bluuebunny/crossref_metadata_2025 huggingface dataset:
Anxiety-depressive disorders in patients with bronchial asthma combined with erosive-ulcerative lesions of gastro-duodenal area
Authors: Beloborodova E. I. , Chernyavskaya G. M. , Oustyuzhanina Ye. A. , Maksimenko G. V. , Kalatcheva T. P.
Published: April 2021

The aim of the study was to investigate peculiarities of anxiety-depressive disorders (ADD) course in patients with bronchial asthma (BA) combined with erosive-ulcerative lesions (EUL) of gastro-duodenal area (GDA) and their interaction and to evaluate the treatment efficacy in this category of patients taking into consideration their psycho-pathological disorders. Combination of BA and EUL of GDA was established to enhance psychological tension degree and increase ADD which requires pharmacological cor-rection.
Peculiarities of functional neutrophil activity in rats having periodontitis in thesetting of toxic hepatitis
Authors: Vokhmintseva L. V. , Mayanskaya N. N. , Rymar′ S. S. , Zheleznyi P. A. , Nadeyev A. P. , Vanyunina V. V.
Published: April 2021

Experimental toxic hepatitis was induced by single administration of Acetaminophen ( paracetamol) in a dose of 1000 mg per 1 kg of body mass in Wistar rats. Inflammation pathology was modeled by wounding the upper maxilla gingiva in toxic hepatitis rats on the 6-th day. Intact rats were controls. On the 1-st and 7-th day, ratio of neutrophil-macrophag was determined in smears of the upper maxillas gingival, oxygen-dependent functional activity of neutrophils was assessed based upon HST-test, functional activity reserves were assessed by the stimulation index. On the 7-th and 13-th day, alaninaminotransferase and aspartataminotransferase activity, level of general and indirect bilirubin, general blood protein were assessed in blood serum of these rats. Toxic hepatitis was established to be accomplished by increased biocidity of phagocytes, decreased functional reserves of neutrophils and their migration into the parodontium. In experimental inflammation, suppurative processes in parodontium tissues are revealed in toxic hepatitis rats by 1.5 times less than in controls due to lower biocide activity of phagocyte cells and increased migration of macrophages.
Hygienic assessment of minimal set of provisions which constitute consumersbasket for main social-demographic groupsof the Tomsk region population
Authors: Volkotroub L. P. , Novatnay Ye. A. , Laskeyeva N. I.
Published: April 2021

Hygienic assessment of five minimum sets of provisions which constitute consumers basket (mean model of nourishment of mean-statistical inhabitant of the Tomsk region of definite social-demographic group) was performed. Number of chemical substances (proteins, fats, carbohydrates, vitamins, mineral substances) which constitute provisions structure was calculated. Hygienic assessment was performed by comparing the calculations obtained with the norms of physiologic needs in provisions and energy for several population groups. The given model can be used for calculation of living wage as the model which provides healthy nourishment , meets physiologic needs of the organism in nourishing substances and energy at minimum cost of the provisions.
Influence of biologic aging rate and arterial hypertension formon cerebral flow condition in aged and senile patients
Authors: Golovanov Ye. D. , Maslov N. N. , Nakoryakova Ye. V. , Osipova T. V. , Kozheko S. N.
Published: April 2021

Results of cerebral hemodynamics condition assessment in dependence on central hemodynamics and biological aging rate are given in the article. Peculiarities of blood flow which influence on the development of chronic brain ischemia and mechanisms of its cellular compensation are revealed.
Experimental study of inclusion expediency of the white willow extractin the hydrogel of anti-arthrosis action
Authors: Kompantsev D. V.
Published: April 2021

The analysis of acute toxicity and anti-inflammation activity of the willow extract is performed expediency of its inclusion in the preparations with anti-arthrosis activity. The dose dependent study of anti-inflammatory activity of willow extract was carried out of the model of acute inflammatory swelling which was provoked by introduction of 0.1 ml of 10% kaolin in the hind leg of the rat. Comparative anti-inflammatory activity of glucosamine sulphate and hydrogel in experimental osteoarthrosis was studied by modeling of inflammation. Most marked anti-inflammatory activity was shown to have the willow extract in the doses of 100 and 200 mg/kg. Inclusion of the willow extract in granules increased anti-proliferative activity of glucosamine in experimental osteoarthrosis. Combined use of the willow extract with glucosamine more effective than monotherapy by glucosamine, influenced suppressively on proliferative stage of inflammation in experimental osteoarthosis.
Macro- and microelements of blood mononuclear leukocytes in patients withpulmonary tuberculosis
Authors: Novitsky V. V. , Strelis A. K. , Ourazova O. I. , Shilko T. A. , Tkachenko S. B. , Yesimova I. Ye. , Voronkova O. V. , Serebryakova V. A. , Filinyuk O. V. , Ivanova Ye. V. , Baranova O. V.
Published: April 2021

In article the results of the analysis of changes of the contents macro- and microelements (К+, Ca2+, Fe2+, Cu2+, Mn2+, Zn2+, Mg2+, Al3+) in lymphocytes and monocytes of peripheral blood in patients with infiltrative drug-sensitive and drug-resistant pulmonary tuberculosis before and on a background of realization standard antituberculosis therapy are discussed
Haematoretinal barrier reaction on combined exposure of ionizing radiationand bright light
Authors: Potapov A. V. , Varakuta Ye. Yu. , Logvinov S. V. , Zhdankina A. A. , Mikhoulya Ye. P. , Anikina Ye. Yu.
Published: April 2021

The aim of this work was to determine character of modifying radiation influence on damages of haematoretinal barrier components which is caused by light. The study showed that preliminary total x-ray radiation (5 Gy) increases lightning damages (3 500 lx, on the 1-st, 2-nd, 7-th, 14-th, 30-th days) of haematoretinal barrier which manifest by decreased specific square of chorioideas open capillaries, by haemodynamic disorders, reactive and destructive changes of pigmental epithelium. Damages of haematoretinal barrier is of focal character and are mostly l expressed on the areas of retina with massive destruction of neurosensory cells.
Structural and metabolic status of erythrocytes in patients with juvenile uterinebleedings
Authors: Sotnikova L. S. , Shevtsova N. M. , Zhdanov V. V. , Yevtushenko I. D. , Bolotova V. P. , Sidorova M. M.
Published: April 2021

Study results of investigation of peripheral erythron component in patients with juvenile uterine bleedings. We found marked changes of metabolic and morphologic status of erythrocytes: decreased mean mass of their dry weight and increased number of their transformed and degenerative forms. Cytochemical studies registered decreased content of sulfa radicals and lipoproteins in cytomembranes of erythrocytes. The most marked change of peripheral erythron component was seen in yuvenile uterine bleedings which are ongoing in the setting of high plasma estrogen level.
The condition of colonization resistance in surgical patientsearly after the surgery
Authors: Chebotar’ A. B. , Choubik M. V. , Krasnozhenov Ye. P. , Dambayev G. Ts.
Published: April 2021

We have examined one of the main components of the mechanism of purulent-inflammation complications in surgical patients. It is normal microflora which reflects the condition of colonization resistance of the organism which is a leading mechanism of opposition to hospital infections. We have established changes of microflora of different biotopes of the organism in dependence on pathologic focus localization and of the period after the surgery. Complex approach to the investigation of colonization resistance allowed to discover not only dysbiotic changes but disturbances of some immunological mechanisms of total and local anti- infectious protection in surgical patients. It is desirable to combine selective decontamination with taking drugs which normalize indigenous micro-flora of the host (special diets, growth stimulators of normal microflora representatives, eubiotics) and immune-stimulating therapy.
Nitrosoglutathione and sodium nitroprusside influence on mechanical tensionof smooth muscles of guinea pigs airways
Authors: Diyakova Ye. Yu. , Davletiyarova K. V.
Published: April 2021

Influence on mechanical tension of smooth muscles of isolated segments of bronchi of nitrosoglutathione and sodium nitroprusside on healthy and sensibilized guinea pigs by an ovalbumin was studied in conditions close to isometric, by a method of mechanography. Smooth muscles of airways responded by dilatation under influence of nitrosoglutathione; sensibilization led to depression of relaxing influence of nitrosoglutathione on smooth muscles cells of airways.
Clinic and treatment of bronchial asthma, combined with cardiovascularpathology
Authors: Gordeyeva N. V. , Demko I. V. , Petrova M. M. , Artyukhov I. P.
Published: April 2021

The purpose of research - to study cardiovascular diseases frequency in patients with bronchial asthma (BA), the influence of cardiovascular disease on clinical course and severity of BA, the role of base and symptomatic therapy, to evaluate quality of diagnostics and treatment of cardiovascular disease in patients with BA. The date of patients register BA in Krasnoyarsk (2005) was analyzed - 5 104 patients. The frequency of occurrence of BA with cardiovascular pathology is high and amounts to 88,3%. Small number of patients with severity course of BA - 55%, middle severity stage - 44%, invalidity - 64%. It was revealed, that cardiovascular pathology appears against a background BA. The part of patients with cardial pathology before BA diagnostics had therapy, influenced on hyperactivity and this therapy assisted in forming and worsening of asthma. Base therapy of BA in most cases did not correspond to severity stage of asthma and recommendations of GINA. The absences of symptom control is bound up with unregular research functional lung ability and with insufficient attention to diagnostics and treatment accompanied pathology of cardiovascular organs. Not only adequate therapy but study of patients with the purpose of complex realization of recommendation, decrees of risk factors and treatment of accompanied pathology is necessary for improvement of asthma control, decrease of exacerbation number, unplanned visits of doctor and calls to emergency.
Extra-fascial hemithyreoidectomy
Authors: Malinin D. I. , Petrov V. G.
Published: April 2021

The aim of the study was to improve surgical results of patients having thyroid gland pathology by the development of the surgery method directed to increasing possibility of injury and maintenance of the upper laryngeal nerve integrity. Method of performing extrafascial hemithyreoidectomy with visualization of recurrent nerve, parathyroid gland and upper thyroid artery is presented which is directed to decrease specific complications (vocal fold paresis, hypoparathyreosis) and complications associated with the upper laryngeal nerve injury. Using this method, 166 patients having node pathology of thyroid gland were operated on. This method resulted in decreased number of complications (from 15,0 to 2,6%).
The substantiation of chronic pancreatitis surgical treatment method selection
Authors: Koubyshkin V. A. , Kozlov I. A. , Yashina N. I. , Shevchenko T. V.
Published: April 2021

The experience of surgical treatment of 154 patients having chronic pancreatitis with preferential injury of the pancreas head which underwent different operative interventions: isolated resection of pancreatic head ( based upon Berger surgery - 24, Frey surgery - 39), pancreatoduodenal resection ( with gastric resection - 22, with preserved pylorus - 43) and drainage surgeries - 26 is presented in the article. The surgery of isolated resection of pancreatic head has less number of nearest unfavorable results compared with pancretoduodenal resection with preserved pylorus. Proximal resection of the pancreas the variants of which are different isolated resection of pancreatic head is superior upon surgeries with full or partly resection of the duodenum due to fast normalization of the motor-evacuation function, less rate of the intestinal reflux and portion character of duodenal evacuation. In the follow-up period after pancreatoduodenal resection, atrophic processes occur in distal areas of the pancreas which are followed by clinical manifestations of exo- and endocrinous insufficiency. The surgery of longitudinal pancreatic jejunostomy does not avoid pathologic changes in the organ head and pain syndrome.
Cystic duodenal dystrophy. Typical case as an example of diagnosticsand surgical tactics
Authors: Yegorov V. I. , Koubyshkin V. A. , Karmazanovsky G. G. , Schegolev A. I. , Yashina N. I. , Stepanova Yu. A. , Solodinina Ye. N. , Izmailova N. S.
Published: April 2021

Duodenal dystrophy, a chronic inflammation of the aberrant pancreatic tissue in the duodenal wall, is a relatively rare disease in the practice of physicians. The heterotopic pancreas is usually functioning, and the development of acute and chronic pancreatitis in it is even more probable than in the orthotopic gland as a result of an underdeveloped duct system. The progression of ectopic pancreatitis associated with increasing cystic formation could lead to a blockade of the major or minor duodenal papilla and subsequent chronic pancreatitits in the pancreas proper. Furthermore, a malignant transformation of the aberrant pancreas is not a rare occurrence. It is essential to carry out a timely and sharp diagnosis of this condition as it often defines the surgical tactics. The purpose of this report is to present a typical case of cystic duodenal dystrophy.
The surgery of azygoportal separation in esophageal varicosis
Authors: Zherlov G. K. , Zherlov T. G. , Koshevoi A. P. , Karpovich A. V.
Published: April 2021

The original techniques of the separation surgery in the system of portal and azygos veins in patients having portal hypertension and esophageal varicosis with recovery of the valve apparatus in the area of gastroesophageal junction is offered in the article which allows to avoid the development of reflux-esophagitis and recurrence of esophageal bleeding in the postoperative period.
History of hepatic surgery development
Authors: Yermolov A. S. , Chzhao A. V. , Chougounov A. O.
Published: April 2021

Data concerning history of hepatic surgery beginning from the Middle Ages to current days are presented. On the first stage (till XIX century), representatives of medical profession had schematic ideas on hepatic anatomy and operations on this organ were perforemed sporadically. On the second stage (first half of the XX century), segmental hepatic anatomy was established, different technical methods concerning identification of shared and segmental pedicles were offered. Planned resections of the liver began to be regularly performed in this period. Current, third stage of the surgery development was marked by the synthesis of achievements in the area of hepatic anatomy and surgery with revolutionary discoveries in high technology area, immunology, tissue compatibility and pharmacology. Such surgeries became to be possible as transplantation of the liver, broadened resections and extracorporeal interventions performed on the liver.
Induced sputum cytology and nitric oxide in exhaled breath condensatein bronchial asthma patients
Authors: Volkova L. I. , Kapitanova D. V. , Boyarko V. V. , Saprykina E. V.
Published: April 2021

Induced sputum cytology, nitric oxide content in exhaled breath condensate and dynamics of these parameters against the background of glucocorticosteroid therapy were studied in patients with bronchial asthma exacerbation. Sixty four patients with different degree of bronchial asthma were included. The control group was represented by 20 healthy volunteers. It is shown, that monitoring of induced sputum and nitric oxide indices is informative to assess efficiency of anti-inflammatory therapy in bronchial asthma patients.
Clinical-immunological characteristic of clinical remission in children with chronic pyelonephritis after surgical correction of obstructive uropathies
Authors: Pekareva N. A. , Loskutova S. A. , Trunov A. N.
Published: April 2021

.
The clinical aspects of Lyme borreliosis
Authors: Shperling M. M. , Tolokonskaya N. P. , Fomenko N. V. , Romanova Ye. V.
Published: April 2021

The diagnosis of Lyme borreliosis is objective difficult. There are tendention of increasing of patients the age of 51 and older. The characteristics of disease, for example fever at acute time is connected to reactivity in acute diseases in general. On time antibodies detection of patients blood with suspicion of the cronical borreliosis is not criteria of proven disease.
Modeling of the multidrug resistance syndrome in experiment on mice with lymphosarcoma RLS40
Authors: Sen’kova A. V. , Shklyayeva O. A. , Ageyeva T. A. , Zenkova M. A.
Published: April 2021

.
Clinical and laboratory aspects of early diagnostics meningitis and meningoencephalitis induced by tick-borne encephalitis
Authors: Tolokonskaya N. P. , Kazakova Yu. V. , Spiridonova E. A. , Burmistrova T. G. , Provorova V. V.
Published: April 2021

Clinical displays of the early period of meningitis and meningoencephalitis induced by tick-borne encephalitis have significant similarity and can not serve as reliable criteria of weight, the forecast and differential to therapy. Mixed somatic pathology of degenerative nature, which was revealed in the study of the majority of patients with tick-borne encephalitis, more often including the initial central nervous system affliction under conditions of negative changes of organism reactivity, is regarded as one of the main reasons of infection conversion into disease. The virus becomes an aggression factor at such joint biological causes, changing endobiocenosis, which is of great importance for substantiation of curing therapy.
Medicamentous correction of haemostatic system at surgical treatment of hemorrhagic form of ovary apoplexy
Authors: Sirota O. M. , Momot A. P. , Fadeyeva N. I.
Published: April 2021

.
Screening content neurospecific enolase in serum by patient with chronic neurologic disease
Authors: Grebenyuk O. V. , Alifirova V. M. , Zhoukova N. G. , Radzivil T. T. , Gashilova F. F. , Lapina Ye. Yu. , Zhoukova I. А.
Published: April 2021

.
Disbalance of testosterone is a risk factor of the beginning of ischemic stroke of middle age men
Authors: Doronin B. M. , Vas’kina Ye. A. , Denisova O. A.
Published: April 2021

The aim of work is to exposure how disbalance of male sex hormones in the period of the age-specific reorganization affects development of atherosclerosis and vascular disorders by the example of ischemic stroke, establishment of correlation between hormonal dysfunction by the example testosterone and lipid metabolism according to the somatic type in the critical period of ischemic stroke. The pilot analysis of level of sex hormones by the example testosterone, lipids and body mass index confirms that there is correlation between these indices. Rising of body mass index is accompanied by reduction of sex hormone concentration, but for all that levels of cholesterol and atherogenic fraction are increased.
L.I. Omorokov and his role in the formation of Kozhevnikov’s epilepsy doctrine
Authors: Mukhamedzyanov R. Z. , Bogdanov E. I.
Published: April 2021

.
Experience of induction of immune tolerance in patients with inhibitor form of hemophilia A in the presence of negative prognostic factors
Authors: Zozulya N. I.
Published: April 2021

.
Symptoms of neck and pectoral osteochondrosis with bening illuess of mammaru
Authors: Polecshuk N. V. , Аlifirova V. M.
Published: April 2021

.
Versions of polymorphous changes in р53, XRCC1, and XPD genes in children with acute lymphoblastic leucosis
Authors: Kaznacheyev K. S. , Belyavskaya V. A. , Lyakhovich V. V. , Pospelova T. I.
Published: April 2021

.
Role of resident macrophages in mechanisms of cells proliferation and cancerogenesis
Authors: Panin L. Ye.
Published: April 2021

.
Value of constitutional polymorphisms gene р53 at patients with non-Hodgkin’s lymphomas
Authors: Pospelova T. I. , Voyevoda M. I. , Voropayeva Ye. N. , Belyavskaya V. A. , Kovynev I. B. , Berezina O. V.
Published: April 2021

.
Genetic polymorphism of haemostatic system in patients with venous disfunction at mesenchimal dysplasia
Authors: Kotovschikova Ye. F. , Buyevich Ye. I. , Kulikov V. P. , Chudimov V. F. , Pen’kova Ye.
Published: April 2021

.
Value of clinical attributes and their combinations in early diagnostics of the clinical form of tick-borne encephalitis
Authors: Provorova V. V. , Tolokonskaya N. P. , Spiridonova E. A. , Kazakova Yu. V.
Published: April 2021

Questions of early forecasting of character of current of tick-borne encephalitis and as investigation differential the approach to therapy in the first days of illness remain one of the sharpest problems. Comparison of the revealed clinical and laboratory criteria in allows essentially to expand opportunities of definition of weight and the forecast of this infection.
Detection of antibodies against agents of human granulocytic anaplasmosis and human monocytic ehrlichiosis serum from patients from Novosibirsk Region
Authors: Rar V. A. , Fomenko N. V. , Mel’nikova O. V. , Chernousova N. Ya.
Published: April 2021

Serum samples from patients hospitalized with febrile illnesses occurring after tick bites were investigated for antibodies against agents of human granulocytic anaplasmosis (HGA) and human monocytic ehrlichiosis (HME). Ten from 205 patients were shown to contain HGA-specific antibodies, one patient — HME-specific antibodies, and one patient — both antibodies against agents of HGA and HME. Diagnosis of HGA was serologically and clinically confirmed for four patients. All patients with serologically confirmed HGA were shown to contain also antibodies againstBorrelia burgdorferisensu lato or HME-specific antibodies. Moreover, one patient was shown to be infected with tick-borne encephalitis virus. Thus, it seems reasonable to analyze patients with confirmed tick-borne encephalitis as well as with febrile illness after tick bites on the infection with HGA and HME.
The analysis of survival of the patients with lymphoproliferative desorders at presence or lack of the myelodisplasia
Authors: D’yachkova N. Yu. , Pospelova T. I. , Kovynev I. B. , Obgolts Yu. N.
Published: April 2021

.
Skin cancer incidence rates in Krasnoyarsk Region
Authors: Ruksha T. G. , Dettsel A. Ye. , Salmina A. B. , Taksanova Ye. I. , Dettsel K. A.
Published: April 2021

Skin cancer is one of the most common malignancies and its increasing rates are found all over the world and in the Russian Federation in particular. The paper presents statistical analysis of the data on skin cancer morbidity and mortality rates in Krasnoyarsk Region summarized for the period since 1999 until 2005. Peculiarities of occurrence of this pathology among male and female persons are evaluated, tendencies of epidemiology of these tumors are analyzed, and comparative analysis of skin cancer morbidity in Krasnoyarsk Region with the Russian Federation as a whole and with foreign countries is carried out.
Influence nanoparticles on morphology of internal organsof the mouse at intravenous introduction of a solution nanopowder Fe3O4
Authors: Milto I. V. , Mikhaylov G. A. , Ratkin A. V. , Magaeva A. A.
Published: April 2021

The influence nanoparticles Fe3O4 on morphology of the vital organs of the mouse after unitary intravenous introduction of a solution nanopowder Fe3O4 has been investigated. Change of morphology of the studied organs has been established, it testifies about adaptive reactions of an organism of mice to intravenous introduction nanopowder which outcome at the given stage is difficult for predicting.
HLA antigens in syphilis patients in Tuvinian population
Authors: Obukhov A. P. , Prokhorenkov V. I. , Pospelov L. Ye. , Karacheva Yu. V.
Published: April 2021

have examined 133 healthy donors, 41 syphilis patients with symptoms, and 45 patients with early latent syphilis. All the examined persons were grouped by class I HLA antigens using the standard microlymphocytotoxic test. In syphilis patients, as compared to healthy persons, the frequency of HLA antigens A3, B17, and B40 was increased, while the frequency of B5 was decreased. In syphilis patients with symptoms, HLA antigens A3, B7, B17, B40 and HLA haplotypes A3B17, A3B40, A9B7 were observed with increased frequency. At the same time, in patients with early latent syphilis, HLA antigens A1, Cw3, B8, B17 and HLA haplotypes AB17, A9B8 were observed with increased frequency, while HLA antigen B5 occurred with decreased frequency. The influence of HLA antigens on occurrence of different forms of syphilis is discussed.
Supporting fundamental researches of the scientists of SSMU
Authors: Zakharova G. V. , Shebalkina I. Ye. , Rudko T. V. , Goltsova I. A. , Kharitonova Ye. M.
Published: April 2021

In the article the information about Springer and World Scientific Co. Pte. Ltd. databases is presented. The access to these databases is opened for all users of the scientific medical library of SSMU in 2008. The access to the full-text resources became possible because the projects of Russian Foundation for Basic Research were being carried out in SSMU.
Nutritional insufficiency in patients having chronic obstructive pulmonary disease
Authors: Beloborodova E. I. , Akimova L. A. , Burkovskaya V. A. , Semenenko Ye. V. , Asanova A. V.
Published: April 2021

Absorption function of small intestine concerning fats, proteins, carbohydrates in 68 patients having chronic obstructive pulmonary disease (COPD) was studied in comparison with trophologic insufficiency. Thirty five patients were controls. Absorption was studied based upon van de Kamer method, by radioisotope method and d-xylose test. Decreased absorption was revealed in patients with mean severe and severe COPD. Direct correlations were established between body mass deficiency in COPD patients and decreased absorption function of the small intestine as concerns proteins (r = 0,71), fats (r = 0,55) and carbohydrates (r = 0,48).
Features of the apoptosis markers expression by skin cell with ageing
Authors: Vitruk T. Yu. , Ryazantseva N. V. , Pesterev P. N. , Mustafina L. R.
Published: April 2021

The immunohistochemical study of skin was conducted to verify presence of p53, bcl-2 and bax apoptosis markers in epidermal keratinocytes of patients from two age groups: 16 to 44 years old and 45 to 64 years old. It was discovered that with chronological ageing of skin the expression levels of p53 and bax apoptosis markers are raised by epidermal cells in patients of elder age group. Obtained data testifies to cumulative damaging effect of a quantity of proapoptotic factors (oxidative stress, UV-waves, ionizing radiation, chemical reagents etc.) on epidermal cells with ageing.
The main features of treatment in patients with iron deficiency anemia, which isa consequence of juvenile uterine bleedingwith chronic opisthorchiasis
Authors: Yevtushenko I. D. , Sidorova M. M. , Sotnikova L. S. , Dygai A. M.
Published: April 2021

This article is presented whith the results of comparing assessment of clinical efficiency and medicine portability. This medicine is a stimulator of hematopoiesis (poetam-medicine which contains affinno refined antibodies to human recombinant erythropoietin). Besides there were rep resented the results of treatment with iron-containing medicine (Sulfate of iron 325 mg) which helps in case of anemia which is a consequence of juvenile uterine bleeding in puberty.
The experimental substantiation of the treatment of transverse (central) acetabular fracture with femoral head subluxation by transosseousosteosynthesis method
Authors: Shevtsov V. I. , Irianov Yu. M. , Silantiyeva T. A. , Kochetkov S. Yu.
Published: April 2021

The aim of this work was to study the roentgen-and-morphological dynamics of reparative regeneration for the experimental substantiation of treating a transverse (central) acetabular fracture with femoral head subluxation by the method of transosseous osteosynthesis. Experiments were performed using 11 mongrel dogs, both males and females. It has been established that after setting a femoral head into the acetabulum, precise reposition and fixation of its fragments the bone union in the fracture site is achieved within 35—65 days.
Investigation of the bone density in multiple sclerosis
Authors: Dranichnikova O. S. , Zavadovskaya V. D. , Alifirova V. M.
Published: April 2021

A number of investigations revealed a problem of osteopenic syndrome in patients with multiple sclerosis but there is no common opinion concerning factors which lead to its development. We observed 65 patients with multiple sclerosis with various type of its course and disability status of several degree based upon EDSS scale. Ultrasound osteometry of the calcaneus, computer tomography of QCT of L1—L3 vertebras were performed, serum crosslaps, N-MID osteocalcin were used. Decreased bone density, injured bone microarchitectonics and suppression of bone formation and resorption, which were correlated EDSS were found. Correlations with other factors (growth, weight, gender, and number of steroid therapy sessions ) for these parameters was not revealed. This allowed to conclude that the main reason of decreased bone mass in patients with multiple sclerosis is the dramatic decrease in physical activity.
Change of differential diagnosis tactics in the process of clinical observation ofa patient
Authors: Kalinina O. V.
Published: April 2021

The complicated ratios of clinical symptoms of internal lesions during central lung cancer are demonstrated in the article when changes of differential diagnosis tactics were required for diagnosing that necessary keeping is priority of the clinical appraisal of the results inspection patient.
Efficiency of assotiated radonotherapy in rehabilitation of patients with posttraumatic osteoarthritis
Authors: Udartsev Ye. Yu. , Raspopova Ye. A. , Rekhtin N. F. , Lavrinenko S. I. , Leonov Ye. N.
Published: April 2021

Results of treatment of 103 patients with posttraumatic osteoarthritis complicated secondary synovitis of knee and ankle joints are presented. Rehabilitation programs in comparising grops included the treatment by common aquatic radon baths, their comdinations with magnetic-lazer therapy, assotiation common radonotherapy and local a-therapy by radon applicator for external use. Comparatively analyzed of treatment results demonstrated high efficiency of assotiation local and common radonotherapy such as decrease activity of inflammation, reduction exudative and proliferative disorders in joints.
Efficiency of recovery of endometrium after legal abortion at extracorporal antibiotic prophylaxis
Authors: Tikhonovskaya O. A. , Fokht O. M. , Logvinov S. V.
Published: April 2021

The purpose of this study was to estimate the efficiency of preventive maintenance of postabortive complications by infusion of autogenic cefamizine-loaded blood cells and use of oral contraceptives and Polyoxidonium» Clinical estimation, ultrasonography, biopsy and immune coloring with progesterone and оestradiolum receptors in 35 women with the proposed method and 35 women with the standard method was used. It was revealed that application of the proposed method favored restoration of endometrium steroid receptors. As a result, the proposed method favors preservation of the reproductive function in women to a greater degree than the traditional method does.
Role of protein kinases JNK and p38 in regulation of mononuclear leucocytes apoptosis in oxidative stress
Authors: Chasovskikh N. Yu.
Published: April 2021

Programmed cell death of peripheral blood mononuclear leucocytes taken from healthy donors and cultivated with various concentration of Н2О2, selective inhibitors of JNK (SP600125), 38 (ML3403) and in case of pneumonia was investigated. Intensification of intracellular production of reactive oxy р МАРК - gen species was accompanied by the increase in number of apoptotic and TNFR1-presented cells and mononuclears with reduced value of mitochondrial transmembrane potential in a case of oxidative stress induction with 1 mM hydrogen peroxide and in blood taken from patients with pneumonia. Action of inhibitors SP600125 and ML3403 in vitro in oxidative stress conditions prevents the increase in number of annexin- positive mononuclear cells, that confirms the participation of JNK and 38 -kinases in mechanisms of oxidative stress-mediated apoptosis dysregulation.
Psychosomatic relations in gastro-intestinal diseases in therapeutic practice
Authors: Kartashova I. G.
Published: April 2021

We have studied peculiarities of psychosomatic relations in 140 duodenal ulcer (DU) and irritable bowel syndrome (IBS) patients having neurotic and psychic disorders. Analysis of results of clinical-endoscopic, clinical- psychopathological, and psychological methods has revealed polymorphism of psychopathological disorders hampering differential diagnostics and treatment of DU and IBS. This requires a combined approach to therapy of comorbid gastro-intestinal and borderline mental pathologies with both somatotrophic and psychotropic agents.
Effect of Granotsit preparation on mesenchymal bone marrow stem cells in experimental model of secondary immune deficiency with the aid of cyclophosphan
Authors: Baikov A. N. , Shakhov V. P. , Shelgaev N. Yu. , Serebryakova V. A.
Published: April 2021

Experiments with 60 male and female mice of Balb/c line with mass of 18—21 g have been carried out. All manipulations, including ether euthanasia, were performed within the framework of approved rules for experiments with experimental animals. The mice were divided into four groups each of 15 animals. The groups were injected with physiological salt solution (first group), cycliphosphan (second group), Granotsit preparation (recombinant granulocytic colony-stimulating factor) (third group), and cycliphosphan in Granotsit preparation (fourth group). We have studied the total number of leucocytes in blood, bone marrow cellularity, content of granulocytic- macrophage colony-forming cells and mesenchyma l precursors with the aid of tissue culture in vitro. It has been found that the Granotsit preparation can stimulate myelopoiesis (direct specific action) and mesenchymopo iesis (indirect action) in norm. When a cytostatic agent, the studied cytokine has a protective action on both myeloid and mesenchyma l precursors of bone marrow.
System of x-ray methods in diagnostics of maxillofacial traumas
Authors: Vasilyev A. Yu. , Lezhnev D. A.
Published: April 2021

A maxillofacial trauma is one of the most frequent traumas with the permanent tendency to growth. Such victims usually fall in the category of serious patients, since traumas of facial bones are often accompanied by injuries of organs of vision, brain, and accessory sinuses. Physical examination usually fails to provide complete information on the character and extent of facial injuries. X-ray diagnostics should solve several problems: refinement or verification of clinical diagnosis, determination of medical prognosis, help in development of optimal treatment tactics, and others.
Evolution of maximum permissible doses of ionizing radiation and role of accident of 1993 at the Siberian Chemical Plant in irradiation of people
Authors: Tetenev F. F. , Ryzhov A. I. , Porovsky Ya. V.
Published: April 2021

In April 2008, it was 15 years after the accident at the radiochemical line of the Siberian Chemical Plant (SCP). Changes in the ionizing radiation background due to the accident of 1993 and results of investigation of the radiation situation in the SCP coverage zone are described. The data on state of health in people leaving in the zone of radiation track of the accident are ge-neralized. The results of our investigation are presented.
History of development of reconstructive-restorative surgery (50-years experience of the Clinic of General Surgery at the Siberian State Medical University)
Authors: Deryugina M. S. , Dambayev G. Ts.
Published: April 2021

The paper describes, in historic aspect, the main stages of development of reconstructive-restorative surgery and 50-year experience of application of polymer materials if the Clinic of General Surgery at the Siberian State Medical University (Tomsk) (1958—2008). The results of experimental investigations of polymer plastic, suture, and glue materials of different construction and chemical structure are analyzed. For the first time, the state (chemical structure and biological stability) of implanted Russian lavsan and polypropylene have been studied in 59 patients after a long (up to 33 years) period in human organism. Explantants of a new construction and methods of hernioplasty have been developed. More than 5000 polymer-plastic operations have been made in patients with difficult forms of the hernial disease.
The foundation of the systematic reserve’s doctors training in Tomsk: the history of the growth
Authors: Ronzhin S. G. , Nekrylov S. A.
Published: April 2021

The current project of the resources security system the modern Russian Armed Forces is characterized by radical modifications in the sphere of a train the reserves for their mobilization. In the frames of this called direction more than eighty years medical service reserve’s officers training stage is completed in all higher medical schools. It makes sense in indicated tendency remind about some chief events in the history of the military and disaster medicine chair of the Siberian state medical university and about its some personalities.
Daily rhythm of blood pressure at patients with autoimmune thyreoiditis depending on function of the thyroid gland
Authors: Kravets Ye. B. , Idrisova Ye. M. , Latypova V. N. , Davaasuren Damdindorj
Published: April 2021

The purpose of research was to give the comparative characteristic of a daily profile and circadian rhythm of blood pressure at patients with autoimmune thyreoditis depending on function of a thyroid gland. 66 patients with autoimmune thyreoditis and 25 healthy examinees participated in research. The received results testify that the daily rhythm of arterial pressure at patients with autoimmune thyreoditis authentically depends on the functional characteristic of a thyroid gland. Infringements of circadian rhythm of systolic blood pressure «non-dipper» and excessive decrease of diastolic blood pressure at night are characteristic for patients with autoimmune thyreoditis.
The express-diagnostics of versions of a DIC-syndrome in trauma and acute haemorrhage patients
Authors: Ripp Ye. G. , Shipakov V. Ye. , Shpisman M. N.
Published: April 2021

The research of a haemostatic system in trauma and acute haemorrhage patients by a new instrumental method — haemocoagulographia — allows at early stages of disease to reveal patients having the tendency to development haemostatic anomalies, Multi Organ Dysfunction Syndrome and failure of disease, that increases accuracy of an evaluation of weight of a condition and prognosis on APACHE-III system (Acute Physiology And Chronic Health Evaluation).
Clinical peculiarities of depressive disorders in patients with malignant gastrointestinal tract tumors
Authors: Kornetov N. A. , Zhorov V. A.
Published: April 2021

Unipolar depression is prevalent in inpatients with GIT tumors. Following types of depressions have been distinguished: with cognitive disturbances, anxious-hypochondriac and agitated ones. For oncologists and surgeons clinical symptoms of high likelihood of depressive disorder in oncological pathology of GIT are as follows: pain, disturbance of quality of sleep, experienced weakness and breakdown, experienced fear, tension and sudden panic with agitation.
Morphofunctional characteristics in men of middle and elderly age with ischemic stroke
Authors: Denisova O. A.
Published: April 2021

Morphofunctional characteristics of men of middle and elderly age with ischemic stroke have been studied. It has been shown that severity of disease is explained, among other causes, by augmenting of dishormonal disorders in patients.
Some changes of psychologic status of patients having multipled sclerosis
Authors: Alekseyenko Ye. V. , Sysoyeva O. S. , Smagina I. V. , Fedyanin S. A.
Published: April 2021

There are psychologic status of patients having multipled sclerosis research results. 30 patients were involved in the research, among them there were 18 (60%) female and 12 (40%) male ones at the age between 20 and 60. Patient examination was realized by means of the Spielberger, Maudsley and Zung methods. As a result of research there are patient's psychological state changes. 66% of patients have these changes in the form of high-grade uneasiness, 50% — in the form of rigidity and introversion, 83% have depressing disorders in the form of slight depression and subdepression.

These findings expand our conception about psychological mechanisms of dissociated personality patients with multipled sclerosis have, and need various multimodal approaches for their psychological correction.
Clinical and functional changes of condition of patients with ischemic stroke during rehabilitation programs
Authors: Doronin B. M. , Popova T. F. , Klimova L. A. , Kornach N. V. , Shtobbe A. A. , Popov M. V.
Published: April 2021

The complex rehabilitation programs make an impact on physical, psychological and social aspects of quality of life of the patients with acute brain stroke. The sanatorium stage of treatment is a great important because there are a lot of harmonious combinations of drugs, psychosociological, natural and physiotherapeutic methods of influence on human body.
Influence of ishemic stroke on changes of parameters of heart rate variability and clinical-echocardiografical parameters in patient with chronic heart failure in the early recovery period
Authors: Doshchannikov D. A. , Mokina T. V.
Published: April 2021

The purpose of present research is to estimate the influence of ischemic stroke on changes of clinical and instrumental parameters in patients with chronic heart failure (CHF) depending on expressiveness of neurologic deficiency. We supervised 103 patients with CHF, among them 71 patients with stroke. In all the patients twice heart rate variability and echocardiography were carried out. To determine CHF FC we used an estimation scale of a clinical condition (SHOCKS by Mareev, 2000). After 6 months all the patients were divided into 2 groups depending on expressiveness of neurological deficieny. Significant deterioration of heart rate variability (HRV) parameters in the group of patients with expressed neurological deficiency was revealed. Also in this group increase of end diastolic volume, end systolic volume and deterioration of diastolic function was revealed. 6 months after stroke in patients with CHF with expressed neurological deficiency reduction of parameters of HRV, progressiveness of hyperactivity of sympathetic adrenal system, deterioration of morphological-functional parameters of left ventrical was revealed.
Polymorphism of a gene IL12B in patients with multiple sclerosis and healthy persons
Authors: Alifirova V. M. , Orlova Yu. Yu. , Titova M. A. , Cherdyntseva N. V. , Nikolayeva T. N.
Published: April 2021

We examined of 62 patients with various types of multiple sclerosis current, which middle age has made (31,8 ± 1,2) years. It has been lead genotyping by means of PCR by a polymorphic variant 1188A/С gene IL12B in 3`-not broadcast area and has been found out not only higher frequency of alleles C of a gene IL12B in comparison with healthy persons, but also the association with more active of MS current is revealed. At the analysis of immunological parameters of patients depending on a genotype IL12B, it has been found at carriers alleles C the tendency to reduction absolute maintenance of mature T-lymphocytes and increase CD25+ and CD95+.
Headache and hypothalamic syndrome
Authors: Zhestikova M. G. , Schmidt I. R. , Shakhvorost N. P.
Published: April 2021

We have carried out a comparative analysis of peculiarities of headache at patients with adenoma of hypophis and hypotolamic syndrome of complicated genesis. 611 sick people were checked up (472 females and 139 males): 311 with adenomas of hypophis and 300 with hypotolamic syndrome. Methods of investigation: for appreciation of headache we analyzed qualitative and spatial — temporary descriptions and provokating factors. Double-sided headache at parients with adenomas of hypophis was in 2,5 more often than at patients with hypotolamic syndrome. Correlation of frequency of left- and right-side localization was also different: 1,6 : 1 — at sick people with hypotolamic syndrome and 1 : 1,1 — with adenomas of hypophis.
Cognitive disorders and life quality of parkinsonism patients
Authors: Zhoukova I. A. , Zhoukova N. G. , Alifirova V. M. , Gashilova F. F.
Published: April 2021

Quality of life is a new characteristic of health of patient, and efficacy of treatment. Quality of life had wide dissemination during last time. The aim of study was to exanimate and to compare quality of life patients with Parkinson’s disease which depended on gender, age, form of disease and cognitive impairment. We examined quality of life of 90 patients with Parkinson’s disease by questioner SF-36 and PDQ-39. Quality of life increased in patients with Parkinson’s disease, and depends from form and cognitive impairment.
Epidemiologica and factors risk of stroke in Kemerovo
Authors: Kovalenko A. V. , Gileva O. A.
Published: April 2021

The paper presents the results of the first prospective epidemiological study of stroke in Kemerovo. The stroke was primary in 77,1% patients, the second one was in 22,9% patients. The frequency of the development of stroke increased with the years. The most prevalent risk factor was arterial hypertension which was recorded in 91,6% patients. Cardiac pathology as a stroke risk factor ranked second (61,7%). Cerebrovascular disorders in close relatives were registered in 55,5% patients. One-month lethality was 41,1%.
Gluten migraine
Authors: Kopishinskaya S. V. , Gustov A. V. , Repin A. A. , Bidnaya I. S. , Belova O. A.
Published: April 2021

Coeliac disease (CD) has been associated with various neurological disorders, the most common being neuropathy, ataxia and migraine. The aims of the present study were to assess the following: 1) the prevalence of migraine in patients affected by CD and 2) the effects of a gluten free diet in CD patients with migraine. 376 patients with CD had direct interviews and full physical and neurological examinations. The diagnosis of migraine was based on criteria of the IHS in 1988. The diagnosis of CD was confirmed endoscopically and by serum IgG antitransglutaminase (TgA) and IgA antiendomysia (EmA). Control group consisted of 234 patients suffering from reflux-esophagitis. The diagnosis was confirmed endoscopically. A gluten free diet was started in the patients diagnosed with CD associated with migraine, who were followed for 6 months. Migraine occurred in 161 (43%) of the 376 patients studied and in 25 (11%) of the 234 control group patients. An increased prevalence of migraine was observed in the coeliac patients. A gluten free diet may lead to an inprovement in the migraine in these patients.
Organization of children epileptological service in Tomsk Region
Authors: Krayeva L. S. , Alifirova V. M.
Published: April 2021

This article shows the analysis of working of the child epileptological room for 2002—2007. The goals of the room are determinate, the groups of the children, examined in the room and being registrating, are selected. Learning the example of 650 children with epilepsy, who are registrating, we found out the domination of focal symptomatic or probably symptomatic form (62,2%). Idiopathic generalized epilepsies made 13,3% with predominance of child absence epilepsies — 39,8%. Epileptic encephalopathy made 3,46% with predominance of West syndrome — 64,3%. In treatment monotherapy were used in 75% of cases, the polytherapy took 25%.