bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table 7 from Genome and Transcriptome Sequencing in Prospective Metastatic Triple-Negative Breast Cancer Uncovers Therapeutic Vulnerabilities
Authors: Craig David W. , O'Shaughnessy Joyce A. , Kiefer Jeffrey A. , Aldrich Jessica , Sinari Shripad , Moses Tracy M. , Wong Shukmei , Dinh Jennifer , Christoforides Alexis , Blum Joanne L. , Aitelli Cristi L. , Osborne Cynthia R. , Izatt Tyler , Kurdoglu Ahmet , Baker Angela , Koeman Julie , Barbacioru Catalin , Sakarya Onur , De La Vega Francisco M. , Siddiqui Asim , Hoang Linh , Billings Paul R. , Salhia Bodour , Tolcher Anthony W. , Trent Jeffrey M. , Mousses Spyro , Von Hoff Daniel , Carpten John D.
Published: April 2023

XLSX file - 61K, List of somatic point mutations in mTNBC detected by NGS sequencing analysis
Supplementary Table 6 from Genome and Transcriptome Sequencing in Prospective Metastatic Triple-Negative Breast Cancer Uncovers Therapeutic Vulnerabilities
Authors: Craig David W. , O'Shaughnessy Joyce A. , Kiefer Jeffrey A. , Aldrich Jessica , Sinari Shripad , Moses Tracy M. , Wong Shukmei , Dinh Jennifer , Christoforides Alexis , Blum Joanne L. , Aitelli Cristi L. , Osborne Cynthia R. , Izatt Tyler , Kurdoglu Ahmet , Baker Angela , Koeman Julie , Barbacioru Catalin , Sakarya Onur , De La Vega Francisco M. , Siddiqui Asim , Hoang Linh , Billings Paul R. , Salhia Bodour , Tolcher Anthony W. , Trent Jeffrey M. , Mousses Spyro , Von Hoff Daniel , Carpten John D.
Published: April 2023

XLSX file - 23K, Mapping statistics for genome sequencing of tumor and germline DNA from mTNBC
Supplementary Table 1 from Global Evaluation of Eph Receptors and Ephrins in Lung Adenocarcinomas Identifies EphA4 as an Inhibitor of Cell Migration and Invasion
Authors: Saintigny Pierre , Peng Shaohua , Zhang Li , Sen Banibrata , Wistuba Ignacio I. , Lippman Scott M. , Girard Luc , Minna John D. , Heymach John V. , Johnson Faye M.
Published: April 2023

PDF file, 50K, Sequences of Primers for PCR.
Supplementary Table 5 from Genome and Transcriptome Sequencing in Prospective Metastatic Triple-Negative Breast Cancer Uncovers Therapeutic Vulnerabilities
Authors: Craig David W. , O'Shaughnessy Joyce A. , Kiefer Jeffrey A. , Aldrich Jessica , Sinari Shripad , Moses Tracy M. , Wong Shukmei , Dinh Jennifer , Christoforides Alexis , Blum Joanne L. , Aitelli Cristi L. , Osborne Cynthia R. , Izatt Tyler , Kurdoglu Ahmet , Baker Angela , Koeman Julie , Barbacioru Catalin , Sakarya Onur , De La Vega Francisco M. , Siddiqui Asim , Hoang Linh , Billings Paul R. , Salhia Bodour , Tolcher Anthony W. , Trent Jeffrey M. , Mousses Spyro , Von Hoff Daniel , Carpten John D.
Published: April 2023

XLSX file - 607K, Outlier differential expression results in mTNBC for select cancer related genes
Supplementary Table 3 from Genome and Transcriptome Sequencing in Prospective Metastatic Triple-Negative Breast Cancer Uncovers Therapeutic Vulnerabilities
Authors: Craig David W. , O'Shaughnessy Joyce A. , Kiefer Jeffrey A. , Aldrich Jessica , Sinari Shripad , Moses Tracy M. , Wong Shukmei , Dinh Jennifer , Christoforides Alexis , Blum Joanne L. , Aitelli Cristi L. , Osborne Cynthia R. , Izatt Tyler , Kurdoglu Ahmet , Baker Angela , Koeman Julie , Barbacioru Catalin , Sakarya Onur , De La Vega Francisco M. , Siddiqui Asim , Hoang Linh , Billings Paul R. , Salhia Bodour , Tolcher Anthony W. , Trent Jeffrey M. , Mousses Spyro , Von Hoff Daniel , Carpten John D.
Published: April 2023

XLSX file - 598K, edgeR differential expression results in mTNBC for select cancer related genes
Supplementary Table 2 from Genome and Transcriptome Sequencing in Prospective Metastatic Triple-Negative Breast Cancer Uncovers Therapeutic Vulnerabilities
Authors: Craig David W. , O'Shaughnessy Joyce A. , Kiefer Jeffrey A. , Aldrich Jessica , Sinari Shripad , Moses Tracy M. , Wong Shukmei , Dinh Jennifer , Christoforides Alexis , Blum Joanne L. , Aitelli Cristi L. , Osborne Cynthia R. , Izatt Tyler , Kurdoglu Ahmet , Baker Angela , Koeman Julie , Barbacioru Catalin , Sakarya Onur , De La Vega Francisco M. , Siddiqui Asim , Hoang Linh , Billings Paul R. , Salhia Bodour , Tolcher Anthony W. , Trent Jeffrey M. , Mousses Spyro , Von Hoff Daniel , Carpten John D.
Published: April 2023

XLSX file - 48K, Transcriptome sequencing (RNA-seq) run statistics for mTNBC
Supplementary Figure 7 from Global Evaluation of Eph Receptors and Ephrins in Lung Adenocarcinomas Identifies EphA4 as an Inhibitor of Cell Migration and Invasion
Authors: Saintigny Pierre , Peng Shaohua , Zhang Li , Sen Banibrata , Wistuba Ignacio I. , Lippman Scott M. , Girard Luc , Minna John D. , Heymach John V. , Johnson Faye M.
Published: April 2023

PDF file, 39K, EPHA4 effect on other EPHs and EFNs.
Supplementary Figure 3 from Genome and Transcriptome Sequencing in Prospective Metastatic Triple-Negative Breast Cancer Uncovers Therapeutic Vulnerabilities
Authors: Craig David W. , O'Shaughnessy Joyce A. , Kiefer Jeffrey A. , Aldrich Jessica , Sinari Shripad , Moses Tracy M. , Wong Shukmei , Dinh Jennifer , Christoforides Alexis , Blum Joanne L. , Aitelli Cristi L. , Osborne Cynthia R. , Izatt Tyler , Kurdoglu Ahmet , Baker Angela , Koeman Julie , Barbacioru Catalin , Sakarya Onur , De La Vega Francisco M. , Siddiqui Asim , Hoang Linh , Billings Paul R. , Salhia Bodour , Tolcher Anthony W. , Trent Jeffrey M. , Mousses Spyro , Von Hoff Daniel , Carpten John D.
Published: April 2023

PDF file - 1635K, PET/CT images of mTNBC2 breast lesion before and after treatment on combination MEK and AKT inhibitors
Supplementary Figure 5 from Global Evaluation of Eph Receptors and Ephrins in Lung Adenocarcinomas Identifies EphA4 as an Inhibitor of Cell Migration and Invasion
Authors: Saintigny Pierre , Peng Shaohua , Zhang Li , Sen Banibrata , Wistuba Ignacio I. , Lippman Scott M. , Girard Luc , Minna John D. , Heymach John V. , Johnson Faye M.
Published: April 2023

PDF file, 105K, EPHA4, apoptosis and cell cycle.
Supplementary Figure 2 from Genome and Transcriptome Sequencing in Prospective Metastatic Triple-Negative Breast Cancer Uncovers Therapeutic Vulnerabilities
Authors: Craig David W. , O'Shaughnessy Joyce A. , Kiefer Jeffrey A. , Aldrich Jessica , Sinari Shripad , Moses Tracy M. , Wong Shukmei , Dinh Jennifer , Christoforides Alexis , Blum Joanne L. , Aitelli Cristi L. , Osborne Cynthia R. , Izatt Tyler , Kurdoglu Ahmet , Baker Angela , Koeman Julie , Barbacioru Catalin , Sakarya Onur , De La Vega Francisco M. , Siddiqui Asim , Hoang Linh , Billings Paul R. , Salhia Bodour , Tolcher Anthony W. , Trent Jeffrey M. , Mousses Spyro , Von Hoff Daniel , Carpten John D.
Published: April 2023

PDF file - 135K, Validation of RB1 39bp homozygous deletion in mTNBC1
Supplementary Figure 4 from Global Evaluation of Eph Receptors and Ephrins in Lung Adenocarcinomas Identifies EphA4 as an Inhibitor of Cell Migration and Invasion
Authors: Saintigny Pierre , Peng Shaohua , Zhang Li , Sen Banibrata , Wistuba Ignacio I. , Lippman Scott M. , Girard Luc , Minna John D. , Heymach John V. , Johnson Faye M.
Published: April 2023

PDF file, 48K, EFNA1, EFNB2, EPHB2 mRNA levels.
Supplementary Figure 1 from Genome and Transcriptome Sequencing in Prospective Metastatic Triple-Negative Breast Cancer Uncovers Therapeutic Vulnerabilities
Authors: Craig David W. , O'Shaughnessy Joyce A. , Kiefer Jeffrey A. , Aldrich Jessica , Sinari Shripad , Moses Tracy M. , Wong Shukmei , Dinh Jennifer , Christoforides Alexis , Blum Joanne L. , Aitelli Cristi L. , Osborne Cynthia R. , Izatt Tyler , Kurdoglu Ahmet , Baker Angela , Koeman Julie , Barbacioru Catalin , Sakarya Onur , De La Vega Francisco M. , Siddiqui Asim , Hoang Linh , Billings Paul R. , Salhia Bodour , Tolcher Anthony W. , Trent Jeffrey M. , Mousses Spyro , Von Hoff Daniel , Carpten John D.
Published: April 2023

PDF file - 72K, Profiles of germline/tumor single base mutations by genotype in mTNBC
Supplementary Figure 2 from Global Evaluation of Eph Receptors and Ephrins in Lung Adenocarcinomas Identifies EphA4 as an Inhibitor of Cell Migration and Invasion
Authors: Saintigny Pierre , Peng Shaohua , Zhang Li , Sen Banibrata , Wistuba Ignacio I. , Lippman Scott M. , Girard Luc , Minna John D. , Heymach John V. , Johnson Faye M.
Published: April 2023

PDF file, 37K, Ephs and eprins in vitro.
Supplementary Table 3 from A Novel Antiandrogen, Compound 30, Suppresses Castration-Resistant and MDV3100-Resistant Prostate Cancer Growth In Vitro and In Vivo
Authors: Kuruma Hidetoshi , Matsumoto Hiroaki , Shiota Masaki , Bishop Jennifer , Lamoureux Francois , Thomas Christian , Briere David , Los Gerrit , Gleave Martin , Fanjul Andrea , Zoubeidi Amina
Published: April 2023

PDF, 56K, MDV3100 IC50 in LNCaP and MR49F cells
Supplementary Table 5 from Pharmacogenomic Profiling and Pathway Analyses Identify MAPK-Dependent Migration as an Acute Response to SN38 in p53 Null and p53-Mutant Colorectal Cancer Cells
Authors: Allen Wendy L. , Turkington Richard C. , Stevenson Leanne , Carson Gail , Coyle Vicky M. , Hector Suzanne , Dunne Philip , Van Schaeybroeck Sandra , Longley Daniel B. , Johnston Patrick G.
Published: April 2023

PDF file - 11K, Real-time PCR validation of genes basally altered between HCT116 p53 null cells and HCT116 p53 wild-type cells. This table shows the p53 null fold change by microarray and the p53 null fold change by real-time PCR, all compared to the p53wild-type cell expression values
Supplementary Figure 2 from Restoration of miR-200c to Ovarian Cancer Reduces Tumor Burden and Increases Sensitivity to Paclitaxel
Authors: Cittelly Diana M. , Dimitrova Irina , Howe Erin N. , Cochrane Dawn R. , Jean Annie , Spoelstra Nicole S. , Post Miriam D. , Lu Xian , Broaddus Russell R. , Spillman Monique A. , Richer Jennifer K.
Published: April 2023

PDF file - 221K, Restoration of miR-200c to ovarian cancer cells reduces βIII-tubulin expression
Supplementary Figure 1 from Restoration of miR-200c to Ovarian Cancer Reduces Tumor Burden and Increases Sensitivity to Paclitaxel
Authors: Cittelly Diana M. , Dimitrova Irina , Howe Erin N. , Cochrane Dawn R. , Jean Annie , Spoelstra Nicole S. , Post Miriam D. , Lu Xian , Broaddus Russell R. , Spillman Monique A. , Richer Jennifer K.
Published: April 2023

PDF file - 1005K, Restoration of miR-200c results in decreased proliferation and decreased ZEB expression
Supplementary Figure Legends from Biological Characterization of TAK-901, an Investigational, Novel, Multitargeted Aurora B Kinase Inhibitor
Authors: Farrell Pamela , Shi Lihong , Matuszkiewicz Jennifer , Balakrishna Deepika , Hoshino Takashi , Zhang Lilly , Elliott Sarah , Fabrey Robyn , Lee Bumsup , Halkowycz Petro , Sang BiChing , Ishino Seigo , Nomura Toshiyuki , Teratani Mika , Ohta Yoshikazu , Grimshaw Charles , Paraselli Bheema , Satou Takashi , de Jong Ron
Published: April 2023

PDF file - 56 KB
Supplementary Figures 1-2, Table 1 from Retinoid-Regulated FGF8f Secretion by Osteoblasts Bypasses Retinoid Stimuli to Mediate Granulocytic Differentiation of Myeloid Leukemia Cells
Authors: Chaudhry Parvesh , Yang Xiaochun , Wagner Michael , Jong Ambrose , Wu Lingtao
Published: April 2023

PDF file - 125K
Supplementary Figure 1 from Biological Characterization of TAK-901, an Investigational, Novel, Multitargeted Aurora B Kinase Inhibitor
Authors: Farrell Pamela , Shi Lihong , Matuszkiewicz Jennifer , Balakrishna Deepika , Hoshino Takashi , Zhang Lilly , Elliott Sarah , Fabrey Robyn , Lee Bumsup , Halkowycz Petro , Sang BiChing , Ishino Seigo , Nomura Toshiyuki , Teratani Mika , Ohta Yoshikazu , Grimshaw Charles , Paraselli Bheema , Satou Takashi , de Jong Ron
Published: April 2023

PDF file - 3 MB, Quantitative cellular target profiling of TAK-901 using affinity chromatography.
Supplementary Figure Legend from Efficacy of Low-Dose Oral Metronomic Dosing of the Prodrug of Gemcitabine, LY2334737, in Human Tumor Xenografts
Authors: Pratt Susan E. , Durland–Busbice Sara , Shepard Robert L. , Donoho Gregory P. , Starling James J. , Wickremsinhe Enaksha R. , Perkins Everett J. , Dantzig Anne H.
Published: April 2023

PDF file - 72K
Supplementary Figure Legends 1-3 from The Thymidine Phosphorylase Inhibitor 5′-O-Tritylinosine (KIN59) Is an Antiangiogenic Multitarget Fibroblast Growth Factor-2 Antagonist
Authors: Liekens Sandra , Bronckaers Annelies , Belleri Mirella , Bugatti Antonella , Sienaert Rebecca , Ribatti Domenico , Nico Beatrice , Gigante Alba , Casanova Elena , Opdenakker Ghislain , Pérez-Pérez María-Jesús , Balzarini Jan , Presta Marco
Published: April 2023

PDF file - 109K
Supplementary Figure 2 from The Thymidine Phosphorylase Inhibitor 5′-O-Tritylinosine (KIN59) Is an Antiangiogenic Multitarget Fibroblast Growth Factor-2 Antagonist
Authors: Liekens Sandra , Bronckaers Annelies , Belleri Mirella , Bugatti Antonella , Sienaert Rebecca , Ribatti Domenico , Nico Beatrice , Gigante Alba , Casanova Elena , Opdenakker Ghislain , Pérez-Pérez María-Jesús , Balzarini Jan , Presta Marco
Published: April 2023

PDF file - 238K
Supplementary Figure 4 from UNC569, a Novel Small-Molecule Mer Inhibitor with Efficacy against Acute Lymphoblastic Leukemia In Vitro and In Vivo
Authors: Christoph Sandra , DeRyckere Deborah , Schlegel Jennifer , Frazer J. Kimble , Batchelor Lance A. , Trakhimets Alesia Y. , Sather Susan , Hunter Debra M. , Cummings Christopher T. , Liu Jing , Yang Chao , Kireev Dmitri , Simpson Catherine , Norris-Drouin Jacqueline , Hull-Ryde Emily A. , Janzen William P. , Johnson Gary L. , Wang Xiaodong , Frye Stephen V. , Earp H. Shelton , Graham Douglas K.
Published: April 2023

PDF - 358KB, Cells were plated in methylcellulose in the presence of the indicated concentrations of UNC1653 or vehicle only. Colonies were counted after eight days. Long-term colony growth of Jurkat cells in methylcellulose is shown. Mean values and standard errors were derived from 3 independent experiments.
Supplementary Figure 3 from UNC569, a Novel Small-Molecule Mer Inhibitor with Efficacy against Acute Lymphoblastic Leukemia In Vitro and In Vivo
Authors: Christoph Sandra , DeRyckere Deborah , Schlegel Jennifer , Frazer J. Kimble , Batchelor Lance A. , Trakhimets Alesia Y. , Sather Susan , Hunter Debra M. , Cummings Christopher T. , Liu Jing , Yang Chao , Kireev Dmitri , Simpson Catherine , Norris-Drouin Jacqueline , Hull-Ryde Emily A. , Janzen William P. , Johnson Gary L. , Wang Xiaodong , Frye Stephen V. , Earp H. Shelton , Graham Douglas K.
Published: April 2023

PDF - 164KB, Jurkat and 697 cell cultures were treated with UNC569 (500 nM) for 1 hour. Pervanadate was added to cell cultures for 3 minutes to stabilize the phosphorylated form of Mer. Cells were harvested after 24 and after 48 hours. Mer was immunoprecipitated from cell lysates and total Mer protein and Mer phosphoprotein (p-Mer) were detected by western blot.
Supplementary Figure Legends from Overcoming Platinum Resistance in Preclinical Models of Ovarian Cancer Using the Neddylation Inhibitor MLN4924
Authors: Jazaeri Amir A. , Shibata Etsuko , Park Jonghoon , Bryant Jennifer L. , Conaway Mark R. , Modesitt Susan C. , Smith Peter G. , Milhollen Michael A. , Berger Allison J. , Dutta Anindya
Published: April 2023

PDF file, 45K.
Supplementary Figure 1 from Overcoming Platinum Resistance in Preclinical Models of Ovarian Cancer Using the Neddylation Inhibitor MLN4924
Authors: Jazaeri Amir A. , Shibata Etsuko , Park Jonghoon , Bryant Jennifer L. , Conaway Mark R. , Modesitt Susan C. , Smith Peter G. , Milhollen Michael A. , Berger Allison J. , Dutta Anindya
Published: April 2023

PDF file, 340K, CDT1 levels in SKOV3 and ES2 cells.
Supplementary Table 3 from Impact of Intrinsic Affinity on Functional Binding and Biological Activity of EGFR Antibodies
Authors: Zhou Yu , Goenaga Anne-Laure , Harms Brian D. , Zou Hao , Lou Jianlong , Conrad Fraser , Adams Gregory P. , Schoeberl Birgit , Nielsen Ulrik B. , Marks James D.
Published: April 2023

PDF file, 52KB, Comparison of measured apparent IgG affinities vs affinities calculated by using a mathematical model on cells of different EGFR density (A431, MDAMB468, and MDAMB231).
Supplementary Data PDF file from Downregulation of HER3 by a Novel Antisense Oligonucleotide, EZN-3920, Improves the Antitumor Activity of EGFR and HER2 Tyrosine Kinase Inhibitors in Animal Models
Authors: Wu Yaming , Zhang Yixian , Wang Maoliang , Li Qi , Qu Zhengxing , Shi Victoria , Kraft Patricia , Kim Steve , Gao Ying , Pak Jenny , Youngster Stephen , Horak Ivan D. , Greenberger Lee M.
Published: April 2023

Supplementary Data PDF file - 600K, Table S1 shows the selection of the lead candidate EZN-3920 based on its specificity and potency in cells. Table S2 describes the potency of EZN-3920 in multiple cancer cell lines. Fig. S1 shows that specific inhibition of HER3 protein and its downstream signaling molecule, phospho-AKT results in cellular death of 15PC3 prostate cancer cells. Fig. S2. shows specific HER3 mRNA down-regulation by EZN-3920 in the absence of lipofection in 15PC3 prostate cancer cells. Fig. S3. shows potent down-regulation of HER3 in the liver of mice treated with EZN-3920 simply dissolved in saline. Fig. S4. shows that treatment of EZN-3920 is capable of blocking gefitinib induced up-regulation of HER3 in the HCC827 tumors. Fig. S5. Shows that cell lines resistant to gefitinib or transtuzumab remains sensitive to EZN-3920. Fig. S6. Shows that treatment EZN-3920 down-regulates HER3 as well as its down-stream signaling molecules in cancer cells
Supplementary Table 2 from Impact of Intrinsic Affinity on Functional Binding and Biological Activity of EGFR Antibodies
Authors: Zhou Yu , Goenaga Anne-Laure , Harms Brian D. , Zou Hao , Lou Jianlong , Conrad Fraser , Adams Gregory P. , Schoeberl Birgit , Nielsen Ulrik B. , Marks James D.
Published: April 2023

PDF file, 56KB, Kinetic parameters used in the computational model of antibody binding.
Supplementary Tables 1-3 from Analysis of DNA Repair–Related Genes in Breast Cancer Reveals CUL4A Ubiquitin Ligase as a Novel Biomarker of Trabectedin Response
Authors: García María J. , Saucedo-Cuevas Laura Paula , Muñoz-Repeto Iván , Fernández Victoria , Robles María J. , Domingo Samuel , Palacios José , Aracil Miguel , Nieto Antonio , Tercero Juan Carlos , Benítez Javier
Published: April 2023

PDF file - 117 KB, Supplementary Table 1: Immunohistopathological characteristics of primary breast tumours; Supplementary Table 2: Characteristics of sarcoma patients; Supplementary Table 3: Sequence of qRT-PCR primers and probes and shRNAs used for CUL4A silencing
Supplementary Figure Legend from Impact of Intrinsic Affinity on Functional Binding and Biological Activity of EGFR Antibodies
Authors: Zhou Yu , Goenaga Anne-Laure , Harms Brian D. , Zou Hao , Lou Jianlong , Conrad Fraser , Adams Gregory P. , Schoeberl Birgit , Nielsen Ulrik B. , Marks James D.
Published: April 2023

PDF file, 62KB.
Supplementary Figure 2 from Impact of Intrinsic Affinity on Functional Binding and Biological Activity of EGFR Antibodies
Authors: Zhou Yu , Goenaga Anne-Laure , Harms Brian D. , Zou Hao , Lou Jianlong , Conrad Fraser , Adams Gregory P. , Schoeberl Birgit , Nielsen Ulrik B. , Marks James D.
Published: April 2023

PDF file, 95KB, Comparison of cell-binding curves for low and high affinity anti-EGFR IgG antibodies at the experimental incubation time and a hypothetical time.
Supplementary Figure S2 from Analysis of DNA Repair–Related Genes in Breast Cancer Reveals CUL4A Ubiquitin Ligase as a Novel Biomarker of Trabectedin Response
Authors: García María J. , Saucedo-Cuevas Laura Paula , Muñoz-Repeto Iván , Fernández Victoria , Robles María J. , Domingo Samuel , Palacios José , Aracil Miguel , Nieto Antonio , Tercero Juan Carlos , Benítez Javier
Published: April 2023

PDF file - 6 MB, Trabectedin cell cycle effects
Supplemental Materials and Methods, Supplementary Tables 1 through 3, Supplementary Figures 1 through 4 from BAY 80-6946 Is a Highly Selective Intravenous PI3K Inhibitor with Potent p110α and p110δ Activities in Tumor Cell Lines and Xenograft Models
Authors: Liu Ningshu , Rowley Bruce R. , Bull Cathy O. , Schneider Claudia , Haegebarth Andrea , Schatz Christoph A. , Fracasso Paul R. , Wilkie Dean P. , Hentemann Martin , Wilhelm Scott M. , Scott William J. , Mumberg Dominik , Ziegelbauer Karl
Published: April 2023

Supplementary Materials and Methods. Supplemental Table S1. Combination effects of BAY 80-6946 and lapatinib on caspase 9 activation in BT474 cells. Supplemental Table S2. Single dose i.v. pharmacokinetic parameter of BAY 80-6946 in female nude rats and ICR mice (n=3 per timepoint). Supplemental Table S3. Combination effects of BAY 80-6946 and paclitaxel in patient-derived NSCLC xenograft tumor model. Supplemental Figure S1: Chemical structure of reference compounds. Supplemental Figure S2. Nuclear translocation of FOXO1A in U2OS cells. Supplemental Figure S3. Caspase 9 activity in BT474 and BT20 cells measured 24 hours after exposure to BAY 80-6946 and reference drugs. Supplemental Figure S4. Single and multiple dose i.v. plasma concentration versus time profile of BAY 80-6946 in female nude rats (n=2 per timepoint).
Supplementary Table 1 from The Association of PI3 Kinase Signaling and Chemoresistance in Advanced Ovarian Cancer
Authors: Carden Craig P. , Stewart Adam , Thavasu Parames , Kipps Emma , Pope Lorna , Crespo Mateus , Miranda Susana , Attard Gerhardt , Garrett Michelle D. , Clarke Paul A. , Workman Paul , de Bono Johann S. , Gore Martin , Kaye Stan B , Banerji Udai
Published: April 2023

PDF file, 66KB, Oncogenes and mutations detected using the OncoCarta Panel v1.0.
Supplementary Figure S2 from Pharmacologic Blockade of FAK Autophosphorylation Decreases Human Glioblastoma Tumor Growth and Synergizes with Temozolomide
Authors: Golubovskaya Vita M. , Huang Grace , Ho Baotran , Yemma Michael , Morrison Carl D. , Lee Jisook , Eliceiri Brian P. , Cance William G.
Published: April 2023

PDF file - 41KB, The combination of Y15 and temozolomide decreases more significantly viability of U251 cells than each agent alone.
Supplementary Figure Legend from The Association of PI3 Kinase Signaling and Chemoresistance in Advanced Ovarian Cancer
Authors: Carden Craig P. , Stewart Adam , Thavasu Parames , Kipps Emma , Pope Lorna , Crespo Mateus , Miranda Susana , Attard Gerhardt , Garrett Michelle D. , Clarke Paul A. , Workman Paul , de Bono Johann S. , Gore Martin , Kaye Stan B , Banerji Udai
Published: April 2023

PDF file, 63KB.
Supplementary Figure S1 from Pharmacologic Blockade of FAK Autophosphorylation Decreases Human Glioblastoma Tumor Growth and Synergizes with Temozolomide
Authors: Golubovskaya Vita M. , Huang Grace , Ho Baotran , Yemma Michael , Morrison Carl D. , Lee Jisook , Eliceiri Brian P. , Cance William G.
Published: April 2023

PDF file - 349KB, Enlarged immunostaining image of U87 cells show decrease and change of Y397-FAK and FAK localization in Y15-treated compared with untreated cells.
Supplementary Figure 2 from The Association of PI3 Kinase Signaling and Chemoresistance in Advanced Ovarian Cancer
Authors: Carden Craig P. , Stewart Adam , Thavasu Parames , Kipps Emma , Pope Lorna , Crespo Mateus , Miranda Susana , Attard Gerhardt , Garrett Michelle D. , Clarke Paul A. , Workman Paul , de Bono Johann S. , Gore Martin , Kaye Stan B , Banerji Udai
Published: April 2023

PDF file, 47KB, Reproducibility of immunomagnetic separation and ELISA.
Supplementary Figure 1 from The Association of PI3 Kinase Signaling and Chemoresistance in Advanced Ovarian Cancer
Authors: Carden Craig P. , Stewart Adam , Thavasu Parames , Kipps Emma , Pope Lorna , Crespo Mateus , Miranda Susana , Attard Gerhardt , Garrett Michelle D. , Clarke Paul A. , Workman Paul , de Bono Johann S. , Gore Martin , Kaye Stan B , Banerji Udai
Published: April 2023

PDF file, 71KB, Efficiency of immunomagnetic separation.
Supplementary Data from The Association of PI3 Kinase Signaling and Chemoresistance in Advanced Ovarian Cancer
Authors: Carden Craig P. , Stewart Adam , Thavasu Parames , Kipps Emma , Pope Lorna , Crespo Mateus , Miranda Susana , Attard Gerhardt , Garrett Michelle D. , Clarke Paul A. , Workman Paul , de Bono Johann S. , Gore Martin , Kaye Stan B , Banerji Udai
Published: April 2023

PDF file, 80KB, Experiments detailing the validation of immunomagnetic separation and ELISA.
Supplementary Figure 8 from Apigenin Sensitizes Colon Cancer Cells to Antitumor Activity of ABT-263
Authors: Shao Huanjie , Jing Kai , Mahmoud Esraa , Huang Haihong , Fang Xianjun , Yu Chunrong
Published: April 2023

PDF - 453KB, Supplementary Figure S8. Apigenin did not alter expression of most Bcl-2 family proteins.
Supplementary Tables 1 - 3 from STAT3 Inhibition Overcomes Temozolomide Resistance in Glioblastoma by Downregulating MGMT Expression
Authors: Kohsaka Shinji , Wang Lei , Yachi Kazuhiro , Mahabir Roshan , Narita Takuhito , Itoh Tamio , Tanino Mishie , Kimura Taichi , Nishihara Hiroshi , Tanaka Shinya
Published: April 2023

PDF file, 38KB.
Supplementary Figure Legend from STAT3 Inhibition Overcomes Temozolomide Resistance in Glioblastoma by Downregulating MGMT Expression
Authors: Kohsaka Shinji , Wang Lei , Yachi Kazuhiro , Mahabir Roshan , Narita Takuhito , Itoh Tamio , Tanino Mishie , Kimura Taichi , Nishihara Hiroshi , Tanaka Shinya
Published: April 2023

PDF file, 73KB.
Supplementary Figure 5 from Apigenin Sensitizes Colon Cancer Cells to Antitumor Activity of ABT-263
Authors: Shao Huanjie , Jing Kai , Mahmoud Esraa , Huang Haihong , Fang Xianjun , Yu Chunrong
Published: April 2023

PDF - 484KB, Supplementary Figure S5. Overexpression of exogenous Mcl-1 prevented cleavage of caspase 3 and PARP.
Supplementary Figure 4 from Apigenin Sensitizes Colon Cancer Cells to Antitumor Activity of ABT-263
Authors: Shao Huanjie , Jing Kai , Mahmoud Esraa , Huang Haihong , Fang Xianjun , Yu Chunrong
Published: April 2023

PDF - 233KB, Supplementary Figure S4. ABT-263 treatment resulted in upregulation of Mcl-1.
Supplementary Figure Legends from Afatinib Prolongs Survival Compared with Gefitinib in an Epidermal Growth Factor Receptor-Driven Lung Cancer Model
Authors: Ninomiya Takashi , Takigawa Nagio , Ichihara Eiki , Ochi Nobuaki , Murakami Toshi , Honda Yoshihiro , Kubo Toshio , Minami Daisuke , Kudo Kenichiro , Tanimoto Mitsune , Kiura Katsuyuki
Published: April 2023

PDF File - 75K, Figure Legends for Supplemntary Figures 1-4.
Supplementary Figure 3 from Apigenin Sensitizes Colon Cancer Cells to Antitumor Activity of ABT-263
Authors: Shao Huanjie , Jing Kai , Mahmoud Esraa , Huang Haihong , Fang Xianjun , Yu Chunrong
Published: April 2023

PDF - 186KB, Supplementary Figure S3. Colon cancer cell lines displayed variable basal levels of Mcl-1 protein.
Supplementary Figure 4 from Afatinib Prolongs Survival Compared with Gefitinib in an Epidermal Growth Factor Receptor-Driven Lung Cancer Model
Authors: Ninomiya Takashi , Takigawa Nagio , Ichihara Eiki , Ochi Nobuaki , Murakami Toshi , Honda Yoshihiro , Kubo Toshio , Minami Daisuke , Kudo Kenichiro , Tanimoto Mitsune , Kiura Katsuyuki
Published: April 2023

PDF File - 178K, Western blot analysis of the signal transduction pathway.
Supplementary Figure 3 from Afatinib Prolongs Survival Compared with Gefitinib in an Epidermal Growth Factor Receptor-Driven Lung Cancer Model
Authors: Ninomiya Takashi , Takigawa Nagio , Ichihara Eiki , Ochi Nobuaki , Murakami Toshi , Honda Yoshihiro , Kubo Toshio , Minami Daisuke , Kudo Kenichiro , Tanimoto Mitsune , Kiura Katsuyuki
Published: April 2023

PDF File - 106K, Growth curves of (A) RPC-9 and (B) H1975 xenograft tumors in mice receiving oral administration of 10 mg/kg/day afatinib or 10 mg/kg/day gefitinib 5 times per week or i.p. administration of 5 mg/kg bevacizumab twice a week.
Supplementary Figure 1 from Apigenin Sensitizes Colon Cancer Cells to Antitumor Activity of ABT-263
Authors: Shao Huanjie , Jing Kai , Mahmoud Esraa , Huang Haihong , Fang Xianjun , Yu Chunrong
Published: April 2023

PDF - 187KB, Supplementary Figure S1. Chemical structure of apigenin (A) and ABT-263 (B).
Supplementary Figure 1 from Afatinib Prolongs Survival Compared with Gefitinib in an Epidermal Growth Factor Receptor-Driven Lung Cancer Model
Authors: Ninomiya Takashi , Takigawa Nagio , Ichihara Eiki , Ochi Nobuaki , Murakami Toshi , Honda Yoshihiro , Kubo Toshio , Minami Daisuke , Kudo Kenichiro , Tanimoto Mitsune , Kiura Katsuyuki
Published: April 2023

PDF File - 178K, The lung, skin, liver and intestine of transgenic mice with Egfr exon 19 deletion mutation and EGFR exon 21 L858R point mutation after 4 weeks administration of vehicle or afatinib..
Supplementary Materials and Methods and Figure Legends from Novel Inhibitors of Cyclin-Dependent Kinases Combat Hepatocellular Carcinoma without Inducing Chemoresistance
Authors: Haider Christine , Grubinger Markus , Řezníčková Eva , Weiss Thomas S. , Rotheneder Hans , Miklos Walter , Berger Walter , Jorda Radek , Zatloukal Marek , Gucký Tomáš , Strnad Miroslav , Kryštof Vladimír , Mikulits Wolfgang
Published: April 2023

PDF file, 82K.
Supplementary Figures 1 through 3 from Paclitaxel–Hyaluronic NanoConjugates Prolong Overall Survival in a Preclinical Brain Metastases of Breast Cancer Model
Authors: Mittapalli Rajendar K. , Liu Xinli , Adkins Chris E. , Nounou Mohamed I. , Bohn Kaci A. , Terrell Tori B. , Qhattal Hussaini S. , Geldenhuys Werner J. , Palmieri Diane , Steeg Patricia S. , Smith Quentin R. , Lockman Paul R.
Published: April 2023

Supplementary Figure S1: NMR Spectra of HA-Paclitaxel. 1H-NMR spectrum of HA-paclitaxel. Specific groups of HA-paclitaxel are shown with arrows; Supplementary Figure S2: Representative bioluminescent images of animals 24 hrs after intracardiac injection of the 231Br cells; Supplementary Figure S3: Representative image demonstrating that bioluminescence correlates well with histological location and burden of metastatic lesions in brain.
Supplementary Figure Legend from Paclitaxel–Hyaluronic NanoConjugates Prolong Overall Survival in a Preclinical Brain Metastases of Breast Cancer Model
Authors: Mittapalli Rajendar K. , Liu Xinli , Adkins Chris E. , Nounou Mohamed I. , Bohn Kaci A. , Terrell Tori B. , Qhattal Hussaini S. , Geldenhuys Werner J. , Palmieri Diane , Steeg Patricia S. , Smith Quentin R. , Lockman Paul R.
Published: April 2023

Supplementary Figure Legends
Supplementary Figure Legend from Molecular Mechanisms Involved in the Synergistic Interaction of the EZH2 Inhibitor 3-Deazaneplanocin A with Gemcitabine in Pancreatic Cancer Cells
Authors: Avan Amir , Crea Francesco , Paolicchi Elisa , Funel Niccola , Galvani Elena , Marquez Victor E , Honeywell Richard J. , Danesi Romano , Peters Godefridus J. , Giovannetti Elisa
Published: April 2023

PDF file, 69KB.
Supplementary Figure 2 from Molecular Mechanisms Involved in the Synergistic Interaction of the EZH2 Inhibitor 3-Deazaneplanocin A with Gemcitabine in Pancreatic Cancer Cells
Authors: Avan Amir , Crea Francesco , Paolicchi Elisa , Funel Niccola , Galvani Elena , Marquez Victor E , Honeywell Richard J. , Danesi Romano , Peters Godefridus J. , Giovannetti Elisa
Published: April 2023

PDF file, 117KB, Protein expression of E-cadherin, as detected by immunocytochemistry.
Supplementary Table S1 from Antitumor Activity and Pharmacodynamic Biomarkers of a Novel and Orally Available Small-Molecule Antagonist of Inhibitor of Apoptosis Proteins
Authors: Sumi Hiroyuki , Yabuki Masato , Iwai Kenichi , Morimoto Megumi , Hibino Ryosuke , Inazuka Masakazu , Hashimoto Kentaro , Kosugi Yohei , Aoyama Kazunobu , Yamamoto Shunsuke , Yoshimatsu Mie , Yamasaki Hideki , Tozawa Ryuichi , Ishikawa Tomoyasu , Yoshida Sei
Published: April 2023

PDF file - 37KB, Pharmacokinetic parameters of T-3256336 in mice
Supplementary Information from Antitumor Activity and Pharmacodynamic Biomarkers of a Novel and Orally Available Small-Molecule Antagonist of Inhibitor of Apoptosis Proteins
Authors: Sumi Hiroyuki , Yabuki Masato , Iwai Kenichi , Morimoto Megumi , Hibino Ryosuke , Inazuka Masakazu , Hashimoto Kentaro , Kosugi Yohei , Aoyama Kazunobu , Yamamoto Shunsuke , Yoshimatsu Mie , Yamasaki Hideki , Tozawa Ryuichi , Ishikawa Tomoyasu , Yoshida Sei
Published: April 2023

PDF file - 55KB
Supplementary Figures 1-4 from Sunitinib and SU11652 Inhibit Acid Sphingomyelinase, Destabilize Lysosomes, and Inhibit Multidrug Resistance
Authors: Ellegaard Anne-Marie , Groth-Pedersen Line , Oorschot Viola , Klumperman Judith , Kirkegaard Thomas , Nylandsted Jesper , Jäättelä Marja
Published: April 2023

PDF - 207KB, Supplementary Figure S1: Screen for small molecules that exhibit non-apoptotic cytotoxicity. Supplementary Figure S2: Kinetics of SU11652- and sunitinib-induced cytotoxicity. Supplementary Figure S3: SU11652 and sunitinib accumulate rapidly in lysosomes of MCF7 cells. Supplementary Figure S4: SU11652 does not alter the ultrastructure of mitochondria or ER.
Supplementary Figure S8 from Antitumor Activity and Pharmacodynamic Biomarkers of a Novel and Orally Available Small-Molecule Antagonist of Inhibitor of Apoptosis Proteins
Authors: Sumi Hiroyuki , Yabuki Masato , Iwai Kenichi , Morimoto Megumi , Hibino Ryosuke , Inazuka Masakazu , Hashimoto Kentaro , Kosugi Yohei , Aoyama Kazunobu , Yamamoto Shunsuke , Yoshimatsu Mie , Yamasaki Hideki , Tozawa Ryuichi , Ishikawa Tomoyasu , Yoshida Sei
Published: April 2023

PDF file - 97KB, Pharmacodynamics and antitumor activity analysis for T-3256336 in mice bearing MDA-MB-231-Luc cancer cells
Supplementary Figure S7 from Antitumor Activity and Pharmacodynamic Biomarkers of a Novel and Orally Available Small-Molecule Antagonist of Inhibitor of Apoptosis Proteins
Authors: Sumi Hiroyuki , Yabuki Masato , Iwai Kenichi , Morimoto Megumi , Hibino Ryosuke , Inazuka Masakazu , Hashimoto Kentaro , Kosugi Yohei , Aoyama Kazunobu , Yamamoto Shunsuke , Yoshimatsu Mie , Yamasaki Hideki , Tozawa Ryuichi , Ishikawa Tomoyasu , Yoshida Sei
Published: April 2023

PDF file - 433KB, Histopathological findings of organs on xenograft model
Supplementary Data 1 from CEP-32496: A Novel Orally Active BRAFV600E Inhibitor with Selective Cellular and In Vivo Antitumor Activity
Authors: James Joyce , Ruggeri Bruce , Armstrong Robert C. , Rowbottom Martin W. , Jones-Bolin Susan , Gunawardane Ruwanthi N. , Dobrzanski Pawel , Gardner Michael F. , Zhao Hugh , Cramer Merryl D. , Hunter Kathryn , Nepomuceno Ronald R. , Cheng Mangeng , Gitnick Dana , Yazdanian Mehran , Insko Darren E. , Ator Mark A. , Apuy Julius L. , Faraoni Raffaella , Dorsey Bruce D. , Williams Michael , Bhagwat Shripad S. , Holladay Mark W.
Published: April 2023

PDF file - 74K, CEP-32496 Supplemental Data.
Supplementary Figure S5 from Antitumor Activity and Pharmacodynamic Biomarkers of a Novel and Orally Available Small-Molecule Antagonist of Inhibitor of Apoptosis Proteins
Authors: Sumi Hiroyuki , Yabuki Masato , Iwai Kenichi , Morimoto Megumi , Hibino Ryosuke , Inazuka Masakazu , Hashimoto Kentaro , Kosugi Yohei , Aoyama Kazunobu , Yamamoto Shunsuke , Yoshimatsu Mie , Yamasaki Hideki , Tozawa Ryuichi , Ishikawa Tomoyasu , Yoshida Sei
Published: April 2023

PDF file - 274KB, Administration of T-3256336 induced reduction of tumor cIAP1 protein
Supplementary Figure S4 from Antitumor Activity and Pharmacodynamic Biomarkers of a Novel and Orally Available Small-Molecule Antagonist of Inhibitor of Apoptosis Proteins
Authors: Sumi Hiroyuki , Yabuki Masato , Iwai Kenichi , Morimoto Megumi , Hibino Ryosuke , Inazuka Masakazu , Hashimoto Kentaro , Kosugi Yohei , Aoyama Kazunobu , Yamamoto Shunsuke , Yoshimatsu Mie , Yamasaki Hideki , Tozawa Ryuichi , Ishikawa Tomoyasu , Yoshida Sei
Published: April 2023

PDF file - 57KB, Growth inhibition potency of T-3256336 on several cell lines
Supplementary Figure S3 from Antitumor Activity and Pharmacodynamic Biomarkers of a Novel and Orally Available Small-Molecule Antagonist of Inhibitor of Apoptosis Proteins
Authors: Sumi Hiroyuki , Yabuki Masato , Iwai Kenichi , Morimoto Megumi , Hibino Ryosuke , Inazuka Masakazu , Hashimoto Kentaro , Kosugi Yohei , Aoyama Kazunobu , Yamamoto Shunsuke , Yoshimatsu Mie , Yamasaki Hideki , Tozawa Ryuichi , Ishikawa Tomoyasu , Yoshida Sei
Published: April 2023

PDF file - 61KB, T-3256336 induced TNF-� dependent apoptosis in MDA-MB-231 cancer cells
Supplementary Figure 1 from Sym004, a Novel Anti-EGFR Antibody Mixture, Augments Radiation Response in Human Lung and Head and Neck Cancers
Authors: Huang Shyhmin , Peet Chimera R. , Saker Jarob , Li Chunrong , Armstrong Eric A. , Kragh Michael , Pedersen Mikkel W. , Harari Paul M.
Published: April 2023

PDF - 189KB, Comparison between Sym004 and cetuximab on radiosensitivity response.
Supplementary Table 1 from TRAIL Signaling and Synergy Mechanisms Used in TRAIL-Based Combination Therapies
Authors: Hellwig Christian T. , Rehm Markus
Published: April 2023

PDF file - 54K
Supplementary Figure 1 from New Use for an Old Drug: Inhibiting ABCG2 with Sorafenib
Authors: Wei Yinxiang , Ma Yuanfang , Zhao Qing , Ren Zhiguang , Li Yan , Hou Tingjun , Peng Hui
Published: April 2023

PDF file, 106KB, Effect of sorafenib on the intracellular mitoxantrone accumulation in the MCF7/MX cells.
Supplementary Table 2 from Transient Exposure to Quizartinib Mediates Sustained Inhibition of FLT3 Signaling while Specifically Inducing Apoptosis in FLT3-Activated Leukemia Cells
Authors: Gunawardane Ruwanthi N. , Nepomuceno Ronald R. , Rooks Allison M. , Hunt Jeremy P. , Ricono Jill M. , Belli Barbara , Armstrong Robert C.
Published: April 2023

PDF file - 42K, Quizartinib inhibition of MV4-11 tumor grwoth in vivo
Supplementary Figure 4 from Transient Exposure to Quizartinib Mediates Sustained Inhibition of FLT3 Signaling while Specifically Inducing Apoptosis in FLT3-Activated Leukemia Cells
Authors: Gunawardane Ruwanthi N. , Nepomuceno Ronald R. , Rooks Allison M. , Hunt Jeremy P. , Ricono Jill M. , Belli Barbara , Armstrong Robert C.
Published: April 2023

PDF file - 116K, Elevation of pro-apoptotic BimEL mirrors loss of anti-apoptotic Mcl-1
Supplementary Tables 1-2 from Chemotherapy Counteracts Metastatic Dissemination Induced by Antiangiogenic Treatment in Mice
Authors: Rovida Alessandra , Castiglioni Vittoria , Decio Alessandra , Scarlato Valentina , Scanziani Eugenio , Giavazzi Raffaella , Cesca Marta
Published: April 2023

PDF - 35K, Table 1: The effect of sunitinib combined with different chemotherapeutic agents on LLC primary tumors and metastasis; Supplementary Table 2: The effect of metronomic topotecan alone or combined with sunitinib on LLC primary tumor and metastasis.
Supplementary Figure 3 from Transient Exposure to Quizartinib Mediates Sustained Inhibition of FLT3 Signaling while Specifically Inducing Apoptosis in FLT3-Activated Leukemia Cells
Authors: Gunawardane Ruwanthi N. , Nepomuceno Ronald R. , Rooks Allison M. , Hunt Jeremy P. , Ricono Jill M. , Belli Barbara , Armstrong Robert C.
Published: April 2023

PDF file - 46K, Durability of quizartinib inhibition translates to loss of viability after brief exposure
Supplementary Figure 2 from Chemotherapy Counteracts Metastatic Dissemination Induced by Antiangiogenic Treatment in Mice
Authors: Rovida Alessandra , Castiglioni Vittoria , Decio Alessandra , Scarlato Valentina , Scanziani Eugenio , Giavazzi Raffaella , Cesca Marta
Published: April 2023

PDF - PDF 154K, Effect of sunitinib and sorafenib on metastatic Lewis Lung carcinoma.
Supplementary Figure 1 from Transient Exposure to Quizartinib Mediates Sustained Inhibition of FLT3 Signaling while Specifically Inducing Apoptosis in FLT3-Activated Leukemia Cells
Authors: Gunawardane Ruwanthi N. , Nepomuceno Ronald R. , Rooks Allison M. , Hunt Jeremy P. , Ricono Jill M. , Belli Barbara , Armstrong Robert C.
Published: April 2023

PDF file - 279K, Immunoblots of MV4-11, MOLM14, and SEM-K2 with quizartinib DR
Supplementary Figure Legends from [18F]-FLT Positron Emission Tomography Can Be Used to Image the Response of Sensitive Tumors to PI3-Kinase Inhibition with the Novel Agent GDC-0941
Authors: Cawthorne Christopher , Burrows Natalie , Gieling Roben G. , Morrow Christopher J. , Forster Duncan , Gregory Jamil , Radigois Marc , Smigova Alison , Babur Muhammad , Simpson Kathryn , Hodgkinson Cassandra , Brown Gavin , McMahon Adam , Dive Caroline , Hiscock Duncan , Wilson Ian , Williams Kaye J.
Published: April 2023

PDF file - 51 KB
Supplementary Figure 4 from Perillyl Alcohol for the Treatment of Temozolomide-Resistant Gliomas
Authors: Cho Hee-Yeon , Wang Weijun , Jhaveri Niyati , Torres Shering , Tseng Joshua , Leong Michelle N. , Lee David Jungpa , Goldkorn Amir , Xu Tong , Petasis Nicos A. , Louie Stan G. , Schönthal Axel H. , Hofman Florence M. , Chen Thomas C.
Published: April 2023

PDF file, 55K, Classical apoptosis pathways.
Supplementary Figure 3 from Perillyl Alcohol for the Treatment of Temozolomide-Resistant Gliomas
Authors: Cho Hee-Yeon , Wang Weijun , Jhaveri Niyati , Torres Shering , Tseng Joshua , Leong Michelle N. , Lee David Jungpa , Goldkorn Amir , Xu Tong , Petasis Nicos A. , Louie Stan G. , Schönthal Axel H. , Hofman Florence M. , Chen Thomas C.
Published: April 2023

PDF file, 38K, POH does not affect microvessel density.
Supplementary Figure 4 from [18F]-FLT Positron Emission Tomography Can Be Used to Image the Response of Sensitive Tumors to PI3-Kinase Inhibition with the Novel Agent GDC-0941
Authors: Cawthorne Christopher , Burrows Natalie , Gieling Roben G. , Morrow Christopher J. , Forster Duncan , Gregory Jamil , Radigois Marc , Smigova Alison , Babur Muhammad , Simpson Kathryn , Hodgkinson Cassandra , Brown Gavin , McMahon Adam , Dive Caroline , Hiscock Duncan , Wilson Ian , Williams Kaye J.
Published: April 2023

PDF file - 46 KB, Chronic dosing with GDC-0941 leads to an increase in MAP-kinase pathway signaling in sensitive tumors.
Supplementary Figure 2 from Perillyl Alcohol for the Treatment of Temozolomide-Resistant Gliomas
Authors: Cho Hee-Yeon , Wang Weijun , Jhaveri Niyati , Torres Shering , Tseng Joshua , Leong Michelle N. , Lee David Jungpa , Goldkorn Amir , Xu Tong , Petasis Nicos A. , Louie Stan G. , Schönthal Axel H. , Hofman Florence M. , Chen Thomas C.
Published: April 2023

PDF file, 55K, Lack of POH cytotoxicity in normal cells.
Supplementary Figure 3 from [18F]-FLT Positron Emission Tomography Can Be Used to Image the Response of Sensitive Tumors to PI3-Kinase Inhibition with the Novel Agent GDC-0941
Authors: Cawthorne Christopher , Burrows Natalie , Gieling Roben G. , Morrow Christopher J. , Forster Duncan , Gregory Jamil , Radigois Marc , Smigova Alison , Babur Muhammad , Simpson Kathryn , Hodgkinson Cassandra , Brown Gavin , McMahon Adam , Dive Caroline , Hiscock Duncan , Wilson Ian , Williams Kaye J.
Published: April 2023

PDF file - 75 KB, Uptake of 18F-FDG decreases significantly after ~18h of GDC-0941 treatment in U87, but not HCT116, tumors.
Supplementary Figure 1 from Perillyl Alcohol for the Treatment of Temozolomide-Resistant Gliomas
Authors: Cho Hee-Yeon , Wang Weijun , Jhaveri Niyati , Torres Shering , Tseng Joshua , Leong Michelle N. , Lee David Jungpa , Goldkorn Amir , Xu Tong , Petasis Nicos A. , Louie Stan G. , Schönthal Axel H. , Hofman Florence M. , Chen Thomas C.
Published: April 2023

PDF file, 45K, MGMT protein expressions in the different cell lines used in this study.
Supplementary Figure 2 from [18F]-FLT Positron Emission Tomography Can Be Used to Image the Response of Sensitive Tumors to PI3-Kinase Inhibition with the Novel Agent GDC-0941
Authors: Cawthorne Christopher , Burrows Natalie , Gieling Roben G. , Morrow Christopher J. , Forster Duncan , Gregory Jamil , Radigois Marc , Smigova Alison , Babur Muhammad , Simpson Kathryn , Hodgkinson Cassandra , Brown Gavin , McMahon Adam , Dive Caroline , Hiscock Duncan , Wilson Ian , Williams Kaye J.
Published: April 2023

PDF file - 65 KB, Acute dosing with GDC-0941 leads to an increase in apoptotic signaling in in sensitive tumors.
Supplementary Table 1 from In Vitro and In Vivo Therapeutic Efficacy of Carfilzomib in Mantle Cell Lymphoma: Targeting the Immunoproteasome
Authors: Zhang Liang , Pham Lan V. , Newberry Kate J. , Ou Zhishuo , Liang Rong , Qian Jianfei , Sun Luhong , Blonska Marzenna , You Yun , Yang Jing , Lin Xin , Rollo Alex , Tamayo Archito T. , Lee John , Ford Richard J. , Zhao Xiurong , Kwak Larry W. , Yi Qing , Wang Michael
Published: April 2023

Eight MCL Cell lines were cultured for 48 hours in the presence of different concentrations of CFZ. Cell growth was assessed by 3H-thymidine incorporation assay. The IC50 were determined by constructing a dose-response curve. Averages from 3 independent experiments are shown.
Supplementary Figure 1 from In Vitro and In Vivo Therapeutic Efficacy of Carfilzomib in Mantle Cell Lymphoma: Targeting the Immunoproteasome
Authors: Zhang Liang , Pham Lan V. , Newberry Kate J. , Ou Zhishuo , Liang Rong , Qian Jianfei , Sun Luhong , Blonska Marzenna , You Yun , Yang Jing , Lin Xin , Rollo Alex , Tamayo Archito T. , Lee John , Ford Richard J. , Zhao Xiurong , Kwak Larry W. , Yi Qing , Wang Michael
Published: April 2023

PDF - 1267KB, The established MCL cell lines, JVM-2, JVM-13, MAVER, NCEB-1, and Z-138 were treated with 20 nM CFZ for 0, 6, 12, or 24 hours and apoptosis was detected by Annexin V-binding assays. Representative histograms (left panel) and percentages of apoptotic cells (right panel) are shown.
Supplementary Methods and Figure Legend from Activation of IL-6R/JAK1/STAT3 Signaling Induces De Novo Resistance to Irreversible EGFR Inhibitors in Non–Small Cell Lung Cancer with T790M Resistance Mutation
Authors: Kim Sun Mi , Kwon Oh-Joon , Hong Yun Kyoung , Kim Joo Hang , Solca Flavio , Ha Sang-Jun , Soo Ross A. , Christensen James G. , Lee Ji Hyun , Cho Byoung Chul
Published: April 2023

PDF file, 92K.
Supplementary Figure 2 from The CXCR2 Antagonist, SCH-527123, Shows Antitumor Activity and Sensitizes Cells to Oxaliplatin in Preclinical Colon Cancer Models
Authors: Ning Yan , Labonte Melissa J. , Zhang Wu , Bohanes Pierre O. , Gerger Armin , Yang Dongyun , Benhaim Leonor , Paez David , Rosenberg David O. , Nagulapalli Venkata Kalyan C. , Louie Stan G. , Petasis Nicos A. , Ladner Robert D. , Lenz Heinz-Josef
Published: April 2023

PDF file, 5.9MB, Clonogenicity assay.
Supplementary Figure 7 from Activation of IL-6R/JAK1/STAT3 Signaling Induces De Novo Resistance to Irreversible EGFR Inhibitors in Non–Small Cell Lung Cancer with T790M Resistance Mutation
Authors: Kim Sun Mi , Kwon Oh-Joon , Hong Yun Kyoung , Kim Joo Hang , Solca Flavio , Ha Sang-Jun , Soo Ross A. , Christensen James G. , Lee Ji Hyun , Cho Byoung Chul
Published: April 2023

PDF file, 53K, Anti-proliferative effect of dacomitinib in NSCLC cells harboring EGFR T790M.
Supplementary Figure Legend from HDAC Inhibitor Entinostat Restores Responsiveness of Letrozole-Resistant MCF-7Ca Xenografts to Aromatase Inhibitors through Modulation of Her-2
Authors: Sabnis Gauri J. , Goloubeva Olga G. , Kazi Armina A. , Shah Preeti , Brodie Angela H.
Published: April 2023

PDF file - 61K
Supplementary Figure 1 from CRM1 and BRAF Inhibition Synergize and Induce Tumor Regression in BRAF-Mutant Melanoma
Authors: Salas Fragomeni Roberto A. , Chung Hye Won , Landesman Yosef , Senapedis William , Saint-Martin Jean-Richard , Tsao Hensin , Flaherty Keith T. , Shacham Sharon , Kauffman Michael , Cusack James C.
Published: April 2023

Supplementary Figure 1 - PDF file 29K, CRM1 and BRAF inhibition decrease melanoma cell proliferation and are synergistic in vitro
Supplementary Figure 2 from Differential Antitumor Activity of Aflibercept and Bevacizumab in Patient-Derived Xenograft Models of Colorectal Cancer
Authors: Chiron Marielle , Bagley Rebecca G. , Pollard Jack , Mankoo Parminder K. , Henry Christophe , Vincent Loïc , Geslin Catherine , Baltes Nina , Bergstrom Donald A.
Published: April 2023

PDF - 6591K, Tumor growth curves utilizing median ATVs of the 48 CRC PDXs: Tumor growth curves for all 48 patient-derived CRC tumors in mice engrafted SC, and which were treated with aflibercept SC injection (2x/week, 25 mg/kg), vehicle (SC injection, 2x/week), or bevacizumab (IV injection, 2x/week, 25 mg/kg) for a total of 3 weeks. Tumor measurements were recorded twice per week. Error bars represent MAD.
Supplementary Figure 1 from Differential Antitumor Activity of Aflibercept and Bevacizumab in Patient-Derived Xenograft Models of Colorectal Cancer
Authors: Chiron Marielle , Bagley Rebecca G. , Pollard Jack , Mankoo Parminder K. , Henry Christophe , Vincent Loïc , Geslin Catherine , Baltes Nina , Bergstrom Donald A.
Published: April 2023

PDF - 107K, Genomic characterization of PDX models: 48 PDX tumors comprising similar mutational patterns of KRAS, BRAF, PIK3CA, and PTEN have been reported in several other publications.