bluuebunny/crossref_metadata_2025 huggingface dataset:
Immune Checkpoint Inhibitors in Malignancies with Mismatch Repair Deficiency: A Review of the State of the Current Knowledge
Authors: Naboush Ali , Roman Christopher A J , Shapira Iuliana
Published: January 2017

The use of immune checkpoint inhibitors to treat malignant tumors with microsatellite instability is an emerging new modality. This is based on the observations that these tumors may have a high mutation rate—thus a potential source of tumor-specific neoantigens—and harbor infiltrating cytotoxic T cells in response, suggesting that they may be particularly susceptible to immune checkpoint therapy. PUBMED and ASCO library were systematically reviewed to identify all relevant data that involved the use of immune checkpoint inhibitors in the treatment of cancers with microsatellite instability. The manual search retrieved a total of 3 relevant articles and 1 abstract published between 2015 and 2016. A total of 61 patients with colorectal, 3 with ampullary/cholangiocarcinoma, 2 with endometrial carcinomas, 3 with small bowel cancers, 2 with glioblastoma multiforme, and 1 with bladder cancer with reported efficacy results were reviewed. All the patients had stage IV cancer and were treated with immune checkpoint inhibitors until progression of disease or intolerable side effects emerged. The range of objective response rate was 25–71%. Responses were also durable with progression-free survival at 20 weeks of around 67–78% and to 46% at 1 year. The use of immune checkpoint inhibitors is effective in cancers that express microsatellite instability.
Correlation and Combination Factors of Wind Forces on Cylindrical Roof Structures
Authors: Chen Bo , Zhong Pengpeng , Cheng Weihua , Chen Xinzhong , Yang Qingshan
Published: January 2017

The correlations among wind pressures on roof and walls are examined for the cylindrical roof buildings with different rise-span ratios based on wind tunnel data. Wind-induced dynamic response is also analyzed with a parametric study concerning span length, rise-span ratio, stiffness of supporting frames and connection type between roof and supporting frames, where the roof system is a single-layer cylindrical reticular shell. For both roof and supporting frames, the responses induced by vertical wind loads on the roof and by horizontal wind loads on the walls are investigated. The correlation coefficients of these response components are examined. The results showed that the fluctuating wind pressure on the roof is strongly correlated with the wind pressure on the side wall and the leeward wall, but weakly correlated with the wind pressure on the windward wall. The response of roof and supporting frames caused by the wind loads on the roof is much larger than that of wind loads on the walls. On the bases of a comprehensive parameter study and complete quadratic combination (CQC) rule, a practical simplified combination rule is suggested for estimating response of roof and supporting frames. It is given as sum of response component caused by wind load on roof and that of wind load on walls multiplied with a combination factor of [Formula: see text].
Using Semantically-Extended LDA Topic Model for Semantic Tagging
Authors: Allahyari Mehdi , Kochut Krys
Published: January 2017

The volume of documents and online resources has been increasing significantly on the Web for many years. Effectively, organizing this huge amount of information has become a challenging problem. Tagging is a mechanism to aggregate information and a great step towards the Semantic Web vision. Tagging aims to organize, summarize, share and search the Web resources in an effective way. One important problem facing tagging systems is to automatically determine the most appropriate tags for Web documents. In this paper, we propose a probabilistic topic model that incorporates DBpedia knowledge into the topic model for tagging Web pages and online documents with topics discovered in them. Our method is based on integration of the DBpedia hierarchical category network with statistical topic models, where DBpedia categories are considered as topics. We have conducted extensive experiments on two different datasets to demonstrate the effectiveness of our method.
Mononuclear phagocyte subpopulations in the mouse kidney
Authors: George James F. , Lever Jeremie M. , Agarwal Anupam
Published: January 2017

Mononuclear phagocytes are the most common cells in the kidney associated with immunity and inflammation. Although the presence of these cells in the kidney has been known for decades, the study of mononuclear phagocytes in the context of kidney function and dysfunction is still at an early stage. The purpose of this review is to summarize the present knowledge regarding classification of these cells in the mouse kidney and to identify relevant questions that would further advance the field and potentially lead to new opportunities for treatment of acute kidney injury and other kidney diseases.
MiR-451 Promotes Cell Proliferation and Metastasis in Pancreatic Cancer through Targeting CAB39
Authors: Guo Rende , Gu Jianhua , Zhang Zhibin , Wang Yi , Gu Chuan
Published: January 2017

Emerging evidence shows that microRNAs (miRNAs) play important roles in the regulation of various biological and pathologic processes in human cancers and the aberrant expression of miRNAs contributes to the tumor development. In this study, our findings indicate that miR-451 is significantly overexpressed in pancreatic cancer tissues and cell lines and elevated expression of miR-451 contributes to promoted cell viability (in vitro and in vivo). Moreover, overexpression of miR-451 is closely linked to poor prognosis and lymphatic metastasis. Inhibition of miR-451 dramatically suppresses cell viability and invasion, promotes cell apoptosis, and induces cell cycle arrest. Furthermore, miR-451 directly targets CAB39 and negatively regulates its expression and inhibition of CAB39 contributes to the promoted cell viability and invasion. Our findings improve our understanding of the function of miR-451 in the identification and therapy of pancreatic cancer.
Toxicity Studies of Ethyl Maltol and Iron Complexes in Mice
Authors: Li Zhen , Lu Jieli , Wu Chonghui , Pang Quanhai , Zhu Zhiwei , Nan Ruipeng , Du Ruochen , Chen Jia
Published: January 2017

Ethyl maltol and iron complexes are products of ethyl maltol and the iron found in the cooking pots used to prepare the Chinese dish, hot-pot. Because their safety is undocumented, the toxicity study of ethyl maltol and iron complexes was conducted in male and female Kunming (KM) mice. The animal study was designed based on the preliminary study conducted to determine the median lethal dose (LD50). The doses used in the study were 0, 1/81, 1/27, 1/9, and 1/3 of the LD50(mg kg body weight (BW)−1day−1) dissolved in the water. The oral LD50of the ethyl maltol and iron complexes was determined to be 743.88 mg kg BW−1in mice. The ethyl maltol and iron complexes targeted the endocrine organs including the liver and kidneys following the 90 D oral exposure. Based on the haematological data, the lowest-observed-adverse-effect level (LOAEL) of the ethyl maltol and iron complexes was determined to be 1/81 LD50(9.18 mg kg BW−1 day−1) in both male and female mice. Therefore, we suggest that alternative strategies for preparing the hot-pot, including the use of non-Fe-based cookware, need to be developed and encouraged to avoid the formation of the potentially toxic complexes.
From Pathogenesis, Clinical Manifestation, and Diagnosis to Treatment: An Overview on Autoimmune Pancreatitis
Authors: Cai Ou , Tan Shiyun
Published: January 2017

Autoimmune pancreatitis (AIP) is a special type of chronic pancreatitis which is autoimmune mediated. The international consensus diagnostic criteria (ICDC) 2011 proposed two types of AIP: type I is associated with histological pattern of lymphoplasmacytic sclerosing pancreatitis (LPSP), characterized by serum IgG4 elevation, whereas type 2 is named idiopathic duct-centric pancreatitis (IDCP), with granulocytic epithelial lesion (GEL) and immunoglobulin G4 (IgG4) negative. The pathogenic mechanism is unclear now; based on genetic factors, disease specific or related antigens, innate and adaptive immunity may be involved. The most common clinical manifestations of AIP are obstructive jaundice and upper abdominal pain. The diagnosis can be made by a combination of parenchymal and ductal imaging, serum IgG4 concentrations, pancreatic histology, extrapancreatic disease, and glucocorticoid responsiveness according to ICDC 2011. Because of the clinical and imaging similarities with pancreatic cancer, general work-up should be done carefully to exclude pancreatic malignant tumor before empirical trial of glucocorticoid treatment. Glucocorticoid is the most common drug for AIP to induce remission, while there still exists controversy on steroid maintenance and treatment for relapse. Further studies should be done to identify more specific serum biomarkers for AIP, the pathogenic mechanisms, and the treatment for relapse.
Basal and Activated Calcium Sensitization Mediated by RhoA/Rho Kinase Pathway in Rats with Genetic and Salt Hypertension
Authors: Behuliak Michal , Bencze Michal , Vaněčková Ivana , Kuneš Jaroslav , Zicha Josef
Published: January 2017

Calcium sensitization mediated by RhoA/Rho kinase pathway can be evaluated either in the absence (basal calcium sensitization) or in the presence of endogenous vasoconstrictor systems (activated calcium sensitization). Our aim was to compare basal and activated calcium sensitization in three forms of experimental hypertension with increased sympathetic tone and enhanced calcium entry—spontaneously hypertensive rats (SHR), heterozygous Ren-2 transgenic rats (TGR), and salt hypertensive Dahl rats. Activated calcium sensitization was determined as blood pressure reduction induced by acute administration of Rho kinase inhibitor fasudil in conscious rats with intact sympathetic nervous system (SNS) and renin-angiotensin system (RAS). Basal calcium sensitization was studied as fasudil-dependent difference in blood pressure response to calcium channel opener BAY K8644 in rats subjected to RAS and SNS blockade. Calcium sensitization was also estimated from reduced development of isolated artery contraction by Rho kinase inhibitor Y-27632. Activated calcium sensitization was enhanced in all three hypertensive models (due to the hyperactivity of vasoconstrictor systems). In contrast, basal calcium sensitization was reduced in SHR and TGR relative to their controls, whereas it was augmented in salt-sensitive Dahl rats relative to their salt-resistant controls. Similar differences in calcium sensitization were seen in femoral arteries of SHR and Dahl rats.
Expression of Cadherin-17 Promotes Metastasis in a Highly Bone Marrow Metastatic Murine Breast Cancer Model
Authors: Okada Tomoko , Kurabayashi Atsushi , Akimitsu Nobuyoshi , Furihata Mutsuo
Published: January 2017

We previously established 4T1E/M3 highly bone marrow metastatic mouse breast cancer cells throughin vivoselection of 4T1 cells. But while the incidence of bone marrow metastasis of 4T1E/M3 cells was high (~80%) when injected intravenously to mice, it was rather low (~20%) when injected subcutaneously. Therefore, using 4T1E/M3 cells, we carried out furtherin vitroandin vivoselection steps to establish FP10SC2 cells, which show a very high incidence of metastasis to lungs (100%) and spines (85%) after subcutaneous injection into mice. qRT-PCR and western bolt analysis revealed that cadherin-17 gene and protein expression were higher in FP10SC2 cells than in parental 4T1E/M3 cells. In addition, immunostaining revealed the presence of cadherin-17 at sites of bone marrow and lung metastasis after subcutaneous injection of FP10SC2 cells into mice. Suppressing cadherin-17 expression in FP10SC2 cells using RNAi dramatically decreased the cells’ anchorage-independent growth and migrationin vitroand their metastasis to lung and bone marrowin vivo. These findings suggest that cadherin-17 plays a crucial role in mediating breast cancer metastasis to bone marrow.
q-Deformed Relativistic Fermion Scattering
Authors: Sobhani Hadi , Chung Won Sang , Hassanabadi Hassan
Published: January 2017

In this article, after introducing a kind ofq-deformation in quantum mechanics, first,q-deformed form of Dirac equation in relativistic quantum mechanics is derived. Then, three important scattering problems in physics are studied. All results have satisfied what we had expected before. Furthermore, effects of all parameters in the problems on the reflection and transmission coefficients are calculated and shown graphically.
Evaluation of Facial Proportions and Their Association with Thumbprint Patterns among Hausa Ethnic Group
Authors: Adamu Lawan Hassan , Ojo Samuel Adeniyi , Danborno Barnabas , Adebisi Sunday Samuel , Taura Magaji Garba
Published: January 2017

Background. Evolutionary forces such as founder effect resulted in reproductive isolation and reduced genetic diversity may have led to ethnic variation in the facial appearance and other features like fingerprints pattern. Aim. To determine the pattern of facial proportion based on neoclassical facial canon. The associations between facial proportions and thumbprint patterns were also investigated. Subject and Methods. A total of 534 subjects of 18–25 years of age participated. Direct sensing and photographs methods were used to determine fingerprint and facial features, respectively. Fisher’s Exact test was used to test for association between variables. Results. It was observed that in both males and females there was no (0%) occurrence of classical canon of facial proportion. There was also no association between sex and facial proportions. A significant association was found in between thumbprint patterns and vertical class III neoclassical facial proportion only when the frequency of both left and right thumbprint patterns was considered a single entity. There is no significant association between the thumbprint patterns of the right and left thumbs with vertical horizontal facial proportions in male and female participants. It was observed that right and left thumbs have more tendency of significance with facial proportion in males and females, respectively. Conclusion. Fingerprint pattern and its associated features may be controlled by a different mechanism such that the two may correlate differently with other features as the case may be with facial features.
Immunohistochemical Phenotype of Breast Cancer during 25-Year Follow-up of the Royal Marsden Tamoxifen Prevention Trial
Authors: Detre Simone I. , Ashley Susan , Mohammed Kabir , Smith Ian E. , Powles Trevor J. , Dowsett Mitch
Published: January 2017

The randomized, double-blinded Royal Marsden Tamoxifen Breast Cancer Prevention Trial in healthy high-risk women started in 1986 and is still blinded. Eligible participants (n = 2,471) were randomly assigned to tamoxifen (20 mg/d) or placebo for 8 years. Analysis in 2006 showed a 30% risk reduction of estrogen receptor (ER)-positive invasive breast cancer mostly in the posttreatment period. Biomarker analysis in this population may identify any subgroup-specific preventive effects tamoxifen. After a median follow-up of 18.4 years, 242 patients had developed invasive cancer, 134 on placebo and 108 on tamoxifen. From these, 180 tissue blocks were available and ER, progesterone receptor (PgR), Ki67, HER2, and EGFR were immunohistochemically analyzed. A 32% reduction in ER+ and PgR+ invasive cancers resulted after 8 years of treatment. Quantitative levels of ER and PgR were lower in the tamoxifen-treated group, significantly so for ER (P = 0.001). These lower ER levels were restricted to the posttreatment period (P = 0.018). Among the ER+ group, there was a similar proportional decrease in PgR+ and PgR− tumors by tamoxifen. The median levels of Ki67 were similar in both arms. The numbers of HER2-positive and EGFR-positive cancers were higher in the tamoxifen arm but not significantly so. In conclusion, the preventive effects of tamoxifen result in reduced ER-positive but not ER-negative tumors and reduced ER expression in the ER-positive cases largely confined to the posttreatment period. Overall reductions in PgR expression are explained by lower frequency of ER-positive cases. Impact on Ki67, HER2, and EGFR was modest. Cancer Prev Res; 10(3); 171–6. ©2017 AACR.
Requirements for Septal Localization and Chromosome Segregation Activity of the DNA Translocase SftA from Bacillus subtilis
Authors: El Najjar Nina , Kaimer Christine , Rösch Thomas , Graumann Peter L.
Published: January 2017

Bacillus subtilis possesses 2 DNA translocases that affect late stages of chromosome segregation: SftA separates nonsegregated DNA prior to septum closure, while SpoIIIE rescues septum-entrapped DNA. We provide evidence that SftA is associated with the division machinery via a stretch of 47 amino acids within its N-terminus, suggesting that SftA is recruited by protein-protein interactions with a component of the division machinery. SftA was also recruited to mid-cell in the absence of its first 20 amino acids, which are proposed to contain a membrane-binding motif. Cell fractionation experiments showed that SftA can be found in the cytosolic fraction, and to a minor degree in the membrane fraction, showing that it is a soluble protein in vivo. The expression of truncated SftA constructs led to a dominant sftA deletion phenotype, even at very low induction rates of the truncated proteins, indicating that the incorporation of nonfunctional monomers into SftA hexamers abolishes functionality. Mobility shift experiments and surface plasmon binding studies showed that SftA binds to DNA in a cooperative manner, and demonstrated low ATPase activity when binding to short nucleotides rather than to long stretches of DNA.
Lung Nodule with Increasing Fluorodeoxyglucose Uptake in a Patient with a History of Lung Carcinoma and Talc Pleurodesis Evaluated by EBUS-TBNA On-Site Assessment
Authors: Kurian Elizabeth M.
Published: January 2017

Background: Fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET) scan is an indicator of potential malignancy or infection. Patients with a history of talc pleurodesis can develop pleural or lung parenchymal nodules/talcomas. In these patients, talc-associated (non-malignancy-related) FDG uptake may occur over years. Case Report: A 66-year-old female presented with a past medical history significant for resected non-small-cell lung cancer and was treated with chemotherapy/radiation. The referring physician indicated that she subsequently developed benign pleural effusions and had talc pleurodesis to limit recurrence. The patient was referred to our institution for endobronchial ultrasound-guided transbronchial fine-needle aspiration (EBUS-TBNA) due to a new left upper lobe nodule with increasing FDG uptake on follow-up interval PET performed at the referring institution. On-site cytologic evaluation showed no evidence of malignancy, but found refractile foreign material, consistent with the presence of talc particles. Conclusion: This case presents the importance of cytologic recognition of talc particles during on-site evaluation and discusses the phenomenon of increasing PET-FDG uptake associated with talc pleurodesis.
Azathioprine Hypersensitivity Syndrome: Two Cases of Febrile Neutrophilic Dermatosis Induced by Azathioprine
Authors: Aleissa Majed , Nicol Perrine , Godeau Marion , Tournier Emilie , de Bellissen Frederic , Robic Marie-Angèle , Bulai Livideanu Cristina , Mazereeuw-Hautier Juliette , Paul Carle
Published: January 2017

Background: Azathioprine is an immunosuppressive agent used in the treatment of immune-mediated diseases. Azathioprine hypersensitivity syndrome is a rare adverse reaction occurring a few days to weeks after the administration of azathioprine. Case 1: A 36-year-old male with ulcerative colitis presented with erythematous plaques, pustules and erosions on the lower back, buttocks and thighs associated with high fever (39°C) 2 weeks after the initiation of azathioprine 100 mg/day. Additional findings included leukocytosis (18.6 g/L) with neutrophilia (11.1 g/L) and elevated C-reactive protein (128 mg/L). Histopathology showed a dense infiltrate of neutrophils in the hair follicles. We increased the dose of prednisone to 1 mg/kg/day (60 mg/day) and azathioprine was discontinued. He had marked improvement within 3 weeks and did not have any relapse with a 1-year follow-up. Case 2: A 57-year-old male with ulcerative colitis presented with erythematous plaques and pustules on the lower limbs associated with high fever (40°C) 1 week after the initiation of azathioprine 75 mg/day. Leukocytosis with neutrophilia (13.6 g/L) and elevated C-reactive protein (344 mg/L) were among the laboratory findings. Histopathology showed a dense infiltrate of neutrophils in the hair follicles. The dose of prednisone was increased to 20 mg/day and azathioprine was discontinued, which led to complete remission within 7 days. He did not have any relapse with a 6-month follow-up. Conclusion: The development of acute neutrophilic dermatitis 2 weeks after the initiation of azathioprine and the complete resolution after its withdrawal were in favor of azathioprine hypersensitivity syndrome. It should not be confused with Sweet syndrome associated with inflammatory bowel disease, as maintenance of azathioprine treatment may lead to life-threatening reactions.
Neurotoxicity following the Ingestion of Bilimbi Fruit (Averrhoa bilimbi) in an End-Stage Renal Disease Patient on Hemodialysis
Authors: Caetano Camille Pereira , de Sá Cinara Barros , Faleiros Bruno Antônio Paixão , Gomes Marcelo Fonseca Coutinho Fernandes , Pereira Edna Regina Silva
Published: January 2017

Introduction: The toxic effects of the ingestion of star fruit (Averrhoa carambola) in chronic kidney disease patients are well described in the literature. Recently, the compound caramboxin has been isolated, explaining the mechanisms of its neurotoxicity. Bilimbi fruit belongs to the family Oxalidaceae, Averrhoa bilimbi species, and exhibits similar biochemical characteristics to star fruit. Objective: To report the case of a patient with chronic kidney disease who developed a seizure disorder after the ingestion of bilimbi fruit. Case Report: A 69-year-old man with chronic kidney disease on hemodialysis therapy had intractable hiccups, myoclonus, and generalized tonic-clonic seizures after the consumption of a moderate amount of bilimbi fruit. The electroencephalogram showed a pattern of seizure disorder despite the use of anticonvulsant drugs. Renal replacement therapy was maintained during the whole period and prescribed according to the patient’s hemodynamic status. Despite showing clinical resolution of the seizure disorder, the patient died on the 27th day of hospitalization for infectious complications. Conclusions: The neurologic status without any other known cause and with clear temporal association with the ingestion of the fruit suggests the diagnosis of neurotoxicity. We propose the hypothesis that the bilimbi fruit has neurotoxic effects similar to those exhibited by the star fruit.
Muscone Induces CYP1A2 and CYP3A4 Enzyme Expression in L02 Human Liver Cells and CYP1A2 and CYP3A11 Enzyme Expression in Kunming Mice
Authors: Liu Sha , Cheng Yujie , Rao Menglin , Tang Mi , Dong Zhi
Published: January 2017

Aim: To examine the effect of synthetic muscone on the expression of CYP1A2 and CYP3A4 enzymes in human liver L02 cells and in the liver tissue of Kunming mice. Methods: The L02 hepatic cell line was used to study the effect of low (10-4 μmol/L), middle (10-3 μmol/L), and high concentrations (10-2 μmol/L) of muscone on the expression of CYP1A2 and CYP3A4 enzymes. In addition, the cytochrome P450 (CYP) expression was investigated in Kunming mice after the administration of 10 mg/kg (low), 50 mg/kg (middle), and 100 mg/kg (high) dose of muscone for 6 days. A mixture of phenobarbital (30 mg/kg) and β-napthoflavone (80 mg/kg) was used as positive control and the effects of the compounds on CYP expression were investigated at the end of 6- and 12-day periods. Results: Muscone induced the expression of CYP1A2 (middle and low concentrations) and of CYP3A4 (high concentration) enzymes in L02 cells. In vivo, administration of muscone in Kunming mice revealed significant weight reduction at the end of 6- and 12-day periods (middle and high doses, respectively), compared to the control group (p < 0.05). Liver toxicity scores indicated that the liver injuries in the positive control and high doses of muscone group were significantly higher in the 6- and 12-day periods, compared to those in the blank control group (p < 0.05). Furthermore, muscone induced CYP1A2 and CYP3A11 expressions in Kunming mice at the middle dose and all doses during the 12-day period as demonstrated by immunoblotting experiments. A low dose of mucone induced the CYP enzyme expression more rapidly, whereas a high dose of muscone caused the longest inductive effect. The results were confirmed by immunohistochemistry experiments and real-time PCR studies, where similar patterns of muscone-mediated inductive effects were noted. Conclusions: Muscone induces CYP1A2 and CYP3A4 expression in liver cells in vitro and in vivo. In addition, it exhibits liver toxicity in Kunming mice at concentrations higher than 50 mg/kg. The CYP-inductive effect that is caused by muscone encompasses a 6- to 12-day period of activity after drug administration as demonstrated by follow-up in vivo studies.
Recurrent Malignant Melanoma Presenting as Isolated Pleural Metastases in a Patient with Chronic Lymphocytic Leukemia
Authors: Anand Kartik , Cingam Shashank , Peddi Prakash
Published: January 2017

Isolated pleural metastasis with pleural effusion is a rare occurrence in malignant melanoma. We report an unusual case of a patient with chronic lymphocytic leukemia (CLL) and recurrent pleural effusions. The pleural fluid cytology and immunohistochemistry profile were consistent with the diagnosis of CLL. However, chemotherapy with pentostatin, cyclophosphamide, and rituximab did not result in any meaningful clinical response. A video-assisted thoracoscopic surgery and biopsy of the affected nodular parietal layer of the pleura were consistent with malignant melanoma. Our case underlines the importance of having a suspicion for secondary causes of effusion in patients with CLL. We briefly discuss the mechanisms of an increased incidence of secondary cancers in CLL and the diagnosis of isolated pleural metastases in malignant melanoma.
Role of Insulin in Placental Transport of Nutrients in Gestational Diabetes Mellitus
Authors: Ruiz-Palacios María , Ruiz-Alcaraz Antonio José , Sanchez-Campillo María , Larqué Elvira
Published: January 2017

Background: Gestational diabetes mellitus (GDM) is associated with increased fetal adiposity, which may increase the risk of obesity in adulthood. The placenta has insulin receptors and maternal insulin can activate its signaling pathways, affecting the transport of nutrients to the fetus. However, the effects of diet or insulin treatment on the placental pathophysiology of GDM are unknown. Summary: There are very few studies on possible defects in the insulin signaling pathway in the GDM placenta. Such defects could influence the placental transport of nutrients to the fetus. In this review we discuss the state of insulin signaling pathways in placentas of women with GDM, as well as the role of exogenous insulin in placental nutrient transport to the fetus, and fetal adiposity. Key Messages: Maternal insulin in the third trimester is correlated with fetal abdominal circumference at that time, suggesting the important role of insulin in this process. Since treatment with insulin at the end of pregnancy may activate placental nutrient transport to the fetus and promote placental fatty acid transfer, it would be interesting to improve maternal hyperlipidemia control in GDM subjects treated with this hormone. More research in this area with high number of subjects is necessary.
Designing of Medical processor unit for Intelligent network-based Medical usage
Authors: MOHAMMED ABDUL AZEEM
Published: January 2017

This medical design conventions of books and deductive method (MPU). the development of research and the success of many already, we have found the cause of architecture MPU. On the unique features of the processor in question it is coded in different areas of medicine (MOPC). working from a very close bilateral processor MPU. Each issue has a special feature code for the hardware supply chain on the steps and produce a special version of the code and the victim (s). Illness, Doctor MOPC mph dismounted and made a series of sub-processes, and to launch the second law of medical devices. If the computer system of a victim and has a specific digital for logic, and victims of medical devices that operate in the blood, tissues, operating theaters, medical staff, medical costs and variables, etc. We follow the process that the patient design of medical networks and overlapping and development computer.
Identification of Brain disorders by Sub-band Decomposition of EEG signals and Measurement of Signal to Noise Ratio
Authors: Ullah Hadaate , Mahmud Shahin , Chowdhury Rubana Hoque
Published: January 2017

In the case of medical science, one of the most restless researches is the identification of abnormalities in brain. Electroencephalogram (EEG) is the main tool for determining the electrical activity of brain and it contains rich information associated to the varieties physiological states of brain. The purpose of this task is to identify the EEG signal as order or disorder. It is proposed to enrich an automated system for the identification of brain disorders. An EEG signal of a patient has been taken as a sample. The simulation has been done by MATLAB. The file which consists of the signal has been called in and plotted the signals in MATLAB. The proposed system covers pre-processing, feature extraction, feature selection and classification. By the pre-processing the noises are ejected. In this case the signal has been filtered using band pass filter. The Discrete Wavelet Transform (DWT) has been used to decompose the EEG signal into Sub-band signal. The feature extraction methods have been used to extract the EEG signal into frequency domain and the time domain features. The SNR (Signal to Noise ratio) is obtained in this work is 1.1281dB.
Combined Beamforming with Orthogonal Space Time Block Code for MIMO-OFDM with Simple Feedback
Authors: M. Abd Elkader Hala , M. Abdel-Hamid Gamal , El-Dien Adly Tag , A. Nassif Asmaa
Published: January 2017

In this paper, we introduce a proposed scheme to enhance the performance of orthogonal space time block code (OSTBC) with four time slots and two antennas by combing OSTBC with random beamforming to can use it in the downlink transmission for a mobile system.  Multiple-input multiple-output orthogonal frequency-division multiplexing (MIMO-OFDM) system has been recognized as one of the most promising techniques to achieve a good service and increase data rate in the next generation (4&5G) broadband wireless communications. So, we apply Space time block code (STBC) for MIMO-OFDM system with linear decoding.  Also, we perform STBC with beamforming for MIMO-OFDM system to improve the performance of a system. Simulation results show that the beamforming improves bit error rate (BER) performance of OSTBC and STBC-OFDM for different types of modulation and diversity.
Query Optimization Using Fuzzy Logic in Integrated Database
Authors: Susana Susana , Suharjito Suharjito
Published: January 2017

Query optimization in integrated database can’t be separated from data processing method.  In order to have faster query response time, a method to optimize queries is required.  One of many methods that can be used for query optimization is using fuzzy logic with Tsukamoto inference system.  Value set on each variable is defined membership functions and Tsukamoto inference system used in determining these rules or the terms of query results, then apply it into query method or query line structure.  The application of fuzzy logic inference systems with Tsukamoto can accelerate query response time, and will have more significant difference when the amount of selected data is greater.
Disparities in the Use of Seizure Medications After Intracerebral Hemorrhage
Authors: Naidech Andrew M. , Toledo Paloma , Prabhakaran Shyam , Holl Jane L.
Published: January 2017

Background and Purpose—

We investigated potential disparities in the use of prophylactic seizure medications in patients with intracerebral hemorrhage.

Methods—

Review of multicenter electronic health record (EHR) data with simultaneous prospective data recording. EHR data were retrieved from HealthLNK, a multicenter EHR repository in Chicago, Illinois, from 2006 to 2012 (multicenter cohort). Additional data were prospectively coded (single-center cohort) from 2007 through 2015.

Results—

The multicenter cohort comprised 3422 patients from 4 HealthLNK centers. Use of levetiracetam varied by race/ethnicity (
P
=0.0000008), with whites nearly twice as likely as blacks to be administered levetiracetam (odds ratio: 1.71; 95% confidence interval, 1.43–2.05;
P
<0.0001). In the single-center cohort (n=450), hematoma location, older age, depressed consciousness, larger hematoma volume, no alcohol abuse, and race/ethnicity were associated with levetiracetam administration (
P
≤0.04). Whites were nearly twice as likely as blacks to receive levetiracetam (odds ratio: 1.9; 95% confidence interval, 1.25–2.89;
P
=0.002); however, the association was confounded by history of hypertension, higher blood pressure on admission, and deep hematoma location. Only hematoma location was independently associated with levetiracetam administration (
P
<0.00001), rendering other variables, including race/ethnicity, nonsignificant.

Conclusions—

Although multicenter EHR data showed apparent racial/ethnic disparities in the use of prophylactic seizure medications, a more complete single-center cohort found the apparent disparity to be confounded by the clinical factors of hypertension and hematoma location. Disparities in care after intracerebral hemorrhage are common; however, administrative data may lead to the discovery of disparities that are confounded by detailed clinical data not readily available in EHRs.
Control of Meloidogyne paranaensis in coffee plants mediated by silicon
Authors: Roldi Miria , Dias-Arieira Claudia Regina , da Silva Santino A. , Dorigo Orazília F. , Machado Andressa Cristina Zamboni
Published: January 2017

Coffee plants are considerably affected by the presence ofMeloidogynespp. and management is based in the use of resistant rootstocks. Systemic induced resistance could constitute an option to manageMeloidogyne paranaensisin coffee-growing areas. Coffee seedlings cv. Mundo Novo were treated with silicate before the inoculation ofM. paranaensisto evaluate the potential control of this pathogen. We found, 120 days after the inoculation of 2000 eggs, that the application of silicate was effective to reduce the nematode population, based on reproduction factor and number of nematodes per g roots. Based on the present results, we suggest that the application of silicon constitutes an important alternative for the management ofM. paranaensisin infested coffee-growing areas. Further studies are necessary to clarify the biochemical and molecular relationships betweenM. paranaensisand coffee in the presence of silicon.
Introduction
Authors: Kōdera Tsukasa , Saito Tatsuya , Soda Megumi , Aitken Geneviève
Published: January 2017

The exhibition of Japanese prints held at the École des Beaux-Arts in Paris in 1890 is a milestone in the history of Japonisme. Organized by S. Bing in collaboration with a number of Japonistes, the exhibition presented more than 1100 Japanese prints, illustrated books and kakemono. This article reconstructs this historic event in its diverse aspects: clarifying the preparation process, reconstructing the exhibition venue, identifying exhibits, and examining their lenders. All these factors will be placed in a historical context, revealing how meticulously Bing prepared the exhibition and subsequently promoted ukiyo-e prints in France. The impact of this exhibition on artists and critics, which is clearly visible in artists’ letters and contemporary reviews published in the press, is also briefly discussed.
Parablechnum roraimense and P. paucipinna spp. nov. (Blechnaceae: Polypodiopsida), lectotypification of P. stuebelii, and citation corrections in the family
Authors: DITTRICH VINÍCIUS ANTONIO DE OLIVEIRA , SMITH ALAN R. , GASPER ANDRÉ LUÍS DE
Published: January 2017

We describe here two new species of Parablechnum from the Neotropics. One of them, P. roraimense, was discovered as a result of visits to the herbaria BM, K, P, PR, and S, as part of the Reflora Project, by the first author. The other new species, P. paucipinna, is from eastern Venezuela. Additionally, we lectotypify a very distinctive Parablechnum, P. stuebelii described from Colombia, now known also from Ecuador and Peru. Finally, we correct five combinations in the family.
Amended diagnosis of the genus Nannodiaptomus (Copepoda, Calanoida), based on redescription of N. phongnhaensis and description of a new species from caves in central Vietnam
Authors: TRAN DUC LUONG , BRANCELJ ANTON
Published: January 2017

Nannodiaptomus phongnhaensis Dang & Ho, 2001, an endemic stygobiotic diaptomid from Vietnam and the type species of the genus Nannodiaptomus Dang & Ho, 2001, is redescribed on the basis of a new material from its type locality: Hang Phong Nha Cave, Quang Binh province, central Vietnam. We also designated a neotype, because the type material has been lost. The diagnosis of the genus is amended, based on the description of the neotype. The taxonomic position of the genus in the subfamily Speodiaptominae is proposed, and its relationships with other genera of this subfamily are discussed. A new cave-dwelling species Nannodiaptomus haii sp. nov., from a cave near the type locality of N. phongnhaensis, is also described and illustrated. The new species differs from the type species of the genus, among other things, by the structure of male’s left swimming leg 5, where the inner margin of the apical process and the sub-terminal seta on the swimming leg 5 Exp-2 have small serrated membranes, but these bear 3–4 distinct denticular protrusions in N. phongnhaensis.
A new species and the shallowest record of Flabegraviera Salazar-Vallejo, 2012 (Annelida: Flabelligeridae) from Antarctica
Authors: JIMI NAOTO , TSUJIMOTO MEGUMU , WATANABE KENTARO , KAKUI KEIICHI , KAJIHARA HIROSHI
Published: January 2017

A new species of polychaete, Flabegraviera fujiae sp. nov., is described and the first report of F. mundata (Gravier, 1906) from the shallow water around Syowa Station, Antarctica, is presented. Flabegraviera fujiae sp. nov. resembles F. profunda Salazar-Vallejo, 2012 but is discriminated from the latter by having eyes and an exposed cephalic cage. The specimen of F. mundata was collected from a depth of 8 m, providing the shallowest record of this species to date.
Description of the imago of Neocapritermes utiariti (Isoptera: Termitidae: Termitinae)
Authors: AZEVEDO RENATO A. , SOBRAL RAFAEL , DAMBROS CRISTIAN S. , MORAIS JOSÉ W. DE
Published: January 2017

The neotropical termite genus Neocapritermes Holmgren (1912) was revised by Krishna & Araujo (1968), who recognized 14 valid species. Two additional species were described by Constantino (1991), and another one by Bandeira & Cancello (1992). However, the imago of most species of Neocapritermes remain unknown. In this paper we describe for the first time the imago of Neocapritermes utiariti based on specimens from the State of Rondônia, Brazil. The examined material will be deposited in the Invertebrate Collection of the Instituto Nacional de Pesquisas da Amazônia, in Manaus, Amazonas, Brazil (INPA). Comparisons with other imagoes of Neocapritermes were made based on descriptions and figures from Krishna & Araújo (1968). The measurements were taken with an ocular micrometer following Roonwal’s (1970) system of morphometric characters.
Followup in Psychoanalysis: What Happens to Treatment Gains?
Authors: Wallerstein Robert S.
Published: January 2017

A recent panel (1989) discussed the feasibility and the desirability of systematic post-treatment followup study of psychoanalytic patients. In this paper, I compare the data bearing on these issues from the Menninger Foundation Psychotherapy Research Project, headed by me, and the Boston Institute Project, headed by Kantrowitz, and I indicate why their data are neither comparable nor adequate enough to warrant the conclusion that their apparent discrepant findings—that in the Menninger project outcome at termination tended to be predictive of the subsequent followup course, while in the Boston project this was not so—are more than chance events. I then present detailed case descriptions of two patients from the Menninger project who were quite similar in character and in illness structure, had seemingly comparable analytic courses, and similar good therapeutic results, but had quite different followup courses, one with further consolidation, and the other with regression. I present some of the determinants of this difference.
Language and the Psychoanalytic Process: Psychoanalysis and Vygotskian Psychology, Part II
Authors: Wilson Arnold , Weinstein Lissa
Published: January 2017

This paper follows our previous one, where we described a psychoanalytic conception of language, thought, and internalization that is informed by the thinking of Lev Vygotsky. Here, several aspects of the analytic process which allow for the understanding of ineffable experiences in the analysand's history and the analytic situation are investigated: specifically, primal repression, metaphor, and the role of speech in free association. It is suggested that Freud's notion of primal repression be revived and redefined as one aspect of the descriptive unconscious. Some implications of primal repression for transference and resistance are explored. The metaphoric in its broad sense is examined as one example of how early dynamic experiences embedded in the process of language acquisition can be reached within the clinical situation. It is proposed that an understanding of free association is enhanced by awareness of distinctions between inner, egocentric, and social speech. The basic rule can be interpreted as an invitation for the analysand to use inner speech in collaboration with the analyst as best he or she can. Further, the aliveness and degree of superficiality of the analysis can be seen as a function of the analyst's ability to appreciate the properties of inner speech and foster the conditions in the analysis that allow for its unfolding.
Freudian and Kleinian Theory: A Dialogue of Comparative Perspectives
Authors: Pulver Sidney E. , Levine Howard B.
Published: January 2017

In his opening remarks, Pulver reviewed Kernberg's (1969) critique of Kleinian theory and outlined some of the significant events in the life of Melanie Klein: early object losses and subsequent depressions, relocations from Budapest to Berlin to London, and analyses with Ferenczi and Abraham.
The Home as a Career Education Center
Authors: Simpson Elizabeth J.
Published: January 2017

As a result of the increasing sophistication of our communication technology, a new role for the home as a learning center is developing. The home as a learning center can serve the purposes of developing children's concepts of work and leisure; training young persons and adults for occupational competency; preparing older workers for new careers; developing competencies of men and women for their homemaking and family life responsibilities; serving in unique ways the career education needs of exceptional children; and promoting personal development and a sense of worth for persons of all ages. Career education in the home is a way to provide for increased learning opportunity for many people for an entire lifetime.
Estimation of the Center of Simulated Planetary Bodies
Authors: Weltman Gershon
Published: January 2017

The task of centering the simulated image of a planetary body on a display representing the viewscreen of a satellite was investigated in a study employing both male and female subjects. It was found that task performance, as measured by relative radial error, is significantly poorer for crescent and gibbous bodies than for full-phase bodies, and that a circular screen is significantly better than a rectangular one. No significant difference appears for the three diameters of planetary image which were tested. There occur large differences among individuals within the subject group, and the male group exhibits lower error scores than the female. The best subject performed at a level of approximately 1 per cent estimation for all conditions. This amount of operator error is theoretically compatible with the requirements for attitude control during the re-entry of a satellite vehicle.
A Predictive Scale of Aircraft Emergencies
Authors: Rigby Lynn V. , Edelman David A.
Published: January 2017

In the quantification of human performance, the effects of stress can be dealt with objectively only if one first determines the relative stress-producing value of different conditions within the given operational environment. This paper presents a paired comparision scale of 32 common aircraft emergencies judged by 27 former pilots and aircrew members. The scale is intended primarily for use in human error analysis. A new emergency can be incorporated by matching it to one or more points on the scale, or the scale can be transformed to satisfy any new interpretation of the relationship between emergencies and stress.
Effectiveness of Filters in Improving Air-to-Ground Target Identification Performance on a Television Display
Authors: Johnston Dorothy M.
Published: January 2017

The purpose of this study was to determine if the utilization of filters would improve target identification performance on a television display. Inflight video tape was obtained of convoys of vehicular targets under different meteorological visibility conditions while using two types of filters and a no-filter condition on the television camera. The video tape was used in the laboratory for dynamic presentations on a television display. Analysis of variance revealed with five miles visibility no reliable difference in target identification slant ranges between filters 15 and 29, but reliable differences between filter 15 and no filter, and between filter 29 and no filter. With seven miles meteorological visibility reliable differences in target identification performance were found between all combinations of the conditions investigated. Maximum mean improvements in performance were as follows: with five miles visibility filter 15 increased target identification range 2600 feet farther than the no-filter condition. With seven miles visibility filter 29 increased target identification range 3685 feet feet farther than the no-filter condition.
Detection Time to a Point Source of Light Appearing on a Star Field Background with and without a Glare Source Present
Authors: Haines Richard F.
Published: January 2017

One hundred and twenty seven untrained observers were tested in a planetarium in order to determine how long it takes to detect the onset of a point source of light appearing at different locations within a star field with and without a veiling glare source present. Results indicated that detection time was shortest when test spots were flashed in a totally dark visual environment. Introduction of a simulated star field produced significantly longer detection times as did the introduction of a star field and glare source. These results are related to findings from previous investigations as well as to certain sighting situations performed in the aerospace environment.