bluuebunny/crossref_metadata_2025 huggingface dataset:
Pharmacokinetics of Human Recombinant Anti-Botulinum Toxin Antibodies in Rats
Authors: Espinoza Yero , Wong David , Ahene Ago , Der Kenneth , Martinez Zachary , Pham John , Cobb Ronald R. , Farr-Jones Shauna , Marks James. D. , Tomic Milan T.
Published: June 2019

Botulinum neurotoxins (BoNT) are potential biothreat agents due to their high lethality, potency, and ease of distribution, thus the development of antitoxins is a high priority to the US government. This study examined pre-clinical pharmacokinetic studies in rats of four oligoclonal anti-BoNT mAb-based therapeutics (NTM-1631, NTM-1632, NTM-1633, NTM-1634) for five BoNT serotypes (A, B, E, C, and D). NTM-1631, NTM-1632, and NTM-1633 each consist of three IgG1 mAbs, each with a distinct human or humanized variable region which bind to distinct epitopes on BoNT serotype A, B, or E respectively. NTM-1634 consists of four human immunoglobulin G1 (IgG1) mAbs binding BoNT C/D mosaic toxins. The mechanism of these antitoxins requires that three antibodies simultaneously bind toxin to achieve rapid clearance. Rats (total 378) displayed no adverse clinical signs attributed to antibody treatment from any of the antitoxins. Pharmacokinetic evaluation demonstrated that the individual mAbs are slowly eliminated, exhibiting dose-dependent exposure and long elimination half-lives ranging from 6.5 days to 10 days. There were no consistent differences observed between males and females or among the individual antibodies in each formulation in half-life. Anti-drug antibodies (ADA) were observed, as expected for human antibodies administered to rats. The results presented were used to support the clinical investigation of antibody-based botulism antitoxins.
Recombinant Antibodies against Mycolactone
Authors: Naranjo Leslie , Ferrara Fortunato , Blanchard Nicolas , Demangel Caroline , D’Angelo Sara , Erasmus M. Frank , Teixeira Andre A. , Bradbury Andrew R.M.
Published: June 2019

In the past, it has proved challenging to generate antibodies against mycolactone, the primary lipidic toxin A of Mycobacterium ulcerans causing Buruli ulcer, due to its immunosuppressive properties. Here we show that in vitro display, comprising both phage and yeast display, can be used to select antibodies recognizing mycolactone from a large human naïve phage antibody library. Ten different antibodies were isolated, and hundreds more identified by next generation sequencing. These results indicate the value of in vitro display methods to generate antibodies against difficult antigenic targets such as toxins, which cannot be used for immunization unless inactivated by structural modification. The possibility to easily generate anti-mycolactone antibodies is an exciting prospect for the development of rapid and simple diagnostic/detection methods.
Toxin B Variants from Clostridium difficile Strains VPI 10463 and NAP1/027 Share Similar Substrate Profile and Cellular Intoxication Kinetics but Use Different Host Cell Entry Factors
Authors: López-Ureña Diana , Orozco-Aguilar Josué , Chaves-Madrigal Yendry , Ramírez-Mata Andrea , Villalobos-Jimenez Amanda , Ost Stefan , Quesada-Gómez Carlos , Rodríguez César , Papatheodorou Panagiotis , Chaves-Olarte Esteban
Published: June 2019

Clostridium difficile induces antibiotic-associated diarrhea due to the release of toxin A (TcdA) and toxin B (TcdB), the latter being its main virulence factor. The epidemic strain NAP1/027 has an increased virulence attributed to different factors. We compared cellular intoxication by TcdBNAP1 with that by the reference strain VPI 10463 (TcdBVPI). In a mouse ligated intestinal loop model, TcdBNAP1 induced higher neutrophil recruitment, cytokine release, and epithelial damage than TcdBVPI. Both toxins modified the same panel of small GTPases and exhibited similar in vitro autoprocessing kinetics. On the basis of sequence variations in the frizzled-binding domain (FBD), we reasoned that TcdBVPI and TcdBNAP1 might have different receptor specificities. To test this possibility, we used a TcdB from a NAP1 variant strain (TcdBNAP1v) unable to glucosylate RhoA but with the same receptor-binding domains as TcdBNAP1. Cells were preincubated with TcdBNAP1v to block cellular receptors, prior to intoxication with either TcdBVPI or TcdBNAP1. Preincubation with TcdBNAP1v blocked RhoA glucosylation by TcdBNAP1 but not by TcdBVPI, indicating that the toxins use different host factors for cell entry. This crucial difference might explain the increased biological activity of TcdBNAP1 in the intestine, representing a contributing factor for the increased virulence of the NAP1/027 strain.
Porcine Interferon Complex and Co-Evolution with Increasing Viral Pressure after Domestication
Authors: Jennings Jordan , Sang Yongming
Published: June 2019

Consisting of nearly 60 functional genes, porcine interferon (IFN)-complex represents an evolutionary surge of IFN evolution in domestic ungulate species. To compare with humans and mice, each of these species contains about 20 IFN functional genes, which are better characterized using the conventional IFN-α/β subtypes as examples. Porcine IFN-complex thus represents an optimal model for studying IFN evolution that resulted from increasing viral pressure during domestication and industrialization. We hypothesize and justify that porcine IFN-complex may extend its functionality in antiviral and immunomodulatory activity due to its superior molecular diversity. Furthermore, these unconventional IFNs could even confer some functional and signaling novelty beyond that of the well-studied IFN-α/β subtypes. Investigations into porcine IFN-complex will further our understanding of IFN biology and promote IFN-based therapeutic designs to confront swine viral diseases.
How Does Spatial Attention Influence the Probability and Fidelity of Colour Perception?
Authors: Hurst Austin J. , Lawrence Michael A. , Klein Raymond M.
Published: June 2019

Existing research has found that spatial attention alters how various stimulus properties are perceived (e.g., luminance, saturation), but few have explored whether it improves the accuracy of perception. To address this question, we performed two experiments using modified Posner cueing tasks, wherein participants made speeded detection responses to peripheral colour targets and then indicated their perceived colours on a colour wheel. In E1, cues were central and endogenous (i.e., prompted voluntary attention) and the interval between cues and targets (stimulus onset asynchrony, or SOA) was always 800 ms. In E2, cues were peripheral and exogenous (i.e., captured attention involuntarily) and the SOA varied between short (100 ms) and long (800 ms). A Bayesian mixed-model analysis was used to isolate the effects of attention on the probability and the fidelity of colour encoding. Both endogenous and short-SOA exogenous spatial cueing improved the probability of encoding the colour of targets. Improved fidelity of encoding was observed in the endogenous but not in the exogenous cueing paradigm. With exogenous cues, inhibition of return (IOR) was observed in both RT and probability at the long SOA. Overall, our findings reinforce the utility of continuous response variables in the research of attention.
Simulated Flow Velocity Structure in Meandering Channels: Stratification and Inertia Effects Caused by Suspended Sediment
Authors: Yang Fei , Shao Xuejun , Fu Xudong , Kazemi Ehsan
Published: June 2019

In this study, the coupled effects of sediment inertia and stratification on the pattern of secondary currents in bend-flows are evaluated using a 3D numerical model. The sediment inertia effect, as well as the stratification effect induced by the non-uniform distribution of suspended sediment, is accounted for by adopting the hydrodynamic equations without the Boussinesq approximation. The 3D model is validated by existing laboratory experimental results. Simulation results of a simplified meandering channel indicate that sediment stratification effect enhances the intensity of secondary flow via reducing eddy viscosity, while sediment inertia effect suppresses it. The integrated effects result in an increase and a reduction in the secondary flow, respectively, at lower and higher concentrations (near-bed volumetric concentrations of 0.015 and 0.1 are, respectively, considered in this study). This suggests that the dominance of the suspended sediment effect depends on the sediment concentration profile. With the increase of concentration under a specific sediment size, the secondary flow rises to reach a maximum, and then decreases. Moreover, as the sediment concentration increases, an exponentially decaying rate has been found for the secondary flow. It is concluded that in the numerical simulation of flow in meandering channels, when concentration is high, the variable-density hydrodynamic equations without the Boussinesq approximation should be considered.
Water Quality Changes during the Initial Operating Phase of Riverbank Filtration Sites in Upper Egypt
Authors: Wahaab Rifaat Abdel , Salah Ahmed , Grischek Thomas
Published: June 2019

To meet the increasing water demand and to provide safe drinking water in Egypt, the Holding Company for Water and Wastewater (HCWW) and its affiliated companies have started a program to develop riverbank filtration (RBF) sites in all Egyptian governorates. The paper gives an overview of water quality changes as a result of RBF, during the initial phase of operation at three sites in Upper Egypt, between 2015 and 2018. Significant changes were observed for chloride, sulfate, iron, manganese, ammonium, and in the bacterial counts. After the initiation of pumping from the RBF wells, it took 2 to 8 months until stable water quality was observed for the hydrochemical parameters and 2 to 14 months for the microbiological parameters. The results showed that RBF wells should be operated continuously, to maintain the advantage of lower Fe and Mn concentrations achieved by the wash-out effect in the aquifer zone, between the river bank and the RBF wells.
Temporal and Vertical Relations between Various Environmental Factors in the Largest Lake of Łęczna-Włodawa Lake District (Eastern Poland)
Authors: Ferencz Beata , Toporowska Magdalena , Dawidek Jarosław
Published: June 2019

Due to global warming and increasing water eutrophication, understanding in-lake relationships is paramount to prevent excessive pollution and further negative changes in lakes. The physico-chemical and biological parameters, as well as nutrient variabilities, both temporal and vertical (in the water column), were studied in the largest Łęczna-Włodawa lake. The study was conducted during two consecutive water years, from November 2015 to September 2017. The non-parametric Kruskal–Wallis ANOVA, test H was used to detect variability between years, and among seasons and lake depths in water temperature, electrical conductivity, pH, ORP, concentration of dissolved oxygen as well as concentration of NO3−, PO43−, TP and chlorophyll a. One-way analysis of variance (ANOVA) was used to detect any differences in Secchi depth (SD) and concentration of NH4+, NO2−, and TN. Ordination techniques: Detrended correspondence analysis (DCA), and Principal Components Analysis (PCA) were used to describe the relationships among 13 environmental variables and distribution of samples. Results showed significant differences (P < 0.05) between two years of the study for most variables except of water temperature, visibility, concentration of PO43−, TN and TP, which corresponded with highly different weather conditions in both years. All of the tested variables, except for nutrients, differed significantly among seasons. Most parameters showed fluctuation in depth, especially in summer and in winter, despite the fact that no hypolimnion or long-lasting thermocline was observed in the study period. However, variability of Chl-a was statistically significant only. The results emphasized complex and multi-directional relations between tested variables, dependent on both external (catchment) and internal (in-lake) processes.
Coastal and Marine Quality and Tourists’ Stated Intention to Return to Barbados
Authors: Schuhmann Peter , Skeete Ryan , Waite Richard , Bangwayo-Skeete Prosper , Casey James , Oxenford Hazel A. , Gill David A.
Published: June 2019

Seawater quality is critical for island and coastal communities dependent on coastal tourism. Improper management of coastal development and inland watersheds can decrease seawater quality and adversely impact marine life, human health, and economic growth. Agricultural runoff and improper sewage management compromise nearshore water quality in many coastal regions and can impact visitation decisions of tourists who are drawn to these destinations. The purpose of this paper is to understand how tourists’ decisions to revisit Barbados might be affected by changes in coastal and marine quality. We use data collected from tourists to examine how tourists’ stated willingness to return is affected by scenarios involving changes in seawater quality, beach width and coral reef health. Results reveal that return decisions are sensitive to changes in all aspects of coastal and marine quality. A reduction in seawater quality discourages tourists’ intention to return more than other environmental factors. These results are of paramount interest to destination managers, marketers and policymakers who rely on repeat visitation data to develop marketing strategies and infer future direction. This research highlights the importance of prioritizing seawater quality management to protect the coastal tourism product, especially in small island developing states (SIDS) with a high reliance on tourism income.
Research on the Anti-Disturbance Control Method of Brake-by-Wire Unit for Electric Vehicles
Authors: Gong Xiaoxiang , Qian Lixia , Ge Weiguo , Wang Lifeng
Published: June 2019

In order to improve the braking performance of electric vehicles, a novel brake-by-wire actuator based on an electro-magnetic linear motor was designed and manufactured. For the purpose of braking force regulation accuracy and high robust performance, the state observer and the anti-disturbance controller were designed in this paper after describing the actuator structure, braking principle, and mathematical model. The simulation and experimental results showed that the brake actuator responded rapidly, since its response time was only 15 ms. Compared to traditional PID (Proportion Integration Differentiation) methods, the controller proposed in this paper is able to regulate the braking force more precisely and has better anti-disturbance performance, thus the braking process can be accurately controlled according to the driver’s demand. The vehicle simulation results showed that the braking distance and braking time were shortened by 12.19% and 15.54%, respectively compared with those of the conventional anti-lock brake system (ABS) in the same braking conditions.
Implementasi Julian Day dalam Penentuan Waktu Shalat
Authors: Sutono Sutono
Published: June 2019

Tujuan dari perancangan Jam Shalat untuk mengatasi permasalahan waktu shalat setiap harinya, mulai dari Shubuh hingga Isya’. Dengan menggunakan algoritma perhitungan rumus penjadualan waktu shalat berdasarkan zona waktu, bujur, lintang, ketinggian, tanggal, bulan dan tahun, kita tidak perlu membuat database dan memasukkannya dalam memori Arduino sehingga memudahkan dalam penggunaan perhitungan waktu shalat tanpa perlu update data setiap tahunnya.
A Cell of Their Own: The Incarceration of Women in Late Medieval Italy
Authors: Geltner Guy
Published: June 2019

This article examines the earliest evidence from Florence's municipal prison (Le Stinche) in the fourteenth century concerning female inmates, who were locked in their own ward. Alongside sketching a social profile of this rather diverse group, it stresses that their undifferentiated treatment was both demeaning and yet ostensibly inconsequential.
SKILL MISMATCH DAN UPAYA MENGATASINYA (Studi pada 3 hotel di Semarang)
Authors: Dewi Yustina Erti Pravitasmara
Published: June 2019

This study aims to explain how to overcome the employee skill mismatch that works with the company. The research was conducted at the hotel because of the high of its business competition and the gap between the number of hospitality education institutions and the number of hotels in operation that had consequences for the occurrence of skill mismatch. The findings of a previous study of skill mismatch concluded that there was a disruption in competitiveness and productivity in companies using employees with skills and education gaps. Using a multi-case study technique, data collection was carried out in five-star hotels, three-star hotels and one-month period June-August 2018 in Semarang. The results of the study show that the effort to overcome the mismatch skill in the company is to conduct employee learning. There are differences in the learning process of employees in overcoming skill mismatch, where the higher the star classification in the hotel business the higher the involvement of the company. In other words, the smaller the classification of hotel stars, the individual efforts of employees to learn to overcome the mismatch skill is also greater. Based on these findings, this study uses the learning organization theory as a frame of mind and analysis.
Effect of liquid medium on shoots amplification, in vitro flowering and ex vitro rooting of Oldenlandia umbellata L. - A dye yielding medicinal herb
Authors: Jayabal Revathi , Mani Manokari , Rasangam Latha , Selvam Priyadharshini , Shekhawat Mahipal Singh
Published: June 2019

Oldenlandia umbellata L. gains importance due to its medicinal properties and the presence of anthraquinones based natural dyes in the roots. Present study describes the effect of Murashige and Skoog’s (MS) liquid medium (full strength) on in vitro regeneration, flower bud induction and ex vitro rooting in O. umbellata. Shoot segments with 2-3 nodes (each node with 2 axillary buds) served as explants for establishment of cultures. The liquid medium augmented with 2.0 mg L-1 6-benzylaminopurine (BAP) with additives (50 mg L-1 of ascorbic acid and 25 mg L-1 each of arginine, adenine sulphate and citric acid) was effective for shoot bud induction (6.4±0.19 shoots per explant within 2-3 weeks). The shoots were further multiplied (89.3±1.07 shoots, 2-3 weeks) when the shoot clusters obtained from the culture initiation directly transferred to the full-strength MS liquid medium incorporated with 1.0 mg L-1 BAP and 0.5 mg L-1 indole-3 acetic acid (IAA) with additives. Flower buds were induced (12.0±0.15 buds per shoot) when the shoots were cultured on 1.0 mg L-1 BAP and kinetin (Kin, 6-furfurylaminopurine) and 0.5 mg L-1 of IAA at 45 µmol m−2 s−1 SFPD (Spectral Flux Photon Density) light intensity for 14/10h (light/dark) photoperiod. The adventitious roots were induced on 1/4 strength MS medium supplemented with 1.5 mg L-1 indole-3 butyric acid (IBA). Ex vitro rooting was achieved (16.0±0.53 roots per shoot) by pulse treatment of the shoots with 300 mg L-1 IBA for 2 min. The in vitro produced plantlets were acclimatized in the greenhouse and finally translocated to the in vivo conditions with 93 % success rate. This is the foremost (use of liquid MS medium) and cost-effective method for large scale multiplication of O. umbellata.
Acute gamma irradiated Stevia rebaudiana Bertoni enhanced particular types of steviol glycosides
Authors: Chiew Miao Si , Lai Kok Song , Hussein Sobri , Abdullah Janna Ong
Published: June 2019

Stevia rebaudiana Bertoni from Asteraceae family is commercially valuable for its steviol glycosides (SGs) contents, which is 300 times sweeter than commercial sugar. The bottleneck in Malaysia is the lack of suitable stevia varieties that are able to thrive well under her climatic conditions and still produce high SGs. Mutation induction including gamma irradiation is effective in generating genetic variations and developing new plant varieties with desired traits. This study was aimed to determine the effects of acute gamma irradiation on phenotypic changes and enhancement of SGs contents of Stevia rebaudiana Bertoni variety AKH L1 (herein after will be designated as AKH L1). In vitro shoot tip explants of AKH L1 were subjected to a gamma doses regime of 10Gy to 50Gy, following which phenotypic changes of the irradiated explants and subsequent regenerated plantlets were observed. All irradiated explants exhibited different survival rates, with the lowest at 9.33±8.33% when subjected to 50Gy, while all the control (non-irradiated explants) survived. The LD50 was found to be at 23Gy. Subsequent irradiation of 900 shoot tip explants at 23Gy, produced 468 surviving shoot tips, which were all capable to develop and successfully sub-cultured until the fourth generation, M4. These M4 in vitro mutant plantlets exhibited significant increase in the numbers of leaf (16.07±5.19) and average leaf size (1.12±0.26cm x 0.54±0.15cm). HPLC analysis performed in parallel further revealed the mutant plants contained higher concentrations of stevioside (387.04ppm), rebaudioside A (670.18ppm) and rebaudioside D (106.26ppm) compared to the non-irradiated plantlets, which exhibited 96.87, 194.42 and 28.25ppm, respectively.
Analisis Tingkat Kompetensi Dosen Stmik Dharmasraya Dengan Menggunakan Metode Preference Ranking Organization Method For Enrichment Evaluation (Promethee)
Authors: Prima Wahyu , Putra Beni
Published: June 2019

Penelitian ini dilakukan untuk menganalisis tingkat kompetensi dosen STMIK Dharmasraya (Sekarang Menjadi Fakultas Ilmu Komputer Universitas Dharmasraya) yang selama ini dilakukan secara manual, yaitu dengan cara melakukan wawancara dengan mahasiswa, tenaga kependidikan, dosen, ketua program studi, dan ketua. Data dikumpulkan melalui studi lapangan/wawancara dan studi pustaka yang kemudian dirancang menjadi bentuk kuisioner. Selanjutnya data dianalisis dengan menggunakan metode Preference Ranking Organization Method for Enrichment Evaluation (Promethee). Melalui metode Promethee, tingkat kompetensi dosen Fakultas Ilmu Komputer Universitas Dharmas Indonesia dapat dilihat. Sistem pendukung keputusan dengan menggunakan metode ini diharapkan menghasilkan keputusan yang dapat dipertanggungjawabkan akuntabilitasnya. Berdasarkan hasil analisis melalui metode Promethee diperoleh hasil bahwa alternatif A4 memperoleh peringkat pertama dengan net flow sebesar 0,8750; A3 memperoleh peringkat kedua dengan net flow sebesar 0,1259; A2 memperoleh peringkat ketiga dengan net flow sebesar 0,0625; A5 memperoleh peringkat keempat dengan net flow sebesar -0,0625; A1 memperoleh peringkat kelima dengan net flow sebesar -1,0000.
Implementasi Sistem Penunjang Keputusan Dalam Upaya Efektifitas Penentuan Daerah Penghasil Penyu Untuk Kegiatan Monitoring Penangkaran Penyu Pada Kawasan Konservasi Perairan (Kkp) Kota Pariaman
Authors: Suherman Yanni , Astri Renita
Published: June 2019

Kawasan Konservasi Perairan (KKP) Kota Pariaman saat ini berkembang begitu pesat sejalan semangat otonomi daerah dan luas kawasan yang dialokasikan pemerintah kota Pariaman 11.525,89 Ha, yang mencakup pulau-pulau kecil kota Pariaman dengan ekosistemnya masih relatif alami dan terjaga. Dengan kondisi yang ada saat ini pengelolaan data di Pusat Penangkaran ini membutuhkan system yang lebih baik. Pada pusat konservasi ini begitu banyak telur penyu yang ditemukan, tetapi data telur penyu yang ditemukan ini hanya dicatat dalam sebuah buku dan untuk selanjutnya dikelola sederhana dengan memanfaatkan aplikasi Ms.Office Excel. Sewaktu-waktu jika dibutuhkan informasi tentang dimana daerah penghasil telur penyu terbanyak, berapa jumlah telur penyu yang telah ditemukan, jumlah telur penyu yang telah ditetaskan di peangkaran serta berapa jumlah tukik/anak penyu yang telah dilepas kembali ke biotanya, maka petugas KKP kesulitan memberikan informasi yang lengkap karena mereka harus melihat buku catatan dan menghitungnya kembali secara manual. Untuk itu perlu dirancang sebuah Sistem Pendukung Keputusan untuk mengolah seluruh data penangkaran penyu pada KKP Kota Priaman sehingga melalui system ini akan membantu dalam mengambil keputusan yang cepat, tepat dan up to date sehingga untuk menentukan daerah mana yang terbanyak menghasilkan telur penyu segera dapat diketahui untuk mendukung upaya pemerintah dalam mencegah kepunahan hewan penyu ini dari pihak-pihak yang tidak bertanggung jawab serta menjaga kelestarian penyu di kawasan kota Pariaman khususnya.
Aplikasi Sistem Penyidikan Berbasis Client Server Pada Ditreskrimsus Polda Riau
Authors: Sunarti Sunarti , Fitriandini Ira
Published: June 2019

Ditreskimsus Polda Riau merupakan unsur pelaksana tugas pokok yang berada dibawah Kapolda Riau yang menangani jenis tindak kejahatan khusus yang terbagi dalam 4 (empat) subbidang kejahatan. Aktivitas pelayanan masyarakat dalam hal penyidikan tindak pidana hingga pembuatan laporan dilakukan secara semi komputerisasi dan proses disposisi laporan yang masih dilakukan secara manual menjadi permasalah tersendiri sehingga perlu dirancang sebuah sistem berbasis client server yang dapat diakses oleh pimpinan dan personil secara langsung. Penelitian ini bertujuan untuk menghasilkan sistem penyidikan berbasis client server yang dapat membantu Kantor Ditreskrimsus Polda Riau dalam memberikan pelayanan yang lebih baik, cepat dan sistematis. Metodologi penelitian yang digunakan adalah System Development Life Cycle (SDLC). SDLC merupakan metodologi yang digunakan untuk mengembangkan, memelihara, dan mengganti sistem informasi. Melalui penelitian dan pengembangan sistem informasi pada Ditreskrimsus Polda Riau diperoleh hasil bahwa pemanfaatan penerapan sistem informasi penyidikan ini dapat memberikan solusi dalam proses penyidikan.
Sistem Informasi Pengolahan Data Tanaman Hias Dan Pohon Pelindung Di Taman Kota Pariaman
Authors: Amalina Amalina
Published: June 2019

Dinas Kebersihan dan Pertamanan Kota Pariaman memiliki permasalahan, yaitu penentuan jenis tanaman dan pohon pelindung secara manual masih memungkinkan terjadinya kesalahan dalam penentuan pemilihan tanaman yang menyebabkan tanaman mati karena tidak sesuai atau tidak cocok dengan kriteria tempat hidupnya. Laporan data belum terstruktur sehingga kurang efektif dan efisien. Untuk itu dibangun sebuah Sistem Informasi pengolahan data tanaman hias dan pohon pelindung di taman Kota Pariaman yang akan memudahkan pimpinan dalam menentukan jenis tanaman dan pohon pelindung. Skripsi ini menggunakan metode System Development Life Cycle (SDLC) yang terdiri dari empat langkah utama, yaitu perencanaan, analisis, perancangan, dan implementasi, serta menggunakan teori-teori yang telah didapat selama perkuliahan dan teori dari buku-buku penunjang
Sistem Informasi Administrasi Data Kemahasiswaan Berbasis Web Pada Universitas Lancang Kuning
Authors: Handayani Susi
Published: June 2019

Dari penelitian yang telah dilakukan pada Universitas Lancang Kuning Pekanbaru, khususnya pada Sistem Informasi Administrasi Akademik dikemukakan beberapa hal pokok yang perlu dibahas dan jadi perhatian utama pihak pengolahan data. Hal yang terpenting bahwa pada dasarnya pengolahan data sudah menggunakan sistim basis data secara pinsip, hanya saja belum dioperasikan secara totalitas dalam kinerja elektronis untuk menghasilkan layanan terhadap informasi. Melalui observasi langsung ke lapangan ditemui kelemahan-kelemahan sistem yang ada. Walaupun tidak secara keseluruhan dan lebih mengarah pada masalah yang spesifik, namun diharapkan dapat memberikan kontribusi yang berarti kepada pengguna sistem. Dengan memanfaatkan literatur-literatur ilmu informatika komputer, dan situs-situs yang relevan dengan permasalahan. Diakhiri dengan penelitian laboratorium dengan menerapkan siklus hidup pengembangan perangkat lunak dibuatlah sebuah aplikasi yang diharapkan dapat memecahkan permasalahan yang ada. Dengan menggunakan sistem informasi yang telah teruji kehandalannya , dibantu dengan sistem pelaporan dengan platform yang sudah sangat dikenal dan dengan menggunakan bahasa pemrograman yang berbasis Grafic User Interface serta pemanfaatan penggunaaan jaringan komputer berbasis web yang diharapkan dapat meningkatkan efisiensi kerja bagian yang terkait, hingga pada akhirnya tujuan yang diharapkan dapat tercapai.Dan terutama sekali sasaran akhirnya adalah sebagai sumbangan nyata terhadap ilmu pengetahuan hingga pada gilirannya dapat disajikan informasi yang benar-benar berkualitas.
Malzeme Modellerinin Sac Metal Sonlu Elemanlar Analizi Tahmin Performansına Etkisinin Değerlendirilmesi
Authors: KÖLEOĞLU GÜRSOY Özlem , ESENER Emre
Published: June 2019

Sac metaller ağırlık/dayanım oranlarından ötürü başta
otomotiv olmak üzere pek çok sektörde tercih edilmektedirler. İnce malzemelerle
çalışıldığından ve karmaşık ürün formları hedeflendiğinden sac metal şekillendirme
prosesleri genelde karmaşık prosesler olarak karşımıza çıkmaktadırlar.
Çoğunlukla seri üretim ürünü olarak tercih edilmelerinden dolayı sac metal
kalıp takımları oldukça pahalıdırlar. Bu nedenle kalıp takımlarının tasarım
aşamasında telafi edilme zorunluluğu ortaya çıkmıştır. Günümüzde bu amaçla en
sık kullanılan yöntem sonlu elemanlar analizidir. Sonlu elemanlar analizlerinin
ise tahmin hassasiyetlerinin yüksek olması gerekmektedir. Hassasiyete etki eden
en baskın parametre ise malzemelerin plastik davranışının tanımlandığı malzeme
modelleridir. Bu çalışmada sonlu elemanlar malzeme modellerinin tahmin
performansına etkisi incelenmiş olup bu amaçla derin çekme, kare kutu çekme ve
V-kalıpta eğme prosesleri 4 farklı malzeme (DP600, DP980, DC05, AA5754) için
incelenmiştir. Çalışmada izotropik malzeme-izotropik pekleşme kabulü yapan
(Power Law), anizotropik malzeme-izotropik pekleşme kabullü (Hill-48,
Barlat-89) ve anizotropik malzeme - kinematik pekleşme kabullü (Yoshida -
Uemori) dört farklı malzeme modeli kullanılmıştır. Gerçekleştirilen simülasyon
sonrasında sonuçlar deneysel verilerle kıyaslanarak sonlu elemanlar tahmin
performansları ortaya konulmuştur. En hassas tahminlerin tüm modellerde
kinematik pekleşme kabullü malzeme modeli ile elde edildiği tespit edilmiştir.
IMPLEMENTASI GYROSCOPE-ARDUINO PADA KENDALI KESEIMBANGAN
Authors: Nurraharjo Eddy , Budiarso Zuly
Published: June 2019

Gyroscope merupakan salah satu fitur yang dimiliki oleh modul GY-521, disamping kemampuan accelerometernya. Fokus pengamatan pada penelitian ini adalah upaya untuk membuat konsep antarmuka terhadap gyroscope-accelerometer dengan mengintegrasikannya bersamaan dengan modul Arduino UNO R3.

Arduino menjadi inti dalam pemrosesan sinyal yang dihasilkan dari modul GY-521, dan diolah dengan formulasi sederhana menggunakan konsep segitiga siku-siku, unutk kemudian dihailkan data keluaran dengan simulasi menggunakan motor servo, sebagai indikasi pitch dan roll.

Hasil penelitian ini adalah model komunikasi interaksi hasil perancangan antarmuka sistem yang diamati, dan mampu memberikan hasil pendekatan terhadap perubahan sudut dan respon motor servo terkendali dengan formulasi segitiga siku-siku dan batasan sudut 90 derajat sudut gerakan. Simulasi diberikan pada range sudut sebesar -90 hingga +90 derajat. Library yang terlibat dalah Wire.h, SPI.h dan Servo.h yang diperoleh dari internet.
OPTIMALISASI PENCARIAN LINTASAN TRAVELING SALESMAN PROBLEM MENGGUNAKAN ALGORITMA BACKTRACKING
Authors: Murti Hari , Supriyanto Edy , Sugiyamta Sugiyamta
Published: June 2019

Tujuan pemecahan masalah penjual atau wira niaga keliling (traveling salesman problem, TSP) adalah menentukan lintasan atau rute dengan total jarak atau biaya yang paling minimum. Penelitian ini berkenaan dengan proses optimalisasi pencarian alternatif lintasan atau rute pada masalah TSP. Penjual mencari rute atau lintasan untuk mengunjungi semua kota yang ada sebanyak satu kali kunjungan. Proses optimalisasi pencarian alternatif menggunakan algoritma backtracking.

Terdapat lima buah kasus TSP yang akan digunakan yaitu TSP1 memiliki 4 buah kota dengan 6 lintasan (jalur), TSP2 memiliki 5 buah kota dengan 10 lintasan, TSP3 memiliki 6 buah kota dengan 15 lintasan, TSP4 memiliki 7 buah kota dengan 21 lintasan, dan TSP5 memiliki 8 buah kota dengan 28 lintasan. Dari hasil pengujian diperoleh algoritma runut-balik (backtracking) dapat digunakan untuk menghasilkan jumlah alternatif lintasan yang lebih sedikit jika dibandingkan dengan total kombinasi alternatif lintasan. Semakin besar jumlah node (kota) dan jumlah lintasan (jalur) maka prosentase pengurangan variasi (alternatif) akan lintasan semakin besar.
PERANCANGAN SISTEM INFORMASI PEMBUATAN PASS BANDARA BERBASIS WEB PADA PT. ANGKASA PURA I SEMARANG
Authors: Wicaksono Wibowo , Luthfiarta Ardytha , Shobri Hasan
Published: June 2019

PT. Angkasa Pura I (Persero) Cabang Bandara Internasional Ahmad Yani Semarang ini adalah salah satu Badan Usaha Milik Negara yang bergerak di bidang kebandarudaraan. Pada PT. Angkasa Pura I (Persero) Cabang Bandara Internasional Ahmad Yani Semarang terdapat sebuah bidang bernama ITC (Information Technology and Communication) bagian yang menangani yang salah satu tugasnya adalah Menyiapkan dan melakukan kegiatan pengoperasian, pemeliharaan dan pelaporan fasilitas IT. PT. Angkasa Pura I (Persero) Cabang Bandara Internasional Ahmad Yani Semarang yang menjadi tempat penulis dalam melakukan penelitian untuk proses pembuatan pass bandara baru yang masih dilakukan secara manual. Maka untuk mempermudah dan meningkatkan efisiensi pekerjaan penulis membangun sebuah sistem informasi berbasis web yang mengatur proses pembuatan pass bandara baru.
Implementasi Metode UMMI untuk Meningkatkan Kemampuan Bacaan Al-Quran Siswa di SMPIT Anni’mah Margahayu
Authors: Fajriani Delfi
Published: June 2019

Today many schools are based on Islam that is quality oriented. One guarantee of the quality their graduates in guardian students is the ability to read al-Quran well in every child. However, the current phenomenon is a lack of improvement in learning it especially in reading  al-Quran in several schools. The UMMI method helps institutions and teachers improve the ability to process Qur'anic learning that is effective, easy, fun and touching. This study uses a quasi-experimental method, using the quasi experimental design; the instruments used are observation, interviews, direct tests and documentation. The research was carried out in MIPA VIIIT class VII of Anni'mah Margahayu as the experimental class and class VII A of Muhammadiyah Margahayu as a control class with UMMI teacher subjects and 25 students in each class.  Based on the results of the analysis of the Paired Test T-test samples in the experimental class that were treated with learning using the UMMI method, it is known that the sig value. (2-tailed) of 0,000 <0,05. Because the sig value. (2-tailed) 0,000 smaller than 0.05, it can be concluded that the use of the UMMI method in the experimental class can improve students' Koran reading abilities.
Model Komunikasi di Lembaga Pendidikan Islam
Authors: Amrullah Abdul Malik Karim , Fanani Zainuddin
Published: June 2019

Communication is a need that is very fundamental for someone in living in a community. Communication and society are two twin words that cannot be separated from each other. Islamic education has meaning as a process of developing and saving human nature. Islamic education does not only develop the body, spirituality, soul and even reason, but how can the four potentials develop and survive. Islamic education institutions are a place, or the place where the process of Islamic education takes place. Islamic education institutions include families, mosques, Islamic boarding schools and madrasas. Institutions that are attached to the soul of Muslims are of two forms, the first form is an institution that cannot be changed and the second form is an institution that can be changed. Islamic education institutions have challenges that must be faced, namely in the fields of politics, culture, science and technology, economics, society and social change, and value systems, and all of them must be neutralized in order to go hand in hand and support each other. Islamic communication models, including human relations with God, human relations with humans, and human relations with themselves. While the communication model in Islamic educational institutions, combines forms of Islamic communication, Islamic communication sources, and basic concepts of Islamic communication.
SUPLEMENTASI VITAMIN A BAGI IBU POST PARTUM DAN BAYI
Authors: Maryani Deni
Published: June 2019

Retinol supplement (Vitamin A) functions to reduce mortality and morbidity, vitamin A plays a role in the immune system, maintains against infections such as measles, diarrhea, and ARI. Other consequences that have a very serious impact on vitamin A deficiency (KVA) are night blindness, corneal damage, and blindness. Mother's milk is the main source of nutrition for babies because babies only consume breast milk until they are 6 months old, the perinatal period and neonatal risk of running out of nutrient reserves, especially for mothers who suffer from micronutrient deficiency. Provision of vitamin A supplements to postpartum mothers serves to maintain Retinol levels in red blood cells and breast milk because breast milk is the main food containing vitamin A supplements obtained by babies to prevent Xerophthalmia. This study was a literature review using computerized data searches namely BMC Pediatrics, the Cochrane Collaboration, Journal de Pediatria, ISRN Public Health, European Clinical and Nutrition Journal, and Food Journal. In response to vitamin A deficiency in Indonesia, the Indonesian Ministry of Health makes an effective and beneficial strategy in improving or preventing high doses of vitamin A in infants, toddlers, and postpartum mothers. In this literature study, the authors limit only discussing the provision of vitamin A in postpartum mothers.

 

Keywords: Post Partum, Vitamin A

ABSTRAK

 

Suplemen retinol (Vitamin A) berfungsi untuk menurunkan angka kematian dan angka kesakitan, vitamin A berperan terhadap sistim kekebalan tubuh, mempertahankan terhadap infeksi seperti campak, diare, dan ISPA. Akibat lain yang berdampak sangat serius dari kekurangan vitamin A (KVA) adalah buta senja, kerusakan kornea dan kebutaan. Air Susu Ibu adalah sumber gizi utama bagi bayi        karena bayi hanya mengkonsumsi ASI saja sampai berumur 6 bulan, periode perinatal dan neonatal berisiko untuk kehabisan cadangan gizi, terutama untuk ibu yang menderita defisiensi mikronutrient. Pemberian suplemen vitamin A pada ibu nifas berfungsi menjaga kadar Retinol dalam sel darah merah dan ASI, karena air susu ibu  adalah makanan utama yang mengandung suplemen vitamin A didapat bayi untuk mencegah Xeroftalmia. Studi ini merupakan tinjauan literatur Menggunakan pencarian data terkomputerisasi yaitu BMC Pediatrics, the Cochrane coboration, Journal de pediatria, ISRN public Health, jurnal klinik dan nutrisi Eropa, dan jurnal pangan. Penanggulangan kekurangan vitamin A di Indonesia, Departemen Kesehatan RI membuat strategi yang efektif dan bermanfaat dalam memperbaiki atau mencegah kekurangan vitamin A dosis tinggi pada bayi, balita, dan ibu nifas. Pada studi literatur ini penulis membatasi hanya membahas pemberian vitamin A pada ibu nifas.

Kata Kunci: Post Partum, Vitamin A
FAKTOR-FAKTOR RESIKO PENYEBAB TERJADINYA STUNTING PADA BALITA USIA 23-59 BULAN
Authors: Ariati Linda Ika Puspita
Published: June 2019

Stunting is a chronic malnutrition problem that occurs in toddlers which causes short toddlers and linear growth retardation (RPL) which can subsequently affect health outwardly but includes mental and emotional health, even intelligence or intellect. The purpose of this study was to determine and analyze the relationship between risk factors that cause stunting in infants aged 23-59 months in Panduman village. The research design used cross-sectional with 111 samples of toddlers obtained by simple random sampling. Data measurement through TB measurement, questionnaire interview, and food recall and analysis using Chi-square. The results showed the prevalence of stunting was 32.5% and normal toddlers were 67.5%. Statistical analysis showed a significant relationship between the factors of death (maternal age at pregnancy, maternal nutritional status during pregnancy), postnatal factors (Exclusive breastfeeding, immunization history, infectious diseases), family characteristics (maternal education, father's work, and socioeconomic status) with the incidence of stunting.  

 Keywords: Stunting, Causative factor, Toddlers Aged 23-59 Months.

ABSTRAK

 Stunting merupakan masalah kekurangan gizi kronis yang terjadi pada balita yang menyebabkan balita pendek dan terjadi retardasi pertumbuhan linear (RPL) yang selanjutnya dapat berdampak pada kesehatan secara lahiriah, namun meliputi kesehatan jiwa dan emosi, bahkan kecerdasan atau intelektualnya. Tujuan penelitian ini untuk mengetahui dan menganalisis hubungan faktor-faktor resiko penyebab terjadinya stunting pada balita usia 23-59 bulan di desa Panduman. Desain penelitian menggunakan cross sectional dengan jumlah sampel 111 balita yang didapat dengancara simple random sampling. Pengukuran data melalui pengukuran TB, wawancara Kuesioner, dan Foodrecall dan Analisis menggunakan Chi square.  Hasil penelitian menunjukkan prevalensi stunting sebesar 32,5 % dan balita Normal 67,5%. Analisis uji statistik menunjukkan adanya hubungan bermakna antara faktor prenatal (usia ibu saat hamil, status gizi ibu saat hamil), faktor pascanatal (ASI Eksklusif, riwayat imunisasi, penyakit infeksi), Karakteristik keluarga (pendidikan ibu, pekerjaan ayah dan status sosial ekonomi) dengan kejadian stunting.

 Kata Kunci : Stunting, Faktor Penyebab, Balita Usia 23-59 Bulan.
STUDY ON FEEDING HABIT AND FEED SPECTRUM OF GOLDEN TANK GOBY Glossogobius aureus Akihito & Meguro, 1975
Authors: Nguyen Tuan Minh , Tran Dinh Dac
Published: June 2019

Glossogobius aureus Akihito & Meguro, 1975 is a fish with good flesh, which has brought about high economic value. The study on feeding habit and feed  spectrum of G. aureus was conducted from January to December 2013 at the coastal area of Ben Tre province. The results have showed that the mouth of thisfish is wide, tongue is bilobate, teeth on faws develop well. The gill rakers are sparse, short and hard. The esophagus and the intestine are short, the stomach and intestinal walls are thick. The Relative Length Gut index (RLG) of G. aureus was less than 1. The results also indicated that G. Aureus are fed mainly on small fish (46.3%) and crustaceans (40.5%). The result showed that G. aureus is the carnivorous species
EVALUTING FARMING EFFICIENCY TO HIGH QUALITY RICE IN AN GIANG
Authors: Truong Tan Van
Published: June 2019

The research is conducted in order to evaluate the efficiency in farming of high quality rice in An Giang province, associated with the strategic orientation of rice export market in Viet Nam. Data envelopment analysis (DEA) was used to estimate efficient farming with size variable return to scale and efficiency farming without size in variable returns to scale. On variable return to scale, the average of technical efficiency was 87,05%, the average of allocating efficiency was 78,37%, the average of cost efficiency was 67,99%. On invariable returns to scale, the average of technical efficiency was 80,91%, the average of allocating efficiency was 63,80%, the average of cost efficiency was 58,32%. Tobit model appeared dependent variable to efficient farming returns to scale and independent variable offered to define factors that affected farming efficiency. As a result, the research identified 04 influential factors to farming efficiency including profession, experiences, farming agreement, and quantity of seed.
ANALYZING VALUE CHAIN OF BEEF IN TRA VINH PROVINCE
Authors: Danh Ut , Nguyen Linh Thi Yen
Published: June 2019

Investigating agents in the beef value chain in Travinh province aims to assess the status production, processing and consumption of beef products by a value chain approach. The results show that process of product consumption from farmers to final consumers has a very close connection creating a distribution network in which agents play an important role to convert products to consumers. However, there are many intermediate stages for carrying the products to consumers. Businessmen dominate buying and selling prices which have affected to unfair competition in the market. Therefore, in order to solve this problem, it is necessary to design a stable inoutput market for beef products.
IMPROVING THE SENSORY PROPERTIES OF WOOD-APPLE EFFERVESCENT TABLET PROTOTYPES USING IPM
Authors: Le Tam Minh , Quoc Toan Tram , Nguyen Tham Thi Hong
Published: June 2019

This study aims to improve the sensory properties of wood-apple effervescent tablets. Six prototypes were rated by 105 consumers using Ideal Profile Method (IPM). In a practical manner, IPM consists of two consumer tasks: (1) rate each product or prototype on both perceived and ideal intensity for 6 sensory properties including: effervescent, yellow colour, wood-apple odour, sour taste, sweet taste, and salty taste; and (2) rate the corresponding prototype on overall liking. The results showed that P2 and P5 were preferred to other prototypes with 50% of consumers accepted. In addition to that, the results highlighted trends for prototype improvement with the proviso that P5 will approach the zone of maximum liking with 80% of consumers accepted in the case where the intensityof its sour taste can be decreased two times. We expect that the results of this study will benefit R&D staff in food and pharmaceutical companies who want to  diversify their local products.
IMPACT OF LENDING STRUCTURE ON CREDIT RISK IN VIETNAMESE COMMERCIAL BANKS
Authors: Le Diem Thi Thu , Diep Tung Thanh
Published: June 2019

This study examines whether lending structure concentration leads to lower credit risk by employing GMM estimators of panel data for the Vietnamese banking system at the bank level by economic sector from 2009 to 2016. The advance point of this research is the effect of different industrial sector variables on credit risk. An important finding is that the Vietnamese commercial bank lending portfolios have, on average, higher levels of diversity across different sectors. Overall, the research finds that an increase in the mining and quarrying, manufacturing, electricity, gas and water, construction and real estate lending will contribute to the bank’s exposures to credit risk, while the lending portfolio of banks in wholesale and retail trade and other sectors reduces credit risk. This study suggests recommendations in lending activity for maintaining efficiency and stability in Vietnamese commercial banking system.
SURVEY OF DISEASE MODEL AT TRA VINH UNIVERSITY GENERAL CLINIC
Authors: Nguyen Tao Nhat Thi , Huynh Linh Thi Xuan , Huynh Nhi Thi Thuy , Nguyen Van Kim Thi
Published: June 2019

The study is to identify disease model and relevant factors at the General Clinic of Tra Vinh University (GC-TVU). A crosssectional survey of 42.884 patients who underwent medical treatment at GC-TVU from August 2016 to August 2017. The results showed that non-infectious diseases accounted for 62,4%, two times higher than that of infectious diseases (30,9%) and more than 9 times as compared with the trauma group, accident, poisoning (6,8%). The high rate of mental illness included 21,1% mental disorders, 19.8% infections and parasites, and 15,8% circulatory disease. The most common diseases are high blood pressure 11,4%, muscle pain 6,4%, back pain 5,9%, diabetes mellitus 3,7% and gastric inflammation 3,2%. The disease structure is closely related to age, sex and areaof living. This result is the basis for investing infrastructure and faculties and training of human resources in order to meet people’s needs and to improve the quality of health care routes.