bluuebunny/crossref_metadata_2025 huggingface dataset:
Recent Advances and New Challenges: Two-Dimensional Metal–Organic Framework and Their Composites/Derivatives for Electrochemical Energy Conversion and Storage
Authors: Nivetha Ravi , Sharma Sushant , Jana Jayasmita , Chung Jin Suk , Choi Won Mook , Hur Seung Hyun
Published: February 2023

Metal–organic frameworks (MOFs), as a new generation of intrinsically porous extended crystalline materials formed by coordination bonding between the organic ligands and metal ions or clusters, have attracted considerable interest in many applications owing to their high porosity, diverse structures, and controllable chemical structure. Recently, 2D transition-metal- (TM-) based MOFs have become a hot topic in this field because of their high aspect ratio derived from their large lateral size and small thickness, as well as the advantages of MOFs. Moreover, 2D TM-based MOFs can act as good precursors to construct heterostructures with high electrical conductivity and abundant active sites for a range of applications. This review comprehensively introduces the widely adopted synthesis strategies of 2D TM-based MOFs and their composites/derivatives. In addition, this paper summarizes and highlights the recent advances in energy conversion and storage, including the hydrogen evolution reaction, oxygen evolution reaction, oxygen reduction reaction, CO2 reduction reaction, urea oxidation reaction, batteries, and supercapacitors. Finally, the challenges in developing these intriguing 2D layered materials and their composites/derivatives are examined, and the possible proposals for future directions to enhance the energy conversion and storage performance are reviewed.
Prediction and Evaluation of Bioactive Properties of Cowpea Protein Hydrolysates
Authors: Martin Alain Mune Mune
Published: February 2023

Cowpea protein hydrolysates were prepared using thermolysin, alcalase, and trypsin and analysed for bioactive properties, and then, the release of bioactive peptides was investigated in silico. It was found that the degree of hydrolysis reached 48% after 24 h hydrolysis with alcalase. The hydrolysate prepared using alcalase showed higher ACE inhibitory (62%) and DPPH scavenging activity (19%). SDS-PAGE analysis revealed that vignin was the major protein in cowpea protein isolate. In silico analysis indicated the presence of potential bioactive peptides with potent bioactivity in the primary structure of proteins. The 3D structure of proteins was built, upon which bioactive peptides were mapped using their location in the primary structure. The secondary structure and solvent accessible surface around each bioactive peptide were then calculated. On this basis, the higher degree of hydrolysis and bioactive properties of cowpea protein hydrolysate prepared by alcalase were explained, and structural factors influencing the release of bioactive peptides were investigated.
Impact of Data Partitioning to Improve Prediction Accuracy for Remaining Useful Life of Li-Ion Batteries
Authors: Kim Joonchul , Kim Eunsong , Park Jung-Hwan , Kim Kyoung-Tak , Park Joung-Hu , Kim Taesic , Min Kyoungmin
Published: February 2023

Predicting the remaining useful life (RUL) of a battery is critical to ensure the safe management of its manufacture and operation. In this study, a comprehensive investigation of the effect of data partitioning methods on RUL prediction was performed. To confirm the generality and transferability, the charge–discharge information of cathode materials with different chemical elements was adopted from previous research, including lithium iron phosphate, lithium nickel cobalt aluminum oxide, and lithium nickel cobalt manganese oxide cells. Among the partitioning procedures, the method of adding predicted data from the surrogate model to the training set exhibited the best accuracy, with an average mean absolute error (MAE) of 47 cycles. In contrast, the slide BOX method, which only used certain cycles before the test set as the training set, exhibited the worst MAE value of 60 cycles. In conclusion, the proposed data partitioning method could be implemented to predict the RUL of batteries to develop next-generation cathode materials with improved performance and stability, shorten the quality assessment time, and achieve stable predictive maintenance.
Reasons for Adding Different Tastes: An Example of Sprinkling Salt on Watermelon and Its Relation to Subjective Taste Perception, Taste Preference, and Autistic Traits
Authors: Chen Na , Watanabe Katsumi , Kobayakawa Tatsu , Wada Makoto
Published: February 2023

Each basic taste can be perceived differently due to stored knowledge and differences in receptor properties. Depending on how these tastes are perceived, eating behavior may change. In this study, we examined the relationships between subjective feelings of taste perception, taste preferences, and autistic traits with the behavior of adding flavor to food using an example of sprinkling salt on watermelon. From an online questionnaire survey among a general Japanese population, we found that salty and sour tastes could be subjectively perceived more quickly than sweet and umami tastes, in line with our expectations. Moreover, the hedonic responses to watermelon with salt were negatively correlated with a preference for bitter taste, i.e., those participants who dislike bitter taste sensations tended to enjoy watermelon with salt more. There was no correlation between the hedonic response to watermelon with salt and the subjective feeling of taste perceptions and autistic traits and no correlation between autistic traits, and the subjective feeling of taste perceptions and taste preferences. These results suggest that adding different tastes could be influenced by taste preferences; thus, the addition of a different taste was thought to be related to an unconscious motivation to reduce bitterness.
Targeting Glutamine Metabolism with a Novel Na+/K+-ATPase Inhibitor RX108 in Hepatocellular Carcinoma
Authors: Wei Daoyan , Chen Dongmei , Mou Hongyuan , Chakraborty Sharmistha , Wei Bo , Tan Lin , Lorenzi Philip L. , Qian Xiangping , Yang Peiying
Published: February 2023

The poor prognosis and limited therapeutic options for human hepatocellular carcinoma (HCC), the most common form of liver cancer, highlight the urgent need to identify novel therapeutic modalities. Here, we describe the antitumor activity and underlying molecular mechanisms of a novel Na+/K+-ATPase inhibitor RX108 in human HCC cells and its xenograft model. RX108 dose-dependently inhibited HCC cell proliferation in vitro and tumor growth in a xenograft mouse model, and that the inhibition was associated with induction of apoptosis. Mechanistically, RX108 significantly downregulated alanine serine cysteine transporter 2 (ASCT2) protein expression and reduced glutamine and glutamate concentration in HCC cells and tumors. In addition, RX108 exposure led to a significant decrease in cell energy metabolism in Huh7 and Hep3B cells, including decreased levels of glutathione, NADH, NADPH, and mitochondrial respiration oxygen consumption rate. Furthermore, HCC cells exhibited evidence of glutamine addiction; the antiproliferative effect of RX108 was dependent on glutamine transport. Clinically, elevated ASCT2 mRNA expression in HCCs was associated with unfavorable survival. Taken together, these findings reveal a novel approach to target glutamine metabolism through inhibiting Na+/K+-ATPase and provide a rationale for using RX108 to treat HCC in patients whose tumors express ASCT2 at high levels. RX108 is currently under clinical development.
Adult Low-Hypodiploid Acute Lymphoblastic Leukemia Evolves fromTP53-Mutated Clonal Hematopoiesis
Authors: Saiki Ryunosuke , Ogawa Seishi
Published: February 2023

Low-hypodiploid acute lymphoblastic leukemia (LH-ALL) in both children and adults is characterized by biallelic TP53 alterations in virtually all cases. However, in contrast to a common germline origin of the TP53 mutations in pediatric cases, those in adult cases are mostly somatic and are derived from age-related clonal hematopoiesis (ARCH), highlighting the role of TP53-mutant ARCH in the development not only of myeloid leukemogenesis but also of LH-ALL in aged populations.

See related article by Kim et al., p. 134 (4).
Analysis of N-linked Glycan Alterations in Tissue and Serum Reveals Promising Biomarkers for Intrahepatic Cholangiocarcinoma
Authors: Ochoa-Rios Shaaron , Blaschke Calvin R.K. , Wang Mengjun , Peterson Kendell D. , DelaCourt Andrew , Grauzam Stéphane Elie , Lewin David , Angel Peggi , Roberts Lewis R. , Drake Richard , Mehta Anand S.
Published: February 2023

There is an urgent need for the identification of reliable prognostic biomarkers for patients with intrahepatic cholangiocarcinoma (iCCA) and alterations in N-glycosylation have demonstrated an immense potential to be used as diagnostic strategies for many cancers, including hepatocellular carcinoma (HCC). N-glycosylation is one of the most common post-translational modifications known to be altered based on the status of the cell. N-glycan structures on glycoproteins can be modified based on the addition or removal of specific N-glycan residues, some of which have been linked to liver diseases. However, little is known concerning the N-glycan alterations that are associated with iCCA. We characterized the N-glycan modifications quantitatively and qualitatively in three cohorts, consisting of two tissue cohorts: a discovery cohort (n = 104 cases) and a validation cohort (n = 75), and one independent serum cohort consisting of patients with iCCA, HCC, or benign chronic liver disease (n = 67). N-glycan analysis in situ was correlated to tumor regions annotated on histopathology and revealed that bisected fucosylated N-glycan structures were specific to iCCA tumor regions. These same N-glycan modifications were significantly upregulated in iCCA tissue and serum relative to HCC and bile duct disease, including primary sclerosing cholangitis (PSC) (P < 0.0001). N-glycan modifications identified in iCCA tissue and serum were used to generate an algorithm that could be used as a biomarker of iCCA. We demonstrate that this biomarker algorithm quadrupled the sensitivity (at 90% specificity) of iCCA detection as compared with carbohydrate antigen 19-9, the current “gold standard” biomarker of CCA.

Significance:

This work elucidates the N-glycan alterations that occur directly in iCCA tissue and utilizes this information to discover serum biomarkers that can be used for the noninvasive detection of iCCA.
Defining Biventricular Abnormalities by Cardiac Magnetic Resonance in Pre-Dialysis Patients with Chronic Kidney Disease
Authors: Qi Li , Zhi Beibei , Zhang Jun , Zhang Lingyan , Luo Song , Zhang Longjiang
Published: February 2023

Introduction: The aim of the study was to investigate biventricular structural and functional abnormalities in pre-dialysis patients across stages of chronic kidney disease (CKD) by cardiac magnetic resonance (CMR). Methods: Fifty-one CKD patients with CMR exams were retrospectively analyzed. Patients were divided into three groups according to estimated glomerular filtration rate (eGFR): CKD 1 group (patients with normal eGFR≥90 mL/min/1.73 m2, n = 20), CKD 2-3 group (patients with eGFR< 90 to ≥30 mL/min/1.73 m2, n = 14), and CKD 4-5 group (patients with eGFR<30 mL/min/1.73 m2, n = 17). Twenty-one age- and sex-matched healthy controls (HC) were recruited. CMR-derived left ventricular (LV) and right ventricular (RV) structural and functional measures were compared. Association between CMR parameters and clinical measures was assessed. Results: There was an increasing trend in RV mass index (RVMi) and LV mass index (LVMi) with the occurrence and development of CKD from HC group to CKD 4-5 group although no significant difference was observed between CKD 1 group and HC group. LV global radial strain and LV global circumferential strain dropped and native T1 value elevated significantly in CKD 4-5 group compared with the other three groups (all p < 0.05), while RV strain measures, RV ejection fraction, and LV ejection fraction showed no significant difference among 4 groups (all p > 0.05). Elevated LV end-diastolic volume index (β = 0.356, p = 0.016) and RV end-systolic volume index (β = 0.488, p = 0.001) were independently associated with RVMi. Increased systolic blood pressure (β = 0.309, p = 0.004), LV end-systolic volume index (β = 0.633, p < 0.001), and uric acid (β = 0.261, p = 0.013) were independently associated with LVMi. Meanwhile, serum phosphorus (β = 0.519, p = 0.001) was independently associated with native T1 value. Conclusion: In pre-dialysis CKD patients, left and right ventricular remolding has occurred. RVMi and LVMi were the first changed CMR indexes in the development of CKD when eGFR began to drop. Because fluid volume overload was the independent risk factor for RVMi and LVMi increase, reasonable controlling fluid volume overload may slow down the progression of biventricular remolding and may reduce related cardiovascular disease risk.
Maternal Outcomes Among Pregnant Women With Congenital Heart Disease–Associated Pulmonary Hypertension
Authors: Zhang Qian , Zhu Fang , Shi Guocheng , Hu Chen , Zhang Weituo , Huang Puzhen , Zhu Chunfeng , Gu Hong , Yang Dong , Li Qiangqiang , Niu Yonghua , Chen Hao , Ma Ruixiang , Pan Ziyi , Miao Huixian , Zhang Xin , Li Genxia , Tang Yabing , Qiao Guyuan , Yan Yichen , Zhu Zhongqun , Zhang Hao , Han Fengzhen , Li Yanna , Lin Jianhua , Chen Huiwen
Published: February 2023

Background:

Studies focused on pregnant women with congenital heart disease (CHD)–associated pulmonary hypertension (PH) are scarce and limited by small sample sizes and single-center design. This study sought to describe the pregnancy outcomes in women with CHD with and without PH.

Methods:

Outcomes for pregnant women with CHD were evaluated retrospectively from 1993 to 2016 and prospectively from 2017 to 2019 from 7 tertiary hospitals. PH was diagnosed on the basis of echocardiogram or catheterization. The incidence of maternal death, cardiac complications, and obstetric and offspring complications was compared for women with CHD and no PH, mild, and moderate-to-severe PH.

Results:

A total of 2220 pregnant women with CHD had completed pregnancies. PH associated with CHD was identified in 729 women, including 398 with mild PH (right ventricle to right atrium gradient 30–50 mm Hg) and 331 with moderate-to-severe PH (right ventricle to right atrium gradient >50 mm Hg). Maternal mortality occurred in 1 (0.1%), 0, and 19 (5.7%) women with CHD and no, mild, or moderate-to-severe PH, respectively. Of the 729 patients with PH, 619 (85%) had CHD-associated pulmonary arterial hypertension, and 110 (15%) had other forms of PH. Overall, patients with mild PH had better maternal outcomes than those with moderate-to-severe PH, including the incidence of maternal mortality or heart failure (7.8% versus 39.6%;
P
<0.001), other cardiac complications (9.0% versus 32.3%;
P
<0.001), and obstetric complications (5.3% versus 15.7%;
P
<0.001). Brain natriuretic peptide >100 ng/L (odds ratio, 1.9 [95% CI, 1.0–3.4],
P
=0.04) and New York Heart Association class III to IV (odds ratio, 2.9 [95% CI, 1.6–5.3],
P
<0.001) were independently associated with adverse maternal cardiac events in pregnancy with PH, whereas follow-up with a multidisciplinary team (odds ratio, 0.4 [95% CI, 0.2–0.6],
P
<0.001) and strict antenatal supervision (odds ratio, 0.5 [95% CI, 0.3–0.7],
P
=0.001) were protective.

Conclusions:

Women with CHD-associated mild PH appear to have better outcomes compared with women with CHD-associated moderate-to-severe PH, and with event rates similar for most outcomes with women with CHD and no PH. Multimodality risk assessment, including PH severity, brain natriuretic peptide level, and New York Heart Association class, may be useful in risk stratification in pregnancy with PH. Follow-up with a multidisciplinary team and strict antenatal supervision during pregnancy may also help to mitigate the risk of adverse maternal cardiac events.
Rethinking Menopausal Hormone Therapy: For Whom, What, When, and How Long?
Authors: Cho Leslie , Kaunitz Andrew M. , Faubion Stephanie S. , Hayes Sharonne N. , Lau Emily S. , Pristera Nicole , Scott Nandita , Shifren Jan L. , Shufelt Chrisandra L. , Stuenkel Cynthia A. , Lindley Kathryn J. ,   for the ACC CVD in Women Committee
Published: February 2023

Menopausal hormone therapy (HT) was widely used in the past, but with the publication of seminal primary and secondary prevention trials that reported an excess cardiovascular risk with combined estrogen-progestin, HT use declined significantly. However, over the past 20 years, much has been learned about the relationship between the timing of HT use with respect to age and time since menopause, HT route of administration, and cardiovascular disease risk. Four leading medical societies recommend HT for the treatment of menopausal women with bothersome menopausal symptoms. In this context, this review, led by the American College of Cardiology Cardiolovascular Disease in Women Committee, along with leading gynecologists, women’s health internists, and endocrinologists, aims to provide guidance on HT use, including the selection of patients and HT formulation with a focus on caring for symptomatic women with cardiovascular disease risk.
Comparative Effectiveness of Left Atrial Appendage Occlusion Versus Oral Anticoagulation by Sex
Authors: Zeitler Emily P. , Kearing Stephen , Coylewright Megan , Nair Devi , Hsu Jonathan C. , Darden Douglas , O’Malley A. James , Russo Andrea M. , Al-Khatib Sana M.
Published: February 2023

Background:

The comparative real-world outcomes of older patients with atrial fibrillation (AF) treated with anticoagulation compared with left atrial appendage occlusion (LAAO) may be different from those in clinical trials because of differences in anticoagulation strategies and patient demographics, including a greater proportion of women. We sought to compare real-world outcomes between older patients with AF treated with anticoagulation and those treated with LAAO by sex.

Methods:

Using Medicare claims data from 2015 to 2019, we identified LAAO-eligible beneficiaries and divided them into sex subgroups. Patients receiving LAAO were matched 1:1 to those receiving anticoagulation alone through propensity score matching. The risks of mortality, stroke or systemic embolism, and bleeding were compared between matched groups with adjustment for potential confounding characteristics in Cox proportional hazards models.

Results:

Among women, 4085 LAAO recipients were matched 1:1 to those receiving anticoagulation; among men, 5378 LAAO recipients were similarly matched. LAAO was associated with a significant reduction in the risk of mortality for women and men (hazard ratio [HR], 0.509 [95% CI, 0.447–0.580]; and HR, 0.541 [95% CI, 0.487–0.601], respectively;
P
<0.0001), with a similar finding for stroke or systemic embolism (HR, 0.655 [95% CI, 0.555–0.772]; and HR, 0.649 [95% CI, 0.552–0.762], respectively;
P
<0.0001). Bleeding risk was significantly greater in LAAO recipients early after implantation but lower after the 6-week periprocedural period for women and men (HR, 0.772 [95% CI, 0.676–0.882]; and HR, 0.881 [95% CI, 0.784–0.989], respectively;
P
<0.05).

Conclusions:

In a real-world population of older Medicare beneficiaries with AF, compared with anticoagulation, LAAO was associated with a reduction in the risk of death, stroke, and long-term bleeding among women and men. These findings should be incorporated into shared decision-making with patients considering strategies for reduction in AF-related stroke.
Detection of Cardioembolic Sources With Nongated Cardiac Computed Tomography Angiography in Acute Stroke: Results From the ENCLOSE Study
Authors: Kauw Frans , Velthuis Birgitta K. , Takx Richard A.P. , Guglielmo Marco , Cramer Maarten J. , van Ommen Fasco , Bos Anneloes , Bennink Edwin , Marquering Henk A. , Kappelle L. Jaap , de Jong Hugo W.A.M. , Dankbaar Jan W.
Published: February 2023

Background:

Identifying cardioembolic sources in patients with acute ischemic stroke is important for the choice of secondary prevention strategies. We prospectively investigated the yield of admission (spectral) nongated cardiac computed tomography angiography (CTA) to detect cardioembolic sources in stroke.

Methods:

Participants of the ENCLOSE study (Improved Prediction of Recurrent Stroke and Detection of Small Volume Stroke) with transient ischemic attack or acute ischemic stroke with assessable nongated head-to-heart CTA at the University Medical Center Utrecht were included between June 2017 and March 2022. The presence of cardiac thrombus on cardiac CTA was based on a Likert scale and dichotomized into certainly or probably absent versus possibly, probably, or certainly present. The diagnostic certainty of cardiac thrombus was evaluated again on spectral computed tomography reconstructions. The likelihood of a cardioembolic source was determined post hoc by an expert panel in patients with cardiac thrombus on CTA. Parametric and nonparametric tests were used to compare the outcome groups.

Results:

Forty four (12%) of 370 included patients had a cardiac thrombus on admission CTA: 35 (9%) in the left atrial appendage and 14 (4%) in the left ventricle. Patients with cardiac thrombus had more severe strokes (median National Institutes of Health Stroke Scale score, 10 versus 4;
P
=0.006), had higher clot burden (median clot burden score, 9 versus 10;
P
=0.004), and underwent endovascular treatment more often (43% versus 20%;
P
<0.001) than patients without cardiac thrombus. Left atrial appendage thrombus was present in 28% and 6% of the patients with and without atrial fibrillation, respectively (
P
<0.001). The diagnostic certainty for left atrial appendage thrombus was higher for spectral iodine maps compared with the conventional CTA (
P
<0.001). The presence of cardiac thrombus on CTA increased the likelihood of a cardioembolic source according to the expert panel (
P
<0.001).

Conclusions:

Extending the stroke CTA to cover the heart increases the chance of detecting cardiac thrombi and helps to identify cardioembolic sources in the acute stage of ischemic stroke with more certainty. Spectral iodine maps provide additional value for detecting left atrial appendage thrombus.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT04019483.
A Survey on Automatic Delineation of Radiotherapy Target Volume based on Machine Learning
Authors: Tao Zhenchao , Lyu Shengfei
Published: February 2023

Radiotherapy is one of the main treatment methods for cancer, and the delineation of the radiotherapy target area is the basis and premise of precise treatment. Artificial intelligence technology represented by machine learning has done a lot of research in this area, improving the accuracy and efficiency of target delineation. This article will review the applications and research of machine learning in medical image matching, normal organ delineation and treatment target delineation according to the procudures of doctors to delineate the target volume, and give an outlook on the development prospects.
Field-level differences in paper and author characteristics across all fields of science in Web of Science, 2000–2020
Authors: Andersen Jens Peter
Published: February 2023

With increasing availability of near-complete, structured bibliographical data, the past decade has seen a rise in large-scale bibliometric studies attempting to find universal truths about the scientific communication system. However, in the search for universality, fundamental differences in knowledge production modes and the consequences for bibliometric assessment are sometimes overlooked. This article provides an overview of article and author characteristics at the level of the OECD minor and major fields of science classifications. The analysis relies on data from the full Web of Science in the period 2000–2020. The characteristics include document type, median reference age, reference list length, database coverage, article length, coauthorship, author sequence ordering, author gender, seniority, and productivity. The article reports a descriptive overview of these characteristics combined with a principal component analysis of the variance across fields. The results show that some clusters of fields allow inter-field comparisons, and assumptions about the importance of author sequence ordering, while other fields do not. The analysis shows that major OECD groups do not reflect bibliometrically relevant field differences, and that a reclustering offers a better grouping.
Xerocomellus perezmorenoi (Boletaceae, Boletales), a new edible species from Mexico
Authors: MARTÍNEZ-REYES MAGDALENA , CARRERA-MARTÍNEZ Anaitzi , DE LA FUENTE JAVIER ISAAC , RÍOS-GARCÍA UZZIEL , ORTIZ-LOPEZ IVETTE , AYALA-VÁSQUEZ OLIVIA
Published: February 2023

Xerocomellus perezmorenoi (Boletaceae, Boletales) is described as a new species from Mexico. This species was collected under Abies religiosa in mixed coniferous forest located in three localities (Puebla, Tlaxcala, and State of Mexico) in central Mexico. It is morphologically characterized by its small-sized basidiomata, pileus brown at the center and cream with pink to purple tones at the margin, almost blackish at the center when young, black-brown when mature, pores lilac, peach to salmon when young, yellow citrine at mature; violet or violet-brown color reaction of the context when cut; basidiospores (12–) 15–16 (–17) × 4–5 (–6) µm. Phylogenetic analyses (Maximum likelihood and Bayesian inference) based on multi-locus sequences confirmed X. perezmorenoi is a new species, with biocultural importance due to edibility. Detailed a description, photographs, analyses of phylogenetics, and taxonomic discussions are presented.
Validation of Myristica pushpangadaniana (Myristicaceae)
Authors: KOTTAIMUTHU RAMALINGAM
Published: February 2023

Myristica Gronovius (1755: 141) was established in Flora orientalis and comprises about 172 species, distributed from tropical Asia to western Pacific (POWO 2023). In India, Myristica has seven taxa, among them six endemics. Of these, M. andamanica Hooker (1886: 103) is found only in the Andaman and Nicobar Islands, M. beddomei King (1891: 291) in Western Ghats and Eastern Ghats and M. beddomei King (1891: 291) subsp. sphaerocarpa W.J.deWilde (1997: 152) and M. magnifica Beddome (1872: 268), M. malabarica Lamarck (1791: 162) and M. trobogarii Govind & Dan (2020: 206) are exclusively found only in the Western Ghats.
The Role of Ocean–Atmosphere Interactions in Tropical Cyclone Intensity Predictability
Authors: Li Dian-Yi , Tan Zhe-Min
Published: February 2023

The negative feedback between tropical cyclone (TC) intensity and sea surface temperature (SST) plays an important role in TC development. In this study, ocean–atmosphere coupled and uncoupled ensemble forecasts are conducted to investigate the dynamics of error growth and predictability of TC intensity in an ocean–atmosphere coupled system. For the TC–ocean coupled system, the TC intensity–SST negative feedback is the essential mechanism to reduce the error growth of TC intensity by two routes, and thereby improves the TC intensity predictability. For the first route (atmosphere-limited route), the TC-induced SST cooling slows the intensification rate of the TC and weakens the final TC intensity, thereby reducing the error growth of TC intensity. In this route, the TC intensity spread is limited by the magnitude of TC intensity, while SST can be regarded as an environmental forcing. For the second route (atmosphere–ocean mutually influenced route), the interaction between the TC intensity spread and SST spread is dominant. The increasing TC intensity spread could lead to an increase in SST cooling spread, and then reduce the TC intensity spread through the negative feedback. In other words, the more (less) intense TC produces stronger (weaker) SST cooling, and thereby limits (enhances) further TC intensification in an ensemble forecast. In the second route, initial ocean temperature uncertainty could suppress the TC intensity spread reduction.

Significance Statement

Tropical cyclones force the sea surface and can lead to its cooling. This cooled sea surface can then suppress tropical cyclone intensification. The purpose of this study is to better examine the influence of such an interaction between a tropical cyclone and the ocean on tropical cyclone forecasts. We explore how accurately representing the interaction can improve the capacity to forecast tropical cyclone intensity. Given that many weather forecasting centers have considered this interaction in their models, this study should help them to understand and improve their forecasts.
Deep Learning–Based Prediction of Kuroshio Path South of Japan
Authors: Wu Xiaobo , Han Guijun , Li Wei , Shao Qi , Cao Lige
Published: February 2023

Variation of the Kuroshio path south of Japan has an important impact on weather, climate, and ecosystems due to its distinct features. Motivated by the ever-popular deep learning methods using neural network architectures in areas where more accurate reference data for oceanographic observations and reanalysis are available, we build four deep learning models based on the long short-term memory (LSTM) neural network, combined with the empirical orthogonal function (EOF) and complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN), namely, the LSTM, EOF–LSTM, CEEMDAN–LSTM, and EOF–CEEMDAN–LSTM. Using these models, we conduct long-range predictions (120 days) of the Kuroshio path south of Japan based on 50-yr ocean reanalysis and nearly 15 years of satellite altimeter data. We show that the EOF–CEEMDAN–LSTM performs the best among the four models, by attaining approximately 0.739 anomaly correlation coefficient and 0.399° root-mean-square error for the 120-day prediction of the Kuroshio path south of Japan. The hindcasts of the EOF–CEEMDAN–LSTM are successful in reproducing the observed formation and decay of the Kuroshio large meander during 2004/05, and the formation of the latest large meander in 2017. Finally, we present predictions of the Kuroshio path south of Japan at 120-day lead time, which suggest that the Kuroshio will remain in the state of the large meander until November 2022.
Symbolic Conflict Resolution and Ingroup Favoritism
Authors: Martínez Sergi , Valentim Vicente , Dinas Elias
Published: February 2023

What are the domestic consequences of symbolic conflict resolution? We isolate the effect of symbolic conflict by looking into a dispute with no material stakes (for one side), but high symbolic ones: the Prespa Agreement, which ended the dispute on the name of FYROM, thenceforth named North Macedonia. Greeks opposed this name because the ancient Macedonian heritage is central to their national identity. Based on social identity theory, we expect this threat to the group’s distinctiveness to increase nationalist sentiment. Using an original dataset of flags displayed in the façade of buildings in Athens and Thessaloniki, which we compare to Lisbon, we find an increase in national flags in the Greek cities after the Agreement. The effect is stronger in Thessaloniki, Greek Macedonia’s capital, where the identity threat was more pronounced. We also find that the treaty shifted voters to the right, especially those residing in the region of Macedonia.
Lived Experience of Caring for Dying Muslim Patients in Emergency Room: A Phenomenological Study
Authors: Bigdeli Shamloo Marzieh Beigom , Elahi Nasrin , Zarea Kourosh
Published: February 2023

Death is a natural part of life, which mostly occurs in the ER. This study described the meaning of nurses’ lived experience of caring for critical and dying patients in the ERs. In this qualitative study, 13 nurses who was purposefully selected. Data were collected using in-depth individual interviews. Data analysis used van Manen’s hermeneutic phenomenological approach. The experiences of caring for the dying patient were divided into two parts: experiences in patients with acute and chronic problems. In patients with acute problems, four themes were extracted: fight to the death, no time for palliative and spiritual care, lacking support for the family, no privacy for peaceful death. In patients with acute problems, four themes were extracted: Facilitating a peaceful death, Allocating time for palliative and spiritual care, support for the family, Attention to privacy. Therefore, attention should be paid to the fields of care and its inadequacies.
2023 NEA Presidential Address: Economic Research and Policy as Tools for Racial Economic Justice
Authors: Wilson Valerie R.
Published: February 2023

Statistical analysis often reveals that racial identity is a measurable, significant, and persistent predictor of economic outcomes. Persistent racial disparities in unemployment and wages are defining features of the U.S. labor market and as such, provide some of the most compelling evidence of structural racism in this country. In her 2023 NEA Presidential Address, Wilson discusses decades of data and research in support of this conclusion and identifies some of the institutions that play an important role in facilitating racial economic justice.
Intelligent electric vehicle trajectory tracking control algorithm based on weight coefficient adaptive optimal control
Authors: Li Teng , Ren Hongjuan , Li Cong
Published: February 2023

The track tracking effect of intelligent vehicle directly affects the safety of vehicle and passengers. In the process of intelligent vehicle track tracking, the track tracking accuracy is related to many factors such as track curvature, road friction coefficient, and longitudinal speed change. In this paper, a new lateral and longitudinal coupling control algorithm is proposed. Based on the vehicle dynamics model and the optimal control theory, combined with the fuzzy control theory, the Fuzzy Linear Quadratic Regulator (FLQR) lateral optimal controller is designed, and feed-forward control and predictive controller are added. According to the real-time tracking lateral error and fuzzy control algorithm fed back by the system, the weight coefficient of the lateral displacement deviation in the cost function is dynamically adjusted; considering the coupling effect of lateral and longitudinal controllers of vehicle trajectory tracking control, a model predictive control (MPC) longitudinal speed controller is designed based on MPC theory, considering acceleration constraint and acceleration variation constraint, and taking lateral stability as evaluation index. A joint simulation platform is built based on CarSim and Simulink. The simulation results show that the designed lateral and longitudinal coupling controller of FLQR + MPC has better track tracking accuracy and can improve the driving stability of the vehicle; finally, the tracking effect of the designed algorithm is verified by real vehicle experiments. The maximum error of the designed controller algorithm in real vehicle tracking is 0.56 m, and the tracking effect is good.
Sinonasal Schwannomas: Imaging Findings and Review of Literature
Authors: Brahmbhatt Pavan , Kumar Tushar , Bhatt Alok A. , Vibhute Prasanna , Patel Vishal , Desai Amit , Gupta Vivek , Agarwal Amit
Published: February 2023

Objective

Schwannomas are common nerve sheath tumors and may occur anywhere in the body. 4% of head and neck schwannomas occur in the sinonasal cavity, and fewer yet have an intracranial component, making these presentations extremely rare. Furthermore, schwannomas present with nonspecific imaging signs and can only be definitively differentiated via histopathologic review, leading to misdiagnosis as various nasal tumors. We aim to conduct a review of published literature on sinonasal schwannomas with and without intracranial extension and provide additional case representations.

Methods

A literature review was conducted using the PubMed Database with the terms “sinonasal schwannoma,” “intracranial,” “anterior skull base,” and “schwannoma.” Results were reviewed, and additional cases identified were referenced and included in the study. Inclusion criteria were any case with intracranial extension of the schwannoma. There were no exclusion criteria. Review data was compiled into Excel and used for data analysis and comparison. Additionally, a search was done within our institution to identify additional cases of sinonasal schwannoma.

Results

We identified 17 cases of sinonasal schwannoma with intracranial extension, five from our institution and twelve from literature. Analysis revealed: 8 females (47%), 9 males (53%), 9 patients presented with headaches (53%), 6 patients presented with anosmia (35%), 4 patients presented with nasal obstruction (24%), and 2 patients with no symptoms (12%). Mean age and median were 39.4 ± 10.1 and 40, respectively. For treatment, 4 patients underwent endoscopic resection (24%), 11 underwent craniotomy (65%), and data was unavailable for 2 patients. Post-treatment complications occurred in 6 patients, 5 had CSF leaks (29%) and 1 had a hematoma (6%).

Conclusion

We identified and discussed 17 cases of sinonasal schwannoma with intracranial extension. We hope our review provides insight for clinicians to maintain schwannoma as a potential differential when evaluating nasal and anterior skull base masses.
Infrared Thermography, Intratendon Vascular Resistance, and Echotexture in Athletes with Patellar Tendinopathy: A Cross-Sectional Study
Authors: Molina-Payá Francisco J. , Ríos-Díaz José , Carrasco-Martínez Francisco , Martínez-Payá Jacinto J.
Published: February 2023

Ultrasonographic signs of tendinopathies are an increase in thickness, loss of alignment in collagen fibers and the presence of neovascularization. Nevertheless, analysis of intratendinous vascular resistance (IVR) can be more useful for understanding the physiological state of the tissue. To show thermal, echotextural, and Doppler signal differences in athletes with patellar tendinopathy and controls. Twenty-six athletes with patellar tendinopathy (PT) participants (30.1 years; SD = 9.0 years) and 27 asymptomatic athletes (23.3 years; SD = 5.38 years) were evaluated with thermographic and Doppler ultrasonography (DS). Area of Doppler signals (DS), echotextural parameters (echointensity and echovariation) and IVR were determined by image analysis. The statistical analysis was performed by Bayesian methods and the results were showed by Bayes Factor (BF10: probability of alternative hypothesis over null hypothesis), and Credibility intervals (CrI) of the effect. The absolute differences of temperature (TD) were clearly greater (BF10 = 19) in the tendinopathy group (patients) than in controls. Regarding temperature differences between the affected and healthy limb, strong evidence was found (BF10 = 14) for a higher temperature (effect = 0.53°C; 95% CrI = 0.15°C–0.95°C) and very strong for reduced IVR compared (BF10 = 71) (effect = −0.67; 95% CrI = −1.10 to 0.25). The differences in area of DS (BF10 = 266) and EV (BF10 = 266) were higher in tendinopathy group. TD showed a moderate positive correlation with VISA-P scores (tau-B = .29; 95% CrI = .04–.51) and strong correlation with IVR ( r = −.553; 95%CrI = −.75 to .18). Athletes with patellar tendinopathy showed a more pronounced thermal difference, a larger area of Doppler signal, a lower IVR and a moderately higher echovariaton than controls. The correlation between temperature changes and IVR might be related with the coexistence of degenerative and inflammatory process in PT.
Teacher Support as a Protective Factor? The Role of Teacher Support for Reducing Disproportionality in Problematic Behavior at School
Authors: Bussemakers Carlijn , Denessen Eddie
Published: February 2023

This study investigated whether support from teachers could serve as a protective factor and reduce disproportionality in problematic behavior. Data from the CILS4EU project on 14-year-old European students were used ( N = 18,308). Students reported on their social background (parental resources, migrant background and adverse family risks), experiences of teacher support (academic and social) and problematic behavior (getting angry, acting impulsively and skipping classes). Multilevel regression analyses showed that students’ disadvantageous social background was associated with more problematic behavior. Teacher support had a beneficial effect: academic support from teachers was associated with less problematic behavior for almost all students, while social support reduced problematic behavior among students with low educated parents. Enhancing academic and social support from teachers could thus help reduce educational inequalities by protecting vulnerable students against negative behavioral outcomes.
Image quality using synthetic brain MRI: an age-stratified study
Authors: Zou Mengsha , Zhou Qin , Li Ruocheng , Hu Manshi , Qian Long , Yang Zhiyun , Zhao Jing
Published: February 2023

Background

Synthetic magnetic resonance imaging (MRI) might replace the conventional MR sequences in brain evaluation to shorten scan time and obtain multiple quantitative parameters.

Purpose

To evaluate the image quality of multiple-delay-multiple-echo (MDME) sequence-derived synthetic brain MR images compared to conventional images by considering a multi-age sample.

Material and Methods

Image sets of conventional and synthetic MRI of 200 participants were included. On the basis of the presence of intracranial lesions, the participants were divided into a normal group and a pathological group. Two neuroradiologists compared the anonymous and unordered images. Image quality, artifacts, and diagnostic performance were analyzed.

Results

In the quantitative analysis, comparing with conventional images, MDME sequence-derived synthetic MRI demonstrated an equal/greater signal-to-noise ratio and contrast-to-noise ratio (CNR) in all age groups. Specifically, for participants aged ≤2 years, synthetic T2-fluid-attenuated inversion recovery imaging showed a significantly higher cerebellum gray/white matter CNR ( P < 0.05). In the qualitative and artifact analyses, except for the superior sagittal sinus and cranial nerves, synthetic MRI showed good imaging quality (≥3 points) in all brain structures. On synthetic T1-weighted imaging, high signal intensity within the superior sagittal sinus was found in most of our participants (107/118, 90.7%). No difference was observed between synthetic and conventional MRI in diagnosing the lesions.

Conclusion

MDME sequence-derived synthetic MRI showed similar image quality and diagnostic performance with a shorter acquisition time than conventional MRI. However, the high signal intensity within the superior sagittal sinus on synthetic T1-weighted images requires consideration.
Incidence of Complications and Revision Surgery After High Tibial Osteotomy: A Systematic Review
Authors: Miltenberg Benjamin , Puzzitiello Richard N. , Ruelos Verdinand C.B. , Masood Raisa , Pagani Nicholas R. , Moverman Michael A. , Menendez Mariano E. , Ryan Scott P. , Salzler Matthew J. , Drager Justin
Published: February 2023

Background:

High tibial osteotomy (HTO) is a well-recognized procedure for its effectiveness in treating symptomatic early knee arthritis and malalignment. Although there are numerous systematic reviews evaluating the management and outcomes after HTO, there are few investigations on complications of this procedure.

Purpose:

To systematically review the literature to determine the incidence of intraoperative and postoperative complications associated with medial opening wedge and lateral closing wedge HTOs.

Study Design:

Systematic review; Level of evidence, 4.

Methods:

The Cochrane Database of Systematic Reviews, PubMed, Embase, and MEDLINE databases were queried for studies reporting complications associated with HTO with or without concomitant procedures. Data including patient characteristics, procedure type, concomitant procedures, follow-up time, and postoperative imaging were extracted. Rates of intra- and postoperative complications, reoperations, and conversion to arthroplasty were recorded.

Results:

A total of 71 studies were included for analysis, comprising 7836 patients. The overall intraoperative complication rate during HTO was 5.5% (range, 0%-29.3%), and the overall postoperative complication rate was 6.9% (range, 0%-26.6%). The most common intraoperative complication was lateral hinge fracture (incidence, 9.1%; range, 0%-30.4%) in medially based HTOs and peroneal nerve injury in laterally based HTOs (incidence, 3.2%; range, 0%-8.7%). The overall incidence of neurovascular injury after medially or laterally based HTOs was 1.1% (range, 0%-18.9%). The most common postoperative complication was superficial infection (incidence, 2.2%; range, 0%-13%). Of the included studies, 62 included postoperative radiographic analysis, and among those, the incidence of nonunion was 1.9% (range, 0%-15.5%), loss of correction was 1.2% (range, 0%-34.3%), and implant failure was 1.0% (range, 0%-10.2%). Among studies reporting revision surgeries, the overall reoperation rate was 15.5% (range, 0%-70.7%), with the most common type of reoperation being hardware removal (incidence, 10.0%; range, 0%-60%).

Conclusion:

Intraoperatively, medially based HTOs are associated with a 1 in 11 risk of lateral hinge fracture and laterally based HTOs with a 1 in 30 risk of peroneal nerve injury. Postoperative complication rates in the range of 10% to 15% can be expected, including infection (2.9%), loss of correction (1.2%), and nonunion (1.9%). Patients should also be counseled that the reoperation rate is approximately 15%, with hardware removal being the most common procedure.
Effect of Posterior Malleolar Fixation on Syndesmotic Stability
Authors: Stake Ingrid Kvello , Bryniarski Anna R. , Brady Alex W. , Miles Jon W. , Dornan Grant J. , Madsen Jan Erik , Haytmanek C. Thomas , Husebye Elisabeth Ellingsen , Clanton Thomas O.
Published: February 2023

Background:

Transsyndesmotic fixation with suture buttons (SBs), posterior malleolar fixation with screws, and anterior inferior tibiofibular ligament (AITFL) augmentation using suture tape (ST) have all been suggested as potential treatments in the setting of a posterior malleolar fracture (PMF). However, there is no consensus on the optimal treatment for PMFs.

Purpose:

To determine which combination of (1) transsyndesmotic SBs, (2) posterior malleolar screws, and (3) AITFL augmentation using ST best restored native tibiofibular and ankle joint kinematics after 25% and 50% PMF.

Study Design:

Controlled laboratory study.

Methods:

Twenty cadaveric lower-leg specimens were divided into 2 groups (25% or 50% PMF) and underwent biomechanical testing using a 6 degrees of freedom robotic arm in 7 states: intact, syndesmosis injury with PMF, transsyndesmotic SBs, transsyndesmotic SBs + AITFL augmentation, transsyndesmotic SBs + AITFL augmentation + posterior malleolar screws, posterior malleolar screws + AITFL augmentation, and posterior malleolar screws. Four biomechanical tests were performed at neutral and 30° of plantarflexion: external rotation, internal rotation, posterior drawer, and lateral drawer. The position of the tibia, fibula, and talus were recorded using a 5-camera motion capture system.

Results:

With external rotation, posterior malleolar screws with AITFL augmentation resulted in best stability of the fibula and ankle joint. With internal rotation, all repairs that included posterior malleolar screws stabilized the fibula and ankle joint. Posterior and lateral drawer resulted in only small differences between the intact and injured states. No differences were found in the efficacy of treatments between 25% and 50% PMFs.

Conclusion:

Posterior malleolar screws resulted in higher syndesmotic stability when compared with transsyndesmotic SBs. AITFL augmentation provided additional external rotational stability when combined with posterior malleolar screws. Transsyndesmotic SBs did not provide any additional stability and tended to translate the fibula medially.

Clinical Relevance:

Posterior malleolar fixation with AITFL augmentation using ST may be the preferred surgical method when treating patients with acute ankle injury involving an unstable syndesmosis and a PMF ≥25%.