bluuebunny/crossref_metadata_2025 huggingface dataset:
Agricultura de precisão: ferramenta de gestão na rentabilidade e produtividade de grãos
Authors: Borges Lino Carlos , Nascimento Abadia dos Reis , Morgado Cristiane Maria Ascari
Published: February 2022

A agricultura de precisão é um processo gerencial. São várias as ferramentas utilizadas dentro da agricultura de precisão, tais como: eletrônica embarcada, geoestatística, sensores, etc, sendo que a tecnologia de informação é usada no manejo da propriedade e leva em consideração a variabilidade espacial e temporal que podem interferir na produtividade e rentabilidade. Nesse contexto, o objetivo deste trabalho foi realizar um levantamento bibliográfico, apresentando os conceitos de agricultura de precisão, seu foco na rentabilidade, bem como sua utilização na produção de grãos. Trata-se uma revisão bibliográfica simples em que foram pesquisados artigos científicos a respeito da agricultura de precisão e sua utilização com foco na rentabilidade e produção de grãos. Para tanto, as plataformas de pesquisa utilizadas foram o Google Acadêmico, o Scielo e a Elsevier, por meio das palavras-chave: agricultura de precisão, rentabilidade e produção de grãos. A agricultura de precisão na produção de grãos é uma ferramenta que auxilia o produtor na tomada de decisões, além de proporcionar economia, devido à redução da utilização de insumos e menor impacto no meio ambiente, se tornando, dessa forma, essencial para que informações sejam obtidas com o intuito de melhor entender e gerenciar os sistemas de produção agrícola. Além disso, a busca por mais informações e inovações por parte do agricultor brasileiro que o auxiliem na sua rotina de trabalho e aumentem sua rentabilidade faz com que a agricultura de precisão seja cada vez mais empregada, já que essa busca por inovações será essencial para destacar o Brasil quanto ao abastecimento mundial de alimentos nos próximos anos.
Black Lawyers Matter: Enduring Racism in American Law Firms
Authors: Dias Vitor
Published: February 2022

Scholars and practitioners have extensively examined patterns of racial inequality in U.S. corporate law firms. In the corporate bar, pull factors that have long shaped legal professionals’ careers include promotions, outside job offers, and family priorities that may lead to leaving the labor force altogether. Push factors, such as discrimination, problems with management, and work-life conflict, also precipitate work transitions. Beyond corporate firms, however, an urgent question remains open to empirical scrutiny: How does race affect career moves in the contemporary American legal profession?

In this Article, I address this question drawing upon data from the first nationally representative, longitudinal survey of U.S. lawyers. This study is one of few that uses event history analysis as a statistical technique to examine legal careers. It also draws on in-depth interviews to unravel how lawyers view their experiences at firms. These legal professionals detail how race influences assignment distribution and promotion within American law firms. Assessment of work histories of over 4,000 law school graduates, from the time they were admitted to practice in the year 2000, shows that, all else being equal, Black lawyers are pushed out of private law firms at much higher rates than white lawyers. As Black lawyers continue to strive for racial equality, these results indicate that race-conscious remedies remain critical not only for the future of law firms, but also for the broader legal profession.
Blue Racing: The Racialization of Police in Hate Crime Statutes
Authors: Williams Christopher
Published: February 2022

Content warning: this Article discusses police brutality.

The relationship between race, law, and policing is one that has been analyzed by many scholars throughout U.S. history. The vast majority of research about police has highlighted policing in relation to groups they police, focusing on areas such as policing practices, policies, or involvement in the racialization of minority groups. This scholarship has far outpaced research on actions taken by law enforcement on behalf of law enforcement— specifically, how law enforcement engages in racialization out of self-interest. A better understanding of the ways in which law enforcement engages in racialization that is not just limited to other groups would provide a new way for understanding race, law, and policing. In addition, such an understanding would provide the appropriate context for policies and laws birthed out of the police racialization process.

In this Article, I explore the racialization process of police by police (“blue racing”) in the context of hate crime legislation. I argue that the passage of hate crime legislation that included law enforcement, which I will refer to as “blue lives matter bills,” was not the result of increased violence or threats to officer safety, despite the rationale offered by the bills’ proponents. Instead, utilizing both Zakiya Luna’s “racial framing” and Michael Omi and Howard Winant’s “racial project” concepts, I argue that including law enforcement as a protected category within hate crime statutes was part of a racial project, engaged in by the countermovement blue lives matter, to prevent and criminalize protests that called attention to law enforcement abuse. Essential to this racial project was the blue racing of police. In this way, blue lives matter bill proponents used racial framing to legitimize their claims of alleged oppression. This legitimization gave both the blue lives matter bill proponents and legislatures the cover to punish and reprimand protestors of law enforcement brutality.
2020 Bali's Coral Conservation: from pandemic challenge to Government coral garden project
Authors: Wicaksana Ida Bagus Agung
Published: February 2022

Bali's coral reef restoration has been the topmost priority by the Indonesian Government and marine activists to save marine habitat in the long run. The action is necessary to halt severe damage that occurs in aquatic habitat over the years. The most apparent threat that has been faced is coral bleaching. Bali's water's tourism activities have sharply dipped between early to mid-2020, yet it did not stop the coral bleaching phenomenon. The phenomenon is occurring due to water temperature rise. The Government's decision to restrict public activity made the conservation task impossible to be done. Albeit challenges in coral conservation became a daunting task in 2020, pleasant news also came from the central Government. Coordinating Minister for Maritime Affairs and Investment Luhut Binsar Pandjaitan revealed the central Government had compiled a National Economic Recovery (PEN) program for Indonesia Coral Reef Garden (ICRG) Bali. The program is coral reef restoration activities centered in Nusa Dua and several other areas such as Sanur, Serangan, Pandawa Beach, and Buleleng. The coral reef garden will be built using the Ministry of Marine Affairs and Fisheries National Economic Recovery fund worth IDR 111.2 billion. The fund will be used to build a 50 hectares coral plantation. Meanwhile, the Governor of Bali, I Wayan Koster, expressed his appreciation toward the program. Koster believed the program would significantly impact the community, especially in supporting economic recovery since the national economic recovery activities will involve more than 11,000 workers.
ПЕРСПЕКТИВЫ ЛЕЧЕНИЯ И ПРОГНОЗИРОВАНИЯ ТЕЧЕНИЯ ИЗКОДИФФЕРЕНЦИРОВАННЫХ ГЛИАЛЬНЫХ ОПУХОЛЕЙ ГОЛОВНОГО МОЗГА
Authors: Арсаханова Г.А.
Published: February 2022

Злокачественные глиомы составляют 38% в структуре первичных опухолей головного мозга, их частота имеет тенденцию к увеличению в последние 30 лет. Продолжительность жизни пациентов после удаления глиобластомы с адъювантной лучевой терапией и химиотерапией составляет в среднем 14,6 мес. Стандартом лечения злокачественных глиом является максимально безопасная резекция опухоли. В последние годы наблюдают значительный прогресс в понимании механизмов патогенеза злокачественных глиом, что открывает новые возможности для совершенствования лечения. Целью статьи является анализ современных достижений по лечению пациентов по поводу низкодифференцированных глиом головного мозга и определение перспективных направлений дальнейших исследований.
ТЕОРЕТИЧЕСКИЕ ОСНОВЫ СОТВОРЧЕСКИХ ТЕХНОЛОГИЙ В ФОРМИРОВАНИИ ПРОФЕССИОНАЛЬНОГО ИМИДЖА ПЕДАГОГОВ ШКОЛЫ
Authors: Булуева Ш.И. , Ажиев М.В.
Published: February 2022

В статье рассматриваются теоретические основы сотворческих технологий в формировании профессионального имиджа педагогов школы. От профессиональной, качественной подготовки работников образовательной организации зависит будущее российского образования, именно своим примером современный преподаватель формирует новый стиль поведения учащихся. Терминологическое поле проблемы охватывает такие понятия, как «имидж», «школа», «педагог школы», «имидж педагогов школы», которые сейчас активно изучаются отечественными и зарубежными учеными с позиций психологии, социологии, педагогики, философии, экономики, маркетинга, что объясняется сложностью феномена. Авторами рассмотрены основные составляющие имиджа: педагогическое мастерство; уровень профессиональной подготовки; авторитет работников образовательной организации; педагогическая культура; визуальная привлекательность; вербальное и невербальное поведение; манеры и этикет; позициюя общества и государства. А также профессиональные качества личности педагога: широкая эрудиция и свободное изложение материала, умение учитывать психологические и возрастные особенности аудитории, владение темпом речи, а также общую и специальную грамотность, обращение по имени, на «Вы», умение четко формировать конкретные цели, а также умение контролировать степень усвоения учебного материала. Рассмотрен такой термин, как «сотворчество». Совместная деятельность как коворкинг, сотрудничество, дифференциация сотворчества и сотрудничества. Сотворческие технологии не только играют большую роль в образовательной деятельности, но и оказывают большое воздействие на формирование и укрепление имиджа педагогов школы.
ПРОБЛЕМА ФОРМИРОВАНИЯ НРАВСТВЕННЫХ ЧУВСТВ У ШКОЛЬНИКОВ В ПСИХОЛОГО-ПЕДАГОГИЧЕСКОЙ И МЕТОДИЧЕСКОЙ ЛИТЕРАТУРЕ
Authors: Закраилова Б.Р. , Алиева Р.Р.
Published: February 2022

В исследовании изучена проблема формирования нравственных чувств у школьников в психолого-педагогической и методической литературе. Формирование нравственных представлений младших школьников осуществляется в процессе нравственного развития, который организуется направленным нравственным воспитанием. Выявлена проблема, которая состоит в том, что формированию нравственных чувств уделяется недостаточное внимание в воспитании, социализации личности ребенка в связи с технологизацией процесса воспитания; конкретизировано понятие «нравственные чувства школьников», которые мы рассматривали как часть нравственных представлений ребенка, чувства, связанные отношением к себе и окружающему миру, сущность которого состоит в умении ребенка регулировать ожидания от взрослых, сверстников, определенного вида поведения; рассмотрены подходы к формированию нравственных чувств у старших дошкольников - системный, деятельностный, средовый, личностно-ориентированный, при ведущей роли интегративного подхода.
ДОХОДНОСТЬ ОБЛИГАЦИЙ ФЕДЕРАЛЬНОГО ЗАЙМА ДЛЯ ФИЗИЧЕСКИХ ЛИЦ: ВИДЫ И ПОДХОДЫ К РАСЧЕТУ
Authors: Демильханова Б.А.
Published: February 2022

В статье систематизированы отличительные особенности долгового инструмента российского рынка ценных бумаг – облигаций федерального займа для физических лиц, рассматриваемого в качестве финансового инструмента, находящегося между банковским депозитом, и обращающимися на организованном рынке государственными ценными бумагами, обеспечивающего возможность преумножения средств частного инвестора. Осуществлено сравнение облигаций с облигациями для физических лиц, выпускаемыми крупными банками, а также банковским депозитом.
Исходя из того, что недостаточно широко освещены вопросы формирования уровней доходности инвестиций в облигации для населения, вытекающие из условий их эмиссии и обращения, на основе параметров обращения облигаций федерального займа для физических лиц определены различные показатели доходности по отдельным выпускам и выявлены особенности их формирования. Установлено, что определение уровня различных видов доходности облигаций как до осуществления инвестиций, так и после, учитывая налогообложение доходов по ним, способствует достижению максимального эффекта от среднесрочных вложений с использованием возможностей специальных брокерских счетов.
СТАЛИНГРАД: НАЧАЛО
Authors: Бадаева Л.А.
Published: February 2022

В данной статье автор стремится показать соотношение сил Красной Армии и немецкой Германии накануне Сталинградской битвы. Она дает последовательный анализ состояния численности войск и техники с обеих сторон, говорит о перегруппировках в Красной Армии и причинах, заставивших командование сделать такие перестановки. Автор не может не упомянуть мудрость и дальновидность командиров, а также мужество рядовых солдат, взявших на себя удары немецких войск накануне основного сражения.
ETHICAL LEADERSHIP AT WORK AND WORKPLACE WELL-BEING OF EMPLOYEES IN A COAL POWER PLANT
Authors: Diosdado A. Ugmares  , Victoria O. Ligan  , Alberto N. Bandiola
Published: February 2022

This study proposed that ethical leadership at work and workplace well-being are significantly related and that ethical leadership could also significantly influence workplace well-being. There was a total of 122 samples in this study, which included the rank and file workers and employees in a coal power plant, with the exclusion of the top management. The data were analyzed using descriptive and inferential statistics such as the mean and standard deviation, Pearson r, and multiple regression analysis. Results yielded high levels of ethical leadership at work and workplace well-being. Also, the correlation test revealed a significant relationship between the two variables in this study. In addition, the regression analysis revealed a significant influence of ethical leadership on workplace well-being. Finally, the regression models revealed that people-orientation is the best predictor for workplace well-being. The paper offers further discussion of the results.
KEYWORDS: ethical leadership at work, workplace well-being, coal power plant, public administration,Philippines
TRUST EFFECT ON SINO-MONGOLIAN IJV PERFORMANCE
Authors: Enkhzaya Tengis
Published: February 2022

For the last few years, the number of international joint ventures has been increasing and IJV success factors draw scholars’ attention. In many different cultures, especially in IJV, many scholars agreed that trust is an important factor in successful IJV. Most of international investments in Mongolia are from Chinese organizations. The purpose of this paper is to examine level of trust and its’ impact on organization’s performance in Sino-Mongolian IJV. Results show that trust does have impact on performance and Mongolian employees have lower level of trust compared to Chinese employees. Also results show that, people with experience in abroad have higher level of trust and performance satisfaction. Moreover, employees had higher level of trust, but managers had higher level of satisfaction in IJV performance. The findings of this paper will help future researchers and investors, and have provide implications and limitations for further research.
KEYWORDS: Trust, IJV, Performance, Sino-Mongolian, Effect;
ECONOMIC MECHANISM FOR MONITORING THE EFFICIENCY OF SATELLITE SERVICES WHILE THEIR DEVELOPING
Authors:   Peoples’ Friendship University of Russia (PFUR), Russia Moscow, Yudin Alexander V. , Teslenko Irina B. ,   Institute of Economics and Management, Vladimir State University A. G. and N. G. Stoletovs, Russia, Vladimir
Published: February 2022

The article develops the economic mechanism for monitoring the economic efficiency of satellite services in the process of their developing. Using this mechanism, it becomes possible to adjust the economic indicators of competitiveness and find a balance between the price of the service and the volume of sales. This allows the developer (operator) of the service to create a commercialization strategy in the short, medium and long term. The algorithm for regulating the economic parameters of satellite services is proposed based on a mechanism. In practice it allows implementing a sequence of actions for selecting parameters that ensure high competitiveness.
Convection heat transfer analysis in rats and mice
Authors:   Departamento de Engenharia Mecânica, Universidade Federal do Rio Grande do Norte, CEP, Bezerra A. M. M. , Tapia G. I. M. , Cavalcanti M. A. V. , Marinho G. S.
Published: February 2022

Heat transfer is a vitally important mechanism in thermal control of living beings. It is no different for rats and mice, which are widely used for academic, pharmaceutical and medicinal research. The objective of the present study was to estimate the convective heat transfer in rats and mice confined in a vivarium at the UFRN’s Institute of Tropical Medicine. Twenty rats and twelve mice were used for the experiment, where the following measurements were made: surface skin temperature, body length, and weight. The study was able to determine mathematically an approximation of the natural and forced convection heat transfer rates produced by rats and mice, comparing them under the condition of 22°C in a controlled vivarium environment.
The Industrialization of Czechoslovakia, Its Pros and Cons
Authors: Mareš Jaroslav
Published: February 2022

The paper deals with the changes in the distribution of Czechoslovak industry since the end of the 18th century up to the present time. It studies the reasons of industrialization of individual areas, the influence on the distribution of population and urbanization processes. It evaluates not only the achievements of a long-term industrialization but also its negative consequences which we have not been able to get rid of so far.
Guidelines for Nanopharmaceutical Products for Regulatory Approval
Authors: Medhi Bikash
Published: February 2022

The word 'nano' refers to a Greek prefix that means  'dwarf' or very little,' and represents a thousand  millionth of a meter (10-9) in length. Nanoscience and  nanotechnology are the study and application of  nanoscale range materials. Initially, the term  Nanotechnology was used by N. Taniguchi in 1974 at an  international conference on industrial production in  Tokyo to characterize the super-thin processing of  materials with nanometre accuracy and the fabrication of  nano-sized systems (Bayda S. et al., 2020). The usage of  nanomaterials has enhanced the application of  nanomedicine in various therapeutics area with  challenges and limitations over the last ten years.  Alteration of the physiochemical, biological, mechanical  & other properties of the materials made the  nanomaterials and it can be utilized in different useful  activities such as drug development, drug target.  Nanotechnology utilized novel nanomaterials to make  useful products. This technology has been used to  overcome the limitations & challenges in different drug  therapies. (Harea JI et al., 2017).  

 The combination of nanotechnology with  pharmaceuticals and biomedicals is termed nano  pharmaceutical. Nanopharmaceuticals is a new  technology in current practice. As a result, there are no  widely agreed nanopharmaceuticals guidelines. The  general idea of regulatory requirements for Active  Pharmaceutical Ingredients (API), as stated in the  CDSCO's New Drugs and Clinical Trial Rules 2019, was  mandatory in drug development pathways. These criteria  are also in line with the International Council for  Harmonization (ICH) recommendations and  international standards that other countries using such  items follow. New Drugs and Clinical Trials Rules, 2019  should be followed in different drug development. (Harea  JI et al., 2017).  

 Globally, there are important guidelines developed by  the United States Food & Drugs Administration  (USFDA), International Council for Harmonization  (ICH), or Organization for Economic Co-operation and  Development (OECD). (Harea JI et al., 2017).  

 Current regulatory approaches by US Food & Drug  Administration (FDA), established the nanotechnology  task force in August 2006. This regulatory approach  encourages the development of nanoproducts. FDA has  issued the guidelines in 2007 to the industry to address  the benefits & risks of Drugs, medical devices, and other  nanoproducts. FDA is also working with other U.S.  government agencies to focus on the safety & efficacy of  nanoproducts and U.S. initiates the National  Nanotechnology Initiative (NNI) which is a federal  research & development program to coordinate the effort  of all government agencies involved in nanotechnology.  The main goal of the NNI is to maintain the class of  research & development program, encourage inducing  the new technologies in the product, developing the supporting infrastructure & tools needed for  nanotechnology (Ventola et al., 2012).
Green Synthesis and Evaluation of Zinc Oxide Nanoparticles from Manilkara Zapota Leaf Extract
Authors: Maseera Rahath , Sultana Ayesha , K Venu Madhav , M. Kiranmai
Published: February 2022

Background: Zinc oxide Nanoparticles can be prepared by various chemical, physical,  and biological methodologies. But biological approach is easier than the other  methods and also eco-friendly.

Purpose of study: Plant-mediated amalgamation of  Zinc oxide nanoparticles is promising contrast to traditional method of physical and  chemical synthesis.

Method: In the current research work, Zinc oxide nanoparticles  are synthesized by using Leaf extracts of Manilkara Zapota plant. Green synthesis  was done utilizing the aqueous solution of Manilkara Zapota leaf extract as reducing  agent and Zinc acetate salts along with Sodium hydroxide. Morphological, Structural  and Antimicrobial properties of synthesized Zinc oxide nanoparticles were  characterized using Scanning electron microscope, Fourier transform infrared  analysis, Differential scanning calorimetry and Disc diffusion method. '

Results:  Biologically synthesized nanoparticles of Manilkara Zapota leaf extract revealed  significant Anti-bacterial and Anti-fungal activities.

Cocnclusion: The organically  incorporated nanoparticles by Manilkara Zapota can be utilized as antimicrobial  agent against various pathogenic organisms.
Potential Galactogogues: A Review
Authors: Sahu Umakant , Shah Kamal , Chauhan Nagendra Singh
Published: February 2022

Worldwide many infants die every year due to malnutrition or disease. WHO advises  breastfeeding as it is an inexpensive and effective form of feeding for saving life of  infant’s health. Insufficient milk production in lactating mother is one of the main  causes of death and malnutrition in infants. Main cause of milk deficiency is mother  or child illness, preterm birth, mother-baby separation, lactation after long gape,  anxiety, fatigue emotional stress, busy schedules, unhealthy life style of women’s  and hormonal imbalance. This review aims to summarize that insufficiency of  lactation should be treated in appropriate manner; there are substantial numbers of  herbal drugs which are used to augment milk production in lactating mother.  Alcoholic/Aqueous extract of different lactogenic drugs maintain or increase the  lactation by different physiological changes in biological level. The systematic search  for Herbal Medicine used as lactation considering all the articles published until  2021 through three scientific databases.
Impact Artificial Intelligence in the Pharmaceutical Industry on Working Culture: A Review
Authors: Lodhi Devendra Singh , Verma Megha , Golani Pradeep , Pawar Akash Singh , Nagdev Sanjay
Published: February 2022

The pharmaceutical and healthcare industries have benefited greatly from artificial  intelligence in recent years. A wide range of pharmaceutical fields, such as this novel  approach, showed potential in drug discovery, continuous manufacturing (CM),  dosage form design, and quality control. This article focuses on the use of artificial  intelligence in the pharmaceutical sector. Before all else, the film sheds light on how  AI will be implemented into health care, as well as its potential benefits. To  conclude, there are several hurdles to overcome in the project implementation. At  present, it's no secret that artificial intelligence (AI) and genetic algorithms (ANNs)  are becoming increasingly popular in the pharmaceutical industry. In the  pharmaceutical industry, artificial intelligence (AI) has shown promise, and it can be  used in combination with robotics. Physical robots could revolutionize the  healthcare industry. To keep their minds sharp and alert, it's used as a social  interaction guide with elderly patients. In the pharmaceutical industry, artificial  intelligence (AI) will help reduce costs and time.
Parent's Position In Developing Children's Nature Implications In ERA 4.0
Authors: Agus Yosep Abduloh  , Ahmad Nurwadjah  , 3Andewi Suhartini  , Hisam Ahyani  , Naeli Mutmainah
Published: February 2022

The impact of changing times is so great, such as the 4.0 era as it is today for children, teenagers, and parents, who need to adapt to the current era. And it would be nice for us to provide an overview and understanding to our children in a way that is appropriate for their age in order to be able to grasp what we mean. And we should educate more with tenderness and love, the position of parents in developing children's nature, the implications of which in the 4.0 era are very important because with that we can be closer and easier in providing education. The educational method that we use may be done in realizing a disciplined and independent child's personality which stems from the child's desire to achieve happiness in the world and the hereafter. This research method is library research with the object of the verses of the Qur'an using several interpretations from the commentators including: Tafsir Jalalain Tafsir Ibn Kathir Tafsir Al-Maraghi to uncover and explore the Position of Parents in the Al-Qur'an, Role Parents in Developing Children's Fitrah, and Implications of the Role of Parents in Developing Children's Fitrah in the 4.0 era. The results of the study show that 1) The view of Islamic education regarding the nature of the child means that the position of the child has two opposing sides. One side of the child is the trust of Allah entrusted to the parents. On the other hand, children are nature for the lives of parents in particular and society and the environment in general. 2) The implications of the position of parents in developing children's nature, the implications of which in the 4.0 era are a necessity, as mufassir views and opinions Salaf scholars have different opinions in interpreting the word fitrah, the majority argue that the meaning of fitrah is Islam. So that it has become a joint obligation for parents to maintain the mandate of Allah SWT in the form of children, which in the 4.0 era children must be monitored and supervised to ensure that the child's behavior (behavior) as a child who was born naturally (good) in origin.
PEMBELAJARAN PENDIDIKAN JASMANI, OLAHRAGA DAN KESEHATAN SELAMA PANDEMI COVID 19
Authors: Tumaloto Ella H.
Published: February 2022

Penyebaran Covid-19 yang menyebar begitu cepat di Indonesia menyebabkan gangguan pada sektor pendidikan di Indonesia, sehingga mengharuskan siswa tidak dapat melanjutkan kegiatan belajar sebagaimana mestinya di sekolah. Pemerintah pun menyarankan pembelajaran tetap dilaksanakan akan tetapi melalui media Daring (Dalam Jaringan). Penelitian ini bertujuan untuk mengetahui proses pembelajaran PJOK ditengah pandemi Covid-19 SMA Negeri di Kota Kotamobagu, mengetahui keefektifan metode pembelajaran yang diterapkan dalam proses pembelajaran PJOK ditengah pandemi Covid-19 SMA di Kota Kotamobagu, dan mengetahui peran guru PJOK dalam meningkatkan minat belajar siswa ditengah pandemi Covid-19. Metode yang digunakan adalah penelitian kualitatif. Hasil dari penelitian ini adalah pembelajaran PJOK (Pendidikan Jasmani, Olahraga, dan Kesehatan) tetap dilaksanakan di setiap sekolah SMA Negeri Se-Kota Kotamobagu dengan menggunakan metode Daring (Dalam Jaringan), metode Luring (Luar Jaringan) dan tatap muka terbatas. Pada metode daring guru mengakses jaringan internet dibantu oleh aplikasi google meeting, google classroom, what’sApp grup dan portaldik. Pembelajaran Luring (Luar jaringan) guru mendatanagi kelompok peserta didik sesuai dengan zona donasi tempat tinggal peserta didik, sedangkan tatap muka terbatas peserta didik berkunjung ke sekolah dengan jadwal dan waktu yang sudah ditentukan oleh sekolah.
Liver venous deprivation for resection of advanced hilar cholangiocarcinoma—a case report and review of the literature
Authors: Stoyanova Radoslava , Kopf Helmut , Schima Wolfgang , Matzek Wolfgang Karl , Klaus Alexander
Published: February 2022

Hilar cholangiocarcinoma is a rare primary malignancy associated with a dismal prognosis. Currently, complete extended right or left-sided hepatectomy is the primary curative therapy. Achieving a negative resection margin is associated with long-term survival and better quality of life, while post-hepatectomy liver failure (PHLF) due to insufficient liver remnant remains the most dreaded complication with a negative effect on overall survival. Precise preoperative management with sufficient future remnant liver (FRL) volume is the key to achieving good results in the treatment of bile duct carcinoma. To present a case report and a literature review for preoperative FRL optimization prior to major hepatectomies for hilar cholangiocarcinoma. Improvement of postoperative outcomes after extended liver resections in the case of hilar cholangiocarcinoma. A 62-year-old Caucasian woman with Lynch syndrome presented to our department with a hilar cholangiocarcinoma Bismuth type IIIa. The patient had an insufficient future liver volume for extended liver resection. She underwent preoperative preconditioning using a liver venous deprivation (LVD) and underwent two weeks later a right trisectorectomy without any interventional complications. Liver function remained stable postoperatively. The patient was discharged on the 20th postoperative day without major surgical post-operative complications or the need for readmission. LVD is a technically feasible, safe, and effective procedure to increase the FRL in a short period of time with low intra and post-operative complications and therefore improving the survival of patients with hilar cholangiocarcinoma.
Cancer of the oral mucosa (cancer of the tongue, floor of mouth, lower jaw, cheek)/lip: modern therapeutic technologies
Authors: Solodkii Vladimir , Panshin Georgii , Petrovskii Vladimir , Izmailov Timur , Titova Вера
Published: February 2022

Purpose.  Evaluation of the effectiveness of three treatment options for cancer oral mucosa (cancer of the tongue and floor of mouth, cheek, lower jaw)/lip (OC/lip).
Materials and methods. Treated 100 patients with OC/lip: combined treatment with surgery at the first stage and postoperative conformal external beam radiation therapy (EBRT) of 50 Gy — 40 patients; combined conformal EBRT and brachytherapy (BT HDR) — 40 patients; EBRT and photodynamic therapy (PDT) with intensive laser hyperthermia — 20 patients. The age of the patients ranged from 26 to 90 years; among them were 55 men and 45 women.
Results. Five-year overall survival (OS) and relapse-free survival (RFS) in patients with tumors of various localization was 88% and 73.3% respectively with a good quality of life. Five-year OS was for combined method of treatment — 82,8%; combined EBRT and brachytherapy — 94,4% and EBRT in combination with PDT and laser hyperthermia — 83,3% (р=0,561). With tumors of stage I–II, the five-year OS was 94.4% and III–IV stage — decreased to 73.1% with a high level of statistical significance of the χ²=6.042, p=0.014.
Conclusions. OC and lip cancer is most effectively cured in the I–II stage of the disease with the initial implementation of the surgical stage preceding EBRT. EBRT with photodynamic therapy and laser hyperthermia is effective for contraindications for patients to brachytherapy. The determination of PM (predictive markers) is a promising direction in optimizing the antitumor treatment of malignant neoplasms of OC/lip.
Levels of steroid hormones, their receptors, prolactin and SSBG in tissues of patients with gastric cancer
Authors: Kit Oleg , Frantsiyants Elena , Kaplieva Irina , Bandovkina Valeria , Gevorkyan Yuriy , Soldatkina Natalia , Dzhenkova Elena , Cheryarina Natalia , Goroshinskaya Irina , Samoilenko Nikolay , Shaposhnikov Aleksandr , Sidorenko Yuriy
Published: February 2022

Background. Hormones and their receptors are important effectors providing interconnection between the primary tumor and metastatic niches.
The aim of the study was to determine levels of prolactin (PRL), sex steroid binding globulin (SSBG), steroid hormones and their receptors in tissues of gastric cancer (GC), omentum and peritoneum.
Materials and methods. Levels of PRL, SSBG, steroid hormones and their receptors were determined by ELISA in tissues of primary tumors, omentum and peritoneum in main groups: 1 (M0) — GC T3–4аN0–3M0 (n=24) and 2 (M1) — GC T3–4аN0–3M1 (n=21); in tissues of the stomach, omentum and peritoneum — in the comparison group — non-cancer patients (n=17).
Results. GC (М0) was characterized by high levels of estrogen receptors (ER) α — by 1.2 times (p<0.05), progesterone (PR) — by 3.5 times and SSBG — by 1.4 times (p<0.05); tissues of the omentum and peritoneum showed increased levels of ERα — by 2.4 and 3.9 times, ERβ — by 1.5 (p<0.05) and 2.5 times, РR — by 2.2 and 1.5 times (p<0.05). GC (М1) had low ERα levels; in tissues of GC, omentum and peritoneum, estradiol was reduced — by 4.2, 4.0 and 8.6 times, respectively, free testosterone increased — by 18.9, 2.0 and 2.8 times, and PRL increased by 8.0, 7.6 and 1.7 times (p<0.05).
Conclusions. Elevated levels of receptors ERα, ERβ and РR in metastatic niches in GC can be considered one of the factors protecting tissues from metastatic colonization, and levels of ERα and РR in the niches correlate with their levels in tumor tissues in GC М1 and М0.
Mungkinkah Menyandingkan Idealisme dan Bisnis Media?
Authors: Satriani Arba'iyah
Published: February 2022

Dunia sedang berubah dengan cepat karena kemajuan teknologi yang pesat. Perusahaan media mengalami disrupsi yang luar biasa di tengah kemajuan teknologi tersebut. Disrupsi teknologi ini ditambah dengan situasi pandemi yang sudah berlangsung sejak 2020 silam. Dalam concept noteHari Kebebasan Pers Sedunia 2021, diungkapkan bahwa banyak perusahaan media mengalami tantangan finansial yang substantif di era ini. Hal tersebut mau tidak mau mempengaruhi keberlangsungan hidup media termasuk para awak medianya.
Meretas Lanskap Idealisme Jurnalis dan Inovasi Bisnis Industri Media
Authors: Alfani Hendra , Susanto Masayu Indriaty
Published: February 2022

Bisnis industri media dan profesi jurnalis atau wartawan, memasuki tahapan krusial. Masif-nya perkembangan teknologi informasi dan komunikasi yang berbasis internet, telah melahirkan “budaya” baru dalam tata kelola bisnis industri media dan perubahan habit dalam profesi kewartawanan.
Idealisme Wartawan dalam Pusaran Bisnis Media: Runtuhnya Dinding Api
Authors: Widyanningtyas Mia Dwianna
Published: February 2022

Duapuluh lima tahun lalu, saat saya menjadi wartawan, saya tidak pernah dipusingkan dengan urusan “idealisme”. Hal ini karena dalam setiap tugas liputan, dalam benak saya hanya ada satu tujuan yakni selalu ingin membuat berita yang baik, yang memenuhi unsur nilai berita dan tentu saja eksklusif. Hingga saya keluar dari profesi wartawan, saya tidak pernah tahu dan tidak pernah bersinggungan dengan urusan bisnis media tempat dimana saya bekerja. Kondisiini dimungkinkan karena pada masa itu kami, para wartawan, tidak pernah terlibat dengan urusan iklan dan memang tidak perlu tahu pendapatan media. Kala itu, ada sebuah garis batas yang dalam jurnalisme dikenal dengan istilah dinding api (firewall).
Idealisme Jurnalis dan Pertimbangan Moral Pemberitaan
Authors: Ohorella Noviawan Rasyid , Birahy Priska Akwila
Published: February 2022

Indonesia tidak bisa lepas dari perkembangan media, baik itu cetak maupun elektronik. Pemerintahan maupun masyarakat menjadikan media sebagai wadah komunikasi informasi. Dalam konteks ini Media terus berevolusi bukan sekedar memberitakan pencapaian pemerintah, tetapi mengakomodir kemauan dan apa saja yang dibutuhkan oleh masyarakat. Terlepas dari hal ini pers yang sebelumnya mengkonsepkan diri sebagai sebagai media pembangunan yang mengedepankan kekuasaan, berubah menjadi transparansi dan demokratisasi komunikasi informasi (Eko Harry, 2009).
Assessment of Psychiatric Issues in Post-concussion Syndrome
Authors: Rahman Md Moshiur , Rabin Farzana
Published: February 2022

The term "Post-Concussion Syndrome" (PCS) refers to a group of non-specific symptoms that occur after a concussion or Mild Traumatic Brain Injury (MTBI) and last longer than expected. Headaches, weariness, vertigo/dizziness, irritability, emotional lability or irritability, cognitive problems, sleep disturbance, anxiety, and depression are all possible symptoms. According to Silverberg and Iverson, both neurobiological and psychosocial factors influence symptoms during the early phases of recovery [1].
Association of eNOS and STAT6 Gene Polymorphisms with the Susceptibility of Polycystic Ovary Syndrome in South Indian Women
Authors: Bhanoori Manjula , KV Veena , Siddamalla Swapna , Guruvaiah Praveen , Venkat Reddy Tumu , Govatati Suresh , Deenadayal Mamata , Shivaji Sisinthy
Published: February 2022

Purpose: Polycystic Ovary Syndrome (PCOS) is a complex multifactorial endocrine metabolic disorder of reproductive-aged women characterized by hyperandrogenism, hirsutism, anovulation, hyperinsulinemia and polycystic ovaries. The main aim of this study was to investigate the association of eNOS and STAT6 gene Single Nucleotide Polymorphisms (SNPs) with the susceptibility of PCOS in South Indian Women. Research question: What is the association status of eNOS and STAT6 SNPs with PCOS? Methods: The present genetic association study involves clinically confirmed PCOS patients (n = 105) and non-PCOS controls (n = 110) of the Dravidian linguistic group. Genotyping of +894G/T (Glu298Asp) SNP of eNOS and 2964G/A SNP of STAT6 was performed by Polymerase Chain Reaction (PCR) and sequencing analysis. Results: There were statistically significant differences in the genotype and allele frequencies of eNOS+894G/T (p = 0.1110) and STAT62964G/A (0.0019) between the cases and controls, according to codominant, dominant and recessive genotype models. Conclusion: In conclusion, the eNOS and STAT6 gene polymorphisms may constitute an inheritable risk factor for PCOS in South Indian women.
High Affinity Peptides in Processes of IgG Purification, Chromatographic Column Virus Inactivation/Elimination and Titer of Anti-Rubella IgG Enrichment
Authors: Havryliuk Serhiy P , Krasnobryzha Ievhenia M , Havryliuk Olena S , Volkov* Heorgii L
Published: February 2022

According to "The Proteome Code" concept introduced by J. Biro and our early development of affinity peptide calculation method it was studied the possibility of high affinity peptide chromatographic gels development for IgG1-4 separation from the donor plasma. Given the next step of virus inactivation of IgG directly in the chromatographic column, the affinity gel had bind IgG at several spatially spaced points in order to limit the degree of freedom of the protein for retention IgG at high buffer flow rate or elevated buffer temperatures without denaturation. In addition, the possibility of creating highly specific affinity sense-antisense peptides against Rubella virus in order to increase the titer of aRIgG in plasma or even its isolation in highly purified form was studied. Based on previous experiments, an affinity multi-peptide chromatographic gel with the following properties was developed: the DBC with enough residence time 10 min was around 50-54 mg × mL-1 of total 98.0% purity of IgG with natural proportion of the 1-4 subclasses, any other immunoglobulins were not found. The virus inactivation/elimination on this gel directly in chromatographic column shown a highly effective virus elimination (log10>9) for both nonenveloped and lipid enveloped viruses. Using RV sequence from UniProt_KB and dates from more than 20 literature sources on the virus proteins interaction, affinity peptides were calculated against virus proteins C and E1,2. Then these peptides were modified to reach more affinity enhancement and affinity-peptide chromatographic gel was synthetized. By this gel from total mass IgG1-4 contained 6644 IU anti-Rubella IgG with specificity 6.64 IU × mg-1 were isolated 5382 IU aRIgG (> 80%) with a specificity of 791 IU × mg-1.
Current Knowledge and Awareness of Dengue Fever among Students of Government College University Faisalabad
Authors: Fayzan Muhammad , Abid Arslan , Nawaz Saira , Akram Muhammad , Khan Fahad Said , Muddasar Saeed Muhammad , Zafar Kianat , Khalil Muhammad Talha , Elkhateeb Waill , Daba Ghoson
Published: February 2022

Background: Dengue fever is a vector-borne infectious tropical disease caused by the dengue virus, the most common arthropod-borne infection in humans. According to WHO, the best strategy to avoid dengue endemic is to educate people about the disease and preventative measures? Despite the efforts to avoid the dengue virus, the newest national survey statistics show that dengue fever is still on the increase among the population. The major goal of this study was to examine university students' knowledge of dengue and preventative measures, as well as to determine the relationship between awareness of dengue and drivers of knowledge of dengue infection in Government College University Faisalabad students. Aim: The aim of this review is to highlight Dengue fever (break-borne fever). Materials and methods: This was a survey review article. This research work was conducted at Government College University, Faisalabad. And this research work was conducted in three months (Between February 2020 and April 2020). A cross-sectional study investigation was carried out. A total of 500 students were interviewed, with pre-tested questioners being used. Results: A cross-sectional investigation was carried out. A total of 500 students were interviewed, with pre-tested questioners being used. The sampling was done in a convenient manner. In Government College University Faisalabad, several medical terminologies were put in plain English, and interviewers were trained for data collecting. The research was carried out at Government College University in Faisalabad. The course of study was also thought to have an influence on Dengue fever knowledge. SPSS was used to examine the findings of this investigation. The total score range was 25. The participants (26.4%) showed scores from a range of 10 or below 10 which means they had poor knowledge about dengue awareness. While the participants (45.4%) showed scores from a range of 11 to 18 which means they had fair knowledge about dengue awareness. The participants (28.2%) s showed scores ranging from 19 to 25 which means they had good knowledge about dengue fever awareness. Conclusion: Of this study is that knowledge is poor between the study respondents while the majority of persons had clear understanding of fever, headache, joint pain as general signs and symptoms of dengue viral fever. However, a huge proportion exhibited vague opinions of other different signs and symptoms involving muscular pain and skin rashes. Only rare of them knew that dengue viral fever is caused by mosquito bites, and was conscious that the mosquito causing dengue breeds in artificially collected water.
Parkinsons Disease-Like Neuropathology and Phenotype Following Induction of Oxidative Stress and Inflammation in the Brain
Authors: Ehsanifar* Mojtaba , Montazeri Zeinab
Published: February 2022

Parkinson’s Disease (PD) is a neurodegenerative disorder characterized by motor deficits caused by the loss of dopaminergic neurons in the Substantia Nigra (SN) and Ventral Tegmental Area (VTA). However, clinical data revealed that not only the dopaminergic system is affected in PD. Pharmacological models support the concept that modification of noradrenergic transmission can influence the PD-like phenotype induced by neurotoxins. Exposure to ambient pollutants such as air pollutants also can be adversely impacted the Central Nervous System (CNS) by the activation of proinflammatory pathways and reactive oxygen species. Thus, targeting neuroinflammation and oxidative stress can be a useful strategy to eliminate the obvious symptoms of neurodegeneration. Overall, in the current mini-review, we examined the neuroprotective role of noradrenaline in the model of oxidative stress and neuroinflammation.
Haemolytic Anaemia Due to Early Failure of Mitral Valve Repair with Artificial Neochordae: A Technical Error
Authors: Ceresa Fabrizio , Rubino Antonino Salvatore , Zito Concetta , Patane Francesco
Published: February 2022

We report the case of an unexpected massive haemolysis occurred early after mitral valve repair. Potential underlying causes have been investigated, with review of the literature. After mitral valve replacement, haemolysis disappeared and the patient recovered, returning to normal life after 12 months.
STABILITY INDICATING RELATED SUBSTANCES METHOD FOR BISOPROLOL AND CILNIDIPINE IN BULK AND PHARMACEUTICAL DOSING TYPES AND ITS DEGRADENTS WERE CHARACTERISED BY USE OF LC-MS/MS
Authors:   Department of Chemistry, Acharya Nagarjuna University, Guntur-522510, AP, India., Yarlagadda Subba Rao , Mannam Subba Rao ,   Department of Chemistry, Acharya Nagarjuna University, Guntur-522510, AP, India., Padmavathi K. V ,   Department of Chemistry, D. S. Degree College for Women, Ongole, AP, India., Jampani Baby Padmini ,   Department of Chemistry, Dr. B. R. Ambedkar Gurukulam, Moturu, Gudivada, AP, India.
Published: February 2022

A reliable, simple yet consistent RP-HPLC method has been developed and verified to combined dosage form of Bisoprolol, Cilnidipine, their relavant substances and characteristic of the degradants by LC-MS/MS. The process used was optimized by using X-Bridge phenyl column (150mmx4.6mm, 3.5 µ) with a gradient elution mode of mobile phase consists of methanol and 0.1% tri ethyl amine of pH-2.5. The developed RP-HPLC method shows strong linearity in the range of concentrations 2-30 µg/ml of Bisoprolol, 4-60 µg/ml of Cilnidipine and 0.1-1.5 µg/ml of Bisoprolol and Cilnidipine impurities. Percentage of regeneration and percentage RSD values were found to be within the allowable limit. The developed method was found to be applicable for routine analysis and utilized for the calculation of both active ingredients and their impurities in tablet dosage form