bluuebunny/crossref_metadata_2025 huggingface dataset:
Relevance of Breast Cancer Resistance Protein to Pharmacokinetics of Florfenicol in Chickens: A Perspective from In Vivo and In Vitro Studies
Authors: Liu Yang , Guo Li , Zloh Mire , Zhang Yujuan , Huang Jinhu , Wang Liping
Published: October 2018

Florfenicol (FFC) is a valuable synthetic fluorinated derivative of thiamphenicol widely used to treat infectious diseases in food animals. The aims of the study were to investigate whether FFC is a substrate for the breast cancer resistance protein (BCRP) and whether the transporter influences oral availability of FFC. In vitro transport assays using MDCK-chAbcg2 cells were conducted to assess chicken BCRP-mediated transport of FFC, while in vivo pharmacokinetic experiments with single or combined BCRP inhibitor gefitinib were employed to study the role of BCRP in oral FFC disposition. According to U.S. Food and Drug Administration (FDA) criteria, FFC was found to be a potential BCRP substrate due to the net efflux ratio being over 2.0 (2.37) in MDCK cells stably transfected with chicken BCRP and the efflux completely reversed by a BCRP inhibitor (Gefitinib). The molecular docking results indicated that florfenicol can form favorable interactions with the binding pocket of homology modeled chicken BCRP. Pharmacokinetic studies of FFC in different aged broilers with different expression levels of BCRP showed that higher BCRP expression would cause a lower Area Under Curve (AUC) and a higher clearance of FFC. In addition, more extensive absorption of florfenicol after the co-administration with gefitinib (a BCRP inhibitor) was observed. The overall results demonstrated that florfenicol is a substrate of the chicken breast cancer resistant protein which in turn affects its pharmacokinetic behavior.
Allergen Delivery Inhibitors: Characterisation of Potent and Selective Inhibitors of Der p 1 and Their Attenuation of Airway Responses to House Dust Mite Allergens
Authors: Zhang Jihui , Chen Jie , Zuo Jie , Newton Gary K. , Stewart Mark R. , Perrior Trevor R. , Garrod David R. , Robinson Clive
Published: October 2018

Group 1 allergens of house dust mites (HDM) are globally significant triggers of allergic disease. They are considered as initiator allergens because their protease activity enables the development of allergy to a spectrum of unrelated allergens from various sources. This initiator-perpetuator function identifies Group 1 HDM allergens as attractive drug design targets for the first small-molecule approach directed towards a non-human, root cause trigger of allergic disease. The purpose of this study was to: (i) identify exemplar inhibitors of these allergens using Der p 1 as a design template, and (ii) characterise the pharmacological profiles of these compounds using in vitro and in vivo models relevant to allergy. Potent inhibitors representing four different chemotypes and differentiated by mechanism of action were investigated. These compounds prevented the ab initio development of allergy to the full spectrum of HDM allergens and in established allergy they inhibited the recruitment of inflammatory cells and blunted acute allergic bronchoconstriction following aerosol challenge with the full HDM allergen repertoire. Collectively, the data obtained in these experiments demonstrate that the selective pharmacological targeting of Der p 1 achieves an attractive range of benefits against exposure to all HDM allergens, consistent with the initiator-perpetuator function of this allergen.
Impact of Hyperbaric Oxygen Therapy on Subsequent Neurological Sequelae Following Carbon Monoxide Poisoning
Authors: Huang Chien-Cheng , Ho Chung-Han , Chen Yi-Chen , Hsu Chien-Chin , Wang Yi-Fong , Lin Hung-Jung , Wang Jhi-Joung , Guo How-Ran
Published: October 2018

The purpose of this study was to evaluate the effects of hyperbaric oxygen therapy (HBOT) on reducing neurological sequelae (NS) in patients with carbon monoxide poisoning (COP). Using a nationwide database of insurance claims in Taiwan, we conducted a population-based cohort study to identify 24,046 patients with COP diagnosed between 1999 and 2012, including 6793 (28.2%) patients who received HBOT and 17,253 (71.8%) patients who did not. We followed the two cohorts of patients and compared the occurrence of NS. The two cohorts had similar sex ratios, but patients who received HBOT were younger (34.8 ± 14.8 vs. 36.1 ± 17.2 years, p < 0.001). Patients who received HBOT had a higher risk for NS (adjusted hazard ratio [AHR]: 1.4; 95% confidence interval [CI]: 1.4–1.5), after adjusting for age, sex, underlying comorbidities (hypertension, diabetes, chronic obstructive pulmonary disease, hyperlipidemia, malignancy, coronary artery disease, congestive heart failure, liver disease, renal disease, connective tissue disease, human immunodeficiency virus [HIV] infection, and alcoholism), monthly income, suicide, drug poisoning, and acute respiratory failure. We observed similar findings when we stratified the patients by age, sex, underlying comorbidities, and monthly income. The increased risk was most prominent in the first 2 weeks (AHR: 2.4; 95% CI: 2.1–2.7) and remained significant up to 6 months later (AHR: 1.6; 95% CI: 1.4–1.7). The risk for NS was higher in patients with COP who received HBOT than in those who did not, even after considering the possible impact of longer observation periods on survivors. Further studies that included the potential confounding factors we did not measure are needed to confirm findings in this study.
Toward Variability Characterization and Statistic Models’ Constitution for the Prediction of Exponentially Graded Plates’ Static Response
Authors: Rosa Rafael da Silva Batista , Loja Maria Amélia Ramos , Carvalho Alda Cristina Jesus Valentim Nunes de
Published: October 2018

Functionally graded composite materials may constitute an advantageous alternative to engineering applications, allying a customized tailoring capability to its inherent continuous properties transition. However, these attractive characteristics must account for the uncertainty that affects these materials and their structures’ physical quantities. Therefore, it is important to analyze how this uncertainty will modify the foreseen deterministic response of a structure that is built with these materials, identifying which of the parameters are responsible for a greater impact. To pursue this main objective, the material and geometrical parameters that characterize a plate made of an exponentially graded material are generated according to a random multivariate normal distribution, using the Latin hypercube sampling technique. Then, a set of finite element analyses based on the first-order shear deformation theory are performed to characterize the linear static responses of these plates, which are further correlated to the input parameters. This work also considers the constitution of statistic models in order to allow their use as alternative prediction models. The results show that for the plates that were analyzed, the uncertainty associated with the elasticity modulus of both phases is mainly responsible for the maximum transverse deflection variability. The effectiveness of the statistical models that are built are also shown.
Bibliometric Keyword Analysis across Seventeen Years (2000–2016) of Intelligence Articles
Authors: Pesta Bryan , Fuerst John , Kirkegaard Emil
Published: October 2018

An article’s keywords are distinct because they represent what authors feel are the most important words in their papers. Combined, they can even shed light on which research topics in a field are popular (or less so). Here we conducted bibliometric keyword analyses of articles published in the journal, Intelligence (2000–2016). The article set comprised 916 keyword-containing papers. First, we analyzed frequencies to determine which keywords were most/least popular. Second, we analyzed Web of Science (WOS) citation counts for the articles listing each keyword and we ran regression analyses to examine the effect of keyword categories on citation counts. Third, we looked at how citation counts varied across time. For the frequency analysis, “g factor”, “psychometrics/statistics”, and “education” emerged as the keywords with the highest counts. Conversely, the WOS citation analysis showed that papers with the keywords “spatial ability”, “factor analysis”, and “executive function” had the highest mean citation values. We offer tentative explanations for the discrepant results across frequencies and citations. The analysis across time revealed several keywords that increased (or decreased) in frequency over 17 years. We end by discussing how bibliometric keyword analysis can detect research trends in the field, both now and in the past.
Corrugated Photoactive Thin Films for Flexible Strain Sensor
Authors: Ryu Donghyeon , Mongare Alfred
Published: October 2018

In this study, a flexible strain sensor is devised using corrugated bilayer thin films consisting of poly(3-hexylthiophene) (P3HT) and poly(3,4-ethylenedioxythiophene)-polystyrene(sulfonate) (PEDOT:PSS). In previous studies, the P3HT-based photoactive non-corrugated thin film was shown to generate direct current (DC) under broadband light, and the generated DC voltage varied with applied tensile strain. Yet, the mechanical resiliency and strain sensing range of the P3HT-based thin film strain sensor were limited due to brittle non-corrugated thin film constituents. To address this issue, it is aimed to design a mechanically resilient strain sensor using corrugated thin film constituents. Buckling is induced to form corrugation in the thin films by applying pre-strain to the substrate, where the thin films are deposited, and releasing the pre-strain afterwards. It is known that corrugated thin film constituents exhibit different optical and electronic properties from non-corrugated ones. Therefore, to design the flexible strain sensor, it was studied to understand how the applied pre-strain and thickness of the PEDOT:PSS conductive thin film affects the optical and electrical properties. In addition, strain effect was investigated on the optical and electrical properties of the corrugated thin film constituents. Finally, flexible strain sensors are fabricated by following the design guideline, which is suggested from the studies on the corrugated thin film constituents, and the DC voltage strain sensing capability of the flexible strain sensors was validated. As a result, the flexible strain sensor exhibited a tensile strain sensing range up to 5% at a frequency up to 15 Hz with a maximum gauge factor ~7.
Investigation on an Innovative Method for High-Speed Low-Damage Micro-Cutting of CFRP Composites with Diamond Dicing Blades
Authors: Yuan Zewei , Hu Jintao , Wen Quan , Cheng Kai , Zheng Peng
Published: October 2018

This paper presents an innovative method for high-speed micro-cutting of carbon fiber reinforced plastics (CFRP). It employs a diamond dicing blade for micromachining applications, with a thickness of about 200 μm and rotational speeds up to 30,000 rpm so as to meet the low-damage surface integrity requirements. The process parameters, cutting damage, surface roughness, and the spindle vibration were thoroughly investigated to evaluate and validate the method. The results indicate that a high cutting speed up to 76 m/s not only remarkably increases the rigidity of an ultra-thin dicing blade, but also decreases the cutting depth per diamond grit to below 10 nm, both of which are very conducive to obtaining a very fine machined surface of about Ra 0.025 μm, with no obvious damage, such as delamination, burrs, and fiber pull out. The serious spindle vibration limits the rotational speed to increase further, and the rotational speed of 25,000 rpm achieves the best fine machined surface. Furthermore, unlike most research results of the drilling and milling method, the proposed micro-cutting method obtains the maximum cutting current and surface roughness when cutting at 0° fiber orientation, while obtaining a minimum cutting current and surface roughness when cutting at 90° fiber orientation. The metal-bonded dicing blade achieves smaller surface roughness than the resin-bonded dicing blade. This paper also discusses the cutting mechanism by investigating the morphology of the machined surface and concludes that the micro breakage and plastic-flow in local regions of fibers and resin are the main material removal mechanisms for dicing CFRP composites with a diamond abrasive blade.
The Opening Capability for Security against Privacy Infringements in the Smart Grid Environment
Authors: Eom Sungwook , Huh Jun-Ho
Published: October 2018

It is now known that more information can be leaked into the smart grid environment than into the existing environment. In particular, specific information such as energy consumption data can be exposed via smart devices. Such a phenomenon can incur considerable risks due to the fact that both the amount and the concreteness of information increase when more types of information are combined. As such, this study aimed to develop an anonymous signature technique along with a signature authentication technique to prevent infringements of privacy in the smart grid environment, and they were tested and verified at the testbed used in a previous study. To reinforce the security of the smart grid, a password and anonymous authentication algorithm which can be applied not only to extendable test sites but also to power plants, including nuclear power stations, was developed. The group signature scheme is an anonymous signature schemes where the authenticator verifies the group signature to determine whether the signer is a member of a certain group but he/she would not know which member actually signed in. However, in this scheme, the identity of the signer can be revealed through an “opener” in special circumstances involving accidents, incidents, or disputes. Since the opener can always identify the signer without his/her consent in such cases, the signer would be concerned about letting the opener find out his/her anonymous activities. Thus, an anonymous signature scheme where the signer issues a token when entering his/her signature to allow the opener to confirm his/her identity only from that token is proposed in this study.
Surrogate-Based Optimization Using an Open-Source Framework: The Bulbous Bow Shape Optimization Case
Authors: Guerrero Joel , Cominetti Alberto , Pralits Jan , Villa Diego
Published: October 2018

Shape optimization is a very time-consuming and expensive task, especially if experimental tests need to be performed. To overcome the challenges of geometry optimization, the industry is increasingly relying on numerical simulations. These kinds of problems typically involve the interaction of three main applications: a solid modeler, a multi-physics solver, and an optimizer. In this manuscript, we present a shape optimization work-flow entirely based on open-source tools; it is fault tolerant and software agnostic, allows for asynchronous simulations, and has a high degree of automation. To demonstrate the usability and flexibility of the proposed methodology, we tested it in a practical case related to the naval industry, where we aimed at optimizing the shape of a bulbous bow in order to minimize the hydrodynamic resistance. As design variables, we considered the protrusion and immersion of the bulbous bow, and we used surrogate-based optimization. From the results presented, a non-negligible resistance reduction is obtainable using the proposed work-flow and optimization strategy.
Anticancer Activity of Fascaplysin against Lung Cancer Cell and Small Cell Lung Cancer Circulating Tumor Cell Lines
Authors: Rath Barbara , Hochmair Maximilian , Plangger Adelina , Hamilton Gerhard
Published: October 2018

Lung cancer is a leading cause of tumor-associated mortality. Fascaplysin, a bis-indole of a marine sponge, exhibit broad anticancer activity as specific CDK4 inhibitor among several other mechanisms, and is investigated as a drug to overcome chemoresistance after the failure of targeted agents or immunotherapy. The cytotoxic activity of fascaplysin was studied using lung cancer cell lines, primary Non-Small Cell Lung Cancer (NSCLC) and Small Cell Lung Cancer (SCLC) cells, as well as SCLC circulating tumor cell lines (CTCs). This compound exhibited high activity against SCLC cell lines (mean IC50 0.89 µM), as well as SCLC CTCs as single cells and in the form of tumorospheres (mean IC50 0.57 µM). NSCLC lines showed a mean IC50 of 1.15 µM for fascaplysin. Analysis of signal transduction mediators point to an ATM-triggered signaling cascade provoked by drug-induced DNA damage. Fascaplysin reveals at least an additive cytotoxic effect with cisplatin, which is the mainstay of lung cancer chemotherapy. In conclusion, fascaplysin shows high activity against lung cancer cell lines and spheroids of SCLC CTCs which are linked to the dismal prognosis of this tumor type. Derivatives of fascaplysin may constitute valuable new agents for the treatment of lung cancer.
Lower Airway Virology in Health and Disease—From Invaders to Symbionts
Authors: Jankauskaitė Lina , Misevičienė Valdonė , Vaidelienė Laimutė , Kėvalas Rimantas
Published: October 2018

Studies of human airway virome are relatively recent and still very limited. Culture-independent microbial techniques showed growing evidence of numerous viral communities in the respiratory microbial ecosystem. The significance of different acute respiratory viruses is already known in the pathogenesis of chronic conditions, such as asthma, cystic fibrosis (CF), or chronic obstructive lung disease (COPD), and their exacerbations. Viral pathogens, such as influenza, metapneumovirus, parainfluenza, respiratory syncytial virus, or rhinovirus, have been associated with impaired immune response, acute exacerbations, and decrease in lung function in chronic lung diseases. However, more data have attributed a role to Herpes family viruses or the newly identified Anelloviridae family of viruses in chronic diseases, such as asthma, idiopathic pulmonary fibrosis (IPF), or CF. Impaired antiviral immunity, bacterial colonization, or used medication, such as glucocorticoids or antibiotics, contribute to the imbalance of airway microbiome and may shape the local viral ecosystem. A specific part of virome, bacteriophages, frames lung microbial communities through direct contact with its host, the specific bacteria known as Pseudomonas aeruginosa or their biofilm formation. Moreover, antibiotic resistance is induced through phages via horizontal transfer and leads to more severe exacerbations of chronic airway conditions. Morbidity and mortality of asthma, COPD, CF, and IPF remains high, despite an increased understanding and knowledge about the impact of respiratory virome in the pathogenesis of these conditions. Thus, more studies focus on new prophylactic methods or therapeutic agents directed toward viral–host interaction, microbial metabolic function, or lung microbial composition rearrangement.
Citrus limon Extract Loaded in Vesicular Systems for the Protection of Oral Cavity
Authors: Manconi Maria , Manca Maria Letizia , Caddeo Carla , Sarais Giorgia , Palmieri Alessandra , D’Hallewin Guy , Fadda Anna Maria
Published: October 2018

Background: The nanoincorporation of the extract of Citrus limon (L.) Osbeck var. pompia into liposomes was aimed at improving its antioxidant and antibacterial effects. Methods: The extract of the rind of Citrus limon (L.) Osbeck var. pompia was obtained by maceration in ethanol, evaporation, and freeze-drying. The extract phytochemical fingerprint was obtained by HPLC and mass spectrometry, and it was determined that gallic acid, neohesperidin, eriocitrin, and neoeriocitrin were the most abundant components. The freeze-dried extract was loaded in liposomes, glycerosomes, and penetration-enhancer-containing vesicles prepared with propylene glycol (PG-PEVs). Results: Capability of the vesicles of improving efficacy of the extract in counteracting oxidative stress was studied in vitro in keratinocytes, along with antimicrobial activity against planktonic cultures of Streptococcus mutans, Lactobacillus acidophilus, and Streptococcus sanguinis. Conclusion: Results showed that the vesicles, especially glycerosomes and PG-PEVs, prevented oxidative damage and cell death, and inhibited bacterial proliferation.
Atypical Antipsychotics and the Human Skeletal Muscle Lipidome
Authors: Burghardt Kyle J. , Ward Kristen M. , Sanders Elani J. , Howlett Bradley H. , Seyoum Berhane , Yi Zhengping
Published: October 2018

Atypical antipsychotics (AAPs) are a class of medications associated with significant metabolic side effects, including insulin resistance. The aim of this study was to analyze the skeletal muscle lipidome of patients on AAPs, compared to mood stabilizers, to further understand the molecular changes underlying AAP treatment and side effects. Bipolar patients on AAPs or mood stabilizers underwent a fasting muscle biopsy and assessment of insulin sensitivity. A lipidomic analysis of total fatty acids (TFAs), phosphatidylcholines (PCs) and ceramides (CERs) was performed on the muscle biopsies, then lipid species were compared between treatment groups, and correlation analyses were performed with insulin sensitivity. TFAs and PCs were decreased and CERs were increased in the AAP group relative to those in the mood stabilizer group (FDR q-value <0.05). A larger number of TFAs and PCs were positively correlated with insulin sensitivity in the AAP group compared to those in the mood stabilizer group. In contrast, a larger number of CERs were negatively correlated with insulin sensitivity in the AAP group compared to that in the mood stabilizer group. The findings here suggest that AAPs are associated with changes in the lipid profiles of human skeletal muscle when compared to mood stabilizers and that these changes correlate with insulin sensitivity.
Rapid Prototyping of Polymer-Based Rolled-Up Microfluidic Devices
Authors: Arayanarakool Rerngchai , See Hian , Marshall Samuel , Virik Niven , Wang Heng , Lee Poh , Chen Peter
Published: October 2018

This work presents the simple and rapid fabrication of a polymer-based microfluidic prototype manufactured by rolling up thin films of polymer. The thin films were fabricated via a casting method and rolled up around a center core with the aid of plasma activation to create a three-dimensional (3D) spiral microchannel, hence reducing the time and cost of manufacture. In this work, rolled-up devices with single or dual fluidic networks fabricated from a single or two films were demonstrated for heat sink or heat exchanger applications, respectively. The experimental results show good heat transfer in the rolled-up system at various flow rates for both heat sink and heat exchanger devices, without any leakages. The rolled-up microfluidic system creates multiple curved channels, allowing for the generation of Dean vortices, which in turn lead to an enhancement of heat and mass transfer and prevention of fouling formation. These benefits enable the devices to be employed for many diverse applications, such as heat-transfer devices, micromixers, and sorters. To our knowledge, this work would be the first report on a microfluidic prototype of 3D spiral microchannel made from rolled-up polymeric thin film. This novel fabrication approach may represent the first step towards the development of a pioneering prototype for roll-to-roll processing, permitting the mass production of polymer-based microchannels from single or multiple thin films.
Application of Depletion Attraction in Mineral Flotation: I. Theory
Authors: Choi Junhyun , Kim Gahee , Choi Sowon , Kim KyuHan , Han Yosep , Bradford Scott , Choi Siyoung , Kim Hyunjung
Published: October 2018

We investigate the role of depletion interactions in the particle–bubble interactions that determine the attachment capability of particles on the bubble surface in flotation. In this article, we propose a theoretical model that explains how this attractive interaction could enhance flotation efficiency. Two optimum conditions are determined for the concentration and molecular weight of the depletion agent. The optimum concentration can be determined through the extent of surface activity of the depletion agents. The magnitude of the depletion attraction increases as the concentration increases; however, an increase in the concentration simultaneously enhances its surface concentration. The bubble surface adsorption of the depletion agent results in polymer brushes on the bubble surface that produce a large repulsive interaction. In contrast, the optimal molecular weight of the depletion agents is given by the interaction between the depletion agent sizes, which is determined by its molecular weight and Debye length which is determined by the solution ionic strength. We demonstrate that exploiting this depletion interaction could significantly enhance the flotation efficiency and in principal could be used for any particle system.
Nanoemulsion-Enabled Oral Delivery of Novel Anticancer ω-3 Fatty Acid Derivatives
Authors: Garrastazu Pereira Gabriela , Rawling Tristan , Pozzoli Michele , Pazderka Curtis , Chen Yongjuan , Dunstan Colin R. , Murray Michael , Sonvico Fabio
Published: October 2018

Lipid-based drugs are emerging as an interesting class of novel anticancer drugs with the potential to target specific cancer cell metabolic pathways linked to their proliferation and invasiveness. In particular, ω-3 polyunsaturated fatty acids (PUFA) derivatives such as epoxides and their bioisosteres have demonstrated the potential to suppress growth and promote apoptosis in triple-negative human breast cancer cells MDA-MB-231. In this study, 16-(4′-chloro-3′-trifluorophenyl)carbamoylamino]hexadecanoic acid (ClFPh-CHA), an anticancer lipid derived from ω-3,17,18-epoxyeicosanoic acid, was formulated as a stable nanoemulsion with size around 150 nm and narrow droplet size distribution (PDI < 0.200) through phase-inversion emulsification process followed by high pressure homogenization in view of an oral administration. The ClFPh-CHA-loaded nanoemulsions were able to significantly decrease the relative tumor volume in mice bearing an intramammary tumor xenograft at all doses tested (2.5, 10 and 40 mg/kg) after 32 days of daily oral administration. Furthermore, absolute tumor weight was decreased to 50% of untreated control at 10 and 40 mg/kg, while intraperitoneal administration could achieve a significant reduction only at the highest dose of 40 mg/kg. Results suggest that oral administration of ClFPh-CHA formulated as a nanoemulsion has a sufficient bioavailability to provide an anticancer effect in mice and that the activity is at least equal if not superior to that obtained by a conventional parenteral administration of equivalent doses of the same drug.
Frequency-Reconfigurable Wide-Angle Terahertz Absorbers Using Single- and Double-Layer Decussate Graphene Ribbon Arrays
Authors: Ye Longfang , Zeng Fang , Zhang Yong , Xu Xiong , Yang Xiaofan , Liu Qing Huo
Published: October 2018

We propose and numerically demonstrate two novel terahertz absorbers made up of periodic single- and double-layer decussate graphene ribbon arrays. The simulated results show that the proposed absorbers have narrowband near-unity terahertz absorption with ultra-wide frequency reconfiguration and angular stability. By tuning the Fermi level of graphene ribbons, the over 90% absorbance peak frequency of the absorber with single-layer graphene structure can be flexibly adjusted from 6.85 to 9.85 THz for both the transverse magnetic (TM) and transverse electric (TE) polarizations. This absorber with single-layer graphene demonstrates excellent angular stability with the absorbance peaks of the reconfigurable absorption bands remaining over 99.8% in a wide angle of incidence ranging from 0 to 70°. The tuning frequency can be significantly enhanced by using the absorber with double-layer graphene structure from 5.50 to 11.28 THz and 5.62 to 10.65 THz, approaching two octaves under TM and TE polarizations, respectively. The absorbance peaks of the reconfigurable absorption band of this absorber for both polarizations maintain over 70%, even at a large angle of incidence up to 70°. Furthermore, an analytical fitting model is also proposed to accurately predict the absorbance peak frequencies for this variety of absorbers. Benefitting from these attractive properties, the proposed absorber may have great potential applications in tunable terahertz trapping, detecting, sensing, and various terahertz optoelectronic devices.
Effect of Fermentation with Different Lactic Acid Bacteria Starter Cultures on Biogenic Amine Content and Ripening Patterns in Dry Fermented Sausages
Authors: Pasini Federica , Soglia Francesca , Petracci Massimiliano , Caboni Maria Fiorenza , Marziali Sara , Montanari Chiara , Gardini Fausto , Grazia Luigi , Tabanelli Giulia
Published: October 2018

In the present study, two different diameter (small and large) Milano-type dry fermented sausages were industrially produced to evaluate the effect of two different LAB starter cultures (Lactobacillus sakei and Pediococcus pentosaceus) on biogenic amines (BAs) content, proteolysis, and lipolysis taking place during both fermentation and ripening. With regard to BAs, putrescine and tyramine were mostly found in fermented sausages having large diameter and those inoculated with P. pentosaceus/S. xylosus exhibited significantly higher accumulation of these compounds. Overall, the small size sausages showed a more pronounced proteolysis taking place during processing. In addition, aside from the distinctive electrophoretic bands detected with both starter cultures, a more pronounced proteolysis and a faster protein hydrolysis was observed in salami inoculated with P. pentosaceus/S. xylosus. As for lipolysis, a significantly higher amount of diacylglycerols was observed at the end of ripening in the sausages inoculated with L. sakei/S. xylosus, which concurrently exhibited an increased D32, D34, and D36 series. The results of the present study confirms profound differences in BAs concentration, proteolysis, and lipolysis. These findings are strictly dependent on the starter cultures, which demonstrates that the choice of an appropriate starter optimized for peculiar products and processes should be the key factor to improve safety and quality features of traditional fermented sausages.
Improved Diet Quality and Nutrient Adequacy in Children and Adolescents with Abdominal Obesity after a Lifestyle Intervention
Authors: Ojeda-Rodríguez Ana , Zazpe Itziar , Morell-Azanza Lydia , Chueca María J. , Azcona-sanjulian Maria Cristina , Marti Amelia
Published: October 2018

High rates of childhood obesity require integral treatment with lifestyle modifications that achieve weight loss. We evaluated a lifestyle intervention on nutrient adequacy and diet quality in children and adolescents with abdominal obesity. A randomized controlled trial was performed on 107 participants, assigned either to a usual care group or to an intensive care group that followed a moderate hypocaloric Mediterranean diet and received nutritional education. Intake adequacy was evaluated using Dietary Reference Intakes and diet quality through the Diet Quality Index for Adolescents (DQI-A), the Healthy Lifestyle Diet-Index (HLD-I) and the Mediterranean Diet Quality Index (KIDMED). Both groups achieved a significant reduction in BMI standard deviation score (BMI-SDS), glucose and total cholesterol levels. Intake of Calcium, Iodine and vitamin D were higher in the intensive care group, with enhanced compliance with recommendations. Higher dietary scores were associated with lower micronutrient inadequacy. DQI-A and HLD-I were significantly higher in the intensive care group vs. usual care group after the treatment. In conclusion, we observed that an intensive lifestyle intervention was able to reduce BMI-SDS in children with abdominal obesity. Furthermore, participants significantly improved dietary indices getting closer to the nutritional recommendations. Therefore, these diet quality indices could be a valid indicator to evaluate micronutrient adequacy.
Morphologies Tuning of Polypyrrole and Thermoelectric Properties of Polypyrrole Nanowire/Graphene Composites
Authors: Du Yong , Niu Hao , Li Jun , Dou Yunchen , Shen Shirley Z. , Jia Runping , Xu Jiayue
Published: October 2018

Polypyrrole (PPy) with different morphologies (e.g., particles, nanotubes, and nanowires) were successfully prepared by adding or without adding different kinds of surfactants through a chemical oxidative polymerization method, respectively. The results show that the morphologies of PPy can be effectively controlled and have a significantly effects on their thermoelectric properties. The PPy nanowires exhibit the highest electrical conductivity and Seebeck coefficient among the various PPy morphologies, such as particles, nanotubes, and nanowires, so PPy nanowires were chosen to prepare PPy nanowire/graphene thermoelectric composites via a soft template polymerization method using cetyltrimethyl ammonium bromide as the template. Both electrical conductivity and Seebeck coefficient of the PPy nanowire/graphene composites increased as the content of graphene increases from 0 to 20 wt %, and as the measured temperature increases from 300 K to 380 K, which leds to the same trend for the power factor. A highest power factor of 1.01 μWm−1K−2 at ~380 K was obtained for the PPy nanowire/graphene composites with 20 wt % PPy nanowire, which is about 3.3 times higher than that of the pure PPy nanowire.
Isolation and Characterization of Cellulose Nanocrystals from Rejected Fibers Originated in the Kraft Pulping Process
Authors: Aguayo María Graciela , Fernández Pérez Arturo , Reyes Guillermo , Oviedo Claudia , Gacitúa William , Gonzalez Raúl , Uyarte Omar
Published: October 2018

In the final process of the bleached kraft pulp there are some cellulose fibers that are separated from the main fibers stream; these fibers are rejected and considered as a low quality fibers, these fibers are known as rejected fiber (RF). In the present work the potential use of these fibers for Cellulose Nanocrystals (CNCs) synthesis was studied. The physical and chemical properties of synthesized CNCs were characterized through different techniques such as Atomic Force Microscopy (AFM), Scanning Electron Microscopy (SEM), X-Ray Diffraction (XRD), Fourier-Transform Infrared Spectroscopy (FTIR), and Thermogravimetric Analysis (TGA). Results demonstrate the feasibility of CNCs synthesis with a yield of 28.1% and 36.9%, and crystallinity of 73.5% and 82.7%. Finally, the morphology and synthesis conditions suggest that this industrial reject fiber (RF) could be used as a source for the CNCs production, thus adding value to the kraft process and opening new possibilities for innovation in the pulp industry.
Scattering and Radiative Properties of Morphologically Complex Carbonaceous Aerosols: A Systematic Modeling Study
Authors: Liu Li , Mishchenko Michael I.
Published: October 2018

This paper provides a thorough modeling-based overview of the scattering and radiative properties of a wide variety of morphologically complex carbonaceous aerosols. Using the numerically-exact superposition T-matrix method, we examine the absorption enhancement, absorption Ångström exponent (AAE), backscattering linear depolarization ratio (LDR), and scattering matrix elements of black-carbon aerosols with 11 different model morphologies ranging from bare soot to completely embedded soot–sulfate and soot–brown carbon mixtures. Our size-averaged results show that fluffy soot particles absorb more light than compact bare-soot clusters. For the same amount of absorbing material, the absorption cross section of internally mixed soot can be more than twice that of bare soot. Absorption increases as soot accumulates more coating material and can become saturated. The absorption enhancement is affected by particle size, morphology, wavelength, and the amount of coating. We refute the conventional belief that all carbonaceous aerosols have AAEs close to 1.0. Although LDRs caused by bare soot and certain carbonaceous particles are rather weak, LDRs generated by other soot-containing aerosols can reproduce strong depolarization measured by Burton et al. for aged smoke. We demonstrate that multi-wavelength LDR measurements can be used to identify the presence of morphologically complex carbonaceous particles, although additional observations can be needed for full characterization. Our results show that optical constants of the host/coating material can significantly influence the scattering and absorption properties of soot-containing aerosols to the extent of changing the sign of linear polarization. We conclude that for an accurate estimate of black-carbon radiative forcing, one must take into account the complex morphologies of carbonaceous aerosols in remote sensing studies as well as in atmospheric radiation computations.
Multi-Resolution Feature Fusion for Image Classification of Building Damages with Convolutional Neural Networks
Authors: Duarte Diogo , Nex Francesco , Kerle Norman , Vosselman George
Published: October 2018

Remote sensing images have long been preferred to perform building damage assessments. The recently proposed methods to extract damaged regions from remote sensing imagery rely on convolutional neural networks (CNN). The common approach is to train a CNN independently considering each of the different resolution levels (satellite, aerial, and terrestrial) in a binary classification approach. In this regard, an ever-growing amount of multi-resolution imagery are being collected, but the current approaches use one single resolution as their input. The use of up/down-sampled images for training has been reported as beneficial for the image classification accuracy both in the computer vision and remote sensing domains. However, it is still unclear if such multi-resolution information can also be captured from images with different spatial resolutions such as imagery of the satellite and airborne (from both manned and unmanned platforms) resolutions. In this paper, three multi-resolution CNN feature fusion approaches are proposed and tested against two baseline (mono-resolution) methods to perform the image classification of building damages. Overall, the results show better accuracy and localization capabilities when fusing multi-resolution feature maps, specifically when these feature maps are merged and consider feature information from the intermediate layers of each of the resolution level networks. Nonetheless, these multi-resolution feature fusion approaches behaved differently considering each level of resolution. In the satellite and aerial (unmanned) cases, the improvements in the accuracy reached 2% while the accuracy improvements for the airborne (manned) case was marginal. The results were further confirmed by testing the approach for geographical transferability, in which the improvements between the baseline and multi-resolution experiments were overall maintained.
High-Resolution Seismocardiogram Acquisition and Analysis System
Authors: Leitão Fábio , Moreira Eurico , Alves Filipe , Lourenço Mário , Azevedo Olga , Gaspar João , Rocha Luis A.
Published: October 2018

Several devices and measurement approaches have recently been developed to perform ballistocardiogram (BCG) and seismocardiogram (SCG) measurements. The development of a wireless acquisition system (hardware and software), incorporating a novel high-resolution micro-electro-mechanical system (MEMS) accelerometer for SCG and BCG signals acquisition and data treatment is presented in this paper. A small accelerometer, with a sensitivity of up to 0.164 µs/µg and a noise density below 6.5 µg/ Hz is presented and used in a wireless acquisition system for BCG and SCG measurement applications. The wireless acquisition system also incorporates electrocardiogram (ECG) signals acquisition, and the developed software enables the real-time acquisition and visualization of SCG and ECG signals (sensor positioned on chest). It then calculates metrics related to cardiac performance as well as the correlation of data from previously performed sessions with echocardiogram (ECHO) parameters. A preliminarily clinical study of over 22 subjects (including healthy subjects and cardiovascular patients) was performed to test the capability of the developed system. Data correlation between this measurement system and echocardiogram exams is also performed. The high resolution of the MEMS accelerometer used provides a better signal for SCG wave recognition, enabling a more consistent study of the diagnostic capability of this technique in clinical analysis.
Adaptive Single Photon Compressed Imaging Based on Constructing a Smart Threshold Matrix
Authors: Shangguan Wentao , Yan Qiurong , Wang Hui , Yuan Chenglong , Li Bing , Wang Yuhao
Published: October 2018

We demonstrate a single-photon compressed imaging system based on single photon counting technology and compressed sensing theory. In order to cut down the measurement times and shorten the imaging time, a fast and efficient adaptive sampling method, suited for single-photon compressed imaging, is proposed. First, the pre-measured rough images are transformed into sparse bases as a priori information. Then a smart threshold matrix is designed by using large sparse coefficients of the rough image in sparse bases. The adaptive measurement matrix is obtained by modifying the original Gaussian random matrix with the specially designed threshold matrix. Building the adaptive measurement matrix requires only one level of sparse representation, which means that adaptive imaging can be achieved quickly with very little computation. The experimental results show that the reconstruction effect of the image measured using the adaptive measurement matrix is obviously superior than that of the Gaussian random matrix under different measurement times and different reconstruction algorithms.
An Incentive Mechanism in Mobile Crowdsourcing Based on Multi-Attribute Reverse Auctions
Authors: Hu Ying , Wang Yingjie , Li Yingshu , Tong Xiangrong
Published: October 2018

In order to avoid malicious competition and select high quality crowd workers to improve the utility of crowdsourcing system, this paper proposes an incentive mechanism based on the combination of reverse auction and multi-attribute auction in mobile crowdsourcing. The proposed online incentive mechanism includes two algorithms. One is the crowd worker selection algorithm based on multi-attribute reverse auction that adopts dynamic threshold to make an online decision for whether accept a crowd worker according to its attributes. Another is the payment determination algorithm which determines payment for a crowd worker based on its reputation and quality of sensing data, that is, a crowd worker can get payment equal to the bidding price before performing task only if his reputation reaches good reputation threshold, otherwise he will get payment based on his data sensing quality. We prove that our proposed online incentive mechanism has the properties of computational efficiency, individual rationality, budget-balance, truthfulness and honesty. Through simulations, the efficiency of our proposed online incentive mechanism is verified which can improve the efficiency, adaptability and trust degree of the mobile crowdsourcing system.
Pulse Oximetry with Two Infrared Wavelengths without Calibration in Extracted Arterial Blood
Authors: Yossef Hay Ohad , Cohen Meir , Nitzan Itamar , Kasirer Yair , Shahroor-karni Sarit , Yitzhaky Yitzhak , Engelberg Shlomo , Nitzan Meir
Published: October 2018

Oxygen saturation in arterial blood (SaO2) provides information about the performance of the respiratory system. Non-invasive measurement of SaO2 by commercial pulse oximeters (SpO2) make use of photoplethysmographic pulses in the red and infrared regions and utilizes the different spectra of light absorption by oxygenated and de-oxygenated hemoglobin. Because light scattering and optical path-lengths differ between the two wavelengths, commercial pulse oximeters require empirical calibration which is based on SaO2 measurement in extracted arterial blood. They are still prone to error, because the path-lengths difference between the two wavelengths varies among different subjects. We have developed modified pulse oximetry, which makes use of two nearby infrared wavelengths that have relatively similar scattering constants and path-lengths and does not require an invasive calibration step. In measurements performed on adults during breath holding, the two-infrared pulse oximeter and a commercial pulse oximeter showed similar changes in SpO2. The two pulse oximeters showed similar accuracy when compared to SaO2 measurement in extracted arterial blood (the gold standard) performed in intensive care units on newborns and children with an arterial line. Errors in SpO2 because of variability in path-lengths difference between the two wavelengths are expected to be smaller in the two-infrared pulse oximeter.
Examining the Conflicting Relationship between U.S. National Parks and Host Communities: Understanding a Community’s Diverging Perspectives
Authors: Lee Jae Ho , Matarrita-Cascante David , Xu Ying , Schuett Michael
Published: October 2018

The growing importance of participatory and collaborative approaches in resource management has resulted in an increased emphasis on identifying the complex relationships between natural national parks and neighboring rural communities. Given the limited number of studies dealing with parks beyond rural areas, our exploratory case study examines how conflict stemming from diverse community stakeholders’ perspectives and values in regard to the San Antonio Missions National Historical Park influences their involvement and attitudes toward park management. Thirty-two interviews were conducted and analyzed using a content-analysis methodology. Guided by the Progress Triangle conflict management framework, each stakeholder’s views, interests, and aspirations associated with the missions were organized according to the framework’s three dimensions: Substance, procedure, and relationship. The study findings discussed how stakeholders’ varying perspectives regarding cultural resources influenced their interactions with urban historical national parks and their attitudes toward park management. Furthermore, how stakeholders can reconcile their differences through a collaborative approach for better park management was discussed.
Spatial Diffusion of Taiwanese Enterprises in Mainland China under the Vision of Rural Industrial Vitalization
Authors: Lin Mingshui , Lin Juan , Lin Caibin , Zhang An , Wang Kaiyong
Published: October 2018

The Taiwanese, who have accumulated rich experience from the strategy, have greatly promoted the development of the rural economy in mainland China through the establishment of rural Taiwanese enterprises. In the process of the strategy of rural revitalization, it is important to draw on the experience from Taiwan, and to acknowledge the leading role of Taiwanese entrepreneurs. In this study, we considered 941 rural Taiwanese enterprises that were registered in townships and villages in mainland China. Based on the cultural diffusion model, spatial analysis of GIS, and statistical methods, this study analyzed the spatial pattern and evolution of rural Taiwanese enterprises, and predicted the spatial diffusion pattern as well. The study found the following: (1) The reform and opening-up policy leads to the core position of Dongguan and Kunshan, and continues to consolidate the dual-core pattern with a noticeable combined effect. (2) Rural Taiwanese enterprises are mainly engaged in the secondary industry, with characteristics of small-scale and strong independence. They tend to be located in secondary cities in developed regions, in order to reduce costs and obtain maximum profits. (3) They display a V-shaped pattern covering the Eastern coastal line and Hunan-Sichuan line, with Guangdong as the node. (4) It is predicted that, in the next decade, the growth of the enterprises will slow down and their spatial diffusion pattern will be more conspicuous. While the spatial diffusion of Taiwanese enterprises slows down, more domestic investment may lead to industry vitalization in rural China.