bluuebunny/crossref_metadata_2025 huggingface dataset:
Multi‐Objective Cost‐Detectability in Unfalsified Adaptive Control
Authors: Sajjanshetty Kiran S. , Safonov Michael G.
Published: June 2016

Vector‐valued controller cost functions that are solely data‐dependent and reflect multiple objectives of a control system are examined within the framework of unfalsified adaptive control. The notion of Pareto optimality of vector‐valued cost functions and the conditions under which they are cost‐detectable are discussed. A sampled data/discrete‐time Level‐Set controller switching algorithm is investigated which allows for the relaxation of the assumption that the controller cost function be monotonically nondecreasing in time. This opens up the possibility of the use of fading memory cost functions which are nonmonotone. When an active controller is falsified at the current threshold cost level, the Level‐Set switching algorithm replaces it by an effectively unique solution of the weighted Tchebycheff method, thus ensuring the selection of an unfalsified Pareto optimal controller. Theoretical results for convergence and stability of the adaptive system are given. Simulation results validate the use of cost‐detectable multi‐objective cost functions. An example of a cost‐detectable cost function which uses fading memory norm of the fictitious tracking error as a performance measure is shown. This allows for computation of performance of nonactive controllers with respect to a reference model.
Wissenschaft im Glaubenskampf. Geschichte als Argument in den akademischen Festreden Emil DuBois‐Reymonds (1818–1896)
Authors: Leber Christoffer , Nickelsen Kärin
Published: June 2016

The Religious War of Science. Historical Argumentation in the Academic Speeches of Emil DuBois‐Reymond (1818–1896). Among the protagonists of the “laboratory revolution” (Cunningham/Williams) in 19th‐century physiology were the self‐proclaimed ‘organic physicists’ (“organische Physiker”), who shared a mechanistic conception of life processes. One of their key figures was the physiologist Emil DuBois‐Reymond (1818–1896) who not only excelled in the field of neuroscience but also became known, over the decades of his active career, as an orator at the Berlin Academy of Sciences and Humanities. In his academic speeches, DuBois‐Reymond regularly commemorated heroes of the history of science. On closer inspection, these references went far beyond paying the usual homage to precursors: This paper argues that DuBois‐Reymond made use of episodes from the history of science as a means to legitimate his own reductionist research programme and, at the same time, decry idealistic natural philosophy and vitalistic positions. Drawing upon biblical rhetorics, DuBois‐Reymond systematically construed experimental physiology as the culmination of a teleological development, and, hence, organic physicists as the incarnation of scientific ‘redeemers’. According to him, the success of ‘organic physics’ displayed the peak of an inevitable development.
Controlling the time evolution of mAb N‐linked glycosylation, Part I: Microbioreactor experiments
Authors: Villiger Thomas K. , Roulet Anaïs , Périlleux Arnaud , Stettler Matthieu , Broly Hervé , Morbidelli Massimo , Soos Miroslav
Published: June 2016

N‐linked glycosylation is of key importance for the efficacy of many biotherapeutic proteins such as monoclonal antibodies (mAbs). Media components and cell culture conditions have been shown to significantly affect N‐linked glycosylation during the production of glycoproteins using mammalian cell fed‐batch cultures. These parameters inevitably change in modern industrial processes with concentrated feed additions and cell densities beyond 2 × 107 cells/mL. In order to control the time‐dependent changes of protein glycosylation, an automated microbioreactor system was used to investigate the effects of culture pH, ammonia, galactose, and manganese chloride supplementation on nucleotide sugars as well as mAb N‐linked glycosylation in a time‐dependent way. Two different strategies comprising of a single shift of culture conditions as well as multiple media supplementations along the culture duration were applied to obtain changing and constant glycosylation profiles. The different feeding approaches enabled constant glycosylation patterns throughout the entire culture duration at different levels. By modulating the time evolution of the mAb glycan pattern, not only the endpoint but also the ratios between different glycosylation structures could be modified. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 32:1123–1134, 2016
Generation of stable Chinese hamster ovary pools yielding antibody titers of up to 7.6 g/L using the piggyBac transposon system
Authors: Rajendra Yashas , Peery Robert B. , Barnard Gavin C.
Published: June 2016

Chinese hamster ovary (CHO) cells remain the default production host for many biopharmaceutical drugs, particularly monoclonal antibodies (mAb). Production of gram and kilogram quantities of protein typically requires the generation of stable CHO clones. Unfortunately, this process takes several months, significantly slowing down the drug discovery and development process. Therefore, improved technologies are needed to accelerate biopharmaceutical drug discovery and final drug substance manufacturing. In this study, we describe the generation of stable CHO pools using the piggyBac transposon system. We evaluated the system using four model antibody molecules (3 mAbs and 1 bispecific Ab). Stable CHO pools were isolated in 7–12 days. Using a simple 16‐day fed‐batch process, we measured titers ranging from 2.3 to 7.6 g/L for the four model antibodies. This represented a 4‐ to 12‐fold increase relative to the controls. Additionally, we isolated stable CHO clones. We found that the stable CHO clones isolated from the piggyBac transposon pools yielded titers two to threefold higher relative to the control clones. Taken together, these results suggest that stable CHO pool and clone generation can be significantly improved by using the piggyBac transposon system. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 32:1301–1307, 2016
Understanding and optimizing the addition of phytohormones in the culture of microalgae for lipid production
Authors: González‐Garcinuño Álvaro , Sánchez‐Álvarez José M. , Galán Miguel A. , Martin del Valle Eva M.
Published: June 2016

Some studies have described the use of phytohormones in microalgal culture for the production of biodiesel or selected fatty acids. However, no study has determined the amount of phytohormones that maximizes lipid yield. We determined the optimal concentration of auxins and gibberellins (which is between 40 and 60 μM) in two strains (Scenedemus abundans and Chlorella ellipsoidea) suitable for biodiesel production. More than 3‐fold increment was reached with S. abundans and near 7‐fold increment with C. ellipsoidea. Furthermore, this work suggests that the improved growth of the microalgae in the presence of the phytohormones was due to a reduction in the level of reactive oxygen species (ROS) in the cells. An economic analysis showed that, due to its low cost, auxin offers a positive cost‐benefit balance and therefore could be used at large scale. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 32:1203–1211, 2016
Uptake of inorganic and organic nutrient species during cultivation of a Chlorella isolate in anaerobically digested dairy waste
Authors: Wahal Shantanu , Viamajala Sridhar
Published: June 2016

A natural assemblage of microalgae from a facultative lagoon system treating municipal wastewater was enriched for growth in the effluents of an anaerobic digester processing dairy waste. A green microalga with close resemblance to Chlorella sp. was found to be dominant after multiple cycles of sub‐culturing. Subsequently, the strain (designated as LLAI) was isolated and cultivated in 20× diluted digester effluents under various incident light intensities (255–1,100 µmoles m−2 s−1) to systematically assess growth and nutrient utilization. Our results showed that LLAI production increased with increasing incident light and a maximum productivity of 0.34 g L−1 d−1 was attained when the incident irradiance was 1,100 µmoles m−2 s−1. Lack of growth in the absence of light indicated that the cultures did not grow heterotrophically on the organic compounds present in the medium. However, the cultures were able to uptake organic N and P under phototrophic conditions and our calculations suggest that the carbon associated with these organic nutrients contributed significantly to the production of biomass. Overall, under high light conditions, LLAI cultures utilized half of the soluble organic nitrogen and >90% of the ammonium, orthophosphate, and dissolved organic phosphorus present in the diluted waste. Strain LLAI was also found to accumulate triacylglycerides (TAG) even before the onset of nutrient limitation and a lipid productivity of 37 mg‐TAG L−1 d−1 was measured in cultures incubated at an incident irradiance of 1,100 µmoles m−2 s−1. The results of this study suggest that microalgae isolates from natural environments are well‐suited for nutrient remediation and biomass production from wastewater containing diverse inorganic and organic nutrient species. © 2016 American Institute of Chemical Engineers Biotechnol. Prog., 32:1336–1342, 2016
Conceptualising the relationship between shopper religiosity, perceived risk and the role of moral potency
Authors: Baazeem Thamer , Mortimer Gary , Neale Larry
Published: June 2016

The primary aim of this paper is to conceptualise the influence of shopper religiosity on perceived risk and the moderating role of moral potency when purchasing religiously questionable products from retailers. An extensive review of extant literature was undertaken, drawing together the General Theory of Marketing Ethics and the concept of moral potency, in a retail context. A conceptual model is developed that provide the basis for future inquiry. The model elucidates the complex relationships between the dimensions of religiosity and social and psychological risk and then explains the moderating role of moral potency. The model offers a strong psychological explanation of how a shoppers' religion may increase their perceptions of risk in a purchase situation. The model also argues that risk perceptions may be heightened (or lessened) as a result of the shoppers' personal responsibility, confidence and courage. Retail managers may choose to implement this model in order to better predict shopper adoption behaviour of new religiously questionable products. The model allows for future empirical examinations across multiple shopping contexts and may be employed to estimate levels' demand for new products based on the extent of religiosity, moral potency and risk. The role of religion within retailing and shopping behaviour is emergent. Extant retailing literature has previously overlooked the role of religion as an antecedent to risk and the role of moral potency in moderating that relationship. This is the first paper to highlight these gaps and propose a testable model. Copyright © 2016 John Wiley & Sons, Ltd.
Choice confidence in the webrooming purchase process: The impact of online positive reviews and the motivation to touch
Authors: Flavián Carlos , Gurrea Raquel , Orús Carlos
Published: June 2016

The webrooming purchase process (i.e. searching for information online and then buying the product offline) is the most extended cross‐channel shopping behaviour. With the aim of offering a better understanding of this behaviour, this research relies on information processing and uncertainty reduction theories to propose that consumers use the online information to make the offline purchase with a higher degree of confidence. We examine the effects of a previous online interaction with a product on the preferences and decision at the physical store, as well as on the outcomes of the experience. In this path to purchase, we analyse how positive online customer reviews, as a specific form of electronic word of mouth, help the consumer to improve their experience, given their great potential to reduce the consumer's uncertainty in a purchase situation. In addition, the role of the motivation to touch the product is examined. The results of two studies show that the combination of an online search and an offline purchase improves the consumers' purchase experience in pre‐choice variables (i.e. purchase intentions), choice and post‐choice variables (i.e. search‐process satisfaction and choice confidence). Moreover, reading a positive online customer review influences choice confidence, and all the variables considered in the research when it is received at the physical store. Finally, the results stress the importance of the motivation to touch when studying multichannel shopping behaviour, given its direct and moderating effects on the webrooming purchase process. Implications for theory and practice are discussed. Copyright © 2016 John Wiley & Sons, Ltd.
Small Molecule Restores Itaconate Sensitivity in Salmonella enterica: A Potential New Approach to Treating Bacterial Infections
Authors: Hammerer Fabien , Chang Justin H. , Duncan Dustin , Castañeda Ruiz Angel , Auclair Karine
Published: June 2016

In the context of increasing global antibiotic resistance, the need for alternative therapeutic targets is great. Although new antibiotics and resistance inhibitors provide temporary solutions, they are bound to become obsolete. In this work, we propose a new approach, coined “bacterio‐modulation” that aims to restore macrophage potency towards bacterial strains that are able to survive in phagolysosomes. One key defense in the macrophage's arsenal is itaconate, an endogenous molecule with antimicrobial activity. Some intracellular pathogens have evolved to produce itaconate‐degrading enzymes, which are required for intracellular proliferation and to promote pathogenicity. We herein present the first molecule able to resensitize Salmonella enterica to itaconate.
Highly Sensitive Measurement of Inositol 1,4,5‐Trisphosphate by Using a New Fluorescent Ligand and Ligand Binding Domain Combination
Authors: Oura Tai , Murata Kaori , Morita Takao , Nezu Akihiro , Arisawa Mitsuhiro , Shuto Satoshi , Tanimura Akihiko
Published: June 2016

Based on the results of our previous adenophostin A structure–activity relationship studies, two fluorescent inositol 1,4,5‐trisphosphate (IP3) receptor ligands, fluorescent adenophostin A (FADA) and fluorescent low‐affinity ligand (FLL), were designed. Binding of the fluorescent ligands to the fluorescent IP3 sensor in protein‐expressing cells caused FRET. This principle was extended to a cell‐free assay system by using the fluorescent IP3 sensor bound to agarose beads. The effect of FLL on the FRET signal was reduced by subsequent addition of IP3. The IC50 values of IP3 on the FRET signals were 139.7 and 352.1 nm for 30 and 100 nm FLL, respectively. This method allowed quantitative measurement of IP3 concentrations below 10 nm and was applied to measure cytosolic IP3 concentrations in COS‐7 cells and to examine the potency of synthesized adenophostin A analogues.
Ac‐LPFFD‐Th: A Trehalose‐Conjugated Peptidomimetic as a Strong Suppressor of Amyloid‐β Oligomer Formation and Cytotoxicity
Authors: Sinopoli Alessandro , Giuffrida Alessandro , Tomasello Marianna Flora , Giuffrida Maria Laura , Leone Marilisa , Attanasio Francesco , Caraci Filippo , De Bona Paolo , Naletova Irina , Saviano Michele , Copani Agata , Pappalardo Giuseppe , Rizzarelli Enrico
Published: June 2016

The inhibition of amyloid formation is a promising therapeutic approach for the treatment of neurodegenerative diseases. Peptide‐based inhibitors, which have been widely investigated, are generally derived from original amyloid sequences. Most interestingly, trehalose, a nonreducing disaccharide of α‐glucose, is effective in preventing the aggregation of numerous proteins. We have determined that the development of hybrid compounds could provide new molecules with improved properties that might synergically increase the potency of their single moieties. In this work, the ability of Ac‐LPFFD‐Th, a C‐terminally trehalose‐conjugated derivative, to slow down the Aβ aggregation process was investigated by means of different biophysical techniques, including thioflavin T fluorescence, dynamic light scattering, ESI‐MS, and NMR spectroscopy. Moreover, we demonstrate that Ac‐LPFFD‐Th modifies the aggregation features of Aβ and protects neurons from Aβ oligomers' toxic insult.
Moving from Student Development to Student Success
Authors: Gillett‐Karam Rosemary
Published: June 2016

By using a reconstructionist and critical theory approach, a review of student development theories demonstrates the problematic nature of such ideas as they continue to be used to shape student affairs practice in community colleges.
College Impact Theories Past and Present
Authors: Ozaki C. Casey
Published: June 2016

This chapter critically examines the fit and applicability of foundational college impact theories to the community college context and students. Implications for the literature and campuses are explored.
Applying the Socio‐Ecological Outcomes Model to the Student Experiences of Men of Color
Authors: Harris Frank , Luke Wood J.
Published: June 2016

The authors of this chapter present the Socio‐Ecological Outcomes Model as a means of predicting student success for community college men of color.
Anticipating Practices and Theories in the Future
Authors: Spaid Robin L. , Casey Ozaki C.
Published: June 2016

The coeditors for this volume synthesize key propositions from the volume chapters and offer recommendations for community colleges to employ college impact theories in student affairs practice.
Site‐Selective Aliphatic C−H Silylation of 2‐Alkyloxazolines Catalyzed by Ruthenium Complexes
Authors: Kon Kazumasa , Suzuki Hiroyuki , Takada Kosuke , Kohari Yoshihito , Namikoshi Takeshi , Watanabe Shinji , Murata Miki
Published: June 2016

The Ru‐catalyzed dehydrogenative silylation of 2‐alkyloxazolines with 1,1,1,3,5,5,5‐heptamethyltrisiloxane took place site‐selectively at methyl C(sp3)−H bonds located γ to the nitrogen atom of the oxazolyl groups. Pyridine and pyrazole rings could also be used as a directing group. A catalytic mechanism based upon successive σ‐bond metathesis is proposed.
LiTi2(PO4)3/C Anode Material with a Spindle‐Like Morphology for Batteries with High Rate Capability and Improved Cycle Life
Authors: Yu Shicheng , Tempel Hermann , Schierholz Roland , Aslanbas Özgür , Gao Xin , Mertens Josef , de Haart Lambertus G. J. , Kungl Hans , Eichel Rüdiger‐A.
Published: June 2016

Nanocrystalline LiTi2(PO4)3/C has been synthesized by employing a solvothermal process in which oxalic acid was used as a solubilizer for the titanium source, a surfactant, and a carbon source. Additionally, Pechini's sol–gel‐based method was also used as the synthesis method for comparison. LiTi2(PO4)3/C prepared by using a solvothermal route showed a homogenous particle size with spindle‐like microstructures formed from self‐assembled nanosized‐platelets, whereas preparation by the sol–gel process resulted in agglomerated powders with irregular morphology and particle size. The different morphologies of LiTi2(PO4)3/C prepared in the two synthesis methods tend to form different electrode layer structures, which results in remarkable differences in their electrochemical properties. In particular, the solvothermally synthesized LiTi2(PO4)3/C composite exhibits superior high‐rate‐discharge capability and cycling stability. A capacity of approximately 97.7 % of the initial capacity was maintained for the solvothermal sample after 500 cycles at 5 C.
Solar Thermal Energy Storage in a Photochromic Macrocycle
Authors: Vlasceanu Alexandru , Broman Søren L. , Hansen Anne S. , Skov Anders B. , Cacciarini Martina , Kadziola Anders , Kjaergaard Henrik G. , Mikkelsen Kurt V. , Nielsen Mogens Brøndsted
Published: June 2016

The conversion and efficient storage of solar energy is recognized to hold significant potential with regard to future energy solutions. Molecular solar thermal batteries based on photochromic systems exemplify one possible technology able to harness and apply this potential. Herein is described the synthesis of a macrocycle based on a dimer of the dihydroazulene/vinylheptafulvene (DHA/VHF) photo/thermal couple. By taking advantage of conformational strain, this DHA–DHA macrocycle presents an improved ability to absorb and store incident light energy in chemical bonds (VHF–VHF). A stepwise energy release over two sequential ring‐closing reactions (VHF→DHA) combines the advantages of an initially fast discharge, hypothetically addressing immediate energy consumption needs, followed by a slow process for consistent, long‐term use. This exemplifies another step forward in the molecular engineering and design of functional organic materials towards solar thermal energy storage and release.
ChemInform Abstract: Crystal Structure Redetermination of ε‐Ni3Si2 from a Single Nanowire by Dynamical Refinement of Precession Electron Diffraction Data.
Authors: Correa Cinthia Antunes , Klementova Mariana , Drinek Vladislav , Kopecek Jaromir , Palatinus Lukas
Published: June 2016

Precession electron diffraction tomography (PEDT) is used to re‐determine the crystal structure of ε‐Ni3Si2 from a nanowire with a diameter of 35 nm.
ChemInform Abstract: Enhanced Thermoelectric Properties of Earth‐Abundant Cu2SnS3 via in Doping Effect.
Authors: Tan Qing , Sun Wei , Li Zhiliang , Li Jing‐Feng
Published: June 2016

Bulk samples of Cu2Sn1‐xInxS3 (x = 0—0.2) are prepared by mechanical alloying (450 rpm, 24 h) followed by spark plasma sintering in vacuum (873 K, 5 min).
ChemInform Abstract: Ce11Ge3.73(2)In6.27: Solid‐State Synthesis, Crystal Structure and Site‐Preference.
Authors: Jeon Beom‐Yong , Nam Gnu , Lee Dong Woo , Ok Kang Min , You Tae‐Soo
Published: June 2016

Bar‐shaped single‐crystals of Ce11Ge3.73In6.27 are prepared by solid state reaction of a 11:3:7 molar mixture of Ce, Ge, and In (sealed Nb ampoule in silica jacket, 950 °C, 2 d).
ChemInform Abstract: Symbiotic Transition‐Metal and Organocatalysis for Catalytic Ambient Amine Oxidation and Alkene Reduction Reactions.
Authors: Murray Alexander T. , King Rose , Donnelly Joseph V. G. , Dowley Myles J. H. , Tuna Floriana , Sells Daniel , John Matthew P. , Carbery David R.
Published: June 2016

A catalytic system of CuCl and alloxane is applied for the aerobic oxidative dimerization of benzylic amines (III) and cross‐coupling of amines (III) with anilines (V).
ChemInform Abstract: Iridium‐Catalyzed C—C Coupling of a Simple Propargyl Ether with Primary Alcohols: Enantioselective Homoaldol Addition via Redox‐Triggered (Z)‐Siloxyallylation.
Authors: Liang Tao , Zhang Wandi , Krische Michael J.
Published: June 2016

Ir‐catalyzed enantioselective C—C coupling of silylated propargyl ether (I) with alcohols (II) gives rise to γ‐hydroxy (Z)‐enol silanes (III), which can be readily converted into γ‐lactones (IV) and trisubstituted furans (V).
ChemInform Abstract: Palladium‐Catalyzed Enantioselective Domino Heck/Intermolecular C—H Bond Functionalization: Development and Application to the Synthesis of (+)‐Esermethole.
Authors: Kong Wangqing , Wang Qian , Zhu Jieping
Published: June 2016

A series of oxindoles (III) is obtained by a Pd‐catalyzed reaction of triflates (I) with oxadiazoles (II).
ChemInform Abstract: Enantioselective Synthesis of 3,5,6‐Substituted Dihydropyranones and Dihydropyridinones Using Isothiourea‐Mediated Catalysis.
Authors: Stark Daniel G. , Morrill Louis C. , Cordes David B. , Slawin Alexandra M. Z. , O'Riordan Timothy J. C. , Smith Andrew D.
Published: June 2016

The title compounds are synthesized from N‐tosyliminoacrylates and aroylacrylates by a Michael addition‐lactamization/lactonization cascade reaction.
ChemInform Abstract: Chain Walking as a Strategy for Carbon—Carbon Bond Formation at Unreactive Sites in Organic Synthesis: Catalytic Cycloisomerization of Various 1,n‐Dienes
Authors: Hamasaki Taro , Aoyama Yuka , Kawasaki Junichi , Kakiuchi Fumitoshi , Kochi Takuya
Published: June 2016

20 examples
ChemInform Abstract: Nucleophilic Substitution of the Hydroxyl Group in Stereogenic Alcohols with Chirality Transfer.
Authors: Bunrit Anon , Dahlstrand Christian , Srifa Pemikar , Olsson Sandra K. , Huang Genping , Biswas Srijit , Himo Fahmi , Samec Joseph S. M.
Published: June 2016

An intramolecular substitution of the OH group in enantioenriched alcohols is achieved by acid/base bifunctional catalysis.
ChemInform Abstract: An Eco‐Friendly, Hantzsch‐Based, Solvent‐Free Approach to 2‐Aminothiazoles and 2‐Aminoselenazoles.
Authors: Facchinetti Victor , Avellar Marcela M. , Nery Ana C. S. , Gomes Claudia R. B. , Vasconcelos Thatyana R. A. , de Souza Marcus V. N.
Published: June 2016

A very fast method for the synthesis of the title thiazoles and selenazoles through Hantzsch cyclization starting from thiourea and selenurea, resp., is developed.
ChemInform Abstract: Divergent Reactivity via Cobalt Catalysis: An Epoxide Olefination.
Authors: Jamieson Megan L. , Hume Paul A. , Furkert Daniel P. , Brimble Margaret A.
Published: June 2016

Cobalt‐catalyzed reaction of epoxides with dimethylsulfoxonium methylide provides a two‐carbon epoxide homologation/ring‐opening tandem process.
ChemInform Abstract: Towards a General Ruthenium‐Catalyzed Hydrogenation of Secondary and Tertiary Amides to Amines.
Authors: Cabrero‐Antonino Jose R. , Alberico Elisabetta , Junge Kathrin , Junge Henrik , Beller Matthias
Published: June 2016

A broad range of secondary and tertiary amides is hydrogenated to the corresponding amines under mild conditions using an in situ catalyst generated by combining [Ru(acac)3], 1,1,1‐tris(diphenylphosphinomethyl)ethane (Triphos) and Yb(OTf)3.
ChemInform Abstract: Silver(I)‐Catalyzed Iodination of Arenes: Tuning the Lewis Acidity of N‐Iodosuccinimide Activation.
Authors: Racys Daugirdas T. , Sharif Salaheddin A. I. , Pimlott Sally L. , Sutherland Andrew
Published: June 2016

A general method for the iodination of a wide range of arenes is developed.
ChemInform Abstract: Synthesis of Novel Imidazo[1,2‐a]pyridine‐4‐hydroxy‐2H‐coumarins by Groebke—Blackburn—Bienayme Multicomponent Reaction as Potential NS5B Inhibitors.
Authors: Manvar Parth , Shaikh Faraz , Kakadiya Rajesh , Mehariya Krunal , Khunt Ranjan , Pandey Bipin , Shah Anamik
Published: June 2016

A Groebke—Blackburn—Bienayme three component reaction of 4‐hydroxy‐3‐formylcoumarin, alkyl isocyanides, and 2‐aminoazines is demonstrated to give various imidazo[1,2‐a] fused heterocycles containing the coumarin scaffold.
ChemInform Abstract: Diastereoselective Synthesis of Tetrasubstituted Propargylamines via Hydroamination and Metalation of 1‐Alkynes and Their Enantioselective Conversion to Trisubstituted Chiral Allenes.
Authors: Periasamy Mariappan , Reddy Polimera Obula , Satyanarayana Iddum , Mohan Lakavathu , Edukondalu Athukuri
Published: June 2016

The reactions involve the diastereoselective addition of in situ formed alkynylcopper complexes to in situ formed iminium ions regioselectively affording the corresponding propargylamines.
ChemInform Abstract: Oxydifluoromethylation of Alkenes by Photoredox Catalysis: Simple Synthesis of CF2H‐Containing Alcohols.
Authors: Arai Yusuke , Tomita Ren , Ando Gaku , Koike Takashi , Akita Munetaka
Published: June 2016

The title reaction allows a single‐step and regioselective formation of C(sp3)—CF2H and C(sp3)—O bonds from C=C double bonds in terminal and internal alkenes, e.g. (I), (IV), (VI), and (VIII).
ChemInform Abstract: A General Method for the Synthesis of Enantiopure 1,5‐Amino Alcohols.
Authors: Guignard Guillaume , Llor Nuria , Urbina Aina , Bosch Joan , Amat Mercedes
Published: June 2016

Oxazolopiperidone lactams undergo an unprecedented reductive ring opening upon treatment with LiNH2BH3.
ChemInform Abstract: Visible Light‐Induced Iodine‐Catalyzed Transformation of Terminal Alkynes to Primary Amides via CC Bond Cleavage under Aqueous Conditions.
Authors: Dighe Shashikant U. , Batra Sanjay
Published: June 2016

This metal‐free protocol, which ensues via initial hydroamination of the acetylene bond, followed by release of CH2I2, is suitable for aromatic, heteroaromatic, and aliphatic alkynes.
ChemInform Abstract: A Palladium‐Catalyzed Three‐Component Synthesis of Arylmethylsulfonamides
Authors: Beisel Tamara , Manolikakes Georg
Published: June 2016

starting from various sulfonamides, arylboronic acids, and paraformaldehyde
ChemInform Abstract: Iron‐Catalyzed Synthesis of Arylsulfinates Through Radical Coupling Reaction.
Authors: Zhang Weixi , Luo Meiming
Published: June 2016

A novel strategy to insert sulfonyl fragment into arenes is accomplished via an iron‐catalyzed radical coupling reaction.
ChemInform Abstract: Catalytic Suzuki Couplings by an Amido Pincer Complex of Palladium.
Authors: Liang Lan‐Chang , Chien Pin‐Shu , Song Liang‐Hua
Published: June 2016

Noteworthy, the catalysis succeeds in the high yield production of sterically encumbered tri‐ortho‐substituted biaryls (VI).
ChemInform Abstract: Microwave Directed Metal‐Free Regiodivergent Synthesis of 1,2‐Teraryls and Study of Supramolecular Interactions.
Authors: Singh Surjeet , Shally Shally , Shaw Ranjay , Yadav Reena , Kumar Abhinav , Pratap Ramendra
Published: June 2016

The title compounds are prepared by ring transformation of pyrancarbonitriles by benzyl cyanides under basic conditions with moderate yields.
ChemInform Abstract: Concise Asymmetric Construction of C2‐Symmetric 1,9‐Diarylnonanoids Using a Hypervalent Silicon Complex: Total Synthesis of (‐)‐Ericanone.
Authors: Kotani Shunsuke , Kai Kosuke , Shimoda Yasushi , Hu Hao , Gao Shen , Sugiura Masaharu , Ogasawara Masamichi , Nakajima Makoto
Published: June 2016

Diarylnonanoids are concisely synthesized by phosphine oxide‐catalyzed enantioselective double aldol reaction in one step.
ChemInform Abstract: DDQ‐Mediated Oxidative Radical Cycloisomerization of 1,5‐Diynols: Regioselective Synthesis of Benzo[b]fluorenones under Metal‐Free Conditions.
Authors: Zhu Hui , Chen Zhiyuan
Published: June 2016

A synthesis of benzo[b]fluorenones via DDQ‐mediated oxidative cycloisomerization reaction of acyclic 1,5‐diynols is developed.
ChemInform Abstract: Cascade Pd(II)‐Catalyzed Wacker Lactonization—Heck Reaction: Rapid Assembly of Spiranoid Lactones.
Authors: Albarghouti Ghassan , Kotikalapudi Ramesh , Lankri David , Valerio Viviana , Tsvelikhovsky Dmitry
Published: June 2016

The new unprecedented Wacker—Heck lactonization‐cyclization reaction provides bi‐ and tricyclic spiranoid lactones in good yields.
ChemInform Abstract: 1,3‐Dipolar Cycloaddition Enabled Isoxazole‐Fused Spiropyrrolidine Oxindoles Syntheses from 3‐Methyl‐4‐nitro‐5‐alkenyl‐isoxazoles and Azomethine Ylides.
Authors: Liu Xiong‐Wei , Yao Zhen , Yang Jun , Chen Zhi‐Yong , Liu Xiong‐Li , Zhao Zhi , Lu Yi , Zhou Ying , Cao Yu
Published: June 2016

1,3‐Dipolar cycloaddition of in situ thermally generated azomethine ylides with alkenyl substituted isoxazoles offers a convenient synthesis of fused spiropyrrolidine oxindoles in good diastereoselectivity.
ChemInform Abstract: The Deep Eutectic Melt of Sorbitol and Metformin Hydrochloride: Synthesis of 3‐Substituted 2‐Aminonaphtho[2,3‐b]furan‐4,9‐diones and Their Photophysical Properties.
Authors: Rad‐Moghadam Kurosh , Mousazadeh Hassani Seyyed Ali Reza , Toorchi Roudsari Saeedeh
Published: June 2016

The title compounds are obtained in one‐pot by reaction of naphthoquinone, various β‐nitrostyrenes, and ammonium acetate using the deep eutectic melt as readily available, biocompatible, and easily recyclable catalytic system.
ChemInform Abstract: Iodine Mediated Intramolecular C2‐Amidative Cyclization of Indoles: A Facile Access to Indole Fused Tetracycles.
Authors: Badigenchala Sindhura , Rajeshkumar Venkatachalam , Sekar Govindasamy
Published: June 2016

A novel, metal‐free and efficient iodine mediated intramolecular sulfonamidation of indoles is reported which gives general access to different indole fused heterocycles.
ChemInform Abstract: Synthesis of Tetra‐Substituted 5‐Trifluoromethylpyrazoles via Sequential Halogenation/Palladium‐Catalyzed C—C and C—N Cross‐Coupling.
Authors: Wiethan Carson , Rosa Wilian C. , Bonacorso Helio G. , Stradiotto Mark
Published: June 2016

The new synthetically useful methodology to construct tetrasubstituted trifluoromethylpyrazoles involves halogenation of starting trifluoromethylpyrazoles, and subsequent palladium‐catalyzed Negishi coupling or Buchwald‐Hartwig amination with (hetero)arylzinc chlorides and primary alkylamines.
ChemInform Abstract: Conversion of Carbon Dioxide into 2‐Oxazolidinones and 2(3H)‐Oxazolones Catalyzed by 2,2′,2′′‐Terpyridine.
Authors: Liu Huixin , Hua Ruimao
Published: June 2016

2,2′,2′′‐Terpyridine is described as efficient catalyst for the three component reaction of propargyl alcohols, primary amines and CO2 to give oxazolidinone derivatives (IV) and (VI).
ChemInform Abstract: An Efficient and Tunable Route to Bis(1,2,3‐triazol‐1‐yl)methane‐Based Nitrogen Compounds.
Authors: Castro‐Osma Jose A. , Lara‐Sanchez Agustin , Otero Antonio , Rodriguez Ana M. , de la Torre Maria C. , Sierra Miguel A.
Published: June 2016

1,3‐Dipolar cycloaddition of geminal diazides with alkynes provides the title species (III) and (V).
ChemInform Abstract: A General Metal‐Free Route Towards the Synthesis of 1,2,3‐Triazoles from Readily Available Primary Amines and Ketones.
Authors: Thomas Joice , Jana Sampad , John Jubi , Liekens Sandra , Dehaen Wim
Published: June 2016

An unprecedented selective preparation of 1,5‐disubstituted 1,2,3‐triazoles from readily available primary amines, enolizable ketones and 4‐nitrophenyl azide as a renewable source of dinitrogen is developed.
ChemInform Abstract: A Binuclear Cu(I) Complex as a Novel Catalyst Towards the Direct Synthesis of N‐2‐Aryl‐substituted‐1,2,3‐triazoles from Chalcones.
Authors: Singh Divya Pratap , Allam Bharat Kumar , Singh Rahul , Singh Krishna Nand , Singh Vinod Prasad
Published: June 2016

The title triazoles are prepared by click reaction of chalcones and sodium azide followed by N‐arylation with (di)nitrohalobenzenes.
ChemInform Abstract: Bovine Serum Albumin Catalyzed One‐Pot, Three‐Component Synthesis of Dihydropyrano[2,3‐c]pyrazole Derivatives in Aqueous Ethanol.
Authors: Dalal Kiran S. , Tayade Yogesh A. , Wagh Yogesh B. , Trivedi Darshak R. , Dalal Dipak S. , Chaudhari Bhushan L.
Published: June 2016

An environmentally benign method for preparation of the title compounds by reaction of ketones/isatins/aldehydes with malononitrile and pyrazolone is developed.
ChemInform Abstract: Inherently Chiral Heterocyclic Resorcinarenes Using a Diels—Alder Reaction.
Authors: Iwanek W. , Stefanska K. , Szumna A. , Wierzbicki M.
Published: June 2016

The title compounds are prepared with unusually high diastereoselectivity in one‐pot via thermal generation of o‐quinomethide resorcinarene derivatives and subsequent Diels—Alder reaction with dienophiles, such as α‐methylstyrene.
ChemInform Abstract: Palladium‐Catalyzed Thioetherification of Quinolone Derivatives via Decarboxylative C—S Cross‐Couplings
Authors: Xia Chengcai , Wei Zhenjiang , Yang Yong , Yu Wenbo , Liao Hanxiao , Shen Chao , Zhang Pengfei
Published: June 2016

using diaryl disulfides
ChemInform Abstract: Copper‐Mediated Cross‐Dehydrogenative Coupling of 2‐Methylpyridine and 8‐Methylquinoline with Methyl Ketones and Benzamides.
Authors: Kumar Gadde Sathish , Boyle Joshua William , Tejo Ciputra , Chan Philip Wai Hong
Published: June 2016

Methyl ketones as coupling partners seem to react via an aldehyde intermediate, whereas benzamides and an aniline derivatives seem to react via a radical mediated process.
ChemInform Abstract: A Simple, Efficient and Solvent‐Free Reaction for the Synthesis of Quinolines Using Caesium Iodide.
Authors: Mokhtarpour Nazanin , Eshghi Hossein , Bakavoli Mehdi , Eshkil Fatemeh
Published: June 2016

The new method has the advantages of good yields, a clean reaction, simple methodology, short reaction times, easy work‐up and green conditions.
ChemInform Abstract: Nano‐NiFe2O4 Catalyzed Microwave Assisted One‐Pot Regioselective Synthesis of Novel 2‐Alkoxyimidazo[1,2‐a]pyridines under Aerobic Conditions
Authors: Payra Soumen , Saha Arijit , Banerjee Subhash
Published: June 2016

starting from 2‐aminopyridine, β‐nitrostyrenes, and various alcohols
ChemInform Abstract: Multicomponent Cascade Reaction: Dual Role of Copper in the Synthesis of 1,2,3‐Triazole Tethered Benzimidazo[1,2‐a]quinoline and Their Photophysical Studies.
Authors: Nagesh Hunsur Nagendra , Suresh Amaroju , Reddy Muthyala Nagarjuna , Suresh Narva , Subbalakshmi Jayanty , Chandra Sekhar Kondapalli Venkata G.
Published: June 2016

The title compounds are prepared from (azidomethyl)benzimidazoles, acetylenes, and benzaldehydes by domino/cascade reaction including click reaction, N—C bond formation, and Knoevenagel condensation.
ChemInform Abstract: Gold‐Catalyzed Chemo‐ and Diastereoselective C(sp2)—H Functionalization of Enaminones for the Synthesis of Pyrrolo[3,4‐c]‐quinolin‐1‐one Derivatives.
Authors: Zhao Yulei , Duan Qizhao , Zhou Yuanyuan , Yao Qiyi , Li Yanzhong
Published: June 2016

Novel one‐pot procedure for the synthesis of pyrrolo[3,4‐c]‐quinolinones starting from enaminones and diazo compounds by sequential addition of the Au(I) catalyst and TosOH under mild reaction conditions is developed.
ChemInform Abstract: Mechanistic Insights into a Catalyst‐Free Method to Construct Quinazolinones Through Multiple Oxidative Cyclization.
Authors: Wang Zhen‐zhen , Tang Yu
Published: June 2016

An oxidative cyclization of 2‐aminobenzamides with benzylic alcohols is developed to give varying yields of 2‐acylated quinazolinones in the presence of elemental oxygen as terminal oxidant.
ChemInform Abstract: First Catalytic Asymmetric Hydrogenation of Quinoxaline‐2‐carboxylates.
Authors: Maj Anna M. , Heyte Svetlana , Araque Marcia , Dumeignil Franck , Paul Sebastien , Suisse Isabelle , Agbossou‐Niedercorn Francine
Published: June 2016

The catalytic hydrogenation of alkyl quinoxaline‐2‐carboxylates is studied under continuous flow conditions in the presence of in situ generated Ir‐catalyst but the resulting ee′s are rather low.
ChemInform Abstract: Access to the 2H‐Tetrahydro‐4,6‐dioxo‐1,2‐oxazine Ring System from Nitrone via a Tandem Nucleophilic Addition and Transesterification Reaction.
Authors: Yang Shaoqiang , Liao Daohong , Tian Xiaoqi , Lei Xiaoguang
Published: June 2016

The first general route to the title oxazine ring system, a heterocyclic scaffold found in the complex natural products alchivemycin A and B, is given.
ChemInform Abstract: Efficient and Convenient Synthesis, Characterization, and Antimicrobial Evaluation of Some New Tetracyclic 1,4‐Benzothiazines.
Authors: Mor Satbir , Nagoria Savita
Published: June 2016

Among the tested tetracyclic 1,4‐benzothiazines (III), compounds (IIIg) and (IIIh) are found to be more potent than the standard drugs against A.
ChemInform Abstract: Multicomponent Synthesis of Cyclic Depsipeptide Mimics by Ugi Reaction Including Cyclic Hemiacetals Derived from Asymmetric Organocatalysis.
Authors: de la Torre Alexander F. , Rivera Daniel G. , Concepcion Odette , Echemendia Radell , Correa Arlene G. , Paixao Marcio W.
Published: June 2016

Polysubstituted nine‐membered‐ring lactones are prepared by Ugi reaction of enantiomerically enriched cyclic hemiacetals with a wide range of α‐amino acids and isocyanides of aliphatic, peptidic, glycosidic, and lipidic nature.
ChemInform Abstract: Copper‐Catalyzed Borylation of Cyclic Sulfamidates: Access to Enantiomerically Pure (β‐and γ‐Aminoalkyl)boronic Esters.
Authors: Ursinyova Nina , Bedford Robin B. , Gallagher Timothy
Published: June 2016

It is proposed, that a N‐sulfated iodide is the key intermediate in the borylation reaction of cyclic sulfonamides.
ChemInform Abstract: TBAI‐Catalyzed Oxidative C—H Functionalization: A New Route to Benzo[b]phosphole Oxides.
Authors: Zhang Yun , Hu Gaobo , Ma Dumei , Xu Pengxiang , Gao Yuxing , Zhao Yufen
Published: June 2016

The first simple and efficient TBAI‐catalyzed addition/cyclization of toluene derivatives with diaryl(arylethynyl)phosphine oxides, furnishing rapid access to a structurally diverse array of benzo[b]phosphole oxides via sequential Csp3—H/Csp2—H functionalization with remarkable functional group tolerance and good to excellent yields is developed.
ChemInform Abstract: Room‐Temperature Alkynylation of Phosphine Oxides with Copper Acetylides: Practical Synthesis of Alkynylphosphine Oxides.
Authors: Gerard Phideline , Veillard Romain , Alayrac Carole , Gaumont Annie‐Claude , Evano Gwilherm
Published: June 2016

Upon simple activation with molecular oxygen at room temperature copper acetylides are shown to be convenient reagents for the alkynylation of sencondary phosphine oxides.
ChemInform Abstract: Enantioselective Total Synthesis of the Proposed Structure of the Endophytic Fungal Metabolite Phomolide G: Structural Revision and Unambiguous Stereochemical Assignment.
Authors: McNulty James , McLeod David , Jenkins Hilary A.
Published: June 2016

The synthesis of the proposed structure of phomolide G (I) from L‐tartaric acid shows significant differences in the NMR data with the natural product.
ChemInform Abstract: Cipacinoids A—D, Four Limonoids with Spirocyclic Skeletons from Cipadessa cinerascens.
Authors: Yu Jin‐Hai , Liu Qun‐Fang , Sheng Li , Wang Guo‐Cai , Li Jia , Yue Jian‐Min
Published: June 2016

Cipacinoids A (I) shows moderate protein tyrosine phosphatase 1B inhibition.
ChemInform Abstract: Nitrogen‐Doped Titanium Dioxide (N‐Doped TiO2) for Visible Light Photocatalysis
Authors: Ansari Sajid Ali , Khan Mohammad Mansoob , Ansari Mohd Omaish , Cho Moo Hwan
Published: June 2016

Review: 67 refs.
ChemInform Abstract: Metal Chalcogenide Quantum Dots: Biotechnological Synthesis and Applications
Authors: Mal J. , Nancharaiah Y. V. , van Hullebusch E. D. , Lens P. N. L.
Published: June 2016

Review: 201 refs.
ChemInform Abstract: Graphene‐Based Artificial Nacre Nanocomposites
Authors: Zhang Yuanyuan , Gong Shanshan , Zhang Qi , Ming Peng , Wan Sijie , Peng Jingsong , Jiang Lei , Cheng Qunfeng
Published: June 2016

Review: tutorial review; 55 refs.
ChemInform Abstract: New Perspectives in Organolanthanide Chemistry from Redox to Bond Metathesis: Insights from Theory
Authors: Kefalidis Christos E. , Castro Ludovic , Perrin Lionel , Rosal Iker Del , Maron Laurent
Published: June 2016

Review: [a fifteen year contribution of computation studies in close synergy with experiments; 262 refs.
ChemInform Abstract: Textile Catalysts — An Unconventional Approach Towards Heterogeneous Catalysis
Authors: Mayer‐Gall Thomas , Lee Ji‐Woong , Opwis Klaus , List Benjamin , Gutmann Jochen S.
Published: June 2016

Review: [16 refs.
ChemInform Abstract: Umpolung Reactions of α‐Imino Esters: Useful Methods for the Preparation of α‐Amino Acid Frameworks
Authors: Mizota Isao , Shimizu Makoto
Published: June 2016

Review: [44 refs.
ChemInform Abstract: Recent Progress in Synthesis and Application of Thiophene Oligomers Based on Bithiophene Dicarbanions
Authors: Li Lu , Zhao Chunmei , Wang Hua
Published: June 2016

Review: [30 refs.
ChemInform Abstract: Synthesis and Applications of π‐Extended Naphthalene Diimides
Authors: Li Cheng , Lin Zhi , Li Yan , Wang Zhaohui
Published: June 2016

Review: [34 refs.
ChemInform Abstract: Asymmetric Synthesis of Chiral Atropisomeric Bis‐Aryl Organophosphorus from Menthyl H‐Phosphinate
Authors: Ma Yan‐Na , Yang Shang‐Dong
Published: June 2016

Review: [21 refs.
ChemInform Abstract: Synthesis of Amaryllidaceae Constituents and Unnatural Derivatives
Authors: Ghavre Mukund , Froese Jordan , Pour Milan , Hudlicky Tomas
Published: June 2016

Review: [recent total syntheses of the title natural products and structure—activity relationships; 187 refs.
ChemInform Abstract: Asymmetric Catalysis Powered by Chiral Cyclopentadienyl Ligands
Authors: Newton Christopher G. , Kossler David , Cramer Nicolai
Published: June 2016

Review: [40 refs.
ChemInform Abstract: Ring‐Substitution, Enlargement, and Contraction by Base‐Induced Rearrangements of N‐Heterocyclic Ammonium Salts
Authors: Tayama Eiji
Published: June 2016

Review: [67 refs.
ChemInform Abstract: High‐Valent‐Cobalt‐Catalyzed C—H Functionalization Based on Concerted Metalation—Deprotonation and Single‐Electron‐Transfer Mechanisms
Authors: Wei Donghui , Zhu Xinju , Niu Jun‐Long , Song Mao‐Ping
Published: June 2016

Review: [61 refs.
ChemInform Abstract: Synthesis of Heterocyclic Scaffolds Through 6‐Aminouracil‐Involved Multicomponent Reactions
Authors: Mohammadi Ziarani Ghodsi , Hosseini Nasab Narges , Lashgari Negar
Published: June 2016

Review: 98 refs.
ChemInform Abstract: Properties and Reactivity of Nucleic Acids Relevant to Epigenomics, Transcriptomics, and Therapeutics
Authors: Gillingham Dennis , Geigle Stefanie , Anatole von Lilienfeld O.
Published: June 2016

Review: 234 refs.
ChemInform Abstract: The Elasticity of MOFs under Mechanical Pressure
Authors: Yang Ke , Zhou Guanglin , Xu Quan
Published: June 2016

Review: 44 refs.
ChemInform Abstract: Quinoxaline‐Based Scaffolds Targeting Tyrosine Kinases and Their Potential Anticancer Activity
Authors: El Newahie Aliya M. S. , Ismail Nasser S. M. , Abou El Ella Dalal A. , Abouzid Khaled A. M.
Published: June 2016

Review: 116 refs.
ChemInform Abstract: Design of a Confined Environment Using Protein Cages and Crystals for the Development of Biohybrid Materials
Authors: Abe Satoshi , Maity Basudev , Ueno Takafumi
Published: June 2016

Review: 130 refs.
ChemInform Abstract: Molecular Design for Cryogenic Magnetic Coolants
Authors: Liu Jun‐Liang , Chen Yan‐Cong , Tong Ming‐Liang
Published: June 2016

Review: [20 refs.
ChemInform Abstract: Poly(vinyl alcohol): Review of Its Promising Applications and Insights into Biodegradation
Authors: Ben Halima Nihed
Published: June 2016

Review: 94 refs.
ChemInform Abstract: Lignin‐Based Thermoplastic Materials
Authors: Wang Chao , Kelley Stephen S. , Venditti Richard A.
Published: June 2016

Review: [approaches towards the development and chemical modification; 72 refs.
Combinatorial Library Screening Coupled to Mass Spectrometry to Identify Valuable Cyclic Peptides
Authors: Camperi Silvia A. , Giudicessi Silvana L. , Martínez‐Ceron María C. , Gurevich‐Messina Juan M. , Saavedra Soledad L. , Acosta Gerardo , Cascone Osvaldo , Erra‐Balsells Rosa , Albericio Fernando
Published: June 2016

Combinatorial library screening coupled to mass spectrometry (MS) analysis is a practical approach to identify useful peptides. Cyclic peptides can have high biological activity, selectivity, and affinity for target proteins, and high stability against proteolytic degradation. Here we describe two strategies to prepare combinatorial libraries suitable for MS analysis to accelerate the discovery of cyclic peptide structures. Both approaches use ChemMatrix resin and the linker 4‐hydroxymethylbenzoic acid. One strategy involves the synthesis of a one‐bead–two‐peptides library in which each bead contains both the cyclic peptide and its linear counterpart to facilitate MS analysis. The other protocol is based on the synthesis of a cyclic depsipeptide library in which a glycolamidic ester group is incorporated by adding glycolic acid. After library screening, the ring is opened and the peptide is released simultaneously for subsequent MS analysis. © 2016 by John Wiley & Sons, Inc.
Using Time‐Dependent Density Functional Theory to Probe the Nature of Donor–Acceptor Stenhouse Adduct Photochromes
Authors: Laurent Adèle D. , Medveď Miroslav , Jacquemin Denis
Published: June 2016

The front cover artwork is provided by University of Nantes (France) and Matel Bel University in Banská Bystrica (Slovakia). The image shows the vibrationally‐resolved spectra of the open DASA isomer. Read the full text of the article at 10.1002/cphc.201600041.