bluuebunny/crossref_metadata_2025 huggingface dataset:
Resveratrol attenuates mitochondrial dysfunction in the liver of intrauterine growth retarded suckling piglets by improving mitochondrial biogenesis and redox status
Authors: Zhang Hao , Li Yue , Su Weipeng , Ying Zhixiong , Zhou Le , Zhang Lili , Wang Tian
Published: December 2016

Scope

Emerging evidence has identified mitochondrial biogenesis and oxidative phosphorylation as potential targets for the prevention and treatment of metabolic syndrome. This study investigated the effect of resveratrol (RSV) on hepatic mitochondrial function in intrauterine growth‐retarded (IUGR) suckling piglets.

Methods and results

Seven normal birth weight (NBW) and fourteen IUGR neonatal male piglets were selected. Piglets were fed control diets supplemented with 0 (NBW‐CON), 0 (IUGR‐CON), and 1.0 (IUGR‐RSV) g RSV per kg of milk dry matter from 7 to 21 days of age (n = 7), respectively. Mitochondrial function, swelling, and redox status in the liver were assessed. Compared with NBW, IUGR impaired hepatic mitochondrial biogenesis and energy homeostasis of the control piglets. IUGR control piglets showed overproduction of superoxide radicals, increased concentration of malondialdehyde, and marked swelling in the mitochondria. RSV improved mitochondrial DNA content, ATP production, and fatty acid oxidation in the liver of IUGR piglets, along with an increased activity of sirtuin 1. RSV inhibited mitochondrial superoxide anion accumulation, increased complex III and manganese superoxide dismutase activities, and ameliorated mitochondrial swelling and lipid peroxidation in the IUGR piglets.

Conclusion

RSV may have beneficial effects in improving hepatic mitochondrial function and redox status in the IUGR piglets.
Interrelationships among mediators of cellular zinc homeostasis in healthy and type 2 diabetes mellitus populations
Authors: Chu Anna , Foster Meika , Hancock Dale , Petocz Peter , Samman Samir
Published: December 2016

Scope

The involvement of zinc in multiple physiological systems requires tight control of cellular zinc concentration. This study aims to explore the relationships among selected mediators of cellular zinc homeostasis in an apparently healthy (AH) population and a cohort with type 2 diabetes mellitus (T2DM).

Methods and results

Baseline data of three trials forming two cohorts, AH (n = 70) and T2DM (n = 42), were used for multivariate analyses to identify groupings within ten zinc transporter and metallothionein (MT) gene expressions, stratified by health status. Multiple regression models were used to explore relationships among zinc transporter/MT groupings and plasma zinc. Gene expression of zinc transporters and MTs, with the exception of ZnT6, were significantly lower in the T2DM cohort (p < 0.01). Cluster analysis showed that the groupings of zinc transporters and MTs were largely similar between the two cohorts, with the exception for ZnT1 and ZIP7. Zinc transporters and MTs were significant determinants of plasma zinc (r2 = 0.48, p = 0.001) in the AH cohort, but not in the T2DM cohort.

Conclusion

The current study suggests altered cellular zinc homeostasis in T2DM and supports the use of multiple zinc transporters and MTs groupings to further understand zinc homeostasis in health and T2DM.
Effect of methoxyl groups on the NMR spectra: configuration and conformation of natural and synthetic indanic and tetralinic structures
Authors: Lantaño Beatriz , Aguirre José M. , Drago Eleonora V. , de la Faba Diego J. , Pomilio Nicolás , Mufato Jorge D.
Published: December 2016

Here, we studied the influence of the methoxyl groups attached at C‐7 and C‐2′ of natural and synthetic 1‐arylindanes on the chemical shift of the signal of bibenzylic hydrogen and carbon atoms andJ1,2coupling constants. This influence was also analysed in natural 1‐aryltetralins and related compounds that possess methoxyl and/or hydroxyl groups bound at C‐8 and C‐2′. The methoxyl groups attached at C‐7 in indanes or at C‐8 in tetralins produce a deshielding signal at H‐1 and shield at C‐1 and a strong decrease in the value ofJ1,2due to thepseudoequatoriallocation adopted by the aryl group bound at C‐1, avoiding an ‘A1,3strain’. Furthermore, compounds with hydroxyl or methoxyl groups in C‐2′, in the absence of substituents of C‐7 or C‐8, present a strong deshielding signal at H‐1, strong shield of the C‐1 signal and a decrease in the value ofJ1,2. This is attributed to the stereoelectronic effects of the methoxyl or hydroxyl groups, which we have called ‘Asarone effect’. NOESY experiments were conducted to confirm the configuration and conformation of some of the compounds included in this work. This study shows that both effects,A1,3strainandAsarone effect, must be taken into account when the structure of natural indanes and tetralins is analysed by using1H‐NMR and13C‐NMR spectra. Copyright © 2016 John Wiley & Sons, Ltd.
Network Formation by Free Radical Polymerization in Isothermal Continuous Flow Stirred Reactors
Authors: Nieves‐Remacha Maria Jose , Villa Carlos , Arriola Dan
Published: December 2016

The authors apply the method of moments to the study of network formation in continuous flow stirred reactors when chain transfer to polymer and coupling are present in the reaction scheme. This approach leads to analytical solutions for the various moments involved. The authors start by assuming that the rate of coupling is proportional to the length of dead chains, which allow them to review and extend previous work in this area. This is followed by similar derivations when a coupling agent is present and the rate of coupling is proportional to the number of coupling groups that such agent leaves in dead polymer molecules, demonstrating that higher values of second order moments can be reached at lower levels of unreacted coupling agent.

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In‐depth characterization of the tomato fruit pericarp proteome
Authors: Mata Clara I. , Fabre Bertrand , Hertog Maarten L. A. T. M. , Parsons Harriet T. , Deery Michael J. , Lilley Kathryn S. , Nicolaï Bart M.
Published: December 2016

Since the genome of Solanum lycopersicum L. was published in 2012, some studies have explored its proteome although with a limited depth. In this work, we present an extended characterization of the proteome of the tomato pericarp at its ripe red stage. Fractionation of tryptic peptides generated from pericarp proteins by off‐line high‐pH reverse‐phase phase chromatography in combination with LC‐MS/MS analysis on a Fisher Scientific Q Exactive and a Sciex Triple‐TOF 6600 resulted in the identification of 8588 proteins with a 1% FDR both at the peptide and protein levels. Proteins were mapped through GO and KEGG databases and a large number of the identified proteins were associated with cytoplasmic organelles and metabolic pathways categories. These results constitute one of the most extensive proteome datasets of tomato so far and provide an experimental confirmation of the existence of a high number of theoretically predicted proteins. All MS data are available in the ProteomeXchange repository with the dataset identifiers PXD004947 and PXD004932.
Structural and electrical properties of semipolar (11‐22) AlGaN grown on m‐plane (1‐100) sapphire substrates
Authors: Jo Masafumi , Oshima Issei , Matsumoto Takuma , Maeda Noritoshi , Kamata Norihiko , Hirayama Hideki
Published: December 2016

Semipolar III‐nitrides have attracted increasing attention because of the reduced piezoelectric field in the active layer. In particular, (11‐22) plane is promising due to the small polarization field along the growth axis and the epitaxial matching on m‐plane sapphire. The aim of this study was to assess the effect of growth conditions on the structural and electrical properties of Si‐doped (11‐22) AlGaN. Semipolar AlGaN/AlN layers were grown on m‐plane sapphire by metal‐organic chemical vapor deposition at different temperatures, V/III ratios, and tetraethylesilane flows. Surface morphology, crystalline quality, and electrical properties of the AlGaN layers were investigated with AFM, XRD, and by Hall measurements, respectively.
An ultrahigh‐performance chromatography/tandem mass spectrometry quantitative method for trace analysis of potential endocrine disrupting steroid hormones in estuarine sediments
Authors: Mulabagal Vanisree , Wilson Caleb , Hayworth Joel S.
Published: December 2016

Rationale

Estuaries are dynamic ecosystems, providing vital habitat for unique organisms of great ecological and commercial importance. The influx of natural and synthetic steroid hormones into estuaries poses risks to these organisms and to broader ecosystem health. However, detecting these trace level pollutants in estuarine water and sediment requires improved analytical techniques.

Methods

We describe an optimized ultrahigh‐performance chromatography/tandem mass spectrometry (UHPLC/MS/MS) method for simultaneous quantitation of four classes of steroid hormones (estrogens, glucocorticoids, androgens and progestins) in sediment samples collected from an Alabama estuary. Sediment samples were homogenized using Hydromatrix (HM) sorbent and extracted with methanol and water (70%, v/v). Centrifuged extracts were purified using an Agilent Bond Elut QuEChERS dispersive‐SPE kit to eliminate interfering substances that could negatively influence the ionization process. Chromatographic separation was achieved on a Poroshell 120 Phenyl‐Hexyl column using an Agilent 1290 Infinity II UHPLC pump. Quantitation was carried out using an Agilent triple quadrupole mass spectrometer equipped with a JetStream/ESI source in dual mode.

Results

Chromatographic separation and better peak resolution were accomplished on an Agilent Poroshell 120 Phenyl‐Hexyl column using a binary gradient method with a mobile phase consisting of 1 mM ammonium fluoride in water and a mixture of methanol/acetonitrile. A dynamic multiple reaction monitoring (MRM) method was developed by optimizing various MS parameters. The method was used to analyze target steroid hormones in estuarine sediments. A total of ten steroid hormones were detected at trace amounts in estuarine sediments.

Conclusions

The optimized analytical method described here involves reasonably simple sample preparation and simultaneous trace level quantitation of four classes (estrogens, glucocorticoids, androgens and progestins) of steroid hormones in a single experimental run. Copyright © 2016 John Wiley & Sons, Ltd.
Driving on Point Clouds: Motion Planning, Trajectory Optimization, and Terrain Assessment in Generic Nonplanar Environments
Authors: Krüsi Philipp , Furgale Paul , Bosse Michael , Siegwart Roland
Published: December 2016

We present a practical approach to global motion planning and terrain assessment for ground robots in generic three‐dimensional (3D) environments, including rough outdoor terrain, multilevel facilities, and more complex geometries. Our method computes optimized six‐dimensional trajectories compliant with curvature and continuity constraints directly on unordered point cloud maps, omitting any kind of explicit surface reconstruction, discretization, or topology extraction. We assess terrain geometry and traversability on demand during motion planning, by fitting robot‐sized planar patches to the map and analyzing the local distribution of map points. Our motion planning approach consists of sampling‐based initial trajectory generation, followed by precise local optimization according to a custom cost measure, using a novel, constraint‐aware trajectory optimization paradigm. We embed these methods in a complete autonomous navigation system based on localization and mapping by means of a 3D laser scanner and iterative closest point matching, suitable for both static and dynamic environments. The performance of the planning and terrain assessment algorithms is evaluated in offline experiments using recorded and simulated sensor data. Finally, we present the results of navigation experiments in three different environments—rough outdoor terrain, a two‐level parking garage, and a dynamic environment, demonstrating how the proposed methods enable autonomous navigation in complex 3D terrain.
Thermal Ripples in Model Molybdenum Disulfide Monolayers
Authors: Remsing Richard C. , Waghmare Umesh V. , Klein Michael L.
Published: December 2016

Molybdenum disulfide (MoS2) monolayers have the potential to revolutionize nanotechnology. To reach this potential, it will be necessary to understand the behavior of this two‐dimensional (2D) material on large length scales and under thermal conditions. Herein, we use molecular dynamics (MD) simulations to investigate the nature of the rippling induced by thermal fluctuations in monolayers of the 2H and 1T phases of MoS2. The 1T phase is found to be more rigid than the 2H phase. Both monolayer phases are predicted to follow long wavelength scaling behavior typical of systems with anharmonic coupling between vibrational modes as predicted by classic theories of membrane‐like systems.
Forward di-jet production in p+Pb collisions in the small-x improved TMD factorization framework
Authors: van Hameren A. , Kotko P. , Kutak K. , Marquet C. , Petreska E. , Sapeta S.
Published: December 2016

Abstract

We study the production of forward di-jets in proton-lead and proton-proton collisions at the Large Hadron Collider. Such configurations, with both jets produced in the forward direction, impose a dilute-dense asymmetry which allows to probe the gluon density of the lead or proton target at small longitudinal momentum fractions. Even though the jet momenta are always much bigger than the saturation scale of the target, Q
s, the transverse momentum imbalance of the di-jet system may be either also much larger than Q
s, or of the order Q
s, implying that the small-x QCD dynamics involved is either linear or non-linear, respectively. The small-x improved TMD factorization framework deals with both situations in the same formalism. In the latter case, which corresponds to nearly back-to-back jets, we find that saturation effects induce a significant suppression of the forward di-jet azimuthal correlations in proton-lead versus proton-proton collisions.
Assessing quality of life in Alzheimer's disease: Implications for clinical trials
Authors: Kahle‐Wrobleski Kristin , Ye Wenyu , Henley David , Hake Ann Marie , Siemers Eric , Chen Yun‐Fei , Liu‐Seifert Hong
Published: December 2016

Introduction

Characterization of the quality of life (QOL) in Alzheimer's disease (AD) scale within the context of a clinical trial may inform its applicability in future trials.

Methods

Using data from 1322 patients enrolled in two phase‐III studies (EXPEDITION 1 [NCT00905372] and 2 [NCT00904683]) of intravenous solanezumab in outpatients with mild AD dementia, correlations between patient‐ and caregiver‐assessed QOL and between QOL and clinical outcome measures were examined. Longitudinal effects of solanezumab over 80 weeks were explored, controlling for patient and caregiver baseline characteristics.

Results

Caregivers rated patients' QOL worse than did patients themselves. Patients' QOL was correlated, albeit modestly, with clinical/health measures. Patients' QOL changed minimally over 80 weeks, although a treatment effect of solanezumab on QOL was detected.

Discussion

Further investigations are needed to determine the optimal measures with which to quantify and qualify QOL of patients with mild AD.
Landscapes of Decadence
Authors: Murray Alex
Published: December 2016

The challenges posed by Decadence to Victorian moral conventions - particularly sexual - have been well documented, but this book makes the case for understanding Decadence as a response to the ways in which place was accorded moral value in the period. The book uses landscape as a key trope for exploring Decadent writing's approach to location and identity. Drawing on a wide range of fin-de-siècle literature organised around a series of locations from Naples to New York, Murray argues that Decadent writers developed a form of landscape and place-based writing using a series of stylistic features to challenge the increasing homogenisation of both place and literary culture. Decadence and the literature of the fin de siècle are re-framed as a politically-engaged form of landscape writing. This is an ambitious and richly researched study.
Introduction to Coalgebra
Authors: Jacobs Bart
Published: December 2016

The area of coalgebra has emerged within theoretical computer science with a unifying claim: to be the mathematics of computational dynamics. It combines ideas from the theory of dynamical systems and from the theory of state-based computation. Although still in its infancy, it is an active area of research that generates wide interest. Written by one of the founders of the field, this book acts as the first mature and accessible introduction to coalgebra. It provides clear mathematical explanations, with many examples and exercises involving deterministic and non-deterministic automata, transition systems, streams, Markov chains and weighted automata. The theory is expressed in the language of category theory, which provides the right abstraction to make the similarity and duality between algebra and coalgebra explicit, and which the reader is introduced to in a hands-on manner. The book will be useful to mathematicians and (theoretical) computer scientists and will also be of interest to mathematical physicists, biologists and economists.
Inertial flow of a dilute suspension over cavities in a microchannel
Authors: Haddadi Hamed , Di Carlo Dino
Published: December 2016

Microfluidic experiments and discrete particle simulations using the lattice-Boltzmann method are used to study interactions of finite size hard spheres and vortical flow inside confined cavities in a microchannel. The work focuses on entrapment of particles inside confined cavities and particle dynamics after entrapment. Numerical simulations and imaging of fluorescent tracers demonstrate that spiralling flow generates exchange of fluid mass between the vortical flow and the channel, contrary to the concept of a well-defined separatrix in unconfined cavities. An isolated finite size particle entrapped in the cavity migrates towards a stable orbit, i.e. a limit cycle trajectory. The topology of the limit cycle depends on cavity size, particle diameter and flow inertia, represented by Reynolds number. By studying various factors affecting the acceleration of a particle before entrapment, it is discussed that entrapment is a collective effect of flow morphology and particle dynamics. The effect of hydrodynamic interaction between particles inside the cavity, which results in deviation from the stable limit cycle orbit and depletion of cavities, will also be discussed. It is shown that a wall-confined microcavity entraps particles based on particle size, therefore it provides a platform for microfiltration.
Internal wave attractors: different scenarios of instability
Authors: Brouzet C. , Ermanyuk E. , Joubaud S. , Pillet G. , Dauxois T.
Published: December 2016

This paper presents an experimental study of different instability scenarios in a parallelogram-shaped internal wave attractor in a trapezoidal domain filled with a uniformly stratified fluid. Energy is injected into the system via the oscillatory motion of a vertical wall of the trapezoidal domain. Whole-field velocity measurements are performed with the conventional particle image velocimetry technique. In the linear regime, the total kinetic energy of the fluid system is used to quantify the strength of attractors as a function of coordinates in the parameter space defining their zone of existence, the so-called Arnold tongue. In the nonlinear regime, the choice of the operational point in the Arnold tongue is shown to have a significant impact on the scenario of the onset of triadic instability, most notably in terms of the influence of confinement on secondary waves. The onset of triadic resonance instability may occur as a spatially localized event similar to Scolan et al. (Phys. Rev. Lett., vol. 110, 2013, 234501) in the case of strong focusing or in form of growing normal modes as in McEwan (J. Fluid Mech., vol. 50, 1971, pp. 431–448) for the limiting case of rectangular domain. In the present paper, we describe also a new intermediate scenario for the case of weak focusing. We explore the long-term behaviour of cascades of triadic instabilities in wave attractors and show a persistent trend toward formation of standing-wave patterns corresponding to some discrete peaks of the frequency spectrum. At sufficiently high level of energy injection the system exhibits a ‘mixing box’ regime which has certain qualitatively universal properties regardless to the choice of the operating point in the Arnold tongue. In particular, for this regime, we observe a statistics of events with high horizontal vorticity, which serve as kinematic indicators of mixing.
Aeroacoustic source mechanisms of a wavy leading edge undergoing vortical disturbances
Authors: Turner Jacob M. , Kim Jae Wook
Published: December 2016

High-accuracy numerical simulations are performed to study aeroacoustic source mechanisms of wavy leading edges (WLEs) on a thin aerofoil undergoing vortical disturbances. This canonical study is based on a prescribed spanwise vortex travelling downstream and creating secondary vortices as it passes through the aerofoil’s leading edge. The primary aim of the study is to precisely understand the relationships between the vortex-induced velocity perturbation and the wall pressure fluctuation on the WLE geometry. It is observed that by increasing the size (amplitude) of the WLE the source strength at the peak region is reduced rapidly to a certain point, followed by a saturation stage, while at the root (trough) it remains fairly consistent regardless of the WLE size. This observation is demonstrated to be the consequence of three-dimensional vortex dynamics taking place along the WLE. One of the most profound features is that a system of horseshoe-like secondary vortices are created from the WLE peak region upon the impingement of the prescribed vortex. It is found that the horseshoe vortices produce a significantly non-uniform velocity perturbation in front of the WLE leading to the disparity in the source characteristics between the peak and root. The alterations to the impinging velocity perturbation are carefully analysed and related to the wall pressure fluctuation in this study. In addition, a semi-analytic model based on Biot–Savart’s law is developed to better understand and explain the role of the horseshoe vortex systems and the source mechanisms.
Stirring by periodic arrays of microswimmers
Authors: de Graaf Joost , Stenhammar Joakim
Published: December 2016

The interaction between swimming micro-organisms or artificial self-propelled colloids and passive (tracer) particles in a fluid leads to enhanced diffusion of the tracers. This enhancement has attracted strong interest, as it could lead to new strategies to tackle the difficult problem of mixing on a microfluidic scale. Most of the theoretical work on this topic has focused on hydrodynamic interactions between the tracers and swimmers in a bulk fluid. However, in simulations, periodic boundary conditions (PBCs) are often imposed on the sample and the fluid. Here, we theoretically analyse the effect of PBCs on the hydrodynamic interactions between tracer particles and microswimmers. We formulate an Ewald sum for the leading-order stresslet singularity produced by a swimmer to probe the effect of PBCs on tracer trajectories. We find that introducing periodicity into the system has a surprisingly significant effect, even for relatively small swimmer–tracer separations. We also find that the bulk limit is only reached for very large system sizes, which are challenging to simulate with most hydrodynamic solvers.
Parameter dependences of the onset of turbulent liquid-jet breakup
Authors: Kerstein Alan R. , Movaghar Amirreza , Oevermann Michael
Published: December 2016

Previous studies have predicted $We^{-2/5}$ dependence of the streamwise location at which primary breakup of turbulent liquid jets begins and $We^{-3/5}$ dependence of the Sauter mean diameter (SMD) of droplets released at that location, where $We$ is the jet Weber number. Measured deviations from these predictions were attributed to measurement uncertainties and to the simplicity of the analysis, which invoked turbulence inertial-range phenomenology. Here, it is proposed that breakup onset is instead controlled by the residual presence of the boundary-layer structure of the nozzle flow in the near field of the jet. Assuming that the size of the breakup-inducing eddy is within the scale range of the log-law region, $We^{-1}$ dependence of both the onset location and the SMD at onset is predicted. These dependences agree with the available measurements more closely than those previously predicted. To predict the dependences on the Reynolds number $Re$, either the friction velocity in conjunction with the Blasius friction law or the bulk velocity can be used, where the former yields $Re^{3/8}$ and $Re^{1/4}$ dependence of the onset location and the SMD at onset respectively, while the latter implies no $Re$ dependence of either. The latter result is consistent with the available measurements, but the boundary-layer analysis indicates that the velocity scaling should be based on the friction velocity rather than the bulk velocity, so the origin of the measured lack of $Re$ dependence merits further investigation. A plausible hypothesis is that pressure effects associated with the transition from wall-bounded nozzle flow to jet free-slip boundary conditions induce a transient large-scale flow modification that counteracts the $Re$ dependence of the nozzle flow while preserving the logarithmic flow structure near the jet surface. Notwithstanding the absence of direct evidence supporting this hypothesis, the new analysis and comparisons of its predictions with measurements suggest that transient effects such as the residual influence of the nozzle-flow structure are the likely explanations of the observed parameter dependences.
Factorial Validity of thePerceived Empathic and Social Self-Efficacy Scalefor Adults with Serious Mental Illness: A Brief Report
Authors: Sánchez Jennifer , Pfaller Joseph S. , Iwanaga Kanako , Chan Fong , Sung Connie , Bezyak Jill L. , Chen Shu-Mei
Published: December 2016

The objectives of this study were (1) to evaluate the measurement structure of thePerceived Empathic and Social Self-Efficacy Scaleamongst 194 individuals with serious mental illness (SMI) and (2) to establish construct validity for thePerceived Empathic and Social Self-Efficacy Scale. Confirmatory factor analysis yielded a two-factor measurement structure of thePerceived Empathic and Social Self-Efficacy Scale, which was positively associated with insight, social support, and life satisfaction. ThePerceived Empathic and Social Self-Efficacy Scaleis a useful measure to assess social skills amongst individuals with SMI in rehabilitation counselling.
Construct Validity of the EUROHIS-QOL for Rehabilitation Assessment
Authors: Perera Harsha N. , Athanasou James A.
Published: December 2016

The use of the EUROHIS as a brief measure of quality of life (QOL) in applied settings is increasingly commonplace, including in rehabilitation assessment contexts. However, there are concerns about the validity of data produced by the measure, chief amongst which is the latent structure underlying scores. This article reports on research conducted to investigate the dimensionality of scores derived from the EUROHIS. In addition, the factorial invariance of the retained model across gender as well as latent mean differences in QOL over age, employment status, and psychiatric severity were examined. Based on 251 responses to the EUROHIS by compensable accident victims, support was found for a complex one-factor model, which was found to be partially replicable across gender. Some evidence for differential item functioning across gender, age, and employment status was found. Finally, a U-shaped effect of age on QOL, characterized by a mid-life nadir, as well as effects of psychiatric severity on QOL, and a marginally significant effect of employment status were evident. Collectively, though the results of the present study yield validation data for the EUROHIS, they also raise concerns about the measure. We offer some tentative guidelines for working with the measure for both researchers and practitioners.
A ‘Rosetta Stone’ for Protoplanetary Disks: The Synergy of Multi-Wavelength Observations
Authors: Sicilia-Aguilar A. , Banzatti A. , Carmona A. , Stolker T. , Kama M. , Mendigutía I. , Garufi A. , Flaherty K. , van der Marel N. , Greaves J.
Published: December 2016

Recent progress in telescope development has brought us different ways to observe protoplanetary disks: interferometers, space missions, adaptive optics, polarimetry, and time- and spectrally-resolved data. While the new facilities have changed the way we can tackle open problems in disk structure and evolution, there is a substantial lack of interconnection between different observing communities. Here, we explore the complementarity of some of the state-of-the-art observing techniques, and how they can be brought together to understand disk dispersal and planet formation.

This paper was born at the ‘Protoplanetary Discussions’ meeting in Edinburgh, 2016. Its goal is to clarify where multi-wavelength observations converge in unveiling disk structure and evolution, and where they challenge our current understanding. We discuss caveats that should be considered when linking results from different observations, or when drawing conclusions from limited datasets (in terms of wavelength or sample). We focus on disk properties that are currently being revolutionized, specifically: the inner disk radius, holes and gaps and their link to large-scale disk structures, the disk mass, and the accretion rate. We discuss how their connections and apparent contradictions can help us to disentangle the disk physics and to learn about disk evolution.
The Rise of Synthetic Colors in the American Food Industry, 1870–1940
Authors: Hisano Ai
Published: December 2016

This article examines how, starting in the 1870s, food manufacturers in the United States began to use standardized color, achieved by synthetic dyes, as part of their marketing strategies. The emergence of the synthetic dye industry paralleled the growth of mass production and mass marketing in the American food industry. It provided food manufacturers with an economical means to standardize their products and helped establish brand identities through consistent appearance. By 1938, food dyes had achieved such widespread use, and had raised such public concern, that the federal government amended the 1906 Pure Food and Drug Act to implement more stringent measures to regulate the industry.
Thermochronology quantifying exhumation history of the Wudang Complex in the South Qinling Orogenic Belt, central China
Authors: SHEN CHUANBO , HU DI , SHAO CHUN , MEI LIANFU
Published: December 2016

The Wudang Complex located in the central part of South Qinling, has been inferred to be a segment of the Yangtze Craton involved in the orogen. In this study, the cooling/exhumation history of the Wudang Complex is revealed through combined published geochronology data and new apatite fission-track results. Three rapid exhumation episodes related to relevant geodynamic events have been identified. Previous40Ar–39Ar and (U–Th)/He data indicate that the most significant exhumation, induced by the collision between the North and South China Blocks, occurred fromc.237 to 220 Ma after long-term subsidence and sedimentation of the passive continental margin. The second exhumation event, related to the long-distance effect of the Pacific subduction, occurred during the period fromc.126 to 90 Ma. Following the late Cretaceous – Eocene peneplanation stage, the final late Cenozoic exhumation sincec.15 Ma may be attributed to the combined effect of the eastward growth of the Tibetan Plateau uplift and the Asian monsoon.
Freedom and Patronage in the Athenian Democracy
Authors: Alwine Andrew T.
Published: December 2016

To ask a question about ‘patronage’ is to view the issue from a top-down, broadly-conceived theoretical perspective. To understand Athenian political thought, we need to take an emic approach, to consider the perspective of the Athenian citizenry, which was concerned with present realities rather than complex, abstract models. The Athenian system's protection of individual citizens incidentally put broad restrictions on elite patronage, but, despite these limitations, relationships of patronage persisted throughout the Classical period albeit in non-threatening forms. Measures that ensured financial independence for the poor came only ad hoc and gradually. This article pursues three theses: (1) Athenians cared more about securing the freedoms of individual citizens than abolishing patronage, (2) patronage (as we would call it) existed in Athens but only in forms not threatening to civic freedoms and (3) in Athenian thinking political freedom was prior to financial independence. This article also explores the possibility of patronage systems existing in Greek poleis outside Athens, arguing that patronage-limiting practices were typical of democratic regimes but unusual for oligarchies.
Herodotus, Polycrates – and Maybe Stesimbrotus Too?
Authors: Pelling Christopher
Published: December 2016

The late fifth-century or sixth-century AD writer Fulgentius appears to quote Stesimbrotus of Thasos for a grisly detail of the death of Polycrates, describing how his corpse was carried away on a stretcher. Fulgentius is not a source to command confidence, and Jacoby dismisses this fragment as ‘unecht’ without further discussion. There is a case for being more cautious. It is not impossible that Stesimbrotus described Polycrates’ death, and, if so, Herodotus may be setting himself against that narrative when he says that Polycrates was killed ‘in a way which does not bear mentioning’. There may be a broader sense too in which both Herodotus and Thucydides are ‘defining their narratives against’ the work of Stesimbrotus among others.
Croesus and the Oracles
Authors: Thonemann Peter
Published: December 2016

Herodotus’ narrative of the testing of various Greek oracles by King Croesus of Lydia (1.46–54) has long been viewed with justifiable scepticism. A newly published verse dedication from the sanctuary of Apollo Ismenios at Thebes (Papazarkadas 2014: 233–48) sheds welcome light on Herodotus’ sources for this part of his Croesus-narrative. Herodotus’ account of Croesus’ testing of the oracle of Amphiaraus at Thebes appears to have been an imaginative extrapolation from the text of this inscription. But there is good reason to believe that Herodotus significantly misinterpreted the historical context and significance of the epigraphic text he had before him; in particular, the real author of the dedication is unlikely to have been King Croesus of Lydia, and may instead have been an Athenian aristocrat of the Alcmaeonid family. The new inscription from Thebes sheds light both on Herodotus’ use of documentary evidence and on the creative misreading of early epigraphic texts by Theban sanctuary personnel in the mid fifth century BC.
Redating Croesus: Herodotean Chronologies, and the Dates of the Earliest Coinages
Authors: Wallace Robert W.
Published: December 2016

The dates of Croesus’ reign, traditionally 560–546, derive mainly from the Nabonidus Chronicle, for Cyrus’ conquest of Lydia, and Herodotus 1.86.1, that Croesus ruled Lydia for 14 years. Part I of this essay questions the reliability of 1.86.1's ‘14’. Herodotus often uses formulaic or traditional numbers, including seven, for dating and elsewhere. Seven, twice seven, 14 and 70 recur frequently in the Croesus logos. Croesus’ reign may be a formulaic twice seven: seven prosperous years before Solon's visit, followed by seven disastrous years. It therefore may be unhistorical. Part II adduces other passages in Herodotus, and other evidence, that Croesus ruled Lydia already in the 580s. Nothing dates Alyattes after 585. Part III considers possible consequences of redating Croesus for the dates of early electrum and bimetallic coinages, the latter beginning perhaps in the 570s, as does Croesus’ Artemision at Ephesos. Part IV doubts what happened to Croesus when Sardis fell. Herodotus adapted one version for his own purposes. He probably invented Croesus’ role as wise warner to Cyrus and Cambyses.
Listening While Muslim
Authors: Zuberi Nabeel
Published: December 2016

You are what you hear, not what you say. This personal reflection explores how listening to music in the post 9/11 context enabled me to negotiate ideas of diasporic Muslim identity when speaking as Muslim proved much more difficult. Islamophobia and Islamophilia both apply pressures on the kind of Muslim one can be in public. Listening to electronic music genres, hip hop and punk from the US and UK opened up spaces to engage with war and terror, racism and media. Much of this music refers directly to Muslim peoples, places and structures of feeling. Yet music that isn't explicit about the Muslim is also conscripted for life during wartime in which some of us feel wary about articulating those Muslim parts of our garbled selves. Music genres have specific affordances that modulate Muslim affects and discourses, and shape new and indeterminate ways of being Muslim.
Playing with time: Kate Bush's temporal strategies and resistant time consciousness
Authors: Withers D-M
Published: December 2016

This article focuses on two of Kate Bush's post-Aerial(2005) albums:Director's Cut(2011) and50 Words for Snow(2011). In these albums Bush plays with the temporal qualities of recorded music to create the conditions forself-reflexiveinternal time consciousness to emerge within the listener. I argue that self-reflexive internal time consciousness is a process that enables a listener to gain some understanding that they are embroiled in an act of perception forged via active engagement with recorded music. Bush creates these conditions in two principle ways: InDirector's Cutshe disturbs the memory of previous recorded versions that are re-visited on the album so they can be mobilised as new, interpretative-perceptive acts. In50 Words for Snowshe uses duration as a structure to support the construction of extensive perception. Bush plays with time on these albums because her conceptual music relies upon the uninterrupted unfolding of consciousness as it becomes interlaced with her recordings, understood in the Husserlian sense of temporal objects. Implicit to her temporal strategies is a critique of contemporary listening conditions and how they undermine the very forging of the perceptual act.
The Privilege Against Self-Incrimination in Truth Commission-Administered Accountability Initiatives
Authors: BISSET ALISON
Published: December 2016

In recent times, transitional justice practice has increasingly seen truth commissions tasked with administering accountability programmes, distinct from, and in addition to, their traditional truth-seeking role. Such accountability schemes typically take the form of granting or recommending amnesty for those who disclose involvement in past crimes or facilitate reintegration on the basis of similar disclosures. Self-incriminating disclosures made in the course of traditional truth commission proceedings generally attract a robust set of legal safeguards. However, the protections within transitional accountability schemes administered by truth commissions tend to be less stringent. This article explores this anomaly, focusing particularly on the extent to which the privilege against self-incrimination is protected within truth commission-administered accountability programmes. It considers the programmes operated to date, and the levels of protection afforded, and demonstrates a lack of consistent practice in the safeguarding of individual rights within these programmes. It examines international legal standards on the privilege against self-incrimination and questions whether the procedures operated by accountability programmes can be reconciled with international norms in order to protect those who make self-incriminating disclosures within accountability initiatives. The article argues that a failure to ensure individual rights against self-incrimination risks compromising the efficacy of the programmes themselves and the contribution that they can make to long-term peace and reconciliation in transitional states.
Recalibrating Defensive Killing: Liability, Mere Permissibility, and the Problem of Multiple Threats
Authors: CHEHTMAN ALEJANDRO
Published: December 2016

The concept of liability is currently at the centre of contemporary debates on interpersonal defensive killing and war. This often leads to radically asymmetrical moral positions between aggressors and victims, and between just and unjust combatants. This article argues that the dichotomy liable/non-liable is too rigid to adequately capture the moral landscape in many relevant defensive killing situations. By contrast, it proposes a more granulated framework that takes seriously both the conceptual features of rights as essentially individualistic entities and their strength in moral reasoning. Finally, the article also shows that far from creating problems for the morality of killing in war, the proposed framework allows us to better accommodate for the position of unjust combatants than standard revisionist accounts of just war theory.
STATUS PREFERENCE AND THE EFFECTS OF PATENT PROTECTION: THEORY AND EVIDENCE
Authors: Pan Shiyuan , Zhang Mengbo , Zou Heng-Fu
Published: December 2016

We construct a growth model with status preference to explore the effects of patents on innovation and social welfare. We find a nonmonotonic effect of patent protection on innovation. Additionally, the growth-rate-maximizing degree of patent protection decreases when the strength of status preference is larger. The effect of patent protection on social welfare is ambiguous, depending on the strength of status preference. Moreover, wealth inequality widens as patent protection is reinforced. Finally, by using cross-section regression analysis, we document that a nonmonotonic relationship between patent protection and economic growth is statistically significant and that the growth-rate-maximizing degree of patent protection decreases with the strength of status preference.
On the bilingualism effect in task switching
Authors: BRANZI FRANCESCA M. , CALABRIA MARCO , GADE MIRIAM , FUENTES LUIS J. , COSTA ALBERT
Published: December 2016

In one task-switching experiment, we compared bilinguals and monolinguals to explore the reliability of the bilingualism effect on the n-2 repetition cost. In a second task-switching experiment, we tested another group of bilinguals and monolinguals and measured both the n-1 shift cost and the n-2 repetition cost to test the hypothesis that bilingualism should confer a general greater efficiency of the executive control functioning. According to this hypothesis, we expected a reduced n-1 shift cost and an enhanced n-2 repetition cost for bilinguals compared to monolinguals. However, we did not observe such results. Our findings suggest that previous results cannot be replicated and that the n-2 repetition cost is another index that shows no reliable bilingualism effect. Finally, we observed a negative correlation between the two switch costs among bilinguals only. This finding may suggest that the two groups employ different strategies to cope with interference in task-switching paradigms.
Prudent Deferment: Cosmographer-Chronicler Juan López de Velasco and the Historiography of the Indies
Authors: Ruan Felipe E.
Published: December 2016

The article examines why the first Chief Cosmographer-Chronicler of the Indies, Juan López de Velasco (c. 1530–1598), did not fulfill his historiographic duty of writing a general history of the Indies. It argues that although Velasco's tenure (1571-1591) at the Council of the Indies saw a high point in the accumulation of historiographic knowledge and information about Castile's Spanish-American possessions, the structural peculiarities of the cosmographer-chronicler's office disposed Velasco to prudently eschew writing an official history of the Indies. To appreciate and understand those peculiarities, the article focuses on three interrelated factors: the patronage networks at the royal court and their relation to monarchical bureaucracy; the Council of the Indies administrative reforms that led to the creation of the chief cosmographer-chronicler's office; and the climate of secrecy and censorship regarding knowledge of the Indies during Philip II's reign. The overarching emphasis, however, entails a consideration of the relationship between knowledge about Castile's American territories and monarchical bureaucracy, from the perspective of the Habsburg royal court in Madrid.
Earth's Ground Heat Flux Should Not Be Overlooked
Authors: Underwood Emily
Published: December 2016

Scientists compare models of how much heat Earth's surface gives off and absorbs from the atmosphere.
Suppression of CRTC2-mediated hepatic gluconeogenesis by TRAF6 contributes to hypoglycemia in septic shock
Authors: Lv Sihan , Qiu Xinchen , Li Jian , Li Weida , Zhang Chao , Zhang Zhen-Ning , Luan Bing
Published: December 2016

Although hypoglycemia has been documented as a major cause of high mortality in the setting of septic shock, the mechanism of hypoglycemia in infection has not been clearly determined. Hepatic gluconeogenesis serves as an important mechanism to maintain glucose levels under physiological conditions and CREB coactivator CRTC2 plays an important role in regulating gluconeogenic gene expression. Here, we show that triggering of the Toll-like receptor 4 pathway in response to endotoxin lipopolysaccharide (LPS) inhibits gluconeogenic gene expression and hepatic glucose output by blocking CRTC2 activation. Interleukin-1β (IL-1β) is found to disrupt gluconeogenic gene expression via the activation of the E3 ubiquitin ligase TRAF6, a key component of the Toll-like receptor 4 signaling pathway that associates with and ubiquitinates CRTC2. TRAF6 promotes the K63-linked ubiquitination of CRTC2, a modification that blocks binding of calcineurin at an adjacent calcineurin-binding site, thereby disrupting CRTC2 dephosphorylation in response to glucagon signals. Mutation of TRAF6-binding sites or ubiquitination site in CRTC2 rescues hepatic gluconeogenesis in LPS-challenged mice. These results suggest that pro-inflammatory signals intersect with the CRTC2 pathway in liver, thus contributing to hypoglycemia caused by infection.
The seahorse genome and the evolution of its specialized morphology
Authors: Lin Qiang , Fan Shaohua , Zhang Yanhong , Xu Meng , Zhang Huixian , Yang Yulan , Lee Alison P. , Woltering Joost M. , Ravi Vydianathan , Gunter Helen M. , Luo Wei , Gao Zexia , Lim Zhi Wei , Qin Geng , Schneider Ralf F. , Wang Xin , Xiong Peiwen , Li Gang , Wang Kai , Min Jiumeng , Zhang Chi , Qiu Ying , Bai Jie , He Weiming , Bian Chao , Zhang Xinhui , Shan Dai , Qu Hongyue , Sun Ying , Gao Qiang , Huang Liangmin , Shi Qiong , Meyer Axel , Venkatesh Byrappa
Published: December 2016

Seahorses have a specialized morphology that includes a toothless tubular mouth, a body covered with bony plates, a male brood pouch, and the absence of caudal and pelvic fins. Here we report the sequencing andde novoassembly of the genome of the tiger tail seahorse,Hippocampus comes. Comparative genomic analysis identifies higher protein and nucleotide evolutionary rates inH. comescompared with other teleost fish genomes. We identified an astacin metalloprotease gene family that has undergone expansion and is highly expressed in the male brood pouch. We also find that theH. comesgenome lacks enamel matrix protein-coding proline/glutamine-rich secretory calcium-binding phosphoprotein genes, which might have led to the loss of mineralized teeth.tbx4, a regulator of hindlimb development, is also not found inH. comesgenome. Knockout oftbx4in zebrafish showed a ‘pelvic fin-loss’ phenotype similar to that of seahorses.