bluuebunny/crossref_metadata_2025 huggingface dataset:
Why classical logic is privileged: justification of logics based on translatability
Authors: Schurz Gerhard
Published: November 2021

In Sect. 1 it is argued that systems of logic are exceptional, but not a priori necessary. Logics are exceptional because they can neither be demonstrated as valid nor be confirmed by observation without entering a circle, and their motivation based on intuition is unreliable. On the other hand, logics do not express a priori necessities of thinking because alternative non-classical logics have been developed. Section 2 reflects the controversies about four major kinds of non-classical logics—multi-valued, intuitionistic, paraconsistent and quantum logics. Its purpose is to show that there is no particular domain or reason that demands the use of a non-classical logic; the particular reasons given for the non-classical logic can also be handled within classical logic. The result of Sect. 2 is substantiated in Sect. 3, where it is shown (referring to other work) that all four kinds of non-classical logics can be translated into classical logic in a meaning-preserving way. Based on this fact a justification of classical logic is developed in Sect. 4 that is based on its representational optimality. It is pointed out that not many but a few non-classical logics can be likewise representationally optimal. However, the situation is not symmetric: classical logic has ceteris paribus advantages as a unifying metalogic, while non-classical logics can have local simplicity advantages.
Rigour versus the need for evidential diversity
Authors: Cartwright Nancy
Published: November 2021

This paper defends the need for evidential diversity and the mix of methods that that can in train require. The focus is on causal claims, especially ‘singular’ claims about the effects of causes in a specific setting—either what will happen or what has happened. I do so by offering a template that categorises kinds of evidence that can support these claims. The catalogue is generated by considering what needs to happen for a causal process to carry through from putative cause at the start to the targeted effect at the end. The usual call for mixed methods focusses on a single overall claim and argues that we increase certainty by the use of different methods with compensating strengths and weaknesses. My proposals instead focus on the evidence that supports the great many subsidiary claims that must hold if the overall one is to be true. As is typical for singular causal claims, the mix of methods that will generally be required to collect the kinds of evidence I urge will usually have little claim to the kind of rigour that is now widely demanded in evidencing causal claims, especially those for policy/treatment effectiveness. So I begin with an exploration of what seems to be intended by ‘rigour’ in such discussions, since it is seldom made clear just what makes the favoured methods especially rigorous. I then argue that the emphasis on rigour can be counterproductive. Rigour is often the enemy of evidential diversity, and evidential diversity—lots of it—can make for big improvements in the reliability of singular causal predictions and post hoc evaluations. I illustrate with the paragon of rigour for causal claims, randomised controlled trials (RCTs), rehearsing at some length what they can and cannot do to make it easier to assess the importance of rigour in warranting singular causal claims.
Action control, forward models and expected rewards: representations in reinforcement learning
Authors: Rusanen Anna-Mari , Lappi Otto , Kuokkanen Jesse , Pekkanen Jami
Published: November 2021

The fundamental cognitive problem for active organisms is to decide what to do next in a changing environment. In this article, we analyze motor and action control in computational models that utilize reinforcement learning (RL) algorithms. In reinforcement learning, action control is governed by an action selection policy that maximizes the expected future reward in light of a predictive world model. In this paper we argue that RL provides a way to explicate the so-called action-oriented views of cognitive systems in representational terms.
Allergic reaction and metal hypersensitivity after shoulder joint replacement
Authors: Pautasso A. , Zorzolo I. , Bellato E. , Pellegrino P. , Ferrario A. , Pira E. , Castoldi F.
Published: November 2021

Purpose

Metal ion release may cause local and systemic effects and induce hypersensitivity reactions. The aim of our study is first to determine if implant-related hypersensitivity correlates to patient symptoms or not; second, to assess the rate of hypersensitivity and allergies in shoulder arthroplasty.

Methods

Forty patients with shoulder replacements performed between 2015 and 2017 were studied with minimum 2-year follow-up; no patient had prior metal implants. Each patient underwent radiographic and clinical evaluation using the Constant-Murley Score (CMS), 22 metal and cement haptens patch testing, serum and urine tests to evaluate 12 metals concentration, and a personal occupational medicine interview.

Results

At follow-up (average 45 ± 10.7 months), the mean CMS was 76 ± 15.9; no clinical complications or radiographic signs of loosening were detected; two nickel sulfate (5%), 1 benzoyl peroxide (2.5%) and 1 potassium dichromate (2.5%) positive findings were found, but all these patients were asymptomatic. There was an increase in serum aluminum, urinary aluminum and urinary chromium levels of 1.74, 3.40 and 1.83 times the baseline, respectively. No significant difference in metal ion concentrations were found when patients were stratified according to gender, date of surgery, type of surgery, and type of implant.

Conclusions

Shoulder arthroplasty is a source of metal ion release and might act as a sensitizing exposure. However, patch test positivity does not seem to correlate to hypersensitivity cutaneous manifestations or poor clinical results. Laboratory data showed small constant ion release over time, regardless of gender, type of shoulder replacement and implant used.

Levels of evidence

Level II.
Methane emissions against the background of natural and mining conditions in the Budryk and Pniówek mines in the Upper Silesian Coal Basin (Poland)
Authors: Dreger Marcin , Kędzior Sławomir
Published: November 2021

The paper presents the variability of hard coal output, methane content and methane emissions into coal workings and into the atmosphere from the two most methane-gassy coal mines in Poland. The Budryk mine is one of the youngest mines in Poland, but it is the most methane-gassy as well. In 2016, the total CH4 emissions exceed 140 million of m3. This large increase in methane emissions to mine workings is primarily related to the increase in the depth of coal extraction (up to 1290 m) and, consequently, the rapid increase in the methane content in coal seams (up to 10–12 m3/Mg coaldaf). On the other hand, in the Pniówek mine, methane emission was the highest at the beginning of the study period (1986–1991). During the following years, emission decreased to the values of less than 140 million of m3, which were still one of the largest amounts of emitted methane in the entire Upper Silesian Coal Basin. The coexistence of natural factors, such as the geological structure and gas distribution, as well as mining-related factors, i.e. the depth of mining, the intensity of coal extraction determines the temporal variability of methane emissions in the studied mines.
On spectral asymptotic of quasi-exactly solvable quartic potential
Authors: Shapiro Boris , Tater Miloš
Published: November 2021

Motivated by the earlier results of Masoero and De Benedetti (Nonlinearity 23:2501, 2010) and Shapiro et al. (Commun Math Phys 311(2):277–300, 2012), we discuss below the asymptotic of the solvable part of the spectrum for the quasi-exactly solvable quartic oscillator. In particular, we formulate a conjecture on the coincidence of the asymptotic shape of the level crossings of the latter oscillator with the asymptotic shape of zeros of the Yablonskii–Vorob’ev polynomials. Further we present a numerical study of the spectral monodromy for the oscillator in question.
Commentary for Unjani clinics: meeting the need for scale through social franchising
Authors: Zeyen Anica
Published: November 2021

This commentary reflects on the social franchising model of Unjani. It discusses the intricate interwoven elements of the model which allows it to flourish. Here, I take a stewardship and social capital view to elaborate on these mechanisms. In the second part of the commentary, I highlight the limitations of the model specifically as it pertains to its potential growth.
After defeat: how governing parties respond to electoral loss
Authors: Margalit Yotam , Slough Tara , Ting Michael M.
Published: November 2021

How do governing parties respond in terms of ideological positioning when voted out of office? We study both theoretically and empirically the factors that shape parties’ responses following a loss. Studying national elections in advanced industrialized democracies over the past 70 years, we show that parties tend to counter their pre-election shifts, and do so particularly strongly following defeat. The extent of these ideological shifts is more limited in parties with a larger selectorate voting on the party leadership. Moreover, we find that subsequent to loss, parties arelesslikely to run on a centrist platform. Notably, shifting away from the center is associated with a higher probability of returning to power. We then introduce a dynamic model of party leadership selection and platform positioning. The model produces patterns of ideological positions over time that are consistent with our empirical findings.
Lower carbohydrate diets for adults with type 2 diabetes
Authors: Singh Mamta , Hung Estella S. , Cullum Adrienne , Allen Rachel E. , Aggett Peter J. , Dyson Pamela , Forouhi Nita G. , Greenwood Darren C. , Pryke Rachel , Taylor Roy , Twenefour Douglas , Waxman Ruth , Young Ian S.
Published: November 2021

Background

In May 2021, the Scientific Advisory Committee on Nutrition (SACN) published a risk assessment on lower carbohydrate diets for adults with type 2 diabetes (T2D)(1). The purpose of the report was to review the evidence on ‘low’-carbohydrate diets compared with the current UK government advice on carbohydrate intake for adults with T2D. However, since there is no agreed and widely utilised definition of a ‘low’-carbohydrate diet, comparisons in the report were between lower and higher carbohydrate diets. SACN’s remit is to assess the risks and benefits of nutrients, dietary patterns, food or food components for health by evaluating scientific evidence and to make dietary recommendations for the UK based on its assessment(2). SACN has a public health focus and only considers evidence in healthy populations unless specifically requested to do otherwise. Since the Committee does not usually make recommendations relating to clinical conditions, a joint working group (WG) was established in 2017 to consider this issue. The WG comprised members of SACN and members nominated by Diabetes UK, the British Dietetic Association, Royal College of Physicians and Royal College of General Practitioners. Representatives from NHS England and NHS Health Improvement, the National Institute for Health and Care Excellence and devolved health departments were also invited to observe the WG. The WG was jointly chaired by SACN and Diabetes UK.
CONSISTENCY AND COHERENCE IN ADJUDICATING THE ECB'S UNCONVENTIONAL MONETARY POLICY
Authors: Gerner-Beuerle Carsten , Küçük Esin
Published: November 2021

Few court cases in the history of European integration have been more controversial than the decisions of the Court of Justice of the EU and the German Federal Constitutional Court on the European Central Bank's public sector asset purchase programmes. This article regards consistency and coherence in the case law as uncontroversial minimum conditions that have to be satisfied for the decisions to gain legitimacy. It assesses the case law against this benchmark and determines the limits of asset purchase programmes under a consistent and coherent application of the legal tests developed by the courts.
AGGRESSION AND STATE RESPONSIBILITY AT THE INTERNATIONAL CRIMINAL COURT
Authors: Wong Meagan S.
Published: November 2021

The definition of the crime of aggression in Article 8bisof the Rome Statute of the International Criminal Court (Rome Statute) stipulates that a State act of aggression is a material element of the crime, suggesting an intrinsic link between individual criminal responsibility and State responsibility for aggression. This article argues that the Rome Statute provides a legal basis for the International Criminal Court (ICC) to determine State responsibility for aggression when considering the material elements of the crime of aggression, which has important practical and conceptual implications for the law of international responsibility. Although the content of State responsibility flows automatically from the breach of the obligation, it is argued that a finding of aggression pursuant to Article 8bisof the Rome Statute may be considered as a form of satisfaction for the purposes of Article 37 of the 2001 ILC Articles on Responsibility of States for Internationally Wrongful Acts (2001 ILC Articles). Furthermore, the material element of the crime in Article 8bisof the Rome Statute requires the act of aggression by its character, gravity, and scale to constitute a manifest violation of the Charter of the United Nations, in line with the nomenclature used within the 2001 ILC Articles regarding serious breaches of obligations arising from peremptory norms of general international law (jus cogens). The article considers the important role that the ICC may play in relation to serious breaches of thejus cogensobligation to refrain from an act of aggression.
Bulbs Onstage: Theatrical Hygiene and the Electrification of Performance
Authors: OTTO ULF
Published: November 2021

European theatres were electrified between 1883 and 1913. This process has traditionally been associated with the advent of modernist theatre, but the details have rarely been examined, nor has the scope of the process's social and technological impacts been analysed. Reconstructing light bulbs’ early appearances in theatrical practice and discourse, this article traces the intricate entanglement between the electrical industry and theatrical culture around the turn of the century and highlights electricity's entanglement with concepts of hygiene and healing. Discussing an early light bulb in use in Bayreuth in 1882, the marketing strategies of the German Edison Company and Adolphe Appia's early manifesto, the article shows how electrification of theatres was shaped by competing visions of a future theatre. Also it demonstrates that aesthetics, technology and politics were intricately entangled in this process. Refuting teleological narratives of aesthetic progress, the paper proposes reframing modernist theatre's artistic autonomy as dependent on its embeddedness within the technologies of modernity.
Radiation Path of Diurnal Internal Tides in the Northwestern Pacific Controlled by Refraction and Interference
Authors: Wang Yang , Xu Zhenhua , Hibiya Toshiyuki , Yin Baoshu , Wang Fan
Published: November 2021

The diurnal internal tides contribute nearly a quarter of global baroclinic tidal energy. However, their roles in shaping the spatiotemporal inhomogeneity of the tidal energy field are not well known. Based on observation‐supported numerical simulation and theoretical analyses, we clarify the combined and relative contributions of β refraction, subtidal circulation refraction and multiwave interference to the long‐range radiation and dissipation maps of diurnal internal tides in the northwestern Pacific. The diurnal tidal beams primarily emanate from the Luzon Strait (LS) and Talaud‐Halmahera Passage (THP). The β refraction shifts the mean path of the LS tidal beam equatorward by ∼40° when it arrives at the deep basin. This is consistent with previous altimetric observations. A second refraction effect by subtidal circulation with seasonal variability deflects the mean beam path by ∼10°. Multiwave interference of the tidal beams from the LS and THP further enhances the inhomogeneous pattern. It enhances or reduces the energy fluxes of the tidal beams with distinct vertical structures in the western Mariana basin. A modified line‐source model and theoretical ray‐tracing analysis explain the effects of refraction and interference well. The internal tidal dissipation map in the deep basin coincides well with the inhomogeneous and spreading radiation paths. The characterization of the world's most energetic diurnal internal tides in the northwestern Pacific could improve our understanding of global baroclinic tidal energy redistribution and tidal mixing geography.
A Safety Factor Approach to Designing Urban Infrastructure for Dynamic Conditions
Authors: Sharma Sanjib , Lee Ben Seiyon , Nicholas Robert E. , Keller Klaus
Published: November 2021

Current approaches to design flood‐sensitive infrastructure typically assume a stationary rainfall distribution and neglect many uncertainties. These assumptions are inconsistent with observations that suggest intensifying extreme precipitation events and the uncertainties surrounding projections of the coupled natural‐human systems. Here we demonstrate a safety factor approach to designing urban infrastructure in a changing climate. Our results show that assuming climate stationarity and neglecting deep uncertainties can drastically underestimate flood risks and lead to poor infrastructure design choices. We find that climate uncertainty dominates the socioeconomic and engineering uncertainties that impact the hydraulic reliability in stormwater drainage systems. We quantify the upfront costs needed to achieve higher hydraulic reliability and robustness against the deep uncertainties surrounding projections of rainfall, surface runoff characteristics, and infrastructure lifetime. Depending on the location, we find that adding safety factors of 1.4–1.7 to the standard stormwater pipe design guidance produces robust performance to the considered deep uncertainties. The insights gained from this study highlights the need for updating traditional engineering design strategies to improve infrastructure reliability under socioeconomic and environmental changes.
Fluid Invasion Dynamics in Porous Media With Complex Wettability and Connectivity
Authors: Mascini Arjen , Boone Marijn , Van Offenwert Stefanie , Wang Shan , Cnudde Veerle , Bultreys Tom
Published: November 2021

Multiphase flow is important for many natural and engineered processes in subsurface geoscience. Pore‐scale multiphase flow dynamics are commonly characterized by an average balance of driving forces. However, significant local variability in this balance may exist inside natural, heterogeneous porous materials, such as rocks and soils. Here, we investigate multiphase flow in heterogeneous rocks with different wetting properties using fast laboratory‐based 4D X‐ray imaging. The mixed‐wet dynamics were characterized by displacement rates that differed over orders of magnitude between directly neighboring pores. While conventional understanding predicted strongly capillary‐dominated conditions, our analysis suggests that viscous forces played a key role in these dynamics, facilitated by a complex interplay between the mixed‐wettability and the pore structure. These dynamics highlight the need for further studies on the fundamental controls on multiphase flow in geomaterials, which is crucial to design, for example, groundwater remediation and subsurface CO2 storage operations.
Regional Characteristics of Variability in the Northern Hemisphere Wintertime Polar Front Jet and Subtropical Jet in Observations and CMIP6 Models
Authors: Liu Xinhuiyu , Grise Kevin M. , Schmidt Daniel F. , Davis Robert E.
Published: November 2021

Variability in the position and strength of the subtropical jet (STJ) and polar front jet (PFJ) streams has important implications for global and regional climate. Previous studies have related the position and strength of the STJ to tropical thermodynamic processes, whereas the position and strength of the PFJ are more associated with midlatitude eddies. These conclusions have largely resulted from studies using idealized models. In this study, ERA‐Interim reanalysis and CMIP6 global climate models are used to examine month‐to‐month and interannual variability of the wintertime Northern Hemisphere (NH) STJ and PFJ. This study particularly focuses on the regional characteristics of the jet variability, extending previous studies on zonal‐mean jet streams. Consistent with idealized modeling studies, a close relationship is found between tropical outgoing longwave radiation (OLR) and the STJ and between midlatitude lower tropospheric temperature gradients and the PFJ. Variations of both jets are also linked to well‐known teleconnection patterns. Variations in tropical convection over the Pacific Ocean are associated with variations of the NH STJ at most longitudes, with different phases of the El Niño–Southern Oscillation (ENSO) associated with the shift and strengthening of the STJ in different regions. CMIP6 models generally capture these relationships, but the models’ tropical convection is often displaced westward when compared to observations, reflecting a climatological bias in OLR in the western tropical Pacific Ocean in many models. The displaced tropical convection in models excites different paths of Rossby wave propagation, resulting in different ENSO teleconnections on the STJ over North America and Europe.
Investigating Sources of Spectral Olivine Enrichments in Martian Bedrock Plains Using Diurnal Emissivity Changes in THEMIS Multispectral Images
Authors: Cowart J. C. , Rogers A. D.
Published: November 2021

We investigate spectral olivine detections in the Noachian cratered highlands that are spatially associated with flat bedrock exposures. Strong olivine detections were previously attributed to relatively high (∼10%–15%) modal abundances of olivine in the bedrock, and then later hypothesized to instead originate from a patchy cover of olivine‐rich sediment formed from erosional lag deposits and mineral‐specific comminution/transport. We test these hypotheses by developing a new technique to partially separate the spectral signals of bedrock and unconsolidated surficial sediment. It uses the differing thermophysical properties of sand and indurated materials, which change the relative contributions of these materials to the emitted spectrum over the diurnal cycle. We use multispectral Mars Odyssey Thermal Emission Imaging System (THEMIS) observations collected in the mid‐afternoon and early evening to apply this technique to eight Terra Sabaea bedrock plains and the Nili Fossae olivine‐carbonate plain. Significant changes in spectral shape arising from compositional differences between bedrock and sediment cover are observed in four bedrock plains. Where these differences are observed, the spectral changes are consistent decreased olivine abundance in the sediment fraction, rather than increased as previously hypothesized. Our results indicate that bedrock materials in the Terra Sabaea region are olivine‐rich in composition, likely indicating a pyroclastic origin for these materials.
Proterozoic to Phanerozoic Tectonism in Southwestern Montana Basement Ranges Constrained by Low Temperature Thermochronometric Data
Authors: Kaempfer Jenna M. , Guenthner William R. , Pearson David M.
Published: November 2021

Crystalline basement rocks of southwestern Montana have been subjected to multiple tectonothermal events since ∼3.3 Ga: the Paleoproterozoic Big Sky/Great Falls orogeny, Mesoproterozoic extension associated with Belt‐Purcell basin formation, Neoproterozoic extension related to Rodinia rifting, and the late Phanerozoic Sevier‐Laramide orogeny. We investigated the long‐term (>1 Ga), low‐temperature (erosion/burial within 10 km of the surface) thermal histories of these tectonic events with zircon and apatite (U‐Th)/He thermochronology. Data were collected across nine sample localities (n = 55 zircon and n = 26 apatite aliquots) in the northern and southern Madison ranges, the Blacktail‐Snowcrest arch, and the Tobacco Root uplift. Our zircon (U‐Th)/He data show negative trends between single aliquot date and effective uranium (a radiation damage proxy), which we interpreted with a thermal history model that considers the damage‐He diffusivity relationship in zircon. Our model results for these basement ranges show substantial cooling from temperatures above 400°C to near surface conditions between 800 and 510 Ma. Subsequent Phanerozoic exhumation culminated by ∼75 Ma. Late Phanerozoic cooling is coincident with along‐strike Sevier belt thin‐skinned thrusting in southeastern Idaho, and older than exhumation in basement‐involved uplifts of the Wyoming Laramide province. Our long‐term, low‐temperature thermal record for these southwestern Montana basement ranges shows that: (a) these basement blocks have experienced multiple episodes of upper crustal exhumation and burial since Archean time, possibly influencing Phanerozoic thrust architecture and (b) the late Phanerozoic thick‐skinned thrusting recorded by these rocks is among the earliest thermochronologic records of Laramide basement‐involved shortening and was concomitant with Sevier belt thin‐skinned thrusting.
Different Couplings Between Precipitation and Deformation at the Same Site: A Case Study at Central Pyrenees (Spain)
Authors: Amoruso Antonella , Crescentini Luca , Costa Riccardo
Published: November 2021

Impact of hydrology‐associated deformation spans from the study of the rock hydrological properties and aquifer dynamics to the identification of geological disaster precursors. We analyze a comprehensive set of hydrology‐associated deformation signals, recorded by two underground 70 m long strainmeters (GAL16 and LAB780) operating under the Central Pyrenees (Spain) from the end of 2011 to the end of 2018. The two strainmeters measure extensional strain at the picostrain (10−12) level along two nearly orthogonal horizontal directions. Sign (compression or extension along any of the two directions), size, and time evolution of hydrology‐associated deformation vary considerably from season to season. We identify four classes of signals, related to summer rainfalls (producing compression along both GAL16 and LAB780), late‐spring and autumn rainfalls (producing extension along GAL16 and compression along LAB780), snow melting (producing opposite diurnal cycles along GAL16 and LAB780), and winter snowfalls (producing extension along both GAL16 and LAB780). Similar precipitations of the same class can give rise to differently sized signals; differences may be due to infiltration and/or surface load inhomogeneities as well as to complexities of the underground hydrogeological set up, which can lead to nonlinear, intrinsically time‐dependent, responses. Our modeling sheds light on the diverse effects associated with different environmental conditions. The variety of hydrology‐associated deformation we report is warning for the interpretation of all kinds of deformation data, as for their difficult modeling, the causative physical mechanisms, and the extreme care that is needed when removing hydrologically induced effects. Our insights are particularly useful in mountain areas.
High-quality reference genome and annotation aids understanding of berry development for evergreen blueberry (Vaccinium darrowii)
Authors: Yu Jiali , Hulse-Kemp Amanda M. , Babiker Ebrahiem , Staton Margaret
Published: November 2021

Vaccinium darrowiiCamp (2n = 2x = 24) is a native North American blueberry species and an important source of traits such as low chill requirement in commercial southern highbush blueberry breeding (Vaccinium corymbosum, 2n = 4x = 48). We present a chromosomal-scale genome ofV. darrowiigenerated by the combination of PacBio sequencing and high throughput chromatin conformation capture (Hi–C) scaffolding technologies, yielding a total length of 1.06 Gigabases (Gb). Over 97.8% of the genome sequences are scaffolded into 24 chromosomes representing the two haplotypes. The primary haplotype assembly ofV. darrowiicontains 34,809 protein-coding genes. Comparison to aV. corymbosumhaplotype assembly reveals high collinearity between the two genomes with small intrachromosomal rearrangements in eight chromosome pairs. With small RNA sequencing, the annotation was further expanded to include more than 200,000 small RNA loci and 638 microRNAs expressed in berry tissues. Transcriptome analysis across fruit development stages indicates that genes involved in photosynthesis are downregulated, while genes involved in flavonoid and anthocyanin biosynthesis are significantly increased at the late stage of berry ripening. A high-quality reference genome and accompanying annotation ofV. darrowiiis a significant new resource for assessing the evergreen blueberry contribution to the breeding of southern highbush blueberries.
Characterization of germline development and identification of genes associated with germline specification in pineapple
Authors: Zhao Lihua , Liu Liping , Liu Yanhui , Dou Xianying , Cai Hanyang , Aslam Mohammad , Hou Zhimin , Jin Xingyue , Li Yi , Wang Lulu , Zhao Heming , Wang Xiaomei , Sicard Adrien , Qin Yuan
Published: November 2021

Understanding germline specification in plants could be advantageous for agricultural applications. In recent decades, substantial efforts have been made to understand germline specification in several plant species, including Arabidopsis, rice, and maize. However, our knowledge of germline specification in many agronomically important plant species remains obscure. Here, we characterized the female germline specification and subsequent female gametophyte development in pineapple using callose staining, cytological, and whole-mount immunolocalization analyses. We also determined the male germline specification and gametophyte developmental timeline and observed male meiotic behavior using chromosome spreading assays. Furthermore, we identified 229 genes that are preferentially expressed at the megaspore mother cell (MMC) stage during ovule development and 478 genes that are preferentially expressed at the pollen mother cell (PMC) stage of anther development using comparative transcriptomic analysis. The biological functions, associated regulatory pathways and expression patterns of these genes were also analyzed. Our study provides a convenient cytological reference for exploring pineapple germline development and a molecular basis for the future functional analysis of germline specification in related plant species.
Spontaneous dynamical disordering of borophenes in MgB2 and related metal borides
Authors: Li Sichi , Gunda Harini , Ray Keith G. , Wong Chun-Shang , Xiao Penghao , Friddle Raymond W. , Liu Yi-Sheng , Kang ShinYoung , Dun Chaochao , Sugar Joshua D. , Kolasinski Robert D. , Wan Liwen F. , Baker Alexander A. , Lee Jonathan R. I. , Urban Jeffrey J. , Jasuja Kabeer , Allendorf Mark D. , Stavila Vitalie , Wood Brandon C.
Published: November 2021

Layered boron compounds have attracted significant interest in applications from energy storage to electronic materials to device applications, owing in part to a diversity of surface properties tied to specific arrangements of boron atoms. Here we report the energy landscape for surface atomic configurations of MgB2 by combining first-principles calculations, global optimization, material synthesis and characterization. We demonstrate that contrary to previous assumptions, multiple disordered reconstructions are thermodynamically preferred and kinetically accessible within exposed B surfaces in MgB2 and other layered metal diborides at low boron chemical potentials. Such a dynamic environment and intrinsic disordering of the B surface atoms present new opportunities to realize a diverse set of 2D boron structures. We validated the predicted surface disorder by characterizing exfoliated boron-terminated MgB2 nanosheets. We further discuss application-relevant implications, with a particular view towards understanding the impact of boron surface heterogeneity on hydrogen storage performance.
Electrically switchable van der Waals magnon valves
Authors: Chen Guangyi , Qi Shaomian , Liu Jianqiao , Chen Di , Wang Jiongjie , Yan Shili , Zhang Yu , Cao Shimin , Lu Ming , Tian Shibing , Chen Kangyao , Yu Peng , Liu Zheng , Xie X. C. , Xiao Jiang , Shindou Ryuichi , Chen Jian-Hao
Published: November 2021

Van der Waals magnets have emerged as a fertile ground for the exploration of highly tunable spin physics and spin-related technology. Two-dimensional (2D) magnons in van der Waals magnets are collective excitation of spins under strong confinement. Although considerable progress has been made in understanding 2D magnons, a crucial magnon device called the van der Waals magnon valve, in which the magnon signal can be completely and repeatedly turned on and off electrically, has yet to be realized. Here we demonstrate such magnon valves based on van der Waals antiferromagnetic insulator MnPS3. By applying DC electric current through the gate electrode, we show that the second harmonic thermal magnon (SHM) signal can be tuned from positive to negative. The guaranteed zero crossing during this tuning demonstrates a complete blocking of SHM transmission, arising from the nonlinear gate dependence of the non-equilibrium magnon density in the 2D spin channel. Using the switchable magnon valves we demonstrate a magnon-based inverter. These results illustrate the potential of van der Waals anti-ferromagnets for studying highly tunable spin-wave physics and for application in magnon-base circuitry in future information technology.
Directed nickel-catalyzed regio- and diastereoselective arylamination of unactivated alkenes
Authors: Xie Leipeng , Wang Shenghao , Zhang Lanlan , Zhao Lei , Luo Chun , Mu Linping , Wang Xiuguang , Wang Chao
Published: November 2021

Few methods have been reported for intermolecular arylamination of alkenes, which could provide direct access to important arylethylamine scaffolds. Herein, we report an intermolecular syn-1,2-arylamination of unactivated alkenes with arylboronic acids and O-benzoylhydroxylamine electrophiles with Ni(II) catalyst. The cleavable bidentate picolinamide directing group facilitates formation of stabilized 4-, 5- or 6-membered nickelacycles and enables the difunctionalization of diverse alkenyl amines with high levels of regio-, chemo- and diastereocontrol. This general and practical protocol is compatible with broad substrate scope and high functional group tolerance. The utility of this method is further demonstrated by the site-selective modification of pharmaceutical agents.
Dynamic interactions and Ca2+-binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seeding
Authors: Moreira Guilherme G. , Cantrelle François-Xavier , Quezada Andrea , Carvalho Filipa S. , Cristóvão Joana S. , Sengupta Urmi , Puangmalai Nicha , Carapeto Ana P. , Rodrigues Mário S. , Cardoso Isabel , Fritz Güenter , Herrera Federico , Kayed Rakez , Landrieu Isabelle , Gomes Cláudio M.
Published: November 2021

The microtubule-associated protein tau is implicated in the formation of oligomers and fibrillar aggregates that evade proteostasis control and spread from cell-to-cell. Tau pathology is accompanied by sustained neuroinflammation and, while the release of alarmin mediators aggravates disease at late stages, early inflammatory responses encompass protective functions. This is the case of the Ca2+-binding S100B protein, an astrocytic alarmin which is augmented in AD and which has been recently implicated as a proteostasis regulator, acting over amyloid β aggregation. Here we report the activity of S100B as a suppressor of tau aggregation and seeding, operating at sub-stoichiometric conditions. We show that S100B interacts with tau in living cells even in microtubule-destabilizing conditions. Structural analysis revealed that tau undergoes dynamic interactions with S100B, in a Ca2+-dependent manner, notably with the aggregation prone repeat segments at the microtubule binding regions. This interaction involves contacts of tau with a cleft formed at the interface of the S100B dimer. Kinetic and mechanistic analysis revealed that S100B inhibits the aggregation of both full-length tau and of the microtubule binding domain, and that this proceeds through effects over primary and secondary nucleation, as confirmed by seeding assays and direct observation of S100B binding to tau oligomers and fibrils. In agreement with a role as an extracellular chaperone and its accumulation near tau positive inclusions, we show that S100B blocks proteopathic tau seeding. Together, our findings establish tau as a client of the S100B chaperone, providing evidence for neuro-protective functions of this inflammatory mediator across different tauopathies.
Ferroelectric 2D ice under graphene confinement
Authors: Chin Hao-Ting , Klimes Jiri , Hu I-Fan , Chen Ding-Rui , Nguyen Hai-Thai , Chen Ting-Wei , Ma Shao-Wei , Hofmann Mario , Liang Chi-Te , Hsieh Ya-Ping
Published: November 2021

We here report on the direct observation of ferroelectric properties of water ice in its 2D phase. Upon nanoelectromechanical confinement between two graphene layers, water forms a 2D ice phase at room temperature that exhibits a strong and permanent dipole which depends on the previously applied field, representing clear evidence for ferroelectric ordering. Characterization of this permanent polarization with respect to varying water partial pressure and temperature reveals the importance of forming a monolayer of 2D ice for ferroelectric ordering which agrees with ab-initio and molecular dynamics simulations conducted. The observed robust ferroelectric properties of 2D ice enable novel nanoelectromechanical devices that exhibit memristive properties. A unique bipolar mechanical switching behavior is observed where previous charging history controls the transition voltage between low-resistance and high-resistance state. This advance enables the realization of rugged, non-volatile, mechanical memory exhibiting switching ratios of 106, 4 bit storage capabilities and no degradation after 10,000 switching cycles.
Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole
Authors: Neuberger Arthur , Nadezhdin Kirill D. , Sobolevsky Alexander I.
Published: November 2021

TRPV6 is a calcium-selective ion channel implicated in epithelial Ca2+ uptake. TRPV6 inhibitors are needed for the treatment of a broad range of diseases associated with disturbed calcium homeostasis, including cancers. Here we combine cryo-EM, calcium imaging, and mutagenesis to explore molecular bases of human TRPV6 inhibition by the antifungal drug econazole and the universal ion channel blocker ruthenium red (RR). Econazole binds to an allosteric site at the channel’s periphery, where it replaces a lipid. In contrast, RR inhibits TRPV6 by binding in the middle of the ion channel’s selectivity filter and plugging its pore like a bottle cork. Despite different binding site locations, both inhibitors induce similar conformational changes in the channel resulting in closure of the gate formed by S6 helices bundle crossing. The uncovered molecular mechanisms of TRPV6 inhibition can guide the design of a new generation of clinically useful inhibitors.
Underrepresented patient views and perceptions of personalized medication treatment through pharmacogenomics
Authors: Saulsberry Loren , Danahey Keith , Borden Brittany A. , Lipschultz Elizabeth , Traore Maimouna , Ratain Mark J. , Meltzer David O. , O’Donnell Peter H.
Published: November 2021

Within an institutional pharmacogenomics implementation program, we surveyed 463 outpatients completing preemptive pharmacogenomic testing whose genetic results were available to providers for guiding medication treatment. We compared views and experiences from self-reported White and Black patients, including education level as a covariate across analyses. Black patients were less confident about whether their providers made personalized treatment decisions, and overwhelmingly wanted a greater role for their genetic information in clinical care. Both groups similarly reported that providers asked their opinions regarding medication changes, but White patients were more likely (59% vs. 49%,P = 0.005) to discuss the impact of personal/genetic makeup on medication response with providers, and Black patients reported initiating such discussions much less frequently (4% vs. 15%,P = 0.037). Opportunities exist for enhanced communication with underrepresented patients around personalized care. Tailored communication strategies and development of support tools employed in diverse healthcare settings may facilitate pharmacogenomically guided medication treatment that equitably benefits minority patient populations.
Attributes of the food and physical activity built environments from the Southern Cone of Latin America
Authors: Gutierrez Laura E. , Elorriaga Natalia , Gibbons Luz , Melendi Santiago , Chaparro Martín , Calandrelli Matías , Lanas Fernando , Mores Nora , Ponzo Jacqueline , Poggio Rosana , Berrueta Mabel , Irazola Vilma
Published: November 2021

Previous studies have shown the influence of the physical and social environments on the development of obesity and non-communicable diseases (NCD). An obesogenic environment promotes higher dietary energy intakes and sedentary behaviors while limiting opportunities or incentives for active living. This paper presents a dataset with key attributes of the food and physical activity built environment, including green spaces, quality of streets and sidewalks, and different types of food retail outlets in four cities of the Southern Cone of Latin America. A total of 139 representative neighborhoods randomly selected from: Marcos Paz and Bariloche (Argentina), Temuco (Chile) and Canelones-Barros Blancos (Uruguay) were evaluated, where standardized community walks were conducted for direct observation of the built environment. This dataset will contribute valuable data to the evaluation of obesogenic environments in the region, and could be linked to additional ecological information about risk factors for NCDs and socio-economic features from other sources. Understanding environmental influences on cardiovascular risk factors and individual habits may help explain NCD outcomes and plan urban policies.
Assessing cost-effectiveness of hepatitis C testing pathways in Georgia using the Hep C Testing Calculator
Authors: Adee Madeline , Zhuo Yueran , Zhong Huaiyang , Zhan Tiannan , Aggarwal Rakesh , Shilton Sonjelle , Chhatwal Jagpreet
Published: November 2021

The cost of testing can be a substantial contributor to hepatitis C virus (HCV) elimination program costs in many low- and middle-income countries such as Georgia, resulting in the need for innovative and cost-effective strategies for testing. Our objective was to investigate the most cost-effective testing pathways for scaling-up HCV testing in Georgia. We developed a Markov-based model with a lifetime horizon that simulates the natural history of HCV, and the cost of detection and treatment of HCV. We then created an interactive online tool that uses results from the Markov-based model to evaluate the cost-effectiveness of different HCV testing pathways. We compared the current standard-of-care (SoC) testing pathway and four innovative testing pathways for Georgia. The SoC testing was cost-saving compared to no testing, but all four new HCV testing pathways further increased QALYs and decreased costs. The pathway with the highest patient follow-up, due to on-site testing, resulted in the highest discounted QALYs (124 QALY more than the SoC) and lowest costs ($127,052 less than the SoC) per 10,000 persons screened. The current testing algorithm in Georgia can be replaced with a new pathway that is more effective while being cost-saving.
Understanding the physicochemical properties of Zn–Fe LDH nanostructure as sorbent material for removing of anionic and cationic dyes mixture
Authors: Mahmoud Rehab K. , Taha Mohamed , Zaher Amal , Amin Rafat M.
Published: November 2021

In our work, the removal of cationic and anionic dyes from water was estimated both experimentally and computationally. We check the selectivity of the adsorbent, Zn–Fe layered double hydroxide (LDH) toward three dyes. The physical and chemical properties of the synthesis adsorbent before and after the adsorption process were investigated using X-ray photoelectron spectroscopy, energy dispersive X-ray, X-ray diffraction, FT-IR, HRTEM, and FESEM analysis, particle size, zeta potential, optical and electric properties were estimated. The effect of pH on the adsorption process was estimated. The chemical stability was investigated at pH 4. Monte Carlo simulations were achieved to understand the mechanism of the adsorption process and calculate the adsorption energies. Single dye adsorption tests revealed that Zn–Fe LDH effectively takes up anionic methyl orange (MO) more than the cationic dyes methylene blue (MB) and malachite green (MG). From MO/MB/MG mixture experiments, LDH selectively adsorbed in the following order: MO > MB > MG. The adsorption capacity of a single dye solution was 230.68, 133.29, and 57.34 mg/g for MO, MB, and MG, respectively; for the ternary solution, the adsorption capacity was 217.97, 93.122, and 49.57 mg/g for MO, MB, and MG, respectively. Zn–Fe LDH was also used as a photocatalyst, giving 92.2% and 84.7% degradation at concentrations of 10 and 20 mg/L, respectively. For visible radiation, the Zn–Fe LDH showed no activity.
From machine learning to transfer learning in laser-induced breakdown spectroscopy analysis of rocks for Mars exploration
Authors: Sun Chen , Xu Weijie , Tan Yongqi , Zhang Yuqing , Yue Zengqi , Zou Long , Shabbir Sahar , Wu Mengting , Chen Fengye , Yu Jin
Published: November 2021

With the ChemCam instrument, laser-induced breakdown spectroscopy (LIBS) has successively contributed to Mars exploration by determining the elemental compositions of soils, crusts, and rocks. The American Perseverance rover and the Chinese Zhurong rover respectively landed on Mars on February 18 and May 15, 2021, further increase the number of LIBS instruments on Mars. Such an unprecedented situation requires a reinforced research effort on the methods of LIBS spectral data analysis. Although the matrix effects correspond to a general issue in LIBS, they become accentuated in the case of rock analysis for Mars exploration, because of the large variation of rock compositions leading to the chemical matrix effect, and the difference in surface physical properties between laboratory standards (in pressed powder pellet, glass or ceramic) used to establish calibration models and natural rocks encountered on Mars, leading to the physical matrix effect. The chemical matrix effect has been tackled in the ChemCam project with large sets of laboratory standards offering a good representation of various compositions of Mars rocks. The present work more specifically deals with the physical matrix effect which is still lacking a satisfactory solution. The approach consists in introducing transfer learning in LIBS data treatment. For the specific application of total alkali-silica (TAS) classification of rocks (either with a polished surface or in the raw state), the results show a significant improvement in the ability to predict of pellet-based models when trained together with suitable information from rocks in a procedure of transfer learning. The correct TAS classification rate increases from 25% for polished rocks and 33.3% for raw rocks with a machine learning model, to 83.3% with a transfer learning model for both types of rock samples.