bluuebunny/crossref_metadata_2025 huggingface dataset:
Specific initial training standards are needed to dive for science in Europe, Occupational vs. Citizen Science Diving
Authors: Féral Jean-Pierre , Norro Alain
Published: October 2023

Today, collaboration between scientific research and civil society is growing significantly. The general public’s curiosity drives it to engage with the scientific process and culture and in the search for solutions to complex issues (economic, social, health, environmental, cultural, educational, or ethical). Clarification is needed to differentiate between occupational scientific activity and citizen-based science. They do not require the same scientific and technical skills despite using similar equipment and their legal and administrative frameworks being totally different. The confusion created by the indiscriminate use of the same term “scientific diving” to refer to different training courses and activities compromises the quality of existing occupational standards and, ultimately, has a negative impact on the safety of the activity at work. A clear definition of Citizen Scientific Diving and Occupational Scientific Diving makes it possible to differentiate between the objectives and target groups of these two activities and their legal framework. There is a need to establish an accepted and shared standard in the occupational field and to ensure the mobility of scientists. A long process undertaken by a motivated scientific community (late 1980s-2000s) led to the establishment of European initial training standards for Occupational Scientific Diving through the ESDP-European Scientific Diving Panel (firstly under the aegis of the European Marine Board, now of the MARS-European marine stations network). The quality and general acceptance of these standards by a large part of the European scientific community have already adopted them in the occupational health and safety legislation of seven European countries (Belgium, Finland, France, Germany, Norway, Sweden, and the UK in 2023). Adopting them in other countries’ health and safety legislation is still desirable. This will increase their recognition, acceptance and use for the benefit of scientific work. Building bridges between academic science and non-academic citizen science is possible and this is done by developing coherent projects that produce results that benefit both science and society. While distinguishing between the two, as an added value, this approach could better guide the recreational diving training sector in developing a new market.
The causality between gut microbiome and liver cirrhosis: a bi-directional two-sample Mendelian randomization analysis
Authors: Xiao Qing-Ao , Yang Yun-Fei , Chen Lin , Xie Ying-Chun , Li Hai-Tao , Fu Zhi-Gang , Han Qiang , Qin Jia , Tian Jie , Zhao Wen-Jiang , Cai Fei , Hu Yin-Tao , Ai Lin-Feng , Li Chao , Chen Xu-Ying , Wang Decheng , Tan Yu-Yan , Xia Xuan , Zhang Xiao-Lin
Published: October 2023

Background and aim

Previous studies have reported an association between gut microbiota and cirrhosis. However, the causality between intestinal flora and liver cirrhosis still remains unclear. In this study, bi-directional Mendelian randomization (MR) analysis was used to ascertain the potential causal effect between gut microbes and cirrhosis.

Methods

Large-scale Genome Wide Association Study (GWAS) data of cirrhosis and gut microbes were obtained from FinnGen, Mibiogen consortium, and a GWAS meta-analysis of Alcoholic cirrhosis (ALC). Two-sample MR was performed to determine the causal relationship between gut microbiota and cirrhosis. Furthermore, a bi-directional MR analysis was employed to examine the direction of the causal relations.

Result

In MR analysis, we found that 21 gut microbiotas were potentially associated with cirrhosis. In reverse MR analysis, 11 gut microbiotas displayed potentially associations between genetic liability in the gut microbiome and cirrhosis. We found that the family Lachnospiraceae (OR: 1.59, 95% CI:1.10–2.29) might be harmful in cirrhotic conditions (ICD-10: K74). Furthermore, the genus Erysipelatoclostridium might be a protective factor for cirrhosis (OR:0.55, 95% CI:0.34–0.88) and PBC (OR:0.68, 95% CI:0.52–0.89). Combining the results from the MR analysis and reverse MR analysis, we firstly identified the Genus Butyricicoccus had a bi-directional causal effect on PBC (Forward: OR: 0.37, 95% CI:0.15–0.93; Reverse: OR: 1.03, 95% CI:1.00–1.05).

Conclusion

We found a new potential causal effect between cirrhosis and intestinal flora and provided new insights into the role of gut microbiota in the pathological progression of liver cirrhosis.
Differential encoding of temporally evolving color patterns across nearby V1 neurons
Authors: Kristensen Sofie Skårup , Jörntell Henrik
Published: October 2023

Whereas studies of the V1 cortex have focused mainly on neural line orientation preference, color inputs are also known to have a strong presence among these neurons. Individual neurons typically respond to multiple colors and nearby neurons have different combinations of preferred color inputs. However, the computations performed by V1 neurons on such color inputs have not been extensively studied. Here we aimed to address this issue by studying how different V1 neurons encode different combinations of inputs composed of four basic colors. We quantified the decoding accuracy of individual neurons from multi-electrode array recordings, comparing multiple individual neurons located within 2 mm along the vertical axis of the V1 cortex of the anesthetized rat. We found essentially all V1 neurons to be good at decoding spatiotemporal patterns of color inputs and they did so by encoding them in different ways. Quantitative analysis showed that even adjacent neurons encoded the specific input patterns differently, suggesting a local cortical circuitry organization which tends to diversify rather than unify the neuronal responses to each given input. Using different pairs of monocolor inputs, we also found that V1 neocortical neurons had a diversified and rich color opponency across the four colors, which was somewhat surprising given the fact that rodent retina express only two different types of opsins. We propose that the processing of color inputs in V1 cortex is extensively composed of multiple independent circuitry components that reflect abstract functionalities resident in the internal cortical processing rather than the raw sensory information per se.
Integrate prediction of machine learning for single ACoA rupture risk: a multicenter retrospective analysis
Authors: Li Yang , Huan Linchun , Lu Wenpeng , Li Jian , Wang Hongping , Wang Bangyue , Song Yunfei , Peng Chao , Wang Jiyue , Yang Xinyu , Hao Jiheng
Published: October 2023

Background

Statistically, Anterior communicating aneurysm (ACoA) accounts for 30 to 35% of intracranial aneurysms. ACoA, once ruptured, will have an acute onset and cause severe neurological dysfunction and even death. Therefore, clinical analysis of risk factors related to ACoA and the establishment of prediction model are the benefits to the primary prevention of ACoA.

Methods

Among 1,436 cases of single ACoA patients, we screened 1,325 valid cases, classified risk factors of 1,124 cases in the ruptured group and 201 cases in the unruptured group, and assessed the risk factors, respectively, and predicted the risk of single ACoA rupture by using the logistic regression and the machine learning.

Results

In the ruptured group (84.8%) of 1,124 cases and the unruptured group (15.2%) of 201 cases, the multivariable logistic regression (MLR) model shows hemorrhagic stroke history (OR 95%CI, p:0.233 (0.120–0.454),<0.001) and the age stratification of 60–69 years (OR 95%CI, p:0.425 (0.271–0.668),<0.001) has a significant statistic difference. In the RandomForest (RF) model, hemorrhagic stroke history and age are the best predictive factors.

Conclusion

We combined the analysis of MLR, RF, and PCA models to conclude that hemorrhagic stroke history and gender affect single ACoA rupture. The RF model with web dynamic nomogram, allows for real-time personalized analysis based on different patients’ conditions, which is a tremendous advantage for the primary prevention of single ACoA rupture.

Clinical trial registration

https://www.chictr.org.cn/showproj.html?proj=178501.
Deep learning-driven MRI trigeminal nerve segmentation with SEVB-net
Authors: Zhang Chuan , Li Man , Luo Zheng , Xiao Ruhui , Li Bing , Shi Jing , Zeng Chen , Sun BaiJinTao , Xu Xiaoxue , Yang Hanfeng
Published: October 2023

Purpose

Trigeminal neuralgia (TN) poses significant challenges in its diagnosis and treatment due to its extreme pain. Magnetic resonance imaging (MRI) plays a crucial role in diagnosing TN and understanding its pathogenesis. Manual delineation of the trigeminal nerve in volumetric images is time-consuming and subjective. This study introduces a Squeeze and Excitation with BottleNeck V-Net (SEVB-Net), a novel approach for the automatic segmentation of the trigeminal nerve in three-dimensional T2 MRI volumes.

Methods

We enrolled 88 patients with trigeminal neuralgia and 99 healthy volunteers, dividing them into training and testing groups. The SEVB-Net was designed for end-to-end training, taking three-dimensional T2 images as input and producing a segmentation volume of the same size. We assessed the performance of the basic V-Net, nnUNet, and SEVB-Net models by calculating the Dice similarity coefficient (DSC), sensitivity, precision, and network complexity. Additionally, we used the Mann–Whitney U test to compare the time required for manual segmentation and automatic segmentation with manual modification.

Results

In the testing group, the experimental results demonstrated that the proposed method achieved state-of-the-art performance. SEVB-Net combined with the ωDoubleLoss loss function achieved a DSC ranging from 0.6070 to 0.7923. SEVB-Net combined with the ωDoubleLoss method and nnUNet combined with the DoubleLoss method, achieved DSC, sensitivity, and precision values exceeding 0.7. However, SEVB-Net significantly reduced the number of parameters (2.20 M), memory consumption (11.41 MB), and model size (17.02 MB), resulting in improved computation and forward time compared with nnUNet. The difference in average time between manual segmentation and automatic segmentation with manual modification for both radiologists was statistically significant (p < 0.001).

Conclusion

The experimental results demonstrate that the proposed method can automatically segment the root and three main branches of the trigeminal nerve in three-dimensional T2 images. SEVB-Net, compared with the basic V-Net model, showed improved segmentation performance and achieved a level similar to nnUNet. The segmentation volumes of both SEVB-Net and nnUNet aligned with expert annotations but SEVB-Net displayed a more lightweight feature.
Whole exome sequencing identifies common mutational landscape of cervix and endometrium small cell neuroendocrine carcinoma
Authors: Wang Wei , Zhang Fan , Li Yan , Chen Bo , Gu Yu , Shan Ying , Li Yaping , Chen Wei , Jin Ying , Pan Lingya
Published: October 2023

Background

Primary small cell neuroendocrine carcinomas of the cervix and endometrium are rare gynecological malignancies with limited treatment options. This study aimed to improve the understanding of the carcinogenesis process and identify potential therapeutic targets for these two tumor types by constructing the mutational landscape at the whole exome level.

Methods

Primary tumor tissues and their matched blood samples were obtained from 10 patients with small cell cervical neuroendocrine carcinoma (NECC) and five patients with small cell endometrial neuroendocrine carcinoma (NECE). Whole exome sequencing was performed to construct the somatic mutation profiles. Mutational signature and recurrent mutated gene analysis were used to identify tumor subtypes and common carcinogenesis processes.

Results

Based on the burden of different mutational signatures, the NECCs in this work can be divided into two subtypes, including the mismatch repair deficiency like (dMMR-like) type (4/10) and the high spontaneous deamination type (6/10). Components of the PI3K/AKT signaling and RAS signaling were exclusively mutated in these two subtypes, respectively. The integration of human papillomavirus made a limited contribution to tumorigenesis in NECC (20%). The dysfunction of the mismatch repair system and microsatellite instability are the major features of NECE. PI3K/AKT, JAK/STAT signaling, and chromatin remodeling activity were the common mutated pathways in NECE. PIK3CA, WNK2, and KMT2B underwent mutations in both the dMMR-like subtype of NECC (50% – 75%) and in NECE (60% – 80%) specimens, while exhibiting infrequent mutational occurrences in publicly available data pertaining to neuroendocrine carcinomas of the lung or bladder (< 10%).

Conclusion

We identified the two subtypes of NECC with distinct mutated pathways and potential therapy targets. The dMMR-like type NECC and NECE may share a similar carcinogenesis process that include dysfunction of PI3K/AKT signaling, cell cycle, antiapoptotic processes, and chromatin remodeling activity.
Successful therapy using high-dose furmonertinib for non-small cell lung cancer with leptomeningeal metastasis: a case report and literature review
Authors: Chen Ting , Chen Jie , Liu De-sheng , Shu Yan-ling , Fu Mao-yue , Gou Hai-jun , Lei Kai-jian , Jia Yu-ming
Published: October 2023

Background

Lung cancer is the second most common form of malignant tumor and has the highest mortality rate worldwide. Among its subtypes, lung adenocarcinoma is the most prevalent. Leptomeningeal metastasis (LM) is rare and is characterized by a dismal prognosis, with overall survival periods typically spanning 4 to 6 weeks without treatment. However, in specific cases, survival can be extended to 4 to 6 months with appropriate therapy. The recent approval of third-generation tyrosine kinase inhibitors (TKIs), such as osimertinib, aumolertinib, and furmonertinib, has introduced promising treatment options for individuals with non-small cell lung cancer (NSCLC) who develop LM after developing resistance to first- and second-generation TKIs. These third-generation TKIs exhibit an enhanced ability to penetrate the blood–brain barrier (BBB), opening up new avenues for managing this challenging condition.

Case summary

We report the case of a 48-year-old Chinese man diagnosed with advanced NSCLC harboring an epidermal growth factor receptor (EGFR) mutation. Following a pulmonary lobectomy and postoperative adjuvant therapy with gefitinib, the patient was diagnosed with LM, which was confirmed by his neurologic symptoms, cerebrospinal fluid cytologic analysis, and cranial enhancement magnetic resonance imaging. Subsequently, he received oral treatment in the form of 160 mg of furmonertinib daily. After 5 days of furmonertinib therapy, the patient recovered from lethargy, with an obvious improvement in cognitive function. Follow-up visits revealed a 6-month survival period following the LM diagnosis. Patients with NSCLC and LM typically present with severe symptoms, and the efficacy of systemic treatment, intrathecal chemotherapy, and radiotherapy remains unsatisfactory. We hope that this specific case provide valuable insights into the management of patients with EGFR mutation-associated NSCLC with LM.

Conclusion

Furmonertinib, a third-generation EGFR TKI with notable BBB penetration, shows promise in LM control and the rapid alleviation of intracranial symptoms. Further investigations into appropriate dosage and toxicity management are imperative.
Anlotinib combined with pembrolizumab as first-line treatment for advanced pulmonary sarcomatoid carcinoma: a case report and literature review
Authors: Wen Yingmei , Dong Yi , Yi Lina , Yang Guifang , Xiao Mengxia , Li Qingqing , Zhao Chen , Ye Dafu , Yao Yi
Published: October 2023

Pulmonary sarcomatoid carcinoma (PSC) is an uncommon variant of non-small cell lung cancer (NSCLC), known for its unfavorable prognosis. Previous studies have elucidated that PSC generally exhibits a significant expression of programmed death-ligand 1 (PD-L1), an elevated tumor mutation burden, and marked vascular invasion. These factors imply the possible effectiveness of treatments like immunotherapy and anti-angiogenic therapy. The subject of this case was a 65-year-old male diagnosed with advanced PSC, characterized by high PD-L1 expression and devoid of known driver gene mutations. Owing to the restrictions imposed by the COVID-19 pandemic, the patient initially underwent home-based treatment with anlotinib, which led to symptomatic improvement after a single treatment cycle. Subsequent hospitalization allowed for the administration of anlotinib plus Pembrolizumab, resulting in a partial response. Radiotherapy was necessitated due to local disease progression. But after 15 cycles of treatment with Pembrolizumab, hyperprogression was observed. The patient’s overall survival spanned 14 months, with no evident adverse reactions to the medications. Genomic analysis revealed potential associations between treatment efficacy and mutations in the TP53, NF1, and MET genes. This case underscores the effectiveness and safety of a first-line treatment regimen combining pan-target anti-angiogenic therapy (anlotinib) with anti-tumor immunotherapy.
Metastasis of ovarian cancer to nasal skin and skin on the trunk: a rare case report
Authors: Chen Chen , Yingyao Ouyang , Yan Xiang , Qianru He , Hong Wang , Chen Chen , Lei Yang
Published: October 2023

Cutaneous metastases of ovarian cancer are rare and often have poor prognosis. We report a case of a 62-year-old woman with recurrent low-grade serous ovarian cancer, who presented with lung, brain, and multiple skin (nasal and anterior chest wall) metastases approximately six months after the initial diagnosis. In this case, Nijmegen breakage syndrome carrier status caused by RAD50 heterozygous mutation and previous bevacizumab therapy could be the predisposing factor for cutaneous metastases. The patient was treated with local radiotherapy (nasal skin and brain, 30Gy/6f/1.2W) and three courses of chemotherapy with albumin-bound paclitaxel and carboplatin, resulting in drastic remission of the cutaneous metastases. Unfortunately, treatment interruption resulted in rapid tumor progression, followed by death. This case represents an interesting example of cutaneous metastasis of ovarian cancer with rare clinical manifestations, unique genetic mutations, and reasonable response to treatment. Chemoradiotherapy might be an appropriate option for cutaneous metastases of ovarian cancer. Nevertheless, we still hope to find out the best treatment strategy after collecting and reviewing more cases in the future.
A prediction model for neonatal necrotizing enterocolitis in preterm and very low birth weight infants
Authors: Feng Baoying , Zhang Zhihui , Wei Qiufen , Mo Yan , Luo Mengmeng , Jing Lianfang , Li Yan
Published: October 2023

Objectives

Neonatal necrotizing enterocolitis (NEC) is a severe gastrointestinal disease that primarily affects preterm and very low birth weight infants, with high morbidity and mortality. We aim to build a reliable prediction model to predict the risk of NEC in preterm and very low birth weight infants.

Methods

We conducted a retrospective analysis of medical data from infants (gestational age <32 weeks, birth weight <1,500 g) admitted to Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region. We collected clinical data, randomly dividing it into an 8:2 ratio for training and testing. Multivariate logistic regression was employed to identify significant predictors for NEC. Principal component analysis was used for dimensionality reduction of numerical variables. The prediction model was constructed through logistic regression, incorporating all relevant variables. Subsequently, we calculated performance evaluation metrics, including Receiver Operating Characteristic (ROC) curves and confusion matrices. Additionally, we conducted model performance comparisons with common machine learning models to establish its superiority.

Results

A total of 292 infants were included, with 20% (n = 58) randomly selected for external validation. Multivariate logistic regression revealed the significance of four predictors for NEC in preterm and very low birth weight infants: temperature (P = 0.003), Apgar score at 5 min (P = 0.004), formula feeding (P = 0.007), and gestational diabetes mellitus (GDM, P = 0.033). The model achieved an accuracy of 82.46% in the test set with an F1 score of 0.90, outperforming other machine learning models (support vector machine, random forest).

Conclusions

Our logistic regression model effectively predicts NEC risk in preterm and very low birth weight infants, as confirmed by external validation. Key predictors include temperature, Apgar score at 5 min, formula feeding, and GDM. This study provides a vital tool for NEC risk assessment in this population, potentially improving early interventions and child survival. However, clinical validation and further research are necessary for practical application.
Compounds targeting ferroptosis in breast cancer: progress and their therapeutic potential
Authors: Xu Chuchu , Chen Yian , Yu Qinghong , Song Jiaqing , Jin Ying , Gao Xiufei
Published: October 2023

In recent years, there has been a significant increase in the incidence of Breast cancer (BC), making it the most common cancer among women and a major threat to women’s health. Consequently, there is an urgent need to discover new and effective strategies for treating BC. Ferroptosis, a novel form of cell death characterized by the accumulation of iron-dependent lipid reactive oxygen species, has emerged as a distinct regulatory pathway separate from necrosis, apoptosis, and autophagy. It is widely recognized as a crucial factor in the development and progression of cancer, offering a promising avenue for BC treatment. While significant progress has been made in understanding the mechanisms of ferroptosis in BC, drug development is still in its early stages. Numerous compounds, including phytochemicals derived from dietary sources and medicinal plants, as well as synthetic drugs (both clinically approved medications and laboratory reagents), have shown the ability to induce ferroptosis in BC cells, effectively inhibiting tumor growth. This comprehensive review aims to examine in detail the compounds that target ferroptosis in BC and elucidate their potential mechanisms of action. Additionally, the challenges associated with the clinical application of ferroptosis-inducing drugs are discussed, offering valuable insights for the development of novel treatment strategies for BC.
Integration of metabolomics and network pharmacology to reveal the protective mechanism underlying Qibai Pingfei capsule on chronic obstructive pulmonary disease
Authors: Xie Jinghui , Liu Mengxiang , Gao Yating , Liu Changan , Wu Fan , Tong Jiabing , Li Zegeng , Zhu Jie
Published: October 2023

In this study, we have employed metabolomics technology in combination with network pharmacology to ascertain the key metabolites and hub genes. The objective was to explore the pathway of Qibai Pingfei Capsule (QBPF) in treating COPD through metabolomics. We identified 96 differential metabolites in the lung tissues of rats belonging to control and model groups, out of which 47 were observed to be critical (VIP >2, p < 0.05). Furthermore, 16 important differential metabolites were reversed after QBPF treatment. Using network pharmacology, we identified 176 core targets of 81 drug-active ingredients. Our comprehensive analysis of network pharmacology and metabolomics enabled us to identify a core target, prostaglandin-endoperoxide synthase 2 (PTGS2), and a core metabolic pathway for glutathione metabolism. Finally, the result of molecular docking showed that PTGS2 had strong binding activity to 18 compounds including Fumarine and Kaempferol, etc.. PTGS2 is a marker of ferroptosis, so we wanted to explore whether QBPF could inhibit ferroptosis in COPD. The results showed that ferroptosis was involved in the pathogenesis of COPD, and QBPF could inhibit the occurrence of ferroptosis. In conclusion, the mechanism of QBPF for treating COPD may be related to PTGS2 expression, glutathione metabolism and ferroptosis.
Changes in neuromuscular activation, heart rate and rate of perceived exertion over the course of a wheelchair propulsion fatigue protocol
Authors: Minder Ursina , Arnet Ursina , Müller Erich , Boninger Michael , Bossuyt Fransiska M.
Published: October 2023

Shoulder pain is common in persons with spinal cord injury and has been associated with wheelchair use. Fatigue related compensation strategies have been identified as possibly impacting the development of shoulder injury and pain. The purpose of this study was to investigate the progression of performance fatigability (i.e., decline in objective measure of performance including neuromuscular activation and increase in heart rate) and perceived fatigability (i.e., increased perceived exertion) during a 15-min fatigue protocol including maximum voluntary overground wheelchair propulsion. Fifty participants with paraplegic spinal cord injury completed three 4-min rounds of wheelchair propulsion, separated by 90 s of rest, on a figure-8 course consisting of two turns and full stops per lap in their manual wheelchairs (ClinicalTrials.gov: NCT03153033). Electromyography (EMG) signal of five muscles acting on the shoulder joint, heart rate (HR), and rate of perceived exertion (RPE) were measured at the beginning and end of every 4 min of propulsion. Root Mean Square (RMS) and Mean Power Frequency were calculated from EMG data. There was a significant increase in %RMS of the pectoralis major pars sternalis and trapezius pars descendens, HR, and RPE with greatest changes during the first 4 min of the protocol. The observed changes in neuromuscular activation in only two of the shoulder muscles may impact muscular imbalances and the development of shoulder injuries and should be further studied. The current study gives clearer insight into the mechanisms of performance fatigability and perceived fatigability throughout a wheelchair propulsion fatigue protocol.
Genetic analysis of basal stalk rot resistance introgressed from wild Helianthus petiolaris into cultivated sunflower (Helianthus annuus L.) using an advanced backcross population
Authors: Talukder Zahirul I. , Underwood William , Misar Christopher G. , Li Xuehui , Seiler Gerald J. , Cai Xiwen , Qi Lili
Published: October 2023

Introduction

Sclerotinia sclerotiorum is a serious pathogen causing severe basal stalk rot (BSR) disease on cultivated sunflower (Helianthus annuus L.) that leads to significant yield losses due to insufficient resistance. The wild annual sunflower species H. petiolaris, commonly known as prairie sunflower is known for its resistance against this pathogen. Sunflower resistance to BSR is quantitative and determined by many genes with small effects on the resistance phenotype. The objective of this study was to identify loci governing BSR resistance derived from H. petiolaris using a quantitative trait loci (QTL) mapping approach.

Methods

BSR resistance among lines of an advanced backcross population (AB-QTL) with 174 lines developed from a cross of inbred line HA 89 with H. petiolaris PI 435843 was determined in the field during 2017-2019, and in the greenhouse in 2019. AB-QTL lines and the HA 89 parent were genotyped using genotyping-by-sequencing and a genetic linkage map was developed spanning 997.51 cM and using 1,150 SNP markers mapped on 17 sunflower chromosomes.

Results and discussion

Highly significant differences (p<0.001) for BSR response among AB-QTL lines were observed disease incidence (DI) in all field seasons, as well as disease rating (DR) and area under the disease progress curve (AUDPC) in the greenhouse with a moderately high broad-sense heritability (H2) of 0.61 for the tested resistance parameters. A total of 14 QTL associated with BSR resistance were identified on nine chromosomes, each explaining a proportion of the phenotypic variation ranging from 3.5% to 28.1%. Of the 14 QTL, eight were detected for BSR resistance in the field and six were detected under greenhouse conditions. Alleles conferring increased BSR resistance were contributed by the H. petiolaris parent at 11 of the 14 QTL.
iBehavior—a preliminary proof of concept study of a smartphone-based tool for the assessment of behavior change in neurodevelopmental disabilities
Authors: Dakopolos Andrew , Glassman Dana , Scott Haleigh , Bass Michael , Hessl David
Published: October 2023

Purpose

The purpose of the present study was to describe the content and function of iBehavior, a smartphone-based caregiver-report electronic ecological momentary assessment (eEMA) tool developed to assess and track behavior change in people with intellectual and developmental disabilities (IDDs), and to examine its preliminary validity.

Methods

Ten parents of children (ages of 5–17 years) with IDDs (n = 7 with fragile X syndrome; n = 3 with Down syndrome) rated their child’s behavior (aggression and irritability, avoidant and fearful behavior, restricted and repetitive behavior and interests, and social initiation) using iBehavior once daily for 14 days. At the conclusion of the 14-day observation period, parents completed traditional rating scales as validation measures, as well as a user feedback survey.

Results

Across the 140 possible observations, 8 were skipped, leading to a 94% response rate over 10 participants’ observation periods. Participants also completed 100% of items for each of their logged observations. Parent ratings using iBehavior showed emerging evidence of convergent validity among domains with traditional rating scales including the Behavior Rating Inventory of Executive Function 2 (BRIEF-2), and Aberrant Behavior Checklist-Community (ABC-C). iBehavior was feasible in the sample, and parent feedback indicated high overall satisfaction.

Conclusion

Results of the present pilot study indicate successful implementation and preliminary feasibility and validity of an eEMA tool for use as a behavioral outcome measure in IDDs.
Prevalence and associated clinical factors for overweight and obesity in young first-episode and drug-naïve Chinese patients with major depressive disorder
Authors: Zhang Jian-Jun , Wang Xiao-Qian , Zeng Qun , Gao Na , Zhang Xiang-Yang
Published: October 2023

Background

Obesity and overweight are common in young patients with major depressive disorder (MDD). However, the prevalence and associated clinical factors of obesity/overweight in young first-episode and drug-naïve (FEDN) MDD patients are rarely reported in China.

Methods

A cross-sectional study of 917 young patients (aged 18–35 years) with FEDN MDD was performed. Demographic and clinical data were collected. Depression, anxiety, and psychotic symptoms were assessed using the Hamilton Depression Scale (HAMD), the Hamilton Anxiety Scale (HAMA), and the Positive and Negative Syndrome Scale (PANSS) positive subscale, respectively.

Results

Among the young MDD patients, the prevalence of obesity and overweight was 4.14 and 52.89%, respectively. Compared to normal-weight patients, overweight patients were older, had a greater age of onset, and had higher TSH and TG levels. Male MDD patients had a higher risk of obesity than female patients. Compared to obese patients, normal-weight and overweight patients had significantly lower HAMD scores, TC levels, and rates of TSH abnormalities. Logistic regression analysis showed that age, age of onset, and sex were independently associated with obesity, and TSH was independently associated with both obesity and overweight, in young MDD patients.

Conclusion

Our findings suggest a high prevalence of overweight and obesity in young FEDN MDD patients. Several demographic and clinical variables are independently associated with overweight/obesity in these young MDD patients.
Basis of preventive and non-pharmacological interventions in asthma
Authors: Clemente-Suárez Vicente Javier , Mielgo-Ayuso Juan , Ramos-Campo Domingo Jesús , Beltran-Velasco Ana Isabel , Martínez-Guardado Ismael , Navarro Jimenez Eduardo , Redondo-Flórez Laura , Yáñez-Sepúlveda Rodrigo , Tornero-Aguilera Jose Francisco
Published: October 2023

Asthma is one of the most common atopic disorders in all stages of life. Its etiology is likely due to a complex interaction between genetic, environmental, and lifestyle factors. Due to this, different non-pharmacological interventions can be implemented to reduce or alleviate the symptoms caused by this disease. Thus, the present narrative review aimed to analyze the preventive and non-pharmacological interventions such as physical exercise, physiotherapy, nutritional, ergonutritional, and psychological strategies in asthma treatment. To reach these aims, an extensive narrative review was conducted. The databases used were MedLine (PubMed), Cochrane (Wiley), Embase, PsychINFO, and CinAhl. Asthma is an immune-mediated inflammatory condition characterized by increased responsiveness to bronchoconstrictor stimuli. Different factors have been shown to play an important role in the pathogenesis of asthma, however, the treatments used to reduce its incidence are more controversial. Physical activity is focused on the benefits that aerobic training can provide, while physiotherapy interventions recommend breathing exercises to improve the quality of life of patients. Nutritional interventions are targeted on implement diets that prioritize the consumption of fruits and vegetables and supplementation with antioxidants. Psychological interventions have been proposed as an essential non-pharmacological tool to reduce the emotional problems associated with asthma.
Access to health care for migrants in French Guiana in 2022: a qualitative study of health care system actors
Authors: Brun-Rambaud Gabriel , Alcouffe Leslie , Tareau Marc-Alexandre , Adenis Antoine , Vignier Nicolas
Published: October 2023

Background

Access to health care is a major public health issue. The social determinants of health have a role in accessing health care and in meeting the health needs of populations. With 281 million international migrants around the world, population movements are another major issue. Migrants are particularly exposed to precariousness during their migratory journey and after their settlement. These vulnerabilities may have deleterious effects on their health status and on their social conditions. In French Guiana, 36% of the population is of foreign origin. The objective of this study is to explore the barriers and the facilitators to accessing health care for migrants in French Guiana in 2022, from the perspective of health care professionals, social workers and local NGO actors.

Methods

This research is an exploratory qualitative study based on the experiential knowledge of health care professionals, social workers and local NGO actors in French Guiana. 25 semi-structured interviews were conducted with these professionals and actors between April and June 2022, using an interview guide to explore their practices, representations and beliefs of access to health care and accompaniment of migrants in their patient journey. The interviews were transcribed and analyzed using the thematic analysis method.

Results

A total of 25 health care professionals, social workers and local NGO actors were included in the study. Participants highlighted that migrants are exposed to many factors hindering their access to health care in French Guiana (administrative complexity, language barriers, financial barriers, mobility issues, etc.). With the situations of great precariousness and the inadequacies of the public authorities, associative support (social, health and legal accompaniment process provided by NGOs and associations) has an important role in providing close support to migrants. Moreover, health mediation supports migrants in their social and health care journey to lead them toward empowerment. Health mediators contribute to promote a better understanding between professionals and migrants.

Conclusion

In French Guiana, associative support and health mediation promote access to health care and social accompaniment for migrants. This article highlights the issues surrounding access to health care, associative support and health mediation in the Guianese context, which is marked by significant socio-cultural diversity and precariousness. Considering the benefits of associative support and health mediation, as well as social inequalities in health, is essential for health care professionals, social workers, local NGO actors, associations, public health authorities and political decision-makers to initiate concrete and suitable actions in favor of access to health care and social support for migrants in French Guiana.
Pain after emergency treatments of symptomatic irreversible pulpitis and symptomatic apical periodontitis in the permanent dentition: a systematic review of randomized clinical trials
Authors: Alhilou Abdelrahman M. , Al-Moraissi Essam Ahmed , Bakhsh Abdulaziz , Christidis Nikolaos , Näsman Peggy
Published: October 2023

Background

Symptomatic irreversible pulpitis (SIP) or symptomatic apical periodontitis (SAP) are two painful conditions often warranting emergency treatment. The most common emergency treatments supported by evidence are pulpotomy and pulpectomy and are normally performed under time-constrained circumstances. However, there is no strong evidence of which treatment suggested in literature a clinician can use to reduce endodontic pain effectively. Therefore, the aim of this systematic review is to investigate the present knowledge on postoperative pain related to the two types of emergency treatments available for treating SIP and SAP.

Methods

Randomized controlled trials investigating postoperative pain after emergency treatments (pulpotomy and/or pulpectomy) on permanent dentition with signs and symptoms of SIP and/or SAP were searched in three major databases from 1978 until 2022. Risk of bias was assessed with Cochrane's tool.

Results

Only five studies fulfilled the inclusion criteria. The included studies indicated that pulpotomy and pulpectomy are both suitable treatment options for SAP and SIP, as they provide sufficient alleviation of pain in permanent dentition. However, inconsistent results were found between the included trials on which emergency treatment is more effective in reducing pain. Cochrane's tool revealed that the studies had a low risk of bias. Limitations found in the design of the included randomized control trials decreased the level of evidence. None of the included studies accounted for essential confounding variables, such as factors affecting pain (including the psychological aspects). Moreover, possible non-odontogenic pain was not assessed, and therefore, it was not excluded; hence, affecting the internal validity of the studies.

Conclusion

There are controversies within the available randomized control trials on which treatment is most effective in reducing emergency pain. This could be due to some weaknesses in the design of the clinical trials. Thus, further well-designed studies are warranted to draw conclusions on which emergency treatment is more effective in reducing pain.

Systematic Review Registration

PROSPERO (CRD42023422282).
Fault Detection for Point Machines: A Review, Challenges, and Perspectives
Authors: Hu Xiaoxi , Tang Tao , Tan Lei , Zhang Heng
Published: October 2023

Point machines are the actuators for railway switching and crossing systems that guide trains from one track to another. Hence, the safe and reliable behavior of point machines are pivotal for rail transportation. Recently, scholars and researchers have attempted to deploy various kinds of sensors on point machines for anomaly detection and/or incipient fault detection using date-driven algorithms. However, challenges arise when deploying condition monitoring and fault detection to trackside point machines in practical applications. This article begins by reviewing studies on fault and anomaly detection in point machines, encompassing employed methods and evaluation metrics. It subsequently conducts an in-depth analysis of point machines and outlines the envisioned intelligent fault detection system. Finally, it presents eight challenges and promising research directions along with a blueprint for intelligent point machine fault detection.
The Effect of Nanosilver-Based Preparation Added to Litter on Silver and Antagonistic Elements Content in Broiler Tissues and Organs
Authors: Czyż Katarzyna , Dobrzański Zbigniew , Wyrostek Anna , Senze Magdalena , Kowalska-Góralska Monika , Janczak Marzena
Published: October 2023

Nanosilver has a wide range of applications in many industries, including animal production. Its beneficial effects resulting from, among others, antibacterial properties are known; however, some concerns remain related to safety of its use and possible accumulation in the environment and all its components. This study aimed to analyze the content of silver and antagonistic elements (copper, selenium, zinc) in breast and thigh muscles, abdomen skin, liver, lung and blood serum of broilers exposed to a nanosilver-based preparation added to litter. Ross 308 broilers were divided into three groups: control and two experimental (84 birds in each) differing by the amount of preparation addition. The study lasted 24 days, after which the birds were slaughtered and the mentioned samples were collected for laboratory analyses using atomic absorption spectroscopy. An application of preparation based on nanosilver caused an increase in Ag content in chickens’ liver, lung and abdomen skin. Cu content decreased in all experimental groups, except for abdomen skin, while Zn content increased in most cases compared to the control. No clear decrease of the increasing tendency was found for Se. It did not demonstrate an antagonism with respect to the content of Cu, Se and Zn in examined samples.
Effect of Using Ensilaged Corn Wet Distillers’ Grains Plus Solubles (WDGS) as a Partial Replacement for Concentrated Feed for Wet Lot Fed Fatteners during Fattening on Growth Performance, Carcass Characteristics and Pork Quality
Authors: Roguski Mateusz , Łozicki Andrzej , Sońta Marcin , Bendowski Wiktor , Niemiec Tomasz , Zglińska Klara , Zielińska-Górska Marlena
Published: October 2023

The purpose of this study was to determine the nutritional suitability of WDGS in pigs’ feeding and production. Pigs were liquid fed and divided into 3 groups. Pigs in the control group were fed diets based on cereal grains, while the experimental groups were also given 10% or 15% WDGS, which partially replaced their cereal grains. During this study, the average daily gains (ADG), feed intake, chemical composition of meat, fatty acid profile of meat, and quality parameters of the carcass and meat were examined. The highest statistical weight gains were detected for the group WDGS 10% during the first stage of the fattening period. No statistical differences were detected for the final body weight, carcass traits, chemical composition of the meat or the composition of fatty acids such as SFAs, PUFAs, and MUFAs, with the exception of eicosenoic acid (C20:1n9). Pigs fed on 10% WDGS exhibited lower peroxidation of lipids (TBARS) than the control group or WDGS 15%. Similarly, water holding capacity (WHC) was the lowest for the group WDGS 10%. Of the meat coloration, redness (a*), yellowness (b*), and chroma (C*) were affected by the WDGS’ inclusion, where the highest values were observed for the group WDGS 10%. In conclusion, WDGS can be utilized in the liquid feeding of pigs for up to 15% of their DM.
Optimizing Indoor Hemp Cultivation Efficiency through Differential Day–Night Temperature Treatment
Authors: Bok Gwonjeong , Hahm Seungyong , Shin Juhyung , Park Jongseok
Published: October 2023

This study was conducted to determine the optimal temperature difference in day–night indoor cultivation conditions to enhance the flower yield and functional component contents of female hemp plants. Hemp clones were cultivated under five distinct day and night temperature differences (DIF) during the reproductive stage. The daytime and nighttime temperature settings were as follows: 18:30 °C (negative 12 DIF), 21:27 °C (negative 6 DIF), 24:24 °C (0 DIF), 27:21 °C (positive 6 DIF), and 30:18 °C (positive 12 DIF). Seven weeks after transplantation, the growth parameters, leaf gas exchange, total phenolic compounds, 2,2-diphenylpicrylhydrazyl scavenging activity, and cannabinoid contents were analyzed. The total shoot biomass based on dry weight was highest at 21:27, reaching 41.76 g, and lowest at 30:18, measuring 24.46 g. However, the flower biomass, which is the primary production site, was highest at 24:24 and lowest at 18:30, showing a 4.7-fold difference. The photosynthesis-related parameters were temperature-dependent and strongly correlated with biomass production. The cannabinoid content of the hemp leaves increased at 21:27, whereas that of the hemp flowers increased at 27:21. The findings of this study indicate that the optimal temperature condition for female hemp flower production in a limited space is positive 6 DIF treatment, which corresponds to 27:21 °C. These results can contribute to advancements in indoor crop cultivation technology.
Characterization of Durum Wheat Resistance against Septoria Tritici Blotch under Climate Change Conditions of Increasing Temperature and CO2 Concentration
Authors: Porras Rafael , Miguel-Rojas Cristina , Lorite Ignacio J. , Pérez-de-Luque Alejandro , Sillero Josefina C.
Published: October 2023

Wheat interactions against fungal pathogens, such as Zymoseptoria tritici, are affected by changes in abiotic factors resulting from global climate change. This situation demands in-depth knowledge of how predicted increases in temperature and CO2 concentration ([CO2]) will affect wheat—Z. tritici interactions, especially in durum wheat, which is mainly grown in areas considered to be hotspots of climate change. Therefore, we characterized the response of one susceptible and two resistant durum wheat accessions against Z. tritici under different environments in greenhouse assays, simulating the predicted conditions of elevated temperature and [CO2] in the far future period of 2070–2099 for the wheat-growing region of Córdoba, Spain. The exposure of the wheat—Z. tritici pathosystem to elevated temperature reduced disease incidence compared with the baseline weather conditions, mainly affecting pathogen virulence, especially at the stages of host penetration and pycnidia formation and maturation. Interestingly, simultaneous exposure to elevated temperature and [CO2] slightly increased Z. tritici leaf tissue colonization compared with elevated temperature weather conditions, although this fungal growth did not occur in comparison with baseline conditions, suggesting that temperature was the main abiotic factor modulating the response of this pathosystem, in which elevated [CO2] slightly favored fungal development.