bluuebunny/crossref_metadata_2025 huggingface dataset:
The use of geoinformation systems in forestry and forestry industry
Authors: Mironova Yuliya
Published: March 2022

The article discusses aspects of the application of geoinformation systems in forestry. Rational use, conservation and restoration of forests in the modern world is becoming an increasingly complex urgent task. Forestry requires improving the quality of management and monitoring of forest resources, improving the perception of geoinformation in a user-accessible form. As the demand for natural resources grows, it becomes imperative that natural resource management plans be more understandable, more dynamic, accessible to the public, and take into account the many values associated with the forest, land and society. For example, ARC/INFO GIS is ideal for forestry management. ARC/INFO software is a powerful set of software tools for creating and editing geographical databases, for the purposes of spatial analysis, search, presentation and data management. Forest management planning includes making forecasts of how the forest will look as a result of certain management methods. Remote sensing and assessment of primary forest resources are also important. In order to practically use this valuable source of information, satellite image data must be geographically linked, adjusted to take into account the terrain and connected to such a technological infrastructure as GIS. With the help of integrated GIS, the needs of all persons related to forestry will be met through shared and shared access to objective information. Thus, it can be noted that recently there has been an active integration of geoinformation systems and forestry, which brings great benefits to both the first and the second science
Domestic violence as a social problem in contemporary Russian society
Authors: Slanova Angelica , Kabulashvili Kristina
Published: March 2022

The article is devoted to domestic (family) violence in modern Russian society. The problem of domestic violence has long ceased to be an individual’s problem. It harms not only the victim, but also the state and society as a whole. Every year in Russia, 14,000 women die at the hands of their husbands. In Russia, domestic violence was first officially reported in the early 1990s. It is necessary to take into account the fact that in the past centuries the patriarchal family dominated, in which women occupied subordinate positions. The woman had to obey her husband unquestioningly and endure the beatings. Children were brought up in the same way. Corporal punishment was mandatory in the family. There is no specific law against domestic violence in our country. Domestic violence also abhors moral and ethical values.

The authors looked at causes, varieties, statistics, cycles, the effects of domestic violence and ways to prevent domestic abuse in modern society. There are several forms of violence: physical, psychological, sexual and economic. The consequences of domestic violence are: self-harm, mental disorders, sleep disturbances, depression, anxiety, low self-esteem, alcohol or drug use, etc. Properly coordinated work by health care, law enforcement, and social services agencies can play an important role in preventing domestic violence. At the same time, both individual and general social prevention with young people should be carried out in order to prevent domestic violence and, of course, to introduce a law against domestic violence.
Vertical Fracability Model on Lithofacies Association of Brownshale Formation from Outcrop Analog Using Rock Mechanical and Mineralogy Correlation Method: A Preliminary Study of Shale Hydrocarbon Development in Bengkalis Trough, Central Sumatra Basin
Authors: Buntoro Aris , Prasetyadi C. , Wibowo Ricky Adi , Suranto Suranto
Published: March 2022

DOI:10.17014/ijog.9.1.87-104In the production stage of shale hydrocarbon with very low permeability, an in-depth analysis of the mechanism governing hydraulic fracking is required to open natural fractures, so that the fractures are connected to allow maximum flow of hydrocarbon fluids. This study is dedicated to create a vertical fracability model of shale hydrocarbon as a basis for planning the optimal position combination of horizontal well with multistage hydraulic fracking based on the correlation of rock mechanical and mineralogy analysis. Because in-situ core data is not available, this study uses shale core and shale sample data from outcrop analog (surface) as as a representative of the Brownshale Formation in the Central Sumatra Basin. At present, Indonesia has a very large potential for shale hydrocarbon, mainly from the Brownshale Formation of Pematang Group as the main source rock in the Central Sumatra Basin, which spread over several troughs, namely: Balam, Rangau, Kiri, Aman, and Bengkalis, where Bengkalis trough has the largest area compared to others, so it was chosen as the research target. In creating the vertical fracability model, information about the elastic rock properties, namely Young's Modulus (YM) and Poisson's ratio (PR) are needed as the basis for determining the depth interval of the formation with high fracability. Fortunately, at this time there was a very good outcrop analog at the coal mine site of PT. Karbindo in Kiliranjao, and there were also several outcrop analog locations in Limapuluh Koto area, West Sumatra. The vertical fracability model of shale hydrocarbon of the Brownshale Formation shows an interesting phenomenon, where the sweetspot fracable window interval is in the low YM - high PR zone, so it can be concluded that the low YM - high PR zone is a good candidate for hydraulic fracking. In contrast, the fracture barrier interval is in the high YM - high PR and low YM - low PR zones, where both are correlated with high Brittleness Index (BI), but the Fracability Index (FI) is low. I t can be concluded that high YM - high PR and low YM - low PR are inappropriate interval as a candidate for hydraulic fracking. This phenomenon is confirmed by the presence of a dominant carbonate mineral at the upper section as fracture barrier, while at the lower section as a sweetspot fracable window, which is more dominated by quartz mineral.
Sumario
Authors: Rodríguez-Muñiz Luis J.
Published: March 2022

Sin resumen
Rancangan Desain Sistem Monitoring Home Quarantine Kasus Konfirmasi Tanpa Gejala Covid-19 Berbasis Web-Mobile Di Surabaya
Authors: Indrihapsari Hamidah , Prasetyo Sabarinah , Siregar Kemal Nazaruddin
Published: March 2022

As a new emerging and highly infectious disease, the cases of Coronavirus Disease (COVID-2019) have been growing rapidly. To curb the spread of COVID-19, one of the measures is quarantining the patients who are infected in the hospital or in a dedicated monitoring center. However, because of the fast spread of the coronavirus, the health resources such as health facilities, healthcare workers, and monitoring centers, are overwhelmed. To handle this problem, asymptomatic patients are suggested to self-quarantine in their own home. However, this can be challenging because it is hard to monitor these patients all the time. Global Positioning System (GPS) & Geofencing technology can become solution for this issue, to monitor the COVID-19 patients by tracking the location of these home-quarantined patients. Web-mobile application for monitoring COVID-19 home-quarantined patients is proposed to handle the problems arising because of COVID-19. The prototyping method is used in this system development until step 2; 1) system requirement analysis, and 2) system design. System requirement analysis was done with qualitative method via online in-depth interviews with 5 (five) potential users (a staff from District Health Office of Surabaya, one from Primary Healthcare Centers in Surabaya, one surveillance staff, one doctor, and one asymptomatic COVID-19 patient from Surabaya) and literature review. System design consists of logic designs and interface designs which is designed to fulfill the requirements needed in the first step. Most of the potential users interviewed, stated that the development of this system will be really helpful for them, but it must be followed with the local regulation about the consequences of breaking the home quarantine rule. In conclusion, this system design can be the basic concept for developing the system in the next step.
Sarapan, Asupan Zat Gizi Makro Dan Cairan, Persepsi Kenyamanan Suhu Ruang Terhadap Persepsi Kinerja Pekerja
Authors: Wulandari Selly Apliyanti , Jus’at Idrus , Mulyani Erry Yudhya , Sa’pang Mertien , Wahyuni Yulia
Published: March 2022

Sebuah perusahaan tentu ingin memiliki sumber daya manusia yang berkualitas sehingga dapat menghasilkan kinerja yang baik, tetapi terkadang banyak perusahaan yang tidak memperhatikan kesehatan pekerjanya terutama tentang gizi pekerjanya, karena gizi merupakan salah satu aspek penting dalam meningkatkan kinerja dan produktivitas. Tujuan: Untuk mengetahui hubungan sarapan, asupan zat gizi makro, asupan cairan, dan persepsi kenyamanan suhu ruang kerja terhadap persepsi kinerja pekerja di PT. Intan Pertiwi Industri. Metode: Penelitian ini menggunakan desain Cross Sectional yang merupakan variabel independen maupun variabel dependen diamati dan diukur pada saat yang bersamaan. Jumlah sampel 59 responden. Pengambilan data menggunakan angket dan food record 2x24 jam. Analisis bivariat yang digunakan menggunalan uji korelasi pearson. Hasil: Terdapat hubungan yang signifikan antara energi sarapan, asupan protein, asupan lemak, dan persepsi kenyamanan suhu ruang kerja dengan persepsi kinerja P-value  kurang dari atau sama dengan 0,05. Terdapat hubungan hampir signifikan (borderline) antara asupan karbohidrat, asupan cairan dengan persepsi kinerja P-value kurang dari atau sama dengan 0,1. Kesimpulan: Ada hubungan antara energi sarapan, asupan protein, asupan lemak, persepsi kenyamanan suhu ruang kerja dengan persepsi kinerja. Ada hubungan tetapi kurang signifikan antara asupan karbohidrat, asupan cairan dengan persepsi kinerja.
Mental illness vs mental retardation
Authors: Ahmad Mir Javaid , Mushtaq Bushra , Mushtaq Onaisa Aalia
Published: March 2022

Mental illness and mental retardation are completely two different terms and with two different concepts in them and cannot be used interchangeably. Mental illness can be caused by number of causes like genetic causes, environmental causes and chemical imbalances in the brain. While mental retardation in the imbalance in normal development of the brain in an individual by which it can be categorized into mild Estimates of the prevalence of comorbidity of psychiatric disorders and mental retardation in community and clinical populations range from 14.3 to 67.3 percent.

Mental illness can be described when behaviour of individuals is inappropriate, irrational, or unrealistic in most physical, or in mental illness the person’s behaviour is not normal. Mental disorder can be caused by physical, psychological or environmental factors, or a com- bination of all three. While mental illness is not level of intelligence, it is possible for a person to be both mentally ill and retarded.
Prostate cancer in a 16-year old — Is there a new shift?
Authors: Haritha V S , Rawat Shyamji , Tiwari Mishi , Verma Rahul R
Published: March 2022

Prostrate cancer is predominantly known to be a cancer affecting elderly men with a median age of presentation being 68 years. So, most current guidelines suggest screening for prostrate cancer in men over 50 years. But, with changes in the environment and due to genetic factors prostrate cancer is nowadays being reported even in young men. However, patients with early onset prostrate cancer pose unique challenge as the clinical guidelines and prognosis of it in them is not well-defined. Here in we report a case of a 16-year-old boy who presented to us with lower urinary tract symptoms and was diagnosed to have advanced stage prostrate cancer.
La municipalidad de Paraná: contexto, actores y aspectos económicos (1860-1862)
Authors: Kozul Pedro
Published: March 2022

El presente artículo tiene como objetivo analizar las relaciones forjadas entre la municipalidad de Paraná con otras autoridades y actores locales, así como con el gobierno provincial de Entre Ríos, durante el proceso de organización del Estado nacional argentino. Reconstruimos sus tipos de ingresos, servicios y establecimientos que tuvo a su cargo, los problemas que debió afrontar y los perfiles de sus municipales. Además, consideramos las importantes transformaciones jurisdiccionales que experimentó esta ciudad tras la federalización de su territorio. Argumentamos que la municipalidad fue el primer cuerpo colegiado, con recursos propios y elegido por la comunidad de Paraná, cuyos miembros acompañaron la adquisición de potestades y prerrogativas que intentó concentrar una institución totalmente nueva en el espacio rioplatense.
The Impact of Integrated Marketing Communications on Customer Purchasing Decision in Yemen's Telecommunications Industry
Authors: Qasem Aayed , Aldumaini Najlaa , Alhakimi Wail
Published: March 2022

Nowadays, in the world of competition, customers seem to be fortunate. Since they have various alternative services and products, companies look for satisfying customers by providing good quality, price and promotion. So, entrepreneurs have to employ various means to stay competitive on the markets. This study aimed to investigate if the integrated marketing communications (IMC) of GSM companies have an impact on customers purchasing decision. The target population of this study were the customers of the GSM companies in Yemen. The main instrument used in collecting data was survey. The total of 385 questionnaires was distributed. Nonprobability/ convenience method of sampling was adopted in selecting a sample size. The study showed that there was positive impact of integrated marketing communications (IMC) on customers’ purchasing decision in the GSM companies in Yemen.The consequences of this study will provide GSM companies with useful data about excellent channels of integrated marketing communications (IMC) that should be used effectively to gain competitive benefits that lead to customers’ purchasing decision and maximize their sales.
Delay model based on shifted hyperexponential and Erlang distributions
Authors: Tarasov Veniamin N. , Bakhareva Nadezhda F.
Published: March 2022

This article is devoted to the derivation of results for the average delay of requests in the queue for a queuing system formed by two flows with the laws of interval distributions in the form of second-order hyperexponential and Erlang distributions shifted to the right. In queuing theory, studies of G/G/1 systems are relevant due to the fact that there is no solution in the final form for the general case. Therefore, in the study of such systems, various particular distribution laws are used as an arbitrary distribution law for G. In this case, the use of the hyperexponential distribution law ensures the coefficient of variation of the input flow intervals is large units, and the Erlang distribution is less than one. To solve the problem posed, the method of spectral decomposition of the solution of the integral Lindley equation was used, which plays an important role in the queueing theory. This method made it possible to obtain a solution for the average delay of requests in the queue for the system under consideration in a closed form. As is known, the remaining characteristics of the queuing system are derived from the average delay of requests.
Biographical Experiences of Post-Socialist Transformation in Corporate Business: Doing the Neoliberal Path
Authors: Domecka Markieta
Published: March 2022

The neoliberal order, introduced in Poland in the course of post-socialist transformation, constituted a context of action, as well as a repertoire of rules and practices people becoming corporate managers had to learn to cope with. As some took it for granted as ‘the only’ way of joining the economies of the idealised ‘West’, and through their daily practices of efficiency and profit-maximisation, they were actually doing the neoliberalism; others, maintaining the distance towards the new world of ‘freedom and opportunity’ managed to develop a more critical stand. These were not actively doing neoliberalism, but merely making do with it, taking it strategically or even instrumentally. In the paper, the role of biographical work and biographical knowledge is analysed in the process of distancing, which enables monitoring and negotiations of the relations between the acting self and the neoliberal context of action.
DIMENSI METRIK GRAF HASIL OPERASI JEMBATAN DARI CATERPILLAR HOMOGEN DAN POT BUNGA DIPERUMUM
Authors: Hidayanti Gusma , Amrullah Amrullah , Kurniati Nani , Hayati Laila
Published: March 2022

The metric dimension is a concept that has many applications, such as robotic navigation. This concept will distinguish each vertex of a graph based on some vertices. The distinguishing vertices are called the basis of the graph. Let G be a connected graph, the metric dimension, dim(G), is the smallest cardinality of the basis of graph G. On this paper, we present the metric dimensions of the bridge graph of a homogeneous caterpillar graph Cm,n and a generalized flower pot graph $C_p-K_{(q_1, q_2,\cdos,q_p}$. This research was conducted by the approach of structure analysis by location of the bridge vertices, the edge of the bridge, and the order of the graph. The results show that the metric dimensions of the bridge graph are at least can be reduced at most 2, and the maximum values are the same as the value of $m(n-1)+ \sum_{i=1}^p q_i- 2p$.Keywords: Metric dimension, caterpillar, unicyclic, bridgeMSC2020: 05C12
Operative difficulty in laparoscopic cholecystectomy: considering the role of machine learning platforms in clinical practice
Authors: Tranter-Entwistle Isaac , Eglinton Tim , Connor Saxon , Hugh Thomas J.
Published: March 2022

Aim: Computer vision is a subset of machine learning (ML) technology that allows automated analysis of large operative video datasets. The aim of this study was to use a commercially available ML-driven platform to evaluate a subjective grading of operative difficulty in laparoscopic cholecystectomy (LC). Methods: Patients undergoing LC prospectively consented, and their operations were recorded. The intra-operative findings were prospectively graded (1-4) based on intraoperative gallbladder appearance assessments. Deidentified videos were uploaded to Touch SurgeryTMand run through the platform’s algorithm, providing automated analytics including the total operative length and operative phase length. The rate of critical view of safety (CVS) achievement was also included in the analysis. Results: 206 LC were included. 27 LC were excluded due to incomplete video recording and were therefore not amenable to the final data analysis. Grade 1 and 2 patients had significantly shorter operative time than grade 3 and 4 patients [17min and 53s (IQR 15min and 24s- 21min and 38s) vs. 25 min and 49s (IQR 20min and 12s-38min and 38s) (P < 0.010)]. The operative phases for each step were significantly longer in patients with gallbladders graded 3 or 4 compared to those patients graded 1 or 2 (P < 0.043). The CVS was achieved in 94% of grade 1 patients, 88% of grade 2 patients, 85% of grade 3 patients and 73% of grade 4 patients (P = 0.177). Conclusion: Increased operative time and decreased ability to achieve the CVS with more difficult intraoperative findings supports the utility of the proposed grading system. ML in surgery is a nascent field, but this study demonstrates the potential of commercially available platforms for use in operative analytics, documentation, audit and training of future surgeons.
Research on Influencing Factors of Cross-Border E-commerce Enterprise Competitiveness
Authors: Hu Zhifang
Published: March 2022

The rise and prosperity of cross-border e-commerce has brought new development opportunities and great challenges to Chinese enterprises. By discussing the concepts and contents of cross-border e-commerce and enterprise competitiveness, this paper analyzes the influencing factors of enterprise competitiveness of cross-border e-commerce enterprises. By means of questionnaires and interviews with the management of relevant enterprises, the relevant data were obtained. In the dimensional analysis of cross-border e-commerce and enterprise competitiveness, the influencing factors of cross-border e-commerce enterprise competitiveness were discussed. The results show that the flat organizational structure is conducive to enhance the competitiveness of enterprises, and the fund management and human resource management play a more obvious role; The mastery of key technologies brings competitive advantages to enterprises. Because laws and regulations belong to the policy environment, compared with other factors, the impact on the competitiveness of enterprises is not obvious. To sum up, service level and customer satisfaction have the greatest impact on enterprise competitiveness; cost management and capital efficiency have a great impact on the competitiveness of enterprises; The conclusion that market demand has a relatively small impact on enterprise competitiveness.
О расчете транспортных свойств водного раствора на поровом уровне
Authors: Демьянов Александр Юрьевич , Dem'yanov Alexandr Yur'evich , Динариев Олег Юрьевич , Dinariev Oleg Yur'evich
Published: March 2022

Проведено прямое численное моделирование на поровом уровне транспорта многокомпонентного водного раствора, включающего в себя ионы соли и поверхностно активное вещество (ПАВ). Математическая модель учитывает формирование двойного электрического слоя (ДЭС) и адсорбцию ПАВ на границах жидкость -- твердое тело. Рассмотрены течения в реальных численных моделях пористых сред. На основании анализа результатов расчетов на поровом уровне (микромасштаб), приводится теория и строится интегральная расчетно-теоретическая модель для описания транспортных и термодинамических свойств на больших масштабах (макромасштаб), то есть решается задача термодинамического и транспортного апскейлинга.
Inventario de Sexismo Ambivalente (ISA) en adolescentes chilenos: estructura factorial, fiabilidad, validez e invarianza por sexo
Authors: Galván-Cabello Miguel
Published: March 2022

El sexismo ambivalente es un constructo multidimensional compuesto por creencias y actitudes hostiles y benévolas que se legitiman entre sí para justificar el poder masculino estructural. Los estudios sobre sexismo en adolescentes cobran relevancia al ser una etapa evolutiva fundamental para asentar creencias acerca de las relaciones de género. Sin embargo, los instrumentos para medir representaciones sexistas en este grupo son escasos. Este estudio evaluó las propiedades psicométricas del Inventario de Sexismo Ambivalente (ISA) en adolescentes chilenos, concretamente se analizó la estructura factorial y su fiabilidad, validez e invarianza factorial por sexo. La muestra estuvo conformada por 546 estudiantes entre 15 y 18 años (M=15.52; DT=.66), de los cuales el 58.8% fueron mujeres. Los métodos que se utilizaron fueron Análisis Factorial Exploratorio y Análisis Factorial Confirmatorio. El resultado del análisis exploratorio sugirió retener los 20 ítems de la escala original agrupados en dos factores. Los resultados del análisis confirmatorio corroboraron la estructura original de la escala y precisaron un modelo de dos factores correlacionados, Sexismo Hostil y Sexismo Benévolo (χ2 (166) = 302.34; CFI = .99; TLI = .98, RMSEA = .05, SRMR = .07), que considera al Sexismo Benévolo como un factor de segundo orden con tres subcomponentes (Paternalismo Protector, Intimidad Heterosexual y Diferenciación de Género). El modelo seleccionado coincidió con la propuesta teórica y explicó el 56% de la varianza. El análisis de fiabilidad indicó un alfa ordinal total de 0.93 y el análisis correlacional demostró evidencia de validez discriminante. El análisis de invarianza factorial evidenció que el grado de equivalencia del instrumento por sexo es plausible a un nivel estricto. Se concluyó que el ISA presenta adecuadas propiedades psicométricas para su uso en adolescentes de Chile. Palabras clave: Discriminación de Género; Estereotipos de Género; Propiedades psicométricas; Adolescencia; Estudio Instrumental.
Talla baja en la infancia y la adolescencia: psicopatología y estilo educativo familiar
Authors: Lacomba-Trejo Laura
Published: March 2022

Padecer talla baja (TB) durante la infancia o adolescencia puede asociarse con un mayor sufrimiento de clínica ansiosa y depresiva. Factores como los estilos parentales, el género, la edad, el tratamiento, las hospitalizaciones y la altura del adolescente y de sus progenitores pueden influir en el ajuste. El objetivo fue estudiar las variables personales y familiares que se asocian con un menor padecimiento de clínica ansiosa, depresiva y malestar emocional. Participaron 168 adolescentes con TB de entre 9 y 17 años (M=12,09; DT=2,07), siendo el 60,10%. Fueron evaluados mediante un registro ad hoc, la Escala Hospitalaria de Ansiedad y Depresión y la Escala de Estilos Parentales. Se realizaron análisis descriptivos, pruebas t de Student para muestras independientes, cálculo del tamaño del efecto, correlaciones de Pearson y regresiones jerárquicas. Los resultados evidenciaron que los estilos familiares positivos y un menor número de hospitalizaciones se asociaron con menor presencia de síntomas ansiosos y depresivos. Las chicas y quienes llevaban mayor tiempo con el diagnóstico de TB mostraron mayor comunicación con su familia. Los adolescentes con menor edad mostraron peor percepción de estilo parental. La edad, el tratamiento médico y la altura no se relacionaron con el ajuste psicológico. En la predicción de los síntomas ansiosos, depresivos y del malestar emocional fue relevante un mayor número de hospitalizaciones y menor promoción de la autonomía y control conductual. Destacamos la importancia de las variables familiares en el ajuste de los adolescentes con TB. Palabras clave: Talla baja; adolescencia; malestar emocional; estilos familiares.
Evidencias psicométricas de la Escala de Riesgo de Adicción-Adolescente en Redes Sociales e Internet en estudiantes peruanos
Authors: Gamboa-Melgar Goldie
Published: March 2022

El objetivo fue analizar las evidencias de validez y confiabilidad de la Escala de Riesgo de Adicción-adolescente a las Redes Sociales e Internet (ERARSI) en estudiantes peruanos. Participaron 755 estudiantes (52.2% mujeres), con edades comprendidas entre los 13 a 24 años (M = 17, DE = 2.93) pertenecientes a escuelas (62.2%) o universidades privadas (33.8%). Se analizó la estructura interna de la ERA-RSI, la invarianza según nivel educativo y sexo, su relación con otras variables y la confiabilidad por consistencia interna. Los resultados del Análisis Factorial Confirmatorio (AFC) indican una estructura de cuatro dimensiones con adecuados índices de ajuste (χ2 / gl = 3.81, CFI = .91, TLI = .90, RMSEA = .061 [.058, .065], SRMR = .061) y que es invariante según el nivel educativo (escolares y universitarios) y el sexo (hombres y mujeres). Además, se evidencia una buena confiabilidad por consistencia interna (ω = .74 a .83). Por su parte, la validez convergente se realizó con el Cuestionario de Adicción a las Redes Sociales (ARS) y se encontró, entre las dimensiones de ambas pruebas, correlaciones positivas, estadísticamente significativas y de magnitud entre moderadas y fuertes. En conclusión, la presente adaptación de la ERA-RSI cuenta, en general, con adecuadas evidencias empíricas de validez y fiabilidad y puede ser usada en futuras investigaciones. Palabras clave: adicción a redes sociales; adicción a internet; ERA-RSI; adolescentes; propiedades psicométricas.
Serotonin 5-HT7 Receptor is A Biomarker Poor Prognostic Factor and Induces Proliferation of Triple Negative Breast Cancer Cells Through FOXM1
Authors: Cınar Venhar , Hamurcu Zuhal , Guler Ahsen , Nurdinov Nursultan , Ozpolat Bulent , Çınar Venhar
Published: March 2022

Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer and associated with poor prognosis and shorter survival due to significant genetic heterogeneity, drug resistance and lack of effective targeted therapeutics. Therefore, novel molecular targets and therapeutic strategies are needed to improve patient survival. Serotonin (5-hydroxytriptamine, 5-HT) has been shown to induce growth stimulatory effects in breast cancer. However, the molecular mechanisms by which 5-HT exerts its oncogenic effects in TNBC still are not well understood. In the present study, we demonstrated that 5-HT induces cell proliferation of TNBC cells and expression of 5-HT7 receptor and FOXM1 oncogenic transcription factor. We found that expression of 5-HT7 receptor is up-regulated in TNBC cells and higher 5-HT7 expression is associated with poor patient prognosis and shorter patient survival. Genetic and pharmacological inhibition of 5-HT7 by siRNA and metergoline, respectively, suppressed TNBC cell proliferation and FOXM1 and its downstream mediators, including eEF2-Kinase (eEF2K) and cyclin-D1. Overall, our findings suggest for the first time that the 5-HT7 receptor promotes FOXM1, eEF2K and cyclin D1 signaling to support TNBC cell proliferation, thus inhibition of 5-HT7/FOXM1 signaling may be used as a potential therapeutic strategy for targeting TNBC.
Application of Risk Scoring System in Intra-operative Cell Salvage Patients: A Retrospective Study Based on Multicenter Data
Authors: LYU BIN , Liu Xinghui , Chen Daijuan , Chen Meng , Gou Jinhai
Published: March 2022

Background: Intraoperative cell salvage (IOCS) is widely used in cesarean section, and this study applied use of multi-center big data of IOCS in cesarean section to establish a bleeding risk assessment scale for IOCS patients. The purpose of this retrospective study was to explore the safety, health economy, and application guidelines of IOCS in obstetrics. Methods: We included 2621 patients who received IOCS technology during cesarean section in 12 hospitals between January 2012 - January 2020. The patients were divided into two groups, Group A, intraoperative blood loss <1500 ml; Group B, intraoperative blood loss ≥1500 ml. The clinical and imaging data associated with the risk of bleeding in patients taking IOCS were collected, and multivariable logistic regression analysis was conducted to develop a scoring system. Results: All patients who received IOCS in our study had no serious adverse outcomes. For the 2621 patients who take IOCS technology, while 407 cases not perform the blood transfusion, resulting in a waste rate of 15.5% for the resource. Multivariate logistic regression analysis was performed by selecting significant indicators from the univariate analysis and high-risk factors related to bleeding. The variables were maternal age ≥35 years, number of cesarean sections, placental attachment position, and placenta previa, each scored 1 point; placenta accreta, blood pool in the placenta, abnormal retroplacental myometrium, placenta protruding to the anterior uterine wall and continuous disruption of the myometrium, each scored 2 points; and cervical canal invasion, scored 4 points. All were risk factors for intraoperative blood loss volume ≥1500 ml in IOCS patients. A bleeding risk scoring system was constructed according to the above indicators. The area under the curve of the receiver operating characteristic curve (AUC) of the scoring system was 0.837, and a total score of 5 points was identified as the optimal cut-off value, allowing good differentiation of intraoperative massive bleeding in IOCS patients (AUC, 0.837; 95% confidence interval, 0.820–0.854), along with a sensitivity of 81.2% and specificity of 75.3%.Conclusion: IOCS technology is a safe and effective measure to solve the problem of clinical blood source shortages in obstetric cesarean section. Moreover, the bleeding risk scoring system could better guide the clinical application of IOCS technology. Therefore, strictly mastering the clinical application guidelines of IOCS can save medical resources and reduce the economic burden on patients.
AYA ‘Can-Sleep’ Program : protocol for a stepped-care, cognitive behavioral therapy based approach to the management of sleep difficulties in adolescents and young adults with cancer
Authors: Vaughan Emma Marie , Ftanou Maria , Lewin Jeremy , Murnane Andrew , Berger Ilana , Wiley Josh F , Hickey Martha , Bullen Dani , Jefford Michael , Goldin Jeremy , Stonehouse Jeremy , Thompson Kate
Published: March 2022

Background
Sleep problems are reported in up to 50% of adolescents and young adults (AYA) with cancer. Cognitive Behaviour Therapy for insomnia (CBTi) is considered the gold-standard treatment. In the AYA population, CBTi is associated with improvements in insomnia, daytime sleepiness, fatigue and quality of life. In adults, stepped care interventions can improve accessibility to CBTi. This study aims to evaluate the acceptability and feasibility of a stepped care CBTi program in AYA with cancer.
Methods and analysis
: AYA (target N=80) will be screened using the Insomnia Severity Index (ISI) and Epworth Sleepiness Scale (ESS). When sleep difficulties are identified by the ISI and/or ESS, they will be screened for obstructive sleep apnoea and restless leg syndrome and referred as indicated. The remainder will be offered a stepped care sleep program including CBT self-management and coaching (first step). Participants will then be re-screened at 5 weeks, and those with ongoing sleep difficulties will be offered individualised CBT (second step). Recruitment and retention rates, adherence to intervention, and time taken to deliver screening and intervention will be collected to assess the feasibility of the program. AYA and clinicians will complete evaluation surveys to assess the acceptability of the AYA Can-Sleep Program.
Discussion
We seek to contribute to the evidence-base regarding screening and treatment of sleep difficulties in the AYA population by implementing the AYA Can-Sleep program and determining its feasibility and acceptability as an approach to care in an Adolescent & Young Adult Cancer Service.
A Transition of Care Model from Hospital to Community for Hispanic/Latino Adult Patients with Diabetes: Design and Rationale for a Pilot Study
Authors: Corsino Leonor , Padilla Blanca Iris
Published: March 2022

Background: The Hispanic/ Latino population are disproportionately affected and have a higher risk of developing diabetes than their non-Hispanic White counterparts and worse diabetes-related outcomes. Diabetes continues to be an economic burden. This economic burden is partially due to the significantly higher rates of hospital readmission for individuals with diabetes. People with diabetes, particularly those who are members of racial/ethnic minority groups are at higher risk for readmission and emergency department (ED) visits. Despite recommendations regarding transition of care, an optimal approach to the transition of care for ethnic/minority patients remains unclear. Methods: The study population includes self- Identified Hispanic/Latino adults with diabetes. We have two aims: 1) designed and developed a transition of care model and 2) pilot test the newly developed transition of care model. For aim 1, semi-structures interviews conducted with patients and providers. For aim 2, patients admitted to the hospital enrolled to receive the newly designed transition of care model. For aim 1, patients and providers completed a short questionnaire. For aim 2, patients completed a set of questionnaires including demographic information, medical history, sociocultural and social support. The primary outcomes for aim 2 are readmission and emergency department visit within 30 days post discharge. Feasibility outcomes include number of participants identified, number of patients enrolled, number of participants who completed all the questionnaires, number of participants with a 30-day follow up call, and number of participants who completed the 30-day post-discharge questionnaire. Due to the COVID-19 pandemic the study design was adapted to include the Plan-Do-Study-Act framework to adjust to the ongoing changes in transition of care due to the pandemic burden on the health care systems. Conclusion: Transition of care for Hispanic/Latino patients with diabetes remains a major area of interest that requires further research. The pandemic required that we adapted the study to reflect the realities of health care systems during a time of crisis. The methods share in this manuscript can potentially help other investigators as they designed their studies. Trial registration: ClinicalTrials.gov identifier NCT04864639. 4/29/2021. https://clinicaltrials.gov/ct2/show/NCT04864639
Organ At Risk (OAR) Data on Clinical Toxicity in The Treatment of Bulky Adrenal Metastases With Stereotactic Ablative Radiotherapy (SABR)
Authors: Berber Tanju , Gürsel Özge Kandemir , Yıldırım Berna Akkuş , Erken Aysun Arslantaş , Dinçer Selvi Tabak , Gürdal Necla
Published: March 2022

Aim
Effectiveness of the treatment was investigated in terms of treatment responses and side effects with OAR in oligometastatic patients whose adrenal metastases were treated with SABR.
Methods
Patients who underwent radiosurgery for adrenal gland metastasis in our clinic were evaluated retrospectively for the patient, tumor, treatment characteristics, survival outcomes, and dosimetric parameters with toxicity.
Results
Of the 22 patients in our study. The primary tumor site was the lung in 20 (90.9%) of 22 patients, while ten (45.5%) of the patients had isolated adrenal metastasis. The median dose was 30 Gy (R:18–50) with a median fraction of five (R:3–10). The median PTV volume was 55 cc. (IQR:44-120cc). From the first diagnosis to adrenal gland radiotherapy, the median time was 6.9 months. The median follow-up was 7 months (R:2–48), and the median survival was 9.5 months (R:2–48). The local control rate was 72.7% in the 6th month, 63.6% in the 1st year, and 59.0% in the 2nd year, and overall survival was 72.7%, 50%, and 31.8%, respectively. The median overall survival was 9.5 months for all patients (p = 0.049) and 6.5 months in the presence of diffuse disease. Deaths of patients due to distant progression were also found to be significant (p = 0.03). Patients with isolated adrenal metastasis survived for 14.4 months after the treatment; while extra-adrenal metastasis lived for a median of 6.6 months (P = 0.01).
Conclusion
SABR in patients with oligometastatic adrenal disease not only provides symptom control but may also provide prolonged survival with minimal toxicity.
Identification of Candida Sp. In the Oral Cavity of the Sumatran Elephant (Elephas Maximus Sumatranus)
Authors: Erina Erina , Velayati Abdul Jabbar , Sayuti Arman , Dewi Maryulia , AK M Daud
Published: March 2022

Sumatran elephants are categorized as large mammals with critically endangered conservation status established by the International Union for Conservation of Nature and Natural Resources (IUCN). This research was conducted to identify Candida sp. in the oral cavity of the Sumatran elephant. The study was conducted based on the Odds and Bernaerts method. Swab sample of the elephant's oral cavity was observed after it was planted on CAC media and incubated for 48 hours at 37°C. The identification was carried out based on macroscopic observations of the differences in color of the Candida sp. Observation results showed that in the oral cavity of sumatran elephants can be overgrown with Candida albicans (100%), Candida tropicalis (100%), Candida parapsilosis (25%), Candida glabrata (25%) and other Candida (50%). It can be concluded that 4 types of Candida can be identified in oral cavity of sumatran elephant.
Persistent Colonisation of Antimicrobial Silver-Impregnated Shower Heads and Hoses Presents A Risk for Acquisition of Pseudomonas Aeruginosa in Healthcare Settings
Authors: Yetiş Özge , Ali Shanom , Karia Kush , Bassett Paul , Wilson Peter
Published: March 2022

Pseudomonas aeruginosa in healthcare waters presents an infection-risk to immune-suppressed patients. We introduced interventions (quarterly antimicrobial silver-impregnated shower head-hose replacement and shower-hose truncation) to determine effect on presence/persistence of P. aeruginosa in hospital shower-waters and drains over a seven-month survey (560 samples; 14 time-points) on augmented-care (immune-compromised) and non-augmented (general) wards. P. aeruginosa occurrence in the shower or drain predisposed to colonisation of the adjacent site/outlet (chi-square; p<0.001). Up to 80% of shower-waters/drains (augmented-care) were heavily-contaminated (>300CFU) before intervention and persisted despite remediation (P>0.05). Conversely, for every week elapsed, P. aeruginosa in the non-augmented wards increased by ~18% (P<0.001) in shower waters (OR=1.19; CI=1.09-1.31) and drains (OR=1.18; CI=1.09-1.30).Imipenem (showers), and aztreonam/ciprofloxacin-resistance (drains) occurred in up to 75% of sites in augmented-care with cefepime-resistance expressed in the general wards. Resistance-phenotypes declined after remediation despite ciprofloxacin being the only antimicrobial agent prescribed during this period.The shower environment in non-augmented care settings represents unrecognised reservoirs of P. aeruginosa. Once P. aeruginosa-bioburden is established, antimicrobial shower/hose materials and shortening of hoses are ineffective options for remediation. Efficacy-validation of antimicrobial materials and prevention of cross-contamination of the shower environment, plumbing and control-valves is essential to minimise acquisition of P. aeruginosa by vulnerable patients.
Safety and Tolerance Assessment of Milk Fat Globule Membrane-enriched Infant Formulas in Healthy Term Chinese Infants: A Randomised Multicenter Controlled Trial
Authors: Jiang BoWen , Xia Yong , Zhou LiHong , Liang Xiaoying , Chen XuHui , Chen Meizhen , Li Xiaoxia , Lin Shan , Zhang Nai , Zheng Ling , Tao Miao , Petocz Peter , Gallier Sophie , Rowan Angela , Wang Bing
Published: March 2022

Background: Milk fat globule membrane (MFGM), natural to breast milk, is essential for neonatal development, but lacking from standard infant formulas Objectives: To evaluate the safety and tolerability of MFGM supplementation in formula for infants 0 to 12 months. Methods: In a prospective, multicentre, double-blind, randomized trial, healthy term infants were randomized to a standard formula (SF, n = 104) or an MFGM-enriched formula (MF, n = 108) for 6 months and a corresponding follow-on formula until 12 months. Exclusively breast-fed infants (n = 206) were recruited as the reference group (BFR). Tolerance and safety events were recorded continuously. Anthropometric measurements were assessed at enrolment, 42 days and 4, 6, 8 and 12 months. Results: Infants (n=375) completed the study with average dropout of < 20%. Stool frequency, color, and consistency between SF and MF were not significantly different throughout, except the incidence of loose stools in MF at 6 months being lower than for SF (odds ratio 0.216, P < 0.05) and the frequency of green-colored stools at 12 months being higher in MF (CI 95%, odds ratio 8.92, P < 0.05). The BFR had a higher frequency of golden stools and lower rate of green stools (4-6 months) than the two formula-fed groups (P < 0.05). SF displayed more diarrhoea (4.8%) than MF (1%) and BFR (1%) at the 8-month visit (P < 0.05). BFR (0-1%) had significantly less (P < 0.05) lower respiratory infections than MF (4.6-6.5%) and SF (2.9-5.8%) at 6- and 8-months, respectively. Formula intake, frequency of spit-up/vomiting or poor sleep were similar between SF and MF. Growth rate (g/day) was similar at 4, 6, 8 and 12 months between the 3 groups, but growth rate for BFR was significantly higher than for SF and MF at 42 days (95% CI, P = 0.001).Conclusions: MFGM-enriched formula was safe and well-tolerated in healthy term infants between 0 and 12 months, and total incidences of adverse events were similar to that for the SF group. A few differences in formula tolerance were observed, however these differences were not in any way related to poor growth.
A pilot, feasibility randomised, controlled trial comparing walking exercise against pendulum leg swinging exercise in adults with osteoarthritis of the knee.
Authors: Huang Lixia , Xia Zhidao , Esser Patrick , Dawes Helen , Wade Derick , Song Jiuhong
Published: March 2022

Background.In China, swinging the leg backwards and forwards is a commonly used therapy for people with osteoarthritis of the knee. One rationale is that movement without weightbearing may increase the range of movement by allowing a greater range of pian-free movement at the knee. There have been no studies evaluating its effectiveness. Before undertaking a large trial, a pilot study is needed to establish feasibility and an estimate of the sample size needed.Methods.This will be a parallel-group, assessor-masked, randomised, controlled study comparing the effect of pendulum leg swinging against an equivalent time of walking exercise. Patients will be recruited from the outpatient and inpatient orthopaedic surgery services in a large, class III general hospital in Wuhan, China. To be selected they must have clinically diagnosed osteoarthritis of the knee. Patients will be excluded if they have additional knee disease, have had hip or knee arthroplasty or a tibial osteotomy, are taking steroids or have done so in the preceding three months, have another illness affecting mobility or participation in the study, are pregnant, or have a body mass index (BMI) over 36. They will be allocated randomly using sealed, prefilled envelopes on a 1:1 basis. Data will be collected by masked observers at baseline and 12 weeks. Measures include the Oxford Knee Score, the six-minute walking distance, pain measured on a numerical rating scale, the 30 second sit-to-stand test, quadriceps muscle strength, and accelerometer data. Feasibility data will record data-completion rates, recruitment and retention rates, adherence with treatment, and patient experience including adverse events. The two interventions will involve a gradual increase of exercise between baseline and 6 weeks with a further six weeks at the level set for each patient. Data analysis will be descriptive, with comparative analysis on outcome measures to give an estimate of sample size needed in a full trial.Discussion.Swinging the leg like a pendulum combines exercise and movement of the knee without bearing weight. Exercise is known to give some benefit but it is not known whether joint movement without weight-baring has any beneficial effect. A large trial would be needed. This trial will establish how feasible it might be to undertake a large trial.Trial registration details.Registry: Chinese Clinical Trial RegistryNumber: ChiCTR2100051275Date: 17th September 2021URL: https://www.chictr.org.cn/historyversionpuben.aspx?regno=ChiCTR2100051275