bluuebunny/crossref_metadata_2025 huggingface dataset:
Quantifying Deaths from Aspergillosis in HIV Positive People
Authors: Denning David W. , Morgan Ellen Frances
Published: October 2022

Aspergillus spp. are ubiquitous and cause severe infections in immunocompromised patients. Less is known about its incidence and prognosis in patients with HIV/AIDS. We reviewed the mortality of invasive aspergillosis in HIV/AIDS patients. Pubmed, Embase and Medline databases were used to search for articles. Studies were excluded if they contained other aspergillosis risk factors, no original or patient survival data or were not in English. From 747 articles published, 54 studies and case reports were identified following reading, published between 1985 and 2021, with 54% papers prior to 2000 reporting 853 patients from 16 countries, none from Africa. 707 (83%) patients died with an average time from diagnosis to death of 77.5 days. Postmortem diagnosis was seen in 21% of deaths recorded. A national series from France of 242 cases of invasive aspergillosis diagnosed in life recorded a 3 month mortality of 68% pre-ART, falling to 31% after introduction of ART and voriconazole. CD4 count was recorded in 39 studies and ranged from 2 to >1000 cells/mm3; only 8 patients (1.8%) had a CD4 > 100 cells/mm3. Aspergillosis occurs in patients with HIV/AIDS and associated with high mortality but its slow progression should allow diagnosis and treatment with improved outcome.
A Retrospective Analysis of the De Ritis Ratio in Muscle Invasive Bladder Cancer, with Focus on Tumor Response and Long-Term Survival in Patients Receiving Neoadjuvant Chemotherapy and in Chemo Naïve Cystectomy Patients—A Study of a Clinical Multicentre Database
Authors: Eriksson Victoria , Holmkvist Oscar , Huge Ylva , Johansson Markus , Alamdari Farhood , Svensson Johan , Aljabery Firas , Sherif Amir
Published: October 2022

Background: A high pre-treatment De Ritis ratio, the aspartate transaminase/alanine aminotransferase ratio, has been suggested to be of prognostic value for mortality in muscle-invasive bladder cancer (MIBC). Our purpose was to evaluate if a high ratio was associated with mortality and downstaging. Methods: A total of 347 Swedish patients with clinically staged T2-T4aN0M0, with administered neoadjuvant chemotherapy (NAC) or eligible for NAC and undergoing radical cystectomy (RC) 2009–2021, were retrospectively evaluated with a low ratio < 1.3 vs. high ratio > 1.3, by Log Rank test, Cox regression and Mann–Whitney U-test (MWU), SPSS 27. Results: Patients with a high ratio had a decrease of up to 3 years in disease-free survival (DFS), cancer-specific survival (CSS) and overall survival (OS) (p = 0.009, p = 0.004 and p = 0.009) and 5 years in CSS and OS (p = 0.019 and p = 0.046). A high ratio was associated with increased risk of mortality, highest in DFS (HR, 1.909; 95% CI, 1.265–2.880; p = 0.002). No significant relationship between downstaging and a high ratio existed (p = 0.564 MWU). Conclusion: A high pre-treatment De Ritis ratio is on a population level, associated with increased mortality post-RC in endpoints DFS, CSS and OS. Associations decrease over time and require further investigations to determine how strong the associations are as meaningful prognostic markers for long-term mortality in MIBC. The ratio is not suitable for downstaging-prediction.
Anti-TNFα Drugs and Interleukin Inhibitors: Epidemiological and Pharmacovigilance Investigation in COVID-19 Positive Patients
Authors: Maraia Zaira , Mazzoni Tony , Rocchi Marco Bruno Luigi , Feliciani Denise , Romani Maria Chiara , Acciarri Giovanna , Rafaiani Stefania , Mazzoni Isidoro
Published: October 2022

Cytokine patterns and immune activation in patients with Coronavirus 2019 (COVID-19) seem to resemble the case of rheumatoid arthritis (RA), psoriasis and inflammatory bowel disease (IBD). Biological drugs, such as anti-tumor necrosis factor α (TNFα) and interleukin (IL) inhibitors, appear to be protective against adverse outcomes of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). However, these treatments are associated with an increased risk of secondary infections. The aim of the study was to examine the association between the use of immunomodulatory drugs and the risk of SARS-CoV-2-associated positivity, hospitalization and death compared to other commonly prescribed treatment regimens among patients with immune-mediated inflammatory diseases. Methods: All patients with RA, Psoriasis and IBD were included in this observational analysis and treated with anti-TNFα, IL-inhibitors, Methotrexate (MTX) and Sulfasalazine drugs during the year 2020–2021. The population consisted of 932 patients and demographic, clinical and pharmacological data were analyzed. Results: Although no significant differences were observed between patients treated with biological and synthetic drugs in terms of hospitalization and death, the multivariate logistic model showed that the type of drug influences the possibility of COVID-19 positivity. Conclusions: The results of this analysis support the use of biological drugs and justify further research investigating the association of these biological therapies with COVID-19 outcomes.
Carry Trade and Capital Market Returns in South Africa
Authors: Bonga-Bonga Lumengo , Rangoanana Sefora Motena
Published: October 2022

This paper assesses the extent to which carry trade operations affect the performance of equity and bond markets in a target country, South Africa, by considering the US and the euro area as the funding countries. A two- and three-factor capital asset pricing model (CAPM) is employed to assess whether the pricing of equity and bond markets in South Africa depends on the US dollar/rand and euro/rand carry trade returns. Moreover, the paper uses the quantile regression technique to assess whether this pricing varies with the distribution of the equity and bond returns. The findings support that the US- and euro-funded carry trade are essential factors for the pricing of equity and bond markets in South Africa. Moreover, the results of the two-factor model show a negative relationship between the equity excess return and the US-carry trade returns at lower quantiles of the equity market returns. The positive relationship is observed in the upper quantiles of the equity market. The negative relationship means that carry trade activities reduce equity market returns during a bear market as investors close out their position when conditions in the equity market become unfavourable. The results of the three-factor model, controlling for the global volatility or uncertainty, show that carry trade investors exit the equity market to invest in the bond market when global uncertainty rises. This finding shows that carry trade investors choose less risky assets during rising global uncertainty.
Exosomes in Neuroblastoma Biology, Diagnosis, and Treatment
Authors: Jahangiri Leila , Ishola Tala
Published: October 2022

Neuroblastoma is an extracranial solid tumour of the developing sympathetic nervous system accounting for circa 15% of deaths due to cancer in paediatric patients. The clinical course of this cancer may be variable, ranging from aggressive progression to regression, while the amplification of MYCN in this cancer is linked to poor patient prognosis. Extracellular vesicles are a double membrane encapsulating various cellular components including proteins and nucleic acids and comprise exosomes, apoptotic bodies, and microvesicles. The former can act as mediators between cancer, stromal and immune cells and thereby influence the tumour microenvironment by the delivery of their molecular cargo. In this study, the contribution of extracellular vesicles including exosomes to the biology, prognosis, diagnosis and treatment of neuroblastoma was catalogued, summarised and discussed. The understanding of these processes may facilitate the in-depth dissection of the complexity of neuroblastoma biology, mechanisms of regression or progression, and potential diagnostic and treatment options for this paediatric cancer which will ultimately improve the quality of life of neuroblastoma patients.
Candidate Multi-Epitope Vaccine against Corona B.1.617 Lineage: In Silico Approach
Authors: Seadawy Mohamed G. , Zekri Abdel Rahman N. , Saeed Aya A. , San Emmanuel James , Ageez Amr M.
Published: October 2022

Various mutations have accumulated since the first genome sequence of SARS-CoV2 in 2020. Mutants of the virus carrying the D614G and P681R mutations in the spike protein are increasingly becoming dominant all over the world. The two mutations increase the viral infectivity and severity of the disease. This report describes an in silico design of SARS-CoV-2 multi-epitope carrying the spike D614G and P681R mutations. The designed vaccine harbors the D614G mutation that increases viral infectivity, fitness, and the P681R mutation that enhances the cleavage of S to S1 and S2 subunits. The designed multi-epitope vaccine showed an antigenic property with a value of 0.67 and the immunogenicity of the predicted vaccine was calculated and yielded 3.4. The vaccine construct is predicted to be non-allergenic, thermostable and has hydrophilic nature. The combination of the selected CTL and HTL epitopes in the vaccine resulted in 96.85% population coverage globally. Stable interactions of the vaccine with Toll-Like Receptor 4 were tested by docking studies. The multi-epitope vaccine can be a good candidate against highly infecting SARS-CoV-2 variants.
Technology for Obtaining the Approximate Value of Moving Singular Points for a Class of Nonlinear Differential Equations in a Complex Domain
Authors: Orlov Victor , Gasanov Magomedyusuf
Published: October 2022

In previous studies, the authors formulated precise criteria for finding moving singular points of one class of nonlinear differential equations with a second degree polynomial right-hand side for a real domain. In this paper, the authors generalize these exact criteria to a complex one by using phase spaces. The proposed technology for obtaining an approximate value of moving singular points is necessary for developing PC programs. This technology has been tested in a manual version based on a numerical experiment.
Identification of Barriers Preventing Biosimiliar Oncology Medication Adoption
Authors: Hair John , Maryon Thomas , Lieneck Cristian
Published: October 2022

(1) Background: A biosimilar is a biologic medical product that has been approved by the United States Food and Federal Drug Administration (FDA) and is an almost identical copy of an original biologic product yet manufactured by a different company. Biosimilars are often assumed to be the same as generic medications, while often made from living organisms. Through clinical trials, biosimilars have been shown to be both as safe and as effective as their originator products. Biosimilars have also proven they can reduce the costs to both insurance companies and patients in many circumstances. However, despite their cost savings, biosimilar manufacturers continue to face barriers in having oncologists and cancer centers prescribe them for their patients. This review aims to identify barriers associated with medical provider prescriptive behaviors related to biosimilars for patients. (2) Methods: Reviewers analyzed 27 articles and identified common themes. (3) Results: After a thorough literature review, the researchers identified seven barriers to prescribing of biosimilars: physician comfort in originators instead of biosimilars, patient reluctance to switch from a current biologic to a biosimilar, provider profits associated with an originator biologic, lack of stakeholder education on biosimilars, lack of provider team knowledge of biosimilars, lack of knowledge surrounding the biosimilar FDA approval process, and hesitancy to stock multiple drugs for a specific indication. (4) Conclusions: This review’s findings of identified barriers to use of biosimilars provides insight for healthcare providers and organizations surrounding prescribing practices and potential treatment benefits for cancer patients who may benefit from biosimilar treatment medications.
Antimicrobial Properties of a Copper/Silicone Composite Membrane Prepared Using a Two-Step Immersion Process in Iodine and Copper Sulfate Solutions
Authors: Takeshita Junpei , Aoki Shiho , Wada Risei , Osawa Ayako , Sawai Jun
Published: October 2022

Silicone (polydimethylsiloxane) materials are widely used in various applications. Due to microbe adherence and biofilm formation at the surface of silicone materials, silicone materials must possess antibacterial properties. To achieve this, we prepared copper (Cu)–silicone composite membranes using a simple two-step process of immersion in iodine and copper sulfate solutions. Subsequent scanning electron microscopy revealed Cu nanoparticles (CuNPs) of 10 to 200 nanometers in diameter on the silicone membrane surface, which were identified as copper iodide using energy-dispersive X-ray spectroscopy. The mechanical strength of the material did not change significantly as a result of the two-step immersion treatment and the Cu/silicone membrane showed excellent antibacterial efficacy against Escherichia coli and Staphylococcus aureus, maintaining R > 2 even after a physical impact such as stomacher treatment. Additionally, the Cu ions eluted from the Cu/silicone membrane remained at very low concentrations, suggesting firm immobilization of CuNPs on the silicone membrane. This proposed antimicrobial treatment method does not require special equipment, can be performed at room temperature, and has the potential for use on silicone materials other than membranes.
Exosomes as New Generation Vehicles for Drug Delivery: Biomedical Applications and Future Perspectives
Authors: Rajput Amarjitsing , Varshney Akansh , Bajaj Rashi , Pokharkar Varsha
Published: October 2022

Currently, particular interest among the scientific community is focused on exploring the use of exosomes for several pharmaceutical and biomedical applications. This is due to the identification of the role of exosomes as an excellent intercellular communicator by delivering the requisite cargo comprising of functional proteins, metabolites and nucleic acids. Exosomes are the smallest extracellular vesicles (EV) with sizes ranging from 30–100 nm and are derived from endosomes. Exosomes have similar surface morphology to cells and act as a signal transduction channel between cells. They encompass different biomolecules, such as proteins, nucleic acids and lipids, thus rendering them naturally as an attractive drug delivery vehicle. Like the other advanced drug delivery systems, such as polymeric nanoparticles and liposomes to encapsulate drug substances, exosomes also gained much attention in enhancing therapeutic activity. Exosomes present many advantages, such as compatibility with living tissues, low toxicity, extended blood circulation, capability to pass contents from one cell to another, non-immunogenic and special targeting of various cells, making them an excellent therapeutic carrier. Exosome-based molecules for drug delivery are still in the early stages of research and clinical trials. The problems and clinical transition issues related to exosome-based drugs need to be overcome using advanced tools for better understanding and systemic evaluation of exosomes. In this current review, we summarize the most up-to-date knowledge about the complex biological journey of exosomes from biogenesis and secretion, isolation techniques, characterization, loading methods, pharmaceutical and therapeutic applications, challenges and future perspectives of exosomes.
Magnetically Driven Muco-Inert Janus Nanovehicles for Enhanced Mucus Penetration and Cellular Uptake
Authors: Hao Yue , Bai Shu , Yu Linling , Sun Yan
Published: October 2022

One of the main challenges of transmucosal drug delivery is that of enabling particles and molecules to move across the mucosal barrier of the mucosal epithelial surface. Inspired by nanovehicles and mucus-penetrating nanoparticles, a magnetically driven, mucus-inert Janus-type nanovehicle (Janus-MMSN-pCB) was fabricated by coating the zwitterionic polymer poly(carboxybetaine methacrylate) (pCB) on the mesoporous silica nanorod, which was grown on one side of superparamagnetic Fe3O4 nanoparticle using the sol–gel method. X-ray diffraction, transmission electron microscopy, vibrating sample magnetometry, and Fourier infrared spectroscopy were used to characterize the structure and morphology of the nanovehicles, proving the success of each synthesis step. The in vitro cell viability assessment of these composites using Calu-3 cell lines indicates that the nanovehicles are biocompatible in nature. Furthermore, the multiparticle tracking, Transwell® system, and cell imaging experimental results demonstrate that both the modification of pCB and the application of a magnetic field effectively accelerated the diffusion of the nanovehicles in the mucus and improved the endocytosis through Calu-3. The favorable cell uptake performance of Janus-MMSN-pCB in mucus systems with/without magnetic driving proves its potential role in the diagnosis, treatment, and imaging of mucosal-related diseases.
Carbon Quantum Dots Bridged TiO2/CdIn2S4 toward Photocatalytic Upgrading of Polycyclic Aromatic Hydrocarbons to Benzaldehyde
Authors: Zhang Jiangwei , Yu Fei , Ke Xi , Yu He , Guo Peiyuan , Du Lei , Zhang Menglong , Luo Dongxiang
Published: October 2022

Conversion of hazardous compounds to value-added chemicals using clean energy possesses massive industrial interest. This applies especially to the hazardous compounds that are frequently released in daily life. In this work, a S-scheme photocatalyst is optimized by rational loading of carbon quantum dots (CQDs) during the synthetic process. As a bridge, the presence of CQDs between TiO2 and CdIn2S4 improves the electron extraction from TiO2 and supports the charge transport in S-scheme. Thanks to this, the TiO2/CQDs/CdIn2S4 presents outstanding photoactivity in converting the polycyclic aromatic hydrocarbons (PAHs) released by cigarette to value-added benzaldehyde. The optimized photocatalyst performs 87.79% conversion rate and 72.76% selectivity in 1 h reaction under a simulated solar source, as confirmed by FT-IR and GC-MS. A combination of experiments and theoretical calculations are conducted to demonstrate the role of CQDs in TiO2/CQDs/CdIn2S4 toward photocatalysis.
Special Issue “Applications of Stable Isotope Analysis”
Authors: Herrera-Herrera Antonio V. , Jambrina-Enríquez Margarita
Published: October 2022

The isotopic composition of matter is controlled by different physical, chemical, and biological mechanisms [...]
Lights on for Autism: Exploring Photobiomodulation as an Effective Therapeutic Option
Authors: Hamilton Catherine , Liebert Ann , Pang Vincent , Magistretti Pierre , Mitrofanis John
Published: October 2022

Autism is a neurodevelopmental condition that starts in childhood and continues into adulthood. The core characteristics include difficulties with social interaction and communication, together with restricted and repetitive behaviours. There are a number of key abnormalities of brain structure and function that trigger these behavioural patterns, including an imbalance of functional connectivity and synaptic transmission, neuronal death, gliosis and inflammation. In addition, autism has been linked to alterations in the gut microbiome. Unfortunately, as it stands, there are few treatment options available for patients. In this mini-review, we consider the effectiveness of a potential new treatment for autism, known as photobiomodulation, the therapeutic use of red to near infrared light on body tissues. This treatment has been shown in a range of pathological conditions-to improve the key changes that characterise autism, including the functional connectivity and survival patterns of neurones, the patterns of gliosis and inflammation and the composition of the microbiome. We highlight the idea that photobiomodulation may form an ideal treatment option for autism, one that is certainly worthy of further investigation.
Development and Validation of an Anthropometric Equation to Predict Fat Mass Percentage in Professional and Semi-Professional Male Futsal Players
Authors: Giro Rita , Matias Catarina N. , Campa Francesco , Santos Diana A. , Cavaca Margarida L. , Duque Pedro , Oliveira Marco , Matos Nuno , Vicente Filipa , Pereira Paula , Santos Heitor O. , Tinsley Grant M. , Teixeira Filipe J.
Published: October 2022

This study aimed to (i) characterise the body composition of professional and semi-professional male futsal players, (ii) assess the validity of commonly used equations to estimate FM%, (iii) develop and cross-validate a futsal-specific FM% prediction equation. In a cross-sectional design, 78 adult male futsal players were assessed for body mass, stature, skinfolds, and girths as per the International Society for the Advancement of Kinanthropometry protocol and completed a dual-energy X-ray absorptiometry (DXA) scan for reference body composition data. Using paired-sample t-tests, the FM% from the DXA and nine published equations were compared. New sport-specific models were developed by stepwise multiple regression. Existing equations were cross-validated using the least squares regression, concordance correlation coefficient, and the Bland–Altman analyses. New equations were further cross-validated using the PRESS approach. None of the existing equations accurately predicted the DXA-derived FM% (p < 0.001; R2 ≤ 0.76, SEE ≥ 1.59; CCC ≤ 0.83; bias = −8.2% to −1.3%, limited agreement, and varying trends). The novel Bettery® equation: −0.620 + (0.159 ∗ Σ4SKF [triceps, abdominal, iliac crest, and front thigh (mm)]) + (0.120 ∗ waist girth (cm)), demonstrated a high accuracy (R2 = 0.85, SEE = 1.32%), a moderate strength of agreement (CCC = 0.92), no bias (0.2%), good agreement (±2.5%), and no trend (r = −0.157; p = 0.170) against the DXA. The Bettery® equation is the first to allow for a valid and sport-specific assessment of FM% in male futsal players.
In Vitro Cytotoxic Activity of Methanol Extracts of Selected Medicinal Plants Traditionally Used in Mexico against Human Hepatocellular Carcinoma
Authors: Elizondo-Luévano Joel H. , Gomez-Flores Ricardo , Verde-Star María J. , Tamez-Guerra Patricia , Romo-Sáenz César I. , Chávez-Montes Abelardo , Rodríguez-Garza Nancy E. , Quintanilla-Licea Ramiro
Published: October 2022

Medicinal plants are traditionally used in Mexico to treat diseases such as cancer. The present study aimed to evaluate the cytotoxic, antioxidant, and anti-hemolytic activity of 15 plants of ethnopharmacological use in Mexico. For this, plant methanol extracts were prepared by the Soxhlet method, after which their cytotoxic activity was evaluated against human hepatocellular carcinoma (HEP-G2) and monkey kidney epithelial (Vero) cells by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction colorimetric assay. The selectivity index (SI) of each extract was then determined by the IC50 ratio of normal to tumor cells. We showed that Ruta chalepensis extract possessed an IC50 of 1.79 µg/mL and 522.08 µg/mL against HEP-G2 and Vero cells, respectively, resulting in an SI of 291.50. Furthermore, antioxidant activity was evaluated by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging technique, where the best antioxidant potential was shown by the Heterotheca inuloides extract (IC50 = 19.24 µg/mL). Furthermore, the hemolytic potential was determined against human erythrocytes, which showed that the extracts with the highest anti-hemolytic activity were Smilax aspera (IC50 = 4.41 µg/mL) and Amphipterygium adstringens (IC50 = 5.35 µg/mL). In conclusion, we observed that R. chalepensis methanol extract possesses cytotoxic activity against HEP-G2 cells, without affecting non-tumorigenic Vero cells. Our results indicated the antitumor potential of medicinal plants used in Mexico.
Antibiotics in the Environment: Prescribing Risks to Non-Target Organisms
Authors: da Silva Freitas Livia , Honscha Laiz Coutelle , Volcão Lisiane Martins , de Lima Brum Rodrigo , da Silva Júnior Flavio Manoel Rodrigues , Ramos Daniela Fernandes
Published: October 2022

Background: The cephalosporins class is among the most widely used group of antimicrobials worldwide. Antibiotics, together with other drugs and personal care products, make up a group of emerging contaminants. The effects of exposure to this group of chemical contaminants on non-target organisms are not well understood, as they are still poorly studied. Therefore, this study evaluated the phytotoxicity of five cephalosporins in Lactuca sativa. Methods: Lettuce seeds were exposed to different concentrations of antibiotics (25 to 500 mg/L) for 5 days in the dark. After this period, the germination percentage and the wet and dry weights were recorded. Results: The highest tested concentration (500 mg/L) inhibited the germination of lettuce seeds (p < 0.05); there was a decrease in dry weight when exposed to a first-generation cephalosporin (p < 0.05). Additionally, there was a significantly negative influence (p < 0.05) on the fresh weight, especially in the group that evaluated the exposure of seeds to 25 mg/L of Cefepime. Conclusions: We emphasize that there is no record of environmental concentrations of cephalosporins in soil, and therefore, we can indicate that it is possible to have environmental damage resulting from the inappropriate and constant disposal of cephalosporins in the environment.
Phosphazene-Containing Epoxy Resins Based on Bisphenol F with Enhanced Heat Resistance and Mechanical Properties: Synthesis and Properties
Authors: Tarasov Ilya V. , Oboishchikova Anastasiya V. , Borisov Roman S. , Kireev Vyacheslav V. , Sirotin Igor S.
Published: October 2022

Organophosphazenes are of interest due to the combination of increased mechanical and thermal properties of polymer materials obtained with their use, however, they are characterized by a complex multi-stage synthesis. Moreover, the high viscosity of phosphazene-containing epoxy resins (PhER) makes their processing difficult. To simplify the synthesis of PhER, a one-step method was developed, and bisphenol F was chosen, which also provided a decrease in viscosity. In the current study, PhER were formed by a one-stage interaction of hexachlorocyclotriphosphazene (HCP) with bisphenol F isomers and epichlorohydrin in the presence of alkali, which was a mixture of epoxycyclophosphazenes (ECPh) with a functionality from 1 to 4 according to the results of MALDI-TOF analysis. Conventional epoxy resins based on bisphenol F, also formed during the process, showed high mechanical properties and glass transition temperature, and the reactivity of the obtained resins is similar to the base epoxy resins based on bisphenols A and F. Cured PhER had higher or the same mechanical properties compared to base epoxy resins based on bisphenol A and F, and a glass transition temperature comparable to base epoxy resins based on bisphenol F: glass transition temperature (Tg) up to 174.5 °C, tensile strength up to 74.5 MPa, tensile modulus up to 2050 MPa, tensile elongation at break up to 6.22%, flexural strength up to 146.6 MPa, flexural modulus up to 3630 MPa, flexural elongation at break up to 9.15%, and Izod impact strength up to 4.01 kJ/m2. Analysis of the composition of the obtained PhER was carried out by 1H and 31P NMR spectroscopy, MALDI-TOF mass spectrometry, X-ray fluorescence elemental analysis, and contained up to 3.9% phosphorus and from 1.3% to 4.2% chlorine. The temperature profile of the viscosity of the resulting epoxy resins was determined, and the viscosity at 25 °C ranged from 20,000 to 450,000 Pa·s, depending on the ratio of reagents. The resins studied in this work can be cured with conventional curing agents and, with a low content of the phosphazene fraction, can act as modifiers for traditional epoxy resins, being compatible with them, to increase impact strength and elasticity while maintaining the rest of the main mechanical and processing properties, and can be used as a resin component for composite materials, adhesives, and paints.
Study of Sea Surface Geophysical Parameter Changes Due to Internal Solitary Waves Using a Sentinel-3 Synthetic Aperture Radar Altimeter
Authors: Yu Changtian , Meng Junmin , Sun Lina , Zhang Hao , Wang Haiqi
Published: October 2022

In this paper, a high-resolution Sentinel-3 synthetic aperture radar altimeter is used to observe ISWs in the Sulu Sea. Based on the advantages of the simultaneous observation of Sentinel-3 OLCI and SRAL, the changes in σ0, SWH, and SSHA caused by the ISWs are quantitatively analyzed. The results show that σ0 decreases and then increases after being modulated by the ISWs in the altimeter operation direction; SWH shows a large change; and the change trend of SSHA is the same as that of σ0. Because of the angle between the propagation direction of the ISWs and the SRAL trajectory, the actual position corresponding to the peak power in the waveform detects the ISWs before the nadir, at which time σ0 is already modulated by ISWs, resulting in the deviation of σ0. In addition, the sea surface roughness within the SRAL footprint in this case is no longer uniform, which violates the assumption of retracking and leads to the incorrect estimation of geophysical parameters such as SWH and SSHA. With a view to correcting these errors, the effect of ISWs on the retracker must therefore be considered and the model for waveform modified accordingly.
Disentangling Housing Supply to Shift towards Smart Cities: Analysing Theoretical and Empirical Studies
Authors: Garcês Pedro , Pires Cesaltina Pacheco , Costa Joana , Jorge Sílvia Ferreira , Catalão-Lopes Margarida , Alventosa Adriana
Published: October 2022

The search for a pleasant home has concerned people ever since. Paradoxically, people are facing strong difficulties in finding a decent place to settle their lives in cities. As such, the housing market regained momentum in connection with the development of Smart Cities, where life quality of residents is strongly emphasized. Well-being in the metropolis is affected by a wide variety of factors with housing supply being among the most important, hence stirred by financing costs, construction costs, vacancy rate, sales delay, inflation rate, housing stock, price of agricultural land, and regulation. The present article reviews empirical studies on housing supply for a better understanding of the dynamics in this market, shedding some light on the expectable outcomes of policy actions in the promotion of sustainable housing towards the smart city transition. Our review shows that the long-run price elasticity of housing supply is larger than the short-run, as well as the existence of substantial differences in the price elasticity across countries and regions. As such, overall, the hypothesis of a perfectly elastic supply is rejected. In addition, our review highlights that housing supply is negatively related to financial costs, inflation, sales delay, and the existence of regulatory or physical constraints. Also, the elasticity is lower when there are regulatory constraints. Newfangled strategic interaction models, though overlooked in the literature, reinforce that housing does not fit the perfect competition frame. The review proves that we are in face of a non-competitive market in which policy intervention is required to maximize social welfare; policy packages to grant people access to the housing market may be required. However, policy interventions should be carefully designed and clear, to mitigate their potentially negative impact on the housing supply as adverse results may be harmful to the transition towards a smart city.
The Significance of Urban Rail Transit Systems in Mitigating Air Pollution Effects: The Case of China
Authors: Sun Jing , Sial Muhammad Safdar , Deng Dasong , Saxunova Darina , Haider Ahsanuddin , Khan Mohammed Arshad
Published: October 2022

Air pollution is a global problem and the transportation industry is one of its major causes, yet the impact of transportation infrastructure on air quality is little understood. It is vital to know about evaluating the effects of transportation infrastructure on air quality. The urban road has a role in defining air pollution and automobiles significantly contribute to the air quality in urban areas. The issues are a result of the automobile’s impact on air quality. China put substantial investments in its metropolitan subway networks. The information on air quality on an hourly basis, daily metrological data, and demographic profiles of various cities with significant subways from the year 2013 to the year 2014 used. This study examines the effect of substantial investment on urban air quality. The Discontinuity Based Ordinary Least Squares (DB-OLS) on data for further analysis with results are incorporated in the study. The researchers witnessed a 14% reduction in air pollution during the daytime in those not rushed cities. Researchers discovered that the impacts are less severe in urban areas with a lower population density and a higher income. The results will be less dangerous if more subways affect the air quality.
What Is the Policy Effect of Coupling the Green Hydrogen Market, National Carbon Trading Market and Electricity Market?
Authors: Wang Hao-Ran , Feng Tian-Tian , Li Yan , Zhang Hui-Min , Kong Jia-Jie
Published: October 2022

Green hydrogen has become the key to social low-carbon transformation and is fully linked to zero carbon emissions. The carbon emissions trading market is a policy tool used to control carbon emissions using a market-oriented mechanism. Building a modular carbon trading center for the hydrogen energy industry would greatly promote the meeting of climate targets. Based on this, a “green hydrogen market—national carbon trading market–electricity market” coupling mechanism is designed. Then, the “green hydrogen market—national carbon trading market–electricity market” mechanism is modeled and simulated using system dynamics. The results are as follows: First, coupling between the green hydrogen market, carbon trading market and electricity market can be realized through green hydrogen certification and carbon quota trading. It is found that the coupling model is feasible through simulation. Second, simulation of the basic scenario finds that multiple-market coupling can stimulate an increase in carbon price, the control of thermal power generation and an increase in green hydrogen production. Finally, the proportion of the green hydrogen certification, the elimination mechanism of outdated units and the quota auction mechanism will help to form a carbon pricing mechanism. This study enriches the green hydrogen trading model and establishes a multiple-market linkage mechanism.
Observe Gamma-Rays and Neutrinos Associated with Ultra-High Energy Cosmic Rays
Authors: Zhang Qinyuan , Tian Xishui , Li Zhuo
Published: October 2022

IceCube measures a diffuse neutrino flux comparable to the Waxman-Bahcall bound, which suggests the possibility that the ultra-high energy cosmic rays (UHECRs) have a common origin with diffuse high energy neutrinos. We propose high energy gamma-ray and/or neutrino observations toward the arrival directions of UHECRs to search for the sources and test this possibility. We calculate the detection probability of gamma-ray/neutrino sources, and find that the average probability per UHECR of >10 EeV is ∼10% if the sensitivity of the gamma-ray or neutrino telescope is ∼10−12 erg cm−2 s−1 and the source number density is ∼10−5 Mpc−3. Future gamma-ray and neutrino observations toward UHECRs, e.g., by LHAASO-WCDA, CTA, IceCube/Gen2, are encouraged to constrain the density of UHECR sources or even identify the sources of UHECRs.
Launching the VASCO Citizen Science Project
Authors: Villarroel Beatriz , Pelckmans Kristiaan , Solano Enrique , Laaksoharju Mikael , Souza Abel , Dom Onyeuwaoma Nnaemeka , Laggoune Khaoula , Mimouni Jamal , Guergouri Hichem , Mattsson Lars , García Aurora Lago , Soodla Johan , Castillo Diego , Shultz Matthew E. , Aworka Rubby , Comerón Sébastien , Geier Stefan , Marcy Geoffrey W. , Gupta Alok C. , Bergstedt Josefine , Bär Rudolf E. , Buelens Bart , Enriquez Emilio , Mellon Christopher K. , Prieto Almudena , Wamalwa Dismas Simiyu , de Souza Rafael S. , Ward Martin J.
Published: October 2022

The Vanishing & Appearing Sources during a Century of Observations (VASCO) project investigates astronomical surveys spanning a time interval of 70 years, searching for unusual and exotic transients. We present herein the VASCO Citizen Science Project, which can identify unusual candidates driven by three different approaches: hypothesis, exploratory, and machine learning, which is particularly useful for SETI searches. To address the big data challenge, VASCO combines three methods: the Virtual Observatory, user-aided machine learning, and visual inspection through citizen science. Here we demonstrate the citizen science project and its improved candidate selection process, and we give a progress report. We also present the VASCO citizen science network led by amateur astronomy associations mainly located in Algeria, Cameroon, and Nigeria. At the moment of writing, the citizen science project has carefully examined 15,593 candidate image pairs in the data (ca. 10% of the candidates), and has so far identified 798 objects classified as “vanished”. The most interesting candidates will be followed up with optical and infrared imaging, together with the observations by the most potent radio telescopes.
COVID-19 Vaccination in Kidney Transplant Candidates and Recipients
Authors: Ponticelli Claudio , Campise Mariarosaria
Published: October 2022

Kidney transplant candidates and kidney transplant recipients (KTRs) are at particular risk of severe complications of COVID-19 disease. In Western countries, mortality in affected hospitalized KTRs ranges between 19% and 50%. COVID-19 vaccination remains the most important measure to prevent the severity of infection in candidates and recipients of kidney transplant. However, the uraemic condition may affect the vaccine-induced immunity in patients with advanced chronic kidney disease (CKD) and in KTRs. Retention of uraemic toxins, dysbiosis, dysmetabolism, and dialysis can diminish the normal response to vaccination, leading to dysfunction of inflammatory and immune cells. In KTRs the efficacy of vaccines may be reduced by the immunosuppressive medications, and more than half of kidney transplant recipients are unable to build an immune response even after four administrations of anti-COVID-19 vaccines. The lack of antibody response leaves these patients at high risk for SARS-CoV-2 infection and severe COVID-19 disease. The aim of the present review is to focus on the main reasons for the impaired immunological response among candidates and kidney transplant recipients and to highlight some of the present options available to solve the problem.
Differential Kinetics of Effector and Memory Responses Induced by Three Doses of SARS-CoV-2 mRNA Vaccine in a Cohort of Healthcare Workers
Authors: Bergami Federica , Arena Francesca , Sammartino Josè Camilla , Ferrari Alessandro , Zavaglio Federica , Zelini Paola , Paolucci Stefania , Comolli Giuditta , Percivalle Elena , Lilleri Daniele , Cassaniti Irene , Baldanti Fausto
Published: October 2022

We reported the long-term kinetics of immune response after vaccination and evaluated the immunogenicity after a third dose of mRNA vaccine in 86 healthcare workers. Humoral response was analyzed by measuring anti-spike IgG and SARS-CoV-2 NTAbs titer; cell-mediated response was measured as frequency of IFN-γ producing T-cells and cell proliferation. Memory B cells secreting SARS-CoV-2 RBD-IgG were measured by B-spot assay. At three weeks after the third dose (T4), the frequency of subjects showing NT-Abs titer at the upper detection limit (≥640) was significantly higher than that observed at three weeks after the second dose (26/77; 33.7% vs. 9/77; 11.6%; p = 0.0018). Additionally, at T4, all the subjects reached positive levels of T-cell mediated response (median 110 SFU/106 PBMC, IQR 73-231). While the number of IFNγ-producing T-cells decreased between second and third dose administration, the T-cell proliferative response did not decrease but was sustained during the follow-up. Among T-cell subsets, a higher proliferative response was observed in CD4+ than in CD8+ population. Moreover, even if a decline in antibody response was observed between the second and third dose, a sustained persistence of memory B cells was observed. Subsequently, the third dose did not affect the frequency of memory B cells, while it restored or increased the peak antibody levels detected after the second dose.
Genetic Characteristics of Canine Adenovirus Type 2 Detected in Wild Raccoon Dogs (Nyctereutes procyonoides) in Korea (2017–2020)
Authors: Kim Yoon-Ji , Lee Sook-Young , Kim Young-Sik , Na Eun-Jee , Park Jun-Soo , Oem Jae-Ku
Published: October 2022

Adenovirus has been detected in a wide range of hosts like dogs, foxes, horses, bats, avian animals, and raccoon dogs. Canine adenoviruses with two serotypes host mammals and are members of the mastadenovirus family. Canine adenovirus type 1 (CAdV-1) and canine adenovirus type 2 (CAdV-2) cause infectious canine hepatitis and infectious bronchial disease, respectively. In this study, we investigated the prevalence of CAdV-1 and 2 in wild Nyctereutes procyonoides in Korea in 2017–2020 from 414 tissue samples, including the liver, kidney, lung, and intestine, collected from 105 raccoon dog carcasses. Only CAdV-2 was detected in two raccoon dogs, whereas CAdV-1 was not detected. Tissue samples from raccoon dogs were screened for CAdV-1 and CAdV-2 using conventional PCR. Adenovirus was successfully isolated from PCR positive samples using the Vero cell line, and the full-length gene sequence of the isolated viruses was obtained through 5’ and 3’ rapid amplification of cDNA ends (RACE). The major genes of the isolated CAdV-2/18Ra54 and CAdV-2/18Ra-65 strains showed the closest relationship with that of the CAdV-2 Toronto A26/61 strain isolated from Canada in 1976. There is no large mutation between CAdV-2, which is prevalent worldwide, and CAdV-2, which is prevalent in wild animals in Korea. In addition, it is still spreading and causing infections. The Toronto A26/61 strain, which showed the most similarity to CAdV-2/18Ra-54, was likely transmitted to wild animals through vaccinated companion animals, suggesting that further research is needed on safety measures surrounding animal vaccination. This study provides information on the genetic characteristics and prevalence of canine adenovirus in domestic wild animals and provides a better understanding of canine adenovirus.
Monitored and Intentional Recharge (MIR): A Model for Managed Aquifer Recharge (MAR) Guideline and Regulation Formulation
Authors: Fernández Escalante Enrique , Henao Casas José David , San Sebastián Sauto Jon , Calero Gil Rodrigo
Published: October 2022

Guidelines and regulatory frameworks for conducting managed aquifer recharge (MAR) are scarce worldwide compared to the countries where MAR projects operate. At the same time, guidelines and regulations are crucial to implementing MAR activities safely, respecting human health and the environment, and guaranteeing the sustainability of the intentional recharge. The present study aims to provide a conceptual model comprising the minimum elements to consider when drafting guiding and normative MAR documents. To this end, aspects discussed in nine guidelines were evaluated through a score that allowed their significance to be assessed. The authors also reviewed 22 regulations, guidelines, or MAR site operation rules to construct the monitored and intentional recharge (MIR) conceptual model. This effort was enhanced by active participation in the real drafting of two national regulating documents for MAR. The evaluation of aspects in the documents showed the importance of water reuse and risk and impact assessment. The MIR conceptual model comprises nine blocks that summarize the most important aspects to consider. This conceptual model, which guides MAR regulations in two countries, has great potential for application in different sites under diverse contexts.
Quality management of healthy foods for vegetarians
Authors:   Department of Commodity Science and Commodity Expert Examination, Plekhanov Russian University of Economics, Eliseeva L.G. , Agafonov A.V. ,   Department of Commodity Science and Commodity Expert Examination, Plekhanov Russian University of Economics, Molodkina P.G. ,   Department of Commodity Science and Commodity Expert Examination, Plekhanov Russian University of Economics, Santuryan T.A. ,   Department of Commodity Science and Commodity Expert Examination, Plekhanov Russian University of Economics
Published: October 2022

The analysis of physiological and hygienic aspects and possible risks of vegetarian diets was carried out. Market development trends and the range of new food products for vegetarian nutrition manufactured using meat products analogues based on vegetable structured proteins have been studied. The results of a comparative analysis of the organoleptic indicators of quality and nutritional value of vegan cutlets of the main Russian producers are presented. The main trends in the management of the quality and assortment of meat products analogues using vegetable proteins are determined.
Purpose classification of needs satisfied by services
Authors:   Department of International Commerce, Russian Presidential Academy of National Economy and Public Administration, Nikolaeva M.A. , Kalachev S.L. ,   Department of Commodity Science and Commodity Expert Examination, Plekhanov Russian University of Economics
Published: October 2022

The article presents an innovative classification of needs satisfied by services according to functional and social purpose. The types and subtypes of these needs are considered. It was found that services and their material results satisfy mainly physiological, mental, socio-economic, and intellectual needs, and to a lesser extent — spiritual, mainly religious needs. For each type, the paper examines the subtypes and means of satisfaction: services, their tangible and intangible results, as well as the conditions for the provision of services.