bluuebunny/crossref_metadata_2025 huggingface dataset:
Diquat Poisoning: Care Management and Medico-Legal Implications
Authors: Basilicata Pascale , Pieri Maria , Simonelli Angela , Capasso Emanuele , Casella Claudia , Noto Tina , Policino Fabio , Di Lorenzo Pierpaolo
Published: March 2022

Acute chemical intoxication represents one of the major causes of Emergency Room admittance, and possible errors in diagnosis are extremely frequent, especially when patients present generic and non-specific symptoms. Diquat, a bipyridyl class of herbicides, exerts high intrinsic toxicity as a consequence of free oxygen radicals, leading to cellular death and organ dysfunctions. Following ingestion, with the major source of absorption for suicidal purposes, the chemical induces local irritating effects; systemic symptoms appear later, while specific symptoms can occur in the following 48 h. A smoker and hypertensive 50-year-old man arrives at the E.R., reporting that an episode of herbicide inhalation occurred few hours earlier. Physical examination evidenced alkalosis with hypoxemia, leucocytosis, mild hyperglycaemia and moderate increase in creatine kinase and myoglobin. Despite blood creatine kinase and myoglobin values that were higher than normal, he was prescribed with hydration and anti-pain therapy. During the night, the man left the hospital; he returned the next morning at 8:45 a.m., with cardiorespiratory arrest, medium fixed non-reactive mydriasis, diffused cyanosis of the skin and of the mucous membranes, as well as imperceptible pulse and peripheral pressure. Despite resuscitation attempts, the patient died at 9:30 a.m.; the body was immediately transferred to the morgue. Autopsy and toxicological analyses were carried out nine days later, evidencing paraquat ingestion for suicidal purposes. GC/MS analyses to verify the presence of diquat were performed on body fluids and gastric and colon contents; all specimens resulted positive, thus confirming the cause of death as herbicide ingestion (blood diquat concentration of 1.2 mg/L; more than twice the minimum to observe a systemic poisoning). The procedure followed for patient management resulted to be not in line with the provisions of both guidelines and good clinical practices. Staff did not perform clinical-diagnostical monitoring of the patient’s condition or ask for more specific analyses (i.e., serum creatine phosphokinase monitoring). This misconduct led to a decrease in the patient’s chances to survive.
Free Cortisol Mediates Associations of Maternal Urinary Heavy Metals with Neonatal Anthropometric Measures: A Cross-Sectional Study
Authors: Choi Sohyeon , Lee Aram , Choi Gyuyeon , Moon Hyo-Bang , Kim Sungkyoon , Choi Kyungho , Park Jeongim
Published: March 2022

Prenatal exposure to heavy metals is known to be associated with adverse birth outcomes and oxidative stress biomarkers. In this study, we examined whether maternal free cortisol or 8-Hydroxy-2-Deoxyguanosine (8-OHdG) could mediate associations between maternal heavy metal exposure and birth outcomes. A total of 182 healthy pregnant women were recruited. Heavy metals (including Pb, Hg, and Cd), free-cortisol, and 8-OHdG were analyzed in urine at delivery. Birth outcomes including birth weight, length, Ponderal index, and head circumference were measured. To examine associations of maternal urinary heavy metals with biomarkers and birth outcomes, generalized linear models were employed. Birth length was positively associated with Pb (β = 0.78, 95% CI: 0.09–1.46) and Hg (β = 0.84, 95% CI: 0.23–1.45) (both p < 0.05). The Ponderal index, a measure of a newborn’s leanness, was negatively associated with maternal urinary Pb (β = −0.23, 95% CI: −0.46–−0.07) and Hg (β = −0.26, 95% CI: −0.44–−0.08) (both p < 0.05). No association between maternal Cd and birth outcomes was observed. Most heavy metals showed positive associations with free cortisol and 8-OHdG. Free cortisol was identified as a mediator underlying the observed relationship between Hg and birth length or Ponderal index. This study observed adverse birth outcomes from maternal exposures to Pb and Hg. Increased free cortisol related to Hg exposure was suggested as a possible causal pathway from Hg exposure to birth outcomes such as the Ponderal index.
Pandemic-Resilient Urban Centers: A New Way of Thinking for Industrial-Oriented Urbanization in Ethiopia
Authors: Mengistu Daniel Tesfaw , Gebremariam Ephrem , Wang Xingping , Zhao Shengbo
Published: March 2022

In Ethiopia, the flourishing of industrial parks in the suburbs of major urban centers is a recent phenomenon. The outbreak of COVID-19 has had an adverse impact on the emerging industrial parks and prospects of cluster cities. The aim of this article is to explore the different urban planning measures employed during the pandemic and to propose sound planning methods for the development of sustainable industrial-oriented urban centers. In Ethiopia, industrial-oriented urbanization started in the 1920s with the advent of the railway line. Currently, more than 25 industrial park-based cluster cities have flourished adjacent to cities. A number of initiatives have been undertaken by major stakeholders in these cluster cities to combat COVID-19. Their efforts, however, were made difficult because urban planners were not proactive and did not have foresight in the selection of sites that can mitigate the impact of COVID-19 or other similar pandemics. The researchers believe the problem could have been addressed if the planners used a science-based, human-focused, computer-aided decision-making approach, i.e., space syntax. Therefore, this article recommends that planners become proactive and work in collaboration with different stakeholders for the creation of resilient and livable industrial parks-oriented urban centers.
IFITM3 Interacts with the HBV/HDV Receptor NTCP and Modulates Virus Entry and Infection
Authors: Palatini Massimo , Müller Simon Franz , Kirstgen Michael , Leiting Silke , Lehmann Felix , Soppa Lena , Goldmann Nora , Müller Christin , Lowjaga Kira Alessandra Alicia Theresa , Alber Jörg , Ciarimboli Giuliano , Ziebuhr John , Glebe Dieter , Geyer Joachim
Published: March 2022

The Na+/taurocholate co-transporting polypeptide (NTCP, gene symbol SLC10A1) is both a physiological bile acid transporter and the high-affinity hepatic receptor for the hepatitis B and D viruses (HBV/HDV). Virus entry via endocytosis of the virus/NTCP complex involves co-factors, but this process is not fully understood. As part of the innate immunity, interferon-induced transmembrane proteins (IFITM) 1–3 have been characterized as virus entry-restricting factors for many viruses. The present study identified IFITM3 as a novel protein–protein interaction (PPI) partner of NTCP based on membrane yeast-two hybrid and co-immunoprecipitation experiments. Surprisingly, IFITM3 knockdown significantly reduced in vitro HBV infection rates of NTCP-expressing HuH7 cells and primary human hepatocytes (PHHs). In addition, HuH7-NTCP cells showed significantly lower HDV infection rates, whereas infection with influenza A virus was increased. HBV-derived myr-preS1 peptide binding to HuH7-NTCP cells was intact even under IFITM3 knockdown, suggesting that IFITM3-mediated HBV/HDV infection enhancement occurs in a step subsequent to the viral attachment to NTCP. In conclusion, IFITM3 was identified as a novel NTCP co-factor that significantly affects in vitro infection with HBV and HDV in NTCP-expressing hepatoma cells and PHHs. While there is clear evidence for a direct PPI between IFITM3 and NTCP, the specific mechanism by which this PPI facilitates the infection process remains to be identified in future studies.
Antibody and T Cell Responses against SARS-CoV-2 Elicited by the Third Dose of BBIBP-CorV (Sinopharm) and BNT162b2 (Pfizer-BioNTech) Vaccines Using a Homologous or Heterologous Booster Vaccination Strategy
Authors: Matula Zsolt , Gönczi Márton , Bekő Gabriella , Kádár Béla , Ajzner Éva , Uher Ferenc , Vályi-Nagy István
Published: March 2022

In the present study, antibody and T cell-mediated immune responses elicited by BBIBP-CorV and BNT162b2 vaccines were compared 6 months after the two-dose immunization of healthy individuals. Additionally, antibody and T cell responses after the third dose of BBIBP-CorV or BNT162b2 were compared using a homologous or heterologous vaccination strategy. The third dose was consistently administered 6 months after the second dose. Six months following the two-dose vaccination, the cumulative IFNγ-positive T cell response was almost identical in participants immunized with either two doses of BNT162b2 or BBIBP-CorV vaccines; however, significant differences were revealed regarding humoral immunity: the two-dose BNT162b2 vaccine maintained a significantly higher antireceptor-binding domain (RBD) IgG, anti-spike (S1/S2) IgG, and IgA antibody levels. The BNT162b2 + BNT162b2 + BBIBP-CorV vaccine series elicited significantly lower anti-RBD IgG and anti-S1/S2 IgG levels than three doses of BNT162b2, while the anti-S IgA level was equally negligible in both groups. Importantly, the cumulative IFNγ-positive T cell response was highly similar in both groups. Surprisingly, the BBIBP-CorV + BBIBP-CorV + BNT162b2 vaccination series provided a much higher cumulative IFNγ-positive T cell response than that elicited by three doses of BNT162b2; moreover, the levels of anti-RBD IgG and anti-S IgA were almost identical. Only the mean anti-S1/S2 IgG levels were higher after receiving three mRNA vaccines. Based on these data, we can conclude that administering a third dose of BNT162b2 after two doses of BBIBP-CorV is an effective strategy to significantly enhance both humoral and T cell-mediated immune response, and its effectiveness is comparable to that of three BNT162b2 vaccines.
Assessment of Changing the Abstraction and Recharge Rates on the Land Subsidence in the Nile Delta, Egypt
Authors: Abd-Elhamid Hany F. , Abd-Elkader Basant S. , Wahed Osama , Zeleňáková Martina , Abd-Elaty Ismail
Published: March 2022

The majority of residential, agricultural, and industrial areas are situated on cohesive soil in the Nile Delta, Egypt. Excessive pumping from the Nile Delta aquifer to meet the increasing demands for water could lead to aquifer system compaction and land subsidence. Land subsidence endangers infrastructure such as buildings, bridges, canals, and roads, as well as deteriorating lands and agricultural resources. The objective of this research is to investigate the land subsidence and predict the future behavior of the middle Nile Delta. The study goals are met by using a numerical model (MODFLOW) to simulate groundwater flow and an analytical solution to calculate land subsidence conditions. In this study, three scenarios are considered including; decreasing aquifer recharge, increasing abstraction and combination of the two. The results reveal that decreasing recharge by 94.4%, 88.8%, and 83.2% led to 30-, 60-, and 90-mm land subsidence, respectively, while increasing abstraction by 146%, 193%, and 233% led to land subsidence by 190, 380, and 560 mm, respectively, in the Nile delta. However, the combination of the two scenarios led to 220-, 440-, and 650-mm land subsidence. According to the results the future land subsidence due to over pumping from the Nile Delta should be considered in the future development plans of the country which intend to increase the abstraction from the Nile Delta aquifer. Increasing abstraction could increase the land subsidence that may cause many damages in different properties.
Cooperation Enhances Adaptation to Environmental Uncertainty: Evidence from Irrigation Behavioral Experiments in South China
Authors: Heinz Sebastian , Otto Ilona M. , Tan Rong , Jin Yingyi , Glebe Thilo W.
Published: March 2022

The world currently faces an unprecedented phase of global environmental change largely driven by the combined impact of anthropogenic climate change and environmental degradation. Adaptation to global environmental changes in natural resource management is often hindered by high levels of uncertainty related to environmental impact projections. Management strategies and policies to support adaptation measures and sustainable resource management under substantial environmental uncertainty are thus urgently needed. The paper reports results of behavioral irrigation experiments with farmers and students in the region of Hangzhou in China. The experimental design simulates a small-scale irrigation system with five parties located along an irrigation channel. The first treatment adds weather variability with a drying tendency that influences water availability in the irrigation channel. In the second treatment, the participants can select one of two adaptation options. Our results suggest that participants react with a marked delay to weather uncertainty. In addition, upstream players are more likely to adapt to uncertainty than those further downstream, and groups who show higher levels of cooperation more frequently invest in adaptation measures. Lastly, extraction inequality in earlier stages is found to constitute a key obstacle to collective adaptation.
Recent Advances in Autotrophic Biological Nitrogen Removal for Low Carbon Wastewater: A Review
Authors: Zhang Quan , Xu Xijun , Zhou Xu , Chen Chuan
Published: March 2022

Due to carbon source dependence, conventional biological nitrogen removal (BNR) processes based on heterotrophic denitrification are suffering from great bottlenecks. The autotrophic BNR process represented by sulfur-driven autotrophic denitrification (SDAD) and anaerobic ammonium oxidation (anammox) provides a viable alternative for addressing low carbon wastewater. Whether for low carbon municipal wastewater or industrial wastewater with high nitrogen, the SDAD and anammox process can be suitably positioned accordingly. Herein, the recent advances and challenges to autotrophic BNR process guided by SDAD and anammox are systematically reviewed. Specifically, the present applications and crucial operation factors were discussed in detail. Besides, the microscopic interpretation of the process was deepened in the viewpoint of functional microbial species and their physiological characteristics. Furthermore, the current limitations and some future research priorities over the applications were identified and discussed from multiple perspectives. The obtained knowledge would provide insights into the application and optimization of the autotrophic BNR process, which will contribute to the establishment of a new generation of efficient and energy-saving wastewater nitrogen removal systems.
Development of a New Dolomite-Based Adsorbent with Phosphorus and the Adsorption Characteristics of Arsenic (III) in an Aqueous Solution
Authors: Khashbaatar Zoltuya , Akama Shota , Kano Naoki , Kim Hee-Joon
Published: March 2022

In recent decades, the removal of hazardous chemicals that have entered wastewater and groundwater as a result of industrial and consumer activities has become an issue of concern. Specifically, removing arsenic (III) from groundwater is critical and equally crucial in the use of low-cost, efficient adsorbent materials. One purpose of this study was to develop a low-cost hydroxyapatite adsorbent (Ca5(PO4)3OH) by reacting the Ca component of calcined dolomite with phosphorus, and another was to apply the developed adsorbent to remove arsenic (III) from well water in developing countries. In this study, phosphorus adsorption was performed on thermally calcined dolomite, and the adsorption isotherm of the phosphorus study was investigated on selected calcined dolomite. The maximum amount of phosphorus on the selected calcined dolomite was 194.03 mg-P/g, and the Langmuir isotherm model was fitted. Arsenic (III) adsorption was investigated in a wide pH range (pH 2~12) using the new adsorbent. The amount of arsenic (III) adsorbed was 4.3 mg/g. The new absorbent could be effective in removing arsenic (III) and become an affordable material.
Adaptation Potential of Three Psychrotolerant Aquatic Bacteria in the Pan-Okhotsk Region
Authors: Voronina Olga L. , Kunda Marina S. , Ryzhova Natalia N. , Aksenova Ekaterina I. , Novikova Olga D. , Gintsburg Alexander L.
Published: March 2022

The Pan-Okhotsk region, which is part of the western North Pacific Ocean, is famous for its active volcanoes, which are part of the Pacific Ring of Fire and that enrich the surrounding waters with essential chemicals. Therefore, this region, including the Sea of Okhotsk and the Sea of Japan, is characterized by rich biota. Bacterioplankton plays a significant part in biological communities and is an indicator of ecosystem function. Analyzing the adaptability of three representatives of the microbiota of the Pan-Okhotsk region was the goal of our investigation. Marinomonas primoryensis KMM3633T (MP), Yersinia ruckeri KMM821 (YR), and Yersinia pseudotuberculosis 598 (YP) from the G.B. Elyakov Pacific Institute of Bioorganic Chemistry were studied by means of genomic and bioinformatic methods. The list of membrane translocator proteins, metabolism pathways, and cold shock and antifreeze proteins that were revealed in the genome of MP characterized this bacterium as being adaptable to free living in marine conditions, even at winter temperatures. The genomic potential of YR and YP makes not only survival in the environment of the Pan-Okhotsk region but also pathogenesis in eukaryotic organisms possible. The data obtained will serve as a basis for further ecosystem monitoring with the help of microbiota research.
Los tratados de doble imposición tributaria y su efecto en la inversión extranjera directa en Colombia
Authors: Castellanos Polo Orlando Carmelo , Pérez Barrios Edgar Estuardo
Published: March 2022

Este artículo estuvo orientado en una revisión sistemática sobre la inversión extranjera directa de los convenios de la Doble Tributación Internacional en Colombia. Puesto que los convenios tributarios permiten un equilibrio económico y fiscal, lo que se refleja en el aumento de la inversión directa extranjera. Se utilizó el muestreo simple de la inversión impositiva desde el período 2007 al 2009, conforme a la ejecución en materia tributaria. Con esto se determinó la importancia de los tratados de doble imposición tributaria para la economía de los países, los resultados de la investigación exponen que a mayor número de convenios suscritos de doble tributación internacional éste favorece positivamente la economía del país, generando mayor inversión directa extranjera.
Entrepreneurial Marketing and Organizational Entrepreneurship Performance of Small and Medium Enterprises: A Systematic Review
Authors: Shahmohammadi Batoul
Published: March 2022

Objective: The purpose of this article was to systematically review the existing articles on entrepreneurial marketing and organizational entrepreneurship of small and medium enterprises. Research Design & Methods: For this purpose, English research related to the keywords entrepreneurial marketing, impact, organizational entrepreneurship and small and medium enterprises were searched in Elsevier, Emerald and Springer databases for the period 2018-2021. In the meantime, 12 related articles were extracted and studied. Findings: The results of this study showed that the dimensions of entrepreneurial marketing improve organizational entrepreneurship indicators in small and medium enterprises. Implications & Recommendations: Entrepreneurial marketing is one of the marketing strategies of small and medium enterprises that helps them grow through entrepreneurship. In fact, entrepreneurial marketing translates important aspects of marketing and entrepreneurship into a comprehensive conceptualization in which marketing becomes the method that firms use to do entrepreneurship. Contribution & Value Added: This article reviewed 12 most recent published articles in terms of entrepreneurial marketing and organizational entrepreneurship to pave the way of finding latest information in this regard.
“Spot On & Off”: Evaluation of Effectiveness of Self-Formulated Menstrual Hygiene Campaign in Rural India
Authors: Aggarwal Anshi
Published: March 2022

Menstruation is a phenomenon unique to girls. However, i t has always been surrounded by taboos that lead to the exclusion of women from many spheres of life. In rural India, the topic is still taboo. One of the biggest challenges that women face is not being educated and not having the resources to get sanitary pads. The present research study aims to evaluate the effectiveness of a self-formulated campaign called “Spot On & Off” to raise awareness about menstrual hygiene among females belonging to three different age groups 8-15, 16-35, 36-60, with most of the girls from the age group 16-35. They live in the rural area of Mewat in Haryana, India. A survey was conducted with 300 female respondents. Post the survey, an awareness workshop was carried out, where videos of gynaecologists explaining what menstruation is, was shown. A post-survey was conducted to assess the effectiveness of the campaign. The respondents’ awareness showed a significant increase from 2.19 to 5.54 out of 10 on average. The study also found out that awareness had a 19% impact on the liking of reusable pads. Evidently, campaigns can exert a large impact on awareness in rural villages. Therefore, organisations need to start working at the grassroots level and reach out to more females in rural communities.
Women’s Perception of Air Pollution and Associated Health Hazard Aspects – A Study in Low- Income Urban Space in Bangladesh
Authors: Hena Aziza , Jahan Sharmin , Sujana Sabrina Nasrin , Siddique Sheikh Nayem
Published: March 2022

This paper explores women’s perception of air pollution and associated health hazards they experience in the low-income urban community of Bangladesh. Following the qualitative methodology, the research employs primary and secondary data to scrutinize the linkage between air pollution and women’s health. Data analysis in both percentages and an interpretive thematic approach was supported by two focus group discussions and 15 in-depth interviews conducted in the Mridhabari area in Matuail– one of the environmentally vulnerable areas in urban Bangladesh. The findings show that poor women’s comprehension of emissions of greenhouse gases and air pollutants is unsound and erroneous. Though women suffer from multiple physical, psychological, and reproductive health sicknesses due to their stay in a place with poor air quality, their apathetic outlook on health, reinforced by socially accepted gender norms, ignorance, misconception, and blind faith, contributes to avoiding seeking any medical treatment while getting sick. The sense of care and altruism drives them towards considering medical treatment for the dependent members of the household when they overlook the idea of spending on their health until and unless they suffer an illness with acute phase.
Gratitude (Kebersyukuran) dan Psychological Well-Being Remaja Panti Asuhan Rahmatan Lil’alamiin
Authors: Ade Frihapma Semita , Irdam  , Riyanda Hafizatul Fitria
Published: March 2022

Living in an orphanage is a condition that is not expected by all teenagers, but there are some teenagers who have to live in an orphanage due to various factors. Life in an orphanage is also very complex with various problems that occur, especially for teenagers who enter the musical period and are still unstable. Psychological well-being with the gratitude (gratitude) they have is an important thing to see in adolescents. This study aims to determine the relationship between gratitude (gratitude) and psychological well-being in adolescents at the Rahmatan Lil' Alamin Orphanage, Padang City. The independent variable in this study is gratitude (gratitude) while the other variable is psychological well-being. The measuring instrument used in this study is a scale of gratitude (gratitude) and psychological well-being. The sampling technique in this study used a saturated sampling technique. The sample in this study was 60 teenagers at the Rahmatan Lil 'Alamin Orphanage, Padang City. Test the validity and reliability in this study using the Alpha Cronbach technique. The results of the validity coefficient on the gratitude scale move from rix = 0.479 to rix = 0.913 with a reliability coefficient of = 0.973 while the results of the validity coefficient on the psychological well-being scale move from rix = 0.349 to rix = 0.767 with a reliability coefficient = 0.926 . Based on data analysis, obtained a value of 0.629 with a significance level of 0.000 which means the hypothesis is accepted. Research shows that there is a significant relationship between gratitude (gratitude) and psychological well-being in adolescents at the Rahmatan Lil 'Alamin Orphanage, Padang City
Digitalisasi sistem monitoring sampah rumahan berbasis Internet of Things
Authors: Nur Pasha Mochamad Sonda , Supriyadi Tata , Hanifatunnisa Rifa
Published: March 2022

ABSTRAK
Pengelolaan sampah yang baik menjadi salah satu faktor yang mempengaruhi terciptanya lingkungan bersih dan sehat. Disamping itu, dikala pandemi Covid-19 ini banyak sekali masyarakat menjadi korban salah satunya adalah berkurangnya mata pencaharian dan kehilangan pekerjaan. Penelitian ini bertujuan untuk membuat digitalisasi sistem monitoring sampah rumahan berbasis Internet of Things (IoT) yang dapat mencegah terjadinya tempat sampah overload dan menjadikan sampah bernilai ekonomis sehingga menjadi mata pencaharian tambahan bagi masyarakat. Perancangan sistem ini menggunakan modul mikrokontroler Arduino Mega, sensor infrared, sensor induktif proximity, modul HX711, sensor load cell, dan NodeMCU untuk mengirim data melalui local server. Hasil dari alat yang dimana sensor loadcell untuk sampah logam memiliki rata-rata kesalalahan sebesar 2,89% dan rata-rata selisih dengan timbangan konvensional sebesar 0,83 gram, sedangkan sensor load cell untuk sampah non logam memiliki rata-rata kesalahan sebesar 2,47% dengan rata-rata selisih berat dengan timbangan konvensional sebesar 0,9 gram. Pengujian pada perangkat lunak dan perangkat keras dapat beroperasi dengan baik dan sesuai dengan perencanaan sehingga data pengujian dari perangkat keras dapat didokumentasikan di perangkat lunak secara digital.
Making “gluten free” cauliflower (Brassica oleracea var. botrytis L.) flour to make tortillas with linaza (Linum usitatissimum) and chía (Salvia hispánica)
Authors: RODRIGUEZ-CHAVEZ Kristell Amairany , SANTIESTEBAN-LÓPEZ Norma Angélica , CERÓN-CARRILLO Teresa Gladys , MALDONADO-RESÉNDIZ Jorge Ángel
Published: March 2022

The current interest in the ketogenic diet provides the industry with the opportunity to develop new and better products, such as gluten-free foods for celiac patients and low-carbohydrate foods for overweight people, which in turn help prevent diseases that this provocative suffering. The tortilla is a globalized food in the daily diet, which makes it possible to add alternative ingredients. The objective of this work was to make cauliflower flour to make tortillas with flaxseed and chia with low carbohydrate content to verify if it is feasible as a daily food for those suffering from celiac disease, incorporate them into the ketogenic diet and in turn prevent the diseases caused by being overweight. For this purpose, tortillas with a diameter of 12 cm. and a thickness of 1 mm. were made with 50% cauliflower flour, 25% powdered chia and 25% powdered flaxseed.
PLA2A gene from Arabidopsis thaliana in response to infection by Ustilago maydis
Authors: CASARRUBIAS-CASTILLO Kena , ZAÑUDO-HERNÁNDEZ Julia , MÉNDEZ-MORÁN Lucila
Published: March 2022

In this work, U. maydis-Arabidopsis pathosystem was used to evaluate the PLP2A Arabidopsis gene roll in response to U. maydis infection. For this, both wild-type and pla2a mutant plants were inoculated with a haploid strain of U. maydis, and the progress of the infection was followed, results show that transcript plays an important role in the establishment of the infection being evident in the mutant plant compared to wild-type plants. On the other hand, the orthologous gene was found in corn, the natural host of U. maydis, with 69% identity to the AtPLA2A gene. The PLP2A gene expression was analyzed by RT-PCR assays and the results showed that this gene is induced from the first day after inoculation, the transcript increases as the infection progresses; this supports the theory that the transcript AtPLA2A is involved in the mechanisms of resistance and susceptibility to the pathogen. The use of Arabidopsis has made it possible to understand the defense responses in the plant and the pathogenic process of U. maydis, therefore, the results obtained can clarify the role of PLA2A in a comparative and integrative way in host and non-host plants of U. maydis.
Interdisciplinary collaboration among the fields of social care, health care and education in higher education: An integrative review
Authors: Tuominen Miia , Salminen Jaanet , Raukola-Lindblom Marjaana , Huhtasalo Jenni
Published: March 2022

One key question in higher education is how it can produce relevant work life outcomes. The significance of interprofessional collaboration in the fields of social care (S), health care (H) and education (E) has been clearly identified, but there is a lack of research regarding the collaboration of these disciplines in higher education. This integrative literature review explores what education-related interdisciplinary collaboration exists among the SHE disciplines in higher education. This review is the first attempt to synthesise this knowledge. The collaboration among the SHE disciplines in higher education is implemented in arranging, evaluating and developing interprofessional education, and with work life; however, this collaboration is rare. When it exists, it does not inclusively bring together faculty members and work life. The higher education of SHE disciplines need to be planned, conducted and evaluated in interdisciplinary collaboration to better correspond to genuine interprofessional work life situations.
Company Values of Malaysian Listed Companies' Sustainability for Palm Oil Industry: Financial Panel Data Model Approach
Authors: Khin Aye Aye , Khai Kho Guan , Chiek Aik Nai
Published: March 2022

Objective - "Sustainability" meanings are many different things, e.g. food security, food safety, and economic growth short-tern survival of the production which included social, environmental, economic, based on the institutional objectives. This study aimed to conduct the sustainability of the palm oil industry in Malaysia using the financial panel data model approach. Methodology/Technique - The sampling data were obtained from 2014 to 2018 for 30 listed companies with a total of 150 observations. The research findings are helpful for palm oil production companies and also the major export products in Malaysia. Findings - In recent times, there have been many accusations about the palm oil industry in Malaysia due to the environmentally unfriendly product mentioned by the European Parliament and thus, they decided to ban palm oil biofuel by 2020. This would have a negative impact on the palm oil production companies and it is reflected in the company's share price (company value) of the companies. The paper highlights the level of environmental accounting (EA), environmental performance (EP), and information disclosure (ID), how to affect the company value (CV) for the sustainability of palm oil production companies. Novelty - The novelty of this paper is reflected that as one of the national priority areas (NPAs) of the county and create decent work and economic growth (goal 8), increase industry, innovation, and infrastructure (goal 9), and influence responsible consumption and production (goal 12) for sustainable development goals in Malaysia, respectively. Type of Paper - Empirical. Keywords: Company value; Sustainability; Palm oil production; Forecasting; Panel data model; Listed companies in Malaysia JEL Classification: C330, D2, G, Q1.
The Effect of Investment Risk, Macroeconomics on Stock Prices in IPO Companies during the Covid-19 Pandemic
Authors: Supriyanto Supriyanto , Alexandri Mohammad Benny , Novel Nurillah Jamil Achmawati
Published: March 2022

Objective - This study investigates the effect of investment risk, macroeconomics on stock prices in IPO companies during the Covid-19 pandemic.

Methodology/Technique - Financial statements are used to collect sample secondary data. A total of 74 samples from data collection were then used to test hypotheses using SmartPLS software.

Findings - The results showed that the Current Assets to Total Assets Ratio (CATAR) and PBV (Price to Book Value) are still new topics that provide great benefits for investing in IPO companies.

Novelty - This study adds to the body of knowledge on investment risk and macroeconomics by elucidating the effect of investment on stock prices. Additionally, it provides an overview of the sources of information that can be used to inform investment decisions and to anticipate misinformation received, allowing investors to earn more money with less risk.

Type of Paper - Empirical.

Keywords: Investment Risk; Macroeconomics; Stock Prices; Covid-19

JEL Classification: G31, E02, E31, E60
THE ROLE OF COGNITIVE BIASES, EMOTION AND PSYCHOLOGICAL MANAGEMENT DETERMINANTS ON INNOVATION DEVELOPMENT AND ENTREPRENEURIAL ORIENTATION: AN EVIDENCE OF SMALL AND MEDIUM MANUFACTURING ENTERPRISES
Authors: Soonthonsmai Vuttichat
Published: March 2022

The importance of innovation is well acknowledged in the literature of management. Innovation not only brings competitive advantages to organizations but also, along with science and technology, is the essential assets of nations seeking to secure economic competitiveness with the entrepreneurship sphere. The purposes of this study were to examine and investigate the relationships between cognitive biases, emotions on innovation, share-practiced, trust-based relations, and norms in venture creation with innovation development and entrepreneurial orientation. Survey research was conducted. The study found that such variables as cognitive biases, emotions on innovation, share-practiced, trust-based relations, norms, and innovation development correlated positively with innovation development and entrepreneurial orientation. Results suggested cognitive biases and emotions on innovation as a mechanism that triggers innovation development and that this effect is stronger when they engage in opportunity-based entrepreneurship. Finally, pragmatic implications were discussed on how to utilize these factors to gain competitiveness and sustainability.
THE IMPLEMENTATION OF EMPLOYEE ASSISTANCE PROGRAM IN MALAYSIA, THE UNITED KINGDOM AND AUSTRALIA IN DEALING WITH MENTAL HEALTH ISSUES AT WORKPLACE: AN OVERVIEW
Authors: Azmi Ruzita , Ahmad Siti Nur Samawati , Mustafa Kamil Bidayatul Akmal , Mohd Zaki Nurul Shafiqah Akma
Published: March 2022

Workers are currently struggling to cope with assigned tasks. As the workload increases and improperly managed, workers are certainly exposed to work-related stress, which will not only affect their performance, but also their mental health. Employers may implement Employee Assistance Program (EAP) that offers counselling sessions, workshops, support group and others, as a preventive and proactive measure to help their employees to overcome issues associated with work-related stress. Nevertheless, EAP is subject to limitations in terms of its effectiveness, such as its implementation is not optimized by organisations adapting it, and less effective EAP sessions that barely resulted in improvement of workers' mental health. Malaysian law does not stipulate the implementation of EAP in organizations. However, Section 15 (2) of the Occupational Safety and Health Act 1994 impliedly supports the introduction of EAP in Malaysia. The purpose of this paper is therefore to explain how employers in Malaysia should implement EAP to help their workers’ mental health well-being, as well as to compare how EAP is implemented in the United Kingdom and Australia. This paper applies qualitative method, which consist of doctrinal legal research approach to understand the program dealing with mental health. Comparative method will also be employed in order to compare the legal frameworks and programs related to mental health well-being in the developed countries such as the United Kingdom and Australia and this involves examination of the similarities and dissimilarities between situations within the same legal system. This paper concludes that the implementation of EAP in an organization will be able to promote the mental health well being of employees.
HYBRID THEATRE: PERFORMING TECHNIQUES IN THE EFFORTS TO PRESERVE THE ART OF THEATRE PERFORMANCE POST COVID19
Authors: Hussin Andika Aziz , Bianus Addley Bromeo
Published: March 2022

The pandemic of COVID19 and the Movement Control Order (MCO) has opened up the minds of local theatre players to be more creative in applying the suitable medium in showcasing their creative performances. Thus, emerged various forms of virtual theatre known as `online theatre’. No one ever imagined that theatre performances would be performed online but now, it is a practical approach in ensuring the sustainability of the theatre art itself. However, various questions arose about online theatre in Malaysia, such as confusion with the understanding of the terms, forms, and concepts of the performance. This study and writing are based on the online theatre performance ~Sel Akhir’ by the Seni Ceritera Association and King Lear by the KL Shakespeare Players (KLSP). Based on Aristotle's Dramatic Elements approach, the authors used observation and comparison methods to explain the approach used by these two presentations and propose to our Malaysian theatre players a method of online performance that suits the current capabilities and requirements, known as hybrid theatre.
Clinical Translation of Gold Nanoparticles into Effective Neuromedicines: Bottlenecks & Future Prospects
Authors: Mishra N T Pramathesh , Yadav Shalini , Khantwal Mayank , Khan Wasim , Khan Salman
Published: March 2022

Nanotechnology is the most interesting and advance area of research field in the current date. Nanoparticles are defined as a substance whose particle size varies between 1-100nm.This review focus on the potential of gold nanoparticlesto be used as an alternative to available neuromedicines due to their various unique properties. This paper also deals with advantages of gold nanoparticlesover available neuromedicines along with various bottlenecks in the translation of gold nanoparticles into effective neuromedicinesand the future perspective or scope of gold nanoparticles to be used as neuromedicines.©2022iGlobal Research and PublishingFoundation. All rights reserved.
Lung Cancer: How Well We Have Fared?
Authors: S. Patil Pradeep , S. Mahajan Hitendra
Published: March 2022

Lung Cancer has been one of the most common causes of death worldwide. With the death toll increasing in millions every year globally it has become a global scourge. With poor prognosis and disappointing 5 years survival rate post diagnosis, treatment for this disease has been ambiguous. Various advances in treatment are being made but till date the 5 years survival for major patients remains a dream. This review encompasses different treatment options that are available, problems associated with treatment and future perspective for the treatment of lung cancer. ©2022iGlobal Research and PublishingFoundation. All rights reserved.
In vitroCytotoxic Activity of a Sulphated Polysaccharide Ulvan against Human Breast and Glioblastoma Cell line
Authors: Sonia K. , Meena K.S. , Bai S. Alamelu
Published: March 2022

This study was designed to evaluate the hemolysis, anti-inflammatoryand cytotoxicityactivity of sulphated polysaccharideulvan extracted from greenseaweed Ulvalactuca(UL).Ulvan was extracted and characterized with UV-Visible Spectroscopy, Fourier transform infraredspectroscopy (FTIR) and Scanning electron microscopy(SEM).Total uronic acid and sulphate content were found to be 19.38% w/w and 22.53% w/w.The biocompatibilityof the sulphated polysaccharide ulvan wasevaluatedviahemolysis, its interaction with erythrocyte structure and anti-inflammatory studies.Further,thepolysaccharide was treated for cellular toxicityagainsthuman breast cancer(MCF-7)and human glioblastoma cancer (U87) cell linesusing the 3-(4, 5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) assaymethod.This study indicates that the sulphated polysaccharide ulvanwas more suitable for biomedical applications with promising chemo preventive and chemotherapeutic activity.©2022iGlobal Research and PublishingFoundation. All rights reserved.Cite this article as:Sonia, K.; Meena, K.S.; Alamelu Bai, S.In vitro Cytotoxic Activity of a Sulphated Polysaccharide Ulvan against Human Breast and Glioblastoma Cell line.Indo Global J. Pharm. Sci., 2022; 12:122-127. DOI:http://doi.org/10.35652/IGJPS.2022.12012.
Efektivitas Peraturan Direktur Jenderal Bimbingan Masyarakat Islam Nomor: DJ.II/542 Tahun 2013 Terhadap Pencegahan Disorganisasi Keluarga di KUA Kecamatan Bondowoso Kabupaten Bondowoso
Authors: Alfiah Siti
Published: March 2022

Proses pudar atau melemahnya norma agama dalam masyarakat karena adanya perubahan yang mengakibatkan perpecahan keluarga. KUA memberikan pelayanan dalam bentuk kursus calon pengantin. Sehingga terbitlah Peraturan Direktur Jenderal Bimbingan Masyarakat Islam Nomor: DJ.II/542 Tahun 2013 tentang Kursus Calon Pengantin, yang sekarang telah berubah nama menjadi Bimbingan Perkawinan. Peraturan ini bertujuan untuk mewujudkan keluarga yang baik serta dapat meminimalisir angka disorganisasi keluarga. Jenis penelitian ini adalah penelitian lapangan yang dikategorikan penelitian yuridis empiris kualitatif. Penelitian ini menggunakan pendekatan kasus (case approach) di KUA Kecamatan Kota Bondowoso Kabupaten Bondowoso. Hasil dari penelitian ini adalah bimbingan perkawinan dan kursus calon pengantin terdapat perbedaan dari segi pesertanya. Peserta bimbingan perkawinan dibagi menjadi dua, yakni calon pasangan suami istri dan masuk usia menikah. Faktor penghambat dan faktor pendukung berasal dari faktor internal maupun eksternal. Dalam penerapan Peraturan Direktur Jenderal Bimbingan Masyarakat Islam Nomor DJ.II/542 Tahun 2013 tentang Penyelenggaraan Kursus Pra nikah terdapat korelasi antara filsafat hukum dan sosiologi hukum. Maka, hal inilah yang melatarbelakangi efektivitas bimbingan perkawinan di KUA Kecamatan Kota Bondowoso dapat meminimalisir angka disorganisasi keluarga dengan baik.
Implementasi Pasal 34 Ayat 1 UUD 1945 Tentang Perlindungan Anak Terlantar di Dinas Sosial Kabupaten Jember
Authors: Nisah Hoirun , Hamam Hamam
Published: March 2022

In recent years, the attention of the government and the public on children's lives has increased. The growth and development of community organizations engaged in child protection is one of the evidences of the high level of humanitarian feelings that exist in society. But behind it all, the concern of the government and the community is not in accordance with the current situation where more and more children are being neglected, hunting for minors, violence against children and so on. Looking at the existing laws, the realization of Article 34 paragraph 1 of the 1945 Constitution has not been maximally implemented, it is necessary to carry out serious research on the implementation of Article 34 Paragraph 1 of the 1945 Constitution. Abandoned Children Are Cared for by the State at the Social Service of Jember Regency. The focus of this research is 1) How is the implementation of the 1945 Constitution article 34 paragraph 1 of neglected children in Jember district? While the purpose of this study is to determine the implementation of the 1945 Constitution article 34 paragraph 1 of neglected children in Jember district & to find out the legal protection of neglected children in Jember, where Jember as a district cares about human rights. The approach used in this research is a qualitative approach, qualitative research methods are often referred to as naturalistic research methods, because the research is carried out in natural conditions. The type of research is a case study, where a case study is a contemporary empirical investigation in a context that is not so clear. The case study design was chosen to help researchers determine the implementation of legal protection for neglected children in Jember Regency.
Analisis Transaksi Jasa Joki Rank Mobile Legend Melalui Sosial Media Perspektif Fatwa DSN Nomor 62 DSN-MUI/XII/2007 Tentang Jualah
Authors: Ali Mahrus , Mahmudah Mahmudah
Published: March 2022

Perkembangan dari Game Online di Indonesia saat ini sedang berkembang cukup pesat. Hal tersebut tersalurkan melalui berbagai jenis karir atau profesi, seperti Game Devoloper, Game Publisher, Profesional Player, Streamer, bahkan Jasa Joki dari sebuah game itu sendiri, dalam penelitian ini, yang menjadi fokus penulis adalah analisa mengenai profesi jasa joki game online tadi melalui akad ju’alah khususnya dalam game Mobile Legend berdasarkan fatwa DSN No.62 Mui/XII/2007 Tentang Ju’alah. Fokus masalah yang diteliti dalam Skripsi ini adalah: 1) Bagaimana fenomena praktik transaksi jasa joki rank mobile legend melalui Sosial Media?, 2) Bagaimana analisis akad Ju’alah dalam transaksi jasa joki rank mobile legend berdasarkan fatwa DSN No.62 DSN-MUI/XII/2017 tentang ju’alah. Adapun dari tujuan penelitian ini adalah: 1) Mendeskripsikan praktik transaksi jasa joki Rank Mobile Legend melalui sosial media, 2) Menganalisis akad Ju’alah dalam transaksi jasa joki rank Mobile Legend perspektif fatwa DSN No.62 DSN-MUI/XII/2017 tentang Ju’alah. Jenis penelitian yang digunakan penulis adalah jenis penelitian kualitatif, yaitu mengacu pada data yang bersifat normatif dan sangat erat kaitanya dengan data-data yang bersifat kepustakaan dengan bertujuan untuk membuat analisa terhadap objek yang diteliti. Pada penelitian ini akan menganalisa Fatwa DSN No.62/DSN-MUI/XII/2007 Tentang Ju’alah. Akhir dari penelitian ini adalah bawah praktik transaksi jasa joki rank mobile legend merupakan komitmen dari seorang gamer untuk memberikan imbalan pada seseorang (pejoki) yang memainkan akun gamenya ketika mencapai rank/level yang diinginkan.
Pelaksanaan Izin Pertambangan Batu Kapur di Gunung Sadeng Jember Perspektif Hukum Lingkungan
Authors: Arini Dewi Puspita
Published: March 2022

Manusia telah menempatkan diri pada posisi sebagai khalifah Allah di bumi. Lingkungan yang sehat memberikan peluang bagi kelangsungan hidup ekosistem secara menyeluruh, sebaliknya lingkungan yang tercemar tidak akan mampu menunjang kelangsungan hidup secara menyeluruh. Oleh karena itu menciptakan lingkungan hidup yang berdampak positif bagi kemakmuran manusia itulah sebuah keharusan. Penyimpanan harta kekayaan atau dapat dikenal juga dengan istilah investasi, yang mana investasi merupakan penanaman modal yang dilakukan oleh investor, baik investor asing maupun domestik dalam berbagai bidang usaha yang terbuka untuk investasi, dengan tujuan untuk memperoleh keuntungan. Dalam hal ini investor melakukan berbagai cara untuk mendapat keuntungan dalam menyambung sebuah kehidupan. Investasi juga terdapat dalam sebuah lembaga keuangan, investasi juga bisa terdapat dalam bentuk pertambangan, seperti yang banyak terjadi di Indonesia berbagai macam jenis pertambangan terus tumbuh di negeri ini seperti pertambangan minyak bumi dan gas, batu bara, hingga pertambangan mineral. Namun dalam proses dan penerapan izin pertambangan tidak sedikit yang berujung menimbulkan konflik di kemudian hari. Salah satunya yakni penerapan izin pertambangan batu kapur di Gunung Sadeng Jember. Penelitian ini membahas mengenai penerapan izin pertambangan batu kapur di Gunung Sadeng Jember serta dampak dan resolusi permasalahnnya terhadap masyarakat Jember.