bluuebunny/crossref_metadata_2025 huggingface dataset:
Diurnal rhythms in gene expression in the prefrontal cortex in schizophrenia
Authors: Seney Marianne L. , Cahill Kelly , Enwright John F. , Logan Ryan W. , Huo Zhiguang , Zong Wei , Tseng George , McClung Colleen A.
Published: August 2019

Schizophrenia is associated with disrupted cognitive control and sleep-wake cycles. Here we identify diurnal rhythms in gene expression in the human dorsolateral prefrontal cortex (dlPFC), in schizophrenia and control subjects. We find significant diurnal (24 h) rhythms in control subjects, however, most of these transcripts are not rhythmic in subjects with schizophrenia. Instead, subjects with schizophrenia have a different set of rhythmic transcripts. The top pathways identified in transcripts rhythmic only in subjects with schizophrenia are associated with mitochondrial function. Importantly, these rhythms drive differential expression patterns of these and several other genes that have long been implicated in schizophrenia (including BDNF and GABAergic-related transcripts). Indeed, differential expression of these transcripts is only seen in subjects that died during the night, with no change in subjects that died during the day. These data provide insights into a potential mechanism that underlies changes in gene expression in the dlPFC with schizophrenia.
The new-generation selective ROS1/NTRK inhibitor DS-6051b overcomes crizotinib resistant ROS1-G2032R mutation in preclinical models
Authors: Katayama Ryohei , Gong Bo , Togashi Noriko , Miyamoto Masaya , Kiga Masaki , Iwasaki Shiho , Kamai Yasuki , Tominaga Yuichi , Takeda Yasuyuki , Kagoshima Yoshiko , Shimizu Yuki , Seto Yosuke , Oh-hara Tomoko , Koike Sumie , Nakao Naoki , Hanzawa Hiroyuki , Watanabe Kengo , Yoda Satoshi , Yanagitani Noriko , Hata Aaron N. , Shaw Alice T. , Nishio Makoto , Fujita Naoya , Isoyama Takeshi
Published: August 2019

ROS1 gene rearrangement was observed in around 1–2 % of NSCLC patients and in several other cancers such as cholangiocarcinoma, glioblastoma, or colorectal cancer. Crizotinib, an ALK/ROS1/MET inhibitor, is highly effective against ROS1-rearranged lung cancer and is used in clinic. However, crizotinib resistance is an emerging issue, and several resistance mechanisms, such as secondary kinase-domain mutations (e.g., ROS1-G2032R) have been identified in crizotinib-refractory patients. Here we characterize a new selective ROS1/NTRK inhibitor, DS-6051b, in preclinical models of ROS1- or NTRK-rearranged cancers. DS-6051b induces dramatic growth inhibition of both wild type and G2032R mutant ROS1–rearranged cancers or NTRK-rearranged cancers in vitro and in vivo. Here we report that DS-6051b is effective in treating ROS1- or NTRK-rearranged cancer in preclinical models, including crizotinib-resistant ROS1 positive cancer with secondary kinase domain mutations especially G2032R mutation which is highly resistant to crizotinib as well as lorlatinib and entrectinib, next generation ROS1 inhibitors.
Plasticity without dislocations in a polycrystalline intermetallic
Authors: Luo Hubin , Sheng Hongwei , Zhang Hongliang , Wang Fengqing , Fan Jinkui , Du Juan , Ping Liu J. , Szlufarska Izabela
Published: August 2019

Dislocation activity is critical to ductility and the mechanical strength of metals. Dislocations are the primary drivers of plastic deformation, and their interactions with each other and with other microstructural features such as grain boundaries (GBs) lead to strengthening of metals. In general, suppressing dislocation activity leads to brittleness of polycrystalline materials. Here, we find an intermetallic that can accommodate large plastic strain without the help of dislocations. For small grain sizes, the primary deformation mechanism is GB sliding, whereas for larger grain sizes the material deforms by direct amorphization along shear planes. The unusual deformation mechanisms lead to the absence of traditional Hall-Petch (HP) relation commonly observed in metals and to an extended regime of strength weakening with grain refinement, referred to as the inverse HP relation. The results are first predicted in simulations and then confirmed experimentally.
Transition metal-free phosphonocarboxylation of alkenes with carbon dioxide via visible-light photoredox catalysis
Authors: Fu Qiang , Bo Zhi-Yu , Ye Jian-Heng , Ju Tao , Huang He , Liao Li-Li , Yu Da-Gang
Published: August 2019

Catalytic difunctionalization of alkenes has been an ideal strategy to generate structurally complex molecules with diverse substitution patterns. Although both phosphonyl and carboxyl groups are valuable functional groups, the simultaneous incorporation of them via catalytic difunctionalization of alkenes, ideally from abundant, inexpensive and easy-to-handle raw materials, has not been realized. Herein, we report the phosphonocarboxylation of alkenes with CO2via visible-light photoredox catalysis. This strategy is sustainable, general and practical, providing facile access to important β-phosphono carboxylic acids, including structurally complex unnatural α-amino acids. Diverse alkenes, including enamides, styrenes, enolsilanes and acrylates, undergo such reactions efficiently under mild reaction conditions. Moreover, this method represents a rare example of redox-neutral difunctionalization of alkenes with H-P(O) compounds, including diaryl- and dialkyl- phosphine oxides and phosphites. Importantly, these transition-metal-free reactions also feature low catalyst loading, high regio- and chemo-selectivities, good functional group tolerance, easy scalability and potential for product derivatization.
Protein determinants of dissemination and host specificity of metallo-β-lactamases
Authors: López Carolina , Ayala Juan A. , Bonomo Robert A. , González Lisandro J. , Vila Alejandro J.
Published: August 2019

The worldwide dissemination of metallo-β-lactamases (MBLs), mediating resistance to carbapenem antibiotics, is a major public health problem. The extent of dissemination of MBLs such as VIM-2, SPM-1 and NDM among Gram-negative pathogens cannot be explained solely based on the associated mobile genetic elements or the resistance phenotype. Here, we report that MBL host range is determined by the impact of MBL expression on bacterial fitness. The signal peptide sequence of MBLs dictates their adaptability to each host. In uncommon hosts, inefficient processing of MBLs leads to accumulation of toxic intermediates that compromises bacterial growth. This fitness cost explains the exclusion of VIM-2 and SPM-1 from Escherichia coli and Acinetobacter baumannii, and their confinement to Pseudomonas aeruginosa. By contrast, NDMs are expressed without any apparent fitness cost in different bacteria, and are secreted into outer membrane vesicles. We propose that the successful dissemination and adaptation of MBLs to different bacterial hosts depend on protein determinants that enable host adaptability and carbapenem resistance.
MOD-LSP, MODIS-based parameters for hydrologic modeling of North American land cover change
Authors: Bohn Theodore J. , Vivoni Enrique R.
Published: August 2019

Earth systems models require gridded land surface properties to compute fluxes of water, energy, and carbon within the landscape and to the atmosphere. However, most parameter sets contain time-invariant properties despite their known variability. Here we present new MODerate Resolution Imaging Spectroradiometer (MODIS)-based land surface parameters (MOD-LSP) formatted for the Variable Infiltration Capacity (VIC) hydrologic model that account for seasonal and interannual variability and longer-term change over the continental United States, Mexico, and southern Canada at 0.0625° spatial resolution and monthly temporal resolution. MOD-LSP improves over previously-available parameter sets via: (1) land cover maps of higher native spatial resolution; (2) multiple versions corresponding to the land cover of years 1992, 2001, and 2011; (3) spatially-explicit mean annual cycles of land surface properties, including leaf area index, canopy fraction, and albedo, derived from 17 years of observations; and (4) additional 17-year time series of these properties. The MOD-LSP parameters are useful as inputs to the VIC model, as an example land surface scheme, to assess the hydrologic impacts of land cover change from interannual to decadal scales; and as stand-alone datasets characterizing the temporal variability of these properties as a function of land cover class.
Intelligent Metal-Phenolic Metallogels as Dressings for Infected Wounds
Authors: Anh Ha Thi Phuong , Huang Chun-Ming , Huang Chun-Jen
Published: August 2019

In this study, we report a metallogel developed based on metal-phenolic coordination of natural low-cost polyphenolic molecule and metal ions. Gelation occurs by mixing tannic acid (TA) and group (IV) titanium ions (TiIV) to form TA-TiIV gel. The TA-TiIV gel exhibits good capability to incorporate diverse metal ions by in situ co-gelation. Herein, five antimicrobial metal ions, i.e. ferric (FeIII), copper (CuII), zinc (ZnII), cobalt (CoII) and nickel (NiII) ions, were employed to include in TA-TiIV gels for developing intelligent dressings for infected wounds. The chemical and coordinative structures of TA-TiIV metallogels were characterized by UV-Vis and Fourier-transform infrared (FT-IR) spectroscopies. Cytotoxicity of antimicrobial metallogels was explored by MTT assay with NIH 3T3 fibroblasts. The release of metal ions was evaluated by inductively coupled plasma mass spectrometry (ICP-MS), indicating the different releasing profiles upon the coordinative interactions of metal ions with TA. The formation and disassembly of metallogels are sensitive to the presence of acid and an oxidizer, H2O2, which are substances spontaneously generated in infected wounds due to the metabolic activity of bacteria and the intrinsic immune response. The CuII releasing rates of TA-TiIV-CuII metallogels at different pH values of 5.5, 7.4 and 8.5 have been studied. In addition, addition of H2O2 trigger fast release of CuII as a result of oxidation of galloyl groups in TA. Consequently, the antimicrobial potency of TA-TiIV-CuII metallogels can be simultaneously activated while the wounds are infected and healing. The antimicrobial property of metallogels against Gram-negative Escherichia coli, and Gram-positive Methicillin-Resistant Staphylococcus aureus (USA300) and Staphylococcus epidermidis has been investigated by agar diffusion test. In an animal model, the TA-TiIV-CuII metallogels were applied as dressings for infected wounds, indicating faster recovery in the wound area and extremely lower amount of bacteria around the wounds, compared to TA-TiIV gels and gauze. Accordingly, the intelligent nature derived metallogels is a promising and potential materials for medical applications.
Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling
Authors: Zhao Kening , Bleackley Mark , Chisanga David , Gangoda Lahiru , Fonseka Pamali , Liem Michael , Kalra Hina , Al Saffar Haidar , Keerthikumar Shivakumar , Ang Ching-Seng , Adda Christopher G. , Jiang Lanzhou , Yap Kuok , Poon Ivan K. , Lock Peter , Bulone Vincent , Anderson Marilyn , Mathivanan Suresh
Published: August 2019

Extracellular vesicles (EVs) are membranous vesicles that are released by cells. In this study, the role of the Endosomal Sorting Complex Required for Transport (ESCRT) machinery in the biogenesis of yeast EVs was examined. Knockout of components of the ESCRT machinery altered the morphology and size of EVs as well as decreased the abundance of EVs. In contrast, strains with deletions in cell wall biosynthesis genes, produced more EVs than wildtype. Proteomic analysis highlighted the depletion of ESCRT components and enrichment of cell wall remodelling enzymes, glucan synthase subunit Fks1 and chitin synthase Chs3, in yeast EVs. Interestingly, EVs containing Fks1 and Chs3 rescued the yeast cells from antifungal molecules. However, EVs from fks1∆ or chs3∆ or the vps23∆chs3∆ double knockout strain were unable to rescue the yeast cells as compared to vps23∆ EVs. Overall, we have identified a potential role for yeast EVs in cell wall remodelling.
Carboxylic acid induced near-surface restructuring of a magnetite surface
Authors: Arndt Björn , Sellschopp Kai , Creutzburg Marcus , Grånäs Elin , Krausert Konstantin , Vonk Vedran , Müller Stefan , Noei Heshmat , Feldbauer Gregor B. V. , Stierle Andreas
Published: August 2019

A fundamental knowledge of the interaction of carboxylic acids, such as formic acid, with magnetite surfaces is of prime importance for heterogeneous catalysis and the synthesis of novel materials. Despite this, little is known about the atomic scale adsorption mechanisms. Here we show by in-situ surface X-ray diffraction that the oxygen rich subsurface cation vacancy reconstruction of the clean magnetite (001) surface is lifted by dissociative formic acid adsorption, reestablishing a surface with bulk stoichiometry. Using density functional theory, the bulk terminated, fully formic acid covered surface is calculated to be more stable than the corresponding clean, reconstructed surface. A comparison of calculated and experimental infrared bands supports the bidentate adsorption geometry and a specific adsorption site. Our results pave the way for a fundamental understanding of the bonding mechanism at carboxylic acid/oxide interfaces.
Experimental and computational approaches to produce and characterise isostructural solvates
Authors: Braun Doris E. , Gelbrich Thomas , Griesser Ulrich J.
Published: August 2019

A combination of experiment and theory was applied to rationalise the formation, stability and phase transitions of isostructural dapsone hemisolvates. Critical solvent properties as well as structural and energetic features are discussed.
Five new coordination polymers with a Y-shaped N-heterocyclic carboxylic acid: structural diversity, bifunctional luminescence sensing and magnetic properties
Authors: Liang Jinxia , Zhang Jie , Liang Jinfang , Zhai Lijun , Wu Haonan , Niu Xiaoyan , Hu Tuoping
Published: August 2019

Five novel CPs have been synthesized under solvothermal conditions. The results show that 1 and 2 present high sensing ability for NACs and Fe3+ ions, and there exist ferromagnetic interaction in 3/4 and antiferromagnetic interaction in 5.
Theobromine cocrystals with monohydroxybenzoic acids – synthesis, X-ray structural analysis, solubility and thermal properties
Authors: Gołdyn Mateusz , Larowska Daria , Nowak Weronika , Bartoszak-Adamska Elżbieta
Published: August 2019

Theobromine, a compound from the purine alkaloid group, is much less soluble in polar solvents than its analogues,i.e.caffeine and theophylline, that is why it was used as an active pharmaceutical ingredient (API) model in cocrystal preparation.
Rigid hindered N-heterocyclic carbene palladium precatalysts: synthesis, characterization and catalytic amination
Authors: Zhang Fei-Yi , Lan Xiao-Bing , Xu Chang , Yao Hua-Gang , Li Tian , Liu Feng-Shou
Published: August 2019

Rigid hindered N-heterocyclic carbene palladium complexes have been developed and exhibited high activities for a variety of (hetero)aryl chlorides with (hetero)anilines and amines under aerobic conditions.
Oxidant-controlled divergent transformations of 3-aminoindazoles for the synthesis of pyrimido[1,2-b]-indazoles and aromatic nitrile-derived dithioacetals
Authors: Zhou Yao , Lou Yixian , Wang Ya , Song Qiuling
Published: August 2019

An oxidant-controlled divergent reactivity of 3-aminoindazoles is presented, which enables the [3 + 3] annulation and C–H arylation of ketene dithioacetals in disparate pathways to assemble pyrimido[1,2-b]-indazoles and aromatic nitrile-derived dithioacetals.
Functionalization of theranostic AGuIX® nanoparticles for PET/MRI/optical imaging
Authors: Thakare Vivek , Tran Vu-Long , Natuzzi Marco , Thomas Eloïse , Moreau Mathieu , Romieu Anthony , Collin Bertrand , Courteau Alan , Vrigneaud Jean-Marc , Louis Cédric , Roux Stéphane , Boschetti Frédéric , Tillement Olivier , Lux François , Denat Franck
Published: August 2019

The controlled dual functionalization of AGuIX® nanoparticles afforded trimodal imaging (PET/MRI/fluorescence) theranostic agents.
High-sulfur coal-derived nitrogen, sulfur dual-doped carbon as an economical metal-free electrocatalyst for oxygen reduction reaction
Authors: Geng Jing , Zhang Hui-Juan , Yao Sunwu , Cai Chunlei , Ma Zi-Feng , Wang Jiancheng , Wei Haibing , Yang Junhe
Published: August 2019

The search for an economical electrocatalyst for oxygen reduction reaction (ORR) is a worldwide issue for fuel cells and metal–air batteries.
A noble-metal-free photocatalyst system obtained using BODIPY-based MOFs for highly efficient visible-light-driven H2 evolution
Authors: Yang Heng , Zhao Ming , Zhang Jing , Ma Ji , Wu Pengyan , Liu Wenlong , Wen Lili
Published: August 2019

This study provides fundamental insights into the role of porosity in photocatalytic activity and might inform the ongoing efforts toward the noble-metal-free photocatalytic systems via BODIPY-based MOFs for visible-light-promoted H2 evolution.
Hydrophobic AgNPs: one-step synthesis in aqueous solution and their greatly enhanced performance for SERS detection
Authors: Peng Qianqian , Wang Na , Zhu Yue , Hu Jing , Peng Huaqiao , Li Lin , Zheng Baozhan , Du Juan , Xiao Dan
Published: August 2019

Hydrophobic AgNPs have been one step synthesized in aqueous solution at ambient conditions for the first time, which could be used for constructing SERS substrate with greatly enhanced SERS properties.
Hollow porous Fe2O3 microspheres wrapped by reduced graphene oxides with high-performance microwave absorption
Authors: Wang Lei , Zhang Jie , Wang Min , Che Renchao
Published: August 2019

Hollow porous Fe2O3 microspheres wrapped by thin RGO sheets exhibited high-performance microwave absorption with a reflection loss value of −48.1 dB and an effective absorption bandwidth cover of 5.28 GHz.
Early Language Interventions for Young Dual Language Learners: A Scoping Review
Authors: Guiberson Mark , Ferris Kyliah Petrita
Published: August 2019

Purpose

The aim of this article was to provide a systematic scoping review of the literature describing early language interventions for young children who are dual language learners, including children with early language deficits.

Method

The search conducted yielded a total of 27 sources describing 70 language strategies or procedures for dual language learners from 9 months of age to 3 years 11 months of age. The majority of sources were recommended practices (
n
= 12) followed by descriptive studies (
n
= 7). There were a total of 6 intervention studies and 5 research review studies.

Results

Strategies were collated and categorized into 5 major types: general approach, caregiver based, interaction based, language strategies, and early literacy strategies.

Conclusion

A preliminary evidence map was created to chart each strategy and sources that included the strategy and to indicate the highest strength of recommendation observed across sources. A discussion of compelling and promising strategies is presented.
Low‐loss broadband (DC to 220 GHz) S‐CPW to S‐CPS transition for S‐CPS coplanar probing
Authors: Saadi A.A. , Margalef‐Rovira M. , Vincent L. , Lepilliet S. , Gaquiere C. , Ferrari P.
Published: August 2019

The practical issue of probing coplanar stripline (CPS) structures is addressed in this Letter. A compact slow‐wave coplanar waveguide (S‐CPW) to slow‐wave CPS (S‐CPS) transition was designed and fabricated in a 55 nm BiCMOS process of STMicroelectronics. The signal strips of the slow‐wave CPW and slow‐wave CPS have been directly connected while the ground strips have been tied together through combination of transmission lines laid out on the top metal layer of the back‐end‐of‐line of the technology. Thanks to its flexibility, the proposed transition can be resized to match with a wide range of slow‐wave CPS slot. Tested from DC to 220 GHz, the back‐to‐back transition structure showed insertion loss lower than 1.4 dB and return loss better than 15 dB, respectively. To the best of author's knowledge, it is the first integrated slow‐wave CPW/CPS transition introduced within the mentioned mm‐wave band.
Frequency measurement approach based on linear model for increasing low SNR sinusoidal signal frequency measurement precision
Authors: Tan Chao , Yue Zhoumei , Wang Jiacheng
Published: August 2019

In order to improve the frequency measurement accuracy of low signal‐to‐noise ratio (SNR) sinusoidal signal, a frequency measurement approach based on a linear model is proposed. Firstly, the precision of frequency measurement affected by random noise while transforming the wave is analysed. Then, a linear model of frequency measurement is established according to the characteristics of frequency measurement, and the model is fitted by least‐square regression analysis with the measured data of several periods. Finally, the formula for frequency calculation is obtained from the regression results, and the relative error of frequency measurement is deduced and compared with other method. Simulation results and frequency measurement experimental results show that, the proposed method can effectively suppress noise and improve the frequency measurement accuracy of low SNR sinusoidal signal.
Smart coordination schemes for multiple battery energy storage systems for support in distribution networks with high penetration of photovoltaics
Authors: Unigwe Obinna , Okekunle Dahunsi , Kiprakis Aristides
Published: August 2019

The use of battery energy storage system (BESS) is one of the methods employed in solving the major challenge of overvoltage, experienced on distribution networks with high penetration of photovoltaics (PV). The overvoltage problem limits the penetration levels of PV into the distribution network, and the benefits that could be gained. This study presents three loosely‐related schemes for the coordination of multiple BESSs in such networks. Through the efficient selection, coordination and timing of charge and discharge operations of the BESS, the scheme maintains bus voltages within statutory ranges during periods of high PV power generation and high network load demand. Network segmentation was used in two of the schemes to encourage more even utilisation of the BESS in order to maximise the economic benefits of the BESS. The algorithms for the schemes were implemented and demonstrated on two different distribution networks. Simulation results showed that the schemes met the objectives of mitigating overvoltage and more even cycling of the BESSs during their operating lifetimes.
SAR image target‐detection method based on two‐stage CFAR detector with G0 distribution
Authors: Fu‐qing Cai , Jie Song , Heng‐yan Liu , Wei Xiong
Published: August 2019

CFAR detection algorithm is widely used in the typical target detection of SAR images. In SAR image target detection, the simple statistical distribution models, such as Gaussian distribution, normal distribution, Weibull distribution etc., are obviously not suitable for the fitting of the background clutter distribution of missile‐borne SAR images, and the G 0 distribution is suitable for extremely unstable regions and its expression is relatively simple. A two‐stage CFAR detector with G 0 distribution is designed and the distribution of ground SAR images is statistically analysed by using the CA‐CFAR detector. A target in a relatively non‐homogenous background usually has a long tail, and the detection results of the two‐stage CFAR detector based on the G0 distribution are much better.
Wavefront curvature compensation in PFA for spotlight bistatic SAR with arbitrary platforms paths
Authors: Miao Yuxuan , Chen Tianfu , Wu Junjie , Yang Jianyu
Published: August 2019

Polar format algorithm (PFA) as is an efficient algorithm can be well applied to spotlight bistatic synthetic aperture radar (SAR). However, a planar wavefront assumption which leads to image distortion is made. In this study, a new method to compensate for the wavefront curvature of PFA image is presented and it can well correct the defocusing effect and geometry distortion even under arbitrary platforms paths. By projecting the coefficients of Taylor expansion from the azimuth‐time domain to wavenumber domain, the new method does not need repeated interpolations to construct the compensation filters for all the errors, which can decrease computational expense in a way. Finally, the effectiveness of this method is verified by numerical simulation.
High‐resolution imaging for the multireceiver SAS
Authors: Zhang Xuebo , Ying Wenwei , Dai Xuntao
Published: August 2019

The area coverage rate is dramatically improved by using the multireceiver technique. However, this configuration leads to the complexity of the synthetic aperture image formation. In order to solve this issue, the target based on the phase centre approximation (PCA) is to be reconstructed. The data related to the multireceiver SAS system is coerced into the data like traditional monostatic synthetic aperture sonar (SAS) system. Then, the data can be processed by traditional imaging methods. In this paper, the chirp scaling algorithm is exploited as an example. Moreover, the influence of some important steps with the monostatic conversion, i.e. pulse compression in the range dimension and the micro range cell migration correction (RCMC), is further discussed in detail. The simulations show that the presented method can focus the target well.
A study of accretion and disk diagnostics in the NGC 2264 cluster
Authors: Sousa Alana P. , Alencar Silvia H. P. , Rebull Luisa M. , Espaillat Catherine C. , Calvet Nuria , Teixeira Paula S.
Published: August 2019

Context. Understanding disk dissipation is essential for studying how planets form. Disk gaps and holes, which almost correspond to dust-free regions, are inferred from infrared observations of T Tauri stars (TTS), indicating the existence of a transitional phase between thick accreting disks and debris disks. Transition disks are usually referred to as candidates for newly formed planets.

Aims. We searched for transition disk candidates belonging to NGC 2264. Using stellar and disk parameters obtained in the observational multiwavelength campaign CSI 2264, we characterized accretion, disk, and stellar properties of transition disk candidates and compared them to systems with a full disk and diskless stars.

Methods. We modeled the spectral energy distribution (SED) of a sample of 401 TTS, observed with both CFHT equipped with MegaCam and IRAC instrument on the Spitzer, with Hyperion SED fitting code using photometric data from the U band (0.3 μm) to the Spitzer/MIPS 24 μm band. We used the SED modeling to distinguish transition disk candidates, full disk systems, and diskless stars.

Results. We classified ∼52% of the sample as full disk systems, ∼41% as diskless stars, and ∼7% of the systems as transition disk candidates, among which seven systems are new transition disk candidates belonging to the NGC 2264 cluster. The sample of transition disk candidates present dust in the inner disk similar to anemic disks, according to the αIRAC classification, which shows that anemic disk systems can be candidate transition disks. We show that the presence of a dust hole in the inner disk does not stop the accretion process since 82% of transition disk candidates accrete and show Hα, UV excess, and mass accretion rates at the same level as full disk systems. We estimate the inner hole sizes, ranging from 0.1 to 78 AU, for the sample of transition disk candidates. In only ∼18% of the transition disk candidates, the hole size could be explained by X-ray photoevaporation from stellar radiation.
Experimental methodology for tinplate rolling on a laboratory mill
Authors: Karmazina Iryna , Kukhar Volodymyr , Balalayeva Elena , Larkina Alla , Kashintseva Valentina
Published: August 2019

The review of cold rolling mills used for the production of tinplate and thin tinplate in the world is presented. World tinplate production is characterized by the desire to reduce the thickness of its steel base. In connection with the variety of tinplate rolling mills, peculiarities of the deformation conditions of thin tinplate, complexity of the technological process and theoretical prediction of the rolling process indices, especially in terms of the theoretical model universality, as well as paucity of existing practical data, the necessity of experimental research is substantiated. Experimental research methodology of energy and force modes for tinplate and thin tinplate rolling for different cold rolling mills: five-, six- and seven-stand, was developed. Deformation modes have been developed that allow simulating the process of continuous cold rolling of tinplate with a thickness of 0.16 mm and 0.28 mm in five-, six- and sevenstand mills, respectively. The technical characteristics of industriallaboratory equipment involved in experimental research are presented. The results of the chemical composition and mechanical properties investigation of the initial blank are presented. Experimental research of energy and force modes for tinplate rolling at different parameters of cold rolling mills using the developed methodology will determine their optimal combination, as well as justify the choice of rolling equipment in terms of energy efficiency of the rolling process and the quality of the strip.
Energy efficiency with the use of innovative materials in the Far North, using CAD
Authors: Begich Yasmin , Babanina Anna , Ziiaeva Kristina , Barinov Sergey
Published: August 2019

The relevance of this work lies primarily in the importance of this issue in the construction field. According to statistics, construction projects consume 40% of world energy. Industrial and residential buildings are becoming one of the main sources of thermal emissions of carbon dioxide into the atmosphere. The second argument in favor of relevance is the use of basalt composite reinforcement for brickwork. And the third argument can be the use of CAD to simulate the energy consumption of the building. The practical value of the work is to use the recommendations for the construction and reconstruction of energy efficient buildings located in the Arctic zone. The theoretical value of the developed model and the proposed technology for determining energy efficiency indicators will allow it to be used for further calculations.
Regularities of changes in material properties for some polymer-concrete ratios
Authors: Ilyin Aleksandr , Permyakov Mikhail , Andreyev Vladimir , Krasnova Тamara
Published: August 2019

Nuclear power has important fundamental features that are absent in other power generation technologies, since nuclear fuel has million times larger energy content, while nuclear waste is relatively low in volume, which makes it reliably localizable. This paper presents a study of the strength and electrical insulation properties of polymer concretes in a wide range of altering the polymer-concrete ratios. The analysis has identified an optimal polymer-cement composition for electrical insulation. It is herein demonstrated that polymer cements can be used for insulation of electromagnets. The tasks of creating new materials that meet the requirements of the time, the development of technologies that go beyond the solution of standard practical problems of the construction industry, and, accordingly, the emergence of related problems are the picture of modernity. This paper is useful for further developments in the construction industry, designed to solve the problems of using modern technologies and materials that have a negative impact on the environment. Thus, this allows the application of this approach in complex construction situations, including when working in environmentally complex areas, for leveling radiation.
4D BIM for Construction Planning and Environmental Planning
Authors: Sheina Svetlana , Seraya Ekaterina , Krikunov Viktor , Saltykov Nikita
Published: August 2019

In order to develop an algorithm for selecting the most optimal organizational and technical solutions during design process, and the following automatization of this process, the problem of using 4D modeling programs in the organization and technology of construction is considered. A 4D -model cannot exist without detailed 3D-model and allows taking into account different variable factors in real time. In addition, software that uses 4D-modeling makes it possible to reduce significantly the time needed to prepare a project, to take into account flaws and mistakes at the different design stages. The concept of the 4D model connects in real time the elements of the model with the elements of the plan, which are recorded by means of programming. Algorithm proposed by us includes a control-system, when each subsequent stage implies the complete completion of the previous one. Unlike traditional design technology, when the object options may differ in the scope of work, preliminary cost, etc., the use of a simplified 4D model allows pre-determining the best option. Also, BIM technology minimizes time costs by allowing designers and geodesic surveyors to work together. The information collected in the 4D model is saved by the operation company and is used during the operation of the object. The 4D programming allows us to optimize production processes, to visualize the construction of objects, and to solve the problems of the economic efficiency of the real estate objects construction with a high degree of probability.
Electric bus in Tyumen: the chase for trends and problems of exploitation
Authors: Petrov Artur , Petrova Daria
Published: August 2019

The article considers the issues of the progressive development of electric transport in the world and in Russia. The special accent was placed on analysis of electric buses promotion for the city passenger transport market. The history (facts, chronology) of attempts of electric buses exploitation in Russian cities is considered. The information about the technical solutions used in electric buses is given. Data on the economic aspects of electric buses exploitation is presented. We consider the experience of technical exploitation of electric bus LiAZ-6274 in Tyumen and provide information about specifics of technical rejections of this bus during 11 months of usage. President of GAZ Group V. Sorokin and driver of Passenger Motor Transport Enterprise № 1 in Tyumen who worked on the electrical bus gave their opinion on the issues of electric transport in Russia. In conclusion, advantages and drawbacks of electric buses exploitation in Russia at the current moment are considered.
A new approach to the design of preschool institutions
Authors: Filanova Tatiana V. , Zhuravlev Mikhail Yu. , Mikhaylova Ekaterina A.
Published: August 2019

The paper considers a new approach to the design of preschool institutions, taking into account the psychology of children's perception. The basic principles of creating the environment, motivating children to study, developing their mental, creative and physical abilities were identified. Buildings of preschool institutions are seen as means of the world perception and social adaptation of children. The child perceives the world through visual, tactile and other sensations. All factors of changing world should be reflected in the architectural style of a building. The paper defines principles of designing preschool institutions based on numerous studies of architects and psychologists: it is proposed to create projects for children, which will function as “giant space for games” with an open plan, and child-sized friendly corners as well. It is necessary to provide visual variety of forms, to use playful elements as a part of the façade, to convert the walking paths into the playground, and also to use the ecological approach in the design.
Determining the quality of continuous casting from billet caster
Authors: Androsenko Maria , Kulikova Ekaterina , Tyuteryakov Nail , Reshetnikova Elena , Pashenko Konstantin , Yaroslavtsev Alexey
Published: August 2019

There are various methods and practical examples to determine and to evaluate the production quality level. They include measuring, sensory, calculation, data-recording, sociological and expert methods. Among the variety of general-purpose statistical methods, only seven of them are chosen, which are applied by different specialists. They allow timely detecting and showing the problems, revealing the main points to start with, and helping to distribute the efforts to effectively fulfill main tasks.
Effect of ettringite morphology on the properties of expanding cement systems
Authors: Kharchenco Igor , Alekseev Vyacheslav
Published: August 2019

The effect of the pH of the reaction solution on the crystallization process and the ettringite morphology is theoretically substantiated and experimentally proved. Using physical and chemical research methods, the dependence of the morphology of crystallizing ettringite on the pH value of the reaction solution was established. It has been established that by introducing mineral micro fillers into the composition of expanding cement, it is possible to actively influence the pH value, the morphology of the resulting ettringite, the expansion kinetics, and the strength of cement stone and concrete based on it. The studies of the technical properties of concrete on the basis of expanding cements of various types have shown that with the introduction of micro fillers into the concrete composition, which intensify volume expansion during hydration of cement stone at the building site or factories for the production of ready-mixed concrete, it is possible to control the kinetics and extent of expansion, expansion pressure, deformative and strength characteristics of concrete and reinforced concrete structures.
Factors to improve the efficiency of a vertical screw mixer of bulk materials
Authors: Cherkasov Roman , Adigamov Kasyan , Pershin Victor , Cherepenko Arkady
Published: August 2019

The paper shows that it is possible to increase the efficiency of a vertical screw mixer of bulk materials and reduce costs by determining the required size of the feeding hole in the lower part of the casing, as well as by installing a screw flange with a reverse winding in relation to the screw spiral inside the screw casing and by installing a replaceable tip with a variable lead angle at the lower end of the screw. The analysis of the process of screw loading in the hopper allowed us to obtain an analytical dependence to determine the required size of the feeding hole, in which mixed materials freely enter the screw spiral. It is proved that the placement of the screw flange on the inner surface of the casing increases the driving force of material by 1.05 – 1.80 times depending on the screw speed, which significantly reduces specific energy consumption for preparation of mixture of the desired quality. The paper provides the formula for calculating the angle of installation of the flange with respect to the screw spiral, in which the maximum effect of the flange on the mixed materials is obtained. In order to ensure the effective capture of mixed materials in the loading zone of the screw, it is proposed to perform the first spiral turn from the lower end of the screw with a variable lead angle and place it on a replaceable tip. A technical solution to the placement of spirals on the double-threaded screw is also proposed.
Bionics and the choice of rational structural form
Authors: Mayatskaya Irina , Eremin Victor
Published: August 2019

The work is devoted to the development of such an interesting topic as bionics. The relevance of the study of this topic is due to the processes taking place both in our country and in the world. The aim of the work is to study the laws of formation of living organisms, their structure, design features, principles of operation and the use of this knowledge in the design of structures and constructions. The paper considers different areas of bionics and analyzes bionic principles. Particular attention is paid to architectural bionics in terms of the choice of optimal design. The study of natural objects allows creating structures and constructions that take into account properties, shape, structure, organization of life of living organisms and plants. The issues of creation of an optimum design are considered. To do this, it must have the following properties: reliability, durability, efficiency, maintainability, and of course, environmental friendliness. The paper provides the analysis of trends in bionics. It is worth noting that these trends are penetrating each other, creating a new one. The examples of constructions based on bionic principles are given. To solve this problem, it is necessary to apply methods of mathematical modeling. They allow choosing the best option using a numerical experiment. The results of the analysis of the problem can be used in the design of structures and constructions of unique structures, and should serve the further development of bionic science. The combination of bionic principles and optimization methods creates the basis for such developments.
Rating estimation of sustainability in the construction of high-rise building
Authors: Sheina Svetlana , Belash Vladimir , Ulianskaia Vera
Published: August 2019

The paper presents an assessment of a unique high-rise building according to the environmental certification system STO NOSTROY 2.35.4-2011 (Russia). Certification system of sustainable environment is described with the estimated criteria. An assessment of the existing European high-rise building adapted to the regional conditions of Rostov-on-Don in accordance with the specified standard was made. Result of preliminary assessment of building is shown. And the building parameters, work with which could increase the overall rating of certification, are emphasized.
Fine ground granulated blast furnace slag for saving quantity of binder
Authors: Kazanskaya Liliya , Privalov Nicolay , Privalova Svetlana
Published: August 2019

Nowadays, it is acknowledged that the use of mineral additives based on ground slag is one of ways of resource saving and improvement of technical properties of cement composites. Mineral additives with fineness similar to the Portland cement fineness are often used to replace part of Portland cement. Two kinds of ultra-fine ground granulated blast furnace slag that differ in composition and fineness were studied in the paper. Water-reduction due to effect of super plasticizer in slag-Portland cement compositions with amount of slag up to 70% was studied. The results of reduction of binder quantity per 1 kg of chemical admixture due to significant water-reduction are obtained and analysed. Correlations depending on kind, amount and fineness of slags, as well as depending on mineralogical composition of Portland cement were stated. The ultra-fine mineral additives based on ground slag with high specific surface area can be used for significant reduction of compositional binder.
Factor space for the development of sustainable energy technologies in construction
Authors: Myshovskaya Lyudmila , Mescheryakova Olga , Vlasenko Vyacheslav , Bukreev Anatoly
Published: August 2019

Sustainable development of construction and housing and utilities sector is impossible without ensuring energy efficiency and environmental friendliness of the production and operation of facilities. The authors consider it possible to ensure this through the implementation of a scientifically based innovation strategy of entities at all levels of the economy. The authors postulate the expediency of forming a strategy for the development of sustainable energy technologies based on foresight technology, taking into account the network nature of the interaction of participants and the need to coordinate micro and meso level strategies based on the creation of “innovation growth points”. To select the directions of strategic development of sustainable energy technologies and assess the effectiveness of their implementation, a list of analytical indicators of factors and results of the development is needed. Based on the adoption of the foresight methodology as a basis for building a strategy, and also based on the systems approach and the theory of self-organization of non-equilibrium systems, the need to develop a topology of indicators of the analytical unit as a basis for assessing the current state and heredity of the micro and meso level system has been proved. The authors proposed methodological provisions on the composition and structure of analytical indicators. On the basis of a statistical analysis of a number of indicators, the expediency of creating “innovation growth points” in the region in order to increase the efficiency of diffusion of innovative energy technologies in both intersectoral and interregional projections has been empirically proven.
The influence of sun-protective devices on natural Light distribution in premises
Authors: Stetsky Sergey , Larionova Kira
Published: August 2019

The article observes the new approach to a lighting environment in premises of civil buildings in hot and sunny climatic conditions. Under such conditions, the use of sun-protective devices (SPD) of different types and geometrics becomes traditional way of passive climate control in interiors. However, the authors determined, that the most traditional types of external SPD (such as canopies or awnings) have a different effect on indoor lighting environment due to the conditions of external natural illumination under overcast sky vault or clear sky conditions. In the first case, the stationary SPD act as shadowing elements, which block the light flows from the CIE standard overcast sky. In the second case, which corresponds to a clear sky sunny conditions, such SPD block the solar radiation, decreasing overheating and reflect sun beams to an interior, increasing the value of daylight factor (DF) at least in the furthest from windows areas of a premise. The proposed solutions allow reducing electric power consumption in buildings.
The method of iterative use of the ABC-XYZ analysis in the construction industry
Authors: Konikov Alexander
Published: August 2019

The issue of marketing in the construction industry has always remained relevant. Indeed, it is not easy to design objects so that they bring high and stable income. The paper studies a solution to the problem, based on the use of the iteration method, the ABC - XYZ analysis, and digital filtering. It is based on the well-known principle of the study of complex systems: the sequential division of a complex task into a number of simpler ones. We would like to note that the “classic” ABC - XYZ analysis gives only general results about the profits from construction projects and does not study the reasons due to which these profits are received. In contrast, the proposed tooling allows taking into account the main technical, geographical and other factors typical for profitable construction projects. One of the advantages of the considered approach is that the conventional computer tools - a spreadsheet MS Excel, is used in solution. The paper discusses the advantages and disadvantages of the proposed approach, specifies in which cases it is advisable to use this approach and where to use more powerful and expensive tools - Big Data technology. For better visualization and clarity, the elements of set theory are used in the paper. This methodology is universal, and its use in the energy industry is possible when selecting more profitable types of products.