bluuebunny/crossref_metadata_2025 huggingface dataset:
Attitudes of preschool teachers, primary school teachers,secondary school teachers, and associates towards children of (ex) prisoners and their needs
Authors: Romstein Ksenija
Published: January 2022

It is estimated that in Croatia 12 000 - 15 000 children aged 0 to 18 have one or both parents in prison. When taking ex-prisoners into account, that number is even higher. While the prison system, in cooperation with NGOs, has made big steps towards supporting family ties
through children friendly visiting areas, adjusted protocols of child's
entrance in the prison, and programs for strengthening parental competencies of prisoners, the education system has not made significant
steps in recognizing the needs of children of (ex) prisoners. The results of this research showed that educational professionals assess peer support as a major need of children of (ex) prisoners, alongside successful school graduation. Structurally, the attitudes of educational
professionals are characterized with disparity and confusion. Educational professionals emphasize a child's close monitoring and observation for timely recognition of misconduct. Close monitoring, the expectation of misconduct, and high demands regarding a child's academic
achievement are congruent with the biological determinism paradigm. The
obtained results can be used for further research on this issue, and for designing lifelong learning programs for educational professionals about adequate strategies for supporting children of (ex) prisoners, and
for (ex) prisoners, as parents.
Consumption analysis of youtube’s entertaining and educational content from fifth to the eighth class of primary school
Authors: Kimer Karlo
Published: January 2022

The goal of this paper is to examine YouTube’s consumption frequency, its educational and entertaining content, its content creators YouTubers
and to analyze the relation of consumption frequency between educational and entertaining content on a sample of 100 students from fifth to the eighth class of primary school (46 girls and 54 boys). The study was conducted with the constructed questionnaire, which was divided into four categories: sociodemographic features, consumption frequency of educational and entertaining content, everyday habits during YouTube’s usage, and popularity of educational and entertaining channels, YouTubers. During data analysis descriptive statistics was used and ANOVA and T-test for independent samples for significant differences. Results have shown that students are on average spending more time on YouTube (M=3, 23) than on television (M=2, 67) where daily consumption increases with every higher class. Smartphones are being used as the main platform for YouTube’s usage for the majority of students, precisely said for 72 students. Results have also shown that entertaining contents (M=2.79) are more used than educational content (M=2.18) where music content (M=3.88), funny videos (M=3.38), and gaming
videos (M=3.19) are being most used. The strongest statistical differences between girls and boys have been found in gaming content (p<.001), to the boys’ favour, and in beauty and style content (p<.001), to the girls’ favour. Furthermore, results have shown that the average majority of students (M=2.93) are precisely choosing which videos are they going to watch, with the taken fact that the majority of
students are watching videos from subscribed channels. In the end, entertaining channels (M=2.51) are more popular than educational channels (M=1.39). On the results’ basis, it is now possible to conduct further research and findings of didactic-methodical values of YouTube as a teaching tool, mainly thinking on its entertaining content, with the goal to upgrade and enhance education praxis and to promote a teacher as self-reflexive and adaptable, freely said, explorer in his dynamic, ever-changing and challenging work.
Aplikasi Metode Tasmi' Dan Muraja'ah Dalam Program Tahfidzul Quran Pada Santriwati di Ma'had Tahfidz Hidayatul Qur'an Desa Puding Besar
Authors: Hendrawati Wiwik , Rosidi Rosidi , Sumar Sumar
Published: January 2022

Penelitian ini bertujuan untuk mengetahui penerapan metode tasmi’ dan muraja’ah dalam program tahfidzul Qur’an pada santriwati di Ma’had Tahfidz Hidayatul Qur’an Desa Puding Besar dan untuk mengetahui keberhasilan program tahfidzul qur’an dengan menggunakan metode tasmi’ dan muraja’ah pada santriwati di Ma’had Tahfidz Hidayatul Qur’an Desa Puding Besar. Metode penelitian ialah kualitatif deskriptif, sedangkan sumber data yang digunakan ada dua sumber yaitu, data primer dan sekunder. Tekhnik pengumpulan data dalam penelitian dilakukan melalui observasi, wawancara, dan dokumentasi. Penerapan metode tasmi’ di Ma’had Tahfidz Hidayatul Qur’an Desa Puding Besar berhasil diterapkan. Hal ini dapat dilihat dari banyaknya santriwati yang hafal dan mencapai target yang ditentukan, bahkan ada yang melebihi pencapaian target. Begitu pula dengan metode muraja’ah santriwati mampu mentasmi’kan kembali hafalan muraja’ah baik kepada ustadzah pembimbing atau ustadzah penguji ujian tahfidz. Hal ini terbukti dari hasil yang diperoleh santriwati dengan kategori penilaian mumtaz (kesalahan 0-1), jayyid jiddan (kesalahan 2-4), jayyid (kesalahan 5-7), maqbul (kesalahan 8-10), rasib (kesalahan lebih dari sepeluh), dari kelima penilaian tersebut kebanyakan santriwati mendapatkan nilai jayyid jiddan, jayyid, dan mumtaz.

This study aims to determine the application of the tasmi 'and muraja'ah methods in the tahfidzul Qur'an program for female students in Ma'had Tahfidz Hidayatul Qur'an Puding Besar Village and to determine the success of the tahfidzul qur'an program using the tasmi' and muraja 'methods ah to the students at Ma'had Tahfidz Hidayatul Qur'an, Puding Besar Village. The approach used in this research is descriptive qualitative, while the sources of data used are two sources, namely, primary and secondary data. Data collection techniques in research carried out through observation, interviews, and documentation. The application of the tasmi method in Ma'had Tahfidz Hidayatul Qur’an of Puding Besar Village was successfully implemented. This can be seen from the number of female students who memorized and reached the specified target, some even exceeded the target achievement. Similarly, the method of muraja'ah santriwati was able to eradicate the memorization of muraja'ah both to the cleric or the cleric examiner tahfidz. This is evident from the results obtained by female students in the category of mumtaz (error 0-1), jayyid jiddan (error 2-4), jayyid (error 5-7), maqbul (error 8-10), rasib (error more than ten) ), from the five assessments, most students received jayyid jiddan, jayyid, and mumtaz.
Analisis Kesulitan Siswa Dalam Menyelesaikan Soal Sistem Persamaan Linear Dua Variabel Pada Kelas VIII
Authors: Kolo Florensia , Nahak Selestina , Fitriani Fitriani
Published: January 2022

Tujuan dari penelitian ini adalah untuk mengetahui kesulitan yang dialami siswa dalam menyelesaikan soal sistem persamaan linear dua variabel dan untuk mengetahui faktor - faktor yang menyebabkan siswa kesulitan dalam menyelesaikan soal sistem persamaan linear dua variabel pada kelas VIII SMP Negeri Satap Amol. Metode penelitian yang digunakan adalah deskriptif kualitatif. Subjek penelitian ini adalah siswa kelas VIII A SMP Negeri Satap Amol yang berjumlah 3 orang. Teknik pengumpulan data yang digunakan adalah tes dan wawancara. Instrumen dalam penelitian ini adalah peneliti, soal tes, pedoman wawancara dan dokumentasi. Teknik analisis data dalam penelitian ini adalah mereduksi data, pemaparan data dan menarik kesimpulan. Berdasarkan hasil penelitian, kesulitan yang dialami siswa yaitu kesulitan konsep, kesulitan prinsip dan kesulitan menyelesaikan masalah verbal. Faktor – faktor yang menyebabkan siswa mengalami kesulitan yaitu siswa buru – buru dalam mengerjakan soal, siswa malu bertanya, catatan siswa kurang lengkap, siswa tidak belajar, siswa mengalami kekeliruan dalam mengerjakan soal,siswa tidak memahami dan mengerti, siswa kurang teliti dalam mengerjakan soal,siswa tidak membaca yang diperintahkan pada soal, siswa tidak tau apa yang diketahui dan ditanyakan pada soal.
Consumer Purchasing Decisions of Teh Pucuk Harum : Product Quality, Advertising and Brand Image
Authors:   Pelita Bangsa University, Bintarti Surya , Suwandy Suwandy ,   Pelita Bangsa University
Published: January 2022

Teh Harum Pucuk drink is one of the ready-to-drink tea drinks that are packed with great experience from previous years, so that they can compete with other packaged ready-to-drink tea drinks. Fans of ready-to-drink tea packages come from various circles, including students, workers, the general public, and college students. This review plans to examine the impact of the quality of goods, publications and brands in general on the Purchasing Decision of fragrant shoots tea products. The testing technique used is non-likelihood inspecting, specifically the purposive testing strategy. The examples in this review are 75 individuals, especially individuals who have purchased ready-to-drink tea drinks that are bundled with the brand of Teh Pucuk Wangi and information is collected by distributing Google from polls, the information collected is tested for validity with legitimacy and steadfast quality tests, information investigation procedures using the PLS program. The results of a helpless exploration show that the quality of goods and publicity factors in ready-to-drink foods bundled with teh pucuk wangi has a positive effect on purchasing choices, and brand image has a negative effect on purchasing choices of pucuk harum
Pandemik COVID-19: Isu Penggunaan ICT Dalam Proses Pengajaran dan Pembelajaran (PdP) Bagi Pelajar Orang Kurang Upaya (OKU) di Institusi Pendidikan Khas di Malaysia
Authors: Rahman Azman Ab Rahman , Nurul Nadia Nozlan  , Hussein ‘Azeemi Abdullah Thaidi  , Muhammad Firdaus Ab Rahman  , Mohamad Anwar Zakaria
Published: January 2022

Penggunaan Teknologi Maklumat dan Komunikasi (ICT) pada masa kini semakin mendapat tempat di setiap sektor di Malaysia. Kepesatan pembangunan telah menjadikan ICT itu satu keperluan dalam kalangan orang ramai. Masyarakat tidak kira golongan normal mahupun Orang Kurang Upaya (OKU) tidak ketinggalan dalam menggunakan perkhidmatan ICT yang kian meluas ini. Masyarakat lebih cenderung untuk menggunakan perkhidmatan ICT seperti internet, melakukan transaksi jual beli atas talian (online), melakukan kerja dari rumah (Work From Home) dan proses pembelajaran dari rumah sewaktu PdP. Arahan perintah kawalan pergerakan (PKP) yang telah dilaksanakan oleh kerajaan telah menyebabkan keterbatasan dalam sektor pendidikan untuk beroperasi secara biasa (bersemuka) dan menjadikan pembelajaran secara dalam talian sebagai medium gantian. Namun begitu, timbul persoalan tentang bagaimanakah golongan OKU ini menggunakan medium pengantaraan ICT atau kaedah PdP secara dalam talian sewaktu COVID-19 untuk meneruskan sesi pembelajaran mereka. Justeru, objektif kajian ini adalah untuk mengenalpasti isu yang dihadapi oleh golongan OKU dan institusi pendidikan dalam menggunakan kaedah PdP secara maya dalam proses PdP sewaktu COVID-19. Kajian kualitatif ini akan menggunakan kaedah dokumentasi, temu bual dan pemerhatian dalam mencapai objektif yang ditetapkan. Hasil kajian mendapati bahawa isu utama yang perlu ditempuhi oleh golongan OKU adalah komitmen daripada para pelajar sendiri serta komitmen ibu bapa dalam memantau pembelajaran anak istimewa mereka.  Manakala, cabaran yang dihadapi oleh sesebuah institusi pendidikan adalah untuk mengenal pasti kaedah yang sesuai bagi melaksanakan PdP secara dalam talian sewaktu COVID-19 terhadap pelajar daripada golongan OKU. Kajian ini diharapkan dapat menjadi rujukan kepada institusi pendidikan dalam menambah baik proses PdP bagi pelajar OKU sewaktu bencana berlaku seperti COVID-19 ini.
Evaluation of α-Amylase Inhibitory, Antioxidant and Cytotoxic Activities of Mimusops elengi Seeds
Authors: Mamun Al , Easmin Sabina , Ahmed Ashru , Ansary Md Rezaul Haque , Bary Wasim , Zaman Md Shahed , Haq Hamidul
Published: January 2022

Mimusops elengi Linn., locally known as “Bakul, is a commonly used medicinal plant in Bangladesh to treat several maladities. The purpose of this study was to investigate the antioxidant, α-amylase inhibitory and cytotoxic activity of four different solvent fractions such as petroleum ether, chloroform, ethyl acetate, and water of M. elengi seed. In this study, the high ferric reducing (1.74 ± 0.005) and DPPH free radical scavenging activity (IC50 39.49 ± 0.05 μg/ml) was observed in the ethyl acetate fraction. The highest amount of flavonoid content (1059.80 ± 2.15 mg of CE/g) and total antioxidant capacity (0.17 ± 0.005) was present in chloroform fraction. On the other hand, the ethyl acetate fraction exhibited the highest total phenolic content (182.90 ± 0.38 mg of GAE/g). Crude methanolic extract showed highest inhibition of α-amylase with IC50 value of 4.09 ± 0.08 mg/ml. The brine shrimp lethality bioassay of ethyl acetate fraction exhibited maximum toxicity with low LD50 value 127.10 μg/ml. Thus, extracts of M. elengi seed could be a source of antioxidant, cytotoxic and α-amylase inhibitory activity containing compounds.
Bangladesh Pharmaceutical Journal 25(1): 16-25, 2022 (January)
In vitro Antioxidant and Free Radical Scavenging Activity of the Bark of Dillenia indica L.
Authors: Akter Mst Jasmin , Khatun Rafeza , Khatune Naznin Ara , Alam AHM Khurshid , Rahman Md Aziz Abdur
Published: January 2022

The aim of the study was to explore the antioxidant and free radical scavenging activity of bark of Dillenia indica L. The methanolic extract (CME) of coarse powder of the dried bark was fractionated with pet-ether (PETF), chloroform (CHF), and water (AQF) and each fraction was investigated for antioxidant and free radical potentials. The phenolic contents of CME, CHF, PETF and AQF were found to be 90.2, 171.1, 52.1 and 158.1 and flavonoid contents 182.6, 340.2, 285.9, and 362.6 mg of GAE/g of dried extract, respectively. The total antioxidant activity of CME, PETF, CHF, AQF and standard catechin in terms of absorbance were 0.373, 0.707, 0.88, 1.051 and 0.804, respectively at 160 μg/ml concentration indicating AQF possessing the highest total antioxidant activity. In DPPH radical scavenging activity, the AQF and CHF showed potential radical scavenging activity followed by CME and PETF with IC50 values of 1.5, 2.5, 23 and 61 μg/ml, respectively, whereas standard ascorbic acid showed IC50 at 8 μg/ml. Among the extractives, AQF and CHF exhibited potent hydroxyl radical scavenging activity with IC50 values of 49.0 and 42 μg/ml followed by CME and PETF with IC50 of 86 and 168 μg/ml, respectively. In ferric-reducing antioxidant assay, AQF, CHF and CME (absorbance 2.262, 2.418 and 2.157, respectively) showed higher activity than that of standard (1.793) followed by PETF (absorbance 0.593). Since polyphenols like flavonoids play a vital role in controlling antioxidants, polyphenol rich extracts are potent source of antioxidants. Our data showed that the chloroform fraction of the bark of D. indica provided highest polyphenols and antioxidant activities, hence, can be used further as a source of natural antioxidants.
Bangladesh Pharmaceutical Journal 25(1): 38-43, 2022 (January)
Antibacterial Naphthaquinones from Necterium sp. Inhabited in Tinospora cordifolia
Authors: Murshid Gazi Monjur , Sohrab Md Hossain , Masud Mohammad Mehedi , Mazid Md Abdul
Published: January 2022

Numerous biologically active metabolites have previously been obtained from endophytes including endophytic fungi. This potentiality and prospect prompted us to find out new compounds having activity against pathogenic bacteria, from fungal endophyte, Necterium sp. isolated from the leaf of Tinospora cordifolia. We cultivated and developed the fungal strains on PDA medium and extracted on ethyl acetate after 28 days. Column chromatographic technique followed by preparative TLC was utilized to isolate secondary metabolites as pure crystalline solid. Two naphthoquinones namely anhydrofusarubin (1) and fusarubin methyl ether (2) were isolated from Necterium sp. The 1H and 13C NMR spectral data of the isolated compounds were analyzed and compared with previously published values to confirm the structure of the compounds. The compounds were assessed for antibacterial activity by resazurin based microdilution assay. Both of them showed sensitivity towards gram negative Pseudomonas aeruginosa but none was active against Staphylococcus aureus, a gram positive bacteria. The MIC values against P. aeruginosa for anydrofusarubin (1) and fusarubin methyl ether (2) were found to be 32- and 64-μg/ml respectively while the standard gentamycin showed MICs of 6.25 μg/ml (for S. aureus) and 12.5 μg/ml (for P. aeruginosa). The outcomes of our study suggest that anhydrofusarubin (1) and fusarubin methyl ether (2) are beneficial lead compounds to broaden the sphere of marketed antibacterial drugs.
Bangladesh Pharmaceutical Journal 25(1): 80-88, 2022 (January)
Potential of Prospective Medicinal Plants of Bangladesh for the Complementary Management of COVID-19
Authors: Shahriar Saimon , Sarker Md Moklesur Rahman , Soma Mahfuza Afroz , Jannat Tabassum , Mina Sadia Tasnim , Rahman Rabita , Rahman Mohammad Sharifur , Rashid Mohammad A
Published: January 2022

The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has been a healthcare disaster because of the unique and distinct characteristics of the pathogen, the easy and rapid transmission of the virus from humans to humans, the challenges in diagnosis and confirmation of the disease and the inability to invent and distribute safe and effective drugs or vaccines worldwide that would work against all the variants of coronavirus. Bangladesh, despite being a third-world country with limited health resources, has not been one of the worst-hit countries in the world but has still suffered with the loss of nearly eleven thousand people. Traditional and herbal remedies have become popular in this sub-continent since long ago and used for the treatment and management of different diseases including infectious disease. In this review, we have summarized the reports of immunostimulating, anti-inflammatory, antiviral, and respiratory distress syndrome improving activities of prospective indigenous plants of Bangladesh that may be recommended for use as complementary and alternative medicine or may be potential sources for the discovery and development of anti-COVID-19 medicaments. Thus, the review will be beneficial for the researchers, complementary and alternative medicines or herbal medicine manufacturers, formulators to find out and manage the potential herbal/nutraceutical/medicinal agents for the preparation of complementary and alternative medicines, as well as to the scientist for further research for the discovery and development of therapeutics/new drugs for the prevention and treatment of COVID-19 as well as other viral infections.
Bangladesh Pharmaceutical Journal 25(1): 89-114, 2022 (January)
New Drug Approvals Vol. 25(1)
Authors: Hossain Md Akbar
Published: January 2022

Abstract not available
Bangladesh Pharmaceutical Journal 25(1): 115-117, 2022 (January)
Modification of Frozen Elephant Trunk Technique for Acute Type-A Aortic Dissection - A Case Report
Authors: Gupta Saikat Das , Chanda PK , Adhikary DK
Published: January 2022

Acute type-A aortic dissection (ATAAD) is a dreadfully fatal cardiovascular emergency. The mortality rate among medically treated patients is 50% within two days. Surgery is the gold standard and urgent surgical treatment is indicated for all patients, except for those who are moribund or severely comorbid. However, early mortality after operation remains high (9–25%). We hereby present a case of 22 years young, male, Marfan patient with a family history of ATAAD treated successfully by us at Square Hospital Ltd by modified Bentall’s procedure with total arch replacement with Frozen Elephant Trunk (FET) technique.

University Heart Journal 2022; 18(1): 65-70
Violencia psicológica contra la mujer en la narrativa regional andina
Authors: Rodríguez-Berrocal Pío
Published: January 2022

El propósito es mostrar los elementos humorísticos y machistas, como formas de la violencia psicológica contra la mujer, en el discurso literario del libro Taita Serapio (2004)1. En los relatos destacan el humor, con que se aderezan las historias, y el machismo, como vías poderosas para atentar contra la integridad psicológica de la mujer. El personaje macho encarnado en Taita Serapio, individuo socarrón y pervertido, ve en cada mujer un instrumento de satisfacción sexual y burla. En esencia, Taita Serapio es caracterizado como un personaje con ciertas desviaciones sexuales llegando a un vago exhibicionismo. En este trabajo, se aplica la crítica y el análisis literario para mostrar de qué manera Zuzunaga construye el humor, de la mano con el machismo, a partir de lo grotesco o intrascendente en las circunstancias, en las controversias de los protagonistas. Fundamentalmente, el estudio se orienta, principalmente, por el conducto de la teoría de la crítica literaria psicoanalítica; además, de la teoría antropológica, para analizar los tópicos planteados.
Fases aguda y subaguda de chikunguña en San Joaquín y San Juan Nepomuceno, Bolívar, 2014-2015
Authors: Campo C. Alfonso , Vega Teodolinda , Martínez Durán Máncel Enrique
Published: January 2022

Introducción: chikunguña es una enfermedad de reciente introducción en América; en Colombia se inició su transmisión en 2014 en los municipios de Mahates (en el corregimiento de San Joaquín) y San Juan Nepomuceno en el departamento de Bolívar, Costa Atlántica; en San Joaquín y San Juan Nepomuceno el INS hizo seguimiento de los casos identificados en 2014.
Objetivos epecíficos: identificar las características demográficas y sociales de los casos de chikunguña en San Joaquín y San Juan Nepomuceno, estimar la frecuencia de chikunguña en sus fases aguda y subaguda en los dos lugares, identificar las características clínicas y epidemiológicas en fase aguda, establecer las características clínicas y epidemiológicas en la fase subaguda e identificar el subregistro por no consulta.
Metodología: se realizó un estudio descriptivo retrospectivo; la población en estudio es la población residente en el área urbana del corregimiento de San Joaquín (municipio de Mahates) y de San Juan Nepomuceno en el departamento de Bolívar; los datos se obtuvieron en búsqueda activa comunitaria y en seguimiento a cada caso identificado en fases aguda y subaguda; los resultados principales se midieron como proporciones.
Resultados: en San Joaquín, la tasa de ataque de chikunguña en fase aguda fue de 76,7 %; el 35,7 % no consultaron al médico; los signos y síntomas más
comunes fueron artralgias, fiebre y eritema; el 91,0 % de los casos tuvieron incapacidad para realizar labores diarias comunes; el 40,2 % de los casos agudos se identificaron en el seguimiento como casos subagudos, con mayor frecuencia en mujeres de 65 y más años; el 55,0 % de los casos subagudos no consultaron al médico; en San Juan Nepomuceno, la tasa de ataque de chikunguña en fase aguda de la población examinada fue de 47,4 %; el 55,0 % no consultaron al médico; los signos y síntomas más comunes fueron artralgias, fiebre y eritema; el 95,1 % de los casos tuvieron incapacidad para realizar labores diarias comunes; el 15,1 % de los casos agudos se identificaron en el seguimiento como casos subagudos, con mayor frecuencia en mujeres de 15 a 44 años; el 78,2 % de los casos subagudos no consultaron al médico.
Conclusiones: es probable que el manejo inadecuado con corticoides, la polifarmacia y no guardar el reposo necesario favorecieron la presencia de casos de la enfermedad en la fase subaguda, la incapacidad generada por la enfermedad causó dificultades a la población porque les impedía desempeñar sus labores que generalmente son manuales y de movilización.
Descripción de brote de parotiditis en establecimiento carcelario - Meta, Colombia, julio - septiembre 2017
Authors: Plata Casas Laura , Suárez Rangel Gloria Inés , Motaño Contreras Carolina , Gómez Claudia , González Marina Stella , Pelaez Dioselina
Published: January 2022

El 24 de julio 2017 la Institución penitenciaria y carcelaria del Meta (INPECM) notificó parotiditis entre prisioneros. Se generó una respuesta de investigación y control del brote en coordinación con la Secretaria de Salud municipal de Acacias, Secretaría de Salud del Meta e Instituto Nacional de Salud, con los objetivos de confirmar el brote, identificar la etiología, caracterizar los casos, para orientar acciones de control y prevención. Se realizó estudio descriptivo de serie de casos, con revisión de historias clínicas y resultados de laboratorios de muestras de hisopado bucal, sangre y orina tomadas en los casos, las cuales fueron procesados por RTPCR, ELISA indirecta, cultivo viral, genotipificación. El análisis en EPI-INFO 7.2.1.0, calculó tasas de ataque, proporciones y medias. La tasa de ataque fue de 2,2%. No fueron notificados casos de parotiditis cinco años previos en IMPECM. La edad promedio (rango) de casos fue de 28 años (rango 20-40); los principales síntomas fueron edema, dolor en región parotídea/submaxilar o cuello (96%), fiebre (86%); los resultados de laboratorio fueron positivos a virus de parotiditis. Hubo Confirmación de brote por virus de parotiditis en el INPECM. Algunas historias clínicas estaban incompletas o ilegibles. Se recomendó vacunación a prisioneros del IMPECM y fortalecer medidas de control.
TO A QUESTION OF THE DIFFERENTIATED APPLICATION OF OSTEOPLASTIC MATERIAL S AT FILLING OF A DENTAL SOCKET
Authors: Boyko E. M. , Stomatov D. V. , Gabrielian N. G. , Chagarov Art. A. , Ivashkevih S. G.
Published: January 2022

This article discusses osteoplastic materials of various origin for differentiated use, as well as the results of their usage at filling of the dental socket under histological control.
RESTORATION OF ALVEOLAR DEFECTS USING ALLOGENIC BONE BLOCKS
Authors: Boyko E. M. , Dolgalev A. A. , Eldashev D. S.-A. , Musaev M. G. , Ivashkevih S. G.
Published: January 2022

Dental manipulation is often associated with the placement of implants in patients with partial or complete tooth loss. Before implants are placed, the dental surgeon is most often faced with a bone deficit in the alveolar ridge area. With any technique, the main disadvantage of autologous bone extraction is the additional trauma to the patient. Reducing the invasiveness of the surgical steps is particularly relevant in elderly patients with comorbidities [1, 2, 3]. In this article, the authors propose to use bone blocks of allogenic origin when restoring defects of the alveolar ridge of the jaw bones.
ANALYSIS OF THE EFFECTIVENESS OF IMPLANT TREATMENT IN PATIENTS WITH TOOTH LOSS
Authors: Dzhafarov E. M. , Sergeev Y. S. , Samoylov A. A. , Shulga G. S.
Published: January 2022

This article presents an analysis of the survival rate of implants widely represented on the Russian market. The authors summarized the statistical material for the last 8 years.
RUSYA’NIN YAKIN ÇEVRESİNİ KORUMA POLİTİKASI VE SOĞUK SAVAŞ İZLENİMLERİ (2008 RUSYA-GÜRCİSTAN SAVAŞI VE 2014 UKRAYNA KRİZİ)
Authors: ALPTEKİN Gökhan
Published: January 2022

Kafkasya ve Karadeniz doğudan batıya uzanan enerji hatları açısından önemli bölgelerdir. Gürcistan ve Ukrayna ise bu bölgelerin hem NATO’nun hem de AB’nin güvenlik güvenlik politikalarında kritik bir konuma sahip ülkelerindendir. Söz konusu ülkeler gerek Batının enerji güvenliğini sağlamak gerekse Asya’nın batıya açılımını kontrol etmek için kilit noktalardan biridir. Bu noktalar aynı zamanda Rusya’nın yakın çevresinde yer almaktadır. 2008 Rusya–Gürcistan Savaşı ve 2014 Ukrayna Krizi, Rusya’nın Kafkasya, Karadeniz ve Doğu Avrupa gibi bölgelerde Sovyetler’in dağılmasından sonra meydana gelen güç boşluğunun kendisi dışında bir aktör tarafından doldurulmasına müsaade etmeyeceğini göstermiştir. Her ne kadar ABD ve AB günümüze kadar yumuşak güç kullanarak bölgede varlık göstemeye çalışmışsa da Rusya bunun karşılığında sert güç kullanmaktan çekinmemiştir. Bu izlenim dünyada Rusya ile ABD arasında yeni bir soğuk savaşın başladığını düşündürmüştür. Bu araştırma, somut veriler ışığında Rusya ile ABD arasında yaşananların mevcut uluslararası statükoyu bozma ve yeni bir soğuk savaşa yol açma potansiyelini incelemeyi hedeflemektedir. Bu kapsamda Rusya’nın süper güç statüsüne yükselme ihtimali ve AB’nin muhtemel tepkileri de araştırılan konular arasındadır.
Campus Fossil Fuel Divestment (CFFD) Counter-Repertoires
Authors: Ilnyckyj Milan
Published: January 2022

Under the contentious politics theoretical framework the actions of activists are understood metaphorically as a particular set of 'performances' drawn from a broader potential 'repertoire.' The expectation within the framework is that as activist repertoires are deployed defenders of the status quo will undertake performances of their own to avoid taking the actions demanded. My thesis overall examines how organizing CFFD campaigns affected the political beliefs and behaviours of activists. This excerpt catalogues the main counter-repertoires resisting fossil fuel divestment on the part of universities, the fossil fuel industry, and governments. It is relevant both for activists seeking to critically assess the movement and for scholars designing protective ethics protocols for use with activist research participants.
Attraction vs. Alignment as Drivers of Collective Motion
Authors: Strömbom Daniel , Tulevech Grace
Published: January 2022

Moving animal groups exhibit a range of fascinating behaviors. The standard explanation for how these groups form and function is that the individual animals interact via attraction, repulsion, and alignment, where alignment is proposed to drive the collective motion. However, it has been shown both experimentally and theoretically that alignment interactions are not required to induce group level alignment. In particular, via the use of self-propelled particle models it has been established that several other mechanisms induce group level alignment (aka polarization) in combination with attraction alone. However, no systematic comparison of these mechanisms among themselves, or with explicit alignment, has been presented and it remains unclear how, or even if, they can be distinguished at the collective level. Here, we introduce two previously unreported mechanisms, burst-and-glide and burst-and-stop, and show via simulation that they also induce polarization in combination with attraction alone. Then, we compare the polarization inducing characteristics of six mechanisms; asymmetric interactions, asynchrony, anticipation, burst-and-glide, burst-and stop, and explicit alignment. We show that the mechanisms induce polarization in different parts of the attraction parameter space, that the route to polarization from uniformly random initial conditions, as well as repolarization following strong perturbations, is markedly different among the mechanisms. In particular, we find that alignment based and non-alignment based mechanisms can be distinguished via their polarization and repolarization processes. These findings further challenge the current alignment based theory of collective motion and may contribute to a more versatile theory of collective motion across scales.
Hip–Knee Coupling Exoskeleton With Offset Theory for Walking Assistance
Authors: Ma Jianfeng , Sun Decheng , Chen Xiao
Published: January 2022

To alleviate the influence of aging on the elderly, a hip–knee coupling exoskeleton with offset theory is designed in this article to improve people’s athletic ability. With the novel design, the unique application strategy of the offset principle for hip and knee joints is developed, and a hip–knee coupling mechanism is proposed to solve the discrete power assistance problem for the knee joint. To acquire the success of the design, the mathematical model of the coupling mechanism is established to optimize the load environment of the exoskeleton system, and furthermore, an algorithm adapted to human movement is proposed to determine the monotonicity of the cam profiles. For the selection of the elastic parameters in the coupling mechanism, the sensitivity condition is proposed, and the human–machine interaction model of the KESM is further established. A man–machine coupling model was used to verify the scientificity of the exoskeleton design, and the comparison between the joint powers with or without exoskeleton indicated that the exoskeleton theoretically saved at least 20% of the human body’s energy.
Photocatalytic Material–Microbe Hybrids: Applications in Environmental Remediations
Authors: Yu Yadong , Wang Shanshan , Teng Jinrui , Zupanic Anze , Guo Shuxian , Tang Xiaobin , Liang Heng
Published: January 2022

Environmental pollution has become one of the most urgent global issues that we have to face now. Searching new technologies to solve environmental issues is of great significance. By intimately coupling photocatalytic materials with microbes, the emerging photocatalytic material–microbe hybrid (PMH) system takes advantages of the high-efficiency, broad-spectrum light capture capability of the photocatalytic material and the selectivity of microbial enzymatic catalysis to efficiently convert solar energy into chemical energy. The PMH system is originally applied for the solar-to-chemical production. Interestingly, recent studies demonstrate that this system also has great potential in treating environmental contaminations. The photogenerated electrons produced by the PMH system can reductively decompose organic pollutants with oxidative nature (e.g., refractory azo dyes) under anaerobic circumstances. Moreover, based on the redox reactions occurring on the surface of photocatalysts and the enzymatic reactions in microbes, the PMH system can convert the valences of multiple heavy metal ions into less toxic or even nontoxic status simultaneously. In this review, we introduce the recent advances of using the PMH system in treating environmental pollutions and compare this system with another similar system, the traditional intimately coupled photocatalysis and biodegradation (ICPB) system. Finally, the current challenges and future directions in this field are discussed as well.
Update of Argentina’s Regulatory Policies on the Environmental Risk Assessment
Authors: Vesprini Facundo , Whelan Agustina Ines , Goberna María Florencia , Murrone Mariana Lucía , Barros Gabriela Evangelina , Frankow Andrés , Godoy Perla , Lewi Dalia Marcela
Published: January 2022

The Environmental Risk Assessment (ERA) of genetically modified (GM) crops in Argentina is carried out by the National Advisory Commission on Agricultural Biotechnology (CONABIA) and the Innovation and Biotechnology Coordination (CIyB). Both have a large experience with this assessment, since 1991, when CONABIA was created. The continuous support to biotechnology as a state policy and as part of the decision to encourage developers in the regulatory process has helped make progress in the revision of the regulations. The experience gained during the last 30 years and the worldwide scientific advances supported the bases to update the regulatory framework. Focusing on the biosafety strengthening and the improvement of the applicant’s experience in the GM crops evaluation process, during 2020 and 2021, the ERA went through a reviewing process. Some important modifications were made, such as (i) the assessment of stacked GM crops with focus on the possible interactions between transgenes and the expression products, (ii) the strengthening of the ERA taking into account the transportability of data and conclusions from the Confined Field Trials (CFTs), (iii) the adoption of Familiarity and History of Safe Use (HOSU) concepts on the risk assessment of the expression products, (iv) the special considerations for the unintended effects of insertional sites, and (v) as a post commercial release of GM crops, the Insect Resistance Management Plan (IRMP) was reformulated. These novel approaches enhance the ERA; they make it more efficient by applying the science criteria and the accumulated experience and scientific bibliography on the topic.
Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Accelerate Diabetic Wound Healing via Ameliorating Oxidative Stress and Promoting Angiogenesis
Authors: Yan Chenchen , Xv Yan , Lin Ze , Endo Yori , Xue Hang , Hu Yiqiang , Hu Liangcong , Chen Lang , Cao Faqi , Zhou Wu , Zhang Peng , Liu Guohui
Published: January 2022

Diabetic wounds remain a great challenge for clinicians due to the multiple bacterial infections and oxidative damage. Exosomes, as an appealing nanodrug delivery system, have been widely applied in the treatment of diabetic wounds. Endovascular cells are important component cells of the vascular wall. Herein, we investigated the effects of HUCMSCs and HUC-Exos (exosomes secreted by HUCMSCs) on diabetic wound healing. In this study, HUVECs were coincubated with HUCMSCs, and HUC-Exos were utilized for in vitro and in vivo experiments to verify their roles in the regulation of diabetic wound healing. Our results demonstrated that HUCMSCs have the ability to regulate oxidative stress injuries of endothelial cells through exosomes and accelerate diabetic cutaneous wound healing in vitro. The present study suggests that HUC-Exos accelerate diabetic cutaneous wound healing, providing a promising therapeutic strategy for chronic diabetic wound repair.
Revealing Critical Characteristics of Mobility Patterns in New York City During the Onset of COVID-19 Pandemic
Authors: Rajput Akhil Anil , Li Qingchun , Gao Xinyu , Mostafavi Ali
Published: January 2022

New York has become one of the worst-affected COVID-19 hotspots and a pandemic epicenter due to the ongoing crisis. This paper identifies the impact of the pandemic and the effectiveness of government policies on human mobility by analyzing multiple datasets available at both macro and micro levels for New York City. Using data sources related to population density, aggregated population mobility, public rail transit use, vehicle use, hotspot and non-hotspot movement patterns, and human activity agglomeration, we analyzed the inter-borough and intra-borough movement for New York City by aggregating the data at the borough level. We also assessed the internodal population movement amongst hotspot and non-hotspot points of interest for the month of March and April 2020. Results indicate a drop of about 80% in people’s mobility in the city, beginning in mid-March. The movement to and from Manhattan showed the most disruption for both public transit and road traffic. The city saw its first case on March 1, 2020, but disruptions in mobility can be seen only after the second week of March when the shelter in place orders was put in effect. Owing to people working from home and adhering to stay-at-home orders, Manhattan saw the largest disruption to both inter- and intra-borough movement. But the risk of spread of infection in Manhattan turned out to be high because of higher hotspot-linked movements. The stay-at-home restrictions also led to an increased population density in Brooklyn and Queens as people were not commuting to Manhattan. Insights obtained from this study would help policymakers better understand human behavior and their response to the news and governmental policies.
The Tipped Balance of ILC1/ILC2 in Peripheral Blood of Oral Lichen Planus Is Related to Inflammatory Cytokines
Authors: Wang Zi-Ming , Zhang Jing , Wang Fang , Zhou Gang
Published: January 2022

Oral lichen planus (OLP) is an immune-inflammatory disease mediated by T cells. Innate lymphoid cells (ILCs) constitute a novel family of immune cells that initially originate from common innate lymphoid progenitors. Termed “T cells counterparts,” ILCs play a prominent role in inflammatory-immune diseases. However, the characterization of ILCs and their related induced factors were unclear in OLP. In the present study, the phenotypic characteristics of ILCs and their correlation with inflammatory cytokines were explored in the peripheral blood of OLP patients and healthy controls. We found that the proportion of total ILCs was expanded in OLP and was positively correlated with disease severity. The highly skewed distribution of ILC subpopulations was notable in OLP. Specifically, the frequency of ILC1s was significantly increased, while that of ILC2s was significantly reduced in total ILCs of OLP, resulting in the markedly elevated ILC1/ILC2 ratio in OLP. Correspondingly, ILCs in OLP displayed high expression of T-bet but low expression of GATA3. In addition, the IFN-γ expression level was elevated in ILC1s, whereas the IL-4 expression level was decreased in ILC2s. Moreover, ILC-associated activators IL-12, IL-18, and IL-1β were upregulated in OLP plasma, with IL-12 and IL-1β both positively correlated with the ILC1/ILC2 ratio. Further in vitro stimulation tests indicated that OLP plasma remarkedly increased the ILC1/ILC2 ratio, especially that IL-12 and IL-1β tipped the balance between ILC1s and ILC2s toward ILC1s in total ILCs. Overall, elevated levels of IL-12 and IL-1β might act as environmental cues in tipping the balance of ILC1/ILC2 in the peripheral blood of OLP, contributing to the immune dysregulation in OLP.
Pathogenic Variations of Homologous Recombination Gene HSF2BP Identified in Sporadic Patients With Premature Ovarian Insufficiency
Authors: Li Shan , Xu Weiwei , Xu Bingying , Gao Shuchang , Zhang Qian , Qin Yingying , Guo Ting
Published: January 2022

Premature ovarian insufficiency (POI) is defined as depletion of ovarian function before 40 years of age, which affects 3.7% of women in reproductive age. The etiology of POI is heterogeneous. Recently, with the widespread use of whole-exome sequencing (WES), the DNA repair genes, especially for those involved in meiosis progress, were enriched in the causative gene spectrum of POI. In this study, through the largest in-house WES database of 1,030 patients with sporadic POI, we identified two novel homozygous variations in HSF2BP (c.382T>C, p.C128R; c.557T>C, p.L186P). An in vitro functional study revealed that both variations impaired the nuclear location of HSF2BP and affected its DNA repair capacity. Our studies highlighted the essential role of meiotic homologous recombination genes in the pathogenesis of sporadic POI.
Identification of Prognostic Biomarkers for Bladder Cancer Based on DNA Methylation Profile
Authors: Zhang Shumei , Zhang Jingyu , Zhang Qichao , Liang Yingjian , Du Youwen , Wang Guohua
Published: January 2022

Background: DNA methylation is an important epigenetic modification, which plays an important role in regulating gene expression at the transcriptional level. In tumor research, it has been found that the change of DNA methylation leads to the abnormality of gene structure and function, which can provide early warning for tumorigenesis. Our study aims to explore the relationship between the occurrence and development of tumor and the level of DNA methylation. Moreover, this study will provide a set of prognostic biomarkers, which can more accurately predict the survival and health of patients after treatment.

Methods: Datasets of bladder cancer patients and control samples were collected from TCGA database, differential analysis was employed to obtain genes with differential DNA methylation levels between tumor samples and normal samples. Then the protein-protein interaction network was constructed, and the potential tumor markers were further obtained by extracting Hub genes from subnet. Cox proportional hazard regression model and survival analysis were used to construct the prognostic model and screen out the prognostic markers of bladder cancer, so as to provide reference for tumor prognosis monitoring and improvement of treatment plan.

Results: In this study, we found that DNA methylation was indeed related with the occurrence of bladder cancer. Genes with differential DNA methylation could serve as potential biomarkers for bladder cancer. Through univariate and multivariate Cox proportional hazard regression analysis, we concluded that FASLG and PRKCZ can be used as prognostic biomarkers for bladder cancer. Patients can be classified into high or low risk group by using this two-gene prognostic model. By detecting the methylation status of these genes, we can evaluate the survival of patients.

Conclusion: The analysis in our study indicates that the methylation status of tumor-related genes can be used as prognostic biomarkers of bladder cancer.
Trap-TRAP, a Versatile Tool for Tissue-Specific Translatomics in Zebrafish
Authors: Corbacho Jorge , Sanabria-Reinoso Estefanía , Buono Lorena , Fernández-Miñan Ana , Martínez-Morales Juan R.
Published: January 2022

Developmental and physiological processes depend on the transcriptional and translational activity of heterogeneous cell populations. A main challenge in gene expression studies is dealing with this intrinsic complexity while keeping sequencing efficiency. Translating ribosome affinity purification (TRAP) methods have allowed cell-specific recovery of polyribosome-associated RNAs by genetic tagging of ribosomes in selected cell populations. Here we combined the TRAP approach with adapted enhancer trap methods (trap-TRAP) to systematically generate zebrafish transgenic lines suitable for tissue-specific translatome interrogation. Through the random integration of a GFP-tagged version of the large subunit ribosomal protein L10a (EGFP-Rpl10a), we have generated stable lines driving expression in a variety of tissues, including the retina, skeletal muscle, lateral line primordia, rhombomeres, or jaws. To increase the range of applications, a UAS:TRAP transgenic line compatible with available Gal4 lines was also generated and tested. The resulting collection of lines and applications constitutes a resource for the zebrafish community in developmental genetics, organ physiology and disease modelling.
Fluorescent Ligand-Based Discovery of Small-Molecule Sulfonamide Agonists for GPR120
Authors: Ma Siyue , Li Zhenzhen , Yang Yueli , Zhang Ling , Li Minyong , Du Lupei
Published: January 2022

As a critical member of G protein-coupled receptors (GPCRs), G protein-coupled receptor 120 (GPR120) is a potential target for many physiological diseases, such as type 2 diabetes mellitus, inflammation, and obesity. Considering that small-molecule fluorescent ligands can combine the advantages of visualization, high sensitivity and selectivity, we initially undertook an effort to develop a series of fluorescent ligands to track GPR120 and establish a method to screen GPR120 agonists. The representative fluorescent ligand N1 possesses suitable optical property, equitable biological activity, and high fluorescence imaging feasibility, therefore, based on compound N1, we subsequently founded a bioluminescence resonance energy transfer (BRET) competition binding assay to screen three series of sulfonamide GPR120 agonists we developed herein. The activity evaluation results revealed that compound D5 was a potent GPR120 agonist with high activity and selectivity. Moreover, compound D5 exhibited a significant glucose-lowering effect in db/db mice, which indicates its potential application in the treatment of type 2 diabetes mellitus in vivo. It is anticipated that our fluorescent ligand-based method is a useful toolbox and will find broad applications in the discovery of small-molecule agonists for GPR120.