bluuebunny/crossref_metadata_2025 huggingface dataset:
The Density, Porosity, and Pore Morphology of Fall and Find Ordinary Chondrites
Authors: Li S. J. , Wang S. J. , Miao B. K. , Li Y. , Li X. Y. , Zeng X. J. , Xia Z. P.
Published: October 2019

Density, porosity, and pore morphology constitute the basic physical properties of meteorites. These properties of 214 fragments from 163 different ordinary chondrites (OCs), including falls, non‐Antarctic finds, and Antarctic finds, were measured, calculated, and investigated. Of all the measured OCs data, densities, and porosities of 37 OC falls (14 H, 17 L, and 6 LL), 31 non‐Antarctic finds (9 H and 22 L), and 95 Antarctic finds (24 H and 73 L) are reported for the first time. The individual masses of all the meteorite fragments measured in this study ranged between 0.8953 and 7.7133 g, and these masses were too low to be measured by the Archimedean glass bead method. Our study indicated that the grain density and porosity of find OCs are significantly reduced by terrestrial weathering. As a result, such OCs are not suitable for their physical propertie study. Shock degree ≤S2 slightly increases the measurable porosities of the meteorites by generating a certain amount of tiny cracks in the silicates to connect some isolated pores with the measurable pores. Shock degree over S2 significantly reduces the porosities of meteorites by compacting or even melting the material. Weathering reduced the porosities via space filling of weathering products. Shock load over S2 reduced the porosities of the meteorites by minerals compressing or melting. Moreover, the shock load over S2 also converted intergrain irregular pores into intragrain cracks. Thermal metamorphism mainly changed the pore morphology (size) by pore merging during mineral recrystallization. The pore morphology also plays a significant role in controlling the friability of OCs.
Ionizing radiation induces endothelial transdifferentiation of glioblastoma stem-like cells through the Tie2 signaling pathway
Authors: Deshors Pauline , Toulas Christine , Arnauduc Florent , Malric Laure , Siegfried Aurore , Nicaise Yvan , Lemarié Anthony , Larrieu Dorian , Tosolini Marie , Cohen-Jonathan Moyal Elizabeth , Courtade-Saidi Monique , Evrard Solène M.
Published: October 2019

Glioblastomas (GBM) are brain tumors with a poor prognosis despite treatment that combines surgical resection and radio-chemotherapy. These tumors are characterized by abundant vascularization and significant cellular heterogeneity including GBM stem-like cells (GSC) which contribute to tumor aggressiveness, resistance, and recurrence. Recent data has demonstrated that GSC are directly involved in the formation of new vessels via their transdifferentiation into Tumor Derived Endothelial Cells (TDEC). We postulate that cellular stress such as ionizing radiation (IR) could enhance the transdifferentiation of GSC into TDEC. GSC neurospheres isolated from 3 different patients were irradiated or not and were then transdifferentiated into TDEC. In fact, TDEC obtained from irradiated GSC (TDEC IR+) migrate more towards VEGF, form more pseudotubes in MatrigelTM in vitro and develop more functional blood vessels in MatrigelTM plugs implanted in Nude mice than TDEC obtained from non-irradiated GSC. Transcriptomic analysis allows us to highlight an overexpression of Tie2 in TDEC IR+. All IR-induced effects on TDEC were abolished by using a Tie2 kinase inhibitor, which confirms the role of the Tie2 signaling pathway in this process. Finally, by analyzing Tie2 expression in patient GBMs by immunohistochemistry, we demonstrated that the number of Tie2+ vessels increases in recurrent GBM compared with matched untreated tumors. In conclusion, we demonstrate that IR potentiates proangiogenic features of TDEC through the Tie2 signaling pathway, which indicates a new pathway of treatment-induced tumor adaptation. New therapeutic strategies that associate standard treatment and a Tie2 signaling pathway inhibitor should be considered for future trials.
ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation
Authors: Park Eunhee , Chung Su Wol
Published: October 2019

Ferroptosis is a novel form of programmed cell death in which the accumulation of intracellular iron promotes lipid peroxidation, leading to cell death. Recently, the induction of autophagy has been suggested during ferroptosis. However, this relationship between autophagy and ferroptosis is still controversial and the autophagy-inducing mediator remains unknown. In this study, we confirmed that autophagy is indeed induced by the ferroptosis inducer erastin. Furthermore, we show that autophagy leads to iron-dependent ferroptosis by degradation of ferritin and induction of transferrin receptor 1 (TfR1) expression, using wild-type and autophagy-deficient cells, BECN1+/− and LC3B−/−. Consistently, autophagy deficiency caused depletion of intracellular iron and reduced lipid peroxidation, resulting in cell survival during erastin-induced ferroptosis. We further identified that autophagy was triggered by erastin-induced reactive oxygen species (ROS) in ferroptosis. These data provide evidence that ROS-induced autophagy is a key regulator of ferritin degradation and TfR1 expression during ferroptosis. Our study thus contributes toward our understanding of the ferroptotic processes and also helps resolve some of the controversies associated with this phenomenon.
Association of HLA class I and II gene polymorphisms with acetaminophen-related Stevens–Johnson syndrome with severe ocular complications in Japanese individuals
Authors: Ueta Mayumi , Nakamura Ryosuke , Saito Yoshiro , Tokunaga Katsushi , Sotozono Chie , Yabe Toshio , Aihara Michiko , Matsunaga Kayoko , Kinoshita Shigeru
Published: October 2019

Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute-onset mucocutaneous diseases induced by infectious agents and/or inciting drugs. We have reported that the main causative drugs for SJS/TEN with severe ocular complications (SOC) were cold medicines, including multi-ingredient cold medications and nonsteroidal anti-inflammatory drugs (NSAIDs). Moreover, we also reported that acetaminophen is the most frequent causative drug in various cold medicines. In this study, we focused on acetaminophen-related SJS/TEN with SOC and analyzed HLA-class II (HLA-DRB1, DQB1) in addition to HLA-class I (HLA-A, B, C). We studied the histocompatibility antigen genes HLA-DRB1 and DQB1 in addition to HLA-A, B, and C in 80 Japanese patients with acetaminophen-related SJS/TEN with SOC. We performed polymerase chain reaction amplification followed by hybridization with sequence-specific oligonucleotide probes (PCR-SSO) using commercial bead-based typing kits. We also used genotyped data from 113 healthy volunteers for HLA-DRB1 and DQB1, and 639 healthy volunteers for HLA-A, B, and C. HLA-DRB1*08:03 and DRB1*12:02 were associated with acetaminophen-related SJS/TEN with SOC, although the results ceased to be significant when we corrected the p-value for the number of alleles detected. HLA-A*02:06 was strongly associated with acetaminophen-related SJS/TEN with SOC (carrier frequency: p = 4.7 × 10−12, Pc = 6.6 × 10−11, OR = 6.0; gene frequency: p = 8.0 × 10−13, Pc = 1.1 × 10−11, OR = 4.9). HLA-B*13:01 (carrier frequency: p = 2.0 × 10−3, Pc = 0.042, OR = 4.1; gene frequency: p = 2.2 × 10−3, Pc = 0.047, OR = 3.9), HLA-B*44:03 (carrier frequency: p = 2.1 × 10−3, Pc = 0.045, OR = 2.4) and HLA-C*14:03 (carrier frequency: p = 3.4 × 10−3, Pc = 0.045, OR = 2.3) were also significantly associated, while HLA-A*24:02 was inversely associated (gene frequency: p = 6.3 × 10−4, Pc = 8.8 × 10−3, OR = 0.5). Acetaminophen-related SJS/TEN with SOC was not associated with HLA-class II (HLA-DRB1, DQB1). However, for acetaminophen-related SJS/TEN with SOC, we found an association with HLA-B*13:01 and HLA- C*14:03 in addition to HLA-A*02:06 and HLA-B*44:03, which have been described previously.
Identification of a novel synthetic lethal vulnerability in non-small cell lung cancer by co-targeting TMPRSS4 and DDR1
Authors: Villalba Maria , Redin Esther , Exposito Francisco , Pajares Maria Jose , Sainz Cristina , Hervas David , Guruceaga Elizabeth , Diaz-Lagares Angel , Cirauqui Cristina , Redrado Miriam , Valencia Karmele , de Andrea Carlos , Jantus-Lewintre Eloisa , Camps Carlos , Lopez-Lopez Rafael , Lahoz Agustin , Montuenga Luis , Pio Ruben , Sandoval Juan , Calvo Alfonso
Published: October 2019

Finding novel targets in non-small cell lung cancer (NSCLC) is highly needed and identification of synthetic lethality between two genes is a new approach to target NSCLC. We previously found that TMPRSS4 promotes NSCLC growth and constitutes a prognostic biomarker. Here, through large-scale analyses across 5 public databases we identified consistent co-expression between TMPRSS4 and DDR1. Similar to TMPRSS4, DDR1 promoter was hypomethylated in NSCLC in 3 independent cohorts and hypomethylation was an independent prognostic factor of disease-free survival. Treatment with 5-azacitidine increased DDR1 levels in cell lines, suggesting an epigenetic regulation. Cells lacking TMPRSS4 were highly sensitive to the cytotoxic effect of the DDR1 inhibitor dasatinib. TMPRSS4/DDR1 double knock-down (KD) cells, but not single KD cells suffered a G0/G1 cell cycle arrest with loss of E2F1 and cyclins A and B, increased p21 levels and a larger number of cells in apoptosis. Moreover, double KD cells were highly sensitized to cisplatin, which caused massive apoptosis (~40%). In vivo studies demonstrated tumor regression in double KD-injected mice. In conclusion, we have identified a novel vulnerability in NSCLC resulting from a synthetic lethal interaction between DDR1 and TMPRSS4.
A murine model demonstrating reversal of structural and functional correlates of cirrhosis with progenitor cell transplantation
Authors: Muthiah Mark D. , Huang Daniel Q. , Zhou Lei , Jumat Nur Halisah , Choolani Mahesh , Chan Jerry Kok Yen , Wee Aileen , Lim Seng Gee , Dan Yock-Young
Published: October 2019

Development of cell transplantation for treating liver cirrhosis hinges critically on the availability of animal models for studying human stem cell transplantation. We report an immune-permissive murine model of liver cirrhosis with full clinical correlates of decompensated liver disease, and allows testing efficacy of stem cell transplantation. Liver cirrhosis was induced in Nod-scid gamma(NSG) mice with oral thioacetamide(TA) and compared to controls over 12 months. 4 month TA treated cirrhotic mice were then transplanted intrasplenically with 2million human fetal liver progenitor cells(HFH) and compared with cirrhotic controls 2 months after transplantation. NSG-TA mice developed shrunken and nodular livers with histological evidence of fibrosis as compared to controls. This was associated with evidence of worsening decompensated liver disease, with jaundice, hypoalbuminemia, coagulopathy, and encephalopathy in NSG-TA mice. Transplantation of HFH resulted in improvement in both fibrosis and markers of decompensated liver disease. We have demonstrated that NSG-TA mice can recapitulate the full clinical picture of structural and functional cirrhosis, both of which can be improved by transplantation of human fetal liver cells. This model serves as a valuable tool for validation of in vivo liver stem cell transplantation and opens up opportunities for studying the mechanism how stem cells reverse fibrosis.
Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and serum
Authors: Rajan Meenu Rohini , Sotak Matus , Barrenäs Fredrik , Shen Tong , Borkowski Kamil , Ashton Nicholas J. , Biörserud Christina , Lindahl Tomas L. , Ramström Sofia , Schöll Michael , Lindahl Per , Fiehn Oliver , Newman John W. , Perkins Rosie , Wallenius Ville , Lange Stephan , Börgeson Emma
Published: October 2019

The search for biomarkers associated with obesity-related diseases is ongoing, but it is not clear whether plasma and serum can be used interchangeably in this process. Here we used high-throughput screening to analyze 358 proteins and 76 lipids, selected because of their relevance to obesity-associated diseases, in plasma and serum from age- and sex-matched lean and obese humans. Most of the proteins/lipids had similar concentrations in plasma and serum, but a subset showed significant differences. Notably, a key marker of cardiovascular disease PAI-1 showed a difference in concentration between the obese and lean groups only in plasma. Furthermore, some biomarkers showed poor correlations between plasma and serum, including PCSK9, an important regulator of cholesterol homeostasis. Collectively, our results show that the choice of biofluid may impact study outcome when screening for obesity-related biomarkers and we identify several markers where this will be the case.
Target site as the main mechanism of resistance to imazamox in a Euphorbia heterophylla biotype
Authors: Rojano-Delgado Antonia M. , Portugal João M. , Palma-Bautista Candelario , Alcántara-de la Cruz Ricardo , Torra Joel , Alcántara Esteban , De Prado Rafael
Published: October 2019

Euphorbia heterophylla is a weed species that invades extensive crop areas in subtropical regions of Brazil. This species was previously controlled by imazamox, but the continuous use of this herbicide has selected for resistant biotypes. Two biotypes of E. heterophylla from southern Brazil, one resistant (R) and one susceptible (S) to imazamox, were compared. The resistance of the R biotype was confirmed by dose-response assays since it required 1250.2 g ai ha−1 to reduce the fresh weight by 50% versus 7.4 g ai ha−1 for the S biotype. The acetolactate synthase (ALS) enzyme activity was studied using ALS-inhibiting herbicides from five different chemical families. The R biotype required the highest concentrations to reduce this enzyme activity by 50%. A Ser653Asn mutation was found in the ALS gene of the R biotype. The experiments carried out showed that imazamox absorption and metabolism were not involved in resistance. However, greater 14C-imazamox root exudation was found in the R biotype (~70% of the total absorbed imazamox). Target site mutation in the ALS gene is the principal mechanism that explains the imazamox resistance of the R biotype, but root exudation seems to also contribute to the resistance of this biotype.
Competition structured a Late Cretaceous megaherbivorous dinosaur assemblage
Authors: Mallon Jordan C.
Published: October 2019

Modern megaherbivore community richness is limited by bottom-up controls, such as resource limitation and resultant dietary competition. However, the extent to which these same controls impacted the richness of fossil megaherbivore communities is poorly understood. The present study investigates the matter with reference to the megaherbivorous dinosaur assemblage from the middle to upper Campanian Dinosaur Park Formation of Alberta, Canada. Using a meta-analysis of 21 ecomorphological variables measured across 14 genera, contemporaneous taxa are demonstrably well-separated in ecomorphospace at the family/subfamily level. Moreover, this pattern is persistent through the approximately 1.5 Myr timespan of the formation, despite continual species turnover, indicative of underlying structural principles imposed by long-term ecological competition. After considering the implications of ecomorphology for megaherbivorous dinosaur diet, it is concluded that competition structured comparable megaherbivorous dinosaur communities throughout the Late Cretaceous of western North America.
Higher Toughness of Metal-nanoparticle-implanted Sodalime Silicate Glass with Increased Ductility
Authors: Ono Madoka , Miyasaka Satoshi , Takato Yoichi , Urata Shingo , Yoshino Haruhiko , Ando Ryota , Hayashi Yasuo
Published: October 2019

In this report, we propose a novel framework for toughening brittle oxide glass originated from enhanced ductility by implanting a secondary material comprising different mechanical properties. To do so, copper-metal nanoparticles are implanted into the subsurface layer of commercial soda-lime silica glass by using the electrofloat method. The crack initiation load of the implanted glass is found to be comparable to the glass chemically strengthened in ordinary tempering conditions. By observing crack propagation and stress distribution from cross-section, it is found that the crack propagation stops within the metal nanoparticle implanted layer, due to the stress dissipation or relaxation. The copper-implanted glass shows improved toughness with decreased hardness. The toughening mechanism of the composite glass is theoretically studied using molecular dynamics calculations on an amorphous silica model with copper nanoparticles embedded, and Peridynamics fracture simulations for indentation on a glass sheet model whose surface was implicitly modeled as the copper-implanted oxide glass. The experimentally observed phenomena of intrinsic toughening were well explained by the series of the conducted simulations.
Proteins and microRNAs are differentially expressed in tear fluid from patients with Alzheimer’s disease
Authors: Kenny Aidan , Jiménez-Mateos Eva M. , Zea-Sevilla María Ascensión , Rábano Alberto , Gili-Manzanaro Pablo , Prehn Jochen H. M. , Henshall David C. , Ávila Jesús , Engel Tobias , Hernández Félix
Published: October 2019

Alzheimer’s disease (AD) is characterized by a progressive loss of neurons and cognitive functions. Therefore, early diagnosis of AD is critical. The development of practical and non-invasive diagnostic tests for AD remains, however, an unmet need. In the present proof-of-concept study we investigated tear fluid as a novel source of disease-specific protein and microRNA-based biomarkers for AD development using samples from patients with mild cognitive impairment (MCI) and AD. Tear protein content was evaluated via liquid chromatography-mass spectrometry and microRNA content was profiled using a genome-wide high-throughput PCR-based platform. These complementary approaches identified enrichment of specific proteins and microRNAs in tear fluid of AD patients. In particular, we identified elongation initiation factor 4E (eIF4E) as a unique protein present only in AD samples. Total microRNA abundance was found to be higher in tears from AD patients. Among individual microRNAs, microRNA-200b-5p was identified as a potential biomarker for AD with elevated levels present in AD tear fluid samples compared to controls. Our study suggests that tears may be a useful novel source of biomarkers for AD and that the identification and verification of biomarkers within tears may allow for the development of a non-invasive and cost-effective diagnostic test for AD.
Spatial ecology of male hippopotamus in a changing watershed
Authors: Stears Keenan , Nuñez Tristan A. , Muse Epaphras A. , Mutayoba Benezeth M. , McCauley Douglas J.
Published: October 2019

The obligate dependency of the common hippopotamus, Hippopotamus amphibius, on water makes them particularly vulnerable to hydrological disturbances. Despite the threats facing this at-risk species, there is a lack of information regarding H. amphibius spatial ecology. We used high-resolution tracking data of male H. amphibius to assess home range size, movement mode (e.g. residency and migratory movements), and resource selection patterns. We compared these results across seasons to understand how hydrological variability influences H. amphibius movement. Our study watershed has been severely impacted by anthropogenic water abstraction causing the river to stop flowing for prolonged periods. We observed H. amphibius movements to be highly constrained to the river course with grassy floodplains being their preferred habitat. Dominant and small sub-adult males displayed year-round residency in/near river pools and had smaller home ranges compared to large sub-adults. During the dry season, large sub-adult males made significant (~15 km) upstream movements. The larger home range size of large sub-adults can be attributed to the elevated levels of migratory and exploratory activities to limit conspecific aggression as the river dries. Our observations provide insight into how future changes in water flow may influence male H. amphibius movements and populations through density-dependent effects.
Evolution and diversity of transposable elements in fish genomes
Authors: Shao Feng , Han Minjin , Peng Zuogang
Published: October 2019

Transposable elements (TEs) are genomic sequences that can move, multiply, and often form sizable fractions of vertebrate genomes. Fish belong to a unique group of vertebrates, since their karyotypes and genome sizes are more diverse and complex, with probably higher diversity and evolution specificity of TE. To investigate the characteristics of fish TEs, we compared the mobilomes of 39 species, and observed significant variation of TE content in fish (from 5% in pufferfish to 56% in zebrafish), along with a positive correlation between fish genome size and TE content. In different classification hierarchies, retrotransposons (class), long terminal repeat (order), as well as Helitron, Maverick, Kolobok, CMC, DIRS, P, I, L1, L2, and 5S (superfamily) were all positively correlated with fish genome size. Consistent with previous studies, our data suggested fish genomes to not always be dominated by DNA transposons; long interspersed nuclear elements are also prominent in many species. This study suggests CR1 distribution in fish genomes to be obviously regular, and provides new clues concerning important events in vertebrate evolution. Altogether, our results highlight the importance of TEs in the structure and evolution of fish genomes and suggest fish species diversity to parallel transposon content diversification.
Shear-induced microstructures and dynamics processes of phospholipid cylinders in solutions
Authors: Shan Yue , Qiang Xiaowei , Ye Jianzhu , Wang Xianghong , He Linli , Li Shiben
Published: October 2019

Shear-induced microstructures and their corresponding dynamic processes are investigated for phospholipid cylinders in aqueous solution by dissipative particle dynamic simulation. Various phospholipid cylinders with cross-sections, which are formed under shear-free flow, are selected to examine the effects of shear flow on their structures and dynamic processes. Shear flow induces the transition from cylinders into vesicles at weak rate and the transition into vesicle–lamella mixtures with increased shear rate and lamella structures at the strong shear rate. Then, the average radius of gyration and shape factors of the polymer chains in the dynamic processes are discussed in detail. Results show that shear flow causes the structure of the polymer chains to be elongated along the shear direction, and the configuration of the polymer chain can be rapidly transformed into an ellipsoid structure under strong shear.
Central metabolism of functionally heterogeneous mesenchymal stromal cells
Authors: Barilani Mario , Palorini Roberta , Votta Giuseppina , Piras Roberta , Buono Giuseppe , Grassi Michela , Bollati Valentina , Chiaradonna Ferdinando , Lazzari Lorenza
Published: October 2019

Metabolism and mitochondrial biology have gained a prominent role as determinants of stem cell fate and function. In the context of regenerative medicine, innovative parameters predictive of therapeutic efficacy could be drawn from the association of metabolic or mitochondrial parameters to different degrees of stemness and differentiation potentials. Herein, this possibility was addressed in human mesenchymal stromal/stem cells (hMSC) previously shown to differ in lifespan and telomere length. First, these hMSC were shown to possess significantly distinct proliferation rate, senescence status and differentiation capacity. More potential hMSC were associated to higher mitochondrial (mt) DNA copy number and lower mtDNA methylation. In addition, they showed higher expression levels of oxidative phosphorylation subunits. Consistently, they exhibited higher coupled oxygen consumption rate and lower transcription of glycolysis-related genes, glucose consumption and lactate production. All these data pointed at oxidative phosphorylation-based central metabolism as a feature of higher stemness-associated hMSC phenotypes. Consistently, reduction of mitochondrial activity by complex I and III inhibitors in higher stemness-associated hMSC triggered senescence. Finally, functionally higher stemness-associated hMSC showed metabolic plasticity when challenged by glucose or glutamine shortage, which mimic bioenergetics switches that hMSC must undergo after transplantation or during self-renewal and differentiation. Altogether, these results hint at metabolic and mitochondrial parameters that could be implemented to identify stem cells endowed with superior growth and differentiation potential.
Inhibition of translation termination by small molecules targeting ribosomal release factors
Authors: Ge Xueliang , Oliveira Ana , Hjort Karin , Bergfors Terese , Gutiérrez-de-Terán Hugo , Andersson Dan I. , Sanyal Suparna , Åqvist Johan
Published: October 2019

The bacterial ribosome is an important drug target for antibiotics that can inhibit different stages of protein synthesis. Among the various classes of compounds that impair translation there are, however, no known small-molecule inhibitors that specifically target ribosomal release factors (RFs). The class I RFs are essential for correct termination of translation and they differ considerably between bacteria and eukaryotes, making them potential targets for inhibiting bacterial protein synthesis. We carried out virtual screening of a large compound library against 3D structures of free and ribosome-bound RFs in order to search for small molecules that could potentially inhibit termination by binding to the RFs. Here, we report identification of two such compounds which are found both to bind free RFs in solution and to inhibit peptide release on the ribosome, without affecting peptide bond formation.
The gynoecious CmWIP1 transcription factor interacts with CmbZIP48 to inhibit carpel development
Authors: Eleblu John S. Y. , Haraghi Aimen , Mania Brahim , Camps Celine , Rashid Dali , Morin Halima , Dogimont Catherine , Boualem Adnane , Bendahmane Abdelhafid
Published: October 2019

In angiosperms, sex determination leads to development of unisexual flowers. In Cucumis melo, development of unisexual male flowers results from the expression of the sex determination gene, CmWIP1, in carpel primordia. To bring new insight on the molecular mechanisms through which CmWIP1 leads to carpel abortion in male flowers, we used the yeast two-hybrid approach to look for CmWIP1-interacting proteins. We found that CmWIP1 physically interacts with an S2 bZIP transcription factor, CmbZIP48. We further determined the region mediating the interaction and showed that it involves the N-terminal part of CmWIP1. Using laser capture microdissection coupled with quantitative real-time gene expression analysis, we demonstrated that CmWIP1 and CmbZIP48 share a similar spatiotemporal expression pattern, providing the plant organ context for the CmWIP1-CmbZIP48 protein interaction. Using sex transition mutants, we demonstrated that the expression of the male promoting gene CmWIP1 correlates with the expression of CmbZIP48. Altogether, our data support a model in which the coexpression and the physical interaction of CmWIP1 and CmbZIP48 trigger carpel primordia abortion, leading to the development of unisexual male flowers.
Joint action goals reduce visuomotor interference effects from a partner’s incongruent actions
Authors: Clarke Sam , McEllin Luke , Francová Anna , Székely Marcell , Butterfill Stephen A. , Michael John
Published: October 2019

Joint actions often require agents to track others’ actions while planning and executing physically incongruent actions of their own. Previous research has indicated that this can lead to visuomotor interference effects when it occurs outside of joint action. How is this avoided or overcome in joint actions? We hypothesized that when joint action partners represent their actions as interrelated components of a plan to bring about a joint action goal, each partner’s movements need not be represented in relation to distinct, incongruent proximal goals. Instead they can be represented in relation to a single proximal goal – especially if the movements are, or appear to be, mechanically linked to a more distal joint action goal. To test this, we implemented a paradigm in which participants produced finger movements that were either congruent or incongruent with those of a virtual partner, and either with or without a joint action goal (the joint flipping of a switch, which turned on two light bulbs). Our findings provide partial support for the hypothesis that visuomotor interference effects can be reduced when two physically incongruent actions are represented as mechanically interdependent contributions to a joint action goal.
Silicon-doped graphene edges: an efficient metal-free catalyst for the reduction of CO2 into methanol and ethanol
Authors: Mao Xin , Kour Gurpreet , Zhang Lei , He Tianwei , Wang Sufan , Yan Cheng , Zhu Zhonghua , Du Aijun
Published: October 2019

Si doped graphene as a metal-free catalyst to convert CO2 to methanol and ethanol with high selectivity and activity.
A sulfonated cobalt phthalocyanine/carbon nanotube hybrid as a bifunctional oxygen electrocatalyst
Authors: Li Chuan , Huang Tianxiang , Huang Zhaodi , Sun Jianpeng , Zong Cheng , Yang Jingge , Deng Wenan , Dai Fangna
Published: October 2019

With the sulfur modified CoN4 sites and the conductive CNT, the CoPc-SO3H/CNT hybrid exhibits ORR/OER bifunctional activity.
Dioxygen reactivity of iron(ii)–gentisate/1,4-dihydroxy-2-naphthoate complexes of N4 ligands: oxidative coupling of 1,4-dihydroxy-2-naphthoate
Authors: Rahaman Rubina , Munshi Sandip , Banerjee Sridhar , Chakraborty Biswarup , Bhunia Sarmistha , Paine Tapan Kanti
Published: October 2019

Oxidative C–C coupling of iron-coordinated co-ligand: Iron(ii)-1,4-dihydroxy-2-naphthoate complexes of neutral N4 ligands react with dioxygen to display C–C coupling of 1,4-dihydroxy-2-naphthoate.
A small-sized and stable 2D metal–organic framework: a functional nanoplatform for effective photodynamic therapy
Authors: Gao Zhiguo , Chen Fanghui , Li Yaojia , Zhang Yu , Cheng Kaiwu , An Peijing , Sun Baiwang
Published: October 2019

A small-sized 2D metal–organic framework with remarkable ROS generation ability through enhanced intersystem crossing.
Sr5TeO2(BO3)4 and NaSr5(BO3)(SiO4)2: two inorganic metal borate derivatives with diverse zero dimensional anions
Authors: Tang Ruling , Hu Chunli , Feng Jianghe , Fang Zhi , Chen Yan , Kong Fang , Mao Jianggao
Published: October 2019

Two new inorganic metal borate derivatives, Sr5TeO2(BO3)4 and NaSr5(BO3)(SiO4)2, have been obtained through a high temperature solid reaction method.
Gamma radiolysis of hydrophilic diglycolamide ligands in concentrated aqueous nitrate solution
Authors: Horne Gregory P. , Wilden Andreas , Mezyk Stephen P. , Twight Liam , Hupert Michelle , Stärk Andrea , Verboom Willem , Mincher Bruce J. , Modolo Giuseppe
Published: October 2019

Advanced analytical techniques and predictive multi-scale modeling calculations show that gamma radiolysis of hydrophilic diglycolamides in concentrated, aqueous nitrate solutions is significantly slower and less structurally sensitive than under pure water conditions.
Correction: Indolizine quaternary ammonium salt inhibitors part II: a reinvestigation of an old-fashioned strong acid corrosion inhibitor phenacyl quinolinium bromide and its indolizine derivative
Authors: Wang Yefei , Yang Zhen , Zhan Fengtao , LYu Zhifeng , Han Chengyou , Wang Xiaonuo , Chen Wuhua , Ding Mingchen , Wang Renzhuo , Jiang Yingnan
Published: October 2019

Correction for ‘Indolizine quaternary ammonium salt inhibitors part II: a reinvestigation of an old-fashioned strong acid corrosion inhibitor phenacyl quinolinium bromide and its indolizine derivative’ by Yefei Wang et al., New J. Chem., 2018, 42, 12977–12989.
A bromine-catalysis-synthesized poly(3,4-ethylenedioxythiophene)/graphitic carbon nitride electrochemical sensor for heavy metal ion determination
Authors: Wu Wei , Ali Ahmat , Jamal Ruxangul , Abdulla Mihray , Bakri Tursunnisahan , Abdiryim Tursun
Published: October 2019

The PEDOT/g-C3N4composite prepared by a Br2-catalyzed polymerization method exhibited the widest linear electrochemical responses for Cd2+and Pb2+.
Mechanical and thermal properties and cytotoxicity of Al2O3 nano particle-reinforced poly(ether-ether-ketone) for bone implants
Authors: Wei Tianyue , Wang Jin , Yu Xunzhi , Wang Youfa , Wu Qingzhi , Chen Chang
Published: October 2019

A novel preparation method for a PEEK/Al2O3 composite biomaterial for human bone implantation was proposed.
TiBALDH as a precursor for biomimetic TiO2 synthesis: stability aspects in aqueous media
Authors: Hernández-Gordillo Armin , Hernández-Arana Andrés , Campero-Celis Antonio , Vera-Robles L. Irais
Published: October 2019

Factors affecting TiO2 biomineralization using TiBALDH as precursor.
Vapor-fed electrolysis of water using earth-abundant catalysts in Nafion or in bipolar Nafion/poly(benzimidazolium) membranes
Authors: Giesbrecht Patrick K. , Müller Astrid M. , Read Carlos G. , Holdcroft Steven , Lewis Nathan S. , Freund Michael S.
Published: October 2019

Vapor-fed electrolysis of water has been performed using membrane-electrode assemblies (MEAs) incorporating earth-abundant catalysts and bipolar membranes (BPMs).
A statistical method for the identification of stars enriched in neutron-capture elements from medium-resolution spectra
Authors: Navó G. , Tous J. L. , Solanes J. M.
Published: October 2019

We present an automated statistical method that uses medium-resolution spectroscopic observations of a set of stars to select those that show evidence of possessing significant amounts of neutron-capture elements. Our tool was tested against a sample of ∼70 000 F- and G-type stars distributed among 215 plates from the Galactic Understanding and Exploration (SEGUE) survey, including 13 that were directed at stellar Galaxy clusters. Focusing on five spectral lines of europium in the visible window, our procedure ranked the stars by their likelihood of having enhanced content of this atomic species and identifies the objects that exhibit signs of being rich in neutron-capture elements as those scoring in the upper 2.5%. We find that several of the cluster plates contain relatively large numbers of stars with significant absorption around at least three of the five selected lines. The most prominent is the globular cluster M 3, where we measured a fraction of stars that are potentially rich in heavy nuclides, representing at least 15%.
Aquifer System, Recharge-Discharge Zone and Groundwater Basin Boundary Mapping to Support Open and Transparent Water Data, Case Study: Karangkobar Groundwater Basin
Authors: Putranto Thomas Triadi , Luthfi Muhammad Iman , Qadaryati Nurakhmi , Santi Narulita , Hidajat Wahju Krisna
Published: October 2019

Sustainable groundwater management based on groundwater basin (GWB) must be equipped with comprehensive information including the characteristic of hydrogeology. This management method is very useful for governments to design some regulations, such as tax and conservation zone. Nowadays, not only the government but the public society can also have access to know this management. Open and transparent groundwater application needs sufficient data. Based on that issue, this research aims to provide the geological and hydrogeological conditions of GWB, define the aquifer configurations, and determine the groundwater recharge-discharge zones and the type of GWB boundary on Karangkobar GWB. The methods applied to the study are 1) mapping the geological and hydrogeological condition; 2) reconstruction of subsurface stratigraphic condition; and 3) overlay four parameters of the recharge-discharge zone. The Karangkobar GWB consists of the unconfined and confined aquifer of High Plain Aquifer, where the groundwater flows from north and east heading southward and westward. Seven boundary types bounded the Karangkobar GWB. The map can also support the open and transparent water data application system, it will also ease the party that will conduct an assessment to design regulation regarding the groundwater management.
Analysis of Cavities Characteristics in the Semar - Kiskendo Caves System, Jonggrangan Karst Area, Kulon Progo, Indonesia
Authors: Agniy Romza Fauzan , Septianingrum Risma Sari , Adinugraha Ariel Seto , Alghozali Qodri , Aditya Bagas , Cahyadi Ahmad , Adji Tjahyo Nugroho
Published: October 2019

The Kiskendo Cave System is a system that has many benefits, including as a tourist site and water source. One of the systems in the upstream of Kiskendo Cave is the Semar-Kiskendo Caves system. This system is estimated to greatly affect the condition of the Kiskendo cave system because it is connected to the allogenic river which contributes to recharge from outside Jonggrangan Karst Area. The purpose of this research was 1) to find out the characteristics of the Semar Cave cavities and 2) to analyze the connectivity and characteristics of cavities in the Semar - Kiskendo Caves system. This research employed a survey method by mapping the cave to answer the first problem and conducting a tracer test of underground river stream to answer the second problem. The results showed that the Semar Cave cavity that could be mapped was 158.2 meters long, the total volume of the cave was 1,220.6 m3, and the average diameter of the cave cavity was 2.8 meters. The results of second study using the tracer test showed the connection between Semar Cave and the underground river in Kiskendo Cave, and the cavities had a characteristic of a single conduit which was sufficiently developed.
The Role of Institution Related to Conservation Area of Merbabu Mountain National Park in Boyolali District
Authors: Hartanto Bernadus Agus , Hidayat Jafron Wasiq , Prasetiyono Bambang Waluyo Hadi Eko
Published: October 2019

Conservation areas including Mount Merbabu National Park (MMNP) that have social, economic and ecological benefits both for the local and global environment need attention and support not only for MMNP office but also for the integration of the roles of parties related institutionally. The objective of the present study was to obtain the information about the involvement and integration of the roles of related institutions to support the conservation of the MMNP area in Boyolali District. The method is used literature review. The results shows that the role of various related institutions in MMNP conservation still varied. The local government, community institutions and other institutions do not have a continuous program in supporting conservation MMNP. Integration of related institutional roles in supporting the preservation of MMNP area through the compilation of conservation regulations that were followed up with the village regulation at buffer zone MMNP, Extension of MMNP conservation to all levels of society, especially at the school level, Integration of tourism development within and outside the MMNP area, Integration of community empowerment programs in and around the MMNP area, Mitigation of MMNP disturbances and disasters integratively.
The Changes of Mangrove Area in Pati Regency of the Year 2011 - 2015 and Their Impact Analysis: A Literature Review
Authors: Prihantoro Achmad Nur , Anggoro Sutrisno , Muhammad Fuad
Published: October 2019

Mangrove vegetation has a very complex function for human life now and in the future. Therefore protecting mangrove areas by preventing damage and reforesting in mangrove areas that have improved degradation must continue. The purpose of this study is to identify changes in mangrove areas for five years, as well as their impact. A literature review of previous research studies used to assess the impact of a decrease in the mangrove area, along with conservation strategies. The results showed that the degradation of mangroves for land conversion can result in decreased carbon stocks in sediments, changes in abiotic conditions in the media, a decrease in the number of fish catches, the occurrence of abrasion and a decrease infauna of the Mollusca group association. Integrated coastal management should pay attention to the sectoral dimension, dimensions of science and ecological dimensions.
Carbon Footprint from Settlement Activities: A Literature Review
Authors: Purwanto Agus , Syafrudin Syafrudin , Sunarsih Sunarsih
Published: October 2019

One of the causes of increasing greenhouse gases is the increase in CO2 emissions produced from both the industrial sector, transportation sector, and settlement sector. The settlement sector also contributes to CO2 emissions based on household activities. Research on carbon footprint from settlement activities is currently focusing on carbon footprints from household energy use both electricity and heat energy for cooking and have not taken into account the activities of vehicle fuel use, domestic waste, and water consumption. This paper aims to conduct a literature study on matters relating to the method of estimating the carbon footprint of settlement activities and influencing variables. The results of this study are a framework for estimating the more comprehensive carbon footprint of housing activities by adding private vehicle fuel consumption, waste generation, and water consumption in addition to the use of fuel for cooking and electricity use.
Effectiveness of Supervision of Spatial Planning Policies in the Karangsambung Geological Preserve Area
Authors: Kusyuniadi Indraya , Buchori Imam
Published: October 2019

The Karangsambung Geological Preserve area (KCAGK) is an area that has unique rocks and fossils, so it is nicknamed the "Black Box" process of the universe. Spatial policy in the form of a national, provincial and district Spatial Plan (RTRW) which establishes as a strategic area from the interests of environmental carrying capacity, as a consequence it is prohibited from all activities that change geological formation. Illegal mining activities are still a threat to the loss of protected rock diversity. The development of the industrial revolution era 4.0 has brought consequences and demands for increased accountability, transparency in public services by the government, thus bringing a paradigm shift and the role of supervision of spatial planning policies. This research will focus on aspects of supervision that are reviewed from the institutions and participation of the community. The study was carried out at the KCAGK location in Kebumen Regency, using quantitative methods through the information target was the community represented by village officials, community leaders and miners, while the institutions consisted of LIPI (Indonesian Institute of Science) and local government.
An Analysis of Bodri Watershed Governance System
Authors: Fauzia Husna , Setiadi Rukuh , Nugraha Satya Budi
Published: October 2019

Watershed management needs collaboration and program integration from all stakeholders including government and non-government institutions, as well as communities. Despite the existent of a number of regulatory frameworks, there are various problems in watershed management that need to be systematically diagnosed for future improvement. This paper focuses on Bodri Watershed, which stretches through three regencies (e.g. Temanggung, Semarang and Kendal Regencies) and has a vital role not only in the ecological but also socio-economic life of the surrounding communities. The paper aims to evaluate the current conditions of the watershed through governance lens. This paper employs Governance System Analysis (GSA) approach and mainly uses qualitative method for data collection. The paper finds that there is lack of coordination, integration, synergy and synchronization in the application of knowledge, connectivity and capacity for participation of related stakeholders to the management of the Bodri Watershed. This situation explains environmental problems and ecosystem damages in the Bodri Watershed area. These problems include massive land conversion, erosion, landslides, sedimentation, and flooding and drought in the rainy and dry seasons respectively.
Urbanization Consequences on Environmental Conditions in Indonesia
Authors: Sasana Hadi , Prakoso Jalu Aji , Setyaningsih Yuliani
Published: October 2019

Urbanization is still the main step taken by the community to get improved living conditions. Many developing countries have a high level of urbanization in cities due to the certainty of higher income levels. However, the problems that arise as a result of urbanization concern the environmental and social impacts of society. The purpose of this study is to show that the consequences of urbanization carried out by the community have a serious impact on environmental conditions. Urbanization, FDI, and fuel consumption affect environmental conditions as seen from the indicator of increasing carbon dioxide emissions (CO2) in Indonesia in 1990-2016.
Environmental Issues in Journalism Coverage at the Suara Merdeka Newspaper
Authors: Amirudin Amirudin
Published: October 2019

This article was written from the results of the study "Practices of Multicultural Journalism in Suara Merdeka Newspaper". This article reveals how environmental issues are packaged in the news through multicultural journalism conducted at Suara Merdeka Newspaper. This article is based on the assumption that news production always involves actors who have their imaginations, and a number of images are exchanged in the process of contestation and negotiation. The image becomes an entity that connects some interests which are outside media into the newspaper. Through the ethnographic method, this study reveals the dynamics of the relationship between actors that occur behind news writing. This study found that environmental issues have been successfully included as themes that meet the criteria for enforcing environmental purification and at the same time, criteria of the environment commodification. In terms of economics, this theme has relevance to the importance of economic growth driven through the use of the environment without destroying itself. While in criteria of environmental purification, bringing the issue of citizen rejection to the plan a cement plant is same as carrying out the mission of reducing activities of environmental exploitation.
Community Vulnerability and Capacity to Landslides in South Babakan Madang Subdistrict, Bogor Districts
Authors: Harist Muhammad Chaidir , Saraswati Ratna , Rustanto Andry
Published: October 2019

Many countries in the world have various kinds of problems, such as disasters. Indonesia is one of the countries with high area and population affected by landslides, such as in several regions in Indonesia, namely Bogor Districts. The affected population can be caused by the increasing number of residents and built-up areas, as well as the low level of public knowledge about landslides. The high population affected can describe the level of vulnerability and capacity that exists in the community, such as in South Babakan Madang Subdistrict. The density of the population and the built-up area which includes settlements, public facilities and community knowledge related to landslides that are different in 3 Countryside namely Bojong Koneng, Cijayanti, and Karang Tengah make the people in South Babakan Madang Subdistrict vulnerable to landslides. The modified scoring method with reference to Perka BNPB No. 02 of 2012 can be used to determine the level of vulnerability and capacity of the community. The results show that South Babakan Madang Subdistrict is dominated by moderate vulnerability with an index between 0.34 - 0.67. The capacity in the South Babakan Madang Subdistrict tends to be homogeneous in the low capacity class with an index < 0.34.