bluuebunny/crossref_metadata_2025 huggingface dataset:
Understanding the Molecular Mechanistic Anthelmintic Potential of Trichosanthes dioica Seed
Authors: Rai Prashant , Malik Jitender K , Siroliya Vinay
Published: June 2024

Background: Herbal treatments have historically been used to cure a variety of human problems. To identify a single element that could be the basis for creating novel, therapeutically effective medicines, researchers examined herbal remedies. The genus Trichosanthes in the family Cucurbitaceae contains an annual or perennial herb that grows in tropical Asia and Australia. The pointed gourd, or parwal (Trichosanthes dioica Roxb), is mostly farmed as a vegetable. T. dioica leaf juice is employed in the treatment of edema, alopecia, subacute liver enlargement, as a febrifuge, and as a tonic. The Charaka Samhita lists fruit and leaf cures for jaundice and intoxication. The pharmacology of the various parts of T. dioica has been the subject of numerous scientific investigations, but some more traditionally important therapeutic benefits are still awaiting scientific confirmation. Aim: In the present study in -vivo and in -silico evaluation of anthelmintic potential of Trichosanthes dioica seed extracts was carried out. Further proposed mechanism of Anthelmintic efficacy of Trichosanthes dioica seed was determined by molecular docking. Method: In the current study, a molecular docking technique was used to try and identify β -tubulin of the helminth’s protein inhibitors. A grid-based docking strategy was used to determine the binding using the Auto Dock software. Merck Molecular Force Field was used to build the 2D structures of compounds, convert them to 3D, and then energetically reduce them up to arms gradient of 0.01. (MMFF). Result: The ethyl acetate extract at 50 mg/mL was the most active against Pheretimaposthuma. The extract exhibited a paralytic effect at 3.0 min and caused actual death at 6.6 min. The PEE, EAE & EE exhibited a dose dependent activity; however, the EAE effect at 50 mg/mL against Pheretima posthuma (earthworm) was not significantly different from that of albendazole, 10 mg/mL. The result of molecular docking was tabulated in table 7, showing binding energy -3.42 & -1.38 kcal/mol for betulin and karounidiol respectively. Conclusion: The anthelmintic potential of T.dioica seed was due to synergetic effect of Betulin and karounidiol via inhibition of the β -tubulin of the helminths.
Biometric Strategies and Performance of Electronic Claim Processing at National Hospital Insurance Fund in Kenya
Authors: Wambua Jacqueline Koki , Mutua Dr. Justice
Published: June 2024

Over the years, there have been concerns about the rising number of fraudsters who work with hospitals to defraud businesses of millions of shillings in fake surgeries and treatments, while health service providers overcharge those who have insurance. To address this issue, medical insurance companies and businesses have implemented biometric authentication systems in collaboration with healthcare providers. The purpose of this study was to determine the effect of biometric adoption strategies on the performance of E-claim processing at NHIF Kenya. The research was guided by four theories that include Technology Acceptance theory, Technology Diffusion theory, and Institutional theory and Performance theory. This study used a descriptive research technique and the target population comprised of 78 senior executives at the NHIF offices in Upper Hill, Nairobi County. A census of 78 respondents was used for the study. The study established that NHIF Kenya had adopted various biometric strategies that included fingerprint recognition systems, Iris recognition strategy and facial recognition. The study concludes that clients expressed high preference with biometric data as it offered high level of security and quick access. NHIF Kenya had over the years realized an increase in operations efficiency, revenue from premium payment and quality delivery of services. It was recommended that NHIF should identify pain points, security vulnerabilities and areas where biometric authentication can be beneficial. The NHIF Kenya should continually evaluate effectiveness of E-claim processing system and should implement advanced fraud detection algorithms.
Early Puerperium Gangrenous Sigmoid Volvulus: Case Report
Authors: Jotham Seth , Magesa Isabela , Mghanga Fabian , Giiti Geofrey
Published: June 2024

Sigmoid volvulus is the third most common cause of colonic obstruction. Men and women are not affected equally and some cases have been reported to occur during pregnancy [1, 2]. The current literatures are still devoid of the cases that occur soon after delivery in the early puerperal period. We present a 37 years’ old female who was brought to St. Francis Regional Referral Hospital (SFRRH) as a referral from nearby health Centre with absolute intestinal obstruction that had an acute onset just one day after her non-eventful spontaneous vertex delivery, she was brought to us on the second day course. On examination she was ill looking with a nasogastric tube insitu that was draining bilious fluid. Her abdomen was grossly distended, hyper-tympanic with an empty rectum on digital rectal examination. She had hypokalemia that was corrected prior surgery and the plane abdominal x-ray showed a gaseous distended colon with a typical coffee bean sign. Intraoperatively a mega distended and a gangrenous sigmoid colon was laying on the rest of the visceral – twisting in a 3600 clockwise direction. A whole of the sigmoid colon was gangrenous of which a total sigmoidectomy was done followed by closure of the rectal stamp and its attachment to the anterior abdominal wall. The lateral to medial descending colon mobilization was done that culminated into placement of the end colostomy. Though noticed and reported during pregnancy, an attention should also be paid to those patients presenting with such obstruction soon after delivery on the early puerperium, this will facilitate early diagnosis and intervention so as to prevent undesirable complications as in the case of this patient.
Pericardial Biopsy in the Etiological Diagnosis of Pericarditis
Authors: Almamy Kéita Mamadou , Abdoulaye Kanté , Daouda Camara , Assitan Koné , Daouda Ouologuem Aly , Amara Coulibaly , Karim Simaga Abdoul , Bréhima Coulibaly , Drissa Traoré , Nouhoum Ongoiba
Published: June 2024

Objective: To evaluate the contribution of pericardial biopsy in the etiological research of pericarditis. Methods: This study was carried out in the University Hospital Centers of Point G and Luxembourg. This was a descriptive study with retrospective collection from January 2012 to May 2015. It concerned all patients operated on for pericarditis in whom the histological examination was carried out. Results: We operated on a total of 70 patients for pericarditis, representing a frequency of 2.3% of all surgical interventions (3044) and 49.6% of cardiac interventions (141). The average age of the patients was 31.5 years with the extremes ranging from 2 years to 84 years. The most common signs of pericarditis were chest pain (27.1%), fever (7.1%) and dyspnea (12.9%). Pericardial drainage was performed in 91.4% of patients. On histological examination, tuberculosis represented 70% and pericardial cancer metastases 4.3%. Immediate post-operative complications were marked by three (03) deaths. Conclusion: The histology of pericardial samples was decisive in the etiological diagnosis. The popularization of biopsy during pericardial drainage is promising in our work contexts.
The Influence of Tetris Block Media on the Concentration of ADHD Children in Tamansari 1 Yogyakarta
Authors: Hana Maria Listyasari Ratih  , Dwi Putri Fatmawati
Published: June 2024

This study aims to determine the effect of Tetris block media on the concentration of ADHD children. The research was conducted at the Tamansari 1 Yogyakarta Inclusive State Elementary School from July to September. The research was carried out using a quantitative approach with the type of experimental research using the Single Subject Research (SSR) method. The data collection technique used one of the ADHD student subjects at the Tamansari 1 Yogyakarta Inclusive State Elementary School. The data collection technique was carried out by observation, measurement of concentration duration, and documentation. This research is a study with an ABA research design by carrying out observation phases before and after intervention and an intervention phase. Data analysis showed changes in results in each phase of the research; in the baseline phase, there was an increase in the duration of stable concentration. Based on these results, it can be concluded that there is an influence of Tetri's block media on the concentration of ADHD children
Effect of the Fun Mathematics Educational Game on the Arithmetic Operation Skills of Children with Dyscalculia
Authors: Hanaa Nuur Aliifah  , Donni Prakosha  , Gunarhadi
Published: June 2024

Students with dyscalculia often struggle to complete math tasks, particularly arithmetic operations involving whole numbers. Therefore, specialized learning methods are necessary, including using the educational game fun mathematics. This study aims to determine the impact of the educational game Fun Mathematics on the ability to perform arithmetic operations with whole numbers in children with dyscalculia. The research method used is experimental with a Group Pretest-Posttest Design. Data analysis was conducted using the Wilcoxon Signed-Rank Test, derived from the pretest and posttest results. The study results show that the average pretest score is 47.43, and the average posttest score is 72.57. This indicates a significant difference in the ability to perform arithmetic operations with whole numbers before and after being given the Fun Mathematics educational game. The T-test analysis results show a significance value of 0.016, indicating that the significance value is less than 0.05. Thus, Ho is rejected, and Ha is accepted. Therefore, it can be concluded that the Fun Mathematics educational game affects the ability to perform arithmetic operations with whole numbers in fourth-grade students with dyscalculia at Al Firdaus Elementary School, Surakarta
Potential Success in English Writing Skills Using Artificial Intelligence “Grammarly”
Authors: Shahriar Arafat , Laboni Fatema Begum
Published: June 2024

Grammarly" is a cloud-based typing assistant or artificial intelli gence that checks for spelling, grammar, punctuation, coherence, interactivi ty, and other errors and replaces them with the appropriate responses. The purpose of the study is to investigate Bangladeshi students’ perception of using Grammarly in their writing to explore AI's potential creditability in effective English writing learning. The participants of the study are 55 students enrolled in different undergraduate programs at Daffodil Interna tional University, Ashulia, Dhaka, Bangladesh. A random sampling technique was used to collect the sample from non-English department students. A questionnaire was developed to gather the information for this research. The study has been conducted through a mixed-method convergent design methodology. The study finds that the participants who use Gram marly or used Grammarly at some point in their lives have developed their writing skills after using Grammarly. The finding of the research strongly discloses the potential success of learning English Writing by using the Artificial Intelligence “Grammarly”. Keywords: Artificial intelligence, Grammarly, Learning, English writing
ENTREPRENEURIAL SKILLS AND UNEMPLOYMENT REDUCTION AMONG YOUTH IN NIGERIA
Authors: Ogunro Victor O  , Akeredolu Adebisi G  , Adedowole Babatope E
Published: June 2024

This study examines the role of entrepreneurial skills in reduction of unemployment among Nigerian youth. Convenience sampling technique was adopted to select (217) graduates in Ondo State. Two research questions were formulated to guide the study which metamorphosed into research hypotheses. The hypotheses formulated were tested using Chi-square (χ2) analysis. A chi-square coefficient (χ2) showed a positive relationship between entrepreneurial development programme on youth unemployment with the value of (x2 =130.291, df=09, p<05).This suggest that an increase in entrepreneurial development programme will reduce unemployment, also significant coefficient of (x2 =131.839, df=09, p<05) suggest that there is strong positive significant relationship between entrepreneurial skills and unemployment reduction. Based on the findings, the study concluded that creativity and skills acquisition are veritable tools for unemployment reduction in Nigeria. Therefore, the study recommends that curriculums should be reviewed to captured skills acquisitions right from the secondary school, also talent development through creativity should be given priority so that talent can now become a source of employment for self-reliance and sustainability.
KEYWORD: Entrepreneur, Entrepreneurial Education, Reduction, Role and Unemployment
Study of axiography changes in patients with temporomandibular joint dysfunction
Authors: Kostiuk Tetiana M. , Hryban Oleksandr M. , Kostiuk Tamara R.
Published: June 2024

Aim: To determine the effectiveness of treatment of temporomandibular joints muscle and joint dysfunction with occlusive splints based on the analysis of axiography data.
Materials and Methods: 274 (two hundred and seventy-four) patients aged 18 to 44 years with a diagnosis of temporomandibular joints dysfunction before and after treatment.
Results: All patients with signs of temporomandibular joints dysfunction before treatment had a violation of the movement trajectory of the lower jaw: deviation – 68.7%, diflexion – 31.3%. When opening and closing the mouth, asymmetric shifts of the lower jaw of more than 2 mm were observed. After treatment with occlusive splints, the correct trajectory of opening and closing the mouth was noted: the number of patients with a trajectory violation decreased by 89.1%, and the amount of displacement of the lower jaw during opening and closing the mouth in 92.4% of patients decreased on average to 0.9 mm. When analyzing the movements of the lower jaw in the sagittal plane, deviations of the trajectory of the lower jaw were found in 79% of clinical cases. After the treatment using occlusive splints, 93.4% of cases of mandibular movement trajectory violations in the transversal plane were eliminated, and 78.1% of patients had a reduction in displacement volume to 0.9 mm. When analyzing the movements of the lower jaw in the sagittal plane, deviations of the trajectory of the lower jaw were found in 79% of clinical cases. After the treatment using occlusive splints, 93.4% of cases of mandibular movement trajectory violations in the transversal plane were eliminated, and 78.1% of patients had a reduction in displacement volume to 0.9 mm.
Conclusions: Movement trajectories of the lower jaw in the sagittal plane improved in 80.1% of patients, normalization of the position of the lower jaw in relation to the neuromuscular trajectory was achieved in 93.4% of clinical cases. According to the analysis of the parameters, this treatment should be considered effective.
Morbidity and prevalence of diseases of the circulatory system in the adult population of the Kyiv region, including the working-age population
Authors: Ivaniuk Anatolii V.
Published: June 2024

Aim: To analyze the incidence and prevalence of diseases of the circulatory system in the adult population of the Kyiv oblast region, including the able-bodied population.
Material and Methods: Medical history records on cardiovascular diseases were the materials, and statistical methods of medical and social data procession were used in the study.
Results: The distribution of cardiovascular diseases in the adult population of the Kyiv oblast region was highlighted. The districts with the lowest and highest rates of myocardial infarction, strokes, ischemic disease and hypertension were found. The trends in relevant morbidity were described.
Conclusions: When analyzing data from statistical reporting, it was established that before the start of a full-scale invasion and partial quarantine restrictions due to the spread of SARS-CoV-2, the incidence of diseases in the circulatory system was characterized by significant unevenness across administrative units. However, a specific area with the highest morbidity was not singled out, only in respect of which it would be necessary to carry out measures to improve the provision of medical cardiology care. In general morbidity, areas with the highest levels of morbidity were established, which need to improve the provision of cardiac care, as this is a negative socio-economic factor with the need for intervention measures.
Asthma in patients with the syndrome of undifferentiated dysplasia of connective tissue: peculiarities of the course or mutually aggravating mechanisms?
Authors: Solyeyko Olena V. , Chernykh Mariia O. , Iliuk Iryna A. , Baranova Iryna V. , Romash Iryna B. , Berezovskyi Arthur M. , Soleiko Larysa P.
Published: June 2024

Aim: To analyse laboratory and biochemical features of the severe persistent course of asthma in patients with undifferentiated connective tissue dysplasia (UCTD) syndrome, and their phenotypic and visceral stigmas of dysembryogenesis.
Materials and Methods: We enrolled 60 male patients with asthma, aged from 23 to 62 years (mean age (46.83 ±0.85) years): 30 patients with the background of UCTD, and 30 - without UCTD. We analysed clinical, somatometric, surveying (original questionnaire based on the phenotypic map of Glesby), instrumental (spirography, echocardiography, endoscopy, esophagofibrogastroduodenoscopy) and laboratory (including eosinophilic granulocytes and aldosterone levels) data.
Results: Correlations were found in men with UCTD between the number of UCTD markers and rate of earlobe diagonal fold (r=+0.75; р<0.05), asthenic constitution (r=+0.72; р<0.05), easy bruising (r=+0.7; p<0.05) and straight abdominal line hernia (r=+0.52; p<0.05). Average aldosterone serum level in patients with UCTD (176,10 ±11,22) was significantly higher than in those without UCTD (142,77 ±± 9,43), (p<0.05), as well as average eosinophils levels (1.3 ±0.25 vs. 0.57 ±0.12, p<0.05). In the absolute majority of patients with UCTD (93.3%) asthma onset was confirmed after pneumonia, and their age of asthma manifestation was significantly higher (37.2 ±1.21) than in patients without UCTD (21.4 ±1.13). Also, in patients with UCTD there was a high number of severe exacerbations during the last year (2.7 ±0.12 per year) on the background of high doses of combined inhaled glucocorticosteroids use.
Conclusions: Identified “phenotypic profile”, clinical and biochemical features of patients with asthma on the background of UCTD syndrome, which determine the severe course and early formation of asthma complications, will further accelerate the diagnosis of this asthma phenotype and improve approaches to the selection of treatment regimens for these patients.
Environmental competencies for healthcare management at a 2nd education level as a component of strategic management
Authors: Turianytsia Solomiia M. , Yurochko Tetiana P. , Balashov Kostyantyn V. , Hulchiy Olesya P.
Published: June 2024

Aim: To present the results of the analysis of educational standards and curricula of the second educational level of training of specialists, who may be managers of healthcare, on the content of the environmental component as an element of strategic management.
Materials and Methods: Content analysis 24 educational standards of the Ministry of Education and Science of Ukraine of Ukraine for 6 fields of knowledge and 200 master’s curricula from 87 institutions of higher education of Ukraine.
Conclusions: There is a distribution of basic leadership and management competencies both by types of these competencies and between specialties. The requirements for the inclusion of the environmental component in the framework documents are poorly expressed. The content of environmental issues in the curricula is insufficient.
INTEGRATION OF ISLAMIC SCIENCES ACCORDING TO M. AMIN ABDULLAH AND ITS IMPLICATIONS FOR ISLAMIC UNIVERSITIES
Authors: Ayu Adinda , Permatasari Devi , Maulida Haliza Salma
Published: June 2024

This research aimed to describe the integration of Islamic sciences according to Prof. M. Amin Abdullah and its implications for Islamic universities. The research methods used were library research and bibliographic research. According to Amin, the integration of Islamic knowledge was an essential issue in the development of Islamic knowledge in Indonesia, especially in Islamic religious universities. Amin's reflections emphasized the need for an integrated and interconnected approach to Islamic science, which until now was still fragmented and disconnected from contemporary issues. Amin's theory was based on the classification of Islamic knowledge into four categories: al Qur'an, Sunnah, 'Ulum al Din, al-Fikr al Islamy, and Dirasah al Islamiyyah. These categories corresponded to the concept of a four-layer spider's web, which combined all social and religious principles to solve contemporary problems.
Modelo de factores proximales para la ideación suicida de estudiantes universitarios mexicanos
Authors: Lievanos-Ruiz Francisco Javier , González Betanzos Fabiola , Hermosillo de la Torre Alicia Edith , Sanchez-Loyo Luis Miguel
Published: June 2024

Los estudiantes universitarios son considerados un grupo vulnerable a la presencia de ideación suicida. El objetivo de este estudio fue analizar la bondad de ajuste de los principales factores proximales y contextuales a partir del modelo biopsicosocial sobre la ideación suicida de Turecki en una muestra de estudiantes universitarios de la región centro-occidente de México. Se evaluaron la ideación suicida y los principales factores proximales y contextuales del modelo, así como la función familiar en 165 estudiantes universitarios. Se analizó la bondad de ajuste de los factores de riesgo proximales y contextuales sobre la ideación suicida utilizando un modelo de ecuaciones estructurales. Se observó un excelente ajuste absoluto e incremental y un adecuado ajuste de parsimonia en el modelo propuesto. Se identificaron como factores de riesgo: el aislamiento social, la desregulación emocional, síntomas depresivos, desesperanza y la función familiar. Se concluye que el ajuste del modelo propuesto sugiere que estos factores proximales y contextuales pueden ser utilizados como referentes para la identificación y abordaje de la ideación suicida en estudiantes universitarios.
Dampak Pembiayaan Kredit Usaha Rakyat (KUR) Terhadap Return on Asset (ROA) Pada BRI Syariah Periode 2019-2023
Authors: Ropik Yunus Dede , Supriyanto Dodi , Hasanah Nurul
Published: June 2024

Dukungan pemerintah terhadap perkembangan UMKM salah satunya diwujudkan dengan memberikan kemudahan kepada pelaku UMKM untuk memperoleh bantuan pinjaman modal. Dalam mengimplementasikan kemudahan pembiayaan tersebut pemerintah menugaskan berbagai bank untuk menyalurkannya, diantaranya adalah BRI Syariah. Tujuan dari penelitian ini adalah untuk meninjau (1) pertumbuhan kredit usaha rakyat (KUR) selama periode 2019-2023, (2) return on asset (ROA), dan (3) menganalisis pengaruh pembiayaan KUR terhadap ROA.
Metode deskriptif dan verifikatif menjadi metode yang dilakukan dalam penelitian ini, dimana data yang digunakan berupa data sekunder laporan keuangan BRI Syariah periode 2019-2023, serta dengan data primer melalui studi kepustakaan dan dokumentasi. Uji asumsi klasik, regresi linier, koefisien korelasi, dan koefisien determinasi merupakan alat statistika yang digunakan untuk menganalisis pengaruh antara variabel, setelah sebelumnya dilakukan uji asumsi klasik.
Penelitian ini menyimpulkan bahwa (1) perkembangan pembiayaan UMKM selama 5 (lima) tahun mengalami grafik yang fluktuatif, (2) senada dengan poin 1, pertumbuhan ROA dari tahun 2019-2023 pun mengalami pasang surut, sehingga (3) pembiayaan KUR mempunyai hubungan yang positif terhadap ROA, dan pembiayaan KUR mempunyai pengaruh sebesar 42,8% terhadap ROA.
Biodegradable Cutting Fluids Evaluation for Sustainable Machining Processes
Authors: Wofuru-Nyenke Ovundah
Published: June 2024

Sustainably selecting the best cutting fluid among alternatives, considering various weighted criteria or factors, is a complex problem encountered by machine operators in engineering workshops worldwide. The aim of this work is to utilize the Multi-attribute Utility Theory (MAUT) decision-making model for biodegradable cutting fluids selection in a machine shop. The objectives of the work include carrying out a step-by-step process of the MAUT method on biodegradable cutting fluid alternatives. Therefore, this study utilizes the MAUT decision-making method for selecting the best biodegradable cutting fluid among a set of five (5) alternatives namely soybean oil, palm oil, polyalphaolefin, trimethylpropane trioleate and polyethylene glycol. The cutting fluids were evaluated based on criteria such as heat dissipation, stability, lubrication and cost-effectiveness. From the results, Polyalphaolefin is the best alternative, ranking first according to the global utility scoring. Therefore, Polyalphaolefin had a global utility score of 0.688, followed by Polyethylene Glycol which had a score of 0.600, followed by Trimethylpropane Trioleate which had a score of 0.588, followed by Soybean Oil which had a score of 0.363 and finally, Palm Oil which had a score of 0.263.  This study provides a procedure for implementing the MAUT method of decision-making for cutting fluids selection within engineering workshops for sustainable machining practices.
Metabolic adaption of epithelial cells in asthma: a window to the initiation of carcinogenesis?
Authors: Dymond Thomas
Published: June 2024

Recent data has resulted in an interest in the metabolic shift in cellular metabolism to aerobic glycolysis, increased reactive oxygen species (ROS), and mitochondrial dysfunction associated with asthma. There has been a push to better understand the immune and metabolic changes in allergy to improve understanding of disease pathology and treatment. Aerobic glycolysis seen in epithelial cells in asthma promotes chronic inflammation and the production of inflammatory cytokines. Asthma epithelial cells share a number of features proposed in the stages of cancer initiation including aerobic glycolysis and increased apoptosis with proliferation, all within a chronic inflammatory microenvironment. Metabolic reprogramming in malignant cells has been widely investigated since the glycolytic characteristics were first described last century. It is still debated whether these metabolic changes are the cause or consequence of carcinogenesis and oncogenic cell-selective pressures. Although historic results have been conflicting, recent data has found an increased lung cancer risk in asthma patients, independent of risk factors. A review of emerging research on the metabolic changes seen in asthma helps us to propose a pathway between the initiation of aerobic glycolysis and the selective pressures of the epithelial microenvironment and resulting malignant transformation risk.
Strategi Meningkatkan Literasi Membaca Siswa Sekolah Dasar Melalui Pengadaan Pojok Baca di Kelas
Authors: Santuni Bela , Dalem Kadek Bisma Taruna , Murtini Kadek Dwi , Putra I Putu Pur Adi , Juliwantara Gede , Werang Basillius Redan
Published: June 2024

This research aims to increase the reading literacy of elementary school students by providing a reading corner in the classroom at SD Negeri 1 Banjar Tegal, Buleleng. Using qualitative research methods, data was collected from primary and secondary data sources. Primary data sources include direct classroom observations and in-depth interviews with teachers and students, while secondary data sources are obtained from analysis of documents related to literacy programs and school policies. Data collection techniques include observation, interviews and document study. Data analysis was carried out using a qualitative descriptive approach, through the stages of data reduction, data presentation and drawing conclusions. The research results showed that providing a reading corner equipped with varied and interesting books significantly increased students' interest and reading ability. Teachers who actively direct and motivate students to use the reading corner also make a positive contribution. The conclusion of this research is that reading corners are effective in creating a supportive reading environment, and collaboration between schools, teachers, and parents is critical to the success of this program. These findings can be a reference for other schools in implementing similar strategies to improve students' reading literacy.
Disboyizisin Önlenmesi ve Sağlıklı Mikrobiyota Gelişimi için Probiyotikler
Authors: Çakır Adem , Arslan Müge , Sadioğlu Özgür Deniz , Akdemir Tarık , Az Adem , Güven Şirin , Ümit Tuba Betül , Şamlı Mücahide , Çalık Mustafa , Coşkun Abuzer , Alkan Mehmet Oktay , Altınbilek Ertuğrul , Avcı Akkan , Avcı Begum Şeyda , Hacıosman Oğuzhan , Mülayim Şeyma Nur , Özbaltan Özlem Canan , Doğan Mukaddes , Doğan Serkan , Basa Kalafat Ayşe Fethiye , Demirci Burak , Akın Burak
Published: June 2024

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Cell-Free Protein Synthesis with Technical Additives – Expanding the Parameter Space of In Vitro Gene Expression
Authors: Bartsch Tabea , Lütz Stephan , Rosenthal Katrin
Published: June 2024

Biocatalysis has established itself as a successful tool in organic synthesis. A particularly fast technique for screening enzymes is the in vitro expression or cell-free protein synthesis (CFPS). The system is based on the transcription and translation system of an extract donating organism to which substrates like nucleotides and amino acids, as well as energy molecules, salts, buffer, etc. have to be added. After successful protein synthesis, further substrates can be added for an enzyme activity assay. mimicking of cell like conditions is one approach for optimization, the physical and chemical properties of CFPS are not well described yet. To date, mainly standard conditions have been used for CFPS, with little systematic testing of whether conditions closer to intracellular conditions with regards to viscosity, macromolecules, inorganic ions, osmolarity, or water content are advantageous. Also, no non-physiological conditions have been tested to date that would expand the parameter space in which CFPS can be performed. In this study, properties of an Escherichia coli extract based CFPS system are evaluated, and the parameter space is expanded to high viscosities, concentrations of inorganic ions and osmolarity using ten different technical additives including organic solvents, polymers, and salts. It is shown that the synthesis of two model proteins, namely superfolder GFP (sfGFP) and the enzyme truncated human cyclic GMP-AMP synthase fused to sfGFP (thscGAS-sfGFP), is very robust against most of the tested additives.
Penerapan Nilai-Nilai Agama Islam dalam Kegiatan Olahraga
Authors: Salahudin Salahudin
Published: June 2024

Menerapkan prinsip-prinsip Islam dalam olahraga memiliki peranan signifikan dalam membentuk karakter atlet yang baik dan tangguh. Penelitian ini merupakan menelitian studi literatur yang bertujuan menganalisis berbagaimacam literatur yang ada. Beberapa nilai-nilai islami yang dapat diterapkan dalam konteks olahraga mencakup keyakinan dan ketaqwaan kepada Allah, kedisiplinan, kerja keras dan ketekunan, kepedulian sosial, keadilan, kesabaran dan ketenangan batin, serta sikap rendah hati. Dengan mengaplikasikan nilai-nilai agama Islam dalam olahraga, atlet dapat mengembangkan karakter yang sehat dan positif, serta ikut membantu menciptakan suasana harmonis dan damai di dunia olahraga. Selain itu, nilai-nilai agama Islam juga mampu membantu atlet dalam menghadapi tantangan dan ujian ketika berkompetisi, serta menjaga fokus dan menghargai fair play dalam olahraga. Oleh karena itu, bagi atlet Muslim, sangat penting untuk mempelajari dan menerapkan nilai-nilai agama Islam dalam konteks olahraga. Hal ini tidak hanya berdampak pada peningkatan kinerja atlet, tetapi juga memperkuat karakter pribadi dan keislaman atlet.
El Reciclaje como Recurso Didáctico para la Enseñanza de la Dimensión Cognitiva en la IE Cotoca Arriba
Authors: Negrete Blanco Johana Paola , Doria Osorio Saray Sofía , Garavito Campillo Erica
Published: June 2024

El presente artículo es el resultado de una investigación la cual mira el reciclaje como un proceso de reflexión para toda la sociedad, se busca con este proceso el cuidado y protección del medio ambiente, este se puede utilizar en los entornos educativos para enseñar de una forma didáctica. Partiendo desde este punto, esta investigación tiene como objetivo implementar el reciclaje como recurso didáctico para la enseñanza de la dimensión cognitiva en los niños de preescolar del Centro Educativo Cotocá Arriba. Esto permitirá al niño disfrutar de una enseñanza didáctica, un ambiente sano y recreativo, potenciando así sus habilidades y destrezas. Metodológicamente se define como una investigación cualitativa de tipo investigación acción y participativa (IAP), investigación hecha con un total de una población de 15 niños y un docente de esta institución que, a partir de un análisis de distintas referencias bibliográficas, permitirá observar cómo las docentes imparten una enseñanza hacia los estudiantes por medio de estos recursos creados a partir de materiales reciclados.
Cor Pulmonale Agudo y Comunicación Interauricular de Posible Neoformación en paciente con ahogamiento. Reporte de un Caso
Authors: Peña Jiménez Wilson Hipólito , Vélez Paez Jorge Luis , Ganchala Padilla Marcia Karina , Oña Pachacama Jean Jorge , Peña Jiménez Nixon Ronaldo
Published: June 2024

El ahogamiento es una de las principales causas de muerte incidental en el mundo, la cual se manifiesta como la injuria cardiorrespiratoria sufrida por inmersión/sumersión. El tiempo es un factor clave en la supervivencia, pronóstico y daño neurológico. A pesar de que el distrés respiratorio e hipoxia es el cuadro predominante puede presentarse otras complicaciones multisistémicas. Objetivo: Identificar de manera oportuna los fenómenos fisiopatológicos del síndrome de ahogamiento, para su adecuado manejo integral asegurando la supervivencia y evitar secuelas. Descripción del caso: Paciente femenina de 2 años de edad, sin comorbilidades, que recibió RCP básico durante 5 minutos logrando retorno a la circulación espontánea por ahogamiento con una puntuación de Szpilman de 6 puntos y cor pulmonale agudo, que generó una probable comunicación interauricular tipo ostium secundum. Conclusiones: Los cambios generados por el síndrome de ahogamiento, desarrollan una marcada discordancia de la ventilación perfusión manteniendo una hipoxia tisular, debido al aumento de las resistencias vasculares pulmonares, afectando la función ventricular derecha, pudiendo condicionar situaciones extremas, como la reapertura septal auricular, la cual, se diagnostica mediante la ecocardiografía transtorácica o transesofágica.
Escribir Bien para Comprender Mejor
Authors: Campo Vargas Yesica Milena , Chávez Cuetocué Shyrley Dhayana , Gutiérrez Cuene Adriana María
Published: June 2024

El propósito de este estudio es implementar el método Lemalin, basado en juegos didácticos, para mejorar la producción textual a nivel inferencial y crítico entre los estudiantes de Quinto B de la Institución Educativa Escuela Normal Superior de Tierradentro "Enrique Vallejo". La meta es que los estudiantes alcancen los desempeños académicos esperados durante el año escolar y superen las dificultades de comprensión relacionadas con la escritura. La metodología empleada es cualitativa, con un diseño de investigación-acción, utilizando técnicas de observación y encuestas aplicadas a 22 estudiantes durante las etapas de diagnóstico y evaluación. Los principales resultados indicaron que la mayoría de los estudiantes no escribe con regularidad y algunos tienen dificultades para generar ideas al escribir. En contraste, hay estudiantes que disfrutan de la escritura, revelando problemas en la actitud hacia la escritura, en las técnicas de generación de ideas y en las oportunidades para escribir en clase. Para abordar estos problemas, se desarrolló un proceso didáctico basado en juegos que fomentó la creatividad y la comunicación escrita. En conclusión, el estudio establece que el aprendizaje de la escritura es un proceso integral que abarca tanto habilidades cognitivas como motivacionales y técnicas.
Plan de Capacitación para la Mejora de las Competencias Inclusivas Docentes en Educación Primaria en Antioquia
Authors: Muñoz Alegría Ruth Carolina , Moreno Rengifo Yeriza , Manjarres Penagos Luz Iris
Published: June 2024

Las competencias inclusivas docentes se refieren a las habilidades, conocimientos y actitudes que los educadores necesitan poseer para crear entornos de aprendizaje que sean accesibles, equitativos y acogedores para todos los estudiantes, independientemente de sus características individuales, capacidades o contextos socioculturales. Ene se sentdo, el estudio se centró en diseñar un programa de capacitación para mejorar las competencias de los maestros de primaria en la promoción de la educación inclusiva en la Institución Educativa Luis Eduardo Díaz, ubicada en La Patria, Antioquia. Este programa se fundamentó en un enfoque cualitativo, priorizando una comprensión profunda de las experiencias, percepciones y prácticas de los docentes en relación con la educación inclusiva. El objetivo fue crear un plan de capacitación que atendiera las necesidades específicas de los maestros y fomentara una mayor inclusión en el entorno educativo. Los resultados mostraron que los docentes valoran y comprenden la importancia de la educación inclusiva, y la mayoría ha recibido capacitación en este ámbito de diversas maneras. No obstante, en la práctica pedagógica y didáctica dentro del aula, no perciben un impacto significativo, lo que evidencia una falta de conocimientos concretos sobre cómo aplicar la educación inclusiva de manera efectiva. A raíz de esto, se propuso y desarrolló un plan de capacitación que aumentó los conocimientos de los docentes y creó un espacio para el intercambio de ideas y experiencias relacionadas con la educación inclusiva dentro de la institución.
P Perancangan Tata Letak Gudang Barang Jadi Produk Jilbab Dengan Metode Class Based Storage Dan Penataan Ergonomis CV Jilbab Surabaya
Authors: Mohamad Syihabul Akbar
Published: June 2024

CV Jilbab Surabaya merupakan perusahaan yang membuat dan menjual Jilbab Segiempat, Jilbab Pashmina, Jilbab Bergo, dan lainnya. Gudang penyimpanan mempunyai dimensi dengan panjang 17 m, lebar 8m, dan tinggi 6 m.  Mengetahui penyusunan layout usulan dengan metode class based storage, mengetahui waktu penataan produk, dan mengetahui dengan adanya investasi rak dan tenaga kerja menggunakan simulasi flexsim. Kegiatan kerja penelitian ini dilaksanakan selama 4 bulan dimulai pada tanggal 1 Oktober 2023 sampai dengan 31 Januari 2024. Dari hasil pengolahan klasifikasi ABC pada 20 jenis produk jilbab pada penyimpanan barang jadi pada CV Jilbab Surabaya : kelas A 68,92%, 26 produk, kelas B 14,72%, 8 produk, dan kelas C 16,09%, 11 produk. Pada layout usulan menggunakan flexsim didapatkan rata – rata waktu menunggu pada ketiga karyawan sebesar 7,07 detik dengan penataan barang yang tertata rapi dengan menggunakan metode class based storage.
Human Capital Venture and Financial Development in Thailand: The Part of Instruction and Wellbeing
Authors: Krimjai Chanyanat , Sopapimuk Sophat , Reamee Sujitra , Thongsrisuk Pranee , Sirakunprasert Paweerisa
Published: June 2024

Human capital investment and economic growth in Thailand: the role of education and health. This research aims to study the direction and trend of growth in Thailand: the role of education and health. And to study guidelines for preparing personnel in the human resources department for growth in Thailand: the role of education and health. Investing in human capital In this research, related theories and literature were studied including: Rogoza et al. (2018), Jayawickreme et al. (2020) , Moghadam et al. (2020) , Obschonka et al. (2020). The research methodology is study of investing in human capital and the economy Growth in Thailand: The Role of Education and Health This research has been carried out since studying basic information on the direction and trend of growth in Thailand: The Role of Education and Health and studying guidelines for preparing personnel in the human resources department. Growing up in Thailand: The role of education and health in 2017-2023 By collecting data, this research uses secondary data related to education, health, economic growth and other factors. that are panel data from the World Bank, including world development indicators (World Development Indicators: WDI), education statistics and demographics, nutrition, and health statistics during 2017-2023, subject to data limitations. The comes about of the ponder found that the chunk of ice demonstrate for quality takes the assistance of an ice sheet which has fair a portion of its volume over water and the rest remains beneath the surface within the ocean to clarify the concept of person quality. The structure is appeared in Figure 1. Essentially, a quality has a few components unmistakable like essential information and fundamental abilities, which are simple to get it and degree and moderately simple to alter and create through preparing. Be that as it may, other components underneath the surface counting social parts, self-image, characteristics, and inspiration are inalienable and troublesome to degree. Information and abilities over water surface can be characterized as the benchmark quality. Rogoza et al. (2018) distinguished components of quality covered up profoundly as the separating quality, such as the inside drive, social inspiration, identity quality, self-image, demeanor, self-esteem, narcissism, and self-worth. Related to information and aptitudes, separating qualities are not simple to be watched and measured and troublesome to alter and assess.
The Privilege of ‘Not-Knowing’: Clarice Lispector’s
A hora da estrela
as Self-Critique
Authors: GARONZIK REBECCA
Published: June 2024

Clarice Lispector’s
A hora da estrela
is primarily a work of self-critique. As in several of Lispector’s earlier texts, the theme of ‘not-knowing’ as a method of spiritual transcendence forms an integral part of the narrative. What distinguishes
A hora da estrela
is the fact that through the marginalized figure of Macabéa, Lispector intertwines the theme of not-knowing with its less-attractive underside: naïveté and ignorance. In the novel Lispector reveals how Macabéa’s not-knowing/ artlessness limits her life choices and leaves her more vulnerable to abuse. Within the multilayered fabric of this metafictional text, the spiritual and philosophical not-knowing that serves as the focus of Lispector’s earlier questing novels forms a part of what is being reassessed. Thus, in her final hours Lispector critiques the privilege inherent in her previous questing works and wholeheartedly engages with the ways that issues of class intersect with questions surrounding the purpose and value of artistic expression.
Pluoštinių kanapių spalių garso sugerties ir garso perdavimo sumažėjimo tyrimai
Authors: Strazdas Edgaras , Januševičius Tomas
Published: June 2024

Atsižvelgiant į globalias tvarumo tendencijas, sintetinės garsą slopinančios medžiagos vis dažniau keičiamos natūralios kilmės medžiagomis. Viena iš tokių medžiagų – pluoštinės kanapės. Nors pasaulyje kanapių pluoštas ir spaliai yra pakankamai gerai ištirti, mokslininkai akcentuoja tyrimų poreikį atskirai kiekvienam regionui, kur auginamos pluoštinės kanapės, nes jų savybės labai skiriasi dėl aplinkos sąlygų įtakos įvairiose jų auginimo vietovėse. Šio tyrimo tikslas – ištirti Lietuvoje užaugintų pluoštinių kanapių spalių, spalių ir pluošto mišinio bei spalių blokelio garso sugerties ir garso izoliavimo savybes ir jų priklausomybę nuo tiriamų bandinių storio ir tankio. Eksperimentiniai tyrimai atliekami vadovaujantis standartiniais metodais ISO 10534-2 ir ASTM E2611-17. Nustatyta, kad didesnio storio kanapių spalių ir kanapių spalių su pluoštu bandiniai geriau sugeria garsą vidutiniuose ir žemuosiuose dažniuose. 150 kg/m3 tankio bandiniai daugeliu atvejų geriau sugeria garsą visame dažnių diapazone, lyginant su to paties storio 100 kg/m3 tankio bandiniais. Sumaišius kanapių spalius su dekortikuotu kanapių pluoštu, pagerėjo garso sugertis visoje dažnių juostoje.
Rišiklio įtakos padangų tekstilės pluošto kompozitinių plokščių garso sugerčiai tyrimas ir vertinimas
Authors: Ružickij Robert , Grubliauskas Raimondas
Published: June 2024

Vykdant veiklą didelėse patalpose dažnu atveju susiduriama su nepakankamu akustiniu komfortu. Įvairūs sprendiniai yra taikomi, siekiant pagerinti akustines sąlygas. Pakabinamos lubos ir mineralinių vatų plokštės yra vieni iš būdingiausių sprendinių, kaip galima pagerinti patalpų akustinį komfortą. Tačiau, gaminant tokias plokštes, yra naudojami gamtiniai ištekliai ir eikvojami dideli energijos kiekiai. Padangų tekstilės pluoštas – tai atlieka, kuri gaunama perdirbant nebetinkamas naudoti padangas. Kartu su rišamąja medžiaga būtų sukurta kompozitinė garsą sugerianti plokštė, kuri būtų mažiau taršesnė alternatyva plačiai naudojamoms mineralinėms vatoms. Šio tyrimo tikslas yra ištirti, kokią įtaką akustinėms savybėms daro didėjantis rišamosios medžiagos kiekis kompozite. Garso sugerties koeficiento nustatymo metodas paremtas standartiniu metodu, aprašytu ISO 10534-2 standarte. Tyrimo rezultatai parodė, kad, didėjant rišamosios medžiagos kiekiui kompozite nuo 10 iki 50 %, garso sugertis visame spektre mažėja vidutiniškai nuo 4 iki 30 % (kuo didesnis rišiklio kiekis, tuo labiau mažėjo garso sugertis). Gauti rezultatai rodo, kad rišiklio kiekis kompozite lemia kompozitinės garsą sugeriančios plokštės garso sugerties gebą.
Gemini Near Infrared Spectrograph−Distant Quasar Survey: Rest-frame Ultraviolet−Optical Spectral Properties of Broad Absorption Line Quasars
Authors: Ahmed Harum , Shemmer Ohad , Matthews Brandon , Dix Cooper , Ha Trung , Richards Gordon T. , Brotherton Michael S. , Myers Adam D. , Brandt W. N. , Gallagher Sarah C. , Green Richard , Lira Paulina , McLane Jacob N. , Plotkin Richard M. , Schneider Donald P.
Published: June 2024

We present the rest-frame ultraviolet−optical spectral properties of 65 broad absorption line (BAL) quasars from the Gemini Near Infrared Spectrograph−Distant Quasar Survey (GNIRS-DQS). These properties are compared with those of 195 non-BAL quasars from GNIRS-DQS in order to identify the drivers for the appearance of BALs in quasar spectra. In particular, we compare equivalent widths and velocity widths, as well as velocity offsets from systemic redshifts, of principal emission lines. In spite of the differences between their rest-frame ultraviolet spectra, we find that luminous BAL quasars are generally indistinguishable from their non-BAL counterparts in the rest-frame optical band at redshifts 1.55 ≲ z ≲ 3.50. We do not find any correlation between BAL trough properties and the Hβ-based supermassive black hole masses and normalized accretion rates in our sample. Considering the Sloan Digital Sky Survey quasar sample, which includes the GNIRS-DQS sample, we find that a monochromatic luminosity at rest-frame 2500 Å of ≳1045 erg s−1 is a necessary condition for launching BAL outflows in quasars. We compare our findings with other BAL quasar samples and discuss the roles that accretion rate and orientation play in the appearance of BAL troughs in quasar spectra.