bluuebunny/crossref_metadata_2025 huggingface dataset:
MATERIAL DIDÁTICO DE ENSINO DO HEBRAICO: ALGUMAS CONSIDERAÇÕES SOBRE ELEMENTOS NACIONAIS E RELIGIOSOS
Authors: Puh Milan , Ankava Matan
Published: September 2022

Neste trabalho estudamos os discursos nacionais e religiosos encontrados em material didático de ensino de hebraico, produzido por uma escola paulistana judaica. Considerando a influência da ideologia sionista e das fontes judaicas na formação do hebraico moderno, entendemos que a relação entre as duas abordagens discursivas representa um projeto pedagógico e ideológico específico. Assim, o objetivo principal é compreender de que modo o religioso e o nacional são incorporados no ensino do idioma em comunidades fora de Israel.
Teatro em Tempos do Holocausto: Espaço de Resistência Contra a Intolerância
Authors: Marko Leslie
Published: September 2022

Esta comunicação apresenta alguns resultados da pesquisa de doutorado sobre o movimento de resistência sustentado por artistas, atores, diretores, autores e espectadores durante o período em que o nazifascismo dominou grande parte da Europa (1939-1945). A relevância deste estudo está em analisar a atuação de um artista, Sami Feder, que buscou o exercício ético do acolhimento coletivo e da cidadania, por meio da arte. Ações intervencionistas como estas propagaram-se pelas cidades ocupadas, guetos e campos de concentração enquanto reação ao processo de desumanização sustentado pelo Estado nacional-socialista e países colaboracionistas
Chufshat Kaitz e o Silêncio da Mulher
Authors: Szlak Bruno José
Published: September 2022

O texto analisa o filme Chufshat Kaitz (My Father, my Lord) de David Volach, produção israelense de 2007. Procura relacionar no universo fílmico e no desenrolar do roteiro especialmente a questão do silêncio feminino, socialmente construído dentro de uma sociedade paternalista. Analisa ainda questões ligadas à Lei Judaica que culminam com episódios de descrença e perda.
A Mensagem dos Profetas
Authors: Silva Célio
Published: September 2022

A profecia não foi um fenômeno próprio do Antigo Israel, mas do Oriente Médio a que ele pertenceu. Encontramos relatos e expressões proféticas tanto no Egito quanto na Mesopotâmia (Mari, Assíria) e na Síria-Palestina. Os profetas de Israel, inseridos nesse contexto, falaram como mediadores de Yahweh para a realidade em que viveram e, por isso, abordaram-na nos diversos aspectos que a compunham, dentre os quais destacaremos três: o social, o político e o religioso.
Números na Bíblia Hebraica: A Origem dos Algarismos
Authors: Hubner Manu Marcus
Published: September 2022

A importância dos números é gigantesca. É possível que os números tenham sido inventados para resolver problemas práticos da humanidade, como a contagem de rebanhos ou grãos, dos dias, meses e anos, entre muitos outros usos. Milhares de anos se passaram desde o início destas contagens até a adoção dos símbolos gráficos utilizados convencionalmente como algarismos, um processo lento e que ainda apresenta divergências entre diversas sociedades humanas. Mais do que simples ferramentas de contagem ou aritmética, os números são necessários e indispensáveis ao desenvolvimento de qualquer sociedade humana. Além de quantificar tudo o que se encontra ao redor do homem, os números também possuem significados simbólicos, muitas vezes além da lógica humana. Na Bíblia Hebraica, os números são freqüentes e apresentam diversos significados, muitas vezes simbólicos. A Bíblia Hebraica também apresenta diversos cálculos matemáticos e uma numerologia chamada guemátria, que possibilita a análise bíblica através de interpretações e correlações entre valores numéricos de palavras ou frases.
Normatividades e Perversões no Código Deuteronômico
Authors: Silva Fernando Cândido da
Published: September 2022

O artigo avalia as prescrições normativas de três perícopes do Código Deuteronômico (13,2-6; 21,18-21; 22,13-21), correlacionando-as sob o contexto da Judá do século VII a.C. Ao salientar o tom retórico dos textos, o artigo procura dar voz aos sujeitos sociais que seguiam versões diferentes (per/vertidos) do projeto de unificação josiânica. Palavras-chave: normatividades; perversões; Código Deuteronômico; retórica; subordinação.
Caim de Saramago e a Lenda do Judeu Errante: Reflexões Sobre a Construção de Um Mito
Authors: Leal Eliane Alves
Published: September 2022

Resultado das primeiras análises sobre a obra Caim, escrita por José Saramago (2009), este trabalho empenha-se em compreender, historicamente, a construção do mito Caim na longa duração e sua proximidade com a lenda do Judeu Errante. Desse modo, a paródia, em relação à escrita sagrada dos cristãos, bem como a ironia se fazem presentes em cada cena, o que é valioso para compreender o modo como Saramago reconstrói seu protagonista. Assim, esta pesquisa valorizará as relações entre História e Literatura.
A ASSIMILAÇÃO EM PASTORAL AMERICANA, DE PHILIP ROTH
Authors: Sinay Isadora Goldberg
Published: September 2022

O artigo busca analisar a questão da assimilação no romance "Pastoral Americana", de Philip Roth. Ganhador do prêmio Pulitzer em 1997, o livro conta a história de Sueco Levov, um judeu assimilado cuja filha comete atos terroristas nos anos 60. A partir desse foco familiar, o autor explora a adaptação e rejeição do sonho americano por judeus de diversas gerações.
O Renascimento da Língua Hebraica e sua Continuidade na Diáspora
Authors: Szuchman Esther
Published: September 2022

O conjunto de processos que ocorre atualmente em diversas esferas da vida tornou o mundo no qual vivemos uma “aldeia global”. Distâncias geográficas, antes consideradas intransponíveis, foram superadas por meio da alta tecnologia, possibilitando uma maior aproximação entre diversos grupos culturais. Roupas, alimentos, filmes e composições musicais são universalmente familiares. Essas transformações produziram reflexos em diversas áreas do conhecimento e, sobretudo, na linguagem. Após ter sido usada por mais de 1700 anos, essencialmente como veículo de expressão literária escrita e de orações, a língua hebraica foi revitalizada e integrada de forma viva e em uso com o restabelecimento do Estado judeu. Como observa justamente Agnon: com o passar do tempo, e, sobretudo, durante o longo exílio alguns sábios já misturavam em seus livros temas sacros e laicos “cessaram de aproveitar- se da santidade das letras e escreveram sobre temas variados.” Os livros deixaram de debater exclusivamente normas, leis e comentários religiosos e éticos e deixaram de estar prenhes de louvores a Deus e de lamentos pelas aflições de Israel. Essas obras estavam agora dedicadas também à poesia, contos, dramas ou simplesmente dedicados ao gozo mundano. Vale lembrar, no entanto, que a “língua sagrada hebraica” tornou-se “secular laica” já na Europa, com o movimento de Emancipação da Europa do Século XIX (ilustração judaica), antes mesmo do movimento sionista (cuja representação simbólica era torná-la uma língua viva e em uso). Atualmente, o hebraico é a língua oficial e nacional do Estado de Israel, falada e escrita em todas as áreas do conhecimento: na filosofia, na imprensa, na tecnologia e na literatura. As transformações sofridas pela língua em Israel, desde sua adoção como língua nacional e oficial do Estado, absorvendo influencias inicialmente do Iídiche, Russo e do Inglês e, sendo esta ultima “língua franca” e hegemônica no mundo atual, tem contribuído de forma singular no ensino da língua hebraica como língua adicional na Diáspora.
Poesia Hebraica Bíblica: A Relação entre Forma e Conteúdo em Juízes 4 e 5
Authors: Nunes Edson, Jr. Magalhães
Published: September 2022

A prosa e a poesia da Bíblia Hebraica guardam similaridades e diferenças, mas nem sempre delimitar a forma de ambas é fácil. Além disso, se a forma guarda relação com o conteúdo, pressupõe-se que ao contar a mesma história de formas diferentes (prosa e poesia) indicará um propósito distinto também. O artigo é uma análise da relação entre forma e conteúdo em Juízes 4 e 5 a partir das diferenças e similaridades entre prosa e poesia.
A Cidade Santa: A Representação de Jerusalém em Flávio Josefo
Authors: Pena Joabson Xavier
Published: September 2022

Dentre os muitos pontos da identidade judaica enfocado por Josefo em suas obras, uma em particular, se relaciona com Jerusalém. Membro do grupo sacerdotal e um hierosolomita por nascimento, este historiador justifica a presença dessa cidade como um símbolo unificador dos judeus em todo mundo. Partindo de uma ótica historiográfica, este espectador privilegiado faz uma representação da cidade, manifesto em palavras e em figurações mentais imagéticas. O artigo que se segue elege alguns episódios da história de Jerusalém e que são considerados singulares para o entendimento desse centro urbano para Josefo.
Association of Lifestyle With Incidence of Heart Failure According to Metabolic and Genetic Risk Status: A Population-Based Prospective Study
Authors: Zhu Zhengbao , Li Fu-Rong , Jia Yiming , Li Yang , Guo Daoxia , Chen Jingsi , Tian Haili , Yang Jing , Yang Huan-Huan , Chen Li-Hua , Zhang Kaixin , Yang Pinni , Sun Lulu , Shi Mengyao , Zhang Yonghong , Qin Li-Qiang , Chen Guo-Chong
Published: September 2022

Background:

Whether lifestyle factors are similarly associated with risk of heart failure (HF) for individuals with different metabolic or genetic risk status remains unclear.

Methods:

We included 464 483 participants from UK Biobank who were free of major cardiovascular disease or HF during baseline recruitment. Healthy lifestyle factors included avoidance of smoking, no obesity, regular physical activity, and healthy diet. Lifestyle was categorized as favorable (3 or 4 healthy lifestyle factors), intermediate (2 healthy lifestyle factors), and unfavorable (0 or 1 healthy lifestyle factor) lifestyles. Metabolic status was defined by the presence of hypertension, high total cholesterol, or diabetes at baseline. A weighted genetic risk score was created based on 12 single-nucleotide polymorphisms associated with HF.

Results:

Compared with favorable lifestyle, the multivariable-adjusted hazard ratios of HF were 1.79 (95% CI, 1.68–1.90) and 2.90 (95% CI, 2.70–3.11) for intermediate lifestyle and unfavorable lifestyle, respectively (
P
trend
<0.0001). This association was largely consistent regardless of the presence of any single metabolic risk factor or the number of metabolic risk factors (
P
interaction
≥0.21). The association was also similar across different genetic risk categories (
P
interaction
=0.92). In a joint analysis, the hazard ratio of HF was 4.05 (95% CI, 3.43–4.77) comparing participants who had both higher genetic risk and an unfavorable lifestyle with those having lower genetic risk and a favorable lifestyle.

Conclusions:

Combined lifestyle was associated with incident HF regardless of metabolic or genetic risk status, supporting the recommendation of healthy lifestyles for HF prevention across the entire population.
Victorinus of Pettau and Angelomorphic Theological Traditions
Authors: McCashen Grayden
Published: September 2022

Victorinus of Pettau is often read either as one of many binitarian Latin theologians in the ante-Nicene era or as a simple exegete whose imprecise comments on the relationship between the Word and Spirit are characteristic of his time. This study argues that recent research on “angelomorphic” theology in sources like Revelation and Clement of Alexandria and the reinterpretation of those traditions in Origen offers a new context in which to situate Victorinus. Read in this context, Victorinus’ comments on the Spirit of sevenfold power and the Word imply a more sophisticated and coherent understanding of the Holy Spirit and the Spirit’s relationship with the Word than is usually thought.
Dio come ἀκαλλής. Conseguenze e implicazioni concettuali dell’apofatismo nel Corpus Areopagiticum
Authors: Abbate Michele
Published: September 2022

Within the Neoplatonic tradition, the absolute transcendence of the First Principle—the One-Good, from which the whole reality in its various articulations derives—plays a crucial role. This philosophical perspective implies, particularly in Plotinus and Proclus, some fundamental philosophical consequences, above all the transcendence of the Principle with respect to being and thought as well. This necessarily implies that the One-Good must be conceived of as beyond the intelligible Beauty itself. In this paper I aim to examine the theoretical implications and consequences of this perspective with specific reference to the conception of God’s absolute transcendence outlined within two texts of the Corpus Areopagiticum, overall characterized by the reworking of some fundamental Neoplatonic concepts in the context of Christian theology: the De divinis nominibus and the De mystica theologia. Indeed, in the De divinis nominibus it is shown that the names/predicates attributed to God in the Sacred Scriptures must be understood only in an allegorical-symbolic meaning, because God is above any possible definition. Not even the character of Beauty can be attributed to him, since he radically transcends it: in fact, God constitutes the absolute foundation and the very first source of Beauty itself. Therefore, God must be understood as ἀκαλλής, that is, “devoid of the connotation of Beauty”, precisely because he completely transcends it. In line with this theological and theoretical perspective, in the De mystica theologia a form of radical and absolute apophatism is developed, which in turn must ultimately lead to its own overcoming for the sake of the henosis, the mystical union with God.
Das Verhältnis zwischen Neuplatonismus und Christentum nach Werner Beierwaltes am Beispiel seiner Auslegung des Dionysius Areopagitas
Authors: Scotti Muth Nicoletta
Published: September 2022

The present essay aims first at clarifying Werner Beierwaltes’ understanding of Neoplatonism at large as the accomplishment of Greek philosophy pursued by Plotinus and coherently developed by Proclus. It seeks secondly to locate Beierwaltes’ remarkable effort to trace the “Wirkungsgeschichte” of Neoplatonism. Focus has been placed, thirdly on his understanding of Dionysius Areopagita as the effective mediator of Neoplatonic issues in the Latin philosophical tradition long before the rediscovery of Proclus in the 13. century. Beierwaltes’ understanding of Dionysius’ “Christian Neoplatonism” as a lucky instance of “Hellenization of Christianity” is finally compared with different exegesis provided by Ivánka and Balthasar in the years immediately preceding Beierwaltes’ remarkable Proclus-monography of 1965.
A new edible species of Lactifluus (Russulaceae) from Shorea robusta dominated forests in tropical India
Authors: GHOSH ANIKET , BERA ISHIKA , CHAKRABORTY DYUTIPARNA , HEMBROM MANOJ E. , VERBEKEN ANNEMIEKE , DAS KANAD
Published: September 2022

Macrofungal explorations undertaken to several Sal (Shorea robusta) dominated tropical forests of West Bengal and Jharkhand (India) yielded various wild mushrooms. Studies on these collections revealed an interesting and novel taxon of Lactifluus subg. Lactariopsis which is proposed herein as Lactifluus tropicalis. The new species is presented with both morphological and molecular data and is most closely related to L. leoninus, a species described from Papua New Guinea.
Combretum xylocarpum (Combretaceae), a new liana species from China
Authors: LIANG DAN , YUAN LANG-XING , WANG RUI-JIANG
Published: September 2022

Combretum xylocarpum, a new species from China, is described and illustrated. It is similar to C. acuminatum in leaf shape, spike position, flower structure and hypanthium shape, but obviously different from it by its fewer secondary veins, pale whitish flower petals, ellipsoidal woody fruits with 4 rounded ridges. In addition, the pollen grains of the new species exhibit unique characters comparing to other congeneric allies. Its conservation status is assessed to be Least Concern, according to the IUCN Red List Criteria and Category.
Home Based Racialized Messages Transmitted to African American Students Transitioning to Predominantly White Institutions
Authors: House Sherrell H. , Johnson Deborah J.
Published: September 2022

This study focused on the cultural differences faced by African American students transitioning to a predominantly White institution and the protective factors that aided them with these transitions. In-depth individual interviews were conducted and used as the primary method of data collection for this study. In addition, a focus group session provided member checking opportunity and served to strengthen the trustworthiness of the study. The focus group was also used as a secondary data source to corroborate the key findings from the individual interviews. Analysis revealed participants were exposed to several risk factors in the university context. Students developed coping strategies to combat these risk factors and promote successful transitions from the home to the university.
A Naturalistic Actigraphic Assessment of Changes in Adolescent Sleep, Light Exposure, and Activity Before and During COVID-19
Authors: Rynders Corey A. , Bowen Anne E. , Cooper Emily , Brinton John T. , Higgins Janine , Nadeau Kristen J. , Wright Kenneth P. , Simon Stacey L.
Published: September 2022

The majority of high school–aged adolescents obtain less than the recommended amount of sleep per night, in part because of imposed early school start times. Utilizing a naturalistic design, the present study evaluated changes in objective measurements of sleep, light, and physical activity before (baseline) and during the first wave of the COVID-19 pandemic (during COVID-19) in a group of US adolescents. Sixteen adolescents (aged 15.9 ± 1.2 years, 68.8% female) wore an actigraphy monitor for 7 consecutive days during an in-person week of school before the pandemic (October 2018-February 2020) and again during the pandemic when instruction was performed virtually (May 2020). Delayed weekday sleep onset times of 1.66 ± 1.33 h ( p < 0.001) and increased sleep duration of 1 ± 0.87 h ( p < 0.001) were observed during COVID-19 compared with baseline. Average lux was significantly higher during COVID-19 compared with baseline ( p < 0.001). Weekday physical activity parameters were not altered during COVID-19 compared with baseline, except for a delay in the midpoint of the least active 5 h ( p value = 0.044). This analysis provides insight into how introducing flexibility into the traditional school schedule might influence sleep in adolescents.
Novel design of honeycomb hybrid sandwich structures under air-blast
Authors: Patel Murlidhar , Patel Shivdayal
Published: September 2022

In this study, dynamic explicit analysis was performed to examine the air-blast performance of various hybrid sandwich designs in terms of face plate deflections and energy dissipation capacity under the conventional weapons effects program (CONWEP) air-blast loads ranging from 3 kg to 8 kg trinitrotoluene for stand-off distance ranges from 150 mm to 200 mm. The blast resistance of honeycomb sandwich configurations was evaluated using steel honeycomb with different core topologies, crushable Al foam-filled steel honeycomb, and steel or steel with 3D Kevlar/polypropylene laminate employing fiber metal laminate (FML) front face. For an accurate prediction of the deformation mechanism of all steel parts, the Johnson-Cook (J-C) model was used. The composite failure criteria of Hashin, Puck, and Matzenmiller were implemented to accurately examine the fiber and matrix damage behavior. The novel hybrid design of the honeycomb sandwich structure’s blast resistance is improved by the employment of foam-filled honeycomb, an FML front face, and a circular honeycomb core. In comparison to other sandwich configurations, a novel designed hybrid sandwich construction composed of foam filled circular honeycomb with FML front facing and steel back facing (FCH-1KP0.5) achieved the highest blast resistance due to its lowest face deflection with the smallest plastic dissipation energy.
Endorsing negative intergroup attitudes to justify failure to confront prejudice
Authors: Szekeres Hanna , Halperin Eran , Kende Anna , Saguy Tamar
Published: September 2022

While most people believe they would speak up against prejudice, many fail to do so. We identify a harmful consequence of such inaction through examining its impact on bystanders’ own prejudice. Across four studies in two countries ( N = 1,003) using a behavioral paradigm and experimental pretest–posttest design, participants witnessed prejudice and discrimination against an outgroup minority (Jewish/Roma in Hungary, Muslim/Latinx in US). Drawing on self-justification theories, we predicted and found across Studies 1–3 that those who had an opportunity but did not confront, endorsed more negative intergroup attitudes following the incident both compared to their own prior attitudes and to control groups—that is, those who witnessed the same prejudice but had no opportunity to confront and those who did not to confront different (nonintergroup) prejudice. In Study 4, the proposed effect occurred only among those who initially valued confronting. We suggest that failure to speak up amplifies prejudice in society.
Avoiding backlash: Narratives and strategies for anti-racist activism in Mexico
Authors: Rejón Piña René Alejandro
Published: September 2022

Structural race-based inequalities in Mexico cannot be denied. Anthropologists and social scientists have thoroughly documented racism at both personal and systemic levels. Following I.M. Young’s framework, this paper identifies two possible pathways for the anti-racist movement in Mexico: the liability and the social connection models. The former uses guilt to assign responsibility —it requires an agent to be voluntarily and causally connected to injustice; the latter does not isolate perpetrators but assigns responsibility to all agents who contribute (voluntarily or not) by their actions to the structural processes that produce injustice. After examining the trajectory of the Mexican anti-racist movement, this paper demonstrates that activists are relying too heavily on the liability model. Furthermore, drawing from ethnographic material from Brazil and the United States, the paper suggests that this model is not only unnecessarily confrontational and ineffectual, but potentially counterproductive for the anti-racist movement, as it is prone to provoke a defensive response. In turn, this paper suggests focusing on the structural nature of racism in Mexico and developing ways to communicate this effectively, in order to foster the positive prospects of successful anti-racist activism.
Addressing Racism, Politics and the Pivotal 2018 Midterm Point: Social Network Analysis of Black Lives Matter Twitter Discourse
Authors: LaPoe Benjamin R. , LaPoe Victoria Leigh , Carter Olson Candi S. , Hazarika Bharbi , Woellert Allyson
Published: September 2022

This study examines Twitter data collected by Netlytic building up to the 2018 midterm election date as well as one month after. We conducted a social network analysis and a semantic textual analysis of the data. Prior research on network discourse of Black Lives Matter, a social movement organically created from a hashtag on social media following the acquittal of Trayvon Martin's killer George Zimmerman, found Black victims of police brutality and systemic racism were victim blamed. This present study maps tweets, showing communication networks formed around Black Lives Matter and what the networks communicated. Through our analysis, eight distinct virtual community networks emerged.
Designing a Course in Business Communication
Authors: Andrews Deborah C.
Published: September 2022

Design thinking, broadly understood as an organizational and entrepreneurial process aimed at innovative problem solving, has been productively incorporated by scholar-teachers in rhetoric, writing studies, and technical communication. Business communication offers similar opportunities. After briefly explaining design thinking and reviewing related scholarship and pedagogy, the article traces the process of creating an innovative course in business communication through each phase or mode of this recursive method: empathizing with users, defining the problem, ideating and prototyping solutions, and testing and evaluating the prototypes. The article positions course design as a project grounded in radical collaboration, with diverse colleagues as well as students.
“We Do Everything”: The Broad, Evolving, Varied, and Tentative Corporate Communication Field
Authors: Fyke Jeremy P. , Schmisseur Amy , Webb Nathan G. , Vaughn Mary , Davis Jimmy
Published: September 2022

Through the reflections of professionals occupying a variety of corporate communication roles, our aim was to understand what the corporate communication profession looks like in the current marketplace and the career pathways professionals take. We find that roles and functions are “broad and blurred” and “evolving and escalating,” while pathways and job titles are “varied and vacillating” and “tentative and time bound.” Our article offers theoretical and practical implications for industry and academic professionals looking to bridge the gap between the classroom and the marketplace. We end with pedagogical and curricular implications for corporate communication educators.
A new model for general practice-led, regional, community-based, memory clinics
Authors: Disler Rebecca , Pascoe Amy , Anderson Holly , Piejko Ewa , Asaid Adel , Disler Peter
Published: September 2022

Background

Dementia is a major international health issue with high impact on the patient, relatives, and broader society. Routine screening for dementia is limited, despite known benefit of early detection and intervention on quality of care and patient outcomes. Screening is particularly limited in rural and regional areas, despite high burden and projected growth of dementia in these populations. The current study aimed to implement a new general practitioner (GP) led, multidisciplinary, model of care providing dementia detection and referral pathway to a community-based specialist clinic across six regional general practices.

Methods

Cross-sectional analysis of dementia screening and referral characteristics in the St Anthony Family Medical Practices group based in the regional area of Loddon-Mallee, Victoria. Data were collected on demographics and relevant medical history. Cognitive state was assessed using the Mini-Mental State Examination (MMSE), GP Assessment of Cognition (GPCog), and Geriatric Depression Scale (GDS). Referrals and referral outcomes were recorded for geriatrician, psycho-geriatrician, or both.

Results

Eight hundred and eighteenth patients over 65 years were screened, accounting for approximately 24.2% of 65 and over presentations for the practice network. Of those screened, 68.9% were indicated for referral and 30.3% of these were successfully referred. Of the indicated patients who received referrals, 34.2% declined. Many who declined referral had intermediate scores on the cognitive assessments utilized.

Conclusion

Standardised models of care, integrated within community services, are necessary to improve access to early detection, referral and quality management of dementia. The St Anthony Memory Service model will be invaluable in informing future service development, and in particular the development of services for people living with dementia in rural and regional communities.
Effect of the combination of bumetanide plus chlorthalidone on hypertension and volume overload in patients with chronic kidney disease stage 4–5 KDIGO without renal replacement therapy: a double-blind randomized HEBE-CKD trial
Authors: Solis-Jimenez Fabio , Perez-Navarro Lucia Monserrat , Cabrera-Barron Ricardo , Chida-Romero Jesus Antonio , Martin-Alemañy Geovana , Dehesa-López Edgar , Madero Magdalena , Valdez-Ortiz Rafael
Published: September 2022

Background

The co-administration of loop diuretics with thiazide diuretics is a therapeutic strategy in patients with hypertension and volume overload. The aim of this study was to assess the efficacy and safety of treatment with bumetanide plus chlorthalidone in patients with chronic kidney disease (CKD) stage 4–5 KDIGO.

Methods

A double-blind randomized study was conducted. Patients were randomized into two groups: bumetanide plus chlorthalidone group (intervention) and the bumetanide plus placebo group (control) to evaluate differences in TBW, ECW and ECW/TBW between baseline and 30 Days of follow-up. Volume overload was defined as ‘bioelectrical impedance analysis as fluid volume above the 90th percentile of a presumed healthy reference population. The study’s registration number was NCT03923933.

Results

Thirty-two patients with a mean age of 57.2 ± 9.34 years and a median estimated glomerular filtration rate (eGFR) of 16.7 ml/min/1.73 m2 (2.2–29) were included. There was decreased volume overload in the liters of total body water (TBW) on Day 7 (intervention: -2.5 vs. control: -0.59, p = 0.003) and Day 30 (intervention: -5.3 vs. control: -0.07, p = 0.016); and in liters of extracellular water (ECW) on Day 7 (intervention: -1.58 vs. control: -0.43, p < 0.001) and Day 30 (intervention: -3.05 vs. control: -0.15, p < 0.000). There was also a decrease in systolic blood pressure on Day 7 (intervention: -18 vs. control: -7.5, p = 0.073) and Day 30 (intervention: -26.1 vs. control: -10, p = 0.028) and in diastolic blood pressure on Day 7 (intervention: -8.5 vs. control: -2.25, p = 0.059) and Day 30 (intervention: -13.5 vs. control: -3.4, p = 0.018).

Conclusion

In CKD stage 4–5 KDIGO without renal replacement therapy, bumetanide in combination with chlorthalidone is more effective in treating volume overload and hypertension than bumetanide with placebo.
Incidence, risk factors, and clinical impact of major bleeding in hospitalized patients with COVID-19: a sub-analysis of the CLOT-COVID Study
Authors: Nakamura Junichi , Tsujino Ichizo , Yachi Sen , Takeyama Makoto , Nishimoto Yuji , Konno Satoshi , Yamamoto Naoto , Nakata Hiroko , Ikeda Satoshi , Umetsu Michihisa , Aikawa Shizu , Hayashi Hiroya , Satokawa Hirono , Okuno Yoshinori , Iwata Eriko , Ogihara Yoshito , Ikeda Nobutaka , Kondo Akane , Iwai Takehisa , Yamada Norikazu , Ogawa Tomohiro , Kobayashi Takao , Mo Makoto , Yamashita Yugo ,   the CLOT-COVID Study Investigators
Published: September 2022

Background

The coronavirus disease 2019 (COVID-19) causes extensive coagulopathy and a potential benefit of anticoagulation therapy has been documented for prevention of thromboembolic events. Bleeding events has also been reported as a notable complication; whereas, the incidence, risks, and clinical impact of bleeding remain unclear.

Method

The CLOT-COVID Study was a nationwide, retrospective, multicenter cohort study on consecutive hospitalized patients with COVID-19 in Japan between April 2021 and September 2021. In this sub-analysis, we compared the characteristics of patients with and without major bleeding; moreover, we examined the risk factors for and clinical impact of bleeding events.

Results

Among 2882 patients with COVID-19, 57 (2.0%) had major bleeding. The incidence of major bleeding increased with COVID-19 severity as follows: 0.5%, 2.3%, and 12.3% in patients with mild, moderate, and severe COVID-19, respectively. COVID-19 severity, history of major bleeding, and anticoagulant type/dose were independently and additively associated with the bleeding incidence. Compared with patients without major bleeding, those with major bleeding exhibited a longer duration of hospitalization (9 [6–14] vs 28 [19–43] days, P < 0.001) and higher mortality during hospitalization (4.9% vs. 35.1%, P < 0.001).

Conclusions

In the real-world clinical practice, the incidence of major bleeding was not uncommon, especially in patients with severe COVID-19. Independent risk factors for major bleeding included history of major bleeding, COVID-19 severity, and anticoagulant use, which could be associated with poor clinical outcomes including higher mortality. Precise recognition of the risks for bleeding may be helpful for an optimal use of anticoagulants and for better outcomes in patients with COVID-19.
RETRACTED ARTICLE: Interrelationships between urban policy and climate, with emphasis on the environment
Authors: Dastjerdi Hassan Kamran , Nasrabadi Narjessadat Hossaini
Published: September 2022

There is growing evidence that projected climate change has the potential to significantly affect public health. Many of these effects are likely to be exacerbated by the risks associated with exposure to heat, floods, and chemical and biological pollution in cities. Identifying the effects of climate change on the environment, and the risks and opportunities of adapting to mitigating climate change can help city policies and planning. The stability of urban systems may be jeopardized if appropriate measures are not taken with the urban climate in the field of environment. Studies show that urban life has always been closely related to the natural environment. One of the most important natural factors involved in the typology of cities, which has a very influential role, is climate. In fact, the characteristics and conditions of geographical spaces, especially cities, are due to the natural and abnormal natural possibilities and limitations of natural geographical factors. Because the city originates from the mathematical and relative position, natural factors, especially climate, have a great impact on the typology and natural and human characteristics of cities. In this fundamental article, a descriptive-analytical method has been tried to examine urban space policies with emphasis on the environmental field. The question that arises here is what effect does climate change have on the type and method of policy- making and policy of urban managers in the field environmental? The results show that cities are climatically divided into desert, mountainous and coastal cities that have their own economic and social characteristics. Since environmental issues in any country are largely due to natural conditions and the characteristics of the human environment, knowledge of natural geography and an understanding of the dialectical relationships between the environment and humans are important for analyzing geographical issues. And has a significant role in managing space policy, especially urban space.
Implementation of a software defined FLISR solution on an active distribution grid
Authors: Leniston Darren , Ryan David , Power Clem , Hayes Paul , Davy Steven
Published: September 2022

Background: The resiliency of the distribution grid is of increasing concern to the distribution system operator (DSO) due to factors such as climate change and the resulting faults caused by inclement weather conditions, leading to service disruption to consumers. Loss of service negatively affects key performance indicators (KPI) of the DSO, such as customer minutes lost (CML) and customer interruptions (CI), leading to financial penalties imposed by the regulator.

Methods: In this paper we propose a software-driven Fault Location, Isolation and Service Restoration (FLISR) solution, leveraging modern software and communication technologies married with the DSO's existing infrastructure, to aid fault detection and resolution, with the aim of reducing CMLs & CIs and curtailing the financial penalties incurred.

Results: The proposed FLISR solution was trialled in an area of south-east Ireland which sees a higher count of service loss as compared to more inland areas, providing an ideal environment to gauge the effectiveness of the solution. It was found that the solution generated outputs that could potentially lead to the resolution of fault events faster than the current systems in place by the DSO.

Conclusions: Based on the results gathered from operating the FLISR solution on an active grid, it has demonstrated that leveraging modern software technologies in tandem with existing grid infrastructure benefits the DSO with reference to grid management and operations and the customer in terms of quality of service site.
Modeling the molecular structures and dynamics responsible for the remarkable mechanical properties of a plant cell wall
Authors: Geitmann Anja , Mulder Bela M. , Persson Staffan , Spalding Edgar P.
Published: September 2022

The primary plant cell wall is a hydrated meshwork of polysaccharides that is strong enough to withstand large mechanical stresses imposed by turgor while remaining pliant in ways that permit growth. To understand how its macromolecular architecture produces its complex mechanical properties, Zhang et al.1 computationally assembled a realistic network of cellulose microfibrils, hemicellulose, and pectin. The simulated wall responded to computationally applied stress like the real wall on which it was based. The model showed the location and chemical identity of stress-bearing components. It showed that cellulose microfibril interactions and movements dominated the wall’s mechanical behavior, while hemicellulose and pectin had surprisingly minor effects.
EXPERIMENTAL INVESTIGATION ON THE DAMAGE EFFECT TO PARTIALLY FILLED FUEL TANKS BY REACTIVE MATERIAL PROJECTILE IMPACT
Authors: XIE JIANWEN , ZHENG YUANFENG , WANG HAIFU
Published: September 2022

To explore the potential of PTFE/Al/W reactive material projectile (RMP) in damaging the partially filled fuel tanks, a series of ballistic experiments have been conducted to investigate the damage effect. The experimental results show that both the impact position and the impact velocity of the RMP have significant influence on the damage behavior. For mechanism consideration, the energy release characteristics of RMP closely related to the impact velocity; meanwhile, the fuel/air mixture layer is more flammable than the liquid fuel, and the impact-induced high-temperature deflagration of RMP can generate enough ignition sources. However, when the fuel tank does not disintegrate under the impact, the stored liquid fuel will not spurt out and mix with the surrounding air, only leading to flash-ignition. The sustained combustion only occurs when the RMP successfully causes the fuel tank to disintegrate.
THE HIT POINT DEPENDENCE IN THE INTERACTION BETWEEN LONG ROD PROJECTILES AND EXPLOSIVE REACTIVE ARMOUR
Authors: CLEMENTZ STEFAN , LIDÉN EWA , ANDERSSON OLOF
Published: September 2022

Long rod projectiles interacting with explosive reactive armour consisting of two flyer plates sandwiched around a high-explosive material is studied numerically and experimentally to understand the influence of hit point on the fracture and deformation behaviour of the projectile. The results shows that fracture, deformation and consumption of the projectile occurs mainly due to interaction with the plate moving in the same direction as the projectile. As the time span of this interaction is sensitive to the hit point, the hit point dependence should be taken into account when considering using explosive reactive armour as protection.
ENHANCED DAMAGE EFFECT OF REACTIVE FRAGMENTS OBLIQUE PENETRATING TITANIUM ALLOY PLATES
Authors: XIANG JING-AN , SUN TAO , WANG HAIFU
Published: September 2022

Focusing on the reactive fragments oblique penetration behavior, a series of penetration experiments at velocity of 630-1040m/s at 0-60°were conducted. The results show that the area of perforation hole at 30° increase 143.53% compared with that of normal penetrations, ricochet occurs at 60°. The perforation size at critical velocity (v =705m/s) is much larger than that at higher velocity (v=734m/s) when both oblique penetrated at 30°. The damage zone of front titanium alloy plate was divided into 5 zones according to the morphology of damaged plate. The analytical mode considers both kinetic energy and chemical energy of reactive fragment is developed to reveal the mechanism of enhanced damage effect of reactive fragment oblique penetrating at critical velocity.
DYNAMIC POLYMERIC FOAM EVALUATION TO MINIMIZE BEHIND ARMOR BLUNT TRAUMA (BABT): FROM MATERIAL CHARACTERIZATION TO SIMULATION VALIDATION
Authors: MESPOULET JEROME , ABDULHAMID HAKIM , PEYRATOUT MAËLLE , DECONINCK PAUL
Published: September 2022

This paper deals with the characterization of the dynamic behavior and the damping capability of a polymeric foam that is implemented on soldiers’ chest. Split Hopkinson Pressure Bars (SHPB) experiments have been performed at strain rates ranging from 420 to 5100 s-1. The effect of confinement on the deviatoric behavior of the material has been investigated through unconfined and confined experiments. The damping behavior was studied with the help of ballistic tests. Steel spheres were launched on the foam with an aluminum reference backing. 3D Digital Image Correlation (DIC) with two high speed cameras was set up to monitor the back-face deformation and evaluate the dynamic damping capability of the polymeric foam. At the end, a material model was calibrated using the results of the SHPB experiments and the simulation of the ballistic tests showed a very correction with the impact experiment
Active image optimization for lattice light sheet microscopy in thick samples
Authors: Malivert Maxime , Harms Fabrice , Veilly Cynthia , Legrand Jerome , Li Ziqiang , Bayer Emmanuelle , Choquet Daniel , Ducros Mathieu
Published: September 2022

Lattice light-sheet microscopy (LLSM) is a very efficient technique for high resolution 3D imaging of dynamic phenomena in living biological samples. However, LLSM imaging remains limited in depth due to optical aberrations caused by sample-based refractive index mismatch. Here, we propose a simple and low-cost active image optimization (AIO) method to recover high resolution imaging inside thick biological samples. AIO is based on (1) a light-sheet autofocus step (AF) followed by (2) an adaptive optics image-based optimization. We determine the optimum AIO parameters to provide a fast, precise and robust aberration correction on biological samples. Finally, we demonstrate the performances of our approach on sub-micrometric structures in brain slices and plant roots.
Hrq1/RECQL4 regulation is critical for preventing aberrant recombination during DNA intrastrand crosslink repair and is upregulated in breast cancer
Authors: Luong Thong T. , Li Zheqi , Priedigkeit Nolan , Parker Phoebe S. , Böhm Stefanie , Rapchak Kyle , Lee Adrian V. , Bernstein Kara A.
Published: September 2022

Human RECQL4 is a member of the RecQ family of DNA helicases and functions during DNA replication and repair.RECQL4mutations are associated with developmental defects and cancer. AlthoughRECQL4mutations lead to disease,RECQL4overexpression is also observed in cancer, including breast and prostate. Thus, tight regulation of RECQL4 protein levels is crucial for genome stability. Because mammalianRECQL4is essential, how cells regulate RECQL4 protein levels is largely unknown. Utilizing budding yeast, we investigated theRECQL4homolog,HRQ1, during DNA crosslink repair. We find that Hrq1 functions in the error-free template switching pathway to mediate DNA intrastrand crosslink repair. Although Hrq1 mediates repair of cisplatin-induced lesions, it is paradoxically degraded by the proteasome following cisplatin treatment. By identifying the targeted lysine residues, we show that preventing Hrq1 degradation results in increased recombination and mutagenesis. Like yeast, human RECQL4 is similarly degraded upon exposure to crosslinking agents. Furthermore, over-expression ofRECQL4results in increased RAD51 foci, which is dependent on its helicase activity. Using bioinformatic analysis, we observe thatRECQL4overexpression correlates with increased recombination and mutations. Overall, our study uncovers a role for Hrq1/RECQL4 in DNA intrastrand crosslink repair and provides further insight how misregulation of RECQL4 can promote genomic instability, a cancer hallmark.
The Winnipeg Intraspinal Pressure Monitoring Study (WISP): A protocol for validation of fiberoptic pressure monitoring for acute traumatic spinal cord injury
Authors: Dhaliwal Perry , Wilkinson Marshall , Zeiler Frederick A.
Published: September 2022

Background

Research efforts have been focused on limiting secondary injury after traumatic spinal cord injury by performing spinal decompression and early optimization of spinal cord perfusion. The Winnipeg Intraspinal Pressure Monitoring Study (WISP) was designed to validate the technique of intraspinal pressure monitoring at the site of injury using a fiberoptic pressure monitor placed at the site of injury.

Objectives

To describe the design of the WISP study.

Study design

Descriptive.

Methods

We explain the current limitations in the available scientific literature around the topic of blood pressure management for acute traumatic spinal cord injury and rational for the WISP study. Then, we describe the design of WISP including the patient selection criteria, study interventions, follow up schedules and outcome measurements. A multitude of future research avenues are also discussed.

Results

The WISP study is a single center pilot study designed to validate the technique of intraspinal pressure monitoring following acute traumatic spinal cord injury. The study involves the measurement of intraspinal pressure from within the subarachnoid space at the site of injury to derive a number of physiological parameters including spinal cord perfusion pressure, spinal cord blood volume, measures of spinal cord compliance and vascular reactivity indices. Twenty eligible patients will be recruited and followed for a period of 12 months with visits scheduled for the first 5 days and 1, 3, 6, and 12 months following surgical intervention.

Conclusions

The WISP study will provide the first attempt in North America at validation of intraspinal pressure monitoring with a fiberoptic pressure monitor at the site of injury. Successful validation will lead to future studies to define optimal spinal cord perfusion pressure, relationships of neural injury biomarkers and outcomes as well as epigenetic studies.

Trial registration

This study has been registered at clinicaltrials.gov (registration# NCT04550117).
Caught on camera: Field imagery reveals the unexpected importance of vertebrates for biological control of the banana weevil (Cosmopolites sordidus Col. Curculionidae)
Authors: Tresson Paul , Tixier Philippe , Puech William , Abufera Bernard , Wyvekens Antoine , Carval Dominique
Published: September 2022

Understanding of ecological interactions is necessary for the application of biological control. Banana is the second most produced fruit worldwide and the banana weevil (Cosmopolites sordidus) is the most important pest of banana and plantain. Its biological control remains challenging because of the robustness and cryptic behaviour of the adult and the hidden development of larval stages. Researchers therefore tend to favour conservation biological control of this pest. The commonly used methods for measuring the effects of natural enemies on the regulation of this pest focus on invertebrates and may underestimate the role of vertebrates on biological control. Using cameras, we recorded the predation of sentinel adult weevils in banana plots in La Réunion island that differed in weevil infestation levels and in animal biodiversity. To facilitate image analysis, we used background subtraction to isolate moving parts of image sequences and thus detect predators and predation events. Our cameras recorded only vertebrates as predators of adult banana weevils. The most important predator appeared to be the Asian shrew (Suncus murinus), which was responsible for 67% of the predation events. Other predators included the house mouse (Mus musculus), the oriental garden lizard (Calotes versicolor), and the guttural toad (Sclerophrys gutturalis). The exact time of predation events were determined from the images metadata. It was thus possible to identify predator foraging periods that coincided with activity of adult weevils. Our results confirm that images provide useful information for biological and ecological studies. Along with other recent studies, our results suggest that the role of vertebrates in biological control may be underestimated. Based on these results, we advocate for several management implications such as the installation of hedges, grasslands, and ponds to favour these vertebrate predators of the banana weevil, possibly also favouring other vertebrate and invertebrate natural enemies.