bluuebunny/crossref_metadata_2025 huggingface dataset:
Valuing embodiment: insights from dance practice among people living with dementia
Authors: Kaczmarska Magda
Published: June 2023

There is a growing appreciation for the ability of person-centered arts-based approaches to extend multiple domains of brain health of people living with dementia. Dance is a multi-modal artistic engagement which has positive impacts on cognition, mobility and the emotional and social aspects of brain health. Although research into multiple domains of brain health among older adults and people living with dementia is promising, several gaps remain, specifically in understanding the benefits of co-creative and improvisational dance practices. Collaborative research between dancers, researchers, people living with dementia and care partners is needed to design and evaluate future research on dance and to determine relevance and usability. Furthermore, the respective praxes and experience of researchers, dance artists and people living with dementia contribute distinctly and uniquely to the identification and the assignment of value to dance in the context of the lives of people living with dementia. In this manuscript the author, a community-based dance artist, creative aging advocate and Atlantic Fellow for Equity in Brain Health, discusses current challenges and gaps in the understanding of the value of dance for and with people living with dementia and how transdisciplinary collaboration between neuroscientists, dance artists and people living with dementia can advance collective comprehension and implementation of dance practice.
Burden of dilated perivascular spaces in patients with moyamoya disease and moyamoya syndrome is related to middle cerebral artery stenosis
Authors: Han Guangsong , Fan Xiaoyuan , Hong Yuehui , Zhou Lixin , Zhu Yicheng , Feng Feng , Yao Ming , Ni Jun
Published: June 2023

Background and objective

The correlation between intracranial large artery disease and cerebral small vessel disease (CSVD) has become a noteworthy issue. Dilated perivascular spaces (dPVS) are an important marker of CSVD, of which cerebral atrophy has been regarded as one of the pathological mechanisms. DPVS has been found to be associated with vascular stenosis in patients with moyamoya disease (MMD), but the underlying mechanism remains unclear. The purpose of our study was to explore the correlation between the middle cerebral artery (MCA) stenosis and dPVS in the centrum semiovale (CSO-dPVS) in patients with MMD/moyamoya syndrome (MMS) and to determine whether brain atrophy plays a mediating role in this relationship.

Methods

A total of 177 patients were enrolled in a single-center MMD/MMS cohort. Images of their 354 cerebral hemispheres were divided into three groups according to dPVS burden: mild (dPVS 0–10), moderate (dPVS 11–20), and severe (dPVS > 20). The correlations among cerebral hemisphere volume, MCA stenosis, and CSO-dPVS were analyzed, adjusting for the confounding factors of age, gender, and hypertension.

Results

After adjustment for age, gender, and hypertension, the degree of MCA stenosis was independently and positively associated with ipsilateral CSO-dPVS burden (standardized coefficient: β = 0.247, P < 0.001). A stratified analysis found that the subgroup with a severe CSO-dPVS burden exhibited a significantly higher risk of severe stenosis of the MCA [p < 0.001, OR = 6.258, 95% CI (2.347, 16.685)]. No significant correlation between CSO-dPVS and ipsilateral hemisphere volume was found (p = 0.055).

Conclusion

In our MMD/MMS cohort, there was a clear correlation between MCA stenosis and CSO-dPVS burden, which may be a direct effect of large vessel stenosis, without a mediating role of brain atrophy.
A luminescence-based reporter to study tau secretion reveals overlapping mechanisms for the release of healthy and pathological tau
Authors: Lopez Dianne Marquez , Maltby Connor J. , Warming Hannah , Divecha Nullin , Vargas-Caballero Mariana , Coldwell Mark J. , Deinhardt Katrin
Published: June 2023

In Alzheimer’s disease, tau pathology is thought to spread via a prion-like manner along connected neuronal networks. For this to occur, the usually cytosolic tau protein must be secreted via an unconventional mechanism prior to uptake into the connected neuron. While secretion of healthy and pathological tau has been documented, it remains under-investigated whether this occurs via overlapping or distinct processes. Here, we established a sensitive bioluminescence-based assay to assess mechanisms underlying the secretion of pseudohyperphosphorylated and wild-type tau in cultured murine hippocampal neurons. We found that under basal conditions, both wild-type and mutant tau are secreted, with mutant tau being more robustly secreted. Pharmacological stimulation of neuronal activity led to a modest increase of wild-type and mutant tau secretion, whereas inhibition of activity had no effect. Interestingly, inhibition of heparin sulfate proteoglycan (HSPG) biosynthesis drastically decreased secretion of both wild-type and mutant tau without affecting cell viability. This shows that native and pathological tau share release mechanisms; both activity-dependent and non-activity-dependent secretion of tau is facilitated by HSPGs.
Bioactivity and nutritional quality of nutgall (Rhus semialata Murray), an underutilized fruit of Manipur
Authors: Singh Thangjam Surchandra , Kshetri Pintubala , Devi Asem Kajal , Langamba Pangambam , Tamreihao Keishing , Singh Heikham Naresh , Akoijam Romila , Chongtham Tania , Devi Chingakham Premabati , Singh Tensubam Basanta , Chongtham Sonia , Devi Yumnam Prabhabati , Kuna Aparna , Singh Soibam Giri , Sharma Susheel Kumar , Das Anup , Roy Subhra Saikat
Published: June 2023

Introduction

Underutilized fruits plays a significant role in socio economic, cultural, nutritional and ethnomedicinal status of tribal people. However, scientific studies on the nutritional and other pharmaceuticals/biological activities of these fruits are meagre. Hence, the present study dealt with the quantification of nutritional quality and deciphering the bioactivity of nutgall (Rhus semialata Murray syn. Rhus chinensis Mill.), an underutilized fruit crop mainly found in foothill tracks of Eastern Himalaya, India, China, Japan, Korea and other South East Asian countries.

Methods

The Rhus semialata Murray fruits were collected from five different locations in Purul sub-division, Senapati district, Manipur, India. The nutritional composition of the fruit pulp was analysed. Further the fruit pulp was extracted in methanol and water. The methanol and water extracts were studied for bioactivity properties such as antioxidant, antihyperglycemic, antihypertensive, antihyperuricemia, anti-tyrosinase, and antimicrobial activity.

Results and discussion

The fruit was rich in essential fatty acids. The presence of linoleic and oleic acids, along with traces of docosahexaenoic acid and eicosapantaenoic acid, revealed the potential food value of the fruit. 59.18% of the total amino acid composition of the protein present was constituted by essential amino acids. The IC50 value of methanolic extract (MExt) and Water extract (WExt) of the fruit were recorded as 4.05 ± 0.22 and 4.45 ± 0.16 μg/mL, respectively, in the DPPH assay and 5.43 ± 0.37 and 11.36 ± 2.9 μg/mL, respectively, in the ABTS assay as compared to Ascorbic acid (3 and 5.4 μg/mL in DPPH and ABTS assay, respectively). The CUPRAC assay also showed a high antioxidant potential of MExt and WExt (1143.84 ± 88.34 and 456.53 ± 30.02 mg Ascorbic Acid Equivalent/g, respectively). MExt and WExt of the fruit were more active against α-glucosidase (IC50 of 1.61 ± 0.34 and 7.74 ± 0.54 μg/ mL, respectively) than α-amylase enzyme (IC50 14.15 ± 0.57 and 123.33 ± 14.7 μg/mL, respectively). In addition, the methanolic fruit extract showed low to moderate pharmacological potential in terms of antihypertensive (Angiotensin converting enzyme-I inhibition), antihyperuricemia (xanthine oxidase inhibition), anti-tyrosinase, and antimicrobial activity. The IC50 values of angiotensin-converting enzyme I inhibition, xanthine oxidase inhibition and tyrosinase inhibition were recorded as 13.35 ± 1.21 mg/mL, 93.16 ± 4.65 mg/mL, and 862.7 ± 12.62 μg/mL, respectively. The study evidently indicates that nutgall fruit is a potential source of phytonutrients, bestowed with commercially exploitable, multifaceted health benefits
Pediatric autoinflammatory bone disorders—a mini review with special focus on pathogenesis and inborn errors of immunity
Authors: Hetrick Rebecca , Oliver Melissa
Published: June 2023

Autoinflammatory bone disorders are a group of diseases characterized by sterile osteomyelitis. This includes chronic nonbacterial osteomyelitis and the monogenic forms, Majeed syndrome and deficiency of the interleukin-1 receptor antagonist. These disorders result from innate immune system dysregulation and cytokine imbalance that triggers inflammasome activation causing downstream osteoclastogenesis and excessive bone remodeling. In this review, we will summarize the immunopathogenesis of pediatric autoinflammatory bone diseases with a special focus on the genetics and inborn errors of immunity, while briefly touching on the clinical manifestations and management of each disease as well as areas for future research.
Nitrate reductase is required for sclerotial development and virulence of Sclerotinia sclerotiorum
Authors: Wei Junjun , Yao Chuanchun , Zhu Zonghe , Gao Zhimou , Yang Guogen , Pan Yuemin
Published: June 2023

Sclerotinia sclerotiorum, the causal agent of Sclerotinia stem rot (SSR) on more than 450 plant species, is a notorious fungal pathogen. Nitrate reductase (NR) is required for nitrate assimilation that mediates the reduction of nitrate to nitrite and is the major enzymatic source for NO production in fungi. To explore the possible effects of nitrate reductase SsNR on the development, stress response, and virulence of S. sclerotiorum, RNA interference (RNAi) of SsNR was performed. The results showed that SsNR-silenced mutants showed abnormity in mycelia growth, sclerotia formation, infection cushion formation, reduced virulence on rapeseed and soybean with decreased oxalic acid production. Furthermore SsNR-silenced mutants are more sensitive to abiotic stresses such as Congo Red, SDS, H2O2, and NaCl. Importantly, the expression levels of pathogenicity-related genes SsGgt1, SsSac1, and SsSmk3 are down-regulated in SsNR-silenced mutants, while SsCyp is up-regulated. In summary, phenotypic changes in the gene silenced mutants indicate that SsNR plays important roles in the mycelia growth, sclerotia development, stress response and fungal virulence of S. sclerotiorum.
Responses of two Acacia species to drought suggest different water-use strategies, reflecting their topographic distribution
Authors: Uni Daphna , Sheffer Efrat , Klein Tamir , Shem-Tov Rachamim , Segev Nitzan , Winters Gidon
Published: June 2023

Introduction

Soil water availability is a key factor in the growth of trees. In arid deserts, tree growth is limited by very dry soil and atmosphere conditions. Acacia tree species are distributed in the most arid deserts of the globe, therefore they are well adapted to heat and long droughts. Understanding why some plants do better than others in some environments is a key question in plant science.

Methods

Here we conducted a greenhouse experiment to continuously and simultaneously track the whole-plant water-balance of two desert Acacia species, in order to unravel their physiological responses to low water availability.

Results

We found that even under volumetric water content (VWC) of 5-9% in the soil, both species maintained 25% of the control plants, with a peak of canopy activity at noon. Moreover, plants exposed to the low water availability treatment continued growing in this period. A. tortilis applied a more opportunistic strategy than A. raddiana, and showed stomatal responses at a lower VWC (9.8% vs. 13.1%, t4= -4.23, p = 0.006), 2.2-fold higher growth, and faster recovery from drought stress.

Discussion

Although the experiment was done in milder VPD (~3 kPa) compared to the natural conditions in the field (~5 kPa), the different physiological responses to drought between the two species might explain their different topographic distributions. A. tortilis is more abundant in elevated locations with larger fluctuations in water availability while A. raddiana is more abundant in the main channels with higher and less fluctuating water availability. This work shows a unique and non-trivial water-spending strategy in two Acacia species adapted to hyper-arid conditions.
Polyploid GWAS reveals the basis of molecular marker development for complex breeding traits including starch content in the storage roots of sweet potato
Authors: Haque Emdadul , Shirasawa Kenta , Suematsu Keisuke , Tabuchi Hiroaki , Isobe Sachiko , Tanaka Masaru
Published: June 2023

Given the importance of prioritizing genome-based breeding of sweet potato to enable the promotion of food and nutritional security for future human societies, here, we aimed to dissect the genetic basis of storage root starch content (SC) when associated with a complex set of breeding traits including dry matter (DM) rate, storage root fresh weight (SRFW), and anthocyanin (AN) content in a mapping population containing purple-fleshed sweet potato. A polyploid genome-wide association study (GWAS) was extensively exploited using 90,222 single-nucleotide polymorphisms (SNPs) obtained from a bi-parental 204 F1 population between ‘Konaishin’ (having high SC but no AN) and ‘Akemurasaki’ (having high AN content but moderate SC). Through the comparison of polyploid GWAS on the whole set of the 204 F1, 93 high-AN-containing F1, and 111 low-AN-containing F1 populations, a total of two (consists of six SNPs), two (14 SNPs), four (eight SNPs), and nine (214 SNPs) significantly associated signals were identified for the variations of SC, DM, SRFW, and the relative AN content, respectively. Of them, a novel signal associated with SC, which was most consistent in 2019 and 2020 in both the 204 F1 and 111 low-AN-containing F1 populations, was identified in homologous group 15. The five SNP markers associated with homologous group 15 could affect SC improvement with a degree of positive effect (~4.33) and screen high-starch-containing lines with higher efficiency (~68%). In a database search of 62 genes involved in starch metabolism, five genes including enzyme genes granule-bound starch synthase I (IbGBSSI), α-amylase 1D, α-amylase 1E, and α-amylase 3, and one transporter gene ATP/ADP-transporter were located on homologous group 15. In an extensive qRT-PCR of these genes using the storage roots harvested at 2, 3, and 4 months after field transplantation in 2022, IbGBSSI, which encodes the starch synthase isozyme that catalyzes the biosynthesis of amylose molecule, was most consistently elevated during starch accumulation in sweet potato. These results would enhance our understanding of the underlying genetic basis of a complex set of breeding traits in the starchy roots of sweet potato, and the molecular information, particularly for SC, would be a potential platform for molecular marker development for this trait.
Impact of Heartfulness meditation practice on anxiety, perceived stress, well-being, and telomere length
Authors: Thakur Mansee , Patil Yogesh , Philip Sanjana T. , Hamdule Tahreem , Thimmapuram Jayaram , Vyas Nishant , Thakur Kapil
Published: June 2023

Objective

Exhaustion, stress, and burnout have all been found to be reduced using techniques like yoga and meditation. This study was carried out to check the effectiveness of Heartfulness practice (a form of meditation) on certain psychological and genetic variables.

Methods

A total of 100 healthy individuals (aged 18–24) were recruited and randomized into two groups-Heartfulness intervention and control group. The intervention was carried out for 03 months. Participants from both groups were analysed for their cortisol levels and telomere length before and after the intervention. Psychometric measures of anxiety, perceived stress, well-being and mindfulness were carried out using Beck Anxiety Inventory (BAI), Perceived Stress Scale (PSS), WHO-Well-being Index (WHO-WBI) and Five Facet Mindfulness Questionnaire (FFMQ).

Results

The cortisol levels in the meditators group significantly decreased (p < 0.001) after the intervention as compared to the non-meditators group, whereas, the telomere length increased in the mediators group. This increase was not significant (p > 0.05). Anxiety and perceived stress also decreased post intervention, and well-being as well as mindfulness increased, as assessed by the questionnaire tools, although the decrease in perceived stress was statistically insignificant (p > 0.05). A negative correlation was observed between telomere length and cortisol (stress biomarker), whereas a positive correlation was found between telomere length and well-being.

Conclusion

Our data provide evidence that Heartfulness meditation practice can improve our mental health. Additionally, telomere length is shown to be affected by cortisol levels, and this meditation practice can also help to increase telomere length, and thereby slow down cellular aging. However, future studies with larger sample size are required to confirm our observations.
Organizational health climate as a precondition for health-oriented leadership: expanding the link between leadership and employee well-being
Authors: Teetzen Friederike , Klug Katharina , Steinmetz Holger , Gregersen Sabine
Published: June 2023

The link between leadership and employee well-being is long established. In particular, health-oriented leadership is discussed as a leadership style specifically promoting employee well-being. However, the preconditions of health-oriented leadership remain largely unexplored. From the perspective of conservation of resources theory, leaders can only provide resources when receiving some themselves. We propose that organizational health climate (OHC) is an important organization-based resource for a health-oriented leadership style. More specifically, we hypothesize that the relationship between OHC and employee job satisfaction and emotional exhaustion is mediated by health-oriented leadership. We thereby differentiate two levels of analysis: a within-team level and a between-team level. We examined 74 teams with 423 employees of childcare centers at three time points, each 6 months apart. By means of multilevel structural equation modeling, we found OHC to be a significant antecedent of health-oriented leadership at the between-team level. The relationship between OHC and employee job satisfaction was mediated by health-oriented leadership at the between-team level, but not at the within-team level. The relationship between OHC and employee exhaustion showed another pattern of relationships at the different levels of analysis, while it was not significantly mediated by health-oriented leadership. This indicates the value of differentiating between levels of analysis. We discuss the implications for theory and practice that can be drawn from our findings.
Influence of intravenous 10% amino acids infusion on serum albumin concentration in hypoalbuminemic dogs
Authors: Schneider Sabrina , Hartmann Katrin , Dörfelt René
Published: June 2023

Objective

To evaluate the effect of parenteral amino acid application in hospitalized hypoalbuminemic dogs.

Materials and methods

Medical records of client-owned hypoalbuminemic dogs (albumin ≤ 25 g/L) were analyzed. Dogs receiving amino acids for only 1–2 days, receiving transfusions or surgery, or <6 months of age were excluded. Dogs were grouped as those receiving intravenous amino acids (AA, 80 dogs) over 3 days and longer, and those without additional amino acid treatment (CON, 78 dogs). Duration of hospitalization, albumin, and total protein concentrations were compared between groups by Mann–Whitney U test. Course of albumin and total protein concentration was evaluated by Friedman test and Dunn’s multiple comparison test. Significance was set to p ≤ 0.05.

Results

Dogs in group AA received 10% amino acid solution intravenously over median 4 days (3–11 days). No significant differences regarding survival and adverse effects were observed between groups. Dogs of group AA had significantly longer duration of hospitalization (median 8 days; 3–33 days) compared to group CON dogs (median 6 days, 3–24 days; p < 0.001). Initial albumin concentration was lower in group AA compared to CON (p < 0.001). This difference was no longer present on day 2 (p = 0.134).

Conclusions and clinical relevance

Intravenous application of 10% amino acid solution in hypoalbuminemic dogs can improve albumin concentration after 2 days, but does not influence outcome.
Adding a Tail in Classes of Perfect Graphs
Authors: Mpanti Anna , Nikolopoulos Stavros D. , Palios Leonidas
Published: June 2023

Consider a graph G which belongs to a graph class C. We are interested in connecting a node w∉V(G) to G by a single edge uw where u∈V(G); we call such an edge a tail. As the graph resulting from G after the addition of the tail, denoted G+uw, need not belong to the class C, we want to compute the number of non-edges of G in a minimum C-completion of G+uw, i.e., the minimum number of non-edges (excluding the tail uw) to be added to G+uw so that the resulting graph belongs to C. In this paper, we study this problem for the classes of split, quasi-threshold, threshold and P4-sparse graphs and we present linear-time algorithms by exploiting the structure of split graphs and the tree representation of quasi-threshold, threshold and P4-sparse graphs.
An Effective Local Particle Swarm Optimization-Based Algorithm for Solving the School Timetabling Problem
Authors: Tassopoulos Ioannis X. , Iliopoulou Christina A. , Katsaragakis Iosif V. , Beligiannis Grigorios N.
Published: June 2023

This paper deals with the school timetabling problem. The problem was formulated as encountered in a typical Greek high school. A local version of the particle swarm optimization algorithm was developed and applied to the problem at hand. Results on well-established benchmark instances showed that the proposed algorithm achieved the proven optima provided from an integer programming method presented in earlier research. In almost all cases, the current algorithm beat the integer programming method, either concerning the lower bound yielded or the execution time needed.
A Multi-Subsampling Self-Attention Network for Unmanned Aerial Vehicle-to-Ground Automatic Modulation Recognition System
Authors: Shen Yongjian , Yuan Hao , Zhang Pengyu , Li Yuheng , Cai Minkang , Li Jingwen
Published: June 2023

In this paper, we investigate the deep learning applications of radio automatic modulation recognition (AMR) applications in unmanned aerial vehicle (UAV)-to-ground AMR systems. The integration of deep learning in a UAV-aided signal processing terminal can recognize the modulation mode without the provision of parameters. However, the layers used in current models have a small data processing range, and their low noise resistance is another disadvantage. Most importantly, large numbers of parameters and high amounts of computation will burden terminals in the system. We propose a multi-subsampling self-attention (MSSA) network for UAV-to-ground AMR systems, for which we devise a residual dilated module containing ordinary and dilated convolution to expand the data processing range, followed by a self-attention module to improve the classification, even in the presence of noise interference. We subsample the signals to reduce the number of parameters and amount of calculation. We also propose three model sizes, namely large, medium, and small, and the smaller the model, the more suitable it will be for UAV-to-ground AMR systems. We conduct ablation experiments with state-of-the-art and baseline models on the common AMR and radio machine learning (RML) 2018.01a datasets. The proposed method achieves the highest accuracy of 97.00% at a 30 dB signal-to-noise ratio (SNR). The weight file of the small MSSA is only 642 KB.
Structure and Operation Optimization of a Form-Stable Carbonate/Ceramic-Based Electric Thermal Storage Device for Space Heating
Authors: Pan Xinyu , Yuan Mengdi , Xu Guizhi , Hu Xiao , Liao Zhirong , Xu Chao
Published: June 2023

The escalating demand for heating and the widespread use of CO2-emitting fossil fuels during cold seasons have imposed significant pressure on our natural resources. As a promising alternative to coal-fired boilers, electrical thermal storage devices (ETSDs) for space heating are gaining popularity. However, designing ETSDs for space heating involves significant challenges, which involve their storage rate and operational stability. In contrast to the research of directly developing mid-temperature ETSDs to manage heat release during long heating hours, this study proposed a new ETSD that uses K2CO3–Na2CO3 for high-temperature storage to match the off-peak hours and thereby gain potential economic benefits. This study used experimental and simulation methods to investigate the ETSD’s temperature distribution. An operational strategy was also proposed to achieve more efficient temperature distribution and higher economic benefits. The ETSD with two steel plates and two insulation layers with a power rating of 1.6 kW was found to be the optimum structure, due to its improved heat storage rate (2.1 °C/min), uniform temperature, and material heat resistance (<750 °C). An energy analysis, economic analysis, and a 7-day cycling operation performance of the device were then conducted by comparing the proposed ETSD with a traditional electric heater. The results revealed that the proposed ETSD released 53.4% of the stored energy in the room, and stored 48.6% of it during valley electric time. The total cost of the proposed ETSD was consistently lower than the traditional electric heater in the second heating season (by the 213th day). The efficiency of its valley heat storage for users was 37.2%. Overall, this study provides valuable insights into the development and practical applications of ETSD systems for space heating.
Effect of the Volumetric Flow Rate Measurement Methodology of Positive Pressure Ventilators on the Parameters of the Drive Unit
Authors: Warguła Łukasz , Kaczmarzyk Piotr , Lijewski Piotr , Fuć Paweł , Markiewicz Filip , Małozięć Daniel , Wieczorek Bartosz
Published: June 2023

The nature and conditions of the execution of tests (open or duct flow) in terms of evaluating the flow rate generated by positive pressure ventilators (PPV) may affect the parameters of the drive unit recorded during testing. In this article, popular PPVs (conventional type—W1 and turbo type—W2) of about 4.2 kW were tested under open flow (Method A) and duct flow (Method B) conditions. During the tests, engine load values were recorded: torque, speed, horsepower and, using portable emissions measurement systems (PEMS), exhaust gas emissions: carbon monoxide (CO), carbon dioxide (CO2), hydrocarbons (HC), nitrogen oxides (NOx) and fuel consumption. Depending on the method used to measure ventilator flow rates, drive units can have different drive power requirements (from 3.2% to 4.5%). Changes in drive unit operating conditions induced by the flow measurement method are observed in the results of fuel consumption (from 0.65% to 9.8%) and emissions of harmful exhaust compounds: CO2 up to 2.4%, CO up to 67%, HC up to 93.2% and NOx up to 37%. The drive units of turbo type fans (W2) are more susceptible to the influence of the test methods in terms of flow assessment, where they have higher emissions of harmful exhaust gases when tested by Method A. Flow measurement methods affect the oscillation of propulsion power, which contributes to disturbances in the control of the fuel–air mixture composition. The purpose of this article is to analyse the impact of testing methods for measuring the flow rate of positive pressure ventilators on the performance of the drive unit.
A Review of Pumped Hydro Storage Systems
Authors: Nikolaos Papadakis C. , Marios Fafalakis , Dimitris Katsaprakakis
Published: June 2023

With the increasing global demand for sustainable energy sources and the intermittent nature of renewable energy generation, effective energy storage systems have become essential for grid stability and reliability. This paper presents a comprehensive review of pumped hydro storage (PHS) systems, a proven and mature technology that has garnered significant interest in recent years. The study covers the fundamental principles, design considerations, and various configurations of PHS systems, including open-loop, closed-loop, and hybrid designs. Furthermore, the review highlights the crucial role of PHS systems in integrating renewable energy sources, mitigating peak load demands, and enhancing grid stability. An in-depth analysis of current and emerging trends, technical challenges, environmental impacts, and cost-effectiveness is also provided to identify potential areas for future research and development. The paper concludes by offering a perspective on the challenges and opportunities that PHS systems present, underlining their potential to significantly contribute to a sustainable and reliable energy future.
Forecasting the Return of Carbon Price in the Chinese Market Based on an Improved Stacking Ensemble Algorithm
Authors: Ye Peng , Li Yong , Siddik Abu Bakkar
Published: June 2023

Recently, carbon price forecasting has become critical for financial markets and environmental protection. Due to their dynamic, nonlinear, and high noise characteristics, predicting carbon prices is difficult. Machine learning forecasting often uses stacked ensemble algorithms. As a result, common stacking has many limitations when applied to time series data, as its cross-validation process disrupts the temporal sequentiality of the data. Using a double sliding window scheme, we proposed an improved stacking ensemble algorithm that avoided overfitting risks and maintained temporal sequentiality. We replaced cross-validation with walk-forward validation. Our empirical experiment involved the design of two dynamic forecasting frameworks utilizing the improved algorithm. This incorporated forecasting models from different domains as base learners. We used three popular machine learning models as the meta-model to integrate the predictions of each base learner, further narrowing the gap between the final predictions and the observations. The empirical part of this study used the return of carbon prices from the Shenzhen carbon market in China as the prediction target. This verified the enhanced accuracy of the modified stacking algorithm through the use of five statistical metrics and the model confidence set (MCS). Furthermore, we constructed a portfolio to examine the practical usefulness of the improved stacking algorithm. Empirical results showed that the improved stacking algorithm could significantly and robustly improve model prediction accuracy. Support vector machines (SVR) aggregated results better than the other two meta-models (Random forest and XGBoost) in the aggregation step. In different volatility states, the modified stacking algorithm performed differently. We also found that aggressive investment strategies can help investors achieve higher investment returns with carbon option assets.
Comparative Analysis of Fcγ and Complement Receptors Presence on Monocytes in Pulmonary Sarcoidosis and Tuberculosis
Authors: Typiak Marlena , Trzonkowski Piotr , Skotarczak Monika , Dubaniewicz Anna
Published: June 2023

Sarcoidosis (SA) is a granulomatous disorder, which mostly affects the lungs. Its clinical characteristics resemble tuberculosis (TB), but its treatment is different. The etiology of SA is unknown; however, mycobacterial antigens were proposed as environmental factors in its development. Due to previously revealed immunocomplexemia with mycobacterial antigens in the blood of our SA but not TB patients, and in the search for biomarkers for differential diagnosis of the two disorders, we studied the phagocytic activity of monocytes from both patients’ groups with flow cytometry. With the use of this method, we also analyzed the occurrence of receptors for IgG (FcγR) and complement components (CR) at the surface of these monocytes, responsible for phagocytosis of immunocomplexes. We revealed a higher phagocytic activity of monocytes in both disorders, but an increased frequency of monocytes with FcγRIII (CD16) and decreased with CR1 (CD35) receptor in the blood of SA vs. TB patients. With regard to our other genetic study on FcγRIII variants in SA and TB, this may account for the decreased clearance of immunocomplexes and different immune responses in the two diseases. Thus, the presented analysis not only sheds light on the pathomechanisms of SA and TB but may also support their differential diagnosis.
Iron Availability Influences Protein Carbonylation in Arabidopsis thaliana Plants
Authors: Tola Adesola J. , Missihoun Tagnon D.
Published: June 2023

Protein carbonylation is an irreversible form of post-translational modification triggered by reactive oxygen species in animal and plant cells. It occurs either through the metal-catalyzed oxidation of Lys, Arg, Pro, and Thr side chains or the addition of α, β-unsaturated aldehydes and ketones to the side chains of Cys, Lys, and His. Recent genetic studies concerning plants pointed to an implication of protein carbonylation in gene regulation through phytohormones. However, for protein carbonylation to stand out as a signal transduction mechanism, such as phosphorylation and ubiquitination, it must be controlled in time and space by a still unknown trigger. In this study, we tested the hypothesis that the profile and extent of protein carbonylation are influenced by iron homeostasis in vivo. For this, we compared the profile and the contents of the carbonylated proteins in the Arabidopsis thaliana wild-type and mutant-deficient in three ferritin genes under normal and stress conditions. Additionally, we examined the proteins specifically carbonylated in wild-type seedlings exposed to iron-deficient conditions. Our results indicated that proteins were differentially carbonylated between the wild type and the triple ferritin mutant Fer1-3-4 in the leaves, stems, and flowers under normal growth conditions. The profile of the carbonylated proteins was also different between the wild type and the ferritin triple mutant exposed to heat stress, thus pointing to the influence of iron on the carbonylation of proteins. Consistent with this, the exposure of the seedlings to iron deficiency and iron excess greatly influenced the carbonylation of certain proteins involved in intracellular signal transduction, translation, and iron deficiency response. Overall, the study underlined the importance of iron homeostasis in the occurrence of protein carbonylation in vivo.
Fibroblast Growth Factor Signaling in Development and Disease
Authors: Bollenbecker Seth , Barnes Jarrod W. , Krick Stefanie
Published: June 2023

Fibroblast growth factors (FGFs) and their cognate receptors (FGFRs) are important biological molecules with a wide array of pleiotropic functions [...]
Exploring the Potential of Sulfonamide-Dihydropyridine Hybrids as Multitargeted Ligands for Alzheimer’s Disease Treatment
Authors: Dakhlaoui Imen , Bernard Paul J. , Pietrzak Diana , Simakov Alexey , Maj Maciej , Refouvelet Bernard , Béduneau Arnaud , Cornu Raphaël , Jozwiak Krzysztof , Chabchoub Fakher , Iriepa Isabel , Martin Helene , Marco-Contelles José , Ismaili Lhassane
Published: June 2023

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease that has a heavy social and economic impact on all societies and for which there is still no cure. Multitarget-directed ligands (MTDLs) seem to be a promising therapeutic strategy for finding an effective treatment for this disease. For this purpose, new MTDLs were designed and synthesized in three steps by simple and cost-efficient procedures targeting calcium channel blockade, cholinesterase inhibition, and antioxidant activity. The biological and physicochemical results collected in this study allowed us the identification two sulfonamide-dihydropyridine hybrids showing simultaneous cholinesterase inhibition, calcium channel blockade, antioxidant capacity and Nrf2-ARE activating effect, that deserve to be further investigated for AD therapy.
Characterizing the Spatiotemporal Transcriptomic Response of the Right Ventricle to Acute Pressure Overload
Authors: Kheyfets Vitaly O. , Kumar Sushil , Heerdt Paul M. , Ichimura Kenzo , Brown R. Dale , Lucero Melissa , Essafri Ilham , Williams Sarah , Stenmark Kurt R. , Spiekerkoetter Edda
Published: June 2023

This study analyzed microarray data of right ventricular (RV) tissue from rats exposed to pulmonary embolism to understand the initial dynamic transcriptional response to mechanical stress and compare it with experimental pulmonary hypertension (PH) models. The dataset included samples harvested from 55 rats at 11 different time points or RV locations. We performed principal component analysis (PCA) to explore clusters based on spatiotemporal gene expression. Relevant pathways were identified from fast gene set enrichment analysis using PCA coefficients. The RV transcriptomic signature was measured over several time points, ranging from hours to weeks after an acute increase in mechanical stress, and was found to be highly dependent on the severity of the initial insult. Pathways enriched in the RV outflow tracts of rats at 6 weeks after severe PE share many commonalities with experimental PH models, but the transcriptomic signature at the RV apex resembles control tissue. The severity of the initial pressure overload determines the trajectory of the transcriptomic response independent of the final afterload, but this depends on the location where the tissue is biopsied. Chronic RV pressure overload due to PH appears to progress toward similar transcriptomic endpoints.
Recent Experimental Advances in Characterizing the Self-Assembly and Phase Behavior of Polypeptoids
Authors: Kang Liying , Wang Qi , Zhang Lei , Zou Hang , Gao Jun , Niu Kangmin , Jiang Naisheng
Published: June 2023

Polypeptoids are a family of synthetic peptidomimetic polymers featuring N-substituted polyglycine backbones with large chemical and structural diversity. Their synthetic accessibility, tunable property/functionality, and biological relevance make polypeptoids a promising platform for molecular biomimicry and various biotechnological applications. To gain insight into the relationship between the chemical structure, self-assembly behavior, and physicochemical properties of polypeptoids, many efforts have been made using thermal analysis, microscopy, scattering, and spectroscopic techniques. In this review, we summarize recent experimental investigations that have focused on the hierarchical self-assembly and phase behavior of polypeptoids in bulk, thin film, and solution states, highlighting the use of advanced characterization tools such as in situ microscopy and scattering techniques. These methods enable researchers to unravel multiscale structural features and assembly processes of polypeptoids over a wide range of length and time scales, thereby providing new insights into the structure–property relationship of these protein-mimetic materials.
Effect of the Surface Chemical Composition on the Corrosion Resistance in the Mixture of FeCrMoNbB (140MXC) and FeCMnSi (530AS) Coatings Produced with the Electric Wire Arc Spraying Technique: Part I
Authors: Rojas-Molano Héctor F. , Olaya-Flórez Jhon J. , Guzmán-Pardo María A. , Alfonso-Orjuela José E. , Mendieta-Reyes Néstor E.
Published: June 2023

In this study, FeCrMoNbB (140MXC) and FeCMnSi (530AS) coatings were simultaneously projected on the substrate AISI-SAE 4340 using the electric wire arc spraying technique. The projection parameters, such as current (I), voltage (V), primary air pressure (1st), and secondary air pressure (2nd), were determined using the experimental model Taguchi L9 (34−2). Its main purpose is to produce dissimilar coatings and to evaluate the effect of the surface chemical composition on the corrosion resistance in the mixture of 140MXC-530AS as commercial coatings. Three phases were considered to obtain and characterize the coatings: Phase 1: Preparation of materials and projection equipment; Phase 2: Coatings production; and Phase 3: Coatings characterization. The characterization of the dissimilar coatings was carried out using the techniques of Scanning Electron Microscopy (SEM), Energy Dispersive Spectroscopy (EDX), Auger Electronic Spectroscopy (AES), X-ray photoelectron spectroscopy (XPS), and X-ray diffraction (XRD). The results of this characterization corroborated the electrochemical behavior of the coatings. The presence of B was determined with the XPS characterization technique in the mixtures of the coatings in the form of Iron Boride. Moreover, the XRD technique showed Nb in the form of FeNb as a precursor compound for the 140MXC wire powder. The most relevant contributions are the pressures, provided that the quantity of oxides in the coatings decreases with respect to the reaction time between the molten particles and the atmosphere of the projection hood; moreover, for the corrosion potential, the operating voltage of the equipment does not exert any effect since these tend to remain constant.
Control of Tooth Form Deformation in Heat Treatment of Spiral Bevel Gears Based on Reverse Adjustment of Cutting Parameters
Authors: Liu Ganhua , Huo Xiaodong , Deng Shiyi
Published: June 2023

The tooth surface structure of spiral bevel gear is complex and requires high machining accuracy. In order to reduce the tooth form deformation of heat treatment, this paper proposes a reverse adjustment correction model of tooth cutting for heat treatment tooth form deformation of spiral bevel gear. Based on the Levenberg–Marquardat method, a stable and accurate numerical solution for the reverse adjustment amount of the cutting parameters is solved. Firstly, a mathematical model of the tooth surface of spiral bevel gears was established based on the cutting parameters. Secondly, the effect law of each cutting parameter on tooth form was studied by using the method of small variable perturbation. Finally, based on the tooth form error sensitivity coefficient matrix, a reverse adjustment correction model of tooth cutting is established to compensate the heat treatment tooth form deformation by reserving the tooth cutting allowance in the tooth cutting stage. The effectiveness of the reverse adjustment correction model of tooth cutting was verified through experiments on reverse adjustment of tooth cutting processing. The experimental results show that the accumulative tooth form error of the spiral bevel gear after heat treatment is 199.8 μm, which is reduced by 67.71%, and the maximum tooth form error is 8.7 μm, which is reduced by 74.75%, after reverse adjustment of cutting parameters. This research can provide technical support and a theoretical reference for heat treatment tooth form deformation control and high-precision tooth cutting processing of spiral bevel gears.
Experimental Testing and Constitutive Modelling of Pavement Materials
Authors: Liu Xueyan , Zhang Yuqing , You Zhanping , Wang Linbing , Zhou Changhong
Published: June 2023

Pavement materials such as asphalt mixtures, granular aggregates and soils exhibit complex material properties and engineering performance under external loading and environmental conditions [...]
Fish-Derived Protein Hydrolysates Increase Insulin Sensitivity and Alter Intestinal Microbiome in High-Fat-Induced Obese Mice
Authors: Daskalaki Maria G. , Axarlis Konstantinos , Tsoureki Antiopi , Michailidou Sofia , Efraimoglou Christina , Lapi Ioanna , Kolliniati Ourania , Dermitzaki Eirini , Venihaki Maria , Kousoulaki Katerina , Argiriou Anagnostis , Tsatsanis Christos
Published: June 2023

Obesity and type 2 diabetes are characterized by low-grade systemic inflammation and glucose intolerance, which can be partially controlled with nutritional interventions. Protein-containing nutritional supplements possess health-promoting benefits. Herein, we examined the effect of dietary supplementation with protein hydrolysates derived from fish sidestreams on obesity and diabetes, utilizing a mouse model of High-Fat Diet-induced obesity and type 2 diabetes. We examined the effect of protein hydrolysates from salmon and mackerel backbone (HSB and HMB, respectively), salmon and mackerel heads (HSH and HMH, respectively), and fish collagen. The results showed that none of the dietary supplements affected weight gain, but HSH partially suppressed glucose intolerance, while HMB and HMH suppressed leptin increase in the adipose tissue. We further analyzed the gut microbiome, which contributes to the metabolic disease implicated in the development of type 2 diabetes, and found that supplementation with selected protein hydrolysates resulted in distinct changes in gut microbiome composition. The most prominent changes occurred when the diet was supplemented with fish collagen since it increased the abundance of beneficial bacteria and restricted the presence of harmful ones. Overall, the results suggest that protein hydrolysates derived from fish sidestreams can be utilized as dietary supplements with significant health benefits in the context of type 2 diabetes and diet-induced changes in the gut microbiome.
The Anti-Inflammatory Effect of Low Molecular Weight Fucoidan from Sargassum siliquastrum in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages via Inhibiting NF-κB/MAPK Signaling Pathways
Authors: Jayasinghe Arachchige Maheshika Kumari , Kirindage Kirinde Gedara Isuru Sandanuwan , Fernando Ilekuttige Priyan Shanura , Kim Kil-Nam , Oh Jae-Young , Ahn Ginnae
Published: June 2023

Brown seaweed is a rich source of fucoidan, which exhibits a variety of biological activities. The present study discloses the protective effect of low molecular weight fucoidan (FSSQ) isolated from an edible brown alga, Sargassum siliquastrum, on lipopolysaccharide (LPS)-stimulated inflammatory responses in RAW 264.7 macrophages. The findings of the study revealed that FSSQ increases cell viability while decreasing intracellular reactive oxygen species production in LPS-stimulated RAW 264.7 macrophages dose-dependently. FSSQ reduced the iNOS and COX-2 expression, inhibiting the NO and prostaglandin E2 production. Furthermore, mRNA expression of IL-1β, IL-6, and TNF-α was downregulated by FSSQ via modulating MAPK and NF-κB signaling. The NLRP3 inflammasome protein complex, including NLRP3, ASC, and caspase-1, as well as the subsequent release of pro-inflammatory cytokines, such as IL-1β and IL-18, release in LPS-stimulated RAW 264.7 macrophages was inhibited by FSSQ. The cytoprotective effect of FSSQ is indicated via Nrf2/HO-1 signaling activation, which is considerably reduced upon suppression of HO-1 activity by ZnPP. Collectively, the study revealed the therapeutic potential of FSSQ against inflammatory responses in LPS-stimulated RAW 264.7 macrophages. Moreover, the study suggests further investigations on commercially viable methods for fucoidan isolation.
YOLOv5s-Fog: An Improved Model Based on YOLOv5s for Object Detection in Foggy Weather Scenarios
Authors: Meng Xianglin , Liu Yi , Fan Lili , Fan Jingjing
Published: June 2023

In foggy weather scenarios, the scattering and absorption of light by water droplets and particulate matter cause object features in images to become blurred or lost, presenting a significant challenge for target detection in autonomous driving vehicles. To address this issue, this study proposes a foggy weather detection method based on the YOLOv5s framework, named YOLOv5s-Fog. The model enhances the feature extraction and expression capabilities of YOLOv5s by introducing a novel target detection layer called SwinFocus. Additionally, the decoupled head is incorporated into the model, and the conventional non-maximum suppression method is replaced with Soft-NMS. The experimental results demonstrate that these improvements effectively enhance the detection performance for blurry objects and small targets in foggy weather conditions. Compared to the baseline model, YOLOv5s, YOLOv5s-Fog achieves a 5.4% increase in mAP on the RTTS dataset, reaching 73.4%. This method provides technical support for rapid and accurate target detection in adverse weather conditions, such as foggy weather, for autonomous driving vehicles.