bluuebunny/crossref_metadata_2025 huggingface dataset:
Hoàn thiện quy định pháp luật bảo đảm xử lý tài sản thế chấp là nhà ở
Authors: Huỳnh Văn Chữ
Published: May 2023

Thế chấp nhà ở để bảo đảm thực hiện nghĩa vụ, nhất là nghĩa vụ trả nợ là giao dịch phổ biến ở nước ta hiện nay. Thông thường các chủ thể thế chấp sẽ cố gắng trả nợ, tuy nhiên không ít trường hợp vì các lý do khác nhau mà không thực hiện đúng cam kết, dẫn đến phải xử lý tài sản bảo đảm là nhà ở. Việc xử lý thế chấp nhà ở, bên cạnh những thuận lợi còn tồn tại không ít vụ việc phức tạp, việc xử lý khác nhau, thậm chí xử lý không đúng quy định. Bài viết khái quát sự điều chỉnh pháp luật Việt Nam về xử lý thế chấp tài sản là nhà ở; thực tiễn việc xử lý tài sản thế chấp là nhà ở và đề xuất một số giải pháp hoàn thiện .
Phòng, chống gian lận trong kinh doanh bảo hiểm
Authors: Nguyễn Quốc Phú , Nguyễn Phương Anh
Published: May 2023

Trong bài viết này, tác giả phân tích những vấn đề liên quan đến gian lận trong kinh doanh bảo hiểm và đề xuất kiến nghị hoàn thiện quy định pháp luật liên quan đến hành vi gian lận trong kinh doanh bảo hiểm; phát huy vai trò của doanh nghiệp bảo hiểm và các cơ quan chức năng trong việc giám sát, ngăn ngừa hành vi gian lận của các chủ thể tham gia kinh doanh gia bảo hiểm; từ đó xử lý kịp thời, hiệu quả các hành vi gian lận bảo hiểm, bảo đảm quyền và lợi ích hợp pháp của các chủ thể trong quan hệ bảo hiểm.
Hợp tác quốc tế trong đào tạo, bồi dưỡng lực lượng Công an nhân dân
Authors: Trần Thư Anh
Published: May 2023

Trong xu thế phát triển của giáo dục hiện nay, hợp tác quốc tế trong đào tạo, bồi dưỡng và nghiên cứu khoa học đang diễn ra như một tất yếu khách quan và ngày càng khẳng định vai trò quan trọng trong quá trình phát triển nguồn nhân lực của đất nước nói chung và của lực lượng Công an nói riêng. Bài viết tổng kết một số kết quả đạt được, chỉ ra những hạn chế, bất cập của công tác hợp tác quốc tế trong đào tạo, bồi dưỡng lực lượng Công an, từ đó, đưa ra một số đề xuất, kiến nghị nhằm nâng cao chất lượng công tác này trong thời gian tới.
Cơ chế, chính sách phát triển du lịch làng nghề ở vùng đồng bằng sông Cửu Long
Authors: Vũ Đình Thuận
Published: May 2023

Cơ chế, chính sách có vai trò rất quan trọng trong phát triển du lịch làng nghề ở các vùng miền trên cả nước. Thời gian qua, vùng đồng bằng sông Hồng đã có nhiều chủ trương, chính sách để phát triển du lịch làng nghề, tuy nhiên, thực trạng phát triển chưa tương xứng với tiềm năng và vị thế. Trên cơ sở phân tích, chỉ ra những hạn chế, bất cập, bài viết đề xuất một số giải pháp nhằm hoàn thiện cơ chế, chính sách phát triển du lịch làng nghề vùng đồng bằng sông Hồng trong thời gian tới.
Las relationes ad limina de los obispos tudenses (1593-1927). Una fuente vaticana para la historia de la Iglesia gallega
Authors: HERNÁNDEZ FIGUEIREDO JOSÉ RAMÓN
Published: May 2023

En este artículo se estudian veintiocho informes ad limina elaborados y presentados en la Congregación del Concilio y en la Congregación Consistorial, en sus respectivos períodos, por los obispos de la Diócesis de Tui. Se trata de una fuente documental rica en datos sobre el estado material y espiritual de la Diócesis gallega entre los siglos XVI y XX. Presenta información sobre los pontificados, el clero, la vida consagrada masculina y femenina, el pueblo de Dios, las costumbres y la vida cristiana.
El cardenal Juan Alfonso de Mella y su vinculación a obras artísticas en Roma y Zamora en el siglo XV
Authors: RIVERA DE LAS HERAS JOSÉ ÁNGEL
Published: May 2023

Juan Alfonso de Mella es un personaje destacado del siglo XV, tanto en el reino de Castilla como en la Santa Sede. Todavía no se ha realizado un estudio monográfico sobre su figura. En este artículo se sintetiza su biografía y se destacan dos obras a él vinculadas: su monumento funerario en la Iglesia de Santiago de los Españoles en Roma y la capilla de San Ildefonso de la catedral de Zamora.
Gil Sánchez Muñoz y Liñán, un testigo de excepción en el Cisma de Occidente. Su declaración en 1379 ante el rey de la Corona de Aragón
Authors: SERRA ESTELLÉS XAVIER
Published: May 2023

Gil Sánchez Muñoz, de familia noble de Teruel, canónigo paborde de Valencia, tío de su homónimo que posteriormente será el papa Clemente VIII, embajador de Gregorio XI, se encontraba en Roma en el momento de la muerte del pontífice y en el controvertido cónclave del que salió elegido Urbano VI (abril 1378), con quien inicialmente mantuvo una muy estrecha relación. Sin embargo, ya en septiembre de 1379 en las declaraciones ante Pedro IV, rey de la Corona de Aragón, que aquí trasladamos en edición crítica, ya se muestra firme partidario de Clemente VII.
Cayetano y la controversia inmaculista
Authors: DOMÍNGUEZ ASENSIO JOSÉ ARTURO
Published: May 2023

A partir del siglo XIV la controversia entre maculistas e inmaculistas se había radicalizado de forma que ambas posiciones no vacilaban en lanzarse mutuamente acusaciones de herejía. León X quiso zanjar la cuestión en el concilio V lateranense y a tal efecto encargó a Cayetano un votum. La intervención de Cayetano es un prodigio de sensatez teológica y de moderación. Maculista convencido, elabora conceptualmente la idea del debitum para mostrar que la tesis inmaculista no era contraria a la fe. La definición dogmática de la pía creencia no le resta valor al tratado de Cayetano. El lector encontrará en él criterios para hacer de la Mariología una disciplina seriamente teológica y no una hipertrofia mariológica fruto de impulsos emocionales. Y podrá comprobar la deficiencia de Cayetano en este punto: ignoró el valor del sensus fidei del pueblo cristiano e infravaloró la lex orandi como fuente teológica.
El herrero Yosef Bitón / Alonso de Palencia y la catedral de Segovia: una relación singular (c.1472-c.1530)
Authors: BARTOLOMÉ HERRERO BONIFACIO
Published: May 2023

En este artículo se aborda la figura del herrero judío Yosef Bitón, conocido como Alonso de Palencia tras su conversión al cristianismo después de 1492. Sus casi seis décadas de servicio a la catedral de Segovia suponen un excepcional hilo conductor que permite acercarse a su biografía, al trabajo de la forja y el hierro en esta ciudad castellana a fines de la edad media y a la actividad cotidiana en la catedral en torno al año 1500.
Determination of Changes in Nutritional Elements and Antioxidant Amounts in the Plant by Application of Heavy Metals (Cu, Pb, Cd) to Corn Plant (Zea Mays L.)
Authors: Sahin Sezer , Kısa Dursun , Ataklı Seda Bice
Published: May 2023

Excess of some heavy metals as copper lead and cadmium are significant contaminants for agricultural soils, and they affect plant life cycles by changing their defense enzymes and mineral element contents. This study was aimed to determine the effects of copper, lead and cadmium (Cu, Pb, and Cd) on the mineral concentration and antioxidant, enzymes activities in root and leaves of corn. They changed mineral elements content in roots and leaves of plants. Cd and Pb levels increased depending on applied doses in growth medium. Pb and Cd treatment showed harmful effect by limiting uptake of nutrients to the roots. Cu application increased ascorbate peroxidase (APX), catalase (CAT), peroxidase (POD) and superoxide dismutase (SOD) activities in the plant roots; whereas Pb increased APX activity and Cd increased both SOD and APX activities. Their applications decreased enzyme activities in leaves compared to control. This study showed that Cd has limited the level of calcium, copper, iron, magnesium, manganese, and zinc in roots. Pb induced the uptake of calcium, magnesium, and zinc in leaves.
Polizești-19, a New Rice Variety Created in the Pedoclimatic Conditions in Southeastern Romania
Authors: Ivan Ionel , Bularda Marcel , Ivan Elena , Ungureanu Nicoleta
Published: May 2023

Rice is an extremely important crop in the balance of agri-food products used by mankind. This crop feeds over 66% of the world's population and responds favorably to zonal cultivation conditions around the world. In Romania, rice is a perspective crop in the context of diversifying the agricultural production and of the need to find solutions to reduce import of agricultural products and to increase the country’s food security. There are few crops such as rice, which can provide in optimal production conditions over 8-10 tons of good quality agricultural food product, usable in human food after relatively simple processing, or which allow to obtain a wide range of food products by industrialization. The creation of new varieties and hybrids through breeding activities is important for the fact that, in the economy of a crop, a new variety contributes to the increase of productivity by 5-10% compared to the varieties in the crop. In addition, the acclimatization is better and the behavior of new varieties against stressors is improved. Hence, plant breeding, including in rice crops, is the main method of progress and efficiency of agriculture and it must be further developed in Romania. This paper presents the new Polizești-19 rice variety, obtained at Brăila Agricultural Research-Development Station, located at the northern limit of rice cultivation in Romania.
DETERMINATION OF MIKROTIK ROUTER BASED ON PRICE AND QUALITY USING SIMPLE ADDITIVE WEIGHTING (SAW) METHOD
Authors: Welda Welda
Published: May 2023

The increasing use of the internet must be balanced with the reliability of the supporting hardware, MikroTik routers are popular in Indonesia because of their affordable price and reliable performance. To facilitate institutions in determining the appropriate MikroTik router based on their needs, this research aims to determine the best MikroTik router based on price and quality factors using the Simple Additive Weighting (SAW) method. Choosing the right router can affect network performance and initial investment costs. SAW was chosen as the research method because it can provide objective results and reduce the weaknesses of subjective selection methods. The research was conducted by collecting price and technical specifications data from several types of MikroTik routers available in the market. Then, the data was analyzed using SAW to determine the best score based on price and quality factors. The results show that the MikroTik hEX RB750Gr3 has the highest score with a score of 0.704. This result can be used as a recommendation for choosing the appropriate MikroTik router for a network with consideration for price and quality.
EXPERT SYSTEM APPLICATION FOR DIAGNOSIS OF DENTAL DISEASES BASED ON WEBSITE USING BAYESIAN THEOREM METHOD
Authors: Saputra Bima Arif , Sutomo Budi , Saputri Tri Aristi
Published: May 2023

Teeth are small parts located in the upper or lower jaw. Each tooth is embedded in the gums, with its roots penetrating the gum line and entering the jawbone. The total number of teeth in the upper and lower jaw is 32. Teeth are divided into five types, each with a different function. Maintaining dental health is very important, as there are various dental diseases caused by leftover food consumed. Therefore, researchers have developed a system for diagnosing dental diseases by collecting symptoms that have been gathered through interviews with experts and patients, as well as collecting journals related to teeth. Then, all the data is entered into the application to determine the probability of the patient having a certain type of dental disease using the Bayes Theorem method.
The Role of The Covid-19 Pandemic in Moderating The Effect of Liquidity and Profitability on Dividend Policy in Manufacturing Companies Listed on The IDX
Authors: Gunafi Aang
Published: May 2023

The objective of this study is to determine how The Role of The Covid-19 Pandemic In Moderating The Effect of Liquidity and Profitability on Dividend Policy In Manufacturing Companies Listed on The IDX. The population of this study consists of all manufacturing companies listed for the years 2018 through 2021 on the Indonesia Stock Exchange. A non-probability sampling technique mixed with a purposeful sampling methodology. The data analysis method utilized in this study is panel data regression analysis, which is performed using the Eviews 10 application. The study's findings demonstrate that profitability influences manufacturing businesses listed on the IDX in the positive for the years 2018 to 2021 in terms of dividend policy. From 2018 to 2021, liquidity will not have an impact on the dividend policy of industrial businesses listed on the IDX.
Design and Application of Virtual Reality Simulation for Rehabilitation Nursing of Patients With Cervical Spondylosis Under the Background of New Medical Science
Authors: Dou Chunxia , Ji Yujie , Zhou Xinyi , Wang Yanfeng , Yang Qiaohong
Published: May 2023

Objectives: Our objective was to develop and implement a system to solve the problems that students have as a result of few opportunities for consultation and hands-on exercise in nursing practice teaching, including an inability to participate in the whole process of patients'
treatment and nursing, and lack of humanistic care for patients. Methods: The application of the system was conducted among undergraduate nursing students. In 2020, we cooperated with companies and jointly developed a virtual reality (VR) simulation of rehabilitation nursing for patients
with cervical spondylosis (CS) and applied it to undergraduate nursing students. Results:The cumulative online training time of 79 students was (30.52±16.28) minutes/person and the average number of learning times was (3.12±1.78) times/person. Overall, 97.5% of the students
rated the system as excellent. Conclusions: In thi s paper, we introduce the design, system construction, teaching design, and preliminary application effects of the system. In addition, we discuss the advantages, characteristics, limitations and countermeasures of the system, to provide
reference for the construction of VR simulation experimental teaching courses for undergraduate nursing students under the background of new medical science.
Analysis of Influencing Factors and Demand Forecast of Single Disease Demand in Chinese Public Hospitals
Authors: Zhai Xi , Zhang Shi-Qiao
Published: May 2023

Objectives: In this study, we examine influencing factors and demand forecast of single disease demand in Chinese public hospitals. Methods: We conducted a preliminary screening of the literature, according to a literature search strategy and inclusion and exclusion criteria.
Related Chinese and English articles between 2000 and 2022 were searched in the Chinese National Knowledge Infrastructure, Wanfang, PubMed, and Elsevier databases and Google Scholar. The Jadad literature scoring mechanism was used, and Stata/SE version 12.0 software was used to perform a meta-analysis
of the effect size of literature statistics. The outcome index was the 2-week visit rate. Results: We included 13 articles for meta-analysis. Their combined effect size and 95% confidence interval for chronic disease, age, gender, economic factors, medical insurance form and education
level were 3.43 (2.26, 5.51), 2.53 (1.74, 3.68), 1.3 (1.16, 1.46), 2.31 (1.16, 4.61), 3.2 (2.98, 3.45) and 1.35 (1.14, 1.6), respectively. Results revealed that for patients with chronic diseases, those>60 years of age and families with better economic conditions and higher levels of education
correlated with a higher demand for medical services among families with medical insurance for urban residents. Conclusion: Using meta-analysis, we analyzed the factors that affect the demand for medical services in China. From demographic and economic factors, national medical insurance
policies and residents' health status, we analyzed the relationship between patients with a single disease and other factors. With respect to the influence of medical service demand, relevant departments should take effective measures to increase medical service demand according to the influencing
factor of the 2-week visit rate and simultaneously provide scientific theoretical guidance for medical reform.
Investigation and Analysis of Mental State and Coping Style of Psychiatric Nurses in Public Health Emergencies
Authors: Li Hui , Mu Xishu , Wang Honghui , Gong Yanhui
Published: May 2023

Objectives: In this study, we evaluated the evaluate the psychological loads of psychiatric nurses and analyzed the influencing factors of these loads in nurse-patient communication.Methods: We used a convenience sampling method to select 400 psychiatric nurses from 5
tertiary psychiatric hospitals in Hebei, Jiangsu and Guangdong between April 5, 2020 and March 5, 2022 to participate. All participants were interviewed using a self-developed psychiatric nurse-patient communication event questionnaire and a 12-item general health questionnaire (GHQ-12). Results:
The nurses' mean GHQ-12 score for psychiatric nurse-patient communication was 5.12±3.89 points, and generally, the psychological load was at a moderately high level. Among them, 196 (49.00%) had a high psychological load. The top 5 types of violence from patients or families towards
the psychiatric nurses in the past month were injuries, verbal abuse, difficulties, work obstruction, and threatening intimidation. The most frequent factors in nurse-patient communication stress events were being worried about errors and accidents at work, being worried about not facing patient's
emotional problems properly, and concern that they lacked communication skills about specific psychiatric symptoms. A multiple linear regression analysis showed that the important predictors of a high psychological load in psychiatric nurses included being male, having greater education, having
worked a high number of years, having a high nurse characteristic factor load score, having a high environmental and social support factor load score, and experiencing workplace violence. Conclusion: The psychological load of psychiatric nurses is generally at a moderately high level
and is directly related to gender, the number of working years, whether nurses have received professional systematic training, the frequency of workplace violence factors, nurses' characteristics, and environmental and social support scores. Accordingly, we should take note of these areas
and improve them.
Manufacturing USA Semiconductor Institute(s) summary of responses to request for information
Authors: Mani Mahesh
Published: May 2023

This document provides an overview of the stakeholder responses, consensus and an overarching summary of some of the thematic areas that emerged from the Request for Information (RFI). NIST's approach to summarizing the comments received in the RFI was to capture the range and breadth of public input, including common themes and points of divergence. NIST appreciates the richness of the input received from and recognizes that detailed specific comments may not be included in this summary. Readers who would like to see the comments in their entirety can find those at regulations.gov. The RFI analysis and high-level summary was performed by the NIST team by categorizing responses by the five RFI topic areas, individual questions and corresponding responses when applicable, and respondent and organization type. Where applicable, the NIST team also appropriately mapped comments from the text of the general responses to specific RFI questions. Where applicable, specific suggestions from the responses were reproduced as part of the high-level summary.
Collective Curation across Difference: Performing Live with Race, Gender, and Sexuality
Authors: Ruiz Sandra
Published: May 2023

This piece charts the creation of a gallery within an ethnic studies unit, a syllabus in conjunction with said space, and a student-artist group exhibition titled Objects Who Hold/Objects Who Let Go. The exhibition asks one to consider how we learn to withhold and let go of the memories that bridge gaps between permanence and ephemerality. Curated in community by the artists themselves, the show drives the audience to embrace this tension of holding on and letting go as one intentionally engages with experimental art that pushes the boundaries of race, gender, and sexuality across expressions of loss and mourning.
Pedagogies of Praxis: Exercises in Embodying Social Justice for Performance Studies Seminars
Authors: Erincin Serap
Published: May 2023

This article discusses my pedagogies of praxis in the performance studies classroom focused on identity, inclusion, and social justice. I especially consider methodologies I employ in seminars focused on analyzing and making social justice performances such as Performing Human Rights and Performing Activism. This discussion explores the significance of embodied ways of learning and the materialities of the performance studies classroom. I argue that such praxis—which combines foundational and cutting-edge theories in the field, analysis of sites of performance that exemplify such work, and affective exercises that allow students to embody these theories through their lived experience—creates the most meaningful learning outcomes. I discuss various exercises I developed which offer up a material trace of the embodied, praxis-oriented pedagogy that I centre in my seminars focused on analyzing and making social justice performances.
Using an Intervention Mapping Approach to Improve Adherence to Disease-Modifying Treatment in Multiple Sclerosis
Authors: Neter Efrat , Miller Ariel
Published: May 2023

BACKGROUND

Up to 50% of individuals with multiple sclerosis (MS) who are prescribed disease-modifying treatments (DMTs) do not take them as advised. Although many studies report on DMT adherence rate, few studies report on interventions involving individuals with MS. The current paper describes the development of an intervention aimed at improving adherence to DMTs among identified nonadherent individuals with MS.

METHODS

An intervention was developed using an Intervention Mapping approach, recommendations from reviews on medication adherence, and input from individuals with MS. Its content was determined by theories of health behavior (specifically, a perceptions and practicalities approach), empirical evidence collected among the specific target population (an observational “needs assessment” stage [n = 186]), and other studies.

RESULTS

A personalized intervention was tailored to the reasons for nonadherence, uncovered during the observational needs assessment stage, to be delivered sequentially by a neurologist and a psychologist. After the intervention objectives were identified, components of the intervention were set: psychoeducation and ways of coping with adverse effects; modification of unhelpful treatment beliefs (such modifications were found predictive of adherence in the observational phase of the study); improving confidence and self-efficacy; and developing strategies for remembering to take DMTs. These components were embedded within motivational interviewing.

CONCLUSIONS

Intervention Mapping was useful in developing an intervention grounded both in the theoretical approach of perceptions and practicalities and in empirical evidence from the literature and the target sample; concurrently, identifying determinants that the intervention did not address. The effectiveness of the intervention—which could potentially improve adherence among individuals with MS—needs to be examined.
Equivalence analysis of Fourier ghost imaging and sinusoidal ghost imaging
Authors: Chen Xing-Yu , Zhou Xin , Bai Xing , Yu Zhan , Wang Yu-Jie , Li Xin-Jia , Liu Yang , Sun Ming-Ze ,   College of Electronic and Information, Sichuan University, Chengdu 610065, China
Published: May 2023

Ghost imaging, also known as correlation imaging, is one of the research hotspots in the imaging field. Various ghost imaging systems with different basic principles and implementation architectures have emerged, but the correlation between them is weak, showing a diversified trend and recent research progress is slower than before. Studying the essence of ghost imaging theory is a feasible direction to explore the unknown field of ghost imaging. Through research, we find that Fourier ghost imaging and sinusoidal ghost imaging are based on the same type of orthogonal sine speckle and cosine speckle, which have a very high similarity. At the same time, sinusoidal ghost imaging method can give a complete spatial description and spatial imaging process, so we guess that these two imaging methods can reveal the relationship between spatial imaging and Fourier domain imaging. On this basis, it is proved that Fourier ghost imaging and sinusoidal ghost imaging are equivalent in principle. The former can be realized by n-step phase shift, while the latter can be equivalent to two-step phase shift. Considering that both of these methods use sine and cosine fringes as structural speckles. By combining the spatial decomposition characteristics of sine speckle imaging, the relationship between structural speckle imaging and traditional ghost imaging is analyzed, and the principles of some methods constructed on the basis of these two methods are explained. The simulation results applied to edge detection show that the combination of the two methods can simultaneously obtain the better anti-noise performance of Fourier ghost imaging and the higher imaging efficiency of sinusoidal ghost imaging. Since sinusoidal ghost imaging relates the characteristics of image spatial decomposition to traditional ghost imaging, and their expression is equivalent to the expression of orthogonal Fourier transform domain of Fourier ghost imaging, the association of ghost imaging methods in Fourier domain and even in the whole orthogonal transform domain and spatial domain can be generalized. This conclusion may provide a way for associating different kinds of ghost imaging, and it can be hoped that more and more new types of ghost imaging systems will be developed.
1.3-μm 2.8-ns electro-optical cavity damping Nd:YVO4 laser
Authors: Yao Ming-Jie , Ge Wen-Qi , Yan Bo-Xia , Zhang Hong-Bo ,   Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100094, China,   Institute of Microelectronics, Chinese Academy of Sciences, Beijing 100094, China,   School of Optoelectronics, University of Chinese Academy of Sciences, Beijing 100049, China
Published: May 2023

1.3-μm Nd laser has significant practical applications in various fields, such as fiber communication, medical treatment, frequency conversion, and scientific research. Many applications of a 1.3-μm laser, particularly frequency conversion, benefit greatly from a short pulse width with high peak power. In the paper, an electro-optical cavity dumping Nd:YVO4 laser at 1342 nm wavelength is studied theoretically and experimentally.

The pulse width for an electro-optical cavity dumping laser is determined by the optical length of the cavity. A narrower pulse width is obtained by reducing the length of the cavity and the round trip time of the laser in the cavity. However, when the round trip time in the cavity approaches to the falling edge time of the electro-optical switch, shortening the length of the cavity will not obtain a narrower pulse width, and the falling edge time of the electro-optical switch will influence the laser pulse width. The temporal characteristics of the laser pulse are simulated when the falling edge time of the electro-optical switch is close to the round trip time in the cavity.

The influence of the falling edge time of the electro-optical switch on the laser pulse duration is analyzed theoretically. The modified rate equation is used to study the relationship between the falling edge time and the laser pulse width.

We demonstrate an electro-optical cavity dumping Nd:YVO4 laser. The atom percent of 0.3% Nd:YVO4 placed in a short Plano-concave cavity is in-band pumped by an 880 nm quasi-continuous-wave diode. A fiber-coupled diode laser module (NA = 0.22) with a power of 30 W is used. An LiNbO3 electro-optical switch is employed for the cavity-dumping. The 1342-nm cavity-dumping laser operates at a repetition rate of 1 kHz, single-pulse energy of 0.21 mJ, and pulse width of 2.8 ns. Near-diffraction-limited beam quality with an \begin{document}$ M^2 $\end{document}value of < l.2 is achieved. The setup uses MgO:PPLN crystal to generate efficient second harmonic at 671 nm, with a pulse width of 1.8 ns. To the best of our knowledge, this is the shortest pulse duration ever obtained from 1.3 μm actively Q-switched Nd-doped laser.
A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies ANXA1 as a susceptibility locus for persistent wheezing
Authors: Granell Raquel , Curtin John A , Haider Sadia , Kitaba Negusse Tadesse , Mathie Sara A , Gregory Lisa G , Yates Laura L , Tutino Mauro , Hankinson Jenny , Perretti Mauro , Vonk Judith M , Arshad Hasan S , Cullinan Paul , Fontanella Sara , Roberts Graham C , Koppelman Gerard H , Simpson Angela , Turner Steve W , Murray Clare S , Lloyd Clare M , Holloway John W , Custovic Adnan ,   on behalf of UNICORN and Breathing Together investigators
Published: May 2023

Background:

Many genes associated with asthma explain only a fraction of its heritability. Most genome-wide association studies (GWASs) used a broad definition of ‘doctor-diagnosed asthma’, thereby diluting genetic signals by not considering asthma heterogeneity. The objective of our study was to identify genetic associates of childhood wheezing phenotypes.

Methods:

We conducted a novel multivariate GWAS meta-analysis of wheezing phenotypes jointly derived using unbiased analysis of data collected from birth to 18 years in 9568 individuals from five UK birth cohorts.

Results:

Forty-four independent SNPs were associated with early-onset persistent, 25 with pre-school remitting, 33 with mid-childhood remitting, and 32 with late-onset wheeze. We identified a novel locus on chr9q21.13 (close to annexin 1 [ANXA1], p<6.7 × 10-9), associated exclusively with early-onset persistent wheeze. We identified rs75260654 as the most likely causative single nucleotide polymorphism (SNP) using Promoter Capture Hi-C loops, and then showed that the risk allele (T) confers a reduction in ANXA1 expression. Finally, in a murine model of house dust mite (HDM)-induced allergic airway disease, we demonstrated that anxa1 protein expression increased and anxa1 mRNA was significantly induced in lung tissue following HDM exposure. Using anxa1-/- deficient mice, we showed that loss of anxa1 results in heightened airway hyperreactivity and Th2 inflammation upon allergen challenge.

Conclusions:

Targeting this pathway in persistent disease may represent an exciting therapeutic prospect.

Funding:

UK Medical Research Council Programme Grant MR/S025340/1 and the Wellcome Trust Strategic Award (108818/15/Z) provided most of the funding for this study.
The structural basis of the multi-step allosteric activation of Aurora B kinase
Authors: Segura-Peña Dario , Hovet Oda , Gogoi Hemanga , Dawicki-McKenna Jennine , Hansen Wøien Stine Malene , Carrer Manuel , Black Ben E , Cascella Michele , Sekulic Nikolina
Published: May 2023

Aurora B, together with IN-box, the C-terminal part of INCENP, forms an enzymatic complex that ensures faithful cell division. The [Aurora B/IN-box] complex is activated by autophosphorylation in the Aurora B activation loop and in IN-box, but it is not clear how these phosphorylations activate the enzyme. We used a combination of experimental and computational studies to investigate the effects of phosphorylation on the molecular dynamics and structure of [Aurora B/IN-box]. In addition, we generated partially phosphorylated intermediates to analyze the contribution of each phosphorylation independently. We found that the dynamics of Aurora and IN-box are interconnected, and IN-box plays both positive and negative regulatory roles depending on the phosphorylation status of the enzyme complex. Phosphorylation in the activation loop of Aurora B occurs intramolecularly and prepares the enzyme complex for activation, but two phosphorylated sites are synergistically responsible for full enzyme activity.
Exploring the dynamics of vascular adaptation
Authors: Shimizu Thomas S , Kiers E Toby , Stone Howard A
Published: May 2023

A combination of in toto imaging and theory suggests a new mechanism for the remodeling of veins in vascular networks.
Review of Episodic Voyage of Engineering Surveying and Cartography in India
Authors: Nanda Rabindranath , Mishra Siba Prasad , Barik Kamal Kumar , Sethi Kumar Ch.
Published: May 2023

This study presents the Episodic Voyage of Engineering Surveying and Cartography in India to know our past development in mapmaking and cartography, which is as old as Ptolemy’s expedition in the 2nd century AD in India. Starting from ropes and sticks to measure, plumb bobs to position, site rule for sighting, and clinometer for height measurement, the Indians and people from other countries, developed the present instruments and methodologies. They have evolved by gathering big data and up to making smart maps by today. The methodology employed is to collect data about the development of innovative technologies in the last 15th to 21st centuries.  The journey commenced from Zareb, Kadi, etc. to the development of geo-informatics with the practices of Aerial photography, Geographical Information Systems (GIS), Remote Sensing (RS), Global Positioning Systems (GPS), Image Processing, Photogrammetry by unmanned aerial vehicle (UAV), Light Detecting and Ranging (LiDAR), Web GIS, through large-scale map generation. The innovative practices have given a new direction to the subjects like geography, geology, urban planning, landscaping, and other human application services.  The present study includes the search for the advances in surveying and map-making journey to date and the way forward. Eventually, the evolution of technologies will influence greatly the surveying and map-generating Present process. The application handling in the current geospatial ecosystem can be complied with by compiling large-scale maps 1:500, 1:1000, etc. through automation for better smart city planning in India. The change shall paddle the economic growth in different developing countries. However, the survey of marine territories of India is poorly researched.
Satisfaction and Knowledge of Emergency Residents about Journal Club
Authors: Alotaibi Majed Alawe , Alanazi Mazi Mohammed , Alanazi Fadiyah Dhami , Homoddah Ahmad Mohammad , Alsaedi Hashim Marshud R. , Alharbi Fahad Hadram Al Asemr , Alamri Rayan Dhaif Allah A.
Published: May 2023

Background: The key teaching-learning activity journal club provides a platform for developing critical evaluation skills. It makes it easier to stay current with new research, enabling residents to improve patient care, and assisting them in developing into knowledgeable specialists.

Methods: A cross-sectional survey was conducted in March 2023 among emergency department residents at King Saud Medical City (KSMC), King Salman Hospital, Aliman General Hospital, and Imam Abdulrahman Alfaisal Hospital. This study was conducted to find out how individuals felt about having journal club as part of the curriculum. 124 emergency registrars participated in a survey. The goal of the study was explained, and instructions for filling out the survey forms were given. In order to analyze the data, SPSS version 24 was used. The study variables were represented by descriptive statistics (the frequency with percentages for categorical variables), and the chi-square test was employed to determine statistical significance.

Results: A total of 124 (N = 124) emergency residents responded to the survey. 45 (36.2%) residents from R1 and 33 (26.6%) from R2. 71% of participants were male and 29% were female. Journal clubs are not well known to the majority of R1 locals (48.7%). However, a significant portion of R4 residents (29.27%) are familiar with journal clubs. The majority of residents (39%), first learned about journal club from friends, followed by the internet (35%), journal club attendance (9%), and literature (16% of residents), in that order. The main justification offered for not incorporating a journal club into the curriculum is that it takes a lot of time to prepare.

Conclusion: A journal club would increase residents’ capacity for lifelong learning. It is a useful educational tool to help them comprehend the processes involved in conducting research that would enhance patient care.
Retinal Damage After Repeated Low-level Red-Light Laser Exposure
Authors: Liu Huanyu , Yang Yuan , Guo Jingli , Peng Jie , Zhao Peiquan
Published: May 2023

This case report discusses retinal damage incurred after repeated low-level red-light laser exposure in a 12-year-old female patient with a history of myopia.
Kielin/chordin‐like protein enhances induction of osteoblast differentiation by Bone Morphogenetic Protein‐2
Authors: Nagasaki Kei , Yamada Atsushi , Sasa Kiyohito , Kamijo Ryutaro
Published: May 2023

Bone morphogenetic proteins (BMPs) play a key role in embryonic differentiation for osteoblast and bone formation. Kielin/chordin‐like protein (Kcp) is known to enhance the effects of BMP signaling. Here, we present ALP activity, gene expression, and calcification data demonstrating that Kcp affects the differentiation of C2C12 myoblasts into osteoblasts. We report that the presence of Kcp enhances the ability of BMP‐2 to induce the differentiation of C2C12 myoblasts into osteoblasts. Additionally, BMP‐2‐mediated stimulation of phosphorylated Smad1/5 was apparently enhanced in the presence of Kcp. The present findings may contribute to progression toward the clinical use of BMPs for treatment of bone fracture, osteoarthritis, and other similar conditions.
Functional Regression Control Charts with an Application to Ship Fuel Consumption Monitoring
Authors: Capezza Christian , Centofanti Fabio , Lepore Antonio , Menafoglio Alessandra , Palumbo Biagio , Vantini Simone
Published: May 2023

In many industrial scenarios, the process quality characteristic of interest can be either a scalar or, in a more general case, a profile, that is, a function defined on a compact set, usually time or space. In the latter case, the quality characteristic can also be referred to asfunctionalquality characteristic. Profiles are usually obtained from measurements of the quality characteristic collected at discrete time or space points. The set of statistical process control techniques developed for this type of data is calledprofile monitoring. Often, thanks to the new data acquisition technologies, together with the quality characteristic of interest, other covariates associated with it are available as well. For example, this applies to the maritime transportation, where shipping companies are urged by worldwide and European regulations to monitor CO2emissions of their fleet, when many other additional factors, which affect CO2emissions, are also jointly measured. Motivated by this context, this article illustrates the use of the functional regression control chart framework to enhance the monitoring of either a scalar or a functional quality characteristic using the information on covariates related to it, which can be in the form of scalars or profiles as well.
Fourier Expansion
Authors: Parkinson Christian
Published: May 2023

We provide a basic overview of Fourier expansion: a method for representing a function as an infinite sum of sine waves with different amplitudes and frequencies. We develop the Fourier expansion of a function using either real or complex Fourier modes and discuss some issues of convergence and approximation by truncated Fourier series. We briefly mention the theoretical connection with the continuous Fourier transform and discuss generalizations to other types of orthogonal function expansion. Lastly, we point out some applications of Fourier expansion in statistics and other disciplines.
Process Analysis with Data Segments
Authors: Kenett Ron S.
Published: May 2023

Control charts are applied in running a process under statistical control. Process capability analysis is conducted retrospectively on data to characterize a process under control and set up the control limits of a control chart. In this article, we expand on the process capability analysis by considering time‐related patterns. Specifically, we focus on data segments that can show up in the data collected during process capability analysis. If such segments are detected, and investigations reveal the causes for such segments, the analyst might decide to focus on a data segment representing a steady‐state stable process, as opposed to the full data collected for process capability analysis. In this context, one will aim at identifying transient periods and not include them in the computation of control limits. We provide here two methods for identifying such segments. One method is based on decision trees. The second method is applying functional data analysis.
2022 American College of Rheumatology Guideline for Exercise, Rehabilitation, Diet, and Additional Integrative Interventions for Rheumatoid Arthritis
Authors: England Bryant R. , Smith Benjamin J. , Baker Nancy A. , Barton Jennifer L. , Oatis Carol A. , Guyatt Gordon , Anandarajah Allen , Carandang Kristine , Chan Karmela Kim , Constien Deb , Davidson Eileen , Dodge Carole V. , Bemis‐Dougherty Anita , Everett Sotiria , Fisher Nadine , Fraenkel Liana , Goodman Susan M. , Lewis Janet , Menzies Victoria , Moreland Larry W. , Navarro‐Millan Iris , Patterson Sarah , Phillips Lawrence “Rick” , Shah Neha , Singh Namrata , White Daniel , AlHeresh Rawan , Barbour Kamil E. , Bye Thomas , Guglielmo Dana , Haberman Rebecca , Johnson Tate , Kleiner Anatole , Lane Chris Y. , Li Linda C. , Master Hiral , Pinto Daniel , Poole Janet L. , Steinbarger Kimberly , Sztubinski Daniel , Thoma Louise , Tsaltskan Vlad , Turgunbaev Marat , Wells Courtney , Turner Amy S. , Treadwell Jonathan R.
Published: May 2023

Objective

To develop initial American College of Rheumatology (ACR) guidelines on the use of exercise, rehabilitation, diet, and additional interventions in conjunction with disease‐modifying antirheumatic drugs (DMARDs) as part of an integrative management approach for people with rheumatoid arthritis (RA).

Methods

An interprofessional guideline development group constructed clinically relevant Population, Intervention, Comparator, and Outcome (PICO) questions. A literature review team then completed a systematic literature review and applied the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to rate the certainty of evidence. An interprofessional Voting Panel (n = 20 participants) that included 3 individuals with RA achieved consensus on the direction (for or against) and strength (strong or conditional) of recommendations.

Results

The Voting Panel achieved consensus on 28 recommendations for the use of integrative interventions in conjunction with DMARDs for the management of RA. Consistent engagement in exercise received a strong recommendation. Of 27 conditional recommendations, 4 pertained to exercise, 13 to rehabilitation, 3 to diet, and 7 to additional integrative interventions. These recommendations are specific to RA management, recognizing that other medical indications and general health benefits may exist for many of these interventions.

Conclusion

This guideline provides initial ACR recommendations on integrative interventions for the management of RA to accompany DMARD treatments. The broad range of interventions included in these recommendations illustrates the importance of an interprofessional, team‐based approach to RA management. The conditional nature of most recommendations requires clinicians to engage persons with RA in shared decision‐making when applying these recommendations.
Intrinsically Flexible and Aging Resistant Fluorene‐Based Rod‐Coil Copolymer for Bendable Deep‐Blue PLEDs
Authors: Li Hao , Yu Mengna , Gu Jiabin , Bao Qiujing , Wang Yangcheng , Li Yang , Ma Yan , Bai Lubing , Zhuo Zhiqiang , Zhang Yunlong , Zhang Jingrui , Wang Yeyang , Luo Manman , Liu Yiren , Li Chenghui , Lin Jinyi , Zhang Xinwen , Feng Quanyou , Xie Linghai
Published: May 2023

In the field of flexible light‐emitting display, goal‐oriented intelligent molecular design is used to control various behaviors of molecules, which provides potential for the development of flexible light‐emitting conjugated polymers (LCPs). The introduction of non‐conjugated units into polymer molecules is a key prerequisite for realizing the intrinsic flexibility, but its easy interchain slip will also lead to the formation of interchain excited states, which is detrimental to the efficiency of light‐emitting diodes. Herein, two kinds of fluorene‐based rod‐coil copolymer with stable deep blue emission characteristics is presented and with Commission Internationale de L'Eclairage (CIE) coordinates of (0.18, 0.14) and (0.15, 0.09), respectively. Surprisingly, the copolymer films show efficient blue emission even at 100% tension. Meanwhile, the rod‐coil copolymer possesses better aging resistance compared to rigid π‐conjugated counterparts. Finally, both rigid and flexible light‐emitting diodes based on rod‐coil copolymer exhibit stable deep blue emission, and the G2‐based PLED with CIE coordinates of (0.16, 0.08), which approach National Television System Committee standard blue specification. These results confirm the validity of rod‐coil copolymer design strategy in constructing inherently flexible polymers with deep blue emission, which have great application potential in flexible PLEDs.
Toward High Bias‐Stress Stability P‐Type GaSb Nanowire Field‐Effect‐Transistor for Gate‐Controlled Near‐Infrared Photodetection and Photocommunication
Authors: Sa Zixu , Liu Fengjing , Zhuang Xinming , Yin Yanxue , Lv Zengtao , Wang Mingxu , Zhang Jie , Song Kepeng , Chen Feng , Yang Zai‐xing
Published: May 2023

The bias‐stress instability of nanowires (NWs) field‐effect‐transistors (FETs), originated from the surface trappings, are challenging greatly the functionalization of III‐V group semiconductors in next‐generation electronics and optoelectronics. In this study, the solution‐processed high‐κ oxide dielectric shell is configured uniformly onto the surface of GaSb NWs, contributing to the excellent bias‐stress stability of as‐constructed p‐type NWFETs. Owing to the interdiffusion between Al and Ga, the oxide dielectric shell is Ga‐AlOx. With an optimal oxide dielectric shell, the as‐constructed p‐type GaSb NWFETs show an insignificant attenuation of on‐state current (within 10%) and a negligible negative shift of threshold voltage under 60 min continuous gate bias, which is far better than that of pristine GaSb NWFETs, resulting from the electric double layer effect. Benefiting from the excellent bias‐stress stability, when configured into the near‐infrared photodetector, NWFET exhibits desirable stability and gate‐controlled photodetection behaviors. Idark and Ilight are effectively modulated by gate voltage, resulting in gate‐controlled responsivity and gain under the illumination of 1550 nm laser. In the end, the as‐constructed bias‐stress stability NWFET demonstrates expected gate‐controlled photodetection imaging and photocommunication ability. The strategy of solution‐processed oxide dielectric shell promises high bias‐stress stability NWFETs for gate‐controlled photodetection and photocommunication.
Synthesis of 4‐Furan‐ and 4‐Pyrrol‐3‐yl‐2H‐chromenes from Naturally‐occurring Compounds by Gold(I)‐Catalyed Domino Reactions
Authors: Solas Marta , Renedo Lorena , Suárez‐Pantiga Samuel , Sanz Roberto
Published: May 2023

A gold‐catalyzed cascade double cyclization reaction has been designed to synthesize heterobiaryl compounds such as furanyl and pyrrolyl 2H‐chromenes from bis(alkynyl)‐1,2‐diols and 1,2‐amino alcohols. The starting materials are readily available from biomass platform molecules such as α‐hydroxy acids and α‐amino acids. The process involves an initial heterocyclodehydration step enabling the formation of the furan or pyrrole ring, followed by an alkyne hydroarylation to form the chromene core.