Clinical Markers of the Heart and Blood Vessels Syntropic Lesions in Patients with Systemic Lupus Erythematosus, Their Diagnostic Value (Second Notice)
Authors: Kobak L. , Voloshyna O. , Khukhlina O. , Babinets L. , Chmyr N. , Guta S. , Ivanochko R. 
Published: November 2024

Introduction. Systemic lupus erythematosus (SLE) due to damage to numerous organs or systems still requires comprehensive study.
The aim of the study. To find out the clinical markers of the blood vessels syntropic lesions in patients with systemic lupus erythematosus, their diagnostic value.
Materials and methods. 118 patients with SLE with syntropic lesions of the circulatory system were examined (107 women (90.68 %) and 11 men (9.32 %) aged 18 to 74 years (average age 42.48 ±1.12 years)).
The study included the identification of clinical markers of blood vessels syntropic lesions, determination of the diagnostic value of individual clinical markers and their constellations in terms of sensitivity, specificity and accuracy in patients with SLE, and the identification of one of them with the most reliable diagnostic value.
Results. Clinical markers for detecting A. G. M. Raynaud’s syndrome in patients with SLE are morning stiffness, new rashes, paleness of the fingers and toes in the cold, chilliness of the extremities, memory problems, symptomatic hypertension - skin dryness, legs swelling, shortness of breath, palpitations, headache, increased blood pressure, displacement of the left border of the heart to the left, accent of the second tone on the aorta, livedo reticularis - skin dryness, chilliness of the extremities, shortness of breath,  retinal angiopathy - morning stiffness, paleness of the fingers and toes in the cold, legs swelling, shortness of breath, palpitations, headache, increased blood pressure, displacement of the left border of the heart to the left, accent of the second tone on the aorta, pulmonary hypertension - morning stiffness, legs swelling, shortness of breath, palpitations, memory problems, accent of the second tone on the pulmonary artery, atherosclerosis - muscle ache, shortness of breath, memory problems,  venous thrombosis - legs swelling, shortness of breath, palpitations, capillaritis - headache.
The optimal value for the diagnosis of A. G. M. Raynaud’s syndrome in patients with systemic lupus erythematosus is the constellation of clinical markers "joint pain + chilliness of the extremities", symptomatic hypertension - a separate clinical marker accent of the second tone on the aorta, livedo reticularis - "joint pain + new rash + shortness of breath", retinal angiopathy - "joint pain + increased blood pressure", pulmonary hypertension - a separate clinical marker accent of the second tone on the pulmonary artery or the constellation "joint pain + accent of the second tone on the pulmonary artery", atherosclerosis - a separate clinical marker shortness of breath or the constellation "joint pain + shortness of breath", venous thrombosis - "joint pain + photosensitivity + shortness of breath", capillaritis - "palpitations + headache + increased blood pressure".
Conclusions. In patients with systemic lupus erythematosus the optimal diagnostic value among clinical monomarkers and their constellations for the detecting of A. G. M. Raynaud’s syndrome have chilliness of the extremities, "joint pain + chilliness of the extremities" with an advantage in the constellation, symptomatic hypertension - accent of the second tone on the aorta, "joint pain + accent of the second tone on the aorta" with an advantage in the monomarker,  livedo reticularis - shortness of breath, "joint pain + new rash + shortness of breath" with an advantage in the constellation, retinal angiopathy - increased blood pressure, "joint pain + increased blood pressure" with an advantage in the constellation, pulmonary hypertension - accent of the second tone on the pulmonary artery or the constellation "joint pain + accent of the second tone on the pulmonary artery", atherosclerosis - shortness of breath or the constellation "joint pain + shortness of breath", venous thrombosis - legs swelling, "joint pain + photosensitivity + shortness of breath" with an advantage in the constellation, capillaritis - headache, "palpitations + headache + increased blood pressure" with an advantage in the constellation.