bluuebunny/crossref_metadata_2025 huggingface dataset:
La enseñanza del diseño: una práctica pedagógica en renovación
Authors: Gómez Vera Laura Teresa
Published: June 2021

En este artículo se busca abrir una reflexión para promover la renovación en las prácticas pedagógicas de la enseñanza del diseño. Para ello, se expone la metodología que formula la gestión de la tecnología al tener un carácter emprendedor y promover el “pensamiento complejo como uno de los saberes que es urgente sumar en todos y cada uno de los ambientes educativos” (Morin, 1999). Su principio racional hace que el individuo adquiera o construya su propia experiencia para responder, con base en un conocimiento multidimensional, a las causas y efectos que pueda presentar cada situación problemática para hacer posible el desarrollo y la transferencia de las innovaciones hacia la sociedad.
La autobiografía: enamorar a los estudiantes universitarios en la escritura académica
Authors: Ríos Nava Bernabé , Olivo Estrada José Ramón
Published: June 2021

Se presenta la experiencia didáctica vivida con estudiantes del cuarto semestre de la carrera de Médico Cirujano, de la Unidad Académica de Medicina de la Universidad Autónoma de Nayarit, en la unidad de aprendizaje Ensayo Científico (EC), estrategia que trata de acercar al estudiante en la dinámica de la construcción de documentos de corte científico; conocer y reconocer su estructura, descubrir sus detalles y, sobre todo, iniciarse en la escritura.La autobiografía parece el género ideal para responder a las interrogantes de ¿cómo relacionar la escritura académica con las actividades de los estudiantes en sus espacios clínicos? y ¿cómo hacer de la escritura una actividad atractiva?, así como para despertar tanto la imaginación como la motivación de los participantes; además de observar su potencial para lograr distintos propósitos.
La relevancia del ámbito docente en la formación integral del licenciado en Filosofía en el Plan de Estudios 2016
Authors: Luján Salazar Enrique , Zamora Díaz María Gabriela
Published: June 2021

Este artículo hace referencia a la particular orientación docente del plan de estudios de Filosofía aprobado en 2016. Se recupera la importancia de la formación pedagógica del profesor para que atienda a los problemas actuales de la enseñanza de la filosofía. Para enriquecer la formación de los egresados de esta licenciatura se da cuenta de los nuevos programas y usar recursos educativos implementados en el plan que permitan propiciar aprendizajes significativos de la filosofía, así como, diseñar e implementar proyectos y actividades de difusión para la promoción de la cultura y el pensamiento filosóficos a través de diferentes medios y recursos físicos y virtuales dentro y fuera de los ámbitos académicos. Estas líneas pretenden dar cuenta de la enorme relevancia que tiene la docencia en filosofía para nuestro mundo actual y la recuperación que de ella se hace como un espacio formativo en el nuevo plan de estudios de Filosofía.
Una reflexión sobre el aprendizaje de los profesores
Authors: Chávez Ruiz Yolanda
Published: June 2021

Una de las preguntas obligadas que debemos plantearnos cuando nos encontramos como profesores frente a un grupo de estudiantes es: ¿cómo aprenden nuestros alumnos?; sin embargo, al parecer, esta reflexión no es tan recurrente, ya que cuando hablamos de aprendizaje, es muy probable que lo que viene a nuestra mente es una aula con bancas en fila, al frente un pizarrón y, dominando este recurso, a un profesor que comunica lo que pretende que aprenda un grupo de estudiantes, mismo que, en ocasiones, se piensa ellos “ignoran”. Muy probablemente una de las situaciones que menos nos planteamos es: ¿cómo aprendemos los profesores en la práctica docente?, ya que poco reflexionamos sobre estas cuestiones; sin embargo, el aprendizaje de los profesores es un tema de interés reciente en la investigación (Bransford, Brown & Cocking, 2004).
Plataformas educativas para apoyar la formación docente
Authors: (DEFAA) Departamento de Formación y Actualización Académica
Published: June 2021

La formación docente es una actividad que requiere de una actualización constante, con el fin de buscar innovar la educación y lograr una mejor calidad en diversas áreas de la misma, como la utilización de diversos recursos didácticos para lograr dicho propósito. Por ello, en Ver y leer, le presentamos algunas opciones que podrán ser de utilidad para mejorar su labor en el aula: Coursera, Índice de Revistas Mexicanas de Divulgación Científica y Tecnológica, Recursos  en línea para el alumnado de inglés y The Flipped Classroom.
Breve mirada al contexto educativo internacional y la necesidad de la participación docente en un ciclo de mejora continua
Authors: (DEFAA) Departamento de Formación y Actualización Académica
Published: June 2021

El contexto internacional actual nos confronta con una sinergia global, contenida en una red de complejas interacciones, que afecta las predicciones de futuro en todos los ámbitos, incluyendo el educativo. Ello nos obliga a flexibilizarnos como individuos y como organizaciones a cualquier nivel, para lograr una adaptación adecuada con el entorno local, nacional e internacional (Gershenson, 2016). Ante este panorama, toma relevancia el papel de los docentes, actores principales de la educación (junto con los estudiantes) (UAA, 2007), de quienes se espera una adaptación más inmediata, flexible y creativa, entre otros rasgos, que les permita contribuir desde los espacios educativos, en la construcción de soluciones y alternativas equitativas, incluyentes y sustentables, con las cuales se aborden las diversas problemáticas presentes en el entorno.
A promising German-Mexican cooperation for music education and research
Authors: Carbajar Vaca Irma Susana , Kreutz Gunter
Published: June 2021

Con el propósito de ampliar la internacionalización de la educación superior, en junio de 2016, la Universidad Autónoma de Aguascalientes (UAA) y la Universidad de Oldenburg, Alemania firmaron un convenio de cooperación académica. Esto lo realizan el Departamento de Música de la UAA y el Instituto para la Música de la Universidad de Oldenburg, cuyo director es la Profa. Dra. Susanne Binas-Preisendörfer, experta en Música y Medios de Comunicación. El contacto principal para realizar el acuerdo fue el Prof. Dr. Gunter Kreutz, especialista en Ciencias Sistemáticas de la Música y actual subdirector del Instituto. Este acuerdo de cooperación surgió oportunamente en el contexto del Año Dual Alemania-México (Ministerio Federal de Relaciones Exteriores et al. 2016), como un evento institucional que tendrá un impacto en los objetivos de internacionalización de la UAA.
El profesor de bachillerato: concepciones, retos y logros
Authors: Ornelas Rodríguez Gustavo , Valencia García María Antonieta , Guerrero Rodríguez Marthelena
Published: June 2021

Los datos estatales (IEA, 2016) señalan que en el ciclo escolar 2010-2011 se inscribieron en el nivel 46 505 alumnos, mientras que en el ciclo escolar 2015-2016 la cifra es de 60 451 (29 879 hombres y 30 572 mujeres), cabe hacer notar que sólo en el municipio de Aguascalientes cursan este nivel 44 078 chicos, lo que habla de un aumento considerable en la matrícula; estos alumnos están inscritos en 310 planteles y son atendidos por una planta de 3 350 docentes.
La buena educación: nociones del alumnado de un bachillerato universitario acerca de la calidad educativa
Authors: Heredia Soberanis Norma Graciella , Peniche Cetzal Rubí Surema
Published: June 2021

Bajo la ideología neoliberal que domina actualmente el campo de la educación formal, el término “calidad” está presente en la redacción de metas y objetivos estratégicos incluidos en los planes institucionales, por lo que técnicamente representa un macrocriterio para evaluarla. Para Gago (2002), usar sólo el término “calidad”, sin ningún calificativo que lo acompañe, es ambiguo, ya que mencionar que algo es de calidad es una obviedad, pues todo tiene calidad, aunque sea mala. Este autor señala que lo fundamental de la evaluación radica en el adjetivo que ha de agregarse al sustantivo “calidad”, por lo que encontrar el adjetivo más adecuado, es decir, la calificación correcta y verdadera de la calidad de algo, es el propósito de la evaluación; de tal forma que al hablar de la calidad de los programas educativos, lo deseable es contar con procesos evaluativos transparentes y precisos en sus paradigmas, enfoques y métodos, para que los resultados que revelen sean creíbles, válidos y confiables.
El debate como recurso pedagógico: propuesta estratégica para un aprendizaje integral
Authors: Del Moral Palacio José Ángel
Published: June 2021

Una estrategia común en los procesos de enseñanza y aprendizaje es el debate; sin embargo, tanto en el aula como en el espacio público esta práctica se convierte en una forma de ganar o imponer la opinión propia a la ajena, o en un caos sonoro sin sentido, por lo que es necesaria una auténtica formación para debatir. Con tal propósito, a partir de categorías tomadas de la teoría de los juegos y de la ética discursiva, el presente texto describe una experiencia al respecto, llevada a cabo en el Bachillerato de la Universidad Autónoma de Aguascalientes.
La formación docente para la enseñanza en la Universidad Autónoma de Aguascalientes
Authors: (DEFAA) Departamento de Formación y Actualización Académica
Published: June 2021

El Modelo Educativo Institucional (MEI) de la Universidad Autónoma de Aguascalientes es el principal referente de la educación que en ella se imparte. En él se establecen las directrices más relevantes para lograr una formación integral y humanista, a partir de su concepción socioconstructivista centrada en el educando y acorde con las tendencias educativas del siglo XXI. Para lograr la implementación de procesos de enseñanza y aprendizaje, con base en los preceptos del MEI, es indispensable que la formación de los profesores sea integral y equilibrada entre el saber pedagógico y didáctico para su aplicación y el de sus áreas de especialización en cuanto a las disciplinas que imparten.
Predictores académicos de desempeño en una Licenciatura en Música
Authors: Correa Juan Pablo , Moreno Martínez Rodolfo Raphael
Published: June 2021

En este artículo se presenta una revisión de la literatura sobre predictores académicos de desempeño en el pregrado. Se enfatizan las variables evaluadas durante los procesos de admisión de programas de estudios musicales. A manera de conclusión, se proponen algunas preguntas que pueden guiar proyectos de investigación que exploren el potencial predictivo de variables, como el promedio de bachillerato, el puntaje del EXANI II, y las pruebas de admisión específicas al campo musical. Asimismo, se argumenta sobre la importancia de tener en cuenta las experiencias formativas preuniversitarias en el contexto mexicano, debido a las áreas de oportunidad que presenta la formación básica en música.
Protocolo para el diseño de exámenes extraordinarios
Authors: Morales Mireles Adriana , Torres Landa López Alejandra , Ramos Solórzano Gabriela
Published: June 2021

Este artículo es resultado de un miniproyecto de investigación denominado “Protocolo para el diseño de exámenes extraordinarios”. El propósito es contar con criterios para el diseño e implementación de los exámenes extraordinarios en las materias del Departamento de Teoría y Métodos del Centro de Ciencias del Diseño y de la Construcción de la Universidad Autónoma de Aguascalientes [UAA]. Se partió del diagnóstico aleatorio del estado actual de los exámenes extraordinarios como instrumentos de medición para la evaluación del aprendizaje de los estudiantes, cuando éstos no han logrado alcanzar una calificación aprobatoria al final de un curso. Se tuvo como referentes institucionales el Modelo Educativo Institucional [MEI] y el Reglamento General de Docencia de la UAA [RDG].
About Law Enforcement
Authors: Kozhevnikov Vladimir Valentinovich
Published: June 2021

The article examines a number of features of law enforcement in the law enforcement sphere. In particular, the author touched upon the subject composition of law enforcement activities, as well as its participants (victims, witnesses, etc.), on whose legal activity the effectiveness of law enforcement activities largely depends. Attention is drawn to the professional and psychological culture of law enforcement entities, to the regulatory framework of law enforcement, and its peculiarities. stages, structure of law enforcement acts.
In vitro antioxidant activity of the methanolic extract of leaves of a hill tract plant Begonia roxburghii
Authors: Akter Taslima , Nawar Afra , Alam Md Nur , Md Rafiquzzaman -
Published: June 2021

The study was designed to investigate the antioxidant activities of the methanolic extract of leaves of Begonia roxburghii by five different in vitro methods namely Folin-Ciocalteu, total flavonoid content, phosphomolybdenum, total reducing power determination, and DPPH scavenging activity. Phenol content (Gallic acid equivalent) was found as 180.40±0.03 mg/g of the dry sample by the Folin-Ciocalteu method. Flavonoid assay method revealed the content of flavonoids (Quercetin equivalent) as 60.43±0.27 mg/g of the dry sample. Total antioxidant capacity of the extract was observed 243.43±0.11 mg/g ( ascorbic acid equivalent) by phosphomolybdenum method. Free radical scavenging activity (measured by the DPPH test) of the methanolic extract was found 158.36±0.22 μg/mL whereas ascorbic acid, the standard, showed 19.53±0.04 μg/mL. The methanolic extract of Begonia roxburghii leaves exhibited positive and linear dose dependent reducing power activity and its activity was comparable to the standard ascorbic acid for a given dose. Phytochemical screening of the extract showed positive results for alkaloids, carbohydrates, flavonoids, glycosides, saponins, steroids, and tannins, which demonstrate definite pharmacological actions on human body. The extract showed negative results for the steroids.

Jahangirnagar University J. Biol. Sci. 9(1 & 2): 79-89, 2020 (June & December)
Global Impact and Implications of Covid-19: Call for Multi-Dimensional Perspectives towards Sustainable Solutions
Authors: Rahube Teddie O.
Published: June 2021

The COVID-19 pandemic poses an enormous challenge, and it is evidently presenting itself as one of the greatest threats to humanity. The aim of this paper is to review the current state of the COVID-19 pandemic, the global health impact and implications of COVID-19 relative to other recent viral disease outbreaks and antimicrobial resistance (AMR), with the aim to propose the implementation of sustainable solutions. The magnitude of COVID-19 deaths is incomparable to other coronaviruses (CoVs) disease outbreaks experienced in recent history. The high number of deaths observed in developed countries compared to developing countries may have been triggered by the late response/preparedness to the pandemic rather than by the socio-economic statuses. CoVs will remain a serious health threat to humanity due to absence of vaccines and anti-viral treatments. The absence of specific treatment regimens also lead to heavy reliance on chemical disinfectants and could significantly contribute to the rise in AMR, further raising some important questions surrounding hygiene, microbes, ecosystem health and human diseases. The CEASE approach, comprising of five key elements; Communication, Education, Advocacy, Socialization, and Experimentation is proposed for implementation at a global level. CEASE approach is critical especially for African countries and can be used to further explore opportunities that can lead to improvements in sanitation, access to clean water, health care, education and infectious disease surveillance systems.
Pharmacophore Investigations of Potential COVID-19 RNA Polymerase (Rdrp) Inhibitors: Repurposing FDA-Approved Drugs
Authors: Kouznetsova Valentina L. , Kellogg Caroline , Zhang Aidan , Tatineni Mahidhar , Miller Mark A. , Tsigelny Igor F.
Published: June 2021

Authors: Valentina L. Kouznetsova, Caroline Kellogg, Aidan Zhang, Mahidhar Tatineni, Mark A. Miller, Igor F. Tsigelny Background: SARS-CoV-2 has caused tens of millions of infections worldwide and millions of deaths. Currently, no effective treatment has been identified against the virus. Of its viral proteins, the RNA-dependent RNA polymerase (RdRp) is a promising target for drug design because of its importance in the replication of the virus. Material and Methods: After the identification of an RdRp pocket site based on the crystal structure of the RdRp– nsp7–nsp8 complex and the triphosphate form of remdesivir (PDB ID: 7BV2), we created a pharmacophore model consisting of 11 different features. These features include two acceptors, three donors, one acceptor and donor, three donor or acceptor, and one hydrophobic; an excluded volume of R=1.1 Å was also added. We then ran a pharmacophore search on our conformational database (DB) of approximately 2500 FDA-approved drugs and 600 000 conformations to identify potential drug-candidates. To determine the drugs that bound the best, we conducted multi conformational docking of these results to the previously identified pocket site. Results: The pharmacophore search found 315 different potential inhibitors of RdRp, of which 85 were chosen based on the number of H-bonds and hydrophobic interactions in the best docking pose. Several of the drugs selected, including ritonavir, dasatinib, imatinib, and sofosbuvir, have previously been shown to be effective against other viruses. Conclusions: These findings highlight compounds that could lead to both in vitro and in vivo studies to identify potential treatments against SARS-CoV-2.
Production of enzymatic complex from agro-industrial biomass and its application in combustible ethanol
Authors: Arruda Adam Gonçalves , Evangelista Igor Vieira , Menezes Larissa Soares de , Fischer Janaína , Cardoso Vicelma Luiz , Santos Líbia Diniz , Guidini Carla Zanella
Published: June 2021

Waste biomass and agro-industrial by-products, for production ethanol, will meet much of the great demand for this product. To reduce costs and optimize production, this study investigated solid-state fermentation (SSF) to obtain crude enzyme complex (CEC) from different agro-industrial biomasses (sugarcane bagasse, corn peel bran, rice straw bran and roasting and ground coffee residue) using cellulolytic fungi. The most promising CEC were evaluated in simultaneous hydrolysis and fermentation (SHF) for ethanol production by Saccharomyces cerevisiae in a culture broth containing sugarcane bagasse treated by steam explosion, and roast and ground coffee residue. In SSF with bioreactor volume of 0.25 L, containing 40 g of the biomass mixture and 40 g of sterile water with resuspended cells (1.0 x108 spores/g of solid medium) and temperature of 30±2 ºC, the strains Trichoderma reesei and Penicilium oxalicum provided the best enzyme activity. The CEC of T. reesei provided a concentration of 7.5 g L-1 of ethanol in a substrate containing treated sugarcane bagasse (60%) and roast and ground coffee residue (40%), under SHF conditions (pH 4.5, 35±2 °C, 48 h). The results obtained in this study show a promising alternative for correct disposal and use of residues and agro-industrial by-products by use in the production of enzymes and lignocellulosic ethanol.
Solução de conflitos: Acordo ou sentença
Authors: Oliveira Isabel Lima dos Santos , Santos Renato Lima dos , Pereira Alex Gomes , Fernandes Fábio Herrera , Silva Rafael Luis da , Braga Marcus Vinicius Oliveira
Published: June 2021

Novas formas de flexibilização das relações de trabalho têm se disseminado, dentre as quais a autocomposição, que se estabelece dentro dos tribunais brasileiros como uma solução para dirimir o problema da morosidade na tramitação e procedimento processuais. Com o advento da resolução 125/10, que objetiva a utilização de novas formas de solução de conflitos, voltadas à construção do consenso, bem como da Lei nº 13.105, de 16 de março de 2015, O Novo CPC, que trouxe diversas inovações ao sistema processual brasileiro e uma das que mais chamam a atenção é justamente a audiência de conciliação. Um novo horizonte se constituiu. Surge assim, a perspectiva da institucionalização da obrigatoriedade da autocomposição. Propõe-se que além de amenizar a morosidade processual, ascende o acesso à justiça e vem para modificar a cultura da sentença, no sentido de que é oportunizado às partes, a resolução de suas lides, onde a um terceiro imparcial é imposta a missão de tentar aproximar os interesses de ambas, orientando-as na formação de um acordo, sem fugir aos princípios norteadores do processo. O judiciário tem tomado diversas iniciativas para acomodar-se a tais mudanças. O estudo tem como objetivo principal a análise das vantagens entre o acordo na audiência de conciliação ou a espera de uma decisão na sentença judicial, verificando se o tempo processual em ambos os casos. Além do mais, a conciliação tem como objetivo buscar o modo mais célere de resolver a controvérsia, possibilitando um maior acesso à justiça.
Dengue, Zika Fever e Chikungunya: Aspectos Biológicos e Situação na América do Sul entre 2015 e 2020
Authors: Silva Raquel Bezerra da , Araujo Maria Isabela Ferreira de , Barbosa Paula Perazzo de Souza
Published: June 2021

Arboviroses são doenças causadas por vírus transmitidos por artrópodes e afetam as Américas, incluindo a América do Sul, onde provocam impactos na economia e na saúde pública. Entre os mais de 500 vírus registrados no Catálogo Internacional de Arbovírus, destacam-se os que causam dengue, febre zika e chikungunya. Assim, este artigo compreende um estudo descritivo baseado em dados secundários, onde são comparados aspectos biológicos e diagnósticos em relação a essas três enfermidades, bem como avaliamos sua presença, entre 2015 e 2020, nos países que integram a porção continental sul-americana. Apesar do considerável progresso feito nos últimos anos para melhor compreender os aspectos moleculares dos agentes etiológicos e das condições clínicas, o cenário é complexo e os três arbovírus causaram surtos na América do Sul, no período descrito, em proporções diferentes, e a dengue a mais comum, cujas taxas de incidência variam a cada ano analisado. O combate aos arbovírus deve ser permanente e requer políticas intersetoriais bem fundamentadas e responsabilidade individual. As intervenções governamentais precisam estreitar-se para implementar medidas de combate, e os sistemas de saúde e educação poderiam se alinhar de forma mais eficaz a fim de um trabalho mais forte de sensibilização que seja desencadeado desde os alunos da educação básica, auxiliando na educação continuada da população a favor da uma sociedade mais orientada e prudente. Também é necessário refletir sobre a eficácia dos sistemas de informações a fim de minimizar o problema da subnotificação, que impede de mostrar o real cenário dessas doenças.
Ação educativa em saúde desenvolvida com trabalhadoras de materiais recicláveis
Authors: Vorpagel Kalinka Moraes , Pedroso Ariane Francieli Teixeira , Ortiz Carla Penteado , Ajala Jéssica Aires , Schein Jéssica Luísa , Silva Karoline Silva da , Graube Sandra Leontina , Bittencourt Vivian Lemes Lobo , Lucca Jane Conceição Perin
Published: June 2021

As mulheres catadoras exercem papel significativo no ciclo da reciclagem de materiais, e através do seu trabalho promovem a sustentabilidade do planeta, na tentativa de diminuir resíduos sólidos. Devido a essa situação, ficam expostas a riscos ocupacionais que influenciam diretamente em sua saúde e sexualidade. O objetivo do estudo é relatar uma ação educativa em saúde desenvolvida com trabalhadoras de materiais recicláveis sobre transformações corporais nas fases da vida de mulheres. Trata-se de um relato de experiência, de abordagem qualitativa, descritiva, aplicada e desenvolvida em uma cooperativa de reciclagem da região Noroeste do estado do Rio Grande do Sul, com sete trabalhadoras de material reciclável, com idades entre 18 e 40 anos. Percebeu-se que estas mulheres apresentam poucos conhecimentos sobre o próprio corpo, relataram dúvidas quanto à utilização dos métodos contraceptivos e sobre o funcionamento do sistema reprodutor feminino, mas demonstram autoestima e aceitação em relação à sua imagem corporal. As ações educativas desenvolvidas pela enfermagem, com esta classe de trabalhadores, auxiliam no despertar de um olhar mais abrangente da sociedade e das diversas classes sociais, em uma atuação profissional que busca um cuidado humanizado e igualitário.
Corrosion characterization of the experimental alloy Ti-35Nb-7Zr-5Ta by electrochemical techniques
Authors: Italiano Ana Elisa Vilicev , Amantéa Daniela Vieira , Silva Fernando Santos da , Fernandes Leandro , Santos Márcio Luiz dos , Vaz Luís Geraldo
Published: June 2021

The objective of the present study was to evaluate the corrosion resistance of the experimental alloy Ti-35Nb-7Zr-5Ta, modified by laser beam, in a physiological solution of 0.9% NaCl. This evaluation was carried out by open circuit potential analysis (EOCP), potentiodynamic polarization curves and cyclic polarization curves. The open circuit potential curves show the specimen irradiated by laser beam at 35 Hz presented a more stable and corrosion resistant surface. It was observed in the polarization curves, low current densities in the order of nA /cm2, for all specimen indicating an expected passive behavior for the investigated alloy. The cyclic polarization curves show that for specimen treated with laser, the potential for repassivation (Er) is greater in relation to the potential for corrosion (Ecorr), which indicates greater resistance to corrosion of metal alloys when treated with laser.
Terapia medicamentosa segura: perspectivas da enfermagem e da farmácia no cuidado de paciente em Unidade de Terapia Intensiva (UTI)
Authors: França Dayane Lins , Castro Tailaine Nascimento de , Nobre Valdjane Nogueira Noleto
Published: June 2021

Diante do número alarmante de eventos adversos relacionados a medicamentos no âmbito da Unidade de Terapia Intensiva (UTI), ações efetivas no cuidado do paciente são necessárias. Nessa perspectiva, este trabalho tem como objetivo discutir o papel da enfermagem e da farmácia quanto à utilização segura de medicamentos, visando garantir a qualidade da assistência prestada a pacientes críticos. Foi realizada uma revisão integrativa, de caráter exploratório-descritivo com abordagem qualitativa, na qual resultou na seleção de 21 artigos, publicados entre janeiro e abril de 2021, indexados nas principais bases de dados.  A partir dos estudos analisados, observou-se que os principais eventos adversos estavam relacionados a erros de prescrição, preparo e administração; ocorrência de interações medicamentosas; incompatibilidades entre drogas e equipamentos. O surgimento desses problemas foi associado à falha de comunicação da equipe multiprofissional, a sobrecarga de trabalho e a falta de conhecimento sobre farmacodinâmica e farmacocinética da droga. Portanto, faz-se necessário a integração e articulação de enfermeiros e farmacêuticos para que a farmacoterapia seja efetiva, segura e assertiva, mediante a complexidade projetada na prática, demandando desses profissionais maior capacitação e treinamento.
DOMESTIC VIOLENCE AMID LOCKDOWN: A SHADOW PANDEMIC
Authors: Singh Abhimanyu , Kumar Raj
Published: June 2021

The outbreak of global pandemic has not just exposed people to the virus but other factors like domestic violence as well. The aim of this research paper is to highlight the major causes of the increase in the domestic violence during the lockdown. The approach of the research has been both theoretical as well as empirical. Domestic violence has been referred to the abuse by one intimate partner on the other. This domestic abuse can be for various unethical reasons or dissatisfactions pointed out by the abuser and his family. The research has also laid down the key elements of abuse in order to recognize whether the act is abuse or not. Intimidation, humiliating each other, Excessive Control and Physical Injury are the four major key elements. There are various causes for the increase domestic violence however financial instability, unemployment, stress, illiteracy, lack of efficiency of NGOs.
Immune Infiltrates of m6A RNA Methylation-Related lncRNAs and Identification of PD-L1 in Patients With Primary Head and Neck Squamous Cell Carcinoma
Authors: Feng Zi-Yi , Gao Hao-Yu , Feng Tian-Da
Published: June 2021

Background: The purpose of this study was to determine the association between m6A-modified lncRNAs, immune infiltration, and PD-L1 expression in patients with primary head and neck squamous cell carcinoma (HNSCC) and the prognostic value of m6A RNA methylation-related lncRNAs in HNSCC.

Methods: We downloaded the RNA-seq transcriptome data and the clinical information for HNSCC from the TCGA databases and used consensus clustering analysis to divide the samples into two groups. To identify a risk signature, least absolute shrinkage and selection operator (LASSO) analyses were conducted. the association between m6A-modified lncRNAs, immune infiltration, and PD-L1 expression were detected by using the R packages. What is more, we used cBioPortal tools to identify genomic alterations and PD-L1 mutations and Gene set enrichment analysis (GSEA) was utilized to predict downstream access of two clusters.

Results: Notably, lncRNAs play significant roles in tumorigenesis and development. In total, we identified two subtypes of HNSCC according to consensus clustering of the m6A RNA methylation-related lncRNAs, and the T, grade and age were proven to be related to the subtypes. The Cox regression and LASSO analyses identified a risk signature including GRHL3-AS1, AL121845.4, AC116914.2, AL513190.1. The prognostic value of the risk signature was then proven. The selected gene PD-L1 mutations and the immune infiltration in both groups were further explored.

Conclusion: Collectively, our study elucidated the important role of m6A RNA methylation- related lncRNAs in tumor microenvironment of HNSCC. The proposed m6A RNA methylation- related lncRNAs might serve as crucial mediators of tumor microenvironment of HNSCC, representing promising therapeutic targets in improving immunotherapeutic efficacy.
β1-Blockers Enhance Inotropy of Endogenous Catecholamines in Chronic Heart Failure
Authors: Feuerstein Thomas J. , Schlicker Eberhard
Published: June 2021

Although β1-blockers impressively reduce mortality in chronic heart failure (CHF), there are concerns about negative inotropic effects and worsening of hemodynamics in acute decompensated heart failure. May receptor theory dispel these concerns and confirm clinical practice to use β1-blockers? In CHF, concentrations of catecholamines at the β1-adrenoceptors usually exceed their dissociation constants (KDs). The homodimeric β1-adrenoceptors have a receptor reserve and display negative cooperativity. We considered the binomial distribution of occupied receptor dimers with respect to the interaction of an exogenous β1-blocker and elevated endogenous agonist concentrations > [KDs], corresponding to an elevated sympathetic tone. Modeling based on binomial distribution suggests that despite the presence of a low concentration of the antagonist, the activation of the dimer receptors is higher than that in its absence. Obviously, the antagonist improves the ratio of the dimer receptors with only single agonist activation compared with the dimer receptors with double activation. This leads to increased positive inotropic effects of endogenous catecholamines due to a β1-blocker. To understand the positive inotropic sequels of β1-blockers in CHF is clinically relevant. This article may help to eliminate the skepticism of clinicians about the use of β1-blockers because of their supposed negative inotropic effect, since, on the contrary, a positive inotropic effect can be expected for receptor-theoretical reasons.
Holocene Lake Evolution and Glacial Fluctuations Indicated by Carbonate Minerals and Their Isotopic Compositions in the Sediments of a Glacial Melt Recharge Lake on the Northwestern Tibetan Plateau
Authors: Li Minghui , Zhu Liping , Wang Junbo , Ju Jianting , Liu Chong , Ma Qingfeng , Xu Teng , Qiao Baojin , Wang Xiaoxiao
Published: June 2021

Lakes and glaciers are widely distributed on the Tibetan Plateau and are linked via hydrological processes. They are experiencing rapid changes due to global warming, but their relationships during the Holocene are less well known due to limited coupled geological records. Here, we analyzed the δ13C-VPDB and δ18O-VPDB values and ion content of calcite and aragonite in a 407-cm-long sediment core from Guozha Co, a closed basin on the northwestern Tibetan Plateau supplied by glacial meltwater, in order to understand how the lake responded to glacier changes during the Holocene. Our results indicate that the glacial meltwater lowered the lake’s temperature and the δ18Olake water and δ18Oendogenic + authigenic carbonate values and diluted the ion concentrations in the lake water. Three stages of evolution, 8.7–4.0, 4.0–1.5, and 1.5 kyr BP to present, are distinguished based on the decrease in glacial meltwater recharge. Guozha Co has been a closed basin since at least 8.7 kyr BP, and it has changed from a fresh water lake during 8.7–1.5 kyr BP to a brackish lake from 1.5 kyr BP to present due to several climate events. The famous 4.2 kyr BP cold event was identified in the core at 4.0 kyr BP, while warm events occurred at 6.2, 3.9, 2.2, 0.9, and 0.4 kyr BP. Both glaciers and lakes in this area are controlled by climate, but they exhibit opposite changes, that is, glaciers retreat and lakes expand, and vice versa. Our results provide an accurate interpretation of the cold events based on carbonate minerals and carbon–oxygen isotopes in glacial meltwater–recharged lake sediments.
Black Women’s Labor and White Ally Development in an Urban Teacher Education Program
Authors: Coleman-King Chonika , Anderson Brittany N. , Koerber Nathan
Published: June 2021

The article uses events and narratives from the perspectives of Black women professors as examples of how allyship can be birthed and to illustrate the roles, responsibilities, and risks inherent in allyship development and work. It focuses on the labor needed to establish and sustain allyship as critical anti-racist educators in an Urban Teacher Preparation Program at a Historical White Institution. Dispositions of White allies are discussed, in addition to the various tensions allies may face in creating and sustaining equitable spaces and practices. Considerations for reciprocity are also offered to better support faculty of color.
Identification of Gonadulin and Insulin-Like Growth Factor From Migratory Locusts and Their Importance in Reproduction in Locusta migratoria
Authors: Veenstra Jan A. , Leyria Jimena , Orchard Ian , Lange Angela B.
Published: June 2021

Many insect species have several genes coding for insulin-related peptides (IRPs), but so far only a single IRP gene has been identified in migratory locusts. Here, we report and characterize two other genes coding for peptides that are related to insulin, namely gonadulin and arthropod insulin-like growth factor (aIGF); peptides postulated to be orthologs of Drosophila melanogaster insulin-like peptides 8 and 6 respectively. In Locusta migratoria the aIGF transcript is expressed in multiple tissues as was previously reported for IRP in both L. migratoria and Schistocerca gregaria, but there are significant differences in expression patterns between the two species. The gonadulin transcript, however, seems specific to the ovary, whereas its putative receptor transcript is expressed most abundantly in the ovary, fat body and the central nervous system. Since the central nervous system-fat body-ovary axis is essential for successful reproduction, we studied the influence of gonadulin on vitellogenesis and oocyte growth. A reduction in the gonadulin transcript (via RNA interference) led to a significant reduction in vitellogenin mRNA levels in the fat body and a strong oocyte growth inhibition, thus suggesting an important role for gonadulin in reproduction in this species.
An Integrated Food, Energy, and Water Nexus, Human Well-Being, and Resilience (FEW-WISE) Framework: New Mexico
Authors: Yadav Kamini , Geli Hatim M. E. , Cibils Andres F. , Hayes Michael , Fernald Alexander , Peach James , Sawalhah Mohammed N. , Tidwell Vincent C. , Johnson Lindsay E. , Zaied Ashraf J. , Gedefaw Melakeneh G.
Published: June 2021

Interconnected food, energy, and water (FEW) nexus systems face many challenges to support human well-being (HWB) and maintain resilience, especially in arid and semiarid regions like New Mexico (NM), United States (US). Insufficient FEW resources, unstable economic growth due to fluctuations in prices of crude oil and natural gas, inequitable education and employment, and climate change are some of these challenges. Enhancing the resilience of such coupled socio-environmental systems depends on the efficient use of resources, improved understanding of the interlinkages across FEW system components, and adopting adaptable alternative management strategies. The goal of this study was to develop a framework that can be used to enhance the resilience of these systems. An integrated food, energy, water, well-being, and resilience (FEW-WISE) framework was developed and introduced in this study. This framework consists mainly of five steps to qualitatively and quantitatively assess FEW system relationships, identify important external drivers, integrate FEW systems using system dynamics models, develop FEW and HWB performance indices, and develop a resilience monitoring criterion using a threshold-based approach that integrates these indices. The FEW-WISE framework can be used to evaluate and predict the dynamic behavior of FEW systems in response to environmental and socioeconomic changes using resilience indicators. In conclusion, the derived resilience index can be used to inform the decision-making processes to guide the development of alternative scenario-based management strategies to enhance the resilience of ecological and socioeconomic well-being of vulnerable regions like NM.
High Genetic Heterogeneity in Chinese Patients With Waardenburg Syndrome Revealed by Next-Generation Sequencing
Authors: Zhang Sen , Xu Hongen , Tian Yongan , Liu Danhua , Hou Xinyue , Zeng Beiping , Chen Bei , Liu Huanfei , Li Ruijun , Li Xiaohua , Zuo Bin , Tang Ryan , Tang Wenxue
Published: June 2021

Objective

This study aimed to explore the genetic causes of probands who were diagnosed with Waardenburg syndrome (WS) or congenital sensorineural hearing loss.

Methods

A detailed physical and audiological examinations were carried out to make an accurate diagnosis of 14 patients from seven unrelated families. We performed whole-exome sequencing in probands to detect the potential genetic causes and further validated them by Sanger sequencing in the probands and their family members.

Results

The genetic causes for all 14 patients with WS or congenital sensorineural hearing loss were identified. A total of seven heterozygous variants including c.1459C > T, c.123del, and c.959-409_1173+3402del of PAX3 gene (NM_181459.4), c.198_262del and c.529_556del of SOX10 gene (NM_006941.4), and c.731G > A and c.970dup of MITF gene (NM_000248.3) were found for the first time. Of these mutations, we had confirmed two (c.1459C > T and c.970dup) are de novo by Sanger sequencing of variants in the probands and their parents.

Conclusion

We revealed a total of seven novel mutations in PAX3, SOX10, and MITF, which underlie the pathogenesis of WS. The clinical and genetic characterization of these families with WS elucidated high heterogeneity in Chinese patients with WS. This study expands the database of PAX3, SOX10, and MITF mutations and improves our understanding of the causes of WS.
Winter-Spring Development of the Zooplankton Community Below Sea Ice in the Arctic Ocean
Authors: Hop Haakon , Wold Anette , Meyer Amelie , Bailey Allison , Hatlebakk Maja , Kwasniewski Slawomir , Leopold Peter , Kuklinski Piotr , Søreide Janne E.
Published: June 2021

The impact of the rapidly changing Arctic on zooplankton community structure and seasonal behaviour is not yet understood. Here we examine 6 months of under-ice zooplankton observations from the N-ICE2015 expedition (January to June 2015) in the Nansen Basin and on the Yermak Plateau north of Svalbard. Stratified sampling in the water column was done with MultiNet during the entire expedition, and sampling in the upper 5 m below sea ice was performed during April-May by divers using a hand-held net. Hydrographic conditions were dominated by northward-flowing warm and saline Atlantic Water at intermediate depth, and southward-flowing cold Polar Surface Water in the upper 100 m. The mesozooplankton was dominated by copepods. Most numerous were the small ubiquitousOithona similisin the upper 200 m, withMicrocalanusspp. andTriconia borealisfurther down the water column.Calanus finmarchicusdominated among theCalanusspecies whileMetridia longawas also numerous. The most abundant deep-water copepods wereParaeuchaetaspp. andSpinocalanusspp. Arrow worms (Chaetognatha) and comb jellies (Ctenophora) were the most numerous non-copepods. The mesozooplankton community was more dependent on surrounding water mass characteristics, such as salinity and depth, than geographical location. Algal food availability, which was closely linked to seasonality, explained the community changes seen in surface waters in May and June due to seasonal ascent and recruitment. Seasonal changes from winter to spring mostly involved an increase in the herbivorousC. finmarchicusand its nauplii in the upper 200 m of the water column coinciding with the peak of the phytoplankton bloom in late May. The Yermak Plateau and adjacent Nansen Basin were characterised by oceanic North Atlantic and Arctic species, many of which are deep water specialists. Despite the late onset of the spring bloom due to consolidated sea ice, both North Atlantic and Arctic species successfully reproduced in the study area. This explains the species-rich mesozooplankton community in this region as opposed to the less productive central Arctic Ocean. Future prospects of less sea ice and earlier onset of the bloom will likely be positive for the overall secondary production by both Arctic and boreal zooplankton in this region.
Urate Crystals; Beyond Joints
Authors: Ahmad Muhammad Israr , Masood Salman , Furlanetto Daniel Moreira , Nicolaou Savvas
Published: June 2021

Gout is the most common inflammatory arthropathy caused by the deposition of monosodium urate (MSU) crystals. The burden of gout is substantial with increasing prevalence of gout globally. The prevalence of Gout in the United States has increased by over 7% in the last two decades. Initially, it was believed that MSU crystal deposits occur only in the joints with the involvement of the periarticular soft tissues, but recent studies have shown the presence of MSU crystal deposition in extra-articular sites as well. Human plasma becomes supersaturated with uric acid at 6.8 mg/dl, a state called hyperuricemia. Beyond this level, uric acid crystals precipitate out of the plasma and deposit in soft tissues, joints, kidneys, etc. If left untreated, hyperuricemia leads to chronic gout characterized by the deposition of tophi in soft tissues such as the joints, tendons, and bursae. With the advent of newer imaging techniques such as DECT, MSU crystals can be visualized in various extra-articular sites. Extra-articular deposition of MSU crystals is believed to be the causative factor for the development of multiple comorbidities in gout patients. Here, we review the literature on extra-articular deposition of urate crystals and the role of dual-energy computed tomography (DECT) in elucidating multi-organ involvement. DECT has emerged as an invaluable alternative for accurate and efficient MSU crystal deposition detection. Future studies using DECT can help determine the clinical consequences of extra-articular deposition of MSU in gout patients.
A Non-invasive Model for Predicting Liver Inflammation in Chronic Hepatitis B Patients With Normal Serum Alanine Aminotransferase Levels
Authors: Li Xiaoke , Xing Yufeng , Zhou Daqiao , Xiao Huanming , Zhou Zhenhua , Han Zhiyi , Sun Xuehua , Li Shuo , Zhang Ludan , Li Zhiguo , Zhang Peng , Zhang Jiaxin , Zhang Ningyi , Cao Xu , Zao Xiaobin , Du Hongbo , Tong Guangdong , Chi Xiaoling , Gao Yueqiu , Ye Yong'an
Published: June 2021

Background and Aims: Chronic hepatitis B (CHB) patients with normal alanine aminotransferase (ALT) levels are at risk of disease progression. Currently, liver biopsy is suggested to identify this population. We aimed to establish a non-invasive diagnostic model to identify patients with significant liver inflammation.

Method: A total of 504 CHB patients who had undergone liver biopsy with normal ALT levels were randomized into a training set (n = 310) and a validation set (n = 194). Independent variables were analyzed by stepwise logistic regression analysis. After the predictive model for diagnosing significant inflammation (Scheuer's system, G ≥ 2) was established, a nomogram was generated. Discrimination and calibration aspects of the model were measured using the area under the receiver operating characteristic curve (AUC) and assessment of a calibration curve. Clinical significance was evaluated by decision curve analysis (DCA).

Result: The model was composed of 4 variables: aspartate aminotransferase (AST) levels, γ-glutamyl transpeptidase (GGT) levels, hepatitis B surface antigen (HBsAg) levels, and platelet (PLT) counts. Good discrimination and calibration of the model were observed in the training and validation sets (AUC = 0.87 and 0.86, respectively). The best cutoff point for the model was 0.12, where the specificity was 83.43%, the sensitivity was 77.42%, and the positive likelihood and negative likelihood ratios were 4.67 and 0.27, respectively. The model's predictive capability was superior to that of each single indicator.

Conclusion: This study provides a non-invasive approach for predicting significant liver inflammation in CHB patients with normal ALT. Nomograms may help to identify target patients to allow timely initiation of antiviral treatment.