bluuebunny/crossref_metadata_2025 huggingface dataset:
Beyond Global Charge: Role of Amine Bulkiness and Protein Fingerprint on Nanoparticle–Cell Interaction
Authors: Burnand David , Milosevic Ana , Balog Sandor , Spuch‐Calvar Miguel , Rothen‐Rutishauser Barbara , Dengjel Jörn , Kinnear Calum , Moore Thomas L. , Petri‐Fink Alke
Published: September 2018

Amino groups presented on the surface of nanoparticles are well‐known to be a predominant factor in the formation of the protein corona and subsequent cellular uptake. However, the molecular mechanism underpinning this relationship is poorly defined. This study investigates how amine type and density affect the protein corona and cellular association of gold nanoparticles with cells in vitro. Four specific poly(vinyl alcohol‐co‐N‐vinylamine) copolymers are synthesized containing primary, secondary, or tertiary amines. Particle cellular association (i.e., cellular uptake and surface adsorption), as well as protein corona composition, are then investigated. It is found that the protein corona (as a consequence of “amine bulkiness”) and amine density are both important in dictating cellular association. By evaluating the nanoparticle surface chemistry and the protein fingerprint, proteins that are significant in mediating particle–cell association are identified. In particular, primary amines, when exposed on the polymer side chain, are strongly correlated with the presence of alpha‐2‐HS‐glycoprotein, and promote nanoparticle cellular association.
Efficient Self‐Driven Photodetectors Featuring a Mixed‐Dimensional van der Waals Heterojunction Formed from a CdS Nanowire and a MoTe2 Flake
Authors: Lu Ming‐Yen , Chang Yung‐Ting , Chen Hsin‐Ju
Published: September 2018

Heterojunctions formed from low‐dimensional materials can result in photovoltaic and photodetection devices displaying exceptional physical properties and excellent performance. Herein, a mixed‐dimensional van der Waals (vdW) heterojunction comprising a 1D n‐type Ga‐doped CdS nanowire and a 2D p‐type MoTe2 flake is demonstrated; the corresponding photovoltaic device exhibits an outstanding conversion efficiency of 15.01% under illumination with white light at 650 µW cm−2. A potential difference of 80 meV measured, using Kelvin probe force microscopy, at the CdS–MoTe2 interface confirms the separation and accumulation of photoexcited carriers upon illumination. Moreover, the photodetection characteristics of the vdW heterojunction device at zero bias reveal a rapid response time (<50 ms) and a photoresponsivity that are linearly proportional to the power density of the light. Interestingly, the response of the vdW heterojunction device is negligible when illuminated at 580 nm; this exceptional behavior is presumably due to the rapid rate of recombination of the photoexcited carriers of MoTe2. Such mixed‐dimensional vdW heterojunctions appear to be novel design elements for efficient photovoltaic and self‐driven photodetection devices.
Atomic‐Scale Valence State Distribution inside Ultrafine CeO2 Nanocubes and Its Size Dependence
Authors: Hao Xiaodong , Yoko Akira , Chen Chunlin , Inoue Kazutoshi , Saito Mitsuhiro , Seong Gimyeong , Takami Seiichi , Adschiri Tadafumi , Ikuhara Yuichi
Published: September 2018

Atomic‐scale analysis of the cation valence state distribution will help to understand intrinsic features of oxygen vacancies (VO) inside metal oxide nanocrystals, which, however, remains a great challenge. In this work, the distribution of cerium valence states across the ultrafine CeO2 nanocubes (NCs) perpendicular to the {100} exposed facet is investigated layer‐by‐layer using state‐of‐the‐art scanning transmission electron microscopy‐electron energy loss spectroscopy. The effect of size on the distribution of Ce valence states inside CeO2 NCs is demonstrated as the size changed from 11.8 to 5.4 nm, showing that a large number of Ce3+ cations exist not only in the surface layers, but also in the center layers of smaller CeO2 NCs, which is in contrast to those in larger NCs. Combining with the atomic‐scale analysis of the local structure inside the CeO2 NCs and theoretical calculation on the VO forming energy, the mechanism of size effect on the Ce valence states distribution and lattice expansion are elaborated: nano‐size effect induces the overall lattice expansion as the size decreased to ≈5 nm; the expanded lattice facilitates the formation of VO due to the lower formation energy required for the smaller size, which, in principle, provides a fundamental understanding of the formation and distribution of Ce3+ inside ultrafine CeO2 NCs.
Detecting instrumental icing using automated double anemometry
Authors: Swytink‐Binnema Nigel , Godreau Charles , Arbez Cédric
Published: September 2018

In this paper, we propose several improvements to the standard double anemometry method for ice detection. In the double anemometry method, the wind speed measurement from a heated reference anemometer is compared with that of an unheated anemometer. A lower measurement from the unheated sensor suggests the presence of ice. First, we propose using a wind speed difference (not a ratio), because anemometers should not deviate significantly at any wind speed under ice‐free conditions. Second, the threshold should vary with ambient temperature to account for cup anemometer slowdown caused by thickening bearing grease. Finally, sensitive thresholds should be used to overdetect ice and false events removed during postprocessing. We created an algorithm to automatically determine the required thresholds and tested it on seven wind turbines during a full winter at a cold climate site. When compared with ice thickness measurements from cameras, the algorithm was equal to or outperformed the manual double anemometry method across all seven turbines.
Hecke relations in rational conformal field theory
Authors: Harvey Jeffrey A. , Wu Yuxiao
Published: September 2018

Abstract

We define Hecke operators on vector-valued modular forms of the type that appear as characters of rational conformal field theories (RCFTs). These operators extend the previously studied Galois symmetry of the modular representation and fusion algebra of RCFTs to a relation between RCFT characters. We apply our results to derive a number of relations between characters of known RCFTs with different central charges and also explore the relation between Hecke operators and RCFT characters as solutions to modular linear differential equations. We show that Hecke operators can be used to construct an infinite set of possible characters for RCFTs with two independent characters and increasing central charge. These characters have multiplicity one for the vacuum representation, positive integer coefficients in theirqexpansions, and are associated to a two-dimensional representation of the modular group which leads to non-negative integer fusion coefficients as determined by the Verlinde formula.
Mu-tau reflection symmetry with a high scale texture-zero
Authors: Nishi C. C. , Sánchez-Vega B. L. , Souza Silva G.
Published: September 2018

Abstract

The μτ -reflection symmetric neutrino mass matrix can accommodate all known neutrino mixing angles, with maximal atmospheric angle fixed, and predicts all the unknown CP phases of the lepton sector but is unable to predict the absolute neutrino mass scale. Here we present a highly predictive scenario where μτ -reflection is combined with a discrete abelian symmetry to enforce a texture-zero in the mass matrix of the heavy right-handed neutrinos that generate the light neutrino masses. Such a restriction reduces the free parameters of the low energy theory to zero and the absolute neutrino mass scale is restricted to few discrete regions, three in the few meV range and one extending up to around 30 meV. The heavy neutrino sector is dependent only on two free parameters which are further restricted to small regions from the requirement of successful leptogenesis. Mass degenerate heavy neutrinos are possible in one case but there is no resonant enhancement of the CP asymmetry.
Towards holography for quantum mechanics
Authors: Janik Romuald A.
Published: September 2018

Abstract

We derive a holographic description of the simplest quantum mechanical system, a 1d free particle. The dual formulation uses a couple of two-dimensional topological abelian BF theories with appropriate boundary conditions, interactions and constraints. The aim of this construction is not to use holography as a tool for quantum mechanics but rather to find the simplest possible setup in order to explore holography.
Controlled flavor violation in the MSSM from a unified Δ(27) flavor symmetry
Authors: de Medeiros Varzielas Ivo , López-Ibáñez M. L. , Melis Aurora , Vives Oscar
Published: September 2018

Abstract

We study the phenomenology of a unified supersymmetric theory with a flavor symmetry Δ(27). The model accommodates quark and lepton masses, mixing angles and CP phases. In this model, the Dirac and Majorana mass matrices have a unified texture zero structure in the (1, 1) entry that leads to the Gatto-Sartori-Tonin relation between the Cabibbo angle and ratios of the masses in the quark sectors, and to a natural departure from zero of the θ
13

ℓ

angle in the lepton sector. We derive the flavor structures of the trilinears and soft mass matrices, and show their general non-universality. This causes large flavor violating effects. As a consequence, the parameter space for this model is constrained, allowing it to be (dis)proven by flavor violation searches in the next decade. Although the results are model specific, we compare them to previous studies to show similar flavor effects (and associated constraints) are expected in general in supersymmetric flavor models, and may be used to distinguish them.
Physical models and embodied cognition
Authors: Stegmann Ulrich E.
Published: September 2018

Philosophers have recently paid more attention to the physical aspects of scientific models. The attention is motivated by the prospect that a model’s physical features strongly affect its use and that this suggests re-thinking modelling in terms of extended or distributed cognition. This paper investigates two ways in which physical features of scientific models affect their use and it asks whether modelling is an instance of extended cognition. I approach these topics with a historical case study, in which scientists kept records not only of their findings, but also of some the mental operations that generated the findings. The case study shows how scientists can employ a physical model (in this case diagrams on paper) as an external information store, which allows alternating between mental manipulations, recording the outcome externally, and then feeding the outcome back into subsequent mental manipulations. The case study also demonstrates that a models’ physical nature allows replacing explicit reasoning with visuospatial manipulations. I argue, furthermore, that physical modelling does not need to exemplify a strong kind of extended cognition, the sort for which external features are mereological parts of cognition. It can exemplify a weaker kind, instead.
Correction to: Sedimentary and geochemical characteristics of two small permafrost-dominated Arctic river deltas in northern Alaska
Authors: Fuchs Matthias , Grosse Guido , Jones Benjamin M. , Strauss Jens , Baughman Carson A. , Walker Donald A.
Published: September 2018

The original article can be found online.
The Existential Crisis of Citizenship of the European Union:The Argument for an Autonomous Status
Authors: GARNER Oliver
Published: September 2018

This article argues for the (re)construction of citizenship of the European Union as an autonomous status. As opposed to the current legal regime, whereby individuals with nationality of a Member State are automatically granted citizenship of the Union, under this proposal individuals would be free to choose whether or not to adopt the status of citizen of an incipient European polity. At present, thetelosand essence of citizenship of the Union is contested. It may be argued that the status is partial or incomplete. This has informed competing normative perspectives. ‘Maximalist’ positions praise the judicial construction of Union citizenship as destined to be the ‘fundamental status’ for all Member State nationals. By contrast, ‘minimalist’ positions argue that the status should remain ‘additional to’ Member State nationality, and the rights created therein should remain supplementary to the status and rights derived from national citizenship. This article will argue for a new approach to the dilemma. By emancipating the condition for acquisition of EU citizenship from nationality of a Member State, and reconstructing it as an autonomous choice for individuals, it is tentatively suggested that a new constitutional settlement for Europe may be generated.
Increasing research mentor training among biomedical researchers at Clinical and Translational Science Award hubs: The impact of the facilitator training initiative
Authors: Rogers Jenna , Sorkness Christine A. , Spencer Kimberly , Pfund Christine
Published: September 2018

As part of their mission, Clinical and Translational Science Award (CTSA) hubs are charged with developing, testing, and disseminating evidence-based practices to other CTSA hubs. Over the past 7 years, the University of Wisconsin-Madison has answered this charge by implementing the facilitator training (FT) initiative for research mentors. Three elements to advance training across the CTSA hubs have been critical: (1) using an FT model to empower others to build research mentor training at their local institutions; (2) tracking implementation of training events across the CTSA hubs over time; and (3) partnering with implementation sites to build local capacity and evaluate the effectiveness and quality of training. Here we report that facilitators have been trained at 75% of CTSA hubs. These facilitators report high satisfaction with the training and increased confidence in their ability to implement mentor training, and plan to implement local mentor training. These findings demonstrate that the FT initiative can serve as a model for dissemination and implementation of other workforce development interventions across the CTSA hubs.
From insertion to removal: A multicenter survival analysis of an admitted cohort with peripheral intravenous catheters inserted in the emergency department
Authors: Carr Peter J. , Rippey James C.R. , Cooke Marie L. , Higgins Niall S. , Trevenen Michelle , Foale Aileen , Rickard Claire M.
Published: September 2018

Background

Most patients admitted to the hospital via the emergency department (ED) do so with a peripheral intravenous catheter/cannula (PIVC). Many PIVCs develop postinsertion failure (PIF).

Objective

To determine the independent factors predicting PIF after PIVC insertion in the ED.

Methods

We analyzed data from a prospective clinical cohort study of ED-inserted PIVCs admitted to the hospital wards. Independent predictors of PIF were identified using Cox proportional hazards regression modeling.

Results

In 391 patients admitted from 2 EDs, the rate of PIF was 31% (n=118). The types of PIF identified were infiltration, occlusion, pain and/or peripheral intravenous assessment score >2 (ie, the hospital’s assessment of PIVC phlebitis), and dislodgement (ie, accidental securement device failure or purposeful removal). Of the PIVCs that failed, infiltration and occlusion combined were the most common causes of PIF (n=55, 47%). The median PIVC dwell time was 28.5 hours (interquartile range [IQR], 17.4–50.8 hours). The following variables were associated with increased risk of PIF: being an older patient (for a 1-year increase, hazard ratio [HR], 1.02; 95% confidence interval [CI], 1.01–1.03;P=.0001); having an Australian Triage Scale score of 1 or 2 compared to a score of 3, 4, or 5 (HR, 2.04; 95% CI, 1.39–3.01;P=.0003); having an ultrasound-guided PIVC (HR, 6.52; 95% CI, 2.11–20.1;P=.0011); having the PIVC inserted by a medical student (P=.0095); infection prevention breaches at insertion (P=.0326); and PIVC inserted in the ante cubital fossa or the back of hand compared to the upper arm (P=.0337).

Conclusion

PIF remains at an unacceptable level in both traditionally inserted and ultrasound-inserted PIVCs.

Clinical trial registration

Australian and New Zealand Trials Registry (ANZCTRN12615000588594).
Commentary on ‘Opportunities and Challenges of Engaged Indigenous Scholarship’ (Van de Ven, Meyer, & Jing, 2018)
Authors: Tsui Anne S.
Published: September 2018

The mission ofManagement and Organization Review, founded in 2005, is to publish research about Chinese management and organizations, foreign organizations operating in China, or Chinese firms operating globally. The aspiration is to develop knowledge that is unique to China as well as universal knowledge that may transcend China. Articulated in the first editorial published in the inaugural issue of MOR (2005) and further elaborated in a second editorial (Tsui, 2006), the question of contextualization is framed, discussing the role of context in the choices of the research question, theory, measurement, and research design. The idea of ‘engaged indigenous research’ by Van de Ven, Meyer, and Jing (2018) describes the highest level of contextualization, with the local context serving as the primary factor guiding all the decisions of a research project. Tsui (2007: 1353) refers to it as ‘deep contextualization’.
Response to Perkins and Murmann: Pay Attention to What Is and Isn't Unique about Tesla
Authors: MacDuffie John Paul
Published: September 2018

Perkins and Murmann (2018) advance a provocative thesis, based on Tesla Motors, that ‘a well-funded company could develop a new electric vehicle (EV) from scratch and move it into production within 3 to 5 years. . . .’ This thesis of feasibility – indeed likelihood – of more new entrant EV automakers is at odds with my recent work (e.g., Jacobides, MacDuffie, & Tae, 2016; MacDuffie, 2013) which argues that automotive OEMs have been able to prevent extensive value migration to suppliers and new entrants due to their structural role as system integrators with the capabilities to manage a primarily integral product and organizational architecture. This role is bolstered by societal demands for OEMs to meet regulatory requirements for safety and handle legal liability claims. These structural features have helped automotive OEMs avoid the fate of IBM, which saw massive value migration, after introducing the modular PC, to Intel and Microsoft (suppliers of key components). These same features, I argue, will position these OEMs for continued centrality, forestalling a wave of successful new entrants despite many new, disruptive changes in technology and business models.
Tesla and the Reshaping of the Auto Industry
Authors: Teece David J.
Published: September 2018

I've been asked to comment on this collection of three papers, each of which offers deep insights into the forces affecting the auto industry, particularly as concerns the relative positions of incumbent auto firms with respect to new electric vehicle entrants. Taken as a whole, the papers open a lens on the changes roiling the automotive sector. In this essay, I'll attempt to widen the aperture and provide a framework for a more systemic analysis of the forces reshaping the industry and the prospects for new entrants.
Voter uncertainty, political institutions, and legislative turnover
Authors: Krupnikov Yanna , Shipan Charles R.
Published: September 2018

The level of legislative turnover in a polity can have significant political consequences. Low turnover may increase the number of legislators who are out of touch with constituents, while high turnover can limit a legislature’s ability to fulfill its duties. Focusing on separation of powers arrangements, a factor overlooked by previous studies, we identify institutional conditions that affect turnover. When the executive and legislature are equally responsible for budgetary outcomes, we argue, this creates ambiguous contexts, leaving voters more likely to re-elect incumbents, thereby lowering turnover. We test our predictions using US state-level data.
Late Glacial Atmospheric Radiocarbon Variations Recorded in Scots Pine (Pinus sylvestris L.) Wood from KwiatkÓw, Central Poland
Authors: Krąpiec Marek , Michczyńska Danuta J , Michczyński Adam , Piotrowska Natalia , Goslar Tomasz , Szychowska-Krąpiec Elżbieta
Published: September 2018

Our project aimed to construct a Scots Pine (Pinus sylvestris L.) chronology for part of the Late Glacial and reconstruct changes in the 14C concentrations during this period. Kwiatków (Kolska Basin, central Poland) proved to be very prospective site, in which wood from the end of Allerød was recognized. A level of organic deposits with so-called fossil forest was encountered within the late-Vistulian terrace of the low valley of the Warta river. Dendrochronological analysis of over 267 samples complying to the requirements of the method allowed, at the present stage of the research, to construct a chronology spanning 265 yr. Fifty-two samples (5 consecutive rings each) were subjected to α-cellulose extraction and 14C measurements. Ninety-six results and the wiggle-matching technique anchor the chronology to the period 13,821–13,561 cal BP (Acomb=141.6%) according to the D_Sequence procedure and the IntCal13 calibration curve or to 13,800–13,540 cal BP according to the wiggle-matching technique using the χ2 test and raw data, i.e. the Heidelberg tree-ring sequence.
Primaries and Candidate Polarization: Behavioral Theory and Experimental Evidence
Authors: WOON JONATHAN
Published: September 2018

Do primary elections cause candidates to take extreme, polarized positions? Standard equilibrium analysis predicts full convergence to the median voter’s position with complete information, but behavioral game theory predicts divergence when players are policy-motivated and have out-of-equilibrium beliefs. Theoretically, I show that primary elections can cause greater extremism or moderation, depending on the beliefs candidates and voters have about their opponents. In a controlled incentivized experiment, I find that candidates diverge substantially and that primaries have little effect on average positions. Voters employ a strategy that weeds out candidates who are either too moderate or too extreme, which enhances ideological purity without increasing divergence. The analysis highlights the importance of behavioral assumptions in understanding the effects of electoral institutions.
The protein-sparing effect of α-lipoic acid in juvenile grass carp, Ctenopharyngodon idellus: effects on lipolysis, fatty acid β-oxidation and protein synthesis
Authors: Shi Xiao-chen , Jin Ai , Sun Jian , Tian Jing-jing , Ji Hong , Chen Li-qiao , Du Zhen-yu
Published: September 2018

To investigate the protein-sparing effect of α-lipoic acid (LA), experimental fish (initial body weight: 18·99 (sd 1·82) g) were fed on a 0, 600 or 1200 mg/kg α-LA diet for 56 d, and hepatocytes were treated with 20 μm compound C, the inhibitor of AMP kinase α (AMPKα), treated for 30 min before α-LA treatment for 24 h. LA significantly decreased lipid content of the whole body and other tissues (P<0·05), and it also promoted protein deposition in vivo (P<0·05). Further, dietary LA significantly decreased the TAG content of serum and increased the NEFA content of serum (P<0·05); however, there were no significant differences among all groups in the hepatopancreas and muscle (P>0·05). Consistent with results from the experiment in vitro, LA activated phosphorylation of AMPKα and notably increased the protein content of adipose TAG lipase in intraperitoneal fat, hepatopancreas and muscle in vivo (P<0·05). Meanwhile, LA significantly up-regulated the mRNA expression of genes involved in fatty acid β-oxidation in the same three areas, and LA also obviously down-regulated the mRNA expression of genes involved in amino acid catabolism in muscle (P<0·05). Besides, it was observed that LA significantly activated the mammalian target of rapamycin (mTOR) pathway in muscle of experimental fish (P<0·05). LA could promote lipolysis and fatty acid β-oxidation via increasing energy supply from lipid catabolism, and then, it could economise on the protein from energy production to increase protein deposition in grass carp. Besides, LA might directly promote protein synthesis through activating the mTOR pathway.
‘What Is It Like To …?’
Authors: GOLDSTICK D.
Published: September 2018

Philosophers speak of ‘what it’s like to’ have an experience without taking account of how semantically various the phrase is. ‘Blindsight’ visual perception lacks detail.
Response of canopy structure, light interception and grain yield to plant density in maize
Authors: Li J. , Xie R. Z. , Wang K. R. , Hou P. , Ming B. , Zhang G. Q. , Liu G. Z. , Wu M. , Yang Z. S. , Li S. K.
Published: September 2018

Good canopy structure is essential for optimal maize (Zea maysL.) production. However, creating appropriate maize canopy structure can be difficult, because the characteristics of individual plants are altered by changes in plant age, density and interactions with neighbouring plants. The objective of the current study was to find a reliable method for building good maize canopy structure by analysing changes in canopy structure, light distribution and grain yield (GY). A modern maize cultivar (ZhengDan958) was planted at 12 densities ranging from 1.5 to 18 plants/m2at two field locations in Xinjiang, China. At the silking stage (R1), plant and ear height increased with plant density as well as leaf area index (LAI), whereas leaf area per plant decreased logarithmically. The fraction of light intercepted by the plant (F) increased with increasing plant density, but the light extinction coefficient (K) decreased linearly from 0.61 to 0.39. Taking the optimum value ofF(95%) as an example, and using measured values ofKfor each plant density at R1 and the equation from Beer's law, the corresponding (theoretical) LAI for each plant density was calculated and optimum plant density (9.72 plants/m2) obtained by calculating the difference between theoretical LAIs and actual observations. Further analysis showed that plant density ranging from 10.64 to 11.55 plants/m2yielded a stable GY range. Therefore, taking into account the persistence time for maximum LAI, the plant density required to obtain an ideal GY maize canopy structure should be increased by 10–18% from 9.72 plants/m2.
The Preliminaries of the Fourth Lateran Council (1215): From an Orthodox Perspective
Authors: ANGOLD MICHAEL
Published: September 2018

The reaction of the Orthodox Church to the Fourth Lateran Council (1215) arguably set a pattern that would persist until the end of Byzantium. While members of the hierarchy were mostly opposed to accepting invitations to attend the council, the Emperor TheodoreiLaskaris saw it as an opportunity to open up a dialogue with the papacy in the hope of deriving some political advantage. This episode reveals that negotiations over the Union of Churches divided Byzantine society in a way that had not happened before 1204.
How Does Illiquidity Affect Delegated Portfolio Choice?
Authors: Dai Min , Goncalves-Pinto Luis , Xu Jing
Published: September 2018

In response to how they are compensated, mutual fund managers who are underperforming by mid-year are likely to increase the risk of their portfolios toward the year-end. We argue that an increase in the liquidity of the stocks that managers use to shift risk can lead to an increase in the size of their risky bets. This in turn hurts fund investors by increasing the costs of misaligned incentives associated with delegated portfolio management. We provide both theoretical and empirical results that are consistent with this argument. We use decimalization as an exogenous shock to liquidity to identify causal effects.
At-the-Market Offerings
Authors: Billett Matthew T. , Floros Ioannis V. , Garfinkel Jon A.
Published: September 2018

We study at-the-market (ATM) equity offerings, which are direct share issuances sold in the secondary market that forgo underwriters and “dribble-out” shares over time rather than raising them all at once. Enabled in 2008, their use has increased dramatically, and in 2016, their incidence and total proceeds were, respectively, 63% and 26% of those for seasoned equity offerings (SEOs). Determinants of firms’ choice between ATMs and SEOs are consistent with the costly certification hypothesis of Chemmanur and Fulghieri (1994). We also find that 65% of ATM proceeds are used to stockpile cash compared to 84% of SEO proceeds.
Survival and growth of tuataraSphenodon punctatusfollowing translocation from the Cook Strait to warmer locations in their historic range
Authors: Price Stephanie J. , Grayson Kristine L. , Gartrell Brett D. , Nelson Nicola J.
Published: September 2018

Post-translocation monitoring is fundamental for assessing translocation success and identifying potential threats. We measured outcomes for four cohorts of tuataraSphenodon punctatustranslocated to warmer climates outside of their ecological region, to understand effects of climate warming. Translocation sites were on average 2–4 °C warmer than the source site. We used three short-term measures of success: survival, growth and reproduction. Data on recaptures, morphometric measurements, and reproduction were gathered over 2.5 years following release. Although decades of monitoring will be required to determine long-term translocation success in this species, we provide an interim measure of population progress and translocation site suitability. We found favourable recapture numbers, growth of founders and evidence of reproduction at most sites, with greater increases in body mass observed at warmer, less densely populated sites. Variable growth in the adult population at one translocation site suggested that higher population density, intraspecific competition, and lower water availability could be responsible for substantial weight loss in multiple individuals, and we make management recommendations to reduce population density. Overall, we found that sites with warmer climates and lower population densities were potentially beneficial to translocated tuatara, probably because of enhanced temperature-dependent and density-dependent growth rates. We conclude that tuatara could benefit from translocations to warmer sites in the short term, but further monitoring of this long-lived species is required to determine longer-term population viability following translocation. Future vulnerability to rising air temperatures, associated water availability, and community and ecosystem changes beyond the scope of this study must be considered.
Detecting tropical wildlife declines through camera-trap monitoring: an evaluation of the Tropical Ecology Assessment and Monitoring protocol
Authors: Beaudrot Lydia , Ahumada Jorge , O'Brien Timothy G. , Jansen Patrick A.
Published: September 2018

Identifying optimal sampling designs for detecting population-level declines is critical for optimizing expenditures by research and monitoring programmes. The Tropical Ecology Assessment and Monitoring (TEAM) network is the most extensive tropical camera-trap monitoring programme, but the effectiveness of its sampling protocol has not been rigorously assessed. Here, we assess the power and sensitivity of the programme's camera-trap monitoring protocol for detecting occupancy changes in unmarked populations using the freely available application PowerSensor!. We found that the protocol is well suited to detect moderate (≥ 5%) population changes within 3–4 years for relatively common species that have medium to high detection probabilities (i.e. p > 0.2). The TEAM protocol cannot, however, detect typical changes in rare and evasive species, a category into which many tropical species and many species of conservation concern fall. Additional research is needed to build occupancy models for detecting change in rare and elusive species when individuals are unmarked.
Evolution in the structure of akaganeite and hematite during hydrothermal growth: anin situsynchrotron X-ray diffraction analysis
Authors: Peterson Kristina M. , Heaney Peter J. , Post Jeffrey E.
Published: September 2018

Synchrotron X-ray diffraction was used to monitor the hydrothermal precipitation of akaganeite (β-FeOOH) and its transformation to hematite (Fe2O3)in situ. Akaganeite was the first phase to form and hematite was the final phase in our experiments with temperatures between 150 and 200 °C. Akaganeite was the only phase that formed at 100 °C. Rietveld analyses revealed that the akaganeite unit-cell volume contracted until the onset of dissolution, and subsequently expanded. This reversal at the onset of dissolution was associated with a substantial and rapid increase in occupancy of the Cl site, perhaps by OH−or Fe3+. Rietveld analyses supported the incipient formation of an OH-rich, Fe-deficient hematite phase in experiments between 150 and 200 °C. The inferred H concentrations of the first crystals were consistent with “hydrohematite.” With continued crystal growth, the Fe occupancies increased. Contraction in botha-andc-axes signaled the loss of hydroxyl groups and formation of a nearly stoichiometric hematite.
Mechanisation in the Periphery: The Experience of Chilean Agriculture, c. 1850–90
Authors: ROBLES-ORTIZ CLAUDIO
Published: September 2018

This article examines mechanisation during the period of export-led growth in Chilean agriculture, c. 1850–90. According to conventional wisdom, since labour was cheap, landowners did not modernise theirhaciendas. The introduction of machinery was late and superficial; the large estate remained backward and inefficient. This view is flawed by lack of quantitative evidence and a narrow approach. Using imports and stocks data, and case material from the National Agricultural Society's bulletin, the article presents an alternative interpretation. The development of the market for agricultural equipment involved a fruitful exchange of technical expertise between the foreign importing companies and local landowners and experts. Mechanisation solved labour supply bottlenecks, and developed primarily on harvest tasks, above all the threshing of wheat. The scale and pattern of mechanisation were consistent with the development of this process in other countries’ older agricultures. The area mechanically harvested was much larger than previously estimated. Mechanisation was a significant transformation in the agricultural sector.
Travel, Modernity and Rural Landscapes in Nineteenth-Century Liguria
Authors: PIANA PIETRO , WATKINS CHARLES , BALZARETTI ROSS
Published: September 2018

New roads and, later, railways were essential for the modernisation and rapid economic development of north-western Italy in the early nineteenth century. The new routes also encouraged an increasing number of foreign travellers to visit the region. They opened up fresh tracts of countryside and provided novel viewpoints and points of interest; many travellers took the opportunity to record these views with topographical drawings and watercolours. In this article we make use of some of these views to examine how the modernised transport routes released new places to be celebrated by tourists and became themselves features and objects of especial interest and comment. We examine the works of three artists, one English and two Italian, who depicted landscapes of contrasting rural Ligurian landscapes. Their drawings and prints are contextualised and interpreted with maps, field data, archival documents and contemporary descriptions of roads and railways by travellers and in guidebooks.
A homotopy-theoretic model of function extensionality in the effective topos
Authors: FRUMIN DAN , VAN DEN BERG BENNO
Published: September 2018

We present a way of constructing a Quillen model structure on a full subcategory of an elementary topos, starting with an interval object with connections and a certain dominance. The advantage of this method is that it does not require the underlying topos to be cocomplete. The resulting model category structure gives rise to a model of homotopy type theory with identity types, Σ- and Π-types, and functional extensionality. We apply the method to the effective topos with the interval object ∇2. In the resulting model structure we identify uniform inhabited objects as contractible objects, and show that discrete objects are fibrant. Moreover, we show that the unit of the discrete reflection is a homotopy equivalence and the homotopy category of fibrant assemblies is equivalent to the category of modest sets. We compare our work with the path object category construction on the effective topos by Jaap van Oosten.
The New Ethics of Neuroethics
Authors: BULLER TOM
Published: September 2018

According to a familiar distinction, neuroethics incorporates the neuroscience of ethics and the ethics of neuroscience. Within neuroethics, these two parts have provoked distinct and separate lines of inquiry, and there has been little discussion of how the two parts overlap. In the present article, I try to draw a connection between these two parts by considering the implications that are raised for ethics by scientific findings about the way we make moral decisions. The main argument of the article is that although neuroscience is “stretching” ethics by revealing the empirical basis of our moral decisions and, thereby, challenging our present understanding of the dominant ethical theories, substantial further questions remain regarding the impact that neuroscience will have on ethics more broadly.
Neurolaw and Neuroethics
Authors: CHANDLER JENNIFER A.
Published: September 2018

This short article proposes a conceptual structure for “neurolaw,” modeled loosely on the bipartite division of the sister field of neuroethics by Adina Roskies into the “ethics of neuroscience” and the “neuroscience of ethics.” As normative fields addressing the implications of scientific discoveries and expanding technological capacities affecting the brain, “neurolaw” and neuroethics have followed parallel paths. Similar foundational questions arise for both about the validity and utility of recognizing them as distinct subfields of law and ethics, respectively. In both, a useful distinction can be drawn between a self-reflexive inquiry (the neuroscience of ethics and law) and an inquiry into the development and use of brain science and technologies (the ethics and law of neuroscience). In both fields, these two forms of inquiry interact in interesting ways. In addition to a proposed conceptual structure for neurolaw, the article also addresses the neurolegal versions of the critiques made against neuroethics, including charges of reductionism, fact/value confusion, and biological essentialism.
Brain–Computer Interfaces: Lessons to Be Learned from the Ethics of Algorithms
Authors: WOLKENSTEIN ANDREAS , JOX RALF J. , FRIEDRICH ORSOLYA
Published: September 2018

Brain–computer interfaces (BCIs) are driven essentially by algorithms; however, the ethical role of such algorithms has so far been neglected in the ethical assessment of BCIs. The goal of this article is therefore twofold: First, it aims to offer insights into whether (and how) the problems related to the ethics of BCIs (e.g., responsibility) can be better grasped with the help of already existing work on the ethics of algorithms. As a second goal, the article explores what kinds of solutions are available in that body of scholarship, and how these solutions relate to some of the ethical questions around BCIs. In short, the article asks what lessons can be learned about the ethics of BCIs from looking at the ethics of algorithms. To achieve these goals, the article proceeds as follows. First, a brief introduction into the algorithmic background of BCIs is given. Second, the debate about epistemic concerns and the ethics of algorithms is sketched. Finally, this debate is transferred to the ethics of BCIs.
Ethical Considerations in Ending Exploratory Brain–Computer Interface Research Studies in Locked-in Syndrome
Authors: KLEIN ERAN , PETERS BETTS , HIGGER MATT
Published: September 2018

Brain–computer interface (BCI) is a promising technology for restoring communication in individuals with locked-in syndrome (LIS). BCI technology offers a potential tool for individuals with impaired or absent means of effective communication to use brain activity to control an output device such as a computer keyboard. Exploratory studies of BCI devices for communication in people with LIS are underway. Research with individuals with LIS presents not only technological challenges, but ethical challenges as well. Whereas recent attention has been focused on ethical issues that arise at the initiation of studies, such as how to obtain valid consent, relatively little attention has been given to issues at the conclusion of studies. BCI research in LIS highlights one such challenge: How to decide when an exploratory BCI research study should end. In this article, we present the case of an individual with presumed LIS enrolled in an exploratory BCI study. We consider whether two common ethical frameworks for stopping randomized clinical trials—equipoise and nonexploitation—can be usefully applied to elucidating researcher obligations to end exploratory BCI research. We argue that neither framework is a good fit for exploratory BCI research. Instead, we apply recent work on clinician-researcher fiduciary obligations and in turn offer some preliminary recommendations for BCI researchers on how to end exploratory BCI studies.
Therapy for fatigue and cognitive dysfunction in postural orthostatic tachycardia syndrome
Authors: Boris Jeffrey R. , Bernadzikowski Thomas
Published: September 2018

Introduction

Severe fatigue and cognitive dysfunction are frequent symptoms in patients with postural orthostatic tachycardia syndrome. They can be debilitating, and often do not resolve despite improvement in haemodynamic symptoms. Our analysis was intended to assess clinical outcomes of medication treatment for these symptoms in a large, single-centre paediatric programme.

Materials and Methods

We performed a retrospective review of patients treated for fatigue and cognitive dysfunction. Patients aged 18 years or younger at the time of initial diagnosis were included. Patients who had a specific medication ordered five or more times for these symptoms were confirmed by chart review for clinical improvement. Percentage of patients with clinical improvement for each medication and overall for all medications, as well as the number of medications per patient required to achieve improvement, were assessed. Data were analysed based on gender as well. t-Test and χ2analyses were used to assess for differences between means in variables, or specific variables.

Results

A total of 708 patients met study criteria, of whom 517 were treated for fatigue or brain fog. Overall efficacy was 68.8%, with individual medication effectiveness ranging from 53.1 (methylphenidate) to 16.5% (atomoxetine). There was no significant difference in efficacy with respect to gender. The median number of medications used per patient was 2, without gender difference. Therapy was limited by side effects or lack of efficacy.

Discussion

Medications are effective in the improvement of fatigue and cognitive dysfunction in these patients. However, trials of multiple medications may be needed before achieving clinical improvement.
Dysphagia characteristics in Huntington’s disease patients: insights from the Fiberoptic Endoscopic Evaluation of Swallowing and the Swallowing Disturbances Questionnaire
Authors: Manor Yael , Oestreicher-Kedem Yael , Gad Alona , Zitser Jennifer , Faust-Socher Achinoam , Shpunt Dina , Naor Stav , Inbar Noit , Kestenbaum Meir , Giladi Nir , Gurevich Tanya
Published: September 2018

Background

Huntington’s disease (HD) is a neurodegenerative disease characterized by increasing dysphagia as the disease progresses. Specific characteristics of the HD dysphagia are not well defined.

Objective

To characterize the swallowing disturbances of HD patients, to evaluate the feasibility of Fiberoptic Endoscopic Evaluation of Swallowing (FEES) in assessing dysphagia in HD patients, and to discern the relation between FEES findings and patients’ self-report on dysphagia symptoms and swallowing related quality of life (SWAL-QOL).

Method

A retrospective case series in a tertiary referral center. All recruited HD patients underwent Bed Side Swallowing Evaluation (BSE), FEES, the Unified Huntington’s Disease Rating Scale (UHDRS), and the Montreal Cognitive Assessment (MoCA). All completed the Swallowing Disturbances Questionnaire (SDQ) and the SWAL-QOL questionnaire.

Results

Fourteen HD patients were recruited. All were able to complete the FEES study. The FEES demonstrated delayed swallowing reflex, solid food residues, and pre/post swallowing spillage in most patients (50%, 53.5%, 83.3%, and 87.5%, respectively). The mean SDQ score was 13.2. Significant correlations were found between the SWAL-QOL fear of eating score; the SDQ oral, pharyngeal, and total scores; and the FEES parameters of pureed and solid food bolus flow time. Significant correlations were also found between the total UHDRS score, the volitional cough score, and the SWAL-QOL disease burden score.

Conclusion

HD patients exhibit prominent unique oropharyngeal dysphagia features that may serve as a marker of disease progression. The FEES and the SDQ are valuable tools for detecting these features in HD patients with swallowing disturbance.
Decoding Brain States for Planning Functional Grasps of Tools: A Functional Magnetic Resonance Imaging Multivoxel Pattern Analysis Study
Authors: Buchwald Mikolaj , Przybylski Łukasz , Króliczak Gregory
Published: September 2018

Objectives: We used multivoxel pattern analysis (MVPA) to investigate neural selectivity for grasp planning within the left-lateralized temporo-parieto-frontal network of areas (praxis representation network, PRN) typically associated with tool-related actions, as studied with traditional neuroimaging contrasts. Methods: We used data from 20 participants whose task was to plan functional grasps of tools, with either right or left hands. Region of interest and whole-brain searchlight analyses were performed to show task-related neural patterns. Results: MVPA revealed significant contributions to functional grasp planning from the anterior intraparietal sulcus (aIPS) and its immediate vicinities, supplemented by inputs from posterior subdivisions of IPS, and the ventral lateral occipital complex (vLOC). Moreover, greater local selectivity was demonstrated in areas near the superior parieto-occipital cortex and dorsal premotor cortex, putatively forming the dorso-dorsal stream. Conclusions: A contribution from aIPS, consistent with its role in prospective grasp formation and/or encoding of relevant tool properties (e.g., potential graspable parts), is likely to accompany the retrieval of manipulation and/or mechanical knowledge subserved by the supramarginal gyrus for achieving action goals. An involvement of vLOC indicates that MVPA is particularly sensitive to coding of object properties, their identities and even functions, for a support of grip formation. Finally, the engagement of the superior parieto-frontal regions as revealed by MVPA is consistent with their selectivity for transient features of tools (i.e., variable affordances) for anticipatory hand postures. These outcomes support the notion that, compared to traditional approaches, MVPA can reveal more fine-grained patterns of neural activity. (JINS, 2018, 24, 1013–1025)