bluuebunny/crossref_metadata_2025 huggingface dataset:
THE TRANSFORMATION OF PESANTREN TAHFIDZ AL QUR’AN EDUCATIONAL MANAGEMENT
Authors: Priyatno Agus
Published: December 2017

The research purpose is to describe the transformation of education management which focus is on memorizing Al Qur’an in Jawa Tengah. The research is qualitative of ethnographic approach to observe the Pesantren Yanbu’ul Qur’an Arwaniyyah Kudus in Central Java which had been conducted in 2016.Data were collected by a series of observations, in-depth interviews and document analysis and archival research. The uniqueness and the consistency in memorizing Al Qur’an can be clearly seen from a series of transformation to the learning system such as its curriculum, methods, materials, teachers, media and evaluation system. Institutional development is in accordance with the type of the Pesantren, education level and management cooperation which expectation is to be able to serve students from a wide segmentation. Predominance leadership style relies on the charismatic Kyai as delegated to the Pesantren institutional unit leadership system and professional assistances.ThePesantren able to manage such transformation without sacrificing the character as a traditional pesantren well known for its special culture as an institution in which knowledge of Islam is transmitted and transferred, Islam values and tradition reservation and ulema reproduction.

Keywords:       Pesantren, Reciter, Tranformation, Education Management
INFLUENCE OF COMPETENCE, TRANSFORMATIONAL LEADERSHIP, SOCIAL CAPITAL AND PERFORMANCE ON EMPLOYEE CAREERS
Authors: Kusuma Wardhani Nia
Published: December 2017

Every employee would expect a career enhancement in his job. There are many factors that affect employee careers. This study aims to examine the influence of Competence, Transformational Leadership, Social Capital and Performance to Career Employees of Mercu Buana University, is a quantitative research with Path Analysis method. This research was conducted at Mercu Buana University in West Jakarta area, the research sample was 185 employees using Simple Random Sampling method. Associated with the performance of employees, the results showed that there is an influence of competence on performance, there is the influence of transformational leadership on performance, there is the influence of social capital on performance. In the case of employee career, the result of research indicate that there is influence of competence to career of employee, there is influence of employee career performance, there is influence of social capital to career of employee. The result of path analysis gives a structural equation Y = 0,258X1 + 0,213X2 + 0,229X3 + 0,416X4 + 0,36. Thus it can be explained that the most direct influence on Employee Career is a Performance variable of 41.6%, while the Competence variable of 25.8% and social capital variable of 22.9%.

Keywords:Competence,Transformational Leadership, Social Capital, Performance,Careers
EVALUATION OF EDUCATION IMPLEMENTATION OF TRAINING PIM III IN AGENCY OF HUMAN RESOURCE DEVELOPMENT
Authors: Sari Kencana , Mukhtar Mukneri , Supriyati Yetti
Published: December 2017

This study is a qualitative research aims to find out how the implementation of leadership level III training at Human Resources Development Board of Province of South Sumatera based on: (1) participant's satisfaction covers: participant's satisfaction to widyaiswara or resource person, participant's satisfaction to organizer committee service, participant's satisfaction on training materials, participant's satisfaction on training schedule, Participants on training facilities and infrastructure, and participant's satisfaction with the training consumption; (2) learning activities include: participant activity in learning process, widyaiswara activity or resource in learning process, and organizer activity of organizer in learning process; (3) changes in the behavior of alumni after returning to their respective duties, including: behavioral changes in implementing management functions, behavior change in task delegation, behavior change in coordination, and behavior change in decision making; (4) Impact of change in employment behavior of alumni to improve agency performance; and (5) Impact of change in work behavior of alumni to improve service quality of institution.

Keywords: Evaluation, Educational, Training and Leaderships.
INHIBITORY POTENCY OF WITHANIA SOMNIFERA EXTRACTS AGAINST DPP-4: AN IN VITRO EVALUATION
Authors: Kempegowda Praveen Kumar , Zameer Farhan , Narasimashetty Chethan Kumar , Kollur Shiva Prasad , Murari Satish Kumar
Published: December 2017

Background: Pharmacologic treatments for type 2 diabetes are based upon increasing insulin availability and improving sensitivity to insulin. Nowadays, glucagon like peptide-1 (GLP-1) based therapies aims at glucose control through DPP-4 inhibitors. DPP-4 is a transmembrane glycoprotein belongs to prolyl oligopeptidase family, with the specificity of removing X-Pro or X-Ala dipeptides from the N-terminus of polypeptides. GLP-1 effect by stimulating glucose-dependent insulin release from the pancreatic islets, inhibit inappropriate post-meal glucagon release and slow gastric emptying promoting leaky gut. The current study investigated DPP-4 inhibitory activity of catechin, isolated from Withania somnifera (WS), for ethnopharmacological treatment of type 2 diabetes and aimed to increase availability of GLP-1and sensitivity to insulin.

Materials and Methods: Young and matured fresh roots, leaves, and fruits of WS plant extract were considered and were systematically evaluated for DPP-4 inhibitory activity using in vitro method, enzyme kinetics, phytochemical analysis, RP-HPLC, LCMS and 1H and 13C NMR method and structure-activity relationship (SAR) studies.

Results: In this study, methanol (100% and 80%) extracts of WS matured root exhibited maximum DPP-4 inhibitory activity when compared to other extracts. The maximum DPP-4 inhibitory activity was found in 100% methanol extract of matured root. Phytobioactive was purified by RP-HPLC. The compound purified was found to be flavonoid and was characterized (LCMS, 1H and 13C NMR studies), identified as catechin. Auxiliary, molecular docking was performed using Ligand Fit method using PatchDock package. The study revealed the binding affinity of catechin with DPP-4 to be -6.601 kcal/mol with 13 hydrogen interactions with the receptor and was very similar to the standard potent blockers withaferin A and others (cuscohygrine, scopoletin, sitoindoside IV, tropine), further confirming its hyperglycemic potency.

Conclusion: The study reveals that, 100% methanol extract of WS matured roots contains the compound- catechin, which exhibits DPP-4 inhibitory activity resulting in increased level of bioactive GLP-1 and GIP. In this background, we concluded that the WS will be a better source for further development as new antidiabetic drugs.
JOB RESOURCES AS A MEDIATOR BETWEEN MANAGEMENT TRUST CLIMATE AND EMPLOYEES’ WELL-BEING: A CROSS-SECTIONAL MULTILEVEL APPROACH
Authors: Michelle Lee Chin Chin  , Mohd Awang Idris
Published: December 2017

Adopting the notion that environmental factors affect employees, we investigated the importance of management trust climate as a precursor to job resources (i.e., personal development), positive work outcomes (engagement and job performance) and better well-being (i.e., avoidance of burnout and sleeping problems). Because the Malaysian society is considered to have a higher level of trust than other Asian countries, we used a snowball sampling method and recruited 377 employees from 44 private organisations (62% response rate) in Malaysia as participants in the current study. Multilevel analyses revealed that management trust climate led to higher levels of personal development and job performance; however, it showed no relation to sleeping problems. In addition, personal development mediated management trust climate and job performance, whereas engagement mediated personal development and job performance. Higher burnout led to increased sleeping problems. This study showed organisational level to be an antecedent of job resources and its job resource-engagement model. Since trust conveys a soft psychological contract between two parties, organisations should be aware of the ways trust can be cultivated within the organisation, such as by allowing employees to grow and develop their skills. This may be an effective strategy for ensuring that employees are able to grow within their organisations and execute their duties effectively, without reprisals from higher management.
O GESTO PARTICULAR E A FEBRE DO MUNDO:	UM ENSAIO SOBRE A AMBIVALENTE CONFLUÊNCIA DO CONSUMO SUSTENTÁVEL E AS MUDANÇAS DO CLIMA
Authors: Efing Antônio Carlos , Maganhati Mendes Rullyan Levi
Published: December 2017

O presente estudo tem por objetivo contextualizar o consumo sustentável a partir de um de seus motes argumentativos mais recentes, o das mudanças do clima. Na persecução de um desenvolvimento sustentável e, por consequência, de um consumo com ele compatível, o nexo clima-consumo foi internalizado no discurso do poder público, da iniciativa privada e do terceiro setor. Contudo, o sentido geral de consumo sustentável atualmente oferecido revela-se ambivalente, servindo, em certa medida, como reforço aos níveis de consumo já praticados.
Desenvolvimento Econômico e Social por meio de Investimentos em Infraestrutura: O Caso da BR-163
Authors: Rocha Fernando Vinícius da , Saes Maria Sylvia Macchione
Published: December 2017

A infraestrutura logística é essencial para o desenvolvimento econômico. Diversos trabalhos evidenciam os problemas de infraestrutura existente no Brasil, devido ao baixo nível de investimento por parte do Estado e do setor privado, que geram ineficiências em diversos setores produtivos da economia. Inserido nessa temática este artigo analisa o desenvolvimento econômico e social como consequências dos investimentos em infraestrutura de transporte. Especificamente, o artigo analisa os efeitos da rodovia BR-163 no Índice de Desenvolvimento Econômico (IDH) dos municípios nos estados do Mato Grosso (MT) e Pará (PA). Em termos metodológicos, o Propensity Score Matching (PSM) foi a técnica estatística utilizada, a qual, através de comparativos entre os municípios, estima o efeito médio da presença da rodovia. Os resultados alcançados mostram efeito positivo dos investimentos em infraestrutura logística no desenvolvimento econômico e social. Os municípios mato-grossenses e paraenses localizados no entorno dessa rodovia apresenta IDH superior em relação aos demais municípios comparáveis. As conclusões destacam a importância do aperfeiçoamento das políticas públicas que visam promover o desenvolvimento econômico a partir de investimentos em infraestrutura no Brasil.
Comparison of three types of anaerobic granular sludge for treating pharmaceutical wastewater
Authors: Wang Yibo , Feng Minquan , Liu Yonghong , Li Yaozhong , Zhang Bofei
Published: December 2017

Three types of anaerobic granular sludge for treating chemical synthesis-based pharmaceutical wastewater were compared: (1) an up-flow anaerobic sludge blanket (UASB) filled with polyvinyl alcohol (PVA) gel beads (UASB-PVA); (2) a UASB filled with traditional anaerobic granular sludge; and (3) a UASB filled with traditional anaerobic granular sludge and granular active carbon (UASB-GAC). The domestication times for the UASB-PVA, UASB, and UASB-GAC reactors were 30, 47, and 47 days, respectively. When the organic loading rate (OLR) was up to 7 kg chemical oxygen demand (COD)/(m3·d), the COD efficiency of the UASB-PVA, UASB, and UASB-GAC stayed in the range of 69% to 75% (deviation 1.8%), 46% to 69% (deviation 8.6%), and 61% to 73% (deviation 4.0%), respectively. The highest OLRs reached for the UASB-PVA, UASB, and UASB-GAC were 12, 7, and 8 kg COD/(m3·d), respectively. The performance of the UASB-PVA was the best of the three, the UASB-GAC was second, and the UASB was the worst. High-throughput pyrosequencing analysis showed that Levilinea, Syntrophorhabdus, Desulfovibrio and Acetobacterium were the dominant bacteria in the UASB-PVA, UASB, and UASB-GAC reactors’ granular sludge. The abundance and diversity of the microbial community in the UASB-PVA sludge were higher than for the UASB and UASB-GAC granular sludge.
Enhanced adsorption of ciprofloxacin by KOH modified biochar derived from potato stems and leaves
Authors: Li Ruining , Wang Zhaowei , Guo Jialei , Li Yan , Zhang Hanyu , Zhu Junmin , Xie Xiaoyun
Published: December 2017

Potato stems and leaves biochar (PB) was prepared by pyrolysis at a temperature of 500°C under anoxic conditions. In order to strengthen the adsorption capacity, biochar was modified with alkaline solution (alkali modified biochar, APB). Two kinds of biochars were adopted as adsorbents to remove ciprofloxacin (CIP) from aqueous solution. The adsorption behavior of CIP onto biochar before and after alkali modified including adsorption kinetics and isotherms were investigated. The effects of different factors (equilibrium time, pH, temperature and initial concentration) during the adsorption process were also investigated. Biochar samples were characterized by Fourier transform infrared (FTIR), scanning electron microscopy (SEM), and nitrogen adsorption–desorption isotherm. The results showed that the alkali treated biochar possessed more mesopores than raw biochar, and accordingly exhibited a more excellent adsorption performance (23.36 mg·g−1) than raw biochar. Hydrophobic interaction, hydrogen-bonding interaction, electrostatic interaction, and π − π interaction were the adsorption mechanisms for CIP uptake onto the two adsorbents.
Micropollutant removal from black water and grey water sludge in a UASB-GAC reactor
Authors: Butkovskyi A. , Sevenou L. , Meulepas R. J. W. , Hernandez Leal L. , Zeeman G. , Rijnaarts H. H. M.
Published: December 2017

The effect of granular activated carbon (GAC) addition on the removal of diclofenac, ibuprofen, metoprolol, galaxolide and triclosan in a up-flow anaerobic sludge blanket (UASB) reactor was studied. Prior to the reactor studies, batch experiments indicated that addition of activated carbon to UASB sludge can decrease micropollutant concentrations in both liquid phase and sludge. In continuous experiments, two UASB reactors were operated for 260 days at an HRT of 20 days, using a mixture of source separated black water and sludge from aerobic grey water treatment as influent. GAC (5.7 g per liter of reactor volume) was added to one of the reactors on day 138. No significant difference in COD removal and biogas production between reactors with and without GAC addition was observed. In the presence of GAC, fewer micropollutants were washed out with the effluent and a lower accumulation of micropollutants in sludge and particulate organic matter occurred, which is an advantage in micropollutant emission reduction from wastewater. However, the removal of micropollutants by adding GAC to a UASB reactor would require more activated carbon compared to effluent post-treatment. Additional research is needed to estimate the effect of bioregeneration on the lifetime of activated carbon in a UASB-GAC reactor.
Removal of antibiotic resistant E. coli in two Norwegian wastewater treatment plants and by nano- and ultra-filtration processes
Authors: Schwermer Carsten Ulrich , Krzeminski Pawel , Wennberg Aina Charlotte , Vogelsang Christian , Uhl Wolfgang
Published: December 2017

The effectivity of different treatment stages at two large wastewater treatment plants (WWTPs) located in Oslo, Norway, to remove antibiotic resistant Escherichia coli from municipal wastewater was investigated. The WWTPs were effective in reducing the total cultivable E. coli. The E. coli in WWTP samples were mainly resistant to ampicillin (6–27%) and trimethoprim-sulfamethoxazole (5–24%), and, to a lesser extent, tetracycline (3–14%) and ciprofloxacin (0–7%). In the first WWTP, a clear decrease in the percentage of E. coli resistant to these antibiotics was found, with the main removal occurring during physical/chemical treatment. In the second WWTP, the percentage of cultivable resistant E. coli did not display a considerable change. During laboratory-scale membrane filtration of WWTP effluents using ultrafiltration (UF) and nanofiltration (NF) membranes, all E. coli, including those resistant to antibiotics, were removed completely. The results imply that UF and NF processes are potent measures to remove antibiotic resistant bacteria (ARB) during post-treatment of WWTP effluents, thus reducing the potential spread of antibiotic resistance in the receiving aquatic environment.
The Interplay between G-quadruplex and Transcription
Authors: Kim Nayun
Published: December 2017

G4 DNA is a non-canonical DNA structure consisting of a stacked array of Gquartets held together by base pairing between guanine bases. The formation of G4 DNA requires a cluster of guanine-runs within a strand of DNA. Even though the chemistry of this remarkable DNA structure has been under investigation for decades, evidence supporting the biological relevance of G4 DNA has only begun to emerge and point to very important and conserved biological functions. This review will specifically focus on the interplay between transcription and G4 DNA and discuss two alternative but interconnected perspectives. The first part of the review will describe the evidence substantiating the intriguing idea that a shift in DNA structural conformation could be another layer of non-genetic or epigenetic regulator of gene expression and thereby an important determinant of cell fate. The second part will describe the recent genetic studies showing that those genomic loci containing G4 DNA-forming guanine-rich sequences are potential hotspots of genome instability and that the level and orientation of transcription is critical in the materialization of genome instability associated with these sequences.
Thrombolytic Therapy in the Current ERA: Myocardial Infarction and Beyond
Authors: Proctor Patrick , Leesar Massoud A. , Chatterjee Arka
Published: December 2017

Thrombolytic therapy kick-started the era of modern cardiology but in the last few decades it has been
largely supplanted by primary percutaneous coronary intervention (PCI) as the go-to treatment for acute myocardial
infarction. However, these agents remain important for vast populations without access to primary PCI and
acute ischemic stroke. More innovative uses have recently come up for the treatment of a variety of conditions.
This article summarizes the history, evidence base and current use of thrombolytics in cardiovascular disease.
Drug-Coated Balloons Applications in Interventional Cardiology
Authors: Rigatelli Gianluca , Zuin Marco
Published: December 2017

Backgrounds: Drug coated balloons (DCBs) are new on stented-based anti-proliferative drug delivery
systems, recently introduced in interventional cardiology. Their primary aim is to transfer an anti-proliferative
drug to reduce the subsequent neo-intima hyperplasia and to maintain the normal vessel diameter and function.

Methods:

A review of the most recent influential studies about DCBs in all the fields of interventional cardiology
has been performed.

Results:

As demonstrated by different studies, DCBs have different theoretical advantages over Drug Eluting
Stents (DESs), especially for the treatment of some endovascular lesions, as In-Stent Restenosis (ISR), coronary
bifurcations, small vessels disease and peripheral artery disease at femoropopliteal and below the knee sites.

Conclusion:

Despite the need of further studies are needed to elucidate the optimal use of DCBs their current use
in interventional cardiology appears promising.
Glucose-lowering Strategies in Diabetes: Pharmacological Development of New Antidiabetic Drugs
Authors: Schwartsburd Polina
Published: December 2017

Background:

Insulin increases glucose uptake in muscles and fat and inhibits hepatic glucose production,
thus serving as the primary regulator of the blood glucose level. In type 2 diabetes, insufficient insulin release
and suppressed insulin action [named insulin resistance] lead to increased glucose production in liver and
decreased glucose uptake by muscles and fat tissues, resulting in elevated blood glucose concentration which is
dangerous to human health. Therefore, the anti-diabetic therapies are aimed at inhibiting excess blood glucose.

Methods:

A comparative analysis of two distinct glucose-lowering modes was used to develop a new feedback
model for the purpose of identification of pharmacological targets in diabetes treatment.

Results:

The current brief opinion proposes an original feedback control of glucose-lowering regulation and its
models which allow comparing two distinct strategies of glucose level correction, i.e., one of them allows reducing
the increased threshold of insulin resistance, whereas the other allows overcoming this threshold/barrier using
exogenous insulin treatment. Also, this analytic research presents selected examples comparing the influence of
the two analyzed strategies on the normalization of glucose metabolism, their therapeutic potential and side effects
associated with additional weight gain. These models show the pathological mechanism by which exogenous
insulin provokes formation of a «vicious cycle» by its side effects associated with additional weight gain.

Conclusion:

The presented model and findings can contribute to the development of new anti-diabetic targets and
drugs with minimal side effects.
Onset of Hypertension in Leflunamide Treated Low Socioeconomic Rheumatoid Arthritis Patients: An Unseen Iceberg
Authors: Ishaq Muhammad , Razzaque Salma , Shohail Fadieleh , Kumar Ajeet , Muhammad Jibran Sualeh
Published: December 2017

Objective:

To determine the frequency of new-onset hypertension in patients with
Rheumatoid arthritis taking leflunomide, in comparison with methotrexate in Asian setting.

Material and Methods:

Perspective case-control study was conducted in 2014 in a tertiary care
hospital located in Karachi, Pakistan. Adult patients, having rheumatoid arthritis were randomly
prescribed leflunomide or methotrexate. Patients having chronic hypertension, proteinuria and
chronic kidney disease were excluded. Patients were monthly followed for blood pressure and heart
rate measurements. Hypertension was defined using JNC 7 criteria.

Results:

Out of 144 patients enrolled, 80 patients received Leflunomide while 64 were started on
methotrexate. Mean systolic blood pressure in leflunomide group at the start and at the end of study
was 108.5 and 135.4mmHg, respectively while in methotrexate group, mean systolic BP was 109.8
and 110.5 mmhg, respectively. After one year follow up, 33 out of 80 (41%) patients were receiving
leflunomide had pre-hypertension or hypertension, while only 3 out of 64 patients (4.7%) were
receiving methotrexate had hypertension.

Conclusion:

Risk of developing hypertension in patient receiving Leflunomide is much higher in
Asian population like Pakistan as compared to western population.
Genetic Susceptibility in Family Members of Egyptian Hepatitis C Virus Infected Patients: Role of Interleukin-12 B Gene Polymorphism
Authors: Elwan Nadia , Elwan Nadia , Assal Fathia , Assal Fathia , Elfert Asem , Elfert Asem , AboAli Lobna , AboAli Lobna , Soliman Shaimaa , Soliman Shaimaa , Soliman Samah , Soliman Samah , Elkhalawany Walaa , Elkhalawany Walaa , Badawy Rehab , Badawy Rehab , Effat Laila , Effat Laila , Sayed Khalda , Sayed Khalda , Shalaby Safinaz , Shalaby Safinaz , Shehab Marwa , Shehab Marwa , Abdel-Hamid Mohamed , Abdel-Hamid Mohamed , Abd-Elsalam Sherief , Abd-Elsalam Sherief
Published: December 2017

Aim:

The research was conducted to study 1188 AC polymorphism of Interleukin
(IL)-12B gene for C/C, A/C and A/A genotypes in families of Hepatitis C virus
(HCV) infected patients in Egypt.

Methods:

Three hundreds HCV patients, 860 family members and 100 healthy subjects
were studied. All family members were screened for HCV antibodies by enzyme-linked
immunosorbent assay (ELISA). Positive cases were examined using Real-Time polymerase
chain reaction (PCR) to confirm the presence of HCV ribonucleic acid (RNA) and detect
the viral load. Molecular study of IL-12B gene was carried out on all patients, family
members and controls using PCR and restriction enzyme analysis.

Results:

HCV infection was confirmed in 10.6% of family members. The distribution of
IL-12B gene polymorphism in patients was 2.3%, 45.7% and 52% for C/C, A/C and A/A
genotypes respectively, in infected family members was 3.3%, 41.7%, 55%, in noninfected
family members was 4.5%, 43.5% and 52% for C/C, A/C and A/A genotypes respectively
and in control was 5%, 36% and 59% for C/C, A/C and A/A genotypes respectively.
The frequency of the C/C, A/C and A/A genotype was not significantly different
between the studied groups.

Conclusion:

IL-12B gene polymorphism has no role in intrafamilial susceptibility of
HCV transmission. The distribution of the functional 1188 AC polymorphism of Interleukin
(IL)-12B gene for C/C, A/C and A/A genotypes was not significantly different
among the studied groups.
Pengaruh Sistem Lantai dan Tingkat Kepadatan Kandang Terhadap Performance Produksi Ayam Arab Jantan Periode Grower
Authors: Putri Ajeng Megawati , Muharlien Muharlien , Nursita Ita Wahju
Published: December 2017

The purpose of this study was to determine the effect of litter system and interaction of both different level of cage density grower arab chicken. The material used were 48 arabic chicken at grower period which the age 2 months and the average weight 701.7Â±94.37 gÂ  and the value SD 13.45%. The method used in this study was experimented with completely randomized design (CRD) factorial patterns. First factor was litter systemÂ  danÂ  second factor was the level of cage density. Data were analyzed by analysis of variance (ANOVA) , if there was different followed by duncan multiple range test. The results showed that litter system of cage was not showed any significant effect (P>0.05) on feed consumption, weight growth andÂ  feed conversion. The level of cage density was gave significant different (P<0.01) on feed consumption, weight growth and feed conversion. Interaction between litter system and different level of cage density were not gave significant effect (P>0.05). The conclusion of this study there was not interaction between factor litter system and the level of cage density.
Pemanfaatan Rebusan Daun Sirih Merah (Piper crocatum) Dalam Menurunkan Tingkat Kejadian Mastitis Berdasarkann Uji CMT dan SCC
Authors: Sjuhada Razan Harastha , Surjowardojo Puguh , Setyowati Endang
Published: December 2017

The red betel leaves (Piper crocatum) known as herbal antiseptic that contain many substances like essential oil, flavonoid, saponin, and tannin. The red betel leaves can be use to replace chemical antiseptic and more safe to use for teat dipping for dairy cow. The purpose of this research was to determine the effect of teat dipping with red betel leaves decoction to decrease subclinical mastitis level and somatic cell based on CMT and SCC. The method in this research was experiment with Randomize Block Design with 3 treatments and 5 replications. The data analyzed with Analysis of Variance (ANOVA), if there were significant effects it would be continue by Duncanâ€™s Multiple Range Test (DMRT). The results showed that teat dipping with red betel leaves decoction had a significant different (P<0.05) to decrease mastitis level. Teat dipping with red betel leaves decoction 20% concentration could decrease mastitis level up to 30%. Teat dipping with red betel leaves decoction had a significant difference (P<0.05) to decrease the amount of somatic cell too. Teat dipping with red betel leaves stew 20% concentration could decrease the amount of somatic cell up to 1.98% or 0.12CFU/ml. The conclusion that teat dipping with red betel leaves decoction 20% was the best concentration and gave the best results to decrease mastitis level and somatic cell.
Uptake and Scalability of a Peritoneal Dialysis Virtual Care Solution: Qualitative Study (Preprint)
Authors: Jeffs Lianne , Jamieson Trevor , Saragosa Marianne , Mukerji Geetha , Jain Arsh K , Man Rachel , Desveaux Laura , Shaw James , Agarwal Payal , Hensel Jennifer M , Maione Maria , Onabajo Nike , Nguyen Megan , Bhatia R
Published: December 2017

BACKGROUND

Early research in the area of virtual care solutions with peritoneal dialysis (PD) patients has focused on evaluating the outcomes and impact of these solutions. There has been less attention focused on understanding the factors influencing the uptake, usability, and scalability of virtual care for chronic kidney disease (CKD) patients receiving PD at home.

OBJECTIVE

In this context, a study was undertaken to (1) assess and understand the factors influencing the uptake of a virtual care solution and (2) provide recommendations for the scalability of a virtual care solution aimed at enhancing CKD patients’ outcomes and experiences.

METHODS

This study used a qualitative design with semistructured interviews and a thematic analysis approach. A total of 25 stakeholders—6 patients and 3 caregivers, 6 health care providers, 2 vendors, and 8 health system decision makers—participated in this study.

RESULTS

The following three primary mechanisms emerged to influence the usability of the virtual care solution: (1) receiving hands-on training and ongoing communication from a supportive team, (2) adapting to meet user needs and embedding them into workflow, and (3) being influenced by patient and caregiver characteristics. Further, two overarching recommendations were developed for considerations around scalability: (1) co-design locally, embed into the daily workflow, and deploy over time and (2) share the benefits and build the case.

CONCLUSIONS

Study findings can be used by key stakeholders in their future efforts to enhance the implementation, uptake, and scalability of virtual care solutions for CKD and managing PD at home.
Подход к выбору антигистаминного препарата в лечении аллергических заболеваний и состояний в детской практике
Authors: Borysova T.P.
Published: December 2017

В работе представлены механизмы действия современного антигистаминного препарата, эффективность его применения при различных аллергических заболеваниях и состояниях и методы его применения.
Особливості перебігу бронхіальної астми у дітей з надмірною масою тіла та ожирінням
Authors: Volosovets О.P. , Kryvopustov S.P. , Makukha M.T. , Kupkina A.V.
Published: December 2017

У статті розглянуто питання коморбідності бронхіальної астми у дітей із надмірною масою тіла та ожирінням. Описано основні патогенетичні механізми взаємозв’язку бронхіальної астми з надмірною масою тіла та ожирінням. Акцентовано увагу на ролі нейтрофільного запалення у патогенезі бронхіальної астми в таких пацієнтів.
Фатальный исход при коморбидной патологии, усугубившейся гипогликемией
Authors: Shkala L.V. , Myshanych H.I. , Babakova Ye.V.
Published: December 2017

Описан фатальный случай после тяжелой гипогликемии у пациента 45 лет с коморбидной патологией. Сочетание ишемической болезни сердца, кардиосклероза с мерцательной аритмией, осложненных сердечной недостаточностью ІІІ стадии, и сахарного диабета 2-го типа тяжелой формы в стадии декомпенсации на фоне гипертонической болезни ІІІ стадии и ожирения ІІІ стадии имеет крайне неблагоприятный прогноз. Наличие выраженных метаболических, гормональных, функциональных нарушений приводит к полному истощению компенсаторных возможностей организма. В условиях длительной гипогликемии с наслоившимися расстройствами центральных регуляторных систем, процессов микроциркуляции, несмотря на интенсивную терапию, было неизбежным наступление клинической смерти.
Диализная терапия. Преимущества перитонеального диализа в терапии хронической и острой почечной недостаточности
Authors: Kalantarenko Yu.V. , Tomin Ye.V. , Sokolova L.K.
Published: December 2017

В статье приведен обзор исследований посвященных диализной терапии острой и хрнической почечной недостаточности. Рассмотрены преимущества перитонеального диализа.
Оценка эффективности лечения воспалительных заболеваний мужских половых органов трихомонадно-бактериальной этиологии препаратом Грандазол
Authors: Pasechnikov S.P. , Nasheda S.V.
Published: December 2017

В статье представлены результаты исследований клинической и микробиологической эффективности препарата Грандазол в комплексной терапии воспалительных заболеваний мужских половых органов трихомонадно-бактериальной этиологии.
Применение препаратов гиалуроновой кислоты в терапии хронического цистита
Authors: Ivanov D.D. , Dombrovskyi Ya.A.
Published: December 2017

В статье описаны клинические эффекты препаратов гиалуроновой кислоты при лечении хронического цистита. Приведены данные исследований, подтверждающие их эффективность.
Intencionalidad y representación: comprensión de estos conceptos en la gnoselogía de Tomás de Aquino.
Authors: Moya Cañas Patricia
Published: December 2017

This paper intends to give an answer to the type of entity of the intentional being and the intellectual representation of Thomas Aquinas’ thought. Arguments follow the direction of the cognitive act that expresses the own nature of the human being. Intentionality and representation account for a mediation allowing cognitive access to the object itself, so that the referential character of knowledge can be emphasized.
Actividad física en pacientes con diabetes mellitus tipo 2 y relación con características sociodemográficas, clínicas y antropométricas
Authors: Paternina-de la Osa Aura , Villaquirán-Hurtado Andres , Jácome-Velasco Sandra , Galvis-Fernández Brigid , Granados-Vidal Yenny Alexandra
Published: December 2017

Introducción: La Diabetes Mellitus (DM) tipo 2 ha incrementado su prevalencia a nivel mundial, nacional y local, convirtiéndose en una de las principales causas de morbi-mortalidad. Su etiología es múltiple, pero está fuertemente asociada a los hábitos de vida inadecuados tales como los bajos niveles de actividad física y consumo excesivo de azúcares procesados.  Objetivo: Determinar el nivel de actividad física en pacientes con diabetes mellitus tipo 2 en la ciudad de Popayán. Materiales y métodos: Se realizó un estudio observacional - descriptivo de 107 participantes, mediante aplicación del cuestionario internacional de actividad física IPAQ y toma de medidas antropométricas como índice cintura-cadera y pliegues cutáneos. Resultados: El 52,3% de los participantes  tenía sobrepeso, el 82,3% presentó riesgo de comorbilidad y un 36,4% realizaba actividad física moderada. Se calculó la relación entre las variables índice de masa corporal – cHDL (p=0,029), índice cintura cadera (ICC) – presión arterial (p= 0,266), densidad corporal - triglicéridos (p= 0,278), edad e IPAQ (p= 0,000). Conclusión: La diabetes mellitus tipo 2 está asociada a las características antropométricas ligadas al sobrepeso y obesidad, y la falta de actividad física.
Valoración contingente y disponibilidad a pagar por atributos intangibles en carne de bovino
Authors: Jaramillo Villanueva José Luis , Vargas López Samuel , Rojas Juárez Lissete Abigail
Published: December 2017

La demanda de carne de res disminuyó en los últimos años, por lo que analizar la estructura de preferencia de los consumidores es importante. La presente investigación utilizó el Método de valoración contingente (MVC) para determinar las preferencias de los consumidores por los atributos inocuidad, orgánico, precio, contenido de grasa, frescura y color, para descubrir su nicho de mercado. A partir de datos de encuesta a una muestra de 225 hogares, en ciudades del estado de Puebla, se realizó análisis de correlación y un modelo econométrico Probit, para identificar las variables explicativas de la Disponibilidad a pagar (DAP) un sobreprecio por los atributos inocuidad y orgánico. El consumo per cápita de carne fue de 19.4 kg/año, con un coeficiente de variación de 0.205. El 80 % de los consumidores creen que la carne que compran puede estar contaminada en algún grado con sustancias o microorganismos que pueden dañar su salud. El 76 y 66 % de los consumidores tienen DAP un sobreprecio por los atributos inocuidad y orgánico, respectivamente. La DAP promedio por estos atributos es de 13 y 12.1 % respectivamente. Los factores explicativos y significativos (P<0.05) de la DAP son la edad, la escolaridad, el ingreso, la percepción del riesgo, y los atributos contenido de grasa, frescura y suavidad. Los primeros cuatro están asociados con efectos marginales mayores al 20 %. El 14.4 y 19.1 % de la muestra tienen DAP mayor al 25 % del precio que actualmente pagan, porque su carne sea orgánica e inocua, respectivamente.
Teologia política da Reforma: Calvino, Calvinistas e revolucionários
Authors: Rosa Wanderley Pereira da
Published: December 2017

O texto apresenta a evolução da teoria política do reformador João Calvino, de uma visão subserviente ao Estado, mesmo que tirânico, até a possibilidade da resistência armada, liderada pelos magistrados inferiores em caso de grave ameaça à fé. Coube aos calvinistas ingleses e escoceses romper esses limites, advogando a possibilidade de resistência popular, uma vez que o poder dos governantes tem sua origem no povo. O caminho percorrido passou pelas guerras religiosas que assolaram a Europa nos séculos XVI e XVII, os movimentos populares na Inglaterra (XVII) e a defesa pela tolerância religiosa. A partir de bases teológicas, as teorias políticas secularizaram-se e se tornaram o fundamento das modernas democracias.
Making connections: Dinah, Luther and Indian women
Authors: Melanchthon Monica Jyotsna
Published: December 2017

Este ensaio será uma ocupação crítica e pós-colonial feminista índia/asiática com a interpretação de Lutero de Gênesis 34. O ensaio buscará identifi car as doutrinas influentes que moldaram a interpretação de Lutero deste texto. Dará atenção às implicações da leitura de Lutero para a igreja como um todo e para mulheres em particular e as perspectivas que oferece para o empoderamento de uma imaginação informada, justiça, os direitos das mulheres desprivilegiadas na Ásia cujas vozes, vidas e lutas, são frequentemente silenciadasou contidas.
Convocando a Gramsci en América Latina. A propósito de un punto de convergencia en la teoría social en la Argentina contemporánea: Silvio Frondizi y José Aricó
Authors: Barbero Juan Jorge
Published: December 2017

Moviéndonos en la dimensión disciplinar de la sociología política, articularemos en este trabajo ciertos aportes que entre las décadas de 1960 y 1990 esgrimieron los marxistas críticos argentinos Silvio Frondizi y José Aricó. A modo de hipótesis, consideramos que estos aportes pueden ser productivamente vinculados a las temáticas de la “traducibilidad de los lenguajes científicos y filosóficos” y del “constituyentismo”, tratados por Antonio Gramsci en distintos momentos de su trayectoria político-intelectual pero fundamentalmente en sus ya míticos Cuadernos de la cárcel. En el lapso que va de la Revolución Cubana de 1959 a las transiciones a la democracia en América latina en los últimos decenios del siglo XX, lo expuesto por Frondizi y Aricó apunta a desarrollar todo el potencial de la cuestión de la soberanía popular, estructurando así una promesa aún muy débilmente considerada tanto en la cultura como en la política.
Elimination of CT-detected gas bubbles derived from decompression illness with abdominal symptoms after a short hyperbaric oxygen treatment in a monoplace chamber: a case report
Authors:   Hyperbaric Medical Center, Tokyo Medical and Dental University Hospital, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan, Oyaizu Takuya ,   Department of Orthopaedic Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan, Enomoto Mitsuhiro ,   Hyperbaric Medical Center, Tokyo Medical and Dental University Hospital, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan,   Department of Orthopaedic Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan, Tsujimoto Toshihide ,   Department of Critical Care, Wakayama Medical Center Japanese Red Cross Society, 4-20 Komatsubara, Wakayama 641-8558, Japan, Kojima Yasush ,   Hyperbaric Medical Center, Tokyo Medical and Dental University Hospital, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan, Okawa Atsushi ,   Department of Orthopaedic Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan, Yagishita Kazuyoshi ,   Hyperbaric Medical Center, Tokyo Medical and Dental University Hospital, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan,   Department of Orthopaedic Surgery, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Published: December 2017

We report the case of a 54-year-old male compressed- air worker with gas bubbles detected by computed tomography (CT). He had complained of strong abdominal pain 30 minutes after decompression after working at a pressure equivalent to 17 meters of sea water for three hours. The initial CT images revealed gas bubbles in the intrahepatic portal vein, pulmonary artery and bilateral femoral vein. After the first hyperbaric oxygen treatment (HBO2 at 2.5 atmospheres absolute/ATA for 150 minutes), no bubbles were detected on repeat CT examination. The patient still exhibited abdominal distension, mild hypesthesia and slight muscle weakness in the upper extremities. Two sessions of U.S. Navy Treatment Table 6 (TT6) were performed on Days 6 and 7 after onset. The patient recovered completely on Day 7. This report describes the important role of CT imaging in evaluating intravascular gas bubbles as well as eliminating the diagnosis of other conditions when divers or compressed-air workers experience uncommon symptoms of decompression illness. In addition, a short treatment table of HBO2 using non-TT6 HBO2 treatment may be useful to reduce gas bubbles and the severity of decompression illness in emergent cases.
Overview of the analytical methods for vancomycin and/or teicoplanin determination in biological matrices
Authors: Stajic Ana , Jancic-Stojanovic Biljana
Published: December 2017

Background. Teicoplanin and vancomycin are glycopeptide antibiotics currently
in use for treatment of multidrug-resistant bacterial infections. Scope and
Approach. Severe undesirable effects, such as ototoxicity, nephrotoxicity and
neutropenia have been reported for vancomycin and teicoplanin, which
necessitates monitoring the concentration of these two drugs in different
biological samples. In order to obtain precise and accurate results,
sensitive, reliable and fast methods are necessary. The main aim of this mini
review is to give a clear and concise overview of the recently developed,
validated, novel and improved methods for glycopeptide antibiotic analyses in
various biological matrices. Also, the variability of the matrices requires
optimal and effective sample preparation procedures to be developed, and so
these are discussed. Key Findings and Conclusions. Different liquid
chromatography-tandem mass spectrometry (LC-MS/MS) methods have been
described for quantitative determination of glycopeptide antibiotics in
various biological matrices. It was shown that protein precipitation was a
convenient method for sample preparation despite the high number of novel
sample preparation methods.
Systemic lupus erythematosus - diagnostic and treatment challenges
Authors: Brkljacic Mirna , Kajin Filip , Torti Marin , Jovic Ines , Kis Ivana , Smit Iva , Crnogaj Martina , Matijatko Vesna
Published: December 2017

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PENGEMBANGAN PERANGKAT PEMBELAJARAN MATEMATIKA DENGAN LEARNING CYCLE 5E MODEL LORSCBACH KELAS V SEKOLAH DASAR
Authors: Rijal Akmal
Published: December 2017

Learning tools that are used in the schools are still not optimal in facilitating the development of learners. The purpose of this study is to produce a device with a math learning 5E learning cycle model of Lorschbach valid, practical, and effective. This type of research is the development of research. The model used is a model development Plomp. The results showed that the study of mathematics by 5E learning cycle models developed Lorschbach have valid criteria in terms of content and construct. Practical learning device has been good in terms of enforceability, ease, and the time required. Learning device has also been effective in terms of activity and learning outcomes of students with an average value of learners activity increased and the level of mastery learning outcomes. This means learning devices effective in improving learning outcomes of students. Based on these results it can be concluded that the study of mathematics by 5E learning cycle Lorschbach models developed in the study of mathematics in class V SD can be declared valid, practical, and effective.Keywords: Learning tools, math, learning 5E learning cycle model of Lorschbach
DEKONSTRUKSI STRUKTUR PENCERITAAN DALAM NOVEL AROK-DEDES: KAJIAN INTERTEKSTUAL
Authors: Purwantini Purwantini
Published: December 2017

This research aims to understand the meaning of the concept of a transformation work in the era of globalization, namely the novel Arok-Dedes that took the background of Pararaton folklore creation. The novel of Arok-Dedes fought against the characterization of the characters and events in the Pararaton folklore. Thus, the problem is the deconstruction of narrative structures or storytelling structures. The novel was analyzed using the intertextual theory with qualitative methods. The result of the research shows that Arok-Dedes novel is a social critic aimed at the New Order ruler. On the basis of the text of transformation, the state of Indonesia requires a wise leader figure, concerned with the welfare of the people, not self-interest or group interests alone. In the era of globalization, selecting a state leader must be selective, it means having to look at the back-ground of his life, his descendants, his behavior; a leader may not be selected through coup d’etat, treason or passing the buck.
As tecnologias da informação e comunicação como apoio à evolução da internacionalização do ensino superior
Authors: Cassol da Silva Carla Camargo , Morosini Marília Costa
Published: December 2017

No século XXI, a globalização passa a exercer uma forte influência na Educação Superior, e o atual cenário mundial globalizado e interconectado demanda egressos qualificados para atuar nesse contexto. Passam a ser exigências do mundo do trabalho competências globais, interculturais e o uso de tecnologias da informação e comunicação (TICs). Portanto, tanto as TICs como a internacionalização, devem estar presentes e atuantes no processo de ensino e aprendizagem da educação superior. Estudos sobre internacionalização do ensino superior indicam que, para que uma universidade seja considerada internacionalizada, esta deve prover uma experiência educacional internacional para todos os seus alunos. A mobilidade acadêmica ainda está restrita a um percentual limitado da população global de estudantes, seja pela dificuldade de ausência de suas origens, seja por indisponibilidade de recursos financeiros. Assim sendo, as TICs podem ser utilizadas para apoiar alunos no desenvolvimento de perspectivas internacionais, interagindo com pessoas de outras culturas e engajando-se ativamente em um aprendizado intercultural. Este artigo objetiva discutir como as TICs podem apoiar os avanços de internacionalização do ensino superior, bem como provocar reflexões acerca do assunto e dos desafios interpostos às instituições de ensino superior que se propõem a cumprir o seu papel de formar cidadãos globais.Palavras-chave: Ensino Superior. TICs. Internacionalização. Internacionalização do Ensino Superior.
Sperm DNA Methylation, Infertility and Transgenerational Epigenetics
Authors:   Manchester Metropolitan University, Carroll Michael
Published: December 2017

This review will discuss the functions and mechanisms behind DNA methylation, the association of aberrant methylation with male infertility, the implications of lifestyle and environment, and the potential consequences for germ line inheritance of acquired methylation defects.