bluuebunny/crossref_metadata_2025 huggingface dataset:
Dijital Reklamlarda Yaratıcı Mesaj Stratejisi: Youtube Reklamları Üzerine Bir Araştırma
Authors: Aycan Hazal
Published: December 2024

Hayatın her anında karşılaşılan reklam yoğunluğu içinde, yalnızca özgün tasarıma sahip, ilgi çekici ve diğerlerinden sıyrılarak öne çıkan reklamlar, tüketicilerin zihinlerinde yer edinebilmektedir. Yoğun rekabet ortamında, markaların kendilerini farklılaştırmak adına kullandıkları stratejilerden biri, Charles Frazer tarafından geliştirilen yaratıcı mesaj stratejisidir. Çalışmanın amacı, 2023 yılında YouTube Ad Leaderboards'ta yer alan reklamlar, Charles Frazer'ın yaratıcı mesaj stratejisi çerçevesinde analiz etmektir. Araştırma kapsamında, tüketicilerin en fazla ilgi gösterdiği ve etkileşimde bulunduğu reklamların hangi yaratıcı stratejilerle hazırlandığını tespit etmek hedeflenmiştir. Frazer’ın stratejisi, tüketicilerin dikkatini çekme ve marka algısını kalıcı bir şekilde etkileme konusundaki etkisiyle, diğer yaratıcı stratejilerden ayrışmaktadır. Araştırma, reklamların başarısının arkasındaki temel faktörleri anlamak ve bu stratejilerin tüketici üzerindeki etkisini değerlendirmek amacıyla gerçekleştirilmiştir. Böylece, yaratıcı mesaj stratejilerinin dijital reklamcılık alanındaki rolü ve önemi hakkında daha derinlemesine bir içgörü sağlanması amaçlanmıştır. Çalışmada, nitel araştırma yöntemlerinden içerik analizi kullanılmış ve kodlama cetveline göre inceleme yapılmıştır. Kodlama cetveli; ürün kategorisi, mesaj stratejisi, ton, hedef kitle ve reklam türü olmak üzere beş ana unsurdan oluşmaktadır. Araştırmanın örneklemi, 2023 YouTube Ad Leaderboards'ta yer alan 37 reklamdan meydana gelmektedir. Elde edilen bulgulara göre, reklamlarda en sık kullanılan ürün kategorisi gıda olmuştur. Mesaj stratejisi bağlamında, reklamlarda en fazla marka imajı stratejisi tercih edilmiştir. Ton kullanımı açısından, reklamların büyük çoğunluğunda gerçekçi ton kullanıldığı görülmüştür. Hedef kitle analizi, hem kadınları hem erkekleri kapsayan bir yaklaşımın benimsendiğini ortaya koymuştur. Reklam türlerine ilişkin değerlendirmede ise en fazla ürün/hizmet reklamları kullanıldığı sonucuna ulaşılmıştır.
KÜLTÜREL FARKLILIKLARIN MARKA İLETİŞİMİNE ETKİSİ: COCA-COLA ÖRNEĞİ ÜZERİNE BİR İNCELEME
Authors: Solak Bahadır Burak
Published: December 2024

Bu çalışmada, kültür ve kültürel farklılıkların global markaların iletişim stratejilerine etkisi, Coca-Cola'nın Amerika Birleşik Devletleri ve Türkiye'deki "Tadını Çıkar" (Taste the Feeling) kampanyası üzerinden irdelenmektedir. Bu noktada aynı kampanya kapsamında iki ülkede kullanılan görsel içerikler temel alınmaktadır. Hofstede'nin kültürel boyutlar teorisi araştırmanın kuramsal altyapısını oluşturmaktadır. Teorinin bireysellik ve kolektivizm boyutu ekseninde, markanın kampanyada kullandığı görsel içeriklerin söz konusu iki ülkede nasıl farklılaştığı değerlendirilmektedir. Bu bağlamda, Coca-Cola'nın her iki ülkede aynı kampanya kapsamında paylaştığı görsel içerikler göstergebilimsel analiz yöntemiyle incelenmiştir. Bulgular, Amerika'da bireysellik ve özgürlük temalarının yoğun bir şekilde kullanıldığını, Türkiye'de ise aile ve birliktelik gibi anlatıların ön plana çıkarıldığını göstermektedir. Dolayısıyla, Amerika’daki görsel içerikte bireysel haz ve özgürlüğün sembolleri yoğun bir şekilde kullanılırken, Türkiye’de toplumsallık ve geleneksel kültürle ilgili unsurlara vurgu yapılmaktadır. Coca-Cola, bu stratejiyle glokalizasyon yaklaşımını benimseyerek, her iki ülkede yerel kültürel değerlere uyum sağlayan ancak global marka kimliğini koruyan bir reklam kampanyası yürütmüştür. Görsellerde kullanılan kırmızı ve beyaz renk paletleri gibi teknik unsurlar benzer olsa da semboller ve metaforlar kültürel farklılıkları güçlü bir şekilde yansıtmaktadır. Dolayısıyla bu araştırma glokalizasyon kavramı çerçevesinde, kültür ve kültürel farklılıkların marka iletişiminde nasıl etkili olduğunu ortaya koymaktadır.
Salmonella Prostatitis: A Review and Update
Authors:   North Manchester General Hospital, Department of Urology, Manchester M8 5RB, United Kingdom, Venyo Anthony Kodzo-Grey
Published: December 2024

Salmonella prostatitis is an extremely rare bacterial infection that has tended to be reported sporadically. There are many sub-types
of Salmonella bacteria. Salmonella infection is a common infection that tends to affect the gastrointestinal tract but on rare occasions
Salmonella infection does affect other organs. Some of the Salmonella species that had been isolated in some cases of Salmonella
prostatitis have included: Salmonella typhimurium, Salmonella St Paul, Salmonella enteritidis, Salmonella panama, and Salmonella
para-typhoid. Nevertheless, the common organisms that tend to be cultured in majority of cases of bacterial prostatitis tend to include:
Escherichia coli, Klebsiella spp, Proteus spp, Enterococci spp, and Pseudomonas. Manifestations of Salmonella prostatitis tend to be
non-specific that could include: fever. perineal pain / discomfort, suprapubic discomfort / pain, voiding difficulties, symptoms and signs
suggestive of urinary tract infection. There may or may not be a history of recent diarrhoea, homosexuality, or immunodeficiency or
spinal cord injury with voiding dysfunction and undertaking of clean intermittent self-urethral catheterisation.
Infectious Diarrhea, as Public Health Problem, in Romania
Authors:   National Public Health Institute, Public Health Center, Cluj- Napoca, Romania, Deac Liana Monica
Published: December 2024

“From medical point of view, “Diarrhea” is an alteration in a normal
bowel movement characterized by an increase in the water content,
volume, or frequency of stools. Acute diarrhea of infec¬tious etiology,
often referred to as gastroenteri¬tis and is typically associated with
clinical signs and symptoms including: nausea, vomiting, abdomi¬nal
pain and cramps, bloating, flatulence, fever, passage of bloody stools,
tenesmus, and fecal ur¬gency. Infectious diarrheal diseases are the
second leading cause of morbidity and mortality worldwide. It is the
diarrhea we have also found out, during a large 3 yeas study 2017-2020
in Transylvania – Romania. 3577 number of cases were transmitted
during this time, to our Public Health Center, by 12 district Sanitary
Polices. These were mostly diagnosed by the territorial family doctors
and more than 50%, have need hospitalization, for several days because
of the mentioned disease disorders. The detected infectious etiology,
were determined in authorized laboratories in which it was identified:
Shigella, Salmonella, Campylobacter, and Yersinia, Rotavirus, Giardia.
Most number of cases appeared in children, followed by elderly or
adult people, as quantified number of determination.
Impressionable of Bupivacaine at Pain Relief in Post-Operative Disc Herniation Surgery
Authors:   Professor assistant surgical Neurosurgery, faculty member of Department of Neurosurgery, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran, Shirazi Seyyed Mehran Molavi
Published: December 2024

there are many reports about the efficacy of analgesics in
reducing postoperative pain after disc herniation surgery. This study
aimed to investigate the effect of subdermal and intramuscular
injection of bupivacaine on the severity of postoperative pain relief
disc herniation.
Obowiązki przedsiębiorców telekomunikacyjnych w zakresie cyberbezpieczeństwa
Authors:   Uniwersytet Warszawski, Wydział Zarządzania, Katedra Prawnych Problemów Administracji i Zarządzania, Piątek Stanisław
Published: December 2024

W artykule przedstawiono status przedsiębiorców telekomunikacyjnych w sprawach dotyczących cyberbezpieczeństwa z uwzględnieniem przepisów Unii Europejskiej i przepisów krajowych. Mimo wyłączenia przedsiębiorców telekomunikacyjnych z zakresu stosowania ogólnych przepisów o cyberbezpieczeństwie, podmioty te są w ramach regulacji sektorowej zobowiązane do realizacji obowiązków zabezpieczającymi sieci, usługi i komunikaty przed zagrożeniami, eliminowania tych zagrożeń oraz informowania użytkowników usług i organów państwowych o występujących zagrożeniach. Prezes UKE zapewnia przepływ informacji o incydentach w sektorze telekomunikacyjnym do właściwych organów w krajowym systemie cyberbezpieczeństwa.
Odpowiedzialność dostawcy usług cyfrowych w Krajowym Systemie Cyberbezpieczeństwa
Authors:   Ministerstwo Cyfryzacji, Proć Tomasz
Published: December 2024

W artykule autor przedstawia zagadnienie odpowiedzialności dostawców usług cyfrowych za naruszenie zasad cyberbezpieczeństwa. Omówione zostały obowiązki dostawców usług cyfrowych wynikające z przepisów ustawy o krajowym systemie cyberbezpieczeństwa w kontekście ochrony użytkowników oraz sankcje, jakie grożą dostawcom usług cyfrowych na gruncie tej regulacji. Poruszona została kwestia ochrony użytkowników usług cyfrowych z perspektywy przepisów ochrony danych osobowych oraz sankcje wynikające z tych regulacji. Autor analizuje również szczególną odpowiedzialność dostawców usług cyfrowych względem konsumentów.
Jean Langevin : une trajectoire (a)typique
Authors: Croft Marie-Ange , Thuot Jean-René
Published: December 2024

Premier évêque de Rimouski, Jean-Pierre-François-Laforce Langevin (1821-1892) connaît un parcours aussi représentatif qu’exceptionnel. Cet article introduit le dossier qui lui est consacré. Il met en perspective la trajectoire de cet homme d’Église ultramontain, en s’intéressant à ses premières années à Québec, où il se consacre à l’enseignement et à l’écriture, jusqu’à sa mort à Rimouski, après 25 ans à la tête de l’évêché. Il fait aussi valoir les conflits qui émaillèrent la carrière de l’évêque, et les mémoires contrastées qu’il a laissées à la postérité.
L’ascendance familiale de Jean Langevin : petite histoire des réseaux de pouvoir dans la colonie laurentienne, 1650‑1850
Authors: Thuot Jean-René
Published: December 2024

Les chroniqueurs et les historiens ayant fait état du parcours de l’évêque Jean Langevin ont tous souligné son talent politique indéniable, l’étendue de ses réseaux et l’importance de ses réalisations à la tête du diocèse rimouskois. Aucun n’a toutefois fait état du bagage familial de Jean Langevin, qui éclaire pourtant la trajectoire de l’évêque et de sa famille. Le portrait de son ascendance familiale offre une incursion au sein des réseaux de pouvoir de la colonie laurentienne et permet de saisir plus largement les contours d’une mémoire du pouvoir qui concourt à la formation de l’élite politique canadienne.
Le traité mathématique (1848) de Jean Langevin : origine, signification et portée
Authors: Simard Jean-Claude
Published: December 2024

Publié en 1848, le Traité élémentaire de calcul différentiel et de calcul intégral de Jean Langevin est un travail peu connu. Premier manuel canadien destiné à l’enseignement des mathématiques avancées, il n’avait jamais fait l’objet d’une analyse fouillée. Cette étude cherche à en déterminer les sources, la signification et la portée. Il importait de situer d’abord l’ouvrage dans le contexte de l’époque et dans le cadre du développement des mathématiques au Canada français. Le degré d’originalité de ce texte anonyme est ensuite évalué, avant que ne soit abordée la difficile question de son auditoire potentiel. Je conclus en notant sa faible postérité, car les années 1850 marquèrent un recul dans l’enseignement des sciences au Petit Séminaire de Québec, qui s’acheminait alors vers une forme d’orthodoxie philosophique et religieuse.
Antimicrobial peptides as new antibiotics: A comprehensive review
Authors: Thakur Amanpreet , Gupta Puja
Published: December 2024

Antibiotics have long been the foundation stone of combating infectious diseases, but the widespread and often indiscriminate use of these drugs has given rise to drug-resistant pathogens, presenting a global health crisis. There is an urgent need to explore alternative therapeutic strategies that are less susceptible to resistance mechanisms as traditional antibiotics are losing their efficiency. Antimicrobial peptides (AMPs), small bioactive proteins naturally produced by a wide range of organisms, have emerged as promising candidates in the search for new antibiotics. AMPs serve as the first line of defense against a broad spectrum of pathogens, including bacteria, viruses, and fungi. This review article looks into the wide potential of AMPs, not only as antibacterial agents but also in their roles as antifungal, antiviral, and anticancer therapies. The present review article provides an in-depth exploration of the structural diversity of AMPs, examining how their unique properties contribute to their broad-spectrum activity. It further discusses the mechanisms and modes of action that differentiate AMPs from conventional antibiotics. Despite their immense potential, several challenges such as toxicity, stability, and high production costs hinder the clinical application of AMPs. This article not only outlines these challenges but also discusses emerging strategies aimed at overcoming these barriers. Overall the review presents AMPs as a critical focus in the development of future antimicrobial therapies.
The impact of strategic management on organizational creativity and its influence on the financial performance of SMEs
Authors:   Faculty of Marketing and International Business, HUTECH University, No. 475A Dien Bien Phu st., Ward 25, Binh Thanh District, Ho Chi Minh City, Vietnam, e-mail: vk.tuan@hutech.edu.vn, Vuong Tuan Khanh
Published: December 2024

PURPOSE: This research intends to help small and medium-sized enterprises (SMEs) in Ho Chi Minh City (HCMC) to understand the strategic management process. The study considers an inside-and an outside-in perspective and the intermediary role of organizational creativity in financial performance. It also aims to help SMEs achieve financial performance benchmarks and work towards sustainable development goals. This research is also significant and adds value to the performance management domain. Its overarching objective is to promote long-term business expansion through an exploration of the strategic management process and how organizational creativity and financial performance can be supported. METHODOLOGY: The sample data are collected from 411 SMEs in HCMC using convenience sampling. The data are rigorously screened and cleaned to select a reliable sample for analysis, and Smart PLS software is employed for data analysis to achieve the study’s outcomes. FINDINGS: Factors such as the strategic management process, an inside-out perspective, an outside-in perspective, and the intermediary role of organizational creativity positively impact the financial performance of Vietnamese SMEs in HCMC. IMPLICATIONS: The results show that SMEs are making changes and influencing these factors to improve financial performance. This research contributes value and provides a holistic perspective on the strategic management process for Vietnamese SMEs in HCMC to improve financial performance. ORIGINALITY AND VALUE: The study offers insight into strategic management and highlights the pivotal role of creativity in managing the financial performance of enterprises. The overarching goal is to achieve sustainable development in an increasingly competitive environment. The study also provides a solid foundation for SME managers to restructure their operations for enhanced financial performance. It also offers valuable insights for future scholars to consider and apply in expanding available research models.
A neurotrophin functioning with a Toll regulates structural plasticity in a dopaminergic circuit
Authors: Sun Jun , Rojo-Cortés Francisca , Ulian-Benitez Suzana , Forero Manuel G , Li Guiyi , Singh Deepanshu , Wang Xiaocui , Cachero Sebastian , Moreira Marta , Kavanagh Dean , Jefferis Gregory , Croset Vincent , Hidalgo Alicia
Published: December 2024

Experience shapes the brain, as neural circuits can be modified by neural stimulation or the lack of it. The molecular mechanisms underlying structural circuit plasticity and how plasticity modifies behaviour, are poorly understood. Subjective experience requires dopamine, a neuromodulator that assigns a value to stimuli, and it also controls behaviour, including locomotion, learning and memory. In
Drosophila
, Toll receptors are ideally placed to translate experience into structural brain change.
Toll-6
is expressed in dopaminergic neurons (DANs), raising the intriguing possibility that Toll-6 could regulate structural plasticity in dopaminergic circuits.
Drosophila
neurotrophin-2 (DNT-2) is the ligand for Toll-6 and Kek-6, but whether it is required for circuit structural plasticity was unknown. Here, we show that
DNT-2
expressing neurons connect with DANs, and they modulate each other. Loss of function for
DNT-2
or its receptors
Toll-6
and kinase-less Trk-like
kek-6
caused DAN and synapse loss, impaired dendrite growth and connectivity, decreased synaptic sites and caused locomotion deficits. By contrast, over-expressed
DNT-2
increased DAN cell number, dendrite complexity and promoted synaptogenesis. Neuronal activity modified DNT-2, it increased synaptogenesis in DNT-2-positive neurons and DANs, and over-expression of DNT-2 did too. Altering the levels of DNT-2 or Toll-6 also modified dopamine-dependent behaviours, including locomotion and long-term memory. To conclude, a feedback loop involving dopamine and DNT-2 sculpted the circuits engaged, and DNT-2 with Toll-6 and Kek-6 induced structural plasticity in this circuit modifying brain function and behaviour.
Rab10 inactivation promotes AMPAR insertion and spine enlargement during long-term potentiation
Authors: Wang Jie , Nishiyama Jun , Parra-Bueno Paula , Okaz Elwy , Oz Goksu , Liu Xiaodan , Watabe Tetsuya , Suponitsky-Kroyter Irena , McGraw Timothy E , Szatmari Erzsebet M , Yasuda Ryohei
Published: December 2024

Rab-dependent membrane trafficking is critical for changing the structure and function of dendritic spines during synaptic plasticity. Here, we developed highly sensitive sensors to monitor Rab protein activity in single dendritic spines undergoing structural long-term potentiation (sLTP) in rodent organotypic hippocampal slices. During sLTP, Rab10 was persistently inactivated (>30 min) in the stimulated spines, whereas Rab4 was transiently activated over ∼5 min. Inhibiting or deleting Rab10 enhanced sLTP, electrophysiological LTP and AMPA receptor (AMPAR) insertion during sLTP. In contrast, disrupting Rab4 impaired sLTP only in the first few minutes, and decreased AMPAR insertion during sLTP. Thus, our results suggest that Rab10 and Rab4 oppositely regulate AMPAR trafficking during sLTP, and inactivation of Rab10 signaling facilitates the induction of LTP and associated spine structural plasticity.
Emergence of power law distributions in protein-protein interaction networks through study bias
Authors: Blumenthal David B , Lucchetta Marta , Kleist Linda , Fekete Sándor P , List Markus , Schaefer Martin H
Published: December 2024

Degree distributions in protein-protein interaction (PPI) networks are believed to follow a power law (PL). However, technical and study biases affect the experimental procedures for detecting PPIs. For instance, cancer-associated proteins have received disproportional attention. Moreover, bait proteins in large-scale experiments tend to have many false-positive interaction partners. Studying the degree distributions of thousands of PPI networks of controlled provenance, we address the question if PL distributions in observed PPI networks could be explained by these biases alone. Our findings are supported by mathematical models and extensive simulations, and indicate that study bias and technical bias suffice to produce the observed PL distribution. It is, hence, problematic to derive hypotheses about the topology of the true biological interactome from the PL distributions in observed PPI networks. Our study casts doubt on the use of the PL property of biological networks as a modeling assumption or quality criterion in network biology.
Effects of defeat and entrapment on suicide risk in university population: the role of rumination and sex
Authors: Silvestre Vidal Inmaculada Nayara , Nieto Marta , Ricarte Jorge , Vizcaíno Alcantud María Dolores , Hallford David , Ros Laura
Published: December 2024

Background

Suicide is recognized as a significant public health issue, with adolescents/young people being a risk group of concern. Taking the integrated motivational-volitional model as a reference, this study focuses on analyzing the association between defeat and entrapment, on the one hand, and suicide risk, on the other, in a university population without depressive symptoms, while also considering the role of rumination and sex.

Method

The survey study involved a community sample of 650 Spanish university students. A total of 524 students (150 men (Mage = 20.6, SD = 3.7) and 374 women (Mage = 20.4, SD = 3.6)) completed self-report measures of suicide risk, defeat, entrapment, and rumination.

Results

Defeat and entrapment were significantly associated with suicide risk, and higher rumination was both directly and indirectly associated with higher levels of entrapment through the variable of defeat. However, the effect of rumination on entrapment varied by sex.

Conclusion

Despite being a cross-sectional preliminary study, this work identifies important variables in the trajectory of suicidal ideation. Adolescence and young adulthood are a critical stage for intervening to reduce the risk of death by suicide, and this study provides findings that may inform preventive approaches.
Tem alguém aí? Um olhar integrativo sobre as ouvidorias dos Tribunais de Contas estaduais como ferramentas de coprodução
Authors: Resende Vanessa Reis Seixas , Lima Renata Santos , Carvalho Kleverton Melo de , Lima Alessandra Cabral Nogueira
Published: December 2024

Considerando que as Ouvidorias atuam diretamente na promoção da transparência passiva uma vez que oferecem ao cidadão um canal de comunicação com as instituições públicas, o objetivo deste estudo é realizar um olhar integrativo sobre o uso da coprodução no serviço público, notadamente no que se refere ao controle social exercido pela população por meio das Ouvidorias dos Tribunais de Contas Estaduais, entre os anos de 2020 e 2024. Para tanto, foi realizada uma pesquisa de caráter descritivo e abordagem qualitativa. O processo de seleção e exclusão contemplou 33 estudos, entre artigos científicos, teses, dissertações e trabalhos de conclusão de curso de graduação, entretanto, o presente estudo se debruçou na análise dos 7 artigos que demonstraram pertinência temática com o contexto da pesquisa. Desse modo, observa-se que as ouvidorias nos Tribunais de Contas brasileiros são instrumentos indispensáveis para a garantia da transparência e responsividade, os quais são conceitos intimamente associados ao dever de prestar contas por parte dos agentes públicos, o que permite concluir que funcionam como mecanismos de coprodução capazes de fomentar a eficiência das atividades no âmbito dos Tribunais de Contas brasileiros, sobretudo no que refere à transparência pública e ao controle social. A integração das Ouvidorias nas Cortes de Contas além de agregar ao controle social, ressignifica o papel da sociedade como protagonista na consolidação de uma gestão pública mais produtiva e participativa.
Learning Model of Writing Scientific Papers Based on Moodle Learning Management System, Indonesian Language Education Study Program, Pancasakti University of Makassar
Authors: Rusman  , Rapi Muhammad , Daeng Kembong
Published: December 2024

Aims: The development of information and communication technology at this time makes it easier to spread information to various regions, even information spreads quickly to all parts of the world. The latest information that occurs in an area can be obtained easily, so that the existence of information and communication technology today has helped the process of human life in carrying out daily activities. Likewise, with the world of education, the development of information technology has had an influence on the world of education, especially in the learning process.
Methodologhy: This study aims to find out how effective the learning model of writing scientific papers is. This type of research is a development research. In this study, there are four test subjects.
Results: The results of this study show that the learning of writing scientific papers in the Education Study Program Indonesian Pancasakti University of Makassar because the effectiveness criteria have been met, namely the t-value of calculation > the t-value of the table (9, 070 > 2.04).
Revealing Convenient Learning Practices and Professional Growth of Public Elementary School Teachers
Authors: Alega Geo P. , Baguio Josephine B.
Published: December 2024

This study described the revealing of convenient learning practices and professional growth of public elementary school teachers in Paquibato District, Division of Davao City. A non-experimental quantitative research design was used, employing a correlational method. The study involved 136 public elementary school teachers as respondents, selected through universal sampling. Data analysis included the use of mean, Pearson r, and regression analysis. The findings revealed that the degree to which teachers revealed convenient learning practices was moderate, as indicated by a mean score of 3.31, suggesting these practices were sometimes manifested. In contrast, the level of professional growth among teachers was high, with a mean score of 3.45, indicating that it was oftentimes demonstrated. Statistical analysis showed a significant relationship between the revealing of convenient learning practices and professional growth, with a p-value of 0.000. Additionally, the analysis found that the domains of convenient learning practices significantly influenced teachers' professional growth, as evidenced by an overall p-value of 0.000. Based on the findings, public school teachers may benefit from attending targeted conferences and training programs organized by the Department of Education (DepEd). These programs may focus on evidence-based teaching strategies, classroom management, and technology integration. Additionally, mentorship programs, peer collaborations, and workshops may help enhance teacher effectiveness. Regular assessments may track progress, provide feedback, and foster school-family partnerships to support student achievement.
Analysis of Right Ventricular Strain in Heart Failure with Preserved Ejection Fraction
Authors: ZTATI Mohamed , ZERHOUDI Rim , YAHYA Abdelkarim AIT , ELJAMILI Mohamed , ELHATTAOUI Mustapha
Published: December 2024

Introduction: The complexity of the geometry and the unique architecture of the right ventricular (RV) myocardial fibers make the study of its function a significant challenge. However, the advent of new imaging techniques, such as RV strain imaging, has improved our understanding of its function. The aim of our study is to specify the principles of studying right ventricular deformation and its impact on the prognosis of patients with heart failure with preserved ejection fraction (HFpEF).
Materials and Methods: This is a two-year prospective study comparing echocardiographic parameters of right ventricular function in 87 patients followed in our unit for HFpEF at the Cardiology Department of ERRAZI Hospital, CHU Mohammed VI, Marrakech.
Results: Over the past two years, our unit has hosted 87 patients diagnosed with HFpEF. The average age was 68 years and 5 months, with a female predominance. The most common cardiovascular risk factors were hypertension and obesity (BMI > 30). Symptomatic presentations were dominated by exertional dyspnea, observed in 84% of cases, with resting dyspnea and cough affecting about half of the patients. Signs of left heart failure, such as crackling rales, were present in 44% of patients, while signs of right heart failure, such as lower limb edema, were noted in 41%, with jugular distension and hepatojugular reflux in 19%. Echocardiography revealed left ventricular hypertrophy in 57% of patients and left atrial dilatation in 65%. Right ventricular function was markedly impaired, with significant abnormalities in TAPSE (Tricuspid Annular Plane Systolic Excursion), S' wave, and Tei index values, highlighting a marked correlation between the Tei index and the deformation of the right ventricular lateral wall. Rehospitalization for heart failure occurred in 40.2% of the cohort, emphasizing the severe clinical implications of right ventricular dysfunction in this patient population.
Discussion and Conclusion: RV strain in HFpEF is an analysis that has not yet revealed all its intricacies. This study demonstrates that there is an alteration in RV strain in patients with HFpEF, which has a prognostic impact on mortality and rehospitalization for cardiac decompensation. This suggests that this parameter should be integrated into routine evaluations of RV systolic function.
Varietal Evaluation of Tuberose for Commercial Traits
Authors: PM Hasna , M Rafeekher , I Priyakumari , CR Reshmi , Baby Greeshma , Manjusha AVM
Published: December 2024

Aims: To evaluate the tuberose varieties for growth, yield and smart farming application.
Study Design: The experiment was laid out in Randomized block design with three replications.
Place and Duration of Study: Department of Floriculture and Landscaping, College of Agriculture, Padannakkad, Kasargod during 2019-2020.
Methodology: Ten genotypes of tuberose viz. A. Shringar, A. Niranthara, A. Prajwal, A. Sugandhi, A. Suvasini, A. Vaibhav, Culcutta Single, Culcutta Double, Bidhan Ujwal and Phule Rajani were assessed for further evaluation in smart farming. Treatments were replicated thrice. The accessions were screened for vegetative, floral, quality and post-harvest parameters.
Results: The result of the study showed that out of the ten genotypes of tuberose A. Prajwal has been found suitable for commercial farming with highest plant height (54.27 cm), minimum days to 50% flowering (108.38 days), longest floret (6.97 cm), highest diameter of floret (3.53 cm), longest spike (111.80 cm), maximum yield per unit area (2125. 50 gm-2) and good aroma. Tuberose needs an improved package of practices for better yield in smart farming systems.
Conclusion: The genotype A. Prajwal was found superior for growth and yield characteristics and will, therefore, be considered for further research and development.
Effect of Artificial LED and Natural Light on the Growth of Cucumber Plant (Cucumis sativus) in Hydroponic System
Authors: Vibhute Kshitiy V. , Mohite Archana R.
Published: December 2024

Hydroponics is the latest innovation in farming where plants are grown in the absence of soil. In India adoption rate of hydroponics is estimated 13 – 15 % annually. In this context present study was conducted to analyze the morphological characteristics of cucumber plant in Dutch Bucket Hydroponic system. Moreover, comparative evaluation of morphological characteristics of cucumber plants were carried out under natural light as well as artificial light emitting diode (LED). The experiment was carried out in the Naturally Ventilated Polyhouse (NVPH) and in the laboratory (as an indoor practice) in the campus of Dadasaheb Mokashi Collage of Agricultural Engineering and Technology Rajmachi, Karad, Maharashtra, India. Cucumber (Cucumis sativus) HY shiny variety was grown in both the environments to evaluate different morphological characteristics such as average leaf count, leaf area, stem diameter, plant height and root length. Dutch bucket system of 10 buckets (each having capacity of 11 liters) was installed each in natural and artificial light source. Cucumber plants were grown in both environment for months June- July 2024. From the present experiment it was observed that, most of the selected parameters were found more satisfactory in artificial light as compared to natural light. Before the flowering stage, average leaf count, average leaf area, average plant height, and average root length was observed approximately 26, 123.15 cm2, 154 cm, 30.1 cm for artificial light and 22, 56.07 cm2, 110 cm, 25.3 cm for natural light, respectively. The average stem diameter was observed almost similar in both the systems and it was about 1.1 cm. Therefore, from this study it was envisaged that overall average leaf count, average leaf area, average plant height and average root length was improved in artificial light by 18%, 54%, 28%, and 25%, respectively over natural light.
A New Frontier of Printed Electronics: Flexible Hybrid Electronics
Authors: Khan Yasser , Thielens Arno , Muin Sifat , Ting Jonathan , Baumbauer Carol , Arias Ana C.
Published: November 2019

The performance and integration density of silicon integrated circuits (ICs) have progressed at an unprecedented pace in the past 60 years. While silicon ICs thrive at low‐power high‐performance computing, creating flexible and large‐area electronics using silicon remains a challenge. On the other hand, flexible and printed electronics use intrinsically flexible materials and printing techniques to manufacture compliant and large‐area electronics. Nonetheless, flexible electronics are not as efficient as silicon ICs for computation and signal communication. Flexible hybrid electronics (FHE) leverages the strengths of these two dissimilar technologies. It uses flexible and printed electronics where flexibility and scalability are required, i.e., for sensing and actuating, and silicon ICs for computation and communication purposes. Combining flexible electronics and silicon ICs yields a very powerful and versatile technology with a vast range of applications. Here, the fundamental building blocks of an FHE system, printed sensors and circuits, thinned silicon ICs, printed antennas, printed energy harvesting and storage modules, and printed displays, are discussed. Emerging application areas of FHE in wearable health, structural health, industrial, environmental, and agricultural sensing are reviewed. Overall, the recent progress, fabrication, application, and challenges, and an outlook, related to FHE are presented.
Pharmacokinetic studies of a novel tubulin inhibitor SK1326 in rat plasma by UPLC–MS/MS
Authors: Ji Young Seok , Kim Tae Kon
Published: November 2019

A sensitive method for quantitation of SK1326 in rat plasma has been established using ultra‐performance liquid chromatography–electrospray ionization tandem mass spectrometry (UPLC–ESI/MS/MS). SK1326 and the internal standard (tramadol) in plasma sample were extracted using acetonitrile. A centrifuged upper layer was then evaporated and reconstituted with a mobile phase of 0.5% formic acid–acetonitrile (35:65, v/v). The reconstituted samples were injected into a C18 reversed‐phase column. Using MS/MS in the multiple reaction monitoring mode, SK1326 and tramadol were detected without severe interference from the rat plasma matrix. SK1326 produced a protonated precursor ion ([M + H]+) at m/z 432.3 and a corresponding product ion at m/z 114.4. The internal standard produced a protonated precursor ion ([M + H]+) at m/z 264.4 and a corresponding product ion at m/z 58.1. Detection of SK1326 in rat plasma by the UPLC–ESI/MS/MS method was accurate and precise with a quantitation limit of 1.0 ng/mL. The validation, reproducibility, stability and recovery of the method were evaluated. The method has been successfully applied to pharmacokinetic studies of SK1326 in rat plasma. The pharmacokinetic parameters of SK1326 were evaluated after intravenous (at a dose of 10 mg/kg) and oral (at a dose of 20 mg/kg) administration of SK1326 in rats. After oral administration (20 mg/kg) of SK1326, the F (fraction absorbed) value was ~77.1%.
Soret and Dufour effects between two rectangular plane walls with heat source/sink
Authors: Ali Aamir , Iqbal F. , Khan Marwat D. N. , Asghar S. , Awais M.
Published: November 2019

This study addresses the thermo‐diffusion and the diffusion‐thermo phenomena in a semi‐infinite absorbent channel whose walls are contracting/expanding, with heat source/sink effects. The governing partial differential equations with suitable boundary conditions are transformed to a system of dimensionless ordinary differential equations. An analytic solution of the problem has been found using a technique called homotopy analysis method (HAM). HAM gives consistently valid answers to the problem over an extensive variety of parameters and also provides better accuracy. To validate the analytical results, a comparison has been presented with a numerical solution calculated by using the parallel shooting method. The effects of dimensionless parameters, that is, deformation parameter, Reynolds number, Soret and Dufour numbers, and heat source/sink parameter on the expressions of velocity, temperature, and concentration profiles are analyzed graphically to understand the physics of the deformable channel. It has been noted that the velocity across the channel is higher for the expanding channel, as compared to that for the contracting channel. Also the Soret and Dufour number increases the temperature of the fluid, and decreases the concentration. The temperature profile has an increasing behavior in the case of heat source, and a decreasing behavior in the case of heat sink.
The Accuracy of Prevalent Vertebral Fracture Detection in Children Using Targeted Case-Finding Approaches
Authors: Ma Jinhui , Siminoski Kerry , Wang Peiyao , Alos Nathalie , Cummings Elizabeth A , Feber Janusz , Halton Jacqueline , Ho Josephine , Houghton Kristin , Lang Bianca , Miettunen Paivi M , Scuccimarri Rosie , Jaremko Jacob L , Koujok Khaldoun , Lentle Brian , Matzinger Mary Ann , Shenouda Nazih , Rauch Frank , Ward Leanne M ,   and the Canadian Steroid-Induced Osteoporosis in the Pediatric Population (STOPP) Consortium
Published: November 2019

Due to concerns about cumulative radiation exposure in the pediatric population, it is not standard practice to perform spine radiographs in most conditions that predispose to vertebral fracture (VF). In this study we examined the accuracy of two clinical predictors, back pain and lumbar spine bone mineral density (LS BMD), to derive four case-finding paradigms for detection of prevalent VF (PVF). Subjects were 400 children at risk for PVF (leukemia 186, rheumatic disorders 135, nephrotic syndrome 79). Back pain was assessed by patient report, LS BMD was measured by dual-energy X-ray absorptiometry, and PVF were quantified on spine radiographs using the modified Genant semiquantitative method. Forty-four patients (11.0%) had PVF. Logistic regression analysis between LS BMD and PVF produced an odds ratio (OR) of 1.9 (95% confidence interval [CI], 1.5 to 2.5) per reduction in Z-score unit, an area under the receiver operating characteristic curve of 0.70 (95% CI, 0.60 to 0.79), and an optimal BMD Z-score cutoff of −1.6. Case identification using either low BMD alone (Z-score < −1.6) or back pain alone gave similar results for sensitivity (55%, 52%, respectively), specificity (78%, 81%, respectively), positive predictive value (PPV; 24%, 25%, respectively), and negative predictive value (NPV; 93%, 93%, respectively). The paradigm using low BMD plus back pain produced lower sensitivity (32%), higher specificity (96%), higher PPV (47%), and similar NPV (92%). The approach using low BMD or back pain had the highest sensitivity (75%), lowest specificity (64%), lowest PPV (20%), and highest NPV (95%). All paradigms had increased sensitivities for higher fracture grades. Our results show that BMD and back pain history can be used to identify children with the highest risk of PVF so that radiography can be used judiciously. The specific paradigm to be applied will depend on the expected PVF rate and the clinical approach to the use of radiography. © 2019 American Society for Bone and Mineral Research.
Pharmacodynamics of Metformin in Pregnant Women With Gestational Diabetes Mellitus and Nonpregnant Women With Type 2 Diabetes Mellitus
Authors: Shuster Diana L. , Shireman Laura M. , Ma Xiaosu , Shen Danny D. , Flood Nichols Shannon K. , Ahmed Mahmoud S. , Clark Shannon , Caritis Steve , Venkataramanan Raman , Haas David M. , Quinney Sara K. , Haneline Laura S. , Tita Alan T. , Manuck Tracy A. , Thummel Kenneth E. , Morris Brown Linda , Ren Zhaoxia , Brown Zane , Easterling Thomas R. , Hebert Mary F.
Published: November 2019

Gestational diabetes mellitus is a condition similar to type 2 diabetes mellitus (T2DM) in that patients are unable to compensate for the degree of insulin resistance, and both conditions are often treated with metformin. The comparative pharmacodynamic response to metformin in these 2 populations has not been studied. This study characterized insulin sensitivity, β‐cell responsivity, and disposition index following a mixed‐meal tolerance test utilizing a minimal model of glucose, insulin, and C‐peptide kinetics before and during treatment with metformin. The study included women with gestational diabetes mellitus (n = 34), T2DM (n = 14), and healthy pregnant women (n = 30). Before treatment, the gestational diabetes mellitus group had significantly higher baseline (45%), dynamic (68%), static (71%), and total β‐cell responsivity (71%) than the T2DM group. Metformin significantly increased insulin sensitivity (51%) as well as disposition index (97%) and decreased mixed‐meal tolerance test peak glucose concentrations (8%) in women with gestational diabetes mellitus after adjustment for gestational age–dependent effects; however, in women with T2DM metformin only significantly affected peak glucose concentrations (22%) and had no significant effect on any other parameters. Metformin had a greater effect on the change in disposition index (Δ disposition index) in women with gestational diabetes mellitus than in those with T2DM (P = .01). In conclusion, response to metformin in women with gestational diabetes mellitus is significantly different from that in women with T2DM, which is likely related to the differences in disease severity.
Changes in Coping and Negative Cognitions as Mechanisms of Change in Online Treatment for Rape‐Related Posttraumatic Stress Disorder
Authors: Littleton Heather , Grills Amie
Published: November 2019

Cognitive behavioral therapy (CBT)–based interventions, including those administered via telepsychology, represent efficacious posttraumatic stress disorder (PTSD) treatments. Despite demonstrated efficacy, limited research has examined mechanisms of change for CBT. We examined trauma‐related cognitions and coping as treatment mechanisms among 46 women who completed a randomized clinical trial of a CBT‐based, telepsychology‐delivered interactive program for rape survivors. The results indicated that both the interactive program, d = 1.5, and the active control condition, a psychoeducational website, d = 1.4, resulted in large reductions in posttest PTSD symptoms. Analysis of residual gain scores showed that reductions in the three types of assessed trauma‐related cognitions were strongly related to reductions in PTSD symptoms among women assigned to the interactive program, rs = .60–.79, but only weakly related to symptom reduction among those assigned to active control, rs = .06–.31. The results also suggest that increases in trauma‐related approach coping were weakly related to reductions in PTSD symptoms among participants in the interactive program, rs = −.16 and −.17, but, conversely, decreases in trauma‐related approach coping were weakly related to reductions in PTSD symptoms among those in the active control group, rs = .07 and .28. Reductions in avoidance coping were modestly related to reductions in PTSD symptoms among women in the interactive program, rs = .38 and .38, but unrelated to changes in PTSD symptoms among those assigned to the active control, rs = .03 and .05. Implications for future work examining mechanisms of change for PTSD treatments are discussed.
Evaluation of Eulychnia acida and Echinopsis chiloensis (Cactaceae) extracts in inhibiting corrosion of carbon steel in HCl solution
Authors: Figueredo Francisco , Vera Rosa , Molinari Aurora
Published: November 2019

In the present study, the activity of extracts obtained from the stems of two endemic species of the central–northern region of Chile (Eulychnia acida [Copao] and Echinopsis chiloensis [Quisco]), was evaluated as potential corrosion inhibitors for carbon steel in 0.1 M HCl. The total content of phenols and flavonoids in the extracts was determined, and the main components were identified by high‐performance liquid chromatography–mass spectrometry, being similar in both species. The inhibition efficiency of extracts was evaluated by mass loss measures, Tafel polarization curves, and electrochemical impedance spectroscopy. The assay results showed similar values in inhibition percentages, around 88% at extract concentrations of 1,500 ppm. The adsorption on the steel surface followed the Langmuir model adsorption isotherm, whose thermodynamic parameters (ΔG°ads for Copao and Quisco, −17.81 and −17.70 kJ/mol, respectively) suggest a physisorption mechanism. The scanning electron microscopy analyses showed that in the presence of the extracts, the surface of the steel is covered by a thin film that allows the sanding marks to be visualized; while without the extracts the surface is rough due to the HCl corrosion effect.
Metastable pitting behaviour of austenite stainless steel under compressive residual stress
Authors: Guan Lei , Cai Jianmin , Yang Xiangyu , Li Yu , Wang Guan
Published: November 2019

Metastable pitting behaviour of austenite stainless steel after compressive deformation in an acidic NaCl solution was investigated. The results show that the pit initiation rate increases while both metastable pit lifetime and growth rate decrease after compressive deformation. Meanwhile, the ratio of the surface oxide fraction of Cr to Fe increases whereas the average size of stable pits is smaller and shallow disk‐shaped under compressive residual stress. The results reveal that with the aid of enrichment of Cr oxides and compressive residual stress, which helps break the remnants of the undermined passive film, pit repassivation can be accelerated.
Way of Kun: the metaphysical foundation of Zhuxi’s female ethics
Authors: Kun Wang
Published: November 2019

Confucianism has a system of Ethical argumentation that is based on Three Cardinal Principles and Five Constant Virtues, directed towards the cultivation of virtue. Neo-Confucianism, especially Lixue 理学 that is initiated by Chengyi 程颐 and developed by Zhuxi 朱熹, puts great emphasis on the theory of cultivation that usually converges instead of being emanative, tinged with the characteristic of the Way of Kun 坤道 that is directed towards the Virtue of Kun 坤德. This cultivation of the mutual dependence of knowing and doing leads to the subordination of the Way of Qian 乾道 and a corresponding change in the relation between the Virtue of Kun and the Virtue of Qian in a range of language levels, as the metaphysical foundation of Zhuxi’s female ethics.
First Observations of the Disruption of the Earth's Foreshock Wave Field During Magnetic Clouds
Authors: Turc L. , Roberts O. W. , Archer M. O. , Palmroth M. , Battarbee M. , Brito T. , Ganse U. , Grandin M. , Pfau‐Kempf Y. , Escoubet C. P. , Dandouras I.
Published: November 2019

The foreshock, extending upstream of Earth's bow shock, is a region of intense electromagnetic wave activity and nonlinear phenomena, which can have global effects on geospace. It is also the first geophysical region encountered by solar wind disturbances journeying toward Earth. Here, we present the first observations of considerable modifications of the foreshock wave field during extreme events of solar origin called magnetic clouds. Cluster's multispacecraft data reveal that the typical quasi‐monochromatic foreshock waves can be completely replaced by a superposition of waves each with shorter correlation lengths. Global numerical simulations further confirm that the foreshock wave field is more intricate and organized at smaller scales. Ion measurements suggest that changes in shock‐reflected particle properties may cause these modifications of the wave field. This state of the foreshock is encountered only during extreme events at Earth, but intense magnetic fields are typical close to the Sun or other stars.