bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy of Jambu (Seed) as an Antidote in Kuchala Poisoning an Experimental Study
Authors: Kumar Dr. Amit , Kapoor Dr. Ritu , Adlakha Dr. Manoj
Published: October 2022

Abstract: Kuchala (Strychnos nux-vomica) is spinal poison which is also classified as Upavisha in Ayurveda.Various poisons have been described in Ayurveda along with their antidotes. Mode of action of these antidotes is not mentioned in texts. In Ayurvedic literature According to Basavrajeeyam under the heading of Vish-Prativishani, Jambu (seed) have been described to be possessing antidote action which may act by some way to counter toxicity of Kuchala. It is necessary to verify the efficacy of these antidotes on scientific parameters so that it can be useful in emergencies. Objectives: To establish the action and mechanism of Jambu (seed) against toxic effects of Kuchala on albino wistar rats. Methods: albino wistar rats were selected as an animal model and antidote potential of Jambu (seed) against Kuchala is evaluated by measuring convulsions and histopathological reports of brain and spinal cord. Results: Jambu (seed) administration before Kuchala poisoning reduced the toxic effects of Kuchala such as convulsion and histopathological changes in brain and spinal cord. Conclusion: From this study, we can conclude that Jambu (seed) can resist the toxic effects of Kuchala up to some extent.
Fungal Disease Detection in Apple Crops Using Random Forest Model
Authors: Gulzar Tanzeeba , Gupta Ankur
Published: October 2022

Abstract: Disease has always been one of the main reasons for the decline of apple quality and yield, which directly harms the development of agricultural economy. Therefore, precise diagnosis of apple diseases and correct decision making are important measures to reduce agricultural losses and promote economic growth. The forecasting of crop disease is a significant and innovative topic; the debasement in both quality and quantity in the yield of crops is due to various conditions, which in turn alters the economy of countries like India, where a majority of the population hinge on crop and cultivation. It is challenging to keep an eye on disease in plants through conventional approaches, which involve a lot of effort, time, and experience. Automated disease identification of plants is a critical research field. In this paper, focus is laid on how machine learning helps in apple disease detection using various prediction algorithms using weather and disease datasets.
Sexo sin protección: contradicciones y lógicas de acción
Authors: Gómez-Bueno Carmuca , González-Calo Inés , Rodríguez-García-de-Cortázar Ainhoa
Published: October 2022

¿Cuáles son los argumentos contrarios al uso del preservativo manejados por la población de 18 a 25 años residente en Granada? Para responder a esta pregunta se diseñó una investigación cualitativa mediante grupos de discusión. Fueron seis los grupos de discusión realizados, en ellos participaron treinta y nueve jóvenes, segmentados por nivel de estudios, género, orientación sexual y duración de su relación. Los objetivos del artículo son: analizar los imaginarios que condicionan el uso de protección frente a las infecciones de transmisión sexual (condones y barreras de látex) en las relaciones sexuales entre jóvenes de diferentes orientaciones sexuales y comprender las lógicas que contribuyen a dotarlas de sentido. El análisis de los discursos reveló prácticas de cuidados poco consistentes, dificultades para erotizar el uso del condón y ausencia de protección para el sexo entre mujeres. Se identificaron exigencias de género contradictorias y diferentes imaginarios del placer. Finamente, se desvelaron las lógicas de la confianza y del placer como reguladoras de la lógica preventiva del cuidado.
“...When the Russians Came”: Soviet Contacts of Hermann Kasack
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Ebanoidze Igor A.
Published: October 2022

The article is dedicated to the contacts of the German writer Herman Kasack with the Soviet Union. The first contact with the USSR took place in an emergency situation. In April 1945 his house in Potsdam was turned into a headquarters of the advanced guard of the Red Army. Kasack’s visit to Moscow (1959), on the contrary, followed the traditional Soviet rite of hospitality. These two episodes of the German writer’s Soviet contacts were described in detail in Kasack’s non-fictional texts and are a unique chronicle of the mid-twentieth century.
Russian–German Cultural Transfer (the Case of the Publishing House “Suhrkamp”)
Authors:   Russian State University for the Humanities (RSUH), Bakshi Natalia A.
Published: October 2022

The case of the important German publishing house “Suhrkamp” illustrates the attitude towards Russian literature in the post-war Germany. The spreading of Russian literature in “Suhrkamp” was made possible by interpreters and cultural mediators like Gisela Drohla, Hugo Huppert, Wolfgang Kasack and Ilma Rakusa. Complicated relations between them and the editors of the publishing house influenced the selection of Russian books and authors for translation and the publishing strategy towards Russian literature in general.
Russian Uncensored Poetry and German Concretism: Between Creative Reception and Reflection
Authors:   HSE University, Pavlovets Mikhail G.
Published: October 2022

Representatives of the Soviet underground who chose to be autonomous from the censored literary and artistic environment in the USSR, regarded their position as a “double separation” from the pre-revolutionary and revolutionary culture of the Soviet Russia of the 1920s on the one hand and from the world culture on the other hand. According to many of them, their mission was not only to comprehend but also to overcome the separation, to reconnect with the past culture of their country and to get synchronized with the modern artistic and literary processes. An important role in the process of synchronization was played by the fact that the uncensored writers of the second half of the 20th century got acquainted with concrete poetry, especially German poetry, which started penetrating the “Iron Curtain” with the anthologies of concrete poetry and some translations into Russian which were primarily made to discredit “the bourgeois art”. One of the most difficult tasks for the researchers of these processes is to distinguish between the examples of direct influence of concrete poetry texts and manifests in the works of the unofficial Soviet authors and those reflecting their own approach, which was typologically similar to the one used by their Western colleagues and produced similar independent results. The article analyzes various forms of both creative reception and independent search for approaches to concrete poetry used by uncensored poets of the Soviet period, including Leningrad poets of the “Malaya Sadovaya” circle (V. Erl, L. Aronzon) “Lianozovo School” (G. Sapgir, I. Kholin, Vs. Nekrasov) as well as the authors whose works were published in 1985 in the first anthology of Russian concrete poetry (A. Ocheretyanskiy, V. Barskiy, V. Bakhchanyan, A. Kondratov and others).
The Schwank of the Russian Germans: Development of the German Genre (Based on the Example of Edmund Günther`s work)
Authors:   Russian State University for the Humanities, Seifert Elena I.
Published: October 2022

The literary genre of Schwank is analyzed on the basis of the poetry by the most famous Russian-German Schwank author Edmund Günther.
Heinrich Heine and Timur Kibirov: the Formula of Similarity
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Zuseva-Özkan Veronika B.
Published: October 2022

The article examines the reflection of Heinrich Heine’s poetry and persona in the work of the contemporary Russian poet Timur Kibirov who was greatly influenced by Heine though not through original texts but through numerous translations into Russian (so called “Russian Heine”). This influence is acknowledged by Kibirov in his poem in prose Dead Crones and demonstrated in this article on several levels: the level of direct references to Heine; the level of individual quotes and allusions; the level of fundamental principles of poetics and worldview. The creative reception of Heine by Kibirov is highly unusual and goes far beyond the traditional attitude toward the German poet: Heine is commonly perceived as a rebel, a sufferer and the last Romantic poet whose writings highlight ironic dissonances, while in Kibirov’s creations he appears as a harmonic personality, and his poetry — as a kind of vaccine against decadent worldview and “Romanticism”.
Grimaces of History: Personality and Works of Paul Ernst in Soviet and Post–Soviet Academic Discourse
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Kudryavtseva Tamara V.
Published: October 2022

The article traces the history of the scientific reception of the personality and works of the German writer Paul Ernst in Soviet and post-Soviet academic discourse. The reasons for the lack of interest of Germanists in this figure are explained.
“My” Heiner Müller
Authors:   State Institute for Art Studies of the Ministry of Culture of the Russian Federation, Koljazin Vladimir F.
Published: October 2022

The article attempts to describe the work and poetics of Heiner Müller, one of the most significant German playwrights of the second half of the 20th century. The article of Vladimir Koljazin, who was friends with the playwright for many years, is written in the form of memoirs and notes about their meetings both in Germany and in Russia. Besides the phenomenon of Heiner Müller’s theater, this paper considers the problem of translation of his plays into Russian and the publication of a collection of his works.
Russian Poetry in Museum der modernen Poesie (1960/2002) by Hans Magnus Enzensberger: Translation as “a Dialect of the Universal Language of Poetry”
Authors:   Togliatti State University, Andreiushkina Tatiana N.
Published: October 2022

The article deals with a part of the anthology of Hans M. Enzensberger, which is dedicated to Russian poets Velimir Khlebnikov, Vladimir Mayakovski, Sergey Yesenin, Leonid Pasternak, Osip Mandelstam. We also analyze the Afterword to Museum, where the author sets out his views on world poetry of the first half of the 20th century, in particular on the avant-garde poetry. The second part of the article is dedicated to the analysis of Enzensberger`s novel Tumult (2014, transl. 2018) and his attitude to Russian poetry.
Plan Maestro de Educación Ambiental: Costa Rica
Authors: Estrella Guier Serrano
Published: October 2022

El Plan Maestro de Educación Ambiental para Costa Rica fue un proyecto ideado por Mario Boza y Álvaro Ugalde (considerados los padres de los parques nacionales de este país). Se formuló en los años 1987-88, desde la Fundación    Neotrópica y con apoyo de la fundación Mac Arthur de los Estados Unidos. Fue el primer esfuerzo del país con financiamiento específico para impulsar la educación ambiental a todo nivel. El plan de trabajo incluyó diversas etapas con el fin de obtener la información necesaria para la formulación del plan de acción. Se contó con apoyo gubernamental, mediante la creación por decreto ejecutivo de una Comisión Nacional de Educación Ambiental, encargada de impulsar su ejecución por parte de las instancias correspondientes.
Behavior of HF and (HF)2 inside a fullerene cage: A benchmarking study using different density functionals
Authors: Poddar Arpita , CN Ramachandran , Chattaraj Pratim
Published: October 2022

A proper benchmarking on the properties of HF and its dimer inside C60
using density functional theory (DFT) based approaches is presented. For
this purpose, 10 different DFT functionals following Jacob’s Ladder have
been chosen. Geometrical parameters, viz., bond length, bond angle,
etc., and dipole moment have been computed. Two types of orientations,
viz., L-shaped and anti-parallel of (HF)2 inside C60 are considered, the
latter with an extremely short hydrogen bond. HF bond lengths are
elongated upon encapsulation in comparison to its free state analogue.
The calculated stability of HF@C60 is functional dependent whereas,
(HF)2C60 is thermodynamically unstable for all the functionals. The
kinetic stability of (HF)2@C60 is observed through ADMP simulation at
300K temperature. The red shift in HF stretching frequencies is noticed
in all cases. NCI analysis exhibits a non-covalent type interaction
between HF dimer and the C60 cage. The total interaction energy is found
to be negative for HF@C60. EDA analysis showed a high value of repulsive
ΔEpauli which makes the (HF)2@C60 system unstable except for the
functional BP86-D3 of GGA family. Furthermore, QTAIM analysis is
performed and confirmed the presence of (3, -1) bond critical point
along the hydrogen bond region for L-shaped (HF)2C60.
Cerebral infarction as initial manifestation of meningovascular neurosyphilis in an immunocompetent patient - a case report with long term follow-up
Authors: Batinić Davor , Antulov Ronald , Klupka-Sarić Inga , Ivanković Anita , Jurina Renata , Vidaković Marijana Karlović , Drlje Ivana Talić , Arapovic Jurica
Published: October 2022

Objective: To present 29-year-old patient with neurosyphilitic changes
characterized by multiple acute ischemic brain strokes along with
significant narrowing of several large intracranial arteries. After
treatment of patient with ceftriaxone for 14 days following benzathine
benzylpenicillin weekly for additional three weeks, meningovascular
changes regressed.
The Quality and Safety of Sedation and Monitoring in Adults Undergoing Non-Operative Transesophageal Echocardiography
Authors: Kersey Cooper , Lele Abhijit V. , Johnson Matthew N. , Pattock Andrew , Liu Linda , Huang Gary S. , Kirkpatrick James , Mazimba Sula , Jobarteh Sulayman , Kwon Younghoon
Published: October 2022

Background: Sedation is an essential component of the
transesophageal echocardiography (TEE) procedure for patient comfort.
Utilization and the clinical implications of cardiologist-supervised
(CARD-Sed) versus anesthesiologist-supervised sedation (ANES-Sed) are
unknown. Methods: We reviewed non-operative TEE records from a
single academic center over a five-year time period and identified
CARD-Sed and ANES-Sed cases. We evaluated the impact of patient
comorbidities, cardiac abnormalities on transthoracic echocardiogram
(TTE), and the indication for TEE on sedation practice. We analyzed the
use of CARD-Sed versus ANES-Sed in light of institutional guidelines,
the consistency in the documentation of pre-procedural risk
stratification, and the incidence of cardiopulmonary events including
hypotension, hypoxia and hypercarbia. Results: A total of 914
patients underwent TEE, with 475 (52%) receiving CARD-Sed and 439
(48%) ANES-Sed. The presence of obstructive sleep apnea (p=0.008), a
BMI greater than 45kg/m (p<0.001), an EF
of less than 30% (p<0.001) and pulmonary artery systolic
pressure of more than 40 mm Hg (p=0.015) were all associated with the
use of ANES-Sed. Of the 178 (19.5%) patients with at least one caution
to non-anesthesiologist-supervised sedation by the institutional
screening guideline, 65 (36.5%) underwent CARD-Sed. In the ANES-Sed
group, where intraprocedural vital signs and medications were documented
in all cases, hypotension (n = 91, 20.7%), vasoactive medication use
(n=121, 27.6%), hypoxia (n= 35, 8.0%), and hypercarbia (n= 50, 11.4%)
were noted. Conclusions: This single-center study revealed that
56% of the non-operative TEE utilized ANES-Sed over five years.
Sedation-related hemodynamic changes and respiratory events were not
infrequently encountered during ANES-Sed.
Energy and Carbon Loss Management in an Electric Bus Factory for Energy Sustainability
Authors: Savran Efe , Yavaş Özcan , Erolnalbur Berrak , Karpat Fatih
Published: October 2022

Increasing energy need brings people one step closer to energy saving and alternative sources. The search for reliable and sustainable resources also contributes greatly to technological progress. Thanks to advanced technology, energy use becomes more efficient. However, the concept of sustainability emerges in the field of energy as in other sectors. It is expected that electric vehicles, which have started to increase in interest in recent years, will make a positive contribution to issues such as environmental protection and sustainable energy.  In addition, production centers for electric vehicles should also be sustainable and sensitive to carbon emissions. In this study, energy and carbon loss assessment was carried out in an electric bus manufacturing factory. With the help of linear regression analysis, the data of the last 3 years were evaluated. Moreover, as a result of internal audits, energy loss points were determined. As a result of this study, sustainability, carbon loss, and energy management issues in an electric vehicle production factory were evaluated and guiding qualities for today's and future technology companies were revealed.
The Antipsychotic Dopamine 2 Receptor Antagonist Diphenylbutylpiperidines Improve Glycemia in Experimental Obesity by Inhibiting Succinyl-CoA:3-Ketoacid CoA Transferase
Authors: Tabatabaei Dakhili Seyed Amirhossein , Greenwell Amanda A. , Yang Kunyan , Abou Farraj Rabih , Saed Christina T. , Gopal Keshav , Chan Jordan S.F. , Chahade Jadin J. , Eaton Farah , Lee Crystal , Velázquez-Martínez Carlos A. , Crawford Peter A. , Glover J.N. Mark , Al Batran Rami , Ussher John R.
Published: October 2022

Despite significant progress in understanding the pathogenesis of type 2 diabetes (T2D), the condition remains difficult to manage. Hence, new therapeutic options targeting unique mechanisms of action are required. We have previously observed that elevated skeletal muscle succinyl CoA:3-ketoacid CoA transferase (SCOT) activity, the rate-limiting enzyme of ketone oxidation, contributes to the hyperglycemia characterizing obesity and T2D. Moreover, we identified that the typical antipsychotic agent pimozide is a SCOT inhibitor that can alleviate obesity-induced hyperglycemia. We now extend those observations here, using computer-assisted in silico modeling and in vivo pharmacology studies that highlight SCOT as a noncanonical target shared among the diphenylbutylpiperidine (DPBP) drug class, which includes penfluridol and fluspirilene. All three DPBPs tested (pimozide, penfluridol, and fluspirilene) improved glycemia in obese mice. While the canonical target of the DPBPs is the dopamine 2 receptor, studies in obese mice demonstrated that acute or chronic treatment with a structurally unrelated antipsychotic dopamine 2 receptor antagonist, lurasidone, was devoid of glucose-lowering actions. We further observed that the DPBPs improved glycemia in a SCOT-dependent manner in skeletal muscle, suggesting that this older class of antipsychotic agents may have utility in being repurposed for the treatment of T2D.
Construcción de índices de capacidad para el análisis y evaluación de procesos con múltiples respuestas
Authors: Cuamea Cruz Guillermo , Rodríguez Medina Manuel Arnoldo , Poblano Ojinaga Eduardo Rafael , García Martínez Rafael , Sandoval Chávez Diego Adiel
Published: October 2022

Los productos fabricados actualmente tienen varias características de calidad, todas tienen importancia para el cliente, y controlarlas y evaluarlas se ha convertido en una actividad de primer interés. La industria automotriz establece índices de capacidad para evaluar la capacidad de los procesos donde se tiene únicamente una variable de respuesta, y cuando estos son estables se recomienda utilizar el Cp y el Cpk como medibles de la capacidad del proceso de manufactura para manufacturar productos que cumplan con las especificaciones y sean catalogados como productos de calidad. Para evaluar la calidad completa de un producto, la cual depende de que se cumpla con varias características de calidad simultáneamente, existen propuestas en la literatura de cómo medir la capacidad de procesos multivariados; la mayoría de estas coinciden en que se debe establecer claramente una región de especificación que represente lo que establece el cliente y otra región que muestre la variación como medida de desempeño del proceso. En la definición de ambas regiones existe una gran controversia entre los autores, lo que lleva a presentar esta nueva propuesta, mediante la cual se definen de manera confiable estas dos regiones mencionadas, y al hacer una comparación entre ellas se pueden obtener los índices de capacidad multivariados Cpm y el Cpkm y el como una extensión de los índices univariados Cp y el Cpk. El documento incluye el análisis de datos de un proceso donde el producto, para ser de buena calidad, debe cumplir con dos características de calidad simultáneamente. Las mediciones obtenidas del proceso se pueden representar por una distribución normal multivariada, lo que permite medir la capacidad del proceso utilizando los índices propuestos y realizar una interpretación de estos en relación con el desempeño del proceso.
Integration between BIM and GIS for Decision-Making
Authors: Roumyeh Mohamad Louay , Badenko Vladimir Lvovich
Published: October 2022

Nowadays the integration between building information modeling (BIM) and geographical information systems (GIS) represents one of the important issues because of its benefits during the whole life cycle of the assets. Each of these technologies has great capabilities and using them together can create a significant move in the construction industry. The aim of this research paper is to represent a method to use GIS data and features inside the BIM environment to create a 3D model which will contribute to getting a better understanding during the design phase of the project in order to choose the optimal location. To explain our method, it was decided to choose a location to create a model for the construction of a supposed dam. This will show how GIS and BIM can help in such strategic projects.
Aplikasi Variasi Isolat Bakteri Pada Pupuk Cair Limbah Pasar Ikan Terhadap Pertumbuhan dan Produksi Bawang Merah (Allium ascalonicum L)
Authors: Murdianti Imas , Sujarwanta Agus , Achyani Achyani
Published: October 2022

Abstrak: Produksi bawang merah dapat ditingkatkan melalui perbaikan teknis budidaya, antara lain dengan cara aplikasi variasi isolate bakteri pada pupuk cair limbah pasar ikan. Pupuk cair limbah pasar ikan dengan variasi isolate bakteri tertentu menunjukkan pengaruh terhadap pertumbuhan dan produksi  bawang merah yang lebih baik. Penelitian ini bertujuan mengkaji respon pertumbuhan dan produksi bawang merah terhadap pemberian pupuk organik cair dari limbah pasar ikan dengan variasi isolate bakteri dan mendapatkan variasi isolate bakteri pada pupuk cair limbah pasar ikan terbaik pengaruhnya terhadap pertumbuhan dan produksi bawang merah. Penelitian ini dilakukan selama 8 minggu (56 hari) setelah tanam, dan jenis penelitian ini adalah eksperimen menggunakan Rancangan Acak Lengkap (RAL) dengan 5 perlakuan dan 1 kontrol serta 5 kali ulangan. Parameter yang digunakan meliputi tinggi tanaman, jumlah helai daun, dan jumlah umbi tanaman bawang merah. Data utama ditabulasikan dan dianalisis menggunakan aplikasi SPSS 26.0 dengan uji Analisis Varians (ANOVA) Satu Arah atau One Way Anova. Disimpulkan bahwa aplikasi pupuk cair limbah pasar ikan variasi P4 dengan jumlah 12 isolat bakteri (komposisi 100% limbah cair pasar ikan) memberikan pengaruh paling optimal terhadap pertumbuhan ( tinggi, jumlah helai daun, dan jumlah umbi ) pada tanaman bawang merah (Allium ascalonicum L)

 

Abstrack. The production of shallots can be increased through technical improvements in cultivation, among others by the application of various bacterial isolates in fish market waste liquid fertilizer. Liquid organic fertilizer from fish market waste with a certain variety of bacterial isolates showed a better effect on growth and production of shallots. This study aims to examine the response of growth and production of shallots to the application of liquid organic fertilizer from fish market waste with a variety of bacterial isolates and to obtain variations of bacterial isolates in liquid fertilizer from fish market waste which have the best effect on the growth and production of shallots. This research was conducted for 8 weeks (56 days) after planting, and the type of this research was an experimental study using a completely randomized design (CRD) with 5 treatments and 1 control and 5 replications. Parameters used include plant height, number of leaves, and number of bulbs of shallot plants. The main data were tabulated and analyzed using the SPSS 16.0 application with the One Way ANOVA test. It was concluded that the application of liquid fertilizer from fish market waste variation P4 with a total of 12 bacterial isolates (composition of 100% fish market wastewater) gave the most optimal effect on growth (height, number of leaves, and number of bulbs) on shallot (Allium ascalonicum L) plants.
PENGEMBANGAN LEMBAR KERJA PESERTA DIDIK (LKPD) INKUIRI TERBIMBING BERBASIS E-LEARNING PADA MATERI PLANTAE
Authors: Agustina Evi , Muhfahroyin Muhfahroyin , Sujarwanta Agus
Published: October 2022

Abstrak: Proses pembelajaran tidak terbatas hanya bertempat disekolah, bertemu dan berinteraksi dengan guru secara langsung, pembelajaran bisa dilakukan dimana saja dan kapan saja sesuai dengan kondisi. Adanya virus pandemi covid-19 membuat peserta didik belajar secara mandiri, untuk memfasilitasi peserta didik maka perlu adanya bahan ajar berupa LKPD yang dapat membimbing peserta didik belajar secara mandiri. Tujuan pengembangan LKPD dengan model inkuiri terbimbing berbasis e-learning dapat memberikan inovasi baru dalam proses pembelajaran dengan pemanfaatan teknologi informasi yang semakin canggih. Sehingga meminimalisir masalah yang terjadi dalam proses pembelajaran di masa pandemi.

 

Kata kunci : LKPD, Inkuiri Terbimbing, Schoology

 

 

Abstract: The learning process is not limited to only taking place in schools, meeting and interacting with teachers directly, learning can be done anywhere and anytime according to conditions. The existence of the covid-19 pandemic virus makes students learn independently, to facilitate students, it is necessary to have teaching materials in the form of LKPD that can guide students to learn independently. The purpose of developing LKPD with a guided inquiry model based on e-learning can provide new innovations in the learning process by utilizing increasingly sophisticated information technology. So as to minimize problems that occur in the learning process during the pandemic.

                                                                  

Keywords: LKPD, Guided Inquiry, Schoology
MEDIA ULAR TANGGA TIPE SOAL HOTS ( Higher Order Thinking Skill) UNTUK MENINGKATKAN MOTIVASI BELAJAR PESERTA DIDIK
Authors: Isnawati Beti Aprilia , Muhfahroyin Muhfahroyin , Sujarwanta Agus
Published: October 2022

media is a tool used to convey messages or information. Learning media are developed because of the difficulties often experienced by students in the learning process. Difficulties that are often experienced by students do not understand the material presented so that students' activities are low, students are less active and less motivated to learn, so the learning outcomes of students do not reach the specified KKM value. The purpose of this study is to produce a ladder snake learning media that uses HOTS type questions that are valid and appropriate to be used to overcome problems experienced by students. This type of research uses a 4-D model that has 4 stages, namely, defining the design, development and dissemination. Research carried out until the development stage.
PENGARUH GAYA KEPEMIMPINAN DEMOKRATIS DAN SUPERVISI AKADEMIK KEPALA SEKOLAH TERHADAP KINERJA GURU DI SMA SEPUTIH BANYAK
Authors: Rosida Oknisa Nur , Andayani Sutrisni , Aminin Sudirman
Published: October 2022

Penelitian ini bertujuan untuk menjelaskan pengaruh langsung gaya kepemimpinan demokratis berpengaruh langsung terhadap kinerja guru di SMA Seputih Banyak,untuk menjelaskan pengaruh langsung supervisi akademik berpengaruh langsung terhadap kinerja guru di SMA Seputih Banyak, dan untuk menjelaskan pengaruh langsung gaya kepemimpinan demokratis dan supervisi akademik berpengaruh langsung secara simultan terhadap kinerja guru di SMA Seputih Banyak Seputih Banyak. Jenis penelitian yaitu Ex-Post Facto dengan teknik analisis dalam penelitian ini adalah pengaruh dengan uji regresi sederhana dan regresi ganda. Gaya kepemimpinan demokratis berpengaruh positif terhadap kinerja guru di SMA Seputih Banyak, ditunjukan oleh Sig. = 0,001 < 0,05 yang berarti bahwa ada pengaruh gaya kepemimpinan demokratis terhadap kinerja guru dengan nilai koefisien determinasi sebesar 0,253. Dengan demikian, sumbangan efektif yang diberikan oleh variabel gaya kepemimpinan demokratis terhadap kinerja guru sebesar 25,3%.Ada pengaruh positif supervisi akademik kepala sekolah terhadap kinerja guru di SMA Seputih Banyak, ditunjukan oleh Sig. = 0,027 < 0,05 yang berarti bahwa ada pengaruh supervisi akademik kepala sekolah terhadap kinerja guru dengan nilai koefisien determinasi sebesar 0,116. Dengan demikian, sumbangan efektif yang diberikan oleh variabel supervisi akademik kepala sekolah terhadap kinerja guru sebesar 11,6%. Ada pengaruh positif antara gaya kepemimpinan demokratis dan supervisi akademik kepala sekolah secara bersama-sama terhadap kinerja guru di SMA Seputih Banyak, ditunjukan oleh Sig. = 0,003 < 0,05 yang berarti bahwa ada pengaruh antara gaya kepemimpinan demokratis dan supervisi akademik kepala sekolah secara bersama-sama terhadap kinerja guru dengan sumbangan efektif yang diberikan sebesar 26,3% dipengaruhi oleh variabel lain yang tidak dibahas dalam penelitian. Dari hasil pembahasan tersebut sesuai dengan tujuan penelitian bahwa gaya kepemimpinan demokratis dan supervisi akademik kepala sekolah sangat mempengaruhi kinerja guru khususnya di SMA Seputih Banyak.
PENGARUH BUDAYA KERJA DAN SUPERVISI AKADEMIK TERHADAP PROFESIONALISME GURU SMK
Authors: Rahmawati Rahmawati , Noor Marzuki , AM Sudirman
Published: October 2022

Guru adalah penentu dalam pendidikan. Penerapan kompetensi pedagogik sangat penting karena seorang guru diharapkan mampu dengan materi pembelajaran. Kompetensi guru perlu dievaluasi dan dibimbing, sehingga dapat dilihat dan diukur tingkat keberhasilannya untuk meningkatkan kualitas dan mutu Pendidikan. Penelitian ini bertujuan  (1) Untuk mendeskripsikan kekuatan pengaruh budaya kerja terhadap kompetensi pedagogik, (2) Untuk mendeskripsikan kekuatan pengaruh supervisi akademik terhadap kompetensi pedagogik, dan (3) Untuk mendeskripsikan kekuatan pengaruh budaya kerja dan supervisi akademik secara bersama-sama terhadap kompetensi pedagogik. Populasi 104 dan sampel  51 responden dengan menggunakan rumus Slovin. Pengambilan data menggunakan angket dan regresi menjadi alat penelitian. Hasilnya adalah (1) Terdapat pengaruh positif dan signifikan budaya kerja terhadap kompetensi pedagogik guru SMK se-Kecamatan Seputih Mataram Kabupaten Lampung Tengah, sebesar 62,2% dengan persamaan regresi Ŷ = 23,165 + 0,321X1. (2) Terdapat pengaruh positif dan signifikan supervisi akademik terhadap kompetensi pedagogik guru SMK se- Kecamatan Seputih Mataram Kabupaten Lampung Tengah, sebesar 79,7% dengan persamaan regresi Ŷ = 3,074 + 0,749X2. (3) Terdapat pengaruh positif dan signifikan budaya kerja dan supervisi akademik secara bersama-sama terhadap kompetensi pedagogik guru SMK se-Kecamatan Seputih Mataram Kabupaten Lampung Tengah sebesar 83,3% dengan persamaan regresi Ŷ = 3,584 + 0,115X1 + 0,573X2. Dapat disimpulkan bahwa budaya kerja dan supervisi akademik berpengaruh positif terhadap kompetensi pedagogik. Peneliti menyimpulkan budaya kerja dan supervisi akademik dapat meningkatkan kompetensi pedagogik, sehingga  jika dilaksanakan dengan maksimal maka kompetensi pedagogik akan semakin meningkat.
Laparoscopic appendectomy in a child with hemophilia A with inhibitors receiving prophylactic treatment with emicizumab
Authors: Lavrentyeva I. N. , Vdovin V. V. , Petrov V. Yu. , Mordvin P. A. , Shevchenko T. V. , Kopylov I. Yu. , Tiganova O. A. , Kumirova E. V. , Kozlov M. Yu.
Published: October 2022

Surgeries in patients treated prophylactically with emicizumab (including surgical procedures with a high risk of postoperative bleeding) are not associated with higher risks or technical difficulties compared with operations in patients receiving standard replacement therapy. On the contrary, the presence of emicizumab in the blood and its maintenance of permanent basic hemostasis allow for the reduction of doses and infusion time of bypassing agents. Patients undergoing surgical procedures with a high risk of postoperative bleeding require an additional hemostatic treatment during the first two or three days after the surgery. Then the duration of hemostatic treatment should be determined individually. We recommend the use of recombinant activated factor VII for the prevention/control of postoperative bleeding in patients with hemophilia A with inhibitors who are currently receiving emicizumab or have received it in the past 6 months. If treatment with anti-inhibitor coagulant complex is required, the daily dose should not exceed 100 units/kg. Here we report the first case of laparoscopic appendectomy in an 8-year-old child with hemophilia A with inhibitors receiving prophylactic treatment with emicizumab. The patient's parents gave their consent to the use of their child's data, including photographs, for research purposes and in publications.
The electron microscopy contribution to platelet structural pathology investigation
Authors: Obydennyi S. I. , Kireev I. I. , Panteleev M. A.
Published: October 2022

This article discusses the role of electron microscopy in the diagnosis and study of morphological changes that cause platelet structural abnormalities in a variety of congenital diseases. Morphological abnormalities can be divided into the abnormalities of the platelet cytoskeleton, of alpha and dense granules, and membrane abnormalities. Our paper describes ultrastructural platelet defects in Wiskott–Aldrich syndrome, MYH9-associated syndromes, gray platelet syndrome, Hermansky–Pudlak syndrome, Paris–Trousseau syndrome, Chediak–Higashi syndrome.
Assessment of serum neopterin and kynurenine levels in Egyptian children with sickle cell disease: a single center study
Authors: El-Hawy M. A. , Bedair H. M. , Madkour A.M. Y.M. , Moussa S.M. T. , Mahmoud A. A.
Published: October 2022

Neopterin, a guanosine triphosphate metabolite, is an indicator for cell-mediated immunity. Kynurenine performs a variety of biological functions, such as the dilation of blood vessels in response to inflammation and the regulation of immune response. Objectives: to assess serum neopterin and kynurenine levels in Egyptian children with sickle cell disease (SCD). In our case-control study, we included 40 children aged 2–18 years with SCD treated at the Hematology Unit of the Department of Pediatrics, Menoufia University Hospital and 40 healthy controls matched on age, sex, and socio-economic status. The study was approved by the Institutional Review Board (IRB) of the Menoufia Faculty of Medicine. We obtained comprehensive health history data of the study participants and performed necessary clinical examinations and tests including complete blood count, serum ferritin, and hemoglobin electrophoresis. Serum neopterin and kynurenine concentrations were measured using enzyme-linked immunosorbent assay. In the patients with SCD, serum neopterin and kynurenine levels were significantly higher during vaso-occlusive crisis than in a steady state, and much higher than in the controls (p < 0.001). There was a significant positive correlation between serum neopterin concentrations and mean corpuscular hemoglobin levels, platelets, HbF, HbS, and HbA2, and a significant negative correlation between serum neopterin levels and height, Hb, hematocrit and HbA1. We also observed a significant positive correlation between serum kynurenine and body mass index, HbA2, HbF, HbS, and platelets and a significant negative correlation between serum kynurenine and hemoglobin, hematocrit and HbA1. The cases were shown to have higher neopterin and kynurenine levels than the controls. The concentrations of neopterin and kynurenine were higher in the patients during vaso-occlusive crises than in a steady state.
Customer-Centric Sales Forecasting Model: RFM-ARIMA Approach
Authors: Londhe Sanket Tanaji , Palwe Sushila
Published: October 2022

Background: Decision makers use the process of determining the best course of action by processing, analysing & interpreting the data to gain insights, known as Business Intelligence. Some decision support systems use sales figures to predict future expansion, but few consider the effect of customer data.

Objectives: The main objective of this study is to build a model that will give a forecast based on fine-tuned sales numbers using some customer-centric features.

Methods/Approach: We first use the RFM model to segment the customers into distinct segments based on customer buying characteristics and then discard the segments that are irrelevant to the business. Then we use the ARIMA model to do the sales forecasting for the remainder of the data.

Results: Using this model, we were able to achieve a better fitment of the data for the prediction model and achieved a better accuracy when used after RFM analysis.

Conclusions: We tried to merge two different concepts to do a cross-functional analysis for better decision-making. We were able to present the RFM-ARIMA model as a better metric or approach to fine-tune the sales analysis.
Technological Innovation in Colombian Small Firms: A Gender Multi-Group Analysis
Authors: Cuevas-Vargas Héctor , Velázquez-Espinoza Noé , Colín-Salgado Mónica
Published: October 2022

Background: Studies on innovations have been focused on teams, institutions, and organisations without accounting for the role of the executive’s gender.

Objectives: This research aims to analyse how small Colombian firms manage technological innovation from the perspective of the gender of executives.

Methods/Approach: A quantitative approach and cross-sectional, non-experimental design through Structural Equation Models with PLS-SEM was used. We self-administered a survey randomly to gather data from 145 small firms’ owners or managers in the department of Bogota, Colombia.

Results: The results obtained from multi-group analysis evidence that process innovation has a strong and significant positive impact on the innovation of products, and no significant differences were found when comparing the performance of male executives versus female executives. However, descriptive statistics showed that female executives give more importance to the process and product innovation activities, and they demonstrated to manage a better product innovation performance than male executives.

Conclusions: The evidence reveals that female executives are more committed to developing new products and choose to acquire new skills or equipment to develop products and processes. It is, therefore, essential to eliminate organisations’ cultural stereotypes and take advantage of women’s potential in management leadership.
Employers’ Revelation of Decision-making Keys for Employing People with Visual Impairment: Mixed-method Analysis of Employers’ Motivations
Authors: Eckhaus Eyal
Published: October 2022

Background: People with visual impairment or blindness (PWVIB) face many barriers related to employment. Although literature explores employers’ concerns regarding the employment of PWVIB, stating the concern and developing a solution are different.

Objectives: Employers’ solutions to concerns regarding hiring PWVIB have not been surveyed. This study addresses the gap by surveying employers to determine practical solutions and developing the Solutions for Improving Employment of People with Visual Disabilities (SIEPVD) model.

Methods: We employed a mixed-method design based on the 975 completed surveys from employers with hiring authority. We also identified and tagged major themes and developed an empirical model. Structural Equation Modelling (SEM) was employed to test the model’s goodness of fit.

Results: Findings highlight the need for evidence of job capabilities such as financial incentives, information provision, and adequate job vacancies. Evidence or financial incentives directly and positively affect employers’ attitudes toward hiring PWVIB. Financial incentives also mediate information provision and job match with employers’ attitudes toward hiring PWVIB.

Conclusions: This is the first study to perform employers’ integration by creating solutions to increase PWVIB’s employment rate. Results may help PWVIB in its employment efforts. Thus, the approach when applying for jobs or attending interviews should be reviewed. Practical contributions are discussed.
Public Support for Innovation: Changes in Turnover of Granted Companies
Authors: Klímová Viktorie , Žítek Vladimír , Lelková Tereza
Published: October 2022

Background: Innovation policy supports innovation in companies, as it is crucial for economic, social and environmental development.

Objectives: The research aims to verify whether companies that have received public support for innovation are experiencing turnover growth.

Methods/Approach: The research is carried out on the example of the Czech Innovation Programme, and the analysis included 276 projects in the manufacturing industry. The study compares the turnover of enterprises one year before receiving the aid and two years after the granting. The analysis is performed regarding the size of companies, industries and regions.

Results: When the companies are assessed at the median level, the largest turnover growth was found in the category of small enterprises. Regarding industry, the largest increase was recorded in NACE sections 22, 27, 26, 29 and 30. The lowest increase in turnover was recorded for enterprises in sections 21, 23, 24 and 28. Differences in turnover growth were also observed across regions.

Conclusions: Providing support for innovation contributes to the growth of turnover. A larger share of public aid should be allocated to the category of small and medium-sized enterprises and knowledge-intensive industries.
Applying Model of Brand Equity in Higher Education Marketing Context
Authors: Vukasović Tina
Published: October 2022

Background: The idea of brands is currently swiftly transferring from the market for goods to the market for services, giving rise to the service brand. Globalisation, the accelerated and increased development of service activities, and more rivalry in the provider’s market have all contributed to this.

Objectives: The primary goal of this study is to empirically test the conceptual model in higher education to create a comparative study based on different contextual dimensions and better understand brand equity in higher education.

Methods/Approach: A quantitative research method was applied. Using a questionnaire, which was sent to students by e-mail, the data were collected. The sample chosen targeted 250 actual (university students) in Slovenia.

Results: Consumer traits and concepts related to the brand equity’s awareness dimension have no discernible influence on consumers’ perceptions of brand equity. Promotional actions intended to increase brand equity by increasing awareness were ineffective and had a favourable effect on the brand equity of the symbolic qualities. All service characteristics were discovered to be important. Price, excellent quality, and benefits all had a large and positive impact on brand equity. In conclusion, all financial factors had a substantial and favourable effect on brand equity.

Conclusions: The research’s findings showed that the customer-based brand equity model might be used to create a competitive advantage in the higher education sector and to direct marketing efforts.
European Union’s New Pact on Migration and Asylum: Enhancing the Legal Protection of Refugees and Asylum Seekers or Restoring the Old Paradigm?
Authors: Čanji Danijela
Published: October 2022

In this article, I seek to examine how the legal and political changes introduced by the European Union’s New Pact on Migration and Asylum enhance the legal protection of refugees and asylum seekers fleeing to the EU territory across the central Mediterranean migration route. Empirically drawing on the discourse of the European Commission representatives and the discourse around the new Pact on Migration and Asylum, I will engage in analyzing the EU’s human-focused narrative about migration management that the Pact promotes. The emphasis is put on how the dominant legal categories, in particular the category of refugee, are (re)constructed and the purposes such re-articulation has for the rights of the people on the move. Situating the study into critical legal theoretical framework, my aim is to demonstrate that although the EU’s new narrative acknowledges migrants’ vulnerable position, persons in need of international protection are simultaneously put into the discursive frame of irregularity – the same discourse the EU is vehemently fighting against. Hence, due to the conceptual ambivalence of the legal identities, under the new Pact, the persons legally entitled to protection will find it more difficult to claim their right to safe asylum in the EU.
Streisand Effect in the Context of the Right to be Forgotten
Authors: Mach Martin
Published: October 2022

This article discusses the Streisand effect in Right to be forgotten. Since this is a highly undesirable phenomenon, the article seeks to answer questions that reveal its frequency and the chance of its manifestation, thus answering the questions of how common the Streisand effect in right to be forgotten is; and it seeks and analyzes the variables that affect the chance of the Streisand effect. To find answers, the article draws on court decisions and also uses the insights of authors working on similar topics. Thus, each variable is justified and shown in a specific real case. The article concludes with a look at the possible increase in the Streisand effect in the future.
The Shifting Approach of the Court of Justice of the European Union towards the Principle of Mutual Trust and the Impact of the Rule of Law
Authors: Ozoráková Lilla
Published: October 2022

The principle of mutual trust is based on the idea that there is mutual confidence between Member States that their national legal systems are in line with the European Union law and are able to provide similar protection of the shared values. However, the experience of last years has brought multiple challenges questioning these fundamental building blocs. This article focuses on understanding the role of fundamental rights and the rule of law in limiting the principle of mutual trust as suggested by the case law of the Court of Justice of the European Union (CJEU). It discusses the shift in the approach of the CJEU towards the limitations, exploring whether the recent case law suggests that the current crises of values, including the systemic violations of the rule of law and fundamental rights play a crucial role in widening the limits of mutual trust.
Euro-Conform Interpretation of Slovak Consumer Credit Act – Endless Saga Bound to End?
Authors: Patakyová Mária T.
Published: October 2022

Protection of individual rights arising from EU law is to a great extent in the hands of national courts. Their role is underlined in cases of imperfect implementation of a directive, where individuals are left at mercy of a euro-conform interpretation. Euro-conform interpretation is not limitless, as, for instance, it shall not be contra legem. However, when exactly is the interpretation contra legem, i.e. impossible? This article shows how intricate euro-conform interpretation may be, using the example of Directive 2008/48/EC on consumer credit agreements, a piece of law much discussed by the ECJ in preliminary rulings. Even if the proper way of interpretation is shown by the Supreme Court of a Member State, individuals may still find it difficult, even impossible, to enforce their rights arising from EU law. The aim of this article is to show how the euro-conform interpretation works in practice.