bluuebunny/crossref_metadata_2025 huggingface dataset:
КОМБІНАЦІЙНА ЗДАТНІСТЬ НОВИХ ЛІНІЙ РОЗЛУСНОЇ КУКУРУДЗИ (ZEA MAYS EVERTA STURT.)
Authors: КУПРІЧЕНКОВ Д.С.
Published: August 2023

Ефективність селекційної роботи з розлусною кукурудзою (Zea mays everta Sturt.) залежить від елітних ліній, на базі яких створюються конкурентоспроможні гібридів із високими технологічними показниками зерна. Об’ємне розширення зерна – важливий технологічний показник зерна розлусної кукурудзи. Метою дослідження було виявлення ліній розлусної кукурудзи з високою комбінаційною здатністю за ознаками «врожайність» і «об’ємне розширення зерна» та встановлення характеру успадкування цих ознак. Вихідним матеріалом для проведення досліджень були лінії розлусної кукурудзи, створені в лабораторії селекції кукурудзи харчового напряму використання ДУ Інститут зернових культур НААН України. Для визначення комбінаційної здатності 46 нових ліній розлусної кукурудзи були схрещені із 4 тестерами. Вивчення 170 трьохлінійних гібридів проходило на Синельниківській селекційно-дослідній станції протягом 2021–2022 рр. За результатами проведених досліджень було встановлено, що гібриди розлусної кукурудзи мали високі потенціали врожайності й об’ємного розширення зерна. Стабільно високі зна- чення ефектів загальної комбінаційної здатності (ЗКЗ) за врожайністю зерна були виявлені в лініях РС 19, РК 72, РП 36, РР 6, РР 7, ІКР 11-3, ІКР 11-9 та ІКР 15-2. Найбільша кількість ліній із високою ЗКЗ була отримана із гібрида Snow Puff Popcorn F1, а з низькою ЗКЗ – із сорту Japanese Hulless White Popcorn. Стабільно високі значення ефектів ЗКЗ за об’ємним розширенням зерна продемонстрували лінії РС 3, РК 7, РК 72, РП 72, ІКР 8-2, ІКР 36-3, ІКР 75-1. Гібриди Creme Puff Corn F1 і Pick and Pop Popcorn F1 були найкращим вихідним матеріалом для отримання ліній із високою ЗКЗ за об’ємним розширенням зерна, а найгіршим – сорт Red River Valley Popcorn. Стабільно високі ефекти ЗКЗ за обома ознаками були лише в лінії РК 72, що робить її незамінною для селекції конкурентних гібридів розлусної кукурудзи із високими технологічними показниками зерна. За результатами проведених досліджень було встановлено, що коефіцієнт успадковуваності H2 (в широкому розумінні) за ознакою врожайність дорівнював 0,88 і 0,81, а за об’ємним розширенням зерна – 0,89 і 0,91, тоді, як коефіцієнт успадковуваності h2 (у вузькому розумінні) – 0,40 і 0,43 та 0,35 і 0,37, відповідно. Отже, спадкові чинники мають переважаючий вплив на фенотипову мінливість досліджуваних ознак, водночас об’ємне розширення зерна контролюється неадитивною дією генів, тоді, як на врожайність впливають адитивні й неадитивні генні чинники.
АГРОХІМІЧНІ ВЛАСТИВОСТІ ҐРУНТУ ЗА ТРИВАЛОГО ЗАСТОСУВАННЯ МІНЕРАЛЬНИХ ДОБРИВ
Authors: ГОСПОДАРЕНКО Г.М. , ЛЮБИЧ В.В. , МАРТИНЮК А.Т.
Published: August 2023

Мета. Встановити агрохімічні властивостей чорнозему опідзоленого Правобережного Лісостепу за тривалого застосування мінеральних добрив. Методи. Польовий, лабораторний, вимірювальний, розрахунково-порівняльний, аналізування, статистичний. Результати. Дослідженнями встановлено, що інтенсивність тривалого застосування добрив позначилась на структурі ґрунтового вбирного комплексу чорнозему опідзоленого. Застосування мінеральних добрив суттєво підвищувало кислотність ґрунту, що пов’язано зі зменшенням насичення ҐВК карбонатами. Залежно від доз внесення мінеральних добрив показник рНКСl ґрунтового розчину знижувався на 0,3–0,4 од. За внесення фосфорних добрив на азотно-калійному тлі кислотність ґрунту не змінювалась. Поряд з обмінною кислотністю, застосування мінеральних добрив підвищувало гідролітичну кислотність ґрунту – до 3,76–3,84 смоль/кг залежно від варіанту удобрення. При цьому необхідно зазначити, що фосфорні добрива істотно не впливали на підвищення гідролітичної кислотності ґрунту. Вміст поживних речовин у ґрунті різних варіантів досліду визначався прямою дією добрив, які застосовували безпосередньо під культури сівозміни й післядією добрив, які вносили у сівозміні в попередні роки. Висновки. Тривале (11 років) застосування фосфорних, у поєднанні з іншими видами, добрив у дозі P60 у польовій сівозміні сприяє підвищенню вмісту рухомих сполук фосфору у ґрунті порівняно з вихідним значенням на 8%, а за внесення P30 – підтримувати його початковий вміст. Встановлено, що за різного агрохімічного навантаження проходять незначні зміни ємності ҐВК, але відбувається його структурна перебудова. У варіантах з внесенням фосфорних добрив не змінюються фізико-хімічні показники ґрунту. На ділянках без добрив вмісту рухомих сполук фосфору у ґрунті зменшився порівняно з вихідним значенням на 24%, а за внесення P60 на 1 га площі сівозміни – підвищився на 8%.
Newsvendor model with Brownian motion demand
Authors: Pandit Samuel
Published: August 2023

The newsvendor model is beneficial in managing inventories and determining the optimal ordering quantity. It assumes that the newsvendor knows the demand distribution and costs associated with it beforehand. However, due to demand uncertainty, predicting the demand before the selling period is a challenging task for the newsvendor. In this report, the uncertain demand is modeled to follow a geometric Brownian motion for its suitability for handling demand uncertainty. A numerical example is provided along with sensitivity analysis. This report illustrates that the parameters such as mean, customer loss-of-goodwill, and selling price per unit are inversely proportional to the expected total cost. On the contrary, the parameters such as holding cost, variance, and variable cost per unit are directly proportional to the expected total cost. This report shows that lower values of variance and higher values of mean contribute to the minimum values of the expected total cost. 
Improvisasi Peran Guru Pendidikan Agama Islam melalui Ekstrakurikuler Di Madrasah Ibtidaiyyah Nurussalam Mantingan Ngawi Jawa Timur
Authors: Samsirin Samsirin , Syarifah Syarifah , Barkah Siti Ane , Elfani Aisyah Rahma
Published: August 2023

Improvisasi pembelajaran sebagai suatu aktivitas yang dilakukan oleh seorang guru dalam pembelajaran dengan mengembangkan dan memperkaya persiapan pembelajaran yang dibuat dengan tujuan pembelajaran lebih baik dan berkualitas. Pendidikan merupakan suatu hal sangat harus diperhatikan oleh semua bangsa, karena pendidikan memiliki kaitan erat dengan kesuksesan generasi selanjutnya di masa yang akan mendatang. Peran seorang guru terutama dalam Pendidikan Agama Islam dirasa perlu dalam memajukan pendidikan Islam. Penelitian ini menggunakan metode deskriptif kualitatif dengan objek penelitian guru Pendidikan Agama Islam di Madrasah Ibtidaiyyah Nurussalam Mantingan, Ngawi Jawa Timur. Penelitian ini bertujuan untuk mendeskripsikan upaya yang dilakukan oleh guru untuk memajukan pendidikan Islam dengan hasil penelitian bahwasanya guru Pendidikan Agama Islam memiliki pengaruh dalam kemajuan pendidikan Islam. Kegiatan ekstrakulikuler yang diantaranya terdiri dari pidato, Tahfidz, pramuka, pencak silat, menjadi peran guru pai dalam menigktakan kualitas pemebelajaran.
MEDIA PEMBELAJARAN BERBASIS VIDEO DALAM MENINGKATKAN MOTIVASI BELAJAR PROTOZOA DAN MIKROALGA MAHASISWA PENDIDIKAN BIOLOGI PADA MATA KULIAH PROTISTA
Authors: Nuraisyah Siti , Farid Miftah , Rapsan Rapsan , Fransiska Anis Tri , Sari Prita Asminitya , Pratiwi Nadia , Ramayanti Ayu , Boleng Didimus Tanah , Rosrinda Eadvin , Turista Dora Dayu Rahma
Published: August 2023

Video media is a medium that provides information in the form of sound and visuals. Based on the results of observations obtained from biology education students who have received protist courses, the learning process is still centered on educators and textbooks or manuals, so students tend to be passive or lack interest and motivation to learn. Phenomena that are happening a lot at this time, for example when practicum activities take place only use manuals to find out how the activities will work, thus making some students not understand clearly the steps of the work being carried out. The purpose of this research is to increase student learning motivation in the Protist course. The application of videos can provide opportunities for students to collect information and make it easier to carry out learning activities. The subjects of this study were biology education students from class of 2019 and below with the condition that they had passed the protista course with a total of 55 respondents. The research instrument was conducted using qualitative and quantitative methods. The validity test results obtained had a significant value <0.05, namely 0.000 <0.05 and the reliability test had a Cronbach's Alpha value of 0.821 > 0.70. The conclusion obtained by video media is effective in helping the learning process.
Medición de la desigualdad educativa en los municipios del estado de Michoacán a través del coeficiente de Gini para 2020
Authors: Favila Tello Antonio , Huape Padilla Grecia Atenea
Published: August 2023

A través de los años, el estudio de la desigualdad educativa ha ocupado el interés de diferentes disciplinas sociales por su importancia para dar seguimiento a los avances educativos regionales y su utilidad como instrumento para valorar la acción pública al respecto. El grado de desigualdad educativa en una región da cuenta de la manera en la que la sociedad puede proveer de oportunidades educativas equitativas a la población y hacer efectivo el derecho a aprender de las niñas, niños y jóvenes. El presente estudio, con alcance descriptivo, tuvo por objetivo medir la desigualdad educativa, a través de la distribución de la escolaridad, para el caso de los municipios del estado de Michoacán, México, con datos para el año 2020. Para realizar lo anterior se utilizó una adaptación del coeficiente de Gini. Los resultados sugieren que las condiciones de mayor desigualdad se ubicaron en los municipios del sur del estado tales como Tumbiscatío, Tiquicheo, Carácuaro, Aguililla y Turicato. En contraste, las condiciones más igualitarias se encontraron en la capital del estado, Morelia, y los municipios de Tarímbaro, Briseñas, Nuevo Parangaricutiro, Purépero y Angangueo.
Pengembangan Media Pembelajaran Komik Strip Berbasis Flipbook Digital Pada Mata Pelajaran Projek Ilmu Pengetahuan Alam Dan Sosial
Authors: Elfina Eni , Waskito  , Darmi Resmi , Maksum Hasan
Published: August 2023

Kurangnya media pembelajaran mengakibatkan peserta didik kurang aktif dan antusias ketika proses pembelajaran berlangsung. Diperlukan adanya media pembelajaran yang dapat membantu dan memfasilitasi dalam membangkitkan minat belajar dan meningkatkan hasil belajar peserta didik di SMK. Penelitian ini bertujuan untuk mengetahui proses perancangan media pembelajaran komik strip berbasis flipbook, mengetahui tingkat kelayakan media. Model penelitian pengembangan yang digunakan yaitu model Instructional Development Institute (IDI) yang meliputi tahap define, develop dan evaluate. Media pembelajaran komik strip berbasis flipbook dirancang menggunakan software dan hardware. Hasil  penelitian  diperoleh dari produk  komik strip berbasis  flipbook pada  materi  projek IPAS bagi  kelas  X SMK. Berdasarkan hasil tersebut dapat disimpulkan bahwa media pembelajaran Berbasis flipbook pada materi projek IPAS bagi peserta didik Kelas X SMK dapat digunakan dalam pembelajaran projek IPAS, karena bisa meningkatkan motivasi, minat belajar serta bisa dilakukannya pembelajaran mandiri bagi siswa yang ingin mengulang pembelajaran di rumah.
Klasifikasi Penyakit Bawang Merah Menggunakan Naïve Bayes dan Convolutional Neural Network
Authors: Dian  , Purnawansyah  , Darwis Herdianti , Nurhayati Lilis
Published: August 2023

Bawang merah rentan terhadap serangan penyakit yang dapat mengganggu pertumbuhan dan mengakibatkan hasil panen yang tidak maksimal bahkan gagal panen, seperti bercak ungu dan moler. Penelitian ini bertujuan untuk mengklasifikasikan penyakit bawang merah dengan mengimplementasikan meetode naïve bayes (gaussian , bernoulli, dan multinomial) dan CNN pada citra bawang merah yang diekstraksi menggunakan fourier descriptor. Metode FD – CNN memperoleh tingkat accuracy 98% dalam mengklasifikasikan penyakut bawang merah, moler dan bercak ungu, sedangkan metode CNN tanpa menggunakan ekstraksi menghasilkan nilai accuracy sebesar 97%. Adapun pada metode naïve bayes, pengklasifikasian yang memiliki accuracy paling tinggi adalah metode gaussian naïve bayes  sebesar 95% sedangkan yang paling rendah yaitu metode bernoulli naïve bayes dengan tingkat accuracy sebesar 42%. Dengan demikian, dapat disimpulkan bahwa CNN, FD-CNN, dan FD-GNB efektif untuk meningkatkan performa klasifikasi pada citra daun bawang merah.
Performance Analysis of CT-Scan Covid-19 Classification Using VGG16-SVM
Authors: Buana Rifqi Genta , Abdulloh Ferian Fauzi
Published: August 2023

The world was shaken by the emergence of a deadly virus variant called Severe Acute Respiratory Distress Syndrome CoronaVirus 2 which causes COVID-19 disease. This phenomenon started at the end of 2019 which later became an outbreak that caused a deadly pandemic. A significant number of people lose their lives because of this outbreak. A fast and precise diagnosis is needed so that the patients can be treated immediately. This study is intended to overcome these problems by utilizing machine learning to classify lung CT-Scan images. This study propose to use the Convolutional Neural Network (CNN) based on Visual Geometry Group (VGG) 16 layers architecture and Support Vector Machine (SVM) as its classifier. The classification results of the proposed method achieve 89% and 96% accuracy on the two different datasets. This study results can help overcome problems related to the COVID-19 diagnosis and the lack of resources to classify images.
The world was shaken by the emergence of a deadly virus variant called Severe Acute Respiratory Distress Syndrome CoronaVirus 2 which causes COVID-19 disease. This phenomenon started at the end of 2019 which later became an outbreak that caused a deadly pandemic. A significant number of people lose their lives because of this outbreak. A fast and precise diagnosis is needed so that the patients can be treated immediately. This study is intended to overcome these problems by utilizing machine learning to classify lung CT-Scan images. This study propose to use the Convolutional Neural Network (CNN) based on Visual Geometry Group (VGG) 16 layers architecture and Support Vector Machine (SVM) as its classifier. The classification results of the proposed method achieve 89% and 96% accuracy on the two different datasets. This study results can help overcome problems related to the COVID-19 diagnosis and the lack of resources to classify images.
Usability Evaluation Of Social Security For Workers Applications In Public Institutions
Authors: Afrizon Asra , Hadi Putra Panca
Published: August 2023

Workforce social security application services are owned by the Indonesian government and held by the Social Security Administering Body on Employment. Initially, the application only provided social security programs, membership, and benefits information. In September 2021, the application was transformed by including transactions for claim redemption. User reviews of the application gave ratings of 1.5 and 4.4, respectively meanwhile complaints and requests for information in 2022 were the second highest, accounting for 65% and 5%, respectively. Through analysis of user reviews and complaints, it has been determined that users encounter multiple constraints when utilizing applications concerning accessibility, information, authentication, procedures, and comprehension of usage. The research method involves a quantitative approach using a user experience questionnaire and usability testing methods through task scenarios. Followed by a qualitative approach using a post-test interview to conduct deep dive into user problems and expectations. This study aims to evaluate the application's usability and provide recommendations for improvement. Based on the analysis from UEQ, the application get an average value positive, and the benchmark result is above average. In contrast, the novelty gets neutral, and the benchmark result is below average, reviewed as conventional, slow, less valuable, challenging to learn, and monotonous. The test task scenario described effectivity of application. Meanwhile, time-based efficiency is 0,04 goals/second, which can be interpreted as high speed. Task scenario finding explains 30 problems in which three tasks are prioritized. Post-test interviews explained user need for frequently accessed features, difficulty to use, and usage limitations. The recommendations aimed to adjust the interface and functionality to meet user needs, providing a satisfying experience and shortening the self-service process.
Development of Android-Based Learning Media in Information Communication Technology (ICT) at Senior High School
Authors: Indah Indah Rahmatika Sari , Effendi Hansi , Lapisa Remon , Wulansari Rizky Ema
Published: August 2023

Android-based learning media is one of the media that is easy to use by teachers and students in achieving learning objectives.  This study aims to produce valid, practical, and effective learning media used for learning. The method used is Research and Development (R&D) with a 4-D development model (four D models).  This study used an instrument in the form of a questionnaire. The questionnaires were divided into validation questionnaires, practicality, and effectiveness questionnaires. For data analysis, researchers used Aiken's formula and Gain Score.  The validation sheet is filled out by 4 validators consisting of 2 material validators and 2 media validator. The practicality sheet is filled out by 30 students and 2 teacher.  For effectiveness data used questions filled out by students. The questionnaire data obtained a validity level of 0.95 which indicates that the developed media is valid.  For practicality, the result is 90% with the very practical category.  The effectiveness of the developed media is seen from the value of students.  After using the media, 100% of students had scores above the KKM, while from the gain score test, they got a value of 0.75 which means that the learning media developed can be said to be effective. Based on these data it can be concluded that android-based learning media in Information and Communication Technology (ICT) subjects is valid, practical, and effective for use as learning media.
Sistem Prediksi Kelulusan Santri Tahfidz Qur’an Menggunakan Algoritma C4.5
Authors: Sriani  , Juraidah Juraidah
Published: August 2023

Yayasan Tahfidz Qur’an Umul Mukminin Aisyah merupakan lembaga pendidikan penghafal Al-Qur’an yang setiap tahun kuota santri semakin bertambah. Namun, tidaklsemua santri dapat lulus tepat waktu sesuai masaabelajar yang ditempuhhsehingga mengakibatkannpenumpukkan santri yang tidakllulus sesuai masapperiodelkelulusanya. Penentuan kelulusan santri berdasarkan beberapa kriteria yang harus dilalui oleh santri selama menempuh pembelajaran dilYayasan Tahfidz Qur’an. Oleh karena itu, perlu dilakukan penelitian menggunakannteknik klasifikasi yanggdapat mengolahhdata dalam jumlahhbesar untuk menemukanppola yang terjadilpada dataasantri. Pengolahanndata tersebut digunakan untuk memprediksikkelas yang belumddiketahui yaitu prediksikkelulusan santri. Teknikkklasifikasi yanggdigunakan adalah decisionttreeedengan penerapanaalgoritmaaC4.5. Inputannyang digunakannberupa data santri yanggmeliputi dari prestasi, kedisiplinan, hapalan dan lafadz. Data santri yang digunakan adalah data sampelttraining yang sudah lulus pada tahun 2019 dengan jumlah data 170. Dimana berdasarkan hasil pengolahan, didapati 114 data santri lulus dan 56 tidak lulus.
Klasifikasi Tinggi Badan Menggunakan Metode Mask R-CNN
Authors: Permana Sanusi Amadea , Fariza Arna , Setiawardhana
Published: August 2023

Tinggi badan adalah parameter penting saat memasuki sebuah wahana. Penggunaan alat keselamatan saat bermain wahana permainan tidak akan maksimal jika wisatawan tidak memiliki tinggi badan yang sesuai dengan kriteria untuk memasuki wahana tersebut. Dalam penerapannya, seleksi wisatawan yang diperbolehkan masuk ke dalam wahana permainan masih menggunakan pengukuran tinggi badan secara manual. Penelitian ini bertujuan untuk mengurangi resiko terjadinya kecelakaan pada kendaraan dengan mengklasifikasikan dan mengimplementasikan sistem otomasi menggunakan pendekatan deep learning. Penggunaan deep learning yang berkembang saat ini dapat digunakan untuk mengklasifikasikan pengunjung. Penelitian ini mengusulkan proses klasifikasi tinggi badan menggunakan metode Mask R-CNN yang dapat digunakan untuk melakukan klasifikasi lebih dari satu orang, sehingga mempercepat antrean wisatawan pada wahana permainan. Hasil pengujian menunjukkan bahwa model Mask R-CNN yang dibangun berhasil mengklasifikasikan objek dengan memberikan bounding box, masking, dan label yang sesuai dengan objek. Membangun model Mask R-CNN sangat dipengaruhi oleh variatif gambar pada dataset dan proses anotasi gambar di dalam dataset. Evaluasi model menunjukkan hasil perhitungan mAP yang didapatkan sebesar 71%. Penelitian ini telah memenuhi tujuan utama dalam penelitian karena model Mask R-CNN berhasil melakukan klasifikasi yang sesuai.
Decision Support System for Determining the Best Online Learning Application Using the Weighted Product Method (WPM)
Authors: Yeka Hendriyani  , Mariani  , Rahmatika Hayati , Akbar Ilahi  , Hardeyenti Dessy
Published: August 2023

This article discusses the use of the Weighted Product (WP) Method in a Decision Support System to determine the best online learning application. The goal is to help users choose a learning app that suits their needs and preferences. Relevant criteria, such as user interface, learning content, interactive features, difficulty level, and subscription price, are identified and assigned relative weights. This study uses data from various online learning apps to train the WP model and rank the apps based on the highest scores. The experimental results show that the WP method successfully identifies the best online learning apps with high accuracy, allowing users to have an effective and efficient learning experience according to their individual goals. Thus, this SDM can be an effective guide for users in making informed decisions to meet their education and learning needs
Evaluation of Countinance Stake on the Implementation of Project Based Learning in the Automotive Engineering Department
Authors: Fajar Fajar Riyaddi , Waskita  , Ambiyar  , Lapisa Remon
Published: August 2023

Evaluation as an action to find out or an attempt to see the extent to which the goals set have been achieved. In other words, the goal is a tool to determine the success of the learning process that occurs between educators and students. The purpose of this study was to look at the results of the evaluation of project-based learning in productive subjects for students majoring in automotive at the 1 Pantai Cermin Vocational High School. This type of research is evaluative research using a qualitative approach. The evaluation method used is the STAKE method, which evaluates plans, processes and results. The findings of this study, namely, that project-based learning has been implemented for students in the automotive major at Pantai Cermin Vocational High School 1 found that the implementation of project-based learning still has deficiencies in terms of preparation and results. Viewed from the preparation aspect, it was found that the project delivery from the teacher was unclear and not specific, while from the results aspect, the projects undertaken were still limited to video tutorials that had not been published. The conclusion from this research is that project-based learning still needs careful planning to match the expected results or objectives.
Pengembangan User Experience Kesehatan Mental untuk Peningkatan Bisnis Perusahaan Start Up
Authors: Handoko Mahardika Maulana Al Mahdi , Kusumasari Tien Fabrianti , Suakanto Sinung
Published: August 2023

Teknologi memainkan peran penting dalam bidang kesehatan mental, terutama dalam membantu individu mengelola stres dan gangguan mental. Startup kesehatan mental merupakan jenis usaha yang memanfaatkan teknologi dan pendekatan inovatif untuk mengatasi masalah kesehatan mental dan meningkatkan akses ke penanganan kesehatan mental. Tujuan penelitian ini adalah untuk melakukan pengembangan User Experience pada Kesehatan Mental untuk meningkatkan kepuasan pengguna sehingga dapat meningkatan bisnis Perusahaan Startup. Hasil dari pengumpulan data menunjukkan bahwa kebutuhan pengguna adalah Platform Kesehatan Mental Online yang dengan harga yang murah, durasi yang cukup, dan memiliki fleksibilitas waktu dimana pengguna dapat menggunakan platform sebagai tempat bercerita. . Hasil pengembangan diukur dengan pengujian System Usability Testing dengan 10 responden mendapatkan hasil skor 73,5 pada pengujian Usability Testing menandakan bahwa hasil pengembangan User Experience berada pada kategori Acceptable dengan Grade C.
Immunochemotherapy plus lenalidomide for high-risk mantle cell lymphoma with measurable residual disease evaluation
Authors: Epstein-Peterson Zachary D. , Drill Esther , Aypar Umut , Batlevi Connie Lee , Caron Philip , Dogan Ahmet , Drullinsky Pamela , Gerecitano John , Hamlin Paul A. , Ho Caleb , Jacob Allison , Joseph Ashlee , Laraque Leana , Matasar Matthew J. , Moskowitz Alison J. , Moskowitz Craig H. , Mullins Chelsea , Owens Colette , Salles Gilles , Schöder Heiko , Straus David J. , Younes Anas , Zelenetz Andrew D. , Kumar Anita
Published: August 2023

Chemoimmunotherapy followed by consolidative high-dose therapy with autologous stem cell rescue was a standard upfront treatment for fit patients with mantle cell lymphoma (MCL) in first remission; however, treatment paradigms are evolving in the era of novel therapies. Lenalidomide is an immunomodulatory agent with known efficacy in treating MCL. We conducted a single-center, investigator-initiated, phase II study of immunochemotherapy incorporating lenalidomide, without autologous stem cell transplant consolidation, enriching for patients with high-risk MCL (NCT02633137). Patients received four cycles of lenalidomide-R-CHOP, two cycles of R-HiDAC, and six cycles of R-lenalidomide. The primary endpoint was rate of 3-year progression-free survival. We measured MRD using an NGS-based assay after each phase of treatment and at 6 months following end-of-treatment. We enrolled 49 patients of which 47 were response evaluable. By intent-to-treat, rates of overall and complete response were equivalent at 88% (43/49), one patient with stable disease, and two patients had disease progression during study; 3-year progression-free survival was 63% (primary endpoint not met) and differed by TP53 status (78% WT versus 38% ALT, P = 0.043). MRD status was prognostic and predicted long-term outcomes following R-HiDAC and at 6 months following end-of-treatment. In a high-dose therapy-sparing, intensive approach, we achieved favorable outcomes in TP53-wildtype MCL, including high-risk cases. We confirmed that sequential MRD assessment is a powerful prognostic tool in patients with MCL.
Which is the best treatment strategy before autologous peripheral blood stem cell transplantation in POEMS syndrome?
Authors: Autore Francesco , Bramanti Stefania , Lessi Federica , Innocenti Idanna , Galli Eugenio , Rocchi Serena , Ribolla Rossella , Derudas Daniele , Oliva Stefania , Stefanoni Paola , Marcatti Magda , Schenone Angelo , La Nasa Giorgio , Crippa Claudia , Zamagni Elena , Riva Marcello , Mazza Rita , Mannina Daniele , Sica Simona , Bacigalupo Andrea , Laurenti Luca
Published: August 2023

Autologous peripheral blood stem cell transplantation (aPBSCT) provides optimal outcomes in POEMS syndrome but the definition of the best treatment before aPBSCT remains to be defined, because of the disease rarity and the heterogeneity of published case series.
We collected clinical and laboratory data of patients with POEMS syndrome undergoing aPBSCT from 1998 to 2020 in 10 Italian centres. The primary endpoint of the study was to evaluate the impact of prior therapies and mobilizing regimen on outcome.
We divided patients in three groups: patients who did not receive any treatment before transplant (15 patients, group A: front-line), pre-treated patients with other agents (14 patients, group B) and patients treated with cyclophosphamide as mobilizing regimen (16 patients, group C). The three groups did not show differences in terms of demographic and clinical characteristics.
All 45 patients underwent aPBSCT after high dose melphalan conditioning regimen, with a median follow-up of 77 months (37-169 months). The responses were not statistically different between the 3 groups (p 0.38). PFS and OS rates at 6 years were 65% (49-85) and 92% (84-100), respectively and did not differ in the 3 groups. The cumulative incidence of transplant related mortality and relapse was respectively 4% and 36%.
In conclusion, in a relatively large number of patients with POEMS syndrome, undergoing an autologous transplant, pre-treatment and disease status at transplant did not appear to have an impact on major transplant outcomes.
Colletotrichum truncatum, an endophytic fungus derived from Musa acuminata (AAA group): antifungal activity against Aspergillus isolated from COVID-19 patients and indole-3-acetic acid (IAA) production
Authors: Yansombat Jiraporn , Samosornsuk Seksun , Khattiyawech Chollanant , Hematulin Panarat , Pharamat Thirawatthana , Kabir SM Lutful , Samosornsuk Worada
Published: August 2023

Fungal endophyte is a fungal that lives in plant organism as mutualism association. The role of fungal endophyte is a growth promoter or/and microbial pathogen inhibitor. This study investigated antifungal activity of Colletotrichum truncatum E10, an endophytic fungus derived from Musa acuminata (AAA group), against 7 isolates of Aspergillus obtained from lower respiratory samples of COVID-19 patients. In addition, IAA production of this strain was also observed. All isolates of Aspergillus were identified using MALDI-TOF MS. The fungal endophyte, C. truncatum E10, was screened for IAA induction with and without 0.1, 2 and 8 mg/mL of L-tryptophan based on colorimetric method using Salkowski reagent which produced pinkish to reddish solution indicating the presence of IAA. Antagonist activity was based on dual culture assay measured in colony growth inhibition (CGI). C. truncatum E10 produced the highest IAA concentration of 112.81±0.12 µg/mL when 8 mg/mL of L-tryptophan added.  The strong antagonist activities were shown by C. truncatum E10 against 5 Aspergillus isolates including 2 A. fumigatus: sp442/6 (CGI=57.83±5.11%) and sp269/11 (CGI=53.01±8.52%), 1 A. niger sp26/7 (CGI=57.83±15.33%) and 2 A. flavus: sp26/7 (CGI=56.63±13.63%) and sp36/7 (CGI=57.23±0.85%), whereas the colony growth inhibition (CGI) of other 2 isolates including A. fumigatus sp567/6 and A. flavus sp269/11 were less than 50%. In this study, C. truncatum E10 produced substances that inhibited human fungal pathogen including A. fumigatus, A. flavus and A. niger. Moreover, it can produce IAA activity. Further investigations are being conducted to expand the plant growth promotion effects and determine IAA biosynthesis pathway. For antifungal activity, the bioactive metabolites produced by this endophytic fungal isolate should be characterized to specify the effective compounds.
Asian Australas. J. Biosci. Biotechnol. 2023, 8 (2), 23-29
Degradation of selected organophosphorus pesticide residues and their pre harvest interval determination in hyacinth bean grown commercially in Bangladesh
Authors: Khanom Rozina , Islam Md Safiqul , Rahman S M Mizanur , Prodhan Mohammad Dalower Hossain
Published: August 2023

The consumers are very much concerned about food safety. To ensure safe food for the consumers, it is essential to follow the pre harvest interval (PHI) of pesticides. Therefore, in order to ascertain the pre-harvest interval of fenitrothion and diazinon in hyacinth bean in the environmental conditions of Bangladesh, this study was started. The chosen organophosphorus insecticides (fenitrothion and diazinon) were sprayed with the recommended dose (1.5 ml/L of water) in a field trial at the Entomology Division of BARI, Gazipur. At 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, and 12 days after spray (DAS), samples were taken. The Gas chromatography (GC) with a Flame Thermionic Detector (FTD) was used to quantify the residues after the samples were prepared using a modified Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) extraction method. Fenitrothion residue was found up to 8 DAS, and at 7 DAS (0.018 mg/Kg), the level of residue was above the MRL. At 8 DAS, the fenitrothion residue was 0.007 mg/kg, which was below MRL. Pre-harvest interval (PHI) for fenitrothion was determined at 8 DAS, and no residue was found after 9 DAS. Diazinon residue was found up to 9 DAS, with the level of residue above the MRL at 8 DAS (0.016 mg/Kg). At 9 DAS, the diazinon residue was 0.007 mg/kg, which was below MRL. Pre-harvest interval (PHI) was determined for diazinon at 9 DAS, and as of 10 DAS, no residue was found.
Asian Australas. J. Biosci. Biotechnol. 2023, 8 (2), 30-37
KONSERVASI KAWASAN HUTAN DI LAMANDAU DENGAN KONSEP BIOREMIADIASI DAN ADAT DAYAK KAHARINGAN (Tajahan, Kaleka, Sapan Pahewan, dan Pukung Himba)
Authors: Hujjatusnaini Noor
Published: August 2023

Kawasan hutan di Lamandau mengalami beberapa kerusakan, meliputi flora dan fauna, maupun sistem perairannya. Kerusakan tersebut disebabkan oleh beberapa faktor diantaranya perambahan kawasan hutan sebagai lahan industri kelapa sawit dan sistem limbah cair industri kelapa sawit yang bermuara di sungai yangÂ  mengakibatkan Â penurunan Â kualitas Â air, Â sedimentasi Â di Â perairan Â sebagai akibat dari tambang pasir dan tambang emas di sepanjang sungai yang mengakibatkan pendangkalan muara sungai dan pencemaran sungai berupa kadar merkuri yang diambang batas. Untuk dapat mengatasi permasalahan agar kerusakan tidak berlanjut, upaya yang dapat dilakukan adalah dengan melakukan konservasi. Beberapa penelitian untuk mengatasi kerusakan sistem perairan dilakukanÂ Â  denganÂ  Â konservasiÂ Â  menggunakanÂ  Â konsepÂ Â  bioremidiasi.Â  Â Untuk kerusakan kawasan hutan meliputi pelestarian flora dan fauna di Lamandau, masyarakat khas suku Dayak mempunyai Â upaya konservasi dengan cara Tajahan, Kaleka, Sapan Pahewan dan Pukung Himba.
Pelatihan dan Pendampingan Praktikum IPA Kontekstual Bagi Guru- guru setingkat SD di MIN SasaKota Ternate
Authors: Haerullah Ade , Suparman Suparman
Published: August 2023

Kegiatan Pengabdian mandiri dosen untuk guru setingkat Sekolah Dasar di Kota Ternate khususnya guru-guru MIN Sasa Ternate dan MI Al-Marif Ternate. Dari hasil observasi, analisis situasi, dan justifikasi masalah bersama kedua mitra maka masalah prioritas yang penting untuk dicarikan solusi ialah proses pembelajaran yang secara umum masih bersifat tekstual. Salah satu penyebabnya ialah kemampuan guru dalam melaksanakan praktikum masih kurang. Sehingga tawaran solusi konkrit berdasarkan hal tersebut ialah pelatihan dan pendampingan praktikum IPA kontekstual bagi guru-guru yang dilanjutkan dengan pendampingan pelaksanaan praktikum. Luaran pengabdian ini ialah keterampilan melakukan praktikum IPA kontekstual oleh guru, dan panduan praktikum IPA untuk siswa SD materi air, fotosintesis, makanan, dan listrik.Metode pengabdian dilakukan dua tahap, yakni pelatihan praktikum dan pendampingan praktikum.Hasil kegiatan yakni 20 orang guru mengikuti pelatihan praktikum IPA kontekstual dengan materi: sifat air, fotosintesis, listrik, dan berat badan. Sebanyak 95% peserta merasakan mendapat pengalaman baru setelah mengikuti pelatihan, dan secara keseluruhan guru mengungkapkan akan menerapakan praktikum yang telah dilatih.
UJI KANDUNGAN SENYAWA DAN ORGANOLEPTIK BUAH MANGROVE UNTUK DIJADIKAN SIRUP DAN MINUMAN SERBUK MANGROVE
Authors: Tian Ade , Tolangara Abdulrasyid , Suparman Suparman
Published: August 2023

Pengelolaan mangrove sangat variatif dan menghasilkan banyak produk. Dua potensi pangan yang dapat dikelola dari mangrove adalah sirup dan minuman serbuk buah mangrove. Sirup dapat dihasilkan dari jenis Sonneratia alba Â yang diambil ekstraknya dan dikombinasi dengan gula, frambosen dan pewarna makanan. Serbuk mangrove dibuat dari buah mangrove jenis Rhizopora apiculata dengan cara dijemur, sangrai lalu digiling sampai halus dari bagian epikotil mangrove. Tujuan penelitian ini untuk mengetahui kandungan senyawa dan uji organoleptik pada kedua buah mangrove. Metode yang digunakan ialah ekstrasi SOXHLET dan APHA untuk mengetahui kandungan karbohidrat, protein, lemak dan senyawa sianida (HCN) serta uji organoleptik yang meliputi: rasa, tekstur, aroma dan warna. Hasil penelitian menunjukkan bahwa kandungan gizi yang dimiliki yaitu berupa lemak sebesar 0,26 %, protein sebesar 0,3 % dan karbohidrat sebesar 1,6 %. Sonneratia alba Â dan Rhizopora apiculata memiliki kandungan HCN sebesar 16,20 ppm dan 12,70 ppm sehingga aman untuk dikonsumsi dan dapat diolah menjadi olahan pangan lainnya. Pengujian organoleptik pada sirup dan minuman serbuk buah mangrove dari tiap-tiap pengujian kategori yang paling banyak dipilih suka selanjutnya sangat suka, agak kental, dan agak halus setelah itu agak suka, sangat kental, dan sangat halus adapun kategori yang lain tidak ada yang memilih.Â
Pengaruh Model Pembelajaran Inquiry Training Terhadap Hasil Belajar Siswa Kelas X Pada Materi Larutan Elektrolit Dan Nonelektrolit Di SMA Negeri 3 Kepulauan Sula
Authors: Umasangadji Megawati , Umar Sudir , Limatahu Nur Asbirayani , Muin Fadlan
Published: August 2023

AbstrakPenelitian ini dilakukan untuk mengetahui Pengaruh Model Pembelajaran Inquiry Training Terhadap Hasil Belajar Siswa Kelas X Pada Materi Larutan Elektrolit Dan Nonelektrolit Di SMA Negeri 3 Kepulauan Sula. Jenis penelitian yang digunakan adalah penelitian eksperimen dengan desain penelitian yaitu One Group Pretest Posttest Desain. Populasi dalam penelitian adalah seluruh siswa siswi kelas X SMA Negeri 3 Kepulauan Sula yang berjumlah 25 orang dengan teknik pengambilan sampel yaitu sampling jenuh. Instrumen yang digunakan dalam penelitian ini yaitu instrumen tes berupa soal essay sebanyak 10 nomor. Data yang diperoleh selanjutnya dianalisis menggunakan SPSS 29.0. Hasil uji hipotesis dalam penelitian ini diperoleh dari uji Paired Sample T Test, thitung  ttabel (12,972  1,710) maka Ha diterima dan HO ditolak. Sehingga model pembelajaran Inquiry Training berpengaruh terhadap hasil belajar siswa, dengan besar pengaruh yang diperoleh dari uji nilai gain sebesar 0,44 dengan kategori sedang. Kata Kunci: Inquiry Training, Hasil belajar, Larutan Elektrolit dan NonelektrolitAbstractThis research was conducted to determine the effect of the Inquiry Training Learning Model on the Learning Outcomes of Class X Students in the Material of Electrolyte and Non-electrolyte Solutions at SMA Negeri 3 Kepulauan Sula. The type of research used is experimental research with a research design that is One Group Pretest Posttest Design. The population in the study were all 25 students of class X SMA Negeri 3 Sula Archipelago, using a sampling technique, namely saturated sampling. The instrument used in this study was a test instrument in the from of 10 numbers of essay questions. The data obtained were then analyzed using SPSS 29.0. The results of  hypothesis testing in this study were obtained from the Paired Sample T Test, tcount  ttable (12.972  1.710) then Ha was accepted and Ho was rejected. So that the Inquiry Training learning model has an effect on student learning outcomes, with a large influence obtained from the gain value test of 0.44 in the medium category. Keywords:Inquiry training, learning outcomes, electrolyte and nonelectrolyte
Determining the Value of the Viscosity Coefficient of Pertalite Gas Stations and Retail Filling Stations Using the Logger Pro Application
Authors: Sinensis Arini Rosa , Firdaus Thoha , Effendi Effendi , Widayanti Widayanti , Verawati Defi
Published: August 2023

This study aims to determine the absolute viscosity value of pertalite fuel sold at gas stations and retail. The method used is an experiment with video analysis assisted by Logger Pro software. The number of retail pertalite samples tested consisted of 5 samples taken from different places. The research step is to analyze the video recorded on the motion of a falling object, namely an iron ball (Gotri) into the fluid (pertalite fuel) with logger pro software then track the video recording and obtain terminal time and speed data. From the results of the terminal velocity then it is calculated to the absolute viscosity equation. The results of the test showed that there was no significant difference between the viscosity of pertalite sold by gas stations and those sold at retail. This is evidenced by the average viscosity coefficient value of Pertalite gas stations of 0.4074 (Ns/mÂ²) while the viscosity of retail pertalite is 0.4019 (Ns/m2). These results conclude that the pertalite sold retail in East Ogan Komering Ulu area is still maintains the quality of pertalite from gas stations so that it is safe for vehicle engine performance.
Osmotik Word Level Teredo navalis Linnaeus 1758 in the Mangrove Root Habitat in East Halmahera, Indonesia
Authors: Sinyo Yumima , Suparman Suparman , Daud Asmar Hi , Robo Tamrin
Published: August 2023

This study aims to analyze the osmotic work level and pattern of osmoregulation at mollusc Teredo navalis Linnaeus 1758 in mangrove root habitats from different salinities. Case study was performed with the purposive sampling method. The research data were analyzed descriptively and quantitatively. The sampling technique is based on tidal conditions of seawater. Two locations was designated, namely station I and II in the north and the south respectively. Teredo navalis samples were taken from 2 types of mangrove roots. Analysis of the level of osmotic work using Automatic Micro Osmometer Roebling Type 13/13 DR. Salinity was measured using a refractometer. The results showed that the osmotic level of Teredo navalis in the root habitat of Rhizophora sp. and Avicennia sp. at high and low tide conditions varied, specifically 523 mOsm/l H2O, 123 mOsm/l H2O, and 32 mOsm/l H2O. This varying level of osmotic action results in three patterns of osmoregulation, viz. hyperosmotic, hypoosmotic, and isosmotic. The highest salinity was found in Avicennia sp. mangrove at station II and the lowest in Rhizophora sp. at low tide at station II, with the value was 31â€° and 10â€° respectively. Differences in salinity determine the osmoregulation pattern of Teredo navalis L in different habitats.
Analysis of Trip Attraction Models in Morotai CBD (Central Business District)
Authors: Darwis Fitro , Djafar Anggriyawan , Mulya Elfira Resti
Published: August 2023

The development of an area in land use can increase along with the increase in population in Morotai Island Regency, including the Morotai CBD area. In terms of urban transportation systems, generation and attraction have an important role in defining the development of a city, region, or area. The purpose of this research is to analyze of trip attraction modeling in the CBD area of Morotai. The concept of trip attraction modeling is analyzed using regression analysis, with various independent variables. The modeling analysis was carried out with the help of SPSS software using Stepwise multiple linear analysis methods. The results of the study show that the factors that influence the attraction of vehicle in the Morotai CBD area are : the number of visitors (X4), the ratio of visitors against the building area (X10), the ratio of employees against the number of rooms (X13), the number of rooms(X5), the ratio of employees against the building area (X11), as well as the ratio of employees against the number of rooms(X12). And from the results of linear regression analysis, the best transport attraction model was found to be Y 1 = 86.790 + 0.422X 4 â€“ 558.735X 10 + 1.949X 13 Â for the motorcycle (SM) attraction model and Y 2 = 12.183 + 0.091X 5 â€“ 26.265X 11 + 0.292X 12Â  for the light vehicle (KR) model.
Look Up (Again) The Apophis Asteroid: Simulating and Visualizing Orbit
Authors: Asmoro Cahyo Puji , Utama Judhistira Aria , Sondana Deni Karsa
Published: August 2023

The asteroid Apophis, first discovered in 2004 by American astronomers, is known to have a dangerous potential for planet Earth. Many early studies predict that in 2029 it will experience a close encounter and have a possible collision with the Earth at the next close encounter due to keyhole gravity. This research will explain how to carry out an orbit simulation using an orbit integrator to review this possibility and the evolution of the Apophis asteroid orbit over the next 500 years. The results of this study are expected to provide an understanding of simulating asteroid orbit from its orbital parameters and to build awareness of the threat of danger from small solar system objects such as asteroids, comets, and meteoroids.
Digital Game to Support the Effectiveness of Using Interactive e-Module on Vibration and Waves Concept (IeMVWC)
Authors: Saprudin Saprudin , Januarsih Melwenti Sikti , Rahman Nurdin Abdul , Rizal Rahmat
Published: August 2023

Digital games have the potential to increase the effectiveness of using interactive e-modules. This development research aims to produce an interactive e-module on vibration and waves concept (IeMVWC) assisted by digital games, as well as investigate the impact of its use on student learning achievement. This development research follows the ADDIE stages (Analyze, Design, Develop, Implement, and Evaluate). The data collected in this study includes product validation data, learning achievement data, and student response data collected through validation sheets, multiple-choice questions, and questionnaires. The IeMVWC product assisted by digital games produced is declared very feasible for use in learning and effective in improving student learning achievement in vibration and wave learning.
Refah Devletine Etkileri Üzerinden Göçmen Algısının İncelenmesi
Authors: KARAPINAR KOCAĞ Esra
Published: August 2023

Göçmenlerin ev sahibi ülkedeki etkileri oldukça sık tartışılan, siyasetçiler ve alanda araştırma yapanlar dışında halkın da dâhil olduğu geniş çevrede etki bulan bir konu olmaya devam etmektedir. Ev sahibi ülkedeki yerlilerin göçmenler hakkındaki düşünceleri ülkede entegrasyonun sağlanması açısından başlıca koşullardandır. Bu bağlamda söz konusu çalışmada yerlilerin göçmenlerin refah sistemi üzerindeki etkisi hakkındaki düşünceleri incelenmiştir. Dünya Değerler Araştırması (World Value Survey-WVS)’nın yedinci dalgası (2017-2020) ve Portekiz örneği kullanılarak bireylerin refah sistemi üzerinden göçe bakışları incelenmiştir. Daha açık bir ifadeyle, yerliler göçmenleri bir yük olarak görüyorlar mı yoksa yük olmadıklarını mı düşünüyorlar sorusu kullanılarak, bu düşüncelerini etkileyen unsurlar sıralı probit model yardımıyla açıklanmıştır. Elde edilen bulgular bireylerin eğitim düzeyinin bu düşünceyi şekillendirmekte önemli bir değişken olduğunu göstermektedir. Bunun dışında, bireylerin medeni halinin ve mutluluk düzeyinin de sınırlı da olsa eki ettiği gözlenmiştir.
Esnekliğin Acil ve Beklenmedik Durum Adaptasyonu Üzerindeki Etkisi Korkuya Rağmen Israrın Düzenleyici Rolü
Authors: GÜLBAHAR Yasemin , ÜZÜM Burcu
Published: August 2023

Bu çalışma, esneklik ile acil ve beklenmedik durum adaptasyonunu arasındaki ilişkiye odaklanarak bu ilişkide korkuya rağmen ısrarın düzenleyici rolünü ortaya koymayı amaçlamıştır. Nevşehir ilinde faaliyette bulunan seyahat acentaları yöneticisi 308 kişiden elde edilen verilerin hiyerarşik regresyon ile analizi sonucunda, esnekliğin acil ve beklenmedik durum adaptasyonu üzerindeki pozitif etkisi belirlenerek bu ilişkide korkuya rağmen ısrarın düzenleyici etkisi olduğu ortaya konmuştur. Kaynakların Korunması Teorisi (KKT) ve Planlanmış Davranış Teorisi’nden (PDT) yararlanan bu çalışma, hem esnekliğin hem de korkuya rağmen ısrarın önemli etkilerini doğrulamaktadır. Araştırma bulguları örgütsel alanda faaliyet gösteren yönetici ve girişimcilerin çevrenin oluşturduğu dengesiz ve belirsiz durumlarda karşılaşılabilecek acil ve öngörülemeyen durumlar karşısında pozitif kişilik özelliklerinden faydalandıklarını göstermektedir. Esneklik ve ısrarın bu zorlukları aşmaya, bunalım durumlarından hızla geri dönmeye, zor koşullarda dahi yönetici ve girişimcilerin devam etmelerine yardımcı olarak girişim başarısına katkıda bulunduğu ortaya konmuştur.