bluuebunny/crossref_metadata_2025 huggingface dataset:
Числа низшего порядка. Противоречие степени единицы. Математика как нестатичная наука
Authors: Полякова И.С
Published: August 2023

В статье показано, что степени единицы противоречивы. С одной стороны единица в любой степени дает саму себя, но с другой мы допускаем существование логарифмов по разным основаниям от разных чисел. В статье отмечено, что можно допустить обе возможности. Также отмечено, что при вычитании ноля из самого себя и при делении единицу на саму себя получаются числа низшего порядка 0 и 1. Числа низшего порядка можно расширить до множества, поставив в соответствие каждому вещественному числу число низшего порядка. Математика не является статичной наукой, ее законы претерпевают изменения, могут меняться со временем, разные законы применимы для разных множеств.
Юридическое лицо как субъект административного правонарушения, административное правонарушение юридического лица, сущность административной ответственности, проблемы определения административной ответственности
Authors: Боровкова А.В.
Published: August 2023

В этой статье разберем что такое:- административная ответственность юридического лица; - административное правонарушение юридического лица; - сущность административной ответственности юридического лица; - проблемы, возникающие для определения административной ответственности.
Защита прав и свобод несовершеннолетних в уголовном судопроизводстве
Authors: Камчиев Б.К , Абдурахманова А.С.
Published: August 2023

В статье проведен анализ нормативного регулирования судопроизводства с участием несовершеннолетних. Обозначены актуальные вопросы нормативного регулирования. Определены роль международно-правовых и национальные актов в области прав несовершеннолетних и их значимость в современных условиях правовой действительности
Процессуальные особенности соединения и выделения уголовных дел
Authors: Карабаева К.К , Нажимидин А
Published: August 2023

В статье проведен анализ соединения и выделения уголовных дел в уголовно процессуальном законодательстве. Обозначены законодательные и теоретические критерии соединения и выделения уголовных дел. Обобщены процессуальные характеристики соединения и выделения уголовных дел
Bank Selection when Installing Booms on Rivers
Authors: Khayrullin D.R. , Sultanmagomedov S.M. , Sultanmagomedov T.S.
Published: August 2023

The features of the installation of booms on rivers were given, taking into account the fact that rivers form periodic ancones, which causes an uneven distribution of river flow along the bed. The article proposes the most optimal way to install booms on rivers based on a series of experiments. Detailed calculations were presented to determine the elongation of booms when they are installed on rivers. Flow loads were determined and presented, as well as their distribution along the floating boom outline. Variants of installation of booms on ancones and straight sections of rivers were considered. The optimal bank for the installation of booms was identified, taking into account the conditions for ensuring the best holding capacity of booms, as well as the convenience of collecting oil and other factors.
Prospects for the Development of the Carbon Capture, Use and Storage Industry in Russia
Authors: Vanchugov I.M. , Zharkova V.V. , Sun Fachjan , Shestakov R.A.
Published: August 2023

The world experience of carbon capture, use and storage (CCUS) projects in the world was presented and analyzed – the entire CCUS technological chain was shown, including a description of its elements, and the areas of CO2 use in different areas of global industry are given. The prerequisites and prospects for the formation of CUS in Russia are presented. A qualitative and quantitative assessment of the underground space of the regions of Russia for the disposal of carbon dioxide is given. It is worth noting that the concentration of large enterprises of the metallurgical industry, oil refining, chemical industry and oil and gas fields allows you to create a special CCUS cluster and reduce emissions of pollutants, as well as effectively use the captured CO2 in various industries of Russia.
A Mathematical Model for Assessing the Impact of a Man-Made System on an Air Basin
Authors: Krupskaya L.T. , Kulikova E.Yu. , Filatova M.Yu. , Leonenko A.V.
Published: August 2023

The results of many years of research on the assessment of the impact on the air basin of the technogenic system – tailings dumps of highly toxic waste using methods of mathematical statistics is presented. The research was carried out within the boundaries of the Dalnegorsky Ore District of the Primorsky Territory of the Far Eastern Federal District (Far Eastern Federal District). It has been established that the main pollutant is dust containing elevated concentrations of heavy metal compounds, which is removed from the surface of tailings dumps by air flows. The spatial and temporal patterns of the distribution of the pollutants in the atmospheric air are revealed. It has been experimentally proved that contamination of the air basin with heavy metal compounds, sulfate ion aerosols, and dust is extremely high. The ways of reducing its negative impact on the air basin are proposed.
The Role of MicroRNAs in Development of Endometrial Cancer: A Literature Review
Authors: Indumati Somasundaram , Apurva Birajdar , Gaurav Gaur , Nehakumari Singh , Nishant Vyas
Published: July 2023

Endometrial cancer (EC) ranks as the second most common gynaecological cancer worldwide. EC patients are diagnosed at an early clinical stage and generally have a good prognosis. Therefore, there is a dire need for development of a specific marker for early detection of endometrial adenocarcinoma. The development of EC is conditioned by a multistep process of oncogenic upregulation and tumor suppressor downregulation as shown by molecular genetic evidence. In this setting, microRNAs appear as significant regulators of gene expression and several variations in the ex-pression of microRNAs have been implicated in normal endometrium, endometrial tissue, metrorrhagia, and endometrial cancer. Furthermore, microRNAs act as highly precise, sensitive, and robust molecules, making them potential markers for diagnosing specific cancers and their progression. With the rising incidence of EC, its management remains a vexing challenge and diagnostic methods for the disease are limited to invasive, expensive, and inaccurate tools. Therefore, the prospect of exploiting the utility of microRNAs as potential candidates for diagnosis and therapeutic use in EC seems promising.
The Child's Right to Know Versus the Parents’ Right Not to Tell: The Attitudes of Couples Undergoing Fertility Treatments Towards Identity-Release Gamete Donation
Authors: Oliveira Rocha Douglas , Massaro Melamed Rose Marie , De Almeida Ferreira Braga Daniela Paes , Souza Setti Amanada , Iaconelli Jr Assumpto , Borges Jr Edson
Published: July 2023

Background: In Brazil, donor anonymity is mandatory; however, the tendency of Brazilians towards the practice is unknown. In this study, an attempt was made to investigate whether couples undergoing assisted reproductive technology (ART) have a different perception of anonymous versus identity-release gamete donation than a target population in Brazil.
Methods: This cross-sectional study was performed from September 1, 2020 to December 15, 2020. For that purpose, surveys through online platforms were con-ducted, including either patients undergoing ART (ART-group, n=400) or subjects interested in the theme (interested-group, n=100) randomized by age at a 1:4 ratio. The survey collected information on the participants’ attitudes towards anonymity of gamete donors, and answers were compared between the groups.
Results: Most participants stated that the relationship between children and their parents would be affected by the child's knowledge of the origin of its conception. Most participants in the ART-group believed that the gamete donor’s identity should not be revealed to the child, while only half of the interested-group stated the same. Most of the participants stated that "the donor's identity should be revealed if the child questions its biological origin". "From birth" was the second most common response, while "when the child turns 18 years old" and "sometime during teenage years" were less common answers.
Conclusion: The attitudes of ART patients about anonymity are conservative, with most participants believing that family relationships may be affected if the child is aware of the origin of his/her conception. These patients also believe that the identity of the gamete donor should not be revealed to the child.
Fumarase Deficiency and Its Effect on Infertility: A Case Series
Authors: Wesley Schwartz Jessica , Peyser Alexandra , Tarrash Miriam , Heather Goldman Randi
Published: July 2023

Background: Fumarase deficiency is an autosomal recessive condition characterized by severe neurologic abnormalities due to homozygous mutations in the fumarate hydratase (FH) gene. Heterozygous carriers of FH mutations have increased risk of developing uterine fibroids that can be associated with hereditary leiomyomatosis and renal cell cancer (HLRCC). The association between FH mutations and infertility remains uncertain. The objective of our study was to characterize the infertility diagnoses, treatments, and outcomes in women presenting to a fertility center who were found to be carriers of fumarase deficiency based on the presence of heterozygous FH mutations.
Case Presentation: A retrospective case series was conducted including 10 women presenting to an academic fertility center who were found to be FH carriers based on genetic carrier screening. Of the 9 women who were engaged in further workup, 2 had imaging results consistent with uterine fibroids. One woman underwent hysteroscopic myomectomy prior to two courses of ovulation induction with timed intercourse (OI/TIC) followed by one successful cycle of IVF. Of the remaining patients, only 1 woman successfully delivered after a cycle of ovulation induction with intrauterine insemination (OI/IUI). Other patients pursuing OI/IUI, OI/TIC, or monitored natural cycles had unsuccessful experiences.
Conclusion: Patients with infertility who are offered genetic testing should be screened for FH mutations, as the carriers are at risk of developing HLRCC-associ-ated uterine fibroids, which can influence fertility and pregnancy. Additional research is needed to investigate the impacts of FH mutations on infertility.
Treatment of Immature Teratoma Associated with Ovarian Endometrioma: A Case Report
Authors: Amini Moghaddam Soheila , Sarchami Niloufar , Rahbari Ali
Published: July 2023

Background: Mature teratoma is a benign neoplasm, mostly composed of well-differentiated derivations of almost two or three germ cell layers, while immature teratoma is a malignant neoplasm composed of immature neural and embryonic tissue. Immature teratoma in the context of ovarian endometrioma has not been reported yet.
Case Presentation: A 34-year-old woman with primary infertility is reported in this study who suffered from immature teratoma associated with ovarian endometrioma. After several rounds of fertility treatment, the patient was referred for severe abdominal pain and underwent emergency surgery for the rupture of ovarian endometrioma. To preserve the ovary, the cyst was not resected in areas attached to the ovary. Some months later, the patient noticed a progressive abdominal enlargement. The sonographic evaluation revealed multiple solid-cystic lobulated masses on the abdominal wall and throughout the pelvic cavity. The histologic diagnosis was consistent with immature teratoma. The patient was treated with high-dose neoadjuvant chemotherapy and fertility-sparing surgery (FSS). The histologic evaluation of the extracted masses revealed teratoma maturation.
Conclusion: This study reveals the importance of complete removal of endometrioma and highlights the role of neoadjuvant chemotherapy in fertility-sparing surgery and potentiating teratoma maturation.
Design, Synthesis and Anti-Bacterial Activity Evaluation of Indole-Based Benzophenone and Their Derivatives
Authors: ERABE Fekadu Tumoro , KURE Dagne Adisu , SHERİF Salah
Published: July 2023

Indole and benzophenone moiety are of significant interest to investigators because they are found in many natural products and pharmacologically active compounds. They represent versatile synthetic building blocks. The benzophenone and indole scaffolds are special structures in medicinal chemistry because these compounds are found in several biologically active natural products, compounds containing indole and benzophenone exhibit anticancer, antiinflammatory, antimicrobial, and antiviral activities. In this study, derivatives of 2-(diphenyl methylene) hydrazine, containing both indole and benzophenone moieties were successfully synthesized. The structural elucidation of the synthesized compounds were done using spectroscopic techniques like IR, 1HNMR, and 13CNMR. The synthesized target compounds were investigated for their in vitro antibacterial activity against two bacterial strains; staphylococcus aureus (S. auras), and Escherichia coli (E. coli) using the disc diffusion method. All synthesized target compounds showed no significant activity against Staphylococcus aureus (S. aureus) but exhibited moderate activity against Escherichia coli (E. coli). Among all the synthesized compounds, 2-(diphenyl methylene)-1-((1-tosyl-1H-indol-3-yl) methylene) hydrazine (BHT) (7b) showed a good inhibition at a concentration of 50 μg/mL with a zone of inhibition of 21.7 mm against Escherichia coli (E.coli) which was comparable with standard drug Ceftriaxone with the zone of inhibition of 26 mm. Thus, this compound could be considered as a lead molecule to design and develop novel antibacterial drugs.
Cultura, artesanía y diseño
Authors: Marmolejo  Cueva Melba Cristina , Maldonado Mangui Silvia Paulina , Isin Vilema Manuel David
Published: August 2023

El revalorar los saberes tradicionales y cuestionar el proceso científico implica validar metodologías que originan la exploración de nuevos senderos investigativos.
La creación de sistemas tipográficos. Una reflexión desde la epistemología del diseño
Authors: Sandoval Sarmiento Laura Judith
Published: August 2023

La interacción de grupos humanos y sus prácticas intersubjetivas responden tanto a intereses como objetivos consensuados o en disputa.
Fake News y desinformación: desafíos para las democracias de América Latina y el Caribe
Authors: Mendoza Marina , Dagatti Mariano , López López Paulo Carlos
Published: August 2023

El Proyecto de Investigación 19.3 investiga y reflexiona, sobre el impacto que las noticias falsas generan en las democracias latinoamericanas.
La muerte del otro: La periferia de lo animal
Authors: Páez Vanegas Camilo
Published: August 2023

La tendencia cada vez mayor en las ciudades de incorporar animales a los núcleos familiares replantea la percepción del animal como un “otro” que no se puede abordar a pesar de la autoridad que se ejerce sobre ellos al pretender su humanización, propia del pensamiento occidental para explicar los fenómenos del mundo natural.
Árboles dispersos en fincas del oriente cundinamarqués y su aporte a la conectividad del paisaje
Authors: Díaz Santamaría William Ricardo , García Vargas Raúl Gonzalo , Forero Vargas Camilo
Published: August 2023

El diseño, implementación y manejo de sistemas agropecuarios productivos que contemplen la incorporación del componente arbóreo como un eje estratégico para salvaguardar la diversidad ecosistémica en las regiones, es vital cuando se quiere preservar la biodiversidad local y recuperar la conectividad ecológica de fragmentos boscosos en las cuencas hidrográficas. La heterogeneidad del paisaje, la diversidad de cultivos en los sistemas productivos agrícolas y el análisis de los árboles dispersos en predios rurales productivos, son parte de los aspectos constitutivos para el estudio de la conectividad a escala local y regional logrando determinar, los cambios en las coberturas vegetales, la provisión de material genético e incluso, establecer puntos locales para acciones de restauración de ecosistemas. Esta investigación estudió las coberturas del suelo de 32 fincas ubicadas en los municipios de Chipaque, Cáqueza, Quetame y Guayabetal, en el oriente de Cundinamarca y analizó los indicadores de conectividad generados por los árboles remanentes con el fin de establecer indicadores que permitan en el futuro optimizar los procesos de reforestación. Se seleccionaron 8 predios por cada uno de los municipios. La información fue recolectada directamente en campo a partir de mediciones de áreas, coberturas e inventarios florísticos predio a predio. Para facilitar el análisis de la información se utilizó el software fragstats versión 4,2,1. El estudio muestra que en algunos casos las coberturas más abundantes corresponden a pastos, pero que en otros casos existen parches importantes de bosque que pueden ser tenidos en cuenta para orientar más eficientemente los procesos de reforestación a futuro.
Electrical Conductivity and Association of 1-butyl-3-methylpyridinium bis{(trifluoromethyl)sulfonyl}amide in Some Polar Solvents
Authors: Karpunichkina I.A. , Artemkina Yu.M. , Plechkova N.V. , Shcherbakov V.V.
Published: July 2023

The influence of alternating current frequency in the determination of the electrical conductivity of ionic liquids’ (ILs) dilute solutions in polar solvents has been considered. The frequency ranges in which the influence of polarization processes on electrodes occur and ionic relaxation occurs in the bulk of the solution have been excluded from the results of the electrical conductivity measurements. The association constants for Ka ILs in polar solvents published in literature were analyzed. A discrepancy between the values of Ka was noted, which is associated with the use of different calculation equations for electrical conductivity and the insufficiently correct consideration of the frequency dependance of the measured resistance. Based on the measured values of the electrical conductivity of dilute solutions of 1-butyl-3-methylpyridinium bis{(trifluoromethyl)sulfonyl}amide ([Bmpy][NTf2]) in acetonitrile (AN), dimethyl sulfoxide (DMSO) and dimethylformamide (DMF) in the 20--65 °C temperature range, the thermodynamic characteristics of the [Bmpy][NTf2] association were determined. The effect of temperature on the molar electrical conductivity of [Bmpy][NTf2] at infinite dilution λ0 and the association constant Ka have been considered. The Walden product (λ0η), where η is the viscosity of the solvent, was also analysed. It was shown that in AN, DMSO, and DMF, λ0η changes in different ways with increasing temperature; however, the value of λ0η/(εT) corrected for permittivity ε and absolute temperature T does not depend on the temperature and nature of the solvent. As the temperature rises, the electrical conductivity of the dilute solutions of [Bmpy][NTf2] increases in direct proportion to the ratio of the permittivity to dipole dielectric relaxation time of the solvent
Introduction of the Allan Variance Method in Studying the Physical and Chemical Processes on the Solid Body Surface
Authors: Lunin B.S. , Basarab M.A. , Konnova N.S. , Stroganov I.S.
Published: July 2023

The Allan variation method is being effectively used to study stability of frequency generators and noise characteristics of the dynamic processes of various physical nature presented in the form of time series. At the same time, the methods of nonlinear dynamics, in particular, of the fractal analysis, are used both in processing the time series and in studying irregularities in profiles or surfaces. By analogy with this, the possibility of introducing the Allan variance method to analyze alterations in the solid body surface during chemical and thermal treatment was evaluated. Introduction of the Allan variance method makes it possible to quantify the roughness components corresponding to the surface defects of a certain size. Alterations in the surface of grounded and polished quartz glass plates were studied, as well as the melted rods during chemical dissolution of the surface layer. The presented graphs and calculated Allan variations for the profiles of various surfaces clearly demonstrate that alterations in the surface relief standard deviation during chemical etching of the quartz plates and bars is associated with the surface defects size. The results of studying the surface stay in good agreement with the estimates made by the fractal analysis method. Introduction of the Allan variance method makes it possible to optimize both the mechanical and the chemical surface treatment mode of various parts during their manufacture
Real Power Loss Reduction by Maine Coon and Perognathinae Based Optimization Algorithm
Authors: Kanagasabai L.
Published: July 2023

This paper proposes Maine Coon and Perognathinae based optimization (MPO) algorithm for solving the power loss lessening problem. Usual behaviour between Maine Coon and Perognathinae is imitated to formulate the MPO algorithm. In the proposed MPO, the crusade of Maine Coon towards Perognathinae as well as the spurt of Perognathinae in the direction of anchorages is replicated. Proposed MPO is population-based procedure which is premeditated by imitating the natural actions of a Maine Coon assaults on Perognathinae and absconding of Perognathinae to the anchorage. The exploration agents in the projected MPO algorithm are alienated into two clusters of Maine Coon’s and Perognathinae that examine the problem exploration space with arbitrary activities. The projected MPO algorithm apprises population associates in two segments. In the principal segment, the crusade of Maine Coon’s in the direction of Perognathinae is modelled, and in the subsequent segment, the absconding behaviour of Perognathinae to anchorages to protect its life is designed. From a scientific fact of opinion, every associate of the populace is a recommended solution to the problem. In detail, an associate of the population postulates standards for the problem parameters rendering to its location in the exploration space. Proposed MPO algorithm is appraised in IEEE 30 bus system and IEEE 14, 30, 57, 118, 300 bus test systems without considering the voltage constancy index. True power loss lessening, voltage divergence curtailing, and voltage constancy index augmentation has been attained
Features of Propagation of the SV-Polarized Normal Waves in the Composite Materials Made of Carbon Fiber
Authors: Aleshin N.P. , Deryabin A.A. , Shchipakov N.A. , Kozlov D.M.
Published: July 2023

Based on analyzing results of the existing works, the paper demonstrates that the method of simulating motion of the SV-polarized normal waves using the classical theory of deformation appears promising in simulating their propagation in the layered polymer composite materials, as well as in studying the effect of discontinuities in such materials on the considered waves’ parameters. A model was created to analyze specifics of the described waves’ propagation in the polymer composite materials based on the carbon fiber. Formulas were obtained to calculate the amplitude coefficients for the motion equations to take into account acoustic characteristics of the polymer composite material layers and make it possible to calculate the displacement components or the energy distribution at any point in the layered medium. Phase velocity values were determined, and dispersion curves were constructed for various modes of the SV-polarized normal waves. Influence of the material layered structure on attenuation of those waves was considered, and the principle of correcting the formulas for calculating the attenuation coefficients taking into account the number of layers and their acoustic properties was outlined. Phase velocity values of the SV-polarized normal waves was experimentally verified on the sample of polymer composite materials confirming correctness of the simulation approaches
USO DE METODOLOGIAS ATIVAS NO ENSINO DE LÍNGUA PORTUGUESA PARA O ENSINO MÉDIO
Authors: Lisboa Lucília Glória Serra , Severiano Junior Ely
Published: July 2023

O presente estudo tem como objetivo geral mostrar o processo de utilização das metodologias ativas pelos docentes de Letras como método de ensino e aprendizagem para Língua Portuguesa. A justificativa para a temática se dá em razão da inserção das tecnologias no sistema educacional e da contribuição para o ensino. Desse modo, o propósito das metodologias ativas é dar suporte e criar oportunidades de compartilhar diversas formas de aprendizagem, como, o uso da sala de aula invertida, de modo a possibilitar variados métodos para aquisição de conteúdos, por exemplo, inserção de videoaulas, games, livros e textos didáticos. A metodologia da pesquisa é de caráter qualitativo, com professores de Língua Portuguesa do Ensino Médio. Os dados mostram que a inserção de um recurso midiático contribui significativamente para a aprendizagem do discente, haja vista a capacitação do docente com as tecnologias digitais de informação e comunicação, sendo um meio que orienta para a aplicação no processo de ensino e aprendizagem. À luz dessas considerações, são propostas novas pesquisas como forma de ampla visão e de quebra de paradigma, buscando, assim, novos métodos para o ensino de Língua Portuguesa. Portanto, conclui-se que o uso das metodologias ativas faz parte do processo de capacitação e aperfeiçoamento dos docentes, assim como dá autonomia e criticidade ao aluno. Para tanto, o uso das metodologias tornou-se recorrente dentro e fora da sala de aula como método de aprendizagem. Deste modo, as metodologias ativas promovem aprendizagem significativa, ou seja, proporcionam novos significados, novas formas de aprendizagem e amplitude para o conhecimento.
AMBIENTES NO METAVERSO PARA FORMAÇÃO DOCENTE EM ARTES VISUAIS E TEATRO
Authors: Oliveira Régis Costa de , Silva Marineide Câmara
Published: July 2023

O presente artigo descreve o processo de criação e customização de ambientes na plataforma de metaverso Spatial, desenvolvidos para os componentes curriculares Arte e Tecnologia, da Licenciatura em Artes Visuais do Instituto Federal de Educação, Ciência e Tecnologia do Maranhão (IFMA), Campus São Luís - Centro Histórico e História do Teatro III, da Licenciatura em Teatro da Universidade Federal do Maranhão (UFMA), Campus São Luís.  A partir de referências teóricas de Roesller (2012), Ball (2021), Parreira, Lehman e Oliveira (2021), Backes e Schlemmer (2014) e Wakefield (2022), o artigo analisa as contribuições que as plataformas de metaverso podem trazer para a formação docente, com ênfase para os recursos presentes na plataforma Spatial, e a relação destes com as especificidades das licenciaturas em Artes Visuais e Teatro. Com base em experiências práticas, o artigo explora a criação de uma galeria virtual para a exposição coletiva Art and Tech, e sua utilização para as práticas da organização do espaço expositivo e da mediação cultural, bem como a construção de um arquivo virtual destinado ao registro das transformações do teatro Arthur Azevedo. As etapas percorridas durante a criação desses ambientes virtuais imersivos são analisadas, com destaque para as possibilidades de customização e adaptação pedagógica dos recursos tecnológicos oferecidos pela plataforma Spatial. Ao final, o artigo aponta para a importância de uma abordagem crítica em relação ao uso das tecnologias digitais na formação docente, bem como para a necessidade de um constante diálogo entre teoria e prática.
Minimalismo modular generativo
Authors: Cañete Islas Omar , Bravo Jose
Published: July 2023

A partir de las propiedades transformacionales y generativas de la forma, planteadas desde la matemática y geometrías como los fractales (Mandelbrot, 1984) y los sistemas iterados (Lindenmeyer y Presemslaw, 2000) plantean posibilidades de trabajo y modelación digital, basado en las denominadas morfologías de lo amorfo (Cañete, 2016, 2017a; 2018), buscando asimilarla a los principios propios de la arquitectura y estética moderna y contemporánea, como el trazo libre, minimalista y esencial, atendiendo en especial, a la riqueza de su patrones y configuraciones, como a sus propiedades escalares y transformacionales. Es así como, en publicaciones anteriores, se ha trabajado, desde la docencia universitaria y diversos proyectos de artes visuales, el trabajo y desarrollo de modelos de fragmentación y crecimiento escalar, que deriven en la generación de módulos, tramas, landscape, etc, entendiendo minimalismo y complejidad, como pares que se conjugan en el proceso generativo (generatrices morfológicas) mostrando diversas posibilidades de asimilación creativa desde la arquitectura.
Features of differential diagnosis of odontogenic cystsin children
Authors: Fomenko Irina V. , Sidoruk Victoria A. , Kasatkina Anzhella L. , Sidoruk Anatoly V. , Timakov Ilya E.
Published: July 2023

Relevance: Odontogenic jaw cysts of inflammatory genesis in children are a cavity formation in the bone tissue with a predominantly asymptomatic course. This clinical and radiological picture may be characteristic of a number of different pathologies, which poses the clinician with the task of conducting a thorough differential diagnosis. The purpose of the study: To perform a retrospective analysis of histological examination protocols of surgical material of patients operated on for jaw cysts. Materials and methods: The analysis of protocols of pathohistological examination of surgical material of patients operated on for jaw cysts for the period 20182022 in the childrens dental polyclinic No. 2 of Volgograd was performed. The data obtained were processed by methods of variational statistics. Results: 89 histological examination protocols were studied, the majority were radicular cysts associated with temporary teeth-58 (70.7 %), followed by follicular cysts-16 (19.5 %), then radicular cysts associated with permanent teeth - 7 (8.5 %), and in 1 (1.2 %) case a residual cyst was diagnosed. In 6 (6.7 %) cases, there was a discrepancy between clinical and pathohistological diagnoses. Conclusion: A pathohistological examination of the cyst shell is mandatory to establish a final diagnosis, however, for the differential diagnosis of a radicular cyst from a temporary tooth and a follicular cyst, a correlation of clinical, radiological and pathohistological signs is necessary.
Morphogenesis of thyropathies according to expression Oct3/4, PHH3, CK8, CK18 in chronic endogenous intoxication
Authors: Polyakova Lyudmila V. , Kalashnikova Svetlana A. , Vogel Andrey V.
Published: July 2023

Regeneration of internal organs under conditions of negative environmental impact, as well as adaptation to changing conditions of internal homeostasis in conditions of illness, is an urgent problem in regenerative medicine. The key links in the regulation of homeostasis are neuro-immune-endocrine relationships, where the main role in the regulation of metabolism is assigned to the thyroid gland. Morphological changes in the thyroid parenchyma under conditions of altered homeostasis in chronic endogenous intoxication (CEI) can lead to the formation of undiagnosed thyroid disorders and are not taken into the development of thanatogenesis. We conducted an IHC study to determine the main patterns of development of regenerative and adaptive processes of thyrocytes in conditions of CEI based on the expression of thyrocyte proliferation factors (PHH3), stem cells (Oct3/4), as well as to determine the risk of developing malignant neoplasms (CK8, CK18). It was found that in the formation of nodular neoplasms with a pronounced expression of PHH3 with a mitotic index of more than 25 %, it is necessary to conduct an IHC study to determine the expression of CK8, CK18 to identify the risk of developing thyroid neoplasms.
Comparative morphological characteristics of the proliferative activity and DNA content in the nuclei of cells of different lung cancer phenotypes
Authors: Ermilov Viktor V. , Bukatin Mikhail V. , Zatyamina Maria S. , Barkanova Olga N. , Barkanov Vyacheslav B. , Kolobrodova Natalia A. , Kuznetsova Olga Yu. , Shcherbakova Tatyana N. , Sokolova Anastasia V.
Published: July 2023

The choice of lung cancer treatment method directly depends on the diagnostisc and verification of the histological type of tumor. Important diagnostic criteria are DNA accumulation index and proliferation index of Ki-67. Materials and methods. DNA accumulation index was assessed in 200 cases of lung cancer using a microspectrophotometric method. Ki-67 proliferative index was calculated using immunohistochemical study in histological material with antibodies to Ki-67, Cytokeratin 5/6, TTF-1, Chromogranin A, Synaptophysin, Keratin.Pan, CD56. Results. As the degree of tumor differentiation decreases, DNA accumulation index and Ki-67 proliferative index increase, serving as criteria for the aggressive behavior of the tumor. Conclusions. Correlation analysis revealed a statistically significant relationship between DNA accumulation index and Ki-67 proliferative index (r = 0.987, p 0.05). The obtained data may be useful for diagnosis and prognosis in patients with lung cancer.
Somatic systemic complications of pancreatic necrosis: a review of the literature
Authors: Lopushkov Andrey V. , Burchuladze Nato Sh. , Popov Alexander S. , Mikhin Viktor S. , Kitaeva Anastasia V. , Kikteva Olga S. , Turovets Mikhail I. , Mikhin Igor V.
Published: July 2023

The analysis of publications devoted to the pathogenesis and prediction of the most frequent complications of patients with pancreatic necrosis was carried out. It was revealed that the issues of development and prevention of the described complications require further study, which will help in creating a personalized model for predicting complications necessary to justify preventive measures and reduce the mortality rate in patients of this category.
Fibrosis as a key link in the morphogenesis of extragenital endometriosis
Authors: Pechenikova Victoria A. , Korchinskaya Anastasia D. , Petrovskaya Nicole N.
Published: July 2023

The clinical of extragenital endometriosis is variable and depends on the localization, while the leading manifestation is a pronounced pain syndrome, which in some cases can simulate various surgical pathologies. Materials and methods: A morphological and IHC study was performed in 82 cases of extragenital endometriosis of various localization. Research results: An IHC study showed positive expression of -SMA in fibrosis foci around and between endometriosis foci. The expression area of TGF-1 was different for the cytogenic stroma and the perifocally located connective tissue. Conclusions: Fibrosis is an integral component of the morphogenesis of endometrioid heterotopias, while the degree of its severity depends on the duration of the existence of endometriosis foci. Severe pain syndrome is probably associated with deformation of organs and tissues, compression of nerve endings due to fibrosis processes.
Clinical features of recurrent vulvovaginitis in prepubertal age girls with extragenital diseases
Authors: Shchitenko Yulia I. , Zhukova Natalia P.
Published: July 2023

The purpose of the study is to investigate the clinical features of recurrent vulvovaginitis in prepubertal age girls with extragenital diseases. We examined 110 girls with recurrent vulvovaginitis, which were registered with the dispensary of pediatric gynecologist. We divided them into three groups depending on extragenital pathology: I group 38 patients with chronic urinary tract diseases; II 36 girls with allergic diseases; III 36 girls with gastrointestinal pathology, enterobiasis. Girls with chronic diseases of the urinary system complain of the pain and discomfort during urination, malaise in the genital area, discharge from the genital tract. Girls with allergic pathology complain of itching and burning in the genital area, restless behavior, dysuric phenomena. Girls with diseases of the gastrointestinal tract and enterobiasis complain of discomfort in the genital region, discharge from the genital tract because of constipation and bloating. The results of examination of the external genitalia, vulvoscopy also differed in girls. They depended on the acuty of the inflammatory process and predisposing factor. The clinical features of recurrent vulvovaginitis in prepubertal age girls with extragenital pathology were determined by the data of objective and instrumental examination of vulva.
Prospects for pharmacotherapy of diabetes mellitus using modern approaches to the correction of the gut microbiota
Authors: Nurgaleeva Elena A. , Linetskaya Olga I. , Levina Yana V. , Nurullina Tatiana N. , Rogova Natalia V.
Published: July 2023

The article proposes new strategies for the treatment of obesity-associated diabetes mellitus. The aim of the work was to study the effect of a high-carbohydrate type of nutrition on the qualitative and quantitative composition of the gut microbiota and feces of rats and the possibility of correcting the microbiome with the probiotic drug "Normobakt". Based on the results the gut microflora is proposed as a potential effective therapeutic target for improving the results of the treatment of diabetes mellitus and obesity.
Protective effect of a combination of the peptide mimicking the spatial structure of the B erythropoietin chain and infliximab on the epithelium of the nephron tubules in renal ischemia-reperfusion injury
Authors: Netrebenko Alexander S. , Gureev Vladimir V. , Pokrovsky Mikhail V. , Yakushev Vladimir I. , Saprykina Elena G. , Zatolokina Maria A.
Published: July 2023

Purpose: Due to the severe clinical course and the high socio-economic significance of acute kidney injury, the issue of methods for diagnosing and treating this pathology is on the agenda of the scientific community around the world. One of the most specific biomarkers of acute kidney injury is KIM-1. KIM-1 is an apical transmembrane protein of the proximal renal tubule. Elevated levels of KIM-1 in a model of ischemia-reperfusion injury of the kidneys correlate with inflammation and fibrosis in histological studies. The aim of this work was to study the protective effects of a combination of a peptide mimicking the -helix B of erythropoietin (pHBSP) and infliximab on the epithelium of nephron tubules in ischemia-reperfusion injury of the kidneys. Methods: The experiment was conducted on 80 white laboratory male Wistar rats weighing 280320 g. Animals were injected with a peptide mimicking the -helix B of erythropoietin (pHBSP) and infliximab. Under anesthesia, atraumatic vascular clamps were applied to the left renal pedicle for 40 minutes, nephrectomy on the right. Within 12 hours after reperfusion, urine samples were collected for laboratory studies. Results: According to the results of the experiment, it was found that the use of a combination of a peptide mimicking the -helix B of erythropoietin (pHBSP) and infliximab more effectively protected the epithelium of the nephron tubules from damage during ischemia-reperfusion injury of the kidneys than the administration of a peptide mimicking the -helix B of erythropoietin or infliximab in mono mode. Conclusion: The results of the study clearly substantiate the prospects for the combined use of a peptide mimicking the -helix B of erythropoietin (pHBSP) and infliximab to protect the nephron tubule epithelium from ischemia-reperfusion injury.
Giardiasis as a cause of acute urticaria (case study)
Authors: Sagitova Gulnara R. , Antonova Alyona A. , Davydova Oksana V. , Ledyaev Mikhail Y. , Komar Anastasia M.
Published: July 2023

The article describes a clinical case of acute urticaria against the background of a parasitic infection in a child who was examined and treated in the pediatric department of the State Budgetary Institution of Healthcare of JSC "Childrens Hospital No. 1". The description of this clinical case shows the ambiguity of the search for verification of the diagnosis.
Coronavirus infection (COVID-19): clinical case of a severe disease in a newborn
Authors: Karpukhina Oksana A. , Kramar Lyubov V. , Arova Anna A. , Larina Tatiana Yu.
Published: July 2023

The article presents a single clinical case of a severe coronavirus infection (COVID-19) in a newborn. Clinical and laboratory examination and treatment of the patient were carried out in accordance with the guidelines for the treatment of coronavirus infection in children. On the third day of hospitalization neonatal death occurred due to the development of multiple organ failure despite the medical therapy. An autopsy revealed diffuse alveolar damage (DAD) of the type of adult respiratory distress syndrome (ARDS) accompanied by bilateral polysegmental pneumonia and systemic inflammatory response syndrome.
Pharmacological animal models of schizophrenia for antipsychotic drug discovery and development
Authors: Kalitin Konstantin Yu. , Spasov Alexander A. , Mukha Olga Yu. , Pridvorov Gleb V.
Published: July 2023

Schizophrenia is a chronic psychoneurological condition that encompasses a wide variety of neurochemical, morphological, bioelectrical and behavioural changes. Comprehension of the mechanisms underlying schizophrenia and psychosis cannot be fully acquired in clinical studies with humans. For this reason, a number of experimental animal models of schizophrenia have been developed. Although none of the existing models of schizophrenia fully reproduces the complete spectrum of schizophrenia, critical aspects of pathology processes can be experimentally recapitulated. In this review we summarise the pathological features, advantages and limitations of the major pharmacological animal models of schizophrenia, including maternal immune activation. Commonly used pharmacological models of schizophrenia are useful for the preclinical evaluation of antipsychotic drugs and involve the dysfunction of various neurotransmitter systems, including dopamine, glutamate, serotonin. The review also describes maternal immune activation and neurodevelopmental rat models of schizophrenia. Positive, negative, and cognitive symptoms vary in degree and combination depending on the type of model used. A greater understanding of the strengths and weaknesses of various animal models of schizophrenia and the use of more than one model to evaluate antipsychotic activity would help to improve the efficiency of the drug discovery process and therapy translation from preclinical studies to patients.
Heart rate variability is a marker of the risk of maladaptation of students of various educational institutions
Authors: Yamanova Galina A. , Kudrin Rodion A. , Orlov Dmitry V.
Published: July 2023

A comparative analysis of the level of adaptive capabilities of cadet corps and secondary school students based on the study of heart rate variability. Materials and methods: Cadets (n = 64) and schoolchildren (n = 86) aged 1012 years took part in the study; spectral parameters of the heart rate were evaluated at rest and under conditions of an active orthostatic test. Results: It was found that the severity of the HF component of the heart rate decreases with age in cadets, which indicates a decrease in the effects of the parasympathetic system, (40.2 8.7) % at 10 years and (25.1 3.6) % at 12 years; р = 0.024. At the age of 12, the values of LF (р = 0.034), LF/HF (р = 0.031) and SI (р = 0.041) in cadets are higher than in schoolchildren, and HF (р = 0.022) are lower. During the active orthostatic test, the cadets showed a decrease in K30:15, as well as an increase in LF (р = 0.035), LF/HF (р = 0.041) and TI (р = 0.038), which demonstrates the predominance of the central contour of regulation. Conclusions: 1) spectral analysis of the heart rate indicates a marked increase in the stress of adaptive mechanisms with age in the cadets of the Cossack corps, which reflects increased physical, intellectual and psycho-emotional stress compared with schoolchildren; 2) spectral characteristics of heart rate variability can be used as sensitive markers of stress of physiological systems and a decrease in adaptive reserves.
Mutual influence of posters and kinematics of the temporomandibular joint
Authors: Parkhomenko Alexey N. , Shemonaev Victor I. , Barulin Aleksandr E. , Osokin Aleksandr V. , Maloletkova Anna A. , Kalinichenko Bogdan M.
Published: July 2023

Achievements in integrative areas of medicine can significantly supplement the traditional ideas about the etiopathogenesis of temporomandibular joint dysfunction, based on the positions of occlusal and neuromuscular theories and mainly limited to consideration of the elements of the stomatognathic system. The article presents the results of a study of data on the influence of the state of the spine on the pathogenesis of diseases of the temporomandibular joint and data on the effectiveness of the treatment of combined pathology of the joint and posture according to publications in domestic and foreign literature over the past 15 years. Expanding the view on the structure and function of the maxillofacial region and the role of craniopostural and craniovisceral relationships requires the development of a unified methodological approach to the diagnosis of patients with dysfunction of the temporomandibular joint, which will help reduce the number of diagnostic errors and the risk of chronic pain phenomena.
Retrospective analysis of the prevalence of diseases of the oral mucosa in the Volgograd region
Authors: Shkarin Vladimir V. , Poroysky Sergey V. , Makedonova Yulia A. , Dyachenko Svetlana V.
Published: July 2023

The paper presents the results of a retrospective analysis of the prevalence of diseases of the oral mucosa. It is noted that the high prevalence of various ORS diseases is associated with a new coronavirus infection COVID-19 due to immunopathological changes in the patients body. It is known that patients with OOP diseases represent one of the most difficult groups of patients in dentistry. An increase in the frequency of occurrence of erosive-ulcerative lesions of the ROR was noted, which have different etiology and pathogenesis, while their clinical picture is quite similar. The study was carried out in the dental clinics of Volgograd clinical bases of the Department of Dentistry of the Institute of the NMFO FSBEI HE VolgGMU of the Ministry of Health of Russia. 2719 medical records of a dental patient (form 043y) were studied in the period 20192022. There was a significant dynamic growth, especially in 2022, of inflammatory-destructive pathologies of the COR, as well as the highest prevalence of COR pathologies in middle-aged people. A persistent increase in complicated cases with a generalized spread of pathological elements was revealed, which proves the relevance of searching for new methods for managing these patients.
Morphofunctional status of interstitial endocrinocytes (Leydig cells) with premature aging caused by dark deprivation
Authors: Kondakova Larisa I. , Kalashnikova Svetlana A. , Polyakova Lyudmila V.
Published: July 2023

It was found that in experimental rats there is a decrease in the number of Leydig cells, the ratio between active and inactive endocrinocytes and, as a consequence, a decrease in the activity index of his cells. The effect of 30-day dark deprivation and 14-day correction with exogenous melatonin on the steroidogenic ability and morphofunctional state of the spermatogenic epithelium of the testes, interstitial endocrinocytes (Leydig cells) of white mongrel male rats aged 4 months was analyzed. The level of corticosterone, testosterone, and Clotho protein in blood serum was assessed by enzyme immunoassay. It was found that 30-day dark deprivation increases the level of corticosterone, reduces the level of testosterone and Clotho protein in the blood serum, which is a marker of premature aging. It was found that morphological changes in the testes were characterized by a decrease in the thickness of the spermatogenic epithelium, the area of Leydig cells and their nuclei for 30 days after dark deprivation. The introduction of exogenous melatonin led to a partial restoration of androgenogenesis, the morphofunctional state of the testes: spermatogenic epithelium, Leydig cells.