bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Syariah Marketing Terhadap Pelaksanaan Pemasaran Sabun Multibeauty
Authors: Dhuwi Puspita Sari  , Yunaita Rahmawati
Published: August 2023

This study aims to determine how the Sharia Marketing Analysis of the Marketing Implementation of Multibeauty Soap. Based on the theory of Sharia marketing, according to Hermawan Kertajaya and Muhammad Syakir Sula, four characteristics of Sharia marketing indicators can be used as a guide for marketers. However, not all indicators of the characteristics of Sharia marketing can be met by marketers. As happened at Alfi Store, there is an injustice in the marketing of multibeauty soap, namely the unequal cutting of soap. However, behind this problem, sales of Multibeauty soap in one-eighth pieces are increasing and attracting consumers. The results of this study indicate that: (1) The implementation of Multibeauty soap marketing based on sharia marketing analysis in general is by the theory. However, some could be more optimal. (2) The impact of implementing Multibeauty soap marketing based on the Sharia marketing analysis felt by Alfi Store, seen from an internal business perspective, explains that Multibeauty soap is by customer specifications. The economic price and a million benefits are one of the advantages of this product. The learning and growth perspective explains that business owners continue to improve their performance by regularly conducting sharing and seminars with other business partners. The customer perspective explains that consumers of Multibeauty soap feel satisfied. The financial perspective explains that consumers make repeat orders, which increases the number of sales of Multibeauty soap by one-eighth piece. (3) The factors that affect the level of sales of Multibeauty soap are affordable prices, best quality, distribution channels, and good service.
Manajemen Konflik Pada Franchise Roti Bakar Gandaria Magetan
Authors: Rendra Firmansyah  , Luhur Prasetiyo
Published: August 2023

Conflict is common in everyday life, including business. Conflicts occur between franchisors and franchisees in the Roti Bakar Gandaria Magetan franchise. Conflicts arise due to policies that need to be carried out correctly and services that are not optimal. For this reason, this study was conducted to determine how conflict management was carried out by the Roti Bakar Gandaria franchise head and its impact. The method used in this study is qualitative, with data collection techniques in the form of interviews and conservation with franchisors and franchisees who experience conflict. The data analysis technique used is a deductive analysis that departs from general to specific by looking at the theory and then colliding with actual conditions. The results of this study show that the conflict in the Gandaria Toast franchise is constructive-horizontal. The leading cause of conflict is poor communication between franchisors and franchisees. The strategies to resolve conflicts are Collaboration Strategy, Competitive Strategy (competing), and Accommodative Strategy. The impact after the franchisor issues a policy to the franchisee is the resolution of the conflict, even though the franchisee is dissatisfied because the decision issued is considered inappropriate.
Pengaruh EPS, ROE, dan ROA terhadap Harga Saham Perusahaan Consumer Goods Periode 2015-2020
Authors: Rizal Rosikin  , Maulida Nurhidayati
Published: August 2023

Prospective investors must do a financial ratio analysis to determine the best and most profitable investment decisions. In theory, the value of Earning Per Share (EPS), Return on Equity (ROE), and Return On Assets (ROA) increases and will increase stock prices. The identification results show that when the EPS, ROE, and ROA of consumer goods companies have increased EPS, ROE, ROA, and Stock Price, the stock prices of consumer goods companies have decreased. This shows that there needs to be more theory and data. Based on this, this study aims to examine and analyze the effect of EPS, ROE, and ROA on the stock price of Consumer Goods companies partially or simultaneously. This type of research is quantitative research using secondary data. There is also data collection using a documentation study. The data used in this study is in the form of annual reports of Consumer Goods companies listed on the Indonesia Stock Exchange (IDX) for the 2015-2020 period. The analytical method used is panel data regression analysis with the stages of panel data regression model estimation, panel data regression model selection, classical assumption test, and significance test; the software used is Eviews 9.0. The results of this study indicate that the EPS variable partially has a positive effect on stock prices. ROE variable partially does not affect stock prices. The ROA variable partially has a negative effect on the Stock Price. The EPS, ROE, and ROA variables simultaneously significantly affect the Stock Price. Adjusted R-squared has a value of 77.135%. This shows that EPS, ROE, and ROA in this study affect 77.135% of stock prices, while other variables outside this study influence 22.86%.
Resource-saving technology of tailings utilization of non-ferrous metals beneficiation
Authors:   Moscow Polytechnic University, GOLIK Vladimir , DEDEGKAEVA Nina ,   North Caucasian Institute of Mining and Metallurgy (State Technological University), KOZHIEV Khambi ,   North Caucasian Institute of Mining and Metallurgy (State Technological University, BELODEDOV Andrey ,   South Russian State Polytechnic University
Published: August 2023

Introduction. The article presents the results of research on the problem of waste disposal of ore processing by changing the properties of metal-containing raw materials. The research methods are based on experiments using the method of electrochemical activation of metal extraction processes. Results. The purpose of the study is formulated as modernization of the technology of extraction of metals from ores by leaching in relation to non-ferrous metals. It has been determined that the tailings of the enrichment of metal ores contain valuable metals that are not fully extracted by traditional methods of enrichment, which form compounds dangerous to the environment. It is determined that the leaching efficiency increases due to a decrease in the activated reaction area of the working solution with minerals containing the extracted metal. A mathematical description of the leaching kinetics is given depending on the surface area of the particles and the applied energy. Models for evaluating technology options and determining savings from the use of the phenomenon of mechanical activation are proposed. Discussion of the results. It is shown that a promising direction of metal extraction is combined chemical enrichment and mechanical activation with high energy in a disintegrator. It is determined that the activation of minerals in the disintegrator increases the recovery of metals by more than one and a half times, and the combination of grinding and leaching processes increases it even more. Conclusion: during the disposal of ore dressing waste, the mechanochemical activation of binders increases the extraction of metals, reducing risks to the environment.
Effect of grain size distribution of tailings during the formation of technogenic deposit on the fragmentation index
Authors:   St. Petersburg Mining University, LIGOTSKIY Dmitry , ARGIMBAEVA Kristina ,   St. Petersburg Mining University
Published: August 2023

The most important link in the process chain for creating waste-free technology at concentrating plants is to ensure the possibility of using tailings, where the bulk of non-metallic minerals, rare earth minerals or overburden is concentrated. Increasingly, mining enterprises store their waste, forming man-made deposits. Thus at present time, the development of section technogenic deposits containing tailings is becoming a pressing challenge. The characteristic feature of such deposits is the polydispersity of the developed material, which makes it difficult to determine the fragmentation index. Therefore, the objective of this paper is to study the influence of the grain size distribution of tailings on the fragmentation index during the formation of an technogenic deposit, wherein said index affects the performance of mining and transport equipment, as well as the safety of mining operations. This paper is prepared with the application of the method of mathematical analysis, as well as a laboratory method, including determination of the volume of the pore space by displacement of the liquid phase from a container with a polydisperse mixture and measuring of weight indicators. The polydisperse mixture is represented by a fraction of 0–0,2 mm, 0,2–0,8 mm, 0,8–2,0 mm, 2,0–4,0 mm. 4,0–8,0mm, 3,0–12,0mm. An analysis was made of the influence of 5 indicators on the loosening coefficient. As a result of the study, it was found that the main criterion affecting the loosening coefficient is the ratio of coarse to fine class in the mixture, and not the size of the weighted average particle in it, and the smaller this ratio, the lower the loosening coefficient approaches 1. Class 1 reception in subsequent calculations. The results obtained will become the basis for studying the loosening factor in the development of man-made deposits, represented by tailings, and require further improvement of the theoretical foundations and industrial use.
To the method of justification of borders between open and underground works
Authors:   Irkutsk National Research Technical University, MURZIN Nikolay , TALGAMER Boris ,   Irkutsk National Research Technical University, DUDINSKIY Fedor ,   Irkutsk National Research Technical University
Published: August 2023

Introduction. Currently, in the development of mineral deposits, the most widely used are open and underground methods. At the same time, open-pit mining is characterized by an extremely negative impact on the environmental situation, while at enterprises that develop deposits by underground methods, labor productivity is lower and, with some development systems, the extraction of minerals is much worse. The possibility of using open pit and underground works at one field makes it possible to use the advantages of each of the development methods, while reducing the negative factors of one of them at the expense of the other. The aim of the work is to assess the impact of technological solutions involving internal dumping on the establishment of a boundary between open pit and underground operations, taking into account the reduction of the technogenic impact on the environment. Methods for determining the boundaries of the open pit can be divided into 2 groups: the first includes methods for determining the boundaries of the open pit by the minimum total costs or the maximum total profit, the other includes methods using the boundary stripping ratio. In this work, when developing an economic-mathematical model, the methodology proposed by Professor A.I. Arsentiev, where profit is used as a criterion for the transition from open to underground work. As a result of the research, an economic-mathematical model was developed and tested to solve the problem of determining the boundary of the transition from open to underground work, based on obtaining additional profit by reducing environmental costs and taking into account the change in the order of dumping. Dependences have been obtained that reflect the change in the economically justified depth of the open pit on the degree of use of the mined-out space, as well as on the area of external dumps. The analysis of the obtained dependences shows that within the established limits and the given modeling parameters, the use of the worked-out space of the quarry allows to reduce the area of external dumps from 13 ha to 2 ha, while the boundary stripping ratio increases to 5.04, and the depth of the open pit increases from 105 m to 116 m. The results of the study can be used in the design of field development by open pit and combined methods.
Mechanical dewatering of sapropel in its small-scale mining technology
Authors:   St. Petersburg Mining University, UTENKOVA Tat'yana , KREMCHEEV Eldar ,   Academy of Natural Sciences, NAGORNOV Dmitriy ,   St. Petersburg Mining University, IVANOV Sergey ,   St. Petersburg Mining University
Published: August 2023

The article presents the results of studies on sapropel dehydration. On the territory of the Russian Federation there are about 50 thousand deposits of sapropel, which is one of the types of local raw materials for multidisciplinary use. The reason for the low profitability of sapropel extraction is due to the difficulty of removing moisture from sapropels, the humidity of which can reach 99%. The most promising for sapropel dewatering instead of traditional moisture removal technologies due to filtration and prolonged natural drying is the use of the capillary effect of a thin-porous material. Based on theoretical and experimental data, the design of the sapropel dewatering plant was developed, which allows obtaining sapropel of the required humidity in the conditions of the deposit. As a result of experimental studies, the coefficient of the relative rate of moisture loss from the contact time of sapropel and the microfiber surface was obtained, while the mass fraction of moisture in the dehydrated sapropel is in a nonlinear dependence on the contact time of raw materials with the lining of the drums. It is established that in order to achieve a humidity of 60-65%, the contact time should be at least 1.64 s. The results of the research can be useful in the creation of mining equipment for sapropel dewatering, operating in the conditions of the deposit, allowing obtaining sapropel of the required humidity.
The Polar Urals Mountain landscapes as objects of traditional nature management (According to reindeer herders surveys)
Authors:   Institute for Water and Environmental Problems, Siberian Branch, Russian Academy of Sciences, LUBENETS Lilia , CHERNYKH Dmitry ,   Altai State University, LOKTEV Rostislav ,   State Autonomous Institution of the Yamalo-Nenets Autono-mous Okrug "Scientific Center for the Study of the Arctic", KOLESNIKOV Roman ,   State Autonomous Institution of the Yamalo-Nenets Autono-mous Okrug "Scientific Center for the Study of the Arctic"
Published: August 2023

Introduction. The North is traditionally perceived as the endless plains used by reindeer herders for long-distance migrations. However, polar regions are also represented by the mountains with specific nature management. Sustainability is characteristic of historically established ways of management in the mountains based on spatial and temporal organization of landscapes adapted to local conditions at the most. The Polar Urals is the historically existing areal- the joint habitat of different peoples: the Nenets people (prevailing among indigenous peoples of the Russian North), the Khanty, and the Komi-Zyryans. At present, the Polar Urals is one of the stable centers of traditional reindeer husbandry. Climate change and “civilization” influence are challenges to traditional mountain nature management as they introduce a number of uncertainties into the existing system of interaction between the population and nature calling for local communities adaptation. Materials and methods. In this study, the method of interviewing based on the authors’ questionnaire was used. Results. The regional specifics of the mountain nature management and self-identification of reindeer herders of the Polar Urals as compared to other clans of their ethnic groups are shown. Besides pastures, water and wood (being decisive in the well-being of local communities) are among most important natural benefits provided by the Polar Urals landscapes. Conclusion. The reindeer herders of the Polar Urals try to preserve the traditional nature management through successful adaptation to modern challenges (e.g. climate change). To a large extent, they consider the introduction of novel technical achievements positively. Suggestions for practical application and direction for future research. The results of the study can be used in the preparation of regional and municipal programs to support traditional nature management in the Polar Urals, and the development of measures to adapt it to modern challenges.
Choice justification of material for the geohod blades working body manufacture
Authors:   Novgorod State University, NOZIRZODA Shodmon , EFREMENKOV Andrey ,   Novgorod State University, OGANESYAN Armine ,   National University of Science and Technology MISIS
Published: August 2023

Introduction. The use of geohods for the development of underground space is an innovative approach, the essence of which is the use of geo-media in the rock mass to create traction forces. The constructive and functional requirements for the working bodies are being developed, which take into account the nature of the movement and functionally constructive differences, the formation of a specific form of slaughter obtained during the operation of the working body, in which the working body is made in the form of helicoids shape. To implement technological solutions, it is necessary to select and justify the materials of the working body of the geohod. Materials and methods. The paper considers the basic requirements for the materials of the working body of the geohod, based on the structural, functional and technological features of the design of the geohod. The paper notes that the cutting edge of the working works in particularly harsh conditions, therefore, materials such as alloy steels with high wear resistance are recommended for this type of construction. Foundry alloy steels and high-strength alloy alloys are considered as rational options. Research results and their discussions. Taking into account the features of the equipment, the physical and mechanical properties of the rock being destroyed, the strength characteristics of the recommended materials and their technological properties, when choosing materials, emphasis is placed on the mechanical properties of materials and wear-resistant properties, which are important parameters, since abrasive wear of the working surfaces occurs when the working body of the geohod. Conclusion. The recommended alloyed alloys with high strength meet all the requirements that are imposed on the design of the knife of the executive body, but do not meet the technological requirements, namely, they are quite difficult to deform, difficult to process by cutting and welded. Considering all the technological properties that are significant in the implementation of the manufacturing technology of the working body of the geohod, it is recommended to choose more durable materials that withstand large continuous loads. Resume. The article presents the results of research to determine the choice of material for the manufacture of the working body of the geohod. It is established that for the manufacture of the working body, when using the casting technology of production, steel 30ХГСА can be used, when processing pressures – steel 18Х2Н4МА. Suggestions for practical application and direction of future research may be useful for the development of manufacturing technology of the main elements of the working body of the geohod.
The dilemma of the split between theory and reality as experienced by primary health care professionals: a mixed methods study of evidence- based practice in a primary care context
Authors: Abelsson Tobias , Karlsson Ann-Kristin , Morténius Helena , Baigi Amir , Bergman Stefan
Published: August 2023

Background: Previous research has focused mainly on Evidence-based Practice (EBP) within specific professions. Primary care depends upon good information flow across professional and structural boundaries to best care for the patients. The mapping of the pan-professional experiences and attitudes regarding EBP in publicly funded clinical practice is necessary to reach an understanding of EBP and its context of implementation. Thus, this study aimed to investigate healthcare professionals’ experiences and attitudes toward working according to EBP in primary care.
Methods: The study used a convergent mixed methods design divided into two strands: First consisting of a quantitative enquiry tool (Evidence-Based Practice Attitude Scale, EBPAS). The second is a set of qualitative interviews analysed using qualitative content analysis. Both strands included all employees with patient interaction in the studied county (n=625). Population included amongst others, doctors, nurses, physiotherapists, psychologists, and assistant nurses. Out of the original 625 health professionals included, 191 finished the first strand and 8 volunteered for the second strand (2 nurses, 2 physiotherapists, 1 psychiatrist and 3 doctors).
Results: The EBPAS value of 2.8 (max 4) indicated a generally positive attitude towards EBP amongst the population. This attitude could be seen also in interviews, with the addition of experiences of not having the ability or resources to engage in EBP. This was illustrated by the result from the qualitative content analysis resulting theme: “Dilemma of the split between theory and reality”.
Conclusions: Although the general attitude towards EBP is good, experiences of practising it differ. There is a need to increase knowledge of concepts, requirements, and execution of EBP. There were few or non-existent incentives towards educational or research development on an individual level due to the organizational and managerial focus on production rather than quality of care. The absence of opportunities to do research and collegial debate about new ways of finding and implementing research-based evidence results might influence the quality of care.
Incipient carbonate melting drives metal and sulfur mobilization in the mantle
Authors: Ezad Isra , Saunders Martin , Scheka Syatoslav , Fiorentini Marco , Gorojovsky Lauren , Foerster Michael , Foley Stephen
Published: August 2023

We present results from high-pressure, high-temperature experiments that generate incipient carbonate melts at mantle conditions (~ 90 km depth and temperatures between 900–1050°C). We show that these primitive carbonate melts can sequester sulfur in its oxidized form of sulfate, as well as base and precious metals from mantle lithologies of peridotite and pyroxenite. It is proposed that these carbonate-sulfur-rich melts may be more widespread than previously thought, and that they may play a first order role in the metallogenic enhancement of localized lithospheric domains. They act as effective agents to dissolve, redistribute and concentrate metals within discrete domains of the mantle and into shallower regions within the Earth, where dynamic physico-chemical processes can lead to ore genesis at various crustal depths. Green metals could be transported and concentrated into ores by their interaction with low temperature carbonate rich melts.
Effect of an entry-to-care intervention on diabetes distress in individuals with newly diagnosed type 2 diabetes: A study protocol for a cluster-randomized trial.
Authors: Hansen Steffan Holst , Jensen Troels Mygind , Petersen Gitte Stentebjerg , Pouwer Francois , Sonderlund' Anders Larrabee , Søndergaard Jens
Published: August 2023

Background
Diabetes distress (DD) affects at least 36% of T2DM patients and is often associated with insufficient support and care. This study examines an intervention that targets DD through enhanced cross-sectoral collaboration and treatment during the first three months following diagnosis. The intervention aims to improve care, self-management, and to reduce DD.
Methods & Intervention
The study is designed as a cluster-randomized trial with the intervention focusing on four key elements of diabetes care: effective cross-sectoral communication and information sharing, systematic care, a "one-stop-shop" health screening and start-up conversation at the municipality, and improving patient insights into own care.
This study requires 32 clusters (16/arm) to achieve 80% power and a 5% significance cut-off, with 270 patients required. GP recruitment occurred from May-Dec 2022. Patient recruitment is ongoing from May 2022 to Aug 2023. GPs were randomized 1:1 using computer-generated blocks of six.
Participating GPs are located in Southern Denmark and are not participating in other trials. Patients must be 18+ years of age, have a T2DM diagnosis, and be fluent in spoken and written Danish. DD is the primary outcome and will be measured at baseline, at four months, and again at 12-month follow-up. Secondary outcomes include quality of care, self-management, quality of life, and clinical factors. Tertiary outcomes comprise depression, stress, resilience, sleep quality, and social network quality.
Conclusion
This study is among the first clinical trials exploring the development of DD from diagnosis to 12 months post-diagnosis. Many previous interventions did not directly target DD as the primary outcome. This research provides new insights into DD progression in patients newly diagnosed T2DM and examines an intervention designed to lower DD in early diabetes stages, contributing to a better understanding of the development of DD how this intervention affects patient well-being.
Trial registration: ClinicalTrial.gov, NCT05571306. Registered 07 October 2022, https://beta.clinicaltrials.gov/study/NCT05571306
Nodal superconductivity in miassite Rh17S15
Authors: Prozorov Ruslan , Kim Hyunsoo , Tanatar Makariy , Konczykowski Marcin , Kaluarachchi Udhara , Cho Kyuil , Sapkota Aashish , Wilde John , Krogstad Matthew , Bud'ko Sergey , Brydon Philip , Canfield Paul , Teknowijoyo Serafim
Published: August 2023

Unconventional superconductivity has long been believed to arise from a lab-grown correlated electronic system. Here we report compelling evidence of unconventional nodal superconductivity in a mineral superconductor Rh17S15. We investigated the temperature-dependent London penetration depth Δλ(T) and disorder evolution of the critical temperature Tc and upper critical field Hc2(T) in synthetic miassite Rh17S15. We found a power-law behavior of Tn with n≈1.1 at low temperatures below 0.3Tc (Tc = 5.4 K), which is consistent with the presence of lines of the node in the superconducting gap of Rh17S15. The nodal character of the superconducting state in Rh17S15 was supported by the observed pairbreaking effect in Tc and Hc2(T) in samples with the controlled disorder that was introduced by low-temperature electron irradiation. We propose a nodal sign-changing superconducting gap in the A1g irreducible representation, which preserves the cubic symmetry of the crystal and is in excellent agreement with the superfluid density, λ2(0)/λ2(T).
Eco-friendly Orange Peel Extract as Corrosion Resistant for Carbon Steel's Deterioration in Petroleum Formation Water
Authors: Elazabawy Olfat E. , Attia Enass M. , Shawky N. H. , Hyba Amira M.
Published: August 2023

The ongoing research aims to examine the influence of orange peel extract "OPE" as environmentally benign carbon steel's corrosion resistance in the formation water "FW". The research was implemented at various concentrations "0.5-2.5 percent (v/v)" of peel extract "100-500 ppm" at ambient temperature [25oC] as well as "2.5 percent (v/v)" concentration at (25-55oC) temperature range utilizing various technique. Such techniques include weight loss quantification, potentiodynamic polarization as well as open circuit potential in addition to dielectric spectroscopy [EIS]. The efficiency of inhibition has been estimated utilizing those techniques and then checked with energy dispersive radiation "EDS" in addition to FTIR analyses. The upshot divulged that OPE worked on as an efficient C-steel's corrosion inhibitor through adsorbing its active component on the C-steel's surface. The approach of adsorption was of physical type and it obeys Langmuir isotherm.
Environmental Risk Factors and Plasma Concentration of Lead and Copper in Colorectal Cancer Patients in Alexandria, Egypt: A case-control study
Authors: Mohamed Soha Said , Moustafa Mohamed Farouk , Abdou Mamdouh Hanafy , Hussien Fakhry
Published: August 2023

Background:Colorectal canceris the third most commonly diagnosed cancer in both men and women. It is thought to result from a complex interaction between several genetic and environmental factors. Recognizing these factors that trigger the disease occurrence and progression is essential to apply more effective measures of prevention and risk reduction.Objectives:The main objectives of this study were to compare the plasma levels of lead and copper in colorectal cancer between patients and healthy subjects and to estimate the relation between the exposure to some environmental risk factors and colorectal cancer.Methods:A case-control study was performed at the clinical oncology department clinic of Alexandria Main University Hospital. The study sample consisted of 25 colorectal cancer patients, and 25 healthy controls, who matched the cases on age and sex. Data about possible environmental risk factors were collected by a pre-designed structured interviewing questionnaire. Levels of lead (Pb) and copper (Cu) of all participants were measured by graphite furnace atomic absorption spectrometry.Results:Higher levels of Pb and Cu were detected in colorectal cancer patients compared to healthy subjects, these findings were statistically significant (p<0.05). The multivariate stepwise logistic regression model revealed that four factors had significant association with colorectal cancer, the first rank was Living nearby solid waste collecting sites, followed by exposure to environmental tobacco smoke (ETS), then plasma Lead level (>0.164 mg /L), and lastly living in house with old oily painting(OR = 83.25, 95% CI = 1.28-5419.13; OR = 32.20, 95% CI = 1.53-678.07; OR = 31.06, 95% CI = 1.55-622.59; OR = 9.35, 95% CI = 1.02-85.79, respectively).Conclusion:There was a significant difference in the plasma levels of Pb and Cu between colorectal cancer patients and healthy subjects. This may be due to prolonged exposure to environmental pollutants. Chronic exposure to environmental pollutants may have important role in the pathogenesis of the colorectal cancer. However, further studies are needed to enhance our understanding of this relationship between heavy metals and their role in cancer progression.
Verbal Lie Detection using Large Language Models
Authors: Loconte Riccardo , Russo Roberto , Capuozzo Pasquale , Pietrini Pietro , Sartori Giuseppe
Published: August 2023

Given that human accuracy in detecting deception has been proven to not go above the chance level, several automatized verbal lie detection techniques employing Machine Learning and Transformer models have been developed to reach higher levels of accuracy. This study is the first to explore the performance of a Large Language Model, FLAN-T5 (small and base sizes), in a lie-detection classification task in three English-language datasets encompassing personal opinions, autobiographical memories, and future intentions. After performing stylometric analysis to describe linguistic differences in the three datasets, we tested the small- and base-sized FLAN-T5 in three Scenarios using 10-fold cross-validation: one with train and test set coming from the same single dataset, one with train set coming from two datasets and the test set coming from the third remaining dataset, one with train and test set coming from all the three datasets. We reached state-of-the-art results in Scenarios 1 and 3, outperforming previous benchmarks. The results revealed also that model performance depended on model size, with larger models exhibiting higher performance.Furthermore, stylometric analysis was performed to carry out explainability analysis, finding that linguistic features associated with the Cognitive Load framework may influence the model’s predictions.
Furthermore, stylometric analysis was performed to carry out explainability analysis, finding that linguistic features associated with the Cognitive Load framework may influence the model’s predictions.
Influence of fluoride addition as a filler in a based zinc ethyl silicate shop primer on FCAW welds produced over coated plates
Authors: de Rezende Leonardo Schiavo , Verde Lorena Arco , Vaz Cláudio Turani
Published: August 2023

Structural steels that require coating with pre-construction paints to avoid corrosion are utilized in important industrial segments. These paints, known as primers, act as corrosion inhibitors; however, they can have a detrimental impact on welding performance and compromise the quality of welds. In order to overcome these challenges, new alternatives need to be developed to achieve welds that are, at the very least, equivalent to those obtained on uncoated plates. To this end, this work aim at promoting the production of welds on plates coated with primer and varying concentrations of fluoride added to the base formulation, by means of 1.2mm diameter tubular wire classified as E71T1-C1A2-CS2 with CO2 gas protection. In a comparative analysis, the influence of non-filler primer and primer with 7.5% and 15% by mass of lithium fluoride was examined. It was found that the primer inhibits the adhesion of welding spatter on the plates, affecting the weld morphology and resulting in wider and deeper weld beads. On the other hand, the presence of fluoride tends to reduce the weld width, although it does not appear to affect penetration. It was also observed that the primer does not influence the weld microstructure, as opposed to welds with no primer. The incorporation of fluoride filler increases the volumetric fraction of acicular ferrite and aligned second-phase ferrite, while simultaneously reducing the fractions of primary ferrite at the grain boundary and of intragranular ferrite. Lastly, the electrical signals recorded during welding show that the primer increases the average welding voltage, and the presence of fluoride tends to mitigate this effect. On the other hand, the average current tends to decrease in the presence of the primer, and the addition of fluoride exacerbates the trend. As a consequence, samples with fluoride filler exhibit lower thermal inputs compared to the other samples. Furthermore, the presence of the primer leads to an increased frequency of voltage peaks, indicating alterations in the metal transfer process.
Predictive effect of the systemic inflammation response index (SIRI) on the efficacy and prognosis of neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer
Authors: Ding Yuanyi , Liu Zining , Li Jing , Niu Wenbo , Li Chenhui , Yu Bin
Published: August 2023

Background
Inflammation is a part of tumors, in which inflammatory cells can affect the proliferation, invasion, and development of tumor cells. More and more An increasing number of peripheral blood inflammatory markers have been found to play very important roles in the treatment and prognosis of cancer patients. The systemic inflammation response index (SIRI) is a newer inflammatory marker, and its role in colorectal cancer, especially in locally advanced rectal cancer, is still unclear.
Methods
From 2015 to 2020, 198 patients with locally advanced rectal cancer (LARC) who underwent surgery following neoadjuvant chemoradiotherapy (Neo-CRT) were analyzed. Patients were categorized into good and poor response groups according to their pathological results, and clinical characteristics and baseline parameters were compared between the two groups. The optimal cutoff values of inflammatory indicators were determined using receiver operating characteristic (ROC) analysis. Univariate analysis and multivariate analysis were performed using the Cox proportional hazard model. Survival analysis was calculated by the Kaplan‒Meier method.
Result
After the patients were grouped by good and poor responses, it was found that there were differences among the four indicators of CEA, neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), and SIRI. In the ROC analysis, the NLR (P = 0.015), SII (P = 0.001), and SIRI (P = 0.029) were found to be significant prognostic factors. After univariate and multivariate analyses of the Cox proportional hazards regression model, only SIRI was found to be an independent prognostic factor for overall survival (OS) and disease-free survival (DFS). Finally, the Kaplan‒Meier survival curve also confirmed the predictive effect of SIRI on survival.
Conclusion
Preoperative SIRI can predict the response to Neo-CRT in patients with LARC and is an independent predictor of OS and DFS in postoperative patients. High SIRI was associated with poor radiotherapy response and predicted poor OS and DFS.
A review and content analysis of hemophilia applications: Mobile Application Rating Scale (MARS) Approach
Authors: Esmaeeli Erfan , Ataee Elham , Sajjadi Hasan , Mohammadzadeh Niloofar
Published: August 2023

Background
Mobile health technology has the potential to break down conventional boundaries in the healthcare industry by providing healthcare in any environment, reducing distance, time, and cost, and bringing comfort and peace to patients. Despite the increasing availability of mobile health applications for hemophilia management, no study has yet used a valid tool to evaluate these applications. Therefore, the aim of this study was to evaluate the quality and content of hemophilia-related mobile applications using the Mobile App Rating Scale (MARS) scale.
Methods
In March 2023, two app stores, namely, the Apple App Store (iOS) and Google Play (Android), were searched for applications related to hemophilia self-care. Based on MeSH terms, the search keywords used included "hemophilia", "haemophilia", "hemophilia A", and "hemophilia B". The inclusion criteria included applications developed for hemophilia sufferers, being related to hemophilia, being in the English language, being free, and being available in the mentioned app stores. After determining the final number of applications based on the inclusion and exclusion criteria, they were independently reviewed, rated, and evaluated by three reviewers using the MARS tools.
Results
A total of 69 applications were initially found, with 30 from Google Play and 39 from the Apple App Store. Following the exclusion process, seven selected applications were downloaded and analyzed. Based on their contents and interactive capabilities, all applications were divided into three groups. In the domains of engagement, functionality, aesthetics, information, and app subjective quality, MicroHealth Hemophilia and Robust Health (5 out of 5), my WAPPS and HaemActive and MicroHealth Hemophilia and Robust Health (4.75 out of 5), Robust Health (5 out of 5), my WAPPS (4.28 out of 5), and my WAPPS (5 out of 5) applications received the highest points, respectively.
Conclusions
This study compiled a list of seven mobile applications intended to improve access to hemophilia-related information, patient care management, teleconsultation, and self-assessment. The findings indicate that very few applications meet the prespecified criteria for quality, content, or functionality. This highlights the need for further refinement and mapping to evidence-based guidelines, as well as overall quality improvement in hemophilia symptom monitoring and self-care-related applications.
LanDis: The Disease Landscape Explorer
Authors: Paccanaro Alberto , Caniza Horacio , Cáceres Juan , Torres Mateo
Published: August 2023

From a network medicine perspective, a disease is the consequence of perturbations on the interactome. These perturbations tend to appear in a specific neighbourhood on the interactome, the disease module, and modules related to phenotypically similar diseases tend to be located in close-by regions.
We present LanDis, a freely available web-based interactive tool (paccanarolab.org/landis) that allows domain experts, medical doctors and the larger scientific community to graphically navigate the interactome distances between the modules of over 44 million pairs of heritable diseases. The map-like interface provides detailed comparisons between pairs of diseases together with supporting evidence. Every disease in LanDis is linked to relevant entries in OMIM and UniProt, providing a starting point for in-depth analysis and an opportunity for novel insight into the aetiology of diseases as well as differential diagnosis.
HNL Dimer in plasma is a unique and useful biomarker for the monitoring of antibiotic treatment in sepsis
Authors: Venge Per , Peterson Christer , Xu Shengyuan , Larsson Anders , Johansson Joakim , Tydén Jonas
Published: August 2023

Sepsis is a growing problem worldwide and associated with high mortality and morbidity. The early and accurate diagnosis and effective supportive therapy are critical for combating mortality. The aim of the study was to compare the kinetics of four biomarkers in plasma in patients admitted to ICU including sepsis and during antibiotics treatment. Methods The biomarkers evaluated were HBP (Heparin-binding protein), HNL Dimer (Human Neutrophil Lipocalin), HNL Total and PCT (Procalcitonin). Plasma was obtained at admission to ICU and during follow-up at days 2 and 3. Antibiotic treatment was started or reviewed on admission to ICU. The results were compared to SOFA and KDIGO-scores and to survival. 277 patients admitted to ICU were included of which 30% had sepsis. The other groups were categorized as miscellaneous, other medical and trauma. Results The plasma concentrations of all four biomarkers were highly elevated with the highest concentrations in sepsis patients. During the follow-up period HNL Dimer decreased already day 2 and further so day 3 (p < 0.00001) in contrast to unchanged concentrations of the other three biomarkers. HNL Total showed the strongest relationships to the clinical scores (p < 0.0001) and was by multiples regression analysis independently related to these scores. Conclusion The neutrophil specific biomarker HNL Dimer seems to be a superior means to monitor the response to antibiotic treatment in ICU patients and confirms earlier findings of a rapid decline after adequate antibiotic treatment in sepsis. HNL Total reflects epithelial cell activity in the body and is an interesting biomarker for the management of organ failure in such patients.
Associated Factors of Diabetic Retinopathy by Artificial Intelligence Evaluation of Fundus Images in Japan
Authors: Komatsu Koji , Sano Kei , Fukai Kota , Nakagawa Ryo , Nakagawa Takashi , Tatemichi Masayuki , Nakano Tadashi
Published: August 2023

This cross-sectional study aimed to investigate the promoting and inhibitory factors of diabetic retinopathy (DR) according to diabetes mellitus (DM) stage using standardized evaluation of fundus images by artificial intelligence (AI). A total of 30,167 participants underwent blood and fundus examinations at a health screening facility in Japan (2015–2016). Fundus photographs were screened by the AI software, RetCAD and DR scores (DRSs) were quantified. The presence of DR was determined by setting two cut-off values prioritizing sensitivity or specificity. DM was defined as four stages (no DM: DM0; advanced DM: DM3) based on treatment history and hemoglobin A1c (HbA1c) levels. Associated factors of DR were identified using logistic regression analysis. For cutoff values, multivariate analysis revealed age, sex, systolic blood pressure (SBP), smoking, urinary protein, and HbA1c level as positively associated with the risk of DR among all DM stages. In addition to glycemic control, SBP and Fib-4 might act as promoting factors for DR at all or an earlier DM stage. T-Bil, cholinesterase, and T-cho level might be protective factors at an advanced DM stage.
Psychometric Assessment of the 10-item Experience of Close Relationship- Revised for Adolescents (ECR-R-10-AD)
Authors: Wongpakaran Tinakon , DeMaranville Justin , Wongpakaran Nahathai , Wedding Danny
Published: August 2023

Background:
The Experiences of Close Relationships-revised (ECR-R) is a widely used 36-item self-report measurement for measuring adult as well as child and adolescent attachment. However, some short versions of the ECR-R have been developed and tested psychometrically. Due to cultural differences, respondents from different cultural backgrounds may respond differently to specific items of the ECR-R. This study aimed to develop a new, shorter version of the Thai version of 18-item ECR-R used in Thai adolescents to make it feasible to use and to improve psychometric properties.
Methods:
This study included 433 adolescents, aged between 13-17 years old. Participants completed the 18-item ECR-R, Rosenberg Self-Esteem Scale, Perceived Stress Scale, and Relationship Questionnaire. Exploratory factor analysis was performed to determine the suitable number of items for a new scale. A correlation between the ECR-R-18 and the new scale was carried out. Additionally, correlations between the ECR-R-18, the new scale, and other measurements were also analyzed. The Cronbach alphas and corrected correlations between the anxiety and avoidance subscales of the old and new ECR-R were calculated. Confirmatory factor analysis of the first-order two-factor solution model with fit statistics was examined. Multigroup CFA was performed to investigate measurement invariance.
Results:
he new scale with 10 items, called “ECR-R-10-AD” was developed with good Cronbach’s alpha values of 0.859 and 0.824 for avoidance and anxiety subscale, respectively. The corrected correlation between the ECR-R-18 and ECR-R-10-AD was between .76 (p < .001) and .78 (p < .001). The data fitted the first order two factor solution model well indicating by the values of the comparative fit index (0.968) and Tucker-Lewis index 0.957) for the model, whereas the root-mean-square error of approximation was 0.063 (90%CI, 0.048-0.079), and standardized root mean square residual was 0.046, indicating that the model fits were excellent. The ECR-R-10-AD was shown to have convergent validity with other measurements. The ECR-R-AD seemed to be superior to the ECR-R-18 regarding criterion validity. Measurement invariance was successfully established across different sexes.
Conclusion:
The ECR-R-10-AD provided sufficient psychometric properties among Thai adolescents. Factorial validity, convergent validity and measurement invariance were established. As the ECR-R-10-AD is brief, it can be administered with less burden. Limitation and future research were discussed.
Distribution of bla OXA-10 , bla PER-1 , and bla SHV genes in ESBL-producing Pseudomonas aeruginosa strains isolated from burn patients
Authors: Polse Reem Foad , Khalid Haval M. , Mero Wijdan M. S.
Published: August 2023

Pseudomonas aeruginosa is resistant to a wide range of extended spectrum-lactamases (ESBLs) antibiotics because it produces several kinds of ESBLs. The goal of the current investigation was to identify the bacteria that produce extended spectrum -lactamases and the genes that encode three different ESBLs, such as blaOXA−10, blaPER−1 and blaSHV genes in Pseudomonas aeruginosa isolated from burn patients. In this investigation, 71 Pseudomonas aeruginosa isolates were isolated from burn wounds in Burn and Plastic Surgery Hospital, Duhok City between July 2021 to June 2022. For the purpose of finding the blaOXA−10, blaPER−1, and blaSHV ESBL expressing genes, Polymerase Chain Reaction (PCR) was used. Among 71 Pseudomonas aeruginosa isolates, 26.36% (29/71) were isolated from males and 38.18% (42/71) from females, and 76.06% (54/71) of the isolates were multidrug resistant. They exhibited higher resistance against Piperacillin with resistance rates of 98.59%. Among the ESBL-producing isolates tested, blaOXA−10 was found in 59.26% (32), blaPER−1 was found in 44.44% (24), and blaSHV was found in 11.11% (6). All isolates must undergo antimicrobial susceptibility testing because only a few numbers of the available antibiotics are effective for the treatment of this bacterium. This will prevent the development of resistance in burn units and aids in the management of the treatment plan.