bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluating the Impact of Personalized Medicine on Cancer Treatment Outcomes
Authors: Muhammad Yaseen Ujjan  , Asia Noureen  , Dr Lubna Aftab  , Gilberto Mercado Mercado  , Marva Haroon  , Zeeshan Tahir
Published: January 2025

Background:
Personalized medicine has revolutionized cancer treatment by tailoring therapies to individual genetic and molecular profiles, enabling more targeted and effective interventions. Advances in genomic technologies, such as Next-Generation Sequencing (NGS), and biomarker analyses have allowed for precise identification of actionable mutations and personalized treatment strategies. However, understanding the clinical and economic implications of these approaches remains a priority to optimize their application in cancer care.
Objective:
This study aims to evaluate the clinical and economic impact of personalized medicine on cancer treatment outcomes, focusing on progression-free survival (PFS), overall survival (OS), quality of life, and cost-effectiveness. By comparing patients receiving personalized treatments with those undergoing standard care, the study seeks to assess the benefits and challenges associated with precision oncology.
Methods:
A retrospective cohort study was conducted at tertiary cancer centers, including patients diagnosed with breast, lung, and pancreatic cancer who underwent personalized medicine interventions. Genomic and molecular profiling was performed using NGS and biomarker analyses (e.g., PD-L1, EGFR, BRCA mutations). Outcomes such as PFS and OS were analyzed using Kaplan-Meier survival analysis and Cox proportional hazards models. Cost-effectiveness was evaluated through incremental cost-effectiveness ratio (ICER) calculations. Data sources included electronic health records (EHRs), cancer registries, and genomic databases such as The Cancer Genome Atlas (TCGA).
Results:
Patients receiving personalized medicine interventions demonstrated significantly improved PFS and OS compared to those on standard therapies (PFS: median 12.4 vs. 8.3 months; OS: median 24.6 vs. 18.7 months, p < 0.05). Biomarker-driven therapies exhibited the highest efficacy, particularly among patients with actionable mutations such as EGFR and BRCA. Cost-effectiveness analysis revealed that personalized medicine, while initially more expensive, resulted in better quality-adjusted life years (QALYs), making it economically viable in the long term.
Conclusion:
The findings underscore the transformative potential of personalized medicine in enhancing cancer treatment outcomes, with notable improvements in survival and quality of life. However, high costs and accessibility challenges must be addressed to ensure broader adoption. Future research should focus on scaling these interventions and exploring their utility across diverse populations and cancer types.
Polka Dots: A Timeless Design Element and Its Exploration with Sustainability
Authors:   Knitwear Design Department, NIFT Campus, Mithapur, Patna, Bihar, Jha Ranjeet Kumar , Chauhan Shweta ,   Knitwear Design Department, NIFT Campus Bhopal, MP., Nair Shalu V ,   Knitwear Design Department, NIFT Campus Dharamshala Kannur, Kerala.
Published: January 2025

This abstract presents an exploration of the evergreen glamour of polka dots as a design element and their potential role in advancing sustainability. It explores the synergy between the timeless charm of polka dots and the persistent need for sustainable design practices. The paper encompasses a comprehensive study of polka dots, including their various sizes and color combinations.

Furthermore, this research highlights how the enduring design element of polka dots can serve as a bridge between classic aesthetics and contemporary design trends. Data for this study has been collected from diverse sources, including surveys conducted among design enthusiasts including design students, faculties and fashion influencers. These surveys aim to uncover their perceptions and preferences regarding polka dots and other design elements that can seamlessly integrate with sustainable fibers and fashion.

The ultimate goal of this research is to provide valuable insights and guidance to fashion designers, retailers, and manufacturers interested in incorporating sustainability into their practices. By analyzing the data, the research has revealed that sustainable fabrics can harmonize effectively with polka dot patterns. This finding underscores the potential for polka dots to play a pivotal role in the sustainable fashion landscape, catering to both the traditional and contemporary tastes of consumers.
Nurturing Creativity in Indian Design Education: Insights and a Conceptual Mind Map
Authors:   National Institute of Fashion Technology, Hyderabad, Reddy G. Chiranjeevi
Published: January 2025

This study explores the perspectives of design educators in India on creativity as a critical skill in higher education, particularly in the context of the National Education Policy (NEP) 2020. Analyzing data from 131 educators who participated in a Faculty Development Program (FDP) focused on creativity, the research assessed the current state of creative exploration, interdisciplinary collaboration, and inclusivity in educational institutions. It identified significant gaps and proposed actionable strategies for improvement. A comprehensive mind map was also developed, integrating cognitive strategies, techniques, and traits to enhance creativity among educators and students. While 63% of educators regard creativity as essential, 30% believe their institutions lack sufficient creative thinking tools. While strong support exists for interdisciplinary collaboration (80.2%) and inclusivity (93.1%), 11% of educators report inadequate opportunities for creative exploration. The study emphasizes the need for enhanced training programs to improve educators’ proficiency with creative tools, the integration of design thinking and problem-solving methodologies into curricula, and the promotion of interdisciplinary projects to foster collaborative learning environments.
Reconceptualizing Vaastu Shastra Principles in Light of Modern Architectural Practices in India
Authors:   Amity School of Architecture and Planning Amity University Uttar Pradesh Lucknow Campus, Pande Rana Deepti , Siddiqui Samreen Siraj ,   Amity School of Architecture and Planning Amity University Uttar Pradesh Lucknow Campus, Tripathi Abhinav ,   Amity School of Architecture and Planning Amity University Uttar Pradesh Lucknow Campus, Narayan Nagendra ,   Lovely Professional University, Phagwara, Punjab, India
Published: January 2025

With an emphasis on the dynamic interaction between traditional knowledge and modern design, the study investigates how Vaastu Shastra is changing to satisfy the modern architectural landscape. The abstract seeks to illuminate the creative methods architects are using to balance traditional knowledge with the requirements of contemporary design in India’s architectural scene by looking at how these traditional concepts are being reinterpreted and integrated. This study examines how modern building approaches in India are blended with the ancient Hindu discipline of architectural design known as Vaastu Shastra. Vastu Shastra stresses designing areas to maximize natural light throughout the day, taking into account how the Sun moves in relation to the building. Though there are distinctions, there are also similarities and variations between Vastu Shastra principles and modern construction processes, despite the fact that modern buildings follow local building codes inspired by technology advancements. As a result, an effort has been made to incorporate traditional Vastu Shastra ideals into current house design approaches in order to improve both human well-being and environmental sustainability. This brief analysis identifies parallels and makes recommendations for implementing these concepts into social development programs.
Icon Design For Artifact Collection Classification At The Sri Baduga Museum, Bandung
Authors:   Univeritas Indraprasta, Jl. Nangka No. 58, Jakarta Selatan 12530, Indonesia, Tisna Ginanjar Putri Martha , Purnengsih Iis ,   Univeritas Indraprasta, Jl. Nangka No. 58, Jakarta Selatan 12530, Indonesia, Gunari Widya Wardani Winny ,   Univeritas Indraprasta, Jl. Nangka No. 58, Jakarta Selatan 12530, Indonesia, Vina Ayudyasari Nazwa ,   Univeritas Indraprasta, Jl. Nangka No. 58, Jakarta Selatan 12530, Indonesia, Raisya Hartono Andaru ,   Univeritas Indraprasta, Jl. Nangka No. 58, Jakarta Selatan 12530, Indonesia
Published: January 2025

The Sri Baduga Museum, established as the Technical Implementation Unit of the Tourism and Culture Office of West Java Province, was named in 1990 to honor Sri Baduga Maharaja, the Sunda King who ruled the Tatar Sunda region from 1482 to 1521. The Museum has ten classifications of historical artifacts from Sundanese, starting from prehistoric times to the colonial era. However, the classification has not had visual signs. This condition is a research gap for researchers to create iconic signs that visually convey ten collections of artifact museums. This study adopts quantitative and qualitative approaches. The collection of data is started by conducting a survey of young people to know their perspective of the museum’s collection. A visual communication approach was applied to develop iconic signs based on design elements: line, shape, space, colour, and texture. Icon design aims to represent the museum’s artifact classifications which consists of Geology, Numismatics, Biology, Philology, Ethnography, Ceramology, Archaeology, Fine Arts, History, and Technology. This research hopes that this icon design can contribute to Sri Baduga Museum according to the museum’s need. It is also hoped that this icon design can become a reference for other museums in developing information.
A Search for Sick Animals
Authors: Klee Trevor
Published: January 2025

A 2020 study suggests that monkeys can develop Parkinson’s, just like humans. Why haven't the findings been duplicated, and what will it take to find more “natural” animal models?
Impact of Relaxation Time from Improved Bloch NMR Fluid Flow Equation on NMR Signal of Blood Proton Spins using Laplace Transform Method
Authors: Rasheed Lateef A. , Timtere P. , Usman A. , Agada L. E.
Published: January 2025

Nuclear Magnetic Resonance (NMR) is a non-destructive spectroscopic technique in which the magnetization of a sample, such as human blood, changes by the application of both an external and radio frequency (RF) field to the sample. NMR is a non-invasive tool used in medicine and surgery for getting valuable information on blood flowing along the human blood vessels. In the existing work done on NMR signal, which is the transient state solution of the Bloch NMR fluid flow equation, it is noted that some NMR blood flow parameters, such as static magnetic field and Larmor precessional frequency of blood-spinning protons, are missing in the existing NMR signal equation. In order to solve this problem to generate accurate NMR signal results. This study developed a new NMR signal equation that contains the missing NMR parameter. Furthermore, the signal equation was used to investigate the effect of transverse relaxation times of arterial, venous, and capillary blood, respectively, on the NMR signal of blood proton spins. Laplace transform method was utilized to obtain the NMR signal, which is the closed-form solution of the improved Bloch NMR fluid flow time-dependent equation. MATLAB and Origin Pro software tools were utilized for the generation and simulation of data. Results of the simulation and analysis showed that for varied relaxation times of arterial, venous, and capillary blood, the NMR signal generated from the blood proton spins decreased with increasing time. This means that the blood proton spins gradually lose their alignment of magnetic moments, which is due to the interactions between neighboring blood proton spins. The results obtained from the simulations may be used as a means of validating the experimental results obtained from an NMR/Magnetic resonance imaging machine by providing a theoretical basis for comparison with the experimental data.
Design of High Performance Graphene Thin Films Perovskite Solar Cells by Numerical Modeling Based on Coupled Differential Equations
Authors: Ladan H. M. A. , Buba A. D. A. , Umar M. , Adamu A. S.
Published: January 2025

In this study, graphene a two dimensional nanomaterial was prepared by modified Hummer’s method and the optical properties were explored using UV-visible spectroscopy to determine absorption coefficients at different wavelengths based on Beer-Lambert’s law. Graphene based lead-free methyl ammonium germanium halide solar cell was designed in the second stage using graphene oxide (GO) as carrier absorbers and transporters. Numerical modelling of the device in solar capacitance stimulating (SCAPS 1D) program based on second order differential equation was done. A photovoltaic parameters of 0.6227 V, 38.58 mAcm-2, 83.07 %, 19.95 % were recorded as the open-circuit voltage, current density, fill factor and power conversion efficiency (PCE) for FTO/GO/Perovskite/Cu2O/Au. Using the same settings for the second design, the Au/spiro-ometad/FASnI3/TiO2/FTO, the current density increases sharply from 0.50 V and with valence and conduction band at -0.35 eV and 1.78 eV respectively. The light transmittance and heat distribution across the device determine by origin pro-version 9.8.0200 indicated uniform transmission and absorption. The study showed that the presence of graphene, improved the optical transparency and enhanced carrier generation and interaction between other layers which optimized the electrical conductivity and efficiency of the solar cells when compared to previous studies in the literature. The results emphasized a viable approach in the design of efficient and stable solar cells at a reduced cost and optical losses. If mass produced can be deployed commercially due to enhanced solar energy absorption potential ahead of the Si based PVCs.
La certificación y recertificación de especialistas en medicina familiar en Iberoamérica: Diagnóstico situacional 2024
Authors: Hernández Martínez Minerva Paulina , Fernández Ortega Miguel Ángel , Chávez Ciriaco Alejandra , Aguirre Vázquez Andrea Fernanda , López Lozano Miguel , Bernal Ocampo Dora Patricia
Published: January 2025

La certificación y recertificación de especialistas en medicina familiar generan confianza en que el médico cuenta con los conocimientos y habilidades necesarias para ejercer la especialidad, no obstante, en la mayor parte de los países de Iberoamérica no se efectúa. Los primeros esfuerzos para impulsar la recertificación en la región iberoamericana se efectuaron hace 21 años, en Isla Margarita, Venezuela (2003), durante la Mini-Cumbre de 2003. El objetivo de este informe fue identificar el estado actual de los procesos de certificación y recertificación de especialistas de medicina familiar en Iberoamérica. Se trata de un estudio transversal realizado por profesores e investigadores de la especialidad de Medicina Familiar en 19 países que conforman la WONCA-Iberoamericana-CIMF. Se recolectó la información con un cuestionario de 34 preguntas relacionadas con los procesos de certificación y recertificación de cada país. El cuestionario fue enviado por correo electrónico a cada uno de los investigadores participantes. Se advierte que nueve de los países estudiados tienen avances en materia de recertificación y seis de ellos, realizan procesos de evaluación tangibles, con procesos bien definidos y médicos certificados de manera voluntaria.
Socialmedicin för säkerhets skull 1954 - 2024
Authors: Jansson Bjarne
Published: January 2025

Presentationen beskriver utvecklingen från Berfenstams och Ehrenpries initiativ år 1954 om förebyggande av barnolycksfall och skadeforskningen i Lund via Skaraborgs hälsovårdsarbete till Karolinska Institutet och den internationella etableringen av säkra och trygga kommuner (Safe Communities). Verksamheten kännetecknas av ett arbete både på lokal, regional och nationell nivå. I fokus har varit en gränsöverskridande epidemiologisk och primärpreventiv samverkan mellan socialt arbete, socialmedicin och teknik.
Hälsovårdsenheten som förebild eller inspiration
Authors: Jansson Bjarne
Published: January 2025

Sjukvårdsdebatten i Skaraborg präglades under 1960-talet av en förskjutning mot en ökad satsning på primärvård och hälsovård. Det konstaterades att många sjukdomar och riskfaktorer bättre kunde påverkas i ett tidigare skede genom primärpreventiva metoder i lokalsamhället. En unik Hälsoplan både i tid och till innehåll beslutades av den politiska ledningen. Parallellt påbörjades en utbyggnad av primärvården där hälsovården skulle vara en integrerad del. Socialmedicin vid Lunds universitet hade bedrivit forskning inom området och engagerades i uppbyggnaden av en ny enhet – Hälsovårdsenheten. Syftet var utveckla epidemiologiska metoder och evidensbaserade förebyggande åtgärder till nytta för länets sjutton kommuner. En översikt av de politiska besluten och det förebyggande utvecklingsarbetet presenteras.
Research on the application of sports biomechanics in optimizing the effect of physical training
Authors: Gou Xiaofeng , Xiong Wei
Published: January 2025

This paper discusses the application of sports biomechanics in optimizing the effect of sports training, finds out the existing problems through quantitative evaluation of athletes’ technical movements, and puts forward improvement suggestions to maximize the training effect. In this study, 12 professional long jumpers were taken as the object, and advanced equipment such as high-speed photography, computer analysis and photoelectric timer were used to record the long jump movements of athletes in all directions, and the biomechanical parameters were analyzed. The results show that after four weeks of personalized training, the key performance indexes of athletes such as take-off speed, horizontal displacement, vertical jump height, landing technique and muscle strength have been significantly improved, and the average long jump performance has been significantly improved. Principal component analysis (PCA) reveals the key biomechanical factors that affect the performance of long jump, including take-off speed, horizontal displacement and vertical jump height. In addition, hierarchical cluster analysis helps to identify the technical characteristics and training needs of different athletes, which provides a basis for making personalized training plans. The results show that the application of sports biomechanics not only improves athletes’ performance, but also helps to reduce sports injuries and prolong sports life, and provides scientific training guidance for coaches. This study has important theoretical and practical value for promoting the development of sports science and improving the level of competitive sports.
L’utilità dell’agire urbanistico
Authors: Talia Michele
Published: January 2025

La riflessione sull'utilità del piano urbanistico è cruciale per valutare la capacità degli strumenti di pianificazione di soddisfare le aspettative delle comunità urbane. Spesso, l'agire urbanistico perde prestigio a causa della difficoltà di identificare obiettivi chiari e di prefigurare una cornice giuridica adeguata. La ricerca di una sintesi tra approcci cognitivi e normativi può migliorare il dibattito urbanistico. L'urbanistica deve evolversi come disciplina pratica, integrando innovazione e dibattito disciplinare. La proposta di riforma del governo del territorio mira a rendere la pianificazione più efficace e a rispondere alle sfide contemporanee come il cambiamento climatico e la transizione ecologica.
Biosfera
Authors: Ciccarese Lorenzo
Published: January 2025

La Terra ha circa 4,5 miliardi di anni. I fossili più antichi risalgono a 3,7 miliardi di anni, ma condizioni adatte alla vita esistevano già 600 milioni di anni prima. L'origine della vita è un mistero scientifico. La biosfera, la "zona della vita", si è sviluppata nel sottile strato esterno della geosfera, trasformando le condizioni ambientali. Le prime forme di vita, i procarioti, sopravvivevano senza ossigeno e alcuni svilupparono la fotosintesi, cambiando la composizione dell'atmosfera. L'attività umana ha alterato processi bio-geo-chimici, portando alla perdita dell'integrità della biosfera. Un rapporto IPBES rivela che circa 1 milione di specie sono a rischio di estinzione. Tuttavia, è possibile invertire il declino con azioni urgenti.
La rinuncia al futuro e qualche possibile rimedio
Authors: Talia Michele
Published: January 2025

Il futuro è percepito in modo diverso nel tempo, influenzando la capacità di immaginare scenari a lungo termine. La tendenza al "presentismo" limita la pianificazione e l'impegno collettivo. È necessario coltivare un'attitudine al futuro, coinvolgendo le comunità urbane. L'INU propone una legge per il governo del territorio che integra principi di sostenibilità, inclusività e rigenerazione urbana. La pianificazione deve combinare politiche a medio e lungo termine per affrontare sfide come il cambiamento climatico e la rigenerazione urbana. La pianificazione del territorio è essenziale per concepire e realizzare un futuro sostenibile.
Costa
Authors: D'Ascola Filippo
Published: January 2025

La costa italiana è un territorio dinamico che cambia continuamente. L'ISPRA mappa e monitora le coste, analizzando gli elementi naturali e antropici che influenzano la morfodinamica costiera. La gestione integrata delle zone costiere considera la fragilità degli ecosistemi e la diversità delle attività umane. La percezione della costa deve evolversi, riconoscendo la spiaggia come parte del fondale marino. La pianificazione e la progettazione lungo le coste richiedono un dettaglio analitico per supportare decisioni sostenibili.
The Affecting Mechanism of High School Students’ Family Cohesion on Positive Episodic Foresight in Jiangxi Province, China
Authors: Zhou Siya
Published: January 2025

Positive episodic foresight is the main factor influencing students’ future achievement. Therefore, how to effectively develop students’ psychological ability to experience future positive events in advance has become the focus, and cordial emotional relationships among family members are related to positive episodic foresight. Therefore, this study adopts ecological systems theory with a sample of 219 high school students from 3 schools in Jiangxi Province, China (validity rate 95.217%) to investigate the relationship between family cohesion and positive episodic foresight; the relationship between emphatic concern, water personality, and positive episodic foresight, as well as the facilitating role of emphatic concern and water personality. The results confirm that family cohesion is positively related to positive episodic foresight; emphatic concern and water personality are positively associated with positive episodic foresight; and emphatic concern and water personality have a facilitating effect among high school students in Jiangxi Province, China. This suggests that cordial emotional relationships among family members, concern for others, helpfulness, and the concept of natural humanity are determinants of enhancing the psychological ability of high school students in international classes in Jiangxi Province, China, to anticipate positive future events. In addition, high school students need cordial emotional relationships among family members, as well as caring and helpful behaviors towards others and the notion of natural humanity to adequately promote their psychological ability to pre-experience future positive events. Finally, the findings provide important insights for enhancing positive episodic foresight.
Quality Costing: A Key Tool for Enhancing Customer Satisfaction and Efficiency
Authors:   Government Bangur PG College, Arora Vineeta
Published: January 2025

Quality costing, also known as the Cost of Quality (COQ), is a strategic framework that helps organizations manage and improve the quality of their products and services while minimizing operational inefficiencies. In today's competitive business environment, ensuring high quality is not just an option but a necessity for organizations aiming to build customer loyalty and a strong market reputation. This paper delves into the critical components of quality costing, which include prevention costs, appraisal costs, internal failure costs, and external failure costs, each contributing to a comprehensive approach for managing quality-related expenses. Prevention costs are incurred to avoid defects before they occur, while appraisal costs focus on evaluating and inspecting products to ensure they meet quality standards. Internal failure costs arise from defects found before products reach customers, whereas external failure costs result from defects discovered after the product has been delivered to the customer, potentially damaging the organization’s reputation. Beyond its immediate financial benefits, quality costing facilitates informed decision-making by providing data that helps organizations assess quality risks and prioritize improvements. It plays a crucial role in reducing risks associated with product failures, thus enhancing competitive advantage in a highly dynamic market. Moreover, this paper explores various methods for measuring COQ, emphasizing that accurate measurement is key to realizing the full benefits of this tool. It also offers recommendations on how businesses can leverage quality costing to drive continuous improvement, foster innovation, and promote sustainability in their operations.
Assessing Computer-Assisted Education for Non-hospitalized Children with Learning Disabilities in Child Development Center, Hamad Medical Corporation (HMC)
Authors: Nursing Informatics Department  , Damian Rodson , Pedro Rocky V. San
Published: January 2025

Computer-assisted education technologies are commonly being used nowadays by Hamad Medical Corporation (HMC)'s pediatric multi-disciplinary rehabilitation team to promote learning and development of cognitive, sensory and motor skills for children with disabilities. Multi-disciplinary team services are delivered through individually tailored care plans aimed at developing each child's level of function and their quality of life. However, researches have shown that use of this advance technology comes with opportunities and challenges for both clinicians and patients, specifically non-hospitalized children with learning disabilities.  With the intent of maximizing positive outcomes of the devices and its applications used, the researchers would like to gain insight on the selection and use of computer-assisted education technologies for non-hospitalized children with learning disabilities in HMC. The study will utilize mixed method sequential explanatory design to depict of the current practice in the use of computer-assisted education technologies by health professionals in their management of non-hospitalized children with learning disabilities.  An adopted descriptive survey questionnaire tool and a qualitative phenomenological approach through individual interview will be conducted to gather data in this study. Responses will be analyzed using descriptive and inferential statistics to reveal what devices and applications are currently used in HMC for educating children with learning disabilities and what factors affect the use of computer-assisted education applications by these health professionals. Results of this study may serve as reference for health professionals, administrators and future researchers in developing strategies, frameworks and tools on technology selection and usage for their current services.
Climate Change - A Review of the Mass Balance of Biogenic and Fossil Carbon
Authors: Cobb Kirk T.
Published: January 2025

The purpose of this paper is to address, often, contradictory perspectives, regarding the growing concentration of carbon gases (primarily as CO2 and CH4) in Earth’s atmosphere, and the global warming that results. There are two primary sources of these gases: biogenic carbon sources, and fossil based carbon sources. Some will say that increased world (human) population, improved living standards, and the resulting expansion of modern agriculture, are all primary contributors to the rising carbon gases that are driving climate change. Others will suggest that the increased use of fossil fuels is the most significant generation of carbon gases and climate change. Could it be that both of these sources are contributing equally, or at least, significantly? To answer this dilemma, a “mass balance” study of these two, competing effects is offered in this paper. During this study, it was discovered that all the necessary data needed for this evaluation, can actually be found online, and all in the public domain. The core data include: 1) Current and historical atmospheric composition data, and total mass of Earth’s atmosphere (available from the NASA Earth-Fact-Sheet); 2) The “Keeling Curve”, which is now available from NOAA (United States - National Oceanic and Atmospheric Administration) which presents the rising concentration of CO2 in Earth’s atmosphere; 3) International fossil fuel emission data which are available from the Global Carbon Project and from the “Ourworldindata.org” website. After careful evaluation, the available data appear to show that the emissions from burning fossil fuels more than account for all of the rise of carbon dioxide in our atmosphere during the past 60 years. In comparison, the biogenic carbon cycle is a massive global phenomenon, which occurs year after years, having minimal impact on the rising atmospheric CO2 concentrations. What initially appears confusing, is that the annual biogenic data are huge in scale, compared to the much smaller, annual fossil emission data. An independent review of carbon isotopes (12C, 13C, 14C) used as trace elements, indicates a similar conclusion as this mass balance evaluation.
THEORETICAL FOUNDATIONS OF THE IMPLEMENTATION OF MODERN JAPANESE FOREIGN POLICY
Authors: Ashinova Zhanar
Published: January 2025

In the world, the main directions of each state's foreign policy develop depending on its historical position and national interests. The main goal of Japan's foreign policy is to ensure national security. The Blue Book of Japan, which clearly outlines the national strategy, introduces strategic concepts and recommendations annually. Accordingly, each Japanese Prime Minister necessarily presents his own view on foreign policy, his foreign policy concepts. The main purpose of the study is a comprehensive study of Japan's foreign policy in the 21st century when considering the proposed concepts and policies pursued by the Prime ministers of Japan. The scientific novelty of the research lies in the fact that the article analyzes the historical value and national structure of the main directions of the foreign policy of the Japanese state. The scientific significance of the research article analyzes Japan's task to overcome the contradictions between "soft power" and "hard power" based on post-war pacifism. The practical significance of the article lies in Japan's ability to quickly adapt to a changing world, review these changes and incorporate them into the National Strategy. Theoretical and empirical methods are used in this article. Because of these methods, a number of research approaches have been considered, such as analysis, synthesis, generalization, study of best practices, and observation. During the research, a large amount of literature related to the topic was used. Due to the coming to power of the Democratic Party system and the acceleration of the formation of a two-party system, the old methods of relations between the bureaucracy and politicians are in the process of significant restructuring. A number of specific characteristics of the foreign policy process in modern Japan can be identified.
FEATURES OF STRATEGIC PARTNERSHIP AND DIPLOMACY OF THE PEOPLE'S REPUBLIC OF CHINA IN CENTRAL ASIA
Authors: Birimkulova Gulnara , Tubysheva Aizat , Abzhapparova Bibikhadisha
Published: January 2025

Modern diplomacy of the People's Republic of China (PRC) is built of traditional and modern methods and mechanisms. Chinese diplomacy in Central Asia, aimed at creating sustainable economic, political and cultural ties, contributes not only to the development of the region, but also to the strategic interests of the PRC itself. The Central Asian region has rich energy resources and unique geopolitical conditions, and occupies an important place in the foreign policy strategy of the People's Republic of China. China's diplomacy in Central Asia is aimed at long-term strategic partnership, developing mutually beneficial relations and strengthening its influence in its key region. In the long term, China continues to strengthen such regional co-operation. The Chinese state's foreign policy strategies and diplomatic relations are constantly in the centre of attention and arouse great interest. The peculiarities of China's diplomacy and strategic partnership towards the CA countries require detailed study and scrutiny of the interaction between the countries. This article examines some aspects of China's diplomacy and strategic partnership towards the Central Asian region. China's strategic partnership with the Central Asian regions has evolved over the past decades, the current geopolitical situation and economic realities dictate new aspects of this co-operation, which still remain insufficiently studied. The novelty of the article lies in the fact that the study will highlight current trends in China's diplomatic initiatives and economic projects in the region. The authors examine the unique role of the One Belt, One Road initiative, which has transformed ties between China and Central Asian states, highlighting specific areas of influence - infrastructure projects, energy agreements and cultural exchange. The methodology of the article includes a systematic approach and empirical analysis. The aim of the article is to explore the main characteristics and strategic directions of China's diplomacy and economic co-operation with Central Asian states, as well as to identify the key factors that determine the nature of this interaction at the present stage. It is important to analyse how China is strengthening its position in the region through diplomatic, economic and cultural initiatives, as well as how its activities affect the overall balance of power and development of Central Asia. In the course of the research, the methods of event-analysis, comparative analysis, quantitative analysis, etc. were used. Statistical data on trade turnover, investment and other economic indicators were collected and analysed. This made it possible to assess China's economic influence on the countries of the region and identify key trends.
THE ROLE OF BIYS IN THE DIPLOMACY BETWEEN THE KAZAKH KHANATE AND EASTERN COUNTRIES
Authors: Tasilova Aigerim , Tasilova Naziya , Zhappassov Zharylkasyn
Published: January 2025

Kazakh public speaking has deep historical roots, originating from ancient times, when the word was the main means of transmitting knowledge and cultural values. The great biys and akyns, possessing the mastery of speech, played a key role in public life, resolving disputes, affirming moral norms and inspiring people to great deeds. The traditions of Kazakh oratory are still preserved, being an integral part of the national culture. The purpose of this scientific research is to identify the main directions and ideas in which Kazakh biy most effectively contributed to the development of the country through diplomatic activities. Also, it is necessary to identify their diplomatic relations with Eastern countries. The study will focus on analyzing their contributions to the political, social and cultural spheres, as well as identifying key factors and strategies used by biy to strengthen international relations and internal stability. The practical significance of this study lies in several key aspects. First, it will help to better understand the historical methods of diplomacy and their impact on modern diplomatic practices in Kazakhstan, which can contribute to improving the country's current foreign policy strategy. Secondly, the research can serve as a basis for the development of educational programs and educational materials aimed at studying the cultural and historical heritage of the Kazakh people. Finally, the results of the study can be used to strengthen national identity and unity, emphasizing the role of biy in the formation of Kazakh statehood and social values. The qualitative method was used in the research work. The works of biy-eloquent speakers from the XV century to the first half of the XIX century were analyzed, their work was diplomatically studied. The study found that biy played a significant role in conducting foreign policy in the diplomacy of the Kazakh Khanate from the XV to the first half of the XIX century.
化工工艺学双语课程教学思政元素的探索与融合
Authors: 徐丽  , 吴勇川  , 欧阳金波  , 张志宾  , 高志  , 吕鹏
Published: January 2025

化工工艺学作为化学工程与工艺专业的专业核心课程之一，上承专业基础理论课程，下接其他专业理论和实践课程。在课程教学中融入思政元素， 是夯实学生化工专业知识和培养学生家国情怀、工程伦理和职业素养的重要而有效的途径。本文根据化工工艺学对专业毕业要求支撑情况，梳理了本课程的“术”育和“道”育目标，从民族自豪感、社会责任感与使命感、辩证思维与科学创新、工程伦理与职业素养等方面对思政教育与课程教学的融入进行了探索；同时针对思政教学内容的教学设计、一个合理的、可衡量的“线上+线下”双通道过程性考核评价体系的构建进行了讨论，为化工工艺学课程教学改革提供了新思路。Chemical process engineering, as one of the core courses in the Chemical Engineering and Technology major, serves as a bridge between fundamental professional theoretical courses and other specialized theoretical and practical courses. Integrating ideological and political elements into course instruction is an important and effective method for students to strengthen their chemical engineering expertise and cultivate their sense of patriotism, engineering ethics, and professionalism. In this paper, the “technical” and “moral” teaching objectives were clarified based on the support provided by chemical process engineering for meeting the graduation requirements. The integration of ideological and political education into course teaching was explored from the perspectives of national pride, social responsibility and mission, dialectical thinking and scientific innovation, engineering ethics, and professionalism. Additionally, the teaching design for the ideological and political content, as well as the construction of a reasonable and measurable formative assessment system using both “online” and “offline” channels, was discussed. This approach provides a new perspective for the reform of chemical process engineering course teaching.
生成式人工智能（AIGC）教学科研培训教育部产学合作协同育人项目申报指南
Authors: 开来科技（深圳）有限公司
Published: January 2025

2025年，开来科技（深圳）有限公司拟支持生成式人工智能（AIGC）教学科研培训项目50项。通过系统化的师资培训、校企联合实践及AIGC（生成式人工智能）相关技术的深入应用，全面提升高校教师在人工智能领域的教学与科研能力，推动AIGC技术在教育教学中的深度融合。优化课程体系，构建基于AIGC的智能教学场景，增强课堂互动效果，推动个性化教学与教育教学模式的全面改革。通过引入ChatGPT、Claude及SakanaAI的AI Scientist等AIGC科研辅助工具，帮助教师和学生在科研工作中高效完成数据分析、模型构建与实验模拟，显著提升科研效率与创新能力。In 2025, Kailai Technology (Shenzhen) Co., Ltd. plans to support 50 projects focused on generative artificial intelligence (AIGC) teaching and research training. By implementing systematic faculty training, industry-university collaborative practices, and the in-depth application of AIGC technologies, the program aims to comprehensively enhance university educators’ teaching and research capabilities in the field of artificial intelligence. The initiative will promote the deep integration of AIGC technologies into educational practices, optimizing course structures and building intelligent teaching environments powered by AIGC. This approach seeks to improve classroom interactivity, foster personalized teaching, and drive a comprehensive reform of teaching and learning models. By leveraging AIGC research tools such as ChatGPT, Claude, and SakanaAI’s AI Scientist, the program will enable educators and students to efficiently perform data analysis, model development, and simulation experiments, significantly boosting research productivity and innovation capacity.
Diagnóstico da Depressão Pós-Parto: Desafios Clínicos e Caminhos para uma Identificação Precoce
Authors: Macedo Ryan Rafael Barros de , Sousa Thalita Duarte , Sutil Kamilly Vitória Fernandes , Campolina Gabriela Arbex , Fernandes Fernanda Pimenta , Vianna Laura Diniz Reis , Gomes Nelson Pinto , Guimarães Gustavo Henrique Ferreira , Massuda Aurélio Kazuo , Filho Almiro Sadao Massuda , Lourenço João Vitor de Paula , Previato Eduardo Pizaia , Silva Gustavo Francisco Santos da
Published: January 2025

A depressão pós-parto é uma condição prevalente e preocupante, representando um significativo problema de saúde pública global. Apesar de diretrizes claras estabelecidas por organizações como o Colégio Americano de Obstetrícia e Ginecologia (ACOG) e a United States Preventive Services Task Force (USPSTF), a triagem universal permanece subutilizada, com taxas de implementação inferiores a 40%. Entre os principais obstáculos estão a falta de tempo, treinamento inadequado e sistemas de triagem ineficazes. Ferramentas como a Escala de Depressão Pós-parto de Edimburgo (EPDS) e o PHQ-9 têm demonstrado eficácia na identificação da condição, especialmente quando associadas a acompanhamento contínuo e intervenções terapêuticas adequadas. Este estudo, baseado em uma revisão sistemática da literatura, destaca as desigualdades no acesso ao diagnóstico e tratamento, particularmente entre mulheres de grupos vulneráveis. Programas como os implementados na Polônia, que capacitam profissionais de saúde não especializados para diagnosticar e tratar a depressão pós-parto, emergem como modelos promissores. A discussão reforça a necessidade de políticas públicas que incentivem a capacitação de profissionais e a integração de cuidados colaborativos para abordar as barreiras existentes. Uma abordagem multidisciplinar, aliada à implementação de estratégias de triagem eficazes, é essencial para melhorar os desfechos clínicos, reduzir o subdiagnóstico e minimizar os impactos sociais e econômicos da depressão pós-parto.
EVALUASI PELAKSANAAN PROGRAM DESA LAYAK ANAK DI DESA MELINGGIH KELOD, KECAMATAN PAYANGAN, KABUPATEN GIANYAR
Authors: Ratna Dewi Ni Wayan Kembar , Suryawan Dewa Ketut , Mirta I Wayan
Published: January 2025

Anak merupakan aset bangsa yang berharga karena memiliki potensi kekayaan dan kesejahteraan bangsa pada masa mendatang. Dalam rangka memenuhi hak-hak anak maka pemerintah membuat suatu program kebijakan tentang upaya Pengembangan Kota Layak Anak (KLA) sebagaimana yang dijelaskan dalam Peraturan Menteri Negara Pemberdayaan Perempuan dan Perlindungan Anak Nomor 11 tahun 2011 tentang Kebijakan Pengembangan Kabupaten/Kota Layak Anak. Di Gianyar di Desa Melinggih Kelod, kecamatan payangan kabupaten Gianyar merupakan Desa yang pertama mendeklarasikan diri sebagai Desa Ramah Anak di Kabupaten Gianyar. Peneliti melakukan penelitian di Desa Melinggih Klod dengan tujuan mengkaji lebih dalam terkait program Desa Layak Anak. Peneliti bermaksud mengevaluasi program Desa Layak Anak yang sudah berjalan dari tahun 2015 di Desa Melinggih Klod. Berdasarkan tujuan penelitian tersebut, maka metode yang digunakan dalam penelitian ini adalah teknik analisis data kualitatif dengan tujuan untuk memperoleh data dan mengumpulkan informasi yang lengkap untuk mendeskripsikan terkait evaluasi program Desa Layak Anak di Desa Melinggih, Kecmatan Payangan, Kabupaten Gianyar. Hasil penelitian menunjukan program desa layak anak di desa melinggih kelod dalam proses program desa layak anak sudah berjalan baik saat ini tapi masih ada kendala di proses kegiatannya masih belum bisa berjalan maksimal karena masih kurangnya fasilitas jadi untuk kegiatannya belum bisa berjalan lancar jadi kegiatannya belum berjalan maksimal.
The Effect of Financing Behaviours on Firm Value with moderating Role of Earning Management in Non-Financial Sector
Authors: Farah Arzu  , Faisal Iqbal  , Muhammad Haseeb  , Muhammad Abubakar Ali Syed  , Shagufta Shaheen  , Muhammad Faizan Afridi
Published: January 2025

The study investigates the relationship between financing behavior, earnings management, and firm value, focusing on a sample of non-financial firms over the period 2014-2023. A sample of stratified sampling techniques, 202 firms were selected from the population. In the fixed-effects model, the study explores the impact of debt usage (leverage) on firm value, considering earnings management as a moderating variable. The findings reveal a positive and significant relationship between financing behavior and firm value, which is consistent with the Trade-Off Theory, Modigliani & Miller Theorem, Pecking Order Theory, and Agency Theory. These theories suggest that strategically using debt can enhance firm value by exploiting tax shields, improving managerial discipline, and aligning shareholder-manager interests. However, the study also finds that the moderating effect of earnings management leads to a sign reversal in the relationship between financing behavior and firm value. This relationship shows a substitution effect. This result is explained through Agency Theory, Signaling Theory, Trade-Off Theory, and Pecking Order Theory, which highlight that earnings management can either amplify or distort the true impact of financing behavior on firm value. Earnings management, when used to signal financial stability or manage financial distress, can alter investors' perceptions and affect the financial health of firms. The analysis indicates that while earnings management can be beneficial in certain contexts, excessive manipulation may undermine the positive effects of debt on firm value. The study contributes to the literature by providing empirical evidence on how financing behavior, moderated by earnings management, affects firm value, with implications for corporate financial strategies and policy-making.
Clinical Research and Mechanism Exploration of Moxibustion in Promoting Children's Growth and Development
Authors: Sun Xize , Sun Ximan
Published: January 2025

To evaluate the effect of moxibustion on children's growth and development and explore its underlying mechanisms. A total of 60 children with growth and development retardation were randomly divided into a moxibustion treatment group and a control group. The treatment group received moxi-bustion at specific acupoints, while the control group received no interven-tion. The height, weight, and bone age of the children were measured be-fore and after treatment, and relevant hormones and growth factors were detected. After treatment, the height, weight, and bone age of the children in the moxibustion treatment group were significantly improved compared with those in the control group. The levels of growth hormones and insulin-like growth factor-1 in the treatment group were also significantly increased. Moxibustion can effectively promote children's growth and development, and its mechanism may be related to the regulation of growth hormones and growth factors.
Prevalence and Impact of Hypomania Among Night-Shift Healthcare Professionals
Authors: Adnan Wajih Akhtar  , Ahad Kareem Khan  , Muhammad Kashif Azeem  , Ali Shahbaz  , Maira Khalil  , Asima Munawar
Published: January 2025

Objective: This study aimed to investigate the prevalence and impact of hypomanic symptoms among healthcare professionals (HCPs) working night shifts, focusing on behavioral, mental, and physical health outcomes, as well as stimulant use and attitudes toward night shifts. Methods: A cross-sectional study was conducted among HCPs from Shaikh Zayed Hospital, Lahore, using the validated Hypomania Checklist (HCL-32). The survey included questions on demographic and occupational factors, stimulant consumption, and hypomanic symptoms, rated on a five-point Likert scale. Data were analyzed using SPSS version 25 for descriptive and inferential statistics, with p < 0.05 considered significant. Ethical approval was obtained, and participant confidentiality was ensured. Results: Among 200 respondents, 22.5% consumed coffee, 10.5% smoked, and 7.5% used drugs, while alcohol use was low (2%). Positive impacts of night shifts included increased energy (71.5%), confidence (77.5%), and optimism (59.5%). Negative outcomes were significant, with 53.5% reporting exhaustion, 48% irritability, and 49.5% distractibility. Behavioral changes included greater sociability (58%) and a playful personality (70.5%). Conclusion: The findings emphasize the need for structured mental health support and policy interventions to enhance the well-being of HCPs while maintaining high standards of patient care.