bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness and clinical benefits of new anti-diabetic drugs: A real life experience
Authors: Piazzolla Giuseppina , Vozza Alfredo , Volpe Sara , Bergamasco Alessandro , Triggiani Vincenzo , Lisco Giuseppe , Falconieri Michela , Tortorella Cosimo , Solfrizzi Vincenzo , Sabbà Carlo
Published: July 2022

We evaluated the clinical impact, in daily clinical practice, of sodium-glucose co-transporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP1RA) therapies in patients with type 2 diabetes. Data from 500 unselected consecutive patients were retrospectively analyzed. Only those with a full assessment at baseline (T0) and after 3 (T3), 6 (T6), and 12 (T12) months of treatment with SGLT2i or GLP1RA were included in the study (n = 167). At baseline, patients had a high mean body weight (BW), abdominal circumference (AC), body mass index (BMI), and HOMA index. Despite normal C-peptide values, 39 patients were being treated with insulin (up to 120 IU/day). During therapy, a progressive improvement in BW, BMI, and AC was observed with both the molecules. Fasting glucose and glycated Hb decrease was already significant at T3 in all patients, while the HOMA index selectively improved with SGLT2i therapy. Renal function parameters remained stable regardless of the drug used. Finally, SGLT2i reduced serum uric acid and improved the lipid profile, while GLP1RA reduced serum levels of liver enzymes. Both the therapeutic regimens allowed a significant reduction or complete suspension of unnecessary insulin therapies. Our real life data confirm the results obtained from randomized clinical trials and should be taken as a warning against inappropriate use of insulin in patients with preserved β-cell function.
Mediated disclosure in asylum encounters
Authors: Jacobs Marie , Maryns Katrijn
Published: July 2022

Discursive input functions as the core decisive element in answering the legal dilemma of whether someone is eligible for international protection. This pleads in favour of strengthening the narrative-discursive component in migration studies by offering a micro-sociolinguistic analysis of interactional data from diverse legal encounters with applicants for international protection. This article adopts a case study approach, bringing together two different data sets collected in a Belgian context. In focusing on asylum claims based on reasons of sexual orientation and gender identity, the article foregrounds discursive tensions emblematic for the treatment of disclosure in and around the asylum procedure. The first part of our article draws on data from the guidance and counselling side of the asylum procedure in examining legal consultations which took place in the lawyer’s office. The second part of our article turns to the communication that takes place during asylum interviews between applicants and asylum officers. Juxtaposing both analyses, reveals how disclosure is complicated by the different stakeholders that mediate the situated interaction as well as by the legal-administrative categories that govern the asylum procedure. The way in which institutional actors and assumptions are deeply implicated in the creation of asylum narratives, is not only at odds with the government’s evaluation premises about how stories come into being in isolation, it also entails a certain level of vulnerability as mediation holds the potential to obscure the indexical load of the asylum seeker’s testimony.
Synthesis and crystal structure of 1-((3R,10S,13R,17S)-10,13-dimethyl-3- (phenylamino)hexadecahydro-1H-cyclopenta[α] phenanthren-17-yl)ethan-1-one, C27H39NO
Authors: Zhang Wen-Wen , Ye Jiang-Hai , Zou Juan , He Kang
Published: July 2022

C27H39NO, orthorhombic, P212121 (no. 19), a = 10.5248(7) Å, b = 12.6248(7) Å, c = 16.8913(9) Å, V = 2244.4(2) Å3, Z = 4, Rgt
(F) = 0.0435, wRref
(F
2) = 0.1033, T = 173(2) K.
Vibration and tribological properties of epoxy-granite composites used as novel foundations for machine elements
Authors: Abdellah Mohammed Y. , Abdelhaleem Ahmed , Ghulman Hamza A. , Abdel-Jaber Gamal Tag
Published: July 2022

Composites have become attractive to many industries today and are a good alternative to many traditional materials. Epoxy granite (EG) is used as a competitive alternative to ground ceramics, especially as a foundation for machine tools. This is because of their high damping ratio compared to other traditional materials such as cast iron. In the present study, a lightweight and cost-effective EG composite material was developed as a new foundation for machine elements. The composite material EG was prepared by mixing epoxy resin (12 wt %) and granite particles by casting method. The crushed granite particles were sieved and separated into coarse particles ≤2.36 ≥ 1.18 mm, medium particles ≤1.18 ≥ 0.6 and fine particles ≤0.6 mm. Vibration modal analysis is performed using an impact hammer to measure the natural frequencies occurring at each material size and the damping ratios. Microbial and fungal resistance is tested to understand applicability in humid environments, and water absorption and soak resistance were also measured. Scratch tests are performed using a top scratch tester to measure scratch width for fine and coarse samples. The electrostatic discharges generated by friction on the rubber and granite-epoxy composite sole are measured. It was found that as the particle size decreases, the damping ratio increases and the damping capability is improved, both microbial and fungal resistance increases, the scratch width is small for fine particles, while it is difficult to achieve for other granite sizes. Electrostatic discharges show a better feel for the composite material, but it is better with fine particles.
Equivalents of maximum principles for several spaces
Authors: Park Sehie
Published: July 2022

According to our long-standing Metatheorem, certain maximum theorems can be equivalently reformulated to various types of fixed point theorems, and conversely. As examples of such theorems, in this paper, we list Zermelo’s fixed point theorem, Brøndsted’s principle, Fang’s F-type theorem, related theorems for locally convex spaces and quasi-uniform spaces. Further we review some few works concerned with our Metatheorem.
Comparing ASTM and JSA Sulfur Trioxide Analysis Methods for Slag Aggregates
Authors: Aljobeh Zuhdi , Gillman Rick , Kolba Tiffany
Published: July 2022

In this study, we investigate various methods for determining the sulfur trioxide (SO3) content of slag aggregates. Proper measurement of the SO3 content is important because high levels of SO3 can result in significant loss of strength of the concrete produced from the slag aggregates. In particular, we analyze two testing methods, one from the ASTM and one from the Japanese Standard Association (JSA), and we compare them to SO3 measurements from portable x-ray fluorescence spectrometry (pXRF). The 3 testing methods are applied to 27 specimens of slag aggregates, which were composed of 5 different types: blast furnace, basic oxygen furnace, electric arc furnace, old bank, and open hearth. The results show that the ASTM measurements closely align with the pXRF measurements, whereas the JSA method produces significantly higher SO3 measurements. Owing to the complexity of performing the JSA testing method, as well as its lack of agreement with XRF measurements, we recommend the ASTM testing method for SO3 over the JSA method.
Performance and Characteristics of Stationary Arc and Rotating Arc-Gas Metal Arc Welded DMR 249 Naval Grade Steel Joints
Authors: Sankar N. , Malarvizhi S. , Balasubramanian V.
Published: July 2022

In this investigation, 12-mm thickness naval grade high-strength low-alloy steel plates were welded by rotating arc-gas metal arc welding (RA-GMAW) and stationary arc-gas metal arc welding (SA-GMAW) processes. The main objective of this work was to carry out the comparative analysis of mechanical properties and microstructural characteristics of the joints fabricated by the outlined welding processes. From this experimental work, it is found that the ultimate tensile strength, yield strength, and impact toughness of the RA-GMAW joint are 15 % higher than those of the SA-GMAW joint. This is because of the formation of a higher volume percentage of acicular ferrite microstructure and island martensite/austenite constituent in the weld metal region of the RA-GMAW joint. Moreover, from the productivity point of view, the number of passes in the RA-GMAW process was minimized to three (from six passes), and the width of the heat-affected zone was also reduced by 45 % to SA-GMAW processes. Overall, the RA-GMAW joints are found to have superior mechanical properties and microstructural characteristics compared to SA-GMAW joints.
Envisioning Care: Responses to the Traumas of “Truth” in an Online Queer Christian Community
Authors: Jarrard Clayton
Published: July 2022

In light of the antagonistic histories of Christianity and the LGBTQ+ community in the U.S., a common hardship experienced by queer Christians is the shame of isolation. Many queer Christians are steeped in queerphobic faith communities, lacking resources to help themselves. Digital spaces have become an innovative way to forge connections around this distinct point of tension between faith and lived experience. In this digital ethnography of an online queer Christian community, care is witnessed to be formative for many, and vital for some. Community members adapt approaches to care in the online domain of Reddit to produce support, belonging, and solidarity for those like themselves who are suffering. Yet this care is also bound by social and political norms, which limit its scope to address the entrenched problems queer Christians face. Central to this experience is the role of “Truth” and how it has been wielded against queer Christians, used to marginalize populations, and exploited to shape American culture.
Efecto sedante de un extracto alcohólico de Valeriana sp en alevinos de tilapia (Oreochromis niloticus) para la reducción de estrés durante transporte simulado
Authors: Montañez Calero Tessy , Díaz Coahila Diego , Angulo Herrera Pedro , Cerro Temoche Luis , Cruz-Castellón César , Vasquez-Quispesivana Wilfredo , Lázaro de la Torre César Aquiles
Published: July 2022

El objetivo del presente estudio fue evaluar el efecto sedante de tres productos: extracto de valeriana (Valeriana officinalis), benzocaína y metanosulfonato de tricaína (MS-222) sobre los niveles de estrés producidos por un modelo de transporte simulado en alevinos de tilapias. En una primera parte se determinó la dosis sedante de los productos con base a las características clínicas que indiquen depresión del sistema nervioso central. En la segunda parte se realizó la sedación y posterior transporte simulado de 3 horas. Se realizó la eutanasia de los peces y se tomaron muestras de sangre de la vena caudal para determinar los niveles de cortisol (ELISA), glucosa (glucómetro portátil), parámetros hematológicos y mortalidad. Las dosis óptimas de sedación fueron para extracto de valeriana, benzocaína y MS-222 de 200, 35 y 75 mg/l respectivamente. Luego de las 3 h de transporte simulado los valores de cortisol y glucosa fueron similares o superiores comparados con el grupo control no sedado. El hematocrito no presentó variación significativa (p>0.05) en el grupo tratado con valeriana, mientras que los otros grupos tratados presentaron valores inferiores al control (p<0.05). Todos los grupos tratados presentaron valores bajos de proteínas totales (p<0.05) y ninguno de los grupos presentó mortalidad. Se concluye que, aunque fue posible establecer un estado de sedación de los alevinos de tilapia con dosis específicas de benzocaína, MS-222 y el extracto de valeriana, las dosis no fueron suficientes para reducir el estrés durante el transporte simulado por 3 h.
Efecto de una formulación probiótica a base de un consorcio de actinomicetos sobre el rendimiento productivo e integridad intestinal en pollos de carne
Authors: Molina M. Daniel , Espinoza C. Sandra , Sialer G. Carlos , Horna I. Dina , Quichua B. Rosalía , Vilchez-Perales Carlos , Cordero R. Aída
Published: July 2022

Se evaluó el efecto de una fórmula probiótica conteniendo un consorcio de actinomicetos sobre el rendimiento productivo e integridad intestinal de pollos de carne de 1 a 28 días de edad criados en baterías experimentales. Se emplearon 320 pollos machos Cobb 500, distribuidos al azar en cuatro tratamientos con ocho repeticiones y diez pollos por repetición: T1, dieta basal (sin promotores de crecimiento); T2, dieta basal + promotores de crecimiento (tilosina 200 g/t, salinomicina + nicarbazina 500 g/t); T3, dieta basal + Bacillus subtilis (100 g/t); T4, dieta basal + consorcio de actinomicetos (100 g/t). A los 21 y 28 días de edad se sacrificaron ocho aves por tratamiento para evaluar la integridad intestinal (histomorfometría intestinal) y peso relativo de órganos. A los 14 días de edad, el consorcio de actinomicetos mejoró significativamente la conversión alimenticia frente al grupo que recibió una dieta basal (p<0.05) y presentó un rendimiento similar frente a los otros grupos tratados (p>0.05). No hubo diferencias estadísticas entre los tratamientos para las variables productivas a los 7, 21 y 28 días de edad (p>0.05). La profundidad de cripta y su relación con la longitud de vellosidad en duodeno y yeyuno fueron influenciadas significativamente por la administración del consorcio de actinomicetos en comparación con el grupo que recibió una dieta basal (p<0.05) siendo estadísticamente similar al resto de grupos tratados (p>0.05) a los 21 días. El peso relativo de los órganos no se vio influenciado por los tratamientos a los 21 días de edad (p>0.05), mientras que el peso relativo del bazo fue estadísticamente menor en el grupo suplementado con el consorcio de actinomicetos frente al tratado con promotores de crecimiento a los 28 días de edad (p<0.05). El consorcio de actinomicetos mejoró el rendimiento productivo e integridad intestinal de forma similar a los promotores de crecimiento y al probiótico comercial bajo evaluación, representando una alternativa para su reemplazo eficaz en la alimentación de pollos de carne.
Revisión sistemática de la situación epidemiológica y análisis genómico del SARS-CoV-2 aislado de perros y gatos domésticos
Authors: Chacón García María Clara , Velásquez Peña María Alejandra , Jaramillo-Hernández Dumar Alexander
Published: July 2022

Se realizó una revisión sistemática sobre la epidemiología de la infección por SARS-CoV-2 en caninos y felinos domésticos, así como el análisis genómico de las muestras del virus secuenciadas de perros y gatos. La revisión sistemática se estructuró a partir del protocolo PRISMA. Los artículos se obtuvieron empleando las palabras clave SARS-CoV-2, COVID-19, perros, gatos, epidemiología, transmisión animal, mascotas, animales de compañía, reservorios animales y zoonosis. Adicionalmente, se seleccionaron todos los genomas del SARS-CoV-2 aislados y secuenciados de perros y gatos reportados en la base de datos EpiCoV™ de la plataforma GISAID. Los genomas se analizaron a través de la herramienta Nextclade para la generación de los árboles filogenéticos respectivos. Los reportes de exposición - infección natural con SARS-CoV-2 abarcaron entre enero de 2020 a octubre de 2021 e incluyeron a 100 perros y 108 gatos positivos a la prueba RTq-PCR. Además, se aislaron 141 secuencias genéticas de SARS-CoV-2 de perros (50) y gatos (91), encontrando las siguientes variantes monitoreadas por las organizaciones de salud pública: las variantes preocupantes (VOC) Alpha, Gamma y Delta, y las variantes de interés (VOI) Iota y Lambda. El linaje viral B.1. ha sido predominantemente aislado y secuenciado tanto en perros como en gatos (13.3%), siendo Norteamérica la región con mayor cantidad de genomas reportados de SARS-CoV-2 en ambas especies (43.6%). El SARS-CoV-2 tiene la capacidad de infectar caninos y felinos domésticos, siendo de interés en salud pública su exposición a VOC: Alpha, Gamma y Delta, y las VOI: Iota y Lambda; probablemente por un efecto “spillover” desde el humano. Sin embargo, estas dos especies tienen baja capacidad de transmitir el virus a otras especies susceptibles, considerando que pueden actuar como un fondo de saco epidemiológico en la dinámica de transmisión del SARS-CoV-2.
3He-α Elastic Scattering Phase Shifts in Various Channels Using Phase Function Method with Morse Potential
Authors: Khachi Anil , Kumar Lalit , Sastri O.S.K.S.
Published: July 2022

Background: Typically 3He-α reaction has been modeled using Gaussian and Hulthen potentials without incorporating the non-local spin-orbit interaction.Purpose: To obtain the scattering phase shifts (SPS) for α-3He radiative capture reaction for partial waves with total angular momentum J = 1/2, 3/2, 5/2, 7/2 having negative parities and J = 1/2 with positive parity, using Morse potential as the model of interaction along with the associated spin-orbit term.Methods: Phase function method is employed for determining phase shifts in an iterative fashion, by making changes to model parameters, to ensure minimisation of mean absolute percentage error (MAPE) w.r.t. the experimental SPS. Results: SPS have been obtained for 1/2+, 1/2-, 3/2-, 5/2- and 7/2- with MAPE values of 3.2, 1.0, 0.8, 17.6 and 6.5 respectively. The corresponding interaction potentials and partial cross-sections have been plotted. The resonance frequencies for the 5/2- and 7/2- scattering states are closely matching with experimental ones.Conclusions: The interaction potentials for different ℓ-channels of 7Be have been constructed by considering Morse potential and spin-orbit terms by considering experimental scattering phase shifts for 3He-alpha reaction.
Application of R-Matrix and Lagrange-Mesh Methods to Nuclear Transfer Reactions
Authors: . Shubhchintak , Descouvemont Pierre
Published: July 2022

Background: Nuclear transfer reactions are a useful tool to study the structure of a nucleus. For reactions involving weekly bound nuclei, breakup effects can play significant role and theoretical calculations can be computational expensive in such cases.

Purpose: To utilize the Lagrange-mesh and R-matrix methods for nuclear transfer reactions.

Methods: We use the adiabatic distorted wave approximation (ADWA) method which can approximately treats the breakup effects in a simpler manner. In our approach, we apply the R-matrix method combining it with the Lagrange-mesh method, which is known to provide the fast and accurate computations.

Results: As a test case, we calculate the angular distribution of the cross sections for the 56Fe(d, p)57Fe reaction, where deuteron breakup effects play important role.

Conclusions: We show that these methods work well in the ADWA framework, and we look forward to applying these methods in coupled channel calculations.
Hangover after Side Branch Stenting: The Discomfort Comes Afterwards
Authors: Volleberg Rick , van den Oord Stijn , Van Geuns Robert Jan
Published: July 2022

The authors report on a patient with recurrent angina at rest and on exertion 2 years after percutaneous revascularisation of the first diagonal branch (D1). Invasive coronary angiography with full functional testing was planned with the tentative diagnosis of coronary vascular dysfunction. Coronary angiography with functional testing revealed a haemodynamically significant intermediate stenosis at the D1–left anterior descending artery bifurcation. Optical coherence tomography demonstrated neointimal bridging and accelerated downstream atherosclerosis that was induced by protrusion of the previously implanted stent into the main branch. Although the overhanging stent was considered insignificant at first, it caused significant discomfort after 2 years. After provisional stenting of the main branch with crushing of the protruding stent and continuous medical treatment, the patient remained free of recurrent angina.
Стейкґолдер-менеджмент як інструмент соціального партнерства у сфері вищої освіти
Authors: Нечітайло Ірина , Борюшкіна Оксана , Назаркін Павло
Published: July 2022

Статтю присвячено розгляду стейкґолдер-менеджменту як інструменту соціального партнерства у сфері вищої освіти. Зазначається, що проблема розвитку соціального партнерства в системі вищої освіти актуалізується у зв’язку з новими вимогами до якості освіти і сучасних освітніх програм, що зумовлює застосування методів та прийомів менеджменту, спрямованих на врахування інтересів заінтересованих сторін (стейкґолдер-менеджменту). На думку авторів, важливо розуміти, наскільки активно вітчизняні заклади вищої освіти запроваджують ті чи інші елементи стейкґолдер-менеджменту, які форми взаємодії зі стейкґолдерами використовують. З огляду на вищевикладене, метою статті є представлення результатів дослідження форм взаємодії зі стейкґолдерами як елементів реалізації стейкґолдер-менеджменту, які імплементовані у практику сучасних закладів вищої освіти. Встановлені наступні елементи системи стейкґолдер-менеджменту у закладі вищої освіти: 1) моніторинг позицій стейкґолдерів; 2) врахування позицій і пропозицій стейкґолдерів; 3) інформування стейкґолдерів; 4) освіта, консультування стейкґолдерів; 5) реалізація спільних проєктів; 6) співпраця на основі регламентованих угод, у тому числі на рівні прийняття рішень. Наводяться результати досліджень, проведених авторами у 2011, 2017 та 2022 рр. У сукупності ці результати дозволили дослідити динаміку розвитку соціально-партнерських стосунків вітчизняних закладів вищої освіти: від вельми розпливчастих уявлень представників університетської спільности і бізнес-структур про сутність соціального партнерства у сфері вищої освіті та спільні цілі (у 2011 р.) – до прийняття конкретних управських рішень щодо взаємодії з ключовими групами стейкґолдерів і практичної реалізації принципів та завдань стейкґолдер-менеджменту (у 2022 р.). Конкретизовано форми взаємодії вітчизняних закладів освіти з внутрішніми та зовнішнім стейкхолдерами. Встановлено, що форми відрізняються високою різноманітністю, а взаємодія не є формальністю, вона являє собою плановану і організовану діяльність, важливість якої повною мірою усвідомлюється усіма залученими суб’єктами.
Depois da dialética
Authors: Caux Luiz Philipe de
Published: July 2022

PUCCIARELLI, Daniel. Materialismus und Kritik: Konzept, Aussichten und Grenzen des Materialismus um Ausgang von der Negativen Dialektik Theodor W. Adornos. Würzburg: Königshausen & Neumann, 2019.
profano transformado em sagrado pelo interdito
Authors: Ribeiro Helano , Souza Laura Silva e
Published: July 2022

Ao longo de suas obras, Georges Bataille e Roger Caillois se concentraram na conexão inabalável entre termos, aparentemente contrários, como interdição e transgressão, homogêneo e heterogêneo e mundos profanos e sagrados. Apesar de esses seis termos estarem ligados entre si, é no último par que este artigo se concentrará, pois tem como objetivo analisar de quais formas lugares, objetos e pessoas podem se transformar em entidades sagradas no romance O Nome da Rosa, de Umberto Eco, usando como base as teorias de ambos os filósofos franceses com o apoio de Giorgio Agamben. Entende-se que tais relações mencionadas acima, embora possam parecer opostas à primeira vista, são, de fato, determinadas umas pelas outras, pois nenhuma delas pode existir por si mesma.
Miocardiopatía Hipertrófica
Authors: Vindas Porras Johanna
Published: July 2022

La Miocardiopatía Hipertrófica (MCH) es actualmente una de las afecciones cardiacas hereditarias más prevalentes. Es definida como una enfermedad del músculo cardiaco adquirida como un rasgo autosómico dominante con expresión variable, causada por mutaciones en uno de varios genes que codifican componentes del sarcómero que llevan a un engrosamiento anormal del ventrículo izquierdo (VI) el cual generalmente es asimétrico, se desarrolla en ausencia de una causa identificable, sin dilatación de cámaras y se asocia con desorganización de las fibras miocárdicas y fibrosis. La evaluación diagnóstica de la MHC se realiza con mayor frecuencia mediante ecocardiografía identificando la hipertrofia ventricular izquierda (HVI), valorando los cambios en los gradientes del tracto de salida del ventrículo izquierdo, el desempeño sistólico y diastólico, así como la morfología y función de la válvula mitral (VM). En cuanto a las estrategias de manejo se utilizan la miectomía quirúrgica o la ablación septal con alcohol para disminuir la obstrucción del flujo de salida y la sintomatología de insuficiencia cardiaca, la colocación de un desfibrilador automático implantable para la prevención de muerte súbita y el uso de fármacos para el control y prevención de fibrilación auricular y accidente cerebrovascular.
Reporte de Caso Clínico: Hidrops Fetal por aloinmunización Rh tratado mediante transfusiones intrauterinas seriadas.
Authors: Morales Vindas Verónica
Published: July 2022

La aloinmunización de glóbulos rojos es la segunda causa inmune más común de enfermedad hemolítica perinatal. A pesar de que se trata de una condición cada vez menos frecuente por los avances en su prevención mediante la administración de gammaglobulina anti-Rh, sigue presentándose con manifestaciones clínicas tan comprometedoras para el feto como lo son el hidrops y la anemia fetal. Se presenta el caso de una mujer embarazada con aloinmunización Rh previamente sensibilizada con manifestaciones de anemia severa e hidrops. El caso es abordado mediante transfusiones intrauterinas seriadas, se describen tanto aspectos técnicos como los resultados perinatales.
Extravasación de medio de contraste: Revisión y Manejo
Authors: Rivera Chavarría Ignacio José
Published: July 2022

Hoy en día se realizan gran catidad de pruebas que utilizan medio de contraste, estas  forman parte de la cotidianidad de la medicina pues son claves en el diagnóstico, estadiaje y tratamiento de un gran  número de  patologías. Su uso trajo un aumento en las complicaciones asociadas,  una de ellas es la extravasación de medio de contraste, que a pesar de ser un evento poco frecuente, puede llegar a tener implicaciones graves. Este artículo revisa las características generales de los medios de contraste así como   información actual en relación a la prevención y manejo de esta complicación.
Actualización sobre enfermedad pélvica inflamatoria
Authors: Rivera Fumero Silvana
Published: July 2022

La enfermedad pélvica inflamatoria corresponde a un desorden ginecológico inflamatorio con repercusiones potenciales en el sistema reproductor femenino. Se define como la inflamación del aparato genital superior, con compromiso que va desde el endometrio hasta las trompas uterinas, ovarios, anexos y hasta peritoneo. Se debe principalmente al ascenso de microorganismos patógenos, en su mayoría relacionados a enfermedades de transmisión sexual, que generan una disrupción de las barreras naturales con posterior propagación de microbios. A pesar de que su diagnóstico continúa siendo un reto, la pronta instauración de medidas terapéuticas se considera vital para reducir complicaciones a largo plazo.
Enfermedad renal crónica
Authors: Zamora Chaves Daniela
Published: July 2022

La Enfermedad Renal Crónica corresponde a un grupo de trastornos heterogéneos que afectan la estructura y la función del riñón, los cuales se manifiestan de diversas maneras según la causa subyacente y el estadio de la enfermedad. Las complicaciones son multisistémicas y pueden comprometer la vida del paciente, así como la calidad de la misma, como es el caso de la hiperfosfatemia en la ERC avanzada, la cual se ha relacionado con una gran morbi-mortalidad. Los tratamientos van dirigidos a tratar las causas subyacentes, principalmente Diabetes Mellitus e Hipertensión Arterial. Además, el objetivo del tratamiento farmacológico y no farmacológico es reducir la presión arterial en los riñones y reducir la albuminuria. Esto cobra mayor importancia en un país como Costa Rica, donde se ha descrito un tipo de enfermedad renal crónica no relacionada a los factores de riesgo tradicionales, conocida como Enfermedad Renal Mesoamericana.
Cirugía de control de daños en pacientes no traumatizados
Authors: Grant Vega Natalia María
Published: July 2022

La sepsis intraabdominal es una de las causas más importantes por la cuales los pacientes son atendidos en los servicios de emergencias, independientemente de su etiología. Se realizó una revisión bibliográfica de las bases de datos de pubMed, Cochrane Library, UpToDate relacionadas a sepsis intraabdominal, así como libros de control de daños relacionados con trauma, además de la solicitud de la base de datos de Bioestadística del Hospital México, de los pacientes egresados con diagnósticos de apendicitis aguda con peritonitis generalizada y diverticulitis aguda con peritonitis aguda en los años comprendidos del 2015-2018; y un cuestionario de 8 preguntas relacionadas con el tema. El objetivo es tener una correlación de información internacional y nacional, para brindar una perspectiva actual del manejo de los pacientes con emergencias abdominales que requieran control de daños.
Biofilms: ¿Enemigos de la cicatrización?
Authors: Brenes Leñero Eduardo , Tinoco Chavarria Valeria
Published: July 2022

Una herida crónica es aquella que presenta un retraso en la cicatrización. Esta puede darse por múltiples razones, entre ellas están: insuficiencia venosa, diabetes mellitus, infecciones y la presencia de biofilms, entre otros. Los biofilms son comunidades polimicrobianas que se adhieren o fijan a una superficie, interviniendo negativamente en el proceso de la cicatrización. En este artículo se profundizará sobre su patogenia en las mismas y se hará referencia a estudios que han demostrado lo anteriormente planteado.
Anatomía quirúrgica del trasplante renal
Authors: Redondo-Sáenz Diego , Cortés-Salas Cristhian
Published: July 2022

La anatomía es de vital importancia en las ciencias de la salud. Aunque su centralidad está demostrada en disciplinas como la Medicina, en otras como la Enfermería queda en entredicho al pretender justificar su importancia mediante objetos de interés ajenos al foco disciplinar correspondiente. La presente revisión bibliográfica busca ejemplificar la importancia de esta ciencia en la Enfermería al tener como objetivo describir la anatomía quirúrgica del trasplante renal y su relación con los diagnósticos de enfermería más prevalentes en este periodo. La metodología del aprendizaje basado en problemas permitió dilucidar las actualizaciones en las bases anatómicas de la técnica quirúrgica del trasplante renal y su influencia en los diagnósticos enfermeros que se presentan antes, durante y después de la cirugía. Se concluye que la anatomía constituye una ciencia de vital importancia para la formación y la praxis de todas las disciplinas de salud, existiendo una retroalimentación bidireccional entre las ciencias morfológicas y la Enfermería.
Molecular evidence for concurrent infection of goats by orf virus and bovine herpesvirus 1
Authors: Koç B. Taylan
Published: July 2022

Orf is a disease of small ruminant animals, including goats and sheep, that is caused by a parapoxvirus. Although the mortality rate is low, economic losses may occur due to the clinical signs. Bovine herpesvirus 1 (BoHV-1) infection is known to cause respiratory and reproductive disorders mainly in cattle; however, it has been found to circulate among goats and sheep as well. In contrast to orf virus (ORFV), BoHV-1 does not induce clinical disease in goats. In this study, we aimed to detect the presence of ORFV by molecular methods and to uncover eventual simultaneous herpesvirus infections masked by orf disease signs. To this end, 82 goats, housed near to a cattle herd, were tested. By polymerase chain reaction (PCR), three goats (3.7%) were found to harbour both viruses, while an additional goat was positive for ORFV only. The PCR products were sequenced and phylogenetic analyses were performed. This study revealed that ORFV and BoHV-1 may be present simultaneously in an animal causing a concurrent infection. These data should be taken into consideration when looking for secondary pathogens in diseased goats, and the prevention methods should be developed accordingly.
Global competence development in EFL teacher training – An interview study on the global content in EFL teacher trainers' courses in Hungary
Authors: Divéki Rita
Published: July 2022

In today's world, education needs to empower students to become active global citizens who are prepared for 21st century challenges and who can solve local and global problems, thus, who are globally competent. To affect lasting change in our education systems, it seems urgent to incorporate the global perspective as early as in initial teacher training, and nurture globally competent teacher trainees. As essentially teachers decide on what and how they teach, it is worth examining how they develop the knowledge dimension of global competence, i.e., what content they teach for global competence development (GCD). The main aim of this study, involving five university tutors involved in EFL teacher training in Hungary, is to inquire into what topics they deal with for GCD, what attitudes they have towards dealing with these topics, and how they decide on the content in their first-year language development courses. Findings suggest that they deal with a variety of global and intercultural issues in their lessons; however, they tend to avoid certain local ones. Overall, they have a reasonably positive attitude towards these issues. Finally, the participants predominantly consider the connection to the syllabus, students' language level, and personal and student interest important when deciding on what topics to deal with in class.
The motivational disposition of international students learning foreign languages in Hungary: Testing the L2 motivation self system in the Hungarian context
Authors: Stamenkovska Tatjana , Kálmán Csaba , Győri János Gordon
Published: July 2022

While the L2 Motivational Self System (L2MSS) (Dörnyei, 2005, 2019) has been researched extensively in the Hungarian context, it has not been used to test international students' motivational dispositions towards learning foreign languages. Therefore, the objective of this paper is to report a study that aimed to test the L2MSS on 34 international students who learned Hungarian or English as a foreign language (EFL) during their studies in Hungary. The pilot questionnaire contained nine scales adapted from Taguchi, Magid, and Papi (2009). Besides the ideal L2 self and ought-to L2 self, the scales measured other influential learning and environmental impacts that exert their influence on the L2 learning experience, the third constituent of the model, with a view to better understanding what motivates international students to learn foreign languages. The findings of the pilot revealed that the adapted instrument worked in the Hungarian context and that international learners' motivational dispositions were mostly affected by learners' attitudes towards the foreign language community. Linear regression analysis revealed that the participants' motivated learning behavior could be predicted by their intrinsic and instrumental motivation. Significant differences were found between male and female respondents regarding their L2 ought-to selves and instrumental motivation. Besides explaining the attitudes that the learners have towards the foreign language community, the findings can be utilized to further enhance learners' motivation once the results are fed back to the community of professionals teaching similar students.
Images of chemical structures as molecular representations for deep learning
Authors: Wilkinson Matthew R. , Martinez-Hernandez Uriel , Wilson Chick C. , Castro-Dominguez Bernardo
Published: July 2022

Implementing Artificial Intelligence for chemical applications provides a wealth of opportunity for materials discovery, healthcare and smart manufacturing. For such applications to be successful, it is necessary to translate the properties of molecules into a digital format so they can be passed to the algorithms used for smart modelling. The literature has shown a wealth of different strategies for this task, yet there remains a host of limitations. To overcome these challenges, we present two-dimensional images of chemical structures as molecular representations. This methodology was evaluated against other techniques in both classification and regression tasks. Images unlocked (1) superior augmentation strategies, (2) application of specialist network architectures and (3) transfer learning, all contributing to superior performance and without prior specialised knowledge on cheminformatics required. This work takes advantage of image feature maps which do not rely on chemical properties and so can represent multi-component systems without further property calculations.

Graphical abstract
The Sharīʿah and the Muslim Feminists’ Public Display of the Female Body
Authors: Uthman Ibrahim Olatunde
Published: July 2022

Muslim feminists in Muslim societies have become increasingly independent and visible professionals in the modern world. They are visible in the public space, especially in the entertainment industry, as they use global information technology to project themselves and their bodies. This brings to the fore the question of how Muslim women negotiate Islamic teachings over the visibility of their bodies. Few studies have interrogated this question in the light of Islamic teachings, hence, the need for this study. This paper aims at a detailed examination of the public visibility of Muslim feminists in the light of the Sharīʿah rulings on the public visibility of the male and female bodies. Laura Mulvey’s Hollywood Theory on entertainment spectatorship, as used in her “Visual Pleasure and Narrative Cinema,” is adopted as the theoretical framework to engage the notions of the lustful male gaze and women’s erotic power of fitnah as prevalent in Islamic discourse. In addition, secondary data drawn from extant literature, interviews, and internet sources are used to interrogate the discourse of five purposively selected Muslim feminists in the context of the Sharīʿah rulings on the erotic power of women and their public visibility. The paper concludes that while Islamic teachings discourage the culture of public nudity by both the male and females, the inequitable treatment of Muslim feminists regarding their public appearance is at variance with the above Sharīʿah rulings.
Participative Finance, Microfinance, and Self Entrepreneurship in Morocco
Authors: Zarfi Adil
Published: July 2022

The main purpose of this study is to investigate the role of participative Finance and Microfinance in Morocco to enhance and empower entrepreneurship. The new banking law N° 103-12 reinforces the legal framework. It offers an opportunity to the participative financial institutions to implement their products and participate in the financial inclusion strategy in Morocco, which can facilitate the access of VSMEs and auto entrepreneurs to several modes of financing. For this reason, it is necessary to determine the place of participative Microfinance in the ecosystem of participative Finance and the necessary conditions for its implementation. It is also necessary to know if the formal financial system is well designed to serve the financing needs of auto entrepreneurs in Morocco. The study proposes a conceptual framework to establish the relationship between participative Finance, Microfinance, and entrepreneurship in the case of auto-entrepreneur schemes. In this regard, it seems necessary to know the degree of importance of financial inclusion and if it is enough to empower the auto entrepreneurs, which also helps to determine the contribution of participative Finance and Microfinance in entrepreneurship. Understanding the overall socio-economic structures in Morocco will help determine the obstacles and level of awareness on the demand or supply side. It will help to know whether the Shariah-compliant products can meet on expectations of the VSEs segment. For this purpose, the perception and attitudes of auto entrepreneurs were analyzed using an online survey. A group of experts' perceptions was also analyzed using a qualitative approach, in which semi-structured interviews were conducted.
Progeria (Hutchinson-Gilford Syndrome): Literature Review and Clinical Case
Authors: Buchinskaya Natalia V. , Akhenbekova Aida Zh. , Bugybay Aliya A. , Kostik Mikhail M.
Published: July 2022

Progeria, or Hutchinson-Gilford Syndrome is a rare disease from the group of laminopathies characterized by premature aging with skin, bones and cardiovascular system lesions. Pathogenesis is based on pathogenic variants in the LMNA gene leading to anomalies in the nuclear membrane morphology, gene expression disruption, chromatin structure changes, mitochondrial dysfunction, DNA repair and alternative splicing defects, and telomere shortening acceleration. Major manifestations of the disease are: skin lesions (scleroderma-like syndrome and pigmented lesions), lipodystrophy, late teeth eruption, teeth crowding, alopecia, nail dystrophy, osteolysis of distal phalanges, hip joints valgus deformation, joints contractures, atherosclerosis, hearing loss, early heart attacks and strokes. Scleroderma-like skin changes, osteoporosis, flexion contractures of hands’ interphalangeal joints, and hip joints osteoarthritis require differential diagnosis with rheumatic diseases. The basic strategy in management of patients with progeria is the prevention and treatment of its cardiovascular manifestations (early strokes and heart attacks, arterial hypertension, and atherosclerosis), as well as the increase of patients’ quality of life and daily activity. The efficacy of therapy in patients with progeria via the use of farnesyltransferase inhibitors (monotherapy; combination with bisphosphonates or statins), retinoids, and 1,25(OH)2 — vitamin D3 is studied. This literature review is updated with clinical case description of a girl with progeria. The diagnosis was confirmed by sequencing of the LMNA gene (Sanger), and previously described pathogenic variant in exon 11 (c.1824C>T, rs58596362) in the heterozygous state (p.Gly608Gly, NM_170707.3) was revealed.
Eurocentrism in Samuel P. Huntington’s Concept of the Clash of Civilisations
Authors:   University of Gdańsk (Poland), Kufliński Mateusz
Published: July 2022

The article is dedicated to an issue of Eurocentrism in American political scientist Samuel P. Huntington’s concept of the clash of civilisations. The arguments presented indicate that Huntington’s concept is pure Eurocentric. I start by mentioning a few of Huntington’s critics (Noam Chomsky, Samir Amin, Arjun Appadurai, and John M. Hobson). The next step includes analysing in detail the “Eurocentrism anatomy” and presenting Eurocentrism as a phenomenon based on two axes, which I call “materialistic” and “epistemological”. In other words, Eurocentrism is a kind of spectrum. Thanks to that, I compare Huntington’s concept with facts from literature embedded in both axes. Apart from other arguments, Eurocentric factors in the clash of civilisations are 1) civilisations in the past, 2) origin of the West, 3) demographic argument, and 4) the downfall of the West. I argue that the clash of civilisations is based on false, Eurocentric assumptions and prejudices.
The Impact of the COVID-19 Pandemic on the Growing Importance of Cybersecurity of Data Transfer on the Internet
Authors:   The Alcide De Gasperi University of Euroregional Economy in Józefów (Poland), Such-Pyrgiel Małgorzata Krystyna , Gołębiowska Anna ,   The Main School of Fire in Warsaw (Poland), Prokopowicz Dariusz ,   Cardinal Stefan Wyszyński University in Warsaw (Poland)
Published: July 2022

Information technologies, ICT and Industry 4.0 are developing particularly fast in the fourth technological revolution. During the COVID-19 pandemic, there has been an increase in the scale of digitisation and internationalisation of remote communication processes and various aspects of economic activity. Digitisation of the economy is currently taking place simultaneously in many areas of economic processes and the functioning of many economic entities and public, financial and other institutions. Many companies, enterprises and public institutions that previously operated mostly or solely offline during the pandemic have switched to remote, electronic operation via the Internet. The development of electronic banking is also increasing, including internet and mobile banking. The share of electronic, cashless payments via the Internet and payments with electronic bank cards is increasing. In addition, in recent years, the range of applications of Data Science, Big Data, and Data Analytics technologies in economics, finance and organisation management, including enterprises, financial and public institutions, has been increasing. Therefore, the importance of implementing analytical instruments for advanced processing of large Data Science data sets in enterprises, financial and public institutions is also growing, including the construction of Big Data Analytics platforms to support organisation management processes in various aspects of operations, including improvement relationship with customers. The scale of cybercrime has also increased during the pandemic, as has the importance of improving cybersecurity techniques and instruments.
To Rattle Dry Bones
Authors: Morain Thomas J.
Published: July 2022

THOMAS J. MORAIN offers reflections on the importance of history and specifically the importance of local and state history. By thinking about historical artifacts, historical processes, and historical places, he emphasizes the critical role that the study and understanding of history plays in articulating the meanings and relationships that bind the present and future to the past.
Stephen C. Lensink, Joseph A. Tiffany, and Shirley J. Schermer, Eds., Household Economy at Wall Ridge: A Fourteenth-Century Central Plains Farmstead in the Missouri Valley
Authors: Bozell Rob
Published: July 2022

Review of: Household Economy at Wall Ridge: A Fourteenth-Century Central Plains Farmstead in the Missouri Valley, edited by Stephen C. Lensink, Joseph A. Tiffany, and Shirley J. Schermer.
An analysis of the different kinds of subjective recognition of university students who are majoring in tourism for good teaching: Application of Q methodology
Authors:   The Tourism Sciences Society Of Korea, Cha Suk-Bin
Published: July 2022

In recent years, Korean universities have made various efforts to improve the quality of classes for students in order to compete for survival in a difficult business environment, such as a decreasing school-age population. This study examined the types of subjective perceptions that university students majoring in tourism have regarding the attributes of good teaching by using Q-methodology. Twenty-seven Q-statements were generated, and 30 university students were selected as the P-sample to conduct Q-classification. The Q-factor analysis revealed three types of perceptions: the professor’s passion & consideration of students (type I), intellectual fulfillment (type II), and employment-related content (type III). The university students correspond to the types I perceived the professor’s passion for teaching and thorough preparation for classes and considering the students’ point of view as important. The students corresponding to type II had the characteristic of considering intellectual curiosity and the feeling of learning a lot as important. The students corresponding to type III perceived practical content related to employment and continuous lecture upgrades with the latest class materials as important. In the analysis of differences among types, it was found that there were differences in the statements by type. Based on the results, the detailed implications necessary for each type of class were presented. The results of research can be used as useful implications by professors to improve the design of instruction.