bluuebunny/crossref_metadata_2025 huggingface dataset:
A practical guide to address reactions to vaccines in children
Authors: Arcolaci Alessandra , Scarmozzino Rocco , Zanoni Giovanna
Published: March 2023

Currently available vaccines are safe but, potentially, any vaccine can
cause an allergic reaction and albeit very rare, anaphylaxis can occur.
Although its rarity, the precise diagnostic management of a suspected
anaphylaxis post-vaccination is of paramount importance due to the risk
of a potential serious reactions after re-exposure, while, a
misdiagnosis might lead to an increase in the number of children that
interrupt vaccinations resulting in an unjustifiably individual and
collective risk of loss of protection against immune preventable
diseases. Especially, in the light that most cases of suspected allergy
to a vaccine are not effectively confirmed in up to 85% of the patients
referred for an allergy evaluation and patients can continue vaccination
with the same formulation and tolerance of the booster doses The patient
assessment has to be done by an allergist or an immunologist expert in
the vaccine field to select subjects at risk of allergic reactions and
to perform the correct procedures for vaccine hypersensitivity diagnosis
and management, in order to guarantee safe immunization practices. Aim
of this review is to provide a practical and safe management in the
clinical settings of the allergic patient which have to undergo
immunization practices, both to manage children with a suspected
allergic reaction to a vaccine both children with history of allergy to
a vaccine component.
Guillain-Barre syndrome associated with COVID-19 and malaria coinfection: A case report
Authors: Ahmed Ayman , EL-SADIG Dr. SARAH MISBAH , Eltigani Hala , Siddig Emmanuel
Published: March 2023

We reported the first case of Guillain-Barré syndrome that is associated
with COVID-19 and malaria coinfection. The current report demonstrates
diagnostic challenge to identify GBS case in a country like Sudan that
is endemic with several infectious diseases associated with developing
GBS.
Detecting Cold Pool Family Trees in Convection Resolving Simulations
Authors: Hoeller Jannik , Fiévet Romain , Haerter Jan O
Published: March 2023

Recent observations and modeling increasingly reveal the key role of
cold pools in organizing the convective cloud field. Several methods for
detecting cold pools in simulations exist, but are usually based on
buoyancy fields and fall short in reliably identifying the active gust
front. The current algorithm, termed CoolDeTA, aims to detect and track
cold pools along with their active gust fronts and the “offspring”
rain cells generated nearby. We show how CoolDeTA can reconstruct cold
pool family trees. Using it allows us to contrast RCE and diurnal cycle
cold pool dynamics, as well as cases with vertical wind shear and
without. The results suggest a conceptual model where cold pool
triggering of children rain cells follows a simple birth rate, which is
proportional to a cold pool’s gust front length. The proportionality
factor depends on the ambient atmospheric stability and is lower for
RCE, in line with marginal stability as traditionally ascribed to the
moist adiabat. In the diurnal case, where ambient stability is lower,
the birth rate thus becomes substantially higher, in line with periodic
insolation forcing — resulting in essentially run-away mesoscale
excitations generated by a single parent rain cell and its cold pool.
Analiza trwania pracy zdalnej w czasie pandemii COVID-19
Authors: Andrychowska Anna , Lipiński Paweł
Published: February 2023

W wyniku zagrożenia epidemicznego związanego z rozprzestrzenianiem się choroby zakaźnej COVID-19 wprowadzono wiele rozwiązań mających na celu zapewnienie dystansu społecznego. W obszarze rynku pracy takim rozwiązaniem stała się praca zdalna. Celem artykułu jest analiza czasu trwania pracy w formie zdalnej oraz zbadanie wpływu wybranych zmiennych na czas przeżycia. W badaniu wykorzystano estymator Kaplana-Meiera oraz model regresji Coxa. Dane pochodzą z badania ankietowego zrealizowanego przez autorów w 2021 roku. Przeprowadzona analiza dostarczyła informacji na temat charakterystyk grup bardziej narażonych na ryzyko rezygnacji z pracy zdalnej i powrotu do pracy w formie stacjonarnej. Zmienne takie jak rodzaj organizacji, płeć i wiek mogą być według przeprowadzonych badań postrzegane jako determinanty czasu świadczenia pracy w formie zdalnej.
Predicting smart cities’ electricity demands using k-means clustering algorithm in smart grid
Authors: Wang Shurui , Song Aifeng , Qian Yufeng
Published: March 2023

This work aims to perform the unified management of various departments engaged in smart city construction by big data, establish a synthetic data collection and sharing system, and provide fast and convenient big data services for smart applications in various fields. A new electricity demand prediction model based on back propagation neural network (BPNN) is proposed for China?s electricity industry according to the smart city?s big data characteristics. This model integrates meteorological, geographic, demographic, corporate, and economic information to form a big intelligent database. Moreover, the K-means clustering algorithm mines and analyzes the data to optimize the power consumers? information. The BPNN model is used to extract features for prediction. Users with weak daily correlation obtained by the K-means clustering algorithm only input the historical load of adjacent moments into the BPNN model for prediction. Finally, the electricity market is evaluated by exploring the data correlation in-depth to verify the proposed model?s effectiveness. The results indicate that the K-mean algorithm can significantly improve the segmentation accuracy of power consumers, with a maximum accuracy of 85.25% and average accuracy of 83.72%. The electricity consumption of different regions is separated, and the electricity consumption is classified. The electricity demand prediction model can enhance prediction accuracy, with an average error rate of 3.27%. The model?s training significantly speeds up by adding the momentum factor, and the average error rate is 2.13%. Therefore, the electricity demand prediction model achieves high accuracy and training efficiency. The findings can provide a theoretical and practical foundation for electricity demand prediction, personalized marketing, and the development planning of the power industry.
Pedestrian attribute recognition based on dual self-attention mechanism
Authors: Fan Zhongkui , Guan Ye-Peng
Published: March 2023

Recognizing pedestrian attributes has recently obtained increasing attention due to its great potential in person re-identification, recommendation system, and other applications. Existing methods have achieved good results, but these methods do not fully utilize region information and the correlation between attributes. This paper aims at proposing a robust pedestrian attribute recognition framework. Specifically, we first propose an end-to-end framework for attribute recognition. Secondly, spatial and semantic self-attention mechanism is used for key points localization and bounding boxes generation. Finally, a hierarchical recognition strategy is proposed, the whole region is used for the global attribute recognition, and the relevant regions are used for the local attribute recognition. Experimental results on two pedestrian attribute datasets PETA and RAP show that the mean recognition accuracy reaches 84.63% and 82.70%. The heatmap analysis shows that our method can effectively improve the spatial and the semantic correlation between attributes. Compared with existing methods, it can achieve better recognition effect.
Adaptive multiscale sparse unmixing for hyperspectral remote sensing image
Authors: Li Yalan , Du Qian , Li Yixuan , Xie Wenwu , Yuan Jing , Li Lin , Qi Chen
Published: March 2023

Sparse unmixing of hyperspectral images aims to separate the endmembers and estimate the abundances of mixed pixels. This approach is the essential step for many applications involving hyperspectral images. The multi-scale spatial sparse hyperspectral unmixing algorithm (MUA) could achieve higher accuracy than many state-of-the-art algorithms. The regularization parameters, whose combinations markedly influence the unmixing accuracy, are determined by manually searching in the broad parameter space, leading to time consuming. To settle this issue, the adaptive multi-scale spatial sparse hyperspectral unmixing algorithm (AMUA) is proposed. Firstly, the MUA model is converted into a new version by using of a maximum a posteriori (MAP) system. Secondly, the theories indicating that andnorms are equivalent to Laplacian and multivariate Gaussian functions, respectively, are applied to explore the strong connections among the regularization parameters, estimated abundances and estimated noise variances. Finally, the connections are applied to update the regularization parameters adaptively in the optimization process of unmixing. Experimental results on both simulated data and real hyperspectral images show that the AMUA can substantially improve the unmixing efficiency at the cost of negligible accuracy. And a series of sensitive experiments were undertook to verify the robustness of the AMUA algorithm.
Experimental study on the mechanism of water affecting the permeability characteristics of sandstone
Authors: Gao Heng , Zhang Zhi-Long , Lu Jun , Zhang Ze-Tian
Published: March 2023

The permeability characteristics of sandstone are of great importance for
un-conventional natural gas extraction, CO2 geological storage, coal mine
gas safety, etc. Under the influence of tectonic stress and mining-induced
stress, the evolution of permeability becomes exceptionally complex. A
number of studies have focused on the evolution of permeability under
different stress paths, ignoring the effect of water on sandstone
permeability. The permeability evolution of sandstone in dry and saturated
states under high and low surrounding pressures was investigated by triaxial
tests. The results show that the triaxial compressive strength of the
specimen significantly decreases under saturated conditions. Specifically,
the triaxial compressive strength decreases by 27.12% and 10.52% under low
and high confining pressure, respectively. Compared to the dry specimen, the
permeability of the saturated specimen significantly decreases at all
stages of loading, the initial permeability of the saturated specimen is
decreased by 92.09% and 56.25% at low and high confining pressure,
respectively. The S&D model was matched with the test data, an excellent
goodness of fit was obtained in the elastic and plastic phase, and the
mechanism of water affecting sandstone permeability was analyzed.
Estimation of shallow geothermal potential to meet heating demand in a building scale
Authors: Wang Yi-Tong , You Shuang , Hou Xiao-Xu , Yi Zheng
Published: March 2023

The heat exchanger can use shallow geothermal energy to provide regional
heating and cooling demand in winter and summer. In this paper, a
large-scale public building is taken as the example, and the energy system
in the building is taken as the research object. Firstly, through the
collection of geothermal drilling geographic information and geothermal
data, the geothermal reserves and geothermal recoverable resources are
evaluated. Secondly, the cooling and heating demand of the building is
calculated by using HVAC simulation software. Then, the heat transfer
capacity of a single pile is evaluated and the layout scheme of the
underground heat exchange pile foundation of the building is given. The
actual heating effect of the heat exchange pile foundation system is
explored, and the heat transfer characteristics of heat exchange pile
foundation under different working conditions are compared and analyzed.
Finally, reasonable suggestions for the arrangement of heat exchange pile
foundation are given.
Discrete element analysis on the influence of drilling fluid pressure on core discing in pressure-preserved coring
Authors: Wang Ding-Ming , Chen Ling , Guo Da , Liu Zhi-Qiang , Li Ju , Yang Xun , Zhang Yi-Wei
Published: March 2023

In the process of coring in a high in-situ stress environment, the rock core
is damaged due to stress release, and core discing is a prominent
manifestation of this damage. Pressure-preserved coring has no direct effect
on in-situ stress, and its influence on stress release is related to
drilling fluid pressure. Yet fluid pressure in the coring process was not
considered in most former numerical simulation studies on core discing. In
this paper, the discrete element method software PFC3D is used to conduct a
numerical simulation of the coring process. According to the two conditions
without drilling fluid pressure and with it, and different horizontal
in-situ stresses of 5-160 MPa, fracture and discing of the core with
drilling are observed. In addition, the law of fracture and discing in the
process of coring was studied, and the function of pressure-preserved coring
to prevent fracture and discing is explored. Simulation results show
nonlinear trends in distribution of discs both in time and in space.
Field experimental study on comprehensive dust control technology in fully mechanized caving face of extra thick coal seam
Authors: Zhao Li-Juan , Li Ying , Duan Hong-Fei
Published: March 2023

In order to solve the dust treatment problem of the coal Permian extra thick
coal seam mined by Tashan Coal Mine, the comprehensive dust treatment
technology research was carried out with the 8106 comprehensive discharge
face and 8210 comprehensive discharge face of Tashan Coal Mine as the
geological background, and the four aspects of coal seam water injection
process, determination of water injection parameters, inspection of water
injection and dust reduction effect and application promotion prospects were
analyzed and studied.
Temporal second-order finite difference schemes for variable-order time-fractional generalized Oldroyd-B fluid model
Authors: Wang Fang , Peng Xin-Yu , Shen Wang-Cheng
Published: March 2023

In this paper, we study the variable-order generalized time fractional
Oldroyd-B fluid model, use the reduced order method and the L2-1? method to
establish the differential format with second-order accuracy, prove the
stability and convergence of the format, and give numerical examples to
illustrate the effectiveness of the differential format.
Tirzepatide Reduces Appetite, Energy Intake, and Fat Mass in People With Type 2 Diabetes
Authors: Heise Tim , DeVries J. Hans , Urva Shweta , Li Jing , Pratt Edward J. , Thomas Melissa K. , Mather Kieren J. , Karanikas Chrisanthi A. , Dunn Julia , Haupt Axel , Milicevic Zvonko , Coskun Tamer
Published: March 2023

OBJECTIVE

To evaluate the effects of tirzepatide on body composition, appetite, and energy intake to address the potential mechanisms involved in body weight loss with tirzepatide.

RESEARCH DESIGN AND METHODS

In a secondary analysis of a randomized, double-blind, parallel-arm study, the effects of tirzepatide 15 mg (N = 45), semaglutide 1 mg (N = 44), and placebo (N = 28) on body weight and composition, appetite, and energy intake were assessed at baseline and week 28.

RESULTS

Tirzepatide treatment demonstrated significant reductions in body weight compared with placebo and semaglutide, resulting in greater fat mass reduction. Tirzepatide and semaglutide significantly reduced appetite versus placebo. Appetite scores and energy intake reductions did not differ between tirzepatide and semaglutide.

CONCLUSIONS

Differences in energy intake during ad libitum lunch were not sufficient to explain the different weight outcomes. Further evaluation is needed to assess mechanistic differences related to tirzepatide actions on 24-h energy intake, substrate utilization, and energy expenditure.
Long-term follow-up of 96 patients younger than age 25 with 119 primary cemented total hip arthroplasties
Authors: Özdemir Erim , Kuijpers Martijn F L , Schreurs B Willem , Rijnen Wim H C
Published: March 2023

Background and purpose: Long-term follow-up of young patients following cemented primary THA is scarce. Therefore, we analyzed the survival of all consecutive primary THAs in patients under 25 years performed at our institute.Patients and methods: All primary THAs performed in patients younger than 25 years in our tertiary care institute between 1988 and 2015 were included (n = 119). Cemented fixation was used in all patients. In the case of acetabular bone deficiencies, reconstruction was performed using impaction bone grafting (IBG). We used Kaplan–Meier analysis to determine the survival of the primary THA with endpoints revision for any reason and aseptic loosening.Results: The mean age at the primary THA was 20 years. The most prevalent diagnosis was avascular necrosis (31%). The mean follow-up of the primary THA was 11 years (range 0–32). 2 patients (2 hips) were lost to follow-up. 16 revisions were registered. The survival of any component for endpoint revision for any reason was estimated at 92% (95% confidence interval [CI] 84–96) and 81% (CI 67–90) at 10- and 15-year follow-up, respectively. The survival of any component for endpoint revision for aseptic loosening was 99% (CI 93–100) and 88% (CI 71–95) at 10 and 15 years, respectively. 3 hips were revised due to infection.Conclusion: Favorable long-term outcomes of primary THA in very young patients can be obtained using cemented fixation and IBG.
The Superstition that Enslaves Virgin Girls in Ghana: An Exploration of the Origins, Evolution, and Practice of Trokosi
Authors:   Aberystwyth University, Wales, Owusu Emmanuel Sarpong
Published: March 2023

Trokosi is a religious practice in some parts of West Africa where young virgin girls are sent to fetish shrines to become sex slaves as part of rituals meant to prevent a communal calamity supposedly provoked by the transgressions of members of the girls’ family. This study offers additional insight into the concept, origins, evolution, and practice of trokosi, highlighting the cultural, socio-economic, and legal contexts of this practice in Ghana. This goal is achieved by reviewing pertinent literature and interviewing 10 participants: academics; activists; traditional leaders; and ordinary community members. The study establishes that trokosi, which is viewed by adherents as a religious practice and crime prevention mechanism, is a severe violation of girls’ fundamental rights. It is the epitome of sexual violence against young females and the worst form of child enslavement, discrimination, oppression, and physical and psychological torture in the south-eastern part of Ghana. It notes that even though the practice has been outlawed, it still thrives due largely to illiteracy, ineffective enforcement mechanisms, and lack of political will on the part of the government. It suggests that the ills of the trokosi system can be suppressed not through legislative actions alone but through a multi-pronged approach.
Holmes' Reformulation Through Elements of Feminist in Enola Holmes
Authors:   Master Program of Literature, Faculty of Cultural Sciences, Sampe Marssy Diana
Published: March 2023

As time goes by, fiction has become a medium that satisfies people’s wishes. This phenomenon happens because the purpose of popular fiction is to fulfill people's demands of plot lines. Therefore, the storyline or narrative of the story is a crucial point in discussing popular fiction. Genre becomes the key point in discussing the formulation of a story. This formulation is based on convention and one of the famous formulations is the genre of detective. One of the famous works of detectives is Sherlock Holmes. Holmes has created his own world and has produced so many adaptations. One of the adaptations that hooked people's attention is a spin-off work of Sherlock Holmes, Enola Holmes. Enola Holmes is a novel series written by Springer that got recognition from many people because she wrote a story on the line of Sherlock Holmes’s canonical story. Due to the fame, this series got adapted into film as Jack Thorne rewrote the story based on the original. However, Enola—written by Springer and Thorne—represents a contra point in the formulation. In order to discover and prove the formulation, this study focuses on using genre critcisim focusing on the formulation of feminist in the objects. Furthermore, this study also uses genre theories by Cawelti and Gelder in conducting the discussion. This research proves that Enola is a detective story by following the classical detective formula following the original formulation by Doyle on Sherlock. The problem of contra point is represented in the invention or innovation of the detective genre as it is taking women as the detective and main villain and a mystery around women characters.
PERSEPSI SISWA TERHADAP PEMBELAJARAN ONLINE PADA MATA PELAJARAN SEJARAH DI KELAS X IPS MAN 2 BANDAR LAMPUNG
Authors: Sari Ririn Novita , M Syaiful , Rachmedita Valensy
Published: March 2023

Penelitian ini bertujuan untuk mengetahui Persepsi Siswa terhadap Pembelajaran Online Pada Mata Pelajaran Sejarah di Kelas X IPS MAN 2 Bandar Lampung. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif deskriptif, informan yang dijadikan objek penelitian adalah Siswa Kelas X IPS MAN 2 Bandar Lampung. Teknik Pengumpulan data menggunakan teknik kuisioner atau angket, wawancara, dokumentasi dan studi kepustakaan. Teknik analisis data yang digunakan adalah Teknik analisis data yang digunakan dalam penelitian ini menggunakan teknik kuantitatif deskriptif. Hasil penelitian ini disimpulkan bahwa persepsi siswa terhadap pembelajaran online pada mata pelajaran sejarah di kelas X IPS MAN 2 Bandar Lampung termasuk kategori kurang positif, dengan perolehan skor rata-rata sebesar 77,74 dengan persentase skor 62,19% dari masing-masing indikator bahwa sebagian besar siswa memiliki persepsi yang kurang positif terhadap pembelajaran online pada mata pelajaran sejarah baik dari aspek keterarikan (Presentase 47,37%), motivasi (Presentase 57,89%), kepuasan (Presentase 65,79%), penilaian (Presentase 52,63%), dan tanggapan (Presentase 65,79 %).
System Dynamics Modeling of Multi-Channel Supply Chain System: A Hypothetical LPG Distribution with Disloyal Household Customers
Authors: Murdapa Petrus Setya , Karningsih Putu Dana , Pujawan I Nyoman
Published: March 2023

The availability of LPG in the community is a sensitive issue. If there is a shortage, it has the potential to cause chaos and inflation. The final consumers, namely households and micro business stalls, will generally be disloyal. They are not tied to one particular store to get the LPG they need. Since the number of tanks in circulation will remain constant, the analysis of LPG availability can be focused on the number of tanks. Continuous simulation method with system dynamics is generally used in system growth analysis. In this paper the method is utilized to model the discrete movement of tanks circulating in the community which in this case is represented in a much smaller system, consisting of filling stations, agents, and stores. The modeling results provide a sufficient picture of how the availability of the tank can be optimized appropriately.
Implementation of Group-Based Human Movement Model in Opportunistic Network
Authors: Ayu Vittalis , Soelistijanto Bambang
Published: March 2023

As an instance of a distributed computing system, opportunistic networks facilitate message dissemination in a store-carry-forward manner. In this setting, the mobile devices are communicating in opportunistic contacts as they move across the network areas. However, the movement of these mobile devices is exclusively reliant on the mobility of their human owner, thereby limiting the likelihood of contact. The current state of the art typically simulates human movement based on randomness, which is unsuitable for representing how people move in groups. Therefore, this paper proposes an implementation of a group-based human mobility model to simulate device-to-device communication in opportunistic networks. In this model, individuals are able to move as a set within a group and have the ability to join and leave the group dynamically We built the model in BonnMotion and subsequently implemented it in an opportunistic environment simulator, ONE Simulator. To evaluate the proposed model, we compared them to the random-based model as a benchmark. Subsequently, we assess the impact of the movement model on two major areas of network performance: message delivery performance and resource utilization, such as nodes’ energy consumption. We are concerned about these aspects since the mobile agents have limited resources yet are expected to achieve a high rate of message delivery as well. The simulation results show that our model outperformed the random-based model in terms of the number of successfully delivered messages and average delay. However, the number of message replications and the energy consumption is fairly higher than those of the benchmarks.
Priority Scheduling Implementation for Exam Schedule
Authors: Yanwari Muhammad Irwan , Prabuwono Anton Satria , Yudantoro Tri Raharjo , Aji Nurseno Bayu , Wiktasari  , Handoko Slamet
Published: March 2023

Scheduling is a common problem that has been raised for a long time. Many algorithms have been created for this problem. Some algorithms offer flexibility in terms of constraints and complex operations. Because of that complexity, many algorithms will need huge computation resources and execution time. A platform like a web application has many restrictions such as execution time and computation resources. A complex algorithm is not suited for the web application platform. Priority scheduling is a scheduling algorithm based on a priority queue. Every schedule slot will produce a queue based on the constraints. Each constraint will have a different weight. Weight in queue represents their priority. This algorithm provides a light algorithm that only needs a few computations and execution times. The exam schedule is one of many problems in educational institutions. A web application is a popular platform that can be accessed from everywhere. Many educational institutions use web platforms as their main system platform. Web platforms have some restrictions such as execution time. Due to web platform restrictions, priority scheduling is a suitable algorithm for this platform. In this study, the author tries to implement a priority scheduling algorithm in scheduling cases with a website platform and shows that this algorithm solution can be an alternative for solving scheduling cases with low computational resources.
A Pragmatic Approach to Anemia in Pregnancy: An Overview
Authors: Thurairasu Vanitha , Marimuthoo Puspa , Kumareswaran Suriya
Published: March 2023

Anemia is a common condition in pregnancy and has been associated with various adverse maternal and fetal outcomes. Hematological parameters are altered as a result of normal physiological changes during pregnancy, most notably a decrease in hemoglobin (Hb) concentration. As iron demands during pregnancy increases tremendously, it is not surprising that iron deficiency anemia is still the most common cause of anemia. Indeed, a mother's overall health and her ability to work can be negatively impacted by chronic iron deficiency, which also causes weariness. In order to assess the iron status, laboratory investigations are advised to start in the first trimester. Early identification and treatment of this clinical disease are essential because of the condition's severe negative effects on maternal-fetal outcomes. This calls for effective and immediate preventative measures to avoid further complications that may lead to maternal and fetal morbidity and mortality. This review serves as a brief to approach anemia in pregnancy. It provides an overview on understanding the problem and suggests recommendations to decrease the prevalence.
The Role of Rural Indian Women in Livestock Production
Authors: Vijayalakshmy Kennady , Chakraborty Sharmistha , Biswal Jyotsnarani , Rahman Habibar
Published: March 2023

India is an agriculturally based nation, and a significant portion of its livestock sector is controlled by women. Women have a lot of options to increase their income by working in the livestock sector. Livestock provides meat, milk, eggs, and other food products, which are generally considered key assets for rural livelihood, that are dietary staples for population. For the women's livelihood and to help ensure the food security of the household, livestock is a crucial non-land productive asset. The tiny, marginal, and landless farmers in rural areas are the owners of more than 70% of the livestock. Compared to male workers, self-employed women are more likely to work in livestock production. Women add value and market the majority of animal farming activities, including fodder collection, feeding, watering, health care, animal management, milking, and household-level processing. Although rural women have a significant role in livestock management activities, however, their participation is low in certain decision-making activities. The present review elaborates in detail on the contribution of women in livestock management activities, different constraints faced by them in the livestock sector, and different areas where successful interventions can be undertaken to address the challenges faced by women in the livestock sector.
The Differences of The Feeling Case in Romantic Relations
Authors: Bal Fatih
Published: March 2023

This research aims to examine emotional differences in romantic relationships. The relational screening model used this research. The population of this research consists of adult individuals living in Istanbul. The sample of the study consists of 600 adult individuals selected by random sampling method among these individuals. This study used the Demographic Information Form, Relationship Rating Scale, and Mood State Adjective Pairs List as data collection tools. Significant differences between the Relationship Rating Scale and the Mood State Adjective Pairs List were found between meaningful relationships and gender variables. In addition, it was determined that the Mood Pairs List Relationship Evaluation Scale predicted significantly, and Mood Pairs List Relationship Evaluation Scale explained 97.1% of the total variance. According to beta coefficient values, it was found that the variable that describes the effect of relationship satisfaction the most is Joyful-Sad.
Rancang bangun mesin pengering buah pinang tipe rotari dengan sumber panas api kompor berbahan bahar oli bekas
Authors: Syahrizal Iman Iman , Butsi Ningsih Irma Fahrizal , Kurniawan Kurniawan
Published: March 2023

This study aims to describe the working system and test the performance of the machine, to find out an overview of reducing the moisture content of betel nut dried with a rotary type betel nut dryer machine with a heat source from a used oil-fueled stove fire. The methods used in the study consist of the design stage and the performance test stage. The design stage was to carry out the construction design process, material selection, and fabrication process. While the performance test stage aims to determine the ability of the machine to carry out the betel nut drying process. The results of the design of the rotary type betel nut dryer machine consist of a heating system and a drive system. The heating system uses heat from the used oil-fueled stove and the drive system uses an electric motor connected to the reducer gearbox to rotate the cylinder of the drying chamber. The maximum air temperature generated during the 7-hour performance test process was 108oC with an air flow speed of 3,8 m/s. The results of the design of the drying machine are able to reduce fruit mass by 5.5 kg with a drying rate of 0.785 kg / hour on wet betel nut. The reduction in the moisture content of dried betel nut is directly proportional to the reduction in mass. During the 7-hour drying process, the moisture content of the betel nut is reduced by 55% with a reduction rate of 7.85% / hour
FERMENTASI ENZIMATIS KOPI ROBUSTA (Coffea robusta) UNTUK PRODUKSI KOPI LUWAK KOPI SEHAT BERKELANJUTAN MELALUI PEMBELAJARAN JELAJAH ALAM SEKITAR (JAS)
Authors: Elvita Sari Desi
Published: March 2023

Abstrak: Pendekatan pembelajaran JAS adalah salah satu inovasi pendekatan pembelajaran Biologi dan merupakan kajian ilmu lain yang bercirikan memanfaatkan lingkungan sekitar dan simulasinya sebagai sumber belajar melalui kerja ilmiah, serta diikuti pelaksanaan belajar yang berpusat pada peserta didik. Kopi luwak merupakan kopi yang menggunakan biji kopi yang telah diproses dari system pencemaran hewan  luwak/musang. Biji kopi ini berada di dalam saluran pencernaan luwak selama 12 jam diyakini memiliki rasa yang berbeda setelah dimakan dan melewati saluran pencernaan luwak. Bioteknologi kopi luwak dapat dilakukan dengan proses meniru fermentasi enzimatis seperti yang terjadi dalam perut luwak. Jenis luwak bulan saat memakan biji kopi pada malam hari bisa menghasilkan 1 kg kopi luwak. dan jenis luwak pandan bisa menghasilkan 5 kg kopi luwak.
PENGARUH STRATEGI PEMBELAJARAN MODEL STD DAN TGT BERDASARKAN PENGELOMPOKAN KEMAMPUAN AKADEMIK TINGGI DAN RENDAH TERHADAP BIOLOGI KOGNITIF
Authors: Noviawan *Dwi , Karwono Karwono , Santoso Handoko
Published: March 2023

Riset di SMAN 5 Metro Tanggal 14 Juni - 30 September 2017. X1 (STAD dan TGT), X2 (Kemampuan Akademik Tinggi dan Rendah), Y (Biologi Kognitif). Eksperimen Faktorial 22. Sampel STAD 28, TGT 28 berdasarkan kemampuan akademik tinggi dan rendah. Pengambilan sampel acak bertingkat. Dokumentasi dan tes. Anova 2 jalur, uji t independent dan berpasangan.

Tujuan: 1) membedakan biologi kognitif  STAD dan TGT. Menunjukan hasil 0.689 > 0.05 tidak ada perbedaan dikeduanya. 2) membedakan biologi kognitif dari kemampuan tinggi dan rendahnya akademik. Hasilnya 0.891 > 0.05, artinya tidak berbeda. 3) berdasarkan akademik tinggi, digunakan model STAD dan TGT, membedakan biologi kognitifnya. Hasilnya Sig 0,854 (p > 0,05) artinya tidak berbeda. 4) berdasarkan kelompok akademik rendah, digunakan model pembelajaran STAD dan TGT, membedakan biologi kognitif.  Perhitungan SPSS nilainya Sig 0,833 (p > 0,05) berarti tidak berbeda. 5) mengetahui interaksi STAD dan TGT berdasarkan kemampuan akademik tinggi dan rendah terhadap biologi kognitif. Uji ANOVA 2 arah hasil X1 kepada Y Sig. 0.205 > 0.05 interaksi X2 kepada Y Sig 0.233 > 0.05 intraksinya tidak signifikan. Interaksi X1 dan X2 terhadap Y Sig. 0.443 > 0.05 interaksinya tidak signifikan.
ON THE ISSUE OF DEFINING THE CATEGORY OF DIMINUTIVENESS
Authors: Kim Khrystyna , Zhmayeva Natalya
Published: February 2023

The analysis of the phenomenon of diminutiveness and its derivatives presents significant difficulties for the researchers because the views of linguistics on the definition of category of diminutiveness due to the peculiarities of the semantic-functional reality of it are extremely contradictory and its definition is still not set, which determines the relevance of the paper.

The objective of the study is to establish the specificity of translation of the phenomenon of diminutiveness in poetic translation. To achieve this goal the continuous sampling method to research materials, the comparative method to compare the original and translated texts, the translation analysis method and the theoretical generalizations method were used.

It was determined that diminutiveness is a universal linguistic category that is expressed in the languages of the world using different levels of the language structure and realizes the meaning of a reduced size of an object, a reduced manifestation of an action or sign, and may also be accompanied by some expressive or evaluative-emotional patterns. As a result of a comparative analysis of the original poetry of Taras Shevchenko with its translations into English, it was found that the emotional component of diminutives is reproduced or neutralized in the translation. Techniques that reproduce the emotional component of diminutives include substitution and addition; techniques that neutralize are following: omission, selection of a direct translation equivalent, addition.
The Implementation of School-Based Management in Improving Quality of Education in Primary School
Authors: Hardiansyah Framz
Published: March 2023

Quality education is an absolute requirement to achieve national development goals; thus, education will produce superior and competitive human resources. Many government efforts improve the quality of education, among others, with regional autonomy or decentralization, which produces school-based management in the world of education. School-Based Management enables schools to be more independent through the granting of authority (autonomy), greater flexibility for schools in managing resources, and encouraging the participation of school members and the community to improve the quality of education. This research aims to determine how to implement school-based management to improve the quality of education in elementary schools. This research uses a qualitative descriptive method with data collection through interviews and observation. The subjects in this study were principals, teachers, school committees, community leaders, and stakeholders. This data analysis used data reduction, data presentation, and data validation (concluding). The results of the research findings indicate that the implementation of school-based management in improving the quality of education in elementary schools has been going well; the activeness of the school committee evidence this by providing suggestions/considerations, supporters, controllers, and mediators, the direct participation of parents in the planning and implementation of the program. In schools as well as management of curriculum and teaching programs, management of students, management of educators and education staff, and management of facilities and infrastructure are carried out well.
Studi Komparatif Penggunaan Platform Zoom dan Google Classroom sebagai Media Perkuliahan Daring
Authors: Putri Intan Cynara Valentina , Alti Rahmi Mudia , Asri Yoana Nurul , Wulandari Ike Yuni
Published: March 2023

In this study, a comparative study was conducted on the use of the Google Classroom and Zoom Meeting platforms during online lectures held at Nurtanio University. The object of research is students from various study programs at Nurtanio University, totaling 82 people. Data were obtained from questionnaires filled out by students on a google form with an ordinal scale. The questionnaire is divided into three components (lecture implementation, lecturer capabilities, and facilities and infrastructure) with a total of 15 statement items that compare perceptions of using Google Classroom and Zoom platforms. Overall, students gave a perception of the "good" category on the three assessment components with an average score for the Zoom and Google classroom platforms respectively 4.07 and 3.90 in the implementation of lectures, an average score of 4.06 and 3.96 for lecturer capabilities, and an average score an average of 3.84 and 3.76 for facilities and infrastructure. To find out whether there is a difference in student perceptions on the two platforms, a statistical test using SPSS is carried out, namely the Wilcoxon marked rank test. The results obtained are that there are differences in student perceptions on the use of the two lecture platforms, namely the perception of students using Google Classroom is better than using Zoom as evidenced by the Asymp score. Sig. (2-tailed) = 0.007 and Z value = 2.692.
Muatan HOTS pada Pembelajaran Tematik Materi IPA Kelas 5 Sekolah Dasar
Authors: Qiftiyah Maratul
Published: March 2023

This study aims to describe the content of higher order thinking skills in the fifth-grade science material on the theme of animal and human movement organs in terms of HOTS aspects. This type of research is a descriptive type of content analysis. The main source of this research is thematic books for grade V. The data were analyzed descriptively qualitatively and quantitatively. Analysis of the data of this research through three stages, namely data condensation, data display, and drawing conclusions or verification. The data collection technique in this study was reading and recording HOTS content in terms of its aspects. The results of this study found that the science material presents higher-order thinking skills at the C4-C6 level which refers to Bloom's revised taxonomy. Student thematic books also provide material to foster critical/creative thinking skills and reasoning abilities. HOTS aspects as critical and creative thinking dominate each sub-theme, while HOTS aspects as problem solving as well as the transfer of knowledge still need to be synchronized again.
Pengembangan Tes IPA Dua Tingkat Berbasis Permainan Jumanji Untuk Mengukur Pemahaman Konsep
Authors: Yuliatun Tutik , Uskenat Kristina , Jua Selestina Kostaria
Published: March 2023

This study aims to develop a two-level Natural Science (IPA) test instrument based on the jumanji game in measuring understanding of the concept of work and simple planes. The research method in this case is a quantitative method with a modification of the development model. The measurement instrument developed in this study is a two-level science test or a reasoned multiple choice test specifically for the business chapter and simple planes. This research instrument that has been developed was tested on 256 students of SMP Abu Bakar. The results of this study indicate that a measurement instrument has been produced in the form of a two-level science test based on the jumanji game which can measure students' understanding of concepts about business and simple and reliable machines that are valid and reliable. These results are evidenced by the validity and reliability of the two-level science test, which are 0.83 and 0.53 respectively. Meanwhile, the achievement of students' understanding of concepts related to business and simple machines is 51% which is in the high category. The students' conceptual understanding measured using the two-level science test is high because it exceeds the minimum criteria that have been determined.
Resistance to BRAF inhibitors in a patient with BRAF V600E-positive Langerhans cell histiocytosis
Authors: Lyudovskikh E. I. , Evseev D. A. , Osipova D. S. , Raykina E. V. , Kalinina I. I. , Baidildina D. D. , Maschan A. A. , Maschan M. A.
Published: March 2023

Here we report a clinical case of a patient with BRAF-positive Langerhans cell histiocytosis treated with combination therapy including trametinib. As the patient was undergoing long-term therapy with a BRAF inhibitor, his underlying disease reactivated. Hence it was suggested that the child might have become resistant to the treatment as a result of a subclonal mutation. It was concluded that this event undermined the efficacy of long-term therapy with BRAF inhibitors and highlighted the need for further study of possible molecular genetic mechanisms involved in the pathogenesis of Langerhans cell histiocytosis, as well as the need for the development of new treatment approaches. The patient's parents gave consent to the use of their child's data, including photographs, for research purposes and in publications.
Secondary Fisher–Evans syndrome in a child with activated PI(3)kd syndrome and lymphoma
Authors: Kuzminova Zh. A. , Fominykh V. V. , Kotskaya N. N. , Mitrakov K. V. , Moiseeva A. A. , Shvets O. A. , Livshits A. M. , Kurnikova M. A.
Published: March 2023

Evans syndrome, a combination of autoimmune hemolytic anemia and immune thrombocytopenia, is a rare disease in children. In childhood, it may turn out to be one of the first manifestations of a primary immunodeficiency or an immune dysregulation syndrome. Here we present a clinical case of a patient who was initially diagnosed with Evans syndrome and did not respond well to therapy. Based on the results of genetic testing, the child was then diagnosed with primary immunodeficiency, namely, activated PI(3)kd syndrome. During follow-up, the patient developed lymphoma and had to undergo radical treatment (allogeneic hematopoietic stem cell transplantation). The patient's parents gave consent to the use of their child's data, including photographs, for research purposes and in publications.
Flow cytometry in acute leukemia diagnostics. Guidelines of Russian-Belarusian multicenter group for pediatric leukemia studies
Authors: Popov A. M. , Verzhbitskaya T. Yu. , Movchan L. V. , Demina I. A. , Mikhailova E. V. , Semchenkova A. A. , Permikin Zh. V. , Shman T. V. , Karachunskiy A. I. , Novichkova G. A.
Published: March 2023

Flow cytometry is one of the key technologies for acute leukemia (AL) diagnostics. Nevertheless, lack of technological standards hampers implementation of immunophenotyping data in treatment protocols. Earlier our group published the acute lymphoblastic leukemia diagnostic standards. In this paper, we present the updated guidelines for initial immunophenotyping of ALs. This wellharmonized approach includes recommendations for monoclonal antibodies choice, sample preparation, cytometer setup, data analysis and interpretation as well as for the report writing. These guidelines allows application of diagnostic flow cytometric studies in all types of AL.
The use of inotuzumab ozogamicin in children with relapsed/refractory B-lineage acute lymphoblastic leukemia
Authors: Evstratov D. A. , Shutova A. D. , Dyakonova Yu. Yu. , Radygina S. A. , Abugova Yu. G. , Anderzhanova L. Kh. , Vavilova L. A. , Litvinov D. V. , Novichkova G. A. , Popov A. M. , Fominykh V. V. , Khachatryan L. A. , Shelikhova L. N. , Myakova N. V.
Published: March 2023

Today, treatment results for acute lymphoblastic leukemia (ALL) look encouraging, yet 10–15% patients still end up relapsing. The success of relapse treatment is directly dependent on whether or not a tumor clone has been completely eradicated before hematopoietic stem cell transplantation (HSCT). Immunotherapy made it possible to achieve minimal residual disease (MRD) – negative remission even in refractory patients. One example of such immunotherapeutic agents is inotuzumab ozogamicin (InO), an anti-CD22 monoclonal antibody conjugated to the cytotoxic agent calicheamicin. We included 17 patients under the age of 18 with relapsed or refractory precursor B-cell ALL (pre-B ALL) who had been treated with InO at the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of Russia from 01.10.2016 to 01.09.2022. The study was approved by the Independent Ethics Committee and the Scientific Council of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology. The efficacy of the therapy was assessed based on the patients’ morphological response, MRD negativity and overall survival. Treatment toxicity was assessed according to CTCAE 5.0 (Common Terminology Criteria for Adverse Events). Statistical analysis was performed using the XLSTAT 2016 software. The majority of the patients (75%) responded to the therapy. MRD negativity was achieved in 41.2% of the study patients. The one-year overall survival rate was 40.3% (95% confidence interval 14.8–65.7). The treatment was well tolerated but 33% of the patients treated with standard-dose InO and subsequent HSCT developed veno-occlusive disease/sinusoidal obstruction syndrome. In our study, we demonstrated the high efficacy of InO both when used as a rescue therapy in patients with relapsed/refractory pre-B ALL and as a bridging therapy in patients before HSCT.