bluuebunny/crossref_metadata_2025 huggingface dataset:
INTENSITY OF FREE RADICAL PROCESSES AND STRUCTURAL-DYNAMIC PARAMETERS OF ERYTHROCYTE MEMBRANES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Authors: R.A. Khalilov , A.M. Dzhafarova
Published: February 2023

The World Health Organization has recognized diabetes mellitus (DM) as one of the four major noncommunicable diseases that lead to early disability and mortality among the population. Oxidative stress, which contributes to the intensification of free radical processes (FRP), can be considered as a universal nonspecific mechanism of DM2 pathogenesis. De-spite numerous studies, questions about the mechanisms of development of oxidative stress and its influence on the physicochemical state of biological membranes still remain open. The aim of this work is to study the intensity of free radical processes and the structural and dynamic characteristics of blood erythrocyte membranes in patients with type 2 diabetes mellitus (DM2). The study included male patients with type 2 diabetes aged 55 to 70 years who did not have other acute and chronic diseases in the acute stage. The content of glucose, glycated hemoglobin, markers of oxidative stress (MDA and carbonyl groups) was determined in the blood of patients. The structural and dynamic parameters of erythrocyte membranes were determined using fluorescent probe pyrene. It was found that an increase in blood glucose levels in patients with DM2 increases the content of markers of lipid peroxidation (MDA) and oxidative modification of proteins (carbonyl groups). Oxidative damage to lipids and proteins of erythrocyte membranes in decompensated DM2 changes their structural and dynamic properties: they increase the microviscosity of the lipid bilayer and the polarity of its phospholipids, and promote conformational rearrangements in membrane proteins. Close correlations were found between the level of glucose, the content of CRP products in the blood, and the structural and dynamic parameters of erythrocyte membrane
ANALYSIS OF THE PHARMACEUTICAL MARKET OF MEDICINAL PRODUCTS FOR THE TREATMENT OF DIABETES MELLITUS IN THE REPUBLIC OF NORTH OSSETIA – ALANIA
Authors: E.V. Morozova , A.A. Toguzova , G.D. Morozova
Published: February 2023

Relevance: pain syndrome is a common phenomenon in oncopediatrics, and pain control and proper treatment tactics remain relevant to date. Objective: to generalize the experience of approaches to the therapy of psychogenic pain syndrome in children and adolescents with oncological and oncohematological diseases at the stage of antitumor treatment. Methods: traditional clinical and psychopathological, clinical and catamnestic methods and scale methods were used for psychiatry. Research material: children and adolescents who were treated at the Research Institute of the Russian Scientific Research Center and the Oncological and Oncohematological departments of the Morozovskaya DGKB DZM in 2020-2022. Results: 32 patients were selected from all those examined with suspected psychogenic pain, whose pain syndrome corresponded to the concept of "psychogenic algic syndrome". It was noted that female patients prevailed among patients with psychogenic pain.The patients were characterized by an exaggerated description and perception of pain sensations, the intensity of pain was associated with an emotional background, current events. Typical for patients were personality accentuations, as well as such psychopathological manifestations as anxiety, reduced mood background, fears, hypochondriac fixation. The proposed treatment tactics included medical (medicinal) and non-medical methods (psychotherapy, work with parents and caring adults). Conclusions:integrative models of therapy (a combination of medicinal and non-medicinal methods) for psychogenic pain syndrome show their high effectiveness.
INDIVIDUAL ORAL HYGIENE PROTOCOLS FOR DENTAL IMPLANTATION
Authors: V.R. Shashmurina , G.V. Volchenkova , E.A. Mishutin
Published: February 2023

Aim. Improving the quality of treatment of patients with defects in the dentition using orthopedic structures based on dental implants with development of individual oral hygiene protocols. Materials and methods. A survey of 82 patients using prostheses fixed on intraosseous dental implants was carried out. The results of treatment 5 years after the installation of implants were analyzed according to the criteria: the quality of oral hygiene and the presence of inflammation in the tissues surrounding the implant. Results. After fixation of prostheses based on dental implants, 73.2% of patients do not follow the recommendations on the oral care. Satisfactory level of oral hygiene in 57.3%, unsatisfactory - in 28.0% of patients using a manual toothbrush. The number of "successful" implants after 5 years is 41.5%, removed - 7.3%. Tissue inflammation was found in 36.5% of implants. Protocols for individual oral hygiene of patients using a toothbrush have been developed: before implantation; after surgery implantation early period; after implantation surgery late period; after completion of implant-supported prosthetics. Conclusions. The use of the toothbrush in the treatment of patients before and after dental implantation is a promising direction in improving its immediate and long-term results. The interactive functions of electric toothbrushes are considered as a tool for motivation and control of oral hygiene. The functionality of the toothbrush greatly simplifies hygienic care in hard-to-reach areas of dentures. The presence of seven modes and two nozzles helps to provide individual approach to oral hygiene, depending on the condition of the tissues.
ASSESSMENT OF THE LEVEL OF SALES CONCENTRATION IN THE FRAMEWORK OF THE DEVELOPMENT OF STRATEGIC DECISIONS IN THE FIELD OF PRICING FOR DRUGS
Authors: A.S. Orlov
Published: February 2023

The article considers the problem of assessing the level of concentration of market sales, which arises in the process of developing and implementing strategic decisions in the field of pricing in the pharmaceutical market. Information about the level of concentration of sales in the market and the type of market structure demonstrates a certain degree of freedom that can be enjoyed in the process of pricing medicines. The methodology for determining, the advantages and disadvantages of the concentration index and the Herfindahl-Hirschman index, which are currently mainly used in practice to quantify the level of sales concentration in the market, is presented. The results of calculating the concentration index and the Herfindahl-Hirschman index to assess the concentration of sales in two segments of the Russian pharmaceutical market, including antimicrobial ophthalmic drugs, as well as antiglaucoma drugs and miotics, are presented. It is shown that in order to obtain an objective assessment of the level of sales concentration, a comprehensive analysis of the market is required, based on the calculation of additional concentration indicators, which include the relative entropy index, the Rosenbluth index, and the dispersion of market share logarithms. A detailed description of the advantages and disadvantages of the sales concentration indicators proposed for use and the possibilities of their application in the pharmaceutical market is given. On the example of two selected segments of the Russian market of ophthalmic drugs, it is demonstrated that the calculation of five concentration indicators and the interpretation of the data obtained are necessary conditions for obtaining an objective assessment of the competitive situation and, as a result, making informed strategic decisions in the field of drug pricing.
EXPERIENCE IN THE TREATMENT OF PATIENTS WITH COMPLETE ABSENCE OF TEETH USING TWO DENTAL IMPLANTS
Authors: L.I. Nikitina , V.V. Gilyazeva , A.S. Gromova
Published: February 2023

Despite the advances in modern dentistry, a steady increase in the number of patients with complete absence of teeth continues. From 30 to 70% of people need to make removable dentures. This is due to the imperfection of technologies, designs of dentures and materials for their manufacture, changing clinical conditions. The leading cause of clinical failure is poor stabilization of removable dentures on the jaws. In this regard, increasing the effectiveness of prosthetics in the absence of teeth is an urgent problem in modern dentistry. The article presents the experience of treating patients aged 60-75 years with a complete absence of teeth using two dental implants, a conditionally removable prosthesis, mechanical fasteners, and a spherical abutment. Implants of the systems Astra Tech, Nobel Biocare, Mis. We examined 33 patients aged 60-75 years, including 20 women and 13 men, with complete absence of teeth. 10 patients in the control group were made complete removable lamellar dentures. In 23 patients with severe atrophy of the alveolar processes, two dental implants were installed, followed by prosthetics according to the All-on-2 protocol. The follow-up period was 11 years. The data of the results of the observation indicated that in the control group, poor stabilization of the removable denture was registered, in three cases - its breakdown, in two patients, lesions of the oral mucosa were detected. In patients with dental implants, successful stabilization of removable dentures was noted with the preservation of the function of chewing, speech production and all articulatory relationships without damage to the oral mucosa.
THE POSSIBILITIES OF ULTRASOUND DIAGNOSTICS IN THE PROGNOSTIC ASSESSMENT OF THE EPICARDIAL ADIPOSE TISSUE THICKNESS IN CARDIOVASCULAR PATHOLOGY
Authors: T.A. Mischenko , T.N. Vasilkova
Published: February 2023

Recent studies have shown that different visceral fat depots can make a special contribution in development of endocrine and cardiovascular diseases. Epicardial adipose tissue (EAT) is a unique visceral fat depot, closely anatomically and physiologically related to the myocardium. This visceral fat depot has a transcriptome and secret that are very different from fat depots of other localizations. In healthy individuals, the EAT performs a buffer and cardioprotective function, but with the development of pathology, the EAT begins to secrete pro-inflammatory factors, and the synthesis of anti-inflammatory cytokines decreases. This fact is confirmed by numerous studies. A promising area of modern cardiology is the study of the prognostic value of epicardial fat in assessing the risk of cardiovascular disasters and survival of patients with various comorbid conditions. It has been proven, that people even with a normal body mass index have a risk of cardiovascular diseases and complications. People with normal body weight and the presence of visceral obesity have the cardiovascular risk in 2.75 higher, and the risk of death from all causes in 2.08 higher than in people with normal body weight without visceral obesity. Thus, only the use of anthropometric examination methods in practice may be insufficient for the diagnosis of visceral obesity. The most affordable, reproducible, cost-effective method of visualization of epicardial fat in clinic is echocardiography doppler methods. This review is devoted to the possibilities of using ultrasound diagnostics in the assessment of epicardial fat, as well as the possibility of improving the stratification of cardiovascular and metabolic risks based on an additional analysis of the epicardial fat thickness.
FEATURES OF THE MANIFESTATION OF AGEISM AND MEASURES TO ELIMINATE THEM IN THE REPRESENTATIVES OF THE YOUNGER GENERATION
Authors: A.A. Melnichenko , S.G. Gorelik , V.M. Stadnichenko , A.C. Yarosh
Published: February 2023

The relevance of the topic of the article lies in the fact that there is age discrimination of older people, which raises the question of the quality of life of the elderly population. The purpose of the article is to consider the types of ageism, its causes, and measures to eliminate them in the representatives of the younger generation. The research materials were scientific articles and websites of well-known organizations. Research methods: study of various sources of information, analysis of the information obtained, synthesis, deduction, induction. The results of the study. The article describes the types of ageism, such as open ageism, latent ageism, everyday ageism, self-ageism. The main causes of ageism are noted. These include gerontophobia, negative stereotypes, declining status of the elderly, low culture in society, lack of geriatrics and gerontology programs in full, insufficiently qualified personnel in the field of health care, social services. Measures to eliminate manifestations of ageism among the younger generation should include the use of various media, the development and monitoring of gerontological ageism in medical centers and social institutions, the audit of clinical, managerial, strategic and financial documents defining age restrictions for access to treatment, medicines or services, the formation of social and medical employees, as well as future specialists studying in these specialties, skills of self-reflection of attitudes towards aging and the elderly, increasing the competence of social and medical workers in the field of geriatrics and gerontology through appropriate courses. In conclusion, it is concluded that the state policy should be aimed at expanding legislation, writing various projects and programs about older people that will help overcome poor awareness of this issue and change negative stereotypes about aging to positive ones. Efforts should be made to stimulate contacts between representatives of different generations, facilitating communication and interaction between them.
DETERMINATION OF SOME QUALITY INDICATORS OF THE LEAVES OF SANGUISÓRBA OFFICINÁLIS L.
Authors: N.V. Nesterova , M.U. Magomedova
Published: February 2023

Analyzing the modern scientific literature, the authors note the growing interest of researchers in studying the quality indicators of non-pharmacopoeial plant raw materials, the procurement of which is carried out from pharmacopoeial and food plants. Such plants are often characterized by a wide range of biologically active substances, which allows them to be considered as promising raw materials for use in medicine and pharmacy. The object of the study was the leaves of the medicinal hemophlebus (Sanguisórba officinalis L.). To determine the authenticity of raw materials, the authors conducted studies of morphological and anatomical features. The analysis of external signs was carried out in accordance with the GFA. 1.5.1.0003.15 "Leaves", the analysis of microdiagnostic signs was carried out in accordance with the requirements of the GFA.1.5.3.0003.15 "Technique of microscopic and microchemical examination of medicinal plant raw materials and medicinal plant preparations" on a medical binocular microscope MICMED 5 (uv.×40) and a Microvizor Mkvizo – 103 (uv. ×100). The appearance was determined for whole and crushed raw materials, the leaves of the hemophlebus. Whole raw materials are characterized by a complex structure of the leaf with 7-25 leaflets, while the size of the leaf blade is from 3 to 7 cm long, from 2 to 4 cm wide. The raw material of the hemophlebone is characterized by an unpaired and oblong-ovate shape of the leaf blade with a heart-shaped base. The edge of the leaf blade is pointed or serrated. The venation of the leaf is pinnate. There is a petiole, the length of which is from 1.5 to 3 cm, diameter: from 1 to 2 mm. The petiole is characterized by a developed ribbed surface and the presence of a vagina and stipules, the length of which is from 0.5 to 1.5 cm. The absence of pubescence is characteristic for both the leaf blade of the hemophlebus and the petiole. Leaf color: the upper part is shiny dark green, and the lower part is dull bluish-green. The smell is pleasant cucumber, specific, astringent taste, characteristic external signs were identified that allow identifying raw materials. When studying the microscopic features of the raw materials of the hemoptysis, diagnostically significant signs were established that allow us to establish authenticity indicators, represented by the features of the structure of the epidermis with sinuous thickened walls, the anomocytic type of the structure of the stomatal complex, the presence of receptacles with yellow contents, trichomes represented by simple and glabrous hairs, as well as calcium oxalate druses concentrated mainly along the veins.
ONE-YEAR OUTCOMES IN PATIENTS WITH CORONARY HEART DISEASE WITH PROGRESSIVE ATHEROSCLEROSIS
Authors: O.M. Parkhomenko , N.G. Lozhkina , Kh.M. Bataev
Published: February 2023

Вackground. Progressive atherosclerosis syndrome, in contrast to spontaneous one, is accompanied by a more severe course and frequent complications. Therefore, it is crucial to define the risk stratification criteria and treatment of such patients.
Purpose of the study to study one-year outcomes in patients with coronary heart disease with progressive atherosclerosis.
Patient Characterization and Research Methods. The study included 202 patients with confirmed diagnosis of CHD: 147 men and 55 women. The mean age of the patients was (53,3 ± 7,16) years. The main group (100 patients) included those who had two (or more) additional cardiovascular events from the following in the two years before the study: MI or unstable angina pectoris, emergency artery stenting, stroke, peripheral artery thrombosis, critical ischemia or lower limb amputation, and the comparison group included 102 patients with CHD without such events. After 12 months from the time of inclusion, end points were evaluated. Statistical Analysis Methods. Microsoft Office Excel 2019 program was used.
Results. The work revealed that patients with progressive atherosclerosis have worse long-term (one-year) prognosis in comparison with its spontaneous course; a significant influence on unfavorable outcomes is exerted by: Angina of any EF without surgical treatment - OR 4.125 (1.213; 14.027), multivessel coronary artery disease - OR 3.929, CI (1.156-13.350), C-reactive protein level 5 mg/L or higher - OR 18.667, CI (4.684-74.393).
TOPICAL QUESTIONS OF ASSESSING THE QUALITY OF A POLYCOMPONENT REPARATIVE GEL
Authors: E.B. Nikiforova , K.I. Melkonyan , D.V. Veselova , A.G. Nechaeva , Y.A. Kozmai , T.V. Rusinova
Published: February 2023

The domestic pharmaceutical market still lacks reparative drugs, which determines research on their creation as an urgent theoretical and applied task. In this regard, the expediency of developing the composition and technology for obtaining a polycomponent gel with a predictable positive effect on wound healing processes based on dermal biopolymers and a complex of biologically active substances of corn columns with stigmas is substantiated. The complex of technological studies carried out made it possible to establish the optimal composition and technology for obtaining a polycomponent gel. At the next necessary stage of pharmaceutical development, it was necessary to solve the issues of assessing the quality of the proposed composition of the polycomponent gel. The purpose of this study was to determine the criteria and methods for monitoring the quality indicators of a multicomponent reparative gel. The object of the study was experimental samples of a multicomponent gel obtained by introducing a thick extract of corn columns with stigmas into a collagen base. The quality of the polycomponent gel was assessed in accordance with the requirements of GPM.1.4.1.0008.15 "Ointments" of the State Pharmacopoeia IV edition according to the following criteria: "Description", pH, "Microbiological purity", authenticity and quantitative content of active substances. The indicator "Description" was evaluated organoleptically. The determination of the pH of the gel was carried out potentiometrically using a pH meter (Mettler Toledo, USA) according to GPM.1.2.1.0004.15 "Ionometry" directly in the gel sample. Microbiological purity was studied by the agar plate method in accordance with GPM.1.2.4.0002.15. The presence and quantitative determination of flavonoids in the developed gel was determined spectrophotometrically on a UV-1800 SHIMADZU spectrophotometer, Japan. As a result of the studies carried out, the criteria for the quality of a multicomponent gel of reparative action were studied and proposed. According to the "Description" indicator, the polycomponent gel is a homogeneous mass of light brown color with a pleasant fruity odor without impurities. It has been established that the polycomponent gel is characterized by a slightly alkaline pH value, which creates optimal conditions for the healing phase of the wound process. It is shown that the use of the method of differential spectrophotometry makes it possible to carry out a statistically significant qualitative and quantitative assessment of the content of flavonoids in the composition of a polycomponent gel.
LIPOMA AS AN ACCIDENTAL FINDING IN ABDOMINAL SURGERY
Authors: P.V. Zakharova , I.A. Mussova , M. Amiri , D.S. Kulikov , Z.S Kaitova
Published: February 2023

Primary neoplasms of the abdominal cavity are rare and usually have a mesenchymal origin. Lipoma is a benign mature tumor of adipose tissue, it occurs more often in women aged 30 to 50 years. Retroperitoneal lipoma is a rare variant of lipoma, manifested by various signs and symptoms that can mislead specialists. Lipomas are more common in abdominal surgery in the gastrointestinal tract. In this localization, the main pathognomonic complication is intestinal intussusception. Diagnosis is difficult, due to the relatively slow growth of education, characteristic clinical manifestations may be absent for a long time. X-ray imaging is the preferred diagnostic method. To date, surgical resection is the priority method of treatment of this pathology.
The analysis of scientific literature on the occurrence of abdominal lipomas is carried out. The diagnostic significance in assessing the condition and complications of lipomas has been studied. Clinical cases from personal practice on the basis of the State Clinical Hospital named after him are presented. Yudina. Patients with diagnoses of giant retroperitoneal lipoma and complicated small intestine lipoma by female intussusception aged 62 and 78 years, respectively. The first clinical case demonstrates the randomness of the determination of lipoma in a patient admitted to the clinic with a closed craniocerebral injury and a wound of the soft tissues of the head. Ultrasound of the abdominal cavity showed the presence of a large retroperitoneal formation of an inhomogeneous consistency. During laparotomy, a giant fatty tumor with clear boundaries was revealed, closely adjacent to the adipose tissue of the retroperitoneal space. Lipoma was removed, drainage of the abdominal cavity and retroperitoneal space was performed. Histopathological examination confirmed the diagnosis of retroperitoneal lipoma. The weight of the lipoma was 10.610 kg. The postoperative period proceeded without complications. The second clinical case shows how a long-term undiagnosed lipoma of the gastrointestinal tract leads to a complicated course, namely intussusception. Patient A. 78 years old with discomfort and abdominal pain during the last few weeks, small intestine invagination was detected using ultrasound. Diagnosis upon admission: acute pancreatitis. A resection of the altered section of the small intestine was performed. The postoperative period was favorable. The patient was discharged on the 10th day. The presented clinical cases of this disease once again confirm the importance of timely dispensary diagnosis of abdominal tumors.
CONTEMPORARY PERCEPTIONS OF THE POSTRODUCTION ENDOMETRY (LITERATURE REVIEW)
Authors: V.A. Linde , M.A. Levkovich , A.Yu. Havansky , B.V. Arakelyan , P.M. Palastin , A.M. Marzhevskaya , D.K. Gurtsieva
Published: February 2023

The review is based on the databases https://cyberleninka.ru/, PubMed, MedArt, and CNMB. Postpartum endometritis is the leading infectious and inflammatory disease of the postpartum period and one of the stable leading causes of maternal mortality. In Russia, the incidence of postpartum endometritis in the population is 3-8%, in pathological deliveries it is 10-20%, and in women with a high infection risk it is 13.3-54.3%. Infection occurs predominantly by the ascending route, as a rule, with active participation in associations of opportunistic pathogenic flora. The leading position among the risk factors of postpartum endometritis is taken by surgical delivery and, primarily, by cesarean section. Immune disorders play one of the key roles in the pathogenesis of this disease according to modern researchers. In case of insufficient effectiveness of empirical antibacterial therapy, the choice of antibacterial drugs must be made on the basis of blood cultures. The second local component of treatment of patients with postpartum endometritis is the evacuation of uterine cavity contents. Careful emptying is one of the most important criteria for choosing the method of evacuation. An immunomodulatory component should be included in the treatment to increase its effectiveness. Thus, postpartum endometritis is a serious obstetric problem, in the treatment of which gentle evacuation of the uterine cavity contents in combination with local use of immunomodulatory drugs is promising.
THE ROLE OF EMOTIONAL TRIGGERS IN SCREEN CULTURE
Authors: V.V. Kortunov , S.L. Grigoryev
Published: February 2023

The relevance of the research is connected with the need to explain the mechanisms and strategies of the screen's influence on modern man. The problem of emotional perception of screen culture by a person through the prism of "emotional triggers" is considered, some of their types are analyzed and examples of embedding in screen culture are given. A certain vision of the role of emotional triggers is also formulated and the prospects for further development of screen culture in which they will play a key role are described. Emotional triggers contribute to maintaining the process of endless consumption of mass culture products. The maintenance of this process occurs due to the formation of a sense of emotional closeness and deep, in the opinion of the viewer, emotional contact with the products and phenomena of modern mass culture. Triggers become a form of representation of reality in the consciousness of the subject, creating instead of real reality a new form of its representation filled with visualized images and phantoms, which brings a certain emotional load into the viewer's consciousness. In this sense, screen culture can be considered as a global tool that exerts an artificial influence on both the individual viewer and the public consciousness as a whole. Emotional triggers, influencing the thoughts and behavior of the viewer, form secondary ways of describing the world for him, set the coordinates of orientation in the world of screen culture, simulating the immediacy of personal experiences and feelings, creating the illusion of belonging, integrity to a certain informational whole, thus building their own identity. The role, or rather the power of the impact of emotional triggers in modern screen culture is due to the fact that they are always visualized, and emotions most vividly affect it through visual images.
MODELS OF HUMAN BEHAVIOR IN THE ECONOMY
Authors: E.D. Kubasova , R.V. Kubasov , V.V. Lupachev , G.V. Korelskaya
Published: February 2023

Economic psychology, as one of the directions of economic science, analyzes human behavior in society in terms of a choice between efficiency and fairness, profit and honor, needs and values, etc. The economic behavior of an individual is a complex process of choosing from a variety of alternatives in order to find the most rational or satisfactory result of activity. At the same time, external and internal factors limiting a person's choice for making such a decision are considered. An economic person is faced with the task of achieving the maximum possible result of activity in certain conditions of existence on the basis of determining a specific set of benefits, information on minimizing risks and monitoring the behavior of participants in economic activity. Choosing the optimal solution in the conditions of receiving a huge amount of information is complicated due to its change over time. At the same time, the search for new information leads to significant time expenditures, the choice of options for actions is carried out by the mechanisms of habit, tradition or routine. The behavior of individuals, their desire to maximize their own benefits to the detriment of the position of other individuals is expressed in the fact that economic entities try to minimize costs and losses by developing certain rules, norms of behavior, including coercive measures against those who violate them. The choice of the range of available alternative behaviors by the subject assumes, in general, from the point of view of the theory of adaptive rationality, two behavioral aspects. On the one hand, the subject must make decisions in the existing institutional environment, where there are prerequisites that influence the selection process. On the other hand, the subject also has the opportunity to choose not only between behaviors within the same institutional structure, but also, through real actions, to choose between different institutions. The main behavioral prerequisites of institutionalism include limited rationality, polymotivation and opportunism.
TELEMATIC ART IN TRANSHUMANISM
Authors: Yu.V. Khvastunova
Published: February 2023

This paper considers the concept of telematic art in transhumanism. In the framework of the development of transhumanistic design (the projects “Primo Posthuman” by N. Vita-More), where the ideas and methods of technological art are implemented, including the art of new media, one of the first varieties was telematic art or, more broadly, media art. Its pioneers, in particular, Roy Ascott, enthusiastically speak about the transhumanist project “human enhancement” picturing it as an opportunity to implement the potential of telematic art, taking into account the growing influence of digital and other telecommunication technologies. The paper also discusses main directions and ideas of such a convergence from the point of view of philosophy and the history of art, highlights a common component – the convergence of the gnostic interpretation of matter with the ideas of planetary consciousness, the theory of a simulated universe, the theory of emergence, and the postmodern interpretation of nature as a kind of general metaphor that has a finite shelf life and should be removed from the modern discourse as irrelevant. R. Ascott suggests abandoning the term “art” and using the term “connectivism” instead. Furthermore, the transhumanists’s arguments come down to a simple substitution, according to the principle “an irrelevant metaphor is replaced by a relevant one”, i.e. a more convenient one (the old interpretation of nature is replaced by the new concept of “nature II”, which means a radically transformed natural environment, i.e., in fact, an artificial environment). This methodological framework is connected with the fact that, according to transhumanists, only artificial life will develop in the future, so there is no place for “a natural man”. The article provides a critical analysis of possible consequences of the reduction of art to the technological sphere and serving the goals of transhumanism.
Analisis Hubungan Pengeluaran Dengan Ketahanan Pangan Rumah Tangga Petani Di Kabupaten Aceh Utara
Authors: Praza Riyandhi , Shamadiyah Nurasih
Published: February 2023

Pangsa pengeluaran pangan berhubungan terbalik dengan ketahanan pangan, semakin besar pangsa pengeluaran pangan maka semakin rendah ketahanan rumah tangga yang bersangkutan. Pendapatan merupakan salah satu faktor yang menentukan pola konsumsi rumah tangga. Pendapatan yang semakin tinggi menunjukkan daya beli semakin meningkat dan meningkat pula aksesbilitas terhadap pangan yang berkualitas lebih baik. Aceh Utara merupakan salah satu kabupaten yang potensial atas kerawanan pangan (Badan Pusat Statistik Aceh dalam angka, 2018). Mayoritas Kecamatan di Aceh Utara menjadikan sektor pertanian sebagai sumber mata pencaharian. Penelitian ini dilakukan di 3 kecamatan, yaitu Baktiya, Sawang, dan Lhoksukon dengan sampel berjumlah 60 orang petani padi sawah. Penelitian ini bertujuan untuk mengetahui: (1) mengetahui besarnya proporsi pengeluaran pangan  terhadap pengeluaran total rumah tangga petani menurut kelompok pendapatan, (2) mengetahui tingkat konsumsi pangan (energi dan protein) rumah tangga petani Utara berdasarkan strata pendapatan dan (3) menganalisis kondisi ketahanan pangan rumah tangga petani menurut kelompok pendapatan. Berdasarkan hasil penelitian di atas dari persamaan pangsa pengeluaran diperoleh persentasi ketahanan pangan rumah tangga petani di Kabupaten Aceh Utara menunjukkan bahwa rumah tangga petani yang tahan pangan sebanyak 25 petani (41,67%) dari total sample penelitian. Selanjutnya, diperoleh rumah tangga petani dengan kategori kurang pangan sebanyak 1 petani (1,67%), rumah tangga petani dengan kategori rentan pangan sebanyak 2 petani (3,33%), dan rumah tangga petani dengan kategori rawan pangan sebanyak 32 petani (53,33%) dari total sample penelitian. Hasil penelitian menunjukkan bahwa petani yang memiliki pendapatan rendah berada dalam kategori rawan pangan.
The Effect of Additional Compensation on Employee Performance Mediated by Job Satisfaction of Employees of PT Telkom Indonesia Tbk.
Authors: Khair Hazmanan , Adira Luthfiah
Published: February 2023

The purpose of this research is to determine the effect of additional compensation on employee performance at PT Telkom Indonesia, Tbk Witel Medan. To determine the effect of job satisfaction and employee performance on additional compensation at PT. Telkom Indonesia, Tbk Witel Medan. To determine the effect of job satisfaction on employee performance at PT Telkom Indonesia, Tbk Witel Medan. To determine the effect of additional compensation and employee performance on job satisfaction at PT Telkom Indonesia, Tbk Witel Medan. The approach in this research is included in the quantitative research approach. The population used as a sample is all employees of PT Telkom Indonesia, Tbk Witel Medan, totalling 70 people. The data analysis technique in this study uses Structural Equational Modelling (SEM) using Smart-PLS 3. The results of testing the first hypothesis show that the additional compensation variable has a positive and significant effect on employee performance at PT Telkom. The results of testing the third hypothesis show that the additional compensation variable has a positive and significant effect on employee job satisfaction at PT Telkom. The results of testing the fifth hypothesis show that the job satisfaction variable has a positive and significant effect on employee performance at PT Telkom. The results of the sixth test show that employee job satisfaction mediates the effect of additional compensation on performance at PT Telkom by showing a positive but insignificant effect.
Null Effects of Framing Welcoming Ordinances
Authors: Doherty David , Garbarski Dana , Rivera Pablo Guzman
Published: February 2023

A substantial body of published work finds that seemingly trivial changes in question wording or the way an issue is framed can substantially affect the attitudes people report on surveys. We report findings from a survey of Cook County residents where seemingly strong issue framing treatments that varied the stated purpose of welcoming ordinance provisions failed to affect reported attitudes. We find no effect in the aggregate, nor do we find effects among demographic or other seemingly relevant subgroups. The findings illustrate the important but often overlooked fact that varying how an issue is framed does not always affect reported attitudes.
EKPHRASTIC POETRY AND INDIAN MINIATURE PAINTINGS: ARTISTRY AND AESTHETICS OF DEBASISH LAHIRI’S TETHER THAT LIGHT
Authors: Mukherjee Pradipta
Published: February 2023

For an internationally acclaimed Indian English poet, Debasish Lahiri, time is a recording of the lingering of light, in nature, in the mind. His recent collection of poems, Tether that Light (2022) is an attempt to follow that trail of light left in selected Indian miniature paintings, particularly Mughal, Rajasthani, Pahari, and Deccani paintings. The intricate artworks and enchanting visuals of these incredible canvases have enthralled the poet who uses the treasure trove of Indian miniatures that work as intertexts for his ekphrastic collection of poems. Given the pictorial effect of words appearing as miniature paintings, the flawless transformation from one medium to the other, Lahiri’s symbiosis between literary texts and performing arts, poetry, and painting, foregrounds how concepts, attitudes, and ideologies operate across a broader cultural spectrum that is not exclusively literary. Transcending the borders of time and space, Tether that Light not only makes way for a larger interdisciplinarity between sister arts but opens up new avenues for interrogating notions of historicity, textuality and appropriations.
समकालीन भारतीय जलरंग चित्रकारों द्वारा समाज का चित्रण़
Authors: Bala Rajni , Viranjan Ram
Published: February 2023

किसी देश की संस्कृति स्वयं को धर्म, दर्शन, साहित्य, संगीत, स्थापत्य एवं कला के रूप में अभिव्यक्त करती है। प्राचीन काल से ही भारतीय संस्कृति को बनाए रखने में भारतीय कलाओं ने महत्वपूर्ण योगदान दिया है। कला की अपनी एक भाषा होती है, जिसका प्रयोग चित्रकार समाज के लक्ष्यों की पूर्ति के लिए करता है, जो समाज को प्रभावित करती है। कला का आरम्भ भी मानवीय विकास के साथ हुआ तथा निरंतर चलता रहा है। प्राचीन प्रागैतिहासिक काल से लेकर आज की कला और समाज के अनोखे संबंध को समझाया गया है। जिसमें सामाजिक व्यवस्था तथा कलात्मकता का विचित्र समावेश हमारे सामने आत्मसात् किया गया है। समाज के विभिन्न रीति-रिवाज कला पर आधारित होते है। कलाएँ समाजिक तथ्यों के प्रति सदैव उत्तरदायी रही है। कला और समाज का परस्पर गहरा और आन्तरिक सम्बंध है और कला इसका अभिन्न अंग है। समाज के द्वारा हीं कला का जन्म होता है तथा कला का विकास इसके अन्तर्गत रहने वाले कलाकारों के सृजनात्मक कलाकृतियों के माध्यम से होता है। भारतीय कलाकारों ने अपनी कला का विस्तार करने के लिए अनेक माध्यमों को अपनाया है। कला में कल्पना को साकार करने के लिए अलग-अलग माध्यम एवं सामग्री का प्रयोग किया जाता है, जिनमें से जलरंग एक प्रमुख माध्यम है। जलरंग एक ऐसा माध्यम है, जिसमें पारदर्शिता का गुण दिखाई देता है। इस पद्धति से कलाकार चित्रांकन के द्वारा कला को समाज के निकट लाने का प्रयत्न कर रहा है। जलरंग पद्धति से चित्रकारों ने समाज में व्याप्त सामाजिक, राजनीतिक, आर्थिक परिस्थितियों को उजागर कर समाज को सत्य के दर्शन कराने में महत्वपूर्ण भूमिका निभा रहा है, जिनमें से आधुनिक और समकालीन कलाकार अवनींद्रनाथ टैगोर, गगनेंद्रनाथ टैगोर, गणेश पाइन, वासुदेव कामथ, समीर मंडल, राजकुमार स्थापति, राम जैसवाल, रघुनाथ साहु और प्रभु जोशी आदि।
Nitroselüloz Bazlı Yakıtların Depolama Ömürlerine Ortam Koşullarının Etkisinin İncelenmesi
Authors: ÇAĞLAYAN Mehmet , PUL Muharrem , METİN Ayşegül Ülkü
Published: February 2023

Bu çalışmanın konusu olan mühimmatlara ait yakıtlar her türlü iklim koşullarına (titreşim, alçak ve yüksek rakım, hava araçlarında yüksek irtifa, aşırı sıcaklık, nem vb.) maruz kalmaktadır. Bu sebeple üretim sonrası verilen depolama ömrünü daha kısa sürede tamamlamakta ve kendiliğinden infilak edebilmektedir. Bu maksatla çift bazlı yakıtın maruz kaldığı çevresel etkileri simüle edilebilmesi için üç farklı sıcaklıkta (60C-70C-80C) ve %60 nem koşulları sağlanarak hızlı yaşlandırma işlemi uygulanmıştır. Yaşlandırma işlemi tamamlanan yakıtın fiziksel ve kimyasal değişimleri gözlemlenerek çeşitli testler uygulanmıştır. Stabilizör miktarı tayini testi sonucunda stabilizör miktarının minimum % 0,2 w/w değerinin altına düştüğü, hızlı yaşlanma etkisi ile stabilizör miktarının azaldığı gözlenmiştir. Nem tayini testinde nem miktarının maksimum %0,6 değerini aşmadığı, kalori değeri ölçümü testinde kalori değerinin 836-864 cal/g değerleri arasında kaldığı, ısı akış kalorimetresi (HFC) ile yapılan kararlılık testinde ısı akış miktarının maksimum 114 µw/g değerini aşmadığı gözlemlenmiştir. SEM mikroskobu ile yakıtların yapısı görüntülenerek doğal yaşlanma ve hızlı yaşlandırma işlemleri sonrasında yakıtta meydana gelen değişimler gözlenmiştir. FTIR spektrumları alınarak doğal yaşlanmış ve hızlı yaşlandırılmış yakıt içinde meydana gelen kimyasal değişimler incelenmiştir.
İş Değerlendirme Sürecinde Çok Kriterli Karar Verme Teknikleri Üzerine Bir Uygulama
Authors: OLCAY Ataberk , DÜĞENCİ Muharrem , İPEK Mümtaz , TÜRKOĞLU ELİTAŞ Medine Nur
Published: February 2023

İş değerlendirme; işletmelerdeki performans değerlendirme ve ücret yönetimine girdi oluşturmak amacıyla işlerin maharet, sorumluluk, iş koşulları vb. gibi faktörler çerçevesinde değerlendirilerek biçimsel ve sistematik olarak karşılaştırılmasıdır. Bu çalışmada Demir Çelik Sektörü’ne faaliyet gösteren bir işletmenin çelik üretim müdürlüğü birimindeki mevcut 48 adet mavi yaka işçilik pozisyonları değerlendirilmiştir. Öncelikle AHP yöntemi ile ikili karşılaştırma matrisleri oluşturulmuştur. Bunun sonucunda 48 adet mavi yaka işçilik pozisyonuna ait yakınlık katsayıları hesaplanarak sıralama elde edilmiştir. Topsis ve Bulanık Topsis sonucu ortaya çıkan işçilik pozisyonlarına ait puanlar; Ünite Amiri, Şef ve ilgili kısımdaki Formenin görüş ve kararı doğrultusunda puanlanan işçilik pozisyonlarının sıralaması ile karşılaştırılmıştır. Bu amaca uygun olarak da hedef, yapılan iş değerlendirme sonucu ortaya çıkan işlerin önem düzeyi ve sıralaması doğrultusunda, o işe uygun çalışanların belirlenmesi ve çalışanların performanslarının değerlendirilerek, proseste yapılabilecek olan iyileştirme çalışmalarının şirkete tavsiye olarak verilmesidir.
A Novel Design of Constant Load Creep Test Machine
Authors: DEMİR Hasan , COŞGUN Atıl Emre
Published: February 2023

Polymer materials have been used in a wide area from our homes to industry today. For this reason, creep curves from the mechanical properties of polymer materials are an important factor for the correct use of polymers. This article presents a new constant load creep test machine design which is a mechatronic system to perform creep testing of polymers. A low-cost creep test machine was developed by mounting clamps, pulleys, weights and steel cable on top of a main frame. With the measurement unit, the linear movement of the steel cable was detected and recorded with the data logging system together with the ambient temperature. Tests were made with a 15% calcium carbonate reinforced polypropylene specimen. It was observed that the experimental data obtained were compatible with a standard creep test curve. These findings confirm that the presented constant load creep test machine design works efficiently.
Investigation of Energy Metabolism in The Different Tissues of Colon Cancer Xenograft Models Based on The TCA and Cori Cycles and Glycolysis
Authors: BULUT ATALAY Esra , AYAR KAYALI Hülya
Published: February 2023

The metabolism is reprogrammed in cancer cells to meet the requirement of their malignant properties. Some specific metabolites can contribute to the malignant transformation in different cancer types. This study aimed to determine the level of glucose, pyruvate, lactate, citrate, alpha-ketoglutarate (α-KG), 2-hydroxyglutarate (2-HG), succinate, fumarate, malate, and oxaloacetate in the different tissues (tumor, colon, brain, and liver) of xenograft models generated by a colon adenocarcinoma cell line (SW480). Glucose and pyruvate levels were determined by the 3,5-dinitrosalicylic acid (DNS) method and pyruvate assay, respectively. The level of other metabolites was determined by the HPLC analysis. The results show that D-2-HG is highly produced in the tumor tissues (120.2 mg/L), but it could not be detected in liver tissue. In conclusion, TCA and Cori cycles and Glycolysis were investigated in the different tissues of colon cancer xenograft models and found that some metabolites produced tissue-specific.
Hidrofobik Kaplamanın Kanat Profillerinin Aerodinamik Parametrelerine Etkisinin Deneysel İncelenmesi
Authors: ŞAHİN Fevzi , İSMAİLOV İsmayil , ÖZCAN Hakan
Published: February 2023

Bu çalışmada NACA 4418 kanat profile üzerinde deneysel bir çalışma yürütülmüştür. Kanat profili spray kaplama yöntemi ile iki farklı malzeme ile kaplanmış, ıslanırlık derecesi (su damlasının yüzey ile temas açısı, θ) belirlenmiştir. Normal (θ=59o90o) ve süperhidrofobik (θ=154o>150o) olmak üzere üç farklı kanat profile yüzeyi elde edilmiştir. Bu üç farklı durum için, kaldırma ve sürüklenme katsayıları, 15 m/s (Re=253.196) serbest akım hızında ve 6 farklı hücum açısında (-10°, -5°, 0°, 5°, 10°, 15°) rüzgar tünelinde deneysel olarak belirlenerek birbiriyle karşılaştırılmıştır. Sonuçlar, normal (hidrofilik) kanat profiline, hidrofobik ve süperhidrofobik özellik kazandırılmasının kanat profilinin kaldırma katsayılarını tüm hücum açıları dikkate alındığında sırasıyla ortalama %15 ve %23 oranında iyileştirdiğini göstermiştir. Ayrıca normal (hidrofilik) kanat profiline, hidrofobik ve süperhidrofobik özellik kazandırılması kanat profilinin sürüklenme katsayılarını tüm hücum açıları dikkate alındığında sırasıyla ortalama %12 ve %20 oranında düşürmüştür.
Understanding the Big Ideas Approach to the Mathematics Curriculum and Exploring its Implementation Models
Authors:   The Korea Society Of Educational Studies In Mathematics, Song Chang-geun , Lee Kyeong-Hwa
Published: February 2023

To successfully implement the Big Ideas approach in the 2022 revised mathematics curriculum, it is necessary to thoroughly understand how the above approach has been discussed in mathematics education research and to prepare the foundations for its implementation. This study analyzed the meaning of Big Ideas in mathematics education research overseas and their implementation cases; moreover, we explored the goals and content of mathematics education that can be pursued through a Big Ideas approach and investigated how the said approach can be implemented. As a result, we found that the educational objects of the Big Ideas approach in the mathematics curriculum involve cultivating mathematical competency by setting implicit knowledge of Big Ideas as the content of mathematics education. Implicit knowledge of Big ideas has the potential to enable students to gain a deeper understanding of mathematical concepts and procedures, as well as to recognize the value of mathematics.
To implement the Big Ideas approach in the mathematics curriculum, designing learning trajectories through understanding, interpretation, supplementation or substitution, as well as the creation of Big Ideas is crucial. “Topdown or bottom-up models can be considered.”
Exploring the Possibility of Process-Fortified Assessment Utilizing the ‘Navigation Bar’ and ‘Construction Protocol’ Functions of GeoGebra
Authors:   The Korea Society Of Educational Studies In Mathematics, Yang Seong Hyun
Published: February 2023

In this study, process-fortified assessment materials utilizing GeoGebra, a mathematics learning software, were developed and applied to an experimental class. Using GeoGebra’s “Navigation Bar” and “Construction Protocol” functions enabled us analyze the performance results of students’ assignments in a process-oriented manner.
Moreover, the analysis confirmed that the experimental class using the assessment materials was effective in inducing students’ confidence and interest in mathematics. Additionally, examining the students’ reviews revealed that this experimental class exerted positive effects in terms of cognitive and affective aspects, and the possibility of process-fortified assessment utilizing GeoGebra’s “Navigation Bar” and “Construction Protocol” functions was confirmed.