bluuebunny/crossref_metadata_2025 huggingface dataset:
Interaction between COX-1 and COX-2 increases susceptibility to ischemic stroke in a Chinese population
Authors: Zhao Lei , Fang Jinghuan , Zhou Muke , Zhou Jie , Yu Lihua , Chen Ning , He Li
Published: October 2019

Background:Mutations of cyclooxygenase gene (COX gene) may increase the susceptibility of ischemic stroke. We investigated five variants (rs5788, rs1330344, rs3842788, rs20417, and rs689466) of two COX genes in order to explaining the association between these polymorphisms and we also investigated the association between these variants and ischemic stroke risk to determine whether gene–gene interaction between these genes increases the susceptibility of ischemic stroke or its subtypes.
Method: A total of 1981 study subjects (1078 cases and 903 control subjects) were recruited. The interaction of multiple factors was investigated using Multifactor Dimensionality Reduction. The additive effect of single nucleotide polymorphisms on ischemic stroke or its subtypes were analyzed by multiple factor logistic regression.
Results: At COX-1(rs1330344), AA genotype carriers had a lower susceptibility of ischemic stroke ( OR=0.657, 95%CI= 0.437-0.988, P = 0.044 ), and A allele carriers had a lower susceptibility of ischemic stroke ( OR=0.812, 95%CI= 0.657-0.978, P = 0.029 ). At COX-1(rs3842788), AA genotype carriers had a higher susceptibility of ischemic stroke ( OR =5.203, 95% CI=1.519-5.159, P =0.016) . At COX-2 (rs689466), AA genotype carriers had a higher susceptibility of large-artery atherosclerosis ( OR =1.404, 95% CI=1.019-1.934, P =0.038 ). COX-1(rs1330344, rs3842788) and COX-2 rs689466 interacted in SVO, but had no additive effect with ischemic stroke and other subtypes.
Conclusions: At rs1330344, AA genotype may reduce the susceptibility of ischemic stroke. At rs3842788, AA genotype may increase the susceptibility of ischemic stroke. At rs689466, AA genotype may increase the susceptibility of large-artery atherosclerosis (LAA). COX -1(rs1330344, rs3842788) and COX-2 rs689466 interacted in small vessel occlusion (SVO), but had no additive effect with ischemic stroke and other subtypes.
South and Central America Cut Flower Production and Postharvest Survey
Authors: Loyola Cristian E. , Dole John M. , Dunning Rebecca
Published: October 2019

Imports of cut flowers into the United States have doubled in the last 20 years and come mainly from Colombia and Ecuador. We surveyed the cut flower industry in South and Central America, focusing on Colombia and Ecuador, to determine their production and postharvest problems. We received a total of 51 responses, of which 62% of the respondents had 100 or more employees. The most commonly grown or handled crops were rose (Rosa hybrids), carnation (Dianthus caryophyllus), chrysanthemum (Chrysanthemum ×grandiflorum), alstroemeria (Alstroemeria cultivars), gerbera (Gerbera jamesonii), and hydrangea (Hydrangea species), in order of ranking. The most significant production problem was insect management, with disease management and crop timing the next most important issues. The most important species-specific issues in production were phytosanitary problems, disease (causal organism not specified), leaf miner (Lepidoptera, Symphyta, or Diptera), and thrips (Thysanoptera). The main overall postharvest problem was temperature management, followed by hydration and flower food management and botrytis (Botrytis cinerea). In regard to on-farm postharvest handling, damage to the flowers was the most mentioned issue. For the postharvest during storage and transport phase, temperature management, air transport, damage, and botrytis were the most important problems. The most mentioned customer complaints were damage, botrytis, and phytosanitary problems. The results of this survey can be used by researchers to focus their work on topics of most need. Improved production and postharvest handling will support the continued growth of the cut flower industry.
Molecular characterization of OsCURT1A from upland rice in response to osmotic stress
Authors: Toni Bernadette , Isa Nurulhikma Md , Tan Cheng Seng , Ismail Ismanizan , Zainal Zamri
Published: October 2019

CURT1 proteins in Arabidopsis thaliana have been reported to be important for inducing grana curvature. Currently, we have identified transcript encoding CURT1A from Oryza sativa cv. indica through RNA-seq analysis and characterised using heterologous system in Arabidopsis. The OsCURT1A gene shares 80% of its amino acid sequence with Arabidopsis AtCURT1A. Phylogenetic analysis revealed that the OsCURT1A is also closely related to the CURT1 proteins in other choloroplast- conatining organisms. In silico analysis of OsCURT1A promoter shows that several cis-elements related to stress are present in the 5' upstream from the coding region. Under normal conditions, there were no notable changes in the phenotype and chlorophyll a;b ratio between three Arabidopsis genotypes, which were overexpressed (35S::OsCURT1A), T-DNA insertional mutant line (atcurt1a), and Wild type (Col-0). However, overexpression of OsCURT1A under salinity condition demonstrate high chlorophyll a:b compared to Col-0, whereas, the lack of atcurt1a gene in the mutant line showed reduced chlorophyll a:b ratio. These results indicate that the OsCURT1A might have a function as salt-stress related gene, which may indirectly regulate the chlorophyll a:b ratio. Therefore, OsCURT1A can be used as a potential candidate for salinity stress tolerance in crop improvement.
KEBERAGAMAAN EKS PENDERITA KUSTA DAN PENGEMBANGAN METODE DAKWAHNYA DI PERKAMPUNGAN REHABILITASI KUSTA DONOROJO JEPARA
Authors: Muslimah Muslimah
Published: October 2019

Patients with leprosy or ex leprosy have a complex problem. They blame the god for his illness, try to suicide and hide from society. From the complex problem of ex leprosy, required the ex leprosy get special dakwah method . da’i must apply exact dakwah method and finally dakwah can be solve a problem and can be increase of religiosity. This research use a qualitative method. The result from this research indicate is ex leprosy have a good religiosity, in belief a god dimension, knowlage dimension and experience dimension. Development of variation da’wa not increase yet all of the religiosity dimension.

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Penderita kusta maupun eks penderita kusta mempunyai masalah yang kompleks. Mereka cenderung menyalahkan Tuhan atas keadaannya, mencoba bunuh diri dan bersembunyi secara sosial. Kompleksnya permasalahan yang dihadapi eks kusta menjadikan eks kusta membutuhkan metode khusus dalam meyampaikan pesan dakwah. Da’i harus menentukan metode dakwah yang tepat, sehingga pada akhirnya model dakwah yang diterapkan mampu memecahkan problem yang dihadapi karena penyakitnya dan meningkatkan pemahaman agama. Jenis penelitian ini kualitatif deskriptif. Hasil penelitian ini menunjukkan bahwa eks kusta mempunyai keberagamaan yang baik pada aspek keyakinan,pengetahuan dan konsekuensi. Pengembangan metode dakwah dilakukan melalui variasi belum mampu meningkatkan seluruh aspek keberagamaan.
DAKWAH ISLAM DENGAN PENDEKATAN BIMBINGAN DAN KONSELING
Authors: Prihatiningtyas Siti
Published: October 2019

Humans need the help of others in solving their life problems. Life problems always develop, along with the times. The problems faced by humans also change. This change provides a treatment from various parties, including da'wah as an alternative way to solve human problems. Da'wah with various elements has responsibility in solving human problems. Da'wah is carried out by various means, one of which is guidance and counseling, both of which are used as references in carrying out da'wah. Something that is needed now is to increase the role of da'wah with guidance and counseling, so as to be able to solve human problems. This article focuses on the elaboration of guidance and counseling in solving human problems within the framework of da'wah

 

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Manusia memerlukan bantuan orang lain dalam menyelesaikan persoalan hidupnya. Persoalan kehidupan selalu berkembang, seiring dengan perkembangan zaman. Persoalan yang dihadapi manusia juga mengalami perubahan. Perubahan ini memberikan sebuah perlakuan dari berbagai pihak, termasuk dakwah sebagai alternatif jalan menyelesaikan masalah manusia. Dakwah dengan berbagai unsurnya mempunyai tanggungjawab dalam menyelesaikan persoalan manusia. Dakwah dilakukan dengan berbagai jalan, salah satunya adalah bimbingan dan konseling, Kedua hal ini dijadikan sebagai referensi dalam melaksanakan dakwah. Sesuatu yang dibutuhkan saat ini adalah meningkatkan peran dakwah dengan bimbingan dan konseling, sehingga mampu menyelesaikan masalah manusia. Artikel ini fokus pada elaborasi bimbingan dan konseling dalam menyelesaikan persoalan manusia dalam kerangka dakwah.
Interception of sediment-liberated phosphate in a surface aquatic system for eutrophication control
Authors: Gao Ge , Yang Shengjiong , Xu Huining , Dzakpasu Mawuli , Jin Pengkang , Wang Xiaochang C.
Published: October 2019

Phosphorus internal loading from the sediment of a surface aquatic system is considered to be the primary source of phosphorus responsible for eutrophication. In this study, we propose a possible solution to intercept phosphorus liberated from sediment to overlying water by a membranous nano-barrier (MNB) with tunable capacity. The equilibrium could be attained within 2 h when the MNB interacted with phosphate-containing water. The intercepting capacity was almost unaffected when the solution pH was varied from 4 to 10. The laboratory-scale trial showed that the MNB could positively intercept phosphorus liberated from sediment when the MNB covered the sediment, and the MNB was easy to replace once it became phosphate saturated, making its actual application feasible. Generally, the novel MNB can be considered to be a possible pathway for eutrophication control in shallow surface aquatic systems and scenic water.
Práticas pedagógicas e ensino integrado
Authors: Araujo Ronaldo Marcos de Lima , Frigotto Gaudêncio
Published: October 2019

Trata-se, nesse artigo, de práticas pedagógicas articuladas ao projeto de ensino integrado. Por meio de pesquisa bibliográfica e tendo como referência principal educadores marxistas, em particular, Pistrak (2009), problematizam-se possíveis soluções apenas didáticas para o projeto de ensino integrado e afirma-se que o desenvolvimento de práticas pedagógicas integradoras requer, principalmente, soluções ético-políticas. Sustenta-se que o essencial é vincular o ensino ao trabalho real dos alunos, valorizando a sua auto-organização e requerendo uma atitude humana transformadora. Com base nessas referências, são sistematizadas orientações para ação didática integradora valorizando o trabalho coletivo, a problematização e auto-organização como estratégias principais para a formação dos sujeitos solidários, críticos e autônomos.
A formação universitária como bem público
Authors: Bissoto Maria Luísa , Begnami Maria Luiza Vechetin
Published: October 2019

O Estado neo liberal traz consequências para a integridade das instituições sociais e as do ensino superior. Objetiva-se analisar uma consequência em especial: a corrosão da ideia de bem público, abarcando questões de justiça social e de equanimidade. Considera-se como a formação universitária é afetada por essa corrosão e o papel da Universidade na sua reconstrução. Metodologicamente, está fundamentada na perspectiva da ética do cuidado,no âmbito da Teoria Histórico-Cultural da Atividade. Tais bases teóricas favorecem a (re)interpretação epistemológica do fazer pedagógico universitário, propondo que a Universidade encontre sua razão de ser imiscuída nas questões essenciais do seu tempo.
Livros didáticos brasileiros e as ideias sobre direitos humanos, paz e pacifismo (1940-2000)
Authors: Gatti Júnior Décio , Gatti Giseli Cristina do Vale
Published: October 2019

Este artigo visa conhecer os valores pacifistas contidos em livros didáticos brasileiros entre 1940 e 2000. Livros que, segundo Chervel (1990), são portadores de finalidades educacionais. Foram analisadas obras referentes à História Geral e do Brasil, à Educação Moral e Cívica e à Organização Social e Política do Brasil (OSPB). Constatou-se que, entre 1940 e 1970, conjugavam-se ideário liberal e formação moral cristã. Na década de 1980, houve iniciativas originais na disciplina de OSPB. Nas décadas de 1990 e 2000, apesar de maior adesão à Doutrina do Direitos Humanos e à Educação para a Paz, houve enfraquecimento da temática nos livros didáticos.
Educação jesuítica na América Portuguesa: a dispensa das leis positivas e a racionalidade mercantil
Authors: Costa Célio Juvenal , Oliveira Anderson dos Santos de
Published: October 2019

O objetivo deste artigo é determinar a plausibilidade de nossa tese de que as solicitações da dispensa das leis positivas, presentes nas cartas jesuíticas enviadas da América Portuguesa no século XVI, demonstram que a atuação dos missionários, no Brasil quinhentista, além de seus fins religiosos, foi marcada, também, pela racionalidade mercantil. Defende-se, assim, que os jesuítas agiam antenados às contingências daquela realidade europeia, lusa e brasílica. Ao espírito reformista somava-se a mentalidade mercantil, que dava à missão a feição de empreendimento religioso, na qual a lógica de se ter lucros espirituais direcionou a práxis daqueles mercadores de almas.
Direito à educação, formação do adolescente e adoecimento docente no Estado capitalista
Authors: Campos Herculano Ricardo , Leal Záira Fátima de Rezende Gonzalez , Facci Marilda Gonçalves Dias
Published: October 2019

A educação, não obstante ser considerada direito humano universal, e contemplada na legislação nacional e internacional, tem sua efetivação enquanto política pública marcada por significativa distância entre o direito instituído e o direito efetivado, expressão das contradições que caracterizam o Estado capitalista. Tomando essa assertiva como ponto de partida e valendo-se do referencial do materialismo histórico-dialético, como formulado por Marx e Engels, e da Psicologia Histórico-Cultural, estruturada a partir de Vygotsky, Luria e Leontiev, o presente artigo visa problematizar a distância entre o que prevê a legislação e o que é efetivamente implementado na sociedade, privilegiando a reflexão sobre os efeitos de tal situação na vida de alunos/adolescentes e professores.Revela-se a constituição e a feição de classe que marcam o Estado e sua íntima relação com as características que assumem as políticas públicas; a falta de preparo das escolas para efetivar uma formação coerente com o desenvolvimento de alunos adolescentes; e o adoecimento dos professores em face da impotência, e da cobrança, para lidar com questões para as quais não se sentem preparados.
Syntheses and Biological Activities of triazole-based Sulfonamides
Authors: Ramazani Ali , Sadighian Hamed , Gouranlou Farideh , Joo Sang W.
Published: October 2019

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The triazole and sulfonamide compounds are known as biologically active agents that were employed for medicinal applications. These compounds were obtained in different forms by a variety of techniques to vast ranges of applications. The broad biological properties of these compounds have encouraged researchers to design and synthesize triazole-based sulfonamide derivatives as compounds with potential biological activity. In this review, we summarized the synthetic procedures of triazole-based sulfonamide compounds together with their biological activities during the last two decades.
Molecular Hybridization as a Tool in the Design of Multi-target Directed Drug Candidates for Neurodegenerative Diseases
Authors: Gontijo Vanessa Silva , Viegas Flávia P. Dias , Ortiz Cindy Juliet Cristancho , de Freitas Silva Matheus , Damasio Caio Miranda , Rosa Mayara Chagas , Campos Thâmara Gaspar , Couto Dyecika Souza , Tranches Dias Kris Simone , Viegas Claudio
Published: October 2019

Neurodegenerative Diseases (NDs) are progressive multifactorial neurological pathologies related to neuronal impairment and functional loss from different brain regions. Currently, no effective treatments are available for any NDs, and this lack of efficacy has been attributed to the multitude of interconnected factors involved in their pathophysiology. In the last two decades, a new approach for the rational design of new drug candidates, also called multitarget-directed ligands (MTDLs) strategy, has emerged and has been used in the design and for the development of a variety of hybrid compounds capable to act simultaneously in diverse biological targets. Based on the polypharmacology concept, this new paradigm has been thought as a more secure and effective way for modulating concomitantly two or more biochemical pathways responsible for the onset and progress of NDs, trying to overcome low therapeutical effectiveness. As a complement to our previous review article (Curr. Med. Chem. 2007, 14 (17), 1829-1852. https://doi.org/10.2174/092986707781058805), herein we aimed to cover the period from 2008 to 2019 and highlight the most recent advances of the exploitation of Molecular Hybridization (MH) as a tool in the rational design of innovative multifunctional drug candidate prototypes for the treatment of NDs, specially focused on AD, PD, HD and ALS.
Traditional Herbal Medicines, Newer Herbs and Other Novel Approaches Integrated in Herbal Medicine for Atopic Dermatitis-A Narrative Review
Authors: Kumar Pravin , Sharma Dinesh Kumar , Ashawat Mahendra Singh
Published: October 2019

Atopic Dermatitis (AD) is a prolonged reverting skin ailment with characteristically distributed
skin lesions. In the previous decades, researchers had shown a marked interest in AD due to
its increased prevalence in developed countries. Although different strategies including biological
and immune modulators are available for the treatment of AD, each has certain limitations. The
researchers had shown considerable interest in the management of AD with herbal medicines. The
establishment of herbal drugs for AD might eliminate local as well as systemic adverse effects associated
with long term use of corticosteroids and also higher cost of therapy with biological drugs.
The present review discusses the traditional East Asian herbal medicines and scientific data related
to newer herbal extracts or compositions for the treatment of AD. In vivo animal models and in
vitro cell cultures, investigated with herbal medicines to establish a possible role in AD treatment,
have also been discussed in the paper. The paper also highlights the role of certain new approaches,
i.e. pharmacopuncture, a combination of allopathic and herbal medicines; and novel carriers
(liposomes, cubosomes) for herbal drugs on atopic skin. In conclusion, herbal medicines can be a
better and safe, complementary and alternative treatment option for AD.
Oral Bioavailability Enhancement of Amisulpride: Complexation and its Pharmacokinetics and Pharmacodynamics Evaluations
Authors: B. Prajapati Jagruti , K. Sawant Krutika , Dubey Bhramanand
Published: October 2019

Background:

Many CNS drugs have low bioavailability due to their poor water solubility of
extensive first-pass metabolism and hence have less effectiveness.

Objective:

The present study aims to enhance the solubility and oral bioavailability of poorly watersoluble
antipsychotic drug Amisulpride (AMS) through complexation with 2-hydroxypropyl β-
cyclodextrin (HPβCD). It has slow and erratic absorption after oral administration.

Methods:

This report describes the study of the phase solubility diagram, preparation of the inclusion
complex and tablet of prepared inclusion complex, characterization of the physico-chemical properties
of the inclusion complex and tablet.

Results:

In-vitro study (100 % drug release in 15 minutes), and in-vivo study of an AL-type (linear type)
phase solubility diagram indicated a complex of AMS-HP-β-CD with the constant complex formation
of 13245 M−1 at 37°C. The complex formation was confirmed by DSC, IR, and X-ray diffraction. The
extent of absorption of the complex was determined in rats and was compared with that of pure drug
and the market product. The peak plasma concentration of pure drug was 30.05 ± 1.3 ng/ml (Cmax) at 60
± 3 min, whereas with the market product the value was 54.85 ± 1.2 ng/ml at 40 ± 1 min and with
AMS-HPβCD inclusion complex the value was 79.01 ± 1.5 ng/ml. The AUCtot of the pure drug was
2980.34±3.6, the market product was 7238.73±2.9 and of the inclusion complex was 11871.1±2.8.

Conclusion:

Pharmacodynamic studies in mice showed improved effectiveness of drug compared to
pure drug. The oral bioavailability of AMS was improved from 48% to 78%.
Supersnelle trein voor Nederland vooral van psychologisch belang
Authors: Van Hagen Mark , De Vries Mark
Published: October 2019

Sinds de jaren zestig bestaan er plannen om een net van supersnelle treinenaan te leggen tussen de grote steden in Noordwest-Europa. Het succes van deFranse TGV-trein leidde recent tot een meer serieuze belangstelling. Dezebelangstelling wordt nog versterkt door de mogelijkheid via een kanaaltunnel ookEngeland op dit nieuwe Europese treinennet aan te sluiten. Wat zullen de gevolgenvan zo'n TGV-net zijn voor de stedelijke structuur van Noordwest-Europa?En, van belang voor Nederland, wat zal er gebeuren als de Randstad niet opdat net wordt aangesloten?
AGORANOMI
Authors: REDACTIE AGORA
Published: October 2019

Deze rubriek staat open voor iedereen die op het gebied vande ruimtelijke ordening Iets wil aankondigen. verslaan ofbespreken. Ook reacties op in Agora geplaatste artikelen zijnwelkom. Kopij sturen naar redactie. zie colofon op bladzijde 3.
Een goed vervoersprodukt betekent in eerste instantie het afstemmen van dienstregelingen
Authors: Groot Linda , Witsen Peter Paul , Zomerplaag Jos
Published: October 2019

In het thema komen deze keer verschillendevormen van openbaar vervoeraan bod. De rit begint bij stadsvervoerderde Rotterdamse Electrische Tram(RET) en de Nederlandse Spoorwegen(NS). Onderweg wordt gestopt bij deNoord-Zuid-Hollandse vervoermaatschappij(NZH) en kijken we naar deontwikkelingen met betrekking tot deHoge Snelheidslijn (HSL). Verder komenhet Verenigd Streekvervoer N ederland(VSN) en de vereniging BOVAGRAIaan het woord en gaan we in op hetvervoersgedrag van recreanten.
DE-KULTURALISASI ISLAM DAN KONFLIK SOSIAL DALAM DAKWAH WAHABI DI INDONESIA
Authors: Hamdi Saipul
Published: October 2019

This article investigates the phenomena of a transnational Wahhabi movement particularly the Wahhabi local organization in Indonesia. Wahhabism is a puritan, textual, and reformist Islamic movement established in Nejd Saudi Arabia 18th century identified as part of the conservative Sunni orthodox tradition. It was determined as the major religious-state reference for shariah law formulation by the Saudi government and expanded to non-Arab countries around the world imposing reformation idea of Islamic religious tradition and academic culture. This article examines the expansion and growth of the Wahhabi local organization in Indonesia and the effort to perform deculturalization of Islam from the local religious tradition practices. Deculturalizing Islam or pulling out Islam from cultural mixture and absorption is not easy because Islam has integrated to the local religious tradition since its presence in the community around the 12th century, which shows a long negotiation and unification of those identities. In doing so, this article explores the response on Wahhabi deculturalization discourse and how the local people negotiate to this new identity and socio-religious transformation influenced by the Wahhabi’s teaching and ideology. The hypothesis of Wahhabi’s teaching position and role in shaping radicalism and terrorism has carried this research to understand the local context of Wahhabi in Indonesia, how the Wahhabi people understand and engage to radicalism and terrorism, the response to global jihadism propagation including Al-Qaeda and ISIS, and the production of Khilafah Islamiyah idea and mission. The aggressive approach of Wahhabi, which attacks a belief system of local Muslim practices and invigorates the new single identity of Islam, leads this article to investigate the patterns of Wahhabi socio-religious conflict in the communities and the influence to social disintegration existence.
RELIGIOUS BLASPHEMY AND MONITORY SOCIETY IN INDONESIAN DIGITAL AGE
Authors: Epafras Leonard Chrysostomos , Kaunang Hendrikus Paulus , Asri Syamsul
Published: October 2019

The present article is a research report on the discourse of religious blasphemy in connection with digital practices in Indonesia. It sought to understand the shift of public participation in shaping the discourse that understood within the framework we identified as “monitory society.” The research employed qualitative approach by using several methods, among others are interview and social media observation. Reflecting upon the current national trends and new shift of political landscape, it appeared that religious blasphemy immersed into the political discourse as weaponized information, hence disrupted the meaning of democracy in digital age, as once become the rhetoric of digital technology. In general, the discourse of religious blasphemy in Indonesia is dealing with public piety and social order. It concerned more on religious boundary rather than the improvement of religious lives and personal piety.
La evaluación clínica objetiva estructurada desde el área de formación médica general
Authors: Gómez-Peña Luis , Dávalos Espinosa Litzi Gabriela , Rodríguez Prieto Paul Fernando , Blanco Zabala Elizabeth , Viera Hernández Raiza Verónica , Rocha Cisneros Ivonne De la Caridad
Published: October 2019

Introducción: Desde hace unos años, la educación asiste a cambios en la formación. Se intenta pasar de una formación basada en la adquisición pasiva de conocimientos teóricos, a otra formación más activa, dinámica y reflexiva. La forma ideal de evaluar la capacidad profesional es observar qué hace el médico ante las situaciones habituales en su consulta. Como esto entraña grandes dificultades técnicas, se han diseñado instrumentos que se aproximan bastante a la realidad, como la evaluación clínica objetiva estructurada. 

Objetivo: El objetivo fue aplicar una evaluación clínica objetiva estructurada para valorar las habilidades clínicas en estudiantes de quinto semestre. 

Método: Se conformó un comité de prueba con 4 docentes del área de formación médica general. Se realizó una tabla de especificaciones de habilidades clínicas para evaluar a los estudiantes con los casos clínicos planificados, fueron incluidas la anamnesis, examen físico, juicio clínico, diagnóstico anatofisiológico, habilidades imagenológicas y comunicación terapéutica. Se diseñaron 4 estaciones, se validó a través del juicio de expertos su contenido y se calculó la validez predictiva de las listas de cotejo. Se aplicó la prueba a 17 estudiantes, se validó el instrumento, se obtuvieron resultados de la estadística descriptiva y se calculó el alfa de Cronbach. 

Resultados: El análisis de concordancia del instrumento de evaluación según los expertos, fue aceptable, pues la condición de esencial superó el 80%; la validez predictiva y el alfa de Cronbach en 3 de las estaciones fue significativo, la cardiopatía chagásica fue la mejor evaluada con 97.5 y el alfa de Cronbach general fue de 0.507. 

Conclusiones: Los instrumentos utilizados en la evaluación clínica objetiva estructurada tienen la validez y confiabilidad suficiente para ser aplicados en el contexto investigativo y mejorar la calidad de las evaluaciones clínicas, haciéndolas más objetivas y con mayores posibilidades de retroalimentación en el proceso de aprendizaje.
Noticias sobre tres apostolados pictóricos del primer tercio del siglo xviii localizados en la ciudad de Durango
Authors: Martínez Romero Adolfo
Published: October 2019

Afortunadamente, dentro de los territorios norteños se siguen encontrando obras pictóricas del periodo virreinal, sobre todo del siglo XVIII, lo cual continúa engrosando el conocimiento que se tiene de los pintores activos durante esa centuria. Éste es el caso de los lienzos que forman parte de tres apostolados: uno firmado por Ventura Miranda, otro de Nicolás Correa y uno más de autoría desconocida. Estas pinturas se insertan dentro de las tres primeras décadas del siglo XVIII cuando la ciudad de Durango vivió un auge constructivo y la totalidad de sus templos y conventos se renovaron, lo que requirió de un gran número de obras artísticas para el ornato y la devoción. Finalmente, estos apostolados son la evidencia de los diversos movimientos que han sufrido los acervos virreinales, razón por la que hoy estos lienzos se encuentran en el templo de Nuestra Señora de los Ángeles, construido en la última década del siglo XIX.
Los murales de Tlayacapan
Authors: Arroyo Lemus Elsa Minerva
Published: October 2019

Este artículo presenta el estudio histórico y técnico de la pintura mural del ex convento de San Juan Bautista Tlayacapan (estado de Morelos, México), con el propósito de reconstruir los cambios y alteraciones que han sufrido los programas pictóricos a lo largo del tiempo. Se ha puesto énfasis en los recientes daños provocados por el sismo del 19 de septiembre de 2017 que han modificado el precario estado de conservación de los espacios, llevándolos hasta un punto de “inestabilidad” más cercano a la ruina. En un itinerario inverso que va del fragmento colapsado al conocimiento integral de los espacios originales, hemos desarrollado una metodología propia de los estudios sobre la técnica y los materiales del arte, que se origina en la interrelación de los resultados obtenidos durante el aná-lisis científico de la pintura con las fuentes históricas y las propuestas iconográficas sobre el significado, función y devenir de las imágenes.
Ciência e teatro em quatro atos
Authors: Silveira Joao
Published: October 2019

O livro “Ciência em Cena: teatro no Museu da Vida”, evidencia a reaproximação e simbiose entre arte e ciência em quatro atos, como em uma peça de teatro, e conduz o leitor a explorar as conexões entre teatro, ciência e divulgação científica dentro e fora da Fundação Oswaldo Cruz (Fiocruz), uma relevante instituição de pesquisas brasileira. A obra merece aplausos por retratar com brilhantismo como um sonho feito de ciência e arte se tornou realidade e se destaca como uma referência essencial para compreensão da relação entre teatro e ciência no cenário contemporâneo brasileiro.
A ATUAÇÃO DA ASSOCIAÇÃO DOS ADVOGADOS E ADVOGADAS DE TRABALHADORES RURAIS DA BAHIA: uma reflexão no campo das teorias críticas do Direito
Authors: Souza Maria José Andrade de
Published: October 2019

Fundada num contexto de intensos conflitos no campo agrário baiano, a Associação de Advogados e Advogadas dos Trabalhadores Rurais (AATR), em quase quarenta anos de existência, coincide muitos pontos de sua trajetória com o curso da questão agrária baiana nesse período e constituiu-se numa entidade referenciada no conjunto das assessorias jurídicas populares (AJP) no Brasil. A partir dessa experiência de AJP estabeleceremos um diálogo com as principais tendências que permeiam o campo de práticas jurídicas e políticas da advocacia popular no Brasil – Direito Achado na Rua e Direito Insurgente. A nosso ver, por abordagens distintas, essas tendências tratam a relação dos diferentes interesses no Estado em termos dicotômicos, seja por reduzi-lo à institucionalidade e ao “oficial”, seja por uma leitura tendente à encará-lo como um instrumento da classe dominante, com decorrências nas concepções sobre o Direito e a sua funcionalidade no modelo social capitalista.
A origem medieval da expressão 'língua materna': uma história contra a evidência de sentidos de um termo canônico na reflexão sobre a linguagem
Authors: De Aquino Jose Edicarlos
Published: October 2019

Neste artigo, realizamos um estudo histórico da emergência da expressão “língua materna” no Ocidente, de forma a questionar as evidências formadas em torno desse termo canônico na reflexão sobre a linguagem. Demonstramos assim que a expressão língua materna é uma invenção medieval, empregada inicialmente em latim, nos textos da Igreja, como forma de contrapor essa língua aos vernáculos emergentes. Argumentando que essa expressão não se explica pura e simplesmente pela figura da mulher, mas corresponde primeiramente a certas configurações sociopolíticas na história, mostramos que os primeiros registros da expressão “língua materna” apontam problemas peculiares da sociedade medieval e as questões linguísticas implicadas.
Identidad y lengua en el ciberespacio: ¿existe una conciencia lingüística digital?
Authors: López Muñoz Juan Manuel
Published: October 2019

En el orden del ciberespacio, muchos internautas se denominan a sí mismos nativos o indígenas digitales, constituyendo una nueva comunidad étnica ajena a las fronteras territoriales y culturales del mundo físico, unidos por lo que podríamos llamar una misma “conciencia digital”. En este artículo estudiamos cómo se manifiesta esa conciencia digital a través de las expresiones que los usuarios de Twitter emplean para hablar de quiénes son y qué hacen cuando comunican por ordenador o por otros dispositivos conectados a la red de Internet.  Nuestro objetivo es intentar sistematizar algunas características específicas de la lengua digital, con el fin de proponer algunas pistas para la pedagogía de la lengua digital y participar en el debate de “buen uso” de la lengua digital en el marco de la cortesía digital.------------------------------------------------------------------------------------------IDENTIDADE E LÍNGUA NO CIBERESPAÇO: EXISTE UMA CONSCIÊNCIA LINGUÍSTICA DIGITAL?Na ordem do ciberespaço, muitos internautas se autodenominam nativos ou indígenas digitais, constituindo uma nova comunidade étnica fora das fronteiras territoriais e culturais do mundo físico. Eles têm em comum o que poderíamos chamar de a mesma "consciência digital". Neste artigo, estudamos como essa consciência digital se manifesta por meio das expressões que os usuários do Twitter empregam para falar sobre quem são e o que fazem quando se comunicam por computador ou outros dispositivos conectados à rede da Internet. Nosso objetivo é tentar sistematizar algumas características específicas da linguagem digital, a fim de propor algumas pistas para sua pedagogia e participar do debate do "bom uso" da linguagem digital no contexto da cortesia digital.---Original  em espanhol.
Temas de política linguística no processo de integração regional, una reseña
Authors: Rizzo María Florencia
Published: October 2019

Reseña de [resenha de]:SOUSA, Socorro Tavares de; ROCA, María del Pilar; PONTE, Andrea Silva (orgs.). Temas de política linguística no processo de integração regional. Campinas: Pontes, 2018.---Original em espanhol.
TRABALHO, EDUCAÇÃO E REGULAÇÃO JURÍDICA: FORMAS CONTRADITÓRIAS DE SUBSUNÇÃO DO TRABALHO "INFORMAL" AO CAPITAL
Authors: Morais Ricardo Cavalcante
Published: October 2019

Das relações trabalho-capital decorrem contradições que se manifestam naquestão social, da qual deriva a “informalidade” que, a princípio, se manifestapredominantemente em situações improdutivas ao capital. Contudo, na medida emque a reestruturação produtiva do capital se converte em um padrão flexível deacumulação ela passa a integrar também o trabalho produtivo ao capital, o querepercute em uma “nova informalidade” da qual decorre a generalização do trabalho“informal” como forma social dominante de trabalho. No Brasil essas faces da“informalidade” são observadas de um lado, nas atividades da economia popular e deoutro, nos processos de terceirização, “pejotização” e “uberização” do trabalho,assegurados pela reforma trabalhista de 2017 e outros diplomas legais.
MEMÓRIA, EDUCAÇÃO E RESISTÊNCIA NA BAHIA: A COMISSÃO MILTON SANTOS DE MEMÓRIA E DE VERDADE
Authors: Magalhães Lívia Diana Rocha , De Souza Daniela Moura Rocha
Published: October 2019

O grupo de estudos e pesquisa em História e Memória Geracional e trajetóriassóciogeracionais – GHEMPE, sediado no Museu Pedagógico da UESB, desenvolve apesquisa “Educação, Memória e História da Bahia: processos autoritários e ditaduramilitar” tendo como norte o levantamento de documentos que dão suporte aoentendimento acerca dos processos autoritários que recaíram sobre estudantes,professores (as) e funcionários (as), baianos (as) durante a ditadura civil-militar(1964 - 1985).
METODOLOGÍAS DESDE LOS MOVIMIENTOS SOCIALES: UNA PEDAGOGÍA QUE “NO CONCIENCIA”, PERO TRANSFORMA CON LA GENTE
Authors: Villasante Tomás R.
Published: October 2019

Se critican los intentos concienciadores desde las vanguardias auto-proclamadas. Se ofrece un esquema de cómo son las relaciones de comunicación actuales y unas posibles estrategias con “conjuntos de acción” que venimos practicando desde las metodologías participativas. La construcción de la conciencia social parte de lo biológico y pre-consciente en los ciclos vitales básicos, y mediante “ritos de paso” construye las conciencias colectivas en las que nos movemos. Se acaba proponiendo trabajar con “grupos motores” en las democracias participativas.
Sedat Veyis Örnek'in Öykülerinde Kadının Görünümü
Authors: Üstün Koray
Published: October 2019

Sedat Veyis Örnek (1929-1980), folklor üzerine yaptığı çalışmalarla iz bırakmış bir bilim insanıdır. Örnek, akademik çalışmaların yanı sıra gençlik yıllarından itibaren edebiyatla da ilgilenmiş; lise yıllarında başladığı öykü denemelerini uzun yıllar sürdürmüştür. Bu öykülerde gözlem ve tahlil gücünü yansıtan betimlemeler dikkat çekmektedir. Yazar, gerek olay gerek durum merkezli kurguladığı öykülerinde merkeze insanı alarak yerilen, yüceltilen, zayıflıkları ve güçlülükleriyle farklı perspektiflerden okunabilen anlatıcılar yaratmıştır. Bu anlatıcılar kendi dünyalarını sunarken genellikle kadını bedensel bir meta olarak algılayarak eril bir söylemle bedensel arzu nesnesi olarak tarif etmişler; mekânın anlatıcı üzerindeki izlenimleri sırasında doğan panoramanın bir parçası şeklinde çizmişlerdir. Halkbilimci duyarlılığıyla edindiği izlenimleri, bilimsel çalışmalarının yanı sıra yazınsal faaliyetlerinde de bir kaynak olarak kullanan Sedat Veyis Örnek’in öyküleri kadın kimliği odağa alınarak okunduğunda yazarın, başarılı gözlemlerini kurguladığı eril anlatıcı aracılığıyla sunduğu görülmektedir. Örnek, şehir ve savaş izleklerini barındıran pek çok ögeyi kullanarak kaleme aldığı anlatılarında mekânla birlikte değerini yitiren insanlığı kadın kimliği üzerinden somutlaştırmıştır.
Evaluación del desempeño por competencias
Authors: Párraga-Zambrano Lenin
Published: October 2019

La investigación fue de carácter descriptivo con el objetivo de analizar el desempeño del talento humano de la cooperativa de suministros tecnológicos de Manabí.  El 65% de los encuestados no recibe comentarios referentes a su propio desempeño lo cual demuestra que la organización no es consciente del rol primordial que representan sus recursos humanos en desarrollo para fortalecer su desempeño, es decir que en dicha organización no se valora el recurso humano como ente proveedor que permite alcanzar los objetivos individuales relacionados directa o indirectamente con la organización.  La evaluación del desempeño valora sistemáticamente el desempeño que posee cada persona en función de las actividades que cumple y de las metas y resultados a alcanzar ya que la misma debe realizarse siempre con proporción al perfil del puesto que ocupa para luego poder dar la retroalimentación y comentar los progresos del evaluado.
CONTROL SYSTEM OF TECHNOLOGICAL SAFETY OF INDUSTRIAL PROCESSES BASED ON MULTIAGENT MODELING
Authors: Bakasov Sabir Rumovich , Voronin Yuri Anatolievich , Bogatikov Valery , Prorokov Anatoly , Sanaeva Galina
Published: October 2019

The paper focuses on the intellectual organization of technological security management in conditions of uncertainty and rapid changes in the industrial processes. Application of artificial intelligence methodologies, namely, agent technology increases the self-organization potential in the industrial system and helps to increase the efficiency in decision making. Intellectualization of organizational and technological systems should stimulate the enterprise’s interest in the development of its knowledge system, in positive ways of finding solutions to critical situations. It becomes necessary to search solutions for both methodological and new theoretical approaches to designing a control system for such organizational and technological entities. Such approaches are usually based on adaptation and self-organization principles. Currently, the main tool for the intellectualization of industrial organizational and technological systems is agent-oriented technology for building control systems. Usually, an agent is a high-level abstraction that is given certain functionality. Functionality depends on the range of tasks that this element needs to solve when working with the system as a whole. To maintain a leading position in complex technology management processes, it is necessary to use an innovative approach to the intellectualization of enterprise management tools. One of such innovative tools could be the concept of intellectualization of management, the centerpiece of which is the intellectual capital of the enterprise making the basis for its further sustainable development and effective functioning.
Hacia la novela de la democracia: relevo generacional y debate estético en Ínsula 1966-1985
Authors: Castro Díez Asunción
Published: October 2019

Este artículo estudia la recepción que la revista Ínsula hizo de los cambios estéticos que se dieron en la narrativa española entre 1966 y 1985. Concretamente, se centra en la aparición de una nueva promoción de escritores, conocidos como “Generación del 68” o “Generación del 75”, que empiezan a publicar sus novelas desde finales de los años 60.  En esos años, el panorama literario español estaba dominado por la confrontación entre dos estéticas: realismo y tradición frente a experimentalismo y renovación. Pero los jóvenes escritores ya no están interesados en esta dialéctica, no se ajustan a un único modelo narrativo y presentan modalidades muy diferentes, en una concepción abierta y plural del género que es bien valorada en la revista.
Autoeficacia académica en estudiantes de Psicología de una universidad de Lima
Authors: Dominguez-Lara Sergio , Fernández-Arata Manuel
Published: October 2019

El objetivo de este estudio descriptivo fue conocer la prevalencia de baja Autoeficacia Académica (AA) en estudiantes de una universidad privada de Lima (Perú). Participaron 730 estudiantes de Psicología (76.6% mujeres) de entre 16 y 47 años (M = 20.72) de 1o. a 5o. año, quienes fueron evaluados con la Escala de Autoeficacia Percibida Específica de Situaciones Académicas. Los análisis preliminares estuvieron basados en métodos analítico-factoriales orientados a explorar la equivalencia de la medida de AA de acuerdo al sexo y año de estudios. Los resultados indican que el 17.4% presenta baja AA, el 61.2% AA promedio y un 21.4% reporta altos niveles de AA. Los hombres reportan mayor AA que las mujeres y los estudiantes de 5o. año indican más AA que los de 1o.
Les conséquences des politiques de régulation par délégation de pouvoirs à des agences indépendantes
Authors: Grandjean Olivier
Published: October 2019

Regulation of European markets has changed considerably since 1980. As a result of factors such as European integration, international forces, and the decline of the welfare state, European governments have opted for other development strategies. Most notably, there has been a movement to privatize state-owned industries, as well as to develop new constitutive rules of competition that aim to ensure market competition in order to both obtain optimal economic efficiency and most efficiently allocate resources. The economic role of the European Union has thus been reinforced accordingly. Moreover, an indirect form of government in such matters has also emerged. These strategies have ultimately developed into a new form of government, which is characterized by changes in the official functions, institutions, actors and the types of policies followed on the matters.[...]
PENERAPAN MODEL PEMBELAJARAN POE (PREDICT, OBSERVE, EXPLAIN) TERHADAP HASIL BELAJAR SISWA KELAS V DI SDN PANGARANGAN III SUMENEP
Authors: Fahrinnisak Fahrinnisak
Published: October 2019

Tujuan dari penelitian ini adalah: (1) untuk mengetahui keterlaksanaan penerapan model pembelajaran POE  pada pembelajaran IPA terhadap hasil belajar siswa; (2) Apakah penerapan model pembelajaran POE pada pembelajaran IPA dapat meningkatkan ketuntasan hasil belajar siswa; (3) Bagaimanakah aktivitas belajar siswa pada pembelajaran IPA  dengan  menggunakan  model  pembelajaran POE; (4) Bagaimanakah respon belajar siswa setelah mengikuti pembelajaran IPA dengan menggunakan model pembelajaran POE. Penelitian ini dilaksanakan di SDN Pangarangan III Sumenep. Subjek penelitian ini adalah kelas V (lima) dengan jumlah siswa 15 orang. Rancangan penelitian yang digunakan adalah PenelitianTindakanKelas (PTK) yang terdiri dari 2 siklus. Teknik pengumpulan data yang digunakan  antara  lain  :observasi,  tes,  dan  mengisi  angket.  Hasil penelitian menunjukkan bahwa penerapan model POE dapat meningkatkan hasil belajar siswa. Hal ini terbukti dari hasil yang diperoleh yaitu pada siklus I 1,68 menjadi 75,33 pada siklus II. Keterlaksanaan guru pada siklus I 60,3 % dengan kategori sedang menjadi 81,5 % dengan kategori tinggi pada siklus II. Sedangkan keterlaksanaan siswa yaitu pada siklus I 70,15% dengan kategori sedang menjadi 82,05% dengan kategori tinggi pada siklus II. Nilai rata-rata respon siswa pada siklus I 76,67% menjadi 90,67% dengan kategori sangat baik.
Using queuing theory to solve the problem of momentum to issuing the driving licenses in Dohuk city
Authors: Nacy Nabeel G. , Ibrahim Samaher T.
Published: October 2019

Queuing theory is a mathematical study of so-called queues or waiting lines. This phenomenon is common in daily life as in gas stations, airports, repair workshops and other common everyday examples. Waiting occurs when service demand is higher than service system power. Due to the difficulty in predicting the number of customers arriving and the time taken by the customer at the service station, the process of obtaining performance metrics is necessary before the queuing systems are implemented. When the service system power is too high, the system is charged at a high cost. Conversely, when the system power is low (insufficient for the customer service), the waiting time in the queue increases, As well as loss of order to its customers. Therefore, attention has been drawn to the so-called theory of waiting lines to solve such problems to reach a balance in the work of the system.

This research aims to overcome the difficulties experienced by citizens in obtaining market holidays on time and reduce waste in time and the cost of waiting.

The results were as shown in tables (l) to (6) of the city center and according to the distribution of access and service of the model used (G / G / C). We note in the Poisson distribution with exponential that the average number of customers in the system Ls = 5.527), which is approximately (5 customers), which is waiting in the system. We note in the previous distribution itself that the average number of customers in the waiting queue (customer 2.1924 = L q) is approximately 2 (customer) which is waiting in queue. The Poisson distribution with the exponential is that the average time spent by the customer in the system (minute W s = 16.5772). Note in the Poisson distribution with the exponential that the average time spent by the customer in the waiting queue is (minute W = 6.5772) We note in the Poisson distribution with exponential that The average number of customers in the system (customer Ls = 4.3258) is about (4 customers) which is waiting in the system. We see in the previous distribution itself that the average number of customers in the queue (customer 2.0 = L q) ) There is no waiting in the queue. The Poisson distribution with exponential is the average time spent by the customer in the system (min W s = 11.3333). We note in the Poisson distribution with exponential that the average time spent by the customer in the waiting queue is (min W q = 4.6666)