bluuebunny/crossref_metadata_2025 huggingface dataset:
The role of gaseous mediators (CO, NO and H2S) in the regulation of blood circulation: analysis of the participation of blood cell microrheology
Authors: Muravyov A. V.
Published: March 2021

Among the signaling molecules involved in the regulation of intra- and intercellular systems in various types of cells, a special place is occupied by gaseous compounds – gasotransmitters (GTs). Currently, the most studied are three molecules: nitrogen oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S). For them, the enzymatic systems of intracellular synthesis and degradation have been determined, the physiological effect has been proved, and the intracellular mechanisms have been determined. Changes in the work of these mechanisms under the influence of GTs causes the development of physiological and/or pathophysiological reactions. These GTs are involved in the regulation of various organs and systems of the human body under normal and pathological conditions, including the structure and function of the circulatory system. In this article, special attention is paid to the influence of all three GTs and their donors on the vascular and hemorheological aspect of the work of blood circulation, and especially on an underdeveloped problem – the microrheology of erythrocytes. It has been shown that all three GTs, along with the well-known vasodilating effect, reduce the adhesion and aggregation of platelets and leukocytes, as well as moderately stimulate the deformability of erythrocytes and strongly inhibit their aggregation. The performed analysis of the data indicates that, along with the specific signaling cascades for each GT, the use of a common signaling pathway associated with soluble guanylate cyclase and NO synthase was also revealed in microrheological responses. The intersection of signaling pathways triggered by NO, CO and H2S on common effectors, as well as their interaction with each other (cross-talk), can determine the final, resulting functional response of the cell.
Assessment Of Tumour Infiltrating Lymphocytes And Pd-l1 Expression In Adenoid Cystic Carcinoma Of The Salivary Gland
Authors: Chen Wenqian , Fung Andrea S. , McIntyre John B. , Simpson Roderick , Afzal Arfan R. , Hao Desiree , Lau Harold
Published: March 2021

Purpose: Early phase clinical studies are ongoing to evaluate the role of immune checkpoint inhibitors in adenoid cystic carcinoma (ACC) despite a paucity of information on the immune microenvironment. This study aims to better characterize the immune microenvironment of ACC tumours and evaluate survival outcomes based on tumour infiltrating lymphocyte (TIL) and programmed death-ligand 1 (PD-L1) expression.

Methods: Patient characteristics, treatment and outcome data were collected for 24 ACC patients. The CD8+(cluster of differentiation 8) TIL and PD-L1 expression were quantified by immunohistochemistry. Marker expression and survival outcomes were evaluated by Kaplan-Meier analysis.

Results: All cases were negative for PD-L1 expression; four cases had focal high, eight cases had focal moderate and 12 cases had low TIL expression. Based on TIL expression, there was no difference in disease-free or overall survival.

Conclusion: Adenoid cystic carcinoma tumours were found to be associated with a poor immunogenic microenvironment, with absent PD-L1 expression and low CD8+ TILs. There was no association between TIL expression and survival. These data suggest that PD-L1 and TIL expression are unlikely to be useful as predictive biomarkers for response to immunotherapy.
СИНТЕЗ РЕГУЛЯТОРА КОНТУРУ КУТА КРЕНУ СИСТЕМИ УПРАВЛІННЯ КВАДРОКОПТЕРА З КОМПЕНСУЮЧИМ РЕГУЛЯТОРОМ КОНТУРУ СТРУМУ
Authors: Denisov Yurii , Gorodny Oleksiy , Sereda Oleg
Published: March 2021

Актуальність теми дослідження. Постановка теми дослідження викликана необхідністю підвищення якості енергетики та динаміки в системах управління польотом безпілотних літальних апаратів (БПЛА), враховуючи їх зростаючу роль у промисловій, побутовій та військовій сферах.
Постановка проблеми. У системах керування польотом БПЛА з чотирма несучими гвинтами (квадрокоптер) процеси керування впливають на процеси споживання електроенергії від бортового акумулятора. Втрати потужності в силових компонентах систем керування квадрокоптером можна знизити, якщо усунути вплив пульсацій проти-е.р.с. електродвигуна на форму струму, що споживається від акумулятора. Досягнення цієї мети можливе за рахунок реалізації необхідних законів керування в контурах системи. Аналіз останніх досліджень і публікацій. Аналіз відомих публікацій за темою дослідження показав, що в них не приділено уваги питанням економного використання енергетичного ресурсу акумулятора. Основна увага приділяється удосконаленню процесів управління та навігації без урахування їх зв’язків з енергетичними процесами. Виділення недосліджених частин загальної проблеми. Існування поставленої проблеми є наслідком неврахування впливу процесів управління на якість процесів енергоспоживання. Це проявляється в тому, що в наявних одноконтурних системах керування квадрокоптером регулятор настроюється на необхідну швидкодію та перерегулювання без урахування впливу закону керування на якість енергетичних процесів, тобто без контролю форми струму, що споживається. Постановка завдання. Відомі системи керування квадрокоптером мають один контур регулювання. Для контролю струму, що споживається від акумулятора, необхідно мати контур струму та контур швидкості, що підкорюється головному контуру кута крену. Система керування польотом БПЛА повинна мати три контури регулювання. Виклад основного матеріалу. Для триконтурної системи керування польотом квадрокоптера виконано синтез
цифрового регулятора головного контуру, котрий регулює кут крену. Процедура синтезу включає в себе врахування впливу пропорційно-інтегрального регулятора з астатизмом другого порядку, який включений у контур струму для компенсації пульсацій проти-е.р.с. безколекторного двигуна постійного струму (БДПС). У результаті синтезу отримана структура і параметри ланок регулятора контуру кута крену у вигляді цифрового рекурсивного фільтра. Висновки відносно статті. Синтезовано цифровий регулятор контуру кута крену для триконтурної системи управління квадрокоптером. Регулятор дозволяє стабілізувати процес польоту з економією енергетичного ресурсу бортового акумулятора.
ТЕХНОЛОГІЯ ВИГОТОВЛЕННЯ ЖИТНЬО-ПШЕНИЧНОГО ХЛІБА НА ЗАКВАСКАХ ІЗ ВИКОРИСТАННЯМ БАЗИЛІКУ
Authors: Savchenko Olesya , Kalinichenko Yuliia
Published: March 2021

Актуальність теми дослідження. Хлібопекарські підприємства активно розвиваються в напрямку застосування прискорених технологій виробництва житньо-пшеничного хліба на заквасках.
Постановка проблеми. Поширення ресурсозберігаючих прискорених технологій зумовлюють зниження якості хлібобулочних виробів, приводять до необхідності використання поліпшувачів і консервантів, часто синтетичного походження. Актуальним є пошук способів підвищення якості хлібобулочних виробів шляхом удосконалення технологій виробництва за рахунок використання природної сировини.
Аналіз останніх досліджень і публікацій. У наукових публікаціях показана перспективність використання добавок природного походження, обґрунтовано доцільність використання їх для підвищення харчової цінності та поліпшення технологічних показників хліба. Виділення недосліджених частин загальної проблеми. Особливої уваги для вирішення зазначеної проблеми прискорення технологічного процесу та підвищення харчової цінності хлібобулочних виробів слід надати рослинній сировині з високим вмістом біологічно активних речовин. Одним із перспективних напрямів наукових досліджень є додавання пряно-ароматичної сировини, зокрема базиліку. Аналіз показав, що нині базилік застосовують більше як пряності, а не поліпшувача технологічного процесу приготування житньо-пшеничного хліба на заквасках спонтанного бродіння. Постановка завдання. Розробка технології виробництва житньо-пшеничного хліба на заквасках спонтанного бродіння з використанням базиліку як поліпшувача природного походження. Виклад основного матеріалу. Розроблена рецептура приготування житньо-пшеничного хліба на заквасці спонтанного бродіння з додаванням базиліку в кількості від 0,5 до 1,5 % до маси борошна. Дослідженнями встановлено,
що базилік покращує структурно-механічні властивості тіста зі слабкою клейковиною. Високий вміст біологічно активних речовин базиліку активує бродильну активність молочнокислих бактерій і покращує органолептичні та фізико-хімічні властивості хліба. Висновки відповідно до статті. Показано доцільність використання базиліку для скорочення тривалості технологічного процесу приготування житньо-пшеничного хліба. Отримані зразки житньо-пшеничного хліба з додаванням досліджуваної добавки мають приємні органолептичні властивості, пористу м’якушку, привабливий колір із
золотистою скоринкою. Добавка збагачує вироби вітамінами, макро- і мікроелементами, не викликає зниження споживчих та технологічних властивостей хліба.
ЗБЕРІГАННЯ ПЛОДІВ АБРИКОСА З ВИКОРИСТАННЯМ ЛІКАРСЬКО-РОСЛИННИХ ЕКСТРАКТІВ
Authors: Dubinina Antonina , Letuta Tatiana , Novikova Vira
Published: March 2021

Актуальність теми дослідження. Абрикос характеризується високою інтенсивністю дихання та метаболізму, й найбільшою чутливістю до етилену серед усіх кісточкових плодів – це зумовлює надзвичайно короткий термін зберігання плоду. Раніше недостатньо уваги приділяли подовженню терміну зберігання абрикоса як окремого плоду, тому найчастіше для його зберігання використовували відомі технології: швидке заморожування, регульовану атмосферу та зберігання у спеціальній тарі. Постановка проблеми. Однак такі технології не передбачають запобігання утворенню або розповсюдженню основних грибкових інфекцій абрикоса. Аналіз останніх досліджень та публікацій. Багаторазове застосування деяких системних фунгіцидів у аграрних господарствах призвело до появи фунгіцид-стійких патогенів. Деякі фунгіциди, особливо фталімідні, спричиняють хімічні травми епідермісу абрикосів. Оскільки використання фунгіцидів під час заготівлі абрикосів є необхідним, але потенційно шкідливим, у країнах Європи вже давно були ініційовані дослідження з розробки природних, ефективних і нетоксичних для плодів абрикоса й споживача фунгіцидних засобів. Уже багато років пріоритетними технологіями зберігання плодів абрикоса є швидке заморожування, регульована атмосфера, зберігання у спеціальній тарі. Однак сучасні технології зберігання не передбачають знищення або пригнічення грибкових інфекцій плодів. Постановка завдання. Метою статті є аналіз літературних джерел щодо існуючих технологій зберігання абрикоса та використання лікарсько-технічної сировини як компонента, що пригнічує основні грибкові інфекції, для подовження зберігання фрукта у свіжому вигляді. Виклад основного матеріалу. Для подовження терміну зберігання нами запропоновано використовувати захисний засіб з антибактеріальними властивостями проти основних грибкових інфекцій абрикоса – грибків роду Monilinia (Monilinia laxa, Monilinia fructicola) та Rhizopus stolonifer. Оскільки важливою характеристикою безпечності речовин, що контактують безпосередньо з продуктами харчування, є мінімальна токсичність і високі антибактерицидні властивості, для застосування в розробці нової технології рекомендовані водні та водно-спиртогліцеринові екстракти рослинної сировини – листя меліси та шавлії, трава вербени. Висновки відповідно до статті. На основі аналізу сучасної вітчизняної та зарубіжної літератури робимо висновок, що засіб із використанням таких екстрактів може стати новим ефективним антибактерицидним препаратом для зберігання плодів абрикоса у свіжому вигляді.
MODIFIED POLYSACCHARIDES APPLICATION FOR ANTISEPTIC LEATHER PROCESSING
Authors: Plavan Viktoriia , Ishchenko Olena , Resnytskyi Ilya , Liashok Iryna , Kuchynska Daria
Published: March 2021

Urgency of the research. The leather is very sensitive to microbial degradation during processing, storage, transportation and use. Therefore, it is important to search for preparations and methods of leather treatment, providing specific fungicidal
properties, depending on the purpose. Target setting. To establish the possibility of using a composition based on modified polysaccharides with the addition of PVA and Quaternary ammonium salts for leather treatment to give fungicidal properties.
Actual scientific researches and issues analysis. Recent open access publications have been reviewed regarding polymeric materials, antiseptic and fungicidal preparations used to obtain of insole leather with special properties. Uninvestigated parts of general matters defining. The principle of action of many fungicidal or bactericidal products
when used together has not been established. In particular, in the case of the simultaneous use of modified polysaccharides and quaternary ammonium salts for antiseptic treatment of the leather. The research objective. The purpose of the work is to research antiseptic properties of the coating based on modified polysaccharides with the addition of quaternary ammonium salts (QASc) for insole leather. The statement of basic materials. It is established that the polymer composition based on modified starch and polyvinyl alcohol with the addition of a quarter of ammonium salts gives the leather antiseptic properties, this is proved by the delay of growth of microorganisms by 3-4 mm from the edge of the sample. The relative air permeability of the leather is reduced by almost half (from 1.18 · 103 to 0.54 · 103 cm3 / cm2 • h), the leather porosity is also reduced by 5-10 % and the stiffness is increased by 40 %. Conclusions. As a result of the conducted researches it is established that although treatment of leather surface by a
solution CMS: PVA and QASс reduction of the tensile strength of leather but in its physical and mechanical properties the treated leather meets the requirements for the lining, has antiseptic properties and can be used for the manufacture of insoles.
As serpentes vindas do Médio Oriente nos Textos das Pirâmides. Reflexão sobre as relações egípcias-orientais nos textos religiosos mais antigos
Authors:   University of Warsaw (Polonia), Popielska-Grzybowska Joanna
Published: March 2021

The Pyramid Texts created in Ancient Egypt and contextualised by the belief in life beyond death, were intended to accompany the deceased in their journey to the Hereafter, to protect and ensure the realisation of their needs there. The oldest religious texts demonstrate positive aspects, delight and lust for life and, due to the fact that they were composed in order to assist the pharaoh on his way to the sky and the true existence of the king in the Beyond, could never be questioned or endangered. However, despite everything evoked here, there are attestations of inimical forces, or perils, which are to be fought off. Emphasis will be placed on the question of how the “serpent spells” and use of language in them manifest the relationship of the pharaoh and the Egyptians with the inhabitants of the Near East. The ideas of the presumed origin of the formulae and the link with the creator Atum in the texts under discussion is also presented. One can trace the quiddity of the world as a complete work of the ancient Egyptian creator. Therefore, the author of the paper aims to scrutinise, with reference to contextual arguments, the language of the diagnostic “serpent spells” of the Pyramid Texts, namely the grammar, choice of vocabulary, phraseology, possible onomatopoeic effects, to elucidate linguistic means of expression used in the Pyramid Texts. The methodology of the linguistic worldview is used.
Choosing the Location of a ‘House for Eternity’. A Survey on the Relationship between the Rank of the Hatshepsut’s Officials and the Location of their Burials in the Theban Necropolis
Authors:   University of Liverpool (Reino Unido), Candelas Fisac Juan
Published: March 2021

This survey aims to determine if a link exists between features of the Theban landscape and where the Egyptian elite chose to build their houses of eternity within the context of the early Eighteenth Dynasty. It is hoped that through GIS-generated tomb location maps, the analysis of their owners’ status and reflection on the landscape’s topography, this study will be able to approximate a relationship between the ranking of Hatshepsut’s officials and the location of their tombs in the necropolis of Western Thebes. This is driven by the current limits in our understanding of the inner hierarchy among officials as well as the tomb site selection process and, therefore, the necessity of expanding such limits.
Más allá de la narrativa: aportes para una aproximación integral a la Segunda Estela de Kamose
Authors:   Pontificia Universidad Católica (Argentina), Flammini Roxana
Published: March 2021

The aim of this contribution is to highlight the traces of diverse social practices on the Second Stela of Kamose, whose relevance is not usually recognized. The stone on which the Stela was engraved has a long history. It comes from a Middle Kingdom door jamb probably belonging to a royal building erected at the temple. After several centuries of being located in the temple, the Stela was buried into the base of a statue of Ramesses II, where it was found in 1954, in front of the Second Pylon. Not only is the reuse of monuments highlighted here, but also other practices made on the monument’s surface: the damnatio memoriae and the scribble of graffiti. Thus, the Stela becomes an appropriate example to observe, analyze and reflect on those social practices, which in turn make it a relevant monument by itself, beyond the content of the well-known written text
El acto sexual como agente del (re)nacimiento de Osiris
Authors:   Universitat Autònoma de Barcelona (España), Orriols-Llonch Marc
Published: March 2021

One of the most important myths of the Ancient Egypt civilization is Osiris’ cyclical myth. Even though not enough attention has been given to it, one of the most important mythemes is the sexual act between the god and Isis. This sexual act establishes two pillars of the monarchy in Ancient Egypt: the conception and the subsequent birth of Horus (the archetype of the earthly Egyptian king) and Osiris’ (re)birth (king of the Underworld and archetype of the dead). Regardless of the great importance of this sexual act, the sources that relate to it are scarce. On a textual level, the intercourse between both divinities has been documented since the Pyramid Texts until the end of the Pharaonic Period. However, it appears narrated on very few occasions with verbs carrying explicit sexual meaning. Only the context allows one to see that the protagonists are having sexual relations. Since Osiris is dead, Isis is the obvious agent of the action, an exception that makes the goddess different from the rest of her peers. Regarding iconography, only three images have been documented in the Dynastic Period: one in the Middle Kingdom and two in the New Kingdom. In all of them the image is the same, the anthropomorphic Osiris, lies in his funerary bed while Isis, in the shape of a bird of prey, copulates with him.
Numerical Study of the Dynamics of Gold Heating by Ultra-Short Dichromatic Laser Pulses
Authors: Zhukov Vladimir P. , Bulgakov Alexander V. , Bulgakova Nadezhda M.
Published: March 2021

The interaction of femtosecond laser pulses of moderate intensity with metals by the example of gold is studied. The main attention is paid to dichromatic regimes of laser irradiation corresponding to a new trend in the field of laser pro-cessing of materials. Based on the two-temperature approximation, a new model is created which involves a dichro-matic source of the laser radiation energy and also takes into account the influence of the electron temperature on the reflection coefficient of the irradiated material and thermophysical properties of its electronic subsystem. For numerical implementation of the model, an implicit divergent finite-difference scheme is created with an improved method for describing the melting process in comparison with previous works. The model calculations have shown that the absorption of the laser energy by gold depends on the sequence of two pulses at different wavelengths and the delay time between them, and for correct description of the absorbed energy, it is necessary to take into account the change of the reflection coefficient of the surface during irradiation. The developed model may be of interest for optimizing the processing of materials with ultra-short dichromatic laser pulses.
Vulnerabilidade e as violências mais comuns enfrentadas pelas mulheres brasileiras
Authors: Tinoco Nayandra da Silva , Dos Santos Adriene Roberta Costa , Fialho Salinny da Silva Ferreira , Redman Raquel De Souza , Lima Alaine Naielly da Silva , Dos Santos Janeide de Souza , Rocha Suellen Karine da Silva , Costa Cheila Aparecida Almenares , Serrão Dablina Jasmine Farias Colares , Figueiredo Silvana Nunes
Published: March 2021

Objetivo: Identificar quais são as vulnerabilidades das mulheres brasileiras e sua relação com os tipos mais comuns de violência.  Métodos: Trata-se de um estudo descritivo exploratório onde optou-se por métodos de Revisão Integrativa de Literatura (RIL). A busca por publicações cientificas foi realizada de abril de 2019 a outubro de 2020, utilizando-se bibliotecas virtuais: Biblioteca Virtual em Saúde (BVS), LILACS e Scientific Electronic Library Online (SCIELO). Resultados: A maior parte dos artigos utilizados é de 2018, a faixa etária manteve-se diversificada e a maioria das mulheres eram pretas ou pardas, casadas e com baixo nível de escolaridade, os tipos de violência mais comuns foram a violência psicológica seguida da física, o principal agressor costuma ser o parceiro íntimo e o local de ocorrência da violência costuma ser a residência da vítima. Considerações finais: Portanto, é observado que quando as mulheres são pretas ou pardas e com baixo nível escolar as chances de serem vítimas aumenta, o que mostra a necessidade de se conhecer o perfil da mulher que sofre violência.
Tubular laminectomy and percutaneous vertebroplasty for aggressive vertebral hemangioma
Authors: Papadakos Dimitrios , Boulieris Spiros , Theofanopoulos Andreas , Fermeli Dionysia , Constantoyannis Constantine
Published: March 2021

Background:

Vertebral hemangiomas (VH) are the most common benign vascular neoplasms of the spine. Aggressive VH (AVH) may become symptomatic due to soft-tissue expansion/extraosseous extension into the paraspinal and/or epidural spaces. There are several options for treating painful AVH, including radiotherapy and/or open surgery.

Case Description:

A 59-year-old male presented with a 2-year history of intermittent back pain and progressive thoracic myelopathy in the past 2 months. MRI revealed a T9 level lesion, with high-intensity signal on both T1 and T2 images and an extraosseous component with significant cord compression. We performed minimally invasive tubular unilateral laminotomy for bilateral decompression of the thoracic spine at the T9 level, followed by bilateral percutaneous vertebroplasty with biopsy. Postoperatively, the pain was immediately relieved, and the myelopathy improved. The biopsy confirmed the diagnosis of a VH.

Conclusion:

Combining minimally invasive techniques consisting of tubular laminectomy and percutaneous vertebroplasty are safe and effective ways for treating AVHs.
Communication Analysis of Rubber Farmers in Riau Province, Indonesia
Authors: Roza Yulida  , Rosnita  , Andriani Yulia , Ikhwan Muhammad
Published: March 2021

Communication is an essential part of the process of development. Therefore, effective communication is needed to achieve development goals. Rubber is the second largest commodity in Riau Province, after oil palm, and most of rubber commodities are managed by independent rubber farmers. Successful development of rubber farming is needed in order to increase the income and welfare of rubber farmers. However, effective communication is needed to achieve these objectives. The objectives of this study are to; (1) describe the internal and external characteristics of rubber farmers; (2) analyze the relationship between the characteristics and the effectiveness of the communication by rubber farmers. Research was conducted in two potential rubber commodity districts in Riau Province, e.g Kuantan Singingi Regency and Kampar Regency. Respondents in this study were determined by objective sampling and random sampling methods, with 143 rubber farmers as respondents. The results showed (1) the internal characteristics and external characteristics of the rubber farmers in an adequately supportive category; (2) the internal characteristics (education, number of dependents, land area and cosmopolitan area) and the external characteristics (intensity of enhancement, accuracy of extension channels and number of sources of information) have a significant correlation with the efficacy are significant correlated with the effectiveness of group and interpersonal communication. In order for effective communication in farmer group institutions (group communication), it is necessary to increase the intensity of extension, appropriate media extension and increase the number of information sources that are easily accessible by rubber farmers.
Evaluation of Input/Output Interface using Wrinkles on Clothes
Authors: Ueda Kentaro , Terada Tsutomu , Tsukamoto Masahiko
Published: March 2021

Wearable computing has created textile-based interfaces utilizing the interaction between the user and cloth for operation, as well as the touch and the pinch input operation. The user wears and uses the device in various postures, environments, and operating positions that affect the operation speed and accuracy. However, no study has assessed such factors of touching and pinching using the same input interface. One of the textile interfaces has an input interface using wrinkles on clothes. A ridge of cloth produces a wrinkle that forms naturally on clothes, and the shape of these wrinkles can be recognized by their tactile sensations. Additionally, the act touching or pinching wrinkles does not look strange to an onlooker, which reach that wrinkles have the potential suitable for the wearable computing operation. To reveal the potential, this paper evaluates the input performance using wrinkles on clothes. We designed three touch input methods and one pinch input method for the operation using wrinkles. We implemented the input and the output device which use wrinkles and carried out four evaluations. The results indicated that the pinch input reached the highest accuracy of 98\% of four input methods after learning. The narrowing-down selection reached the fastest input time of 1.64 seconds of four methods after learning. The long press touch and the pinch input achieved the accuracy of 90\% or more in all combination of operating environments and device positions. According to the result of the wrinkle recognition, users have a high accuracy of the identification of wrinkles of 89.4\% and recognize their shape in approximately 12 seconds.
Fast Affinity Propagation by Cell-based Indexing
Authors: Shiokawa Hiroaki , Matsushita Tomohiro , Kitagawa Hiroyuki
Published: March 2021

Affinity Propagation is one of the fundamental clustering algorithms used in various Web-based systems and applications. Although Affinity Propagation finds highly accurate clusters, it is computationally expensive to apply Affinity Propagation to a large dataset since it requires iterative computations for all possible pairs of data objects in the dataset. To address the aforementioned issue, this paper presents efficient Affinity Propagation algorithms, namely \textit{C-AP}. In order to increase the clustering speed, C-AP employs \textit{cell-based index} to reduce the number of the computed data object pairs in the clustering procedure. By using the cell-based index, C-AP efficiently detects unnecessary pairs, which do not contribute to its clustering result. For further reducing the computation time, we also present an extension of our algorithm named \textit{Parallel C-AP} that utilizes thread-parallelization techniques. As a result, C-AP and Parallel C-AP detects the same clusters as those of Affinity Propagation with much shorter computation time. Extensive evaluations demonstrate the performance superiority of our proposed algorithms over the state-of-the-art algorithms.
An Efficient System for Supporting Bat Swing of Beginners in Baseball Using Wearable Sensors
Authors: Ito Hiroaki , Gotoh Yusuke
Published: March 2021

Recently a support system that improves sports skills using sensor or video camera data is attracting great attention. Since most of these systems are developed for professional athletes, few are available for beginners. In baseball, since hitting skills are generally acquired based on oral pantomimed by baseball experts, it is difficult for beginners to understand the advice based on the skill level of baseball experts. In this paper, we propose a support system through which beginners improve their hitting skills by analyzing the batting stance of baseball players using such wearable sensors as acceleration and angular velocity sensors. In our proposed system, beginners swing based on wearable sensors that compose a triaxial acceleration sensor and an angular velocity sensor to the bat and the body. Next, experts in baseball can analyze the modification of the batting stance of beginners by measuring the sensor values of the swing. In the evaluation result, our proposed system analyzed the differences of batting stance between experts and beginners in baseball and confirmed that we can effectively support the hitting skill of baseball beginners.
Independent Game Developers and Their Expectations Towards Recommender Systems
Authors: Kholodylo Marta , Strauss Christine
Published: March 2021

Electronic recommender systems and digital distribution as such have transformed many industries. Digital games is one of those industries where the transformation is particularly evident, as more and more games are appearing on the market, and most of the titles are published by independent game developers. Due to electronic recommender systems developers can now self-publish their content without the mediation of third parties and additional costs for their services. This change has significantly decreased the costs of game production, distribution, and marketing, allowing more studios to engage in releasing their games on their own. However, it is unclear how the developers themselves perceive the effect of electronic recommender systems of their business models. This paper presents a qualitative study on the impact of electronic recommender systems in context of independent game development. Based on semi-structured expert interviews with active game developers who have been engaged in promoting their games through electronic recommender systems, our study provides insights on how independent game developers perceive those systems as part of their value chain and their business model. The results of the study concern to (i) independent game developers to establish, adapt, review, or improve their business model, and (ii) providers and developers of electronic recommender systems as indication of needs and requirements as well as expectations of their potential content creators.
Knowledge Graph Completion to Solve University Campus Issues
Authors: Tsukagoshi Yuto , Kawamura Takahiro , Sei Yuichi , Tahara Yasuyuki , Ohsuga Akihiko
Published: March 2021

A number of urban challenges are encountered by modern societies. Governments, businesses and public bodies need to make statistical data widely available in order to tackle these challenges. Nonetheless, current literature and data are problematic; they have inaccuracies which lead to less effective methods of resolving these issues. This research aims to solve this challenge by thinking of a university campus as a microcosm of society, implementing a data integration schema, and combining data into a knowledge graph. Existing completion methods will then be applied and updated. Especially in regards to bicycle environment, our knowledge graph was tailored and evaluated in line with conventional methods, and secondly with our proposed derivative methods. Roughly 650 pieces of parking data, with various dates and times, was contrasted with each time's mean absolute error. Our approach accurately projected 54.5 more bicycles than the conventional method.
Characterization of Fake News Based on Subjectivity Lexicons
Authors: Jeronimo Caio L.M. , Marinho Leandro B. , Carmpelo Cclaudio E.C. , Veloso Adriano , Da Costa Melo Allan S.
Published: March 2021

While many works investigate spread patterns of fake news in social networks, we focus on the textual content. Instead of relying on syntactic representations of documents (aka Bag of Words) as many works do, we seek more robust representations that may better differentiate fake from legitimate news. We propose to consider the subjectivity of news under the assumption that the subjectivity levels of legitimate and fake news are significantly different. For computing the subjectivity level of news, we rely on a set subjectivity lexicons for both Brazilian Portuguese and English languages. We then build subjectivity feature vectors for each news article by calculating the Word Mover's Distance (WMD) between the news and these lexicons considering the embedding the news words lie in, in order to analyze and classify the documents. The results demonstrate that our method is robust, especially in scenarios where training and test domains are different.
Clause-level Analysis High-value Reviews based on Sentiment
Authors: Nadamoto Akiyo , Akiyama Kazuhiro , Kumamoto Tadahiko
Published: March 2021

Today, huge numbers of reviews are posted on the internet. Online shoppers often refer to reviews written about the products. A review has a star rating that represents what other people think about the product. However, the star rating is not always appropriate for evaluating the product. High-value reviews that affect the users' willingness to buy are independent of the number of stars in ratings. High-value reviews are those from which people find useful information those regarded as good reviews. As described in this paper, we investigated the relation between high-value reviews and the sentiment (positive/negative/neutral) of their clauses based on four hypotheses. We extract characteristics of high-value reviews based on our results. Furthermore, we propose a classification method that classifies clause level sentiment from reviews.
owards a quantum-inspired proof for IP = PSPACE
Authors: Green Ayal , Kindler Guy , Liu Yupan
Published: March 2021

We explore quantum-inspired interactive proof systems where the prover is limited. Namely, we improve on a result by \cite{AG17} showing a quantum-inspired interactive protocol ($\IP$) for $PreciseBQP$ where the prover is only assumed to be a $\PreciseBQP$ machine, and show that the result can be strengthened to show an $\IP$ for $\NP^{\PP}$ with a prover which is only assumed to be an $\NP^{\PP}$ machine - which was not known before. We also show how the protocol can be used to directly verify $\QMA$ computations, thus connecting the sum-check protocol by \cite{AAV13} with the result of \cite{AG17,LFKN90}. Our results shed light on a quantum-inspired proof for $\IP=\PSPACE$, as $\PreciseQMA$ captures the full $\PSPACE$ power.
An HHL-based algorithm for computing hitting probabilities of quantum walks
Authors: Guan Ji , Wang Qisheng , Ying Mingsheng
Published: March 2021

We present a novel application of the HHL (Harrow-Hassidim-Lloyd) algorithm --- a quantum algorithm solving systems of linear equations --- in solving an open problem about quantum walks, namely computing hitting (or absorption) probabilities of a general (not only Hadamard) one-dimensional quantum walks with two absorbing boundaries. This is achieved by a simple observation that the problem of computing hitting probabilities of quantum walks can be reduced to inverting a matrix. Then a quantum algorithm with the HHL algorithm as a subroutine is developed for solving the problem, which is faster than the known classical algorithms by numerical experiments.
Predicting Low Toxicity and Scalable Solvent Systems for High Speed Roll-to-Roll Perovskite Manufacturing
Authors: Swartwout Richard , Patidar Rahul , Belliveau Emma , Dou Benjia , Beynon David , Greenwood Peter , Moody Nicole , deQuilettes Dane W. , Bawendi Moungi , Watson Trystan M. , Bulovic Vladimir
Published: March 2021

This manuscript introduces solvent toxicity in solar perovskite ink chemistries as a major technoeconomic limitation for the growth of the technology. More specifically, the capital and operational cost of handling such toxic chemicals to maintain a safe working environment can lead to significant added costs. As all record power conversion efficiency devices to date have been solution processed, this represents a major challenge for the perovskite optoelectronic field and of printed electronics as a whole. Knowing this limitation, we propose that solvent selections for ink chemistries should be more quantitative and focus on lowering toxicity. To this end, we show that a Hansen solubility model is effective in predicting ink systems using lower toxicity solvents. We also show that inks formed from this method are applicable for high-speed slot-die coating, limiting the need for long anneal times. These methods and results demonstrate a useful framework for quantitatively engineering solvent systems with reduced toxicity while simultaneously maintaining and surpassing performance. It therefore provides a pathway and major step forward towards the commercialization of solution coated perovskite technologies.
Identifying conformational isomers of organic molecules in solution via unsupervised clustering
Authors: Marinova Veselina , Dodd Laurence , Lee Song-Jun , P. F. Wood Geoffrey , Marziano Ivan , Salvalaglio Matteo
Published: March 2021

We present a systematic approach for the identification of statistically relevant conformational macrostates of organic molecules from molecular dynamics trajectories. The approach applies to molecules characterised by an arbitrary number of torsional degrees of freedom and enables the transferability of the macrostates definition across different environments. We formulate a dissimilarity measure between molecular configurations that incorporates information on the characteristic energetic cost associated with transitions along all relevant torsional degrees of freedom. Such metric is employed to perform unsupervised clustering of molecular configurations based on the fast search and find of density peaks algorithm. We apply this method to investigate the equilibrium conformational ensemble of Sildenafil, a conformationally complex pharmaceutical compound, in different environments including the crystal bulk, the gas phase and three different solvents (acetonitrile, 1-butanol, and toluene). We demonstrate that, while Sildenafil can adopt more than one hundred metastable conformational configurations, only 12 are significantly populated across all the environments investigated. Despite the complexity of the conformational space, we find that the most abundant conformers in solution are the closest to the conformers found in the most common Sildenafil crystal phase.
Metal-Free Four-Step Domino Reaction Enables Fully Controlled Non-Statistical Synthesis of Hexaarylbenzene with Six Different Aryl Groups
Authors: Grau Benedikt , Dill Maximilian , Hampel Frank , Kahnt Axel , Jux Norbert , Tsogoeva Svetlana B.
Published: March 2021

Hexaarylbenzene (HAB) derivatives are versatile aromatic systems playing a significant role as chromophores, liquid crystalline materials, molecular receptors, redox materials, organic light-emitting diodes and photochemical switches. Statistical synthesis of simple symmetrical HABs is known via low-yielding cyclotrimerization or Diels-Alder reactions. By contrast, the synthesis of more complex, asymmetrical systems, and without involvement of statistical steps, remains an unsolved problem. Here we present a generally applicable synthetic strategy to access asymmetrical HAB via an atom-economical and high-yielding metal-free four-step domino reaction using nitrostyrenes and α,α-dicyanoolefins as easily available starting materials. Resulting domino product – functionalized triarylbenzene (TAB) - can be used as a key starting compound to furnish asymmetrically substituted hexaarylbenzenes in high overall yield and without involvement of statistical steps. This straightforward domino process represents a distinct approach to creating diverse and still unexplored HAB scaffolds, containing six different aromatic rings around central benzene core.
Trans-cis Photoisomerization of Biomimetic Cyclocurcumin Analogous Rationalized by Molecular Modelling
Authors: Losantos Raúl , Pecourneau Jeremy , Mourer Maxime , Parant Stephane , Pasc Andreea , Monari Antonio
Published: March 2021

Cyclocurcumin is a natural compound extracted from turmeric and showing, in addition to antiinfective, antibacterial, and intinflammatory capabilities, solvent-dependent phtoswitching ability. The solvent-dependent photochemistry of cyclocurcumin has been rationalized on the basis of a competition between π-π* and n-π* states. Recently we have reported the synthesis of a biomimetic analogous showing enhanced photochemical properties and in particular presenting photoswitching capacity in various media. In the present contribution we rely on the use of molecular modeling and simulation, incuding density functional and wavefunction based methods to explore the excited states potential energy surface landscape. We see that the addition of a carbon-carbon double bond to the core of the natural compounds favors the population of the π-π* state, whatever the choice of the solvent, and hence leads to photoisomerisation, with fluorescence reduced to only a minor channel, rationalizing the experimental observations. In addition, the two photon absorption cross section is also strongly increased compared to the parent compound, paving the way to the use in biologically oriented applications.
Electrochemical Nozaki–Hiyama–Kishi Coupling: Scope, Applications, and Mechanism
Authors: Gao Yang , hill david , hao wei , McNicholas Brendon J. , Vantourout julien , Hadt Ryan , Reisman Sarah , Blackmond Donna , Baran Phil
Published: March 2021

One of the most oft-employed methods for C–C bond formation involving the coupling of vinyl-halides with aldehydes catalyzed by Ni and Cr (Nozaki–Hiyama–Kishi, NHK) has been rendered more practical using an electroreductive manifold. Although early studies pointed to the feasibility of such a process those precedents were never applied by others due to cumbersome setups and limited scope. Here we show that a carefully optimized electroreductive procedure can enable a more sustainable approach to NHK, even in an asymmetric fashion on highly complex medicinally relevant systems. The e-NHK can even enable non-canonical substrate classes, such as redox-active esters, to participate with low loadings of Cr when conventional chemical techniques fail. A combination of detailed kinetics, cyclic voltammetry, and in situ UV-vis spectroelectrochemistry of these processes illuminates the subtle features of this mechanistically intricate process.
Seed Mediated Synthesis of Colloidal Halide Perovskite Nanoplatelets
Authors: Guvenc C. Meric , balci sinan
Published: March 2021

Two-dimensional lead halide perovskite nanoplatelets (2D LHP NPLs) have been emerging as one of the most promising semiconductor nanomaterials due to their narrow absorption and emission line widths, tunable bandgaps, high exciton binding energies, high defect tolerance as well as highly localized energy states. Colloidal synthesis of 2D LHP NPLs is generally performed using hot-injection or ligand assisted precipitation techniques (LARP). In the LARP method, perovskites are synthesized in polar solvents, which decrease the stability of the 2D LHP NPLs due to their weakly bonded nature. In fact, the presence of residual polar solvent in the LHP NPL colloid can cause deterioration of thickness uniformity, degradation of NPLs to parent precursors, and undesired phase transformations. Herein, for the first time, we report facile seed-mediated synthesis route of monolayer, 2-monolayers, and thicker lead halide perovskite nanoplatelets without using A site cation halide salt (AX; A = Cesium, methylammonium, formamidinium and, X = Cl, Br, I) and long chain alkylammonium halide salts (LX; L = oleylammonium, octylammonium, butylammonium and, X = Cl, Br, I). The seed solution has been synthesized by reacting lead (II) halide salt and coordinating ligands (oleylamine or octylamine and oleic acid) in nonpolar high boiling solvent (1-octadecene). The seed mediated synthesis has been carried out in hexane by reacting seed solution with A-site cation precursors (Cs-oleate, FA-oleate, or diluted MA solution in hexane) under ambient conditions. More importantly, the seed mediated growth of NPLs has been tracked for the first time by performing in-situ optical measurements. Furthermore, the optical properties and morphologies of the seeds have been extensively studied. We find that our facile synthesis route provides highly stable, monodisperse NPLs with narrow absorption, and photoluminescence line widths (68-201 meV), and high PLQY (37.6-1.66% for 2ML NPLs). Furthermore, anion exchange reactions have been performed by mixing pre-synthesized LHP NPLs with counter halide seeds. The optical properties of NPLs have been affectively tuned by postsynthetic chemical reactions without changing the thickness of the NPLs. We anticipate that our new synthetic route provides further understanding of growth dynamics of LHP NPLs.
Prevalence of self-reported halitosis and associated factors in 15 years old male students in Karbala City-Iraq
Authors: Alawsiy Rafal  A , MH. Radhi Nada  J
Published: March 2021

Background×ƒ Halitosis is a common condition and is most often caused by a buildup of bacteria in the mouth because of gum disease, food, or plaque. It can result in anxiety among those affected, it is also associated with depression and symptoms of obsessive compulsive disorder. The aim of this study isto assess the prevalence of self-reported halitosis and associated factors (dental plaque, gingival condition and dental caries) in 15 years old male students in Karbala city in Iraq. Additionally, we studied adolescentsâ€™ concern with their own breath and whether anyone had ever told them that they had halitosis. Methods×ƒ A cross sectional observational survey was conducted to15 years old high school students from public and private schools in the city of Karbala, Iraq. The random sample consisted of 400 adolescents from 44 schools. An interview with a structured questionnaire was administered along with measurement of oral parameters (PI, GI, DMF). Results×ƒ The prevalence of self-reported halitosis was 48.50% according to question one. Prevalence of halitosis according to total score of questionnaire was 86.5%. 13.5% reported that they didnâ€™t have halitosis. It is concluded that there is high prevalence of self-reported halitosis, which is associated with a socioeconomic pattern. Most adolescents report concern with their own breath. Dental plaque and gingival status are associated significantly with self-reported halitosis. The high prevalence of self-reported halitosis according to questionnaire among the students may be due to the consumption of garlic or spicy food, in addition dental plaque, gingivitis and dental caries cause increase in volatile silver compound level which cause increase in halitosis. Conclusion×ƒ Self-reported halitosis is a prevalent situation in about 50% of adolescents in Karbala city. Patientsâ€™ self-reported halitosis is found to be associated with dental plaque, gingivitis and dental caries.