bluuebunny/crossref_metadata_2025 huggingface dataset:
Cardiovascular Disease in Obstructive Sleep Apnea: Putative Contributions of Mineralocorticoid Receptors
Authors: Badran Mohammad , Bender Shawn B. , Gozal David
Published: January 2023

Obstructive sleep apnea (OSA) is a chronic and highly prevalent condition that is associated with oxidative stress, inflammation, and fibrosis, leading to endothelial dysfunction, arterial stiffness, and vascular insulin resistance, resulting in increased cardiovascular disease and overall mortality rates. To date, OSA remains vastly underdiagnosed and undertreated, with conventional treatments yielding relatively discouraging results for improving cardiovascular outcomes in OSA patients. As such, a better mechanistic understanding of OSA-associated cardiovascular disease (CVD) and the development of novel adjuvant therapeutic targets are critically needed. It is well-established that inappropriate mineralocorticoid receptor (MR) activation in cardiovascular tissues plays a causal role in a multitude of CVD states. Clinical studies and experimental models of OSA lead to increased secretion of the MR ligand aldosterone and excessive MR activation. Furthermore, MR activation has been associated with worsened OSA prognosis. Despite these documented relationships, there have been no studies exploring the causal involvement of MR signaling in OSA-associated CVD. Further, scarce clinical studies have exclusively assessed the beneficial role of MR antagonists for the treatment of systemic hypertension commonly associated with OSA. Here, we provide a comprehensive overview of overlapping mechanistic pathways recruited in the context of MR activation- and OSA-induced CVD and propose MR-targeted therapy as a potential avenue to abrogate the deleterious cardiovascular consequences of OSA.
The SMN Complex at the Crossroad between RNA Metabolism and Neurodegeneration
Authors: Faravelli Irene , Riboldi Giulietta M. , Rinchetti Paola , Lotti Francesco
Published: January 2023

In the cell, RNA exists and functions in a complex with RNA binding proteins (RBPs) that regulate each step of the RNA life cycle from transcription to degradation. Central to this regulation is the role of several molecular chaperones that ensure the correct interactions between RNA and proteins, while aiding the biogenesis of large RNA-protein complexes (ribonucleoproteins or RNPs). Accurate formation of RNPs is fundamentally important to cellular development and function, and its impairment often leads to disease. The survival motor neuron (SMN) protein exemplifies this biological paradigm. SMN is part of a multi-protein complex essential for the biogenesis of various RNPs that function in RNA metabolism. Mutations leading to SMN deficiency cause the neurodegenerative disease spinal muscular atrophy (SMA). A fundamental question in SMA biology is how selective motor system dysfunction results from reduced levels of the ubiquitously expressed SMN protein. Recent clarification of the central role of the SMN complex in RNA metabolism and a thorough characterization of animal models of SMA have significantly advanced our knowledge of the molecular basis of the disease. Here we review the expanding role of SMN in the regulation of gene expression through its multiple functions in RNP biogenesis. We discuss developments in our understanding of SMN activity as a molecular chaperone of RNPs and how disruption of SMN-dependent RNA pathways can contribute to the SMA phenotype.
Anatomical Distribution of Ultraviolet Radiation Depends on Phototherapy Unit Design and on Personal Height and Body Mass
Authors: Wulf Hans Christian , Philipsen Peter A. , Heydenreich Jakob
Published: January 2023

Phototherapy using ultraviolet radiation (UVR) treatment units of various designs is common in dermatology. The anatomical distribution of UVR should be even, regardless of individual body shapes. Using electronic dosimeters, we measured the irradiance at 31 body sites on 12 persons of different heights and body mass (BMI). Five different treatment unit designs were tested: cabinet units with standing patients, units with patients lying down, and a unit where patients rotated in front of flatly arranged UVR tubes. In treatment units with short tubes, persons taller than 170 cm received low irradiance on the face, neck, and shoulders. In cabinet-type units, higher BMI lowered the irradiance on the chest and belly. The relative standard deviation (RSD) of irradiance was smallest for the rotating unit, and for the unit with patients lying down while irradiated from above only. A higher RSD was found in the unit designs where patients stood inside cabinets, and where patients lay down and were simultaneously irradiated from both sides. In general, longer tubes lower the overall RSD. The irradiance of the different body areas is about 60% of the measured calibration values, but to avoid provoking any erythema, the treatment dose can only be increased by 10%.
A Survey on RISC-V-Based Machine Learning Ecosystem
Authors: Kalapothas Stavros , Galetakis Manolis , Flamis Georgios , Plessas Fotis , Kitsos Paris
Published: January 2023

In recent years, the advancements in specialized hardware architectures have supported the industry and the research community to address the computation power needed for more enhanced and compute intensive artificial intelligence (AI) algorithms and applications that have already reached a substantial growth, such as in natural language processing (NLP) and computer vision (CV). The developments of open-source hardware (OSH) and the contribution towards the creation of hardware-based accelerators with implication mainly in machine learning (ML), has also been significant. In particular, the reduced instruction-set computer-five (RISC-V) open standard architecture has been widely adopted by a community of researchers and commercial users, worldwide, in numerous openly available implementations. The selection through a plethora of RISC-V processor cores and the mix of architectures and configurations combined with the proliferation of ML software frameworks for ML workloads, is not trivial. In order to facilitate this process, this paper presents a survey focused on the assessment of the ecosystem that entails RISC-V based hardware for creating a classification of system-on-chip (SoC) and CPU cores, along with an inclusive arrangement of the latest released frameworks that have supported open hardware integration for ML applications. Moreover, part of this work is devoted to the challenges that are concerned, such as power efficiency and reliability, when designing and building application with OSH in the AI/ML domain. This study presents a quantitative taxonomy of RISC-V SoC and reveals the opportunities in future research in machine learning with RISC-V open-source hardware architectures.
The Applications of Metallacycles and Metallacages
Authors: Yin Changfeng , Du Jiaxing , Olenyuk Bogdan , Stang Peter , Sun Yan
Published: January 2023

Metallacycles and metallacages constitute a class of coordination compounds composed of metal ions and organic ligands. Because of their precise stoichiometry, the flexibility and viability of design, metallacycles and metallacages have attracted considerable attention as supramolecular assemblies. Various two-dimensional polygons, three-dimensional polyhedra, and other nanoscale materials have been constructed and applied. The highly diverse structures, sizes, and shapes endow metallacycles and metallacages with unique physical and chemical properties and make them suitable for various applications such as encapsulation, separation, catalysis, and biological science. Herein, we review the recent developments in various metallacycles and metallacages in different fields. The text highlights biomedical applications involving molecular recognition and binding, antibacterial activity, and especially cancer diagnosis and treatment, including imaging, chemotherapy, PDT, and PTT.
Genetically Depauperate and Still Successful: Few Multilocus Genotypes of the Introduced Parthenogenetic Weevil Naupactus cervinus (Coleoptera: Curculionidae) Prevail in the Continental United States
Authors: Rodriguero Marcela S. , Confalonieri Viviana A. , Mackay Smith Ava , Dornon Mary Kate , Zagoren Eleanor , Palmer Alice , Sequeira Andrea S.
Published: January 2023

Naupactus cervinus is a parthenogenetic weevil native to South America that is currently distributed worldwide. This flightless species is polyphagous and capable of modifying gene expression regimes for responding to stressful situations. Naupactus cervinus was first reported in the continental United States in 1879 and has rapidly colonized most of the world since. Previous studies suggested that an invader genotype successfully established even in areas of unsuitable environmental conditions. In the present work, we analyze mitochondrial and nuclear sequences from 71 individuals collected in 13 localities across three states in the southern US, in order to describe the genetic diversity in this area of introduction that has not yet been previously studied. Our results suggest that 97% of the samples carry the most prevalent invader genotype already reported, while the rest shows a close mitochondrial derivative. This would support the hypothesis of a general purpose genotype, with parthenogenesis and its associated lack of recombination maintaining the linkage of genetic variants capable of coping with adverse conditions and enlarging its geographical range. However, demographic advantages related to parthenogenetic reproduction as the main driver of geographic expansion (such as the foundation of a population with a single virgin female) cannot be ruled out. Given the historical introduction records and the prevalence of the invader genotype, it is possible that the continental US may act as a secondary source of introductions to other areas. We propose that both the parthenogenesis and scarce genetic variation in places of introduction may, in fact, be an asset that allows N. cervinus to thrive across a range of environmental conditions.
Bolwig Organ and Its Role in the Photoperiodic Response of Sarcophaga similis Larvae
Authors: Hirata Kazuné , Shiga Sakiko
Published: January 2023

Flesh-fly Sarcophaga similis larvae exhibit a photoperiodic response, in which short days induce pupal diapause for seasonal adaptation. Although the spectral sensitivity of photoperiodic photoreception is known, the photoreceptor organ remains unclear. We morphologically identified the Bolwig organ, a larval-photoreceptor identified in several other fly species, and examined the effects of its removal on the photoperiodic response in S. similis. Backfill-staining and embryonic-lethal-abnormal-vision (ELAV) immunohistochemical-staining identified ~34 and 38 cells, respectively, in a spherical body at the ocular depression of the cephalopharyngeal skeleton, suggesting that the spherical body is the Bolwig organ in S. similis. Forward-fill and immunohistochemistry revealed that Bolwig-organ neurons terminate in the vicinity of the dendritic fibres of pigment-dispersing factor-immunoreactive and potential circadian-clock neurons in the brain. After surgical removal of the Bolwig-organ regions, diapause incidence was not significantly different between short and long days, and was similar to that in the insects with an intact organ, under constant darkness. However, diapause incidence was not significantly different between the control and Bolwig-organ-removed insects for each photoperiod. These results suggest that the Bolwig organ contributes partially to photoperiodic photoreception, and that other photoreceptors may also be involved.
Prediction of Functional Outcome in Stroke Patients with Proximal Middle Cerebral Artery Occlusions Using Machine Learning Models
Authors: Ozkara Burak B. , Karabacak Mert , Hamam Omar , Wang Richard , Kotha Apoorva , Khalili Neda , Hoseinyazdi Meisam , Chen Melissa M. , Wintermark Max , Yedavalli Vivek S.
Published: January 2023

At present, clinicians are expected to manage a large volume of complex clinical, laboratory, and imaging data, necessitating sophisticated analytic approaches. Machine learning-based models can use this vast amount of data to create forecasting models. We aimed to predict short- and medium-term functional outcomes in acute ischemic stroke (AIS) patients with proximal middle cerebral artery (MCA) occlusions using machine learning models with clinical, laboratory, and quantitative imaging data as inputs. Included were consecutive AIS patients with MCA M1 and proximal M2 occlusions. The XGBoost, LightGBM, CatBoost, and Random Forest were used to predict the outcome. Minimum redundancy maximum relevancy was used for selecting features. The primary outcomes were the National Institutes of Health Stroke Scale (NIHSS) shift and the modified Rankin Score (mRS) at 90 days. The algorithm with the highest area under the receiver operating characteristic curve (AUROC) for predicting the favorable and unfavorable outcome groups at 90 days was LightGBM. Random Forest had the highest AUROC when predicting the favorable and unfavorable groups based on the NIHSS shift. Using clinical, laboratory, and imaging parameters in conjunction with machine learning, we accurately predicted the functional outcome of AIS patients with proximal MCA occlusions.
Acute Ischemic Stroke and Transient Ischemic Attack in ST-Segment Elevation Myocardial Infarction Patients Who Underwent Primary Percutaneous Coronary Intervention
Authors: Murakami Tsukasa , Sakakura Kenichi , Jinnouchi Hiroyuki , Taniguchi Yousuke , Tsukui Takunori , Watanabe Yusuke , Yamamoto Kei , Seguchi Masaru , Wada Hiroshi , Fujita Hideo
Published: January 2023

Background: Acute ischemic stroke (AIS) is a rare but critical complication following ST-elevation myocardial infarction (STEMI). The risk of AIS or transient ischemic attack (TIA) may be amplified by invasive procedures, including primary percutaneous coronary intervention (PCI). This study aimed to investigate the factors associated with in-hospital AIS/TIA in patients with STEMI who required primary PCI. Methods: We included 941 STEMI patients who underwent primary PCI and divided them into an AIS/TIA group (n = 39) and a non-AIS/TIA group (n = 902), according to new-onset AIS/TIA. The primary interest was to find the factors associated with AIS/TIA by multivariate logistic regression analysis. We also compared clinical outcomes between the AIS/TIA and non-AIS/TIA groups. Results: The incidence of in-hospital deaths was significantly higher in the AIS/TIA group (46.2%) than in the non-AIS/TIA group (6.3%) (p < 0.001). Multivariate analysis revealed that cardiogenic shock (OR 3.228, 95% CI 1.492–6.986, p = 0.003), new-onset atrial fibrillation (AF) (OR 2.280, 95% CI 1.033–5.031, p = 0.041), trans-femoral approach (OR 2.336, 95% CI 1.093–4.992, p = 0.029), use of ≥4 catheters (OR 3.715, 95% CI 1.831–7.537, p < 0.001), and bleeding academic research consortium (BARC) type 3 or 5 bleeding (OR 2.932, 95% CI 1.256–6.846, p = 0.013) were significantly associated with AIS/TIA. Conclusion: In STEMI patients with primary PCI, new-onset AIS/TIA was significantly associated with cardiogenic shock, new-onset AF, trans-femoral approach, the use of ≥4 catheters, and BARC type 3 or 5 bleeding. We should recognize these modifiable and unmodifiable risk factors for AIS/TIA in the treatment of STEMI.
The Emerging Role of Virtual Reality as an Adjunct to Procedural Sedation and Anesthesia: A Narrative Review
Authors: Hitching Rita , Hoffman Hunter G. , Garcia-Palacios Azucena , Adamson Maheen M. , Madrigal Esmeralda , Alhalabi Wadee , Alhudali Ahad , Sampaio Mariana , Peterson Barry , Fontenot Miles R. , Mason Keira P.
Published: January 2023

Over the past 20 years, there has been a significant reduction in the incidence of adverse events associated with sedation outside of the operating room. Non-pharmacologic techniques are increasingly being used as peri-operative adjuncts to facilitate and promote anxiolysis, analgesia and sedation, and to reduce adverse events. This narrative review will briefly explore the emerging role of immersive reality in the peri-procedural care of surgical patients. Immersive virtual reality (VR) is intended to distract patients with the illusion of “being present” inside the computer-generated world, drawing attention away from their anxiety, pain, and discomfort. VR has been described for a variety of procedures that include colonoscopies, venipuncture, dental procedures, and burn wound care. As VR technology develops and the production costs decrease, the role and application of VR in clinical practice will expand. It is important for medical professionals to understand that VR is now available for prime-time use and to be aware of the growing body in the literature that supports VR.
Non-Alcoholic Fatty Liver Disease in Patients with Polycystic Ovary Syndrome: A Systematic Review, Meta-Analysis, and Meta-Regression
Authors: Manzano-Nunez Ramiro , Santana-Dominguez Marta , Rivera-Esteban Jesus , Sabiote Clara , Sena Elena , Bañares Juan , Tacke Frank , Pericàs Juan M.
Published: January 2023

Background: The metabolic effects of polycystic ovary syndrome (PCOS) may increase the risk of non-alcoholic fatty liver disease (NAFLD). However, the burden of NAFLD in PCOS has not been unequivocally defined. This systematic review (SR), meta-analysis (MA) assessed NAFLD’s prevalence, and risk factors in patients with PCOS. Methods: A literature search was performed in MEDLINE, Scopus, and Scielo. First, we performed a MA of proportions to estimate the prevalence of NAFLD in PCOS. Second, we performed meta-analyses of precalculated adjusted odds ratios to examine NAFLD risk factors. Finally, we performed a meta-regression to model how the estimated prevalence changed with changes in prespecified variables. Results: We identified 817 articles from the database searches. Thirty-six were included. MA of proportions found a pooled NAFLD prevalence of 43% (95% CI, 35–52%) with high heterogeneity (I2 = 97.2%). BMI, waist circumference, ALT values, HOMA-IR values, free androgen index levels, hyperandrogenism, and triglycerides were associated with significantly higher risk-adjusted odds of NAFLD among patients with PCOS. Meta-regression showed that rises in NAFLD prevalence were mediated through increases in metabolic syndrome prevalence and higher levels of HOMA-IR, free androgen index, and total testosterone. Conclusion: The prevalence of NAFLD (43%) among PCOS patients is high despite their average young age, with several metabolic and PCOS-specific factors influencing its occurrence. Screening programs may aid in detecting metabolic-associated fatty liver disease and prevent its consequences. Further work is required to establish the burden of liver-related outcomes once NAFLD has progressed in the PCOS population.
Short-Term Outcomes and Risk Factors of In-Hospital Mortality in Patients Suffering Acute Mesenteric Ischemia after Cardiac Surgery: Role of Opioids and Lactic Acid
Authors: Krasivskyi Ihor , Djordjevic Ilija , Tayeh Mahmoud , Eghbalzadeh Kaveh , Ivanov Borko , Avgeridou Soi , Gerfer Stephen , Gaisendrees Christopher , Suhr Laura , Sabashnikov Anton , Rustenbach Christian Jörg , Mader Navid , Doerr Fabian , Wahlers Thorsten
Published: January 2023

Acute mesenteric ischemia (AMI) is associated with poor clinical results after cardiac surgery. The aim of this study was to analyse the influence of AMI on short-term outcomes and all relevant risk factors of in-hospital mortality after cardiac surgery. Moreover, we aimed to investigate the role of opioids and lactic acid in the detection and prevention of AMI. Between August 2011 and September 2015, 176 consecutive patients with gastrointestinal complications after undergoing open-heart surgery were identified and included in this study. All patients were divided into two groups: AMI group (n = 39) and non-AMI group (n = 137). In terms of comorbidities, the groups were fairly equal and showed no significant differences. Dialysis was significantly higher (p < 0.001) in patients that suffered from AMI. Moreover, gastro-intestinal symptoms such as muscular defense (p = 0.004) and the laparotomy rate (p < 0.001) were significantly higher in the AMI group. Likewise, in-hospital mortality (p < 0.001) was significantly higher in patients with detected AMI. Univariate (p < 0.001) and multivariate analysis (p = 0.025) of both groups revealed that lactic acid value >2 mmol/L and present treatment with opioids are independent combined predictors of mesenteric ischemia in patients after undergoing cardiac surgery. Moreover, multivariate analysis showed peripheral vascular disease (p = 0.004), dialysis (p = 0.010), and septic shock (p = 0.003) as relevant predictors of in-hospital mortality. Prolonged analgetic treatment with opioids and sudden increase of lactic acid levels are independent combined predictors of mesenteric ischemia in patients after undergoing cardiac surgery. Furthermore, peripheral vascular disease, dialysis, and septic shock are relevant predictors for in-hospital mortality.
Esophagogastroduodenoscopy Outcomes Variated by the Time of the Day: A Single-Center Experience
Authors: Zhang Zhang , Chen Xiaojia , Wang Haizhou , Nie Haihang , Wang Fan , Zhao Qiu , Fang Jun
Published: January 2023

(1) Background: To assess whether the start time influences the outcomes of esophagogastroduodenoscopy (EGD). (2) Methods: We retrospectively analyzed the clinical data of patients who underwent EGD between January 2021 and December 2021 in our endoscopy center. The EGD were divided into three shifts, according to the start time. The lesion detection rate (LDR) and endoscopy biopsy rate (EBR) were used to evaluate the quality of the EGD. (3) Results: A total of 14,597 procedures were included in this study. The LDR of shift 2 was significantly lower than that of shift 1 (62.4% vs. 58.5%; p < 0.001). The EBR of shift 1 (37.4% vs. 31.5%; p < 0.001) and shift 3 (35.5% vs. 31.5%; p = 0.024) were significantly higher than that of shift 2; the EBR in shift 1 did not differ significantly from shift 3 (p = 0.280). The multivariable analysis for the EGD performed before 14:00 demonstrated a graded decrease in the LDR and EBR after adjusting the confounders (p < 0.001). (4) Conclusion: In a continuous working period, the lesion detection and biopsy submission of EGD are superior to those in the first three hours compared to the last three hours; the LDR and EBR decreased as the day progressed, probably due to the endoscopists’ fatigue.
Assessment of Clinical Indicators Registered on Admission to the Hospital Related to Mortality Risk in Cancer Patients with COVID-19
Authors: Szewczyk-Dąbrowska Alina , Banasik Mirosław , Dąbrowska Krystyna , Kujawa Krzysztof , Bombala Wojciech , Sebastian Agata , Matera-Witkiewicz Agnieszka , Krupińska Magdalena , Grata-Borkowska Urszula , Sokołowski Janusz , Kiliś-Pstrusińska Katarzyna , Adamik Barbara , Doroszko Adrian , Kaliszewski Krzysztof , Pomorski Michał , Protasiewicz Marcin , Jankowska Ewa A. , Madziarska Katarzyna
Published: January 2023

Background: Oncology patients are a particularly vulnerable group to the severe course of COVID-19 due to, e.g., the suppression of the immune system. The study aimed to find links between parameters registered on admission to the hospital and the risk of later death in cancer patients with COVID-19. Methods: The study included patients with a reported history of malignant tumor (n = 151) and a control group with no history of cancer (n = 151) hospitalized due to COVID-19 between March 2020 and August 2021. The variables registered on admission were divided into categories for which we calculated the multivariate Cox proportional hazards models. Results: Multivariate Cox proportional hazards models were successfully obtained for the following categories: Patient data, Comorbidities, Signs recorded on admission, Medications used before hospitalization and Laboratory results recorded on admission. With the models developed for oncology patients, we identified the following variables that registered on patients’ admission were linked to significantly increased risk of death. They are: male sex, presence of metastases in neoplastic disease, impaired consciousness (somnolence or confusion), wheezes/rhonchi, the levels of white blood cells and neutrophils. Conclusion: Early identification of the indicators of a poorer prognosis may serve clinicians in better tailoring surveillance or treatment among cancer patients with COVID-19.
Integrative and Mechanistic Approach to the Hair Growth Cycle and Hair Loss
Authors: Natarelli Nicole , Gahoonia Nimrit , Sivamani Raja K.
Published: January 2023

The hair cycle is composed of four primary phases: anagen, catagen, telogen, and exogen. Anagen is a highly mitotic phase characterized by the production of a hair shaft from the hair follicle, whereas catagen and telogen describe regression and the resting phase of the follicle, respectively, ultimately resulting in hair shedding. While 9% of hair follicles reside in telogen at any time, a variety of factors promote anagen to telogen transition, including inflammation, hormones, stress, nutritional deficiency, poor sleep quality, and cellular division inhibiting medication. Conversely, increased blood flow, direct stimulation of the hair follicle, and growth factors promote telogen to anagen transition and subsequent hair growth. This review seeks to comprehensively describe the hair cycle, anagen and telogen balance, factors that promote anagen to telogen transition and vice versa, and the clinical utility of a variety of lab testing and evaluations. Ultimately, a variety of factors impact the hair cycle, necessitating a holistic approach to hair loss.
Assessing Auditory Processing in Children with Listening Difficulties: A Pilot Study
Authors: Omidvar Shaghayegh , Duquette-Laplante Fauve , Bursch Caryn , Jutras Benoît , Koravand Amineh
Published: January 2023

Background: Auditory processing disorders (APD) may be one of the problems experienced by children with listening difficulties (LiD). The combination of auditory behavioural and electrophysiological tests could help to provide a better understanding of the abilities/disabilities of children with LiD. The current study aimed to quantify the auditory processing abilities and function in children with LiD. Methods: Twenty children, ten with LiD (age = 8.46; SD = 1.39) and ten typically developing (TD) (age = 9.45; SD = 1.57) participated in this study. All children were evaluated with auditory processing tests as well as with attention and phonemic synthesis tasks. Electrophysiological measures were also conducted with click and speech auditory brainstem responses (ABR). Results: Children with LiD performed significantly worse than TD children for most behavioural tasks, indicating shortcomings in functional auditory processing. Moreover, the click-ABR wave I amplitude was smaller, and the speech-ABR waves D and E latencies were longer for the LiD children compared to the results of TD children. No significant difference was found when evaluating neural correlates between groups. Conclusions: Combining behavioural testing with click-ABR and speech-ABR can highlight functional and neurophysiological deficiencies in children with learning and listening issues, especially at the brainstem level.
Surgical Outcomes of Lensectomy-Vitrectomy with Primary Intraocular Lens Implantation in Children with Bilateral Congenital Cataracts
Authors: Li Hongzhe , Lin Xiaolei , Liu Xin , Zhou Xiyue , Yang Tianke , Fan Fan , Luo Yi
Published: January 2023

In this study, we evaluated the long-term surgical outcomes of lensectomy-vitrectomy with primary intraocular lens (IOL) implantation in children with bilateral congenital cataracts (CCs) and investigated the potential risk factors for low vision. A total of 148 eyes in 74 children who underwent lensectomy-vitrectomy with primary IOL implantation were enrolled in this study. The surgery age was 44.04 ± 14.60 months, with a follow-up period of 46.66 ± 14.34 months. The final BCVA was 0.24 ± 0.32 logMAR, and low vision was found in 22 eyes (14.9%). Postoperative complications requiring additional surgeries included VAO (4 eyes, 5.4%), IOL pupillary captures (2 eyes, 2.0%), iris incarceration (1 eye, 0.7%), and glaucoma (1 eye, 0.7%). A higher incidence of VAO and larger postoperative refractive error was observed in younger children (≤2 years old) than in elder children (>2 years old) (p = 0.003, p = 0.047, respectively). Final BCVA was affected by preexisting comorbidity (p < 0.001), cataract density (p < 0.001), cataract size (p = 0.020), occurrence of postoperative complications (p = 0.011), and ASE (p = 0.008). Multivariate analysis showed that denser cataracts (OR = 9.303, p = 0.035) and preexisting comorbidity (OR = 4.712, p = 0.004) were the significant predictors of low vision. In conclusion, lensectomy-vitrectomy with primary IOL implantation is an effective and safe treatment for CC. The long-term visual outcome is encouraging in children with bilateral CC undergoing this procedure with a low rate of postoperative complications requiring surgeries. Moreover, eyes with denser cataracts and preexisting comorbidity may have a high risk of low vision.
Prognostic Factors for Triple-Negative Breast Cancer with Residual Disease after Neoadjuvant Chemotherapy
Authors: Li Zhijun , Han Yiqun , Wang Jiayu , Xu Binghe
Published: January 2023

Valid factors to evaluate the prognosis of triple-negative breast cancer (TNBC) with residual disease after neoadjuvant chemotherapy (NAC) are still lacking. We performed this study to explore prognostic factors focusing on genetic alterations and clinicopathology features in non- pathologic complete response (pCR) TNBC patients. Patients initially diagnosed with early-stage TNBC, treated with NAC, and who had residual disease after primary tumor surgery at the China National Cancer Center during 2016 and 2020 were enrolled. Genomic analyses were performed by targeted sequencing for each tumor sample. Univariable and multivariable analyses were conducted to screen prognostic factors for the survival of patients. Fifty-seven patients were included in our study. Genomic analyses showed that TP53 (41/57, 72%), PIK3CA (12/57, 21%), and MET (7/57, 12%), and PTEN (7/57, 12%) alternations commonly occurred. The clinical TNM (cTNM) stage and PIK3CA status were independent prognostic factors of disease-free survival (DFS) (p < 0.001, p = 0.03). A prognostic stratification indicated that patients with clinical stages I &II possessed the best DFS, followed by those with clinical stage III & wild-type PIK3CA. In contrast, patients with clinical stage III & the PIK3CA mutation had the worst DFS. In TNBC patients with residual disease after NAC, prognostic stratification for DFS was observed by combining the cTNM stage and PIK3CA status.
RePlant Alfa: Integrating Google Earth Engine and R Coding to Support the Identification of Priority Areas for Ecological Restoration
Authors: Morales Narkis S. , Fernández Ignacio C. , Durán Leonardo P. , Pérez-Martínez Waldo A.
Published: January 2023

Land degradation and climate change are among the main threats to the sustainability of ecosystems worldwide. As a result, the restoration of degraded landscapes is essential to maintaining the functionality of ecosystems, especially those with greater social, economic, and environmental vulnerability. Nevertheless, policymakers are frequently challenged by deciding where to prioritize restoration actions, which usually includes dealing with multiple and complex needs under an always limited budget. If these decisions are not taken based on proper data and processes, restoration implementation can easily fail. In order to help decision-makers take informed decisions on where to implement restoration activities, we have developed a semiautomatic geospatial platform to prioritize areas for restoration activities based on ecological, social, and economic variables. This platform takes advantage of the potential to integrate R coding, Google Earth Engine cloud computing, and GIS visualization services to generate an interactive geospatial decision-maker tool for restoration. Here, we present a prototype version called “RePlant alpha”, which was tested with data from the Central Zone of Chile. This exercise proved that integrating R and GEE was feasible, and that the analysis with at least six indicators for a specific region was also feasible to implement even from a personal computer. Therefore, the use of a virtual machine in the cloud with a large number of indicators over large areas is both possible and practical.
Non-Invasive Prospection Techniques in the Cabo de Gata-Níjar Natural Park (Almería, Spain): Torregarcía’s Site
Authors: López-Medina María-Juana , de la Paz Román-Díaz María , García-Pardo Manuela , Aragón-Núñez Enrique , Calvillo-Ardila José-Antonio , Lagóstena-Barrios Lázaro G.
Published: January 2023

Along the Southeast coast of the Iberian Peninsula are numerous remains linked to the ancient purple exploitation destined for elaborating dyes. Our study focused on analysing the Torregarcía’s site (Almeria, Spain), which is set in the Cabo de Gata-Níjar Natural Park, a protected coastal space of huge ecological interest. Torregarcía was excavated in the 1980s. Despite its importance, it has remained invisible to the historiography of the last three decades due to the lack of scientific publications on the matter. The current archaeological works, performed by non-invasive prospection techniques, such as GPR, magnetometer or UAV, revealed the relevance of purple exploitation as one of the main activities and have made possible the documentation of more complex facilities associated with excavated structures and the extensive shell midden. Along with these, other buildings and shell middens have been found throughout the coast of this location. This study emphasised the first results of the 2019 and 2021 campaigns.
Attention-Enhanced Region Proposal Networks for Multi-Scale Landslide and Mudslide Detection from Optical Remote Sensing Images
Authors: Niu Chong , Ma Kebo , Shen Xiaoyong , Wang Xiaoming , Xie Xiao , Tan Lin , Xue Yong
Published: January 2023

Detecting areas where a landslide or a mudslide might occur is critical for emergency response, disaster recovery, and disaster cost estimation. Previous works have reported that a variety of convolutional neural networks (CNNs) significantly outperform traditional approaches for landslide/mudslide detection. These approaches always consider features from the local window and neighborhood information. The CNNs mainly focus on the features derived at a local scale, which might be inefficient for recognizing complex landslide and mudslide scenes. To effectively identify landslide and mudslide risks at a local and global scale, this paper integrates attentions into the architecture of state-of-the-art CNNs—including Faster RCNN—to develop an attention-enhanced region proposal network for multi-scale landslide/mudslide detection. In detail, we employed the attentions to process the region proposals generated by a region proposal network and then combined the results obtained from the attentions and region proposal network to identify whether the object included in a region proposal was a landslide/mudslide. Based on our developed dataset and the Bijie dataset, the experimental results prove that: (1) although the state-of-the-art CNNs for object detection can precisely detect landslides and mudslides, they are inadequate in dealing with similarity to non-landslide/non-mudslide regions; and (2) the proposed method, which integrates global features from attention layers into local features derived from CNNs, outperforms the unmodified CNNs in detecting non-landslides and non-mudslides. Our findings prove that the representations at the local and global scale might be significant for precise landslide and mudslide detection.
A Multicriteria Approach to Adaptive Reuse of Industrial Heritage: Case Studies of Riverside Power Plants
Authors: Añibarro María V. , Andrade María J. , Jiménez-Morales Eduardo
Published: January 2023

City riverbanks usually have great landscape value and are iconic public spaces. However, there are many cities with large abandoned industrial buildings, such as power plants, on their riverbanks. Such buildings run the risk of being demolished in order to recover the surrounding natural landscape, despite having an important presence in the collective memory of the citizens and in the history of the city. This article seeks to analyse the reuse and refurbishment of industrial power plants on riversides from a modern artistic/recreational approach in order to restore and enhance the landscape value of the site by regenerating the environs and turning them into hubs of activity. Two case studies from different locations are considered in order to extract the information. A methodology is used that allows us to analyse and study a complex reality in a straightforward, concise and direct way. That means it can be used by many agents currently involved in those reuse processes to compare and to monitor the different cases over time. This research has sought to highlight the power plant typology, its relationship with the riverside, and subsequently, to extrapolate the criteria used to study other industrial buildings.
The Use of UAVs for Land Use Planning of Brownfield Regeneration Projects-Case Study: Former Brick Factory, Cluj Napoca, Romania
Authors: Naș Sanda Marioara , Bondrea Mircea Vasile , Rădulescu Virgil Mihai , Gâlgău Raluca , Vereș Ioel Samuel , Bondrea Raluca , Rădulescu Adrian Traian
Published: January 2023

Brownfields are a real problem which affects the urban appearance of cities and the quality of life of their inhabitants. In Romania, industrial areas were mainly concentrated on the outskirts of large cities, in the immediate vicinity of residential areas. With the closing of factories and the additional population of the big cities, there was a need for expansion of residential areas with a social-economic function. This paper proposes a case study from the classical surveying measurement equipment (GNSS—Global Navigation Satellite System and TS—Total Station) for land use planning of brownfield regeneration projects. The chosen area is in the northwest part of Romania, in Cluj-Napoca, where a former brick factory was closed, leaving behind unaesthetic and unused land. In this paper, it is suggested that a better understanding of the way in which UAV—Unmanned Aerial Vehicle—aerial photogrammetry can contribute to providing information for the design and development of this area. In addition, this study confirms the advantages of effective and practical use of the obtained geospatial information for the design of a residential complex in the studied area, a complex proposed as a sustainable alternative to the former industrial area. Observation and analysis of the differences between the two topo-geodetic works were carried out with the help of UAV technology, such as GNSS—Global Navigation Satellite System and TS—Total Station technology, respectively, to create a topographic plan, level curves, and 3D models made of the building in the study area.
The Impact of the Deterioration on Wood by Chlorine: An Experimental Study
Authors: Costa Rúben D. F. S. , Barbosa Marta L. S. , Silva Francisco J. G. , Sousa Susana R. , Pinto Arnaldo G. , Sousa Vitor F. C. , Ferreira Bruno O.
Published: January 2023

The use of disinfection and cleaning chemicals in several municipal facilities, such as swimming pools and drinking water treatment plants, causes the degradation of various types of wood, which leads to failures in equipment and the corresponding need for maintenance. This degradation creates added costs for municipalities, as well as the closure of certain facilities due to curative or preventive maintenance and, in many cases, public health issues, due to the water being contaminated with deteriorating products. Through a thorough study of the degradation effect on the products, more resistant materials can be found which are able to withstand these adversities and increase the lifespan of wood in regular contact with chemical agents. This is achievable by the determination of the cost-effectiveness of the substitute material to replace these components with alternative ones, with properties that better resist the deterioration effects promoted by aggressive environments. No studies have been found so far strictly focused on this matter. The objective of this study is to evaluate the degradation presented by two types of wood, beech and oak, which are exposed to the action of chlorine in municipal facilities. This degradation varies according to the chlorine content and the materials’ time of contact with the chemical agent, allowing the selection of new materials which will provide an extended lifetime of the components, reducing maintenance drastically, as well as costs for the facilities and the risk to public health. The performed experimental tests have shown that the oak wood has the best results regarding chlorine degradation resistance.
Bitumen-Based Poroelastic Pavements: Successful Improvements and Remaining Issues
Authors: Jaskula Piotr , Ejsmont Jerzy A. , Gardziejczyk Wladyslaw , Mioduszewski Piotr , Stienss Marcin , Motylewicz Marek , Szydlowski Cezary , Gierasimiuk Pawel , Rys Dawid , Wasilewska Marta
Published: January 2023

This article presents the development process of designing and testing poroelastic pavement based on highly polymer-modified bitumen. Poroelastic wearing course was composed of mineral and rubber aggregate mixed with highly polymer-modified bitumen, in contrast to previous trials, during which polyurethane resins were mainly used as binder, which led to several serious technological problems concerning difficult production, insufficient bonding to the base layer, and unsatisfactory durability. The laboratory testing phase was aimed at finding the proper composition of the poroelastic mixture that would ensure required internal shear strength and proper bonding of the poroelastic layer with the base layer. After selecting several promising poroelastic mixture compositions, field test sections were constructed and tested in terms of noise reduction, rolling resistance and interlayer bonding. Despite the very good acoustic properties of the constructed poroelastic wearing course, it was not possible to solve the problem of its insufficient durability. Still, the second major issue of poroelastic pavements that concerns premature debonding of the poroelastic layer from the base layer was completely solved. Experience gained during the implementation of the described research will be the basis for further attempts to develop a successive poroelastic mixture in the future.
Load-Oriented Nonplanar Additive Manufacturing Method for Optimized Continuous Carbon Fiber Parts
Authors: Kipping Johann , Schüppstuhl Thorsten
Published: January 2023

The process of the additive manufacturing (AM) of carbon-fiber-reinforced polymer (CFRP) parts based on the process of fused deposition modeling (FDM) has seen considerable research in recent years, which amplifies the importance of adapted slicing and pathplanning methods. In particular, load-oriented techniques are of high interest when employing carbon fiber materials, as classical methods, such as tape-laying and laminating, struggle with highly curved and complex geometries and require the costly production of molds. While there have been some promising propositions in this field, most have restricted themselves to a planar slicing approach, which severely limits the ability to place the fibers along stress paths. In this paper, a nonplanar slicing approach is presented that utilizes principal stress directions to construct optimized nonplanar constituting layers on which pathplanning can be carried out. These layers are oriented such that the effect of the weak interlayer adhesion is minimized. Support material is adaptively generated to enable the use of arbitrary part geometry. Furthermore, a continuous pathplanning method and post-processor are applied to yield manufacturing instructions. The approach is verified for its viability of application through experimental investigation on a multi-axis robotic 3D printer. This constitutes an important step in allowing the fabrication of CFRP parts to further utilize the possibilities of additive manufacturing.
Microstructure and Salt Fog Corrosion of Wrought Mg-Al-Zn and Mg-RE Alloys
Authors: Kamoutsi Helen , Haidemenopoulos Gregory N. , Gunnaes Anette E. , Diplas Spyros
Published: January 2023

Wrought magnesium alloys have received attention due to their potential application as lightweight materials. However, their use is limited by their poor corrosion resistance. Rare earth additions have the potential to enhance corrosion resistance. The present work included a microstructural investigation and corrosion testing of the alloy WE-43, containing Nd and Y, which was compared against the more conventional compositions of AZ31 and AZ61 alloys. All three alloys exhibited a recrystallized equiaxed structure after hot rolling with the presence of second phases—precipitates. The WE-43 alloy exhibited a better corrosion resistance than AZ31 and AZ61 under salt fog testing, indicated by the lower depth of attack and lower weight loss. The second phases in the microstructure of AZ31 and AZ61 alloys determined their corrosion resistance. The second phases in the AZ31 and AZ61 alloys (based on Al-Mg and Al-Mn phases) were nobler than the Mg matrix and catholically acted, thus sacrificing the Mg matrix. The superior corrosion resistance of WE43 was due to the incorporation of Y in the oxide/hydroxide film. In addition, the second phases in the WE43 consisted of Nd and Y and were less noble than the Mg-matrix. Thus, they acted as anodic sites protecting the Mg-matrix. The above results show the beneficial effect of rare earth additions to wrought Mg alloys towards increased corrosion resistance.
Experimental Study of Robotic Polishing Process for Complex Violin Surface
Authors: Wahballa Hosham , Duan Jinjun , Wang Wenlong , Dai Zhendong
Published: January 2023

This paper presents a robotic polishing process for complex violin surfaces to increase efficiency and minimize the cost and consumed time caused by using labor and traditional polishing machines. The polishing process is implemented based on modeling a smooth path, controlled contact force embedded with gravity compensation and material removal depth. A cubic Non-Uniform Rational Bases-Spline (NURBS) interpolation curve combined with an S-curve trajectory model is used to generate a smooth polishing path on a complex violin surface to achieve stable motion during the polishing process. An online admittance controller added to the fast gravity compensation algorithm maintains an accurate polishing force for equal removal depth on all polished surface areas. Then, based on Pythagorean theory, the removal depth model is calculated for the violin’s complex surface before and after polishing to estimate the accuracy of the polishing process. Experimental studies were conducted by polishing a wooden surface using the 6DOF robot manipulator to validate this methodology. The experimental results demonstrated that the robot had accurate polishing force based on the online admittance controller with gravity compensation. It also showed a precise proportional uniformity of removal depths at the different normal forces of 10, 15, and 20 N. The final results indicated that the proposed experimental polishing approach is accurate and polishes complex surfaces effectively.