bluuebunny/crossref_metadata_2025 huggingface dataset:
lncRNA-mRNA Co-Expression and Regulation Analysis in Lung Fibroblasts from Idiopathic Pulmonary Fibrosis
Authors: López-Martínez Armando , Santos-Álvarez Jovito Cesar , Velázquez-Enríquez Juan Manuel , Ramírez-Hernández Alma Aurora , Vásquez-Garzón Verónica Rocío , Baltierrez-Hoyos Rafael
Published: April 2024

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease marked by abnormal accumulation of extracellular matrix (ECM) due to dysregulated expression of various RNAs in pulmonary fibroblasts. This study utilized RNA-seq data meta-analysis to explore the regulatory network of hub long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) in IPF fibroblasts. The meta-analysis unveiled 584 differentially expressed mRNAs (DEmRNA) and 75 differentially expressed lncRNAs (DElncRNA) in lung fibroblasts from IPF. Among these, BCL6, EFNB1, EPHB2, FOXO1, FOXO3, GNAI1, IRF4, PIK3R1, and RXRA were identified as hub mRNAs, while AC008708.1, AC091806.1, AL442071.1, FAM111A-DT, and LINC01989 were designated as hub lncRNAs. Functional characterization revealed involvement in TGF-β, PI3K, FOXO, and MAPK signaling pathways. Additionally, this study identified regulatory interactions between sequences of hub mRNAs and lncRNAs. In summary, the findings suggest that AC008708.1, AC091806.1, FAM111A-DT, LINC01989, and AL442071.1 lncRNAs can regulate BCL6, EFNB1, EPHB2, FOXO1, FOXO3, GNAI1, IRF4, PIK3R1, and RXRA mRNAs in fibroblasts bearing IPF and contribute to fibrosis by modulating crucial signaling pathways such as FoxO signaling, chemical carcinogenesis, longevity regulatory pathways, non-small cell lung cancer, and AMPK signaling pathways.
Data, Signal and Image Processing and Applications in Sensors II
Authors: Reis Manuel J. C. S.
Published: April 2024

A vast and ever-growing amount of data in various domains and modalities is readily available, being the rapid advance of sensor technology one of its main contributor [...]
Kinematic and Joint Compliance Modeling Method to Improve Position Accuracy of a Robotic Vision System
Authors: Ye Fan , Jia Guangpeng , Wang Yukun , Chen Xiaobo , Xi Juntong
Published: April 2024

In the field of robotic automation, achieving high position accuracy in robotic vision systems (RVSs) is a pivotal challenge that directly impacts the efficiency and effectiveness of industrial applications. This study introduces a comprehensive modeling approach that integrates kinematic and joint compliance factors to significantly enhance the position accuracy of a system. In the first place, we develop a unified kinematic model that effectively reduces the complexity and error accumulation associated with the calibration of robotic systems. At the heart of our approach is the formulation of a joint compliance model that meticulously accounts for the intricacies of the joint connector, the external load, and the self-weight of robotic links. By employing a novel 3D rotary laser sensor for precise error measurement and model calibration, our method offers a streamlined and efficient solution for the accurate integration of vision systems into robotic operations. The efficacy of our proposed models is validated through experiments conducted on a FANUC LR Mate 200iD robot, showcasing notable improvements in the position accuracy of robotic vision system. Our findings contribute a framework for the calibration and error compensation of RVS, holding significant potential for advancements in automated tasks requiring high precision.
Study of the Prediction of Vibrations in Soft Soil Foundations Based on Field Tests
Authors: Lin Jiaxin , Zhang Nan , Zhang Yunshi
Published: April 2024

To explore the prediction of vibrations in soft soil foundations, in light of the construction of laboratories with microvibration requirements on soft soil foundations which are subject to the limitations of urban land planning, field testing was conducted, and the soil surface vibration responses were recorded at different distances from a road under various highway traffic loads. By analyzing the data which summarize the characteristics of soft soil foundations, it is clarified that the vibration response of soft soil foundations mainly occurs at low frequencies, and the vibration response under road traffic loads is prone to resonance at the natural frequency of soft soil foundations. Subsequently, a new vibration prediction method based on the vibration transmission ratio is proposed, and its effectiveness and accuracy based on transmissibility are verified. This research study provides a reference for laboratories constructed on soft soil and for surrounding traffic planning.
Modular and Cost-Effective Computed Tomography Design
Authors: Bieberle André , Hoffmann Rainer , Döß Alexander , Schleicher Eckhard , Hampel Uwe
Published: April 2024

We present a modular and cost-effective gamma ray computed tomography system for multiphase flow investigations in industrial apparatuses. It mainly comprises a 137Cs isotopic source and an in-house-assembled detector arc, with a total of 16 scintillation detectors, offering a quantum efficiency of approximately 75% and an active area of 10 × 10 mm2 each. The detectors are operated in pulse mode to exclude scattered gamma photons from counting by using a dual-energy discrimination stage. Flexible application of the computed tomography system, i.e., for various object sizes and densities, is provided by an elaborated detector arc design, in combination with a scanning procedure that allows for simultaneous parallel beam projection acquisition. This allows the scan time to be scaled down with the number of individual detectors. Eventually, the developed scanner successfully upgrades the existing tomography setup in the industry. Here, single pencil beam gamma ray computed tomography is already used to study hydraulics in gas–liquid contactors, with inner diameters of up to 440 mm. We demonstrate the functionality of the new system for radiographic and computed tomographic scans of DN110 and DN440 columns that are operated at varying iso-hexane/nitrogen liquid–gas flow rates.
Design, Synthesis and Antimicrobial Potential of Conjugated Metallopeptides Targeting DNA
Authors: Moreno-Ramirez Maria Camila , Arias-Bravo Adriana Stefania , Aragón-Muriel Alberto , Godoy César Alonso , Liscano Yamil , Garzón Jose Oñate , Polo-Cerón Dorian
Published: April 2024

Antimicrobial resistance threatens the effective prevention and treatment of an increasingly broad spectrum of infections caused by pathogenic microorganisms. This pressing challenge has intensified the search for alternative antibiotics with new pharmacological properties. Due to the chemical synergy between the biological activity of antimicrobial peptides (AMPs) and the different modes of action, catalytic properties, and redox chemistry of metal complexes, metallopeptides have emerged in recent years as an alternative to conventional antibiotics. In the present investigation, peptide ligands conjugated with 5-carboxy-1,10-phenanthroline (Phen) were prepared by solid-phase peptide synthesis (SPPS), and the corresponding copper(II) metallopeptides, Cu-PhenKG and Cu-PhenRG (where K = lysine, R = arginine, and G = glycine), were synthesized and characterized. The antimicrobial activities of these compounds toward Gram-positive and Gram-negative bacteria, evaluated by the broth microdilution technique, indicate that the metal center in the metallopeptides increases the antimicrobial activity of the complexes against the conjugated peptide ligands. Minimum inhibitory concentration (MIC) values of 0.5 μg/mL for S. aureus with the Cu-PhenKG complex and 0.63 μg/mL for S. typhimurium with the Cu-PhenRG complex were obtained. The MIC values found for the conjugated peptides in all microorganisms tested were greater than 1.5 μg/mL. The interactions of the conjugated peptides and their metallopeptides with plasmid DNA were evaluated by agarose gel electrophoresis. Alterations on the replication machinery were also studied by polymerase chain reaction (PCR). The results indicate that the complexes interact efficiently with pBR322 DNA from E. coli, delaying the band shift. Furthermore, the resulting DNA–metallopeptide complex is not a useful template DNA because it inhibits PCR, since no PCR product was detected. Finally, molecular dynamics and molecular docking simulations were performed to better understand the interactions of the obtained compounds with DNA. The Cu-PhenRG complex shows a significantly higher number of polar interactions with DNA, suggesting a higher binding affinity with the biopolymer.
Protocol for the RoboSling Trial: A Randomised Study Assessing Urinary Continence Following Robotic Radical Prostatectomy with or without an Intraoperative Retropubic Vascularised Fascial Sling (RoboSling)
Authors: Virk Amandeep , Treacy Patrick-Julien , Zhong Wenjie , Jackson Stuart Robert , Ahmadi Nariman , Jeffery Nicola Nadia , Chan Lewis , Sved Paul , Vasilaras Arthur , Thanigasalam Ruban , Leslie Scott
Published: April 2024

Objectives: To determine if early (three months) and late (one year) post-operative continence is improved by performing a novel retropubic vascularised fascial sling (RoboSling) procedure concurrently with robot-assisted radical prostatectomy in men undergoing treatment for localised prostate cancer. To additionally assess surgical outcomes, quality of life and health economic outcomes in patients undergoing the novel RoboSling technique. Methods: This study aims to recruit 120 consecutive patients with clinically localised prostate cancer who have chosen to undergo robot-assisted radical prostatectomy in the Sydney Local Health District, Australia. A prospective assessment of early and late post-operative continence following robot-assisted radical prostatectomy with and without a RoboSling procedure will be performed in a two-group, 1:1, parallel, randomized controlled trial. Four surgeons will take part in the study, all of whom are beyond their learning curve. Patients will be blinded as to whether the RoboSling procedure is performed for them, as will be the research officers collecting the post-operative data on urinary function. Trial Registration: ACTRN12618002058257. Results: The trial is currently underway. Conclusions: The RoboSling technique is unique in that the sling is vascularised and has a broad surface area compared to previously described slings in the literature. If a clinically significant improvement in post-operative continence is established with the RoboSling, then, we can in turn expect improvements in quality of life for men undergoing this technique with radical prostatectomy.
Research on Obstacle Avoidance Trajectory Planning for Autonomous Vehicles on Structured Roads
Authors: Li Yunlong , Li Gang , Peng Kang
Published: April 2024

This paper focuses on the obstacle avoidance trajectory planning problem for autonomous vehicles on structured roads. The objective is to design a trajectory planning algorithm that can ensure vehicle safety and comfort and satisfy the rationality of traffic regulations. This paper proposes a path and speed decoupled planning method for non-split vehicle trajectory planning on structured roads. Firstly, the path planning layer adopts the improved artificial potential field method. The obstacle-repulsive potential field, gravitational potential field, and fitting method of the traditional artificial potential field are improved. Secondly, the speed planning aspect is performed in the Frenet coordinate system. Speed planning is accomplished based on S-T graph construction and solving convex optimization problems. Finally, simulation and experimental verification are performed. The results show that the method proposed in this paper can significantly improve the safety and comfortable riding of the vehicle.
Uso de impressão 3D para fabricação de peças com encaixe para robôs móveis
Authors: Cantú Cauanan , Rubin Ricardo Soares
Published: April 2024

A Olimpíada Brasileira de Robótica (OBR) visa incentivar jovens do ensino fundamental, médio e técnico a explorar carreiras em ciência e tecnologia, enquanto promove inovação no ensino. Durante essas competições, robôs móveis montados e programados pelos alunos são utilizados para superar desafios, premiando as equipes mais destacadas. Buscando desenvolver um robô autônomo adaptável aos testes, introduzimos um dispositivo modular de encaixe para estimular a criatividade e o desenvolvimento técnico dos jovens. No entanto, desafios como rebarbas e desgaste do material afetam a precisão dos encaixes, exigindo atenção aos parâmetros de impressão 3D. Este estudo visa avaliar como temperatura, velocidade e expansão horizontal influenciam a qualidade das peças, fornecendo insights valiosos para aprimorar os processos de prototipagem e montagem de equipamentos robóticos, impulsionando a evolução da manufatura aditiva.
Configuration Design Method of Mega Constellation for Low Earth Orbit Observation
Authors: Yang Yuheng , Wu Xiande , Li Jiamin , Zang Jie , Lu Jianchun , Zgeib Ralf
Published: April 2024

The configuration optimization design of Low Earth Orbit observation mega constellation in complex space environment is a nonlinear problem that is difficult to solve analytically. In this paper, a constellation design method is proposed, considering satellite imaging width, formation flying of subgroup satellites, and global uniform coverage by payloads. Firstly, a configuration of satellites with the same subsatellite trajectory is proposed, and its orbital analytical expression under J2 perturbation is provided. Then, the relative motion feature points are extracted near the orbit of each satellite, and a group of uniform natural accompanying satellites are set to corresponding points. Afterwards, the orbit parameters of satellite and its companions are set as initial values, and the precise orbits under the High Precision Orbit Propagator model are solved in the neighborhood by using the Nondominated Sort Particle Swarm Optimization algorithm. Finally, the correctness of the configuration design method is verified by numerical simulation.
Preferred Learning Methods among First-year Medical Students: A Cross-Sectional Descriptive Study
Authors: Dehghani Gholamali
Published: April 2024

Background. Understanding how learners process and organize new experiences and acquire information is one of the critical factors affecting the effective teaching and learning. Therefore, the objective of this study was to investigate the perception and processing of information by first-year medical students. Methods. In this cross-sectional study, the convenience sampling method was adopted to select and investigate 180 first-year medical students of Tabriz University of Medical Sciences in the 2nd semester of the academic year 2022-2023. Data were collected using a questionnaire consisting of two parts – demographic factors and Kolb's learning styles inventory (LSI). The collected data were analyzed using SPSS-25 and applying descriptive statistics, Chi-square (χ2), t-test, and one-way analysis of variance (ANOVA). Results. According to the results, students preferred the learning method of Abstract Conceptualization (33.89 ± 7.44), followed by active experimentation (29.85 ± 9.77), reflective observation (29.77 ± 8.64), and concrete experience (26.49 ± 9.32). The predominant learning styles adopted by the students were assimilating (38.3%), converging (32.2%), diverging (22.8%), and accommodating (6.7%). No significant differences were found between students' preferred learning methods and demographic variables (i.e., gender, marital status, age, and residential status) (P>0.05). Conclusion. It was concluded that the dominant learning style was not an exclusive factor in predicting educational achievement. It was recommended that the teachers should take their students' learning preferences into account when designing learning opportunities.
Correlation of 2,4-DDT with CDH1 Gene Promoter Methylation in Gastric Cancer
Authors: Ashrafi Mohammad Reza , Asadikaram Gholamreza , Darvish-Moghaddam Sodaif , Abolhassani Moslem , Iranpour Maryam , Sepehri Zahra
Published: April 2024

Background: Methylation alterations of tumor suppressor gene promoters are important epigenetic changes in gastric cancer. CDH1 encodes a protein (cadherin1) with essential roles in cell-cell adhesion. In this study, the association of organochlorine pesticide (OCP) serum levels with the methylation profile of this gene was investigated in gastric cancer, intestinal metaplasia (IM), and functional dyspepsia (FD) patients. Methods: Gastric cancer (n=34), IM (n=8), and FD (n=48) patient serums were analyzed for the determination of OCP levels by gas chromatography. The methylation status of the CDH1 gene promoter was examined by the methylation-specific PCR (MSP) method. Immunohistochemistry (IHC) was used to confirm the reduced protein expression of this gene in methylated samples. Results: Our findings revealed significant hypermethylation of the CDH1 gene promoter and its reduced expression in gastric cancer patients compared with IM and FD patients. Furthermore, there was a significant association between CDH1 promoter hypermethylation and 2,4-DDT (OR=1.183; 95% CI=1.001–1.398; P=0.048) serum levels in gastric cancer patients. Conclusion: Our results suggest an association between 2,4-DDT OCP levels in gastric cancer patient serums with CDH1 gene promoter hypermethylation. Additionally, this gene promoter’s methylation may play a role in the progression of pre-cancerous IM towards gastric cancer.
Development and Validation of a Simple Equation to Fat Mass and Percentage of Body Fat in Children and Adolescents
Authors: Asadi Maryam , Zare Javid Ahmad , Kazemi Parvaneh , Sharifat Morteza , Samadani Mahsa , Bavi Behbahani Hossein
Published: April 2024

Background: This study aimed to develop and validate a simple equation to fat mass (FM) and percentage of body fat (PBF) in children and adolescents. Methods: Participants consisted of 404 children and adolescents (176 males and 228 females, 5-18 years old) randomly divided into Derivation (n=279) and Validation (n=125) groups. FM and PBF were measured by a bioelectrical impedance analyzer. Based on demographic variables retrieved from the derivation group, 10 FM and 10 PBF predictive equations were developed using multiple regression. Finally, the most accurate model (using the coefficient of determination - R2 ) was chosen and validated on the validation group. Results: The best FM and PBF equations, which were derived from demographic characteristics, were: FM (kg)=Weight (kg) x 0.15+BMI x 1.53+Sex x 3.40 – Age (years) x 0.37 – 26.20; where sex=1 for male and 0 for female. R=0.97, R2=0.94, standard error of the estimate (SEE)=3.74 kg. PBF (kg)=0.31 x Height (cm) - Weight (kg) x 0.59+BMI x 2.98+Sex x 6.17 – Age (years) x 0.76 – 52.84; where sex=1 for male and 0 for female. R=0.90, R2=0.82, SEE=4.88 kg. Conclusion: Our predictive equations accurately predicted FM and PBF using simple parameters (height, weight, BMI, sex, and age) in children and adolescents.
Characterization and Structural Analysis of the Human Papilloma Virus L1 Protein in Iran
Authors: Hasanshahi Zahra , Dehghani Behzad , Hashempour Ava , Alamdari Elnaz
Published: April 2024

Background: Human papillomavirus (HPV) is a small, non-enveloped DNA virus related to human cervical cancer. The genome is maintained within the basal epithelium where the primary infection is latent. During the late phase of infection, the capsid proteins (L1 and L2) are expressed to encapsidate the viral genome, generating the infectious virion particles required for HPV propagation. HPV genome encodes six proteins, namely E6 oncoprotein, E7 oncoprotein, E1 replication protein, E2 regulatory protein, L1 major capsid protein, and L2 minor capsid protein. L1 is the principal part of the current vaccines, and any changes in this region can decrease vaccine efficiency. The aim of this research was to conduct a comparative analysis among Iranian L1 protein sequences with reference sequences to determine the possible substation in this region and to find the physicochemical and structural properties of L1 by using bioinformatics tools to provide comprehensive comprehension of the HPV L1 protein. Methods: Thirteen Iranian PV sequences of the L1 protein and reference sequences were selected and obtained from the NCBI data bank. CLC Sequence Viewer software was used to translate the alignment. PrediSi and Phobius were employed to predict the signal peptide. The secondary and tertiary structures and structure validations of all sequences were analyzed by Qmean, (PS)2-v2, Phyre2server, Discovery Studio, and I-TASSER. Results: The findings showed that L1 is highly conserved, and only two mutations were found in this region. No signal peptide was described, and this region’s main part included a random coil. The tertiary structure was mapped using different software, and five distinct loops were found. Conclusion: This study is the first report that investigated the changes in the L1 protein of Iranian patients and provided helpful comprehension of the L1 properties vital for cloning and producing the new generation of virus-like particle (VLP) vaccines. Furthermore, the structural analysis showed several loops that had an indispensable role in antibody binding and the prevention of HPV infections.
Vitamin D and Calcium Deficiency and its Relationship with Cardiac Function in Patients with Beta-Thalassemia
Authors: Ahmadipour Maryam , Naghibzadeh-Tahami Ahamd , Mirzaie Koroush , Maleki Elham
Published: April 2024

Background: Heart disease is the leading cause of mortality and morbidity in patients with beta-thalassemia. Vitamin D and calcium deficiency are common in these patients. We studied and compared vitamin D and calcium levels and other parameters with echocardiographic findings in patients with beta-thalassemia. Methods: A cross-sectional study on patients with transfusion-dependent thalassemia was conducted. One hundred sixty-nine patients with transfusion-dependent thalassemia were enrolled. Ejection fraction, valvular insufficiency, and aortic diameter were determined. The aortic diameter of patients was measured using the Mindray DC60 echo model. All of these patients were tested for levels of vitamin D, calcium (Ca), parathyroid hormone (PTH), alkaline phosphatase (ALP), platelet (PLT), and ferritin. Finally, the effect of these factors on aortic root (AR), aortic valve area (AVA), and ejection fraction (EF) was evaluated. One-way ANOVA was used to compare quantitative variables, and a chi-square test with a 95% confidence level was used to estimate relationships and compare ratios in groups. Results: A statistically significant relationship existed between vitamin D deficiency and serum Ca (P value=0.009). Our results showed that EF also increased with the increase in vitamin D levels, and the probability that the AR would have a normal size increased. Furthermore, abnormal PTH and PLT levels caused a decrease in EF. Conclusion: This study showed an association between vitamin D deficiency and cardiac function in patients with transfusion-dependent thalassemia. Vitamin D can be considered a supplement for thalassemia patients.
Evaluation of the Relationship Between T2*CMR and Cardiac Depolarization and Repolarization Parameters in Beta-Thalassemia Patients
Authors: Ghandi Yazdan , Ghahremani Bita , Eghbali Aziz , Yousefichaijan Parsa , Bahrami Masoud
Published: April 2024

Background: Cardiac iron overload causes severe cardiac complications and is a leading cause of death in beta-thalassemia major (B-TM) patients. T2-weighted cardiovascular magnetic resonance (T2*CMR) can detect preclinical cardiac iron overload. We evaluated the ability of 12-lead electrocardiographic atrial and ventricular depolarization and repolarization parameters to predict cardiac iron loading in TM. Methods: This cross-sectional study was conducted on patients with beta-thalassemia major; all participants underwent a standard 12-lead electrocardiogram during a single study visit, and the depolarization and repolarization parameters of ECG were measured and compared with the cardiac iron level detected by T2*CMR, with a detectable cardiac iron cutoff of T2* less than 20 ms. Results: A total of 26 patients (mean age of 26.19 years, 34.62% male) were included. Mean T2*CMR values were 21.53 ms (46.15%<20 ms, 53.85%≥20 ms). Among ECG parameters, only Pwd, QTc, and QTcd (P values 0.026, 0.030, and 0.006, respectively) were significantly prolonged in patients with T2*<20 ms compared to patients with T2*≥20 ms. There was a statistically negative correlation between T2*CMR, Pwd, and QTcd (P values 0.028 and 0.021, respectively). Moreover, no correlation was found between Tp-e, Tp-e d, JTc, JTcd, Tp-e/QT, Tp-e/JT, Tp-e/JTc, and T2* values. Conclusion: Pwd and QTcd can be used as alternatives to T2*CMR to predict cardiac iron load levels in patients with beta-thalassemia major.
Hardware complex for measuring the power of UHF signals
Authors: A.Yu. Zymoglyad , A.I. Guda , S. Klishch
Published: April 2024

The article describes the scheme and construction of a hardware device for measuring the power of UHF radio signals. The developed hardware device can measure the signal strength in the frequency range of 0.8 – 6 GHz. For the research of receiving and transmitting devices, as well as antennas in the UHF bands, expensive equipment is required. This is often what stops research with this wave range. However, if we single out the 0.8-6 GHz range, it is possible to make some devices for evaluating the signal power based on modern microcircuit engineering solutions. Of course, the complex that will be considered in this work will not replace a full-fledged spectrum analyzer or other high-frequency measuring device. However, a qualitative assessment will be possible, it will be possible to assess the changed signal or which antenna transmits the signal more. This indicates that the development of such a complex is an urgent task. A hardware complex has been developed, which consists of 2 units, the UHF signal amplifier on the QPL9547 microcircuit and the demodulating logarithmic amplifier on the AD8319. The results of the research, which were presented in the table. 1 show how the UHF signal strength meter responded to a series of input signals of varying strength. This complex can be used in laboratory studies of the output power of transmitting devices, for qualitative evaluation of antennas or antenna comparisons. Due to the am-plifier at the input, it is possible to study the signal power up to −80 dBm. The described complex also has a fairly moderate price, compared to industrial analogues.
Prototyping of control units for systems with industrial controllers
Authors: O. Poliakov , B. Zhurakovskyi
Published: April 2024

Reducing the design time of the system control unit remains an urgent task for the developers of these systems. The problem of designing control units based on program-mable logic controllers (PLCs) is their high cost and, as a rule, unavailability at the initial design stage. The aim of the research is to reduce the time and cost of designing the sys-tem by creating prototypes of control units with the software implementation of the con-trol algorithms of the languages of the IEC 61131-3 standard and the execution of pro-grams in the Arduino board. The research method consists in the decomposition of pro-ject models of operating and control automata of the control device and their implemen-tation in the OpenPLC application environment in the form of program organization components (POU) in Ladder Diagram, Function Block Diagram and Sequential Function Chart languages. The result of the study is a method of creating typical POU operating and control automata of the control system, which are executed in the Arduino board. An example of the application of the proposed methodology for the design of a prototype of the object's temperature control system, which can be useful for teaching PLC program-ming, is given. The developed prototype was tested using a logical PLC and a physical prototype, which confirmed their functional compliance with the original and a reduction in the cost of the equipment by at least an order of magnitude.
Methodology of step-by-step design of investment project portfolio
Authors: Artem Basko , Nina Еrshova
Published: April 2024

Forming a portfolio of projects is a key task of managing an organization. Analysis of the life cycle of the project portfolio shows that the phase of project portfolio selection is the most important. Until now, the problems of this phase have not found an optimal solution. Therefore, the authors propose a methodology for the step-by-step design of a portfolio of investment projects. The first stage is the formation of a portfolio of projects based on mathematical programming and modeling methods. The second stage is the evaluation of the effectiveness of the selected projects by the method of analysis of hierar-chies. The third stage is the distribution of investors' funds between the projects of the project portfolio on the basis of playing with nature. The evaluation of the effectiveness of three projects was carried out using the method of hierarchy analysis. The criteria are indicators of efficiency: indicator of scientific and technical efficiency, economic indica-tor, social indicator and indicator of ensuring information security. Each criterion has 4 subcriteria. The results of the calculation determined the following efficiency of the pro-jects: the first (44.36%), the second (22.95%) and the third (32.70%). Therefore, it is nec-essary to distribute resources between projects in such proportions. It has been proven that the design of a portfolio of investment projects is a complex process, and it must be carried out in stages, using modern mathematical decision-making methods and tech-nologies for each of them.
Research of the Amazon Lex V2 natural language recognition system
Authors: V.O. Nosov , K.Yu. Ostrovska
Published: April 2024

In modern realities, systems with text and voice recognition are increasingly used, because the process of interaction with a person is increasingly automated. Human speech recognition technology is fundamental to the development of artificial intelligence. Systems that are built on this technology have the ability to solve a fairly large number of tasks related to data analysis, information search, and fulfillment of user requests. Voice assistants, smart home systems (such as Amazon Alexa or Google Assistant) are popular and quite common solutions for systems with NLP (Natural Language Processing). The study of this technology and the analysis of its integration in cloud environments provides an opportunity to independently use its features as automated assistants, or, for example, as part of an already existing intelligent system. The NLP core of the Amazon Lex V2 service provides an opportunity to deploy a self-configured chatbot on a given topic, therefore, from the point of view of development and research, it attracts the attention of developers and analysts. But, before that, many questions arise regarding its possibilities and limitations, which the integrator of this service will face.
Influence of existing rule processing optimizations on the performance of the snort 3 network intrusion detection system
Authors: V.S. Gorbatov , A.O. Zhurba
Published: April 2024

Network intrusion detection systems (NIDS) are a key component of cybersecurity, working to warn, detect, and respond to potential network threats. They analyze network traffic to detect anomalous or malicious activity such as breach attempts, viruses, use of software exploits, and more. Intrusion detection systems should perform packet inspec-tion at or near cable speed to be highly effective. The speed of intrusion detection systems is critical because it allows timely mitigation of potential cyber threats, ensuring uninter-rupted operation of business processes. One of the most common and recognized tools in the field of NIDS is the intrusion detection system Snort, which has already proven itself as a powerful means of protecting networks. Snort 3 is an updated version of this system, and has multithreading, increased speed compared to Snort, greater modularity and other advantages[2], so we will concen-trate on it in the context of this article. The task of optimizing the operation of NIDS is very acute. Due to the variability and multifunctionality of existing systems, there is a wide field for analyzing and improv-ing the efficiency of NIDS both for specific tasks and for tasks of a broad profile. So many works look at the performance of Snort 3 compared to other intrusion detection sys-tems[3] in different types of infrastructures, which will help the user to find the best op-tion for himself. The purpose of the study is to consider the three main rule processing optimization algorithms used in the Snort 3 system, namely Fast Pattern, port-based and protocol-based clustering. For them, the basic implementation, modifications of the source code, which are necessary to disable the algorithm, as well as the impact of the algorithm on the overall speed of the system, will be described. Some results have shown a slight performance improvement when the optimization algorithms are disabled, this is on configurations with a small number of rules. In most cases, a clear drop in performance of 10% or more is noticeable. The biggest deteriora-tion in performance occurs when Fast Pattern operations are disabled, without this algo-rithm the deterioration can reach 20 times.
Ecological and geochemical features of mercury accumulation in coniferous wood in the Altai Region
Authors: Lyapina Elena
Published: April 2024

Determination of the level of mercury load on the territory of the Altai Region was carried out using the dendrogeochemistry method. The study area is located in the north-west of the Altai Region within the Kulunda Plain. The studied trees were represented by Scots pine (Pinus sylvestris L.) and siberian larch (Larix sibirica L.). The average concentrations of mercury in the cores of all studied trees vary in a wide range: 2-493 ng/g. The maximum average contents are observed at the extreme sampling points: south and north - on the periphery of the sampling area. The research covers the time interval: 1952-2018. There is a period with a significant increase in the average mercury content in tree rings from 1957 to 1990, after which there was a sharp decrease in the concentration of the element. Numerous extremes are observed in the interval: 1978-1988. Calculations of geoecological parameters of mercury load in the study area showed an excess of mercury content in tree rings above background values, as well as the noosphere clarke, average for terrestrial plants and living matter. Almost all studied trees are characterized by a similar pattern of mercury accumulation in trees. A connection was revealed in the accumulation of mercury in wood cores of coniferous trees with the substrate, as well as pine needles. Mercury accumulated by pine needles affects the concentration of the element in the pine litter, and thereby the level of pollutant in the substrate. A high proportion of bioavailable forms of mercury in dark chestnut soils and southern chernozems. When accumulating an element, it is important to take into account the amount and duration of precipitation both during the year and during the growing season.
Climate sensitivity alteration of the Middle Sikhote-Alin main conifer species
Authors: Rubleva Marina , Vozmishcheva Anna , Bondarchuk Svetlana
Published: April 2024

Climate of the South of the Russian Far East is exposed to changes that are proved by meteorological data. Trees are a reliable indirect indicator of Global climate change, which has been confirmed in a number of published works around the world. The multi-species, multi-level, structurally complex forests of the Middle Sikhote-Alin are distinguished by their complex dynamic processes and the absence of direct anthropogenic influence. The trees’ response to climatic factors with which there is a significant reliable relationship (precipitation, temperature) is observed in this work. Cores were selected using standard dendrochronological approaches. The “treeclim” package of R software was used for dendroclimatic analysis. Graphs were obtained for the dynamics of climatic sensitivity of the main conifer species of the Middle Sikhote-Alin (Pinus koraiensis Siebold & Zucc., Abies nephrolepis (Trautv.) Maxim., Picea jezoensis (Siebold & Zucc.) Carriere, Larix gmelinii (Rupr.) Kuzen.) for a period of 78 years. The stability of dendroclimatic relationships in time was examined and the periods of its alteration were noted. The most climate-sensitive species among those studied were Gmelin larch and Ayan spruce. They are most vulnerable to droughts and their habitats may shift northward with further increases in growing season mean monthly air temperatures.
E-PARTICIPATION IN URBAN PLANNING: ISTANBUL SENIN APPLICATION
Authors: Şahin Elifsu
Published: April 2024

In parallel with the developments in information and communication technologies, traditional participation in urban planning processes is gradually evolving into e- participation applications. For the effective use of e-participation applications, it is important to evaluate the effectiveness and quality of the applications in terms of participation mechanisms, design, interaction, structure, transparency, and security of processes. The aim of the study is to examine Istanbul Senin application in terms of e-participation, to investigate the use of this application by the citizens and to offer suggestions for its improvement.The study seeks answers to the questions of what the positive and negative aspects of the Istanbul Senin application are in the context of e-participation and how it is used by citizens. The study was designed in two stages. First, Istanbul Senin application was analyzed in line with the criteria for evaluation of e-participation platforms. Second, a survey was conducted to examine the use of this application. The sample group was determined on a voluntary basis and a sample of 100 participants was determined within a reasonable margin of error (10%), taking time and cost into account. Accordingly, issues such as informing and raising awareness of the citizens about the importance of participatory processes, increasing the familiarity of the application, improving the design and increasing the ease of use, improving the way of interaction have been emphasized for the Istanbul Senin application.
Methods for Designing Devices and Systems of Medical Electronics
Authors: Bandaryk V. M. , Vashkevich M. I. , Davydov M. V. , Davydova N. S. , Zelmanski O. B. , Kamlach P. V. , Mezhennaya M. M. , Osipov A. N.
Published: April 2024

A brief overview of the results of work in the ﬁeld of “Devices, systems and technologies for medical purposes”, obtained with the direct participation of the authors of the article, is given. The results of the development and research in the ﬁeld of modeling the eﬀects of physical factors on the human body and digital processing of biomedical signals are presented. The principal aspects of the original systems of long-term monitoring of the human condition and control of the musculoskeletal system are presented.
Research and Development in the Field of Creating Materials, Technologies and Safety Equipment
Authors: Bogush V. A. , Lynkou L. V. , Nasonova N. V. , Prischepa S. L. , Belousova E. S. , Boiprav O. V. , Davydau H. V. , Papou V. A. , Patapovich A. V. , Pukhir H. A.
Published: April 2024

Technologies for the manufacture of microwave electromagnetic shields based on powdered carbon, foil and composite multilayer materials are presented. Technological methods for their manufacture and shielding properties are described, and the main mechanisms leading to increased shielding properties are considered depending on the manufacturing technology, composition and alternation of composite layers. It is shown that the values of the reﬂection coeﬃcient of electromagnetic radiation in the frequency range 2–17 GHz for the shields considered reach a value of (–20) dB. Microwave absorbers with a reﬂection characteristic lower than (–10.0) dB (down to (–52.0) dB) in the frequency band 8.0–12.0 GHz are developed, and the electrophysical parameters, composition and concentration of components of the composite materials for such microwave absorbers are determined. The systems for active protection of speech information that use combined masking signals consisting of “white” noise and speech-like signals as masking signals, along with “white” noise are considered. Criteria have been developed for the approach to selecting speakers and audiences when assessing speech intelligibility to solve problems of protecting speech information and methods for experimental studies of speech intelligibility against a background of masking acoustic noise. Technologies for the formation of nanocomposites based on carbon nanotubes and nanoparticles of ferromagnetic materials are presented to increase the degree of coherence of the spin texture at macroscopic distances, increase the degree of security of electronic products to strong magnetic ﬁelds and noise immunity. It has been shown that at certain concentrations of ferromagnetic nanoparticles, micromagnetic parameters increase, ensuring high performance of active elements in magnetic ﬁelds. The role of carbon in this case turns out to be decisive. The presented results seem promising for use in the creation of anechoic chambers, partitions for separating indoor zones intended for the location of electronic devices, products for protecting humans from the eﬀects of electromagnetic radiation in the microwave range, and the formation of combined masking signals in the form of “white” noise for devices protection of speech information, composite coatings to level out the eﬀects of a constant magnetic ﬁeld on electronic products.
Classification of Various Factors That Have Caused Major Fluctuations in Cryptocurrency Markets
Authors: Shankar Raja M. Anand , Priyadarshini D. Benita , Govindaraj Janani , Agarwal Saket
Published: April 2024

Cryptocurrency is a commonly used term in the current world, and the COVID-19 pandemic has indirectly increased the awareness and the investor base for cryptocurrencies. Various research has been conducted to understand the complex working structure of these investment options and to analyse the volatile nature of cryptocurrencies. There are multiple factors and triggers that impact the price movements in the crypto market. Classifying these factors would help streamline the process of analysing these factors for further studies. These factors cause both positive and negative impacts on the price fluctuations. Classifying the major factors under the period of impact will help understand each factor's role in the market. This classification would help in the diagnostic and prescriptive analysis of cryptocurrencies. In this research, well-cited and published research papers, journals, and articles have been studied to classify some of the major factors affecting cryptocurrencies carefully. A model has been created to easily comprehend the classification of factors based on time of impact. This model simplifies the understanding of the factors and would help conduct further analysis on these factors.
Role of Human Resource Management (HRM) in Marketing
Authors: Kumar Jha Shankar
Published: April 2024

Although the businesses make evident that the conventional marketing keeps mainly changed to the online marketing systems. Similarly, conventional human resource management(HRM) as well keeps changed to electronic human resource management. This provides the HRM leaders to search the emerging concept of operating amenities for themselves as well as theirs customers (employees).
Online or digital marketing as well creates the HRM leaders to feel such as a marketing manager/or specialist for acquiring the people of quality or high class applicants(or candidates) to theirs businesses. Hence, it should be understood the value and effectiveness of online marketing in the current and forthcoming period to improved performance and effectiveness.
For this purpose, the HRM practicing evidently living like a facilitator or catalyst to the workforce in-order-to lives the brands is reflecting into theirs sense of self-worth as well as branding name associated with the feelings and behaviours. Basically, in relation to brand strategies implementation, the HRM requires for engaging and play a part proactively into the procedures.
Today's HRM have played an important role into injecting online marketing strategy into theirs engagement and hiring and another workforce associated duties and responsibilities. Currently, the utilisation of digital job openings turn out to be a global tendency into the businesses that keeps transformation for utilising social networking websites to top-notch talents
Today's companies are operating comprehensively for keeping a leading position of trending technology for training and development, hiring and recruiting, as well as talent acquisition and management. Besides that, HRM professionals sustain progressively toward being the more appreciated pillars of the company. And the acceptance of online social networking platform strategies, HRM are shifting out of playing a part of finding employment for genuine branding associated oneself with.
The role of HRM leaders has been transformed drastically including the employees as well as financial system and which trends would follow a computerised and HRM automation/or robotics take over the jobs ever performing through individuals. Although which contributes nothing build employees and the HRM teammates which operate as well themselves equally importantly.
Today's HRM leaders are greater, progressive, as well they must be getting technically competent, adaptive and flexible, agile sufficient for handling a progressively marketing motivated list of tasks.
The aim of this research paper is to examine the role of HRM in marketing and provides invaluable insights and understanding in the context of improvement, supporting, increasing of brand image into the businesses. The subjective study research method was used. The semi- structured interview with industry experts in the field space to reveal advisory, personal standpoint, ideas as well as insights on specialists and thus it was discussed to be acceptable for this academic research.
Exploring Mental Accounting Through Financial Accounting: An Elementary Approach
Authors: Jose Jeswin
Published: April 2024

This paper makes a novel attempt to analyse the mental accounting process through the eyes of financial accounting. Financial accounting is pretty familiar in the accounting and overall commerce domain. But still, mental accounting is not much familiar among the masses. Financial accounting is a process that is employed by those companies which are supposed to follow the process by law. But the interesting fact is that every person is knowingly or unknowingly going through the mental accounting process in their day-to-day life. So, the paradox is that people are knowingly or unknowingly people involved but they are not familiar with that. The awareness of mental accounting can put people into an uncomfortable position as they are comfortable in feeling they are rational. Even though it is said unfamiliar to many, it has got a rich existing literature in its mother field of behavioural economics.