bluuebunny/crossref_metadata_2025 huggingface dataset:
Avaliação quali-quantitativa de Ficus benjamina Linn. na arborização viária de Itanhaém – SP
Authors: Tamara Ribeiro Botelho de Carvalho Maria  , Kendra Zamproni  , Daniela Biondi
Published: September 2021

Os inúmeros benefícios proporcionados pela arborização urbana fazem dela um importante elemento na estrutura das cidades. Estre as espécies comumente empregadas no paisagismo e na arborização urbana do Brasil estão as do gênero Ficus, entretanto poucas informações quanto ao comportamento da espécie no meio urbano são encontradas na literatura. Este trabalho teve por objetivo avaliar quantitativa e qualitativamente os indivíduos da espécie Ficus benjamina presentes na arborização viária do município de Itanhaém (SP). Para realizar o inventário, os indivíduos foram avaliados quanto a altura, CAP (posteriormente transformado em DAP), altura de bifurcação, área de copa e qualidade física e fitossanitária, qualidade de raiz e necessidades de manejo. Os indivíduos dessa espécie representam 16,8% da arborização do município, valor acima do recomendado. Quando avaliadas as características dendrométricas, verifica-se que os indivíduos dessa espécie apresentaram pequeno porte com altura média de 3,9 m, DAP médio de 0,18 m e área média de copa de 14,5 m². Na maioria dos indivíduos (42,9%), as condições físicas e fitossanitárias estavam ruins, cerca de 53,3% dos indivíduos apresentaram alguma superficialidade das raízes, e o índice de performance da espécie (0,71) demonstrou baixa adaptabilidade da espécie no município.
Conscientização dos usuários de bibliotecas por meio da educação patrimonial alicerçada em ferramentas visuais
Authors: Anna Claudia da Costa Flores  , Carlos Blaya Perez
Published: September 2021

Diante de problemas constatados no acervo da Biblioteca Setorial do Centro de Educação (BSCE) da Universidade Federal de Santa Maria (UFSM), como livros riscados, sem páginas, sujos e muitas vezes desaparecidos das estantes da biblioteca, verificou-se a necessidade de elaborar um programa de educação patrimonial alicerçado em ferramentas visuais com sinalização apropriada durante o desenvolvimento do projeto. Acredita-se que esse patrimônio somente será conservado por intermédio de um trabalho de conscientização do usuário. Consideraram-se a situação do acervo, a pesquisa sobre legislação referente, a educação patrimonial e a sinalização por imagens.
Formação do espaço social suburbano no Rio de Janeiro do início do século XX nas páginas do jornal O Subúrbio
Authors: Luciana Verônica Silva Moreira
Published: September 2021

Os anos iniciais do século XX foram, para a cidade do Rio de Janeiro, um período de grandes transformações no espaço urbano, ocasionadas sobretudo pelo crescimento populacional do município. A caminhada em direção aos subúrbios da zona norte teve início no século XIX e se intensificou com a construção da estrada de ferro Dom Pedro II em meados do século. O processo de urbanização e saneamento de áreas ao longo das estradas de ferro suburbanas e a grande destruição dos cortiços das regiões centrais contribuíram para o alargamento do espaço geográfico da cidade e o aumento da população residente nos subúrbios. Este artigo analisa a dinâmica social que envolve o processo de formação das sociedades suburbanas durante o início do século XX para compreender sua constituição interna inicial, as relações sociais estabelecidas e os desafios que se faziam presentes ao morador do subúrbio enquanto habitante da cidade em transformação.
Arte contemporânea em movimento: grafite e valor mutante da estética
Authors: Rildson Alves dos Santos Grunow
Published: September 2021

O presente ensaio tem como finalidade discutir o processo de atribuição de valor da expressão artística nos desdobramentos da cultura na contemporaneidade. Tal cultura se dissemina de forma não homogênea, mas contínua, em várias regiões sob influência do Ocidente, o que possibilita encontrar no grafite a versão artística desse momento, pelo menos no que se refere às Artes Visuais, pois pode ser facilmente encontrado de modo simultâneo em várias partes do mundo abordando temáticas similares. A apropriação e a reconfiguração de tais valores pela ideologia mercadológica, especialmente quanto a essa forma de arte, são o objeto deste estudo.
Surgical correction of vertical maxillary excess associated with mandibular self-rotation
Authors: Michelle Nascimento Meger  , Fernanda Tiboni  , Felipe Silvério dos Santos  , Thalyta Verbicaro  , Tatiana Miranda Deliberador  , Rafaela Scariot  , Gleisse Wantowski
Published: September 2021

The Class I skeletal deformity associated with vertical maxillary excess is a rare condition reported in the literature. Surgical impaction allows the correction of the long face and gummy smile. Objective: This case report aimed to evaluate the positioning of the condyle after Le Fort I osteotomy associated with mandibular selfrotation. Case report: The patient underwent orthognathic surgery for the correction of maxillary vertical excess. Tomography studies were performed to evaluate the initial and final position of the condyle. The patient improved mastication, breathing and phonetics, with esthetic benefit. Conclusion: After the Le Fort I osteotomy and mandibular self-rotation, the condyle remained stable occupying a new anterior-superior position in the glenoid fossa and patient’s TMJ remained asymptomatic after 9 months of postoperative follow-up.
Association of the profile of individuals with cleft lip/palate with the beginning of orthopedic/ orthodontic treatment
Authors: Madiana Magalhães Moreira  , Pedro Diniz Rebouças  , Maria Lúcia Bonfim Chagas  , Luan Cartaxo Félix  , Paulo Goberlânio de Barros Silva  , Mário Rogério Lima Mota
Published: September 2021

Cleft lip and palate (CLP) is the most frequent congenital malformation among the anomalies of the head and neck. The orthopedic/orthodontic treatment is included in the rehabilitation of these individuals, however there is no consensus in the literature regarding the ideal time for its beginning. Objective: To verify and characterize the profile of individuals with CLP treated at a reference hospital of the northeast of Brazil from 1998 to 2013 and its association with the beginning of the orthopedic/ orthodontic treatment. Material and methods: Through direct observation of medical records, panoramic radiograph, and study casts of 323 individuals, data regarding sex, cleft type, origin and age of beginning of the orthopedic/orthodontic treatment were surveyed and analyzed using the chi-square test, considering a 5% level of significance. Results: Most of the individuals had transforamen and the unilateral cleft was the most prevalent (p<0.05). Females were statistically more affected by post-foramen cleft and males by trans-foramen cleft (p><0.05). Most individuals with trans-foramen cleft and post-foramen cleft started the orthopedic/ orthodontic treatment between 8 and 12 years old (p><0.05). No statistically significant differences occurred relating the beginning><0.05). Females were statistically more affected by post-foramen cleft and males by trans-foramen cleft (p<0.05). Most individuals with trans-foramen cleft and post-foramen cleft started the orthopedic/ orthodontic treatment between 8 and 12 years old (p<0.05). No statistically significant differences occurred relating the beginning> <0.05). No statistically significant differences occurred relating the beginning of the orthopedic/orthodontic treatment with geographic origin and sex of, although most of them have started treatment at late mixed dentition. Conclusion: Regardless of gender, origin, or cleft type, most patients started orthopedic treatment up to 12 years-old, an age considered ideal by most protocols. Unilateral and trans-foramen cleft were the most prevalent cleft types. post-foramen cleft affected more females, while trans-foramen cleft affected more males.
Tooth alveolus repositioning of impacted canine – case report
Authors: Vitor Hugo Candido Ferreira  , Guilherme Strujak  , João Luiz Carlini
Published: September 2021

Impacted teeth with complete root formation in adult patients is challenging for both the surgeon and orthodontist. Described for more than 40 years and still rarely used, the technique of tooth alveolus repositioning has excellent treatment results in these cases. Objective: To report the case of a impacted canine in an adult patient, not responsive to standard surgical orthodontic traction, managed through the technique of tooth alveolus repositioning. Case report: Male patient, 28 years old, with presence of tooth #23 impacted and with no success to standard surgical orthodontic traction. To return the tooth in position and function the treatment performed was repositioning the alveolar block. After two years of follow-up the tooth stays in the ideal position, without root resorption and with pulp vitality. Conclusion: The tooth alveolus repositioning proved to be a good treatment option, restoring function and esthetics and reaching the expectations of both the patient and professionals.
Treatment of peri-implantitis with surface decontamination and particulate bone graft in a smoker patient
Authors: Marina Samara Baechtold  , Aline Rocha Miquelissa  , Viviane Rozeira Crivellaro  , Rafaela Scariot  , João César Zielak  , Tatiana Miranda Deliberador
Published: September 2021

With the increase of implant-supported rehabilitation, the cases of patients with peri-implantitis become more frequent. Objective: To report the treatment of peri-implantitis by associating techniques of surface decontamination and particulate bone graft. Case report: The treatment was carried through curettage of the granulation tissue, mechanical bone decontamination with bicarbonate jet, chemical decontamination with tetracycline solution, and particulate graft in the place of the bone defect. Conclusion: After 45 postoperative days, the peri-implant tissues were health without inflammation. After 6 postoperative months, the bone defect was repaired.
Split crest technique: a solution for atrophic anterior maxilla – case report
Authors: Vanessa Marques Delai  , Leonardo Brunet Savaris  , Fábio Furquim  , Paulo Roberto Camati  , Aline Monise Sebastiani  , Tatiana Miranda Deliberador  , Rafaela Scariot  , João César Zielak
Published: September 2021

The rehabilitation of atrophic anterior maxilla can be done by different techniques. Among the procedures for bone augmentation, we can use block grafting, guided bone regeneration, and split crest technique (SCT). SCT consists in bone crest osteotomy, followed by manual/mechanical expansion up to the splitting of the buccal plate from the lingual/palatal plate through greenstick fracture. SCT advantage is the possibility of simultaneously installing a dental implant. However, SCT planning should consider the remaining bone width and the the flap type to obtain success. Objective: To report a case of implant-supported rehabilitation of an atrophic anterior maxilla using the split crest technique with insertion of 4 immediate implants, showing the effectiveness of the technique.
Use of dental care services and related factors in students with special health care needs in a rehabilitation and education center
Authors: Ivam Freire da Silva Júnior  , Vanessa Müller Stüermer  , Andreia Drawanz Hartwig  , Lisandrea Rocha Scharsdosim  , Marina Sousa Azevedo
Published: September 2021

People with special health care needs (SHCN) have a higher risk of contracting certain oral diseases, such as dental cavities and gingivitis, and a limited use of dental care services can significantly affect these risks. Objective: To assess the use of dental care services and related factors in students with SHCN. Materials and methods: This cross-sectional study included subjects from a rehabilitation and education center. The guardians were asked about whether the students already made a dental appointment and about the last time they had visited their dentist. The students were examined for dental cavities. Fisher’s exact test for the association between the outcome and independent variables was employed. Results: The study sample comprised 51 guardians. Forty-seven students had already visited their dentist at least once, and 68% underwent a dental exam within the past year. A recent use of dental service (1 year or less) was more prevalent among female subjects, which did not present a history of dental cavities and about whose caregivers already had received oral health information. Conclusion: Most of the participants already had visited their dentist and regularly use dental services. Caregivers should be encouraged to make regular dentist appointments for SHCN subjects, especially for those who already have oral problems, are male, and whose families have never received oral health information.
Relationship between mandibular incisive canal and mental foramen using cone-beam computed tomography in a selected Brazilian Amazon population
Authors: Cláudia Gemaque Marinho  , Pedro Luiz de Carvalho  , Edson Marcos Leal Soares Ramos  , Fabricio Mesquita Tuji  , Nicolau Conte Neto
Published: September 2021

The mandibular canal is an anatomic structure that extends bilaterally from the mandibular foramen to the mental foramen. Objective: To identify the presence, extension, and length of the mandibular incisive canal with a cone-beam computed tomography, and to determine correlations with the positioning of the mental foramen and mandibular canal in a selected Brazilian Amazon population. Material and methods: The measurements of the incisive canal that ends at the mandible’s lower buccal and lingual border, at its initial and terminal portions, were obtained from 95 odontological examinations using cone-beam computed tomography. These measurements were compared with the measurements of the distance between the mandibular canal ending at the same cortices in 2 distinct regions at the mental foramen region. Pearson’s correlation test was used to establish a relationship between these measurements. Results: The mandibular incisive canal’s bilateral identification mean age was of 44.29 ± 11.04 y and the mean length was 10.38 ± 4.01 mm. Moderate correlations were found between the measurements of the mandibular incisive canal, mental foramen, and mandibular canal. Conclusion: The mandibular incisive canal can reach the region of the median line, and it did not present differences between the genders or for the length and distance of the mandibular incisive canal to the cortices ending at the mandible base.
Índice de sucesso do tratamento endodôntico dos pacientes atendidos no Centro de Especialidades Odontológicas
Authors: Fernanda Olivete Bragante  , Carlos Roberto Botelho Filho  , Ana Carolina da Silva  , Bruno Marques da Silva  , Luiz Fernando Fariniuk  , Denise Piotto Leonardi  , Flávia Sens Fagundes Tomazinho
Published: September 2021

Os Centros de Especialidades Odontológicas (CEOs) dão continuidade ao tratamento realizado pela rede de atenção básica, ofertando serviços odontológicos especializados. Objetivo: Avaliar a qualidade técnica e o índice de sucesso dos tratamentos endodônticos realizados no CEO-UP no período de abril a dezembro de 2016. Material e métodos: No período de interesse da pesquisa foram realizados 187 tratamentos endodônticos em 170 pacientes. Avaliaram-se os participantes da pesquisa por meio dos dados contidos no prontuário, de exames clínicos e radiográficos. Os dentes tratados endodonticamente foram examinados por um especialista em Endodontia, um ano após a conclusão do tratamento, que avaliou a condição clínica e comparou e analisou as radiografias realizadas no fim do tratamento com as radiografias atuais. Os dados coletados foram apresentados de forma descritiva mediante números absolutos e percentuais. Resultados: Compareceram à avaliação 53 pacientes, totalizando 59 dentes tratados. Destes, 98% apresentavam correta adaptação do material obturador e 84% estavam com o limite apical da obturação adequado. Quanto à condição do dente, 71% estavam restaurados com material definitivo. Oitenta por cento dos dentes não apresentavam lesão periapical, e em 17% a lesão havia diminuído. Conclusão: Os tratamentos endodônticos realizados no CEO-UP possuem uma adequada qualidade técnica, resultando no sucesso do tratamento endodôntico feito por esse serviço.
Assessment of the preferred restorative material – composite resin or ceramic – for anterior teeth restoration
Authors: Fernanda Haverroth Schünemann  , Jonas Alberto Valmorbida  , Jussara Karina Bernardon
Published: September 2021

To evaluate the perception of clinicians and undergraduate students concerning their preferences and experience in using composite resin and ceramic veneers to restore anterior teeth restorations. Material and methods: 60 participants including clinicians (n=30) and undergraduate students (n=30) volunteered for this study. The study consisted of two parts. Firstly, the participant answered questions about their use and possible failure of ceramic or composite resin for anterior teeth. In the second part, participants analyzed 3 photographs of the anterior smile and reported on the presence of healthy teeth or restored teeth, with composite resin or ceramic veneers. Results: For both groups, composite resin was frequently used over ceramic and the most important reported factor in this decision choice was the cost factor. Both groups presented a failure percentage higher than 50% for composite resin, and this percentage was higher for undergraduate students. In the visual analysis of the photographs, none of the participants identified all the restorations correctly. Conclusion: Composite resin is the most common material of choice for clinicians and undergraduate students. Distinguishing natural teeth from restored teeth has become increasingly difficult, despite the restorative material (composite resin or ceramic) used.
Análise radiográfica das aberturas endodônticas de dentes de pacientes referenciados a um Centro de Especialidades Odontológicas
Authors: Bianca Mara Zakalusne do Nascimento  , Cristiano Zortéa  , Monique Marchiori  , Kauhanna Vianna de Oliveira  , Flávia Sens Fagundes Tomazinho  , Vanessa Cavassin Klamas  , Eduardo Pizzatto  , Marilisa Carneiro Leão Gabardo
Published: September 2021

A abertura coronária é a primeira etapa do tratamento endodôntico e visa ao acesso direto aos canais radiculares. Objetivo: Avaliar as aberturas endodônticas de dentes de pacientes referenciados ao Centro de Especialidades Odontológicas (CEO) Positivo, na cidade de Curitiba (PR), por análise radiográfica. Material e métodos: Um total de 226 radiografias periapicais tomadas previamente ao atendimento no CEO, de agosto de 2015 a agosto de 2017, foi analisado. Três examinadores treinados e calibrados verificaram os seguintes critérios: região da cavidade bucal, cárie remanescente, remoção do teto da câmara pulpar, desgaste compensatório mesiodistal, iatrogenia (sugestiva) e restauração temporária. Os dados foram tabulados e analisados quanto à distribuição, seguida de análise bivariada (Teste Exato de Fisher) com significância de 5%. Resultados: A região posterior prevaleceu em 70,3% da amostra. Constataram-se cárie remanescente em 14,2%, remoção insuficiente do teto em 25,2%, iatrogenia em 31,4% e altura inadequada da restauração temporária em 11,5% dos casos. Nos dentes posteriores, o desgaste compensatório mesiodistal insuficiente foi identificado em 35,4% dos exames. A análise bivariada não revelou diferença significativa quando verificada a variável região da cavidade bucal em relação a presença de cárie (p = 0,393), teto remanescente (p = 0,056) e presença de iatrogenia (p = 0,304). Conclusão: Há falhas relevantes nas aberturas endodônticas recebidas no CEO, o que indica a necessidade de treinamento profissional na atenção primária.
Le Fort II osteotomy for medium-face fracture sequel correction
Authors: Thalyta Verbicaro  , Aline Monise Sebastiani  , Jennifer Tsi Gerber  , Bruno Viezzer Fernandes  , João Cesar Zielak  , Rafaela Scariot  , Leandro Eduardo Klüppel
Published: September 2021

Fractures should be treated by a multi-professional team to minimize sequels. The surgery aims to establish a good maxillary, mandibular relationship to improve mastication and phonetics and may benefit esthetics. Objective: to report the surgical procedure with Le Fort II osteotomy for correction of class III dentofacial deformity and the nasomaxillary deficiency caused by trauma. Case report: Patient victim of aggression for 10 years suffered a Le Fort II fracture. The fracture was not treated and the patient developed a severe anteroposterior defect of the nasomaxillary complex and Class III occlusion. The surgery for correcting deformities was performed with the bicoronal, lower eyelid and intraoral accesses. Le Fort II pyramidal osteotomy was performed with a piezoelectric motor to advance 7 mm the nasomaxillary complex. Conclusion: Le Fort II osteotomy is considered satisfactory for advancing the nasomaxillary complex, improving the patient´s psychosocial function and development.
Fratura de agulha de sutura encontrada em espaço parafaríngeo
Authors: Dayane Jaqueline Gross  , Luciana Dorochenko Martins  , Jéssica Daniela Andreis  , Marcelo Carlos Bortoluzzi  , Ramon César Godoy Gonçalves
Published: September 2021

Das especialidades, a cirurgia bucomaxilofacial é aquela em que o profissional está mais exposto a acidentes e complicações. Assim, uma vez indicada a cirurgia, é importante que se faça um planejamento cirúrgico detalhado baseado no exame físico e em exames de imagem, a fim de evitar iatrogenias. Objetivo: Relatar um caso atípico e raro de fratura de agulha de sutura após a realização de sutura em cirurgia oral menor. Relato de caso: Paciente do gênero feminino, com a presença de uma agulha de sutura em espaço parafaríngeo, removida por procedimento cirúrgico sob anestesia geral. Conclusão: A paciente evolui bem, sem complicações. Se ocorrer uma fratura, complicações secundárias podem ser evitadas enviando prontamente o paciente para um hospital especializado, para evitar o movimento de fragmentos em regiões mais profundos do tecido.
Atividade antimicrobiana de extratos etanólicos de Banisteriopsis anisandra (Malpighiaceae) e interações medicamentosas
Authors: Igor Valdivia Ferreira  , Maria Cristina Mendes-Costa
Published: September 2021

A planta Banisteriopsis anisandra A. Juss é uma espécie medicinal pouco conhecida e estudada, mas já demonstrou potencial para utilização na odontologia. Objetivo: Avaliar a atividade antimicrobiana de B. anisandra e o potencial para interações medicamentosas com fármacos relacionados à saúde bucal. Material e métodos: Foi obtido o extrato etanólico bruto das folhas de B. anisandra, e diluições em série foram testadas contra Candida albicans (ATCC 10231), Streptococcus mutans (ATCC 25175), Streptococcus salivarius (ATCC 7073) e Staphylococcus aureus (ATCC 6538). Como controle positivo foram utilizados os antibióticos ampicilina (10 µg/ml), amoxilina (10 µg/ml) e penicilina (30 µg/ml), para as cepas bacterianas; e o antifúngico cetoconazol (2 mg/ml), para a levedura. Compararam-se a eficiência e a sensibilidade do método de difusão em meio sólido e do método de difusão em meio líquido, e foi determinada a concentração inibitória mínima (CIM), assim como foram avaliadas as interações medicamentosas dos extratos com os antibióticos. Resultados: O método de microdiluição em caldo mostrou-se mais sensível que o método de difusão em disco, sendo, portanto, mais confiável, além de usar menos quantidade de material. Houve interação medicamentosa positiva dos extratos com os antibióticos e com o cetoconazol nas concentrações de 1:2 para o extrato. A bactéria S. aureus e a levedura C. albicans mostraram-se sensíveis ao extrato da planta na diluição 1:1 nos testes de difusão em disco, e o antibiótico penicilina não se revelou eficaz em nenhuma das bactérias testadas. Conclusão: O extrato etanólico de B. anisandra tem potencial antimicrobiano e interação medicamentosa com fármacos relacionados à saúde bucal. Existem raros estudos sobre as propriedades farmacológicas de B. anisandra, e os resultados são os primeiros relatos sobre sua atividade antimicrobiana em associação com antibióticos e antifúngicos.
Reposicionamento dental imediato em segundo molar inferior: relato de caso
Authors: Mateus Barros Cavalcante  , Caroline Brígida Sá Rocha  , Larissa Gabriele Batista Gomes  , Caio Pimenteira Uchôa  , Rômulo Augusto de Paiva Macêdo  , Marcelo Soares dos Santos  , Emanuel Dias de Oliveira e Silva
Published: September 2021

Dentes inclusos podem ser definidos como os que permanecem sobre tecido duro ou mole após cessados os estímulos eruptivos fisiológicos. A verticalização cirúrgica é um manejo do dente com intuito de reposicioná-lo para que ele possa cumprir sua função dentro da boca. Essa técnica deve ser utilizada sempre que o elemento dentário em questão apresente condições de saúde ou sem grandes destruições, o que possibilita ser mantido. Devese lançar mão dessa cirurgia principalmente em pacientes jovens, para permitir uma melhor saúde estomatognática, diminuindo a necessidade de reabilitação protética precoce. Objetivo: Apresentar a vantagem do reposicionamento imediato do dente. Relato de caso: Paciente jovem, 21 anos, do sexo masculino, encontrava-se com o terceiro e segundo molares inclusos, com o último prejudicando o dente adjacente. O reposicionamento mediante verticalização cirúrgica permitiu o rápido retorno funcional do elemento dentário, assim como a sua permanência dentro da cavidade oral. Após a cirurgia, o paciente foi encaminhado para tratamento endodôntico do elemento. Conclusão: A verticalização cirúrgica proporcionou o reposicionamento dental imediato, mostrando ser uma técnica cirúrgica rápida e de fácil manuseio, com bom prognóstico e baixo índice de complicações.
Effect of heat on the hardness of glass carbomer cement used in atraumatic restorative treatment
Authors: Natascha Douat Hannegraf  , Maria Eduarda Schultze Mendes Ribeiro  , Célia Maria Condeixa de França Lopes  , Flares Baratto-Filho
Published: September 2021

This study aimed to evaluate the effect of heat treatment on the microhardness of two glass ionomer cements: EQUIA Forte (GC Corporation) and GCP Glass Fill (GCPDental). Material and methods: Twenty specimens of the two glass ionomer cements were prepared following the manufacturer’s instructions, and 10 specimens of each material received heat treatment with a light curing unit (Carbo LED lamp, GCP-Dental). After seven days of storage in distilled water at room temperature (23°C), the 40 specimens were submitted for Vickers microhardness test (microhardness HMV 2T). Five indentations were performed on each specimen with a load of 100g, with a 10 second penetration time. Results: For both materials, the average microhardness value were higher in the groups that did not undergo heat treatment, the group presenting with the highest microhardness value was EQUIA Forte (GC Corporation) without heat treatment (125.3), and the lowest value was found for GCP Glass Fill (GCP-Dental) with heat treatment (72.9). Conclusion: The heat treatment had no influence on the microhardness of the glass ionomer cements tested.
Expectativa e percepção da experiência do paciente ante o tratamento endodôntico
Authors: Carlla Sloane Alberton  , Bruna Isabel Nunes Vieira da Costa  , Carlos Roberto Botelho Filho  , Mariana de Almeida Barbosa  , Marilisa Carneiro Leão Gabardo  , Flávia Sens Fagundes Tomazinho
Published: September 2021

Os pacientes que necessitam de tratamento endodôntico geralmente têm uma expectativa negativa em relação a esse procedimento. Objetivo: Avaliar a expectativa e a percepção de pacientes que realizaram o tratamento endodôntico na clínica de especialização em Endodontia ou no Centro de Especialidades Odontológicas da Universidade Positivo. Material e métodos: A amostra de conveniência contou com 123 pacientes, que foram atendidos no período de setembro de 2016 a outubro de 2017. Eles responderam a um questionário com perguntas referentes a gênero, idade, expectativas quanto ao tratamento endodôntico, presença de dor e também questões relacionadas à experiência durante e após a realização do tratamento endodôntico, bem como ao atendimento prestado. Os dados foram tabulados e expressos em frequência e porcentagem. Depois utilizou-se o teste de Qui-quadrado, por meio do programa SPSS, versão 21.0. Resultados: A maioria dos pacientes eram mulheres, entre 41 e 50 anos, que já haviam realizado tratamento endodôntico anteriormente. A ausência de dor foi relatada por 76% dos pacientes, e 50% não tiveram medo durante o tratamento endodôntico. A anestesia, as agulhas e limas representaram os fatores que mais causaram medo nos pacientes. Para 28,5% a experiência foi como imaginavam; para 70,7% foi melhor do que pensavam. Dos respondentes, 93,5% consideraram o atendimento ótimo. Conclusão: O sentimento de medo antes do tratamento endodôntico foi relevante e agravado pela visualização de materiais e instrumentais. Entretanto a ausência de dor durante a intervenção favoreceu positivamente a percepção pós-operatória, com diminuição do relato de medo entre os pacientes.
Efeito de clorexidina em gel ou dentifrício nos níveis salivares de estreptococos do grupo mutans em crianças do distrito do Saí (São Francisco do Sul, SC, Brasil)
Authors: Débora Luiza ZUCCO  , Bruna ROSSI  , Célia Maria Condeixa de França LOPES  , Paulo Henrique Condeixa de FRANÇA  , Edward Werner SCHUBERT
Published: September 2021

Introdução: A cárie dentária é a doença mais prevalente no ser humano, sendo caracterizada pela destruição progressiva dos dentes afetados. Para que ocorra são necessários um hospedeiro susceptível, uma microbiota bucal cariogênica, principalmente os estreptococos do grupo mutans (EGM), e um substrato adequado, os quais devem estar presentes por um período de tempo suficiente. Dos agentes antimicrobianos disponíveis para uso dentário, a clorexidina é um dos mais eficazes em reduzir a proporção de alguns microrganismos, especialmente os EGMs. Objetivo: O objetivo do estudo foi comparar a eficácia de duas formas de clorexidina a 1% (gel e dentifrício) aplicadas em escolares, sob escovação supervisionada, fora do ambiente de consultório odontológico, na redução dos níveis salivares de EGM. Material e métodos: A amostra foi composta de 30 crianças e separada em dois grupos: grupo A (dentifrício) e grupo B (gel). As escovações foram realizadas uma vez por semana durante quatro semanas consecutivas. Anteriormente à primeira escovação e 30 minutos após a escovação da quarta semana, realizou-se a coleta salivar. Foram preparadas diluições seriadas decimais das amostras de saliva até a diluição 10-3. Amostras das diluições foram semeadas em meio de cultivo ágar Mitis Salivarius bacitracina sacarose (MSBS), seletivo ao crescimento de EGM. Resultados e conclusão: Após contagem das unidades formadoras de colônia de EGM, foi realizada a média das quadruplicatas para obter o valor de crescimento. Apenas o grupo dentifrício apresentou redução nos níveis salivares de EGM, não sendo estatisticamente significativa pelo teste t de Student (alfa = 0,05).
Engineered Exosomes: A Promising Drug Delivery Strategy for Brain
Diseases
Authors: Jiang Yuan , Wang Fengbo , Wang Ke , Zhong Yongqiang , Wei Xiaofei , Wang Qiongfen , Zhang Hong
Published: September 2021

:

Exosomes are a heterogeneous group of nano-sized natural membrane vesicles
released from various cells and exist in body fluids. Different from the previous understanding
of the function of exosomes as “garbage bins”, exosomes act as carriers with
many kinds of bioactive molecules (e.g., proteins, lipids, and nucleic acids) to play an important
role in cell-cell communication. Growing evidence in recent years has suggested
that exosomes also play some roles in the pathogenesis, diagnosis, and treatment modalities
of some brain diseases, including ischemic stroke, Alzheimer's disease, Parkinson's
disease, multiple sclerosis, and brain cancers. Exosomes as therapeutic drug carriers for
brain drug delivery have received extensive attention as well as exosomes can overcome
the blood-brain barrier (BBB). However, the low targeting ability and size-dependent cellular
uptake of native exosomes could profoundly affect the delivery performance of exosomes.
Recent studies have indicated that engineered exosomes can increase the drug uptake
efficiency and the subsequent drug efficacy. In the present paper, we will briefly introduce
the engineering methods and applications of engineered exosomes in the treatment
of brain diseases, and then focus on discussing the advantages and challenges of exosome-
based drug delivery platforms to further enrich and boost the development of exosomes
as a promising drug delivery strategy for brain diseases.
Dual Targeting Strategies on Histone Deacetylase 6 (HDAC6) and Heat Shock Protein 90 (Hsp90)
Authors: Bonanni Davide , Citarella Andrea , Moi Davide , Pinzi Luca , Bergamini Elisa , Rastelli Giulio
Published: September 2021

:

The design of multi-target drugs acting simultaneously on multiple signaling pathways is a growing field in medicinal chemistry, especially for the treatment of complex diseases, such as cancer. Histone deacetylase 6 (HDAC6) is an established anticancer drug target involved in tumor cells transformation. Being an epigenetic enzyme at the interplay of many biological processes, HDAC6 has become an attractive target for polypharmacology studies aimed at improving the therapeutic efficacy of anticancer drugs. For example, the molecular chaperone Heat shock protein 90 (Hsp90) is a substrate of HDAC6 deacetylation, and several lines of evidence demonstrate that simultaneous inhibition of HDAC6 and Hsp90 promotes synergistic antitumor effects on different cancer cell lines, highlighting the potential benefits of developing a single molecule endowed with multi-target activity. This review will summarize the complex interplay between HDAC6 and Hsp90, providing also useful hints for multi-target drug design and discovery approaches in this field. To this end, crystallographic structures of HDAC6 and Hsp90 complexes will be extensively reviewed in light of discussing binding pockets features and pharmacophore requirements and providing useful guidelines for the design of dual inhibitors. The few examples of multi-target inhibitors obtained so far, mostly based on chimeric approaches, will be summarized and put into context. Finally, the main features of HDAC6 and Hsp90 inhibitors will be compared, and ligand- and structure-based strategies potentially useful for the development of small molecular weight dual inhibitors will be proposed and discussed.
Research Progress on the Natural Product Aloperine and Its Derivatives
Authors: Cheng Yu , Rauf Abdur , Pan Xiandao
Published: September 2021

In this review, an effort towards presenting an all-around account of the recent progress on
the natural product, aloperine, is made, and the antivirus structure-activity relationship of its derivatives
is also summarized comprehensively. In addition, the principal pharmacological effects and corresponding
molecular mechanisms of aloperine are discussed. Some new structural modifications of
aloperine are also given, which might provide brief guidance for further investigations on the natural
product aloperine.
Robust Discovery of Mild Cognitive Impairment Subtypes and Their Risk of Alzheimer's Disease Conversion Using Unsupervised Machine Learning and Gaussian Mixture Modeling
Authors: Nezhadmoghadam Fahimeh , Martinez-Torteya Antonio , Treviño Victor , Martínez Emmanuel , Santos Alejandro , Tamez-Peña Jose , Alzheimer’s Disease Neuroimaging Initiative
Published: September 2021

Background:

Alzheimer’s Disease (AD) is an irreversible, progressive brain disorder that
slowly destroys memory and thinking skills. The ability to correctly predict the diagnosis of Alzheimer’s
disease in its earliest stages can help physicians make more informed clinical decisions on
therapy plans.

Objective:

This study aimed to determine whether the unsupervised discovering of latent classes of
subjects with Mild Cognitive Impairment (MCI) may be useful in finding different prodromal AD
stages and/or subjects with a low MCI to AD conversion risk.

Methods:

Total 18 features relevant to the MCI to AD conversion process led to the identification of
681 subjects with early MCI. Subjects were divided into training (70%) and validation (30%) sets.
Subjects from the training set were analyzed using consensus clustering, and Gaussian Mixture Models
(GMM) were used to describe the latent classes. The discovered GMM predicted the latent class of the
validation set. Finally, descriptive statistics, rates of conversion, and Odds Ratios (OR) were computed
for each discovered class.

Results:

Through consensus clustering, we discovered three different clusters among MCI subjects.
The three clusters were associated with low-risk (OR = 0.12, 95%CI = 0.04 to 0.3|), medium-risk (OR
= 1.33, 95%CI = 0.75 to 2.37), and high-risk (OR = 3.02, 95%CI = 1.64 to 5.57) of converting from
MCI to AD, with the high-risk and low-risk groups highly contrasting. Hence, prodromal AD subjects
were present in only two clusters.

Conclusion:

We successfully discovered three different latent classes among MCI subjects with varied
risks of MCI-to-AD conversion through consensus clustering. Two of the discovered classes may represent
two different prodromal presentations of Alzheimer´s disease.
The Effect of Melissa officinalis on Premenstrual Syndrome and Primary
Dysmenorrhea in Women of Reproductive Age: A Systematic Review and
Meta-Analysis
Authors: Mirghafourvand Mojgan , Maghalian Mahsa , Ghassab-Abdollahi Nafiseh
Published: September 2021

Background:

Premenstrual syndrome (PMS) and dysmenorrhea are prevalent disabling
conditions and affecting the quality of life of women of reproductive age. Melissa officinalis exhibits
multiple pharmacological properties, including anti-inflammatory, antispasmodic, analgesic,
and antidepressant activities.

Objective:

The aim of this study was to systematically review the effect of Melissa officinalis on
PMS and primary dysmenorrhea.

Methods:

A systematic search in English (Embase ،PubMed, ProQuest, Scopus, Clininaltrial.gov,
Cochrane Library), and Persian (SID, Magiran, Iran Doc) databases to find articles was carried out
in May 2020. All types of clinical trials were included. Two authors independently selected the articles
and quality assessments and extracted the data. Standardized Mean Difference (SMD) was described
as a measure of effect size due to the application of multiple tools to measure the severity
of PMS. The quality of evidence was assessed using the GRADE approach.

Results:

A total of 978 articles were obtained from databases. Ultimately, 7 articles were included
in the study. Based on the results of these 7 studies, the consumption of Melissa officinalis
improved the symptoms of PMS and primary dysmenorrhea after treatment, as compared to the
control group. Also, from the meta-analysis results, the consumption of Melissa officinalis in the intervention
group as compared to the control group, significantly reduced the mean severity of PMS's
symptoms following treatment) SMD: -0.93; 95% CI: -.19 to -0.67; P=0. 88; I2=0%).

Conclusion:

Due to the limited number of articles included in the meta-analysis, conducting well-
designed clinical trials with large sample size to ascertain the effect of Melissa officinalis on PMS
and primary dysmenorrhea are recommended.
Choice of Restorative Materials for Direct Posterior Restorations among Undergraduate Saudi College Students
Authors: Iqbal Azhar , Khattak Osama , Fayyaz Alam , Issrani Rakhi , Alrasheed Osama Sulaiman , Almandel Mosleh Naeim , Alruwaili Abdullah Qanas
Published: September 2021

Background:

The most common restorative materials used in dentistry are amalgam and composite. Amalgam is a controversial material owing to its mercury toxicity. With recent advances in the properties of composite materials, there has been a shift towards its use.

Objectives:

The aim of this study was to understand the perceptions of undergraduate dental students in a northern Saudi Arabian dental school about the choice of restorative materials for restoring posterior teeth.

Methodology:

The study included undergraduate students studying in 4th and 5th year dental program in College of Dentistry, Jouf University. A four-item questionnaire with 18 close-ended questions was developed by the investigators, which were hand delivered to all the students. Data analysis is presented through tables and descriptive methods.

Results:

A total of 98 (out of 131) undergraduate students participated in this study. Overall, the students reported a significantly strong influence of the type of restorative materials in relation to the cavity size and margin of the restorations along with the esthetics factor(p<0.05). There was slight influence on the student’s choice because of the instructor's influence, whereas the students felt they were knowledgeable and had appropriate training to use either amalgam or composite. The study also found that patient’s preference had a strong influence on choosing composite material. The students were mostly not influenced while choosing the material as far as the safety of it was concerned. However, the patient’s influence was slight when it came to the choice of the material. A significant difference was noted among the students when it came to pregnancy-related safety concerns where the choice of material was not influenced by either amalgam or composite (p=.002).

Conclusion:

The undergraduate dental students at College of Dentistry, Jouf University are comfortable in using both amalgam and composite as a posterior restorative material. They are knowledgeable about both the materials and are adequately trained to use either one.
Initial Validation of a 33-Item Recovery-Stress Questionnaire for Italian Athletes
Authors: di Fronso Selenia , Robazza Claudio , Montesano Cristina , Bertollo Maurizio
Published: September 2021

Background:

The Recovery-Stress Questionnaire for Athletes (RESTQ-Sport-36) is a self-report measure intended to monitor the recovery-stress balance in athletes. A validated Italian version of this instrument was not available so far.

Objective:

The aim of this study was to provide an initial validation in Italian language of the RESTQ-Sport-36.

Methods:

A sample of Italian athletes (N = 339; women = 148; men = 191) from various sports completed the RESTQ-Sport-36 and the Italian Mood Scale (ITAMS). We examined the factorial validity and the internal consistency of the RESTQ-Sport-36 and its concurrent validity with the ITAMS.

Results:

A confirmatory factor analysis supported a 12-factor structure after the removal of 3 items. Reliability analysis showed a satisfactory internal consistency of the 33-item Recovery-Stress Questionnaire for Athletes (RESTQ-Sport-33). Pearson correlation coefficients revealed that the RESTQ-Sport-33 and ITAMS share some common variance but measure different constructs.

Conclusion:

Our results provided support to the factorial validity and reliability of the RESTQ-Sport-33. This instrument can be used to reliably monitor recovery-stress balance of Italian athletes throughout the season.
Working with Transgender Adolescents: Essential Guidelines and
Applications
Authors: Chou Kevin , Johnson Brandon
Published: September 2021

Background:

There has been a rise in the numbers of adolescents
identifying as transgender and seeking medical treatment for gender dysphoria.
While gender clinics are developing across the country, not all transgender
adolescents have access to these centers. There is, therefore, an increased need for
other clinicians to be aware of interventions and guidelines to help transgender
youth and their families.

Objective:

The aim of this article is to provide an overview of current literature and
guidelines for treating transgender adolescents with gender dysphoria.

Methods:

Using keywords “gender”, “gender dysphoria”, “transgender”, “trans*”,
“adolescent trans*”, the authors searched PubMed to gather current literature on treating
transgender adolescents. Additionally, sources from primary transgender resources online
were obtained, including current endocrine and psychological guidelines.

Results:

This article discusses important gender concepts that are relevant to treating
all transgender individuals. It describes models of engagement with transgender
adolescents seeking treatment, including assenting and consenting to medical
intervention. Finally, we discuss the assessment of transgender adolescents’ needs
and present an overview of the various guidelines outlining both non-medical and
medical interventions targeted to treat gender dysphoria in this population.

Conclusions:

Knowledge of treating adolescents with gender dysphoria is imperative
as gender dysphoria presents more commonly in practice. Multidisciplinary
collaboration is required to provide comprehensive treatment to this population.
Guidelines from professional organizations such as the World Professional
Association for Transgender Health and the Endocrine Society provide instructions
for clinical practice while the evidence base in this field continues to expand.
IDENTIFIKASI KETERKAITAN KOMUNIKASI DALAM KELUARGA DAN KEHARMONISAN KELUARGA PADA REMAJA SEKOLAH MENENGAH ATAS
Authors:   Department of Mental Health Nursing, School of Nursing, Faculty of Medicine, Universitas Brawijaya, Windarwati Heni Dwi , Hidayah Ridhoyanti , Nova Renny , Supriati Lilik , Ati Niken Asih Laras , Sulaksono Ari Dwi , Fitriyah Tsalatsatul , Kusumawati Mira Wahyu , Ilmy Erna Shofi Khaqul ,   Sekolah Tinggi Ilmu Kesehatan Bahrul Ulum, Jombang
Published: September 2021

Latar belakang: Keluarga merupakan bagian penting yang berperan dalam kesehatan remaja. Komunikasi dalam keluarga dan keharmonisan dalam keluarga berkaitan erat dengan perkembangan kesehatan mental remaja. Penelitian ini bertujuan untuk mengidentifikasi hubungan antara komunikasi dalam keluarga dengan keharmonisan dalam keluarga pada remaja sekolah menengah atas di Malang. Method: Penelitian ini merupakan penelitian kuantitatif dengan pendekatan crossectional. Populasi penelitian ini adalah remaja SMA yang bersekolah di MAN 2 Kota Malang, SMKN 11 Kota Malang dan Bululawang, Malang, Jawa Timur yang berusia 15 – 16 tahun. Teknik total sampling digunakan dalam pengambilan sampel penelitian dengan jumlah sampel 921 partisipan. Kuisioner self-reported komunikasi dalam keluarga dan keharmonisan dalam keluarga digunakan untuk mengidentifikasi kedua variable. Hasil: Hasil penelitian menunjukkan bahwa sebagian besar remaja memiliki komunikasi dalam keluarga yang adekuat (87,3%) dan memiliki keluarga yang harmonis (94.2%). Hasil analisis biavariat menunjukan bahwa tidak ada hubungan signifikan antara komunikasi dalam keluarga dengan keharmonisan keluarga dengan nilai p-value 0.246. Kesimpulan : komunikasi dalam keluarga tidak berhubungan signifikan dengan keharmonisan keluarga pada remaja. Penelitian ini memberikan tambahan literatur terkait hubungan antara komunikasi dan keharmonisan dalam keluarga serta dapat menjadi dasar dalam pemberian intervensi masalah kesehatan mental pada remaja.