bluuebunny/crossref_metadata_2025 huggingface dataset:
Prognostic value of low skeletal muscle mass in patient treated by exclusive curative radiochemotherapy for a NSCLC
Authors: Mallet R. , Decazes P. , Modzelewski R. , Lequesne J. , Vera P. , Dubray B. , Thureau S.
Published: May 2021

Low skeletal muscle mass is a well-known prognostic factor for patients treated for a non-small-cell lung cancer by surgery or chemotherapy. However, its impact in patients treated by exclusive radiochemotherapy has never been explored. Our study tries to evaluate the prognostic value of low skeletal muscle mass and other antropometric parameters on this population. Clinical, nutritional and anthropometric date were collected for 93 patients treated by radiochemotherapy for a NSCLC. Anthropometric parameters were measured on the PET/CT by two methods. The first method was a manual segmentation at level L3, used to define Muscle Body Area (MBAL3), Visceral Fat Area (VFAL3) and Subcutaneous Fat Area (SCFAL3). The second method was an software (Anthropometer3D), allowing an automatic multislice measurement of Lean Body Mass (LBMAnthro3D), Fat Body Mass (FBMAnthro3D), Muscle Body Mass (MBMAnthro3D), Visceral Fat Mass (VFMAnthro3D), and Sub-Cutaneous Fat Mass (SCFMAnthro3D) on the PET/CT. All anthropometrics parameters were normalised by the patient's height. The primary end point was overall survival time. Univariate and then stepwise multivariate cox analysis were performed for significant parameters. Finally, Spearman's correlation between MBAL3 and MBMAnthro3D was assessed. Forty-one (44%) patients had low skeletal muscle mass. The median overall survival was 18 months for low skeletal muscle mass patients versus 36 months for non-low skeletal muscle mass patients (p = 0.019). Low skeletal muscle mass (HR = 1.806, IC95% [1.09–2.98]), serums albumin level < 35 g/l (HR = 2.203 [1.19–4.09]), Buzby Index < 97.5 (HR = 2.31 [1.23–4.33]), WHO score = 0 (HR = 0.59 [0.31–0.86] and MBMAnthro3D < 8.56 kg/m2 (HR = 2.36 [1.41–3.90]) were the only significant features in univariates analysis. In the stepwise multivariate Cox analysis, only MBMAnthro3D < 8.56 kg/m2 (HR = 2.16, p = 0.003) and WHO score = 0 (HR = 0.59, p = 0.04) were significant. Finally, muscle quantified by MBAL3 and MBMAnthro3D were found to be highly correlated (Spearman = 0.9). Low skeletal muscle mass, assessed on the pre-treatment PET/CT is a powerful prognostic factor in patient treated by radiochemotherapy for a NSCLC. The automatic software Anthropometer3D can easily identify patients a risk that could benefit an adapted therapy.
RETRACTED ARTICLE: Impact of daily high dose oral vitamin D therapy on the inflammatory markers in patients with COVID 19 disease
Authors: Lakkireddy Maheshwar , Gadiga Srikanth Goud , Malathi R. D. , Karra Madhu Latha , Raju I. S. S. V. Prasad Murthy , Ragini  , Chinapaka Sangeetha , Baba K. S. S. Sai , Kandakatla Manohar
Published: May 2021

COVID 19 is known to cause immune dysregulation and vitamin D is a known immunomodulator. This study aims to objectively investigate the impact of Pulse D therapy in reducing the inflammatory markers of COVID-19. Consented COVID-19 patients with hypovitaminosis D were evaluated for inflammatory markers (N/L ratio, CRP, LDH, IL6, Ferritin) along with vitamin D on 0th day and 9th/11th day as per their respective BMI category. Subjects were randomised into VD and NVD groups. VD group received Pulse D therapy (targeted daily supplementation of 60,000 IUs of vitamin D for 8 or 10 days depending upon their BMI) in addition to the standard treatment. NVD group received standard treatment alone. Differences in the variables between the two groups were analysed for statistical significance. Eighty seven out of one hundred and thirty subjects have completed the study (VD:44, NVD:43). Vitamin D level has increased from 16 ± 6 ng/ml to 89 ± 32 ng/ml after Pulse D therapy in VD group and highly significant (p < 0.01) reduction of all the measured inflammatory markers was noted. Reduction of markers in NVD group was insignificant (p > 0.05). The difference in the reduction of markers between the groups (NVD vs VD) was highly significant (p < 0.01). Therapeutic improvement in vitamin D to 80–100 ng/ml has significantly reduced the inflammatory markers associated with COVID-19 without any side effects. Hence, adjunctive Pulse D therapy can be added safely to the existing treatment protocols of COVID-19 for improved outcomes.
Inhibitory synaptic transmission is impaired at higher extracellular Ca2+ concentrations in Scn1a+/− mouse model of Dravet syndrome
Authors: Uchino Kouya , Kawano Hiroyuki , Tanaka Yasuyoshi , Adaniya Yuna , Asahara Ai , Deshimaru Masanobu , Kubota Kaori , Watanabe Takuya , Katsurabayashi Shutaro , Iwasaki Katsunori , Hirose Shinichi
Published: May 2021

Dravet syndrome (DS) is an intractable form of childhood epilepsy that occurs in infancy. More than 80% of all patients have a heterozygous abnormality in the SCN1A gene, which encodes a subunit of Na+ channels in the brain. However, the detailed pathogenesis of DS remains unclear. This study investigated the synaptic pathogenesis of this disease in terms of excitatory/inhibitory balance using a mouse model of DS. We show that excitatory postsynaptic currents were similar between Scn1a knock-in neurons (Scn1a+/− neurons) and wild-type neurons, but inhibitory postsynaptic currents were significantly lower in Scn1a+/− neurons. Moreover, both the vesicular release probability and the number of inhibitory synapses were significantly lower in Scn1a+/− neurons compared with wild-type neurons. There was no proportional increase in inhibitory postsynaptic current amplitude in response to increased extracellular Ca2+ concentrations. Our study revealed that the number of inhibitory synapses is significantly reduced in Scn1a+/− neurons, while the sensitivity of inhibitory synapses to extracellular Ca2+ concentrations is markedly increased. These data suggest that Ca2+ tethering in inhibitory nerve terminals may be disturbed following the synaptic burst, likely leading to epileptic symptoms.
Author Correction: Efficacy and safety assessment of two enterococci phages in an in vitro biofilm wound model
Authors: Melo Luís D. R. , Ferreira R. , Costa Ana R. , Oliveira H. , Azeredo J.
Published: May 2021

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Wnt signaling in lung development, regeneration, and disease progression
Authors: Aros Cody J. , Pantoja Carla J. , Gomperts Brigitte N.
Published: May 2021

The respiratory tract is a vital, intricate system for several important biological processes including mucociliary clearance, airway conductance, and gas exchange. The Wnt signaling pathway plays several crucial and indispensable roles across lung biology in multiple contexts. This review highlights the progress made in characterizing the role of Wnt signaling across several disciplines in lung biology, including development, homeostasis, regeneration following injury, in vitro directed differentiation efforts, and disease progression. We further note uncharted directions in the field that may illuminate important biology. The discoveries made collectively advance our understanding of Wnt signaling in lung biology and have the potential to inform therapeutic advancements for lung diseases.
Inhibition of the Ras/ERK1/2 pathway contributes to the protective effect of ginsenoside Re against intimal hyperplasia
Authors: Gao Chenying , Zhang Kaina , Liang Fanfan , Ma Wenzhuo , Jiang Xixi , Wang Hongying , Zhan Heqin , Sonkoly Enikö , Hu Hao , Zhao Zhenghang
Published: May 2021

Re was shown to inhibit vascular injury-induced neointimal thickening probably by promoting VSMC apoptosis and inhibiting autophagy via suppression of the Ras/MEK/ERK1/2 signalling pathway.
Different effects of soybean protein and its derived peptides on the growth and metabolism of Bifidobacterium animalis subsp. animalis JCM 1190
Authors: Li Wenhui , Li He , Zhang Yinxiao , He Lijuan , Zhang Chi , Liu Xinqi
Published: May 2021

Digested soybean peptides promoted the growth and metabolism of Bifidobacterium animalis subsp. animalis JCM 1190 and balanced the ability of Bifidobacterium animalis subsp. animalis JCM 1190 and Escherichia coli JCM 1649 to utilize nitrogen sources.
Synthesis of 2-alkyl-chroman-4-ones via cascade alkylation–dechlorination of 3-chlorochromones
Authors: Li Shunyao , Zhang Lanfei , He Qian , Zhang Xiaofei , Yang Chunhao
Published: May 2021

An efficient and mild synthetic approach for 2-alkyl-substituted chroman-4-ones via zinc mediated cascade decarboxylative β-alkylation and dechlorination of 3-chlorochromones was developed.
Recent progress towards the transition-metal-catalyzed Nazarov cyclization of alkynes via metal carbenes
Authors: Ru Guang-Xin , Zhang Ting-Ting , Zhang Meng , Jiang Xiao-Lei , Wan Zheng-Kai , Zhu Xiu-Hong , Shen Wen-Bo , Gao Guang-Qin
Published: May 2021

This review is to highlight the recent progresses in the transition-metal-catalyzed Nazarov cyclization of alkynes via metal carbenes, such as α-oxo metal carbene, α-imino metal carbene, α-phenyl metal carbene and α-cyclopropyl metal carbene.
Carbon dioxide based methodologies for the synthesis of fine chemicals
Authors: Sable Dhanashri A. , Vadagaonkar Kamlesh S. , Kapdi Anant R. , Bhanage Bhalchandra M.
Published: May 2021

Rapid environmental changes triggered by the increase in the concentration of heat-absorbing gases such as CO2 in the atmosphere have become a major cause of concern.
Convenient semihydrogenation of azoarenes to hydrazoarenes using H2
Authors: Sahoo Manoj K. , Sivakumar Ganesan , Jadhav Sanjay , Shaikh Samrin , Balaraman Ekambaram
Published: May 2021

Convenient and highly selective hydrogenation reaction of azoarenes using molecular hydrogen to access diverse hydrazoarenes is reported.
J-aggregation induced emission enhancement of BODIPY dyes via H-bonding directed supramolecular polymerization: the importance of substituents at boron
Authors: Zhang Yongjie , Yuan Siyuan , Liu Ping , Jing Lei , Pan Hongfei , Ren Xiang-Kui , Chen Zhijian
Published: May 2021

For uracil-functionalized BODIPY dyes 1a–c, AIEE upon H-bonding directed J-aggregation was observed for the two dyes bearing alkyne groups at boron while the BF2-chelated dye displayed ACQ, indicating the crucial role of the substituents at boron.
Sabina chinensis leaf extracted and in situ incorporated polycaprolactone/polyvinylpyrrolidone electrospun microfibers for antibacterial application
Authors: Ge Yan , Tang Jiapeng , Ullah Azeem , Ullah Sana , Sarwar Muhammad Nauman , Kim Ick-Soo
Published: May 2021

Sabina chinensis is a valuable reforestation conifer and traditional medicinal plant.
Studies on a glutathione coated hollow ZnO modified glassy carbon electrode; a novel Pb(ii) selective electrochemical sensor
Authors: Malik Lateef Ahmad , Pandith Altaf Hussain , Bashir Arshid , Qureashi Aaliya , Manzoor Taniya
Published: May 2021

Decrease in the band gap of the "Composite-Metal" systems in comparison to pure composite is a key factor in the electrochemical detection of heavy metal ions such as Pb(ii), Cd(ii) and Hg(ii) ions while using glutathione coated hollow ZnO modified glassy carbon electrode (Glu-h-ZnO/GCE).
Unsymmetrical pentamethine cyanines for visualizing physiological acidities from the whole-animal to the cellular scale with pH-responsive deep-red fluorescence
Authors: Wang Yicheng , Lei Zuhai , Wang Cong , Cao Chong , Hu Jiayi , Du Ling , Han Limei , Li Cong
Published: May 2021

Unsymmetrical pentamethine cyanine fluorophores were developed and used to visualize physiological acidities from the whole-animal to the cellular scale with pH-responsive deep-red fluorescence.
Iron-catalyzed one-pot synthesis of quinoxalines: transfer hydrogenative condensation of 2-nitroanilines with vicinal diols
Authors: Putta Ramachandra Reddy , Chun Simin , Lee Seok Beom , Hong Junhwa , Oh Dong-Chan , Hong Suckchang
Published: May 2021

A transfer hydrogenative condensation between 2-nitroanilines and vicinal diols for the synthesis of quinoxalines, with no additional oxidant, reductant and base.
Electrochemical reduction of carbon dioxide (CO2): bismuth-based electrocatalysts
Authors: Guan Yayu , Liu Minmin , Rao Xufeng , Liu Yuyu , Zhang Jiujun
Published: May 2021

Bi-based catalysts for electrochemical reduction of CO2(ERCO2), including their preparation, electrochemical performance, reaction mechanisms and further challenges and research directions.
Recent advances in g-C3N4-based photocatalysts incorporated by MXenes and their derivatives
Authors: Hou Huilin , Shao Gang , Yang Weiyou
Published: May 2021

An overview of the recent advances in g-C3N4-based photocatalysts incorporated by MXenes and their derivatives is provided and discussed systematically.
Electrochemical integration of amorphous NiFe (oxy)hydroxides on surface-activated carbon fibers for high-efficiency oxygen evolution in alkaline anion exchange membrane water electrolysis
Authors: Thangavel Pandiarajan , Kim Guntae , Kim Kwang S.
Published: May 2021

Designing a high-efficiency and low-cost three-dimensional (3D) OER electrode via electrochemical integration of amorphous NiFeOOH on surface activated carbon fibers.
Use of organic bulk-heterojunction solar cells as selective contacts in wide band-gap perovskite solar cells: advantages and limitations
Authors: Su Lijun , Màlaga Maria Méndez , Zhu Miaoli , Xiao Yaoming , Gil Emilio Palomares
Published: May 2021

In this work, we demonstrate that modifying the I/Br ratio in perovskite composition, the OPV layer in integrated perovskite/OPV (BHJ) system shows different functionality–hole transporting layer or independent solar cell.
Target-triggered and controlled release plasmon-enhanced fluorescent AIE probe for conformational monitoring of insulin fibrillation
Authors: Jia Yijing , Guo Shaoshi , Han Qingzhi , Zhu Jiale , Zhang Xinlian , Na Na , Ouyang Jin
Published: May 2021

The PEF-AIE sensor of a target-triggered and controlled release system is proposed, realizing the monitoring of conformational changes in the amyloid fibrillation process with insulin as a model.
Recent advances in the development of nitric oxide-releasing biomaterials and their application potentials in chronic wound healing
Authors: Wu Min , Lu Zhihui , Wu Keke , Nam Changwoo , Zhang Lin , Guo Jinshan
Published: May 2021

This paper reviews the recent progress in nitric oxide (NO) donors, biomaterial vectors, biomaterial-based NO delivery systems and NO synthetic enzyme mimics, and emphasizes the application potentials of NO releasing biomaterials in chronic wound healing.
Correction: Co-delivery of anionic epitope/CpG vaccine and IDO inhibitor by self-assembled cationic liposomes for combination melanoma immunotherapy
Authors: Su Qi , Wang Changrong , Song Huijuan , Zhang Chuangnian , Liu Jinjian , Huang Pingsheng , Zhang Yumin , Zhang Jianhua , Wang Weiwei
Published: May 2021

Correction for ‘Co-delivery of anionic epitope/CpG vaccine and IDO inhibitor by self-assembled cationic liposomes for combination melanoma immunotherapy’ by Qi Su et al., J. Mater. Chem. B, 2021, 9, 3892–3899, DOI: 10.1039/d1tb00256b.
Correction: Recent advances in cell membrane coated metal–organic frameworks (MOFs) for tumor therapy
Authors: Liu Weicong , Yan Qianwen , Xia Chen , Wang Xiaoxiong , Kumar Abhinav , Wang Yan , Liu Yiwei , Pan Ying , Liu Jianqiang
Published: May 2021

Correction for ‘Recent advances in cell membrane coated metal–organic frameworks (MOFs) for tumor therapy’ by Weicong Liu et al., J. Mater. Chem. B, 2021, DOI: 10.1039/d1tb00453k.
Suppressed energy transfer between different rare earth ions to obtain enhanced and tuned fluorescence by using Janus nanofibers
Authors: Wu Ping , Ma Qianli , Yu Wensheng , Wang Jinxian , Liu Guixia , Dong Xiangting
Published: May 2021

Different rare earth ions can be microcosmically separated in Janus nanofibers, so that the energy transfer between different rare earth ions can be markedly suppressed and the negative effects resulting from the energy transfer can be effectively reduced.
Design of broadband near-infrared Y0.57La0.72Sc2.71(BO3)4:Cr3+ phosphors based on one-site occupation and their application in NIR light-emitting diodes
Authors: Wu Haiyan , Jiang Lihong , Li Kai , Li Chengyu , Zhang Hongjie
Published: May 2021

A novel broadband near-infrared Y0.57La0.72Sc2.71(BO3)4:Cr3+ phosphor based on one-site occupation was designed by introducing a distorted octahedral structure.
Correction: Three-dimensional/two-dimensional photonic crystal hydrogels for biosensing
Authors: Shen Peiyan , Zhang Yuqi , Cai Zhongyu , Liu Ruixiang , Xu Xiaoying , Li Ran , Wang Ji-Jiang , Yang De’an
Published: May 2021

Correction for ‘Three-dimensional/two-dimensional photonic crystal hydrogels for biosensing’ by Peiyan Shen et al., J. Mater. Chem. C, 2021, 9, 5840–5857, DOI: 10.1039/D1TC00830G.
Notch–Rho–cGMP interaction: common point of convergence in microvascular aging-related disease
Authors: Roks Anton J.M. , Cheng Caroline , Shanahan Catherine M.
Published: May 2021

Vascular smooth muscle biology is increasingly exploited as an interventional target in vascular disease. Vascular smooth muscle Notch3–Rho kinase–cGMP interaction has been implicated in brain and peripheral arteriopathy in CADASIL. In the present commentary, we discuss the potential implications for other, more common non-atherosclerotic microvascular diseases: INOCA and HFpEF. The relation to mechanotransduction, to cellular senescence and to sGC activators as potential intervention agents are described.
Comprehensive platform for distribution transactive energy markets
Authors: Sabillon Carlos , Mohamed Amr A. , Golriz Ali , Venkatesh Bala
Published: May 2021

Reducing the cost of distributed energy resources (DERs) such as renewables, storage, electric vehicles and smart loads is driving their increased connection to distribution systems. Extracting maximum benefits from DERs require liberalising distribution systems by allowing: (1) a distribution transactive energy market (DTEM) operated by a local distribution operator (LDO) and (2) peer‐to‐peer (P2P), peer‐to‐LDO (P2LDO) and Transmission‐to‐LDO (T2LDO) type transactions. A DTEM will bring several benefits such as: (1) enhanced economic opportunity for DERs, making them more profitable and (2) increased social welfare benefiting both buyers and sellers. To achieve this objective, we develop a comprehensive three‐phase DTEM platform that provides maximum economic opportunities for DERs and maximises social welfare that benefits all market participants, while considering P2P, P2LDO and T2LDO transactions, for both energy and ancillary services. Interaction between bulk electricity market independent system operator (ISO) and LDO controlled DTEM is presented. The DTEM model is implemented as a practical mixed‐integer linear programming formulation that includes a network reconfiguration feature. The DTEM model is studied on three‐phase 5‐bus and 34‐bus systems, demonstrating its effectiveness to settle energy and ancillary service transactions, while obtaining distribution locational marginal prices. Results show that P2P transactions, when allowed, increase social welfare and increases profitability of DERs.
Optimal short‐circuit current control of the grid‐forming converter during grid fault condition
Authors: Liu Chang , Cai Xu , Li Rui , Yang Renxin
Published: May 2021

A considerable amount of rotating synchronous machines are being replaced by the increasing capacity of converter‐based resources, which has stimulated a demand for grid‐forming converters (GFCs) for grid supporting. The inertia and frequency responses of GFC are remarkably similar to those of synchronous generator (SG), but the inadequate capability of sourcing short‐circuit current of GFCs during grid fault can lead to several serious consequences. The low short‐circuit current level fails to trigger protection relays and cannot provide sustained voltage support during the fault or more effectively support the recovery of voltage after fault clearance. The short‐term overcurrent capability of GFC can be promoted either from the point of view of the power devices or from the topology of it. The overcurrent capability of converter is hard‐earned, so full use of it should be made. This paper proposes an optimal control strategy of short‐circuit current of GFC, which can enable the GFC to source the short‐circuit current with an optimal angle within the allowable magnitude. A detailed simulation model of the proposed method here is set up in PSCAD/EMTDC. The simulation results show that the proposed method can achieve better voltage supporting results compared with the traditional reactive support control.
A survey on blockchain‐enabled smart grids: Advances, applications and challenges
Authors: Liu Chao , Zhang Xiaoshuai , Chai Kok Koeng , Loo Jonathan , Chen Yue
Published: May 2021

Electric power grid infrastructure has revolutionized our world and changed the way of living. So has blockchain technology. The hierarchical electric power grid has been shifting from a centralized structure to a decentralized structure to achieve higher flexibility and stability, and blockchain technology has been widely adopted in the energy sector to deal with grid management, billing, metering, and so on, because of its nature of decentralization. Here, the aim is to provide a multi‐dimensional review on the technological advances of the blockchain in smart grids. Its corresponding applications based on these advances, including company projects and use cases, are summarized. Furthermore, the security threat issues in smart grids, Ethereum Virtual Machine (i.e. the operating environment of consensus mechanisms), and smart contracts are analysed, with a brief conclusion to manifest the prior tasks in building secure blockchain‐based infrastructures in smart grids. As such, the challenges and features of different protocols and their applicability in each use case are identified to provide an insightful guide for future research studies.
SRoll3: A neural network approach to reduce large-scale systematic effects in the Planck High-Frequency Instrument maps
Authors: Lopez-Radcenco M. , Delouis J.-M. , Vibert L.
Published: May 2021

In the present work, we propose a neural-network-based data-inversion approach to reduce structured contamination sources, with a particular focus on the mapmaking for Planck High Frequency Instrument data and the removal of large-scale systematic effects within the produced sky maps. The removal of contamination sources is made possible by the structured nature of these sources, which is characterized by local spatiotemporal interactions producing couplings between different spatiotemporal scales. We focus on exploring neural networks as a means of exploiting these couplings to learn optimal low-dimensional representations, which are optimized with respect to the contamination-source-removal and mapmaking objectives, to achieve robust and effective data inversion. We develop multiple variants of the proposed approach, and consider the inclusion of physics-informed constraints and transfer-learning techniques. Additionally, we focus on exploiting data-augmentation techniques to integrate expert knowledge into an otherwise unsupervised network-training approach. We validate the proposed method on Planck High Frequency Instrument 545 GHz Far Side Lobe simulation data, considering ideal and nonideal cases involving partial, gap-filled, and inconsistent datasets, and demonstrate the potential of the neural-network-based dimensionality reduction to accurately model and remove large-scale systematic effects. We also present an application to real Planck High Frequency Instrument 857 GHz data, which illustrates the relevance of the proposed method to accurately model and capture structured contamination sources, with reported gains of up to one order of magnitude in terms of performance in contamination removal. Importantly, the methods developed in this work are to be integrated in a new version of the SRoll algorithm (SRoll3), and here we describe SRoll3 857 GHz detector maps that were released to the community.
The MUSE-Faint survey
Authors: Zoutendijk Sebastiaan L. , Brinchmann Jarle , Bouché Nicolas F. , den Brok Mark , Krajnović Davor , Kuijken Konrad , Maseda Michael V. , Schaye Joop
Published: May 2021

Aims. We use stellar line-of-sight velocities to constrain the dark-matter density profile of Eridanus 2, an ultra-faint dwarf galaxy with an absolute V-band magnitude MV = −7.1 that corresponds to a stellar mass M* ≈ 9 × 104 M⊙. We furthermore derive constraints on fundamental properties of self-interacting and fuzzy dark matter scenarios.

Methods. We present new observations of Eridanus 2 from MUSE-Faint, a survey of ultra-faint dwarf galaxies with the Multi Unit Spectroscopic Explorer on the Very Large Telescope, and determine line-of-sight velocities for stars inside the half-light radius. Combined with literature data, we have 92 stellar tracers out to twice the half-light radius. With these tracers we constrain models of cold dark matter, self-interacting dark matter, and fuzzy dark matter, using CJAM and pyGravSphere for the dynamical analysis. The models of self-interacting and fuzzy dark matter relate the density profile to the self-interaction coefficient and the dark-matter particle mass, respectively.

Results. We find substantial evidence (Bayes factor ∼10−0.6) for cold dark matter (a cuspy halo) over self-interacting dark matter (a cored halo) and weak evidence (Bayes factor ∼10−0.4) for fuzzy dark matter over cold dark matter. We find a virial mass M200 ∼ 108 M⊙ and astrophysical factors J(αcJ) ~ 1011 M⊙2 kpc−5 and D(αcD) ~ 102 − 102.5 M⊙ kpc−2 (proportional to dark-matter annihilation and decay signals, respectively), the exact values of which depend on the density profile model. The mass-to-light ratio within the half-light radius is consistent with the literature. We do not resolve a core (rc < 47 pc, 68% confidence level) or a soliton (rsol < 7.2 pc, 68% confidence level). These limits are equivalent to an effective self-interaction coefficient fΓ < 2.2 × 10−29 cm3 s−1 eV−1 c2 and a fuzzy-dark-matter particle mass ma > 4.0 × 10−20 eV c−2. The constraint on self-interaction is complementary to those from gamma-ray searches. The constraint on fuzzy-dark-matter particle mass is inconsistent with those obtained for larger dwarf galaxies, suggesting that the flattened density profiles of those galaxies are not caused by fuzzy dark matter.
Effect of solar wind density and velocity on the subsolar standoff distance of the Martian magnetic pileup boundary
Authors: Wang M. , Lee L. C. , Xie L. , Xu X. , Lu J. Y. , Kabin K. , Wang J. , Li L. , Sui H. Y.
Published: May 2021

Using a 3D multispecies magnetohydrodynamic model, we investigated the effect of the solar wind dynamic pressure (Pd) with different densities and velocities on the subsolar standoff distance (r0) of the Martian magnetic pileup boundary (MPB). We fixed the solar maximum condition, the strongest crustal field located in the dayside region, and the Parker spiral interplanetary magnetic field at Mars. We simulated 35 cases with a Pd range of 0.1494 to 7.323 nPa (solar wind number density n ∈ [1, 9] cm−3, and solar wind velocity V ∈ [−258, −1344] km s−1). The main results are as follows. (1) r0 decreases with increasing Pd according to the power-law relations. For the same Pd, a higher solar wind velocity (lower density) results in a larger r0 of the Martian MPB. (2) A higher solar wind density leads to a lower ratio of the compressed magnetic field strength to the crustal field strength and a larger plasma β under the same Pd. This indicates that the thermal pressure at the Martian MPB plays a significant role for the compressed magnetic field. Because the magnetic pileup process is stronger for a higher solar wind velocity, the magnetic pressure at the Martian MPB is increased. As a result, the thermal pressure decreases and r0 of the Martian MPB increases. (3) We present a new formula of r0 with the parameters of the solar wind dynamic pressure, number density, and velocity.
Seaport development management based on business process modeling
Authors: Bagirov Etibar , Pantina Tatiana , Borodulina Svetlana
Published: May 2021

Increasing the production capacity of ports is seen as one of the most significant goals for the development of maritime transport infrastructure, which requires the use of adequate forecasting methods. The problem of choosing methods of management in transport in conditions of instability of cargo flows, non-stationary functioning, the need for digitalization and transformation of processes and technologies is of particular importance. Taking advantage of the process approach in the management of seaport development, such as flexibility and transparency, is becoming an effective way to increase the productivity and efficiency of maritime transport in general. The paper presents the author’s presentation of the peculiarities of the process management of the seaport development. The use of the concept of modularity in managing the development of a seaport through a system of business processes is proposed. A method for assessing the significance of the seaport business processes for achieving its goals from the standpoint of their further optimization is presented. The research results presented in the paper were obtained on the basis of the description and economic and mathematical modeling of the basic business processes that form the process outputs. Using the seaport of Baku as the example, predictive models of cargo flows are described.
Modern problems in assessment of hydraulic resistance
Authors: Sikarev Igor , Vekshina Tatiana , Bolshakov Vladimir , Korinets Ekaterina , Butsanets Artem
Published: May 2021

The paper is devoted to the analysis of modern problems in assessment of hydraulic resistance. The obtained formulas for calculating the roughness coefficients and other interrelated hydraulic parameters of the channel are given. As a determining factor for the systemic characteristics of flows, N.A. Rzhanitsyn used the average long-term and average maximum water discharges, and the authors of this work proposed the use of these characteristics in accordance with the watershed area A in km2 of the subsequently derived dependences for unexplored rivers. Thanks to this approach, it became possible to obtain information by cartographic methods. Direct approximation of these data gives an expression for the flow order. The formulas obtained can be used to calculate the hydraulic characteristics of lowland rivers. For the European territory of Russia, the formulas have been tested using independent field information. However, the authors believe that the formulas will successfully work for other even lands as well. The formulas are simple and easy to calculate using software. In the future, it is planned to use specialized software for processing calculations and use the obtained results in the geographic information system.
Classification of parameters of innovative projects in the framework of digital transformation programs for sustainable development of industrial enterprises
Authors: Kozlov Aleksandr , Pavlova Elizaveta , Królas Pawel
Published: May 2021

The task of determining the parameters of an innovative project, their composition and structure is a crucial stage in the design and development of an innovative project within the framework of digital transformation. A refined classification of the parameters of an innovative project, considering the specifics of projects aimed at digital transformation of the enterprises, operating in the manufacturing sector, is proposed. The classification separates the parameters of innovative projects into 2 key categories: target parameters and controlled or limiting parameters. When applied to innovative project parameters in digital transformation, target parameters are further divided into gradual and optional types; controlled or limiting parameters constitute basic structure of innovative projects and include road-map and time allocation, costs, market parameters, human resources, technological readiness, regulatory norms. The presented approach leaves room for further research based on additional real case data and risk evaluation, standard and accepted deviations of the project results analysis.
The analysis of digitalization impact on personnel functions in logistics
Authors: Bavrin Aleksandr , Koop Violetta , Lukashevich Nikita , Simakova Zoya , Temirgaliev Egor
Published: May 2021

The article discusses the main types of employment in logistics. The functionality of positions in purchasing, warehousing, transport and information logistics, as well as in external economic activities, is analyzed in sufficient detail. The following positions are considered: purchasing agent, railway transport service agent, car driver, dispatcher, vehicle maintenance engineer, transport organization and management engineer, logist, logistician, foreign economic activity Manager, air transportation Manager, purchasing Manager, logistics Manager, customs Manager, warehouse Manager, operational logistician, vehicle auditor, marine transportation specialist, customs broker, transport planner, freighter, freight forwarder, freight forwarding agent, specialist in the field of digital logistics, specialist of the Contract service. Digitalization is capable of influencing the job responsibilities of logistics personnel in the fact that over time the need for human personnel decreases. In this regard, there is a need to be able to identify such functions that can be replaced by information or automated systems. The main aspects of the impact of digitalization on logistics are indicated: transport logistics, purchasing logistics, information logistics, customs logistics.
High-speed aboveground transport - a new impetus for sustainable economic development
Authors: Grigoriev Evgeny , Arkhipov Anatoly
Published: May 2021

Transport is a system-forming branch of the national economy, ensuring the territorial integrity and unity of the economic space. The development of economic processes, increasing competition and the increasing impact of economic ties, include the issues of improving the transport system among the priorities. The article analyzes the problems of modern transport systems, identifies the shortcomings of traditional modes of transport and the main directions of their development. The directions of innovative development of the transport system of Russia are analyzed. The review of innovative developments of high-speed transport, which allows to increase the integration potential of the regions and the mobility of the population, to reduce social tensions in remote regions from the central part of the country, to ensure the economic security of the country. Conclusions are drawn about the current state of implementation of such systems and prospects for application in Russia. The requirements for the new generation transport system are defined.
Effect of fertilizer application on the ‘Bukhara-102’ variety of cotton yield in salt-affected cotton fields of Uzbekistan
Authors: Isaev S , Rajabov T , Goziev G , Khojasov A
Published: May 2021

In this article, stratified feeding of Bukhara-102 variety of medium-fiber cotton with mineral fertilizers were carried out in the conditions of irrigated and fertile soils of Kashkadarya province. Simultaneously, compared to the studied fertilizer application options, there was a decrease in soil volume by 0.01–0.02 g/cm3, an increase in soil porosity by 0.4–1.2%, and an increase in soil water permeability to 5.8–24.6 m3/ha. Moreover, an additional yield of 1.3–2.6 quintals of cotton, the quality indicators of fiber length that increased by 0.1–0.2%, fiber yield to 0.2–0.5%, the weight of 1, 000 seeds to 1–2 grams , the incidence of Wilt's disease was found to become as low as 6.1–10 %. At the same time, with increasing salinity in the care of saline soils at different levels, the net profit was around 40, 617 - 1, 127, 853 UZS and the profitability rate was 0.8-20.1% lower than expected.
Automation of intraoperative analysis of indicators the inflammatory response of neurosurgical patients undergoing brain tumors removal
Authors: Sokolov Sergey , Kondratiev Anatoliy , Lesteva Nataliya , Dragina Nataliya
Published: May 2021

The data of the study of indicators of the inflammatory response, hormonal status, biochemical blood parameters in the perioperative period in neurosurgical patients undergoing surgery for tumors of the posterior cranial fossa are presented. This study included 65 patients. The surgery was performed under anesthesia with fentanyl (3-5 µg / kg-hour), clonidine (1-2 µg / kg-hour), and propofol (3-5 mg / kg-hour). A significant increase in the level of interleukin 10 was observed at the level of hemostasis. The day after surgery, the level of Interleukin 6 increased significantly. During hemostasis, there was a temporary increase in ACTH, cortisol, and prolactin levels. The day after the surgery, rates returned to their original levels. Under conditions of persistent neurovegetative, a sufficient humoral response to surgical trauma was noted.
Nosematosis of white silkworm and measures to combat with it
Authors: Ismatullaeva D.A , Ruzmatov Sh
Published: May 2021

This article presents the results of studies on the treatment of silkworm grena, slightly infected with nosematosis. As a result of treatment of grena with antibiotics and their combinations, a significant increase in the revitalization of grena and a decrease in the extensiveness of infection with nosematosis of revitalizing caterpillars is observed. It has been established that antibiotic chemicals, especially in combinations, contribute to the disinfection of grains from infectious diseases, in particular from nosematosis, and thereby improve the quality of silkworm grains. Which, in turn, helps to prevent the occurrence of diseases on the pedigree and industrial feedings of the silkworm
Influence of raw roller density of saw fiber separator on productivity and fiber quality
Authors: Safarov A. A. , Narmatov E. A. , Safar S. , Qozoqboyev U. , Bakhriddinov A.
Published: May 2021

This article determines the possibility of ejaculation of bare seeds from the working chamber of the genie using auxiliary ejaculatory devices. Based on theoretical and experimental studies, results were obtained to improve the quality of fiber, seeds and gin productivity in the allocation of bare seeds from the working chamber. Based on the results of a full-factor experiment, graphs were constructed of the time spent on exposed seeds on gin productivity, the number of revolutions of vas differencing devices and the number of exposed seeds.
Pests of rice agrobiocenosis type of structure
Authors: Otamirzaev N G , Ibodullaeva R
Published: May 2021

The article identified 10 species of pests that damage rice plants during the season in rice agrobiocenosis. Leptestheria dahalacensis Sars, Apus concriformis Sh., Ostrinia nubilalis Hb, and Cephus pygmaeus have been reported to cause damage to rice grasses. A growth calendar has been developed. In the pest experiment during the rice germination period, Nurell D was found to contain 55% em.k. (Cypermethrin + chlorpriphos) - in the variant applied to 1.5 l/ha, the biological effectiveness of the drug is the highest for 14 days - 93.9%, in the variant treated with Tayshin 500 s.d.g (Clothianidin) -0.06 kg/ha for 14 days - 93.3%. In the experiment, the main pest Nurell D in the variant using 55% (1.5 l/ha) was 73.8 quintals of Iskandar variety, ie 13.2 quintals per hectare compared to the control, the new chemical Taishin 500 s.d.g. (0.06kg/ha) yielded 70.7 q/ha in the variant in which the chemical agent was used, and 10.1 additional yields were reported.
Economic and social benefits of a strategy of ecological monitoring for oil and gas companies operating in the Russian Arctic
Authors: Bianco Ishel , Illinskyi Alexander , Fadeev Alexey
Published: May 2021

Ecological monitoring provides a more complete picture of the possible effects of extractive activities for oil and Gas companies operating in the Russian Arctic and in other ecological sensitive areas. This paper proposes a framework to evaluate the adequacies of different monitoring systems for Operations in the Arctic for oil and Gas companies. Our research also demonstrates how Ecological monitoring could be a useful strategic tool for long term risk reduction, accident avoidance and to improve the socio-economic development for indigenous communities.
Development of state ideology as a basis for improving the executive power
Authors: Goncharov Vitaly , Mikhaleva Tatiana , Vasilevich Grigory , Balashenko Sergey , Zalesny Jacek , Pukhov Artem
Published: May 2021

This article provides a constitutional and legal analysis of the problems of the formation and development of state ideology as the basis for optimizing the system of executive power in the Russian Federation. According to the authors, without the formation of a state ideology in the Russian Federation, it is impossible to ensure the development of society and the state. The work has developed and justified a system of measures to remove obstacles in the formation and development of state ideology in Russia; the purposes, tasks and parameters of the ideological basis of Russian statehood are formulated, which will ensure the implementation of the optimization of the executive power system in the country, the large-scale modernization of its economy and the qualitative improvement of the living standards of the population of the Russian Federation.
Employee involvement in reducing alienation in Russian environmental corporations
Authors: Kozlova Elena
Published: May 2021

Sustainable development, encompassing environmental, social responsibility, and corporate governance issues, is a crucial development concept for many global companies. Foreign companies have long appreciated the positive economic effect of following these principles, which consists of an increase in key indicators and a decrease in staff turnover. Russian companies still consider sustainable development activities an optional element of doing business and do not expect additional economic benefits. Current economic conditions are characterized by high uncertainty and dynamism, which forces companies to look for new ways to improve business efficiency. In Russian companies, one of these ways may be to reduce employees’ degree of alienation and increase employee engagement. Based on the survey results, the article analyzes the social and personal factors that affect the degree of alienation of employees of Russian enterprises. It is proposed to consider increasing employees’ engagement as an effective mechanism for reducing the level of alienation. The practice of assessing employee engagement in Russian companies is considered.
Cryptocurrency as a factor for National Payment System Improvement in the process of Economy’s digitalization
Authors: Sorokina Oksana , Dudukalov Egor , Guzikova Liudmila , Ushakov Denis
Published: May 2021

Research develops the modern theory and methodology of cryptocurrency functioning as an integral part of modern money circulation, and the main directions of cryptocurrency progress as means of legal payment in the Republic of Indonesia. Based on the econometric model of the cryptocurrency main indicators influence the relationship between “bitcoin” attributes was assessed; the probable scenarios for the financial regulation system of the Republic of Indonesia (RI) effectivization based on the National Bank or special financial institutions competences were highlighted; the practical recommendations aimed at combating money laundering in cryptocurrency-based transactions have been developed from the position of priority for Indonesian payment system modernization.
Some global economic realities and environmental impact in the context of the pandemic: causes and trends
Authors: Sakhbieva Amina , Goncharov Vitaly , Zatsarinnaya Elena , Gordeeva Daria , Kalyakina Inessa , Ignatyeva Olga
Published: May 2021

The article examines some of the world’s economic realities in the context of a pandemic. It is noted that the world will experience the economic consequences of the pandemic for several more years. Well-established supply chains have been disrupted, some cranes have fallen into deep recessions, and the recovery of some of the world’s leading economic sectors is still in doubt. No one could have imagined that such a large industry as the oil industry, in the literal sense, will go into negative territory, and the air carriers will remain practically out of work. However, this took place in real life and was reflected in economic history. Therefore, in order to overcome these negative trends in the future, it is necessary to learn from the mistakes of today, this will make it possible to prevent the shutdown of economically important industries in the future and allow the economy to develop, even if not at a high pace, but still within the framework of a certain progressive development.The purpose of the work is to analyze some of the economic events that took place during the pandemic in order to identify the causes of their occurrence and further development trends.
The effect of socio-cultural factors on the international flight safety research findings
Authors: Matyukhina Oleksandra , Ordenov Sergii , Poda Tetiana , Sukhova Nadiia
Published: May 2021

Nowadays we can get anywhere in the world. The success of civil aviation became possible thanks to flight safety improvement. However, flight safety performance indicators are still low. This is because the ensuring flight safety is largely due to the peculiarities of the impact of socio-cultural factors in different regions. The article is noted that flights are performed by humans with the help of technical means, but it is important to establish anthropological and socio-cultural factors that influence human decision-making. But during the process of communication between the representatives of technocratic and traditionalist societies, misunderstandings, differences of interpretations keep arising. These differences in interpretations are the result of socio-cultural differences. In a traditionalist society; the priority of the senior in status has an unconditional priority over the impersonal universalism of the instructions and norms. From the standpoint of technocratic thinking, the requirements of mechanisms, technical systems and norms have unconditional priority over human orders. But from the standpoint of the traditionalist world view the system of interpersonal relations the dominant are the attitudes and demands of the person, senior in status. Independent, analytical thinking can free a person from the unconditional recognition of the authority of the senior in status.
Mongolian democracy: key challenges and opportunities in modern environment
Authors: Oidov Khatanbold
Published: May 2021

In the last three decades, views about democracy in Mongolia have transformed from high expectations and hopes to perceived failure in performances in political and economic terms. A national and international researchers concluded that at the initial stage of democratization, Mongolians were guided by the general concepts and values of democracy such as human rights, liberty, and freedom of association and expression. Later, these values shifted to more in-depth notions that can be summarized as “democracy is a process for ensuring accountability and justice based on the active engagement of citizens”. This article explores the factors that contributed to democratic challenges and bottlenecks drawing on experts’ interviews conducted by the author and a review of various public opinion surveys assessing democratic performance in Mongolia. The article uses methodologies and tools designed by International IDEA and assesses the applicability of different democratic models to the Mongolian context. It argues that the evaluation of democracy in Mongolia should use additional criteria reflecting Mongolian characteristics. It concludes by suggesting that the enhancement of the democratic mechanism of accountability of public institutions is a key opportunity to consolidate democracy. The experts participating in the assessment viewed the frameworks of executive, pluralist and protective democracy are more suitable for democracy development in Mongolia, and communitarian democracy.