bluuebunny/crossref_metadata_2025 huggingface dataset:
Annihilator intersection graph of a lattice
Authors: Kulal Vikas , Khairnar Anil , Tamizh Chelvam T.
Published: April 2024

For a lattice [Formula: see text], we associate a graph called the annihilator intersection graph of [Formula: see text], denoted by [Formula: see text] The vertex set of [Formula: see text] is the set of all nonzero zero-divisors of [Formula: see text] and any two distinct vertices [Formula: see text] and [Formula: see text] are adjacent in [Formula: see text] if and only if [Formula: see text]. It has shown that the [Formula: see text] is disconnected if and only if the number of atoms in [Formula: see text] is two. If [Formula: see text] is connected, then we determine the diameter and the girth of [Formula: see text] We characterize all lattices whose annihilator intersection graph is planar. Further, we obtain the clique number and chromatic number of [Formula: see text] when [Formula: see text] is a finite Boolean lattice. We show that the domination number of [Formula: see text] is not exceeding two. Finally, we obtain a condition under which the annihilator intersection graph is identical with the zero-divisor graph and the annihilator ideal graph of lattices.
DANSEN: Database Acceleration on Native Computational Storage by Exploiting NDP
Authors: Tamimi Sajjad , Bernhardt Arthur , Stock Florian , Petrov Ilia , Koch Andreas
Published: April 2024

This article introduces
DANSEN
, the hardware accelerator component for neoDBMS, a full-stack computational storage system designed to manage on-device execution of database queries/transactions as a Near-Data Processing (NDP)-operation. The proposed system enables Database Management Systems (DBMS) to offload NDP-operations to the storage while maintaining control over data through a
native storage interface
.
DANSEN
provides an NDP-engine that enables DBMS to perform both low-level database tasks, such as performing database administration, as well as high-level tasks like executing SQL,
on
the smart storage device while observing the DBMS concurrency control. Furthermore,
DANSEN
enables the incorporation of custom accelerators as an NDP-operation (e.g., to perform hardware-accelerated ML inference directly on the stored data). We built the
DANSEN
storage prototype and interface on an UltraScale+HBM FPGA and fully integrated it with PostgreSQL 12. Experimental results demonstrate that the proposed NDP approach outperforms software-only PostgreSQL using a fast off-the-shelf NVMe drive and significantly improves the end-to-end execution time of an aggregation operation (similar to Q6 from CH-benCHmark, 150 million records) by ≈ 10.6×. The versatility of the proposed approach is also validated by integrating a compute-intensive data analytics application with multi-row results, outperforming PostgreSQL by ≈ 1.5×.
Universal Relocalizer for Weakly Supervised Referring Expression Grounding
Authors: Zhang Panpan , Liu Meng , Song Xuemeng , Cao Da , Gao Zan , Nie Liqiang
Published: April 2024

This article introduces the Universal Relocalizer, a novel approach designed for weakly supervised referring expression grounding. Our method strives to pinpoint a target proposal that corresponds to a specific query, eliminating the need for region-level annotations during training. To bolster the localization precision and enrich the semantic understanding of the target proposal, we devise three key modules: the category module, the color module, and the spatial relationship module. The category and color modules assign respective category and color labels to region proposals, enabling the computation of category and color scores. Simultaneously, the spatial relationship module integrates spatial cues, yielding a spatial score for each proposal to enhance localization accuracy further. By adeptly amalgamating the category, color, and spatial scores, we derive a refined grounding score for every proposal. Comprehensive evaluations on the RefCOCO, RefCOCO+, and RefCOCOg datasets manifest the prowess of the Universal Relocalizer, showcasing its formidable performance across the board.
A Mixed-Criticality Traffic Scheduler with Mitigating Congestion for CAN-to-TSN Gateway
Authors: Yan Wenyan , Wei Dongsheng , Fu Bin , Li Renfa , Xie Guoqi
Published: April 2024

The network architecture that Time-Sensitive Networking (TSN) is used as the backbone network and the Controller Area Network (CAN) serves as the intra-domain network is considered as the CAN-TSN interconnection network architecture, which has gained considerable attention within industrial embedded networks, such as spacecraft, intelligent automobiles, and factory automation. The architecture employs the CAN-TSN gateway as a central hub for transmitting and managing a significant volume of communications between the CAN domains and TSN. However, the CAN-TSN gateway faces a high congestion challenge due to the rapid growth in data volume, making it difficult to effectively support different time planning mechanisms provided by TSN. In this article, we propose a two-stage mixed-criticality traffic scheduler. The scheduler in the first stage adopts a Message Optimization Algorithm (MOA) to aggregate multiple CAN messages into a single TSN message (including the aggregation of critical and non-critical CAN messages), which reduces the number of CAN messages requiring transmission. In the second stage, the scheduler proposes a Message Scheduling Optimization Algorithm (MSOA) to schedule critical TSN messages. This algorithm reassembles all the critical CAN messages (within the un-schedulable TSN messages) to generate new TSN messages for rescheduling. Experimental results show that our proposed scheduler effectively improves the acceptance ratio of critical and non-critical CAN messages and outperforms the state-of-the-art message scheduling method in terms of acceptance ratio while improving the bandwidth utilization and the number of schedule table entries. We further construct a hardware platform to evaluate the performance of MSOA. The consistency between practical results and theoretical results shows the effectiveness of MSOA.
Intelligent Edge-powered Data Reduction: A Systematic Literature Review
Authors: Pioli Laércio , de Macedo Douglas D. J. , Costa Daniel G. , Dantas Mario A. R.
Published: April 2024

The development of the Internet of Things (IoT) paradigm and its significant spread as an affordable data source has brought many challenges when pursuing efficient data collection, distribution, and storage. Since such hierarchical logical architecture can be inefficient and costly in many cases, Data Reduction (DR) solutions have arisen to allow data preprocessing before actual transmission. To increase DR performance, researchers are using Artificial Intelligence (AI) techniques and models toward reducing sensed data volume. AI for DR on the edge is investigated in this study in the form of a Systematic Literature Review (SLR) encompassing major issues such as data heterogeneity and AI-based techniques to reduce data, architectures, and contexts of usage. An SLR is conducted to map the state of the art in this area, highlighting the most common challenges and potential research trends in addition to a proposed taxonomy.
Oxygen Reaction of Nonlayered Tetrahedral KFeO2 Positive Electrode for Potassium-Ion Battery Using an FSA-based Ionic Liquid Electrolyte
Authors: Jiao Kai , Yamamoto Takayuki , Kiuchi Hisao , Zhao Haochong , Nohira Toshiyuki
Published: April 2024

K-ion batteries (KIBs) that use ionic liquid (IL) electrolytes are promising candidates for post-Li-ion batteries because of the abundance of potassium resources and safety of ILs. We successfully synthesized stoichiometric KFeO2 using a solid-state method and evaluated its charge–discharge performance as a KIB positive electrode material, with an amide-based IL electrolyte at 298 K. Transmission electron microscopy, X-ray photoelectron spectroscopy, synchrotron soft X-ray absorption spectroscopy, and energy-dispersive X-ray spectroscopy data showed that the bulk redox and surface oxidation of oxygen, rather than those of iron, contribute to the reversible and irreversible capacities, respectively. Capacity decay occurred upon repeated cycling, owing to the surface irreversible oxidation of oxygen ions to form O2 and K1−x
FeO2−x/2, which blocks the pathways of K+ transfer to KFeO2 particles. This study provides a vital platform for constructing novel KIBs and elucidates the important role of oxygen in KFeO2 positive electrode.
Examining Performance Loss Mechanisms in Lithium-Ion Batteries with the High-Voltage Mn-Rich Spinel Positive Electrodes
Authors: Badami Pavan P. , Trask Stephen E. , Son Seoung-Bum , Rodrigues Marco-Tulio F. , Abraham Daniel P.
Published: April 2024

The high-voltage spinel, with the nominal composition of LiNi0.5-xMn1.5+xO4 (LNMO), could be a sustainable alternative to the layered-oxide positive electrodes used in lithium-ion batteries. However, commercial acceptance has been limited as LNMO cells display rapid performance loss during cycling. To examine reasons for this loss we prepared cells with LNMO-based positive and either graphite or lithium titanate (LTO) based negative electrodes. Our initial cells displayed high impedance and rapid impedance rise during cycling. Adding single walled carbon nanotubes in the positive lowered initial cell impedance but impedance increased during cycling because of coating delamination from the Al foil. Using a primed Al current collector solved the delamination problem: cells with this current collector showed only a small impedance rise. Regarding capacity, cells with the LTO negative showed higher initial capacities and smaller fade. Our data indicate that cell capacity retention is determined by reduction reactions at the negative electrode that lower capacity and oxidation reactions at the positive electrode that increase capacity: both types of reactions deplete the cell electrolyte during extended cycling. All things considered, species generated at high voltages, either in the electrolyte or at the LNMO electrode, drive cell capacity fade.
Combined cardiovascular effects of ovariectomy and high-intensity interval training in female spontaneously hypertensive rats
Authors: Krzesiak Amandine , Enea Carina , Faivre Jean-François , Bescond Jocelyn , Vanderbrouck Clarisse , Cognard Christian , Sebille Stéphane , Bosquet Laurent , Delpech Nathalie
Published: April 2024

This study reports the effects of high-intensity interval exercise (HIIE) training on cardiac and endothelial function in female hypertensive rats. Despite a lack of effect on blood pressure (BP), HIIE training induces eccentric cardiac remodeling with greater functionals effects. Furthermore, training has beneficial effects on endothelial function. However, ovarian hormones do not seem to modulate cardiac and aortic adaptations to this training modality. All this underlines the need to consider training modalities on the cardiovascular system in women.
Reverse Model for Curved Bridge Measurement Based on 3D Laser Scanning Technology
Authors: Chen Xin , Chen Lihang , Liang Dong
Published: April 2024

Receiving inspection plays a crucial role in ensuring construction quality after the completion of engineering projects. Traditional inspection measurement methods, such as manual observation means and optical equipment measurement methods, have limitations in terms of the number of measurement sites and the range of measurements. These traditional methods fail to provide accurate curve parameters and continuous spatial morphology information for large‐span curved bridge structures. This paper proposes a reverse model measurement method to address this issue. The reverse model is built based on point cloud data acquired by 3D laser scanning technology. Finally, take the Taizicheng No. 1 Bridge as an example, the validity of the proposed method is verified.
“You’ve Got to Connect with the People”: The Meaning of, Preferences for, and Involvement in Social Participation for Older People Living in Nursing Homes in Victoria, Australia
Authors: Rayner Jo-Anne , Fetherstonhaugh Deirdre , McAuliffe Linda , Clune Samantha
Published: April 2024

This research sought to explore the meaning of, preferences for, and involvement in social participation for older people living in nursing homes in Victoria, Australia. A qualitative descriptive study using semistructured interviews with twenty older people living in four geographically and ethnically diverse nursing homes was conducted between 2020 and 2022. Interview transcripts were thematically analysed. All the older people had been very socially active before moving into aged care and had participated in leisure and volunteering activities. Five themes emerged from the data analysis related to the meaning of, preferences for, and involvement in activities for social participation. The meaning of social participation among these older people varied. Some participated in group activities to keep active and busy, while others were content with interests of their own. Social participation in group activities provided older people with a connection to others and assisted in maintaining existing, or developing new, relationships. However, the ability to participate in group activities that offered opportunities for social participation was limited by age‐related decline for some older people. The COVID‐19 pandemic restrictions constrained activities, which provided opportunities for social participation for some older people living in nursing homes, but not all. These perspectives highlight the need for individualised person‐centred opportunities for social participation in nursing homes. Group activities should enable older people to remain active and facilitate social connections that provide meaning and purpose. Respect for individual choice is important, as older people are not a homogeneous group, and opportunities to pursue individual activities should be facilitated.
Supplementary Table S9 from Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy
Authors: Mukhopadhyay Suman , Huang Hsin-Yi , Lin Ziyan , Ranieri Michela , Li Shuai , Sahu Soumyadip , Liu Yingzhuo , Ban Yi , Guidry Kayla , Hu Hai , Lopez Alfonso , Sherman Fiona , Tan Yi Jer , Lee Yeuan Ting , Armstrong Amanda P. , Dolgalev Igor , Sahu Priyanka , Zhang Tinghu , Lu Wenchao , Gray Nathanael S. , Christensen James G. , Tang Tracy T. , Velcheti Vamsidhar , Khodadadi-Jamayran Alireza , Wong Kwok-Kin , Neel Benjamin G.
Published: April 2024

Supplementary Table S9
RPPA data from MRTX-849/SHP099-resistant tumor nodules in KCL mice
Supplementary Table S7 from Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy
Authors: Mukhopadhyay Suman , Huang Hsin-Yi , Lin Ziyan , Ranieri Michela , Li Shuai , Sahu Soumyadip , Liu Yingzhuo , Ban Yi , Guidry Kayla , Hu Hai , Lopez Alfonso , Sherman Fiona , Tan Yi Jer , Lee Yeuan Ting , Armstrong Amanda P. , Dolgalev Igor , Sahu Priyanka , Zhang Tinghu , Lu Wenchao , Gray Nathanael S. , Christensen James G. , Tang Tracy T. , Velcheti Vamsidhar , Khodadadi-Jamayran Alireza , Wong Kwok-Kin , Neel Benjamin G.
Published: April 2024

Supplementary Table S7
RPPA from MTRX-849-resistant tumor nodules from KCL mice
Supplementary Table S11 from Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy
Authors: Mukhopadhyay Suman , Huang Hsin-Yi , Lin Ziyan , Ranieri Michela , Li Shuai , Sahu Soumyadip , Liu Yingzhuo , Ban Yi , Guidry Kayla , Hu Hai , Lopez Alfonso , Sherman Fiona , Tan Yi Jer , Lee Yeuan Ting , Armstrong Amanda P. , Dolgalev Igor , Sahu Priyanka , Zhang Tinghu , Lu Wenchao , Gray Nathanael S. , Christensen James G. , Tang Tracy T. , Velcheti Vamsidhar , Khodadadi-Jamayran Alireza , Wong Kwok-Kin , Neel Benjamin G.
Published: April 2024

Supplementary Table S11
Differential gene expression analysis of scRNA-seq data from tumor cluster in patient #2349 (MRTX-849/TNO155-resistant) vs patient #1566 (control, KRASG12V tumor)
Supplementary Table S10 from Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy
Authors: Mukhopadhyay Suman , Huang Hsin-Yi , Lin Ziyan , Ranieri Michela , Li Shuai , Sahu Soumyadip , Liu Yingzhuo , Ban Yi , Guidry Kayla , Hu Hai , Lopez Alfonso , Sherman Fiona , Tan Yi Jer , Lee Yeuan Ting , Armstrong Amanda P. , Dolgalev Igor , Sahu Priyanka , Zhang Tinghu , Lu Wenchao , Gray Nathanael S. , Christensen James G. , Tang Tracy T. , Velcheti Vamsidhar , Khodadadi-Jamayran Alireza , Wong Kwok-Kin , Neel Benjamin G.
Published: April 2024

Supplementary Table S10
Differential gene expression analysis of scRNA-seq data from tumor cluster in patient #1778 (AMG-510-resistant tumor) vs patient #1566 (control, KRASG12V tumor)
Supplementary Table S3 from XTX301, a Tumor-Activated Interleukin-12 Has the Potential to Widen the Therapeutic Index of IL12 Treatment for Solid Tumors as Evidenced by Preclinical Studies
Authors: Patel Ekta , Malkova Natalia V. , Crowe David , Pederzoli-Ribeil Magali , Fantini Damiano , Fanny Manoussa , Madala Hanumantha Rao , Jenkins Kurt A. , Yerov Oleg , Greene Justin , Guzman Wilson , O'Toole Caitlin , Taylor Jacob , O'Donnell Rebekah K. , Johnson Parker , Lanter Bernard B. , Ames Brian , Chen Jia , Vu Sallyann , Wu Hsin-Jung , Cantin Susan , McLaughlin Megan , Hsiao Yu-Shan S. , Tomar Dheeraj S. , Rozenfeld Raphael , Thiruneelakantapillai Lakshmanan , O'Hagan Ronan C. , Nicholson Benjamin , O'Neil Jennifer , Bialucha Carl Uli
Published: April 2024

Supplementary Table S3: IFN-γ production EC50 in mouse, human, and cynomolgus primary cells
The ability of mXTX301 to induce IFN-γ production in mouse splenocytes and XTX301 to induce IFN-γ production in human and cynomolgus monkey PBMCs was assessed via ELISA. The EC50 was calculated as described in the statistical analysis section.
Supplementary Table S2 from XTX301, a Tumor-Activated Interleukin-12 Has the Potential to Widen the Therapeutic Index of IL12 Treatment for Solid Tumors as Evidenced by Preclinical Studies
Authors: Patel Ekta , Malkova Natalia V. , Crowe David , Pederzoli-Ribeil Magali , Fantini Damiano , Fanny Manoussa , Madala Hanumantha Rao , Jenkins Kurt A. , Yerov Oleg , Greene Justin , Guzman Wilson , O'Toole Caitlin , Taylor Jacob , O'Donnell Rebekah K. , Johnson Parker , Lanter Bernard B. , Ames Brian , Chen Jia , Vu Sallyann , Wu Hsin-Jung , Cantin Susan , McLaughlin Megan , Hsiao Yu-Shan S. , Tomar Dheeraj S. , Rozenfeld Raphael , Thiruneelakantapillai Lakshmanan , O'Hagan Ronan C. , Nicholson Benjamin , O'Neil Jennifer , Bialucha Carl Uli
Published: April 2024

Supplementary Table S2: pSTAT4 EC50 in HEK-Blue IL-12 RGA and primary CD8 T cells
IL-12 HEK-Blue reporter gene cells were incubated with either rh IL-12, unmasked control, or XTX301 at varying doses, and the reporter activity was measured. The data from three independent experiments, the average of replicates from each experiment are listed in the table. Pre-activated primary human PBMCs were incubated with either rhIL-12, unmasked control or XTX301 at varying doses, and STAT4 phosphorylation was assessed in CD8+ T cells via flow cytometry. The EC50 was calculated as described in the statistical analysis section. The data represents two independent experiments, each conducted with two different PBMC donors.
Supplementary Figure S6 from XTX301, a Tumor-Activated Interleukin-12 Has the Potential to Widen the Therapeutic Index of IL12 Treatment for Solid Tumors as Evidenced by Preclinical Studies
Authors: Patel Ekta , Malkova Natalia V. , Crowe David , Pederzoli-Ribeil Magali , Fantini Damiano , Fanny Manoussa , Madala Hanumantha Rao , Jenkins Kurt A. , Yerov Oleg , Greene Justin , Guzman Wilson , O'Toole Caitlin , Taylor Jacob , O'Donnell Rebekah K. , Johnson Parker , Lanter Bernard B. , Ames Brian , Chen Jia , Vu Sallyann , Wu Hsin-Jung , Cantin Susan , McLaughlin Megan , Hsiao Yu-Shan S. , Tomar Dheeraj S. , Rozenfeld Raphael , Thiruneelakantapillai Lakshmanan , O'Hagan Ronan C. , Nicholson Benjamin , O'Neil Jennifer , Bialucha Carl Uli
Published: April 2024

Supplemental Figure S6: XTX301 induced cell signature and pathway analysis: single-sample Gene Set Enrichment Analysis (ssGSEA) was performed for all samples and for selected gene sets of interest (see figure 5e). Each ssGSEA score summarizes the overall expression level of genes involved in a certain biological process of interest in a biological sample. For each gene set, ssGSEA scores were analyzed with respect to treatment groups and significant differences compared to the vehicle group were determined by Wilcoxon rank sum test. Boxplots showing ssGSEA scores (y-axis) of all samples for gene sets of interest. Each point is a sample. Samples were grouped by treatment group (x-axis). Colors indicate different treatment groups. * (Wilcoxon test, p< 0.05) ** (Wilcoxon test, p<0.01).
Supplementary Figure S4 from XTX301, a Tumor-Activated Interleukin-12 Has the Potential to Widen the Therapeutic Index of IL12 Treatment for Solid Tumors as Evidenced by Preclinical Studies
Authors: Patel Ekta , Malkova Natalia V. , Crowe David , Pederzoli-Ribeil Magali , Fantini Damiano , Fanny Manoussa , Madala Hanumantha Rao , Jenkins Kurt A. , Yerov Oleg , Greene Justin , Guzman Wilson , O'Toole Caitlin , Taylor Jacob , O'Donnell Rebekah K. , Johnson Parker , Lanter Bernard B. , Ames Brian , Chen Jia , Vu Sallyann , Wu Hsin-Jung , Cantin Susan , McLaughlin Megan , Hsiao Yu-Shan S. , Tomar Dheeraj S. , Rozenfeld Raphael , Thiruneelakantapillai Lakshmanan , O'Hagan Ronan C. , Nicholson Benjamin , O'Neil Jennifer , Bialucha Carl Uli
Published: April 2024

Supplemental Figure S4: Gating strategy for multi-color flow cytometry analysis of tumor-infiltrating and splenic immune cell populations.
Supplementary Table S6 from Single-Cell RNA Sequencing Unifies Developmental Programs of Esophageal and Gastric Intestinal Metaplasia
Authors: Nowicki-Osuch Karol , Zhuang Lizhe , Cheung Tik Shing , Black Emily L. , Masqué-Soler Neus , Devonshire Ginny , Redmond Aisling M. , Freeman Adam , di Pietro Massimilliano , Pilonis Nastazja , Januszewicz Wladyslaw , O'Donovan Maria , Tavaré Simon , Shields Jacqueline D. , Fitzgerald Rebecca C.
Published: April 2024

This table contains marker genes identified in the pairwise comparison of clusters identified in fibroblast population
Supplementary Table S5 from Single-Cell RNA Sequencing Unifies Developmental Programs of Esophageal and Gastric Intestinal Metaplasia
Authors: Nowicki-Osuch Karol , Zhuang Lizhe , Cheung Tik Shing , Black Emily L. , Masqué-Soler Neus , Devonshire Ginny , Redmond Aisling M. , Freeman Adam , di Pietro Massimilliano , Pilonis Nastazja , Januszewicz Wladyslaw , O'Donovan Maria , Tavaré Simon , Shields Jacqueline D. , Fitzgerald Rebecca C.
Published: April 2024

This table contains details of mutations identified in WGS of E-GM samples.
Supplementary Table S3 from Single-Cell RNA Sequencing Unifies Developmental Programs of Esophageal and Gastric Intestinal Metaplasia
Authors: Nowicki-Osuch Karol , Zhuang Lizhe , Cheung Tik Shing , Black Emily L. , Masqué-Soler Neus , Devonshire Ginny , Redmond Aisling M. , Freeman Adam , di Pietro Massimilliano , Pilonis Nastazja , Januszewicz Wladyslaw , O'Donovan Maria , Tavaré Simon , Shields Jacqueline D. , Fitzgerald Rebecca C.
Published: April 2024

This table contains marker genes identified in the pairwise comparison of clusters defined as columnar cells.
Supplementary Table S2 from Single-Cell RNA Sequencing Unifies Developmental Programs of Esophageal and Gastric Intestinal Metaplasia
Authors: Nowicki-Osuch Karol , Zhuang Lizhe , Cheung Tik Shing , Black Emily L. , Masqué-Soler Neus , Devonshire Ginny , Redmond Aisling M. , Freeman Adam , di Pietro Massimilliano , Pilonis Nastazja , Januszewicz Wladyslaw , O'Donovan Maria , Tavaré Simon , Shields Jacqueline D. , Fitzgerald Rebecca C.
Published: April 2024

This table contains marker genes identified in each cluster of cells.
Supplementary Table 3 from Immune Modulation with RANKL Blockade through Denosumab Treatment in Patients with Cancer
Authors: Chang Hewitt , Marquez Jaqueline , Chen Brandon K. , Kim Daniel M. , Cheng Michael L. , Liu Eric V. , Yang Hai , Zhang Li , Sinha Meenal , Cheung Alexander , Kwek Serena S. , Chow Eric D. , Bridge Mark , Aggarwal Rahul R. , Friedlander Terence W. , Small Eric J. , Anderson Mark , Fong Lawrence
Published: April 2024

Supplementary Table 3: primer sequences
Supplementary Figure 13 from Induction of Viral Mimicry Upon Loss of DHX9 and ADAR1 in Breast Cancer Cells
Authors: Cottrell Kyle A. , Ryu Sua , Pierce Jackson R. , Soto Torres Luisangely , Bohlin Holly E. , Schab Angela M. , Weber Jason D.
Published: April 2024

Supplementary Figure 13
Supplementary Figure 11 from Induction of Viral Mimicry Upon Loss of DHX9 and ADAR1 in Breast Cancer Cells
Authors: Cottrell Kyle A. , Ryu Sua , Pierce Jackson R. , Soto Torres Luisangely , Bohlin Holly E. , Schab Angela M. , Weber Jason D.
Published: April 2024

Supplementary Figure 11
Source Data Figures from Induction of Viral Mimicry Upon Loss of DHX9 and ADAR1 in Breast Cancer Cells
Authors: Cottrell Kyle A. , Ryu Sua , Pierce Jackson R. , Soto Torres Luisangely , Bohlin Holly E. , Schab Angela M. , Weber Jason D.
Published: April 2024

Source Data Figures
FIGURE 8 from Induction of Viral Mimicry Upon Loss of DHX9 and ADAR1 in Breast Cancer Cells
Authors: Cottrell Kyle A. , Ryu Sua , Pierce Jackson R. , Soto Torres Luisangely , Bohlin Holly E. , Schab Angela M. , Weber Jason D.
Published: April 2024

Rescue of PKR activation by ADAR1-p110 and ADAR-p150. A, Representative immunoblot showing the phenotype of ADAR1 and DHX9 knockdown with ADAR1-p110 or ADAR1-p150 overexpression in SK-BR-3. Immunoblots for other replicates and uncropped blots can be found in Source Data Figures. B, Fold change of PKR phosphorylation at Thr-446 upon ADAR1 and DHX9 knockdown with ADAR1 isoform overexpression, quantified from immunoblots in A. C, Representative foci formation phenotype of ADAR1 and DHX9 knockdown ADAR1 isoform overexpression. Quantification of relative foci area is shown in D. Quantification of protein expression for other proteins of interest can be found in Supplementary Fig. S11A–S11F. Timepoints for collecting protein lysates and foci formation are the same as described in Fig. 4 for SK-BR-3. Bars represent the average of at least three replicates, error bars are ± SD. ***, P < 0.001. P values determined by Dunnett test.
FIGURE 4 from Induction of Viral Mimicry Upon Loss of DHX9 and ADAR1 in Breast Cancer Cells
Authors: Cottrell Kyle A. , Ryu Sua , Pierce Jackson R. , Soto Torres Luisangely , Bohlin Holly E. , Schab Angela M. , Weber Jason D.
Published: April 2024

DHX9 and ADAR1 redundantly suppress dsRNA sensing in ADAR1-independent cell lines. Representative immunoblot showing the phenotype of ADAR1 and/or DHX9 knockdown in MCF-7 (A), or SK-BR-3 (F). Immunoblots for other replicates and uncropped blots can be found in Source Data Figures. Protein abundance from the immunoblot in A and F was normalized by total protein abundance by quantification of the Stain-Free gel in B and G, respectively. Fold change of PKR phosphorylation at Thr-446 in MCF-7 (C) or SK-BR-3 (H) as determined by the immunoblots in A or F, respectively. Quantification of protein expression for other proteins of interest can be found in Supplementary Fig. S5A–S5L. Protein lysates were collected from cells five (MCF-7) or four (SK-BR-3) days after transduction with lentivirus encoding the shRNAs listed. Representative foci formation phenotype of ADAR1 and/or DHX9 knockdown in MCF-7 (D) or SK-BR-3 (I), quantification of relative foci area is shown in E or J, respectively. Cells were plated for foci formation 2 days after transduction and foci were stained when visible, 21 (MCF-7) or 10 (SK-BR-3) days later. K, Analysis of rRNA integrity upon knockdown of ADAR1 and/or DHX9 in MCF-7 or SK-BR-3. RNA was isolated from cells at the same time protein lysates were collected. In addition, K shows the effect of poly(I:C) [p(I:C)] transfection on rRNA integrity in MCF-7. Arrows indicate canonical RNase L cleavage products (64). Bars represent the average of at least three replicates, error bars are ± SD. *, P < 0.05; **, P < 0.01; ***, P < 0.001. P values determined by one-way ANOVA with post hoc Tukey. Comparisons between the two different shRNAs targeting DHX9 (shDHX9-3 and shDHX9-5) were not included for clarity.
Long-Term Efficacy and Safety of Enzalutamide Monotherapy in Elderly Patients with Metastatic Castration-Resistant Prostate Cancer: A Case Report
Authors: Pokrivcak Tomas , Navratil Jiri , Poprach Alexandr , Stanik Michal , Kiss Igor
Published: April 2024

Introduction: Prostate cancer is one of the most common cancers in men. Despite the sharp rise in incidence, mortality is decreasing. ARTA preparations are preferred options for asymptomatic or mildly symptomatic patients with mCRPC. The use of enzalutamide in elderly patients with mCRPC is risky and depends on a number of factors. An increased risk of falls and fractures has been shown. Case Presentation: We present a case report of an elderly patient with mCRPC treated with enzalutamide with very good long-term tolerance and efficacy. Conclusion: Despite the older age, no reduction of therapy was necessary in the patient due to good tolerance. Administration of enzalutamide in full doses resulted in a very good effect of therapy.
The Alembic, The Pen… And The Spacecraft. De la Follie’s Le philosophe sans prétention (1775): An Early Sci-Fi Novel in Lieu of a Successful Scientific Lecture?
Authors:   Mykolas Romeris University, Parent Arnaud
Published: April 2024

Louis-Guillaume de la Follie’s novel Le philosophe sans prétention, ou l’homme rare (The philosopher without pretension, or the rare man, 1775) is remembered for including the first interplanetary travel on a spaceship powered by electricity. The story, a philosophical tale typical of the Age of Enlightenment, is used by the author to convey his scientific views and popularise scientific issues. Hence, de la Follie’s work sheds light on the dissemination of scientific knowledge within French society in the second half of the eighteenth century. The article aims to show how Le philosophe serves as a bridge between the Enlightenment philosophical fiction and science fiction to determine to which extent could literature be a vehicle for disseminating scientific ideas. The study aims to be a useful contribution to a deeper knowledge of eighteenth-century provincial French scientific milieu and its links with literature. The article encompasses the introduction of the author, his work, and its reception, its examination as a conte philosophique, an early science-fiction novel, and the discussion.
A NEW TYPE OF WARFARE: Chemical Filling Facilities in Istanbul, 1914–1918
Authors: Sabancı Zeynep , Şimşeker Somer Alp ,   Boğaziçi Üniversitesi
Published: April 2024

In the total war era, states committed their scientific research to rapidly changing warfare conditions, making the management of war the primary goal of contemporary states. The weakness of primary weapons in neutralising the enemy (or enemies) was obvious from the beginning of the First World War. Constantly changing war strategies, integration of civilians into warfare, and the growing sense of impotence as the war proceeded longer than expected, prompted a return to the components of violence. Although research into the use of different chemicals, gases, and suffocating substances in weapons was not something new, its successful employment climaxed during the First World War. This study provides an analysis of the employment of chemical weapons during the First World War and revisits the scarce arguments on whether the Ottomans had taken part in producing chemical weapons. The primary focus here is the gasfilling facilities established in Istanbul under the supervision of German efforts for military purposes. Additionally, the unanticipated extraordinary effects of the use of chemical weapons, the strategies employed to cause attrition in trenches, and its effects on the Ottoman army are within the scope of this article.
DEVELOPING AUTONOMOUS ROBOTIC TRANSPORT SYSTEMS for Hospitals and Medical Facilities: Legal Challenges
Authors:   Tallinn University of Technology, Kerikmäe Tanel , Kajander Aleksi Oskar Johannes ,   Tallinn University of Technology, Hamuľák Ondrej , Mesarčík Matúš ,   Comenius University, Liiv Innar ,   Tallinn University of Technology
Published: April 2024

The article discusses the development of autonomous robotic transport systems for use in hospitals and medical facilities and presents a legal analysis with a particular focus on the development of related case-law and legislation in the past years. The new solutions are part of the evolutionary trends and hold the potential to determine the future of medical facilities. The article focuses on the search for innovative solutions that are supposed to change the quality of operation of medical premises. An internal autonomous medical transport vehicle (IAMTV) is designed for use within hospital premises and not intended for operation on public roads, thus, the scope of this analysis forgoes traffic-related aspects. Furthermore, the purpose of the vehicle is the transportation of items within its locked storage space. While the items transported may vary during use, this legal analysis presumes and focuses on the transport of medicines, medical samples, and even documents. Also, throughout the analysis, the immediate operational environment of IAMTVs will be evaluated. An assumption is made that IAMTVs are not able to operate entirely independently, in a vacuum, but rather will form a part of hospitals’ internet of things network.
Las prácticas de responsabilidad social. Un espacio para la innovación
Authors: Ospina Diego León
Published: April 2024

El presente artículo aborda una serie de reflexiones, tendientes a mostrar desde la corporación Universitaria Minuto de Dios UNIMINUTO Sede Bello, cómo el ejercicio formativo de las Practicas de Responsabilidad social, desarrollado bajo el modelo educativo Institucional, permite un acercamiento de los estudiantes a comunidades vulnerables. De esta manera, se apunta a proponer y participar en procesos de desarrollo local, donde la innovación social puede emerger como un vehículo para dicha transformación.
Una reflexión de la vivencia de un maestro, desde el concepto de resignificación, a partir de la apropiación del microrrelato como técnica de investigación
Authors: Cárdenas Ruiz Jairo Andrés
Published: April 2024

La reflexión que surge, en el ejercicio de lectura de un microrrelato, utilizado como técnica de investigación en el proyecto “La subjetividad política del maestro en diferentes espacios de aparición”, en el cual se expone, la vivencia de resignificación de un maestro. En un primer apartado, se presenta la posición que socialmente es atribuida a los maestros; donde a partir del microrrelato permite un acercamiento a la narración de sí mismo, un contarse a partir de las experiencias; en la misma línea se presenta el concepto de la resignificación, como base psicoterapéutica en la escucha de historias. En un segundo momento se retoman fragmentos del microrrelato, buscando no solamente exponer la cotidianidad y la experiencia personal del maestro, sino identificar algunos aspectos que generen una conexión de resignificación.
La construcción de argumentos multimodales digitales en la básica primaria
Authors: Calle Álvarez Gerzon Yair , Pérez Guzmán José Alirio
Published: April 2024

La construcción de argumentos multimodales digitales implica el desarrollo de habilidades cognitivas y la confluencia de diversos modos de comunicación propios de estos tipos de textos. Este artículo es el resultado de una investigación que incluyó en sus objetivos caracterizar las habilidades del pensamiento crítico asociadas a la producción de textos multimodales bajo la incidencia de un ambiente de aprendizaje apoyado por Tecnologías de la Información y la Comunicación, tic, en estudiantes de básica primaria. Aquí se presentan los resultados de la habilidad de construcción de argumentos durante la producción de textos multimodales digitales. El enfoque asumido en el estudio fue cualitativo, participaron 29 estudiantes de grado quinto, quienes durante 16 sesiones elaboraron producciones escritas digitales que pudieran evidenciar procesos de argumentación. Los principales resultados mostraron que en la básica primaria la búsqueda de información que realizan los estudiantes en la web aporta a la toma de decisión en los procesos de escritura de argumentos.
Representaciones, saberes y prácticas de profesionales del trabajo social frente a la atención y garantía de los derechos de las comunidades negras en Bogotá
Authors: Cardozo Castiblanco Aleida Carolina , Blanco Galindo Daniela , Chinchilla Romero Diana Milena , Suárez González Samantha
Published: April 2024

Analizar las representaciones, saberes y prácticas de las y los trabajadores sociales que atienden población afro implica una lectura crítica y reflexiva sobre el quehacer profesional. Se debe abordar una visión integral, que considere los conocimientos académicos, prácticas en entornos profesionales y cotidianos, retos, errores y aciertos de las labores de este gremio. Esto, teniendo en cuenta que el trabajo social como disciplina garante de derechos aporta a la materialización de los objetivos insertos en los planes, programas y proyectos focalizados en la comunidad afro, privilegiando sus intereses y necesidades. Así, la intención del grupo investigador desde este artículo es generar un escenario de reflexión para que, quienes ejercen trabajo social, valoren constantemente su accionar desde los principios éticos, su legitimidad y la intervenciones adecuadas e incongruentes que se han propuesto en el trabajo con comunidad afrodescendiente desde la apropiación del enfoque deferencial y el enfoque de Derechos Humanos.
Dinámica Familiar y Concepciones de Paz y Convivencia: Influencia en los Procesos Relacionales en la Escuela
Authors: Alba Yenny , Álvarez Aura , Daza Pacheco Adriana , Ospina Alvarado María Camila Camila
Published: April 2024

La investigación en la que se basa el presente artículo buscó comprender cómo las concepciones sobre la paz y la convivencia de las y los estudiantes de grado sexto y séptimo con dificultades relacionales y de sus familias influyen en los procesos de la escuela también de tipo relacional; asimismo, se buscó propiciar procesos de convivencia pacífica. Para ello, se identificaron categorías preliminares y emergentes como familia, habilidades personales y sociales, comunicación, convivencia pacífica y escuela, abordadas desde la perspectiva sistémica y el construccionismo social. Se involucraron algunos estudiantes y sus familias quienes participaron en talleres y entrevistas semiestructuradas. La investigación fue de corte cualitativo desde el estudio de caso con análisis categorial de narrativas. Los resultados permitieron comprender el rol de la familia como posibilitadora del desarrollo de las capacidades de los hijos e hijas y su influencia en la construcción de sus subjetividades. Asimismo, se logró identificar el papel de la comunicación desde el lenguaje generativo para crear realidades, escuchar las múltiples voces y transformar el conflicto en oportunidades para la construcción de paz y convivencia desde prácticas cotidianas en la familia y la escuela.
Educación Superior en Chile: una visión sistémica
Authors: Barrientos Oradini Nicolás , Araya Castillo Luis
Published: April 2024

Chile ha vivido un fuerte cambio en la educación superior a partir de 1980. Dos fuertes reformas han marcado este proceso y han implicado el aumento de instituciones, programas, especializaciones y matrícula. Esto ha provocado que el escenario cambie, por cuanto no solo aumentó la matricula, sino que también la conformación de la misma, principalmente en el ingreso de estudiantes más vulnerables. Frente a esto es necesario analizar temas de género, calidad, duración y costos, debido a las desigualdades que podrían evidenciarse. El aumento de la participación laboral de las mujeres, mejoramiento de las habilidades e ingresos de grupos socioeconómicos vulnerables y el mejoramiento de niveles de desarrollo tecnológico mediante el capital humano, son elementos fundamentales para el desarrollo de Chile. Dado esto, la presente investigación busca analizar el modelo en profundidad. La data muestra diferencias asociadas a contextos socioeconómicos vulnerables y posibles diferencias en la tasa de término de los programas entre hombres y mujeres. Las diferencias evidenciadas generan la necesidad de aumentar la supervisión y fiscalización en el sistema, más aún si la evidencia internacional muestra un incremento de capital humano y los datos evidencian una posible falencia o desperdicio, en dicho sentido.
Lendo Projetos: uma experimentação paradidática com Jorge O. Caron
Authors: Gambarato Roberto Rampazzo
Published: April 2024

Jorge O. Caron – lendoprojetos (1995) é uma apostila paradidática desenvolvida a partir da transcrição de aulas e acrescida de textos do professor Caron. Foi produto de meu trabalho de monitoria junto às disciplinas práticas de atelier por ele ministradas no primeiro semestre de 1994. Seu processo de concepção e produção é o objeto deste relato contextualizado, ainda, a um período seminal de consolidação do curso de graduação em Arquitetura e Urbanismo da Escola de Engenharia de São Carlos (atual IAU-USP). A partir da editoração não publicada do original da apostila, um excerto fac-similar do texto sobre a Torre da TV Cultura apresenta-se, agora, nesta edição especial da Revista Risco dedicada ao mestre. Concomitantemente, derivamos desta experiência reflexões e interpretações acerca de seu conteúdo específico, bem como, do legado de Caron em nossa formação como arquitetos e urbanistas.
Espaços de ensino: projetos de Jorge O. Caron
Authors: Ruggiero Amanda Saba , Andrade Carlos Roberto Monteiro de
Published: April 2024

Sem resumo.
Matriz baseada em competências para a Residência de Medicina Física e Reabilitação
Authors: Suzigan Erika Magalhães , Kim Stella , Rocha Eduardo Melo Carvalho , Murgo Camélia Santina
Published: April 2024

As matrizes por competências foram preconizadas pela Comissão Nacional de Residência Médica (CNRM) para que todas as Sociedades Médicas reestruturassem seus programas de residência médica e aprimoramento ao determinar os objetivos de aprendizagem em cada ano da especialização.
Representation of Indian Christians and their ‘othering’ in Mainstream Indian Cinema, a Critical Evaluation
Authors: Belladi Sunil , John Hannah Sarasu
Published: April 2024

The recent changing tides of social and political climate across the globe has impacted the influence of media and culture (Michael Gurevitch, 1982), and in effect, the social fabric of our globalised society. This paper uses theories from Sturcturalism to understand better the larger socio-cultural structures that lay deeply embedded into our understanding of society as a whole. This cultural understanding is important to look at media (and by extension film) through its power dynamics and capital it provides to the groups that it represents and the groups that it does not. The study of these representations as being in opposition to each other in the way of ‘in’ and ‘out’ groups to understand the ways in which culture and cinema receive minorities, and for this paper, the Indian Christian identity in India. Mainstream cinema or Bollywood helps in the translation of in and out groups into the ‘othering’ of religious minorities (Brons, 2015) while also presenting and confirming the already existing ideas of the identity of minorities. This paper looks to identify the importance of alternative cinema, in this case regional Malayalam Cinema, for minorities that have been marginalised by the media and their role in the repairing the self-image of these minorities. The intrinsic binary between the alternative and mainstream cinema here are representative of the power and lack thereof for these minorities in terms of their social and self-perception. This paper goes a step further by not just looking at Indian Christians as a homogeneous whole but also determining the difference in portrayal and representation of the different denominations of the Indian Christian community. Therefore, this paper attempts to explain the reasons for the invisibility of Indian Christian representation or its ‘other-ing’ in mainstream film while also understanding the binary in the internal cultural dynamics within the Christian population through the lens of popular culture and regional or alternative cinema.
Spatial Imagination, Embedded Female Agency, and Women’s Networks in Early Christianity
Authors: Maier Harry O.
Published: April 2024

Using spatial and intersectional analysis as well as theory dedicated to embedded gender agency, this article argues that the religious identities of female Christians were dynamic and pluriform not static and singular. These tools help to identify the ways in which one or more aspects of simultaneously co-existing female gendered identities became salient in different situations, through specific social practices. Documents for analysis include references to urban women in Pauline literature with special attention to widows/single women in 1 Timothy, ascetical women rejecting marriage as represented by the apocryphal Acts of Paul and Thecla, and the representations of female Christ followers and the gendering of Christianity by first and second century Greek and Roman polemicists/magistrates against Christ religion (Celsus, Lucian, Caecilius, Pliny).
Women’s Agency in the Cults of the Greco-Egyptian Deities in Hellenistic Athens
Authors: Neumann Sabine
Published: April 2024

Cults for Greco-Egyptian gods such as Isis, Sarapis, Anubis, and Harpocrates enjoyed great interest in the Greek world of the Hellenistic period. This article analyses the agency of women in these cults in Hellenistic Athens and Delos. It poses the question whether the agency of women can be directly compared to the agency of men. It identifies, first, reservations in modern scholarship about women in positions of religious power, and, second, institutional boundaries that excluded women from official priestly positions. It demonstrates the ways in which women nonetheless held agency within family networks, and, third, possessed ritual competencies beyond formal offices and a relationship to deities on a personal level.
Commanding the Queen
Authors: Brownsmith Esther
Published: April 2024

The gendered lines between direct and indirect agency blur in the book of Esther, in line with its ‘topsy-turvy’ carnivalesque attitude. Queen Esther acts with direct agency (the power to command her fellow Jews, then accusing Haman of treachery), while her cousin Mordecai gains power indirectly (through his relationship with Esther and through the knowledge he gains from listening to eunuchs) and is threatened with death when he attempts to exercise more direct agency. These reversals of expectations can be connected with the Bem Sex Role Inventory (BSRI), an influential twentieth century set of descriptors that link certain psychological traits to masculinity or femininity—with most of the words associated with direct agency in the ‘masculine’ category. One could simply conclude that the Book of Esther is blurring gender lines, but an intersectional perspective reveals more at stake: the Book of Esther demonstrates that the power dynamics that dictate who can have direct agency do not always align with gender. This forces us to re-examine metrics like the BSRI for how they reflect existing power roles rather than inherent tendencies. Is direct agency inherently masculine, or just something that men have had more capacity to exercise? The complicated dynamics of the Book of Esther bring this question into focus, without offering a clear-cut answer.