bluuebunny/crossref_metadata_2025 huggingface dataset:
miRNA-Profiling in Ejaculated and Epididymal Pig Spermatozoa and Their Relation to Fertility after Artificial Insemination
Authors: Martinez Cristina A. , Roca Jordi , Alvarez-Rodriguez Manuel , Rodriguez-Martinez Heriberto
Published: February 2022

MicroRNAs (miRNAs) are short non-coding RNAs (20–25 nucleotides in length) capable of regulating gene expression by binding -fully or partially- to the 3’-UTR of target messenger RNA (mRNA). To date, several studies have investigated the role of sperm miRNAs in spermatogenesis and their remaining presence toward fertilization and early embryo development. However, little is known about the miRNA cargo in the different sperm sources and their possible implications in boar fertility. Here, we characterized the differential abundance of miRNAs in spermatozoa from the terminal segment of the epididymis and three different fractions of the pig ejaculate (sperm-peak, sperm-rich, and post-sperm rich) comparing breeding boars with higher (HF) and lower (LF) fertility after artificial insemination (AI) using high-output small RNA sequencing. We identified five sperm miRNAs that, to our knowledge, have not been previously reported in pigs (mir-10386, mir-10390, mir-6516, mir-9788-1, and mir-9788-2). Additionally, four miRNAs (mir-1285, mir-92a, mir-34c, mir-30), were differentially expressed among spermatozoa sourced from ejaculate fractions and the cauda epididymis, and also different abundance was found between HF and LF groups in mir-182, mir-1285, mir-191, and mir-96. These miRNAs target genes with key roles in fertility, sperm survival, immune tolerance, or cell cycle regulation, among others. Linking the current findings with the expression of specific sperm proteins would help predict fertility in future AI-sires.
Role of EPA in Inflammation: Mechanisms, Effects, and Clinical Relevance
Authors: Crupi Rosalia , Cuzzocrea Salvatore
Published: February 2022

Many chronic inflammatory processes are linked with the continuous release of inflammatory mediators and the activation of harmful signal-transduction pathways that are able to facilitate disease progression. In this context atherosclerosis represents the most common pathological substrate of coronary heart disease, and the characterization of the disease as a chronic low-grade inflammatory condition is now validated. The biomarkers of inflammation associated with clinical cardiovascular risk support the theory that targeted anti-inflammatory treatment appears to be a promising strategy in reducing residual cardiovascular risk. Several literature data highlight cardioprotective effects of the long-chain omega-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA). This PUFA lowers plasma triglyceride levels and has potential beneficial effects on atherosclerotic plaques. Preclinical studies reported that EPA reduces both pro-inflammatory cytokines and chemokines levels. Clinical studies in patients with coronary artery disease that receive pharmacological statin therapy suggest that EPA may decrease plaque vulnerability preventing plaque progression. This review aims to provide an overview of the links between inflammation and cardiovascular risk factors, importantly focusing on the role of diet, in particular examining the proposed role of EPA as well as the success or failure of standard pharmacological therapy for cardiovascular diseases.
Nature as a Source of Inspiration for the Structure of the Sydney Opera House
Authors: Rey-Rey Juan
Published: February 2022

Architects throughout the ages have looked to nature for answers to complex questions about the most appropriate structural forms for their buildings. This is the case of Jørn Utzon and the design of roof shells of the Sydney Opera House, in which the search for natural references was constant, from the nautical references in the initial design phases to the final spherical solution based on the analogy with an orange. This paper analyzes the influence of nature as a source of inspiration in this World Heritage building, assessing through FEM calculation models the suitability of the different solutions proposed and weighing up the influence of certain factors such as scale in this type of process. Through the calculation models developed, it has been possible to verify the poor performance of the initial designs compared to the power of the final solution, which, after more than 5 years of research by the design team headed by Utzon, was able to solve the enormous problem with a “simple” typological and geometric change.
Human Ultrasound Neuromodulation: State of the Art
Authors: Beisteiner Roland
Published: February 2022

The first human applications of ultrasound in medicine date back to 1939, when Reimar Pohlmann (Berlin, Germany) published data on therapy of neuralgia with ultrasound [...]
Use of Parsing Heuristics in the Comprehension of Passive Sentences: Evidence from Dyslexia and Individual Differences
Authors: Stella Marianna , Engelhardt Paul E.
Published: February 2022

This study examined the comprehension of passive sentences in order to investigate whether individuals with dyslexia rely on parsing heuristics in language comprehension to a greater extent than non-dyslexic readers. One hundred adults (50 dyslexics and 50 controls) read active and passive sentences, and we also manipulated semantic plausibility. Eye movements were monitored, while participants read each sentence, and afterwards, participants answered a comprehension question. We also assessed verbal intelligence and working memory in all participants. Results showed dyslexia status interacted with sentence structure and plausibility, such that participants with dyslexia showed significantly more comprehension errors with passive and implausible sentence. With respect to verbal intelligence and working memory, we found that individuals with lower verbal intelligence were overall more likely to make comprehension errors, and individuals with lower working memory showed particular difficulties with passive and implausible sentences. For reading times, we found that individuals with dyslexia were overall slower readers. These findings suggest that (1) individuals with dyslexia do rely on heuristics to a greater extent than do non-dyslexic individuals, and (2) individual differences variables (e.g., verbal intelligence and working memory) are also related to the use of parsing heuristics. For the latter, lower ability individuals tended to be more consistent with heuristic processing (i.e., good-enough representations).
Targeted Therapy for Older Patients with Non-Small Cell Lung Cancer: Systematic Review and Guidelines from the French Society of Geriatric Oncology (SoFOG) and the French-Language Society of Pulmonology (SPLF)/French-Language Oncology Group (GOLF)
Authors: Greillier Laurent , Gauvrit Manon , Paillaud Elena , Girard Nicolas , Montégut Coline , Boulahssass Rabia , Wislez Marie , Pamoukdjian Frédéric , Corre Romain , Cabart Mathilde , Caillet Philippe , Belaroussi Yaniss , Frasca Matthieu , Noize Pernelle , Wang Pascal , Mebarki Soraya , Mathoulin-Pelissier Simone , Couderc Anne-Laure
Published: February 2022

Systematic molecular profiling and targeted therapy (TKI) have changed the face of Non-Small Cell Lung Cancer (NSCLC) treatment. However, there are no specific recommendations to address the prescription of TKI for older patients. A multidisciplinary task force from the French Society of Geriatric Oncology (SoFOG) and the French Society of Pulmonology/Oncology Group (SPLF/GOLF) conducted a systematic review from May 2010 to May 2021. Protocol registered in Prospero under number CRD42021224103. Three key questions were selected for older patients with NSCLC: (1) to whom TKI can be proposed, (2) for whom monotherapy should be favored, and (3) to whom a combination of TKI can be proposed. Among the 534 references isolated, 52 were included for the guidelines. The expert panel analysis concluded: (1) osimertinib 80 mg/day is recommended as a first-line treatment for older patients with the EGFR mutation; (2) full-dose first generation TKI, such as erlotinib or gefitinib, is feasible; (3) ALK and ROS1 rearrangement studies including older patients were too scarce to conclude on any definitive recommendations; and (4) given the actual data, TKI should be prescribed as monotherapy. Malnutrition, functional decline, and the number of comorbidities should be assessed primarily before TKI initiation.
Common Themes and Future Challenges in Understanding Gene Regulatory Network Evolution
Authors: Schember Isabella , Halfon Marc S.
Published: February 2022

A major driving force behind the evolution of species-specific traits and novel structures is alterations in gene regulatory networks (GRNs). Comprehending evolution therefore requires an understanding of the nature of changes in GRN structure and the responsible mechanisms. Here, we review two insect pigmentation GRNs in order to examine common themes in GRN evolution and to reveal some of the challenges associated with investigating changes in GRNs across different evolutionary distances at the molecular level. The pigmentation GRN in Drosophila melanogaster and other drosophilids is a well-defined network for which studies from closely related species illuminate the different ways co-option of regulators can occur. The pigmentation GRN for butterflies of the Heliconius species group is less fully detailed but it is emerging as a useful model for exploring important questions about redundancy and modularity in cis-regulatory systems. Both GRNs serve to highlight the ways in which redeployment of trans-acting factors can lead to GRN rewiring and network co-option. To gain insight into GRN evolution, we discuss the importance of defining GRN architecture at multiple levels both within and between species and of utilizing a range of complementary approaches.
Process Intensification Strategies for Power-to-X Technologies
Authors: Cholewa Thomas , Semmel Malte , Mantei Franz , Güttel Robert , Salem Ouda
Published: February 2022

Sector coupling remains a crucial measure to achieve climate change mitigation targets. Hydrogen and Power-to-X (PtX) products are recognized as major levers to allow the boosting of renewable energy capacities and the consequent use of green electrons in different sectors. In this work, the challenges presented by the PtX processes are addressed and different process intensification (PI) strategies and their potential to overcome these challenges are reviewed for ammonia (NH3), dimethyl ether (DME) and oxymethylene dimethyl ethers (OME) as three exemplary, major PtX products. PI approaches in this context offer on the one hand the maximum utilization of valuable renewable feedstock and on the other hand simpler production processes. For the three discussed processes a compelling strategy for efficient and ultimately maintenance-free chemical synthesis is presented by integrating unit operations to overcome thermodynamic limitations, and in best cases eliminate the recycle loops. The proposed intensification processes offer a significant reduction of energy consumption and provide an interesting perspective for the future development of PtX technologies.
Selective Metal Ion Irradiation Using Bipolar HIPIMS: A New Route to Tailor Film Nanostructure and the Resulting Mechanical Properties
Authors: Fernández-Martínez Iván , Santiago José A. , Mendez Álvaro , Panizo-Laiz Miguel , Diaz-Rodríguez Pablo , Mendizábal Lucía , Díez-Sierra Javier , Zubizarreta Cristina , Monclus Miguel A. , Molina-Aldareguia Jon
Published: February 2022

This manuscript introduces and experimentally demonstrates a novel concept of selective metal ion irradiation by combining bipolar HIPIMS with conventional DC magnetron sputtering operation and simple DC biasing. The addition of the positive pulse to a conventional HIPIMS discharge accelerates the predominantly metal ions created during the negative HIPIMS phase with an energy proportional to the positive pulse amplitude and ionization state. Two distinct metal elements with large difference in atomic mass (Cr and Nb) are used on this work to irradiate a TiAlN matrix which is being deposited by conventional DCMS. The positive acceleration voltages used for both Cr and Nb discharges were varied between 0 to +200 V to analyze the influence of Nb and Cr metal ion irradiation on the mechanical and microstructural properties of TiAlN films. Even though the total metal ion incorporation into the TiAlN matrix for both Cr and Nb is less than 10% at%, strong effects are observed on the resulting film properties. It was observed that use of the lighter metal ion Cr is more beneficial than the heavier metal ion Nb. The Cr bombardment allows a hardness improvement from 7 to 22 GPa as well as a reduced film accumulated stress at the highest positive acceleration voltage. From the XRD measurements it is observed that the Cr atoms are inserted into the TiAlN cubic matrix maintaining its crystalline structure. However, the bombardment with the high-mass metal ion (Nb) promotes the deformation of the cubic TiAlN matrix, resulting in a spinodal decomposition and further degradation of the crystalline structure with the appearance of the hexagonal wurtzite-type Al-rich phase. This is also translated to the resulting film mechanical properties, as hardness rapidly decreases from 25 to 10 GPa and stress increases linearly with the positive voltage acceleration.
Lung Ultrasound in Children with Cystic Fibrosis in Comparison with Chest Computed Tomography: A Feasibility Study
Authors: Ciuca Ioana Mihaiela , Pop Liviu Laurentiu , Dediu Mihaela , Stoicescu Emil Robert , Marc Monica Steluta , Manea Aniko Maria , Manolescu Diana Luminita
Published: February 2022

Background: Cystic fibrosis (CF) lung disease determines the outcome of this condition. For lung evaluation processes, computed tomography (CT) is the gold standard, but also causes irradiation. Lately, lung ultrasound (LUS) has proven to be reliable for the diagnosis of consolidations, atelectasis, and/or bronchiectasis. The aim of our study was to evaluate the value of a newly conceived LUS score by comparing it to the modified Bhalla CT score. A further aim was to evaluate the correlation between the score and the lung clearance index (LCI). Methods: Patients with CF were screened by LUS, followed by a CT scan. Spearman’s test was used for correlations. Results: A total of 98 patients with CF were screened, and 57 were included in the study; their mean age was 11.8 ± 5.5 (mean ± SD) years. The mean LUS score was 5.88 ± 5.4 SD. The LUS CF score had a very strong correlation with the CT score of rs = 0.87 (p = 0.000). LUS showed a good sensibility for detecting atelectasis (Se = 83.7%) and consolidations (Se = 94.4%). A lower Se (77.7%) and Sp (9%) were found for cylindrical bronchiectasis. Conclusion: Our study shows that LUS and the lung CF score are parameters that can be used with a complementary role in the diagnosis and monitoring of CF lung disease in children.
Diagnostic Strategy of Early Stage Pancreatic Cancer via Clinical Predictor Assessment: Clinical Indicators, Risk Factors and Imaging Findings
Authors: Sagami Ryota , Sato Takao , Mizukami Kazuhiro , Motomura Mitsuteru , Okamoto Kazuhisa , Fukuchi Satoshi , Otsuka Yuichiro , Abe Takashi , Ono Hideki , Mori Kei , Wada Kurato , Iwaki Tomoyuki , Nishikiori Hidefumi , Honda Koichi , Amano Yuji , Murakami Kazunari
Published: February 2022

Early detection of pancreatic ductal adenocarcinoma (PDAC) in the general population is difficult due to unknown clinical characteristics. This study was conducted to clarify the factors associated with early stage PDAC. Well-known symptoms and factors associated with PDAC were classified into clinical indicators, risk factors, and imaging findings concomitant with early stage PDAC. To analyze these factors for the detection of patients with early stage PDAC compared to patients without PDAC, we constructed new diagnostic strategies. The factors of 35 patients with early stage PDAC (stage 0 and IA) and 801 patients without PDAC were compared retrospectively. Clinical indicators; presence and number of indicators, elevated pancreatic enzyme level, tumor biomarker level, acute pancreatitis history, risk factors; familial pancreatic cancer, diabetes mellitus, smoking history, imaging findings; presence and number of findings, and main pancreatic duct dilation were significant factors for early stage PDAC detection. A new screening strategy to select patients who should be examined by imaging modalities from evaluating clinical indicators and risk factors and approaching a definitive diagnosis by evaluating imaging findings had a relatively high sensitivity, specificity, and areas under the curve of 80.0%, 80.8%, and 0.80, respectively. Diagnosis based on the new category and strategy may be reasonable for early stage PDAC detection.
Peripartum Cardiomyopathy: Diagnostic and Prognostic Value of Cardiac Magnetic Resonance in the Acute Stage
Authors: Isaak Alexander , Ayub Tiyasha H. , Merz Waltraut M. , Faron Anton , Endler Christoph , Sprinkart Alois M. , Pieper Claus C. , Kuetting Daniel , Dabir Darius , Attenberger Ulrike , Zimmer Sebastian , Becher Ulrich M. , Luetkens Julian A.
Published: February 2022

This study aimed to evaluate the diagnostic and prognostic value of cardiac magnetic resonance in acute peripartum cardiomyopathy (PPCM). A total of 17 patients with PPCM in the acute stage and 15 healthy controls were retrospectively analyzed regarding myocardial function, edema, late gadolinium enhancement (LGE), and T1 and T2 mappings (T1, T2). Echocardiographic follow-ups were performed. Functional recovery was defined as a left ventricular ejection fraction (LVEF) of ≥50%. Patients with PPCM displayed biventricular dysfunction with reduced myocardial strain parameters and left ventricular and atrial dilatation, as well as diffuse myocardial edema (T2 signal intensity ratio: 2.10 ± 0.34 vs. 1.58 ± 0.21, p < 0.001; T1: 1070 ± 51 ms vs. 980 ± 28 ms, p = 0.001; T2: 63 ± 5 ms vs. 53 ± 2 ms, p < 0.001). Visual myocardial edema was present in 10 patients (59%). LGE was positive in 2 patients (12%). A total of 13 patients (76%) showed full LVEF recovery. The absence of visual myocardial edema and impairment of strain parameters were associated with delayed LVEF recovery. Multivariable Cox regression analysis revealed global longitudinal strain as an independent prognostic factor for LVEF recovery. In conclusion, biventricular systolic dysfunction with diffuse myocardial edema seems to be present in acute PPCM. Myocardial edema and strain may have prognostic value for LVEF recovery.
Root Resorptions on Adjacent Teeth Associated with Impacted Maxillary Canines
Authors: Simić Sanja , Nikolić Predrag , Stanišić Zindović Jelena , Jovanović Radovan , Stošović Kalezić Ivana , Djordjević Aleksandar , Popov Vesna
Published: February 2022

Aim: Through the use of CBCT images, many unidentified features of impacted canines can be easily resolved. The potential collision of impacted maxillary canines and adjacent teeth could lead to root resorption (RR). The aim of this study is to examine the prevalence, location and severity of RR on adjacent teeth caused by impacted maxillary canines and the association between the adjacent teeth and the features of maxillary impacted canines on CBCT. Methods: This study examined 89 subjects with 108 maxillary impacted canines, having had no previous orthodontic treatment (mean age: 18.3 ± 4.1 years). The following impacted-canine-related parameters were analyzed on the CBCT images: location; RR levels on adjacent teeth; occlusal line and midline distances of impacted canines; and the angulations of impacted canines to the midline, lateral incisor and occlusal line. Logistic regression was used to evaluate the association between RR and the measured parameters on CBCT. Results: In this study, we found that the majority of our patients with impacted maxillary canines were female (62.5%). Of the total 108 maxillary impacted canines, 60.2% resorbed the adjacent teeth of the affected quadrants. Lateral incisors were the most affected (34.3%). The mean age of subjects with RR was 16.7 ± 3.5 years. The frequency of RR was statistically significantly higher in female subjects (40.4%). Slight RR was the most frequent (30.5%) and the highest incidence noted at the apical third of the root (29.6%). Regarding the impacted maxillary canine angulation to the midline and adjacent tooth, higher values of angulation caused severe forms of RR (p < 0.05). Conclusion: The sensitivity of CBCT allows for the accurate diagnosis of the location and the degree of RR, alongside the angulation and distance of impacted canines to adjacent teeth. The association between the linear and angular features of the impacted maxillary canines and RR was confirmed.
Social Capital, Intellectual Capital, and Audit Fee: Conflicting Evidence from Iran
Authors: Tarighi Hossein , Salehi Mahdi , Moradi Mahdi , Zimon Grzegorz
Published: February 2022

In the current study, we investigate the impacts of social capital (SC) and intellectual capital (IC) on audit fees among the companies listed on the Tehran Stock Exchange (TSE). Since the criteria for the norms and the networks are extremely correlated, we used a principal component analysis (PCA) to construct an index of social capital for each province between 2011 and 2016. The Pulic model is also used as a proxy for measuring value added intellectual capital (VAIC). The ordinary least squares (OLS) regression is employed in this study to test our research hypotheses as well. According to the research literature, on the one hand, investors and lenders can be more confident in the financial reporting honesty of the firms headquartered in areas with high social capital; on the other hand, auditors judge the trustworthiness of their clients based on where the firm is headquartered. Inconsistent with the prior studies, our findings show that companies headquartered in provinces with high social capital pay higher audit fees. Given that Iranian firms are under heavy financial pressure due to economic sanctions, those companies located in areas with higher social capital likely have abused the high level of trust that auditors and other groups in the market have in them and participated in earnings manipulation to mask their weak financial performance. Among the various components of IC, we found strong evidence that employed capital efficiency (ECE) and audit costs correlated positively. In short, this paper sheds light on the fact that severe financial pressures on managers may sometimes lead them to take advantage of the dark side of social capital and intellectual capital when preparing financial reports.
Antioxidant in Food Safety and Sustainability
Authors: Złotek Urszula , Jakubczyk Anna , Gawlik-Dziki Urszula
Published: February 2022

Nowadays, safety and a positive effect on health are desirable features of food in addition to its nutritional value [...]
Transport of Veterinary Antibiotics in Farmland Soil: Effects of Dissolved Organic Matter
Authors: Gbadegesin Lanre Anthony , Tang Xiangyu , Liu Chen , Cheng Jianhua
Published: February 2022

The application of manure as a fertiliser to farmland is regarded as a major source of veterinary antibiotic (VA) contamination in the environment. The frequent detection of such emerging contaminants and their potential adverse impacts on the ecosystem and human health have provoked increasing concern for VA transport and fate. Extrinsic dissolved organic matter (DOM) may be introduced into farmland soil along with Vas, and thus exert significant effects on the transport of VAs via hydrological processes upon rainfall. The leaching of VAs can be either enhanced or reduced by DOM, depending on the nature, mobility, and interactions of VAs with DOM of different origins. From the aspect of the diversity and reactivity of DOM, the state-of-the-art knowledge of DOM−VA interactions and their resulting effects on the sorption−desorption and leaching of VAs in farmland soil was reviewed. Spectroscopic techniques for examining the extent of binding and reactive components of DOM with VAs are summarized and their usefulness is highlighted. Models for simulating VA transport under the effects of DOM were also reviewed. It is suggested that distinct impacts of DOM of various organic fertiliser/amendment origins should be considered for predicting the transport of VAs in farmland soil.
Impacts of COVID-19 on Air Quality through Traffic Reduction
Authors: Hwang Hyemin , Lee Jae Young
Published: February 2022

In 2020, the first case of COVID-19 was confirmed in Korea, and social distancing was implemented to prevent its spread. This reduced the movement of people, and changes in air quality were expected owing to reduced emissions. In the present paper, the impact of traffic volume change caused by COVID-19 on air quality in Seoul, Korea, is examined. Two regression analyses were performed using the generalized additive model (GAM), assuming a Gaussian distribution; the relationships between (1) the number of confirmed COVID-19 cases in 2020–2021 and the rate of change in the traffic volume in Seoul, and (2) the traffic volume and the rate of change in the air quality in Seoul from 2016 to 2019 were analyzed. The regression results show that traffic decreased by 0.00431% per COVID-19 case; when traffic fell by 1%, the PM10, PM2.5, CO, NO2, O3, and SO2 concentrations fell by 0.48%, 0.94%, 0.39%, 0.74%, 0.16%, and −0.01%, respectively. This mechanism accounts for air quality improvements in PM10, PM2.5, CO, NO2, and O3 in Seoul during 2020–2021. From these results, the majority of the reduction in pollutant concentrations in 2020–2021 appears to be the result of a long-term declining trend rather than COVID-19.
Working with Disaster-Affected Communities to Envision Healthier Futures: A Trauma-Informed Approach to Post-Disaster Recovery Planning
Authors: Rosenberg Heather , Errett Nicole A. , Eisenman David P.
Published: February 2022

Disasters are becoming increasingly common and devastating, requiring extensive reconstruction and recovery efforts. At the same time, the level of available resources and the need to rebuild can present opportunities for more resilient land use and infrastructure, and to build healthier, more equitable and sustainable communities. However, disaster-affected individuals may experience trauma and mental health impacts that impede their ability to engage in long-range recovery planning. It is essential to consider and address community trauma when engaging with disaster-affected communities and in developing plans for recovery. Planners and engineers from outside the community (including public, private and non-profit practitioners) are often brought in to support long-term recovery. Most of these practitioners (particularly those focused on longer-range recovery) have no training in how disasters can affect mental health or what this could mean for their interactions with individuals or communities. In order to acknowledge and address disaster trauma in community recovery and redevelopment, we propose a trauma-informed approach which aims to provide practitioners supporting post-disaster community recovery planning guidance, in order to: avoid the causation of harm by re-traumatizing communities; better understand community needs; make sense of observed behaviors and avoid potential roadblocks; avoid becoming traumatized themselves; and facilitate community healing.
‘Physio-EndEA’ Study: A Randomized, Parallel-Group Controlled Trial to Evaluate the Effect of a Supervised and Adapted Therapeutic Exercise Program to Improve Quality of Life in Symptomatic Women Diagnosed with Endometriosis
Authors: Salinas-Asensio María del Mar , Ocón-Hernández Olga , Mundo-López Antonio , Fernández-Lao Carolina , Peinado Francisco M. , Padilla-Vinuesa Carmen , Álvarez-Salvago Francisco , Postigo-Martín Paula , Lozano-Lozano Mario , Lara-Ramos Ana , Arroyo-Morales Manuel , Cantarero-Villanueva Irene , Artacho-Cordón Francisco
Published: February 2022

Aim: The ‘Physio-EndEA’ study aims to explore the potential benefits of a therapeutic exercise program (focused on lumbopelvic stabilization and tolerance to exertion) on the health-related quality of life (HRQoL) of symptomatic endometriosis women. Design: The present study will use a parallel-group randomized controlled trial design. Methods: A total of 22 symptomatic endometriosis women will be randomized 1:1 to the Physio-EndEA or usual care groups. The ‘Physio-EndEA’ program will consist of a one-week lumbopelvic stabilization learning phase followed by an eight-week phase of stretching, aerobic and resistance exercises focused on the lumbopelvic area that will be sequentially instructed and supervised by a trained physiotherapist (with volume and intensity progression) and adapted daily to the potential of each participant. The primary outcome measure is HRQoL. The secondary outcome measures included clinician-reported outcomes (pressure pain thresholds, muscle thickness and strength, flexibility, body balance and cardiorespiratory fitness) and patient-reported outcomes (pain intensity, physical fitness, chronic fatigue, sexual function, gastrointestinal function and sleep quality). Discussion: Findings of this study will help to identify cost-effective non-pharmacological options (such as this exercise-based intervention) that may contribute to the improvement of HRQoL in symptomatic endometriosis women.
Spatiotemporal Graph Convolutional Network for Multi-Scale Traffic Forecasting
Authors: Wang Yi , Jing Changfeng
Published: February 2022

Benefiting from the rapid development of geospatial big data-related technologies, intelligent transportation systems (ITS) have become a part of people’s daily life. Traffic volume forecasting is one of the indispensable tasks in ITS. The spatiotemporal graph neural network has attracted attention from academic and business domains for its powerful spatiotemporal pattern capturing capability. However, the existing work focused on the overall traffic network instead of traffic nodes, and the latter can be useful in learning different patterns among nodes. Moreover, there are few works that captured fine-grained node-specific spatiotemporal feature extraction at multiple scales at the same time. To unfold the node pattern, a node embedding parameter was designed to adaptively learn nodes patterns in adjacency matrix and graph convolution layer. To address this multi-scale problem, we adopted the idea of Res2Net and designed a hierarchical temporal attention layer and hierarchical adaptive graph convolution layer. Based on the above methods, a novel model, called Temporal Residual II Graph Convolutional Network (Tres2GCN), was proposed to capture not only multi-scale spatiotemporal but also fine-grained features. Tres2GCN was validated by comparing it with 10 baseline methods using two public traffic volume datasets. The results show that our model performs good accuracy, outperforming existing methods by up to 9.4%.
Erythema Migrans-like COVID Vaccine Arm: A Literature Review
Authors: Fasano Gaia , Bennardo Luigi , Ruffolo Silvana , Passante Maria , Ambrosio Azzurra Gaia , Napolitano Maddalena , Provenzano Eugenio , Nisticò Steven Paul , Patruno Cataldo
Published: February 2022

COVID Vaccine Arm (CVA) is an adverse drug reaction from mRNA vaccine for SARS-CoV-2. CVA is characterized by erythema and edema on the vaccination site (usually deltoid area) that appears from 5 to 10 days after vaccination and is sometimes associated with itching or pain. The exact etiology of CVA is still unclear, but delayed hypersensitivity against an excipient seems to play an essential role in the pathogenesis of the disease. This work performs a systematic literature review on CVA using three different databases containing articles published until 10 November 2021. The literature review includes eight papers reporting single cases or case series of CVA. Moreover, it also addresses, other cutaneous reactions following COVID 19 vaccinations as well as possible differential diagnosis. CVA migrans-like erythema is characterized by a ring-shaped rash in the injection area, which appears some days after the injection and disappears in about 10 days. This reaction may appear more rapidly in subsequent doses.
3-Isobutyl-5,5,7-tris(3-methylbut-2-en-1-yl)-1-phenyl-1,7-dihydro-4H-indazole-4,6(5H)-dione
Authors: Nascimento José Edmilson Ribeiro do , Hartwig Daniela , Jacob Raquel Guimarães , Silva Márcio Santos
Published: February 2022

Here we describe the functionalization of lupulone natural compound in obtaining 3-isobutyl-5,5,7-tris(3-methylbut-2-en-1-yl)-1-phenyl-1,7-dihydro-4H-indazole-4,6(5H)-dione. The lupulone-H-indazole derivative was prepared with 75% yield through the reaction between lupulone and phenyl-hydrazine employing SiO2/ZnCl2 (30% m/m) as a support solid in a solvent-free condition. Based on the possibilities of products, a complete NMR structural characterization of this lupulone-H-indazole was performed by 1H, 13C{1H}, COSY, HSQC and HMBC NMR experiments, showing an important contribution in producing the first results related to lupulone reactivity.
Magnesium-Based Alloys Used in Orthopedic Surgery
Authors: Antoniac Iulian , Miculescu Marian , Mănescu (Păltânea) Veronica , Stere Alexandru , Quan Pham Hong , Păltânea Gheorghe , Robu Alina , Earar Kamel
Published: February 2022

Magnesium (Mg)-based alloys have become an important category of materials that is attracting more and more attention due to their high potential use as orthopedic temporary implants. These alloys are a viable alternative to nondegradable metals implants in orthopedics. In this paper, a detailed overview covering alloy development and manufacturing techniques is described. Further, important attributes for Mg-based alloys involved in orthopedic implants fabrication, physiological and toxicological effects of each alloying element, mechanical properties, osteogenesis, and angiogenesis of Mg are presented. A section detailing the main biocompatible Mg-based alloys, with examples of mechanical properties, degradation behavior, and cytotoxicity tests related to in vitro experiments, is also provided. Special attention is given to animal testing, and the clinical translation is also reviewed, focusing on the main clinical cases that were conducted under human use approval.
Polynomial Multiple Regression Analysis of the Lubrication Effectiveness of Deep Drawing Quality Steel Sheets by Eco-Friendly Vegetable Oils
Authors: Trzepieciński Tomasz
Published: February 2022

Ensuring adequate lubrication is a key task in the sheet metal forming process. The replacement of commonly used synthetic lubricants in metal forming operations by eco-friendly equivalents is a way to introduce sustainable manufacturing. In this paper, six kinds of vegetable oils (linseed, palm, sunflower, cotton seed, soybean and coconut) were used to study the effect of lubricant type on the value of the coefficient of friction (COF) in sheet metal forming. The strip drawing test was used to simulate the friction conditions. The tests were carried out for various lubrication conditions and pressures. The polynomial quadratic regression model was used to determine the relationship between the input variables (test conditions) and the COF. For the range of the nominal pressures considered (2–12 MPa), the following oils provided the highest lubrication efficiency: palm, sunflower and cotton seed. These oils decreased the value of the COF by about 11–16% depending on the nominal pressure. Linseed oil had the most unfavourable properties, reducing the COF by about 7–12%. For the whole range of pressures considered, the increase in the viscosity of the oil caused a reduction in the value of the COF. The effect of oil density on the COF value was similar. The most unfavourable friction conditions occurred when there was low density and low viscosity of the oil at the same time.
Modelling and Analysis of the Effect of EDM-Drilling Parameters on the Machining Performance of Inconel 718 Using the RSM and ANNs Methods
Authors: Machno Magdalena , Matras Andrzej , Szkoda Maciej
Published: February 2022

Electrical Discharge Machining (EDM) is one of the most efficient processes to produce high-ratio micro holes in difficult-to-cut materials in the Inconel 718 superalloy. It is important to apply a statistical technique that guarantees a high fit between the predicted values and those measured during analysis of test results. It was especially important to check which method gives a better fit of the calculated result values in case they were relatively small and/or close to each other. This study developed models with the use of the response surface methodology (RSM) and artificial neural networks (ANNs). The aim of the study was comparison between two models (RSM and ANNs) and to check which model gives a better data fit for relatively similar values in individual tests. In all cases, the neural network models provided a better value fit. This is due to the fact that neural networks use better fitted functions than in the case of the RSM method using quadratic fitting. This comparison included the aspect ratio hole and the thickness side gap data, the values of which for individual tests were very similar. The paper reports an analysis of the impact of parameter variables on the analyzed factors. Higher values of current amplitude, pulse time length, and rotational speed of the working electrode resulted in higher drilling speed (above 15 µm/s, lower linear tool wear (below 15%), higher aspect ratio hole (above 26), lower hole conicity (below 0.005), and lower side gap thickness at the hole inlet (below 100 µm).
Roughness and SEM Analysis of Manual and Ultrasonic Instrumentation over Different Crown Materials for Dental Implants Restorations
Authors: Baldi Domenico , Colombo Jacopo , Gavoglio Paola , De Giorgis Luisa , Motta Franco , Lugas Andrea , Lertora Enrico , Schierano Gianmario
Published: February 2022

The use of new prosthetic materials makes it necessary to establish adequate hygienic protocols. It was decided to make prosthetic crowns from four different materials: composite, lithium disilicate, metal ceramic, and zirconium, and to evaluate the effects on the surfaces of four different instruments through SEM and roughness analysis: manual steel curette, manual titanium curette, ultrasonic steel insert, and ultrasonic peek insert. Forty crowns were made, ten of each type of material. For each material, five crowns were manually instrumented with steel inserts (curette 11-12, PDT, Missoula, MT, USA) and titanium (Wingrove 3-4, PDT, Missoula, MT, USA) on the lingual and buccal surfaces, respectively, and the other five crowns were instrumented with an ultrasonic peek insert (ICS-IC1, Mectron, Carasco, Italy) on the buccal surface and steel (PS, EMS, Nyon, Switzerland) on the lingual surface. At this point, surface roughness analysis was carried out. The data were analyzed with a Kolmogorov–Smirnov test. Therefore, it was decided to conduct two analyses with a Kruskal–Wallis test and Bonferroni post hoc test. Then, the instrumented crowns were analyzed by SEM. The analysis of the data shows that the highest average roughness was within the composite group, while the best material appeared to be disilicate. Significant differences existed between the groups, between the materials, and between the different instruments (p-value < 0.05). In the qualitative analysis carried out by SEM, the classic steel insert eliminated the residues of golden finishing. The peek insert created alterations on all tested surfaces. The steel curette did not create particular problems, with the exception of zirconium, where it was possible to observe some scratch lines. Instrumentation with the titanium curette created deeper incisions than the steel curette in the composite and disilicate. The best results came from the ultrasonic steel insert, while the best material appeared to be disilicate.
Dissolution of Zinc Oxide Nanoparticles in the Presence of Slow Acid Generators
Authors: Kürsteiner Ronny , Ritter Maximilian , Ding Yong , Panzarasa Guido
Published: February 2022

We describe a preliminary investigation of the dissolution dynamics of zinc oxide nanoparticles in the presence of cyclic esters (δ-gluconolactone and propanesultone) as slow acid generators. The particles dissolution is monitored by means of turbidimetry and correlated with the evolution of pH over time. The results could be of interest for the design of chemically programmable colloidal systems.
Application of Graphene-Related Materials in Organic Solar Cells
Authors: Velasco Davoise Lara , Díez-Pascual Ana M. , Peña Capilla Rafael
Published: February 2022

Graphene-related materials (GRMs) such as graphene quantum dots (GQDs), graphene oxide (GO), reduced graphene oxide (rGO), graphene nanoribbons (GNRs), and so forth have recently emerged as photovoltaic (PV) materials due to their nanodimensional structure and outstanding properties such as high electrical and thermal conductivity, large specific surface, and unique combination of mechanical strength and flexibility. They can be a crucial part of transparent electrodes, hole/electron transport materials, and active layers in organic solar cells (OSCs). Besides their role in charge extraction and transport, GRMs act as device protectors against environmental degradation through their compact bidimensional structure and offer good durability. This review briefly presents the synthesis methods of GRMs and describes the current progress in GRM-based OSCs. PV parameters (short circuit current, open circuit voltage, power conversion efficiency, and fill factor) are summarized and comparatively discussed for the different structures. The efficiency recently surpassed 15% for an OSC incorporating polymer-modified graphene as a transparent electrode. The long-term stability of OSCs incorporating GRMs is also discussed. Finally, conclusions and the outlook for future investigation into GRM-based devices for PVs are presented.
A Novel Mathematical Approach to Model Multi-Agent-Based Main Grid and Microgrid Networks for Complete System Analysis
Authors: Hamza Ameer , Rizvi Syed Tahir Hussain , Safder Muhammad Umair , Asif Haleema
Published: February 2022

Penetration of renewable energy resources in modern power systems has increased rapidly. The integration of different renewable and nonrenewable resources for the purpose of electricity generation is referred to as Distributed Generation (DG) units. The penetration of DG units gave birth to the concept of power microgrid. Power inverters play a major role in the integration of DGs in the power system. Control and stability analysis of microgrids in power systems is a challenging task for the control community. Dynamic microgrid modeling demands knowledge of fundamental engineering laws to detailed theoretical analysis. To model the dynamic behavior of the power microgrid, a basic understanding of the power converter operation modes and their control schemes is necessary. The main microgrid modeling components are power converters, power lines, transformers, protection systems, load, and faults. In this paper, preliminary concepts of power systems along with graph theoretic approach are used to develop the model of the microgrid and main grid networks. A mathematical model of a power microgrid in islanded mode, as well as the grid-connected mode, is developed and comprises of generation sources, power inverter interface, protection mechanism, load, faults, and transmission lines. The developed mathematical model can be used to address the stability issues as well as resilience in the power networks for complete system analysis. To validate the mathematical model, a renewable energy-based main grid and microgrid model is simulated. The graphical result of simulated model presents the generation and load curves.
The Expression and Prognostic Value of Cancer Stem Cell Markers, NRF2, and Its Target Genes in TAE/TACE-Treated Hepatocellular Carcinoma
Authors: Tseeleesuren Duurenjargal , Hsiao Hui-Hua , Kant Rajni , Huang Yu-Chuen , Tu Hung-Pin , Lai Chih-Chung , Huang Shiu-Feng , Yen Chia-Hung
Published: February 2022

Background and Objectives: Activation of NRF2, a key transcription factor of cytoprotectant against oxidative stress, and its target genes are associated with aggressive tumor progression, metastasis and poor survival. In addition, NRF2 signaling mediates cancer stem cell (CSC)-like properties in hepatocellular carcinoma (HCC) cells. Moreover, CSCs have been associated with HCC onset and unfavorable prognosis. Transcatheter arterial embolization (TAE) and/or transcatheter arterial chemoembolization (TACE), which attempt to restrict blood supply to diminish tumor growth, can create a hypoxic environment. However, its effect on NRF2 signaling and CSC marker CD133 in the context of prognosis of HCCs have not been investigated. Therefore, we studied the possible role of the expressions of NRF2, its target genes and CSC markers CD133 and EpCAM on the survival of HCC patients after TAE/TACE. Materials and Methods: RT-qPCR was performed with 120 tumor (T) and adjacent tumor (N) tissue pairs. Expression of a single marker or combination was assessed for associations with survival of HCC patients after TAE/TACE. Results: The result of multivariate Cox regression showed that vascular invasion (HR, 1.821; p = 0.015), metastasis (HR, 2.033; p = 0.049) and CD133 overexpression (HR, 2.013; p = 0.006) were associated with poor survival. In a Kaplan–Meier survival analysis, patients with high expression of CD133 had shorter overall survival (OS) than those with low expression of CD133 in post-TAE/TACE HCC (p < 0.001). In contrast, neither NRF2 nor components of its signaling pathway correlated with survival. Combination marker analysis showed that co-expression of NQO1 and CD133 was associated with poor outcome. Conclusions: This study suggests that analyzing the expression status of CD133 alone and co-expression of NQO1 and CD133 may have additional value in predicting the outcome of TAE/TACE-treated HCC patients.
Impact of Insurance Benefits and Education on Point-of-Care Ultrasound Use in a Single Emergency Department: An Interrupted Time Series Analysis
Authors: Kang Soo-Yeon , Park Sookyung , Jo Ik-Joon , Jeon Kyeongman , Kim Seonwoo , Lee Guntak , Park Jong-Eun , Kim Taerim , Lee Se-Uk , Hwang Sung-Yeon , Cha Won-Chul , Shin Tae-Gun , Yoon Hee
Published: February 2022

Background and Objectives: Point-of-care ultrasound (POCUS) is a useful tool that helps clinicians properly treat patients in emergency department (ED). This study aimed to evaluate the impact of specific interventions on the use of POCUS in the ED. Materials and Methods: This retrospective study used an interrupted time series analysis to assess how interventions changed the use of POCUS in the emergency department of a tertiary medical institute in South Korea from October 2016 to February 2021. We chose two main interventions—expansion of benefit coverage of the National Health Insurance (NHI) for emergency ultrasound (EUS) and annual ultrasound educational workshops. The primary variable was the EUS rate, defined as the number of EUS scans per 1000 eligible patients per month. We compared the level and slope of EUS rates before and after interventions. Results: A total of 5188 scanned records were included. Before interventions, the EUS rate had increased gradually. After interventions, except for the first workshop, the EUS rate immediately increased significantly (p < 0.05). The difference in the EUS rate according to the expansion of the NHI was estimated to be the largest (p < 0.001). However, the change in slope significantly decreased after the third workshop during the coronavirus disease 2019 pandemic (p = 0.004). The EUS rate increased significantly in the presence of physicians participating in intensive POCUS training (p < 0.001). Conclusion: This study found that expansion of insurance coverage for EUS and ultrasound education led to a significant and immediate increase in the use of POCUS, suggesting that POCUS use can be increased by improving education and insurance benefits.