bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhancing Signature Verification Using Triplet Siamese Similarity Networks in Digital Documents
Authors: Tehsin Sara , Hassan Ali , Riaz Farhan , Nasir Inzamam Mashood , Fitriyani Norma Latif , Syafrudin Muhammad
Published: September 2024

In contexts requiring user authentication, such as financial, legal, and administrative systems, signature verification emerges as a pivotal biometric method. Specifically, handwritten signature verification stands out prominently for document authentication. Despite the effectiveness of triplet loss similarity networks in extracting and comparing signatures with forged samples, conventional deep learning models often inadequately capture individual writing styles, resulting in suboptimal performance. Addressing this limitation, our study employs a triplet loss Siamese similarity network for offline signature verification, irrespective of the author. Through experimentation on five publicly available signature datasets—4NSigComp2012, SigComp2011, 4NSigComp2010, and BHsig260—various distance measure techniques alongside the triplet Siamese Similarity Network (tSSN) were evaluated. Our findings underscore the superiority of the tSSN approach, particularly when coupled with the Manhattan distance measure, in achieving enhanced verification accuracy, thereby demonstrating its efficacy in scenarios characterized by close signature similarity.
Does Monopolar Electrocautery Affect the Fetus during Cesarean Section?
Authors: Gokulu Sevki Goksun , Yildiz Hamza , Yildizbakan Ali , Ulger Gorkem , Durukan Huseyin , Celik Yalcin , Aytan Hakan
Published: September 2024

Background and Objectives: This study aimed to assess the impact of monopolar electrocautery on the fetus during cesarean section. Materials and methods: A retrospective analysis was conducted with 552 patients delivered by cesarean section. Patients were grouped based on usage of monopolar electrocautery. In 272 patients, monopolar electrocautery was used to separate the tissues before the delivery. In 280 patients, no electrocautery was used. Newborn vital signs, Apgar scores, umbilical cord blood parameters, newborn serum parameters collected within 6th postpartum hour, and rate of newborn intensive care unit admission were compared. Results: The 1st and 5th minute Apgar scores were significantly higher in the electrocautery group; however, this difference lost its significance at the 10th minute. The median newborn pulse rate (148 (7) vs. 146 (6) beats per minute, p = 0.026), umbilical cord blood pH, and partial oxygen pressure were significantly higher in the electrocautery group compared to the no-electrocautery group (7.34 ± 0.06 vs. 7.31 ± 0.06, p < 0.001, and 25.5 (14.77) vs. 23 (16.08) mmHg, p = 0.025, respectively). The median umbilical cord blood serum calcium level was 1.51 (0.64) mmol/L in the electrocautery group, which was significantly lower than 1.9 (0.82) mmol/L in the no-electrocautery group (p = 0.002). The incidence of hypoglycemia was significantly lower in the electrocautery group than in the no-electrocautery group (2.2% vs. 5.7%, p = 0.035). Conclusions: Monopolar electrocautery during cesarean section affects the fetus, but it is safe to use it. Electrocautery is independently associated with umbilical cord blood pH and calcium level. Electrocautery may be associated with a lower incidence of hypoglycemia.
Breathing for Two: Asthma Management, Treatment, and Safety of Pharmacological Therapy during Pregnancy
Authors: Javorac Jovan , Živanović Dejan , Zvezdin Biljana , Mijatović Jovin Vesna
Published: September 2024

The primary objectives of asthma management during pregnancy are to achieve adequate symptom control, reduce the risk of acute exacerbations, and maintain normal pulmonary function, all of which contribute to ensuring the health and well-being of both the mother and the baby. The Global Initiative for Asthma (GINA) recommends that pregnant women with asthma continue using asthma medications throughout pregnancy, as the benefits of well-controlled asthma for both the mother and fetus outweigh the potential risks of medication side effects, poorly controlled asthma, and exacerbations. The classification of asthma medications by the US Food and Drug Administration (FDA) into categories A, B, C, D, and X is no longer applied. Instead, the potential benefits and risks of each medication during pregnancy and lactation are considered individually. The use of medications to achieve good asthma control and prevent exacerbations during pregnancy is justified, encompassing inhaled corticosteroids (ICS), some leukotriene receptor antagonists (LTRA), short-acting beta-2 agonists (SABA), long-acting beta-2 agonists (LABA), short-acting muscarinic antagonists (SAMA), long-acting muscarinic antagonists (LAMA), and, recently, biological therapies, even in the absence of definitive safety data during pregnancy.
Comparative Analysis of Microbial Communities in Diseased and Healthy Sweet Cherry Trees (Prunus avium L.)
Authors: Zhou Tong , Huang Xiaojuan , Zhu Danyang , Tang Yan , Xu Hongli , Ran Fanrong , Ullah Hasin , Tan Jiangli
Published: September 2024

The European sweet cherry Prunus avium (L.), a member of the Rosaceae family, is one of the most popular and economically valuable fruits. However, the rapid spread of gummosis and poor management practices have become the major obstacles to their production. To identify pathogenic microorganisms responsible for gummosis disease, we conducted observations comparing the garden of Bailuyuan, which heavily suffered from gummosis disease and horn beetle damage, with the orchard of Mayuhe, which only suffered from gummosis disease, both from Xi’an, Shaanxi, China. Samples were obtained from the healthy tissues and gummosis disease tissues that used the Illumina sequence of 16S rRNA and the internal transcribed spacer region (ITS) to identify bacterial and fungal communities in these samples. An alpha diversity analysis revealed a significantly higher fungal diversity of disease than in healthy tissue in the gummosis period. The results suggested that an imbalance in the fungal genera may be associated with gummosis disease. Species relative analyses showed some bacterial genera (Pelagibacterium, Halomonas, Azospirillum, Aquabacterium and Alistipes) and fungal genera (Penicillium, Alternaria and Rhodotorula) in the diseased tissues of gummosis. Among these, the increased relative abundance of the bacteria genes Halomonas, Pelagibacterium, Chelativorans, Pantoea, Aquabacterium, Alternaria and fungi genes Penicillium, Cystobasidium, Rhodotorula may be associated with gummosis of P. avium. The bacterial genera Methylobacterium, Psychroglaciecola, Aeromonas, Conexibacter and fungal genera Didymella, Aureobasidium, Mycosphaerella, Meyerozyma are probably antagonists of the pathogen of gummosis. These findings are an initial step in the identification of potential candidates for the biological control of the disease.
Effect of Ionic Liquids with Different Structures on Rheological Properties of Water-Based Drilling Fluids and Mechanism Research at Ultra-High Temperatures
Authors: Shi Haoxian , Yu Yanjiang , Wang Yingsheng , Ning Zijie , Luo Zhihua
Published: September 2024

The rheology control of water-based drilling fluids at ultra-high temperatures has been one of the major challenges in deep or ultra-deep resource exploration. In this paper, the effects of 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonimide) (ILA), 1-ethyl-3-methylimidazolium tetrafluoroborate (ILB) and N-methyl, butylpyrrolidinium bis(trifluoromethanesulfonimide) (ILC) on the rheological properties and filtration loss of polymer-based slurries at ultra-high temperatures (200 °C and 240 °C) are investigated by the American Petroleum Institute (API) standards. The results show that ionic liquids with different structures could improve the high-temperature rheological properties of polymer-based drilling fluids. The rheological parameter value (YP/PV) of the polymer-based slurry formulated with ILC is slightly higher than that with ILA at the same concentration, while the YP/PV value of the polymer-based slurry with ILA is slightly higher than that with ILB, which is consistent with the TGA thermal stability of ILA, ILB, and ILC; the thermal stability of ILC with pyrrolidine cations is higher than that of ILA with imidazole cations, and the thermal stability of ILA with bis(trifluorosulfonyl)amide anions is higher than that of ILB with tetrafluoroborate anions. Cation interlayer exchange between organic cation and sodium montmorillonite can improve the rheological properties of water-based drilling fluids. And meantime, the S=O bond in bis(trifluorosulfonyl)amide ions and the hydroxyl group of sodium montmorillonite may form hydrogen bonds, which also may increase the rheological properties of water-based drilling fluids. ILA, ILB, and ILC cannot reduce the filtration loss of polymer-based drilling fluids at ultra-high temperatures.
Carbon Dots: A Versatile Platform for Cu2+ Detection, Anti-Counterfeiting, and Bioimaging
Authors: Wang Qian , He Xinyi , Mao Jian , Wang Junxia , Wang Liangliang , Zhang Zhongchi , Li Yongfei , Huang Fenglin , Zhao Bin , Chen Gang , He Hua
Published: September 2024

Carbon dots (CDs) have garnered extensive interest in basic physical chemistry as well as in biomedical applications due to their low cost, good biocompatibility, and great aqueous solubility. However, the synthesis of multi-functional carbon dots has always been a challenge for researchers. Here, we synthesized novel CDs with a high quantum yield of 28.2% through the straightforward hydrothermal method using Diaminomaleonitrile and Boc-D-2, 3-diaminopropionic acid. The size, chemical functional group, and photophysical properties of the CDs were characterized by TEM, FTIR, XPS, UV, and fluorescence. It was demonstrated in this study that the prepared CDs have a high quantum yield, excellent photostability, and low cytotoxicity. Regarding the highly water-soluble property of CDs, they were proven to possess selective and sensitive behavior against Cu2+ ions (linear range = 0–9 μM and limit of detection = 1.34 μM). Moreover, the CDs were utilized in fluorescent ink in anti-counterfeiting measures. Because of their low cytotoxicity and good biocompatibility, the CDs were also successfully utilized in cell imaging. Therefore, the as-prepared CDs have great potential in fluorescence sensing, anti-counterfeiting, and bioimaging.
TSPO Radioligands for Neuroinflammation: An Overview
Authors: Salerno Silvia , Viviano Monica , Baglini Emma , Poggetti Valeria , Giorgini Doralice , Castagnoli Jacopo , Barresi Elisabetta , Castellano Sabrina , Da Settimo Federico , Taliani Sabrina
Published: September 2024

The translocator protein (TSPO) is predominately localized on the outer mitochondrial membrane in steroidogenic cells. In the brain, TSPO expression, low under normal conditions, results upregulated in response to glial cell activation, that occurs in neuroinflammation. As a consequence, TSPO has been extensively studied as a biomarker of such conditions by means of TSPO-targeted radiotracers. Although [11C]-PK11195, the prototypical TSPO radioligand, is still widely used for in vivo studies, it is endowed with severe limitations, mainly low sensitivity and poor amenability to quantification. Consequently, several efforts have been focused on the design of new radiotracers for the in vivo imaging of TSPO. The present review will provide an outlook on the latest advances in TSPO radioligands for neuroinflammation imaging. The final goal is to pave the way for (radio)chemists in the future design and development of novel effective and sensitive radiopharmaceuticals targeting TSPO.
The Clinical Manifestations, Risk Factors, Etiologies, and Outcomes of Adult Patients with Infectious Meningitis and Encephalitis: Single Center Experience
Authors: Makkawi Seraj , Alqurashi Shatha , Hubayni Wejdan , Almahdawi Saleha , Bahkali Sadeem , Alharbi Abeer , Khojah Osama , Halawani Aisha , Malli Israa
Published: September 2024

(1) Background: Central nervous system (CNS) infections, including meningitis and encephalitis, are serious conditions which are associated with high morbidity and mortality. This study aims to identify the clinical manifestations, etiologies, and outcomes of meningitis and encephalitis in adult patients in Saudi Arabia, addressing the current gap in understanding these conditions within this population. (2) Methods: This is a single-center retrospective study which included all adult patients diagnosed with meningitis and encephalitis from March 2016 to May 2022. (3) Results: This study found that most cases of meningitis and encephalitis occurred due to unknown pathogens. Pretreatment with antibiotics prior to lumbar puncture (LP) was found in 71.2% of patients with meningitis. Altered mental status and seizures were common presenting symptoms among patients with encephalitis while altered mental status and fever were common among patients with meningitis. (4) Conclusions: Adherence to guidelines in treating meningitis and encephalitis and performing LPs in a timely manner are important. Establishing national biobanks with biological samples from patients suspected of having meningitis or encephalitis will significantly enhance our understanding of these conditions in Saudi Arabia.
Fluorescein Angiography for Monitoring Neural Blood Flow in Chronic Nerve Compression Neuropathy: Experimental Animal Models and Preliminary Clinical Observations
Authors: Saito Kosuke , Okada Mitsuhiro , Yokoi Takuya , Hama Shunpei , Nakamura Hiroaki
Published: September 2024

Pathologies associated with neural blood disturbance have been reported in patients with chronic nerve compression (CNC) neuropathy. Fluorescein angiography (FAG) and laser Doppler flowmetry (LDF) are effective for real-time peripheral nerve blood flow assessment. However, their reliability in severe neuropathy models in large animals or clinical conditions remains unclear. Initially, we aim to apply FAG to two different CNC animal models and evaluate their characteristics in comparison with those of LDF. In FAG, we quantified the peak luminance at the compression site following fluorescein injection. Then, we positioned the LDF probe at the center of the compression site and recorded the blood flow. Subsequently, we analyzed whether the FAG characteristics obtained in this animal experiment were consistent with those of clinical studies in patients with severe carpal tunnel syndrome (CTS). In the CNC rat model, FAG and LDF effectively monitored reduced neural blood flow over time. We observed significant blood flow reduction using both techniques in a newly developed severe CNC rabbit model. Notably, FAG correlated strongly with the compound muscle action potential (CMAP) amplitude in electrodiagnostic findings, unlike LDF. As a next step, we performed FAG after open carpal tunnel release in clinical cases of CTS. FAG correlated significantly with preoperative CMAP amplitude. This indicates FAG’s importance for assessing nerve blood flow during surgery, potentially improving diagnostic accuracy and surgical outcomes.
Comparison of the Nutritional Adequacy of Current Food-Based Very Low Energy Diets: A Review and Nutritional Analysis
Authors: Poon Shirley Wing Yan , Brown Robyn Mary , Sumithran Priya
Published: September 2024

Very low energy diets (VLEDs) contain <800 kcal/day and typically comprise formulated meal replacement products with adequate protein and micronutrients. Food-based VLEDs are an alternative approach, but it is uncertain whether they can provide adequate nutrition within an 800 kcal/day restriction. This analysis aimed to assess the nutritional adequacy of food-based VLEDs compared with formula VLEDs. A systematized literature review was conducted to identify balanced food-based VLEDs by searching five scientific databases from inception to 23 March 2023 and online sources between 1 and 7 May 2023. Ultimately, nine diets were analyzed for nutritional content and compared with Codex Alimentarius standards for formula foods, and Australian estimated average requirement and adequate intake (AI) for adults 19–50 years. Optifast® was used as a comparator. None of the VLEDs met all nutritional benchmarks. Three food-based diets had nutrient profiles similar to formula VLEDs, with one being adequate for all nutrients except thiamine, magnesium and zinc in men and iron in women. All VLEDs, including Optifast®, did not meet AI for dietary fiber, except one. In general, food-based VLEDs offered more fiber than Optifast®. In conclusion, food-based VLEDs were inadequate in certain micronutrients but offered more dietary fiber than formula VLEDs. These nutritional deficits do not preclude food-based VLEDs from being recommended, provided they are addressed.
Joint Trajectories of Lifestyle Indicators and Their Associations with Blood Pressure among Chinese Middle School Students
Authors: Jing Guangzhuang , Liu Xinxin , Shi Jiaojiao , Xue Junlei , Peng Hui , Shi Huijing
Published: September 2024

Lifestyle behaviors, defined as a combination of dietary behavior, physical activity (PA), screen time (ST), and sleep duration indicators, are strongly associated with blood pressure (BP) in students. Our aim was to characterize the joint trajectories of lifestyle behaviors among middle school students and evaluate their association with BP. Data were obtained from the monitoring dataset on common diseases and health factors among students in Jiading District, Shanghai, China, conducted from 2019 to 2023. Lifestyle behavior data were collected annually from middle school students aged 12–18 years through questionnaires covering dietary behavior score, PA, ST, and sleep duration. Students’ BP was measured in 2023. Joint trajectories of lifestyle behaviors were determined using group-based multi-trajectory modeling. Associations between lifestyle trajectories and students’ BP were examined using multiple linear regression and modified Poisson regression. A total of 1378 middle school students (759 [58.98%] boys, median age 14.36 years [IQR: 13·30–13.28]) with lifestyle behaviors data assessed at least three times were included, and they were categorized into four joint lifestyle trajectories as follows: “remain unhealthy with low PA and increasing ST” (n = 141, 10.46%), “remain unhealthy with only low PA” (n = 305, 22.63%), “change towards unhealthy with decreasing sleep duration” (n = 776, 57.57%), and “relatively healthy” (n = 126, 9.35%). After adjusting for important confounders, the “remain unhealthy with low PA and increasing ST” group was associated with higher diastolic BP (DBP) [β: 3.49, 95% CI: 0.55–6.44] and higher mean arterial pressure (MAP) [β: 3.19, 95% CI: 0.37–6.01] in students compared with the “relatively healthy” group. Additionally, compared with the “relatively healthy” group, students in the “remain unhealthy with low PA and increasing ST” group had a 1.12-fold increase in the risk of hypertension (risk ratios: 1.12, 95% CI: 1.03–1.24). All trend p values in DBP, MAP, and hypertension from the “relatively healthy” group to the “remain unhealthy with low PA and increasing ST” group were less than 0.05. Four distinct lifestyle trajectories were identified among middle school students. Students who remained in the “unhealthy with low PA and increasing ST” lifestyle trajectory were associated with later elevations in BP.
Potential Application of Plant-Derived Compounds in Multiple Sclerosis Management
Authors: Woodfin Seth , Hall Sierra , Ramerth Alexis , Chapple Brooke , Fausnacht Dane , Moore William , Alkhalidy Hana , Liu Dongmin
Published: September 2024

Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurodegeneration, resulting in significant disability and reduced quality of life. Current therapeutic strategies primarily target immune dysregulation, but limitations in efficacy and tolerability highlight the need for alternative treatments. Plant-derived compounds, including alkaloids, phenylpropanoids, and terpenoids, have demonstrated anti-inflammatory effects in both preclinical and clinical studies. By modulating immune responses and promoting neuroregeneration, these compounds offer potential as novel adjunctive therapies for MS. This review provides insights into the molecular and cellular basis of MS pathogenesis, emphasizing the role of inflammation in disease progression. It critically evaluates emerging evidence supporting the use of plant-derived compounds to attenuate inflammation and MS symptomology. In addition, we provide a comprehensive source of information detailing the known mechanisms of action and assessing the clinical potential of plant-derived compounds in the context of MS pathogenesis, with a focus on their anti-inflammatory and neuroprotective properties.
Responsiveness and Reliability of a Sipping Device to Measure Motivation in Normal-Weight Individuals and Bariatric Surgery Patients
Authors: Hamm Jeon D. , Laferrère Blandine , Albu Jeanine B. , Kini Subhash , Pi-Sunyer Xavier , Kissileff Harry R.
Published: September 2024

There is an urgent need to measure the motivation to taste a sweet fluid in order to determine the influence of sweet tastes on the potential choices and consumption of beverages in patients with obesity. Current methods utilize either survey instruments or arbitrary operant tasks. The sipometer enables the participant to utilize an actual ingestive behavioral response to measure motivation during access to beverages on either ad libitum (AL) or progressive time ratio (PR) schedules. We determined the sipometer’s responsiveness and reliability as a test of change in motivation for sweet tastes after bariatric surgery. Participants (58 patients and 28 controls, BMI: 18.5–24.9 kg/m2) sham-consumed an aspartame-sweetened (S) and non-sweetened (N) beverage under AL and PR schedules at a pre-surgery/baseline and a 3-month and 24-month visit (patients only). Cumulative pressure (CumPres), a measure of effort, was the sum of the pressures exerted during sipping under each condition. Baseline CumPres for PRS was higher than ALS and ALN in patients (p < 0.03) and higher than PRN in controls (p = 0.009). At 3 months, CumPres did not differ amongst conditions in patients, but CumPres for PRS was higher than all other conditions in controls (p < 0.0005). There were no baseline group differences; however, patients’ CumPres for PRS was lower than controls’ at 3 months (p = 0.002). Patients’ CumPres for PRS decreased non-significantly between the baseline and 3 months but increased at 24 months compared to 3 months (p = 0.025) and was no different from baseline. Controls’ CumPres for PRS increased at 3 months (p = 0.0359), but CumPres for all conditions was correlated between visits (p’s < 0.038). The sipometer is a reliable and sensitive measure of motivation to consume sweet beverages and may reflect changes in post-operative energy intake.
Analysis of Gut Bacterial and Fungal Microbiota in Children with Autism Spectrum Disorder and Their Non-Autistic Siblings
Authors: Retuerto Mauricio , Al-Shakhshir Hilmi , Herrada Janet , McCormick Thomas S. , Ghannoum Mahmoud A.
Published: September 2024

Autism Spectrum Disorder (ASD) is a multifactorial disorder involving genetic and environmental factors leading to pathophysiologic symptoms and comorbidities including neurodevelopmental disorders, anxiety, immune dysregulation, and gastrointestinal (GI) abnormalities. Abnormal intestinal permeability has been reported among ASD patients and it is well established that disturbances in eating patterns may cause gut microbiome imbalance (i.e., dysbiosis). Therefore, studies focusing on the potential relationship between gut microbiota and ASD are emerging. We compared the intestinal bacteriome and mycobiome of a cohort of ASD subjects with their non-ASD siblings. Differences between ASD and non-ASD subjects include a significant decrease at the phylum level in Cyanobacteria (0.015% vs. 0.074%, p < 0.0003), and a significant decrease at the genus level in Bacteroides (28.3% vs. 36.8%, p < 0.03). Species-level analysis showed a significant decrease in Faecalibacterium prausnitzii, Prevotella copri, Bacteroides fragilis, and Akkermansia municiphila. Mycobiome analysis showed an increase in the fungal Ascomycota phylum (98.3% vs. 94%, p < 0.047) and an increase in Candida albicans (27.1% vs. 13.2%, p < 0.055). Multivariate analysis showed that organisms from the genus Delftia were predictive of an increased odds ratio of ASD, whereas decreases at the phylum level in Cyanobacteria and at the genus level in Azospirillum were associated with an increased odds ratio of ASD. We screened 24 probiotic organisms to identify strains that could alter the growth patterns of organisms identified as elevated within ASD subject samples. In a preliminary in vivo preclinical test, we challenged wild-type Balb/c mice with Delftia acidovorans (increased in ASD subjects) by oral gavage and compared changes in behavioral patterns to sham-treated controls. An in vitro biofilm assay was used to determine the ability of potentially beneficial microorganisms to alter the biofilm-forming patterns of Delftia acidovorans, as well as their ability to break down fiber. Downregulation of cyanobacteria (generally beneficial for inflammation and wound healing) combined with an increase in biofilm-forming species such as D. acidovorans suggests that ASD-related GI symptoms may result from decreases in beneficial organisms with a concomitant increase in potential pathogens, and that beneficial probiotics can be identified that counteract these changes.
Gabapentin-Induced Adrenal Insufficiency: The Hypothalamic-Pituitary-Adrenal Axis Stress Misresponse and Risk of Infection: A Case Report and Literature Review
Authors: Pechlivanidou Evmorfia , Chatzikyriakos Alexandros , Zisi Maria Anna , Paraskevopoulos Nikolaos , Kaltsa Semeli , Konstantas Orestis K. , Zogakis Panteleimon , Catsouli Aikaterini , Sekouris Nick , Margariti Rodanthi E.
Published: September 2024

This literature review, in light of the presented case report, explores the complex interplay between gabapentin (GBP), a gamma-aminobutyric acid (GABA) analog, and the hypothalamic–pituitary–adrenal (HPA) axis in patients undergoing major surgical procedures. It specifically investigates the potential impact of GBP on cortisol levels, stress responses, and infection risk, illustrated by a detailed clinical case. This review combines a comprehensive literature search with a case report of a 17-year-old male with osteosarcoma who experienced transient adrenal insufficiency and infections while receiving GBP. The case is analyzed in the context of the existing literature on GBP and the HPA axis. The findings highlight the intricate relationship between GBP use, adrenal insufficiency, and infection susceptibility. It underscores the need for further research and clinical vigilance when prescribing GBP to patients with underlying medical conditions, particularly in the context of major surgical procedures. The review underscores the need for further research and clinical vigilance when prescribing GBP, particularly in perioperative settings. In conclusion, GBP’s effects on the HPA axis and immune responses are complex and multifaceted. Clinicians should exercise caution when prescribing GBP, especially for patients with underlying conditions undergoing major surgery. Further research is needed to elucidate the mechanisms of GBP’s influence on cortisol levels and stress responses.
Ferulic Acid Alleviates Radiation-Induced Immune Damage by Acting on JAK/STAT Signaling Pathway
Authors: Huang Mingyue , Ye Anping , Zhang Haoyu , Chen Junru , Yang Tingyu , Wei Xue , Gao Yue , Ma Zengchun
Published: September 2024

The disruption of hematopoietic and immune functions is a significant consequence of the long-term effects of radiation exposure. This study investigated the potential mechanisms by which ferulic acid (FA) acts as a radioprotective agent in mitigating radiation-induced immune damage. C57BL/6J mice were exposed to a dose of 6.0 Gy of 60Co γ irradiation. FA was administered at doses of 25, 50, and 100 mg/kg/d for 7 days before and 30 days following irradiation. We evaluated changes in peripheral blood cells, T and B lymphocytes, natural killer cells in the spleen, and hematopoietic stem/progenitor cells in the bone marrow (BM). Whole-genome transcriptome sequencing of BM was performed to explore potential mechanisms. FA administration resulted in a significant reduction in malonaldehyde levels (p < 0.0001), an increase in catalase and beta-nicotinamide adenine dinucleotide levels in serum (p < 0.05), and enhanced multipotent progenitors (p < 0.01) and common lymphoid progenitors (p < 0.05) in the BM. Additionally, there was an elevation in white blood cell levels, red blood cell levels, and hemoglobin levels in peripheral blood (p < 0.01). Transcriptome analysis indicated that FA reversed the radiation-induced expression of genes related to immunity and inflammation. Enzyme-linked immunosorbent assay experiments further demonstrated that FA reduced interleukin-6 levels in the BM and decreased JAK1, JAK2, and STAT3 protein content (p < 0.01). In conclusion, FA might mitigate hematopoietic and immune damage by modulating the JAK/STAT signaling pathway.
A Grant Report: Examining the Efficacy of Remote Photobiomodulation Therapy in Adolescents with Major Depressive Disorder
Authors: Alberti Adriano , Vieira Willians Fernando , Coelho David Richer Araujo , Fernandes Martins Daniel
Published: September 2024

Major depressive disorder (MDD) is a prevalent mental health condition affecting a significant portion of the population worldwide. This condition can impact individuals of all ages, including adolescents, leading to an impact on various aspects of their lives. Adolescence is a crucial phase of human development, characterized by several neurobiological changes. The onset of MDD during this period can result in damage not only to teenagers but also might have long-lasting implications for their future as adults. Notably, the onset of MDD in adolescents is often associated with various biomarkers, such as increased levels of inflammatory cytokines (e.g., IL-6, TNF-α), oxidative stress markers, and alterations in neurotransmitter levels, indicating a complex interplay of biological factors. Therefore, early intervention is essential for addressing MDD during this phase. Photobiomodulation therapy (PBMT) emerges as an innovative and promising approach that utilizes light, especially in the near-infrared (NIR) and red spectra, to trigger biological and therapeutic effects. Notably, targeting the skull and abdomen with PBMT might explore the bidirectional communication between the intestinal system and the central nervous system in a remote and/or systemic way. In this context, we present the rationale and design of an ongoing study aiming to assess the efficacy of PBMT on depressive symptoms and biomarkers associated with oxidative stress and mitochondrial function in adolescents with MDD.
Tunable Characteristics of Wedge Plasmonic Waveguide with Thin Metallic Layers
Authors: Thi Ha Trinh , Van Duong Nguyen , Van Hieu Dang , Chu Hoang Manh
Published: September 2024

In this study, we propose a mechanism for tuning the modal characteristics of a wedge plasmonic waveguide. The wedge plasmonic waveguide is composed of a thin metallic layer deposited on a wedge-shaped dielectric waveguide. The tuning mechanism is based on controlling the surface plasmon polariton (SPP) mode at the interface between the metal layer and the dielectric waveguide instead of controlling the SPP mode at the interface between the wedge-shaped metal layer and the surrounding media. This mechanism is performed by modulating the effective refractive index of the dielectric waveguide using a closely coupled tuning waveguide. The numerically investigated results show that the propagation length of the device can be tuned more than 100%; this characteristic has not been explored yet in previous studies. The effective mode area with deep-subwavelength size is almost kept constant while tuning the propagation length. This study offers new insights into tailoring the modal characteristics of plasmonic waveguides based on controlling the mode property at the interface between the metal layer and the dielectric waveguide. This study is also a guideline for developing active plasmonic devices such as tunable nanoscale lightwave guiding waveguides and THz optic modulators.
Reservoir Porosity Construction Based on BiTCN-BiLSTM-AM Optimized by Improved Sparrow Search Algorithm
Authors: Qiao Lei , Gao Haijun , Cui You , Yang Yang , Liang Shixin , Xiao Kun
Published: September 2024

To evaluate reservoir porosity accurately, a method based on the bidirectional temporal convolutional network (BiTCN), bidirectional long short-term memory network (BiLSTM), and attention mechanism (AM) optimized by the improved sparrow search algorithm (ISSA) is proposed. Firstly, the sparrow search algorithm improved by a phased control step size strategy and dynamic random Cauchy mutation is introduced. Secondly, the superiority of the ISSA is confirmed by the test functions of Congress on Evolutionary Computation in 2022 (CEC-2022). Furthermore, the experimental findings are assessed using the Wilcoxon test, which provides additional evidence of the ISSA’s superiority against the competing algorithms. Finally, the BiTCN-BiLSTM-AM is optimized by the ISSA, and the ISSA-BiTCN-BiLSTM-AM was applied to reservoir porosity construction in the Midlands basin. The results showed that the RMSE and MAE of the proposed model were 0.4293 and 0.5696, respectively, which verified the effectiveness and success rate of reservoir parameter construction by addressing the shortcomings in the capabilities shown by conventional interpretation procedures.
Stock and Customized Abutments Supporting Implant Restorations: Current Aspects and Future Perspectives of Biological and Mechanical Complications
Authors: Di Francesco Fabrizio , Minervini Giuseppe , Lanza Alessandro
Published: September 2024

Dental implantology has advanced significantly in the last few decades, transforming restorative dentistry and providing patients with better oral health, appearance, and quality of life [...]
“Sharing Worldviews: Learning in Encounter for Common Values in Diversity” in School and Teacher Education—Contexts in Germany and Europe
Authors: Boehme Katja
Published: September 2024

Challenges and tensions that arise in a pluralistic society with differing worldviews among its citizens must be addressed from the outset in school education. To enable social cohesion within a heterogeneous society, students must learn to harmonize their own worldviews with other interpretations of the world in a spirit of “reciprocal inclusivity” (Reinhold Bernhardt). This article argues that this task particularly falls within the responsibility of subjects in schools that address the existential “problems of constitutive rationality” (Jürgen Baumert), specifically religious education, ethics, and philosophy. In Germany and Austria, multiple subjects within denominational religious education, as well as ethics and philosophy, are offered in schools. When these subjects collaborate on projects, students learn to engage in dialogue with the various religious and secular, individual, and collective interpretations, perspectives, and worldviews they encounter. Since 2002/03, and in teacher training since 2011, such a didactically guided Sharing Worldviews approach has been implemented in school projects in Southern Germany through a four-phase concept. This concept can be flexibly applied to the local conditions of the school, contributes to internationalisation and digitalisation, and does not require additional teaching hours. By incorporating secular worldviews, Sharing Worldviews goes beyond interreligious learning and has also been realised digitally in other European countries. The following article begins by considering the educational requirements in a heterogeneous society (1), describes the prerequisites needed to positively influence students’ attitudes (2), outlines common foundational concepts for interreligious and inter-worldview dialogue (3), and recommends “Mutual Hospitality” as the basis for such dialogue in schools (4). The article then explains how “Mutual Hospitality” can be practically implemented in a four-phase concept of Sharing Worldviews both in schools and in teacher training (5 and 6) by tracing the origins of this concept (7). The Sharing Worldviews concept has been both internationalised and digitalised in schools and teacher education (8), aligns with the educational principles of the OECD (9), and demonstrates significant benefits in empirical studies (10).
Students in Higher Education Explore the Practice of Gratitude as Spirituality and Its Impact on Well-Being
Authors: Fuertes Al
Published: September 2024

Gratitude, defined by many as being thankful and appreciative of things that make life and relationships meaningful and purposeful, catalyzes holistic well-being. It is considered a manifestation of both inner and outer spirituality and develops spiritual growth. In this article, twenty-three students from a large public university in the U.S. representing various faith traditions explore the practice of gratitude as spirituality and its impact on well-being. The purpose of this article is to demonstrate how gratitude, also conceptualized and articulated by college students as spirituality, influences students’ well-being. By exploring common and unique themes based on students’ individual reflections and synthesis on their weekly journal entries on the topic of gratitude as spirituality toward well-being, students assert that first, practicing gratitude enables them to experience something of the essence of spirituality, which is about interconnectedness and bringing into focus the things in life that they must be contented with and happy about. Second, expressing gratitude helps shift students’ perspectives by looking at conflict more as an opportunity for growth and constructive change than anything else. It redirects their mindset to transforming conflict’s negative and destructive energies into something beneficial, although the process might seem difficult. Third, practicing gratitude improves students’ overall mental, physical, spiritual, and social well-being. It helps them develop a sense of empathy and understanding toward others and aids them with better communication, deeper connections, and awareness of the self and their surroundings. This article concludes that there is, indeed, a dynamic interplay between gratitude and spirituality regarding students’ well-being. The article recommends that academic institutions and teachers of higher education provide students with classroom and public spaces to integrate conversations around gratitude, spirituality, and well-being into their academic studies as this helps enrich students’ overall learning experiences.
Changes in the Role and Status of Women in the Nigerian Baptist Convention, 1914–2021
Authors: Ojo Matthews A. , Ajani Ezekiel Oladapo
Published: September 2024

This study interrogates the changes in the roles and status of women in the Nigerian Baptist Convention, the largest Baptist denomination in Africa, with over 10,104 churches and about 11 million members. This paper attempts to answer the critical question of how and what processes stimulated and sustained the changes in the role and status of women among Nigerian Baptists from the colonial period to the contemporary era. This paper relied on primary source publications, interviews, and secondary publications, which provided invaluable data in analysing the historical and contemporary issues that have resulted in the changing roles and status of women in the Nigerian Baptist Convention. This study found that against patriarchal traditions that subordinated women to domestic activities in the homes, such factors as access to formal education, the formation of Women’s Missionary Union as an institutional framework to mainstream women’s religious activities, the employment of women with doctoral degrees as theological educators in Baptist seminaries in the 1980s, the ordination of women as Baptist ministers in the late 1990s, and the appointment of women to key positions in the Nigerian Baptist Convention were major factors that moved women from traditional subordinate positions to public leadership in the church. Generally, this has indirectly stirred a process of empowerment for women and agitation for equality with men in the NBC in the past one hundred years. This study concluded that this development has moved women from supportive roles to taking up significant leadership positions within an African patriarchal cultural system.
Validation and Comparison of Long-Term Accuracy and Stability of Global Reanalysis and Satellite Retrieval AOD
Authors: Su Xin , Huang Ge , Wang Lin , Wei Yifeng , Ma Xiaoyu , Wang Lunche , Feng Lan
Published: September 2024

Reanalysis and satellite retrieval are two primary approaches for obtaining large-scale and long-term Aerosol Optical Depth (AOD) datasets. This study evaluates and compares the accuracy, long-term stability, and error characteristics of the MERRA-2, MODIS combined Dark Target and Deep Blue (DT&DB), and VIIRS DB AOD products globally and regionally. The results indicate that the MERRA-2 AOD exhibits the highest accuracy with an expected error (EE, ±0.05 ± 20%) of 83.24% and mean absolute error (MAE) of 0.056, maintaining a stability of 0.010 per decade. However, since the MERRA-2 AOD ceased assimilating observations other than the MODIS AOD in 2014, its accuracy decreased by approximately 5.6% in the EE metric after 2014. The VIIRS Deep Blue (DB) AOD product, with an EE of 79.43% and stability of 0.016 per decade, is slightly less accurate and stable compared to the MERRA-2 AOD. The MODIS DT&DB AOD demonstrates an EE of 76.75% and stability of 0.011 per decade. Regionally, the MERRA-2 AOD performs acceptably in most areas, especially in low-aerosol-loading regions, with an EE > 86% and stability ~0.02 per decade. The VIIRS DB AOD excels in high-aerosol-loading regions, such as the Indian subcontinent, with an EE of 69.14% and a stability of 0.049 per decade. The performance of the MODIS DT&DB AOD falls between that of VIIRS DB and MERRA-2 across most regions. Overall, each product meets the accuracy and stability metrics globally, but users need to select the appropriate product for analysis based on the validation results of the accuracy and stability in different regions.
GMS-YOLO: An Algorithm for Multi-Scale Object Detection in Complex Environments in Confined Compartments
Authors: Ding Qixiang , Li Weichao , Xu Chengcheng , Zhang Mingyuan , Sheng Changchong , He Min , Shan Nanliang
Published: September 2024

Many compartments are prone to pose safety hazards such as loose fasteners or object intrusion due to their confined space, making manual inspection challenging. To address the challenges of complex inspection environments, diverse target categories, and variable scales in confined compartments, this paper proposes a novel GMS-YOLO network, based on the improved YOLOv8 framework. In addition to the lightweight design, this network accurately detects targets by leveraging more precise high-level and low-level feature representations obtained from GhostHGNetv2, which enhances feature-extraction capabilities. To handle the issue of complex environments, the backbone employs GhostHGNetv2 to capture more accurate high-level and low-level feature representations, facilitating better distinction between background and targets. In addition, this network significantly reduces both network parameter size and computational complexity. To address the issue of varying target scales, the first layer of the feature fusion module introduces Multi-Scale Convolutional Attention (MSCA) to capture multi-scale contextual information and guide the feature fusion process. A new lightweight detection head, Shared Convolutional Detection Head (SCDH), is designed to enable the model to achieve higher accuracy while being lighter. To evaluate the performance of this algorithm, a dataset for object detection in this scenario was constructed. The experiment results indicate that compared to the original model, the parameter number of the improved model decreased by 37.8%, the GFLOPs decreased by 27.7%, and the average accuracy increased from 82.7% to 85.0%. This validates the accuracy and applicability of the proposed GMS-YOLO network.
Understanding How Image Quality Affects Transformer Neural Networks
Authors: Varga Domonkos
Published: September 2024

Deep learning models, particularly transformer architectures, have revolutionized various computer vision tasks, including image classification. However, their performance under different types and levels of noise remains a crucial area of investigation. In this study, we explore the noise sensitivity of prominent transformer models trained on the ImageNet dataset. We systematically evaluate 22 transformer variants, ranging from state-of-the-art large-scale models to compact versions tailored for mobile applications, under five common types of image distortions. Our findings reveal diverse sensitivities across different transformer architectures, with notable variations in performance observed under additive Gaussian noise, multiplicative Gaussian noise, Gaussian blur, salt-and-pepper noise, and JPEG compression. Interestingly, we observe a consistent robustness of transformer models to JPEG compression, with top-5 accuracies exhibiting higher resilience to noise compared to top-1 accuracies. Furthermore, our analysis highlights the vulnerability of mobile-oriented transformer variants to various noise types, underscoring the importance of noise robustness considerations in model design and deployment for real-world applications. These insights contribute to a deeper understanding of transformer model behavior under noisy conditions and have implications for improving the robustness and reliability of deep learning systems in practical scenarios.
Behind the Kitchen Doors: Unveiling Post-COVID Challenges and Sustainable Solutions for Chefs in the Hospitality Sector
Authors: Ozbasar Kurtulus , Saydam Mehmet Bahri , Ozturen Ali , Ardahan Mehmet Guven
Published: September 2024

This study aims to provide a comprehensive exploration of the multifaceted barriers experienced by chefs working within the dynamic and demanding landscape of the hospitality industry. By delving into the intricacies of their work environment, we aim to shed light on the day-to-day hurdles they encounter, offering a detailed understanding of the obstacles they face. In our study, we employed a qualitative research framework to investigate the challenges faced by chefs in the hospitality sector, focusing on their unique experiences. Our data collection involved in-depth interviews with chefs in North Cyprus. Our findings reveal seven predominant problems within the culinary industry, encompassing workload and stress, customer expectations, menu creativity and innovation, team dynamics, career advancements, ingredient sourcing, and technology and automation. These insights serve as a valuable resource for industry professionals and researchers alike who are committed to enhancing the culinary profession and elevating the dining experience for customers. The originality of this study lies in its unique focus on addressing the underrepresented area of research concerning the specific barriers faced by chefs in the tourism and hospitality industry. By exploring the day-to-day hurdles encountered by chefs, this research contributes to both academic knowledge and practical insights that can enhance industry practices and ultimately improve the quality of dining experiences for guests.