bluuebunny/crossref_metadata_2025 huggingface dataset:
Melatonin Successfully Rescues the Hippocampal Molecular Machinery and Enhances Anti-oxidative Activity Following Early-Life Sleep Deprivation Injury
Authors: Chang Hung-Ming , Lin Hsing-Chun , Cheng Hsin-Lin , Liao Chih-Kai , Tseng To-Jung , Renn Ting-Yi , Lan Chyn-Tair , Chen Li-You
Published: May 2021

Early-life sleep deprivation (ESD) is a serious condition with severe cognitive sequelae. Considering hippocampus plays an essential role in cognitive regulation, the present study aims to determine whether melatonin, a neuroendocrine beard with significant anti-oxidative activity, would greatly depress the hippocampal oxidative stress, improves the molecular machinery, and consequently exerts the neuro-protective effects following ESD. Male weanling Wistar rats (postnatal day 21) were subjected to ESD for three weeks. During this period, the animals were administered normal saline or melatonin (10 mg/kg) via intraperitoneal injection between 09:00 and 09:30 daily. After three cycles of ESD, the animals were kept under normal sleep/wake cycle until they reached adulthood and were sacrificed. The results indicated that ESD causes long-term effects, such as impairment of ionic distribution, interruption of the expressions of neurotransmitters and receptors, decreases in the levels of several antioxidant enzymes, and impairment of several signaling pathways, which contribute to neuronal death in hippocampal regions. Melatonin administration during ESD prevented these effects. Quantitative evaluation of cells also revealed a higher number of neurons in the melatonin-treated animals when compared with the saline-treated animals. As the hippocampus is critical to cognitive activity, preserving or even improving the hippocampal molecular machinery by melatonin during ESD not only helps us to better understand the underlying mechanisms of ESD-induced neuronal dysfunction, but also the therapeutic use of melatonin to counteract ESD-induced neuronal deficiency.
Does the Integration of Pre-Coded Information with Narratives Improve in-Hospital Falls’ Surveillance?
Authors: Lorenzoni Giulia , Rampazzo Roberta , Buratin Alessia , Berchialla Paola , Gregori Dario
Published: May 2021

To evaluate the value added by information reported in narratives (extracted through text mining techniques) in enhancing the characterization of falls patterns. Data on falls notified to the Risk Management Service of a Local Health Authority in Italy were considered in the analysis. Each record reported detailed pre-coded information about patient and fall’s characteristics, together with a narrative description of the fall. At first, multiple correspondence analysis (MCA) was performed on pre-coded information only. Then, it was re-run on the pre-coded data augmented with a variable representing the output analysis of the narrative records. This second analysis required a pre-processing of the narratives followed by text mining. Finally, a Hierarchical Clustering on the two MCA was carried out to identify distinct fall patterns. The dataset included 202 falls’ records. Three clusters corresponding to three distinct profiles of falls were identified through the Hierarchical Clustering performed using only pre-coded information. Hierarchical Clustering with the topic variable provided overlapping results. The present findings showed that the cluster analysis is effective in characterizing fall patterns; however, they do not sustain the hypothesis that the analysis of free-text information improves our understanding of such phenomenon.
Numerical Modeling of Temperature Effect on Tensile Strength of Granitic Rock
Authors: Saksala Timo
Published: May 2021

The aim of this paper is to numerically predict the temperature effect on the tensile strength of granitic rock. To this end, a numerical approach based on the embedded discontinuity finite elements is developed. The underlying thermo-mechanical problem is solved with a staggered method marching explicitly in time while using extreme mass scaling, allowed by the quasi-static nature of the slow heating of a rock sample to a uniform target temperature, to increase the critical time step. Linear triangle elements are used to implement the embedded discontinuity kinematics with two intersecting cracks in a single element. It is assumed that the quartz mineral, with its strong and anomalous temperature dependence upon approaching the α-β transition at the Curie point (~573 °C), in granitic rock is the major factor resulting in thermal cracking and the consequent degradation of tensile strength. Accordingly, only the thermal expansion coefficient of quartz depends on temperature in the present approach. Moreover, numerically, the rock is taken as isotropic except for the tensile strength, which is unique for each mineral in a rock. In the numerical simulations mimicking the experimental setup on granitic numerical rock samples consisting of quartz, feldspar and biotite minerals, the sample is first heated slowly to a target temperature below the Curie point. Then, a uniaxial tension test is numerically performed on the cooled down sample. The simulations demonstrate the validity of the proposed approach as the experimental deterioration of the tensile strength of the rock is predicted with agreeable accuracy.
Fibril Growth Behavior of Amyloid β on Polymer-Based Planar Membranes: Implications for the Entanglement and Hydration of Polymers
Authors: Shimanouchi Toshinori , Iwamura Miki , Deguchi Shintaro , Kimura Yukitaka
Published: May 2021

The design of biosensors and artificial organs using biocompatible materials with a low affinity for amyloid β peptide (Aβ) would contribute to the inhibition of fibril growth causing Alzheimer’s disease. We systematically studied the amyloidogenicity of Aβ on various planar membranes. The planar membranes were prepared using biocompatible polymers, viz., poly(methyl methacrylate) (PMMA), polysulfone (PSf), poly(L-lactic acid) (PLLA), and polyvinylpyrrolidone (PVP). Phospholipids from biomembranes, viz., 1,2-dioleoyl-phosphatidylcholine (DOPC), 1,2-dipalmitoyl-phosphatidylcholine (DPPC), and polyethylene glycol-graft-phosphatidyl ethanolamine (PEG-PE) were used as controls. Phospholipid- and polymer-based membranes were prepared to determine the kinetics of Aβ fibril formation. Rates of Aβ nucleation on the PSf- and DPPC-based membranes were significantly higher than those on the other membranes. Aβ accumulation, calculated by the change in frequency of a quartz crystal microbalance (QCM), followed the order: PSf > PLLA > DOPC > PMMA, PVP, DPPC, and PEG-PE. Nucleation rates exhibited a positive correlation with the corresponding accumulation (except for the DPPC-based membrane) and a negative correlation with the molecular weight of the polymers. Strong hydration along the polymer backbone and polymer–Aβ entanglement might contribute to the accumulation of Aβ and subsequent fibrillation.
Discrete Nonlinear Schrödinger Systems for Periodic Media with Nonlocal Nonlinearity: The Case of Nematic Liquid Crystals
Authors: Panayotaros Panayotis
Published: May 2021

We study properties of an infinite system of discrete nonlinear Schrödinger equations that is equivalent to a coupled Schrödinger-elliptic differential equation with periodic coefficients. The differential equation was derived as a model for laser beam propagation in optical waveguide arrays in a nematic liquid crystal substrate and can be relevant to related systems with nonlocal nonlinearities. The infinite system is obtained by expanding the relevant physical quantities in a Wannier function basis associated to a periodic Schrödinger operator appearing in the problem. We show that the model can describe stable beams, and we estimate the optical power at different length scales. The main result of the paper is the Hamiltonian structure of the infinite system, assuming that the Wannier functions are real. We also give an explicit construction of real Wannier functions, and examine translation invariance properties of the linear part of the system in the Wannier basis.
Solution-Processed NiO as a Hole Injection Layer for Stable Quantum Dot Light-Emitting Diodes
Authors: Lee Sangwon , Kim Youngjin , Kim Jiwan
Published: May 2021

In this work, we fabricated quantum dot light-emitting diodes using solution-processed NiO as the hole injection layer to replace the commonly used poly(3,4-ethylenedioxythiophene): poly(styrene-sulfonate) (PEDOT:PSS) layer. We successfully prepared NiO films by spin coating the NiO precursor, then annealing them, and then treating them with UV-ozone under optimized conditions. The best device with the NiO film shows higher current efficiency (25.1 cd/A) than that with the PEDOT:PSS layer (22.3 cd/A). Moreover, the long-term stability of the devices with NiO which is annealed at 500 °C is improved substantially. These results suggest that the NiO layer can be a good alternative for developing stable devices.
Posture-Transformed Monkey Phantoms Developed from a Visible Monkey
Authors: Kim Chung Yoh , Lee Ae-Kyoung , Choi Hyung-Do , Park Jin Seo
Published: May 2021

A monkey phantom is of significant value for electromagnetic radiation (EMR) dosimetry simulations. Furthermore, phantoms in various postures are needed because living beings are exposed to EMR in various postures during their daily routine. In this study, we attempted to produce monkey phantoms based on three daily postures of a rhesus monkey. From our Visible Monkey project, we selected surface models with 177 monkey structures. In the surface models, 52 virtual joints were created to allow for changes from the anatomical position to quadrupedal and sitting positions using commercial software. The surface models of the three positions were converted into monkey voxel phantoms. These phantoms were arranged in three positions, and the number of voxels and mass of each structure were analyzed. The phantoms in anatomical, quadrupedal, and sitting positions have a total of 5,054,022, 5,174,453, and 4,803,886 voxels, respectively. The mass of 177 structures in three positions were also calculated based on the number of voxels. By comparing the monkey phantom with the phantom of a female human, we confirmed thicker skin, less fat, heavier muscle, and a lighter skeleton in monkeys than those in humans. Through posture-transformed monkey phantoms, more precise EMR simulations could be possible. The ultimate purpose of this study is to determine the effects of EMR on humans. For this purpose, we will create posture-transformed human phantoms in a following study using the techniques employed herein and the human phantoms from our previous study.
Quantitative Inspection of Complex-Shaped Parts Based on Ice-Coupled Ultrasonic Full Waveform Inversion Technology
Authors: Xu Wenjin , Yuan Maodan , Xuan Weiming , Ji Xuanrong , Chen Yan
Published: May 2021

Ultrasonic methods have been extensively developed in nondestructive testing for various materials and components. However, accurately extracting quantitative information about defects still remains challenging, especially for complex structures. Although the immersion technique is commonly used for complex-shaped parts, the large mismatch of acoustic impedance between water and metal prevents effective ultrasonic transmission and leads to a low signal-to-noise ratio(SNR). In this paper, a quantitative imaging method is proposed for complex-shaped parts based on an ice-coupled full waveform inversion (FWI) method. Numerical experiments were carried out to quantitatively inspect the various defects in a turbine blade. Firstly, the k-space pseudospectral method was applied to simulate ice-coupled ultrasonic testing for the turbine blade. The recorded full wavefields were then applied for a frequency-domain FWI based on the Limited-memory Broyden–Fletcher–Goldfarb–Shanno (L-BFGS) method. With a carefully selected iterative number and frequency, a successive-frequency FWI can well detect half wavelength defects. Extended studies on an open notch with different orientations and multiple adjacent defects proved its capability to detect different types of defects. Finally, an uncertainty analysis was conducted with inaccurate initial velocity models with a relative error of ±2%, demonstrating its robustness even with a certain inaccuracy. This study demonstrates that the proposed method has a high potential to inspect complex-shaped structures with an excellent resolution.
Anatomical Characteristics of the Masseter Muscle in Mandibular Prognathism
Authors: Yang Ji Ho , Shin Dong Sun , Yoo Jeong-Hun , Lim Hun Jun , Lee Jun , Kim Bong Chul
Published: May 2021

Mandibular prognathism causes functional and esthetic problems. Therefore, many studies have been conducted to understand its etiology. Following our previous study, which revealed that the major characteristic of the mandible with prognathism is the volume/length ratio of the mandibular body and condyle, we analyzed the volume and orientation of the masseter muscle, which inserts into the mandibular body, expecting that the difference in the size of the masseter muscle causes the difference in the mandibular size. This study compared the masseter muscle of the participants in the prognathic group to those in the normal group on the volume/length ratio and orientation. The masseter muscle ratios (volume/length); the angle between the superficial and deep head of the masseter muscle; and the three planes (the palatal, occlusal, and mandibular) were analyzed. A total of 30 participants constituted the normal group (male: 15, female: 15) and 30 patients, the prognathic group (male: 15, female: 15). The results showed that the volume/length ratio of the masseter of the normal group was greater than that of the prognathic group (p < 0.05). In addition, the orientation of both the superficial and deep head of the masseter of the participants in the normal group was more vertical with respect to the mandibular plane than that of the prognathic group (p < 0.05). We concluded that the mechanical disadvantage of the masseter muscle of the prognathic group is attributed to mandibular prognathism.
Occupational Radiation Dose, Especially for Eye Lens: Hp(3), in Medical Staff Members Involved in Computed Tomography Examinations
Authors: Osanai Minoru , Sato Hidenori , Sato Kana , Kudo Kohsei , Hosoda Masahiro , Hosokawa Shota , Kitajima Maiko , Tsushima Megumi , Fujita Akira , Hosokawa Yoichiro , Saito Yoko
Published: May 2021

Radiation dose management of medical staff has become increasingly important. Particularly, based on the statement by the International Commission on Radiological Protection (ICRP) in 2011, a new lower equivalent dose limit for the eye lens is being established in each country. Although many reports have discussed the occupational radiation dose in interventional radiology (IR), few studies have examined the dose during computed tomography (CT) examinations. This study investigated the radiation dose exposure to medical staff present in the CT room during irradiation, with particular focus on the exposure to eye lens. The radiation dose exposure to those who assist patients during head, chest and upper abdomen CT examination was measured in a phantom study. The radiation dose exposure with scattered radiation was never negligible (i.e., high); Hp(3) was the highest in head CT examination, at 0.44 mSv per examination. Furthermore, the shielding effect of radiation protection glasses was large, and radiation protection glasses are useful tools for the medical staff who are involved in CT examinations. The justification and optimisation should be carefully considered in assistant actions.
Bioactive Compounds from Herbal Medicine Targeting Multiple Myeloma
Authors: Cotoraci Coralia , Ciceu Alina , Sasu Alciona , Miutescu Eftimie , Hermenean Anca
Published: May 2021

Multiple myeloma (MM) is one of the most widespread hematological cancers. It is characterized by a clonal proliferation of malignant plasma cells in the bone marrow and by the overproduction of monoclonal proteins. In recent years, the survival rate of patients with multiple myeloma has increased significantly due to the use of transplanted stem cells and of the new therapeutic agents that have significantly increased the survival rate, but it still cannot be completely cured and therefore the development of new therapeutic products is needed. Moreover, many patients have various side effects and face the development of drug resistance to current therapies. The purpose of this review is to highlight the bioactive active compounds (flavonoids) and herbal extracts which target dysregulated signaling pathway in MM, assessed by in vitro and in vivo experiments or clinical studies, in order to explore their healing potential targeting multiple myeloma. Mechanistically, they demonstrated the ability to promote cell cycle blockage and apoptosis or autophagy in cancer cells, as well as inhibition of proliferation/migration/tumor progression, inhibition of angiogenesis in the tumor vascular network. Current research provides valuable new information about the ability of flavonoids to enhance the apoptotic effects of antineoplastic drugs, thus providing viable therapeutic options based on combining conventional and non-conventional therapies in MM therapeutic protocols.
Identifying an lncRNA-Related ceRNA Network to Reveal Novel Targets for a Cutaneous Squamous Cell Carcinoma
Authors: Xu Yaqin , Dong Yingying , Deng Yunhua , Qi Qianrong , Wu Mi , Liang Hongmei , She Qiuyun , Guo Qing
Published: May 2021

A cutaneous squamous cell carcinoma (cSCC) derived from keratinocytes is the second most common cause of non-melanoma skin cancer. The accumulation of the mutational burden of genes and cellular DNA damage caused by the risk factors (e.g., exposure to ultraviolet radiation) contribute to the aberrant proliferation of keratinocytes and the formation of a cSCC. A cSCC encompasses a spectrum of diseases that range from recursor actinic keratosis (AK) and squamous cell carcinoma (SCC) in situ (SCCIS) to invasive cSCCs and further metastatic SCCs. Emerging evidence has revealed that lncRNAs are involved in the biological process of a cSCC. According to the ceRNA regulatory theory, lncRNAs act as natural miRNA sponges and interact with miRNA response elements, thereby regulating the mRNA expression of their down-stream targets. This study was designed to search for the potential lncRNAs that may become potential therapeutic targets or biomarkers of a cSCC. Considering the spirit of the study to be adequately justified, we collected microarray-based datasets of 19 cSCC tissues and 12 normal skin samples from the GEO database (GSE42677 and GSE45164). After screening the differentially expressed genes via a limma package, we identified 24 differentially expressed lncRNAs (DElncRNAs) and 3221 differentially expressed mRNAs (DEmRNAs). The miRcode, miRTarBase, miRDB and TargetScan databases were used to predict miRNAs that could interact with DElncRNAs and DEmRNAs. A total of 137 miRNA-lncRNA and 221 miRNA-mRNA pairs were retained in the ceRNA network, consisting of 31 miRNAs, 11 DElncRNAs and 155 DEmRNAs. For the functional analysis, the top enriched biological process was enhancer sequence-specific DNA binding in Gene Ontology (GO) terms. The FoxO signaling pathway, autophagy and cellular senescence were the top enrichment terms based on a Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. The combination of a STRING tool and Cytoscape software (plug-in MCODE) identified five core mRNAs and built a core mRNA-associated ceRNA network. The expression for five identified core mRNAs and their related nine lncRNAs was validated using the external dataset GSE7553. Finally, one lncRNA HLA-F-AS1 and three mRNAs named AGO4, E2F1 and CCND1 were validated with the same expression patterns. We speculate that lncRNA HLA-F-AS1 may sponge miR-17-5p or miR-20b-5p to regulate the expression of CCND1 and E2F1 in the cSCC. The present study may provide potential diagnostic and therapeutic targets for cSCC patients.
An “Omic” Overview of Fragile X Syndrome
Authors: Dionne Olivier , Corbin François
Published: May 2021

Fragile X syndrome (FXS) is a neurodevelopmental disorder associated with a wide range of cognitive, behavioral and medical problems. It arises from the silencing of the fragile X mental retardation 1 (FMR1) gene and, consequently, in the absence of its encoded protein, FMRP (fragile X mental retardation protein). FMRP is a ubiquitously expressed and multifunctional RNA-binding protein, primarily considered as a translational regulator. Pre-clinical studies of the past two decades have therefore focused on this function to relate FMRP’s absence to the molecular mechanisms underlying FXS physiopathology. Based on these data, successful pharmacological strategies were developed to rescue fragile X phenotype in animal models. Unfortunately, these results did not translate into humans as clinical trials using same therapeutic approaches did not reach the expected outcomes. These failures highlight the need to put into perspective the different functions of FMRP in order to get a more comprehensive understanding of FXS pathophysiology. This work presents a review of FMRP’s involvement on noteworthy molecular mechanisms that may ultimately contribute to various biochemical alterations composing the fragile X phenotype.
PPARgamma: A Potential Intrinsic and Extrinsic Molecular Target for Breast Cancer Therapy
Authors: Augimeri Giuseppina , Bonofiglio Daniela
Published: May 2021

Over the last decades, the breast tumor microenvironment (TME) has been increasingly recognized as a key player in tumor development and progression and as a promising prognostic and therapeutic target for breast cancer patients. The breast TME, representing a complex network of cellular signaling—deriving from different stromal cell types as well as extracellular matrix components, extracellular vesicles, and soluble growth factors—establishes a crosstalk with cancer cells sustaining tumor progression. A significant emphasis derives from the tumor surrounding inflammation responsible for the failure of the immune system to effectively restrain breast cancer growth. Thus, effective therapeutic strategies require a deeper understanding of the interplay between tumor and stroma, aimed at targeting both the intrinsic neoplastic cells and the extrinsic surrounding stroma. In this scenario, peroxisome proliferator-activated receptor (PPAR) γ, primarily known as a metabolic regulator, emerged as a potential target for breast cancer treatment since it functions in breast cancer cells and several components of the breast TME. In particular, the activation of PPARγ by natural and synthetic ligands inhibits breast cancer cell growth, motility, and invasiveness. Moreover, activated PPARγ may educate altered stromal cells, counteracting the pro-inflammatory milieu that drive breast cancer progression. Interestingly, using Kaplan–Meier survival curves, PPARγ also emerges as a prognostically favorable factor in breast cancer patients. In this perspective, we briefly discuss the mechanisms by which PPARγ is implicated in tumor biology as well as in the complex regulatory networks within the breast TME. This may help to profile approaches that provide a simultaneous inhibition of epithelial cells and TME components, offering a more efficient way to treat breast cancer.
N-Alkylation of Anthracycline Antibiotics by Natural Sesquiterpene Lactones as a Way to Obtain Antitumor Agents with Reduced Side Effects
Authors: Neganova Margarita , Semakov Alexey , Aleksandrova Yulia , Yandulova Ekaterina , Pukhov Sergey , Anikina Lada , Klochkov Sergey
Published: May 2021

Anthracycline antitumor antibiotics are one of the promising classes of chemotherapeutic agents for cancer treatment. The main deterrent to their use is high toxicity to a healthy environment, including cumulative cardiotoxicity. In our work, bipharmacophore molecules containing in their structure a fragment of the known anthracycline antibiotics daunorubicin and doxorubicin and natural sesquiterpene lactones were obtained for the first time. When studying the biological activity of the synthesized compounds, it was found that with equal and, in some cases, higher cytotoxicity and glycolysis inhibition by anthracycline antibiotics conjugates with sesquiterpene lactones in comparison with doxo- and daunorubicin, a reduced damaging effect on the functioning of rat heart mitochondria was observed. The results obtained allow us to confirm the assumption that the chemical modification of the anthracycline antibiotics molecules doxo- and daunorubicin by natural sesquiterpene lactones can be a promising strategy for creating potential antitumor chemotherapeutic drugs with a pronounced cytotoxic effect on tumor cells and a reduced damaging effect on healthy cells of the human organism.
Combination of Mesenchymal Stem Cell-Delivered Oncolytic Virus with Prodrug Activation Increases Efficacy and Safety of Colorectal Cancer Therapy
Authors: Ho Chun-Te , Wu Mei-Hsuan , Chen Ming-Jen , Lin Shih-Pei , Yen Yu-Ting , Hung Shih-Chieh
Published: May 2021

Although oncolytic viruses are currently being evaluated for cancer treatment in clinical trials, systemic administration is hindered by many factors that prevent them from reaching the tumor cells. When administered systemically, mesenchymal stem cells (MSCs) target tumors, and therefore constitute good cell carriers for oncolytic viruses. MSCs were primed with trichostatin A under hypoxia, which upregulated the expression of CXCR4, a chemokine receptor involved in tumor tropism, and coxsackievirus and adenovirus receptor that plays an important role in adenoviral infection. After priming, MSCs were loaded with conditionally replicative adenovirus that exhibits limited proliferation in cells with a functional p53 pathway and encodes Escherichia coli nitroreductase (NTR) enzymes (CRAdNTR) for targeting tumor cells. Primed MSCs increased tumor tropism and susceptibility to adenoviral infection, and successfully protected CRAdNTR from neutralization by anti-adenovirus antibodies both in vitro and in vivo, and specifically targeted p53-deficient colorectal tumors when infused intravenously. Analyses of deproteinized tissues by UPLC-MS/QTOF revealed that these MSCs converted the co-administered prodrug CB1954 into cytotoxic metabolites, such as 4-hydroxylamine and 2-amine, inducing oncolysis and tumor growth inhibition without being toxic for the host vital organs. This study shows that the combination of oncolytic viruses delivered by MSCs with the activation of prodrugs is a new cancer treatment strategy that provides a new approach for the development of oncolytic viral therapy for various cancers.
Distress, Depression, Anxiety, and Concerns and Behaviors Related to COVID-19 during the First Two Months of the Pandemic: A Longitudinal Study in Adult MEXICANS
Authors: Toledo-Fernández Aldebarán , Betancourt-Ocampo Diana , González-González Alejandro
Published: May 2021

We examined longitudinal differences in the severity of distress, depression, anxiety, and concerns and behaviors related to COVID-19 during the first two months of this pandemic, correlations between these variables, and interactions of distress with significant sociodemographics across waves. A longitudinal online survey was conducted in the State of Mexico, from 8 April to 27 May, 2020, in a sample of men and women between 18 and 60 years old, using: Impact of Event Scale-6, Patient Health Questionnaire-9, General Anxiety Disoder-7, and a questionnaire of concerns and behaviors related to COVID-19. Six hundred seventy participants were analyzed. Only a mild difference in distress was observed between the two waves and mild correlations of this variable with contagion in oneself and in a relative. Having a high-risk medical condition proved a considerable effect on distress within both waves. Perception of usefulness of preventive measures, concerns of contagion in a relative, and financial and security situations scored high within our questionnaire but did not change in the follow-up. We hypothesize that habituation to distressful events in the Mexican population (emergent resilience) might explain the absence of meaningful differences. Our research adds to the monitoring of mental health in Mexicans during the COVID-19 pandemic; its findings can serve to perform comparisons in other studies and for further meta-analyses.
Evaluation of Pulsed Electric Field Polyphenol Extraction from Vitis vinifera, Sideritis scardica and Crocus sativus
Authors: Lakka Achillia , Bozinou Eleni , Makris Dimitris P. , Lalas Stavros I.
Published: May 2021

This study exploited the application of pulsed electric field (PEF) on the recovery of polyphenols from aerial parts of Sideritis scardica, tepals of Crocus sativus, and fruits of Vitis vinifera. Short pulses of 10 μs in a period of 1 ms were applied to the plant material, while different electric field intensities, 1.2 to 2.0 kV/cm were tested to optimize the procedure. The content in total polyphenols and the polyphenolic profile of the plant extracts were evaluated. Along with PEF samples, control samples were prepared for comparison. PEF treatment enhanced the recovery in total polyphenols for all the three plants examined. A significant increase was noticed in each plant tested and PEF condition applied, though lower electric field intensities up to 1.4 kV/cm proved to be more effective. Under the optimum electric field intensities, 1.4 kV/cm for V. vinifera and 1.2 kV/cm for S. scardica and C. sativus, increases of 49.15%, 35.25%, and 44.36% in total polyphenol content, respectively, were achieved. Additionally, an 85% increase of quercetin 3-rutinoside for V. vinifera, a 56% of apigenin 7-O-glucoside for S. scardica, and a 64% increase for kaempferol 3-O-glucoside for C. sativus were obtained.
Climatic Analysis of Wind Patterns to Enhance Sailors’ Performance during Races
Authors: Masino Pietro , Bellasio Roberto , Bianconi Roberto , Besana Angelo , Pezzoli Alessandro
Published: May 2021

The impact of environmental and meteorological conditions when dealing with sport performance has been demonstrated by several studies carried out in recent years. Among the meteorological variables with the greatest effect are temperature, humidity, precipitation, and wind direction and speed. This research focused on analyzing and forecasting the wind patterns occurring in Enoshima Bay (Japan). In particular, the objective of this study was to provide support and guidance to sailors in the preparation of the race strategy, thanks to an in-depth knowledge of these meteorological variables. To do this, an innovative method was used. First, through the combined use of Weather Research and Forecasting (WRF) and CALMET models, a simulation was performed, in order to reconstruct an offshore database of a recent 10-year period (2009–2018) over the race area, inside the bay. Subsequently, the verification of hind-cast was performed: the wind data measured at sea were compared with the data extracted from the CALMET database to verify the validity of the model. The verification was performed through three statistical indexes: BIAS, MAE, and PCC. The analysis showed mixed results, depending on the examined pattern, but made it possible to identify the days that best simulated the reality. Then, the wind data from the selected days were summarized and collected in plots, tables, and maps to design a decision support service (DSS), in order to provide athletes with the necessary information in a simple and effective way. In conclusion, we state that the application of this method extends beyond the sports field. Indeed, the study of wind patterns may be necessary in the design of actions to contrast and adapt to climate change, particularly in coastal areas.
Hand Strength Deficit in Patients with Neurogenic Thoracic Outlet Syndrome
Authors: Fouasson-Chailloux Alban , Daley Pauline , Menu Pierre , Louguet Bastien , Gadbled Guillaume , Bouju Yves , Abraham Pierre , Dauty Marc
Published: May 2021

Neurogenic thoracic outlet syndrome (NTOS) is a chronic painful and disabling condition. Patients complain about upper-limb paresthesia or weakness. Weakness has been considered one of the diagnostic criteria of NTOS, but objective comparisons to healthy controls are lacking. We compared the grip and the key pinch strengths between NTOS patients and healthy controls. Grip strength was evaluated with a hydraulic hand dynamometer and the key pinch with a pinch gauge. All the patients with NTOS completed a QuickDASH. We included prospectively 85 patients with NTOS, 73% female and 27% male. The mean age was 40.4 ± 9.6. They were compared to 85 healthy subjects, 77.6% female and 22.4% male. Concerning the grip, symptomatic hands of NTOS patients had significantly 30% less strength compared to control hands (p ≤ 0.001), and 19% less strength compared to asymptomatic hands (p = 0.03). Concerning the key pinch, symptomatic hands of patients with NTOS had significantly 19.5% less strength compared to control hands (p ≤ 0.001). Grip and key pinch strengths had a significant correlation with the QuickDASH (r = −0.515 and r = −0.403, respectively; p ≤ 0.001). Patients with NTOS presented an objective hand strength deficit compared to healthy controls. This deficit was significantly correlated to the upper-limb disability. These findings confirm the interest of hand strength evaluation in the diagnostic process of patients with NTOS.
FTRLIM: Distributed Instance Matching Framework for Large-Scale Knowledge Graph Fusion
Authors: Zhu Hongming , Wang Xiaowen , Jiang Yizhi , Fan Hongfei , Du Bowen , Liu Qin
Published: May 2021

Instance matching is a key task in knowledge graph fusion, and it is critical to improving the efficiency of instance matching, given the increasing scale of knowledge graphs. Blocking algorithms selecting candidate instance pairs for comparison is one of the effective methods to achieve the goal. In this paper, we propose a novel blocking algorithm named MultiObJ, which constructs indexes for instances based on the Ordered Joint of Multiple Objects’ features to limit the number of candidate instance pairs. Based on MultiObJ, we further propose a distributed framework named Follow-the-Regular-Leader Instance Matching (FTRLIM), which matches instances between large-scale knowledge graphs with approximately linear time complexity. FTRLIM has participated in OAEI 2019 and achieved the best matching quality with significantly efficiency. In this research, we construct three data collections based on a real-world large-scale knowledge graph. Experiment results on the constructed data collections and two real-world datasets indicate that MultiObJ and FTRLIM outperform other state-of-the-art methods.
Learner-Centred Learning Tasks in Higher Education: A Study on Perception among Students
Authors: Li Junmin
Published: May 2021

Universities face the challenge of constantly improving the quality of higher education and changing the learning behaviour of students, from passive reactive learning to active self-regulated learning. Learner-centred, constructively designed learning tasks offer a great opportunity here. This paper investigates to what extent the learning process is challenged by these learning tasks, and how these tasks are perceived by the students, using a before and after survey of students studying at bachelor level in business courses at a German university. The paper starts with a short description of constructivism in the context of task design and the main characteristics of learner-centred, constructivist-orientated learning tasks: openness to problems, situation orientation, openness to solution paths, and degree of difficulty. Then the research method used is outlined before the findings are presented. The before and after survey shows that despite an increased complexity and workload, the motivation to deal with topics on the subject remained stable.
Designing an Accounting Course Module on Cost Allocation: Pedagogical and Didactical Considerations from a Norwegian Perspective
Authors: Timoshenko Konstantin , Hansen Odd Birger , Madsen Dag Øivind , Stenheim Tonny
Published: May 2021

This paper aims to elucidate some didactical and pedagogical issues related to the design of a course module on cost allocation, a pivotal topic in management accounting education at the undergraduate level around the globe. The module in question is specifically tailored to third-year undergraduates in business pursuing a major in accounting-related topics. As a theoretical backdrop, the paper draws on the didactical relationship model developed by Norwegian education researchers Hiim and Hippe. While it has proved to be of considerable value in planning education and teaching in Norwegian primary and upper secondary schools, this model, to the best of the authors’ knowledge, has not previously been applied in the context of accounting education at the university level. Without seeking to wholly generalize our thoughts and views to all higher educational institutions, we refer, in this paper, primarily to our own personal experiences of teaching management accounting gained at the three Norwegian universities, namely, Nord University, University of South-Eastern Norway, and The Arctic University of Norway. It is argued in this paper that the didactical relationship model may be of great help to accounting educators by providing an illustrative account of key conditioning factors (didactic elements) to consider while planning the learning process. Additionally, the paper strives to delve deeper into the use of technology in light of the current COVID-19 situation that we are all locked in.
Fast Fallback Watermark Detection Using Perceptual Hashes
Authors: Mareen Hannes , Van Kets Niels , Lambert Peter , Van Wallendael Glenn
Published: May 2021

Forensic watermarking is often used to enable the tracing of digital pirates that leak copyright-protected videos. However, existing watermarking methods have a limited robustness and may be vulnerable to targeted attacks. Our previous work proposed a fallback detection method that uses secondary watermarks rather than the primary watermarks embedded by existing methods. However, the previously proposed fallback method is slow and requires access to all watermarked videos. This paper proposes to make the fallback watermark detection method faster using perceptual hashes instead of uncompressed secondary watermark signals. These perceptual hashes can be calculated prior to detection, such that the actual detection process is sped up with a factor of approximately 26,000 to 92,000. In this way, the proposed method tackles the main criticism about practical usability of the slow fallback method. The fast detection comes at the cost of a modest decrease in robustness, although the fast fallback detection method can still outperform the existing primary watermark method. In conclusion, the proposed method enables fast and more robust detection of watermarks that were embedded by existing watermarking methods.
A Quad-Band RF Circuit for Enhancement of Energy Harvesting
Authors: Selim Kyrillos , Wu Shaochuan , Saleeb Demyana , Ghoneim Sherif
Published: May 2021

Radio frequency energy harvesting is one of the new renewable sources that faces some technical challenges, which limit its performance. This study presents two scenarios to enhance the harvested power. The first scenario introduces a quad-band voltage multiplier circuit with a single receiving antenna and four band-pass filters of elliptic type. In this scenario, four frequencies of the Global System for Mobile communications, Universal Mobile Telecommunications System, and Wireless Fidelity frequency bands have been considered for the study. The second scenario proposes a quad-band voltage multiplier circuit with four receiving antennas at the same frequency bands as the first scenario. High conversion efficiencies were achieved for the two scenarios. The proposed quad-band system developed a harvested power level, sufficient for powering up low power micro-devices with no need for an external power supply.
Fixed-Point Arithmetic Unit with a Scaling Mechanism for FPGA-Based Embedded Systems
Authors: Przybył Andrzej
Published: May 2021

The work describes the new architecture of a fixed-point arithmetic unit. It is based on the use of integer arithmetic operations for which the information about the scale of the processed numbers is contained in the binary code of the arithmetic instruction being executed. Therefore, this approach is different from the typical way of implementing fixed-point operations on standard processors. The presented solution is also significantly different from the one used in floating-point arithmetic, as the decision to determine the appropriate scale is made at the stage of compiling the code and not during its execution. As a result, the real-time processing of real numbers is simplified and, therefore, faster. The described method provides a better ratio of the processing efficiency to the complexity of the digital system than other methods. In particular, the advantage of using the described method in FPGA-based embedded control systems should be indicated. Experimental tests on an industrial servo-drive confirm the correctness of the described solution.
Design Considerations for Adding Series Inductors to Reduce Electromagnetic Field Interference in an Over-Coupled WPT System
Authors: Shin Yujun , Park Jaehyoung , Kim Haerim , Woo Seongho , Park Bumjin , Huh Sungryul , Lee Changmin , Ahn Seungyoung
Published: May 2021

This paper analyzes how over-coupled coils affect odd harmonic current and electromagnetic interference (EMI) in a wireless power transfer (WPT) system, and proposes design considerations for series inductors to solve the EMI problem. When the air gap of the coils of the WPT system decreases below a certain level and the coils are over-coupled, the odd harmonic component of the input impedance of the system decreases and odd harmonic currents increase. The increase in the odd harmonic components current quickly aggravates the EMI issues. To solve the EMI problem of the over-coupled WPT system, additional series inductors were applied to the system, and considerations for designing the series inductors were analyzed. When designing additional series inductors, power transfer efficiency, maximum power transfer, input impedance and odd harmonic components current must be considered. Using simulations and experiments, it was confirmed that the WPT system designed with analyzed considerations maintained relatively high efficiency and reduced EMI issues.
Coping with Energy Poverty: Measurements, Drivers, Impacts, and Solutions
Authors: Halkos George E. , Gkampoura Eleni-Christina
Published: May 2021

Energy is required for socioeconomic development, and the world’s energy needs have significantly increased in the last decades. The lack of energy can have severe impacts on a person’s well-being; therefore, energy access should be ensured for everyone in the world. Energy poverty usually refers to a situation where a household cannot be kept adequately warm, but it is a complex issue with many more aspects. This paper aims to present a comprehensive review of the energy poverty problem, particularly presenting various definitions given in the literature that capture the multi-dimensional nature of the problem and analyzing the different ways of measuring energy poverty (expenditure approach and consensual approach). In addition, the impacts of the problem are identified, including health, socioeconomic, and environmental impacts, as well as the drivers that can worsen energy poverty conditions, such as several household characteristics and various socioeconomic and environmental factors. The situation occurring currently in the world is also presented, including studies that focus on different world regions, and the different solutions that can help address the problem are discussed, including changes to the living environments and the use of new technologies.
Saturation Carrying Capacity for Group A Particles in a Circulating Fluidized Bed
Authors: Breault Ronald W. , Weber Justin
Published: May 2021

Empirical models continue to play a significant role in the design process of multiphase chemical reactors, particularly riser reactors in circulating fluidized bed (CFB) processes. It is imperative that accurate, industrial relevant correlations are developed to aid these design efforts. Using poor correlations could result in startup issues and significant redesign work. In this work, a new correlation is proposed to predict the saturation carrying capacity of Geldart Group A particles. This new correlation improves upon the currently available correlations for these materials and covers a broad range of Geldart Group A particles (particle diameters from 52 to 70 µm, and Archimedes numbers ranging from 5 to 20), superficial gas velocities (1 to 4 m/s), and riser diameters (0.066 to 0.3048 m). The new correlation has an Absolute Average Percent Deviation of only 17.6%, making it the most accurate correlation for Geldart Group A particles in the current literature.
Naturally-Coupled Dark Sectors
Authors: Demir Durmuş
Published: May 2021

The dark sector, composed of fields that are neutral under the standard model (SM) gauge group, can couple to the SM through the Higgs, hypercharge and neutrino portals, and pull the SM towards its scale by loop corrections. This instability, which is not possible to prevent in the known SM completions, such as supersymmetry, due to the sizable couplings to the SM, calls for alternative mechanisms that can neutralize sensitivities of the SM to the dark sector scale and to the ultraviolet cutoff above it. Here we review such a mechanism in which incorporation of gravity into the SM predicts the existence of a dark sector and allows it to be naturally coupled to the SM. We discuss and illustrate salient processes that can probe the naturally coupled dark sectors.
Root Reinforcement in Slope Stability Models: A Review
Authors: Masi Elena Benedetta , Segoni Samuele , Tofani Veronica
Published: May 2021

The influence of vegetation on mechanical and hydrological soil behavior represents a significant factor to be considered in shallow landslides modelling. Among the multiple effects exerted by vegetation, root reinforcement is widely recognized as one of the most relevant for slope stability. Lately, the literature has been greatly enriched by novel research on this phenomenon. To investigate which aspects have been most treated, which results have been obtained and which aspects require further attention, we reviewed papers published during the period of 2015–2020 dealing with root reinforcement. This paper—after introducing main effects of vegetation on slope stability, recalling studies of reference—provides a synthesis of the main contributions to the subtopics: (i) approaches for estimating root reinforcement distribution at a regional scale; (ii) new slope stability models, including root reinforcement and (iii) the influence of particular plant species, forest management, forest structure, wildfires and soil moisture gradient on root reinforcement. Including root reinforcement in slope stability analysis has resulted a topic receiving growing attention, particularly in Europe; in addition, research interests are also emerging in Asia. Despite recent advances, including root reinforcement into regional models still represents a research challenge, because of its high spatial and temporal variability: only a few applications are reported about areas of hundreds of square kilometers. The most promising and necessary future research directions include the study of soil moisture gradient and wildfire controls on the root strength, as these aspects have not been fully integrated into slope stability modelling.