bluuebunny/crossref_metadata_2025 huggingface dataset:
Single System Ectopic Congenital Giant Megaureter Associated with Ipsilateral Multicystic Dysplastic Kidney
Authors: Mahalik Santosh Kumar , Tripathy Bikasha Bihary , Pati Akash Bihari , Mohanty Manoj Kumar
Published: June 2018

Congenital anomalies of the kidney and urinary tract (CAKUT) is a disease spectrum of a wide range of structural and functional anomalies. In this report, we have presented a rare case of CAKUT displaying the wide spectrum of renal and urinary tract anomalies with an unusual association like single system ectopic giant megaureter with the ipsilateral multicystic dysplastic kidney.
Photo-triggered Drug Delivery Systems for Neuron-related Applications
Authors: Li Wei , Lin Jing , Wang Tianfu , Huang Peng
Published: June 2018

The development of materials, chemistry and genetics has created a great number of systems for delivering antibiotics, neuropeptides or other drugs to neurons in neuroscience research, and has also provided important and powerful tools in neuron-related applications. Although these drug delivery systems can facilitate the advancement of neuroscience studies, they still have limited applications due to various drawbacks, such as difficulty in controlling delivery molecules or drugs to the target region, and trouble of releasing them in predictable manners. The combination of optics and drug delivery systems has great potentials to address these issues and deliver molecules or drugs to the nervous system with extraordinary spatiotemporal selectivity triggered by light. In this review, we will introduce the development of photo-triggered drug delivery systems in neuroscience research and their neuron-related applications including regulating neural activities, treating neural diseases and inducing nerve regenerations.
Liver Radioembolization: An Analysis of Parameters that Influence the Catheter-Based Particle-Delivery via CFD
Authors: Aramburu Jorge , Antón Raúl , Rivas Alejandro , Ramos Juan C. , Sangro Bruno , Bilbao José I.
Published: June 2018

Radioembolization (RE) is a valuable treatment for liver cancer. It consists of administering
radioactive microspheres by an intra-arterially placed catheter with the aim of
lodging these microspheres, which are driven by the bloodstream, in the tumoral bed. Even
though it is a safe treatment, some radiation-induced complications may arise. In trying to
detect or solve the possible incidences that cause nontarget irradiation, simulating the particle-
hemodynamics in hepatic arteries during RE by computational fluid dynamics (CFD)
tools has become a valuable approach. This paper reviews the parameters that influence the
outcome of RE and that have been studied via numerical simulations. In this numerical approach,
the outcome of RE is regarded as successful if particles reach the artery branches that
feed tumor-bearing liver segments. Up to 10 parameters have been reviewed. The variation
of each parameter actually alters the hemodynamic pattern in the vicinities of the catheter tip
and locally alters the incorporation of the particles into the bloodstream. Therefore, in general,
the local influences of these parameters should result in global differences in terms of
particle distribution in the hepatic artery branches. However, it has been observed that under
some (qualitatively described) appropriate conditions where particles align with blood
streamlines, the local influence resulting from a variation of a given parameter vanishes and
no global differences are observed. Furthermore, the increasing number of CFD studies on
RE suggests that numerical simulations have become an invaluable research tool in the study
of RE.
Phytosterols and Inflammation
Authors: Vilahur Gemma , Ben-Aicha Soumaya , Diaz-Riera Elisa , Badimon Lina , Padró Teresa
Published: June 2018

Besides the well-characterized effect of foods and supplements enriched with plant
sterols/stanols on serum LDL-C concentrations, evidence is now emerging that phytosterols
exert beneficial effects on non-lipid variables such as inflammatory and oxidative stress
markers, coagulation parameters and endothelial function. This makes sterols and stanols an
attractive alternative for dietary interventions in cardiovascular disease prevention, particularly
in populations at low or medium risk. This review aims to summarize the current knowledge
derived from experimental studies and human data on the anti-inflammatory effects of
phytosterols/stanols and their relevance in promoting atheroprotection and preventing cardiovascular
disease. The anti-inflammatory effects induced by plant sterols/stanols have been
demonstrated in in vitro studies and in experimental animal models. However, not all the
beneficial effects seen at an experimental level have translated into clinical benefit. Indeed,
clinical studies that evaluate the association between phytosterols consumption and inflammatory
variables (CRP and cytokines) are inconsistent and have not yet provided a solid answer.
Plant sterols have been proposed as useful adjuncts to statin therapy to further reduce the risk
of cardiovascular disease. However, there is limited available data and more research needs to
be done.
Microwave-Assisted Synthesis of Novel Bis-Flavone Dimers as New Anticancer Agents
Authors: McGown Andrew , Ragazzon-Smith Abby , Hadfield John A. , Potgetier Herman , Ragazzon Patricia A.
Published: June 2018

In this study, we describe a microwave-based click chemistry method used to prepare a family
of novel bis-flavone dimers. The substituted 7-hydroxy and 4’-hydroxy flavonoids were linked
through a triazole ring. The compounds were easily synthesized and purified in high yields. The bisflavonoids
were tested on different cell lines including HCT116, HepG2, MCF7 and MOLT-4. Several
analogues showed to have anticancer activity with IC50 values in the range of 20-60 μM. Flavonoids
are known for their anticancer properties and this method provides the basis for new medicinal structures.
Ultrasonic Activated, Highly Efficient and Regioselective Synthesis of a Novel Pyrrole- Linked benzo[f]chromene Scaffold in a Green Media
Authors: Tavakoli Fateme , Mamaghani Manouchehr , Sheykhan Mehdi , Mohammadipour Narjes , Rassa Mehdi
Published: June 2018

Aim and Objective: Chromene scaffold is one of the most famous oxygen heterocycles that have
widely found in plants playing pivotal roles in medicinal and synthetic chemistry. This study was undertaken
to provide a green protocol for the synthesis of novel functionalized chromen-pyrrole hybrids by a regioselective
three-component reaction via both conventional and sonochemical methods. Because of fascinating
features of these individual cores, a hybride molecular structure comprising of pyrrole and chromene moieties
could result in a novel single molecule with increased efficacy.

Materials and Methods: The synthesis of novel functionalized chromen-pyrrole hybrids was accomplished by
regioselective three-component reaction of β-naphthol, 3-(1-methyl-1H-pyrrol-2-yl)-3-oxopropanenitrile and
diverse aromatic aldehydes catalyzed by triethylamine in H2O-EtOH via both conventional and sonochemical
methods. The impact of some variants such as solvents, catalysts and temperature was also probed under both
conventional heating and sonochemical methods to accomplish the optimized reaction condition. The synthesized
products were screened for antibacterial activity against Gram positive (Ml, Bs, Sa) and Gram negative
bacteria (Ps, Ec).

Results: In initial attempt, the reaction of equimolar amounts of 2-fluorobenzaldehyde, 3-(1-methyl-1H-pyrrol-
2-yl)-3-oxopropanenitrile and β-naphthol was selected as a model reaction. The role of various solvents,
temperature and different acidic and basic catalysts on the model reaction was examined. The optimized
condition was the use of 20 mol% triethylamine in H2O-EtOH (1:1) under ultrasound irradiation at 65°C. The
scope of this reaction was screened with respect to various substituted aromatic aldehydes. Considering the results,
the electronic features of substituents affected the performance of this condensation. The reaction with
aromatic aldehydes containing electron-withdrawing groups proceeded in lower reaction time, affording the
productds in high to excellent yields while aldehydes with electron-donating groups reacted more slowly. This
three-component reaction also provided a suitable procedure for the synthesis of bis-(chromen-pyrrole) in excellent
yield. All of the synthesized products had significant antibacterial activity against the screened bacteria
(Ml, Bs, Sa, Ps, Ec).

Conclusion: A streamlined, regioselective and ecofriendly ultrasonic-promoted procedure for the synthesis of
novel substituted benzo[f]chromenes from one-pot condensation of β-naphthol, 3-(1-methyl-1H-pyrrol-2-yl)-3-
oxopropanenitrile and structurally diverse aldehydes catalyzed by triethylamine was developed. This green
protocol furnishes all the products in reduced reaction times and high yields. In addition, the synthesized novel
compounds showed narrow to wide spectral activity against the tested strains.
Evaluation of Mucosal Humoral and Cellular Immune Responses to HIV in External Secretions and Mucosal Tissues
Authors: Sabbaj Steffanie , Mestecky Jiri
Published: June 2018

The mucosal immune systems of the genital and intestinal tracts are considered as the most frequent sites of HIV-1 entry, displaying remarkable immunological differences in the systemic immune compartment which must be considered in the evaluation of humoral and cellular immune responses to HIV- 1. Marked differences in the fluids from the genital and intestinal tracts and in plasma with respect to the Ig isotypes, their levels, molecular forms and distinct effector functions must be taken into consideration in the evaluation and interpretation of humoral immune responses. Because of the low levels and highly pronounced variation in Ig content, HIV-1-specific antibody concentrations should always be related to the levels of total Ig of a given isotype. This practice will avoid inevitable differences due to the small volumes of collected fluids and sample dilution during the collection and processing of samples from external secretions. Furthermore, appropriate controls and immunochemical assays should be used to complement and confirm results generated by ELISA, which is prone to false positivity. In the evaluation of antibodymediated virus neutralization in external secretions, precautions and rigorous controls must be used to exclude the effect of innate humoral factors.

The evaluation of cell-mediated immune responses in mucosal tissues is difficult due to the low yields of cells obtained from tissue biopsies or cytobrush scrapings. Furthermore, tissue biopsies of, for example, rectal mucosa, provide information pertaining exclusively to this local site, which due to the differences in the distribution of cells of different phenotypes, does not provide generalized information to the entire intestinal tract. Importantly, studies concerning the kinetics of cellular responses are difficult to perform due to the limited availability of samples or the inability of obtaining frequently repeated tissue biopsies. For sampling the female genital tract, parallel collection of menstrual and peripheral blood yields high numbers of cells that permit their detailed phenotypic and functional analyses. In contrast to tissue biopsies, this non-traumatic collection procedure results in high cell yields and repeated monthly sampling permits extensive and parallel functional studies of kinetics and unique characteristics of HIV-1-specific cellular responses in the female genital tract and peripheral blood.
Folic Acid and Vitamin B12 Supplementation on Male Patients with Schizophrenia Predominant Negative Symptoms
Authors: Simamora Rona Hanani , Loebis Bahagia , Husada Muhammad Surya , Effendy Elmeida
Published: June 2018

Background:

Schizophrenia is a chronic mental disorder that affects approximately 1% of
the world’s population. Particularly, negative symptoms are frequently resistant and are the main contributors
to the disability on schizophrenia patients. Folic acid and vitamin B12 supplementation is the
safe and affordable approach, which can significantly improve the outcome on the patients with residual
symptoms.

Objectives:

We aimed to understand the difference of negative subscale of Positive and Negative Syndrome
Scale (PANSS) Score on patients with schizophrenia who receive risperidone with the addition
folic acid and Vitamin B12 and patients who receive only risperidone after 6 weeks.

Methods:

This study is a quasi experimental pre-test and post-test designs that are divided into two
groups, they are group receiving risperidone with the addition of folic acid and vitamin B12 and the
group receiving only risperidone. Diagnosis of schizophrenia according to the International Classification
of Diseases (ICD-10) criteria and negative symptoms assessed by using negative subscale of
PANSS Scores are observed. Statistical analysis is conducted using Statistical Package for the Social
Sciences (SPSS) software.

Results:

There was a significant difference in the mean score of negative-scale PANSS scores at the
end of week 6 between the group receiving folic acid and vitamin B12 supplementation and the group
receiving only risperidone with p = 0.002; p <0.05.

Conclusion:

Folic acid and vitamin B12 Supplementation provide benefits to patients schizophrenia.
Preparation and Characterization of Amine- and Carboxylic Acid-functionalized Superparamagnetic Iron Oxide Nanoparticles Through a One-step Facile Electrosynthesis Method
Authors: Aghazadeh Mustafa , Karimzadeh Isa , Ganjali Mohammad Reza
Published: June 2018

Background:

Surface modified magnetite nanoparticles (MNPs), can act as interesting
candidates for use in various biomedical areas. Coating MNPs with amino- or carboxylic acidfunctionalized
groups can be used as a tool for covalently binding MNPs to biomolecules for medical
uses. The conventionally used methods are also mostly multistep routes requiring purification processes.

Objective:

Herein, we developed a simple and facile approach with potentials for the large-scale
synthesis of bare and/or amine- and carboxylic acid-functionalized MNPs. The resulting product and
similarly prepared bare MNPs were studied by XRD, FT-IR, DSC-TGA, TEM, FE-SEM, DLS and
VSM analyses.

Method:

The magnetite NPs were deposited on the steel cathode by a cathodic electrochemical deposition
procedure. A galvanostatic mode was applied in the electrodeposition experiments at a dc current
density for 30 min. The purification steps were done for the prepared samples. The obtained
black powders were evaluated by characterization analyses.

Results:

The XRD peaks are well-matched with a cubic spinel structure of magnetite and confirmed
that the amino acid binding process did not result in a phase change in Fe3O4 during the electrodeposition.
The presence of amine and carboxylic functional groups on the surface of the electrosynthesized
MNPs was confirmed by FTIR. The size increases complicated the presence of the
amino acid layer on the iron oxide nanoparticles as compared with bare MNPs.

Conclusion:

We synthesized amine- and carboxylic acid-functionalized magnetite NPs through facile
novel method, and compare with the deposited bare MNPs. Our findings confirmed that the aspartic
acid and asparagine can be efficiently coated on the surface of MNPs during their CE electrodeposition.
The functionalized MNPs were found to have favorable size and proper magnetic properties
which are suitable for biomedical applications.
Obtaining Relative Permeability Curve of Carbonate Reservoir by the Weighted Method
Authors: Huang Bin , Shi Zhenzhong , Wang Ying , Fu Cheng , Cai Meng
Published: June 2018

Background:

The oil-water relative permeability curve is an important experimental data and basis for oilfield development scheme and dynamic prediction. The characteristics of oil and water relative permeability curves in different reservoirs are otherness.

Objective:

In order to enable various effects to be reflected in the standardized relative permeability curve, the standardized relative permeability curve can reflect the characteristics of each core.

Method:

The core is taken from core wells in a similar flow unit. The oil-water relative permeability curves are measured by indoor physical simulation experiments. The oil-water relative permeability curves of representativeness and conforming to hydrodynamic characteristics are screened. Because the porosity and permeability of different cores have different effects on the relative permeability curve, the weight of the porosity and permeability of each core is added to the standard relative permeability curve in the process of solving standardized relative permeability curve.

Results:

A new method that the weight method to be used to solve the problem of the standardized relative permeability curve is obtained. The comparison of the new method and the average method shows that both of them are highly consistent.

Conclusion:

The patent on the solution of the relative permeability curve is improved. Considered the effect of different cores of porosity and permeability on the relative permeability curve. Calculated the weight of the porosity and permeability of different cores. The representative normalized relative permeability curve is obtained by using the weight method.
Phytochemical Profiles, Antioxidant and Antibacterial Activities of 11 Phellinus Mushrooms Collected in Thailand
Authors: Sunthudlakhar Punjaporn , Sithisarn Pongtip , Wannissorn Bhusita , Jarikasem Siripen , Rojsanga Piyanuch
Published: June 2018

Background:

Phellinus mushrooms are locally available in Thailand. They have been traditionally used for medicinal purposes including tonics, for cancer treatment and for immune system stimulation.  Objective: To evaluate the in vitro antioxidant, antibacterial activities and the phytochemical information of the extracts from 11 selected Phellinus mushrooms collected in Thailand.

Methods:

Eleven Phellinus mushrooms were collected from the Northeastern part of Thailand. Their ethanol and water extracts were tested for in vitro antioxidant activities using a DPPH scavenging assay, FRAP assay and TBARS method while the antibacterial effects were determined by agar disk diffusion and broth microdilution methods. The phytochemical profiles of the Phellinus mushroom extracts were evaluated using TLC and HPLC techniques. The total phenolic and total flavonoid contents of the extracts were evaluated by Folin-Ciocalteu and aluminium chloride methods, respectively. While total carbohydrate and total triterpene contents were evaluated by phenolsulfuric acid and vanillin perchloric acid methods, respectively.

Results:

Most ethanol extracts from Phellinus mushrooms exhibited moderate antioxidant effects especially extracts from P. everhartii, P. hippophaëicola and P. pini var. microporus while P. igniarius var. cinereus ethanol extract exhibited inhibitory effects to Helicobacter pylori both normal and resistant strains, this extract also showed the strongest inhibitory effect against Staphylococcus aureus. Most Phellinus mushroom extracts exhibited similar TLC and HPLC fingerprints with the chromatographic bands corresponding to phenolics, flavonoids and terpenoids. Protocatechuic acid was identified in most Phellinus mushroom extracts.

Conclusion:

Phellinus mushrooms especially, P. everhartii could be developed as sources of antioxidants while P. igniarius var. cinereus indicated the potential to inhibit H. pylori. Protocatechuic acid could be used as a marker for quality control of Phellinus mushroom raw materials and extracts.
Isolation of Natural Compounds from Syzygium densiflorum Fruits and Exploring its Chemical Property, Therapeutic Role in Diabetic Management
Authors: Gopinath Krishnasamy , Subbiah Nagarajan , Karthikeyan Muthusamy
Published: June 2018

Background:

Syzygium densiflorum Wall. ex Wight & Arn (Myrtaceae) has been traditionally
used by the local tribes of the Nilgiris, Tamil Nadu, India, for the treatment of diabetes.

Objective:

This study aimed to isolate the major phytoconstituents from the S. densiflorum fruits and
to perform computational studies for chemical reactivity and biological activity of the isolated compound.

Materials and Methods:

Two different compounds were isolated from ethanolic extract of S.
densiflorum fruits and purified using HPLC. The structures of the compounds were elucidated on the
basis of their 1H NMR, 13C NMR, 1H-1H COSY, HMBC, HRESIMS, and FT-IR data. Further, the
chemical reactivity of the compounds was analyzed by density functional theory calculations and its
therapeutic role in diabetic management was examined by comparing the structure of isolated compounds
with previously reported bioactive compounds.

Results:

Of the two compounds ((6,6 & 1-kestopentaose (1) and 6-(hydroxymethyl)-3-[3,4,5- trihydroxy-
6-[(3,4,5-trihydroxyoxan-2-yl)oxymethyl]oxan-2-yl]oxyoxane-2,4,5-triol)(2)). β-glucosidase,
β-galactosidase, α-glucosidase and β-amylase inhibition activity of the compounds were predicted by
structure activity relationship.

Conclusion:

Structure-activity relationship analysis was performed to predict the therapeutic role of
isolated compounds. These computational studies may be performed to minimize the efforts to determine
the therapeutic role of natural compounds.
Science and Technological Understanding of Nano-ionic Resistive Memories (RRAM)
Authors: Dash C.S. , Prabaharan S.R.S.
Published: June 2018

Ion transport in the solid state has been regarded as imperative with regards to high energy density electrochemical storage devices (for instance, batteries) for efficient electric mobility. Of late, there is another niche application involving ion transport in solid state which manifested itself as nonvolatile memory namely memristor. Such memories are classified under the emerging category of novel solid state Resistive Random Access Memories (RRAM). In 2008, HP labs unveiled the first practical memristor device employing TiO2 and non-stoichiometric titania as bilayer stack structure and on both sides of two titania layers platinum (pt) are used as blocking electrode for ions. It is understood that switching fundamentals are correlated to the filamentary conduction in metal oxide memristors owing to the formation and rupture of the filament-like nano-dendrites, one of the key mechanisms widely accepted in the arena of memristor analysis. This paper critically reviews the fundamental materials being employed in novel memristor memories. It is believed that solid electrolytes (fast ion conductors) are the fundamental building blocks of these memories. We have chosen a few archetypes, solid electrolytes are considered and their impact on the state-of-art research in this domain is discussed in detail. An indepth analysis of the fundamentals of resistive switching mechanism involved in various classes of memristive devices viz., Electrochemical Metallization Memories (ECM) and Valence Change Memories (VCM) is elucidated. A few important applications of memristors such as neuristor and artificial synapse in neuromorphic computing are reviewed as well.
In-Vitro and In-Silico Characterization of Xylose Reductase from Emericella nidulans
Authors: Ahuja Vishal , Sharma Aashima , Rathour Ranju Kumari , Sharma Vaishali , Rana Nidhi , Bhatt Arvind Kumar
Published: June 2018

Background:

Lignocellulosic residues generated by various anthropogenic
activities can be a potential raw material for many commercial products such as biofuels,
organic acids and nutraceuticals including xylitol. Xylitol is a low-calorie nutritive sweetener
for diabetic patients. Microbial production of xylitol can be helpful in overcoming the
drawbacks of traditional chemical production process and lowring cost of production.

Objective:

Designing efficient production process needs the characterization of required
enzyme/s. Hence current work was focused on in-vitro and in-silico characterization of
xylose reductase from Emericella nidulans.

Methods:

Xylose reductase from one of the hyper-producer isolates, Emericella nidulans
Xlt-11 was used for in-vitro characterization. For in-silico characterization, XR sequence
(Accession No: Q5BGA7) was used.

Results:

Xylose reductase from various microorganisms has been studied but the quest for
better enzymes, their stability at higher temperature and pH still continues. Xylose reductase
from Emericella nidulans Xlt-11 was found NADH dependent and utilizes xylose as its sole
substrate for xylitol production. In comparison to whole cells, enzyme exhibited higher
enzyme activity at lower cofactor concentration and could tolerate higher substrate
concentration. Thermal deactivation profile showed that whole cell catalysts were more
stable than enzyme at higher temperature. In-silico analysis of XR sequence from Emericella
nidulans (Accession No: Q5BGA7) suggested that the structure was dominated by random
coiling. Enzyme sequences have conserved active site with net negative charge and PI value
in acidic pH range.

Conclusion:

Current investigation supported the enzyme’s specific application i.e.
bioconversion of xylose to xylitol due to its higher selectivity. In-silico analysis may provide
significant structural and physiological information for modifications and improved stability.
The virtual cognitive health (VC Health) study: design, recruitment, and baseline characteristics of a fully remote single-arm pre-post study to prevent or delay cognitive impairment in older adults (Preprint)
Authors: Bott Nick , Kumar Shefali , Krebs Caitlyn , Glenn Jordan M , Madero Erica N , Juusola Jessie
Published: June 2018

BACKGROUND

A growing body of evidence supports the use of lifestyle interventions for preventing or delaying the onset of Alzheimer’s disease (AD) and other forms of dementia in at-risk individuals. The development of virtually delivered programs would increase the scalability and reach of these interventions, but requires validation to ensure similar efficacy to brick and mortar options.

OBJECTIVE

The aims of this study are to describe the study design, recruitment process, and baseline participant characteristics of the sample in the virtual cognitive health (VC Health) study. Future analyses will assess the impact of the remotely delivered lifestyle intervention on (1) cognitive function, (2) depression and anxiety, and (3) various lifestyle behaviors, including diet, exercise, and sleep in a cohort of older adults with subjective memory decline. Additional analyses will explore feasibility outcomes, as well as the participants’ engagement patterns with the program.

METHODS

Older adults (age 60-75) with subjective memory decline as measured by the Subjective Cognitive Decline (SCD-9) questionnaire, and who reported feeling worried about their memory decline, were eligible to participate in this single-arm pre-post study. All participants enrolled in the year-long virtual intervention, which consists of health coach-guided lifestyle change for improving diet, exercise, sleep, stress, and cognition. All components of this study were conducted virtually, including the collection of data and the administration of the intervention. Participants were assessed at baseline, 12 weeks, 24 weeks, and 52 weeks with online surveys and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) test. Intention-to-treat analysis will be conducted on all outcomes.

RESULTS

A total of 85 participants enrolled in the intervention and 82 are included in the study sample (3 participants withdrew). The study cohort is 74% female, 88% Caucasian, 78% overweight or obese, and 67% have at least a college degree. The average baseline RBANS score was 95.9±11.1, which is within age-adjusted norms. The average SCD-9 score was 6.0±2.0, indicating minor subjective cognitive impairment at the beginning of the study. Average baseline Generalized Anxiety Disorder (GAD-7) scores were 6.2±4.5 and Patient Health Questionnaire (PHQ-9) scores were 8.5±4.9, indicating mild levels of anxiety and depression at baseline.

CONCLUSIONS

Virtually delivered lifestyle interventions may represent a scalable solution for the prevention or delay of AD. The results of this study will provide the first evidence for the efficacy of a fully remote intervention and lay the groundwork for future investigations.

CLINICALTRIAL

NCT02969460
Formação dos professores para o uso das tecnologias da informação e comunicação
Authors: VERGNA MÁRCIA , SILVA ANTÔNIO
Published: June 2018

RESUMO Este artigo investiga a formação inicial e continuada dos professores para o uso das tecnologias da informação e continuação na prática pedagógica. Para tal fim, realizou-se pesquisa de campo, utilizando o questionário como instrumento de coleta de dados. O público alvo foram os professores de Língua Portuguesa que trabalham no ensino médio das escolas estaduais de Linhares – ES. Essa pesquisa é descritiva, de abordagem qualitativa. Os dados indicam que a maioria dos professores não teve em sua formação inicial preparação para utilizar essas tecnologias como recurso pedagógico. Quanto à formação continuada, a maioria afirmou já ter realizado capacitação, sendo essa formação ofertada pelo poder público. Espera-se que essa pesquisa possa subsidiar ações que visem ao melhor aproveitamento desses recursos no espaço escolar. Palavras-chave: Língua portuguesa; Tecnologias da informação e comunicação; Prática pedagógica.   Abstract: This following paper investigates the initial and continuous training of teachers for the use of information technologies and continuation in pedagogical practice. A field research was performed by using a questionnaire as a data collection instrument. The target audience was the Portuguese language teachers who work in state high schools of Linhares – ES, Brazil. This research has used a descriptive, qualitative approach. The data indicate that most of the teachers surveyed did not have in their initial training a formal preparation to use such technology as a pedagogical resource. As for ongoing training, most of them said that they had already completed training, which was offered by the public authorities. It is hoped that this research can reinforce actions that aim the best use of these resources in schools.   Keywords: Portuguese language; Communication and information technologies; Education pratice. RESUMEN Este artículo investiga la formación inicial y continuada de los profesores para el uso de las tecnologías de la información y continuación en la práctica pedagógica. A tal fin, se realizó una investigación de campo, utilizando el cuestionario como instrumento de recolección de datos. El público objetivo fueron los maestros de habla portuguesa que trabajan en la educación secundaria en los colegios de Linhares - ES. Esta investigación es descriptiva, de enfoque cualitativo. Los datos indican que la mayoría de los profesores no tuvieron en su formación inicial preparación para utilizar esas tecnologías como recurso pedagógico. En cuanto a la formación continuada, la mayoría afirmó ya haber realizado capacitación, siendo esa formación ofrecida por el poder público. Se espera que esta investigación pueda subsidiar acciones que apunte al mejor aprovechamiento de esos recursos en el espacio escolar. Palabras clave: Portugués; Tecnologías de la información y comunicación; Pratica pedagógica.DOI: http://dx.doi.org/10.22169/revint.v13i28.1291
Tecnologia na educação superior: estratégias pedagógicas bem sucedidas para estudantes surdos
Authors: Varela Aline Martins , Rausch Rita Rausch
Published: June 2018

RESUMO Esta pesquisa teve por objetivo analisar as principais práticas pedagógicas bem-sucedidas na Educação Superior na compreensão de estudantes surdos. Trata-se de uma pesquisa qualitativa em que os dados foram coletados por meio de entrevista semiestruturada em libras com 10 acadêmicos surdos de diferentes cursos de graduação de uma Instituição de Educação Superior de Blumenau – SC. Os dados foram analisados a partir da técnica de Análise de Conteúdo e os resultados indicaram que uma das principais estratégias pedagógicas bem sucedidas na compreensão dos estudantes surdos é o uso das tecnologias da informação e comunicação nos processos de ensinar e aprender. Os participantes destacaram que as tecnologias facilitam a aprendizagem de estudantes surdos, permitindo que façam relações entre conhecimentos concretos e abstratos, e contribuindo com o processo de inclusão.   Palavras-chave: Tecnologias da Informação e Comunicação; Educação Superior; Surdez.   ABSTRACT The following study aimed to analyze the main successful pedagogical practices in Higher Education when it comes to deaf students. It is a qualitative research in which the data were collected through a semi-structured interview in Libras (Brazilian Sign Language) along with 10 deaf students from different undergraduate courses of a higher education institution of Blumenau – SC, Brazil. The data were analyzed using the Content Analysis technique and the results indicated that one of the main successful pedagogical strategy regarding deaf students is the use of information and communication technologies in the processes of teaching and learning. Participants emphasized that technologies facilitate deaf students learning, allowing them to connect concrete and abstract knowledge, which contributes to the inclusion process.   Keywords: Information and Communication Technologies; College Education; Deafness.   RESUMEN Esta investigación tuvo por objetivo analizar las principales prácticas pedagógicas exitosas en la Educación Superior en la comprensión de estudiantes sordos. Se trata de una investigación cualitativa en la que los datos fueron recogidos por medio de una entrevista semiestructurada en libras con 10 académicos sordos de diferentes cursos de graduación de una Institución de Educación Superior de Blumenau - SC. Los datos fueron analizados a partir de la técnica de Análisis de Contenido y los resultados indicaron que una de las principales estrategias pedagógicas exitosas en la comprensión de los estudiantes sordos es el uso de las tecnologías de la información y comunicación en los procesos de enseñanza y aprendizaje. Los participantes destacaron que las tecnologías facilitan el aprendizaje de estudiantes sordos, permitiendo que hagan relaciones entre conocimientos concretos y abstractos, y contribuyendo con el proceso de inclusión. Palabras clave: Tecnologías de la Información y Comunicación; Educación Superior; Sordera. DOI: http://dx.doi.org/10.22169/revint.v13i28.1295
Social Housing Competencies: Expertise for a New Era
Authors: Coombs Michelle , Coplan Isaac
Published: June 2018

This article outlines organizational-level competencies within the changing social housing context in Ontario. The changing context is occurring at the same time as key board members and staff are retiring. This prompts the question of how the sector can ensure excellent housing for low- and middle-income tenants into the future, while keeping in mind its social justice origins. Social constructionist, adult education, and critical theoretical traditions guided the research questions and methodology of this study, resulting in a working definition of organizational competencies. Organizational competencies have been identified through a sequential mixed methods approach. Four key competency clusters have been identified: capital asset, sectoral operational, people-oriented, and strategic. These clusters and the competencies they contain provide a model to assist organizations in meeting their social justice and business goals into the future.RÉSUMÉCet article décrit les compétences organisationnelles requises dans le domaine du logement social en Ontario dans un contexte changeant. Ce contexte change en même temps que des membres clés de conseils d’administration et des employés clés sont en train de prendre leur retraite. Ces circonstances font réfléchir sur comment le secteur pourra continuer à fournir des logements désirables aux locataires à faible ou moyen revenu tout en respectant les principes de justice sociale. Pour cette étude, les traditions de construction sociale, d’éducation pour adultes et de théorie critique ont guidé la formulation de questions de recherche et la méthodologie, avec comme résultat une définition pratique de ce que sont les compétences organisationnelles. Ces dernières ont été identifiées au moyen d’une recherche par méthodes mixtes séquentielles. Quatre regroupements de compétences clés ont été cernés : actif immobilisé, opération par secteurs, service au public, et stratégie. Ces regroupements et les compétences qu’ils privilégient peuvent servir de modèles pour aider les organisations à rencontrer leurs futurs objectifs en justice sociale et en affaires.
A FUNDADA SUSPEITA E A ABORDAGEM POLICIAL MILITAR
Authors: Da cruz Marcio Antonio , Pylro Simone Chabudee
Published: June 2018

Este trabalho buscou apresentar uma análise sobre os elementos concretos e sensíveis que levam policiais militares a desconfiarem de um cidadão e abordá-lo, baseado na fundada suspeita. O Objetivo foi discutir os principais elementos que justificam, na concepção do policial militar do município de Vila Velha, uma construção da fundada suspeita que culmine na abordagem policial, à luz da legislação vigente. O conflito encontra-se no conceito de fundada suspeita que não foi definido por lei nem tampouco pelos doutrinadores, conceito que permite a ação do Estado através do poder de polícia. A metodologia adotada envolveu a pesquisa de campo, cujo instrumento para coleta de dados foi a entrevista em profundidade junto à policiais militares que trabalham na área do 4º Batalhão de Polícia Militar lotados na 1ª Companhia localizada no Parque da Prainha (centro), e lotados na 4ª Companhia localizada no Residencial Jabaeté (periferia), que atuam no policiamento ostensivo. A análise dos dados obtidos proporcionou verificar que para os policiais entrevistados a construção da fundada suspeita se dá principalmente através do comportamento suspeito, do lugar suspeito relacionados ao horário, principalmente na busca por drogas e armas.
A ORDEM É MATAR: Uma análise da produção da sociabilidade violenta na favela.
Authors: Fernandes Ionara Dos Santos
Published: June 2018

Este trabalho tem por objetivo refletir sobre a produção de assassinatos em favelas do Rio de Janeiro cometidos por policiais e traficantes, a partir de uma leitura de crianças e adolescentes pobres e moradoras desses espaços. A análise se associa ao contexto de reedição do suplício de Foucault (2014), no sentido de fazer relações com os corpos estirados nestes locais e sua ostentação num contexto que evidenciar o poder de gestão com base na prerrogativa de soberania dos grupos de controle armado nos territórios favelados.
A Central Disque-Denúncia e sua relação com as Polícias (ou os policiais) cariocas
Authors: Patricio Luciane
Published: June 2018

O presente artigo busca recuperar parte das discussões feitas no trabalho “Disque-Denúncia: a arma do cidadão”- Um estudo sobre os processos de construção da verdade a partir das experiências da Central Disque-Denúncia do Rio de Janeiro, dissertação de mestrado defendida em 2006 pelo Programa de Pós-Graduação em Antropologia (PPGA) da Universidade Federal Fluminense. Passados 11 anos da publicação original (e 22 anos da criação da Central), o Disque-Denúncia segue em funcionamento. Para os objetivos propostos no presente artigo busca-se compreender como se dá a relação entre a Central Disque-Denúncia e as Polícias do Rio de Janeiro. Sendo a informação anônima recebida pela Central uma “ferramenta-meio”, ou seja, um dado que demanda ser confirmado, investigado, conferido e/ou rejeitado, o funcionamento da Central depende de forma indispensável dos órgãos encarregados de checar as informações recebidas e, sobretudo da relação (mais ou menos institucionalizada, mais ou menos pessoalizada) estabelecida entre os profissionais do Disque-Denúncia e órgãos policiais que fazem uso dessa fonte de dados.
NOVAS TECNOLOGIAS PARA PRÁTICAS ANTIGAS NA ADMINISTRAÇÃO DE JUSTIÇA: DOIS TRABALHOS DE CAMPO NO SISTEMA JUDICIAL BRASILEIRO
Authors: Epifani Filho Marco Aurélio Alves , Sanandres Luiza Barçante
Published: June 2018

O objetivo deste artigo é analisar o impacto da utilização de novas tecnologias no sistema de justiça brasileiro, através da comparação entre duas pesquisas de campo, uma realizada na Justiça do Trabalho e a outra no Ministério Público. Assim, procura-se compreender como os atores do campo adaptam as suas atividades e propósitos institucionais, alterando os programas e orientações estruturais impostas pelos sistemas digitais. Como conclusão, a sugestão de que as reformas tecnológicas não providenciam mudanças gerais no nível da burocracia, mas explicitam políticas particularizadas em diferentes contextos institucionais.
SOLUÇÃO CONSENSUAL DE CONFLITOS NO CÓDIGO DE PROCESSO CIVIL BRASILEIRO: ENTRE AS ESPERANÇAS DO LEGISLADOR E AS POSSIBILIDADES DA EMPIRIA
Authors: Leal Filpo Klever Paulo , Lupetti Baptista Bárbara Gomes
Published: June 2018

Pretende-se refletir sobre a forma como vêm sendo implementadas as audiências de conciliação e de mediação, introduzidas no Código de Processo Civil Brasileiro. Embora a lei enfatize a importância desses institutos, atores do processo vêm oferecendo importantes resistências à sua utilização. O paper contém análise de dados coletados em pesquisa exploratória, buscando compreender os motivos de tal resistência. Busca-se compreender distintas perspectivas que se situam entre as esperanças do legislador e os limites e possibilidades impostas pela empiria à chamada "cultura do consenso". A pesquisa privilegia a observação cotidiana de audiências associada a entrevistas com operadores do direito realizadas no Tribunal de Justiça do Rio de Janeiro, entre 2016 e 2017.
Desigualdade de Renda Salarial no Brasil no período 2001 a 2012
Authors: Araujo Jair Andrade , Vasconcelos Joyciane Coelho
Published: June 2018

A alta concentração de renda é um dos principais problemas enfrentados pelo Brasil. Nesse contexto, a importância desse tema se justifica tanto por questões de equidade social quanto pelos efeitos potenciais que a distribuição da renda tem sobre o crescimento econômico, pobreza, bem-estar. Nesse sentido, este trabalho busca um melhor entendimento da conexão existente entre educação, mercado de trabalho e desigualdade de renda, tendo como base os microdados da PNADs para os anos 2001, 2006 e 2012. Aplicando uma metodologia de decomposição proposto por Fields (2002) foi possível identificar os fatores que causaram a redução na desigualdade de salários no Brasil com base nas suas principais fontes de produção e reprodução: imperfeições de mercado e heterogeneidade dos trabalhadores. Verificou-se que houve discriminação de cor e sexo, logo os homens são melhores remunerados que a mulheres, no entanto essa discriminação vem se reduzindo no período analisado. A decomposição mostra que a variável educação continua sendo o mais importante determinante da desigualdade de renda salarial. Logo, modificações nos níveis educacionais da população brasileiras, possuem uma importância considerável na desigualdade de renda destas, o que deve ser considerado como um fator relevante na consecução de políticas públicas.
Estudo das Empresas não-Financeiras no Setor Real: Uma Análise do Maximizing Shareholder Value no Brasil
Authors: Attílio Luccas Assis
Published: June 2018

Com uma amostra de cem empresas não-financeiras de capital aberto que atuam no território brasileiro, esse artigo analisa o comportamento dessas instituições no setor real da economia entre os anos de 1997 a 2013. O objetivo é investigar se a estratégia de maximizing shareholder value esteve presente na gestão dessas instituições. Os resultados sugerem que a maximização do valor do acionista não faz parte da conduta dessas empresas, pelo contrário, os dados apontam que essas corporações têm auxiliado no desempenho macroeconômico do Brasil, por meio do aumento da produção e dos investimentos produtivos.
Desenvolvimento socioeconômico brasileiro entre 1990 e 2012: considerações sobre a informalidade do trabalho à luz da teoria do duplo movimento de Polanyi
Authors: Vargas Juliano
Published: June 2018

Esse estudo examina os nexos de convergência entre o desenvolvimento socioeconômico e a evolução da informalidade no mercado nacional de trabalho no interregno 1990-2012, à luz da teoria do duplo movimento de Polanyi. Duas fases são fundamentais para a discussão pretendida: a) fim do século XX, em que o Brasil passou por reformas que resultaram no aumento da informalidade no mercado de trabalho; b) início do século XXI, com renovada participação política do Estado e da sociedade civil, que gerou diminuição moderada do trabalho informal. A concepção polanyiana de duplo movimento mostra-se como instrumento útil para a compreensão primeiro da “grande transformação” e na sequência também para o entendimento do “contramovimento” (parcial), ambos verificados no país após 1990. Conclui-se que o caminho para mitigar a historicamente alta informalidade no Brasil perpassa pelo desincrustamento desse hábito enraizado da sociedade em geral.
EDITORIAL: NOVOS RUMOS PARA A TRABALHONECESSÁRIO
Authors: Tiriba Lia , Rodrigues Maria Cristina Paulo , Antunes José Luiz Cordeiro
Published: June 2018

Poderíamos iniciar este Editorial destacando o quanto nos sentimos desafiados e felizes em assumir a editoria daTrabalhoNecessário – revista criada em 2003 e que contou com o árduo trabalho dos editores e editoras que nos antecederam: José Rodrigues, Ronaldo Rosas, Francisco José da Silveira Lobo Neto, Luciana Requião, Maria Inês Bonfim e, desde 2013, Sonia Rummert e Jaqueline Ventura – e que tanto se empenharam para conquistar o reconhecimento acadêmico da TN.
CONCEPÇÕES DE HOMEM, SOCIEDADE E MUNDO DO TRABALHO EM PROJETOS DE FORMAÇÃO DE CURSOS DA ÁREA DA SAÚDE
Authors: Sthal Hellen Cristina , Almeida Leal Cátia Regina Assis
Published: June 2018

A reorientação da formação profissional em saúde no Brasil tem ganhado espaço crescente no debate científico. Buscou-se contribuir com esse debate investigando as concepções de homem e de sociedade que embasam os projetos de formação dos cursos de graduação da área da saúde da UFG - Regional Jataí, e a abordagem sobre o mundo do trabalho presente nesses projetos. Os dados, analisados, à luz do materialismo histórico-dialético, revelam concepções acríticas e individualistas de homem e de mundo/sociedade; e uma proposta de formação voltada, em grande parte, ao mercado de trabalho.
A PRÁXIS POLÍTICA COMO ATIVIDADE FORMATIVA DOS TRABALHADORES DA PESCA DA COLÔNIA Z-16 DE CAMETÁ-PA
Authors: Martins Egídio , Silva Valdiléia Carvalho
Published: June 2018

O presente artigo é parte de resultado de pesquisa do doutorado da linha Políticas Públicas Educacionais do Programa de Pós-Graduação em Educação do Instituto de Ciências da Educação da Universidade Federal do Pará. Pautou-se no materialismo histórico dialético, tendo uma abordagem qualitativa, com ênfase no estudo de caso. Coletaram-se os dados através da entrevista semiestruturada e análise documental. O tratamento dos dados seguiu as orientações da análise de conteúdo. A práxis política dos pescadores da Z-16 é construída a partir da organização socioeconômico, político e formativo ao longo do processo histórico, materializada no cotidiano das relações interna e externa da entidade. São ações que possibilitam os pescadores garantirem suas subsistências, ao mesmo tempo em que se contrapõem a lógica da classe dominante.
INTENSIFICAÇÃO E PRECARIZAÇÃO SOCIAL DO TRABALHO DE PROFESSORES DE ESCOLA PÚBLICA: UM ESTUDO EXPLORATÓRIO NA REGIÃO DA BAIXADA FLUMINENSE (RJ)
Authors: Morais Luiz Armando , Souza Katia Reis , Santos Gideon Borges
Published: June 2018

O estudo teve como objetivo principal investigar as relações entre o trabalho e a saúde de professores do ensino fundamental em escola pública. A metodologia adotada foi de caráter qualitativo e exploratório. Foram realizadas entrevistas semiestruturadas individuais com cinco professores. Quanto à interpretação dos materiais, utilizou-se a análise de conteúdo, mais especificamente a técnica de análise temática. No que tange aos resultados, confirmou-se a ideia segundo a qual a intensificação e a precarização social das condições do trabalho docente, em escolas públicas, passa por um processo de aprofundamento, o que gera efeitos na saúde dos professores.