOR
Authors:   Warmadewa University Faculty of Economics and Business., Wayan Sana I. , Udayana Putra Ida Bagus ,   Warmadewa University Faculty of Economics and Business., Made Suniasta Amerta I. ,   Warmadewa University Faculty of Economics and Business.
Published: February 2023

This study aims to analyze the effect of spiritual leadership and organizational culture on employee performance with organizational commitment as a mediating variable. The object of this research is Koperasi in Denpasar City which have the best performance in four sub-districts. The sample in this study was determined by purposive sampling method. The respondents in this study were all employees of the four selected cooperatives with a total of 63 people. The data collection method is a survey method with a questionnaire. The analysis technique used is inferential analysis with Partial Least Square (PLS). The results showed that spiritual leadership has a positive and significant effect on employee performance and has a positive significant effect on organizational commitment. Organizational culture has no significant effect on employee performance but has a significant effect on organizational commitment. Organizational commitment has a positive and significant effect on employee performance. In the mediation relationship, it was found that organizational commitment as a partial mediation on the effect of spiritual leadership on employee performance but organizational commitment is able to perfectly mediate the effect of organizational culture on employee performance.
EMPIRICAL ANALYSIS OF THE CONTRIBUTION OF AGRICULTURE TO NATIONAL ECONOMIC DEVELOPMENT
Authors:   Independent Researcher Tashkent State Agrarian University., Azizxkhuja Makhmudov
Published: February 2023

The article is devoted to econometric models of increasing agricultures contribution to the national economys development through state support of investments. Based on the econometric equation of the ARDL model, a forecast for the study was developed using the ARIMA model.
CHALLENGES, CHANCES & CHANGES WITH OBSTETRIC CO- MORBIDITIES IN PREGNANT WOMEN WITH COVID-19
Authors:   PostGraduate, Department of Obstetrics & Gynaecology, Andhra Medical College, Visakhaptnam, Andhra Pradesh, India., Divya Yegireddi , Kavitha Ampolu ,   Assistant Professor, Department of Obstetrics & Gynaecology, Andhra Medical College, Visakhaptnam, Andhra Pradesh, India., Sailaja Chodavarapu ,   Former Assistant Professor, Department of Obstetrics & Gynaecology, Andhra Medical College, Visakhaptnam, Andhra Pradesh, India., Soumini Gangaraju ,   Professor, Department of Obstetrics & Gynaecology, Andhra Medical College, Visakhaptnam, Andhra Pradesh, India.
Published: February 2023

Introduction:Covid 19 pandemic had a significant impact on peoples lives all over the world, and pregnant women are one of the most vulnerable groups of population more so with obstetric comorbidities. Aim: To study the association of obstetrical co-morbid conditions and the course of covid 19 infection in pregnant women. Methods: It is a cross-sectional, quantitative observational study carried out atKingGeorgeHospital,Andhra Medical College,Visakhapatnam. Study participants were women diagnosed with covid 19 infection who were admitted at CSR block, King George Hospital during the period April 2021-October 2021. ICU admissions, maternal mortality in women with covid 19 infection, and their association with obstetrical co morbidities were studied. Results:Among 392 hospitalized pregnant women with covid19 diagnosis,122 were asymptomatic at the time of admission.Majority of patients were in age group between 21-30yrs .60 women had obstetric comorbidities like preeclampsia, obesity, and GDM.. Preeclampsia accounted for6.1% of the population in the study,GDM for 3.6%, and obesity for 5.6%.Of all individuals, 48 (12.2%)were admitted in Intensive Care Unit,35 women required invasive mechanical ventilation and 24 deaths were reported which accounts to 6.1%.Obesity was found to have a significant association with covid 19 morbidity and mortality in this study,where as no significant association was found with other obstetric comorbid conditions such as gestational diabetes and preeclampsia. Conclusions:Though all three comorbid conditions contributed to morbidity such as ICU admissions and deaths, obesity alone showed a statistically significant association with maternal morbidity and mortality.Identification of risk factors during hospitalisation is therefore crucial for directing preventative measures and initiate appropriate treatment.
STUDY OF THE ANTIOXIDANT POTENTIAL OF 3.4-DIHYDROXYBENZOIC AND GALLIC ACIDS EXTRACTED FROM HEDYSARUM NEGLECTUM
Authors: Bahtiyarova A.H. , Babich O.O. , Larina V.V.
Published: February 2023

Hedysarum neglectum is known for its useful properties, including antioxidant activity.
During the study, the optimal parameters of extraction of this plant were selected and the
metabolomic composition of its extracts was investigated. Selection of parameters for the release
of individual biologically active substances has been selected. Gallic and 3.4-dihydroxybenzoic
acid were obtained. They showed high antioxidant activity.
DETERMINATION OF THE POLYPHENOLS CONTENT AND ANTIOXIDANT ACTIVITY IN KOMBUCHA-BASED BEVERAGES WITH THE ADDITION OF EXTRACTS OF FRAGRANT HERBS OF VARIOUS CONCENTRATIONS
Authors: Petrova A. , Izgarysheva Natalia V , Belyaeva Oksana , Loseva Anna
Published: February 2023

Objective: to identify the effect of various concentrations fragrant herbs extracts additives
of on the content of polyphenols and antioxidant activity of the tea mushroom-based drink
(kombucha)
ENCAPSULATED COLLAGEN HYDROLYSATE AS A COMPONENT OF FUNCTIONAL PRODUCTS
Authors: Ryabokoneva L. A. , Sergeeva Irina
Published: February 2023

Collagen is a biologically important component that carries a large functional load. At
the moment, there is a tendency to a reduced production of this protein in our body, so the
question of obtaining food forms of collagen is relevant. The process of assimilation biological
substances is accompanied by a high rate of nutrient release. The encapsulation process allows
you to prolong this process and protect the component with functional activity from the
aggressive stomach environment. An extract of woody greens obtained by water-alcohol
extraction was adopted as an encapsulated substance. The "core" of the capsule was collagen
hydrolysate obtained by alkaline hydrolysis from the skins of commercial fish.
FEATURES OF YEAST CULTIVATION IN CHEESE WHEY FOR BETAGALACTOSIDASES PRODUCTION
Authors: Ryabtseva Svetlana , Sazanova S. N. , Shpak Maria A , Tabakova Yu. A. , Semchenko A. A.
Published: February 2023

The results of a study of the growth patterns of kefir yeast, Kluyveromyces marxianus,
Candida kefir in cheese whey during separate and joint cultivation with Lactobacillus
acidophilus are presented. The maximum yield of yeast biomass was obtained after 3-7 days of
cultivation. L. acidophilus inhibits the reproduction of yeast.
THE CONTRIBUTION OF POLYMORPHIC VARIANTS OF DNA REPAIR GENES TO THE FORMATION OF INDIVIDUAL SENSITIVITY TO THE EFFECTS OF ADVERSE ENVIRONMENTAL FACTORS. LITERATURE REVIEW
Authors: Sokolova A. O.
Published: February 2023

This literature review is devoted to the study of the contribution of polymorphic variants of
DNA repair genes to the formation of individual sensitivity to environmental factors
SELECTION OF COMPONENTS FOR THE CREATION OF A COMPLEX CARRIER IN THE SORPTION IMMOBILIZATION OF TRACE ELEMENTS
Authors: Belokurova E. V. , Sargsyan M. A.
Published: February 2023

Objective: To search and select the most suitable dispersion media for adsorption
immobilization, effective as a complex carrier, with the possibility of their further application in the
food industry
PEPTIDES AS A FUNCTIONAL INGREDIENT FOR PREVENTIVE PRODUCTS
Authors: Tikhonov Sergey , Tikhonova Nataliya , Merzlyakova N. V. , Ozhgihina A. S.
Published: February 2023

Clinical studies indicate that products from cow colostrum are well tolerated by the
human body, non-toxic and safe for consumption. The aim of this study is to study the
antitumor properties of isolated individual peptides from corvine colostrum on the cell line of
rat glioblastoma C6. The study revealed that peptide R1 has antitumor activity, therefore it can
be used as a functional ingredient in food products.
EFFECT OF PERIOPERATIVE SUPPLEMENTAL ENTERAL NUTRITION IN CARDIAC SURGICAL PATIENTS
Authors: Belysheva O.A.
Published: February 2023

The study evaluated the results of treatment of cardiac surgery patients with the use of additional
enteral nutrition in the perioperative period.
DETERMINATION OF THE BIOLOGICAL ACTIVITY OF SHUNGITE
Authors: Shevchenko Tat'yana , Ustinova Yulia , Uzunov G. B.
Published: February 2023

Objective: to find an affordable and technically simple way to assess the biological
activity of shungite water.
shungite, yeast, biological activity, water, inhibition.
CHRONONUTRITIOLOGICAL FEATURES OF THE NUTRITIONAL STATUS DURING SHIFT WORK OF STUDENTS
Authors: Budkevich R.O. , Budkevich E.V. , Fedorcov N.M.
Published: February 2023

The purpose of this study was to evaluate anthropometric indicators, nutrient intake and the
around-the-clock nutrition structure in students with episodic shift work. The presence of shift work
experience was accompanied by an increase in BMI and the appearance of persons with the first degree
of obesity. There is an increase in the number of students with higher calorie intake and a lack of betacarotene and PUFA in the diet. Meals were shifted to a later time, the number of daytime and evening
meals was reduced with a significant increase in the number of late dinners and snacks. The detected
changes in the diet are a negative experience of the lifestyle of students and is a health risk factor.
INFLUENCE OF GENETIC FEATURES ON THE DEVELOPMENT OF ATHEROSCLEROSIS
Authors: Vesnina Anna
Published: February 2023

In the course of the work, it was found that a large number of genetic features affect the development of atherosclerosis (gene SNPs, telomere length, epigenetic factors, circadian rhythms). Studies of SNP genes, in particular those affecting lipid metabolism, predominate. Relatively new is the study of the relationship between chrononutrition and the development of metabolic diseases.
PERSONALIZED NUTRITION FOR THE PREVENTION OF ATHEROSCLEROSIS (ROLE OF GI MICROBIOTA)
Authors: Vesnina Anna , Chaplygina Olga , Prosekov Alexander
Published: February 2023

The microbiota of the gastrointestinal tract (GIT) plays an important role in maintaining the health of the host organism. It is known that the development of atherosclerosis is associated with the work of the microbiota of the gastrointestinal tract, the regulation of which is possible through nutrition, for example, through the systematic intake of individually selected probiotics.
THE USE OF PEPTIDES AND HYDROCOLLOIDS IN THE PRODUCTION OF FUNCTIONAL MEAT PRODUCTS
Authors: Voroshilin Roman , Baranova E. R. , Simon V. A. , Shlyapina K. A.
Published: February 2023

Objective: to evaluate the effect of the properties of hydrocolloids on food, to consider their functions in the food industry and the impact on the human body.
CERTAIN ASPECTS OF DEVELOPING PLANT-BASED FERMENTED BEVERAGES
Authors: Dolgolyuk Irina , Zagrebaylova A.V.
Published: February 2023

Objective: To analyze raw materials used for producing fermented beverages, to assess the possibility of using plant-based raw materials in order to regulate the properties of the finished product. To identify modern trends in the technology of obtaining non-alcoholic fermented beverages.
CREATION OF RUSSIAN HIGH-TECHNOLOGY MANUFACTURING OF LACTOSE AND LACTULOSE INTENDED FOR IMPORT SUBSTITUTION IN MEDICINE, VETERINARY, INFANT FOOD AND HEALTHY NUTRITION
Authors: Evdokimov Ivan , Lodygin Aleksei , Anisimov Georgi S
Published: February 2023

The Russian high-technology manufacturing of lactose of food and pharmaceutical grades is presented. Technology of prebiotic lactulose is being created using lactose as a raw material. The concept of lactose and its derivatives producing from various types of the basis lactose-containing raw materials for import substitution in medicine, veterinary, infant food and healthy nutrition has been developed.
PREDICTIVE AND PROGNOSTIC SIGNIFICANCE OF EXPRESSION AND ABERRATIONS OF THE DNA COPY NUMBER OF CHEMOSENSITIVITY GENES IN PATIENTS WITH BREAST CANCER
Authors: Zdereva E.A. , Tsyganov M. , Litvyakov N.V. , Ibragimova M.K.
Published: February 2023

Increasingly, researchers are focusing on the susceptibility of breast tumors (BC) to certain chemotherapy drugs and personalizing studies based on an assessment of this susceptibility. One such personalized approach is the assessment of chemotherapy gene expression and aberrations in the number of DNA copies — deletions and amplifications that affect gene activity. Comprehensive assessment of gene expression of chemotherapy drugs is important not only for understanding the heterogeneity and molecular biology of breast cancer, but also for obtaining a more accurate prognosis of the disease. Thus, the aim of the work is to analyze the relationship between the expression of chemosensitivity genes ERCC1, RRM1, TOP1, TOP2α, TUBB3, TYMS, GSTP1 and the effect of neoadjuvant chemotherapy (NCT).
DAIRY PRODUCT BIOTECHNOLOGY DEVELOPMENT FOR SPECIALIZED NUTRITION
Authors: Agibaeva A.Zh. , Gavrilova N.B. , Chernopol'skaya N.L.
Published: February 2023

The purpose of this study is to develop biotechnological parameters for the production of a
dairy product based on goat's milk and to determine its chemical composition and quality indicators,
which will make it possible to recommend it for use both for specialized and mass nutrition of the
population of various age groups. The article presents the results of research on the development of
a dairy product based on goat's milk for specialized nutrition.
MODERN ASSESSMENT OF ARTHROSPIRA AS A SOURCE OF FOOD AND BIOLOGICALLY ACTIVE SUBSTANCES
Authors: Kokoreva L. A. , Bagmut Yu. N. , Morozov D. E.
Published: February 2023

One of the main objectives of the state policy in the field of nutrition is to increase the production of functional products. Dried spirulina can become one of such functional products. Studies have established that it is rich in high-grade proteins, fats, carbohydrates, dietary fibers, vitamins and mineral elements, and an analysis of foreign and domestic literature proves its functional purpose. The article presents the results of determining the optimal application of spirulina in public catering dishes (products) that does not change their organoleptic characteristics.
USE OF PLANT RAW MATERIALS FOR THE DEVELOPMENT OF BIOTECHNOLOGY OF A FOOD ADDITIVE CONTAINING NATURAL SUPPLEMENTS
Authors: Konovalov S. A. , Gavrilova Natalya
Published: February 2023

A biotechnology has been developed for the production of food additives from plant materials containing natural biologically active substances, designed to enrich food products with a functional orientation.
VACUUM-FREE DRYING OF MILK-PROTEIN CONCENTRATES
Authors: Kurbanova Marina , Kryuk Roman , Muhsim-zade M. , Kalugina O. I. , Kolesnikov D. I.
Published: February 2023

The purpose of our work was to study the yield and physicochemical parameters of milk-protein concentrates obtained under the conditions of vacuum-free lyophilic drying.
BIOLOGICAL EFFECTS AND FRACTIONAL COMPOSITION OF COAL-ROCK PARTICLE MATTER
Authors: Larionov A. , Leshukov T. V. , Yakovenko O. S.
Published: February 2023

Aim: to evaluate separately the fractional composition of dust particles (PM – particle matter)
micro- (from 10 μm to 100 nm, PM10) and nanofractions (less than 100 nm, PM0.1), as well as their
biological effect by the DNA comet method on a culture of lung fibroblasts MRC-5. The most
abundant were 1.1-1.3 µm and 50-80 nm particles in micro- and nanofractions, respectively. A high
level of DNA disease is found in samples exposed to PM0.1 in searches with PM10.
ETHICAL PROBLEMS OF THE DEVELOPMENT OF GENETIC TECHNOLOGIES
Authors: Letov O. V.
Published: February 2023

Theses are devoted to ethical problems of development of genetic technologies. It is noted that
according to the estimates of the World Health Organization, in 2050 Alzheimer's disease (AD) will
suffer three times more people than today, as a result of which there is a need for the development of
early diagnosis. Screening methods are considered suitable for this purpose. To cope with the huge
financial and time costs of screening the entire population. This raises the following two ethical aspects.
First, for the sake of transparency, it is necessary to ensure that system AI is deployed for predictive
purposes. Secondly, the principle of respect for the freedom of the patient requires explanation.
FUNCTIONAL FOODS BASED ON WHEY PERMEATE
Authors: Lisicyn V. A. , Ivanec V. A. , Gavrish A. V. , Kalinina A. S.
Published: February 2023

Objective: to develop a technology for enriching bakery products with whey permate, improving
the baromembrane processing of secondary dairy raw materials
THE USE OF COLLAGEN STRUCTURES IN FUNCTIOAL PRODUCTS
Authors: Lobacheva Elena , Mozgovaya E. A.
Published: February 2023

Purpose: The current state and prospects of the production of functional nutrition products are
analyzed. Analysis of the conducted studies to develop a convenient and effective effect of collagen
structures on the prevention of osteoporosis with the use of herbal components.
THE EFFECT OF BIOLOGICALLY ACTIVE COMPOUNDS OF REAL GINSENG (PANAX GINSENG) ON THE GROWTH OF YEAST CELLS
Authors: Milentyeva Irina , Fedorova Anastasiya
Published: February 2023

The aim of this study is to study the direct effect of bioactive compounds of the extract of the
root culture of ginseng (Panax ginseng) on the growth of yeast cells Saccharomyces cerevisiae.
A MODEL OF GROWING PORCINI MUSHROOMS IN ARTIFICIAL CONDITIONS
Authors: Novoselov Sergey , Veremeenko I. P. , Isaeva N. V.
Published: February 2023

The relevance of the development of technology for growing porcini mushrooms in artificial
conditions on the basis of a substrate is considered. The therapeutic and preventive and nutritional
properties of the white mushroom, as well as its practical application, are described. A technical and
technological solution of the technology of growing porcini mushrooms in artificial conditions
based on the method of scientific and technical creativity has been developed. The prospects of
enriching porcini mushrooms with compounds and elements useful for the body are described
ETHNIC DIFFERENCES IN THE LENGTH OF CAG REPEATS IN THE ANDROGEN RECEPTOR GENE AND TESTOSTERONE LEVELS IN YOUNG MEN OF THE SIBERIAN REGION OF RUSSIA
Authors: Onopchenko M. A. , Vasil'ev G. V. , Osadchuk A. V. , Osadchuk L. V.
Published: February 2023

The aim of the study was to identify ethnic differences in the number of CAG repeats of the
androgen receptor gene (AR), anthropometric and hormonal indicators in men of three ethnic groups
(Slavs, Buryats and Yakuts) living in the Russa. The androgen receptor mediates the effects of
androgens on a wide range of organs and tissues in men. The AR is characterized by polymorphism
of CAG repeats, which can be an ethno-dependent trait and determine functional and
morphogenetic effects of testosterone. The study established the ethnic differences in the length of
CAG repeats between the Slavs, Buryats and Yakuts (23, 24, 25 triplets, respectively), as well as in
anthropometric and hormonal indicators. LH concentrations were higher in Buryats than in Slavs or
Yakuts, but the testosterone level was the lowest in Buryats compared to Slavs or Yakuts.
MODERN ASPECTS OF SPECIALIZED NUTRITION FOR ATHLETES
Authors: Plotnikov D. A. , Burakova L. N. , Popov V. G.
Published: February 2023

The purpose of this work is to analyze the current state of specialized nutrition for athletes.