bluuebunny/crossref_metadata_2025 huggingface dataset:
Beyond the Obstructive Paradigm: Unveiling the Complex Landscape of Nonobstructive Coronary Artery Disease
Authors: Tudurachi Andreea , Anghel Larisa , Tudurachi Bogdan-Sorin , Zăvoi Alexandra , Ceasovschih Alexandr , Sascău Radu Andy , Stătescu Cristian
Published: August 2024

Traditionally focused on obstructive atherosclerosis, contemporary research indicates that up to 70% of patients undergoing coronary angiography for angina and ischemic symptoms do not exhibit significant stenoses. Nonobstructive coronary artery disease (CAD) has emerged as a prevalent phenotype among these patients. This review emphasizes the emerging understanding that nonobstructive coronary artery disease, encompassing conditions such as ANOCA (Angina with No Obstructive Coronary Artery Disease), INOCA (Ischemia with No Obstructive Coronary Artery Disease), and MINOCA (Myocardial Infarction with No Obstructive Coronary Arteries), represents the most prevalent phenotype in cardiac patients. It delves into the complex pathophysiology underlying these conditions, focusing on microvascular dysfunction and coronary vasoreactivity, which contribute to myocardial ischemia despite the absence of significant coronary obstructions. Additionally, the review critically examines the limitations of current treatments which primarily target obstructive lesions and underscores the necessity for tailored therapies that address the specific microvascular and immunoinflammatory pathways involved in nonobstructive CAD. The main focus of this review is to advocate for a shift in diagnostic and therapeutic strategies to better identify and manage this widely prevalent yet under-recognized subset of CAD.
Effectiveness of Virtual Reality in Occupational Therapy for Post-Stroke Adults: A Systematic Review
Authors: Landim Síbila Floriano , López Roberto , Caris Antonia , Castro Constanza , Castillo Ramon D. , Avello Daniela , Magnani Branco Braulio Henrique , Valdés-Badilla Pablo , Carmine Florencia , Sandoval Cristian , Vásquez Edgar
Published: August 2024

Background: In recent years, there has been a growing use of technological advancements to enhance the rehabilitation of individuals who have suffered from cerebrovascular accidents. Virtual reality rehabilitation programs enable patients to engage in a customized therapy program while interacting with a computer-generated environment. Therefore, our goal was to investigate the effectiveness of virtual reality in occupational therapy for people’s rehabilitation after a cerebrovascular accident. Methods: We systematically searched databases (Pubmed/Medline, Scopus, Web of Science, and Science Direct) for randomized controlled trials published within the last 10 years. Studies involving adult stroke survivors undergoing virtual reality-based interventions aimed at improving upper-extremity motor function were included. The quality assessment followed PRISMA guidelines, with the risk of bias assessed using the Cochrane tool (version 6.4) and methodological quality evaluated using GRADEpro. Results: We selected sixteen studies that met the main criteria for the implementation of virtual reality technology. The interventions described in the articles focused mainly on the upper extremities and their fine motor skills. Conclusions: When used in conventional treatments to improve people’s motor and cognitive functions after a cerebrovascular accident, virtual reality emerges as a beneficial tool. Additionally, virtual reality encourages adherence to the interventional process of rehabilitation through occupational therapy.
Circulating Cell-Free Mitochondrial DNA as a Novel Biomarker for Intra-Amniotic Infection in Obstetrics: A Pilot Trial
Authors: Zeiner Sebastian , Wohlrab Peter , Rosicky Ingo , Schukro Regina Patricia , Klein Klaus Ulrich , Wojta Johann , Speidl Walter , Kiss Herbert , Muin Dana Anaïs
Published: August 2024

Background/Objectives: Intra-amniotic infection (IAI) is a rare but serious condition with potential complications such as preterm labor and intrauterine fetal death. Diagnosing IAI is challenging due to varied clinical signs. Oxidative stress and mitochondrial dysfunction have been hypothesized to evolve around IAI. This study focused on measuring circulating mtDNA levels, a proposed biomarker for mitochondrial dysfunction, in maternal serum and placenta of women with confirmed IAI and healthy controls. Methods: 12 women with confirmed IAI (IAI group) were enrolled following premature preterm rupture of the membranes (PPROM) and compared to 21 healthy women (control group). Maternal blood was obtained two weeks pre-partum and peripartum; furthermore, postpartum placental blood was taken. In the IAI group, maternal blood was taken once weekly until delivery as well as peripartum, as was placental blood. Circulating cell-free mtDNA was quantified by real-time quantitative PCR. Results: Upon admission, in the IAI group, mean plasma mtDNA levels were 735.8 fg/μL compared to 134.0 fg/μL in the control group (p < 0.05). After delivery, in the IAI group, mean mtDNA levels in the placenta were 3010 fg/μL versus 652.4 fg/μL (p < 0.05). Conclusions: Circulating cell-free mtDNA could serve as a valuable biomarker for IAI prediction and diagnosis. Future research should establish reference values for sensitivity in predicting IAI.
Gaps in Education: A Cross-Sectional Survey Study of Knowledge of Advanced Lifesaving Interventions among Canadian Lifeguards
Authors: Huntley Riley , O’Keefe Connor J. , Jaskiewicz Filip , Nadolny Klaudiusz , Wytenbroek Lydia
Published: August 2024

Objective: The aim of this study was to assess lifeguards’ knowledge retention of airway management, oxygen administration, and ventilation interventions following certification and employer-provided training. Methods: This cross-sectional study was conducted using an online survey administered between February and May 2024. A total of 1322 responses from Canadian lifeguards certified in airway management and oxygen administration were deemed eligible for analysis. The survey included 15 knowledge assessment questions, with data analyzed based on lifeguard experience and the date of last certification or in-service training. Results: The mean knowledge assessment score was 10.4 ± 2.2 (69.3 ± 14.6%), with the highest scores in the airway management category and the lowest in the oxygen administration category. Lifeguard experience significantly increased knowledge retention, whereas recertification showed no significant impact, and employer-provided training significantly decreased knowledge retention. Conclusions: The findings underscore the importance of lifeguarding experience in knowledge retention among lifeguards. Optional airway management and oxygen administration recertification, coupled with inconsistent in-service training, have created significant gaps in lifeguard education. This study identifies the need for regular, competency-based training delivered by qualified facilitators. Addressing these gaps is crucial for enhancing the effectiveness of lifeguards in emergency response and ensuring high-quality care for drowning victims.
Novel Method to Measure Volumes of Retinal Specific Entities
Authors: Lippera Myrta , Ferrara Mariantonia , Spiess Karina , Alnafisee Nouf , Ally Naseer , Jalil Assad , Ivanova Tsveta , Moussa George
Published: August 2024

Objectives: The aim of this study is to describe and validate an optical-coherence-tomography (OCT)-based method to easily calculate specific volumes, addressing the limitations of current OCT software in automating volumetric analysis for specific entities in retinal pathologies. Methods: After manually drawing the specific entity on linear OCT scans using the calliper function and automated measurement of its area, the following formula was used for volumetric calculation: Volume [mm3] = ∑area [mm2] × OCT-scan distance [mm]. Retinal volume (RV) was measured by two independent observers in eyes with a normal foveal profile (NFP) and was compared with the automated measurements performed by the OCT software (Engineering GmbH, Heidelberg, Germany); the same process was repeated for the volume of the foveal cavity (FC) or foveoschisis (FS) in eyes with lamellar macular holes (LMHs). Power calculations were conducted to ensure adequate sample size. The measurements were re-acquired after six weeks. Intra- and inter-observer variability as well as comparison to automated RV calculations were analysed. Results: This study included a total of 62 eyes divided into two groups: the NFP (30 eyes) and LMH (32 eyes) groups. The Bland–Altman plots showed a high degree of agreement in both groups for inter-observer and intra-observer agreement. In addition, in the NFP group, a high degree of agreement was demonstrated between human observers and the OCT software (Spectralis). Conclusions: An easy, reliable, and widely applicable method to calculate volumes is described and validated in this paper, showing excellent inter- and intra-observer agreement, which can be applied to any entity requiring a specific study in the context of retinal pathologies.
Multidisciplinary Approach in Atrial Fibrillation: As Good as Gold
Authors: Lucà Fabiana , Abrignani Maurizio Giuseppe , Oliva Fabrizio , Canale Maria Laura , Parrini Iris , Murrone Adriano , Rao Carmelo Massimiliano , Nesti Martina , Cornara Stefano , Di Matteo Irene , Barisone Michela , Giubilato Simona , Ceravolo Roberto , Pignalberi Carlo , Geraci Giovanna , Riccio Carmine , Gelsomino Sandro , Colivicchi Furio , Grimaldi Massimo , Gulizia Michele Massimo
Published: August 2024

Atrial fibrillation (AF) represents the most common sustained arrhythmia necessitating dual focus: acute complication management and sustained longitudinal oversight to modulate disease progression and ensure comprehensive patient care over time. AF is a multifaceted disorder; due to such a great number of potential exacerbating conditions, a multidisciplinary team (MDT) should manage AF patients by cooperating with a cardiologist. Effective management of AF patients necessitates the implementation of a well-coordinated and tailored care pathway aimed at delivering optimized treatment through collaboration among various healthcare professionals. Management of AF should be carefully evaluated and mutually agreed upon in consultation with healthcare providers. It is crucial to recognize that treatment may evolve due to the emergence of new risk factors, symptoms, disease progression, and advancements in treatment modalities. In the context of multidisciplinary AF teams, a coordinated approach involves assembling a diverse team tailored to meet individual patients’ unique needs based on local services’ availability.
The Microbiome in Inflammatory Bowel Disease
Authors: Jauregui-Amezaga Aranzazu , Smet Annemieke
Published: August 2024

The management of patients with inflammatory bowel disease (IBD) aims to control inflammation through the use of immunosuppressive treatments that target various points in the inflammatory cascade. However, the efficacy of these therapies in the long term is limited, and they often are associated with severe side effects. Although the pathophysiology of the disease is not completely understood, IBD is regarded as a multifactorial disease that occurs due to an inappropriate immune response in genetically susceptible individuals. The gut microbiome is considered one of the main actors in the development of IBD. Gut dysbiosis, characterised by significant changes in the composition and functionality of the gut microbiota, often leads to a reduction in bacterial diversity and anti-inflammatory anaerobic bacteria. At the same time, bacteria with pro-inflammatory potential increase. Although changes in microbiome composition upon biological agent usage have been observed, their role as biomarkers is still unclear. While most studies on IBD focus on the intestinal bacterial population, recent studies have highlighted the importance of other microbial populations, such as viruses and fungi, in gut dysbiosis. In order to modulate the aberrant immune response in patients with IBD, researchers have developed therapies that target different players in the gut microbiome. These innovative approaches hold promise for the future of IBD treatment, although safety concerns are the main limitations, as their effects on humans remain unknown.
Psychological Factors Affecting Assertiveness in Subjects with Parkinson’s Disease
Authors: Lo Buono Viviana , Culicetto Laura , Berenati Matteo , Stroscio Giuseppe , Sorbera Chiara , Brigandì Amelia , Marino Silvia , Di Lorenzo Giuseppe , Quartarone Angelo , De Cola Maria Cristina
Published: August 2024

Background/Objectives: Assertiveness, defined as the positive affirmation of oneself, encompasses the ability to refuse requests, express anger, disagree or oppose others, show affection, and uphold personal beliefs without causing conflict. Deficits in assertive behavior are often linked to pathological changes in the basal ganglia and prefrontal dopaminergic systems, commonly observed in Parkinson’s disease (PD), and are predictive of poor clinical outcomes. Psychological factors such as mood alterations and cognitive dysfunction may also impact assertiveness. This study investigated the psychological factors influencing assertiveness in individuals with PD. Methods: A cross-sectional study was conducted, involving 160 patients with PD attending a movement disorders outpatient clinic. The participants underwent assessment using a battery of standardized neuropsychological tests to evaluate cognitive function, assertiveness, mood, dysarthria, and quality of life (QoL). Results: All dimensions of assertiveness correlated with depression and anxiety. Individuals experiencing mood disturbances may struggle to express themselves assertively. Similarly, some dimensions of assertiveness correlated also with the QoL, indicating that, overall, well-being affects assertive behavior. Gender emerged as a significant influencer of assertiveness across all dimensions. Specifically, in subjects with PD, the male gender was associated with lower scores in assertiveness compared to women. No significant correlations were found between assertiveness and dysarthria. Conclusions: The findings highlight the importance of adopting a holistic approach to PD management, addressing not only motor symptoms but also psychological challenges which patients may encounter in their daily lives.
Numerical Study on Optimization of Combustion Cycle Parameters and Exhaust Gas Emissions in Marine Dual-Fuel Engines by Adjusting Ammonia Injection Phases
Authors: Drazdauskas Martynas , Lebedevas Sergejus
Published: August 2024

Decarbonizing maritime transport hinges on transitioning oil-fueled ships (98.4% of the fleet) to renewable and low-carbon fuel types. This shift is crucial for meeting the greenhouse gas (GHG) reduction targets set by the IMO and the EU, with the aim of achieving climate neutrality by 2050. Ammonia, which does not contain carbon atoms that generate CO2, is considered one of the effective solutions for decarbonization in the medium and long term. However, the concurrent increase in nitrogen oxide (NOx) emissions during the ammonia combustion cycle, subject to strict regulation by the MARPOL 73/78 convention, necessitates implementing solutions to reduce them through optimizing the combustion cycle. This publication presents a numerical study on the optimization of diesel and ammonia injection phases in a ship’s medium-speed engine, Wartsila 6L46. The study investigates the exhaust gas emissions and combustion cycle parameters through a high-pressure injection strategy. At an identified 7° CAD injection phase distance between diesel and ammonia, along with an optimal dual-fuel start of injection 10° CAD before TDC, a reduction of 47% in greenhouse gas emissions (GHG = CO2 + CH4 + N2O) was achieved compared to the diesel combustion cycle. This result aligns with the GHG reduction target set by both the IMO and the EU for 2030. Additionally, during the investigation of the thermodynamic combustion characteristics of the cycle, a comparative reduction in NOx of 4.6% was realized. This reduction is linked to the DeNOx process, where the decrease in NOx is offset by an increase in N2O. However, the optimized ammonia combustion cycle results in significant emissions of unburnt NH3, reaching 1.5 g/kWh. In summary, optimizing the combustion cycle of dual ammonia and diesel fuel is essential for achieving efficient and reliable engine performance. Balancing combustion efficiency with emission levels of greenhouse gases, unburned NH3, and NOx is crucial. For the Wartsila 6L46 marine diesel engine, the recommended injection phasing is A710/D717, with a 7° CAD between injection phases.
Research on Aerodynamic Characteristics of Three Offshore Wind Turbines Based on Large Eddy Simulation and Actuator Line Model
Authors: Fu Chen , Zhang Zhihao , Yu Meixin , Zhou Dai , Zhu Hongbo , Duan Lei , Tu Jiahuang , Han Zhaolong
Published: August 2024

Investigating the aerodynamic performance and wake characteristics of wind farms under different levels of wake effects is crucial for optimizing wind farm layouts and improving power generation efficiency. The Large Eddy Simulation (LES)–actuator line model (ALM) method is widely used to predict the power generation efficiency of wind farms composed of multiple turbines. This study employs the LES-ALM method to numerically investigate the aerodynamic performance and wake characteristics of a single NREL 5 MW horizontal-axis wind turbine and three such turbines under different wake interaction conditions. For the single turbine case, the results obtained using the LES-ALM method were compared with the existing literature, showing good agreement and confirming its reliability for single turbine scenarios. For the three-turbine wake field problem, considering the aerodynamic performance differences under three cases, the results indicate that spacing has a minor impact on the power coefficient and thrust coefficient of the middle turbine but a significant impact on the downstream turbine. For staggered three-turbine arrangements, unilateral turbulent inflow to the downstream turbine causes significant fluctuations in thrust and torque, while bilateral turbulent inflow leads to more stable thrust and torque. The presence of two upstream turbines causes an acceleration effect at the inflow region of the downstream single turbine, significantly increasing its power coefficient. The findings of this study can provide methodological references for reducing wake effects and optimizing the layout of wind farms.
An Automatic Detection and Statistical Method for Underwater Fish Based on Foreground Region Convolution Network (FR-CNN)
Authors: Li Shenghong , Li Peiliang , He Shuangyan , Kuai Zhiyan , Gu Yanzhen , Liu Haoyang , Liu Tao , Lin Yuan
Published: August 2024

Computer vision in marine ranching enables real-time monitoring of underwater resources. Detecting fish presents challenges due to varying water turbidity and lighting, affecting color consistency. We propose a Foreground Region Convolutional Neural Network (FR-CNN) that combines unsupervised and supervised methods. It introduces an adaptive multiscale regression Gaussian background model to distinguish fish from noise at different scales. Probability density functions integrate spatiotemporal information for object detection, addressing illumination and water quality shifts. FR-CNN achieves 95% mAP with IoU of 0.5, reducing errors from open-source datasets. It updates anchor boxes automatically on local datasets, enhancing object detection accuracy in long-term monitoring. The results analyze fish species behaviors in relation to environmental conditions, validating the method’s practicality.
Exploring the Potential of Aspergillus oryzae for Sustainable Mycoprotein Production Using Okara and Soy Whey as Cost-Effective Substrates
Authors: Devanthi Putu Virgina Partha , Pratama Ferren , Pramanda Ihsan Tria , Bani Mario Donald , Kadar Adinda Darwati , Kho Katherine
Published: August 2024

Mycoprotein is an alternative protein produced through fungal fermentation. However, it typically relies on refined glucose syrup derived from starch, which can be costly and unsustainable. This study investigates the potential of soybean processing by-products (okara and soy whey) as alternative substrates for producing mycoprotein using Aspergillus oryzae. A. oryzae was cultured for 7 days at 30 °C in diluted okara (1:50) and soy whey (1:1) with or without agitation (100 rpm). Soy whey produced higher biomass yields (369.2–408.8 mg dry biomass/g dry substrate), but had a lower biomass concentration (0.783–0.867 g dry weight/L). Conversely, okara produced a higher biomass concentration (2.02 g dry weight/L) with a yield of 114.7 mg dry biomass/g dry substrate. However, biomass formation in okara was only observed in static conditions, as agitation caused biomass to entangle with soy pulp, hampering its production. Additionally, okara tended to release protein into the media, while soy whey accumulated protein within the biomass, reaching up to 53% w/w protein content. The results of this study provide a promising approach to addressing both soybean processing waste reduction and food security concerns.
Efficacy and Safety of Urethral Catheter with Continuous Infusion of Ropivacaine after Urologic Surgery: A Pilot Prospective Randomized Controlled Trial
Authors: Kim Kwang Taek , Shim Myungsun , Huh Kookjin , Song Sang Hoon , Uhm Young Jun , Son Il Tae , Chung Kyung Jin , Kwak Dae-Kyung , Choi Yi Hwa , Kim Hwanik
Published: August 2024

Background: Catheter-related bladder discomfort (CRBD) has been found in many patients with urologic surgery. The authors investigated the effect of analgesic-eluting urethral catheters on postoperative CRBD. Methods: 60 subjects scheduled for urologic surgery requiring urethral catheterization were randomized prospectively to one of three groups (control arm, 0.5% ropivacaine 1 mL/h arm [Study 1 arm] and 0.5% ropivacaine 2 mL/h arm [Study 2 arm]; n = 20 each). The incidence and severity of CRBD were evaluated postoperatively at 24 h as primary outcomes. The incidence of adverse events regarding urethral catheter utilization was assessed as a secondary outcome. Results: The CRBD incidence at 24 h postoperatively in the control, study 1 and study 2 arms was 50.0%, 10.0%, and 15.0%, respectively (p = 0.002). The CRBD severity at 24 h postoperatively showed that patients in the study 1 and study 2 arms had significantly less postoperative CRBD than those in the control arm (visual analog score [VAS]; the mean VAS of the control, study 1, and study 2 arms: 2.1 vs. 1.6 vs. 0.9, p = 0.045). Urethral pain regarding catheter was significantly less severe in the study arms than in the control (VAS score: 6.2 vs. 1.5 vs. 1.4, p < 0.001). The severity and incidence of adverse events did not differ significantly among groups (p = 0.287). Peri-catheter leakage was more frequent in the study 2 arm (p = 0.057). Conclusion: The proper usage of a ropivacaine-eluting catheter can not only alleviate CRBD but reduce catheter-related urethral pain in patients with urologic surgery followed by catheterization, without major adverse events.
Whole-Body Cryostimulation: An Effective Complementary Treatment in Fibromyalgia? A Follow Up Study
Authors: Verme Federica , Majdič Neža , Modaffari Giuseppe , Alito Angelo , Scarpa Alessandra , Piterà Paolo , Brunani Amelia , Fontana Jacopo Maria , Capodaglio Paolo
Published: August 2024

Recent evidence suggests that whole-body cryostimulation (WBC) may be beneficial for patients with fibromyalgia (FM), but little is known about the duration of such effects. The purpose of this study was to verify the duration of clinical–functional benefits after one cycle of WBC. We conducted a follow-up study on the medium and long-term effects of WBC on well-being, use of pain-relieving/anti-inflammatory medications, pain level, fatigue, sleep quality, and psychological aspects such as mood and anxiety. Twelve months after discharge, we administered a 10 min follow-up telephone interview with FM patients with obesity who had undergone ten 2 min WBC sessions at −110 °C as part of a multidisciplinary rehabilitation program (n = 23) and with patients who had undergone rehabilitation alone (n = 23). Both groups reported positive changes after the rehabilitation program, and similar results regarding fatigue, mood, and anxiety scores; however, the implementation of ten sessions of WBC over two weeks produced additional benefits in pain, general well-being status, and sleep quality with beneficial effects lasting 3–4 months. Therefore, our findings suggest that adding WBC to a rehabilitation program could exert stronger positive effects to improve key aspects of FM such as general well-being, pain level, and sleep quality.
Contribution of Rare Earth Elements Is Key to the Economy of the Future
Authors: Cuadros-Muñoz Juan-Ramón , Jimber-del-Río Juan-Antonio , Sorhegui-Ortega Rafael , Zea-De la Torre Michelle , Vergara-Romero Arnaldo
Published: August 2024

An econometric model was developed to analyze the contribution of various factors to the gross value added to the agricultural, manufacturing, and service sectors in the United States. The study found that variables such as rare earth element mining, the employment it generates, the domestic consumption, imports, and prices of certain elements significantly impact economic sectors. The models showed a good fit and met the necessary statistical assumptions. Rare earth elements are essential for a wide range of technological products, with China being the leading producer and consumer. This has raised concerns about the dependence on other countries. These elements significantly impact the economy’s primary, secondary, and tertiary sectors used in agriculture, manufacturing, and services. Rare earth elements’ mining and processing are complex and expensive processes, and demand is expected to continue to increase in the future.
Regulatory Analysis of Strategic Environmental Assessment Follow-Up
Authors: Reicher Salazar Oscar , Delgado Schneider Verónica , Arumí José Luis
Published: August 2024

The incorporation of environmental variables into policies, programs, plans and projects has been achieved through the use of an Environmental Impact Assessment (EIA). However, the recognition by scholars of several limitations of the EIA has prompted the consideration of Strategic Environmental Assessment (SEA) as the appropriate instrument for achieving this objective. Studies on SEA have concentrated in phases prior to the decision-making, despite the fact that, after the strategic decision has been made, it is also necessary to follow up on the environmental impacts or effects produced by the plan, as well as the possibility of adopting measures to correct them when they cause adverse or unforeseen effects. The way in which this following-up takes place will vary from country to country, based on the respective legal system. Therefore, this study aims to understand these forms of follow-up in urban land planning instruments, at the local level which are legally binding, comparing regulations in France, Portugal and Chile, through three research questions focused on determining whether this phase exists, whether it is possible to modify the local planning instrument in the event of adverse effects and whether there are offset measures for those effects. This study employs a mixed methodology based on the law and content analysis, enabling the identification of pertinent aspects for investigation, the compilation of material for this study, and the answering of research questions through the comparative analysis of the laws of the selected countries. Results show differences and similarities between the regulations of the countries analyzed, regarding the ability to reverse undesired, negative or different effects from those originally considered in urban plans. It will shed light on the possibility for other countries to take follow-up action in the face of undesirable scenarios in the application of planning instruments. The gaps found in our research may also exist in the legislation of other countries.
Research on Improving the Accuracy of SIF Data in Estimating Gross Primary Productivity in Arid Regions
Authors: Liu Wei , Wang Yu , Mamtimin Ali , Liu Yongqiang , Gao Jiacheng , Song Meiqi , Aihaiti Ailiyaer , Wen Cong , Yang Fan , Huo Wen , Zhou Chenglong , Peng Jian , Sayit Hajigul
Published: August 2024

Coupling solar-induced chlorophyll fluorescence (SIF) with gross primary productivity (GPP) for ecological function integration research presents numerous uncertainties, especially in ecologically fragile and climate-sensitive arid regions. Therefore, evaluating the suitability of SIF data for estimating GPP and the feasibility of improving its accuracy in the northern region of Xinjiang is of profound significance for revealing the spatial distribution patterns of GPP and the strong coupling relationship between GPP and SIF in arid regions, achieving the goal of “carbon neutrality” in arid regions. This study is based on multisource SIF satellite data and GPP observation data from sites in three typical ecosystems (cultivated and farmlands, pasture grasslands, and desert vegetation). Two precision improvement methods (canopy and linear) are used to couple multiple indicators to determine the suitability of multisource SIF data for GPP estimation and the operability of accuracy improvement methods in arid regions reveal the spatial characteristics of SIF (GPP). The results indicate the following. (1) The interannual variation of GPP shows an inverted “U” shape, with peaks values in June and July. The cultivated and farmland areas have the highest peak value among the sites (0.35 gC/m2/month). (2) The overall suitability ranking of multisource SIF satellite products for GPP estimation in arid regions is RTSIF > CSIF > SIF_OCO2_005 > GOSIF. RTSIF shows better suitability in the pasture grassland and cultivated and farmland areas (R2 values of 0.85 and 0.84, respectively). (3) The canopy method is suitable for areas with a high leaf area proportion (R2 improvement range: 0.05–0.06), while the linear method is applicable across different surface types (R2 improvement range: 0.01–0.13). However, the improvement effect of the linear method is relatively weaker in areas with high vegetation cover. (4) Combining land use data, the overall improvement of SIF (GPP) is approximately 0.11%, and the peak values of its are mainly distributed in the northern and southern slopes of the Tianshan Mountains, while the low values are primarily found in the Gurbantunggut Desert. The annual mean value of SIF (GPP) is about 0.13 mW/m2/nm/sr. This paper elucidates the applicability of SIF for GPP estimation and the feasibility of improving its accuracy, laying the theoretical foundation for the spatiotemporal coupling study of GPP and SIF in an arid region, and providing practical evidence for achieving carbon neutrality goals.
The Prognostic Role of the Neutrophil-to-Lymphocytes Ratio in the Most Frequent Cardiovascular Diseases: An Update
Authors: Gosav Evelina Maria , Tanase Daniela Maria , Buliga-Finis Oana Nicoleta , Rezuș Ioana-Irina , Morariu Paula Cristina , Floria Mariana , Rezus Ciprian
Published: August 2024

Given the continuous changes in the world, with an increasing trend of unhealthy lifestyles, metabolic comorbidities, and increased susceptibility to cardiovascular diseases (CVDs), researchers change their attention to improve not only the therapeutic platform but also current CVD predictive and prognostic tools to improve disease outcomes. As CVD is characterized by an inflammatory paradigm involving, to some degree, the innate and adaptative immune systems, the neutrophil-to-lymphocyte ratio (NLR) emerged as a potential low-cost, rapidly available, and reliable inflammatory marker, with substantial recent evidence showing its potential utility in clinical practice. Thus, in this literature review, we will present an up-to-date discussion of the prognostic role of NLR in the most frequent CVDs, such as acute and chronic coronary disease, atherosclerotic disease, heart failure, cardiac valvopathies, and cardiac arrhythmias with predilection to atrial fibrillation.
Optimal Network Design for Municipal Waste Management: Application to the Metropolitan City of Rome
Authors: Boresta Marco , Croella Anna Livia , Gentile Claudio , Palagi Laura , Pinto Diego Maria , Stecca Giuseppe , Ventura Paolo
Published: August 2024

Background: This work is part of the regional research project PIPER—Intelligent Platform for the Optimization of Recycling Operations, which aims to develop a network design model for waste collection in the metropolitan city of Rome, Italy. The goal is to enhance the strategic planning of treatment and disposal facilities by incorporating transshipment locations to improve the efficiency of waste collection. The motivation for this study stems from the stringent targets set by the European Green Deal to achieve near-zero emissions and the critical role of waste management in realizing circular economy practices. Methods: The problem is formulated as a mixed integer linear program (MILP) that includes constraints on vehicle allocation to shifts and driver requirements. An additional feature of the model is its ability to account for vehicle maintenance issues when deployed on consecutive shifts. Results: The model was tested against a real-world case study in Rome and demonstrated significant potential savings, with a reduction in total traveled distance exceeding 10%. The mathematical model was also used for evaluating strategic scenarios in a “what-if” analysis, allowing the municipal collection company to assess location options for depots, waste treatment facilities, and transshipment points, as well as to optimize the fleet composition and driver allocation during work shifts. Conclusions: This study presents a robust tool for strategic planning in waste collection operations, highlighting the benefits of using transshipment locations to improve efficiency. The findings indicate substantial potential for cost savings and operational improvements, making the model a valuable asset for municipal waste management planning.
The Structural and Mechanical Properties of Al2O3–Ni Composites Obtained by Magnetic Field-Assisted Centrifugal Slip Casting
Authors: Zygmuntowicz Justyna , Kosiorek Magdalena , Wachowski Marcin , Śnieżek Lucjan , Szachogłuchowicz Ireneusz , Piotrkiewicz Paulina , Kaszuwara Waldemar , Konopka Katarzyna
Published: August 2024

This study investigates the influence of a magnetic field on the microstructure and properties of Al2O3–Ni composites fabricated via centrifugal slip casting at 1500 rpm. Al2O3 and Ni powders were combined with water and deflocculants, homogenized, and then cast into a porous plaster mold surrounded by Nd-Fe-B magnets. The resulting composites, sintered in a reducing atmosphere, exhibited a three-zone structure with varying Ni content due to the combined effects of the magnetic field and centrifugal force. SEM, EDX, and XRD analyses confirmed the distribution and composition of the phases. Hardness tests revealed the highest values at the outermost zone, with a gradual decrease toward the inner zones. Compression tests employing digital image correlation revealed high internal stresses and a significant improvement in compressive strength compared to non-magnetic field methods. This study confirms that magnetic field-assisted centrifugal slip casting significantly enhances the structural, hardness, and compressive strength properties of Al2O3–Ni composites, indicating promising potential for advanced applications.
Thermally Sprayed Coatings for the Protection of Industrial Fan Blades
Authors: Richert Maria
Published: August 2024

This paper presents a study on thermally sprayed coatings. Coatings produced by high-velocity oxygen–fuel spraying HVOF and plasma spraying deposited on the A03590 aluminum casting alloy are tested. The subject of this research concerns coatings based on tungsten carbide WC, chromium carbide Cr3C2, composite coatings NiCrSiB + 2.5%Fe + 2.5%Cr, mixtures of tungsten and chromium powders WC-CrC-Ni, mixtures of carbide powders with the Cr3C2-NiCr + the composite 5% NiCrBSi and WC-Co + 5% NiCrBSi. The aim of this research is to find a coating most resistant to the erosive impact of particles contained in the medium centrifuged by industrial rotors. The suitability of the coating is determined by its high level of microhardness. The hardest coatings are selected from the coatings tested and subjected to abrasion tests against a sand particle impact jet and the centrifugation of a medium with corundum particles. It is found that the most favorable anti-erosion properties are demonstrated by a coating composed of a mixture of tungsten carbide and chromium carbide WC-CrC-Ni powders. It is concluded that the greatest resistance of this coating to the erosive impact of the particle jet results from the synergistic enhancement of the most favorable features of both cermets.
Numerical Study of Tangential Traction Mechanism between Pattern Blocks of Agricultural Radial Tires and Soft Soil
Authors: Li Sheng , Wu Jian , Wan Yang , Su Benlong , Wang Youshan
Published: August 2024

With the increasing requirements of agricultural machinery, the study of the contact relationship between the tire–soil interface and the improvement of traction efficiency has gradually become a main concern. In this study, the pattern on the agricultural tire was simplified into single-pitch pattern blocks. The pattern blocks were made of rubber material that was highly resistant to abrasion and bending. The experiment was carried out by pressing the three types of patterned block construction into the soil and the pure sliding under the soil. The simulation used the Coupled Eulerian–Lagrangian Method (CEL) to verify the experimental results. We found that the herringbone pattern block was subjected to the highest stress for the same depth of downward pressure. The horizontal force generated by the pure sliding was also the highest. The results showed that the numerically simulated and experimentally measured data exhibited similar trends and average values. In addition, the increase in the contact area between the tire and the soil reduced the compaction and sinking of the soil. The herringbone pattern structure not only had a large contact area but also produced the most significant shear force on the soil. Thus, it may generate greater traction in actual operations.
Numerical Simulation and Experimental Study of Carbon Fiber-Reinforced Polymer Single-Bar Extrusion Anchorage Structure
Authors: Zhu Wanxu , Xiong Chengyang , Cheng Boxuan , Shen Quanxi , Cheng Hongbin , Guo Shangqi
Published: August 2024

The reliable anchorage of carbon fiber-reinforced polymer (CFRP) tendons is a critical issue influencing the stable bearing capacity of bridge cables. This study introduces a novel CFRP single-strand extrusion anchoring structure, where the strand is compressed at its end. By integrating this with internal cone filler wrapping, we create a CFRP multi-strand cable composite anchoring system. This innovative design not only minimizes the overall dimensions of the anchoring system but also significantly improves its anchoring efficiency coefficient. An axisymmetric model was developed using ANSYS finite element software. The radial stress distribution and anchorage efficiency coefficient in the anchorage zone of Φ7 CFRP bar and Φ13.6 extrusion die were analyzed with varying parameters, such as chamfering, outer diameter, and length of the extrusion sleeve, and were validated through static load anchorage tests. The results indicate that the highest anchoring efficiency is achieved when four extrusion sleeves with a chamfer angle of 5°, an outer diameter of Φ14.4, and a length of 15 mm are connected in series, reaching a coefficient of 61.04%. Furthermore, this study proposes an anchorage structure where multiple extrusion sleeves are connected in series and sequentially compressed to overcome the limitations of increasing anchorage length for enhancing the anchorage coefficient. The test results demonstrate that with equal total anchorage length, connecting four 15 mm extrusion sleeves in series enhances the anchorage efficiency coefficient by 24.98% compared to a single 60 mm extrusion sleeve structure.
Polydopamine Applications in Biomedicine and Environmental Science
Authors: Omidian Hossein , Wilson Renae L.
Published: August 2024

This manuscript explores the multifaceted applications of polydopamine (PDA) across various scientific and industrial domains. It covers the chemical aspects of PDA and its potential in bone tissue engineering, implant enhancements, cancer treatment, and nanotechnology. The manuscript investigates PDA’s roles in tissue engineering, cell culture technologies, surface modifications, drug delivery systems, and sensing techniques. Additionally, it highlights PDA’s contributions to microfabrication, nanoengineering, and environmental applications. Through detailed testing and assessment, the study identifies limitations in PDA-related research, such as synthesis complexity, incomplete mechanistic understanding, and biocompatibility variability. It also proposes future research directions aimed at improving synthesis techniques, expanding biomedical applications, and enhancing sensing technologies to optimize PDA’s efficacy and scalability.
Soft Robots: Computational Design, Fabrication, and Position Control of a Novel 3-DOF Soft Robot
Authors: Garcia Martin , Esquen Andrea-Contreras , Sabbagh Mark , Grace Devin , Schneider Ethan , Ashuri Turaj , Voicu Razvan Cristian , Tekes Ayse , Amiri Moghadam Amir Ali
Published: August 2024

This paper presents the computational design, fabrication, and control of a novel 3-degrees-of-freedom (DOF) soft parallel robot. The design is inspired by a delta robot structure. It is engineered to overcome the limitations of traditional soft serial robot arms, which are typically low in structural stiffness and blocking force. Soft robotic systems are becoming increasingly popular due to their inherent compliance match to that of human body, making them an efficient solution for applications requiring direct contact with humans. The proposed soft robot consists of three soft closed-loop kinematic chains, each of which includes a soft actuator and a compliant four-bar arm. The complex nonlinear dynamics of the soft robot are numerically modeled, and the model is validated experimentally using a 6-DOF electromagnetic position sensor. This research contributes to the growing body of literature in the field of soft robotics, providing insights into the computational design, fabrication, and control of soft parallel robots for use in a variety of complex applications.
Generalized Fuzzy Rough Approximations on Hypergroups
Authors: Akın Canan , Delice Dilek Bayrak , Yamak Sultan
Published: August 2024

In this paper, we define the fuzzy set-valued homomorphisms of the canonical hypergroups as a generalization of fuzzy congruences and investigate some of their features. This structure is an extension of the definition of set-valued homomorphism defined for groups to hypergroups. With this extension, it has become possible to study generalized fuzzy rough approximations in hyperalgebraic structures such as semihypergroups, polygroups, hyperrings, hypermodules, etc. This paper presents the generalized fuzzy rough approximations based on two-universe (I,T)-fuzzy model on canonical hypergroups.
On Sequential Warped Products Whose Manifold Admits Gradient Schouten Harmonic Solitons
Authors: Yan Lixu , Li Yanlin , Mofarreh Fatemah , Ali Akram , Laurian-Ioan Pişcoran
Published: August 2024

As part of our study, we investigate gradient Schouten harmonic solutions to sequential warped product manifolds. The main contribution of our work is an explanation of how it is possible to express gradient Schouten harmonic solitons on sequential warped product manifolds. Our analysis covers both sequential generalized Robertson–Walker spacetimes and sequential static spacetimes using gradient Schouten harmonic solitons. Studies conducted previously can be generalized from this study.
A Gastrointestinal Image Classification Method Based on Improved Adam Algorithm
Authors: Sun Haijing , Cui Jiaqi , Shao Yichuan , Yang Jiapeng , Xing Lei , Zhao Qian , Zhang Le
Published: August 2024

In this study, a gastrointestinal image classification method based on the improved Adam algorithm is proposed. Gastrointestinal image classification is of great significance in the field of medical image analysis, but it presents numerous challenges, including slow convergence, susceptibility to local minima, and the complexity and imbalance of medical image data. Although the Adam algorithm is widely used in stochastic gradient descent, it tends to suffer from overfitting and gradient explosion issues when dealing with complex data. To address these problems, this paper proposes an improved Adam algorithm, AdamW_AGC, which combines the weight decay and Adaptive Gradient Clipping (AGC) strategies. Weight decay is a common regularization technique used to prevent machine learning models from overfitting. Adaptive gradient clipping avoids the gradient explosion problem by restricting the gradient to a suitable range and helps accelerate the convergence of the optimization process. In order to verify the effectiveness of the proposed algorithm, we conducted experiments on the HyperKvasir dataset and validation experiments on the MNIST and CIFAR10 standard datasets. Experimental results on the HyperKvasir dataset demonstrate that the improved algorithm achieved a classification accuracy of 75.8%, compared to 74.2% for the traditional Adam algorithm, representing an improvement of 1.6%. Furthermore, validation experiments on the MNIST and CIFAR10 datasets resulted in classification accuracies of 98.69% and 71.7%, respectively. These results indicate that the AdamW_AGC algorithm has advantages in handling complex, high-dimensional medical image classification tasks, effectively improving both classification accuracy and training stability. This study provides new ideas and expansions for future optimizer research.
In Silico Identification and Molecular Mechanism of Novel Tyrosinase Inhibitory Peptides Derived from Nacre of Pinctada martensii
Authors: Li Fei , Lin Haisheng , Qin Xiaoming , Gao Jialong , Chen Zhongqin , Cao Wenhong , Zheng Huina , Xie Shaohe
Published: August 2024

Pearl and nacre powders have been valuable traditional Chinese medicines with whitening properties for thousands of years. We utilized a high-temperature and high-pressure method along with compound enzyme digestion to prepare the enzymatic hydrolysates of nacre powder of Pinctada martensii (NP-PMH). The peptides were identified using LC–MS/MS and screened through molecular docking and molecular dynamics simulations. The interactions between peptides and tyrosinase were elucidated through enzyme kinetics, circular dichroism spectropolarimetry, and isothermal titration calorimetry. Additionally, their inhibitory effects on B16F10 cells were explored. The results showed that a tyrosinase-inhibitory peptide (Ala-His-Tyr-Tyr-Asp, AHYYD) was identified, which inhibited tyrosinase with an IC50 value of 2.012 ± 0.088 mM. The results of the in vitro interactions showed that AHYYD exhibited a mixed-type inhibition of tyrosinase and also led to a more compact enzyme structure. The binding reactions of AHYYD with tyrosinase were spontaneous, leading to the formation of a new set of binding sites on the tyrosinase. The B16F10 cell-whitening assay revealed that AHYYD could reduce the melanin content of the cells by directly inhibiting the activity of intracellular tyrosinase. Additionally, it indirectly affects melanin production by acting as an antioxidant. These results suggest that AHYYD could be widely used as a tyrosinase inhibitor in whitening foods and pharmaceuticals.