bluuebunny/crossref_metadata_2025 huggingface dataset:
MAIN FACTORS OF INFLUENCE ON GEOECOSYSTEMS OF WATER BASINS AND RISKS OF THEIR DESTRUCTION
Authors: Iemelianov V.O. , Kiriakov P.O. , Rybak O.M. , Paryshev O.O. , Stupina L.V.
Published: January 2025

Geo-ecological situation in Ukraine can be considered a crisis without exaggeration. The emergence of a number of geo-ecological problems is caused by long-term structural deformations of the economy and the development of the most environmentally dangerous industries of the economy and the development of the most environmentally dangerous industries. The main Ukraine's main problems are directly related to the disruption of important geoecological functions of the components of the natural environment − lithosphere, atmospheric air, water and soil environment, flora and fauna.
Due to Russia's large-scale armed aggression has added a powerful negative impact on the environment due to the terrible consequences of military actions, primarily related to damage to communications, destruction of enterprises and other hazardous facilities, contamination of water and land resources in conditions of impossibility to exercise effective control and prompt elimination of the negative impact of military operations.
The article for the first time touches upon the issues related to geo-ecological problems of open water basins of Ukraine, aquatic subsystems of water resources and water resources of the country. Ukraine, aquatic subsystems of water basins, as well as the geo-ecological state of groundwater. waters. The impact of submarine discharge of groundwater on the geo-ecosystems of open water basins and aquatic subsystems, determined the risks of destruction of their resources in modern conditions.
The conceptual bases of the strategy of geo-ecological studies of water basins, the necessity of development of legal base of activity in this direction is noted.
PRELIMINARY RESULTS OF GEO-ARCHAEOLOGICAL RESEARCH OBTAINED DURING THE 3rd INTERNATIONAL EXPEDITION OF THE R/V “MARE NIGRUM” (01.06.2024 – 15.06.2024)
Authors: Ievlev M.M. , Chubenko O.V. , Fedoronchuk N.O. , Iemelianov V.O.
Published: January 2025

The research cruise was carried out within the framework of the Horizon 2020 project “Development of Optimal and Open Research Support for the Black Sea” (DOORS). The DOORS-3 program was developed as part of Work Package 4. The project started on June 1, 2021 and will end on May 31, 2025, and will last 48 months. The beneficiary countries of the project are Romania, Bulgaria, Turkey, Georgia, Germany, the United Kingdom, Ukraine, Moldova, Italy, France, the Netherlands, Spain, Ireland, Spain, and Greece. The overall goal of the project is to contribute to the improvement of the Black Sea environment. The DOORS project aims to address the overall need to support the restoration of environmental quality and sustainability of the Black Sea. DOORS will raise public awareness and promote the rational use of the Black Sea environment, contribute to closer coordination between the next cycle of implementation of the MSFD (EU Marine Strategy Framework Directive) and the Bucharest Convention, and deepen public understanding of the value of ecosystem services in the Black Sea. Studying the changes in the Black Sea level is also important for developing forecasts of the development of its coastal zone as a result of global climate warming. For this purpose, data on changes in landscape and geomorphological conditions in the coastal zone, obtained on the basis of historical and paleogeographic studies conducted in the coastal areas of the Black Sea, can be used.
MARTIN HEIDEGGER’S METAPHYSICAL QUESTION 1935-1937: GENESIS AND CONSEQUENCES. PART ONE
Authors: MARINCHUK Yurii
Published: January 2025

The article deals with the subject of poetic language, its qualities, conditions and purpose. It is the language of creativity and sets out the metaphysics in art. The metaphysics considered is the intersection of being and time in thing and thing as a special place where thoughts appear in the artistic act. The first plan of the stated metaphysics is considered in the fourfold geometric intersection of the essential-artistic space – the square (Gefirt) of the world, earth, mortals and immortals. The result of the semantic field of landscape from our memory of native lands is a history of the meanings of thinking, and things are pre-thought states. A thing is the way the world is given - a narrative of the structure of thinking, life and human activity. The second plan of the stated metaphysics is considered, on the one hand, from the position of poets and oracles, as those who express themselves historically, and, on the other hand, from the inner basis of thinking. This foundation is intuitive, affective-intellectual thought. It emerges in the circle of unknown, unexplored, impossible things – in the topos, where the world of life is formed by co-existence with what we enter into, creating meaning for ourselves. Co-existence means examining the thing for the interruption of being and time and what information about the world can be extracted. But it turns out that there is no being at all and no time at all, for there are no two things of one thing: that which belongs to being and that which belongs to time. It turns out that the intersection is thinking. It builds meaningful forms, lives them and carries them in language. To a certain extent, the thinking we possess is seen as a device of time. Martin Heidegger, through the existential Care, arranges thinking by the relation of being and time in a thing. He draws our attention to the fact that not only man owes his truth to the co-existence of life, but also the thing with its nature. The purpose of this article is to investigate the foundations of poetic language of creation as a way of presentation of metaphysics in art.
TRANSFORMATION OF POLITICAL DISCOURSE IN THE CONTEXT OF MEDIATIZATION: CHALLENGES FOR SOCIAL ORDER IN UKRAINE
Authors: VELICHKOVSKYI Ruslan
Published: January 2025

Research objective: To analyze the transformation of political discourse under mediatization conditions and its impact on social order in Ukrainian society. The study employs a comprehensive application of systemic approach, institutional, comparative and historical methods, as well as content analysis of official social media pages of state institutions. The dualistic nature of modern mediatization is established, which manifests through simultaneous processes of media integration into traditional social institutions and the formation of media as an independent social institution. Key challenges to social order arising from the mediatization of political discourse are identified. A conceptual model of interaction between media and political institutions in the context of social order transformation is proposed. The research reveals the emergence of new forms of political engagement and participation facilitated by digital platforms. It demonstrates how social media has become a crucial arena for political discourse, reshaping power dynamics between political actors and citizens. The study also highlights the potential risks of information manipulation and the spread of misinformation in the mediatized political environment. The understanding of mechanisms of political actors’ adaptation to media requirements and transformation of traditional forms of political communication is expanded. The research results can be used to develop communication strategies for state institutions under mediatization conditions. For the first time, a comprehensive analysis of the impact of political discourse mediatization on social order in the Ukrainian context is conducted, taking into account the specifics of hybrid threats. An in-depth study of the influence of digital technologies and social networks on the transformation of political communication in the context of hybrid threats is suggested. The article is empirical in nature.
INTERNATIONAL CHARITABLE ORGANIZATIONS: ESTABLISHMENT, DEVELOPMENT AND FEATURES OF FUNCTIONING
Authors: PIDSADNIUK Petro
Published: January 2025

The article is dedicated to the study of the peculiarities of charity development and the functioning of international charitable organizations that have acquired the status of an international entity. Such non-governmental actors are able to respond adaptively and act more quickly and locally on the world stage to address the most pressing issues, providing assistance and support to the most vulnerable categories and in the most critical geopolitical spaces. With the help of an interdisciplinary approach, it was possible to identify the historical background of the origin of the phenomenon of selfless human activity, a systematic political and legal analysis of international and domestic legislation helped to identify the peculiarities of the functioning of international charitable organizations in the United States, Europe and Ukraine, and a generalization of the obtained results crystallized the foundations and features of their direct involvement in problem areas.The difference between international non-governmental organizations and international charitable organizations was proved. The author identifies the main sources of funding for such structures through grants, donations from individuals and legal entities, international organizations and governments. It is established that the tasks of establishing and operating international charitable organizations are implemented in three areas of activity, including non-refundable assistance, administration of response and recovery projects, lobbying and actualization of the problem for the world community through influence on the political establishment and public opinion.
Memento Mori: The Birth of Post-Mortem Photography
Authors: Bussing López Ilse Marie
Published: January 2025

In this article, I will be focusing on the origins and characteristics of this type of photography, mainly as it unfolded in Britain and the United States. Three texts that I employ in order to draft the origins and transformation of post-mortem photography in Britain and the United States, from its beginnings in 1839 to our time are: Stanley Burns’s Sleeping Beauty (1990), Jay Ruby’s Secure the Shadow: Death and Photography in America (1995), and Audrey Linkman’s Photography and Death (2011).  These works coincide with one idea: photographing loved ones who have passed away, as well as the general response to this practice have evolved, as have the notions and sensibilities towards death itself. This study poses two fundamental questions, when faced with a dread for this custom: 1. why is photographing our dead so frightening and appealing at the same time?; and, 2. in a society that has become desensitized to viewing images presented by the media of mangled bodies, of grotesque products of crime or war, why is the notion of photographing a deceased, loved one so offensive?  After all, photographing our loved ones who have passed away, is as old as photography itself.
Interpretation of an “Article-by-Material Claim” in the Utility Model Act: Focusing on the Patent Court 2023(Heo)14578 Decision
Authors:   The Institute of Legal Studies, Kyunghee University, ZHAO Chunlian , JUNG Chaho
Published: January 2025

The object of protection under the Utility Model Act is the shape and structure of an article. However, if a claim claims an article and specifies a part of the article, such as a material, which is not the object of protection, how should such a claim be interpreted? Recently, the Patent Court’s 2023(Heo)14578 decision, which explained the interpretation of such an“article-by-material claim,” was handed down. In that decision, the Patent Court explained that when determining the scope of rights, “the article should be identified as having a shape, structure, etc. specified by all descriptions of the claim, including descriptions of the article’s material, and compared with the device to be confirmed.” This paper verifies the subject patent court decision, and after comparatively analyzing the relevant legal theories of China, Japan, and Taiwan area, argues that the following legal theories apply to the interpretation of an article-by-material claim. First, it should be permitted to limit all or part of the article to a certain ‘material’ in the claim for utility model registration. Second, the material so limited should be recognized as an element, and according to the all-elements rule, the registrability, scope of rights, etc. of the device should be determined by including the material as an element. Such a legal principle should be also applied to an article-by-process claim.
The impact and challenges of legal platforms on law practices : Focusing on Attorney Advertising and Legal Document Generation
Authors:   The Institute of Legal Studies, Kyunghee University, Na Ji-Won
Published: January 2025

As legal platforms become a core service delivery method of legaltech, it is necessary to examine new issues in legal ethics, including the Lawyers Act. This study aims to analyze the impact and challenges of legal platforms on the legal business, focusing on case acceptance (lawyer advertisement) and legal work (legal document Generation). First, we examined whether lawyer search services on legal platforms are permissible advertisements or prohibited paid solicitations under the Lawyer Act. Then, we analyzed whether automatic legal document Generation services using generative AI technology constitute the handling of legal services by non-lawyers(Unauthorized practice of law).
Based on these findings, we concluded that there are reasonable ways to regulate lawyer advertisements and issues to appropriately regulate automatic legal document Generation. The study concludes that attorney search services should be principally allowed as advertising, though supervision is needed regarding commission levels and recommendation algorithm fairness. Automated legal document services are currently not considered legal practice due to their lack of case specificity and legal reasoning process. However, the study suggests legislative amendments, including the Attorney-at-Law Act, or regulatory exemptions to promote legal tech development.
The issue of the impact of legal platforms on the law business should no longer be viewed as a matter of protecting the profession or aligning the interests of interest groups. It is more of an issue of the times due to the structural transformation of our society. In solving these challenges, it is important to improve people’s access to justice and to overhaul laws and systems that enable continuous innovation in legal services.
Fizikai Nobel-díj 2024
Authors: Csabai István
Published: January 2025

Az idei fizikai Nobel-díj sokakban kisebb meglepetést váltott ki, mivel az avatatlan szemlélők számára a díjazott témakör nem kapcsolódik a fizika hagyományos területeihez. Ebben a rövid cikkben igyekszem elmagyarázni, hogy miként alapozták meg a statisztikus fizikában gyökerező modellek a napjainkban rohamos ütemben fejlődő mesterségesintelligencia-algoritmusokat.
A valóság visszatér
Authors: Csaba László
Published: January 2025

A cikk a 2024. évi közgazdasági Nobel-díjasok hatalmas és releváns munkáját ismerteti igen röviden. Kiemeli, hogy abban az empirikusan ellenőrizhető megállapítások és a gazdaságpolitikai gyakorlatban közvetlenül alkalmazható felismerések dominálnak. Ez fordulatot jelent a korábbi évek gyakorlatával szemben, amikor az elvont formalizálás és a modellek esztétikája uralkodott az alkalmazás szempontjával szemben.
Hizib and Wafaq: Magical Symbols that Bring to Life the Tariqa Tradition in West Java
Authors: Yunus Badruzzaman M. , Zulaiha Eni
Published: January 2025

This study explores the use of magical symbols within the Tariqa community in West Java, which faces accusations of deviation and conflict with the Takfiri group. Understanding this issue is crucial for mediating conflicts and promoting religious moderation in Indonesia. The research employs a qualitative descriptive approach, focusing on the Idrisiyyah-Tasikmalaya, Tijaniah-Garut, and Shadziliyyah tariqas. Data is analyzed using a semiotic model, examining magical symbols, their meanings, and practitioners' spiritual experiences. Data collection involves purposive sampling through interviews and field observations. Overall, the use of magical symbols is deemed legitimate within Islamic law and does not signify deviation or impurity.
Punk Faith: How Muslim Punks Use Their Voices for Social Change and Community Engagement
Authors: Solahudin Dindin , Rojudin Rojudin
Published: January 2025

The interplay between religion and subculture presents a fascinating lens to examine social change, particularly in urban contexts. This study explores the phenomenon of Muslim Punk communities in Indonesia, a unique fusion of global subcultural identities and local Islamic values. Grounded in the discourse of globalization and transnationalism, the research highlights how subcultures transcend national boundaries, adapting to local norms and religious contexts while maintaining their core identity. Utilizing a phenomenological approach, data were collected from 24 community members (21 males and 3 females) aged 18–30 years, through in-depth interviews, observations, and field notes. The findings reveal that permissive parenting and rebellion against authoritarian familial structures are significant factors driving individuals toward the punk subculture. However, the research also uncovers a significant correlation between religious intensity and community detachment, with heightened religious adherence prompting individuals to reconsider behaviors conflicting with Islamic principles. Quantitative analysis of religious practices, such as daily prayers, fasting, and Quran recitation, coupled with qualitative insights into community dynamics—such as dress codes, substance use, and social rituals—illustrates how religiosity influences self-regulation and social conformity. The study concludes that increased religiosity reduces deviant behaviors, fostering a shift away from subcultural attachment. This phenomenon underscores the innate human inclination toward spiritual fulfillment, transcending subcultural identities and societal norms. By examining the intersection of religion and subculture, this research contributes to broader discussions on globalization, social change, and identity formation in developing countries. It provides critical insights into how global subcultures adapt to localized religious and moral frameworks, offering a valuable perspective for understanding the dynamic interplay between culture and spirituality in an increasingly interconnected world.
Girls’ Schools in Sri Lanka
Authors: Albrecht Jessica Annette
Published: January 2025

This article uses the case study of Sri Lankan women who went to Buddhist and Christian middle-class girls’ schools in Colombo and Kandy to examine the influence of affect on their intersectional lives. I use the theories of Judith Butler and Sara Ahmed on affect. Affects, they agree, emerge within the brinks of contact, it is the process of being acted upon (being affected) and acting on (affecting)—affect is a specific form of relation. This article interwaves the ethnographic findings with the theoretical discussions to progressively build on it and show precisely the relations between affect, language and intersectional identities. Buddhist and Muslim girls’ voices and experiences at middle-class girls’ schools in Sri Lanka will be examined from an intersectional perspective. I propose to think of affect as the binding glue of the frames of our intersectional identities.
Królowa Jadwiga i odpusty jubileuszowe
Authors: Baran Wojciech
Published: January 2025

Z osobą królowej Jadwigi związane są dwa papieskie przywileje odpustowe. Pierwszy – udzielony z racji celebrowanego w 1390 roku w Rzymie roku jubileuszowego – uzyskała dla swych poddanych sama królowa. Z powodu trudności związanych z pielgrzymką do Rzymu Pani Wawelska w przepięknej literacko suplice poprosiła papieża Bonifacego IX o możliwość uzyskania odpustu jubileuszowego poprzez pielgrzymkę do kościołów Krakowa w przeciągu czterech miesięcy od ogłoszenia papieskiego dokumentu. 16 października 1391 roku papież wydał bullę, w której udzielił odpustu zupełnego – można go było uzyskać przez rok od Bożego Narodzenia 1391 roku za nawiedzenie czterech głównych kościołów w Polsce, Litwie, na Rusi bądź w metropolii gnieźnieńskiej, co znacznie przekraczało hojnością suplikę polskiej królowej. Drugi odpust związany ze Świętą Jadwigą został udzielony przez Penitencjarię Apostolską na mocy władzy nadanej przez papieża Franciszka 28 maja w 2024 na prośbę arcybiskupa krakowskiego Marka Jędraszewskiego z okazji obchodów 650-lecia urodzin św. Jadwigi. Odpust ten mogli uzyskać wierni, którzy w dniach 30 maja–8 czerwca 2024 roku pobożnie uczestniczyli w uroczystościach jubileuszowych w katedrze wawelskiej i pomodlili się przy relikwiach świętej. Artykuł zawiera łacińskie edycje tekstów przywilejów odpustowych oraz ich tłumaczenie na język polski.
Mario Briceño-Iragorry; El Espíritu de la Letra
Authors: Hernández Carmona Luis Javier
Published: January 2025

Esta reflexión destaca la relación que existe entre palabra y espíritu latinoamericano expresada en la obra del escritor venezolano: Mario Briceño-Iragorry. Donde, espíritu interpreta la permanente intención por manifestar una subjetividad trascendente en procura de crear consciencia de los procesos históricos a partir de los espacios íntimos del enunciante. Además de referir la importancia que destaca la universalidad como principio dinámico en la producción de discursos reflexivos que hurguen en los cimientos de la historia y encontrar las bases elementales para construir andamiajes presentes que permitan la proyección futura de los pueblos a partir de su originalidad histórica. Para ello se utiliza el método ontosemiótico que permite interrogar los textos en función del sujeto enunciante, que a partir de la esfera patémica, produce una relación intersubjetiva entre él y los contextos analizados, para de esa forma, el espíritu de la letra se convierta en testimonio sentido dentro de la construcción del discurso cultural. Y bajo esa perspectiva de análisis, el espíritu permita establecer contextualizaciones teóricas que intercambian sustentos y referencias entre: historia, cultura y tradición; maneras de acercarse al devenir de los tiempos e interrogarlos en torno a los sujetos.
Sitio de vida: sustrato de una Educación Ambiental para la Sostenibilidad.
Authors: Valero Avendaño Maria nay
Published: January 2025

La crisis ambiental que vive actualmente el planeta propone retos a los docentes y estos desde el espacio pedagógico se apropian de la Educación Ambiental para la Sostenibilidad, lo que implica incorporar  estrategias que tributen a la comprensión de la problemática para la acción coherente y práctica desde el contexto  de convivencia de los actores. Bajo esta perspectiva la autora develó en un proceso de investigación una serie de conceptos derivados, entre ellos, el Sitio de vida, bajo los métodos y técnicas de la Teoría Fundamentada (Strauss y Corbin, 2002) y la herramienta de Atlas ti.8 para la elaboración de las redes conceptuales que le otorgan propiedades y dimensiones para aproximar estos al sustrato de una pedagogía socio-ambiental (Valero, 2019). En este artículo se expone un extracto de las reflexiones y resultados del trabajo doctoral sobre Pedagogía socio-ambiental (Valero, 2019) en particular los aspectos referenciales de la Educación Ambiental para la Sostenibilidad, el contexto de la Biorregión y las propiedades y dimensiones del Sitio de Vida. Finalmente se presentan las propuestas pedagógicas para el abordaje en el hecho práctico del concepto considerando como hilo conductor los procesos de reflexión-aprehensión-contextualización-acción por parte de los actores involucrados.
Bolaño o de las perspectivas de filosofar a Borges
Authors: Niebles Reales Eleucilio
Published: January 2025

El libro del profesor Adalberto Bolaño, Jorge Luis Borges. Del infinito a la posmodernidad, una mirada desde la filosofía contemporánea a su narrativa, comienza con un apartado interesante acerca de la historia de creación del libro mismo, y las motivaciones, intereses e ideas que lo rodearon. Igualmente, es una exposición atractiva sobre aquello que el libro se propone en sus distintos planos conceptuales, de tal suerte que desde el principio el lector puede ubicarse en cualquiera de los múltiples escenarios de lectura que el libro le sugiere.
Degradation and mechanical properties of concrete made with metallurgical sludge waste in long-term
Authors: Horňáková Marie , Pizoń Jan , Gołaszewski Jacek , Lehner Petr
Published: January 2025

Metallurgical sludge waste (MSW), a by-product of mining, energy, and metallurgical industries, has shown potential as a substitute for traditional aggregates. This research article focuses on studying the properties of concrete incorporating MSW itself and recycled concrete aggregate (RCA) containing MSW at both early and late ages. Great emphasis is placed here on the tests carried out one year after concreting. A total of ten concrete mix proportions were prepared with varying amounts of MSW and RCA, including a reference mix. In order to investigate the effects and role of MSW on the durability properties of concrete mixes, several laboratory tests, their numerical evaluation and energy dispersive spectroscopy were carried out. The investigation aims to provide insights into the performance, durability and long-term behaviour of MSW concrete.
Elaboración de proyectos de aula en psicología experimental usando animales como sujetos
Authors:   Universidad Cooperativa de Colombia, Lozada Celis Elkin Rodrigo , Martínez Barreto Aida Ingrith
Published: January 2025

Esta guía presenta algunas orientaciones para elaborar proyectos de aula en psicología experimental utilizando animales como sujetos. Primero se presentan algunos de los argumentos comúnmente utilizados para la experimentación con animales en psicología; después se da una definición del término conducta para los efectos de la presente guía; posteriormente, se desarrolla de manera breve la cuestión de la continuidad conductual entre especies para continuar con algunos de los aspectos más básicos del condicionamiento clásico y operante, y elementos normativos sobre el uso y el cuidado de animales en psicología experimental. Por último, se brinda una propuesta para la elaboración de proyectos de aula en psicología experimental usando animales como sujetos, describiendo cada uno de los apartados y consideraciones para tener en cuenta en este tipo de proyectos de aula.
Law and Dogmatics: Practical Applications
Authors:   Universidad Cooperativa de Colombia, Mogollón Anaya Nuby , Anaya Caraballo Liliana Rebeca , Hernández Hoyos David José
Published: January 2025

In this class note, the aim is to clarify the content and practical applications of the subject of legal dogmatics. It will delve deeply into matters concerning its conceptualization, epistemological nature, empiricism, and rationality. Legal dogmatics will be studied as a legal science, establishing its relationship with other sciences. Different sources of law will be analyzed, as well as the concept and structure of legal norms. A conceptual characterization of legal systems will be developed, including normative hierarchy. Finally, a thorough exploration of the legal order within the Colombian legal regime will be conducted, considering the main existing legal systems. Ultimately, the objective is to provide a detailed outline of the topics to be covered during Legal Dogmatics and how these contents can be practically applied in legal practice to address common situations in the legal profession.
Evaluación de la toxicidad en aguas residuales industriales tratadas por procesos biológicos utilizando bacterias luminiscentes
Authors: Rodríguez-Loaiza Diana C. , Ramírez-Henao Omaira , Peñuela-Mesa Gustavo A.
Published: January 2025

La toxicidad de las aguas residuales provenientes de empresas de procesamiento de productos cárnicos fue evaluada antes y después del tratamiento usando un reactor secuencial por lotes (SBR). Las pruebas de toxicidad fueron evaluadas mediante el análisis del efecto inhibidor de muestras en relación con la emisión de luz a partir de bacterias marinas de la especie Vibrio fischeri. Los resultados demostraron que los efluentes antes del tratamiento eran altamente tóxicos (EC50 < 60%), mientras que los resultados después del tratamiento mostraron baja o nula toxicidad (EC50 > 82%). En algunas etapas operativas del reactor SBR, se encontró correlación entre el nitrógeno amoniacal presente en cada muestra y la toxicidad de las aguas residuales tanto en el afluente y los efluentes, con correlaciones (R2) de 0,6141 y 0,8158, respectivamente. Como consecuencia de estos resultados, el sistema SBR puede ser considerado eficiente en la eliminación de materia orgánica y nitrógeno, y de ese modo disminuir la toxicidad en el agua tratada.
Expresión de moléculas HLA-DR, coestimuladoras y TLR9 en células presentadoras de antígenos circulantes de pacientes con lupus eritematoso sistémico (LES)
Authors: Zorro Soraya , Arango Liliana , Uribe Oscar , Ramírez Luis , García Luis , Vásquez Gloria
Published: January 2025

El LES es una enfermedad autoinmune sistémica con producción de autoanticuerpos anti dsDNA de manera Tdependiente1; por lo tanto, la participación de las células presentadoras de antígeno (APC), por las interacciones MHC:péptido-TCR, CD40-CD40L, CD80 y CD86 con CD28, es necesaria para el desencadenamiento de la respuesta autoinmune. En las APC, la regulación positiva de moléculas HLA-DR, CD40, CD80 y CD86 se da por estímulos endógenos (citoquinas) y exógenos (patógenos o sus productos)2. Dentro de éstos últimos están los dinucleótidos Citosina-Guanina hipometilados (CpG) presentes en DNA de procariotas que son reconocidos por el receptor TLR93. Sin embargo, los pacientes con LES presentan CpG circulantes de DNA propio, cuyo reconocimiento por TLR9 podría participar en la inducción de moléculas HLA-DR y coestimuladoras en las APC y por ende regular la activación de linfocitos T y B autorreactivos en estos pacientes.
Inducción de la enzima triptófano 2,3 dioxigenasa por glucocorticoides y su papel en la tolerancia materna al feto
Authors: Cadavid Lina , Cadavid Angela
Published: January 2025

El mecanismo por el cual la madre no rechaza al feto, sigue siendo una incógnita en la inmunología de la reproducción. Una de las hipótesis planteadas es la inmunosupresión mediada por el catabolismo del triptófano, el cual es un amino ácido sencial para la proliferación de los linfocitos T. Una de las nzimas que cataboliza el triptófano es la triptófano 2,3 ioxigenasa (TDO).La TDO es inducida por los glucocorticoides en el hígado, pero aún no se conoce si estos inducen la producción de la TDO n la interfase materno fetal al interactuar con los receptores resentes en células estromales y NK; En un modelo murino, e observó que la TDO se expresa en la interfase materno etal con un pico que coincide con el de mayor actividad de egradación del triptófano, sugiriendo entonces que esta nzima puede estar involucrada en la tolerancia materna al feto.
Determinación de la profundidad y duración de la neutropenia inducida por ciclofosfamida en ratones hembras MPF de la cepa Udea: ICR(cd-1)
Authors: Salazar Beatriz , Zuluaga Andrés , Rodriguez Carlos , Agudelo María , Vesga Omar
Published: January 2025

El modelo murino de infección del muslo emplea animales neutropénicos para poder determinar la eficacia intrínseca de los antibióticos in vivo. Sin embargo, no se ha definido el número de neutrófilos y la duración de la neutropenia inducida por ciclofosfamida (CFM) intraperitoneal (IP), información fundamentalpara valorar la reproducibilidad y confiabilidad del modelo.
Method of Collaboration between Humans and Generative Artificial Intelligence in the Development of Information Systems
Authors:   Petrozavodsk State University, Petrozavodsk, 185910, Russian Federation, Rego G. E. , Pitukhin E. A. ,   Petrozavodsk State University, Petrozavodsk, 185910, Russian Federation
Published: January 2025

We propose a method for information system (IS) design with a focus on the applicability of intelligent chatbots. An analysis of existing chatbots shows that current solutions do not have the ability to formulate IS requirements during designing without human intervention. The study proposes to integrate ChatGPT (GPT4 model) as a chatbot to solve the problem of writing requirements elicitation for IS. The proposed method for solving the problem is based on a gradual reduction in entropy of chatbot response, which can be achieved by controlling such basic query parameters as the form, depth and breadth of the prompt. Based on the proposed method, an algorithm for controling prompts during a dialogue with a chatbot was developed, regulating the form, depth and breadth of the question to obtain the required level of content in the answer. The following results were obtained during the study: a method for obtaining new knowledge based on entropy of chatbot response reduction; algorithm for prompts control; the second phase of IS development is automated (including identification of business requirements and system objectives; analysis of existing solutions and technologies; determination of functional requirements and system capabilities; development of system architecture, including service definition and interaction; creation of interfaces for service interaction; establishment of a data model and database and formulation of business process logic). The method was tested to design an IS to support strategic decision making in the forestry industry. The design results received a positive assessment from experts. Analysis of the obtained results revealed the advantages and limitations of using chatbots as co-pilots in the design of IS and outlined directions for future research.
Implementation of a Feedback System for Myoelectric Prostheses of the Upper Limb
Authors:   Voronezh State University, Voronezh, 394018, Russian Federation, Turovsky Ya. A. ,   Russian Academy of Sciences, Moscow, 117997, Russian Federation, Borzunov S. V. ,   Voronezh State University, Voronezh, 394018, Russian Federation, Krupenin S. S. ,   Voronezh State University, Voronezh, 394018, Russian Federation, Mironkin A. P. ,   Voronezh State University, Voronezh, 394018, Russian Federation, Tokarev R. A. ,   Voronezh State University, Voronezh, 394018, Russian Federation
Published: January 2025

The feedback system is presented in the aspect of its software and hardware support, necessary for the synthesis of such an information system as applied to a myoelectric prosthesis. The most successful configurations of sensors, micro­controllers, actuators from the standpoint of software and hardware implementation are defined and designed. Approaches to the installation and location of tactile actuators on the surface of the hand are designed, which determine the optimal number of elements depending on the anatomical features of the stump. Based on this approach, an information system for training the user to work with myoelectric prostheses was created, using virtual reality technology.
Spinal anesthesia as a method of choosing anesthetic support for arthroscopic cruciate ligament repair and its effect on postoperative analgesia: single-center prospective cohort study
Authors: Gorelov Danil V. , Ovechkin Alexei M. , Babayants Andrey V. , Ignatenko Olga V.
Published: January 2025

BACKGROUND: The increasing number of arthroscopic surgeries of the cruciate ligaments, particularly outpatient procedures, makes necessary the search for the most efficient methods of anesthesia for these operations.
OBJECTIVE: Evaluation of safety and efficiency of spinal anesthesia as a method during arthroscopic cruciate ligament repair surgery.
MATERIALS AND METHODS: The study included 52 patients who underwent arthroscopic plastic surgery for cruciate ligament repair under spinal anesthesia. In the postoperative period, pain syndrome intensity at rest and during movement was assessed using a visual analog scale (VAS) 4, 8, 12, 16, 20, and 24 hours after surgery. The need for opioid analgesics and their total dose were recorded, as well as the time before first request for analgesia, time for motor block restoration to level 1 on Bromage scale, and time of the first rise from bed. Spinal anesthesia effect on intraoperative hemodynamics, heart rate, duration of spinal anesthesia, surgery, and nonsteroidal anti-inflammatory drug dose during hospitalization were studied. Complications and undesirable effects of anesthesia were also evaluated along with duration of hospitalization. Patients' satisfaction with anesthesia and the quality of postoperative care was also assessed.
RESULTS: when assessing the pain syndrome, significant differences were found in the level of pain at rest and during activation (p 0.001, R = 0,8). We found that 82.6% (n = 43) of patients required the prescription of opioid drugs in the postoperative period. Of these, 18% (n=8) were prescribed opioid medication two or more times. The frequency of opioid use was directly proportional to the level of pain (p 0.001, R=0,7). The need for the first administration of analgesics arose in patients after an average of 178 minutes, with a recovery time for motor block of 134 minutes. Patients first rise from bed on average was more than three hours after the operation.
CONCLUSION: the pronounced pain syndrome, lack of early activation, presence of side effects of anesthesia, transfered of arthroscopic surgeries to the category of "day surgery" - all these factors explain the need for search for other anesthesia methods that don`t have spinal anesthesia disadvantages and allow for prolonged postoperative analgesia.
A Panel analysis of the Factors Affecting Economic Growth : A Focus on Logistics Performance
Authors:   The Korean Logistics Research Association, Kang Min-Hyoa , Stephens, Aaron Raeb Stephens, Aaron Raeb , Robb, Charles Arthurc Robb, Charles Arthurc
Published: January 2025

This study investigates the determinants of economic performance, measured through GDP and GDP per capita growth, among the top 30 logistics-performing countries from 2007 to 2022. Using a robust panel analysis framework, the research explores the impact of foreign direct investment (FDI) inflows, research and development (R&D) expenditure, information and communication technology (ICT) outflows, government efficiency, and logistics performance on economic outcomes. Drawing from endogenous growth theory, technology-based trade theory, and new institutional economics, the study develops a comprehensive theoretical model that encapsulates the multifaceted influences of technological advancement, institutional quality, and economic resilience. Additionally, the analysis incorporates the effects of the 2008 financial crisis and the COVID-19 pandemic as control variables to understand their disruptions on economic stability. The findings reveal that FDI, R&D, and ICT outflows significantly positively affect GDP growth, while government efficiency and logistics performance are critical enablers of sustained economic success. The results underscore the importance of strategic investments in technology and institutional capacity for enhancing global competitiveness. This research offers crucial insights for policymakers and stakeholders, emphasizing the need for balanced sectoral development and robust crisis management frameworks to bolster economic resilience.
Combining Multisite Tsunami and Deformation Modeling to Constrain Slip Distributions for the 1700 C.E. Cascadia Earthquake
Authors: Small David T. , Melgar Diego , La Selle SeanPaul , Meigs Andrew
Published: January 2025

A major earthquake ruptured the Cascadia subduction zone (CSZ) on 26 January 1700. Key paleoseismic evidence associated with this event include tsunami deposits, stratigraphic evidence of coastal coseismic subsidence, written Japanese records of a tsunami unaccompanied by earthquake shaking, and margin-wide turbidites found offshore and in lacustrine environments. Despite this wealth of independent clues, important details about this event remain unresolved. Dating uncertainties do not conclusively establish whether the proxies are from one earthquake or a sequence of them, and we have limited knowledge of the likely slip distributions of the event or events. Here, we use a catalog of 37,500 candidate synthetic ruptures between Mw 7.8 and 9.2 and simulate their resulting coseismic deformation and tsunami inundation. Each model is then compared against estimated Japan tsunami arrivals, regional coastal subsidence records, and local paleotsunami deposits mapped at six different coastal marshes and one coastal lake along the CSZ. We find that seven full-margin ruptures with a median magnitude of Mw 9.1 satisfy all three constraints. We favor one Mw 9.11 model that best matches all site paleoseismic observations and suggests that the Cascadia megathrust slipped up to ∼30 m and must have shallow geodetic coupling. We also find that some sequences composed of three or four ruptures can still satisfy the observations, yet no sequences of two ruptures can. Sequences are differentiated into three groups based on whether they contain a mainshock rupture located in the south (>44° N) or further north. All sequences contain unruptured portions of the megathrust and most contain mainshocks with peak slip above 40 m. The fit of the geologic evidence from sequences is poor in comparison to single-event models. Therefore, sequences are generally less favored compared to full-margin events.
The Relationship Between Project-Based Creative Learning and Well-Being Focusing on Whole Personality Development in Teacher Education. A Case Study
Authors: Vass Vilmos , Mészáros Tímea
Published: January 2025

In this research paper, we seek to examine how participation in a community art project can promote positive psychological and social outcomes. We aim to outline the processes through which the experience of participation in community arts is transformed into positive personal developmental outcomes.In order to give evidences and examples of this relationship and balance, this research study focuses on some models of creativity and case study in teacher education on the base of community arts. In Slovakia, community art has not yet drawn significant research attention in regards to its potential as a creativity development strategy in higher education. A gap remains in understanding how and why students’s participation in a community art project can lead to those positive outcomes. Aiming to respond to this gap, the following research exploredthe meaning of creativity and whole personality development in a community art project from the point of the students who experienced it. Twelve participants were interviewed about their experiences in a community art project (University Totem) held in Komárno, Slovakia. The findings highlighted the potential of community arts projects for promoting the creative process and community building through learning various clay-making techniques. Finally, at the end of the research paper, we will draw conclusions and summarize our paper.
Career Counseling in Early Childhood Education
Authors: Barańska Magdalena
Published: January 2025

The aim of this article is to outline how career guidance classes in early childhood education can be valuable for lifelong development. Career counselling is still strongly associated with helping adults, the unemployed, to retrain. It is treated as an expert service primarily related to the labour market. Career counselling should be disenchanted. Undoubtedly, it is a professional service, but it is equally firmly inscribed in the educational process. According to the core curriculum, one of the tasks of the school is to prepare students to choose their further education and profession. The school runs vocational guidance classes, which fit in with lifelong learning. Due to the approaching transition from primary to secondary school, much attention is paid to counselling classes for seventh and eighth graders. However, developing interests and getting to know oneself starts much earlier, so it is worth weaving elements of vocational knowledge into the process.
Improper Fitting Personal Protective Clothing and Subsequent Countermeasures for
Physical Conditioning in Female Firefighters
Authors: Sell Katie , Abel Mark , Dawes J. Jay , Thompson Megan , Zapp Annette , Pottorf Ofra , Bernardi Lilly , Prendergast James
Published: January 2025

The purpose of this paper was to 1) use an explorative literature overview to identify
issues related to ill-fitting clothing and occupational gear for female firefighters,
and 2) use an inductive approach to develop generalizable recommendations for exercise
professionals to utilize by identifying significant themes in published peer reviewed
articles related to movement and injury risk. Research, including both qualitative and
quantitative approaches, has shown that the majority of current personal protective
clothing (PPC) and operational gear was developed to fit a limited array of male
physiques. Consequently, the improper fit of PPC and gear has presented numerous
concerns that, if not addressed, will continue to present unnecessary occupational
challenges and risk to firefighters, especially female firefighters. These issues
include, but are not limited to, an increased risk of hazardous material exposure,
elevated thermoregulatory challenges, higher injury risk due compensatory biomechanical
movement during occupational tasks, and lower self-efficacy and emotional well-being.
Countermeasures for physical conditioning that target injury risk factors or other
issues associated with improper fitting of PPC and gear may include strengthening and
stabilizing specific joints or regions of the body (e.g., core, shoulder, and back),
reducing health-related risk factors that magnify issues (e.g., body composition), and
consulting with a certified exercise professional (e.g., TSAC-F) for program
development. Although ongoing research is still needed, the data and subsequent
recommendations provided may present valuable insight into injury risk reduction and
individualized exercise training considerations for female firefighters that take into
consideration improper PPC fit.
Assessment of salivary parameters and oral microbiota in amateur swimmers
Authors: Santos Meyfarth Sandra Regina , Latini Abreu Mariana Gouvêa , da Silva Moura Pedro Antônio , Von Held Marques Rodrigo , Corrêa Póvoa Helvécio Cardoso , Lopes Pontes Póvoa Iorio Natalia , Azeredo Alves Antunes Lívia , Santos Antunes Leonardo
Published: January 2025

Objectives: The growing diffusion of sports activities is centering attention on the development of diseases correlated with sports performance. The most common diseases reported by sswimmers are dental stains. They are also exposed to the onset of erosive tooth wear and harbor cariogenic bacteria. Considering that the oral cavity of swimmers is in close contact with the swimming pool water in their daily training environment, this study aimed to evaluate whether swimming can change salivary parameters and oral microbiota of amateur athletes.
Material and method: This before-after study included 18 amateur athletes between 10 to 18 years old from a Swimming Team who practiced the sport at least three times a week. The swimmers were interviewed by a questionnaire and clinically evaluated. Unstimulated saliva was collected before and immediately after swimming. The salivary flow, pH, and buffer capacity were evaluated. The microbiological analysis included: total microorganisms, mutans streptococci group, Lactobacillus spp., and Candida spp. Wilcoxon test was applied before and after swimming with 5% level of significance.
Results: A total of 18 subjects participated in this study. All of the pool parameters were under acceptable limit. There was no statistical difference in the salivary parameters: salivary flow (P = 0.264), pH (P = 0.132); buffer capacity (P = 0.067). Regarding the oral microbiota, no significant differences were found before and after swimming for mutans streptococci group (P = 0.950), Lactobacillus spp. (P = 0.432), Candida spp. (P = 0.386), and total microorganisms (P = 0.332).
Conclusion: No change was observed in the salivary parameters and the oral microbiota before and after swimming in the evaluated group.