bluuebunny/crossref_metadata_2025 huggingface dataset:
The Relationship among Socioeconomic Factors in the Western Region and Eastern Region of Indonesia
Authors: Mire Muhammad Saleh , Hasan Muhammad , Gaffar Emmilya Umma A.
Published: February 2024

The research aim was to study the influence of industrial development, wages, education, training institutions and MSMEs on unemployment in the western and Eastern regions of Indonesia. Indonesia is can be divided into two regions, western Indonesia and eastern Indonesia to make comparisons regarding economic growth and unemployment. The results of the analysis show that the industrial developments have no influence on economic growth in either the western region or the eastern region. Industrial development has a significant positive influence on unemployment both in Western and Eastern Indonesia. Economic growth has a significant negative influence on unemployment both in Western Indonesia and Eastern Indonesia. Apart from that, wages have an insignificant positive influence on economic growth and unemployment in both Western and Eastern Indonesia. The influence of education on economic growth is positive and significant in Western Indonesia but has no effect in Eastern Indonesia. Furthermore, the effect of education on unemployment is positive and very significant in both regions of Indonesia. On the other hand, training has no effect on economic growth and unemployment in the two regions of Indonesia. Lastly, Micro Small Medium Enterprises (MSMEs) had a positive effect on economic growth and unemployment in western Indonesia but had no influence in western Indonesia
Identidad y apropiación en la hipercultura
Authors: Baquero Mejía María Camila
Published: February 2024

En una contemporaneidad marcada por la multiplicidad cultural, el filósofo asiático Byung-Chul Han presenta su propuesta sobre la Hipercultura. Este texto se desarrolla en torno al libro homónimo del autor, desglosando específicamente sus tesis y consideraciones respecto a la apropiación y la identidad, y por extensión, sobre los conceptos de «otro» y «otredad», abordados conforme a las definiciones ofrecidas por Tenorio (2003). Una vez abordados los modos en los que se conciben estos elementos, las tesis del autor son extrapoladas y aplicadas al campo del arte, específicamente a la música como unidad de representación de la identidad y de apropiación potencialmente agresiva, centrada en la exportación de ritmos latinoamericanos. Aunque se exponen los términos en los que se plantea la hipercultura, se consideran también características de la interculturalidad, la multiculturalidad y la transculturalidad, que igualmente competen al fenómeno cultural como constituyente de la individualidad y la colectividad.
Performance Evaluation of a Locally Fabricated Roasted Groundnut Dehuller.
Authors: Ayodele M. B. , Agbetoye L. A. S , Lawson O. S.
Published: February 2024

A locally fabricated roasted groundnut dehulling machine was evaluated for performance under three different speeds of 30, 40 and 50 rpm, and three crop moisture contents of 8%, 9% and 10% using three common varieties of groundnuts (Runner, Red Valencia and Kampala). The components of the dehuller include the hopper, a specially designed dehulling chamber, sprout orchute/outlet, frame and an electric motor-driven belt-pulley drive power transmission mechanism. The test results showed that the dehuller’s operating speed and the roasted groundnut moisture content have significant effect on the mechanical damage and the dehulling efficiency. The efficiency of the dehuller decreased with increase in speed. It attained the highest efficiency of 92.1% at 9% moisture content and at an operating speed of 30 rpm, while the mechanical damage was minimal(1.86%) in the runner groundnut variety. All the materials used for fabrication were sourced locally. The dehuller has a capacity of 5.3 kg/h of roasted groundnut seeds. It is affordable, costing about four hundred and two thousand, two hundred Naira (N402,200 equivalent to US$335.17 at the rate of N1,200 to US$1) to produce, simple to operate, suitable for domestic uses and is also recommended for both small and medium scale roasted groundnut processors. The study provided useful information on the effective and efficient optimum conditions required for roasted groundnut dehulling. Further studies are suggested for further investigation by adopting the techniques used in this study for dehulling other similar crops.
Prinsip Perintisan Jemaat Sebagai Refleksi Gereja Tuhan Masa Kini
Authors: Andris Kiamani  , Aska Aprilano Pattinaja
Published: February 2024

Perintisan jemaat merupakan sesuatu yang sangat penting bagi pelayanan masa kini. Sekalipun penting, namun pada kenyataannya terdapat gereja-gereja yang memandang bahwa perintisan jemaat adalah tugas dari penginjil, hamba Tuhan, bagian gereja atau denominasi tertentu saja. Hal ini dikarenakan gereja berada dalam zona nyaman untuk lebih sibuk untuk memperhatikan pelayanan kedalam dan mengabaikan perintisan jemaat-jemaat baru. Banyak penelitian yang telah dilakukan dalam mengkaji tentang perintisan gereja atau jemaat, tetapi penelitian ini menemukan, belum adanya penelitian yang secara khusus dan komprehensif, mengenai prinsip perintisan gereja. Oleh sebab itu, penelitian ini dilakukan untuk meletakkan dasar bagi pemahaman yang benar, berdasarkan kebenaran Alkitab terhadap pentingnya prinsip perintisan jemaat sebagi sebuah refleksi gereja Tuhan masa kini. Dengan menggunakan metode kualitatif deskriptif, maka penelitian ini menemukan, lima prinsip penting perintisan jemaat, yakni: pertama visi dari Tuhan; kedua tempat tujuan untuk memulai; ketiga mengikuti perintah Tuhan; keempat menunggu waktu Tuhan; dan kelima memiliki iman yang radikal akan janji-Nya. Iman adalah bagian terpenting untuk menarik janji Tuhan agar terjadi secara nyata.
Karya-karya Roh Kudus dalam Kehidupan Orang Percaya: Studi Tematik Roma 8: 1-39
Authors: Sorongan Yosua , Tampilang Petra Harys Alfredo
Published: February 2024

Topik mengenai Roh Kudus merupakan topik yang sering diperbincangkan di kalangan orang-orang Kristen sampai sekarang ini. Mempelajari karya Roh Kudus sama pentingnya dengan mempelajari karya keselamatan di dalam Yesus Kristus, karena Roh Kudus itu hadir dan berkarya menindaklanjuti pekerjaan Yesus. Penelitian artikel ini bertujuan untuk menemukan karya-karya Roh Kudus dalam kehidupan orang percaya menurut Roma 8:1-39. Analisa penelitian ini menggunakan studi tematik dengan model teologi sistematika, karena peneliti melihat teks Roma 8:1-39 memberikan pemahaman mengenai karya-karya Roh Kudus dan kontribusinya dalam kehidupan orang percaya bila dilihat secara tematik. Sehingga artikel ini menemukan karya-karya Roh Kudus sebagai berikut: Pertama, karya Roh Kudus dalam keselamatan. Kedua, karya Roh Kudus dalam melawan kedagingan. Ketiga, karya Roh Kudus dalam pergumulan hidup. Karya-karya Roh Kudus yang ditemukan di dalam teks Roma 8:1-39 ini dapat diimplikasikan bagi kehidupan orang percaya di masa kini, yaitu: Pertama, orang percaya hidup bersyukur. Kedua, orang percaya hidup benar. Ketiga, orang percaya tidak boleh diliputi ketakutan.
Makna Teologis Ungkapan Mata Adalah Pelita Tubuh Berdasarkan Lukas 11:33-36 dan Implikasinya Bagi Pengguna Media Sosial
Authors: Wulandari Margaretha Cristiani , Lelono Joko , Sarungallo Rahel Rati
Published: February 2024

Penulisan karya ilmiah ini dilatarbelakangi oleh beberapa permasalahan yang muncul seiring dengan perkembangan dunia di era serba internet.   Tidak dipungkiri bahwa dengan adanya perkembangan ilmu pengetahuan dan teknologi, segala pekerjaan manusia menjadi lebih mudah. Baik dalam hal komunikasi, informasi, dan lainnya. Semuanya dapat dilakukan dengan serba cepat. Ternyata, baik disadari maupun tidak, pengaruh ilmu pengetahuan dan teknologi sudah masuk ke dalam gereja-gereja. Orang percaya dituntut untuk menjadi bijak dan berhikmat sehingga tidak hanya berpengetahuan tapi juga takut akan Allah. Allah adalah yang utama dari segala pengetahuan yang manusia miliki.  Mengikuti perkembangan tapi tidak terbawa arus yang buruk, karena hikmat yang berasal dari Allah membawa kita orang Kristen kepada pengertian yang benar dan tidak terbawa arus dunia.
An Architectural Design Process Experience with a Studio Work in the Context of Local Culture
Authors: KUYRUKÇU Zafer
Published: February 2024

In the globalizing world, the transfer of the cultural fabric of cities and regions, urban landscapes, to future generations is deemed a pivotal issue. Imitative endeavors, crafted to pass on local culture through architectural works, not only breed misunderstandings of the local culture but also impede architectural development. The incorporation of local culture into original architectural works and its fusion with modern architecture has emerged as a formidable design challenge. The transmission of this design challenge and the associated awareness to architects can be achieved by emphasizing the subject in studio education. In this context, a boutique hotel design project was executed in Sille, a historic settlement, as part of the Konya Technical University Department of Architecture Studio 4 course during the 2022-2023 Spring Semester. Throughout the course, students were tasked with developing projects within the framework of the concept of ‘place’. The expectation was for students not only to grasp the concept of ‘place’ but also to comprehend its seamless integration into the architectural project and resolve the spatial organization of the hotel. At the end of the semester, six student projects were selected and evaluated within the scope of the study. The analysis of project proposals revealed that while students demonstrated an understanding of the concept of ‘place’, there was a partial inadequacy in effectively reflecting the local culture in their architectural projects. In this regard, it may be considered to add other course(s) to the curriculum to support the design process, especially to enable students to grasp the relationship more easily between local culture and architecture.
IMPLEMENTASI PENGELOLAAN SAMPAH
Authors: Apriani Gradila
Published: February 2024

Pengelolaan persampahan suatu kota bertujuan untuk mengurangi sampah yang dihasilkanpenduduknya, yang secara tidak langsung turut memelihara kesehatan masyarakat serta menciptakansuatu lingkungan yang bersih. Saat ini pengelolaan persampahan menghadapi banyak permasalahanterutama akibat semakin besarnya timbulan sampah yang dihasilkan masyarakat baik produsen maupunkonsumen. Keterlibatan pemerintah sangat dibutuhkan dalam kegiatan operasional persampahan,meliputi tahap pengangkutan, pengolahan, pembuangan akhir, dan pemanfaatan sampah. Tujuan penelitianini untuk mengetahui implementasi dalam pengelolaan sampah ditinjau dari komunikasi serta sarana danprasarana.
Analisis Kebutuhan Tulangan Kolom dan Balok pada Tribun Penonton Stadion Mini Pancing Provinsi Sumatera Utara
Authors: Ailing Resolina , Qarinur Muhammad
Published: February 2024

Analisa kebutuhan tulangan untuk pekerjaan kolom dan balok penting dilaksanakan untuk mengantisipasi kekurangan dan kelebihan tulangan yang akan direncanakan. Pada penelitian ini, analisis kebutuhan tulangan dilakukan pada Stadion Mini Pancing Provinsi Sumatera Utara. Dalam mengoptimalkan penggunaan besi tulangan digunakan suatu metode, salah satunya metode yang sering digunakan yaitu Bar Bending Schedule (BBS). BBS adalah suatu metode yang memuat daftar model pola-pola pemotongan besi tulangan yang berfungsi untuk mengontrol pemakaian besi tulangan dan meminimalkan sisa material dengan bantuan aplikasi Microsoft Excel. Hasil dari analisis volume kebutuhan tulangan pada kolom dan balok menggunakan sambungan konvensional adalah 54.830,96 kg, sedangkan hasil dari analisis volume kebutuhan tulangan pada kolom dan balok menggunakan sambungan kopler adalah 53.523,57 kg. Hasil perbandingan volume kebutuhan tulangan pada kolom dan balok menggunakan sambungan konvensional dengan sambungan kopler adalah 2,3 %. Hasil perhitungan kebutuhan biaya penulangan kolom dan balok menggunakan sambungan konvensional adalah Rp743.507.817,60 sedangkan sambungan kopler adalah Rp725.688.195,00. Oleh karena itu dapat disimpulkan sambungan kopler lebih efisien untuk digunakan dibandingkan sambungan konvensional dari segi biaya.
Criminal Justice Reforms and Human Rights in Pakistan: A Comparative Analysis with Australia, the UK, and Canada
Authors: Islam Muhammad , Watto Omer Mahmood , Hussain Syed Arshad , Sarfraz Muhammad
Published: February 2024

This study compares criminal justice reforms and human rights in Pakistan juxtaposed with Australia, the UK, and Canada, emphasizing the reforms' role in supporting human rights. It evaluates how these reforms contribute to fair trials and humane treatment in the justice system, examining Australia's indigenous rights focus, the UK's digital advancements, and Canada's restorative justice. The aim is to highlight effective practices and challenges to improve global justice systems and stress the collective endeavors required to promote human rights in criminal justice.
Impact of Financial Distress on Earnings Management with the Moderating Role of Audit Quality: Evidence from Pakistan
Authors: Kazmi Syed Taha Fraz Haider , Rasheed Burhan , Malik Zohair Farooq , Shakeel Amer , Gulzar Muhammad
Published: February 2024

The core aim of the financial reports is to provide a firm’s annual results of financial performance and position to stakeholders on time. Several accounting scandals led to the default of many large-scale corporations, leading to investors’ lack of confidence in the reliability of financial information and also putting a question mark on the effectiveness of internal control mechanisms and external audits. Business managers of financially distressed firms use the choice of accrual accounting methods which gives them leverage to misuse their powers and expropriate stakeholders by showing good financial results. So, this study fills this gap by investigating the presence of Financial Distress (FD) and its effect on Earnings Management (EM) with the moderating role of Audit Quality (AQ). The sample of this study contains the data of 96 non-financial listed companies for the period 2017-2022 on the Pakistan Stock Exchange (PSX). This study uses the discretionary accruals as a proxy for the EM and Z-score for FD. The results and analysis find that FD and EM have a significant positive relationship, which reveals that corporate managers of distressed companies do EM while AQ weakens this relationship. This study recommends that professional bodies, regulatory authorities, and corporate governance institutions must design policies that restrict corporate managers from getting involved in earning management practices, especially in the time of FD.
A Comprehensive Farm Efficiency Analysis of Apple Growers in Newley Merged District South Waziristan
Authors: Ullah Zahid , Hassan Sarfraz , Abbas Azhar , Ullah Raza
Published: February 2024

In the apple-producing land of South Waziristan’s three tehsils, Wana, Bermal, and Tiarza, this research paper is designed to analyze farmers' efficiencies, e.g., production, allocative and technical dimensions. Through a Data Envelopment Analysis (DEA) framework, the study evaluates the performance trajectories of 304 apple growers. A multistage sampling technique was used for the farmer’s interview. To the researcher’s knowledge, there is no detailed efficiency analysis of South Waziristan’s apple growers in existing literature, so there is a need to investigate the factors affecting efficiencies in the targeted area. The researcher is therefore encouraged to conduct a study of the farm efficiency of apple growers in South Waziristan. Apple growers' efficiencies were categorized as technical, allocative, and economic efficiency using the DEA approach. Results of the study show that there were tremendous inefficiencies of apple growers, which need to be reduced. This study sheds light on optimal resource allocation, productivity dynamics, and efficiency frontiers within apple cultivation in South Waziristan. The research offers an understanding of agricultural practices, resource utilization patterns, and efficiency benchmarks. The empirical insights derived from this comprehensive analysis facilitate informed decision-making among farmers and provide policymakers, agricultural stakeholders, and development practitioners with actionable recommendations to enhance agricultural productivity, sustainability, and socio-economic well-being in the region. Through empirical evidence and contextual relevance, this paper contributes significantly to the evolving discourse on agricultural efficiency analysis and underscores the imperative of tailored interventions for optimizing apple cultivation practices in South Waziristan.
Diversidad en el neurodesarrollo
Authors: De Leo Jiménez José Oliver , Rodríguez Santillán Elizabeth , Carbajal Valenzuela Cintli Carolina , García Gomar María Luisa , Castro Alameda Ana Jazmín , Negrete Cortés Agustín Jaime , Moreno García Martha Beatriz , Nila Macedo Zitlali Betzabeth , García Martínez Fabiola , Calderón Carrillo Melissa , Piñón Díaz Ana Cristina , Gutiérrez Hernández Claudia Calipso , Domínguez Sandoval Guadalupe , Delgado Bustamante Rafael Iván
Published: February 2024

El libro que tiene en sus manos describe detalladamente cómo los múltiples factores biológicos, psicológicos y sociales a los que se expone el sistema nervioso de una persona desde los primeros momentos de su formación hasta el final de su vida (la prematurez, el traumatismo craneoencefálico, el cuidado de los patrones de sueño, los trastornos del neurodesarrollo, etc.) modifican el desarrollo de algunos de los más importantes procesos cognitivos y emocionales; a saber, el desarrollo motor, el procesamiento de rostros emocionales, las funciones ejecutivas, el descuento temporal, la inteligencia, etc. El resultado de estas modificaciones es la amplia gama de posibilidades a las que llamamos “diversidad en el neurodesarrollo” y que profesionales de la educación y de la salud física y mental identifican de forma cotidiana en sus espacios de trabajo. Las autoras y autores de cada capítulo que conforma esta obra son expertas y expertos en cada una de las temáticas que presentan; en su mayoría trabajan investigando y/o interviniendo desde instituciones educativas, psicológicas o de salud, como la Universidad Autónoma de Querétaro, la Universidad Autónoma de Baja California, la Universidad Nacional Autónoma de México, entre otras. El objetivo principal de este libro es ser una fuente de información confiable para los profesionales antes mencionados compartiendo la idea de que la diversidad en el neurodesarrollo no es la excepción sino la regla en la humanidad.
Characterization of Structural, Antimicrobial Activity, of Coriander Seed Oil
Authors: Amer Ibrahim Wijdan , Abdallah Hassan Ekhlas , Al-Zuhairi Wafaa Sh.
Published: February 2024

This study was aimed to investigate the structure of bioactive components of Coriander Seed Oil (CSO) and their antimicrobial eﬀects. Initially, the structural examination was conducted using various spectroscopic techniques, such as FTIR, and UV-visible spectroscopy, which are important in determining substituents, functional groups, and the presence of conjugated double bonds in CSO. From the FTIR spectra, a variety of sharp, strong, and weak peaks were speciﬁed relating to the main components of Linalol, and Decenolin CSO. The results of UV-visible spectroscopy conﬁrmed the presence of Linalool as a major compound, and conjugated double bonds were also found. Furthermore, anti- microbial activity of CSO was studied against various types of bacteria. Strong bacterial inhibitory eﬀects were observed, especially against S. aureus, with an average inhibition zone of 18 mm. It was also found from the structural characterization of CSO that the existence of Linalol is responsible for potential antibacterial activity. The main observation of this work is that CSO has antimicrobial activity even against methicillin-resistant Staphylococcus aureus.
HPTLC Phytochemical Profiling and Simultaneous Quantification of Quercetin and Gallic acid in Neolamarckia cadamba (Roxb.)
Authors: Kumar Srivastav Anant , Verma Shikhar , Awasthi Himani , Kumar Santosh
Published: February 2024

HPTLC analysis of Neolamarckia cadamba (Roxb.) Bosser commonly known as kadamb reveals presence of several bioactive compounds along with percentage of quercetin and gallic acid in the methanolic extract of test samples. Quantification of markers (quercetin and gallic acid) along with phytochemical profiling of Neolamarckia cadamba was done at 254nm and 366nm wavelength through HPTLC CAMAG scanner III. Quantification was done by using peak area and peak height. Chromatograms and tracks obtained reveals that the test samples, sample 1 and sample 2 have quercetin 1.29% and 0.77% respectively. Phytochemical profiling of sample 1 and sample 2 reveals presence of 16 and 10 unknown bioactive compounds respectively denoted by the number of peaks present in chromatograms. As this study acknowledging phytochemical profiling, quantification of quercetin and gallic acid will be accountable for further research towards pharmacognostic and therapeutic value of Neolamarckia cadamba.
Comparison of Antioxidant effects of Polysaccharides of Mixed Microalgae Isolates Glagah Beach Yogyakarta and East Java, Indonesia
Authors: Afililla Zhaza , Pujiyanto Mahendra , Tri Suwanti Lucia , Donny Koerniawan Mochamad , Agus Suyono Eko , Budiman Arief , Juniarti Siregar Ulfah , Puspitasari Heni
Published: February 2024

Indonesia is a country with a large marine and has a very high biodiversity of microalgae. Previous research has identified mixed microalgae from Glagah Beach, Yogyakarta, and several beaches in East Java. This study aims to extract polysaccharides and assessed the antioxidant activity of polysaccharides from those microalgae. Polysaccharides of Spirulina platensis, a mixed microalgae Glagah, and a mixed microalgae East Java were extracted by the alkaline method. The extraction rate and protein and carbohydrate content of polysaccharides of each of microalgae were calculated. The antioxidant activity of polysaccharides was observed in vitro using the DPPH assay method. The highest extraction rate was obtained from Glagah microalgae followed by S. platensis and East Java microalgae with values of 13.575%, 9.75%, and 2.375%, respectively. On the other hand, the carbohydrate content of the polysaccharides from Glagah microalgae was the lowest, followed by S. platensis and East Java microalgae, 1.2 mg/mL, 13.33 mg/mL, and 21.925 mg/mL, respectively. The protein content in polysaccharides from Glagah microalgae was the highest, followed by East Java microalgae and S. platensis the lowest, 2.23 mg/mL, 1.01 mg/mL, and 0.67 mg/mL, respectively. Based on the results of IC50 values, the antioxidant activity of mixed microalgae polysaccharides from Glagah and East Java was included in the active/moderate category, 125.21 µg/mL and 127.11 µg/mL, respectively, while the antioxidant activity of polysaccharide S. platensis was low, 171.82 µg/mL. In conclusion, Glagah and East Java Microalgae Polysaccharides have the opportunity to be promoted as health ingredients to overcome free radicals.
Construction of Peptide Vaccine Candidate Based on β-Cell Epitopes of Indonesian Monkeypox Virus (MPXV) Virulence Protein:A Reverse Vaccinology
Authors: Dhea Kharisma Viol , Ansori A. N. M. , Affan Ali Murtadlo Ahmad , Hermawan Widyananda Muhammad , Emdad Ullah Md. , War Naw Sin , Jakhmola Vikash , Dobhal Kiran , Parashar Tarun , Rebezov Maksim , Zainul Rahadian
Published: February 2024

Infection with a DNA virus called monkeypox virus (MPXV) in humans has been identified in the Congo since 1970. Antiviral drugs are not effective for preventing MPXV infection. MPXV infection cases in Indonesia are very low but MPXV has the potential to become a global pandemic so it is very important to do prevention such as vaccine development. This study aims to construct a B cell epitope-based peptide vaccine candidate in Indonesian MPXV through an in silico approach.The development of the MPXV vaccine can be performed through a computational approach for preliminary studies. In silico-based construction of vaccines using B cell epitopes, antigenicity, allergenicity, docking, and molecular dynamics analysis have been used by researchers and scientists in solving viral infection cases. We recommend Pep A and Pep D as vaccine candidates because they allow recognition by B cells, antigenic peptides, non-allergenic and non-toxin. Peptide vaccine candidate can trigger B-cell activation to produce IgM isotype-specific antibodies through BCR interaction. In summary, the results of this study can be used for an initial study of MPXV vaccine development in Indonesia.
Analysis of Identified risks in the release of over-the-counter medicines to Teenagers
Authors: Sinitsyna Anastasia , Denisova Maria , Litvinova Tatyana , Glazkova Irina , Savinova Olga , Babaskin Dmitrii
Published: February 2024

Despite the absence of prohibiting legal norms in Russia, pharmaceutical workers often refuse to sell over-the-counter medicines to teenagers, guided by the unspoken rules of the pharmacy or the internal moral and ethical code. The purpose of this study was to identify and assess the main types of risks faced by pharmaceutical workers when dispensing medicines to teenagers. The assessment and identification of risks were carried out using the Delphi methods and a questionnaire in which 186 respondents took part (the representativeness of the sample was calculated using the statistical method). The probability of occurrence of risks and the degree of criticality of the consequences of the risk was assessed. The experts stated that the most likely event would be a teenager buying the wrong medicine (a medicine other than the one that the teenager or the persons who asked them to buy it were planning to obtain), with a different trade name, dosage, or formulation, followed by a possible conflict with the child's representatives with a request to return or exchange the medicine. Besides, highly probable events include the use of information obtained from unverified sources, including peer advice and information obtained from social networks, by the teenager. The experts named the purchase of medicines by teenagers for self-poisoning the most critical risk factor. The experts considered the risk of using psychoactive substances an event with a high degree of consequences. The experts considered the improper use of medicines by teenagers to be the least risky event. The risks were ranked using a risk matrix by the following categories: negligible, acceptable, moderate, significant, and unacceptable.
Dynamic Tracking to Identify Topics and Thematic Evolution of Obsessive-compulsive disorder as an Emerging Topic
Authors: Bakhshinejad Behnaz , Khazaneha Mahdiyeh , Mehrabani Mitra , Sabahi Abdolreza , Sadatmoosavi Ali , Tajedini Oranus , Esmaeili Omid , Mehrbani Mehrzad
Published: February 2024

This study aims to draw a science map, provide structural analysis, explore the evolution, and determine new trends in research articles published in the field of obsessive-compulsive disorder (OCD). The articles published from 1981 to 2021 were retrieved by searching the related keywords in multiple databases including PubMed, Scopus, and Web of Science, according to their thematic coverage and scope. The papers were analyzed using R and SciMAT software. A total of 1820 articles were analyzed and 4191 keywords plus, and 3242 author keywords were reported in the journals. Moreover, 7482 authors contributed in conducting these studies, of which 111 articles were written by single authors, and the collaborative coefficient was 4.36. Neuropsychopharmacology, International Clinical Psychopharmacology, and Journal of Clinical Psychopharmacology are the most significant journals publishing OCD articles. This study uncovered new insights into the evolution trend of the leading research stream on OCD over the past years. The findings of this study can contribute to developing the OCD Global Research Program and policymakers.
MMP-7 Levels Decrease in Gingival Epithelium Exposed to Porphyromonas Gingivalis after Curcumin administration
Authors: Krismariono Agung , Purnama S Carolyn
Published: February 2024

Periodontitis is an irreversible inflammatory disease of the periodontal tissues. The leading cause of periodontitis is Porphyromonas gingivalis bacteria, which secretes virulence factors, namelyLipopolysaccharide (LPS) and proteases, which cause the inflammation of gingival junctional epithelium and loss of attachment, resulting in the formation of a periodontal pocket. The most common type of MMP found in the junctional epithelium is MMP-7. Invasion of Porphyromonas gingivalis bacteria causes an increase in proteolytic activity on the expression and activation of MMP-7, which causes loss of attachment. Efficacious plant extracts, namely irrigated curcumin 1%, have an anti-inflammatory effect. This research is independent research using experimental white rats (Rattus norvegicus) male strain Wistar, 20 weeks old, with a body weight of 325-350 grams. This research is to see the levels of MMP-7 with the ELISA method. Forty-eight periodontitis model rats were divided into two groups. Twenty-four periodontitis model rats as the control group were exposed to Porphyromonas gingivalis, and another twenty-four periodontitis model rats as the treatment group were exposed to Porphyromonas gingivalis and 1% curcumin irrigation. Each group was observed at 24 hours, on days-7 and days-14. The results showed that MMP-7 levels in the treatment group were significantly lower than in the control group on on days-7 and days-14. In the treatment group, MMP-7 levels at 24 hours were significantly lower than on the on days-7 and days-14. In the treatment group, MMP-7 levels did not experience a significant difference between the on days-7 and days-14. The results of this study indicate that 1% curcumin can reduce MMP-7 levels in cases of chronic periodontitis due to Porphyromonas gingivalis bacteria.
Factors affecting the fear of recurrence in Breast cancer patients
Authors: Kussainova Dinara , Tursynbekova Anar , Aimbetova Gulshara , Bagiyarova Fatima , Kaidarova Dilyara
Published: February 2024

The fear of cancer recurrence is defined as a mental state of anxiety or concern that cancer may return or spread. It is assumed to be the commonest unpleasant psychological disorder among cancer survivors. Breast cancer is assumed to be one of the commonest cancers in women. Also, the treatment modalities for breast cancer are strongly developed and there is an increase in the cure rate in recent years. However, surviving cancer patients are still feared of recurrence of the neoplasm. The fear of cancer recurrence affected negatively the patients' health and lowered their quality of life. Therefore, we sought to establish effective preventive strategies to improve the psychological health of patients. We searched the literature and reviewed the most recent available data from 2017 to 2023 to clarify the different factors affecting the fear of cancer recurrence in breast cancer patients.We identified different factors that increase the fear of cancer recurrence in breast cancer patients including; anxiety, chemotherapy, avoidance, intrusive thoughts, distress and exhaustion. Also, we identified other factors that decrease the fear of cancer recurrence in breast cancer patients including; younger age patients, having a good quality of time, good social support and good self-efficacy. Regarding preventive measures; our meta-analysis showed that breast cancer patients who underwent Mindfulness-Based Stress Reduction had significant improvements on the Center for Epidemiological Studies-Depression scale (P<0.0001), State-Trait Anxiety Inventory scale (P=0.0002) and perceived stress scale (P=0.0004). Also, we noticed that breast cancer patients who underwent blended cognitive behavior therapy or Smartphone problem-solving therapy had lower fear of cancer recurrence than those who received usual care. Finally, we advocate more research articles applying different modalities to overcome FCR in patients with breast cancer. Also, we recommend the use of different psychological treatments for patients with breast cancer to decrease their fear of cancer recurrence and improve their health.
Correlation between Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio with the severity of Covid-19 patients in Dr. Hasan Sadikin Central Public Hospital
Authors: Valentina Yuniati , Suraya Nida , Lismayanti Leni
Published: February 2024

Coronavirus Disease 2019 (COVID-19) has a clinical spectrum that varies from asymptomatic to death. Cytokine storms cause neutrophilia, lymphopenia, and thrombocytopenia at various levels of COVID-19 severity. These three parameters can be studied as markers of inflammation in the form of ratios. This study aims to discover the correlation between NLR & PLR inflammatory markers in determining the severity of COVID-19.An analytical cross-sectional study was carried out on secondary data from 274 subjects collected from the subject's hematological parameters from first day of admission to Hasan Sadikin Hospital from May-December 2020. The statistical analysis with Spearman test using the SPSS 17.0 program. There are 274 subjectswith non-severe and severe COVID-19 were NLR (3,44 vs 7,17), PLR (182,4 vs 254,4). The r coefficient of NLR and PLR reached 0.308 and 0.198, p-value of < 0.001.In the next phase, days 7-14, lymphocytes decrease significantly. This study found a weak correlation because neutrophilia occurred on the third-seventh day of treatment, while the assessment was performed at first day of admission with clinical symptoms on day 1-3. PLR and NLR have a weak positive correlation with the severity of COVID-19. Therefore, it cannot be utilized independently in determining the severity of COVID-19.
Comparison between Rapid and Standard procedure Pleurodesis outcome in Malignant Pleural Effusion
Authors: Anang Marhana Isnin , Dwi Wahyudi Andri , Nur Rosyid Alfian
Published: February 2024

Background: The terminal stage of cancer with distant metastasis often concurrent with malignant pleural effusion (MPE), which is the complication in lung cancer cases. Pleurodesis was performed by inserting a sclerosing agent through the thoracal drain after the pleural fluid was evacuated. Objective: to determine whether rapid pleurodesis is more efficient and effective than the standard procedure pleurodesis in MPE patients. Methods: This experimental study using randomized posttest-only control group design and divided into two groups (standard procedure pleurodesis group and rapid pleurodesis group). All of the samples were inpatient with MPE requiring pleurodesis and eligible with the inclusion criteria as samples. Pleurodesis procedure was performed by inserting a sclerosing agent through the thoracic drain after fluid well evacuated using talc slurry, and evaluated 1 month after pleurodesis procedure. All data were analyzed using SPSS software. Results: A total of 25 samples were included in this study. Our study suggests that standard procedure findings were the same as the rapid group (90.9% vs. 81.81%; p = 0.30). But the rapid group was had a shorter length of stay compared with the standard group (24.62 vs. 29.08 days; p = 0.42) and cheaper (USD 1,700 vs. USD 1,876; p = 0.98). Pain and fever were common complications in both groups. Conclusions: Rapid and standard pleurodesis groups showed the same efficiency and effectivity rates in treating MPE patients. However, the rapid pleurodesis group has a shorter length of stay and cheaper, but there was no statistically difference.
Study of Red Algae (Eucheuma denticulatum (Burman) Collins et Harvey) Extract Bioactive Compounds using Liquid Chromatography Mass Spectroscopy - Mass Spectroscopy
Authors: Syakri Syamsuri , Sartini Sartini , A. Miskad Upik , Aminuddin Aminuddin
Published: February 2024

Research has been carried out on the Study of Red Algae (Eucheuma denticulatum (Burman) Collins et Harvey) Extract Bioactive Compounds Using Liquid Chromatography Mass-Mass Spectroscopy (LCMS-MS). This study aims to determine the bioactive compounds produced in this red algae extract by means kinetic maceration of extraction. Reading of bioactive compounds using LCMS-MS to obtain compound results, compound structures, and molecular weights. The results show that there are 22 bioactive compounds contained in this plant. Consist of : 4-Dodecylbenzenesulfonic acid, NP-009092, 6-Hydroxycaproic acid, Xanthine, 3-Phenyilactic acid, Azelaic acid, Apro barbital, Decosahexaenoic acid, Methil hydrogen Phenylphoshonate, (1S)-1-Carboxy-N,N,N-trimethyl-2-(2-thioxo-2,3-dihydro-1H-imidazol-4-yl)ethanaminium, D-(+)-Tryptophan, uracil, ?17-6-keto Prostaglandin F1, Hypoxanthine, 20-hydroxy Prostaglandin F2?, 2-Hydroxy-4-methylthiobutanoic acid, N-(2-Furylmethyl)-3-[(2S,5aS,8aR)-1-methyl-5-oxodecahydropyrrolo[3,2-E][1,4]diazepin-2-yl]propanamide, 6-Hydroxycaproic acid, Methaphenilene, 15(S)-HpEPE, [(4Z)-5-(Methylsulfanyl)-4-penten-2-yn-1-yl]benzene, Suberic acid.
Impact of Breathing exercise and Inhalation Technique on patient’s Quality of Life among Asthma and COPD patients
Authors: Biradar SM. , Kumar C Vineeth , Sainadh K , Kumar NS Vinay , Avinash P , Ambali AP. , Devaramani Shashidhar , Naikwadi Akram , B Abhishek , Awasthi SR. , Jorapur Prashanth
Published: February 2024

Around 4 million deaths each year are caused by respiratory disorders worldwide. These diseases are a persistent threat to India as well; the number of people in India who suffer from COPD and asthma has been estimated to be 14.84 million and 17.23 million, respectively.In the present prospective and observational study, a total of 120 patients were enrolled, among 38 patients were diagnosed with Asthma and 82 were COPD patients. All the patients were trained with breathing exercises and inhalation techniques. The patients who have been prescribed with DPI and MDI inhalation devices were checked for their correct usage. The checklist score (DPI and MDI) for Asthma patients, before trainingwas 2.9 and after training was 8.1(<0.001***) and checklist score for COPD patients, before training was 2.8 and after training was 8.5(<0.001***).The results indicate that there is a significant increase (<0.001***) in correct usage after training session, which influences the inspiratory flow rate on Respirometer. Asthma Patient’s QoLwas measured by using ACT score, before training was 9.3 and after training was 19.7(<0.001***) and AQLQ score before training was 35.6 and after training was 74.1 (<0.001***). For COPD Patient’s QoLwas measured by using CAT score, before training was 33.2 and after training was 12.1(<0.001***) and MMRC score before training was 3.6 and after training was 1.4(<0.001***). In the present study breathing exercises increases inhalation capacity and hands on training for inhalation techniques improves the efficacy of drugs, together influences the patient’s Quality of Life (QoL) which reduces the number of days of hospitalization and socio-economic burden.
Formulation and Evaluation of Febuxostat Transdermal Patch for Management of Gout
Authors: Naaz Farheen , Majumdar Arti , Malviya Neelesh , Mourya Priya , Dhere Manisha
Published: February 2024

The present research was aimed to formulate a soft and easy to handle transdermal patch consisting simple and cost effective monolithic polymeric film as an attempt to deliver Febuxostat transdermallyand overcome problems associated with its poor bioavailability and hepatic first pass metabolism. Transdermal patches of Febuxostat were prepared by solvent casting method. Prepared formulations were evaluated for various parameters tensile strength, thickness, folding endurance, % moisture content, % moisture uptake, % drug content, % elongation, In vitro drug release. Based on the evaluation of transdermal patches, concluded that the concept of transdermal drug delivery is a novel, nontoxic as well cost-effective technique for enhancing the aqueous solubility and bioavailability of the drug. It can be concluded that transdermal drug delivery works very simple in which drug is applied inside the patch and it is worn on skin for long period of time. By this constant concentration of drug remain in blood for long time. Thus, overcome the adverse effects caused by oral route.
Antidiabetic activity of Akar Kuning (Fibraurea tinctoria Lour) Extract in Alloxan-Induced Diabetic White Male Rats
Authors: Supomo Supomo , Siswanto Syamsul Eka , Saadah Hayatus , Kintoko Kintoko , Astuti Witasari Hardi
Published: February 2024

The Akar kuning (Fibraurea tinctoria Lour) is a well-known plant for its potential for the treatment of liver damage and hyperglycemia. However, the main constituent responsible for the anti-diabetic effect is unknown. This study was conducted to investigate the effect of administration of Fibraurea tinctoria Lour ethanol extract on the blood sugar levels in alloxan-induced diabetic male albino rats. All animals were acclimatized with normal feed, and were subsequently divided into 5groups (3rats/ group). Group 1 (negative control group) was given 0.3% NaCMC; Groups 2, 3, and 4 (treatment groups), were given 50, 100, and 200mg/kg BW of Fibraurea tinctoria Lour ethanol extract, respectively once daily for 15 days, while Group 5(positive control group) received 0.65mg/kg BW glibenclamide. Before the treatments, the rats were induced intraperitoneally with 175mg/kg BW alloxan monohydrate. The blood glucose levels were observed every five days. The results showed that the ethanol extract at the doses of 50, 100, and 200mg/kg BW caused a significant decrease (p <0.05) in the blood glucose levels compared to the negative control group. Also, the highest decrease in the blood glucose level was observed in the 100mg/kg BW treatment group. The findings from this study indicate that the ethanol extract of Fibraurea tinctoria Lour has an antidiabetic effect and the 100mg/kg BW dose was the most effective in lowering blood glucose levels.
Pengaruh Pemeriksaan Pajak, Penagihan Pajak Dan Self Assesment System Terhadap Penerimaan Pajak Dengan Kepatuhan Wajib Pajak Sebagai Variabel Moderasi
Authors: Wulandari Indah , Ngadiman Ngadiman
Published: February 2024

Penelitian yang berjudul Pengaruh Sistem Pemeriksaan Pajak, Penagihan Pajak, dan Self Assessment Terhadap Penerimaan Pajak dengan Kepatuhan Wajib Pajak sebagai Variabel Moderasi, dengan tujuan untuk mengetahui sistem pemeriksaan, pemungutan pajak, dan Self Assessment terhadap Penerimaan Pajak dengan Kepatuhan Wajib Pajak, Penelitian ini merupakan penelitian kausalitas, dengan menggunakan metode spss 26.0, populasi dalam penelitian ini adalah KPP Pratama Pondok Aren yang berlokasi di Pondok Aren Tangsel dengan sampel sesuai kriteria. Hasil penelitian ini berdasarkan hasil penelitian yang dilakukan pada KPP Pratama Pondok Aren periode 2019 – 2021 dapat disimpulkan bahwa Pemeriksaan Pajak mempunyai pengaruh positif signifikan terhadap Penerimaan Pajak. Persentase kontribusi pengaruh variabel independen Pemeriksaan Pajak terhadap Penerimaan Pajak sebesar 55,7%. Penagihan Pajak berpengaruh positif terhadap Penerimaan Pajak. Persentase kontribusi variabel independen Penagihan Pajak terhadap Penerimaan Pajak sebesar 53,8%. Self Assessment System tidak berpengaruh terhadap Penerimaan Pajak. Persentase kontribusi variabel independen Self Assessment System terhadap Penerimaan Pajak sebesar 5,8%. Kepatuhan Wajib Pajak mampu mempererat hubungan antara Pemeriksaan Pajak dan Penerimaan Pajak. Besarnya persentase kontribusi pengaruh variabel Kepatuhan Wajib Pajak dalam memoderasi pengaruh Pemeriksaan Pajak terhadap Penerimaan Pajak adalah sebesar 18,7%. Kepatuhan Wajib Pajak mampu mempererat hubungan Penagihan Pajak dan Penerimaan Pajak. Besarnya persentase kontribusi pengaruh variabel Kepatuhan Wajib Pajak dalam memoderasi pengaruh Penagihan Pajak terhadap Penerimaan Pajak adalah sebesar 30,7%. Kepatuhan Wajib Pajak merupakan variabel moderasi yang tidak mampu mempengaruhi hubungan Self Assessment System dengan Penerimaan Pajak
Employee Engagement, Work Motivation, Employee Creativity, Dan Job Satisfaction Sebagai Mediator Antara Reward Dengan Employee Performance
Authors: Wau Feliks Setia , Kustiawan Unggul
Published: February 2024

Penelitian ini bertujuan untuk mengetahui serta mengeksplor secara mendalam terkait pengaruh dari employee engagement, work motivation, employee creativity, dan job satisfaction sebagai mediator antara reward dengan employee performance pada Perguruan Tinggi Swasta di lingkungan DKI Jakarta. Hal ini merupakan pengembangan dari studi yang pernah dilakukan sebelumnya pada karyawan di Sukorejo, Pasuruan Indonesia. Pengumpulan data penelitian ini dibuat dengan metode survei dimana penyebaran kuesioner dilakukan secara online yang selanjutnya responden dipilih dengan menggunakan metode purpose sampling dengan menentukan sampel berdasarkan kriteria yaitu tenaga kependidikan pada Perguruan Tinggi Swasta di DKI Jakarta dengan status sebagai tenaga kependidikan minimal sudah 1 tahun bekerja. Untuk menguji hubungan antar variabel dalam membuktikan hipotesis, peneliti menggunakan analisis faktor serta permodelan persamaan struktural (SEM) Lisrel. Hasil menunjukkan bahwa variabel mediator employee engagement, work motivation, employee creativity, dan job satisfaction ternyata memiliki pengaruh positif secara langsung terhadap reward. Variabel tersebut dapat dijadikan sebagai salah satu kententuan atau kriteria dalam pemberian reward terhadap karyawan untuk memberikan kepuasan bagi perusahaan dalam mendukung program peningkatkan employee performance. Kontribusi dari penelitian ini diharapkan dapat memberikan suatu informasi pada tataran teori/keilmuan manajemen sumber daya manusia dan strategi yang bermanfaat bagi pengguna.
Perbandingan Kinerja Keuangan Bank Syariah Di Indonesia Dengan Bank Syariah Di Malaysia Periode 2022
Authors: Wiyani Meilisa Puji Tri , Sholahuddin Muhammad
Published: February 2024

Penelitian ini bertujuan untuk membandingkan kinerja keuangan perbankan syariah di Indonesia dan perbankan syariah di Malaysia periode 2022. Bank syariah mulai dikenal masyarakat luas dan berkembang pesat dalam dunia perbankan, salah satu alasannya ialah karena bank syariah menggunakan sistem bagi hasil bukan sistem bunga. Jika dilihat dari jumlah penduduk muslim di kedua negara tersebut, Indonesia memiliki populasi muslim yang lebih besar daripada Malaysia. Namun pada hasil penelitian tahun sebelumnya dan berdasarkan data IFDI 2020, Malaysia memliki kinerja keuangan yang lebih tinggi daripada Indonesia. Untuk mengevaluasi kinerja bank syariah dari kedua negara tersebut, penelitian ini menggunakan metode RGEC yaitu Risk-Profile yang diproksikan rasio FDR (Financing to Deposit Ratio), GCG (Good Corporate Governance), ROA (Return On Assets), dan CAR (Capital Adequacy Ratio). Menggunakan data sekunder dari masing-masing laporan tahunan bank syariah dikedua negara dengan populasi sampel yaitu purposive sampling. Hasil penelitian menunjukan bahwa terdapat perbedaan hasil yang signifikan pada ketiga rasio FDR, ROA, dan CAR. Sedangkan pada rasio GCG yaitu tata kelola perusahaan sendiri tidak terdapat perbedaan yang signifikan, namun bank syariah Malaysia mendapat peringkat penilaian self assessment sangat baik.