bluuebunny/crossref_metadata_2025 huggingface dataset:
Management of Strategic Changes of the Enterprise in the Context of Long-Term Development of Domestic Companies During the Wartime and in the Post-War Period
Authors:   Poltava University of Economics and Trade, Lozova Oksana V. , Kyzhel Nataliia L. ,   Poltava University of Economics and Trade, Kuzhel Oleksandr V. ,   Poltava University of Economics and Trade
Published: November 2024

The article examines changes as an integral part of the management system of any company. It is defined that not all changes have an impact on the enterprise development strategy. Most of the changes are ongoing and do not affect the activities of the entire company, and therefore require significantly fewer financial and human resources to adapt to them. In an uncertain environment, companies must be prepared for rapid strategic changes, including revising the business model, improving business processes, optimizing costs, and introducing new digital technologies to increase efficiency and reduce dependence on external factors. The key aspect is the company’s personnel: supporting and developing employees through training, motivation and involvement in the change process. The war has affected HR policies, forcing companies to relocate employees to safe regions, implement support programs, adapt recruitment, and ensure open communication. Regular monitoring of the implementation of the strategy and evaluation of results allow you to make timely adjustments and achieve your goals. It is identified that it is strategic changes that require an effective mechanism and a precise algorithm for implementation. It is underlined that during the wartime and in the post-war period, the approach to the development of a long-term development strategy should change significantly, which, in conditions of uncertainty in the external environment, is influenced by many negative factors that create inefficiency of its implementation in the future. In times of war, companies can sacrifice short-term profits, poor product quality, outdated technology, unnecessary costs, old business models, and short-term goals to invest in innovation, raise quality standards, adopt new technologies, optimize costs, transition to new business models, and focus on long-term goals to ensure sustainability and competitiveness. During the wartime and in the post-war period, the long-term development strategy of domestic companies should be based on the principles of diversity, flexibility, and adaptability.
Conceptual Provisions of Management Modeling in the System of Strategic Management of Enterprise Development
Authors:   Lviv Polytechnic National University, Ivaniuk Ulana V. , Halaz Lina V. ,   Lviv Polytechnic National University
Published: November 2024

The article updates the issue of ensuring the stable functioning and development of economic entities on the basis of proper strategic management, planning and modeling in the system of strategic business management. The aim of the study is to generalize and further develop the conceptual foundations and provisions of management modeling in the system of strategic management of enterprise development. It has been proven that in order to guarantee stable long-term functioning, enterprises and organizations should use management modeling tools in the system of strategic management of the development of the economic entity. It is found that the main subjects of management analysis are strategic goals and tasks, in particular for key functional areas of business: finance, marketing, production, commercial and sales activities, personnel management, investments, innovations, etc. As noted in the study, this is a compromise between ensuring adequate financial stability, liquidity and solvency, a high level of profitability, rentability, capitalization and reinvestment, on the one hand, and meeting the main requirements and needs of consumers of products (goods, works, services), on the other hand. It is determined that the quality toolkit of management modeling in the system of strategic management of the development of the business entity in terms of finance and marketing involves the management of financial goals and objectives, financial variables, decisions in the field of marketing and logistics, expectations of buyers, marketing objectives. It is summarized that strategic orientations and objectives serve as a starting point during planning, forecasting, modeling of important parameters – criteria for stable functioning and development of the economic entity. In turn, the leading aspects of the organization's development strategizing are determined using management modeling tools. It is pointed out that the promising direction of further research in this area is the improvement of the methodology of analyzing the quality of strategic management of economic entities.
Competitiveness as a Key Factor in Successful Strategic Business Management
Authors:   Simon Kuznets Kharkiv National University of Economics, Druhova Olena S. , Mosumova Ainura K. ,   Simon Kuznets Kharkiv National University of Economics, Dai Bangchun ,   Simon Kuznets Kharkiv National University of Economics, Tong Qian ,   Simon Kuznets Kharkiv National University of Economics
Published: November 2024

This article explores the impact of competitiveness on the effectiveness of strategic business management. The study analyzes the main factors determining a company's competitiveness in the modern market, highlighting their interrelationship with strategic management approaches. A detailed examination of key methods and tools used to enhance competitiveness and ensure sustainable business development is presented. The paper characterizes how strategic management can influence a company's ability to maintain a competitive edge by aligning business processes with market demands. The research identifies innovative approaches and technologies as crucial elements for strengthening competitiveness. A comprehensive set of measures is proposed to improve strategic management, including the integration of digital solutions, process optimization, and the adoption of agile methodologies. The article also discusses the importance of aligning organizational culture with strategic goals to foster an environment conducive to continuous improvement and innovation. Furthermore, the study provides practical recommendations for implementing strategic initiatives aimed at reinforcing the company's market position amidst intense competition. These recommendations emphasize the need for adaptive strategies that can respond to rapidly changing market conditions and consumer preferences. The role of leadership in driving these strategic initiatives and the significance of cross-functional collaboration within the organization are also explored. The article concludes by considering the long-term prospects for further research in the field of strategic management, particularly in the context of ensuring sustained competitiveness. Future studies could focus on the evolving challenges of the global market and the strategies required to navigate these challenges effectively. The importance of continuous learning and the adoption of a proactive approach to strategic planning are underscored as essential for maintaining a competitive advantage in a dynamic business environment.
Formation of Marketing Communications Instruments for the Promotion of Educational Products
Authors:   Civil Aviation Institute of Ivan Kozhedub Kharkiv National Air Force University, Sheviakov Yurii I. , Krasnonosova Olena M. ,   Simon Kuznets Kharkiv National University of Economics, Kononova Nataliia V. ,   Simon Kuznets Kharkiv National University of Economics, Aleksandrova Viktoriia Ye. ,   Civil Aviation Institute of Ivan Kozhedub Kharkiv National Air Force University
Published: November 2024

Modern progress in technological development and the emergence of innovative products in the field of digitalization have contributed to the emergence of new organizational capabilities and instruments in the field of communications. The progress of innovative development in the field of digital technologies opens up wide opportunities for their use for the exchange of information in the field of economic education. The emergence of new digital methods of communication provides wider opportunities for the use of new forms for the exchange of information in the field of education. The aim of the study is to form a instrumentarium of marketing communications for the promotion of an educational product. The emergence of new means of communication as instruments of the educational process creates qualitative changes in the conditions of educational activity. American and English scholars devoted their efforts to studying the theory of public communication, they noted that marketing communications are expanding and covering more and more audiences, thereby developing into integrated communications. An example is the theoretical model of the persuasive act, or the Lasswell model, in which the communication process is presented as an act considering five basic questions: «Who?», «Says what?», «In what channel?», «To whom?», and «With what effect?». This model is considered to be a reflection of the «theory of political propaganda». Taking into account some difference between the orientation of the «theory of political propaganda» and the consideration of the communication process from the point of view of marketing, because it is more complex and multifaceted, an algorithm for building communication is proposed. The provided algorithm for constructing communication, in contrast to the Lasswell model, is more detailed and therefore can be more widely used in various spheres of educational and economic activity, as well as in public life. Modern innovative inventions of online educational platforms contribute to the globalization of the education market. Educational activities go beyond the physical territory through the use of the Internet. The process of globalization of education is accompanied by increased competition among training providers. Among the modern effective marketing activities of educational activities, the introduction of digital technologies in the educational process can be noted.
Financial component of the hydrogen economy development strategy of Ukraine
Authors: Khalatur Svitlana
Published: November 2024

The relevance of the study is determined by the need to detail the financial justification of the development of the hydrogen economy in Ukraine, taking into account the need to ensure energy independence and diversification of energy resources. With a sufficient number of publications on the innovativeness of hydrogen technologies, global trends in their use and the importance of decarbonization of public production, the issue of financial support for the development of the hydrogen economy remains insufficiently covered.
The purpose of the article is to highlight and characterize the financial component of the strategy for building the hydrogen economy of Ukraine. To achieve the goal, general and special methods of scientific research were used: abstraction, decomposition, comparison, analysis, extrapolation.
According to the results of the study, a derived relationship between the number of scientific studies on the development of hydrogen technologies and the state of the energy market was revealed, which made it possible to put forward a hypothesis about the intensity of research on the prospects for the development of the hydrogen economy in the context of the adequacy of its financing. The existing hydrogen technologies can be applied only in connection with the development of renewable energy, they require increased innovations in production, infrastructure, and consumption of hydrogen, therefore, they require increased financing. The financial component of the Hydrogen Strategy of Ukraine (until 2050), developed by the Ministry of Energy, is highlighted at each stage of its implementation. The foreign experience of strategies for the development of the hydrogen economy is presented and the insufficiency of financial resources to ensure the achievement of the target indicators of the Ukrainian strategy, especially in the conditions of war, is stated. The relationship between the Hydrogen Strategy of Ukraine and the Recovery Plan of Ukraine until 2032 is characterized. The general need for financing the development of the hydrogen economy at the second stage of the implementation of the Hydrogen Strategy was determined in connection with the content of the pilot projects.
Accordingly, there is a need to detail the focus and sources of funding for the hydrogen economy development strategy in Ukraine, potential sources of cash receipts, changes in institutional and regulatory support for the hydrogen strategy.
Formation of an effective mechanism of innovation management at enterprises
Authors: Shovkun-Zablotska Lyudmila
Published: November 2024

The article examines the importance of the formation of an effective mechanism of innovative management in the conditions of the modern global economy and the state of war. Attention is focused on the essence of innovation management, its main tasks and elements, such as strategy, organizational structure, innovation processes, innovation culture, knowledge management and financing. The problems and challenges that arise during the implementation of innovative management in the conditions of war are highlighted separately, in particular, the need to adapt strategies to the changing environment and resource limitations. The prospects for the development of innovative mechanisms in the context of digital technologies and artificial intelligence, which can contribute to rapid adaptation to new conditions, are also considered. The article emphasizes that an effective innovation mechanism is the key to achieving high results and competitiveness of organizations even in difficult conditions.
Pectus excavatum corrected by locally adapted Nuss procedure: A case report
Authors: Saha Heemel , Saha Sanjay Kumar , Saha Leema , Ullah Mohammad Ata , Parvez M. Nayeem
Published: November 2024

Not available.
Translating English Articles from Mongolian: A Case Study of Natsagdorj’s Shuvuun Saaral
Authors: Byambasaikhan Nomindari , Tsedenbazar Enkhbaatar , Amar Mungunchimeg
Published: November 2024

This study investigates the complexities involved in translating English articles into Mongolian, focusing on Natsagdorj D.’s seminal work, Shuvuun Saaral. The absence of articles in Mongolian presents significant challenges for translators, educators, and learners, necessitating sophisticated linguistic strategies to convey intended meanings accurately. By analyzing sentences from the Mongolian novel translated into English by Western Washington University, this study explores the translation of indefinite, definite, and zero articles. The theoretical framework integrates Hawkins' (1978) referential or location theory and Bickerton's (1981) language roots theory. This study provides insights into contextual meaning conveyance, elucidates how English definite articles are translated into Mongolian, and interprets the strategies employed by translators, along with the challenges and opportunities in article translation.
Enhancing Metalinguistic Awareness Through Microlearning: A Comparative Analysis of Catalan Acquisition Between Multilingual French and English Learners
Authors: Gagné Nancy , Joan Casademont Anna
Published: November 2024

Knowing that previously learned languages may influence and support language learning among multilingual learners, equipping educators with diverse tools and resources empowers them to make more informed decisions in facilitating language learning. This holds particular significance in the case of minority languages like Catalan, where resource availability tends to be more restricted. This paper presents the findings of a project aimed at identifying the specific needs of multilingual B1 learners of Catalan. Using a comprehensive five-way classification system, the study compares the written productions of multilingual learners from different linguistic backgrounds (English and French L1 learners of Catalan). Analyses revealed a similar pattern regarding the nature of the errors, with incorrect word selections at the lexical-semantic, syntactic, and orthographic levels being the most frequent. Both groups differ significantly in terms of the distribution of errors; however, they did not differ when the analyses were conducted by error types. In both cases, the most frequent error was the lexical-semantic misselections, with false analogies and incomplete applications of rules explaining the errors. These findings led to the creation of just-in-time microlearning capsules tailored to address these issues. The microlearning capsules were designed to enhance students' metalinguistic awareness. Students' and teachers' perceptions of the tool were also assessed, and both groups predominantly viewed interlinguistic information as beneficial to language learning. This project highlights how microlearning, tailored to frequent errors, can bolster multilingual learners' acquisition and provides promising tools for language teaching.
Baroreflex Control of Heart Rate in Young and Adult Salt Hypertensive Inbred Dahl Rats
Authors: Nedvídek J , Zicha J
Published: November 2024

Baroreflex control of heart rate was studied in inbred salt-sensitive (SS/Jr) and salt-resistant (SR/Jr) Dahl rats that were subjected to chronic dietary sodium chloride loading (for 4 weeks) either in youth or only in adulthood, i.e. from the age of 4 or 12 weeks. Using phenylephrine administration to pentobarbital-anesthetized male rats we have demonstrated the decreased baroreflex sensitivity (lower slope for reflex bradycardia) in young prehypertensive SS/Jr rats fed a low-salt diet as compared to age-matched SR/Jr animals. High salt intake further suppressed baroreflex sensitivity in young SS/Jr but not in SR/Jr rats. Baroreflex sensitivity decreased with age in SR/Jr rats, whereas it increased in SS/Jr rats fed a low-salt diet. Thus at the age of 16 weeks baroreflex sensitivity was much higher in SS/Jr than in SR/Jr animals. High salt intake lowered baroreflex sensitivity even in adult SS/Jr rats without affecting it in adult SR/Jr rats. Nevertheless, baroreflex sensitivity was significantly lower in young SS/Jr rats with a severe salt hypertension than in adult ones with a moderate blood pressure elevation. It is concluded that the alterations of baroreflex sensitivity in young inbred SS/Jr rats (including the response to high salt intake) are similar to those described earlier for outbred salt-sensitive Dahl rats. We have, however, disclosed contrasting age-dependent changes of baroreflex sensitivity in both inbred substrains of Dahl rats.
Changes of Acute-Phase Proteins in Streptozotocin-Induced Diabetic Rats
Authors: Saso L , Tommasino P , Italiano G , Grippa E , Leone MG , Gatto MT , Silvestrini B
Published: November 2024

Quantitative and qualitative changes of serum proteins, apart from glycation, have not been sufficiently studied in streptozotocin-induced diabetic rats (D), the most common experimental model for diabetes. Thus, we decided to analyze the serum of diabetic rats by concanavalin A-blotting in comparison with rats with acute inflammation induced by fermented yeast (Y), in which characteristic alterations of serum proteins have been described. Two months after the streptozotocin treatment, the blood glucose levels were highly elevated (456± 24 vs. 124± 10 mg/dl, p<0.001, n=12), the body weight was significantly lower than normal (279± 10 vs. 392± 6 g, p<0.001, n=12), and serum proteins appeared to be highly glycated (p<0.001) when analyzed by the fructosamine assay, without any significant change in the total serum protein concentration. Analysis by concanavalin A-blotting, revealed a significant decrease of a1-inhibitor-3 (a1-I3, p<0.05) and an increase of the b chain of haptoglobin (b-Hp, p<0.05) in both D and Y rats (n=3) compared with control animals. However, acute inflammation caused a marked rise of two prominent acute phase proteins, a2-macroglobulin and hemopexin, which did not change appreciably in diabetic rats. Further work will be necessary to evaluate the physiopathological significance of these phenomena which could result from changes of both concentration and glycosylation of the aforementioned proteins.
Anti-Müllerian Hormone Can Help With Predicting Ovarian Failure for Premenopausal Women Who Have Undergone Ablative Radioiodine Treatment for Thyroid Cancer
Authors: Havlínová B , Součková I , Kopřivová K , Doležal J
Published: November 2024

Differentiated thyroid carcinoma is the most common endocrinological malignancy with an increasing incidence over the last 30 years, with women being more frequently affected. In indicated cases, total thyroidectomy followed by adjuvant radioiodine administration is performed, despite current trends towards less aggressive treatment. We would like to investigate the possible adverse effects of radioiodine (RAI) on ovarian function using a simple serum biomarker. Anti-Müllerian hormone (AMH) appears to be the best endocrine marker for assessing physiological age-related oocyte loss for healthy women. The aim of our ongoing prospective study is to determine serum AMH to estimate ovarian reserve for premenopausal women treated with RAI. Over the course of one year, 33 serum samples from women with thyroid cancer and 3 serum samples from healthy women were examined. AMH levels were compared before radioiodine treatment and at regular intervals after treatment. Mean of the AMH level was 5.4 ng/ml (n=33) prior to RAI. The average level of AMH decreased to 1.8 ng/ml in 4-6 months after treatment. In 22.2 % of patients AMH dropped to 0 ng/ml from a non-zero value. Thereafter, we observed an increase in AMH, the average value was 2.7 ng/ml in 8-12 months. We demonstrated a significant decrease in AMH shortly after radioiodine treatment and a subsequent trend of increase at one year after treatment. Consequently, predicting the adverse effects of radioiodine by assessing a serum biomarker could help to select an appropriate treatment strategy for young women planning pregnancy.
Politics in translating Utopia in China: a case study of Dai Liuling’s three versions
Authors: Jiang Jiao
Published: November 2024

When examining the dissemination of Thomas More’s Utopia in China, it is imperative to recognize the pivotal role played by a specific translator, Dai Liuling, who facilitated an unprecedented proliferation and readership of the work in the Chinese context. Dai’s translation of Utopia exists three distinct versions: 1956, 1982, and 1997. The 1956 version represents Dai’s initial translation, which was followed by a retranslation in 1982. Due to the popularity of the 1982 version in mainland China, it was subsequently re-editioned in Taiwan in 1997, with modifications to the paratextual section. Through a meticulous analysis of these three versions, with a specific focus on the evolution of paratexts and textual translation, we can observe how Dai’s translations of Utopia were intricately influenced by the political-ideological contexts. Simultaneously, an examination of Dai’s translations can elucidate the trajectory of Utopia’s dissemination in China.
Lyme Disease Experience Survey 2024 - UK Responses Summary Posters
Authors: Cruikshank Anne , Husain Zahra , Lawrence Nicola , Murray Elizabeth
Published: November 2024

Little is formally documented on the lived experience of Lyme disease - the state of diagnosis, treatment & care and the impact on the lives of those infected. Lyme Resource Centre (LRC) conducted an online survey to gather information on the impact of Lyme disease on those directly affected in the United Kingdom & Republic of Ireland. The survey responses from the residents of the United Kingdom are summarised and presented here. Separating the results by country allows comparisons between them regarding awareness, diagnosis, treatment and management.
Homo Civile and Eidos of Civil Society
Authors: Knar Eldar
Published: November 2024

The concept of Homo Civile (Civil Man) was introduced as an authentic subject of civil society. The historical chronology and evolution of the concept of "civil society" are presented. Various aspects, principles, and concepts of civil society are analyzed, including the concept of the rule of law in the context of civil society. The criteria, attributes, structure, functions, characteristics, qualities, and issues of civil society are defined. Cultural identity, competitiveness, openness, and the modernization of consciousness are examined within the framework of civil society. The dominant role of the cultural component in the homeostasis of civil society is noted.
Failure mechanism and control technology of soft-rock roadways subjected to high structural stress
Authors: Li Mingjing , Ye Lijin , Feng Jihao , Fang Yunmai , Wen Haipo , Wu Xiangbin
Published: November 2024

The prevention and control of deformation and instability in high-stress soft rock roadways hold significant value for ensuring normal mine production and the safety of personnel and equipment. This study focuses on the pedestrian descent from the 11th mining area of the Yindonggou Mine, providing a thorough elucidation of the internal mechanisms leading to large deformation and instability in the roadway. It accounts for the influences of surrounding rock lithology, geological structure, and support measures. Consequently, based on the theory of rock instability, corresponding tunnel repair measures and control strategies were proposed and verified through field application. The results indicate that: (1) High strength dispersion and insufficient support resistance of the expansive weak and fractured surrounding rock sections are critical factors inducing significant deformation in the soft rock roadway of Yindonggou Mine. (2) The primary factor contributing to the large deformation disaster in the Yindonggou Mine roadway is the disturbance caused by proximate coal seam mining, which exacerbates the conflict between the high structural stress in the strata and the low strength of the surrounding rock. High-level stress initially leads to deformation in the weakly supported floor, followed by deformation and instability of the surrounding rock, ultimately culminating in the collapse of the entire roadway section. (3) Soft rock support should be designed with varying schemes tailored to the rock type and structural stress of the surrounding rock in the tunnel. For tunnels with carbon mudstone and expansive soft rock as the main roof and floor components, the support plan should primarily focus on enhancing the support stiffness of the tunnel wall. Conversely, for tunnels where sandstone predominates as the roof and floor material, the support plan should aim to restore the three-dimensional stress state of the surrounding rock and fully utilize its self-supporting capacity. (4) Based on the engineering conditions of pedestrian downhill in No.11 mining area of Yindonggou Mine, a differentiated support scheme is proposed. The feasibility and effectiveness of each support scheme are verified by numerical simulation, so as to provide valuable reference and enlightenment for similar projects.
Environmental planning and the evolution of inter-basin water transfers in the United States
Authors: Yi Sooyeon , Kondolf G. Mathias
Published: November 2024

The uneven spatial distribution of water resources and demands across the US have motivated a wide range of inter-basin water transfers. By redistributing water resources, Inter-basin water transfer projects can lead to specific environmental changes such as altered river flows, changes in water quality, and loss of ecologically important habitats, impacts which depend on project scale and management. Early water transfer projects were undertaken prior to legislation Since the primary focus is not on the environmental impacts of these projects, they are often not documented historically. We provided a comprehensive inventory of inter-basin water transfer projects (built, incomplete, proposed) in the US, identified patterns of these projects’ characteristics, analyzed the growing role of environmental planning in these projects, and drew lessons to inform future proposals. We categorized historical US water transfer projects into three periods: 1900–1930, 1930–1970, and 1970–2020, analyzing projects over 40 km long and 50 MCM/year using diverse sources, to assess their development from an environmental planning perspective. Results of this study show that the early projects, mostly gravity-driven and smaller-in-scale, grow in scale and require more pumping stations (energy-intensive) to lift the water over high elevations. California and Colorado are the most active, using these transfers for the first time. Federal agencies have reduced funding for most transfers due to a growing recognition of the environmental impacts, which were not adequately addressed in planning of early projects. Environmental impacts are crucial for the planning and operation of inter-basin water transfer projects. We recommend that assessments of climate change vulnerability should also be considered essential for future project proposals.
Rubella antibody levels in the healthy Chinese population: a meta-analysis
Authors: Zhuo Yaning , Lu Zhaojun , Zhang Xuechao , Zhang Xiaoping , Yang Yingying , Han Jiayin , Du Jian , Xu Yuyang , Liu Yan , Fu Chuanxi
Published: November 2024

Objectives

To gain a comprehensive understanding of rubella seroprevalence in the healthy population in China and to offer data-driven support for the goal of rubella elimination.

Methods

CNKI, Wanfang database, VIP database, CBM, PubMed, web of Science, and Embase databases were searched to collect studies reporting the positive rate of rubella antibody among the Chinese healthy populations between 2001 and 2022. We conducted a meta-analysis using R language, and data were combined using random effects model.

Results

A total of 97 studies were included, encompassing a sample size of 103,018. Meta-analysis showed that the overall prevalence of rubella antibody positivity in the Chinese healthy population was 77.29% (95% CI: 75.26-79.33). The prevalence of rubella antibody varied significantly based on age and vaccination status. Among the age groups studied, the <1-year-old group exhibited the lowest positivity rate for rubella antibody at 47.87% (95% CI: 41.53-54.21),while the ≥50 years old group showed the highest positivity rate at 85.43% (95% CI: 81.01-89.85); individuals with a history of vaccination demonstrated a higher antibody positivity rate compared to those without vaccination history.

Conclusions

The prevalence of rubella antibody in healthy Chinese population is relatively low. In order to establish a solid immunity threshold levels, it requires conducting timely immunization programs on key groups such as middle school students and the women of childbearing age on the basis of ensuring a high level of rubella-containing-vaccines (RCV) coverage, so as to achieve the goal of eliminating rubella.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024607949.
Real-time ocean wave prediction in time domain with autoregression and echo state networks
Authors: Holand Karoline , Kalisch Henrik
Published: November 2024

This study evaluates the potential of applying echo state networks (ESN) and autoregression (AR) for dynamic time series prediction of free surface elevation for use in wave energy converters (WECs). The performance of these models is evaluated on time series data at different water depths and wave conditions, including both measured and simulated data with a focus on real-time prediction of ocean waves at a given location without resolving for the surrounding ocean surface, in other words, short-time single-point forecasting. The work presented includes training the models on historical wave data and testing their ability to predict phase-resolved future surface wave patterns for short-time forecasts. Additionally, this study discusses the feasibility of deploying these models for extended time intervals. It provides valuable insights into the trade-offs between accuracy and practicality in the real-time implementation of predictive models for wave elevation, which are needed in wave energy converters to optimise the control algorithm.
Research on the Propagation Law of Temperature-Induced Reflective Cracks in Semi-Rigid Base Asphalt Pavement
Authors: Chen Feng , Yue Aijun
Published: November 2024

In order to solve the problem of reflection cracks in semi-rigid base asphalt pavement, a study of temperature-type reflection crack expansion is carried out according to the typical climatic characteristics of Guilin, Guangxi Province. According to the theory of fatigue fracture mechanics, the stress intensity factor analysis at the crack tip is carried out, the reflection crack propagation life under single-factor and multi-factor changes is calculated using the Paris fatigue growth formula, and the prediction model of the propagation life of reflected crack under the action of a temperature gradient is established. The results show that the propagation life of temperature-type reflective cracks increases with an increase in the thickness of the middle course and bottom course, and decreases with an increase in the surface course modulus, base course modulus, base course thickness, and temperature decrease. The prediction model includes the factors that have a great influence on the reflection crack extension and provides a theoretical supplement and reference for the design and calculation of asphalt pavement structure in areas with large temperature differences.
Traditional Ecological Knowledge (TEK) of the Arctic Cultural Circle in Three Ethnographic Works from China, Russia, and Canada
Authors: Mu Yang , Ma Di
Published: November 2024

This paper analyzes the Traditional Ecological Knowledge (TEK) within the Arctic Cultural Circle by comparing three influential texts: the Russian travelogue Dersu, the Trapper (1923); the Canadian memoir People of the Deer (1952); and the Chinese novel The Last Quarter of the Moon (2005). By examining these texts, which depict the Indigenous cultures of the Nanai, the Ihalmiut, and the Ewenki, the study identifies shared ecological perspectives. These include an emphasis on the sacredness of nature, as seen in their animistic worship and spiritual connection to the environment; a holistic relationship between humans and nature, characterized by a wise and sustainable use of resources and a minimal sense of ownership; and a sense of reciprocity among all living beings, fostering mutual care and respect within the natural world. The paper further contends that the TEK of the circle offers valuable reference for addressing contemporary environmental and social challenges posed by climate change and biodiversity loss, particularly in the context of modernization and globalization.
Personalized Medicine: Unraveling the Potential of Diamine Oxidase Deficiency
Authors: Blasco-Fontecilla Hilario
Published: November 2024

The Special Issue Diamine Oxidase Deficiency: Prevalence, consequences, and solutions brings together a series of groundbreaking studies that explore the role of four single-nucleotide polymorphisms (SNPs) (rs10156191, rs1049742, rs1049793, and rs2052129) of the Diamine Oxidase (DAO) across various medical conditions, with a special focus on its influence on histamine metabolism [...]
Hepatitis C Infection Confirmation and Fewer Visits Contribute to Improving Treatment Rates in a Predominantly African American Health Center
Authors: Auguste Crisshy , Khamis Rana , Naylor Paul , Mutchnick Milton
Published: November 2024

Background/Objectives: The approval of direct-acting antiviral (DAA) therapy for hepatitis C (HCV) resulted in a highly effective oral treatment for patients. The primary objective of this study was to identify reasons that patients were not treated versus why patients were treated. Identifying potential reasons for the failure to treat can provide a pathway to interventions using evidence-based data. Methods: The electronic medical records in an urban predominately African American (AA) population were searched for all patients with HCV seen at least once in a Gastroenterology or Infectious Disease clinic in 2019. Data collected included demographics, treatment visits, laboratory data, insurance and ZIP codes for median income. Results: Of the 441 patients who were not yet treated at the first 2019 visit, only 43% were treated by July 2020. Insurance and median income were not factors in failure to treat. Patients with an average of four visits were more likely to be treated than those with two or less, suggesting that failure to follow up was a significant factor for patient treatment (42% vs. 8% p < 0.0001). Confirmation of viral infection at first visit was an important factor with respect to treatment (treated 38% vs. not treated 25% p < 0.02). Conclusions: Significant numbers of our patients (57%) failed to be treated after at least one clinic visit. The two critical factors were PCR confirmation prior to the initial visit and the requirement for multiple visits before the initiation of treatment. Since the degree of fibrosis had no impact on treatment, initiating treatment immediately after confirming infection with HCV should improve patient treatment rates and outcomes.
A New Method for Joint Sparse DOA Estimation
Authors: Hou Jinyong , Wang Changlong , Zhao Zixuan , Zhou Feng , Zhou Huaji
Published: November 2024

To tackle the issue of poor accuracy in single-snapshot data processing for Direction of Arrival (DOA) estimation in passive radar systems, this paper introduces a method for judiciously leveraging multi-snapshot data. This approach effectively enhances the accuracy of DOA estimation and spatial angle resolution in passive radar systems. Additionally, in response to the non-convex nature of the mixed norm, we propose a hyperbolic tangent model as a replacement, transforming the problem into a directly solvable convex optimization problem. The rationality of this substitution is thoroughly demonstrated. Lastly, through a comparative analysis with existing discrete grid DOA estimation methods, we illustrate the superiority of the proposed approach, particularly under conditions of medium signal-to-noise ratio, varying numbers of snapshots, and close target angles. This method is less affected by the number of array elements, and is more usable in practices verified in real-world scenarios.
Self-Replicating Alphaviruses: From Pathogens to Therapeutic Agents
Authors: Lundstrom Kenneth
Published: November 2024

Alphaviruses are known for being model viruses for studying cellular functions related to viral infections but also for causing epidemics in different parts of the world. More recently, alphavirus-based expression systems have demonstrated efficacy as vaccines against infectious diseases and as therapeutic applications for different cancers. Point mutations in the non-structural alphaviral replicase genes have generated enhanced transgene expression and created temperature-sensitive expression vectors. The recently engineered trans-amplifying RNA system can provide higher translational efficiency and eliminate interference with cellular translation. The self-replicating feature of alphaviruses has provided the advantage of extremely high transgene expression of vaccine-related antigens and therapeutic anti-tumor and immunostimulatory genes, which has also permitted significantly reduced doses for prophylactic and therapeutic applications, potentially reducing adverse events. Furthermore, alphaviruses have shown favorable flexibility as they can be delivered as recombinant viral particles, RNA replicons, or DNA-replicon-based plasmids. In the context of infectious diseases, robust immune responses against the surface proteins of target agents have been observed along with protection against challenges with lethal doses of infectious agents in rodents and primates. Similarly, the expression of anti-tumor genes and immunostimulatory genes from alphavirus vectors has provided tumor growth inhibition, tumor regression, and cures in animal cancer models. Moreover, protection against tumor challenges has been observed. In clinical settings, patient benefits have been reported. Alphaviruses have also been considered for the treatment of neurological disorders due to their neurotrophic preference.
Optimizing the Smart Pump Drug Library Update Process: An Ongoing Effort at an Academic Medical Center
Authors: Olson Courtney , Bouchard Carin
Published: November 2024

Smart infusion pumps with dose-error reduction software and customizable drug libraries have increased the safety of intravenous infusion delivery; however, maintaining the most updated drug library is a multistep process for most infusion pumps, which requires effort and engagement by the end user to activate the latest drug library. Delays in updating the drug library have been shown to impact patient safety. This article reviews steps taken at an academic medical center to improve the drug library update process. Multidisciplinary efforts resulted in improved drug library activation rates; however, despite workflow optimizations and improvements, achieving complete pump fleet library activation in a timely manner after scheduled updates remains challenging.
Microemulsion of Trichilia catigua A. Juss. (Meliaceae) improves memory recovery and reduces oxidative stress after cerebral ischemia in rats
Authors: Chinen Luana Yukari , Medeiros Daniela Cristina de , Mello João Carlos Palazzo de , Sa-Nakanishi Anacharis Babeto de , Godinho Jacqueline , Bacarin Cristiano Correia , Comar Jurandir Fernando , Mattos Bianca Andretto de , Splendor Maria Clara , Pereira Omar Cléo Neves , Oliveira Rúbia Maria Weffort de , Milani Humberto
Published: November 2024

We reported that a lyophilized ethyl-acetate fraction (EAF-L) of Trichilia catigua (popular ‘Catuaba’) facilitated memory recovery and reduced oxidative stress after cerebral ischemia in rats. However, oral doses as high as 400 mg/kg seem necessary to achieve those effects. Here we used an  EAF microemulsion (EAF-ME) to evaluate whether a dose lower than that used previously can be suitable for memory neuroprotection. Intact rats were trained in the aversive radial maze (LRA) and subjected to transient global cerebral ischemia (TGCI). EAF-ME or EAF-L (100 mg/kg each) was administered at 4 hours of reperfusion and repeated in the next 6 days. Retrograde memory performance was assessed 7-, 14-, and 21-days postischemia. In a second experiment, a single EAF-ME dose was given at 4 h of reperfusion. Oxidative stress of brain tissue was assessed at 24 h of reperfusion. Lastly, after the FAE-ME treatment, the brain was examined for GFAP and Iba-1 immunoreactivity as neuroinflammation markers. The rats' ability to recall the AvRM task learned before ischemia was significantly reduced after ischemia (amnesia). Treatment with EAF-ME (100 mg/kg) mitigated this outcome, whereas the same dose of the EAF-L formulation did not. Furthermore, a single administration of the EAF-ME prevented oxidative stress by restoring SOD and CAT activities and reducing protein carbonylation and lipoperoxidation. Ischemia-induced glial cell immunoreactivity, however, was not precluded by the EAF-ME formulation. The current findings demonstrate that the neuroprotective efficacy of T. catigua can be improved by developing appropriate formulations that may enhance the bioavailability of polyphenolic constituents in the brain.
Potential utilization of paddy straw and coconut coir for the cultivation of Pleurotus eous: effects on nutritional composition and antioxidant capacity
Authors: Sirimanne Meleesha Anuprabha , Liyanage Geethika Savindhi
Published: November 2024

Oyster mushrooms (Pleurotus species), which are valued for their medicinal and nutritional properties, are the predominantly cultivated mushroom variety in Sri Lanka. The most commonly used substrate to cultivate Pleurotus species in Sri Lanka is sawdust. However, due to the availability of many other agricultural wastes in Sri Lanka, the aim of this study was to determine which substrate from paddy straw (PS), coconut coir (CC), and combinations of PS and CC in the ratios of 50 PS:50 CC, 75 PS:25 CC, and 25 PS:75 CC would be the best to grow Pleurotus eous. The weight of each mushroom harvested was measured to determine the highest yield. Lowry and phenol-sulphuric assays were carried out to determine the total protein and total carbohydrate content respectively. DPPH and phophomolybdenum assays were used to analyse the antioxidant activity. The total phenolic content was determined using the Folin-Ciocalteu method. All mushrooms tested positive for qualitative tests of terpenoids, steroids, saponins and polyphenols. 100% PS produced mushrooms with the highest yield (34.72 ± 5.23 g). 50 PS:50 CC produced mushrooms with a significantly high total protein content (5.28 ± 0.24 g/100 g) and total carbohydrate content (31.12 ± 5.64 g/100 g). They also had a high total antioxidant capacity (4.51 ± 0.07 mg AAE/g) and total phenolic content (5.45 ± 0.34 mg GAE/g). Therefore, to cultivate Pleurotus eous, the 50 PS:50 CC combination can be utilized. Based on the mushroom yield, 100% PS can also be recommended for cultivation of Pleurotus eous.
O olhar do paciente quanto à satisfação dos serviços prestados na Atenção Primária à Saúde
Authors: Figueiredo Ranna Gabriela Fernandes de , Marasca Rafaela , Costa Juliana Leles , Silva Júnior Denison Rosário da
Published: November 2024

A saúde pública brasileira passou por diversas fases e evoluiu de acordo com os contextos políticos e econômicos preconizados em cada período histórico. Chegou-se ao atual modelo através das políticas oriundas da Constituição Federal de 1988. Assim, a Atenção Primária à Saúde (APS), dentro do contexto do Sistema Único de Saúde (SUS), é vista como uma das principais estratégias de prevenção de doenças, promoção de saúde e acompanhamento longitudinal das famílias brasileiras. Compreender a percepção dos pacientes em relação à qualidade dos serviços é fundamental para garantir uma assistência adequada e promover a satisfação dos usuários. O presente estudo é uma revisão integrativa que tem a finalidade de elencar o olhar do paciente quanto à satisfação dos serviços prestados na Atenção Primária à Saúde. Para isso, foram revisados 19 artigos publicados entre o período de 2014 a 2024, as publicações foram adquiridas por meio do levantamento sistemático na busca eletrônica, em grandes bases de dados, contando com as plataformas Scientific Electronic Library Online (SciELO), Ministério da Saúde (MS), PubMed, Scientific Health Information from Latin America and the Caribbean countries (LILACS), bem como os portais da Organização Mundial de Saúde (OMS). Dessa forma, a análise dos resultados dessa revisão sugerem uma visão geral positiva, com 77,7% dos pacientes considerando-se satisfeitos ou muito satisfeitos com os serviços recebidos. O levantamento revela uma alta taxa de satisfação geral, com 76,2% dos usuários considerando a qualidade do atendimento como muito boa ou boa e 90,3% avaliando o acolhimento da equipe como amigável ou muito amigável. No entanto, uma parcela considerável dos usuários, 16,6%, expressa insatisfação geral, sendo o principal fator para esse resultado o descontentamento relacionado ao conforto e estrutura das unidades básicas de saúde, com 41,3% dos usuários avaliando esses aspectos como péssimos ou ruins. Sendo assim,pode-se ter um impacto significativo ao identificar os fatores que influenciam na satisfação do paciente, promover mudanças positivas nos serviços de saúde, melhorando a experiência do paciente e consequentemente a adesão ao tratamento.