bluuebunny/crossref_metadata_2025 huggingface dataset:
Transient Ascaris suum larval migration induces intractable chronic pulmonary disease and anemia in mice
Authors: Wu Yifan , Li Evan , Knight Morgan , Adeniyi-Ipadeola Grace , Song Li-zhen , Burns Alan R. , Gazzinelli-Guimaraes Ana Clara , Fujiwara Ricardo , Bottazzi Maria Elena , Weatherhead Jill E.
Published: December 2021

Ascariasis is one of the most common infections in the world and associated with significant global morbidity. Ascaris larval migration through the host’s lungs is essential for larval development but leads to an exaggerated type-2 host immune response manifesting clinically as acute allergic airway disease. However, whether Ascaris larval migration can subsequently lead to chronic lung diseases remains unknown. Here, we demonstrate that a single episode of Ascaris larval migration through the host lungs induces a chronic pulmonary syndrome of type-2 inflammatory pathology and emphysema accompanied by pulmonary hemorrhage and chronic anemia in a mouse model. Our results reveal that a single episode of Ascaris larval migration through the host lungs leads to permanent lung damage with systemic effects. Remote episodes of ascariasis may drive non-communicable lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), and chronic anemia in parasite endemic regions.
Association between grip strength and anthropometric characteristics in the community-dwelling elderly population in Taiwan
Authors: Lin Ming-Hsun , Chang Chun-Yung , Lu Chieh-Hua , Wu Der-Min , Kuo Feng-Chih , Kuo Che-Chun , Chu Nain-Feng
Published: December 2021

Background

Sarcopenia and muscle weakness in elderly are contributed burden of public health and impact on quality of life. Weak grip strength was key role in diagnosis of sarcopenia and reported increased mortality, function declined in elderly. This study evaluated the association between GS and each common anthropometric characteristic in community-dwelling elderly.

Design and method

From 2017 to 2019, we conducted a community-based health survey among the elderly in Chiayi county, Taiwan. Participants were 65 years old or older, and total of 3,739 elderly subjects (1,600 males and 2,139 females) with a mean age of 76 years (range 65–85 years old) were recruited. General demographic data and lifestyle patterns were measured using a standard questionnaire. Anthropometric characteristics such as body height, body weight, body mass index (BMI), body waist and hip circumference, and body fat were measured by standard methods. GS was measured using a digital dynamometers (TKK5101) method.

Results

The mean GS was 32.8 ± 7.1 kg for males and 21.6 ± 4.8 kg for females (p < 0.001). For both sexes, elderly subjects with the same body weight but smaller body waist circumference had greater GS. The subjects with the same body waist size but heavier weight had greater GS. Furthermore, after adjusting for age, lifestyles, disease status, and potential anthropometric variable, multivariate regression analyses indicated that BMI was positively associated with GS (for males, beta = 0.310 and for females beta = 0.143, both p < 0.001) and body waist was negatively associated with GS (for males, beta = −0.108, p < 0.001; for females, beta = −0.030, p = 0.061).

Conclusions

This study suggested that old adults with higher waist circumstance had weaker GS. Waist circumstance was negatively associated with GS, body weight was positively associated with GS in contrast. It may implies that central obesity was more important than overweight for GS in elderly.
The implications of parent mental health and wellbeing for parent-child attachment: A systematic review
Authors: Risi Alixandra , Pickard Judy A. , Bird Amy L.
Published: December 2021

Background

Parent mental health and wellbeing may have implications for understanding attachment transmission. In this systematic review, we synthesise the published literature to determine the nature of the relationship between parent mental health and wellbeing and the intergenerational transmission of attachment and to provide recommendations for future research, clinical practice and intervention.

Method

Using the preferred reporting items for systematic reviews and meta-analyses (PRISMA) approach, five electronic databases were searched for peer-reviewed empirical studies, published in English. Articles were considered for inclusion if data was collected on adult attachment, child attachment, and a domain of parent mental health/wellbeing. No date parameters were applied to the search strategy. The review was registered with PROPSERO (registration number: CRD42020157247).

Results

Eleven studies examining the impact on parent mental health and wellbeing on the intergenerational transmission of attachment were identified for inclusion in this review. Our review found preliminary evidence that parent mental health and wellbeing play a role in the intergenerational transmission of attachment. Other key findings from the review were: evidence quality is mixed due to variable measurement of attachment and mental health; studies have mostly included correlational analysis or do not utilise contemporary methodological approaches to testing mediating or moderating relationships; and literature is largely focused on psychopathology and negative factors of mental health.

Conclusions

The limited scope of parent mental health and wellbeing constructs examined in the literature, the sparse use of robust statistical analyses, and the lack of literature in general makes it difficult to draw conclusions on how and why parent mental health impacts attachment transmission. Addressing these limitations will further progress attachment-related literature and may have particular implications for attachment-informed interventions with clinical populations.
Whole-genome based strain identification of fowlpox virus directly from cutaneous tissue and propagated virus
Authors: Asif Kinza , O’Rourke Denise , Legione Alistair R. , Shil Pollob , Marenda Marc S. , Noormohammadi Amir H.
Published: December 2021

Fowlpox (FP) is an economically important viral disease of commercial poultry. The fowlpox virus (FPV) is primarily characterised by immunoblotting, restriction enzyme analysis in combination with PCR, and/or nucleotide sequencing of amplicons. Whole-genome sequencing (WGS) of FPV directly from clinical specimens prevents the risk of potential genome modifications associated within vitroculturing of the virus. Only one study has sequenced FPV genomes directly from clinical samples using Nanopore sequencing, however, the study didn’t compare the sequences against Illumina sequencing or laboratory propagated sequences. Here, the suitability of WGS for strain identification of FPV directly from cutaneous tissue was evaluated, using a combination of Illumina and Nanopore sequencing technologies. Sequencing results were compared with the sequence obtained from FPV grown in chorioallantoic membranes (CAMs) of chicken embryos. Complete genome sequence of FPV was obtained directly from affected comb tissue using a map to reference approach. FPV sequence from cutaneous tissue was highly similar to that of the virus grown in CAMs with a nucleotide identity of 99.8%. Detailed polymorphism analysis revealed the presence of a highly comparable number of single nucleotide polymorphisms (SNPs) in the two sequences when compared to the reference genome, providing essentially the same strain identification information. Comparative genome analysis of the map to reference consensus sequences from the two genomes revealed that this field isolate had the highest nucleotide identity of 99.5% with an FPV strain from the USA (Fowlpox virus isolate, FWPV-MN00.2, MH709124) and 98.8% identity with the Australian FPV vaccine strain (FWPV-S, MW142017). Sequencing results showed that WGS directly from cutaneous tissues is not only rapid and cost-effective but also provides essentially the same strain identification information asin-vitrogrown virus, thus circumventingin vitroculturing.
Protocol: A mixed methods evaluation of an IPS program to increase employment and well-being for people with long-term experience of complex barriers in Vancouver’s downtown and DTES
Authors: Kwan Amanda , Morris Jonny , Barbic Skye P.
Published: December 2021

Background

Employment improves mental health and well-being by providing financial security, daily structure, a sense of identity and purpose, and social engagement. However, securing and sustaining employment is exceptionally challenging for vulnerable populations who experience persistent and multiple barriers, such as mental illness, homelessness, food and housing insecurity, and marginalization. Evidence-based supported employment programs, most notably individual placement and support (IPS) are becoming a more common approach for addressing the needs of these high-risk individuals. The aim of this paper is to outline the protocol for evaluating an IPS program in Vancouver’s downtown and Downtown Eastside (DTES).

Methods and design

This prospective quasi-experimental study of persons with persistent and multiple barriers to employment will use a mixed-methods approach for evaluating a novel IPS program. The evaluation will consist of survey packages and interviews that will capture outcomes related to employment and well-being, as well as the experiential process of receiving individualized and integrated supports through the IPS program. A mixed-methods approach is appropriate for this study as quantitative data will provide an objective assessment of program impacts on employment and well-being outcomes over time, while qualitative data will provide an in-depth understanding of continued barriers and experiences.

Discussion

The results from this evaluation will contribute evidence within a local British Columbian (BC) context that may increase access to meaningful employment for those with long-term experience of complex barriers to employment. Further, the findings will support continued improvements, and guide decision-making around practices and policy for future implementation of IPS and employment supports across BC.
Understanding the role of retail therapy (RT) on body shame, weight preoccupation and body mass index (BMI)
Authors: Goyal Simar , Yoo Jeong-Ju
Published: December 2021

The goal of the study is to understand the effect of retail therapy (RT) based on individuals’ body shame, body mass index (BMI) and weight preoccupation. A total of 285 female college students, with an average age of 20.55 years, were collected. Analysis of variance (ANOVA) was performed to compare four types of RT (i.e. therapeutic shopping motivation, positive mood reinforcement, negative mood reduction and therapeutic shopping outcomes) based on the degree of body shame, BMI and weight preoccupation. The effect of RT was significantly stronger for individuals who experience body shame. However, based on the individuals’ BMI, the effect of RT did not show statistical differences for any of the subcategories. Only negative mood reduction was significantly stronger for individuals who were highly preoccupied with their weight. Individuals who shop to compensate for personal features may do so to rectify negative perceptions of their weight. Retailers should focus on creating a shopping environment for plus-size consumers and provide a shopping environment that will change their weight perceptions by carrying a broader range of sizes in their stores. Mental health professionals should investigate RT as a modality to treat the symptoms of body image issues.
A Theoretical Study of Hydrogen-Bonded Complexes of
Ethylene Glycol, Thioglycol and Dithioglycol with Water
Authors: Kohli Ruchi , Kaur Rupinder Preet
Published: December 2021

In the present study, a theoretical analysis of hydrogen bond formation of ethylene glycol, thioglycol,
dithioglycol with single water molecule has been performed based on structural parameters of optimized
geometries, interaction energies, deformation energies, orbital analysis and charge transfer. ab initio
molecular orbital theory (MP2) method in conjunction with 6-31+G* basis set has been employed.
Twelve aggregates of the selected molecules with water have been optimized at MP2/6-31+G* level
and analyzed for intramolecular and intermolecular hydrogen bond interactions. The evaluated
interaction energies suggest aggregates have hydrogen bonds of weak to moderate strength. Although
the aggregates are primarily stabilized by conventional hydrogen bond donors and acceptors, yet
C-H···O, S-H···O, O-H···S, etc. untraditional hydrogen bonds also contribute to stabilize many
aggregates. The hydrogen bonding involving sulfur in the aggregates of thioglycol and dithioglycol is
disfavoured electrostatically but favoured by charge transfer. Natural bond orbital (NBO) analysis has
been employed to understand the role of electron delocalizations, bond polarizations, charge transfer,
etc. as contributors to stabilization energy.
Effect of Different Cavity Disinfectants on Microleakage
Authors: Unal Samican , Akbiyik Sema Yazici , Bakir Elif Pinar , Bakir Seyhmus
Published: December 2021

BACKGROUND Cavity disinfectants are frequently used for the elimination of bacteria that remain in the cavity, which are shown as the cause of secondary caries. However, its effect on microleakage from the tooth-restoration interface is still under investigation. The purpose of this study was to compare and evaluate the effects of the use of three different cavity disinfectants on microleakage in Class V composite restorations. METHODS For this study, 28 permanent third molar teeth without caries and restoration were used. Class V cavities of 4 mm x 3 mm x 3 mm were prepared on the buccal surfaces of each tooth. The teeth were randomly divided into 4 groups, with 7 teeth in each group. No cavity disinfectant was applied to the teeth in group 1. Tubulicid Red Label (Dental Therapeutics AB, Sweden) cavity disinfectant was applied to the 2nd group teeth, Cavity Cleanser (BISCO Inc., USA) cavity disinfectant to the 3rd group teeth, and Oxygenated Water (Dermosept, Turkey) cavity disinfectant to the 4th group teeth. Composite resin with universal adhesive and nanohybrid filler was applied to all samples in the groups in accordance with the recommendations of the manufacturers, and finishing and polishing processes were performed. Then, the thermal cycle (NOVA, Konya, Turkey) procedure was applied. After the restorations were covered with nail polish, they were kept in a 5 % basic fuchsin solution. The teeth were cut vertically in the buccolingual direction and examined with a stereomicroscope at x 40 magnification. The results were statistically evaluated with Kruskal-Wallis and Mann-Whitney U tests. RESULTS When the microleakage scores were compared between the control group and the groups treated with Tubulicid Red Label (p:0.204), Cavity Cleanser (p:0.204) and Oxygenated Water (P: 0.788), it was determined that there was no statistically significant difference (P > 0.05). CONCLUSİONS It was determined that different cavity disinfectants applied in Class V cavities did not have a negative effect on microleakage and the closest results to the control group were seen in the group where cavity cleanser disinfectant containing 2 % chlorhexidine digluconate was applied. KEY WORDS Cavity Disinfectants, Class V Cavity, Microleakage.
Gender bias in student evaluation of teaching or a mirage?
Authors: Uttl Bob , Violo Victoria
Published: December 2021

In a recent small sample study, Khazan et al. [1] examined SET ratings received by one female teaching (TA) assistant who assisted with teaching two sections of the same online course, one section under her true gender and one section under false/opposite gender. Khazan et al. concluded that their study demonstrated gender bias against female TA even though they found no statistical difference in SET ratings between male vs. female TA (p = 0.73). To claim gender bias, Khazan et al. ignored their overall findings and focused on distribution of six “negative” SET ratings and claimed, without reporting any statistical test results, that (a) female students gave more positive ratings to male TA than female TA, (b) female TA received five times as many negative ratings than the male TA, and (c) female students gave “most low” scores to female TA. We conducted the missing statistical tests and found no evidence supporting Khazan et al.’s claims. We also requested Khazan et al.’s data to formally examine them for outliers and to re-analyze the data with and without the outliers. Khazan et al. refused. We read off the data from their Figure 1 and filled in several values using the brute force, exhaustive search constrained by the summary statistics reported by Khazan et al. Our re-analysis revealed six outliers and no evidence of gender bias. In fact, when the six outliers were removed, the female TA was rated higher than male TA but non-significantly so.
An Innovative Project of a Bionic Robot for Social Applications in Felinotherapy
Authors: Litwin Sonia , Woźniak Klaudia , Olszewski Mariusz
Published: December 2021

The paper describes an innovative design of a bionic robot for applications in felinotherapy supporting hospital and home psychotherapeutic treatment of bedridden children and adults. The project was engineered by biomimicrating a biological cat, reaching its robotic model. Particular attention in this process was devoted to capturing the essence of feline motorics behavior and the possibility of mapping them in a mechatronic model. The geometry, kinematics and kinetics of this model were analyzed, creating assumptions for its practical implementation in the real mechanism of cat skeleton movement. The used software used the topology of elements in Autodesk Fusion 360 Simulation workspace by performing the critical elements of the mechatronic model in print using SLS technology. The work was also supported by a graphical simulation in the PyBullet environment.
Eficacia de la combinación de Abamectina-Derquantel y de la Moxidectina en cabras lecheras naturalmente parasitadas con nematodos gastrointestinales en el Valle de Lerma, Argentina
Authors: OLMOS Leandro Hipólito , MARTÍNEZ Gabriela M. , ALFARO Rodolfo J. , DIAZ Juan P. , SUAREZ Víctor H.
Published: December 2021

El impacto productivo de los nematodos gastrointestinales (NGI) sobre los de pequeños rumiantes es conocido a nivel mundial. Las infestaciones por NGI constituyen una limitante de alto impacto en la producción de rumiantes y las perdidas comprendidas por este problema sanitario varían desde reducciones subclínicas en la ganancia de peso hasta  la muerte de animales con altas cargas parasitarias. El objetivo de este trabajo es presentar los resultados de un test de eficacia a campo utilizando una combinación comercial de Abamectina + Derquantel  y del Moxidectin en cabras lecheras naturalmente infestadas con NGI en el Valle de Lerma, provincia de Salta. El ensayo se llevó a cabo en la Unidad Tambo Caprino de la Estación Experimental Agropecuaria Salta del INTA. Para la evaluación de eficacia de la droga en estudio, se realizó el test de reducción de conteos de huevos. En los coprocultivos pre-tratamientos se pudo observar una gran prevalencia de Trichostrongylus spp. (71%). seguido de Teladorsagia spp. (21%) y Haemonchus spp. (8%). En cuanto a los resultados del TRCH, en el GDQ se observaron valores del 100% de PRCH, mientras que en el GMX se observó un PRCH de 95,5 %, donde la eficacia para Haemonchus spp. y Teladorsagia spp. fue del 100% y para Trichostrongylus spp. del 81,1%.Los resultados observados en este trabajo permiten concluir que en las condiciones de campo en donde fue llevado a cabo el TRCH, la combinación Derquantel-Abamectina posee una alta eficacia contra los géneros presentes
A case of vitiligo regression in a patient with psoriasis and psoriatic arthritis receiving adalimumab therapy
Authors: Rudneva N. S. , Natarova E. V. , Sorotskaya V. N. , Sadunashvili T. G.
Published: December 2021

The article discusses the common pathogenetic pathways of autoimmune skin diseases – psoriasis and vitiligo. Currently proposed treatments for vitiligo do not significantly reduce or completely restore skin pigmentation. The use of adalimumab for 6 years in a patient suffering from psoriasis, psoriatic arthritis (PsA), vitiligo and autoimmune thyroiditis made it possible to control the activity of psoriasis and PsA, and also contributed to the regression of depigmentation foci. The use of biologic disease-modifying antirheumatic drug therapy in this group of patients in order to achieve repigmentation may be promising.
Objective assessment of the damaging effect of glucocorticoids (toxicity index) in patients with systemic lupus erythematosus
Authors: Nikishina N. Yu. , Ermolaeva E. V. , Mesnyankina A. A. , Aseeva E. A. , Soloviev S. K. , Isaeva B. Sh. , Koylubaeva G. M. , Lila A. M.
Published: December 2021

Systemic lupus erythematosus (SLE) is a multisystem disease characterized by chronic inflammation and damage to vital organs and systems. Despite the great success achieved in the treatment of SLE, glucocorticoids (GC) remain one of the main methods of therapy. The GC toxicity index is an objective method for assessing adverse events associated with their use, and in future studies can be actively used to monitor the safety of various therapy regimens. Wider introduction of this index in the management of patients with SLE will allow to optimize approaches to the selection of GC doses, to consider earlier prescription of biologic disease modifying antirheumatic drugs, before the development of severe irreversible damage.
Role of fatty acids in inflammation, atherosclerosis, metabolic disorders and gout
Authors: Gromova M. A. , Tsurko V. V. , Kislyak O. A. , Kiseleva E. V.
Published: December 2021

Fatty acids (FA) are present in all types of organisms and play an important role in energy metabolism. The length and number of double bonds in the FA of membrane phospholipids determine the viscosity, the activity of transport systems and enzymes, and also the susceptibility to lipid peroxidation. The review discusses the influence of free unsaturated FAs with short and long chains on various inflammatory mechanisms, including atherosclerosis. It has been shown that FAs can reduce endothelial activation and affect the metabolism of eicosanoids. A new model of fundamental factors determining the variability of the timing, degree and duration of acute inflammatory reactions in the deposition of urate crystals in tissues, in which FAs play an important role is considered, using gout as an example. In the future, the study of FAs will expand the understanding of the pathophysiology of chronic inflammation in various diseases, metabolic disorders and atherosclerosis and enable the development of new treatment strategies.
Serum amyloid A as a marker of ankylosing spondylitis activity
Authors: Sakharova K. V. , Cherkasova M. V. , Erdes Sh. F.
Published: December 2021

Serum amyloid A protein A (SAA) is a normal serum protein (serving as a precursor of fibrillar tissue protein AA), synthesized in the liver and a rapidly responding marker of the acute phase of inflammation. A constant high concentration of SAA is one of the factors in the development of AA-amyloidosis. As a rule, secondary amyloidosis develops in patients with long-term and poorly controlled inflammatory diseases, including rheumatic diseases, one of which is ankylosing spondylitis (AS).

Objective: to assess the level of SAA in AS patients and its relationship with indicators of disease activity.

Patients and methods. The study included 124 patients with AS who met the modified New York 1984 criteria. The disease activity and functional status of patients were assessed according to the recommendations of Russian experts. SAA and CRP, ESR in blood serum were measured in all patients.

Results and discussion. The median SAA concentration was 12.5 mg/L [4; 71.6]. Of 124 patients, 31% had SAA levels <5 mg/L and 69% had >5 mg/L. A strong correlation was found between the levels of SAA and CRP (r=0.80, p<0.000001), no significant relationship was found between SAA and ESR (r=0.31, p=0.92). The correlation between the AS activity according to the BASDAI index and SAA was weak (r=0.3, p<0.002), the correlation with ASDAS-CRP was moderate (r=0.54, p<0.00001).

Conclusion. A statistically significant relationship was found between SAA and CRP levels, as well as the AS activity indices. Research has shown that SAA can be used as one of the markers of inflammation in AS.
Long-term use of nonsteroidal anti-inflammatory drugs for pain control in patients with osteoarthritis: results of the 12-month observational study AELITA (Analgesia: Effective Treatment Using The Therapeutic Algorithm)
Authors: Karateev A. E. , Polishchuk E. Yu. , Filatova E. S. , Potapova A. S. , Nesterenko V. A. , Amirdzhanova V. N.
Published: December 2021

Non-steroidal anti-inflammatory drugs (NSAIDs) are the primary means of managing chronic osteoarthritis (OA) pain. The choice of NSAIDs is based on an analysis of the risk of adverse reactions (ARs). Objective: to evaluate the efficacy and safety of long-term use of NSAIDs for pain control in patients with OA in real clinical practice.

Patients and methods. To assess the results of long-term use of NSAIDs in OA, a 12-month observational non-interventional study was conducted. It included 611 patients with knee, hip and generalized OA, and nonspecific back pain associated with OA of the facet joints. All patients were prescribed aceclofenac (Aertal®) 200 mg/day. The patients' condition was assessed 2 weeks, 3, 6, 9 and 12 months after the start of therapy. The following parameters were determined: the intensity of pain during movement and the general health assessment (GA) according to the visual analogue scale (VAS, 10 cm); pain intensity according to the Likert verbal rating scale (VRS) (0–4); the number of patients with a pain reduction of ≥50% from baseline; patients' assessment of the result of therapy according to Likert VRS (1–5). The development of ARs was recorded at each visit.

Results and discussion. By month 12, 46.8% of patients had dropped out of observation. In patients who continued the study, the average severity of pain according to the VAS at baseline, after 2 weeks, 3, 6, 9 and 12 months was: 6.5±1.2; 4.8±1.4; 3.2±1.4; 2.6±1.4; 2.2±1.1; 1.4±1.1 cm, respectively (significant differences compared to the baseline for all points – p<0.05). The same differences were obtained in GA assessment.

Within the indicated time frame, the number of patients with moderate / severe pain (on the Likert scale) decreased from 77.8 to 24.9; 2.9; 2.3; 0.9 and 0%, respectively. The number of patients with a pain reduction of ≥50% from baseline was 12.0; 65.1; 81.0; 88.5 and 84.0%, respectively. A good or excellent assessment of treatment results after 2 weeks was given by 63.3% of patients, and after 12 months – by 95.6%. ARs were observed in about 30% of patients, mainly mild or moderate dyspepsia (in 11.1–23.3%) and arterial hypertension (in 7.1–10.9%). No serious ARs were registered.

Conclusion. Aceclofenac is an effective and relatively safe drug for the long-term management of chronic pain in OA.
Meloxicam efficacy and safety in treatment of pain syndromes of different localization according to domestic studies
Authors: Shavlovskaya O. A. , Bokova I. A. , Shavlovskiy N. I.
Published: December 2021

More than 500 million people worldwide suffer from osteoarthritis (OA). Neck and low back pain (LBP) is one of the most common reasons for visiting a general practitioner to receive primary medical care in different countries. The prevalence of chronic LBP varies from 4% to 20%, and increases linearly from the third decade to 60 years, and stabilizes in the seventh decade of life. According to the latest published clinical guidelines of the Russian Association for the Study of Pain, nonsteroidal anti-inflammatory drugs (NSAIDs) are used in minimally effective doses and a short course to relieve acute musculoskeletal pain. The ratio of the NSAIDs activity associated with cyclooxygenase (COX) – COX-1 / COX-2 – inhibition allows us to evaluate their potential toxicity. The smaller this value, the more selective the drug is against COX-2, and the less toxic it is. Meloxicam belongs to the predominantly selective COX-2 inhibitors. In the Russian market, meloxicam of domestic production - Amelotex® is widely prescribed. Several studies have shown the high efficacy and safety of meloxicam in the treatment of pain syndromes with different localizations (LBP, neck pain of vertebrogenic nature, OA, etc.), it can be recommended for elderly patients, patients with comorbid diseases such as arterial hypertension (AH), diabetes mellitus, gastrointestinal tract pathology. Meloxicam has a good efficacy and safety profile, a pronounced symptom-modifying effect.
Adaptation and Psychometric Properties of the Self Report Emotional Intelligence Test (SSEIT) among Brazilian athletes
Authors: Ferreira Lima Karlla Emanuelle , Freire Gabriel Lucas Morais , Sousa Vinicius da Cruz , Contreira Andressa Ribeiro , Moraes José Fernando Vila Nova de , Nascimento Junior José Roberto Andrade do
Published: December 2021

Emotional intelligence (EI) is a psychological skill that aids athletes in the control of emotions and optimization of sports performance. The present study investigated the psychometric properties of the Self-Report Emotional Intelligence Test (SSEIT) in 508 Brazilian youth and adult athletes (mean age 18.55±4.68 years). Data analysis was conducted through Exploratory (EFA) and Confirmatory (CFA) Factor Analysis, Cronbach’s alpha, composite reliability and Pearson’s Correlation (p <.05). EFA revealed the one-factor model with 26 items with the best adjustment. CFA confirmed the one-factor model with 26 items with best greater fit. No evidence of invariance was found, suggesting that the SSEIT must be used with caution when comparing gender and age groups. The external validity was found in the correlation of EI and cognitive anxiety and self-confidence. It is concluded that the Brazilian version of SSEIT for the sports context presented acceptable psychometric properties, however, showed limitations that should be explored in the future.
Muzeum Archidiecezjalne w Poznaniu na przełomie wieków XX i XXI
Authors: Pudelska Aleksandra
Published: December 2021

Przypadające w bliskim odstępie czasu trzy rocznice (powołania Akademii Lubrańskiego w 1518 r., założenia Muzeum Archidiecezjalnego w 1898 r., zakończenia modernizacji Muzeum we wrześniu 2007 r.) stwarzają Muzeum Archidiecezjalnemu w Poznaniu okazję do krytycznego spojrzenia na jego kondycję i działalność w minionym czasie. W tym artykule skupiono się na okresie drugiej połowy XX wieku i pierwszych dekadach wieku XXI. Zwrócono uwagę na ważny moment usamodzielnienia się placówki poprzez oddzielenie od istniejącego do tej pory łącznie Archiwum i Muzeum oraz powołanie odrębnego dyrektora, któremu powierzono przede wszystkim zorganizowanie muzealnej ekspozycji i opiekę konserwatorską nad zabytkami całej archidiecezji. Zadania te zostały wykonane, co zapoczątkowało dobry okres działalności Muzeum – funkcjonowała otwarta dla publiczności ekspozycja z wystawą stałą i zmieniającymi się wystawami czasowymi, otwarto nowy oddział, dobrze prosperowała pracownia konserwatorska. Zmiany ustrojowe, wejście Polski do wspólnoty Unii Europejskiej oraz objęcie rządów w archidiecezji przez nowego arcybiskupa stworzyły nowe możliwości działania dla Muzeum. W tej chwili Muzeum Archidiecezjalne w Poznaniu to licząca się w mieście placówka kulturalna współpracująca z wieloma instytucjami nauki i kultury, z bogatym programem edukacyjnym dla dzieci i młodzieży oraz wartościową ofertą kulturalną dla każdego.
Naughty Girl, or Not a Girl? Behavior and Becoming in Les Malheurs de Sophie
Authors: Mangerson Polly T.
Published: December 2021

This study presents a critical analysis of the classic nineteenth-century French children’s novel Les Malheurs de Sophie, written by the Comtesse de Ségur. The story follows the misadventures of a mischievous little girl in order to highlight the consequences of her naughty behavior and provide a counter-example for Ségur’s young female readers. In this article, Mangerson draws upon scholarship in both queer theory and early childhood psychology to demonstrate that Sophie’s inappropriate behavior can be interpreted by the modern reader as evidence of gender fluidity. Mangerson examines Sophie’s misuse of gender-specific toys, her curiosity to explore forbidden spaces, and her failure to conform to her peers. This study argues that this “naughty girl” is perhaps “not a girl,” and that her behavior is indicative of the process of gender identity formation, which is strongly influenced by socio-historical constructs of femininity.
Brain imaging genomics: influences of genomic variability on the structure and function of the human brain
Authors: Mühleisen Thomas W. , Forstner Andreas J. , Hoffmann Per , Cichon Sven
Published: December 2021

Brain imaging genomics is an emerging discipline in which genomic and brain imaging data are integrated in order to elucidate the molecular mechanisms that underly brain phenotypes and diseases, including neuropsychiatric disorders. As with all genetic analyses of complex traits and diseases, brain imaging genomics has evolved from small, individual candidate gene investigations towards large, collaborative genome-wide association studies. Recent investigations, mostly population-based, have studied well-powered cohorts comprising tens of thousands of individuals and identified multiple robust associations of single-nucleotide polymorphisms and copy number variants with structural and functional brain phenotypes. Such systematic genomic screens of millions of genetic variants have generated initial insights into the genetic architecture of brain phenotypes and demonstrated that their etiology is polygenic in nature, involving multiple common variants with small effect sizes and rare variants with larger effect sizes. Ongoing international collaborative initiatives are now working to obtain a more complete picture of the underlying biology. As in other complex phenotypes, novel approaches – such as gene–gene interaction, gene–environment interaction, and epigenetic analyses – are being implemented in order to investigate their contribution to the observed phenotypic variability. An important consideration for future research will be the translation of brain imaging genomics findings into clinical practice.
Spinal muscular atrophy (5qSMA): best practice of diagnostics, newborn screening and therapy
Authors: Eggermann Katja , Gläser Dieter , Abicht Angela , Wirth Brunhilde
Published: December 2021

Proximal spinal muscular atrophy (SMA) is an autosomal-recessive inherited neuromuscular disorder caused by the degeneration of alpha motor neurons in the anterior horn of the spinal cord. Patients show hypotonia, muscular atrophy and weakness of voluntary proximal muscles. SMA is one of the most common genetic diseases, with a frequency of about 1 in 7,000 newborns in Germany. The vast majority of patients carry a homozygous deletion of exons 7 and 8 of the survival motor neuron (SMN) 1 gene on chromosome 5q13.2; only about 3–4 % of patients are compound heterozygous for this common mutation and an additional subtle mutation inSMN1. The severity of the disease is mainly influenced by the copy number of the highly homologousSMN2.

Since the discovery of the underlying genetic defect 25 years ago, both the diagnostics of SMA and its treatment have undergone constant and in recent times rapid improvements. SMA has become one of the first neuromuscular disorders with effective therapies based on gene targeted strategies such as splice correction ofSMN2via antisense oligonucleotides or small molecules or gene replacement therapy with a self-complementary adeno-associated virus 9 expressing theSMN1-cDNA. With the availability of treatment options, which are most effective when therapy starts at a pre-symptomatic stage, a newborn screening is indispensable and about to be introduced in Germany. New challenges for diagnostic labs as well as for genetic counsellors are inevitable.

This article aims at summarising the current state of SMA diagnostics, treatment and perspectives for this disorder and offering best practice testing guidelines to diagnostic labs.
A perspective on human cell models for POLG-spectrum disorders: advantages and disadvantages of CRISPR-Cas-based vs. patient-derived iPSC models
Authors: Cakmak Cagla , Zempel Hans
Published: December 2021

Neurogenetic diseases represent a broad group of diseases with variable genetic causes and clinical manifestations. Among these, polymerase-gamma (POLG)-spectrum disorders are relatively frequent with an estimated disease frequency of ∼1:10.000. Also, mutations in the POLG gene are by far the most important cause for mitochondriopathy. POLG-spectrum disorders usually result in progressive loss of brain function and may involve severe and deadly encephalopathy, seizures, and neuromuscular disease, as well as cardiac and hepatic failure in some cases. Onset of disease may range from birth to late adulthood, and disease duration ranges from weeks in severe cases to decades. There is no curative treatment; current animal models do not faithfully recapitulate human disease, complicating preclinical therapeutic studies. Human-based preclinical model systems must be developed to understand the human disease mechanisms and develop therapeutic approaches. In this review, we provide an overview of the current approaches to model neurogenetic disorders in a human cellular and neuronal environment with a focus on POLG-spectrum disorders. We discuss the necessity of using neuronal cells and the advantages and pitfalls of currently available cell model approaches, namely (i) CRISPR-based (i. e., genetically engineered) and induced pluripotent stem cell (iPSC) (i. e., stem cell like)-derived neuronal models and (ii) the reprogramming of patient-derived cells into iPSCs and derived neurons. Despite the fact that cell models are by definition in vitro systems incapable of recapitulating all aspects of human disease, they are still the reasonable point of start to discover disease mechanisms and develop therapeutic approaches to treat neurogenetic diseases.
Overview of Kenyan Government Initiatives in Slum Upgrading: The Case of KENSUP and KISIP Projects
Authors: Solymári Dániel , Mangera Janet , Czirják Ráhel , Tarrósy István
Published: December 2021

The goal of this paper is to explore the slum upgrading processes: the implementation of the Kenyan KENSUP project, associated successes and failures, and to draw possible lessons that can be learned from the initiative. The study utilized field work desk reviews to gather relevant information regarding slum upgrade processes in Kenya. The criteria used in the review process entailed exploring the context in which the KENSUP upgrading project was implemented, focusing on the legal frameworks, process of implementation, achievements, results, setbacks and failures in the processes in order to draw lessons for future programmes.
Antropološka prolegomena i Filozofijski fragmenti “nulte godine”
Authors: Matošević Andrea
Published: December 2021

U radu se analiziraju dodirne točke, teme zajedničke knjigama Dijalektika prosvjetiteljstva: filozofijski fragmenti Maxa Horkheimera i
Theodora Adorna i Magični svijet: prolegomena jednoj priči magizma Ernesta De Martina. Upravo jer su objavljene u poratnom periodu, i to u razmaku od samo godine dana, 1947. odnosno 1948. godine, njih će, među ostalim publikacijama, talijanski povjesničar Carlo Ginzburg imenovati i
smjestiti među knjige “nulte godine”. Iako se radi o filozofskom i antropološkom djelu, među njima postoje tematska preklapanja, no među njihovim autorima neće ni u budućim publikacijama doći do značajnijeg međusobnog uzimanja u obzir. Teme koje su im bliske, ali istovremeno i različito artikulirane jesu mit, magija, prosvjetiteljstvo i modernitet te se sadržajni paralelizam tih izrazito utjecajnih djela u ovome radu prepleće u jednu srodnu, ali ne odveć čvrsto povezanu cjelinu. Pored isticanja komplementarnosti rezultata do kojih su došli u teorijskim i empirijskim istraživanjima, u radu se uzima u obzir i publikacija Alfreda Sohn-Rethela koja im prethodi, te se smješta u suodnos s njihovim djelima.
Readings Behind the Early Christian Queer Experiences
Authors: Orlov Vilimonović Larisa
Published: December 2021

This paper deals with the ideas of queer experiences in the Early Christian movement, seen through early Christian epistemologies of gender and patristic thought focused on sex differences. The lives and passions of transgender nuns are used in discussing various aspects of gender fluidity in early Christianity. Theoretically, the paper rests on
the idea of the performativity of gender, that is, on the ways gender was constructed and how body modifications enabled renegotiation of gender categories. It also focuses on the social context of queer experiences in the late antique period with regard to Roman social norms.
Robo2 Drives Target-Selective Peripheral Nerve Regeneration in Response to Glia-Derived Signals
Authors: Murphy Patricia L. , Isaacman-Beck Jesse , Granato Michael
Published: December 2021

Peripheral nerves are divided into multiple branches leading to divergent synaptic targets. This poses a remarkable challenge for regenerating axons as they select their original trajectory at nerve branch-points. Despite implications for functional regeneration, the molecular mechanisms underlying target selectivity are not well characterized.Danio Rerio(zebrafish) motor nerves are composed of a ventral and a dorsal branch that diverge at a choice-point, and we have previously shown that regenerating axons faithfully select their original branch and targets. Here we identifyrobo2as a key regulator of target-selective regeneration (sex of experimental subjects unknown). We demonstrate thatrobo2function in regenerating axons is required and sufficient to drive target-selective regeneration, and thatrobo2acts in response to glia located precisely where regenerating axons select the branch-specific trajectory to prevent and correct axonal errors. Combined, our results reveal a glia-derived mechanism that acts locally via axonalrobo2to promote target-selective regeneration.

SIGNIFICANCE STATEMENTDespite its relevance for functional recovery, the molecular mechanisms that direct regenerating peripheral nerve axons toward their original targets are not well defined. Zebrafish spinal motor nerves are composed of a dorsal and a ventral branch that diverge at a stereotyped nerve branch-point, providing a unique opportunity to decipher the molecular mechanisms critical for target-selective regeneration. Using a combination of live cell imaging and molecular-genetic manipulations, we demonstrate that therobo2guidance receptor is necessary and sufficient to promote target-selective regeneration. Moreover, we demonstrate thatrobo2is part of a genetic pathway that generates transient, spatially restricted, and tightly coordinated signaling events that direct axons of the dorsal nerve branch toward their original, pre-injury targets.
A Survey on Women's Motivation to Reduce Poverty
Authors: Pitaloka Lola Kurnia , Setiawan Avi Budi , Alfianti Ririn
Published: December 2021

Nowadays, women still become an objectsof life. Even though women can be competent objects of development. Lack of motivation to women is the main problem why women are not productive in public matters. The purpose of this study was to see whether women's empowerment could increase women's motivation to alleviate poverty. This research is an exploratory research which intends to collect facts in depth. The population in this study were 229 women from poor communities who did not or had not worked in Kudus Regency. The sample obtained from Slovin formula is 145 women with the sampling technique using random sampling. Data were collected using a questionnaire and analyzed using SEM with the warpPLS analysis tool. This research shows that the motivation of the population of women does indeed have a significant effect on poverty alleviation because motivation makes what women do to be unbiased. Empowerment of women does not have any effect on motivation for poverty alleviation.
The Obstacles in Developing MSMEs in The District of Jagoi Babang
Authors: Budiman Jumardi , Herkulana Herkulana
Published: December 2021

The aim of this research was to identify the obstacles in developing MSMEs in the district of Jagoi Babang. The approach used in this research was descriptive qualitative in which the instruments of data collecting were interview, observation sheets, and documentary study. The sources of data in this research were 16 (sixteen) Bidai craftsmen, the stakeholders from the Department of Cooperative, SME, Labour and Transmigration that represented by the chief of development section of MSMEs. The techniques of data analysis were data reduction, data display and conclusion drawing or verification. The findings of the study showed that the obstacles in developing MSMEs on Bidai craft in Jagoi Babang, Bengkayang regency, were the entrepreneurs did not have business license, facing difficulties in accessing the capital aid, lack of managerial competence, lack in using the modern technology in the production and marketing process that impacted to the turnover and the profit could not be increased.
Energy Efficiency: The Manufacturing Sector in Indonesia
Authors: Hariyanto Bayu
Published: December 2021

Indonesia is involved in the global effort to alleviate the deterioration of the environment due to climate change. Given that the manufacturing industry accounts for the second-highest share of national energy consumption, efficiency energy in the industrial sector is crucial. This research examines which industrial subsector has to be prioritized to improve energy efficiency and what are the determinant factors that influence energy efficiency in Indonesia manufacturing. This study analyzes energy intensity as an approach to measure energy efficiency. Focusing on the 2010 - 2015 period, this research employs two methods, namely input-output and panel data regression analysis. The empirical finding shows that textiles and textile products; pulp, paper, paper products, printing, and publishing; and rubber and plastics sectors are the first priority subsectors that must implement green industry standards. The next priority is the subsectors at the second level but have no green industrial standards, namely electrical and optical equipment. Furthermore, there were four variables that statistically increase energy intensity, namely lagged energy intensity, technology intensity, lagged value added, and location of plant. However, other two variables, the price of electricity and company size, can reduce energy intensity.
Pandemic Impact of Covid-19 on Social - Economic Conditions in West Sumatera
Authors: Suryani Yosi , Rinaldy Rudy
Published: December 2021

This study aims to determine and analyze the impact of Covid-19 pandemic in terms of socio-economy based on the demographic characteristics of the people in West Sumatra. The data collection method is secondary data, namely data from West Sumatra Provincial BPS and Padang City BPS 2020. Data processing is descriptive quantitative. The discussion of the research analysis is explained in depth and the interpretation of the data is presented in a straightforward and detailed manner in order to produce conclusions containing short answers to the formulation of the problem based on the data that has been collected. The results of the study concluded that there were changes in the socio-economic conditions of the people of West Sumatra according to demographic characteristics due to the Covid-19 pandemic, including the emergence of new habits, workers being temporarily laid off, using restricted public transportation, implementing WFH at work, the service sector being the most affected. As a result of Covid-19, workers in the Wholesale and Retail Trade, Car and Motorcycle Repair, Transportation and Warehousing sectors, as well as the Accommodation and Food and Drink Provision sectors were the most affected, increasing spending and decreasing income.