bluuebunny/crossref_metadata_2025 huggingface dataset:
УДОСКОНАЛЕННЯ МЕТОДУ ОЦІНКИ ПОКАЗНИКІВ НАДІЙНОСТІ ОБЛАДНАННЯ ЗАСОБІВ ВОДНОГО ТРАНСПОРТУ
Authors: Бажак О. В.
Published: June 2022

Аналіз відповідних джерел інформації свідчить про те, що показники якості перевезень пасажирів та вантажів, рівень безаварійного судноводіння продовжують покращуватися. Особлива увага приділяється саме заходам забезпечення заданого рівня безаварійності. Значна роль в цьому напрямку –ефективне рішення завдань навігаційного забезпечення. Це ще більш підкреслює актуальність наукових досліджень з метою підвищення ефективності морських та річкових транспортних засовів за рахунок використання оперативної та достовірної навігаційної інформації.На теперішній час для забезпечення гарантованого рівня достовірності, точності та оперативності навігації використовують прогресивні технологічні рішення на основі супутникової навігації. Аналіз закордонного та вітчизняного досвіду розробки та впровадження систем навігації, які використовують GNSS сигнали свідчить про можливість значного підвищення їх ефективності за рахунок розвитку математичного забезпечення та використання так званих локальний радіонавігаційних систем. Найбільш актуальним в цьому напрямку є використання локальних (псевдосупутникових) радіонавігаційних систем які працюють в форматі GNSS-сигналів саме зі змінною або гнучкою структурою. В таких системах радіонавігаційні точки є мобільними, а це дає змогу оперативне забезпечити задану точність навігації в окремому районі судноводіння.Введення граничного значення на імовірнісний показник ефективності системи формує критерій ефективності як критерій допустимої гарантії. Граничні значення цього показника, а також обмеження щодо точності системи, які входять до складу показника ефективності, задаються розробником на основі знання тактико-технічних характеристик засобів, для забезпечення функціонування яких розгортається псевдосупутникова радіонавігаційна система, та досвіду їх застосування у конкретних умовах обстановки.Ключові слова:навігаційне забезпечення, достовірність, точність та оперативність, псевдосупутникові радіонавігаційні системи, радіонавігаційна точка, радіонавігаційна інформація, GNSS-сигнали
МЕТОДИ РОЗМІЩЕННЯ МАКСИМАЛЬНОЇ КІЛЬКОСТІ ВАНТАЖУ НА СУХОВАНТАЖНИХ СУДНАХ
Authors: Завітаєв В.Л.
Published: June 2022

Складання вантажного плану, одна з головних складових частин перевезення. Це складна робота, що вимагає знання тонкощів технології і специфічних особливостей у процесах доставляння вантажів. Необхідно врахувати всі вимоги, що пред'являються перевізнику, як наприклад: збереження вантажу; безперешкодне та безперебійне вивантаження; забезпечення нормальних техніко-експлуатаційних показників роботи судна; максимальне використання вантажомісткості і вантажопідйомності судна.Вантажний план складається ще до початку навантаження -так званий «попередній план». У ходінавантаження, іноді, від нього роблять відступ через неподання запланованого вантажу, виявлених неточностей у розрахунку, переадресування партій вантажу і т.п.. Тому, після закінчення вантажних операцій складають виконавчий вантажний план, що відповідає фактичному завантаженню. По ньому остаточно уточнюють характеристики міцності, остійності і диференту судна.Правильно завантажити судно -означає забезпечити його безпечне плавання при одночасному максимальному економічному ефекті. Розрахунок вантажного плану -серйозна інженерна робота з великою кількістю рішень, з яких потрібно вибрати оптимальне для цих умов. При цьому саме поняття "оптимальне" не завжди може бути однозначним. У одному випадку -це якнайповніше використання вантажопідйомності або вантажомісткості судна, в іншому -отримання максимального доходу, в третьому -збереження судном каких-або заздалегідь заданих характеристик морехідних якостей і ін.Виробити і рекомендувати усі можливі на практиці способи досягнення оптимального завантаження судна неможливо. Численність конструктивних типів транспортних суден, широка номенклатура вантажів, що перевозяться, і нескінченна кількість можливих їх поєднань, різноманітність напрямів і умов перевезень вимагають творчого підходу до складання вантажного плану в кожному конкретному рейсі.Вантажний план для суховантажного судна найчастіше виконують у вигляді схематичного вертикального розрізу по діаметральної площині. Ключові слова:безпека судна, вантажний план, графичне зображення, максимальне розміщення вантажів, ефективність, критерії остійності судна.
ЗАБЕЗПЕЧЕННЯ ДОПУСТИМОГО ТЕМПЕРАТУРНОГО РІВНЯ ФОРСОВАНИХ СУДНОВИХ ДИЗЕЛІВ З ВИКОРИСТАННЯМ НАНОМАТЕРІАЛІВ
Authors: Горалік Є.Т. , Завітаєв В.Л.
Published: June 2022

Інтенсифікація процесів тепловіддачі в системі охолодження для зниження високих температур деталей КЗ відіграє істотну роль як за рахунок удосконалення режимних та конструктивних параметрів системи, так і за рахунок підвищення коефіцієнта теплопровідності охолоджувальних рідин (ОР). Останнє стало можливим з розвитком нанотехнологій (НТ), що дозволило створювати охолоджувальнінанорідини (ОН), які представляють собою стійкі, стабільні двохфазні суспензії на основі базової ОР та твердих наночасток (НЧ) зі значно більшим коефіцієнтом теплопровідності, ніж у базового теплоносія. Значне збільшення коефіцієнта теплопровідності теплоносія може дозволити істотно підвищити інтенсивність тепловіддачі в системах охолодження ВОД і за рахунок цього забезпечити допустимий температурний рівень їх ТД. Для введення ОН в експлуатацію необхідно провести комплекс досліджень процесів теплообміну при циркуляції цих теплоносіїв зі збільшеним коефіцієнтом теплопровідності в системі охолодження ВОД.Тенденція по збільшенню питомої та агрегатної потужностей головних і допоміжних суднових дизелів разом з удосконалюванням їх масогабаритних показників вимагає нових, додаткових способів підвищення інтенсивності процесів теплообміну в СО двигунів для забезпечення допустимого температурного рівня їх ТД. Проведені дослідження показали, що модифікація теплоносіїв суднових дизелів високо теплопровідними вуглецевими НЧ МГ є ефективним способом інтенсифікації процесів тепловіддачі в СО дизелів з урахуванням розглянутих у магістерській роботі конструктивних заходів. Отримані при дослідженні результати зводяться до наступних основних висновків і рекомендацій:Ключові слова: двигун внутрішнього згоряння, охолодження, наноматеріали, нанотехнології, охолоджувальні рідини.
Связан ли рост заболеваемости сахарным диабетом 2 типа в Якутии уменьшением воздействия холода или изменениями рациона?
Authors: Винокуров Михаил , Тихонов Дмитрий
Published: June 2022

На территории циркумполярных регионов северного полушария 30 тысяч лет проживают люди и на протяжении веков они постоянно боролись холодом за выживание. Положение начало меняться лишь со второй половины ХХ столетия. 20-х гг. прошлого века, когда началась кампания по переустройству традиционного уклада жизни коренного населения региона бывшего Советского Союза. В результате перехода от балаганов (юрт) на дома печным отоплением, а затем на централизованное и газовое отопление существенно повысилась температура внутри жилых домов. В настоящее время накопилась довольно обширная литература связи повышения температуры жилых домов заболеваемостью, связанной с ожирением.
С целью определения роли потепления климата, повышения средней температуры в жилищах в регионе, изменения рациона на заболеваемость сахарным диабетом 2 типа (СД2) нами построено уравнение множественной регрессии с 10 факторами за 20 лет (1994 – 2013 гг.). Модель множественной регрессии были включены следующие факторы: среднегодовая температура в г. Якутске, средняя температура жилища в регионе за отопительный период, потребление овощей, фруктов, сахара, белков, жиров, углеводов в г. в день на человека и суточная калорийность рациона.
Проведенные исследования позволили выяснить что, между заболеваемостью СД2 и потреблением фруктов (ягод), средней температурой жилья, потреблением овощей и бахчевых, калорийностью рациона имеются положительные линейные статистически значимые парные корреляционные связи, но при анализе множественной регрессии роль каждого фактора в развитии СД2 оказывается статистически недостоверной, за исключением уровня потребления фруктов и ягод (при р > 0,05). Следует отметить, что резкий рост показателей заболеваемости СД2 населения Якутии (в том числе коренных жителей) связан многими факторами, но причинной следует считать роль повышенного потребления фруктов и ягод в его развитии, вероятно, обусловленную отсутствием адаптации организма северян поступлению в организм большого количества фруктозы, при высоком уровне потребления жиров.
Частота артериальной гипертензии у эвенков
Authors: Шадрина Светлана , Сивцева Елена
Published: June 2022

Для изучения частоты АГ у эвенков было проведено одномоментное сплошное исследование взрослого населения с. Жилинда Оленекского района в возрасте от 18 лет и старше. Среди коренных жителей Крайнего Севера частота встречаемости АГ, согласно литературным данным, ниже, чем у пришлого населения Севера и жителей средних географических широт. Нами выявлено, что у эвенков, проживающих в условиях северного села, частота артериальной гипертензии составила 33,9%, что соответствует распространенности в среднем по Якутии, и встречается чаще у женщин.
Мониторинг течения артериальной гипертензии женщин, проживающих на территориях холодным климатом
Authors: Донская Ариадна , Шадрина Светлана , Скрыбыкина Елизабета
Published: June 2022

Нами проведен ретроспективный анализ амбулаторных карт женщин с артериальной гипертензией (АГ), состоявших на диспансерном учете у одного терапевта ГАУ РС (Я) «Поликлиника №1» г. Якутска за 2015-2019 г.г. Следует отметить, что г. Якутск находится на территориях, занятых вечной мерзлотой, где минимальная зимняя температура достигает -63ºС. Из литературных источников известно, что холодный климат являются фактором риска развития АГ. Средний возраст женщин составил 58,9±1,9 в начале и 65,9±1,6 к концу наблюдения. Пациентки были разделены на две возрастные группы – молодого/среднего возраста (до 60 лет) и пожилого/старческого возраста (60 и старше). Целью исследования явилось изучение особенностей течения и оценить результаты коррекции АГ у женщин на амбулаторном этапе в процессе мониторинга. По данным амбулаторных карт проанализированы жалобы пациентов, количество обращений по ассоциированным с ГБ состояниями, гемодинамические, лабораторные показатели и гипотензивная терапия в динамике. У наших пациенток в течение 5-ти лет частота общей слабости во второй группе стала заметно реже, частота головной боли в первой группе выросла, но затем снизилась к концу наблюдения. Во второй возрастной группе отмечено повышение триглицеридов (ТГ). В первой возрастной группе медиана диастолического артериального давления (ДАД) в динамике снизилась. Использование селективных бета-адреноблокаторов (БАБ) в комплексной терапии уменьшилась почти вдвое. Несмотря на это, у женщин не участились ни жалобы, ни ассоциированные клинические состояния, ни эпизоды нарушений ритма и проводимости вследствие более рационального лечения препаратами других групп. Улучшение общего самочувствия женщин и снижение ДАД в процессе пятилетнего наблюдения, несомненно, положительную роль сыграла антигипертензивная терапия. Кроме того, мы отмечаем, что за период наблюдения у больных ГБ возросла забота о собственном здоровье, строгое соблюдение рекомендаций специалистов и здорового образа жизни.
В поисках мифа и реальных исторических событий
Authors: Тихонов Дмитрий , Poarch Elisabeth
Published: June 2022

Эллэй и Омогой считаются легендарными предками саха (якутов), коренных жителей Северо-Восточной Сибири и первыми скотоводами на территории средней Лены. Мы выдвинули гипотезу о том, что легендарный Эллэй является исторической личностью.
Цель исследования. Поиск исторического прототипа Эллэя, определение вероятного времени его прибытия на среднюю Лену и истоков скотоводства на этой территории.
Предметы и методы. Нами проведен анализ всех существующих версий легенд об Эллэе, данных гуманитарных, исторических, археологических, генетических исследований, имеющих связь с историческим прототипом героя.
Полученные результаты. Анализируя сказания саха о предках, мы пришли к выводу, что личности и события, описанные в этих легендах, основаны на реальных исторических фактах. Вероятно, крупный рогатый скот начал разводиться на территории Якутии во время возвышения сюнну в начале нашего века.
Заключение. Ряд научных фактов указывает на более ранний период появления якутской породы крупного рогатого скота в Якутии. В настоящее время мы можем с определенной долей вероятности утверждать, что личность Эллэя связана с событиями, происходившими в XII веке в Восточной Азии в период Сунского Китая.
HIS THE INCREASE IN THE INCIDENCE OF TYPE 2 DIABETES IN YAKUTIA DUE TO A DECREASE IN COLD EXPOSURE OR DIETARY CHANGES?
Authors: Vinokurov Mikhail , Tikhonov Dmitrii
Published: June 2022

In Yakutia for 30 thousand years people live, and for centuries they were constantly fighting with the cold for survival [5, 6]. Situation began to change only in the second half of the twentieth century. In 20-ies of the last century a campaign for the reconstruction of traditional Yakut home began. As a result of the transition from balagan (yurts) to houses with stove heating, and then to centralized and gas heating, the temperature inside residential buildings has significantly increased. A fairly extensive literature has now accumulated linking rising residential temperatures with obesity-related morbidity.
In order to determine the role of climate warming, an increase in the average temperature in the houses of the region, and changes in the diet on the incidence of type 2 diabetes, we built a multiple regression equation with 10 factors over 20 years (1994-2013). The following factors were included in the multiple regression model: the average annual temperature in Yakutsk, the average temperature of houses in the region during the heating period, the consumption of vegetables, fruits, sugar, proteins, fats, carbohydrates per year per person, and the daily calorie content of the diet.
The conducted studies made it possible to find out that there are positive linear statistically significant pair correlations between the incidence of DM2 and the consumption of fruits and berries, the average housing temperature, the consumption of vegetables and melons, and the calorie content of the diet, but when analyzing multiple regression, the role of each factor in the development of DM2 turns out to be statistically unreliable, except the level of consumption of fruits and berries (at p > 0.05). It should be noted that a sharp increase in the incidence of DM2 in the population of Yakutia (including indigenous people) is associated with many factors, but the role of increased consumption of fruits and berries in its development should be considered causal, probably due to the lack of adaptation of the body of northerners to intake of large amounts of fructose, with a high level of fat intake.
IN SEARCH OF MYTH AND REAL HISTORICAL EVENTS
Authors: Tikhonov Dmitrii , Poarch Elisabeth
Published: June 2022

Elley and Omogoy are considered the legendary ancestors of the Sakha (Yakuts), the indigenous people of North-Eastern Siberia. We have put forward a hypothesis that the legendary Elley is a historical person and the first pastoralists in the territory of the middle Lena.
The aim of the study search for Elley historical prototype and determine the probable time of his arrival in the middle Lena and the origins of cattle breeding in this territory.
Subjects and methods. The analysis of all the existing versions of the legends about Elley, data from humanitarian, historical, archaeological, genetic studies, which have a connection with the historical prototype of the hero.
Results. Analyzing the Sakha legends about the ancestors, we concluded that the personalities and events described in these legends are based on real historical facts. Probably, cattle began to breed on the territory of Yakutia during the rise of the Xiongnu at the beginning of our century.
Conclusion. A number of scientific facts indicate an earlier period of the appearance of the Yakut cattle breed in Yakutia. At the present time, we can state with a certain degree of probability that the personality of Elley is connected with the events that took place in the XII century in East Asia during the period of Song China.
A Case of Traction Retinal Detachment Accompanied by Ocular Syphilis
Authors: Heo Jeong Woo , Kim Nam Yeong , Kwon Yoon Hyung
Published: June 2022

Purpose: We report a first case of traction retinal detachment accompanied by ocular syphilis in Korea.Case summary: A 20-year-old male visited with poor left-eye vision. His best-corrected visual acuity was 0.3; no inflammation was evident in the anterior chamber, but many inflammatory cells were found in the vitreous cavity. Fundus examination revealed inferior exudative and tractional retinal detachment. Optical coherence tomography revealed an epiretinal membrane; fluorescein angiography showed that the inferior (detached) retina did not fluoresce. Syphilis was serologically detected; ceftriaxone (2 g daily) was intravenously injected for 14 days. The vitreous cavity inflammation improved, but the tractional membrane proliferation triggered tractional retinal detachment. We performed vitrectomy to remove the tractional membrane and prescribed intravitreal antibiotics. The patient was discharged after intravenous injection of penicillin G (20 MU daily) for 14 days. Three months after surgery, the best-corrected left-eye visual acuity had improved to 0.8, and no recurrence of the retinal detachment was noted.Conclusions: Patients with ocular syphilis may evidence retinal detachment despite initial prescription of systemic antibiotics. A possible need for surgery should be kept in mind; the prognosis is good if an operation is performed in a timely manner.
Restrictive Strabismus Developing after Conjunctivodacryocystorhinostomy
Authors: Lee Seong Eun , Lee Yeon Hee , Kim Kyoung Nam , Kim Jaeyoung , Shin Jeong Wha , Lee Sung Bok
Published: June 2022

Purpose: To report a case of diplopia caused by restrictive strabismus developing after conjunctivodacryocystorhinostomy (CDCR).Case summary: A 61-year-old female presented with persistent epiphora after failure to repair ipsilateral canalicular lacerations of the left eye caused by trauma occurred 25 years ago. CDCR was performed and the epiphora improved. Four months later, the patient presented with diplopia on the left gaze. An abduction limitation of -4 and a supraduction limitation of -3 were observed in the left eye. Therefore, Jones tube removal was performed 5 months after CDCR surgery. Two weeks later, as the limitations persisted, adhesiolysis of the conjunctiva and an amniotic membrane transplantation (AMT) were performed. This exposed a subconjunctival adhesion at the inferonasal conjunctiva; histopathological examination revealed fibrotic tissues. Three months later, the adhesions recurred and the patient was transferred to another hospital. Conjunctival adhesiolysis, AMT, and a 6.5 mm recession of medial rectus (MR) muscle were performed. One week later, exotropia occurred in the primary position, and the MR muscle of the left eye was advanced by 2 mm. Nine months after the final surgery, the primary gaze was orthotropia. The diplopia within the central 20° of visual field had disappeared. However, a levoelevation limitation of -1.5 remained in the left eye.Conclusions: CDCR is the only treatment method for patients with occlusion of both the upper and lower proximal lacrimal canaliculi. However, rare complications such as restrictive strabismus with diplopia may occur. As preventing adhesion is difficult, sufficient patient notice is required prior to surgery.
Acquisition of Own Shares by Corporations Whose Shares Are Traded on the Stock Exchange Within the Framework Shaped by Press Announcements of Capital Markets Board
Authors: TARHAN Damla Gül
Published: June 2022

The rules for acquisition of own shares by corporations whose shares traded on the stock exchange are specified in capital markets law. Capital Markets Board has enacted II-22.1 Communiqué On Buy-Backed Shares by exercising the power recognised in the Article 22 of Capital Markets Law with the code number 6362. Besides, the Board has adopted two public announcements which render buy-backs applicable in a wider scope for corporations whose shares traded on the stock exchange as an alternative way to buy-backs programs. In 2020, within the measures with respect to capital markets in response to the Covid-19 Outbreak, it is remembered that Board’s public announcements made in 2016 are still in force.

Specifying an alternative system for existing legal framework for buy-backs by rendering particular provisions non-applicable in secondary legislation via public announcements is controversial in terms of the preference regarding the type of regulation and the place of liberalization of buy-backs of corporations whose shares traded on the stock exchange within the system as a whole. In this article, it is aimed to examine the current system regarding the acquisition of own shares by corporations whose shares traded on the stock exchange. The content of the press announcements will be revealed after the positive legal rules on the subject are determined first. After that, the alternative and more liberal system brought by the Board via press announcements and the rules for acquiring of own shares for corporations whose shares are traded on the stock exchange will be evaluated in terms of the Board's regulatory powers and effects of the content of the announcements on the practice of buy-backs.
Sedanter Kadınlarda Elektriksel Kas Uyarımı (EMS) ve Geleneksel Antrenmanın Kuvvet Kazanımı ve Antropometrik Özellikler Üzerine Etkisinin İncelenmesi
Authors: Öktem Uğur , Akın Manolya
Published: June 2022

Bu çalışmanın amacı, Elektriksel Kas Uyarımı (EMS) antrenmanı ile geleneksel fitness antrenmanı uygulamalarının sedanter kadınlar üzerinde antropometrik ve kuvvet değerleri üzerine olan etkilerinin incelenmesidir. Araştırmaya Osmaniye ilinde yaşayan 20 sedanter kadın (yaş 25.40 ± 1.10) gönüllü olarak katılmıştır. Katılımcılar EMS ve fitness antrenman grubu olarak iki gruba ayrılmıştır. Verilerin normallik dağılımına Shapiro-Wilk sınaması ile bakılmıştır. Veriler normal dağılım gösterdiğinden 6 hafta uygulanan antrenmanların ön test ve son test antropometrik ve kuvvet karşılaştırmaları için bağımlı gruplar T testi kullanılmıştır. EMS ve fitness grubunun antropometrik değişkenlere (vücut ağırlığı, vücut kütle indeksi, yağ yüzde değerleri ve yağsız vücut kütlesi) göre ön test-son test değerleri arasında istatiksel olarak anlamlı farklılık görülmemiştir (p>0.05). Çevre ölçümlerinde EMS antrenman grubunun ön test son test değerlerinde istatistiksel olarak anlamlı farklılık bulunmamıştır (p>0.05). Fitness antrenman grubunda biceps ve biceps kasılı çevre ölçümlerinde fark anlamlı bulunurken karın, kalça ve göğüs çevresinde EMS grubunda olduğu gibi anlamlı farklılık bulunmamıştır. Çalışma sonucunda, EMS ve Fitness grubunun kuvvet ön test- son test değerlerinde anlamlı farklar bulunmuştur. Sonuç olarak EMS antrenmanı ve geleneksel fitness antrenmanı sonucu sedanter kadınlarda kuvvet kazanımı sağlanmıştır. Bu bulgudan hareketle sakatlık riskinin daha az olduğu kısa sürede ve kolay uygulanabilen yeni teknoloji EMS antrenmanları geleneksel fitness antrenmanlara ek olarak önerilmektedir.
Implementation of Inquiry and Group Methods Investigation in PJOK Towards Student’s Participation and Critical Thinking
Authors: Cahyadi Eka , Hariyanto Agus , Kartiko Dwi Cahyo
Published: June 2022

Physical education is an important part of developing students' interests and talents in schools. Teachers must have a strategy for learners. This research aims to analyze the implementation of the inquiry learning method and group investigation on participation and critical thinking of students. This research was quasi-experiment by using two group pretest-posttest design. The sample in this research were 51 eighth grade students of SMPN 4 Pamekasan. The data collection was carried out using questionnaires and students’ activity assessment sheets. Furthermore, the data analysis was carried out univariate by using the SPSS application. The results of this study in group 1 with the inquiry learning method showed an average increase in student participation by 5%, and critical thinking by 8.8%. Furthermore, the group investigation method in group 2 showed an average increase in student participation by 7.3% and critical thinking by 15.2%.
The Effect of Targeted Ball Throwing Training on Smash Accuracy of Volleyball
Authors: Salahuddin Muhammad , Said Hariadi , Juadi Bahtiar
Published: June 2022

Based on the background of the problems in the TBL club, the aim of this research is to practice target ball throwing against the accuracy of the volleyball smash at the TBL Junior Volleyball Club, Taliabu Regency. The research objective is to determine the effect of target ball throwing training on smash accuracy of volleyball at the TBL Junior Club, Taliabu Regency. The population were 10 people. The method of this research used one group pretest-posttest. The research design used experiment, it has a pre-test post-test. Based on the results of the t-test of the pre-test data and the post test on smash accuracy of volleyball at the TBL junior club, Taliabu Regency, it can be obtained a significance value of 0.000 < 0.05, which means that there is an influence in the pre-test to the post-test on smash accuracy of volleyball at the TBL juniors club in Taliabu Regency with a significant target ball throwing practice, judging from the average score for the final test of 16.90 minus the initial test of 14.00. With these results, it shows an increase in the average value of 2.90.
The Effect of EMS Exercise on Body Circumstances in Sedentary Women
Authors: Dyaksa Rizky Sota , Susilo Eko Andi , Virdianto Achmad Wahyu
Published: June 2022

Today's society is aware of the importance of health. Now many people are competing to do physical activity. This is done to prevent the occurrence of diseases such as diabetes, blockage of blood vessels caused by fat. Currently, there are many types of sports, one of which is Electro Muscle Stimulation (EMS). This EMS device uses electrical waves to artificially stimulate muscles. This research method is an experimental pretest-posttest design. The subject is female as many as 10 people. Exercises were carried out using a total body EMS with a duration of 20 minutes for core and 5 minutes for cooling down, performed 2x/week for 6 weeks. The exercise was carried out when the research subjects had enough sleep and the pulse was below 80-110 minutes. The variable in this study was subcutaneous fat with measurements using a simple meter to determine right-left upper arm circumference, abdominal circumference, right and left thigh circumference. The results of this study were that there were significant differences in the circumferences of the upper arms, abdomen and thighs where the results of the SPSS static analysis showed a value of <0.05.
Correlation Analysis Between Practicality and Effectiveness of Physical Education Curriculum in Senior High School
Authors: Irawan Rista Aden , Bekti Susilo , Lani Ahmad
Published: June 2022

In education, the curriculum is the most important needs. It becomes a practice guidance for teachers. Moreover, the curriculum was made to be implemented, so that the most important measurement of good curriculum is the practical aspect. This research is classified as quantitative research with statistical correlation analysis. The research data were collected through a questionnaire distributed online in the form of a Google Form application containing curriculum implementation. This research used participants of National Webinar entitled "Physical Education and Sports for Millennials in the New Normal Era". Furthermore, data processing was carried out through the SPSS application and analyzed by means of a single average test (one sample t-test) and correlation. From the results of the correlation test analysis, it was found that the correlation between the practicality value and the effectiveness was 0.776. The limitation of this research was that the researcher only examined the high school curriculum. It did not examine the curriculum in elementary and junior high schools. This research concluded that the curriculum for Physical Education, Sports and Health subjects has met the practicality criteria and effectiveness criteria, and there is a relationship between practicality and curriculum effectiveness. The more practical a curriculum is, the more effective the curriculum will be.
Analysis of Physical Education, Sports and Health teacher Strategies in Learning FMS During the Covid Pandemic 19
Authors: Yuliastrid Dita , Jatmiko Tutur , Hafidz Abdul , Suroto Suroto , Mutohir Toho Cholik
Published: June 2022

The purpose of this study is to find an overview of how the learning strategies and barriers for Physical Education, Sports and Health teachers providing fundamental movement material during the Covid 19 pandemic. This research includes quantitative descriptive analysis. This research used survey method with close-ended question as the instrument distributed on google form. Respondents in this study were primary school PJOK teachers, in which about 49 people. Data were analyzed using percentage calculations. The conclusions of this study indicate that fundamental movement learning is carried out online by utilizing various kinds of teaching materials such as books, PowerPoint slides, videos, and handouts. The most widely used media is the WhatsApp group. The learning method used by PJOK teachers is the assignment method. The learning strategies carried out generally give students the task of imitating movements, repeating movements, and recording activities. In general, PJOK teachers do not experience obstacles in conducting online learning.
Development of Aerobic Endurance Training Method (Oxidative Steady State) Through Android Aplication
Authors: Sinulingga Andrew Rinaldi , Nova Andi , Lardika Rolla Angga , S Wedi , Firmansyah Guntur
Published: June 2022

This study aims to develop an aerobic (oxidative steady-state) method of exercise based on an android application to improve the aerobic endurance of athletes, specifically in football. This application is designed according to the composition of aerobic endurance training. This application is beneficial in the current new normal situation, which requires players to practice independently. In addition, The application is expected to be a solution to the current situation—methods and steps in this study using the ADDIE model consist of 5 stages. The subjects in the study were two material experts, one media expert, and ten students who were learning about media users. The research was conducted at the Department of Sports Education, Riau University. The results of the development research tested in small groups were stated to be very feasible and suitable to be used as a guide to increase aerobic capacity. This application is still necessary to test in large groups in the use of this application to find out whether this learning media can be used by users widely
Improving the performance of tax bailiffs through understanding the effects of job characteristics, job demands, and compensation
Authors: Caecilia diah permatasari
Published: June 2022

Tax bailiffs are employees at the Directorate General of Taxes in charge of collecting tax revenues through the implementation of collection actions against taxpayers who are in arrears with taxes. The achievement of collecting tax revenues is not optimal because there are still tax bailiffs who have not performed well. This study aims to analyze and find out the effect of job characteristics, job demands, and compensation on the performance of tax bailiffs. The research design uses quantitative methods, data is collected through questionnaires involving 130 tax bailiffs who work in 63 Tax Offices in Indonesia. Data analysis used Structural Equation Model SMART PLS 3.0. Findings. The results of the study support that job characteristics and compensation have a significant positive effect on work engagement. Job characteristics, job demands, and work engagement have a significant positive effect on performance. Meanwhile, job demands do not affect work engagement, while compensation does not affect performance. The implication of this research is the need to strengthen job characteristics, provide appropriate soft skills to support job demands, and improve the compensation system for tax bailiffs so that tax bailiffs' performance is improved to support optimal tax revenue.
A Bibliometric and Visual Analysis of Nanocomposite Hydrogels Based on VOSviewer From 2010 to 2022
Authors: Zhao Mingyi , Zhang Hanqi , Li Zixin
Published: June 2022

Background: Nanocomposite hydrogels (NHs) are stable composite materials formed by dispersing nanomaterials in hydrogels and have broad development prospects in the biomedical field. In this study, we aimed to systematically and comprehensively evaluate the trends and hot spots of biomedical applications of NHs from 2010 to 2022.

Methods: In total, 713 articles and reviews related to NH applications in the biomedical field from 2010 to 2022 were retrieved from the Web of Science Core Collection (WOSCC). Two scientometric software programs, VOSviewer and Microsoft Excel 2019, were used to visually perform bibliometric analysis in terms of research trends, sources, the contribution of journals, co-citation, and the co-occurrence of keywords.

Results: From 1 January 2010 to 3 February 2022, the number of annual scientific publications about NHs exhibited an upward trend, and research articles were published in a larger proportion (more than 77%). The top three countries in NH research were China, the United States, and India. Meanwhile, Tabriz University of Medical Sciences, the Chinese Academy of Sciences, and Tshwane University of Technology were the most active and contributive. In the contribution of journals, the journal Advanced Functional Materials had the highest number of publications, and the journal Int J Biol Macro had the most citations. Varaprasad K was the most prolific author, and Haraguchi K ranked first among co-cited authors. In the ranking of frequency in the co-cited references, Nanocomposite Hydrogels for Biomedical Applications, published by Gaharwar AK, was the most frequently cited reference. The keyword with the highest frequency was “drug delivery.”

Conclusion: This study performed a full overview of NHs using bibliometrics and identified current trends and hot spots. This information may help researchers focusing on NHs to identify developments in this field.
Manganese-Based Prussian Blue Nanocatalysts Suppress Non-Small Cell Lung Cancer Growth and Metastasis via Photothermal and Chemodynamic Therapy
Authors: Fang Danruo , Liu Zeyu , Jin Hansong , Huang Xiulin , Shi Yongxin , Ben Suqin
Published: June 2022

Based on the safety of prussian blue (PB) in biomedical application, we prepared manganese-based prussian blue (MnPB) nanocatalysts to achieve enhanced photothermal therapy and chemodynamic therapy. And we conducted a series of experiments to explore the therapeutic effects of MnPB nanoparticles (NPs) on non-small cell lung cancer (NSCLC) in vivo and in vitro. For in vitro experiments, the MnPB NPs suppressed growth of A549 cells by reactive oxygen species upregulation and near-infrared irradiation. Moreover, the MnPB NPs could inhibit lung cancer metastasis through downregulating the matrix metalloproteinase (MMP)-2 and MMP-9 expression in A549 cells. And for in vivo experiments, the MnPB NPs inhibited the growth of xenografted tumor effectively and were biologically safe. Meanwhile, Mn2+ as a T1-weighted agent could realize magnetic resonance imaging-guided diagnosis and treatment. To sum up, the results in this study clearly demonstrated that the MnPB NPs had remarkable effects for inhibiting the growth and metastasis of NSCLC and might serve as a promising multifunctional nanoplatform for NSCLC treatment.
Major Advances in Emerging Degrader Technologies
Authors: Luo Hang , Wu Li , He Yujian , Qin Chong , Tang Xinjing
Published: June 2022

Recently, degrader technologies have attracted increasing interest in the academic field and the pharmaceuticals industry. As one of the degrader technologies, proteolysis-targeting chimeras (PROTACs) have emerged as an attractive pharmaceutical development approach due to their catalytic ability to degrade numerous undruggable disease-causing proteins. Despite the remarkable progress, many aspects of traditional PROTACs still remain elusive. Its expansion could lead to PROTACs with new paradigm. Currently, many reviews focused on the design and optimization strategies through summarizing classical PROTACs, application in diseases and prospect of PROTACs. In this review, we categorize various emerging PROTACs ranging from simply modified classical PROTACs to atypical PROTACs such as nucleic acid-based PROTACs, and we put more emphasis on molecular design of PROTACs with different strategies. Furthermore, we summarize alternatives of PROTACs as lysosome-targeting chimeras (LYTACs) and macroautophagy degradation targeting chimeras (MADTACs) based on different degradation mechanism despite of lysosomal pathway. Beyond these protein degraders, targeting RNA degradation with the potential for cancer and virus therapeutics has been discussed. In doing so, we provide our perspective on the potential development or concerns of each degrader technology. Overall, we hope this review will offer a better mechanistic understanding of emerging degraders and prove as useful guide for the development of the coming degrader technologies.
WNK1 in Malignant Behaviors: A Potential Target for Cancer?
Authors: Jung Ji-Ung , Jaykumar Ankita B. , Cobb Melanie H.
Published: June 2022

Metastasis is the major cause of mortality in cancer patients. Analyses of mouse models and patient data have implicated the protein kinase WNK1 as one of a handful of genes uniquely linked to a subset of invasive cancers. WNK1 signaling pathways are widely implicated in the regulation of ion co-transporters and in controlling cell responses to osmotic stress. In this review we will discuss its actions in tumor malignancy in human cancers and present evidence for its function in invasion, migration, angiogenesis and mesenchymal transition.
Epidemiology and Genomic Characteristics of Bloodstream Infection Caused by Carbapenem-Resistant Klebsiella pneumoniae With Decreased Susceptibility to Aztreonam/Avibactam in China
Authors: Yu Wei , Shen Ping , Chen Yunbo , Zhou Kai , Chi Xiaohui , Xiao Yonghong
Published: June 2022

Aztreonam/avibactam (AZA), as one of the novel β-lactamases and β-lactamase inhibitor combinations, is considered to be a promising option for bloodstream infection (BSI) of carbapenem-resistant Klebsiella pneumoniae (CR-Kp). However, decreased susceptibility of AZA activity in Enterobacterales has been reported. The aim of this study was to identify the mechanisms of BSI CR-Kp with decreased susceptibility of AZA (minimal inhibitory concentration above 16/4 mg/L) (AZAH-Kp). Nine BSI AZAH-Kp isolates were screened from 317 CR-Kp isolates in Blood Bacterial Resistant Investigation Collaborative System (BRICS) program. Whole genome sequencing, bioinformatics analysis, and the relative expression of blaKPC, ompK35, and ompK37 were explored for CR-Kp with decreased susceptibility to AZA. The results revealed that elevated inhibitory concentration of AZA has emerged in CR-Kp before previous clinical exposure. In addition, decreased AZA susceptibility was associated with higher KPC expression and changes in OmpK35-37.
The Nationally Determined Contribution Expert Tool (NEXT): A Comprehensive Greenhouse Gas Accounting Tool to Support Annual Environmental Impact Assessment Over a 30-Year Time Series in the Agriculture, Forestry and Other Land Use Sector
Authors: Schiettecatte Laure-Sophie , Audebert Philip , Umulisa Viviane , Dionisio Daniel , Bernoux Martial
Published: June 2022

The Nationally Determined Contribution Expert Tool (NEXT) is a greenhouse gas accounting tool developed by the Food and Agriculture Organization of the United Nations (FAO) to support annual environmental impact assessment for the Agriculture, Forestry and Other Land Use sector (AFOLU). It provides a 30-year time series of annual and cumulated estimates of carbon removal and greenhouse gas emission reductions from actions determined by Parties in their climate policies. NEXT was developed using the Intergovernmental Panel on Climate Change (IPCC) methodologies, and estimates can be made using either the IPCC 2006 guidelines or the IPCC 2019 refinement to the IPCC 2006 which are both complemented with the IPCC 2013 Wetlands Supplement. The tool was designed to provide results that directly respond to the provisions of the Enhanced Transparency Framework and support the Nationally Determined Contributions (NDC) development as required by the modalities, procedures and guidelines. NEXT provides a detailed temporal series of results and a wide set of indicators, including the social value of carbon, enabling a comprehensive environmental and economic overview of climate actions in achieving mitigation targets. The tool helps countries to interpret, track and scale up ambition of their NDCs which could ultimately inform the global stocktake of the Paris Agreement in a harmonized way.
Prevention of Anthracycline-Induced Cardiotoxicity: The Good and Bad of Current and Alternative Therapies
Authors: Sangweni Nonhlakanipho F. , van Vuuren Derick , Mabasa Lawrence , Gabuza Kwazi , Huisamen Barbara , Naidoo Sharnay , Barry Reenen , Johnson Rabia
Published: June 2022

Doxorubicin (Dox)-induced cardiotoxicity (DIC) remains a serious health burden, especially in developing countries. Unfortunately, the high cost of current preventative strategies has marginalized numerous cancer patients because of socio-economic factors. In addition, the efficacy of these strategies, without reducing the chemotherapeutic properties of Dox, is frequently questioned. These limitations have widened the gap and necessity for alternative medicines, like flavonoids, to be investigated. However, new therapeutics may also present their own shortcomings, ruling out the idea of “natural is safe”. The U.S. Food and Drug Administration (FDA) has stipulated that the concept of drug-safety be considered in all pre-clinical and clinical studies, to explore the pharmacokinetics and potential interactions of the drugs being investigated. As such our studies on flavonoids, as cardio-protectants against DIC, have been centered around cardiac and cancer models, to ensure that the efficacy of Dox is preserved. Our findings thus far suggest that flavonoids of Galenia africana could be suitable candidates for the prevention of DIC. However, this still requires further investigation, which would focus on drug-interactions as well as in vivo experimental models to determine the extent of cardioprotection.
Geochemical Characteristics and Origin of Shale Gases From Sichuan Basin, China
Authors: Ni Yunyan , Dong Dazhong , Yao Limiao , Chen Jianping , Liang Xing , Liu Fei , Li Jian , Guo Jinhao , Gao Jinliang
Published: June 2022

Natural gases from the Taiyang (shallow), Jiaoshiba (middle), and Weirong (deep) shale gas fields in the southern Sichuan Basin were analyzed for molecular and stable carbon isotopic compositions to investigate the geochemical characteristics and gas origins. All the gases belong to shale gas from the Upper Ordovician–Lower Silurian shale and are dominated by methane with gas wetness generally less than 0.83%. The δ13C1 values are −28.5‰, −30.3‰, and −35.2‰ in Taiyang, Jiaoshiba, and Weirong shale gas fields, respectively. The extremely high thermal maturity is the controlling factor for the enrichment of 13C in methane, with a minor contribution from the heavy carbon isotope of the organic matter in the Ordovician Wufeng Formation. Fischer–Tropsch-type synthesis of hydrocarbon gas from CO2 and H2 contributes to the increase of wet gas, which results in the offset from the δ13C1∼wetness linear trend in the Taiyang and Jiaoshiba gas fields. Methane, ethane, and propane in the Taiyang shale gas field have increasing δ13C values with increasing burial depth, which is mainly caused by diffusive migration. All gases are characterized by a complete carbon isotopic reversal trend (δ13C1 > δ13C2 > δ13C3), and it is mainly caused by the reversible free-radical reactions with the conversion from alkane to alkyl groups, with some contribution from the Fischer–Tropsch-type synthesis. The results of this study will improve our understanding of the geochemical characteristics of shale gases from different burial depths and have important implications for future shale gas exploration in the deep and shallow layers.
Prediabetes: Adherence to Nutrition Visits Decreases HbA1c in Children and Adolescents
Authors: Parajuli Sadichchha , Jasmin Gabrielle , Sirak Hannan , Lee Austin F. , Nwosu Benjamin Udoka
Published: June 2022

Background

Prediabetes, the precursor of type 2 diabetes (T2D), is on the rise in the US, but the determinants of its progression are poorly characterized in youth.

Objective

To determine the impact of nutrition visits, as a surrogate marker of lifestyle modification, on the trajectory of prediabetes over a 4-year period.

Hypothesis

Adherence to nutrition visits could reduce BMI and lower HbA1c.

Methods

A 4-year retrospective study of 108 youth with prediabetes who were recommended to receive medical nutrition therapy every 3 months following their diagnosis. Subjects were divided into 2 groups: the non-adherent group who had ≤1 nutrition visit/year, and the adherent group with ≥2 nutrition visits/year.

Results

There were 46 male subjects, mean age 12.4 ± 3.6y; and 62 female subjects, mean age, 13.3 ± 3.0y, p=0.2. The adherent group (n=44, 41.5%) had higher BMI z-scores, but similar values for HbA1c, metformin use, and racial/ethnic composition compared to the non-adherent group. Overall, 18(17.0%) subjects progressed to T2D in 4y and consisted of 14(22.6%) of the 62 non-adherent subjects and 4(9.1%) of the 44 adherent subjects. The non-adherent subjects progressed to T2D at a mean duration of 25.8 ± 12.6 months while the adherent subjects progressed at a mean duration of 34.9 ± 11.8 months. The hazard ratio of progression from prediabetes to T2D for the non-adherent versus adherent group was 3.88 (95%CI 1.26-11.98, p=0.02). The results remained significant after adjusting for age, sex, race/ethnicity, BMI, and metformin use.

Conclusion

Adherence to nutrition visits was associated with a 4-fold reduction in the likelihood to progress from prediabetes to T2D in US youth.
Experimental Validation of a Numerical Model to Predict the Performance of Solar PV Cells
Authors: Asim Muhammad , Usman Muhammad , Hussain Jafar , Farooq Muhammad , Naseer Muhammad Irfan , Fouad Yasser , Mujtaba M.A. , Almehmadi Fahad Awjah
Published: June 2022

The models designed to evaluate the performance of photovoltaic (PV) cells depend on classical thermal principles with the use of constant optical coefficients (reflectance, absorbance, and transmittance). However, these optical coefficients depend on incident angle actually and, hence, are a function of the inclination and orientation of the PV panel along with the geographical location and time of the day. In this study, varying coefficients (optical thermal model) and constant coefficient (classical thermal model) with incident angle in the energy balance equations followed by experimental validation were considered. First, the incident angle of direct radiation on the PV panel was determined with the help of astronomic simplified calculations, and second, the optical coefficients were evaluated by using principles of classical electromagnetic theory. Third, the energy balance equations were expressed in the form of differential equations and solved numerically by the Runge–Kutta method to obtain the electrical power as a function of time. Finally, electrical power produced by the optical–thermal model and classical thermal model was validated against experimental data for the solar PV system installed at the Central Station, Punjab Emergency Service. The results show that there is significant agreement between the classical thermal model and experimentally produced electricity throughout the year which validates the modeling.