bluuebunny/crossref_metadata_2025 huggingface dataset:
Construction and analysis of a ceRNA network and patterns of immune infiltration in chronic rhinosinusitis with nasal polyps: based on data mining and experimental verification
Authors: Chen Jing-cai , Xing Qi-long , Yang Hui-wen , Yang Fan , Luo Yao , Kong Wei-jia , Wang Yan-jun
Published: June 2022

Recent studies have revealed the significant role of the competing endogenous RNA (ceRNA) network in human diseases. However, systematic analysis of the ceRNA mechanism in chronic rhinosinusitis with nasal polyps (CRSwNP) is limited. In this study, we constructed a competitive endogenous RNA (ceRNA) network and identified a potential regulatory axis in CRSwNP based on bioinformatics analysis and experimental verification. We obtained lncRNA, miRNA, and mRNA expression profiles from the Gene Expression Omnibus. After analysis of CRSwNP patients and the control groups, we identified 565 DE-lncRNAs, 23 DE-miRNAs, and 1799 DE-mRNAs by the DESeq2 R package or limma R package. Enrichment analysis of 1799 DE-mRNAs showed that CRSwNP was associated with inflammation and immunity. Moreover, we identified 21 lncRNAs, 8 miRNAs and 8 mRNAs to construct the lncRNA-miRNA-mRNA ceRNA network. A potential MIAT/miR-125a/IRF4 axis was determined according to the degree and positive correlation between a lncRNA and its competitive endogenous mRNAs. The GSEA results suggested that IRF4 may be involved in immune cell infiltration. The validation of another dataset confirmed that MIAT and IRF4 were differentially expressed between the CRSwNP and control groups. The area under the ROC curve (AUC) of MIAT and IRF4 was 0.944. The CIBERSORT analysis revealed that eosinophils and M2 macrophages may be involved in the CRSwNP process. MIAT was correlated with dendritic cells and M2 macrophages, and IRF4 was correlated with dendritic cells. Finally, to validate the key genes, we performed in-silico validation using another dataset and experimental validation using immunohistochemistry, immunofluorescence, and Western blot. In summary, the constructed novel MIAT/miR-125a/IRF4 axis may play a critical role in the development and progression of CRSwNP. We believe that the ceRNA network and immune cell infiltration could offer further insight into novel molecular therapeutic targets for CRSwNP.
Digital body mapping of pain quality and distribution in athletes with longstanding groin pain
Authors: Serner Andreas , Reboul Gilles , Lichau Olivier , Weir Adam , Heijboer Willem , Vuckovic Zarko , Boudreau Shellie Ann
Published: June 2022

Groin pain is common in athletes, but remains a challenge to diagnose. Self-reported pain quality distribution may facilitate differential diagnoses. We included 167 athletes with groin pain (≥ 4 weeks). All athletes received a standardized clinical examination. Athletes could choose multiple quality descriptors and intensity, and drew these on a digital body map. Overlay images were created to assess distribution and area visually. Intensity, duration, and qualities were compared between each clinical entity and multiple entities. Top three quality descriptors were electric (22%), pain (19%), and dull/aching (15%). There were no differences in the frequencies of quality descriptors (p = 0.893) between clinical entities. Areas of the mapped qualities were similar between the single clinical entities (χ2(3) = 0.143, p = 0.986) and independent of symptom duration (ρ = 0.004, p = 0.958). Despite a considerable overlap, the mapped pain qualities’ distributions appear to differ visually between single clinical entities and align with the defined clinical entities of adductor-related, inguinal-related, and pubic-related groin. In iliopsoas-related groin pain, pain extended more medially. The overlap between the drawn areas underscores a challenge in differentiating groin pain classifications based only on self-reported pain. The prevalence of pain quality descriptors varied and individually do not associate with one particular clinical entity of groin pain.
Interannual fluctuations in connectivity among crab populations (Liocarcinus depurator) along the Atlantic-Mediterranean transition
Authors: Ojeda Víctor , Serra Bruna , Lagares Clàudia , Rojo-Francàs Eva , Sellés Maria , Marco-Herrero Elena , García Encarnación , Farré Marc , Arenas Concepció , Abelló Pere , Mestres Francesc
Published: June 2022

An interesting evolutionary question that still remains open is the connectivity between marine populations. Marine currents can favour the dispersal of larvae or adults, but they can also produce eddies and gyres generating oceanographic fronts, thus limiting gene flow. To address this subject, we selected the Atlantic-Mediterranean transition, where several fronts are located: Gibraltar Strait (GS), Almeria-Oran Front (AOF) and Ibiza Channel (IC). Seven populations of the marine crab Liocarcinus depurator (Cadiz, West and East Alboran, Alacant, Valencia, Ebro Delta and North Catalonia) located along this transition were analysed in six consecutive years (2014–2019) using a fragment of the COI (Cytochrome Oxidase subunit I) gene. All sequences (966) belonged to two well defined haplogroups: ATL (most abundant in Atlantic waters) and MED (predominant in Mediterranean waters). Following a geographic variation, the frequency of ATL decreased significantly from Cadiz to North Catalonia. However, this variation presented steps due to the effect of oceanographic restrictions/fronts. Significant effects were recorded for GS (2015, 2017, 2018 and 2019), AOF (all years except 2018) and IC (2016). The intensity and precise location of these fronts changed over time. Multivariate analyses distinguished three main population groups: Cadiz, Alboran Sea and the remaining Mediterranean populations. These findings could be relevant to properly define Marine Protected Areas and for conservation and fisheries policies.
Differences in stress response between two altitudes assessed by salivary cortisol levels within circadian rhythms in long-distance runners
Authors: Tsunekawa Katsuhiko , Ushiki Kazumi , Martha Larasati , Nakazawa Asuka , Hasegawa Rika , Shimizu Risa , Shimoda Nozomi , Yoshida Akihiro , Nakajima Kiyomi , Kimura Takao , Murakami Masami
Published: June 2022

There are conflicting reports regarding the efficacy of cortisol as a stress marker in altitude training due to the influence of the circadian rhythm. This study aimed to verify whether the automated measurement of salivary cortisol concentration via sequential sampling could detect the differences in exercise stress between two altitudes. We enrolled 12 elite female long-distance runners living near sea level. For the first higher-altitude camp, the runners lived at 1800 m and trained at 1700 m for 7 days. For the second lower-altitude camp, they lived at 1550 m and trained at 1300 m for 7 days. Their saliva was sequentially collected on the last 2 days during each camp which involved different intensity exercises in the morning and afternoon. The salivary cortisol concentrations were measured using electrochemiluminescence immunoassay. Before dinner, the basal salivary cortisol concentrations were significantly higher in the higher-altitude camp. The rate of change in the salivary cortisol concentration during the morning exercise was significantly higher in the higher-altitude camp than in lower-altitude camp (p = 0.028) despite the same exercise programs and intensities. Salivary cortisol level measurements during the athletes' circadian rhythms could detect the differences in acclimatization and exercise stress between two altitudes.
The relationship between ocular and oral dryness in a cohort from the 65-year-old population in Norway
Authors: Hynne Håvard , Tashbayev Behzod , Diep My Tien , Sødal Anne Thea Tveit , Badian Reza A. , Chen Xiangjun , Lai Xiaoran , Utheim Tor P. , Hove Lene Hystad , Jensen Janicke Liaaen
Published: June 2022

In the present study, the relationship between dry eyes and dry mouth was explored in 150 65-year-old subjects randomly selected from the general population in Oslo, Norway. The number of drugs, including xerogenic drugs, and current and previous systemic diseases were recorded. Ocular parameters recorded were the McMonnies Dry Eye Questionnaire, the Ocular Surface Disease Index, the Schirmer I Test, tear film break-up time and ocular surface staining. The oral parameters were xerostomia frequency, Summated Xerostomia Inventory, Clinical Oral Dryness Score, and unstimulated and stimulated whole saliva. The participants with current or previous systemic diseases had significantly more ocular and oral symptoms and significantly more oral clinical findings than the participants without a history of disease. Moreover, correlation and factor analyses demonstrated an association between subjective ocular and oral parameters. A significant correlation between the total number of drugs and the presence of ocular and oral symptoms was also noted. When the participants were categorized based on their ocular symptoms, poorer values were found for the oral parameters among the participants more troubled with dry eyes. The results in the present study call for increased awareness and an interdisciplinary approach in matters related to dry eyes and dry mouth.
Dietary supplements do not improve bone morphology or mechanical properties in young female C57BL/6 mice
Authors: Creecy Amy , Smith Collier , Wallace Joseph M.
Published: June 2022

Bone is a hierarchical material formed by an organic extracellular matrix and mineral where each component and their physical relationship with each other contribute to fracture resistance. Bone quality can be affected by nutrition, and dietary supplements that are marketed to improve overall health may improve the fracture resistance of bone. To test this, 11 week old female C57BL/6 mice were fed either collagen, chondroitin sulfate, glucosamine sulfate, or fish oil 5 times a week for 8 weeks. Femurs, tibiae, and vertebrae were scanned with micro-computed tomography and then mechanically tested. Glucosamine and fish oil lowered elastic modulus, but did not alter the overall strength of the femur. There were no differences in bone mechanics of the tibiae or vertebrae. Overall, the data suggest that dietary supplements did little to improve bone quality in young, healthy mice. These supplements may be more effective in diseased or aged mice.
Ultrathin Al–air batteries by reducing the thickness of solid electrolyte using aerosol jet printing
Authors: Zuo Yuxin , Yu Ying , Feng Junyan , Zuo Chuncheng
Published: June 2022

Flexible Al–air batteries have great potential in the field of wearable electronic devices. However, how to reduce the thickness of the battery and improve their applicability in wearable applications is still an unresolved thorny problem. Therefore, this article focuses on the strategies to minimize the thickness of the solid electrolyte for flexible Al–air batteries. In this paper, an innovative aerosol jet printing method is used to prepare the ultrathin neutral electrolyte with a thickness of 18.3–74.5 μm. This study discusses the influence of the thickness and ion concentration on the conductance of the electrolyte in detail. The ultrathin electrolyte has been applied to the flexible Al–air battery, and the battery performance has been explored. The cell pack composed of single cells is light and thin, and can successfully drive small electrical equipment. This study provided new ideas for the preparation of ultrathin electrolyte for flexible energy products.
An Ag2S@ZIF-Van nanosystem for NIR-II imaging of bacterial-induced inflammation and treatment of wound bacterial infection
Authors: Huang Yao , Geng Hongchao , Wu Zeming , Sun Leilei , Ji Chenhui , Grimes Craig A. , Feng Xinxin , Cai Qingyun
Published: June 2022

Bacterial diseases pose a serious threat to human health. Continued development of precise diagnostic methods and synergistic therapy techniques for combating bacteria are needed.
Mechanistic kinetic modeling for catalytic conversion of DME to gasoline-range hydrocarbons over nanostructured ZSM-5
Authors: Lee Damin , Kim Jong Jin , Ali Mansoor , Choung Jin Woo , Lee Won Bo , Bae Jong Wook , Park Myung-June
Published: June 2022

A new kinetic model for the synthesis of gasoline-range hydrocarbons from dimethyl ether over a nanostructured ZSM-5 catalyst was developed based on the dual-cycle reaction mechanism.
Beneficial effects of psyllium on the prevention and treatment of cardiometabolic diseases
Authors: Chen Chen , Shang Chang , Xin Laiyun , Xiang Mi , Wang Yuling , Shen Zihuan , Jiao Linke , Ding Fan , Cui Xiangning
Published: June 2022

Psyllium, especially its husk, has been widely used in food products. This review summarized the potential mechanisms of it in the prevention and treatment of cardiometabolic diseases and its applications in food systems.
Isolation and characterization of auronlignan derivatives with hepatoprotective and hypolipidemic activities from the fruits of Hippophae rhamnoides L.
Authors: Ma Qinge , Guan Yang , Sang Zhipei , Dong Jianghong , Wei Rongrui
Published: June 2022

The fruit of Hippophae rhamnoides L. is not only used as delicious food with nutritional values, but also served as traditional Chinese medicine with multiple bioactivities.
Stimuli-responsive and core cross-linked micelles developed by NiCCo-PISA of helical poly(aryl isocyanide)s
Authors: Jimaja Sètuhn , Varlas Spyridon , Foster Jeffrey C. , Taton Daniel , Dove Andrew P. , O'Reilly Rachel K.
Published: June 2022

Spherical micelles with a helical core synthesised by NiCCo-PISA are functionalised with different cross-linkers to make stimulus-sensitive nanostructures.
Ru@Ni3S2 nanorod arrays as highly efficient electrocatalysts for the alkaline hydrogen evolution reaction
Authors: Wang Kefeng , Li Bin , Ren Jingxiao , Chen Wenxia , Cui Jinhai , Wei Wei , Qu Peng
Published: June 2022

Ru-decorated Ni3S2 nanorod arrays demonstrate an superior alkaline hydrogen evolution performance. Further modification with polyaniline could significantly enhance the long-term stability for continuous hydrogen generation.
Synthesis of CoSe2 reinforced nitrogen-doped carbon composites as advanced anodes for potassium-ion batteries
Authors: Yang Guowei , Yan Chengzhan , Hu Ping , Fu Qun , Zhao Huaping , Lei Yong
Published: June 2022

Owing to the synergistic effect of CoSe2 and N-doped carbon matrix, a composite of CoSe2 nanoparticles dispersed in polydopamine-derived N-doped carbon matrix exhibits high specific capacity and excellent cyclability as potassium-ion battery anode.
Antifluorite-type Na5FeO4 as a low-cost, environment-friendly cathode with combined cationic/anionic redox activity for sodium ion batteries: a first-principles investigation
Authors: Thøgersen Rasmus Vester , Bianchini Federico , Fjellvåg Helmer , Vajeeston Ponniah
Published: June 2022

Fukui-functions calculated for predicted phases upon desodiation of potential cathode material Na5FeO4, to Na3.5FeO4, showing predicted simultaneous redox activity associated with Fe and O electronic states.
Innovative electrochemical electrode modified with Al2O3nanoparticle decorated MWCNTs for ultra-trace determination of tamsulosin and solifenacin in human plasma and urine samples and their pharmaceutical dosage form
Authors: Attia Khalid A. M. , Abdel-Raoof Ahmed M. , Serag Ahmed , Eid Sherif M. , Abbas Ahmed E.
Published: June 2022

A SWV method using a carbon paste electrode modified with aluminum oxide nanoparticle-decorated multi-walled carbon nanoparticles is presented for ultra-sensitive determination of tamsulosin and solifenacin, one of the most prescribed pharmaceutical combinations in urology.
Synthesis and photophysical properties of photostable 1,8-naphthalimide dyes incorporating benzotriazole-based UV absorbers
Authors: Uesaka Toshiyuki , Ishitani Tomoyuki , Shimeno Takahito , Suzuki Naoya , Yagi Shigeyuki , Maeda Takeshi
Published: June 2022

Highly photostable blue fluorescence dyes were developed by hybridization of 1,8-naphthalimides with benzotriazole-based UV absorbers enabling a non-radiative energy dissipation process of excited-state intramolecular proton transfer (ESIPT).
Highly sensitive and convenient aptasensor based on Au NPs@Ce-TpBpy COF for quantitative determination of zearalenone
Authors: Chen Zhixiong , Yang Meng , Li Ziying , Liao Wenchun , Chen Bengqi , Yang Tong , Hu Rong , Yang Yunhui , Meng Shuang
Published: June 2022

An aptasensor based on a portable U-disk electrochemical workstation is demonstrated for the quantitative determination of zearalenone. The aptamer sensor exhibited excellent sensitivity, selectivity, reproducibility.
Effects of Ti-doping amount and annealing temperature on electrochromic performance of sol–gel derived WO3
Authors: Park Hee Sung , Park Sunghyeok , Song Seung Han , Dao Thuy Thi , Tran Hung Van , Lee Seok In , Han Chi-Hwan , Cho Churl Hee , Hong Sungjun
Published: June 2022

Fine-control of structural properties of WO3. Faster and balanced charge transfer kinetics. Higher coloration efficiency.
Evaluation of Nd0.8−xSr0.2CaxCoO3−δ(x = 0, 0.05, 0.1, 0.15, 0.2) as a cathode material for intermediate-temperature solid oxide fuel cells
Authors: Du Xu , Li Songbo , An Shengli , Xue Liangmei , Ni Yang
Published: June 2022

The increase in Ca for Nd0.8−xSr0.2CaxCoO3−δ limits the electronic compensation capacity, resulting in a decrease in CTE. The Ca-doped material maintains good electrochemical properties under CTE reduction and thus can be used as an IT-SOFC cathode.
Tracing the geographic origin of velvet antlers in China via stable isotope analyses
Authors: Zhao Haiping , Zhang Guokun , Wang Dongxu , Liu Zhen , Chen Rui , Zhang Wei , Li Chunyi
Published: June 2022

Multielement (H, C, N, O) stable isotope ratio analysis was used to discriminate the geographical origin of velvet antlers (VAs) of deer from ten provinces in China.
Visible-light-induced one-pot synthesis of sulfonic esters via multicomponent reaction of arylazo sulfones and alcohols
Authors: Luu Truong Giang , Bui Tien Tan , Kim Hee-Kwon
Published: June 2022

Facile and efficient one-pot synthesis of sulfonic esters has been achieved via visible-light-induced multicomponent reaction of arylazo sulfones, and alcohols in the presence of DABSO, CuI, and HCI.
Simple, rapid, and visual electrochemiluminescence sensor for on-site catechol analysis
Authors: Chen Suhua , Lei Yuanyuan , Xu Junrong , Yang Yun , Dong Yiying , Li Yanmei , Yi Haomin , Liao Yilong , Chen Liyin , Xiao Yi
Published: June 2022

A simple, rapid and visual mesoporous silica (MSNs)-electrochemiluminescence (ECL) sensor was developed for on-site monitoring of Cat.
Automated passive serial dilution microfluidic chip for calcium quantification based on the Arsenazo III method
Authors: Tazin Nusrat , Patel Dhruv , Lambert Christopher Jordon , M. Shad Mohammad H. , Campbell Jeff , Gale Bruce K.
Published: June 2022

A schematic of the resistive-circuit method with three inlets for DI water, reagent and urine sample. The mixed fluids are transferred to a detection chamber.
On-chip integrated graphene aptasensor with portable readout for fast and label-free COVID-19 detection in virus transport medium
Authors: Xu Lizhou , Ramadan Sami , Rosa Bruno Gil , Zhang Yuanzhou , Yin Tianyi , Torres Elias , Shaforost Olena , Panagiotopoulos Apostolos , Li Bing , Kerherve Gwilherm , Kim Dong Kuk , Mattevi Cecilia , Jiao Long R. , Petrov Peter K. , Klein Norbert
Published: June 2022

On-chip integrated graphene field-effect transistor (GFET)-based aptasensor was developed with portable readouts for sensitive and specific virus detection.
Improving the electron transfer in the oxygen reduction reaction by N/S co-doping for high-performance of Zn–air batteries
Authors: Wei Jiawei , Li Ping , Shi Jing , Huang Minghua , Tian Weiqian , Wang Huanlei
Published: June 2022

The carbonization product of κ-carrageenan can fix melamine for introducing N doping, which can facilitate the four-electron transfer path, resulting in the fabrication of high-performance Zn–air batteries.
Low-temperature resistant gel polymer electrolytes for zinc–air batteries
Authors: Wu Jiao , Wang Yuchao , Deng Danni , Bai Yu , Liu Mengjie , Zhao Xin , Xiong Xiang , Lei Yongpeng
Published: June 2022

The rapid development of wearable devices has put forward high requirements for stable, solid-state, flexible and even stretchable energy storage systems.
Biomimetic FeCo@PDA nanozyme platform with Fenton catalytic activity as efficient antibacterial agent
Authors: Kuang Fei , Chen Yingjie , Shan Wei , Li Yonghai , Bao Xichang , Gao Xiang , An Dong , Qiu Meng
Published: June 2022

Biomimetic bi-metal polydopamine nanospheres (FeCo@PDA NPs) with strong adhesion and catalytic Fenton reactive enzyme activity can significantly kill Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) by destroyed the bacterial membrane structure and produce ROS.
Piezoelectricity and related properties in orthorhombic cadmium diiodate
Authors: Azeroual H. , Bantignies J.-L. , Alvarez L. , Maurin D. , Granier D. , Haines J. , Cambon O. , Hermet P.
Published: June 2022

We report a complete investigation of the structural, electronic, vibrational, elastic and piezoelectric properties of the P212121 orthorhombic phase in cadmium diiodate (δ-Cd(IO3)2) by combining experiments and first-principles based calculations.
3D MXenes as promising alternatives for potential electrocatalysis applications: opportunities and challenges
Authors: Rasheed Tahir
Published: June 2022

Since the invention of MXenes (Ti3C2Tx), they have been positioned as an emerging class of two-dimensional (2D) nanomaterials for energy conversion and storage applications.
Aluminum chloride assisted synthesis of near-unity emitting Mn2+-doped CsPbCl3 perovskite nanocrystals for bright white light-emitting diodes
Authors: Chen Mingyan , Cao Sheng , Xing Ke , Song Yusheng , Han Xinxin , Zeng Ruosheng , Zou Bingsuo , Zhao Jialong
Published: June 2022

Enhanced orange-red emitting Mn2+-doped CsPbCl3 nanocrystals with a near-unity photoluminescence quantum yield of up to 98% are synthesized through an AlCl3-assisted hot-injection route.
Schlaf, Kindlein, Schlaf…
Authors: Weber Patricia
Published: June 2022

Im Rahmen einer Studie wurde der Einfluss von Musik als Assessmentinstrument
für diagnostische und therapeutische Verfahren in der Endoskopie
untersucht. Hierbei wurde vor allem die Auswirkung auf den Gemütszustand
und die Vitalparameter der Patienten betrachtet. Durch analytische Mittel wurden
die Ergebnisse der Studie in Form von Tabellen und Diagrammen ausgewertet, um
Rückschlüsse auf den Erfolgsfaktor der musikalischen Anwendung
während einer Untersuchung zu rechtfertigen, und um dadurch einen festen
Einsatz von Musik in der Endoskopie zu etablieren.
Interprofessionelles Wissens- und Skillstraining der PEG-Anlage an
Simulatoren – Entwicklung und Testung eines nationalen Curriculums
für Ärzte und spezialisierte Pflegende
Authors: Engelke Monika , Grund Karl Ernst , Schilling Dieter , Beilenhoff Ulrike , Kern-Waechter Elisabeth , Engelke Olaf , Stebner Ferdinand , Kugler Christiane
Published: June 2022

Einleitung Ein Positionspapier verschiedener Fachgesellschaften zur
Delegation ärztlicher Tätigkeiten in der Gastroenterologie
fordert im Abschnitt „Perkutane Punktion bei der Anlage einer perkutanen
endoskopischen Gastrostomie (PEG)“ ein nationales Curriculum für
Trainingskurse, die vor der Durchführung der Punktion absolviert werden
sollen.

Gegenstand der vorliegenden Studie ist die Entwicklung und Testung eines solchen
Curriculums. Ziel ist die Vermittlung des notwendigen Wissens und der Skills zur
sicheren Durchführung der PEG-Anlage für Ärzte und
Pflegende.

Methoden Die Testung erfolgte im Rahmen einer nicht randomisierten,
interventionellen Pilotstudie an Simulatoren. Sie umfasste (1) eine
Vorbereitungsphase, (2) eine theoretische und (3) eine praktische Phase. Nach
der theoretischen Phase erfolgte eine Überprüfung der kognitiven
Fähigkeiten mittels Wissenstests. Am Ende der praktischen Phase wurde
das Anlageprozedere jedes einzelnen Teilnehmers mehrkanalig auf Video
aufgezeichnet und die sensomotorischen Fähigkeiten wurden mithilfe eines
Assessmentinstruments (AS-PEG) ausgewertet. Abschließend wurde eine
Evaluation mittels Fragebogen zur Zufriedenheit der Teilnehmenden
durchgeführt.

Ergebnisse Sieben Ärzte und 17 Pflegende absolvierten die im
Curriculum definierten Phasen und abschließenden Prüfungen. Beim
Wissenstest wurden durchschnittlich 70,3±3,7 (61–75) von 76
Punkten erreicht. Beim Test zu den erworbenen sensomotorischen
Fähigkeiten wurden durchschnittlich 37,1±2,1 (32–40) von
42 Punkten erzielt. Die Evaluation ergab eine hohe Zufriedenheit der
Teilnehmenden in Bezug auf Inhalte, Lernzielerreichung und erworbene praktische
Fähigkeiten.

Schlussfolgerung Eine Verbreitung des Curriculums wird als sinnvoll und
notwendig erachtet, um theoretische und praktische Kenntnisse für
Ärzte und Pflegende durch das strukturierte interprofessionelle Wissens-
und Skillstraining zu vermitteln und den Pflegenden einen rechtlich
abgesicherten Rahmen zu bieten.
The Relationship Between Baseline Cortisol Levels and Surgery Method
of Primary Bilateral Macronodular Adrenal Hyperplasia
Authors: Gao Jie , Yu Zhongwei , Sun Fukang , Xu Bilin , Zhang Cuiping , Wang Hongping , Lu Jun , Lei Tao
Published: June 2022

Aim was to explore the associations between baseline cortisol levels and surgery
method of primary bilateral macronodular adrenal hyperplasia (PBMAH). We
retrospectively reviewed the clinical features and management of 30 patients (18
females and 12 males) who were diagnosed with PBMAH in our center between 2005
and 2019. Based on surgery method, we divided the patients into two groups:
unilateral adrenalectomy (UA) group; and bilateral adrenalectomy (BA) group.
Serum cortisol rhythm and 24-hour urinary free cortisol
(UFC/24 h) levels were assayed using chemiluminescence method.
Associations between baseline cortisol levels and BA were assessed using
logistic regression. The predictive value of baseline cortisol levels for BA was
calculated using receiver operating characteristic (ROC) curves. Twenty patients
(66.7%) underwent UAs and ten patients (33.3%) underwent BAs.
After adjusting for age, sex, BMI, SBP, and adrenal volume, the concentrations
of baseline serum cortisol (8 AM, 4 PM, and 0 AM) and UFC/24 h
were associated with bilateral adrenalectomy (all p<0.05). The area
under the ROC curve based on 8 AM serum cortisol level model was larger than
that in models based on 4 PM, 0 AM serum cortisol levels and
UFC/24 h, but the differences were non-significant (all
p>0.05). According to maximum Youden index criteria, the optimal cutoffs
of 8 AM serum cortisol level and UFC were 26.89 μg/dl
and 406.65 μg/24 h, respectively, for BA. The
baseline cortisol levels are positively associated with BA. Increased levels of
baseline cortisol levels may predict higher possibility of BA, which should be
confirmed by prospective studies.
Cluttering in a School-Aged Child: Tackling the Challenges Step by Step
Authors: Scaler Scott Kathleen
Published: June 2022

The purpose of this article is to highlight and provide solutions for the complexities of the communication disorder of cluttering. The article includes a 12-part case study of a school-aged child who is referred for an evaluation due to decreased speech intelligibility. The case is woven throughout the article to illustrate all aspects of client management: initial referral, evaluation and differential diagnosis, treatment, and discharge. The case reflects the challenges of increasing client awareness and the importance of advocating for client's needs throughout the process. This article provides background on myths about cluttering and current research findings to debunk these myths. Additionally, methods for evaluation, differential diagnosis, and treatment of cluttering are presented. An indirect approach to increasing client awareness and family and client education is included. The overall focus is to help the clinician better understand how to evaluate, treat, discharge, and advocate for clients with cluttering in ways that meet clients where they are.
Raise Your Brow on a Missing Tooth from Dental Arch—How far CBCT is Helpful?
Authors: Kalra Geeta , Kalia Vimal , Suri Nikita , Sharma Prabhat , Kalra Tarun
Published: June 2022

The aim of this article is to discuss the sequelae of a missing tooth from normal series of dental arch and the importance of cone beam computed tomography (CBCT) in diagnosis and treatment planning in such cases. We also correlate the position of an impacted maxillary premolar as seen on panoramic radiography with CBCT. Routine imaging modalities like intraoral periapical, occlusal, and panoramic view often give inadequate information which can be misleading to the surgeon. Exact location of an impacted/missing tooth and its relation to dental and vital structures which was previously a challenge to assess by the clinician, can now be very well interpreted with CBCT. In this report, a case of impacted maxillary premolar is highlighted with its image on the panoramic radiograph, its exact location/position on CBCT, and how surgical removal was accomplished.
Septic Mycobacterium Avium Intracellulare Extensor Tenosynovitis of the Wrist
Authors: McDermott Daniel G. , Hill Samantha M. , Desai Kapil , Jaggessarsingh Dana , Vitale Mark A.
Published: June 2022

Mycobacterium avium intracellulare (MAI) infections of the hand, wrist, and upper extremity are rare, but potentially devastating atypical mycobacterial infections that can affect tendon, bone, and other soft tissues of the musculoskeletal system. We present an immunocompromised patient presenting with acute swelling and pain in the dorsum of the hand and wrist that underwent a wrist extensor tenosynovectomy with intraoperative cultures revealing infection with MAI. The patient developed severe progression of the infection with osteomyelitis of the distal forearm and carpal bones, multiple subsequent extensor tendon ruptures, and dorsal skin necrosis. The infection was eradicated with a combination of surgical treatment and antibiotic therapy. The case is discussed in context of the prior scant literature of infectious tenosynovitis of the hand, wrist, and upper extremity caused by MAI. This case report and literature review outline recommendations for diagnosis and effective treatment of MAI.
Enhancement of room-temperature magnetization in GaFeO3-type single crystals by Al and Sc doping
Authors: Wang Ling , Katayama Tsukasa , Wang Chaoyue , Li Qin , Shi Yun , Fang Yuqiang , Huang Fuqiang , Zhu Yinghao , Li Hai-feng , Yasui Shintaro , Huang Xintang , Yu Jianding
Published: June 2022

GaFeO3-type oxides are promising multiferroic materials due to the coexistence of spontaneous magnetization and ferroelectric polarization properties at room temperature. As these ferroic properties feature a large anisotropy, single crystals are required. However, the magnetization of GaFeO3-type single crystals remains low at room temperature. In this study, we largely enhanced the magnetization at room temperature of GaFeO3-type single crystals by increasing the Fe content and co-doping Sc3+ and Al3+. Single crystals of AlxSc0.1−xGa0.6Fe1.3O3 (x = 0.01–0.04) were prepared using the optical floating-zone method. The single crystals were rod-shaped, with a diameter and length of ∼6 mm and 7 cm, respectively. X-ray diffraction measurements confirmed the ferroelectric polarization of the crystals. In addition, they exhibited room-temperature ferrimagnetism, with Curie temperature in the range of 326–338 K; the crystals exhibit magnetic anisotropy along the a-axis. The magnetization of the single crystal at 300 K and 0.3 kOe was 13 emu g−1, which is over ten times larger than those of previously reported single crystals with GaFeO3-type crystal structure.
Non-classical hydrogen storage mechanisms other than chemisorption and physisorption
Authors: Liu Shiyuan , Liu Jieyuan , Liu Xiaofang , Shang Jia-Xiang , Yu Ronghai , Shui Jianglan
Published: June 2022

The hydrogen storage mechanism of materials is usually divided into chemisorption and physisorption according to the way the material interacts with hydrogen. Chemisorption refers to the breaking of hydrogen molecules into hydrogen atoms, which are then bonded to materials through chemical bonds. Physisorption refers to the adsorption of hydrogen molecules on the surface of materials with high specific surface areas through van der Waals forces. With the development of materials science and characterization techniques, some new hydrogen storage materials are emerging, which exhibit relatively complex interactions with hydrogen. This review will focus on non-classical hydrogen storage materials and mechanisms beyond physisorption and chemisorption, including Kubas interactions, nanopump effects, non-dissociative chemisorption, and weak-confined insertion of hydrides. This review will give researchers a clear view of the diversity of hydrogen storage materials and the complexity of hydrogen storage mechanisms, which may help enrich future hydrogen storage materials.
Linear stability analysis of convection in a solid partitioned inhomogeneous multilayered porous structure
Authors: Rathish Kumar B. V. , Pathak Parul
Published: June 2022

We investigate the effect of varying permeability on the onset of convection in a system of multi-layered porous medium when heated from below. Here, the interface between any two porous sublayers is a thick solid conducting plate. The porous sublayers are inhomogeneous with respect to their permeability. Results for the homogeneous case are validated against those from the literature. The solvability condition is produced for a general N– layered inhomogeneous system to study the neutral curves. Detailed results are presented for a two layered and a three layered configuration. The effect of the involved parameters such as permeability ratio, thermal conductivity ratio, and thickness ratio on the onset of convection is analyzed using linear stability analysis. The critical values of Rayleigh number and the corresponding wave number increased with the increase in the thermal conductivity of the solid partitions, irrespective of the change in the permeability of porous sublayers. Multicellular sublayer flow circulation strength is amplified by the conductivity of the solid interfaces. Higher modes are also examined for varying permeability ratio and thermal conductivity ratio. A different flow pattern is observed for mode 3 when the permeability ratio is either very much less than one or much greater than one. Onset of the convection is sensitive to the increasing number of inhomogeneous porous sublayers of the layered porous system.
Evidence of cluster dipole states in germanium detectors operating at temperatures below 10 K
Authors: Mei D.-M. , Panth R. , Kooi K. , Mei H. , Bhattarai S. , Raut M. , Acharya P. , Wang G.-J.
Published: June 2022

By studying charge trapping in germanium detectors operating at temperatures below 10 K, we demonstrate for the first time that the formation of cluster dipole states from residual impurities is responsible for charge trapping. Two planar detectors with different impurity levels and types are used in this study. When drifting the localized charge carriers created by α particles from the top surface across a detector at a lower bias voltage, significant charge trapping is observed when compared to operating at a higher bias voltage. The amount of charge trapping shows a strong dependence on the type of charge carriers. Electrons are trapped more than holes in a p-type detector, while holes are trapped more than electrons in an n-type detector. When both electrons and holes are drifted simultaneously using the widespread charge carriers created by γ rays inside the detector, the amount of charge trapping shows no dependence on the polarity of bias voltage.
Effect of bed shrinkage on iron ore sintering process
Authors: Xu Jiarui , Zhang Xiaohui , Qing Shan
Published: June 2022

There exist complex chemical reactions and phase transition processes—melting and solidification—in the iron ore sintering process. This will result in bed shrinkage and has an important impact on the sintering process and sinter properties. Numerical simulation was carried out in this paper, and it is based on the porous medium and double-energy equation model, coupled with the porosity shrinkage model. The influence of bed shrinkage on the sintering process was explored and revealed by comparing the calculation results, considering and neglecting bed shrinkage. The results indicate that bed shrinkage has less influence on the highest temperature in the area above 0.15 m of the sintered bed but it severely decreases by about 60 K below 0.15 m. Bed shrinkage makes the thickness of the combustion zone reduce by about 1.367, 1.398, and 4.367 cm at 500, 1000, and 1500 s, respectively. Bed shrinkage reduces the vertical sintering velocity, and the highest temperature of flue gas decreased by 77 K approximately; in addition, it also has a delay of 50 s to reach the highest temperature. The volume concentration of SO2 in the flue gas remains unchanged considering bed shrinkage, but it has a delay of about 50 s to reach the maximum value.
Fluidization dynamics in an impinging-jet-driven bioreactor for artificial liver system
Authors: Pan Menghan , Lu Juan , Wang Wentao , Chen Xiaodong , Liu Qingquan , Li Lanjuan
Published: June 2022

Liquid–solid fluidized beds have been applied in the field of bioreactors for artificial liver systems. This paper uses a coupling method of computational fluid dynamics and discrete element method to numerically study the fluidization dynamics of an impinging-jet-driven bioreactor. A long tube is placed at the centerline of a cylindrical container in the bioreactor. The liquid is discharged toward the bottom of the container to form an impinging jet to drive the fluidization process of the microcapsules. The bioreactor's bed expansion height, porosity distribution, and interaction between the liquid and microcapsules are analyzed at different microcapsule densities, sizes, and flow rates. It is found that the bed expansion is proportional to the inlet flow rate and inversely proportional to the microcapsule density and size. The distribution of porosity indicates overall even fluidization, except for a dead region near the bottom periphery of the bioreactor. The dead region shrinks with increasing flow rate and expands with increasing density and size of the microcapsules. It is found that the interaction of microcapsules may play an essential role in the variations of the dead region. Understanding the fluidization dynamics of the impinging-jet-driven bioreactor is crucial in bioreactor design and optimization to improve its performance.
Spatial–temporal evolution of the pressure field generated by a plasma actuator in quiescent air
Authors: Zhang Xin , Wang Yong
Published: June 2022

Dielectric barrier discharge plasma actuators, capable of generating quasi-steady wall jets, are well suited for flow control on various problems. Compared with the detail related to the induced velocity field, there are limited results available for the pressure field created by the plasma actuator. However, the profound merits of understanding the evolution of the pressure field are to reveal the controlling mechanism. Here, the time-averaged and the phase-averaged pressure field distributions are obtained by using a pressure reconstruction method based on the velocity field from particle image velocimetry experiments. According to the discharge regimes, the formation mechanism of the pressure field is discussed. During the streamer discharge stage, the pressure close to the upper electrode is decreased under the influence of the induced heating caused by the high-frequency and high-amplitude pulsed current, leading to the air above the plasma actuator being drawn toward the wall surface. During the glow discharge stage, under the effect of suction generated by the streamer discharge, the pressure near the wall is increased and the plasma actuator generates a favorable pressure gradient, which provides advantageous conditions for the airflow acceleration. During the discharge quenching stage, the effect of the plasma actuator vanishes and the influence of viscous force is strengthened. Therefore, the adverse pressure gradient is gradually formed and the velocity of the wall jet is decreased compared to that of the glow discharge stage. The change of pressure field in a period can be summarized into three processes: pressurization, pressure release, and pressure recovery.
Soil nitrous oxide emissions in a maize (
Authors: Alvarez Carolina , Álvarez Carina R. , Alves Bruno J. R. , Costantini Alejandro O.
Published: June 2022

Context An appropriate use of the fertiliser technology may lead to a more efficient N absorption and to the reduction of economic and environmental costs. Aims This study sought to quantify N2O emissions generated from soil and the residual nitrate (NO3−) up to 2 m depth in field conditions in a maize crop under supplementary irrigation and fertilised with two nitrogen (N) sources (UAN and urea) at increasing N rates (0, 80, 160 and 250 kg N ha−1) in the Semi-arid Argentine Pampas. Methods Throughout the crop cycle, emissions were monitored daily with static chambers during the first week after fertilisation; then sampling frequency was gradually reduced until the end of the experiment. Key results There were no yield responses to the use of different sources and N rates. Crop N uptake saturated at 80 kg N ha−1, reaching 300–310 kg N ha−1. Residual NO3− increased significantly with the highest rates of N fertiliser. Total N2O emissions differed significantly only among fertiliser rates. The N2O emissions were lower at 80 than at 160 and 250 kg N ha−1. Conclusions The N2O emissions measured were lower than those calculated by the IPCC, even when only direct emissions were considered. No grain yield increase was observed due to N fertilisation, with a non-limiting supply of N-NO3− at the beginning of the crop cycle and of N from mineralisation. Implications This excess of N can generate negative environmental effects due to higher emissions of N2O and residual N-NO3− that can be leached.
Temporal relations between peripheral and central arousals in good and poor sleepers
Authors: Ribeiro Ana , Gabriel Rachel , Garcia Bernardo , Cuccio Casey , Aqeel William , Moreno Alejandro , Landeen Colby , Hurley Arlene , Kavey Neil , Pfaff Donald
Published: June 2022

Good sleepers and patients with insomnia symptoms (poor sleepers) were tracked with two measures of arousal; conventional polysomnography (PSG) for electroencephalogram (EEG) assessed cortical arousals, and a peripheral arterial tonometry device was used for the detection of peripheral nervous system (PNS) arousals associated with vasoconstrictions. The relationship between central (cortical) and peripheral (autonomic) arousals was examined by evaluating their close temporal dynamics. Cortical arousals almost invariably were preceded and followed by peripheral activations, while large peripheral autonomic arousals were followed by cortical arousals only half of the time. The temporal contiguity of these two types of arousals was altered in poor sleepers, and poor sleepers displayed a higher number of cortical and peripheral arousals compared with good sleepers. Given the difference in the number of peripheral autonomic arousals between good and poor sleepers, an evaluation of such arousals could become a means of physiologically distinguishing poor sleepers.
Ion-mediated desorption of asphaltene molecules from carbonate and sandstone structures
Authors: Ahmadi Pouyan , Aghajanzadeh Mohammadreza , Asaadian Hamidreza , Khadivi Armin , Kord Shahin
Published: June 2022

As more and more oil recovery scenarios use seawater, the need to identify the possible mechanisms of wettability state changes in oil reservoirs has never been greater. By using molecular dynamics simulations, this study sheds light on the effect of ions common to seawater (Ca2+, K+, Mg2+, Na+, Cl−, HCO3−, SO4
2−) on the affinity between silica and carbonate as the traditional rock types and asphaltene molecules as an important contributing factor of reservoir oil wetness. In the case of carbonate and silica being the reservoir rock types, the measured parameters indicate good agreement with each other, meaning that (HCO3
− & SO4
2−) and (Na+ & Cl−) ions reached maximum bonding energies of (25485, 25511, 4096, and −4093 eV, respectively). As with the surface charge density measurements, the results of the non-bonding energies between the individual atomic structures agree with those from the simulation cell. In the presence of a silica surface, the radial distribution function (RDF) results determine that the peak of the maximum value for the distribution of the ions is 4.2. However, these values range from 3 to 6.6, suggesting that different ions perform better under the influence of carbonate rock. As these ions are distributed in the simulation box along with the adsorption domain, the conditions for sequestering asphaltene from the rock surface are made ideal for dissolution and removal. At equal ion strength, measuring the distance between the center of mass of rocks and asphaltene structures reveals a maximum repulsion force of 22.1 Å and a maximum detachment force of 10.4 Å in the presence of SO4
2− and Na+ ions on carbonate and silica surfaces.
Coherent energy fluctuation theorems: theory and experiment
Authors: Khan K , Araújo J Sales , Magalhães W F , Aguilar G H , Bernardo B de Lima
Published: June 2022

Fluctuation theorems (FT) reveal crucial properties about the nature of non-equilibrium dynamics by constraining the statistical distribution of quantities such as heat, work and entropy production. Here, we report theoretical and experimental results regarding two FT for a new quantity, named coherent energy, which is an energy form directly associated with the coherences of a quantum state. The FT are verified using the two-point measurement protocol with an all-optical setup in which the system information is encoded in the polarization of one photon of a pair. From the outcomes of our experiment we directly assess the energy probability distributions. We also demonstrate an universal bound on the energy of thermal states under the action of unitary operations, which could be the first step to establish an arrow of time for reversible processes.