bluuebunny/crossref_metadata_2025 huggingface dataset:
Chromosome 9 Inversion: Pathogenic or Benign?
A Comprehensive Systematic Review of all Clinical Reports
Authors: Mohsen-Pour Neda , Talebi Taravat , Naderi Niloofar , Moghadam Maryam Hosseini , Maleki Majid , Kalayinia Samira
Published: August 2021

Background:

Inversion of chromosome 9 (inv[9]) is known as one of the most
common structural balanced chromosomal variations. Chromosome 9 is highly
susceptible to structural rearrangements, specifically to pericentric inversions. Various
investigators have posited that inv(9) with different breakpoints could be the cause of
several abnormal conditions in individuals, whereas others have considered it a benign
variant. To our knowledge, a consensus regarding the effects of this inversion has yet to
emerge.

Objective:

This study aims to discuss the pathogenic/benign effects of inv(9) in all
possible clinical conditions detected in the occurrence of this abnormality.

Methods:

Studies on inv(9) were collected via PubMed, MalaCards, Google Scholar,
and NORD, along with the search terms of inv(9), pericentric inv(9), and chromosome 9
variants. Additionally, the incidence of inv(9) and the karyotype and clinical findings of
individuals reported with this variant were investigated.

Results:

The collection of the studies reviewed shows that inv(9) is associated with
various conditions such as congenital anomalies, growth retardation, infertility, recurrent
pregnancy loss, and cancer. The clinical features associated with this variant in humans
vary between growth stages. Further, there have been no shared clinical findings in a
specific period.

Conclusions:

Although there is no conclusive evidence for the pathogenicity of this
rearrangement, prenatal genetic counseling on inv(9) and further clinical and molecular
studies would be helpful in chromosome 9-related problems.
Effect of Consumption of a Mediterranean Herb Crocus sativus L. (Saffron) on Health Aspects: Evidence and Prospects
Authors: Gupta Ena , Singh Priyanka , Mishra Neha , Devi Suman
Published: August 2021

Crocus sativus L. (Saffron) is a Mediterranean herb of the Iridaceae family. The
dried stigmas of C. sativa plant are processed to produce well-known spice saffron rich in secondary
metabolites (safranal, crocetin, terpenes, crocins, picrocrocin, kaempferol and quercetin)
with a wide range of important biological activities in curing many human diseases.
Around the world, saffron is considered to be the most expensive spice, with an estimated annual
production of around 300 tons per year. Therapeutic efficacies of saffron are proved
through pharmacological studies and it is considered as a promising candidate with potentials
for designing new drugs. In different food supplements, saffron is mainly used due to its antioxidant
properties, intense flavour, aroma and luminous yellow-orange hue. Worldwide it is
used in everything from confectioneries, liquors, cheeses, curries, soups, baked goods and meat
dishes. This review is aimed to summarize the ethnomedicinal importance, phytochemistry and
acceptable daily intake with a wide spectrum of pharmacological and therapeutic applications
of saffron.
Design and Synthesis of Novel Ibuprofen Derivatives as Selective COX-2
Inhibitors and Potential Anti-Inflammatory Agents: Evaluation of PGE2,
TNF-α, IL-6 and Histopathological Study
Authors: El-Nassan Hala Bakr , Halim Peter Amir , El-Dash Yara Sayed
Published: August 2021

Background:

The reported binding mode of ibuprofen in the COX-2 binding site indicated
that the carboxylic group binds with Arg-120 and Tyr-355 at the entrance of the cyclooxygenase
channel and does not extend into the pocket. This accounted for the non-selectivity of ibuprofen.
Based on this fact, we assumed that extending the length of the carboxylic acid moiety in ibuprofen
and adding more bulky rigid groups as well as bulky groups carrying H-bonding functions might
increase the selectivity and reduce the side effects of ibuprofen while maintaining its analgesic and
anti-inflammatory activities.

Objective:

In this work, four series of ibuprofen derivatives were designed and prepared. The compounds
were designed by increasing the length of the carboxylate group along with the incorporation
of large hydrophobic groups.

Method:

Four series of ibuprofen derivatives were synthesized starting from ibuprofen. Their chemical
structure was confirmed by spectral data. All the compounds were tested for their COX inhibitory
activity.

Results :

The best COX-2 activity and selectivity were obtained with compounds 5c and 5d, which
were subjected to further in vivo testing (carrageenan-induced paw edema, rat serum PGE2, TNF- α
and IL-6, hot plate latency test) to investigate their anti-inflammatory and analgesic activities as well
as their effects on the gastric mucosa. The anti-inflammatory activity of both compounds was comparable
to that of ibuprofen, diclofenac, and indomethacin. Both compounds suppressed the production
of PGE2 as well as the rat serum concentrations of both TNF-α and IL-6. This potent antiinflammatory
and analgesic behavior was not accompanied by any effect on the gastric mucosa.
Docking simulation studies of the two compounds explained the higher selectivity for the COX-2
enzyme.

Conclusion:

Potent and selective ibuprofen derivatives can be successively obtained by extending
the length of the carboxylic acid moiety in ibuprofen and adding more bulky rigid groups as well as
bulky groups with H-bonding functions.
Effects of N224 Glycosylation in Saccharomycopsis fibuligera R64
α-Amylase on Enzyme Activity and Stability
Authors: Sugijo Yovin , Rosahdi Tina Dewi , Puspasari Fernita , Ismaya Wangsa Tirta , Hasan Khomaini , Ihsanawati  , Subroto Toto , Natalia Dessy
Published: August 2021

Background:

The amino acid sequence of an α-amylase of the yeast Saccharomycopsis fibuligera
R64 (SfamyR64) contains two putative N-linked glycosylation sites N153 and N224. N224 is hypothetically
responsible for the binding of starch substrate because it is highly conserved among SfamyR64
homologs.

Objective:

To test whether N224 plays a key role in enzyme activity and stability.

Methods:

N224Q substitution was introduced by site-directed mutagenesis. The wild type and the mutant
were independently over-produced in Pichia pastoris KM71. Activities of the wild type and of the mutant
were compared, and their thermal-stability was assessed using heat treatments. The evolutionary relationship
of SfamyR64 with its structural homologs with different glycosylation patterns was examined.

Results:

Activity of the N224Q mutant was approximately 80% lower than that of the wild type. The mutant
showed no activity after 10 min of pre-incubation at 50 °C, whereas the wild type SfamyR64 showed
activity until 30 min of treatment. Sfamy appeared to have evolved earlier than its structural homolog.

Conclusion:

SfamyR64 N224 is crucial for enzyme activity and thermal stability. This glycosylation
site is unique for fungal and bacterial α-amylases.
Prefrontal Cortex Transcranial Direct Current Stimulation Treatment in
Alcohol Dependence Syndrome (PreCoTTA): Study Protocol for a Double-
blind Randomized Sham-controlled Trial
Authors: Deshmukh Anagha S. , Praharaj Samir Kumar , Rai Shweta , Kamath Asha , Upadhya Dinesh
Published: August 2021

Background:

Alcohol dependence is a significant public health problem, contributing to
the global health burden. Due to its immense socio-economic burden, various psychosocial, psychological,
and pharmacological approaches have attempted to alter the behaviour of the patient misusing
or abusing alcohol, but their efficacy is modest at best. Therefore, there is a search for newer
treatment approaches, including non-invasive brain stimulation in the management of alcohol dependence.
We plan to study the efficacy of Prefrontal Cortex Transcranial direct current stimulation
Treatment in Alcohol dependence syndrome (PreCoTTA).

Methods:

Two hundred twenty-five male patients with alcohol dependence syndrome will be randomized
into the three study arms (2 active, left dorsolateral prefrontal cortex and left orbitofrontal
cortex, and 1 sham) to receive a total of 14 tDCS sessions (10 continuous and 4 booster sessions).
Data will be collected from these sessions at five different time points on clinical, neuropsychological
and biochemical parameters. In addition, 225 healthy age and education matched controls will
be administered the neuropsychological test battery at baseline for comparison with the patient
group.

Discussion:

The proposed study aims to explore the use of non-invasive brain stimulation; tDCS
as a treatment alternative. We also aim to overcome the methodological gaps of limited sample
sizes, fewer tDCS intervention sessions, lack of long-term follow-ups to measure the sustainability
of gains, and lack of comprehensive measures to track changes in functioning and abstinence after
tDCS intervention. The main outcomes include clinical (reduction in cue-induced craving, time to
first drink, and QFI); neuropsychological (risk-taking, impulsivity, and other neuropsychological
domains), and biochemical markers (BDNF, leptin and adiponectin). The findings of the study will
have translational value as they may help to improve the clinician’s ability to effectively manage
craving in patients with alcohol dependence syndrome. Furthermore, we will have a better understanding
of the neuropsychological and biochemical effects of non-invasive brain stimulation techniques
which are of interest in the comprehensive treatment of addiction disorders.

Trial registration:

The study has been registered with the Clinical Trials Registry-India (CTRI/
2020/09/027582) on September 03rd 2020.
A Comparison Analysis for Protein-Protein Interaction Network-Based
Methods in Prioritizing Arabidopsis Functional Genes
Authors: Si Chun-Jing , Deng Si-Min , Quan Yuan , Zhang Hong-Yu
Published: August 2021

Background: Connecting genes to phenotypes is still a great challenge in genetics. Research
related to gene-phenotype associations has made remarkable progress recently due to high-throughput
sequencing technology and genome-wide association study (GWAS). However, these genes, which are
considered to be significantly associated with a target phenotype according to traditional GWAS, are
less precise or subject to greater confounding.

Objective: The present study is an attempt to prioritize functional genes for complex phenotypes employing
protein-protein interaction (PPI) network-based systems genetics methods on available GWAS
results.

Methods: In this paper, we calculated the functional gene enrichment ratios of the trait ontology of A.
thaliana for three common systems genetics methods (i.e. GeneRank, K-shell and HotNet2). Then,
comparison of gene enrichment ratios obtained by PPI network-based methods was performed. Finally,
a hybrid model was proposed, integrating GeneRank, comprehensive score algorithm and HotNet diffusion-
oriented subnetworks (HotNet2) to prioritize functional genes.

Results: These PPI network-based systems genetics methods were indeed useful for prioritizing
775henoltype-associated genes. And functional gene enrichment ratios calculated from the top 20% of
GeneRank-identified genes were higher than these ratios of K-shell and these ratios of HotNet2 for most
phenotypes. However, the hybrid model can improve the efficiency of functional gene enrichment for A.
thaliana (up to 40%).

Conclusion: The present study provides a hybrid method integrating GeneRank, comprehensive score
algorithm and HotNet2 to prioritize functional genes. The method will contribute to functional genomics
in plants. The source data and codes are freely available at http://47.242.161.60/Plant/.
Potential Therapeutic Benefits of Sodium-Glucose Cotransporter 2 Inhibitors
in the Context of Ischemic Heart Failure: A State-of-the-Art Review
Authors: Gitto Mauro , Vrachatis Dimitrios A. , Condorelli Gianluigi , Papathanasiou Konstantinos , Reimers Bernhard , Deftereos Spyridon , Stefanini Giulio G
Published: August 2021

:

Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a class of anti-diabetic agents
that block the reabsorption of glucose in the proximal convoluted tubule of the nephron, thereby
contributing to glycosuria and lowering blood glucose levels. SGLT2 inhibitors have been associated
with improved cardiovascular outcomes in patients with diabetes, including a reduced risk of
cardiovascular death and hospitalizations for heart failure. Recently, DAPA-HF and EMPEROR
REDUCED trials showed the beneficial cardiovascular effect of SGLT2 inhibitors in patients with
heart failure with consistently reduced ejection fraction (HFrEF) regardless of the presence of diabetes.
Moreover, some exploratory studies suggested that these drugs improve Left Ventricular
(LV) systolic function and oppose LV adverse remodeling in patients with HFrEF. However, the
exact mechanisms that mediated for this benefit are not fully understood. Beyond glycemic control,
enhanced natriuresis, increased erythropoiesis, improved endothelial function and changes in myocardial
metabolism may all play an active role in SGLT2 inhibitors’ cardiovascular benefits. A
deep understanding of the pathophysiological interplay is key to define which HF phenotype could
benefit more from SGLT2 inhibitors. Current evidence on the comparison of different HF etiologies
is limited to posthoc subgroup analysis of DAPA-HF and EMPEROR-REDUCED, which
showed similar outcomes in patients with or without ischemic HF. On the other hand, in earlier
studies of patients suffering from diabetes, rates of classic ischemic endpoints, such as myocardial
infarction, stroke or coronary revascularization, did not differ between patients treated with SGLT2
inhibitors or placebo. The aim of this review is to discuss whether SGLT2 inhibitors may improve
prognosis in patients with ischemic HF, not only in terms of reducing re-hospitalizations and improving
LV function but also by limiting coronary artery disease progression and ischemic burden.
Drosophila: A Model to Study the Pathogenesis of Parkinson’s Disease
Authors: Rahul  , Siddique Yasir Hasan
Published: August 2021

:

Human Central Nervous System (CNS) is the complex part of the human body, which regulates multiple cellular and molecular events taking place simultaneously. Parkinsons Disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease (AD). The pathological hallmarks of PD are loss of dopaminergic neurons in the substantianigra (SN) pars compacta (SNpc) and accumulation of misfolded α-synuclein, in intra-cytoplasmic inclusions called Lewy bodies (LBs). So far, there is no cure for PD, due to the complexities of molecular mechanisms and events taking place during the pathogenesis of PD. Drosophila melanogaster is an appropriate model organism to unravel the pathogenicity not only behind PD but also other NDs. In this context as numerous biological functions are preserved between Drosophila and humans. Apart from sharing 75% of human disease-causing genes homolog in Drosophila, behavioral responses like memory-based tests, negative geotaxis, courtship and mating are also well studied. The genetic, as well as environmental factors, can be studied in Drosophila to understand the geneenvironment interactions behind the disease condition. Through genetic manipulation, mutant flies can be generated harboring human orthologs, which can prove to be an excellent model to understand the effect of the mutant protein on the pathogenicity of NDs.
Are Lysosomes Potential Therapeutic Targets for Parkinson’s Disease?
Authors: Petese Alessandro , Cesaroni Valentina , Cerri Silvia , Blandini Fabio
Published: August 2021

Background:

Parkinson´s disease (PD) is the second most common neurodegenerative
disorder, affecting ~2-3% of the population over 65 years old. In addition to progressive degeneration
of nigrostriatal neurons, the histopathological feature of PD is the accumulation of misfolded
α-synuclein protein in abnormal cytoplasmatic inclusions, known as Lewy Bodies (LBs). Recently,
genome-wide association studies (GWAS) have indicated a clear association of variants within several
lysosomal genes with risk for PD. Newly evolving data have been shedding light on the relationship
between lysosomal dysfunction and alpha-synuclein aggregation. Defects in lysosomal enzymes
could lead to the insufficient clearance of neurotoxic protein materials, possibly leading to
selective degeneration of dopaminergic neurons. Specific modulation of lysosomal pathways and
their components could be considered a novel opportunity for therapeutic intervention for PD.

Aim:

The purpose of this review is to illustrate lysosomal biology and describe the role of lysosomal
dysfunction in PD pathogenesis. Finally, the most promising novel therapeutic approaches designed
to modulate lysosomal activity, as a potential disease-modifying treatment for PD will be
highlighted.
Analisis Ergonomika Lingkungan Fisik Ruang Produksi Tahu terhadap Tingkat Keamanan dan Kenyamanan Pekerja di Kelurahan Abian Tubuh Kota Mataram
Authors:   Universitas Muhammadiyah Mataram, Muanah Muanah , Huda Ahmad Akromul ,   Universitas Muhammadiyah Mataram, Suwati Suwati ,   Universitas Muhammadiyah Mataram
Published: August 2021

Proses pembuatan tahu terdiri dari beberapa rangkaian kerja sehingga perlu pemetaan yang baik dan benar dengan beberapa pertimbangan lingkungan fisik yang aman dan nyaman sesuai ketentuan ilmu ergonomika. Lingkungan fisik yang tidak nyaman atau dengan kata lain berada di bawah atau di atas Nilai Ambang Batas (NAB) dapat menjadi beban tambahan selama bekerja. Tujuan dilakukan penelitian ini adalah untuk mengkaji kondisi ruang produksi pembuatan tahu berdasarkan aspek ergonomika terhadap tingkat keamanan dan kenyamanan pekerja. Metode penelitian menggunakan metode deskriptif dengan pengukuran langsung di lapangan. Hasil penelitian menunjukkan bahwa tingkat pencahayaan berada di bawah NAB karena cahaya pada ruang produksi hanya memanfaatkan cahaya matahari yang menembus dinding dan sirkulasi ruang produksi tanpa ada bantuan penyinaran lampu, sedangkan suhu berada di atas NAB, hal ini terjadi karena panas tidak hanya bersumber dari tungku perebusan saja melainkan bahan pembuatan tahu diproses tanpa menunggu dingin terlebih dahulu. Hasil kajian lainnya pada tingkat kebisingan dan getaran mekanis ditemukan bahwa tidak semua berada di atas NAB melainkan di delapan titik terakhir pada tingkat kebsingan dan 5 stasiun terakhir sudah berada pada NAB. Sehingga dapat disimpulkan bahwa ruang produksi pembuatan tahu perlu penataan kembali untuk kemanan dan kenyamanan pekerja.
Effectiveness of an Internet-Based Machine-Guided Stress Management Program Based on Cognitive Behavioral Therapy for Improving Depression Among Workers: Protocol for a Randomized Controlled Trial
Authors: Kawakami Norito , Imamura Kotaro , Watanabe Kazuhiro , Sekiya Yuki , Sasaki Natsu , Sato Nana ,   SMART-CBT Project Team
Published: August 2021

Background

The effect of an unguided internet-based cognitive behavioral therapy (iCBT) stress management program on depression may be enhanced by applying artificial intelligence (AI) technologies to guide participants adopting the program.

Objective

The aim of this study is to describe a research protocol to investigate the effect of a newly developed iCBT stress management program adopting AI technologies on improving depression among healthy workers during the COVID-19 pandemic.

Methods

This study is a two-arm, parallel, randomized controlled trial. Participants (N=1400) will be recruited, and those who meet the inclusion criteria will be randomly allocated to the intervention or control (treatment as usual) group. A 6-week, six-module, internet-based stress management program, SMART-CBT, has been developed that includes machine-guided exercises to help participants acquire CBT skills, and it applies machine learning and deep learning technologies. The intervention group will participate in the program for 10 weeks. The primary outcome, depression, will be measured using the Beck Depression Inventory II at baseline and 3- and 6-month follow-ups. A mixed model repeated measures analysis will be used to test the intervention effect (group × time interactions) in the total sample (universal prevention) on an intention-to-treat basis.

Results

The study was at the stage of recruitment of participants at the time of submission. The data analysis related to the primary outcome will start in January 2022, and the results might be published in 2022 or 2023.

Conclusions

This is the first study to investigate the effectiveness of a fully automated machine-guided iCBT program for improving subthreshold depression among workers using a randomized controlled trial design. The study will explore the potential of a machine-guided stress management program that can be disseminated online to a large number of workers with minimal cost in the post–COVID-19 era.

Trial Registration

UMIN Clinical Trials Registry（UMIN-CTR) UMIN000043897; https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000050125

International Registered Report Identifier (IRRID)

PRR1-10.2196/30305
Dimmable High Power LED Driver Using Fuzzy Logic Controller
Authors: Rochman Rizky Fatur , Prasetyono Eka , Eviningsih Rachma Prilian
Published: August 2021

The use of lighting loads is one of the crucial matters which increases every year. The increasing use then leads to the development of brighter and longer-lasting sources. In addition, the conventional use of lighting loads today, which only emit light at its maximum intensity, does not allow the consumers to adjust the brightness level as needed. Consequently, this condition may cause energy wastage. The LED lighting system is gaining popularity as it is widely used in a wide range of applications. The advantages of LEDs, such as its compact size and varied lamp colors, replace conventional lighting sources. The linear setting of the driver topology using the flyback converter was aimed to control the LEDs with a constant current in order to adjust the variation of the LED light intensity. The closed-loop driver circuit with flyback converter topology was designed as an LED driver with a given load specification from the LED string. A dimmable feature was included for adjusting the intensity of the light produced by the LEDs. Eventually, the fuzzy logic controller (FLC) method was applied to the integrated change setting to obtain a dynamic response.
Comentarios a la iniciativa que reforma y adiciona diversas disposiciones de la Ley Reglamentaria del Servicio Ferroviario
Authors: Paredes Camacho Jaime De Jesús
Published: August 2021

El Sistema Ferroviario mexicano fue concesionado hace 25 años; la iniciativa Monreal, propone cambios para ofrecer mayor utilidad al Servicio Público Ferroviario, dando mayores facultades a la Agencia Reguladora, para crear una nueva metodología tarifaria y fomentar condiciones no discriminatorias; nuevas herramientas de análisis a rutas interlineales, crear un sistema uniforme de cuentas (SUC) y reportes de los concesionarios para la transparencia; medidas para lograr la competencia efectiva permitiendo a los usuarios solicitar derechos de paso a la Agencia, crear nuevos y que los concesionarios reporten su uso; procedimiento para llegar a acuerdos de interconexión; asimismo la Agencia podrá investigar de oficio incumplimientos al Servicio Público, a la cual le permite también sansionar; Finalmente propone disminur de 50 a 25 años el término de la concesión. El presente trabajo ofrece comentarios a la iniciativa, como elementos que suman para reforzala.
Gamero Casado, Eduardo (dir.), La potestad administrativa. Concepto y alcance práctico de un criterio clave para la aplicación del Derecho administrativo. Valencia, Tirant lo blanc, 2021, 917 pp.
Authors: Gómez Rodríguez Eugenio Alejandro
Published: August 2021

En este libro se  analiza La potestad administrativa, la cual ha sido protagonista en diversas obras de Derecho Administrativo con carácter general, pero nunca se le había dedicado íntegramente una monografía en la manera en que lo hacen aquí estos autores .La monografía se estructura en tres partes. La primera es la Teoría general de la potestad administrativa. La segunda se refiere al ejercicio de potestades administrativas por poderes públicos distintos de la Administración. La última destinada al Análisis sectorial de las potestades administrativas. En total conforman estas tres partes quince capítulos, que se distribuyen en siete, dos y seis, respectivamente; todo ello precedido por una magnífica introducción a cargo del director de la obra.
Consideraciones sobre la sentencia chilena rol 25571-210 a la luz de la convención de viena sobre compraventa internacional de mercaderías
Authors: Inostroza Adasme Sonia
Published: August 2021

Nuestro contrato de compraventa tiene una data de más de dos mil años y, a pesar de que, el modelo que establecen los códigos civiles latinoamericanos contiene modificaciones, en lo sustancial es muy parecido a la creación romana atribuida a Servio Sulpicio Ruffo. La globalización empujó al establecimiento de un estatuto jurídico moderno que estuviera a la altura de las nuevas exigencias mercantiles y fue así como se instauró la Convención de Viena de las Naciones Unidas sobre los Contratos de Compraventa Internacional de Mercaderías. Es a propósito de este nuevo contrato que analizaremos una sentencia chilena en donde advertiremos el avance que han tenido nuestros tribunales en la aplicación de la materia aludida, cuya finalidad es rejuvenecer el esquema de la compraventa
El rol de la administración pública frente a la doble condición del agua: derecho humano y servicio público
Authors: Covilla Martínez Juan Carlos
Published: August 2021

El agua tiene una doble condición: la de derecho humano y de servicio público. Por un lado, como derecho humano, las personas tienen un nivel máximo de protección por parte del juez y la administración pública. Por el otro, como servicio público, en Colombia se ha permitido la liberalización en su prestación, sin lograr aún niveles completos de cobertura. A partir de la pandemia causada por el COVID-19 se dejaron en evidencia los problemas de esta falta de cobertura y se adoptaron medidas excepcionales para mitigar la transmisión del virus. Este artículo plantea la necesidad de adoptar mayores medidas de regulatorias y de intervención directa que lleven a la administración pública a la materialización de este derecho fundamental.
Las tecnologías de la información y comunicación en la justicia administrativa: de la emergencia a su plena incorporación
Authors: Moranchel Pocaterra Mariana
Published: August 2021

En este trabajo pueden encontrarse diversas consideraciones en torno al papel que juegan las Tecnologías de la Información y la Comunicación (TIC) en el ámbito jurisdiccional, particularmente por lo que hace a la justicia administrativa. En ese sentido, se hace una aproximación desde los derechos humanos, a partir de su carácter fundante y unificador del orden jurídico y de las estructuras estatales. El fin que se persigue es poner de relieve el rol transformador de las TIC en el devenir jurisdiccional.
Cómo construir un instrumento para evaluar la lectura crítica de investigación de informes médicos
Authors: Cobos-Aguilar Héctor
Published: August 2021

Introducción: La investigación y la lectura crítica de informes médicos publicados (LCIM), cuando se ejercita, es el fundamento de una actividad clínica depurada. Las publicaciones médicas son exponenciales y una LCIM mejora la selección de artículos con metodología robusta. A pesar de su importancia, los currículos universitarios no enfatizan su aprendizaje. Para medir el grado de LCIM los reportes que utilizan instrumentos adolecen, en su mayoría, de validez y consistencia, lo que dificulta la toma de decisiones educativas en esta área.

Objetivo: Compartir el proceso de construcción de un instrumento de evaluación de LCIM inmerso en una educación participativa.

Métodos: Se presentan los pasos para construir un instrumento para evaluar la LCIM. Se define la lectura crítica como la confrontación del lector con el texto que comprende la interpretación (lo implícito del texto, el reconocimiento de los componentes metodológicos), el juicio (ponderación de los componentes del artículo consultado) y las propuestas (idear componentes que superen a los presentados por el autor) desde la experiencia del lector y en su contexto. Se enuncian los diferentes diseños y apartados que se considera debe contener un instrumento de esta naturaleza. Se propone cómo elaborar un resumen de un artículo, así como los tallos de los que se derivan los reactivos que exploran los tres indicadores citados antes, la técnica Delphi y sugerencias para determinar la consistencia.

Resultados: Se elaboró un resumen de casos y controles, como ejemplo, así como un listado de los tres indicadores, una tabla que los identifica y la secuencia de pasos indispensables en un reporte como este.

Conclusiones: Los instrumentos para medir la LCIM deben seguir un proceso riguroso en su elaboración, lo que permitirá tomar mejores decisiones educativas.
An Analysis of Block Chain Applications In Bitcoin And Smart Grid Technologies
Authors: Vungarala Srujana
Published: August 2021

Blockchain is the nascent technology which has the capability of incorruptible future in making. The blockchain mechanism is regarded for its security. In recent years, many have adopted for Blockchain. This paper tries to analyze some of the game changing technologies using blockchain mechanism. The paper has been framed by using secondary research and the authors’ opinion is also voiced.Blockchain-based application are springing up, covering numerous fields including financial services, Internet of Things (IoT), and Energy distribution systems Smart Grids uses blockchain to control the flow of energy. Blockchain, the foundation of Bitcoin, has received extensive attentions recently. Blockchain serves as an immutable ledger which allows transactions take place in a decentralized manner. Blockchain-Based Smart Grids presents emerging applications of blockchain in electrical system. As, Rapid growth of renewable energy resources in power systems we require a system through which we can monitor the consumption and supply of the electricity. This is sustainable and eco-friendly alternative. This paper is tailored to analyze the blockchain applications in Bitcoin and Smart Grid.
The Study of Digital Adoption and Usage Trends in Kolkata Area
Authors: Shit Sourav
Published: August 2021

This study is based on a research which was done in order to know the awareness and usage of the people toward internet. Mainly this study was focused on the urban people who are lived in the place like Kolkata and much more educated then the rural people. Under this I tried to find out that out of the total sample how many are aware about the internet, how many use internet regularly, how many occasionally (Before 1month), internet owner and non-users. For this study I follow certain process of market research. I had the sample of 65 respondents. For that we conducted this study and collected data from the urban households about their perception and usage of internet it is concern that it aims towards to get direct response form the respondents and to disseminate awareness among the people aware internet. Except this it also has various aims like preference towards internet, purchasing capacity of respondents, fulfill the respondents expectation etc. There are some important factors to carry the research in a careful manner. The key factors are  Active Internet User  Claim Internet User  Internet Owner  Non-User of Internet  Perception and Preference of People Towards Internet
Interés generativo en cuidadores de pacientes crónicos, adultos mayores y jóvenes universitarios
Authors: Reyes Jarquín Karina , González-Celis Rangel Ana Luisa , Bautista-Díaz María Leticia , Díaz Barriga Centli Guillén , Cruz Peralta Ma. de Jesús , Mendoza Madrigal Violeta Alejandra , Raya Ayala Laura Esmeralda , Casado Álvarez María Fernanda
Published: August 2021

La generatividad es el interés del ser humano por guiar, compartir conocimientos, apoyar futuras generaciones y dejar un legado que le sobreviva. Desde la teoría de Erikson esta capacidad se presentaba en la madurez siendo la paternidad la principal actividad generativa. No obstante, investigaciones posteriores indicaron que el interés generativo podría preservarse a través del tiempo y manifestarse también en la vejez, además de poner en duda si la actividad del cuidado indicaba alto interés generativo o presencia de estrés elevado. De tal forma, el objetivo de la presente investigación fue evaluar el interés generativo en cuidadores de pacientes crónicos (CPC), adultos mayores (AM) y jóvenes universitarios (JU), así como determinar las diferencias en el interés generativo y sus dimensiones entre dichos grupos. Los resultados indican diferencias estadísticamente significativas en el interés generativo entre los tres grupos poblacionales, los AM mostraron puntuaciones más altas en el puntaje global (F= 16.12, p = .0001) y poniendo de manifiesto que los CPC mostraron el interés generativo más bajo. En este sentido, aunque los AM y CPC son proveedores de cuidados, la generatividad parece desarrollarse de manera diferencial en ambos grupos debido a los motivos para desempeñar dicha función.
Cambios en el compromiso de universitarios con pareja y uso de redes sociales durante el covid-19
Authors: Escobar-Mota Giovanna , García-Ortega María José , González-Güémez Alessandra , Martín-de la Torre Juliana , Padilla-de Villasante María Fernanda , Rumbos-Quintana Carla Federica , García-Rodríguez Georgina
Published: August 2021

Cada vez hay más estudios que arrojan luz al entendimiento del papel del amor y sus principales componentes como el compromiso (González & García, 2009). Sin embargo, el aislamiento involuntario por COVID-19, incrementó el intercambio en línea con fines románticos a través de aplicaciones y redes sociales (Sierra, 2020). El presente estudio, buscó explorar cambios en las variables de compromiso, satisfacción, inversión y alternativas antes de la pandemia y la actualidad, así como su relación con el uso de redes sociales. Se trabajó con 391 participantes de nacionalidad mexicana, 56% de mujeres de 18 a 48 años, estudiantes de licenciatura o posgrado, con al menos un año de duración en una relación actual. Se compararon dos momentos: antes de la pandemia y en la actualidad, de compromiso, satisfacción, alternativas e inversión, con una prueba T para muestras relacionadas y un análisis de correlaciones bivariadas para conocer la fuerza de asociación entre las mismas, añadiendo la variable de redes sociales. Los resultados muestran un aumento en la percepción de alternativas a la pareja actual, y una disminución en el compromiso y la satisfacción, siendo la inversión la única variable que permaneció estable. Así mismo, el incremento en las alternativas presentó una correlación positiva ante el uso de redes sociales, e inversa con el compromiso, la satisfacción y la inversión. El presente estudio muestra la importancia de la desconexión física y la conexión virtual, y su efecto en las relaciones de pareja, como consecuencia de la modernidad en una economía frágil y cambiante.
ARTE POP E BIZANTINA NA ICONOGRAFIA CARISMÁTICA
Authors: Bonfim Evandro de Sousa
Published: August 2021

O objetivo deste artigo é buscar entender o lugar das referências iconográficas da comunidade carismática católica Canção Nova na proposta de experiência cristã com base na ação do Espírito Santo mantida pelo coletivo. As imagens ilustrando a iconografia Canção Nova foram fotografadas pessoalmente nas diversas dependências da comunidade (lojas, salões dos grupos de oração, complexo da Chácara Santa Cruz, estúdios, capelas) visitadas ao longo da pesquisa de campo e no material gráfico dos produtos em comunicação do grupo. Dois registros artísticos servem de referência para a composição do discurso visual deles: o Bizantino e a Pop Arte. A hipótese a ser trabalhada é de que tais estilos são condizentes com a proposta de Cristianismo do coletivo carismático, baseada nos temas da inovação, em relação a outras formas de praticar o catolicismo, e da transmissão de fluxos espirituais, com destaque para o preenchimento pelo Espírito Santo.
ENTREVISTA COM CHARLES HIRSCHKIND – 19/12/2019
Authors: Reinhardt Bruno , Dullo Eduardo , Antunes Henrique Fernandes
Published: August 2021

-
Efetividade do metronidazol tópico e/ou sistêmico no controle do mau odor de tumores malignos fétidos: revisão sistemática
Authors: Caldeira Brant Juliana Massote , Teodora da Silva Laryssa Hillary
Published: August 2021

Introduction: Fetid tumors are a devastating complication of cancer and cause much discomfort and patient isolation. They usually develop themselves in the last six months of life and they are very difficult to be successfully treated. The aim of this systematic review was to analyze the evidence on the effectiveness of topical and/or systemic metronidazole for the treatment of bad odor in malignant tumor wounds. Results: Sixty-two articles were initially found, and of these, only 4 articles met the inclusion criteria. Two of them were clinical trials, being 1 double-blind, randomized and 1 non-controlled phase III studies. One study was retrospective with a 10-years data collection period and 1 was a cohort prospective study. Of these, 3 analyzed the efficacy of treating malignant tumors with a bad odor using topical metronidazole and only 1 compared the use of topical and systemic metronidazole. Discussion: A factor that contributes to the bad odor not being properly controlled is the lack of standardized protocols. Over the years, studies have tried to find affordable and effective interventions to reduce serious recurrences of bad odor in necrotic wounds. Conclusion: Both topical and systemic routes have been shown to be effective in controlling bad odor. The results of this systematic review highlight the lack of research in this area with little evidence to guide clinical practice in the treatment of these injuries. Further studies are needed to establish more effective protocols to control this distressing condition, experienced by some cancer patients.
Análise da eficácia de dentifrícios clareadores e seus efeitos na superfície dental: um estudo in vitro
Authors: Toschi Eduardo Monteiro , Münchow Eliseu Aldrighi , Mercado Luísa Weber , Melara Rafael , Henz Sandra Liana
Published: August 2021

Tooth whitening can be performed at the dental office, at-home or upon the use of OTC (Over-the-Counter) products. Among the latter, there are whitening toothpastes that promise to bleach and to prevent tooth staining. Objectives: (1) to investigate the bleaching and abrasive potential of different whitening dentifrices to enamel; and (2) to evaluate the effect of Oral-B 3D White Perfection® (Oral-B) toothpaste in preventing staining. Materials and Methods: Bovine enamel samples were stained and brushed for 14 days with water (negative control) or with different products: Colgate Total 12® (control), Oral-B, Sensodyne Branqueador Extra Fresh® (Sensodyne), and Colgate Luminous White Advanced® (Colgate). Oral-B was also tested before and after staining. The samples were tested by their color (spectrophotometer) and surface roughness (profilometer). Color change (ΔDE00) was calculated using the CIEDE2000 color system. The data were analyzed using Kruskal-Wallis, SNK, and Mann-Whitney tests (ɑ=5%). Results: The negative control showed the lowest ΔE00 (p
A influência do tamanho de partícula na reação de presa de cimentos de silicate de cálcio produzidos por sol-gel
Authors: De Cesare Fabio , De Souza Balbinot Gabriela , Castelo Branco Leitune Vicente , Collares Fabrício Mezzomo
Published: August 2021

Introduction: This study aims to analyze the influence of particles size of sol-gel derived calcium silicate particles in the setting reaction of bioactive endodontic cements. Materials and Methods: Sol-gel derived calcium silicate particles were synthesized and sieved to separate the particles in different sizes: CS400, CS200, and CS100. A commercial MTA (Control) was used as control. The particle size and the specific surface area were assessed by laser diffraction and nitrogen adsorption. The cements were prepared with water as the liquid for the reaction. The setting time was conducted according to ISO 6876, and the setting kinetics was analyzed by Fourier transformed infrared spectroscopy (FTIR) at different time points between 120s to 72h. Results: The particle size varied from 9.45µm (CS400 ) to 31.01 (Control). The higher specific surface area valuer reached 15.14g/cm2 in the CS400. The smallest particle sizes, the higher specific surface area, and the lowest setting time were found for CS400 (p < 0.05). Control presented the highest setting time (p < 0.05). The FTIR analyses showed the differences in materials structure over time, with faster hydration and crystallization for CS400. The setting kinetics was slower for Control even when compared to a sol-gel derived group with similar particle size. Conclusion: The route of synthesis and the particle size influences the setting reaction of calcium silicate-based cements. The reduction of particle size for sol-gel derived calcium silicates lead to the acceleration of the setting reaction of the produced bioactive endodontic cement.
A importância da Odontologia na assistência a indivíduos com defeitos congênitos
Authors: Santa Maria Fernanda Diffini , De Oliveira Bibiana Mello , Schuler-Faccini Lavinia
Published: August 2021

Introduction: Birth defects are structural or functional changes that occur during intrauterine life. The dentist must recognize the craniofacial defects, complement the phenotypic characterization and manage them within a multidisciplinary team. The present review aims to assist the dentist to diagnose these findings and present syndromic conditions typically associated with craniofacial malformations

Literature Review: Craniofacial manifestations of birth defects are conditions that must be recognized by dentists, as they are frequently present in their daily practices, and this professional may be the first to identify such findings. The main syndromic clinical pictures typically associated with micrognathia, oral clefts and skeletal dysplasias with craniofacial manifestation are presented, pointing out their clinical and genetic features. Discussion: The dentist must perform a detailed anamnesis including family history, as well as should recognize both clinical and radiographically the dysmorphisms, observing the patient systemically. Conclusion: Dentistry professionals should receive theoretical-practical training for the diagnosis, treatment and surveillance of individuals with congenital defects, either in individual assessment or as part of a multiprofessional team.
Estudantes de Pedagogia em expedição ao ateliê do artista contemporâneo: encontramos o leão na selva
Authors: Lombardi Lucia Maria Salgado dos Santos
Published: August 2021

O artigo reflete sobre expedições para a galeria/ateliê do artista Ernesto Ferro em Sorocaba, SP, realizadas desde 2013 como parte da formação cultural e artística de pedagogas/os da Universidade Federal de São Carlos. A ação questiona: o que profissionais da Educação podem aprender em expedição ao espaço de trabalho do artista contemporâneo? Verificou-se que são favorecidos os exercícios de apreciação, escuta, observação e imaginação. São ampliadas as possibilidades de exploração de materialidades e de produções atuais que inspiram ações a serem feitas com crianças. É propiciada uma transformação das concepções de arte de futuros/as professores/as.
A arte e a cultura afro-brasileira como descentramento sensorial na Pedagogia
Authors: Carvalho Francione Oliveira
Published: August 2021

O artigo discute como a disciplina Arte e Cultura Afro-Brasileira, oferecida no curso de Pedagogia da UFJF, pode desencadear processos significativos que ajudem as/os estudantes a construir novos conhecimentos sobre a arte e o seu ensino. Para isso divide o texto em quatro eixos: 1. A cidade como disparadora de memórias, saberes e experiências; 2. Explorando novos Territórios Educativos; 3. Experiências estéticas-pedagógicas; 4. Processos compartilhados de criação. Aponta que partir de diálogos interdisciplinares e da cultura afro-brasileira pode-se ampliar os atravessamentos sensoriais e perceptivos à que as/os estudantes da Pedagogia são expostas, provocando aquilo que Le Breton (2016) chama de “descentramento sensorial”. Uma maneira de desapegar-se das familiaridades perceptivas para recapturar outras maneiras de “sentir a multidão dos mundos que se escoram no mundo”.
A aventura do “espalha-brasa”: arte na Pedagogia na Universidade Federal do Ceará
Authors: Goldberg Luciane Germano
Published: August 2021

Aborda práticas pedagógicas de arte e educação no curso de Pedagogia da Universidade Federal do Ceará. Serve-se da metáfora do “espalha-brasa”, como referência ao brinquedo de parque diversões que tem cadeiras suspensas que giram no seu próprio eixo em alta velocidade, propondo pensar a arte na Pedagogia como uma experiência estética transformadora, mobilizadora e produtora de novas visões de mundo, sentidos e percepções. Partilha metodologias processuais, vivenciais, ativas e participativas, buscando promover liberdade, autonomia e horizontalidade das relações a partir de processo (auto)biográfico.
Brincando com música em um curso de Pedagogia
Authors: Traverzim Monique
Published: August 2021

Este artigo apresenta um relato de experiência a respeito de um processo de musicalização desenvolvido no curso de Licenciatura em Pedagogia do Centro Universitário Campo Limpo Paulista. Trata-se de uma proposta de educação musical baseada no conceito de experiência de Jorge Larrosa Bondia, em que as estudantes têm a oportunidade de experienciar brincadeiras da cultura tradicional da infância e criar brincadeiras originais. Observou-se que, por meio do brincar, elas puderam reconhecer o potencial musical e criativo que carregam em si, ter contato com conteúdos musicais e refletir acerca dos modos de se trabalhar com música na Educação Infantil e Anos Iniciais do Ensino Fundamental. Espera-se que este relato, junto do repertório de brincadeiras, do referencial bibliográfico e fonográfico que ele traz, possa incentivar as pedagogas em formação e atuantes a desenvolverem trabalhos com música nas escolas de Educação Básica.
Left ventricular summit -- concept, anatomical description and clinical significance
Authors: Kuniewicz Marcin , Baszko Artur , Holda Mateusz , Ali Dyjhana , Karkowski Grzegorz , Walocha Jerzy
Published: August 2021

The left ventricular summit (LVS) is a triangular area located at the
most superior portion of the left epicardial ventricular region,
surrounded by the two branches of the left coronary artery: the left
anterior interventricular artery and the left circumflex artery. The
triangle is bounded by the apex, septal and mitral margins and base.
This review aims to provide a systematic and comprehensive anatomical
description and proper terminology in the LVS region that may facilitate
exchanging information among anatomists and electrophysiologists,
increasing knowledge of this cardiac region. We postulate that the most
dominant septal perforator (not the first septal perforator) should
characterize the LVS definition. Abundant epicardial adipose tissue
overlying the LVS myocardium may affect arrhythmogenic processes and
electrophysiological procedures within the LVS region. The LVS is
divided into two clinically significant regions: accessible and
inaccessible areas. Rich arterial and venous coronary vasculature and a
relatively dense network of cardiac autonomic nerve fibers are present
within the LVS boundaries. Although the approach to the LVS may be
challenging, it can be executed indirectly using the surrounding
structures. Delivery of the proper radiofrequency energy to the
arrhythmia source, avoiding coronary artery damage at the same time, may
be a challenge. Therefore, coronary angiography or cardiac computed
tomography imaging is strongly recommended before any procedure within
the LVS region. Further research on LVS morphology and physiology should
increase the safety and effectiveness of invasive electrophysiological
procedures performed within this region of the human heart.

Published in Diagnostics:

https://doi.org/10.3390/diagnostics11081423