bluuebunny/crossref_metadata_2025 huggingface dataset:
THE IMPACT STRESS SYMPTOM AND MOTIVATION TO PERCEIVED PRODUCTIVITY WORK FROM HOME COMPARISON WORK FROM OFFICE IN INDONESIA
Authors: Sakina Ihda Salma
Published: August 2024

This research aims to determine the effect of stress symptom and motivation on perceived productivity work from home and work from office as a new company culture. This research approaches associative and quantitative with a sample of 114 respondents. The results shows on work from office if the stress symptom variable is high, perceived productivity is low. Furthermore, stress symptoms on work from the office are less than stress symptoms on work from home. Besides it, if the motivation variable increases, perceived productivity will also increase, while motivation on work from the office is higher than motivation on work from home. The results of the study show that the hypothesis can be accepted.
Book Review: â€œAspek Hukum Perlindungan Anak dan Sistem Pencatatan Kelahiran
Authors: Latif Inas Sofia
Published: August 2024

Buku ini ditulis oleh Dr. Haznah Aziz, S.H., M.H., dosen pengampu mata kuliah pada Program Pascasarjana Magister Ilmu Hukum, Universitas Islam Syekh-Yusuf, Tangerang. Selain mengajar beliau juga aktif dalam berbagai kegiatan penelitian serta penulisan, baik dalam bentuk artikel dan buku. Karya tulis yang beliau buat mayoritas membahas mengenai perlindungan hukum terhadap anak, sebagaimana dapat kita lihat dalam profil Google Scholarnya. Penulis aktif melakukan penulisan artikel pada beberapa jurnal terakreditasi nasional dan internasional. Buku Aspek Hukum Perlindungan Anak dan Sistem Pencatatan Kelahiran ini merupakan salah satu hasil pemikiran beliau dalam bidang Hukum Perlindungan Anak.
In vitro detection of marine invertebrate stem cells: utilizing molecular and cellular biology techniques and exploring markers
Authors: Mohajer Fatemeh , Khoradmehr Arezoo , Riazalhosseini Behnaz , Zendehboudi Tuba , Nabipour Iraj , Baghban Neda
Published: August 2024

Marine invertebrate stem cells (MISCs) represent a distinct category of pluripotent and totipotent cells with remarkable abilities for self-renewal and differentiation into multiple germ layers, akin to their vertebrate counterparts. These unique cells persist throughout an organism’s adult life and have been observed in various adult marine invertebrate phyla. MISCs play crucial roles in numerous biological processes, including developmental biology phenomena specific to marine invertebrates, such as senescence, delayed senescence, whole-body regeneration, and asexual reproduction. Furthermore, they serve as valuable models for studying stem cell biology. Despite their significance, information about MISCs remains scarce and scattered in the scientific literature. In this review, we have carefully collected and summarized valuable information about MISC detection by perusing the articles that study and detect MISCs in various marine invertebrate organisms. The review begins by defining MISCs and highlighting their unique features compared to vertebrates. It then discusses the common markers for MISC detection and in vitro techniques employed in invertebrate and vertebrates investigation. This comprehensive review provides researchers and scientists with a cohesive and succinct overview of MISC characteristics, detection methods, and associated biological phenomena in marine invertebrate organisms. We aim to offer a valuable resource to researchers and scientists interested in marine invertebrate stem cells, fostering a better understanding of their broader implications in biology. With ongoing advancements in scientific techniques and the continued exploration of marine invertebrate species, we anticipate that further discoveries will expand our knowledge of MISCs and their broader implications in biology.
Circulating miRNA-21 as early potential diagnostic biomarker for acute myocardial infarction: a meta-analysis
Authors: Wang Ke , Li Kai , Li Zhuoyuan , Yan Xizhang
Published: August 2024

Introduction

There exists a knowledge gap concerning the clinical significance of miRNA-21; therefore, in the present study, we aimed to estimate the diagnostic and prognostic accuracy and sensitivity of miRNA-21 in acute myocardial infarction (AMI) by performing an evidence-based meta-analysis of previous AMI-related clinical studies.

Methods

Chinese and English literature published before April 2024 were searched, and data were reviewed and extracted. After quality appraisal, the STATA 16.0 software was used for the effect size analysis of the various treatments described in the literature.

Results

A total of 14 valid documents were retrieved from 562 studies. The results of the systematic review revealed that for the patients with AMI vs. those without non-AMI, the aggregated odds ratio reached 5.37 (95% confidence interval 3.70–7.04). The general sensitivity and specificity for the circulating miRNA-21 levels in diagnosing AMI were 0.83 and 0.81, respectively.

Discussion

Thus, the meta-analysis of 14 AMI-related clinical trials highlighted that miRNA-21 may serve as a promising biomarker for diagnosing AMI.
Unraveling the interplay: early-stage atrial functional mitral regurgitation and left atrial electrical substrate in atrial fibrillation patients
Authors: Mohsen Yazan , Rottländer Dennis , Großmann Nora , Lewandowski Nicole , Horlitz Marc , Stöckigt Florian
Published: August 2024

Background

Atrial fibrillation (AF) triggers atrial remodeling, impacting atrial function and ablation efficacy. This remodeling leads to atrial cardiomyopathy and dilatation, linked to mitral regurgitation, forming atrial functional mitral regurgitation (aFMR). Our study explores the relationship between early-stage-aFMR and the atrial electrical architecture, focusing on left atrial bipolar voltage and low-voltage areas (LVAs) in AF patients.

Methods

We enrolled 282 patients undergoing redo-PVI after AF recurrence post-PVI. Echocardiography was performed prior to ablation, and only patients with no, mild, or mild-to-moderate aFMR were included. Ablation used radiofrequency and a 3D mapping system, with atrial voltage documented on each atrial wall. LVAs were calculated using high-density maps, and patients were followed for 15 months.

Results

Significant differences in left atrial voltage and LVA extent were observed based on aFMR severity. Patients with aFMR 1 + had significantly lower atrial voltage compared to no-aFMR, but no significant increase in LVAs. Patients with aFMR 2 + showed lower voltage amplitudes in all atrial regions and larger LVAs compared to no-aFMR patients. AF recurrence was significantly higher in the aFMR group (62.9% vs. 48.3%, p = 0.027) within 1 year. aFMR was associated with AF recurrence after adjusting for sex, age, and AF types (HR: 1.517, 95% CI: 1.057–2.184, p = 0.025).

Conclusion

aFMR in AF patients may indicate progressive atrial remodeling and left atrial cardiomyopathy, characterized by reduced atrial voltage and increased LVAs. aFMR is linked to PVI outcomes, suggesting its consideration in AF therapy decision-making.
Left ventricular outflow tract obstruction after transcatheter mitral valve replacement: a case report with a multifaceted approach
Authors: Caneiro-Queija Berenice , Guerreiro Claudio E. , Echarte-Morales Julio , Estévez-Loureiro Rodrigo , Barreiro-Pérez Manuel , González-Ferreiro Rocío , Estévez-Cid Francisco , Legarra Juan José , Baz Jose Antonio , Íñiguez-Romo Andrés
Published: August 2024

An 83-year-old woman was admitted to our center because of heart failure. Transthoracic echocardiography revealed severe mitral annular calcification resulting in a double mitral valve lesion. After discussion by the heart team, transcatheter mitral valve replacement with Tendyne (Abbott Structural, Santa Clara, CA, USA) was performed. Despite having a predicted neo-left ventricular outflow tract (LVOT) above the cut-off value, the patient developed clinically significant LVOT obstruction (LVOTO) refractory to medical treatment. This situation is often treated before the intervention, and dealing with LVOTO afterward can be challenging. After taking the patient's anatomy into consideration, we decided to perform alcohol septal ablation. Applying a combined strategy of medical treatment and intervention led to success. In this case report, we discuss this event and the strategies available for preventing and managing the condition.
Protein tyrosine phosphatase 1B in metabolic and cardiovascular diseases: from mechanisms to therapeutics
Authors: Sun Yan , Dinenno Frank A. , Tang Peiyang , Kontaridis Maria I.
Published: August 2024

Protein Tyrosine Phosphatase 1B (PTP1B) has emerged as a significant regulator of metabolic and cardiovascular disease. It is a non-transmembrane protein tyrosine phosphatase that negatively regulates multiple signaling pathways integral to the regulation of growth, survival, and differentiation of cells, including leptin and insulin signaling, which are critical for development of obesity, insulin resistance, type 2 diabetes, and cardiovascular disease. Given PTP1B's central role in glucose homeostasis, energy balance, and vascular function, targeted inhibition of PTP1B represents a promising strategy for treating these diseases. However, challenges, such as off-target effects, necessitate a focus on tissue-specific approaches, to maximize therapeutic benefits while minimizing adverse outcomes. In this review, we discuss molecular mechanisms by which PTP1B influences metabolic and cardiovascular functions, summarize the latest research on tissue-specific roles of PTP1B, and discuss the potential for PTP1B inhibitors as future therapeutic agents.
Successful percutaneous coronary intervention of left main coronary artery dissection following mechanical aortic valve replacement surgery: a case report and literature review
Authors: Vu Vu Hoang , Truong Hung Phi , Tran Hoa , Cao Khang Dang , Duong Bao Thien , Tran Thuy Thanh Thi , Truong Binh Quang
Published: August 2024

Background

Iatrogenic left main coronary artery (LMCA) dissection resulting from cardiac surgery is a rare complication. Its early detection is challenging and often poses a significant threat to the patient's life. However, evidence regarding the most effective management strategy for this condition remains limited at present.

Case presentation

We present a case of 65-year-old female patient who developed cardiogenic shock after mechanical aortic valve replacement surgery associated acute myocardial infraction. Despite concurrent coronary artery bypass graft (CABG) surgery, the patient's condition remained unimproved. Subsequent coronary angiography revealed extensive LMCA dissection involving the left circumflex (LCx) artery. Percutaneous coronary intervention (PCI) guided by intravascular ultrasound (IVUS) led to an immediate improvement in hemodynamic status. The patient was successfully discharged after 22 days of treatment.

Conclusions

Iatrogenic LMCA dissection is an uncommon complication following cardiac surgery. It can manifest in a variety of ways, including as incidental findings, cardiogenic shock or sudden cardiac arrest. The precise prevalence rates of causes linked to cardiac surgery remain largely unknown due to the scarcity of reported cases and the absence of research on this issue. Currently, a definitive management strategy for this condition has not been established. However, previous reported clinical cases provide insight that CABG could be considered if coronary artery dissection is detected during cardiac surgery. Upon postoperative identification, diagnostic coronary angiography and PCI may be feasible alternatives.
A study of 3D axis anisotropic response of MT
Authors: Liu Xiao , Sun Qi-Ji
Published: August 2024

Electrical anisotropy has a significant impact on the observation data of the magnetotelluric (MT) method; therefore, it is necessary to develop forward and inverse methods in electrical anisotropic media. Based on the axis anisotropic electric field control equations, forming a large linear equation through staggered finite difference approximation, adding boundary conditions, and using the quasi-minimum residual method to solve the equation, this study obtained MT forward modeling results in axis anisotropic media. The correctness of the algorithm was verified by comparing it with the 2D quasi-analytic solution. By designing several sets of axis anisotropic 3D models, the characteristics of the apparent resistivity tensor and tipper were analyzed. The results indicated that the ρxya, ρyya and Tzy are sensitive to changes in resistivity in the X direction of the anomalous body, whereas the ρyxa, ρxxa and Tzx are sensitive to changes in resistivity in the Y direction. The apparent resistivity tensor and tipper are insensitive to changes in resistivity in the Z direction of the anomalous body. For exploration of anisotropic media, the apparent resistivity tensor and tipper of MT can identify the changes in resistivity in two horizontal axes directions and the boundaries of the anomalous body, which has the advantages for exploration.
Task-irrelevant visual distractions and mindful self-regulated learning in a low-stakes computer-based assessment
Authors: Wolff Sarah M. , Wright Daniel B. , Hatcher Wilson J.
Published: August 2024

Introduction

There is a growing concern about the threat of distractions in online learning environments. It has been suggested that mindfulness may attenuate the effects of distraction. The extent to which this translates to academic performance is under investigation. We aimed to investigate the relationship between task-irrelevant visual distraction, time pressure, and mindful self-regulated learning in the context of a low-stake computer-based assessment.

Methods

The study sampled 712 registered users of Prolific.co who were prescreened, current undergraduate university students. After data quality screening, 609 were retained for analyses. A 2 × 2 between-subjects design was used. Participants were randomly assigned to the following groups: (1) a control condition, (2) a distract condition, (3) a time pressure condition, or (4) a distract and time pressure condition. All participants completed reading comprehension questions, demographic questions, and the Mindful Self-Regulated Learning Scale.

Results

Presenting a visual distraction increased self-reported distraction and having a clock present increased self-reported time pressure. The distraction did not have a statistically significant effect on test performance. Mindfulness was negatively correlated with test performance, self-reported distraction, and self-reported time pressure.

Discussion

Continuous task-irrelevant visual distractions may not be distracting enough to influence low-stakes testing performance, but they do influence self-perceptions.
Dual Lex: applying logistics strategies in the educational process
Authors: Khistyeva Daryna , Pócsová Jana
Published: August 2024

This article discusses the landscape of education. The challenge lies in harmoniously blending the directive PUSH strategies, which focus on structured guidance, with the exploratory PULL methods, centered around the learner's initiative. To illustrate this, the realms of science and art as examples are used, showcasing how these strategies can be interpreted and applied in different educational contexts. The educational systems of selected countries are considered from the viewpoint of the novel framework involving PUSH and PULL methodologies in the delivery of education. China's emphasis on a structured and orderly educational process, Finland's dedication to student autonomy and flexibility, and the UK's integrative, hybrid model. Nevertheless, there is still a need for a cohesive approach that effectively combines the structured science education methods with the more fluid and interpretative methods used in art education. This paper deals with a comparative analysis of how educational systems in China, Finland, and the UK navigate the PUSH-PULL dynamics. In this article, we propose and develop a new model for understanding the role of students in the educational system. This model, which we are introducing, views the student in a dual capacity: as both an integral part of the larger educational framework and as the primary consumer of state-provided knowledge. Our model aims to reframe the traditional perspective on students' roles in education. By introducing the “Dual Lex” concept, this study aims to merge (melt) two principal different educational models into a cohesive whole. The term “Dual” emphasizes the simultaneous use of these two methodologies, while “Lex” suggests a set of principles or rules governing this integration. Overall, this approach seeks to establish an educational framework that is as methodical and precise as it is creative and expressive, thereby equipping students with the skills and knowledge for a versatile and dynamic educational journey and more flexible and student-centered preparation for their future professional careers.
Connecting mathematics and sports in informal learning spaces
Authors: Turner Erin , Buxner Sanlyn , Miller Seneca B. , Baze Christina , Valerdi Ricardo
Published: August 2024

Introduction

There is a critical need to develop innovative educational strategies that engage youth in meaningful mathematics learning, particularly students from groups that have been historically marginalized in science, technology, engineering, and mathematics (STEM). In this study, we explore youths’ participation in two collaborative projects from the Growing Mathletes curriculum which combines baseball contexts and mathematics. Our goal was to understand the potential of these projects to support youths’ engagement with mathematical ideas and practices, and the extent to which youth leveraged a range of resources, including prior experiences and funds of knowledge, to inform their decisions and understanding.

Methods

The Design a Stadium and Baseball Team Roster projects were implemented in two afterschool setting sites and two summer program sites with 102 youth of all genders in grades 3 to 8. Data sources included video recordings of youth participation in the project, project artifacts, and youth interviews.

Results

We found the projects contained specific features that supported youths’ engagement in three specific mathematical practices: (1) make sense of problems and persevere in solving them, (2) reason abstractly and quantitatively, and (3) construct viable arguments and critique the reasoning of others. Additionally, there is evidence that while engaging in these projects youth drew on their own funds of knowledge to inform their decisions and understanding.

Conclusion

Our findings point to key implications for researchers, educators, and curriculum developers in informal STEM learning spaces.
Neutrophil-to-lymphocyte ratio as a predictor of all-cause and cardiovascular mortality in coronary heart disease and hypertensive patients: a retrospective cohort study
Authors: Song Songhong , Chen Liwen , Yu Rong , Zhu Jinxiu
Published: August 2024

Background

To date, no studies have investigated the correlation between the neutrophil-to-lymphocyte ratio (NLR) and the long-term risk of mortality in individuals with both coronary heart disease (CHD) and hypertension. This study aims to evaluate the association between NLR and all-cause and cardiovascular mortality among this patient population.

Methods

National Death Index (NDI) and National Health and Nutrition Examination Survey (NHANES 2001–2018) were the data sources. A nonlinear association between the NLR and mortality risk was shown by restricted cubic spline (RCS) analysis. Using a weighted Cox proportional hazards model, we quantitatively evaluated the effect of NLR on mortality risk.

The capacity of NLR to forecast survival was assessed by evaluating time-dependent receiver operating characteristic (ROC) curves. A mediating influence analysis was conducted to assess the influence of NLR on mortality through eGFR as a mediator.

Results

The study involved a total of 2136 individuals. During the median follow-up interval of 76.0 months, 801 deaths were recorded. The RCS analysis showed NLR and mortality risk to have a nonlinear relationship. Two groups were established based on the participants’ NLR levels: a group with high NLR (NLR > 2.65) and a group with low NLR (NLR < 2.65). After adjusting for potential confounding factors, the Cox proportional hazards model revealed that participants with an increased NLR faced a significantly higher risk of cardiovascular mortality. (HR 1.58, 95% CI 1.33–1.82, p < 0.0001) and all-cause mortality (HR 1.46, 95% CI 1.30–1.62, p < 0.0001). An analysis of interactions and data stratification corroborated the validity of our findings. eGFR was identified as a partial mediator in the association between NLR and mortality rates, contributing 12.17% and 9.66% of the variance in all-cause and cardiovascular mortality, respectively. The predictive performance for cardiovascular mortality was quantified using ROC curves, with respective AUC values of 0.67, 0.65, and 0.64 for predictions over 3, 5, and 10 years. The AUC values for all-cause mortality were 0.66, 0.64, and 0.63 for the same time frames.

Conclusion

For patients with CHD and hypertension, an elevated NLR serves as an independent prognostic indicator for both all-cause and cardiovascular mortality.
Use of graphene oxide for the removal of norfloxacin and ceftriaxone antibiotics from aqueous solution: process optimization using response surface approach
Authors: Li Zhihui , Zhang Shuhang , Zhu Guina , Xing Jie
Published: August 2024

In this research, graphene oxide (GO) as an adsorbent was used to remove norfloxacin and ceftriaxone antibiotics from aqueous solutions. All environmental factors affecting removal (e.g., pH, adsorbent mass, contact time, and concentration) were optimized in a discontinuous system. The design of experiments and the optimization of variables were carried out using the response surface method (RSM). The results of the analysis of variance (ANOVA) and the regression coefficients of the quadratic terms indicated that the responses were significantly affected by all the studied variables (P < 0.05). Also, the quadratic polynomial model results corresponded to empirical data with a high coefficient of determination (i.e., R2 ˃ 0.99 for both antibiotics). Besides, the adjusted R2 (R2-adj ˃ 0.98 for both antibiotics) was close to R2 values, indicating a good and acceptable statistical model. According to the results, the optimal removal of antibiotics by GO occurs in conditions of pH of 8, 0.034 g of the adsorbent mass, a sonication time of 20 min, and a concentration of 25 mg L−1. In these conditions, the maximum removal efficiencies of ceftriaxone and norfloxacin were equal to 95.87% and 98.64%, respectively. GO was recovered in five adsorption/desorption processes, and the removal efficiency declined very slightly after using the adsorbent for five cycles. Therefore, it is concluded that GO is an efficient and acceptable adsorbent for removing ceftriaxone and norfloxacin from aqueous environments.
Regulatory role of N6-Methyladenosine on skeletal muscle development in Hu sheep
Authors: Jiang Junfang , Guo Liangyong , Huang Xin , Zheng Kaizhi , He Sangang , Shan Huili
Published: August 2024

N6-Methyladenosine (m6A) RNA modification plays an essential role in many biological processes. To investigate the regulatory role of m6A on the skeletal muscle development in Hu sheep, this study took newborn Hu sheep (b_B Group) and six-month-old Hu sheep (s_B Group) as the objects. MeRIP-seq and RNA-Seq analysis techniques were used to detect differentially methylated genes (DMGs) and differentially expressed genes (DEGs) in the longissimus dorsi muscle of Hu sheep at different months of age. Then, conjoint analysis was further employed to screen for key genes involved in skeletal muscle development that are modified by m6A and expressed by mRNA. According to the results of the MeRIP-seq analysis, there were 285 m6A differentially methylated peaks (DMPs) in total between b_B Group and s_B Group, with 192 significant upregulated peaks and 93 significant downregulated peaks. GO and KEGG analysis revealed that DMGs are mainly enriched in actin-binding, cellular transport, and metabolic pathways. According to the results of the RNA-seq analysis, there were 4,349 DEGs in total between b_B Group and s_B Group, with 2010 upregulated genes and 2,339 downregulated genes. DEGs are found to be mainly enriched in the regulation of actin cytoskeleton tissue, AMPK and FoxO signaling pathways, etc. The conjoint analysis demonstrated that 283 genes were both modified by m6A and expressed by mRNA. Among them, three genes relevant to muscle growth (RGMB, MAPK8IP3, and RSPO3) were selected as candidates for quantitative validation, and the results were in line with the sequencing results. The results mentioned above all suggest that m6A plays a certain role in the skeletal muscle development in Hu sheep.
Professionalism and associated factors among nurses working in Hawassa city public hospital, Sidama, Ethiopia
Authors: Abebe Boe Eyerusalem , Mekonnen Shiwangizaw , Fako Thomas , Aschale Wale Mastewal , Tade Meku , Tsega Chekol Aklile
Published: August 2024

Background

The foundation of the global healthcare system is nurses, and professionalism in nursing is a basic idea that helps patients, organizations, and people. Studies that have been published in Ethiopia, though, are limited, out-of-date, and poorly documented, especially when it comes to the study setting. Because of this, this study aimed to close a knowledge gap on the level of professionalism in public hospitals in Sidama, Ethiopia.

Objective

This study aimed to assess professionalism and associated factors among nurses working in Hawassa city public hospitals, Hawassa, Ethiopia.

Methods

An institutional-based cross-sectional study was conducted among nurses working in Hawassa city public hospital from June to July 2022. A computer-generated simple random sampling technique was used to select 413 study participants. The level of professionalism was assessed through a self-administered questionnaire, using the guidelines of the Registered Nurses Association of Ontario. All the loaded data using Epi-data version 4.6 were exported to a statistical package for social science. An ordinal logistic regression analysis was used to identify the associations between the outcome and predictor variables. The statistical significance of the factors influencing the outcome variable was declared in multivariate logistic regression analysis using an adjusted odds ratio at a 95% confidence interval with a p-value <0.05.

Results

A total of 405 nurses participated in the study, with a response rate of 98%. Of the total participants, more than half were females (55.3%). The level of professionalism was found to a moderate level. There was a strong link between completing their degree in a governmental institution, being part of a professional organization, serving for several years, and having a BSc or above qualification with a moderate level of professionalism.

Conclusion

We found a moderate level of professionalism among nurses working in the study setting. This suggests that the Regional Health Bureau should collaborate with other responsible bodies to develop various opportunities for nursing staff to increase their professionalism. The minister of health should be focused on private college nurses, nurses lacking the association, and the qualification of the profession.
A novel polysaccharide-based bioflocculant produced by Bacillus subtilis 35A and its application in the treatment of dye decolorization, heavy metal ion adsorption and meat product wastewater
Authors: Dai Jinping , Zhao Xingxiu , Mu Shengdong , Yang Qinghuan , Zhao Changqing , Zhao Zhifeng
Published: August 2024

Optimizing the fermentation process of microorganisms with exceptional bioflocculant-producing capabilities is crucial for the production of bioflocculants. The application of bioflocculants to various pollutants highlights their significant advantages in water treatment. Therefore, the culture conditions of Bacillus subtilis 35A with exceptional bioflocculant-producing capabilities were optimized. The bioflocculant (MBF) was obtained by alcohol percipitation from the fermentation supernatant, and its physicochemical properties were analyzed to explore its application in the treatment of dyes, heavy metal ions, and organic wastewater. The results indicate that, using cyclodextrin and yeast extract as carbon and nitrogen sources, after 48 h of fermentation at the initial pH, the bioflocculant (MBF-35A) yielded 10.47 g/L with a flocculation rate of 96.57% for kaolin suspension. The chemical analysis demonstrated that MBF-35A is mainly composed of polysaccharide (81.74%) and protein (16.42%). FITR and XPS analysis indicated that MBF-35A mainly contains major elements such as carbon, nitrogen, and oxygen, with functional groups (-OH, C-O, C-H, and C-O-C) that are beneficial for flocculation. MBF-35A exhibited a dye decolorization efficiency exceeding 95% and removed 41.05 and 48.93% of Cr6+ and Cu2+ ions, respectively. In meat wastewater treatment, the effective removal rates of ammonia nitrogen (26.87%), COD (51.16%), total nitrogen (37.76%), and total phosphorus (55.81%) highlight its potential in organic waste treatment. In brief, not only does MBF-35A exhibit efficient production and excellent flocculation performance as a bioflocculant, but it also shows significant biological and environmental benefits in dye, heavy metal ions, and organic wastewater treatment.
Pitch corrections occur in natural speech and are abnormal in patients with Alzheimer's disease
Authors: Subrahmanya Anantajit , Ranasinghe Kamalini G. , Kothare Hardik , Raharjo Inez , Kim Kwang S. , Houde John F. , Nagarajan Srikantan S.
Published: August 2024

Past studies have explored formant centering, a corrective behavior of convergence over the duration of an utterance toward the formants of a putative target vowel. In this study, we establish the existence of a similar centering phenomenon for pitch in healthy elderly controls and examine how such corrective behavior is altered in Alzheimer's Disease (AD). We found the pitch centering response in healthy elderly was similar when correcting pitch errors below and above the target (median) pitch. In contrast, patients with AD showed an asymmetry with a larger correction for the pitch errors below the target phonation than above the target phonation. These findings indicate that pitch centering is a robust compensation behavior in human speech. Our findings also explore the potential impacts on pitch centering from neurodegenerative processes impacting speech in AD.
Predicting the clinical prognosis of acute ischemic stroke using machine learning: an application of radiomic biomarkers on non-contrast CT after intravascular interventional treatment
Authors: Gu Hongxian , Yan Yuting , He Xiaodong , Xu Yuyun , Wei Yuguo , Shao Yuan
Published: August 2024

Purpose

This study aimed to develop a radiomic model based on non-contrast computed tomography (NCCT) after interventional treatment to predict the clinical prognosis of acute ischemic stroke (AIS) with large vessel occlusion.

Methods

We retrospectively collected 141 cases of AIS from 2016 to 2020 and analyzed the patients' clinical data as well as NCCT data after interventional treatment. Then, the total dataset was divided into training and testing sets according to the subject serial number. The cerebral hemispheres on the infarct side were segmented for radiomics signature extraction. After radiomics signatures were standardized and dimensionality reduced, the training set was used to construct a radiomics model using machine learning. The testing set was then used to validate the prediction model, which was evaluated based on discrimination, calibration, and clinical utility. Finally, a joint model was constructed by incorporating the radiomics signatures and clinical data.

Results

The AUCs of the joint model, radiomics signature, NIHSS score, and hypertension were 0.900, 0.863, 0.727, and 0.591, respectively, in the training set. In the testing set, the AUCs of the joint model, radiomics signature, NIHSS score, and hypertension were 0.885, 0.840, 0.721, and 0.590, respectively.

Conclusion

Our results provided evidence that using post-interventional NCCT for a radiomic model could be a valuable tool in predicting the clinical prognosis of AIS with large vessel occlusion.
Association between 35 blood and urine biomarkers and oral leukoplakia: a two-sample Mendelian randomization study
Authors: Ouyang Yu-long , Wei Jing , Liu Mei-yan , Zhang Yi , Liu Sheng-hui , Feng Hong-chao
Published: August 2024

Background

Several existing studies have shown a correlation between some of the blood and urine biomarkers and oral leukoplakia (OLK). However, the causality of this relationship remains uncertain. Thus, this study aimed to examine the causal association between 35 blood and urine biomarkers and OLK.

Methods

Single nucleotide polymorphisms (SNPs) associated with 35 blood and urine biomarkers were selected as instrumental variables (IVs) using a two-sample Mendelian randomization(MR) study to assess the causal relationship between the biomarkers and the risk of oral leukoplakia. We used the inverse variance weighted (IVW) method as the main analysis. Furthermore, several sensitivity analyses were performed to assess heterogeneity, horizontal pleiotropy, and stability.

Results

Based on the selection criteria of the Inverse Variance Weighted (IVW) method, the analysis found that 5 blood and urine biomarkers were significantly associated with the development of leukoplakia, of which the results of IVW showed that abnormalities of Apolipoprotein B (Apo B), Cholesterol, Low-density Lipoprotein (LDL), Triglycerides (TG) promoted the development of oral leukoplakia, and Non Albumin Protein (NAP) had a protective effect on the development of oral leukoplakia. We then performed a Bonferroni correction for these results, and after correction Apo B was still causally associated with the development of oral leukoplakia (IVW P<0.0007), whereas the other four biomarkers could only provide some evidence of predisposition.

Conclusion

Our two-sample Mendelian randomization study supports the existence of a causal relationship between these five blood and urine biomarkers and the occurrence of oral leukoplakia, and provides evidence for a number of risk and protective factors for the development of oral leukoplakia; however, the definitive mechanisms for the occurrence and development of oral leukoplakia still remain to be elucidated, and further studies on these relevant mechanisms are still needed.
Pharmacological profile of dicaffeoylquinic acids and their role in the treatment of respiratory diseases
Authors: Hufnagel Matthias , Rademaekers André , Weisert Anika , Häberlein Hanns , Franken Sebastian
Published: August 2024

Dicaffeoylquinic acids (DCQAs) are polyphenolic compounds found in various medicinal plants such as Echinacea species and Hedera helix, whose multi-constituent extracts are used worldwide to treat respiratory diseases. Besides triterpenes, saponins, alkamides, and other constituents, DCQAs are an important group of substances for the pharmacological activity of plant-derived extracts. Therefore, the pharmacological properties of DCQAs have been studied over the last decades, suggesting antioxidative, anti-inflammatory, antimicrobial, hypoglycaemic, cardiovascular protective, neuroprotective, and hepatoprotective effects. However, the beneficial pharmacological profile of DCQAs has not yet been linked to their use in treating respiratory diseases such as acute or even chronic bronchitis. The aim of this review was to assess the potential of DCQAs for respiratory indications based on published in vitro and in vivo pharmacological and pre-clinical data, with particular focus on antioxidative, anti-inflammatory, and respiratory-related effects such as antitussive or antispasmodic properties. A respective literature search revealed a large number of publications on the six DCQA isoforms. Based on this search, a focus was placed on 1,3-, 3,4-, 3,5-, and 4,5-DCQA, as the publications focused mainly on these isomers. Based on the available pre-clinical data, DCQAs trigger cellular mechanisms that are important in the treatment of respiratory diseases such as decreasing NF-κB activation, reducing oxidative stress, or activating the Nrf2 pathway. Taken together, these data suggest an essential role for DCQAs within herbal medicines used for the treatment of respiratory diseases and highlights the need for the identifications of DCQAs as lead substances within such extracts.
Assessment of executive functions using a 3D-video game in children and adolescents with ADHD
Authors: Takahashi Nagahide , Ono Tomihiro , Omori Yuka , Iizumi Misuzu , Kato Hidekazu , Kasuno Shinichi , Persing Barry , Tsuchiya Kenji J.
Published: August 2024

Objective

Executive functions are important factors that affect the well-being of children with ADHD. Therefore, inclusion of a convenient assessment of executive dysfunction in diagnosis and treatment of ADHD patients is warranted. However, executive dysfunction assessment presently relies on lab-based neuropsychological tests and symptom rating scales. The present study examined the potential of a 3-D action puzzle video game to reflect ecologically valid executive functioning in pediatric ADHD patients.

Methods

Participant gameplay metrics were compared to both their Cambridge Neuropsychological Test Automated Battery (CANTAB) and Conners 3 Parent Form’s executive functioning subscale scores. Participants consisted of 33 ADHD and non-ADHD patients aged 8-21.

Results

Metrics from gameplay were associated with distinct CANTAB test scores, and a composite score from gameplay was significantly correlated with executive dysfunction from Conners 3.

Conclusion

For children with ADHD, cognitive domains related to executive function and overall real-life executive functioning appear to both be measurable via video games. It may be possible to develop individualized behavioral therapy based on the quantitative data obtained from the video game used in this study.
Positive cardiovascular health: longitudinal investigation of sustained health behavior in a cross-lagged model
Authors: Ocsovszky Zsofia , Ehrenberger Blanka , Berenyi Blanka , Assabiny Alexandra , Otohal Jozsef , Martos Tamas , Papp-Zipernovszky Orsolya , Hegedus Fanni , Merkely Bela , Csabai Marta , Bagyura Zsolt
Published: August 2024

Objective

Our study focuses on the role of psychological states in the development of cardiovascular disease (CVD) and explores the potential of positive psychological factors in reducing CVD risk. While existing research has predominantly examined negative mental states and risk behavior, this longitudinal study takes a novel approach by investigating positive psychological wellbeing and its impact on sustained health behavior.

Method

The research involved participants (n = 502) with medium to high cardiovascular risk who underwent a comprehensive risk assessment in 2012, followed by written risk communication. Health behavior and psychological variables were measured in 2012 and 2019. A cross-lagged panel was employed to repeat measures of a cardiovascular health index with latent factors.

Results

Results indicated an excellent fit for the model (RMSEA = 0.0644, CFI = 0.936, TLI = 0.921, SRMR = 0.050), with significant associations between the observed variables (p < 0.05) and created latent factors. Furthermore, the model implied significant bivariate correlations (p < 0.05) between latent constructs of sustained health behavior and positive psychological states in 2012 and 2019. A significant regression relationship between Health Awareness Index 2012 and 2019, between Psychological wellbeing in 2012 and 2019 (B = 1.103 p = 0.038), latent factors could be identified (B = 1.103 p = 0.038) using cross-lagged panel model. Results highlighted the importance of cardiovascular health awareness, subjective risk perception, and self-directed efforts in facilitating health behavior change.

Conclusion

Relationships between psychological wellbeing and health awareness emphasize that positive experiences and reinforcement are crucial in sustaining optimal health behavior. Our findings offer a new perspective on cardiovascular risk screening and preventive interventions. Extending cardiovascular risk screening with psychological measures may broaden prevention opportunities by including psychological elements reinforcing positive psychological states. The findings suggest that an effective prevention program must consider stabilizing and maintaining positive psychological states to achieve lasting improvements in cardiovascular health.
Association between long-term exposure to PM2.5 chemical components and metabolic syndrome in middle-aged and older adults
Authors: Zhang Jingjing , Zhang Jinglong , Duan Zhizhou , Nie Jing , Li Xiangyu , Yu Wenyuan , Niu Zhiping , Yan Yangjin
Published: August 2024

Background

Previous studies indicated that exposure to ambient fine particulate matter (PM2.5) could increase the risk of metabolic syndrome (MetS). However, the specific impact of PM2.5 chemical components remains uncertain.

Methods

A national cross-sectional study of 12,846 Chinese middle-aged and older adults was conducted. Satellite-based spatiotemporal models were employed to determine the 3-year average PM2.5 components exposure, including sulfates (SO42−), nitrates (NO3−), ammonia (NH4+), black carbon (BC), and organic matter (OM). Generalized linear models were used to investigate the associations of PM2.5 components with MetS and the components of MetS, and restricted cubic splines curves were used to establish the exposure-response relationships between PM2.5 components with MetS, as well as the components of MetS.

Results

MetS risk increased by 35.1, 33.5, 33.6, 31.2, 32.4, and 31.4% for every inter-quartile range rise in PM2.5, SO42−, NO3−, NH4+, OM and BC, respectively. For MetS components, PM2.5 chemical components were associated with evaluated risks of central obesity, high blood pressure (high-BP), high fasting glucose (high-FBG), and low high-density lipoprotein cholesterol (low-HDL).

Conclusion

This study indicated that exposure to PM2.5 components is related to increased risk of MetS and its components, including central obesity, high-BP, high-FBG, and low-HDL. Moreover, we found that the adverse effect of PM2.5 chemical components on MetS was more sensitive to people who were single, divorced, or widowed than married people.
An examination of mental health policy implementation efforts and the intermediaries that support them in New Zealand, Canada and Sweden: a comparative case study
Authors: Bullock Heather L. , Lavis John N. , Mulvale Gillian , Wilson Michael G.
Published: August 2024

Introduction

The implementation of evidence-informed policies and practices across systems is a complex, multifaceted endeavor, often requiring the mobilization of multiple organizations from a range of contexts. In order to facilitate this process, policy makers, innovation developers and service deliverers are increasingly calling upon intermediaries to support implementation, yet relatively little is known about precisely how they contribute to implementation. This study examines the role of intermediaries supporting the implementation of evidence-informed policies and practices in the mental health and addictions systems of New Zealand, Ontario, Canada and Sweden.

Methods

Using a comparative case study methodology and taking an integrated knowledge translation approach, we drew from established explanatory frameworks and implementation theory to address three questions: (1) Why were the intermediaries established? (2) How are intermediaries structured and what strategies do they use in systems to support the implementation of policy directions? and (3) What explains the lack of use of particular strategies? Data collection included three site visits, 49 key informant interviews and document analysis.

Results

In each jurisdiction, a unique set of problems (e.g., negative events involving people with mental illness), policies (e.g., feedback on effectiveness of existing policies) and political events (e.g., changes in government) were coupled by a policy entrepreneur to bring intermediaries onto the decision agenda. While intermediaries varied greatly in their structure and characteristics, both the strategies they used and the strategies they didn't use were surprisingly similar. Specifically it was notable that none of the intermediaries used strategies that directly targeted the public, nor used audit and feedback. This emerged as the principle policy puzzle. Our analysis identified five reasons for these strategies not being employed: (1) their need to build/maintain healthy relationships with policy actors; (2) their need to build/maintain healthy relationships with service delivery system actors; (3) role differentiation with other system actors; (4) perceived lack of “fit” with the role of policy intermediaries; and (5) resource limitations that preclude intensive distributed (program-level) work.

Conclusion

Policy makers and implementers must consider capacity to support implementation, and our study identifies how intermediaries can be developed and harnessed to support the implementation process.
Dynamics and socio-environmental impacts of mopane worm harvesting in rural communities in Zimbabwe: prospects for climate-smart approaches
Authors: Dube Susan Samukele , Chitakira Munyaradzi
Published: August 2024

Rural communities in parts of Botswana, Namibia, South Africa, and Zimbabwe rely heavily on mopane worms (imbrasia belina) as a livelihood, particularly during times when the households have limited livelihood options. While mopane worms are a vital source of protein and income for rural communities, climate change and variability are putting the sustainability of this vital natural resource under threat. As such, a critical evaluation of the harvesting methods and the associated dynamics is necessary to establish ways of sustaining this resource. This study thus sought to examine the existing mopane worm harvesting practices and evaluate their viability in the wake of climate change and variability. The study focused on Garanyemba Ward 13 of Gwanda District in south-western Zimbabwe. It assessed the harvesting practices and their impact on the environment and the sustainability of mopane worm populations. A qualitative research approach involving participant observation, focus group discussions, and interviews was employed. The findings show that the harvesting of mopane worms in the area was achieved predominantly through climbing up or shaking the trees, plucking worms from branches, and gathering worms that would otherwise be crawling on the ground. Socio-environmental impacts of the existing methods of harvesting revealed include vegetation damage leading to decreased mopane woodland densities, the emergence of squatter communities during outbreak times and the associated land pollution. The study concludes that the influx of foreign harvesters, which eventually exposed the habitat of mopane worms over-harvesting was attributed to limited institutional control. The study recommends control of harvesters by strick enforcement of regulatory frameworks, adherence to selective harvesting to ensure the preservation of worms for future production.