bluuebunny/crossref_metadata_2025 huggingface dataset:
The new role of the technological component in the social reality of the digital transition era
Authors:   St Petersburg Mining University, Shestakova Irina G.
Published: September 2022

The article explicates a new factor that is relevant for researchers of social processes occurring at a current time. For the first time in the history of mankind, activity at any given moment must be correlated with unpredictable revolutionary development of the technological environment, the result of which, during one human life, repeatedly transforms the socioeconomic environment. In the past history of mankind, when studying social dynamics at any particular moment in time, the factor of the development of the technological environment could be neglected, despite the fact that the state of the technological environment always predetermined the state of the social environment. This action was possible because, within the limits of human life, the technological environment could be perceived as static (constant scenery for the action of the social). Modernity, characterized by a specific pace of development of the digital environment, brings fundamental transformations to this picture. The radical acceleration of the pace of technological development, combined with the focus of this development on the field of information technology, determines the unprecedented originality of the digital era that has come. It is shown that under conditions of the critical speed of transformation processes, the horizons of scientific foresight are sharply narrowed. The author defines the fundamental need for a concept of “techno”. Thus, contemporary social theories require an inextricable connection between the concepts of “socio-technological”.
The infosphere of theological schools of the Russian Empire in the 19th — early 20th century
Authors:   St. Petersburg State University, Chumakova Tatiana V.
Published: September 2022

The article explores a field quite new for Russian religious studies: research into the infosphere of religious institutions. In our case, the term “infosphere” defines a totality of institutions and informational resources of various origin, as well as channels of research communications, including verbal communication, those providing the development of this infosphere. At that, we rely on works by one of the creators of contemporary philosophy of information Luciano Floridi, who built that neologism according to the pattern of the term “biosphere” and put it in the research circulation in the mid 1990s, in the context of studying the new informational reality. In this work, we consider a small segment of the research of infosphere: studying the infosphere of the Orthodox theological schools of the Russian Empire of the nineteenth and early twentieth centuries. We analyze the main methodological approaches to studying the noosphere of seminaries and theological academies, the historiography, and the sources of that topic. The scale of the tasks requires the involvement of a wide range of sources. There are various written materials, both printed matters and manuscripts. There are catalogues of libraries collected in seminaries and theological academies, lists of personal libraries of teachers of theological educational institutions. Another valuable source of data on the infosphere of theological schools is a variety of notes and plans of lectures, journals of meetings of councils and conferences organized in theological academies, correspondence, and memoirs. Analysis of the content of periodicals makes it possible to reconstruct the informational field of teachers and students of theological educational institutions of the Russian Empire. It allows us to make a complex research of the circle of reading of representatives of the clergy, which played a significant role in the Russian culture of the pre-Soviet period.
Fecal sludge treatment in a pilot-scale vertical-flow constructed wetland for the removal of helminth eggs
Authors: Letah Nzouebet Wilfried Arsène , Soh Kengne Ebenezer , Rechenburg Andrea , Nana Ndangang Jean-Jules , Kengne Noumsi Ives Magloire
Published: September 2022

Eliminating parasites in fecal sludge (FS) remains one of the major concerns in developing countries. To address this issue, experiments were conducted in triplicate vertical-flow constructed wetland (VFCW) units corresponding to free flow, 7 days and 14 days of retention time (RT). The effect of plant density on the system's performance was monitored in each planted bed unit and compared to the non-planted unit (standard). Following a bi-monthly application rate of FS at a nominal load of 200 kg TS m−2 year−1, the performance of the system in terms of helminth egg removal was calculated for each hydraulic RT tested. Untreated FS applied on the bed units contained high parasitic egg loads with a median number of 62.51 helminth eggs/g. The removal efficiencies of helminth eggs ranged from 82 to 100% in the leachates and were affected by the hydraulic RTs and the presence of plants (p < 0.05). On the other hand, accumulated biosolids on the bed units still contained high concentrations of pathogens exceeding the WHO standards and should not be applied directly in agriculture.
Comparative photo-degradative treatment of dyeing industry wastewater containing diazo dye by UV/Peroxydate and UV/Persulfate − oxidation processes
Authors: Laftani Yasmine , Chatib Baylassane , Boussaoud Abdelghani , Hachkar Mohsine , El Makhfouk Mohammed
Published: September 2022

Generation of anion sulfate radicals (SO4•−) and hydroxyl radicals (HO•) by UV/Persulfate and the UV/Peroxydate processes have been successfully studied to degrade Ponceau S dye. Under [PS] = 0.06 mM; [H2O2] = 2 mM; [S2O82-] = 2 mM, the UV/Persulfate process was effective (kapp = 0.163 min−1) than the UV/Peroxydate process (kapp = 0.054 min−1). The lack of dissolved oxygen, the excess of hydrogen peroxide (H2O2) dosage at 2 mM, and the alkaline pH of 10.01 significantly reduced the UV/Peroxydate efficiency. The scavenging effect of the hydrogenocarbonates and nitrates on the PS dye degradation by the UV/Persulfate process was significant, whereas chlorides had a slight influence. The composition of seawater in chlorides, sulfates, carbonates, and bromides decreased the photoactivity of the studied processes. The presence of phenol showed that the reactive affinity of the (HO•) is more superior to the SO4•−. The UV/Persulfate process achieved 82.35% of chemical oxygen demand removal against 59.56% for the UV/Peroxydate in about 100 min. This study demonstrated that the UV/Persulfate process is a viable option for PS dye degradation. To the best of our knowledge, this is the first report for studying the PS dye degradation under varying some new operational factors. However, the identification of by-products, their nature, and their concentration requires special attention.
Study on cooperative constraint zoning of water environment
Authors: Liu Lanxin , Li Zhidong , Zhao Penglei , Leng Xuefei
Published: September 2022

This study comprehensively considers two elements of water environmental sensitivity and pressure using the combination of qualitative analysis and quantitative calculation. And it puts forward the water environmental collaborative constraint zoning method and focuses on the construction of the water environmental collaborative constraint zoning evaluation index system using the fuzzy optimization programming model to determine the index weight. This study takes the Liaohe River Basin in Liaoning Province as a study area through two-dimensional quadrant analysis of water environmental sensitivity and pressure; it is divided into four types of areas: high-pressure and high-sensitivity area (HP-HS area), high-pressure and low-sensitivity area (HP-LS area), low-pressure and high-sensitivity area (LP-HS area) and low-pressure and low-sensitivity area (LP-LS area), respectively. The results show that the proportion of HP-HS area is 28.4%, the proportion of HP-LS area is 10.1%, the proportion of LP-HS area is 22.2% and the proportion of LP-LS area is 39.3%, respectively. The evaluation results are in line with the actual situation of the Liaohe River Basin in Liaoning Province. According to the results of different zoning, this research puts forward the optimization and adjustment scheme of industrial layout to achieve the comprehensive and coordinated sustainable development of population, economy, society, and environment in the study area. The research results also have been applied to the formulation of ‘14th Five-Year Plan’ for water ecological environment protection of key river basins in Liaoning Province.
Cardiovascular Dysautonomia in Patients with Breast Cancer
Authors: Geraldes Vera , Caldeira Elisa , Afonso Ana , Machado Filipa , Amaro-Leal Ângela , Laranjo Sergio , Rocha Isabel
Published: September 2022

Breast cancer is the most frequent malignant disease among women, being responsible for a considerable percentage of fatalities and comorbidities every year. Despite advances in early detection and therapy, evidence shows that breast cancer survivors are at increased risk of developing other chronic conditions, such as cardiovascular diseases.

Autonomic dysfunction is an emerging, but poorly understood topic that has been suggested as a risk factor for cardiovascular disease in breast cancer patients. It clinically manifests through persistently elevated heart rates and abnormal heart rate variability, even before any signs of cardiovascular dysfunction appear. Since changes in the left ventricular ejection fraction only manifest when myocardial injury has already occurred, it has been hypothesized that autonomic dysfunction can constitute an early biomarker of cardiovascular impairment in breast cancer patients.

This review focuses on the direct and indirect effects of cancer and its treatment on the autonomic nervous system in breast cancer patients. We highlight the mechanisms potentially involved in cancer and antineoplastic therapy-related autonomic imbalance and review the potential strategies to prevent and/or attenuate autonomic dysfunction.

There are gaps in the current knowledge; more research in this area is needed to identify the relevance of autonomic dysfunction and define beneficial interventions to prevent cardiovascular disease in breast cancer patients.
effect of vocabulary mind mapping through Youdao Dict. on vocabulary learning of undergraduates with high and low motivation
Authors: Cao Dan , Ismail Lilliati
Published: September 2022

Students with limited English vocabulary and motivation it’s a challenge for their English instructor to boost their learning autonomy and drive. Therefore, instructors must discover an efficient vocabulary learning technique to employ in and after class to boost vocabulary proficiency and learning motivation. This study will explore the influence of the Youdao Dict. on English Vocabulary Acquisition of Students with Various Motivations This research uses a quasi-experimental methodology and one freshman class. 30 students are enrolled. Data will be collected using the Intrinsic/Extrinsic Motivation Scale of English Learning (I/EMSEL) and the Core English Vocabulary Test (CEV). They'll be sorted into high-and low-motivation groups. The middle level will be cut. Two groups' pre- and post-test learning will be assessed. The data will also be supported by classroom observation and interviews. In this research, the Paired Sample T-test is utilised to examine data. The findings suggest that the proposed cognitive process-based learning model (VMMYD) may boost students' learning strategies and vocabulary acquisition, and instructors can coach students in and after class to improve learning motivation.
Hakkâri ili 4-12 yaş arası okul çağı erkek çocuklarında genital anomali oranları
Authors: Erten Elif
Published: September 2022

Amaç: Bu çalışmada ilimizdeki anaokulu, ilkokul ve ortaokula devam eden erkek çocuklarında dış genital organ anomali oranlarını bulmayı amaçladık.
Gereç ve yöntem: Tarama için gerekli izinler alındıktan sonra 27 adet okulda öğrenim görmekte olan 3685 erkek çocuk çalışmaya dahil edildi. Tüm öğrenciler aynı çocuk cerrahisi uzmanı tarafından okullarında muayene edildi ve dış genital organ anomalileri kaydedildi.
Bulgular: Öğrencilerin yaşları 4 ila 13 arasında idi. Çalışmaya katılan 3685 öğrencinin 137’inde (%3,7) anomali saptandı. Saptanan anomaliler; inmemiş testis (%0,8), inguinal herni (%1,0), hipospadias (%0,7), hidrosel (%0,9) ve sünnet komplikasyonu (%0,2) idi.
Sonuç: Çalışmamızda dış genital anomalilerin oranı oldukça yüksek olarak tespit edildi. Sonuçlar okul çağında yapılan tarama muayenelerinin ve aile ilgisinin yetersiz olduğunu düşündürmektedir. Okul öncesi ve okul çağındaki çocuklarda genital anomalilerin erken tanı ve tedavisini sağlamak amaçlı okul taramalarının düzenli hale getirilmesi gerekmektedir.
İki Yaş Altında Supraventriküler Taşikardi Tanısı Alan Çocuk Hastaların Klinik İzlem Sonuçlarının Değerlendirilmesi
Authors: Aval Enver , Laloğlu Fuat , Ceviz Naci
Published: September 2022

Amaç: İki yaş altında supraventriküler taşikardi tanısı alan yenidoğan ve süt çocuklarının klinik izlem sonuçlarının değerlendirilmesi amaçlandı.
Gereç ve Yöntem: Çalışmaya toplam 50 hasta dahil edildi. Alınan olguların tıbbi kayıtları retrospektif olarak incelendi ve demografik ve klinik özellikleri ve izlem sonuçları çıkarıldı.
Bulgular: Hastaların yaş ortalaması 3.28±6.02 ay olup %60 vaka yenidoğandı. Hastaların %32’sinde konjenital kalp hastalığı saptandı. Bir hastada taşikardi cerrahi ilişkili idi. Hastalarımızın 30’u kliniğimize taşikardi esnasında başvurmuştu. Hastalarımızın %30’unda başvuru esnasında kalp yetersizliği bulguları mevcut idi. Üç hastada fetal supraventriküler taşikardi tespit edilmiş, ikisinde hidrops gelişmişti. En sık elektrofizyolojik mekanizma atriyoventriküler reentry taşikardi (%70) olarak düşünüldü. Toplam 43 hastaya akut tedavi verildi. Bunların ikisinde taşikardi durdurulamadı. Toplam 49 hastaya kronik tedavi başlandı. Tekli veya kombine kronik antiaritmik tedavi başlanmış olup kronik izlem yapılabilmiş olan 34 hastanın izlem süresi ortalama 43.4±44.4 ay’dı. Hastaların %85,3’ünün ilaçları takipte kesildi; spontan rezolüsyon=%93.1, ablasyon sonrası=%6,9. Spontan rezolüsyon düşünülerek ilaçları kesilen üç hastada aritmi nüks etti. Wolff-Parkinson-White paterni saptanan ve izlemi yapılabilen kalan 6 hastadan üçüne ablasyon yapılması sağlandı.
Sonuç: Verilerimiz, 2 yaş altındaki çocuklarda görülen supraventriküler taşikardilerin büyük çoğunluğunun atriyoventriküler reentrant taşikardi nedeniyle oluştuğuna, kalp yetersizliği bulguları olan süt çocuklarında supraventriküler taşikardi yönünden değerlendirmenin önemli olduğuna, vakaların büyük çoğunluğunun kronik profilaksiye ihtiyaç duyduğuna işaret etmektedir. Vakaların çoğunluğunda tek ilaçla profilaksi mümkün olmakta, az sayıda hastada kombinasyon tedavisi gerekmektedir. Önemli sayıda süt çocuğunda spontan rezolüsyon görülmüştür. Kesin tedavide uygun hastalar için kateter ablasyon önemli bir seçenektir.
Diagnostic Algorithm in the Pediatric Appendicitis; A Prospective Clinical Study
Authors: Bostancı Süleyman Arif , Güneş Altan , Güney Doğuş , Demirtaş Gökhan , Öztorun Can , Ertürk Ahmet , Demir Sabri , Erten Elif , Azılı Müjdem Nur , Şenel Emrah
Published: September 2022

Aim: We compare the diagnostic approaches: surgeon prediction, surgeon prediction plus ultrasound imagining (US) as the first-line imaging modality, and magnetic resonance imagining (MRI) as the second-line imaging for suspected pediatric appendicitis.
Methods: Three hundred sixty-one patients with a clinically suspected appendicitis were prospectively divided into three groups by the type of diagnostic approach.
Results: A total of 51 patients were diagnosed via only the surgeon prediction. Of the patients, 254 only underwent a US examination, and 56 patients underwent both US and MRI. Considering the diagnostic groups, the accuracy of both the “surgeon prediction only” and “surgeon prediction + US + MRI” groups was 100%. The “surgeon prediction + US” group revealed a sensitivity value of 62,4% with an accuracy rate of 59,8%. The sensitivity and specificity of US were 61,0%, 65,5%, respectively. These values were 100% for MRI. The sensitivity, specificity of our institutional algorithm were 100,0%, 94,4%, and the positive-negative predictive values were 94,7%, 100%.
Conclusions: To diagnose appendicitis in children, surgeon’s assessment, prudence, and clinical evaluation should be the first method of diagnosis. US is a useful method to support surgeons in ensuring an accurate diagnosis, and MRI can be trusted as an additional method to verify a correct diagnosis.
Neonatal Hearing Screening Results with Screening ABR Protocol
Authors: Sarı Neslihan , Bülbül Ayşe , Filoğlu Ersü Nilay
Published: September 2022

Aim:The study aimed to present the results of our universal newborn hearing screening results at a secondary care hospital in Mardin by ABR and review with the literature.
Materials and method: A total of 7134 newborns were screened between January 2021 and December 2021using ABR as first, second, third steps. Newborns who failed and at risk are referred to reference hospital and the results were obtained from the records.
Result:Of the 7134 newborns,6179 are first test, 955 were retested. Failure in first test was 13.3%. 235(3.2%) of patients were referred to reference center. 0.5% were referred due to test failure, 2.7% were referred due to risk. 27 patients(3.7%) were obtained from records of reference center as abnormal results in clinical Automated Brain stem Response(ABR).16 of them (0.5%) were congenital hearing loss(CHL) who need rehabilitation.
Conclusion: Incidence of hearing loss and the rate of failure in first and second test were consistent with the literature. However, reference rate increased due to reference caused by risk factors.
Trisomy 14 Mosaicism Including Concomitant Uniparental Disomy: Population Frequency, Cytogenetic Profile, Sex Ratio, Maternal Age, and Obstetric History.
Authors:   Academy of Molecular Medicine, St. Petersburg, Russian Federation, Kovaleva Natalia V. , Cotter Philip D. ,   ResearchDx Inc., Irvine, CA, USA
Published: September 2022

Mosaicism for trisomy of chromosome 14 (T14) is a very rare chromosomal disease in liveborn patients. Since the 1970s, when the first patients with mosaicism for T14 were reported, a number of studies on the clinical manifestations of this abnormality have been published. No information on epidemiological parameters was known except for the rarity of the disease and its predominance among female carriers. This was the first systematic review of published cases of mosaic T14 that addressed some epidemiological aspects of this abnormality. We conducted a literature review and collected information on 194 cases of regular T14 and only two cases of mosaic T14 among 21,082 tested spontaneous abortuses. Thus, the rates of nonmosaic T14 and mosaic T14 were 0.9% and 0.09‰, respectively. Additionally, we identified 76 carriers of mosaic T14, diagnosed prenatally and postnatally. Among them, there were 50 carriers of mosaicism for regular T14, 21 carriers of mosaicism due to unbalanced homologous translocation/isochromosome, and five carriers of mosaicism for unbalanced non-homologous Robertsonian translocation involving chromosome 14. The most significant findings were as follows. i) The unexplained fourfold predominance of the carriers of homologous rearrangement relative to non-homologous translocations, but the occurrence of exceptionally rare homologous rearrangements compared to non-homologous translocations in human populations; also, the ratio between these two types of rearrangements (21 and 28, respectively) differed from that in the carriers of non-mosaic UPD(14) (p < 0.005). ii) Female patients were predominant in all studied groups, irrespective of the type of the trisomic line and parental origin of the euploid cell line; there were 19 male and 57 female cases reported. iii) The differences in the maternal age between carriers of mosaicism for regular T14 with and without maternal uniparental disomy were statistically significant (average age of 35.4 and 29.8 years, respectively; p < 0.05). This is intriguing because of the common mechanism of the formation of biparental and uniparental disomy. Additionally, a complicated reproductive history was noted in 25% of the families.
MIRA Rehab Exergames for Older Male Residents in a Care Home Center in Saudi Arabia: Protocol for a Feasibility Randomized Controlled Trial
Authors: Zougar Mohammad , Todd Chris , McGarrigle Lisa , Stanmore Emma
Published: September 2022

Background

Physical activity leads to improvements in morbidity, mortality, and quality of life, especially when it is progressive, challenging, and regular. There is strong evidence that strength and balance exercises decrease the risk of falling. However, traditional exercises may be tedious and not very motivating for participants. Exergames have been found to increase engagement and enjoyment for older users.

Objective

This study will conduct a feasibility randomized controlled trial (RCT) on the use of MIRA Rehab Exergames among older male residents in a care home setting in Saudi Arabia. A sample of 30 eligible participants will be recruited to meet feasibility study requirements.

Methods

We will recruit 38 residents in the care home who will be randomly allocated to either an intervention or a control group. The intervention participants will perform gamified exercises using the MIRA telerehabilitation platform (30 minutes 3 times per week for 6 weeks). The control group will receive educational advice based on booklets of the Otago exercise program and be encouraged to exercise (30 minutes 3 times per week for 6 weeks). Participants will be assessed at weeks 0, 6, and 12. Assessments will include feasibility measures (eligibility, recruitment and attrition rates, and practicalities of data collection methods) and participant outcome measures (balance, strength, mobility, adherence, quality of life, fear of falling, depression, acceptability, and usability).

Results

Data collection started in November 2021 and ended in March 2022. The study is currently in the data analysis stage, which commenced in May 2022. The findings from this feasibility RCT will be used to design a definitive RCT to test whether the MIRA Rehab Exergame program benefits older people in Saudi Arabia who may not like participating in traditional exercise programs and may be unwilling or unable to leave their homes.

Conclusions

This study will contribute to our understanding of how to recruit in this specific population and provide information to inform the design of a future RCT.

International Registered Report Identifier (IRRID)

DERR1-10.2196/39148
Promoting Self-management and Patient Activation Through eHealth: Protocol for a Systematic Literature Review and Meta-analysis (Preprint)
Authors: Moradian Saeed , Maguire Roma , Liu Geoffrey , Krzyzanowska Monika K , Butler Marcus , Cheung Chantal , Signorile Marisa , Gregorio Nancy , Ghasemi Shiva , Howell Doris
Published: September 2022

BACKGROUND

Major advances in different cancer treatment modalities have been made, and people are now living longer with cancer. However, patients with cancer experience a range of physical and psychological symptoms during and beyond cancer treatment. New models of care are needed to combat this rising challenge. A growing body of evidence supports the effectiveness of eHealth interventions in the delivery of supportive care to people living with the complexities of chronic health conditions. However, reviews on the effects of eHealth interventions are scarce in the field of cancer-supportive care, particularly for interventions with the aim of empowering patients to manage cancer treatment–related symptoms. For this reason, this protocol has been developed to guide a systematic review and meta-analysis to assess the effectiveness of eHealth interventions for supporting patients with cancer in managing cancer-related symptoms.

OBJECTIVE

This systematic review with meta-analysis is conducted with the aim of identifying eHealth-based self-management intervention studies for adult patients with cancer and evaluating the efficacy of eHealth-based self-management tools and platforms in order to synthesize the empirical evidence on self-management and patient activation through eHealth.

METHODS

A systematic review with meta-analysis and methodological critique of randomized controlled trials is conducted following Cochrane Collaboration methods. Multiple data sources are used to identify all potential research sources for inclusion in the systematic review: (1) electronic databases such as MEDLINE, (2) forward reference searching, and (3) gray literature. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for conducting the review were followed. The PICOS (Population, Interventions, Comparators, Outcomes, and Study Design) framework is used to identify relevant studies.

RESULTS

The literature search yielded 10,202 publications. The title and abstract screening were completed in May 2022. Data will be summarized, and if possible, meta-analyses will be performed. It is expected to finalize this review by Winter 2023.

CONCLUSIONS

The results of this systematic review will provide the latest data on leveraging eHealth interventions and offering effective and sustainable eHealth care, both of which have the potential to improve quality and efficiency in cancer-related symptoms.

CLINICALTRIAL

PROSPERO 325582; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=325582

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/38758
EpiTAT – the Epidemiological Tattoo Assessment Tool to assess ink exposure and related factors in tattooed populations for medical research: Cross-sectional validation study (Preprint)
Authors: Foerster Milena , Dufour Lucas , Bäumler Wolfgang , Schreiver Ines , Goldberg Marcel , Zins Marie , Ezzedine Khaled , Schüz Joachim
Published: September 2022

BACKGROUND

The prevalence of decorative tattoos is increasing worldwide. Tattooing is an invasive body art that involves the injection of chemical mixtures into the upper layer of the dermis. Although these mixtures may contain environmental toxins, including known human carcinogens, their long-term health effects are poorly studied. Although epidemiological studies are urgently needed, there is no validated method for assessing tattoo exposure so far.

OBJECTIVE

To develop and validate a method to assess ink exposure in the tattooed population suitable for application in large cohort studies.

METHODS

Three preliminary versions of the EpiTAT (Epidemiological Assessment Tool for Tattooing) using the tattoo measurement unit "hand surface", "credit card" or "body schemes", were randomly filled in by tattooed volunteers in Lyon, France. A validation study was conducted with 97 selected respondents to compare the self-assessment with validation measurements of tattoo surface, color and fill made by trained study personnel. Interclass correlation, Kendall's rank correlation and two-tailed Student's t-tests were used to statistically compare tattoo size, color area and tattoo fill. Participants' comments on the questionnaire were also considered. For quality control of validation measures, digital surface analysis of 62 photographs of selected tattoos was performed via Fiji/ImageJ.

RESULTS

In general, results revealed overestimation of self-assessed compared to validation measures (e.g. mean tattooed body surface 1768 cm2 (SD: 1547) vs. 930 cm2 (SD: 1047; p<0.005) for the “hand surface”), and validation measures to digital image analysis (mean tattoo surface 147 cm2 (SD:303.9) vs 101 cm2 (SD:154.7; p=0.045)). Although the "credit card" approach yielded the most accurate measures for all variables of interest, it had a much lower completion rate (60%; 78/129) compared to "hand surface" (86%; 89/104) and "body patterns" (85%; 90/106). The "hand surface" measured total tattoo size more accurately than the "body schemes" (absolute agreement intraclass correlation coefficients: 0.71 versus 0.64).

CONCLUSIONS

The final version of EpiTAT contains 21 items and uses the "hand surface" as a visual unit of measurement. Likert scales are used to assess color and filling as a proportion of the total tattoo area. Overestimation of tattoo size by self-reporting must be corrected when calculating exposure.
Reducing Clinical Trial Monitoring Resources and Costs With Remote Monitoring: Retrospective Study Comparing On-Site Versus Hybrid Monitoring (Preprint)
Authors: Fu Zhiying , Liu Xiaohong , Zhao Shuhua , Yuan Yannan , Jiang Min
Published: September 2022

BACKGROUND

Clinical research associates (CRAs) monitor the progress of a trial, verify the data collected, and ensure that the trial is carried out and reported in accordance with the trial protocol, standard operating procedures, and relevant laws and regulations. In response to monitoring challenges during the COVID-19 pandemic, Peking University Cancer Hospital launched a remote monitoring system and established a monitoring model, combining on-site and remote monitoring of clinical trials. Considering the increasing digitization of clinical trials, it is important to determine the optimal monitoring model for the general benefit of centers conducting clinical trials worldwide.

OBJECTIVE

We sought to summarize our practical experience of a hybrid model of remote and on-site monitoring of clinical trials and provide guidance for clinical trial monitoring management.

METHODS

We evaluated 201 trials conducted by our hospital that used on-site monitoring alone or a hybrid monitoring model, of which 91 trials used on-site monitoring alone (arm A) and 110 used a hybrid model of remote and on-site monitoring (arm B). We reviewed trial monitoring reports from June 20, 2021, to June 20, 2022, and used a customized questionnaire to collect and compare the following information: monitoring cost of trials in the 2 models as a sum of the CRAs’ transportation (eg, taxi fare and air fare), accommodation, and meal costs; differences in monitoring frequency; the number of monitored documents; and monitoring duration.

RESULTS

From June 20, 2021, to June 20, 2022, a total of 320 CRAs representing 201 sponsors used the remote monitoring system for source data review and the verification of data from 3299 patients in 320 trials. Arm A trials were monitored 728 times and arm B trials were monitored 849 times. The hybrid model in arm B had 52.9% (449/849) remote visits and 48.1% (409/849) on-site visits. The number of patients’ visits that could be reviewed in the hybrid monitoring model increased by 34% (4.70/13.80; P=.004) compared with that in the traditional model, whereas the duration of monitoring decreased by 13.8% (3.96/28.61; P=.03) and the total cost of monitoring decreased by 46.2% (CNY ¥188.74/408.80; P<.001). These differences were shown by nonparametric testing to be statistically significant (P<.05).

CONCLUSIONS

The hybrid monitoring model can ensure timely detection of monitoring issues, improve monitoring efficiency, and reduce the cost of clinical trials and should therefore be applied more broadly in future clinical studies.
Predicting Patient Mortality for Earlier Palliative Care Identification in Medicare Advantage Plans: Features of a Machine Learning Model (Preprint)
Authors: Bowers Anne , Drake Chelsea , Makarkin Alexi E , Monzyk Robert , Maity Biswajit , Telle Andrew
Published: September 2022

BACKGROUND

Machine learning (ML) can offer greater precision and sensitivity in predicting Medicare patient end of life and potential need for palliative services compared to provider recommendations alone. However, earlier ML research on older community dwelling Medicare beneficiaries has provided insufficient exploration of key model feature impacts and the role of the social determinants of health.

OBJECTIVE

This study describes the development of a binary classification ML model predicting 1-year mortality among Medicare Advantage plan members aged ≥65 years (N=318,774) and further examines the top features of the predictive model.

METHODS

A light gradient-boosted trees model configuration was selected based on 5-fold cross-validation. The model was trained with 80% of cases (n=255,020) using randomized feature generation periods, with 20% (n=63,754) reserved as a holdout for validation. The final algorithm used 907 feature inputs extracted primarily from claims and administrative data capturing patient diagnoses, service utilization, demographics, and census tract–based social determinants index measures.

RESULTS

The total sample had an actual mortality prevalence of 3.9% in the 2018 outcome period. The final model correctly predicted 44.2% of patient expirations among the top 1% of highest risk members (AUC=0.84; 95% CI 0.83-0.85) versus 24.0% predicted by the model iteration using only age, gender, and select high-risk utilization features (AUC=0.74; 95% CI 0.73-0.74). The most important algorithm features included patient demographics, diagnoses, pharmacy utilization, mean costs, and certain social determinants of health.

CONCLUSIONS

The final ML model better predicts Medicare Advantage member end of life using a variety of routinely collected data and supports earlier patient identification for palliative care.
Disinfection of virtual reality devices in healthcare settings (Preprint)
Authors: Roberts Scott , Havill Nancy , Flores Rosa , Hendrix II Curtis , Williams Maximillian , Feinn Richard , Martinello Richard , Marks Asher , Murray Thomas
Published: September 2022

BACKGROUND

Virtual reality (VR) devices are increasingly used in healthcare settings. Use between patients has the potential to unintentionally transmit pathogens between patients and/or hospital staff. No standard operating procedure for disinfection exists to ensure safe use between patients.

OBJECTIVE

To determine the efficacy of disinfectants on virtual reality devices in order to ensure safe use in healthcare settings.

METHODS

Three types of bacteria were inoculated onto porous and non-porous surfaces of two VR devices, the Meta Oculus Quest and Meta Oculus Quest 2. Disinfection was performed using either isopropyl alcohol or alcohol-free quaternary ammonium wipes. Quantitative culture was used to assess the adequacy of disinfection. A survey was separately sent out to VR device technicians at other pediatric healthcare institutes to compare methods of disinfection and how they were established.

RESULTS

Both products achieved adequate disinfection of the treated surfaces, however a greater log-kill was achieved on non-porous surfaces than porous surfaces. alcohol performed better than quaternary ammonium on porous surfaces. Survey respondents reported wide variability is disinfection processes with only one person reporting an established standard operating procedure.

CONCLUSIONS

Disinfection can be achieved through use of either isopropyl alcohol or quaternary ammonium products. Porous surfaces showed lesser log-kill rates than non-porous surfaces, indicating use of an added barrier may be of benefit and should be a point of future research. Given the variability in disinfection process across healthcare systems, a standard operating procedure is proposed.
The Next Frontier of Remote Patient Monitoring: Hospital at Home (Preprint)
Authors: Whitehead David , Conley Jared
Published: September 2022

UNSTRUCTURED

Remote patient monitoring (RPM) has shown promise in aiding safe and efficient remote care for chronic conditions; however, its use remains more limited within the hospital at home (HaH) model of care despite a significant opportunity to increase patient eligibility, improve safety, and decrease costs. HaH could achieve these goals by further adopting the 3 primary modalities of RPM (ie, vital sign, continuous single-lead electrocardiogram, and fall monitoring). With only 2 in-person vital sign checks required per day, HaH patient eligibility is currently often limited to lower-acuity cases. The use of vital sign RPM within HaH could better match the standard clinical practice of vital sign checks every 4-8 hours and enable safe care for appropriate moderate-acuity medical and surgical floor-level patients not traditionally enrolled in HaH. Robust, efficient collection of more frequent vital signs via RPM could expand patient eligibility for HaH and create a digital health safety net that enables high quality care. Similarly, our experience at Massachusetts General Hospital has demonstrated that appropriate use of continuous single-lead electrocardiogram RPM can also expand HaH enrollment, particularly for patients with acute decompensated heart failure. Through increasing enrollment of patients in HaH, RPM stands to enable more patients to reap the potential safety benefits of home hospitalization, including decreased rates of delirium and hospital-acquired infections, and better avoid aspects of posthospital syndrome. Furthermore, instituting fall detection RPM allows care teams to further HaH patient safety during their episode of acute care and develop enhanced mitigation strategies to avoid falls post home hospitalization. RPM also has the potential to assist HaH in achieving greater economies of scale and decreasing direct variable costs. By expanding HaH eligibility, RPM could enable HaH programs, which have traditionally operated under capacity, to care for a larger census and decrease allocated fixed costs per hospitalization. Additionally, RPM for HaH could further optimize hybrid in-home and remote nurse or physician evaluations, decreasing costs on a per-episode basis by up to an estimated 3.5%. Overall, RPM holds great promise to increase patient eligibility and patient safety while decreasing costs. However, it is in its infancy in achieving its potential to advance the HaH model of care; further research and experience that inform operational and technical as well as policy considerations are needed.
Applying A* Path Planning Algorithm Based on Modified C-Space Analysis
Authors: Raheem Firas A. , Hussain Asmaa A.
Published: September 2022

In this paper, a modified derivation has been introduced to analyze the construction of C-space. The profit from using C-space is to make the process of path planning more safety and easer. After getting the C-space construction and map for two-link planar robot arm, which include all the possible situations of collision between robot parts and obstacle(s), the A* algorithm, which is usually used to find a heuristic path on Cartesian W-space, has been used to find a heuristic path on C-space map. Several modifications are needed to apply the methodology for a manipulator with degrees of freedom more than two. The results of C-space map, which are derived by the modified analysis, prove the accuracy of the overall C-space mapping and construction, and then a successful and guaranteed path from a start to goal configuration has been obtained without any collision probability. The results had been achieved by (Matlab R2015a) software, which run on Intel (R) Core (TM) i3-3120M CPU.
Analysis the Surface Morphology of the Porous Media by using Atomic Force Microscope technique
Authors: Al-Zaidi Bashir Y. Sherhan
Published: September 2022

An atomic force microscope (AFM) technique is utilized to investigate the polystyrene (PS) impact upon the morphological properties of the outer as well as inner surface of poly vinyl chloride (PVC) porous fibers. Noticeable a new shape of the nodules at the outer and inner surfaces, namely "Crater nodules", has been observed. The fibers surface images have seen to be regular nodular texture at the skin of the inner and outer surfaces at low PS content. At PS content of 6 wt.%, the nodules structure was varied from Crater shape to stripe. While with increasing of PS content, the pore density reduces as a result of increasing the size of the pore at the fiber surface. Moreover, the test of 3D-AFM images shows that the roughness of both surfaces of fibers seems to be decreased with PS content. Alternatively, the fibers pure water permeability (PWP) has been declined with decreasing of fiber roughness.
The effect of replacing soybean meal with Fava bean seeds in daily ration of Lebanese Baladi goat kids and Awassi sheep lambs: 1- Body performance
Authors: Yaacoub Rami
Published: September 2022

The aim of the study was to investigate the partial and complete substitution of imported soybean meal (SBM) with Fava bean seeds (FBS) in Awassi male lambs (S) and local Baladi goat kids (G) rations and the consequences on body performance. Fifteen growing lambs and 15 growing kids, with an initial bodyweight of 23.09 and 14.90 kg with 100 days of age, respectively, were fed cotton-seed meal (CSM), wheat bran and corn-based diet supplemented with protein legume sources, 75% FBS :25% SBM (S75 & G75), 0% FBS :100% SBM (S100 and G100-positive control) and 100% FBS :0% SBM (SC0 & GC0- negative control). Awassi lambs of all groups had comparable average feed intake (FI) accumulating between 43.9 and 49.4 kg/head and live body weight gain (LBWG) between 6.5 and 10.9 kg/head. Whereas local Baladi goat kids attained a cumulative LBWG levels of 5.7 and 3.96 kg/head and cumulative FI of 28.2 and 29.7 kg/head. Feed conversion ratio (FCR) for lambs attained the best results in group S50 (3.92) and the least in S100 (6.82) and for kids 7.14 in G100 and 5.25 in G75 groups. Feeding group S50 with 50% FBS and 50% SBM in based-ration gave more profit 17.2% than all other groups in comparison with SC0. On the other hand, G75 gave the highest profit by 19.15% in goat kids. Most notably, omitting soybean meal with or without additional protein legume as fava bean seeds replacements resulted in comparable high-body performance level.
Comprensión de oraciones relativas con predicados psicológicos en español
Authors: Murujosa Marisol , Gattei Carolina Andrea , Shalom Diego Edgar , Sevilla Yamila Alejandra
Published: September 2022

En este trabajo se llevó a cabo un estudio de comprensión auditiva de oraciones relativas con predicados psicológicos (p. ej. gustar) y de actividad (p. ej. sonreír) en español de Argentina. Los resultados muestran que las relativas de sujeto con predicados de actividad fueron más fáciles de procesar que las de objeto. En cambio, las relativas de objeto con predicados psicológicos fueron más sencillas que las de sujeto. Estos resultados argumentan a favor de propuestas sobre el procesamiento de asimetrías sujeto-objeto dependientes de las configuraciones estructurales de las oraciones, como minimidad relativizada por rasgos (Rizzi, 2004), y son consistentes con el hecho de que no todas las lenguas se comportan de la misma manera durante la compresión de oraciones relativas.
Inglés II
Authors:   FES Aragón UNAM, Sosa Aguilar Alonso Abraham
Published: September 2022

Este texto ayuda a emplear el idioma inglés en un nivel A1-A2 del Marco Común Europeo (nivel principiante – pre intermedio) para expresar acciones en pasado, comparar objetos, personas o cosas, planes a futuro y experiencias de vida mediante la explicación gramatical y ejemplos significativos de los mismos.
Content analysis of cell division concepts in Senior High School Biology textbooks
Authors: Lopez Eva Niña B. , Maraño Chris Mae B. , Origenes Ritchelle W. , Pizaña Aylene D. , Salmo Josephine M. , Picardal Jay P.
Published: September 2022

Content and accuracy evaluation of textbooks is important as it provides quality assurance to both teachers and learners, especially in the new normal where modular instruction is used. This research aimed at evaluating the biology textbooks used by Senior High School STEM Science teachers (n=15) in content, presentation, and learning strategies. Content analysis and Collaizzi’s descriptive phenomenology approach were employed in this study. The results showed that all evaluated textbooks have unique, distinct content, presentation, and learning strategies. Most topics were also aligned with the minimum curriculum requirement for SHS STEM, but topics such as cyclin-dependent kinases (CDKs) and control checkpoints were not discussed in some books. Learning outcomes were not indicated in some books, and few textbooks did not reach synthesis and evaluation level. However, a comparative approach of cell division across the 5-kingdom system is observed but not explained well, and some misleading statements in the cell division mechanism were present. Considering that cell division precedes the discussion of cancer cell division and metastasis, content enrichment through learner-friendly visuals and diagrams is recommended to facilitate learning, improve retention, and avoid misconceptions.
Metacognitive skill profile of biology education students at institute of teachers’ education in South Sulawesi, Indonesia
Authors: Adiansyah Romi , Amin Astuti Muh. , Ardianto A. , Yani Ahmad
Published: September 2022

Metacognitive skills are one of the abilities required in the twenty-first century, to achieve independent learning. However, these skills still need to review whether these skills have been empowered by educators, particularly in universities. This research was aimed at determining the metacognitive skill profile of Biology Education students at the Institute of Teachers’ Education in South Sulawesi, Indonesia. This research used a descriptive quantitative method. The population of this research was all the students of the Biology Education Study Program at the non-state Institute of Teachers’ Education in South Sulawesi. The samples of this research were 356 Biology Education students in the second semester who programmed the Environmental Science course in the 2020/2021 academic year. The instrument used in this research was an essay test to measure students’ metacognitive skills in the Environmental Science course. The results of the data analysis indicate that the students’ metacognitive skills are in the category of undeveloped as much as 89.27%. Therefore, some efforts to improve students’ metacognitive skills are required by those institutes through the implementation of a learning model which can empower the metacognitive skills of the prospective Biology teacher students.
Acrostic Conversation: Horace, Ode I 18
Authors: Adkin Neil
Published: September 2022

This article argues that gamma-acrostical disce in Horace’s Ode I 18 (ll. 11–15) alludes to the land-confiscatory acrostics recently identified in Virgil’s Eclogues (I 5–8; VI 14–24; IX 34–38). Horace has carefully signposted his acrostical intent. Virgil himself interfaces with this Horatian cryptography by means of other acrostics of his own. The result is an ‘acrostic conversation’.
La investigación un proceso de alianzas para el desarrollo regional
Authors:   Vicerrectoría de Investigaciones, Innovación y Extensión, Correa Vallejo Martha Judith , López Isaza Giovanni Arturo , Escobar Mejía Andrés , Redondo Ramírez Marlen Isabel , Holguin Londoño Mauricio otros
Published: September 2022

El presente libro lleva como título “La investigación un proceso de alianzas para el desarrollo regional”, el cual se ha llevado a cabo como resultado del IV encuentro de investigadores del departamento de Risaralda realizado en noviembre 2019, en el cual se presentaron las últimas investigaciones realizadas en las diferentes instituciones del departamento que hacen parte de la Mesa de Investigaciones del departamento; resultados de investigaciones de gran interés en diferentes campos del conocimiento como son las Ciencias Agrícolas , Ciencias de la salud, Ciencias sociales y Ciencias de la tecnología y la información.