bluuebunny/crossref_metadata_2025 huggingface dataset:
Ozone disc nucleolysis as an alternative to open disc surgery for slip disc
Authors: Sardar K , Das G , Mahta P , Mallick S , Hubbard R
Published: July 2022

Back pain associated with herniated disks has become an important and increasing general health problem, both in Bangladesh and across the world. After all methods of conservative treatment have been exhausted, nucleolysis may be a minimally invasive alternative to surgery. In nucleolysis, chondrolytic substances, or other substances which reduce the pressure within the disk by other means, are injected into the nucleus pulposus under CT or C-arm guidance. Among various substances, which have been employed for nucleolysis, an ozone-oxygen mixture appears to be very promising. The water-binding capacity of ozone results in a reduction of pain. Moreover, it has an anti-inflammatory effects and results in an increase of perfusion to the affected area. Ozone is converted into pure oxygen in the body and has a low allergic potential. Recent minimally invasive therapeutic methods such as percutaneous nucleotomy or laser treatment have not been shown to result in superior results compared with ozone nucleolysis.

JBSA 2012; 25(1): 32-35
Tingkat Diagenesis dan Potensi Serpih Hidrokarbon Formasi Keruh di Daerah Kuantan Singingi, Provinsi Riau Sumatera Tengah
Authors: Tiara Zulfa , P Eko Bayu , Hermiyanto Z Moh Heri
Published: July 2022

Penelitian ini difokuskan pada batuan di Formasi Keruh yang dianggap berpotensi sebagai serpih hidrokarbon (serpih minyak dan serpih gas) pada Formasi Keruh yang berumur Eosen â€“ Oligosen. Pada daerah baratlaut lokasi penelitian (Manunggal, Nusariau, dan Makarya) mempunyai batuan yang berpotensi sebagai serpih minyak, serpih gas, serpih minyak & gas. Pada daerah tenggara daerah penelitian (Prk.TBS dan Sitiung) memiliki batuan yang berpotensi sebagai serpih minyak saja. Tingkat diagenesis batuan sumber hidrokarbon Formasi Keruh termasuk ke dalam tingkat diagenesis kelompok II atau setara dengan Mesogenetik matang A. Diagenesis tingkat ini diakibatkan oleh timbunan dengan kedalaman sampai dengan 3.000 m, dan menghasilkan temperatur purba sampai dengan 900C Katakunci: Diagenesis, Formasi Keruh, hidrokarbon, serpih.Â
Pemodelan Karakteristik Aliran Airtanah Sistem Porous dengan Uji Permeabilitas, Porositas dan Kompresibilitas Batuan pada Fasies Gunungapi Gede-Pangrango Bagian Tenggara
Authors: Suryana Davin Rizqa Haris , Hendarmawan Hendarmawan , Yan Waliyana Teuku
Published: July 2022

Pengertian mengenai geometri keterdapatan airtanah di bawah permukaan, merupakan hal yang penting untuk diketahui. Dengan memahami sifat fisik batuan akuifer maka permasalahan karakteristrik dan sifat airtanah akan lebih mudah untuk dijelaskan. Tujuan studi ini untuk mengidentifikasi litologi apa saja yang dapat menjadi media penyusun akuifer primer (media porous) berdasarkan nilai permeabilitas, porositas dan kompresibilitas batuan penyusun daerah studi, serta bagaimana karakteristik aliran primer air tanahnya berdasarkan model sistem air tanah. Metode yang dilakukan untuk peenyelidikan ini antara lain, uji permeabilitas, porositas, dan kompresibilitas batuan kemudian dipadukan dengan metode statistik kuartil, pemodelan geolistrik, dengan pembagian kategori batuan berdasarkan hasil uji laboratorium batuan. Hasil uji laboratorium batuan dan hasil analisis statistik dengan metode kuartil, skoring dan pembobotan, hasilnya adalah batuan tuf kasar dan tuf halus yang bersifat akuifer, batuan breksi grain supported dan breksi matrik supported bersifat batuan akuitar, batuan lapili bersifat batuan akuiklud, terakhir batuan lava andesit bersifat batuan akuifug. Setelah batuan akuifer dan bukan akuifer diketahui, maka blok model sistem airtanah dapat dibentuk dengan menentukan sebaran batuan berdasarkan data geolistrik. Hasil blok model disimpulkan bahwa perlapisan batuan akuifer mendominasi di fasies distal, untuk fasies medial dan proksimal didominasi oleh batuan yang bersifat bukan akuifer. Aliran airtanah yang terbaca dan terbentuk relatif mengarah ke tenggara.Katakunci: Aliran airtanah primer, ekplorasi airtanah, karakteristik aliran airtanah, pemodelan airtanah.
Geokimia dan Umur Absolut Sebagai Penanda Dominasi Sistem Laut dan Perubahan Fasies Aluvium di Daerah Pesisir Gresik
Authors: Purnamaruslia Yudistira , Muslim Dicky , Iskandarsyah Teuku Y.W.M
Published: July 2022

Endapan aluvium tersebar di sepanjang pantai utara Jawa Timur termasuk di Kabupaten Gresik. Penyelidikan ini bermaksud untuk menganalisis unsur geokimia endapan aluvial untuk mengetahui pengaruh dominasi sistem laut atau darat, dan pentarikhan radiokarbon pada lapisan aluvium untuk mengetahui perubahan fasies pengendapan pada kala Holosen. Pengeboran dilakukan pada tujuh titik dengan sebaran empat titik di sebelah barat sungai Bengawan Solo dan tiga titik di sebelah timur sungai ke arah pantai. Untuk menentukan umur lapisan digunakan metode pentarikhan radiokarbon. Sampel batuan ke-tujuh titik bor dianalisis XRF untuk mengetahui unsur geokimia seperti Ca, Ti, Fe, Sr, K, Mn, V. Unsur Ca dan Sr mengindikasikan dominasi pengaruh laut, sedangkan kelimpahan unsur Fe dan K mengindikasikan adanya pengaruh darat. Pada titik bor 22 paling dekat dengan laut terlihat rata-rata logam berat Fe, Mn dan V yang semakin dalam semakin rendah, berbanding terbalik dengan unsur logam ringan Ca dimana semakin dalam semakin besar nilainya. Pada titik bor 19 yang letaknya jauh dari pantai terlihat logam berat Fe, Mn dan V semakin dalam semakin besar nilainya dan unsur logam ringan trendnya semakin dalam semakin kecil. Tujuh sampel lempung telah dilakukan analisa pentarikhan radiokarbon menghasilkan rentang umur 7.210 hingga 3.840 tahun yang lalu. Pada umur lebih dari 7.210 lingkungan pengendapan didominasi oleh endapan nearshore. Pada umur antara 7.000 dan 3.000 tahun yang lalu lingkungan pengendapan berupa endapan rawa, rawa pasang surut, dan endapan pantai. Lebih muda dari 3.000 tahun yang lalu lingkungan pengendapan didominasi oleh endapan pasang surut dan limpah banjir, setempat berupa lingkungan rawa.Katakunci: Aluvium, geokimia, Gresik, Holosen, radiokarbon.
Türkiye’nin Ülke İmajı ile Genel Ürün İmajının Yerli Otomobil TOGG’un Algılanan Ürün İmajına ve Satın Alma Niyetine Etkisi
Authors: TİLKİ İlay , BOZKURT Bilgehan , AKTAN Murat , KOÇAK Ahmet
Published: July 2022

Uluslararası pazarlama literatüründe, ürünlerin algılanan imajlarının tüketicilerin algıladıkları ülke imajı ve genel ürün imajından etkilendiği konusunda bir uzlaşı söz konusudur. Türkiye’nin Otomobili Girişim Grubu’nun TOGG markasıyla üreteceği yerli otomobillerin iki modeli, oldukça rekabetçi olan otomotiv piyasasına, 2024 yılına kadar arz edilecektir. Buradan yola çıkan bu araştırma, TOGG markasının algılanan ürün imajını ve satın alma niyetini, Türkiye’nin genel ürün ve ülke imajı kapsamında incelemektedir. 368 kişiden toplanan veri ve uygulanan Yapısal Eşitlik Modeli (YEM) ile, Türkiye’nin ülke imajı ile genel ürün imajının TOGG’un algılanan ürün imajına etkisi olduğu ortaya konulmuştur. Bunun yanı sıra, TOGG’un algılanan imajının da satın alma niyeti üzerine anlamlı ve pozitif bir etkisi olduğu gözlenmiştir. Bu çalışma, gelişmekte olan bir ülkenin ülke-ürün imajını araştırması, yerli elektrikli bir otomobil satın alma davranışı ile bütünsel olarak ele alması ve genel ürün imajı ile ülke imajını Türkiye özelinde ikincil düzey bir faktör olarak ölçmesi ile pazarlama literatürüne önemli bir katkıda bulunmaktadır. Araştırma bulguları ile ayrıca, otomotiv sektörüne çeşitli önerilerde bulunulmaktadır.
On the Exponential Diophantine Equation $(6m^{2}+1)^{x}+(3m^{2}-1)^{y}=(3m)^{z}$
Authors: ALAN Murat , BİRATLI Ruhsar Gizem
Published: July 2022

Let $m$ be a positive integer. In this paper, we consider the exponential Diophantine equation $(6m^{2}+1)^{x}+(3m^{2}-1)^{y}=(3m)^{z}$ and we show that it has only unique positive integer solution $(x,y,z)=(1,1,2)$ for all $ m>1. $ The proof depends on some results on Diophantine equations and the famous primitive divisor theorem.
Prébiotico isolado ou combinado com probiótico tem efeito positivo sobre digestibilidade de matéria orgânica, desempenho, resposta imune e antioxidante de bezerros após o desaleitamento
Authors: Lago Rafael Vinicius Pansera , Vitt Maksuel Gatto de , Brunetto Andrei L. R. , Bissacotti Bianca F. , Copetti Priscila M. , Carvalho Raissa A. , Pereira Wanderson A. B. , Solivo Gabriela , Zotti Claiton A. , Vedovatto Marcelo , Silva Aleksandro Schafer Da
Published: July 2022

O objetivo desse estudo foi avaliar se a adição de combinação de probiótico (PROB) e prébioticos (PREB) ou ambos sozinhos na dieta de bezerros holandeses após o aleitamento tem efeito positivo na resposta imune e antioxidante capaz de favorecer o crescimento do animal. Dezoito animais da raça holandesa (79,2 kg e 70 dias de idade), alojados em baias individuais por 92 dias foram usados aqui, e divididos em três tratamentos: PROB (n=6), PREB (n=6) e PROB+PREB (n=6). O consumo de PREB e da associação PREB+PROB gerou um ganho de peso corporal cerca de 10% a mais que o PROB. No hemograma, a única alteração foi a interação tratamento x dia para contagem de monócitos, sendo maior no dia 63 e 92 no sangue dos animais do PREB e PROB, respectivamente, comparado aos demais grupos. A associação PREB + PROB a partir do dia 63 elevou a atividade da enzima glutationa S-transferase em 14% quando comprado ao consumo de apenas PREB, além de reduzir em 35% os níveis de TBARS no sangue. Além disso, a associação de PREB+PROB reduziu em 12,5% e 16,2% a concentração de ureia sérica em relação ao PREB e PROB, respectivamente. Animais do grupo PREB+PROB tiveram maiores níveis de IgA no soro em relação ao PROB, ao contrário do que ocorreu referentes aos níveis de IGG de cadeia pesada, isto é, foi maior no PROB comparado a associação PREB+ PROB. No dia 63 foi observado menores níveis haptoglobina no PREB comparado aos demais grupos. No dia 92 foi observado menores níveis de transferrina e glicoproteína acida para a no sangue dos animais que consumiram PREB+PROB. Também no dia 92, níveis de ceruplasmina no soro do PROB foi maior que nos animais do PREB. Foi observado coeficiente de digestibilidade aparente (CDA) de matéria orgânica (MO) maior quando os animais consumiram prébiotico comparado ao probiótico, sendo que a associação de ambos não diferiu dos dois tratamentos para CDA de MO. Os resultados permitem concluir a associação PREB+PROB foi importante para minimizar o estresse oxidativo fisiológico, assim como elevar os níveis séricos de IgA, imunoglobulina de mucosa importante a nível de sistema digestivo; além disso a combinação de resultados fisiológicos do consumo de prébiotico isolado ou combinado refletiu em maior ganho de peso dos bezerros.
A importância dos primeiros socorros para profissionais de educação física: uma revisão integrativa
Authors: Medeiros Maria Clara de Melo , Lima Mylena Suely Araújo , Leal Evaldo Sales , Lima Bruna Daniella de Sousa de , Souza Carliane Maria de Araújo , Souza Maria Anasha Costa
Published: July 2022

Introdução: Pode-se definir primeiros socorros como o atendimento imediato que deve ser prestado de maneira rápida a pessoas em condições físicas potencialmente fatais. Durante o exercício de sua profissão, o profissional pode deparar-se com diversas situações onde necessita intervir de maneira adequada. Dessa forma, o presente estudo teve como objetivo retratar o que as evidências demonstram sobre a importância dos primeiros socorros para profissionais de Educação Física. Metodologia: Tratou-se de uma revisão integrativa a fim de reunir e sintetizar os resultados. Resultados: Com a pesquisa foi evidenciado que grande parte dos profissionais atuantes ainda apresentam pouco ou nenhum conhecimento sobre os primeiros socorros e a importância de um maior preparo dos educadores para proceder em circunstâncias por vezes intempestivas. Ressaltando a necessidade de atualização das Diretrizes Curriculares Nacionais (DCN) do curso de Educação Física, assim como a necessidade de aplicabilidade prática dos conceitos de primeiros socorros por parte desses profissionais.
O impacto do cyberbullying na saúde mental de crianças e adolescentes durante a pandemia de COVID-19
Authors: Pereira Isabela Fernandes de Melo , Tissiani Amanda Apolori , Mendonça Gilberto José Góes de , Deininger Layza de Souza Chaves , Ramos André Luís Belmiro Moreira , Oliveira Márcya Cândida Casimiro de , Sousa Ana Luiza Dias Arruda da Silva , Minhoto Talita Barbosa
Published: July 2022

Diante do contexto pandêmico, ocorreu aumento da vivência das pessoas no mundo virtual, sobretudo crianças e adolescentes. Com isso, surge a necessidade de identificar sinais de mau uso dessa ferramenta, bem como suas consequências no público em questão. Nesse sentido, esse trabalho busca analisar a literatura científica sobre o impacto do cyberbullying na saúde mental de crianças e adolescentes durante a pandemia de COVID-19. Quanto à metodologia, foi realizada uma revisão integrativa da literatura a partir da análise de artigos publicados entre 2020 e 2022, disponíveis nas bases de dados: Pubmed, BVS, Scielo e Lilacs. A questão norteadora do artigo foi: Qual o impacto do cyberbullying na saúde mental de crianças e adolescentes durante a pandemia de COVID-19? Os resultados encontrados foram o aumento significativo da incidência do cyberbullying entre crianças e adolescentes durante a pandemia de COVID-19, desencadeando consequências relevantea nessa população, sendo sintomas de ansiedade, depressão e ideação suicida as principais consequências dessa prática. Como conclusão, verificou-se que houve impacto significativo do cyberbullying na saúde mental de crianças e adolescentes durante a pandemia de COVID-19, sendo algumas opções de intervenção identificadas: a criação de aplicativo de interação com as vítimas e de programa escolar preventivo figuram entre as  intervenções mais eficazes.
Evidências científicas sobre o acesso aos serviços de saúde pela população LGBTQI+: Revisão de escopo
Authors: Ferreira Aldo Pacheco , Nichele Cintia da Silva Telles , Jesus Jaqueline Gomes de , Vianna Marcos Besserman , Cardoso Gisela Cordeiro Pereira , Salles Inês Cristina Di Mare , Santos Jéssica Barreto dos , Silva Angélica Baptista , Girianelli Vania Reis , Cotrim Junior Dorival Fagundes
Published: July 2022

A relação entre usuários e serviços de saúde é essencial para fortalecer a qualidade da assistência. A população LGBTI+ que é composta por populações que se definem pela diversidade de identidade e de expressão de gênero, orientação sexual e sexo biológico, sofre preconceito e discriminação no acesso e uso desses serviços. Este estudo teve como objetivo identificar as evidências científicas na população LGBTQI+, de maneira a dar visibilidade as adversidades relacionadas ao acesso e utilização dos serviços de saúde. Revisão de escopo realizada nas bases: CINAHL, EBSCOhost, EMBASE; Latindex; LILACS, MEDLINE, Science Direct, SciELO, SCOPUS, Web of Science, com período aberto. Foram incluídos artigos originais com texto completo disponíveis online no idioma inglês, espanhol ou português, com o objeto de estudo dados do Brasil. A busca resultou em 1.332 artigos potencialmente elegíveis e, adicionalmente, mais 4 artigos advindos de referências de artigos selecionados na pesquisa, totalizando 1336 artigos. Destes, 22 atenderam a todos os critérios de inclusão. Evidências demonstraram que a população LGBTQI+ sofre discriminação em ambientes de saúde e, via-de-regra, barreiras de acesso. O estigma, a discriminação, as normas culturais e sociais que dão preferência à heterossexualidade, cisgenerismo e endossexismo são algumas das causas que contribuem para essas desigualdades em saúde. Os resultados deste estudo evidenciam lacunas nas competências culturais em relação à saúde, a falta de conscientização e conhecimento das necessidades únicas de saúde da população LGBTQI+, juntamente com atitudes não-inclusivas, foram identificadas como possíveis fatores contribuintes entre profissionais e gestores de saúde.
Carbapenem-resistant bacteria in an intensive care unit: prevalence and associated factors
Authors: Menezes Jane Martins de Araújo de , Nascimento Diego Zapelini do , Marques Gabriela Moreno , Fortuna Cássia Tasca , Soares Alessandra de Sá , Schuelter-Trevisol Fabiana
Published: July 2022

Antimicrobial resistance is a global threat that requires different care and factors involved including a unified, multidimensional approach, with greater epidemiological surveillance. The objective this study was to review the prevalence and factors associated with healthcare-related infections (HAI) caused by bacteria resistant to carbapenems in adult patients admitted to the Intensive Care Unit (ICU). This was a cross-sectional study accomplished through the review of electronic medical records and microbiological tests of patients admitted to the ICU of a hospital in southern Santa Catarina between 2010 and 2017. Demographic, clinical and antimicrobial use data were part of the variables of interest. A total of 1,273 HAI cases were included, 11.5% of the hospital infection rate. The mean age of patients was 60.4±18.5 years; 58.7% of the patients were men. The main cause of hospitalization was cardiac-related diseases (35.8%) and the median hospital stay was 31 days. Of the total number of cases, 24% were due to carbapenem resistance. HAIs caused by Escherichia coli, coagulase-negative Staphylococcus/Staphylococcus aureus and Streptococcus sp. were the pathogens that showed greater resistance to carbapenems. Resistance to carbapenems was associated with longer hospital stay (p=0.014), surgical procedure (p<0.001), use of nasoenteral tube (p=0.048) and death (p=0.003). There was a high rate of infection by bacteria resistant to carbapenems. The observed rate of HAIs increased in frequency significantly over the duration of the study period.
Análise dos microdados de matemática do ENEM de 2017–2019 do Nordeste
Authors: Rocha Francisco Bruno Nascimento da , Costa Juliana Evaristo , Maia José Gilvan Rodrigues , Castro Filho José Aires de , Vasconcelos Francisco Herbert Lima
Published: July 2022

O Exame Nacional do Ensino Médio (ENEM) é uma das principais avaliações da Educação Básica brasileira, pois os dados obtidos pela sua aplicação influenciam a elaboração de políticas públicas e a prática em sala de aula. Entretanto, um dos principais desafios do ENEM é ser um instrumento de avaliação acessível para os diferentes públicos do Brasil, levando-se em consideração os fatores sociais, econômicos, regionais e de acessibilidade. Dessa forma o objetivo desse trabalho é conhecer os microdados de desempenho da região Nordeste da área de Matemática e suas tecnologias do ENEM, nos anos de 2017 a 2019, e traçar reflexões sobre como os fatores sociais influenciam o desempenho dos estudantes nessa área. Deste modo, inicialmente foi realizada uma pesquisa bibliográfica a fim de conhecer o Exame, sua aplicação e como ele orienta as políticas públicas para o Ensino Médio e o Ensino Superior. Posteriormente, foi feita uma pesquisa documental nos microdados de desempenho da área de Matemática nos anos de 2017 a 2019, com objetivo de analisar a influência de fatores sociais no desempenho de Matemática dos participantes da região Nordeste. Na última etapa da pesquisa descrevemos os resultados e as observações sobre os dados analisados. Percebe-se que os fatores socioeconômicos, as estruturas familiares e a escola influenciam o desempenho de matemática dos participantes do ENEM e que é necessário conhecer o contexto social deles, pois possibilitará a elaboração de ações e políticas públicas no âmbito educacional, de modo a proporcionar condições de igualdade a todos os participantes.
Compreensão dos acadêmicos de odontologia sobre o câncer bucal: análise do conhecimento dos estudantes do curso de odontologia do Centro Universitário Maurício de Nassau
Authors: Silva Alícia Marcelly Souza de Mendonça , Silva Ana Cláudia da , Alencar Filho Arnoldo Vasconcelos de , Melo Beatriz Lira Tavares de , Santos Giovana Pereira de Holanda , Silva Hitalo Klainer da Nóbrega , Santos Maria Beatriz  Silva dos , Andrade Raiane Antônia de , Santos Rute Oliveira dos , Cavalcanti Ully Dias Nascimento Tavora
Published: July 2022

Este estudo tem como objetivo analisar o conhecimento do câncer bucal por parte dos acadêmicos do Centro Universitário Maurício de Nassau, unidade Graças, buscando minimizar as dificuldades no reconhecimento do câncer bucal e as lesões orais potencialmente malignas. Foi realizada uma pesquisa observacional de caráter transversal, com abordagem quantitativa, entre alunos do 4º ao 10º período do curso de odontologia. Utilizou-se um questionário na plataforma Google Forms para coleta de dados. Para análise dos dados foram obtidas distribuições absolutas e percentuais, medidas estatísticas e medidas de associação. O resultado obtido em nosso estudo, demonstra um despreparo dos acadêmicos em reconhecer práticas de auto avaliação, bem como diagnóstico e orientação eficaz ao paciente, mesmo em períodos avançados do curso de odontologia. Foi possível constatar que o nível de conhecimento dos acadêmicos de odontologia do Centro Universitário Maurício de Nassau é insuficiente. A inconsistência de alguns achados reforça a importância do investimento em medidas e condutas que contribuam com a formação e capacitação do acadêmico odontologia.
Laboratory diagnosis for human chimerism: systematic review
Authors: Weber Douglas Mroginski , Rocha Marcia Juciele da , Nogueira Amanda Carvalho , Teixeira Anna Felícia de Matos , Bonfim Morgana Paz , Rosa Jayne Mendonça Campos , Cruz Marcos Vinicios Bueno da
Published: July 2022

The objective of the article was to perform a systematic review of the literature on laboratory diagnosis for human chimerism. The Medical Literature Analysis and Retrieval System Online (Medline), Public Medline or Publisher Medline (PubMed), Scientific Electronic Library (Scielo), Latin American and Caribbean Literature on Health Sciences (LILACS) databases were searched according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology. Articles were included that had as an endpoint evidencing the diagnosis for chimerism in humans, published in the period from 2005 to 2018. Articles whose endpoint was the occurrence of other types of chimerism were excluded. To compose the study, 36 articles were pre-selected, of these only 6 met the inclusion criteria given by the PRISMA method. Regarding the diagnostics used in the articles to detect chimerism, in 100% of the articles there is reference to the Polymerase Chain Reaction (PCR) combined with other techniques as the main diagnostic for detection of chimerism, such as Fluorescent in situ hybridization (FISH), Short Tandem Repeats (STR), Single Nucleotide Polymorphisms (SNPs), Small Insertions and Deletions (INDELs), Single Molecular Inversion Molecular Probes (smMIP) and TaqMan type molecular probes. These combined techniques have many advantages and are decisive for the scientific community in revealing this genetic condition. Thus, it is concluded that there are few techniques that allow a specific diagnosis for chimerism, however, the existing techniques are effective in identifying this genetic condition.
Cuidados paliativos e transplante de medula óssea: uma revisão integrativa da literatura
Authors: Vendramini Denise Maria , Oliveira-Cardoso Érika Arantes de
Published: July 2022

Introdução: O Transplante de Medula Óssea (TMO) consiste em um tratamento de importante potencial curativo, o que desperta grande esperança em pacientes vivenciando doenças que exercem grave ameaça à continuidade da vida. Entretanto, tal tratamento é permeado por altos riscos, além da possibilidade de recaída da doença ainda existir após o mesmo, dessa forma, faz-se importante considerar abordagens de cuidado que abarquem essa imprevisibilidade, como os Cuidados Paliativos. Objetivo: Descrever quais as contribuições da abordagem de cuidados paliativos no transplante de medula óssea, que se caracteriza como um tratamento de proposta curativa a pacientes com doenças que exercem grave ameaça à continuidade da vida. Método: Revisão Integrativa da Literatura realizada nas bases de dados Scopus, PubMed, PsychINFO e LILACS, abarcando estudos de 2011 a 2021. Os estudos foram categorizados a partir da análise de conteúdo. Resultados: Após aplicação dos critérios de exclusão restaram seis estudos que compuseram o corpus deste trabalho. Resultados demonstraram que a integração precoce de cuidados paliativos ao cuidado padrão de TMO contribui significativamente para o manejo de sintomas físicos e emocionais, exploração de temáticas não abordadas por outros profissionais, como o enfrentamento do momento, bem como discussões sobre planejamento antecipado de cuidado. Conclusão: Os Cuidados Paliativos agregam inúmeros ganhos em relação ao cuidado do paciente submetido ao TMO. Nota-se, porém, a escassez de trabalhos envolvendo as duas temáticas e a necessidade de desenvolver novos estudos que possam fomentar essa prática dentro das clínicas de TMO.
A mobilização do sistema metacognitivo por meio de questionários: resultados de um estudo longitudinal
Authors: Corrêa Nancy Nazareth Gatzke , Passos Marinez Meneghello , Arruda Sergio de Mello , Corrêa Hugo Emmanuel da Rosa
Published: July 2022

Neste artigo trazemos os resultados de uma investigação que procurou verificar de que forma os questionários aplicados para a coleta de dados configuraram-se como incentivo de entrada ao sistema metacognitivo no processo da aprendizagem em Física. Tal coleta foi realizada ao longo de três anos com estudantes do Ensino Médio. O instrumento proposto para a coleta de dados foi constituído de quatro questionários denominados por: “Autoavaliação” (Q1); “Após a Avaliação” (Q2); “Inventário Metacognitivo” (Q3); e “Questionário Final” (Q4). Analisando as respostas dos estudantes, pôde-se concluir que os questionários Q1 foram instrumentos de incentivo metacognitivo e que proporcionaram a inserção ao processo por meio da reflexão metacognitiva que foi o gatilho para acessar o conhecimento metacognitivo, tanto do autoconhecimento como das manifestações da experiência metacognitiva. Com os questionários Q2 e Q3, foi possível sinalizar que estes também funcionaram como incentivo à entrada ao sistema metacognitivo, possivelmente, por meio da ativação, em alguns momentos, do conhecimento metacognitivo processual. O questionário Q4 proporcionou a identificação do conhecimento metacognitivo, em que o estudante aciona as memórias do processo de tomada de consciência das condições que as estratégias utilizadas afetaram a aprendizagem.
Aplicações de visão computacional na saúde: revisão de literatura incrementada com técnicas de processamento de linguagem natural
Authors: Constâncio Alex Sebastião , Carvalho Deborah Ribeiro , Tsunoda Denise Fukumi
Published: July 2022

Os sistemas de visão computadorizada (CVS) têm recebido atenção especial dos pesquisadores por sua adaptabilidade a vários contextos, especialmente na área de segurança para reconhecimento de imagem e vídeo. Este artigo apresenta uma revisão bibliográfica sobre o uso da visão computacional na área da saúde nos últimos cinco anos (2017-2021), bem como tendências e análises para os seis primeiros meses de 2022. Os bancos de dados Science Direct, Scopus, Web of Science, ACM Digital Library e IEEE Xplore foram usados para conduzir a pesquisa. Um total de 2.072 artigos foram recuperados (2017 a 2021) e 492 artigos em 2022 e destes, após deduplicação, 1.857 trabalhos compuseram o corpus 2017-2021 e 465 o corpus 2022. Técnicas de Processamento de Linguagem Natural foram adotadas para extração de multigramas que geraram nuvens de palavras dos resumos dos artigos recuperados. Também métricas como periódicos que mais publicam sobre o tema, a partir de funcionalidades do Biblioshiny (pacote Bibliometrix do R). O Brasil aparece apenas em três documentos: um de pesquisadores da Universidade Federal do Acre, um da Universidade Estadual de Maringá e outro da Universidade Federal de Santa Catarina. Os pesquisadores chineses aparecem como os mais produtivos e o aprendizado profundo é a principal tecnologia adotada para este tipo de estudo. As doenças mais evidentemente exploradas no período são câncer de mama e COVID-19.
HUBUNGAN PERSEPSI MAHASISWA DENGAN STRES AKADEMIK DALAM PEMBELAJARAN ONLINE DI MASA PANDEMI COVID-19
Authors: RIZKI ARIANI DWI SINTA
Published: July 2022

ABSTRACT

Ariani, Dwi Sinta Rizki. 2021. The Correlation of Student’s Perception with Academic Stress in The  Implementation of Online Learning in The Covid-19 Pandemic on Semester II Students of Widyagama Husada School of Health Malang. Thesis. Nursing Study Program of Widyagama Husada School of Health Malang.  Advisors: (1) Miftakhul Ulfa, S.kep., Ners.,M.Kep. (2) Waifti Amalia, S.ST., M.Keb.

Background: Students as the most numerous individuals in educational institutions certainly feel the impact of the COVID-19 pandemic, where the learning system that is usually carried out face-to-face, either on campus or on practice location, has turned online. The stress experienced by the students during the study period may disturb students mindsets due to the complexity of the problems they face. The students are not only required to have technical expertise, but they are also required to have a certain attitude and mindsets so that the broad insights gained by students can be applied in their social environment.

Objectives: To find out the correlation between student perceptions and academic stress in the application of online learning during the COVID-19 pandemic for second semester students of STIKes Widyagama Husada Malang.

Research methods: The research design used in this study was descriptive correlation with a retrospective approach. The population in this study were second semester students of STIKes Widyagama Husada Malang. Samples were taken using a purposive sampling technique with a total of 80 respondents.

Research result: The results of the research indicated majority of second semester students of STIKes Widyagama Husada Malang experienced mild academic stress.

Conclusion: There is a correlation between student perceptions and academic stress in the application of online learning during the COVID-19 pandemic for second semester students of STIKes Widyagama Husada Malang.

References: 32 References (2010-2020)

Keywords: Student Perception, Academic Stress, Online Learning
South Pacific Tropical Upper Tropospheric Trough (TUTT): variability and impact on the French Polynesian climate
Authors: Laurent V , Maamaatuaiahutapu K , Hopuare M , Varney P , Ortega P
Published: July 2022

The South Pacific Tropical Upper Tropospheric Trough (TUTT) is an elongated trough that appears in summer monthly averaged maps of the upper tropospheric flow over the ocean. We provide the first comprehensive description of the South Pacific TUTT and analyze its impact on the regional climate with 42 yr (1979-2020) of monthly data from ERA5, radiosonde, rain, keraunic data, and lightning flash rate from the Optical Transient Detector-Lightning Imaging Sensor. The data confirm the presence of the TUTT along a southeast-northwest axis from November to May. Located between 100 and 400 hPa, the TUTT is a cold-core with a relative vorticity minimum and a negative geopotential anomaly. Divergent, ascending flow with high relative humidity is found south and west of the TUTT axis, while convergent, descending flow with low relative humidity is observed north and east of the TUTT axis. The seasonal and long-term impacts of the TUTT on the local and regional climate is dependent on its location and its strength. The existence of the TUTT in the South Pacific is strongly dependent on the El Niño-Southern Oscillation (ENSO) phases, being stronger during a strong negative ENSO phase and disappearing from French Polynesia during a strong positive ENSO phase. Genesis of tropical disturbances east of 180°W is possible only if the TUTT is located east of 120°W. The environmental conditions associated with the TUTT, along with lightning and rainfall data from 3 sites in French Polynesia, show that lightning flash rates are higher during a negative ENSO phase than during a positive ENSO phase.
At-sea behavioural ecology of the endangered MacGillivray’s prion from Saint Paul Island: combining tracking and stable isotopes
Authors: Delord K , Cherel Y , Roy A , Bustamante P , Swadling KM , Weimerskirch H , Bost CA , Barbraud C
Published: July 2022

Seabirds play important roles as marine ecosystem sentinels. Studying their at-sea ecology is essential for understanding how environmental variability affects their populations. However, the at-sea ecology of small-sized temperate seabirds remains poorly studied. We explored the at-sea ecology of the Critically Endangered MacGillivray’s prion Pachyptila macgillivrayi breeding on the subtropical Saint Paul Island. Using global location sensor loggers and stable isotope analysis, we investigated movements, migratory strategies, at-sea activity and moulting period, and characterized the isotopic niche of tracked individuals. During incubation, MacGillivray’s prions remained in temperate waters north of the Subtropical Front, possibly feeding on prey caught in cold eddies. During the inter-breeding period, individuals wintered almost equally to the north and south of the Subtropical Front in 2 distinct sectors (Tasman Sea and Southwest Indian Ridge). Daily activity varied seasonally, and individuals overwintering in the Tasman Sea spent more time flying at night when moonlight intensity was high. Moulting occurred after the breeding period and lasted longer compared to other prion species. Isotopic data suggest a higher dietary proportion of low trophic-level prey for MacGillivray’s prions than for Antarctic and slender-billed prions, highlighting trophic segregation in relation to bill width. Our study provides new evidence to understand the suite of adaptations allowing the abundant prion species to coexist by feeding on prey of different sizes. Contrary to the majority of seabird species, MacGillivray’s prions from Saint Paul Island exhibited 2 migratory tactics with associated differences in at-sea activity, leading to questions about the origin of these differences.
Pushing Intersectionality, Hybridity, and (Inter)Disciplinary Research on Digitality to Its Limits: A Conversation Among Scholars of Gender, Sexuality, and Embodiment
Authors: Geerts Evelien , Rahbari Ladan , Evolvi Giulia , Zarabadi Shiva , De Vuyst Sara
Published: July 2022

During the past two decades or so, the emergence and ever-accelerating development of digital media have sparked scholarly interest, debates, and complex challenges across many disciplines in the social sciences and the humanities. Within this diverse scholarship, the research on digitality, gender, sexuality, and embodiment has contributed substantially to many academic fields, such as media studies, sociology, religion, philosophy, and education studies. As a part of the special issue “Gender, Sexuality, and Embodiment in Digital Spheres: Connecting Intersectionality and Digitality,” this roundtable consists of a conversation between five researchers from different (inter)disciplinary locations, all addressing matters of methodology, intersectionality, positionality, and theory in relation to the topics of gender, sexuality, and embodiment in digital spheres. Said roundtable begins with a critical self-positioning of the participants’ (inter)disciplinary and embodied locations using examples from their own research. The conversation then progresses to how these researchers have employed contemporary theories, conceptual vocabularies, methods, and analyses of gender, sexuality, and embodiment in digital spheres to then conclude with some ethico-political notes about collaborations between scholars and (digital) activists.
Rethinking ‘Sex Robots’: Gender, Desire, and Embodiment in Posthuman Sextech
Authors: Locatelli Chloé
Published: July 2022

This paper interrogates the posthuman potential of sextech aimed at heterosexual men, positing that advertising and design of products with digital femininities emphasise the possibility for emotional interaction. This work firstly applies pressure to the monolithic conceptualisation of ‘sex robots’, that impedes rigorously appraising existing sextech constructions. Applying posthuman theory to sextech, particularly critical posthumanism and the formative work of Donna Haraway, affords this investigation the theoretical rigour to reflect on the potential for emotional interaction with digital feminised others. Through digital media analysis, this paper explores three gendered-female technologies: Azuma Hikari, (2020); the RealdollX Application (2020) and VirtualMate (2020) alongside their concomitant promotional material. This research illustrates that the complex convergence of interactive technologies, digital feminities and emotive advertising suggests a shift into posthuman sextech – where digital feminities are designed and advertised as capable of providing erotic and emotive interaction.
Exact Equation of Ellipse Perimeter by Analytical Method
Authors: Soltani Abolfazl
Published: July 2022

As you know, we do not have any exact equation for calculating the perimeter of an ellipse. In this article, we obtain this equation analytically. This is the equation we have been looking for, at least since Leonhard Euler. In this article we will find a way for derivation of the solution of Elliptic integral in terms of elementary functions.
A case–control study of infections caused by Klebsiella pneumoniae producing New Delhi metallo-beta-lactamase-1: Predictors and outcomes
Authors: Rodríguez-Noriega Eduardo , Garza-González Elvira , Bocanegra-Ibarias Paola , Paz-Velarde Beatriz Alejandra , Esparza-Ahumada Sergio , González-Díaz Esteban , Pérez-Gómez Héctor R. , Escobedo-Sánchez Rodrigo , León-Garnica Gerardo , Morfín-Otero Rayo
Published: July 2022

Introduction

Infections caused by antimicrobial-resistant bacteria are a significant cause of death worldwide, and carbapenemase-producing bacteria are the principal agents. New Delhi metallo-beta-lactamase-1 producing Klebsiella pneumoniae (KP-NDM-1) is an extensively drug-resistant bacterium that has been previously reported in Mexico. Our aim was to conduct a case–control study to describe the risk factors associated with nosocomial infections caused by K. pneumoniae producing NDM-1 in a tertiary-care hospital in Mexico.

Methods

A retrospective case–control study with patients hospitalized from January 2012 to February 2018 at the Hospital Civil de Guadalajara “Fray Antonio Alcalde” was designed. During this period, 139 patients with a culture that was positive for K. pneumoniae NDM-1 (cases) and 486 patients hospitalized in the same department and on the same date as the cases (controls) were included. Data were analyzed using SPSS v. 24, and logistic regression analysis was conducted to calculate the risk factors for KP-NDM-1 infection.

Results

One hundred and thirty-nine case patients with a KP-NDM-1 isolate and 486 control patients were analyzed. In the case group, acute renal failure was a significant comorbidity, hospitalization days were extended, and significantly more deaths occurred. In a multivariate analysis of risk factors, the independent variables included the previous use of antibiotics (odds ratio, OR = 12.252), the use of a urinary catheter (OR = 5.985), the use of a central venous catheter (OR = 5.518), the use of mechanical ventilation (OR = 3.459), and the length of intensive care unit (ICU) stay (OR = 2.334) as predictors of infection with NDM-1 K. pneumoniae.

Conclusion

In this study, the previous use of antibiotics, the use of a urinary catheter, the use of a central venous catheter, the use of mechanical ventilation, and ICU stay were shown to be predictors of infection with NDM-1 K. pneumoniae and were independent risk factors for infection with NDM-1 K. pneumoniae.
Distinct Cohorts of Aspergillus fumigatus Transcription Factors Are Required for Epithelial Damage Occurring via Contact- or Soluble Effector-Mediated Mechanisms
Authors: Rahman Sayema , van Rhijn Norman , Papastamoulis Panagiotis , Thomson Darren D. , Carter Zorana , Fortune-Grant Rachael , Rattray Magnus , Bromley Michael John , Bignell Elaine
Published: July 2022

Damage to the lung epithelium is a unifying feature of disease caused by the saprophytic fungus Aspergillus fumigatus. However, the mechanistic basis and the regulatory control of such damage is poorly characterized. Previous studies have identified A. fumigatus mediated pathogenesis as occurring at early (≤ 16 hours) or late (>16 hours) phases of the fungal interaction with epithelial cells, and respectively involve direct contact with the host cell or the action of soluble factors produced by mature fungal hyphae. Both early and late phases of epithelial damage have been shown to be subject to genetic regulation by the pH-responsive transcription factor PacC. This study sought to determine whether other transcriptional regulators play a role in modulating epithelial damage. In particular, whether the early and late phases of epithelial damage are governed by same or distinct regulators. Furthermore, whether processes such as spore uptake and hyphal adhesion, that have previously been documented to promote epithelial damage, are governed by the same cohorts of epithelial regulators. Using 479 strains from the recently constructed library of A. fumigatus transcription factor null mutants, two high-throughput screens assessing epithelial cell detachment and epithelial cell lysis were conducted. A total of 17 transcription factor mutants were found to exhibit reproducible deficits in epithelial damage causation. Of these, 10 mutants were defective in causing early phase damage via epithelial detachment and 8 mutants were defective in causing late phase damage via epithelial lysis. Remarkably only one transcription factor, PacC, was required for causation of both phases of epithelial damage. The 17 mutants exhibited varied and often unique phenotypic profiles with respect to fitness, epithelial adhesion, cell wall defects, and rates of spore uptake by epithelial cells. Strikingly, 9 out of 10 mutants deficient in causing early phase damage also exhibited reduced rates of hyphal extension, and culture supernatants of 7 out of 8 mutants deficient in late phase damage were significantly less cytotoxic. Our study delivers the first high-level overview of A. fumigatus regulatory genes governing lung epithelial damage, suggesting highly coordinated genetic orchestration of host-damaging activities that govern epithelial damage in both space and time.
Streptococcus pneumoniae interactions with the complement system
Authors: Gil Eliza , Noursadeghi Mahdad , Brown Jeremy S.
Published: July 2022

Host innate and adaptive immunity to infection withStreptococcus pneumoniaeis critically dependent on the complement system, demonstrated by the high incidence of invasiveS. pneumoniaeinfection in people with inherited deficiency of complement components. The complement system is activated byS. pneumoniaethrough multiple mechanisms. The classical complement pathway is activated by recognition ofS. pneumoniaeby C-reactive protein, serum amyloid P, C1q, SIGN-R1, or natural or acquired antibody. SomeS. pneumoniaestrains are also recognised by ficolins to activate the mannose binding lectin (MBL) activation pathway. Complement activation is then amplified by the alternative complement pathway, which can also be activated byS. pneumoniaedirectly. Complement activation results in covalent linkage of the opsonic complement factors C3b and iC3b to theS. pneumoniaesurface which promote phagocytic clearance, along with complement-mediated immune adherence to erythrocytes, thereby protecting against septicaemia. The role of complement for mucosal immunity toS. pneumoniaeis less clear. Given the major role of complement in controlling infection withS. pneumoniae, it is perhaps unsurprising thatS. pneumoniaehas evolved multiple mechanisms of complement evasion, including the capsule, multiple surface proteins, and the toxin pneumolysin. There is considerable variation betweenS. pneumoniaecapsular serotypes and genotypes with regards to sensitivity to complement which correlates with ability to cause invasive infections. However, at present we only have a limited understanding of the main mechanisms causing variations in complement sensitivity betweenS. pneumoniaestrains and to non-pathogenic streptococci.
The reservoir of latent HIV
Authors: Chen Jing , Zhou Tong , Zhang Yuan , Luo Shumin , Chen Huan , Chen Dexi , Li Chuanyun , Li Weihua
Published: July 2022

The persistence of latent reservoir of the human immunodeficiency virus (HIV) is currently the major challenge in curing HIV infection. After HIV infects the human body, the latent HIV is unable to be recognized by the body’s immune system. Currently, the widely adopted antiretroviral therapy (ART) is also unble to eliminate it, thus hindering the progress of HIV treatment. This review discusses the existence of latent HIV vault for HIV treatment, its formation and factors affecting its formation, cell, and tissue localization, methods for detection and removing latent reservoir, to provide a comprehensive understanding of latent HIV vault, in order to assist in the future research and play a potential role in achieving HIV treatment.
Radiotherapy-Induced Cardiotoxicity: The Role of Multimodality Cardiovascular Imaging
Authors: Podlesnikar Tomaž , Berlot Boštjan , Dolenc Jure , Goričar Katja , Marinko Tanja
Published: July 2022

Radiotherapy (RT) is one of the pillars of cancer therapy. High-dose radiation exposure on the thorax is mainly used in the context of adjuvant RT after breast surgery, in lung and esophageal cancer, and as a complement to systemic treatment in lymphoma. Due to the anatomical proximity, the heart inevitably receives some radiation that can result in acute and chronic cardiotoxicity, leading to heart failure, coronary artery disease, pericardial and valvular heart disease. Current evidence suggests there is no safe radiation dose to the heart, which poses a need for early recognition of RT-induced cardiac injury to initiate cardioprotective treatment and prevent further damage. Multimodality cardiac imaging provides a powerful tool to screen for structural and functional abnormalities secondary to RT. Left ventricular ejection fraction, preferably with three-dimensional echocardiography or cardiovascular magnetic resonance (CMR), and global longitudinal strain with speckle-tracking echocardiography are currently the key parameters to detect cardiotoxicity. However, several novel imaging parameters are tested in the ongoing clinical trials. CMR parametric imaging holds much promise as T1, T2 mapping and extracellular volume quantification allow us to monitor edema, inflammation and fibrosis, which are fundamental processes in RT-induced cardiotoxicity. Moreover, the association between serum biomarkers, genetic polymorphisms and the risk of developing cardiovascular disease after chest RT has been demonstrated, providing a platform for an integrative screening approach for cardiotoxicity. The present review summarizes contemporary evidence of RT-induced cardiac injury obtained from multimodality imaging—echocardiography, cardiovascular computed tomography, CMR and nuclear cardiology. Moreover, it identifies gaps in our current knowledge and highlights future perspectives to screen for RT-induced cardiotoxicity.