bluuebunny/crossref_metadata_2025 huggingface dataset:
HUBUNGAN ASUPAN ENERGI, PROPORSI MAKAN MALAM, DURASI TIDUR, DAN AKTIVITAS FISIK DENGAN KEJADIAN GIZI LEBIH PADA GURU DI PERGURUAN MUHAMMADIYAH RAWAMANGUN
Authors: Qorirah Salsabila , Rahayu Leni Sri
Published: June 2024

The problem that will be studied in this study is about the relationship between energy intake, dinner proportion, sleep duration, and physical activity with the incidence of excess nutrition in Muhammadiyah Rawamangun College. This research uses a type of quantitative research with a cross-sectional design. The population in this study were teachers at SD 24, SMP 31, and SMA 11 Muhammadiyah Rawamangun. Using a total sampling technique with a total sample of 61. Data collection was collected directly, namely in the form of anthropometric measurements, 2x24-hour food recall interviews, filling out sleep duration and physical activity questionnaires. Univariate data will be presented in tabular form. Bivariate data analysis technique with chi-square. Based on the results of the research, it was found that there was a relationship between energy intake (P=0.000), sleep duration (P=0.002), and physical activity (P= 0.000) with the incidence of overnutrition and conversely, there was no relationship between the proportion of dinner energy (P=0.378) with the incidence of overweight. In conclusion, energy intake, sleep duration, and physical activity are related to the incidence of overnutrition, but there is no relationship between the proportion of dinner and the incidence of being overweight among teachers at the Rawamangun Muhammadiyah College.
PENGARUH SUBSTITUSI TELUR KEONG MAS (Pomacea canaliculata L.) TERHADAP KADAR PROTEIN, KALSIUM DAN KALIUM PADA KUE BOLU
Authors: Kurniati Wenny Dwi , Panjaitan Petni Nauli Br. , Hardiansyah Angga
Published: June 2024

So far, golden snail eggs have not been widely used as a processed food ingredient. Meanwhile, golden snail eggs contain various minerals and nutrients including protein, calcium and potassium. Sponge cake is one of several processed snacks that are often consumed and liked by people in Indonesia. Sponge cake has a delicious taste and quite economical selling value. One way to use golden snail eggs is by substituting chicken eggs with golden snail eggs (Pomacea canaliculata L.) in sponge cakes. The aim of this research is to determine the results of organoleptic tests as well as the protein, calcium and potassium content of sponge cake substituted with golden snail eggs. This experimental research used a completely randomized design (CRD). Golden snail eggs can be used as an ingredient in making sponge cakes. There were 5 treatments carried out to substitute golden snail eggs, namely 0 g (A0), 15 g (A1), 25 g (A2), 35 g (A3) and 50 g (A4). First, the golden snail eggs are washed, mixed with chicken eggs, vanilla, granulated sugar and developer, then stirred until evenly mixed. After the dough has risen, add sweetened condensed milk, vegetable oil, water and wheat flour and stir until evenly mixed. The finished dough is put into a baking dish then steamed for 40 minutes until cooked. The organoleptic test results showed significant differences in taste and texture parameters. Sample A1 was preferred by panelists, with a score of color (4,07), aroma (3,63), taste (4,17), texture (3,77) and acceptability (3,90), and contained protein of 5,40%, calcium 409,77% and potassium 73,72%.
PENGETAHUAN, SIKAP DAN PRAKTIK GIZI GURU PAUD DIPERBAIKI DENGAN INTERVENSI e-HEALTH PEGIA
Authors: Purnamasari Dyah Umiyarni , Briawan Dodik , Kustiyah Lilik , Tanziha Ikeu , Hermadi Irman
Published: June 2024

Preschool teachers play a crucial role in influencing children's eating patterns at school, which is of utmost importance considering the detrimental impact of malnutrition on preschool children's cognitive abilities. In order to improve preschool teachers' nutrition behavior, it is imperative to provide education on nutritional behavior. One effective approach is implementing nutrition education for teachers through e-Health, which offers numerous advantages such as easier access and wider reach. Therefore, this research aimed to analyze the effectiveness of the Pegia eHealth intervention in improving the knowledge, attitudes, and practices of preschool teachers regarding nutrition. The sample consisted of 24 teachers from eight preschool centers in Purwokerto City, Indonesia. The e-Health intervention was conducted for 12 weeks, and the differences before and after the intervention were analyzed using the Wilcoxon test. The results showed a significant increase in the median knowledge by 12.00 with an interquartile range (IR) of 14.00, the median attitudes by 10.50 (IR: 8.75), and the median nutrition practices by 7.00 (IR: 3.00) (p-value < 0.05). The Pegia eHealth intervention showed its effectiveness in improving the nutrition knowledge, attitudes, and practices of preschool teachers.
ANALISIS DUKUNGAN ORANG TUA TERHADAP PROGRAM PEMBERIAN TABLET TAMBAH DARAH REMAJA PUTRI
Authors: Dwiyana Parlin , Angesti Annisa Nursita , Prikhatina Ratih Agustin , Kharisma Kharisma , Salsabila Dhea Marliana
Published: June 2024

Adolescent girls are a group that is vulnerable to experiencing nutritional problems such as anemia, which is characterized by hemoglobin levels in the blood that are lower than normal. Factors that support compliance with the consumption of blood supplement tablets in adolescent girls include perception, knowledge, motivation, attitudes, and family and teacher support regarding anemia and blood supplement tablets administration. This research aims to determine the relationship between the knowledge and characteristics of parents on parental support in implementing the blood supplement tablets program for adolescent girls. This research used a cross-sectional design located at MAN 3 Jakarta with 96 parents of adolescent girls as respondents. Data were analyzed using the Chi-Square test. The results showed that there was a relationship between the father's occupation and parental support (p=0.005), the father's income and parental support (p=0.000), the father's education and parental support (p=0.006), the mother's education and parental support (p=0.000), and parental knowledge with parental support (p=0.001). Thus, the father's occupation, the father's income, the father's education, the mother's education, and parental knowledge are factors related to parental support for the blood supplement tablets program for adolescent girls
Morphometric Characteristics and Condition Factors of Green Shells (Perna viridis) in The Waters of Randusanga Kulon Brebes, Central Java
Authors: Faizah Farkhah Nur , Imlani Ainulyakin Hasan , Sanjayasari Dyahruri
Published: June 2024

ABSTRACT
Green mussel (Perna viridis) is one of the species of bivalve class that is commonly found in the waters of Randusanga kulon, Brebes, thus becoming one of the sources of income for the people in the area. The purpose of this study was to determine the morphometric condition of green mussels based on length and weight and condition factors of green mussels in Randusanga kulon waters. Was used in this study regression analysis quantitative method. The results of the study showed the green mussel morphometry average length was 11.78 cm ± 1.51 with average weight was 90.749 gr ± 24.1. The value of b from the length-weight relationship of green mussels is 0.0045, meaning that the value of b <3 is allometrically negative, namely the growth of length faster than its weight. The condition factor of green mussels was 1.02, which is classified as having a good proportions and indicates a decent water condition.
Keywords: Condition Factors, Green Mussels, Morphometry,Growth, Randusanga Kulon
ABSTRAK
Kerang hijau (Perna viridis) merupakan salah satu spesies dari kelas bivalvia yang banyak ditemukan di perairan Randusanga kulon, Brebes, sehingga menjadi salah satu sumber pendapatan masyarakat di daerah tersebut. Tujuan dari penelitian ini adalah untuk mengetahui kondisi morfometrik kerang hijau berdasarkan panjang dan berat serta faktor kondisi kerang hijau di perairan Randusanga kulon. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif analisis regresi. Hasil penelitian menunjukkan morfometri kerang hijau panjang rata-rata adalah 11,78 cm ± 1,51 dengan berat rata-rata 90,749 gr ± 24,1. Nilai b dari hubungan panjang-berat kerang hijau adalah 0,0045, artinya nilai b < 3 bersifat allometrik negatif, yaitu pertumbuhan panjang lebih cepat dibandingkan dengan beratnya. Faktor kondisi kerang hijau sebesar 1,02 yang tergolong memiliki proporsi yang baik dan mengindikasikan kondisi perairan yang layak.
Kata Kunci: Faktor Kondisi ,Kerang Hijau, Morfometri, Pertumbuhan, Randusanga Kulon
Climate Change and Dew and Rain Evolution in Semi-arid South-Western Madagascar between 1991 and 2033 (Extrapolated)
Authors: Rasoafaniry Adriana , Muselli Marc , Beysens Daniel
Published: June 2024

In the context of global warming and increasing scarcity of fresh water resources, it becomes significant to evaluate the contribution and evolution of non-rainfall waters such as dew. This study therefore aims to evaluate the relative dew and rain contributions in three sites of south-western of Madagascar (Ifaty, Toliara and Andremba), a semi-arid region which suffers from a strong water deficit. The studied period is 1/1991 – 7/2023, with extrapolation to 8/2033. Dew is calculated from meteo data by using a well-established energy model. The extrapolation of dew and rain follows an artificial neural network approach. It is found that dew forms regularly (2-3 days in average between events), in contrast to rain (10-15 days). The evolutions of dew and rain are similar, with an increase from 1991 to 2000, a decrease up to 2020 and a further increase until 2033. These oscillations follow the Indian Ocean dipole variations and should be influenced by the climate change. Dew contribution to the water balance remains modest on a yearly basis (3-4%) but is important during the dry season (Apr.-Oct.), up to 30%. Dew therefore appears to be a reliable and sustainable resource for plants, small animals and population, especially during droughts.
Polyacetylene Prepared by Chemical Dehydration of Poly(vinyl Alcohol)
Authors: Carotenuto Gianfranco , Nicolais Luigi
Published: June 2024

Recently, polyacetylene (PA) is receiving a renewed scientific attention due to its electrical properties potentially useful for energy applications (e.g., fabrication of electrodes for batteries and supercapacitors) and unique functional characteristics (e.g., flame retardant, oxygen scavenger, EMI-shielding, etc.). This chemical compound can be obtained in form of a polyacetylene-PVOH copolymers simply by chemical dehydration of poly(vinyl alcohol) (PVOH), which is a very common type of polymer, widely used in packaging and other technological areas. This very inexpensive chemical reaction for the large-scale synthesis of PA/polyvinylenes has been investigated by reacting PVOH with fuming sulfuric acid at room temperature. In this process, PVOH, shaped in form of film, is dipped in fuming sulfuric acid (i.e., H2SO4 at 95-97%) and, after complete chemical-dehydration, it has been mechanically removed from the liquid phase by using a nylon sieve. The reduction process leads to a substantial PVOH film conversion to PA as it has been proved by infrared spectroscopy (ATR-mode). Indeed, the ATR spectrum of the reaction product included all characteristic absorption bands of PA. The reaction product has been also characterized by UV-Vis spectroscopy in order to evidence the presence in the structure of conjugated carbon-carbon double bonds of various lengths. Differential scanning calorimetry (DSC) and thermogravimetric analysis have been used respectively to investigate the PA solid-state cis-trans isomerization and thermal stability in air and nitrogen, respectively.
How to Parallelize “Non-Parallelizable” Minimization Functions
Authors: Lukyanenko Dmitry , Torbin Sergei , Shinkarev Valentin
Published: June 2024

The paper proposes a universal algorithm for parallelizing calculations that arise when using highly-optimized minimization functions available in many computing packages. The main idea of the proposed algorithm is based on the fact that although the “inner workings” of the minimization function used may not be known to the user, it inevitably uses in its work auxiliary functions that implement the calculation of the minimized functional and its gradient, which are usually implemented by the user, which means that in most cases they can be parallelized relatively easily. The paper discusses in detail both the parallelization algorithm and its software implementation using MPI parallel programming technology. Examples of the software implementation of the proposed algorithm are demonstrated using the Python programming language, but can be easily rewritten using the C/C++/Fortran programming languages.
Towards Universal Applied Supervised Machine Learning: A Multi-Agent Framework For Systematic Pipeline Executions
Authors: Pedrosa Diogo , Gaspar Iago
Published: June 2024

This paper presents MADS (Multi-Agents for Data Science), an innovative and simple open-source multi-agent framework designed for systemic pipeline execution in applied supervised machine learning. By leveraging the capabilities of multi-agent systems (MAS), we introduce a universal approach to optimize and streamline machine learning pipelines. Our framework highlights the differences between various types of agents, such as reinforcement learning (RL) agents and large language model (LLM) agents, and their distinct contributions to the process. While we currently employ LLM agents to automate and enhance machine learning tasks, we acknowledge the potential of incorporating RL agents in future iterations to further improve performance and adaptability. The primary objective is to enhance the efficiency, scalability, and adaptability of supervised learning applications across various domains. This integration addresses the complexity and manual effort typically associated with machine learning workflows, paving the way for more automated, robust, and scalable solutions. Our approach demonstrates significant improvements in task automation, reduced human intervention, and enhanced model performance. The MADS framework, which will soon be available as an open-source implementation, represents a pivotal contribution to the field of machine learning, promising to facilitate broader adoption and collaborative advancement.
Comparison of Peptidomes Extracted from Healthy Tissue, Tumour Tissue of the Parotid Glands and Saliva Samples
Authors: Puchalski Michał , Tretiakow Dmitry , Skorek Andrzej , Szydłowski Konrad , Stodulski Dominik , Miklaszewski Bogusław , Odroniec Amadeusz , Musiał Natalia , Thiel Marcel , Czaplewska Paulina , Ołdziej Stanisław
Published: June 2024

Salivary gland tumors are highly variable in clinical presentation and histology. The World Health Organization (WHO) classifies 22 types of malignant and 11 types of benign tumors of the salivary glands. Diagnosis of salivary gland tumors is based on imaging (ultrasound, magnetic resonance imaging) and fine-needle aspiration biopsy, but the final diagnosis is based on histopathological examination of the removed tumor. In this pilot study, we are testing a new approach to identifying peptide biomarkers in saliva that can be used to diagnose salivary gland tumors. The research material for the peptidomic studies was extracts from washings of neoplastic tissues and healthy tissues (control samples). At the same time, saliva samples from patients and healthy individuals were analysed. The comparison of the peptidome composition of tissue extracts and saliva samples may allow the identification of potential peptide markers of salivary gland tumors in patients' saliva. The peptidome composition extracted from 18 tumor and 18 healthy tissue samples, patient (11 samples) and healthy saliva samples (8 samples) was analysed by LC-MS tandem mass spectrometry. A group of 109 peptides were identified that were present only in the tumor tissue extracts and in the patient saliva samples. Some of the identified peptides were derived from proteins previously suggested as potential biomarkers of salivary gland tumors (ANXA1, BPIFA2, FGB, GAPDH, HSPB1, IGHG1, VIM) or tumors of other tissues or organs (SERPINA1, APOA2, CSTB, GSTP1, S100A8, S100A9, TPI1). Unfortunately, none of the identified peptides were present in all samples analysed. This may be due to the high heterogeneity of this type of cancer. The surprising result was that extracts from tumor tissue did not contain peptides derived from salivary gland-specific proteins (STATH, SMR3B, HTN1, HTN3). These results could suggest that the developing tumor suppresses the production of proteins that are essential components of saliva.
Groundwater Springs Influence Fish Community Distribution and Trout Condition across a Longitudinal Gradient in a Coldwater Catchment in Southeastern MN, USA
Authors: Varela Will L. , Mundahl Neal D. , Staples David F. , Bergen Silas , Cochran-Biederman Jennifer , Weaver Cole R. , Thoms Martin C.
Published: June 2024

The thermal conditions of transitional (ranging from warm to cold) coldwater streams impact the ranges and resource availabilities for biota inhabiting these lotic systems. With ongoing climate change and increasing land modifications, thermal boundaries may shift, altering thermal transition zones and their biotic communities. The objective of this study was to investigate the condition of trout across three forks of the Whitewater River catchment and to investigate factors influencing fish community composition and distribution. Each fork was characterized into three separate sections: headwater (coolwater), middle (warmwater), and lower (coldwater). Springs were identified throughout each fork, with greatest concentrations in the lower sections of each fork. Using single-pass electrofishing, we sampled 61 sites across the three forks in the Whitewater River system (North = 21 sites, Middle = 19, South = 21), and catch statistics were used to calculate diversity, trout abundance, and trout condition. In general, diversity increased, and trout were healthier but less abundant in middle and headwater sections, whereas diversity decreased slightly, trout condition decreased, and trout abundance increased in lower reaches, with changes differing somewhat among forks. Canonical correlation analysis had strong significant correlations showing simpson diversity and condition increase going upstream with high non trout abundance and catch rates while trout catch rates and reach width decrease. The Whitewater River is a catchment exhibiting transitional temperature-pattern characteristics with generally low fish community diversity and trout conditions that range from thin, normal, and robust. Dominated by a changing landscape (agriculture) and intensifying climate change, we may begin to see stream temperatures increase along with species diversity. Understanding how spring temperature influences species composition and distribution can bring potential stressors to light increasing our understanding of thermal conditions and to help mitigate the negative impacts from land use and climate change.
Supply Chain and Marketing Alignment in Launching New Products: Lessons From High-Tech Startups
Authors: Holloway Samuel
Published: June 2024

Aligning supply chain and marketing functions is crucial for high-tech startups aiming to successfully launch new products in competitive markets. This qualitative research explores the strategies, challenges, benefits, and best practices associated with supply chain and marketing alignment in high-tech startups. Through a detailed analysis of case studies and semi-structured interviews with industry professionals, the study identifies key insights into how startups can effectively integrate these functions to enhance operational efficiency, market responsiveness, customer satisfaction, and risk management. The findings reveal that successful alignment requires the formation of cross-functional teams, leveraging integrated technologies like CRM and ERP systems, establishing regular inter-departmental communication, and developing joint performance metrics. These strategies foster collaboration and ensure that supply chain and marketing efforts are coordinated towards shared goals. However, startups face challenges such as differing departmental objectives, resource constraints, communication barriers, and technological limitations, which hinder effective alignment. Benefits observed from effective alignment include improved operational efficiency through streamlined processes, enhanced market responsiveness to adapt quickly to changing demands, increased customer satisfaction by delivering products that meet market expectations, and better risk management through proactive identification and mitigation of supply chain and market risks. Best practices identified include fostering a culture of collaboration, investing in technology for data integration and transparency, aligning strategic objectives across functions, and continuously monitoring and adjusting alignment strategies. Integration of broader elements such as sustainability, entrepreneurship, emotional intelligence, marketing, and supplier relationship management further enriches the alignment framework. This study contributes to a deeper understanding of how high-tech startups can strategically align their supply chain and marketing functions to achieve competitive advantage and sustainable growth in dynamic market environments.
Dipyrone-induced inappropriate antidiuretic hormone secretion: a case report
Authors: Hindy Jawad , Rainis Tova , Greenberg Dana
Published: June 2024

The syndrome of inappropriate antidiuresis (SIAD) is a rare and significant side effect of a variety of medications such as antidepressants, chemotherapeutic medications, and non-steroidal anti-inflammatory drugs. Regarding dipyrone, only a few cases have been mentioned in the world. The non-opioid analgesic metamizole (dipyrone) is used for the treatment of acute or chronic pain and fever and is one of the most frequently prescribed over-the-counter medications in Israel, Brazil, and Mexico. Dipyrone has low anti-inflammatory properties yet inhibits prostaglandins to some degree. In this case report, we present a case of a post-operative patient, who was on an analgesic cocktail containing dipyrone. The patient developed a new and sudden hyponatremia, namely, a drop of 12 meq/L of sodium in less than 24 hours. Dipyrone was found to be the culprit drug. Our case report demonstrates the importance of considering dipyrone in the diagnosis of medication-induced SIAD in patients taking analgesics.
When Infection Lurks Behind Malignancy: A Unique Case of Primary Bone Lymphoma Mimicking Infectious Process in the Spine
Authors: Jaafari Ayoub , Rizzo Ornella , Mansour Sohaïb , Chbabou Anas , Trepant Anne-Laure , Attou Rachid , Mathey Céline
Published: June 2024

Primary bone lymphoma of the spine (PBL) is a rare entity and the most shared type of non-Hodgkin lymphoma (LNH) appearing in bone lesions deprived of nodal or extra-nodal in-volvement and accounting for approximately 2% of all lymphomas. Most PBL are diffuse large B-cell lymphomas (DLBCL) and commonly involve the appendicular skeleton. Due to its atypical location and non-specific clinical imaging features mimicking certain neoplastic or infectious processes, this pathology may be misdiagnosed, thus complicating and delaying diagnosis. Our case reports a patient in her sixties who had been suffering from chronic low back pain for a year, and had gradually started to develop cruralgia and fever. She underwent a blood sample, magnetic resonance imaging (MRI), and positron emission tomography (18F-FDG-PET/CT) which revealed significant inflammatory syndrome, a pattern of spondylodiscitis at the L3-L4 level associated with morphological and metabolic invasion extending posteriorly, raising suspicion of epiduritis. No other lesions were found on the rest of the body. Neurosurgical management was performed and a biopsy was made. Histological results showed aggressive and diffuse large B-cell lymphoma, suggesting a diagnosis of PBL. This case highlights the first case of spondylodiscitis mimicking PBL in the lumbar spine, the intricacies of the diagnostic work-up, and the complexity of discriminating with an infectious process in the spine, as both have a similar, non-specific clinical presentation with different prognosis and therapeutic management.
Schrödinger’s Cat Paradox Is an Illusion, We Are All Quantum Illusions When Seen From the Universal Quantum Referential
Authors: Durand Jean-Olivier
Published: June 2024

At the beginning of our observations, humanity believed that the Earth was the center of the uni-verse and that the sun was spinning around the Earth. Claude Ptolémée (100-168) made a mistake by modelling the movements in the geocentric referential, the model of the sun and planet move-ments was an illusion and all Humanity was wrong. Nicolas Copernic (1473-1543) showed the illusion and simplified the system by moving from the geocentric referential to the heliocentric referential. In the present paper, I would like to discuss about the possibility of making mistakes with quantum theory because we are all in the wrong classical referential. In my interpretation, the decoherence problem and wave function collapse do not exist at all, because we are the illusion, we are living in a quantum illusion, in a mirage. It is impossible to observe the quantum world as it is, in our classical referential, and we see the quantum world with a false vison of quantum reality be-cause we are not yet in the universal quantum referential whose I postulate the existence. As we are quantum illusions when seen from this universal quantum referential, Schrödinger’s cat paradox is a non-sense as life and death are illusions. We must be very humble with quantum theory and we should not put ourselves in the center of the quantum world again particularly with our lives and deaths. We will thus be collectively able to reach the universal quantum referential by changing our vision of life and quantum world. This will be our Big Bang.
Hemodynamic Evaluation of Coronary Artery Lesions After Kawasaki Disease: Comparison of FFR During Cardiac Catheterization With MFR During 13N-Ammonia PET
Authors: Watanabe Makoto
Published: June 2024

Coronary artery lesions (CALs) after Kawasaki disease present complex coronary hemodynamics. We investigated the relationship between coronary fractional flow reserve (FFR), myocardial blood flow reserve (MFR), and myocardial blood flow volume fraction (MBF), and their clinical usefulness in CALs after Kawasaki disease. Nineteen patients (18 male, 1 female) who underwent cardiac catheterization and 13N-ammonia positron emission tomography, with 24 coronary artery branches, were included. Five branches had inconsistent FFR and MFR values, two had normal FFR but abnormal MFR, and three had abnormal FFR and normal MFR. The abnormal MFR group had significantly higher MBF at rest than the normal group (0.86±0.13 vs. 1.08±0.09, p=0.001). The abnormal FFR group had significantly lower MBF at adenosine loading than the normal group (2.23±0.23 vs. 1.88±0.29, p=0.021). The three branches with abnormal FFR only had stenotic lesions, but the MFR may have been normal because blood was supplied by collateral vessels. Combining FFR, MFR, and MBF will enable a more accurate assessment of peripheral coronary circulation and stenotic lesions in CALs and help determine treatment strategy and timing of intervention.
The Indispensable Role of Bacteria in Human Life and Environmental Health
Authors: Gupta PD , Skiba Dominika , Sawicka Barbara
Published: June 2024

Background: Bacteria, among the earliest life forms on Earth, are integral to both human health and environmental ecosystems. They contribute to essential processes such as digestion, nutrient absorption, and immune defense, and play key roles in the biogeochemical cycles that sustain life. Objective: This paper explores the indispensable role of bacteria in human life and environmental health, emphasizing their contributions to digestion, nutrient absorption, immune protection, and ecosystem functioning. It also discusses advances in understanding the human microbiome and their implications for health and therapeutic interventions. Methods: The study reviews existing literature on the human microbiome, probiotics, and the role of bacteria in environmental nutrient cycling. It analyses experimental evidence and case studies, particularly focusing on the impact of fecal microbiota transplantation (FMT) as a therapeutic tool. Metagenomic analysis techniques are examined to highlight the diversity and functionality of gut bacteria. Results: Bacteria are found to be essential for breaking down food, providing vital nutrients, and protecting against pathogens. They play a critical role in maintaining a healthy immune system and are involved in the biogeochemical cycles necessary for ecosystem health. Metagenomic analysis reveals significant variations in bacterial populations associated with health and disease, emphasizing the importance of a balanced microbiota. FMT shows promise as an effective treatment for various diseases, including gastrointestinal, metabolic, and neurological disorders. Conclusions: Bacteria are crucial for human health and environmental stability. Maintaining a balanced microbiota is vital for overall well-being, and interventions such as probiotics and FMT can offer significant health benefits. Future research should focus on further understanding the complex interactions between bacteria and their hosts to develop targeted therapies for various health conditions.
Mesoscale Eddies and their Impact on Primary Productivity in the Bay of Bengal
Authors: Ahmad Hafez , Jose Felix , Dash Padmanava , Jhara Shakila Islam
Published: June 2024

Mesoscale eddies wield a significant influence on primary productivity in marine ecosystems by regulating nutrient availability, vertical mixing, and phytoplankton growth dynamics. In this study, we tracked and analyzed the effects of mesoscale eddies on net primary productivity (NPP) across the Bay of Bengal (BoB) using remote sensing data. Dividing the Bay into six zones based on mesoscale eddy frequency and distribution, our analysis identified 1880 anticyclonic eddies and 1972 cyclonic eddies during January 2010–March 2020 monitoring period. Cyclonic eddies predominantly occurred in the western part of the bay - along the east coast of the Indian Peninsula; while anticyclonic eddies were also observed, albeit in lesser proportions. Among eddies lasting one-week, anticyclonic eddies comprised approximately 48.81%, while cyclonic eddies constituted approximately 51.19% of the total. Analysis of the NPP distribution across the months revealed intriguing patterns. Mean values of NPP fluctuated throughout the year, with the highest value observed in August (748.51 mg C/m2/day) and the lowest in May (519.26 mg C/m2/day). The findings indicate a complex relationship between eddy distribution and NPP, with Zones 1 and 2 exhibiting a higher occurrence of cyclonic eddies, correlating with greater NPP and its variability. Conversely, Zones 3 and 5 display increased eddy activity despite fewer cyclonic eddies and lower NPP levels. Zone 6 shows reduced eddy activity and NPP, while Zone 4 presents moderate eddy activity alongside lower NPP. In contrast, Zones 3 to 5 exhibit lower NPP levels despite exhibiting heightened eddy activity. This study contributes valuable insights into the dynamics of ocean circulation and the impacts of eddies on NPP, which can inform fisheries management strategies, advances climate resilience measures, expands scientific knowledge, and guides policies related to conservation and sustainable resource utilization.
The Interplay Between Multisystem Inflammatory Syndrome in Children, Interleukin 6, Microbiome, and Gut Barrier Integrity
Authors: Zari Ali , Redwan Elrashdy M. , Raszek Mikolaj , Cowley David , Hromić-Jahjefendić Altijana , Uversky Vladimir N. , Fabrowski Mark , Brogna Carlo , Piscopo Marina , Rubio-Casillas Alberto
Published: June 2024

A severe consequence of SARS-CoV-2 infection that manifests as systemic inflammation and multi-organ involvement is called Multisystem Inflammatory Syndrome in Children (MIS-C). This review examines the possible relationship between gut barrier integrity, the microbiome, dysregulation of interleukin-6 (IL-6) signaling, and MIS-C. Clinical and biochemical features of MIS-C are similar to those of other hyperinflammatory syndromes, suggesting a dysregulated immune response. One possible explanation for the systemic inflammation seen in MIS-C patients is SARS-CoV-2-induced dysregulation of the IL-6 signaling pathway. In addition, new data suggest a reciprocal link between gut barrier integrity and IL-6. SARS-CoV-2 exhibits bacteriophage-like behavior, highlighting the role of bacteria as a reservoir for the virus and emphasizing the importance of understanding the bacteriophagic mechanism of the virus in fecal-oral transmission. Increased translocation of viral products and bacterial toxins may result from disrupting the intestinal barrier and cause systemic inflammation. On the other hand, systemic inflammation can weaken the integrity of the intestinal barrier, which feeds back into the loop of immunological dysregulation. In the context of MIS-C, understanding the interaction between SARS-CoV-2 infection, IL-6, and gut barrier integrity may shed light on the etiology of the disease and guide treatment options.
German Chamomile (Matricaria chamomilla L.) Flowers Extract, Its Amino Acids Preparations and 3D-Printed Dosage Forms: Phytochemical, Pharmacological, Technological and Molecular Docking Study
Authors: Koshovyi Oleh , Sepp Janne , Jakštas Valdas , Žvikas Vaidotas , Kireyev Igor , Karpun Yevhen , Odyntsova Vira , Heinämäki Jyrki , Raal Ain
Published: June 2024

German chamomile (Matricaria chamomilla L.) is an essential oil-content medicinal plant widely used worldwidely. The aim of this study was (1) to gain knowledge of the phytochemical composition and the analgesic and soporific activity of M. chamomilla flowers extract and its amino acid preparations, (2) to predict the mechanisms of their effects by molecular docking, and (3) to develop aqueous printing gels and novel 3D-printed oral dosage forms for M. chamomilla flowers extracts. In total 22 phenolics and 14 amino acids were identified and quantified in the M. chamomilla extracts. The in-vivo animal studies with rodents showed that the oral administration of such extracts revealed the potential for treating of sleep disorders and diseases accompanied by pain. Amino acids were found to potentiate these effects. Glycine enhanced the analgesic activity the most, while lysine and β-alanine improved the soporific activity. The molecular docking analysis revealed a high probability of GABAA and NMDA receptor antagonism and COX-1,2 inhibition by the extracts. A polyethylene oxide (PEO) based gel composition with the M. chamomilla extracts were proposed for preparing a novel 3D-printed dosage form for the oral administration. These 3D-printed extract preparations can be used for example in dietary supplement applications.
New Physically-Based Mathematical Model and Experiments for a Recently Invented Solar Pot
Authors: Rátkai Márton , Géczi Gábor , Kicsiny Richárd , Székely László
Published: June 2024

The studied solar pot is a recent invention, which gained a utility model protection in 2021 from the Hungarian Intellectual Property Office under patent number 5489. The device is made for environmentally friendly cooking or heating (by utilizing solar energy) of foods and liquids. Its structure is similar to a double pipe heat exchanger, it has an outer mantle and an inner cooking tank. The goals of the paper are proposing a new physically-based mathematical model describing the solar pot and carrying out computer experiments with it, assembling an experimental system of the pot connected with a solar collector and performing measurements on it. Based on the results, the solar pot can successfully be used for cooking or sterilizing foods or liquids during the studied time period, in Hungary.
High Expression of AhR and Environmental Pollution As AhR Linked Ligands Impact on Oncogenic Signaling Pathways in Western Patients With Diffuse Gastric Cancers. A Pilot Study
Authors: Perrot-Applanat Martine , Pimpie Cynthia , Vacher Sophie , Pocard Marc , Baud Véronique
Published: June 2024

Diffuse type of gastric cancer (GC) has an increasing prevalence worldwide, especially in Western countries, is usually diagnosed at advanced stages, and has no efficacious treatment options. Epidemiological studies have reported an increased mortality from GC after occupational exposure to well-studied pro-carcinogen that are metabolically activated by Cyp P450 enzymes through aryl hydrocarbon receptor (AhR). Substantial studies support the involvement of AhR in gastric carcinogenesis. However, little is known about the role of AhR in diffuse GC, as compared to intestinal GC. In a cohort of 29 gastric tumors, we described a significantly increased AhR protein and mRNA expression levels in GCs, independently of subtypes and clinical parameters. AhR and RhoA mRNA expression were correlated in diffuse GC. Further, our study characterized how AhR affects gene expression in diffuse GC. Using qRT-PCR, we compared the expression levels of AhR, Cyp1A1 and Cyp1B1 to the expression of genes in a panel previously described. In diffuse GC, Cyp1A1 expression correlated with genes involved in IGF signalling, EMT (VIM), migration (MMP2). In an in vitro assay using the poorly differentiated KATOIII epithelial cell line, two well-known ligands for AhR (TCDD and BaP) induced mRNA expression of CYP1A1, IL1b, as well as UGT1, NQO1 and AhRR to a lower extent. We also observed a strong increase in Cyp1B1 expression in diffuse GC, along with a lower TCDD-increased Cyp1B1 expression as compared to Cyp1A1 in KATOIII cells, and immunostaining in stromal cells. In intestinal GC, Cyp1B1 inversely correlated with several genes including IDO1 (generating endogenous kynurenin-e AhR ligand). Our data provide evidence for a major role of AhR in GC, as an environmental xenobiotics receptor, through different mechanisms and pathways in diffuse and intestinal GC. Our results support continued efforts to clarify the identities of exogenous AhR ligands in diffuse GC in order to define new therapeutic strategies.
Assessment of Skeletal Muscle Alterations and Circulating Myokines in MASLD Patients: A Prospective Cohort Study
Authors: Real Martínez Yolanda , Fernandez-Garcia Carlos Ernesto , González-Rodríguez Agueda , Fuertes-Yebra Esther , Calvo Soto Mario , Berlana Angela , Barrios Vicente , Caldas Maria , González Moreno Leticia , García-Buey Luisa Consuelo , Molina Baena Begoña , Sampedro Nuñez Miguel , Beceiro Maria Jose , García-Monzón Carmelo
Published: June 2024

Aim: To determine the prevalence of skeletal muscle alterations (SMA) in patients with meta-bolic dysfunction-associated steatotic liver disease (MASLD) and to assess the significance of circulating myokines as potential biomarkers of SMA in patients with MASLD. Material and methods: Measurements of both skeletal muscle strength and skeletal muscle mass parameters, anthropometric and metabolic features as well as serum levels of different myokines were per-formed in a cohort of 62 MASLD patients and then compared according to the stage of liver fi-brosis and hepatosteatosis degree both diagnosed by transitional elastography. Results: No sig-nificant differences were found in skeletal muscle strength and skeletal muscle mass in MASLD patients stratified according to the stage of liver fibrosis. Noteworthy, serum levels of FGF21 were significantly higher in MASLD patients with advanced hepatic fibrosis (F3-F4) than in those with lower stages of hepatic fibrosis (F0-F2) (197.49±198.27 pg/ml vs 95.62±83.67 pg/ml, p=0.049, respectively). MASLD patients with severe hepatosteatosis (S3) had significantly higher serum levels of irisin (1116.87±1161.86 pg/ml) than those with lower grades (S1-S2) (385.21±375.98 pg/ml, p=0.001).
Conclusion: SMA were uncommon in our MASLD patients, particularly in those with lower stages of liver fibrosis. An increase in serum FGF21 was detected in patients with a higher stage of fibrosis with possible therapeutic implications in MASLD.
Study on the Measurement of the the Grain Industry Chain Resilience and its Influencing Factors: A Case from China
Authors: Ma Song Lin , Wang Ping ping
Published: June 2024

Food security is the cornerstone of national security, and exploring the resilience of the grain industry chain is particularly important under the current complex and changing external environment. The study is to evaluate the grain industry chain resilience and identify its influencing factors. Based on the panel data of 30 provinces (cities) in China from 2011 to 2022, this paper adopted Partial Least Squares structural equation modeling method to carry out comprehensive evaluation, applied Dagum Gini coefficient to analyze spatial differences, and used geo-detectors to identify the influencing factors. The results showed that (1) from an overall perspective, the resilience of China's grain industry chain showed an overall upward trend, and each region had been greatly improved; (2) from the perspective of spatial differences, the overall spatial variability of China's grain industry chain is relatively small, and the gap mainly originates from inter-regional differences; (3) from the perspective of influencing factors, the level of grain foreign trade, regional market size and agricultural innovation level were important factors. In order to enhance the resilience of China's grain industry chain, based on the heterogeneous characteristics, the coordinated development of each region should be integrated, and the endogenous power should be given full play to enhance the resilience of the industry chain.
How Supply Chain Innovations Drive Marketing Differentiation: A Qualitative Analysis of Consumer Goods Companies
Authors: Holloway Samuel
Published: June 2024

This qualitative research investigates how supply chain innovations drive marketing differentiation in consumer goods companies. In a competitive global marketplace, firms are increasingly leveraging advanced supply chain management (SCM) practices to enhance operational efficiency and create distinctive market positions. The study explores five key supply chain innovations—digitalization, sustainability practices, predictive analytics, agile supply chain models, and collaborative partnerships—and their impact on marketing differentiation strategies. Data were collected through semi-structured interviews with 20 executives and managers from leading consumer goods companies, analyzing themes related to innovation adoption, challenges, and outcomes. Findings indicate that digital technologies such as IoT, AI, and blockchain are pivotal in improving supply chain visibility, optimizing inventory management, and enabling real-time decision-making, thereby supporting personalized customer experiences and agile responses to market dynamics. Sustainability practices, including sustainable sourcing and green logistics, emerge as critical drivers of brand reputation and consumer trust, aligning with growing consumer preferences for eco-friendly products. Predictive analytics facilitate better demand forecasting and pricing strategies, while agile supply chain models enhance flexibility and responsiveness in delivering products faster to market. Despite benefits, challenges include integrating innovations with legacy systems, managing resistance to change, and addressing data security concerns. Strategies for overcoming these barriers include leadership commitment, cross-functional collaboration, talent development, and strategic partnerships. By embracing these strategies and innovations, consumer goods companies can strengthen their competitive positioning, enhance customer satisfaction, and achieve sustainable growth in a rapidly evolving marketplace.
Molecular TiO2 Modifications of Supported PPh3-Capped Pd Nanocatalysts for the CO2 Hydrogenation into Formates
Authors: Godard Cyril , Fernández Martínez María Dolores
Published: June 2024

TiO2-supported Pd-NPs based materials were prepared following two distinct approaches: for the first set of materials 1-8, modification of the TiO2 support was performed prior to Pd NPs deposition while the 2nd set (9-15) was synthesized by deposition of modifiers over pre-synthesized Pd-PPh3/TiO2. These catalysts were applied in the hydrogenation of CO2 to formate and their performance compared with that of the unmodified Pd-PPh3/TiO2. Modification of the TiO2 support by organosilanes provided a beneficial effect in catalysis compared with the catalyst containing unmodified TiO2 or TiO2 modified by organophosphonic acids. In contrast, in most cases, the deposition of modifiers over previously synthesized Pd NPs supported on TiO2 was not beneficial to the activity of the catalyst. Interestingly, upon recycling, the first set of catalysts suffered a rapid decrease in activity while the anchoring of modifiers over previously formed Pd NPs showed an improved stability (TON > 500 after the 3rd recycling).
Exploring the Relationship Between Supply Chain Responsiveness and Customer Loyalty in the E-commerce Sector
Authors: Holloway Samuel
Published: June 2024

This qualitative study explores the relationship between supply chain responsiveness (SCR) and customer loyalty within the e-commerce sector. E-commerce has revolutionized global commerce, driven by technological advancements and shifting consumer behaviors. Central to e-commerce success is the ability to meet customer expectations swiftly and reliably, necessitating agile supply chain management (SCM) practices. SCR in e-commerce encompasses the capacity to adapt to dynamic market demands, minimize disruptions, and enhance customer satisfaction through efficient logistics, inventory management, and last-mile delivery. Through in-depth interviews with customers, e-commerce platform managers, and supply chain practitioners, this study investigates key themes, challenges, strategies, and impacts associated with SCR and customer loyalty. Findings reveal that customers prioritize fast order fulfillment, reliable service quality, personalized experiences, and trustworthy interactions, all of which significantly influence their loyalty and advocacy behaviors. Challenges identified include inventory management complexities, logistical hurdles in last-mile delivery, and the need for effective supplier communication. Strategic approaches to enhance SCR include leveraging data analytics for demand forecasting, adopting agile SCM practices, integrating customer feedback into service improvements, and fostering collaborative relationships with suppliers. These strategies not only optimize operational efficiency but also cultivate enduring customer relationships based on satisfaction, trust, and loyalty. The study concludes that improved SCR practices lead to increased customer satisfaction, repeat purchases, and positive word-of-mouth, thereby strengthening competitive advantage and sustainability in the e-commerce marketplace.
Recombinant C-terminal Catalytic Domain of Rat L-gulono Lactone Oxidase Produced in Bacterial Cells Is Enzymatically Active
Authors: Gad Abdul Aziz Mohamed , Gora-Sochacka Anna , Sirko Agnieszka
Published: June 2024

L-gulonolactone oxidase enzyme (GULO) catalyzes the last step of L-ascorbic acid (vitamin C) biosynthesis. This enzymatic activity is lost in primates. The full-length rat GULO has been previously produced in plants and demonstrated to be active. In this study, we compare activity of two variants of GULO produced in Escheriachia coli cells, full-length rat GULO (fGULO) and its C-terminal catalytic domain (cGULO). The expression and purification of the recombinant proteins were optimised and their biological activity was confirmed by two methods, the GULO activity assay in the protein extracts and the ‘in-gel’ staining for GULO activity. Both variants of recombinant GULO were biologically active in both assays. However, cGULO is more promising than fGULO for ascorbic acid production because it is more efficiently produced by bacteria.