bluuebunny/crossref_metadata_2025 huggingface dataset:
Taxonomical study on a sample of pulmonates from Santa Maria da Vitória, Bahia, Brazil, with description of a new genus and four new species (Mollusca: Orthalicidae and Megalobulimidae)
Authors: Simone Luiz Ricardo L.
Published: February 2019

A sample of Pulmonata collected in Santa Maria da Vitória, interior of Bahia, Brazil, in Caatinga semi-arid environment, is studied taxonomically. From the five species, four are revealed as new, including a new genus. The new taxa are the Bulimulidae (1) Kora corallina gen. et sp. n. characterized by the elongated shell with aperture somewhat dislocated from the shell axis, and an oblique tooth in middle level of inner lip; (2) Spixia coltrorum, mainly characterized by an uneven spire, delicate sculpture and peristome with 4 equidistant teeth; (3) Anostoma tessa, mainly characterized by a broad spire and well-developed anal canal; and the Megalobulimidae (4) Megalobulimus amandus, mainly characterized by pointed protoconch sculptured by dense quantity of axial cords. Rhinus suturalis is the only previously known species, but its geographic distribution is expanded southwards to Bahia state. A discussion with respect to necessity for improving the study on the malacofauna from the interior region of the Brazilian Northeast and the importance for preservation of the Caatinga biome is also provided.
Contribuição para o estudo dos Rhinotragini (Coleoptera, Cerambycidae). VI. Ecliptoides Tavakilian & Peñaherrera-Leiva, 2005
Authors: Martins Ubirajara R. , Santos-Silva Antonio , Clarke Robin O.S.
Published: February 2019

O gênero Ecliptoides Tavakilian & Peñaherrera-Leiva, 2005, recentemente revisto por Clarke (2009), é revisado novamente, principalmente devido à necessidade de transferência de espécies de Eclipta Bates, 1873, e Odontocera Audinet-Serville, 1833 para este gênero. Três novas espécies são descritas do Brasil: E. schmidi, E. tavakiliani, e E. hogani. Ommata eunomia var. rufula Melzer, 1934, e Ommata (Eclipta) plaumanni Fuchs, 1961 são revalidadas e consideradas espécies de Ecliptoides. Espécies transferidas de Eclipta para Ecliptoides: E. bivitticollis (Fisher, 1952); E. eunomia (Newman, 1841); E. pilosipes (Peñaherrera-Leiva & Tavakilian, 2004); E. fanchonae (Tavakilian & Peñaherrera-Leiva, 2003); E. giuglarisi (Peñaherrera-Leiva & Tavakilian, 2004); E. vasconezi (Peñaherrera-Leiva & Tavakilian, 2004); E. vicina (Melzer, 1927); E. lauraceae (Peñaherrera-Leiva & Tavakilian, 2004); e E. bauhiniae (Peñaherrera-Leiva & Tavakilian, 2004). Espécies transferidas de Odontocera para Ecliptoides: O. quadrivittata Melzer, 1922; O. pusilla Gounelle, 1911; e O. monostigma (Bates, 1869). Novo sinônimo: Ommata (Eclipta) collarti Fuchs, 1959 = Odontocera pusilla Gounelle, 1911 (= Ecliptoides pusillus). Lectótipos são designados para Ommata (Eclipta) vicina e Ommata (Eclipta) collarti. Novos registros de distribuição são fornecidos para E. eunomia, E. pilosipes, E. plaumanni e E. fanchonae. É fornecida chave para as espécies de Ecliptoides.
Contribuição para o estudo dos Rhinotragini (Coleoptera, Cerambycidae).VII. O gênero Ischasioides
Authors: Martins Ubirajara R. , Santos-Silva Antonio , Clarke Robin O.S.
Published: February 2019

Eclipta brasiliensis (Fisher, 1947) é transferida para Ischasioides Tavakilian & Peñaherrera-Leiva, 2003 e sinonimizada com I. crassitarsis (Gounelle, 1911). Ischasia m. atrocephala Fuchs, 1956 e Ischasia m. nigrovittata Fuchs, 1956, embora sem status em nomenclatura, são confirmadas como sendo igual a I. crassitarsis. Ischasioides berkovae sp. nov. é descrita do Brasil. É fornecida uma chave para as espécies de Ischasioides.
Feasibility Assessment of Using the Complete Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) Item Library
Authors: Shepshelovich Daniel , McDonald Kate , Spreafico Anna , Razak Albiruni R.A. , Bedard Philippe L. , Siu Lillian L. , Minasian Lori , Hansen Aaron R.
Published: February 2019

The patient-reported outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) complements capture of symptomatic adverse events (AEs) by clinicians. Previous trials have typically used a limited subset of relevant symptomatic AEs to reduce patient burden. We aimed to determine the feasibility of administering all 80 AEs included in the PRO-CTCAE library by approaching consecutive patients enrolled in a large academic phase I program at three points in time. Here, we report a preplanned analysis after enrolling the first 20 patients. All items were answered on 51 of 56 potential visits (adherence 91%). Three (5%) additional PRO-CTCAE assessments were partially completed, and two (4%) were missed because of conflicting appointments. No patient withdrew consent or chose not to complete the assessments once enrolled on study. Future trials of experimental drugs that incorporate the PRO-CTCAE should consider using this unselected approach to identify adverse events more completely.
Evaluating the Strength of the Association Between Industry Payments and Prescribing Practices in Oncology
Authors: Mitchell Aaron P. , Winn Aaron N. , Lund Jennifer L. , Dusetzina Stacie B.
Published: February 2019

Background

Financial relationships between physicians and the pharmaceutical industry are common, but factors that may determine whether such relationships result in physician practice changes are unknown.

Materials and Methods

We evaluated physician use of orally administered cancer drugs for four cancers: prostate (abiraterone, enzalutamide), renal cell (axitinib, everolimus, pazopanib, sorafenib, sunitinib), lung (afatinib, erlotinib), and chronic myeloid leukemia (CML; dasatinib, imatinib, nilotinib). Separate physician cohorts were defined for each cancer type by prescribing history. The primary exposure was the number of calendar years during 2013–2015 in which a physician received payments from the manufacturer of one of the studied drugs; the outcome was relative prescribing of that drug in 2015, compared with the other drugs for that cancer. We evaluated whether practice setting at a National Cancer Institute (NCI)-designated Comprehensive Cancer Center, receipt of payments for purposes other than education or research (compensation payments), maximum annual dollar value received, and institutional conflict-of-interest policies were associated with the strength of the payment-prescribing association. We used modified Poisson regression to control confounding by other physician characteristics.

Results

Physicians who received payments for a drug in all 3 years had increased prescribing of that drug (compared with 0 years), for renal cell (relative risk [RR] 1.81, 95% confidence interval [CI] 1.58–2.07), CML (RR 1.22, 95% CI 1.08–1.39), and lung (RR 1.69, 95% CI 1.58–1.82), but not prostate (RR 0.97, 95% CI 0.93–1.02). Physicians who received compensation payments or >$100 annually had increased prescribing compared with those who did not, but NCI setting and institutional conflict-of-interest policies were not consistently associated with the direction of prescribing change.

Conclusion

The association between industry payments and cancer drug prescribing was greatest among physicians who received payments consistently (within each calendar year). Receipt of payments for compensation purposes, such as for consulting or travel, and higher dollar value of payments were also associated with increased prescribing.
Power-law correlations of mine subsidence for a metal mine in China
Authors: Hui Xin , Ma Fengshan , Guo Jie , Xu Jiamo
Published: February 2019

Great damage has been done to the earth’s surface as a result of mining. An important concern is whether power-law occurrence rate–scale statistics that are used to study many natural hazards, such as landslides and volcanic eruptions, can be used to study mine subsidence. The ground subsidence in Longshou Mine, China, is analysed using data from a 12·5-year-long (May 2003–November 2015) continuous field investigation with 488 global positioning system monitoring points. The results of occurrence rate–scale statistical analysis fit well with a power-law relationship – that is, M (S) ∼ S −β . The subsidence power-law parameter varies between 1·06 and 2·18 for settlement between 2 and 257 mm. Additionally, the uplift parameter varies between 1·01 and 2·45 for uplift between 1 and 123 mm, regardless of changes in the goaf geometry and rock mass integrity. The power-law model of the results of the occurrence rate–scale statistical analysis is established, and the underlying controls of the power laws, the self-organised criticality of the subsidence system and the application of power laws are discussed. The spatial self-similarity and long-range spatial correlations of mine subsidence are expressed by significant power-law dependencies, which suggests that both large- and small-scale mine subsidence may follow the same physical and mechanical principles.
Full-scale test for KBS-3H spent nuclear fuel repository alternative in Sweden
Authors: Pintado Xavier , Schatz Timothy , García-Siñeriz José Luis , Kronberg Magnus
Published: February 2019

This paper describes the instrumentation of a full-scale test, known as the Multi-Purpose Test, of the KBS-3H spent nuclear fuel design alternative carried out in the Äspö Hard Rock Laboratory (Sweden). This test is part of the Large Underground Concept Experiments EU project, where Posiva and Svensk Kärnbränslehantering are partners. The test consists of two aspects. The first is that of a ‘demo’ test whose aim is to check the manufacturing and installation process of the different components of the KBS-3H design. The second is the instrumentation and monitoring of the test system. The test is carried out under isothermal conditions and the scope was to measure component displacements, the hydration and swelling pressure of the bentonite material and the water pressure in host rock.
E. Coli Optical Quantification v1
Authors: Schackart Kenneth , Kaarj Kattika
Published: February 2019

This procedure details how to culture E. Coli K-12 in suspension and quantify cultured bacteria using a spectrometer.
Traditional Chinese Medicine for Helicobacter Pylori infection: An Evidence Assessment for Systemic Reviews and Meta-analysesl v3
Authors: Si Xiao-bei , Wang Shuai , Zhang Xu-min , Lan Yu
Published: February 2019

Background: In recent years, many studies reported the anti-Hp effects of Traditional Chinese Medicine. Based on these studies, there had been many relevant systemic reviews and meta analyses with variable results Aim: This overview aims to investigate the general characteristics and assess the methodological quality of these systemic reviews/meta ana lyses (SR/MAs). Method: In this overview, we intend to includ systemic reviews/meta analyses with comparison of Chinese medicine and western medicine on helicobacter pylori infection by searching databases of Medline, Embase, Web of Science, China National Knowledge Infrastructure Database (CNKI), Chinese VIP Information (VIP), Chinese Medical Databases (CMB) and Wan-Fang Database until December 16th, 2018. AMSTAR and PRISMA tools will be adopted to assess the methodological quality and reporting characteristics respectively. Conclusion: The methodological quality of these SR/MAs will be assessed as clinical evidence and our result may help further use of them.
Türkiye’de Sporcuların Cinsel Taciz Algıları ve Deneyimleri
Authors: ÖZEN Gülay , EMİR Esra , KOCA Canan
Published: February 2019

Bu makalenin amacı, kadın ve erkek sporcularıncinsel taciz algılarını ve deneyimlerini araştırmaktır.Araştırmaya farklı spor branşlarından 194kadın ve 178 erkek sporcu katılmıştır. Araştırma verileri,cinsel taciz davranışı konusundaki farkındalıklarını,cinsel tacize maruz kalma durumlarını ve cinseltaciz önlemlerine yönelik görüşleri içeren sorulardanoluşan, araştırmacılar tarafından geliştirilen bir anketyoluyla toplanmıştır. Veriler betimleyici istatistikiyöntemler ve ki-kare ile analiz edilmiştir. Analiz sonuçlarınagöre; kadın sporcuların cinsel taciz davranışıolarak tanımladıkları davranışların ilk sıralarındacinsel yaşam hakkında sorular sorulması (%76),vücudu ile ilgili cinsiyetçi şakalar (%66), övgü ya dayorum yapılması (%71) yer almıştır. Erkek sporcularise; cinsel içerikli materyaller gösterilmesini (%70),tekrarlanan istenmeyen flört tekliflerini (%51) vemüstehcen bakışları (%72) cinsel taciz davranışlarıolarak algıladıklarını belirtmişlerdir. Erkek sporcuların%27’si soyunma odalarında cinsel tacize maruzkaldıklarını belirtirken, kadın sporcuların %26,3’ü sporalanlarında cinsel tacize maruz kaldıklarını belirtmişlerdir.Kadın sporcuların %24,2’si uyararak cinsel tacizetepki gösterdiklerini, %24’ü tepki göstermediklerini ifadeederken, erkek sporcuların %27’si cinsel tacizi şakagibi algılayıp yok saydıklarını, %11,2’si fiziksel tepki gösterdikleriniifade etmişlerdir. Çalışmanın bulguları genelolarak Türkiye’de kadın ve erkek sporcuların cinseltaciz deneyimleri olduğunu ortaya koymaktadır.
Unpacking Attitudes on Immigrants and Refugees: A Focus on Household Composition and News Media Consumption
Authors: De Coninck David , Matthijs Koen , Debrael Marlies , De Cock Rozane , D'Haenens Leen
Published: February 2019

This study examines how household composition and news media consumption and trust are related to attitudes towards two minority groups—immigrants and refugees—in a representative sample of the adult population (n = 6000) in Belgium, Sweden, France, and the Netherlands. We find that Swedes hold the most positive attitudes towards both groups, while the French are found to be most negative. The Belgians and Dutch hold moderate attitudes. There is also evidence that attitudes on refugees are more negative than attitudes on immigrants in Sweden and France, but not in Belgium and the Netherlands. Using structural equation modeling, we find that household composition is not directly related to attitudes, but indirect effects through socio-economic status and media consumption indicate that singles hold more negative attitudes than couples. Public television consumption, popular online news consumption, and trust in media are positively related to attitudes, whereas commercial television consumption is negatively associated with them.
We Live Here, and We Are Queer!: Young Gay Connected Migrants’ Transnational Ties and Integration in the Netherlands
Authors: Patterson Jeffrey , Leurs Koen
Published: February 2019

Upon arrival to Europe, young migrants are found grappling with new language demands, cultural expectations, values, and beliefs that may differ from global youth culture and their country of origin. This process of coming-of-age while on-the-move is increasingly digitally mediated. Young migrants are “connected migrants”, using smart phones and social media to maintain bonding ties with their home country while establishing new bridging relationships with peers in their country of arrival (Diminescu, 2008). Drawing on the feminist perspective of intersectionality which alerts us socio-cultural categories like age, race, nationality, migration status, gender and sexuality impact upon identification and subordination, we contend it is problematic to homogenize these experiences to all gay young adult migrants. The realities of settlement and integration starkly differ between desired migrants – such as elite expatriates and heterosexuals – and those living on the margins of Europe – forced migrants and lesbian, gay, trans, queer and intersex (LGBTQI) migrants. Drawing on 11 in-depth interviews conducted in Amsterdam, the Netherlands with gay young adult forced and voluntary migrants, this paper aims to understand how sexual identification in tandem with bonding and bridging social capital diverge and converge between the two groups all while considering the interplay between their online and offline entanglements of their worlds.
TRANSFORMATION OF CONCEPT "COMPETITION" IN SCIENTIFIC THOUGHT IN THE CONTEXT OF PUBLIC DEVELOPMENT
Authors: Zubchyk O.
Published: February 2019

The purpose of the article is to reveal the content of the transformation of the concept of "competition", which synthesizes and reflects the objective reality, showing heuristic potential in the context of public policy research and public administration. The author showed that the evolution of conceptual views on competition is evidenced by the transformation of the concept of "competition" and related concepts (subject, object of competition, economic relations, and state economic policy). The influence of various factors on the conceptualization of experience at different levels (personal, state-public relations, interstate) is substantiated. The author considered the transformation of the concept of "competition" in scientific thought in the context of social development from the era of antiquity to our day. The author proposed a methodology that allows deeper analysis of the role of subjects of socio-political and statemanagement relations in the context of the study of state policy and public administration. The research on the transformation of the concept of "competition" in the context of social development in the most common and influential theories provides additional opportunities for analyzing the role of socio-political and state-managerial relations in the context of studying public policy as a mechanism of public administration .
DETERMINANTS OF THE TRANSFORMATION OF PUBLIC SERVICE CONCEPTS IN THE COUNTRIES OF THE EUROPEAN UNION
Authors: Syvyi R.
Published: February 2019

The purpose of the article is to identify the concepts of the functioning of public service systems based on the generalization of the institutional environment for the transformation of the concepts of public service in the countries of the European Union. The institutional conditions for the transformation of the civil service in the EU countries are revealed. It is proved that under the new conditions there is an urgent need to identify the institutional prerequisites and factors of the transformation of the civil service in the context of European integration in order to understand the vector of movement of the civil service institute in Ukraine. On the basis of the study of the modernization experience, it has been determined that even minor changes in the structure of public authorities are accompanied by negative consequences, namely, the costs of conducting liquidation or reorganization measures. The main strategies of the modernization processes carried out are outlined. It was found that the institutional preconditions for the transformation of the civil service in the EU originate from constitutional mechanisms that are deeply rooted in the cultural, social and political values that are united around the basic provisions of democracy. It is shown that the prerogatives of functional measures emphasizing the powers of civil servants are an important institutional precondition for the transformation of the civil service. The generalization of the factors of transformation of the civil service in the context of European integration provides an understanding of the vector of the movement of the civil service in Ukraine through the creation of a common European administrative space.
JUWELS: Modular Tier-0/1 Supercomputer at the Jülich Supercomputing Centre
Authors: Krause Dorian
Published: February 2019

JUWELS is a multi-petaflop modular supercomputer operated by Jülich Supercomputing Centre at Forschungszentrum Jülich as a European and national supercomputing resource for the Gauss Centre for Supercomputing. In addition, JUWELS serves the Earth system modeling community within the Helmholtz Association. The first module deployed in 2018, is a Cluster module based on the BullSequana X1000 architecture with Intel Xeon Skylake-SP processors and Mellanox EDR InfiniBand. An extension by a second Booster module is scheduled for deployment in 2020.
The Dynamics of Marital Satisfaction of the Parents of Children with Autism: A Mixed Method Study
Authors: TÜMLÜ Cem , AKDOĞAN Ramazan
Published: February 2019

Bu çalışmanın amacı otizmli çocuk ebeveynlerinin eş destek algıları ile evlilik doyumunun düzeyi, yordayıcıları ve kaynaklarını ortaya koymaktır. Bu amaç doğrultusunda nicel ve nitel verilerin kullanıldığı bir karma yöntem kullanılmıştır. Araştırmaya 0-6 yaş arasında otizmli çocuğu olan 147 ve aynı yaş aralığında normal gelişim gösteren çocuğu olan 142 ebeveyn katılmıştır. Tüm katılımcıların evlilik süreleri 2-16 yıl arasında değişmektedir. Nicel veriler Eş Destek Ölçeği ve Evlilik Yaşamı Ölçeği aracılığıyla toplanmış, verilerin analizinde çok yönlü MANOVA testi ve regresyon analizi kullanılmıştır. Nitel veriler ise 9 baba ve 12 anneden üç ayrı odak grup görüşmesi aracılığıyla toplanmış ve içerik analizi yapılmıştır. Nicel bulgular otizmli çocuk ebeveynlerinin normal gelişim gösteren çocuk ebeveynlerine göre hem eşlerinden gördükleri destek algılarının hem de evlilik doyum düzeylerinin düşük olduğunu ortaya koymuştur. İki grup eş destek algısının alt boyutları bakımından karşılaştırıldığında; otizmli çocuk ebeveynlerinin duygusal destek, takdir etme desteği ve sosyal ilgi desteği algılarının normal çocuk ebeveynlerinden düşük olduğu, iki grubun sadece maddi yardım ve bilgi desteği algısı bakımından farklılaşmadığı belirlenmiştir. Ayrıca otizmli çocuk annelerinin evlilik doyumlarının anlamlı yordayıcıları sırasıyla duygusal destek, takdir etme desteği, sosyal ilgi desteği ve maddi yardım ve bilgi desteği iken; babaların evlilik doyumunda sadece takdir etme desteği anlamlı bir yordayıcıdır. Nitel veriler araştırmacılar tarafından geliştirilen Yarı Yapılandırılmış Görüşme Formu aracılığıyla toplanmıştır. Nitel analizlerde evlilik doyumunda hem anneler hem de babalar için “çocuğun engel durumunu kabul etme” ve “partner olarak birbirine zaman ayırma”, sadece anneler için “çocuğun sorumluluğunu paylaşma”, “eşi tarafından yalnız bırakılma” ve “partner olarak duygusal paylaşımda bulunma”, sadece babalar için ise “takdir görme” ve “iletişimsel sorunlardan kaynaklı anlaşılamama” evlilik doyumunda ana temalar olarak ortaya çıkmıştır. Bulgular otizmli çocuğa sahip anne ve babalara verilecek psikolojik desteğin onlar için ön plana çıkan sorunlar temelinde yürütülmesi gerektiğini göstermektedir. Ayrıca bulgular ebeveynlerin evlilik ve eş destek algısı düzeylerinin başka hangi dinamiklerle ilgili olabileceğinin araştırılması gerektiğini düşündürmektedir. 
Need Satisfaction, Partner Attachment, and Romantic Relationship Quality: A Multiple Mediation Model
Authors: SAĞKAL Ali Serdar , ÖZDEMİR Yalçın
Published: February 2019

Research findings underscore the importance of need satisfaction on romantic relationship quality. However, there is a need for research to explore the mechanism that account for the relationship between need satisfaction and relationship quality. The present study examines direct and indirect effects of need satisfaction on romantic relationship quality through partner attachment avoidance and anxiety. Data were collected from 309 emerging adults (Mage = 20.91 years, SD = 1.96; 81.6% female) currently being in a romantic relationship. Participants completed a battery of measures assessing need satisfaction, partner attachment, and relationship quality. After removing missing values and outliers, a total of 290 cases were retained for the analyses. Consistent with self-determination theory, results indicated that need satisfaction was associated with relationship quality and that this association was partially mediated through partner attachment avoidance. Counter to expectations, partner attachment anxiety did not mediate the relationship between need satisfaction and relationship quality. Findings highlight the role of need satisfaction and partner attachment avoidance in contributing to emerging adults’ relationship quality. Limitations, implications, and future directions are discussed.
English Language Teacher Education in Turkey: Why Do We Fail and What Policy Reforms Are Needed?
Authors: ÖZTÜRK Gökhan , AYDIN Belgin
Published: February 2019

With the changing paradigms in mainstream educational sciences identifying teacher education as a relatively independent area, approaches and policies in second language teacher education have undergone significant reforms throughout the world in the last two decades. Turkey, as a country in the midst of both social and cultural changes due to stream of events around it, has also attempted for such reforms in its English Language Teacher Education (ELTE) policies since the foundation of Higher Education Council leading to a unified model of pre-service teacher education. Teacher education, however, has always been one of the highly debated and criticized issues in the country by all the stakeholders. This paper scrutinizes the current ELTE policies in both pre-service and in-service levels in Turkey. The pre-service ELTE programs and how teachers are trained after graduation are presented focusing on the weaknesses and the drawbacks of the programs addressing to the relevant literature. Finally, the necessary policy reforms at all levels of teacher education are suggested by referring to the implementations of countries with high-quality teacher education systems.
STEM Focused Professional Development Process Of Elementary School Teachers: An Action Research
Authors: BOZAN Mehmet Arif , ANAGÜN S. Şengül
Published: February 2019

Bu araştırmanın amacı, 2018 Fen öğretim programına giren STEM uygulamalarının sınıf öğretmenlerinin mesleki gelişimine etkilerinin ortaya konulmasıdır. Araştırma deseni, daha önce belirlenmiş kuramsal bir çerçeve içerisinde sınıf öğretmenlerinin STEM odaklı mesleki gelişim süreçlerine olan etkilerini incelemek amacıyla eylem araştırması olarak belirlenmiştir. Bu süreçte araştırmacı ve uygulayıcılar yoğun etkileşim içinde bulunmuşlardır. Nitel bir çalışma olan araştırmadaki verileri, bu projeye katılan Eskişehir ili Seyitgazi ilçesinde bulunan üç ilköğretim okulunda gönüllü altı sınıf öğretmeninden ve yirmi sekiz öğrenciden yarı yapılandırılmış görüşme formu, video kayıtları, araştırmacı günlüğü, öğrenci ürünlerinden elde edilmiştir. STEM uygulamaları gönüllü altı öğretmen arasından seçilen iki öğretmenin sınıflarında gerçekleştirilmiştir. Araştırmada elde edilen veriler betimsel analiz yöntemiyle çözümlenmiştir. Araştırmada toplanan verilerden STEM eğitiminin uygulanabilirliğine, sınıf öğretmenlerine verilen STEM eğitimi sürecinin nasıl gerçekleştiğine, STEM eğitiminin sınıf öğretmenlerinin mesleki gelişimlerine olan etkilerine, STEM eğitiminin öğrencilerin beceri gelişimini nasıl etkilediği yönünden bulgulara erişilmiştir. Araştırmaya katılan öğretmenlerin STEM eğitimini mesleki gelişim açısından faydalı buldukları fakat zaman, maddi yetersizlik gibi sıkıntılar yaşadıkları sonuçlarına ulaşmıştır.
Evaluation and comparison of anti-cancer activity of dapagliflozin and canagliflozin in oral cancer cell line: an in vitro study
Authors: Vinay Nenavath , David Darling Chellathai
Published: February 2019

Background: Cancer is rapidly evolving life-threatening ailment in the mankind due to changes in daily food intake and lifestyle changes. Oral carcinoma is 6th major cause of cancer death in the world and it is third major reason of cancer mortality in India. Every cell in the human body requires glucose for its metabolic energy. Besides normal cell, cancer cells also require the glucose for its endurance and multiplication. SGLT2 inhibitors which are aimed at diabetes therapy exhibited anticancer properties also in colon and pancreatic cancer lines. Present study aim is to evaluate the anticancer activity of SGLT2 inhibitors against oral cancer cell by MTT Assay.Methods: To evaluate the anticancer activity of SGLT2 inhibitors MTT Cytotoxic assay is performed as per standard protocols. Cancer cells were plated in 24-well plates and incubated at 370C with 5% CO2 condition. After convergence, samples are added to the plates in various concentrations and allowed to incubate then they are detached from the plates and cleansed with the reagents. The wells are coated with the dye and incubated. Later samples are analysed in UV-spectrophotometer.Results: Cytotoxic assay showed decrease in cell viability with increasing dose of SGLT2 inhibitors. IC50 values were determined graphically. The IC50 value of dapagliflozin is 400µg/ml and canagliflozin is 250µg/ml respectively after 24 hours of Assessment.Conclusions: The results of the current study give us an evidence that SGLT2 inhibitors dapagliflozin and canagliflozin exhibits anticancer property in Oral Cancer cell line.
Interns perception towards pharmacology during clinical postings at RIMS, Raichur, India
Authors: Gavimath Neeta T. , Chavan Vasant R. , Dixit Rohit
Published: February 2019

Background: Every medical graduate must have the intention to prescribe rationally. It is pharmacology which teaches rational of prescribing of drug in undergraduate medical course. Therefore, many eminent medical educationists believe that pharmacology is the most essential part of the medical curriculum. Medical graduates join as interns in their respective teaching hospital immediately after graduation. Although interns work is usually under the supervision of a senior consultant but there are occasions, when they need to make their own decision. Internship is the intermediate period between under-graduation and general practice. The dexterity of health professional relies upon prescribing practices. Clinical pharmacology and therapeutics (CPT) is a crucial discipline for interns to acquire safe and rational prescription of drugs. This study was conducted with the intention to provide some light about the knowledge of pharmacology among the interns in RIMS Hospital Raichur, Karnataka.Methods: The study was done on interns of RIMS, Raichur. It was a descriptive questionnaire-based prospective study. A structured questionnaire modified from the work of Oshikoya et al, was used in the study which included four major categories namely basic demographic information, undergraduate CPT teaching, experience of adverse drug reaction (ADR) and any deficiency in the under-graduate CPT teaching.Results: Out of these 107 participants 54 (42%) rated pharmacology knowledge is good, while another 53(40%) had average understanding. As high as 80% (85) intern population feel that undergraduate training has prepared them to prescribe safely. 45 (41%) interns have already observed cases of adverse drug reactions in their short active clinical life.Conclusions: The present study has identified that pharmacology and therapeutics course curriculum is not enough to produce safe prescribers.
Transthoracic endoscopic sympathectomy for upper limb hyperhidrosis
Authors: Alkatta Mohamed Abdullah , Alqatta Wail Mohamed
Published: February 2019

Background: Hyperhidrosis is a disabling troublesome characterized by excessive perspiration that produces a social and professional deficit for patients. Thorasoscopic sympathectomy represents the best approach for this disorder. There are several methods for treatment of extensive hyperhydrosis which includes: Antiperispirant, anticholenergic, ionophoresis, psychotherapy, botulinum toxins injection and surgery. Endoscopic Thorasoscopic Sympathectomy (ETS) which is most safety, which require excision and electrocoagulation by cautery or ultrasonic shear which is used in this study, and by Clips application on the thoracic sympathetic ganglia between T2 to T4 or T5. ETS is minimally invasive procedure that increased the interest in this modality of treatment.Methods: This prospective study include 78 cases admitted to IBN Sina Hospital, Sana’a, Yemen during the period of November 2013 and August 2017, 66 were male (84.6%) and, 12(15.4) are female. The procedure based on Endoscopic Thorasoscopic Sympathectomy.Results: Seventy-eight patients underwent bilateral thorasoscopic, palmer hydrosis in 55 (70.5%) patients, 14 (17.9%) combined axillary, palmar and planter and 9 (11.6%) combined with planter and axillary hyperhidrosis. Complications included partial right pneumothorax requiring chest drain one case (1.28%), chronic wound pain five to seven months two cases (2.56%) and compensatory sweating twenty -three cases (29.5%). There was one (1.25%) exploratory rethoracoscopy for bleeding at the end of the procedure which was the third intercostal artery at the vertebra-costal junction and controlled by ultrasonic shear cauterization. No cases of Horner's syndrome were identified. There was no mortality.Conclusions: Thorasoscopic sympathectomy is a safe and effective procedure for treatment of hyperhidrosis. Hospital stay is very short, lower post-operative rates of complication or infection and early wound healing. Patient more satisfied with the immediate treatment effects on the preoperative symptoms of hyperhidrosis.
Clinico epidemiological study of thermal burns in a tertiary care hospital
Authors: G. Ravikumar , P. Shanmugapriya , G. R. Sugapradha , R. Senthamilselvi
Published: February 2019

Background: Substantial number of people suffers from burn injuries every year in India that make the patients endure disease, surgeries and years of rehabilitation. The higher mortality and prolonged morbidity results in heavy social, economic and clinical burden to the nation. The objective was to study and analyse the socio-demographic profile of burn patients in addition to evaluate the causes, manner and clinical course of burn patients along with its outcome.Methods: This was a registry based retrospective study on 114 burns patients, admitted in a Tertiary Care Hospital in South India from January 2018 to June 2018. Data were collected and assimilated comprehensively.Results: The age group of patients ranged from 13-70 years, the mean age being 29 years. The overall male, female to transgender ratio was 0.57:1:0.01. Most of the patients were married (66.66%). The TBSA involvement in burns ranged from 10% to 100% and the mean TBSA was found to be 11.4±2.95. A higher TBSA involvement is associated with an increased risk of mortality and this association between TBSA and mortality was found to be statistically significant (p<0.05). Mortality ratio in this study was 51.75% and septic shock (58%) was the most common cause of death followed by hypovolemic shock (42%).Conclusions: Burns are one of the leading causes of preventable morbidity and mortality, provided the prevention strategies address the hazards of specific burn injuries, awareness education for vulnerable population and targeted first aid training.
Advantage of ultrasonography in the diagnosis of acute appendicitis at Al-Karama Teaching Hospital
Authors: Surriah Mohammed Hillu , Bakkour Amine Mohammed , Hussain Nidaa Ali Abdul
Published: February 2019

Background: The clinical diagnosis of acute appendicitis remains a challenge to surgeons. Different aids were introduced to improve the diagnostic accuracy. Among these modalities, ultrasonography is simple, easily available, non-invasive, convenient and cost effective. The aim of the study was to determine the validity of ultrasound in diagnosis of the acute appendicitis in those with clinically diagnosed patients.Methods: A cross sectional study was carried out in Al-Karama teaching hospital for thirty months from the period of 1st June 2016 to 1st December 2018. All patients with suspected appendicitis underwent clinical evaluation then sent for US. Results of surgeries, where relevant, were compared against US results. Positive and negative appendices on histopathology were regarded in accordance to the criteria which was negative appendectomy was defined as normal looking appendix and absence of acute inflammation on histopathology while positive cases included appendices showing acute inflammatory changes. Sensitivity, specificity and overall accuracy was calculated.Results: A total of 435 patients with suspected appendicitis, males 224 (51.49%) and females 211 (48.50%) were included in present study. There were no significant differences between patients with positive and negative histopathology findings regarding presenting symptoms. There was a significant association between (cough sign, localized tenderness sign and pointing sign) and patients with positive histopathology findings. Regarding to the validity results of ultrasound in comparison to histopathology findings were  accuracy 87.6%, sensitivity 87.8%, specificity 85.3%, positive predictive value 98.6% and negative predictive value 62.8%.Conclusions: The ultrasonography had a good accuracy, sensitivity and specificity in diagnosing acute appendicitis cases. Negative with ultrasonography results should be re-examined with different diagnostic technique like CT-scan.
Acute mesenteric artery occlusion in hypobaric oxygen environment
Authors: Al-Saeed Mohammed
Published: February 2019

Background: Acute mesenteric ischemia represents a challenge in Taif and related districts where hypobaric oxygen may add to other risk factors as prevalence of diabetes mellitus and obesity. The aim of this retrospective study was to record and discuss the underlying risk factors, pattern of presentation, methods of diagnosis and results of treatment of acute mesenteric ischemia in Taif Tertiary Hospitals.Methods: In this chart review and database study, thirty-one patients met the inclusion criteria in the period from January 2009 to December 2017. The outcomes included demographics, risk factors, clinical findings, diagnostic and therapeutic methods, in addition to the mortality and follow up of the study population.Results: The commonest presenting symptom was abdominal pain (100%), of them 45.2% had marked peritoneal signs.  Diagnosis was established by CT angiography in 41.9% and after exploratory laparotomy in 58.1% of patients. Mesenteric artery thrombosis was the cause in 64.5% and embolism in 35.5%. In all patient’s necrotic bowel segments were resected followed by revascularization. Reoperation was performed in 32.3% of patients. Perioperative deaths were 41.9% and the overall mortality 58.1%.Conclusions: The findings of this study are not quite different from that performed on population living in normobaric oxygen environment except for a higher incidence of arterial thrombosis. Validation of these findings needs more standardized large prospective studies to avoid the impact of different confounding factors and the limited statistical power related to small sample sizes.
Study of morbidity pattern among geriatric patients attending outpatient department of a rural health training center, Maner of IGIMS, Patna
Authors: Kumari Seema , Bharati Dharmvir Ranjan , Yadava D. K. , . Shahin , Sinha Shivani , Kumari Anju
Published: February 2019

Background: With increasing life expectancy, number of old age people increased throughout the world, particularly more in the developing countries like India. Globally there are an estimated 605 million people aged 60 years and above. As the ageing population is increasing, the burden of their health problems is on a rise. To provide appropriate care for them there is a need to attain information about their morbidity pattern. Objectives: to study the morbidity pattern among the geriatric patients attending outpatient department of RHTC, Maner of IGIMS, Patna and to find out the difference in health problems between males and females, if any.Methods: This hospital based cross-sectional study was conducted during September 2017 to February 2018 among 98 elderly patients, aged 60 years or above, who  attended first time at the Out Patient Department of  rural health training center, Maner of IGIMS, Patna and who fulfilled inclusion criterion.Results: In this study majority had normal nutritional status. Amongst morbidity, prevalence of locomotors problems was highest (63.26%) followed by depression (42.85%), refractive error (20.4%), hearing loss (18.2%) and cataract (15.3). Locomotors problems were significantly higher in women (93.75%) as compared to the men (34%). However, the prevalence of depression, refractory error, hearing loss and cataract were not significantly associated with gender.Conclusions: There is a need to deliver comprehensive geriatric health care services for prevention and control of chronic diseases and address the dual burden of disease among the elderly to promote healthy ageing.
Marcelo Rougier y Juan Odisio, Argentina será industrial o no cumplirá sus destinos. Las ideas sobre el desarrollo nacional (1914-1980), Buenos Aires, Imago Mundi, 2018, 496 pp.
Authors: Vitelli Guillermo
Published: February 2019

No contiene resumen.
Multi-Site Protein Subcellular Localization Based on Deep Convolutional Neural Network
Authors: Cong Hanhan , Liu Hong , Chen Yuehui , Zhao Yaou , Wang Lei
Published: February 2019

Each part of internal structure of cells which is commonly mentioned as subcellular is highly ordered and interconnected has unique functions. The experiments show that deviated protein delivery to the corresponding subcellular causes of human disease. Studies of protein localization can clarify pathogenesis and find treatments. As protein subcellular localization has a very important position in the field of biology, the research in this area is extremely active. Most of the existing protein sub cellular localization methods are more suitable for single-site sub cellular localization. This paper proposed an algorithm based deep convolution neural network which is suit for multi-site protein subcellular localization and the algorithm is implemented on the human protein database to verify and analyze the performance. In order to further improve the classification result of the algorithm, it was combined ensemble learning and features fusion. It can be inferred from experiments that the proposed algorithm is effective in multi-site protein subcellular localization and the overall correct rate of classification is 59.13% which is higher than SAE, SVM and RF. The algorithm proposed in this paper is more uniform and less affected by the number of samples. When the data samples are different, the classification results will have a certain impact, but the overall classification is good. Besides ensemble learning and features fusion are effective for improving classification result.
Colonization and Development ofSirex noctilio(Hymenoptera: Siricidae) in Bolts of a Native Pine Host and Six Species of Pine Grown in the Southeastern United States
Authors: Bookwalter J.D. , Riggins J.J. , Dean J.F.D. , Mastro V.C. , Schimleck L.R. , Sullivan B.T. , Gandhi K.J.K.
Published: February 2019

Sirex noctilio F. (Hymenoptera: Siricidae) is a major exotic pest of pines (Pinus spp.) in the Southern Hemisphere and has become established in northeastern North America. We investigated the suitability of bolts of six economically and ecologically important U.S. pine species grown in the southeastern United States, including eastern white (P. strobus L.), loblolly (P. taeda L.), longleaf (P. palustris Miller), shortleaf (P. echinata Miller), slash (P. elliottii Engelmann), and Virginia (P. virginiana Miller) pines and its native Eurasian host, Scots pine (P. sylvestris L.), for S. noctilio reproduction. The properties of wood and resin of different pine species were also analyzed for possible correlates to S. noctilio's colonization and reproductive success on bolts. Sirex noctilio completed development on bolts within 4 mo of oviposition activities. Among the seven pine species, S. noctilio completed development in eastern white, Scots, and Virginia pines. Females tended to drill less on bolts with higher area and density of resin canals, as well as higher first 10-ring and radial stripspecific gravity. The resin of eastern white and Virginia pines had distinct extractive profiles, and eastern white pine may have two 3-carene chemotypes in the southeastern region.
A Bioética no contexto da Odontologia Hospitalar no Brasil
Authors: Lucas Andrea Cristina Marassi , Euclides Kelly Lene Lopes Calderaro , Do Nascimento Liliane Silva , Pontes Flávia Sirotheau Correa , Medeiros Amanda Menezes , Lira Pettra Blanco
Published: February 2019

O conceito de multidisciplinaridade é uma realidade crescente no cotidiano dos hospitais no Brasil. Neste sentido, vem ampliando na comunidade científica, estudos que evidenciam a relação direta entre a saúde bucal e a saúde geral do indivíduo. Desta forma, surge para o cirurgião-dentista o desafio de integração às equipes na prevenção e reabilitação dos pacientes internados nas unidades de terapia intensiva. As contribuições deste profissional são de suma importância para a melhoria da qualidade de vida e redução do tempo de internação dos pacientes, uma vez que muitas complicações podem ser minimizadas a partir da atuação da Odontologia no âmbito hospitalar. Neste contexto, há de se considerar a necessidade da Bioética, como ferramenta norteadora da assistência odontológica aos pacientes com necessidades especiais. Logo, o objetivo deste trabalho é realizar uma reflexão sobre a aplicação dos princípios básicos da Bioética na conduta do profissional de Odontologia hospitalar no Brasil
Memórias de Mulheres Seringueiras na Reserva Extrativista Rio Ouro Preto/RO: Linguagem, Cultura e Identidade
Authors: Alves Eva Da Silva , Pinto Auxiliadora Dos Santos , Caetano Renato Fernandes
Published: February 2019

Este trabalho apresenta o registro, a descrição e a análise de aspectos da linguagem das mulheres seringueiras e agroextrativistas da Reserva Extrativista Rio Ouro Preto (RESEX) em Guajará-Mirim/RO, evidenciando marcas identitárias culturais e mostrando, a partir das histórias de vida, que esse grupo possui um léxico específico, permeado por elementos constituidores de identidade, misticismo e subjetividade. Trata-se de um estudo sociolinguístico, de cunho etnográfico, no qual foram entrevistadas mulheres que residem na referida RESEX. Verifica-se, nas narrativas orais registradas e analisadas, que a linguagem desse grupo reflete marcas identitárias linguísticas e socioculturais que expressam saberes singulares
O Apocalipse De Belo Monte: Uma Cidade Frente À Construção Da Hidrelétrica
Authors: Guerra Gutemberg Armando Diniz , De Souza César Martins
Published: February 2019

Este texto reflete sobre os efeitos da construção da barragem de Belo Monte, visíveis nas ruas de Altamira, registrados em imagens fotográficas, evidenciados pelos discursos de seus moradores ou dos que exercem atividades profissionais e no comércio. Presentes em distintos momentos na cidade, acumularam-se notas e fotografias desde antes da implantação da barragem em 2009 até 2016, de maneira que além desse registro, aciona-se a memória dos pesquisadores, de diferentes atores e posicionamentos de atores sociais sobre Belo Monte para a elaboração deste texto. Conclui-se pela constatação do fim de um ciclo de ebulição e tumulto na vida social e econômica da cidade, para um momento de depressão, letargia, desaceleração, expectativa e desencanto provocados pela desmobilização dos recursos utilizados para este empreendimento