bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementation of XMPP Protocol on Android Pulse Filling Application
Authors: Hermawan Aditiya , Setiawan Agus
Published: April 2018

Along with the increasing capabilities of mobile devices, the need for pulses is also growing rapidly. Currently resellers only utilize the technology SMS (Short Message Service) in conventional to conduct transactions. To assist in the more efficient pulse delivery process, it was built using the XMPP protocol. In this study using Extreme Programming design method with 4 (four) stages of process planning, design process, coding process and testing process. The results of testing conducted by using black box testing as well as questionnaires from the resellers, applications that help in the transaction pulse, and improve the efficiency of time in the process of pulse delivery.
Perancangan Aplikasi Penentu Jurusan IPA atau IPS Pada SMA Menggunakan Fuzzy Logic
Authors: Kurnia Yusuf , Sagara Dharma
Published: April 2018

Penelitian ini didasari oleh kurangnya persiapan siswa dalam memilih penjurusan yang tepat akan berdampak pada pelajaran yang nantinya akan di pelajarinya. Perkembangan teknologi yang semakin canggih yang sekarang telah membuat banyak organisasi atau lembaga menggunakannya sebagai media yang pengolahan data, mendukung kemampuan Komputer dalam pengolahan data telah sangat mendukung dalam menghadirkan information bahwa mudah, akurat dan berkualitas. Seperti dengan organisasi atau lembaga lain. Pada penelitian akan menerapkan logika fuzzy metode Tsukamoto dalam mencari penjurusan yang tepat pada siswa di SMA. Keuntungan penggunaan logika fuzzy adalah dapat melakukan observasi objektif terhadap nilai-nilai yang bersifat subjektif. Adapun variable yang akan diproses dalam logika fuzzy adalah  nilai dan minat. Hasil tes siswa akan menjadi nilai masukkan yang kemudian  diproses didalam logika fuzzy. Nilai tersebut diproses kedalam tiga tahapan logika fuzzy yaitu fuzzifikasi, penalaran dan defuzzifikasi. Hasil dari penjurusan ini yang kemudian akan menjadi panduan siswa dalam mengoptimasi proses pembelajaran.
Application of Neural Network Methods Based on Genetic Algorithm for Breast Cancer Prediction
Authors: Rino Rino
Published: April 2018

Cancer is a major challenge for mankind. Cancer can affect various parts of the body. This deadly disease can be detected in people of all ages. However, the risk of cancer increases with increasing age. Breast cancer is the most common cancer among women, and form largest cause of death for women as well. Then there are problems in the detection of breast cancer, resulting in the patient experiencing unnecessary treatment and cost. Insimilar studies, there are several methods used but there are problems due to the shape of the cancer cells are nonlinear. Neural networks can solve these problems, but neural network is weak in terms of determining the value of the parameter, so it needs to be optimized. Genetic algorithm is one of the optimization methods is good, therefore the values ​​of the parameters of the neural network will be optimized by using a genetic algorithm so as to get the best value of the parameter. Neural Network-based GA algorithm has the higher accuracy value than just using Neural Network algorithm. This is evident from the increase in value for the accuracy of the model Neural Network algorithm by 95.42% and the accuracy of algorithm-based Neural Network algorithm GA (Genetic Algorithm) of 96.85% with a difference of 1.43% accuracy. So it can be concluded that the application of Genetic Algorithm optimization techniques to improve the accuracy values on Neural Network algorithm.
Analisis Performance Fuzzy Tsukamoto Dalam Klasifikasi Bantuan Kemiskinan
Authors: Redjeki Sri
Published: April 2018

The Central Bureau of Statistics (BPS) showed that the poverty rate in Indonesia in September 2014 still high at about 27.7 million people, or about 10.96%. As a basis for policy countermeasures, understand the problem of poverty often demands the effort of defining, measuring, and identifying the root causes of poverty. This study wanted to use one of the methods that exist in fuzzy logic to classify beneficiaries of poverty that exist in Bantul. Fuzzy Inference System used in this study using Tsukamoto with 8 rule established by a group of poor criteria and types of poverty relief. There are three groups of criteria of poverty derived from 11 criteria of poverty in Bantul. While the types of assistance that are used are Raskin, BLT and KUR. The system is built using PHP. To see the performance Tsukamoto method in this study used 50 data poor people in Sub Districs Banguntapan. From the test results turned out to obtained an accuracy of 52%, meaning that there were 26 correct data according to the original data. It is necessary to modify the rules and membership functions to improve system accuracy results
Monitoring Computer Activities with Cloud to Device Messaging (C2DM)
Authors: Witno Suwitno , Rino Rino
Published: April 2018

In a particular division, a supervisor needs to perform monitoring of the activities carried out at his employers to improve the performance of the work of his subordinates. Leaders are often not in place to monitor the activities of his subordinates in carrying out their responsibilities. One solution to overcome these problems is to supervise the use of their computer by means of push notification. By utilizing the technology of Cloud to Device Messaging (C2DM), supervisor can monitor computer activities of his employers anywhere. Given this research, is expected to help the supervisor in monitoring his employers despite not being in place. This may indirectly improve performance in a division. For further research can be developed monitoring in a real time.
Data Mining Implementation on Choosing Potential Customers Using K-Means Algorithm on PT. Koba Metal Indonesia
Authors: Kristianto Sandi , Kurnia Yusuf
Published: April 2018

PT. Koba metal Indonesia. is one of roll-reforming cooperations who produce light-steel stuffs which is growing rapidly nowadays. One of the important thing in customer management is how a cooperation be able to preserve their customers. the effort of preserving customers becomes important for PT. Koba metal Indonesia. considering of plenty companies who commits at the same sector. To prevent the displacement of customers, knowing the potential group of customers is important, so that the company could preserve those potential customers by giving excellent service, etc. the implication of data mining could assist the company to analize the received data from sales transaction to gain potential customers data. Therefore, a designed application which could implement the data mining for choosing potential customers by clustering and algorithm K-means method is arranged. Then, the information performes with groups who is categorized into potential customers. Besides, rapminder application is also used to  examine the data’s accuracy  of this built application design. Hereinafter, this application design is expected to assist companies to choose their potential customers and preserve them to advance their business.
Les Fransaskois et les diplômés d'immersion française: comparaison de leurs erreurs à l'écrit
Authors: Cox Terry B.
Published: April 2018

Dans cet article, nous décrivons une étude répétée au cours de trois années universitaires consécutives qui visait le contrôle et la correction de l'écrit des étudiants bilingues fransaskois et des diplômés des cours d'immersion qui, pour des raisons économiques, étaient dans la même classe. Sur les devoirs des étudiants, préparés sur disquette, nous identifions toutes les erreurs lexico-grammaticales qu'ils avaient à corriger. Les objectifs principaux étaient: (1) de déterminer si les francophones et les anglophones commettaient des erreurs similaires ou différentes; et (2) de décider si on peut combiner ces deux groupes sans désavantage majeur ni pour l'un ni pour l'autre. L'auteur présente les résultats de l'analyse des erreurs qui portent à croire que les deux groupes commettaient des erreurs similaires et que la tactique de combiner ces deux groupes dans la même classe ne s'avère pas déconseillée.
Changing Tetra Pak: From Waste to Resource
Authors: Ma Yuhui
Published: April 2018

In recent years, the problem caused by Tetra Pak waste (TPW) has became a topic of great concern to scientists and environmentalists, and commercial companies have also begun to take an interest in developing processes for tackling this issue. In this article, the challenges in the recycling of TPW are described. This article presents the major conclusions of previously published works focussed on the utilisation of TPW for energy and material purposes. The commercial utilisation of TPW is also described. Some suggestions for better recycling of TPW are given in the latter part of this work.
Electrical stimulation on open wound healing in Rabbits
Authors: Mia MH , Hossain MM , Rima UK , Rahman MM , Alam MR , Haq MM , Samaddar K , Kundu P , Khan Mahna
Published: April 2018

Micro-amperage electrical stimulation (MES) on the healing process of skin wound in rabbits was studied. Twenty adult New Zealand white rabbits were randomly divided into four equal groups and a full thickness skin incision was made in each rabbit. This experimental group received an MES of 1000 μA (1mA) current intensity for 30 minutes twice a day. Swelling area of the wound of experimental groups were 11.1cd ± 0.2 mm, 10.8d ± 0.1 mm and 10.7cd ± 0.1mm at days 4, 7 and15, respectively. Elevation of sutured line (mm) of experimental groups was 2.4b ± 0.1, 2.1b ± 0.1, 2.2b ± 0.1 at days 4, 7 and 15, respectively. The average healing time was 30.4b, 28.4b and 26.4b in days 4, 7 and 15, respectively, significantly different from control groups. Number of fibroblasts and blood vessels were significantly higher in the experimental group than in control group. The result indicates that the application of MES significantly enhances the wound healing in rabbits.Bangl. vet. 2016. Vol. 33, No. 2, 51-61
Sensing Technologies for Precision Phenotyping in Vegetable Crops: Current Status and Future Challenges
Authors: Tripodi Pasquale , Massa Daniele , Venezia Accursio , Cardi Teodoro
Published: April 2018

Increasing the ability to investigate plant functions and structure through non-invasive methods with high accuracy has become a major target in plant breeding and precision agriculture. Emerging approaches in plant phenotyping play a key role in unraveling quantitative traits responsible for growth, production, quality, and resistance to various stresses. Beyond fully automatic phenotyping systems, several promising technologies can help accurately characterize a wide range of plant traits at affordable costs and with high-throughput. In this review, we revisit the principles of proximal and remote sensing, describing the application of non-invasive devices for precision phenotyping applied to the protected horticulture. Potentiality and constraints of big data management and integration with “omics” disciplines will also be discussed.
Laser Scribed Graphene Biosensor for Detection of Biogenic Amines in Food Samples Using Locally Sourced Materials
Authors: Vanegas Diana C. , Patiño Laksmi , Mendez Connie , Oliveira Daniela Alves de , Torres Alba M. , Gomes Carmen L. , McLamore Eric S.
Published: April 2018

In foods, high levels of biogenic amines (BA) are the result of microbial metabolism that could be affected by temperatures and storage conditions. Thus, the level of BA is commonly used as an indicator of food safety and quality. This manuscript outlines the development of laser scribed graphene electrodes, with locally sourced materials, for reagent-free food safety biosensing. To fabricate the biosensors, the graphene surface was functionalized with copper microparticles and diamine oxidase, purchased from a local supermarket; and then compared to biosensors fabricated with analytical grade materials. The amperometric biosensor exhibits good electrochemical performance, with an average histamine sensitivity of 23.3 µA/mM, a lower detection limit of 11.6 µM, and a response time of 7.3 s, showing similar performance to biosensors constructed from analytical grade materials. We demonstrated the application of the biosensor by testing total BA concentration in fish paste samples subjected to fermentation with lactic acid bacteria. Biogenic amines concentrations prior to lactic acid fermentation were below the detection limit of the biosensor, while concentration after fermentation was 19.24 ± 8.21 mg histamine/kg, confirming that the sensor was selective in a complex food matrix. The low-cost, rapid, and accurate device is a promising tool for biogenic amine estimation in food samples, particularly in situations where standard laboratory techniques are unavailable, or are cost prohibitive. This biosensor can be used for screening food samples, potentially limiting food waste, while reducing chances of foodborne outbreaks.
Abuse of Prescription Drugs in the Context of Novel Psychoactive Substances (NPS): A Systematic Review
Authors: Schifano Fabrizio , Chiappini Stefania , Corkery John , Guirguis Amira
Published: April 2018

Recently, a range of prescription and over-the-counter drugs have been reportedly used as Novel Psychoactive Substances (NPS), due to their potential for abuse resulting from their high dosage/idiosyncratic methods of self-administration. This paper provides a systematic review of the topic, focusing on a range of medications which have emerged as being used recreationally, either on their own or in combination with NPS. Among gabapentinoids, pregabalin may present with higher addictive liability levels than gabapentin, with pregabalin being mostly identified in the context of opioid, polydrug intake. For antidepressants, their dopaminergic, stimulant-like, bupropion activities may explain their recreational value and diversion from the therapeutic intended use. In some vulnerable clients, a high dosage of venlafaxine (‘baby ecstasy’) is ingested for recreational purposes, whilst the occurrence of a clinically-relevant withdrawal syndrome may be a significant issue for all venlafaxine-treated patients. Considering second generation antipsychotics, olanzapine appears to be ingested at very large dosages as an ‘ideal trip terminator’, whilst the immediate-release quetiapine formulation may possess proper abuse liability levels. Within the image- and performance- enhancing drugs (IPEDs) group, the beta-2 agonist clenbuterol (‘size zero pill’) is reported to be self-administered for aggressive slimming purposes. Finally, high/very high dosage ingestion of the antidiarrhoeal loperamide has shown recent increasing levels of popularity due to its central recreational, anti-withdrawal, opiatergic effects. The emerging abuse of prescription drugs within the context of a rapidly modifying drug scenario represents a challenge for psychiatry, public health and drug-control policies.
Selective Hydrogenation of Benzene to Cyclohexene over Monometallic Ru Catalysts: Investigation of ZnO and ZnSO4 as Reaction Additives as Well as Particle Size Effect
Authors: Sun Haijie , Chen Zhihao , Li Chenggang , Chen Lingxia , Li Yan , Peng Zhikun , Liu Zhongyi , Liu Shouchang
Published: April 2018

Monometallic Ru catalysts with different particle size were prepared via a precipitation method and reduced at different temperatures. In addition, their catalytic activity towards cyclohexene formation from selective hydrogenation of benzene was investigated. With the utilization of ZnO and ZnSO4 as reaction additives, (Zn(OH)2)3(ZnSO4)(H2O)3 could be generated and chemisorbed on the Ru surface, which played a crucial role on increasing the selectivity to cyclohexene and retarding the catalytic activity towards benzene conversion. Interestingly, without addition of ZnO and ZnSO4, no cyclohexene was observed over all tested Ru catalysts with different particle sizes. This suggested that particle size plays no role in cyclohexene synthesis from selective hydrogenation of benzene over the pure monometallic Ru catalysts in the absence of ZnO and ZnSO4. On the other hand, when both ZnO and ZnSO4 were applied, surface n(Zn2+)/n(Ru) molar ratio increased with increasing particle size of the monometallic Ru catalysts after catalytic experiments, demonstrating that the content of chemisorbed (Zn(OH)2)3(ZnSO4)(H2O)3 on Ru catalysts surface is enhanced under such a circumstance. More importantly, the maximum cyclohexene yield obtained over monometallic Ru catalysts showed a volcanic-type variation with increasing particle size of Ru from 3.6 nm to 5.6 nm. When the particle size of the monometallic Ru catalyst was 4.7 nm, the highest cyclohexene yield of 60.4% was achieved with an optimum n(ZnO)/n(Ru) ratio of 0.19:1 in the presence of 0.62 mol·dm−3 ZnSO4 within 25 min of catalytic experiments at 423 K under 5.0 MPa of H2. In addition, no decrease of catalytic activity towards cyclohexene generation was observed over this catalyst after 10 catalytic experiments without any regeneration.
RetroTransformDB: A Dataset of Generic Transforms for Retrosynthetic Analysis
Authors: Avramova Svetlana , Kochev Nikolay , Angelov Plamen
Published: April 2018

Presently, software tools for retrosynthetic analysis are widely used by organic, medicinal, and computational chemists. Rule-based systems extensively use collections of retro-reactions (transforms). While there are many public datasets with reactions in synthetic direction (usually non-generic reactions), there are no publicly-available databases with generic reactions in computer-readable format which can be used for the purposes of retrosynthetic analysis. Here we present RetroTransformDB—a dataset of transforms, compiled and coded in SMIRKS line notation by us. The collection is comprised of more than 100 records, with each one including the reaction name, SMIRKS linear notation, the functional group to be obtained, and the transform type classification. All SMIRKS transforms were tested syntactically, semantically, and from a chemical point of view in different software platforms. The overall dataset design and the retrosynthetic fitness were analyzed and curated by organic chemistry experts. The RetroTransformDB dataset may be used by open-source and commercial software packages, as well as chemoinformatics tools.
Assessment of Chimpanzee Nest Detectability in Drone-Acquired Images
Authors: Bonnin Noémie , Van Andel Alexander C. , Kerby Jeffrey T. , Piel Alex K. , Pintea Lilian , Wich Serge A.
Published: April 2018

As with other species of great apes, chimpanzee numbers have declined over the past decades. Proper conservation of the remaining chimpanzees requires accurate and frequent data on their distribution and density. In Tanzania, 75% of the chimpanzees live at low densities on land outside national parks and little is known about their distribution, density, behavior or ecology. Given the sheer scale of chimpanzee distribution across western Tanzania (>20,000 km2), we need new methods that are time and cost efficient while providing precise and accurate data across broad spatial scales. Scientists have recently demonstrated the usefulness of drones for detecting wildlife, including apes. Whilst direct observation of chimpanzees is unlikely given their elusiveness, we investigated the potential of drones to detect chimpanzee nests in the Issa valley, western Tanzania. Between 2015 and 2016, we tested and compared the capabilities of two fixed-wing drones. We surveyed twenty-two plots (50 × 500 m) in gallery forests and miombo woodlands to compare nest observations from the ground with those from the air. We performed mixed-effects logistic regression models to evaluate the impact of image resolution, seasonality, vegetation type, nest height and color on nest detectability. An average of 10% of the nests spotted from the ground were detected from the air. From the factors tested, only image resolution significantly influenced nest detectability in drone-acquired images. We discuss the potential, but also the limitations, of this technology for determining chimpanzee distribution and density and to provide guidance for future investigations on the use of drones for ape population surveys. Combining traditional and novel technological methods of surveying allows more accurate collection of data on animal distribution and habitat connectivity that has important implications for ape conservation in an increasingly anthropogenically-disturbed landscape.
Web-Based Parenting Support: Development of the COPING Confident Parenting Programme
Authors: Hutchings Judith , Owen Dawn , Williams Margiad
Published: April 2018

Parents have the most significant impact on children’s development and the key parenting factors that promote child development and wellbeing are well known. Furthermore, many behavioural, social and emotional problems in children are associated with poor parenting practices. Parenting interventions that address parental skill deficits and teach positive parenting principles based on social learning theory are effective and are the recommended treatment for conduct disorder. Alongside the development of treatment programmes, universal parenting programmes have been developed; many present the same core parenting principles but their rationales vary from promoting children’s development to addressing common behavioural challenges and the evidence for these programmes is less well established. Most parents now have internet access and are making daily use of it, including seeking advice on parenting matters but that advice is often anecdotal and lacking evidence. In the meantime, a small number of web-based programmes, including parenting programmes have been developed and evaluated. This paper summarises the rationale for web-based universal programmes to support parents and briefly describes the history, content and a summary of the initial research on the COPING (confident parent internet guide) programme developed by the authors. The paper concludes with suggestions for future research directions.
Quality of Life After Sentinel Lymph Node Biopsy Versus Complete Axillary Lymph Node Dissection in Early Breast Cancer: A 3-Year Follow-up Study
Authors: Boguševičius Algirdas , Čepulienė Daiva
Published: April 2018

Background and Objectives. The rating of life quality may belong to the method of surgical treatment: after the axillary lymph node dissection patients may suffer from arm symptoms; after sentinel lymph node biopsy women may highlight the anxiety about the success of radical treatment. The aim was to assess the influence of sentinel lymph node biopsy on the quality of life of the patients with early stage breast cancer compared with total axillary lymph node dissection. Material and Methods. In a prospective case-control study, 48 patients with early invasive breast cancer and no evidence of lymph nodes involvement underwent breast conserving surgery with sentinel lymph node biopsy. They were grouped as matched pairs with the patients who underwert axillary lymph node dissection, according to the age, TNM stage, localization, hormonal receptor status, and surgical characteristics. Quality of life was evaluated using the QLQ-C30 and QLQ-BR-23 questionnaires before surgery and after 1, 3, 6, 12, and 36 months. Results. The patients who underwent sentinel lymph node biopsy scored better on the emotional functioning, pain, sexual functioning, and future perspective scales in comparison with those who underwent axillary lymph node dissection. The score on the arm symptom scale remained significantly better in the sentinel lymph node biopsy group than the axillary lymph node dissection group within the overall follow-up period. Conclusions. The women who underwent sentinel lymph node biopsy experienced better quality of life than the patients who underwent axillary lymph node dissection.
Surface Nitridation of Aluminum Nanoparticles by Off-Line Operation and Its Kinetics Analysis
Authors: Yi Yong , Li Dai , Ma Daichuan , Luo Daibing , Yang Weizhong , Ma Wangjing
Published: April 2018

To improve combustion efficiency and anti-oxidation property of aluminum nanoparticles (ANs), surface nitridation of ANs was performed in a pipe furnace under the protection of nitrogen gas in a glove-operation hermetic box via an off-line nitridation process. The product was characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS) analysis. A core-shell nanostructure with an aluminum nitride (AlN) coating on the ANs core was observed. The empirical kinetic triplets (Ea, A, and f(α)) for the nitridation of ANs, for the first time, were calculated and analyzed using five types of iso-conversional methods and a differentiation method. The effects of the kinetics of the reaction were investigated by simultaneous differential scanning calorimetry–thermogravimetry (DSC-TG) and thermal analysis using linear programmed temperature at different heating rates.
Co-Localization of Crotamine with Internal Membranes and Accentuated Accumulation in Tumor Cells
Authors: Mambelli-Lisboa Nicole , Sciani Juliana Mozer , Brandão Prieto da Silva Alvaro Rossan , Kerkis Irina
Published: April 2018

Crotamine is a highly cationic; cysteine rich, cross-linked, low molecular mass cell penetrating peptide (CPP) from the venom of the South American rattlesnake. Potential application of crotamine in biomedicine may require its large-scale purification. To overcome difficulties related with the purification of natural crotamine (nCrot) we aimed in the present study to synthesize and characterize a crotamine analog (sCrot) as well investigate its CPP activity. Mass spectrometry analysis demonstrates that sCrot and nCrot have equal molecular mass and biological function—the capacity to induce spastic paralysis in the hind limbs in mice. sCrot CPP activity was evaluated in a wide range of tumor and non-tumor cell tests performed at different time points. We demonstrate that sCrot-Cy3 showed distinct co-localization patterns with intracellular membranes inside the tumor and non-tumor cells. Time-lapse microscopy and quantification of sCrot-Cy3 fluorescence signalss in living tumor versus non-tumor cells revealed a significant statistical difference in the fluorescence intensity observed in tumor cells. These data suggest a possible use of sCrot as a molecular probe for tumor cells, as well as, for the selective delivery of anticancer molecules into these tumors.
Application of the Response Surface Methodology to Optimize the Fermentation Parameters for Enhanced Docosahexaenoic Acid (DHA) Production by Thraustochytrium sp. ATCC 26185
Authors: Wu Kang , Ding Lijian , Zhu Peng , Li Shuang , He Shan
Published: April 2018

The aim of this study was to determine the cumulative effect of fermentation parameters and enhance the production of docosahexaenoic acid (DHA) by Thraustochytrium sp. ATCC 26185 using response surface methodology (RSM). Among the eight variables screened for effects of fermentation parameters on DHA production by Plackett-Burman design (PBD), the initial pH, inoculum volume, and fermentation volume were found to be most significant. The Box-Behnken design was applied to derive a statistical model for optimizing these three fermentation parameters for DHA production. The optimal parameters for maximum DHA production were initial pH: 6.89, inoculum volume: 4.16%, and fermentation volume: 140.47 mL, respectively. The maximum yield of DHA production was 1.68 g/L, which was in agreement with predicted values. An increase in DHA production was achieved by optimizing the initial pH, fermentation, and inoculum volume parameters. This optimization strategy led to a significant increase in the amount of DHA produced, from 1.16 g/L to 1.68 g/L. Thraustochytrium sp. ATCC 26185 is a promising resource for microbial DHA production due to the high-level yield of DHA that it produces, and the capacity for large-scale fermentation of this organism.
Biomedical Applications of Polylactide (PLA) and Its Copolymers
Authors: Giammona Gaetano , Craparo Emanuela Fabiola
Published: April 2018

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Development of Triamcinolone Acetonide-Loaded Nanostructured Lipid Carriers (NLCs) for Buccal Drug Delivery Using the Box-Behnken Design
Authors: Kraisit Pakorn , Sarisuta Narong
Published: April 2018

The aim of this present work was to prepare triamcinolone acetonide (TA)-loaded nanostructured lipid carriers (TA-loaded NLCs) for buccal drug delivery systems using the Box-Behnken design. A hot homogenization method was used to prepare the TA-loaded NLCs. Spermaceti (X1), soybean oil (X2), and Tween 80 (X3) were used as solid lipid, liquid lipid, and stabilizer, respectively. The particle size of TA-loaded NLCs was lower than 200 nm and the zeta potential displayed the negative charge in all formulations. The percentage encapsulation efficiency (%EE) of the TA-loaded NLCs showed that it was higher than 80% for all formulations. Field emission scanning electron microscope (FESEM) confirmed that the size of TA-loaded NLCs was approximately 100 nm and energy-dispersive X-ray spectroscopy (EDS) confirmed that the TA could be incorporated in the NLC system. The Higuchi model gave the highest value of the R2, indicating that this model was a fit for the TA release profiles of TA-loaded NLCs. Confocal laser scanning microscopy (CLSM) was used to observe the drug penetration within the porcine buccal mucosa and Nile red-loaded NLCs showed significantly higher penetration depth at 8 h than at 2 h. Therefore, TA-loaded NLCs could be an efficient carrier for drug delivery through the buccal mucosa.
Non-Canonical Activation of the Epidermal Growth Factor Receptor by Carbon Nanoparticles
Authors: Stöckmann Daniel , Spannbrucker Tim , Ale-Agha Niloofar , Jakobs Philipp , Goy Christine , Dyballa-Rukes Nadine , Hornstein Tamara , Kümper Alexander , Kraegeloh Annette , Haendeler Judith , Unfried Klaus
Published: April 2018

The epidermal growth factor receptor (EGFR) is an abundant membrane protein, which is essential for regulating many cellular processes including cell proliferation. In our earlier studies, we observed an activation of the EGFR and subsequent signaling events after the exposure of epithelial cells to carbon nanoparticles. In the current study, we describe molecular mechanisms that allow for discriminating carbon nanoparticle-specific from ligand-dependent receptor activation. Caveolin-1 is a key player that co-localizes with the EGFR upon receptor activation by carbon nanoparticles. This specific process mediated by nanoparticle-induced reactive oxygen species and the accumulation of ceramides in the plasma membrane is not triggered when cells are exposed to non-nano carbon particles or the physiological ligand EGF. The role of caveolae formation was demonstrated by the induction of higher order structures of caveolin-1 and by the inhibition of caveolae formation. Using an in vivo model with genetically modified mice lacking caveolin-1, it was possible to demonstrate that carbon nanoparticles in vivo trigger EGFR downstream signaling cascades via caveolin-1. The identified molecular mechanisms are, therefore, of toxicological relevance for inhaled nanoparticles. However, nanoparticles that are intentionally applied to humans might cause side effects depending on this phenomenon.
ZnO Nanostructures for Drug Delivery and Theranostic Applications
Authors: Martínez-Carmona Marina , Gun’ko Yurii , Vallet-Regí María
Published: April 2018

In the last two decades, zinc oxide (ZnO) semiconductor Quantum dots (QDs) have been shown to have fantastic luminescent properties, which together with their low-cost, low-toxicity and biocompatibility have turned these nanomaterials into one of the main candidates for bio-imaging. The discovery of other desirable traits such as their ability to produce destructive reactive oxygen species (ROS), high catalytic efficiency, strong adsorption capability and high isoelectric point, also make them promising nanomaterials for therapeutic and diagnostic functions. Herein, we review the recent progress on the use of ZnO based nanoplatforms in drug delivery and theranostic in several diseases such as bacterial infection and cancer.
A Corpus-Based Study on Cross-Cultural Divergence in the Use of Hedges in Academic Research Articles Written by Vietnamese and Native English-Speaking Authors
Authors: Nguyen Thi Thuy Thu
Published: April 2018

As an interpersonal meta-discourse device, hedges have a significant role in academic writing, especially in research articles (RAs) of various fields. The use of hedges in academic writing helps writers represent their ideology, opinion, and evaluation of issues, as well as to persuade readers to accept their claims. This study examined the cultural divergence in the use of hedges in the results and discussion sections of RAs written by Vietnamese and native English-speaking authors, analyzing the variation in the frequency and types of hedges within the rhetorical structure of RAs. The study was based on the data of two corpora, which were collected from 100 RAs that were judged by the authors’ names and affiliations in the field of applied linguistics, consisting of 50 RAs that were written by Vietnamese writers (VNRAs) and published in Vietnamese national journals, and 50 RAs that were written by native English-speaking authors (NESRAs) and published in international journals. Contrastive analysis of the frequency and types of hedges used in RAs written by Vietnamese and native English-speaking authors revealed that there were variations and similarities in the way they utilized hedges as interpersonal meta-discourse devices to guide, negotiate, and persuade readers to accept their assertions and viewpoint, and in the way the negative politeness strategy was used to respect the readership and give more room for the readers’ alternative interpretations. The difference between the VNRA and NESRA corpora was in the frequency of the occurrence of hedges, which was relatively lower in the RAs written by Vietnamese authors. The reason for this divergence could be due to the culturally diverse backgrounds, the intended readers, and the conventional rules of two discourse communities.
Impact of Future Climate Change on Wheat Production: A Simulated Case for China’s Wheat System
Authors: Xiao Dengpan , Bai Huizi , Liu De Li
Published: April 2018

With regard to global climate change due to increasing concentration in greenhouse gases, particularly carbon dioxide (CO2), it is important to examine its potential impact on crop development and production. We used statistically-downscaled climate data from 28 Global Climate Models (GCMs) and the Agricultural Production Systems sIMulator (APSIM)–Wheat model to simulate the impact of future climate change on wheat production. Two future scenarios (RCP4.5 and RCP8.5) were used for atmospheric greenhouse gas concentrations during two different future periods (2031–2060 referred to as 40S and 2071–2100 referred to as 80S). Relative to the baseline period (1981–2010), the trends in mean daily temperature and radiation significantly increased across all stations under the future scenarios. Furthermore, the trends in precipitation increased under future climate scenarios. Due to climate change, the trend in wheat phenology significantly advanced. The early flowering and maturity dates shortened both the vegetative growth stage (VGP) and the whole growth period (WGP). As the advance in the days of maturity was more than that in flowering, the length of the reproductive growth stage (RGP) of spring wheat was shortened. However, as the advance in the date of maturity was less than that of flowering, the RGP of winter wheat was extended. When the increase in CO2 concentration under future climate scenarios was not considered, the trend in change in wheat production for the baseline declined. In contrast, under increased CO2 concentration, the trend in wheat yield increased for most of the stations (except for Nangong station) under future climatic conditions. Winter wheat and spring wheat evapotranspiration (ET) decreased across all stations under the two future climate scenarios. As wheat yield increased with decreasing water consumption (as ET) under the future climatic conditions, water use efficiency (WUE) significantly improved in the future period.
The Influence of Host Volunteer Motivation on Satisfaction and Attitudes Toward Sochi 2014 Olympic Games
Authors: Vetitnev Alexandr , Bobina Nadezhda , Terwiel F. Anne
Published: April 2018

This article presents the results of a study of the host volunteer's motivation at the Sochi 2014 Winter Olympic Games, and the impact of motivation on volunteer satisfaction and volunteer attitude toward the Games. A modified VMS-ISE scale was used to identify five motivational groups.
Differences in motivation between groups of volunteers were distinguished by sociodemographic and behavioral factors. Motivational factors were related to host volunteer satisfaction and their support for these Games. Structural equation modeling (SEM) illuminated a significant positive relationship
between satisfaction and three of five motivational factors (expression of values, career orientation, extrinsic rewards), as well as between volunteer satisfaction and attitude toward the Games. The commitment and tradition had a negative impact on satisfaction. Local volunteers who had a
positive relationship with the event were more likely to display supporting behavior, such as the desire to learn a foreign language.
Mega-Sports Events and Stock Market Returns: The Case of the 2022 World Cup
Authors: Eissa Mohamed Abdelaziz , Al Refai Hisham
Published: April 2018

This study examines the impact of the FIFA's official announcements on Doha Stock Exchange (DSE) of Qatar with respect to the 2022 World Cup. Using the abnormal unsystematic return method of Savickas, our findings reveal that the relationship between this sports mega-event and the DSE
is significant, indicating that the market is very sensitive to FIFA's announcements about the 2022 World Cup. The highly significant reactions of the DSE reveal investors' positive (or negative) feelings that the government and private expenditure on medium- and long-term projects undertaken
in anticipation of hosting the Cup will affect future trading volumes in DSE. Any future announcements, good or bad, are likely to affect companies investing in these huge projects, impacting on their share value and triggering portfolio reallocation by local and international investors, leading
to increased abnormal return.
Wandering Supermassive Black Holes in Milky-Way-mass Halos
Authors: Tremmel Michael , Governato Fabio , Volonteri Marta , Pontzen Andrew , Quinn Thomas R.
Published: April 2018

We present a self-consistent prediction from a large-scale cosmological simulation for the population of “wandering” supermassive black holes (SMBHs) of mass greater than 106
M
⊙ on long-lived, kpc-scale orbits within Milky Way (MW)-mass galaxies. We extract a sample of MW-mass halos from the Romulus25 cosmological simulation, which is uniquely able to capture the orbital evolution of SMBHs during and following galaxy mergers. We predict that such halos, regardless of recent merger history or morphology, host an average of 5.1 ± 3.3 SMBHs, including their central black hole, within 10 kpc from the galactic center and an average of 12.2 ± 8.4 SMBHs total within their virial radius, not counting those in satellite halos. Wandering SMBHs exist within their host galaxies for several Gyr, often accreted by their host halo in the early Universe. We find, with >4σ significance, that wandering SMBHs are preferentially found outside of galactic disks.
Avant-propos
Authors: Krikorian Gaëlle
Published: April 2018

Résumé Il se passe depuis plusieurs années des choses que l’on peut qualifier d’anormales. En France, et en Europe.
Expulsion, pouvoir, mobilisation
Authors: De Genova Nicholas , Lecadet Clara , Walters William
Published: April 2018

Résumé Ce qu’expulser veut dire.
Une saison d’errance, sur les camps
Authors: Genz Laura
Published: April 2018

Résumé Portfolio
Autonomie des luttes, mode d’emploi
Authors: Gallienne Emmanuelle , Lecadet Clara
Published: April 2018

Résumé Entretien avec Anzoumane Sissoko
Le Resome : une mobilisation par les écoles
Authors: Resome Collectif
Published: April 2018

Résumé Fac ouverte
Donner les clés
Authors: Gallienne Emmanuelle
Published: April 2018

Résumé En Français dans le texte
Loving the Alien . La grâce de Bowie
Authors: Carnevali Barbara , Momboisse Yvon
Published: April 2018

Résumé Let’s dance
La prohibition, au cœur de la diffusion des drogues ?
Authors: Lalande Aude
Published: April 2018

Résumé Héroïne urbaine
Arrêt des soins d’un mineur : intérêt supérieur de l’enfant versus bienfaisance à l’égard des parents ?
Authors: Bourdaire-Mignot Camille , Gründler Tatiana
Published: April 2018

Dans une situation d’obstination déraisonnable, un médecin peut décider de l’arrêt des traitements sur un enfant mineur contre l’avis de ses parents. Mais, dans un tel contexte, il lui reviendra d’apprécier l’opportunité de la mise en œuvre de sa décision. Le Conseil d’État l’affirme ; la Cour européenne le confirme.
Improving Distance Student Retention Through Satisfaction and Authentic Experiences
Authors: Bornschlegl Madeleine , Cashman David
Published: April 2018

As attrition rates of Australian undergraduate distance programs are consistently high, this article investigates whether retention can be increased by increasing the students' satisfaction through improving the student experience. This project examines the distance student experience informed by students' satisfaction with already identified crucial program factors. The authors propose that the Experience Economy model, utilised in tourism studies and general economics, is also relevant to education. An online survey collected data from 75 undergraduate distance students. Gathered data was analysed using two simple mediation models. The distance student experience and the students' satisfaction with crucial program factors were strongly indirectly related to the students' intention to persist through the students' overall satisfaction. The results indicate that designers of tertiary distance courses should consider program factors and the characteristics of the distance student experience to ensure high levels of student satisfaction and to increase the students' intention to persist.
Contribution of New Technologies in the Relationship Between the Governance and the Social Responsibility at the Moroccan University
Authors: El Hissi Youmna , Benjouid Zakaria , Haqiq Abdelkrim , Idrissi Leila Loukili
Published: April 2018

This article describes how the landscape of higher education in Morocco has undergone several changes in its organization; hence universities are called upon to strengthen their modes of governance by using new technologies as communication management devices. At the same time, and in a national context of sustainable development, universities are encouraged to adopt a culture of social responsibility like companies and other organizations to promote the notion of citizenship. This article aims to show that the Moroccan university can adopt a sustainable management practice through the establishment of an Information System to ensure and strengthen its governance. The authors focus on the experience of the Moroccan universities in the implementation of the MISSION project which aims at improving the governance of the Moroccan university from a technological point of view.
Re-Floatable Towed Production Systems for Small Pool Development
Authors: Goodlad M. , Hopkins D. , Hendawy M.
Published: April 2018

The Re-floatable Towed Production System Program was instigated to develop a methodology for re-floating, re-positioning and re-installation of a subsea system for marginal fields/small pool developments.

The Towed Production System incorporates either small or large subsea processing manifolds/towheads at the ends, connected together with a Pipeline Bundle. This provides a complete subsea system installed in a single offshore operation.

When installed, a towed production system is ballasted for added on-bottom weight to withstand operational, environmental, and trawling impact loads. To achieve this weight the annulus of the bundle is filled with treated seawater while the main structural members of the towheads are filled with a combination of barite slurry and seawater. This paper will examine the methodology to remove this added ballast in order to re-float the entire system.

The ability to re-float a towed production system unlocks the notion of re-using subsea infrastructure. While historically Pipeline Bundles have shown to be configurable for specific field applications, a standardization of the Pipeline Bundle and integration of subsea processing, as used within this study, can enable the asset to be used over multiple field locations. This includes, but is not limiting to, the use as a development tool for small field exploitation. This will add value to the system as a cost-effective solution for subsea field developments.

A key to the re-use of subsea infrastructure is integrity monitoring, including the demonstration that after re-positioning the product it is fit for purpose with sufficient remaining design life. The paper will also detail the related development work conducted on fibre optic monitoring within the Pipeline Bundle section.
I3P HPHT Checklist for Design Minimum Acceptance Criteria
Authors: Andampour Jay , Hoefler John
Published: April 2018

For decades the design methodology for the development of conventional (surface) and unconventional (subsea) drilling and completion equipment has been utilizing very conservative (non-optimized) and inconsistent approaches.

As oil and gas technology advances into deepwater and high-pressure high-temperature (HPHT) environments, the demands on the equipment's design integrity, efficiency, optimization, and safety have significantly increased, since failures and the associated recovery processes could be very expensive. It is the original equipment manufacturer's (OEM) responsibility to establish high confidence that the operator's assets and businesses are safe, sustainable, and dependable.

The oil and gas industry uses applicable American Society of Mechanical Engineering (ASME) standards, American Petroleum Institute (API) standards, operator's functional specification, and Bureau of Safety and Environmental Enforcement (BSEE) regulation as guidance for product design and development, and their acceptance criteria define the limits placed on characteristics of material, products, and services. Material selection/testing, design verification analysis, and design validation testing establish what standards are used to evaluate every aspect of the equipment design, testing, and manufacturing.

The purpose of the BSEE guidance document is to present conditions under which approval may be granted for the use of well completion and well control equipment that is capable of performing in a deepwater and/or HPHT environment.

The API 17TR8 serves as a nonmandatory technical report guideline for HPHT equipment, specifically for subsea applications.

API standards were intended to adopt the design methodology from the ASME Boiler and Pressure Vessel Code (BPVC), Section VIII, Divisions 2 and 3, which has been used in the oil and gas industry since the 15th edition of API Specification 6A published in 1986.

For example, the original API 6A adopted a design stress intensity of two-thirds of the minimum specified yield strength and a membrane stress intensity of 83% of the minimum specified yield strength. API 6X/17D and 16A adopted their own acceptance design criteria independent of each other and ASME VIII, Division 2. The independent third party (I3P) consequently decided to develop an I3P HPHT Checklist for the Design Minimum Acceptance Criteria to clarify those issues by identifying any deficiencies existing among API standards and to provide a methodology consistent with ASME VIII, Divisions 2 and 3, 2013.