bluuebunny/crossref_metadata_2025 huggingface dataset:
Carbidopa suppresses estrogen receptor-positive breast cancer via AhR-mediated proteasomal degradation of ERα
Authors: Chen Zhiwei , Xia Xing , Chen Heyan , Huang Huirong , Kou Longfa , Chen Ruijie , Chu Maoping , King Kwonseop , Yao Qing , Ganapathy Vadivel , Bhutia Yangzom D. , Zhang Hailin , An Xingsi , Sun Meng
Published: July 2022

Estrogen receptor-α (ERα) promotes breast cancer, and ER-positive cancer accounts for ~ 80% of breast cancers. This subtype responds positively to hormone/endocrine therapies involving either inhibition of estrogen synthesis or blockade of estrogen action. Carbidopa, a drug used to potentiate the therapeutic efficacy of L-DOPA in Parkinson's disease, is an agonist for aryl hydrocarbon receptor (AhR). Pharmacotherapy in Parkinson’s disease decreases the risk for cancers, including breast cancer. The effects of carbidopa on ER-positive breast cancer were evaluated in cell culture and in mouse xenografts. The assays included cell proliferation, apoptosis, cell migration/invasion, subcellular localization of AhR, proteasomal degradation, and tumor growth in xenografts. Carbidopa decreased proliferation and migration of ER-positive human breast cancer cells in vitro with no significant effect on ER-negative breast cancer cells. Treatment of ER-positive cells with carbidopa promoted nuclear localization of AhR and expression of AhR target genes; it also decreased cellular levels of ERα via proteasomal degradation in an AhR-dependent manner. In vivo, carbidopa suppressed the growth of ER-positive breast cancer cells in mouse xenografts; this was associated with increased apoptosis and decreased cell proliferation. Carbidopa has therapeutic potential for ER-positive breast cancer either as a single agent or in combination with other standard chemotherapies.
Robust Modelling and Assessing Sustainability of a Construction Supply Chain Network under Uncertainty: A Case Study
Authors: Abdolazimi Omid , Entezari Sarah , Shishebori Davood , Ardakani Majid Alimohammadi
Published: July 2022

The authors have requested that this preprint be removed from Research Square.
Microfluidic-assisted human cancer cells culturing platform for astrobiological applications
Authors: (Podwin) Agnieszka Krakos , Jarosz Joanna , Śniadek Patrycja , Psurski Mateusz , Graja Adrianna , Białas Marcin , Oliszewska Ewa , Wietrzyk Joanna , Walczak Rafał , Dziuban Jan
Published: July 2022

In the paper, the lab-on-chip platform applicable for the long-term cultivation of the human cancer cells, as a solution meeting the demands of the CubeSat astrobiological missions has been presented. For the first time, the selected cancer cell lines – UM-UC-3 and RT112 were cultured on-chip for up to 50 days. The investigation has been done in stationary conditions (without medium microflow) in ambient temperature, and utilizing microflow perfusion system in the incubation chamber assuring typical cultivation atmosphere (37 ºC). All the experiments were performed to imitate the conditions that are provided before the astrobiological mission starts (waiting for the rocket launch) and when the actual experiment is initialized on a CubeSat board in space microgravity. The results of the tests have shown appropriate performance of the LOC platform, especially in the context of material and technological biocompatibility. Cultured cells were characterized by adequate morphology – high attachment rate and visible signs of proliferation in each of the experimental stage. These results are a good base towards further tests of the LOC platform in both terrestrial and space conditions.
E-SOAF Network structure-based web service selection in Social Networks.
Authors: Hafsi Amal , Njima cheyma Ben , Gamha Youssef , Romdhane Lotfi Ben
Published: July 2022

With the growing number of identical web services available today, it's important to meet consumer needs and select relevant services. Many solutions have been presented to this difficult and complex issue. We proposed, in this paper, a Social Web Service Selection Model SWS-SM that exploits the structure of the E-SOAF network to rank web services offered by a discovery process. Our approach takes into account users feedback and suggest involving two metrics in the selection process. The first metric is time sensitivity to give importance to the most recent evaluations. The second metric is user preferences on quality of services to offer consumers services that satisfy their requirements.
Incidence of asymptomatic COVID-19 positivity in cancer patients and effects on therapy.
Authors: Liu Lisa , Ross Nicole M , Handorf Elizabeth A. , Meeker Caitlin R. , Chen Giana , Baldwin Donald , Vijayvergia Namrata
Published: July 2022

Purpose
The coronavirus disease 2019 (COVID-19) pandemic is posing unprecedented challenges for patient care, especially for cancer patients. This study looks at asymptomatic (AS) COVID-19 positivity in cancer patients and its effects on their care.
Methods
We conducted a retrospective chart review of AS patients testing positive for COVID-19 upon screening at Fox Chase Cancer Center between January 2020 and September 2020. Relationships between positive tests and demographics, clinical characteristics, and treatment delays were investigated using conditional logistic regression or Mantel-Haenszel tests.
Results
Among 4143 AS patients who underwent COVID-19 testing, 25 (0.6%) were COVID-19 positive (cases) and these were matched to 50 controls. The median age was lower in the cases compared to that of the controls (64 vs 70 years old, p = 0.04). Of the cases, 10 patients (40%) never underwent their planned oncologic intervention [6/10 (60%) did not require the planned intervention once deemed okay to proceed]. Of the controls, only 1 patient (2%) did not undergo the planned intervention. Of these 15 COVID-19 positive patients who underwent the planned intervention, 11 (73.3%) had a delay related to COVID-19, with a mean delay duration of 18 days (range: 0–49, SD: 16.72).
Conclusion
Cancer patients had lower incidence of AS COVID-19 than general population. Delays that occur due to AS COVID screening are not very long and serve as a tool to limit spread of virus. Further studies will be important in addressing delays in cancer care and concerns of patient safety as the pandemic continues.
Effects of aging time on microstructure and oxidation behavior of Inconel 690 alloy
Authors: Pang Baolin , Wang Man , Shen Yuegang , Xi Xiaoli
Published: July 2022

The microstructure and oxidation behavior of Inconel 690 alloy were investigated after aging at 850°C for different times. Also, the relationship between structural stability and oxidation behavior was analyzed. Cr23C6 appeared at grain boundaries after aging, and the shape and size of Cr23C6 changed significantly with aging time. Besides, the mechanical properties and oxidation behavior also changed with aging time. The hardness decreased first, then increased, and finally decreased to be stable. The type of oxide layer changed from (Cr, Fe)2O3 to NiCrO3, and then to (Cr, Fe)2O3 again. Oxidation shedding occurred after aging for 504 h. And, there was a porous zone beneath the oxide layer when the aging time reached 720 h. The results indicated that aging time had a significant effect on the structure stability and oxidation behavior.
Stereotactic body radiation therapy (SBRT) increases anti-PD-1 antitumor activity by enhancing the tumor immune microenvironment in mice with metastatic hepatocellular carcinoma
Authors: Xu Ke , Gu Tao , Su Ke , Guo Lu , Liu Xin , He Bingsheng , He Jie , Liu Hanlin , Xiao Rui , Chi Hao , Tang Xue , Ye Qinni , Zhou Xue , Liu Yingpeng , Xiong Jie , Wang Pan , Li Han , He Kun , Han Yunwei
Published: July 2022

Background: Whether stereotactic body radiation therapy (SBRT) can increase anti-PD-1 antitumor activity by enhancing the tumor immune microenvironment in mice with metastatic hepatocellular carcinoma Methods: Patients with metastatic HCC treated with intensity-modulated radiation therapy (IMRT) in combination with immunotherapy (n=13) were retrospectively analyzed by comparing its efficacy with that of immunotherapy alone (n=12) as well as untreated (n=20) patients with metastatic hepatocellular carcinoma. Animal experiments were also divided into a control group, a PD-1 antibody group, an SBRT group, and an SBRT combined with a PD-1 antibody group. The growth curves of body weight, irradiated tumor (the primary tumor), and non-irradiated tumor (secondary tumor) were plotted for each group of tumor-bearing mice. For this study, we used flow cytometry to examine effector CD8+ T cells expression in both irradiated and non-irradiated tumors, the CD4+ T and CD4+/CD8+ T cells ratio in the spleen, and used Elisa to analyze the concentrations of IFN-γ and IL-10 in serum. Tumors were additionally stained with immunohistochemistry Ki-67 and TUNEL. We used hematoxylin-eosin (HE) staining of kidney, liver, lung, heart, and spleen to assess the anti-tumor activity of each group of hormonal mice and their tolerance to determine the safety of the approach.Results: Clinical results: The median survival of IMRT+PD-1 group, PD-1 group, and control group were 17.5 months (95CI 13.2-21.8), 12.5 months (95CI 9.0-16.0), and 5.2 months (95CI 5.5-12.9), respectively (P < 0.001). SBRT combined with PD-1 antibody improved tumor control in both radiated and non-radiated tumors, resulting in a complete cure of the half of mice in animal studies. This was linked to an increased in CD8+ effector T cells infiltration triggered by radiotherapy. HE staining of mice in the SBRT combined with the PD-1 treatment group suggested no damage to the liver, spleen, lungs, kidneys, or heart.Conclusions: This study showed that SBRT, while being well-tolerated, significantly increased anti-PD-1 antitumor activity by enhancing the tumor immune microenvironment in mice with metastatic hepatocellular carcinoma without significant toxic side effects.
A multibiomarker approach to assess the ecotoxicological effects of diclofenac on Asian clam Corbicula fluminea (O. F. Müller, 1774)
Authors: Yuan Nan , Wu Jiasang , Zheng Mengyan , Wang Hongkai , Bao Erqin , Chu Yaoyao , Hu Fengxiao
Published: July 2022

Diclofenac (DCF), one of the most current and widely used nonsteroidal anti-inflammatory drugs (NSAIDs), has been frequently detected in aquatic environments worldwide. However, the ecotoxicological effects of DCF on freshwater invertebrates remain largely unknown. In the present study, Corbicula fluminea were exposed to environmentally relevant concentrations of DCF (0, 2, 20 and 200 µg/L) for 28 days, and the potential adverse effects of DCF on siphoning behavior, antioxidant responses and apoptosis were investigated. Our results showed that the siphon efficiencies of clams were significantly suppressed by DCF exposure. DCF exerted neurotoxicity via reducing the activity of acetylcholinesterase (AChE) in gills and digestive gland of C. fluminea. Exposure to DCF induced antioxidant stress and led to increased malondialdehyde (MDA) levels in both tissues of C. fluminea. Transcriptional alterations of apoptosis-related genes indicated that DCF might induce apoptosis by triggering mitochondrial apoptotic pathway. Our findings will help enhance our awareness of the negative effects of DCF on freshwater bivalves and highlight the ecological risks of DCF in freshwater ecosystems.
Identification of an Oncological Clinical Pathway through Questionnaires to health professionals
Authors: Forrester Mario , Breitenfeld Luiza , Castelo-Branco Miguel , Aperta Jorge
Published: July 2022

Background
Quality oncological care demands the joint effort from different healthcare professionals; therefore, Clinical Pathways could benefit a well-defined group of patients using organized interventions to standardize and increase care processes efficiency. The objective is to develop an integrated patient centered care based on evidence guidelines, patients feedback and best practices to facilitate communication and coordination between the multidisciplinary teams. Official health entities should have tools to identify their oncological clinical pathways for a better institutional organization while aiming to reduce mortality rates and contain costs without compromising the quality.
Methods
With the use of specifically designed questionnaires, we intended to identify a physical oncology clinical pathway. By determining the tumor staging at service arrival; time intervals on tumor suspicion/diagnosis confirmation and diagnosis/first treatment; referral pathway; diagnostic networks and patient Follow-up from a sample of nurses and physicians in a regional health unit, overseeing two regional hospitals (RHs) and 14 primary healthcare centers (PHCs) in a rural interior region in Portugal, we were able to determine and identify the oncology clinical pathway available to cancer patients in the region.
Results
Our findings point to different appreciations of tumor staging at arrival in PHCs and RHs (the latter receiving more metastatic cases); consensus of approximately 4 weeks between tumor suspicion-diagnostic and divided opinions regarding diagnostic-treatment time interval. Moreover, PHCs depend on private laboratories for their diagnostics confirmation, contrarily to the RHs which are resolved locally. Referral pathways indicate almost half of the patients being sent from primary healthcare centers to National Reference Hospitals instead of being treated at a Regional Hospital. Patient follow-up is carried out throughout the local health unit, however, is more developed at RHs. As patients advance through the clinical pathway and approach their treatment stages the number of healthcare professionals reduce leaving mostly Hospital staff involved in this phase and healthcare centers staff primarily involved in diagnostic stages.
Conclusion
Our questionnaires helped gain insight on the clinical pathway to not only illustrate it but also analyze important sections, strength of association between its parts and points of entry for patients into the healthcare system.
Addressing Misclassification Bias in Vaccine Effectiveness Studies with an Application to Covid-19
Authors: Eusebi Paolo , Speybroeck Nico , Hartnack Sonja , Staerk-Østergaard Jacob , Denwood Matthew D. , Kostoulas Polychronis
Published: July 2022

Safe and effective vaccines are crucial to control Covid-19 and to protect persons who are at high risk of complications or death. Test-negative design is a popular option for evaluating the effectiveness of Covid-19 vaccines, but the findings could be biased by several factors, including imperfect sensitivity and/or specificity of the test used for the SARS-Cov-2 infection.We propose a simple Bayesian modeling approach for estimating vaccine effectiveness that is robust even when the diagnostic test is imperfect.We use simulation studies to demonstrate this robustness to misclassification bias for estimating Covid-19 vaccine effectiveness, and illustrate the utility of our approach using real-world examples
A chemical defense deters cannibalism in migratory locusts
Authors: Hansson Bill , Chang hetan , Cassau Sina , Krieger Juergen , Guo Xiaojiao , Knaden Markus , Kang Le
Published: July 2022

Many animals engage in cannibalism to supplement their diets. In swarms of migratory locusts, cannibalism is prevalent and thought to be an important factor for swarm dynamics. We show that in dense swarms, locusts defend themselves by producing an anti-cannibalistic pheromone; phenylacetonitrile (PAN). Both the degree of cannibalism and the production of PAN are density dependent and co-vary. We identify the olfactory receptor responsible for the detection of PAN, and by using genome editing we show that by making this receptor non-functional we abolish the negative response to PAN. We also knock out the gene underlying PAN production and show that locusts lacking PAN lose its protection and are more frequently exposed to intra-specific predation. In conclusion, we reveal an anti-cannibalistic feature built on a specifically produced odor. The system is very likely of great importance in locust swarm dynamics and our results might therefore provide opportunities in locust management.
Feasibility of using the Metaverse as Telecardiology platform: Remote Follow-up of a patient with Vasospastic Angina
Authors: Skalidis Ioannis , Fournier Stephane , Hammilos Michael , Kaldasch Michael , Idrissi Ben El , Kirsch Matthias , Muller Olivier , Skalidis Emmanouil , Maurizi Niccolo
Published: July 2022

The metaverse has recently seen a surge of interest among numerous sectors, including healthcare, but it’s potential impact in patient care and disease diagnosis hasn’t been evaluated yet. We conducted the first medical act inside the metaverse by combining a virtual reality metaverse environment with existing telemedicine innovations, in order to perform a clinical and electrocardiographic follow-up of a patient presenting with vasospastic angina.
Development of Modified Cognitive Behaviour Therapy in Sri Lanka: a feasibility study
Authors: Rodrigo Asiri , Minas Harry , Newton Richard , de Zoysa Piyanjali
Published: July 2022

Introduction- Depression is an important public health issue in Sri Lanka with a high prevalence and significant burden. Depression is under-treated in Sri Lanka. Psychotherapy, an integral part of the treatment, is rarely practiced in the country, partly due to lack of culturally sensitive psychotherapies. Method- An experimental prospective study design was adopted to evaluate the feasibility and safety of modified cognitive behavioural therapy (CBT). Twelve consenting adult patients with depressive disorder received 6 sessions of modified CBT over 10 weeks and were followed-up for 16 weeks thereafter. Participants were assessed with Hamilton Depression (HRSD) and Beck Depression (BDI) and Global Assessment of Function (GAF) scales. Interviews were conducted with patients and clinicians regarding the acceptability of treatment. Results- Eleven out of 12 patients completed the treatment. HRSD, BDI and GAF scores improved significantly (p>0.05) from baseline to both week 10 and 26. All the patients believed that the psychotherapy was useful while all the clinicians reported modified CBT as being feasible and easily deliverable. Conclusion- Culturally modified CBT for depression is acceptable, feasible and probably effective.
High-throughput Li plating quantification for fast charging battery design
Authors: Konz Zachary , Wirtz Brendan , Verma Ankit , Huang Tzu-Yang , Bergstrom Helen , Crafton Matthew , Brown David , McShane Eric , Colclasure Andrew , McCloskey Bryan
Published: July 2022

Fast charging of most commercial lithium-ion batteries is limited due to fear of lithium plating on the graphite anode, which is difficult to detect and poses significant safety risk. Here we demonstrate the power of simple, accessible, and high-throughput cycling techniques to quantify irreversible Li plating spanning data from over 200 cells. We first observe the effects of energy density, charge rate, temperature, and State-of-Charge (SOC) on lithium plating, use the results to refine mature physics-based electrochemical models, and provide an interpretable empirical equation for predicting the plating onset SOC. We then explore the reversibility of lithium plating for varied deposition rates, amounts, and electrolyte compositions, applying our understanding towards development of electrolytes that reduce irreversible Li formation. Finally, we provide the first quantitative comparison of lithium plating in the experimentally convenient Graphite|Li cell configuration compared with commercially relevant Graphite|LiNi0.5Mn0.3Co0.2O2 (NMC). The hypotheses and abundant data herein were generated primarily with equipment universal to the battery researcher, encouraging further development of innovative testing methods and data processing that enable rapid battery engineering.
Abnormal variations of the four factors in osteoporotic fractures
Authors: Binwang
Published: July 2022

Objective: The classical osteoporotic signaling pathways include the four key factors (LRP5, Runx2, Osterix, and RANKL) influencing the regulation of osteogenesis and osteoclastogenesis. The purpose of this study is to investigate the variations of these four factors in bone specimens associated with fractures of osteoporotic rats. Methods: Osteoporotic rats as osteoporotic group were randomly divided into three groups: group A, group B and group C. Non-osteoporotic rats as control group were divided into three groups: A0, B0 and C0, using the same method. The rats were killed on the third day of fractures in groups A and A0, on the seventh day of fractures in groups B and B0 and on the fourteenth day of fractures in groups C and C0. The bone specimens were taken from the femur. The expression level of each factor in bone specimens was detected using RT-qPCR, Western blotting and immunohistochemistry. Results: LRP5, Runx2 and Osterix expressions were decreased in osteoporotic rat fractures and then increased with the increase in time. The expression of RANKL was elevated in osteoporotic rat bone specimens, and then after that, it keeps going up decreased. Conclusion: The four factors can inform on an ideal interventions in the prevention and management of osteoporosis.
Multi-omics assisted breeding for biotic stress resistance in soybean: challenges and opportunities
Authors: Bisht Ashita , Saini Dinesh Kumar , Kaur Baljeet , Batra Ritu , Kaur Sandeep , Kaur Ishveen , Jindal Suruchi , Malik Palvi , Sandhu Pawanjit Kaur , Kaur Amandeep , Gill Balwinder Singh , Wani Shabir Hussain , Kaur Balwinder , Sandhu Karansher , Siddique Kadambot H.M
Published: July 2022

Biotic stress is a critical factor limiting soybean growth and development. Soybean responses to biotic stresses such as insects, nematodes, and fungal, bacterial, and viral pathogens are governed by complex regulatory and defense mechanisms. Next-generation sequencing has availed research techniques and strategies in genomics and post-genomics. This review summarizes the available information on marker resources, quantitative trait loci, and marker trait associations involved in regulating biotic stress responses of soybean. We discuss the differential expression of related genes and proteins reported in different transcriptomics and proteomics studies and the role of signaling pathways and metabolites reported in metabolomic studies. Recent advances in omics technologies offer opportunities to reshape and improve biotic stress resistance in soybean by altering gene regulation and/or other regulatory networks. We recommend using ‘integrated omics’ to understand how soybean responds to different biotic stresses. We discuss the potential challenges of integrating multi-omics for functional analysis of genes and their regulatory networks and the development of biotic stress-resistant cultivars. This review will help direct soybean breeding programs to develop resistance against different biotic stresses.
Comparative study of soft computing models for prediction of scour below two symmetric crossing jets
Authors: Naini Shayan , Karami Hojat , Hosseini Khosrow
Published: July 2022

The scour estimation downstream of the dam’s hydraulic structures is a serious issue and has long been considered an important topic by hydraulic engineers. The literature shows that the computational methods are good alternatives for the prediction of the scour in various hydraulic structures in which the conventional methods demonstrate shortcomings. In the present paper, the different machine learning techniques have been used for the first time to predict the scour below the two symmetric crossing jets. Four different artificial neural networks (ANNs), including feed forward back propagation (FFBP), cascade forward back propagation (CFBP), radial basis function (RBF), generalized regression neural network (GRNN) along with the adaptive neuro-fuzzy inference system (ANFIS), and support vector regression (SVR) were employed and evaluated. Two important scour hole characteristics, namely the maximum scour hole depth, and its location relative to the scour hole origin, are predicted at different crossing angles. The soft computing models are also compared with the traditional empirical methods. The results indicate that the applied computing techniques perform satisfactorily and improve the results remarkably. They can estimate the scour more precisely than the regression models and can be considered robust alternative tools. A detailed sensitivity analysis is also performed on the FFBP that shows the crossing angle parameter has a powerful effect on the predictions. The SVR improved the results to 47% and 31.71% for the scour hole depth and its location in terms of the coefficient of correlation.
Borrower-Based Macroprudential Measures and Credit Growth: How Biased is the Existing Literature?
Authors: Malovaná Simona , Hodula Martin , Gric Zuzana , Bajzík Josef
Published: July 2022

The ever-so-increasing use of borrower-based measures such as loan-to-value, debt-to-income, and debt service-to-income limits has created a demand to better understand the transmission of the policy and its effectiveness. In this paper, we collect more than 700 estimates from 34 studies on the effect of borrower-based measures on bank loan provision. A birds-eye view of our dataset points to a significant fragmentation of the literature in terms of the estimated coefficients. On average, the introduction or tightening of borrower-based measures reduces annual credit growth by 1.6 pp. Using battery of empirical tests, we verify the presence of a strong publication bias, especially against positive and not statistically significant estimates. The bias-corrected coefficient is about half the size of the uncorrected mean of the collected estimates, but remains safely negative. Further, we explore the context in which researchers obtain such estimates and we find that differences in the literature are best explained by model specification, estimation method, and the underlying data characteristics.
Middle-East prevalence of Toxocara cati and Toxocara canis and Toxocara leonina in stray cats and dogs
Authors: Sadr Soheil , Moghaddam Safa , Atazadeh Amir Hossein , Haratizadeh Mohammad Javad , Borji Hassan , Safavi Ehsanallah Afshari
Published: July 2022

Stray cats and dogs are the major risk factors for human toxocariasis and one of the most important public health issues. Accessing and analyzing the prevalence of Toxocara spp. in definitive host may help control and prevention of human toxocariasis. This systematic review and meta-analysis is the first study in Middle east, directed to estimate the prevalence of Toxocara cati, Toxocara canis and Toxocara leonina infection in cats and dogs by gender, age, geographical location, weather condition and other risk factors. Three English databanks (Scopus, PubMed, and Google Scholar) were searched for published articles about Toxocara parasites of cats and dogs in Middle-East from 1980 to 2022. Of 300 peer-reviewed articles, 40 were included in this review and represented cats and dogs from all over the Middle east countries. The collective prevalence (95% CI) of Toxocara cati infection in stray cats was 7.66%, being highest in north of Iran and lowest in Qatar countries. The collective prevalence (95% CI) of Toxocara canis infection in stray dogs was 26.34%, being highest in north of Iran and lowest in Israel countries. The collective prevalence (95% CI) of Toxocara leonina infection in stray cats and dogs was 2.85%, being highest in Egypt and lowest in Qatar countries. Prevalence of Toxocara leonina was higher in low-income tropical countries and also in young (12 months of age) cats and dogs and also higher in humid weather like north of Iran. Control prevention and of this zoonosis should take greater care by health officials particularly in countries where risk factors and prevalence are highest.
Social Participation Type and Career Adaptability among Young Adults: An Examination of the Mediation Effect of Promotional and Preventive Regulatory Focus
Authors: Paszkowska-Rogacz Anna
Published: July 2022

The purpose of the presented study was to investigate the relationship between career adaptability and developmental tasks by young adults regarding life orientation, and to check whether self-regulation is a mediator in the relationship between life orientation and career adaptability. In total, 435 young adults aged 18 to 34 years were included. The study used the Social Participation Questionnaire, the Self-Regulation Scale, and the Polish version of the Career Adapt-Abilities Scale-5. Mediation analysis found promotion regulatory focus to be a mediator in the relationship between life orientation and all five categories of career adaptability in the transitive orientation dependence model.
Fuzzy-epo Optimization Technique for Optimised Resource Allocation and Minimum Energy Consumption With the Brownout Algorithm.
Authors: Samariya Jitendra Kumar , Tiwari Rajeev , Obaidat Mohammad S. , Bathla Gaurav
Published: July 2022

Cloud Computing is an eminent and reputable agenda which relies on large-scale distributed processing to provide access to their resources and services. In the cloud environment a rigorous management system is mandatory to collect all information regarding task processing levels and proving impartial resource provisioning through the levels of Quality of Service (QoS). These concerns can be settled by employing a meta-heuristic optimization-based resource management. Subsequently, this paper presents a Fuzzy Emperor Penguin Optimization (Fuzzy-EPO) algorithm-based resource provisioning framework for heterogeneous cloud environment. To deploy the optimal set of virtual machines (VM) to physical machines the VM allocation model is employed. The proposed Fuzzy-EPO algorithm does the VM consolidation mainly to reallocate overloaded VM to under-loaded PM to minimize the migration time and the brownout mechanism is adopted to reduce the rate of energy consumption. CloudSim simulation platform is used to implement the proposed system. The simulation results expose that the proposed Fuzzy -EPO based system is effective in restraining the proportion of SLA violation and increasing QoS requirements for providing proficient cloud service
The Role and Place of the Healthcare System in the Formation of the National Brand
Authors: Reshetniak Yaroslav , Grifo Samantha
Published: July 2022

In the view of the snowballing development of digitalization processes and post-industrial society, the service sector is the main element of sustainable economic development, where human capital plays a key role. In the study, the authors noted that the individual and his needs came to the fore. So, it`s started to play a more significant role in the methodology of evaluation of national brand indices. However, during a deeper analysis, the question arises whether such techniques consider all aspects of the socio-economic life of the individual or focus on some of its elements. The research on this issue became particularly acute during the global SARS-CoV-2 pandemic, when most of the socially active population was forced to work distance and spent more time at home and when their lives depended heavily on the effectiveness of national health systems. This study tried to determine the correlations between the efficacy of national healthcare systems and indicators used in the national brand indices. The methodology of this study involved classical scientific research methods such as systems analysis, scientific abstraction, synthesis, and statistical analysis. Besides, VOSviewer software has been used to analyze a significant number of scientific publications, which include keywords like healthcare and the national brand. The data for bibliometric analysis were retrieved from the Scopus scientometric database. This bibliographic analysis presents the findings on the research directions in the analyzed scientific literature scope. The obtained results allowed us to determine the chronology and geography of publications. The systematization of theoretical results of research issues of assessing the impact of the national health care system on the international image perception of the country showed that this issue is almost undiscovered in domestic and international scientific studies. At the same time, this problem is increasingly important in the practical sphere. To confirm this hypothesis, the authors provide a practical case on the example of the analysis of the methodology of evaluation of national brands based on the Anholt Ipsos Nation Brands Index (NBI) and Best Countries (by US News & World Report). They were analyzed through the prism of assessing the national healthcare system by the Global Health Security Index.
Muğla İlinde Arı Safarinin Uygulanabilirliği Üzerine Bir Değerlendirme (An Evaluation on the Applicability of Bee Safari in Muğla Province)
Authors: Çukur Figen , Çukur Tayfun
Published: July 2022

Günümüzde ziyaretçilerin değişen seyahat ve tatil anlayışı nedeniyle destinasyon tercihleri farklılık göstermektedir. Nitekim deniz, kum ve güneş tatil anlayışını artık doğa ve kırsalda konaklama ve tatil tercihi almaya başlamıştır. Bu değişim kırsal turizmin gelişimine ivme kazandırmıştır. Kırsal kalkınmada lokomotif görevi gören kırsal turizm yöre ve ülke ekonomisine önemli katkılar sağlamaktadır. Kırsal turizm birbirinden farklı faaliyetleri kapsamaktadır. Bunlardan biri api turizm olup son yıllarda kırsal turizme olan katkıları nedeniyle önemi gün geçtikçe artmaktadır. Api turizm ayrıca kırsal turizme çeşitlilik kazandırırken ziyaretçilerin destinasyon seçiminde de etkili bir faktör olmaktadır. Api turizm içinde ziyaretçiler tarafından ilgi çeken faaliyetlerden biri arı safaridir. Arı safarinin yer aldığı tur programları bir yandan kırsal turizmin gelişimine katkı sağlarken diğer yandan da turizm sektöründe katma değer yaratmaktadır. Muğla ili Türkiye’nin en önemli bal ve arı ürünleri üretim merkezlerinden biri olması nedeniyle arı safarinin uygulanabilirliği açısından önemli bir potansiyele sahiptir. Bu çalışmada Muğla ilinde arı safarinin uygulanabilirliğinin çeşitli kriterler açısından değerlendirilmesi yapılmıştır.
Tüketici Tercihlerini Etkileyen Faktörlerin Metin Madenciliği ve İçerik Analizi ile İncelenmesi: Ekşi Sözlük Krem Çikolata Örneği (Investigation of Factors Affecting Consumer Choice with Text Mining and Content Analysis Technique: Ekşi Sözlük Cream Chocolate Case)
Authors: Berk Osman Nurullah , Değirmen Süleyman , Yılmaz Hasan
Published: July 2022

Yaşanan sosyo-kültürel gelişmeler insanların yaşam biçimlerini değiştirerek beslenme alışkanlıklarında hazır ve atıştırmalık gıda ürünlerine yönelmelerine neden olmuştur. Krem çikolatanın tüketicilerin gündelik yaşamında önemli yere sahip olmasına karşın marka tercihinde etkili faktörlere yönelik literatür tarandığında kapsamlı araştırma yapılmadığı gözlemlenmiştir. Araştırmadaki amaç tüketicilerin krem çikolata markaları üzerine olan görüş ve düşüncelerini saptayarak, tercihlerini etkileyen faktörleri belirlemektir. Araştırmada ekşi sözlükte krem çikolata markalarına yönelik 574 sözlük yazarının yorumuyla oluşan veri seti incelemeye alınmıştır. Tüketici istek ve ihtiyaçlarını belirlemede ve pazar araştırmalarında büyük verilerin kullanımı her geçen gün artış göstermektedir. Bu bağlamda ekşi sözlükteki yorumlar büyük veri seti olarak değerlendirilebilmekte ve krem çikolata pazarına yönelik öngörü sağlayabilmektedir. Veriler WebHarvy uygulaması ile Ekşi Sözlük’ten alınarak, Python programında karşılaştırmalı analiz yapılmıştır. MAXQDA programı kullanılarak sözlük yazarlarının yorumları içerik analizine tabi tutulmuştur. Araştırma sonucunda veri setinde 29 farklı marka tespit edilmiş; lezzet, sağlık, fiyat başta olmak üzere üç temel değişken belirlenerek önem dereceleri ve bu değişkenleri etkileyen faktörler saptanmıştır. Tüketici nezdinde önem derecesi en yüksek olan faktör fındık oranı iken kullanılan yağın içeriği, şeker miktarı ve katkı maddeleri ikinci sırada yer almaktadır. Menşei, yerellik, doğallık ve marka benzeştirmesi öne çıkan diğer önemli unsurları oluşturmaktadır.
Otel İşletmelerinin Gıda İsrafı Konusundaki Eğilimleri: Kastamonu Örneği (Tendencies of Hotel Businesses on Food Waste: The Case of Kastamonu)
Authors: Şenel Furkan Musa , Çılgınoğlu Hakkı
Published: July 2022

Gıdalar, üretimden son tüketiciye varıncaya kadar çeşitli basamaklardan geçer. Bu basamaklar esnasında türlü sebeplerden dolayı gıda kayıpları yaşanmakta ve bu kayıpların sonucunda da israf durumu ile karşılaşılmaktadır. Gıda ve Tarım Örgütü (FAO); 1,3 milyar ton gıdanın her sene israf edildiğini, bunun mali karşılığının da yaklaşık 990 milyar dolar değerinde olduğunu bildirmiştir. En çok israf yapan ülkeler sıralamasında yaklaşık 7,7 milyon ton ile 13.sırada yer alan Türkiye’de yılda kişi başı ortalama 93 kilogram gıda israf edilmektedir. Türkiye’nin büyük şehirlerinde yapılan çalışmalarda gıda maddelerinin onda birinin çöplere atıldığı belirtilmiştir. Bu oran, turizm işletmelerinin yoğun olduğu bölgelerde daha da fazla görülmektedir. Türkiye’deki turizm işletmelerinin varlığı göz önüne alındığında, yapılan gıda israfı miktarı hesaplanması güç olan noktalara ulaşmaktadır. Bu çalışma Kastamonu Merkez’de bulunan konaklama işletmelerinde meydana gelen gıda atık miktarının, gıda atıklarının en çok hangi öğünde meydana geldiğinin, gıda atıklarının en çok hangi süreçlerde meydana geldiğinin, COVID-19’un israf üzerindeki etkisinin tespiti; gıda atıklarının değerlendirilme şekillerinin belirlenmesi ve işletmelerin gıda israfını önleme uygulamalarının incelenmesi amacıyla yapılmıştır. Çalışmada veri toplama yöntemi olarak derinlemesine görüşme yöntemi kullanılmıştır. Veri toplama aracı olarak ise yarı yapılandırılmış görüşme formu tercih edilmiş, katılımcılara yöneltilecek sorular önceden belirlenmiştir. Türkiye’de gıda israfının ciddi bir boyutta olduğu ve israfı önlemek için yapılacak her bir uygulamanın geleceği daha iyi bir şekilde planlayabilmek adına büyük önem arz ettiği görülmüştür. Araştırmada ulaşılan sonuçların hem sektördeki uygulamalara farklı bir bakış açısı sunması hem de literatüre katkı sağlaması beklenmektedir.
Turizmde Bilişim Sistemlerinin Yer Aldığı Çalışmaların Bibliyometrik Analizi (Bibliometric Analysis of Studies involving Information Systems in Tourism)
Authors: Özmen Esra
Published: July 2022

Bilişim sistemleri hayatımızda karşılaştığımız her durum ve ortamda kullanılmaktadır. Örneğin bankacılık sektöründe gerçekleştirdiğimiz havaleler ve yatırımlar gibi işlemlerde, eğitim sektöründe ders alma ve verme süreçlerinde, pazarlama sektöründe ürünün sunulmasından satışına kadar bütün süreçlerde bilişim sistemlerinden faydalanılmaktadır. Sektörel bazda düşündüğümüzde turizm sektörünün de teknolojinin getirdiği kolaylıklardan faydalanması ve rekabet açısından da avantaj kazanması önem arz etmektedir. Bu çalışma kapsamında turizm alanında yapılan akademik çalışmalarda bilişim sistemlerinin hangi boyutta ele alındığı ortaya koyulmaya çalışılmıştır. Turizm çalışmalarındaki bilişim sistemlerine yer verilme durumuna sistematik bir bakış açısı sağlamak amaçlanmıştır. Bu amaç doğrultusunda alanyazındaki çalışmalar kapsamında bibliyometrik analiz yöntemi kullanılmıştır. Çalışmada Scopus veri tabanında yer alan uluslararası yapılmış çalışmalar alınarak VOSviewer analiz uygulamasında anahtar kelimeler, ülkeler, kurumlar ve dergi boyutlarında analiz edilmiştir. Analiz sonuçlarına göre en çok tekrar eden anahtar kelimelerde “GIS”, atıf alan dergilerde; “Tourism Management”, ve atıf yapılan Ülkelerde “Çin” ilk sırada yer almıştır. Bu çalışmada turizmde bilişim sistemlerine yer verilen araştırmalar bibliyometrik analize tabi tutularak mevcut durumu ortaya koyulmuştur. Gelecek çalışmaların literatür araştırması aşamalarında oldukça yardımcı olacağı düşünülmektedir.
Yeni Normal Gastronomi Trendi: Çevrimiçi Yemek Teslimat Sistemi ve Hayalet Mutfaklar (New Normal Gastronomy Trend: Online Food Delivery System and Ghost Kitchens)
Authors: Boyacı Dorukan
Published: July 2022

Tüm Dünya’yı etkisi altına alan pandemi restoranların servis sistemini de etkilemiştir. İş kayıplarının meydana gelmesi, sosyal mesafe kuralları ve yeni normal uygulaması ile birlikte restoranlar uyum sağlamak ve işlevlerini sürdürebilmek için farklı yöntemler geliştirmiştir. Online yemek sistemlerine ve paket servislere olan ilgi giderek artmıştır. Artan yaşam temposu gibi farklı sebepler insanların yemek ihtiyaçlarını çevrimiçi yemek hizmetleri ile karşılama durumu fazlasıyla artış göstermektedir. Ayrıca pandemi etkisi ve değişen yaşam şartları ile birlikte restoranlar devamlılıklarını sağlamak ve yeni sisteme ayak uydurabilmek içi farklı stratejiler geliştirmeye başlamıştır. Bu stratejilerle birlikte hayalet mutfak kavramı ortaya çıkmıştır. Hayalet mutfaklar yalnızca yemeklerin hazırlanması ve teslimat sistemlerine odaklanmaktadır. İnsanların çevrimiçi yemek sistemlerini kullanarak sipariş vermeleri, hayalet mutfaklarda yemeklerin hazırlanması ve paket servis ile tüketicilere ulaştırması sistemi üzerine kurulmuştur. Bu çalışma gelişen çevrimiçi yemek sistemleri, hayalet mutfak kavramı, hayalet mutfakların avantaj ve dezavantajlarını ve hayalet mutfağın geleneksel mutfaktan farklılıklarını ele alan kavramsal bir çalışmadır. Çalışma sonuçlarına göre restoranların oluşturduğu yeni strateji ve kavramların ilgi gördüğü, günlük hayatta pek çok tüketicinin ihtiyaçlarını karşılaması ve işletme sahiplerinin restorandaki ambiyans ve personel giderleri gibi maliyetleri düşürmesi nedeniyle avantajlı bir uygulama olduğu söylenmektedir.
Turist Rehberleri Bakış Açısıyla Dijitalleşme ve Robot Rehberler (A Study of Digitilisation and Robot Guıdes From The Perspectıve of Tourıst Guides)
Authors: Özalkan Sinem , Özkurt Derya Şimay , Yazıcı Ayyıldız Ahu
Published: July 2022

Bu çalışma turist rehberlerinin dijitalleşmeye bakış açısını, dijitalleşmenin ve robot teknolojisinin rehberlik mesleğine olabilecek muhtemel avantaj ve dezavantajlarını turist rehberlerinin perspektifinden değerlendirmeyi amaçlamaktadır. Çalışmada veri toplama aracı olarak nitel araştırma yöntemlerinden yarı yapılandırılmış görüşme tekniği kullanılmış ve elde edilen veriler içerik analiziyle değerlendirilmiştir. Veriler, ATRO (Aydın Turist Rehberleri Odası)’ya bağlı olarak çalışan 20 turist rehberiyle yapılan yüz yüze görüşmelerle toplanmıştır. Görüşme yapılan turist rehberlerinin turlarında dijital platformlardan Headset, navigasyon, Audio-guide gibi bazılarını kullandığı, özellikle anlatımın zor olduğu yerlerde bu uygulamaların destekleyici rol üstelendiği belirlenmiştir. Turizm endüstrisinde robot rehber kullanımının duygusuz bir anlatımla iletişime engel olabileceği, ancak müze ve ören yerlerinde iş yükünü hafifletmesi açısından avantaj sağlayacağı da ifade edilmiştir. Teknolojinin hızla gelişimi ve hayatın hemen her alanına adapte edilmesiyle birlikte turizm sektöründe de teknoloji uygulamaları yaygınlaşmaya başlamıştır. Bu değişimler turistler ile aktif şekilde iletişim halinde olan turist rehberlerini de büyük ölçüde etkilemiştir. AudioGuide, QR Kod ve sanal gerçeklik gibi uygulamalar turist rehberleri tarafından rakip olarak görülmemeli, uygulamaların turlara adapte edilerek kolaylaştırıcı avantajlarından yararlanılmalıdır.
Burden and Determinants of Open Defecation: The Reality across the Rural and Urban Areas of Osun State, Southwest Nigeria
Authors: Onyemaechi Simeon Beluonwu
Published: July 2022

The burden of open defecation remains a challenge in Nigeria despite various interventions targeted at ensuring uptake of sanitary means of sewage disposal. This study aimed at determining the factors that influence the practice of open defecation in the rural and urban communities of Osun State. A comparative cross-sectional study design was employed. Two hundred and ninety-nine households were enrolled in the rural and 299 households from urban local government, using multistage sampling technique. Data were collected using an interviewer-administered questionnaire and a checklist was used to assess the sanitation of the house. Determinants of open defecation were assessed using binary logistic regression. The burden of open defecation is more in rural areas both at home and when away from home 31.1% and 37.8% respectively; compared with urban areas, indoor, 8.4%, and away from home, 11.7%. Households in rural areas are four times more likely to practice open defecation than those in the urban area (Odds ratio = 3.9, p <0.001). Likelihood of practice of open defecation declined with level of education of male head and increase in wealth index of households. House ownership reduced the likelihood of practicing open defecation by 2.5 (odds ratio = 0.4, p = 0.015). There is a need for more efforts focused especially on the rural areas to achieve the eradication of open defecation in Nigeria. There is a need to promote having toilets in the house especially in rural areas where a significant proportion still lacks access to toilets.
Removal of hydrogen sulfide in biogas from wastewater treatment sludge by real-scale biotrickling filtration desulfurization process
Authors: Arıman Sema , Koyuncu Serdar
Published: July 2022

The biological removal of hydrogen sulfide in biogas is an increasingly adopted alternative to conventional physicochemical processes because of its economic and environmental benefits. In this study, a real-scale biotrickling filtration (BTF) process packed with polypropylene carrier was used to investigate the removal of high concentrations of H2S in biogas from an anaerobic digester. The results show that H2S in biogas was entirely removed under different inlet concentrations of H2S from 2,923 to 4,400 ppmv, and the elimination capacity of H2S in the filter achieved about 52.71 g H2S/m3/h). In addition, the process efficiency was found to be independent of the inlet H2S concentration. The removal of high concentrations of H2S in biogas was accomplished by the BTF process with SOB (Acidithiobacillus thiooxidans), which is active in the acidic environment (pH 1.5–3.5). In addition, the process efficiency was found to be independent of the inlet H2S concentration. Consequently, a real-scale BTF process allowed the potential use of biogas and the recovery of elemental sulfur resources simultaneously.
Okoliczności sprawy a dowodzenie w procesie o nieważność małżeństwa ob exclusionem indissolubilitatis
Authors: Krajczyński Jan
Published: July 2022

Opracowanie jest kolejnym przyczynkiem do zgłębienia, w drodze analizy, merytorycznego bogactwa orzeczeń sędziów Roty Rzymskiej w sprawach o stwierdzenie nieważności małżeństwa z tytułu wykluczenia nierozerwalności. Stanowi próbę zebrania i przedłożenia wybranych zasad prawnych dotyczących okoliczności sprawy, które for- mułują członkowie zwyczajnego trybunału ustanowionego przez Biskupa Rzymskiego dla przyjmowania apelacji (kan. 1443 KPK/83). Poniższe uwagi dotyczące dowodzenia w sprawach o nieważność małżeństwa ob exclusionem boni sacramenti z uwzględnieniem, jak chce Jan Paweł II, „konkretnych uwarunkowań każdego poszczególnego związku”1, stanowią kontynuację rozważań zawartych w artykule pt. „Badanie okoliczności, które pomagają ustalić myślenie i wolę domniemanego symulanta w sprawach o nieważność małżeństwa ob exclusionem indissolubilitatis”
Benefits for Companies by Hiring Workers with Disabilities
Authors: Manuaba Ida Bagus Surya , Hartati Agustina Shinta W. , Emaliana Ive
Published: July 2022

Workers with disabilities are still minimally absorbed in the job market in the formal sector. Even though there are several benefits that the company gets when it employs workers with disabilities. This study uses the library study method and interviews with 2 people with disabilities of which 1 works in the formal sector and 1 works in the informal sector. Although the Law on Persons with Disabilities has set a minimum quota for disabled workers in companies, its implementation has not been in line with expectations. Whereas companies that employ workers with disabilities will get benefits such as a good corporate image because they employ workers with disabilities, create an inclusive work environment.