bluuebunny/crossref_metadata_2025 huggingface dataset:
Yaşam Doyumuyla Bilinçli Farkındalık Arasındaki İlişki: Yetişkinler Üzerine Bir Araştırma
Authors: PARMAKSIZ İzzet
Published: April 2020

Bu çalışmada yetişkin bireylerde yaşam
doyumu ile bilinçli farkındalık arasındaki eğrisel ve doğrusal ilişkileri
saptamak amaçlanmıştır. Araştırma örneklemi Orta Anadolu’da yaşayan 376
(Kadın:194, Erkek:182) yetişkin katılımcıdan oluşmaktadır. Verilerin analizinde
evli bireylerin bilinçli farkındalığı ile yaşam doyumu arasında anlamlı bir
ilişki bulunmadığından sadece bekâr katılımcıların puanları regresyon analizine
dâhil edilmiştir. Yapılan analizlerde medeni durumun yaşam doyumu puanlarını
anlamlı farklılaştırdığı bulunmuştur. Buna karşın cinsiyet, yaşanan yer, eğitim
düzeyi ve algılanan ebeveyn tutumu anlamlı bir farklılık oluşturmamıştır. Bekâr
katılımcıların bilinçli farkındalığı ile yaşam doyumu arasında anlamlı bir
ilişki varken evli katılımcılarda anlamlı bir ilişki saptanmamıştır. Yapılan
regresyon analizinde katılımcıların yaşam doyumu ile bilinçli farkındalıkları
arasında pozitif doğrusal ilişki olduğu buna karşın eğrisel bir ilişkinin
olmadığı saptanmıştır. Bireylerin yaşam doyumunu artırmak, önleyici ve koruyucu
ruh sağlığı hizmetlerini sağlamak için yapılacak etkinliklerde bilinçli
farkındalık sağlayıcı çalışmalara yer vermek faydacı bir tutum olarak karşımıza
çıkmaktadır. Bu nedenle bilinçli farkındalık temelli uygulamaların ve
psikolojik danışma müdahalelerinin artırılması gerekmektedir. Ayrıca bilinçli
farkındalık eğilimini sağlayan eğitsel faaliyetlerin de eğitim ortamlarına
taşınması ve ebeveynlerin çocuklarını yetiştirirken bu tutumu kazandırması önem
arz etmektedir.
Processos produtivos de trabalhadores rurais no extrativismo da palha de carnaúba
Authors: Ximenes Neto Francisco Rosemiro Guimarães , Ponte Crispim Francisca Sandra da , Braga Petrônio Emanuel Timbó
Published: April 2020

O estudo objetivou cartografar o processo produtivo dos trabalhadores rurais no extrativismo da palha de carnaúba. Pesquisa descritiva, do tipo estudo de caso, desenvolvida em Cariré – Ceará, entre maio de 2016 e junho de 2017, com 18 trabalhadores rurais. O extrativismo da palha envolve corte, manuseio de animais, armazenamento inadequado, entre outros, que podem influir diretamente no processo saúde-doença-cuidado-trabalho.
Avaliação da Expansão do REUNI UFGD no Mato Grosso do Sul
Authors: Gumiero Rafael Gonçalves
Published: April 2020

O objetivo deste artigo é o balanço da expansão do REUNI em Mato Grosso do Sul e em Dourados, avaliando se houve desconcentração das universidades federais públicas das metrópoles para o interior do Brasil. A metodologia aplicada foi a coleta de dados quantitativos secundários que correspondem aos indicadores de expansão do Reuni, nos sites do Instituto Nacional de Estudos e Pesquisas Educacionais Anísio Teixeira (INEP), Ministério da Educação (MEC), Sistema de Informações Georreferenciadas da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (GeoCapes).
O significado do declínio organizacional: o caso UFN III
Authors: Vasconcelos Eveli Freire , Bastos Antonio Virgílio Bittencourt
Published: April 2020

Esta pesquisa buscou descrever as significações das experiências de ex-funcionários da construção da Unidade de Fertilizantes Nitrogenados III em Três Lagoas, MS, a partir do fenômeno de declínio organizacional. A metodologia consistiu de análise documental e entrevistas.  Nos resultados organizaram-se as ideias centrais do conteúdo dos relatos em mapas coletivos que representam o esquema cognitivo do declínio organizacional. As conclusões do estudo evidenciam que o fenômeno ainda é muito pouco explorado, especialmente tendo o indivíduo como unidade de análise.
A Cooperativa Fernheim dos imigrantes menonitas de Filadélfia, Paraguai
Authors: Costa Odemir Coelho da , Hoff Sandino
Published: April 2020

O presente artigo tem por objetivo geral analisar a mediação exercida pela Cooperativa Fernheim, de Filadélfia, Paraguai, entre o produtor, a comercialização e a industrialização do produto. A Cooperativa desempenha um importante papel para o desenvolvimento regional do Chaco Central, não só a partir da industrialização de produtos e comercialização, mas também, com as inovações implantadas para o manuseio da água. A problematização do objeto de estudo orienta-se para os seguintes questionamentos: quais as ações efetuadas pela Cooperativa Fernheim que propiciam o desenvolvimento econômico e social dos cooperados? Qual a importância da Cooperativa para a comercialização e a industrialização dos produtos? Como é efetuada a aplicação financeira da Cooperativa e para quais setores são direcionados os créditos dos cooperados? Quais as inovações tecnológicas desenvolvidas pela Cooperativa para o tratamento da água salobra que auxiliam no desenvolvimento do município? Os questionamentos são sintetizados nos objetivos específicos: verificar as atividades produtivas que a Cooperativa oferece ao produtor rural, enquanto apoio ao financiamento, à compra e industrialização dos produtos vegetais e animais; e analisar as inovações tecnológicas que possibilitaram o abastecimento e o consumo da água, originalmente salobra. A sistematização dos dados foi realizada pela Análise de Conteúdo de Bardin. Como aporte teórico, adotamos a teoria da história que investigou os pormenores das ações econômicas e sociais realizadas pela Cooperativa, consideradas como manifestações singulares do movimento geral do capital.
Viabilidade econômica para implantação de um biodigestor: uma alternativa para o pequeno produtor rural suinocultor
Authors: Anis Cintia Ferreira , Pietramale Rita Therezinha Rolim , Gimenes Régio Márcio Toesca , Ribeiro Vinícius de Oliveira
Published: April 2020

A produção brasileira de suínos traz retornos positivos ao agronegócio, mesmo com fatores prejudiciais ao meio ambiente que ocorrem devido ao potencial poluidor dessa atividade, em razão do manuseio inadequado do esterco suíno. Reduzir esses impactos requer o uso de sistemas eficientes e sustentáveis de tratamento de resíduos. O objetivo deste estudo foi analisar a viabilidade econômica da implantação de um sistema de biodigestor para o tratamento de resíduos de uma planta de criação de 1.500 porcas, possibilitando a produção de biogás como fonte alternativa de energia elétrica limpa. Para tanto, utilizou-se de pesquisa bibliográfica sobre a temática e do desenvolvimento de cenários possivelmente realísticos. Dois cenários de investimento foram comparados: I) 20% de patrimônio e 80% de financiamento; e II) 100% do patrimônio líquido. Concluiu-se que os investimentos também são sustentáveis e economicamente viáveis nas duas situações, sendo o II o mais vantajoso, que apresentou menor risco com base na TIR, VPN e IL calculadas.
Características de pacientes com indicação de cuidados paliativos em uma unidade de cuidados prolongados em Campo Grande, Mato Grosso do Sul
Authors: Vidal Bravalhieri Anna Alice , Miziara Barbosa Suzi Rosa , Bregolato Rubira de Assis Maria de Fátima , Moraes Penha Ramon
Published: April 2020

Cuidado paliativo (CP) é uma abordagem que promove alívio de sofrimento de pessoas com doenças incuráveis que ameaçam a continuidade da vida. O objetivo deste estudo foi traçar as características dos pacientes com indicação de CP em uma unidade de cuidados prolongados (UCP). Trata-se de um estudo transversal, quantitativo, retrospectivo e com coleta de dados em prontuário. No período do estudo, houve 389 admissões na UCP e, dessas, 31 prontuários foram incluídos para este estudo. Destacou-se a população idosa, compondo mais de 80% da amostra; 54,8% eram mulheres, acometidas principalmente por doenças crônicas relacionadas ao processo de envelhecimento, como as doenças neurodegenerativas e com internação de curto prazo; e 84% foram a óbito. Foi observada a necessidade de fortalecimento dos CPs na Atenção Primária de Saúde, para que os pacientes que receberem alta hospitalar possam receber todo o auxílio e suporte com qualidade em domicílio.
Análise da força muscular de membros inferiores em idosos: uma revisão sistemática
Authors: Bini Viviane Eloisa , De Freitas Nei Adão Ribeiro , Mascarenhas Luis Paulo Gomes
Published: April 2020

A capacidade de gerar força muscular nos membros inferiores (MMIIs) é um dos preditores mais importantes do status funcional em idosos e apresenta relação direta com quedas e fraturas. O salto vertical com contramovimento − Countermovement Jump (CMJ) − é uma habilidade motora fundamental na realização de inúmeras atividades, uma vez que demanda um desempenho coordenado do corpo com recrutamento muscular. Foram realizadas buscas nas bases de dados: PubMed, Bireme, SciELO e PEDro. As palavras-chave foram selecionadas de acordo com os Descritores em Ciência da Saúde (DeCS), para abordar o uso do CMJ em idosos. Dos 39 estudos encontrados, 11 foram selecionados e avaliados pela escala PEDro e apresentaram boa qualidade metodológica. O salto vertical com contramovimento se mostrou proveitoso na avaliação de força e potência em idosos.
Práticas de redução do desperdício de alimentos: o caso de um projeto social em Santarém, Pará
Authors: Cardoso Ana Mirelle Almeida , Vieira Thiago Almeida
Published: April 2020

Neste artigo, estudamos a experiência do Programa Mesa Brasil (SESC) na cidade de Santarém, Pará, no que tange à doação de alimentos por feirantes da Feira Mercadão 2000. A deterioração dos produtos foi o principal critério de seleção do alimento a ser doado pelos feirantes. Em seis meses de observação, foram doados 34.513 kg de alimentos. O Programa Mesa Brasil se apresenta como iniciativa promissora ao reaproveitamento de alimentos, atendendo a mais de 21.000 pessoas nesta cidade. Os resultados encontrados neste trabalho apontam a importância da sensibilização dos feirantes e da sociedade em geral quanto ao desperdício de alimentos, por meio de ações individuais ou coletivas.
O Sanatório São Julião na mídia impressa campo-grandense (1941-1970): um estudo historiográfico
Authors: Vilena Kely Cristina Garcia , Miranda Rodrigo Lopes
Published: April 2020

O objetivo deste trabalho é apresentar e discutir a forma como o Sanatório São Julião circulou na mídia impressa campo-grandense, entre 1941 e 1970. Estima-se analisar, por meio do discurso midiático, práticas de assistência ao Sanatório e aos seus internos, por parte da sociedade. As fontes primárias utilizadas foram notícias publicadas em jornais, disponíveis no Arquivo Municipal de Campo Grande (ARCA), a saber: Correio do Estado, O Matogrossense e o Jornal do Comércio. As análises do material sugerem que a sociedade campo-grandense, movida por certa visão social da lepra, manifestada pela mídia impressa, “amparou” os internados no Sanatório São Julião com doações de diversos gêneros, desde alimentos a expressivos valores, efetuados por “generosos” campo-grandenses. Assim, as imagens evocadas pelo discurso midiático, referentes ao Sanatório São Julião, concebem a ideia de um cuidado em saúde ligado a práticas assistencialistas.
Tradução: a mente, a medicina e o homem, por Gregory Zilboorg
Authors: Tiburtino-Silva Lorene Almeida , Silva João Alberto Mendonça , Maciel Josemar de Campos
Published: April 2020

O psicanalista e historiador da psiquiatria, Dr Gregory Zilboorg, nascido russo e naturalizado americano, trabalhou por anos, aspectos da psiquiatria dentro de um contexto sociológico e humanístico. Durante sua carreira escreveu diversas obras de brilhante ilustração de conceitos para leigos. Seus livros são raros, mesmo em buscas virtuais, sendo poucas e privilegiadas bibliotecas possuem exemplares. Além deles, Zilboorg também produziu uma série de artigos clínicos, que discutem desde a personalidade esquizoide até as relações entre o direito e a psiquiatria. Aqui traduzimos parte de um capítulo de seu livro Mind, Medicine & Man. Nesse trecho, Zilboorg ilustra a ideia de psiquismo humano a partir de uma brilhante descrição da ameba que, como ser vivo unicelular e que percebe o mundo a partir de sua única célula, desenvolve um estilo próprio de comunicação com o ambiente. Zilboorg defende que o fenômeno psíquico envolve toda a corporeidade humana, analogamente ao ser vivo multicelular, para que o conjunto de informações se traduza nos diversos sistemas psíquicos.
Nivel de satisfacción de los pacientes que reciben atención fisioterapéutica en el departamento de unidad motora y dolor del Instituto Nacional de Rehabilitación
Authors: Garcia Alvarado Diandra Laurence , Guillinta Garcia Estefany Lizbeth , Cabello Morales Emilio , Santillán Ortega Julio
Published: April 2020

Objetivo: Determinar el nivel de satisfacción de los pacientes que recibieron atención fisioterapéutica en el Departamento de Unidad Motora y Dolor del Instituto Nacional de Rehabilitación (INR) en Lima, Perú; y la descripción de características sociodemográficas, académicas y clínicas. Material y métodos: Estudio transversal realizado en 280 pacientes que recibieron atención fisioterapéutica en el INR, durante los meses de agosto a noviembre del 2015. Se evaluó el nivel de satisfacción de los pacientes mediante el cuestionario SERVQUAL modificado. Resultados: El nivel de satisfacción global fue de 76,4%. Se encontró mayor satisfacción en la dimensión elementos tangibles (78,8%), seguido de seguridad (77,9%), empatía (76,3%). fiabilidad (67,6%) y capacidad de respuesta (55,0%). Conclusiones: El nivel de satisfacción global en los pacientes evaluados fue aceptable. La dimensión capacidad de respuesta mostro la menor satisfacción por la cual recomendamos implementar medidas que permitan su incremento.
Utilidad de la terapia asistida con perros en la volición de niños con parálisis cerebral en segundo grado de primaria del Colegio la Alegría en el Señor, La Molina, setiembre 2013. Estudio piloto
Authors: Flores Cortijo Rosario Katherine , Lino Salvador Gina Cecilia
Published: April 2020

Objetivo: Evaluar si la terapia asistida con perros es útil en la volición de niños con Parálisis Cerebral en segundo grado de primaria del colegio La Alegría en el Señor.
Material y métodos: La presente investigación es de diseño analítico, cuasiexperimental, no aleatorio con la finalidad de valorar la utilidad de la Terapia Asistida con Perros (TAP) en la volición de un grupo de niños con diagnóstico de Parálisis Cerebral (PC). La población final con la que se trabajó estuvo conformada por 6 niños diagnosticados con PC en 2° de primaria del colegio La Alegría en el Señor (LAS); se brindó a cada participante 12 sesiones de Terapia Ocupacional utilizando como herramienta terapéutica la TAP. Como instrumento de evaluación se utilizó el Cuestionario Volitivo Pediátrico (PVQ) – Hoja C; este instrumento fue aplicado a cada participante en tres momentos (1°, 6° y 12° sesión). Resultados: Los resultados obtenidos desde la Sesión I hasta la III muestran incremento progresivo del grado de expresión volitiva, relacionada a la participación del perro de terapia. Finalmente los resultados indican relación entre variables y se muestran a favor de la hipótesis planteada (La TAP es útil en la volición de niños con PC en  2° grado de primaria del colegio LAS).  Los resultados evidencian que los componentes volitivos fueron impactados de forma positiva por la presencia del Perro de Terapia, esto se refleja en los resultados obtenidos, donde finalizado el estudio los indicadores volicionales alcanzaba en el 100% de niños la etapa de logro. Conclusiones: La TAP es útil para desarrollar la volición de niños con PC en 2° de primaria del colegio LAS.
Determination of the Runoff Coefficient (C) in Catchments Based on Analysis of Precipitation and Flow Events
Authors: Cardoso Tais , Machado Ronalton , Mortene Matheus
Published: April 2020

The runoff coefficient (C) represents the relationship between the surface runoff volume and the precipitated volume. It is used in engineering projects for flood estimation methods. Although C values are tabulated and consecrated in hydrological engineering, as if they were constant, they may not correspond to the reality, because in the same catchment, they can vary according to the intensity, temporal and spatial distribution of precipitation events, humidity conditions, and ground cover. This study had the objective of analyzing extreme events of precipitation and the corresponding flows to obtain experimental runoff coefficients (C) and compare them with the tabulated values. The study was conducted in four experimental catchments in the State of São Paulo, Brazil, with different land uses and soils. The runoff coefficients (C) were obtained from the analysis of hydrograms and using a digital filter, which allowed the separation of the direct runoff, of the total flow. When analyzing flow and precipitation data in different seasons of the year, selecting events of the floods of catchments and separating the flows, we observed a variation of the flow coefficient values, different from those obtained from tables.
Study of Wine Producers' Marketing Communication in Extreme Territories - Application of the AGIL Scheme to Wineries Websites Features
Authors: Chironi Stefania , Altamore Luca , Columba Pietro , Bacarella Simona , Ingrassia Marzia
Published: April 2020

This study measures the communication ability of wineries in two extreme territories of Southern Italy, Mount Etna and the island of Pantelleria. The evaluation of four dimensions of web communication was carried out by the AGIL Scheme (i.e. adaptation, goal-attainment, integration, latent pattern maintenance). The study provides a generalizable model to be applied in other similar studies. Also, focus groups of experts were carried out. The method proved to be suitable to measure the communication effectiveness of wineries through websites. Extreme territories may add value to the wine, regardless of the brand. The heroic wines may become the symbol of these territories helping environmental safeguard and contrasting territory abandonment by rural communities. The findings highlight that effective communication of heroic viticulture may be used to reposition these wines and increase their competitive advantage in foreign markets. The study generates new ideas for reflection on new types of web communication.
Investigation of the Influence of PLA Molecular and Supramolecular Structure on the Kinetics of Thermal-Supported Hydrolytic Degradation of Wet Spinning Fibres
Authors: Giełdowska Małgorzata , Puchalski Michał , Szparaga Grzegorz , Krucinska Izabella
Published: April 2020

In this study, differences in the kinetics of thermal-supported hydrolytic degradation of poly(lactic acid) (PLA) sample wet spinning fibres due to material variance in the initial molecular and supramolecular structure were analysed. The investigation was carried out at the microstructural and molecular levels by using readily available methods such as scanning electron microscopy, mass erosion measurement and estimation of intrinsic viscosity. The results show a varying degree of influence of the initial structure on the degradation rate of studied PLA fibres. The experiment shows that hydrolytic degradation at a temperature close to the cold crystallization temperature on a macroscopic level is definitely more rapid for the amorphous material, while on a molecular scale it is similar to a semi-crystalline material. Further, for the adopted degradation temperature of 90 °C, a marginal influence of pH of the degradation medium on the degradation kinetics was also demonstrated
Highly Porous Platinum Electrodes for Dry Ear-EEG Measurements
Authors: Eickenscheidt Max , Schäfer Patrick , Baslan Yara , Schwarz Claudia , Stieglitz Thomas
Published: April 2020

The interest in dry EEG electrodes has increased in recent years and especially as everyday suitability earplugs for measuring drowsiness or focus of auditory attention. However, the challenge is still the need for a good electrode material, which is reliable and can be easily processed for highly personalized applications. Laser processing as used here is a fast and very precise method to produce personalized electrode configurations that meet the high requirements of in-ear EEG electrodes, for example. The arrangement of the electrodes on the very flexible and compressible mats allows an exact alignment of the electrodes to the ear mold and contributes to a high wearing comfort, as no edges or metal protrusions are present. For better transmission properties, an adapted coating process for surface enlargement of platinum electrodes is used, which allows easy control of the thickness and growth form of the porous layer. The porous platinum-copper alloy is chemically very stable, shows no exposed copper residues and enlarges the effective surface area by 40. In a proof-of-principle experiment, these porous platinum electrodes could be used to measure the Berger effect in a dry state using just one ear of a test person. Their signal-to-noise ration and frequency transfer function is comparable to gel-based silver/silver chloride electrodes.
ACE-1 I/D Polymorphism Associated with COVID-19 Incidence and Mortality: An Ecological Study
Authors: Kenyon Chris
Published: April 2020

A literature review was conducted to summarize the frequency of the D-allele of the angiotensin-converting enzyme-1 in all countries with available data. Using an ecological study design limited to high income countries, we found that the country-level frequency of the D-allele was associated with increased COVID-19 incidence and mortality.
A Brief Theory of Epidemic Kinetics
Authors: Louchet Francois
Published: April 2020

In the context of the COVID-19 epidemic, and on the basis of the Theory of Dynamical Systems, we propose a simple model for the expansion of contagious diseases, with a particular focus on viral respiratory tracts. The infection develops through contacts between contagious and exposed people, with a rate proportional to contact duration and turnover, inversely proportional to the efficiency of protection measures, and balanced by the average immunological response. The obvious initial exponential increase is readily hindered by the size reduction of the exposed population. The system converges towards a stable attractor whose value is expressed in terms of the ratio C/D of contamination vs decay factors. Decreasing this ratio below a critical value leads to a tipping point beyond which the epidemic is over. By contrast, significant values of C/D may bring the system through a bifurcating hierarchy of stable cycles up to a chaotic behaviour.
A Suggestion from South Korea for Treatment of Mild or Asymptomatic COVID-19 Infected Patients: Living and Treatment Support Center
Authors: Lee Sun Young , Kang EunKyo , Kim Yon Su , Cho BeLong , Kim Min Sun , Jung Hyemin
Published: April 2020

With the outbreak of coronavirus disease 2019 (COVID-19), there is a need for efficient management of patients with mild or no symptoms, which account for the majority. The aim of this study is to introduce the structure and operation protocol of a living and treatment support centre (LTSC) operated by Seoul National University Hospital in South Korea. The existing accommodation facility was converted into a 'patient centre' where patients was isolated. A few Medical staff here performed medical tests and responded to emergencies. Another part of the LTSC was 'remote monitoring centre'. In this center, patients’ self-measured vital signs and symptoms were monitored twice a day, and the medical staff staying here provided video-consultation via a smartphone. During the 3 weeks from March 5 to March 26, 2020, 113 patients were admitted and treated. LTSC could be an efficient alternative to hospital admission in pandemic situation like COVID-19.
Modeling the Novel Coronavirus (SARS-CoV-2) Outbreak in Sicily, Italy
Authors: Maugeri Andrea , Barchitta Martina , Battiato Sebastiano , Agodi Antonella
Published: April 2020

Italy was the first country in Europe which imposed control measures of travel restrictions, quarantine and contact precautions to tackle the epidemic spread of the novel coronavirus (SARS-CoV-2) in all its regions. While such efforts are still ongoing, uncertainties regarding SARS-CoV-2 transmissibility and ascertainment of cases make it difficult to evaluate the effectiveness of restrictions. Here, we employed a Susceptible-Exposed-Infectious-Recovered-Dead (SEIRD) model to assess SARS-CoV-2 transmission dynamics, working on the number of reported patients in intensive care unit (ICU) and deaths in Sicily (Italy), from 24 February to 13 April. Overall, we obtained a good fit between estimated and reported data, with a small fraction of unreported SARS-CoV-2 cases (19.5%; 95%CI=0%-34.7%) before 10 March lockdown. Interestingly, we estimated that the first set of restrictions reduced transmission rate in the community by 42% (95%CI=38%-46%), and that more stringent measures adopted on 23 March succeeded to drastically curb the transmission rate by 84% (95%CI=80%-88%). Thus, our estimates delineated the characteristics of SARS-CoV2 epidemic before restrictions taking into account unreported data. Further modeling after the adoption of control measures, moreover, indicated that restrictions reduced SARS-CoV2 transmission considerably.
Structural Deviation and Identification of Novel Inhibitor of SARS-CoV-2 Spike Protein Through Molecular Docking: An In Silico Study
Authors: Panja Anindya , Sarkar Aniket
Published: April 2020

Purpose: Pandemic Novel Coronavirus (SARS-CoV-2) has emerger centered from wuhan, China. Structurally homologous spike protein of SARS-CoV-2 receptor is taxonomically homologous with SARS-Cov and SARS associated bat coronavirus. Still now scientists are trying to find out proper vaccine and treatments for this disease. Methods: Systematically we modeled and compared the structure of SARS-CoV-2 spike protein along with Bat Cov, Bat SARS Cov and SARS Cov Urbani. S1 and S2 unit of the coronavirus (SARS-CoV-2) are attached with ACE2 and furin, here we docked 5 Ca+ chelating drugs with these two proteins. Results: Structural comparison with all these spike proteins revealed that less significant but not negligible difference exists among them. Inserted stable nucleotide sequences and corresponding surface exposed peptidal region may be considered as epitope. Docking result with Toxicokinetics and half life of Penicillamine can effectly inhibit the attachment site of spike protein of coronavirus (SARS-CoV-2). Conclusions: Docking summery and the pharmacokinetics with toxicokinetics index recommend that Penicillamine can able to inhibit the infection of SARS-CoV-2.
Clinical, Molecular and Epidemiological Characterization of the SARS-CoV2 Virus and the Coronavirus Disease 2019 (COVID-19): A Comprehensive Literature Review
Authors: Ortiz-Prado Esteban , Simbaña-Rivera Katherine , Gomez-Barreno Lenin , Rubio-Neira Mario , Guaman Linda P. , Kyriakidis Nikolaos , Muslin Claire , Gomez-Jaramillo Ana Maria , Barba Carlos , Cevallos Domenica , Sanchez-San Miguel Hugo , Unigarro Luis , Zalakeviciute Rasa , Gadian Naomi , López-Cortés Andrés
Published: April 2020

Coronaviruses are an extensive family of viruses that can cause disease in both animals and humans. The current classification of coronaviruses recognizes 39 species in 27 subgenera that belong to the family Coronaviridae. From those, at least seven coronaviruses are known to cause respiratory infections in humans. Four of these viruses can cause common cold-like symptoms, while others that infect animals can evolve and become infectious to humans. Three recent examples of this viral jumps include SARS CoV, MERS-CoV and SARS CoV-2 virus. They are responsible for causing severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) and the most recently discovered coronavirus disease during 2019 (COVID-19).COVID-19, a respiratory disease caused by the SARS-CoV-2 virus, was declared a pandemic by the World Health Organization (WHO) on 11 March 2020. The rapid spread of the disease has taken the scientific and medical community by surprise. Latest figures from 14 April 2020 show more than 2 million people had been infected with the virus, causing more than 120,000 deaths in over 210 countries worldwide. The large amount of information we receive every day concerning this new disease is so abundant and dynamic that medical staff, health authorities, academics and the media are not able to keep up with this new pandemic. In order to offer a clear insight of the extensive literature available, we have conducted a comprehensive literature review of the SARS CoV-2 Virus and the Coronavirus Diseases 2019 (COVID-19).
Shigella sonnei Outbreak Investigation During a Municipal Water Crisis—Genesee and Saginaw Counties, Michigan, 2016
Authors: McClung R. Paul , Karwowski Mateusz , Castillo Caroline , McFadden Jevon , Collier Sarah , Collins Jim , Soehnlen Marty , Dietrich Stephen , Trees Eija , Wilt Grete , Harrington Christina , Miller Ashley , Adam Elizabeth , Reses Hannah , Cope Jennifer , Fullerton Katie , Hill Vincent , Yoder Jonathan
Published: April 2020

Objectives. To investigate a shigellosis outbreak in Genesee County, Michigan (including the City of Flint), and Saginaw County, Michigan, in 2016 and address community concerns about the role of the Flint water system.

Methods. We met frequently with community members to understand concerns and develop the investigation. We surveyed households affected by the outbreak, analyzed Shigella isolate data, examined the geospatial distribution of cases, and reviewed available water quality data.

Results. We surveyed 83 households containing 158 cases; median age was 10 years. Index case-patients from 55 of 83 households (66%) reported contact with a person outside their household who wore diapers or who had diarrhea in the week before becoming ill; results were similar regardless of household drinking water source. Genomic diversity was not consistent with a point source. In Flint, no space-time clustering was identified, and average free chlorine residual values remained above recommended levels throughout the outbreak period.

Conclusions. The outbreak was most likely caused by person-to-person contact and not by the Flint water system. Consistent community engagement was essential to the design and implementation of the investigation.
The Use of Small Area Estimates in Place-Based Health Research
Authors: Kong Amanda Y. , Zhang Xingyou
Published: April 2020

Interest in the impact of the built environment on health behaviors, outcomes, and disparities is increasing, and the growing development of statistical modeling techniques has allowed researchers to better investigate these relationships. However, without enough data that are identifiable at smaller geographic levels (e.g., census tract), place-based health researchers are unable to reliably estimate the prevalence of a health outcome at these more granular and potentially more salient neighborhood levels.

When reliable direct survey estimates cannot be produced because of small samples or a lack of samples, estimates based on small area estimation techniques are often used. As place-based health research and the production and secondary use of small area estimates increase, it is critical that researchers understand both the underlying methods used to create these estimates and their limitations. Without this foundation, researchers may fit inappropriate models, or interpret findings inaccurately.

As a demonstrative example, we focus this discussion on the small area health indicator estimates recently produced through the 500 Cities Project by the Robert Wood Johnson Foundation, the Centers for Disease Control and Prevention (CDC), and the CDC Foundation.
Complete Intrasubstance Rupture of the Biceps Brachii Via Atypical Eccentric Contraction
Authors: Parisien Robert L. , Dashe Jesse , Alley Maxwell C. , Stein Andrew
Published: April 2020

Case:

A 46-year-old man presented with extensive swelling and ecchymosis of the arm and antecubital fossa after a 4-foot fall from a ladder in which he attempted to arrest his decent by grabbing onto a wooden ceiling beam. Ultrasound and magnetic resonance imaging confirmed a complete intrasubstance rupture of the biceps brachii. Nonoperative management was recommended and, at 9-week follow-up, the patient had resumed light weightlifting and demonstrated painless full active range of motion.

Conclusions:

Uncommon complete intrasubstance biceps brachii ruptures can occur via an atypical mechanism of isotonic eccentric muscle contraction and satisfactory results may be realized through nonoperative management.
Formula of Yellow Kepok Banana (Musa acuminata x Musa balbisiana) Corm Extracts As Antiinflamation
Authors: Wenas Desy Muliana , Aliya Lisana Sidqi , Anjani Wisma Merry
Published: April 2020

Bananas have many types and benefits. One of them is the Yellow Kepok Banana. Banana stem, leaf midrib, and corm contain phytochemicals compound as medicinal properties. The study aimed to determine the effect of the yellow kepok banana corm extract formula as an anti-inflammatory. Banana corm was cut into 0.3 x 1 x 3 cm pieces, dried in the oven with temperature 60 °C for 6 hours, then made 40 mesh powder. The powder extracted using 70 % ethanol by maceration technique for 24 hours, repeated three times. Anti-inflammatory testing was carried out on male Sprague Dawley white rats. A total of 24 white rats were divided into six treatment groups, consists of different concentrations of the extract (10, 15, and 20 %), positive control (commercial ointment), negative control, and a normal control (giving a wound without being given any formula). The experiment was designed as a randomized complete, with four replications, data were analyzed using ANOVA and the Post Hoc Games Howell Test. The results showed that the yellow kepok banana extract formula had the potential for wound healing. The 20 % extract formula can accelerate wound healing in a day than the 10 and 15 % formulas. The  speed  is  shown  by  wound  healing  without  scars  from  the   20 % extract formula, which  occurs  earlier  than other formulas. The anti-inflammatory activity of the 20 % formula was comparable to the positive control of commercial ointment. The anti-inflammatory activity of the yellow kepok banana ointment formula is related to the compound of saponins, flavonoids, and tannins. The results indicate that the yellow kepok banana corm extract has the potential to be developed as an anti-inflammatory drug.
STRATEGI PENGEMBANGAN RANTAI PASOK KENTANG BERKELANJUTAN DI KABUPATEN MAGETAN
Authors: Hidayati Arum , Irianto Heru , Kusnandar NFN
Published: April 2020

English
The accelerating demand growth as reflected by significant increase of potato consumption per capita indicates high potential of potato development in Indonesia. Potato production in Magetan Regency in recent years, however, has been fluctuating, perhaps due to some weaknesses in its supply chains. The objective of this study, therefore, is to formulate a sustainable supply chain development strategy for potato in Magetan Regency. The study was conducted using the Sustainable Supply Chain Management perspective and the Analytical Network Process. The study was conducted in 2016. The results show that development of sustainable supply chain is the key for accelerating and stabilization of potato production growth. Although the economic dimension is the highest priority, the social and environmental dimensions are almost equally important as well. While varietal and technological choice should be based on the highest profit, it nevertheless should also be socially acceptable and environmentally friendly, such as the Granola variety in Magetan Regency. The priority actors are farmers, government, and traders (collectors and wholesalers). The priority strategic action programs are increasing potato farming product quality and productivity, increasing potato value added, and empowering of farmers and farmers’ groups.
Keywords:  

Indonesian
Akselerasi pertumbuhan permintaan yang dicerminkan oleh peningkatan nyata konsumsi per kapita mengindikasikan bahwa kentang berpotensi besar untuk dikembangkan di Indonesia. Namun demikian, produksi kentang di Kabupaten Magetan dalam beberapa tahun terakhir ternyata berfluktuasi yang ditengarai akibat dari beberapa kelamahan pada rantai pasok. Sejalan dengan itu, penelitian ini bertujuan untuk merumuskan strategi pengembangan kinerja rantai pasok berkelanjutan untuk kentang di Kabupaten Magetan. Penelitian dilakukan dengan perspektif Sustainable Supply Chain Management dan metode analisis the Analytical Network Process. Penelitian dilakukan pada 2016. Penelitian menunjukkan bahwa pengembangan rantai pasok berkelanjutan adalah kunci untuk akselerasi dan stabilisasi produksi. Dimensi ekonomi merupakan prioritas utama, namun dimensi sosial dan lingkungan hampir sama pentingnya. Pemilihan varietas atau teknologi didasarkan pada keuntungan terbesar, namun juga diterima secara sosial dan ramah lingkungan, seperti varietas Granola di Kabupaten Magetan. Aktor terpenting ialah petani, pemerintah, dan pedagang (pengumpul dan pedagang besar). Program aksi strategis diprioritaskan pada peningkatan kualitas dan produktivitas usaha tani, peningkatan nilai tambah kentang, serta pemberdayaan petani dan kelompok tani.
Management of initial colonisations with Burkholderia species in France, a retrospective analysis in five Cystic Fibrosis Centres
Authors: Gruzelle Vianney , Guet-Revillet Hélène , Segonds Christine , Bui Stéphanie , Macey Julie , Chiron Raphael , Michelet Marine , Murris-Espin Marlène , Mittaine Marie
Published: April 2020

Whereas Burkholderia infections are recognized to impair prognosis in cystic fibrosis (CF) patients, there is no recommendation to date for early eradication therapy. The aim of our study was to analyse the current management of initial colonisations with Burkholderia cepacia complex (BCC) or B. gladioli in French CF Centres and its impact on bacterial clearance and clinical outcome. We performed a retrospective review of the primary colonisations (PC) observed between 2010 and 2018 in five CF Centres. Treatment regimens, microbiological and clinical data were collected. Seventeen patients (14 with BCC, and 3 with B. gladioli) were included. Eradication therapy, using heterogeneous combinations of intravenous, oral or nebulised antibiotics, was attempted in 11 patients. Six out of the 11 treated patients, and 4 out of the 6 untreated patients cleared the bacterium. Though not statistically significant, higher FEV1 and FVC at PC and consistency of treatment with in vitro antibiotic susceptibility tended to be associated with eradication. Thus, the management of PC was shown to be heterogeneous, and the statistic power of our study insufficient. Large prospective studies are needed to define who to treat, when, and how. Pending these studies, we propose, due to possible spontaneous clearance, to check the presence of Burkholderia one month after PC before starting antibiotics, at least in the milder cases, and to evaluate a combination of IV beta-lactam + oral or IV fluoroquinolone + inhaled aminoglycoside.
Contrast-enhanced transrectal ultrasound can reduce collection of unnecessary biopsies when diagnosing prostate cancer and is predictive of biochemical recurrence following a radical prostatectomy in patients with localized prostate cancer
Authors: Zhao Hong-wei , Li Jian , Cao Jia-Zheng , Lin Juan , Wang Zhu , Lv Jian-yao , Wei Jin-huan , Chen Zhen-hua , Yao Hao-hua , Pan Yi-hui , Gao Zhen-li , Luo Jun-hang , Chen Wei , Shi Lei , Fang Yong
Published: April 2020

Background: To investigate the value of using contrast-enhanced transrectal ultrasound (CETRUS) to reduce unnecessary collection of biopsies during prostate cancer diagnosis and its utility in predicting biochemical recurrence in patients with localized prostate cancer. Methods: This was a prospective study of suspected prostate cancer patients who were evaluated with CETRUS followed by a prostate biopsy. Prostate blood flow via CETRUS was graded using a 5-point scale. The relationship between CETRUS score and biopsy outcome was then analyzed for all patients; univariate and multi-variate analyses were used to determine the probable prognostic factors for biochemical recurrence in patients with localized prostate cancer that underwent a radical prostatectomy. Results: A total of 347 patients were enrolled in the study. Prostate cancer was found in 164 patients. A significant positive correlation (r = 0.69, p < 0.001) was found between CETRUS scores and prostate cancer incidence. Using CETRUS scores ≥ 2 as the threshold for when to biopsy could have safely reduced the number of biopsies taken overall by 12.1% (42/347) and spared 23.0% (42/183) of patients from undergoing an unnecessary biopsy. 77 patients with localized prostate cancer underwent a radical prostatectomy. The median follow-up time was 30 months (range: 8-56 months) and 17 of these 77 patients exhibited biochemical recurrence during the follow-up period. 3-year biochemical recurrence-free survival rates were 86% for patients with low CETRUS scores (≤ 3) and 59% for patients with high scores (> 3; p = 0.015). Multivariate Cox regression analysis indicated that CETRUS score was an independent predictor of biochemical recurrence (HR: 7.02; 95% CI: 2.00-24.69; p = 0.002). Conclusions: CETRUS scores may be a useful tool for reducing the collection unnecessary biopsy samples during prostate cancer diagnosis and are predictive of biochemical recurrence in patients with localized prostate cancer following a radical prostatectomy.
Potential contributions of an on-site nurse mentoring program on neonatal mortality reductions in rural Karnataka state, South India: evidence from repeat community cross-sectional surveys
Authors: Ramesh B.M. , Kar Arin , Jayanna Krishnamurthy , Hallad Jyoti S. , Troy Cunningham , Potty Rajaram , Mohan H L , Crockett Maryanne , Bradley Janet , Fischer Elizabeth , Sudarshan H , Blanchard James , Moses Stephen , Avery Lisa
Published: April 2020

Background: We assessed the effects of a nurse mentoring program on neonatal mortality in eight districts in India.Methods: From 2012 to 2015, nurse mentors supported improvements in critical MNCH-related practices among health providers at primary health centres (PHCs) in northern Karnataka, South India. Baseline (n=5,240) and endline (n=5,154) surveys of randomly selected ever-married women were conducted. Neonatal mortality rates (NMR) among the last live-born children in the three years prior to each survey delivered in NM and non-NM-supported facilities were calculated and compared using survival analysis and cumulative hazard function. Mortality rates on days 1, 2-7 and 8-28 post-partum were compared. Cox survival regression analysis measured the adjusted effect on neonatal mortality of delivering in a nurse mentor supported facility. Results: Overall, neonatal mortality rate in the three years preceding the baseline and endline surveys was 30.5 (95% CI 24.3-38.4) and 21.6 (95% CI 16.3-28.7) respectively. There was a substantial decline in neonatal mortality between the survey rounds among children delivered in PHCs supported by NM: 29.4 (95% CI 18.1-47.5) vs. 9.3 (95% CI 3.9-22.3) (p=0.09). No significant declines in neonatal mortality rate were observed among children delivered in other facilities or at home. In regression analysis, among children born in nurse mentor supported facilities, the estimated hazard ratio at endline was significantly lower compared with baseline (HR: 0.23, 95% CI: 0.06-0.82, p=0.02).Conclusion: The nurse mentoring program was associated with a substantial reduction in neonatal mortality. Further research is warranted to delineate whether this may be an effective strategy for reducing NMR in resource-poor settings.
Nausea, vomiting and poor appetite during pregnancy and adverse birth outcomes in rural Nepal: an observational cohort study
Authors: Wallin Amanda Regodón , Tielsch James M , Khatry Subarna K , Mullany Luke C , Englund Janet A , Chu Helen , LeClerq Steven C , Katz Joanne
Published: April 2020

Background Nausea and vomiting are experienced by a majority of pregnant women worldwide. Previous studies have yielded conflicting results regarding their impact on birth outcomes and few studies have examined this relationship in settings with limited resources. We aimed to determine the effect of nausea, vomiting and poor appetite during pregnancy on birth outcomes in rural Nepal.Methods Observational cohort study using data collected in two randomized, community-based trials to assess the effect of influenza immunization during pregnancy on reproductive and respiratory outcomes among pregnant women and their offspring. Pregnant women in Sarlahi District, Nepal were recruited from 2011-2013. Exposure was defined as nausea, vomiting or poor appetite at any point during pregnancy and by trimester; symptoms were recorded monthly throughout pregnancy. Adverse outcomes were low birth weight (LBW), preterm birth and small for gestational age (SGA). Adjusted relative risks (aRR) with 95% CIs is reported from Poisson regressions with robust variance.Results Among 3,623 pregnant women, the cumulative incidence of nausea, vomiting or poor appetite was 49.5% (n=1793) throughout pregnancy and 60.6% (n=731) in the first trimester. Significantly higher aRRs of LBW and SGA were observed among women experiencing symptoms during pregnancy as compared to symptom free women (LBW: aRR 1.20; 95% CI 1.05 1.28; SGA: aRR 1.16; 95% CI 1.05 1.28). Symptoms in the first trimester were not significantly associated with any of the outcomes. In the second trimester, we observed significantly higher aRRs for LBW and SGA (LBW: aRR 1.17; 95% CI 1.01 1.36; SGA: aRR 1.16; 95% CI 1.05 1.29) and a significantly lower aRR for preterm birth (aRR 0.75; 95% CI 0.59 0.96). In the third trimester, we observed significantly higher aRRs for LBW and SGA (LBW: aRR 1.20; 95% CI 1.01 1.43; SGA: aRR 1.14; 95% CI 1.01 1.29).Conclusions Symptoms of nausea, vomiting or poor appetite during pregnancy are associated with LBW, SGA and preterm birth in a setting with limited resources, especially beyond the first trimester.Trial registration ClinicalTrials.gov number (NCT01034254)