bluuebunny/crossref_metadata_2025 huggingface dataset:
World War II Art Restitution Exhibitions
Authors: Smith Claire Elizabeth
Published: September 2022

Art history is about more than just the works of art that are currently on display in art galleries and museums. It is also about all the works that have been lost, stolen, or destroyed due to tumultuous chapters in human history. One of the largest chapters in human history to affect art history were the events of World War II. In order to help heal the wounds caused by this war, art historians and museum professionals across Europe and North America have dedicated their time to provenance research in order to begin processes of restitution. Two museums that have allocated time and money for provenance research and art restitution are the Nelson-Atkins Museum of Art in Kansas City, Missouri, USA, and the Victoria and Albert Museum in London, England. This paper will examine these two museums and the exhibitions that resulted from their provenance research, as well as their restitution and repatriation work. By exploring the efforts made by the Nelson-Atkins Museum of Art and the Victoria and Albert Museum, one is given a glimpse into how art historians and museum professionals can help make amends with those affected by tragedy.
Perancangan aplikasi administrasi desa berbasis website menggunakan metode Booyer Moore
Authors: Ritonga Andimas , Nasution Khairuddin , Siambaton Mhd. Zulfansyuri
Published: September 2022

Aplikasi administrasi desa merupakan salah satu aplikasi yang penting bagi masyarakat dan perangkat desa Bagan Batu. Sehingga masyarakat dapat  mengetahui informasi tentang desa, struktur organisasi desa, apa saja kegiatan-kegiatan perangkat desa, berapa jumlah seluruh penduduk desa dan lainnya. Dan juga dapat mempermudah perangkat desa dalam mengolah data kependudukan dan data surat menyurat di desa Bagan Batu. Proses pencarian dalam suatu aplikasi administrasi desa sangatlah penting, namun terkadang proses pencarian itu lambat. Untuk mempercepat dan mempermudah suatu proses pencarian, dibutuhkan suatu algoritma yang dapat memaksimalkan proses pencarian tersebut. Algoritma pencarian yang dianggap memiliki hasil paling baik dalam praktiknya, yaitu algoritma yang bergerak mencocokkan string dari arah kanan ke kiri. Algoritma Boyer-Moore merupakan salah satu contoh algoritma yang menggunakan arah dari kanan ke kiri. Algoritma Boyer-Moore terbukti berhasil mempercepat pencarian data kependudukan sehingga membuat aplikasi terasa lebih ringan dan efisien
Perancangan Aplikasi Kamus Digital Bahasa Minang dengan Menggunakan Metode String Matching Knuth Morris Praat
Authors: Dhaneswara Nirwan Qadar , Nasution Khairuddin , Haramaini Tasliyah
Published: September 2022

Bahasa daerah merupakan salah satu bahasa dari keanekaragaman bangsa Indonesia termasuk bahasa minang. Untuk itu diperlukan sebuah Aplikasi Kamus Bahasa Minang khususnya dalam hal menterjemah kata dari bahasa Indonesia kedalam bahasa minang. Program aplikasi ini dibuat dan dikembangkan dengan perangkat lunak PHP, dengan adanya Program aplikasi kamus bahasa minang ini dapat lebih mudah dalam proses mencari kosa kata dari bahasa Indonesia ke bahasa minang. Sehingga pengguna akan dapat menghemat biaya dan waktu, hasil dari perancangan aplikasi ini diharapkan dapat membantu pengguna dalam memahami bahasa minang.
Analisis Perancangan Antena Mikrostrip Biquad Double Layer Untuk Aplikasi Wlan
Authors: Silaban Fernanda A. D.
Published: September 2022

Pada penelitian ini dirancang sebuah antena mikrostrip bicuad double layer untuk aplikasi wlan, dimana nilai VSWR yang didapat pada frekuensi 2,4 GHz sebesar 1,06, return loss, gain masing-masing -30,62 dB dan 5,82 dB dengan pola pancaran radiasi unidirectional. Ppercoban ini dilakukan diatas gedung untuk mendapatkan koneksi keseluruh ruangan gedung. Pada umumnya antena untuk aplikasi wlan memiliki pola pancaran pola radiasi omnidirectional yaitu antena dengan pola pancaran kesegala arah sama kuat, namun dianggap kurang efisien, karena mengalami rugi-rugi jika ada bangunan bertingkat tinggi.
PERENCANAAN PERSEDIAAN DARAH DENGAN METODE CONTIUOUS REVIEW SISTEM PADA PALANG MERAH INDONESIA
Authors: Ridwan Muh , Gunawan Gunawan , Andriani Wresti
Published: September 2022

UTD PMI Kabupaten Tegal merupakan Beberapa Bank Darah Rumah Sakit (BDRS) di Kabupaten Tegal dan sekitarnya mengandalkan sumber darah ini. Karena banyaknya permintaan darah, ada kalanya tidak tersedia cukup darah, dan di sisi lain, PMI sudah berusaha semaksimal mungkin agar masyarakat tergerak kesadaran untuk berdonor darah agar stok selalu ready. Stok aman dan tanggal pemesanan darah berikutnya agar dapat ditentukan untuk mengatasi masalah kekurangan stock. Jumlah permintaan produk darah sel darah merah dalam kurun waktu 2021 yang dikumpulkan dari database PMI dan digunakan dalam analisis ini. Dalam penelitian ini digunakan metode Continuous Review System untuk mengevaluasi dan menentukan stok yang ideal guna mencegah jumlah darah yang rusak dan dapat diketahui persediaan masing-masing golongan darah. Selain itu sekaligus menurunkan biaya persediaan. Analisa yang dipakai menggunakan service level 100% sehingga diketahui savety stok, nilai ROP, Persediaan PRC Optimal dan Persediaan Maksimum PRC dan dapat mengurangi biaya sebesar 64% atau meminimalkan aliran darah keluar biaya operasional Selain itu agar masyarakat juga tahu akan pentingnya kebutuhan darah bagi pasien yang membutuhkan untuk transfusi, Temuan studi mengarah pada pasokan terbaik stok darah.
Analisis Sentimen Pelanggan Tokopedia Menggunakan Metode Naïve Bayes Classifier
Authors: Salsabila Sifa Melina , Alim Murtopo Aang , Fadhilah Nurul
Published: September 2022

Tokopedia adalah e-commerce dengan  pengunjung situs web terbanyak, mencapai 157 juta kunjungan pada kuartal pertama tahun 2022. Meskipun menempati urutan pertama dan bintang 5 menerima nilai paling banyak, itu pasti ada yang memberikan komentar negatif. Untuk membuktikan analisis dan pengujian itu maka memerlukan metode analisis dan klasifikasi komentar pelanggan dalam beberapa sentimen positif dan negatif. Analisis ini menggunakan metode Naïve Bayes Classifier terhadap komentar pelanggan tentang aplikasi Tokopedia di Playstore. Performa yang dihasilkan dari hasil percobaan yang dilakukan oleh rapid evaluator pada 143 data pengujian menghasilkan nilai akurasi 95,10%, dengan class recall: 91,46% (positive class: Positive) sedangkan class precision: 100.00% (positive class: Positive) dan nilai AUC: 0.999 (positive class: Positive)
SISTEM INFORMASI PELAYANAN PADA RUMAH SAKIT UMUM DAERAH SERUI
Authors: Maslihatin Tatik , Rahim Wisda , Rahmawati Nurul , Arafah Muhammad , Markani Markani
Published: September 2022

Rumah sakit merupakan tempat yang penting dalam melakukan pemeriksaan kesehatan. Sistem informasi rumah sakit dibutuhkan untuk memberikan pelayanan prima pada masyarakat. Saat ini system pada rumah sakit umum daerah Serui masih manual baik konsultasi ke dokter maupun pencarian pasien rawat inap. Hal ini membuat pasien dan pengunjung membutuhkan waktu sehingga menjadi tidak efektif.  Penelitian ini bertujuan untuk membuat system informasi yang memudahkan pengguna dalam mencari jadwal konsultasi dan mencari pasien rawat inap. Penelitian ini menghasilkan suatu system informasi pelayanan rumah sakit berbasis android. Berdasarkan pengujian terhadap tingkat kepuasan pengguna menghasilkan sebesar 81,59% responden menyatakan system informasi pelayanan rumah sakit umum daerah Serui layak untuk digunakan.
Методичний підхід до оцінювання стану функціонування національної економіки за показником розрахунку середньодобової вартості російсько-української війни
Authors: Semenenko Oleh , Chernyshova Iryna , Taran Olha , Motrunych Ivan , Onofriichuk Petro , Hetman Alevtyna
Published: September 2022

Мета роботи: розкриття суті методики розрахунку середньодобової вартості російсько-української війни.

Дизайн/Метод: основними методами досліджень є методи статистичного аналізу, воєнно-економічного аналізу, експертного опитування та методи прогнозування.

Результати дослідження: методика розрахунку середньодобової вартості російсько-української війни.

Теоретична цінність дослідження: основними результатами  досліджень за тематикою статті є методики розрахунку середньодобової вартості російсько-української війни.

Тип статті: т описовий та розрахунково-аналітичний.
Fake news e a desinformação sobre COVID-19: revisão integrativa de literatura
Authors: Santos Regina Consolação dos , Oliveira Simone Lopes , Resende Eloisa Ribeiro dos Santos , Nunes Tamires Cristina Alves , Tavares Thaís Barreiros , Cavalcante Ricardo Bezerra , Prado Amanda Cristina Teixeira do , Pena Heber Paulino
Published: September 2022

Objetivo: identificar na literatura disponível como as notícias falsas disseminadas durante a pandemia por COVID-19 podem levar ao desenvolvimento de sentimentos negativos, como medo, incerteza e preocupação. Métodos: trata-se uma revisão integrativa da literatura, em que para a elaboração da questão norteadora do estudo utilizou-se o acrômio PECO. Para o levantamento dos dados utilizou-se a PubMed, BVS e Scielo, junto aos Descritores em Ciências da Saúde (DeCS), combinados por meio do operador booleano AND. Para a seleção dos artigos, foram utilizados critérios de inclusão como: artigos completos, disponíveis em português, inglês e espanhol e que abordavam a questão norteadora do estudo. Resultados: As buscas foram realizadas nas bases de dados PubMed, na Biblioteca Virtual de Saúde (BVS) e na Scielo, tendo como resultado um total de 1251 estudos, sendo 490 na PubMed, 550 na BVS e 211 na Scielo. Foram excluídos, após a leitura dos títulos e resumos um total de 1149 estudos, sendo 418 na PubMed, 530 na BVS e 201 na Scielo, restando 102 estudos. Após a leitura minuciosa dos artigos na integra, foram selecionados 13. Considerações Finais: destaca-se que desde o surgimento do novo coronavírus, houve um aumento da propagação de notícias falsas relacionadas a esse novo vírus, o que contribuiu para infodemia e sensações de preocupação por parte da população.
A contribuição da psicologia na saúde mental dos atletas no âmbito esportivo: uma pesquisa bibliográfica
Authors: Silva Carlos Magno Teixeira da , Dias Fernando Gonçalves , Sousa Marcelo Costa de , Oliveira Viviane Pacheco de , Oliveira Keylane Batista de , Farias Ruth Raquel Soares de
Published: September 2022

A inserção da Psicologia no contexto esportivo consiste em conquistar seu espaço e desenvolver suas práticas em equipe, para que suas atividades sejam realizadas com êxito, promover o bem-estar e o rendimento nos resultados dos atletas em treinos, pois o mesmo tem o papel de contribuir na redução, tensões e pressões psicológica adquirida pelos os atletas. O objetivo geral deste artigo é investigar a influência da Psicologia do esporte na integridade física e mental do atleta. Enquanto os objetivos específicos são conhecer as principais doenças mentais que os atletas podem apresentar; verificar a importância da psicologia no esporte, além de identificar os possíveis fatores que contribuem para o adoecimento, mental e física dos atletas. Para a realização da mesma, foram analisados artigos publicados em revistas científicas, utilizando como fonte bases de dados National Library of Medicine (PUBMED), BVS (Biblioteca Virtual da Saúde), como Lilacs (Literatura Latino-Americana e do Caribe em Ciências da Saúde) e SciELO (Scientific Electronic Library Online), considerando a palavras-chave: psicologia; esporte e saúde mental. Após a análise dos resultados, quanto aos critérios de escolha, consideraram as publicações que atenderam a temática do estudo, publicadas na íntegra, com textos completos disponíveis, sendo artigos científicos ou teses, nos idiomas: português,inglês e espanhol publicadas entre 2018 e 2022. Foram encontrados um total de 18 artigos nas bases cientificas: Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), National Library of Medicine (PUBMED), Biblioteca Virtual em Saúde – (BVS), Scientific Eletronic Library Online (SCIELO). Nessa revisão observamos que a maioria dos pesquisadores que abordaram esse tema demonstraram em suas pesquisas e artigos as influências que acometem os atletas em processo de profissionalização e como um preparo psicológico durante esta experiência se mostra significativamente positiva.
Observation of zebrafish embryonic and larval development at different doses of curcumin solution: the disparity between safe and toxic
Authors: Andrade Leandro Almeida Domiciano de , Casetta Jaisa , Braccini Graciela Lucca , Ribeiro Ricardo Pereira
Published: September 2022

The aim of the study is to perform a fast and efficient toxicity test that demonstrates the safety or toxicity levels in the embryonic development of zebrafish exposed to different doses of curcumin. Embryotoxicity tests were performed according to the OECD guideline. A standard dose of 100 mg/kg curcumin per zebrafish embryo weight was determined. A stock solution was dissolved in dimethylsulfoxide and then used to perform a serial dilution in dechlorinated water to identify safe levels of curcumin concentration. The test was performed at concentrations of 0.6; 1.25; 2.50; 5; 6.25; 10; 12.5; 25; 50; 100 μM/mL, together with a control standard containing only dechlorinated water. After the start of exposure, the embryos were monitored with an optical microscope at 8, 24, 48, 72, and 96 hours post-exposure to identify possible changes and mortality. We observed that higher doses of curcumin solution influence the appearance of teratogenic characteristics such as eye malformation, retarded growth, yolk edema, crooked syrup, and short syrup. The results were also analyzed from the embryonic survival rate from the doses used, concluding that at higher concentrations, there was a significant difference in survival.
Estudo da qualidade de triagem no atendimento pré-hospitalar ao trauma através dos protocolos numérico e por cores
Authors: Silva Lais Aparecida , Cavazana William Cesar
Published: September 2022

Introdução: Em 2004 iniciou-se no Brasil o Acolhimento com Classificação de Risco (ACCR) para pacientes em pronto-atendimentos intra-hospitalar. No atendimento pré-hospitalar a triagem com a classificação de risco auxilia na separação das vítimas conforme a gravidade dos ferimentos, o mecanismo da lesão e os critérios fisiológicos; visando um transporte adequado e um destino coerente ao paciente. Objetivo: Este estudo analisou as triagens das vítimas de trauma socorridas nos trechos da Concessionária Econorte, na região Norte do Paraná-Brasil. Método: Realizou-se uma pesquisa bibliográfica na base de dados “PubMed” e um estudo sistemático qualitativo e quantitativo dos Boletins de Ocorrência preenchidos pelos socorristas da Concessionária e das fichas de Controle de Atendimento da central de regulação da Concessionária através de uma pesquisa retrospectiva de coorte em dois períodos: de 01 de janeiro de 2015 a 31 de dezembro de 2016 e 01 de janeiro de 2019 a 31 de dezembro de 2020. Resultados: As descrições do perfil dos acidentados, posições das vítimas, local do acidente e taxas de subtriagem e supertriagem foram obtidas e presentadas em tabelas e gráficos. Conclusão: O número de Boletins de Ocorrência com preenchimento adequado foi maior no segundo período e neles a classificação de risco das vítimas estavam registradas. Dentre as classificações de risco inadequadas, tanto nas análises dos Boletins de Ocorrência quanto das fichas de Controle de Atendimento houve predomínio de subtriagem nos dois períodos analisados.
Canvas da Tecnologia Social: metodologia para criação de projetos
Authors: Freitas Carlos Cesar Garcia , Vencio Daniele Alves Camargo , Freitas Flaviane Pelloso Molina
Published: September 2022

O Brasil apresenta diversos problemas sociais e a Tecnologia Social (TS) coloca-se como uma alternativa para a construção e a implantação de soluções que visam reduzir as desigualdades e melhorar a qualidade de vida das comunidades. Contudo, carece de metodologias adequadas que possam orientar seu processo de criação. Assim, o presente artigo tem o objetivo de apresentar uma ferramenta de modelagem de projetos para utilização na criação das TS, desenvolvida com base nos Modelos de Negócios Canvas e Canvas Social. Para tanto, foi desenvolvida uma pesquisa de caracter descritiva, com abordagem qualitativa por meio de análise bibliográfica narrativa. Como resultado do estudo é apresentado o Canvas-TS que tem como diferencial o atendimento aos aspectos de apropriação, participação e aprendizagem das pessoas envolvidas com os projetos de TS. Seu design está estruturado em quatro grupos de elementos que visam responder questões chaves envolvidas na criação de um projeto, sendo: como (necessidade, solução do problema, parcerias e medição de resultados), o que (proposta de valor), por quem (corresponsáveis, participação, canais e apropriação) e quanto (gastos e financiamento).
Realidade Aumentada como apoio ao ensino de Ciências no contexto da pandemia por Covid-19: um estudo de caso
Authors: Ferreira Carlos Eduardo Antônio , Mazon Josete , Pozzebon Eliane , Okada Alexandra , Costa Alexandre Marino
Published: September 2022

Devido a pandemia por Covid-19 o ensino passou a ser remoto necessitando diariamente inovar para as aulas serem atrativas aos estudantes. O objetivo deste artigo é apresentar uma investigação, por meio de uma intervenção didática apoiada pela ferramenta de Realidade Aumentada (RA), a compreensão das células do corpo humano durante uma aula de ciências para alunos do ensino fundamental. Foi criado um estudo de caso aplicado com 53 estudantes do nono ano do ensino fundamental na disciplina de Ciências. Os alunos foram estimulados a utilizar cartões com RA e interagirem com seus familiares explicando o conteúdo sobre as células, utilizando a mesma tecnologia. Os resultados mostraram que a RA é uma importante ferramenta para apoiar as aulas de ciências no conteúdo de células do corpo humano, tornando visível o que ficaria somente na imaginação e possibilitou a interação com as estruturas celulares, melhorando o aprendizado. A tecnologia com RA auxiliou o aprendizado dos estudantes e ao mesmo tempo contribuiu para a atividade ser interessante e divertida, motivando os estudantes durante o processo de aprendizagem.
Fatores que interferem na participação social de idosos com perda auditiva
Authors: Santos Israel Bispo dos , Morais Everton Adriano de , Lacerda Adriana , Guarinello Ana Cristina
Published: September 2022

No decorrer das últimas décadas a discussão sobre ações e fatores que favoreçam uma comunicação mais efetiva de idosos com perda auditiva tornou-se meta de muitos profissionais. Objetivo: Analisar a visão de idosos com perda auditiva, usuários e não usuários de Aparelhos auditivos (AASI), acerca de fatores que influenciam sua participação social. Método: Os participantes desta pesquisa foram recrutados em uma clínica-escola de Fonoaudiologia credenciada ao SUS, localizada na região sul brasileira e foram divididos em 2 grupos: Grupo 1 n=51 -idosos com perda auditiva usuários de AASI, grupo 2 n=31-idosos com perda auditiva não usuários de aparelho de amplificação sonora individual (AASI). Foram aplicados os seguintes instrumentos:1) questionário para delinear as características sócio demográficas das duas populações, 2) instrumento internacional (LIFE H 3.1) e 3) questionário (HHIEs). Resultados: Alguns fatores que interferem na participação social de idosos de ambos os grupos, foram: moradias precárias, baixa aposentadoria, poucos recursos financeiros que dificultam o acesso a saúde. Na aplicação do HHIES não foram encontradas diferenças significativas entre os grupos; já no LIFE-H 3.1 houve diferenças significativas no cruzamento com a perda auditiva no Grupo 01 para a área da Comunicação e no Grupo 02 para as áreas Condicionamento físico e Educação (p=0,36). Conclusão: A falta de recursos pode levar ao idoso com perda auditiva a uma vida sem lazer e interações salutares. O AASI se mostrou um dispositivo importante para que os idosos com perda auditiva possam melhorar suas relações sociais e as interações com os outros.
Tissue repair under the influence of plasma jet and other biomodulator therapies - state of the art
Authors: Cerqueira Carla Barreto Silva de , Dantas Juliana Borges de Lima , Souza Bárbhara Garden Salvino de , Carvalho Mylana Almeida de , Medrado Alena Ribeiro Alves Peixoto , Matos Josilene Borges Torres Lima
Published: September 2022

Tissue repair process consists in a complex and dynamic event straightly linked to tissues self-regeneration capability. In that context, it may also occur total or partial replacement of the original tissues through an extracellular matrix with significant collagen and elastin expression that results in fibroplasia. Aiming to optimizing the repair, it has been used some resources able to biomodulate the action of different kinds of tissue cells such as laser photobiomodulation (LP), light emitting diodes (LEDs), ozone therapy and plasma jet. This narrative literature review aims to describe the different phases of tissue repair and discuss about biomodulator therapies commonly applied to stimulate that process. Manuscripts discussing the proposal theme, which have been fully available were selected from Pubmed, Embase, Cochrane and Scielo database. The manuscripts must be written in English or Portuguese language, according to the exclusion and inclusion criteria designed for that study. Sixty manuscripts were selected. It may be noticed that biomodulator therapies have been used in health areas. However, studies evaluating the influence of plasma jet on tissue repair are still scarce. Preliminary results from such studies suggest that plasma jet therapy may perform important antiinflammatory, analgesic and biostimulating effects.
Investigação sobre o perfil profissional do professor de sala de recursos multifuncionais do município de Niterói-RJ
Authors: Bandeira Paola Martins Bagueira Pinto , Gomes Suzete Araujo Oliveira
Published: September 2022

O Atendimento Educacional Especial (AEE) é objeto de estudo de muitos pesquisadores, cujo propósito é investigar como ocorrem as intervenções junto aos alunos público-alvo da Educação Especial. Este trabalho teve como objetivo conhecer o perfil dos profissionais responsáveis pelo AEE nas Salas de Recursos Multifuncionais (SRMs) de escolas de dois polos da Rede Municipal de Educação de Niterói, município do estado do Rio de Janeiro. O levantamento e a análise dos dados, deu-se por meio do método misto quanti-qualitativo. A coleta de dados para traçar o perfil do profissional foi feita por meio de questionário e entrevista semiestruturada. Os resultados das entrevistas possibilitaram uma visão concreta do atual cenário dos professores das SRMs das escolas pesquisadas, bem como sobre o conhecimento das práticas, intervenções, recursos e materiais de Tecnologia Assistiva aplicadas no Atendimento Educacional Especializado (AEE) essenciais para o processo de ensino-aprendizagem na educação inclusiva.
COVID-19: Aspectos clínicos e epidemiológicos no interior da Amazônia brasileira
Authors: Silva Camila de Almeida , Souza Luciana Inácia de , Fernandes Franciane de Paula
Published: September 2022

A COVID-19 é uma patologia causada pelo vírus SARS-CoV-2, que pode afetar negativamente os indivíduos infectados, variando de sintomas leves a moderados ou graves. O primeiro caso de COVID-19 foi relatado no Brasil em 26 de fevereiro de 2020. Enquanto, a OMS e as autoridades sanitárias mundiais trabalham para conter o surto, a crise sanitária promove repercussões significativas na saúde humana e no bem-estar da população. Trata-se de um estudo epidemiológico quantitativo, observacional, descritivo e de aspecto transversal cujos dados foram disponibilizados por meio do Sistema de Monitoramento Estadual do setor de vigilância epidemiológica da Secretaria de Estado da Saúde do Pará. Tem como objetivo realizar uma análise epidemiológica e clínica dos casos confirmados de COVID-19 no município de Santarém-PA. Identificou-se que, no período de janeiro a dezembro de 2021, ocorreram 15539 casos confirmados e o perfil epidemiológico foi de pacientes do sexo feminino (55,67%), com idade entre 30-39 anos (21,89%) e com 3,65% (567) dos casos evoluindo para o óbito, sendo a maioria homens. Quanto ao perfil clínico, os sintomas mais frequentes foram tosse (63,84%), febre (761,1%), cefaleia (49,78%) e dor de garganta (48,83%). Enquanto, as morbidades mais referidas foram, respectivamente, diabetes (3,26%), cardiopatias (1,99%) e imunodeficiência/ imunodepressão (0,88%). Pode-se concluir que esses dados corroboram com analises epidemiológicas no estado do Pará, contribuindo a nível informacional para novas ações no âmbito da saúde.
Hemofilia: Fisiopatologia e Diagnóstico
Authors: Oliveira Antônio Bartolomeu Teixeira de , Magalhães Edivane Queiroz de , Silva Elizabeth Carvalho da , Silva Gerson Luiz da Silva e , Ladislau Rebeca Simão , Silva Francisco Gabriel Carvalho da , Rodrigues Júnior Omero Martins
Published: September 2022

Introdução: A hemofilia é uma patologia hemorrágica rara, hereditária e caracterizada pela falta de fatores de coagulação como o fator VIII (Hemofilia A) e o fator IX (Hemofilia B), o que provoca sangramentos espontâneos e artropatias incapacitantes. A mesma pode ser de forma congênita, sendo a mais comum, ou de forma adquirida. A forma hereditária se dá por mutações nos genes que codificam esses fatores de coagulação, e é uma herança recessiva ligada ao cromossomo X. Já a adquirida ocorre através de doenças autoimunes e está relacionada a presença de auto anticorpos. Objetivo: o objetivo deste trabalho é levantar informações sobre a hemofilia, discorrendo sobre a doença desde o seu desenvolvimento até seu diagnóstico. Metodologia:a pesquisa foi desenvolvida através de buscas nas plataformas Scielo (Biblioteca Eletrônica Scientifc Eletronic Library Onlinne) e Google acadêmico. Sendo baseado uma revisão de literatura, segundo Cunha, Cunha & Alves, (2014). Foram usados como descritores: Hemofilia; Fatores de coagulação; Diagnóstico. Conclusão: A partir de revisão apresentada, podemos concluir que a Hemofilia é uma doença hereditária recessiva ligada ao cromossomo x que o portador não apresenta ou há produção imperfeita do fator VIII ou o fator IX. Além disso, pode ser classificada a partir da quantidade dos fatores deficitários circulantes no plasma em três categorias: grave (menor do que 1%); moderada (de 1% a 5%) e leve (acima de 5%).
An Evaluation on Health Communication Problems of Asylum Seekers and Refugees
Authors: YEŞİLYURT Özgür , SAVAŞCI Emine
Published: September 2022

Farklı kültürlerin bir araya gelmesi sonucu ortak dil kullanamamaktan kaynaklanan iletişim problemi, sağlık kurumlarında teşhis ve tedavi sürecini sekteye uğratmaktadır.
Çalışmada amaçlanan, sağlık iletişim sorunlarını sığınmacı ve mültecilerin gözünden değerlendirip öneriler sunmaktır. Ülkemizde giderek artan sığınmacı ve mülteci sayısı ile doğru orantılı olarak sorunlar da artmaktadır. Dolayısıyla konunun farklı bağlamlarda irdelenmesi, soruna dikkat çekip sunulan önerileri uygulamaya geçirmek adına önemlidir.
Çalışmada, kolayda örnekleme ile seçilen Konya’daki 20 yabancı bireyle yarı yapılandırılmış görüşme yapılmıştır. Yapılan tematik analiz sonucunda 3 ana tema oluşturulmuştur. Birinci tema, sağlık kurumu tercihleri ve nedenleridir. Sağlık kurumu tercihleri kategorisi, kamu sağlık kurumları ve özel sağlık kurumları olarak 2 alt koda ayrılmıştır. Tercih etme nedenleri kategorisi ise hizmet kalitesi, konum, iletişim, hastalığın ciddiyeti olarak 4 alt koda ayrılmıştır. İkinci tema, hastalık ve tedavi sürecinde iletişimdir. Bu temayı oluşturan alt kodlar 8’e ayrılmıştır: Bireysel iletişim, kurumsal iletişim, randevu problemleri, yanlış teşhis, tedavi problemleri, hekim değişikliği, yüksek ücretler, sağlık personelinin olumlu tutum ve davranışlarıdır. Üçüncü tema, sağlık kurumlarına önerilerdir. Bu temayı oluşturan alt kodlar; dil desteği sağlanması, randevu sisteminin düzenlenmesi ve ücretsiz tedavi imkânı sunulması olarak 3’e ayrılmıştır.
Sığınmacı ve mülteci bireyler, yeterli dil desteği olmayan sağlık kurumlarında sorun yaşamaktadır. Sağlık personelinin olumlu tutumu ile süreç kolaylaşmakta veya zorlaşmaktadır.
Posology and Serum-/Xeno-Free Engineered Adipose Stromal Cells Cell Sheets
Authors: Ochiai Jun , Villanueva Larakaye , Niihara Hope , Niihara Yutaka , Oliva Joan
Published: September 2022

Well-characterized adipose stem cells and chemically defined culture media are important factors that control the production of the cell sheet, used in translational medicine. In this study, we have developed and engineered multilayer adipose stem cell cell sheets (ASCCSs) using chemically defined/serum-free culture media: undifferentiated or differentiated into osteoblasts and chondrocytes. In addition, using the cell sheet transmittance, we estimated the number of cells per cell sheet. Undifferentiated ASCCSs were engineered in 10 days, using serum-free/xeno-free culture media. They were CD29+, CD73+, CD90+, CD105+, HLA-A+, and HLA-DR-. ASCCSs differentiated into chondrocytes and osteoblasts were also engineered using chemically defined and animal-free culture media, in only 14 days. The addition of an ROCK inhibitor improved the chondrocyte cell sheet engineering. The decrease in the cell sheet transmittance rate was higher for the osteoblast cell sheets due to the intracellular Ca2+ accumulation. The estimation of cell number per cell sheet was carried out with the transmittance, which will provide important information for cell sheet posology. In conclusion, three types of ASCCSs were engineered using serum-free, xeno-free culture media, expressing their specific markers. Their transmittance measurement allowed estimating the number of cells per cell sheet, with a non-invasive methodology.
Study on key influencing factors of competitive adsorption of coalbed methane by carbon dioxide displacement
Authors: Zhang Xin , Huang Gun , Shu Zhile , Tong Yao
Published: September 2022

The extraction of coal bed methane (CBM) by injecting CO2 into deeply buried unmined coal seams in competition with CH4 adsorption to provide a clean fuel is known as enhanced coal bed methane recovery (ECBM) and has proven to be an effective technological strategy to address global warming. The study of the interaction of coal with CO2 and CH4 under multi-physical field conditions is particularly necessary. In this work, a series of experiments were conducted on a home-made test system to investigate the competing sorption patterns of high and medium ash coal samples subjected to variables such as gas pressure, temperature, nodulation and lateral limit constraints. The results show that there is a sorption isotherm relationship between coal samples and exposure time. The adsorption capacity sorption of CH4/CO2 varied considerably for different ash coal samples. As the CO2 pressure increased from 2.3 to 5.5 MPa, the strain on the coal samples increased from 0.082 to 0.4%. The deformation in the vertical laminae direction is always greater than that in the parallel laminae direction. A correlation coefficient K exists between 1 and 2, and there is an internal expansion pattern in the adsorption deformation of coal. This paper can contribute to the improvement of ECBM efficiency.
Long-term single-lead electrocardiogram monitoring to detect new-onset postoperative atrial fibrillation in patients after cardiac surgery
Authors: He Kang , Liang Weitao , Liu Sen , Bian Longrong , Xu Yi , Luo Cong , Li Yifan , Yue Honghua , Yang Cuiwei , Wu Zhong
Published: September 2022

Background

Postoperative atrial fibrillation (POAF) is often associated with serious complications. In this study, we collected long-term single-lead electrocardiograms (ECGs) of patients with preoperative sinus rhythm to build statistical models and machine learning models to predict POAF.

Methods

All patients with preoperative sinus rhythm who underwent cardiac surgery were enrolled and we collected long-term ECG data 24 h before surgery and 7 days after surgery by single-lead ECG. The patients were divided into a POAF group a no-POAF group. A clinical model and a clinical + ECG model were constructed. The ECG parameters were designed and support vector machine (SVM) was selected to build a machine learning model and evaluate its prediction efficiency.

Results

A total of 100 patients were included. The detection rate of POAF in long-term ECG monitoring was 31% and that in conventional monitoring was 19%. We calculated 7 P-wave parameters, Pmax (167 ± 31 ms vs. 184 ± 37 ms, P = 0.018), Pstd (15 ± 7 vs. 19 ± 11, P = 0.031), and PWd (62 ± 28 ms vs. 80 ± 35 ms, P = 0.008) were significantly different. The AUC of the clinical model (sex, age, LA diameter, GFR, mechanical ventilation time) was 0.86. Clinical + ECG model (sex, age, LA diameter, GFR, mechanical ventilation time, Pmax, Pstd, PWd), AUC was 0.89. In the machine learning model, the accuracy (Ac) of the train set and test set was above 80 and 60%, respectively.

Conclusion

Long-term ECG monitoring could significantly improve the detection rate of POAF. The clinical + ECG model and the machine learning model based on P-wave parameters can predict POAF.
Association of Female Menopause With Atrioventricular Mechanics and Outcomes
Authors: Sung Kuo-Tzu , Chandramouli Chanchal , Lo Chi-In , Tsai Jui-Peng , Lai Yau-Huei , Hsiao Chih-Chung , Tsai Shin-Yi , Yun Chun-Ho , Hung Ta-Chuan , Kuo Jen-Yuan , Lin Jiun-Lu , Hou Charles Jia-Yin , Chen Ying-Ju , Su Cheng-Huang , Hung Chung-Lieh , Bulwer Bernard E. , Yeh Hung-I , Lam Carolyn S. P.
Published: September 2022

Background

Despite known sex differences in cardiac structure and function, little is known about how menopause and estrogen associate with atrioventricular mechanics and outcomes.

Objective

To study how, sex differences, loss of estrogen in menopause and duration of menopause, relate to atrioventricular mechanics and outcomes.

Methods

Among 4051 asymptomatic adults (49.8 ± 10.8 years, 35%women), left ventricular (LV) and left atrial (LA) mechanics were assessed using speckle-tracking.

Results

Post-menopausal (vs. pre-menopausal) women had similar LV ejection fraction but reduced GLS, reduced PALS, increased LA stiffness, higher LV sphericity and LV torsion (all p < 0.001). Multivariable analysis showed menopause to be associated with greater LV sphericity (0.02, 95%CI 0.01, 0.03), higher indexed LV mass (LVMi), lower mitral e’, lower LV GLS (0.37, 95%CI 0.04–0.70), higher LV torsion, larger LA volume, worse PALS (∼2.4-fold) and greater LA stiffness (0.028, 95%CI 0.01–0.05). Increasing years of menopause was associated with further reduction in GLS, markedly worse LA mechanics despite greater LV sphericity and higher torsion. Lower estradiol levels correlated with more impaired LV diastolic function, impaired LV GLS, greater LA stiffness, and increased LV sphericity and LV torsion (all p < 0.05). Approximately 5.5% (37/669) of post-menopausal women incident HF over 2.9 years of follow-up. Greater LV sphericity [adjusted hazard ratio (aHR) 1.04, 95%CI 1.00–1.07], impaired GLS (aHR 0.87, 95%CI 0.78–0.97), reduced peak left atrial longitudinal strain (PALS, aHR 0.94, 95%CI 0.90–0.99) and higher LA stiffness (aHR 10.5, 95%CI 1.69–64.6) were independently associated with the primary outcome of HF hospitalizations in post-menopause. Both PALS < 23% (aHR:1.32, 95%CI 1.01–3.49) and GLS < 16% (aHR:5.80, 95%CI 1.79–18.8) remained prognostic for the incidence of HF in post-menopausal women in dichotomous analyses, even after adjusting for confounders. Results were consistent with composite outcomes of HF hospitalizations and 1-year all-cause mortality as well.

Conclusion

Menopause was associated with greater LV/LA remodeling and reduced LV longitudinal and LA function in women. The cardiac functional deficit with menopause and lower estradiol levels, along with their independent prognostic value post-menopause, may elucidate sex differences in heart failure further.
The Relationship Between the Utilization of Arterial Blood Gas Analysis and Rehospitalization in Heart Failure: A Retrospective Cohort Study
Authors: Zhang Xinyu , Sun Yijun , Zhang Hui , Lu Huixia , Ji Xiaoping
Published: September 2022

Background

The most common presentation of decompensated HF is dyspnea, and arterial blood gas analysis is an excellent tool for the decision-making process for most dyspneic patients. However, data on the prognostic value of ABG in HF patients are limited. Herein, a retrospective cohort study was conducted to investigate whether the utilization of arterial blood gas analysis was independently associated with re-hospitalization in patients with heart failure.

Methods

As a retrospective cohort study, the relevant clinical data of hospitalized patients admitted to Zigong Fourth People's Hospital, Sichuan, China from December 2016 to June 2019 with a diagnosis of HF were analyzed. The re-hospitalization within 6 months and the use of intravenous diuretic, nitrates, inotropes, or vasopressors were compared between patients with and without arterial blood gas analysis. We used a multivariable logistic regression model, propensity score analysis, and an inverse probability-weighting model to ensure the robustness of our findings.

Results

We included 1,605 patients with heart failure. The overall re-hospitalization rate within 6 months was 38.2%; it was 34.8% and 41.8% for heart failure patients with or without arterial blood gas analysis, respectively. In the inverse probability-weighting model, the use of arterial blood gas analysis was associated with a 26% lower re-hospitalization rate within 6 months.

Conclusion

The performance of arterial blood gas analysis is associated with a 6-month rehospitalization rate benefit in a general population of heart failure patients. This association warrants further investigation.
Case Report: A Rare Case of Severe Coronary Venous Spasm During Radiofrequency Ablation of Premature Ventricular Contraction
Authors: Sha Rina , Rong Bing , Maduray Kellina , Zhong Jingquan
Published: September 2022

Coronary venous spasm has never been reported during premature ventricular extrasystole ablation. We report a 20-year-old female patient who experienced a severe spasm of the great cardiac vein during radiofrequency ablation for premature ventricular contractions, which were relieved eventually by the administration of intracoronary nitroglycerine. The operation was successfully completed, leading to a long-term resolution of her palpitation symptoms.
Cardiovascular manifestations identified by multi-modality imaging in patients with long COVID
Authors: Murata Nobuhiro , Yamada Akimasa , Fujito Hidesato , Hashimoto Naoki , Nagao Tetsuro , Tanaka Yudai , Fukumoto Katsunori , Arai Riku , Wakamatsu Yuji , Ebuchi Yasunari , Monden Masaki , Kojima Keisuke , Hayashi Kentaro , Gon Yasuhiro , Okumura Yasuo
Published: September 2022

Background

The possibility of permanent cardiovascular damage causing cardiovascular long COVID has been suggested; however, data are insufficient. This study investigated the prevalence of cardiovascular disorders, particularly in patients with cardiovascular long COVID using multi-modality imaging.

Methods

A total of 584 patients admitted to the hospital due to COVID-19 between January 2020 and September 2021 were initially considered. Upon outpatient follow-up, 52 (9%) were suspected to have cardiovascular long COVID, had complaints of chest pain, dyspnea, or palpitations, and were finally enrolled in this study. This study is registered with the Japanese University Hospital Medical Information Network (UMIN 000047978).

Results

Of 52 patients with long COVID who were followed up in the outpatient clinic for cardiovascular symptoms, cardiovascular disorders were present in 27% (14/52). Among them, 15% (8/52) had myocardial injury, 8% (4/52) pulmonary embolisms, and 4% (2/52) both. The incidence of a severe condition (36% [5/14] vs. 8% [3/38], p = 0.014) and in-hospital cardiac events (71% [10/14] vs. 24% [9/38], p = 0.002) was significantly higher in patients with cardiovascular disorders than in those without. A multivariate logistic regression analysis revealed that a severe condition (OR, 5.789; 95% CI 1.442–45.220; p = 0.017) and in-hospital cardiac events (OR, 8.079; 95% CI 1.306–25.657; p = 0.021) were independent risk factors of cardiovascular disorders in cardiovascular long COVID patients.

Conclusions

Suspicion of cardiovascular involvement in patients with cardiovascular long COVID in this study was approximately 30%. A severe condition during hospitalization and in-hospital cardiac events were risk factors of a cardiovascular sequalae in CV long COVID patients.
Prevalence and factors associated with cognitive impairment in Chinese heart failure patients: A pilot study
Authors: Niu Qi , Liu WeiHua , Wang FengLing , Dong YanHong
Published: September 2022

Background

The prevalence of Cognitive impairment (CI) is high in patients with heart failure (HF). It leads to poor prognosis, such as self-care, hospital readmission and increased mortality. However, such information among Chinese population is unclear.

Objective

The purpose of this study was to examine the prevalence of CI in Chinese patients with HF, and explore its correlation with biomarkers and clinical factors to better manage HF patients with CI.

Methods

This study is a cross-sectional study of 200 hospitalized HF patients in China. The cognitive function of HF patients was assessed by the Montreal Cognitive Assessment (MoCA) and the Mini-Mental State Examination (MMSE).

Results

The majority are male (62.5%, n = 125), have primary school and below level of education (57.5%, n = 115), NYHA III and above (62%, n = 124). They have an average MoCA score of 15.10 ± 8.18, MMSE score of 19.55 ± 8.23. Age, NYHA class, and atrial fibrillation were independently associated with CI (p < 0.05). There was a significant association between CI and the 4th quartile of TNT (p = 0.013), and the 3rd and 4th quartile of NT-proBNP (p = 0.015, p = 0.038).

Conclusions

The prevalence of undiagnosed CI in Chinese HF patients is high (81%). HF patients with high levels of TNT or NT-proBNP or both values may be at risk of developing CI. Therefore, we suggest that HF patients with older age, atrial fibrillation, NYHA class II and III, as well as elevated TNT or NT-proBNP or both values to be followed up with a formal evaluation for CI. Nurses need to provide targeted health education program for cognitively impaired HF population to improve their self-care ability and nursing outcome.
Using theoretical frameworks to analyze democratic student–teacher engagement and autonomous learning for academic achievement in Zimbabwe
Authors: Magwa Logic , Mohangi Kamleshie
Published: September 2022

Positive student–teacher engagement that fosters independent and supported learning is the fulcrum for academic success. This paper investigates stakeholder opinions on the intrinsic importance of a democratic student–teacher relationship and autonomous learning in mediating students’ academic progress in Zimbabwean secondary schools. This case study’s qualitative data was gathered through interviews and focus groups. We used Foucault’s theory of power relations and the self-determination theory of motivation to frame our findings. The 40 participants from two secondary schools were general teachers (n = 12), guidance and counseling teachers (n = 2), educational psychologists (n = 2), and form 5 students (n = 24), selected through purposive sampling techniques. The data were analyzed using the thematic content analysis approach. Findings revealed participants’ perceptions that democratic student–teacher relationships and autonomous learning opportunities may serve as a panacea to enhance students’ participation, motivation, and overall academic performance. The study recommends in-service training to teachers regarding policies, directives, and public acts that inform and educate on how student–teacher relationships may be enhanced to foster autonomous learning. Future longitudinal studies could investigate the long-term effects of positive student–teacher engagement and teacher-supported autonomous learning on student academic achievement.
Efficacy and safety of ultrasound-guided microwave ablation versus surgical resection for Bethesda category IV thyroid nodules: A retrospective comparative study
Authors: Yang Jingjing , Zhang Ya , Li Xingjia , Zhao Yueting , Han Xue , Chen Guofang , Chu Xiaoqiu , Li Ruiping , Wang Jianhua , Huang Fei , Liu Chao , Xu Shuhang
Published: September 2022

Objective

The objective of this study was to assess the efficacy and safety of ultrasound-guided microwave ablation (MWA) for Bethesda IV thyroid nodules and to compare the outcomes, complications, and costs of MWA and thyroidectomy.

Methods

A total of 130 patients with Bethesda IV nodules were retrospectively reviewed, involving 46 in the MWA group and 84 in the surgery group. The local institutional review board approved this study. Patients in the MWA group were followed up at 1, 3, 6, and 12 months after the intervention. Postoperative complications, treatment time, and cost in the two groups were compared.

Results

Among 84 patients with 85 Bethesda IV nodules in the surgery group, postoperative pathology was benign lesions, borderline tumors, papillary thyroid carcinoma, follicular variant papillary thyroid carcinoma, follicular thyroid carcinoma, and medullary carcinoma in 44, 4, 27, 6, 3, and 1 cases, respectively. Malignant thyroid nodules were more prone to solid echostructure (86.11% vs. 72.72%), hypoechogenicity (55.56% vs. 13.63%), and irregular margin (47.22% vs. 13.63%) than benign lesions. The nodule volume reduction rate of patients at 12 months after MWA was 85.01% ± 10.86%. Recurrence and lymphatic and distant metastases were not reported during the follow-up period. The incidence of complications, treatment time, hospitalization time, incision length, and cost were significantly lower in the MWA group than in the surgery group (all p < 0.001).

Conclusions

MWA significantly reduces the volume of Bethesda IV nodules with high safety and is recommended for those with surgical contraindications or those who refuse surgical resection. Patients with suspicious ultrasound features for malignancy should be actively treated with surgery.