bluuebunny/crossref_metadata_2025 huggingface dataset:
FATORES DE RISCO CARDIOVASCULAR ASSOCIADOS À DINAPENIA EM IDOSOS
Authors: Santana Pabline dos Santos , Dos Santos Lucas , Leal Neto João de Souza , Caires Sabrina da Silva , Souza Adriano Almeida , Casotti Cezar Augusto
Published: May 2023

O estudo teve como objetivo identificar os fatores de risco cardiovascular associados à dinapenia em idosos. Trata-se de uma pesquisa epidemiológica, transversal, realizada com idosos de Aiquara-BA. Os fatores de risco cardiovascular avaliados foram: sexo, grupo etário, etnia, nível de atividade física, circunferência da cintura, relação cintura-quadril, índice de adiposidade corporal, nível de glicemia sanguínea e perfil lipídico (triglicerídeos; colesterol total; High-Density Lipoprotein cholesterol – HDL-c e Low-Density Lipoprotein cholesterol – LDL-c). O diagnóstico da dinapenia foi realizado, estratificado por sexo, a partir dos seguintes valores de força de preensão manual: 24,87 kgf (homens) e 18,25 kgf (mulheres). A análise associativa foi verificada por meio do teste qui-quadrado de Person. Contudo, para as frequências esperadas menores que cinco (n < 5) foi utilizado o teste Exato de Fisher. O nível de significância adotado em todas as análises foi de 5,0% (p ≤ 0,05). Participaram do estudo 109 idosos (55,0% mulheres), com média de idade de 71,0 ± 7,4. O percentual de idosos hipertensos foi de 45,0%, fumantes ou ex-fumantes 65,0%, insuficientemente ativos 17,1%, com elevada circunferência da cintura 46,8%, relação cintura-quadril elevada 67,0%, obesos 44,0%, com diabetes mellitus 20,4%, hipercolesterolemia 59,3%, com baixo HDL-c 36,5% e LDL-c elevado 44,0%. A prevalência da dinapenia foi de 24,8% (mulheres, 25,0% e homens, 24,5%). Ademais, averiguou-se maior prevalência de dinapenia nos longevos (50,0%) e nos insuficientemente ativos (55,6%) (p < 0,05). Conclui-se que, entre os idosos residentes em Aiquara-BA, o nível de atividade física insuficiente e a idade avançada estiveram associados à dinapenia.
Prostate Cancer: Germline Mutations in BRCA1 and BRCA2
Authors: Umarane Pankaja , Ghagane Shridhar C , Nerli Rajendra
Published: May 2023

Genetic alterations are one of the important known risk factors of Prostate cancer. The family predisposition of breast and ovarian cancers may cause the lethal progression of familial prostate cancer in some men. The Association of germline mutations in BRCA1 and BRCA2 genes can cause breast cancer in almost 35% of women and 9% of men. Carriers of these pathogenic variants have a higher risk of causing prostate cancer. This study focused on the analysis of mutations causing prostate cancer around the world, associated with breast cancer susceptibility genes.
Meta-analysis on the Diagnostic Performance of p16/Ki-67 Dual Immunostaining for Cervical Cancer Screening
Authors: Okoturo Eyituoyo , Rabiu Kabiru
Published: May 2023

Background: This article discusses cervical cancer and its higher incidence in LMIC compared to HIC due to limited resources and poor prevention strategies. It is preventable through early detection of persistent high-risk HPV infection, which is a critical promoter. Screening methods have evolved from pap smear cytology to HPV-DNA testing and currently to co-testing, but these methods still result in false positives and high colposcopy referrals. p16/Ki-67 dual immunostaining was proposed as a biomarker for cervical cancer triage due to its ability to detect HPV-mediated neoplastic transformation. The aim of the study was to evaluate the sensitivity and specificity of this dual staining method through a review and meta-analysis of published data.Material and Methods: The search was based on PRISMA guidelines using specific MeSH terms and keywords. The search was limited to publications that compared p16/Ki-67 dual immunostaining to Pap cytology and/or high-risk HPV-DNA and included colposcopy biopsy results as the diagnostic standard. The study focused on diagnostic performance outcomes such as sensitivity, specificity, and diagnostic odds ratio. To be eligible for meta-analysis, a publication must report the diagnostic performance at predicting CIN2+. Results: A total of 24 studies were included in the review and 21,450 samples were used for dual immunostaining. The results showed that dual immunostaining was significantly more sensitive than pap cytology (75.9% compared to 71.1%) and had a higher specificity (79.7% compared to 64.3% for pap cytology and 48.9% for HPV-DNA). A meta-analysis showed that dual immunostaining had a higher pooled diagnostic odds-ratio compared to pap cytology and HPV-DNA, indicating a better test power. Conclusions: The study suggested that dual immunostaining is a better approach for detecting HPV-induced cervical cancer compared to traditional screening methods. The authors suggest that despite its reduced sensitivity, dual immunostaining should be considered as a promising alternative, especially in large-scale testing.
A Qualitative Study to Explore Patient’s experiences on Chemotherapy-induced Nausea and Vomiting: Focusing Impact on Daily Life
Authors: Gour Sushil , Kore Anamika , Das Abhijit , Dane Jyoti , Maurya Rajesh Kumar
Published: May 2023

Background: This study aimed to explore the experience of cancer patients about chemotherapy-induced nausea and vomiting and its effect on patients’ daily life. Methods: A descriptive qualitative study was conducted on cancer patients who experience nausea and vomiting due to chemotherapy. Semi-structured interview guide consisting of eight questions was used as a study tool and thematic analysis was done using QDA Miner lite software.Results: Twenty-five participants were included in the final analysis. The median age of the participants was 53 (IQR-15) years and most of the patients were Hindu. All the patients were newly diagnosed. Approximately 80% of patients had received three cycles of chemotherapy by the time of their interviews. Adriamycin, Cyclophosphamide (AC), Docetaxel (T), Paclitaxel and Carboplatin (P+C) were the chemotherapy drugs administered. Our findings suggest that chemotherapy-induced nausea and vomiting has affected many aspects of patient’s lives, especially those related to eating, physical, emotional, and social functioning, but the degree of impact was unique to each patient. Conclusion: The individual experiences of nausea and vomiting during chemotherapy treatment may have a profound effect on treatment compliance and future outcomes. Specific assessment and innovative approaches for its subsequent management are highly needed while considering the complexity of these symptoms.
Neoadjuvant Systemic Therapy for Locally Advanced Breast Cancer in St. Luke’s Medical Center: 10-Year Local Experience and Response Rates
Authors: Cruz-Ordinario Mel Valerie B. , Malesido May Rose A. , Sabando May N. , Gorospe Agnes E. , Dy Carlos
Published: May 2023

Background: Neoadjuvant therapy has given important prognostic and predictive information based on pathologic response as seen on studies showing that pathologic complete response (pCR) is associated with favorable disease-free and overall survival in some molecular subtypes. The main objective is to determine the pCR rate among patients with locally advanced breast cancer (LABC) in our institution. Method: A total of 259 patients with LABC who received neoadjuvant therapy and underwent definitive surgery at St. Luke’s Medical Center Quezon City from 2007 to 2017 were retrospectively analyzed through chart review. Results: Patients’ median age at diagnosis was 51 years old. 57% were premenopausal and 42% were postmenopausal. The most common histology was Invasive Ductal at 92%. The most common subtype was Luminal/HER2 negative (52%). Majority of the patients have Stage III disease. The most common chemotherapy regimen used was sequential Anthracycline and Taxane (AC/EC/FEC then Taxane with or without Trastuzumab and Docetaxel with or without Trastuzumab followed by FEC) at 31%, Anthracycline-based (Doxorubicin or Epirubicin with Cyclophosphamide/5FU -EC/ AC/FAC) at 28%, and concurrent Anthracycline-based and Taxane (TAC/AT/ET) at 27%. Of the 95 patients with Her 2 positive disease, 21 (22%) received anti-Her2 blockade as part of their neoadjuvant regimen. The pCR, defined as absence of invasive residual cancer in the breast and axillary lymph nodes, with or without ductal carcinoma-in-situ (DCIS) was seen in 46 patients (18%). Among the patients who achieved pCR, the most common subtype is Luminal/HER2 negative at 17% and the most common regimen used was Docetaxel followed by FEC (5FU+EC) at39%. Conclusion: Among 259 patients, pCR is achieved in 18% of patients using standard chemotherapy. This study shows that the most common neoadjuvant regimen used was sequential Anthracycline and Taxane and most common subtype is Luminal/Her negative.
Promoter Hypermethylation of ATG16L2, TFAP2A, EBF2, Calcitonin, ABL1 Kinase Domain T315I Mutation Association with Imatinib Therapy Resistance and Median Survival in CML Patients of North-East India
Authors: Sarma Anupam , Kataki Amal Chandra , Rai Avdhesh Kumar , Hazarika Munlima , Roy Partha Sarathi , Kalita Manoj , Deka Manab , Chattopadhyay Indranil
Published: May 2023

Background and Objectives: Chronic myeloid leukemia (CML) initiation and progression is regulated by epigenetic and genetic alterations. Imatinib therapy resistance in CML patients is important clinical issue. To understand association of kinase domain mutation and promoter hypermethylation of genes with imatinib therapy resistance hold significance in CML patients of North-East India. This study is a hospital based cross sectional study. Methods: A total of Sixty three (n=63) CML patients undergone imatinib mesylate were enrolled for the study. ABL kinase domain T315I mutation was analyzed by Allele specific- PCR (AS-PCR) and confirmed by sequencing. Promoter hypermethylation was analyzed by Methylation specific PCR (MS-PCR). The Chi square test and Fisher exact test used in SPSS ver19. Results: Tyrosine Kinase domain mutation T315I was found in 30.1% (19/63). The promoter hypermethylation of Calcitonin, ATG16L2, TFAP2A, EBF2 gene was detected in 42.9% (n=27), 28.6% (n=18), 38.1% (n=24), 27% (n= 17) CML patients respectively. Median relapse free survival was 21 months and statistically significant for CML patients without T315I mutation compared to patients with T315I mutation who has 12 months median relapse free survival (p=0.005). Median survival was 19 months for patients without EBF2 promoter hypermethylation and also statistically significant compared to CML patients with promoter hypermethylation (12 months) (p=0.026). Interpretation and Conclusions: We conclude that among imatinib resistant CML patients of North- East India harbouring T315I mutation of ABL1 Kinase domain and promoter hypermethylation of EBF2 gene have significantly lower median relapse free survival.
Comparative Analysis of Dosimetry and Treatment Outcomes of Two Different Dose Fractionation Schedules of HDR Brachytherapy in Carcinoma Cervix Amid Covid-19 Pandemic
Authors: Meena Chetna , Saini Naresh Kumar , Mehta Harsha N , Gothwal Ravinder Singh , Dadheech Apoorva , Jain Sandeep
Published: May 2023

Background: Cervical carcinoma is the fourth most common cancer and leading cause of cancer related deaths in women worldwide. Brachytherapy is an important part in the treatment of cervical cancer. Delivering HDR Intracavitary Brachytherapy in the Covid-19 era is challenging. Objective: To compare the dosimetry and treatment outcomes between two fractionation schedules of 9Gy in 2 fractions v/s 7Gy in 3 fractions of high dose rate Brachytherapy in patients with locally advanced carcinoma cervix. Methods: A randomized observational study was carried out on 80 histopathologically proven squamous cell carcinoma patients of cervix. All patients were treated with EBRT 50Gy in 25 fractions over a period of 5 weeks (2Gy/#) with concurrent weekly cisplatin 30mg/m2. After assessing fitness for brachytherapy, patients in the study arm received HDR intracavitary brachytherapy in 9Gy for 2 fractions v/s 7Gy for 3 fractions in the control arm. Results: The median time of follow-up was 14 months for the study (range 7 – 20 months). Local control rate was 89.75% for study arm and 92.30% for control arm. One year disease free survival in the study arm was 76.92% as compared to 74.35% in the control arm. Median disease-free survival was better in the study arm (14 months v/s 12 months) with a trend of significant benefit. Rectal and bladder toxicities were comparable in both the arms. Median dose to ICRU bladder and rectal point, and EQD2 dose in both arms were not found to be statistically significant. Conclusion: Both the regimes were found to be safe. Disease response and toxicities were also similar in both the arms. There was a better patient compliance with 9Gy for 2 fractions schedule in view of lesser number of fractions resulting in less hospital visit in the Covid-19 pandemic.
PERAN CASE MANAGER DALAM PERMASALAHAN ORANG DENGAN HIV/AIDS
Authors: Faijah Anisa Safaatul , Sulastri Sri
Published: May 2023

Hidup dengan virus yang mematikan sperti HIV tidak hanya berhenti pada penderitaan fisik para penyitasnya, mereka juga harus menjalani kehidupan dengan terstigmatisasi. case manager bertugas untuk melakukan advokasi dan mempersiapkan lingkungan klien agar dapat bertemu titik “adapted” atau cocok dengan kebutuhan para penyitas HIV. Melalui artikel ini, penulis mencoba menggambarkan mengapa kompleksitas pemberian layanan perlu diberikan kepada orang dengan HIV/AIDS. Tulisan ini akan melihat apa saja yang harus dimiliki oleh seorang case manager saat bekerja dengan orang dengan HIV/AIDS, serta bagaimana perannya saat melakukan manajemen kasus. Penyusunan artikel ini menggunakan pendekatan deskriptif kualitatif dengan menggambarkan kondisi dari tema yang diangkat sebagai variabel yang diteliti. Artikel ini juga disusun menggunakan studi kepustakaan yang didapatkan secara online melalui pencarian buku dan artikel jurnal dengan melakukan pembatasan pencarian menggunakan kata kunci yang relevan dengan tema artikel ini. Mengacu pada studi kasus yang dilakukan oleh Barney et. al. pada permasalahan orang dengan HIV/AIDS di pedesaan di Alaska, dalam menjalankan perannya bekerja dengan orang dengan HIV/AIDS, case manager harus memiliki pengetahuan dan keterampilan professional, nilai dan kapasitas personal, dan memfasilitasi berbagai hal dalam pelayanan. Kesuksesan yang diraih oleh case manager dalam pelayanan yang diberikan terkait dengan permasalahan orang dengan HIV/AIDS di pedesaan di Alaska dapat menjadi salah satu acuan serta menjadi contoh bagi para case manager dalam organisasi pelayanan manusia di Indonesia.
PRAKTIK INTERVENSI KRISIS DALAM PENANGANAN KASUS ANAK KORBAN KEKERASAN SEKSUAL (Studi pada Pekerja Sosial Di Balai Rehabilitasi Sosial Anak Yang Memerlukan Perlindungan Khusus –-BRSAMPK Paramita Mataram Provinsi Nusa Tenggara Barat)
Authors: Ramdyanti Baiq Dwicahya , Susilowati Ellya , Rahayuningsih Eni
Published: May 2023

Penelitian ini bertujuan untuk memperoleh gambaran tentang praktik “Intervensi Krisis’ yang dilakukan oleh Pekerja Sosial Dalam Menangani Kasus Anak Korban Kekerasan Seksual di Balai Rehabilitasi Sosial Anak yang Memerlukan Perlindungan Khusus (BRSAMPK) Paramita Mataram”. Konsep Intervensi krisis merujuk pada model Robert (2005) tentang tujuh tahapan dalam pelaksanaan intervensi krisis. Metoda Penelitian yang digunakan adalah metode kualitatif dengan deskriptif. Pengumpulan data menggunakan wawancara mendalam, observasi non partisipatif kepada dua informan pekerka sosial yang sedang menangani kasus korban kekerasan seksual, serta studi dokumentasi pada laporan mereka. Hasil penelitian menunjukkan bahwa pekerja sosial melakukan intervensi krisis dengan tahapan berikut : 1) perencanaan dan penilaian krisis (lethality); 2) membangun hubungan psikologis dengan klien; 3) mengidentifikasi kasus utam; a 4) melakukan ekslporasi perasaan ; 5) eksplorasi alternatif masa lalu anak korban kekerasan seksual 6) penyusunan rencana tindakan 7) menyussn rencana tindak lanjut dalam melakukan intervensi krisis. Namun demikian dalam praktik tersebut masih perlu peningkatan berkaitan dengan keterampilan Pekerja Sosial dalam komunikasi interpersonal dengan anak korban kekerasan seksual. Sehubungan tersebut maka direkomendasikan program “Penguatan Keterampilan Komunikasi Interpersonal Pekerja Sosial Melalui Educational Group di Balai Rehabilitasi Sosial Anak yang Memerlukan Perlindungan Khusus Paramita Mataram”.
Emerging Trends of West phobia in Muslim Societies and Islamophobia in Western Societies: Reasons and Remedies
Authors: Fatima Samza , Imam Syed Kaleem , Raza Mohsin
Published: May 2023

Religion remains a significant source of intolerance, discrimination, and marginalization all across the world, despite efforts to eradicate it. In recent times, religious activities have fostered fear, suspicion, and other bad sentiments among their respective believers, rather than fostering unity and mutual tolerance. In the media, there is a common refrain claiming Islam is the cause of a string of terrorist incidents. Resultantly, various governments are anxious about and mistrust of Muslims (Islamophobia), and on the other side, a western phobia is on the increase. This paper systematically reviews the aspects of Islamophobia and western phobia that have repercussions for peace in the world and peaceful coexistence. According to the findings of the study, an increase in Islamophobic attacks and religious intolerance around the world has presented a grave risk to global concord and unity.
Analyzing the Internal Factors Contributing to Balochistan Insurgency
Authors: Afridi Manzoor Khan , Khattak Masood , Ullah Muhammad Usman
Published: May 2023

This research paper will investigate the internal factors regarding the Balochistan insurgency. This province has become the victim of violence and insurgent factors from the last many decades due to multiple factors such as unequal distribution of resources, and tribal and kinship systems. Moreover, this paper will also discuss the political, economic and social development in the province. In the end, some recommendations and ways forward would also be provided for the betterment of Balochistan.
Impact of Feudal on Pakistani Politics: A Case Study of District Vehari
Authors: Ahmad Basher , Nawaz Muhammad Ahmad
Published: May 2023

Federalism Feudalism is a system in which some personalities take part and take control of all the activities of this system. These prominent personalities are called feudal lords. This system has remained in different countries in different forms. The research topic is "The Impact of Feudal in Pakistani Politics: A case study of district Vehari" which shows that Pakistan is one of those countries that have feudal systems. The researcher focused mainly on the impacts of feudal in three tehsils (Mailsi, Vehari and Burewala) of district Vehari. The sample size was 300 from three tehsils of Vehari in an equal basis for survey conduct. The researcher constructed a questionnaire as a survey tool which was given to the respondents according to their gender, education, age and residential areas. On the behalf of gathered data, the researcher concluded that the feudal in district Vehari has dominate impact on Pakistani politics.
Utah geosite—the Salina Canyon unconformity, a classic example of missing time
Authors: Judge Shelley , Werthmann Emmett , Millan Cristina , Braunagel Michael , Maletic Erica
Published: May 2023

Salina Canyon, Utah, reveals a spectacular angular unconformity along an east-west transect through the southern part of the Wasatch Plateau. This region of Utah is well known as the eastern extent of Sevier orogenesis, but it also includes subsequent extensional overprinting. Earliest descriptions of this unconformity were published by Dutton (1880) and Spieker (1946, 1949), and work continues today. Field relationships expose many classic stratigraphic and sedimentologic features of erosional surfaces. Due to the geometry of the progressive unconformity onto the topographic high of the Sanpete-Sevier Valley antiform, the angular discordance of strata results in a gap in time of greater than 107 million years in the west, decreasing toward the east to about 39 million years and finally to less than 17 million years. Paleosols and small-scale channels/scours with infilled basal conglomerates are also prominent along the unconformity, as are several mine adits. Because of its abundant geologic features, the Salina Canyon unconformity is a superb teaching and learning space for geoscientists and outdoor naturalists.
Системний аналіз у соціології
Authors: Туленков Микола Васильович , Лобанова Алла Степанівна , Яремчук Сергій Степанович
Published: May 2023

Розглянуто джерела генезису і концептуальної еволюції системного світогляду, історичні етапи становлення та розвитку загальної теорії систем і системного аналізу, а також їхнє місце і роль у структурі сучасного наукового знання. Поряд із цим, проаналізовано понятійно-категоріальний апарат системної теорії і системного аналізу, системні закони, закономірності і принципи, а також логіка, методологія, методика і методи системних досліджень. Системний підхід у контексті соціологічної науки подається як продуктивний засіб створення системних концепцій і визначальний принцип системного аналізу складних соціальних об’єктів, явищ і процесів, а також як універсальна технологія пізнання природи, характеру й особливостей різних соціальних утворень у перебігу їх функціонування та розвитку в умовах глобальних соціально-економічних,політичних і соціокультурних трансформацій сучасного суспільства. Призначений для науковців, викладачів, аспіратів, студентів і усіх тих, хто цікавиться актуальними питаннями формування системного світогляду,необхідністю пізнання системних законів і принципів з метою предметного розуміння сучасного суспільного буття, а також можливістю використання системної методології та системного аналізу в процесі організації конкретних соціологічних досліджень.
METODE ANALYTICAL HIERARCHY PROCESS (AHP) DAN BORDA DALAM PERENCANAAN DAN PENGADAAN OBAT DI PUSKESMAS
Authors: Pratiwi Lely Ira , Hartono Budi , Abidin Zainal , Yunita Jasrina , Mishbahuddin Mishbahuddin
Published: May 2023

Latar Belakang: Pada tahun 2020 UPT Puskesmas Balai Makam mengalami masalah terjadinya kekosongan obat. Berdasarkan laporan ketersediaan obat dan vaksin esensial Puskesmas dari Dinkes  Kab. Bengkalis  dari 17 Puskesmas yang terdapat di Kabupaten Bengkalis, UPT Puskesmas Balai Makam menempati urutan ketiga dengan ketersediaan obat dan vaksin sebesar 68,33 %Tujuan: menganalisa perencanaan dan pengadaan persediaan farmasi dan Bahan Medis Habis Pakai (BMHP) di UPT Puskesmas Balai Makam. Metodologi: Jenis penelitian kualitatif dengan desain deskriptif menggunakan Analytical Hierarchy Process (AHP) dan Borda. Metode pengambilan data dengan wawancara mendalam kepada 8 (delapan) orang informan terpilih yang dinilai sebagai ahli (expert). Hasil:  Analysis  Hierarchi  Process  (AHP) diperoleh  kriteria yang terpilih adalah SDM sebesar 46 %, kriteria ini sebagai support management dalam kegiatan perencanaan dan pengadaan sediaan farmasi dan BMHP. Alternatif pemecahan masalah SDM melalui monitoring dan evaluasi kinerja SDM. Diskusi: kriteria dengan bobot prioritas tertinggi adalah Sumber Daya Manusia dan alternative pemecahan masalah yang mendapat  bobot  rangking  tertinggi  adalah  monitoring  dan  evaluasi  kinerja Sumber Daya Manusia secara berkala. Perlu peningkatan evalusi internal dari pihak UPT Puskesmas Balai Makam serta pihak Dinas Kesehatan Kab. Bengkalis.
ANALISIS PELAKSANAAN KEGIATAN PERILAKU HIDUP BERSIH DAN SEHAT PADA PROGRAM UKS DI SEKOLAH DASAR
Authors: Aidha Zuhrina , Mardhiyah Lailatul , Manalu Gadis Permata Hati , Nisha Devika May , Putri Karina Aulia
Published: May 2023

Latar belakang: Pola Hidup Bersih dan Sehat di sekolah merupakan kegiatan memperdayakan siswa, guru dan masyarakat lingkungan sekolah untuk melakukan pola hidup sehat menciptakan sekolah sehat meliputi  mencuci tangan dengan sabun sebelum dan sesudah makan, mengonsumsi jajanan sehat, menggunakan jamban bersih dan sehat, olahraga teratur, memberantas jentik nyamuk, tidak merokok, membuang sampah pada tempatnya dan melakukan kerja bakti bersama warga lingkungan sekolah untuk menciptakan lingkungan yang sehat. Tujuan: untuk mengidentifikasi Program PHBS yang disekolah tersebut, dimana Program PHBS sebagai bagian dari UKS merupakan salah satu program yang sudah berjalan cukup lama di sekolah ini. Metodologi: Jenis penelitian ini adalah penelitian kualitatif. Pengumpulan data dilakukan dengan cara observasi, wawancara, dokumentasi, dan triangulasi. Hasil: Program PHBS ini sudah berjalan dengan baik. Hal ini ditandai dengan sudah berjalannya 6 indikator dari 8 indikator PHBS pada tatanan sekolah. Namun dari program ini masih memiliki hambatan. Hambatan dari program ini adalah kurangnya rasa peduli terhadap kebersihan dan cinta akan kesehatan diri sendiri. Diskusi: Pihak sekolah harus semakin meningkatkan kinerja dalam pemenuhan indikator PHBS pada tatanan sekolah. Salah satunya yaitu indikator pemberantasan jentik nyamuk. Serta peningkatan pengembangan SDM yaitu para guru, staf ataupun masyarakat sekolah yang dapat memberikan edikasi kepada para siswa/siswi
PENGARUH PIJAT OKSITOSIN TERHADAP KELANCARAN PRODUKSI ASI PADA IBU POST PARTUM
Authors: Marantika Septi , Choirunissa Risza , Kundaryanti Rini
Published: May 2023

Latar Belakang: Kelancaran produksi ASI merupakan faktor utama tercapainya pemberian ASI ekslusif di Indonesia. Namun, ada bebarapa ibu yang mengalami ketidak lancaran produksi ASI. Penyebab ketidak lancaran produksi ASI adalah kurangnya rangsangan hormon oksitosin dan prolaktin yang berperan dalam kelancaran produksi ASI, sehingga dibutuhkan upaya alternatif berupa pijat oksitosin. Tujuan: Mengetahui pengaruh pijat oksitosin terhadap kelancaran produksi ASI pada ibu post partum di TPMB.R Kota Bekasi. Metodologi: Penelitian quasy eksperiment dengan menggunakan two group Pretest-Posttest Design. Sampel sebanyak 30 ibu post partum hari pertama sampai hari ketiga yang dibagi menjadi 2 kelompok, kelompok eksperimen diberi perlakuan pijat oksitosin dan kelompok kontrol tidak diberikan perlakuan. Sampel diambil menggunakan teknik purposive sampling. Instrumen yang digunakan lembar kuesioner, lembar observasi, baby oil, kom kecil, waslap, handuk, dan informed consent. Uji normalitas data menggunakan uji Shapiro Wilk, uji homogenitas menggunakan uji levene dan analisis data menggunakan uji Paired T Test untuk mengetahui perbedaan nilai rata-rata sebelum dan sesudah diberikan intervensi pada masing-masing kelompok, uji Independent T Test untuk menganalisis rata-rata perbedaan kelancaran produksi ASI sesudah diberikan intervensi pada kelompok kontrol dan kelompok perlakuan. Hasil: Hasil penelitian menunjukkan terdapat perbedaan kelancaran produksi ASI sebelum dan sesudah diberikan intervensi pijat oksitosin dengan hasil P-value=0,000(<0,05), nilai rata-rata kelancaran produksi ASI menunjukkan hasil pijat oksitosin efektif terhadap kelancaran produksi ASI. Kesimpulan: Terdapat pengaruh pemberian pijat oksitosin terhadap kelancaran produksi ASI pada ibu post partum di TPMB.R kota Bekasi tahun 2022. Saran: Diharapkan pijat oksitosin dapat dijadikan salah satu alternatif dalam meningkatkan produksi ASI pada ibu post partum.
Increased Cerebrospinal Fluid Levels of Soluble Triggering Receptor Expressed on Myeloid Cells 2 and Chitinase-3-Like Protein 1 in Idiopathic Normal-Pressure Hydrocephalus
Authors: Yang Fuxia , Yang Lu , Fang Xuhao , Deng Yao , Mao Renling , Yan Aijuan , Wei Wenshi
Published: May 2023

Background:

Neurodegenerative disease pathology is associated with neuroinflammation, but evidence on idiopathic normal pressure hydrocephalus (iNPH) remains limited and cerebrospinal fluid (CSF) biomarker profiles need to be elucidated.

Objective:

To investigate whether iNPH pathological mechanisms are associated with greater CSF markers of core Alzheimer’s disease pathology (amyloid-β42 (Aβ42), phosphorylated tau (P-tau)), neurodegeneration (total tau (T-tau)), and neuroinflammation (soluble triggering receptor expressed on myeloid cells 2 (sTREM2), chitinase-3-like protein 1 (YKL-40)).

Methods:

The study analyzed lumbar CSF samples from 63 patients with iNPH and 20 age-matched orthopedic surgery patients who had no preoperative gait or cognitive impairment (control group). Aβ42, T-tau, P-tau, sTREM2, and YKL-40 in different subgroups were investigated.

Results:

CSF sTREM2 levels were significantly higher in the iNPH group than in the control group, but no significant between-group difference was noted in YKL-40. Moreover, YKL-40 levels were significantly higher in the tap test non-responders than in the tap test responders ( p = 0.021). At the 1-year follow-up after shunt surgery, the CSF P-tau levels were significantly lower ( p = 0.020) in those with gait improvement and the CSF sTREM2 levels were significantly lower ( p = 0.041) in those with cognitive improvement. In subgroup analysis, CSF sTREM2 levels were strongly correlated with CSF YKL-40 in the iNPH group ( r = 0.443, p < 0.001), especially in the tap test non-responders ( r = 0.653, p = 0.002).

Conclusion:

YKL-40 and sTREM2 are disease-specific markers of neuroinflammation, showing higher CSF levels in iNPH. In addition, sTREM2 is positively associated with YKL-40, indicating that interactions of glial cells play an important role in iNPH pathogenesis.
The Adult Neurogenesis Theory of Alzheimer’s Disease
Authors: Abbate Carlo
Published: May 2023

Alzheimer’s disease starts in neural stem cells (NSCs) in the niches of adult neurogenesis. All primary factors responsible for pathological tau hyperphosphorylation are inherent to adult neurogenesis and migration. However, when amyloid pathology is present, it strongly amplifies tau pathogenesis. Indeed, the progressive accumulation of extracellular amyloid-β deposits in the brain triggers a state of chronic inflammation by microglia. Microglial activation has a significant pro-neurogenic effect that fosters the process of adult neurogenesis and supports neuronal migration. Unfortunately, this “reactive” pro-neurogenic activity ultimately perturbs homeostatic equilibrium in the niches of adult neurogenesis by amplifying tau pathogenesis in AD. This scenario involves NSCs in the subgranular zone of the hippocampal dentate gyrus in late-onset AD (LOAD) and NSCs in the ventricular-subventricular zone along the lateral ventricles in early-onset AD (EOAD), including familial AD (FAD). Neuroblasts carrying the initial seed of tau pathology travel throughout the brain via neuronal migration driven by complex signals and convey the disease from the niches of adult neurogenesis to near (LOAD) or distant (EOAD) brain regions. In these locations, or in close proximity, a focus of degeneration begins to develop. Then, tau pathology spreads from the initial foci to large neuronal networks along neural connections through neuron-to-neuron transmission.
Improving Blood Donor Care in a Collection Center Through Advanced Data Exploitation
Authors: Bottinelli Alice V. , Pozzi Silvia , Zanni Alessia , Lanzarone Ettore
Published: May 2023

Background: Blood collection centers can take advantage of the huge amount of data collected on donors over the years to predict and detect early the onset of several diseases, However, dedicated tools are needed to carry out these analyses. Objectives: This work develops a tool that combines available data with predictive tools to provide alerts to physicians and enable them to effectively visualize the history of critical donors in terms of the parameters that led to the alert. Methods: The developed tool consists of data exchanging functions, interfaces to raise alerts and visualize donor history, and predictive algorithms. It was designed to be simple, modular and flexible. Results: A prototype was applied to the Milan department of the Associazione Volontari Italiani Sangue, and was deemed suitable for prevention and early diagnosis objectives by the physicians of the center. The included Machine Learning predictive algorithms provided good estimates for the variables considered in the prototype. Conclusion: Prevention and early diagnosis activities in blood collection centers can be effectively supported by properly using and displaying donor clinical data through a dedicated software tool.
Fading Fatigue – A Self-Management App for Supporting Long-COVID Patients with Fatigue
Authors: Schmid Daniel S. , Moser Denis S. , Denecke Kerstin
Published: May 2023

Fatigue is the most prevalent Long-COVID symptom. Individuals who are affected have to learn to organize and manage daily activities according to the subjectively perceived energy reserves. Our objective was to develop an application, Fading Fatigue, that supports patients in their energy management, in particular after an initial therapy guided by health professionals. Fading Fatigue was developed in an iterative approach and implemented as a client-server application. Interviews and a literature search were conducted to identify limitations and challenges of the current treatment. Fading Fatigue offers several tools for energy management: a daily energy planner, a documentation aid for well-being and a progress view. Future work should study usability. Inclusion of additional features increasing the adherence such as providing feedback could be considered.
Real-Time Digital Feedback for Exercise Therapy of Lower Extremity Functional Deficits: A Mixed Methods Study of User Requirements
Authors: Widhalm Klaus , Maul Lukas , Durstberger Sebastian , Klupper Carissa , Putz Peter
Published: May 2023

Background: Relearning physiological movement patterns is a key factor to success in the treatment of functional deficits. Motivation to train sustainably is essential for successful motor re-education and can be promoted by instrumentally supported real-time feedback. Objectives: Study findings should improve the understanding of real-time feedback visualization for exercises targeting the lower extremities. Methods: A mixed-methods survey on recognition, comprehensibility, color scheme and shape of six real-time feedback prototype visualizations was conducted among three user groups (physicians, physiotherapists, and patients). Results: The mean correct recognition of body regions visualized in the feedback was 55 %, ranging from 29 % to 74 %. Comprehensibility, color scheme and shape were best received for feedback with clear visual guidance, sympathetic and motivating color schemes and abstract visualizations of body regions. Conclusion: Insights were gathered for the design, optimization, and customization of visualizations to develop a real-time feedback prototype.
Usability Testing of a Multi-Level Modeling Framework for Just-in-Time Adaptive Interventions (JITAIs) in Mobile Health
Authors: Gruber Sebastian , Neumayr Bernd , Wurhofer Daniela , Smeddinck Jan David
Published: May 2023

The JITAI is an intervention design to support health behavior change. We designed a multi-level modeling framework for JITAIs and developed a proof-of-concept prototype (POC). This study aimed at investigating the usability of the POC by conducting two usability tests with students. We assessed the usability and the students’ workload and success in completing tasks. In the second usability test, however, they faced difficulties in completing the tasks. We will work on hiding the complexity of the framework as well as improving the frontend and the instructions.
First Clinical Experiences with the New DICOM Neurophysiology Standard
Authors: Lang Clemens , Winkler Silvia , Koren Johannes , Gritsch Gerhard , Kluge Tilmann , Baumgartner Christoph
Published: May 2023

Background: Exchange of EEG data among institutions is complicated due to vendor-specific proprietary EEG file formats. The DICOM standard, which has long been used for storage and exchange of imaging studies, was expanded to store neurophysiology data in 2020. Objectives: To implement DICOM as an interoperable and vendor-independent storage format for EEG recordings in the Clinic Hietzing. Methods: A pilot implementation for automated conversion of EEG data from a proprietary to standardized DICOM format was developed. Additionally, EEG review based on a central DICOM archive in a DICOM EEG viewer (encevis by AIT) was implemented. Results: More than 200 long-term video EEG recordings and over 3000 routine EEGs were archived to the central DICOM archive of the WIGEV. Conclusion: Using DICOM as a storage format for EEG data is feasible and leads to a substantial improvement of interoperability and facilitates data exchange between institutions.
Improving Emergency Service Quality and Patient Safety Through the Use of Cross-Sectoral Digital Feedback Systems – An Overview
Authors: Klausen Andreas , Stanke Kristin , Wulff Antje
Published: May 2023

Background: Feedback is essential for personal and professional development, also in emergency services. However, EMS usually ends at the interface with the emergency department, thus, the long-term effect of initiated emergency measures often remains unclear for emergency personnel. Digital, data-driven tools providing systematic feedback on patients’ outcome may be valuable to improve emergency service quality and patient safety. Objectives: To provide an overview about current approaches for cross-sectoral digital feedback systems in EMS. Methods: Literature review in PubMed/MEDLINE and Google Scholar in accordance with the PRISMA statement. Results: The search resulted in 567 articles out of which only three were identified as eligible. In only one study cross-sectoral feedback was used to improve quality. Conclusion: Although feedback is described as a method for improving the quality of the rescue service and feedback is also considered in the description of the requirements for digitization, there seems to be no technical implementation of a cross-sectoral feedback system so far.
The Surviral Epidemiological Early Warning System Tyrol Dashboard – System, Functionality and Findings
Authors: Neururer Sabrina B. , Schweitzer Marco , Hackl Werner O. , Tilg Bernhard , Siegele Johann , Raudaschl Patrick , Pfeifer Bernhard
Published: May 2023

Background: Dashboards provide a good retrospective view of the development of the disease. Yet, current COVID-related dashboards typically lack the capability to predict future trends. However, this is important for health policy makers and health care providers in order to adopt meaningful containment strategies. Objectives: The aim of this paper is to present the Surviral dashboard, which allows the effective monitoring of infectious disease dynamics. Methods: The presented dashboard comprises a wide range of information, including retrospective and prognostic data based on an agent-based simulation framework. It served as the basis for informed decision-making and planning of disease control strategies within the federal state of Tyrol. Results: By visualizing the information in an understandable format, the dashboard provided a comprehensive overview of the COVID-19 situation in Tyrol and allowed for the identification of trends and patterns. Conclusion: The presented dashboard is a valuable tool for managing pandemics such as COVID-19. It provides a convenient and efficient way to monitor the spread of a disease and identify potential areas for intervention.
Prescribing Behavior and Reasonable Price for Mental Health DiGAs – Results of a Pilot Study
Authors: Seitz Kevin , Scholtes Michael , Mueller Tobias
Published: May 2023

Background: Since the Digital Health Care Act came into force in 2020, mHealth services can be prescribed and reimbursed as DiGAs in Germany. The most reimbursable DiGAs can be found in the area of psychiatric diseases. Little is known about the prescribing behavior of medical and psychological psychotherapists and the price they considered reasonable. Objectives: To gather more detailed knowledge about the prescription behavior, appropriate diagnosis, reasonable price and importance of relevant characteristics. Methods: Online survey of 38 medical and psychological psychotherapists working in central Hesse. Results: Just under a third have prescribed DiGAs to date; suitable diagnoses include somatoform disorders, anxiety disorders and addictive disorders. Medical quality, user- friendliness and data protection are considered important. the reasonable price is below the current average market price. Conclusion: The DiGAs do not seem to be prescribed by psychotherapists on a broad scale yet, the suitable indications are in line with the market offer, although the prices seem to be too high from the prescribers’ point of view.
Extending a Data Management Maturity Model for Process Mining in Healthcare
Authors: Erhard Andreas , Arthofer Klaus , Helm Emmanuel
Published: May 2023

Background: Many components must work together to continuously improve processes in healthcare organizations. Process mining has recently developed into a discipline that can make a significant contribution here. Objectives: We want to extend an existing management tool to assess and improve the capability of organizations in this area. Method: We add a dimension to the adoption readiness assessment and maturity model for sharable clinical pathways to assess and improve event data quality. Results: We present different approaches for formal and checkpoint assessments and an embedding of the improvement strategy with examples. Conclusion: The additional dimension from the process mining domain integrates with the existing model. At all levels, links can be established between the various aspects of event data quality with existing dimensions. The model has yet to be tested in a real-world use case.
Integrating a Novel Eye Imaging System into Clinical Practice: An Open-Source DICOM Simulation Platform
Authors: Schweitzer Marco , Flórez Katherine , Steger Bernhard , Baumgarten Daniel , Romano Vito , Augustin Marco
Published: May 2023

Background: The integration of innovative imaging technologies into clinical workflows requires the utilization of a standardized data exchange format. The “Digital Imaging and Communications in Medicine” (DICOM) standard is widely used in healthcare to process and transfer medical images. However, no simulation environment is ready to use for development. The objective of this paper is to provide an open-source DICOM platform for integrating a novel ocular photography system into a clinical setting. Methods: After a thorough analysis of the available open-source tools, a subset was selected and aligned with the U-Eyecare Profile of Integrating the Healthcare Enterprise (IHE). Results: Orthanc served as a PACS with a modality worklist and the OHIF-Viewer for image retrieval. Minimal interfaces for the electronic health record and image modality were created. Docker-compose further integrates all components and simulates the network protocols DICOM Message Service Element and DICOMWeb. Discussion: The platform was used to develop and integrate the developed image modality and will be further utilized for teleophthalmology and processing eye images. The platform could be useful for other researchers to integrate an image modality into a clinical environment along IHE.
Impact of Professional Background on Inter-Annotator Variability and Accuracy During Annotation of Clinical Notes
Authors: Weishäupl Kristina , Schuster Mario , Mayrl Christina , Humberger Diana , Hoffstädter Antonia , Fischer Theresa , Punz-Reidlinger Bianca , Wiesmüller Fabian , Lauschensky Aaron , Hayn Dieter , Kreiner Karl , Fetz Bettina , Brunelli Luca , Poelzl Gerhard , Pfeifer Bernhard , Slamanig Gerald , Neururer Sabrina Barbara , Schreier Günter
Published: May 2023

Background: The aging population’s need for treatment of chronic diseases is exhibiting a marked increase in urgency, with heart failure being one of the most severe diseases in this regard. To improve outpatient care of these patients and reduce hospitalization rates, the telemedical disease management program HerzMobil was developed in the past. Objective: This work aims to analyze the inter-annotator variability among two professional groups (healthcare and engineering) involved in this program’s annotation process of free-text clinical notes using categories. Methods: A dataset of 1,300 text snippets was annotated by 13 annotators with different backgrounds. Inter-annotator variability and accuracy were evaluated using the F1-score and analyzed for differences between categories, annotators, and their professional backgrounds. Results: The results show a significant difference between note categories concerning inter-annotator variability (p<0.0001) and accuracy (p<0.0001). However, there was no statistically significant difference between the two annotator groups, neither concerning inter-annotator variability (p=0.15) nor accuracy (p=0.84). Conclusion: Professional background had no significant impact on the annotation of free-text HerzMobil notes.
Afección psicopatológica de la mujer víctima de violencia
Authors: Lara Caba Evelyn Zoraya , Pérez-Estévez Lisanna
Published: May 2023

El estudio realizado en la República Dominicana consistió en evaluar la relación entre violencia experimentada y depresión, ansiedad, ideación suicida, quejas somáticas, trastorno de estrés postraumático, autoestima y apoyo social. Metodología: Estudio transversal y correlacional con 170 mujeres que buscaron ayuda psicológica. Resultados: la edad media fue 38.5. Se observó una correlación positiva significativa débil entre Trastorno por Estrés Post Traumático y la violencia psicológica por control, humillación, violencia física y sexual. La depresión presentó una correlación significativa débil con violencia psicológica por control, humillación y violencia sexual. Hubo una relación negativa significativa débil entre depresión y autoestima. Conclusión: se encontraron correlaciones significativas entre haber sufrido violencia y los síntomas. Estos resultados aportan al ejercicio forense y en la intervención psicológica.
Apoyo Social en Mujeres Inmigrantes de Valparaíso, Chile
Authors: Vilugrón Fabiola , Sánchez Ximena , Casanueva Daniela , Arcos Estela
Published: May 2023

El apoyo social es un recurso para la calidad de vida de mujeres inmigrantes y constituye capital social. El objetivo fue identificar frecuencia y satisfacción del apoyo social percibido y recibido por mujeres inmigrantes de Centros de Salud de Valparaíso. Estudio con diseño no experimental, transversal, descriptivo, mediante una encuesta social. Se aplicó el Cuestionario de Apoyo Social Percibido y Recibido y preguntas sociodemográficas a 227 mujeres de entre 18 y 44 años. Se utilizaron estadística descriptiva, r de Pearson y análisis de varianza. Los resultados sugieren que el país de nacimiento, estado civil, educación, años en Chile, motivos de migración, vivienda, número de personas con que vive, trabajo, situación migratoria y diagnóstico de enfermedades se relacionan con frecuencia y satisfacción del apoyo social percibido y recibido. El apoyo social informacional, material o emocional, proveniente de redes de inmigrantes contribuye a su integración en la sociedad de acogida.
El uso problemático del smartphone y la autoestima: un meta-análisis
Authors: Hidalgo-Fuentes Sergio
Published: May 2023

El uso problemático del smartphone ha sido catalogado como un problema de salud pública por la Organización Mundial de la Salud. El objetivo del presente trabajo es examinar la relación entre el uso problemático del smartphone y la autoestima. Se realizó una búsqueda bibliográfica en las bases de datos PsycInfo, PubMed y Scopus recuperando un total de 30 estudios relevantes con una muestra total de 20916 participantes. El tamaño del efecto obtenido mediante un modelo de efectos aleatorios es significativo y negativo (r = -.25; IC 95% = -.28, -.21), por lo que las personas que poseen una menor autoestima, presentan mayores niveles de uso problemático del smartphone. Los análisis de meta-regresión mostraron que el sexo y la edad no son variables moderadoras estadísticamente significativas. No se aprecia riesgo de sesgo de publicación. Se presentan las limitaciones y las implicaciones prácticas del trabajo.