bluuebunny/crossref_metadata_2025 huggingface dataset:
A Drug Screening Reveals Minocycline Hydrochloride as a Therapeutic Option to Prevent Breast Cancer Cells Extravasation across the Blood–Brain Barrier
Authors: Godinho-Pereira Joana , Lopes Margarida Dionísio , Garcia Ana Rita , Botelho Hugo M. , Malhó Rui , Figueira Inês , Brito Maria Alexandra
Published: August 2022

Among breast cancer (BC) patients, 15–25% develop BC brain metastases (BCBM), a severe condition due to the limited therapeutic options, which points to the need for preventive strategies. We aimed to find a drug able to boost blood–brain barrier (BBB) properties and prevent BC cells (BCCs) extravasation, among PI3K, HSP90, and EGFR inhibitors and approved drugs. We used BCCs (4T1) and BBB endothelial cells (b.End5) to identify molecules with toxicity to 4T1 cells and safe for b.End5 cells. Moreover, we used those cells in mixed cultures to perform a high-throughput microscopy screening of drugs’ ability to ameliorate BBB properties and prevent BCCs adhesion and migration across the endothelium, as well as to analyse miRNAs expression and release profiles. KW-2478, buparlisib, and minocycline hydrochloride (MH) promoted maximal expression of the junctional protein β-catenin and induced 4T1 cells nucleus changes. Buparlisib and MH further decreased 4T1 adhesion. MH was the most promising in preventing 4T1 migration and BBB disruption, tumour and endothelial cytoskeleton-associated proteins modifications, and miRNA deregulation. Our data revealed MH’s ability to improve BBB properties, while compromising BCCs viability and interaction with BBB endothelial cells, besides restoring miRNAs’ homeostasis, paving the way for MH repurposing for BCBM prevention.
Autologous Platelet-Rich Growth Factor Reduces M1 Macrophages and Modulates Inflammatory Microenvironments to Promote Sciatic Nerve Regeneration
Authors: Yadav Anjali , Ramasamy Thamil Selvee , Lin Sheng-Che , Chen Szu-Han , Lu Jean , Liu Ya-Hsin , Lu Fu-I , Hsueh Yuan-Yu , Lin Shau-Ping , Wu Chia-Ching
Published: August 2022

The failure of peripheral nerve regeneration is often associated with the inability to generate a permissive molecular and cellular microenvironment for nerve repair. Autologous therapies, such as platelet-rich plasma (PRP) or its derivative platelet-rich growth factors (PRGF), may improve peripheral nerve regeneration via unknown mechanistic roles and actions in macrophage polarization. In the current study, we hypothesize that excessive and prolonged inflammation might result in the failure of pro-inflammatory M1 macrophage transit to anti-inflammatory M2 macrophages in large nerve defects. PRGF was used in vitro at the time the unpolarized macrophages (M0) macrophages were induced to M1 macrophages to observe if PRGF altered the secretion of cytokines and resulted in a phenotypic change. PRGF was also employed in the nerve conduit of a rat sciatic nerve transection model to identify alterations in macrophages that might influence excessive inflammation and nerve regeneration. PRGF administration reduced the mRNA expression of tumor necrosis factor-α (TNFα), interleukin-1β (IL-1β), and IL-6 in M0 macrophages. Increased CD206 substantiated the shift of pro-inflammatory cytokines to the M2 regenerative macrophage. Administration of PRGF in the nerve conduit after rat sciatic nerve transection promoted nerve regeneration by improving nerve gross morphology and its targeted gastrocnemius muscle mass. The regenerative markers were increased for regrown axons (protein gene product, PGP9.5), Schwann cells (S100β), and myelin basic protein (MBP) after 6 weeks of injury. The decreased expression of TNFα, IL-1β, IL-6, and CD68+ M1 macrophages indicated that the inflammatory microenvironments were reduced in the PRGF-treated nerve tissue. The increase in RECA-positive cells suggested the PRGF also promoted angiogenesis during nerve regeneration. Taken together, these results indicate the potential role and clinical implication of autologous PRGF in regulating inflammatory microenvironments via macrophage polarization after nerve transection.
A Transformable Sheet Type Robot That Can Be Thrown from the Air
Authors: Iida Naoki , Matsumoto Mitsuharu
Published: August 2022

This paper reports on a transformable sheet type robot that can be thrown from the air. Since sheet type robots can change their own shape and perform tasks according to the situation, they are expected to play an active role in situations with many restrictions, such as disaster-stricken areas. However, since most sheet type robots jump or crawl on the ground, the only way to deliver them to the site of a disaster is to transport them by vehicle or transporter. This research aims to develop a device that can be dispersed from the sky and perform activities on the ground after landing.
Numerical Simulation of Lap-Spliced Ultra-High-Performance Concrete Beam Based on Bond–Slip
Authors: Xu Zhenming , Huang Yuan , Liang Rui
Published: August 2022

In this paper, 3D finite element simulations were conducted for lap-spliced ultra-high-performance concrete (UHPC) beams using ABAQUS software. Based on the concrete damaged plasticity (CDP) model, the plastic damage factor was introduced to simulate the material properties of UHPC. The nonlinear characteristics of the steel bar and UHPC were considered, and the bond–slip constitutive relationship was selected to evaluate the bond–slip between the lap-spliced steel bar and UHPC. The simulated load–deflection curve, peak load, bond strength, and failure mode were in good agreement with the experimental results. The verified finite element model was used to analyze the parameters of the lap-spliced UHPC beam. The effects of lap-spliced steel bar diameter, stirrup spacing of non-lap segment, and shear span ratio on the mechanical properties and bond properties of the lap-spliced UHPC beam were studied. This study can provide a reference for the future simulation and design of lap-spliced UHPC beams.
Improvement of Bacterial Blight Resistance in Two Conventionally Cultivated Rice Varieties by Editing the Noncoding Region
Authors: Li Changyan , Zhou Lei , Wu Bian , Li Sanhe , Zha Wenjun , Li Wei , Zhou Zaihui , Yang Linfeng , Shi Lei , Lin Yongjun , You Aiqing
Published: August 2022

xa13 is a recessive pleiotropic gene that positively regulates rice disease resistance and negatively regulates rice fertility; thus, seriously restricting its rice breeding application. In this study, CRISPR/Cas9 gene-editing technology was used to delete the Xa13 gene promoter partial sequence, including the pathogenic bacteria-inducible expression element. Rice with the edited promoter region lost the ability for pathogen-induced gene expression without affecting background gene expression in leaves and anthers, resulting in disease resistance and normal yield. The study also screened a family of disease-resistant and normal fertile plants in which the target sequence was deleted and the exogenous transgene fragment isolated in the T1 generation (transgene-free line). Important agronomic traits of the T2 generation rice were examined. T2 generation rice with/without exogenous DNA showed no statistical differences compared to the wild type in heading stage, plant height, panicles per plant, panicle length, or seed setting rate in the field. Two important conventional rice varieties, namely Kongyu131 (KY131, Geng/japonica) and Huanghuazhan (HHZ, Xian/indica), were successfully transformed, and disease-resistant and fertile materials were obtained. Currently, these are the two important conventional rice varieties in China that can be used directly for production after improvement. Expression of the Xa13 gene in the leaves of transgenic rice (KY-PD and HHZ-PD) was not induced after pathogen infection, indicating that this method can be used universally and effectively to promote the practical application of xa13, a recessive disease-resistant pleiotropic gene, for rice bacterial blight resistance. Our study on the regulation of gene expression by editing noncoding regions of the genes provides a new idea for the development of molecular design breeding in the future.
New Insights on the Regulation of the Insulin-Degrading Enzyme: Role of microRNAs and RBPs
Authors: Martín-Martín Yolanda , Pérez-García Ana , Torrecilla-Parra Marta , Fernández-de Frutos Mario , Pardo-Marqués Virginia , Casarejos María José , Busto Rebeca , Ramírez Cristina M.
Published: August 2022

The evident implication of the insulin-degrading enzyme (IDE) in Alzheimer’s disease (AD) and type 2 diabetes mellitus (T2DM), among its capacity to degrade insulin and amyloid-β peptide (Aβ), suggests that IDE could be an essential link in the relation between hyperinsulinemia, insulin resistance and AD. However, little is known about the cellular and molecular regulation of IDE expression, and even less has been explored regarding the post-transcriptional regulation of IDE, although it represents a great molecular target of interest for therapeutic treatments. We recently described that miR-7, a novel candidate for linking AD and T2DM at the molecular level, regulates IDE and other key genes in both pathologies, including some key genes involved in the insulin signaling pathway. Here, we explored whether other miRNAs as well as other post-transcriptional regulators, such as RNA binding proteins (RBP), could potentially participate in the regulation of IDE expression in vitro. Our data showed that in addition to miR-7, miR-125, miR-490 and miR-199 regulate IDE expression at the post-transcriptional level. Moreover, we also found that IDE contains multiple potential binding sites for several RBPs, and a narrow-down prediction analysis led us to speculate on a novel regulation of IDE by RALY and HuD. Taken together, these results demonstrate the novel players controlling IDE expression that could represent potential therapeutical targets to treat several metabolic diseases with a high impact on human health, including AD and T2DM.
Comparison of Two Software Packages for Perfusion Imaging: Ischemic Core and Penumbra Estimation and Patient Triage in Acute Ischemic Stroke
Authors: Zhou Xiang , Nan Yashi , Ju Jieyang , Zhou Jingyu , Xiao Huanhui , Wang Silun
Published: August 2022

Purpose: Automated postprocessing packages have been developed for managing acute ischemic stroke (AIS). These packages identify ischemic core and penumbra using either computed tomographic perfusion imaging (CTP) data or magnetic resonance imaging (MRI) data. Measurements of abnormal tissues and treatment decisions derived from different vendors can vary. The purpose of this study is to investigate the agreement of volumetric and decision-making outcomes derived from two software packages. Methods: A total of 594 AIS patients (174 underwent CTP and 420 underwent MRI) were included. Imaging data were accordingly postprocessed by two software packages: RAPID and RealNow. Volumetric outputs were compared between packages by performing intraclass correlation coefficient (ICC), Wilcoxon paired test and Bland–Altman analysis. Concordance of selecting patients eligible for mechanical thrombectomy (MT) was assessed based on neuroimaging criteria proposed in DEFUSE3. Results: In the group with CTP data, mean ischemic core volume (ICV)/penumbral volume (PV) was 14.9/81.1 mL via RAPID and 12.6/83.2 mL via RealNow. Meanwhile, in the MRI group, mean ICV/PV were 52.4/68.4 mL and 48.9/61.6 mL via RAPID and RealNow, respectively. Reliability, which was measured by ICC of ICV and PV in CTP and MRI groups, ranged from 0.87 to 0.99. The bias remained small between measurements (CTP ICV: 0.89 mL, CTP PV: −2 mL, MRI ICV: 3.5 mL and MRI PV: 6.8 mL). In comparison with CTP ICV with follow-up DWI, the ICC was 0.92 and 0.94 for RAPID and Realnow, respectively. The bias remained small between CTP ICV and follow-up DWI measurements (Rapid: −4.65 mL, RealNow: −3.65 mL). Wilcoxon paired test showed no significant difference between measurements. The results of patient triage were concordant in 159/174 cases (91%, ICC: 0.90) for CTP and 400/420 cases (95%, ICC: 0.93) for MRI. Conclusion: The CTP ICV derived from RealNow was more accurate than RAPID. The similarity in volumetric measurement between packages did not necessarily relate to equivalent patient triage. In this study, RealNow showed excellent agreement with RAPID in measuring ICV and PV as well as patient triage.
Non-Alcoholic Steatohepatitis (NASH) and Liver Fibrosis: Molecular and Multicellular Control of Evolving Diseased States
Authors: Eeckhoute Jérôme
Published: August 2022

Non-alcoholic fatty liver disease (NAFLD), the most common chronic liver disease, has emerged as a major threat to public health [...]
NREM Parasomnias: Retrospective Analysis of Treatment Approaches and Comorbidities
Authors: Limbekar Naina , Pham Jonathan , Budhiraja Rohit , Javaheri Sogol , Epstein Lawrence J. , Batool-Anwar Salma , Pavlova Milena
Published: August 2022

The aim of this retrospective analysis is to determine the most frequently prescribed medications for the treatment of NREM parasomnias and evaluate reported outcomes. We performed a retrospective chart review of all patients with NREM parasomnia diagnosed within Brigham and Women’s Hospital (BWH) clinics examining the date of diagnosis, date of starting therapy, comorbidities, type of medication prescribed, and the reported change in symptoms or side effects at follow-up visits. From 2012 to 2019, 110 patients (59 females, 51 male) at BWH clinics received a diagnosis of NREM parasomnia, including sleepwalking and night terrors. The mean age was 44. Comorbidities included obstructive sleep apnea (OSA) (46%), periodic limb movement syndrome (PLMS) (13%), insomnia (19%), Restless leg syndrome (RLS) (9%), epilepsy (4%), and REM behavior disorder (RBD) (9%). Initial treatment strategies include behavioral and safety counseling only (34%), pharmacological treatment (29%), treatment of any comorbidity (28%), and combined treatment of any of the above (9%). Improvement was reported with: treatment of OSA (n = 23 52% reported improvement), melatonin (n = 8, improvement reported by 88%.,benzodiazepine (n = 7, improvement reported by 57%). Treating comorbid conditions is a frequent treatment strategy, often associated with symptom improvement. The pharmacologic treatment most commonly included melatonin and benzodiazepines. Comprehensive management should include behavioral and safety recommendations, assessment of comorbid conditions, and individually tailored pharmaceutical treatment.
RETRACTED: El-Megharbel et al. Utilizing of (Zinc Oxide Nano-Spray) for Disinfection against “SARS-CoV-2” and Testing Its Biological Effectiveness on Some Biochemical Parameters during (COVID-19 Pandemic)—“ZnO Nanoparticles Have Antiviral Activity against (SARS-CoV-2)”. Coatings 2021, 11, 388
Authors: El-Megharbel Samy , Alsawat Mohammed , Al-Salmi Fawziah , Hamza Reham
Published: August 2022

The journal retracts the article “Utilizing of (Zinc Oxide Nano-Spray) for Disinfection against “SARS-CoV-2” and Testing Its Biological Effectiveness on Some Biochemical Parameters during (COVID-19 Pandemic)—“ZnO Nanoparticles Have Antiviral Activity against (SARS-CoV-2)” Coatings 2021, 11, 388” [...]
RETRACTED: Hamza et al. A Potential Role of Apelin-13 against Hepatic Injury and Metabolic Disorders in Preeclampsia Induced by L-NAME. Coatings 2021, 11, 391
Authors: Hamza Reham , Diab Abdel , Zahra Mansour , Attia Mai , Moursi Suzan , Al-Baqami Najah
Published: August 2022

The journal retracts the article “A Potential Role of Apelin-13 against Hepatic Injury and Metabolic Disorders in Preeclampsia Induced by L-NAME [...]
RETRACTED: Al-Thubaiti et al. Safety of Commercially Available Beef Burger in Saudi Arabia. Coatings 2021, 11, 686
Authors: Al-Thubaiti Eman , Shaikh Omar Abdulkader , El-Omri Abdelfatteh , Al-Matary Mohammed , Al-Mwallad Ali , Eldeeb Seham
Published: August 2022

The journal retracts the article, “Safety of Commercially Available Beef Burger in Saudi Arabia [...]
RETRACTED: Hamza et al. Therapeutic and Ameliorative Effects of Active Compounds of Combretum molle in the Treatment and Relief from Wounds in a Diabetes Mellitus Experimental Model. Coatings 2021, 11, 324
Authors: Hamza Reham , Al-Motaani Shaden , Al-Talhi Tarek
Published: August 2022

The journal retracts the article, “Therapeutic and Ameliorative Effects of Active Compounds of Combretum molle in the Treatment and Relief from Wounds in a Diabetes Mellitus Experimental Model [...]
RETRACTED: Hamza et al. Neurological Alterations and Testicular Damages in Aging Induced by D-Galactose and Neuro and Testicular Protective Effects of Combinations of Chitosan Nanoparticles, Resveratrol and Quercetin in Male Mice. Coatings 2021, 11, 435
Authors: Hamza Reham , Al-Harbi Mohammad , Al-Hazaa Munirah
Published: August 2022

The journal retracts the article “Neurological Alterations and Testicular Damages in Aging Induced by D-Galactose and Neuro and Testicular Protective Effects of Combinations of Chitosan Nanoparticles, Resveratrol and Quercetin in Male Mice [...]
Soft Sparking Discharge Mechanism of Micro-Arc Oxidation Occurring on Titanium Alloys in Different Electrolytes
Authors: Tang Qin , Qiu Tao , Ni Ping , Zhai Dajun , Shen Jun
Published: August 2022

Soft sparking during micro-arc oxidation can form a ceramic coating with high hardness and high bond strength on titanium alloy while avoiding the continuous strong micro-arc that can damage the substrate properties and the integrity of the coating. Existing studies have reported that the soft spark discharge is significantly influenced by the electrolyte anions, and the detailed mechanism of its influence remains unclear. Therefore, we considered four monolithic electrolytes, namely Na2B4O7, NaF, Na3PO4, and Na2SiO3, for the bipolar pulsed micro-arc oxidation (MAO) treatment of the Ti6Al4V alloy to investigate the mechanism of the soft sparking discharge and the affections of different electrolytes on the soft sparking discharge. The results showed that soft spark discharges were observed in both Na2SiO3 and Na3PO4 electrolytes while not in Na2B4O7 and NaF electrolytes. We attributed this situation to the fact that the deposition of Si and P elements in the coating changed the structure and passivation ability of the coating and affected the rate of ion transport and electron tunneling in the coating, resulting in forming a thick and dense, soft spark MAO inner layer. Additionally, the soft sparking discharge facilitated particle deposition and did not destroy the structure of the initial film layer, and also had no significant effect on the corrosion resistance.
Characterization of KrF Excimer Laser Ablation of Cadmium in Different Liquids for Biomedical and Industrial Applications
Authors: Umm-i-Kalsoom  , Ali Nisar , Bashir Shazia , Alshehri Ali Mohammad , Begum Narjis
Published: August 2022

Liquid-assisted laser ablation (LALA) has gained substantial attention as a method that can achieve desired chemical and physical properties. The fabrication of carbides (CdCO3), oxides (CdO), and hydro-oxides (Cd(OH)2) on Cd surfaces make them more useful in industrial and biomedical applications due to the enhancement of their physical properties. For this purpose, LALA of Cadmium (Cd) is performed using a KrF Excimer laser (248 nm, 20 ns) at varying numbers of pulses from 500 to 2000 at constant fluence (3.6 Jcm−2) in deionized water (DI) and ethanol. A comparison of the ablation behavior of Cd in DI water and alcohol (ethanol) environments is discussed in the present work. The surface structuring and enhancement of mechanical properties are also discussed in correlation with the changes produced in its crystallinity due to the increase in the chemical reactivity of Cd in both ambient environments. The surface features, chemical composition, structural and compositional analysis, and mechanical properties of irradiated targets are evaluated using a Scanning Electron Microscope (SEM), X-ray Diffraction (XRD), Fast Fourier Transform Infrared spectroscopic (FTIR), Energy Dispersive X-ray Spectroscopy (EDS), and a Nano-hardness tester. Pores, cavities, hillocks, wave-like ridges, nanoparticles, flake-like structures, and periodic surface structures are distinguished features on the Cd surface after irradiation. However, the density and size of pores and cavities are higher in water, whereas ethanol is favorable for the growth of craters and ripples. These features are attributable to various thermal and chemical phenomena induced by laser heating at the solid–liquid interface. Ethanol-assisted ablation is more favorable for enhancing the hardness of Cd as compared to DI water-assisted ablation due to the presence of maximum compressive stresses and minimum crystallite size (C.S.) caused by the diffusion of carbon into the target surface.
Current Transition of Nucleation and Growth under Diffusion-Controlled Electrocrystallization: A Brief Review
Authors: Luo Gong , Yuan Yuan , Li De-Yu , Li Ning , Yuan Guo-Hui
Published: August 2022

A brief review is given on the current transition of the electrodeposition of materials by a mechanism of nucleation followed by diffusion-controlled growth. A short historical background to study the nucleation and growth by diffusion-controlled electrocrystallization is provided. Then, an outline of the major potentiostatic current transient modeling is given, with some comments on their relative merits. Finally, a summary of the current transition functions of nucleation and growth under diffusion-controlled electrocrystallization is given including the theoretical models that have been recently applied.
Corrosion Mechanism and the Effect of Corrosion Time on Mechanical Behavior of 5083/6005A Welded Joints in a NaCl and NaHSO3 Mixed Solution
Authors: Chen Yuqiang , Wu Hailiang , Wang Xiangdong , Zeng Xianghao , Huang Liang , Gu Hongyu , Li Heng
Published: August 2022

The effect of corrosion time on the mechanical behavior of 5083/6005A welded joints in a 3.5% NaCl + 0.01 mol/L NaHSO3 solution was evaluated via scanning electron microscopy (SEM), polarization curve analysis, and X-ray photoelectron spectroscopy (XPS). The prediction model of fatigue life after corrosion was established based on the experimental results and the theory of fracture mechanics, and the formula for the effect of corrosion time on lifespan was determined. The results show that with increasing corrosion time, the corrosion of the sample becomes increasingly severe, and the elongation and fatigue life of the 5083/6005A welded joints decrease significantly. The corrosion resistance of the 5083/6005A welded joints decreases with increasing corrosion time because the corrosive medium promotes the destruction of the oxide film and thereby reduces the corrosion resistance. The corrosion products of the 5083/6005A welded joints are Al(OH)3 and AlCl3.
Saturation Spectroscopic Studies on Yb3+ and Er3+ Ions in Li6Y(BO3)3 Single Crystals
Authors: Mandula Gábor , Kis Zsolt , Lengyel Krisztián , Kovács László , Tichy-Rács Éva
Published: August 2022

The results of a series of pump–probe spectral hole-burning experiments are presented on Yb3+- or Er3+-doped Li6Y(BO3)3 (LYB) single crystals in the temperature range of 2–14 K and 9–28 K, respectively. The spectral hole has a complex structure for Yb3+ with superposed narrow and broad bands, while a single absorption hole has been observed for Er3+. Population relaxation times (T1) at about 850 ± 60 μs and 1010 ± 50 μs and dipole relaxation times (T2) with values of 1100 ± 120 ns and 14.2 ± 0.3 ns have been obtained for the two components measured for the Yb3+:2F7/2—2F5/2 transition. T1 = 402 ± 8 μs and T2 = 11.9 ± 0.2 ns values have been found for the Er3+:4I15/2—4I11/2 excitation. The spectral diffusion rate at about 1 and 5 MHz/ms has been determined for the narrow and broad spectral line in Yb3+-doped crystal, respectively. The temperature dependence of the spectral hole halfwidth has also been investigated.
Diagnostic Dilemma of Biliopancreatic Contrast-Enhanced Harmonic Endoscopic Ultrasonography
Authors: Kanazawa Keisuke , Chiba Masafumi , Kato Masayuki , Kinoshita Yuji , Akasu Takafumi , Matsui Hiroaki , Shimamoto Nana , Tomita Youichi , Abe Takahiro , Tsukinaga Shintaro , Nakano Masanori , Torisu Yuichi , Toyoizumi Hirobumi , Sumiyama Kazuki
Published: August 2022

Background: The utility of contrast-enhanced harmonic endoscopic ultrasonography (CH-EUS) alone in the biliopancreatic region appears to be limited because it is highly dependent on the experience and skill of the endoscopist. Therefore, the present study aimed to validate the efficacy of CH-EUS in clinical practice. Methods: Between January 2018 and March 2019, 301 consecutive patients who underwent CH-EUS were prospectively enrolled in this study. The diagnostic performance of CH-EUS was compared with that of dynamic computed tomography (CT), magnetic resonance imaging (MRI), and all combinations (i.e., CH-EUS, dynamic CT, and MRI) using a Bonferroni correction. A multiple logistic regression analysis was performed to extract each disease that allowed the CH-EUS diagnosis to be consistent with the final diagnosis. Results: In multiple comparisons of diagnostic performance, no significant differences were observed among dynamic CT, MRI, and CH-EUS (p = 1.00), but the diagnostic performance was significantly higher when all modalities were combined (p < 0.001). Moreover, only intraductal papillary mucinous neoplasm comprising adenoma or carcinoma (IPMN, n = 161) showed significance with respect to the agreement with the final diagnosis (p = 0.006). Conclusions: Our results showed that CH-EUS-based diagnosis of IPMN may be possible in clinical practice. On the contrary, to accurately diagnose biliopancreatic diseases other than IPMN, comprehensive diagnosis using multiple modalities may be necessary, rather than relying on CH-EUS alone.
Role of Multiparametric Intestinal Ultrasound in the Evaluation of Response to Biologic Therapy in Adults with Crohn’s Disease
Authors: Puca Pierluigi , Del Vecchio Livio Enrico , Ainora Maria Elena , Gasbarrini Antonio , Scaldaferri Franco , Zocco Maria Assunta
Published: August 2022

Crohn’s disease is one of the two most common types of inflammatory bowel disease. Current medical therapies are based on the use of glucocorticoids, exclusive enteral nutrition, immunosuppressors such as azathioprine and methotrexate, and biological agents such as infliximab, adalimumab, vedolizumab, or ustekinumab. International guidelines suggest regular disease assessment and surveillance through objective instruments to adjust and personalize the therapy, reducing the overall rates of hospitalization and surgery. Although endoscopy represents the gold-standard for surveillance, its frequent use is strongly bordered by associated risks and costs. Consequently, alternative non-invasive tools to objectify disease activity and rule active inflammation out are emerging. Alongside laboratory exams and computed tomography or magnetic resonance enterography, intestinal ultrasonography (IUS) shows to be a valid choice to assess transmural inflammation and to detect transmural healing, defined as bowel wall thickness normalization, no hypervascularization, normal stratification, and no creeping fat. Compared to magnetic resonance imaging (MRI) or computed tomography, CT scan, IUS is cheaper and more widespread, with very similar accuracy. Furthermore, share wave elastography, color Doppler, and contrast-enhanced ultrasonography (CEUS) succeed in amplifying the capacity to determine the disease location, disease activity, and complications. This review aimed to discuss the role of standard and novel ultrasound techniques such as CEUS, SICUS, or share wave elastography in adults with Crohn’s disease, mainly for therapeutic monitoring and follow-up.
Design of a UAV for Autonomous RFID-Based Dynamic Inventories Using Stigmergy for Mapless Indoor Environments
Authors: Alajami Abdussalam A. , Moreno Guillem , Pous Rafael
Published: August 2022

Unmanned aerial vehicles (UAVs) and radio frequency identification (RFID) technology are becoming very popular in the era of Industry 4.0, especially for retail, logistics, and warehouse management. However, the autonomous navigation for UAVs in indoor map-less environments while performing an inventory mission is, to this day, an open issue for researchers. This article examines the method of leveraging RFID technology with UAVs for the problem of the design of a fully autonomous UAV used for inventory in indoor spaces. This work also proposes a solution for increasing the performance of the autonomous exploration of inventory zones using a UAV in unexplored warehouse spaces. The main idea is to design an indoor UAV equipped with an onboard autonomous navigation system called RFID-based stigmergic and obstacle avoidance navigation system (RFID-SOAN). RFID-SOAN is composed of a computationally low cost obstacle avoidance (OA) algorithm and a stigmergy-based path planning and navigation algorithm. It uses the same RFID tags that retailers add to their products in a warehouse for navigation purposes by using them as digital pheromones or environmental clues. Using RFID-SOAN, the UAV computes its new path and direction of movement based on an RFID density-oriented attraction function, which estimates the optimal path through sensing the density of previously unread RFID tags in various directions relative to the pose of the UAV. We present the results of the tests of the proposed RFID-SOAN system in various scenarios. In these scenarios, we replicate different typical warehouse layouts with different tag densities, and we illustrate the performance of the RFID-SOAN by comparing it with a dead reckoning navigation technique while taking inventory. We prove by the experiments results that the proposed UAV manages to adequately estimate the amount of time it needs to read up-to 99.33% of the RFID tags on its path while exploring and navigating toward new zones of high populations of tags. We also illustrate how the UAV manages to cover only the areas where RFID tags exist, not the whole map, making it very efficient, compared to the traditional map/way-points-based navigation.
Towards A Socioeconomic Model of Sleep Health among the Canadian Population: A Systematic Review of the Relationship between Age, Income, Employment, Education, Social Class, Socioeconomic Status and Sleep Disparities
Authors: Etindele Sosso F. A. , Kreidlmayer Marta , Pearson Dess , Bendaoud Imene
Published: August 2022

A better understanding of the contribution of the socioeconomic status (SES) in sleep health could guide the development of population-based interventions aiming to reduce “the silent public health issue” that are sleep disturbances. PRISMA was employed to identify relevant studies having examined the association between social class, social capital, education, income/assets, occupation/employment status, neighborhood deprivation and sleep health. Sixteen cross-sectional and three longitudinal studies were selected, having sampled 226,029 participants aged from 2 months to 85 years old. Findings showed that: (1) sleep health disparities among children and adolescent are strongly correlated to parental socioeconomic indicators; (2) poor parental income, poor family SES and poor parental education are associated with higher sleep disturbances among children and adolescents; (3) lower education is a predictor of increased sleep disturbances for adults; (4) low SES is associated with high sleep disturbances in adults and old people and; (5) low income and full-time employment was significantly associated with short sleep among adults and old people. In conclusion, sleep health should be an important public health target. Such intervention would be beneficial for populational health, for all taxpayers and public administrations, which would see a reduction in absenteeism and productivity losses attributable to sleep-related health problems in the global economy.
Subclinical Reactive Hypoglycemia Is Associated with Higher Eating and Snacking Frequencies in Obese or Overweight Men without Diabetes
Authors: Kishimoto Ichiro , Ohashi Akio
Published: August 2022

Impacts of subclinical reactive hypoglycemia on food ingestion are not well studied. In the present study, in obese/overweight males without diabetes (n = 34), continuous glucose monitoring and eating behavior were recorded for 6 days after the 75 g glucose challenge. In 50% of subjects, the minimal sensor glucose levels within 24 h post-challenge (CGMmin) were <70 mg/dL, while symptoms, if any, were subtle. Median eating and snacking frequencies were 3.45 and 0.45 times/day, respectively. In subjects with eating frequency > 3 times/day, CGMmin was significantly lower than CGMmin in those without. The receiver operating characteristic curve of CGMmin for detecting eating frequency > 3 times/day showed the area under the curve of 0.74 with the cutoff point of 65 mg/dL (p = 0.027). Eating frequency of subjects with CGMmin < 65 mg/dL was significantly higher than that of subjects with CGMmin ≥ 65 mg/dL (3.68 vs. 3.3 times/day, p = 0.047). When it was defined as reactive hypoglycemia that either the 2 h post-load blood glucose level, the minimal self-monitored blood glucose level within the 1st day, or CGMmin, was below their respective cutoff for detecting eating frequency > 3 times/day, eating frequency of subjects with the reactive hypoglycemia was significantly higher than that of the subjects without the reactive hypoglycemia (3.75 times/day vs. 3.15 times/day, p = 0.001). In addition, the median snacking frequency was 6 times higher in subjects with reactive hypoglycemia compared to those without it (0.9 times/day vs. 0.15 times/day, p < 0.001). In conclusion, in obese/overweight males without diabetes, subclinical reactive hypoglycemia is significantly associated with higher eating/snacking frequencies.
Biohydrogen and Methane Production from Sugarcane Leaves Pretreated by Deep Eutectic Solvents and Enzymatic Hydrolysis by Cellulolytic Consortia
Authors: Miftah Apik Khautsart , Sittijunda Sureewan , Imai Tsuyoshi , Salakkam Apilak , Reungsang Alissara
Published: August 2022

This study determined the optimal conditions for the deep eutectic solvent (DES) pretreatment of sugarcane leaves and the best fermentation mode for hydrogen and methane production from DES-pretreated sugarcane leaves. Choline chloride (ChCl):monoethanolamine (MEA) is the most effective solvent for removing lignin from sugarcane leaves. The optimum conditions were a ChCl: MEA molar ratio of 1:6, 120 °C, 3 h, and substrate-to-DES solution ratio of 1:12. Under these conditions, 86.37 ± 0.36% lignin removal and 73.98 ± 0.42% hemicellulose removal were achieved, whereas 84.13 ± 0.77% cellulose was recovered. At a substrate loading of 4 g volatile solids (VS), the simultaneous saccharification and fermentation (SSF) and separate hydrolysis and fermentation (SHF) processes yielded maximum hydrogen productions of 3187 ± 202 and 2135 ± 315 mL H2/L, respectively. In the second stage, methane was produced using the hydrogenic effluent. SSF produced 5923 ± 251 mL CH4/L, whereas SHF produced 3583 ± 128 mL CH4/L. In a one-stage methane production process, a maximum methane production of 4067 ± 320 mL CH4/L with a substrate loading of 4 g VS was achieved from the SSF process. SSF proved to be more efficient than SHF for producing hydrogen from DES-pretreated sugarcane leaves in a two-stage hydrogen and methane production process as well as a one-stage methane production process.
Effect of Plasma Actuator on Velocity and Temperature Profiles of High Aspect Ratio Rectangular Jet
Authors: Pham Anh Viet , Inaba Kazuaki , Saito Miyuki , Sakai Masaharu
Published: August 2022

The turbulence jet centerline velocity and temperature decay intensely along the centerline flow direction. Thus, improving it could benefit engineering applications, such as air conditioners. However, active flow control techniques with high-aspect-ratio jets, especially for controlling the temperature, have not been widely investigated. This paper presents the velocity and temperature performance of a high-aspect-ratio rectangular jet controlled by two dielectric barrier discharge plasma actuators located on the longer sides of the nozzle and controlled by high-voltage and high-frequency pulse-width modulation sinusoidal waves. The scanning method was used to cover 362 cases as combinations of working parameters (modular frequency vs. duty vs. phase difference) for the velocity and temperature performances of the jets. Results show that plasma actuators can control both velocity and temperature distribution with minor input power compared with the rectangular jet’s kinetic energy and heat flux. The velocity increased up to 4% and decreased to 11%, measured at the interest position where x/h = 70 on the centerline. There were a 5% increase and a 4% decrease compared to the temperature-based case. Distinctive velocity and temperature distributions were observed under noteworthy cases, indicating the potential of the actuator to create various flow features without installing new hardware on the flow.
Sorghum Flour Application in Bread: Technological Challenges and Opportunities
Authors: Ari Akin Pervin , Demirkesen Ilkem , Bean Scott R. , Aramouni Fadi , Boyaci Ismail Hakkı
Published: August 2022

Sorghum has a long history of use in the production of different types of bread. This review paper discusses different types of bread and factors that affect the physicochemical, technological, rheological, sensorial, and nutritional properties of different types of sorghum bread. The main types of bread are unleavened (roti and tortilla), flatbread with a pre-ferment (injera and kisra), gluten-free and sorghum bread with wheat. The quality of sorghum flour, dough, and bread can be improved by the addition of different ingredients and using novel and traditional methods. Furthermore, extrusion, high-pressure treatment, heat treatment, and ozonation, in combination with techniques such as fermentation, have been reported for increasing sorghum functionality.
The Relationships between Food Literacy, Health Promotion Literacy and Healthy Eating Habits among Young Adults in South Korea
Authors: Lee Yoojin , Kim Taehee , Jung Hyosun
Published: August 2022

The obesity problem has reached a critical level and is threatening not only personal health but also public health systems around the world. Obesity in young adults is especially rapidly growing and many studies have confirmed that the best prevention is developing healthy eating habits with the improvement of food and health promotion literacy competencies. In this context, this study diagnoses the present levels of food literacy and health promotion literacy among young adults and explores the relationships between both literacies and their healthy eating habits. A total of 325 young adults in South Korea participated in this research, and the results are as follows. First, all food literacy components, which are food and nutrition knowledge, food skills, and resilience, are positively associated with healthy eating habits. Second, health promotion literacy is also positively associated with young adults’ healthy eating habits. Lastly, unlike the primary information sources, gender has a moderating effect on the relationships between both literacies and healthy eating habits. This indicates that the government and educational sectors should propose more policy supports and solid education systems in order to help young adults develop their food and health promotion literacies for overall well-being in the future.
Cannabis Use in Autism: Reasons for Concern about Risk for Psychosis
Authors: Bortoletto Riccardo , Colizzi Marco
Published: August 2022

Being particularly vulnerable to the pro-psychotic effects of cannabinoid exposure, autism spectrum individuals present with an increased risk of psychosis, which may be passed on to their own children. More specifically, cannabis exposure among autism spectrum individuals seems to exert disruptive epigenetic effects that can be intergenerationally inherited in brain areas which play a critical role in schizophrenia pathophysiology. Additionally, because of such cannabinoid-induced epigenetic effects, autism candidate genes present with bivalent chromatin markings which make them more vulnerable to subsequent disruption, possibly leading to psychosis onset later in life. Thus, findings support a developmental trajectory between autism and psychosis, as per endocannabinoid system modulation. However, such evidence has not received the attention it deserves.
The Importance of Skills Training for Service Users in Health Care: A Comparative Analysis
Authors: Rudnick Abraham
Published: August 2022

Health care and other human services such as education are diverse in many substantive aspects. However, arguably, they all use the skills training of service users to accomplish at least some of their key aims. This brief article uses a selective literature review and a comparative analysis to review the commonalities of skills training of service users in health care and education in order to illustrate and argue for the importance of a skills training approach in health care and other human services (recognizing that complementary approaches such as support provision are needed too and that not all service users need skills training). Research and development is needed in this area.
Cleft Orthodontic Care in Europe: A Cross-Sectional Survey
Authors: Francisco Inês , Antonarakis Gregory S. , Caramelo Francisco , Fernandes Maria Helena , Vale Francisco
Published: August 2022

(1) Background: Orthodontists have an important role in cleft care. Over the two decades since the Eurocleft studies, a significant improvement in healthcare systems has been achieved but there has been no critical assessment regarding the establishment of proposed standard protocols. This study aimed to describe the current provider characteristics, orthodontic appliances, services offered, orthodontic complications, and cost analysis of cleft treatment in Europe. (2) Methods: A cross-sectional 22-question online survey, accessible from January 2021 to July 2021, was sent to 214 practitioners, pertaining to provider characteristics, orthodontic appliances, services offered, orthodontic complications, and cost analysis. Descriptive statistics were calculated for each question. Fisher’s exact test was used to assess the association between categorical variables. (3) Results: A total of 79 responses from 23 European countries completed the survey (response rate = 37%), with 69 surveys being assessed after the exclusion of incomplete surveys. Rapid maxillary expansion was the preferred expansion protocol (45%). Distraction osteogenesis was the most reported alternative treatment to secondary bone grafts (19%), with private practitioners being less likely to perform these treatments (Fisher’s exact test, p = 0.001). Orthodontic services offered were, however, rather similar in the various locations of provision (hospital and/or university, private). Compromised oral hygiene (77%) was the most reported orthodontic complication. The National Health Services support the majority of cleft orthodontic care (67%) in Europe. (4) Conclusion: An apparent improvement in orthodontic healthcare provision has been achieved within Europe in the last two decades, but there are several discrepancies, namely regarding treatment timing and the appliances offered.
Lived Experiences of Domestic Violence in Women and Their Children: A Phenomenological Study
Authors: Lee Pei-Yu , Lee Bih-O
Published: August 2022

This study explores women and their children’s lived experience of domestic violence (DV). A qualitative phenomenological research approach was used. Data were collected by semi-structured interviews. Five women and five adult children participated in this study. COREQ reporting guidelines were utilized. Three main themes and six subthemes emerged from the interviews with the women; the main themes were “living with suffering”, “insecurity in daily life”, and “conformity in coping behaviors”. Two main themes and four subthemes were identified from the interviews with the children; the main themes were “barriers to learning and interactions with peers” and “a sense of threat to life”. The findings show that the women and their children had to cope with not only the DV itself but also the negative consequences of the violence. Several recommendations are made for the police and first-line healthcare and social work systems and to prevent DV by integrating the care provided to the family. The findings provide prevention and integration care for mothers and their children experiencing DV systematically.
Effect of Wolbachia Infection and Adult Food on the Sexual Signaling of Males of the Mediterranean Fruit Fly Ceratitis capitata
Authors: Kyritsis Georgios , Koskinioti Panagiota , Bourtzis Kostas , Papadopoulos Nikos
Published: August 2022

Sexual signaling is a fundamental component of sexual behavior of Ceratitis capitata that highly determines males’ mating success. Nutritional status and age are dominant factors known to affect males’ signaling performance and define the female decision to accept a male as a sexual partner. Wolbachia pipientis, a widespread endosymbiotic bacterium of insects and other arthropods, exerts several biological effects on its hosts. However, the effects of Wolbachia infection on the sexual behavior of medfly and the interaction between Wolbachia infection and adult food remain unexplored. This study was conducted to determine the effects of Wolbachia on sexual signaling of protein-fed and protein-deprived males. Our findings demonstrate that: (a) Wolbachia infection reduced male sexual signaling rates in both food regimes; (b) the negative effect of Wolbachia infection was more pronounced on protein-fed than protein-deprived males, and it was higher at younger ages, indicating that the bacterium regulates male sexual maturity; (c) Wolbachia infection alters the daily pattern of sexual signaling; and (d) protein deprivation bears significant descent on sexual signaling frequency of the uninfected males, whereas no difference was observed for the Wolbachia-infected males. The impact of our findings on the implementation of Incompatible Insect Technique (IIT) or the combined SIT/IIT towards controlling insect pests is discussed.
A Semi-Supervised Machine Learning Model to Forecast Movements of Moored Vessels
Authors: Romano-Moreno Eva , Tomás Antonio , Diaz-Hernandez Gabriel , Lara Javier L. , Molina Rafael , García-Valdecasas Javier
Published: August 2022

The good performance of the port activities in terminals is mainly conditioned by the dynamic response of the moored ship system at a berth. An adequate definition of the highly multivariate processes involved in the response of a moored ship at a berth is crucial for an appropriate characterization of port operability. The availability of an efficient forecast system of the movements of moored ships is essential for the planning, performance, and safety of the development of port operations. In this paper, an inference model to predict moored ship motions, based on a semi-supervised Machine Learning methodology, is presented. A comparison with different supervised and unsupervised Machine Learning techniques, as well as with existing Deep Learning-based models for predicting moored ship motions, has been performed. The highest performance of the semi-supervised Machine Learning-based model has been obtained. Additionally, the influence of infragravity wave parameters introduced as predictor variables in the model has been analyzed and compared with the typical ocean waves, wind, and sea level as predictor variables. The prediction model has been developed and validated with an available dataset of measured data from field campaigns in the Outer Port of Punta Langosteira (A Coruña, Spain).