bluuebunny/crossref_metadata_2025 huggingface dataset:
Struggling with distinction: How and why people switch between cultural hierarchy and equality
Authors: van den Haak Marcel , Wilterdink Nico
Published: July 2019

In research on cultural taste and distinction, inconsistent and ambivalent attitudes towards hierarchy versus equality have largely been ignored. This study shows, by means of in-depth interviews with 90 Dutch people on their own and others’ cultural tastes, that both a hierarchical and an egalitarian repertoire appear in people’s narratives, and that these repertoires are often used simultaneously. People still distinguish culturally from others, but not consistently and often reluctantly, as they morally object to high–low distinctions based on aesthetic evaluations at the same time. This article analyses both repertoires and explores when and how tensions between the two come forward. We interpret these tensions on the micro level of self-presentation and habitus, and on the macro level of changing structures of inequality and meritocratic ideas.
Expectations for cross-ethnic inclusion by Asian American children and adolescents
Authors: Hitti Aline , Elenbaas Laura , Noh Jee Young , Rizzo Michael T. , Cooley Shelby , Killen Melanie
Published: July 2019

Asian American youth’s inclusion decisions were investigated in cross-ethnic peer contexts (Asian and non-Asian). Ten-, 13-, and 16-year-old participants ( N = 134), enrolled in U.S. schools, decided whether to include a same-ethnic peer with different interests or a different-ethnic peer with similar interests. Findings showed that with age, participants more frequently included a peer who shared interests even when this peer was not of the same ethnicity. Participants expected their peer groups to be equally inclusive of others of both ethnic backgrounds, and expected that in-group parents would be less inclusive of cross-ethnic peers. In addition, adolescents expected parents to have prejudicial attitudes about ethnic out-group members. Views about peer group and in-group parents’ inclusivity diverged from adolescents’ own inclusivity. These findings point to areas for intervention regarding the promotion of cross-group friendships and the reduction of prejudice.
A model-driven approach to automate data visualization in big data analytics
Authors: Golfarelli Matteo , Rizzi Stefano
Published: July 2019

In big data analytics, advanced analytic techniques operate on big datasets aimed at complementing the role of traditional OLAP for decision making. To enable companies to take benefit of these techniques despite the lack of in-house technical skills, the H2020 TOREADOR Project adopts a model-driven architecture for streamlining analysis processes, from data preparation to their visualization. In this article, we propose a new approach named SkyViz focused on the visualization area, in particular on (1) how to specify the user’s objectives and describe the dataset to be visualized, (2) how to translate this specification into a platform-independent visualization type, and (3) how to concretely implement this visualization type on the target execution platform. To support step (1), we define a visualization context based on seven prioritizable coordinates for assessing the user’s objectives and conceptually describing the data to be visualized. To automate step (2), we propose a skyline-based technique that translates a visualization context into a set of most suitable visualization types. Finally, to automate step (3), we propose a skyline-based technique that, with reference to a specific platform, finds the best bindings between the columns of the dataset and the graphical coordinates used by the visualization type chosen by the user. SkyViz can be transparently extended to include more visualization types on one hand, more visualization coordinates on the other. The article is completed by an evaluation of SkyViz based on a case study excerpted from the pilot applications of the TOREADOR Project.
A Darling® of the beauty trade: race, care, and the imperial debris of synthetic hair
Authors: Faria Caroline V , Jones Hilary
Published: July 2019

This article pushes for a postcolonial geography of care, through hair. Working with the ‘imperial debris’ of care as a disciplinary racial logic, we show how it is renewed, remade, and resisted in the present through the travels, narratives, and practices of the African synthetic hair trade. Here we interrogate Lebanese business expansion, entrepreneurialism, manufacture, and styling, tracing in each case how contemporary narratives of care mirror, entrench, and rework colonial ideals and subjectivities of Whiteness. Disrupting these logics, we close by attending to the influences of Ugandan stylists and consumers who draw on Caribbean, US-American, and other diasporic circuits of Blackness, along with locally rooted innovations. Our work demonstrates how racial power travels through time and across space, asserting the important and sustained insights of a postcolonial geography of care.
Demystifying AI: What Digital Transformation Leaders Can Teach You about Realistic Artificial Intelligence
Authors: Brock Jürgen Kai-Uwe , von Wangenheim Florian
Published: July 2019

Recent years have seen a reemergence of interest in artificial intelligence (AI) among both managers and academics. Driven by technological advances and public interest, AI is considered by some as an unprecedented revolutionary technology with the potential to transform humanity. But, at this stage, managers are left with little empirical advice on how to prepare and use AI in their firm’s operations. Based on case studies and the results of two global surveys among senior managers across industries, this article shows that AI is typically implemented and used with other advanced digital technologies in firms’ digital transformation projects. The digital transformation projects in which AI is deployed are mostly in support of firms’ existing businesses, thereby demystifying some of the transformative claims made about AI. This article then presents a framework for successfully implementing AI in the context of digital transformation, offering specific guidance in the areas of data, intelligence, being grounded, integrated, teaming, agility, and leadership.
Medium-Term Effects of a Train Derailment on the Physical and Psychological Health of Men
Authors: Maltais Danielle , Lavoie-Trudeau Étienne , Labra Oscar , Généreux Mélissa , Roy Mathieu , Lansard Anne-Lise , Fortin Geneviève
Published: July 2019

In July 2013, the derailment of a train caused the death of 47 people and the destruction of Lac-Mégantic’s downtown area (Canada). Three years after this event, a population survey was conducted among a representative sample of 800 adults, including 282 men. Several significant differences were observed among respondents of a survey based on their level of exposure to this tragedy, including their physical (changes in physical health) and psychological health (post-traumatic stress disorder, mood and anxiety disorders, psychological distress, signs of depression, consultation of social workers and psychologists) as well as their use of prescribed (anxiolytics and antidepressants) and nonprescribed drugs. Such results can be explained by the nature, magnitude, and cause of the event.
Influence of 3-Hydroxyflavone on Colloidal Stability and Internationalization of Ag Nanomaterials Into THP-1 Macrophages
Authors: Liang Yongqi , Xie Min , Li Juan , Liu Liangliang , Cao Yi
Published: July 2019

Polyphenols as typical food components can influence the colloidal properties and internalization of nanomaterials (NMs) into mammalian cells. Recently, we found that 3-hydroxyflavone (H3) promoted intracellular Zn ions in ZnO nanoparticle (NP) exposed Caco-2 and HepG2 cells. However, it is unclear if H3 could affect the internalization of metal-based NMs with different morphologies. This study investigated the influence of H3 on colloidal aspects of Ag NPs and Ag nanoflakes (NFs) as well as the internalization of Ag NMs into THP-1 macrophages. 3-Hydroxyflavone at 50 μM promoted the solubility and altered hydrodynamic size, polydispersity index, and ζ potential of Ag NPs and Ag NFs, which indicated that H3 could affect the colloidal stability of Ag NMs. Only H3 but not Ag NMs significantly decreased mitochondrial activities of THP-1 macrophages. The internalization of Ag NMs was markedly increased due to the presence of H3. 3-Hydroxyflavone also exhibited antioxidative properties as it reduced intracellular reactive oxygen species and promoted the activities of ABC transporters as it reduced retention of Calcein in Ag NM-exposed THP-1 macrophages. We concluded that H3 promoted the internalization of Ag NMs into macrophages probably by altering the colloidal stability of Ag NMs and consequently NM-macrophage interactions.
Barriers to and Facilitators of Implementing DEPENAS Biopsychosocial Intervention in Primary Care: A Study Protocol
Authors: Sarriugarte Jose María Aiarzaguena , Cifuentes Maite Espinosa , Inda Idoia Gaminde , Baranda Leticia Isla , PedreroJocano Juan Eduardo , Varona Enrique de la peña , Garicano Juan Ignacio del Pozo , Lavado Javier González , Vallejo Susana Martinez
Published: July 2019

Background:

Our team has developed a biopsychosocial intervention called DEPENAS that has shown to be effective in primary health care in improving health and quality of life of patients with medically unexplained symptoms. We also found that general practitioners participating in the clinical trial do not use the intervention systematically because of barriers related to psychological determinants among professionals themselves. Based on the Theoretical Domains Framework (TDF) of Susan Michie, our study aims (1) to identify psychological determinants among professionals who are perceived to be facilitators of or barriers to the systematic and generalized use of the intervention in the consultation room and (2) to design an implementation strategy that considers these determinants and helps us to address them with a series of predesigned and validated techniques.

Method:

A qualitative exploratory study has been designed based on semistructured individual interviews conducted following a script based on the 14 TDF domains and analyzed in a deductive way. Participants will be doctors and nurses previously trained in the intervention that was put into practice under real-world conditions, from different health centers. Results of the analysis of the interviews will be used as the basis for designing the implementation strategy.

Discussion:

The implementation of the DEPENAS intervention in primary care to achieve its sustained and widespread use among primary care professionals involves changes in the model of patient care and the model of the health system, toward models that are more in tune with the needs of modern society. Investigating psychological determinants in professionals and addressing them with validated techniques, as part of the strategy for implementing a given intervention, is a novel approach that has the potential to help change the way in which we tackle change in healthcare organizations.
Clinicopathological significance and prognostic implication of programmed death-1 ligand 2 expression in colorectal cancer
Authors: Pyo Jung-Soo , Son Byoung Kwan , Chung Kwang Hyun , Oh Il Hwan
Published: July 2019

Purpose:

The aim of this study was to evaluate the clinicopathological significance and prognostic role of programmed death-1 ligand 2 (PD-L2) expression in colorectal cancer according to intratumoral components.

Methods:

We used immunohistochemical analysis to investigate the impact of PD-L2 expression on clinicopathological characteristics and survival in 264 human colorectal cancer tissues. We also evaluated the correlation between PD-L2 expression and PD-L1 expression.

Results:

PD-L2 was expressed in 17.4% of the tumors (T-PD-L2) and in 19.3% of the immune cells (I-PD-L2) of the 264 CRC tissues. I-PD-L2 expression was significantly correlated with favorable tumor behaviors, including lower pathologic tumor stage, less lymph node metastasis, less distant metastasis, and lower pathologic tumor node metastasis stage. There was no significant correlation between I-PD-L2 expression and T-PD-L2 expression ( P = 0.091). However, I-PD-L2 expression was correlated with PD-L1 expression in the immune cells ( P < 0.001). There was also a significant correlation between high Immunoscore and I-PD-L2, but not T-PD-L2 ( P < 0.001 and P = 0.190, respectively). The prognosis was better for patients who expressed I-PD-L2 than for patients who did not. In patients who expressed I-PD-L2, there was a significant difference in the survival rate between subgroups according to the presence or absence of T-PD-L2 expression.

Conclusions:

Our results suggest that I-PD-L2 expression is significantly correlated with favorable tumor behaviors and better survival rates. There is also a significant correlation between PD-L2 expression and PD-L1 expression in immune cells.
Dynamic reliability evaluation of vehicle–track coupled systems considering the randomness of suspension and wheel–rail parameters
Authors: Zhang Yahui , Wang Wei , Ouyang Huajiang
Published: July 2019

The ride quality and running safety of high-speed trains are directly influenced by uncertainties of some key parameters, such as the damping and stiffness coefficients of suspension systems, wheel–rail coefficient of friction and wheel–rail profiles. Dynamic reliability problems of vehicle–track coupled systems under the influence of the above random parameters are studied in this article. An efficient numerical method is presented by combining a prediction-based iterative solution technique with subset simulation method. The solution efficiency of deterministic responses is improved by means of efficient prediction of wheel–rail forces, and the number of deterministic solutions required is reduced by expressing a small failure probability as a product of large conditional probabilities. The accuracy and the efficiency of the present method are verified by comparing with the direct Monte Carlo simulation. The failure probability distribution curves of the lateral ride index on straight track and the derailment coefficient during curve negotiation are obtained and the reliability sensitivity analyses are also carried out. The main conclusions are given as follows: the reliability of the system is higher when the randomness of the parameters with greater sensitivity is not considered; the increase of the damping of anti-yaw damper or the wheel–rail coefficient of friction will improve the ride quality on straight track, but will lower the running safety when negotiating a curved track.
Co-authoring desistance narratives: Analysing interactions in groupwork for addressing sexual offending
Authors: Mullins Eve , Kirkwood Steve
Published: July 2019

Research and theory suggest that desistance narratives and pro-social identities are key to the process of desistance from crime. However, little research has examined how desistance narratives and related identities are produced in contexts other than research interviews or how core correctional skills intersect with the development of these narratives or identities. This study applies discourse analysis and conversation analysis to transcripts of 12 video-recordings of groupwork sessions for addressing sexual offending, examining how desistance narratives and identities are produced, and how practitioner skills and conversational styles intersect with their production. The analysis illustrates how criminal justice practitioners help to co-author desistance narratives through subtle and explicit aspects of interaction, although certain orientations to risk may limit this potential.
Endoscopy in inflammatory bowel disease: from guidelines to real life
Authors: Negreanu Lucian , Voiosu Theodor , State Monica , Voiosu Andrei , Bengus Andreea , Mateescu Bogdan Radu
Published: July 2019

Endoscopy has a central role in the management of inflammatory bowel disease (IBD), providing crucial data for diagnostic and therapeutic decisions, treating disease-related complications, and assisting in the early detection of dysplasia and prevention of colorectal cancer in the setting of IBD. Treatment targets have significantly shifted in IBD, focusing on achieving mucosal healing, a more meaningful endpoint than clinical remission. With the emergence of novel therapies, we aim to alter the course of the disease and prevent irreversible damage to the bowel. To that end, obtaining reliable and reproducible assessments of endoscopic disease activity has become an issue of great importance. Although several guidelines include recommendations regarding endoscopic surveillance in patients with long-standing IBD, there is an open debate regarding the best examination method and the appropriate follow-up intervals. Another important issue is whether surveillance guidelines are actually implemented in real-life practice and what is the preferred surveillance method among endoscopists. Significant changes have occurred in the endoscopic world with the development of new diagnostic and therapeutic modalities and their incorporation in everyday practice. We aimed to assess the real-life application of guideline recommendations regarding endoscopy in IBD patients and to review newly emerged data which might impact these recommendations in the near future.
Magnetic resonance imaging findings in a patient with cryopyrin-associated periodic syndrome: A rare hereditary multi-system inflammatory disorder
Authors: Behringer Jessica , Ryan Maura , Miller Michael , Jaju Alok
Published: July 2019

Cryopyrin-associated periodic syndrome is a hereditary inflammatory disorder encompassing a wide spectrum of clinical phenotypes. This disorder has been associated with mutation of the NLRP3 gene coding for cryopyrin, which leads to overproduction of interleukin-1. The condition causes relapsing bouts of inflammation involving multiple organ systems, including the central nervous system, and, if untreated, can lead to long-term debilitating effects. A literature review revealed only a few brief descriptions of magnetic resonance imaging findings in cryopyrin-associated periodic syndrome patients. We describe serial magnetic resonance imaging findings in an 11-year-old female with clinically diagnosed cryopyrin-associated periodic syndrome who presented with intermittent headaches, progressive sensorineural hearing loss, fevers, and abdominal pain. The magnetic resonance imaging showed progressively worsening low T2 signal in the cochlea, cochlear enhancement, and leptomeningeal enhancement. We also describe some previously unreported findings in this syndrome, including cranial nerve and cauda equina enhancement.
Effect of NaOH treatment on mechanical strength of banana/epoxy laminates
Authors: Khan Mujahid , Rahamathbaba Sayyadh , Mateen MA , Ravi Shankar DV , Manzoor Hussain M
Published: July 2019

The present study is focused on studying the effect of alkali treatment on the mechanical properties of banana fiber-reinforced epoxy composites. Four batches of samples were prepared with respect to the percentage of sodium hydroxide (NaOH) in the treatment solution (0%, 2.5%, 4.5%, and 6.5%). Later mechanical tests such as tensile, compressive, and interlaminar shear tests were conducted on the prepared composite specimens to determine the influence of alkali treatment on the mechanical characteristics. The test results indicate an overall improvement in all the mechanical properties due to the fiber treatment. Moreover, the samples made from the fiber treated with 4.5% of NaOH solution indicated the highest tensile strength and compressive strength, with an overall increment of 24.2% and 34.8% in tensile and compressive strengths, respectively, when compared with the untreated sample. A linear increment in interlaminar strength is observed with a maximum value of 25.4 N/mm2 for the sample made from the fiber treated with 6.5% of NaOH solution. This increase is due to the fiber flattening process which increases the bonding surface at the interface.
Berberine reduces neuroglia activation and inflammation in streptozotocin-induced diabetic mice
Authors: Liu Mei , Gao Linlin , Zhang Na
Published: July 2019

We aimed to analyze the action of berberine on the neuropathic pain and neuroglia activation in experimental diabetes mellitus (DM) model. Diabetes in mice was induced by intraperitoneal injection of streptozotocin (STZ) followed by the administration of berberine. Mechanical allodynia and thermal hyperalgesia and activations of microglia and astrocytes were evaluated. The levels of pro-inflammatory cytokines and protein expressions of inflammatory proteins were assessed by enzyme-linked immunosorbent assay (ELISA) and western blot, respectively. Our results revealed the anti-nociceptive effects of berberine in DM mice, supported by the improved mechanical threshold and thermal latency. In addition, berberine suppressed the activations of microglia and astrocytes in the spinal cords of diabetic mice. Berberine inhibited the expression of pro-inflammatory cytokines including tumor necrosis factor (TNF)-α, interleukin-6 (IL-6), and interleukin-1β (IL-1β), along with inflammatory proteins including iNOS and COX-2. Berberine suppressed neuropathic pain in STZ-induced diabetic mice, and this effect is related to the reduction on the neuroglia activation and inflammation associated with DM.
Why Are Women Penalized in Product Markets?
Authors: Kricheli-Katz Tamar , Regev Tali , Correll Shelley
Published: July 2019

Previous research using data from eBay found that women receive lower prices than men when selling the exact same products. The current project explores why this gender gap obtains and why some products have larger gender price gaps than others. To answer these questions, we exploit the variation in the gender price gap across products found in the earlier eBay data together with new survey data on the perceptions people have about seemingly male-typed and female-typed products and about people’s uncertainty about the prices of products. We show that women are penalized more for selling products that are perceived to be typically owned by men compared to products that are perceived to be typically owned by women. We further demonstrate that the effects of gender stereotypes are greater when buyers’ uncertainty increases: when buyers are uncertain about their willingness to pay for a product or about its market price, women sellers are penalized more.
Deep learning-based strategies for the detection and tracking of drones using several cameras
Authors: Unlu Eren , Zenou Emmanuel , Riviere Nicolas , Dupouy Paul-Edouard
Published: July 2019

Commercial Unmanned aerial vehicle (UAV) industry, which is publicly known as drone, has seen a tremendous increase in last few years, making these devices highly accessible to public. This phenomenon has immediately raised security concerns due to fact that these devices can intentionally or unintentionally cause serious hazards. In order to protect critical locations, the academia and industry have proposed several solutions in recent years. Computer vision is extensively used to detect drones autonomously compared to other proposed solutions such as RADAR, acoustics and RF signal analysis thanks to its robustness. Among these computer vision-based approaches, we see the preference of deep learning algorithms thanks to their effectiveness. In this paper, we are presenting an autonomous drone detection and tracking system which uses a static wide-angle camera and a lower-angle camera mounted on a rotating turret. In order to use memory and time efficiently, we propose a combined multi-frame deep learning detection technique, where the frame coming from the zoomed camera on the turret is overlaid on the wide-angle static camera’s frame. With this approach, we are able to build an efficient pipeline where the initial detection of small sized aerial intruders on the main image plane and their detection on the zoomed image plane is performed simultaneously, minimizing the cost of resource exhaustive detection algorithm. In addition to this, we present the integral system including tracking algorithms, deep learning classification architectures and the protocols.
Early intervention in psychosis: health economic evaluation using the net benefit approach in a real-world setting
Authors: Behan Caragh , Kennelly Brendan , Roche Eric , Renwick Laoise , Masterson Sarah , Lyne John , O'Donoghue Brian , Waddington John , McDonough Catherine , McCrone Paul , Clarke Mary
Published: July 2019

Background

Early intervention in psychosis is a complex intervention, usually delivered in a specialist stand-alone setting, which aims to improve outcomes for people with psychosis. Previous studies have been criticised because the control used did not accurately reflect actual practice.

Aims

To evaluate the cost-effectiveness of early intervention by estimating the incremental net benefit (INB) of an early-intervention programme, delivered in a real-world setting. INB measures the difference in monetary terms between alternative interventions.

Method

Two contemporaneous incidence-based cohorts presenting with first-episode psychosis, aged 18–65 years, were compared. Costs and outcomes were measured over 1 year. The main outcome was avoidance of a relapse that required admission to hospital or home-based treatment.

Results

From the health sector perspective, the probability that early intervention was cost-effective was 0.77. The INB was €2465 per person (95% CI − €4418 to €9347) when society placed a value of €6000, the cost of an in-patient relapse, on preventing a relapse requiring admission or home care. Following adjustment, the probability that early intervention was cost-effective was 1, and the INB to the health sector was €3105 per person (95% CI −€8453 to €14 663). From a societal perspective, the adjusted probability that early intervention was cost-effective was 1, and the INB was €19 928 per person (95% CI − €2075 to €41 931).

Conclusions

Early intervention has a modest INB from the health sector perspective and a large INB from the societal perspective. The perspective chosen is critical when presenting results of an economic evaluation of a complex intervention.
“Ganz Unmusikalisch”: Freud’s Seconda Prattica
Authors: Reitman Nimrod
Published: July 2019

The article reads Sigmund Freud and Claudio Monteverdi’s understanding of musicality, its affinity with rhetoric, and the way this relation informs their individual oeuvres. Both Monteverdi and Freud, each in his own way, were condemned to live with an aversion to musicality that strengthened their hermeneutics of psychic and discursive disturbance. Through the specific rhetorical figure of the musical lament found in psychoanalytical discourse, the article demonstrates the way dissonances implicate opera, the madrigal, and the talking-cure, making aporetic claims, especially in the face of Freud’s self-attestation—his resolute conviction that he was “ganz unmusikalisch”—which astonishingly matches Monteverdi’s own resistance to music.
“Good to Think With”: The Work of Objects in Three Novels of Modern Jewish Life
Authors: Mann Barbara E.
Published: July 2019

This essay analyzes the depiction of “things” in three modernist novels: Dovid Bergelson’s The End of Everything (Yiddish, 1913), a tale of ennui set in a provincial town outside Kiev, where faded fabrics and cherished ornaments in drawing rooms emblematize the end of an era; Henry Roth’s Call It Sleep (1934), where the detritus of a Lower East Side childhood become symbolic totems of a violent coming-of-age; and S. Y. Agnon’s Just Yesterday (Hebrew, 1946), an epic novel of immigration, cultural renaissance, and insanity set in Jaffa and Jerusalem, wherein taxidermy and olive-wood craft figure as metonymic symbols of a new national self. My comparative reading of these novels highlights a complementary set of conditions—objects in books, and the book as object. I argue that the genre’s engagement with things, and its emergence as a thing, suggests how writing both fears and revels in its own commodification and immersion in the economic sphere. These novels exemplify how modern, transnational Jewish literature was reconceived as material culture.
Heartsick: The Language of French Disgust
Authors: Freed-Thall Hannah
Published: July 2019

The rhetoric of revulsion has shaped French cultural modernity. This essay examines salient forms of nineteenth- and twentieth-century French literary disgust, then turns to écœurement (heartsickness) as a contemporary case study. Écœurement is key to the work of the philosopher Jean-Luc Nancy and the novelist and playwright Marie NDiaye. These thinkers embrace heartsickness as a state of exposure that unsettles discourses of philosophical mastery and practices of social refinement. The essay thus shows that the language of disgust is not necessarily reactionary and nostalgic—as has often been argued—but can enable new forms of collective resistance and attachment.
MOZ directs the distal-less homeobox gene expression program during craniofacial development
Authors: Vanyai Hannah K. , Garnham Alexandra , May Rose E. , McRae Helen M. , Collin Caitlin , Wilcox Stephen , Smyth Gordon K. , Thomas Tim , Voss Anne K.
Published: July 2019

Oral clefts are common birth defects. Individuals with oral clefts who have identical genetic mutations regularly present with variable penetrance and severity. Epigenetic or chromatin-mediated mechanisms are commonly invoked to explain variable penetrance. However, specific examples of these are rare. Two functional copies of the MOZ (KAT6A, MYST3) gene, encoding a MYST family lysine acetyltransferase chromatin regulator, are essential for human craniofacial development, but the molecular role of MOZ in this context is unclear. Using genetic interaction and genomic studies, we have investigated the effects of loss of MOZ on the gene expression program during mouse development. Among the more than 500 genes differentially expressed after loss of MOZ, 19 genes had previously been associated with cleft palates. These included four distal-less homeobox (DLX) transcription factor-encoding genes, Dlx1, Dlx2, Dlx3 and Dlx5 and DLX target genes (including Barx1, Gbx2, Osr2 and Sim2). MOZ occupied the Dlx5 locus and was required for normal levels of histone H3 lysine 9 acetylation. MOZ affected Dlx gene expression cell-autonomously within neural crest cells. Our study identifies a specific program by which the chromatin modifier MOZ regulates craniofacial development.
Further Studies on Ni/Zr-mediated One-pot Ketone Synthesis: Use of a Mixture of NiI- and NiII-catalysts Greatly Improves the Molar Ratio of Coupling Partners
Authors: Umehara Atsushi , Kishi Yoshito
Published: July 2019

A new Ni/Zr-mediated one-pot ketone synthesis is developed, with use of a mixture of (Me)3tpy·NiII- and py-(Me)imid·NiIICl2-catalysts. The NiI-catalyst selectively activates iodides, whereas the NiII-catalyst activates thio-pyridine esters. An adjustment of a relative loading of the two catalysts allows to tune the relative rate of the two activations and trap a short-lived radical intermediate(s) efficiently. Thus, the new method makes one-pot ketone synthesis highly effective even with a 1:1 mixture of the coupling partners. The synthetic value of the new method is demonstrated with the C-C bond formation at the final stage of a convergent halichondrin-synthesis.
Editorial
Authors: Arun Kumar Arti
Published: July 2019

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Best practice for using ports and non-coring needles
Authors: York Nicola
Published: July 2019

Ports are predominately inserted into oncology patients, but their use is becoming increasingly popular for other indications, such as cystic fibrosis. These devices not only provide patients and health professionals with reliable vascular access, but also preserve vessel health for future use. This article explores the additional equipment required to be able to access ports. It reiterates the need for education on the use of these devices, as this will help increase their longevity
Mobilising knowledge in public health: reflections on ten years of collaborative working in Fuse, the Centre for Translational Research in Public Health
Authors: van der Graaf Peter , Cheetham Mandy , Lake Amelia , Welford Mark , Rushmer Rosemary , Shucksmith Janet , Rhodes Avril
Published: July 2019

Background:

Fuse was established in 2008 as one of five public health research centres of excellence in the UK funded by the UK Clinical Research Centres collaboration. The centre works across five universities in the North East of England. This is an innovative collaboration and enables the pooling of research expertise. A prime focus of the centre is not just the production of excellent research, but also its translation into usable evidence, a dual focus that remains uncommon.

Aims/objectives:

This practice paper outlines Fuse’s approach to knowledge exchange (KE) by reflecting on ten years of collaborative research between academics and policy and practice partners in the North East of England. We will describe the principles and assumption underlying our approach and outline a conceptual model of four steps in Fuse’s KE process to develop collaborative research and achieve meaningful impact on policy and practice.

Key conclusions:

Our model describes a fluid and dynamic approach to knowledge exchange broken down in four steps in the KE process that are concurrent, iterative and vary in intensity over time: awareness raising; knowledge sharing; making evidence fit for purpose; and supporting uptake and implementation of evidence. These steps support the relational context of KE. Relationship building and maintenance is essential for all stages of KE to develop trust and explore the meaning and usefulness of evidence in a multi-directional information flow that supports the co-creating and application of evidence.
Emersive storytelling: An exploration of animation and the fourth wall as a tool for critical thinking
Authors: Wijers Eva
Published: July 2019

The term ‘emersive storytelling’ explores the positive effects of breaking the fourth wall and the special role of animation in doing so. The word ‘emersive’ is coined by the author of this article in order to discuss a method of storytelling in which the fictionality of the medium is acknowledged, derived from the verb ‘to emerge’: to come forth into view from concealment or obscurity. While immersive storytelling strives to totally engage the viewer, emersive storytelling acknowledges its own fiction and, thus, the inherent so-called ‘fourth wall’ (the fictional wall between the medium and the audience). This creates two effects: Brecht’s distancing effect and, conversely, what the author calls a ‘closeness effect’. Brecht’s distancing effect addresses the conscious intellectual connection the audience makes with the medium when the fourth wall is broken. Contrastingly, and complimentarily, as the author argues, the closeness effect describes the empathy an audience feels for characters even if the suspension of disbelief is broken. Emersive storytelling demands active participation from the viewer and triggers critical thinking both about the message of the story and about the medium itself. Animation is a self-reflective medium and its ability to reveal its own unreality and use this as a storytelling tool makes it well-suited for emersive storytelling. Several short case studies within this article will support this idea. In the last section, the article briefly looks into the future; with ever-more realistic-looking virtual reality and the rise of artificial intelligence, it might seem as though the fourth wall is disappearing. However, emersive storytelling can create ther distance required for critical reflection and help us reason with our relationship to these technologies. The paradox of the fourth wall is not one to be solved by immersing the viewer further and further, but one to be embraced and put to use emersively.
Intrinsic risk factors for gross motor delay in children aged 6-24 months
Authors: Hanrahan Joanna Erin , Mangunatmadja Irawan
Published: July 2019

Background. Gross motor is one of the skill domain with the highest parental concern as mastering it determines the autonomy of a child. Several internal risk factors including perinatal asphyxia, prematurity, low birth weight, wide fontanelle, and microcephaly have been studied in predicting gross motor delay with varied results. This study is made to arrange a strategic intervention on the prevention of delayed development.

Objective. To evaluate perinatal asphyxia, gestation age <37 weeks, birth weight <2500 grams, microcephaly, and wide fontanelle as predictors of gross motor delay in children aged 6-24 months.

Methods. A case control study design was used. Data collection was conducted by direct assessment of gross motor skill and parents’ interview in Cipto Mangunkusumo National Hospital and Anakku Clinic, South Jakarta. Children with gross motor delay were included in the case group and children with normal gross motor were included in the control group. Data was analyzed using bivariate and multivariate analysis with a statistical significance value of P<0.05 and 95% confidence intervals.

Results. One hundred and twenty-six subjects were studied, with 63 children in the case group and 63 children in the control group. Baseline characteristics of subjects were similar between the two groups. Microcephaly and gestation age <37 weeks were predictors of gross motor delay [(aOR 4.613 (95% CI 95 2.023 to 10.521, P<0.001) and (aOR 3.668 (95% CI 1.153 to 11.673, P=0.028), respectively].

Conclusion. Microcephaly and gestation age <37 weeks are significant predictors of gross motor delay in children aged 6-24 months.
Predictors of early growth failure in preterm, very low birth weight infants during hospitalization
Authors: Leksomono Noviyani , Sutomo Retno , Haksari Ekawaty Lutfia
Published: July 2019

Background Preterm, very low birth weight (VLBW) infants experience intrauterine nutritional deficits and perinatal comorbidities that may impair early growth parameters. Early growth failure has detrimental effects on later growth and neurodevelopment in childhood.
Objective To analyze predictors of early growth failure in preterm, VLBW infants and differences in early growth parameters between small-for-gestational age (SGA) and appropriate-for-gestational age (AGA) infants.
Methods This retrospective cohort study was conducted at Dr. Sardjito Hospital, Yogyakarta from 2011 to 2016. Subjects were preterm infants, with birth weights of 1,000-1,499 g. Twins, those who died during hospitalization, were discharged against medical advice, or had incomplete medical records were excluded. Adequate intrauterine growth was determined by the Lubchenco table criteria. Growth parameters and perinatal comorbidities were collected from medical records. Growth failure was defined as discharge weight less than 10th percentile of the Fenton growth curve. Bivariate and multivariate analysis were used to analyze potential predictive factors of early growth failure.
Results Of 646 preterm, VLBW infants during the study period, 398 were excluded. Respiratory distress and SGA were predictors of early growth failure (AOR 6.94; 95%CI 2.93 to 16.42 and AOR 34.44; 95%CI 7.79 to 152.4, respectively). Mean weight velocities in SGA and AGA infants were not significantly different [16.5 (SD 5.9) and 17.5 (SD 5.3) g/kg/day, respectively; (P=0.25)]. Median time to regain, time to reach full feeding, and time to reach 120 kcal/kg/day were also not significantly different between SGA and AGA infants.
Conclusions SGA and respiratory distress are predictors of early growth failure in preterm, VLBW infants during hospitalization. The SGA infants grow slower than AGA infants.
Correlation of serum level of albumin with platelet count and platelet aggregation assessed by adenosine diphosphate agonist in children with nephrotic syndrome
Authors: Nainggolan Andar Laura , Sudarwati Sri , Hilmanto Dany
Published: July 2019

Background Nephrotic syndrome (NS) is the most common renal disease among children, and contributes to life-threatening complications such as thromboembolic disease. Platelets are considered to be important agents in thrombotic events among NS patients. The gold standard assessment for platelet aggregation is the use of adenosine diphosphate (ADP) agonist, however, it is expensive and not accessible in smaller health facilities. Thus, other thrombosis parameters are needed. Previous studies suggested that low albumin increased the risk of thrombosis in NS patients.

Objective To assess for a possible correlation between albumin level and platelet count as well as platelet aggregation.

Methods This cross-sectional study was conducted in children with nephrotic syndrome who were admitted to the Pediatric Nephrology Department in Dr. Hasan Sadikin General Hospital, Bandung, West Java, from November 2017 to March 2018. Subjects were selected by consecutive sampling. Serum albumin, platelet count, and platelet aggregation were measured. Statistical analysis was conducted by Spearman’s test.

Results A total of 32 patients participated in the study, with mean age of 109 (SD 7.4) months. Most subjects were male (56%). Subjects’ mean serum albumin level was 2.06 (SD 1.23) g/dL; mean platelet count was 453,062.5 (SD 187,443.90)/mm3; and mean platelet aggregation values for ADP agonist concentrations of 10, 5, 2.5, and 1 mM were 86.8 (SD 8.63)%, 82.4 (SD 15.33)%, 66.6 (SD 24.90)%, 34.95 (SD 31.69)%, respectively. Partial correlation analysis revealed significant negative associations between albumin and platelet count as well as platelet aggregation assessed with 1 mM of ADP concentration (P<0.001), with Spearman correlation coefficients of -0.641 and -0.634, respectively.

Conclusion Serum albumin level had a moderately negative correlation with platelet count and platelet aggregation value.
Intragastric Balloons: An Emerging Therapy for Nonalcoholic Steatohepatitis and Fibrosis?
Authors: Jirapinyo Pichamol , Cenaj Odise , Ryou Marvin , Thompson Christopher C.
Published: July 2019

Weight loss through lifestyle intervention remains the mainstay treatment for nonalcoholic steatohepatitis (NASH). Nevertheless, only a minority of patients undergoing lifestyle intervention are able to achieve the weight loss threshold that reverses NASH histologic features. This case report demonstrates a minimally invasive method of treating NASH using an intragastric balloon. With endoscopic ultrasound-guided liver biopsy at the time of intragastric balloon removal, we demonstrate a significant improvement in NASH histologic features including steatosis, ballooning, lobular inflammation, and fibrosis. This endoscopic method may offer an alternative solution to patients with NASH who fail lifestyle intervention.
Association of HIF-1α and NDRG2 expression with EMT in gastric cancer tissues
Authors: Wang Ren-Xiang , Ou Xia-Wan , Kang Ma-Fei , Zhou Zu-Ping
Published: July 2019

Objective

This study aims to investigate the differences in the expression of hypoxia-inducible factor-1α (HIF-1α), N-myc downstream-regulated gene 2 (NDRG2) and epithelial mesenchymal transition (EMT)-related proteins in normal gastric tissues, gastric cancer tissues and lymph node metastasis.

Methods

Immunohistochemistry was used to detect the expression of HIF-1α, NDRG2, E-cadherin, Snail and Twist in normal gastric tissues, gastric cancer tissues and lymph node metastasis.

Results

In normal gastric tissues, HIF-1α was not expressed, NDRG2 was highly expressed. There was a significant between the expression of NDRG2 and Snail, as well as of NDRG2 and Twist. In gastric cancer tissues, there was no statistically difference between the expression of HIF-1α and E-cadherin, NDRG2 and E-cadherin. However, there was a significant difference in expression between the expression of HIF-1α and Snail, HIF-1α and Twist, NDRG2 and Snail, and NDRG2 and Twist. In lymph node metastasis tissues, we show that HIF-1α was highly expressed, while NDRG2 was not, and the difference between the expression of HIF-1α and E-cadherin, HIF-1α and Snail, HIF-1α and Twist was not significant.

Conclusion

HIF-1α may promote EMT, possibly by inhibiting the expression of NDRG2.
Identification of Leaf Rust Resistance Genes in Selected Wheat Cultivars and Development of Multiplex PCR
Authors: Tomkowiak Agnieszka , Skowrońska Roksana , Buda Alicja , Kurasiak-Popowska Danuta , Nawracała Jerzy , Kowalczewski Przemysław Łukasz , Pluta Mateusz , Radzikowska Dominika
Published: July 2019

Ten leading wheat cultivars originating from the Plant Breeding and Acclimatization Institute (IHAR) - National Research Institute (Poland) and the Department of Gene Bank (Czech Republic) were used to establish a field experiment in 2017 and 2018 at the Dłoń Experimental Farm. The analyzed wheat genotypes were characterized by diversified field resistance to leaf rust. Jubilatka, Thatcher and Sparta were the most resistant cultivars in field conditions in both 2017 and 2018. The aim of the work was to identify the Lr11, L13, Lr16 and Lr26 genes encoding resistance to leaf rust using molecular SSR markers (wmc24, wmc261, Xgwm630, Xwmc764 and P6M12) and to develop multiplex PCR conditions to accelerate identification of these genes. Markers of three leaf rust resistance genes have been identified simultaneously in these cultivars. Jubilatka, Thatcher and Sparta cultivars may serve as a good source of the analyzed leaf rust resistance genes. In addition, multiplex PCR conditions have been developed for the simultaneous identification of the Lr11 and Lr16 and Lr11 and Lr26 gene pairs.
The diagnostic efficacy of thrombelastography (TEG) in patients with preeclampsia and its association with blood coagulation
Authors: Lidan He , Jianbo Wu , Liqin Gao , Jifen Hu , Lin Lu , Xiuyan Wu
Published: July 2019

Objective

The aim of this study was to investigate the diagnostic efficacy of thrombelastography (TEG) in patients with preeclampsia.

Methods

One hundred and seventeen pregnant women were recruited from Department of Obstetrics and Gynecology of 1st affiliated Hospital of Fujian Medical University. Of the 117 patients, 59 were normal late gestation (control group), 32 were mild preeclampsia and other 26 cases were severe preeclampsia. All the patients were received thrombelastography (including: K time, Reaction time, Clot angel, MA value, CI value) and blood coagulation examination (including: PT, APTT, Fib, TT, D-dimer and AT-III).

Results

The R time, K time, Coagulation Index value and Clot Angle in preeclampsia group were significant different between control and preeclampsia groups with statistical difference (p<0.05). Moreover, the R and K time value in severe preeclampsia group were significant higher than those of control groups (p<0.05); however, the Coagulation Index value and Clot Angle in severe preeclampsia group were significant higher than those of mild preeclampsia group with statistical difference (p<0.05). Coagulation Index had the highest diagnostic sensitivity [87.93 (76.70-95.01) %] and specificity [83.83 (79.17-96.18)%] compared to other parameters with the AUC of 0.94 (0.90-0.98). The K time and the Coagulation Index had the highest diagnostic sensitivity (96.15%) and specificity (0.75%) respectively with the AUC of 0.68 and 0.75 respectively in differential diagnosis of severe preeclampsia from mild preeclampsia. However, there were no statistical difference in the aspects of platelet count and parameters relevant to coagulation test for the control, mild and sever preeclampsia groups(p>0.05).

Conclusion

TEG provides more accurate information in monitoring the blood coagulation of preeclampsia patients and can be used as a reliable marker for assessing the severity of preeclampsia.