bluuebunny/crossref_metadata_2025 huggingface dataset:
External Validity of the New York University Caregiver Intervention: Key Caregiver Outcomes Across Multiple Demonstration Projects
Authors: Fauth Elizabeth B. , Jackson Mark A. , Walberg Donna K. , Lee Nancy E. , Easom Leisa R. , Alston Gayle , Ramos Angel , Felten Kristen , LaRue Asenath , Mittelman Mary
Published: June 2017

Purpose of the Study: The Administration on Aging funded six New York University Caregiver Intervention (NYUCI) demonstration projects, a counseling/support intervention targeting dementia caregivers and families. Three sites (Georgia, Utah, Wisconsin) pooled data to inform external validity in nonresearch settings. This study (a) assesses collective changes over time, and (b) compares outcomes across sites on caregiver burden, depressive symptoms, satisfaction with social support, family conflict, and quality of life. Design and Methods: Data included baseline/preintervention ( N = 294) and follow-up visits (approximately 4, 8, 12 months). Results: Linear mixed models showed that social support satisfaction increased ( p < .05) and family conflict decreased ( p < .05; Cohen’s d = 0.49 and 0.35, respectively). Marginally significant findings emerged for quality of life increases ( p = .05) and burden decreases ( p < .10). Depressive symptoms remained stable. Slopes did not differ much by site. Implications: NYUCI demonstrated external validity in nonresearch settings across diverse caregiver samples.
Government Employees’ Organizational Citizenship Behavior Amid Organizational Resource Decline: Can They Work More With Less?
Authors: Shim Dong Chul , Park Hyun Hee , Jeong Seong Young
Published: June 2017

Based on the implication of the job demands–resources (JD-R) model, this study examined the associations between job demands (organizational resource declines and work overload) and resources (job-goal specificity, performance feedback, and work unit climate) with employees’ organizational citizenship behavior (OCB). Although statistically significant negative associations were found between financial and human resource decline and OCB, the associations were weak from a practical perspective. In line with the JD-R model, this study also found that job-goal specificity, performance feedback, and work supervisor support had positive associations with OCB. However, the effect of work overload was found to be marginalized, and the expected buffering role of job resources on the negative association of work overload with OCB was not confirmed in this study.
Factors Associated With Visual Impairment and Eye Care Utilization: The International Mobility in Aging Study
Authors: Balegamire Safari , Aubin Marie-Josée , Curcio Carmen-Lucia , Alvarado Beatriz , Guerra Ricardo O. , Ylli Alban , Deshpande Nandini , Zunzunegui Maria-Victoria
Published: June 2017

Objective:To examine factors associated with visual impairment (VI) and eye care in the International Mobility in Aging Study (IMIAS). Method: IMIAS data were analyzed ( N = 1,995 with ages 65-74). Outcomes were VI defined as presenting visual acuity worse than 6/18 in the better eye and eye care utilization assessed by annual visits to eye care professionals. The Hurt–Insult–Threaten–Scream (HITS) questionnaire requested information on domestic violence. Results: Among men, VI varied from 24% in Manizales (Colombia) to 0.5% in Kingston (Canada); among women, VI ranged from 20% in Manizales to 1% in Kingston; lifetime exposure to domestic violence was associated with VI (odds ratio [OR] = 1.87; 95% confidence interval [CI] = [1.17, 3.00]). Eye care utilization varied from 72% in Kingston’s men to 25% in Tirana’s men; it was associated with domestic violence (prevalence ratio [PR] = 1.3; 95% CI = [1.1, 1.6]). Discussion: VI is more frequent where eye care utilization is low. Domestic violence may be a risk factor for VI.
The ancient dispersal of millets in southern China: New archaeological evidence
Authors: Deng Zhenhua , Hung Hsiao-chun , Fan Xuechun , Huang Yunming , Lu Houyuan
Published: June 2017

This study presents the first direct evidence of millet cultivation in Neolithic southeast coastal China. Macroscopic plant remains and phytoliths, together with direct accelerator mass spectrometry (AMS) radiocarbon dates on crops, have shown that both foxtail millet and broomcorn millet were cultivated with rice in the Huangguashan and Pingfengshan sites in Fujian province around 4000–3500 cal. BP. Ratios of different parts of crop remains revealed that crop processing activities such as dehusking and sieving were conducted within the site and thus demonstrated the local production of these crops. The new data, especially the discovery of foxtail millet and broomcorn millet, have greatly changed the current knowledge about the ancient distribution of millet in South China and have now identified southeast China among the potential source-region of Neolithic crops transported overseas to Taiwan and Island Southeast Asia. This study further draws a potential dispersal route of Austronesian languages and people from southern China through Taiwan throughout Southeast Asia.
Mindful Place-Based Education: Mapping the Literature
Authors: Deringer S. Anthony
Published: June 2017

Place-based education and mindfulness are not new concepts, but the idea of combining the two bodies of work to explore what mindful place-based education might look like may provide a useful new perspective. The purpose of the literature review is to take place-based pedagogical methods and examine how mindfulness might influence the experience of educators engaged in place-based teaching. In this literature review, I examine the constructs of place-based education and sociocognitive mindfulness with special attention to literature that offers insight about possible overlap between the two constructs. I examine methodological choices and findings of foundational research describing both constructs. This literature review found that place-based education and mindfulness are closely linked, and that a mindful place-based pedagogy may help teachers and students experience place in a deeper way and think more critically about the societal norms and power structures that surround them. Outdoor educators should use mindful place-based education to help deepen student and teacher experiences of place with the intent of encouraging students to critically examine power structures and strive for deeper learning experiences.
iGlarLixi: A Fixed-Ratio Combination of Insulin Glargine 100 U/mL and Lixisenatide for the Treatment of Type 2 Diabetes
Authors: Goldman Jennifer , Trujillo Jennifer M.
Published: June 2017

Objective: To review the safety and efficacy of iGlarLixi, a titratable fixed-ratio combination of insulin glargine 100 U/mL (iGlar) and lixisenatide, a glucagon-like peptide-1 receptor agonist. Data Sources: A literature search of MEDLINE for all English-language primary articles through June 2016, using the terms LixiLan, iGlarLixi and insulin glargine and lixisenatide, and a search of abstracts presented at the 2016 Scientific Sessions of the American Diabetes Association were performed. Study Selection and Data Extraction: All studies assessing the efficacy and/or safety of iGlarLixi were evaluated. Data Synthesis: iGlarLixi has been approved in the United States for glycemic control in people with type 2 diabetes (T2D) inadequately controlled with basal insulin (<60 U/d) or lixisenatide. In clinical trials, iGlarLixi was associated with significantly greater reductions from baseline in glycated hemoglobin A1C (A1C) than iGlar or lixisenatide alone. Reductions in postprandial glucose were also greater with iGlarLixi than with iGlar or lixisenatide. iGlarLixi was weight neutral compared with the weight gain with iGlar and loss with lixisenatide alone, and there was no increase in hypoglycemia with iGlarLixi compared with iGlar despite the greater A1C reduction. Gastrointestinal events, frequently associated with lixisenatide, were less common with iGlarLixi. Potential drawbacks of iGlarLixi include reduced flexibility in dosing and the absence of long-term efficacy and safety data. Conclusions: iGlarLixi is a titratable fixed-ratio combination that shows improved efficacy and comparable or improved safety outcomes relative to its separate constituents, offering an alternative approach to intensification of therapy in T2D.
The Fragile Spell of Desire: A Functional Perspective on Changes in Sexual Desire Across Relationship Development
Authors: Birnbaum Gurit E.
Published: June 2017

The sexual behavioral system evolved to motivate reproductive acts by arousing sexual desire. Building on the idea that this system has also been “exploited” by evolutionary processes to promote enduring bonds between romantic partners, the present article introduces an integrative model that delineates the functional significance of sexual desire in relationship formation and maintenance. This model explains why individuals’ sexual reaction to their partner is context-dependent, clarifying how changes in the nature of interdependence over the course of relationships alter the ways in which specific predictors of sexual desire tend to promote (or inhibit) desire and thereby affect relationship depth and stability. The model postulates that although desire influences the development of attachment bonds, the contribution that it makes varies over the course of relationships. The model also provides new insight regarding fundamental but unresolved issues in human sexuality, such as the vulnerability of sexual desire and the desire-intimacy paradox.
Medical authority, managerial power and political will: A Bourdieusian analysis of antibiotics in the hospital
Authors: Kirby Emma , Broom Alex , Gibson Alexandra , Broom Jennifer , Yarwood Trent , Post Jeffrey
Published: June 2017

Antibiotic resistance poses a significant global threat, yet clinically inappropriate antibiotic use within hospitals continues despite the implementation of abatement strategies. Antibiotic use and the viability of existing antibiotic options now sit precariously at the nexus of political will, institutional governance and clinical priorities ‘at the bedside’. Yet no study has hitherto explored the perspectives of managers, instead of focusing on clinicians. In this article, drawing on qualitative interviews with hospital managers, we explore accounts of responding to antimicrobial resistance, managing antibiotic governance and negotiating clinical and managerial priorities. We argue that the managers’ accounts articulate the problematic nexus of measurement and accountability, the downflow effects of political will, and core tensions within the hospital between moral, managerial and medical authority. We apply Bourdieu’s theory of practice to argue that an understanding of the logics of practice within the ‘hospital management classes’ will be critical in efforts to protect antibiotics for future generations.
The role of sociocultural perspectives in eating disorder treatment: A study of health professionals
Authors: Holmes Su
Published: June 2017

Eating disorders are now often approached as biopsychosocial problems, because they are widely recognised as multifactorial in origin. However, it has been suggested that there is a substantial and unwarranted imbalance within this biopsychosocial framework, with the ‘social’ aspects of the equation relegated to secondary or facilitating factors within treatment contexts. Drawing on data from 12 qualitative interviews with health professionals in a UK region, this article examines the extent to which sociocultural perspectives on eating disorders are valued and explored in eating disorder treatment, with a particular focus on the relationship between eating disorders and gender. As girls/women are widely acknowledged to be disproportionately affected by eating problems, the article draws on feminist perspectives on eating disorders to explore whether the relationships between cultural constructions of femininity and experiences of body/eating distress are actively addressed within treatment. The study reveals high levels of inconsistency in this regard, as while some participants see such issues as central to treatment, others have ‘never really considered’ them before. In addition, the study examines the potential limitations of how such sociocultural issues are conceptualised and addressed, as well as why they might be marginalised in the current climate of evidence-based eating disorder treatment. The article then considers the implications of the findings for thinking about feminist perspectives on eating disorders – and the significance of gender in treatment – at the level of both research and practice.
Extended Periarterial Sympathectomy: Evaluation of Long-term Outcomes
Authors: Pace Collier S. , Merritt Wyndell H.
Published: June 2017

Background: Periarterial sympathectomy is a proposed surgical treatment for patients with refractory Raynaud syndrome; however, there is debate regarding the indications and extent of dissection. Due to the segmental arterial sympathetic innervation, we favor an extended sympathectomy in concert with vein graft reconstruction of occluded vessels when necessary. The purpose of this study is to examine outcomes of extended periarterial sympathectomy in our patients. Methods: A retrospective chart review was performed on 46 patients who underwent 58 periarterial sympathectomies (12 bilateral) since 1981. The data collected include demographics, comorbidities, previous therapy, operative details, and surgical outcomes. In addition, we contacted available patients for a phone survey. Results: Of 58 cases, 68.9% were female, 29.3% were current smokers, and 58.6% had known connective tissue disease. Thirty-three vein graft reconstructions were performed with a long-term patency of 77.4%. Sustained improvement of ischemic pain was reported in 94.8% of cases, and 78% of patients with ulcers completely healed. For the most symptomatic fingertip, mean Semmes-Weinstein monofilament measurements improved from 4.15 preoperatively to 3.29 postoperatively ( P ≤ .05). Mean follow-up was 3.97 years. Of 10 patients contacted by telephone, all reported a decrease in frequency and severity of Raynaud attacks, while 9 reported a long-term decrease in pain an average of 11.6 years after surgery. Conclusions: Extended periarterial sympathectomy is an effective and safe procedure for patients with refractory Raynaud syndrome. Our data demonstrate long-term improvement in ischemic pain and sensibility, along with a high rate of ulcer healing and patient satisfaction.
Appetite Regulation: Hormones, Peptides, and Neurotransmitters and Their Role in Obesity
Authors: Miller Gary D.
Published: June 2017

Understanding body weight regulation will aid in the development of new strategies to combat obesity. This review examines energy homeostasis and food intake behaviors, specifically with regards to hormones, peptides, and neurotransmitters in the periphery and central nervous system, and their potential role in obesity. Dysfunction in feeding signals by the brain is a factor in obesity. The hypothalamic (arcuate nucleus) and brainstem (nucleus tractus solitaris) areas integrate behavioral, endocrine, and autonomic responses via afferent and efferent pathways from and to the brainstem and peripheral organs. Neurons present in the arcuate nucleus express pro-opiomelanocortin, Neuropeptide Y, and Agouti Related Peptide, with the former involved in lowering food intake, and the latter two acutely increasing feeding behaviors. Action of peripheral hormones from the gut, pancreas, adipose, and liver are also involved in energy homeostasis. Vagal afferent neurons are also important in regulating energy homeostasis. Peripheral signals respond to the level of stored and currently available fuel. By studying their actions, new agents maybe developed that disable orexigenic responses and enhance anorexigenic signals. Although there are relatively few medications currently available for obesity treatment, a number of agents are in development that work through these pathways.
A web application for evaluating Phase I methods using a non-parametric optimal benchmark
Authors: Wages Nolan A , Varhegyi Nikole
Published: June 2017

Background/aims:

In evaluating the performance of Phase I dose-finding designs, simulation studies are typically conducted to assess how often a method correctly selects the true maximum tolerated dose under a set of assumed dose–toxicity curves. A necessary component of the evaluation process is to have some concept for how well a design can possibly perform. The notion of an upper bound on the accuracy of maximum tolerated dose selection is often omitted from the simulation study, and the aim of this work is to provide researchers with accessible software to quickly evaluate the operating characteristics of Phase I methods using a benchmark.

Methods:

The non-parametric optimal benchmark is a useful theoretical tool for simulations that can serve as an upper limit for the accuracy of maximum tolerated dose identification based on a binary toxicity endpoint. It offers researchers a sense of the plausibility of a Phase I method’s operating characteristics in simulation. We have developed an R shiny web application for simulating the benchmark.

Results:

The web application has the ability to quickly provide simulation results for the benchmark and requires no programming knowledge. The application is free to access and use on any device with an Internet browser.

Conclusion:

The application provides the percentage of correct selection of the maximum tolerated dose and an accuracy index, operating characteristics typically used in evaluating the accuracy of dose-finding designs. We hope this software will facilitate the use of the non-parametric optimal benchmark as an evaluation tool in dose-finding simulation.
A Quantitative Study of Empathy in Pakistani Medical Students: A Multicentered Approach
Authors: Tariq Nabia , Rasheed Tariq , Tavakol Mohsen
Published: June 2017

Objective:To examine the empathy level of undergraduate medical students in Pakistan. Three hypotheses are developed based on the literature review. (1) Female medical students have a higher level of empathy than do male students. (2) Empathy scores vary during the medical school years in Pakistani students. (3) Medical students interested in people-oriented specialties would score higher than the students interested in technology-oriented specialties. Methods: This is a quantitative inquiry approach using a cross-sectional design of 1453 students from 8 Pakistani medical schools, both private and state. The sample consists of 41.1% (n = 597) male students and 58.9% (n = 856) female students. Empirical data are collected using the Jefferson Scale of Physician Empathy (JSPE), a well-validated self-administered questionnaire. Results: The mean empathy score among students is 4.77 with a standard deviation of 0.72. The results show that there is no statistically significant association between the empathy scores and gender, t(1342.36) = −0.053, P = .95). There is a statistically significant difference between the empathy scores and the years of medical school, F(14, 1448) = 4.95, P = .01. Concerning the specialty interests, there is no statistically significant difference between the empathy score and specialty interests. Conclusion: The findings of this study showed that in Western countries, medical students performed better than Pakistani medical students on the empathy scale. This finding has important implications for Pakistani medical educators to improve the interpersonal skills of medical students in the context of patient care. Inconsistent with our expectations and experiences, our findings do not support that female medical students scored better than their male counterparts on the empathy scale. Because of the nature of a cross-sectional study, it is impossible to argue the decline of empathy during medical school training.
Power in International Business Communication and Linguistic Competence: Analyzing the Experiences of Nonnative Business People Who Use English as a Business Lingua Franca (BELF)
Authors: Takino Miyuki
Published: June 2017

This article demonstrates the complex nature of the relationship between linguistic competence and the level of disempowerment that individuals perceive in global business contexts where English is increasingly used as a lingua franca. Most of the existing literature assumes that lower linguistic competence causes disempowerment, and that this relationship is largely static for individuals. This study, in contrast, finds that the sense of disempowerment caused by linguistic competence is negotiable as power dynamics between individuals can also be influenced by other relationships that act as potential sources of power. As a result, even for those with lower linguistic proficiency, perceived disempowerment can be reduced if other power-yielding factors compensate. An analysis of the narratives of 34 Japanese businesses demonstrates that such factors include value-of-information, goal sharing, and economic relationships. This article concludes by presenting a theoretical contribution to the conceptualization of the power of linguistic competence and the implications for educators.
Alignment Accuracy and Cost-Savings Threshold of Patient-Specific Instrumentation In Total Ankle Replacements
Authors: Hamid Kamran , Matson Andrew , Nwachukwu Benedict , Scott Daniel , Mather Richard , DeOrio James
Published: June 2017

Category:

Ankle Arthritis

Introduction/Purpose:

Traditional intraoperative referencing for total ankle replacements (TAR) involves multiple steps and fluoroscopic guidance to determine mechanical alignment. Recent adoption of patient-specific instrumentation (PSI) allows for referencing to be determined preoperatively, resulting in less steps and potentially decreased operative time. We hypothesize that usage of PSI will result in decreased operating room time that offsets the additional cost of PSI as compared to standard referencing (SR). Additionally, we aim to demonstrate similar postoperative radiographic alignment between PSI and SR.

Methods:

Between 2014 and 2015, 87 patients undergoing TAR were enrolled in a prospectively collected TAR database. Patients were divided into cohorts based on PSI versus SR and operative times were reviewed. Radiographic alignment parameters were retrospectively measured at 6 weeks postoperatively. Time-driven activity-based costing (TDABC) was utilized to derive direct costs. Cost versus operative time-savings were examined via two-way sensitivity analysis to determine cost-saving thresholds for PSI applicable to a range of institution types. Cost-saving thresholds defined the price of PSI below which PSI is cost-saving.

Results:

A total of 35 PSI and 52 SR cases were evaluated with no significant differences identified in patient characteristics. Operative time from incision to completion of casting in cases without adjunct procedures was 127 minutes with PSI and 161 minutes with SR (p < 0.05). PSI demonstrated similar postoperative accuracy to SR in coronal tibial-plafond alignment (1.1° vs. 0.3° varus, p=0.06) and tibial component sagittal alignment (0.7° vs. 0.9° plantarflexion, p=0.14). TDABC methodology estimated a PSI cost-savings threshold range at our institution of $863 - $1,026 below which PSI pricing will provide net cost-savings. Two-way sensitivity analysis generated a globally applicable cost-savings threshold model based on institution-specific costs and surgeon-specific time-savings.

Conclusion:

This study demonstrates equivalent post-operative TAR alignment with PSI and SR referencing systems but with a significant decrease in operative time with PSI. Based on TDABC and associated sensitivity analysis, a cost-savings threshold of $863 - $1,026 is identified for PSI pricing at our institution below which PSI is less costly than SR. Similar internal cost accounting may benefit healthcare systems for identifying cost drivers and obtaining leverage during price negotiations.
Hindfoot Alignment of Adult Acquired Flatfoot Deformity
Authors: de Cesar Netto Cesar , Demehri Shadpour , Chinanuvathana Apisan , Mousavian Alireza , Tan Eric , O’Daly Andres , Aynardi Michael , Fonseca Lucas , Thawait Gaurav , Ficke James , Schon Lew
Published: June 2017

Category:

Hindfoot

Introduction/Purpose:

Assessment of hindfoot alignment in adult acquired flatfoot deformity (AAFD) can be challenging. Clinical judgment and radiograph studies while important may not represent the accurate valgus alignment of the affected patients. Weightbearing (WB) ConeBeam CT (CBCT) is an emerging imaging modality that may potentially better demonstrate the three-dimensional (3D) deformity, facilitating visualization of important soft-tissue and bony landmarks and helping in surgical planning. Based on the relative position of bone and soft-tissue axes, different measurements of hindfoot alignment can be obtained with CT images. Therefore, we compared clinical assessment of hindfoot valgus alignment in AAFD patients with different possible measurements performed on WB CBCT images.

Methods:

In this prospective, IRB-approved study, 20 patients (20 feet, 15 right and 5 left) with clinical diagnosis of flexible AAFD were included. There were 12 males and 8 females, with a mean age of 52.2 years (range, 20 – 88 years of age), and average BMI of 30.35 kg/m2 (range, 19.00 – 46.09 kg/m2). Patients underwent clinical assessment of hindfoot alignment as well as WB CBCT. Two independent and blinded foot and ankle board-certified surgeons performed different hindfoot alignment measurements on the WB CBCT images that included: 3D “clinical” alignment; Achilles tendon axis/calcaneal tuberosity angle; angles formed between the tibial axis and the calcaneal tuberosity, calcaneal axis and line connecting midpoint of subtalar joint and most inferior part of calcaneal tuberosity. Positive values were considered valgus alignment. Mean differences between the measurements modalities were compared by paired T-test. Intra- and Inter-observer reliability for the WB CBCT measurements were calculated using Pearson correlation.

Results:

The mean clinical hindfoot valgus measured was 15.15o (SD 7.7o). It was found to be significantly different from the mean values of all WB CBCT angles modalities: 3D “clinical” alignment (10.42o, p < 0.015); Achilles tendon/calcaneal tuberosity angle (2.96o, p < 0.0001); tibial axis/calcaneal tuberosity angle (5.42o, p < 0.0001); tibial axis/subtalar joint angle (7.52o, p < 0.0001) and tibial axis/calcaneal axis angle (20.39o, p < 0.017). We found an excellent intra-observer agreement for all WB CBCT 3D measurements (range, 0.8863 – 0.9713, p < 0.0001). There was also good to excellent inter-observer reliability, with the exception of the 3D “clinical” alignment (r=0.450, p < 0.04), that showed moderate correlation.

Conclusion:

The use of 3D WB CBCT imaging can help characterize the valgus hindfoot alignment in patients with adult acquired flatfoot deformity. We found the different CBCT measurements modalities to be reliable and repeatable, and to significantly differ from the clinical evaluation of hindfoot valgus alignment.
FAAM ADL Scores Correlate with PROMIS Physical Function, Pain Interference, and Depression Outcomes
Authors: Nixon Devon , McCormick Jeremy , Johnson Jeffrey , Klein Sandra
Published: June 2017

Category:

Midfoot/Forefoot

Introduction/Purpose:

Legacy patient-reported outcome instruments like the FAAM Activities of Daily Living (ADL) quantify patient disability but are often limited by responder burden and incomplete questionnaires. The Patient-Reported Outcome Measurement Information System (PROMIS) overcomes such obstacles through computer-adaptive technology to collect data on various health domains including Physical Function (PF), Pain Interference (PI), and Depression. Few reports, though, have examined PROMIS tools in lower extremity patients, and no study has examined PROMIS psychosocial outcomes like PI and Depression in foot and ankle conditions. We investigated the relationship between FAAM ADL and PROMIS measures, hypothesizing that FAAM ADL and PROMIS scores would correlate.

Methods:

All new patients with either a primary or secondary diagnosis of hallux valgus based on clinic billing codes from July, 2015 – February, 2016 were retrospectively identified. Patients with complete FAAM ADL paper-based surveys and electronic PROMIS questionnaires for PF, PI, and Depression were included. Spearman rho correlations were performed between FAAM ADL and PROMIS scores. Bivariate and multivariate analyses were then performed to identify differences in FAAM ADL and PROMIS PF measures based on select demographic variables (gender, comorbidities, marital status, employment status, prior foot and/or ankle surgery, and smoking status). Significant variables (P < 0.1) from bivariate and multivariate analyses were then entered into stepwise linear regressions to determine which variable(s) determined variance in FAAM ADL and PROMIS PF scores.

Results:

Eighty-five patients were identified (13 males, 72 females). FAAM scores significantly correlated with PROMIS PF (r = 0.70, P < 0.001), PI (r = 0.65, P < 0.001), and Depression (r = 0.35, P < 0.001) outcomes. Bivariate and multivariate analyses revealed significantly lower FAAM ADL scores in men (P = 0.02) and active smokers (P = 0.1). No significant group differences were detected for PROMIS PF scores (P > 0.1). Regression analyses demonstrated that PROMIS PI scores alone accounted for significant portions of the variance in FAAM ADL (R2 = 0.44, P < 0.001) and PROMIS PF (R2 = 0.57, P < 0.001) measures.

Conclusion:

PROMIS PF, PI, and Depression scores all correlated with FAAM ADL scores, highlighting the importance of understanding functional and psychosocial disability when assessing outcomes in lower extremity patients. Further, PROMIS PI results predicted significant portions of FAAM ADL and PROMIS PF scores, suggesting that function and pain are interrelated when measured by either traditional or modern outcomes instruments.
Headless Compression Screw Fixation of Jones Fractures
Authors: Ruta David , Ellis Robert , Grear Benjamin , Ishikawa Susan , Richardson David , Murphy Garnett
Published: June 2017

Category:

Sports

Introduction/Purpose:

There remains controversy over the ideal implant for intramedullary screw fixation of fifth metatarsal Jones fractures. Promising results have separately been reported for both indication-specific partially threaded screws and headless compression screws. The purpose of this study was to compare clinical and radiographic results between Jones fracture patients treated with indication-specific partially threaded screws to variable-pitched headless compression screws. We also evaluated the association of various patient and fracture characteristics with surgical failure.

Methods:

We performed a retrospective review and comparative analyses of all Jones fractures treated with primary intramedullary screw fixation by 4 foot and ankle fellowship-trained orthopaedic surgeons at a single institution from 1995 through 2015. Exclusion criteria included concomitant foot or ankle procedures and revision surgery. Charts were reviewed for patient and injury characteristics, implant, and postoperative course. Serial radiographs were examined for fracture classification (Torg and anatomic zone) and radiographic union. Primary endpoint was number of surgical failures, defined as delayed union, nonunion, or refracture. Secondary endpoints included time to each of radiographic union, weight bearing, and pain resolution. Data were analyzed using independent T test, one-way ANOVA, chi-square, and correlation analyses with significance defined as p < 0.05.

Results:

Fifty-nine feet were reviewed with mean age 30 years and follow-up 9.6 months. Forty-seven received a partially threaded screw (PT) and 12 feet a headless compression screw (HC). The PT group had more failures (10/47, 21.3% vs. 1/12, 8.3%; p=0.31) and more weeks to full weight (4.2 vs. 3.3, p=0.06), without significant differences in time to radiographic union or pain resolution. Most failures were delayed unions. Pooled union rate was 96.6%. Correlated with failure were age (r=0.469, p < 0.001), diabetes (r=0.390, p=0.002), and BMI (r=0.281, p=0.03), without significant correlation for tobacco, gender, or weight. Compared to Torg 1 and 2, Torg 3 fractures had greater time to pain resolution and radiographic union, age, weight, and BMI. No differences were found between zone II and III fractures.

Conclusion:

To our knowledge, this is the first reported clinical comparison between indication-specific partially threaded screws (PT) and headless compression screws (HC) for treating Jones fractures. This is also one of the largest clinical series on the subject. The two groups had similar clinical and radiographic results, both with high union rates. While most failures were delayed unions that ultimately healed, the 21% failure rate in the PT group is concerning and may warrant further investigation. Increasing patient age, diabetes, and BMI were associated with worse outcomes. These data support headless compression screw fixation as a viable treatment for Jones fractures.
Change is permanent: thoughts on the fading of cochineal-based watercolor pigments
Authors: Berrie Barbara H. , Strumfels Yoonjoo
Published: June 2017

Background

Color change in artworks has been commented on for centuries. Fading of watercolor pigments is a notable alteration. Pigments based on carminic acid are among those particularly prone to color loss, but the mechanism and factors are not well understood.

Results

We painted out three pigments prepared from the aqueous extract of carminic acid (CA) from Dactylopius coccus: the uncomplexed, and aluminium- and tin-complexed lakes. These were applied in a 2% gum Arabic solution to papers that were acidic, neutral or alkaline pH and exposed to accelerated light aging in a weatherometer. The comparative rate of fading was dependent on the complexation and on the pH of the substrate. On alkaline paper, the Al complex was least light stable, on neutral paper the three colorants responded similarly, and on acidic paper the tin complex was the least light stable. This is discussed in light of the published information on reactions and mechanism of color loss of CA.
Biological complications in implant-supported oral rehabilitation: as the pendulum swings back towards endodontics and tooth preservation
Authors: Nemcovsky Carlos E. , Rosen Eyal
Published: June 2017

The decision whether to retain a tooth by additional endodontic and restorative treatments or to extract it and replace it with an implant-supported restoration has been extensively debated, and the common approach to this clinical question has shifted back and forth many times. However, in recent years, it has become clear that implants are more prone to technical and biological complications, and require more postoperative treatments to maintain them than the natural dentition. A review of the currently available literature regarding the biological complications of implant-supported oral rehabilitation, and the ensuing effects on the clinical decision-making regarding the preservation of the teeth by endodontic treatments is presented.
Meis1 effects on motor phenotypes and the sensorimotor system in mice
Authors: Salminen Aaro V. , Garrett Lillian , Schormair Barbara , Rozman Jan , Giesert Florian , Niedermeier Kristina M. , Becker Lore , Rathkolb Birgit , Rácz Ildikó ,   German Mouse Clinic Consortium, Klingenspor Martin , Klopstock Thomas , Wolf Eckhard , Zimmer Andreas , Gailus-Durner Valérie , Torres Miguel , Fuchs Helmut , de Angelis Martin Hrabě , Wurst Wolfgang , Hölter Sabine M. , Winkelmann Juliane
Published: June 2017

MEIS1 is a developmental transcription factor linked to restless legs syndrome (RLS) in genome-wide association studies. RLS is a movement disorder leading to severe sleep reduction and with significant impact on the quality-of-life of patients. In genome-wide association studies, MEIS1 has consistently been the gene with the highest effect size and functional studies suggest a disease-relevant downregulation. Therefore, haploinsufficiency of Meis1 could be the most potential system for modeling RLS in animals. We used heterozygous Meis1 knock-out mice to study the effects of Meis1 haploinsufficiency on mouse behavioral and neurological phenotypes, and to relate the findings to human RLS. We exposed the Meis1-deficient mice to assays of motor, sensorimotor and cognitive ability and assessed the effect of a dopaminergic receptor 2/3 agonist commonly used in the treatment of RLS. The mutant mice showed a pattern of circadian hyperactivity, compatible with human RLS. Moreover, we discovered a replicable prepulse inhibition (PPI) deficit in the Meis1-deficient animals. In addition, these mice were hyposensitive to the PPI-reducing effect of the dopaminergic receptor agonist, highlighting a role of Meis1 in the dopaminergic system. Other reported phenotypes include enhanced social recognition at an older age that was not related to alterations in adult olfactory bulb neurogenesis previously shown to be implicated in this behavior. In conclusion, the Meis1-deficient mice fulfill some of the hallmarks of an RLS animal model, and revealed the role of Meis1 in sensorimotor gating and in the dopaminergic systems modulating it.
Deletion analysis of AGD1 reveals domains crucial for plasma membrane recruitment and function in root hair polarity
Authors: Yoo Cheol-Min , Naramoto Satoshi , Sparks J. Alan , Khan Bibi Rafeiza , Nakashima Jin , Fukuda Hiroo , Blancaflor Elison B.
Published: June 2017

AGD1, a plant ACAP-type ADP-ribosylation factor-GTPase activating protein (ARF-GAP), functions in specifying root hair polarity in Arabidopsis thaliana. To better understand how AGD1 modulates root hair growth, we generated full-length and domain-deleted AGD1-green fluorescent protein (GFP) constructs, and followed their localization during root hair development. AGD1-GFP localized to the cytoplasm and was recruited to specific regions of the root hair plasma membrane (PM). Distinct PM AGD1-GFP signal was first detected along the site of root hair bulge formation. The construct continued to mark the PM at the root hair apical dome, but only during periods of reduced growth. During rapid tip growth, AGD1-GFP labeled the PM of the lateral flanks and dissipated from the apical-most PM. Deletion analysis and a single domain GFP fusion revealed that the pleckstrin homology (PH) domain is the minimal unit required for recruitment of AGD1 to the PM. Our results indicate that differential recruitment of AGD1 to specific PM domains is an essential component of the membrane trafficking machinery that facilitates root hair developmental phase transitions and responses to changes in the root microenvironment.
Specialist palliative care nurses' management of the needs of patients with depression
Authors: Hayes Jessica Elizabeth , Hart Bethne , Phillips Jane
Published: June 2017

Background:

Depression is an important condition to consider if we are to optimise the care outcomes for patients with palliative care needs. Depression has a high incidence in palliative patients, with up to 15% diagnosed with major depression and 37% expressing some form of depressive symptoms ( O'Connor et al, 2010 ). The challenge is to ensure that palliative care patients with depression are identified in a timely manner and that their depression is effectively managed.

Aim:

To examine how Australian specialist inpatient palliative care nurses perceive, assess and respond to depression in a patient case study.

Method:

This descriptive pilot study is a replication of a United States study by Little et al (2005) , exploring contemporary Australian specialist palliative care nurses' screening, assessment and management of depression in people with a progressive life-limiting illness. A survey titled ‘Specialist palliative care nurses managing patients with complex care needs’ questioned the nursing assessment, knowledge and clinical care priorities related to a case vignette of a patient demonstrating signs of depression.

Results:

A total of 33 nurses completed this survey. Less than half (39.4%) of the participants identified depression as a major issue arising from the case vignette. Depression screening tools were not widely known. Functionality assessments measuring activities of daily living were the most recognised and widely used tools by participants.

Conclusion:

This small sample pilot study demonstrated that specialist palliative care nurses are still not confident in their screening and responding to a patient with depression. The available evidenced based depression screening tools were unfamiliar to these nurses and not widely used which can result in depression remaining undetected and undermanaged. The connections between physical health and mental health need stronger recognition and response within nursing care of palliative patients.
Research roundup
Authors: Costello John
Published: June 2017

Synopses of a selection of recently published research articles of relevance to palliative care.
Developing A Family-Size Biogas-Fueled Electricity Generating System
Authors: Haryanto Agus , Marotin Fadli , Triyono Sugeng , Hasanudin Udin
Published: June 2017

The purpose of this study is to develop a family-size biogas-fueled electricity generating system consisting of anaerobic digester, bio-filter scrubber, and power generating engine. Biogas was produced from a pilot scale wet anaerobic digester (5-m3 capacity). The biogas was filtered using bio-scrubber column filled with locally made compost to reduce hydrogen sulfide (H2S) content. Biogas composition was analysed using a gas chromatograph and its H2S level was measured using a H2S detector. A 750-W four stroke power generating engine was used with 100% biogas. Biogas consumed by the generator engine was measured at different load from 100 to 700 W (13.3 to 93.3% of the rated power). Three replications for each load experiment were taken. Results showed that the total biogas yield was 1.91 m3/day with methane content of 56.48% by volume. Bio-filter successfully reduced H2S content in the biogas by 98% (from 400 ppm to 9 ppm). Generator engine showed good performance during the test with average biogas consumption of 415.3 L/h. Specific biogas consumption decreased from 5.05 L/Wh to 1.15 L/Wh at loads of 100 W to 700 W, respectively. Thermal efficiency increased with loads from 6.4% at 100 W to 28.1 at 700 W. The highest thermal efficiency of 30% was achieved at a load of 600 W (80% of the rated power) with specific biogas consumption of 1.07 L/Wh.Article History: Received Janury 16th 2017; Received in revised form 2nd June 2017; Accepted 18th June 2017; Available onlineHow to Cite This Article: Haryanto, A., Marotin, F., Triyono, S., Hasanudin, U. (2017), Developing A Family-Size Biogas-Fueled Electricity Generating System. International Journal of Renewable Energy Development, 6(2), 111-118.https://doi.org/10.14710/ijred.6.2.111-118
Experiment and Simulation Effects of Cyclic Pitch Control on Performance of Horizontal Axis Wind Turbine
Authors: Sang Le Quang , Maeda Takao , Kamada Yasunari , Li Qing'an
Published: June 2017

Offshore wind is generally stronger and more consistent than wind on land. A large part of the offshore wind resource is however located in deep water, where floating wind turbines can harvest more energy. This paper describes a systematic experiment and a simulation analysis (FAST code) about the cyclic pitch control of blades. This work was performed to investigate performance fluctuation of a floating wind turbine utilizing cyclic pitch control. The experiment was carried out in an open wind tunnel with mainstream wind velocity of 10 m/s with the front inflow wind and the oblique inflow wind conditions. A model wind turbine is two-bladed downwind wind turbine with diameter of 1.6 m. Moment and force acts on the model wind turbine were measured by a six-component balance. Fluctuation of power coefficient and thrust coefficient was investigated in the cyclic pitch control. The model wind turbine and the experimental conditions were simulated by FAST code. The comparison of the experimental data and the simulation results of FAST code show that the power coefficient and thrust coefficient are in good agreement. Keywords: Floating Offshore Wind Turbine, Aerodynamic Forces, Cyclic Pitch Control, FAST Code, Wind Tunnel ExperimentArticle History: Received February 11st 2017; Received in revised form April 29th 2017; Accepted June 2nd 2017; Available onlineHow to Cite This Article: Sang, L.Q., Maeda, T., Kamada, Y. and Li, Q. (2017) Experiment and simulation effect of cyclic pitch control on performance of horizontal axis wind turbine to International Journal of Renewable Energy Development, 6(2), 119-125.https://doi.org/10.14710/ijred.6.2.119-125
Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation
Authors: Pünzeler Sebastian , Link Stephanie , Wagner Gabriele , Keilhauer Eva C , Kronbeck Nina , Spitzer Ramona MM , Leidescher Susanne , Markaki Yolanda , Mentele Edith , Regnard Catherine , Schneider Katrin , Takahashi Daisuke , Kusakabe Masayuki , Vardabasso Chiara , Zink Lisa M , Straub Tobias , Bernstein Emily , Harata Masahiko , Leonhardt Heinrich , Mann Matthias , Rupp Ralph AW , Hake Sandra B
Published: June 2017

Replacement of canonical histones with specialized histone variants promotes altering of chromatin structure and function. The essential histone variant H2A.Z affects various DNA‐based processes via poorly understood mechanisms. Here, we determine the comprehensive interactome of H2A.Z and identify PWWP2A as a novel H2A.Z‐nucleosome binder. PWWP2A is a functionally uncharacterized, vertebrate‐specific protein that binds very tightly to chromatin through a concerted multivalent binding mode. Two internal protein regions mediate H2A.Z‐specificity and nucleosome interaction, whereas the PWWP domain exhibits direct DNA binding. Genome‐wide mapping reveals that PWWP2A binds selectively to H2A.Z‐containing nucleosomes with strong preference for promoters of highly transcribed genes. In human cells, its depletion affects gene expression and impairs proliferation via a mitotic delay. While PWWP2A does not influence H2A.Z occupancy, the C‐terminal tail of H2A.Z is one important mediator to recruit PWWP2A to chromatin. Knockdown of PWWP2A in Xenopus results in severe cranial facial defects, arising from neural crest cell differentiation and migration problems. Thus, PWWP2A is a novel H2A.Z‐specific multivalent chromatin binder providing a surprising link between H2A.Z, chromosome segregation, and organ development.