bluuebunny/crossref_metadata_2025 huggingface dataset:
D-Psicose intake exacerbates DSS-induced colitis in mice through alteration in the gut microbiota and dysfunction of mucosal barrier
Authors: Wang Shuo , Zhang Xuejiao , Li Ang , Wang Yuanyifei , Wang Jin , Zhang Bowei , Zhang Yan , Liu Jingmin
Published: August 2022

D-Psicose, as a low-calorie rare sugar, has attracted a lot of attention in recent years for alternating to sucrose. The anti-obesity effect of D-Psicose has been extensively confirmed in previous studies, however, the impact of D-Psicose on colitis remains vague. Here, we firstly evaluated the effect of 21 days of D-Psicose prophylactic intervention on DSS-induced colitis in C57BL/6 mice. The pathological symptoms, inflammatory cytokines levels, gut microbiota composition, short chain fatty acids production and colonic barrier integrity were comprehensively evaluated. The results confirmed that D-Psicose intervention aggravated colitis, characterized by the exacerbation of colon shortening, increase of colonic inflammatory infiltration, and marked exaltation of disease activity indices and IL-6, IL-1β and TNF-α levels. Further, the dysfunction of gut microbiota was identified in the Psicose group. The abundance of pro-inflammatory bacteria Lachnospiraceae_NK4A136_group was significantly up-regulated while the abundance of probiotics Akkermansia and Lactobacillus were significantly down-regulated in the Psicose group compared to the Model group. Moreover, the production of short chain fatty acids was suppressed in the Psicose group, accompanied by a decrease in the level of Muc-2. Collectively, the underlying mechanism of the exacerbation of colitis by D-Psicose intervention might be attributed to microbiota dysfunction accompanied by the reduction of short chain fatty acids, which leads to the damage of the mucosal barrier and the intensification of inflammatory invasion.
Different responses of Japanese Encephalitis to weather variable among eight climate subtypes in Gansu China, 2005-2019
Authors: Li Ruifen , Zhao Xiaohong , Tian Yu , Shi Yanjun , Gu Xueyan , Wang Shuang , Zhang Rui , An Jing , Su Li , Wang Xuxia
Published: August 2022

This study evaluated epidemic temporal aspects of Japanese Encephalitis (JE) and investigated the weather threshold of JE response across eight climate subtypes between 2005 and 2019 in Gansu. Data were from the Centers for Disease Control (CDC) of Gansu. Three epidemic temporal indices (frequency index (α), duration index (β), and intensity index (γ)) were adopted for the comparison of epidemic features among different climate subtypes. In addition, the local indicators of spatial association technique (LISA) and category and regression tree model (CART) were used to detect the response threshold of weather variables in hot-spot areas across climate subtypes. Among eight climate subtypes in Gansu, a hot-spot(high-high cluster) of α, β, and γ were detected in the climate subtype of subtropical winter dry (Cwa), temperate oceanic continental (Cwb), and continental winter dry (Dwa, and the Dwb). CART analysis showed that the average temperature at a 1-month lag for JE may be the strongest predictor of JE response in Cwa. However, the maximum temperature at a 1-month lag for JE may be the strongest predictor of JE response in Cwb, Dwa, and Dwb.The climate subtypes of temperate arid (BWk) and subpolar winter dry (Dwc) in Gansu may be at the epicenter of an emerging pandemic. It is critical to increase preventive and control efforts in these areas. Cwa, Cwb, Dwa, and Dwb are the high-risk JE epidemic areas, where JE temperature at the lag of 1 month is the predominant variable of JE response.
Rapid monitoring of crop growth, grain exports, and fire patterns in Ukraine
Authors: Wellington Michael , Lawes Roger , Kuhnert Petra
Published: August 2022

Ukraine is an important global exporter of grain, especially to several countries with vulnerable food systems. The war in Ukraine may disrupt global food supply by limiting the planting, growth, and harvest of crops, or limiting grain supply logistics. We apply a statistical inference method to satellite images of cropland in Ukraine to investigate progress of the 2022 season. We also present satellite-derived cropland fire data and cargo shipping activity. We show that crop growth in 2022 has progressed similarly to a historical baseline, though total production is expected to be lower than 2019-2021. Cropland fires are present but are not significantly greater in spatial extent than a historical baseline. However, cargo shipping activity from Ukrainian ports declined to zero between March and June. Restoring operations at Ukraine ports to enable grain transport through the Black Sea is critical to mitigating global food shortages and severe food insecurity.
Sigma-1R overexpression in PVN deteriorated heart injury by upregulating sympathetic nerve tone
Authors: Wu Rui , Yu tingting , Chen xianglin , Yu Tian , Zhang Hong , Wang Haiying , Xiao Zhi , Li Ke , Cheng Chi
Published: August 2022

Sympathetic nerve tone chronically maintains at high level is harmful to heart. However, little is known how to control sympathetic nerve tone. It has been reported that sigma-1 receptors played a multi-functional role in central nervous system diseases, but little is known about the function for adjusting sympathetic tone of sigma-1 receptors within paraventricular nucleus (PVN). We examined the effects of sigma-1 receptor within PVN on heart by two models: cardiopulmonary bypass model (CPB) and cirrhotic cardiomyopathy (CCM) induced by bile duct ligation. It was found that sigma-1R overexpression in PVN aggravated brain inflammation and increased sympathetic output with more serious heart change. Right stellate ganglion block alleviated the cardiac damage caused by Sigma-1R overexpression in PVN during CPB. In CCM model, it was found that overexpression of sigma-1 receptor in PVN promoted occurrence of fibrosis and senescence in heart. These findings suggest that sigma-1R overexpression in PVN deteriorate heart injury by upregulating sympathetic nerve tone.
Clinical epidemiological characteristics of oral lichen planus and risk factors for erosive subtype: a multi-center cross-sectional study in China
Authors: Xu Hao , Chen Qianming , Dan Hongxia , Liu Jiaxin , Luo Xiaobo , Wang Jiongke , Zeng Xin , Jiang Lu , Zhou Y , Guoyao Tang , Liu Hongwei , Sun Zheng , Zhou Gang , Cheng Bin , Wang Wenmei , He Hong , Guo Bin , Meng Wenxia , Liu Qing
Published: August 2022

Oral lichen planus (OLP) is one of the most common oral mucosal diseases, which is often persistent and has the risk of potential malignant transformation. To explore the clinical epidemiological characteristics of OLP in China and risk factors for erosive subtype of OLP. We collected information of patients who are diagnosed with OLP through clinical and histopathological examinations from 11 hospitals in different regions of China from 2015 to 2018. Then the descriptive statistical methods were used to explore the clinical epidemiological characteristics and logistic regression and subgroup analysis were utilized to explore the risk factors for erosive subtype of OLP. We found that the average age of patients was 49.2 ± 13.3 years, and 61.4% of the patients were women. The ratios of patients with reticular, atrophic and erosive lesions were 47.9%, 27.8% and 24.2%, respectively. Analysis of risk factors for erosive subtype identified the following variables: age, course of disease of 12 months or more, II°-III° dental calculus, hypertension, diabetes, and heart disease, as well as regions of habitation. Subgroup analysis showed significant differences in risk factors for erosive subtypes in OLP patients with and without bad habits. In conclusion, our study demonstrated the clinical epidemiological characteristics of OLP patients in China and reflected a relationship between OLP erosive subtypes and epidemiological factors, providing a reference for prevention and treatment of erosive OLP.
Face Frontalization with Deep Gan via Multi-Attention Mechanism
Authors: Cao Jiaqian , Chen Zhenxue , Zhang Yujiao , Sun Luna , Chen Jiyang
Published: August 2022

In recent years, the development of deep learning has led to some advances in face synthesis approaches, but significant pose is remains one of the factors that is difficult to overcome. Benefiting from the proposal and development of generative adversarial network, the level of face frontalization technology has reached new heights. In this paper, we propose a deep generative adversarial network based on multi-attention mechanism (DMA-GAN) for multi-pose face frontalization. Specifically, we add a deep feature encoder based on the attention mechanism and residual block in the generator, which can deepen the network to extract more detailed features and make full use of the long-range dependencies between local features to generate better identity-preserving faces. Meanwhile, to carry the global and local facial information, the discriminator of our model consists of four independent discriminators. The self-attention mechanism is also added to these discriminators to provide more accurate synthesized details. The results from quantitative and qualitative experiments on CAS-PEAL-R1 dataset show that our model proves effective.
A Review of Sewerage and Drainage Systems Management in Sub-Saharan African Cities: Case of Abidjan, Côte d’Ivoire.
Authors: OUATTARA ZIE ADAMA , Ouattara Zié Adama , Kabo-bah Amos T. , Dongo Kouassi , Akpoti Komlavi
Published: August 2022

The malfunction of sewerage systems and rain water drainage networks is perceived as a very crucial problem by authorities in Côte d'Ivoire, both from an environmental point of view as well as the associated maintenance costs. This paper discusses the state of the sewerage systems, the malfunctions and environmental concepts used to categorize the problems, and the methodological options to prioritize the various management solutions. This review also presents the selection of decision support tools for sewerage asset management. The tools were classified according to their capability and functionality. The working principle of each of these tools was described and the corresponding data requirements were determined. Moreover, the paper discussed the problems associated with the use of existing tools and presents a perspective on future research needs in the field of decision support tools. This paper represents a comprehensive review of the sewage systems management challenges and can serve as a reference document for other developing countries in Sub-Saharan Africa.
miRNAs secreted by human blastocyst could be potential gene expression regulators during implantation
Authors: Eivazi Sadegh , Sabz Fatemeh Tanhaye Kalate , Amiri Sadegh , Zandieh Zahra , Bakhtiyari Mehrdad , Rashidi Mandana , Aflatoonian Reza , Mehraein Fereshteh , Amjadi Fatemehsadat
Published: August 2022

Background:Micro RNAs (miRNAs) are small non-coding RNAs known as essential regulators of cell-cell communication. Recent studies have revealed that miRNAs secrete by a blastocyst in culture mediums. We hypothesized that endometrial epithelial cells take up embryo-derived miRNAs and other soluble factors and regulate their receptivity-related genes expression.Methods and Results:Blastocyst culture mediums (BCM) were collected from the individually cultured embryos and, human endometrial epithelial cells (HEECs), were collected from healthy fertile volunteers. To evaluate the effect of BCM on the endometrial receptivity gene expression, HEECs were co-cultured with implanted BCM, non-implanted BCM, and a control culture medium. After determining altered gene expression in the HEECs, the miRNAs-related genes through bioinformatics databases were identified and evaluated in the BCM. Co-culture of primary HEECs with BCM significantly stimulated the expression levels of VEGFA, HBEGF, HOXA10, and LIF in the implanted group compared with non-implanted and control groups. The fold changes of miR‐195 significantly decreased in the implanted BCM group compared with the non-implanted BCM group. Also, we observed decreased fold changes of miR‐29b,145, and increased miR-223 in the implanted BCM group compared with the non-implanted ones.Conclusions:miRNAs' role as potential gene expression regulators during implantation. These molecules are secreted by human blastocyst, uptake by endometrial epithelial cells and cause a change in the endometrial function. We found that BCMs can be effective in implantation process by stimulating related receptivity gene expression, and BCM transfer with the embryo can be useful as an embryo implantation trigger.
Prognostic Awareness in Japanese Patients with Advanced Cancer: A Follow-Up Cohort Study
Authors: Hiratsuka Yusuke , Oishi Takayuki , Miyashita Mitsunori , Morita Tatsuya , Mack Jennifer W. , Imai Hiroo , Mori Takahiro , Sakayori Masato , Mori Masanori , Maeda Isseki , Hamano Jun , Ishioka Chikashi , Inoue Akira
Published: August 2022

Purpose Patients with advanced cancer have been reported to be more likely to receive goal-concordant care if they have accurate prognostic awareness. However, many patients do not have this awareness. This study aimed to examine prognostic awareness in Japanese patients with advanced cancer. Methods This single-center, follow-up cohort study included Japanese patients with advanced cancer who received chemotherapy at Tohoku University Hospital between January 2015 and January 2016. Patients were surveyed at enrollment and followed up for clinical events for 5 years thereafter. We compared (1) the patients’ prognostic awareness with both actual survival time and physician’s prediction of survival and (2) physician’s prediction of survival time with actual survival. Factors associated with accurate prognostic awareness were identified by univariate analysis. Results Of 133 patients eligible for inclusion in the study, 27 refused to discuss prognostic awareness and 49 answered “I don’t know.” Only 10 (17.5%) of the 57 patients surveyed had accurate prognostic awareness. Forty-three patients (75.4%) were optimistic about their prognosis; however, more than 80% of patients were more optimistic than their physicians about their prognosis. Conclusion A majority of the patients with advanced cancer in this study had prognostic awareness that was more optimistic in comparison with their actual survival, and most were more optimistic than their physicians about their prognosis. Further research is needed to develop programs to facilitate discussion of life expectancy with patients in a manner that is consistent with their preferences.
Functional and personal income distributions
Authors: Patrão Mauro , de Acypreste Rafael
Published: August 2022

The economic relations between functional income distribution and the three main personal income distributions --- total income, wealth, and wages --- are not straightforward in the economic literature. This paper presents an attempt to relate the factor shares and these personal income distributions in a more direct and precise manner. Our analytical result proves that the total income Lorenz curve is always above the weighted average of capital income and wages Lorenz curves, where the factor shares are the weights. We also establish a method to estimate income, wages, or wealth personal distributions when one of them does not exists.
Deciphering the link between membrane signaling and hub genes: bioinformatics prediction and experimental validation in colon cancer
Authors: Roy Ankan , . Niharika , Patra Samir Kumar
Published: August 2022

Visualization of complex topological assemblies and spatiotemporal epigenetic choreography of chromatin territory is emerging for better understanding gene expression. Colon cancer is one of the leading malignant neoplasms and there is still a paucity of information regarding colon cancer. Bioinformatics prediction and analyses helps to identify essential genes and significant pathways linked to the disease and to predict alternative strategies for curative measure. Colon cancer patient sample containing gene expression profile from three independent datasets, including GSE44076, GSE20916 and GSE37364 were downloaded from Gene Expression Omnibus (GEO) and thoroughly screened using the GEO2R tool and Funrich software to find out differentially expressed genes (DEGs) common from all three datasets. Other approaches, including Gene Ontology (GO) and KEGG pathway analysis, Protein-Protein Interaction (PPI) network construction and hub gene investigation, Overall Survival (OS) analysis, gene correlation analysis, methylation pattern analysis, and hub gene-Transcription factors regulatory network construction, were performed and validated using various bioinformatics tool. Initially, we identified 166 DEGs, including 68 up-regulated and 98 down-regulated genes. Up-regulated genes are mainly associated with the Cytokine-cytokine receptor interaction, IL-17 signaling pathway, Extracellular Matrix (ECM)-receptor interaction, Focal adhesion and PI3K-Akt pathway. Down-regulated genes are involved in metabolic pathways, retinol metabolism, Steroid hormone biosynthesis, and bile secretion. After analyzing the protein-protein interaction network, thirty hub genes with high connectivity are selected using the MCODE and cytoHubba plugin. Survival analysis, expression validation, correlation analysis, and methylation pattern analysis were further verified using TCGA data. Finally, we identified COL1A1, COL1A2, COL4A1, SPP1, SPARC, and THBS2 as potential gene hub related to ECM and presumably act as master regulators in colonic cancerogenesis. Moreover, our experimental data demonstrates that disruption of lipid raft and RAS/MAPK signaling cascade affects this gene hub at mRNA and protein level. We identified COL1A1, COL1A2, COL4A1, SPP1, SPARC, and THBS2 as determinant hub genes in colon cancer progression. These may be considered as novel biomarkers and could be targeted for therapeutic intervention. This work proofs for the first time that there is connecting link between membrane signaling hub and gene hub.
Clear cell carcinoma of salivary gland. Clinicpathologic study of 11 cases
Authors: Rocha Glauber Bareia Liberato , de Campos Wladimir Gushiken , Nunes³ Fabio Daumas , Saturno Juvani Lago , Lemos Celso Augusto , de Sousa Suzana Cantanhede Orsini Machado
Published: August 2022

Introduction. Clear cell carcinoma of salivary gland is a rare malignant neoplasm that accounts for less than 1% of salivary gland carcinomas. This term is common in many carcinomas with clear cells; however, it is more specific to hyalinizing clear cell carcinoma. Objective. This research aimed to evaluate histopathological, immunohistochemical, biomolecular, and clinical aspects of clear cell carcinomas of salivary gland cases diagnosed between 1997 and 2018. Materials and Methods. Histological sections, immunohistochemical reactions for cytokeratins 7 and 14 (CK7 and CK14), p63 protein, S-100 protein, and smooth muscle actin (SMA) were assessed, and real-time molecular polymerase chain reaction (RT-PCR) testing was performed to investigate the expression of the EWSR1-ATF1 fusion gene. Results. Eleven lesions with histological and immunohistochemical characteristics of clear cell carcinoma of salivary glands were found, 81.81% occurred in women, 77.77% in white people and the mean age was 56.42 years. The most affected regions were palate and buccal mucosa (36.36% of cases in each of these regions). Histologically, nine cases had hyalinization; neural invasion and necrosis were present in 6 and 2 of the cases, respectively. All cases were positive for periodic acid-Schiff (PAS) and expressed p63 protein and cytokeratins 7 and 14. In the PCR molecular test, 6 lesions showed EWSR1-ATF1 fusion gene. Conclusion. Clear cell carcinoma of salivary glands is more prevalent in women aged between 50 and 60 years. Histology associated with immunohistochemistry often closes the diagnosis. Molecular tests should be used as an aid in diagnosis.
Information Seeking Behavior on Covid-19 Vaccine among Residents of Fagge Local Government Area of Kano, Nigeria
Authors: Msughter Aondover Eric , AduaAdua Suleiman M. , Aondover Perpetua Ogechi
Published: August 2022

In Northern Nigeria, distrust jeopardizes the coronavirus response. On April 11, 2020, after World Health Organisation (WHO) declared the Covid-19 pandemic, Kano State confirmed its first positive Covid-19 case. In the same month, the state witnessed what was described as mysterious deaths, claiming hundreds of lives. Many people in the state believe that Covid-19 is a scam and a grand plot vaccine to reduce population and the government is using it to generate money, which made them rebuff the Covid-19 vaccine. In a state like Kano which was once the epicenter of the disease in Northern Nigeria, the resistance to the Covid-19 vaccine in the state pause a great danger in the fight against the Covid-19 pandemic. Within this context, this study examined information-seeking behavior on the Covid-19 vaccine among residents of the Fagge Local Government Area of Kano State. The study adopts the positivist approach of research design where a survey was used to generate data using a questionnaire. Simple random sampling was used to select the respondents using Taro Yamane’s formula to arrive at a sample size of 400. Based on the findings, the data indicates that social media constitute the major source of information for the Covid-19 vaccine in Fagge local government. The majority of the respondents in Fagge LGA are not satisfied with the information received on the Covid-19 vaccine. The data also indicates that the outcome of information-seeking behavior on the Covid-19 vaccine in Fagge LGA is significantly discouraging. The study concludes that the Health Believe Model can suitably be used and applied in the cases of contextualizing public behavior as regard to their information-seeking behavior using media messages towards the vaccine. This will greatly help in evaluating the implications of the public information-seeking behavior towards the Covid-19 vaccine.
Disturbances of natural and cultural landscape as an element of controversies in tourism – assessment based on the analysis of stress hormones in saliva
Authors: Godlewski Grzegorz , Kugiejko Magdalena , Charmas Małgorzata , Augustyniak Adam , Rybka Jakub
Published: August 2022

Context: The ecology of the natural and cultural landscape is an important decisive factor for tourists planning trips. The emerging disturbances of a landscape may affect not only the perception of tourist values, but also the health of visitors. Objectives: The aim of the study was to determine the relationships between identification of specific elements of a disturbed natural and cultural landscape and basic physiological reactions in study participants, namely the presence of stress hormones in saliva. The authors also intended to verify a new research method in the field of tourism and landscape assessment. Methods: The study participants were students. Samples of saliva were collected after displaying images. Hormone levels (cortisol, DHEA, testosterone) were determined using immunoenzymatic ELISA kits. Results: The results indicate that all respondents were in agreement as to which factors disturbed the landscapes presented. However, their subjective feelings were not reflected in a statistically significant manner in the physiological and biochemical reactions of their bodies. The authenticity of a landscape seems less important to the participants than expected. The lack of a strong reaction to a disturbed landscape is surprising, especially in the context of tourism, in which natural and cultural assets are some of the major factors affecting purchasing decisions and principal travel motives. Conclusions: This research may be a strong prognostic in the context of sustainable tourism and environment protection. This knowledge may be used by planners and spatial development experts in designing landscapes as well as in assessing the visitors'/tourists' perception of a landscape.
Novel aminophosphonate ligand for the preparation of catalytically active silica aerogels with finely dispersed palladium
Authors: Sipyagina Nataliya A. , Malkova Alena N. , Straumal Elena A. , Yurkova Lyudmila L. , Baranchikov Alexander E. , Ivanov Vladimir K. , Lermontov Sergey A.
Published: August 2022

Silica-based aerogels bearing a novel aminophosphonate-containing substituent were prepared. Pd+ 2 and Cu+ 2 ions were introduced into aerogel matrix to form chelated complexes with aminophosphonate moiety. Both complexes securely retain Me+ 2 after supercritical drying (SCD) in CO2. In silica matrix, Pd complex is reduced to metallic Pd after treatment by gaseous H2 at 120°C. In lyogel matrix, Pd complex can also be reduced to metallic Pd upon SCD in isopropanol. Pd-containing aerogel showed excellent catalytic activity in the reaction of C = C and C ≡ C bonds hydrogenation.
Serial volumetric analysis of meningioma after primary external beam radiation therapy and the factors predict the therapeutic response: a retrospective study
Authors: Kim Kyung Min , Kang Ho , Kim Min Sung , Kim Jin Wook , Lee Joo Ho , Park Chul-Kee , Kim Yong Hwy
Published: August 2022

Background: External beam radiation therapy (EBRT) is one of the treatment modalities for meningioma, and there are a few clinical reports about its short-term efficacy. However, studies reporting the long-term clinical outcomes with serial volumetric analysis are rare. This study reports the long-term clinical outcome of primary EBRT for meningioma with a comprehensive analysis of the volumetric changes and the annual reduction rate.Methods: A retrospective analysis was performed of patients who received conventional EBRT as a first-line treatment for meningioma between 1998 and 2020. The clinical outcomes and volumetric changes after primary EBRT were analyzed.Results: A total of 43 cases with a mean follow-up of 86.4 months were included. Most of the meningiomas were located in the skull base (40 cases, 93%). During the follow-up period, the tumor volume decreased in 38 (88.4%) patients and increased in 5 (11.6%) patients. The tumor volume generally decreased up to 6 months after EBRT, and transient volume expansion was observed between 6 and 12 months. When the tumor volume decreased 10% or more during the first 6 months after EBRT, a favorable therapeutic response was achieved. The mean overall reduction rate of tumor volume was 37.1%, and the mean annual reduction rate was 11.3%.Conclusions: Primary EBRT could be a feasible treatment option for meningioma from the perspective of volume control with favorable clinical outcomes.
Quantum Level Instability of Transverse Excitation in Electron Flow
Authors: Akbari-Moghanjoughi M.
Published: August 2022

In current research we use the effective Schrödinger-Poisson model to study a new kind of quantum level instability in an infinite-wall slab electron system. We use the Madelung fluid representation along with the conventional eigenvalue problem techniques in order to solve the linearized coupled differential equations representing the transverse collective linear excitations in the electron gas of arbitrary degree of degeneracy having a constant perpendicular momentum. It is shown that the energy levels of collective electrostatic excitations are doubly quantized due to coupled interactions between single-electron analogous to the classic problem of a particle in a box and collective Langmuir oscillations, which are modulated over single particle quantum state. We also report a new transverse electron slab current plasmon energy level instability caused by the interplay between the wave-like many-electron dispersion and the destabilizing perpendicular electron drift momentum. We further study in detail the parametric dependence of such instability versus different aspects of the quantum system. Such a quantum-level instability may have important applications in characteristic behavior the plasmonic devices and their frequency response. Parametric quantization of drifting electron fluid in a box may also have broad applications in nanoscale quantum device calibration and measurements.
Machine Learning-based Obesity Classification using 3D Body Scanner
Authors: Jeon Seungjin , Kim Minji , Yoon Jiwun , Lee Sangyong , Youm Sekyoung
Published: August 2022

Knowing one's obesity group is very important for healthcare. Obesity can cause various diseases; however, BMI, which is the currently popular standard for judging obesity, does not accurately classify the obese group. This is because BMI just reflects height and weight, ignoring the characteristics of body type. Therefore, we present the idea that reflecting the three-dimensional (3D) measurements of the human body can better classify the obese group than BMI. To prove this, we recruited a total of 160 subjects and collected 3D body scans, Dual-energy X-ray absorptiometry (DXA), and Bioelectrical Impedance Analysis (BIA) data pairwise. Through this, 3D body scan data could be expanded clinically. We proposed a machine learning-based obesity classification framework using 3D body scan data, validated it through Accuracy, Recall, Precision, and F1 score, and compared it with BMI and BIA. BMI had the following values: Accuracy: 0.529, Recall: 0.472, Precision: 0.458, and F1 score: 0.462 while BIA had the following values: Accuracy: 0.752, Recall: 0.742, Precision: 0.751, and F1 score: 0.739. Our proposed model had the following values: Accuracy: 0.800, Recall: 0.767, Precision: 0.842, and F1 score: 0.792 and our accuracy was 80%, which is higher than either BMI at 52.9% or BIA at 75.2%. Our model can be used for obesity management through 3D body scans.
Prediction skills of the CAMS-CSM Climate Forecast System on the South China Sea Summer Monsoon establishment
Authors: Han Tongxin , Wang Lijuan
Published: August 2022

Based on a set of hindcast experiments from 2011 to 2020, the prediction skills of the Chinese Academy of Meteorological Science Climate System Model (CAMS-CSM) climate forecast system on the features of abrupt change, characteristic process around the South China Sea (SCS) Summer Monsoon (SCSSM) establishment and the interannual variations are evaluated by using the ERA5 reanalysis and NOAA OLR data. The predictions are classified into three categories according to the length of lead time, that is, 1-30-, 31-60- and 61-90-day. Skillful prediction on the SCSSM onset pentad (pentads 27–28) are found at three lead times. The prediction skills decrease with the increasing lead times. Further investigation suggests that the transitions of the large-scale circulation around the SCSSM establishment at 200-hPa and 850-hPa can be well captured at three lead times. In the SCS, the transition times of the meridional temperature difference and zonal wind shear at 1-30-day lead time coincide with those of observation. The prediction skills on the characteristic process of the SCSSM onset, including the transition from easterly to westerly, the burst of convection, and the occurrence of rainfall over the SCS, are the best at 1-30-day lead time. The interannual variations of the SCSSM onset can only be reasonably reproduced at 1-30-day lead time. In addition, accurate predictions of the eastward retreat of the West Pacific subtropical high, the establishment of the trough in the Bay of Bengal, and the cyclone in the equatorial western Pacific are critical to the predictability of SCSSM onset.
Pooling Business Intelligence and Dashboard Technology for Decisions Making in Higher Education Institutions
Authors: Sharma Hemant , Joshi Hiren D
Published: August 2022

With the growing importance of information in organisational management and the advancement of information technology, there are now business application systems that assist companies and institutions in making more informed decisions and increasing high organisational efficiency. A company, for example, can use business intelligence, information, and environmental indicators to compare trends and forecast how they will change in the future. Today, business intelligence is one of the most important concepts for management and organisations seeking to lead in global markets and maximise the effectiveness of all of their business activities and processes. The management of a large volume of data can be a time-consuming task if the information is not properly classified and made available when needed. This is especially true in higher education, where massive amounts of data and analytics go unreported during each session. Universities collect a massive amount of data every year, from the time a student enrols to the time he or she completes a course. This data relates to admissions, student enrollment, courses, workshops, seminars, conferences, studios, attendance, financial resources, infrastructure development, and other topics. The most important responsibility is to compile data when this data needs to be expressed in an understandable format so that the Vice-Chancellor, Directors, Head of Department, Professor, and other high-ranking administrators can quickly understand the performance of ongoing tasks. Business Intelligence (BI) has developed dashboard technology that visualises trends and patterns, allowing for a more reliable and strategic approach. This paper discusses the significance of Business Intelligence (BI) and dashboard technology in higher education institutions (HEI). It is a data-driven, mission-updated, and student-centered BI dashboard that will not only keep decision-makers informed, but will also assist them in strategic planning and decision-making.
Synthesis of ultra-small NaA zeolite nanocrystals at near room temperature
Authors: Huang Yuhan , Li Min , Shi Chenxi , Liu Zhanjun , Ren Bo
Published: August 2022

The NaA zeolite nanocrystalline aggregates composed of 6 nm ultra-small were synthesized for the first time by refluxing at near room temperature and atmospheric pressure. NaA zeolite samples had been characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and N2 adsorption-desorption isotherms. The XRD of the obtained samples at different synthesis temperatures demonstrated that their crystallinity was high. Furthermore, the SEM images of NaA zeolite synthesized at 30, 40 and 60°C showed that its particle sizes were 100, 100 and 150 nm, respectively. Moreover, the TEM images confirmed that the NaA zeolite aggregates synthesized at 40°C and 60°C consisted of ultra-small crystals with a size of 6 nm, while the NaA zeolite synthesized at 30°C was a single crystal. Compared with the previously reported synthetic zeolite crystals, the use of a reflux system under atmospheric pressure in this study not only synthesized the ultra-small zeolite nanocrystals（6 nm）with large specific surface area, but also avoided many safety issues brought by traditional synthesis methods under high autogenous pressure. Therefore, this study provides a precise and safe synthetic method for the development of ultra-small zeolite nanocrystals.Moreover, the large specific surface area makes them have great potential for development.
Assessment of shoreline changes in the area of Karpen-Qerret-Golem, Durres
Authors: Nurce Bilbil
Published: August 2022

Albania's coastline has a length of about 450 km, with wide access to the Adriatic and Ionian seas, where various forms of sandy and rocky beaches are combined, with the possibility of touristic use. The study of shoreline changes is concentrated in the area of Karpen-Qerret-Golem, Durres, as the most frequented beach sector by locals and foreign tourists, as well as in the last three decades as very important area for the development of business in the field of construction. The purpose of the study is to compare the shorelines shown in the topographic maps of 1:10 000 scale (editions of 1978), on Ortophotos (1994, 2007, 2015, 2018) and 2021 GNSS measurements in the study area, as well determining the direction and rate of the shoreline changes. Since 1978, due to the shoreline erosion it lost over 810 000 m2, while the rise in sea level, caused by climate change, paints an even more shocking image for the future. Meanwhile fundings for scientific research in this field has been scarced in Albania, other countries have felt the impact of coastal erosion. The objectives of the study are: providing evidence of the shoreline changes in the area of Karpen-Qerret-Golem, as well as giving recommendations for stopping or reducing of shoreline erosion in this important sector.
Mutagenesis combined with fermentation optimization to enhance gibberellic acid GA3 yield in Fusarium fujikuroi
Authors: Li Ya-Wen , Yang Cai-Ling , Peng Hui , Nie Zhi-Kui , Shi Tianqiong , Huang He
Published: August 2022

Gibberellic acid (GA3) is a plant growth hormone that plays an important role in the production of crops, fruits and vegetables with a wide market share. Due to intrinsic advantages, liquid fermentation of Fusarium fujikuroi has become the sole method for industrial GA3 production, but the broader application of GA3 is hindered by the high production costs. In this study, we combined atmospheric and room-temperature plasma (ARTP) with ketoconazole-based screening to obtain the mutant strain 3-6-1 with high yield of GA3. Subsequently, the medium composition and fermentation parameters were systematically optimized to increase the titer of GA3, resulting in a 2.5-fold increase compared with the titer obtained under the initial conditions. Finally, considering that the strain is prone to substrate inhibition and glucose repression, a new strategy of fed-batch fermentation was adopted to increase the titer of GA3 to 575.13 mg/L, which was 13.86% higher than the control. The strategy of random mutagenesis combined with selection and fermentation optimization developed in this study provides a basis for subsequent research on the industrial production of GA3.
Integrative Multiomic Analyses of Diabetic Neuropathic Pain in Dorsal Root Ganglia: Proteomics, Phospho-proteomics, and Metabolomics
Authors: Doty Megan , Yun Sijung , Wang Yan , Hu Minghan , Cassidy Margaret , Hall Bradford , Kulkarni Ashok B.
Published: August 2022

Diabetic peripheral neuropathy (DPN) is characterized by spontaneous pain in the extremities. Incidence of DPN continues to rise with the global diabetes epidemic. However, there remains a lack of safe, effective analgesics to control this chronic painful condition. Dorsal root ganglia (DRG) contain soma of sensory neurons and modulate sensory signal transduction into the central nervous system. In this study, we aimed to gain a deeper understanding of changes in molecular pathways in the DRG of DPN patients with chronic pain. We recently reported transcriptomic changes in the DRG with DPN. Here, we expand upon those results with integrated metabolomic, proteomic, and phospho-proteomic analyses to compare the molecular profiles of DRG from DPN donors and DRG from control donors without diabetes or chronic pain. Our analyses identified decreases of select amino acids and phospholipid metabolites in the DRG from DPN donors, which are important for cellular maintenance. Additionally, our analyses revealed changes suggestive of extracellular matrix (ECM) remodeling and altered mRNA processing. These results reveal new insights into changes in the molecular profiles associated with DPN.
Patients and Family Caregivers’ Perceptions on Two Stress Reduction Interventions with Patients with Chronic Diabetic Foot Ulcers: A Qualitative Study
Authors: Pereira M.Graça , Pedras Susana , Louro André , Lopes Alberto , Vilaça Margarida
Published: August 2022

Background
The present study aimed to assess the perceptions of patients with chronic diabetic foot ulcers (DFUs) and their informal caregivers regarding the impact of two stress reduction interventions, such as a progressive muscle relaxation and hypnosis, on patients’ DFU and psychological wellbeing.
Methods
This multicenter study used a qualitative exploratory design and included individual interviews with eight patients with chronic DFUs and six family caregivers, using a semi-structured interview guide. Transcripts analysis employed thematic content analysis.
Results
Four key themes common to patients and their caregivers were found: 1) perspectives regarding the intervention; 2) intervention effectiveness; 3) the role of psychology on the DFU treatment; and 4) emotions and consequences associated with the DFU. Although themes were common to both treatment groups, sub-themes from the last two themes differed for patients that received muscle relaxation versus those who received hypnosis. One additional theme emerged from the caregiver’s interviews: 5) promotion of self care behaviors.
Conclusion
According to patients and caregivers, overall the two stress reduction interventions were beneficial for the DFU healing progression and emotional wellbeing. The hypnosis group also reported lasting effects. Participants suggested that psychological interventions such as stress reduction interventions could be included in the DFU standard treatment as an adjuvant to the clinical protocol for DFU treatment, preferably offered early on, when the patient begins treatment at the diabetic foot consultation.
Experimental Testing of Primary User Detection Using Decision Tree Algorithm With Software Defined Radio Testbed
Authors: Reddy B Siva Kumar , Deevi Nagesh
Published: August 2022

The concept of cognitive radio is a technology that uses radio spectrum resources to provide effective and efficient communication. The spectrum sensing function of this technology is very important in the performance of the network. One of the most common issues that the network encounters is the disruption brought on by the activity of secondary users. To avoid the interference caused by the traffic of secondary users, the network should adopt an efficient algorithm that can identify the presence of primary users. A decision tree is a classification method that can be used to determine the presence of these users. It has the advantages of high learning ability and fast processing speed. This paper presents a data collection method that uses a software defined radio to analyze the signal transmission in a real-time environment. The radio uses USRPN210 as hardware and is supported by the GNU Radio software.
Effect of stimulant medication on loss of control eating in youth with attention deficit/hyperactivity disorder: A prospective, observational case series study protocol
Authors: Keshen Aaron R. , Hilbert Anja , Taylor Victoria , Harris Anastasia L. , Trappenberg Nami , Sadek Joseph , Frank Guido K.W. , Murray Stuart B.
Published: August 2022

Background: Loss of control eating (LOC-E) in youth predicts the later development of full-syndrome binge-eating disorder (BED), and therefore, could be a relevant target for prevention treatments. To develop these treatments, it is important to understand the underlying disease processes and mechanisms. Based on the putative role of neurocognitive impairments in the pathogenesis of LOC-E, treatments that modulate these neurocognitive factors warrant further exploration. For instance, stimulants are an effective treatment for impulsivity in youth with attention deficit/hyperactivity disorder (ADHD) and have been shown to improve symptoms of BED in adults. Notably, stimulants have not been examined as a treatment for LOC-E in youth. To explore this gap, we aim to measure change in LOC-E episodes and secondary outcomes in youth with comorbid ADHD and LOC-E who are being started on stimulants. Methods: We will collect prospective observational data on forty 8-to-13-year-old youth diagnosed with comorbid ADHD and LOC-E who are initiating a stimulant for ADHD. Prior to stimulant initiation, participants will complete baseline measures including LOC-E episode frequency in the last 3 months (primary outcome), and secondary outcomes including disordered eating cognitions, emotions and behaviors, ADHD symptom severity, parental LOC-E, impulsivity and reward sensitivity, anxiety/mood severity. Outcome measurements will be gathered again at 3-months after initiating the stimulant. Within-patient standardized effect sizes with 95% confidence intervals will be calculated from baseline to 3-month follow-up for all outcomes. Discussion: Many individuals with LOC-E or binge eating do not fully remit over the course of psychotherapy. Whereas psychotherapy may address psychological and sociocultural domains associated with LOC-E, some individuals with neurocognitive impairments (e.g., ADHD) and neurobiological deficits (e.g., low intrasynaptic dopamine or norepinephrine) may benefit from adjunctive treatment that targets those factors. This will be the first study to provide pilot data for future studies that could examine both the effect of stimulants on LOC-E in youth and underlying mechanisms. Trial registration: Pending
Assessment of Geospatial analysis of soil properties using geostatistics models
Authors: Rao P. Smriti , Thomas Tarence , David Ashish
Published: August 2022

Accurate estimation of the spatial variability of soil properties is a critical component of agriculture ecosystem and environment modeling. The primary goal of this research is to determine soil characteristics and their spatial variability. The data was analysed for geographic variability using a combination of traditional analytical approaches and geostatistical methods. In October 2019, soil samples were taken from field through random sampling in Jagdalpur block of Bastar district, Chhattisgarh (India). Standard analytical procedures were used to assess pH, EC, Organic carbon, Iron, Nickel and Chromium in the soil. For direct envisaging of soil parameters, a conventional ordinary kriging (OK) interpolation was applied. Finally, by overlaying maps in a GIS context, the spatial distribution and correlation between OC and other soil parameters proclaimed.
Spin and Charge Drift-Diffusion in Ultra-Scaled MRAM Cells
Authors: Fiorentini Simone , Bendra Mario , Ender Johannes , de Orio Roberto Lacerda , Goes Wolfgang , Selberherr Siegfried , Sverdlov Viktor
Published: August 2022

Designing advanced single-digit shape-anisotropy MRAM cells requires an accurate evaluation of spin currents and torques in magnetic tunnel junctions (MTJs) with elongated free and reference layers. For this purpose, we extended the analysis approach successfully used in nanoscale metallic spin valves to MTJs by introducing proper boundary conditions for the spin currents at the tunnel barrier interfaces, and by employing a conductivity locally dependent on the angle between the magnetization vectors for the charge current. The experimentally measured voltage and angle dependencies of the torques acting on the free layer are thereby accurately reproduced. The switching behavior of ultra-scaled MRAM cells is in agreement with recent experiments on shape-anisotropy MTJs. Using our extended approach is absolutely essential to accurately capture the interplay of the Slonczewski and Zhang-Li torque contributions acting on a textured magnetization in composite free layers with the inclusion of several MgO barriers.
Identification and Genomic Characterization of a Novel HIV-1 Unique Recombinant Form (CRF01_AE/CRF07_BC) in Zhejiang Province, China
Authors: Fan Qin , Liu Jing , Chai Chengliang , Zhu Shuying , Fang Qionglou , Guo Zhihong , Xia Yan , Ding Xiaobei , Zhang Jiafeng
Published: August 2022

Mutation and recombination are important mechanisms leading to the frequent evolution and genetic diversity of HIV-1. In this study, we identified the near full-length genomic characterization of a novel HIV-1 unique recombinant form (URF) strain (Sample ID: ZJ20202195/ZJ/CHN/2020, hereafter referred to as ZJ20202195) isolated during the HIV-1 molecular surveillance in 2020 in Zhejiang Province, China, through different recombination analysis tools and phylogenetic analysis. Our results amply proved that the near full-length genome (NFLG) sequence of ZJ20202195 was a novel HIV-1 URF consisted CRF01_AE and CRF07_BC subtype, and delimited three recombinant segments, of which the Segment I (HXB2:776–5559 nucleotide (nt)) and Segment III (HXB2:6224–9412 nt) were mainly originated from CRF01_AE cluster g4a strains prevalent in China, and Segment II (HXB2:5560–6223 nt) was from CRF07_BC subtype. Overall, our findings provided insight and scientific basis into the genetic diversity and accurate determination of HIV-1 recombinant strains in China.