bluuebunny/crossref_metadata_2025 huggingface dataset:
„Cywilizacja? Puste słowo”. Antycywilizacjonizm w polskim podróżopisarstwie międzywojennym
Authors:   Wydział Filologii Polskiej i Klasycznej, Uniwersytet im. Adama Mickiewicza w Poznaniu, Paczkowski Mikołaj
Published: September 2023

The article discusses the criticism of civilization presented in the interwar travel literature. The author points out that the critical attitude towards European civilization is directly related to the modernist paradigm. Interwar writers-travellers express their views using existing rhetorical figures, treating the modern city as a metonymy of civilization. Therefore, they use simple contrasts, such as culture-nature, disease-health, old age-youth, dirt-cleanliness, etc. They seek escape from civilization on the city outskirts or in places perceived as exotic. Tadeusz Dębicki and Kazimierz Nowak combine anti-civilization attitudes with anti-colonial views, unlike Ferdynand Ossendowski, who, while critical of the situation in Europe, simultaneously expresses his enthusiasm for the actions of the colonizers.
„To jest weryfikacja rzeczywistości”. Narracja drugoosobowa w fantastyce naukowej
Authors:   Kolegium Literaturoznawstwa, Wydział Filologiczny, Uniwersytet w Białymstoku, Leś Mariusz M.
Published: September 2023

The article contains an analysis of the function of second-person narrative in selected works of science fiction. This experimental type of narrative is characterised by a tendency to blur the line between the fictional and non-fictional worlds and to strengthen the reader’s empathic attitude. As the article shows, the combination of the possibility of deepening the psychological images of fictional characters with the complication of the ontological hierarchy of worlds and undermining their stability leads to interesting effects. Among them, the most promising seems the potential for strengthening the meanings that result from the confrontation of subjective worlds with the fictional worlds, understood as arenas for the characters’ actions.
A method to detect fulvestrant interference in estradiol in breast cancer patients
Authors: Brito Margarida , Prazeres Susana , Malheiros Marta
Published: September 2023

Background

Fulvestrant resembles estradiol in its structure. Reports have been published concerning fulvestrant measured as estradiol by the immunoassays. This may induce falsely elevated estradiol results and wrongly impact medical decisions. Our aim was to confirm the interference of fulvestrant on estradiol concentration and test a method to identify the false results.

Methods

Four serum samples with low estradiol levels were spiked with fulvestrant at various concentrations. Estradiol was then measured directly on serum (Dir), after a 1:5 dilution (Dil), and a ratio Dil/Dir was estimated. On the second part of the study, estradiol results (Dir, Dil and ratio Dil/Dir) from 14 women treated with fulvestrant were analysed, as well as from 14 patients not under this treatment.

Results

The addition of exogenous fulvestrant to the serum samples induced a gradual rise on estradiol concentration with a mean ratio for the Dil/Dir samples of 2.1 ± 0.4 (range 1.7–2.9). Patients on fulvestrant treatment experienced a mean ratio for the Dil/Dir estradiol sample of 2.4 ± 0.4 (range 1.6–3.0). In the control group, a mean estradiol ratio Dil/Dir of 1.1 ± 0.1 was observed (range 0.8–1.3). No correlation between the number of days after fulvestrant injection and estradiol result (r = 0.531) was observed.

Conclusion

Our study confirmed the interference of fulvestrant in the estradiol measurement by immunoassay. When fulvestrant was present, the estradiol ratio for Dil/Dir sample was about 2. In the control group, the ratio was around 1. The estradiol Dil/Dir ratio is a simple tool which can be used to identify fulvestrant false immunoassay estradiol results.
ThyroidPrint®: clinical utility for indeterminate thyroid cytology
Authors: Olmos Roberto , Domínguez José Miguel , Vargas-Salas Sergio , Mosso Lorena , Fardella Carlos E , González Gilberto , Baudrand René , Guarda Francisco , Valenzuela Felipe , Arteaga Eugenio , Forenzano Pablo , Nilo Flavia , Lustig Nicole , Martínez Alejandra , López José M , Cruz Francisco , Loyola Soledad , Leon Augusto , Droppelmann Nicolás , Montero Pablo , Domínguez Francisco , Camus Mauricio , Solar Antonieta , Zoroquiain Pablo , Roa Juan Carlos , Muñoz Estefanía , Bruce Elsa , Gajardo Rossio , Miranda Giovanna , Riquelme Francisco , Mena Natalia , González Hernán E
Published: September 2023

Molecular testing contributes to improving the diagnosis of indeterminate thyroid nodules (ITNs). ThyroidPrint® is a ten-gene classifier aimed to rule out malignancy in ITN. Post-validation studies are necessary to determine the real-world clinical benefit of ThyroidPrint® in patients with ITN. A single-center, prospective, noninterventional clinical utility study was performed, analyzing the impact of ThyroidPrint® in the physicians’ clinical decisions for ITN. Demographics, nodule characteristics, benign call rates (BCRs), and surgical outcomes were measured. Histopathological data were collected from surgical biopsies of resected nodules. Of 1272 fine-needle aspirations, 109 (8.6%) were Bethesda III and 135 (10.6%) were Bethesda IV. Molecular testing was performed in 155 of 244 ITN (63.5%), of which 104 were classified as benign (BCR of 67.1%). After a median follow-up of 15 months, 103 of 104 (99.0%) patients with a benign ThyroidPrint® remained under surveillance and one patient underwent surgery which was a follicular adenoma. Surgery was performed in all 51 patients with a suspicious for malignancy as per ThyroidPrint® result and in 56 patients who did not undergo testing, with a rate of malignancy of 70.6% and 32.1%, respectively. A higher BCR was observed in follicular lesion of undetermined significance (87%) compared to atypia of undetermined significance (58%) (P < 0.05). False-positive cases included four benign follicular nodules and six follicular and four oncocytic adenomas. Our results show that, physicians chose active surveillance instead of diagnostic surgery in all patients with a benign ThyroidPrint® result, reducing the need for diagnostic surgery in 67% of patients with preoperative diagnosis of ITN.
СУЧАСНЕ ДИСТАНЦІЙНЕ НАВЧАННЯ ЯК ЗАПОРУКА ФОРМУВАННЯ ОСОБИСТІСНИХ І ПРОФЕСІЙНИХ ЯКОСТЕЙ
Authors: БРІЛЛІАНТОВ АНТОН
Published: September 2023

У статті висвітлено особливості впровадження дистанційного навчання в контексті формування та розвитку особистісних і професійних якостей. Визначено, що в умовах дистанційного навчання особистість здатна не лише до опанування нового, а й формування та вдосконалення якостей, які необхідні для саморозвитку й самоосвіти, професійної діяльності. Висвітлено ключові особистісні і професійні якості, які можна розвинути в умовах дистанційного навчання. Обґрунтовано шляхи формування та розвитку якостей особистості під час дистанційної форми навчання.
ПСИХОЛОГО-ПЕДАГОГІЧНІ ОСНОВИ ЗАСТОСУВАННЯ ІНТЕГРОВАНОГО НАВЧАННЯ В ОСВІТНІЙ СФЕРІ
Authors: ОВДІЙЧУК ЛІЛІЯ
Published: September 2023

У статті репрезентовано ретроспективний аналіз наукових праць, у яких виявлено інтеграційні ідеї та узагальнено основні психолого-педагогічні засади інтеграції у навчанні як елемента розвитку, умови цілісності, процесу організації, способу реалізації мети, засобу досягнення інтегрованого результату. Аргументовано доведено, що інтегроване навчання – це навчання за інтеграційним принципом, яке ґрунтується на змістовій та діяльнісній інтеграції. Освіта, заснована на інтеграції, має системний характер і є ґрунтом для формування у здобувачів цілісного світогляду та ключових і предметних компетентностей.
ЕКСПЕРИМЕНТАЛЬНА ПЕРЕВІРКА ЕФЕКТИВНОСТІ ПЕДАГОГІЧНИХ УМОВ ФОРМУВАННЯ ЗДОРОВ’ЯЗБЕРЕЖУВАЛЬНОЇ КОМПЕТЕНТНОСТІ МАЙБУТНІХ УЧИТЕЛІВ ПОЧАТКОВИХ КЛАСІВ
Authors: БАЛУХ МИКОЛА
Published: September 2023

У статті зроблено акцент, що професійна підготовка майбутніх учителів початкових класів неможлива без формування їхньої здоров’язбережувальної компетентності, що значною мірою залежить від визначення рівнів їхніх фахових компетентностей і відповідних критеріїв. Доведено, що оцінювання рівнів фахових компетентностей майбутнього вчителя є суб’єктивним і відображає позицію дослідника означеної проблеми.

Авторами розкрито хід експериментальної перевірки педагогічних умов формування здоров’язбережувальної компетентності майбутніх учителів початкових класів у процесі професійної підготовки в педагогічному закладі вищої освіти. Розкрито компоненти і критерії сформованості відповідних рівнів здоров’язбережувальної компетентності, визначено три рівні розвитку останньої.

Встановлено, що здоров’язбережувальна компетентність розвивається від одного рівня до іншого, а її  діагносттика здійснюється відповідно до структури, показників і критеріїв визначення рівнів сформованості її компонентів.
ОГЛЯД ОСНОВНИХ ВИДІВ, МЕТОДІВ І ЗАСОБІВ ОЦІНЮВАННЯ НА УРОКАХ АНГЛІЙСЬКОЇ МОВИ
Authors: БОЙКО ОКСАНА
Published: September 2023

Стаття присвячена проблемі оцінювання на уроках англійської мови. Розкрито теоретичні аспекти основних видів оцінювання. Висвітлено результати українських досліджень щодо основних видів, методів і засобів оцінювання в рамках концепції НУШ. Оглянуто зарубіжні дослідження проблеми оцінювання. Проаналізовано навчальні посібники з англійської мови британських видавництв з грифом МОН України. Порівняно можливості для оцінювання, які надають посібники Express Publishing, MM Publication, Cambridge, Pearson та Macmillan. Описано застосування основних видів і методів оцінювання засобами деяких навчальних посібників згаданих вище видавництв.
ПЕДАГОГІЧНИЙ ПОТЕНЦІЯЛ ВІДОМОСТЕЙ ПРО СТВОРЕННЯ І ПОБУТУВАННЯ ПСАЛТИРЯ В «ІСТОРІЇ УКРАЇНСЬКОЇ ЛІТЕРАТУРИ» МИХАЙЛА ГРУШЕВСЬКОГО
Authors: КІНДРАТЮК БОГДАН
Published: September 2023

Уперше розглянуто педагогічний потенціял відомостей про створення і побутування Псалтиря в шеститомній “Історії української літератури” М. Грушевського. Вони згадані серед інформації про музику. Упорядковані факти підтверджують розвій духовності нашого народу, оригінальність у трактуванні інтернаціонального матеріялу, допомагають краще усвідомити внесок у світову культуру, зокрема, справу популяризації Біблії, інтерпретації її відомостей.
СТАВЛЕННЯ СТУДЕНТІВ ДО РІЗНИХ ФОРМ ОРГАНІЗАЦІЇ НАВЧАННЯ
Authors: ГУРАЛЬ ІНЕСА , СМОЛОВИК ЛІАНА
Published: September 2023

У статті проаналізовано  результати опитування студентів  Івано-Франківського національного технічного університету нафти і газу (ІФНТУНГ)  щодо  використання різних форм організації навчання: традиційного очного, змішаного та дистанційного. Зроблено висновки про те, що пріоритетні формати навчання студентів відрізняються як для різних напрямів підготовки, так і різних вікових категорій. Авторами доведено, що студенти різних напрямів підготовки мають подібні погляди щодо вибору організації навчання для більшості дисциплін, за винятком математики та іноземної мови, а студенти молодших курсів для вивчення більшості дисциплін надають перевагу очному та змішаному форматам, а старших курсів – дистанційному. Узагальнено, що вибір студентами оптимального формату навчання залежить від усіх досліджених ознак.
ОРГАНІЗАЦІЙНО-ПЕДАГОГІЧНІ УМОВИ РЕАЛІЗАЦІЇ ПІДГОТОВКИ ВИКЛАДАЧА ПРАВА В ЗАКЛАДІ ВИЩОЇ ОСВІТИ
Authors: КРИШТАНОВИЧ МИРОСЛАВ , ВОВЧАСТИЙ КІНДРАТ
Published: September 2023

У статті розкрито сутність організаційно-педагогічних умов реалізації процесу підготовки викладачів права. З’ясовано, що різновиди педагогічних умов пов’язані з особливостями організації освітнього процесу у ЗВО і відображають його функціональну залежність від внутрішніх і зовнішніх чинників. Визначено оптимальні організаційно-педагогічні умови для навчання та підготовки викладачів права: спрямування на самореалізацію особистості за допомогою створення і підтримки інновацій в освітньому середовищі; реалізація методичних умінь і навичок у майбутніх викладачів права, забезпечення розвитку їх професійних якостей; мотивація до навчальної діяльності і розвиток пізнавальної активності. Доведено, що процес підготовки майбутніх викладачів права має розглядатися як цілісна педагогічна система, що утворюється на основі взаємодії її структурно-функціональних компонентів, що забезпечують якість формування професійної підготовки майбутніх викладачів права.
РОЗВИТОК ТВОРЧИХ ЗДІБНОСТЕЙ СТУДЕНТІВ МИСТЕЦЬКИХ СПЕЦІАЛЬНОСТЕЙ У ПРОЦЕСІ ВИКОНАННЯ НАЧЕРКІВ І ЗАМАЛЬОВОК З НАТУРИ
Authors: МОЗОЛЮК ОЛЕНА
Published: September 2023

У статті на основі аналізу психолого-педагогічних досліджень окреслено основні умови розвитку творчих здібностей у студентів мистецьких закладів; розглянуто особливості створення начерків і замальовок; висвітлено основний принцип виконання практичних робіт в образотворчому мистецтві (від загального до конкретного і від конкретного до загального); подано основні вимоги до виконання начерків і замальовок; розкрито значення графічних матеріалів у процесі виконання начерків і замальовок.
РОЗВИТОК ЧИТАЦЬКОЇ КОМПЕТЕНТНОСТІ УЧНЯ: ЧИТАЄМО СМИСЛИ, ВІДТВОРЮЄМО МОДЕЛІ СВІТУ ТА ПОВЕДІНКИ ПЕРСОНАЖІВ, РОЗВИВАЄМО ЦІННІСНЕ СТАВЛЕННЯ ДО ЖИТТЯ
Authors: ОСТРОВСЬКА ГАЛИНА
Published: September 2023

У статті розглянуто питання впровадження компетентнісного підходу до вивчення художньої літератури у школі. Проаналізовано дослідження сучасних науковців з формування читацької компетентності учнів. Зроблено спробу надання вчителю ключів-підказок для мотивації учнів до читання, пошуку соціокультурних смислів, їх інтерпретації. Розкрито психологічний аспект читання: він полягає в тому, що фундаментом твору як емоційно-вольової діяльності письменника та сприймання читача є їх емоційно-ціннісна сфера, соціоемоційні навички. Запропоновано завдання на пошук смислів, алгоритм роботи над прочитаним, читацькі ключі для роботи з текстом (емоційні смисли, реконструкція авторської моделі світу та поведінки персонажів, «примірювання» смислів і засвоєння особистісно значимого).
Young adults in flux: The role of dimensions of emerging adulthood and psychological capital in the intention to remain in an organization
Authors: Kačmár Pavol , Baranyiová Daniela , Zentková Lenka
Published: September 2023

Objective. Research dedicated to turnover intentions has proliferated in the last decades, identifying various predictors of intention to voluntarily quit the organization. However, although previous studies indicated that younger employees are more prone to turnover intentions, emerging adulthood, as a specific developmental period, has been neglected in previous research dedication to turnover intentions. Emerging adulthood corresponds to ages 18–29 years, during which individuals consider themselves as no longer adolescents, but not yet as full‑fledged adults. Besides the achievement of developmental milestones, various psychologically based qualities – known as dimensions of emerging adulthood – are differentiated in a research literature, and can play a role in turnover intentions. Relatedly, although Psychological capital (PsyCap) – as a second‑order construct integrating hope, self‑efficacy, resilience, and optimism - has been established as a correlate of intention to remain in the organization in previous studies, the role of positive psychological resources in intention to stay in an organization during emerging adulthood, as a specific developmental period, has been neglected. Moreover, recent literature also indicates that the relationship between psychological capital and turnover intention could be indirect – i.e., mediated by other variables such as work engagement – and that a similar pattern of results could be expected also in the case of dimensions of emerging adulthood. Thus, the aim of the present paper is to examine the role of (A) dimensions of emerging adulthood (as potentially important developmental factors) and (B) psycho‑ logical capital (as a positive psychological state that could be purposefully cultivated) in the intention to remain in the organization both directly, and indirectly (i.e., potentially mediated via work engagement).
Hacia nuevos horizontes rítmicos de lo educativo. Una aproximación ecocrítica a la obra teatral Terrenal
Authors: Cosentino Pablo
Published: September 2023

En este trabajo, se hace una reflexión en torno a una filosofía de la educación centrada en la percepción de ritmos acordes con formas de relación con el ambiente, basadas en el cuidado hacia la vida. En esta dirección, se realiza un análisis ecocrítico de la obra Terrenal. Pequeño misterio ácrata (2014) de Mauricio Kartun, la cual permite teorizar sobre la relevancia de la atención a los ritmos, los pulsos y las armonías de textos literarios (y otros formatos artísticos) en la construcción de propuestas educativas que aspiren a dislocar la lógica expansiva propia de las actuales sociedades del capitalismo globalizado. El análisis crítico de esta cuestión es de especial relevancia a la hora de vislumbrar modos de vida alternativos que puedan relacionarse, de manera más armónica, con las escalas y las proporciones emergentes de la interacción entre la multiplicidad de existencias que conforman un territorio de vida.
Positivismo y reforma universitaria en Honduras durante el Gobierno de Marco Aurelio Soto (1876-1883)
Authors: Cardona Amaya José Manuel
Published: September 2023

Este artículo expone la reforma universitaria basada en el positivismo que fue conducida por el Gobierno de Marco Aurelio Soto (1876-1883) en Honduras. Su objetivo es demostrar cómo los reformadores plantearon la filosofía positiva como un avance, en comparación al modelo humanista que anteriormente tenía la Universidad hondureña, y cómo esta corriente de pensamiento se plasmó en el Código de Instrucción Pública de 1882. Se utilizaron fuentes originales de la época, mediante las cuales fue posible mostrar los argumentos que esgrimieron los reformadores para adoptar el modelo positivista. Finalmente, se concluye que la reforma universitaria impulsada por los reformadores liberales en Honduras fracasó y el modelo enfrentó reformas y reajustes en los años inmediatos a su imposición.
Primera persona del singular de Haruki Murakami. Relatos crepusculares y rastros autobiográficos
Authors: Castellón Alcalá Heraclia
Published: September 2023

El volumen Primera persona del singular –aparecido en 2020– acoge ocho relatos breves de Murakami que permiten descubrir temas ya tratados en su repertorio: desconcierto vital, episodios desairados de una juventud infeliz, la irrupción de lo fantástico, la impostura. Comprobar cómo se plasman los temas planteados y el formato textual seleccionado es el objetivo de este trabajo. Además de constatar su vínculo con las obras anteriores, importa al mismo tiempo reconocer qué nuevo aporte ofrece este conjunto cuentístico, por lo que se ha atendido a reseñar los nuevos territorios que se recorren. Destaca señaladamente aquí el tono desde el que se narra, ahora ya el de la edad avanzada. Encontramos así que reflexiona sobre la vecindad de la muerte inexorable, que también presenta códigos de principios morales, todo siempre desde la perspectiva de una primera persona del singular desde la cual Murakami parece darnos a un tiempo pistas personales y otras ficticias, con la apariencia de verdad que le ofrece el género japonés de Novelas del yo, al que de algún modo se remite.
Aspectos ortográficos, fonéticos y gramaticales en manuscritos del prócer independentista chileno José Miguel Carrera
Authors: Almau Almau Sonia
Published: September 2023

En este artículo se analizan los aspectos ortográficos, fonéticos y gramaticales más significativos de dos manuscritos de J. M. Carrera, ilustre prócer de la independencia chilena. Sus escritos –su extenso Diario Militar (1810-1814) y la Libreta que dejó antes de morir fusilado– nos permiten adentrarnos en un momento convulso ideológicamente en el que no solo está cambiando la historia, sino también la lengua. Además de aspectos lingüísticos que podemos explicar por una mera cuestión diacrónica, estos manuscritos arrojan rasgos innovadores que muestran cómo la lengua está adquiriendo rasgos propios al otro lado del Atlántico.
La lógica del ritmo: apuntes para una clasificación de las lecturas de Piedra de sol de Octavio Paz
Authors: López Soto Luis Alberto
Published: September 2023

Piedra de sol (1957) del poeta mexicano Octavio Paz es un poema extenso. Desde su publicación hasta la actualidad ha sido objeto de diversas lecturas. En el presente artículo se hace un análisis del poema y, sobre todo, una descripción, análisis y clasificación de las lecturas aportadas por la crítica especializada con el objetivo de trazar una directriz que explique la lógica y evolución de tales interpretaciones. Se utilizan los conceptos teóricos de inmanencia y trascendencia para exponer cronológicamente aquellas lecturas que observan en el texto de Paz un manifiesto poético de una estructura verbal o un discurso (filosófico, religioso, antropológico, etcétera) extratextual, o la fusión de estas dos lecturas. Todo esto para proponer que la noción de ritmo (encontrada en las últimas lecturas del poema) es una clave analítica e interpretativa que cohesiona lo inmanente y lo trascendente, y representa, por lo tanto, un punto cúspide de la crítica.
Some Stability and Exact Results in Generalized Turán Problems
Authors: Gerbner Dániel
Published: September 2023

Given graphs H and F, the generalized Turán number ex(n, H, F) is the largest number of copies of H in n-vertex F-free graphs. Stability refers to the usual phenomenon that if an n-vertex F-free graph G contains almost ex(n, H, F) copies of H, then G is in some sense similar to some extremal graph. We obtain new stability results for generalized Turán problems and derive several new exact results.
ReOrienting Religion?
Authors: Salvatore Armando , Obuse Kieko
Published: September 2023

This study presents a case of East–West entanglement not confined to dynamics internal to the Western trajectory of production and critique of Eurocentric notions of religion. It explores how the critical opening initiated by Wilfred Cantwell Smith in 1962 against reifying “religion” cannot be treated exclusively as an antecedent to the critical genealogy of religion performed by Talal Asad. We suggest that it needs to be read in the context of Smith’s collaboration with Toshihiko Izutsu, whose approach possessed a stronger counterhegemonic potential than the genealogists’ interventions in the critique of religion, which are still inscribed within a Western conceptual compass. We argue that thanks to his original skills as a philosopher of language, Izutsu put to better fruition Smith’s embryonic approach to the power-fraught character of language and discourse by studying Islamic traditions semantically, discursively, and contextually.
Gayatri in the Modern Era
Authors: Dalal Neil
Published: September 2023

The Gayatri is a ubiquitous Vedic verbal ritual formula (mantra) in Brahmanical traditions and the modern period of Hinduism. This essay traces the Gayatri’s changing theological backgrounds, ritual contexts and political uses in the modern period. It seeks to understand the history of the Gayatri’s transformations in modern India, and questions how the Gayatri transitioned from a private initiation ritual in Vedic Brahmanical culture to a popular public mantra. Hindu reform movements at the turn of the twentieth century provide important clues for how the mantra may have become more public, particularly through reconversion rituals (suddhis) to Hinduism regardless of gender, religion, or caste. Reconversion rituals contributed to removing the Gayatri from the jurisdiction of orthodox Brahmanical authorities, and transformed it from a central symbol of twice-born Vedic identity into a broader symbol of Hindu identity. In some cases, the Gayatri is now universalized as a secular mantra in India, though one that maintains tacit Hindu or Indian nationalist identities.
The Hagiographer and the Avatar: The Life and Works of Narayan Kasturi, by Antonio Rigopoulos
Authors: Rinehart Robin
Published: September 2023

The Hagiographer and the Avatar: The Life and Works of Narayan Kasturi, by Antonio Rigopoulos. Albany, NY: State University of New York Press, 2021. xxv + 499 pp., £75 (hb), £25 (pb). ISBN 978-1-4384-8229-3 (hb), 978-1-4384-8228-6 (pb).
A sorte de Azarias
Authors: Pires de Brito Regina , Concato Camila , Panhoca da Silva Pedro
Published: September 2023

Este artigo tem como objetivo ilustrar possibilidades de aprendizado em sala de aula da Educação Básica a partir da leitura e análise do conto “O dia em que explodiu Mabata-bata”, do escritor moçambicano Mia Couto. Para isso, serão elencadas questões culturais de Moçambique e abordagens míticas, temporais e de expressão animista. O tema relacionado à literatura dos países africanos de língua oficial portuguesa foi escolhido por ser parte do projeto de pesquisa Educação Básica e Estudos Lusófonos: A Prática da Literatura Africana de Língua Portuguesa no Ensino Médio (financiado pelo Fundo Mackpesquisa).
Results of a pilot clinical trial of the safety and efficacy of an original glycoprotein IIb/IIIa receptor inhibitor in acute coronary syndrome
Authors: Lukyanov S. V. , Glukhov Yu. F. , T. E. V. , Tankhilevich B. M. , Zateyshchikov D. A. , Khlevchuk T. V. , Bondareva I. B.
Published: September 2023

Aim. To study the safety and efficacy of Angipure in acute ST-segment elevation coronary syndrome (STE-ACS) and high-risk percutaneous transluminal coronary angioplasty (PTCA) compared with eptifibatide.

Material and methods. The study included 157 patients with STE-ACS. High-risk PTCA included massive or total coronary artery thrombosis, noreflow/slow-reflow phenomenon, and acute stent thrombosis. Fifty-five people received Angipure at a dose of 0,72 mg/kg, 52 — at a dose of 0,40 mg/kg, while 50 patients received eptifibatide (Integrilin). We conducted clinical and laboratory studies, electrocardiography (ECG), coronary angiography.

Results. According to the criteria "Frequency and severity of hemorrhagic events, including hemorrhagic stroke", "Frequency, severity of other adverse events", there were no differences in safety between Angipure at doses of 0,40 and 0,72 mg/kg and eptifibatide. Complaints, clinical symptoms, vital signs, complete blood count, biochemical and coagulation tests, ECG in patients of different groups were similar and had unidirectional dynamics. The use of Angipure or eptifibatide was considered effective if no adverse outcomes (death, recurrent acute ischemic event, need for urgent revascularization) were observed within 30 days. There were no lethal outcomes. One repeated acute ischemic event was registered in each group. In groups of patients receiving Angipure 0,40 mg/kg and eptifibatide, urgent revascularization was required once each.

Conclusion. Angipure and eptifibatide have similar safety and efficacy.
Identification of c.683_684insCTGCAAGGACAAATCTGACGA pathogenic variant of the low-density lipoprotein receptor gene in a patient with familial hypercholesterolemia: a case report
Authors: Korneva V. A. , Mandelshtam M. Yu. , Orlov A. V. , Vasiliev V. B. , Kuznetsova T. Yu. , Zakharova F. M.
Published: September 2023

Familial hypercholesterolemia (FH) is one of the most common monogenic diseases that leads to the early development of atherosclerosis and is characterized by a poor prognosis. However, only about 1% of FH cases are diagnosed in Russia. The aim of this study was to determine the genetic defect in the FH family and conduct DNA diagnostics in the proband relatives. The study was performed on blood samples obtained with the informed consent of the patients. Polymerase chain reaction and polyacrylamide gel electrophoresis were used. We report c.683_684insCTGCAAGGA CAAATCTGACGA pathogenic variant of the low-density lipoprotein receptor (LDLR) gene for the first time in Russia and demonstrate its cosegregation in a family with high blood cholesterol. The c.683_684in sCTGCAAGGACAAATCTGACGA insertion is considered as a probable cause of FH.
Expert opinion on "Results of a pilot clinical trial of the safety and efficacy of an original glycoprotein IIb/IIIa receptor inhibitor drug in acute coronary syndrome"
Authors: Martsevich S. Yu.
Published: September 2023

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Impact of the Vladivostok landfill on shaping the environmental risk of water resources pollution
Authors: Kurochkina Valentina , Volkova Vladislava
Published: September 2023

Many countries are implementing MSW recycling programmes to improve the environmental situation and quality of life. The sphere of solid municipal waste management in Russia lags behind the developed countries and is mainly aimed at landfilling. This is largely due to the problem of separate collection of MSW.
The article considers the problem of waste management on the example of Primorsky Krai and its regional centre Vladivostok, which is characterized by the problem of solid municipal and domestic waste disposal, which negatively affects the ecological situation of the whole region. The article analyzes the state of the environment of the city and its surrounding areas, identifying the main sources of pollution.
The data on waste recycling and population dynamics are analyzed, a map of Primorsky Krai landfills and a scheme of solid waste recycling are shown.
Measures aimed at enhancing the role of waste recycling as a promising method of waste management are proposed.
The role of multilateral cooperation in the transition to a circular economy and low-carbon development: waste recycling associations as agents of change
Authors: Avramenko Andrey , Beketova Anastasia
Published: September 2023

The article presents the results of a study of the activities and role of professional associations for recycling of production and consumption waste in connection with the start of Russia's transition to a circular economy and the implementation of the strategic federal project of the same name. A retrospective analysis of the development of the concept of “closed loop” over the past decades has been carried out in the context of the disposal of production and consumption waste and the formation of the concept of a circular economy. Specific institutional, cultural, and legal barriers are described that prevent the transition of the current economic system to sustainable cyclical patterns of production and consumption with the usage of secondary material resources in production. A classification of waste recycling associations is proposed based on information about the participants of associations and the functions they perform: associations of manufacturers and importers of goods and packaging within the framework of the implementation of extended producers’ responsibility standards, associations of waste recycling companies, associations of manufacturers and recycling companies, associations of complex partnerships. For each identified type of associations, a case example is described. Based on the analysis of the activities of foreign (USA, European Union (Netherlands), China, India) and national associations for waste management, as well as the International Solid Waste Association, which operates at the global level, via comparison of their organizational structure and legal framework, characteristic features for each type of associations are identified, as well as cooperative forms of interaction relevant for Russia. The key problems associated with the activities of waste recycling associations in Russia are described, as well as the prospects for the creation and transformation of such associations, taking into account the socio-economic development policy pursued in the country.
DESVENDANDO O AVESSO: A LEITURA LATERAL COMO FERRAMENTA PARA O LETRAMENTO DIGITAL EM SALA DE AULA
Authors: Coutinho Victor Araujo , Ribeiro Ormezinda Maria
Published: September 2023

O presente artigo nos convida a explorar o desenvolvimento do mundo da leitura sob a ótica do letramento digital no século XXI. Com o advento da internet e da disseminação de (falsas) informações em massa, se torna cada vez mais necessário o olhar acadêmico com foco no desenvolvimento do pensamento crítico dentro das salas de aula. Desse modo, tecemos nossas reflexões a fim de aproximar o conceito de leitura lateral, um método de leitura contextualizado para o momento em que vivemos, do currículo da Educação Básica brasileira. Para tanto, exploramos uma proposta de ensino feita para alunos do oitavo e nono ano do ensino fundamental de uma escola pública de João Pessoa (PB). Nosso objetivo é abrir um espaço de discussão para que professoras e professores analisem a teoria e a proposta de perto, de modo que encontrem meios de incorporar esta nova técnica de leitura em seu repertório pedagógico.
Losartan-Induced Angioedema with Acute Hypoxemic Respiratory Failure (Anaphylaxis): A Case Report
Authors: Kagzi Yusuf , Money David Bradley , Oxner Asa Zoe , Kagzi Alifiya
Published: September 2023

Angioedema is a condition characterized by swelling of the skin or mucosa resulting from loss of vascular integrity that leads to swelling of mucosal tissues and can lead to life-threatening respiratory compromise. Drug-induced angioedema is not a frequent side effect seen with angiotensin receptor blockers (ARBs), particularly when there are no other contributing risk factors like a prior episode. Few studies reported subsequent angioedema episodes after ARB use in patients who had a prior episode with angiotensin converting enzyme inhibitors; however, there are very few cases that documented non-fatal angioedema after ARB as the only therapy. We report a rare case of life-threatening anaphylaxis after losartan use. We hope that our case will bring awareness to this rare but fatal side effect in order to quickly recognize it and encourage further research.
Electrolyte Disorders in Mitochondrial Cytopathies: A Systematic Review
Authors: Viering Daan H.H.M. , Vermeltfoort Lars , Bindels René J.M. , Deinum Jaap , de Baaij Jeroen H.F.
Published: September 2023

Significance Statement

Several recent studies identified mitochondrial mutations in patients with Gitelman or Fanconi syndrome. Mitochondrial cytopathies are generally not considered in the diagnostic workup of patients with electrolyte disorders. In this systematic review, we investigated the presence of electrolyte disorders in patients with mitochondrial cytopathies to determine the relevance of mitochondrial mutation screening in this population. Our analysis demonstrates that electrolyte disorders are commonly reported in mitochondrial cytopathies, often as presenting symptoms. Consequently, more clinical attention should be raised for mitochondrial disease as cause for disturbances in electrolyte homeostasis. Further prospective cohort studies are required to determine the exact prevalence of electrolyte disorders in mitochondrial cytopathies.

Background

Electrolyte reabsorption in the kidney has a high energy demand. Proximal and distal tubular epithelial cells have a high mitochondrial density for energy release. Recently, electrolyte disorders have been reported as the primary presentation of some mitochondrial cytopathies. However, the prevalence and the pathophysiology of electrolyte disturbances in mitochondrial disease are unknown. Therefore, we systematically investigated electrolyte disorders in patients with mitochondrial cytopathies.

Methods

We searched PubMed, Embase, and Google Scholar for articles on genetically confirmed mitochondrial disease in patients for whom at least one electrolyte is reported. Patients with a known second genetic anomaly were excluded. We evaluated 214 case series and reports (362 patients) as well as nine observational studies. Joanna Briggs Institute criteria were used to evaluate the quality of included studies.

Results

Of 362 reported patients, 289 had an electrolyte disorder, with it being the presenting or main symptom in 38 patients. The average number of different electrolyte abnormalities per patient ranged from 2.4 to 1.0, depending on genotype. Patients with mitochondrial DNA structural variants seemed most affected. Reported pathophysiologic mechanisms included renal tubulopathies and hormonal, gastrointestinal, and iatrogenic causes.

Conclusions

Mitochondrial diseases should be considered in the evaluation of unexplained electrolyte disorders. Furthermore, clinicians should be aware of electrolyte abnormalities in patients with mitochondrial disease.
FinTech and Banks: Strategic Partnerships That Circumvent State Usury Laws
Authors: Elliehausen Gregory , Hannon Simona M.
Published: September 2023

Previous research has found evidence suggesting that financial technology (FinTech) lenders seek out opportunities in markets that have been underserved by mainstream banks. The research focuses primarily on the effect of bank market structure, limited income, and economic hardship in attracting FinTech companies to underserved markets. This paper expands the scope of FinTech research by investigating the role of interest rate regulation of consumer credit and institutional risk segmentation in FinTech lenders’ efforts to solicit new customers in the personal loan market. We find that strategic partnerships between FinTech companies and specialist banks target marginal-risk, near-prime, and low-prime consumers for credit card and other debt consolidation loans. These FinTech-bank partnerships especially target marginal consumers in states with low interest rate ceilings. Mainstream banks largely avoid higher-risk consumers, and low rate ceilings inhibit consumer finance company lending, which historically has been the major source of personal loans for higher risk consumers and may compete with banks at the margin. In partnering with the specialist banks, the FinTech lenders are able to take advantage of federal preemptions from state rate ceilings to lend profitably to higher-risk consumers in states with low rate ceilings to compete in these markets.
Effect of aerobic training on depression and thyroid function in treated hypothyroid women
Authors: Gayar Saher Lotfy El
Published: September 2023

INTRODUCTION: Hypothyroidism is commonly associated with depression and a slowing in mental activity. OBJECTIVES: The current investigation aimed to investigate the effect of aerobic training on depression and thyroid function in treated hypothyroid females. METHODS AND MATERIALS: Thirty women diagnosed with primary hypothyroidism that was regulated and accompanied by mild to moderate levels of depression completed a 12-week randomized controlled exercise trial involving two equal groups: aerobic (n = 15) and control (n = 15) groups. The exercising group performed three sessions of aerobic exercise per week at low to moderate intensity for 12 consecutive weeks while the control group performed no exercise intervention during the same duration. At baseline and post-intervention, Beck Depression Inventory score (BDIS), thyroid stimulating hormone (TSH) and free thyroxin (T4) were assessed. RESULTS: The exercising group showed significant improvements in BDIS, TSH and free T4 compared to baseline (p < 0.05) with negligible change in the control group (p > 0.05). As compared to the control, all measured items differed significantly in favor to the aerobic training group. CONCLUSION: In women with treated hypothyroidism, aerobic training can minimize depressive symptoms and enhance thyroid function.
Downregulation of SIRT1 and GADD45G genes and left atrial fibrosis induced by right ventricular dependent pacing in a complete atrioventricular block pig model
Authors: Lee Wei-Chieh , Lin Yu-Sheng , Chen Man-Jing , Ho Wan-Chun , Chen Huang-Chung , Chang Tzu-Hao , Liu Ping-Yen , Chen Mien-Cheng
Published: September 2023

The molecular and genetic mechanisms underlying left atrial (LA) enlargement and atrial fibrosis following right ventricular (RV) dependent pacing remain unclear. Our objective was to investigate genetic expressions in the LA of pigs subjected to RV pacing for atrioventricular block (AVB), as well as to identify the differential gene expressions affected by biventricular (BiV) pacing. We established an AVB pig model and divided the subjects into three groups: a sham control group, an RV pacing group, and a BiV pacing group. Differential expression genes (DEGs) analyses conducted through next-generation sequencing (NGS) and enrichment analyses were employed to identify genes with altered expression in the LA myocardium. The RV pacing group showed a significant increase in extracellular fibrosis in the LA myocardium compared to the control group. NGS analysis revealed suppressed expression of the sirtuin signaling pathway in the RV pacing group. Among the DEGs within this pathway, GADD45G was found to be downregulated in the RV pacing group and upregulated in the BiV pacing group. Remarkably, the BiV pacing group exhibited elevated levels of GADD45G protein. In our study, we observed significant downregulation of SIRT1 and GADD45G genes, which are associated with the sirtuin signaling pathway, in the LA myocardium of the RV pacing group when compared to the control group. Moreover, these genes, which were downregulated in the RV pacing group, displayed a noteworthy upregulation in the BiV pacing group when compared to the RV pacing group.
Computational design of novel nanobodies targeting the receptor binding domain of variants of concern of SARS-CoV-2 v1
Authors: Longsomboon Phoomintara
Published: September 2023

The COVID-19 pandemic has created an urgent need for effective therapeuticand diagnostic strategies to manage the disease caused by the severe acuterespiratory syndrome coronavirus 2 (SARS-CoV-2). However, the emergence ofnumerous variants of concern (VOCs) has made it challenging to develop targetedtherapies that are broadly specific in neutralizing the virus. In this study, weaimed to develop neutralizing nanobodies (Nbs) using computational techniquesthat can effectively neutralize the receptor-binding domain (RBD) of SARS-CoV-2VOCs. We evaluated the performance of different protein-protein dockingprograms and identified HDOCK as the most suitable program for Nb/RBD dockingwith high accuracy. Using this approach, we designed 14 novel Nbs with highbinding affinity to the VOC RBDs. The Nbs were engineered with mutated aminoacids that interacted with key amino acids of the RBDs, resulting in higherbinding affinity than human angiotensin-converting enzyme 2 (ACE2) and otherviral RBDs or hemagglutinins (HAs). The successful development of these Nbsdemonstrates the potential of molecular modeling as a low-cost andtime-efficient method for engineering effective Nbs against SARS-CoV-2. Theengineered Nbs have the potential to be employed in RBD-neutralizing assays,facilitating the identification of novel treatment, prevention, and diagnosticstrategies against SARS-CoV-2.
LOCUCIONES Y SUS VARIANTES EN EL DICCIONARIO DESCRIPTIVO DEL VALLE DE ABURRÁ
Authors: Ortiz Correa Adriana María
Published: September 2023

La variación es un fenómeno lingüístico propio de algunas locuciones registradas en el Diccionario Descriptivo del Valle de Aburrá (DEVA), que consiste en cualquier cambio o alteración de carácter morfológico, gramatical, sintáctico o léxico que se produzca en dichas unidades fraseológicas. El concepto de variación cuestiona el carácter fijo propio de las locuciones y plantea la discusión sobre la posibilidad constante de la creación por parte de los hablantes y la interpretación que ellos mismos hacen de sus significados en relación con los contextos discursivos de emisión.
ANÁLISIS LINGÜÍSTICO DE ARTÍCULOS DE INVESTIGACIÓN EN CIENCIAS SOCIALES Y HUMANAS
Authors: Sánchez Upegui Alexánder Arbey
Published: September 2023

Este estudio presenta una aproximación teórica al artículo científico, con el fin de precisar categorías conceptuales y proponer una perspectiva teórico-metodológica de análisis. Esto, con base en los conceptos de movidas y pasos retóricos. Durante la revisión no se encontró una correlación entre alfabetización académica y procesos editoriales de revistas científicas. Las principales conclusiones de esta revisión son: investigar, escribir y publicar forman una triada inherente al desarrollo intelectual y al avance académico-investigativo. La escritura investigativa presenta diversas dificultades; además, es una problemática soslayada. Las revistas científicas y los grupos de investigación, en cuanto que comunidades discursivas académico-investigativas, desarrollan estrategias para el fortalecimiento de competencias discursivas de carácter científico.
UNIDADES FRASEOLÓGICAS EN AIRE DE TANGO DE MANUEL MEJÍA VALLEJO
Authors: Villegas María Cristina
Published: September 2023

La novela Aire de tango, del escritor antioqueño Manuel Mejía Vallejo, es una fuente importante para el estudio del lenguaje antioqueño. En el discurso del narrador se encuentran dichos, refranes y otras unidades fraseológicas fijas propias de la cultura antioqueña de la época y muchas de ellas aún permanecen en el lenguaje cotidiano de la ciudad y de la región. En este trabajo se enfatizó en el estudio de las unidades fraseológicas fijas presentes en la obra, las cuales se cotejaron con tres diccionarios de fraseologismos, y a la vez se verificó su actualidad a través de una encuesta realizada a 50 personas de distintas edades.
Expanding the Boundaries of Digital Inclusion: Perspectives From Network Peripheries and Non‐Adopters
Authors: McMahon Rob , Nazarova Nadezda , Robinson Laura
Published: September 2023

In this thematic issue, we present research from authors who seek to contest, challenge, and reimagine what digital inclusion is and what it might be. Authors present work from understudied vantage points and “hard to reach” terrains, such as communities that remain geographically, technically, socially, economically, and metaphorically “disconnected”—sometimes by choice. Through their attention to the role of intangible factors like relationality, social capital, emotion, sovereignty, and liminality, the articles collectively push against and expand the boundaries of digital inclusion research and practice.
MORAL IMPERATIVES OF THE FORMATION OF THE MODERN UKRAINIAN POLITICAL NATION: TRUST AND HUMANITY
Authors:   Research Institute of Ukrainian Studies, Ministry of Education and Science of Ukraine (Kyiv) Ukraine, Krysachenko Valentyn
Published: September 2023

The moral factors of the formation of the modern Ukrainian political nation are investigated. State policy is determined by the national interests of the entire society, ensuring the rights and freedoms of citizens. For the formation of a consolidated political nation, the following are important: statehood, democratic system, common interests, preservation of historical memory, establishment of social harmony, tolerance and consensus. The traced foundation of Ukrainian national unity is trust and humanity in relations. In traditional culture, relations between people were based on the principles of trust, responsibility, obligation, respect, goodness and justice, collective concern for one’s neighbor, and devotion to the native land. Foreign insult imposed a foreign matrix of behavior in Ukraine, the canons of which were treason and service to the authorities, deception, hatred of others and contempt for the weak, which significantly affected the completeness and content of the moral imperatives of Ukrainianism. Particular attention is paid to the categories of trust and betrayal: the first appears to be a tiresome source of growth of the unity of the nation, the second is its destroyer and a means of increasing the resource potential of the aggressors. Emphasis is placed on the functions of the main forms of moral imperatives — value and consolidation: in the first case, we are talking about integrating ties within the ethnic group and its subsystems, in the second — the synergy of interpersonal positive relationships based on trust, understanding and mutual assistance between moral subjects.