bluuebunny/crossref_metadata_2025 huggingface dataset:
Cytotoxicity and Multi-Enzyme Inhibition of Nepenthes miranda Stem Extract on H838 Human Non-Small Cell Lung Cancer Cells and RPA32, Elastase, Tyrosinase, and Hyaluronidase Proteins
Authors: Lee Ching-Yi , Chen Yu-Cheng , Huang Yen-Hua , Lien Yi , Huang Cheng-Yang
Published: March 2024

The carnivorous pitcher plants of the genus Nepenthes have long been known for their ethnobotanical applications. In this study, we prepared various extracts from the pitcher, stem, and leaf of Nepenthes miranda using 100% ethanol and assessed their inhibitory effects on key enzymes related to skin aging, including elastase, tyrosinase, and hyaluronidase. The cytotoxicity of the stem extract of N. miranda on H838 human lung carcinoma cells were also characterized by effects on cell survival, migration, proliferation, apoptosis induction, and DNA damage. The cytotoxic efficacy of the extract was enhanced when combined with the chemotherapeutic agent 5-fluorouracil (5-FU), indicating a synergistic effect. Flow cytometry analysis suggested that the stem extract might suppress H838 cell proliferation by inducing G2 cell cycle arrest, thereby inhibiting carcinoma cell proliferation. Gas chromatography–mass spectrometry (GC–MS) enabled the tentative identification of the 15 most abundant compounds in the stem extract of N. miranda. Notably, the extract showed a potent inhibition of the human RPA32 protein (huRPA32), critical for DNA replication, suggesting a novel mechanism for its anticancer action. Molecular docking studies further substantiated the interaction between the extract and huRPA32, highlighting bioactive compounds, especially the two most abundant constituents, stigmast-5-en-3-ol and plumbagin, as potential inhibitors of huRPA32’s DNA-binding activity, offering promising avenues for cancer therapy. Overall, our findings position the stem extract of N. miranda as a promising source of natural compounds for anticancer therapeutics and anti-skin-aging treatments, warranting further investigation into its molecular mechanisms and potential clinical applications.
Impacts of Climate Change on the Biogeography and Ecological Structure of Zelkova schneideriana Hand.-Mazz. in China
Authors: Wang Chen , Zhang Yuanlan , Sheng Qianqian , Zhu Zunling
Published: March 2024

This study utilized the platform for ensemble forecasting of species distributions, biomod2, to predict and quantitatively analyze the distribution changes of Zelkova schneideriana Hand.-Mazz. under different climate scenarios (SSP1-2.6 and SSP5-8.5) based on climate and land-use data. This study evaluated the geographic range changes in future distribution areas and the results indicated that, under both SSP1-2.6 and SSP5-8.5 scenarios, the distribution area of Zelkova schneideriana would be reduced, showing a trend towards migration to higher latitudes and elevations. Particularly, in the more extreme SSP5-8.5 scenario, the contraction of the distribution area was more pronounced, accompanied by more significant migration characteristics. Furthermore, the ecological structure within the distribution area of Zelkova schneideriana also experienced significant changes, with an increasing degree of fragmentation. The variables of Bio6 (minimum temperature of the coldest month), Bio2 (mean diurnal temperature range), Bio15 (precipitation seasonality), and elevation exhibited important influences on the distribution of Zelkova schneideriana, with temperature being particularly significant. Changes in land use, especially the conversion of cropland, had a significant impact on the species’ habitat. These research findings highlight the distributional pressures faced by Zelkova schneideriana in the future, emphasizing the crucial need for targeted conservation measures to protect this species and similar organisms.
Evaluating the Effects of Feeding a Concentrated Saccharomyces cerevisiae Fermentation Product on the Performance and Stress Susceptibility of Broiler Chickens
Authors: Heinsohn Zachary , Brown Austin , Sobotik Eric , House Gabrielle , Stiewert Austin , Chaney William Evan , Kuttappan Vivek , Archer Gregory S.
Published: March 2024

This study evaluated the effect of a concentrated yeast fermentation product on the performance and stress response of broiler chickens. Day-old Cobb 500 male broiler chicks were randomly allocated to one of two dietary treatments: Control (CON) or concentrated yeast fermentation product (CSCFP, 0.625 kg/MT). On d18, simultaneous feed withdrawal and heat stress challenges were performed for 12 h. Blood was analyzed for plasma corticosterone (CORT) and heterophil-to-lymphocyte ratio (HL) on d19 and d42. Performance parameters were collected throughout the trial: body weight (BW), feed consumption (FC), and feed conversion ratio (FCR). On d19, the CSCFP birds had lower (p ≤ 0.05) CORT (5320.3 ng/mL) and HL (0.14) than the CON birds (9049.6 ng/mL and 0.21). On d42, the CSCFP birds had lower (p ≤ 0.05) CORT (1623.8 ng/mL) and HL (0.74) than the CON birds (2920.2 ng/mL and 1.05). No differences were observed in mortality (p > 0.05). The CON birds had a higher (p ≤ 0.05) FCR than CSCFP throughout all phases. The CON birds consumed more feed than the CSCFP birds throughout all phases (p ≤ 0.05). In conclusion, CYFP reduced stress and improved feed conversion when compared to CON, making it a viable feed additive to improve welfare and production.
Evaluation of the Potential for CO2 Storage and Saline Water Displacement in Huaiyin Sag, Subei Basin, East China
Authors: Zhang Chenglong , Diao Yujie , Fu Lei , Ma Xin , Wang Siyuan , Liu Ting
Published: March 2024

CO2 geological storage combined with deep saline water recovery technology (CO2-EWR) is one of the most effective ways to reduce carbon emissions. Due to the complex structural features, it is difficult to use CO2-EWR technology in Huaiyin Sag, Subei basin, East China. In this study, the multi-source information superposition evaluation technology of GIS was utilized for the selection of CO2 storage sites and water displacement potential target areas in this area, which mainly focused on the sandstone reservoirs of Cretaceous Pukou Formation. Based on the results, a three-dimensional injection–extraction model was established. Various scenarios with different production/injection well ratios (PIR) were simulated. Research has shown that the suitability of the surrounding site of Huaiyin Power Plant can be divided into two levels: relatively suitable and generally suitable; the area in the generally suitable level accounts for more than 80%. At a PIR of 1, CO2 is distributed asymmetrically, whereas at PIRs of 2 or 4, CO2 is distributed symmetrically. When the number of production wells is constant, a higher injection rate results in a faster expansion rate of the CO2 plume. This means that the time taken for the CO2 plume to reach the production wells is shorter. Reservoir pressure increases rapidly after more than 60 years of CO2 injection at lower PIR values, while at higher PIRs, reservoir pressure eventually stabilizes. Higher PIR values correspond to higher gas saturation, indicating a greater capacity for CO2 sequestration with more producing wells. When PIR = 4, the total CO2 injection increased by 55.73% compared to PIR = 1. However, the extraction of saline decreases with an increase in the number of producing wells, resulting in a decrease in replacement efficiency. This study provides a theoretical basis and technical support for the implementation of large-scale CO2-EWR engineering and technology demonstration in this region.
An Experimental Study on Nodular Iron Machined Surfaces Utilizing a Capable 2D Finite Element Model for Precise Surface Roughness Estimation
Authors: Teke Ibrahim T. , Ertas Ahmet H.
Published: March 2024

Nodular iron plays a crucial role in various industries, especially in large-scale applications such as gearboxes. Ensuring that nodular iron remains free from oil leakage and that contact surfaces are properly aligned is essential, given its operational requirements. Achieving flat contact faces through precise machining is therefore of utmost importance. As surface roughness and flatness are closely linked, it is vital to investigate the machining process parameters involved. This study focuses on addressing surface quality issues with EN-GJS-600-3 cast iron by optimizing machining parameters. CMM measurements were utilized to analyze the relationship between surface roughness and flatness, with a surface profile used to assess flatness. Furthermore, a new 2D surface roughness estimation method (2D-SRET) was created and tested with experimental data in order to improve the precision of assessing the discrete flat surface machining procedure.
A Deep Learning Approach to Merge Rule-Based and Human-Operated Camera Control for Teleoperated Robotic Systems
Authors: Jawad Luay , Singh-Chudda Arshdeep , Shankar Abhishek , Pandya Abhilash
Published: March 2024

Controlling a laparoscopic camera during robotic surgery represents a multifaceted challenge, demanding considerable physical and cognitive exertion from operators. While manual control presents the advantage of enabling optimal viewing angles, it is offset by its taxing nature. In contrast, current autonomous camera systems offer predictability in tool tracking but are often rigid, lacking the adaptability of human operators. This research investigates the potential of two distinct network architectures: a dense neural network (DNN) and a recurrent network (RNN), both trained using a diverse dataset comprising autonomous and human-driven camera movements. A comparative assessment of network-controlled, autonomous, and human-operated camera systems is conducted to gauge network efficacies. While the dense neural network exhibits proficiency in basic tool tracking, it grapples with inherent architectural limitations that hinder its ability to master the camera’s zoom functionality. In stark contrast, the recurrent network excels, demonstrating a capacity to sufficiently replicate the behaviors exhibited by a mixture of both autonomous and human-operated methods. In total, 96.8% of the dense network predictions had up to a one-centimeter error when compared to the test datasets, while the recurrent network achieved a 100% sub-millimeter testing error. This paper trains and evaluates neural networks on autonomous and human behavior data for camera control.
Effective Feature Engineering Framework for Securing MQTT Protocol in IoT Environments
Authors: Al Hanif Abdulelah , Ilyas Mohammad
Published: March 2024

The explosive growth of the domain of the Internet of things (IoT) network devices has resulted in unparalleled ease of productivity, convenience, and automation, with Message Queuing Telemetry Transport (MQTT) protocol being widely recognized as an essential communication standard in IoT environments. MQTT enables fast and lightweight communication between IoT devices to facilitate data exchange, but this flexibility also exposes MQTT to significant security vulnerabilities and challenges that demand highly robust security. This paper aims to enhance the detection efficiency of an MQTT traffic intrusion detection system (IDS). Our proposed approach includes the development of a binary balanced MQTT dataset with an effective feature engineering and machine learning framework to enhance the security of MQTT traffic. Our feature selection analysis and comparison demonstrates that selecting a 10-feature model provides the highest effectiveness, as it shows significant advantages in terms of constant accuracy and superior training and testing times across all models. The results of this study show that the framework has the capability to enhance the efficiency of an IDS for MQTT traffic, with more than 96% accuracy, precision, recall, F1-score, and ROC, and it outperformed the most recent study that used the same dataset.
Potential Way to Develop Dengue Virus Detection in Aedes Larvae as an Alternative for Dengue Active Surveillance: A Literature Review
Authors: Rachmawati Yenny , Ekawardhani Savira , Fauziah Nisa , Faridah Lia , Watanabe Kozo
Published: March 2024

The burden of dengue has emerged as a serious public health issue due to its impact on morbidity, mortality, and economic burden. Existing surveillance systems are inadequate to provide the necessary data for the prompt and efficient control of dengue. Passive surveillance of dengue cases may lead to underreporting and delayed mitigation responses. Improved dengue control program requires sensitive and proactive methods for early detection of dengue. We collected and reviewed existing research articles worldwide on detecting dengue virus in Aedes species larvae. Searches were conducted in PUBMED and Google Scholar, including all the studies published in English and Bahasa Indonesia. Twenty-nine studies were included in this review in terms of assay used, positivity rate, and dengue serotype detected. The presence of dengue virus in immature mosquitoes was mostly detected using reverse transcription PCR (RT-PCR) in pooled larvae. In one study, dengue virus was detected in larvae from laboratory-infected mosquitoes using enzyme-linked immunosorbent assay (ELISA). The positivity rate of dengue virus detection ranged from 0 to 50% in field-caught larvae. Although various methods can detect the dengue virus, further research encourages the use of low-cost and less laborious methods for active surveillance of dengue in larvae.
MDCK-Adaptive Mutation of A169S Changes Glycosylation Pattern of Hemagglutinin and Enhances MDCK-Based H7N9 Vaccine Virus Production without Loss of Antigenicity and Immunogenicity
Authors: Chen Po-Ling , Weng Tsai-Chuan , Lai Chia-Chun , Tzeng Tsai-Teng , Lin Min-Han , Hu Kai-Chieh , Hu Alan Yung-Chih , Lee Min-Shi , Sung Wang-Chou
Published: March 2024

The adaptation of egg-derived H7N9 candidate vaccine virus (CVV) in the mammalian cell line is an approach to developing a high-growth virus strain for the mass production of vaccine manufacturing. The adaptive mutations that occur in hemagglutinin (HA) are critical to the activity and potency of the vaccine virus. Previously, we identified a new mutation of A169S in the HA protein of an MDCK-adapted H7N9 vaccine virus (A/Anhui/2013, RG268); however, whether and how this mutation affects vaccine potency remain to be investigated. In this study, we serially passaged RG268 in MDCK cells and found that the HA titer and the TCID50 of the passaged virus RG268-M5 were 4-fold (HA units/50 μL) and 3.5-fold (log10 TCID50/mL) higher than those of the original CVV. By inspecting tandem MS spectra, we identified a new glycosylation site at N167 near the receptor binding site of the HA protein of RG268-M5. Flow cytometry results revealed that RG268-M5 could efficiently infect MDCK cells and initiate viral protein replication as well as that of RG268. Though the new glycosylation site is in the antigenic epitope of viral HA protein, the HI assay result indicated that the antigenicity of RG268-M5 was similar to RG268. Additionally, immunizing mice with RG268-M5 mixed aluminum hydroxide could induce potent antibody responses against the homologous and heterologous H7N9 viruses in vitro whereas the titers were comparable with those from the RG268 group. These results provide in-depth structural information regarding the effects of site-specific glycosylation on virus properties, which have implications for novel avian influenza vaccine development.
Design and Implementation of Improved Gate Driver Circuit for Sensorless Permanent Magnet Synchronous Motor Control
Authors: Ferdiansyah Indra , Hanamoto Tsuyoshi
Published: March 2024

Reliable motor control is important for electric vehicle applications. The control process requires accurate measurements of the current and rotor position information to establish correct motor control design, particularly in sensorless permanent magnet synchronous motor control systems. Practical issues regarding the motor control circuit, such as the effects of parasitic element behavior on the switching components in the insulated gate bipolar transistor-driven inverter, were discussed in this study. It analyzed the effects of parasitic elements that can cause the ringing of switching losses and affect the spike of the signal in the motor current, which must be avoided in the implementation of motor control. The gate driver circuit topology was improved to reduce this effect in motor control devices. The proposed gate driver circuit design with the ringing suppression circuit configuration achieved good performance by keeping the signal spike at less than 10% in the motor current. Furthermore, a signal spike or noise was not observed in the estimation results of rotor position when using current information as the parameter control process. Both conditions were verified by experiments on the designed motor control devices. Under these conditions, signal precision can be achieved in motor control.
Research on Vehicle Frame Optimization Methods Based on the Combination of Size Optimization and Topology Optimization
Authors: He Qun , Li Xinning , Mao Wenjie , Yang Xianhai , Wu Hu
Published: March 2024

The efficient development of electric vehicles is essential to drive society towards sustainable development. Designing a lightweight frame is a key strategy to improve the economy and environment, increase energy efficiency, and reduce carbon emissions. Taking an automatic loading and unloading mixer truck as the research object, a force analysis of its frame was conducted under six typical working conditions. A size optimization method based on a hybrid model of the Kriging model and the analytic hierarchy process (AHP) is proposed. An approximate model of the mass and maximum stress of the frame was established using the Kriging model, and the Kriging model was optimized by using the multi-objective genetic optimization algorithm and the AHP method. Meanwhile, topology optimization was introduced to improve the structural performance of the frame and reduce its weight. The optimization results show that the overall weight of the frame is reduced by 11.96% compared to the pre-optimization period, though it still meets the material performance specifications. By comparing the iterative curves of the single Kriging model with those of the AHP model, it can be seen that the initial optimization efficiency of the hybrid model is about twice as much as that of the AHP model, and the final optimization result is improved by about 3.6% compared with the Kriging model. This validates the hybrid model as an effective tool for the multi-objective optimization of electric vehicle frames, providing more efficient and accurate optimization results for frame design.
Indicators of Potential Use of Electric Vehicles in Urban Areas: A Real-Life Survey-Based Study in Hail, Saudi Arabia
Authors: Al-fouzan Abdulmohsen A. , Almasri Radwan A.
Published: March 2024

This study aimed to uncover the attitudes, preferences, and perceptions of Hail residents toward electric vehicles (EVs) by employing a real-life survey-based approach. This paper presents an in-depth analysis of the potential adoption and impact of EVs to clarify the picture of the transition from using traditional vehicles to using EVs in Hail City, Saudi Arabia. Hail is rapidly becoming a more urbanized city; in the past few decades, the city’s area has expanded from 3242 to 17,526 hectares, and its population has increased dramatically from 82,900 in 1984 to 344,111 in present day. As a result, the city is facing increasingly difficult challenges related to rising vehicle emissions and environmental degradation. A survey was conducted among a diverse group of 346 participants. The survey results show an average of 3.15 cars per family, which indicates a strong connection with personal vehicles. The survey provides a comprehensive picture of the respondents’ socioeconomic background, indicating an average household size of 5.8 people and an average monthly income of SR 13,350. The key findings from the survey reveal that approximately 52.3% of the respondents have 3–4 family members, and nearly half of the families own one or two cars. Government employees formed a major proportion of the respondents. The results show a significant inclination toward EVs, with 78.6% of the participants being aware of EV charging stations and 37.9% expressing a positive attitude towards switching to electric vehicles. Despite this, a large majority (88.7%) have never driven an electric car. The respondents’ driving habits are further explored in the survey, which reveals an average of 2.1 h of daily driving. Furthermore, the respondents disclosed an average weekly fuel expenditure of SR 235. The results also highlight that the average weekly cost for fuel varies among the respondents, with most respondents spending no more than SR 300 per week. Additionally, this study examined the daily vehicle mileage, revealing that 37.9% of the respondents have a daily mileage of 51 to 100 km, which impacts the planning of charging station capacities and locations. The findings suggest a growing interest in EVs and highlight the need for strategic infrastructure development to support the anticipated surge in EV adoption.
Numerical Study of Reinforced Aluminum Composites for Steering Knuckles in Last-Mile Electric Vehicles
Authors: Santana Carlos , Reyes-Osorio Luis , Orona-Hinojos Jesus , Huerta Lizbeth , Rios Alfredo , Zambrano-Robledo Patricia
Published: March 2024

The steering knuckle is a critical component of the suspension and steering drive systems of electric vehicles. The electrification of last-mile vehicles presents a challenge in terms of cost, driving range and compensation of battery weight. This work presents a numerical methodology to evaluate 60XX series aluminum metal matrix composites (AMMCs) with reinforcement ceramic particles for steering knuckle components in medium heavy-duty last-mile cargo vehicles. The use of AMMCs provides lightweight knuckles with sufficient strength, stiffness and safety conditions for electrical vehicle cargo configurations. The numerical study includes three aluminum alloys, two AMMC alloys and an Al 6061-T6 alloy as reference materials. The medium-duty heavy vehicle class < 12 t, such as electrical vehicle cargo configurations, is considered for the numerical study (class 1–4). The maximum von Mises stress for class 4 AMMC alloys exceeds 350 MPa, limited by fracture toughness. The weight reduction is about 65% when compared with commercial cast iron. Moreover, Al 6061-T6 alloys exhibit stress values surpassing 300 MPa, constraining their suitability for heavier vehicles. The study proposes assessing the feasibility of implementing AMMC alloys in critical components like steering knuckles and suggests solutions to enhance conventional vehicle suspension systems and overcome associated challenges. It aims to serve as a lightweight design guide, offering insights into stress variations with differing load conditions across various cargo vehicles.
Monitoring Mangrove Forest Degradation in Mangrove Nature Tourism Park Angke Kapuk, North Jakarta, Indonesia Using NDVI
Authors: Nurafifah Suryana Tsaniya , Purnamasari Sherlina , Ewaldo Kevin
Published: March 2024

Mangrove forests in Angke Kapuk, North Jakarta, are integral parts of the coastal ecosystem and play important roles in supporting environmental sustainability. One component of the Angke Kapuk Mangrove Forest is the Mangrove Nature Tourism Park (MNTP), Angke Kapuk, covering an area of 99.82 hectares. This study aims to analyze mangrove forest degradation in Angke Kapuk Nature Reserve using the Normalized Difference Vegetation Index (NDVI, which allows for mapping mangrove vegetation density and monitoring changes in the vegetation density over time. The objective of this study is to determine the degradation of mangrove forests from 2018 to 2023 using the NDVI derived from Landsat 8 and Landsat 9 satellite imagery. The findings of this study showed a change of 13.16 hectares in forested areas between 2018 and 2023, suggesting forest degradation. Accuracy assessment resulted in 80% overall accuracy with a kappa coefficient of 76.2%. Based on the literature, our results are similar to the acceptable level of accuracy, which is considered to be above 80%. Monitoring mangrove forest areas can serve as a preventive measure to address the issue of mangrove forest degradation. These results underscore the necessity of sustainable forestry monitoring efforts in the MNTP area, as it contributes significantly to providing ecosystem services and maintaining environmental sustainability.
L’Antiquité au cinéma
Authors: Aziza Claude
Published: March 2024

Le lecteur trouvera ici le deuxième article d’une série qui se propose de faire l’histoire d’une autre Antiquité, que je nommerais volontiers « imaginaire », voire « fantasmatique » . Depuis quelques décennies, en effet, partout en Europe, mais surtout en France – raison linguistique oblige – on a vu s’opposer – nouvelle querelle des Anciens et des Modernes – deux conceptions de l’étude de l’Antiquité. Fausse querelle bien entendu : rien ne saurait remplacer l’étude sérieuse et approfondie, qui passe par la connaissance de la langue, de la littérature, de l’histoire, de la civilisation des sociétés antiques. Mais à une époque, la nôtre, qui voit – étonnant paradoxe – l’étude du latin et du grec décliner inexorablement, alors que fleurissent les romans historiques, les films à grand spectacle et les bandes dessinées, il est permis de s’interroger sur de nouvelles procédures qui permettront d’allier le sérieux au ludique et de faire un va-et-vient constant entre le rêve et la réalité, pour le plus grand bien de cette dernière. Il est temps de réconcilier les deux Antiquités et de montrer – autant que faire se peut – que la rigueur universitaire n’est pas incompatible avec l’apparente fantaisie du sujet.
Langage et médecine : la fin du Cratyle platonicien
Authors: Saudelli Lucia
Published: March 2024

At the end of the Cratylus, Socrates compares the permanent becoming of reality to the discharges of people who have a cold. Believing that everything changes constantly, and nothing stands still, he says, leads us to think that the things are sick and ends up making us sick. In order to take care of oneself, one should seek to know the real nature of things because their essence, contrary to appearances, never changes. The aim of this article is to explain the meaning of this argument about bodily illness and mental health, and to show the role that it plays in a dialogue dedicated to language. Plato establishes here a link between the flux of things and the flux in words, between the discharges of the body and the rotations of the soul. In doing so, he criticises all pseudo-language experts, including certain doctors who lack of genuine knowledge as well as moral integrity.
Forger un vers nouveau à l’usage des anciens : le vers politique chez Jean Tzetzès
Authors: Kuttner-Homs Stanislas
Published: March 2024

On juge habituellement les commentaires et les scholies des auteurs grecs médiévaux comme des travaux de l’esprit, qui échappent néanmoins à l’esthétique et aux ambitions littéraires. L’érudit byzantin Jean Tzetzès (c. 1110-c. 1175), connu comme scholiaste, n’échappe pas à ce regard sur son oeuvre de commentaire, bien qu’elle soit entièrement en vers. Pourtant, la métrique et la rythmique de la poésie de Tzetzès invitent à lire ses poèmes comme le moyen de rivaliser avec les Antiques et de les surpasser, voire, en poussant le raisonnement jusqu’à son terme extrême, de mettre les Anciens à l’école des Byzantins. Homère, lecteur de Tzetzès ?
Le marché du crédit à Olynthe et le calendrier des chalcidiens de Thrace
Authors: Faguer Julien
Published: March 2024

S’appuyant sur les résultats d’une thèse consacrée au marché de la terre et du crédit à Athènes et dans les Cyclades (ca 400-100 av. J.-C.), la communication étend l’analyse à deux inscriptions d’Olynthe, en Chalcidique, gravées peu avant la destruction de la ville par les troupes de Philippe II en 348 avant notre ère. Alors que plusieurs indices convergent pour établir que les deux documents se rapportent à la même habitation, l’analyse des transactions sous-jacentes — une vente et un prêt hypothécaire — aboutit à revoir la chronologie relative des deux opérations, datées l’une et l’autre par le même éponyme. L’interprétation proposée conduit à introduire trois modifications dans la séquence des mois du calendrier eubéo-chalcidien, en favorisant une solution qui paraît confortée tout autant par les réflexions de D. Knoepfler sur les fêtes eubéennes que par l’apport du registre des ventes de Ténos (IG XII 5, 872) à notre connaissance des transactions immobilières et des calendriers insulaires.
Efficacy and safety of abobotulinum injection in patients with focal dystonia
Authors: Nguyen Duy Duan , Truong Huu Hung , Truong Thi Ai Van , Tran Thi Kim Anh , Nguyen Xuan Nhan , Nguyen Dinh Toan
Published: March 2024

Objectives: To investigate the clinical features of focal dystonia and evaluate the efficacy and safety of Abobotulinum injection on these patients.

Subjects and methods: A prospective cross-sectional descriptive study on 59 patients and 114 injection sessions of focal dystonia at the Functional Exploration Unit, Hue University of Medicine and Pharmacy Hospital from July 2020 to June 2023. We recorded the dystonia severity by corresponding scale and followed up every one month after the injection to document the maximal subjective improvement and side effects of the injection.

Results: The number of patients with hemifacial spasm: blepharospasm: cervical dystonia: limb dystonia: oromandibular dystonia are 17: 12: 20: 8: 2, respectively. Regarding to hemifacial spasm, the primary cause accounted for 82.4%, the average grading scale was 6.1 ± 0.5; the average dose was 80.9 ± 29.9 U Abobotulinum; the proportion of complete and > 50% improvement was 83.9% of injections; the most common adverse effect was facial weakness in 47.0% of patients and 41.9% of injections. In terms of blepharospasm, the mean severity was 5.5 ± 0.9 on the Jankovic’s scale; the average therapeutic dose of 68.1 ± 27.6 helped 90.5% improve > 50% and completely; 1/3 of patients had lagophthalmos, only 2 patient had bruising but no one had ptosis. Cervical dystonia patients had mean Toronto Western Spasmodic Torticollis Rating Scale of 26.3 ± 9.6; using an average dose of 406.1 ± 225.2, which improved 97.8% of injections. The most notable adverse events reported were 1 patient with vasovagal syncope and 1 patient with flu-like symptoms after injection. Limb dystonia data recorded subjective improvement in all patients, and only 1 patient had focal weakness. In 2 cases of closed jaw LTLC, both improved and had no side effects. All of the above side effects were transient and mild.

Conclusion: Dystonia involves predominantly the facial and neck muscles, mainly of idiopathic origin. Research has demonstrated its effectiveness in improving symptoms of muscle dystonia, similar to studies conducted worldwide in hemifacial spasm, blepharospasm, and cervical dystonia, with less effectiveness in arm dystonia. Local side effects are quite common in hemifacial spasm and blepharospasm, while they are rare in other forms.

Key words: focal dystonia, Abobotulinum, Botulinum toxin injection, cervical dystonia, blepharospasm, hemifacial spasm, oromandibular dystonia, limb dystonia.
UMA PROVA DA IRRACIONALIDADE DE 2N√ P, EM QUE P É PRIMO, POR MEIO DA TEORIA DOS RESÍDUOS QUADRÁTICOS
Authors: Jackson Soares Isneri Renan , Lopes Vieira Vandenberg , Aires Maxwell
Published: March 2024

Os números primos desempenham um papel fundamental na Teoria dos Números e têm aplicações que v˜ao além da Matemática. Em particular, na Teoria dos Códigos e também na Criptografia, as propriedades dos números primos s˜ao relevantes, porque, a partir delas, ´e possível garantir o armazenamento de dados e o envio de mensagens de forma segura. E isto se evidencia no comércio eletrônico quando dados pessoais devem ser mantidos sob sigilo. A prova de que √p ´e um número irracional, para todo primo positivo p, ´e conhecida, se n˜ao por todos, mas pela maioria dos estudantes de Matemática, e tal prova ´e, em geral, dada por meio de uma propriedade básica dos números primos: se p divide o produto de dois inteiros, então, ele divide ao menos um deles. Tal resultado ´e base de outros n˜ao menos importantes, como, por exemplo, o que ´e dado pelo Teorema Fundamental da Aritmética, que vem a ser o resultado basilar da Teoria dos Números. Neste artigo, apresentamos uma prova da irracionalidade de p1/2n por meio de resultados da Teoria dos Resíduos Quadráticos, especialmente, pela Lei da Reciprocidade Quadrática de Gauss.
Palavras-chave: Número irracional; Número primo; Resíduo quadrático; Reciprocidadequadrática.
Construction of Self in Aravind Malagatti’s Government Brahmana
Authors: Gautam C , Narasimha Murthy S V
Published: March 2024

The issues based on caste, gender, and religion have been imprinted upon the medium of art. The canvas of literature has many a time laid focus on the discrimination based on caste. This theme has been etched in different hues. The subject of being dominated, discriminated, and the stigma attached to it has been justified by the individual ideologies of Dalit and Non-Dalit writers. But in this prominent autobiographical work titled Government Brahmana, by Arvind Malagatti there is a different perspective is presented. Dalit autobiographies speak about the rampant practices of intolerance towards Dalits and have significantly impacted society, In a step ahead, Arvind Malagatti Dalitatva is the literature that has the flow of Dalit consciousness throughout. This autobiography Government Brahmana speaks about various sagas the writer witnessed in different stages of life. In the beginning, he justifies the title Government Brahmana by considering the benefits given by the government to Dalits in comparison to the ideology of Brahmanism which was in practice from Sanatana Dharma. Later he draws the attention of readers by revealing how his name was misinterpreted in school and a variety of punishments imposed on him. He also writes about the ways in which the society marginalized the people belonging to his community in the name of untouchables. His writings not only interpret the chaos of marginalization but also reflect the consciousness of constructing his identity in tackling the hurdles. This apparently resulted in oppression and alienation after the country became sovereign. Apart from this, he has been able to contemplate his narrative style using his special dialect to withstand the interest of readers in the original text. It is good to know that the same has been achieved in the translational work by translators.
Navigating Digital Frontiers: The Impact and Influence of Social Media in Modern Marketing
Authors: Udhayalakshmi G
Published: March 2024

This study focuses on the profound impact of social media on digital marketing and customer behaviour. Social media has evolved significantly over time, transitioning from platforms such as Usenet to the current domination of TikTok and Instagram. It has now become essential for organisations aiming to have a strong online presence. Businesses have adjusted their marketing tactics to take use of social media’s dynamic characteristics, since they understand the potential for direct contact with customers. This research emphasises the current significance of understanding social media platforms as crucial tools for developing meaningful interactions with target audiences. The research aims include investigating the historical development, examining marketing tactics, and evaluating their influence on customer behaviour. An all-encompassing technique, which combines qualitative and quantitative methods, guarantees a detailed comprehension via the examination of literature, analysis of case studies, and interviews with experts.
Role of Startups in Entrepreneurship Development (Agri Based Sector)
Authors: Veni J
Published: March 2024

An entrepreneurial mentality drives a thriving economy. Entrepreneurship improves quality of life, access to goods and services, and economic progress. Many company entrepreneurs improve their life and those of others by fighting poverty or creating eco-friendly products. Entrepreneurship is thought to boost economic growth by fostering innovation, market expansion, change, and wealth creation. Entrepreneurs are essential for inventing new products, ideas, and solutions. Innovative supply chain management, precision farming, and market connection solutions are coming from agritech firms. These changes may boost farmers’ income, expenditure, and productivity. Company expansion and riches boost tiny towns and hamlets. The cycle continues endlessly because growth and money inspire additional businesses, which boost growth and money. Startups help people support their families by providing jobs. Startups alleviate unemployment by creating new jobs. Jobs like this, which take a lot of education and expertise yet pay well, build the middle class. Technology and economic growth are rising.
Optimizing Workforce Stability: Unraveling the Influence of Talent Management Strategies on Employee Retention
Authors: Mary Sudharshini F
Published: March 2024

This research examines the complex connections among talent management strategies, employee engagement, and retention in the information and technology industry in Selangor. The study endeavours to reveal distinct tactics and practices that foster a dedicated and enduring staff in an ever-changing business, using a combination of qualitative and quantitative approaches. This study focuses on assessing the efficacy of talent management techniques and explores the consequences and significance of different talent management approaches in modern company settings. The research aims to get a thorough knowledge of how various methods might effectively achieve organisational objectives by conducting a detailed evaluation of existing literature and analysing empirical data. The research examines case studies, industry analysis, and expert opinions to understand the intricate processes that lead to a resilient and dedicated workforce. The objective of the research is to provide guidance to organisations on how to enhance the stability of their personnel by implementing strategic talent management activities.
Influencer Marketing Unveiled: A Conceptual Exploration of Emotional Marketing, Consumer Connections, and Future AI Trends
Authors: Gaur Preethi
Published: March 2024

This research aims to get a conceptual knowledge of influencer marketing, as well as its relationship with emotional marketing. Emotional marketing is considered a component of influencer marketing, since customers form an emotional connection with the influencers. An analysis has been conducted to investigate the level of emotional connection that may be formed between influencers and customers across many categories, including nano influencers, micro influencers, and celebrities. Influencers use several methods such as authenticity, narrative, engagement, and interaction to control customers’ purchasing attitude and intention. These strategies enable influencers to develop an emotional connection with consumers. These strategies assist in quantifying the influence on customers by analysing their purchases. The future trajectory of marketing, with a focus on the integration of AI, has been thoroughly examined, along with a comprehensive analysis of the potential impact of influencer marketing.
Partizipation in der Entwicklung des Lerngegenstandes - ein demokratisches Potential von Lernwerkstätten
Authors: Rauterberg Marcus
Published: March 2024

Im Anschluss eine Konzeptionsskizze der „Werkstatt Sachlernen in Früher Bildung und Grundschule“ an der Pädagogischen Hochschule Ludwigsburg greift der Beitrag für seine Überlegungen zu Partizipation im Kontext didaktischer Werkstätten eine Differenzierung von Henneberg/Klein auf. Die Autor:innen unterscheiden Entscheidungsmacht und Deutungsmacht, wobei im Weiteren dann die Frage der Mit-Deutung, der Mitbestimmung über den Lerngegenstand als Potential der Werkstattarbeit im Fokus steht. Damit kann das Konzept Werkstatt als anschlussfähig an inklusive und adaptive Überlegungen gesehen werden. (DIPF/Orig.)
Rollen, Materialien und Lernen in Hochschullernwerkstätten - zum Stand der Diskussion im Rahmen der AG Begriffsbestimmung
Authors: Herrmann Franziska , Kihm Pascal
Published: March 2024

Die AG Begriffsbestimmung des NeHle e.V. widmet sich seit deren Gründung (2018) dem Auftrag, eine Definition des Begriffs Hochschullernwerkstatt zu erarbeiten, die der Vielfalt von Hochschullernwerkstätten entspricht und gleichzeitig deren spezifische Merkmale herausstellt. Nachdem ein erster Entwurf der Arbeitsdefinition veröffentlicht wurde, ging es im weiteren Prozess um die begriffliche Schärfung einzelner Textpassagen. Es zeigte sich, dass es Kernthemen gibt, die der fokussierten theoretischen Auseinandersetzung und expliziten Diskussion bedürfen. Der Beitrag stellt drei dieser Themen in den Mittelpunkt: die Frage nach den Rollen von Akteur:innen, das Thema Materialien und die lerntheoretische Grundlegung von bzw. in Hochschullernwerkstätten. Daran anschließend erfolgt ein Ausblick auf die weiterführende Arbeit im Rahmen der AG Begriffsbestimmung. (DIPF/Orig.)
Hochschuldidaktische Werkstatt: Partizipation und Kooperation im Grundschullehramt
Authors: Kopp Maximilian , Frei-Kuhlmann Janika , Seifert Anja
Published: March 2024

Der Beitrag fokussiert das Projekt „Mentoring: Erfolgreich L1 studieren“ (MERLIN), welches initiiert wurde, um den Übergang für Studienanfänger:innen an die Hochschule zu begleiten. MERLIN gliedert sich in ein „Mentoring-Programm“ und die „Hochschuldidaktische Werkstatt“ (HDW). Die HDW - die im Vordergrund des Beitrages steht - hat das Ziel, neben der Stärkung der Kooperation und Kollaboration von Dozent:innen, die im Grundschullehramt lehren, auch zur Förderung der Partizipation der Studierenden an der Studiengangsentwicklung beizutragen. Zunächst wird die HDW in ihrer Umsetzung und Funktion im Grundschullehramt der Justus-Liebig-Universität Gießen erläutert. Danach findet eine Analyse der HDW anhand von Qualitätsmerkmalen für Lernwerkstätten statt. Hiernach geht der Beitrag näher auf das zugrunde liegende Verständnis von Kooperation und Kollaboration sowie intendierter partizipativer Prozesse in der HDW ein. Der Beitrag schließt mit einer Diskussion, inwiefern das Konzept der HDW ein wirksames Werkzeug zur Förderung von Partizipation, Kooperation und Kollaboration darstellt und somit letztendlich auch zur Studiengangsentwicklung beiträgt. (DIPF/Orig.)
Die Bedeutung affektiver Dimensionen im Versuch einer Anbahnung von Partizipation im Raum der Hochschullernwerkstatt (HSLW). Sensibilisierung für Bildung für nachhaltige Entwicklung
Authors: Spuller Siglinde
Published: March 2024

Dieser Artikel nimmt die Bedeutung affektiver Dimensionen in partizipativen Bildungsansätzen in den Blick, insbesondere im Kontext der Bildung für nachhaltige Entwicklung. Er betont das Zusammenspiel von Emotionen, Motivation und aktiver Beteiligung in Bildungsprozessen und unterstreicht die Bedeutung positiver emotionaler Erfahrungsräume für die Förderung von Partizipation. Auf diesem konzeptionellen Hintergrund wurden im Rahmen eines Seminars zum Thema „Spiele in der Grundschule“ nachhaltige Entwicklungsthemen integriert. Durch interaktive Methoden sowie durch kreative und partizipative Ansätze erkundeten die Studierenden diese Themenfelder. Dabei deuten die Ergebnisse darauf hin, dass der spielerische Fokus positive Emotionen, Kreativität und Motivation bei den Studierenden hervorrief und damit das Potenzial affektiver Dimensionen zur Verbesserung partizipativer Lernerfahrungen beförderte. Um jedoch mögliche langfristige Auswirkungen solcher partizipativen Methoden auf Umweltbewusstsein und Verhalten zu untersuchen, ist die Notwendigkeit weiterer Forschung zu unterstreichen. (DIPF/Orig.)
The Effect of Early Home Learning Activities on Achievement at the End of Primary Education
Authors: Kennedy Alec I. , Strietholt Rolf , Hogrebe Nina , Strello Andrés
Published: March 2024

Early home learning activities such as book reading and playing with number toys are expected to impact children's development. However, isolating the effects of these activities is challenging due to the correlation between parental engagement and socioeconomic background, which influences how children are raised and supported. Even longitudinal studies can be distorted by this correlation. Therefore, we adopt an alternative approach and relate differences in early home literacy and numeracy activities to differences in later reading and math performance. Applying this approach to data from 37 countries suggests an overall positive effect of early home learning activities on achievement in fourth grade. Given their lower prevalence in disadvantaged households, targeted policies supporting parental engagement may help reduce socioeconomic achievement gaps.
System Literature Review: Implementasi Metode Pembelajaran Bahasa Arab dalam Mempelajari Kitab Kuning
Authors: Hamidi Furqon , Handican Rhomiy
Published: March 2024

This study aims to review the literature on learning methods for studying the Yellow Book. The technique used in this research is SLR (System Literature Review). Data collection is done by identifying or reviewing all articles that have the same research topic as this research. The articles used in this study were 16 journal articles obtained from the Google Scholar database using Harzing's Publish or Perish application. The results of this study reveal several Arabic learning methods used in studying the Yellow Book; information is obtained that learning methods are found in the articles collected, which focus on the implementation of the method of learning the Yellow Book. Which, in this case, only takes the Tamyiz Method, the Al-Miftah Lil Ulum Method, the Bandongan Method, and the Sorogan Method. The results of this study are expected to provide benefits for learning and be used as examples of the use of various Arabic language concepts around us.
 
Penelitian ini bertujuan untuk melakukan kajian literatur review terkait dengan metode pembelajaran dalam mempelajarai kitab kuning. Metode yang digunakan dalam penelitian ini adalah SLR (System Literature Review). Pengumpulan data dilakukan dengan mengidentifikasi atau menelaah semua artikel yang memiliki topik penelitian yang sama dengan penelitian ini. Artikel yang digunakan pada penelitian ini sebanyak 16 artikel jurnal yang diperoleh dari data base google scholar dengan menggunakan aplikasi Harzing’s Publish or Perish. Hasil penelitian ini mengungkapkan bahwa ada beberapa metode pembelajaran bahasa arab yang digunakan dalam mempelajari kitab kuning diperoleh informasi bahwasannya ditemukan metode pembelajran pada artikel yang dikumpulkan yang berfokus pada Implementasi Metode, Pembelajaran Kitab Kuning. Yang dalam hal ini hanya mengambil Metode Tamyiz, Metode Al-Miftah Lil Ulum, Metode Bandongan, dan Sorogan. Hasil dari penelitian ini diharapkan akan memberi manfaat bagi pembelajaran dan digunakan sebagai contoh penggunaan berbagai konsep bahasa arab disekitar kita.