bluuebunny/crossref_metadata_2025 huggingface dataset:
Kebijakan Penal dan Non Penal Dalam Penanganan Tindak Pidana
Authors: Vishnu Andhika , Fuad Fokky , Machmud Aris
Published: January 2024

Semakin maraknya kekerasan yang bertendensi kriminal di antara perguruan silat di Madiun semakin mengkhawatirkan dan telah menjadi keresahan bagi masyarakat umum, sehingga diperlukan tindakan yang efektif baik secara preventif maupun represif dalam menangani kekerasan yang terus berulang. Tujuan penelitian ini adalah untuk mengkaji efektivitas penerapan kebijakan pidana dalam kekerasan yang berulang antar perguruan silat di Madiun. Metode penelitian menggunakan yuridis empiris yang menggabungkan penelitian normatif dengan empirisme hukum melalui pendekatan deskriptif analitis. Konflik sosial dalam perguruan pencak silat di Madiun dapat dilakukan melalui pemanfaatan kearifan budaya lokal, di mana sebagai ageman (pedoman) dalam kehidupan bermasyarakat yang mengedepankan aspek norma sosial yang sudah disepakati oleh masyarakat setempat. Melalui pendekatan kebijakan penal jauh lebih efektif dibandingkan dengan pendekatan kebijakan non penal terhadap tindakan kekerasan yang berulang yang terjadi dalam perguruan silat di Madiun.
Konsep Materialitas Dalam Aksi Korporasi Anak Cucu BUMN Berdasarkan Undang-Undang Perseroan Terbatas
Authors: Handayani Ika Apri , Suartini Suartini , Fuad Fokky
Published: January 2024

Materialitas merupakan satuan batasan kewenangan dari direksi untuk melakukan aksi korporasi dalam menjalankan usaha sehingga direksi dapat mempertimbangkan tindakan mana yang harus mendapatkan persetujuan RUPS dan mana yang hanya diputuskan melalui rapat direksi ataupun persetujuan komisaris. Tujuan dari penelitian ini adalah untuk mengkaji konsep materialitas diterapkan dalam aksi korporasi perusahaan anak cucu BUMN berdasarkan Undang-Undang Perseroan Terbatas. Metode penelitian yang digunakan adalah yuridis normatif dengan pendekatan peraturan perundang-undangan serta metode multidisiplin dengan melibatkan bidang ilmu akuntansi dan hukum dalam menganalisis sumber hukum yang dikumpulkan, diklasifikasikan dan selanjutnya ditarik kesimpulan. Adapun hasil dari penelitian ini menunjukkan bahwa materialitas merupakan suatu bentuk pembatasan direksi dalam melakukan aksi korporasi yang sesuai dengan tata kelola yang baik dengan mempertimbangkan fiduciary duty dan itikad baik sehingga dapat menjamin keberlanjutan kinerja korporasi, serta membebaskan direksi dari tanggung jawab pribadi apabila terjadi kerugian, karena semua aksi korporasi sudah mendapatkan persetujuan RUPS dan benar-benar digunakan untuk kepentingan korporasi.
Pertanggungjawaban Pidana Bagi Pelaku Tindak Pidana Dengan Gangguan Kejiwaan Menurut Ketentuan Hukum Positif
Authors: Ida Orintina Vavinta , Suryawati Nany
Published: January 2024

Mental disorder merupakan kondisi kesehatan yang mempengaruhi pemikiran, perasaan, perilaku dan suasana hati. Pertanggungjawaban pidana bagi orang dengan gangguan mental diatur dalam Pasal 44 KUH Pidana, namun ketentuan ini tidak menjelaskan batasan-batasan yang tidak dapat dijelaskan dari keadaan seseorang, sehingga dalam hal ini harus diketahui hubungan gangguan kejiwaan dengan aktivitas yang dapat dimintai pertanggungjawaban pidana. Penulisan ini menggunakan metode penulisan normatif yang didasarkan pada pendekatan undang-undang dan pendekatan kasus. Berdasarkan hasil penelitian pengaturan hukum terhadap orang dengan gangguan mental yang telah diatur dalam Pasal 44 ayat (1) dan (2) KUH Pidana. Hukuman pidana tidak dapat dijatuhkan kepada pelaku kejahatan dengan gangguan mental, dikarenakan masih adanya kekaburan dalam Pasal 44 KUH Pidana. Hukum di Indonesia telah mengatur dan menetapkan bahwa sebagaimana seseorang dapat dikatakan dewasa serta dapat bertanggung jawab terhadap tindakan hukum yang dia lakukan, sehingga hakim dapat menjatuhkan hukuman sesuai yang telah diatur oleh peraturan perundang-undangan yang berlaku.
Ruptura prematura de membranas ovulares
Authors: Rodríguez Rafael , Pérez Dajimze
Published: January 2024

La ruptura prematura de las membranas ovulares se define como la pérdida de la integridad del amnios y corion antes del inicio del trabajo de parto, afecta el 3 % de los embarazos, causa un tercio de los partos pretérminos, los cuales ocupan el 10,49 % de los nacimientos y es el origen de altos índices de morbimortalidad perinatal. En la actualidad, el manejo de esta patología se orienta principalmente en evitar los factores de riesgo, hacer un diagnóstico adecuado, determinar la edad gestacional en que ocurre, realizar el monitoreo exhaustivo del bienestar materno-fetal y en decidir el momento idóneo de finalización de la gestación para minimizar sus complicaciones. Debido a la compleja y lábil estructura histológica de las membranas ovulares, se ha dejado a un lado el tratamiento directo de la entidad el cual sería sellar o reparar el defecto en sí. En los últimos años, numerosos estudios y protocolos clínicos de prestigiosos centros asistenciales han servido como guía para el manejo de esta entidad, pero en muy pocos se observa una terapia destinada a la reparación de dichas membranas o en sellar tal defecto. Las evidencias científicas demuestran que la regeneración y reparación de las membranas es lenta y compleja y los tratamientos propuestos para reparar o sellar su defecto no han gozado de la aceptación científica para su aprobación, sin embargo, el uso del parche hemático transvaginal endocervical autólogo luce como una alternativa terapéutica prometedora.
Aspectos metodológicos de la Encuesta Nacional de Condiciones de Vida en Venezuela
Authors: Vásquez Oscar , Perdomo Irma
Published: January 2024

La presente revisión surge dada la importancia otorgada a la Encuesta Nacional de Condiciones de Vida (ENCOVI) de Venezuela, la edición de dicha encuesta proporciona información representativa de la situación económica, social y de salud de los hogares del país. Los resultados de la encuesta permiten a investigadores y expertos analizar y comprender la magnitud de la crisis en sus diversos aspectos y sus efectos sobre la población y las condiciones de vida, lo que la convierte en una herramienta esencial para entender los problemas que enfrenta la población de Venezuela y la forma de abordarlos de manera efectiva. La ENCOVI proporciona información útil, no solo, a la sociedad civil y Organizaciones No Gubernamentales (ONGs), también a instituciones gubernamentales, al ser divulgada a través de medios de comunicación, aportando importantes insumos para el abordaje de los problemas públicos y los desafíos en cada sector, permitiendo comprender las condiciones de vida en los hogares venezolanos. La investigación se basa en un diseño bibliográfico-documental, efectuando para ello 6 fases constituidas por: búsqueda, compilación, revisión, selección, organización y examen sistemático. El objetivo es describir aspectos metodológicos utilizados en la encuesta nacional de condiciones de vida desde el 2014 hasta el 2022.
Profilaxia de úlcera por estresse em pacientes internados em unidades de terapia intensiva
Authors: Cazumbá Larissa Gomes
Published: January 2024

Objetivo: Avaliar a profilaxia de úlcera por estresse em pacientes internados em unidades de terapia intensiva (UTIs) de um hospital geral da Bahia. Métodos: Trata-se de um estudo de corte transversal descritivo, sendo  a amostra constituida por prontuários de pacientes internados em Unidades de Terapia Intensiva de um hospital geral da Bahia, no período de julho a dezembro de 2022. Foram obtidos dados sobre o perfil clínico dos pacientes, como diagnóstico médico e indicação para profilaxia de úlcera por estresse, além de dados sociodemográficos. Resultados: Foram analisados 111 prontuários médicos. O principal motivo encontrado para o uso da profilaxia de UE foi a ventilação mecânica por mais de 48 horas, constituindo 23,42% dos casos. 59,45% dos pacientes apresentaram alto risco para o desenvolvimento de úlcera por estresse, sendo que a  prevalência de prescrição para profilaxia de úlcera por estresse nas UTIs avaliadas foi de 58,55%. Observou-se a presença do uso indevido da profilaxia em apenas 2,7% dos casos. Em relação aos medicamentos mais utilizados, observou-se a predominância do pantoprazol (52,25%). Conclusões: A profilaxia para úlcera por estresse é largamente utilizada nas Unidades de Terapia Intensiva da instituição analisada e, embora não tenha sido constatado uso irracional da profilaxia de úlcera por estresse, é evidente a importância de estabelecer um protocolo clínico que forneça orientações apropriadas para a prescrição dos medicamentos profiláticos.

Palavra-chaves: Profilaxia.Úlcera péptica.Mucosa Gástrica.
Rescue of ancestral knowledge: Linkage Project, Faculty of Pedagogy Universidad Luis Vargas Torres-Esmeraldas
Authors: Hurtado Toral Carmen Karina , Toala Ponce Santa Rocío , Posso Martínez Rosa Romelia
Published: January 2024

The objective of this outreach project, developed at the Faculty of Pedagogy-University Luis Vargas Torres in Esmeraldas, is to rescue and preserve ancestral knowledge of the Afro-Smeraldas culture, which has a deep-rooted cultural tradition, whose knowledge, transmitted through generations, is currently threatened to be lost into oblivion due to the lack of recognition and the advances of globalization. The objective is to promote its preservation and appreciation, while training university students for the development of pedagogical practices linked to society. The methodology of action research, empirical, with a qualitative approach of bibliographic review, allowed gathering the information to present this article; establishing as a result the valuation of the Afro-Smeraldean culture in the university community, allowing to acquire an understanding of the importance of cultural diversity, equity and inclusion. Finally, this linkage project is significant for the promotion and preservation of Afro-Esmeraldean ancestral knowledge, contributing to the educational and cultural development of the province of Esmeraldas, strengthening the relationship and transmission of knowledge between academia and society; therefore, the continuity of this initiative is essential to ensure the preservation of this invaluable cultural treasure for future generations.
Mannose-Binding Lectin Gene Polymorphism versus Microbial Virulence in the Pathogenesis of Vulvovaginal Candidiasis and Recurrent Vulvovaginal Candidiasis
Authors: Wali Iman , Haggag Eman M. , Awad Alaa R. , El-Sharkawy Mohammad A. , Sallam Marwa K.
Published: January 2024

BACKGROUND: Vulvovaginal candidiasis (VVC) is one of the most common infections affecting women. AIM: This study aimed to determine MBL2 polymorphism frequency among females with VVC together with assessment of Candida virulence attributes in the pathogenesis of it. METHODS: Fifty Egyptian patients and 50 controls were included in the study. Vaginal swabs were cultured to identify Candida spp. D-ARMs were used to determine MBL2 polymorphism. RESULTS: Cases with VVC revealed Candida albicans 37(74%) and non-Albicans Candida (NAC) 13 (26%) with a significant difference between C. albicans and NAC esterase and phospholipase. Thirty C. albicans isolates (81.1%) possessed three or more virulence factors, compared to only four NAC (30.8%) (p = 0.002). As regards MBL2 polymorphism, the X allele was found to be significantly high in cases than in controls (p ≤ 0.001). B allele on codon 54 and L allele on promoter region was more in cases. Other haplotypes were more in cases than controls with a significant difference for LXQB and HXQB. HXPB and LXQB were detected among recurrent VVC (RVVC) cases more than VVC cases. CONCLUSION: RVVC appears to be a multi-factorial disorder; hence, treatment should be individualized. Recombinant MBL may be considered in the future treatment of RVVC in the case of associated genetic MBL2 polymorphism.
Hypericum liboense (Hypericaceae), a new species from Guizhou, China
Authors: Wu Tian-Rou , Xu Jian , An Ming-Tai , Yu Jiang-Hong , Liu Feng , Chen Zheng-Ren
Published: January 2024

Hypericum liboense M.T.An & T.R.Wu, sp. nov. (Hypericaceae) is a newly described species found in the Maolan National Nature Reserve of Guizhou Province, where it grows in rocky habitats without soil on karst mountain tops. In this study, key morphological characters were compared between the new species and the other known Hypericum species of Hypericaceae. DNA sequences were extracted from the leaves of the new species, with nuclear gene sequences (ITS) generated to reconstruct phylogenetic trees and describe its phylogenetic position in relation to other species of Hypericum. Our results show that the proposed new species has the typical characteristics of the genus Hypericum in morphology being similar to Hypericum monogynum, but differing in its sessile and semi-clasped leaves, long elliptical to long circular leaf blades, thickly papery to thinly leathery, with entire and wavy leaf margins. The abaxial side of the leaves is covered with white powder, giving them a grey-white appearance. The main lateral veins of the leaves are 8–15-paired, and the midvein on both sides is convex. The main lateral veins and midvein branch are conspicuous, with tertiary venation forming a network on the leaf surface and appearing prominently sunken. The inflorescences are 1–3-flowered, with a large calyx and conspicuous veins. The molecular phylogenetic analysis (PP = 1.00) provided substantial evidence for the proposition of H. liboense as a new species within Hypericum. Morphological and molecular evidence is presented, corroborating the proposition of the new species, including a comprehensive account of the distinctive morphological attributes of H. liboense, along with its key distinguishing features from similar species.
Learning cooperative strategies in StarCraft through role-based monotonic value function factorization
Authors: Han Kun , Jiang Feng , Zhu Haiqi , Shao Mengxuan , Yan Ruyu
Published: January 2024

StarCraft is a popular real-time strategy game that has been widely used as a research platform for artificial intelligence. Micromanagement refers to the process of making each unit perform appropriate actions separately, depending on the current state in the the multi-agent system comprising all of the units, i.e., the fine-grained control of individual units for common benefit. Therefore, cooperation between different units is crucially important to improve the joint strategy. We have selected multi-agent deep reinforcement learning to tackle the problem of micromanagement. In this paper, we propose a method for learning cooperative strategies in StarCraft based on role-based montonic value function factorization (RoMIX). RoMIX learns roles based on the potential impact of each agent on the multi-agent task; it then represents the action value of a role in a mixed way based on monotonic value function factorization. The final value is calculated by accumulating the action value of all roles. The role-based learning improves the cooperation between agents on the team, allowing them to learn the joint strategy more quickly and efficiently. In addition, RoMIX can also reduce storage resources to a certain extent. Experiments show that RoMIX can not only solve easy tasks, but it can also learn better cooperation strategies for more complex and difficult tasks.
Isolating switch state detection system based on depth information guidance
Authors: Xu Hui , Zhao Xinyang , Yin Qiyun , Dou Junting , Liu Ruopeng , Wang Wengang
Published: January 2024

This study addressed the critical role of isolating switches in controlling circuit connections for the stable operation of the substation. Our research introduced an innovative state detection system that utilized depth information guidance, comprising a controllable pan-tilt mechanism, a depth camera, and an industrial computer. The software component employed a two-stage strategy for precise isolating switch detection. Initially, the red green blue with depth (RGB-D) saliency network identified the approximate area of the isolating switch target. Subsequently, a fully connected conditional random field was applied to extract accurate detection results. The real-time state of the isolating switch was determined based on the geometric relationship between its arms. This approach enhanced the accuracy of isolating switch detection, ensuring practical applicability in engineering scenarios. The significance of this research lies in its contribution to advancing isolating switch monitoring through depth information guidance, promoting a more robust and reliable power system. The key improvement is implementing a two-stage strategy, combining RGB-D saliency analysis and conditional random field processing, resulting in enhanced accuracy in isolating switch detection. As validated through extensive experiments, the proposed system's successful application in practical engineering underscores its effectiveness in meeting the accuracy requirements for isolating switch detection and state detection. This innovation holds promise for broader applications in power systems, showcasing its potential to elevate the reliability and efficiency of electrical networks. Code of the proposed system is available at: https://github.com/miaomiao0909/Isolating-Switch-Detection/tree/master.
Brain-derived neurotrophic factor (BDNF) in chronic pain research: A decade of bibliometric analysis and network visualization
Authors: Ismail Che Aishah Nazariah , Zakaria Rahimah , Azman Khairunnuur Fairuz , Shafin Nazlahshaniza , Bakar Noor Azlina Abu
Published: January 2024

Chronic pain research, with a specific focus on the brain-derived neurotrophic factor (BDNF), has made impressive progress in the past decade, as evident in the improved research quality and increased publications. To better understand this evolving landscape, a quantitative approach is needed. The main aim of this study is to identify the hotspots and trends of BDNF in chronic pain research. We screened relevant publications from 2013 to 2022 in the Scopus database using specific search subject terms. A total of 401 documents were selected for further analysis. We utilized several tools, including Microsoft Excel, Harzing's Publish or Perish, and VOSViewer, to perform a frequency analysis, citation metrics, and visualization, respectively. Key indicators that were examined included publication growth, keyword analyses, topmost influential articles and journals, networking by countries and co-citation of cited references. Notably, there was a persistent publication growth between 2015 and 2021. “Neuropathic pain” emerged as a prominent keyword in 2018, alongside “microglia” and “depression”. The journal Pain® was the most impactful journal that published BDNF and chronic pain research, while the most influential publications came from open-access reviews and original articles. China was the leading contributor, followed by the United States (US), and maintained a leadership position in the total number of publications and collaborations. In conclusion, this study provides a comprehensive list of the most influential publications on BDNF in chronic pain research, thereby aiding in the understanding of academic concerns, research hotspots, and global trends in this specialized field.
Sobre el trímetro yámbico escazonte de Catulo. Estructuras estróficas
Authors: Valverde Abril Juan Jesús
Published: January 2024

Las características que definen el uso que Catulo hace del trímetro yámbico escazonte se han explicado tradicionalmente a partir de la actualización de los modelos griegos obrada por el poeta romano. Sin embargo, Catulo empeña en no pocas ocasiones su capacidad creativa para dotar a esta forma métrica de rasgos originales, convirtiéndola en un medio adecuado para la experimentación literaria. Así, por ejemplo, la división temática de los poemas suele ir acompañada de una estructuración estrófica, definida por la repetición de patrones métricos dentro del poema. Ello, que ya de por sí es importante para comprender la creación poética catuliana en la sofisticación que le es propia, puede ayudar a dilucidar también otras cuestiones, como el establecimiento de una cronología relativa para la composición de estas piezas, o incluso a solventar algunos problemas en la fijación del texto.
The Impact of Implementing a Moodle Plug-in as an AI-based Adaptive Learning Solution on Learning Effectiveness: Case of Morocco
Authors: Ezzaim Aymane , Dahbi Aziz , Haidine Abdelfatteh , Aqqal Abdelhak
Published: January 2024

This article presents feedback on the implementation of an Artificial Intelligence-based adaptive learning Moodle plugin aimed at enhancing the engagement levels and academic performance of 102 Moroccan high school students. The primary objective of this study was to assess and compare the performance of students utilizing the adaptive learning system with those employing conventional learning methods. To guarantee the efficacy of this approach, a participant satisfaction survey and a comprehensive summative evaluation were conducted, revealing the positive impact of AI-based adaptive learning on the participants. The results of this study highlight the potential benefits of integrating AI-driven adaptive learning into high school computer science curricula, emphasizing how it may raise student engagement and academic performance. These results strengthen the determination to use this teaching methodology with students in future educational activities.
Students’ Perception towards Online Learning across Multiple Disciplinary Courses in India—A Qualitative Analysis
Authors: Lakshmi Devasena C  , Shubhangi V Urkude
Published: January 2024

Online learning has become essential to the teaching and learning approach during the pandemic. Due to its enormous benefits, online or e-learning can be sustained. The acceptability of online or e-learning depends on the student’s perception and the availability of infrastructure. Data from various streams and age groups has been collected from students in different institutions. After collecting the data, this research incorporates descriptive statistics for a thorough analysis and utilizes the Chi-square test to provide scientific evidence. This study finds that the majority of final-year undergraduate and postgraduate students support online education. The student’s economic status affects their preference for online or e-learning. Having a smart device and internet access also influence the decision to pursue online or e-learning. Gender is positively associated with access to Internet facilities and has a cascading effect on preferences for online or e-learning. Female students prefer online classes but require additional internet resources. Higher education institutions could enhance their online course offerings by targeting specific groups, such as female students for postgraduate programs, if they could better understand their preferences. Even though some existing studies in the literature have examined the Indian scenario to understand the factors influencing the adoption of online education, none of these studies have considered the fundamental need for online or e-learning. Moreover, the preferences were not studied based on different demographics. This research work has collected and utilized data from various educational disciplines across multiple institutes, marking the first endeavor of its kind in the literature.
Optimized Strategy in Cloud-Native Environment for Inter-Service Communication in Microservices
Authors: Weerasinghe Sidath , Perera Indika
Published: January 2024

Cloud computing has become a prominent technology in the software development industry. The term “cloud-native” is derived from cloud computing technologies and refers to the development and deployment of applications in a cloud environment. In the software industry, most enterprise-grade software buildings use the microservice architecture and cloud natively, ultimately leading to an expansive development in the software development framework. Microservices are deployed in a distributed environment and function as independent services. However, they need to communicate with each other in order to fulfill the functional requirement. Additional latency will be introduced when communicating with other services. Hence, it will impact the overall application response time and throughput. This research proposes a solution for the aforementioned problem in the cloud-native environment. A Request-response-based TCP communication solution has been developed and tested in the cloud-native, containerized environment. Experimental results showed that the turnaround time of the proposed solution is shorter than that of traditional HTTP communication methods. Furthermore, the results summarize that both vertical and horizontal scaling are improving the overall performance of the systems performance in terms of response time. Conclusively, the proposed solution improved the microservice performance and preserved the existing cloud-native qualities, such as scalability, maintainability, and portability.
Effectiveness of an E-learning System for Emergency Signs and CPR Emergency Preparedness in Marathon Events: A Comparative Study
Authors: Homla Pipitton , Ariya Pakinee , Worragin Perasuk , Niemsup Supicha , Puritat Kitti , Intawong Kannikar
Published: January 2024

This study investigates the implementation, effectiveness, and impact of a unique e-learning system designed specifically for emergency signs and cardiopulmonary resuscitation (CPR) emergency preparedness in marathon events. Our approach introduces the first e-learning system specifically designed for marathon events. It delivers engaging content, including infographic stories, expert lectures, and interactive modules, to provide registered runners with comprehensive knowledge of first aid and emergency signs for CPR. To evaluate the e-learning application, we conducted a comparative experiment during the CMU (Chiang Mai University) marathon with 9,761 participants. We used pre- and post-tests, as well as a survey questionnaire. The results showed significant improvements in participants’ CPR knowledge across all educational backgrounds. The integration of e-learning into the registration process contributed to a safer marathon environment, as participants felt more confident in handling emergencies. Approximately 85% of participants expressed a willingness to recommend the e-learning system. This increased confidence among participants in handling emergencies benefits both runners and marathon organizers by enhancing safety measures and emergency response during events. In conclusion, our findings strongly support the integration of e-learning into the registration process for marathon events. Recommendations based on our research include providing comprehensive guidelines for other marathon events, instilling stakeholder confidence, and emphasizing the suitability of e-learning for medium- to largescale events. However, caution is advised for smaller events due to potential complexities and costs. Additionally, we suggest limiting the validity of e-certificates to ensure that participants have up-to-date CPR knowledge.
Farmers vs middle class. Social structure in peri-urban areas
Authors: Zwęglińska-Gałecka Dominika
Published: January 2024

The main subject of the article is process of rural gentrification. It shapes the rural social structure, and thus causes social, economic and cultural changes. Recent analyses conducted in Poland (based on the index of rural gentrification) indicate that this process is most advanced in rural peri-metropolitan areas. They are the optimal place to observe the transformations taking place as a result of rural gentrification process. In the article special attention will be paid precisely to farmers as a segment of the social structure. Their characteristics resulting from demographic and socio-professional differentiation in two types of counties (intensively gentrified and those in which the process of rural gentrification does not occur) will be discussed. The objective of this research is to elucidate the dynamics of agriculture and the farming community within the framework of the rural gentrification phenomenon. The analysis will be based on existing data (publicly available databases in, among others, the Central Statistical Office and the database of the “Social Diagnosis 2015” survey).
L’ombre au tableau : ce que l’art britannique (ne) dit (pas) de la souffrance animale
Authors: Tholoniat Yann
Published: January 2024

L’art britannique est réputé pour ses peintres animaliers depuis le XVIIIe siècle. La peinture animale a évolué selon les demandes, en passant notamment de représentations de chasses à courre et de courses d’animaux d’abord, dont George Stubbs est le principal exemple, à des portraits animaliers ensuite, à l’époque victorienne, avec Edwin Landseer. S’ajoute à cela la tendance de l’esprit des Lumières à explorer les ressorts de la nature – et d’utiliser les animaux dans ce but : le tableau de Wright, An Experiment on a Bird in the Air-Pump (1768), illustre cet aspect. Les animaux sont réduits au silence par les humains : ces derniers rechignent en effet à considérer que les animaux communiquent et expriment des émotions personnelles. De plus, la peinture occidentale est un art dans lequel la parole, ou la communication, passe essentiellement par la mise en scène dramatique et la symbolisation. Au xixe siècle, les peintres préraphaélites utilisent les animaux dans une perspective allégorique, comme le montre bien The Scapegoat de William Holman Hunt. À la fin du xxe siècle, Damien Hirst essaya d’apaiser les polémiques suscitées par ses morceaux d’animaux conservés dans du formol en attirant l’attention sur le massacre des vaches à l’époque de la pandémie due à la maladie de Creuzfeldt-Jakob. En étudiant l’évolution des pratiques artistiques en Grande-Bretagne, nous nous interrogerons sur ce déni dans l’art britannique, qui, paradoxalement, était la souffrance animale dans le geste même de représenter des animaux non humains.
Discours et langages animaux dans la littérature française du début du xxe siècle à l’entre-deux-guerres. Une approche zoopoétique
Authors: Picard Nicolas
Published: January 2024

Au début du vingtième siècle et durant l’entre-deux-guerres prédomine en littérature, en science, en philosophie, le paradigme anthropocentriste issu du cartésianisme et des conceptions réductionnistes de la vie animale. À cette époque, la littérature française, toutefois, à travers toute une variété de textes animaliers, configure le sujet animal dont le vécu psychique, les capacités émotionnelles, cognitives et langagières sont pensés et imaginés. Je m’intéresse dans cet article, dans une perspective zoopoétique, aux enjeux zoologiques, philosophiques et éthiques des discours et langages animaux de ces textes littéraires (essais, romans, portraits, contes…). Je me penche en particulier sur les origines et la préhistoire du langage animal, sur la pertinence de sa comparaison avec le langage articulé humain, sur le dialogisme que les discours animaux mettent en œuvre et sur le fondement d’une éthique écologique de la cohabitation entre bêtes et humains.
Reconstruire le point de vue animal. Retour sur un atelier de réécriture à l’université
Authors: Bessonnet Jodie Lou
Published: January 2024

Cet article présente la mise en œuvre à l’université d’un atelier d’écriture sur le point de vue animal afin d’appréhender la place et la forme que peuvent prendre les études animales dans les cursus universitaires, ainsi que la richesse des apprentissages pluridisciplinaires qu’elles offrent. L’atelier s’est appuyé d’une part sur les Biographies animales de l’historien Éric Baratay (2017), d’autre part sur les œuvres littéraires qui l’ont inspiré et que la classe devait réécrire. Le contenu théorique apporté couvrait des notions de narratologie, d’analyse littéraire, et proposait une approche pluridisciplinaire du concept d’anthropomorphisme. L’analyse des réécritures auxquelles a abouti le cours met en lumière des tendances propres à l’écriture d’un point de vue animal et souligne la difficulté pour les écrivant·es de se libérer des biais anthropomorphiques et anthropocentriques. Les retours étudiants positifs encouragent à proposer davantage ce type d’exercice.
Efficacy against Lung Cancer Is Augmented by Combining Aberrantly N-Glycosylated T Cells with a Chimeric Antigen Receptor Targeting Fragile X Mental Retardation 1 Neighbor
Authors: Toyofuku Toshihiko , Ishikawa Takako , Nojima Satoshi , Kumanogoh Atsushi
Published: January 2024

The adaptive transfer of T cells redirected to cancer cells via chimeric Ag receptors (CARs) has produced clinical benefits for the treatment of hematologic diseases. To extend this approach to solid cancer, we screened CARs targeting surface Ags on human lung cancer cells using (to our knowledge) novel expression cloning based on the Ag receptor-induced transcriptional activation of IL-2. Isolated CARs were directed against fragile X mental retardation 1 neighbor (FMR1NB), a cancer-testis Ag that is expressed by malignant cells and adult testicular germ cells. Anti-FMR1NB CAR human T cells demonstrated target-specific cytotoxicity and successfully controlled tumor growth in mouse xenograft models of lung cancer. Furthermore, to protect CAR T cells from immune-inhibitory molecules, which are present in the tumor microenvironment, we introduced anti-FMR1NB CARs into 2-deoxy-glucose (2DG)–treated human T cells. These cells exhibited reduced binding affinity to immune-inhibitory molecules, and the suppressive effects of these molecules were resisted through blockade of the N-glycosylation of their receptors. Anti-FMR1NB CARs in 2DG-treated human T cells augmented target-specific cytotoxicity in vitro and in vivo. Thus, our findings demonstrated the feasibility of eradicating lung cancer cells using 2DG-treated human T cells, which are able to direct tumor-specific FMR1NB via CARs and survive in the suppressive tumor microenvironment.
Tricuspid valve fungal endocarditis in a patient with breast cancer and an implantable chemotherapy venous access port
Authors: Fountoulakis Petros , Siama Aikaterini , Kalogeris Aimilianos , Iliopoulou Marianthi , Tsoukas Athanasios , Manolis Athanasios
Published: January 2024

Fungal endocarditis, a rare and lethal infection, is etiologically connected with Candida and Aspergillus species. Among these two agents, Candida is a common nosocomial infection with increasing rates over the last years and mortality up to 40% in cases of systemic candidiasis. In the present paper, we describe the case of a 58yearold woman with metastatic breast cancer under palliative chemotherapy who was hospitalized for recurrent episodes of fever due to fungal endocarditis of the implantable venous access port. Such cases may elude the attention of the physician and need to be taken into account especially in oncologic patients with implantable devices under chemotherapy regimens. The treatment of Candida endocarditis can be difficult because of the formation of biofilms on prosthetic devices. The prognosis of these patients may be ameliorated with the combination of fungal and invasive treatment.
Role of Artificial Intelligence in case of Micro Enterprises and Tribal Entrepreneurships for Sustainable Economic Development
Authors: Sahoo Deepali Rani , Teena
Published: January 2024

INTRODUCTION: Tribal entrepreneurship can be understood as infusing the knowledge of commerce and trade into the tribal groups and thereby exploring their products and known for their economic betterment and social advancement. An accumulating body of research has demonstrated that artificial intelligence (AI) is an indistinguishable feature of the fourth industrial revolution. This study integrates the literature on AI and new technologies to examine the constraining and facilitating forces for developing and scaling-up AI-enabling technologies in Africa. This article proposes an integrated conceptual model to elucidate the range of external drivers encompassing global competitive drivers, and market and industry drivers. The internal drivers include the potential to enhance product development speed, improve quality, drive production cost down, and minimise errors and manual processes in organisations. 
OBJECTIVES: In this study, socio-economic status of tribal population has been taken as a reference in order to see whether there is any impact of economic wellbeing on their livelihood [1]. The study is an endeavour to examine the role of micro enterprises for social and economic empowerment of tribal community in Odisha and Andhra Pradesh and role of AI.
RESULTS: The main results obtained in this paper are the following SEM identified that there is a lower degree of positive impact of “Tribal entrepreneurship” on “Economic Empowerment” and “women Empowerment” and lower degree of negative impact on “Social Empowerment”. It is also concluded that Economic Empowerment of tribal entrepreneurs through micro-enterprises has reduced the dependency on private money lenders the most. Women Empowerment of tribal entrepreneurs has helped the women to achieve gender equality and the social Empowerment aids in the development of competency and technical skills through micro-enterprises.
CONCLUSION: The tribal communities in Odisha are regarded as the most disadvantageous group of people in terms of their socio-economic status. The present research makes some pivotal contributions to the current AI literature. First, in spite of the growing recognition that development of new industries and new-business development is increasingly predicated on the adoption of new technologies (Krasniqi and Hajrizi Citation2016), there is a paucity of studies examining contemporary challenges faced by developing nations and their inability to capitalise on such ample and obvious opportunities.
Faltings’ mainp-adic comparison theorems for non-smooth schemes
Authors: He Tongmu
Published: January 2024

To understand thep-adic étale cohomology of a proper smooth variety over ap-adic field, Faltings compared it to the cohomology of his ringed topos, by the so-called Faltings’ mainp-adic comparison theorem, and then deduced various comparisons withp-adic cohomologies originating from differential forms. In this article, we generalize the former to any proper and finitely presented morphism of coherent schemes over an absolute integral closure of$\mathbb {Z}_p$(without any smoothness assumption) for torsion abelian étale sheaves (not necessarily finite locally constant). Our proof relies on our cohomological descent for Faltings’ ringed topos, using a variant of de Jong’s alteration theorem for morphisms of schemes due to Gabber–Illusie–Temkin to reduce to the relative case of proper log-smooth morphisms of log-smooth schemes over a complete discrete valuation ring proved by Abbes–Gros. A by-product of our cohomological descent is a new construction of Faltings’ comparison morphism, which does not use Achinger’s results on$K(\pi ,1)$-schemes.
Clinical study of different prediction models in predicting diabetic nephropathy in patients with type 2 diabetes mellitus
Authors: Cai Sha-Sha , Zheng Teng-Ye , Wang Kang-Yao , Zhu Hui-Ping
Published: January 2024

BACKGROUND

Among older adults, type 2 diabetes mellitus (T2DM) is widely recognized as one of the most prevalent diseases. Diabetic nephropathy (DN) is a frequent complication of DM, mainly characterized by renal microvascular damage. Early detection, aggressive prevention, and cure of DN are key to improving prognosis. Establishing a diagnostic and predictive model for DN is crucial in auxiliary diagnosis.

AIM

To investigate the factors that impact T2DM complicated with DN and utilize this information to develop a predictive model.

METHODS

The clinical data of 210 patients diagnosed with T2DM and admitted to the First People’s Hospital of Wenling between August 2019 and August 2022 were retrospectively analyzed. According to whether the patients had DN, they were divided into the DN group (complicated with DN) and the non-DN group (without DN). Multivariate logistic regression analysis was used to explore factors affecting DN in patients with T2DM. The data were randomly split into a training set (n = 147) and a test set (n = 63) in a 7:3 ratio using a random function. The training set was used to construct the nomogram, decision tree, and random forest models, and the test set was used to evaluate the prediction performance of the model by comparing the sensitivity, specificity, accuracy, recall, precision, and area under the receiver operating characteristic curve.

RESULTS

Among the 210 patients with T2DM, 74 (35.34%) had DN. The validation dataset showed that the accuracies of the nomogram, decision tree, and random forest models in predicting DN in patients with T2DM were 0.746, 0.714, and 0.730, respectively. The sensitivities were 0.710, 0.710, and 0.806, respectively; the specificities were 0.844, 0.875, and 0.844, respectively; the area under the receiver operating characteristic curve (AUC) of the patients were 0.811, 0.735, and 0.850, respectively. The Delong test results revealed that the AUC values of the decision tree model were lower than those of the random forest and nomogram models (P < 0.05), whereas the difference in AUC values of the random forest and column-line graph models was not statistically significant (P > 0.05).

CONCLUSION

Among the three prediction models, random forest performs best and can help identify patients with T2DM at high risk of DN.
Heterogeneously elevated branched-chain/aromatic amino acids among new-onset type-2 diabetes mellitus patients are potentially skewed diabetes predictors
Authors: Wang Min , Ou Yang , Yuan Xiang-Lian , Zhu Xiu-Fang , Niu Ben , Kang Zhuang , Zhang Bing , Ahmed Anwar , Xing Guo-Qiang , Su Heng
Published: January 2024

BACKGROUND

The lack of specific predictors for type-2 diabetes mellitus (T2DM) severely impacts early intervention/prevention efforts. Elevated branched-chain amino acids (BCAAs: Isoleucine, leucine, valine) and aromatic amino acids (AAAs: Tyrosine, tryptophan, phenylalanine)) show high sensitivity and specificity in predicting diabetes in animals and predict T2DM 10-19 years before T2DM onset in clinical studies. However, improvement is needed to support its clinical utility.

AIM

To evaluate the effects of body mass index (BMI) and sex on BCAAs/AAAs in new-onset T2DM individuals with varying body weight.

METHODS

Ninety-seven new-onset T2DM patients (< 12 mo) differing in BMI [normal weight (NW), n = 33, BMI = 22.23 ± 1.60; overweight, n = 42, BMI = 25.9 ± 1.07; obesity (OB), n = 22, BMI = 31.23 ± 2.31] from the First People’s Hospital of Yunnan Province, Kunming, China, were studied. One-way and 2-way ANOVAs were conducted to determine the effects of BMI and sex on BCAAs/AAAs.

RESULTS

Fasting serum AAAs, BCAAs, glutamate, and alanine were greater and high-density lipoprotein (HDL) was lower (P < 0.05, each) in OB-T2DM patients than in NW-T2DM patients, especially in male OB-T2DM patients. Arginine, histidine, leucine, methionine, and lysine were greater in male patients than in female patients. Moreover, histidine, alanine, glutamate, lysine, valine, methionine, leucine, isoleucine, tyrosine, phenylalanine, and tryptophan were significantly correlated with abdominal adiposity, body weight and BMI, whereas isoleucine, leucine and phenylalanine were negatively correlated with HDL.

CONCLUSION

Heterogeneously elevated amino acids, especially BCAAs/AAAs, across new-onset T2DM patients in differing BMI categories revealed a potentially skewed prediction of T2DM development. The higher BCAA/AAA levels in obese T2DM patients would support T2DM prediction in obese individuals, whereas the lower levels of BCAAs/AAAs in NW-T2DM individuals may underestimate T2DM risk in NW individuals. This potentially skewed T2DM prediction should be considered when BCAAs/AAAs are to be used as the T2DM predictor.
Body composition and metabolic syndrome in patients with type 1 diabetes
Authors: Zeng Qiong , Chen Xiao-Jing , He Yi-Ting , Ma Ze-Ming , Wu Yi-Xi , Lin Kun
Published: January 2024

BACKGROUND

In recent years, the prevalence of obesity and metabolic syndrome in type 1 diabetes (T1DM) patients has gradually increased. Insulin resistance in T1DM deserves attention. It is necessary to clarify the relationship between body composition, metabolic syndrome and insulin resistance in T1DM to guide clinical treatment and intervention.

AIM

To assess body composition (BC) in T1DM patients and evaluate the relationship between BC, metabolic syndrome (MS), and insulin resistance in these indi-viduals.

METHODS

A total of 101 subjects with T1DM, aged 10 years or older, and with a disease duration of over 1 year were included. Bioelectrical impedance analysis using the Tsinghua-Tongfang BC Analyzer BCA-1B was employed to measure various BC parameters. Clinical and laboratory data were collected, and insulin resistance was calculated using the estimated glucose disposal rate (eGDR).

RESULTS

MS was diagnosed in 16/101 patients (15.84%), overweight in 16/101 patients (15.84%), obesity in 4/101 (3.96%), hypertension in 34/101 (33.66%%) and dyslipidemia in 16/101 patients (15.84%). Visceral fat index (VFI) and trunk fat mass were significantly and negatively correlated with eGDR (both P < 0.001). Female patients exhibited higher body fat percentage and visceral fat ratio compared to male patients. Binary logistic regression analysis revealed that significant factors for MS included eGDR [P = 0.017, odds ratio (OR) = 0.109], VFI (P = 0.030, OR = 3.529), and a family history of diabetes (P = 0.004, OR = 0.228). Significant factors for hypertension included eGDR (P < 0.001, OR = 0.488) and skeletal muscle mass (P = 0.003, OR = 1.111). Significant factors for dyslipidemia included trunk fat mass (P = 0.033, OR = 1.202) and eGDR (P = 0.037, OR = 0.708).

CONCLUSION

Visceral fat was found to be a superior predictor of MS compared to conventional measures such as body mass index and waist-to-hip ratio in Chinese individuals with T1DM. BC analysis, specifically identifying visceral fat (trunk fat), may play an important role in identifying the increased risk of MS in non-obese patients with T1DM.
PEMODELAN GEOGRAPHICALLY WEIGHTED REGRESSION TERHADAP FAKTOR-FAKTOR YANG MEMPENGARUHI ANGKA PUTUS SEKOLAH MENENGAH KEJURUAN DI PROVINSI SUMATERA UTARA
Authors: Dur Sajaratud , Cipta Hendra , Rizki Nurul Aprilla
Published: January 2024

The proportion of kids who are of school age but are no longer enrolled or did not complete their education at a certain level is known as the dropout rate. The majority of dropouts are from vocational high schools. One of the reasons why students leave school is because the causes of dropouts are not accurately identified. This issue persists in the field of education. One issue with geographic heterogeneity is dropout. the development of geographical effects or spatial heterogeneity as a result of variations in each region's features and the connection between their distances. Geographically Weighted Regression (GWR) is one technique for analyzing spatially heterogeneous issues. The fixed kernel's weighting function and the adaptive kernel's weighting function in this research are both gaussian. The goal of this research was to choose the most appropriate model to utilize for the GWR model on the variables influencing the dropout rate for vocational high schools in North Sumatra Province. For each North Sumatra district or city, a distinct model is generated by this study. As compared to the multiple linear regression model with Ordinary Least Square (OLS) and the GWR model with fixed kernel weighting function gaussian, the GWR model with the adaptive weighting function of the gaussian kernel is the best model used to model the factors that influence the dropout rate for vocational high schools in North Sumatra Province. This is because it has the smallest AIC value of 321.7397 and the highest of 0.9756.