bluuebunny/crossref_metadata_2025 huggingface dataset:
153 Caregiving burden and resilience: a mixed methods analysis in dyads managing a VAD in the home
Authors: Peeler Anna , Abshire Saylor Martha , Choy Lauren , DeGroot Lyndsay , Pavlovic Noelle , Davidson Patricia , Bidwell Julie T.
Published: April 2022

OBJECTIVES/GOALS: Caregivers of patients with ventricular assist devices (VAD) are invaluable contributors to patient health, but they may experience psychological symptoms or worsening quality of life related to caregiving. We aimed to explore VAD caregiving burden and resilience comparing high and low burden patient-caregiver dyads. METHODS/STUDY POPULATION: Using a convergent mixed-methods design, we conducted semi-structured interviews and collected self-reported surveys from patient-caregiver dyads. Patients (n=10, mean age 55.8 years) were mostly white males implanted as destination therapy. Caregivers (n=10, mean age 52.6) were mostly white females. Most dyads were spousal (n=6). Caregiver burden was measured with the Zarit Burden Interview Scale, using the median score to categorize lower and higher burden dyads (median = 12, IQR = 8). Data were analyzed using deductive and inductive coding for thematic analysis. RESULTS/ANTICIPATED RESULTS: Lower and higher burden dyads described the shared burden experience of 1) hyper-vigilance and uncertainty immediately post-implant and 2) changing relationship roles. Lower burden dyads were more likely to able to take on responsibilities outside of caregiving. Contextual differences among higher burden dyads included higher financial strain, less social support, worse quality of life (both patients and caregivers) and worse heart failure severity compared to lower burden dyads. All dyads were resilient, using coping strategies like cognitive reframing, positivity, and adaptation to new roles. Higher burden dyads were more vulnerable to coping fatigue and were more likely to express that the VAD had irreversibly changed their life. DISCUSSION/SIGNIFICANCE: VAD caregiver-patient dyads differ in their levels of caregiver burden. Burden experiences and resilience mechanisms may inform future interventions to reduce caregiver burden in diverse VAD dyads. Knowledge of the caregiver experience and factors contributing to burden can inform the healthcare team in providing essential caregiver support.
156 Social and Health Determinants Influencing Adherence and Access to Treatment for Hearing Loss in Puerto Rican Adults
Authors: de Snyder Soami Santiago , Lugo-Velez Wanda , Pabon-Cruz Karen , Acosta-Perez Edna , Rivera-Febres Cristina , Miranda Marcos Roche
Published: April 2022

OBJECTIVES/GOALS: The main objectives are to obtain a preliminary profile of the adult Puerto Rican patient with hearing impairment and to identify the factors, variables and barriers that thess patients face accessing intervention and adscribing to it. METHODS/STUDY POPULATION: Adults between the ages of 21 and 64 years old were surveyed using a questionnaire with items guided to obtain information regarding their socio-demographic and health characteristics and the variables associated to treatment access and adherence to the intervention plan. A descriptive approach will be used to create the sample profile and an age stratified analysis will be used to interpret the empirical data. The identified variables associated to treatment access and adherence will be identified and analyzed to study if there is a possible geographic zone and socio-economical association. RESULTS/ANTICIPATED RESULTS: Preliminary results suggest that regardless of the subject’s age and degree of hearing loss their socio-economical strata is a decisive factor in treatment adherence as well as the lack of medical insurance coverage for therapy, hearing prosthesis and assistive technology for the hearing-impaired. Access to service was found to be a barrier associated to the subjecs geographical place of origin. DISCUSSION/SIGNIFICANCE: Research findings suggest that there is an association between the socio-economical status of the Puerto Rican hearing impaired patient, the lack of medical coverage and the level of treatment adherence. Patients from a lower socio-economical status and remote towns exhibited less adherence which points to a health disparity for this population.
162 Attitudes Toward the SARS-CoV-2 Vaccine in BIPOC Populations in Los Angeles County
Authors: Jacinto Corey , Huynh James , Huynh Johnny , Melgoza Esmeralda , Melendrez-Gomez Delia , Ahn Taemin , Nadurata Edward
Published: April 2022

OBJECTIVES/GOALS: Our research has three main aims: 1. Measure attitudes toward a SARS-CoV-2 vaccine among BIPOC. 2. Assess the effectiveness of race-conscious public health messages in changing attitudes toward a SARS-CoV-2 vaccine. 3. Test the efficacy of financial incentives to increase uptake of a SARS-CoV-2 vaccine. METHODS/STUDY POPULATION: We surveyed 784 unvaccinated residents of L.A. County. To recruit participants, we collaborated with Qualtrics. The survey randomized participants to one of three public health messages, as well as one of two financial compensation schemes. Twenty-five participants completed semi-structured interviews via Zoom or telephone. Interviews were audio recorded, translated into English if needed, and transcribed. The inductive, semi-structured interview guide focused on three domains: i) concerns and distrust toward a COVID vaccine, ii) policy interventions and/or government action related to a COVID vaccine, iii) non-pharmacological policy interventions related to the COVID-19 pandemic. Major emergent themes were identified and analyzed using Watkins (2012) team analysis of qualitative data steps. RESULTS/ANTICIPATED RESULTS: Many BIPOC remain vaccine hesitant: 2/3 of the survey respondents stated that they did not intend to or were not sure if they planned to get vaccinated. Follow-up interviews show that fear of vaccine side effects, bodily autonomy in choosing to get vaccinated are major concerns. However, public health measures like masking and physical distancing remain preferred safety methods for BIPOC residents. Misinformation and overcommunication in public health messaging concerning vaccine eligibility may be a major barrier to vaccine uptake among BIPOC. DISCUSSION/SIGNIFICANCE: Real world financial compensation mechanisms need to provide large enough compensation to avoid a crowding out of altruistic vaccination motivations and to effectively incentivize increased vaccine uptake. Additionally, short race-conscious public health messages were ineffective at improving vaccine attitudes.
164 Better Together: Community Engagement During COVID-19
Authors: Kraschnewski Jennifer , Murray Andrea
Published: April 2022

OBJECTIVES/GOALS: The Penn State CTSI has been working diligently to help communities in their fight against COVID-19. As the rapidly evolving COVID-19 situation has unfolded the Penn State CTSI has been able to provide support to our community stakeholders. As our communities have and are faced with unprecedented challenges, our CTSI has been there every step of the way. METHODS/STUDY POPULATION: The Penn State CTSI is unique as it sits in rural Pennsylvania that not only spans a wide catchment area but also many diverse communities. The Penn State CTSI connected with our communities throughout the pandemic to bring timely and culturally appropriate information about the novel COVID-19 pandemic through our own institution and in partnership with community leaders. Stakeholder boards were formed to hear from various communities about hardships and challenges that were and are being faced due to COVID-19. RESULTS/ANTICIPATED RESULTS: The Penn State CTSI provided our communities with information through various different platforms to ensure that needs were being met in dissemination of pertinent information related to COVID-19. No only was information tailored to the specific needs that were discussed during stakeholder boards, the information was provided in different languages and platforms in order to meet cultural and other needs to ensure health equity and literacy were met. DISCUSSION/SIGNIFICANCE: Not only did the Penn State CTSI provide these services to our current community partners new partnerships were formed to create stronger alliances amongst those being serve. Members of the Penn State CTSI were invited to serve on state and local advisory bords and became trusted messengers in our communities.
170 Perceptions of Relevance and Delivery Modes of Research Best Practices Training for Community Health Workers and Promotoras.
Authors: Varma Deepthi Satheesa , Samuels Elias , Sprioff Meghan , Price Melisa , Loera Gustavo , Murphy Luisa , Sergio-Aguilar-Gaxiola  , Cottler Linda B. , Murphy Susan
Published: April 2022

OBJECTIVES/GOALS: Researchers include community health workers and promotoras (CHW/Ps) on research teams to increase community engagement; however, no formal training on research best practices exists for this group. Study objectives were to examine perceived relevance of a new culturally and linguistically appropriate CHW/P training and optimal delivery modes. METHODS/STUDY POPULATION: We conducted six focus groups (FGs), three each in English and Spanish, at three study sites, University of Florida, University of Michigan, and University of California Davis from February to August 2021. The CHWs/Ps were purposively selected to include diverse age, race/ethnicity, educational level, and work experience. Separate FGs were conducted for CHWs/Ps in English and Spanish as appropriate. All FGs were audio recorded, translated to English from Spanish, transcribed and analyzed using RADaR (Rigorous and Accelerated Data Reduction) technique. RESULTS/ANTICIPATED RESULTS: Forty CHWs/Ps (95% women, mean age 45) participated, with the majority (58%) identifying as Hispanic/Latino. Of the sample, most identified as White (50%) or Black (25%). The proposed training was mentioned as relevant and would help them to be confident, comfortable, knowledgeable and effective in the community. Online training, though advantageous due to its flexibility also reportedly had barriers such as internet access, computer availability and technological know-how of CHWs/Ps. A hybrid training approach, online plus peer-led, was recommended due to the importance of personal guidance by an experienced CHW/P’ especially for a newly recruited CHW/P. DISCUSSION/SIGNIFICANCE: Findings indicated that a culturally and linguistically appropriate CHW/P training that is flexible and easily accessible in its mode of delivery is relevant and useful. In-person guidance to a new CHW/P was reported as an important training component. Poster will include the detailed quotes on relevance, usefulness, and mode of delivery of training.
177 Contextual Pathways Linking Racial Discrimination to Rural Black American Mens COVID Vaccine Hesitancy
Authors: Curtis Michael , Kogan Steven M , Whalen Christopher C
Published: April 2022

OBJECTIVES/GOALS: The present study investigated contextual factors linking rural Black American mens experiences of racial discrimination to their COVID vaccine hesitancy. Specifically, we investigated two potential mediators of the link between racial discrimination and COVID vaccine hesitancy: (1) medical mistrust, and (2) COVID conspiratorial beliefs. METHODS/STUDY POPULATION: Hypotheses were tested using structural equation modeling with 7 waves of data from 504 Black American men participating in a longitudinal study of risk behavior and substance use during young adulthood. At baseline, mens mean age was ~20. Data were collected before and during the COVID pandemic. The COVID pandemic began after Wave 4 data had been collected. A series of 3 online surveys, at 3-month intervals, were conducted to examine acute COVID-related stressors and impacts. RESULTS/ANTICIPATED RESULTS: The dual mediation model fit the data as follows: Ï‡2(7) = 19.00, p < .008; Ï‡2/ df = 2.71; RMSEA = 0.06; CFI = 0.95; SRMR= 0.04. Results indicated that racial discrimination was directly associated with increases in COVID conspiratorial beliefs (B = .14, p<.05) and medical mistrust (B = .22, p<.001). COVID conspiratorial beliefs was directly associated with increases in COVID vaccine hesitancy (B = .11, p<.05). Indirect effects were detected whereby racial discrimination was associated with increases COVID vaccine hesitancy indirectly via increases in COVID conspiratorial beliefs (B = 0.016; 95% CI [0.001, 0.048]). DISCUSSION/SIGNIFICANCE: Investigating race-related factors in the context of vaccine hesitancy is a novel area of inquiry that could facilitate the development of targeted interventions for Black Americans to increase their vaccine uptake. Future research is needed to more thoroughly examine the relationship between racial discrimination and conspiratorial beliefs.
178 Promoting Diversity and Inclusion through the Black Voices in Research Storytelling Curriculum: Instructional Design and Pilot Implementation
Authors: Strekalova Yulia A. Levites , Kolb H. Robert , Xirau-Probert Patricia , Pineda Tiffany
Published: April 2022

OBJECTIVES/GOALS: Last year, we reported on storytelling events highlighting the experiences of Black biomedical professionals. The goal of this continuation study was to put Black Voices into action through a companion curriculum, instructional materials, and facilitated meaningful discussions around racial justice. METHODS/STUDY POPULATION: We developed instructional materials and pilot-implemented the curriculum in a 250-student Healthcare Leadership class. Prior to viewing the video, participants were asked to provide a definition of diversity, inclusion, and equity. Afterwards, the students reflected and suggested changes to the definition. Throughout the class, instructors facilitated group discussions about the role of diversity. As a culminating activity, students submitted a written reflection summarizing their understanding of the role of diversity, inclusion, and equity in healthcare. RESULTS/ANTICIPATED RESULTS: Instructional materials included videos, a facilitators guide, a reflection worksheet, and online course modules. The facilitators guide included an overview of best practices in the facilitation of group discussions, common rules groups can establish for open dialogue, and discussion questions specific to the Black Voices videos. In-class and lab discussions brought up several prominent metaphors for diversity and inclusion. For example, students first defined diversity as pieces of the puzzle that somehow fit together, but later surmised that the pieces do not need to fit, or be from the same puzzle. DISCUSSION/SIGNIFICANCE: Our pilot showed that participants experienced the power of storytelling, particularly for amplifying Black voices, gained a vehicle to expand awareness and consciousness of diversity, equity, and inclusion, and identified plans to promote and facilitate stories of race, equity, and diversity.
180 A Translational Approach to Uterine Fibroids in Black Women and Latinas
Authors: Orellana Minerva , Stewart Elizabeth A. , Balls-Berry Joyce E. , Enders Felicity
Published: April 2022

OBJECTIVES/GOALS: Uterine fibroids (UF), non-cancerous myometrial neoplasms, affect 11 million women in the US. In qualitative research, experiences of Black women (BW) and Latinas (HL) with UF are understudied. UF etiology is poorly understood, and most symptoms are focused on decreasing UF symptoms. This study will showcase a translational approach in studying UF. METHODS/STUDY POPULATION: A community-engaged research process will be used throughout the study. We have a partnership with the Fibroid Foundation (FF), a UF advocacy organization. For our first aim, we have held community-engagement (CE) studios to provide insight for best practices in creating and implementing culturally appropriate studies with ethnoracially diverse women regarding topics of UF. Our CE studios set the foundation for the second aim, which will be in-depth interviews assessing the sociocultural impacts among pre-menopausal BW and HL with UF. The women will be recruited through the FFs social media platform. To address lack of treatment options in UF, we will be focusing on JAK 2/3 pathway. We will be performing immunofluorescence on tissue microarrays on over 100 patient samples with extensive clinical and survey data. RESULTS/ANTICIPATED RESULTS: We held two CE studios, one with BW with UF and another with HL without UF. These participants were chosen as patient stakeholders. One theme from the CE studio was that both groups mentioned a cultural impact around menstrual health and UF discussions. The participant stakeholders provided insight to other influences in their journey that will be used to develop the interview guide questions for Aim 2. We expect the individual interviews to show similar experiences as our CE studio experiences. We anticipate more in-depth conversations about the sociocultural and ethnoracial factors impacting UF treatment. For Aim 3, we hypothesize that there will be increased JAK 2/3 expression in UF of patients with higher sympton burden and larger fibroid volume. DISCUSSION/SIGNIFICANCE: Implementing a community-engaged research framework provides a foundation for qualitative and translational gynecologic research in BW and HL. This project will contribute insight to their UF experience. There is a lack of innovative treatments, and we have access to valuable patient tissue and data that can be used for potential molecular targets.
184 Cross-institutional collaborations for health equity research at a CTSA
Authors: Whipple Elizabeth C. , Ramirez Mirian , Dolan Levi , Hunt Joe D.
Published: April 2022

OBJECTIVES/GOALS: We were interested in health equity research for each CTSA-affiliated institution, specifically focusing on cross department and cross-campus co-authorship. We conducted a bibliometric analysis of our CTSA-funded papers relating to diversity and inclusion to identify cross department and cross-campus collaborations. METHODS/STUDY POPULATION: We worked with our CTSAs Racial Justice, Diversity, Equity and Inclusion Task Force to conduct an environmental scan of diversity and inclusion research across our CTSA partner institutions. Using the Scopus database, searches were constructed to identify and retrieve the variety of affiliations for each of the CTSA authors, a health equity/health disparities search hedge, and all of our CTSA grant numbers. We limited the dates from the beginning of our CTSA in 2008-November 2021. We used PubMed to retrieve all MeSH terms for the articles. We used Excel to analyze the data, Python and NCBIs Entrez Programming Utilities to analyze MeSH terms, and VOSviewer to produce the visualizations. RESULTS/ANTICIPATED RESULTS: The results of this search yielded 94 articles overall. We broke these up into subsets (not mutually exclusive) to represent five of the researcher groups across our CTSA. We analyzed the overall dataset for citation count, normalized citation count, CTSA average authors, gender trends, and co-term analysis. We also developed cross department co-authorship maps and cross-institutional/group co-authorship maps. DISCUSSION/SIGNIFICANCE: This poster will demonstrate both the current areas where cross-departmental and cross-institutional collaboration exists among our CTSA authors, as well as identify potential existing areas for collaboration to occur. These findings may determine areas our CTSA can support to improve institutional performance in addressing health equity.
186 Community Research Academy: Lifting Community Voices for Equity in Health Research and Innovation
Authors: Phillips Lula Mae , Tiffany-E Jennifer Sarah , Ashley-Natasha Ashley Natasha , Chayka Agnes
Published: April 2022

OBJECTIVES/GOALS: To engage community partners in full spectrum of translational sciences participants will: 1. Develop community-based research projects. 2. Evaluate pilot awards submitted to the Community Advisory Board for funding. 3. Actively participate in the research cores at the CTSC METHODS/STUDY POPULATION: The Academy workshop curriculum supports an in-depth examination of the translational research process, introduction to the CTSC Community Advisory Board; as well as to community based participatory research; grant evaluation process, and the need for active community involvement in various cores, and clinical trials. Workshops presented by tenured professionals and community leaders with multi-media out of class assignments. Scheduled sessions were 1 hour, and 15 minutes. Exams given post class session with a mean score of 22.8/30 for session 1 and a mean score of 23.80/30 for session 2. RESULTS/ANTICIPATED RESULTS: The Community Research Academy (CRA) has thus far held for two sessions. Of the 45 enrollees, 20 completed the entire program. Of those, ten have joined the CAB board; and three have actively participated in the pilot award review process. One of the CRA graduates will be publishing her photo novella assignment in Health Affairs. One person changed careers,: and several people have taken all the classes for a second time. Many participants originally came from our faith-based connections. Now word of mouth is expanding the program. DISCUSSION/SIGNIFICANCE: Community engagement ensures that the fresh voices of diverse populations are involved in translational science. Their input ultimately leads to creating novel clinical innovations; such community-driven ingenuity which addresses the deeply felt needs of those communities.
190 Enhancing Research Ethics, Equity and Protections for Uninsured Study Participants
Authors: Pascalev Assya , Otado Jane , Adler Priscilla N. , Blackman Marc R. , Vittone Sarah
Published: April 2022

OBJECTIVES/GOALS: To increase diversity in clinical and translational research (CTR), to strengthen protections for uninsured and under-insured study participants from vulnerable groups by addressing their medical, ancillary care and psycho-social needs and to develop a systematic ethically sound approach to addressing such needs in the study protocol and budget. METHODS/STUDY POPULATION: We conducted) ethical analyses of: (1) the regulatory and ethics scholarship concerning protections and duty of care to research participants from vulnerable groups, and 2) arguments concerning the nature and scope of ancillary care obligations of researchers, as well as 3) a review of the applicable local, federal, and international regulations and practices concerning the duty of care to CTR participants and potential participants who are uninsured, under-insured and/or undocumented members of vulnerable groups. RESULTS/ANTICIPATED RESULTS: Uninsured and underinsured study participants pose major ethical challenges for CTR as medical needs arising during a study are usually covered by the participants own insurance. Lack of health insurance increases vulnerability and creates (1) a barrier to research participation for members of socially disenfranchised groups, (2) risk of discriminatory exclusion of such participants from clinical studies, and (3) inter-institutional inconsistencies in meeting their medical needs; thus limiting diversity in CTR. To address the challenges, we propose an inclusive, systematic, ethically sound approach, which deliberately plans for and provides resources within a study protocol to address the medical and psycho-social needs of uninsured participants during and beyond the study. DISCUSSION/SIGNIFICANCE: Including diverse participants in CTR ensures data quality and social justice. PIs and IRBs should adopt an inclusive approach to the medical needs of vulnerable uninsured participants, plan for their medical and ancillary care needs in the protocol and budget, list community resources, provide follow-up support and note assistance in their files.
Older Burial Disturbance: Postfunerary Manipulation of Graves and Corpses in Precontact Northeastern Brazil
Authors: Solari Ana , da Silva Sergio F. S. M , Pessis Anne Marie , Martin Gabriela , Guidon Niede
Published: April 2022

At times funerary practices do not end with the deposition of the corpses in their final resting place, because occasionally these supposedly definitive burials are disturbed later. When we can confirm that people were mainly responsible for these disturbances, even when other natural taphonomic factors are present, then we have a situation of anthropic postfunerary manipulation of bodies and graves. Some precontact sites in northeastern Brazil have mortuary contexts with “anomalies” in the deposition of bodies into their graves. Applying a taphonomy-based approach, we analyze these cases and compare them to other burials with similar characteristics from central-eastern Brazil in our discussion of the “alternative” phenomenon of postburial manipulation. The evidence suggests that the anthropic disturbance of older burials and corpses should be understood not as a random event, but as an integral and meaningful part of the mortuary practices of ancient inhabitants from across different regions of Brazil throughout the Holocene. With this work we highlight not only unusual mortuary patterns of precontact human groups in Brazil and South America but also the importance of a taphonomic approach to understanding the complexity and variability of funerary and postfunerary actions.
The Urban/Rural Divide in Athenian Political Thought
Authors: NATHAN CHARLES
Published: April 2022

Contemporary analyses of Athenian democracy have focused on binaries such as mass/elite, free/slave, and male/female, overlooking the urban/rural divide. In this article, I argue that urban/rural was a central cleavage in the Athenian demos. Ancient thinkers including Thucydides, Aristophanes, Plato, Xenophon, and Aristotle paid close attention to urban/rural differences and their consequences during the fifth century. Plato and Aristotle in particular developed sophisticated institutions and strategies to mitigate urban/rural divisions. Attending to the Athenian urban/rural divide deepens our understanding of the demos and highlights the importance of attachments to place, home, and customary ways of life for democratic stability.
A comparison of grazingv. zero-grazing on early-lactation dairy cow performance
Authors: Holohan C. , Mulligan F. J. , Pierce K. M. , Somers J. , Walsh N. A. , McDonald M. , Lynch M. B.
Published: April 2022

To overcome grass supply shortages on the main grazing block, some pasture-based dairy farmers are using zero-grazing (also known as ‘cut and carry’), whereby cows are periodically housed and fed fresh grass harvested from external land blocks. To determine the effect of zero-grazing on cow performance, two early-lactation experiments were conducted with autumn and spring-calving dairy cows. Cows were assigned to one of two treatments in a randomized complete block design. The two treatments were zero-grazing (ZG) and grazing (G). The ZG group were housed and fed zero-grazed grass, while the G group grazed outdoors at pasture. Both treatments were fed perennial ryegrass (Lolium perenne L.) from the same paddock. In experiment 1, 24 Holstein Friesian cows (n= 12) were studied over a 35-day experimental period in autumn and offered fresh grass, grass silage, ground maize and concentrates. In experiment 2, 30 Holstein Friesian cows (n= 15) were studied over a 42-day experimental period and offered fresh grass and concentrates. Average dry matter intake and milk yield was similar for ZG and G in both experiments. Likewise, ZG did not have an effect on milk composition, body condition or locomotion. Zero-grazing had no effect on total nitrogen excretion or nitrogen utilization efficiency in either experiment, or on rumen pH and ammonia concentration in experiment 1. While zero-grazing may enable farmers to supply fresh grass to early-lactation cows in spring and autumn, results from this study suggest that there are no additional benefits to cow performance in comparison to well-managed grazed grass.
Conciliarity in the Borderlands: the Riga Orthodox Council (Sobor) of 1905 and the Church Reform Movement in Imperial Russia
Authors: PAERT IRINA
Published: April 2022

The article focuses on a little-known expression of Orthodox conciliar practice in the Russian Empire, the Riga diocesan congress of 1905, and analyses the extent to which commitment to church renewal was spread in regions and provinces of the empire. The article draws attention to the self-presentation of this assembly as a true council, an embodiment of sobornost’. The article interprets the bold reforms proposed by the congress as a product of nineteenth-century ecclesiological ideas, the active participation of the native clergy and laity and the borderland position of Baltic Orthodoxy, a minority faith in a Lutheran region.
Transmission dynamics of ectoparasitic gyrodactylids (Platyhelminthes, Monogenea): An integrative review
Authors: Tepox-Vivar Natalia , Stephenson Jessica F. , Guevara-Fiore Palestina
Published: April 2022

Parasite transmission is the ability of pathogens to move between hosts. As a key component of the interaction between hosts and parasites, it has crucial implications for the fitness of both. Here, we review the transmission dynamics ofGyrodactylusspecies, which are monogenean ectoparasites of teleost fishes and a prominent model for studies of parasite transmission. Particularly, we focus on the most studied host–parasite system within this genus: guppies,Poecilia reticulata,andG. turnbulli/G. bullatarudis. Through an integrative literature examination, we identify the main variables affectingGyrodactylusspread between hosts, and the potential factors that enhance their transmission. Previous research indicates that Gyrodactylids spread when their current conditions are unsuitable. Transmission depends on abiotic factors like temperature, and biotic variables such as gyrodactylid biology, host heterogeneity, and their interaction. Variation in the degree of social contact between hosts and sexes might also result in distinct dynamics. Our review highlights a lack of mathematical models that could help predict the dynamics of gyrodactylids, and there is also a bias to study only a few species. Future research may usefully focus on how gyrodactylid reproductive traits and host heterogeneity promote transmission and should incorporate the feedbacks between host behaviour and parasite transmission.
How Does the Provision of Childcare Services Affect Mothers’ Employment Intentions? Empirical Evidence from a Conjoint Experiment
Authors: OEHRLI DOMINIQUE , STADELMANN-STEFFEN ISABELLE , LÜTOLF MERET
Published: April 2022

Numerous studies have demonstrated that the provision of early childhood education and childcare services (ECEC) is associated with higher women’s participation in the labor market. However, many questions about the causal relationship between the supply of childcare and patterns of female employment remain open. In an effort to overcome common endogeneity problems, we conducted a conjoint experiment in Switzerland, which enables us to analyze mothers’ employment intentions in different – and even in some hypothetical – contexts. Our results demonstrate that improving the provision of ECEC services does affect mothers’ intentions to engage in paid labor. Nevertheless, mothers comprise a heterogeneous group. As expected, ECEC services’ effects are limited for mothers with comparatively high levels of employment. In contrast, mothers with low levels of employment are quite reactive to changing policy contexts, especially if external childcare spots for preschoolers become affordable. Notably, elasticity is present not only in the behavior of women with preferences for supplementary, external childcare, but also in that of women with preferences for parental or home-centered childcare. Our study thus highlights childcare policies’ potential to change the patterns of female employment in contexts marked by persistent traditional gender roles and limited childcare provision.
The First Full Shelves: Gazeta Stołeczna and Warsaw's First Supermarket, 1990–1994
Authors: Valtin-Erwin Leah
Published: April 2022

After the end of communism, foreign direct investment in Eastern Europe increased dramatically. In December 1990, the Austrian chain BILLA opened the first foreign-owned supermarket in Poland. I examine foreign-owned supermarkets as key spaces of encounter between West and East in which neoliberal ideas about urban space, everyday life, material consumption and retail were promulgated, contested and routinised. Examining coverage of the Warsaw BILLA shops in Gazeta Stołeczna, the local edition of the widely read and arguably most trusted daily newspaper in Poland, I draw from literature in consumer history as well as economic and urban geography alongside concepts from business and marketing to argue that local actors, and in particular the emerging independent press, helped naturalise neoliberal values about consumption and retail in early post-communism.
BEYOND RANDOM CAUSES: HARMONIC ANALYSIS OF BUSINESS CYCLES AT THE MOSCOW CONJUNCTURE INSTITUTE
Authors: Vianna Franco Marco P. , Ribeiro Leonardo Costa , Albuquerque Eduardo da Motta e
Published: April 2022

This article proposes a historical assessment of harmonic analysis of business cycles and its ability to both decompose and build cycles, as received at the Moscow Conjuncture Institute. It traces how the Fourier transform arrived at the Institute, mediated by Henry L. Moore, in the works and actions of Albert Vainshtein, Nikolai Chetverikov, and Nikolai Kondratiev, ultimately leading to Eugen Slutsky’s well-known 1927 article “The Summation of Random Causes as the Source of Cyclic Processes.” Although the evidence does not warrant the assumption that there was an orchestrated effort at the Institute to push forward a research agenda on harmonic analysis of business cycles, it certainly unfolded as more than the summation of random events and individual incursions. Moreover, the Institute as a whole could have produced much more on this matter if it had escaped Stalinist oppression for at least a few more years.
Persistent Legacies of Communism, or the Ongoing Purification of Public Space in Post-1989 Poland
Authors: Kończal Kornelia
Published: April 2022

This article explores how Poland’s cultural landscape has been cleared of the material legacies of communism between 1989 and 2019. By studying political discourses, legal regulations and social practices aiming to rename streets and remove monuments associated with communism, it argues that the Polish de-communization project has undergone a major transformation: from a popular need expressed in a variety of decentred initiatives to a political programme revolving around one centrally organized idea. The persistence of the material legacies of communism in Poland’s cultural landscape reveals both the mobilizing potential as well as the limits of anti-communism, it demonstrates how difficult it has been to provide for a legally binding and practically effective definition of communism and it exemplifies a broader struggle over the question of who should play which role in shaping Poland’s public realm.
Scattering by PEC half-plane and disk placed on parallel planes
Authors: Kaliberda Mstislav E. , Lytvynenko Leonid M. , Pogarsky Sergey A.
Published: April 2022

The scattering by the perfectly electric conducting (PEC) half-plane and PEC zero thickness disk placed on parallel planes is considered. The fields are represented in the spectral domain, i.e. in the domain of Fourier transform. The operator equations with respect to the Fourier amplitudes of the scattered field are obtained. The kernel functions of these equations contain poles. After regularization procedure, which is connected with the elimination of the poles, operator equations are converted to the system of singular integral equations. The convergence of the solution is based on the corresponding theorems. The scattered field consists of the plane wave, reflected by the infinite part of the half-plane, cylindrical waves, which appear as a result of scattering by the edge of the half-plane, and spherical waves, which appear as a result of scattering by the disk and multiple re-scattering by the disk-half-plane. The total near-field distribution and far-field patterns of cylindrical waves are presented.
Limosilactobacillus fermentum prevents gut-kidney oxidative damage and the rise in blood pressure in male rat offspring exposed to a maternal high-fat diet
Authors: do Nascimento Luciana Caroline Paulino , de Souza Evandro Leite , de Luna Freire Micaelle Oliveira , de Andrade Braga Valdir , de Albuqeurque Thatyane Mariano Rodrigues , Lagranha Cláudia Jacques , de Brito Alves José Luiz
Published: April 2022

Oxidative stress along the gut-kidney axis is a risk factor for developing arterial hypertension in offspring from dams fed a high-fat diet. Considering the antioxidant capacity of probiotic strains, this study evaluated the effects of a daily multistrain formulation with Limosilactobacillus fermentum 139, 263, and 296 on blood pressure (BP), renal function, and oxidative stress and along the gut-kidney axis in male offspring from dams fed a high-fat high-cholesterol (HFHC) diet during pregnancy and lactation. Dams were fed a diet control or HFHC diet during pregnancy and lactation. At 100 days of age, part of the male offspring from dams fed a HFHC diet received Limosilactobacillus fermentum formulation for 4 weeks (HFHC + Lf) daily. After the 4-week intervention, BP (tail-cuff plethysmography) and urinary and biochemical variables were measured. In addition, malondialdehyde levels, enzymatic activities of superoxide dismutase, catalase, glutathione-S-transferase, and nonenzymatic antioxidant defense (thiols content) were measured in the colon and renal cortex. Male offspring from dams fed a HFHC had increased blood pressure, impaired renal function, and oxidative stress along the gut-kidney axis. Administration of Limosilactobacillus fermentum reduced systolic, diastolic, and mean blood pressure levels and alleviated renal function impairment and oxidative stress along the gut-kidney axis in male offspring from dams fed a HFHC diet. Administration of Limosilactobacillus fermentum formulation attenuated programmed hypertension in the HFHC group through oxidative stress modulation along the gut-kidney axis.
Complementary or Competing Frames? The Impact of Economic and Public Health Messages on COVID-19 Attitudes
Authors: Knapp Emma R. , Smith Brianna A. , Motta Matthew P.
Published: April 2022

The American reaction to the COVID-19 pandemic is polarized, with conservatives often less willing to engage in risk-mitigation strategies such as mask-wearing and vaccination. COVID-19 narratives are also polarized, as some conservative elites focus on the economy over public health. In this registered report, we test whether combining economic and public health messages can persuade individuals to increase support for COVID-19 risk mitigation. We present preliminary evidence that the combination of messages is complementary, rather than competing or polarizing. When given a message emphasizing COVID-19’s negative health and economic effects in a pilot study, conservatives increased their support for a broad range of risk-mitigation strategies, while liberals maintained high levels of support. A preregistered larger-n follow-up study, however, failed to replicate this effect. While complementary frames may be a promising way to persuade voters on some issues, they may also struggle to overcome high levels of existing polarization.
Turbulent Mixing and Lee‐Wave Radiation in Drake Passage: Sensitivity to Topography
Authors: Gutierrez‐Villanueva Manuel O. , Chereskin Teresa K. , Sprintall Janet , Goff John A.
Published: April 2022

Radiation and breaking of internal lee waves are thought to play a significant role in the energy and heat budget of the Southern Ocean. Open questions remain, however, regarding the amount of energy converted from the deep flows of the Antarctic Circumpolar Current (ACC) into lee waves and how much of this energy dissipates locally. This study estimated the linear lee‐wave energy radiation using a unique 4‐year time series of stratification and near‐bottom currents from an array of Current and Pressure measuring Inverted Echo Sounders (CPIES) spanning Drake Passage. Lee‐wave energy was calculated from two 2D anisotropic and one 1D isotropic abyssal hill topographies. Lee‐wave energy radiation from all three topographies was largest in the Polar Front Zone associated with strong deep meandering of the ACC fronts. Both baroclinic and barotropic instabilities appeared to modulate the conversion to lee waves in the Polar Front Zone. Fine structure temperature, salinity, and velocity profiles at the CPIES locations were used to estimate turbulent dissipation due to breaking internal waves by employing a finescale parameterization. High dissipation near the bottom was consistent with upward‐propagating, high‐frequency lee waves as found by earlier studies. In contrast to idealized numerical predictions of 50% local dissipation of lee‐wave energy, this study found less than 10% dissipated locally similar to some other studies. Improving the representation of the abyssal hills by accounting for anisotropy did not reduce the discrepancy between radiated lee‐wave energy and local dissipation. Instead, alternative fates must be considered for the excess radiated lee‐wave energy.
Summertime Transport Pathways and Dynamics From Northern India and Tibetan Plateau to the Lower Stratosphere: Insights From Idealized Tracer Experiments
Authors: Wu Yutian , Zheng Cheng
Published: April 2022

We use the idealized tracer experiments and investigate the summertime transport from the surface region of northern India and Tibetan Plateau to the lower stratosphere. It is found that the transport, compared to other surrounding regions, has an overall younger modal age in the northern lower stratosphere away from the tropopause. Analysis of the tracer budget reveals that the tracer is transported to the tropical lower stratosphere rapidly in the first 5 days due to vertical eddy transport and afterward in a month or two advection associated with the Brewer‐Dobson circulation. Meanwhile the tracer is also transported to the northern extratropical lower stratosphere in the first 3 months due to horizontal eddy mixing. The results highlight the uniqueness of the northern India region in the summertime transport to the lower stratosphere and implications for the transport of short‐lived chemical species in the destruction of stratospheric ozone.
Identifying Contributors to PM2.5 Simulation Biases of Chemical Transport Model Using Fully Connected Neural Networks
Authors: Liu Jingqi , Xing Jia
Published: April 2022

Accurate prediction of ambient PM2.5 concentrations using air quality models can provide governments with information for public health alerts. However, due to large uncertainties of input parameters and over‐simplification of the chemical mechanism, the model simulations tend to have a certain deviation from the observations. To provide an insight into the discrepancy and to explain the contributors to the model bias, we propose here a machine learning based method to identify the contributors to PM2.5 simulation biases. A fully connected deep neural network (noted as FCNN) was designed to correct the PM2.5 biases between the simulations from a common air quality model (i.e., Community Multiscale Air Quality, CMAQ) and observations with meteorological and pollutants variables. The FCNN was applied in two polluted regions in China including Beijing‐Tianjin‐Hebei (BTH) and Yangtze River Delta (YRD) in 2015, exhibiting excellent performance in reducing the root mean square error of annual PM2.5 by 46.6% and 37.2%, respectively. The relative contribution of each input feature for the bias correction was also estimated from the FCNN. Results suggest that the temperature and humidity exhibit the greatest contribution to the PM2.5 simulation bias among all meteorological factors, probably due to their high association with the physical and chemical reaction conditions. NO2 and SO2 concentrations and associated biases were also found to be crucial to CMAQ model accuracy, implying the importance of NO2‐ and SO2‐related reaction for PM2.5 formation. The study also revealed a cumulative effect of pollution and an enhancement effect of atmospheric oxidation on the formation of heavy pollution.
Microwave-to-optical conversion with a gallium phosphide photonic crystal cavity
Authors: Hönl Simon , Popoff Youri , Caimi Daniele , Beccari Alberto , Kippenberg Tobias J. , Seidler Paul
Published: April 2022

Electrically actuated optomechanical resonators provide a route to quantum-coherent, bidirectional conversion of microwave and optical photons. Such devices could enable optical interconnection of quantum computers based on qubits operating at microwave frequencies. Here we present a platform for microwave-to-optical conversion comprising a photonic crystal cavity made of single-crystal, piezoelectric gallium phosphide integrated on pre-fabricated niobium circuits on an intrinsic silicon substrate. The devices exploit spatially extended, sideband-resolved mechanical breathing modes at ~3.2 GHz, with vacuum optomechanical coupling rates of up to g0/2π ≈ 300 kHz. The mechanical modes are driven by integrated microwave electrodes via the inverse piezoelectric effect. We estimate that the system could achieve an electromechanical coupling rate to a superconducting transmon qubit of ~200 kHz. Our work represents a decisive step towards integration of piezoelectro-optomechanical interfaces with superconducting quantum processors.
Gut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice
Authors: Li Mengci , Wang Shouli , Li Yitao , Zhao Mingliang , Kuang Junliang , Liang Dandan , Wang Jieyi , Wei Meilin , Rajani Cynthia , Ma Xinran , Tang Yajun , Ren Zhenxing , Chen Tianlu , Zhao Aihua , Hu Cheng , Shen Chengxing , Jia Weiping , Liu Ping , Zheng Xiaojiao , Jia Wei
Published: April 2022

Calorie restriction (CR) and fasting are common approaches to weight reduction, but the maintenance is difficult after resuming food consumption. Meanwhile, the gut microbiome associated with energy harvest alters dramatically in response to nutrient deprivation. Here, we reported that CR and high-fat diet (HFD) both remodeled the gut microbiota with similar microbial composition, Parabacteroides distasonis was most significantly decreased after CR or HFD. CR altered microbiota and reprogramed metabolism, resulting in a distinct serum bile acid profile characterized by depleting the proportion of non-12α-hydroxylated bile acids, ursodeoxycholic acid and lithocholic acid. Downregulation of UCP1 expression in brown adipose tissue and decreased serum GLP-1 were observed in the weight-rebound mice. Moreover, treatment with Parabacteroides distasonis or non-12α-hydroxylated bile acids ameliorated weight regain via increased thermogenesis. Our results highlighted the gut microbiota-bile acid crosstalk in rebound weight gain and Parabacteroides distasonis as a potential probiotic to prevent rapid post-CR weight gain.