bluuebunny/crossref_metadata_2025 huggingface dataset:
PALEOGEOGRAFIA DA SEÇÃO CRETÁCEA NEOAPTIANA DO NORDESTE DA BACIA DE SERGIPE-ALAGOAS, BRASIL
Authors: SOUZA-LIMA Wagner , PIERINI Cristina , FISCHER Cristiano Mundstock , SILVA Bráulio Oliveira
Published: June 2023

A seção neo-aptiana da bacia de Sergipe-Alagoas engloba os registros geológicos iniciais das transgressões marinhas efetivamente responsáveis pela implantação do Oceano Atlântico Sul ao final do Cretáceo. Melhor conhecida na sua porção sul (sub-bacia de Sergipe), o comportamento destas transgressões é ainda pouco compreendido na porção nordeste da bacia (sub-bacia de Alagoas). Com base na análise integrada de dados bioestratigráficos e faciológicos de poços e afloramentos, este estudo apresenta mapas litoestratigráficos e reconstruções paleogeográficas para dois dos intervalos de tempo. Ambos marcam a transição entre sequências deposicionais essencialmente continentais (K40; Eo – Neo-Aptiano) para aqueles cujos sistemas deposicionais foram predominantemente marinhos (K50; Neo-Aptiano). Embora separadas por uma importante discordância, denominada pré-neo-Alagoas, as reconstruções permitiram observar que os processos deposicionais foram, de certo modo, semelhantes para as unidades estratigráficas abaixo e acima desta discordância. As diferenças evidenciam-se pelo avanço transgressivo durante a deposição da sequência K50, o qual teria se aproveitado dos mesmos compartimentos tectônicos mais subsidentes da sequência K40. Coincidentemente, estes mesmos compartimentos seriam novamente alvo de transgressões mais tardias, no Cenomaniano e entre o Daniano e o Ypresiano.
EVOLUÇÃO ESTRUTURAL DO DOMÍNIO INTERNO DA FAIXA BRASÍLIA MERIDIONAL NA REGIÃO DE ESTRELA DO SUL, MINAS GERAIS, BRASIL
Authors: SANTOS Bruna Letícia , SIMÕES Luiz Sérgio Amarante , SEER Hildor José
Published: June 2023

Na região de Estrela do Sul – MG, o domínio interno da Faixa Brasília é formada pelas unidades Goiandira E e Goiandira W, Complexo Monte Carmelo e Grupo Araxá. Compreende dois compartimentos estruturais: SW, que evidencia quatro fases deformacionais (D1, D2, D3, D4) e é caracterizado por uma foliação principal (S2) com alto ângulo de mergulho para SW, associada a uma lineação mineral N-S, com baixo caimento. A fase D3, responsável pelo desenvolvimento da foliação S3, de baixo mergulho, predominantemente para SE, associada a lineação mineral E-W com baixo ângulo de caimento, é responsável pela formação da foliação S3 e estruturação geral da área. O compartimento NE apresenta estruturas semelhantes às da fase D3 no compartimento SW, com uma foliação principal de baixo ângulo de mergulho associada a lineação mineral E-W de baixo ângulo de caimento, entretanto, as estruturas de alto ângulo não foram identificadas nesse compartimento. Essas características evidenciam uma evolução tectônica conjunta dos domínios estruturais a partir da fase D3. Paragêneses minerais das rochas do Grupo Araxá e do Ortognaisse Goiandira E evidenciam metamorfismo principal no compartimento SW associado à fase D2, de fácies anfibolito, zona da estaurolita (Gr. Araxá) e sillimanita.
ANÁLISE CRÍTICA DOS PRINCIPAIS MÉTODOS DE TRATAMENTO SUPERFICIAL ATUALMENTE UTILIZADO NO SETOR DE ROCHAS ORNAMENTAIS
Authors: BARBOSA Igor Coelho , SILVEIRA Leonardo Luiz Lyrio da
Published: June 2023

Atualmente a utilização das rochas de cunho ornamental tem intensificado a exploração mineral no Brasil. O quartzito é um exemplo da necessidade deste setor, principalmente por apresentar boa resistência físico-mecânica e química. Devido à alta exigência do mercado em busca de novos materiais, as empresas responsáveis pela produção destas rochas estão sendo obrigadas a apresentar novos métodos de tratamento para remoção da oxidação superficial. O objetivo deste trabalho foi selecionar um dos quartzitos mais comercializados atualmente e determinar qual modo de tratamento é o mais eficiente, de forma a propor novos procedimentos a serrem praticados nas indústrias. Para isso, foi feito um levantamento de dados em três empresas distintas, as quais utilizam em seu processo produtivo a mesma rocha, adquirida de um mesmo fornecedor, porém com métodos de aplicações para remoção da oxidação diferentes e usando o mesmo insumo, o ácido clorídrico, que é o item fundamental para a remoção da oxidação. Para a rocha estudada, a melhor técnica foi a aplicação do ácido por gravidade. Este trabalho visa colaborar para a diminuição do empirismo verificado no setor, considerando que as propriedades petrográficas de determinada rocha ornamental é fator primordial para melhor escolher o sistema para remoção de manchas de oxidação.
UTILIZAÇÃO DE ENSAIOS DE CAMPO PARA A AVALIAÇÃO DA RESISTÊNCIA MECÂNICA DE UM ATERRO SANITÁRIO DE RESÍDUOS SÓLIDOS URBANOS (RSU)
Authors: CORDEIRO  DA SILVA Roberto Antonio , MOURA Alfran Sampaio , CARNEIRO Andressa de Araújo , PINHEIRO Claver Giovanni , SILVA VASCONCELOS Sônia Maria
Published: June 2023

Nesse estudo, avalia-se o comportamento geomecânico dos resíduos sólidos urbanos (RSU), com ênfase na resistência ao cisalhamento, do Aterro Sanitário Metropolitano Oeste de Caucaia (ASMOC). Foram realizados ensaios em laboratório para caracterização física dos RSU, sondagens à percussão (SPT) e ensaios de prova de carga direta (PCD) em diferentes momentos no tempo, em uma Célula Experimental e no maciço antigo do aterro já existente. Posteriormente, com base nos resultados dos ensaios PCD realizadas, determinou-se a capacidade de carga da célula experimental e do aterro antigo. A partir dos ensaios SPT realizados não foi constatado tendência de elevação ou diminuição do índice de resistência à penetração (NSPT) ao longo do tempo. A partir das PCD realizadas ficou evidente, tanto na célula experimental quanto no aterro antigo, uma relação bastante linear entre a pressão aplicada e o recalque obtido com a placa, indicando ausência da ruptura física na massa de resíduos solicitada. Percebeu-se a presença do efeito fibra no comportamento dos resíduos apenas para o aterro antigo. De forma geral, o aterro antigo apresentou rigidez e capacidade de carga mais elevada que o da célula experimental.
Direito Penal do clima: a autonomia do equilíbrio climático enquanto bem jurídico-penal
Authors: Pertille Marcelo Bauer
Published: June 2023

A presente pesquisa tem como objetivo geral investigar a possibilidade de tutela penal autônoma do equilíbrio climático tendo como base os padrões de criminalização da teoria do bem jurídico. Dessa forma, este estudo investiga se, a partir da teoria do bem jurídico-penal, há legitimidade para a tutela do equilíbrio climático enquanto valor autônomo frente ao bem ambiental. A hipótese levantada é a de que o equilíbrio climático atende aos padrões da teoria do bem jurídico, reunindo condições de se apresentar tal qual um legítimo bem jurídico supraindividual, apresentando autonomia frente ao bem ambiental em razão de suas especificidades sistêmicas. Para alcançar o objetivo proposto, serão analisados, primeiramente, os principais conceitos atrelados ao equilíbrio climático, seguindo-se com a apresentação das principais consequências das crises climáticas exaltadas pelo Painel Internacional das Mudanças Climáticas da Organização das Nações Unidas. Na segunda parte, estabelecer-se-á a teoria do bem jurídico enquanto padrão atento às estruturas do Estado de Direito compreendido sob vieses ecologizados para os processos de criminalização e controle material da legalidade de tipos penais. No terceiro tópico, será averiguada a capacidade do bem ambiental ser compreendido enquanto valor com dignidade penal para, enfim, ser viável a análise de o equilíbrio climático ser compreendido com valor penal autônimo. Ao final, concluiu-se que o equilíbrio climático apresenta condições de satisfazer os requisitos do bem supraindividual, invocando autonomia de tutela frente ao bem ambiental. Para o desenvolvimento da pesquisa, utilizou-se a metodologia jurídico-teórica, com fins descritivo e explicativo, por meio de abordagem hipotético-dedutiva.
A tentativa na omissão imprópria: um esboço sobre delimitação entre atos preparatórios e início da execução
Authors: Góes Guilherme , Santin Janice
Published: June 2023

A diferenciação entre os atos preparatórios e o início da execução nos casos omissivos impróprios ainda resta muito incerta. Em primeiro lugar, o presente estudo busca demonstrar a possibilidade de punição da tentativa nas situações de omissão imprópria. Na sequência, ele apresenta os diversos posicionamentos que podem ser adotados como forma de delimitação do início da tentativa nos casos omissivos impróprios. Nessa apresentação o trabalho faz uma análise crítica sobre cada uma das posições, expondo os argumentos favoráveis e contrários a cada uma delas. Além disso, apontam-se também argumentos sobre a adequação de cada uma das teorias ao ordenamento jurídico brasileiro. Complementa-se o estudo com uma análise sobre as consequências e dificuldades processuais enfrentadas por cada uma das possíveis teorias. Ao fim, conclui-se que apenas as posições que adotam um critério de perigo concreto são compatíveis com a lei brasileira. Para seu desenvolvimento, o presente trabalho recorreu à análise bibliográfica, legislativa e também jurisprudencial.
O status ontológico dos estados mentais
Authors: Stuckenberg Carl-Friedrich
Published: June 2023

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Mahremiyet Eğitiminde Bir İhtiyaç Analizi: Anne/Baba Eğitimi
Authors: İDER Saadet , TAVUKÇUOĞLU Mustafa
Published: June 2023

Mahremiyet eğitimi, örgün eğitimde yer bulmadığı için çoğunlukla ebeveynlerin sorumluluğuna bırakılmış bir eğitim durumundadır. Bu sebeple anne/babaların mahremiyet eğitimi konusundaki yeterlilik durumu, din eğitimi araştırmalarında yer bulması gereken bir problemdir. Yaygın din eğitimi kapsamında anne/babalara sunulan eğitimin içeriğinde mahremiyet konusu kısmen yer bulsa da, ebeveynler bu konuda bağımsız bir eğitime ihtiyaç duymaktadır. Bu yönüyle anne/babaların eğitim ihtiyacı, din eğitiminin bir problem olarak kendini göstermektedir. Bu çalışma, mahremiyet eğitiminde anne/baba eğitimine duyulan ihtiyacı tespit etmeyi amaçlamaktadır. Araştırmada yetişkinlerin mahremiyet eğitimine ilişkin görüşlerine başvurulmuştur. Çalışma grubunu, maksimum çeşitlilik örnekleme yöntemi ile belirlenen toplam 21 kişi oluşturmuştur. Nitel araştırma yöntemiyle gerçekleştirilen çalışmada görüşme tekniği kullanılmış, veriler içerik analizi ile çözümlenmiştir. Araştırma sonuçları, ebeveynlerin mahremiyet hakkında eğitime ihtiyaç duyduğunu ortaya çıkarmıştır.
The National Reader Survey
Authors: van Dalen-Oskam Karina
Published: June 2023

This chapter describes how the 2013 Dutch National Reader Survey was
organized and what the main outcomes were, in such a way that the survey can
be adapted for use in other countries or language areas. It presents the criteria
for the selection of the four hundred plus one novels that participants could rate
and zooms in on the four main categories of books on the list. This is followed by
a description of the kinds of readers that took part and which books received the
highest and lowest mean scores for general quality (how good the book was) and
literary quality. It elaborately quotes from the motivations readers gave for their
ratings and analyses the main trends by applying keyword analysis.
The Riddle of Literary Quality Solved?
Authors: van Dalen-Oskam Karina
Published: June 2023

The chapter sums up the main results of the project The Riddle of Literary
Quality. For Dutch readers in 2013, genre fiction had no chance of literary fame.
Literary novels with a more complex or difficult language, structure, or content
received higher ratings. Male-authored literary novels were still more highly
valued than those written by female authors and this reflects the Dutch society
in which the conventions about literary quality are embedded. Being aware of
underlying prejudices may lead to changes in the future and suggestions are done
how to conduct follow-up research into, for example, the literary canon. More
methodological research is needed into the influence of amount of dialogue,
first-person or third-person perspective, and narrative tense.
The War of Peace and Legacy of Social
Anomie
Authors: Blanco John D.
Published: June 2023

This chapter analyzes the euphemisms of peace and pacification
by examining the role they played in the legal rhetoric of conquest. This
rhetoric reflects how the conquest and colonization of the Philippines
actually happened; and that its unfolding in most respects did not differ
from the conquest and colonization of the Americas. What was different,
however, was the way the Spaniards insisted on remembering the conquest;
specifically, through a quasi-legal framework that recorded the conquest
as inseparable from the legitimacy of Spanish rule overseas. The discourse
of pacification masked the permanence of conquest measures (invasion,
plunder, impunity) as well as a state of social anomie on the missionary
frontier.
Monastic Rule and the Mission As
Frontier(ization) Institution
Authors: Blanco John D.
Published: June 2023

Following Marcelo H. del Pilar’s insight that “Spain abdicated
its sovereignty in favor of monk rule in the Philippines,” this chapter
establishes the legal and institutional bases of Spanish rule overseas,
with attention to the role assigned to the religious Orders in the
aftermath of the so-called conquest of the Philippines. Specifically,
I analyze the peculiar character of friar and Jesuit authority: while
both served as agents of the Crown, neither were subject to the Crown
or even official Church laws and authority. The exploration of this
paradox reveals the full implications of the institutional anarchy of
Spanish rule overseas.
Stagings of Spiritual Conquest
Authors: Blanco John D.
Published: June 2023

This chapter juxtaposes the project of spiritual conquest as
the dual project of religious conversion and resettlement, against the
haphazard spread of Christianity as the ideology and propaganda of
the Spanish conquest. Both themes appear regularly throughout the
missionary chronicles, which documented the progress of each monastic
Order (including the Jesuits) in establishing doctrina, a word that came
to refer at once to a Christianized population, a mission-town, and the
inculcation of the basic tenets of Catholic orthodoxy – in Spain’s overseas
possessions. The juxtaposed themes of missionary progress and social
disintegration appear in a language and imaginary that represent the
native experience of deracination as episodes of spiritual “battle”: shot
through with magic, demonic possession, monsters, miracles, and divine
apparitions.
Miracles and Monsters in the
Consolidation of Mission-Towns
Authors: Blanco John D.
Published: June 2023

Representations of the “efficacy of divine grace” informed the
projects of conversion and concentrated settlement, while also serving
as a cipher for recording the native experience of deracination and state
of social anomie. The prose of spiritual conquest allowed the friars and
Jesuits to promote the practical usefulness of apparitions and miracles.
But for the presumably conquered peoples under Spanish rule, the reception
of miracles and apparitions suggests a collective ambivalence and
uncertainty regarding the prospect of abjuring native understandings
of the spirit world for the faithless promises of concentrated settlement.
The theo-politics of undeception masked an underlying conflict around
the autonomy of native Indians to assign values (social, economic, and
otherworldly) to their environment and community / communities.
Colonial Racism and the Moro-Moro
As Dueling Proxies of Law
Authors: Blanco John D.
Published: June 2023

This chapter concerns the dual articulation of colonial racism
and native custom in the period of the mission’s decadence. Beginning with
a famous letter written by Fr. Gaspar de San Agustín about the nature and
character of the Indian, I argue that San Agustín’s pessimism foregrounds
the insurmountable obstacles to the successful resettlement, conversion,
and acculturation of the subject population. Juxtaposed to colonial racism
is the emergence of another, phantom discourse, referred to as native
custom [ugalí]. For native principales who witnessed the erosion of their
privileges as well as the dissolution of their communities, native custom
names a form of legitimacy that, under certain circumstances, may occupy
the (absent) place of law more effectively than religious authority.
Jekyll and Hyde: TV Horror’s
Incorporation of Other Genres and
Audiences
Authors: Rendell James
Published: June 2023

Employing interpellation as a reading strategy, the chapter analyses how
TV horror hails genre fans and wider audiences, supporting brand identities
and horror’s mainstreaming on television: US premium subscription
channels HBO’s Carnivále and Showtime’s Masters of Horror episode
‘Imprint’ incorporate the cinematic to appeal to quality audiences. British
teen digital channels E4 and BBC3 hybridize zombies with reality TV as
multigeneric interpellation in Dead Set and I Survived a Zombie Apocalypse
respectively. Casting Lady Gaga in American Horror Story hails wider music
fans. The chapter also offers the original term ‘flexi-serial’ as a distinct
form of storytelling that facilitates cult and mainstream consumption
habits. Finally, Stranger Things supports Netflix’s transgenerational audience
remit via nostalgia and gradational intertextuality that engenders
transmediality.
Digital Crypt Keepers: Informal
Digital Dissemination and
Consumption of Post-TV Horror
Authors: Rendell James
Published: June 2023

The chapter focuses on informal circulation and consumption as a fundamental
component of post-TV horror, offering the original concept
‘Only-Click TV’. Exploring Only-Click TV’s transcultural and temporal
dynamics, the chapter analyses global audiences downloading The Walking
Dead during broadcast as just-in-time fandom. The chapter then considers
how Only-Click TV is important for mining horror television from
yesteryear, looking at Japanese horror series Rasen and Mexican horror
anthology Hora Marcada. Accounting for what Only-Click TV lacks as
a format, the chapter argues DVD/Blu-ray’s symbolic value can elevate
horror television. Finally, the chapter explores industry’s incorporation
of Only-Click TV discourse: BBC3 adopted Only-Click TV functionality
when becoming online-only whilst Masters of Horror uses discourses of
censorship in paratextual marketing of ‘Imprint’.
Introduction – TV Horror: What a
Time to Be Alive… and Undead
Authors: Rendell James
Published: June 2023

This chapter considers the often-overlooked longstanding connections
between horror and television, before reading the genre’s graphic shift as
emblematic of the new/current golden age of TV horror. Located within
a post-TV paradigm, the chapter considers television’s portalization facilitated
by internet technologies that alter the production, distribution,
curation, and consumption of horror TV. A pertinent feature of posttelevision,
the chapter examines the complexity of transmedia: fostering
hyperdiegetic depth and commercial opportunities for industry players,
and outlets for fan participatory practices. Finally, the chapter develops
the abject spectrum model, broadening audiences’ affective engagement
with horror beyond being scared. It also considers audiences’ ideological
deconstructing and aesthetical evaluation of horror. The chapter ends by
providing an overview of the book.
Edeka Nord sichert sich gegen steigende Zinsen ab
Authors: Tewes Werner
Published: June 2023

Edeka Nord reagiert auf die Zinswende. Das Unternehmen hat sich gegen steigende Belastungen für einen Teil der variabel verzinslichen Darlehen abgesichert. Große Investitionsprojekte sorgen für einen erhöhten Kapitalbedarf.
Insolvenzplan für Hakle steht
Authors: Brändlein Philip
Published: June 2023

Für den bisher als Hakle GmbH firmierenden Tissuehersteller aus Düsseldorf geht es weiter. Der Insolvenzplan steht, künftig will das Unternehmen unter neuem Namen für Handelsmarken produzieren.
Schweden-Schick zum Billigpreis
Authors: Rosbach Britta
Published: June 2023

In Kerpen betreibt der schwedische Nonfood-Discouter Rusta international seinen 200. Markt und zugleich die achte Filiale in Deutschland. Der Händler verkauft Wohnaccessoires und Saisonartikel, kombiniert mit Schnelldrehern wie Drogeriewaren, Tiernahrung und Snacks. Und das alles im Ikea-ähnlichen Look. Britta Rosbach

Ungewöhnlicher Sortimentsmix

Marken dominieren bei Food
Fressnapf geht bei Kassen neuen Weg
Authors: Rode Jörg
Published: June 2023

Fressnapf erweitert seine für Omni-Channel optimierte IT-Landschaft um ein neues Kassensystem. Der Händler war dafür Entwicklungspartner des IT-Hauses Enfore. Dem gelingt damit der Sprung in die erste Liga der Anbieter von POS-Systemen für große Filialisten.
TRANSFORMING SERVICE OPERATIONS WITH AI: A CASE FOR BUSINESS VALUE
Authors: Vijayakumar Harsha
Published: June 2023

Artificial Intelligence (AI) has rapidly become a critical technology for businesses seeking to improve efficiency and profitability. One area where AI is proving particularly impactful is in service operations management, where it is used to create AI-powered service operations (AIServiceOps) that deliver highvalue services to customers. AIServiceOps involve the use of AI to automate and optimize various business processes, such as customer service, sales, marketing, and supply chain management. The rapid development of Artificial Intelligence has prompted many changes in the field of Information Technology (IT) Service Operations. IT Service Operations are driven by AI, i.e., AIServiceOps. AI has empowered new vitality and addressed many challenges in IT Service Operations. However, there is a literature gap on the Business Value Impact of Artificial intelligence (AI) Powered IT Service Operations. It can help IT build optimized business resilience by creating value in complex and ever-changing environments as product organizations move faster than IT can handle. So, this research paper examines how AIServiceOps creates business value and sustainability, basically how AIServiceOps makes the IT staff liberation from a low-level, repetitive workout and traditional IT practices for a continuously optimized process. One of the research objectives is to compare Traditional IT Service Operations with AIServiceOPs. This paper provides the basis for how enterprises can evaluate AIServiceOps and consider it a digital transformation tool. The paper presents a case study of a company that implemented AI-powered service operations (AIServiceOps) and analyzes the resulting business outcomes. The study shows that AIServiceOps can significantly improve service delivery, reduce response times, and increase customer satisfaction. Furthermore, it demonstrates how AIServiceOps can deliver substantial cost savings, such as reducing labor costs and minimizing downtime.
Effect of Different pH on Embryogenesis and Hatching Rate of Srikandi Strain Tilapia Eggs (Oreochromis aureus X Oreochromis niloticus) in Incubator
Authors: Saad Moch , Shaleh Fuquh Rahmat , Rahayu Agung Pamuji , Fanni Norma Aprilia
Published: June 2023

Tilapia (Oreochromis niloticus) is one of the freshwater fish species which is a leading commodity in the aquaculture sector. The use of an incubator in hatching fish eggs can produce seeds with relatively the same age, the environment is more controlled so it will be easier to manipulate environmental factors that can affect hatching eggs to produce seeds of superior quality. This study aims to determine the description of embryogenesis and hatching rate of Srikandi strain tilapia eggs hatched at different pH. The experimental design used was a completely randomized design (CRD). The treatment consisted of four treatments, namely A (pH 6), B (pH 7), C (pH 8) and D (pH 9) with four replications. Statistical analysis used ANOVA (Analysis of Variance) and to find out the difference between one treatment and another, Duncan's Multiple Range Test was performed. The results showed that different pH treatments had an effect on the embryogeensis of Srikandi tilapia and also had a very significant effect on the hatchability of Srikandi tilapia eggs. The average hatchability of Srikandi tilapia eggs was highest in treatment B (pH 7) of 87.5% although it was not significantly different from treatment C (pH 8) of 80%.
POLIMORFISME CYP2C19*2 TERHADAP AGREGASI PLATELET DAN KEJADIAN KARDIOVASKULAR PADA PASIEN PENYAKIT JANTUNG KORONER
Authors: Utami Primanitha Ria , Rochmawati Ike Dhiah , Fandinata Selly Septi
Published: June 2023

Coronary Heart Disease (CHD) is a cardiovascular disease that can caused by the presence of coronary artery plaque blockage. Clopidogrel is one of antiplatelet therapy in CHD patients. CYP2C19 *2 polymorphisms can reduce the effectiveness of clopidogrel active metabolites. This research was conducted at RSUD Sidoarjo East Java from November to December 2017continued monitoring of cardiovascular events to March 2018. The research method used is a method Polymerase Chain Reaction (PCR) and the Light Transmittance Aggregometry (LTA) method for platelet aggregation measurement. From 25 sample inclusion,there are wild type alleles (bp values ​​around 120 bp; 1 patient), homozygous alleles (bp values ​​around 169 bp; 18 patients) and allele heterozygotes (bp values ​​around 120bp, 169bp; 6 patients). The most common type of polymorphism is allele homozygotes. There is one patient hyperaggregation and cardiovascular events after being monitored for 3 months. Analysis relationship between CYP2C19*2 genetic polymorphisms with platelet aggregation and cardiovascular events, using the kruskal wallis test. The result is no significant relationship between CYP2C19*2 polymorphisms with platelet aggregation (p=0.512), as well as cardiovascular events did not make any difference which is also significant (p=0.426). The results of the association of platelet aggregation with cardiovascular events showed significant differences (p=0.027).
UJI EFEKTIVITAS ANTIBAKTERI SABUN CUCI TANGAN YANG MENGANDUNG PERASAN JERUK KALIMANSI (Citrofotunella microcarpa)
Authors: Dominica Dwi , Dian Handayani  , Delia Komalasari  , Buistu Arbaa Nuyuh Putri  , Dinda Zulkarnain  , Kurnia Hafidzah  , Rizki Hadi Wibowo
Published: June 2023

Kalamansi orange with the Latin name Citrofortunella microcarpa is an agricultural commodity that has been widely developed in Bengkulu Province. This study aims to determine the anti-bacterial activity of hand washing soap containing kalimansi orange juice against pathogenic bacteria, one of which is the bacteria S. aureus and E. Coli. The method used in this research is disc paper diffusion. The results of the antibacterial activity test were marked by the formation of a clear area around the disc paper on the media, the largest diameter of inhibition for S. aureus bacteria was given by F2, namely 30.595 mm and the largest diameter of inhibition for E. coli bacteria, which was given by F3, namely 28, 98mm so that it gets a very strong category. When compared to the comparator handsoap in the market HSFFLS @ the inhibitory power of hand washing soap from kalimansi orange juice was also greater both against S.aureus and E. Coli bacteria. The results of the inhibitory activity test between gram-positive and gram-negative bacteria showed that hand washing soap containing kalimansi orange juice had a greater potential for S. aureus gram-positive bacteria compared to Gram-negative bacteria E. Coli.
PERBANDINGAN EFEKTIVITAS CEFTRIAXONE DAN CEFOTAXIME PADA PASIEN ANAK DEMAM TIFOID DI RUMAH SAKIT MITRA SIAGA
Authors: Pratiwi Rosaria Ika , Anggy Rima Putri
Published: June 2023

Ceftriaxone and cefotaxime are the antibiotics of choice for the treatment of typhoid fever. The effectiveness of antibiotics can be seen based on the length of stay in the hospital. This study aims to determine the characteristics of children with typhoid fever and the comparison of the effectiveness of ceftriaxone and cefotaxime on the length of stay in children with typhoid fever at Mitra Siaga hospital. The study was an observational analytic study with a sample of 100 medical records for children with typhoid fever who had met the inclusion and exclusion criteria. The effectiveness analysis was processed using the Mann-Whitney method. The results showed that the characteristics of the children with typhoid fever were 43% female (43 people) and 57% male (57 people), 52% (52 people) patients aged 1-7 years, and 48% (48 people). aged 8-14 years, length of stay 2 days 5% (5 people), 3 days 48% (48 people), 4 days 37% (37 people), 5 days 6% (6 people), 6 days 2% (2 person), 7 days 1% (1 person), and 8 days 1% (1 person). There was no difference in the effectiveness of ceftriaxone and cefotaxime on length of stay in patients with typhoid fever at Mitra Siaga hospital (P = 0.997> 0.05).
MIKROGRANUL MUKOADHESIF EKSTRAK DAUN SALAM (Syzygium polyanthum (Wight.)) DENGAN PERBEDAAN POLIMER HPMC DAN KITOSAN
Authors: Rustiani Erni , Bina Lohita Sari  , Dea Safira Nur Izmah
Published: June 2023

Bay leaf (Syzygium polyanthum (Wight.) contains polyphenolic compounds that are beneficial in the treatment of hypercholesterolemia by reducing Low Density Lipoprotein (LDL) levels. The dosage form of mucoadhesive microgranules is able to prolong the active substance contact time with the mucosa give better therapeutic effect. This study aims to make mucoadhesive microgranules of bay leaf extract with different polymers of Hydroxy Propyl Methyl Cellulose (HPMC) and chitosan. There were 4 formulas, namely formula I (25% HPMC), formula II (30% HPMC), formula III (25% chitosan) and formula IV (30% chitosan). Microgranules were prepared by wet granulation method. Microgranule test parameters include moisture content, flow rate, angle of repose, particle size, total polyphenol content, wash off test and morphology test. The results of this study of mucoadhesive microgranules of bay leaf extract showed that all formulas had water content <5%, flow rate and angle of repose including easy flow. The size of the microgranules was in the range of 48.7 – 637 μm with a total polyphenol content of 4.15 – 4.27%. The results of the wash off test showed that the total polyphenol content of microgranules in the stomach was 1.33 - 3.23% (31.97 - 75.63%) and in the intestine 1.26 - 3.76% (27.95 - 88.03%). The best mucoadhesive microgranules of bay leaf extract used 30% HPMC polymer.
HEALTH RELATED QUALITY OF LIFE: CHRONIC KIDNEY DISEASE DENGAN HEMODIALISA MENGGUNAKAN INSTRUMEN EQ-5D-5L DI PEKANBARU
Authors: Firmansyah Ferdy , Tiara Tri Agustini  , Tri Murti Andayani
Published: June 2023

Chronic Kidney Disease (CKD) is a kidney disorder that continues to increase the globally and its also irreversible. Hemodialysis (HD) performed by CKD patients with severe conditions. Quality of life is one indicator of the success therapy patients CKD with HD. In addition to clinical conditions, the characteristics of patients can be affected to the quality of life. The aims of this study is to see the effect of the characteristics of CKD with HD of the Score Index utility. Its were measured using the EuroQuality of 5-dimensional 5 levels (EQ-5D-5L). The study was performed with the observational conversion using a cross sectional design in the CKD population in Pekanbaru hospital. The EQ-5D-5L questionnaire is given to 122 patients to measure the score utility. Different index score utility based on the characteristics of the tested patients using Mann Whitney and Kruskal Wallis. Based on the study, the average value of Pasa Pasa patients with HD patients was 0.24 ± 0.27. Dimensions of anxiety / depression and pain / discomfort of 6.56% with very severe problems and 2.46% could not move. Based on the anysis results, there are differences in utility values based on age characteristics, education levels, and commorbids (p <0.05).
APLIKASI METODE OPTIMASI CENTRAL COMPOSITE DESIGN DALAM FORMULASI SEDIAAN GEL NANOPARTIKEL LIPID DENGAN BAHAN AKTIF 4-n-BUTILRESORCINOL
Authors: Dwiastuti Rini , Ni Kadek Dwi Putri Kusuma Dewi
Published: June 2023

Lipid nanoparticle is one of the nanoparticle dosage forms that have a particle size of 1-100 nm. Lipid nanoparticle systems aggregation causes an increase in particle size with storage time so that a carrier is needed that can reduce the aggregation. The lipid nanoparticle system formulated in gel preparations can add to the matrix thereby reducing the aggregation. Central Composite Design (CCD) is one part of the experimental design of Response Surface Methodology that can be used to determine the optimization of gelling agents and humectants in the formulation of lipid nanoparticle gel preparations. The aim of this study was to obtain the optimum composition of carbopol 940 and propylene glycol with the active ingredient 4-n-butylresorcinol using the optimization method of Central Composite Design. This research is an experimental study with independent variables, carbopol 940 and propylene glycol and the dependent variable, the physical properties and physical stability of the gel preparation. The results of this study were carbopol 940 of 0.46 grams and propylene glycol of 9.23 mL were determined as the optimum point obtained from the smallest point in the optimum area using the CCD method.
PENGARUH PELATIHAN FARMASI KLINIK TERHADAP PENINGKATAN KOMPETENSI APOTEKER DI PUSKESMAS PROVINSI BANTEN DI ERA PANDEMI COVID-19
Authors: Yusransyah  , Ahmad Sofan  , Tuty Sriwahyuni  , Tuty Sriwahyuni  , Lydya Elfira Sari Nasution  , Raiyan
Published: June 2023

Pharmacy services by pharmacists at public health centers in Banten province are not yet optimal. This can be seen from the number of use of antihypertensive drugs and the prevalence of hypertension which is increasing from year to year and is one of the biggest causes of death in Banten province for the category of non-communicable diseases. This requires pharmacists to further optimize their role by increasing competence through training. This study aims to assess the level of knowledge and ability of pharmacists at the health center in Banten province and to find out whether there is a significant effect before and after clinical pharmacy training for pharmacists at the public health center. This study is a pre-experimental study with a one-group design that was given a pre-test and posttest. The training covers two main topics. The first topic is about communication skills and the second topic is about anti-hypertensive therapy, with various case studies at the public health center. The results of this study showed that the average score after training was 71.64 which was higher than the score before training, which was 51.23. A total of 72 pharmacists (out of a total of 73 pharmacists) had a higher score after training than before training. The counseling value of the training participants did not meet the standards, but the training pharmacists gained experience and good counseling techniques for hypertension patients at the Puskesmas, which could be implemented in their respective workplaces. Online training in the pandemic era has been proven to increase the knowledge and ability of pharmacists in providing pharmaceutical services on antihypertensives at the Banten provincial health center as assessed from the test results before and after the training.
EVALUASI KEPUASAN ANGGOTA PD IAI KALIMANTAN SELATAN TERHADAP PENGGUNAAN APLIKASI SIAP MENGGUNAKAN METODE EUCS (END USER COMPUTING SATISFACTION)
Authors: Rizki Muhammad Ikhwan , Surya Wahyudi  , Herningtyas Nautika Lingga
Published: June 2023

The Indonesian Pharmacists Association or Ikatan Apoteker Indonesia (IAI) is a professional organization of pharmacists in Indonesia. IAI has management at Central, Regional, and Branches. Organizational services for each IAI member use the Pharmacist Information System Application or Sistem Informasi Apoteker (SIAp). Evaluation of satisfaction in the Information System can use the EUCS (End User Computing Satisfaction) method. The purpose of this study was to determine the level of satisfaction of South Kalimantan pharmacists on the use of the SIAp application and management services. The research method uses an analytical survey with a cross sectional design. The instrument used is a questionnaire that has been tested for validity and reliability. This research has been submitted to the Research Ethics Commission. The population of this research is 1.151 pharmacists in South Kalimantan. Respondents who filled out the questionnaire were 540 pharmacists (95% confidence level). Questionnaires were distributed using a Google form that assessed the SIAP application from the aspects of Content, Accuracy, Format, Easy of User, and Timeliness. The results of the questionnaire were analyzed using a Likert scale, then the percentage of satisfaction levels interpreted with the categories very high (75.01 - 100%), high (58.34-75), less (41.65-58.33), low (24.98 -41.66), and very low (0-24.99). The results showed that members' satisfaction with the SIAp application from the aspect of Content 79.83% (very high), Accuracy 81.47% (very high), Format 82.32% (very high), Easy of Use 78.36% (very high), and Timeliness 75.52% (very high). Member satisfaction with Branches is 79.07% (very high), Regional is 77.93% (very high), and Central is 75.27% (very high). Conclusion: The level of satisfaction of PD IAI South Kalimantan Pharmacists with the SIAp Application is very high. Branch, Regional, and Central Services are very high.
IDENTIFIKASI DAMPAK INTERAKSI OBAT ANTIHIPERTENSI TERHADAP TEKANAN DARAH PADA PASIEN GERIATRI HIPERTENSI YANG DIRAWAT INAP DI RSUD DR SOEDARSO PONTIANAK
Authors: Yuswar Muhammad Akib , Egida Rachmadani  , Eka Kartika Untari
Published: June 2023

Hypertension is one of cardiovascular diseases in geriatrics. Hypertensive geriatric patients require a combination of more antihypertensives to achieve blood pressure targets, it can cause high risk of polypharmacy. Polypharmacy in hypertensive geriatric patients is at high risk of drug interactions that can affect their blood pressure. This study aims to identify the interactions of antihypertensives based on mechanism and severity and also to determine whether there is a change in blood pressure caused by drug interactions in geriatric hypertensive inpatients at RSUD Dr Soedarso on January – June 2019. Data were collected retrospectively from 38 patients’ medical records, using total sampling technique. Data were analyzed descriptively using E-book Stockley’s Drug Interaction and Drug Interaction Checker on medscape.com, drugs.com. There were 28 patients (73%) who may experience drug interactions with a total of 85 cases. Drug interactions with moderate severity and pharmacodynamic interaction mechanism often occur in a row were 61 cases (72%) and 79 cases (93%). There were a decrease and increase blood pressure, which in a row were 23 and 4 patients. The decrease of patients’ blood pressure estimated caused by synergistic drug interactions of antihypertensives and adjustment of each drug dose that has potential to increase blood pressure.
TINGKAT KEPUASAN MASYARAKAT TERHADAP PELAYANAN PENGGALIAN INFORMASI SWAMEDIKASI OLEH PETUGAS APOTEK PADA MASA PANDEMI COVID-19 DI KECAMATAN TUAH MADANI KOTA PEKANBARU TAHUN 2021
Authors: Muharni Septi , Putri Zulnandita  , Fina Aryani  , Rahayu Utami  , Mustika Furi
Published: June 2023

Self-medication is an effort made to overcome complaints or pain by using medicines purchased without a doctor's prescription. One of the stages in this self-medication is extracting information. Information gathering aims to collect or dig up information from patients regarding the symptoms experienced by patients so that pharmacy staff are assisted in making decisions and recommending the correct therapy for patients. To determine the quality of information mining services, one way is to find out the community's satisfaction with the self-medication information mining service. Satisfaction is an important part of health services because respondent satisfaction cannot be separated from the quality of health services. The purpose of this study was to determine the level of community satisfaction with the service of extracting information on self-medication and providing drug information by pharmacists during the COVID-19 pandemic in the Tuah Madani sub-district, Pekanbaru City in 2021 based on five (5) dimensions of service quality, namely reliability, responsiveness, empathy, assurance and tangibles. This research is observational/survey research with a descriptive research design using quantitative analysis. Sampling was done by non-probability sampling method on 100 respondents. The results showed that respondents' satisfaction was in the aspect of reliability 66%, responsiveness 76.2%, empathy 74.4%, assurance 75.25% and tangibles 82.12%. This shows that the community as a whole is satisfied with the services provided by pharmacists.
PENGARUH EKSTRAK DAUN EKOR NAGA (Rhaphidophora pinnata (L.f) Schott) TERHADAP KADAR MALONDIALDEHID DARAH PADA TIKUS DIABETES YANG INDUKSI ALOKSAN
Authors: Sani K Fathnur , Rahman Havizur , Yuliawati Yuliawati , Samudra Agung Giri
Published: June 2023

Ekor Naga (Rhaphidophora pinnata (L.f) Schott) leaves is a traditional medicinal plant that contains secondary metabolites of alkaloids, flavonoids, saponins, and tannins, which have antioxidant effects. Uncontrolled diabetes mellitus will be one of the triggers for high free radicals in the body. This study aims to determine the effect of the effect of ekor naga leaves extract which has potentian as an antioxidant on malondialdehyde levels as a prooxidant marker in alloxan-induced diabetes mellitus rats. The reseaech method used a post test only control group design. The test animals used were 20 animals, each group of 5 test animals. Group 1: Positive Control (Glibenclamide 10 mg/Kg BW), Group 2: Negative Control (Na CMC 0,5%), Group 3: Ekor Naga Leaf Extract 250 mg/Kg BW, and Group 4: Ekor Naga Leaves Extract 500 mg/Kg BW. The data taken is the level of malondialdehyde in the blood. The results were analyzed using One-way ANOVA with a 95% confidence level. The results showed that the ethanolic extract of the ekor naga leaves had a role in reducing Malondialdehyde or lipid peroxide in the blood in diabetic rats where the best dose is 500 mg/Kg with malondialdehyde yield of 0,569 nmol/mL. Followed by a dose of 250 mg/Kg BW with malondialdehyde value of 2,144 nmol/mL.
UJI KARAKTERISTIK FISIK DAN HEDONIK DARI ANTIAGING SLEEPING MASK DENGAN EKSTRAK KULIT BUAH DELIMA MERAH
Authors: Mayangsari Fransisca Dita , Djati Wulan Kusumo  , Zurotul Muarifah
Published: June 2023

Red pomegranate peel extract (RPPE) contains ellagitannin. This compound has an antioxidant effect. Therefore,this extract has good potential as an active ingredient in anti-aging cosmetics. However, applying the extract directly to the skin is inconvenient. So in this study RPPE was formulated into a sleeping mask. This study aims to analyze the effect of variations in the concentration of RPPE in sleeping masks on physical characteristics and the level of preference/hedonic. RPPE concentration observed was 2.5% (F1) ; 5% (F2) ; 7.5% (F3). Characteristic tests include organoleptic, pH value, visual homogeneity, consistency and viscosity. Parameters analyzed in the hedonic test include texture, color, and aroma. The organoleptic and homogeneity were analyzed descriptively. The test data for pH and viscosity were analyzed statistically using the One Way ANOVA method. The results of the hedonic test were analyzed statistically using the Univariate method. Based on the results of the organoleptic test, it is known that F1 have a light brown color, F2 is brown, and F3 is dark brown. The third formula is visually homogeneous. The higher the concentration of RPPE, the lower the pH value and viscosity of the preparation. Increasing the concentration of RPPE reduce consistency. This study concluded that the concentration of RPPE affects the physical properties of the aspects of color, consistency, pH, and viscosity. The concentration of RPPE also affects the level of preference of the panelists. Most of the panelists prefer the color and texture of the sleeping mask that contains low concentration of RPPE (2.5%).
UJI EFEKTIVITAS EKSTRAK CIPLUKAN (PHYSALLIS ANGULATA) TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA TIKUS JANTAN GALUR WISTAR
Authors: Sari Liska Marlinda , Haty Latifah Priatni  , Azmi Darotulmutmainnah
Published: June 2023

Ciplukan chemical compounds containing flavonoids. Flavonoid act as antioxidants. The ability of flavonoids as antioxidants can reduce oxidative stress and reduce ROS (Reactive Oxygen Species). This can lead to a protective effect on beta cells of the pancreas and increases insulin sensitivity. This study aims to determine the effectiveness and on how many levels extract ciplukan (Physallis angulata) which has effectivenes on reducing blood glucose in male rats induced by alloxan. This test uses an experimental method. Statistical data processing using one-way ANOVA and t-tes. This test is performed on 18 rats were divided into 6 group negative control which was given distilled water solution, positive control group treated with a solution of metformin, the normal group was not given any treatment, and the 3 group was given the extract solution ciplukan with a dose 3mg, 6mg, dan 9mg. The results showed the existence of differences in each extract treatment provision ciplukan. Of the 3 variants dose ciplukan extract the most effective in lowering blood glucose levels in male rats that 3mg dose, but by doing so the effect can not be equated with the positive control.
GAMBARAN RASIONALITAS PENGGUNAAN OBAT DIARE PADA BALITA PENDERITA DIARE AKUT
Authors: Yuswar Muhammad Akib , Sofia Futria Wulandari  , Nera Umilia Purwanti
Published: June 2023

Diarrhea is the highest causes of death for children under five years of age in Indonesia 2019. Dehydration is one of the main causes of death in diarrhea. This study aims to find out the rationality for the use of diarrhea drugs in toddlers with acute diarrhea based on the degree of dehydration at the Sultan Syarif Mohamad Alkadrie Hospital Pontianak in 2020. The method used in this study is descriptive observational with a cross-sectional design. Data collection was carried out retrospectively, the sample was determined by purposive sampling method through searching medical record data. The results showed that the percentage rationality of using diarrhea drugs for acute watery diarrhea without dehydration based on the criteria for the right indication of (100%), the right patient of (100%), the right drug selection of (100%), the right dose of (78.57%), and the right duration of treatment of (100%); the percentage rationality of using diarrhea drugs for acute watery diarrhea with mild/moderate dehydration based on the criteria for the right indication of (100%), the right patient of (100%), the right drug selection of (62,40%), the right dose of (47.93%) and the right duration of treatment of (76.86 %) and the percentage rationality of using diarrhea drugs for acute watery diarrhea with severe dehydration based on the criteria for the right indication of (100%), right patient of (100%), the right drug selection of (90%), the right dose of (65%) and the right duration of treatment of (90%). The overall conclusion of this study is that the use of diarrhea drugs in toddlers is rational, but it needs to be considered again for drug dosing, especially in acute liquid diarrhea with mild/moderate dehydration because it has the smallest percentage of 47.93%.