bluuebunny/crossref_metadata_2025 huggingface dataset:
New Method of Papillectomy May Decrease Recurrence: Anchoring Method versus Conventional Method
Authors: Lee Jonghyun , Park Yong Bo , Han Sung Yong , Joo Dong Chan , Hong Seung Min , Yi Kiyoun , Kim Dong Uk
Published: May 2024

Background/Objectives: Endoscopic papillectomy (EP) is the preferred treatment for ampullary tumors because it has fewer side effects than surgical removal. This study retrospectively compared a new anchoring EP method (A-EP) with the conventional (C-EP) approach. Methods: Ninety-nine patients who underwent EP at a single medical institution between 2009 and 2021 were retrospectively reviewed. In all patients, the indications for EP were pathological adenoma with <10 mm of biliary invasion and a tumor diameter <30 mm on endoscopic ultrasonography. The exclusion criteria were antiplatelet/anticoagulant use, previous upper GI surgery, or prior biliary/pancreatic endoscopic therapy. One expert endoscopist performed the two types of EPs, A-EP and C-EP. Results: Sixty-two patients underwent A-EP, and 37 underwent C-EP. There were no significant differences in baseline characteristics, such as sex, age, tumor size, and ductal invasion on endoscopic ultrasound. The A-EP group had higher en bloc resection rates (95.2% vs. 78.4%, p = 0.010). Although the difference was not statistically significant, it tended towards fewer incidences of pancreatitis (p = 0.081) and duct stricture (p = 0.081). The recurrence rate was lower in the A-EP group (8.1% vs. 37.8%, p = 0.000). There were no significant differences between the two groups regarding the follow-up period (A-EP vs. C-EP, 725 vs. 1045 days, p = 0.109) or the days of recurrence (A-EP vs. C-EP, 341 vs. 562 days, p = 0.551). Conclusions: A-EP showed better outcomes than C-EP in terms of en bloc resection and recurrence rates, providing evidence for the efficacy of this novel EP method.
Remote Delivery of Partial Meal Replacement for Weight Loss in People Awaiting Arthroplasty
Authors: Chimoriya Ritesh , Naylor Justine , Mitlehner Kimberly , Adie Sam , Harris Ian , Bell-Higgs Anna , Brosnahan Naomi , Piya Milan K.
Published: May 2024

Background: Obesity is linked to higher rates of complications; lower absolute recovery of mobility, pain, and function; and increased costs of care following total knee or hip arthroplasty (TKA, THA). The aim of this prospective cohort study was to evaluate the effectiveness of a 12-week partial meal replacement (PMR) weight loss program for people awaiting TKA or THA and living with obesity (body mass index (BMI) ≥ 30 kg/m2). Methods: The intervention was delivered remotely and included a 12-week PMR plan of 1200 calories/day, incorporating two meal replacement shakes/soups and a third suitable simple meal option. The intervention support was provided through online group education sessions, one-to-one teleconsultation with a dietitian, and access to a structured PMR App with functions for goal setting and providing educational content on diet, physical activity, and behaviour changes. Results: Of the 182 patients approached, 29 provided consent to participate, 26 participants commenced the program, and 22 participants completed the 12-week PMR plan. Completers exhibited statistically significant weight loss from baseline to 12 weeks, with a paired difference of 6.3 kg (95% CI: 4.8, 7.7; p < 0.001), with 15 out of 22 (68.2%) participants achieving at least 5% weight loss. Statistically significant reductions in HbA1c and low density lipoprotein (LDL) were observed at 12 weeks compared to baseline. Moreover, a significant increase in the proportion of participants in the action and maintenance phases of the readiness to change diet, physical activity, and weight were observed at 12 weeks. The majority of program completers (18 out of 22) expressed willingness to pay for the service if offered on a long-term basis following the arthroplasty. Conclusions: This study’s findings demonstrated that significant weight loss is achievable for people living with obesity awaiting arthroplasty following a 12-week PMR weight loss program. The remote delivery of the intervention was feasible and well accepted by people awaiting TKA or THA.
The Trends and Outcomes of Initial Palliative Chemotherapy in Patients with Pancreatic Cancer in Korea Based on National Health Insurance Service Data
Authors: Jang Dong , Kim Young , Lee Jang , Kim Hakjun , Lee Yoon , Chun Jung , Lee Jong-Chan , Woo Sang , Hwang Jin-Hyeok
Published: May 2024

Background/Objectives: The survival rate of patients with pancreatic cancer (PC) has improved gradually since the introduction of FOLFIRINOX (FFX) and gemcitabine + albumin-bound paclitaxel (GnP) regimens. However, the trends and outcomes of initial palliative chemotherapy before and after the advent of these regimens and their contribution to survival rates are not well understood. This study aimed to investigate this in patients with PC in Korea using claims data from the National Health Insurance Service (NHIS). Methods: Patients diagnosed with PC who underwent initial palliative chemotherapy between 2007 and 2019 were identified from the NHIS database. Patient demographics, comorbidities, chemotherapy regimens, and survival rates were analyzed using follow-up data up to 2020. Results: In total, 14,760 patients (mean age, 63.78 ± 10.18 years; men, 59.19%) were enrolled. As initial palliative chemotherapy, 3823 patients (25.90%) received gemcitabine alone; 2779 (18.83%) received gemcitabine + erlotinib; 1948 (13.20%) received FFX; and 1767 (11.97%) received GnP. The median survival values were 15.00 months for FFX; 11.04 months for GnP; 8.40 months for gemcitabine alone; and 8.51 months for gemcitabine + erlotinib. The adjusted hazard ratio (aHR) for GnP vs. FFX was 1.291 (95% CI, 1.206–1.383) in the multivariate Cox regression analysis of mortality. Radiation therapy (aHR, 0.667; 95% CI, 0.612–0.728) and second-line chemotherapy (aHR, 0.639; 95% CI, 0.597–0.684) were significantly associated with improved survival. Conclusions: Our study found that first-line chemotherapy with FFX was associated with significantly longer survival than the other regimens, although caution is needed in interpreting the results.
Epidemiology and Healthcare Service Utilization among Adults with Chronic Cough
Authors: Chodick Gabriel , Barer Yael , Blay Hagai Tal , Keidar Ido , Rosenfeld Teper Gally , Kopel Hagit , Berkman Neville
Published: May 2024

Background and objective: Chronic cough (CC) is a prevalent yet underexplored medical condition, with limited real-world data regarding its healthcare burden. This study investigates the epidemiology, associated comorbidities, and healthcare service utilization among patients with CC. Methods: In this retrospective cohort study, adult patients with at least 3 physician diagnoses of cough over a period spanning a minimum of 8 weeks and a maximum of 12 months anytime between 2009 and 2018, were defined as patients with CC (PwCC). The reference group were adults without cough matched in a 1:1 ratio for age, sex, and place of residence. Results: The study included 91,757 PwCC, reflecting a prevalence of 5.5%. Of those, 59,296 patients (mean [SD] age, 53.9 [16.8] years; 59.6% females) were first diagnosed with CC during the study period, representing a 10-year incidence rate of 3.26% (95%CI: 3.24–3.29%). Diseases associated with the highest OR for CC included lung cancer (OR = 3.32; 95%CI: 2.90–4.25), whooping cough (OR = 3.04; 95%CI: 2.70–3.60), and respiratory infections (OR = 2.81; 95%CI: 2.74–2.88). Furthermore, PwCC demonstrated increased healthcare service utilization, leading to a higher adjusted annual estimated mean cost (USD 4038 vs. USD 1833, p < 0.001). Conclusions: Chronic cough emerges as a relatively prevalent complaint within community care, exerting a considerable economic burden. This study underscores the need for heightened awareness, comprehensive management strategies, and resource allocation to address the multifaceted challenges associated with chronic cough.
Sentinel Lymph Node Biopsy in Atypical Spitz Tumor: A Systematic Review
Authors: Mazza Marcodomenico , Cavallin Francesco , Galasso Elisa , Del Fiore Paolo , Cappellesso Rocco , Cassalia Fortunato , Tropea Saveria , Russo Irene , Alaibac Mauro , Mocellin Simone
Published: May 2024

Background: Atypical Spitz tumor (AST) is an intermediate category among Spitz melanocytic neoplasms. Sentinel node biopsy (SNB) has been proposed in the clinical management of AST patients, but this approach remains the subject of debate. This systematic review aims to summarize the available evidence on SNB procedures in AST patients. Methods: A comprehensive search was conducted, including MEDLINE/Pubmed, EMBASE, and SCOPUS, through April 2023. Case series, cohort studies, and case–control studies of AST patients were eligible for inclusion. PRISMA guidelines were followed. Results: Twenty-two studies with a total of 756 AST patients were included. The pooled SNB prevalence was 54% (95% CI 32 to 75%), with substantial heterogeneity (I2 90%). The pooled SNB+ prevalence was 35% (95% CI 25 to 46%) with moderate heterogeneity (I2 39%). Lymphadenectomy was performed in 0–100% of SNB+ patients. Overall survival rates ranged from 93% to 100%, and disease-free survival ranged from 87% to 100% in AST patients. Overall and disease-free survival rates were 100% in SNB patients. Pooled survival estimates were not calculated due to the heterogeneous timing of the survival assessment and/or the small size of the subgroups. All studies clearly reported inclusion criteria and measured the condition in a standard way for all participants, but only 50% indicated valid methods for the identification of the condition. Conclusions: The oncologic behavior of AST is related to an almost always favorable outcome. SNB does not seem to be relevant as a staging or prognostic procedure, and its indication remains debatable and controversial.
Maxillofacial Bone Involvement in Fibro-Osseous Lesions: Emphasizing the Significance of Differential Diagnosis
Authors: Gennaro Paolo , Gennari Luigi , Latini Linda , Cavati Guido , Vannucchi Margherita , Giovannetti Filippo , Cascino Flavia
Published: May 2024

The World Health Organization’s (WHO) 2022 update on the classification of odontogenic and maxillofacial bone tumors has revolutionized diagnostic and treatment paradigms by integrating novel molecular insights. Fibro-osseous lesions of the maxillo-facial bones constitute a heterogeneous group encompassing fibrous dysplasia, Psammomatoid Ossifying Fibroma (PSOF), Juvenile Trabecular Ossifying Fibroma (JTOF), and other variants. Despite histological similarities, their distinct clinical manifestations and prognostic implications mandate precise differentiation. The intricacies of diagnosing fibro-osseous lesions pose challenges for pathologists, maxillofacial surgeons, dentists and oral surgeons, underscoring the importance of a systematic approach to ensure optimal patient management. Herein, we present two cases, fibrous dysplasia and Cemento-Ossifying Fibroma, detailing their clinical encounters and management strategies. Both patients provided informed consent for publishing their data and images, adhering to ethical guidelines.
Sex-Specific Analysis of Mid-Term Outcomes of Atherectomy-Assisted Endovascular Treatment in Severe Peripheral Arterial Disease
Authors: Avranas Konstantinos , Pitoulias Apostolos G. , Taneva Gergana T. , Beropoulis Efthymios , Donas Konstantinos P.
Published: May 2024

Background: Endovascular treatment of lower-extremity peripheral disease (PAD) is associated with higher complication rates and suboptimal outcomes in women. Atherectomy has shown favourable outcomes in calcified lesions, minimising the incidence of stent placement caused by recoil or flow-limiting dissection. To date, there are no published mid-term outcomes evaluating the performance of atherectomy differentiated by sex. This study aims to evaluate sex-specific outcomes and prognostic factors affecting the results of atherectomy-assisted endovascular treatment in severe PAD. Methods: A retrospective analysis was conducted at a single centre in Germany, initiated by physicians and not sponsored by industry, on patients presenting with Rutherford categories ranging from III to V and featuring de novo occlusive or stenotic lesions of the superficial femoral (SFA) and/or popliteal arteries. The intervention involved rotational atherectomy-assisted angioplasty utilising the Jetstream (Boston, US®) device. The point of interest of this study was postinterventional clinical improvement as well as mid-term outcomes, including primary patency, over a targeted 2-year follow-up period. Statistical analysis utilised Cox regression (survival analysis) to calculate hazard ratios according to sex category. Comparative survival analysis was performed using the log-rank test and visually represented through Kaplan–Meier curves. Risk factors associated with absence of clinical improvement were examined across both sex groups utilising the chi-square or Fisher exact test, as appropriate. Results: A total of 98 patients (103 limbs) were initially included, with >75% having moderate-to-severe lesion calcification (>50%). A total of 84 patients (97 limbs, 62 male and 35 female) proceeded to a 2-year follow-up (mean 16.4 months for males and 16.1 for females) after a successful index procedure. Age distribution, Rutherford class, diabetes, chronic kidney disease (CKD), target vessel, lesion type, and length were balanced among both groups. Similar primary patency rates, of 89% among female and 91% among male limbs, were observed (p = 0.471). Female patients exhibited a lower rate of clinical improvement based on the Rutherford scale in comparison to males (80.6% vs. 94.5%, p = 0.048). CDK was the only significant prognostic factor across pooled data (odds ratio for CKD: 15.15, p < 0.001). Conclusions: Rotational atherectomy showed comparably high rates of mid-term primary patency, with low rates of bailout stent placement. These findings highlight the beneficial use of atherectomy in female patients who are per se at risk for higher rates of complications during and after endovascular interventions.
Subclinical Atrial Fibrillation: To Anticoagulate or Not?
Authors: Kommu Sharath , Sharma Param P.
Published: May 2024

Atrial fibrillation (AF) carries a stroke risk, often necessitating anticoagulation, especially in patients with risk factors. With the advent of implantable and wearable heart monitors, episodes of short bouts of atrial arrhythmias called atrial high-rate episodes (AHREs) or subclinical AF (SCAF) are commonly identified. The necessity of anticoagulation in patients with SCAF is unclear. However, recent randomized controlled trials, the NOAH-AFNET 6 and ARTESIA, have offered insights into this matter. Furthermore, a study-level meta-analysis combining data from both these trials has provided more detailed information. Reviewing the information thus far, we can conclude that DOACs can result in a notable reduction in the risk of ischemic stroke and can potentially decrease the risk of debilitating stroke, albeit with an increased risk of major bleeding. Thus, informed, shared decision-making is essential, weighing the potential benefits of stroke prevention against the risk of major bleeding when considering anticoagulation in this patient population.
Use of Proton Pump Inhibitors Is Not Associated with Post-Dialysis Fatigue and Time of Recovery after Dialysis in Patients on Maintenance Hemodialysis
Authors: Bossola Maurizio , Mariani Ilaria , Monteburini Tania , Parodi Emanuele , Santarelli Stefano , Sirolli Vittorio , Cenerelli Stefano , Bonomini Mario , Tedesco Silvia , Spoliti Claudia , Di Stasio Enrico
Published: May 2024

Objectives: To define if the use of proton pump inhibitors (PPI) is associated with PDF prevalence and characteristics and with time of recovery after dialysis in patients on maintenance hemodialysis. Methods: Patients were defined as experiencing PDF if they spontaneously offered this complaint when asked the open-ended question: “Do you feel fatigued after dialysis?”. Time of recovery after dialysis (TIRD) was also assessed for each patient. Each patient was invited to rate the intensity, duration and frequency of PDF from 1 to 5. We defined if patients used PPI (no PPI use or PPI use), the type of used PPI, the dose of used PPI, and the duration of the use of PPI (<1 year or ≥1 year). Results: A total of 346 patients were studied: 259 used PPI (55 used omeprazole, 63 esomeprazole, 54 pantoprazole, 87 lansoprazole, and 7 rabeprazole) and 87 did not. Two hundred and thirty-two patients declared PDF and 114 did not. The median [min–max] TIRD was 210 min [0–1440]. The prevalence of PDF in PPI users and PPI non-users was 67% and 68%, respectively (p = 0.878). The median [min–max] TIRD did not differ significantly between PPI users and PPI non-users (180 [0–1440] and 240 [0–1440], respectively; p = 0.871). Median PDF intensity, duration, frequency, and severity did not differ significantly between PPI use and no use. The prevalence of PDF was similar among the different types of PPI use and did not differ with respect to PPI non-users. Duration of PPI exposure was <1 year in 40 patients and ≥1 year in 219 patients. The prevalence of PDF did not differ between the two exposures. The correlation matrix between PPI equivalent dose, PPI treatment duration and PDF frequency, PDF characteristics, and TIRD showed whether there was statistical significance. Conclusions: The use of PPI is not associated with PDF and time of recovery after dialysis in patients on maintenance hemodialysis.
The Value of Ischemic Cardiac Biomarkers to Predict Spontaneous Breathing Trial or Extubation Failure: A Systematic Review
Authors: Groenland Carline N. L. , Blijleven Maud A. , Ramzi Imane , Dubois Eric A. , Heunks Leo , Endeman Henrik , Wils Evert-Jan , Baggen Vivan J. M.
Published: May 2024

Background: It is unclear whether other cardiac biomarkers than NT-proBNP can be useful in the risk stratification of patients weaning from mechanical ventilation. The aim of this study is to summarize the role of ischemic cardiac biomarkers in predicting spontaneous breathing trial (SBT) or extubation failure. Methods: We systematically searched Embase, MEDLINE, Web of Science, and Cochrane Central for studies published before January 2024 that reported the association between ischemic cardiac biomarkers and SBT or extubation failure. Data were extracted using a standardized form and methodological assessment was performed using the QUIPS tool. Results: Seven observational studies investigating four ischemic cardiac biomarkers (Troponin-T, Troponin-I, CK-MB, Myoglobin) were included. One study reported a higher peak Troponin-I in patients with extubation failure compared to extubation success (50 ng/L [IQR, 20–215] versus 30 ng/L [IQR, 10–86], p = 0.01). A second study found that Troponin-I measured before the SBT was higher in patients with SBT failure in comparison to patients with SBT success (100 ± 80 ng/L versus 70 ± 130 ng/L, p = 0.03). A third study reported a higher CK-MB measured at the end of the SBT in patients with weaning failure (SBT or extubation failure) in comparison to weaning success (8.77 ± 20.5 ng/mL versus 1.52 ± 1.42 ng/mL, p = 0.047). Troponin-T and Myoglobin as well as Troponin-I and CK-MB measured at other time points were not found to be related to SBT or extubation failure. However, most studies were underpowered and with high risk of bias. Conclusions: The association with SBT or extubation failure is limited for Troponin-I and CK-MB and appears absent for Troponin-T and Myoglobin, but available studies are hampered by significant methodological drawbacks. To more definitively determine the role of ischemic cardiac biomarkers, future studies should prioritize larger sample sizes, including patients at risk of cardiac disease, using stringent SBTs and structured timing of laboratory measurements before and after SBT.
Mitochondrial Protease Oct1p Regulates Mitochondrial Homeostasis and Influences Pathogenicity through Affecting Hyphal Growth and Biofilm Formation Activities in Candida albicans
Authors: Zhu Xiaoxiao , Jin Feng , Yang Guangyuan , Zhuang Tian , Zhang Cangcang , Zhou Hanjing , Niu Xiaojia , Wang Hongchen , Wu Daqiang
Published: May 2024

Mitochondria, as the core metabolic organelles, play a crucial role in aerobic respiration/biosynthesis in fungi. Numerous studies have demonstrated a close relationship between mitochondria and Candida albicans virulence and drug resistance. Here, we report an octapeptide-aminopeptidase located in the mitochondrial matrix named Oct1p. Its homolog in the model fungus Saccharomyces cerevisiae is one of the key proteins in maintaining mitochondrial respiration and protein stability. In this study, we utilized evolutionary tree analysis, gene knockout experiments, mitochondrial function detection, and other methods to demonstrate the impact of Oct1p on the mitochondrial function of C. albicans. Furthermore, through transcriptome analysis, real-time quantitative PCR, and morphological observation, we discovered that the absence of Oct1p results in functional abnormalities in C. albicans, affecting hyphal growth, cell adhesion, and biofilm formation. Finally, the in vivo results of the infection of Galleria mellonella larvae and vulvovaginal candidiasis in mice indicate that the loss of Oct1p led to the decreased virulence of C. albicans. In conclusion, this study provides a solid theoretical foundation for treating Candida diseases, developing new targeted drugs, and serves as a valuable reference for investigating the connection between mitochondria and virulence in other pathogenic fungi.
Red-Haired People’s Altered Responsiveness to Pain, Analgesics, and Hypnotics: Myth or Fact?—A Narrative Review
Authors: Augustinsson Annelie , Franze Elisabeth , Almqvist Martina , Warrén Stomberg Margareta , Sjöberg Carina , Jildenstål Pether
Published: May 2024

Red hair has been linked to altered sensitivity to pain, analgesics, and hypnotics. This alteration may be impacted by variants in the melanocortin-1 receptor (MC1R) gene, which are mainly found in redheads. The aim of this narrative review was to explore and present the current state of knowledge on red hair and its plausible associations with altered responsiveness to pain, analgesics, and hypnotics. Structured searches in the PubMed, CINAHL Complete, and Scopus electronic databases were conducted. Evidence suggests that women with red hair have an increased sensitivity to pain. Conversely, data also indicate a higher pain tolerance in homozygous carriers of MC1R variant alleles. Varied responses to analgesia have been reported, with both increased analgesic responsiveness in homozygous carriers of MC1R variant alleles and less analgesia in redheads. Data indicate an increased need for hypnotics in redheads. However, failed attempts to find statistical associations between red hair and altered responsiveness to hypnotics are also evident. Even though there seems to be an association between red hair and an altered responsiveness to pain, analgesics, and/or hypnotics, the results of this narrative review are inconclusive. Further research studies with larger populations and MC1R testing are needed.
Shoulder Dystocia: A Comprehensive Literature Review on Diagnosis, Prevention, Complications, Prognosis, and Management
Authors: Tsikouras Panagiotis , Kotanidou Sonia , Nikolettos Konstantinos , Kritsotaki Nektaria , Bothou Anastasia , Andreou Sotiris , Nalmpanti Theopi , Chalkia Kyriaki , Spanakis Vlassios , Peitsidis Panagiotis , Iatrakis George , Nikolettos Nikolaos
Published: May 2024

The term dystocia refers to labor characterized by a slow progression with delayed rates or even pauses in the dilation of the cervix or the descent of the fetus. Dystocia describes the deviation from the limits that define a normal birth and is often used as a synonym for the term pathological birth. Shoulder dystocia, also known as the manual exit of the shoulders during vaginal delivery on cephalic presentation, is defined as the “failure of the shoulders to spontaneously traverse the pelvis after delivery of the fetal head”. This means that obstetric interventions are necessary to deliver the fetus’s body after the head has been delivered, as gentle traction has failed. Abnormal labor (dystocia) is expressed and represented in partograms or by the prolongation of the latent phase or by slowing and pausing in the phases of cervical dilatation and fetal descent. While partograms are helpful in visualizing the progress of labor, regular use of them has not been shown to enhance obstetric outcomes considerably, and no partogram has been shown to be superior to others in comparative trials. Dystocia can, therefore, appear in any phase of the evolution of childbirth, so it is necessary to simultaneously assess all the factors that may contribute to its abnormal evolution, that is, the forces exerted, the weight, the shape, the presentation and position of the fetus, the integrity and morphology of the pelvis, and its relation to the fetus. When this complication occurs, it can result in an increased incidence of maternal morbidity, as well as an increased incidence of neonatal morbidity and mortality. Although several risk factors are associated with shoulder dystocia, it has proven impossible to recognize individual cases of shoulder dystocia in practice before they occur during labor. Various guidelines have been published for the management of shoulder dystocia, with the primary goal of educating the obstetrician and midwife on the importance of a preplanned sequence of maneuvers, thereby reducing maternal and neonatal morbidity and mortality.
Internal and External Validation of Machine Learning Models for Predicting Acute Kidney Injury Following Non-Cardiac Surgery Using Open Datasets
Authors: Lee Sang-Wook , Jang Jaewon , Seo Woo-Young , Lee Donghee , Kim Sung-Hoon
Published: May 2024

This study developed and validated a machine learning model to accurately predict acute kidney injury (AKI) after non-cardiac surgery, aiming to improve patient outcomes by assessing its clinical feasibility and generalizability. We conducted a retrospective cohort study using data from 76,032 adults who underwent non-cardiac surgery at a single tertiary medical center between March 2019 and February 2021, and used data from 5512 patients from the VitalDB open dataset for external model validation. The predictive variables for model training consisted of demographic, preoperative laboratory, and intraoperative data, including calculated statistical values such as the minimum, maximum, and mean intraoperative blood pressure. When predicting postoperative AKI, our gradient boosting machine model incorporating all the variables achieved the best results, with AUROC values of 0.868 and 0.757 for the internal and external validations using the VitalDB dataset, respectively. The model using intraoperative data performed best in internal validation, while the model with preoperative data excelled in external validation. In this study, we developed a predictive model for postoperative AKI in adult patients undergoing non-cardiac surgery using preoperative and intraoperative data, and external validation demonstrated the efficacy of open datasets for generalization in medical artificial modeling research.
Effects of Biodanza® SRT on Motor, Cognitive, and Behavioral Symptoms in Patients with Parkinson’s Disease: A Randomized Controlled Study
Authors: Vitale Carmine , Rosa Roberta , Agosti Valeria , Siciliano Mattia , Barra Giuseppe , Maggi Gianpaolo , Santangelo Gabriella
Published: May 2024

Rolando Toro’s Biodanza (SRT) is a therapeutic strategy that uses movement, music, and emotions to induce integrative living experiences. The present study aims to explore the efficacy of a three-month SRT intervention on motor, cognitive, and behavioral symptoms in patients with Parkinson’s disease (PD). This study employed a randomized between-group design. Twenty-eight non-demented PD patients were enrolled in this study. Out of these, fourteen patients were assigned to the active treatment group using the Biodanza SRT system and fourteen to the untreated control group. The study group attended 2 h SRT classes once a week, completing twelve lessons in twelve weeks. All patients underwent: (i) a neurological examination to measure the severity of motor symptoms, balance, mobility, and risk of falls, and (ii) a neuropsychological battery to assess cognitive status, apathy, depressive symptomatology, and perceived quality of life (QoL), at study entry (T0) and at twelve weeks (T1, end of dance training). At T1, we observed a significant improvement in motor (i.e., severity of motor symptoms and balance) and cognitive parameters (i.e., working memory and delayed verbal memory) in all treated patients compared with the controls. Furthermore, a significant improvement in the social support dimension was found in all treated patients compared to the controls. A trend toward increased apathy was found in untreated patients at T1. The three-month Biodanza intervention significantly ameliorated the motor parameters of PD patients, with a parallel improvement in cognitive and QoL status. Hence, Biodanza intervention can, in the short term, represent a useful personalized medical intervention for the management of Parkinson’s disease.
Metal–Organic-Framework-Derived Nitrogen-Doped Carbon-Matrix-Encapsulating Co0.5Ni0.5 Alloy as a Bifunctional Oxygen Electrocatalyst for Zinc–Air Batteries
Authors: Liu Jinglin , Han Lina , Xiao Shicai , Zhu Anqi , Zhang Yingjie , Zeng Xiaoyuan , Dong Peng
Published: May 2024

The development of low-cost, high-performance oxygen electrocatalysts is of great significance for energy conversion and storage. As a potential substitute for precious metal electrocatalysts, the construction of efficient and cost-effective oxygen electrocatalysts is conducive to promoting the widespread application of zinc–air batteries. Herein, CoxNiyMOF nanoparticles encapsulated within a carbon matrix were synthesized and employed as cathode catalysts in zinc–air batteries. Co0.5Ni0.5MOF exhibits superior oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) performance and durability. The zinc–air battery assembled with Co0.5Ni0.5MOF as the air cathode exhibits a maximum power density of 138.6 mW·cm−2. These improvements are mainly attributed to the optimized metal composition of the cobalt–nickel alloy, which increases the specific surface area of the material and optimizes its pore structure. Significantly, the optimization of the electronic structure and active sites within the material has led to amplified ORR/OER activity and better zinc–air battery performance. This study underscores the immense promise of Co0.5Ni0.5MOF catalysts as feasible substitutes for commercial Pt/C catalysts in zinc–air batteries.
Weld Zone Analysis Based on FCAW Mechanical Characteristics and Heat Transfer Analysis of 316L Stainless Steel for Liquefied Hydrogen Tanks
Authors: Kim Younghyun , Hong Sungbin , Ha Eulyong , Park Gyuhae , Kim Jaewoong
Published: May 2024

The International Maritime Organization (IMO) is currently rolling out more restrictive regulations in order to achieve net-zero GHG emissions by 2050. In response, the shipping industry is planning to pivot to green energy sources such as hydrogen fuel. However, since hydrogen has an extremely low boiling point (−253 °C), materials for storing liquid hydrogen must be highly resistant to low-temperature brittleness and hydrogen embrittlement. A 316L stainless steel is a typical material that meets these requirements, and various welds have been studied. In this study, 3 pass butt welding was performed by applying the FCAW (flux cored arc welding) process to 10 mm thick ASTM-A240M-316L stainless steel, with the size of the fusion zone and HAZ investigated by mechanical testing and heat transfer FE analysis according to process variables, such as heat input, welding speed, and the number of passes. In all cases, the yield and tensile strengths were about 10% and 3% higher than the base metal, respectively. Furthermore, heat transfer FE analysis showed an average error rate of 1.3% for penetration and 10.5% for width and confirmed the size of the HAZ, which experienced temperatures between 500 °C and 800 °C.
Effect of Solid-State Phase Transformation and Transverse Restraint on Residual Stress Distribution in Laser–Arc Hybrid Welding Joint of Q345 Steel
Authors: Feng Ruiyang , Liu Denggao , Zhang Chaohua , Pan Yunlong , Wang Yanjun , Chen Jie , Ye Xiaojun , Lei Min , Li Yulong
Published: May 2024

A Q345 steel butt-welded joint was manufactured using laser–arc hybrid welding (LAHW) technology, and its microstructure, microhardness, and residual stress (RS) distribution were measured. Using ABAQUS software, a sequentially coupled thermo-metallurgical-mechanical finite element method was employed to model the welding RS distribution in the LAHW joint made of Q345 steel. The effects of solid-state phase transformation (SSPT) and transverse restraint on the welding RS distribution were explored. The results show that a large number of martensite phase transformations occurred in the fusion zone and heat-affected zone of the LAHW joint. Furthermore, the SSPT had a significant effect on the magnitude and distribution of RS in the LAHW joint made of Q345 steel, which must be taken into account in numerical simulations. Transverse restraints markedly increased the transverse RS on the upper surface, with a comparatively minor impact on the longitudinal RS distribution. After the transverse restraint was released, both the longitudinal and transverse RS distributions in the LAHW joint reverted to a level akin to that of the welded joint under free conditions.
Research on Resource Recovery and Disposal of Copper-Containing Sludge
Authors: Yu Jinao , Zhou Yongmin
Published: May 2024

Copper-containing sludge is a common by-product of industrial activities, particularly electroplating and metal processing. This type of sludge contains high concentrations of heavy metals such as copper, which can pose a potential threat to the environment. Therefore, its treatment and disposal require special attention. Due to its efficient mass and heat transfer characteristics, the suspended state technology has shown significant potential for application in a number of key processes, including the drying, decomposition, and reduction of copper-containing sludge. This paper presents an in-depth analysis of the current status of the application of the suspended state technology in the treatment of copper-containing sludge. Based on this analysis, a device for the treatment of copper-containing sludge in the suspended state was designed, through which the characteristics of copper-containing sludge in the oxidative decomposition and reduction phases are investigated. The research objects were gas concentration, temperature, contact state, and particle size time. Orthogonal experiments were initially employed to investigate the relationship between the influencing factors and the conversion rate of copper oxides. This was followed by a single-factor influence study, which led to the determination of the optimal process parameters for the decomposition experiments of the Cu-containing sludge in an oxidizing atmosphere. The 100 μm Cu-containing sludge was reacted with 10% O2 gas at a flow rate of 1 m/s for 3 min under the condition of 900 °C. The process parameters were then determined as follows: The research objects were gas concentration, temperature, contact state, and particle size time. Orthogonal experiments were employed to investigate the relationship between the influencing factors and the copper conversion rate. This was followed by a single-factor influence study, which determined the optimal process parameters for the copper-containing sludge reduction experiments. The 200 μm copper-containing sludge was reacted for 5 min at a flow rate of 7% carbon monoxide at a flow rate of 1.5 m/s under the condition of 800 °C.
Enhanced Hydrogen Generation through Low-Temperature Plasma Treatment of Waste Aluminum for Hydrolysis Reaction
Authors: Urbonavicius Marius , Varnagiris Sarunas , Knoks Ainars , Mezulis Ansis , Kleperis Janis , Richter Christiaan , Meirbekova Rauan , Gunnarsson Gudmundur , Milcius Darius
Published: May 2024

This study investigates the low-temperature hydrogen plasma treatment approach for the improvement of hydrogen generation through waste aluminum (Al) reactions with water and electricity generation via proton-exchange membrane fuel cell (PEM FC). Waste Al scraps were subjected to ball milling and treated using two different low-temperature plasma regimes: Diode and magnetron-initiated plasma treatment. Hydrolysis experiments were conducted using powders with different treatments, varying molarities, and reaction temperatures to assess hydrogen generation, reaction kinetics, and activation energy. The results indicate that magnetron-initiated plasma treatment significantly enhances the hydrolysis reaction kinetics compared to untreated powders or those treated with diode-generated plasma. Analysis of chemical bonds revealed that magnetron-initiated hydrogen plasma treatment takes advantage by promoting a dual procedure: Surface cleaning and Al nanocluster deposition on top of Al powders. Moreover, it was modeled that such H2 plasma could penetrate up to 150 Å depth. Meanwhile, electricity generation tests demonstrate that only 0.2 g of treated Al powder can generate approximately 1 V for over 300 s under a constant 2.5 Ω load and 1.5 V for 2700 s with a spinning fan.
A Top-Down Approach to the Fabrication of Flame-Retardant Wood Aerogel with In Situ-Synthesized Borax and Zinc Borate
Authors: Lin Mingzeng , Guo Xiangkun , Xu Yinchao , Zhang Xuejin , Hu Donghao
Published: May 2024

In this study, a top-down approach was employed for the fabrication of flame-retardant wood aerogels. The process involved the removal of lignin and the removal of hemicellulose utilizing NaOH concomitantly with the incorporation of ZnO and urea. Subsequently, an in situ reaction with boric acid was conducted to prepare flame-retardant wood aerogels. The morphology, chemical composition, thermal stability, and flame retardancy of the samples were studied. The results show that the NaOH treatment transformed the wood into a layered structure, and flame-retardant particles were uniformly distributed on the surface of the aerogel. The peak heat release rate (PHRR) and total heat release (THR) of the flame-retardant aerogel were significantly reduced compared with the control samples. Meanwhile, its vertical burning test (UL-94) rating reached the V-0 level, and the Limiting Oxygen Index (LOI) could exceed 90%. The flame-retardant wood aerogel exhibited excellent flame retardancy and self-extinguishing properties.
Influence of Pre- and Post-Contouring Strategies to Downskin Sloped Surfaces in Laser Powder-Bed Fusion (L-PBF) Additive Manufacturing
Authors: Valiyakath Vadakkan Habeeb Nismath , Islam Rabiul , Chou Kevin
Published: May 2024

Among various metal additive manufacturing (AM) technologies, L-PBF is known for fabricating intricate components. However, due to step edges and powder particle attachments, attaining a good surface finish is challenging, especially on downskin surfaces. Contour scanning has potential to improve surface quality because such scanning may dominate the surface formation of sloped features. This study evaluates the effects of pre- and post-contouring strategies on the sloped downskin surfaces fabricated using a commercial L-PBF system with Ti6Al4V powder. L-PBF parts printed at inclination angles 30°, 45° and 60° were investigated. A double-contouring approach with varying processing conditions was employed and surface characteristics were analyzed using data acquired by white light interferometry. The average surface roughness, Sa, surface skewness, Ssk, and percentage area of powder particles attached onto surfaces were statistically evaluated. The lowest Sa obtained for pre- and post-contoured samples is 14.08 µm and 18.88 µm, respectively. For both strategies, the combination of a low laser power and a high scan speed on the interface of downskin surface and underneath powder results in smoother surfaces. However, while comparing both strategies, pre-contouring gives better surface finish for samples built at similar processing conditions, with a difference of nearly 5 µm in Sa.
Realizing the Creep and Damage Effect on Masonry Panel Design Based on Reliability Analysis
Authors: Kim Jung Joong
Published: May 2024

In this study, a masonry panel under a high compressive stress to strength ratio is considered. The panel is modeled as a composite structure by considering a repeated unit cell of mortar and brick. Load redistributions due to creep in mortar and brick as composite materials are accounted for. A step-by-step in-time analysis is performed to calculate the load redistribution in the composite masonry. Time-dependent system reliability analysis of the masonry panel is performed by defining the component and system limit state functions at each time step. While the reliability index of ductile materials depends on the load level in each part of masonry, the reliability index of brittle materials depends only on the overall load. By proposing the reliability index of quasi-brittle materials being between these two reliability index bounds, the reliability index of quasi-brittle materials depends on both the load level in each part and the overall load. Using the proposed reliability index of quasi-brittle materials, partial safety factors for masonry panel design considering creep and damage are calibrated based on the Hasofer and Lind method. A design example using the proposed partial safety factor is presented.
Separation of Adjacent Light Rare Earth Elements Using Silica Gel Modified with Diglycolamic Acid
Authors: Ogata Takeshi , Narita Hirokazu
Published: May 2024

The separation of adjacent rare earth elements (REEs) is a challenging issue due to their chemical similarity. We have investigated the separation of adjacent REEs using four types of adsorbents consisting of silica gel modified with diglycolamic acid with different functional groups at the amide position. For all the adsorbents, the adsorption ratio of REEs increased with the increase in atomic number from La to Sm and then became constant for heavy REEs. Among them, EDASiDGA, an adsorbent containing secondary and tertiary amides, showed a high separation factor for Nd/Pr of 2.8. The EDASiDGA-packed column was tested for individual recovery of Pr, Nd, and Sm. After the adsorption of these REEs from 0.10 M HCl, desorption tests were performed with 0.32 and 1.0 M HCl. As a result, Pr and Nd were eluted separately with 0.32 M HCl, and Sm was recovered with 1.0 M HCl. Since the EDASiDGA-packed column showed excellent separation of Pr/Nd/Sm without any chelating agent, it is promising for practical use.
Experimental Study Based on Box–Behnken Design and Response Surface Methodology for Optimization Proportioning of Activated Lithium Slag Composite Cement-Based Cementitious Materials
Authors: Shao Weixing , Zha Wenhua , Zhou Xueyun , Xu Tao
Published: May 2024

Cement-based cementitious materials occupy a central position in the construction industry, but the problem of high carbon dioxide(CO2) emissions from cement production has attracted global attention. To meet this challenge, finding low-carbon alternative materials has become a top priority in the research of new building materials. At the same time, the problem of large amounts of lithium slag piling up needs to be solved, and resource utilization has become its potential way out. In this study, the volcanic ash activity of lithium slag was activated by composite activation means of high-temperature calcination and sodium silicate, and it was used as an alternative mix to cement. The Box–Behnken design and response surface method (BBD-RSM) was utilized to optimize the ratio of activated lithium slag composite cement-based cementitious materials, and high-performance new solid waste cementitious materials were prepared. The results show that activated lithium slag composite cementitious materials activated lithium slag exhibit excellent performance when activated lithium slag mass fraction is 7.3%, the sodium silicate dosage is 8.8%, and water–solid ratio is 0.6:1. The composite cementitious material under this ratio shows excellent performance, with fluidity 235.69 mm, gelation time 73.54 s, water evolution rate 1.123%, 3d and 28d compressive strengths, respectively, are 11.54 MPa and 22.9 MPa. Compared with ordinary Portland-cement-based cementing materials, the uniaxial compressive strength, modulus of elasticity, and tensile strength at break of activated lithium slag cementitious material solidified body were increased by 34.33%, 36.43%, and 34.98%, and the compressive deformation and tensile deformation were enhanced by 37.78% and 40%. This study not only provides a theoretical basis and experimental foundation for the preparation of new solid waste cementitious materials, but also provides a new solution for the reinforcement of crushed rock bodies in engineering practice, which is of great significance for promoting the low-carbon development of the construction industry.
Improved Dual-Center Particle Swarm Optimization Algorithm
Authors: Qin Zhouxi , Pan Dazhi
Published: May 2024

This paper proposes an improved dual-center particle swarm optimization (IDCPSO) algorithm which can effectively improve some inherent defects of particle swarm optimization algorithms such as being prone to premature convergence and low optimization accuracy. Based on the in-depth analysis of the velocity updating formula, the most innovative feature is the vectorial decomposition of the velocity update formula of each particle to obtain three different flight directions. After combining these three directions, six different flight paths and eight intermediate positions can be obtained. This method allows the particles to search for the optimal solution in a wider space, and the individual extreme values are greatly improved. In addition, in order to improve the global extreme value, it is designed to construct the population virtual center and the optimal individual virtual center by using the optimal position and the current position searched by the particle. Combining the above strategies, an adaptive mutation factor that accumulates the coefficient of mutation according to the number of iterations is added to make the particle escape from the local optimum. By running the 12 typical test functions independently 50 times, the results show an average improvement of 97.9% for the minimum value and 97.7% for the average value. The IDCPSO algorithm in this paper is better than other improved particle swarm optimization algorithms in finding the optimum.
Prediction of Ultimate Bearing Capacity of Soil–Cement Mixed Pile Composite Foundation Using SA-IRMO-BPNN Model
Authors: Xi Lin , Jin Liangxing , Ji Yujie , Liu Pingting , Wei Junjie
Published: May 2024

The prediction of the ultimate bearing capacity (UBC) of composite foundations represents a critical application of test monitoring data within the field of intelligent geotechnical engineering. This paper introduces an effective combinational prediction algorithm, namely SA-IRMO-BP. By integrating the Improved Radial Movement Optimization (IRMO) algorithm with the simulated annealing (SA) algorithm, we develop a meta-heuristic optimization algorithm (SA-IRMO) to optimize the built-in weights and thresholds of backpropagation neural networks (BPNN). Leveraging this integrated prediction algorithm, we forecast the UBC of soil–cement mixed (SCM) pile composite foundations, yielding the following performance metrics: RMSE = 3.4626, MAE = 2.2712, R = 0.9978, VAF = 99.4339. These metrics substantiate the superior predictive performance of the proposed model. Furthermore, we utilize two distinct datasets to validate the generalizability of the prediction model presented herein, which carries significant implications for the safety and stability of civil engineering projects.