bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluación de atractivos naturales y senderos existentes en la Reserva Florística Manejada Monte Natural Cupaynicú para una nueva propuesta de rutas turísticas
Authors: Ramón Puebla Adonis Maikel , Arévalo Rodríguez Carlos Manuel , Salinas Chávez Eduardo , Millán Estriche Mercedes
Published: January 2024

Inventariar y evaluar los atractivos naturales de la Reserva Florística Manejada Monte Natural Cupaynicú constituye el objetivo principal de esta investigación. Para alcanzarlo se examinan siete atractivos naturales y cinco rutas de senderos propuestas para el desarrollo del turismo de naturaleza. Por medio de distintas metodologías se valoraron los senderos existentes mediante el inventario de los recursos del área, la clasificación, jerarquización y evaluación tanto de los atractivos naturales existentes y la adición de dos nuevos detectados al realizar el trabajo de campo. También se evaluaron los accesos y el estado que guarda el área protegida. Para proponer dos nuevas rutas de senderos y la eliminación de las cinco existentes por presentar problemas asociados con su diseño y vinculación con los atractivos. Esta propuesta final será incorporada al Programa de Uso Público y al Plan de Manejo del área protegida.
Análisis de la dimensión ambiental en la Licenciatura en Desarrollo Turístico Sustentable (LDTS) de la Universidad de Guadalajara (México).
Authors: Martínez Ibarra Jorge Arturo , Arellano Montoya Rosa Elena
Published: January 2024

El presente trabajo realiza un análisis de la dimensión ambiental presente en la formación profesional de la Licenciatura en Desarrollo Turístico Sustentable (LDTS) de la Universidad de Guadalajara (México). La investigación realizada fue descriptiva y exploratoria mediante la revisión del Plan de Estudios, la caracterización de las Escuelas de Campo, el análisis de dos proyectos extracurriculares que fungen como apoyo a los contenidos programáticos y un sondeo con veinte egresados de la LDTS seleccionados aleatoriamente. Como resultado se identificaron las Unidades de Aprendizaje que presentaron contenidos ambientales, las categorías y características de las Escuelas de Campo, el aporte de los proyectos extracurriculares a la generación de nuevas capacidades de los estudiantes, las percepciones de los egresados respecto a la calidad de su formación profesional, las materias que consideraron más relevantes y la aplicación de los conocimientos ambientales adquiridos en el ámbito laboral. Se concluye que las Escuelas de Campo, las Prácticas Escolares y los Proyectos Extracurriculares juegan valioso papel como puente entre la teoría y la práctica; que los egresados consideraron valiosos y útiles los conocimientos ambientales recibidos durante su formación académica, aunque aún se presentan carencias en el proceso; que se requiere lograr una mayor transversalidad del concepto de “lo ambiental” en la Licenciatura y; que el diseño curricular de la LDTS que buscó generar un enfoque innovador del turismo continúa constantemente en un proceso de construcción.
La investigación turística mexicana indexada en Web of Science: un análisis bibliométrico y relacional
Authors: Corral Marfil José Antonio , Vargas Vázquez Ástrid , Rodríguez Herrera Ismael Manuel
Published: January 2024

El objetivo de estudio es explorar las características de la producción científica mexicana sobre turismo indexada en la base de datos Web of Science, a través de un análisis bibliométrico y de redes sociales de los artículos publicados en revistas especializadas en turismo entre 1994 y 2021. Se estudian la evolución de la producción, los tipos de revistas, los autores clave, las organizaciones más productivas, la colaboración internacional, los rasgos de la red social de coautoría, las temáticas abordadas, así como las citas recibidas y emitidas. Los resultados arrojaron un total de 430 artículos, publicados en 49 revistas, por 732 autores afiliados a 173 organizaciones de 24 países. Se pone de manifiesto que la investigación turística mexicana tiene una presencia apreciable y creciente en el Web of Science, aunque también una cierta dualidad: la mayor parte se publica en español en revistas iberoamericanas indexadas en el Emerging Sources Citation Index, mientras que solo una parte minoritaria se publica en inglés en revistas indexadas en el Social Sciences Citation Index, a menudo mediante colaboraciones internacionales, con un mayor impacto científico internacional.
¿Sueñan los algoritmos con ser artistas? Una reflexión filosófica en torno al arte algorítmico
Authors: Hernández-Tisnado Yazmín Elena
Published: January 2024

El futuro es una bestia indómita, sobre todo a la luz de los avances científicos y tecnológicos contemporáneos, pues tal y como señala Miguel Ángel Quintanilla en su obra Tecnología: un enfoque filosófico, “el mundo que queremos construir no depende tanto de las tecnologías que hoy tenemos disponibles cuanto del tipo de tecnologías que decidamos desarrollar para el futuro” (Quintanilla, 2017: 9). La ciencia y la tecnología son los grandes propulsores de la sociedad y la cultura, por ello, nuestro principal objetivo es dilucidar el concepto de arte algorítmico ligado a los crecientes procesos de automatización que experimentamos en la actualidad, hoy la producción artística se encuentra conectada a los términos de automatización facilitados por los algoritmos y a los desarrollos en el área de la Inteligencia Artificial (IA), que comienza a adentrarse en los procesos y tareas cognitivas complejas donde la creatividad humana comienza a ser, si no reemplazada sí redefinida.
Poesía atravesada por la vida y por la piel
Authors: Abreu-Cornelio Agustin
Published: January 2024

João da Cruz e Sousa es un autor canónico de la literatura brasileña y su obra un testimonio de la lucha por la emancipación y reivindicación afrodescendiente de fines del siglo XIX. Aunque sus textos en prosa publicados en vida fueron mucho más numerosos que los escritos en verso, sus poemas en prosa han sido escasamente traducidos al español. Estas traducciones se proponen como dos pequeños pasos para enmendar ese vacío, mediante dos poemas del libro Evocações (1898).
Evaluación de planes de mejora continua en escuelas de la educación media superior
Authors: Tapia-Bernabé Irvin Rodolfo
Published: January 2024

Se muestra una metodología para evaluar la calidad de los planes de mejora continua (PMC) en escuelas del tipo medio superior. Para ello, se elaboró una rúbrica validada por juicio de expertos y Alpha de Crombach. Los resultados obtenidos muestran la distribución del nivel de calidad de los PMC, así como los errores más recurrentes durante el proceso de planificación.
Emociones, sentimientos y creencias de los docentes en el nivel medio superior al enfrentarse en el proceso de evaluación de sus alumnos.
Authors: Espinoza-Islas Verónica Marcela , Rubiales-Sánchez Fátima Sandra , Santana-Galindo Ana Lilia
Published: January 2024

Resumen

Analizar el proceso de evaluación, es trabajar con un objeto complejo que puede ser observado en diferentes dimensiones. Los niveles de análisis a considerar pueden ser macro o microsociales. En el nivel macro se tiene como objetivo mostrar la calidad de la educación nacional y se basa en pruebas estandarizadas; se tiene por ejemplo las políticas públicas encaminadas a mejorar la educación. En un nivel micro tenemos a las instituciones, docentes y alumnos; inmersos en la práctica de evaluación (véase, Fasce, 2006).

El objetivo de esta investigación es de carácter microsocial, ya que se analizará la parte afectiva a la que se enfrenta el docente durante el proceso de evaluación de los alumnos, se considerarán tres factores principales en este proceso de interrelación: emociones, sentimientos y creencias.
Analisis Pengaruh Diameter Lilitan dan Variasi Jumlah Lilitan Terhadap Efisiensi Generator Sinkron Magnet Permanen 24 Slot 16 Pole
Authors: Putra Reza Junius , Gusnita Novi
Published: January 2024

The need for electrical energy is a basic need that cannot be eliminated in the daily lives. With the increase in population, the need for electrical energy increases every year. Non-renewable energy has many examples, such as coal, oil, gas and so on. Wind energy is an alternative energy whose availability in nature. To convert wind energy into electrical energy, a Wind Power Plant is needed. In the conversion process using a generator. A generator that can be used is the Permanent Magnet Synchronous Generator 24 Slot 16 Pole (PMSG) which can produce magnetic flux and is suitable for use because with low rotation it can produce good efficiency to overcome areas with low wind speeds in Indonesia. To design and test through simulation with infolytica Magnet software based on the Finite Element Method. To increase efficiency in PMSG, this research analyze the effect of coil wire and the number of coils with coil wire diameters of 4 mm2, 6 mm2 and 8 mm2. For the number of coils starting from 25, 30 and 35 coils using a speed of 500 rpm and a load of 10 Ohms equalize all variations. Where the highest efficiency is 88.2%, the output power is 1609.4 Watt, the input power is 1842.0 Watts, the current is 12.49 Amperes and the voltage is 124.9 Volts, obtained on a wire area of 8 mm2 and a number 35 turns with an efficiency of 87.1%.

Keywords - PLTB, Lilitan, Generator, Efficiency, Energy
ACTIVITY-BASED COSTING: A PRACTICAL MODEL OF COST CALCULATION IN PSYCHIATRIC HOSPITALS
Authors: Kirzhetska Mariia S. , Kirzhetskyy Yuriy I. , Zelenko Natalia M. , Zelenko Vasyl A. , Klos Liliia Y. , Shkoliar Mariana V. , Gnylianska Lesia Y.
Published: January 2024

The aim: This paper is an analytical and descriptive study of the use of the Activity Based Costing (ABC) system in mental healthcare institutions for the allo¬cation of overhead costs of auxiliary units that provide non-medical services. The realistic estimates obtained using this costing system will help improve the allocation of resources, especially in the conditions of increased number of patients, and to control overhead costs, ensuring the reduction of non-productive expenses, increasing the efficiency and effectiveness of the mental health and psychosocial support institution.
Materials and methods: The study describes and uses ABC as a system and method for calculating inpatient care costs in 2022. The cost of medical services will be calculated as the sum of direct and overhead costs. Overhead costs into inpatient care consist of medical support units overhead costs and non-medical support units overhead costs. Overhead costs in non-medical support units were allocated to the cost of services within the cost centers:hospital departments that specialize in the treatment of specific mental health conditions. Expert opinion regarding the alignment of the cost allocation base with the factors identified for the allocation of each group of overhead costs in the mental health and psychosocial support facility was taken into account .
Results: Calculations showed the impracticality of using a single tariff for psychiatric care medical services for adults and children in inpatient conditions, since there are cost centers, namely, clinical departments of health care institutions, which consume a larger amount of resources. In particular, these are the departments providing the treatment of psychotic disorders caused by taking psychoactive substances, as well as schizophrenic, organic disorders, including symptomatic, mental disorders). Accordingly, the tariff for such medical services should be higher.
Conclusions: ABC is applicable in mental health care institutions and can help to efficiently cost processes, and thereby overcome a key challenge: to overesti¬mation or underestimation of costs into a medical services. Cost assignment through ABC generated more accurate cost estimates, which suggests that model of cost calculation ABC is more able to address complexity in mental health care institutions.
ABC should be gradually incorporated into an estimated approach to costing leads, to progressively bring reliable cost-accounting practices to mental health care institutions
ANALISIS KETERLAKSANAAN PROJEK “KELOLA SAMPAH PLASTIK UNTUK BUMI LESTARI” SEBAGAI PENGUATAN PROFIL PELAJAR PANCASILA PADA SISWA FASE B DI SDN PANGARANGAN 1
Authors: Sama’ Sama’ , Budiyono Fajar , Qasidah Sunfatun
Published: January 2024

Penelitian ini bertujuan untuk mendeskripsikan bagaimana keterlaksanaan projek kelola sampah plastik untuk bumi lestari sebagai penguatan profil pelajar pancasila serta bagaimana keterlaksanaan projek kelola sampah plastik untuk bumi lestari terhadap karakter cinta lingkungan siswa di Fase B di SDN Pangarangan I. Penelitian ini menggunakan metode penelitian kualitatif dengan pendekatan fenomenoligi yang dilakukan di SDN Pangarangan I kabupaten sumenep. Teknik pengumpulan data berupa wawancara, observasi dan dokumentasi. Data dianalisis dengan teknik interaktif meliputi reduksi data, penyajian data, dan penarikan kesimpulan/verifikasi. Hasil penelitian menunjukkan bahwa keterlakanaan projek kelola sampah plastik untuk bumi lestari berjalan dengan baik dan membawa pengaruh besar dalam membangun kesadaran diri siswa untuk mencintai lingkungan. Alur tahapan projek meliputi empat tahapan yaitu: pengenalan, kontekstualisasi, aksi kemudian refleksi. Melalui aksi P5 dapat menguatkan dimensi profil pelajar pancasila terutama dimensi beriman, bertakwa kepada Tuhan YME dan berakhlak mulia, bernalar kritis dan kreatif. Penguatan karakter profil pelajar pancasila dimensi beriman, bertakwa kepada Tuhan YME dan berakhlak mulia dilaksanakan melalui aksi B3 (Beramal, Berpahala, Beraksi). Kegiatan aksi dari dimensi kreatid memperoleh hasil karya berupa rak dinding, bunga plastik, kotak pensil, tabungan serta kemampuan siswa menentukan solusi permasalahan. Sedangkan pada dimensi bernalar kritis siswa mampu mengidentifikasi kode-kode plastik beserta kegunaannya
Wirklich neutral? Die Rechtsprechung des EuGH zu Kopftuchverboten am Arbeitsplatz auf dem Prüfstein der Grundrechte
Authors: Hertig Randall Maya
Published: January 2024

Inwiefern darf das Tragen religiöser Symbole und religiös konnotierter Kleidung am privaten Arbeitsplatz untersagt werden, ohne gegen das Diskriminierungsverbot zu verstossen? Der Beitrag geht dieser Frage nach, indem er die Rechtsprechung des EuGH aus einer schweizerischen Perspektive und mit rechtsvergleichenden Bezügen kritisch beleuchtet. Das Augenmerk liegt auf zwei Urteilen aus dem Jahr 2021 und 2022. Der Beitrag kommt zum Schluss, dass die beiden Entscheide dem Anliegen des Diskriminierungsschutzes besser Rechnung tragen als die vorhergehende Rechtsprechung. Die Bedingungen, welche der EuGH an die Zulässigkeit einer firmeninternen Politik der religiösen und weltanschaulichen Neutralität stellt, sind einer grundrechtsfreundlichen Auslegung zugänglich. Sie belässt den nationalen Gerichten einen beachtlichen Spielraum um sicherzustellen, dass das Diskriminierungsverbot und die Religionsfreiheit nicht einseitig wirtschaftlichen Interessen untergeordnet werden. Die Rechtsprechung internationaler Menschenrechtsorgane kann diesbezüglich wertvolle Impulse liefern.
In-vitro Investigation of Polyherbal Granules Potency on Inhibition of Alpha – Amylase Enzyme
Authors: - Ms. Priya Shukla , - Ms. Hinal Gangani , - Ms. Shweta Maury
Published: January 2024

Diabetes is an increasingly prevalent global disorder, affecting approximately 10% of the world's population. While there are various treatment options available in allopathic medicine, many of them come with undesirable side effects and can be financially burdensome. In response to these challenges, traditional plant-based approaches have emerged as promising antidiabetic treatments. In this research, we explore the potential of certain natural plants with alpha amylase inhibitory activity to mitigate the side effects associated with conventional diabetes treatments and provide more affordable and accessible alternatives for individuals managing this condition. In this study, we assess the impact of polyherbal granules and standard acarbose on α-amylase inhibition. The findings reveal that polyherbal granules demonstrate a significant inhibitory effect on alpha-amylase.
A Study on Consumer Preference Towards Health Insurance with Special Reference (Care Health Insurance)
Authors: - B.YOGESHWARAR , - Mr.T.CHANDRAMOHAN
Published: January 2024

The Insurance is a contract. Paying of the sum assured on the happening of the risk. Risk = un predicted stages in life. It not only insures the future financial operations but also to beat the inflation and make sure that one can appreciate its money value in future. The most challenging phase in the life stages are: To meet current and recurring expenses, to take care of children needs. Build Capital Assets like House or car and over all remain healthy and fine.
Impact of Online Audio Streaming Platforms on Youths: A Case Study of Vijayapura
Authors: - Philomina , - Tahmeena Nigar Sultana
Published: January 2024

In these days’ online audio streaming service also considered as one of the revenue generated platforms of streaming platforms. Audio Streaming services also includes subscription charges as well as video streaming platforms like Netflix and amazon prime video. Audio streaming platforms saves listeners time and it is also easy to access. Last few years’ audio streaming platform gaining too much of popularity because of it has many choices, maximum number of music collections and quality of music. So it’s absolutely draws to itself to youth. In India Spotify is the number one audio streaming application, Gaana, Wink Music, Jio Saavn, Apple music, Youtube music, Amazon Prime Music and many other audio streaming services gaining more popularity day by day. So, the main purpose of this study is to know how youths are engaged with audio streaming platforms and to examine how audio streaming services are stressbuster of youngsters. For this study descriptive research design was adopted and the primary data is collected through the survey method by using structured interview schedule. The responses were collected through the google form. The area of the study is Vijayapura District of Karnataka State. A total 160 respondents were selected. It is found from the study that youth are agree with most of the time on online audio streaming platform and they satisfied with listening music on audio streaming applications.
भारतीय किसान की लोमहर्षक त्रासदी- “गोदान”
Authors: - कुमारी ममता सिंह , - र्डॉ. ममता रानी
Published: January 2024

प्रेमचंद सम्पूर्ण मानव जाति का मंगल- कल्याण चाहने वाले मानवतावादी कलाकार
थे | साहित्य के सम्बंध में उनकी मान्यता थी- “अब साहित्य केवल मन-बहलाव
की चीज़ नहीं है | मनोरंजन के सिवाय उसका और भी कुछ उद्धेश्य है | अब वह
केवल नायक-नायिका के संयोग-वियोग की कहानी नहीं सुनाता, किंतु जीवन की
समस्याओं पर भी विचार करता और उन्हें हल करता है | अपनी इस मान्यता के
अनुसार उपन्यासों में विविध चरित्रों के चित्रण के माध्यम से प्रेमचंद ने जीवन की
समस्याओं पर विचार किया | प्रेमचंद उपन्यास को मानव-चरित्र का चित्र समझते
हैं | भारतीय किसान कैसा होता है, उसे कैसी- कैसी विपत्तियाँ सहन करनी पडती
हैं,यह बताने के लिए प्रेमचंद ने “गोदान” में होरी की कल्पना की है और उसके
माध्यम से भारतीय किसान की लोमहर्षक जीवन का वर्णन किया है |
Visualization and analysis of seepage below the dam foundation
Authors: Šreng Željko , Kaluđer Jelena , Šperac Marija , Miličević Silvia Iva
Published: January 2024

The analysis of water seepage below the model’s foundation of hydrotechnical object is conducted in the paper. A physical model of gravitational dam is made with the aim to visualize seepage through the ground below the dam. The model is made at the laboratory of the Faculty of Civil Engineering and Architecture in Osijek. The aim of the paper is to analyze the influence of the hydraulic gradient on seepage domain deformation, as well as to study the effect of different engineering measures on the decrease of hydraulic gradient. Four measurements were conducted which were mutually distinguished by the shape of the dam model, i.e. the foundation sheet. The first part of the paper is based on the assessment of measurement variants, i.e. engineering solutions used for the reduction of the seepage part of the buoyancy and seepage flow. The second part of the paper is dedicated to adoption of different models in the analysis of groundwater seepage below the object. Values related to seepage flow as well as buoyancy and pressure distribution below the foundation sheet were analyzed. Graphical, numerical, and approximate methods of analysis were used
Application of
ecological engineering in landfill remediation
Authors: Piljek Miletić Ivana , Stančić Zvjezdana , Fiket Željka
Published: January 2024

Ecological engineering is a new branch of engineering based on ecology that emerged in the 1960s from the growing need for more sustainable biological solutions to environmental problems. It is based on the design of natural ecosystems for the benefit of both nature and human society, and its techniques can be applied to a range of environmental problems, from the restoration of degraded ecosystems to the removal of pollutants. One of the major environmental problems worldwide is waste disposal in the form of landfills, with its various negative impacts on the environment, living beings and human health. Conventional landfill closure and remediation techniques have proven to be economically and energetically challenging and are not sufficiently effective in reducing leachate formation and removing pollutants. For this reason, this article presents several ecological engineering techniques that can be used in landfill remediation. Phytocapping is an alternative to conventional cover systems that uses plants to control and limit water infiltration into waste, leachate formation, stabilize landfills, control erosion, and reduce methane emissions. Phytoremediation is an environmentally friendly technology for soil remediation through natural processes, in two forms: phytoextraction and phytostabilization. Phytoextraction uses plants to extract and remove pollutants from waste and soil, while phytostabilization is used to immobilize pollutants in the root zone. Constructed wetlands, designed and constructed according to the principles of natural wetland ecosystems, can be used to clean leachate. Natural attenuation uses natural biological processes to mitigate pollution without taking specific action. All of these techniques are based on viable natural solutions that can reduce remediation costs and further maintenance of the landfill. Although they are increasingly being considered in developed countries, there are few examples of their application in landfill remediation in Croatia.
Irrigation water quality and criteria/standards in Croatia - contribution to the environment and industry
Authors: Nemčić-Jurec Jasna
Published: January 2024

The water quality used for irrigation should meet the prescribed criteria. The most commonly determined indicators are electrical conductivity (EC), total dissolved salts (TDS), residual sodium carbonate (RSC) and sodium absorption ratio (SAR). Water can also contain harmful substances, regardless of whether irrigation is carried out from surface water or groundwater. The origin of the pollution can be waste, untreated wastewater or saltwater intrusion. The use of poor water quality can cause soil problems such as alkalinity, salinity, increased sodium concentration, toxicity, etc. In Koprivnica- Križevci county (KKŽ) and throughout Croatia, irrigation is currently poorly represented in agriculture. Given the climate change and the trends of very dry and hot seasons, the implementation of irrigation is of increasing importance. According to the results of determining the groundwater quality for irrigation in KKŽ, the values of the indicators are satisfactory (EC = <0.7 dS/m; TDS = <450 mg/l; RSC = <1.25 meq/l; SAR = <3.0 meq/l) for use in agriculture. However, since there are no standards and criteria in Croatian regulations that would define water quality, the results are compared with European/world standards. Water quality testing and the adoption of standards/criteria in Croatia could contribute to the future development of agriculture in increasingly unfavorable climatic conditions and prevent environmental pollution. This would ensure more efficient cultivation of plants, which also contributes to production in our own food industry.
Bioschemas Resource Index for Chem and Plants
Authors: Arend Daniel , Del Conte Alessio , Feser Manuel , Gadiya Yojana , Gaignard Alban , Castro Leyla Jael , Mičetić Ivan , Moretti Sebastien , Neumann Steffen , Rayya Noura , Tsueng Ginger , Willighagen Egon , Wittig Ulrike
Published: January 2024

As part of the BioHackathon Europe 2023, we here report on the progress of the hacking team preparing a resource index and knowledge graph based on the JSON-LD Bioschemas markup from several resources in the life- and natural sciences, predominantly from the fields of plant- and (bio)chemistry research. This preliminary analysis will allow us to better understand how Bioschemas markup is currently used in these two communities, so we can take actions to improve guidelines and validation on the Bioschemas markup and the data providers side. The lessons learnt will be useful for other communities as well. The ultimate goal is facilitating and improving interoperability across resources.
The Impact of Exclusive Breastfeeding on the Occurrence of Diarrhea in Babies between the Ages of 6 and 12 Months in Purwakarta Regency, Indonesia
Authors: Febriana Rositta
Published: January 2024

Diarrhea is a prevalent infectious ailment among babies and young children. Exclusive breastfeeding decreases the occurrence of diarrhea. The objective of this study is to assess the efficacy of exclusive breastfeeding in reducing the occurrence of diarrhea among babies aged 6–12 months in Purwakarta Regency, Indonesia. This study employs an observational design utilizing a cross-sectional method. The research sample consisted of babies aged 6–12 months residing in Purwakarta Regency, Indonesia. We gathered data by utilizing a questionnaire. We used the chi-square test to analyze the data. The study's findings indicated a notable correlation between exclusive breastfeeding and the occurrence of diarrhea (p = 0.001). Babies who receive exclusive breast milk have a significantly reduced risk, 13.661 times lower, of developing diarrhea compared to babies who do not receive exclusive breast milk. In conclusion, exclusive breastfeeding is efficacious in avoiding diarrhea among babies aged 6–12 months.
Paradigm of immune dysregulation in coronavirus disease-2019 infection
Authors: Sahoo Om Saswat , Pethusamy Karthikeyan , Nayek Arnab , Minocha Rashmi , Dhar Ruby , Karmakar Subhradip
Published: January 2024

The coronavirus disease 2019 (COVID-19) pandemic cost 7–8 million deaths worldwide, creating an unprecedented health and economic crisis. Affecting 700 million people globally, the magnitude of this pandemic is far from anything that humanity has encountered in recent times. A detailed investigation revealed that more than the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, the hyperactive immune system mediated injury as the real cause of mortality. Cytokine storm following viral infection leads to the surge of proinflammatory cytokines resulting in acute respiratory distress syndrome (ARDS) and lung injury. Anti-inflammatory intervention with anti-interleukin-6 (anti-IL-6) receptor monoclonal antibodies (mAbs; e.g., sarilumab and tocilizumab) and anti-IL-6 mAbs (i.e., siltuximab) and/or steroid-based approach leads to substantial protection and prevent death thereby implying the role of inflammation in COVID-19. In this review, the authors have summarized the dysregulated immune system in COVID-19 infection, investigating in detail the virus-host immune cross talks and presenting the possibilities of therapeutic intervention.
The Development Strategy of Waqf Insurance Benefits and Investment Benefits in Islamic Life Insurance PT. Takaful Medan Branch
Authors: Batubara Chuzaimah , Pujiyanti Lilis , Syahriza Rahmi
Published: January 2024

This study aims to evaluate the strategy of developing waqf benefits in Sharia insurance and investment benefits in Sharia life insurance at PT Takaful Keluarga Medan, and to formulate strategic recommendations based on SWOT and QSPM analysis. The research method used is descriptive qualitative by applying SWOT and QSPM analysis. The results of the SWOT analysis show that the strategic position of PT Takaful Keluarga Medan is in quadrant 1 (positive strategy), between strengths and opportunities. Strategic recommendations include consistent development of Sharia products, increasing public trust through excellent service, platform diversification for better accessibility, training and socialization about waqf benefits, and improving the quality of human resources. QSPM analysis indicates that the prioritized development strategy is to leverage the Sharia insurance brand and enhance customer trust through digital platforms, increase the number of marketers, improve product quality, workforce understanding, and collaboration with Islamic institutions. The researchers hope that these findings can serve as considerations for students in selecting alternative strategies, while for future researchers, it is hoped that they can analyze other factors and variables not explored in this study.
Analisis Kapasitas Ruang Parkir Sepeda Motor Pada Pelabuhan Ipi Ende
Authors: Gare Mansuetus , Kota Ireneus , Luis Andreas
Published: January 2024

Parking is a special place for vehicles to stop for a while. Problems with the area of parking lots and the number of vehicles often occur in developing cities in Indonesia today. This has also happened in the city of Ende, especially in the Ipi harbor motorbike parking area which was affected by the increase in the number of residents and the number of vehicle activities. In order to find a safe parking space, it is necessary to do some research. This study aims to determine the value of parking characteristics and capacity (service capability) of motorbike parking spaces in Ipi Ende port. The method used in this study was direct observation (observation) which was carried out for 3 days. The data taken is in the form of parking volume, parking accumulation and parking duration. The data was then processed using "Guidelines for planning and parking facilities by the Directorate General of Land Transportation" (1998). The results of this study obtained parking volume = 126 vehicles, accumulation = 79 vehicles, average parking duration = 1.44 hours/vehicle, rate of change an = 1 vehicle/SRP/hour and parking index value = 94%. This shows that this value is close to the current parking service capacity threshold. As a suggestion, it is necessary to provide parking officers so that the provision of parking is more effective.
Nicotinamide adenine dinucleotide phosphate oxidase in pancreatic diseases: Mechanisms and future perspectives
Authors: Bi Ya-Wei , Li Long-Song , Ru Nan , Zhang Bo , Lei Xiao
Published: January 2024

Pancreatitis and pancreatic cancer (PC) stand as the most worrisome ailments affecting the pancreas. Researchers have dedicated efforts to unraveling the mechanisms underlying these diseases, yet their true nature continues to elude their grasp. Within this realm, oxidative stress is often believed to play a causal and contributory role in the development of pancreatitis and PC. Excessive accumulation of reactive oxygen species (ROS) can cause oxidative stress, and the key enzyme responsible for inducing ROS production in cells is nicotinamide adenine dinucleotide phosphate hydrogen oxides (NOX). NOX contribute to pancreatic fibrosis and inflammation by generating ROS that injure acinar cells, activate pancreatic stellate cells, and mediate macrophage polarization. Excessive ROS production occurs during malignant transformation and pancreatic carcinogenesis, creating an oxidative microenvironment that can cause abnormal apoptosis, epithelial to mesenchymal transition and genomic instability. Therefore, understanding the role of NOX in pancreatic diseases contributes to a more in-depth exploration of the exact pathogenesis of these diseases. In this review, we aim to summarize the potential roles of NOX and its mechanism in pancreatic disorders, aiming to provide novel insights into understanding the mechanisms underlying these diseases.
Development and validation of a prediction model for early screening of people at high risk for colorectal cancer
Authors: Xu Ling-Li , Lin Yi , Han Li-Yuan , Wang Yue , Li Jian-Jiong , Dai Xiao-Yu
Published: January 2024

BACKGROUND

Colorectal cancer (CRC) is a serious threat worldwide. Although early screening is suggested to be the most effective method to prevent and control CRC, the current situation of early screening for CRC is still not optimistic. In China, the incidence of CRC in the Yangtze River Delta region is increasing dramatically, but few studies have been conducted. Therefore, it is necessary to develop a simple and efficient early screening model for CRC.

AIM

To develop and validate an early-screening nomogram model to identify individuals at high risk of CRC.

METHODS

Data of 64448 participants obtained from Ningbo Hospital, China between 2014 and 2017 were retrospectively analyzed. The cohort comprised 64448 individuals, of which, 530 were excluded due to missing or incorrect data. Of 63918, 7607 (11.9%) individuals were considered to be high risk for CRC, and 56311 (88.1%) were not. The participants were randomly allocated to a training set (44743) or validation set (19175). The discriminatory ability, predictive accuracy, and clinical utility of the model were evaluated by constructing and analyzing receiver operating characteristic (ROC) curves and calibration curves and by decision curve analysis. Finally, the model was validated internally using a bootstrap resampling technique.

RESULTS

Seven variables, including demographic, lifestyle, and family history information, were examined. Multifactorial logistic regression analysis revealed that age [odds ratio (OR): 1.03, 95% confidence interval (CI): 1.02-1.03, P < 0.001], body mass index (BMI) (OR: 1.07, 95%CI: 1.06-1.08, P < 0.001), waist circumference (WC) (OR: 1.03, 95%CI: 1.02-1.03 P < 0.001), lifestyle (OR: 0.45, 95%CI: 0.42-0.48, P < 0.001), and family history (OR: 4.28, 95%CI: 4.04-4.54, P < 0.001) were the most significant predictors of high-risk CRC. Healthy lifestyle was a protective factor, whereas family history was the most significant risk factor. The area under the curve was 0.734 (95%CI: 0.723-0.745) for the final validation set ROC curve and 0.735 (95%CI: 0.728-0.742) for the training set ROC curve. The calibration curve demonstrated a high correlation between the CRC high-risk population predicted by the nomogram model and the actual CRC high-risk population.

CONCLUSION

The early-screening nomogram model for CRC prediction in high-risk populations developed in this study based on age, BMI, WC, lifestyle, and family history exhibited high accuracy.
Recombinant adeno-associated virus 8-mediated inhibition of microRNA let-7a ameliorates sclerosing cholangitis in a clinically relevant mouse model
Authors: Hua Hui , Zhao Qian-Qian , Kalagbor Miriam Nkesichi , Yu Guo-Zhi , Liu Man , Bian Zheng-Rui , Zhang Bei-Bei , Yu Qian , Xu Yin-Hai , Tang Ren-Xian , Zheng Kui-Yang , Yan Chao
Published: January 2024

BACKGROUND

Primary sclerosing cholangitis (PSC) is characterized by chronic inflammation and it predisposes to cholangiocarcinoma due to lack of effective treatment options. Recombinant adeno-associated virus (rAAV) provides a promising platform for gene therapy on such kinds of diseases. A microRNA (miRNA) let-7a has been reported to be associated with the progress of PSC but the potential therapeutic implication of inhibition of let-7a on PSC has not been evaluated.

AIM

To investigate the therapeutic effects of inhibition of a miRNA let-7a transferred by recombinant adeno-associated virus 8 (rAAV8) on a xenobiotic-induced mouse model of sclerosing cholangitis.

METHODS

A xenobiotic-induced mouse model of sclerosing cholangitis was induced by 0.1% 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine (DDC) feeding for 2 wk or 6 wk. A single dose of rAAV8-mediated anti-let-7a-5p sponges or scramble control was injected in vivo into mice onset of DDC feeding. Upon sacrifice, the liver and the serum were collected from each mouse. The hepatobiliary injuries, hepatic inflammation and fibrosis were evaluated. The targets of let-7a-5p and downstream molecule NF-κB were detected using Western blot.

RESULTS

rAAV8-mediated anti-let-7a-5p sponges can depress the expression of let-7a-5p in mice after DDC feeding for 2 wk or 6 wk. The reduced expression of let-7a-5p can alleviate hepato-biliary injuries indicated by serum markers, and prevent the proliferation of cholangiocytes and biliary fibrosis. Furthermore, inhibition of let-7a mediated by rAAV8 can increase the expression of potential target molecules such as suppressor of cytokine signaling 1 and Dectin1, which consequently inhibit of NF-κB-mediated hepatic inflammation.

CONCLUSION

Our study demonstrates that a rAAV8 vector designed for liver-specific inhibition of let-7a-5p can potently ameliorate symptoms in a xenobiotic-induced mouse model of sclerosing cholangitis, which provides a possible clinical translation of PSC of human.
Bile acids inhibit ferroptosis sensitivity through activating farnesoid X receptor in gastric cancer cells
Authors: Liu Chu-Xuan , Gao Ying , Xu Xiu-Fang , Jin Xin , Zhang Yun , Xu Qian , Ding Huan-Xin , Li Bing-Jun , Du Fang-Ke , Li Lin-Chuan , Zhong Ming-Wei , Zhu Jian-Kang , Zhang Guang-Yong
Published: January 2024

BACKGROUND

Gastric cancer (GC) is associated with high mortality rates. Bile acids (BAs) reflux is a well-known risk factor for GC, but the specific mechanism remains unclear. During GC development in both humans and animals, BAs serve as signaling molecules that induce metabolic reprogramming. This confers additional cancer phenotypes, including ferroptosis sensitivity. Ferroptosis is a novel mode of cell death characterized by lipid peroxidation that contributes universally to malignant progression. However, it is not fully defined if BAs can influence GC progression by modulating ferroptosis.

AIM

To reveal the mechanism of BAs regulation in ferroptosis of GC cells.

METHODS

In this study, we treated GC cells with various stimuli and evaluated the effect of BAs on the sensitivity to ferroptosis. We used gain and loss of function assays to examine the impacts of farnesoid X receptor (FXR) and BTB and CNC homology 1 (BACH1) overexpression and knockdown to obtain further insights into the molecular mechanism involved.

RESULTS

Our data suggested that BAs could reverse erastin-induced ferroptosis in GC cells. This effect correlated with increased glutathione (GSH) concentrations, a reduced GSH to oxidized GSH ratio, and higher GSH peroxidase 4 (GPX4) expression levels. Subsequently, we confirmed that BAs exerted these effects by activating FXR, which markedly increased the expression of GSH synthetase and GPX4. Notably, BACH1 was detected as an essential intermediate molecule in the promotion of GSH synthesis by BAs and FXR. Finally, our results suggested that FXR could significantly promote GC cell proliferation, which may be closely related to its anti-ferroptosis effect.

CONCLUSION

This study revealed for the first time that BAs could inhibit ferroptosis sensitivity through the FXR-BACH1-GSH-GPX4 axis in GC cells. This work provided new insights into the mechanism associated with BA-mediated promotion of GC and may help identify potential therapeutic targets for GC patients with BAs reflux.
Impact of Parental History of Hypertension on Heart Rate by Treadmill
Authors: Kunipuri Sarala, Reddipogu Pavani, Akumalla Krishnaveni
Published: January 2024

The heart rate response to exercise is another determinant of the healthy cardiovascular system. Increased heart rate has been shown to be predictive of mortality and morbidity. A total of 100 subjects with parental history of hypertension were divided into two groups during pre exercise and post exercise period by tread mill. There was a significant decrease in heart rate after training. Heart rate variation has been shown to be predictive of mortality and morbidity in subjects with parental history of hypertension.
Glycated Haemoglobin and its Association with Lipid Profile in Type 2 Diabetes Mellitus
Authors: Santosh Palekar, Umesh Balgi, Sandhya M
Published: January 2024

Background

Patients with type 2 diabetes have an increased prevalence of lipid abnormalities, contributing to their high risk of cardiovascular diseases (CVD)1. Glycated hemoglobin (HbA1c) is the indicator of glycemic status over long term. This study is an attempt to evaluate the diagnostic value of HbA1c in predicting diabetic dislipidemia. Method: Venous blood was collected from 100 type 2 diabetic patients age 35–75 years, 50 males and 50 females attending the Diabetic OPD, Civil hospital Gulbarga were enrolled in the study. Investigations like fasting and post prandial blood sugar, HbA1c and lipid profile (Cholesterol, Triglycerides, HDL, LDL & VLDL). Both males and females patients with worse glycemic control (HbA1c > 9%) had significantly high cholesterol and LDL levels. Result: HbA1c showed direct and significant correlation with cholesterol, triglicerides and LDL cholesterol, and reverse correlation with HDL cholesterol..
Etiological Profile of Azoospermic Patients attending Male Biological Reproductive Unit of Mahatma Gandhi Institute of Medical Sciences, Sewagram (Maharashtra), India
Authors: Santosh Balgote, Anil Chaudari
Published: January 2024

Introduction

The term “Azoospermia” is defined as the complete absence of sperm in the ejaculate, is identified in approximately 1% of all men and in 10 to 15% of infertile males. The semen analysis should be performed according to the 2010 WHO guidelines, and at least two semen samples obtained more than two weeks apart should be examined.

Material and Method

The present cross sectional hospital based study was conducted in reproductive biology unit of department of physiology, MGIMS, Sewagram (M.S.) India, during study period September 2011 to August 2013. Subjects belonged to age group of 21 to 45 year. The semen samples were obtained from male partner (referred from gynecology department) of infertile couples attending the reproductive biology unit. 90 freshly diagnosed patients were selected for study. The patients were interviewed about their case histories, their reproductive problems, and their family background. All WHO Guidelines was strictly fallowed so that identity of subject should not be revealed. In subject with absence of spermatozoa in semen three consecutive semen analysis were performed at an interval of one month each.

Observations

The prevalence rate of Azoospermic patient was found to be 19.90%. We observed that out of 90 azoospermic patients, 40% of patient was of Obstructive Azoospermia and remaining 60% was of Non-Obstructive Azoospermia. We found that the most common aetiology of obstruction was Epididymal cyst (23 patients), contributing 63.89% to its aetiology. Most common aetiology of Non-obstruction was Varicocele (23 patients) contributing 42.59%.

Conclusions

The current study highlighted the etiological spectrum of azoospermia cases.
Introduction of Concept Mapping as an Innovative Tool to Enhance Learning Outcome in the Medical Students
Authors: Veenodini Warhade, Pratibha Mehta
Published: January 2024

Introduction

In today's multifaceted & challenging context of medical education, students are unable to organise, integrate information to the medical problems, so a need to fill this gap is strongly felt. The purpose of this study was to evaluate the effectiveness of Concept Mapping (CM) over the traditional method of teaching & learning.

Aims & Objectives

To compare learning by traditional lecture with lecture using CM. To foster meaningful learning using CM & boosting the relevance of topic. To obtain feedback & reflection for CM based learning.

Materials & Method

Total 112 students were taken for the study. They were divided randomly in two groups. For group-A, lecture on Systemic lupus erythematous was taken by traditional method of teaching. For group-B lecture was taken by using concept mapping of same topic. Post-test (10 Marks MCQs) was taken from both groups & comparing was done. Cross over study was conducted for ethical purpose. Reflection & feedback was taken from students about CM.

Result

The result of post-test shows significant (P<0.01) rise in marks in Group B (CM) as compare to Group A (Traditional method), suggesting CM as a potential tool for better understanding & easy recall. Regarding reflection of students about concept method over traditional lecture method it was observed that more than 90% students said that it is simpler, easy, smart, concise, efficient and effective method of learning.

Conclusion

Students found it very interesting & effective tool for learning. Students also feel that this method will be helpful for revision before the sessional & professional examination.
A Comparative Study of Sleep Quality and Heart Rate Variability Index in Shifts and Non-Shift Working Population of Bengaluru
Authors: Sunkari Davana
Published: January 2024

Background

Urban working population lead a busy stressful life with poor sleep quality and health. The present study targets working population including both Shift and Non-Shift (9am-6pm) workers to analyse their sleep quality and heart rate variability and to evaluate for association between them.

Objectives

This study aims to analyse Sleep quality and Heart Rate Variability (HRV) in working population of Bengaluru and to evaluate for association between these two parameters in the study group.

Materials and Method

50 professional workers in the age group of 20-35yrs were subjectively analysed for their quality of sleep using Pittsburgh Sleep Quality Index (PSQI). HRV was recorded with finger photoplethysmograph using infrared light, placed on left index finger of subjects. The analog signals of the device were digitized and reported through Kubios HRV software.

Results

Sleep quality and HRV indices were found to be better in people working from 9am-6pm shifts (Non-Shift workers) compared to people working in other shifts. Significant correlation between Sleep quality and HRV indices was observed.

Conclusion

Non-shift workers have better Sleep quality and HRV indices compared to Shift workers in Bengaluru city.
Study of Changes in QTc Interval with Menstrual Cycle in Young Adult Female Basket Ball Players
Authors: Priya C. Rao, Chethan H.A.
Published: January 2024

Objective

Study of changes in QTc interval with menstrual cycle in young adult female basketball players.

Method

Healthy young female adults in the age group of 18–22 years physicaly fit subjects were selected among general population. Sample size was 40. Parameters of ECG, QT interval, RR interval, QTc Interval were recorded during different phases of menstrual cycle. Mean and Standard deviation was calculated.

Results

There was significant rise in QTc Interval recorded during menstrual phase

Conclusion

Women are at risk of developing ventricular arrhythmias during menstrual phase as compared to Proliferative and Secretory phase.