bluuebunny/crossref_metadata_2025 huggingface dataset:
Unsociability and Psychological and School Adjustment in Chinese Children: The Moderating Effects of Peer Group Cultural Orientations
Authors: Zhao Siman , Liu Mengting , Chen Xinyin , Li Dan , Liu Junsheng , Liu Shihong
Published: October 2022

This study examined the moderating effects of cultural orientations of peer groups on the relations between unsociability and psychological and school adjustment in Chinese children. Participants included 1,092 students (527 boys, M age = 12.21 years) in the sixth grade in elementary schools. Data on individualistic and collectivistic cultural orientations, unsociability, and adjustment were obtained from multiple sources including peer nominations, teacher ratings, self-reports, and school records. Using the Social Cognitive Map method, 193 peer groups were identified. Among the results, unsociability was negatively associated with peer preference and academic achievement in groups low on individualistic orientation but not in groups high on individualistic orientation. Unsociability was also negatively associated with peer preference more strongly in groups with higher scores of collectivistic orientation. The results suggested that, in general, unsociable children performed better in social and academical areas in more individualistically oriented groups and less collectivistically oriented groups. The cultural context of peer groups may play a significant role in shaping social and school adjustment of unsociable children.
Holistic Wellness Coaching for Older Adults: Preliminary Evidence for a Novel Wellness Intervention in Senior Living Communities
Authors: Fullen Matthew C. , Smith Jennifer L. , Clarke Philip B. , Westcott Jordan B. , McCoy Regina , Tomlin Connie C.
Published: October 2022

Although resident wellness is increasingly a priority in senior living communities, there are few programs that promote holistic wellness in later life. A total of 79 residents (ages 71 to 97; M = 84.27, SD = 6.46) from eight senior living communities completed a pilot study of a novel, staff-led wellness coaching program consisting of resident-driven goals and individual and group coaching sessions. Participants completed surveys at three time points (pre-program, post-program, and 1-month follow-up). Repeated measures ANOVAs revealed positive changes in resident health satisfaction, physical quality of life (QOL), psychological QOL, loneliness, relatedness, competence, and sense of purpose. Some of these results (i.e., psychological QOL, loneliness) persisted at follow-up. Residents reported high satisfaction with the program. These findings have implications for the application of holistic wellness frameworks in later life, as well as the development and implementation of wellness coaching programs with older adults.
Root Nodule Microsymbionts of Native Coriaria myrtifolia in Algeria
Authors: Gueddou Abdellatif , Sbissi Imed , Louati Moussa , Ghodhbane-Gtari Faten , Cherif-Silini Hafsa , Gtari Maher
Published: October 2022

Coriaria myrtifolia occurs as natural flora of warm temperate climates of northern Algeria which commonly found in hedges, forest and ravine edges. This actinorhizal species was known to establish a mutualistic symbiosis with members of phylogenetic cluster 2 (including strains associated to Coriaria spp., Ceanothus, Datiscaceae, and Dryadoideae) within the genus Frankia. Attempts to isolate C. myrtifolia microsymbionts from native plants growing in 4 locations in Algeria permitted to only recover asymbiotic Frankia strains (unable to reestablish nodulation and to fix nitrogen) from phylogenetic cluster 4 and several non- Frankia actinobacteria including members of Micrococcus, Micromonospora, Nocardia, Plantactinospora, and Streptomyces genera. The biodiversity of Frankia microsymbionts of C. myrtifolia root nodules was assessed using PCR-amplification followed by partial nucleotide sequencing of glnA1 (glutamine synthetase type 1) gene. On the 12 different glnA1 gene sequences obtained in this study, 9 were detected for the first time, and were mainly closelyrelated to Mediterranean genotypes previously described in the Grand Maghreb countries (Morocco and Tunisia) and in Europe (France) but without clear separations from other cluster 2 genotypes.
Temporal Profile of Kynurenine Pathway Metabolites in a Rodent Model of Autosomal Recessive Polycystic Kidney Disease
Authors: Pires Ananda Staats , Gupta Shabarni , Barton Sean A , Vander Wall Roshana , Tan Vanessa , Heng Benjamin , Phillips Jacqueline K , Guillemin Gilles J
Published: October 2022

Autosomal recessive polycystic kidney disease (ARPKD) is an early onset genetic disorder characterized by numerous renal cysts resulting in end stage renal disease. Our study aimed to determine if metabolic reprogramming and tryptophan (Trp) metabolism via the kynurenine pathway (KP) is a critical dysregulated pathway in PKD. Using the Lewis polycystic kidney (LPK) rat model of PKD and Lewis controls, we profiled temporal trends for KP metabolites in plasma, urine, and kidney tissues from 6- and 12-week-old mixed sex animals using liquid and gas chromatography, minimum n = 5 per cohort. A greater kynurenine (KYN) concentration was observed in LPK kidney and plasma of 12-week rats compared to age matched Lewis controls ( P ⩽ .05). LPK kidneys also showed an age effect ( P ⩽ .05) with KYN being greater in 12-week versus 6-week LPK. The metabolites xanthurenic acid (XA), 3-hydroxykynurenine (3-HK), and 3-hydroxyanthranilic acid (3-HAA) were significantly greater in the plasma of 12-week LPK rats compared to age matched Lewis controls ( P ⩽ .05). Plasma XA and 3-HK also showed an age effect ( P ⩽ .05) being greater in 12-week versus 6-week LPK. We further describe a decrease in Trp levels in LPK plasma and kidney (strain effect P ⩽ .05). There were no differences in KP metabolites in urine between cohorts. Using the ratio of product and substrates in the KP, a significant age-strain effect ( P ⩽ .05) was observed in the activity of the KYN/Trp ratio (tryptophan-2,3-dioxygenase [TDO] or indoleamine-2,3-dioxygenase [IDO] activity), kynurenine 3-monooxygenase (KMO), KAT A (kynurenine aminotransferase A), KAT B, total KAT, total KYNU (kynureninase), KYNU A, KYNU B, and total KYNU within LPK kidneys, supporting an activated KP. Confirmation of the activation of these enzymes will require verification through orthogonal techniques. In conclusion, we have demonstrated an up-regulation of the KP in alignment with progression of renal impairment in the LPK rat model, suggesting that KP activation may be a critical contributor to the pathobiology of PKD.
Exact solutions for the conformable fractional coupled nonlinear Schrödinger equations with variable coefficients
Authors: Hong Baojian
Published: October 2022

In this work, the general algebraic method is proposed for finding some solutions of a conformable fractional coupled nonlinear Schrödinger equation with variable coefficients arising in inhomogeneous fibers with two orthogonal polarization states. With the aid of symbolic computations, many types of new soliton pulse and periodic pulse solutions including complex doubly periodic solutions, solitary wave solutions, and trigonometric function solutions are obtained. Some 3D and 2D numerical simulations about these solutions are portraited, which show the novelty and visibility of the dynamical structure and propagation behavior of the corresponding model. Moreover, we found the W-shaped soliton pulse and the periodic wave pulse can be effectively controlled by changing the relative parameters of the frequency coefficients and orders, which will help us to have a better understanding about the internal structure of this model.
The situated deployment of the Italian presentative (e) hai. . ., ‘(and) you have. . .’ within routinized multimodal Gestalts in route mapping with visually impaired climbers
Authors: Simone Monica , Galatolo Renata
Published: October 2022

Drawing on video-recorded data from pre-climbing route mapping with visually impaired climbers and a sight guide, this study uses conversation analysis to investigate the situated deployment of the Italian presentative (e) hai ‘(and) you have’ within locally routinized multimodal Gestalts. The study shows that the guide uses (e) hai to progress route mapping and engage the athlete in tactile actions that target specific features of the route. In this context, (e) hai is packaged with noun phrases, silent pauses, bodily movements, and touch. The arrangement of such syntactic and embodied components is shown to follow a recurrent trajectory in which, between (e) hai and its grammatical completion, syntactic suspension creates a dedicated slot for guide and athlete to physically attain the target object. Routine embeddedness of (e) hai within such arrangement is shown to provide specific affordances to the athletes to anticipate subsequent action and engage in its embodied implementation.
Experimental analysis of diesel/biodiesel blends with a nano additive for the performance and emission characteristics of CI Engine
Authors: Ahmed Mohd Mujtaba , Pali Harveer Singh , Khan Mohammed Mohsin
Published: October 2022

Recently nano additives have proven their significance in biodiesels to overcome the challenges of fossil fuels in CI engines. The current study examines the performance and exhaust emission characteristics of a CI engine on waste cooking oil biodiesel (WCME) blends with Titanium oxide (TiO2) nano additives. TiO2 of 50 and 100 ppm were added in WCME blends with the help of magnetic stirring, followed by ultrasonication. Test fuel with 100 ppm of TiO2 and WCME30 (30% WCME and 70% neat Diesel) showed a 4.04% improvement in brake thermal efficiency and a 3.3% decrement in BSEC. Moreover, lowered NOx, HC, and CO exhaust emissions by 1.7%, 14%, and 17.46% respectively than neat Diesel. So WCME30 with 100 ppm concentration of TiO2 can be utilized as a potential fuel for a single cylinder four-stroke compression ignition engine with the compression ratio of 18:1.
Philosophical Engagement With the Hebrew Bible/Old Testament: Some Methodological Reflections
Authors: Keefer Arthur
Published: October 2022

A raft of recent “philosophical” interpretations have emerged within biblical studies. They have in common the expectation that ideas from the discipline of philosophy will be helpful for understanding the biblical texts. However, the way in which they engage the two varies, and it is their methods that are teased out in this article. I offer a simple trajectory of approaches for works in this area, marked by two ends of characteristic disciplinary habits: using the Hebrew Bible/Old Testament for philosophical reflection and using philosophy for biblical interpretation. In this, the article sketches a much-needed research profile for a lively subdiscipline.
Assessment Tools for Children who Experience Traumatic Loss: A Systematic Review
Authors: Ennis Naomi , Pastrana Freddie A. , Moreland Angela D. , Davies Faraday , delMas Sara , Rheingold Alyssa
Published: October 2022

Children who experience the traumatic (i.e., violent and/or unexpected) death of a loved one are at risk for a range of adverse developmental and mental health problems, including pathological processes of grief. Over the last decades, conceptualizations of maladaptive grief have varied, resulting in a range of assessment tools and no “gold standard” measure to assess symptoms of prolonged grief in children. The current paper is a systematic review of studies that measured grief in children who experienced traumatic loss in order to determine the measures currently used in the literature with children who experience traumatic loss. Searches were conducted according to the preferred reporting items for systematic reviews and meta-analyses in PUBMED, PsycINFO, and OVID and through hand searches of relevant reference lists. Two authors reviewed each study yielded by searches and conducted data extraction on included studies. Studies were included if they were peer-reviewed, included a measure of grief, and consisted of samples of children (age 18 and younger) whereby at least a portion experienced traumatic loss. Thirty-nine studies met inclusion criteria, from which 17 measures were identified. The most commonly used measure was the Inventory of Complicated Grief ( n = 10 studies) followed by the Extended Grief Inventory ( n = 6). Most studies used different measures and variations of the same measures to assess similar constructs. All but one measure relied on child self-report. More standardization of measurement across studies is needed, along with parent and/or teacher reported measures.
Reflections on the Rega Institute for Medical Research, at the fiftieth anniversary of the Rega Stichting vzw (Rega Instituut vzw, Rega Foundation)
Authors: Clercq Erik De
Published: October 2022

The idea to start the Rega Foundation was conceived in 1971 at an informal meeting organized by Prof. Piet De Somer (where Prof. Alfons Billiau, Prof. André Vlerick and I were also present), before the Foundation was formally created in 1972. From the early years some antiviral compounds, such as BVDU and the aminoacyl esters of acyclovir (from which ultimately valacyclovir evolved) originated. The advent of AIDS in 1981 and the discovery of the etiologic agent (HIV) thereof in 1983 have led to the identification of an avalanche of anti-HIV compounds in which the Rega Institute has played a primordial role. Foremost among these compounds was tenofovir, discovered in collaboration with Antonín Holý from the IOCB (Institute of Organic Chemistry and Biochemistry) in Prague. Tenofovir laid the basis for the treatment of HIV (AIDS) and hepatitis B virus (HBV) infections, and in combination with emtricitabine it was the first chemical ever approved by the US FDA (Food and Drug Administration) for the prophylaxis of HIV infections.
Evaluating Urban Vitality Based on Geospatial Big Data in Xiamen Island, China
Authors: Chen Shili , Lang Wei , Li Xun
Published: October 2022

Urban vitality generally refers to the ability to attract lively businesses and human activities, which largely depends on the urban built environment and human flows. Previous studies that applied the empirical approach to analyze urban vitality from the feature of the urban built environment and the behavior of residents are scarce. This study developed a novel framework for exploring urban vitality on the street scale with geographic big data in Xiamen Island—a livable city in southern China. We measured urban vitality and analyzed its characteristics using the Shannon entropy model based on four dimensions of GIS-based data on the point of interest density, taxi flow density, building density, and road density. We then apply the regression model to explore the relationship between land-use diversity and urban vitality. Results show that four dimensions are associated with urban vitality. Furthermore, the dimensions of the taxi flow density and the road density in low vitality blocks can be distinguishable from other blocks. Results showed a stronger relationship between land-use diversity and urban vitality. The urban expansion direction of Xiamen Island is from the old town around the Xiamen Port to the new district around Yundang Lake to form a continuous covered area, which significantly impacts urban vitality. The approach of this study not only measures urban vitality through human activity but also sheds light on guidelines for sustainable urban development, which can plan and policy in practice for cities in China and many other countries.
H2O2/pH Dual-Responsive Biomimetic Nanoenzyme Drugs Delivery System for Enhanced Tumor Photodynamic Therapy
Authors: Li Xinyuan , Ji Qing , Yan Chao , Zhu Ziyu , Yan Zhihui , Chen Ping , Wang Yisen , Song Li
Published: October 2022

Phototherapy has been recognized as a photochemical process to treat tumor via induce cancer cells necrosis and death, with minimal invasiveness, higher selectivity, and few side effects. However, the therapy effects of phototherapy are often compromised by the hypoxia, high levels of hydrogen peroxide, and glutathione of tumor microenvironment (TME). Therefore, we constructed a catalase-like activity bionic metal–organic framework drugs delivery system (FA-EM@MnO2/ZIF-8/ICG) with tumor microenvironment controllable releasing. In this system, photosensitizer indocyanine green (ICG) was introduced into zeolite imidazole salt skeleton 8 (ZIF-8) by one-step methods, forming ZIF-8/ICG nano-platform, which can effectively avoid ICG-induced phototoxicity and aggregation-induced quenching during transport. MnO2 with catalase-like activity was coated on the surface of ZIF-8/ICG nano-platform, which made it have the ability of self-supplying O2 under the condition of H2O2 in TME. Exposure under near-infrared light can alleviate the anoxic TME, thus improving the phototherapy efficiency. In addition, folate-functionalized erythrocyte membrane is coated on the surface of MnO2/ZIF-8/ICG, which can endow FA-EM@MnO2/ZIF-8/ICG with the ability of targeted drug administration and immune elimination avoidance. Therefore, FA-EM@MnO2/ZIF-8/ICG nano-platform has the catalase-like activity, which can alleviate the oxidative stress state of TME and provide a beneficial environment for photodynamic therapy of tumor.
Assessment of the 2021 summer flood in Central Europe
Authors: Lehmkuhl Frank , Schüttrumpf Holger , Schwarzbauer Jan , Brüll Catrina , Dietze Michael , Letmathe Peter , Völker Carolin , Hollert Henner
Published: October 2022

The flood event in July 2021 in the uplands of the Eifel-Ardennes mountains in Germany, Belgium and The Netherlands and their foreland was caused by heavy rainfall and resulted in one of the largest flood disasters in Western Europe for decades. Due to climate change, it can be assumed that such events will become more frequent in future. Even though such extreme flood can happen at any time, the consequences and impacts can be significantly reduced by appropriate technical and non-technical measures. However, such measures always require a comprehensive understanding and knowledge of previous events and comparable processes. Therefore, this special issue aims at collecting the scientific evaluation and its implications of the 2021 extreme summer flood. This editorial serves as an introduction for an article collection published in the journal Environmental Sciences Europe, providing an overview of the current state of integrative assessment of the 2021 summer flood in Central Europe.
Facile approach for surfactant-free synthesis of Au@ginsenoside Rh2 nanoparticles and researches on anticancer activity
Authors: Yao Hua , Mu Xupeng , Wei Zhenhong , Li Xiuying , Wu Liya , Jin Yongri , Li Xuwen , Li Jing , Jiang Jinlan
Published: October 2022

Background

Inorganic nanocomposites especially Au nanostructures have exhibited outstanding physicochemical properties in biomedical fields. For further clinical applications on theranostics, especially drug delivery, numerous explorations of green and facile synthesis methods combining with pharmacoactive natural components have been investigated to construct safe and multifunctional bioactive Au nanoparticles (NPs). Ginsenoside Rh2 is protopanaxadiol type compound isolated from plants of genus Panax, with excellent anticancer effect and antioxidant activity. In this research, we prepared the novel Au nanoparticles using ginsenoside Rh2 as both reducing and stabilizing agents.

Results

The synthesized Au@ginsenoside Rh2 NPs were proved to exhibit desirable inhibitory effect on different cancer cell lines, which benefited from the inherent anticancer effect of the ginsenoside Rh2. Investigations in vitro indicated that Au@ginsenoside Rh2 NPs inhibited cell proliferation, cell migration and invasion, induced cell cycle arrest, enhanced the reactive oxygen species (ROS) generation, and regulated the protein expressions of caspase-3, 8, 9 to trigger cell apoptosis as well.

Conclusions

Because of the absence of toxic chemical surfactants, the eco-friendly synthesis method of Au NPs modified by natural phytochemicals avoided tedious separation and modification processes. On the other hand, Au@ginsenoside Rh2 NPs also improved water solubility and bioavailability of the hydrophobic drug ginsenoside Rh2. It broadened minds for preparation and application of traditional Chinese medicines (TCMs) modified metal nanoparticles and deserved further study.
The short-term efficacy of high flow nasal oxygen therapy on cardiovascular surgical patients: a randomized crossover trial
Authors: Shiho Deguchi , Kusaka Yusuke , Nakano Shoko , Umegaki Osamu
Published: October 2022

Background

Oxygen therapy after extubation in the intensive care unit (ICU) is essential in order to maintain adequate oxygenation, especially in patients who have undertaken cardiovascular surgery. A Venturi mask (VM) has been routinely used as an oxygen therapy in the ICU. Recently, however, the high flow nasal cannula (HFNC) has become available, and this device can deliver up to 60 L/min of humidified oxygen. The aim of this study is to evaluate the short-term efficacy between HFNC and VM in cardiovascular surgical patients.

Methods

Forty patients who underwent cardiovascular surgery were randomized to either protocol A (HFNC followed by VM) or protocol B (VM followed by HFNC). After 60-minutes of use with either device, arterial blood gas analysis was performed, and the PaO2/FiO2 ratio (PFR) was calculated. Simultaneously, physiological data (respiratory rate, heart rate, mean arterial pressure, continuous cardiac index, and mixed venous oxygen saturation) were recorded. During this procedure, FiO2 and gas flow were maintained at a fixed rate. These variables were compared by using the paired t-test, and a p value < 0.05 was considered significant. All data were expressed as mean (standard deviation).

Results

Thirty-five patients (17 from protocol A and 18 from protocol B) were enrolled, and 5 patients were excluded from analysis in accordance with the exit criteria. PaO2 was significantly higher in the HFNC group than in the VM group [101.7 (25.9) vs. 91.8 (23.0), mean difference 9.87 (18.5), 95% confidence interval 3.5 to 16.2, p = 0.003]. Moreover, PFR was significantly higher in the HFNC group than in the VM group [265.9 (81.4) vs. 238.7 (68.5), p = 0.002]. Moreover, PaCO2 was significantly lower in the HFNC group than in the VM group [33.8 (3.5) vs. 34.7 (2.9), p = 0.033]. The respiratory rate was significantly lower in the HFNC group than in the VM group [18 (4) vs. 21 (4), p = 0.006], and no significant differences were seen in any of the other parameters.

Conclusions

Compared to VM, HFNC ameliorated oxygenation function and decreased patients’ effort in breathing. The hemodynamic state did not differ between HFNC and VM. Therefore, HFNC can be used safely in cardiovascular surgical patients.

Trial registration

This trial was registered with the UMIN Clinical Trials Registry (ID UMIN000016572).
Medical specialists’ attitudes and practices towards childhood vaccination: a qualitative study in Armenia
Authors: Jackson Cath , Nielsen Siff Malue , Simonyan Brigida , Kirakosyan Marine , Hovhannisyan Marine , Sahakyan Gayane , Habersaat Katrine Bach
Published: October 2022

Background

Childhood vaccination rates in Armenia are high. However, anecdotal evidence suggests that some health workers may advise against vaccination. The extent and reasons behind this are unknown. This study used the World Health Organization Tailoring Immunization Programmes approach to investigate medical specialists’ vaccination practices.

Methods

Face-to-face interviews were conducted with 30 medical specialists (paediatricians, immunologists, neonatologists, neurologists, gynaecologists). Interviews explored their vaccination practices (recommending/administering), knowledge, attitudes and confidence. Data were analysed using the Framework approach and COM (Capability, Opportunity, Motivation) factors.

Findings

Medical specialists were routinely consulted by parents about vaccination. They engaged in conversations, even if they did not administer vaccinations and lacked expertise. Vaccination recommendation was “selective”, influenced by their own vaccine hesitancy. Doctors administering vaccination used false contraindications to postpone vaccination. Multiple barriers and drivers to positive vaccination practices were evident, with differences between specialists administering/not administering vaccinations.

Capability

Drivers were knowledge of vaccination, vaccines, and vaccine-preventable diseases; with awareness and use of protocols for adverse events and contraindications (those with a vaccination role). Barriers were a lack of a detailed understanding of vaccination, vaccines, and vaccine-preventable diseases, especially amongst neonatologists and gynaecologists, and for HPV. Poor knowledge of adverse events and mixed knowledge of contraindications was evident, as was low confidence about conversations with parents declining vaccination.

Opportunity

Drivers were using “official“ guidance and professional information and feeling protected by the Government of Armenia should an adverse event occur. Conversely, barriers were a reliance on media/social media without considering credibility, peers not recommending vaccination, increasing parent demands and not feeling protected by the Government.

Motivation

Drivers were seeing vaccination as their responsibility (those who administer vaccinations); and generally supporting vaccination. Barriers were vaccine hesitancy, some anti-vaccination sentiments amongst neonatologists and gynaecologists and not seeing vaccination as their role (those who do not administer vaccinations).

Conclusions

Applying a theory-informed approach allowed us to identify critical issues and possible solutions. High vaccination coverage may disguise underlying issues, e.g. false contraindications. We addressed gaps in the literature, with our geographical focus and study of medical specialists advising parents on vaccination, a widely used practice in this sub-region.
Effects of a targeted resistance intervention compared to a sham intervention on gluteal muscle hypertrophy, fatty infiltration and strength in people with hip osteoarthritis: analysis of secondary outcomes from a randomised clinical trial
Authors: Rostron Zachary P. J. , Zacharias Anita , Semciw Adam I. , Kingsley Michael , Pizzari Tania , Woodley Stephanie J. , Green Rodney
Published: October 2022

Background

People with hip osteoarthritis are typically offered a combination of education and exercise to address muscle atrophy and weakness. Limited evidence exists to assess the efficacy of exercise programs on muscle structure or function in this population. The aim of this study was to evaluate the effects of targeted resistance exercise on gluteal muscle hypertrophy and strength in people with mild-to-moderate hip osteoarthritis.

Methods

Twenty-seven participants with radiologically confirmed hip osteoarthritis recruited from a single site of a multi-site, double-blind clinical trial were randomly allocated to receive a 12-week targeted gluteal intervention or sham intervention. Magnetic resonance imaging and hand-held dynamometry were used to determine change in gluteal muscle volume, fatty infiltration and hip muscle strength. For gluteal muscle volume and strength outcomes mixed model analyses of variance (ANOVA) were conducted. A general linear model (ANOVA) analysis with fixed effects parameter estimates was used to assess the impact of sex on gluteal muscle size and strength of the affected limb only. For muscle fat index a mixed method ANOVA was used to assess the differences between groups and over time.

Results

In the targeted intervention group, gluteus minimus volume increased from baseline to post-intervention in both limbs (pooled mean difference: 0.06 cm3/kg, 95% confidence interval: 0.01 to 0.11) while no change occurred in the sham group (time x group effect: P = 0.025). Gluteus medius, gluteus maximus and tensor fascia lata volume did not change significantly over time. Hip strength (abduction, adduction, flexion, extension, external and internal rotation) improved similarly in both groups (time main effect: P ≤ 0.042). There was a consistent, albeit non-significant, pattern of reduced fatty infiltration after the targeted intervention.

Conclusion

Targeted resistance exercise resulted in gluteus minimus hypertrophy, but improvements in hip strength occurred in both groups. Clinicians delivering hip osteoarthritis rehabilitation programs might consider implementing a targeted exercise program to attenuate disease associated changes within gluteal muscles.

Trial registration

Australian New Zealand Clinical Trials Registry, ID: ACTRN12617000970347. Registered prospectively on 5 July 2017.
Advantages of ligating the rectum with gauze pad band in laparoscopic anterior resection of rectal cancer: a propensity score matched analysis
Authors: Liu Yang , Qi Hengduo , Deng Chun , Zhang Zhenyu , Guo Zhi , Li Xiaojun
Published: October 2022

Purpose

It is difficult to maintain sufficient tension throughout laparoscopic anterior resection with total mesorectal excision, which causes a decline in surgical quality. We used a soft, inexpensive gauze pad band pulling the rectal tube to analyze the effect of surgery.

Methods

A gauze pad band was positioned at the proximal of the tumor, followed by fastening the rectal tube and ligating the rectum. 233 patients undergoing laparoscopic anterior resection for mid to low rectal cancer were enrolled between January 2018 and December 2020. After propensity score matching, 63 cases were selected in gauze pad band group and 126 cases were selected in traditional group. The two groups were compared in preoperative, intraoperative, and pathological characteristics.

Results

Compared to traditional group, the median operation duration (203 min vs. 233 min, p < 0.001) and the median intraoperative bleeding (48 ml vs. 67 ml, p < 0.001) were lesser in gauze pad band group. A higher percentage of one cartridge transection of rectum (36/63 vs. 51/126, p = 0.030), shorter length of cartridges used (6.88 ± 1.27 cm vs. 7.28 ± 1.25 cm, p = 0.040), and longer distal resection margin (2.74 ± 0.76 cm vs. 2.16 + 0.68 cm, p < 0.001) were found in the gauze pad band group. The completeness of total mesorectal excision (61/63 vs. 109/126, p = 0.022), harvested lymph nodes (19 vs. 17, p < 0.001) and positive lymph nodes (1 vs. 0, p = 0.046) were higher in gauze pad band group.

Conclusion

Ligation of the rectum with a gauze pad band allows for a reduction in operative time and intraoperative bleeding while increasing the rate of one cartridge transection. It also protected the quality of total mesorectal excision and membrane anatomy.

Trial registration: Not applicable.
Elevation of serum interleukin-1β levels as a potential indicator for malarial infection and severe malaria: a meta-analysis
Authors: Mahittikorn Aongart , Kwankaew Pattamaporn , Rattaprasert Pongruj , Kotepui Kwuntida Uthaisar , Masangkay Frederick Ramirez , Kotepui Manas
Published: October 2022

Background

Interleukin (IL)-1β is a proinflammatory cytokine that has a role in disease-related inflammation, including malaria. However, reports on the effect of IL-1β on malaria severity are inconsistent. Therefore, meta-analyses to compare differences in IL-1β levels between patients with severe malaria, patients with uncomplicated malaria and healthy controls were performed.

Methods

The PRISMA standards were used to perform a systematic review and meta-analysis. A search of PubMed, Scopus, EMBASE and reference lists was conducted for articles providing data on IL-1β levels between patients with severe malaria, patients with uncomplicated malaria and healthy controls between January 1988 and March 2022, using a combination of search terms. The quality of all studies included in this review was determined using the Strengthening the Reporting of Observational Studies in Epidemiology statement: guidelines for reporting observational studies. The evidence was synthesized quantitatively and qualitatively. The differences in IL-1 levels across participant groups were recounted narratively for qualitative synthesis. For quantitative synthesis, the mean difference in IL-1β levels across groups of participants was calculated using a random effects meta-analysis. The publication bias was assessed using funnel plots, Egger’s test and a contour-enhanced funnel plot.

Results

A total of 1281 articles were discovered, and the 17 that satisfied the inclusion criteria were included for syntheses. The meta-analysis results using data from 555 cases of severe malaria and 1059 cases of uncomplicated malaria showed that severe malaria had a higher mean of IL-1β levels than uncomplicated malaria (P < 0.01, pooled mean difference: 1.92 pg/mL, 95% confidence interval: 0.60–3.25 pg/mL,I2: 90.41%, 6 studies). The meta-analysis results using data from 542 cases of uncomplicated malaria and 455 healthy controls showed no difference in mean IL-1β levels between the two groups (P = 0.07, pooled mean difference: 1.42 pg/mL, 95% confidence interval: − 0.1–2.94 pg/mL,I2: 98.93%, 6 studies).

Conclusion

The results from the meta-analysis revealed that IL-1β levels were higher in patients with severe malaria than in patients with uncomplicated malaria; however, IL-1β levels were similar in patients with uncomplicated malaria and healthy controls. Based on the limitations of the number of studies included in the meta-analysis and high levels of heterogeneity, further studies are needed to conclude that differences in IL-1β levels can be useful for monitoring the malaria severity.
Comprehensive bibliometric and visualized analysis of research on fecal microbial transplantation published from 2000 to 2021
Authors: Ma Jing , Chen Ting , Ma Xiangxue , Zhang Beihua , Zhang Jiaqi , Xu Lin , Wang Yifan , Huang Jinke , Liu Zhihong , Wang Fengyun , Tang Xudong
Published: October 2022

Background

Fecal microbial transplantation has emerged in recent years as a method of treating disease by rebuilding the intestinal flora. However, few bibliometric analyses have systematically studied this area of research. We aimed to use bibliometric analysis to visualize trends and topical research in fecal microbial transplantation to help provide insight into future trends in clinical and basic research.

Materials and methods

Articles and reviews related to fecal microbial transplantation were collected from the Web of Science Core Collection. Significant information associated with this field was visually analyzed by using Biblioshiny and CtieSpace software.

Results

A total of 3144 articles and overviews were included. The number of publications related to fecal microbial transplantation significantly increased yearly. These publications mainly came from 100 countries, led by the US and China, and 521 institutions. The most prolific and influential author is KHORUTS A. The main disciplines and application fields of fecal microbial transplantation included molecular /biology/immunology and medicine/clinical medicine, and the research foundation of fecal microbial transplantation was molecular /biology/genetics and health/nursing/medicine. An alluvial flow visualization showed several landmark articles. New developments were identified in terms of reference and keyword citation bursts. Data analysis showed that different FMT preparation and delivery methods gradually appeared as research hotspots. The main research keywords in the last 3 years were chain fatty acids, Akkermansia muciniphila, and insulin sensitivity, other keywords were current and developing research fields.

Conclusion

Research on fecal microbial transplantation is flourishing and many new applications of fecal microbial transplantation are emerging. Microbial metabolites such as short-chain fatty acids and the microbiota–gut–brain axis have become the focus of current research and are future research trends.
m6A-immune-related lncRNA prognostic signature for predicting immune landscape and prognosis of bladder cancer
Authors: Feng Zi-Hao , Liang Yan-Ping , Cen Jun-Jie , Yao Hao-Hua , Lin Hai-Shan , Li Jia-Ying , Liang Hui , Wang Zhu , Deng Qiong , Cao Jia-Zheng , Huang Yong , Wei Jin-Huan , Luo Jun-Hang , Chen Wei , Chen Zhen-Hua
Published: October 2022

Background

N6-methyladenosine (m6A) related long noncoding RNAs (lncRNAs) may have prognostic value in bladder cancer for their key role in tumorigenesis and innate immunity.

Methods

Bladder cancer transcriptome data and the corresponding clinical data were acquired from the Cancer Genome Atlas (TCGA) database. The m6A-immune-related lncRNAs were identified using univariate Cox regression analysis and Pearson correlation analysis. A risk model was established using least absolute shrinkage and selection operator (LASSO) Cox regression analyses, and analyzed using nomogram, time-dependent receiver operating characteristics (ROC) and Kaplan–Meier survival analysis. The differences in infiltration scores, clinical features, and sensitivity to Talazoparib of various immune cells between low- and high-risk groups were investigated.

Results

Totally 618 m6A-immune-related lncRNAs and 490 immune-related lncRNAs were identified from TCGA, and 47 lncRNAs of their intersection demonstrated prognostic values. A risk model with 11 lncRNAs was established by Lasso Cox regression, and can predict the prognosis of bladder cancer patients as demonstrated by time-dependent ROC and Kaplan–Meier analysis. Significant correlations were determined between risk score and tumor malignancy or immune cell infiltration. Meanwhile, significant differences were observed in tumor mutation burden and stemness-score between the low-risk group and high-risk group. Moreover, high-risk group patients were more responsive to Talazoparib.

Conclusions

An m6A-immune-related lncRNA risk model was established in this study, which can be applied to predict prognosis, immune landscape and chemotherapeutic response in bladder cancer.
The updated Consolidated Framework for Implementation Research based on user feedback
Authors: Damschroder Laura J. , Reardon Caitlin M. , Widerquist Marilla A. Opra , Lowery Julie
Published: October 2022

Background

Many implementation efforts fail, even with highly developed plans for execution, because contextual factors can be powerful forces working against implementation in the real world. The Consolidated Framework for Implementation Research (CFIR) is one of the most commonly used determinant frameworks to assess these contextual factors; however, it has been over 10 years since publication and there is a need for updates. The purpose of this project was to elicit feedback from experienced CFIR users to inform updates to the framework.

Methods

User feedback was obtained from two sources: (1) a literature review with a systematic search; and (2) a survey of authors who used the CFIR in a published study. Data were combined across both sources and reviewed to identify themes; a consensus approach was used to finalize all CFIR updates. The VA Ann Arbor Healthcare System IRB declared this study exempt from the requirements of 38 CFR 16 based on category 2.

Results

The systematic search yielded 376 articles that contained the CFIR in the title and/or abstract and 334 unique authors with contact information; 59 articles included feedback on the CFIR. Forty percent (n = 134/334) of authors completed the survey. The CFIR received positive ratings on most framework sensibility items (e.g., applicability, usability), but respondents also provided recommendations for changes. Overall, updates to the CFIR include revisions to existing domains and constructs as well as the addition, removal, or relocation of constructs. These changes address important critiques of the CFIR, including better centering innovation recipients and adding determinants to equity in implementation.

Conclusion

The updates in the CFIR reflect feedback from a growing community of CFIR users. Although there are many updates, constructs can be mapped back to the original CFIR to ensure longitudinal consistency. We encourage users to continue critiquing the CFIR, facilitating the evolution of the framework as implementation science advances.
On a greedy approach for genome scaffolding
Authors: Davot Tom , Chateau Annie , Fossé Rohan , Giroudeau Rodolphe , Weller Mathias
Published: October 2022

Background

Scaffolding is a bioinformatics problem aimed at completing the contig assembly process by determining the relative position and orientation of these contigs. It can be seen as a paths and cycles cover problem of a particular graph called the “scaffold graph”.

Results

We provide some NP-hardness and inapproximability results on this problem. We also adapt a greedy approximation algorithm on complete graphs so that it works on a special class aiming to be close to real instances. The described algorithm is the first polynomial-time approximation algorithm designed for this problem on non-complete graphs.

Conclusion

Tests on a set of simulated instances show that our algorithm provides better results than the version on complete graphs.
Provision of trauma care in asymmetric warfare: a conceptual framework to support the decision to implement frontline care services
Authors: Salio F. , Pirisi A. , Bruni E. , Court M. , Peleg K. , Reaiche S. , Redmond A. , Weinstein E. , Hubloue I. , Corte F. Della , Ragazzoni L.
Published: October 2022

Introduction

The emerging trends of asymmetric and urban warfare call for a revision of the needs and the way in which frontline trauma care is provided to affected population. However, there is no consensus on the process to decide when and how to provide such lifesaving interventions in form of Trauma Stabilization Point (TSP).

Methods

A three-step Delphi method was used to establish consensus. A focus group discussion was convened to propose a framework and develop the list of twenty-one (21) statements for validation of a group of experts.

Results

A panel of twenty-eight (28) experts reviewed the statements and participated to both first and second rounds. Comments and recommendations provided by the FGD and during round 1 were used to analyze the findings of the study. The proposed framework includes five main categories identified as interconnected components that facilitate the decision to implement or not the TSP. A total of sixteen (16) elements distributed across the five categories have been considered as being able to guide the decision to utilize such capability in high-risk security and resource constrained settings.

Conclusion

The TSP has the potential to prevent death and disability. The proposed framework and categories add a structure to the decision-making process and represents an important step to support emergency and trauma care planning and implementation efforts.
Microbial assembly and co-occurrence network in an aquifer under press perturbation
Authors: Abiriga Daniel , Jenkins Andrew , Klempe Harald
Published: October 2022

Purpose

Thousands of aquifers worldwide have been polluted by leachate from landfills and many more remained threatened. Microbial communities from these environments play a crucial role in mediating biodegradation and maintaining the biogeochemical cycles, but their co-occurrence and assembly mechanism have not been investigated.

Method

Here, we coupled network analysis with multivariate statistics to assess the relative importance of deterministic versus stochastic microbial assembly in an aquifer undergoing intrinsic remediation, using 16S metabarcoding data generated through Illumina MiSeq sequencing of the archaeal/bacterial V3–V4 hypervariable region.

Results

Results show that both the aquifer-wide and localised community co-occurrences deviate from expectations under null models, indicating the predominance of deterministic processes in shaping the microbial communities. Further, the amount of variation in the microbial community explained by the measured environmental variables was 55.3%, which illustrates the importance of causal factors in forming the structure of microbial communities in the aquifer. Based on the network topology, several putative keystone taxa were identified which varied remarkably among the wells in terms of their number and composition. They included Nitrospira, Nitrosomonadaceae, Patulibacter, Legionella, uncharacterised Chloroflexi, Vicinamibacteriales, Neisseriaceae, Gemmatimonadaceae, and Steroidobacteraceae. The putative keystone taxa may be providing crucial functions in the aquifer ranging from nitrogen cycling by Nitrospira, Nitrosomonadaceae, and Steroidobacteraceae, to phosphorous bioaccumulation by Gemmatimonadaceae.

Conclusion

Collectively, the findings provide answers to fundamental ecological questions which improve our understanding of the microbial ecology of landfill leachate plumes, an ecosystem that remains understudied.
Association of early dexamethasone therapy with mortality in critically Ill COVID-19 patients: a French multicenter study
Authors: Raymond Matthieu , Le Thuaut Aurélie , Asfar Pierre , Darreau Cédric , Reizine Florian , Colin Gwenhaël , Dano Charly , Lorber Julien , Hourmant Baptiste , Delbove Agathe , Frérou Aurélien , Morin Jean , Egreteau Pierre Yves , Seguin Philippe , Reignier Jean , Lascarrou Jean-Baptiste , Canet Emmanuel
Published: October 2022

Background

Dexamethasone is recommended for COVID-19 patients who require oxygen therapy. However, its effectiveness in reducing mortality and intubation, and its safety, remain debated. We aimed to investigate whether dexamethasone reduces day-28 mortality in unselected patients with critical COVID-19.

Methods

We performed an observational cohort study in consecutive COVID-19 patients admitted to any of 13 French intensive care units (ICUs) in 2020. The primary objective was to determine whether early dexamethasone therapy was associated with day-28 mortality and the secondary objectives were to assess whether early dexamethasone decreased intubation requirements and to collect adverse events.

Results

Of 1058 included patients, 611 (57.75%) received early dexamethasone (early dexamethasone group), 358 (33.83%) did not receive any steroids (no steroids group), and 89 (8.41%) received late dexamethasone or other steroids. Day-28 mortality was similar between the early dexamethasone and the no steroids groups (15.06% and 14.25%, respectively; P = 0.59). Factors associated with day-28 mortality were older age (adjusted hazard ratio [aHR], 1.06; 1.04–1.09; P < 0.001), worse SOFA score (aHR, 1.13; 1.06–1.20; P < 0.001), and immunocompromised status (aHR, 1.59; 1.01–2.50; P = 0.043). Early dexamethasone was associated with fewer intubations (48.55% vs. 61.49%, P < 0.001) and more ventilator-free days by day 28 (22 [2–28] vs. 17 [1–28] days, P = 0.003), compared to no steroids. Ventilator-associated pneumonia (VAP) was more common with early dexamethasone (HR, 1.29 [1.01–1.63], P = 0.04) than with no steroids, whereas no differences were noted for bloodstream infection, fungal infection, or gastrointestinal bleeding.

Conclusions

Early dexamethasone in critically ill COVID-19 patients was not associated with lower day-28 mortality. However, early dexamethasone was associated with lower intubation needs and more ventilator-free days by day 28. In patients treated with invasive mechanical ventilation, early dexamethasone was associated with a higher risk of VAP.