bluuebunny/crossref_metadata_2025 huggingface dataset:
Changes in blood pressure and related risk factors among nurses working in a negative pressure isolation ward
Authors: Wang Yaoyao , Tian Junzhang , Qu Hongying , Yu Lingna , Zhang Xiaoqin , Huang Lishan , Zhou Jianqun , Lian Wanmin , Wang Ruoting , Wang Lijun , Li Guowei , Tang Li
Published: July 2022

Objective

To observe changes in blood pressure (ΔBP) and explore potential risk factors for high ΔBP among nurses working in a negative pressure isolation ward (NPIW).

Methods

Data from the single-center prospective observational study were used. Based on a routine practice plan, female nurses working in NPIW were scheduled to work for 4 days/week in different shifts, with each day working continuously for either 5 or 6 h. BP was measured when they entered and left NPIW. Multivariable logistic regression was used to assess potential risk factors in relation to ΔBP ≥ 5 mm Hg.

Results

A total of 84 nurses were included in the analysis. The ΔBP was found to fluctuate on different working days; no significant difference in ΔBP was observed between the schedules of 5 and 6 h/day. The standardized score from the self-rating anxiety scale (SAS) was significantly associated with an increased risk of ΔBP ≥ 5 mm Hg (odds ratio [OR] = 1.12, 95% CI: 1.00–1.24). Working 6 h/day (vs. 5 h/day) in NPIW was non-significantly related to decreased risk of ΔBP (OR = 0.70), while ≥ 2 consecutive working days (vs. 1 working day) was non-significantly associated with increased risk of ΔBP (OR = 1.50).

Conclusion

This study revealed no significant trend for ΔBP by working days or working time. Anxiety was found to be significantly associated with increased ΔBP, while no <2 consecutive working days were non-significantly related to ΔBP. These findings may provide some preliminary evidence for BP control in nurses who are working in NPIW for Coronavirus Disease 2019 (COVID-19).
The comparative analysis of SARIMA, Facebook Prophet, and LSTM for road traffic injury prediction in Northeast China
Authors: Feng Tianyu , Zheng Zhou , Xu Jiaying , Liu Minghui , Li Ming , Jia Huanhuan , Yu Xihe
Published: July 2022

Objective

This cross-sectional research aims to develop reliable predictive short-term prediction models to predict the number of RTIs in Northeast China through comparative studies.

Methodology

Seasonal auto-regressive integrated moving average (SARIMA), Long Short-Term Memory (LSTM), and Facebook Prophet (Prophet) models were used for time series prediction of the number of RTIs inpatients. The three models were trained using data from 2015 to 2019, and their prediction accuracy was compared using data from 2020 as a test set. The parameters of the SARIMA model were determined using the autocorrelation function (ACF) and the partial autocorrelation function (PACF). The LSTM uses linear as the activation function, the mean square error (MSE) as the loss function and the Adam optimizer to construct the model, while the Prophet model is built on the Python platform. The root mean squared error (RMSE), mean absolute error (MAE) and Mean Absolute Percentage Error (MAPE) are used to measure the predictive performance of the model.

Findings

In this research, the LSTM model had the highest prediction accuracy, followed by the Prophet model, and the SARIMA model had the lowest prediction accuracy. The trend in medical expenditure of RTIs inpatients overlapped highly with the number of RTIs inpatients.

Conclusion

By adjusting the activation function and optimizer, the LSTM predicts the number of RTIs inpatients more accurately and robustly than other models. Compared with other models, LSTM models still show excellent prediction performance in the face of data with seasonal and drastic changes. The LSTM can provide a better basis for planning and management in healthcare administration.

Implication

The results of this research show that it is feasible to accurately forecast the demand for healthcare resources with seasonal distribution using a suitable forecasting model. The prediction of specific medical service volumes will be an important basis for medical management to allocate medical and health resources.
A Novel Bayesian General Medical Diagnostic Assistant Achieves Superior Accuracy With Sparse History
Authors: Jones Alicia M. , Jones Daniel R.
Published: July 2022

Online AI symptom checkers and diagnostic assistants (DAs) have tremendous potential to reduce misdiagnosis and cost, while increasing the quality, convenience, and availability of healthcare, but only if they can perform with high accuracy. We introduce a novel Bayesian DA designed to improve diagnostic accuracy by addressing key weaknesses of Bayesian Network implementations for clinical diagnosis. We compare the performance of our prototype DA (MidasMed) to that of physicians and six other publicly accessible DAs (Ada, Babylon, Buoy, Isabel, Symptomate, and WebMD) using a set of 30 publicly available case vignettes, and using only sparse history (no exam findings or tests). Our results demonstrate superior performance of the MidasMed DA, with the correct diagnosis being the top ranked disorder in 93% of cases, and in the top 3 in 96% of cases.
Conceptualization of Participation: A Qualitative Synthesis of Brain Injury Stakeholder Perspectives
Authors: Rajala Caitlin , Waterhouse Camden , Evans Emily , Erler Kimberly S. , Bergin Michael J. , Bannon Sarah M. , Slavin Mary D. , Kazis Lewis E.
Published: July 2022

Background

The return to participation in meaningful life roles for persons with acquired brain injury (pwABI) is a goal shared by pwABI, their families, clinicians, and researchers. Synthesizing how pwABI define participation will help to identify the aspects of participation important to pwABI and can inform a person-centered approach to participation outcome assessment. To-date, the qualitative synthesis approach has been used to explore facilitators and barriers of participation post-stroke, and views about participation among individuals with stroke in the UK.

Objectives

This paper's objectives are to (1) conduct a scoping review of qualitative literature that defines and characterizes participation from the perspective of pwABI of any type, (2) synthesize how pwABI define and categorize participation, and (3) link the themes identified in the qualitative synthesis to the International Classification of Functioning, Disability, and Health (ICF) using standardized linking rules to enhance the comparability of our findings to other types of health information, including standardized outcome measures.

Methods

We completed a scoping review of qualitative literature. Our search included PubMed, APA PsychInfo, CINAHL, and Embase databases and included articles that (1) had qualitative methodology, (2) had a sample ≥50% pwABI, (3) had aims or research questions related to the meaning, definition, perception, or broader experience of participation, and (4) were in English. Qualitative findings were synthesized using Thomas and Harden's methodology and resultant themes were linked to ICF codes.

Results

The search identified 2,670 articles with 2,580 articles excluded during initial screening. The remaining 90 article abstracts were screened, and 6 articles met the full inclusion criteria for the qualitative synthesis. Four analytical themes emerged: (1) Essential Elements of Participation (2) How pwABI Approach Participation, (3) Where pwABI Participate, and (4) Outcomes of Participation. Each overarching theme included multiple descriptive themes.

Conclusion

In this paper, we identified themes that illustrate key components of participation to pwABI. Our results provide insight into the complex perspectives about participation among pwABI and illustrate aspects of participation that should hold elevated importance for clinicians and researchers supporting participation of pwABI.
An Evaluation of the Phenotypic Antibiotic Susceptibility of Potential Lactic Acid Bacteria Starter Cultures Isolated From Cambodian Fermented Foods
Authors: Ly Dalin , Mayrhofer Sigrid , Domig Konrad J.
Published: July 2022

The development of indigenous starter cultures for producing fermented foods that meet the expectations of Cambodians is necessary to preserve the country’s food supply. In this study, the safety of 46 lactic acid bacteria strains based on the phenotypic antibiotic susceptibility to clinically relevant antibiotics was assessed. The antibiotic susceptibility of 39 lactobacilli and seven pediococci isolated from Cambodian fermented foods to 16 antibiotics was studied according to ISO 10932/IDF 233. The results were interpreted based on the minimal inhibition concentrations obtained, using differently defined breakpoints and concentration distributions as well as data from the scientific literature. Applying only breakpoints, the results demonstrated two Lactiplantibacillus pentosus, three Companilactobacillus futsaii, three Levilactobacillus namurensis and seven Pediococcus pentosaceus strains with acquired resistance. However, considering further information, one Companilactobacillus futsaii, one Limosilactobacillus fermentum and respectively three Lactiplantibacillus pentosus and Levilactobacillus namurensis strains would possess an acquired resistance. The genetic background for the absence of transmissible antibiotic resistances in lactic acid bacteria strains intended for food application must be confirmed by molecular methods for potential starter cultures.
Sustaining capacity building and evidence-based NCD intervention implementation: Perspectives from the GRIT consortium
Authors: Rakhra Ashlin , Mishra Shivani , Aifah Angela , Colvin Calvin , Gyamfi Joyce , Ogedegbe Gbenga , Iwelunmor Juliet
Published: July 2022

Background

Implementation science has been primarily focused on adoption of evidence-based interventions, and less so on sustainability, creating a gap in the field. The Global Research on Implementation and Translation Science (GRIT) Consortium is funded by the National Heart Lung and Blood Institute (NHBLI) to support the planning, implementation, and sustainability of Late-Stage Phase 4 Translational Research (T4TR) and capacity building for NCD prevention and control in eight low-and middle-income countries (LMICs). This paper highlights perspectives, including barriers, facilitators, opportunities, and motivators for sustaining capacity building and evidence-based hypertension interventions within LMICs.

Methods

Guided by the Capacity, Opportunity, Motivation, Behavior (COM-B) Model, this study surveyed GRIT consortium members on the barriers, facilitators, key motivators, and opportunities for sustaining capacity building and evidence-based hypertension interventions in LMICs. Thematic analysis was used to identify themes and patterns across responses.

Results

Twenty-five consortium members across all eight sites and from various research levels responded to the survey. Overarching themes identifying facilitators, key motivators and opportunities for sustainability included: (1) access to structured and continuous training and mentorship; (2) project integration with existing systems (i.e., political systems and health systems); (3) adaption to the local context of studies (i.e., accounting for policies, resources, and utilizing stakeholder engagement); and (4) development of interventions with decision makers and implementers. Barriers to sustainability included local policies and lack of infrastructure, unreliable access to hypertension medications, and lack of sufficient staff, time, and funding.

Conclusion

Sustainability is an important implementation outcome to address in public health interventions, particularly as it pertains to the success of these initiatives. This study provides perspectives on the sustainability of NCD interventions with a focus on mitigating their NCD burden in LMICs. Addressing multilevel factors that influence the sustainability of capacity building and interventions will have notable implications for other global NCD efforts going forward. Current and future studies, as well as consortium networks, should account for sustainability barriers outlined as it will strengthen program implementation, and long-term outcomes.
Development and therapeutic manipulation of the head and neck cancer tumor environment to improve clinical outcomes
Authors: Duhen Thomas , Gough Michael J. , Leidner Rom S. , Stanton Sasha E.
Published: July 2022

The clinical response to cancer therapies involves the complex interplay between the systemic, tumoral, and stromal immune response as well as the direct impact of treatments on cancer cells. Each individual's immunological and cancer histories are different, and their carcinogen exposures may differ. This means that even though two patients with oral tumors may carry an identical mutation in TP53, they are likely to have different pre-existing immune responses to their tumors. These differences may arise due to their distinct accessory mutations, genetic backgrounds, and may relate to clinical factors including previous chemotherapy exposure and concurrent medical comorbidities. In isolation, their cancer cells may respond similarly to cancer therapy, but due to their baseline variability in pre-existing immune responses, patients can have different responses to identical therapies. In this review we discuss how the immune environment of tumors develops, the critical immune cell populations in advanced cancers, and how immune interventions can manipulate the immune environment of patients with pre-malignancies or advanced cancers to improve therapeutic outcomes.
Street food environmental sustainability in a urbanizing global south: A social practice perspective
Authors: Vignola Raffaele , Oosterveer Peter
Published: July 2022

Selling and buying street food is an every-day practice for millions of urban poor living in cities across Africa, Asia, and Latin America. These practices are embedded in social routines (e.g., for producing food to consuming it and disposing waste) that are dependent on and influence the environmental performance of urban food systems as agents make use of resources (e.g., soil, water, energy, ingredients, etc.). A social science theory being increasingly applied to food systems and sustainability transformations, social practice theory focuses attention on the cultural, institutional, and physical embeddedness of social routines that characterize street food systems. It allows identifying barriers and lock-ins as well as opportunities to de-routinize unsustainable practices and help visualize the linkages and opportunities to nudge the routinization of sustainable practices. Through three examples of social practices in street food systems of the global south, we illustrate those linkages and propose a research agenda to step up the use of these perspective in promoting the contribution of urban street food system to sustainability.
Efficacy and safety of unilateral biportal endoscopy versus other spine surgery: A systematic review and meta-analysis
Authors: Zheng Bin , Xu Shuai , Guo Chen , Jin Linyu , Liu Chenjun , Liu Haiying
Published: July 2022

Background

This study aimed to evaluate the efficacy and safety of unilateral biportal endoscopy (UBE) versus other forms of spine surgery.

Methods

Electronic databases were systematically searched up to February 2022. The authors used Review Manager 5.3 to manage the data and perform the review.

Results

After the preliminary selection of 239 studies from electronic databases, the full inclusion criteria were applied; 16 studies were found to be eligible for inclusion. These 16 studies enrolled 1,488 patients: 653 patients in the UBE group, 570 in the microendoscopic discectomy group, 153 in the percutaneous endoscopic lumbar discectomy group, and 70 in the posterior lumbar interbody fusion group. UBE was superior to microendoscopic discectomy regarding 1-day Visual Analog Scale(VAS) back pain scores (P < 0.00001). No difference was found between UBE and microendoscopic discectomy regarding 1-day Visual Analog Scale leg pain scores (P = 0.25), long-term VAS back pain scores (P = 0.06), long-term VAS leg pain scores (P = 0.05), Oswestry Disability Index scores (P = 0.09) or complications (P = 0.19). Pooled analysis indicated that UBE was similar to percutaneous endoscopic lumbar discectomy regarding 1-day VAS back pain scores (P = 0.71), 1-day VAS leg pain scores (P = 0.37), long-term VAS back pain scores (P = 0.75), long-term VAS leg pain scores (P = 0.41), Oswestry Disability Index scores (P = 0.07) and complications (P = 0.88). One study reported no difference between UBE and posterior lumbar interbody fusion regarding long-term VAS back pain, long-term VAS leg pain, or Oswestry Disability Index scores.

Conclusions

UBE is superior to microendoscopic discectomy to relieve back pain 1 day postoperatively. However, these two procedures are similar regarding 1-day leg pain relief, long-term effects, and safety. UBE and percutaneous endoscopic lumbar discectomy are similar regarding 1-day pain relief, long-term effects and safety. More evidence is needed to evaluate the efficacy and safety of UBE versus posterior lumbar interbody fusion.
Brief Research Report: Expression of PD-1 and CTLA-4 in T Lymphocytes and Their Relationship With the Periparturient Period and the Endometrial Cytology of Dairy Cows During the Postpartum Period
Authors: Souza Carolina Menezes Suassuna de , Lima Ewerton de Souza , Ordonho Raphael Ferreira , Oliveira Bianca Rafaella Rodrigues dos Santos , Rodrigues Rebeca Cordeiro , Moura Marquiliano Farias de , Lima Daniel Magalhães , Blagitz Maiara Garcia , Ramos Sanchez Eduardo Milton , Medeiros Isac Almeida de , Souza Fernando Nogueira , Fernandes Artur Cezar de Carvalho
Published: July 2022

The present study sought to evaluate the expression of PD-1 and CTLA-4 in blood T lymphocytes during the periparturient period and their relationship with uterine health in dairy cows, as determined by endometrial cytology and serum concentrations of β-hydroxybutyrate (BHB) and non-esterified fatty acids (NEFAs), which are indicators of a negative energy balance. The second objective of this study was to investigate whether the expression of PD-1 and CTLA-4 in T lymphocytes is associated with the serum acute phase-protein haptoglobin concentration during the periparturient period. To address these objectives, 26 clinically healthy dairy cows were used. Peripheral blood was collected 14 days prepartum (T-14), at calving (T0), and 30 days postpartum (T30) to measure the expression of PD-1 and CTLA-4 in blood T lymphocytes by flow cytometry. In addition, we collected blood at T0, 10 days after parturition (T10), and T30 to obtain serum and determine the serum concentrations of NEFA, BHB, and Hp. Endometrial cytology was performed at T10, 20 days after parturition (T20), and T30. In the present study, we observed higher expression of CTLA-4 and PD-1 in T lymphocytes at parturition and in the prepartum period, which could indicate a relationship between these immune checkpoints and immunological tolerance during gestation in dairy cattle. In addition, a negative association between the expression of these immune checkpoints prepartum or at parturition and endometrial cytology at T20 and T30 was observed, indicating the negative implications of these immune response regulators in susceptibility to infections. This finding was further corroborated by the relationship between the serum concentration of haptoglobin and the expression of CTLA-4 and PD-1 by T lymphocytes. However, we did not observe a relationship between the indicators of negative energy balance, evaluated by the serum concentrations of BHB and NEFA, and the expression of the immune checkpoint markers studied. Thus, our findings represent an initial step that paves the way for the development of new therapeutic alternatives directed by the host with the objective of increasing the resistance of dairy cattle to infections in this critical period of life.
Aged Population and Immunocompromised Patients: Impact on SARS-CoV-2 Variants and Treatment Outcomes
Authors: Chavda Vivek , Chhabria Mahesh , Apostolopoulos Vasso
Published: July 2022

Patients with an immunocompromised state are at risk of developing a long-term infection from the coronavirus 2 that causes severe acute respiratory syndrome (SARS-CoV-2) [...]
Biomimetic Mineralization in External Layer of Decalcified Fish Scale
Authors: Zhou Yanni , Chai Yadong , Mikami Kurisu , Tagaya Motohiro
Published: July 2022

The mineralization process of the osseous layer, which is highly calcified in vivo, was successfully imitated by the immersion process of the decalcified fish scales in simplified simulated body fluid (SSBF). An alkali treatment was used to modify the native collagen in the decalcified Tilapia fish scale. After the alkali treatment, the mineralization was facilitated in SSBF. The XRD patterns and SEM-EDS observation results demonstrated that the externally-mineralized layers by the immersion process were highly similar to the osseous layer containing lower-crystalline hydroxyapatite, suggesting that the simple biomimetic precipitation process was developed.
The Multi-Omics Landscape and Clinical Relevance of the Immunological Signature of Phagocytosis Regulators: Implications for Risk Classification and Frontline Therapies in Skin Cutaneous Melanoma
Authors: Xing Jiahua , Guo Lingli , Jia Ziqi , Li Yan , Han Yan
Published: July 2022

Tumor-associated macrophages (TAMs) have gained considerable attention as therapeutic targets. Monoclonal antibody treatments directed against tumor antigens contribute significantly to cancer cell clearance by activating macrophages to phagocytose tumor cells. Due to its complicated genetic and molecular pathways, skin cutaneous melanoma (SKCM) has not yet attained the expected clinical efficacy and prognosis when compared to other skin cancers. Therefore, we chose TAMs as an entrance point. This study aimed to thoroughly assess the dysregulation and regulatory role of phagocytosis regulators in SKCM, as well as to understand their regulatory patterns in SKCM. This study subtyped prognosis-related phagocytosis regulators to investigate prognostic differences between subtypes. Then, we screened prognostic factors and constructed phagocytosis-related scoring models for survival prediction using differentially expressed genes (DEGs) between subtypes. Additionally, we investigated alternative treatment options using chemotherapeutic drug response data and clinical cohort treatment data. We first characterized and generalized phagocytosis regulators in SKCM and extensively examined the tumor immune cell infiltration. We created two phagocytosis regulator-related system (PRRS) phenotypes and derived PRRS scores using a principal component analysis (PCA) technique. We discovered that subtypes with low PRRS scores had a poor prognosis and decreased immune checkpoint-associated gene expression levels. We observed significant therapeutic and clinical improvements in patients with higher PRRS scores. Our findings imply that the PRRS scoring system can be employed as an independent and robust prognostic biomarker, serving as a critical reference point for developing novel immunotherapeutic methods.
Radionuclide Delivery Strategies in Tumor Treatment: A Systematic Review
Authors: Poletto Giulia , Cecchin Diego , Bartoletti Paola , Venturini Francesca , Realdon Nicola , Evangelista Laura
Published: July 2022

The aim of this review was to assess recent progress in targeted radionuclide tumor therapy, focusing on the best delivery strategies. A literature search was conducted in PubMed, Web of Science, and Scopus using the terms “radionuclides”, “liposomes”, “avidin–biotin interaction”, “theranostic”, and “molecular docking”. The 10 year filter was applied, except for the avidin–biotin interaction. Data were retrieved from both preclinical and clinical settings. Three targeting strategies were considered: pretargeting, liposomes, and ligands. Pretargeting can be achieved by exploiting the avidin–biotin interaction. This strategy seems very promising, although it has been investigated mainly in resectable tumors. Radiolabeled liposomes have attracted new interest as probes to identify the most suitable patients for treatment with liposomal formulations of common chemotherapeutics. The use of ligands for the delivery of radiotherapeutics to a specific target is still the most appealing strategy for treating tumors. The most appropriate ligand can be identified by virtually simulating its interaction with the receptor. All strategies showed great potential for use in targeted radionuclide therapy, but they also have numerous drawbacks. The most promising option is probably the one based on the use of new ligands.
COVID-19 Survivor Patients Carrying the Rs35705950 Risk Allele in MUC5B Have Higher Plasma Levels of Mucin 5B
Authors: García-Carmona Salvador , Falfán-Valencia Ramcés , Verónica-Aguilar Abigail , Buendía-Roldán Ivette , Chávez-Galán Leslie , Hernández-Zenteno Rafael de Jesús , Martínez-Morales Alfonso , Fricke-Galindo Ingrid , Alanis-Ponce Jesús , Valencia-Pérez Rea Daniela , Gutiérrez-Pérez Ilse Adriana , Zaragoza-García Oscar , Nava-Quiroz Karol J. , Camarena Angel , Mejía Mayra , Guzmán-Guzmán Iris Paola , Pérez-Rubio Gloria
Published: July 2022

Background: Genetic susceptibility to infectious diseases is partly due to the variation in the human genome, and COVID-19 is not the exception. This study aimed to identify whether risk alleles of known genes linked with emphysema (SERPINA1) and pulmonary fibrosis (MUC5B) are associated with severe COVID-19, and whether plasma mucin 5B differs according to patients’ outcomes. Materials and methods: We included 1258 Mexican subjects diagnosed with COVID-19. We genotyped rs2892474 and rs17580 of the SERPINA1 gene and rs35705950 of MUC5B. Based on the rs35705950 genotypes, mucin 5B plasma protein levels were quantified. Results: Homozygous for the risk alleles of the three polymorphisms were found in less than 5% of the study population, but no statistically significant difference in the genotype or allele association analysis. At the protein level, non-survivors carrying one or two copies of the risk allele rs35705950 in MUC5B (GT + TT) had lower levels of mucin 5B compared to the survivors (0.0 vs. 0.17 ng/mL, p = 0.0013). Conclusion: The polymorphisms rs28929474 and rs17580 of SERPINA1 and rs35705950 of MUC5B are not associated with the risk of severe COVID-19 in the Mexican population. COVID-19 survivor patients bearing one or two copies of the rs35705950 risk allele have higher plasma levels of mucin 5B.
Daphne odora Exerts Depigmenting Effects via Inhibiting CREB/MITF and Activating AKT/ERK-Signaling Pathways
Authors: Eom Young Sic , Jeong Dongho , Ryu A-Reum , Song Keon-Hyoung , Im Dai Sig , Lee Mi-Young
Published: July 2022

Daphne odora, a blooming shrub, has been traditionally used for various medicinal purposes. However, information on its anti-melanogenic activity and dermal application is limited. In this study, the Daphne odora extract (DOE), with constituents including daphnetin, was used to investigate depigmenting activity and the underlying mechanism of Daphne odora. DOE inhibited in vitro and cellular tyrosinase activity in a dose-dependent manner, and reduced the α-MSH-induced melanin biosynthesis to a control level. The protein expressions of melanin synthesis-related enzymes were also significantly reduced by DOE. Moreover, DOE decreased the phosphorylation of cAMP-response element binding proteins (CREBs) induced by α-MSH in B16F10 cells, while it activated phosphorylated extra-cellular signal-regulated kinases (ERKs) and protein kinase B (AKT) expression. These results suggest that DOE might inhibit the melanogenesis signaling pathways by activating ERK- and AKT-signaling pathways to regulate the expression of CREB and MITF and its downstream pathways. Therefore, DOE could potentially be developed as a depigmenting agent.
An Exceptional Response to Dostarlimab in Mismatch Repair Deficient, Microsatellite Instability-High and Platinum Refractory Endometrial Cancer
Authors: Bartoletti Michele , Giorda Giorgio , Viel Alessandra , Fornasarig Mara , Zdjelar Adrian , Segatto Enrica , Sorio Roberto , Corsetti Serena , Scalone Simona , Nicoloso Milena Sabrina , Pivetta Tania , Lucia Emilio , Clemente Nicolò , Palazzari Elisa , Canzonieri Vincenzo , Puglisi Fabio
Published: July 2022

Until recently, effective therapies for advanced endometrial cancer progressing to a platinum-based combination were lacking. In this setting, immunotherapy with anti PD-1/PDL-1 monoclonal antibodies is rising as a new paradigm in particular for patients with microsatellites instability/mismatch repair deficiency. In this case report, we describe an exceptional and rapid response to dostarlimab in a platinum refractory endometrial cancer patient with high disease burden harboring a mismatch repair deficiency.
LiDAR Based Detect and Avoid System for UAV Navigation in UAM Corridors
Authors: Aldao Enrique , González-de Santos Luis , González-Jorge Higinio
Published: July 2022

In this work, a Detect and Avoid system is presented for the autonomous navigation of Unmanned Aerial Vehicles (UAVs) in Urban Air Mobility (UAM) applications. The current implementation is designed for the operation of multirotor UAVs in UAM corridors. During the operations, unauthorized flying objects may penetrate the corridor airspace posing a risk to the aircraft. In this article, the feasibility of using a solid-state LiDAR (Light Detecting and Ranging) sensor for detecting and positioning these objects was evaluated. For that purpose, a commercial model was simulated using the specifications of the manufacturer along with empirical measurements to determine the scanning pattern of the device. With the point clouds generated by the sensor, the system detects the presence of intruders and estimates their motion to finally compute avoidance trajectories using a Second Order Cone Program (SOCP) in real time. The method was tested in different scenarios, offering robust results. Execution times were of the order of 50 milliseconds, allowing the implementation in real time on modern onboard computers.
A Computational Quantum-Based Perspective on the Molecular Origins of Life’s Building Blocks
Authors: Amante Gabriele , Sponer Judit E. , Sponer Jiri , Saija Franz , Cassone Giuseppe
Published: July 2022

The search for the chemical origins of life represents a long-standing and continuously debated enigma. Despite its exceptional complexity, in the last decades the field has experienced a revival, also owing to the exponential growth of the computing power allowing for efficiently simulating the behavior of matter—including its quantum nature—under disparate conditions found, e.g., on the primordial Earth and on Earth-like planetary systems (i.e., exoplanets). In this minireview, we focus on some advanced computational methods capable of efficiently solving the Schrödinger equation at different levels of approximation (i.e., density functional theory)—such as ab initio molecular dynamics—and which are capable to realistically simulate the behavior of matter under the action of energy sources available in prebiotic contexts. In addition, recently developed metadynamics methods coupled with first-principles simulations are here reviewed and exploited to answer to old enigmas and to propose novel scenarios in the exponentially growing research field embedding the study of the chemical origins of life.
Improvement of Delegated Proof of Stake Consensus Mechanism Based on Vague Set and Node Impact Factor
Authors: Chen Runyu , Wang Lunwen , Zhu Rangang
Published: July 2022

The Delegated Proof of Stake (DPoS) consensus mechanism uses the power of stakeholders to not only vote in a fair and democratic way to solve a consensus problem, but also reduce resource waste to a certain extent. However, the fixed number of member nodes and single voting type will affect the security of the whole system. In order to reduce the negative impact of the above problems, a new consensus algorithm based on vague set and node impact factors is proposed. We first use fuzzy values to calculate the ratings of all nodes and initially determine the number of agent nodes according to the preset threshold value. Then, we judge whether a secondary screening is needed. If needed, calculating the nodes’ impact factor based on their neighboring nodes, and combining their impact factors with adjacency votes to further distinguish the nodes with the same fuzzy value. In addition, we analyze the dynamic changes in the composition and scale of the agent node set and give its ideal size through testing. Finally, we compare the proposed algorithm with DPoS algorithm and existing fuzzy set-based algorithms in different scales and network structures. Results show that no matter in what kind of network structures, the effectiveness of the proposed algorithm is improved. Among which, the most noticeable improvement is seen in complex network structures.
Nonlinear Dynamics and Entropy of Complex Systems: Advances and Perspectives
Authors: Petrzela Jiri
Published: July 2022

Biological, engineering, economic, social, medical, environmental, and other systems exhibit time evolution [...]
A New Perspective on Cooking Stove Loss Coefficient Assessment by Means of the Second Law Analysis
Authors: Augustin Lomena Mulenda , Vertomene Sumuna Temo , Bernard Ndaye Nkanka , Sadiki Amsini , Haddy Mbuyi Katshiatshia
Published: July 2022

The chimney effect taking place in biomass cooking stoves results from a conversion process between thermal and mechanical energy. The efficiency of this conversion is assessed with the stove loss coefficient. The derivation of this quantity in cooking stove modelling is still uncertain. Following fluid mechanics, this loss coefficient refers to an overall pressure drop through stove geometry by performing an energy balance according to the first law of thermodynamics. From this approach, heat-transfer processes are quite ignored yet they are important sources of irreversibilities. The present work takes a fresh look at stove loss coefficient assessment relying on the second law of thermodynamics. The purpose in this paper is to identify the influence of operating firepower level on flow dynamics in biomass natural convection-driven cooking stoves. To achieve that, a simplified analytical model of the entropy-generation rate in the flow field is developed. To validate the model, experiments are conducted first on a woodburning stove without cooking pot to better isolate physical processes governing the intrinsic behaviour of the stove. Then, for the practical case of a stove operating with a cooking pot in place, data from published literature have served for validation. In particular, mass-flow rate and flue gas temperature at different firepower levels have been monitored. It turns out that losses due to viscous dissipations are negligible compared to the global process dissipation. Exergy analysis reveals that the loss coefficient should rather be regarded from now as the availability to generate flow work primarily associated with the heat-transfer Carnot factor. In addition, the energy flux applied as flow work has to be considered as pure exergy that is lost through consecutive energy-transfer components comprising the convective heat transfer to the cooking pot. Finally, this paper reports a satisfactory agreement that emerged between the exergy Carnot factor and the experimental loss coefficient at different fuel-burning rates.
Energy Cost of Dynamical Stabilization: Stored versus Dissipated Energy
Authors: Allahverdyan Armen E. , Khalafyan Edvard A.
Published: July 2022

Dynamical stabilization processes (homeostasis) are ubiquitous in nature, but the needed energetic resources for their existence have not been studied systematically. Here, we undertake such a study using the famous model of Kapitza’s pendulum, which has attracted attention in the context of classical and quantum control. This model is generalized and rendered autonomous, and we show that friction and stored energy stabilize the upper (normally unstable) state of the pendulum. The upper state can be rendered asymptotically stable, yet it does not cost any constant dissipation of energy, and only a transient energy dissipation is needed. Asymptotic stability under a single perturbation does not imply stability with respect to multiple perturbations. For a range of pendulum–controller interactions, there is also a regime where constant energy dissipation is needed for stabilization. Several mechanisms are studied for the decay of dynamically stabilized states.
Memory and Entropy
Authors: Rovelli Carlo
Published: July 2022

I study the physical nature of traces. Surprisingly, (i) systems separation with (ii) temperature differences and (iii) long thermalization times are sufficient conditions to produce macroscopic traces. Traces of the past are ubiquitous because these conditions are largely satisfied in our universe. I quantify these thermodynamical conditions for memory and derive an expression for the maximum amount of information stored in such memories as a function of the relevant thermodynamical parameters. This mechanism transforms low entropy into available information. I suggest that all macroscopic information has this origin in past low entropy.
Sedimentary Architecture Analysis of Deltaic Sand Bodies Using Sequence Stratigraphy and Seismic Sedimentology: A Case Study of Jurassic Deposits in Zhetybay Oilfield, Mangeshrak Basin, Kazakhstan
Authors: Ni Jun , Zhao Dingding , Liao Xixuan , Li Xuanran , Fu Libing , Chen Ruxian , Xia Zhentong , Liu Yuming
Published: July 2022

Three-dimensional (3D) seismic data and well log data were used to investigate the sandstone architecture of the Middle Jurassic deltaic reservoirs of the Zhetybay Oilfield, Mangeshrak Basin, Kazakhstan. The base-level cycles of different scales were identified and divided using well log and 3D seismic data. Five types of sedimentary boundaries were identified in the mouth bar sandstones. The boundaries divide single mouth bars. Vertically, the spatial distribution of sand bodies can be divided into superposed, spliced, and isolation modes. Laterally, contact modes can be divided into superposition, lateral, and isolation modes. We found that the base-level cycle controls the evolution of the delta front sand body architecture. In the early decline or late rise of the base-level cycle, the superimposed or spliced modes dominate the sand body. By contrast, the lateral or isolation modes dominate the sand body in the late decline or early rise of the base-level cycle. This paper proposes an architecture model of the delta front sand bodies controlled by the base-level cycle. The spatial distribution and morphological variation of deltaic sand bodies could be linked to the base-level cycles.
Distribution Strategy Optimization of Standalone Hybrid WT/PV System Based on Different Solar and Wind Resources for Rural Applications
Authors: Yang Yan , Wei Qingyu , Liu Shanke , Zhao Liang
Published: July 2022

The characteristics of solar and wind energy determine that the optimization of a standalone hybrid wind turbine (WT)/photovoltaic panel (PV) system depends on the natural resources of the installation location. In order to ensure system reliability and improve the resource utilization, a method for determining the installed capacity ratio of a hybrid renewable energy system is required. This study proposes a calculation method to optimize the installed capacity ratio, considering the system reliability to meet the needs of the hybrid system to adapt to different natural resources. In this paper, a standalone hybrid WT/PV system to provide electricity for rural areas is designed. Taking the power supply guarantee rate and electricity supply continuity as indicators, the system is simulated by using the Transient System Simulator solver. The results show that the recommended installed capacity ratio of the WT and PV is 5:1 when the total solar irradiation is less than 5040 MJ/(m2·a) and the annual average wind velocity is in the range of 3.0~3.5 m/s. When the annual average wind velocity is in the range of 2.0~3.0 m/s, the PV plays an increasingly significant role in the hybrid system and exceeds the WT if the total solar irradiation is greater than 6300 MJ/(m2·a). However, if the total solar irradiation and the annual average wind velocity are less than 5040 MJ/(m2·a) and 2.0 m/s, respectively, it is not recommended to use the standalone hybrid system because it cannot meet the power demand. These conclusions provide guidance for the distribution strategies of the standalone hybrid WT/PV system within different natural resources.
Optimal Reconfiguration of Electrical Distribution System Using Heuristic Methods with Geopositioning Constraints
Authors: Quintana Edy , Inga Esteban
Published: July 2022

Natural disasters have great destructive power and can potentially wipe out great lengths of power lines. A resilient grid can recover from adverse conditions and restore service quickly. Therefore, the present work proposes a novel methodology to reconfigure power grids through graph theory after an extreme event. The least-cost solution through a minimum spanning tree (MST) with a radial topology that connects all grid users is identified. To this end, the authors have developed an iterative minimum-path heuristic algorithm. The optimal location of transformers and maintenance holes in the grid is obtained with the modified Prim algorithm, and the Greedy algorithm complements the process. The span distance and capacity restrictions define the transformer’s number, where larger spans and capacities reduce the number of components in the grid. The performance of the procedure has been tested in the urban zone Quito Tenis of Ecuador, and the algorithm proved to be scalable. Grid reconfiguration is pushed through a powerful tool to model distribution systems such as CYMDIST, where the voltage drops were minor than 3.5%.
Comparative Study of Tectonic Evolution and Oil–Gas Accumulation in the Ri-Qing-Wei Basin and the Jiaolai Basin
Authors: Zhang Yue , Zhou Yaoqi , Zhou Tengfei , Chen Yang , Li Sunyi , Shang Yuehan , Mu Hongyu , Bai Bingyang , Gao Hao , Jing Anyu , Gao Yang , Yang Guojie
Published: July 2022

The Ri-Qing-Wei basin is located in the central Sulu Orogeny on the eastern side of the Tanlu fault zone in eastern Shandong province. To the north, the Jiaonan uplift separates it from the Jiaolai basin, where drilling in the lower Cretaceous sedimentary rock of the Laiyang group has indicated good oil and gas reserves. Drilling in the Ri-Qing-Wei basin, in contrast, is in the preliminary exploration stage. Lingke 1, the only scientific well, is on Lingshan Island on the basin boundary, and it encountered a large set of source rocks 700 m thick. The two basins were comprehensively compared and analyzed based on comprehensive fieldwork, drilling, core data, seismic profiling, sedimentary filling sequence, tectonic evolution history, basin burial history, geothermal history, and geochemical characteristics of the source rocks. The results showed three things: (1) from the late Jurassic to the early Cretaceous (the Laiyang period), subduction of the paleo-Pacific plate under the Eurasian plate delaminated the lithospheric mantle of the Sulu Orogeny, thus forming a series of passive continental rift basins. Of these, the Ri-Qing-Wei is central and the Jiaolai is its branch. After the active rift stage in the Qingshan period and the depression stage in the Wangshi period, the burial depth of the source rocks in the Ri-Qing-Wei basin was up to 6000 m, while the maximum burial depth in the Jiaolai basin was about 3000 m. The paleogeotemperature of both basins exceeded 125 °C, indicating that the source rocks were very mature. (2) A comprehensive comparison of their geochemical characteristics—organic matter abundance, type, and maturity—showed that both basins have oil-generating potential. It is worth noting that the magmatic activity in the Qingshan period had a positive effect on the evolution of the source rocks but was not the key factor: burial depth was. (3) Oil and gas failed to accumulate in the Jiaolai basin because they were destroyed by the lateral tectonic activities. During the right-lateral strike-slip stage (50 ± 5 Ma) during the late Wangshi, the Jiaolai basin was strongly uplifted over a range of more than 1000 m by the Tanlu and Wulian-Mouji fault zones along the boundary. The Wangshi group, as a cap rock, was eroded, and oil and gas overflowed along the fault that reached the surface. The late Wangshi period uplift of the Ri-Qing-Wei basin was less than 1000 m because the source rock was deeper, and the reverse faults in the basin were sealed well. The uplift did little damage to the oil in the Ri-Qing-Wei basin. Above all, tectonic evolution was the main controlling factor of oil accumulation in the study area, and the layers of the Laiyang group in the Ri-Qing-Wei basin have oil and gas potential, making it a prospective target for unconventional offshore oil and gas exploration.
Molecular Basis for Hypochondroplasia in Japan
Authors: Ishii Tomohiro , Takagi Masaki , Nagasaki Keisuke , Ohara Toshio , Miyai Kentaro , Kosho Tomoki , Takada Fumio , Nishimura Gen , Hasegawa Tomonobu
Published: July 2022

Hypochondroplasia is an autosomal dominant genetic disorder due to a heterozygous pathogenic variant of the FGFR3 gene. The early diagnosis of hypochondroplasia is necessary, since growth hormone is effective for improving adult height. The genetic test for the FGFR3 gene could help the early diagnosis. The detailed characteristics of FGFR3 genotypes have not been widely investigated in Japan, except for a common pathogenic variant, p.Asn540Lys. This study retrospectively analyzed the FGFR3 genotypes of 35 patients from 30 families with hypochondroplasia (age, range 0–6 years, median 1 year) in Japan. The pathogenic variants of FGFR3 were identified in all the patients: p.Asn540Lys in 23 probands (76.7%), p.Lys650Gln in 2 (6.7%), p.Leu324His in 2 (6.7%), p.Leu324Val, p.Ser351Cys, and p.Lys650Thr in 1 each (3.2%). The median age at diagnosis, height SD score at diagnosis, or the severity of radiologic findings was not significantly different between probands with p.Asn540Lys and those with other variants. Intellectual disability or epilepsy was identified in seven patients with p.Asn540Lys, but none with other variants. The genetic test of FGFR3 can be useful for assessing the potential risk of neurological sequela in children with hypochondroplasia.
Lyapunov Direct Method for Nonlinear Hadamard-Type Fractional Order Systems
Authors: Dai Changping , Ma Weiyuan
Published: July 2022

In this paper, a rigorous Lyapunov direct method (LDM) is proposed to analyze the stability of fractional non-linear systems involving Hadamard or Caputo–Hadamard derivatives. Based on the characteristics of Hadamard-type calculus, several new inequalities are derived for different definitions. By means of the developed inequalities and modified Laplace transform, the sufficient conditions can be derived to guarantee the Hadamard–Mittag–Leffler (HML) stability of the systems. Lastly, two illustrative examples are given to show the effectiveness of our proposed results.