bluuebunny/crossref_metadata_2025 huggingface dataset:
Performance vs. complexity in NN pre-distortion for a nonlinear channel
Authors: Imtiaz Hamza , Zheng Zibo , Homayoun Nejad Rizan , Rusch Leslie A. , Zeng Ming
Published: September 2023

Optical communications at high bandwidth and high spectral efficiency rely on the use of a digital-to-analog converter (DAC). We propose the use of a neural network (NN) for digital pre-distortion (DPD) to mitigate the quantization and bandlimited impairments from a DAC in such systems. We experimentally validate our approach with a 64 Gbaud 8-level pulse amplitude modulation (PAM-8) signal. We examine the NN-DPD training with both direct and indirect learning methods. We compare the performance with typical Volterra, look-up table (LUT) and linear DPD solutions. We sweep regimes where nonlinear quantization becomes more prominent to highlight the advantages of NN-DPD. The proposed NN-DPD trained via direct learning outperforms the Volterra, LUT and linear DPDs by almost 0.9 dB, 1.9 dB and 2.9 dB, respectively. We find that an indirect learning recurrent NN offers better performance at the same complexity as Volterra, while a direct learning recursive NN pushes performance to a higher level than a Volterra can achieve.
Ultralow noise C + L wideband WDM-IMDD transmission at 18 × 112 Gbps by using hybrid second-order distributed Raman and first-order lumped Raman amplification
Authors: Zhang Weiyu , Du Jiangbing , Tan Mingming , He Zuyuan
Published: September 2023

We experimentally investigated and demonstrated an ultralow noise hybrid amplifier that combines second-order distributed Raman amplifier (DRA) and first-order lumped Raman amplifier (LRA) in a cascaded approach. This approach allows for the reutilization of pump light from the LRA as the seed light in the second-order DRA, and simultaneous full-band dispersion compensation is realized by using dispersion compensation fiber in the LRA. This approach also supports broadband gain flattening based on the separated DRA and LRA configuration. The transmission application of the proposed amplifier was investigated using a set of 10 external cavity lasers (ECLs) in the C-band and 8 ECLs in the L-band. Ranging from 1531.12 nm to 1595.49 nm across C + L band, the proposed hybrid amplifier gives a maximum on-off gain of 27.2 dB and an average gain of 23.4 dB, with an extremely low effective noise figure (NF) of lower than -2.9 dB. Intensity modulation direct detection (IMDD) signal transmission is carried out at two different data rates across these 18 wavelengths in the C + L band: (1) 56 Gbps/λ PAM-4 signal; (2) 112 Gbps/λ PAM-4 signal. The results show that the error free transmissions are demonstrated over 101.6 km EX2000 fiber using both signals with 7% HD-FEC and 20% SD-FEC, respectively.
Partially decoupled polarization demultiplexing and phase noise equalizer for Alamouti code-based simplified coherent systems
Authors: Jin Taowei , Ling Hong , Zhang Jing , Qiu Kun
Published: September 2023

Alamouti space-time block code (STBC) combined with a simple heterodyne coherent receiver can realize polarization-insensitive phase-diversity detection to reduce the cost. In the receiver, a joint equalizer has been used for STBC’s polarization demultiplexing and phase tracking. However, the joint equalizer requires two different step size parameters to update the tap weight coefficients for polarization demultiplexing and the phase noise estimation. This leads to the search process being complex so requiring more iterations for convergence. In this paper, we propose a partially decoupled equalizer that consists of a polarization and phase decoupled equalizer (PPDE) and a pilot-aided blind phase search (P-BPS) algorithm to accelerate the convergence and improve the phase noise tolerance. By theoretically calculating the phase noise, the PPDE can achieve polarization demultiplexing with only one single step size parameter, thus suppressing the searching space and greatly reducing the iterations required for convergence. In the carrier phase recovery stage, the P-BPS algorithm can effectively improve the phase noise tolerance and solve the cyclic slip problem of BPS. We conduct numerical simulations and an experiment to transmit a quadrature phase-shift keying (QPSK) signal. The results demonstrate that the number of iterations required for PPDE convergence is only half of that of the joint equalizer while maintaining polarization-insensitive characteristics in large phase noise. Meanwhile, the achievable linewidth tolerance of P-BPS is increased by three times compared with DD-LMS.
Compact dual-focal augmented reality head-up display using a single picture generation unit with polarization multiplexing
Authors: Liu Yi , Dong Jiaqi , Qiu Yuqing , Yang Bo-Ru , Qin Zong
Published: September 2023

The augmented reality head-up display (AR-HUD) attracts increasing attention. It features multiple focal planes to display basic and AR information, as well as a wider field of view (FOV). Using two picture generation units (PGUs) to create dual-focal AR-HUDs leads to expanded size, increased cost, and reduced reliability. Thus, we previously proposed an improved solution by dividing one PGU into two partitions that were separately imaged into two virtual images with an optical relay system. However, the resolution of the PGU was halved for either virtual image. Regarding the drawbacks, this paper proposes a dual-focal AR-HUD using one PGU and one freeform mirror. Either virtual image utilizes the full resolution of the PGU through polarization-multiplexing. By performing optical design optimization, high image quality, except for the distortion, is achieved in an eyebox of 130 by 60 mm for far (10 m, 13° by 4°) and near (2.5 m, 10° by 1°) images. Next, we propose a distortion correction method by directly inputting the distorted but clear images acquired in the design stage into the real HUD with an inversed optical path. The proposed optical architecture enables a compact system volume of 9.5 L, close to traditional single-focal HUDs. Finally, we build an AR-HUD prototype, where a polarizing reflective film and a twisted nematic liquid crystal cell achieve polarization-multiplexing. The expected image quality of the two virtual images is experimentally verified.
Rapid detection of hydrogen using narrow bandwidth fiber-optic spectral combs with a low limit of detection
Authors: Cai Shunshuo , Nan Ying-Gang , Li Yuhang , Hou Yu , Zhang Zichen
Published: September 2023

The all-fiber detection solutions are the key technology to detecting hydrogen leakage in time because of the low explosive limit of the hydrogen-air mixture gas. However, most of the fiber-optic-based hydrogen sensing platforms must disrupt their structure to achieve a special architecture for interacting with the hydrogen. Here, we report a promising non-damaged structure of fiber-optic narrow bandwidth spectral combs, that can be developed to determine the refractive change as low as 10−5 using its cut-off cladding resonance mode. Such high performance of response for the refractive index induces a rapid detection of hydrogen after a proper thickness of palladium was deposited on the device. An average response time of hydrogen of 4 min with a low limit of detection of 348 ppm was achieved. It is demonstrated that these narrow bandwidth fiber-optic resonance combs can be used for gas detection after being combined with functional materials.
Power amplification for 1.6 µm high-order vortex modes
Authors: Hai Lan , Zhang Zhichao , Li Lang , Wang Kaixin , Zhang Xu , Yu Yang , Gao Chunqing , Fu Shiyao
Published: September 2023

1.6 µm high-order vortex modes carrying orbital angular momentums (OAMs) play significant roles in long-range Doppler lidars and other remote sensing. Amplification of 1.6 µm high-order vortex modes is an important way to provide high-power laser sources for such lidars and also enable the weak echo signal to be amplified so that it can be analyzed. In this work, we propose a four-pass Er:YAG vortex master-oscillator-power-amplification (MOPA) system to amplify 1.6 µm high-order vortex modes. In the proof-of-concept experiments, 1.6 µm single OAM mode (l = 3) is amplified successfully and the gain ranging from 1.88 to 2.36 is achieved. Multiplexed OAM mode (l=±3) is also amplified with favorable results. This work addresses the issue as the low gain of Er:YAG vortex MOPA, which provides a feasible path for 1.6 µm high-order vortex modes amplification.
A few essential genetic loci distinguish Penstemon species with flowers adapted to pollination by bees or hummingbirds
Authors: Wessinger Carolyn A. , Katzer Amanda M. , Hime Paul M. , Rausher Mark D. , Kelly John K. , Hileman Lena C.
Published: September 2023

In the formation of species, adaptation by natural selection generates distinct combinations of traits that function well together. The maintenance of adaptive trait combinations in the face of gene flow depends on the strength and nature of selection acting on the underlying genetic loci. Floral pollination syndromes exemplify the evolution of trait combinations adaptive for particular pollinators. The North American wildflower genus Penstemon displays remarkable floral syndrome convergence, with at least 20 separate lineages that have evolved from ancestral bee pollination syndrome (wide blue-purple flowers that present a landing platform for bees and small amounts of nectar) to hummingbird pollination syndrome (bright red narrowly tubular flowers offering copious nectar). Related taxa that differ in floral syndrome offer an attractive opportunity to examine the genomic basis of complex trait divergence. In this study, we characterized genomic divergence among 229 individuals from a Penstemon species complex that includes both bee and hummingbird floral syndromes. Field plants are easily classified into species based on phenotypic differences and hybrids displaying intermediate floral syndromes are rare. Despite unambiguous phenotypic differences, genome-wide differentiation between species is minimal. Hummingbird-adapted populations are more genetically similar to nearby bee-adapted populations than to geographically distant hummingbird-adapted populations, in terms of genome-wide dXY. However, a small number of genetic loci are strongly differentiated between species. These approximately 20 “species-diagnostic loci,” which appear to have nearly fixed differences between pollination syndromes, are sprinkled throughout the genome in high recombination regions. Several map closely to previously established floral trait quantitative trait loci (QTLs). The striking difference between the diagnostic loci and the genome as whole suggests strong selection to maintain distinct combinations of traits, but with sufficient gene flow to homogenize the genomic background. A surprisingly small number of alleles confer phenotypic differences that form the basis of species identity in this species complex.
Understanding the cervical cancer self-collection preferences of women living in urban and rural Rwanda
Authors: Nair Varun , Dau Hallie , Vidler Marianne , AboMoslim Maryam , Mutamba Barbra , Scott McKerron , Nesbitt Zoey , Deodatha John , Byiringiro Schadrack Danson , Niyotwiringiye Charles , Mithani Nadia , Smith Laurie , Ogilvie Gina , Rulisa Stephen
Published: September 2023

Cervical cancer is a leading cause of cancer among women in low- and middle-income countries. Women in Rwanda have high rates of cervical cancer due to limited access to effective screening methods. Research in other low-resource settings similar to Rwanda has shown that HPV-based self-collection is an effective cervical cancer screening method. This study aims to compare the preferences of Rwandan women in urban and rural settings toward self-collection and to report on factors related to self-collection amenability. A cross-sectional survey was conducted from June 1–9, 2022. Women were recruited from one urban and one rural clinic in Rwanda. Women were eligible for the study if they were ≥ 18 years and spoke Kinyarwanda or English. The survey consisted of 51 questions investigating demographics and attitudes towards self-collection for cervical cancer screening. We reported descriptive statistics stratified by urban and rural sites. In total, 169 urban and 205 rural women completed the survey. The majority of respondents at both sites had a primary school or lower education and were in a relationship. Both urban and rural respondents were open to self-collection; however, rates were higher in the rural site (79.9% urban and 95.6% rural; p-value<0.001). Similarly, women in rural areas were more likely to report feeling unembarrassed about self-collection (65.3% of urban, 76.8% of rural; p-value<0.001). Notably, almost all urban and rural respondents (97.6% urban and 98.5% rural) stated they would go for a cervical cancer pelvic examination to a nearby health center if their self-collected results indicated any concern (p-value = 0.731). Rwandan women in both urban and rural areas largely support self-collection for cervical cancer screening. Further research is needed to better understand how to implement self-collection screening services in Rwanda.
Increasing representation and diversity in health research: A protocol of the MYHealth research training program for high school students
Authors: Chuisano Samantha A. , Rafferty Jane , Allen Alison , Chang Tammy , Diemer Matthew , Harris Kara , Vaughn Lisa M. , Watkins Daphne C. , DeJonckheere Melissa
Published: September 2023

Background

Despite decades of calls for increased diversity in the health research workforce, disparities exist for many populations, including Black, Indigenous, and People of Color individuals, those from low-income families, and first-generation college students. To increase representation of historically marginalized populations, there is a critical need to develop programs that strengthen their path toward health research careers. High school is a critically important time to catalyze interest and rebuild engagement among youth who may have previously felt excluded from science, technology, engineering, and mathematics (STEM) and health research careers.

Methods

The overall objective of the MYHealth program is to engage high school students in a community-based participatory research program focused on adolescent health. Investigators will work alongside community partners to recruit 9ththrough 12thgraders who self-identify as a member of a group underrepresented in STEM or health research careers (e.g., based on race and ethnicity, socioeconomic status, first generation college student, disability, etc.). MYHealth students are trained to be co-researchers who work alongside academic researchers, which will help them to envision themselves as scientists capable of positively impacting their communities through research. Implemented in three phases, the MYHealth program aims to foster a continuing interest in health research careers by developing: 1) researcher identities, 2) scientific literacy, 3) scientific self-efficacy, and 4) teamwork and leadership self-efficacy. In each phase, students will build knowledge and skills in research, ethics, data collection, data analysis, and dissemination. Students will directly collaborate with and be mentored by a team that includes investigators, community advisors, scientific advisors, and youth peers.

Discussion

Each year, a new cohort of up to 70 high school students will be enrolled in MYHealth. We anticipate the MYHealth program will increase interest and persistence in STEM and health research among groups that have been historically excluded in health research careers.
Lexical competition in the flankers task revisited
Authors: Vandendaele Aaron , Grainger Jonathan
Published: September 2023

We investigated the impact of flanking stimuli that are orthographic neighbors of central target words in the reading version of the flankers task. Experiment 1 provided a replication of the finding that flanking words that are orthographic neighbors of central target words (e.g., BLUE BLUR BLUE) facilitate lexical decisions relative to unrelated word flankers (e.g., STEP BLUR STEP). Experiment 2 tested the hypothesis that this facilitatory effect might be due to the task that was used in Experiment 1 and in prior research–the lexical decision task. In Experiment 2 the task was perceptual identification, and here we observed that orthographic neighbor flankers interfered with target word identification. Experiment 2 also included a bigram flanker condition (e.g., BL BLUR UE), and here the related bigram flankers facilitated target word identification. We conclude that when the task requires identification of a specific word, effects of lexical competition emerge over and above the facilitatory effects driven by the sublexical spatial pooling of orthographic information across target and flankers, and that the inhibitory influence of lexical competition has an even stronger impact when flankers are whole words.
The endocytic receptor protein LRP-1 modulate P-glycoprotein mediated drug resistance in MCF-7 cells
Authors: Henry Aubery , Mauperin Marine , Devy Jerome , Dedieu Stephane , Chazee Lise , Hachet Cathy , Terryn Christine , Duca Laurent , Martiny Laurent , Devarenne-Charpentier Emmanuelle , Btaouri Hassan El
Published: September 2023

Multidrug resistance (MDR) is a major obstacle to successful cancer chemotherapy. A typical form of MDR is due to the overexpression of membrane transport proteins., such as Glycoprotein-P (P-gp), resulting in an increased drug efflux preventing drug cytotoxicity. P-gp is mainly localized on the plasma membrane; however, it can also be endocytosed resulting in the trafficking of P-gp in endoplasmic reticulum, Golgi, endosomes, and lysosomes. The lysosomal P-gp has been found to be capable of transporting and sequestering P-gp substrates (e.g., Doxorubicin (Dox)) into lysosomes to protect cells against cytotoxic drugs. Many translational studies have shown that low-density lipoprotein receptor-related protein-1 (LRP-1) is involved in endocytosis and regulation of signalling pathways. LRP-1 mediates the endocytosis of a diverse set of extracellular ligands that play important roles in tumor progression. Here, we investigated the involvement of LRP-1 in P-gp expression and subcellular redistribution from the cell surface to the lysosomal membrane by endocytosis and its potential implication in P-gp-mediated multidrug resistance in MCF-7 cells. Our results showed that MCF-7 resistant cells (MCF-7R) overexpressed the P-gp, LRP-1 and LAMP-1 and were 11.66-fold resistant to Dox. Our study also revealed that in MCF-7R cells, lysosomes were predominantly high density compared to sensitized cells and P-gp was localized in the plasma membrane and lysosomes. LRP-1 blockade reduced lysosomes density and level of LAMP-1 and P-gp. It also affected the subcellular distribution of P-gp. Under these conditions, we restored Dox nuclear uptake and ERK 1/2 activation thus leading to MCF-7R cell sensitization to Dox. Our data suggest that LRP-1 is able to modulate the P-gp expression and subcellular redistribution by endocytosis and to potentiate the P-gp-acquired Dox resistance.
Match analysis and probability of winning a point in elite men’s singles tennis
Authors: Prieto-Lage Iván , Paramés-González Adrián , Torres-Santos Daniel , Argibay-González Juan Carlos , Reguera-López-de-la-Osa Xoana , Gutiérrez-Santiago Alfonso
Published: September 2023

Notational analysis and new technologies have allowed a better understanding of tactical actions in tennis. In particular, the combined analysis of different variables affecting performance is necessary to understand the relationships between actions in competition. The aim of this research was to analyse the probability of winning a point in men’s professional tennis based on the most relevant variables affecting performance in this sport. A total of 4,669 points were analysed on three different court surfaces from the final rounds (from the quarter-finals onwards) of three of the four Grand Slam tournaments in the 2021 season. An observational methodology was applied. Different analysis techniques were used to obtain the results: descriptive and chi-square with a significance level of p<0.05. First serve effectiveness (point won) was 69% on clay, 75% on grass and 75% on hard court. Second serve effectiveness (point won) was around 55% regardless of the surface. The majority of points, between 65% and 77% depending on the court surface, ended with a short rally (between one and four shots). Approximately 80% of the points played with first serve and short rally were won by the serving player. With first serve and medium length rallies, the probability of winning the point is similar between server (range 49–55%) and receiver on any court surface. The study reveals a set of patterns (based on the combination of information from the variables analysed) that determine the probability of winning a point. Descriptive data from this research could help coaches and players on match strategy at the highest levels of elite men’s single tennis.
Adults’ reading engagement and wellbeing in Aotearoa New Zealand
Authors: Reder Stephen
Published: September 2023

Education and literacy have long been associated with a range of economic and social outcomes in industrialized societies. Recent research based on large-scale national and international surveys has examined effects of education and literacy on individuals’ social and economic outcomes. This paper takes a further step in understanding the importance of literacy for individuals’ economic and social outcomes by disentangling the effects of two different aspects of literacy,literacy proficiencyas measured by standardized tests andreading engagementas measured by self-reports of everyday reading activities. Using recent nationally representative survey data from New Zealand, multivariate regression models estimate the effects of reading engagement on earnings, health, social trust, political efficacy and civic engagement. Reading engagement has statistical and substantial positive effects on each of these outcomes with the effects of literacy proficiency, education and other important variables held constant. Although these results do not imply a causal relationship between reading engagement and the outcomes, they have important implications for policy and practice in adult education as well as for future research about the role of reading engagement in wellbeing more generally.
A deep learning algorithm with good prediction efficacy for cancer-specific survival in osteosarcoma: A retrospective study
Authors: Liu Yang , Xie Lang , Wang Dingxue , Xia Kaide
Published: September 2023

Objective

Successful prognosis is crucial for the management and treatment of osteosarcoma (OSC). This study aimed to predict the cancer-specific survival rate in patients with OSC using deep learning algorithms and classical Cox proportional hazard models to provide data to support individualized treatment of patients with OSC.

Methods

Data on patients diagnosed with OSC from 2004 to 2017 were obtained from the Surveillance, Epidemiology, and End Results database. The study sample was then divided randomly into a training cohort and a validation cohort in the proportion of 7:3. The DeepSurv algorithm and the Cox proportional hazard model were chosen to construct prognostic models for patients with OSC. The prediction efficacy of the model was estimated using the concordance index (C-index), the integrated Brier score (IBS), the root mean square error (RMSE), and the mean absolute error (SME).

Results

A total of 3218 patients were randomized into training and validation groups (n = 2252 and 966, respectively). Both DeepSurv and Cox models had better efficacy in predicting cancer-specific survival (CSS) in OSC patients (C-index >0.74). In the validation of other metrics, DeepSurv did not have superiority over the Cox model in predicting survival in OSC patients.

Conclusions

After validation, our CSS prediction model for patients with OSC based on the DeepSurv algorithm demonstrated satisfactory prediction efficacy and provided a convenient webpage calculator.
Complete continuum of maternity care and associated factors among mothers who gave birth in the last twelve months in Mekane Selam town North-East Ethiopia: A community-based cross-sectional study,2021
Authors: Mengistie Hibist Tilahun , Belay Mengistu Abate , Sendekie Abrham Debeb , Shitie Anguach , Sewyew Dagne Addisu
Published: September 2023

Background

Complete continuum of maternity care has significant value in improving the health and wellbeing of mothers and newborns. Assessing the complete continuum of maternity care is a global priority, particularly in developing countries. Despite the fact that the complete continuum of maternity care prevents more than half of all maternal and neonatal deaths, Ethiopia remains one of the largest contributors to the global burden of maternal and neonatal deaths due to the low implementation of the complete continuum of maternity care. Thus, this study aimed to assess the coverage of the complete continuum of maternity care and associated factors among mothers who gave birth in the last 12 months in the study area.

Methods

A community-based cross-sectional study with a multistage sampling technique was conducted among 479 mothers who gave birth in the last 12 months in Mekane Selam town. Data were collected from September 1 to November 30/2021 using an interviewer-administered questionnaire. Binary logistic regression analysis was computed. In multivariable logistic regression analysis, an adjusted odds ratio (AOR) with a 95% confidence interval (CI) and a P- value< 0.05 were used to identify significantly associated factors.

Results

The coverage of a complete continuum of maternity care was 42.4% (95% CI: 37.9%, 47%). Respondents with higher educational status (AOR = 4.17, 95% CI: 1.52, 11.44), pre-pregnancy contraception utilization (AOR = 3.53, 95% CI: 1.80, 6.92), planned pregnancy (AOR = 2.97, 95% CI: 1.27, 6.97) and early initiation of antenatal care (AOR = 4.57, 95% CI: 2.86, 7.31) were significantly associated with complete continuum of maternity care.

Conclusion

The coverage of complete continuum of maternal care was low in the study area. The coverage could be expanded by making the necessary interventions on the associated factors. It is essential for women to acquire education, utilize contraception, plan their pregnancies, and begin antenatal care at an early age in order to enhance the coverage of complete continuum of maternity care.
Financial crisis, labor market frictions, and economic volatility
Authors: Lei Wenni , Li Zhe , Mei Dongzhou
Published: September 2023

This article analyzes cross-country data encompassing 130 countries and regions from 2000 to 2019 to investigate the correlation between financial crises, labor market frictions, and economic volatility. The empirical findings demonstrate that financial crises have a milder impact on real gross domestic product (GDP) in developing countries with flexible labor markets. This trend also applies to non–eurozone developed countries, where labor market flexibility aids crisis mitigation. However, this pattern doesn’t hold for eurozone countries. Further examination of developing nations reveals that those with heightened labor market flexibility tend to experience reduced adverse effects on non-tradable sectors, thereby mitigating the impact on real GDP.
Bayesian network predicted variables for good neurological outcomes in patients with out-of-hospital cardiac arrest
Authors: Shinada Kota , Matsuoka Ayaka , Koami Hiroyuki , Sakamoto Yuichiro
Published: September 2023

Out-of-hospital cardiac arrest (OHCA) is linked to a poor prognosis and remains a public health concern. Several studies have predicted good neurological outcomes of OHCA. In this study, we used the Bayesian network to identify variables closely associated with good neurological survival outcomes in patients with OHCA. This was a retrospective observational study using the Japan Association for Acute Medicine OHCA registry. Fifteen explanatory variables were used, and the outcome was one-month survival with Glasgow–Pittsburgh cerebral performance category (CPC) 1–2. The 2014–2018 dataset was used as training data. The variables selected were identified and a sensitivity analysis was performed. The 2019 dataset was used for the validation analysis. Four variables were identified, including the motor response component of the Glasgow Coma Scale (GCS M), initial rhythm, age, and absence of epinephrine. Estimated probabilities were increased in the following order: GCS M score: 2–6; epinephrine: non-administered; initial rhythm: spontaneous rhythm and shockable; and age: <58 and 59–70 years. The validation showed a sensitivity of 75.4% and a specificity of 95.4%. We identified GCS M score of 2–6, initial rhythm (spontaneous rhythm and shockable), younger age, and absence of epinephrine as variables associated with one-month survival with CPC 1–2. These variables may help clinicians in the decision-making process while treating patients with OHCA.
Temporal trends in reptile occurrence among temperate old-growth, regrowth and replanted woodlands
Authors: Lindenmayer David B. , Florance Daniel , Smith David , Crane Clare , Siegrist Angelina , Lang Eleanor , Crane Mason , Michael Damian R. , Scheele Ben C. , Evans Maldwyn John
Published: September 2023

Reptiles are an important part of the vertebrate fauna in the temperate woodlands of south-eastern Australia. However, compared to birds and mammals, the long-term occurrence of reptiles across woodland growth types–old growth, regrowth, and replantings–remains poorly understood. Here, using 18-years of data gathered at 218 sites across 1.5 million hectares in New South Wales South West Slopes bioregion, we sought to quantify patterns of temporal change in reptile occurrence and determine if such changes varied between woodland growth types. Despite extensive sampling, almost 75% of our 6341 surveys produced no detections of reptiles. Significant survey effort exceeding 2000 surveys was needed over a prolonged period of time to record detections of 26 reptile species in our study area. Our analyses showed a temporal increase in estimated reptile species richness and abundance over 18 years. Such increases characterized all three vegetation structural types we surveyed. At the individual species level, we had sufficient data to construct models for five of the 26 species recorded. Three of these species were least commonly detected in replantings, whereas the remaining two were most often detected in replantings relative to old growth and regrowth woodland. We found evidence of a temporal increase in two skink species, a decline in one gecko species, and no change in the remaining two skink species. Although detections were consistently low, active searches were the best survey method, and we suggest using this method in habitats known to be hotspots for reptiles, such as rocky outcrops, if the aim is to maximize the number of individuals and species detected. Our findings highlight the value of all three broad vegetation structure types in contributing to woodland reptile biodiversity.
Validation of the English version of the Autism-Spectrum Quotient in an English-speaking Singaporean sample
Authors: Tan Rachael , Ashwin Chris
Published: September 2023

The Autism-Spectrum Quotient (AQ) measures the degree of autistic traits in clinical and non-clinical samples and has been validated in various countries and languages. However, the AQ has not been validated in Singapore, an Asian country whose population speaks predominantly English. Although previous validation studies have examined the distribution of scores, internal consistency, test-retest reliability and construct, convergent and discriminant validities in Asian countries using translated versions of the AQ and generally shown a suitable structure of the AQ, other studies testing cultural differences of the AQ have provided inconsistent results about whether differences exist in scores between Western and Asian samples. Additionally, while prior literature has consistently documented sex differences in AQ scores, findings about the relationship between personality traits and friendship quality with autistic traits have been mixed. The aim of the current study was to validate the psychometric properties of the original English AQ in a non-clinical Singaporean sample and compare their mean AQ scores to previous Western samples. In this study, psychometric properties of the original English AQ were assessed in 113 Singaporean adults (47M/66F; Mean age = 37.78; SD = 14.52) with no clinical diagnoses. They completed the AQ, the Friendship Questionnaire (FQ) and the short Big Five Inventory, with a subsample completing the AQ twice within three to six months. Results showed that AQ scores were normally distributed and the AQ had satisfactory internal consistency and test-retest reliability and it demonstrated construct, convergent and discriminant validities. Higher AQ scores were related to lower friendship quality and extraversion and higher neuroticism. The mean AQ scores of the Singaporean sample did not differ to that reported in original British sample. Together, present findings showed the original English AQ to be reliable for measuring the degree of autistic traits in a non-clinical Singaporean sample, producing comparable AQ scores and showing the same relationships to other social and personality measures and the same sex differences as has been reported in English samples. This supports the use of the AQ in Singapore for clinical and research purposes and suggests that the measurement of autistic traits in some Asian cultures is comparable to that reported in Western cultures.
Changes in myocardial blood flow in a canine model of left sided breast cancer radiotherapy
Authors: Chau Oi-Wai , El-Sherif Omar , Mouawad Matthew , Sykes Jane M. , Butler John , Biernaski Heather , deKemp Robert , Renaud Jennifer , Wisenberg Gerald , Prato Frank S. , Gaede Stewart
Published: September 2023

Background

Left-sided breast cancer patients receiving adjuvant radiotherapy are at risk for coronary artery disease, and/or radiation mediated effects on the microvasculature. Previously our laboratory demonstrated in canines with hybrid 18FDG/PET a progressive global inflammatory response during the initial one year following treatment. In this study, the objective is to evaluate corresponding changes in perfusion, in the same cohort, where resting myocardial blood flow (MBF) was quantitatively measured.

Method

In five canines, Ammonia PET (13NH3) derived MBF was measured at baseline, 1-week, 1, 3, 6 and 12-months after cardiac external beam irradiation. MBF measurements were correlated with concurrent 18FDG uptake. Simultaneously MBF was measured using the dual bolus MRI method.

Results

MBF was significantly increased at all time points, in comparison to baseline, except at 3-months. This was seen globally throughout the entire myocardium independent of the coronary artery territories. MBF showed a modest significant correlation with 18FDG activity for the entire myocardium (r = 0.51, p = 0.005) including the LAD (r = 0.49, p = 0.008) and LCX (r = 0.47, p = 0.013) coronary artery territories.

Conclusion

In this canine model of radiotherapy for left-sided breast cancer, resting MBF increases as early as 1-week and persists for up to one year except at 3-months. This pattern is similar to that of 18FDG uptake. A possible interpretation is that the increase in resting MBF is a response to myocardial inflammation.
On the impact of urban planning in contexts with limited enforcement of building and planning regulations: A study of the urban form of planned and unplanned informal settlements in Maputo, Mozambique
Authors: Mottelson Johan
Published: September 2023

Background

More than one billion people live in informal settlements under precarious conditions. Urban planning is considered an important instrument to mitigate compromised living conditions in informal settlements. However, limited studies have investigated the long-term impact of urban planning in contexts with limited capacity to enforce building and planning regulations. The purpose of this study is to assess the long-term impact of urban planning on the development of sustainable urban form in contexts characterized by unregulated urban development.

Methods

The study conducted geospatial surveys of three urban areas in Maputo, Mozambique covering adjacent planned and unplanned settlements that were established more than 40 years ago and subsequently developed with limited enforcement of building and planning regulations. High-resolution maps were produced and six urban form metrics were computed for the planned and unplanned areas respectively, providing the basis for quantitative and qualitative comparative analysis.

Results

Although the study found signs of street encroachment and appropriation of the public space in the planned areas, the study found higher levels of built densities, higher proportions of public space, and higher average street widths in all planned areas compared to the respective neighboring unplanned areas. Furthermore, the statistical analysis consistently showed large effect sizes (Cohen’s d > 0.8) of urban planning on indicators of compact city development and access conditions.

Conclusion

The results underscore that planning of street fabrics and plot layouts can enhance compact city development, improve transportation conditions, and increase the feasibility of investments in infrastructure in contexts with limited capacity to administer the urban growth.
Enhanced and unenhanced: Radiomics models for discriminating between benign and malignant cystic renal masses on CT images: A multi-center study
Authors: Huang Lesheng , Feng Wenhui , Lin Wenxiang , Chen Jun , Peng Se , Du Xiaohua , Li Xiaodan , Liu Tianzhu , Ye Yongsong
Published: September 2023

Background

Machine learning algorithms used to classify cystic renal masses (CRMs) nave not been applied to unenhanced CT images, and their diagnostic accuracy had not been compared against radiologists.

Method

This retrospective study aimed to develop radiomics models that discriminate between benign and malignant CRMs in a triple phase computed tomography (CT) protocol and compare the diagnostic accuracy of the radiomics approach with experienced radiologists. Predictive models were established using a training set and validation set of unenhanced and enhanced (arterial phase [AP] and venous phase [VP]) CT images of benign and malignant CRMs. The diagnostic capabilities of the models and experienced radiologists were compared using Receiver Operating Characteristic (ROC) curves.

Results

On unenhanced, AP and VP CT images in the validation set, the AUC, specificity, sensitivity and accuracy for discriminating between benign and malignant CRMs were 90.0 (95%CI: 81–98%), 90.0%, 90.5% and 90.2%; 93.0% (95%CI: 86–99%), 86.7%, 95.2% and 88.3%; and 95.0% (95%CI: 90%-100%), 93.3%, 90.5% and 92.1%, respectively, for the radiomics models. Diagnostic accuracy of the radiomics models differed significantly on unenhanced images in the training set vs. each radiologist (p = 0.001 and 0.003) but not in the validation set (p = 0.230 and 0.590); differed significantly on AP images in the validation set vs. each radiologist (p = 0.007 and 0.007) but not in the training set (p = 0.663 and 0.663); and there were no differences on VP images in the training or validation sets vs. each radiologist (training set: p = 0.453 and 0.051, validation set: p = 0.236 and 0.786).

Conclusions

Radiomics models may have clinical utility for discriminating between benign and malignant CRMs on unenhanced and enhanced CT images. The performance of the radiomics model on unenhanced CT images was similar to experienced radiologists, implying it has potential as a screening and diagnostic tool for CRMs.
Contract doctors’ strike in Malaysia: A content analysis of the perception of medical fraternity and stakeholders on Facebook
Authors: Jinah Norehan , Lee Kun Yun , Zakaria Nor Haniza , Zakaria Nursyahda , Ismail Munirah , Mohmad Shazwani
Published: September 2023

Contract appointment policy for newly graduated medical officers was implemented by the Ministry of Health Malaysia in 2016 to overcome the lack of permanent posts. Contract officers faced disadvantages in terms of salary, leave provision, and career prospects. A nationwide strike, Hartal Doktor Kontrak (HDK) was organised on 26th July 2021. Besides generating widespread public attention, HDK was also closely scrutinised by the medical fraternity and stakeholders. This content analysis aimed to explore how the medical fraternity and stakeholders viewed the strike as their perception would offer vital insights into the fundamental causes and viable solutions to the contract appointment policy. A qualitative content analysis of Facebook (FB) posts on the HDK strike was conducted from 1st June 2021 until 28th February 2022. A total of 182 FB posts were retrieved from stakeholders, medical fraternity groups, and medical key opinion personnel. Inductive coding was used in the thematic analysis to identify pertinent themes. Three main themes emerged: triggering factors, reactions to the strike, and outcomes of the strike. Factors that led to the strike included unequal treatment faced by contract officers, frustration with the government’s lack of long-term solutions, and aggravation by the COVID-19 pandemic. In terms of reactions, there was a mixture of supportive and opposing voices. No substantial negative impact on the healthcare service resulted from the strike. Instead, it generated widespread attention that propelled the government into implementing solutions to prevent adverse short and long-term consequences. Various suggestions were proposed, including the reform of human resource planning and undergraduate medical education. The results highlight the importance of proactive systemic measures by the government to prevent further strikes that may jeopardise healthcare provision. In summary, social media was found to influence the progress and outcome of HDK, thus demonstrating the impact of media influence on similar issues.
Knowledge and attitudes about conduct disorder of professionals working with young people: The influence of occupation and direct and indirect experience
Authors: Pinchess Chloe , Pauli Ruth , Tully John
Published: September 2023

Background

Knowledge and attitudes of professionals both pose a potential barrier to diagnosis and treatment of mental disorders. However, knowledge and attitudes about conduct disorder in professionals working with young people are poorly understood. Little is known about the impact of occupation, direct and indirect (training and education) experience, or the interrelationship between knowledge and attitudes.

Methods

We conducted an online survey of 58 participants, including Psychology Staff, Teaching Staff, Care Staff, and Other Non-Clinical Staff. A questionnaire comprising three subscales (causes, treatments, and characteristics) measured knowledge. A thermometer scale measured global attitudes. Open-ended response measures were used to measure four attitude components: stereotypic beliefs (about characteristics), symbolic beliefs (about the holder’s traditions), affect, and past behaviour. Primary analysis explored the impact of occupation, direct experience, and indirect experience on outcome measures. A secondary exploratory analysis was conducted to explore the relationship between knowledge and attitudes.

Results

Psychology Staff had significantly more favourable global attitudes (F = 0.49, p = 0.01) and symbolic beliefs (F = 0.57, p = 0.02) towards those with conduct disorder than Teaching Staff; there were no other significant group differences in attitudes. Psychology staff had more knowledge about conduct disorder than other groups, though the differences were not significant. Direct and indirect experience were associated with greater knowledge (direct: d = 0.97, p = 0.002; indirect d = 0.86, p = 0.004) and favourable global attitudes (direct: d = 1.12, p < 0.001; indirect: d = 0.68, p = 0.02). Secondary exploratory analyses revealed significant positive correlations between: all knowledge variables with global attitudes; total knowledge with past behaviour; and affect and knowledge of causes with past behaviour.

Conclusions

Psychology-based staff may have more favourable attitudes towards children with conduct disorder than teachers, primarily due to direct and indirect experience with the disorder. Our sample may have been too small to detect overall or within-group effects of knowledge or attitudes, however exploratory analyses showing a positive correlation between knowledge and attitudes suggest education may be critical in supporting teachers and other groups in their approaches to this challenging group of young people.
Quantum Chemical Studies on Structural, Spectral and Frontier Molecular Orbital Analysis of Indometacin in Aqueous Phases
Authors: YOGESWARI B. , DEIVANAYAKI S. , BANU A. SAJITHA , JAYANTHI E.
Published: September 2023

Density functional theory computations were done by using 6-31G(d) basis set in order to check out the solubility of indometacin in polar and non-polar solvents such as water, ethanol, acetone and diethyl ether, respectively. The quantum chemical parameters of indometacin in gaseous as well as in aqueous phases were calculated. The most stable structure (indometacin in water; IM-W) was found to be more stable with respect to the least stable complex (indometacin in diethyl ether; IM-D) by 3.14 Kcal/mol. The zero-point vibrational energy of indometacin in gas phase was found to be 197.731 Kcal/mol. The fundamental vibrational modes of indometacin were assignment and analyzed at B3LYP/6-31G(d) level of theory. The HOMO–LUMO analysis of indometacin showed that its HOMO is concentrated at its indole ring and LUMO is at its chlorophenyl group. The charge density distribution of indometacin was investigated through the molecular electrostatic potential map.
O niilismo em perspectiva: olhares, implicações e possibilidades sobre as teorias da Educação Física
Authors: Silva Fidel Machado de Castro , Nunes Mário Luiz Ferrari
Published: September 2023

Influenciados pelo filósofo alemão Friedrich Nietzsche e o conceito de niilismo, neste texto, navegamos pelos mares turbulentos do atual debate curricular, a fim de promover outros olhares para a Educação Física. Nesse bojo, levantamos implicações e possibilidades para pensar algumas teorias curriculares. Para dar conta do que se anuncia, em um primeiro momento, com a contribuição de Gilles Deleuze, centramos esforços em apresentar o niilismo em quatro perspectivas. A seguir, tensionamos algumas das perspectivas de Educação Física em voga, ao mesmo tempo em que tomamos a perspectiva do denominado currículo cultural da Educação Física em diálogo com algumas noções nietzschianas que contribuem para a existência dessa perspectiva-proposta-aposta. O que pretendemos é contribuir para que a ação de suspeitar das certezas sirva como subsídio, ação constante e mola propulsora para criar outras formas de pensar, sentir, agir e potencializar a afirmação da vida na sua integralidade, nas suas vicissitudes e paroxismos. O exposto nas linhas vindouras não possui pretensões universais ou de transformação social, mas de contribuir para o enfrentamento das condições anti-vida em que vivemos. Uma experiência estético-ética no campo da Educação Física, que ensaia uma aproximação com o debate do campo das teorias do currículo da Educação Física e o pensamento nômade de Nietzsche. Trata-se muito mais de uma proposta-aposta do que uma proposta-resposta.