bluuebunny/crossref_metadata_2025 huggingface dataset:
COVID-19 Clinical Phenotypes: Presentation and Temporal Progression of Disease in a Cohort of Hospitalized Adults in Georgia, United States
Authors: da Silva Juliana F , Hernandez-Romieu Alfonso C , Browning Sean D , Bruce Beau B , Natarajan Pavithra , Morris Sapna B , Gold Jeremy A W , Neblett Fanfair Robyn , Rogers-Brown Jessica , Rossow John , Szablewski Christine M , Oosmanally Nadine , D’Angelo Melissa Tobin , Drenzek Cherie , Murphy David J , Hollberg Julie , Blum James M , Jansen Robert , Wright David W , Sewell William , Owens Jack , Lefkove Benjamin , Brown Frank W , Burton Deron C , Uyeki Timothy M , Patel Priti R , Jackson Brendan R , Wong Karen K
Published: December 2020

Background

The epidemiological features and outcomes of hospitalized adults with coronavirus disease 2019 (COVID-19) have been described; however, the temporal progression and medical complications of disease among hospitalized patients require further study. Detailed descriptions of the natural history of COVID-19 among hospitalized patients are paramount to optimize health care resource utilization, and the detection of different clinical phenotypes may allow tailored clinical management strategies.

Methods

This was a retrospective cohort study of 305 adult patients hospitalized with COVID-19 in 8 academic and community hospitals. Patient characteristics included demographics, comorbidities, medication use, medical complications, intensive care utilization, and longitudinal vital sign and laboratory test values. We examined laboratory and vital sign trends by mortality status and length of stay. To identify clinical phenotypes, we calculated Gower’s dissimilarity matrix between each patient’s clinical characteristics and clustered similar patients using the partitioning around medoids algorithm.

Results

One phenotype of 6 identified was characterized by high mortality (49%), older age, male sex, elevated inflammatory markers, high prevalence of cardiovascular disease, and shock. Patients with this severe phenotype had significantly elevated peak C-reactive protein creatinine, D-dimer, and white blood cell count and lower minimum lymphocyte count compared with other phenotypes (P < .01, all comparisons).

Conclusions

Among a cohort of hospitalized adults, we identified a severe phenotype of COVID-19 based on the characteristics of its clinical course and poor prognosis. These findings need to be validated in other cohorts, as improved understanding of clinical phenotypes and risk factors for their development could help inform prognosis and tailored clinical management for COVID-19.
Myocardial Fibrosis Among Antiretroviral Therapy-Treated Persons With Human Immunodeficiency Virus in South Africa
Authors: Shuldiner Scott R , Wong Lye-Yeng , Peterson Tess E , Wolfson Julian , Jermy S , Saad H , Lumbamba Mbalabu A J , Singh A , Shey M , Meintjes G , Ntusi N , Ntsekhe M , Baker J V
Published: December 2020

Background

Heart failure is a prominent cardiovascular disease (CVD) manifestation in sub-Sarahan Africa. Myocardial fibrosis is a central feature of heart failure that we aimed to characterize among persons with human immunodeficiency virus (PWH) in South Africa.

Methods

Cardiovascular magnetic resonance (CMR) imaging was performed among PWH with viral suppression and uninfected controls, both free of known CVD. Plasma levels of N-terminal pro B-type natriuretic peptide (NT-proBNP) were measured. Comparisons by human immunodeficiency virus (HIV) status were made using linear and logistic regression, adjusted for age, sex, and hypertension.

Results

One hundred thirty-four PWH and 95 uninfected persons completed CMR imaging; age was 50 and 49 years, with 63% and 67% female, respectively. Compared with controls, PWH had greater myocardial fibrosis by extracellular volume fraction ([ECV] absolute difference, 1.2%; 95% confidence interval [CI], 0.1–2.3). In subgroup analyses, the effect of HIV status on ECV was more prominent among women. Women (vs controls) were also more likely to have elevated NT-proBNP levels (>125 pg/mL; odds ratio, 2.4; 95% CI, 1.0–6.0). Among all PWH, an elevated NT-proBNP level was associated with higher ECV (3.4% higher; 95% CI, 1.3–5.5).

Conclusions

Human immunodeficiency virus disease may contribute to myocardial fibrosis, with an effect more prominent among women. Research is needed to understand heart failure risk among PWH within sub-Saharan Africa.
Osteosarcoma arising from acetabulum extended to femoral head through round ligament: a case report
Authors: Sasaki Toru , Gokita Tabu , Ae Keisuke , Tanizawa Taisuke , Hayakawa Keiko , Funauchi Yuki , Motoi Noriko , Matsumoto Seiichi
Published: December 2020

A skip metastasis was defined as a solitary separate focus of osteosarcoma occurring synchronously with a primary osteosarcoma in the absence of anatomic extension. The progression of skip metastasis is considered less likely because the articular cartilage acts as a barrier, so there have been few reports on progression of the extremity bone tumor across a joint. In our case report, the acetabular osteosarcoma progressed to the femoral head through the ligament of the femoral head. From the findings of magnetic resonance imaging and resected specimen and tissue specimen, we considered that the tumor progressed between ligament and synovial tissue covering the ligament, and not passing through the inside of the ligament. This case suggested a possibility that the tumor might progress through the synovium around the ligament of femoral head in the cases of osteosarcoma arising from the proximal femur and acetabulum.
Comparative effects of telephone versus in-office behavioral counseling to improve HIV treatment outcomes among people living with HIV in a rural setting
Authors: Kalichman Seth C , Katner Harold , Eaton Lisa A , Banas Ellen , Hill Marnie , Kalichman Moira O
Published: December 2020

With the expansion of telehealth services, there is a need for evidence-based treatment adherence interventions that can be delivered remotely to people living with HIV. Evidence-based behavioral health counseling can be delivered via telephone, as well as in-office services. However, there is limited research on counseling delivery formats and their differential outcomes. The purpose of this study was to conduct a head-to-head comparison of behavioral self-regulation counseling delivered by telephone versus behavioral self-regulation counseling delivered by in-office sessions to improve HIV treatment outcomes. Patients (N = 251) deemed at risk for discontinuing care and treatment failure living in a rural area of the southeastern USA were referred by their care provider. The trial implemented a Wennberg Randomized Preferential Design to rigorously test: (a) patient preference and (b) comparative effects on patient retention in care and treatment adherence. There was a clear patient preference for telephone-delivered counseling (69%) over in-office-delivered counseling (31%) and participants who received telephone counseling completed a greater number of sessions. There were few differences between the two intervention delivery formats on clinical appointment attendance, antiretroviral adherence, and HIV viral load. Overall improvements in health outcomes were not observed across delivery formats. Telephone-delivered counseling did show somewhat greater benefit for improving depression symptoms, whereas in-office services demonstrated greater benefits for reducing alcohol use. These results encourage offering most patients the choice of telephone and in-office behavioral health counseling and suggest that more intensive interventions may be needed to improve clinical outcomes for people living with HIV who may be at risk for discontinuing care or experiencing HIV treatment failure.
What the guide does not tell you: reflections on and lessons learned from applying the COM-B behavior model for designing real life interventions
Authors: Whittal Amanda , Atkins Lou , Herber Oliver Rudolf
Published: December 2020

Substantial inconsistency exists in the effectiveness of existing interventions to improve heart failure (HF) self-care, which can be partially explained by the fact that self-management interventions often lack theoretical models that underpin intervention development. The COM-B behavior model is a comprehensive theoretical framework that can be used to develop effective, theory-based interventions. The aim of this article is to highlight the challenges and practical solutions when applying the COM-B model to HF self-care, in order to provide useful support for researchers intending to use the model for designing behavior change interventions. “The Behaviour Change Wheel” handbook provides a step-by-step guide to understand and change behavior. When following the guide, some practical and methodological challenges were encountered. Lessons learnt to overcome these challenges are reported. Although the handbook is a comprehensive guide for designing behavior change interventions, a number of challenges arose. For example, the descriptions provided in the guide were not always sufficient to make solid judgments on how to categorize determinants; narrowing down intervention possibilities to a manageable number and prioritizing potential behavior change techniques over others involved a certain amount of subjectivity in an otherwise highly systematic and structured approach. For the encountered challenges, solutions are provided to illustrate how the model was applied practically to design theory-based behavior change interventions. This article provides a useful reference for researchers’ use of the COM-B behavior model, as it outlines challenges that may occur and potential solutions to overcome them.
Greater Trochanter Height: A Quantitative Predictor of Skeletal Maturity
Authors: Nelson Grant , Knapik Derrick M. , Janes Jessica L. , Liu Raymond W.
Published: December 2020

Background:

The purpose of this investigation was to develop a quantitative and reproductible method for estimating skeletal maturity based on measurements of the height of the bony greater trochanter (GT) using timing to 90% of final height as a gold standard.

Methods:

Bony GT height was measured using serial anteroposterior pelvic radiographs in 76 healthy pediatric patients obtained from the Bolton-Brush (BB) Study with corresponding Greulich-Pyle (GP) bone ages. Chronologic age at 90% of final height was calculated. GT height was then measured in 300 contemporary patients aged 4 to 18 years, evenly divided based on sex and race. Bony GT height was compared between BB and contemporary patients, while linear mixed-effects models were used to examine for potential predictors of years to 90% final height using patient sex, GP bone age and bony GT height measurements.

Results:

Bony GT height was measured in 303 radiographs from the BB Collection (n=37 males; n=39 females) with corresponding GP bone ages, chronological ages, and heights to represent skeletal maturity. Mean age at 90% final height was 13.3±0.6 years for males and 11.4±0.8 years for females. When controlling for patient age and sex, multiple regression analysis revealed that contemporary patients possessed significantly greater bony GT height (mean difference: 1.15 mm; P=0.001) when compared with BB patients. Multivariate analysis showed that combining bony GT height, GP bone age, and sex significantly predicted years to 90% total growth (P<0.001) and explained ∼85% (95% confidence interval for R
2: 82%-87%) of the total variance in years using 90% of final height, with sex, GP bone age, and GT height all significant contributors.

Conclusions:

Including bony GT height provides more accurate prediction of 90% final height when combined with GP bone age and sex. GT height offers an efficient and accurate parameter that may be utilized in pediatric orthopedic conditions requiring a quantitative estimate of bone age in children with prior pelvis or hip imaging.

Level of Evidence:

Level II—diagnostic study.
Surgically Treated Pediatric Hand and Fingers Palmar Wounds Caused by Metal Fences: Analysis Over a 5-Year Period
Authors: Simon Anne-Laure , Savidan Pauline , Plomion Chloé , Mas Virginie , Ilharreborde Brice , Jehanno Pascal
Published: December 2020

Background:

Hand wounds are frequent in children (31% of hand injuries) and one possible mechanism responsible for profound laceration is metal fences while climbing. These injuries usually require a surgical look to explore soft-tissue damages, but the literature is poor regarding surgical findings and outcomes after this kind of traumatism. The aim of the study was therefore to report a consecutive series of hand and finger wounds caused by metal fences in children, focusing on surgical findings and potential complications.

Methods:

All consecutive hand or finger deep wounds caused by metal fences treated between January 2013 and December 2018 were retrospectively reviewed. Inclusion criteria were age below 18 years and a minimum follow-up of 2 years. Complications and surgical revisions were analyzed.

Results:

A total of 1265 patients were operated for hand or finger deep wounds during the study period, among which 74 were caused by metal fences. The mean age at surgery was 11.3±0.4 years, and the majority of patients were men (80%). Associated injuries were found in 55.4% of the patients including nerves (n=29) or tendons sections/disinsertion (n=6), and sheath (n=16) and pulleys (n=6) tearing. At a mean follow-up of 2.6±0.2 years, 12% of the patients required revision surgery for an irreducible flexion contracture secondary to a contractile scar and consisted of complete scar excision and zigzag flap. Additional tenoarthrolysis was required during the procedure, for 6 patients because of a persisting flexion contracture after excision.

Conclusions:

Metal fences surgical palmar wounds in children are impressive lesions by their extended skin damages. Serious associated lesions (collateral pedicle or flexor tendons) were found in 1 case of 3. However, these injuries are not benign and should be carefully monitored clinically during the first postoperative month to look for potential contractile scars that can require revision.

Level of Evidence:

Level IV—retrospective cohort study.
Impact of p53, HIF1a, Ki-67, CA-9, and GLUT1 Expression on Treatment Outcomes in Locally Advanced Cervical Cancer Patients Treated With Definitive Chemoradiation Therapy
Authors: Gaber Germaine , El Achy Samar , Khedr Gehan A. , Parimi Vamsi , Helenowksi Irene , Donnelly Eric D. , Strauss Jonathan B. , Woloschak Gayle , Wei Jian-Jun , Small William , Refaat Tamer
Published: December 2020

Purpose/Objective:

The objective of this study was to assess the association between pretreatment p53, hypoxia inducible factor 1a (HIF1a), Ki-67, carbonic anhydrase-9 (CA-9), and glucose transporter 1 (GLUT1) expression in locally advanced cervical cancer patients treated definitively with concurrent chemoradiation therapy (CRT) and treatment outcomes including overall survival (OS), progression-free survival (PFS), local-regional control (LC), and distant metastases–free survival (DMFS).

Patients and Methods:

Twenty-eight patients treated definitively and consecutively for cervical cancer with CRT had p53, HIF1a, Ki-67, CA-9, and GLUT1 protein expression assessed and scored semiquantitatively by 3 pathologists, blinded to the treatment outcomes. Outcomes were stratified by p53 (H-score: <15 vs. ≥15), HIF1a (H-score: <95 vs. ≥95), Ki-67 (labeling index <41% vs. ≥41%), CA-9 (H-score: <15 vs. ≥15), and GLUT1 (H-score: <175 vs. ≥175) expression. OS, PFS, LC, and DMFS rates were calculated using the Kaplan-Meier method, and differences between groups were evaluated by the log-rank test.

Results:

Notable clinical characteristics of the cohort included median age of 51 years (range: 32 to 74 y), FIGO stage IIB disease (57.2%), clinical node-negative disease (64.3%), squamous cell carcinoma (89.3%), and adenocarcinoma (10.7%). Treatment outcomes included 5-year OS (57.2%), PFS (48.1%), LC (72.1%), and DMFS (62.9%). For HIF1a H-score <95 and ≥95, the 5-year OS (52.0% and 68.4%, P=0.58), PFS (53.0% and 40.9%, P=0.75), LC (71.6% and 68.2%, P=0.92), and DMFS (59.7% and 52.0%, P=0.91) were not significantly different. For Ki-67 labeling index <41% and ≥41%, the 5-year OS (44.9% and 66.6%, P=0.35), PFS (38.9% and 55.4%, P=0.53), LC (57.7% and 85.7%, P=0.22), and DMFS (67.3% and 61.0%, P=0.94) were not significantly different. For CA-9 H-score <15 and ≥15, the 5-year OS (54.4% and 66.7%, P=0.39), PFS (57.3% and 40.0%, P=0.87), LC (70.0% and 70.0%, P=0.95), and DMFS (70.0% and 46.7%, P=0.94) were not significantly different. For GLUT1 H-score <175 and ≥175, the 5-year OS (43.6% and 43.6%, P=0.32), PFS (55.6% and 49.5%, P=0.72), LC (72.9% and 71.5%, P=0.97), and DMFS (62.5% and 59.6%, P=0.76) were not significantly different. For p53, H-score <15 and ≥15, the 5-year OS (62% and 53%), PFS (63% and 30.3%), LC (87.5% and 52%), and DMFS (79.6% and 41.6%).

Conclusions:

In this study population, HIF1a, Ki-67, CA-9, and GLUT1 expression did not predict treatment response or outcomes in locally advanced cervical cancer patients treated definitively with CRT. There was a nonstatistically significant trend towards worse outcomes with p53 expression.
Preexisting Conditions That Kill Us
Authors: Hanna-Attisha Mona , Olson Erik D.
Published: December 2020

To protect human life, science and public health need to guide public policy. We call for an end to the anti-science, anti-prevention, and anti-regulatory policies that have resulted in countless preexisting conditions and deaths. Reactive responses are not a substitute for primary prevention; we must invest in environmental and public health protections.
Optimizing Care for Patients With Adverse Events From Immunotherapeutics
Authors: Sheehan Kelsey , Price Christina , Hafez Navid
Published: December 2020

Immune-related adverse events (irAEs) are a common occurrence in patients treated with immune checkpoint inhibitors. Fortunately, the majority of irAEs are mild and easily managed with steroids. As the use of immune checkpoint inhibitors and other immune therapies continues to increase across indications, so too will the need for managing irAEs. Optimal care for irAEs should include surveillance and early detection, guideline-driven management of standard irAEs, multidisciplinary expert involvement in complicated or steroid-refractory cases, and concurrent research to define predictive biomarkers and delineate the populations, which can be safely treated and retreated with immune therapies. In this article, we describe the implementation of a 3-pronged strategy used at our institution consisting of an Immune Wellness Clinic to risk stratify and monitor at-risk patients, an Immuno-Oncology Treatment Monitoring Repository to support translational research, and an Immunotoxicity Tumor Board to manage severe or complicated adverse events.
Moving Immunotherapy Into Early-Stage Lung Cancer
Authors: Linehan Anna , Forde Patrick M.
Published: December 2020

Blockade of the programmed cell death 1 immune inhibitory pathway has revolutionized the treatment of advanced non–small cell lung cancer and led to significant improvements in overall survival. In contrast, early-stage surgically resectable lung cancer has had few treatment advances in many years and continues to be associated with a high risk of relapse despite apparent curative resection. In this review, we discuss the many ongoing efforts to incorporate programmed cell death 1 pathway blockade into the treatment paradigm for surgically resectable lung cancer both as adjuvant and neoadjuvant therapy. We review the early-phase results from neoadjuvant clinical trials, the landscape of phase III trials that are ongoing, and look to the future of immune checkpoint blockade as a potential curative therapy for surgically resectable lung cancer.
NIH Workshop on HIV-Associated Comorbidities, Coinfections, and Complications: Summary and Recommendation for Future Research
Authors: Pahwa Savita , Deeks Steven , Zou Shimian , Tomitch Natalie , Miller-Novak Leia , Caler Elisabet , Justice Amy , Sacktor Ned , Gabuzda Dana , Hunt Peter W. , Brown Todd , Kurth Ann , Baral Stefan , Mugavero Michael , Mayer Kenneth H. , Mendenhall Emily , Detels Roger , Mutabazi Vincent
Published: December 2020

Background:

With potent antiretroviral therapy and simplified regimens, people living with HIV (PWH) are achieving near-normal lifespans but not necessarily a normal health span or healthy aging. PWH have a higher than expected risk of developing a number of non-AIDS comorbidities, coinfections, and complications (CCC), often against a background of stigma, poverty, and isolation.

Setting:

To gain a better understanding of research needs for HIV-associated CCC, the NIH convened a 2-day workshop (HIV-associated CCC, or HIV ACTION).

Methods:

A cross-institute NIH planning committee identified 6 key research areas: epidemiology and population research, pathogenesis and basic science research, clinical research, implementation science research, syndemics research and international research in low and middle income countries. Investigators were selected to lead working groups (WGs) to assess the state-of-the-art and identify 3–5 priority areas in each field before the workshop. A 2-day program at the NIH was developed which included presentations by invited experts and WG members.

Results:

Over 400 participants attended the workshop. After general and individual WG discussions, the most pressing gaps, questions, or proposed action items were identified. Priority lists of pressing research issues were presented by cochairs of each WG. A detailed report is posted at the NHLBI website. This article reports the streamlined priority list and a summary of WG discussions to inform investigators of current priorities in the field.

Conclusion:

Collaborative efforts of many disciplines are needed to improve the health and wellbeing of PWH. Several common themes emerged across WG representing potential priorities for investigators and recommendations for the NIH.
Bottom-up fabrication of a multi-component nanopore sensor that unfolds, processes and recognizes single proteins
Authors: Zhang Shengli , Huang Gang , Versloot Roderick , Herwig Bart Marlon , de Souza Paulo Cesar Telles , Marrink Siewert-Jan , Maglia Giovanni
Published: December 2020

Transmembrane channels and pores have many biotechnological applications, notably in the single-molecule sequencing of DNA. Small synthetic nanopores have been designed using amphipathic peptides, or by assembling computationally designed transmembrane helices. The fabrication of more complex transmembrane devices has yet to be reported. In this work, we fabricated in two steps a multi-protein transmembrane device that addresses some of the main challenges in nanopore protein sequencing. In the first step, artificial nanopores are created from soluble proteins with toroid shapes. This design principle will allow fabricating a variety of nanopores for single-molecule analysis. In the second step one α-subuinit of the 20S proteasome fromThermoplasma acidophilumis genetically integrated into the artificial nanopore, and a 28-component nanopore-proteasome is co-assembled inE. colicells. This multi-component molecular machine opens the door to two new approaches in protein sequencing, in which selected substrate proteins are unfolded, fed to into the proteasomal chamber and then identified by the nanopore sensor either as intact or fragmented polypeptides. The ability to integrate molecular devices directly onto a nanopore sensors allows creating next-generation protein sequencing devices, and will shed new lights on the fundamental processes of biological nanomachines.
Integrated analytical hierarchy process and grey relational analysis approach to measure supply chain complexity
Authors: Piya Sujan , Shamsuzzoha Ahm , Khadem Mohammed , Al Kindi Mahmoud
Published: December 2020

Purpose

The purpose of this paper is to understand the drivers that create complexity in the supply chain and develop a mathematical model to measure the level of supply chain complexity (SCC).

Design/methodology/approach

Through extensive literature review, the authors discussed various drivers of SCC. These drivers were classified into five dimensions based on expert opinion. Moreover, a novel hybrid mathematical model was developed by integrating analytical hierarchy process (AHP) and grey relational analysis (GRA) methods to measure the level of SCC. A case study was conducted to demonstrate the applicability of the developed model and analyze the SCC level of the company in the study.

Findings

The authors identified 22 drivers of SCC, which were further clustered into five complexity dimensions. The application of the developed model to the company in the case study showed that the SCC level of the company was 0.44, signifying that there was a considerable scope of improvement in terms of minimizing complexity. The company that serves as the focus of this case study mainly needs improvement in tackling issues concerning government regulation, internal communication and information sharing and company culture.

Originality/value

In this paper, the authors propose a model by integrating AHP and GRA methods that can measure the SCC level based on various complexity drivers. The combination of such methods, considering their ability to convert the inheritance and interdependence of drivers into a single mathematical model, is preferred over other techniques. To the best of the authors' knowledge, this is the first attempt at developing a hybrid multicriteria decision-based model to quantify SCC.
“We care about others”: discursive constructions of corruption vis-à-vis national/cultural identity in Indonesia’s business-government relations
Authors: Pertiwi Kanti
Published: December 2020

Purpose

This paper aims to problematize existing conceptualization of corruption by presenting alternative perspectives on corruption in Indonesia through the lens of national/cultural identity, amidst claims of the pervasiveness of corruption in the country. In so doing, the paper also sheds light on the micro-processes of interactions between global and local discourses in postcolonial settings.

Design/methodology/approach

The study applies discourse analysis, involving in-depth interviews with 40 informants from the business sector, government institutions and anti-corruption agencies.

Findings

The findings suggest that corruption helps government function, preserves livelihoods of the marginalized segments of societies and maintains social obligations/relations. These alternative meanings of corruption persist despite often seen as less legitimate due to effects of colonial powers.

Research limitations/implications

The snowballing method of recruiting informants is one of the limitations of this paper, which may decrease the potential diversity and lead to the silencing of different stories (Schwartz-Shea and Yanow, 2013). Researchers need to contextualize corruption and study its varied meanings to reveal its social, historical and political dimensions.

Practical implications

This paper strongly suggests that we need to move beyond rationalist accounts to capture the varied meanings of corruption which may be useful to explain the limited results of existing anti-corruption efforts.

Social implications

This study calls for a greater use of qualitative methods to study broad social change programs such as anti-corruption from the perspective of the insiders.

Originality/value

This paper contributes to the discussion of agency at the interplay between the dominant and alternative discourses in postcolonial settings. Moreover, the alternative meanings of corruption embedded in constructions of national identity and care ethics discussed in this paper offer as a starting point for decolonizing (Westwood, 2006) anti-corruption theory and practice.
Determinants of CSRD in non-Asian and Asian countries: a literature review
Authors: Abdullah Yasir , Ahmad-Zaluki Nurwati A. , Rahim Nazahah Abd
Published: December 2020

Purpose

The purpose of this paper is to review the current status of research works on corporate social responsibility disclosure (CSRD) in both non-Asian and Asian countries. It seeks to provide an overview of existing literatures to facilitate future research.

Design/methodology/approach

The present study used the content analysis of 64 empirical research papers from 41 countries from 1990 to 2020 to show the rapid development of and global focus on CSRD. Various CSRD measures had been used in previous researches on the extent and quality of disclosure.

Findings

Company characteristics, namely, company size, age, profitability, industry, share price performance and corporate governance mechanisms and their impact on CSRD, were investigated. Crucial variances between the determinants of CSRD in non-Asian and Asian countries were also reviewed. In non-Asian countries, especially the advanced ones, specific stakeholders such as regulators, the environment, shareholders, ownership and media are considered very significant in the disclosure of CSR information. Meanwhile, in Asian countries, CSRD is more affected by external strength and stakeholders, which include international capital markets, creditors, the environment, international media and ownership.

Research limitations/implications

The determinants of CSRD, namely, community, workplace, environment and marketplace issues received very little pressure from the public. This paper suggests that there is a need for more studies examining CSRD in non-Asian and Asian (emerging) countries.

Social implications

Business organisations in non-Asian and Asian countries should take social practices into consideration in their CSRD decision-making. This review highlights the significance of merging organisational and social activities.

Originality/value

This study adds value by examining CSRD aspects that were not reviewed in previous studies on CSRD in non-Asian and Asian countries. This study provides a comprehensive review of the determinants of CSRD in both non-Asian and Asian countries.
Exploring halal tourism in Muslim-minority countries: Muslim travellers’ needs and concerns
Authors: Said Mohd Fuaad , Adham Khairul Akmaliah , Muhamad Nur Sa’adah , Sulaiman Syahnaz
Published: December 2020

Purpose

This study focusses on the underlying needs of Muslims to adhere to the tenets of their religion and to guide their behaviours accordingly. These requirements, for the purpose of travelling, constitute halal tourism. As Muslim-minority nations, such as Taiwan, South Korea and Japan, began to market their own brands of halal tourism, there are concerns of whether their current practices are able to meet the requirements of Muslim travellers. Thus, this study aims to understand the main needs and concerns of Muslim travellers when they visit Muslim-minority countries.

Design/methodology/approach

Interviews were conducted on selected Muslim travellers who recently visited one of the following destinations, Japan, South Korea or Taiwan. Applying the process theory of travel, service marketing perspective and Muslim religious needs, the study’s conceptual framework served as the basis for crafting interview questions, selecting the participants and explaining the findings.

Findings

Muslim travellers are mostly concerned with the need to perform daily prayers and to find halal food at the point of need, and willing to conduct extensive research on the destination prior to their visit. Muslim travellers’ experiences in these Muslim-minority countries are generally met with their expectations, although further socialisation with the locals is needed to induce greater overall satisfaction with the destinations.

Practical implications

Understanding the current practices of halal tourism is critical so that improvements can be implemented in the industry.

Originality/value

Key preparations, expectations, actual experiences in the destinations and reflections of Muslim travellers provide in-depth insights into their needs and concerns when travelling in Muslim-minority countries. The emergent religion-based dimensions in service experience, such as availability of social agents and halal food at the point of need, extend the conceptualisation of perishability and heterogeneity in service marketing literature.
Retooling our anti-corruption arsenals: exploring the potential use of CAQDAS in corruption investigation
Authors: Prabowo Hendi Yogi
Published: December 2020

Purpose

This paper aims to explore the potential of computer-assisted qualitative data analysis software (CAQDAS) to be used as a corruption investigation tool to help investigators in carrying out their investigative works.

Design/methodology/approach

By reviewing the literature on qualitative research and fraud investigation, this exploratory study identifies similarities between the two types of inquiries and thus proposing the use of CAQDAS as an innovation in the field of corruption investigation. To demonstrate how a QDA application can support corruption investigators, NVivo is used as a case study from which various key analytical tools are discussed to highlight their potential in supporting a corruption investigation.

Findings

As a fundamental part of anti-corruption practice in a country, corruption investigation must be planned and executed professionally and adequately. This paper highlights various stages in fraud investigation to identify areas that can be improved with the use of a CAQDAS. Based on the discussion in this paper, the author concludes that the capability of a CAQDAS to assist users in data reduction and data display has the potential to increase the effectiveness and efficiency in various stages of a corruption investigation.

Research limitations/implications

Based on a self-funded study, this paper only uses a simulation case with a fictitious company to illustrate how a CAQDAS application can be used to support a corruption investigation process. Future studies may benefit from using actual corruption cases in illustrating how such an application can support the investigation process.

Practical implications

This paper contributes to the innovation in anti-corruption practice by proposing a new framework and tool to develop corruption investigation capacity.

Originality/value

This paper brings a new perspective into the field of anti-corruption to stimulate innovation in the area of corruption investigation.
Beliefs, knowledge and finite provinces of meaning: the case for science and the arts
Authors: Jácome de Moura Jr Pedro , Lauritzen Jácome Campos Cecília
Published: December 2020

Purpose

This paper aims to build around an abductive argument: the epistemological value of the Arts-derived knowledge is equivalent and may be supplementary to that of science, contributing to the literature on the epistemological mistrust between both systems of knowledge.

Design/methodology/approach

This essay proposes a conceptual model – a tool, in Kuhn’s terms – grounded on the sociology of knowledge (Berger and Luckmann, 1967; Schütz, 1951), to frame the apprehension of reality from a social perspective, and the philosophical pragmatism (Peirce, 2012), considering the fixation of beliefs as the seminal concept that leads to the legitimation of knowledge in society. The proposed conceptual model guides analysis on the epistemological value of the knowledge derived from the Arts and supports reflection on the commonalities between both finite provinces of meaning.

Findings

Reproducibility, doxastic grounding, community/membership, intersubjectivity and evidence are criteria identified as commonalities between the Arts and Science. Acceptance and legitimation across finite provinces of meaning emerge to produce minimally acceptable objectivity, made possible by the mutual validation of impressions.

Research limitations/implications

The discussion on greater levels of aesthetic appreciation has been eclipsed by the authors’ intention to find specific epistemological properties of knowledge derived from the Arts.

Practical implications

As practitioners in applied social science, management researchers are supposed to have mastery over how to apply what they know. So, the findings suggest participation (becoming accepted, first of all) in communities of practice, learning from and contributing to distinct finite provinces of meaning. The role of organizations in the understanding of knowledge derived from the Arts and its application might be that of a protagonist, promoting creativity and innovation through openness to new perspectives on knowledge.

Originality/value

This essay rescues knowledge as not a justified true belief, but the result of fixed beliefs continuously and socially legitimated. This rescue escapes previous attempts that appeal to Gettier-type counterexamples. A conceptual model was proposed to frame knowledge from a philosophical and sociological perspective and represent a methodological contribution of this essay. The proposition of third-order interdisciplinarity, also represents a contribution, of conceptual nature.
COVID-19: US shelter-in-place orders and demographic characteristics linked to cases, mortality, and recovery rates
Authors: Alderman Jillian , Harjoto Maretno
Published: December 2020

Purpose

This study aims to examine the relationship between the duration (in days) of states’ shelter-in-place orders; state demographic characteristics; and the rates of spread (cases), death (mortality), and recovery of COVID-19 in the USA.

Design/methodology/approach

State-level data across 50 states and Washington D.C. from January 23, 2020, to June 11, 2020, and a multivariate regression analysis were used to empirically investigate the impacts of the duration of shelter-in-place orders and state demographic characteristics on the rates of cases, mortality and recovery per capita of COVID-19.

Findings

This study finds that a longer duration of a shelter-in-place order is associated with lower cases and deaths per capita from COVID-19. This study also finds that demographic characteristics, such as the percentage of people who are unsheltered homeless, family size, percentage of individuals with health insurance, income inequality, unemployment rate, gender and race, are related to cases, mortality and recovery rates of COVID-19.

Social implications

This study offers policy implications for state and locality (e.g., city, region and country) lockdown decisions and salient demographics to consider curbing the spread and mortality rate of the COVID-19 pandemic. Study results are important to consider as the world braces for the anticipated resurgence of COVID-19.

Originality/value

This study reveals that the duration of shelter-in-place orders and demographics in states are related to the rates of spread, mortality, and recovery of COVID-19.
Democracy in flux: a systemic view on the impact of COVID-19
Authors: Parry Lucy J. , Asenbaum Hans , Ercan Selen A.
Published: December 2020

Purpose

The purpose of this paper is to demonstrate how a systemic view of democracy can provide insights into the myriad ways in which the COVID-19 pandemic affects democracies worldwide. This enables the authors to offer practical suggestions for strengthening democracy through meaningful participation in the spaces where deficits are most apparent.

Design/methodology/approach

The authors use the systems approach that has emerged from the deliberative and participatory democracy literature in recent years to map out the impacts of COVID-19. In this paper, the authors set out this approach as an agenda for future, more comprehensive research.

Findings

The authors’ preliminary overview suggests that democratic spaces are reconfigured during COVID-19, with participatory spaces shrinking, overlapping and invading each other. Based on the systemic overview, the authors suggest participatory interventions to address particular points of weakness such as accountability.

Originality/value

Taking a systemic approach to analysing COVID-19’s impacts on democracy enables the authors to understand the pressure points where democratic values and participation are under strain and where citizens’ participation is essential not only for strengthening democracy but also addressing the public health challenge of COVID-19.
Predicting the global invasion of Drosophila suzukii to improve Australian biosecurity preparedness
Authors: Maino James L. , Schouten Rafael , Umina Paul
Published: December 2020

Predicting biological invasions remains a challenge to applied ecologists and limits pre‐emptive management of biosecurity threats. In the last decade, spotted‐wing drosophila Drosophila suzukii has emerged as an internationally significant agricultural pest as it rapidly spread across Europe and the Americas. However, the underlying drivers of its global invasion remain unstudied, while countries like Australia, presently free from D. suzukii, require robust estimates of spread and establishment potential to aid development of effective preparedness strategies.

Here, we analysed the ecoclimatic and human‐mediated drivers of the global invasion of D. suzukii to understand historical spread patterns and improve forecasts of future spread potential. Using a modular approach, climate‐driven population dynamics were linked in space via dispersal processes to simulate spread at continental scales. Combined with biological parameters measured in laboratory studies, the spread model was parameterized and validated on international spread data.

Model accuracy was high and was able to predict 83% of regional presence–absence through time in the United States and, without further model fitting, 78% of the variation in the Europe incursion. Omitting human‐assisted spread from the model reduced predictability by over 20%, highlighting the large anthropogenic influence in this modern biological invasion. Economic activity (GDP) rather than human population density was more strongly associated with human‐mediated spread. Simulations predicted that eastern Australian coastal regions, particularly those near major cities with high economic activity, will result in the fastest spread of D. suzukii.

Synthesis and applications. Incursions of Drosophila suzukii into Australia will have significant consequences for horticultural industries with the predicted speed of spread making eradication programs extremely difficult. However, the identified areas of significant fruit production, and high environmental suitability and economic activity will form a logical means for prioritizing industry preparedness. In light of our findings, a key component of preparedness strategies will be the ability of fruit producers to rapidly transition to effective management of D. suzukii.
Understanding how health systems facilitate primary care redesign
Authors: Harvey Jillian B. , Vanderbrink Jocelyn , Mahmud Yasmin , Kitt‐Lewis Erin , Wolf Laura , Shaw Bethany , Ridgely M. Susan , Damberg Cheryl L. , Scanlon Dennis P.
Published: December 2020

Objective

To understand how health systems are facilitating primary care redesign (PCR), examine the PCR initiatives taking place within systems, and identify barriers to this work.

Study Setting

A purposive sample of 24 health systems in 4 states.

Study Design

Data were systematically reviewed to identify how system leaders define and implement initiatives to redesign primary care delivery and identify challenges. Researchers applied codes which were based on the theoretical PCR literature and created new codes to capture emerging themes. Investigators analyzed coded data then produced and applied a thematic analysis to examine how health systems facilitate PCR.

Data Collection

Semi‐structured telephone interviews with 162 system executives and physician organization leaders from 24 systems.

Principal Findings

Leaders at all 24 health systems described initiatives to redesign the delivery of primary care, but many were in the early stages. Respondents described the use of centralized health system resources to facilitate PCR initiatives, such as regionalized care coordinators, and integrated electronic health records. Team‐based care, population management, and care coordination were the most commonly described initiatives to transform primary care delivery. Respondents most often cited improving efficiency and enhancing clinician job satisfaction, as motivating factors for team‐based care. Changes in payment and risk assumption as well as community needs were commonly cited motivators for population health management and care coordination. Return on investment and the slower than anticipated rate in moving from fee‐for‐service to value‐based payment were noted by multiple respondents as challenges health systems face in redesigning primary care.

Conclusions

Given their expanding role in health care and the potential to leverage resources, health systems are promising entities to promote the advancement of PCR. Systems demonstrate interest and engagement in this work but face significant challenges in getting to scale until payment models are in alignment with these efforts.
Are health systems redesigning how health care is delivered?
Authors: Scanlon Dennis P. , Harvey Jillian B. , Wolf Laura J. , Vanderbrink Jocelyn M. , Shaw Bethany , Shi Yunfeng , Mahmud Yasmin , Ridgely M. Susan , Damberg Cheryl L.
Published: December 2020

Objective

To explore why and how health systems are engaging in care delivery redesign (CDR)—defined as the variety of tools and organizational change processes health systems use to pursue the Triple Aim.

Study Setting

A purposive sample of 24 health systems across 4 states as part of the Agency for Healthcare Research and Quality's Comparative Health System Performance Initiative.

Study Design

An exploratory qualitative study design to gain an “on the ground” understanding of health systems’ motivations for, and approaches to, CDR, with the goals of identifying key dimensions of CDR, and gauging the depth of change that is possible based on the particular approaches to redesign care being adopted by the health systems.

Data Collection

Semi‐structured telephone interviews with health system executives and physician organization leaders from 24 health systems (n = 162).

Principal Findings

We identify and define 13 CDR activities and find that the health systems’ efforts are varied in terms of both the combination of activities they are engaging in and the depth of innovation within each activity. Health system executives who report strong internal motivation for their CDR efforts describe more confidence in their approach to CDR than those who report strong external motivation. Health system leaders face uncertainty when implementing CDR due to a limited evidence base and because of the slower than expected pace of payment change.

Conclusions

The ability to validly and reliably measure CDR activities—particularly across varying organizational contexts and markets—is currently limited but is key to better understanding CDR’s impact on intended outcomes, which is important for guiding both health system decision making and policy making.