bluuebunny/crossref_metadata_2025 huggingface dataset:
Development and Evaluation of Implant using Hot-Melt Extrusion
Authors:   The Pharmaceutical Society Of Korea, Lee Soo Hwan , Lee Geun Nyeong , Kim Young Jin , Cho Young Ho , Lee Gye Won
Published: March 2023

In this study, poly(lactic-co-glycolic acid) (PLGA)-based subcutaneous implant containing metformin HCl was prepared by hot-melt extrusion (HME). This study aimed to evaluate swelling and dissolution behavior for application as subcutaneous implant. Implants containing metformin HCl were fabricated successfully at 30 rpm, 90oC by HME. Drugexcipient compatibility studies through FT-IR and DSC revealed the absence of any interaction between the drug and polymers. Dissolution rate and swelling ratio of metformin HCl was significantly affected by the type of PLGA. Dissolution rate increased as the ratio of -COOH terminal group and GA. By the results, we could confirm that the mechanism of drug release from implants is Korsmeyer-Peppas model (n=0.14~0.71) by combination of non-fickian diffusion and erosion. The formulation F7 with 65% of RG 752H and 5% of RG 502 was showed excellent swelling ratio with drug release control. In this study, mixing 5~10% of RG 502 with RG 752H can be expected to develop optimal implants exhibiting diffusion-controlled release for 3 months without initial burst release.
Cynara scolymus L. Inhibits the LPS-induced Inflammatory Reaction via Suppression of NF-κB Activity in RAW 264.7 Cells
Authors:   The Pharmaceutical Society Of Korea, Boo Kyung-Jun , Lee Kiman , Park Il-Ho , Kang Tae Jin
Published: March 2023

Cynara scolymus L. (artichoke) has been traditionally used in the treatment of digestive-related disease, severe hyperlipidemia and liver disease. Recently, anti-inflammatory effect of artichoke has been reported by several studies, but its mechanisms are still unclear. In this study, the anti-inflammatory mechanism of artichoke was studied using an in vitro acute inflammation model. The effect of artichoke on the expression of pro-inflammatory cytokines, such as interleukin- 1beta (IL-1β), IL-6, and tumor necrosis factor-alpha (TNF-α) in murine macrophage cell line, RAW264.7, was examined by using ELISA and RT-PCR. As a result, artichoke inhibited the expression of IL-1β, IL-6 and TNF-α in macrophages activated by lipopolysaccharide (LPS) at a dose dependent manner. The expression of inflammatory mediators such as NO and PGE2 was next investigated in RAW264.7 cells stimulated with LPS. Artichoke also inhibited the production of NO and PGE2 in the cells at a dose dependent manner. Artichoke suppressed the mRNA expression of iNOS and COX-2 in macrophages by LPS. The effect of artichoke on the activation of NF-κB was examined and LPS-induced NF-κB activation was decreased by treatment of artichoke, suggesting that artichoke has anti-inflammatory effect by inhibiting NF- κB activation.
Effect of Savinin to Inhibit RANKL-induced Osteoclast Differentiation
Authors:   The Pharmaceutical Society Of Korea, Shin Han-Byeol , Lee Yongjin , Lee Mina , Son Young-Jin
Published: March 2023

Osteoporosis is a disease in which bone density is decreased and fractures occur easily due to external environment. The treatment of osteoporosis is important to prevent bone loss and to suppress the formation of osteoclasts involved in bone resorption. Osteoclasts, which are multinucleated cells, are greatly increased and overactivated in bone diseases including osteoporosis and rheumatoid arthritis. In this study, the effect of savinin on osteoclast differentiation by RANKL was investigated. Savinin significantly inhibited RANKL-induced osteoclast differentiation by inhibiting the transcriptional and translational expression of NFATc1, an essential component of RANKL-mediated osteoclast formation. In addition, mRNA expressions of OSCAR, DC-STAMP, and CTSK related to osteoclast differentiation and function were suppressed. Inhibition of osteoclast activity was verified through bone resorptive assay. Therefore, it is confirmed that savinin inhibits osteoclast differentiation, so it has the potential to be used as a therapeutic agent for the treatment of osteoporosis.
Study And Modeling of Question Answer System Using Deep Learning Technique of AI
Authors: Ranjan Amit , Yadav Rakesh Kumar , Tewari Gaurav
Published: March 2023

In this paper, the different QA system types, the theoretical foundation for deep learning models, the metaheuristic optimization techniques, and the performance assessment metrics are discussed. A suggested architecture for a question-and-answer system that takes a deep learning approach is shown here. The study also covers the constraints and factors to take into account regarding the aforementioned system.
Cloud Service Selection System Approach based on QoS Model: A Systematic Review
Authors: Swathi V N V L S , Kumar G Senthil , Vathsala A. Vani
Published: March 2023

The Internet of Things (IoT) has received a lot of interest from researchers recently. IoT is seen as a component of the Internet of Things, which will include billions of intelligent, talkative "things" in the coming decades. IoT is a diverse, multi-layer, wide-area network composed of a number of network links. The detection of services and on-demand supply are difficult in such networks, which are comprised of a variety of resource-limited devices. The growth of service computing-related fields will be aided by the development of new IoT services. Therefore, Cloud service composition provides significant services by integrating the single services. Because of the fast spread of cloud services and their different Quality of Service (QoS), identifying necessary tasks and putting together a service model that includes specific performance assurances has become a major technological problem that has caused widespread concern. Various strategies are used in the composition of services i.e., Clustering, Fuzzy, Deep Learning, Particle Swarm Optimization, Cuckoo Search Algorithm and so on. Researchers have made significant efforts in this field, and computational intelligence approaches are thought to be useful in tackling such challenges. Even though, no systematic research on this topic has been done with specific attention to computational intelligence. Therefore, this publication provides a thorough overview of QoS-aware web service composition, with QoS models and approaches to finding future aspects.
A Study on Port (Terminals) Operational Efficiency Analysis Using PCA-DEA Approach: Focusing on Container Terminals on Busan Port
Authors:   The Korean Logistics Research Association, Zhou Lele , Lee Hyang-Sook
Published: March 2023

Previous literature has recognised the importance of port efficiency to port performance, and two popular methodologies of DEA (Data Envelopment Analysis) and SFA (Stochastic Frontier Analysis) have been widely applied to efficiency evaluation. However, there seems a limitation of lacking objectivity when selecting the variables of inputs and outputs. Meanwhile, as for the largest port in Korea, although many related efficiency studies already exist for Busan Port, most of them are founded on a whole port level basis while seldom on the container terminal level. Therefore, to fill the gap, this paper introduces a PCA (Principal Component Analysis) - DEA approach to research the operational efficiency of nine container terminals of Busan Port with the latest data of 2021. The PCA-DEA port (terminal) evaluation approach is practical and unbiased, and it may have some special practical value for the port industry. Container throughput is set as the output, and 13 variables from three scopes of land, facilities and labour are identified as inputs, followed by PCA which eventually detects three indictors of “No. transfer crane (RMGC) in yard”, “Staff average salary” and “Container freight station (CFS) space” as the core inputs representing the above three dimensions. Then, the DEA (CCR) and DEA (BCC) models are used to gain the assessment results: “PNIT, “PNC” and “HJNC” are DEA efficiency, while others of “HPNT”, “BNCT”, “Jaseongdae”, “Shinseondae”, “Gamman” and “Shin Gamman” are non-DEA efficiency. In addition, to achieve the target efficiency for the non-effective terminals, this paper confirms improvements through Return to Scale (ROS) and input redundancy discussion. This study objectively evaluates port terminals and provides useful data when establishing strategies to strengthen port efficiency and competitiveness in the future.
Using the Methodology Problem-Based Learning to Teaching Programming to Freshman Students
Authors:   the Federal University Technology of Parana (UTFPR), Ponta Grossa-PR, Brazil, Aires João Paulo , Aires Simone Bello Kaminski , Pereira Maria João Varanda , Alves Luis Manuel
Published: March 2023

This work registers the initial results of a teaching strategy implemented with students entering the Algorithms discipline with a higher degree in Computing. This discipline offered to first-year students records cases of dropout and evasion. Thus, it is necessary to implement teaching strategies to provide engagement, interest, and motivation with the subjects worked on. The main objective is apply an active methodology problem-based learning in programming teaching. In this work participated 177 students in the years 2019-2 (47), 2020-1/2020-2 (83), and 2021-2 (47), enrolled in the first period of the course. The methodology adopted for the development of this study consisted of: use of questionnaires to measure prior knowledge about computing concepts; group discussion of the answers recorded in the questionnaire; development of an APP for smartphone; use of the PBL (Problem-based learning) methodology as a learning strategy. It is an activity related to the active teaching and learning methodology of problem-based learning that is being developed on the first day of class in groups of up to five students. The strategy consisted of two actions: 1) answering a questionnaire associating everyday computing elements; and 2) even though the programming concepts were not presented, the groups were challenged to develop a smartphone application. Each group received a questionnaire containing 19 questions divided into four blocks. What can be seen from the completion of this work was the enthusiasm, motivation, and engagement of the students, who, even though they were newcomers, organized themselves into groups and researched the necessary strategies to complete the challenge. When measuring the knowledge obtained through the application of a questionnaire relating to the content (with the participation of 62% of students), it was found that 81% of the participants obtained the necessary grade for approval of that content. Following the strategy of an active methodology of learning and teaching that favors the protagonism and autonomy of the student, we concluded that strategy was benefic for to the students, and the teacher acted as a guide in the teaching process, directing what should be researched to find the solution and serving as a tutor in the resolution of the problem presented. Preliminarily, part of this study was presented at the 2nd International Computer Programming Education Conference.
The Effect of Digital Technology Learning Based on Guided Discovery and Self-regulated Learning Strategy on Mathematical Creativity
Authors:   Universitas Negeri Jakarta, Indonesia, Hidajat Flavia Aurelia , Haeruman Leny Dhianti , Wiraningsih Eti Dwi , Pambudi Didik Sugeng
Published: March 2023

Considering that teachers can not directly supervise or control students’ real activities during online learning, students need to manage their learning without the teacher’s presence. However, students cannot manage their learning process independently and tend to do other activities during the online learning process. On the other hand, students need to combine previous knowledge to form new and creative ideas. This contradictory condition causes students not to focus on learning, students are not able to combine previous knowledge, and there is no effort to form new and creative ideas. So students’ mathematical creativity is very low. As a result, teachers must implement strategies that guide students to find new or creative ideas by activating students’ self-regulation abilities during online learning. This study applied digital technology learning through the LMS (learning management system) based on guided discovery and self-regulated learning strategies to overcome these problems. This research employed the quantitative research method. The subjects of this study were 67 high school students in Malang. The sampling technique was the distribution of the questionnaire. The data were first tested to gain normality by using the Kolmogorov Smirnov test. Data analysis employed multiple-linear regression tests. Meanwhile, the data analysis process employed the SPSS-23 application. The results show that digital learning technology based on guided discovery and self-regulated learning strategies positively affects students’ mathematical creativity during online learning. The higher implementation of digital technology learning based on guided discovery and self-regulated learning strategies will improve students’ mathematical creativity. This research provides information to develop learning for educators. using Digital technology learning based on guided discovery and self-regulated learning strategies, guided discovery-based digital technology learning, and independent learning strategies have increased students’ mathematical creativity.
Effectiveness Project-Based Learning in ESP Class: Viewed from Indonesian Students‘ Learning Outcomes
Authors:   the Faculty of Letters, English Language Education, State University of Malang, Indonesia, Hidayati Dewi , Novianti Hartia , Khansa Maharani , Slamet Joko , Suryati Nunung
Published: March 2023

The use of Project-Based Learning (PjBL), as a teaching strategy, is on the rise across the country because it is considered as a means to make learning more interesting for students and to emphasize the acquisition of skills essential for success in the modern workplace. In order to cater to the needs of its students, English for Specific Purposes (ESP) necessitates interdisciplinary expertise due to its unique qualities. As a result, the position of the educator shifts significantly from that of the typical language instructions to the subject matter being taught. The purpose of this study was to investigate whether or not using PjBL in ESP class improves students’ overall learning outcomes. In this particular investigation, a single group pre-test and post-test experimental design was utilized, and the participants included 40 samples that were selected on purpose. When it came to the students’ video projects, the use of PjBL led to a significant improvement in the learning outcomes that were achieved. The findings indicated high mean scores on the learning outcomes subscales that were investigated, in addition to positive correlations on the academic performance of the participants. These results may add to the growing body of literature on the topic of how best to teach and learn ESP across disciplines by integrating different approaches and methods.
Mucormycosis—A significant hazard in the COVID-19 pandemic?
Authors: Pranave P  , Kshirsagar Rajesh , Sardeshmukh Amruta , Sinha Rinisha , Kumar Gaurav , Kedia Daksh
Published: March 2023

Mucormycosis was the third most common angio-invasive fungal infection after candidiasis and aspergillosis. However, the frequency of this disease seems to be increasing with the arrival of COVID-19 infection. Despite efforts to better understand the pathophysiology of mucormycosis, its fatality rate remains high. Therefore, this review article aims to accomplish an evidence-based review answering whether mucormycosis is a significant hazard in the era of COVID-19 infection. It contains a wealth of information about the infection's aggressive and deadly characteristics in diabetic and immunocompromised individuals, as well as its pathogenesis, clinical aspects, and management, along with its link to COVID-19, which is the need of the hour.

The method used to assemble all the information was a review of the literature, along with multiple case reports supporting the occurrence of COVID-19 linked mucormycosis. 

This article concludes that uncontrolled diabetes mellitus in COVID-19 patients makes them more vulnerable to secondary infections, primarily mucormycosis, due to the over-zealous use of corticosteroids for its treatment, resulting in immunosuppression. The diagnosis and treatment of this black fungus have also been established to be quite challenging. 

The effective management of mucormycosis in immunocompromised individuals is centered on a multimodal approach that includes early diagnosis, or cessation of the primary prompting factors, administration of antifungal agents at ideal doses, and comprehensive amputation of all devitalized tissues, along with several adjunctive remedies.
A retrospective study – Pattern of maxillofacial injuries in government dental college and hospital Aurangabad, Marathvada region
Authors: Gavali Pankajkumar , Landge Jayant S , Shah Kanchan M , Choudhary Yashpal , Lahoti Amol
Published: March 2023

Government dental college and hospital in Aurangabad, India's state of Maharashtra. Traffic accidents were found to be the most common cause of facial fractures (55.1%), with a male preponderance and a peak incidence between the ages of 20 and 30. The most frequent type of fractures were isolated mid-face fractures (586 patients; 24.05%), followed by isolated mandibular fractures (1257 patients; 51.6%). The zygomatic bone and arch were most frequently involved in midface fractures. The majority of the time, closed reduction and internal fixation were used instead of open reduction and internal fixation. According to the study's findings, traffic accidents are the main reason for maxillofacial fractures. Every citizen is required to enforce and abide by laws that establish preventative measures.
The basic assembly of skeletal models in the fall detection problem
Authors:   Tula State University, Seredin O.S. , Kopylov A.V. ,   Tula State University, Surkov E.E. ,   Tula State University, Huang S.-C. ,   National Taipei University of Technology
Published: March 2023

The paper considers the appliance of the featureless approach to the human activity recognition problem, which exclude the direct anthropomorphic and visual characteristics of human figure from further analysis and thus increase the privacy of the monitoring system. A generalized pairwise comparison function of two human skeletal models, invariant to the sensor type, is used to project the object of interest to the secondary feature space, formed by the basic assembly of skeletons. A sequence of such projections in time forms an activity map, which allows an application of deep learning methods based on convolution neural networks for activity recognition. The proper ordering of skeletal models in a basic assembly plays an important role in secondary space design. The study of ordering of the basic assembly by the shortest unclosed path algorithm and correspondent activity maps for video streams from the TST Fall Detection v2 database are presented.
High-Q tunable Fano resonances in the curved waveguide resonator with mirrors with spatially variable reflectivity
Authors:   IACP FEB RAS, Dyshlyuk A.V. ,   Far Eastern Federal University,   Vladivostok State University of Economics and Service, Vitrik O.B. ,   IACP FEB RAS,   Far Eastern Federal University
Published: March 2023

High-Q Fano resonances are demonstrated, as well as effects similar to electromagnetically induced transparency arising in a curved Fabry-Perot waveguide resonator with variable-reflection mirrors. It is shown that these effects arise as a result of coupling the fundamental mode of the bent waveguide core with whispering gallery cladding modes. An influence of the main geometrical parameters of the resonator on the resonance features in its reflection and transmission spectra is studied. The results obtained can be used in the creation of new functional elements of photonics based on curved waveguides, in particular, highly sensitive portable refractometers for bio- and chemosensory systems, as well as optical sensors of mechanical effects.
Method for copyright protection of deep neural networks using digital watermarking
Authors:   Samara National Research University, Vybornova Y.D.
Published: March 2023

The article proposes a new method of copyright protection for deep neural networks. The main idea of the method is to embed digital watermarks into the protected model by retraining it on a unique set of pseudo-holographic images (pseudo-holograms). A pseudo-hologram is a two-dimensional sinusoidal signal that encodes a binary sequence of arbitrary length. By changing the phase of each sinusoid, it is possible to form various pseudo-hologram images based on a single bit sequence. The proposed approach to embedding is to generate a training sample in such a way that pseudo-holograms formed on the basis of one sequence fall into the same class. In this case, each class will correspond to different bit sequences. Verification of the digital watermark is carried out by applying various pseudo-holograms to the input of the model and checking whether the hidden sequence corresponds to a certain class. Experimental studies confirm the efficiency of the method and its compliance with all quality criteria established for the methods of neural network watermarking.
Impact of DEHP Toxicity on Testis of Rat Leading to Disruption of Testis Histology
Authors: Gouri Kumari , Sinha Preety
Published: March 2023

Di (2-ethyl hexyl) Phthalate (DEHP) is one of the plasticizers widely used in the manufacturing of plastics to make it flexible and durable. Present study is focussed to observe the deleterious effects of DEHP on male reproductive system of animals. For this, 1000 mg/kg body wt. of DEHP was administered to different groups of male Wistar rat for 2, 4, 6 and 8 weeks. After each interval, rats were sacrificed and histological alterations in testis of rats were observed. On hormonal assay, testosterone level decreased significantly in DEHP exposed groups. The histological structure of the testis was also observed to be disrupted significantly with increasing duration of DEHP exposure. Organisation of seminiferous tubule was found distorted and disoriented showing large gaps between them along with degenerated epithelium. Evident changes in morphology of spermatozoa were seen with gradual loss of head and tail structure. Decrease in the number of Leydig cells and sertoli cells were also found suggesting DEHP as a potent toxicant for male reproductive system.
The Guardians of the Sea : Echinoderms as Sentinels of Marine Pollution
Authors: Garcês Andreia , Pires Isabel
Published: March 2023

Every year tons of heavy metals, plastic, pesticides, industrial chemicals, and sewage reach the oceans. Many of these compounds are not biodegradable and have a prolonged half-life, occurring and causing effects even several years after application. The consequences are diverse as biomagnification of toxins, infertility, neoplasia, hormonal alteration, or malformations. Sentinel species can be barometers for current or potential negative impacts on individuals, animal populations and ecosystem health, helping to identify hidden risks to human health and predict future changes. Several bioindicators allow us to evaluate the status of ecosystems, echinoderms are some of them. Their diversity of habitats, diet, sensibility to changes in the environment and position of the trophic chain makes them one the most ideal marine sentinels. This paper aims to present a summarized review with the latest information available that is related to the echinoderms as a sentinel of human, animal and environmental health.
Fluoride Contamination, Toxicity and its Potential Therapeutic Agents
Authors: Rajak Prem , Roy Sumedha , Khatun Salma , Mandi Moutushi , Ganguly Abhratanu , Das Kanchana , Dutta Anik , Nanda Sayantani , Ghanty Siddhartha , Biswas Gopal
Published: March 2023

Fluoride is the thirteenth most abundant element in the earth’s crust. It is highly electronegative and distributed ubiquitously in nature. During weathering of rocks and soil, fluoride can leach out and dissolve in the groundwater. Both plants and animals are exposed to several compounds of fluoride through contaminated soil and water. Fluoride contamination in groundwater is a major global concern as groundwater is frequently used for drinking in various parts of the world, especially in developing countries. Fluoride compounds have been reported to impose acute and chronic health hazards. Millions of global populations are suffering from dental and skeletal fluorosis due to high fluoride intake through drinking water. In green vegetation, fluoride accumulation causes necrosis in the tip and marginal portions of leaves. Diverse detrimental effects of fluoride on health have insisted researchers globally to identify compounds having protective potential against fluoride toxicity. Several plant extracts, vitamins, polyphenols, melatonin, hypophyseal proteins, and lycopene have been demonstrated to enhance the antioxidant status and subvert fluoride-induced health hazards in model organisms. However, more studies are required to forward conclusive opinions in terms of the real-life efficacy of these antioxidants against fluoride toxicity.
Inverse Spectral Problems for Weighted Graphs
Authors: Pylypiva Oleksandra , Tymoshkevych Larysa
Published: March 2023

The paper is devoted to inverse spectral problems for weighted graphs. We give the sharp upper bound for spectral reconstruction number of trees and unicyclic graphs.
Research of Stochastic Behaviour of Cellular Automata
Authors: Hlushenkov Serhii , Chornei Ruslan
Published: March 2023

A wide range of complex systems with local interactions could be described by cellular automata. Despite the fact, that in general, behaviour of each cellular automata on its own could be quite simple, their effective combination, or setting unusual interaction rules may result in extraordinary system with much more complicated behaviour, or unexpected and ambiguous observation results. Stochasticity in interactions between cells approximates simulated environment to real conditions and helps finding optimal strategy, which would be more stable under all circumstances and events, especially unlikely ones. Stochastic cellular automata are often used for modelling natural phenomena and processes, simulating traffic flows, cryptography, and so on. Finding an optimal strategy – is a key problem in managing environments with available outside influence.This article shows existence of optimal strategies for stochastic cellular automata systems, gives an example of applying improving strategy algorithm in case of extinguishing forest fires, analyses chosen strategy optimality.
Speech Audio Modeling by Means of Causal Moving Average Equipped Gated Attention
Authors: Ivaniuk Andrii
Published: March 2023

In the paper we compare different attention mechanisms on the task of audio generation using unsupervised approaches following previous work in language modeling. It is important problem, as far as speech synthesis technology could be used to convert textual information into acoustic waveform signals. These representations can be conveniently integrated into mobile devices and used in such applications as voice messengers or email apps. Sometimes it is difficult to understand and read important messages when being abroad. The lack of appropriate computer systems or some security problems may arise. With this technology, e-mail messages can be listened quickly and efficiently on smartphones, boosting productivity. Apart from that, it is used to assist visually impaired people, so that, for instance, the screen content can be automatically read aloud to a blind user. Nowadays, home appliances, like slow cookers can use this system too for reading culinary recipes, automobiles for voice navigation to the destination spot, or language learners for pronunciation teaching. Speech generation is the opposite problem of automatic speech recognition (ASR) and is researched since the second half of the eighteen's century. Also, this technology also helps vocally handicapped people find a way to communicate with others who do not understand sign language. However, there is a problem, related to the fact that the audio sampling rate is very high, thus leading to very long sequences which are computationally difficult to model. Second challenge is that speech signals with the same semantic meaning can be represented by a lot of signals with significant variability, which is caused by channel environment, pronunciation or speaker timbre characteristics. To overcome these problems, we train an autoencoder model to discretize continuous audio signal into a finite set of discriminative audio tokens which have a lower sampling rate. Subsequently, autoregressive models, which are not conditioned on text, are trained on this representation space to predict the next token, based on previous sequence elements. Hence, this modeling approach resembles causal language modeling. In our study, we show that unlike in the original MEGA work, traditional attention outperforms moving average equipped gated attention, which shows that EMA gated attention is not stable yet and requires careful hyper-parameter optimization.
BR 230
Authors: Freitas André Luis Pereira de
Published: March 2023

ResumoEste texto versa sobre uma série de fotografias tiradas em duas viagens que fiz na BR 230, a Transamazônica. São impressões e relatos da experiência como professor colaborador do curso intercultural Indígena da Universidade do Estado do Pará e outra viagem como professor da Secretaria de Estado de Educação – Seduc, onde fui coordenador de mídia no Projeto denominado Sistema Educacional Interativo – SEI. É um texto, portanto, que versa sobre arte, educação, tecnologia e sobre questões prementes que impactam sobre a região amazônica, sua diversidade, patrimônio e a história de suas populações, em especial aqui, uma comunidade da etnia Munduruku e os colonos que povoa a Transamazônica. Pessoas que foram atraídos do nordeste e sul do Brasil com a propaganda de “integrar para não entregar”. Mas integrar o que pra quem? Para não entregar o que pra quem?AbstractThis text is about a series of photographs taken on two trips I took on the BR 230, the Transamazônica. These are impressions and reports of the experience as a collaborating professor of the Indigenous intercultural course at the State University of Pará and another trip as a professor at the State Secretariat of Education - Seduc, where I was the media coordinator in the Project called Sistema Educacional Interativo - SEI. It is therefore a text that deals with art, education, technology and pressing issues that impact on the Amazon region, its diversity, heritage and the history of its populations, especially here, a community of the Munduruku ethnic group and the settlers that inhabit the Transamazônica region. People who were attracted from the northeast and south of Brazil with the “integrate not to deliver” advertisement. But integrating what for whom? Not to deliver what to whom?
OLHARES CRUZADOS: UMA INTERFACE ENTRE CINEMA E MUSEU
Authors: Costa Luiz Tadeu da
Published: March 2023

ResumoO texto visa elaborar uma reflexão entre o cinema e o museu no que tange às transformações ocorridas nos dois campos desde o séc. XX. Nessa análise vamos usar algumas teorias do cinema, assim como da museologia. Esse cruzamento teórico pode facilitar a percepção das diferenças e semelhanças entre os dois campos.AbstractThe text aims to elaborate a reflection between the cinema and the museum regarding the transformations that have taken place in both fields since the 20th century. In this analysis we will use some theories of cinema, as well as museology. This theoretical intersection can facilitate the perception of differences and similarities between the two fields.
Competencias convergentes de los estudiantes: experiencia educativa con futuros diseñadores industriales e ingenieros mecánicos
Authors: Lino Alves Jorge , Alexandre Rui , Lopes Lígia
Published: March 2023

Desde la cultura académica y empresarial se sabe que los productos de diseño, de gran impacto en la sociedad, surgen en su mayoría de una ‘receta’ que cuenta con aportes de otras áreas y habilidades científicas, a saber, la ingeniería mecánica. Sin embargo, durante el proceso de enseñanza-aprendizaje de las carreras de Diseño Industrial e Ingeniería Mecánica, no es habitual que estas habilidades se mezclen antes de llegar a la vida profesional. Este estudio de caso realizado en la Universidad de Oporto muestra precisamente esta experiencia.
Development and Nutritional Profiling of Commonly Used and Underutilized Vegetables Incorporated Instant Powders
Authors: Prasoona J. , Kumari B. Anila , Sarkar Supta , Kiran V. Kavitha , Swamy R.
Published: March 2023

Background: Presently, due to changing in life style of the people and desire for more leisure time, there is considerable change in food habits with a strong demand for processed food products. This trend has also resulted in huge demand for processed vegetables in markets for use in convenience foods, dry salad mixes, dehydrated soups, pizzas, etc. Interestingly, the literature on utilization of vegetables for preparation of chutney powder is not available. Thus, there exists a need to develop suitable technology for the development of vegetable based instant chutney powder that will not only check the losses but also generate additional revenue for the growers. Methods: The work was done in the year 2019-2020. The vegetables were collected from the local market at Rajendranagar of Telangana state. After the preliminary processing, the vegetables were blanched and with different formulations 3 best selected powders were analyzed. Result: The results of the study found that addition of vegetables and underutilized green leafy vegetables improved the sensory quality, protein, crude fiber, in incorporated instant chutney powder than the control sample.
Palynological zonation of the Givetian-Frasnian stratigraphic interval in the Timan-Northern Urals region
Authors: Tel'nova O. , Shumilov I.
Published: March 2023

The zonal scheme of the Givetian-Frasnian boundary interval in the Timan-Northern Urals region was detailed according to the higher plants spores. Palynological zones were correlated with faunal, including conodont — orthostratigraphic group in the Devonian. The correlation of the identified critical boundaries in the development of plant communities with the divisions’ borders of the International Stratigraphic Scale — series and stages, were established and options for the level of the border of the Middle and Upper Devonian in the regional stratigraphic scheme of the new generation were considered.
Prevalence Rate of Thalassemia Carriers among Individuals with Microcytosis or Hypochromia in Portugal
Authors: Santos Daniela , Barreto Marta , Kislaya Irina , Mendonça Joana , P. Machado Miguel , Lopes Pedro , Matias Dias Carlos , Faustino Paula
Published: March 2023

Introduction: Microcytosis and hypochromia result from deficient hemoglobin synthesis in red blood cells and are easily detected in a complete blood count test. These conditions are mainly due to iron nutritional deficiency, but may also result from some genetic diseases, such as thalassemia. The aim of this study was to determine the contribution of β- and α-thalassemia to these abnormal hematological phenotypes in a representative sample of adult individuals living in Portugal who participated in the first Portuguese National Health Examination Survey (INSEF).Methods: Among the 4808 INSEF participants, 204 had microcytosis, hypochromia or both. The corresponding 204 DNAs were screened for changes in the β-globin gene by next-generation sequencing and Sanger sequencing. In addition, α-thalassemia deletions within the α-globin cluster were investigated by Gap-PCR and multiplex ligation-dependent probe amplification.Results: In this selected subgroup of INSEF participants, 54 had α-thalassemia (26%), predominantly caused by the -α3.7kb deletion, and 22 were β-thalassemia carriers (11%) mainly due to point mutations in the β-globin gene previously known in Portugal.Conclusion: Thalassemia trait is a frequent cause of microcytosis or hypochromia in Portugal since this genetic condition was found in 37% of the investigated cases.
Health Center Utilization among the Elderly in the East Java Province
Authors: Megatsari Hario , Nandini Nurhasmadiar , Laksono Agung Dwi
Published: March 2023

Background: According to WHO, the elderly is one of the vulnerable groups apart from children and pregnant women. This study aims to analyze the factors related to health center utilization among the elderly in East Java. Methods: This study analyzed secondary data from the Indonesia Basic Health Survey 2018. Using the stratification method and multistage random sampling, this study recruited 25,034 elderly people in East Java as samples. In addition to health center utilization as the dependent variable, residence, age, gender, marriage, education, occupation, socioeconomics, insurance, and travel time to a health center were analyzed as independent variables. Data were analyzed using binary logistic regression. Results: The results found that age was related to health center utilization. Elderly men had 0.874 times more probability than elderly women to use health centers (OR 0.874; 95% CI 0.869-0.879). Marital, education, occupation, and socioeconomic, were also found to be significantly related to health center utilization. The elderly who had health insurance managed by the government had a 1.883 times higher probability than the elderly who did not have health insurance to make use of health center services, while other types of insurance had a lower probability. Based on the travel time to health centers, the elderly who had a travel time of 10 minutes or less were 1.099 times more likely than the elderly who had a travel time of >10 minutes to use health centers (OR 1.099; 95% CI 1.094-1.105). Conclusion: Seven variables had a relationship with health center utilization among the elderly in East Java; age, gender, marriage, education, occupation, insurance, and travel time to health centers. Policymakers can use the research results to determine specific targets to accelerate the increase in health center utilization for the elderly in East Java.
The Impact of Covid-19 Social Isolation on Mental Health and Physical Activity of Older Adults
Authors: Kistiana Sari
Published: March 2023

Background: The ongoing COVID-19 pandemic tends to affect older adults more severely, raising the need for social isolation in this age population. Social isolation is likely to impact older adults’ social ties and quality of life, as well as the risk for illness and health. Objective: This study is a narrative literature review to evaluate the potential effects of social isolation on the mental health and well-being of older adults. Methods: A literature search performed between January 1, 2020, and January 13, 2021, comprised an electronic search on different online databases in PubMed and ScienceDirect using the keywords COVID-19 followed by generic terms older adults or older people or aging population or elderly. Excluding duplicates, a total of 376 articles were screened, of which 21 studies were included in the final review. Results: Many older people could be mentally well-equipped to deal with social isolation, but some experience a negative impact on mental health. Stress, anxiety, and depression symptoms were reported during the self-isolation period. Physical activity also has declined among older adults amid COVID-19. Some elderly who are not moving much may lose significant muscle strength, flexibility, and aerobic capacity. Conclusion: If social isolation continues, policy responses such as proactively identifying and addressing COVID-19 for the elderly who are experiencing negative consequences. An effective solution such as “distance connectivity” and creating safe physical activity such as home exercise is recommended.
Autonomy of High-Risk Pregnant Women in an Effort to Prevent Complications during Childbirth
Authors: Nafikadini Iken , Anggi Eka Septiani  , Ragil Ismi Hartanti
Published: March 2023

Background: Maternal mortality is a health problem that has not been resolved until now. Based on data from January-September 2020 from the Public Health Center of Panti District, most pregnant women with high risk are those who have a risk of preeclampsia. Pregnant women have an important role and personal autonomy in decision-making during the process of pregnancy. Objective: To analyze the autonomy of high-risk pregnant women to prevent complications during childbirth. Methods: Qualitative research with a case study approach. Determination of the main informants using a purposive technique consisted of five pregnant women at risk of preeclampsia who were under 20 years old and above 35 years old. Data collection using in-depth interview guide and documentation. Data analysis using inductive thematic analysis. Results: intentions, affordability of information, situations in preparing blood donors, and maternity funds can form the negative autonomy of high-risk pregnant women in decision-making. Husband’s social support can form positive autonomy of high-risk pregnant women in decision making. High-risk pregnant women have negative autonomy in choosing a place for maternity care to practice as a midwife even though they have been advised to carry out routine checks at the primary healthcare. High-risk pregnant women have negative autonomy in choosing the place of delivery by not changing their choice and making the primary healthcare or hospital the second and last choice. Conclusion: The autonomy of high-risk pregnant women has formed a negative autonomy in making decisions about childbirth planning and preventing complications.
The Effect of Attitudes, Subjective Norms, and Perceptions of Behavioral Control on Pregnancy Check-ups in Bojonegoro
Authors: Ulfah Mariya , Anggraeni Sri
Published: March 2023

Background: In Indonesia, the use of antenatal care services has not been carried out according to standards. According to WHO, 99% of maternal deaths are due to the lack of information for pregnant women about the importance of regular prenatal check-ups. Objective: This study aims to examine the relationship strength between attitudes, subjective norms, and perceptions of behavioral control regarding antenatal care with the intention of pregnant women in conducting early pregnancy check-ups (K1) using a quantitative approach with a cross-sectional study design. Methods: The population in this study were 234 pregnant women who had their first antenatal contact with K1 at the Dander Health Center in Bojonegoro Regency, which was collected from March to August 2020. Probability sampling utilizing a basic random sample methodology was employed. Furthermore, 129 pregnant women were used as samples for this study. Data is collected in the form of primary data through a questionnaire, while the secondary data were analyzed using logistic regression. The dependent variable is the intention of pregnancy check-ups, while the independent variables are attitudes, subjective norms, and perceptions. Results: The results showed that there was a relationship between the attitude of pregnant women (p=0.001) and subjective norms (p=0.038) regarding pregnancy check-ups with the intention of pregnant women to visit K1 (α=0.05). However, there was no relationship between perceptions of behavioral control regarding antenatal care and the intention of pregnant women to visit K1 (p=0.142). Conclusion: The findings revealed an association between pregnant women's attitudes and subjective norms about prenatal care and their intention to attend K1. This study suggests that pregnant women’s knowledge needs to be improved, including through classes about the importance of good subjective attitudes and norms related to antenatal care to support the intention to check pregnancy regularly especially K1 visits. As a result, early and regular pregnancy check-ups will detect high-risk pregnancies so that they can be handled immediately, thereby reducing maternal and infant mortality.
Pengembangan LKPD Digital Berorientasi Nature of Science dan Berbantuan PhET Interactive Simulation pada Materi Gerak Harmonik Sederhana
Authors: Mahendra Zhenk Eka , Purwana Unang , Liliawati Winny
Published: March 2023

Penelitian ini bertujuan untuk mengembangkan dan menganalisis kelayakan LKPD digital berorientasi nature of science dan berbantuan PhET Interactive Simulation. Penelitian ini menggunakan metode penelitian dan pengembangan dengan model ADDIE. Partisipan penelitian ini terdiri dari 4 orang validator dan 32 peserta didik kelas X SMA. Instrumen yang digunakan dalam penelitian ini berupa lembar validasi LKPD, lembar wawancara semi terstruktur, dan angket respon peserta didik. Berdasarkan data hasil validasi LKPD didapatkan indeks validitas Aiken sebesar 0,83 dengan kategori validitas tinggi.  Respon yang diberikan peserta didik sangat positif dengan rata-rata persentase hasil respon sebesar 87,31%. Penilaian LKPD digital mendapatkan hasil rata-rata nilai sebesar 85,85 yang termasuk ke dalam kategori baik. Dengan demikian, LKPD digital berorientasi nature of science dan berbantuan PhET Interactive Simulation pada materi gerak harmonik sederhana sangat layak untuk digunakan dalam pembelajaran dan dapat digunakan sebagai sumber belajar mandiri oleh peserta didik. This study aims to develop and determine the feasibility of the nature of science-oriented digital student worksheets and is assisted by PhET Interactive Simulation. This study uses research and development methods with the ADDIE model. The subjects of this study consisted of 4 validators and 32 students of class X senior high school. The instruments used in this study were student worksheets, validation sheets, semi-structured interview sheets, and student response questionnaires. Based on the student worksheets validation results data, Aiken’s validation index is 0.83, with a high validity category. The responses given by students were very positive, with an average percentage of response results of 87,31%. The digital student worksheets assessment got an average score of 85.85, which included a good category. Thus, digital worksheets oriented to the nature of science and assisted by PhET Interactive Simulation on simple harmonic motion material are very suitable for learning and can be used as a source of independent learning by students.
Association of funding and conflicts of interest on outcomes reported in published studies of Covid-19
Authors: Gajbhiye Snehalata , Chindhalore Chaitali , Gupta Ashish , Dakhale Ganesh
Published: March 2023

Background: An outbreak of the Covid-19 has led to substantial mortality globally. The entire world is carrying out studies to understand the pathophysiology, clinical features, diagnosis and treatment of Covid-19. We investigated the possible association of type of funding, corporate or academic, and conflict of interests on the outcomes reported in clinical trials on Covid-19. Methods: Studies containing the keywords “clinical trial” AND “Covid 19” or “Corona” were located by a search on PubMed published between September 2019 to August 2021. Filters were used to select only papers in the English language and on “humans”. The data were analysed using descriptive statistics and the Chi-square test. Results: We found a significant association between the existence of a conflict of interest and reporting of a positive outcome (X2 value = 18.751, p<0.001). We also found a significant association between industry funding and reporting of a positive outcome (X2 value = 18.041, p<0.001). Conclusion: We conclude from this study that the presence of conflict of interest and pharmaceutical industry funding is associated with reporting a positive outcome.