bluuebunny/crossref_metadata_2025 huggingface dataset:
EDUCAÇÃO AMBIENTAL NAS EMPRESAS: UMA ANÁLISE A PARTIR DE AÇÕES SOCIOAMBIENTAIS NA EMPRESA MASTROTTO BRASIL
Authors: Barreto Carolina Borges da Silva , Santos Moacir Andrade dos
Published: April 2023

De acordo a Lei nº 9.795, de 27 de abril de 1999 que dispõe sobre a Política Nacional de Educação Ambiental no Art. 1º “Entendem-se por educação ambiental os processos por meio dos quais o indivíduo e a coletividade constroem valores sociais, conhecimentos, habilidades, atitudes e competências voltadas para a conservação do meio ambiente, bem de uso comum do povo, essencial à sadia qualidade de vida e sua sustentabilidade”. Dessa maneira a educação ambiental é essencial e deve está presente nos espaços de relações sociais, promovendo a educação ambiental em todos os níveis de ensino e conscientizando a sociedade sobre a conservação, recuperação e melhoria do meio ambiente. Conforme essa mesma Lei no Art. 3º, informa que cabe “às empresas[...] promover programas destinados à capacitação dos trabalhadores, visando à melhoria e controle efetivo sobre o ambiente de trabalho [...]”. O objetivo deste estudo é analisar as ações em educação ambiental na empresa Mastrotto Brasil, fundada no ano de 2000 no município de Cachoeira no Recôncavo Baiano, é altamente especializada no processamento do couro bovino para a indústria moveleira e automotiva, a empresa pertencente ao Grupo Mastrotto, uma multinacional Italiana presente no mercado desde 1958. No Brasil, atualmente emprega mais de 600 pessoas, tendo como objetivo e compromisso proporcionar aos colaboradores engajamento para que atuem de forma responsável e ambientalmente adequada, contribuindo para o desenvolvimento sustentável no âmbito das atividades realizadas no dia-dia do trabalho. A partir do edital de apoio a projetos socioambientais n° 01 do ano de 2020, elaborado pelo grupo Mastrotto, foi possível compreender o  comprometimento da empresa com Política de Qualidade Ambiental, reforçando a importância da educação ambiental e do engajamento com as comunidades circunvizinhas, compreendendo suas  responsabilidades perante o meio ambiente ao qual está inserida, tendo como objetivo a seleção de projetos voltados para o fomento da preservação e da proteção do Meio Ambiente local, o desenvolvimento sustentável, e a melhoria da qualidade de vida da população. Dessa maneira, a partir dessa breve análise foi possível compreender a importância da educação ambiental nas empresas, visto não apenas como forma de publicização, mas um meio eficiente de gerar impacto real nos colaboradores e na comunidade onde aquela empresa está presente.
HUKUM ISLAM DAN KOSMOLOGI
Authors: Muzawir Muzawir , Halid Wildan
Published: April 2023

Islam adalah agama yang membahas seluruh ajaran kehidupan dari level yang paling sederhana sampai level paling tinggi, mulai dari manusianya sendiri, kemudian bangsa jin, alam, serta angkasa, dari semua yang tercipta tidak ada yang sia-sia semua ada maksud dan tujuan. Seiring perkembangan yang terus terjadi hingga mengarah kepada spesialisasi keilmuan, yang menjadikan terpisah-pisah seiring munculnya dinamika dan paradigma keilmuan yang mencoba mengintegralisasikan keilmuan yakni mengambil jalan tengah dengan berpedoman pada AL-Qur’an sebagai referensi tertinggi,. Kosmologi sebagai cabang sains dari ilmu astronomi, menemukan titik nadir yaitu tidak adanya pemenuhan makna dalam tujuan kosmologi itu sendiri sehingga mencoba kembali membahas dengan memulai dari kitab Wahyu. Yang sebelumnya dimulai dengan kajian sains murni, filsafat murni, dan lainnya yang melepas diri dari wahyu itu sendiri. Pada awal perkembangan awal sebuah keilmuan para ilmuan mendewakan akal/rasionalitas, pun bukan berarti mencoba menghianati rasionalitas itu sendiri. Melalui teori integralistik keilmuan, ego-ego keilmuan mencoba untuk dilepaskan sehingga menemukan jatidiri keilmuan itu sendiri,. Dan tentu semua bisa, selama aktor intelektualnya tetap terbuka, kreatif, dan tidak kaku, baik dalam pengetahuan religius maupun saintifiknya.
Dairy Animal Production
Authors: Roy, Biswajit
Published: April 2023

This is a textbook on Dairy Plant Management and Dairy Waste Management which is a part of the course curriculum for the undergraduate and post graduate students of Dairy Technology.
Dairy Products and Quality Assurance: Vol.02: Dairy Technology
Authors: Singh Shivashraya
Published: April 2023

Commercial crops comprises of crops grown on a plantation scale and are of pivotal importance to the economy and export trade of many developing and developed countries. Commercial crops with long history of cultivation and active support of research and developmental efforts have made great strides in technological advancements. At regular intervals it is necessary to take stock of newly acquired knowledge in crop production and to reason out age-old experience. The book 'Commercial Crops Technology' comprehends the scattered information and provides latest technological advances in nine crops grown on a plantation scale. The book is organized into 10 s with an introductory and one each allotted to nine commercial crops (Areca Nut, Cashew, Cocoa, Coconut, Coffee, Oil palm, Palmyra, Rubber and Tea). s have been designed keeping view of the rapid progress and challenges in the field of sustainable crop production. Product diversification has also been given due importance in the light of globalization and free trade. The introductory gives an insight into the present scenario of plantation crop production, its importance, geographical distribution, soils growing, integrated nutrient management, crop protection strategies, cropping and farming systems, management of drought, organic farming, clean development mechanism, implications of IPR and strategies and recommendations. Individual s on crops covers uated information on crop improvement, biotechnology, crop production and management, crop protection and post harvest handling with emphasis on integrated nutrient and pest management, organic crop production and value addition, besides providing basic information on origin and distribution, production trends, botany and R and D institutions. Future outlook on these crops would enable to chalk out achievable programmes and projects. The bibliography facilitates further reading. This publication will be useful to everyone who are associated with commercial crops - farmers, estate managers, extension workers, technologists, policy makers, researchers and students.
Droughts in Agricultural Production: Monitoring & Management
Authors: Rao G.G.S.N.
Published: April 2023

Drought is considered to be a normal feature of climate especially in tropical countries where occurrence of periods of dry weather during rainy season is common. Virtually droughts can occur in all climates and they can also be witnessed when the air temperatures are higher than the normal for a longer period that increases both evaporation and water deficit. 1. The first deals with the introduction to the topic, historical evidences of drought and famines in India. 2. The definition of droughts, criteria for classification of droughts, drought indices based on rainfall, climate derivatives and remote sensing are covered under two. 3. Information on climate change with respects to climate trends, projections on temperature and rainfall at global as well at national level, consequences of climate change on droughts are presented in there. 4. Approaches on drought monitoring, adopted by various countries, international cooperation in drought monitoring and drought monitoring mechanism in India are presented in four. Decision Support Systems and applications of GIS for drought monitoring are also covered in this . 5. World food production and its variability, the impact of phenomenal drought during 2009 on food grain production in different countries, impacts of droughts on livestock, milk and fisheries production are covered under five. 6. Global surface waters, availability of surface waters in India, influence of drought on fauna and flora of surface waters and global warming on water resources at global and national level is discussed in – six. 7. Drought management strategies, drought planning and preparedness action plans at global as well at national level, indigenous knowledge on drought management, astrological techniques in weather forecasting and traditional wisdom on management of droughts in different nomadic communities in Asia and Africa are covered in seven. eight carries the conclusion of the entire book. Book will be useful to the students and research scholars of Agrometeorology, Meteorology and Geography and all Research Scientists dealing with NRM.
Drug Discovery and Development: Traditional Medicine and Ethnopharmacology
Authors: Patwardhan Bhushan
Published: April 2023

While biotechnological advances, genomics and high throughput screenings or combinatorial and asymmetric syntheses are opening new opportunities in drug discovery, the industry is facing serious innovation deficit.  The total number of new molecules registered per year has dropped in contrast to expected increase.  Post marketing failures of blockbuster drugs have become major concerns of industries.  On the other side, globally there is a major shift to sue of traditional medicine involving complementary and alternative therapies.  Ethnopharmacology and traditional medicines have contributed in past significantly in the process of natural product drug discovery.  There are two clear tracks where ethnopharmacology has potential to contribute in future drug research.  First, as a discovery engine to provide new targets, leads, and second, use of quality assured and standardized traditional medicines.  In this scenario, it is important to understand the mechanisms of drug discovery and pharmaceutical development with a focus on herbal drugs and neutraceutical.  This book provides historical perspective, future prospects and significance of ethnopharmacology in drug research.  It also provides important steps in botanical drug discovery and development including bioprospecting, quality control, standardization, pharmaceutics, stability, pharmacokinetics, and bioavailability with examples from ethnopharmacology and herbal medicine.  One of the important feature of this book is to give an excellent insight to Good Laboratory and Good Clinical Practices along with very useful summary steps involved in filing IND or NDA of botanical products.  The book also gives Regulators’ perspective of validating claims and how ethnopharmacological or traditional medicines need different approach.
Emerging Technologies of The 21St Century
Authors: Roy A.K.
Published: April 2023

Ex. Consultant (Statistics), College of Fisheries, Central Agricultural University, Lembucherra Tripura West, Ex. Computer Specialist, SAARC Agricultural Information Centre, Dhaka, Bangladesh, Ex Pr. Head, Social Science, CIFA, ICAR, Bhubaneswar, Ex Co-ordinator, Bioinformatics Centre, CIFA, ICAR, Bhubaneswar, All the 42 book s constitute the following focus areas like Biotechnology, Bioinformatics, Nanotechnology, Expert System Neural Network, Applied Technologies, Database, Modeling, Analytics and Business Intelligence Software, IPR & Social Issues. s on Emerging digital technologies, Information and communication Technology Tools, skill and technologies for 21st century Education, Big data, Business intelligence softwares, GIS, IPR and Knowledge/Patenting/Indigenous and Traditional Knowledge Management (KM) challenges are also included in the book. The book is divided into 5 broad sections covering the whole gamut of emerging technologies in the fields: 01.  Biotechnology, 02.  Nanotechnology, 03.  Expert System Neural Network, 04.  Applied Technologies, 05.  Database, Modeling, Analytics and Business Intelligence Software, It is expected that the book will be very much useful because with the emergence of new technologies and application through software tools are becoming very important in the 21st Century society.
Cytotoxic potential of a pigment from Serratia marcescens against HepG2 and Jurkat cell lines and optimization of culture conditions for enhanced pigment production
Authors: Megha Shukla  , Varalakshmi K. N
Published: April 2023

Background: Pigment from micro-organism is one of the emerging areas of research and many pigments have beenextensively studied for their therapeutic potential. Methodology: Our aim was to analyze the anticancer property of ared pigment extracted from Serratia marcescens JGI 27against HepG2 and Jurkat cell lines. The cell viability wasevaluated by MTT assay. As the red pigment extracted from S. marcescens exhibited high cytotoxicity to the testedcancer cell lines, the pigment production was optimized under various culture conditions like, temperature shock,incubation time, carbon sources, nitrogen sources and metal ions. Pigment yield was analyzed spectrophotometricallyat 487 nm. Results: The IC50 value of the red pigment was calculated around < 20μg/mL concentration. Thepercentage viability of lymphocytes and CHO was found to be negligible at all the selected concentration even after72 hrs of incubation. When the bacterial culture was kept at 37°C for 48 hrs and then 50°C for 48 hrs, the yield of thepigment was found to be highest. Supplimentation of sucrose (1%), beef extract (1%) and Fecl30. 01% resulted inenhanced pigment production from S. marcescens JGI 27. Supplementation with the metal ions with at concentrationresulted in highest pigment production. Conclusion: It is concluded that red pigment from S. marcescens JGI 27 wasfound to have a promising cyotoxic effect against HepG2 and Jurkat cell lines and it is non-toxic to normal peripheralhuman lymphocytes and CHO cell lines. At optimum physical and cultural parameters the pigment production wasfound to be highest.
Levels of serum magnesium in normal and diseased person -A comparative study
Authors: Mohammed Ghouseuddin  , Mir Wajahath Ali
Published: April 2023

The Magnesium is the fourth most abundant cation in the body, second most abundant cation of the intracellular fluidand is known to be intimately associated with a variety of metabolic events. The present study presents the data onlevel serum magnesium in normal and diseased persons (Renal Failure). The Results reveals that the mean serummagnesium levels are found to be higher in cases of Renal Failure in comparison with the control (normal) group,which may due to different pathological and malfunctioning of different systems
An Integrated Approach to Diagnosis and Therapy in Cancer
Authors: Saraswathi S  , Sushil Kumar Middha  , Jolitha B
Published: April 2023

Cancer is one of the major non-communicable diseases (NCD) worldwide, accounting for 22% deaths in 2012 worldwide. The number of cases is projected to increase to 17 million by 2020. According to ICMR, almost half of the cases will be in Asia with more than 17 lakh cases expected to occur in India by 2020. In such a scenario, early diagnosis and cost-effective treatment will play a major role in effective patient management. Developing the infrastructure required to cater to a vast population requires substantial effort in research and development. The National Symposium on “An Integrated Approach to Diagnosis and Therapy in Cancer” aims to create awareness about cancer etiology and stimulate the interest of students in cancer research. It has become unequivocally evident that tumor development depends on the intricate reciprocal interplay of tumor cells with their local and distant environments. Mutations in genes regulating cell cycle/cell proliferation can also contribute to tumorigenesis and is of great relevance in both diagnosis and disease management. One of the major focus of the symposia is developing diagnostics and therapeutics through translational research. The invited speakers will make presentations on emerging areas in cancer research like nanomedicine, personalized medicine, etc. Reputed clinicians and researchers will provide different perspectives on cancer biology. Thus, this symposium aims at a comprehensive functional understanding on the integrated role of physical and life sciences in diagnostics and therapeutics of cellular and molecular events that are responsible for the plasticity of tumor cells. Moreover, it will bring together experts in cancer and molecular biology who will share their expertise on a new generation of effective diagnostic tools and therapeutic approaches in cancer. One of the objectives of the symposium is to provide students and researchers with a platform for the exchange of knowledge and innovative ideas towards a comprehensive approach in cancer biology. It provides them with an ample opportunity to present their research work related to the conference theme.
Mapping the Resistance Potential of Influenza’s H + Channel Using an Anti
Authors: Pradeep S  , Midhun Manohar  , Nihal Kulkarni
Published: April 2023

One of the biggest problems faced by biotechnologists and pharmacologists all over the world is the difficulty in predicting the strains of viral diseases that are coming into circulation. The problem becomes much worse when it becomes difficult to predict the virus’s resistance pattern.Influenza A virus has many factors that play a role in its infection cycle. Here, we are trying to study how the virus exhibits resistance against an anti-viral blocker.The blocker that is used in this case is amino-adamantane antiviral inhibitor (adamantine).
Effect of controlled Nickel exposure on Duttaphrynus melanostictus oxidative stress and its management
Authors: P. Arya Alok  , Sushree Sangita Mohapatra  , Taslima Begum
Published: April 2023

This study mainly focuses on the effect of a common heavy metal poisoning and how the oxidative stress is managed in Duttaphrynus melanostictus during Nickel poisoning. The subject, Duttaphrynus melanostictus was exposed to Nickel in regular frequency with a very small amount by creating moist environment which imitates the presence of Nickel in soil due to pollution and then the body weight analysis (by ANOVA and Post Hoc analysis (using SPSS package 16.0)) and skin coloration and pigmentation were checked at 24 hours interval to study the oxidative stress and its management by the animal's physiological system. The initial change in skin color at early stages of nickel exposure and then its restoration was observed. Similarly the loss of body weight at initial exposure and then its stabilization after some days was noted. The analysis and observations revealed that the antioxidant system of Duttaphrynus melanostictus is well developed to sustain against the oxidative stress due to nickel exposure.
Pensar en calidad desde el Trabajo Social: opiniones y propuestas
Authors: Ochando Ramírez Mª Victoria , Morcillo Martínez Juana María
Published: April 2023

El Trabajo Social contribuye a la calidad de vida de las personas, grupos y comunidades y a la calidad del servicio.
El objetivo es explorar las opiniones sobre calidad desde el Trabajo Social. Se estudian aspectos destacados de la profesión y sobre calidad.
Metodología . Se ha realizado una investigación exploratoria a 210 participantes con el perfil de Trabajo Social: profesionales, docentes universitarios y alumnado de Grado de todos los cursos de Universidades públicas y privadas españolas. Se ha optado por una investigación mixta, predominando el enfoque cualitativo. Posteriormente, se ha analizado el discurso con Maxqda, estableciendo categorías. Finalmente, se ha podido describir aspectos de la profesión, definir calidad desde el Trabajo Social, e identificar algunos atributos que reportan calidad al ejercicio profesional. El Trabajo Social es una profesión comprometida y con grandes desafíos, los cuales pueden ser vistos como una oportunidad para lograr la transformación que la profesión y la sociedad demanda.  La calidad puede establecerse como una herramienta indispensable para el quehacer del Trabajo Social.
Comité de mujeres como red social para generar participación comunitaria: experiencia en Culiacán, Sinaloa México
Authors: Verdugo Araujo Luz Mercedes , Tereso Rodríguez Leonor , Carrillo Montoya Teresita del Niño Jesús
Published: April 2023

El objetivo de este artículo es analizar las motivaciones individuales-colectivas para la conformación de un comité de mujeres y cómo este se convierte en una red social para generar mecanismos de participación comunitaria en una colonia de la ciudad de Culiacán, Sinaloa, México. Desde un enfoque cualitativo y a través del método fenomenológico, se recuperó la experiencia de siete mujeres que integran el comité comunitario, a las cuales se les aplicó una entrevista semiestructurada. La información recuperada se sistematizó para un análisis conversacional en el que se recuperaron las principales categorías como proceso de conformación del comité comunitario, procesos de interacción, socialización, colaboración y generación de mecanismos de participación comunitaria. Los resultados demuestran que las mujeres interactúan con redes institucionales, establecen mecanismos de colaboración mutua y socializan a través del dialogo generando transformaciones individuales para sus miembros pero también en la comunidad teniendo efectos positivos en la calidad de vida colectiva, afianzando el sentido comunitario y concretando mecanismos de participación comunitaria.
Three-dimensional Au(NiMo)/Ti catalysts for efficient oxygen evolution reaction
Authors: Barua Sukomol , Balčiūnaitė Aldona , Vaičiūnienė Jūratė , Tamašauskaitė-Tamašiūnaitė Loreta , Norkus Eugenijus
Published: April 2023

In this study, three-dimensional gold-nickel-molybdenum (Au(NiMo)) catalysts have been studied as catalysts for the oxygen evolution reaction (OER). The catalysts have been deposited on a titanium surface using electroplating and galvanic displacement techniques. The modification of NiMo with a low amount of Au crystallites in a range of 1.2– 5.2 μgAucm–2 results in enhanced activity for OER in the alkaline medium compared to respective binary un-modified NiMo catalysts. The current densities for OER increase ca.1.2–7.3 and 1.3–5.1 times with an increase in temperature from 25 up to 75°C using the prepared 3D binary NiMo/ Ti and Au(NiMo)/Ti catalysts, respectively.
LLÚCIA MARTÍN PASCUAL, Bestiari medieval, Barcelona, Barcino, 2022, 250 pp. [ISBN 978-84-7226-905-7]
Authors: Redondo Jordi
Published: April 2023

LLÚCIA MARTÍN PASCUAL, Bestiari medieval, Barcelona, Barcino, 2022, 250 pp. [ISBN 978-84-7226-905-7]
Algunas notas en torno al uso del anapesto lírico en tres comedias de Aristófanes
Authors: Egea Sánchez Joan
Published: April 2023

En este trabajo realizaremos un análisis de una serie de casos en los que Aristófanes utiliza el metro anapéstico lírico para dotar de ciertas connotaciones paródicas a algunas de sus escenas. Para ello, nos centraremos en primer lugar en unas escenas de tragedia en las que el uso del anapesto es indicativo de una situación terrible o de una acentuación de las emociones del personaje; después, analizaremos determinadas escenas ubicadas en tres comedias, Lisístrata, Las Tesmoforiantes y Las Ranas, en las que el uso de este metro de connotaciones elevadas y propio de la alta poesía se inserta en una situación totalmente absurda. De este modo, intentaremos mostrar que Aristófanes conoce bien este uso del anapesto que hacen los trágicos y que, como maestro del lenguaje en todas sus vertientes, sabe ponerlo al servicio de la comedia.
Interplay between external inputs and recurrent dynamics during movement preparation and execution in a network model of motor cortex
Authors: Bachschmid-Romano Ludovica , Hatsopoulos Nicholas G , Brunel Nicolas
Published: April 2023

The primary motor cortex has been shown to coordinate movement preparation and execution through computations in approximately orthogonal subspaces. The underlying network mechanisms, and the roles played by external and recurrent connectivity, are central open questions that need to be answered to understand the neural substrates of motor control. We develop a recurrent neural network model that recapitulates the temporal evolution of neuronal activity recorded from the primary motor cortex of a macaque monkey during an instructed delayed-reach task. In particular, it reproduces the observed dynamic patterns of covariation between neural activity and the direction of motion. We explore the hypothesis that the observed dynamics emerges from a synaptic connectivity structure that depends on the preferred directions of neurons in both preparatory and movement-related epochs, and we constrain the strength of both synaptic connectivity and external input parameters from data. While the model can reproduce neural activity for multiple combinations of the feedforward and recurrent connections, the solution that requires minimum external inputs is one where the observed patterns of covariance are shaped by external inputs during movement preparation, while they are dominated by strong direction-specific recurrent connectivity during movement execution. Our model also demonstrates that the way in which single-neuron tuning properties change over time can explain the level of orthogonality of preparatory and movement-related subspaces.
Single-cell transcriptomic atlas of lung microvascular regeneration after targeted endothelial cell ablation
Authors: Godoy Rafael Soares , Cober Nicholas D , Cook David P , McCourt Emma , Deng Yupu , Wang Liyuan , Schlosser Kenny , Rowe Katelynn , Stewart Duncan J
Published: April 2023

We sought to define the mechanism underlying lung microvascular regeneration in a model of severe acute lung injury (ALI) induced by selective lung endothelial cell ablation. Intratracheal instillation of DT in transgenic mice expressing human diphtheria toxin (DT) receptor targeted to ECs resulted in ablation of >70% of lung ECs, producing severe ALI with near complete resolution by 7 days. Using single-cell RNA sequencing, eight distinct endothelial clusters were resolved, including alveolar aerocytes (aCap) ECs expressing apelin at baseline and general capillary (gCap) ECs expressing the apelin receptor. At 3 days post-injury, a novel gCap EC population emerged characterized by de novo expression of apelin, together with the stem cell marker, protein C receptor. These stem-like cells transitioned at 5 days to proliferative endothelial progenitor-like cells, expressing apelin receptor together with the pro-proliferative transcription factor, Foxm1, and were responsible for the rapid replenishment of all depleted EC populations by 7 days post-injury. Treatment with an apelin receptor antagonist prevented ALI resolution and resulted in excessive mortality, consistent with a central role for apelin signaling in EC regeneration and microvascular repair. The lung has a remarkable capacity for microvasculature EC regeneration which is orchestrated by newly emergent apelin-expressing gCap endothelial stem-like cells that give rise to highly proliferative, apelin receptor-positive endothelial progenitors responsible for the regeneration of the lung microvasculature.
Interactions between metabolism and growth can determine the co-existence of Staphylococcus aureus and Pseudomonas aeruginosa
Authors: Pajon Camryn , Fortoul Marla C , Diaz-Tang Gabriela , Marin Meneses Estefania , Kalifa Ariane R , Sevy Elinor , Mariah Taniya , Toscan Brandon , Marcelin Maili , Hernandez Daniella M , Marzouk Melissa M , Lopatkin Allison J , Eldakar Omar Tonsi , Smith Robert P
Published: April 2023

Most bacteria exist and interact within polymicrobial communities. These interactions produce unique compounds, increase virulence and augment antibiotic resistance. One community associated with negative healthcare outcomes consists of Pseudomonas aeruginosa and Staphylococcus aureus. When co-cultured, virulence factors secreted by P. aeruginosa reduce metabolism and growth in S. aureus. When grown in vitro, this allows P. aeruginosa to drive S. aureus toward extinction. However, when found in vivo, both species can co-exist. Previous work has noted that this may be due to altered gene expression or mutations. However, little is known about how the growth environment could influence the co-existence of both species. Using a combination of mathematical modeling and experimentation, we show that changes to bacterial growth and metabolism caused by differences in the growth environment can determine the final population composition. We found that changing the carbon source in growth media affects the ratio of ATP to growth rate for both species, a metric we call absolute growth. We found that as a growth environment increases the absolute growth for one species, that species will increasingly dominate the co-culture. This is due to interactions between growth, metabolism, and metabolism-altering virulence factors produced by P. aeruginosa. Finally, we show that the relationship between absolute growth and the final population composition can be perturbed by altering the spatial structure in the community. Our results demonstrate that differences in growth environment can account for conflicting observations regarding the co-existence of these bacterial species in the literature, provides support for the intermediate disturbance hypothesis, and may offer a novel mechanism to manipulate polymicrobial populations.
Regulation of different phases of AMPA receptor intracellular transport by 4.1N and SAP97
Authors: Bonnet Caroline , Charpentier Justine , Retailleau Natacha , Choquet Daniel , Coussen Françoise
Published: April 2023

Changes in the number of synaptic AMPA receptors underlie many forms of synaptic plasticity. These variations are controlled by an interplay between their intracellular transport (IT), export to the plasma membrane (PM), stabilization at synapses, and recycling. The cytosolic C-terminal domain of the AMPAR GluA1 subunit is specifically associated with 4.1 N and SAP97. We analyze how interactions between GluA1 and 4.1N or SAP97 regulate IT and exocytosis in basal conditions and after cLTP induction. The down-regulation of 4.1N or SAP97 decreases GluA1 IT properties and export to the PM. The total deletion of its C-terminal fully suppresses its IT. Our results demonstrate that during basal transmission, the binding of 4.1N to GluA1 allows their exocytosis whereas the interaction with SAP97 is essential for GluA1 IT. During cLTP, the interaction of 4.1N with GluA1 allows its IT and exocytosis. Our results identify the differential roles of 4.1N and SAP97 in the control of various phases of GluA1 IT.
On parsimony and clustering
Authors: Oggier Frédérique , Datta Anwitaman
Published: April 2023

This work is motivated by applications of parsimonious cladograms for the purpose of analyzing non-biological data. Parsimonious cladograms were introduced as a means to help understanding the tree of life, and are now used in fields related to biological sciences at large, e.g., to analyze viruses or to predict the structure of proteins. We revisit parsimonious cladograms through the lens of clustering and compare cladograms optimized for parsimony with dendograms obtained from single linkage hierarchical clustering. We show that despite similarities in both approaches, there exist datasets whose clustering dendogram is incompatible with parsimony optimization. Furthermore, we provide numerical examples to compare via F-scores the clustering obtained through both parsimonious cladograms and single linkage hierarchical dendograms.
A retrospective investigation of spatial clusters and determinants of diabetes prevalence: scan statistics and geographically weighted regression modeling approaches
Authors: Lord Jennifer , Roberson Shamarial , Odoi Agricola
Published: April 2023

Background

Diabetes and its complications represent a significant public health burden in the United States. Some communities have disproportionately high risks of the disease. Identification of these disparities is critical for guiding policy and control efforts to reduce/eliminate the inequities and improve population health. Thus, the objectives of this study were to investigate geographic high-prevalence clusters, temporal changes, and predictors of diabetes prevalence in Florida.

Methods

Behavioral Risk Factor Surveillance System data for 2013 and 2016 were provided by the Florida Department of Health. Tests for equality of proportions were used to identify counties with significant changes in the prevalence of diabetes between 2013 and 2016. The Simes method was used to adjust for multiple comparisons. Significant spatial clusters of counties with high diabetes prevalence were identified using Tango’s flexible spatial scan statistic. A global multivariable regression model was fit to identify predictors of diabetes prevalence. A geographically weighted regression model was fit to assess for spatial non-stationarity of the regression coefficients and fit a local model.

Results

There was a small but significant increase in the prevalence of diabetes in Florida (10.1% in 2013 to 10.4% in 2016), and statistically significant increases in prevalence occurred in 61% (41/67) of counties in the state. Significant, high-prevalence clusters of diabetes were identified. Counties with a high burden of the condition tended to have high proportions of the population that were non-Hispanic Black, had limited access to healthy foods, were unemployed, physically inactive, and had arthritis. Significant non-stationarity of regression coefficients was observed for the following variables: proportion of the population physically inactive, proportion with limited access to healthy foods, proportion unemployed, and proportion with arthritis. However, density of fitness and recreational facilities had a confounding effect on the association between diabetes prevalence and levels of unemployment, physical inactivity, and arthritis. Inclusion of this variable decreased the strength of these relationships in the global model, and reduced the number of counties with statistically significant associations in the local model.

Conclusions

The persistent geographic disparities of diabetes prevalence and temporal increases identified in this study are concerning. There is evidence that the impacts of the determinants on diabetes risk vary by geographical location. This implies that a one-size-fits-all approach to disease control/prevention would be inadequate to curb the problem. Therefore, health programs will need to use evidence-based approaches to guide health programs and resource allocation to reduce disparities and improve population health.
Application of the Threat Modeling Method In an Operating System
Authors: Yokoyama Rodrigo , Arima Carlos Hideo
Published: April 2023

Due to the increase in professionals adopting the home office model due to the COVID-19 pandemic, the threat to company information and assets has become more evident. This work aims to identify, describe and evaluate the impacts of applying the threat modeling method, using risk management standards, on corporate computers with the aid of a monitoring system. The proposed method for application suggests the adoption of processes and a system for updating, controlling and managing the Windows Operating System to reduce the threats faced. The research identified security using the STRIDE and DREAD methods and the ISO and NIST security standards. It verified 14 types of threats found in an operating system that can be properly identified and mitigated with the threat exploitation method.
Persistências e rupturas no estudo do Coronavírus após a epidemia da COVID-19
Authors: Naziazeno Ronaldo , Martins Cláudia de Souza Ferreira , Guedes Cristina , Pinheiro Marcelo Santana , De Cristo Hélio Souza , Alves Lynn Rosalina Gama , Nascimento Filho Aloisio Santos , Saba Hugo
Published: April 2023

O presente artigo, partindo do conjunto de palavras-chave de mais de 500 artigos relacionados à família do coronavírus, com publicações ao longo de 20 anos (2002 – 2022) e a formação de redes semânticas, analisa tais redes em sua topologia e características, assim como o conjunto de análises sobre as centralidades de nós, com o objetivo de vislumbrar uma métrica que apontasse temas e autores que colaboraram no estudo dos coronavírus antes da pandemia, aqueles que vieram antes da pandemia, mas tiveram contribuição relevante ao longo da pandemia nos anos estudados e aqueles que se somaram nos pós start da pandemia. No geral, busca-se analisar as persistências e rupturas da comunidade acadêmica frente ao novo Sars-Cov-2.  Tal método se justifica como uma rota rápida e eficaz para filtrar bases teóricas e experimentais, pessoas e conhecimentos frente a um novo desafio, tal qual uma pandemia. Em linhas gerais, admite-se, neste trabalho, que palavras-chave são descritores importantes dos artigos publicados e, assim sendo, também cumprem um papel relevante como indicadores da agenda de pesquisa da comunidade de ciência. Percebe-se que as redes semânticas formadas por palavras-chave dos artigos selecionados mostraram aqui uma topologia com fortes características de uma rede mundo pequeno, o que evidencia uma forte ligação entre uma palavra-chave qualquer e sua vizinhança.
Propaganda e Marketing em empresas, bibliotecas escolares e bibliotecas institucionais: a subestimação e subutilização do marketing, marketing digital e do neuromarketing em bibliotecas
Authors: De Lima Alan Freire , De Lima Arlete Freire , Fofonca Eduardo , Lopes Gabriel Cesar Dias
Published: April 2023

Objetivo: O objetivo deste trabalho teve apresentar conceitos de administração de marketing, marketing digital e marketing em unidades de informação, também chamadas de bibliotecas aplicadas em empresas, instituições e bibliotecas. Neste estudo focamos nos serviços e produtos oferecidos pelo Sistema Municipal de Bibliotecas de São Paulo, especialmente nas informações disponibilizadas publicamente em seu site institucional. Metodologia: A metodologia utilizada foi a revisão de literatura ou bibliográfica nas áreas de administração de marketing, propaganda, marketing, marketing digital e marketing em bibliotecas. Originalidade: A importância da propaganda e do marketing para a divulgação dos serviços e produtos de unidades de informações como bibliotecas públicas, bibliotecas escolares, bibliotecas universitárias e especializadas, dentre outras, já é conhecida, porém pouco estudada e potencializada na prática profissional dos cientistas da informação e bibliotecários. Resultados: Os resultados são otimistas do ponto de vista teórico da área de marketing e marketing para bibliotecas, entretanto observamos que o website redes sociais digitais do Sistema Municipal de Bibliotecas de São Paulo (SMB), são subestimados e subutilizados, provavelmente devido a má qualificação acadêmica destes profissionais. Contribuição teórica e prática: As contribuições teóricas e técnicas das ciências da administração de marketing, gestão de marketing, marketing digital para unidades de informação como as bibliotecas são de suma importância, pois há a carência das disciplinas de marketing para bibliotecas e unidades de informação e bibliotecas escolares nos cursos de formação dos cientistas da informação, mais comumente conhecidos como bibliotecários, que repercute no esta da arte exposto neste trabalho.
Accuracy of Ultrasound Imaging Findings in Diagnosis of Adnexal Masses: A Cross-sectional Study
Authors: Gambhir Harish , Aditya Kewal , Singh Ravinder Pal , Singla Subhash , Issacs Roma , Goyal Sunita
Published: April 2023

Introduction: Adnexal mass lesions are common among women of all age groups. Precise preoperative estimation of the benign or malignant nature of an adnexal mass is important to avoid additional surgical treatment. Sonography is the initial imaging study of choice in the evaluation of women with suspected adnexal masses. Assiut scoring model is a simpler model for differentiation of adnexal masses into benign and malignant using various ultrasonographic parameters. Aim: To assess the accuracy of ultrasound in differentiating benign from malignant adnexal masses using Assiut scoring model. Materials and Methods: This cross-sectional study was conducted in Department of Radiodiagnosis at Christian Medical College and hospital (tertiary care hospital), Ludhiana, Punjab, India, from November 2018 to January 2021. The study included 80 cases of adnexal masses. An Ultrasound (USG) diagnosis was made based on tumour volume, type of mass, papillary projections, septae and vessel location and Assiut score was obtained. Histopathological examination was carried out following surgery or biopsy. The diagnostic accuracy of USG (with histopathology as gold standard) was determined. Sensitivity, specificity, positive predictive value and negative predictive value of USG was assessed for predicting malignancy taking histopathology as gold standard. The p-value <0.05 was considered statistically significant. Results: Most numbers of patients (33 patients, 41.25%) belonged to age group 21-30 years. Mean age of study subjects was 35.35±12.8 years. Majority (60, 75%) of patients were benign and 20 (25%) were malignant. The USG findings showed good agreement with histopathology (kappa=0.76, p-value<0.0001). Sensitivity, specificity, Positive Predictive Value (PPV) and Negative Predictive Value (NPV) for correctly predicting malignant lesions being 90%, 90%, 75% and 96.43% respectively. Median Assiut score in malignant was significantly higher as compared to benign (9.95 vs 3.47, p-value<0.0001). Characteristics such as central or septal vascularization, presence of thick septa, papillary projections, multilocularity and high tumour volume (especially above 500 mL) showed a significant association with malignancy (p-value<0.0001). Conclusion: The USG based Assuit scoring model is a good tool in differentiating benign from malignant adnexal masses with high sensitivity and specificity.
Detection of Locations of Pancreatic Pseudocysts using Computed Tomography: A Retrospective Study
Authors: Fernandes Vanessa , Braggs Anston Vernon
Published: April 2023

Introduction: The most common cystic lesion of the pancreas are pseudocysts of the pancreas. They are frequently observed in the peripancreatic regions, however, they may appear elsewhere. Knowledge of their varied locations becomes crucial for estimating their size and organising surgical treatments with respect to their mode of drainage and also knowing the exact surgical planes. Aim: To determine the distribution of pancreatic pseudocysts using a computed tomography ( CT) scan. Materials and Methods: This was a retrospective observational time-bound carried out from December 2018 to December 2020 in Department of Radiology, Father Muller Medical College Hospital, Mangaluru, Karnataka, India. After obtaining ethical clearance, 56 patients with pancreatic pseudocyst diagnosed on ultrasound and later evaluated by CT were included. The protocol used was 128-slice Multidetector Computed Tomography (MDCT), plain and contrast axial images with multiplanar reformations. The primary outcome was to study the various locations in which these pseudocysts were present. The data was entered in a Microsoft Excel sheet. The frequency distribution of data was calculated. Results: Out of the 56 patients, 42 (75%) were males and 14 (25%) were females. Incidence of pseudocyst formation was highest in the age group 40-50 years 23, (41.07%). The most common location of pancreatic pseudocyst was the lesser sac 19 (33.92%). Other sites included peritoneum (n=7, 12.5%%), hepatic (n=8, 14.2%) and sub-hepatic (n=3, 5.36%), perinephric (n=5 , 8.92%), Intrasplenic and perisplenic (n=5, 8.92%), gastric (n=3, 5.36%), subdiaphragmatic regions (n=2, 3.57%), in the Psoas major (n=2, 3.57%) and mediastinum (n=2, 3.57%). Conclusion: The present study concludes that the most common location of a pancreatic pseudocyst is the lesser sac.
Impact of Social Media on Eating Disorders in Adolescents and Emerging Therapies: A Review
Authors: Dhoke Rohit , Suraj Shaini , Singh Brij Raj , Bankar Nandkishor
Published: April 2023

The saying goes ‘You are what you eat’. This is in reference to a healthy and balanced diet which gives a boost to one’s mental and physical health. But in recent times, Eating Disorders (ED) are seen to increase among adolescents. These result from several factors, including prevalence of unhealthy dieting behaviours and unrealistic beauty images. Advertising has popularised a thin body ideal. Social media is influencing the young minds in their food choices. Constant use of pictures, advertisements, videos by celebrities and other social media influencers have caused an increase in body dissatisfaction especially among adolescents. The ideal body portrayed by media for women is a very thin body, perfect in shape, and for men it is a muscular and tall body image. The adolescent brain has increased levels of ‘neuroplasticity’ and hence is malleable that is it is highly responsive to being shaped and re-wired by the environment- which also includes diet and body images. Hence, the need of the hour is to set in place healthy dietary habits and exercise routine along with will power for lifelong healthy living.
A Survey to Assess Awareness and Knowledge on the Role of Artificial Intelligence (AI) in Dentistry among Dental Teaching Faculty from Various Dental Colleges across India
Authors: Rao B. Lakshmana , ChandraSekhar G. , Reddy Ragipindi N. R. Raviteja , Karthik P. , Shivakiran Y. , Nalla Sandeep
Published: April 2023

Aim: The aim of present study was intended to assess the dental teaching faculty of various dental colleges across India were how much aware and know about the role of Artificial Intelligence (AI)in Dentistry.

Study Design: A descriptive cross-sectional study was performed using a pre-designed questionnaire through various social media.

Place and Duration of Study: Through e-mails, and Whats App, the Questionnaire was sent to the participants of various dental colleges across India from 6th February 2023 to 31st March 2023.

Methodology: Validated and pre-tested questionnaire was used and sent to dental teaching faculty of various dental institutions across India. A total of 407 responses were received. The received data was entered in Microsoft Excel sheet. Descriptive Statistical Analysis was done by using IBM SPSS version 26.

Results: A total of 407 faculty members participated. Associate Professors/Readers stood in first place (149) and the least participation from Assistant Professors/Senior Lecturers (43). Gender wise males are dominated (217) than females (190). 42.4% of Professors were aware about the applications of AI already using in Dentistry and 93.9% of the participants of the opinion that in the future, AI is threat for the dentists.

Conclusion: Almost all the participants expressed their opinion on AI based treatment which will be accepted by the patients and all the teaching faculty members knows about the latest advances of AI in dentistry.