The course of COVID-19 in hospitalizef children
Authors:   Shupyk National Healthcare University of Ukraine, Kyiv, Bondarenko A.V. , Volokha A.P. ,   Shupyk National Healthcare University of Ukraine, Kyiv, Palatna L.O. ,   Bogomolets National Medical University, Kyiv, Ukraine,, Kaminska T.M. ,   СNPE «Kyiv Municipal Children’s Infectious Diseases Hospital», Ukraine, Izirinska Y.R. ,   Bogomolets National Medical University, Kyiv, Ukraine,   International European University, Kyiv, Ukraine, Stepanovskyy Y.S. ,   Shupyk National Healthcare University of Ukraine, Kyiv, Lapii F.I. ,   Shupyk National Healthcare University of Ukraine, Kyiv, Savinova K.B. ,   СNPE KRС «Kyiv Regional Children’s Hospital», Boyarka, Ukraine, Patoka V.S. ,   СNPE KRС «Kyiv Regional Children’s Hospital», Boyarka, Ukraine, Kasyan О.I. ,   MNPS «Kyiv City Children Clinical Hospital No.1», Ukraine, Gabrys G.M. ,   MNPS «Kyiv City Children Clinical Hospital No.1», Ukraine
Published: November 2022

Purpose - to study the features of COVID-19 in hospitalized children. Materials and methods. Retrospective multicenter clinical and epidemiological study which includes 328 hospitalized children with laboratory-confirmed COVID-19 for the period from January to August 2021. Results. the highest specific weight among all hospitalized children falls on children of the first year (75/328; 22.8%), in general, early childhood (up to 3 years) accounted for 43% (141/328) of all hospitalizations of children with COVID-19. Common symptoms of the disease included fever, upper respiratory symptoms, intoxication, diarrhea. In 99/328 (30.1%) hospitalized children pneumonia has developed, 50/99 (50.5%) of which needed oxygen support, 10/99 (10.1%) - mechanical ventilation. Pneumonia was most common in children under 1 year, children of the first 5 years of life accounted for more than a half of all pneumonia cases (53/99; 53,5%). 13/328 (3.9%) children were hospitalized to the intensive care unit. Comorbidities including endocrine, oncological, neurological diseases, congenital malformations and others, were noted in 24.6% of hospitalized children. In children with comorbid conditions, pneumonia occurred 2 times more often (relative risk factor RR=1.98, CI 95%), the relative risk of getting into resuscitation RR in the presence of comorbidity is 10.86 (CI 95%). In addition to children with pneumonia, oxygen support or mechanical ventilation required children with obstructive syndrome, pancytopenia, convulsions. The largest proportion of comorbidities in patients hospitalized to the intensive care unit were diseases of the nervous system (congenital malformations of the CNS, cerebral palsy, epilepsy, astrocytoma). Lymphopenia and thrombocytopenia were most commonly associated with severe COVID-19. Conclusions. Children of all ages are susceptible to COVID-19. The main risk factors for severe disease are early age and the presence of comorbid conditions, among which the most relevant are diabetes, obesity, neurological diseases and cancer. The presence of comorbidities in children determines the priority groups for the prevention of coronavirus infection through vaccination. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the Shupyk National Healthcare University of Ukraine. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.