bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of a Support System for Physicians and Patients during Rehabilitation
Authors: Barrera-Leon Luisa , Canonico Massimo , Desimoni Francesco , de Sire Alessandro , Invernizzi Marco , Lippi Lorenzo
Published: September 2024

Musculoskeletal disorders are common among older adults, affecting mobility and quality of life. Effective rehabilitation is essential, but the implementation of programs faces challenges. Traditional methods often necessitate in-person assessments, which can be difficult for older adults with mobility limitations. Telerehabilitation offers a solution, bringing therapy closer to patients. However, the accurate remote monitoring of health and performance remains a challenge. This study addresses this gap by developing and validating the System for Tracking and Evaluating Performance (STEP). STEP is a hardware-software system that automates physical performance tests, eliminating the need for constant expert supervision. The system focuses on three standard tests: the Six-Minute Walking Test (6MWT), the Ten-Meter Walking Test (10MWT), and the 30-s Sit-to-Stand Test (30STS). Validation compared results from the STEP app with in-person assessments by physicians for patients undergoing rehabilitation after knee or hip arthroplasty. The study found strong positive correlations between the app’s results and the physicians’ assessments for all tests. These findings demonstrate the STEP system’s potential as a reliable tool for remote physical performance assessment. Further research is needed to explore its integration into clinical practice and cost-effectiveness in reducing the need for operator assistance in monitoring patients with physical limitations.
Hepatocellular Carcinoma (HCC) Metastasis to the Diaphragm Muscle: A Systematic Review and Meta-Analysis of Case Reports
Authors: Kocjan Janusz , Rydel Mateusz , Adamek Mariusz
Published: September 2024

The purpose of this study was to conduct a systematic review and meta-analysis of case reports presenting HCC spread to the diaphragm muscle and to determine possible risk factors for this condition. An extensive literature search was performed using the following electronic databases: MEDLINE, CINAHL, ScienceDirect, Google Scholar, and DOAJ. A total of 18 articles describing 27 hepatocellular carcinoma patients were included in this review. The presence of HCC cells in the superior liver segment is strongly associated with metastases to the diaphragm. Among the two types of diaphragm involvement by HCC cells, diaphragm infiltration occurs much more frequently than diaphragm adhesion. However, an HCC nodule in the 8th liver segment and a higher number of liver segments involved by HCC cells predispose patients to diaphragm adhesion. Hepatitis B is a risk factor for diaphragm metastases in recurrent HCC. The tumor diameter is not associated with HCC spread to the diaphragm muscle. We did not find specific symptoms reported by patients that could indicate HCC metastasis to the diaphragm muscle. The presence of hepatitis B and the localization of HCC cells in superior liver segments, especially in the 8th liver segment, should be take into consideration in the diagnostic process.
Effect of Centrality on Physical Activity in Late Childhood: A 1-Year Prospective Cohort Study
Authors: Tamura Kazuya , Saito Takashi , Ueda Yuya , Goto Ryo , Yamada Naoki , Akisue Toshihiro , Ono Rei
Published: September 2024

Background/Objectives: Engaging in physical activity (PA) is crucial for children’s physical and mental health, with PA in childhood influencing lifelong activity levels. However, PA during childhood tends to decrease with age. Childhood friendship networks influence various health behaviors, including physical activity. Centralities are objective measures of an individual’s position and role in friendship networks. The relationship between centrality and PA is inconsistent. This study aimed to determine how centrality affects changes in PA in late childhood longitudinally and to investigate the distribution of centrality in the network. Methods: This prospective cohort study recruited fourth- and fifth-grade children (9–11 years old). A total of 143 children participated. We calculated three centralities—in-degree, closeness, and betweenness—based on social network analysis (SNA). PA was assessed using the physical activity questionnaire for older children (PAQ-C). To explore the relationship between centralities and the percentage change in PA, a multivariate logistic regression analysis was performed. Results: Children with higher closeness had a significantly higher rate of decrease in PA after adjusting for confounding factors. There was no significant association between betweenness and percentage change in PA (p = 0.66) or in-degree and percentage change in PA (p = 0.21). Conclusions: This study highlights the importance of considering social network dynamics in PA interventions, particularly for children with high social closeness. Future research should incorporate objective PA measures and explore broader social networks to enhance intervention strategies, especially for Generation Z and Alpha, who experience unique opportunities and motivations for PA due to pervasive digital environments.
Analysis of the Long Non-Coding and Messenger RNA Expression Profiles in the Skin Tissue of Super Merino and Small-Tailed Han Sheep
Authors: Fu Jiaqi , Zhang Xinyu , Wang Dan , Liu Wenqing , Zhang Caihong , Wang Wei , Fan Wei , Zhang Lichun , Sun Fuliang
Published: September 2024

Wool quality and yield are two important economic livestock traits. However, there are relatively few molecular studies on lncRNA for improving sheep wool, so these require further exploration. In this study, we examined skin tissue from the upper scapula of Super Merino (SM) and Small-Tailed Han (STH) sheep during the growing period. The apparent difference was verified via histological examination. High-throughput RNA sequencing identified differentially expressed (DE) long non-coding (lncRNAs) and messenger RNAs (mRNAs). The target gene of DE lncRNA and DE genes were enrichment analyzed using Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG). A Reverse Transcription quantitative Polymerase Chain Reaction (RT-qPCR) was used to verify randomly selected DE lncRNAs and mRNAs. Finally, the DE, RAC2, WNT11, and FZD2 genes, which were enriched in the Wnt signaling pathway, were detected via immunohistochemistry. The results showed that a total of 20,888 lncRNAs and 31,579 mRNAs were identified in the skin tissues of the two sheep species. Among these, 56 lncRNAs and 616 mRNAs were differentially expressed. Through qRT-PCR, the trends in the randomly selected DE genes’ expression were confirmed to be aligned with the RNA-seq results. GO and KEGG enrichment analysis showed that DE lncRNA target genes were enriched in GO terms as represented by epidermal and skin development and keratin filature and in KEGG terms as represented by PI3K-Akt, Ras, MAPK, and Wnt signaling pathways, which were related to hair follicle growth and development. Finally, immunohistochemistry staining results indicated that RAC2, WNT11, and FZD2 were expressed in dermal papilla (DP). The lncRNAs MSTRG.9225.1 and MSTRG.98769.1 may indirectly participate in the regulation of hair follicle growth, development, and fiber traits by regulating their respective target genes, LOC114113396(KRTAP15-1), FGF1, and IGF1. In addition, MSTRG.84658.1 may regulate the Wnt signaling pathway involved in the development of sheep hair follicles by targeting RAC2. This study provides a theoretical reference for improving sheep breeding in the future and lays a foundation for further research on the effects of MSTRG.84658.1 and the target gene RAC2 on dermal papilla cells (DPC).
The Mediterranean Diet in the Era of Climate Change: A Reference Diet for Human and Planetary Health
Authors: Koliaki Chrysi C. , Katsilambros Nicholas L. , Dimosthenopoulos Charilaos
Published: September 2024

Nowadays, climate change constitutes an enormous global threat for human health and environmental sustainability. The expanding world population and the increased global need for food production have an important negative impact upon the environment. Diet can link human health with environmental sustainability. Food production systems are closely related to anthropogenic greenhouse gas emissions and the aggravation of climate change, and current Western-type, animal-based dietary patterns may lead to adverse environmental footprints. In this present narrative review, we address the interconnection of the Mediterranean diet (MD) with climate change and sustainability. The MD is a highly recommended dietary intervention for the prevention and management of various endocrine and cardiometabolic diseases. Beyond its evidence-based, health-promoting effects, it also has a beneficial environmental impact, reducing greenhouse gas emissions and enhancing biodiversity, food security, and sustainability. Based on the evidence reviewed herein, the MD should be incorporated within the framework of a “One Health” model, which involves the improvement not only of human health but also of planetary health and food system sustainability. Our review aims to provide a stimulus for health professionals to strongly recommend the implementation of the MD under the current pressure of climate change, despite all barriers, targeting both human health preservation and planetary well-being.
Magnetron Sputtering as a Solvent-Free Method for Fabrication of Nanoporous ZnO Thin Films for Highly Efficient Photocatalytic Organic Pollution Degradation
Authors: Ćwik Kamila , Zawadzki Jakub , Zybała Rafał , Ożga Monika , Witkowski Bartłomiej , Wojnar Piotr , Wolska-Pietkiewicz Małgorzata , Jędrzejewska Maria , Lewiński Janusz , Borysiewicz Michał A.
Published: September 2024

Zinc oxide (ZnO) is one of the most versatile semiconductor materials with many potential applications. Understanding the interactions between the surface chemistry of ZnO along with its physico-chemical properties are essential for the development of ZnO as a robust photocatalyst for the removal of aqueous pollutants. We report on the fabrication of nanoparticle-like porous ZnO films and the correlation between the fabrication process parameters, particle size, surface oxygen vacancies (SOV), photoluminescence and photocatalytic performance. The synthesis route is unique, as highly porous zinc layers with nanoscale grains were first grown via magnetron sputtering, a vacuum-based technique, and subsequently annealed at temperatures of 400 °C, 600 °C and 800 °C in oxygen flow to oxidise them to zinc oxide (ZnO) while maintaining their porosity. Our results show that as the annealing temperature increases, nanoparticle agglomeration increases, and thus there is a decrease in the active sites for the photocatalytic reaction. However, for selected samples the annealing leads to an increase of the photocatalytic efficiency, which we explain based on the analysis of defects in the material, based on photoluminescence (PL). PL analysis showed that in the material the transition between the conduction band and the oxygen vacancy is responsible for the green emission centered at 525 nm, but the photocatalytic activity correlated best with surface states—related emission.
Role of Systematic Biopsy in the Era of Targeted Biopsy: A Review
Authors: Malewski Wojciech , Milecki Tomasz , Tayara Omar , Poletajew Sławomir , Kryst Piotr , Tokarczyk Andrzej , Nyk Łukasz
Published: September 2024

Prostate cancer (PCa) is a major public health issue, as the second most common cancer and the fifth leading cause of cancer-related deaths among men. Many PCa cases are indolent and pose minimal risk, making active surveillance a suitable management approach. However, clinically significant prostate carcinoma (csPCa) can lead to serious health issues, including progression, metastasis, and death. Differentiating between insignificant prostate cancer (inPCa) and csPCa is crucial for determining appropriate treatment. Diagnosis of PCa primarily involves trans-perineal and transrectal systematic biopsies. Systematic transrectal prostate biopsy, which typically collects 10–12 tissue samples, is a standard method, but it can miss csPCa and is associated with some complications. Recent advancements, such as magnetic resonance imaging (MRI)-targeted biopsies, have been suggested to improve risk stratification and reduce overtreatment of inPCa and undertreatment of csPCa, thereby enhancing patient quality of life and treatment outcomes. Guided biopsies are increasingly recommended for their ability to better detect high-risk cancers while reducing identification of low-risk cases. MRI-targeted biopsies, especially when used as an initial biopsy in biopsy-naïve patients and those under active surveillance, have become more common. Utilization of MRI-TB alone can decrease septic complications; however, the combining of targeted biopsies with perilesional sampling is recommended for optimal detection of csPCa. Future advancements in imaging and biopsy techniques, including AI-augmented lesion detection and robotic-assisted sampling, promise to further improve the accuracy and effectiveness of PCa detection.
Intellectual Curiosity as a Mediator between Teacher–Student Relationship Quality and Emirati Science Achievement in PISA 2022
Authors: Ali Nagla , Abu Khurma Othman , Jarrah Adeeb
Published: September 2024

This study investigates the mediating role of intellectual curiosity (IC) in the relationship between teacher–student relationship quality (TSR) and science achievement among Emirati early adolescents. The objectives were to assess TSR’s predictive power on science achievement, evaluate IC’s impact on science achievement, examine the combined effect of TSR and IC, and investigate IC’s mediating role. Data from 17,475 valid cases in the PISA dataset were analyzed using Jeremy Hayes’ PROCESS macro, multiple regression models, and bootstrapping with 5000 resamples. The results indicated that TSR significantly and directly affects IC, which in turn positively influences science achievement. TSR’s direct effects on science achievement varied across cases, but IC consistently showed strong positive effects on science achievement, underscoring its critical role as a predictor of academic success. IC was found to significantly mediate the relationship between TSR and student performance. The findings suggest that enhancing both TSR and IC is essential for student success in science. The study’s implications for educational practices and policies include developing teacher training programs focused on building strong relationships with students and fostering intellectual curiosity through questioning and problem-solving. Specifically, educators should focus on skills and strategies for interacting with students, showing empathy, and forming strong relationships. Implementing ongoing practices that emphasize the intellectual aspects of learning can help students build curiosity, thereby improving their academic performance. The study provides valuable insights into the interactions between TSR and IC and their impact on students’ academic outcomes.
TransPVP: A Transformer-Based Method for Ultra-Short-Term Photovoltaic Power Forecasting
Authors: Wang Jinfeng , Hu Wenshan , Xuan Lingfeng , He Feiwu , Zhong Chaojie , Guo Guowei
Published: September 2024

The increasing adoption of renewable energy, particularly photovoltaic (PV) power, has highlighted the importance of accurate PV power forecasting. Despite advances driven by deep learning (DL), significant challenges remain, particularly in capturing the long-term dependencies essential for accurate forecasting. This study presents TransPVP, a novel transformer-based methodology that addresses these challenges and advances PV power forecasting. TransPVP employs a deep fusion technique alongside a multi-task joint learning framework, effectively integrating heterogeneous data sources and capturing long-term dependencies. This innovative approach enhances the model’s ability to detect patterns of PV power variation, surpassing the capabilities of traditional models. The effectiveness of TransPVP was rigorously evaluated using real data from a PV power plant. Experimental results showed that TransPVP significantly outperformed established baseline models on key performance metrics including RMSE, R2, and CC, underscoring its accuracy, predictive power, and reliability in practical forecasting scenarios.
Research Progress on Characteristics of Marine Natural Gas Hydrate Reservoirs
Authors: Yan Jiajia , Yan Kefeng , Huang Ting , Mao Minghang , Li Xiaosen , Chen Zhaoyang , Pang Weixin , Qin Rui , Ruan Xuke
Published: September 2024

As one of the most important future clean energy sources, natural gas hydrate (NGH) is attracting widespread attention due to the vast reserves available and high energy density. How to extract this source in a safe, efficient, and environmentally friendly manner has become the key to the commercial utilization of its resources. This paper reviews the recent advances in the study of the fundamental reservoir properties of offshore NGH, summarizing the methods and technologies for testing the sedimentary properties of reservoirs, analyzing the characteristics in reservoir mechanics, electrics, thermodynamics, and fluid dynamics, and discusses the influence of reservoir fundamental properties on NGH exploitation. The aim is to provide guidance and reference for research on the exploitation of NGH in different target exploitation areas offshore.
Optimization of Bi-LSTM Photovoltaic Power Prediction Based on Improved Snow Ablation Optimization Algorithm
Authors: Wu Yuhan , Xiang Chun , Qian Heng , Zhou Peijian
Published: September 2024

To enhance the stability of photovoltaic power grid integration and improve power prediction accuracy, a photovoltaic power prediction method based on an improved snow ablation optimization algorithm (Good Point and Vibration Snow Ablation Optimizer, GVSAO) and Bi-directional Long Short-Term Memory (Bi-LSTM) network is proposed. Weather data is divided into three typical categories using K-means clustering, and data normalization is performed using the minmax method. The key structural parameters of Bi-LSTM, such as the feature dimension at each time step and the number of hidden units in each LSTM layer, are optimized based on the Good Point and Vibration strategy. A prediction model is constructed based on GVSAO-Bi-LSTM, and typical test functions are selected to analyze and evaluate the improved model. The research results show that the average absolute percentage error of the GVSAO-Bi-LSTM prediction model under sunny, cloudy, and rainy weather conditions are 4.75%, 5.41%, and 14.37%, respectively. Compared with other methods, the prediction results of this model are more accurate, verifying its effectiveness.
Comparative and Descriptive Study of Biomass Gasification Simulations Using Aspen Plus
Authors: Loweski Feliz Minda , Abdelouahed Lokmane , Taouk Bechara
Published: September 2024

Biomass gasification has emerged as a promising method for producing renewable energy, addressing both energy and environmental challenges. This review examines recent research on gasification simulations, covering a range of topics from process modeling to syngas cleanup. Key areas explored include techniques for syngas cleaning, addressing tar formation, and CO2 capture methods. The aim of this review is to provide an overview of the current state of gasification simulation and identify potential areas for future research and development. This work serves as an invaluable resource for researchers, engineers, and industry professionals involved in biomass gasification modeling. By providing a comprehensive guide to biomass gasification simulation using Aspen Plus software and comparing various modeling approaches, it assists users in selecting the most effective tool for optimizing the design and operation of gasification systems.
Thermal–Mechanical Delamination for Recovery of Tempered Glass from Photovoltaic Panels
Authors: Surowiak Agnieszka , Wahman Mustapha
Published: September 2024

This paper presents a sustainable recycling process for the separation and recovery of tempered glass from end-of-life photovoltaic (PV) modules. As glass accounts for 75% of the weight of a panel, its recovery is an important step in the recycling process. Current methods, such as mechanical, chemical and thermal processes, often lead to contamination of the glass and pose significant environmental risks. In response to these challenges, a thermal–mechanical delamination approach is proposed in this study. The method utilizes controlled heat application (hot air gun) to weaken the adhesive bond between the glass and encapsulant, allowing for separation with a thin stainless steel wire. Various analytical methods, including X-ray diffraction analysis (XRD), X-ray fluorescence (XRF) and scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDS), were used to verify the effectiveness of the proposed method. The results show that the proposed method is effective. In less than a minute, the glass layer was separated and recovered with a success rate of over 99%, with no degradation of the material or release of gasses. The significance of this process lies in its ability to recover high-purity glass while minimizing the impact on the environment. This opens up the possibility of reusing the recovered tempered glass in new PV panels or other applications, reducing the need for virgin materials and lowering the overall environmental footprint of the solar energy industry.
Techno-Economic Analysis of Hybrid Renewable Energy Systems for Power Interruptions: A Systematic Review
Authors: Thango Bonginkosi A. , Obokoh Lawrence
Published: September 2024

The challenge of providing reliable electricity during power interruptions, especially in rural and remote regions, has prompted the exploration of Hybrid Renewable Energy Systems (HRESs). This systematic review employs the PRISMA framework to conduct a comparative analysis of HRES configurations, specifically those integrating rooftop solar photovoltaic (PV), diesel generators (DGs), converters, and battery energy storage systems (BESSs). This review assesses the techno-economic performance of these systems in various countries, highlighting the cost efficiency, reliability, and environmental impact compared to traditional single-resource systems. The analysis reveals that HRESs offer significant advantages in managing energy supply during power interruptions, particularly in regions with high solar potential but unreliable grid access. A comparative analysis with other countries demonstrates that while HRES configurations are tailored to local conditions, the integration of solar PV with diesel generators is a consistently effective strategy across different contexts. This review provides essential insights for policymakers and stakeholders, facilitating the optimization of energy solutions tailored to regional needs.
A Swap-Body Vehicle Routing Problem Considering Fuel Consumption Management and Multiple Vehicle Trips
Authors: Peng Yong , Zhang Yali , Yu Dennis Z. , Liu Song , Li Yuanjun , Shi Yangyan
Published: September 2024

The swap-body vehicle routing problem (SBVRP) represents a specialized extension of the traditional vehicle routing problem (VRP), incorporating additional practical complexities. Effective fuel consumption management and the scheduling of multiple vehicle trips are pivotal strategies for reducing costs and ensuring the sustainability of distribution systems. In response to the acceleration of urbanization, the rising demand for logistics, and the deteriorating living environment, we introduce an SBVRP considering fuel consumption and multiple trips to enable greener, cheaper, and more efficient delivery methods. To tackle the SBVRP, we propose a hybrid multi-population genetic algorithm enhanced with local search techniques to explore various areas of the search space. Computational experiments demonstrate the efficiency of the proposed method and the effectiveness of its components. The algorithm developed in this study provides an optimized solution to the VRP, focusing on achieving environmentally friendly, sustainable, and cost-effective transportation by reducing energy consumption and promoting the rational use of resources.
Children’s Clothing in a Picture: Explorations of Photography, Childhood and Children’s Fashions in Early 20th Century Greece and Its US Diaspora
Authors: Dounia Margarita
Published: September 2024

Children’s dress is a constituent element of individual and group identity as well as an indicator of social change. Exploring childhood in three Greek rural communities in Laconia, Kythera, and Crete as well as in their respective diaspora in the United States, this study aims at shedding light on the (re)presentation of children in photographic records through clothing, perceived as the material projection on the self and the group (familial, ethnic, transnational). Drawing from theoretical and methodological approaches of distinct fields, such as history, fashion, photography, material and visual studies, and social anthropology, the study explores dynamic changes and shifting meanings in the way children were perceived and projected or asserted themselves through tangible sources, namely photographs, and clothing. The time period examined spans from the 1900s to the late 1930s without rigidly defining, as shifts witnessed in this time period were occurring in the last years of the 19th century, while the aftermath of the 1930s recession years could be felt beyond the period under study.
Evaluating Parental Knowledge and Behaviors Regarding Developmental Toxicants in Jazan, Saudi Arabia Using the Prevention of Toxic Chemicals in the Environment for Children Tool (PRoTECT)
Authors: Alqassim Ahmad Y.
Published: September 2024

This study evaluated the level of knowledge among parents in Jazan, Saudi Arabia, regarding substances that can harm child development. The Prevention of Toxic Chemicals in the Environment for Children Tool (PRoTECT) was used for this assessment. A cross-sectional survey using a multi-stage cluster random sampling approach was undertaken among 424 parents who were enlisted from eight primary healthcare centers (PHCCs). The PRoTECT score’s median value was 72 out of 90, suggesting a generally high level of awareness. The study found that individuals with higher education, particularly those with postgraduate degrees, had greater awareness of protecting their children’s health. Interestingly, unemployed individuals and those residing in mountainous areas also demonstrated higher awareness, possibly due to having more time to focus on their children’s health and well-being. Most participants (68.2%) acknowledged the correlation between exposure to toxic chemicals during pregnancy and early childhood, and the subsequent development of neurodevelopmental disorders. The study found a solid foundation of knowledge, with 85.1% of participants interested in learning more about reducing children’s exposure, but it also stressed the need for specific actions to turn awareness into prevention. These findings would help policymakers develop effective strategies, such as targeted educational campaigns, collaboration with healthcare providers, utilization of media channels, and encouragement of community-led initiatives, to reduce children’s exposure to developmental toxicants in line with national and global environmental health initiatives. Future research should focus on longitudinal consciousness and behavior evaluations and regional environmental contaminants.
Mucopolysaccharidosis-Plus Syndrome: Is This a Type of Mucopolysaccharidosis or a Separate Kind of Metabolic Disease?
Authors: Cyske Zuzanna , Gaffke Lidia , Pierzynowska Karolina , Węgrzyn Grzegorz
Published: September 2024

Several years ago, dozens of cases were described in patients with symptoms very similar to mucopolysaccharidosis (MPS). This new disease entity was described as mucopolysaccharidosis-plus syndrome (MPSPS). The name of the disease indicates that in addition to the typical symptoms of conventional MPS, patients develop other features such as congenital heart defects and kidney and hematopoietic system disorders. The symptoms are highly advanced, and patients usually do not survive past the second year of life. MPSPS is inherited in an autosomal recessive manner and is caused by a homozygous-specific mutation in the gene encoding the VPS33A protein. To date, it has been described in 41 patients. Patients with MPSPS exhibited excessive excretion of glycosaminoglycans (GAGs) in the urine and exceptionally high levels of heparan sulfate in the plasma, but the accumulation of substrates is not caused by a decrease in the activity of any lysosomal enzymes. Here, we discuss the pathomechanisms and symptoms of MPSPS, comparing them to those of MPS. Moreover, we asked the question whether MPSPS should be classified as a type of MPS or a separate disease, as contrary to ‘classical’ MPS types, despite GAG accumulation, no defects in lysosomal enzymes responsible for degradation of these compounds could be detected in MPSPS. The molecular mechanism of the appearance of GAG accumulation in MPSPS is suggested on the basis of results available in the literature.
Body Composition and Alzheimer’s Disease: A Holistic Review
Authors: Frank Giulia , Gualtieri Paola , Cianci Rossella , Caldarelli Mario , Palma Roselisa , De Santis Gemma Lou , Porfilio Chiara , Nicoletti Francesco , Bigioni Giulia , Di Renzo Laura
Published: September 2024

Alzheimer’s disease (AD) represents a significant global health challenge and affects approximately 50 million people worldwide. This overview of published reviews provides a comprehensive understanding of the intricate correlations between AD and body composition, focusing particularly on obesity. We used a systematic approach to collect and analyze relevant reviews on the topic of obesity and Alzheimer’s disease. A comprehensive search of electronic databases, including PubMed, MEDLINE, and Google Scholar, was conducted. We searched keywords such as “Alzheimer’s disease”, “body composition”, “lean mass”, “bone mass”, and “fat mass”. We considered only reviews written within the past 5 years and in English. Fifty-six relevant reviews were identified that shed light on the multiple connections between AD and body composition. The review involves several aspects, including the impact of lean mass, bone mass, and endocrinological factors related to obesity, as well as inflammation, neuroinflammation, and molecular/genetic factors. The findings highlight the complex interplay of these elements in the development of AD, underscoring the need for holistic approaches to reduce the risk of AD and to explore innovative strategies for diagnosis, prevention, and treatment.
The Role of Host Genetics and Intestinal Microbiota and Metabolome as a New Insight into IBD Pathogenesis
Authors: Zakerska-Banaszak Oliwia , Zuraszek-Szymanska Joanna , Eder Piotr , Ladziak Karolina , Slomski Ryszard , Skrzypczak-Zielinska Marzena
Published: September 2024

Inflammatory bowel disease (IBD) is an incurable, chronic disorder of the gastrointestinal tract whose incidence increases every year. Scientific research constantly delivers new information about the disease and its multivariate, complex etiology. Nevertheless, full discovery and understanding of the complete mechanism of IBD pathogenesis still pose a significant challenge to today’s science. Recent studies have unanimously confirmed the association of gut microbial dysbiosis with IBD and its contribution to the regulation of the inflammatory process. It transpires that the altered composition of pathogenic and commensal bacteria is not only characteristic of disturbed intestinal homeostasis in IBD, but also of viruses, parasites, and fungi, which are active in the intestine. The crucial function of the microbial metabolome in the human body is altered, which causes a wide range of effects on the host, thus providing a basis for the disease. On the other hand, human genomic and functional research has revealed more loci that play an essential role in gut homeostasis regulation, the immune response, and intestinal epithelial function. This review aims to organize and summarize the currently available knowledge concerning the role and interaction of crucial factors associated with IBD pathogenesis, notably, host genetic composition, intestinal microbiota and metabolome, and immune regulation.
Cystic Fibrosis: A Journey through Time and Hope
Authors: Trouvé Pascal , Saint Pierre Aude , Férec Claude
Published: September 2024

Just over thirty years is the span of a generation. It is also the time that has passed since the discovery of the gene responsible for cystic fibrosis. Today, it is safe to say that this discovery has revolutionized our understanding, research perspectives, and management of this disease, which was, thirty years ago, a pediatric condition with a grim prognosis. The aim of this review is to present the advances that science and medicine have brought to our understanding of the pathophysiology of the disease and its management, which in many ways, epitomizes modern molecular genetic research. Since the discovery of the cystic fibrosis transmembrane conductance regulator (CFTR) gene in 1989, modeling the CFTR protein, deciphering its function as an ion channel, and identifying its molecular partners have led to numerous therapeutic advances. The most significant advancement in this field has been the discovery of protein modulators that can target its membrane localization and chloride channel activity. However, further progress is needed to ensure that all patients can benefit from a therapy tailored to their mutations, with the primary challenge being the development of treatments for mutations leading to a complete absence of the protein. The present review delves into the history of the multifaceted world of CF, covering main historical facts, current landscape, clinical management, emerging therapies, patient perspectives, and the importance of ongoing research, bridging science and medicine in the fight against the disease.
Methamphetamine Increases Tubulo-Vesicular Areas While Dissipating Proteins from Vesicles Involved in Cell Clearance
Authors: Lazzeri Gloria , Lenzi Paola , Busceti Carla L. , Puglisi-Allegra Stefano , Ferrucci Michela , Fornai Francesco
Published: September 2024

Cytopathology induced by methamphetamine (METH) is reminiscent of degenerative disorders such as Parkinson’s disease, and it is characterized by membrane organelles arranged in tubulo-vesicular structures. These areas, appearing as clusters of vesicles, have never been defined concerning the presence of specific organelles. Therefore, the present study aimed to identify the relative and absolute area of specific membrane-bound organelles following a moderate dose (100 µM) of METH administered to catecholamine-containing PC12 cells. Organelles and antigens were detected by immunofluorescence, and they were further quantified by plain electron microscopy and in situ stoichiometry. This analysis indicated an increase in autophagosomes and damaged mitochondria along with a decrease in lysosomes and healthy mitochondria. Following METH, a severe dissipation of hallmark proteins from their own vesicles was measured. In fact, the amounts of LC3 and p62 were reduced within autophagy vacuoles compared with the whole cytosol. Similarly, LAMP1 and Cathepsin-D within lysosomes were reduced. These findings suggest a loss of compartmentalization and confirm a decrease in the competence of cell clearing organelles during catecholamine degeneration. Such cell entropy is consistent with a loss of energy stores, which routinely govern appropriate subcellular compartmentalization.
The Facile Production of p-Chloroaniline Facilitated by an Efficient and Chemoselective Metal-Free N/S Co-Doped Carbon Catalyst
Authors: Villora-Picó Juan-José , Gil-Muñoz Gema , Sepúlveda-Escribano Antonio , Pastor-Blas M. Mercedes
Published: September 2024

The catalytic hydrogenation of the toxic and harmful p-chloronitrobenzene to produce the value-added p-chloroaniline is an essential reaction for the sustainable chemical industry. Nevertheless, ensuring satisfactory control of its chemoselectivity is a great challenge. In this work, a N/S co-doped metal-free carbon catalyst has been fabricated by using cysteine as a source of C, N, and S. The presence of calcium citrate (porogen agent) in the mixture subjected to pyrolysis provided the carbon with porosity, which permitted us to overcome the issues associated with the loss of heteroatoms during an otherwise necessary activation thermal treatment. Full characterization was carried out and the catalytic performance of the metal-free carbon material was tested in the hydrogenation reaction of p-chloronitrobenzene to selectively produce p-chloroaniline. Full selectivity was obtained but conversion was highly dependent on the introduction of S due to the synergetic effect of S and N heteroatoms. The N/S co-doped carbon (CYSCIT) exhibits a mesoporous architecture which favors mass transfer and a higher doping level, with more exposed N and S doping atoms which act as catalytic sites for the hydrogenation of p-chloronitrobenzene, resulting in enhanced catalytic performance when compared to the N-doped carbon obtained from melamine and calcium citrate (MELCIT) used as a reference.
Bias-Reduced Haebara and Stocking–Lord Linking
Authors: Robitzsch Alexander
Published: September 2024

Haebara and Stocking–Lord linking methods are frequently used to compare the distributions of two groups. Previous research has demonstrated that Haebara and Stocking–Lord linking can produce bias in estimated standard deviations and, to a smaller extent, in estimated means in the presence of differential item functioning (DIF). This article determines the asymptotic bias of the two linking methods for the 2PL model. A bias-reduced Haebara and bias-reduced Stocking–Lord linking method is proposed to reduce the bias due to uniform DIF effects. The performance of the new linking method is evaluated in a simulation study. In general, it turned out that Stocking–Lord linking had substantial advantages over Haebara linking in the presence of DIF effects. Moreover, bias-reduced Haebara and Stocking–Lord linking substantially reduced the bias in the estimated standard deviation.
Angiopoietin-like Proteins and Lipoprotein Lipase: The Waltz Partners That Govern Triglyceride-Rich Lipoprotein Metabolism? Impact on Atherogenesis, Dietary Interventions, and Emerging Therapies
Authors: Gugliucci Alejandro
Published: September 2024

Over 50% of patients who take statins are still at risk of developing atherosclerotic cardiovascular disease (ASCVD) and do not achieve their goal LDL-C levels. This residual risk is largely dependent on triglyceride-rich lipoproteins (TRL) and their remnants. In essence, remnant cholesterol-rich chylomicron (CM) and very-low-density lipoprotein (VLDL) particles play a role in atherogenesis. These remnants increase when lipoprotein lipase (LPL) activity is inhibited. ApoCIII has been thoroughly studied as a chief inhibitor and therapeutic options to curb its effect are available. On top of apoCIII regulation of LPL activity, there is a more precise control of LPL in various tissues, which makes it easier to physiologically divide the TRL burden according to the body’s requirements. In general, oxidative tissues such as skeletal and cardiac muscle preferentially take up lipids during fasting. Conversely, LPL activity in adipocytes increases significantly after feeding, while its activity in oxidative tissues decreases concurrently. This perspective addresses the recent improvements in our understanding of circadian LPL regulations and their therapeutic implications. Three major tissue-specific lipolysis regulators have been identified: ANGPTL3, ANGPTL4, and ANGPTL8. Briefly, during the postprandial phase, liver ANGPTL8 acts on ANGPTL3 (which is released continuously from the liver) to inhibit LPL in the heart and muscle through an endocrine mechanism. On the other hand, when fasting, ANGPTL4, which is released by adipocytes, inhibits lipoprotein lipase in adipose tissue in a paracrine manner. ANGPTL3 inhibitors may play a therapeutic role in the treatment of hypertriglyceridemia. Several approaches are under development. We look forward to future studies to clarify (a) the nature of hormonal and nutritional factors that determine ANGPTL3, 4, and 8 activities, along with what long-term impacts may be expected if their regulation is impaired pharmacologically; (b) the understanding of the quantitative hierarchy and interaction of the regulatory actions of apoCIII, apoAV, and ANGPTL on LPL activity; (c) strategies for the safe and proper treatment of postprandial lipemia; and (d) the effect of fructose restriction on ANGPTL3, ANGPTL4, and ANGPTL8.
Recommender Systems and Over-the-Top Services: A Systematic Review Study (2010–2022)
Authors: Vicente Paulo Nuno , Burnay Catarina Duff
Published: September 2024

Artificial intelligence (AI) technologies have been increasingly developed and applied in the audiovisual sector. Over-the-top (OTT) services, directly distributed to viewers via the Internet, are associated with a shift towards automation through algorithmic mediation in audiovisual content led by digital platforms. However, scientific knowledge regarding algorithmic recommender systems and automation in OTT services is not yet systemized; researchers, practitioners, and the public thus lack full awareness about the still largely opaque phenomena. To address this gap, we conduct a systematic literature review in the communication domain (2010–2022) and answer four key research questions: What research objectives have been pursued? What concepts have been developed and/or applied? What methodologies have been privileged? Which OTT platforms have received the most research attention? Challenges and opportunities are highlighted, and an agenda for future research is advanced.
Application of Microbiological Screening Tests in Assessment of Environmental Exposure to Antibiotics: Preliminary Studies
Authors: Madej-Knysak Daria , Adamek Ewa , Kośmider Leon , Baran Wojciech
Published: September 2024

Contact of aquatic microbiocenoses with antibiotics present in the environment can cause the former to develop resistance to antimicrobial drugs. Therefore, the search for methods to detect antibiotics and drug-resistant microorganisms in the environment is important. The presented paper proposes a simple procedure to assess environmental exposure to antibiotics and the presence of non-susceptible microorganisms. Medium solutions with selected antibiotics and a microbial growth indicator were applied to test plates, and were inoculated with water samples from various ecosystems. After incubation, the susceptibility of the microorganisms to antibiotics was determined and presented in chronic microbial toxic concentration (MTC) values. It was confirmed that the presented procedure enables the assessment of the antibiotic susceptibility and adaptation potential of unselected microorganisms from different aquatic ecosystems. However, the MTC values depend on the inoculum volume, the density and seasonal activity of the microorganisms, the method of inoculum preparation, and the incubation time of the test plate. The described procedure may be practically applied as a screening test to identify the presence of drug-resistant microorganisms. Additionally, it may also be suitable as a method to assess environmental exposure to antibiotics. However, prior standardisation is required before implementing this procedure in quantitative studies.
Assessment of Urban Green Space Dynamics in Dhaka South City Corporation of Bangladesh Using Geospatial Techniques
Authors: Misty Maliha Sanzana , Hoque Muhammad Al-Amin , Mukul Sharif A.
Published: September 2024

Green spaces play a critical role in enhancing the urban environment, improving livability, and providing essential ecosystem services. A city should have at least 25% green space from an environmental and health point of view. However, quantitative estimation is required to assess the extent and pattern of green space changes for proper urban management. The present study aimed to identify and track the changes in urban green spaces within the Dhaka South City Corporation (DSCC) of Bangladesh over a 30-year period (i.e., 1991–2021). Geospatial techniques were utilized to analyze green space dynamics using Landsat 4–5 TM satellite images from 1991, 2001, and 2011 and Landsat 8 images from 2021. Supervised image classification techniques and Normalized Difference Vegetation Index (NDVI) analysis were performed to assess the urban green space dynamics in DSCC. The results of our study revealed a significant 36.5% reduction in vegetation cover in the DSCC area over the study period. In 1991, the green area coverage in DSCC was 46%, indicating a relatively healthy environment. By 2001, this coverage had declined sharply to 21.3%, further decreasing to 19.7% in 2011, and reaching a low of just 9.5% in 2021. The classified maps generated in the study were validated through field observations and Google Earth images. The outcomes of our study will be helpful for policymakers and city planners in developing and applying appropriate policies and plans to preserve and improve urban green spaces in DSCC in Bangladesh and other Asian megacities with high population density.
Effect of Grazing on Plant and Soil Parameters of Steppe Pastures on Mount Aragats, Armenia
Authors: Navasardyan Marine , Sargsyan Tatevik , Daveyan Harutyun , Mezhunts Bagrat , Abraham Eleni M.
Published: September 2024

Steppe pastures are characteristic of the Armenian landscape and play an important role in supporting livelihoods and biodiversity conservation. The productivity and biodiversity of steppe pastures depend on grazing management, soil types, and climatic and topographical characteristics. As a whole, they form local small-scale sites. Our data on five study sites located on the southeast slope of Mt. Aragats summarized the impact of sites and grazing on canopy height; productivity; grass, legume, and forb biomass; nitrogen, phosphorus, and potassium concentrations; pH; and litter contents in the soil. Five grazed and ungrazed plots (ca. 600–800 m2) were established at each study site. Within each plot, two permanent 40 m long transects were installed. The canopy height was recorded in ungrazed and freely grazed plots. The aboveground biomass was cut at the soil surface from May to June; grouped into grass, legumes, and forbs; dried; and weighed. Soil samples were collected in every ungrazed and freely grazed plot. The results indicated that grazing decreased the plant parameters and nitrogen and litter content across all sites, while it had no effect on the phosphorus and potassium content or the pH. It seems that plant parameters, as well as soil parameters, were more affected by the management strategy than by the topographical and climatic features of the sites, as revealed via redundancy analysis. Our results suggest that it is important to introduce livestock rotation practices for sites with respect to the sustainable management of steppe pastures. This management strategy could ensure ecosystem services, high forage quality, and soil fertility.