bluuebunny/crossref_metadata_2025 huggingface dataset:
Towards the studying of Kodorian Svan speech
Authors:   Arnold Chikobava Institute of Linguistics, Ivane Javakhishvili Tbilisi State University, Tbilisi,  Georgia, Chantladze Iza
Published: October 2021

In terms of general linguistics, the dialectal differentiation problem is particularly important on the late populated areas, especially if localization is in the mountainous region (Serebrenikov 1973: 135-139 (in Rus.)). In this respect, first of all, Kodorian and Cholurian dialects of Svan call the attention of linguists as well as ethnolinguists. The first is Svan of the Svans of Upper and Lower Bal population who moved from the Kodori Gorge (from Svaneti) and settled in the Enguri Gorge (in Apkhazia) a century ago, the second is the combination of Lower Svan dialects (Lashkhian-Lentekhian). I can only say this because the process of fundamental research of both speech is being carried out at the Arnold Chikobava Institution of Linguistics for several years under the financial support of the Rustaveli Foundation at the Ministry of Education and Science of Georgia. Prior to that, there were only separate theoretical expressions or the results of synchronous description of the empirical material in the professional literature fragmentary (Besarion Jorbenadze, Akaki Shanidze, Varlam Topuria, Maxime Kaldani, Mery Gujejiani, Mikheil Kurdiani, Tariel Putkaradze, Lamara Babluani…). The problem is quite serious and requires not only the linguistic approach but also the use of linguistic geography cartographic methods. After our scientific expeditions in the Kodori Gorge the militarypolitical battles (2008) complicated the situation - we have been taken away from the research object, so we have to work with the refugees who have been rooted out from their housing and who are scattered in the whole territory of Georgia. While we do not have deeply investigated ethnolinguistic research results of dialectal interferences, our request is to avoid the oral and written statements on the properties of the Kodorian Svan speech in separate articles. This study is an attempt to demonstrate the inter-merging of morphonological and lexicological occurrences of the Upper Svan dialects in the Kodorian dialect and its results.
On the Relation between Inference and Epistemics in the Verb Paradigm of the Kartvelian Languages
Authors:   Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia, Kurdadze Ramaz , Margiani Ketevan ,   Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia, Lomia Maia ,   Ivane Javakhishili Tbilisi State University, Tbilisi, Georgia
Published: October 2021

The verb paradigm of the Kartvelian languages enables us to draw interesting conclusions regarding the interrelationship between inference and epistemic modality. The paper analyzes the evidential perfect tenses common for all Kartvelian languages. The paper also focuses on certain organic imperfect evidential verb forms peculiar to the Megrelian and Svan languages. The issue of relation between inferential evidentiality and epistemics in the Kartvelian languages may be formulated as follows: a) Not every verb expressing inferential evidentiality is capable of expressing epistemic modality, b) All the verbs expressing epistemic modality are necessarily evidential.
Teaching Georgian as a second language: Modality and Tense (modal unda) 1
Authors:   Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia, Sharashenidze Nino
Published: October 2021

In the Georgian language, the verb paradigm is distributed among the forms of screeves (Shanidze). A screeve is a complex grammatical category which embraces the characteristics of tense, person, aspect, mood, permansive, resultative, perfect, evidentiality. The agglutinative nature of the language implies the existence of several grammatical meanings in one and the same verb form. The category of modality is expressed by means of adding modal elements to the verb form. The modal element expresses modal semantics, whereas the verb form bears the semantics of other grammatical categories. Thus, in Georgian, a modal construction embraces a combination of several grammatical peculiarities and semantics. The modal element is not usually found with all screeve forms. In order to express a modal content, different modal elements choose different screeves. The categories of tense and aspect are important features of the modal construction. The modal element unda is used with three screeves in Georgian: Present Subjunctive, Second Subjunctive and Second Resultative. Out of these, two are subjunctive mood forms, whereas the third one is the form of the indicative mood. However, as a result of weakening of the functions of the third subjunctive, the screeve of the second subjunctive has acquired numerous functions. One of such functions is to express modality in the past. Acquisition of modal constructions is an important part of language teaching. Modal constructions express the speaker’s attitude. In this regard, at a certain stage of language teaching these constructions are frequently addressed. It is very important for the learner to grasp the rules of formation of these constructions.
TEACHER TRAINING: EDUCATIONAL ACTIVITIES FOR PRE-SERVICE TEACHERS
Authors:   Vilnius University, Vilnius, Lithuania, Targamadze Vilija , Juskiene Vaiva ,   University of Applied sciences, Vilnius, Lithuania, Manjgaladze Mariam ,   Caucasus University, Tbilisi, Georgia
Published: October 2021

Teacher training has always been a challenge as teachers are prepared for work in the future, with a focus on developing the competencies required for a future person. Therefore, it is expedient to identify the competencies that he or she needs to develop. It is likely that those will be new directions of competence: creating new value, reconciling tensions and dilemmas, taking responsibility. In order to implement these or other competencies and literacies, it is necessary to model the study programmes of teacher training and educational activities used by teacher educators in pursuit of these goals. It is the suitability of educational activities used for the training of educators, working with the new generation, that is analysed in this article. In 2018, an empirical research was carried out on the suitability of the types of educational activities, as distinguished by D. Leclercq and M. Pournay (2005), used by the teacher educator in the preparation of pre-service teachers, with respect to the opinion of educational science researchers – experts. The research included nine researchers selected according to particular criteria, who were from three countries, namely Georgia, Latvia and Lithuania. There were three researchers from three different countries who assessed the suitability of educational activities by answering in writing to the questions submitted in the questionnaire. According to the experts, all types of educational activities may actually be suitable as long as they are targeted and properly designed to achieve the intended learning goals.
The Role of Tutor’s Feedback in Writing E-Course
Authors:   Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia, Shabashvili Giuli , Gochitashvili Ketevan ,   Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia
Published: October 2021

Paper aims to discuss the type, role and features of feedback of online writing course within the Georgian higher educational environment. Regulations of E-Learning Education is not set yet in the country. Therefore tutors are not experienced to run ecourses in general and the role/ importance of e-feedback is almost unfamiliar to them. The paper is preliminary research which aims to reveal the tutors’ attitudes/ readiness to apply e-feedback in their further activities. The research was conducted by following methods: Interviews: teachers were asked what do they think about importance of e-feedback and to which extent are they experienced in this regard. Questioners: teachers were given information about the main writing activities (Content, Structure, Analyse, Sources, Citation…) and main type of Feedback (Negative, Positive, Group, Corrective, Preventive, Peer, Evaluative) for each activity. Questioners contain the list of different feedback tools (e-mail, Forum, Private message, Audio/video-feedback…) as well. Teachers were given the opportunity to choose the most appropriate combination of feedback tools and types of each writing activities. Data analyse and results: The research reveals that instructors would prefer FtoF communication and traditional evaluation. As for the above mentioned combinations given in questionnaires, they were choosing simplest and not specific variations. Thus, they are less aware of the type of feedbacks and did not realize the possibilities and effectiveness. The paper studies the main reasons of it and based on both theoretical approaches and analysed data gives the recommendations to tutors. The results are generalized and prepared as a guidelines for the course designers and authors
Theoretical foundations for calculating bridges for endurance using the kinetic theory of durability of structural materials
Authors: Salamakhin Pavel M. , Lugovtsev Evgeny A.
Published: October 2021

The economically effective method for determining the unknown parameters of the dependence of the durability of structural materials on the level of acting constant stresses in them and their absolute temperature for various structural materials is proposed, taking into account the data established by Academician of the USSR Academy of Sciences S.N. Zhurkov. It does not require long-term testing of materials, but is based on the use of the results of short-term standard machine failure of two groups of standard samples of materials at two significantly different temperatures. When using these parameters and the Bailey integral criterion for summing up the losses in the durability of materials, it is possible to calculate the endurance of elements of road bridge structures from any structural materials and to determine the residual durability resource of the structure under the predicted subsequent mode of loading it with real temporary vertical loads.
Roll-over stability as a problem of high-rise buildings’ designing
Authors: Inozemtseva Olga V. , Inozemtsev Vyacheslav K. , Murtazina Gulsem R.
Published: October 2021

Roll-over stability of tall buildings under wind loads is considered. The nonlinear nature of the problem is taken into account, including geometric, physical, and structural non-linearity. The problem is solved on the base of a system of linearized incremental equations of structural mechanics that describes the behavior of a system tall building - foundation soil. Several methods are examined for solving nonlinear problems of roll-over stability, specifically: 1) deformation method of systems equilibrium states tracing; 2) method of linearization of nonlinear equations and systems equilibrium states tracing; 3) method of linearization of nonlinear physical relations of a systems with constructive, static, geometric nonlinearity; 4) method of linearization of nonlinear physical relations of a system with constructive nonlinearity based on nonlinear incremental structural mechanics; 5) method of the deformation process tracing for a physically nonlinear soil base, given the increase of discharge zones and constructive nonlinearity. Each of these methods is used to solve a model task. These tasks take into account roll-over stability of high structures under action of wind loads. In general, the problem of roll-over stability of a high object can be represented as repeatedly nonlinear one with various types of non-linearity. In this regard, in the practice of high-rise buildings designing, it is necessary to develop scientifically and methodically substantiated methods of assessing roll-over stability, considering non-linear factors. Taking these factors into account will make it possible to assess the roll-over stability of a high-rise object more accurate.
Innovation structures of very lean roller compacted concrete dams
Authors: Lyapichev Yury P.
Published: October 2021

Over the past 20 years, rolled compacted concrete (RCC) dams have continued to be built in many countries because of their technical and economic advantages over conventional dams of vibrating concrete and embankment dams. The aim of this study is the development of new structural and technological solutions in RCC dams in order to reduce the consumption of cement and expand their use on non-rock foundations, which will allow them to successfully compete with concrete face rockfill dams. The numerical analyses of static and seismic stress-strain state (SST) of gravitational dams in roller compacted very lean concrete dams have been made, as well as their stability, strength and cost have been assessed. For rock and dense sandy-gravel foundations the most economical is the concrete face rockfill dam and symmetrical RCC dam of very lean concrete with bases (0.5-0.7) of both slopes and outer zones of conventional concrete and central zone of rockfill strengthened by cement-ash mortar. Taking into account that the cost of diversion and spillway tunnels for very lean RCC dam will be less and the construction period - shorter than for the concrete face rockfill dam, it can be concluded that variant of symmetrical RCC dam of very lean concrete is the technically and economically effective. Symmetrical RCC dams of very lean concrete with 1V/(0.5-0.7)H slopes have more seismic resistance and technical and economic efficiency as compared with conventional gravitational RCC dams and other types of dams. These dams up to 200 m high can be built on rock foundations and up to 100 m high - on dense sandy gravel foundations.
The effect of story drift in a multi-story building under the influence of an earthquake
Authors: Sharapov Dmitriy A. , Gebre Tesfaldet H. , Ali Yusuf M.
Published: October 2021

This paper content is structure subjected sudden story drift as a result from earthquakes, forming hinges and eventually collapsing. The aim of this paper is to develop building thirty story building for seismic in Khartoum using finite element method (FEM) and the equivalent lateral force (ELF) procedure of American code ASCE 7-16. In current work the thirty-story reinforced concrete building was considered is to analyze the seismic behavior of the reinforced concrete structure to find the drift between the story by finding the maximum displacement from the program that causes the building to collapse, by choosing the shear wall as the support system to resist the lateral load and by looking to model the building inclined to the horizontal plane. Calculations were also made on the drift between the story to compare with the allowable drift. It is implemented in the Robot structural program - an ingenious program for designing and analyzing lateral (seismic) loads.
Experimental verification of new features of bearing operation under combined loading conditions
Authors: Kirilovskiy Valeriy V. , Belousov Yuri V.
Published: October 2021

Bearing units of lifting machines, products of construction, road, aviation, space and other branches of technology are very important structural elements, since the failure of even one bearing can cause the failure of the entire product. The results of experimental verification of the theoretical model of bearing operation under combined loading conditions are presented. The behavior under load of bearing units in the most general case can be represented by a sequence of five design schemes, expressed in the form of five statically indeterminate beams. The purpose of the experiments was to test this model under real loading conditions. The experiments were based on the analysis of the geometric shape of the curved elastic line, which the shaft of the bearing assembly acquires under load. The experimental results confirmed the validity of the model and showed that the previously generally accepted model of a two-support beam is not implemented. The conclusion is confirmed that in responsible lifting machines, as well as in responsible products of construction, road, aviation, space and other branches of technology, it is impractical to calculate bearings according to the traditional method, since an erroneous value of bearing durability can be obtained, overestimated from 28.37 to 26.663.9 times.
Experimental studies of the stress-strain state of reinforced concrete structures strengthened by prestressed basalt-composite rebar
Authors: Rubin Oleg D. , Lisichkin Sergey E. , Zyuzina Oksana V.
Published: October 2021

Relevance. In recent years, composite materials have become widespread in the construction of reinforced concrete structures for industrial, civil and transport structures. It is proposed to strengthen the reinforced concrete structures of hydraulic structures with prestressed basalt composite rebar. It took an experimental and theoretical substantiation of technical solutions to strengthen the reinforced concrete structures of hydraulic structures with prestressed basalt composite reinforcement. The aim of the work was to carry out a set of experimental and theoretical studies of the stress-strain state and internal forces in low-reinforced concrete structures of hydraulic structures reinforced with prestressed basalt composite rebar. Methods. Experimental studies of the stress-strain state and internal forces were carried out on the basis of low-reinforced concrete beam-type models with interblock construction joints, harden with prestressed basalt composite reinforcement in the stretched (compressed) zones of the models. Theoretical studies of the stress-strain state and internal forces were carried out on the basis of the theory of reinforced concrete and structural mechanics. Results. As a result of the research carried out on typical low-reinforced concrete structures of hydraulic structures with interblock construction joints, the main stages of the stress-strain state of hydraulic reinforced concrete structures were formulated. Based on the data of experimental and theoretical studies, taking into account the reinforcement with prestressed basalt composite rebar, as well as with prestressed clamps in the shear zone, a method was developed for calculating the strength of low-reinforced hydrotechnical reinforced concrete structures with interblock construction joints.
Eurasianism and Foreign Policy of Russia
Authors: Bazavluk S. V.
Published: October 2021

In order to determine the possibilities of wider application of the ideas of Eurasianism in the foreign policy of Russia, including the EAEU, but not limited to it, an analysis of various methods and approaches used for integration processes is carried out. At the same time, the current geopolitical situation and the factors of multi-vector approach in international relations are taken into account. It is also proposed to take in attention the role of identity in a broad sense as a political attraction. At the same time, various problems at the organizational, social, humanitarian and economic levels are also considered. The broad security factors that also play a role in the Eurasian integration are also taken into account. The relevance of this study is due not only to the implementation of strategic directions within the EAEU, but also to the general course towards multipolarity that Russia is pursuing. In addition, the crisis of liberal democracy in the West provides an additional opportunity for Russia to implement its own ideas and doctrines at the international level. The author believes that Eurasianism, including its classical version, can become one of the imperatives of Russia’s foreign policy.
The Union State in the Perception of Business: Are There Any Effects on Economic Integration?
Authors: Potaptseva E. V.
Published: October 2021

The Union State of Russia and Belarus is the longest-lasting regional integration project in the postSoviet space. The biggest volume of contradictions is accumulated in the area of economic integration, including the interaction between Russian and Belarusian enterprises. However, it is the corporate integration (“integration from below”) that creates prerequisites for achieving economic integration goals and objectives of the Union State. The aim of the research is to analyze the perception of the Union State by Russian regional enterprises as a project of economic integration of Russia and Belarus. The method of research is a semi-structured focused interview with representatives (owners, managers) of Sverdlovsk Region enterprises operating in Belarus. The article is structured as follows: the first part analyzes the economic integration of Russia and Belarus in the framework of the Union State. The second part is devoted to the description of the research design and characteristics of the sample. The third part answers the question whether the perception of Russian regional business has any effects on economic integration from the Union State. The analysis of regional enterprises’ perception of such integration project as the Union State shows that for the majority of respondents it is a political project that does not give significant economic benefits to Russian enterprises. Research results: a) most enterprises do not seek deeper economic integration of Russia and Belarus; b) Russian enterprises do not view the Union State as a single and economically beneficial space for doing business; c) Russian enterprises see the need to remove national barriers to facilitate interaction between Russian and Belarusian enterprises.
How to Build a Great Eurasian Partnership?
Authors: Glazyev S. Yu.
Published: October 2021

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Oppression or Protection: Reflecting on Medicine and Justice Through Narrative Medicine
Authors: Newman Haley , Diorio Caroline , Eison Daniel , Faust Haley , MacFarland Suzanne , Palmer Laura , Pradhan Madhura , Kersun Leslie
Published: October 2021

Early in the Coronavirus Disease 2019 pandemic, our medical center, like
many, halted in-person learning activities. The narrative medicine
sessions we planned for the pediatric hematology/oncology fellows were
no exception. At this time we also witnessed waves of civil unrest
fueled by systemic racism toward Americans of color. Amidst the
isolation, apprehension, and turmoil, we turned to narrative medicine.
To keep our participants safe and work around novel constraints, we
adapted the narrative medicine curriculum for virtual delivery.
Late-onset panuveitis in a Chinese girl with sporadic Blau syndrome: a case report
Authors: Ma Zicheng
Published: October 2021

The onset of ocular symptoms at age 18 is relatively rare in BS and the
eye lesions are usually serious.We reported a case of a 18 year-old
Chinese girl with late-onset mild panuveitis with sporadic Blau syndrome
.
Frequency and risk factors of acute and permanent femoral arterial occlusion in neonates with congenital heart disease who undergo ultrasound˗guided femoral arterial access
Authors: GOKDEMIR Mahmut , CINDIK Nimet
Published: October 2021

Background: In neonates, securing femoral arterial access is challenging
and time consuming even in experienced hands. Data on frequency and risk
factors of ALAP and PFAO are scarce in neonates with CHD. We
investigated frequency and risk factors of acute loss of the arterial
pulse (ALAP) and permanent femoral arterial occlusion (PFAO) in neonates
with congenital heart disease (CHD) underwent ultrasound˗guided femoral
arterial access (US˗GFAA). Methods: We divided the patients into groups
according to the presence of ALAP and PFAO. We obtained data related to
patient characteristics and access variables of US˗GFAA from our
database of pediatric cardiac catheterization between August 2017 and
May 2021. We used an echocardiography˗S6, 12˗MHz linear probe, 21˗gauge
needle, and a 0.018”guidewire for arterial access. A 4˗French sheath
(7cm) was placed in all patients. Results: US˗GFAA was obtained in
323(98.8%) of the 327 neonates. We identified ALAP in 130(40.2%)
patients and PFAO in 19(5.9%) patients. Median weight was 3.05(IQR:
2.80˗3.40) kg, first attempt success rate was 88.2% and median access
time was 46 sec (IQR: 23˗94). Logistic regression analysis identified
coarctation of the aorta (Odds ratio: 2.46; 95% CI: 1.30˗4.66; P=0.006)
as independent risk factor for ALAP, but did not identify any
independent risk factors for PFAO. Conclusion: This study showed that
coarctation of the aorta is an independent risk factor for ALAP in
neonates with CHD underwent US˗GFAA and placed a 4˗French sheath.
Although most cases of ALAP resolve in the early period, the frequency
of PFOA remains high despite effective treatment.
Interstitial flow upregulates matrix synthesis and attenuates NF-kB signaling in a novel perfusion bioreactor for articular cartilage tissue engineering
Authors: Abusharkh Haneen , Robertson Terreill , Mendenhall Juana , Gozen Bulent , Tingstad Edwin , Abu-Lael Nehal , Thiessen David , Wie Bernard Van
Published: October 2021

The present study is focused on designing an easy-to-use novel perfusion
system for articular cartilage (AC) tissue engineering and using it to
elucidate the mechanism by which interstitial shear upregulates matrix
synthesis by articular chondrocytes (AChs). Porous chitosan-agarose
(CHAG) scaffolds were synthesized, freeze-dried, and compared to bulk
agarose (AG) scaffolds. Both scaffold types were seeded with
osteoarthritic human AChs and cultured in a novel perfusion system for
one week with a shear-inducing medium flow velocity of 0.33 mm/s
corresponding to an average surficial shear of 0.4 mPa and a CHAG
interstitial shear of 40 mPa. While there were no statistical
differences in cell viability for perfusion vs. static cultures for
either scaffold type, CHAG scaffold cultures exhibited 3.3-fold higher
(p<0.005) cell viability compared to AG scaffold cultures.
Effects of combined superficial and interstitial perfusion for CHAG
showed 150- and 45-fold (p<0.0001) increases in total collagen
(COL) and 13- and 2.2-fold (p<0.001) increases in
glycosaminoglycans (GAGs) over AG’s scaffold non-perfusion and perfusion
cultures, respectively, and a 1.5-fold and 3.6-fold (p<0.005)
increase over non-perfusion CHAG cultures. Contrasting CHAG perfusion
and static cultures, chondrogenic gene comparisons showed a 3.5-fold
increase in collagen type II/type I (COL2A1/COL1A1) mRNA ratio
(p<0.05), and a 1.3-fold increase in aggrecan mRNA. Observed
effects are suggested to be the result of inhibiting the inflammatory
NF-κB signal transduction pathway as confirmed by a further study that
indicated a reduction by 3.2-fold (p<0.05) upon exposure to
perfusion. Our results demonstrate that the presence of pores plays a
critical role in improving cell viability and that interstitial flow
caused by medium perfusion through the porous scaffolds enhances the
expression of chondrogenic genes and ECM components through the
downregulation of NF-κB1.
Endobronchial Enchondroma: Unusual Bronchial Tumor
Authors: Kyoung Min Ryu , Myong Na-Hye , Kim Dohhyung
Published: October 2021

Bronchial chondromas are very rare pulmonary benign tumors. Despite
their rarity, clinicians should pay attention to the possibility of
endobronchial tumor in patients with unexplained respiratory symptoms.
Treatment modalities for complete excision of the tumor should be
initiated to prevent complications and malignant transformation based on
the individual tumor situation,
Intraventricular medulloblastoma misdiagnosed as gastrointestinal disease in a 4-years-old child
Authors: Amiji Insiyah , Jamnagerwalla Yusuf , Dossaji Zoheir , Hassanali Husseina , Amijee Huzeifa
Published: October 2021

Medulloblastoma is a highly malignant frequent paediatric brain tumor.
It can be misdiagnosed for other diseases when symptoms are non-specific
and neurological examination is normal during evaluation. Physicians
must be vigilant not only of suggestive neurological status but also of
non -specific symptoms that are persistence and recurring in nature.
Predictive value of indicator of CA125 combined with D-dimer (ICD) for lymph node metastasis in patients with ovarian cancer: A multicenter retrospective study
Authors: Shen Aiguo , Zhang Li , Guan Zongyu , Yin Yi , Ou Chaoyang , Qian Hongyan , Tang Min
Published: October 2021

Objective: To explore a new index that predict lymph node
metastasis(LNM) of ovarian cancer(OC). Design: A cross-sectional study
of two medical centers. Setting: Two medical centers from Nantong,
China. Sample: There were 447 patients included as the training set
meanwhile 284 patients were included in the validation set. Methods: A
total of 447 patients diagnosed with OC from January 2008 to June 2019
were included in this retrospective study as the training set. A total
of 284 patients were included in the validation set. The optimal cut-off
critical value of indicator CA125 combined with D-dimer(ICD) was
evaluated by the receiver operating characteristic curves(ROC), and the
maximum Youden index (sensitivity + specificity-1). Univariate and
multivariate analysis were used to evaluate ICD as a predictor of LNM in
OC. Main outcome measures: LNM burden. Results: According to ROC curve,
area under curve(AUC) of ICD (AUC=0.706, p<0.001) was
significantly larger than that of CA125 (AUC=0.671, p<0.001)
and D-dimer (AUC=0.562, p=0.022) alone. Multivariate analysis showed
that ICD (HR 2.651, 95% CI 1.273–5.520, p=0.009) was an independent
predictor of LNM rather than overall survival(OS) in OC. It has also
been verified in another medical center. Conclusions: ICD can be used to
screen and predict the development process of OC. ICD is an independent
predictor of LNM in ovarian cancers, which is helpful for clinicians to
draw up individual treatment plans. Funding Scientific Research Project
of “333 Project” in Jiangsu Province (BRA2019030). Nantong Science and
Technology Foundation grant (MS22019008). Keywords: OC, CA125, D-dimer,
ICD, NLM
Cell-derived and enzyme-based decellularized extracellular matrix exhibit compositional and structural differences that are relevant for its use as a biomaterial
Authors: Nellinger Svenja , Mrsic Ivana , Keller Silke , Heine Simon , Southan Alexander , Bach Monika , Volz Ann-Cathrin , Chassé Thomas , Kluger Petra
Published: October 2021

Due to its availability and minimal invasive harvesting human adipose
tissue-derived extracellular matrix (dECM) is often used as a
biomaterial in various tissue engineering and healthcare applications.
Next to dECM, cell-derived ECM (cdECM) can be generated by and isolated
from in vitro cultured cells. So far both types of ECM were investigated
extensively towards their application as (bio)material in tissue
engineering and healthcare. However, a systematic characterization and
comparison of soft tissue dECM and cdECM is still missing. In this
study, we characterized dECM from human adipose tissue, as well as cdECM
from human adipose-derived stem cells (ASCs), towards their molecular
composition, structural characteristics, and biological purity. The dECM
was found to exhibit higher levels of collagens and lower levels of
sulfated glycosaminoglycans (sGAGs) compared to cdECMs. Structural
characteristics revealed an immature state of the fibrous part of cdECM
samples. By the identified differences, we aim to support researchers in
the selection of a suitable ECM-based biomaterial for their specific
application and the interpretation of obtained results.
Shortcomings of telemedicine and importance of uninterrupted cancer care during the COVID-19 pandemic: A case report of advanced breast cancer in Fukushima, Japan
Authors: Ozaki Akihiko , Kaneda Yudai , Senoo Yuki , Wada Masahiro , Kurokawa Tomohiro , Sawano Toyoaki , Tsubokura Masaharu , Tanimoto Tetsuya , Kanemoto Yoshiaki , Ejiri Tomozo , Kanzaki Norio
Published: October 2021

We experienced an advanced breast cancer patient who failed to receive
diagnostic imaging despite regular video conferences with her physician
during the COVID-19 pandemic, resulting in delayed liver metastasis
detection. Recognizing shortcomings of telemedicine and collaboration
among medical institutions for uninterrupted cancer care is imperative
during the pandemic.
A Review of the Therapeutic Management of Multiple Ventricular Septal Defects
Authors: Chowdhury Ujjwal , Anderson Robert , Spicer Diane E. , Sankhyan Lakshmi , George Niwin , Pandey Niraj , Arvind Balaji , Goja Shikha , Malik Vishwas
Published: October 2021

Background and Aim: We showed in our anatomical review, ventricular
septal defects existing as multiple entities can be considered in terms
of three major subsets. We address here the diagnostic challenges,
associated anomalies, the role and techniques of surgical instead of
interventional closure, and the outcomes. including reinterventions, for
each subset. Methods: We reviewed 80 published investigations, noting
radiographic findings, and the results of clinical imaging elucidating
the location, number, size of septal defects, and associated anomalies,
and the effect of severe pulmonary hypertension. Results: Overall,
perioperative mortality for treatment of residual multiple defects has
been cited to be between zero and 14.2%, with morbidity estimated
between 6% to 13%. Perioperative mortality is twice as high for
perimembranous compared to muscular defects, with need for reoperation
is over four times higher. Perventricular hybrid approaches are useful
for closure of high anterior or apical defects. Overall, results have
been unsatisfactory. Pooled data reveals incidences between 2.8% and
45% for device-related adverse events. Currently, however, outcomes
cannot be assessed on the basis of the different anatomical sub-sets.
Conclusions: We have addressed the approaches, and the results, of
therapeutic treatment in terms of co-existing discrete defects, the
Swiss-cheese septum, and the arrangement in which a solitary apical
muscular defect gives the impression of multiple defects when viewed
from the right ventricular aspect. Treatment should vary according to
the specific combination of defects.
Respiratory syncytial virus (RSV) in pediatric influenza-like illness (ILI) cases in Lombardy, Northern Italy, during seven consecutive winter seasons (from 2014-2015 to 2020-2021)
Authors: Pellegrinelli Laura , Galli Cristina , Bubba Laura , Seiti Arlinda , Anselmi Giovanni , Primache Valeria , Signorini Lucia , Delbue Serena , Binda Sandro , Pariani Elena
Published: October 2021

INTRODUCTION. Respiratory syncytial virus (RSV) is the major cause of
lower respiratory tract illness in young children and can also cause
influenza-like illness (ILI). Here we investigated the epidemiological
features of RSV infection in pediatric ILI cases in Lombardy (a region
in Northern Italy accounting nearly 10-million inhabitants) from
2014-2015 to 2020-2021 winter seasons. MATERIAL AND METHODS. Data for
this study were retrieved and statistically analyzed from the database
of virological influenza surveillance of the regional reference
laboratory for Lombardy within the Italian influenza surveillance
network (InfluNet). RESULTS. RSV accounting for nearly 19% of pediatric
ILI with a risk of infection nearly 2-fold greater than that of
individuals ≥15 years. The RSV positivity rate increased to 28%
considering 0-5 years old children. Although in children ≤5 years the
risk of infection from influenza viruses resulted nearly 2-fold higher
than the risk of RSV infection, the age group 4-6 months and 7-12 months
showed 5-fold greater risk of infection from RSV than from influenza.
Children ≤5 years of age with presence of one or more comorbidities had
a nearly 5-fold greater risk of getting RSV infection than otherwise
healthy 0-5 years old children. DISCUSSION. The use of the ILI sentinel
surveillance allowed us to identify groups at higher risk of RSV and
influenza infection and to define the start, duration, timing and
intensity of the RSV and influenza community circulation, determining
thresholds based on historical data. This surveillance approach can be
implemented to assess the nearly real-time RSV circulation and impact.
ANALISIS MEKANISME PASAR (MENURUT PERSPEKTIF ISLAM DI KABUPATEN MANDAILING NATAL)
Authors: Siregar Erni Yusnita
Published: October 2021

Penelitian ini berjudul “Analisis Mekanisme Pasar (Menurut Perspektif Islam di Kabupaten Mandailing Natal)”. Adapun latar belakang penelitian ini adalah bahwa pasar merupakan elemen penting dalam ekonomi yang dapat mewujudkan kemaslahatan dan kesejahteraan hidup manusia. Namun pada kenyataanya pasar yang selama ini berkembang khususnya di Indonesia hanya tertuju pada upaya pemaksimalan untuk mencari keuntungan sebesar-besarnya semata dan cenderung terfokus pada kepentingan sepihak. Untuk itu peneliti melakukan studi pustaka terhadap mekanisme pasar menurut perspektif Islam khususnya di Kabupaten Mandailing Natal Agar mekanisme pasar dapat berjalan dengan baik dan memberikan mutual goodwill bagi para pelakunya, maka nilai – nilai moralitas mutlak ditegakkan. Metode yang digunakan adalah metode deskriptif analisis yaitu suatu metode yang meneliti status kelompok manusia, objek, suatu kondisi, suatu sistem pemikiran, ataupun suatu kelas peristiwa pada masa sekarang dengan tujuan membuat deskripsi, gambaran atau lukisan sistematis, faktual dan akurat mengenai fakta-fakta, sifat, serta hubungan antara fenomena yang diselidiki. Maka penelitian ini menghasilkan temuan bahwa: Mekanisme pasar yang sesuai dengan perpektif Islam yaitu mekanisme pasar yang sesuai dengan syariat Islam dengan menerapkan nilai syariah dalam prespektif mikro yang menekankan aspek kompetensi/ profesionalisme dan sikap amanah, sedangkan dalam prespektif makro  nilai-nilai syariahnya menekankan aspek distribusi, pelarangan riba dan kegiatan ekonomi yang tidak memberikan manfaat secara nyata kepada sistem perekonomian serta melibatkan pemerintah sebagai pengawas yang memberikan pengaturan maupun pelaksanaan kegiatan ekonomi yang tidak mampu dilaksanakan oleh masyarakat.
IMPLEMENTASI ANALISIS SWOT DALAM STRATEGI PEMASARAN BISNIS KULINER AYAM PANGGANG MADIUN
Authors: 28 Risalatin
Published: October 2021

Abstract This study examines the application of SWOT analysis in the Banjarejo grilled chicken restaurant business located in the city of Madiun. The results of this study indicate that the banjarejo grilled chicken restaurant has the courage to compete in a competitive competitive market. The threat from this business is relatively small because in the city of Madiun itself Banjarejo grilled chicken is a well-known culinary. With the marketing strategy of Banjarejo grilled chicken which uses two marketing strategies, namely offline marketing which is carried out by print promotion media and online with social media and in collaboration with go food.Keywords: Keywords: SWOT, marketing strategy, product.Abstrak Penelitian ini mengkaji tentang penerapan analisis SWOT dalam bisnis Rumah Makan Ayam Panggang Banjarejo yang terletak di kota Madiun. Hasil penelitian ini menyebutkan bahwa Rumah Makan Ayam Panggang Banjarejo sudah berani bersaing di pasar persaingan yang kompetitif. Ancaman dari bisnis ini pun relatif kecil karena di kota Madiun sendiri ayam panggang Banjarejo merupakan kuliner yang sudah terkenal. Dengan strategi pemasaran dari ayam panggang Banjarejo yang menggunakan dua strategi pemasaran yaitu pemasaran secara offline yang diilakukan dengan promosi di media cetak dan secara online dengan sosial media serta berkerja sama dengan go food.Kata Kunci: SWOT, strategi pemasaran, produk.
PENGARUH PROMOSI DAN LOKASI TERHADAP KEPUTUSAN PEMBELIAN RUMAH KPR PADA PT. DZAKIYAH MABRUKAH GEMILANG
Authors: Rinaldi Afdhol , Atifah Khairunnisa
Published: October 2021

Tujuan penelitian ini untuk mengetahui seberapa besar pengaruh promosi dan lokasi terhadap keputusan pembelian di PT. Dzakiyah Mabrukah Gemilang. Populasi dalam penelitian ini adalah konsumen yang melakukan pembelian rumah di PT. Dzakiyah Mabrukah Gemilang. Sampel yang digunakan adalah seluruh populasi sebanyak 43 responden. Metode pengumpulan data yang digunakan adalah observasi, kuisioner (angket), dan dokumentasi. Teknik analisa data adalah deskriptif dan kuantitatif. Metode analisis yang digunakan adalah Regesi Linier Berganda menggunakan program SPSS 23. Hasil penelitian uji t menunjukkan signifikan promosi (0,000) dan lokasi (0,002) lebih kecil dari 0,05, sehingga secara parsial berpengaruh signifikan terhadap keputusan pembelian. Hasil uji f menunjukkan signifikan 0,000 lebih kecil dari 0,05 sehingga secara simultan promosi dan lokasi berpengaruh signifikan terhadap keputusan pembelian. Hasil uji regresi linier berganda apabila promosi dan lokasi adalah konstan sama dengan nol maka nilai keputusan pembelian adalah 2,396, apabila penambahan 1 nilai pada promosi maka nilai keputusan pembelian meningkat menjadi 0,481 dianggap kosntan, dan apabila penambahan 1 nilai pada lokasi maka nilai keputusan pembelian meningkat menjadi 0,342 dianggap konstan. Hasil Koefisien Determinasi (R2) menunjukkan 64,4% bahwa keputusan pembelian dipengaruhi oleh promosi dan lokasi, 35,6% keputusan pembelian dipengaruhi oleh variabel lainnya yang tidak diteliti dalam penelitian ini.
THE ROLE OF INTERNATIONAL MONETARY FUND (IMF) IN ECONOMIC RECOVERY DURING ECONOMIC CRISIS OF INDONESIA
Authors: Farsia Lena
Published: October 2021

The International Monetary Fund (IMF) has a primary role in providing financial support to countries facing financial crises, such as the 1998 world financial crisis. The situation has brought an enormous impact on developing countries, particularly Indonesia. This paper explores the role of The IMF and maps out the problems related to the financial crisis and its impact on Indonesian political reforms. It will be done by compiling the milestones in chronological order from 1997 until 2017. It also aims to examine the lending policies of the International Monetary Fund, which brings a country like Indonesia becomes addicted and difficult to survive or improve in its economic development. There will be an understanding of how the actual process happens. It can be used as an instrument to assess whether the existence and role of the IMF in Indonesia have a better or harmful impact on the long-term economic development of Indonesia.   Keywords: The International Monetary Fund (IMF), Economic Development, Financial Crisis
FOREIGN CAPITAL INVESTMENT IN UPSTREAM OIL AND GAS: A CASE STUDY OF PASE WORKING AREA, ACEH PROVINCE, INDONESIA
Authors: Nurdin Nurdin , Amira Amira
Published: October 2021

This paper explores the management of the Pase Upstream Working Area of  oil and gas (MIGAS) by Triangle Pase Inc as a Foreign Direct Investment, which is not according to the Revenue Sharing Agreement signed by the parties and regulations Indonesia. The main obstacle in the implementation of Foreign Direct Investment in the Upstream MIGAS sector in Pase Working Area is the failure to establish the APGE as a Joint Venture Company that operated as a subsidiary company required by the Investment Law and Regulation of the Minister of Trade 08/2017. It has a severe impact on the Aceh government's income from the cooperation management of the Upstream MIGAS sector in the Pase Working Area. The Arbitration Award that BANI has granted, which rejected The PDPA lawsuit, has reduced and even eliminated the privilege of the Aceh Government in managing the Upstream MIGAS sector in the Pase Working Area as stipulated by Law Number 11 of 2006 and Aceh's MIGAS Government Regulation.  As a solution, the BPMA has ordered Triangle Pase Inc. to revise the legality of APGE to comply with the prevailing laws and regulations in Indonesia. Therefore, the BPMA, as the regulator, and The PDPA as the parties in the Upstream MIGAS management in the Pase Working Area and Commission III of the Aceh's House of Representative to immediately summon Triangle Pase Inc. to resolve the dispute between The PDPA and Triangle Pase Inc. The PDPA, as the losing party in the award granted by BANI, needs to take immediate legal steps to prevent the execution of the BANI's Arbitration AwardKeywords: BPMA; Pase Upstream Working Area; MIGAS; Aceh Province
CHILD MARRIAGE CONDITIONALITY AND ITS DISPENSATION IN MAHKAMAH SYAR’IYAH ACEH, INDONESIA
Authors: Jannah Raudhatul , Kadir M. Ya’kub Aiyub
Published: October 2021

This research aims to explain the policy regarding the conditionality and its dispensation of child marriage and to find out the effectiveness of the Law Number 16 Year 2019 Concerning the Amendment of Law Number 1 Year 1974 Concerning Marriage Law as well as the implementation of child marriage conditionality in Aceh by analysing Mahkamah Syar’iyah decisions. This research uses normative empirical legal research which mostly discusses on the Marriage Law and focuses on the norms regarding the conditionality and its dispensation of child marriage that is regulated under the Marriage Law and the implementation in Aceh. Keywords : Child Marriage, Children Rights, Legal problems, Mahkamah Syar’iyah.
ANTI-CORRUPTION IDEOLOGY IN HIGHER EDUCATION IN INDONESIA
Authors: Sulaiman Sulaiman
Published: October 2021

Anti-corruption ideology will get through deeply into the system of beliefs. Individuals with anti-corruption ideals are strengthened with their values, ideas, and norms, saying that corruption is atrocious. One of the potential opportunities for instilling the beliefs system is in higher education, where the education and teaching process and its recycling are taking place. The educational process at a higher education level is considered more established in understanding various levels of sciences and knowledge. Therefore, higher education has the greatest potency to ingrain anti-corruption ideals and encourage resistance against corrupt behavior. However, the potential is still debatable because educated persons conduct corruption, as it has been categorized as white-collar crime. Figures displayed by corruption statistics are outrageous. First, the rate of corruption targeted for investigation, being investigated, and punished is growing. Second, there is a tendency that the more a person developed, becomes more respected and educated, the more chances for the person to have a corrupted mindset. Hence, it can be concluded that education does not cause neglectfulness and powerlessness of someone to avoid corruption, but their intellectuality determines it. Keywords: Ideology; Epistemology; Anti-corruption; Higher education.
The Little Prince is an ecologist
Authors: Lortie Christopher J.
Published: October 2021

Stories shape the human experience. Fairy tales, fables, and historical stories from many peoples influence contemporary culture and science. The Little Prince is an excellent example of a short tale that highlights the relative importance of living with ecology and connectedness. It also clearly illuminates the absurdity that can emerge when one becomes isolated from even the simple processes associated with the functioning of other natural systems or from ecological interactions. This is one of many excellent stories that can be used in teaching science to frame theory for learners into different and larger novel contexts. This fairy tale provides morals for daily living too--tend to your garden, watch sunsets, and use nature to tame your absurd life and connect to others.  We use humour, stories, and current cultural memes from television and movies in many publications and/or their titles and in classroom lessons. Looking more broadly for tales and stories from different cultures and times promotes justice and openness.
Hantavirus in the peruvian jungle: a systematic review of series and cases reported
Authors: Saavedra Velasco Marcos , Oyarce Calderón Alvaro , Vargas Herrera Natalia , Pichardo Rodriguez Rafael , Moreno Arteaga Carlos M.
Published: October 2021

Hantavirosis is a zoonotic infection transmitted mainly by rodents. In Peru, a lethality of 40–60% is calculated in inhabitants of the Peruvian Amazon jungle, especially in Loreto. Despite this, this disease continues to be under-diagnosed despite the fact that it represents a serious problem for public health in Latin America. We present a sistematic revision of case reports and seris of cases of Hantavirus infection in the Peruvian jungle. The most important characteristic of the cases presented are mean age 25.7 years, predominance of females (5/6), clinical presentation of headache, myalgias, nausea and vomiting (6/6) and unfavorable evolution to acute respiratory to acute respiratory distress (ARDS), renal failure, septic shock and multiple organ failure in 3of the cases presented.