bluuebunny/crossref_metadata_2025 huggingface dataset:
The New Development Economics as a Methodological and Ideological Discipline
Authors:   Financial University under the Government of the Russian Federation, Tolkachev Sergey А. , Levin Sergey N. ,   Financial University under the Government of the Russian Federation, Makarova Irina V. ,   Financial University under the Government of the Russian Federation
Published: April 2024

The article is devoted to the description of a fundamentally new configuration of the discipline "Development Economics", offered as a theoretical understanding of modern transformation processes in the world economy. The discipline is designed for master's programs of economic directions of training, although it is built on the basis of an interdisciplinary approach. It is shown that the traditional courses on development economics, formed in the West in recent decades, were aimed at explaining the economic backwardness of developing countries and developing recommendations for overcoming the lag in the framework of globalization logic of the world economy development. The problems of developing countries and recipes for economic modernization have been presented in the format of macroeconomic models and institutional explanatory schemes, which do not reflect the much deeper causes of underdevelopment. At the beginning of the 21st century, the topics of Western courses were supplemented with global challenges of human development – inequality and poverty, environmental pollution, the UN Sustainable Development Goals, the "green agenda", and so on. However, these problems are also treated within the framework of the devalued globalist agenda. The ongoing deglobalization and the search for a new world economic order have devalued the theoretical background of traditional development economics. In the proposed new discipline, the problem of modern economic development is revealed with the help of geographical, geo-economic, long-term technological, institutional factors, with the involvement of the latest research in the framework of economic theory and related scientific directions of both domestic and foreign authors. The authors propose a competitive non-equilibrium paradigm of economic processes as the basic ontological concept of the course, in contrast to the implicitly existing equilibrium paradigm in the standard versions of the course "Development Economics".
Using Structural Equation Modeling to Investigate the Neural Basis of Altered Pain Processing in Fibromyalgia with Functional Magnetic Resonance Imaging
Authors: Warren Howard , Ioachim Gabriela , Powers Jocelyn , Staud Roland , Pukall Caroline , Stroman Patrick
Published: April 2024

Participants with fibromyalgia (FM) and healthy controls (HC) experienced an identical ‘threat/safety’ experimental pain paradigm while undergoing functional magnetic resonance imaging (fMRI) to investigate the differences in pain processing between the two groups. In the ‘threat’ (Pain) imaging runs, participants were told that they would receive noxious heat stimuli to their right hands, calibrated to elicit subjectively moderate levels of pain. In the ‘safety’ (No-Pain) imaging runs, no stimulus was given. This design enabled the study of both continuous and reactive components of pain processing, as well as brain activity associated with anticipation and reward. The fMRI data were analyzed with a data-driven structural equation modeling approach, and significant group-level connectivity differences were identified in both study conditions, in both time periods of interest (Expectation, Stimulation). Group-level connectivity differences in the No-Pain condition occurred mainly during the expectation of pain, and involved regions associated with emotion and reward, suggesting FM may involve altered affective/reward processing. Group-level connectivity differences in the Pain condition occurred mainly during stimulation, with the FM group having decreased connectivity between the anterior cingulate cortex (ACC) and the amygdala, and increased connectivity between the posterior cingulate cortex (PCC) and the thalamus. The decreased ACC→Amygdala connectivity supports previous findings, suggesting FM likely involves altered responses in motivational-affective aspects of pain processing. The increased PCC→Thalamus connectivity may suggest the FM group experienced heightened saliency toward the noxious stimuli, which may contribute toward the mechanism which causes hyperalgesia in FM.
The Role of Vitamin D in Prevention, Treatment, and Health Recovery of COVID-19 Patients (Literature Review)
Authors: Simbolon Demsa
Published: April 2024

One non-pharmacological treatment for COVID-19 involves the consumption of vitamin D, which has been shown to positively impact the body's immune system. It can lower the risk of infection and contribute to both specific and non-specific immunity, including enhancing physical barriers, natural cellular immunity, and the adaptive immune system. However, further evidence is necessary to elucidate vitamin D's exact role in preventing, treating, and aiding recovery in individuals with COVID-19. This study aims to explore the role of vitamin D in preventing, treating severity, and promoting the recovery of individuals with COVID-19. Conducted through a literature review utilizing a summarized methodology, the study examines the findings regarding vitamin D's impact on the health outcomes of COVID-19 patients. The analysis of 11 relevant articles suggests that vitamin D does indeed play a crucial role in preventing, treating, and aiding recovery in individuals with COVID-19. It appears to reduce the severity of respiratory infections, strengthen the immune systems of COVID-19 patients, and potentially expedite recovery, as evidenced by shorter hospitalization periods among those supplemented with vitamin D.
MODERN TRENDS OF IMPROVEMENT OF THE INSTITUTE OF PUBLIC PROCUREMENT
Authors: Аскеров М.И. , Корнилов А.Р.
Published: April 2024

В статье рассматривается становление института государственных закупок в Российской Федерации, обозначаются современные тенденции и  перспективы его развития в  условиях внедрения цифровых технологий и специализированных инструментов в виде электронных торговых площадок. Предлагаются направления совершенствования ряда законодательных актов с целью повышения эффективности закупок для государственных и муниципальных нужд и оптимизации проводимых процедур.

The article examines the formation of the institute of public procurement in the Russian Federation, outlines the current trends and prospects for its development in the context of the introduction of digital technologies and specialized tools in the form of electronic trading platforms. Th e directions of improvement of a number of legislative acts are proposed in order to increase the efficiency of procurement for state and municipal needs and optimize the procedures carried out.
ANTI-CORRUPTION COMPLIANCE AS AN IMPORTANT PREREQUISITE FOR BUSINESS DEVELOPMENT
Authors: Зимин В.В.
Published: April 2024

Количество совершаемых преступлений коррупционной направленности в сфере бизнеса увеличивается с каждым годом. Законодательство, регулирующее правоотношения в данной сфере, нуждается в совершенствовании. Одной из задач криминологии является разработка эффективных методических рекомендаций предупреждения коррупции в сфере бизнеса. В статье отражены вопросы совершенствования антикоррупционных процедур. В частности, предлагается обратить внимание на криминологическое обеспечение антикоррупционного комплаенса.

The number of corruption-related crimes committed in the business sector is increasing every year. The legislation regulating legal relations in this area needs to be improved. One of the tasks of criminology is to develop effective methodological recommendations for preventing corruption in the business sector. This article addresses the issues of improving anti-corruption procedures. In particular, it is proposed to pay attention to the criminological provision of anticorruption compliance.
INHERITANCE CONTRACT AS THE BASIS OF INHERITANCE
Authors: Кирмикчи В.И. , Агаджанян М.А.
Published: April 2024

В статье рассматриваются основные положения, характеризующие наследственный договор как самостоятельный правовой институт российского права. Раскрыты понятие и элементы наследственного договора, особенности заключения, изменения и расторжения наследственного договора.

The article addresses the basic provisions which characterize an inheritance contract as an independent legal institute of Russian law. Concept and elements of an inheritance contract are revealed as well as features of conclusion, modification and termination of inheritance contract.
Comparing Carbon Regulation Scenarios for BRICS and EAEU Economies Using a GTAP-E Model
Authors: Altana Y. Davydova
Published: April 2024

The paper compares the economic effects of a national carbon tax with those of an emission trading system (ETS) between EAEU and BRICS countries over the medium term. Also included are Uzbekistan, which has observer status in the EAEU, and Turkmenistan, which is an EAEU trade and economic partner. The static computable general equilibrium model GTAP-E is employed. Targets for reducing emissions are formulated on the basis of the countries’ intermediate goals as stated in their respective submissions under the Paris Agreement. The resulting simulations show that, in terms of real GDP, an emission trading scheme would be more favorable than national taxation for countries such as Brazil, India, Russia, Armenia, Belarus, Kazakhstan, and Kyrgyzstan. However, for China, South Africa, Uzbekistan and Turkmenistan, resorting to an ETS would produce a comparatively greater reduction in GDP. Because the second group of countries has lower abatement costs than the equilibrium carbon price under an ETS, that scenario would permit those countries to reduce emissions by a greater amount and sell emission allowances. The analysis also shows which sectors would increase production after carbon regulation. A considerable increase in production and exports would occur for chemicals and for ferrous and nonferrous metals in several BRICS and EAEU countries. Although those industries are energy-intensive, the countries concerned could decrease emissions by reducing production in the energy or other sectors. These industries could benefit from potential joint comparative advantages in the context of declining demand for traditional energy sources. These findings should be valuable in devising integration policy.
The Effect of ICT Formation and Development on the Dynamics of Production Output
Authors: Lidia A. Burdina
Published: April 2024

The purpose of this article is to analyze how differentiation in the development of the ICT sector in terms of two kinds of indicators (for either “formative” or “characterizing” ICT) may affect a country’s or region’s economic output, a relationship which this study seeks to better understand. The research hypothesis is that the degree of impact on the economic indicators of a country’s development that is attributable to heterogeneity in the ICT sector, classified as either “formative” or “characterizing,” is not the same. To test this hypothesis, three types of models were constructed incorporating either general effects, fixed effects, or random effects. The impact on economic growth from control variables that are not directly related to the ICT sector was also tested. The results of the study indicate that the cumulative effect of a single unit increase in each of the components that make up the formative ICT factors (because of development in related components) is greater than the effect from a like increase in components that are among the characterizing ICT factors; and this different impact produces in a 7.96% increase in GRP per capita. The authors’ expectations about the positive effects of a number of factors pertaining to labor resources and capital on the value of GRP per capita were also confirmed. One advantage of the proposed theoretical approach is that it permits the range of explanatory variables to be expanded and the dependent variable to be replaced by one consistent with the goals under consideration and the corresponding tools.
The Power of Nature in Managing Diabetes: A Database of Ethno Indigenous Plants in India
Authors: Ghosh Abhijit , Das Sonjit , Jana Koushik , Debnath Biplab , Das Joni , Mondal Sourin
Published: April 2024

The ethno anti-diabetic plant database of India is a comprehensive compilation of indigenous plants used in traditional medicine for the treatment of diabetes mellitus. This database contains information on 1305 plant species that have been reported to have anti-diabetic properties based on ethnobotanical surveys, scientific research, and traditional knowledge. The plants have been categorized according to their scientific name, family, local name, parts used and availability among the 29 States. The database aims to provide a valuable resource for researchers, healthcare professionals, and the general public to explore the potential of traditional medicine in the management of diabetes. It also highlights the need for further scientific investigations into the efficacy and safety of these plants for the development of new anti-diabetic drugs.
Venom Vanquish: A Comprehensive Review on Ethnobotany and Phytochemistry of Significant Traditional Medicinal Plants
Authors: T. Dhanya  , Kavinila S. , David Paul Raj R. S.
Published: April 2024

Snakebite is a significant public health concern in many parts of the world, particularly in regions where venomous snakes are prevalent. Snakebites can range from mild to life-threatening, depending on the species of snake, the amount of venom injected, and the location of the bite. Globally, an estimated 5 million people are affected by snake bites each year, according to recent statistics. Since ancient times, traditional medicinal plants have been used to cure a wide range of illnesses, including snake bites. Secondary metabolites contained in plants were efficient in reducing the effects of snake venom. Snake venom is a potent toxin that can cause severe damage to the human body, affecting the nervous system, cardiovascular system, or both. Symptoms can range from mild swelling to life-threatening paralysis, respiratory failure, and hemorrhage. Enzyme activity is inhibited by flavonoids, alkaloids, and tannins, which additionally hinder blood from clotting and lessen inflammation. Treatments for snake bites that are more beneficial and less hazardous could result from the isolation and synthesis of natural drugs. With the use of cutting-edge scientific methods, we can maximize their potential and use their secondary metabolites to develop novel medications and therapies. The study of these plants and their potential uses in contemporary medicine requires more funding and investigation. This will advance our knowledge of these plants and help us create cures for some of the most lethal diseases.
Exploring the Therapeutic Potential of Caesalpinia bonducella for Male and Female Reproductive Health: A Comprehensive Review
Authors: Muthuswamy Ragunathan , Ragunathan Ranil Ramana , Dharmalingam Senthil Rajan , Chidambaram Kumarappan , Pichaivel Manimekalai , Sanghavi
Published: April 2024

This review explores the potential of Caesalpinia bonducella Linn., particularly its seeds, known as ‘bounducella’ or ‘little ball’, and its impact on diverse pharmacological activities. Its use in treating various illnesses, including male and female reproductive health, has been investigated. The data, gathered from reliable sources worldwide, transcend language barriers and align with Indian Ayurvedic and Siddha Pharmacopoeias. This article has compiled the pharmacognostic and phytochemical profiles of the seeds, emphasizing their influence on reproductive health, potentially aiding in PCOS management and addressing hyperandrogenism. Additionally, the seed extract of this plant has abortifacient and anti-fertility effects, suggesting that it is a potential alternative to Mifepristone. Nevertheless, further in vivo and in vitro research on seed constituents is essential for developing lead molecules for use in allopathic treatment.
Ethno-Medico-Botanical Studies of Plant Resources of Beed District, Maharashtra, India: Retrospect and Prospects
Authors: Bhumbe Amar , Devarkar Vinod
Published: April 2024

The Beed district of Maharashtra, India, harbors a rich repository of ethnobotanical knowledge regarding medicinal plants. This review delves into the traditional wisdom of local communities, documenting the therapeutic applications of 191 plant species belonging to 61 families. The study reveals a diverse array of medicinal remedies derived from various plant parts, with leaves being the most commonly utilized. Skin diseases, gastrointestinal disorders, respiratory infections, and fever emerged as the primary ailments treated with these plant-based remedies. This comprehensive review underscores the urgent need for further ethnobotanical exploration within the district to meticulously document the traditional knowledge associated with medicinal plants and rigorously validate their efficacy through scientific investigation. Delving into the secrets of these medicinal plants might unveil a wealth of novel herbal remedies, all while protecting these invaluable natural treasures.
Study to Evaluate Correlation of Blood Sugar Level and Glycosylated Haemoglobin at the Time of Admission with Severity of Acute Coronary Syndrome in Diabetic Patients
Authors: Kodilkar Jitendra , Kolge Manish , Chafekar Neelima , Patil Mrunal
Published: April 2024

Aim: To study the clinical profile of diabetic patients who present with Acute Coronary Syndrome (ACS) for the first time, to correlate the Blood Sugar Level (BSL) and Glycosylated hemoglobin (HbA1C) at the time of admission and the severity of acute coronary syndrome; and to assess the correlation between tight glycemic control of diabetics based on HbA1C estimation and presence of end organ damage in diabetics. Materials and Methods: The study was undertaken at our medical college in the medicine department. 64 adult patients who are known diabetics or detected for the first time presenting in outpatient department or emergency department as acute coronary syndrome were studied. Study period was 2 years from January 2011 to December 2012. Results: The study showed a definite male preponderance, with 56.23% males as compared to 43.73% females. Atypical presentations of acute coronary syndrome were more common as compared to typical chest pain (34.37%). Chest pain commonly is prevalent in younger age group. 95.30% of the patient had some or other associated risk factors like hypertension (59.37%), smoking (26.56%), obesity (15.62%) or dyslipidemia (65.62%). ST elevation MI was the commonest presentation (73.40%) and involvement of anterior wall was common (36.20%). On admission BSL (Blood Sugar Level) was not found to have a definite prognostic value in predicting outcome in diabetic patients with acute coronary syndrome. Impaired glycosylated haemoglobin was found to be an independent risk factor and had a definite prognostic value in predicting outcome. Diabetic patient with acute coronary syndrome had LV dysfunction, cardiac rhythm abnormalities, cardiogenic shock and are likely to be readmitted, thus having worst morbidity as well as mortality. Conclusion: The primary aim of this study was to study correlation of blood sugar level and glycosylated haemoglobin at the time of admission with severity of acute coronary syndrome and to study clinical profile of diabetic patients with due consideration to complications which are related to diabetes.
Firm Specific Factors and Profitability of Indian Life Insurers
Authors: Adhikari Kingshuk , Ghosh Ankita
Published: April 2024

In the present competitive scenario, profit plays a major role in the survival and growth of every business enterprise in all sectors. Companies operating in the life insurance sector also face profitability contention with their rivals, especially among the private players who have entered the Indian market in a large number after the liberalization of the economy. The profitability of companies is affected by multiple factors which include firm-specific factors as well as external factors. In a competitive scenario, insurers having proper management of the controllable factors, i.e., the firm-specific factors may show better performance than others. Thus, the present paper tries to analyse the association of firm specific variables with the performance of life insurance companies operating in India. The impact of underwriting risk, company size, liquidity, volume of equity capital and tangibility on the performance of Indian life insurers have been analysed. A total of six life insurers operating in the Indian market have been taken as samples and annual statements for ten financial years, i.e., from 2010- 11 to 2019-20 have been used. Apart from basic descriptives, Correlation and Multiple Regression analysis have been used as statistical tools in the study. The findings reveal a positive relationship between Underwriting risk, Liquidity and Size of the company with profitability while Tangibility and Equity Capital have a negative relationship with profitability. Except for tangibility, the significant influence of all the firm-specific factors on the profitability of insurers has been observed in the study.
Does Remittance Promote Socio-Economic Development? Evidence from Bangladesh
Authors: Yousuf Md. , Ahmed Raju , Sumon Shah Md.
Published: April 2024

Bangladesh is promoting remittance inflows as it has become one of the main sources of foreign exchange. This paper investigates how remittances promote socio-economic development in Bangladesh by using the time series data for the period of 1990-2020. Unit root test shows that all variables are stationary at first difference. That is, integrated of order one I(1). The long-run relationship is ensured by the Johansen Cointegration approach. Finally, we use Vector Error Correction Model (VECM) to estimate the impact. The results confirm that remittances and HDI in Bangladesh are interrelated long-run. The long-run coefficient indicates that an increase in remittance inflow will promote socio-economic development measured by HDI. For the disaggregate Level, we examine the impact of remittances on per capita GDP, life expectancy, and years of schooling. In the long run, remittances promote per capita GDP, life expectancy, and years of schooling.
Work-Life Balance – Its Impact on Job Satisfaction among the Healthcare Workers in Senapati District, Manipur
Authors: Thro Ph Dale , Prasain Ganga Prasad
Published: April 2024

Healthcare workers play an essential role in our day-to-day lives. Their ability to stay focused on the job, stay satisfied with their job, and maintain a healthy balance between their professional work and personal lives are prudence for them to discharge their duty effectively and efficiently. As a cross-sectional study and quantitative investigation, this study focuses on the healthcare workers’ work-life balance and its impact on job satisfaction. Using random sampling, a questionnaire survey was conducted, which was analysed through IBM SPSS Statistics 21. To achieve the goals of the study, statistical tools like Cronbach’s Alpha, independent-sample t-test, exploratory factor analysis, and Pearson correlation coefficient are employed. The study found that 5 per cent of healthcare workers have no balance between work and personal life, while 72.3 per cent are moderately balanced and 22.7 per cent are highly balanced. The study also found that female and unmarried healthcare workers have significantly higher work-life balance than male and married workers, respectively. Work-life balance and job satisfaction were found to have a moderately positive relationship, suggesting a significant linear relationship between the two variables. Thus, top management and employers in the healthcare industry must improve the policies and initiatives relating to work-life balance to keep the employees satisfied. Further, such policies and initiatives should be framed strategically to maintain equality for all employees, mainly male and female and married and unmarried workers.
Образ жизни современных студентов и его влияние на здоровье и качество жизни
Authors: Кузина Е.С. , Николаева И.В.
Published: April 2024

Статья посвящена вопросу образа жизни современных студентов. Рассматриваются аспекты влияния образа жизни на здоровье студентов и качество их жизни. Приводятся способы популяризации здорового образа жизни среди студентов. Подчеркивается важность проведения спортивных мероприятий для привлечения студентов к здоровому образу жизни.
Баскетбол как спортивная деятельность и ее влияние на общую физическую нагрузку
Authors: Лапшина П.А. , Налимова М.Н.
Published: April 2024

Данная статья исследует баскетбол как спортивную деятельность и ее влияние на общую физическую нагрузку. Авторы рассматривают основные аспекты этого вид спорта, такие как бег, прыжки, маневрирование и использование верхней части тела. Анализируются физические требования к игрокам баскетбола и их влияние на общую физическую фитнес-уровень. Рассматриваются также преимущества баскетбола в качестве физической активности, включая улучшение кардио-сосудистой системы, координации движений и социальной взаимодействие.
Особенности структуры занятий фитнес-йогой в высшем учебном заведении
Authors: Литвин А.В. , Щеголева М.А.
Published: April 2024

В статье рассматриваются особенности применения элементов фитнес-йоги на занятиях физической культурой в высших учебных заведениях. Авторы охарактеризовали особенности структурных элементов занятия (разминки, основной и заключительной части), а также их воздействие на общее состояние организма. Авторы делают вывод, что занятия физической культурой с элементами фитнес-йоги имеют оздоровительный эффект, создают положительный эмоциональный настрой и помогают преодолевать ежедневные стрессы.
Современные популярные оздоровительные системы
Authors: Пронина М.С. , Николаева И.В. , Грязнов С.А.
Published: April 2024

В статье представлен обзор современных систем физических упражнений. Дается характеристика наиболее популярных оздоровительных систем. Рассматриваются причины популярности данных видов занятий.
Анализ методов утилизации нефтяных шламов
Authors: Максимов Е.А.
Published: April 2024

Качественная утилизация отходов, имеющих углеводородное происхождение, после технологических операций с нефтяными продуктами является важной экологической проблемой не только нефтегазового комплекса, но и всей промышленности в целом. В данной статье проанализированы методы утилизации нефтяных отходов, изучены достоинства и недостатки этих методов и рассмотрены способы их применения в нефтяной промышленности.
Оценка перспективности использования биотехнологий в очистке нефтепроводов
Authors: Максимов Е.А. , Добрянский Р.Ф.
Published: April 2024

Данная статья посвящена рассмотрению перспективы применения биотехнологий для очистки внутренней полости нефтепроводного транспорта. В статье представлен обзор современных методов очистки, применяемых разными компаниями по всему миру, эксплуатирующими трубопроводный транспорт нефти и нефтепродуктов, и их недостатки. Особое внимание уделено применению биотехнологий для решения задач по качественному и безопасному комплексу очистных мероприятий. Детально описан процесс биодеградации нефти и нефтепродуктов. Проведен анализ перспективности и подведены выводы о применимости биотехнологических методов в сфере очистки нефтепроводного транспорта.
Identification and synthesis of metabolites of the new antiglaucoma drug
Authors: Khokhlov Alexander L. , Yaichkov Ilya I. , Shetnev Anton А. , Ivanovsky Sergey A. , Korsakov Mikhail K. , Alexeev Mikhail A. , Gasilina Olga A. , Volkhin Nikita N. , Petukhov Sergey S.
Published: April 2024

Introduction: The determination of biotransformation products is an essential part of the preclinical trial of original medicines. These studies have not been conducted before for the new drug 5-[5-(trifluoromethyl)-1,2-oxazole-3-yl]-furan-2-sulfonamide. Identification and synthesis of metabolite substances are necessary for subsequent tests of bioavailability, linearity of pharmacokinetics, accumulation, distribution and excretion.
Materials and methods: The study was carried out on Wistar rats and rabbits of the Soviet Chinchilla breed. The substance of the drug was administered to animals intraperitoneally. The collection of animal blood samples was performed before administration and 1 h, 2 h, 4 h, 24 h after administration into K3EDTA-tubes. A part of each sample was centrifuged to separate the plasma. Rat urine samples were taken before administration and at intervals of 0-2 h, 2-4 h, 4-6 h, 6-24 h after administration of the drug. The HPLC-MS/MS method was used to identify metabolites in biological fluids. The assumed biotransformation products were synthesized after preliminary analysis. The structure of the obtained substances was confirmed by NMR spectroscopy and high-resolution mass spectrometry. Then, a comparison was carried out with the compounds identified in biological fluids by retention time, ratios of chromatographic peak areas at the main MRM-transitions using HPLC-MS/MS.
Results and discussion: A metabolite formed by addition an oxygen atom to a drug molecule, as well as an acylated metabolite were detected during the analysis of plasma and blood samples. A compound with an increased molecular weight of 1 dalton compared to the drug substance was also present in a rat urine. N-hydroxy-5-[5-(trifluoromethyl)-1,2-oxazole-3-yl]-furan-2-sulfonamide, 5-[5-(trifluoromethyl)-1,2-oxazole-3-yl]-furan-2-sulfonic acid, which could potentially be obtained during biotransformation, as well as N-acetyl-5-[5-(trifluoromethyl)-1,2-oxazole-3-yl]-furan-2-sulfonamide were synthesized. Repeated HPLC-MS/MS tests confirmed the correctness of the initial hypothesis. It was found that a sulfonic acid derivative is formed in urine as a result of decomposition of N-hydroxymetabolite during sample collection.
Conclusion: The studied drug is metabolized by formation of two metabolites: N-hydroxy-5-[5-(trifluoromethyl)-1,2-oxazole-3-yl]-furan-2-sulfonamide and N-acetyl-5-[5-(trifluoromethyl)-1,2-oxazole-3-yl]-furan-2-sulfonamide. N-hydroxymetabolite is able to decompose in biological fluids samples with formation of 5-[5-(trifluoromethyl)-1,2-oxazole-3-yl]-furan-2-sulfonic acid.
Artificial neural network with dynamic synapse model
Authors:   National Research Lobachevsky State University of Nizhny Novgorod, Zimin Ilya , Kazantsev Viktor ,   National Research Lobachevsky State University of Nizhny Novgorod, Stasenko Sergey ,   National Research Lobachevsky State University of Nizhny Novgorod
Published: April 2024

The purpose of this study is to develop and investigate a new short-term memory model based on an artificial neural network without short-term memory effect and a dynamic short-term memory model with astrocytic modulation. Methods. The artificial neural network is represented by a classical convolutional neural network that does not have short-term memory. Short-term memory is modeled in our hybrid model using the Tsodyks-Markram model, which is a system of third-order ordinary differential equations. Astrocyte dynamics is modeled by a mean field model of gliotransmitter concentration. Results. A new hybrid short-term memory model was developed and investigated using a convolutional neural network and a dynamic synapse model for an image recognition problem. Graphs of dependence of accuracy and error on the number of epochs for the presented model are given. The sensitivity metric of image recognition d-prime has been introduced. The developed model was compared with the recurrent neural network and the configuration of the new model without taking into account astrocytic modulation. A comparative table has been constructed showing the best recognition accuracy for the introduced model. Conclusion. As a result of the study, the possibility of combining an artificial neural network and a dynamic model that expands its functionality is shown. Comparison of the proposed model with short-term memory using a convolutional neural network and a dynamic synapse model with astrocytic modulation with a recurrent network showed the effectiveness of the proposed approach in simulating short-term memory.
Social-Philosophical Analysis of the Problems of Nomophobia and Internet Addiction
Authors: Lokova Mariana Yu. , Khanova Marina N. , Zakhokhova Madina R.
Published: April 2024

The social consequences of the problems of nomophobia and Internet addiction among young people are explored. The features of the development of network technologies are considered. Structural changes in the worldview of Russian youth and their adaptation to the new realities of living space are analyzed. Nomophobia is defined as a person’s ability to depend on technology, and the constructive and destructive consequences of this phenomenon are noted. The issue of human freedom in the digital space is raised. The role of information technology in the formation of a young person’s identity is studied. It is emphasized that nomophobia and Internet addiction are an external manifestation of a child’s internal problems, and therefore it is necessary first of all to pay attention to relationships within the family.
Geography of Insults of the Imperial Family Members in the Don Army Region at the Beginning of the 20th Century
Authors: Sleptsov Alexander S.
Published: April 2024

Studies of political culture have a long tradition in Russian historiography. The main part of the articles is based on sources that were created in large cities. Often traditional research leaves out information about the political consciousness of the rural population. The source of insults to the royal person can give us information that concerns political images, rumors, symbols, primarily of the population that did not live in large centers. The insults to the royal authority in the Don Army Region in the period 1904-1914 were analyzed in this article. This region is interesting for its specificity both in its ethnosocial composition and in administrative and economic law. A database was created based on the cases. Using the data grouping method, social and territorial specifics were identified. A comparative analysis of the percentage of crimes against the imperial family and the total number of territory inhabitants was carried out. The main points of conflict between representatives of various social groups have been identified. The inclusion in the historical context allowed not only to focus on individual markers but also to identify links between individual socio-political characteristics.
Chronic Rhinosinusitis With Nasal Polyps Does Not Affect the Association Between the Nasal Provocation Test and Serum Allergen-Specific Immunoglobulin E Levels
Authors: Yoon HyoungSun , Kwak Il-Youp , Kim KyungSoo , Min Hyun Jin
Published: April 2024

Background and Objectives: This study compared nasal provocation test (NPT) results between groups with and without chronic rhinosinusitis with nasal polyps (CRSwNP) to investigate whether CRSwNP affects the response to the intranasal allergen challenge.Methods: We reviewed the medical records of patients who had undergone the NPT, multiple allergen simultaneous test (MAST), and paranasal sinus computed tomography. Patients were diagnosed with CRSwNP based on findings from nasal endoscopy and paranasal sinus computed tomography. The NPT for house dust mites was conducted, and a positive MAST diagnosis was determined when the levels of immunoglobulin E specific to Dermatophagoides farinae and Dermatophagoides pteronyssinus were equal to or greater than 2 positives or at least 0.70 IU/mL. We statistically analyzed the NPT results and their correlation with MAST outcomes, comparing the CRSwNP group to the non-CRSwNP group.Results: Out of 99 participants, 30 had CRSwNP and 69 did not. There were no significant differences between the groups regarding MAST positivity, eosinophil count, eosinophil cationic protein levels, or responses to intranasal house dust mite challenges. The presence of CRSwNP did not significantly influence the correlation between NPT outcomes and MAST results.Conclusion: The presence of CRSwNP did not influence the outcomes of the NPT or its correlation with the results of the MAST. Additional large-scale, longitudinal studies are warranted to validate these findings.
Specific surface area and microstructure of the surface of soil solid substrates of different genesis
Authors: Shiroyan M. M. , Umarova A. B. , Fedotova A. V. , Butylkina M. A.
Published: April 2024

The sorption characteristics of sand, peat, the arable layer of Moscow urbanozem and a mixture of these substrates were studied in conjunction with the surface topography of their solid phase, studied by scanning electron microscopy (SEM). The arable layer has the greatest ability to absorb nitrogen, and the peat substrate showed very low values of the sorbed gas. A different picture of the mutual arrangement of substrate sorption isotherms is observed when water vapour is used as a sorbing gas. Peat is distinguished by high values of sorbed moisture in the entire studied range of relative humidity. This leads to differences in the ranking of substrates by specific surface area in descending order of its values. So, the specific surface area by water sorption in the series: peat / arable layer / mixture / sand was: 420 / 72 / 45 / 4 m2/g, respectively. The given surface was ranked according to nitrogen sorption in a different sequence: 8.31 / 2.41 / 1.45 / 0.55 for the series: arable layer, mixture, peat and sand, respectively. The analysis of microstructural characteristics by the SEM method at various magnifications revealed the most developed, rough surface in the arable layer. It turned out to be geometrically the most diverse, even at magnification of ×20 000. The variety and heterogeneity of the relief of the interface of the phases leads to the appearance of hysteresis of the sorption/desorption curves. Its severity in the range of nitrogen vapor concentration in which hysteresis is detected, and in the maximum width of the hysteresis loop, also turned out to be the most significant in the arable layer. The very low nitrogen specific surface of peat, which is close to a sandy substrate, is associated with the presence of organic films draping and leveling the surface of peat particles, which was revealed by analyzing images obtained by scanning electron microscopy. The sorption of water showed their high hydrophilicity, which led to high values of substrate humidity in the entire studied range of relative humidity.
Podzolic-brown soils of the Far East on the Soil map of Russian Federation, scale 1 : 2.5 M, and their correlation with soils in the Russian soil classification
Authors: Ananko T. V. , Gerasimova M. I. , Savitskaya N. V.
Published: April 2024

Podzolic-brown forest soils on the Soil Map of Russian Federation, scale 1 : 2.5 M, are widespread on the plains and plateaus of the Far East, referred to the Eastern brown-forest-soil area in the scheme of soil-geographical zoning. There, in Primorye and Priamurye regions, they are confined to various parent rocks and to different climatic and biota conditions. In the Classification of Soils of Russia (2004, 2008), there are no direct analogues of podzolic-brown soils in the map legend. To name these soils in the Russian classification system, regional publications (N.A. Kreida, G.I. Ivanov, V.I. Roslikova et al., N.M. Kostenkov, E.A. Zharikova) were reviewed: morphological and physicochemical properties of podzolic-brown soils were assessed in terms of their compliance with the diagnostic criteria of their possible analogues in the Russian system. The comparison has shown that in Primorye, on stony-loamy-clayey derivates of hard rocks, podzolic-brown soils correspond to soddy-pale-eluvial-metamorphic soils with textural differentiation, on loamy-clayey lacustrine-alluvial and colluvial deposits – as dark-humus podbels. In the north, in Priamurye region, podzolic-brown gley soils have properties of both texture-differentiated soils with the BT diagnostic horizon and of soils with a specific cryogenic structure in the middle cryometamorphic horizon. In the ideology and nomenclature of the Russian classification system, the former are defined as mucky-podzolic gleyic soils, the latter soils, as depending on the intensity of surface gley and structure development, can be defined as cryometamorphic podzolized gleyzems, eluvial-metamorphic cryometamorphic gleyic soils, or gleyic svetlozems.
Brechas de género y corrupción: el fenómeno de las mujeres ninis en Colombia
Authors: Henao Orozco Nathalie
Published: April 2024

La aproximación teórico-práctica revela los aspectos que impiden el desarrollo productivo de las mujeres en Colombia, las relaciones de poder entre el género y la corrupción, y cómo estas ocasionan el fenómeno de pobreza multidimensional que alimenta la problemática nini. En este estudio se utilizó la metodología cualitativa descriptiva para el análisis documental de 85 documentos que detallan las características, tendencias y afectaciones al progreso integral de las mujeres, que promueven su condición de desocupación. Los hallazgos confirman que corrupción y género son las principales causas del fenómeno nini. Como conclusiones se ofrecen datos para la ampliación del estudio a partir del análisis de categorías como pobreza multidimensional, género y corrupción persistente en nuestro país.
Social Innovation for Conserving Textile-Craft Practices in Boyacá, Colombia
Authors: Moya Espinosa Pedro Ignacio , Cortes Rodríguez Nubia Consuelo , Socha López Juan Carlos
Published: April 2024

Social innovation is a strategy for solving problems in community settings that integrates the cooperation of different participants to promote better conditions. This article aims to identify how co-creation practices promote the preservation of artisan textile knowledge through knowledge management and interculturality in social and educational spaces in Nobsa, Boyacá, Colombia. It was a descriptive research that involved a population of textile artisans and students of an educational institution in the community. Focus groups and surveys were used to gather data on specific social aspects of the community under study. Social, educational, and business spaces were created through living laboratories that allowed the search for social alternatives to the pro-blems encountered. As a result, a knowledge management model based on the Nonaka and Takeuchi model was obtained, (1994), which responded to the research objectives and contributed to the reduction of acculturation of textile practices at the local l
Adaptation Strategies of the Colombian Hotel Industry During the Pandemic
Authors: López Cadavid Diego Alejandro , Restrepo Morales Jorge Aníbal , Vanegas López Juan Gabriel , Arango Mesa Maria Alexandra
Published: April 2024

Different aspects related to business dynamics motivate the design and execution of strategies. In the case of the Colombian hospitality industry, the recent price regulation, the emergence of disruptive technologies, and events affecting public health demonstrate the need to outline appropriate tactics that lead to an adequate contextualized implementation. This study proposes an Analytic Hierarchy Process (AHP) model to evaluate the set of tactics and strategies most applicable to these current situation alternatives faced by hoteliers in the city of Medellin. The results of the evaluation indicate that intensive, generic business and defensive strategies are the most preferred. In addition, as expected, the results suggest that the pandemic has the greatest weight and should therefore be selected by hotel companies as the priority alternative on which to focus their strategies.
KAPADOKYA BÖLGESİ YEREL HALKININ DESTİNASYON MARKA İMAJINA YÖNELİK ALGILARI
Authors: Gölgeli Kürşad , İlhan Hidayet
Published: April 2024

Turistler tarafından bir destinasyonun seçilmesindeki en önemli faktörlerden biri de destinasyonun imajı ve bölge için oluşturulan marka algısıdır. Bu çalışmada; destinasyon, marka ve imaj kavramları incelenmiştir ve Nevşehir ili Ürgüp ilçesinde yaşayan yerel halkın bölgenin destinasyon marka imajına yönelik algılarının belirlenmesi amaçlanmıştır. Bu doğrultuda; Ürgüp’te yaşayan, destinasyon merkezlerine yakın evlere sahip, turizm sektöründe çalışmayan, farklı meslek gruplarına mensup, 20-66 yaş aralığındaki yerel halktan gönüllü olanlara yüz yüze yarı yapılandırılmış görüşme tekniği uygulanmıştır. Yerel halka, Doxey (1975) ölçeği kullanılarak toplam 25 soru yöneltilmiştir. Görüşmeler ses kayıt cihazına kaydedilmiş ve konuşmalar yazıya dökülerek analiz edilmiştir. Yapılan analizler neticesinde; turizm ve sosyal sürdürülebilirlik kapsamında, Ürgüp yerel halkının bölgede turizmin gelişmesini desteklediği, turistlere karşı sevgi ve sempati beslediği, turistlerle aralarındaki etkileşimin kendilerine sosyal açıdan katkı sağladığı ve turizm sektörünün daha fazla geliştirilmesi gerektiğini düşündükleri çıkarımı yapılmıştır. Turizm ve çevresel sürdürülebilirlik kapsamında; Ürgüp’te turizmden kaynaklanmayan genel bir trafik sorunu olduğundan ve turizmden kaynaklanan bazı görüntü ve gürültü kirliliklerinden bahsedilmiştir. Turizm ve ekonomik sürdürülebilirlik ile ilgili olarak; katılımcıların tamamının turizm nedeniyle bölgedeki fiyatların artmasından duydukları rahatsızlığı dile getirdiğini; öte yandan bölgede turizmin yoksullukla mücadelede ekonomik altyapının gelişmesine katkı sağladığı görüşünde olduğunu söylemek mümkündür.
Penyelesaian khusus persamaan diferensial biasa ordo dua linier tak homogen dengan koefisien konstan untuk fungsi bagian demi bagian
Authors: Gunawan Gani
Published: April 2024

Spring mechanical vibration motion system with a damped degree of freedom and influenced by external forces, is mathematically expressed as an ordinary differential equation of order of two linear constant coefficients that are not homogeneous. If an external force acts on a stationary system expressed as a continuous function f(t) for any time t, then the system will experience mechanical vibrational motion which mathematically the equation of motion can be expressed as a superposition. The equation consists of  as a solution to a homogeneous form with mechanical vibrations  as a solution to a particular form. In terms of the particular solution  this article will show a mathematical way when f(t) is a continuous function section by part which is defined at an interval, such that the mechanical vibration motion equation is at the same time a special solution of the equation the mechanical vibration system.

Keywords: Vibration, Impulse Functions, ConvolutionMSC2020: 34A37
Regularisasi model pembelajaran mesin dengan regresi terpenalti pada data yang mengandung multikolinearitas (Studi kasus prediksi Indeks Pembangunan Manusia di 34 provinsi di Indonesia)
Authors: Khamidah Nur , Sadik Kusman , M Soleh Agus , Dito Gerry Alfa
Published: April 2024

This research intends to model high-dimensional data that contains multicollinearity in four machine-learning algorithms: Random Forest, K-Nearest Neighbor, XGBoost, and Regression Tree. Previously, regularization was carried out with penalized ridge regression, least absolute shrinkage and selection operator (LASSO) regression, and Elastic Net regression. A total of 100 predictor variables and 1 response variable which are the Development Index 2022 data of 34 provinces in Indonesia from BPS were used and standardized. The simulation is also applied to highly correlated data on two distributions, uniform and normal with parameter values taken from existing empirical data. The results showed that the ridge regularization method is the best for producing accurate and stable predictions. Furthermore, there was no difference in the root mean square error (RMSE) results between the data with standardization and without standardization, wherein all the data analyzed it was found that the kNN model was better than other models on simulation data, and the Random Forest and XGBoost models were better than other models on empirical data. In addition, the Regression Tree model is not recommended according to the results of this study.

Keywords: regularization, multicollinearity, ridge, LASSO, elastic netMSC2020: 62J07