bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of imaging biomarkers from body composition analysis on outcome of endovascularly treated acute ischemic stroke patients
Authors: Styczen Hanna , Maus Volker , Weiss Daniel , Goertz Lukas , Hosch René , Rubbert Christian , Beck Nikolas , Holtkamp Mathias , Salhöfer Luca , Schubert Rosa , Deuschl Cornelius , Nensa Felix , Haubold Johannes
Published: September 2024

Background

We investigate the association of imaging biomarkers extracted from fully automated body composition analysis (BCA) of computed tomography (CT) angiography images of endovascularly treated acute ischemic stroke (AIS) patients regarding angiographic and clinical outcome.

Methods

Retrospective analysis of AIS patients treated with mechanical thrombectomy (MT) at three tertiary care-centers between March 2019–January 2022. Baseline demographics, angiographic outcome and clinical outcome evaluated by the modified Rankin Scale (mRS) at discharge were noted. Multiple tissues, such as muscle, bone, and adipose tissue were acquired with a deep-learning-based, fully automated BCA from CT images of the supra-aortic angiography.

Results

A total of 290 stroke patients who underwent MT due to cerebral vessel occlusion in the anterior circulation were included in the study. In the univariate analyses, among all BCA markers, only the lower sarcopenia marker was associated with a poor outcome (P=0.007). It remained an independent predictor for an unfavorable outcome in a logistic regression analysis (OR 0.6, 95% CI 0.3 to 0.9, P=0.044). Fat index (total adipose tissue/bone) and myosteatosis index (inter- and intramuscular adipose tissue/total adipose tissue*100) did not affect clinical outcomes.

Conclusion

Acute ischemic stroke patients with a lower sarcopenia marker are at risk for an unfavorable outcome. Imaging biomarkers extracted from BCA can be easily obtained from existing CT images, making it readily available at the beginning of treatment. However, further research is necessary to determine whether sarcopenia provides additional value beyond established outcome predictors. Understanding its role could lead to optimized, individualized treatment plans for post-stroke patients, potentially improving recovery outcomes.
ZigZagFuzz: Interleaved Fuzzing of Program Options and Files
Authors: Lee Ahcheong , Choi Youngseok , Hong Shin , Kim Yunho , Cho Kyutae , Kim Moonzoo
Published: September 2024

Command-line options (e.g.,
-l
,
-F
,
-R
for
ls
) given to a command-line program can significantly alternate the behaviors of the program. Thus, fuzzing not only file input but also program options can improve test coverage and bug detection. In this article, we propose ZigZagFuzz which achieves higher test coverage and detects more bugs than the state-of-the-art fuzzers by separately mutating program options and file inputs in an iterative/interleaving manner. ZigZagFuzz applies the following three core ideas. First, to utilize different characteristics of the program option domain and the file input domain, ZigZagFuzz separates phases of mutating program options from ones of mutating file inputs and performs two distinct mutation strategies on the two different domains. Second, to reach deep segments of a target program that are accessed through an interleaving sequence of program option checks and file inputs checks, ZigZagFuzz continuously interleaves phases of mutating program options with phases of mutating file inputs. Finally, to improve fuzzing performance further, ZigZagFuzz periodically shrinks input corpus by removing similar test inputs based on their function coverage. The experiment results on the 20 real-world programs show that ZigZagFuzz improves test coverage and detects 1.9 to 10.6 times more bugs than the state-of-the-art fuzzers that mutate program options such as AFL++-argv, AFL++-all, Eclipser, CarpetFuzz, ConfigFuzz, and POWER. We have reported the new bugs detected by ZigZagFuzz, and the original developers confirmed our bug reports.
Label Distribution Guided Hashing for Cross-Modal Retrieval
Authors: Lei Fatang , Zhang Chao , Li Huaxiong , Gao Yang , Chen Chunlin
Published: September 2024

Hashing methods have recently attracted extensive attention in cross-modal retrieval. Most supervised hashing methods attempt to preserve the semantic information into hash codes by leveraging the original logical label matrix. However, they generally treat all labels equally, and ignore the relative significance of different labels due to the variety of data features. In this article, we argue that exploring the relative importance of labels benefits the enhancement of semantic information, and we propose a novel LAbel Distribution Guided Hashing (LADH) method for cross-modal retrieval. In particular, LADH first learns a feature-induced label distribution for each sample to weigh different labels, which leverages the multi-modal feature information to enrich the semantic label information. By jointly using the learned label distributions and multi-modal features, the latent representation and hash codes are obtained with multi-modal feature selection and enhanced semantic similarities embedded. An efficient algorithm is designed to solve the proposed method whose time complexity is linear to the number of the training instances. Experimental results on several public benchmark datasets verify the effectiveness and efficiency of our method compared with the state-of-the-art methods.
Phosphodiesterases: Evolving Concepts and Implications for Human Therapeutics
Authors: Kelly Evan D. , Ranek Mark J. , Zhang Manling , Kass David A. , Muller Grace K.
Published: September 2024

Phosphodiesterases (PDEs) are a superfamily of enzymes that hydrolyze cyclic nucleotides. While the 11 PDE subfamilies share common features, key differences confer signaling specificity. The differences include substrate selectivity, enzymatic activity regulation, tissue expression, and subcellular localization. Selective inhibitors of each subfamily have elucidated the protean role of PDEs in normal cell function. PDEs are also linked to diseases, some of which affect the immune, cardiac, and vascular systems. Selective PDE inhibitors are clinically used to treat these specific disorders. Ongoing preclinical studies and clinical trials are likely to lead to the approval of additional PDE-targeting drugs for therapy in human disease. In this review, we discuss the structure and function of PDEs and examine current and evolving therapeutic uses of PDE inhibitors, highlighting their mechanisms and innovative applications that could further leverage this crucial family of enzymes in clinical settings.
Haptic Perception and Its Relation to Action
Authors: Klatzky Roberta L.
Published: September 2024

Haptic perception uses signals from touch receptors to detect, locate, and mentally represent objects and surfaces. Research from behavioral science, neuroscience, and computational modeling advances understanding of these essential functions. Haptic perception is grounded in neural circuitry that transmits external contact to the brain via increasingly abstracted representations. Computational models of mechanical interactions at the skin predict peripheral neural firing rates that initiate the processing chain. Behavioral phenomena and associated neural processes illustrate the reciprocal relationship by which perception supports action and action gates experience. The interaction of sensation and action is evident in how features of surfaces and objects such as softness and curvature are encoded. By incorporating touch sensations in conjunction with motor control, biologically embedded prosthetics enhance user capabilities and may elicit feelings of ownership. Efforts to create virtual haptic experience with advanced technologies underscore the complexity of this fundamental perceptual channel and its relation to action.
Alexithymia: Toward an Experimental, Processual Affective Science with Effective Interventions
Authors: Luminet Olivier , Nielson Kristy A.
Published: September 2024

Alexithymia is a multi-dimensional personality trait involving difficulty identifying feelings, difficulty describing feelings, and an externally oriented thinking style. Poor fantasy life is debated as another facet. For over 50 years, the alexithymia literature has examined how alexithymia-related disturbances in perceiving and expressing feelings contribute to mental and physical disorders. We review the current understanding of alexithymia—including its definition, etiology, measurement, and vulnerabilities for both mental and physical illness—and its treatment. We emphasize the importance of further experimental and processual affective science research that (a) emphasizes facet-level analysis toward an understanding of the nuanced bases of alexithymia effects on neural, cognitive, and behavioral processes; (b) distinguishes between emotion deficits and emotion over-responding, including when over-responding is functional; and (c) clarifies when and how impairments occur for neutral and positively valenced information or contexts. Taken as a whole, a clarification of these issues will provide clear directions for effective and tailored alexithymia interventions.
Test-retest reliability of exercise blood pressure and the workload-indexed systolic blood pressure slope in healthy males and females
Authors: Hilton Sydney E. , Rycroft Alise D. , Matharu Tanvir S. , Khangura Pardeep K. , Bommarito Julian C. , Rocha Leilani C. , Stapleton Rileigh K. , Nardone Massimo , Millar Philip J.
Published: September 2024

Limited work has assessed the reliability of exercise blood pressure (BP) in young healthy males and females. Our results demonstrate that systolic BP test-retest reliability did not differ between submaximal and maximal exercise. Sex-specific analysis found that females had higher reliability in exercise systolic BP than males. Despite the acceptable average reliability, exercise BP measured using automated auscultation possesses wide confidence intervals, which impact sample size requirements in future trials.
Redox signaling in the pancreas in health and disease
Authors: Sastre Juan , Pérez Salvador , Sabater Luis , Rius-Pérez Sergio
Published: September 2024

This review addresses oxidative stress and redox signaling in the pancreas under healthy physiological conditions as well as in acute pancreatitis, chronic pancreatitis, pancreatic cancer, and diabetes. Physiological redox homeodynamics is maintained mainly by NRF2/KEAP1, NF-κB, protein tyrosine phosphatases, peroxisome proliferator-activated receptor-γ coactivator 1α (PGC1α), and normal autophagy. Depletion of reduced glutathione (GSH) in the pancreas is a hallmark of acute pancreatitis and is initially accompanied by disulfide stress, which is characterized by protein cysteinylation without increased glutathione oxidation. A cross talk between oxidative stress, MAPKs, and NF-κB amplifies the inflammatory cascade, with PP2A and PGC1α as key redox regulatory nodes. In acute pancreatitis, nitration of cystathionine-β synthase causes blockade of the transsulfuration pathway leading to increased homocysteine levels, whereas p53 triggers necroptosis in the pancreas through downregulation of sulfiredoxin, PGC1α, and peroxiredoxin 3. Chronic pancreatitis exhibits oxidative distress mediated by NADPH oxidase 1 and/or CYP2E1, which promotes cell death, fibrosis, and inflammation. Oxidative stress cooperates with mutant KRAS to initiate and promote pancreatic adenocarcinoma. Mutant KRAS increases mitochondrial reactive oxygen species (ROS), which trigger acinar-to-ductal metaplasia and progression to pancreatic intraepithelial neoplasia (PanIN). ROS are maintained at a sufficient level to promote cell proliferation, while avoiding cell death or senescence through formation of NADPH and GSH and activation of NRF2, HIF-1/2α, and CREB. Redox signaling also plays a fundamental role in differentiation, proliferation, and insulin secretion of β-cells. However, ROS overproduction promotes β-cell dysfunction and apoptosis in type 1 and type 2 diabetes.
Exploring the Influence of Demographic Factors and Flourishing on Workplace Distractions: A Cross‐Country Analysis
Authors: Shdaifat Emad , Shudayfat Tamadur , Al-Shdayfat Noha , Alotaibi Nora , Alduhaileb Mona
Published: September 2024

Objective: To explore the influence of demographic factors and flourishing on workplace distractions in a cross‐country analysis of Saudi Arabia and Jordan.

Methods: This cross‐sectional comparative study was conducted in two government hospitals: one in eastern Saudi Arabia and the other in northern Jordan. Data were collected from the nurses using convenience sampling. The required sample size was determined using the G∗Power software, with a target of 242 nurses per country, resulting in 484 participants. Ultimately, the final sample consisted of 437 nurses: 222 from Saudi Arabia and 215 from Jordan. Two online instruments were used to collect data on the distractions and flourishing.

Results: The study found that “using the Internet” and “using the phone” were the most time‐consuming distractions among nurses, while “watching TV” was the least time‐consuming. There were significant associations between demographics and distractions, with participants from Saudi Arabia having lower distraction scores than participants from Jordan. Younger participants were more distracted than older participants, whereas male participants were more distracted than female participants were. Smokers and individuals with less expertise exhibit higher levels of distraction. Furthermore, degree of education was associated with higher levels of distraction. Nurses in Saudi Arabia experience a much greater loss of productivity due to distractions than their Jordanian counterparts. Regression analysis revealed that experience, “Mental and Physical Health” domain scores, smoking status, and educational level all highly predicted distraction levels among Saudi Arabian and Jordanian nurses, accounting for approximately 9.6% of the differences in distraction.

Conclusion: In this cross‐country study on workplace distractions among Saudi and Jordanian nurses, “using the Internet” and “using the phone” emerged as the most time‐consuming distractions. Younger age, male sex, smoking, and less experience are associated with higher distraction levels. Additionally, higher education levels were linked to increased distraction. Implementing employee flourishing activities can help reduce distractions and enhance productivity. This study offers valuable insights into improving nurses’ performance and well‐being.
Retained Foreign Body in the Breast Following a Motor Vehicle Collision: A Case Report
Authors: Bresciani Daniela , Tsai Jacqueline
Published: September 2024

Background: Unintentionally retained foreign bodies in the breast are a rare phenomenon. Most reported cases are iatrogenically derived from surgeries and procedures. Only a handful of reported cases refer to noniatrogenic causes, including bullets, a sewing needle, and a headscarf pin. However, there are no reports to date that describe a retained foreign body in the breast after a motor vehicle collision or a similar traumatic event or from a decorative steering wheel emblem decal.

Case Description: We report the case of a 25‐year‐old female who was involved in a motor vehicle collision with airbag deployment that led to a left breast retained foreign body, a steering wheel emblem decal. On presentation to the emergency room, she reported left chest pain associated with a puncture wound lateral to the left nipple. Imaging at that time was consistent with a metallic object embedded in the subcutaneous tissue of the left breast. Four months after the accident, the patient continued having daily burning pain in the associated area. As such, surgical excision was recommended, and wire‐localized excision of the foreign body was subsequently performed. Grossly, the foreign body appeared as a metallic object with rhinestones, which the patient confirmed was a decorative emblem decal that was on her steering wheel. The postoperative course was uncomplicated, and follow‐up examinations revealed resolution of the left breast pain.

Conclusions: This case underscores a unique presentation after a common accident—a retained foreign body in the breast after a motor vehicle collision—and its successful surgical intervention leading to a favorable postoperative course. Notably, the National Highway Traffic Safety Administration recently advised drivers against adding decorative emblem decals to their steering wheels for this reason. The case therefore highlights safety precautions that should be taken regarding the addition of this type of accessory.
Organic Aquaculture Regulation, Production, and Marketing: Current Status, Issues, and Future Prospects—A Systematic Review
Authors: Beg Mirza Masum , Roy Subha M. , Ramesh Pradeep , Moulick Sanjib , Tiyasha Tiyasha , Bhagat Suraj Kumar , Abdelrahman Hisham A.
Published: September 2024

The aquaculture industry will be crucial in helping the world’s food supply and keep up with the demand. Aquaculture, like agriculture, must expand and develop sustainably in all the countries to keep up with the rising demand for food. To this end, the aquaculture industry has forged new scientific and technological frontiers in pursuit of long‐term food security. Among these is organic aquaculture, whose distinctive protocol has great potential to advance aquaculture. Organic aquaculture is being explored for multiple reasons, encompassing the aim to minimize environmental footprints, fulfill escalating consumer appetites for seafood, and contend within the industry this paper endeavors to address the gaps in current literature by offering an exhaustive overview of various aspects of organic aquaculture. This encompasses its regulation, production methods, food quality, environmental impact, economic viability, as well as socioeconomic and marketing aspects. It is necessary to acquire more knowledge about organic farming techniques before switching over to organic aquaculture on a large scale. Organic regulation, production, food quality, economic performance, and social and marketing issues are at the top. This review found that consumers lack understanding of organic principles, and regulations are inconsistently applied. However, organic aquaculture promotes social equality by protecting producers’ rights to work without discrimination based on gender, race, or sexual orientation factors that ultimately boost the industry’s popularity. Organic aquaculture viability varies depending on factors like feed costs, fixed expenses, and the premium pricing sensitivity, making it unfeasible for certain species. However, from both societal and economic standpoints, organic aquaculture appears most suitable for implementation in developing nations.
Enhancement of the Performance of Switched Reluctance Generators in Low Wind Speed Conditions Using Advanced Tracking Techniques
Authors: Morais Lucas Diniz S. , Reis Marcio R. Cunha , Araujo Wanderson Rainer H. , Martins Marcella Scoczynski R. , Ribeiro Luiz Eduardo B. , Rodrigues Clóves Gonçalves , Coimbra Antonio Paulo , Calixto Wesley Pacheco
Published: September 2024

This paper presents a tracking method to improve the performance of switched reluctance generators in areas with low wind speeds. The main contribution of this work is the proposal of an advanced control system that employs dynamic tracking techniques to optimize the energy efficiency and response of the switched reluctance generators under various operating conditions. The methodology encompasses the construction of the generator, the development of a wind turbine model, and the coupling of the turbine with the switched reluctance generators. Simulations are conducted using real wind speed data to evaluate the use of switched reluctance generators in wind energy generation. The performance of the switched reluctance generators is improved by applying a tracking technique that operates on the converter’s turn‐off angle, which controls the generator’s switching. The tracking and optimization techniques implemented in this work maximize the performance of switched reluctance generators in wind energy generation, both in standalone and self‐excited operations. The results demonstrate that satisfactory wind energy generation can be achieved using the SRG, with wind speeds of 5.40 m/s producing approximately 1.5 kW without optimization and around 1.65 kW with optimization, reaching about 70% efficiency with a custom‐built generator. This makes the technology viable for regions characterized by low wind speeds.
A Simulation Analysis of the Slumping Failure of Unstable Rocks With a Weak Base
Authors: Zhou Yuntao , Chen Zhigao
Published: September 2024

Toppling and slumping are two common failure modes for unstable rocks with a weak base (WBURs). The toppling failure of a WBUR is controlled by the degree of inclination of the base. In contrast, the slumping failure of a WBUR is controlled by parameters such as the gradient of the base slope, the gradient of the base surface, the strength of the base, and the geometric dimensions of unstable rocks, leading to complex failure mechanisms. To investigate the effects of these parameters on the failure modes of a WBUR, this study built a two‐dimensional simulation model of a WBUR, which used the equivalent load to replace an unstable rock model and used the inclination value to distinguish between toppling and slumping failures. Moreover, this study proposed a simulation method that determined slumping failures based on the presence of a penetrating area in the contour maps of the maximum shear strain rate of the base slope. The failures of the base slope of a WBUR subjected to slumping failures can be divided into shallow, arc‐shaped and broken line‐shaped types. The slumping failures of a WBUR are influenced by parameters such as the gradient of the base slope, the gradient of the base surface, the base strength, and the geometric dimensions of the unstable rock. The inclination value of the unstable rock obtained through numerical simulations can be used to distinguish between topping failures (forward and backward toppling) and slumping failures of a WBUR.
Enhancing Graphene Oxide Production and Its Efficacy in Adsorbing Crystal Violet: An In‐Depth Study of Thermodynamics, Kinetics, and DFT Analysis
Authors: Bourachdi Soukaina El , El Ouadrhiri Faiçal , Moussaoui Fatima , Saleh Ebraheem Abdu Musad , Amri Abdelhay El , Althomali Raed H. , Kassem Asmaa F. , Moharam Marwa Mostafa , Ayub Ali raza , Husain Kakul , Hassan Ismail , Lahkimi Amal
Published: September 2024

The textile industry’s waste often contains excessive amounts of crystal violet (CV), leading to environmental concerns. Graphene oxide has been studied as a promising adsorbent for removing crystal violet, a cationic dye, from aqueous solutions. The study involved a comprehensive analysis of various experimental parameters, including initial concentration, pH, adsorbent mass, contact time, and temperature. Graphene oxide underwent thorough analysis using Fourier‐transform infrared spectroscopy (FTIR), X‐ray diffraction (XRD), scanning electron microscopy (SEM), and specific surface area determination via the Brunauer–Emmett–Teller (BET) method. Energy‐dispersive X‐ray spectroscopy (EDS) was also employed. This study aimed to optimize the synthesis yield of graphene oxide from graphite using the Hummers method and response surface methodology (RSM), achieving a yield of 106.14% with 5 g of KMnO4 and 1 g of NaNO3 for 8 hours. The graphene oxide was analyzed via FTIR, XRD, SEM, BET, pHpzc, and EDS. Optimal conditions for maximal adsorption included 0.016 g of graphene oxide, 18 minutes of contact time, pH 10, and a temperature of 25°C, resulting in a 97.38% reduction in crystal violet with a monolayer adsorption capacity of 470.78 mg/g. Kinetic data were best fitted by the pseudosecond‐order model, and the Langmuir isotherm accurately depicted adsorption. Thermodynamic analysis indicated spontaneous (ΔG° < 0) and exothermic (ΔH° < 0) crystal violet adsorption. Density functional theory (DFT) explored interactions between graphene oxide and crystal violet, supporting experimental findings and confirming graphene oxide’s efficacy as an adsorbent for crystal violet removal from aqueous solutions.
The Fish Feed Sector in Kenya, Uganda, Tanzania, and Rwanda: Current Status, Challenges, and Strategies for Improvement—A Comprehensive Review
Authors: Munguti Jonathan , Muthoka Mavindu , Chepkirui Mercy , Kyule Domitila , Obiero Kevin , Ogello Erick , Madalla Nazael A. , Kwikiriza Gerald
Published: September 2024

This review paper provides an in‐depth analysis of the current status, challenges, and strategies for improvement within the fish feed industry in East Africa, focusing on Kenya, Uganda, Tanzania, and Rwanda. Aquaculture production in these countries is experiencing steady growth, driven by increasing demand for fish and fish products for both nutritional and economic purposes. Despite the market facilitating the transition from extensive to semi‐intensive and moderately intensive farming systems across the four countries, the sector’s progress is hampered by a lack of sustainable, locally produced, high‐quality, and cost‐effective fish feeds tailored to different developmental stages of fish. Despite the evident need, there is a notable scarcity of comprehensive reviews addressing the regional perspective of fish feed due to heightened cross‐border trade driven by the soaring demand and increased installation of cages in Lake Victoria, as well as in inland dams and reservoirs. This paper addresses critical challenges, such as regional scarcity and limited access to quality feed ingredients, regulatory obstacles, insufficient quality control measures, infrastructure constraints, and a lack of awareness and understanding of feed management and formulation. To overcome these challenges, the paper recommends fostering collaboration to establish a robust regional fish feed supply chain, investing in research and development initiatives, advocating for policy reforms and regulatory support, and compliance with East African Community quality standards for fish feed. Moreover, there is an urgent need to enhance human resource capacity through training and extension services, promote public investment support, strengthen sector institutions and industry associations, conduct training and awareness programs for feed providers, and improve storage facilities to maintain feed quality. The paper provides policymakers with valuable insights to inform targeted interventions that will catalyze positive transformation within the fish feed industry in East Africa.
The Tumor Immune Microenvironment Drives Survival Outcomes and Therapeutic Response in an Integrated Molecular Analysis of Gastric Adenocarcinoma
Authors: Skubleny Daniel , Purich Kieran , McLean David R. , Martins-Filho Sebastiao N. , Buttenschoen Klaus , Haase Erika , McCall Michael , Ghosh Sunita , Spratlin Jennifer L. , Schiller Dan E. , Rayat Gina R.
Published: September 2024

Purpose:

We performed an integrated analysis of molecular classification systems proposed by The Cancer Genome Atlas (TCGA), the Asian Cancer Research Group (ACRG), and the tumor microenvironment (TME) score to identify which classification scheme(s) are most promising to pursue in subsequent translational investigations.

Experimental Design:

Supervised machine learning classifiers were created using 10-fold nested cross-validation for TCGA, ACRG, and TME subtypes and applied to 2,202 patients with gastric cancer from 11 separate publicly available datasets. Overall survival was assessed with a multivariable Cox proportional hazards model. A propensity score–matched analysis was performed to evaluate the subgroup effect of adjuvant chemotherapy on molecular subtypes. A public external cohort comprised of metastatic gastric cancer treated with immunotherapy was used to externally validate the molecular subtypes.

Results:

Classification models for TCGA, ACRG, and TME achieved an accuracy ± SD of 89.5% ± 0.04, 84.7% ± 0.04, and 89.3% ± 0.02, respectively. We identified the TME score as the only significantly prognostic classification system [HR, 0.54 (95% confidence interval [CI], 0.39–0.74); global Wald test P < 0.001]. In our subgroup analysis, patients who received adjuvant chemotherapy achieved greater survival with increasing TME score (HR, 0.47; 95% CI, 0.29–0.74; interaction P < 0.05). The combination of TME-high and microsatellite instability scores significantly outperformed microsatellite instability as a univariable predictor of immunotherapy response.

Conclusions:

We conclude that the TME score is a predominate driver of prognosis as well as chemotherapy- and immunotherapy-related outcomes in gastric cancer. This article provides a foundation for additional analyses and translational work.
Supplementary Figure 7 from MYC is Sufficient to Generate Mid-Life High-Grade Serous Ovarian and Uterine Serous Carcinomas in a p53-R270H Mouse Model
Authors: Blackman Alexandra , Rees Amy C. , Bowers Robert R. , Jones Christian M. , Vaena Silvia G. , Clark Madison A. , Carter Shelby , Villamor Evan D. , Evans Della , Emanuel Anthony J. , Fullbright George , O’Malley Matthew S. , Carpenter Richard L. , Long David T. , Spruill Laura S. , Romeo Martin J. , Orr Brian C. , Helke Kristi L. , Delaney Joe R.
Published: September 2024

MYC levels in syngeneic OvTrpMyc cell lines relative to human lines
Supplementary Figure 3 from Claudin-4 Modulates Autophagy via SLC1A5/LAT1 as a Mechanism to Regulate Micronuclei
Authors: Villagomez Fabian R. , Lang Julie , Rosario Fredrick J. , Nunez-Avellaneda Daniel , Webb Patricia , Neville Margaret , Woodruff Elizabeth R. , Bitler Benjamin G.
Published: September 2024

Metabolic enrichments
Figure 4 from MYC is Sufficient to Generate Mid-Life High-Grade Serous Ovarian and Uterine Serous Carcinomas in a p53-R270H Mouse Model
Authors: Blackman Alexandra , Rees Amy C. , Bowers Robert R. , Jones Christian M. , Vaena Silvia G. , Clark Madison A. , Carter Shelby , Villamor Evan D. , Evans Della , Emanuel Anthony J. , Fullbright George , O’Malley Matthew S. , Carpenter Richard L. , Long David T. , Spruill Laura S. , Romeo Martin J. , Orr Brian C. , Helke Kristi L. , Delaney Joe R.
Published: September 2024

Molecular histology of the OSE. A, An OvTrpMyc mouse at 16 months of age with clear OSE staining of p53 and MYC. B, The intra-abdominal tumor extracted from the mouse shown in A exhibited PAX8, p53, and MYC staining. C, A WT mouse at 12 months of age is negative for p53 or MYC staining in OSE. D, Example of an OvTrpMyc mouse with a region of negative OSE staining of p53 and MYC, at 12 months of age.
Figure 3 from MYC is Sufficient to Generate Mid-Life High-Grade Serous Ovarian and Uterine Serous Carcinomas in a p53-R270H Mouse Model
Authors: Blackman Alexandra , Rees Amy C. , Bowers Robert R. , Jones Christian M. , Vaena Silvia G. , Clark Madison A. , Carter Shelby , Villamor Evan D. , Evans Della , Emanuel Anthony J. , Fullbright George , O’Malley Matthew S. , Carpenter Richard L. , Long David T. , Spruill Laura S. , Romeo Martin J. , Orr Brian C. , Helke Kristi L. , Delaney Joe R.
Published: September 2024

Molecular histology of the fallopian fimbriae. A, A WT mouse at 12 months of age showing little p53 or MYC staining in the FTE. B, OvTrpMyc fallopian tube at 15 months of age, F135, exhibiting p53 and MYC staining within the FTE. C, An OvTrpMyc mouse at 12 months of age, with vacuolated fallopian fimbriae–positive for p53 and MYC. D, An OvTrpMyc mouse at 15 months of age, with features resembling STIC.
First record of the genus Systenus Loew (Diptera: Dolichopodidae) from Colombia, with description of four new species
Authors: RAMOS-PASTRANA YARDANY , MERCHAN-VARGAS GERALDINE LUCIA , SOARES MATHEUS M.M.
Published: September 2024

The genus Systenus Loew, 1857 (Dolichopodidae: Medeterinae) is recorded for the first time from Colombia through the description of four new species: S. bickeli sp. nov., S. colombiensis sp. nov., S. fuscus sp. nov. and S. grossus sp. nov. and by the record of five previously described species: S. beatae Naglis, S. flaviatus Naglis, S. maculipennis Bickel, S. naranjensis Bickel and S. parkeri Bickel. A key to the males, high resolution photographs and distribution map of the nine Colombian species are provided.
Conclusion
Authors: Makhloufi Lilia
Published: September 2024

The conclusion summarises the key approaches and findings of the book, which investigated urban heritage across various global contexts to understand the complexities of conservation, management and development in a globalised world. It outlines how the first half of the book focused on sustainability in historic cities and neighbourhoods, while the second half focused on architectural heritage and the integration of environmental considerations in building design. It argues that sustainable development, encompassing environmental, human and cultural aspects, is crucial for future urban life. In turn, it critiques the homogenizing effects of globalization on architecture and advocates for localised, culturally sensitive urban planning that prioritises the needs and values of local populations.
Effect of Suction and Injection on Peristaltic Flow of a Jeffrey Nano Fluid Through a Vertical Channel with Saffman Slips Condition at the Flexible Walls
Authors: Lakshmi R. , Kavitha A.
Published: September 2024

The peristaltic flow mechanism has recently gained special status among modern scientists, because of its wide range of uses in engineering and biomechanics, an object or medium is forced to move by a type of wave gesticulation called peristaltic transport that develops in tubular structures.
Multiple physiological liquids are transported using this natural process. The Jeffrey fluid model, which exhibits viscoelastic (linear) properties and gives rise to non-linear viscoelastic liquid considerations, has been explored by many researchers to examine various rheological properties.
It became important, especially in the lungs, to analyze how physiological fluid, like blood, moves through absorbent walls. The current study investigates the effect of suction and injection on the peristaltic flow of a Jeffrey nanofluid through a vertical channel with Saffman slip condition
at the flexible walls. After establishing the governing conservation equations, the resulting flow model is effectively simulated using the realistic assumptions of a long wavelength and a low Reynolds number. The temperature distributions, velocity, pressure rate per wavelength, and nanoparticles
concentration of the resulting flow problem have been solved analytically. The effects of all physical factors on temperature, velocity, concentration fields, pressure rate, frictional force, and pressure gradient are graphically examined using Wolfram MATHEMATICA software. By raising the
parameter of Brownian motion parameter and Grashof number values, the pressure rate is enhanced. The pressure rise is reduced by increasing the Jeffrey nanofluid parameter and the thermophoresis parameters values. In the case of frictional force, the opposite behavior is noticed.
Bio-Convection Eyring-Powell Hybrid Nanofluid Flow Over an Extended Sheet in the Existence of Chemical Reaction and Motile Microorganisms
Authors: Abdeen Wafaa S. , Rashad Ahmed M. , Mahdy A. , Elshehabey Hillal M.
Published: September 2024

This mathematical analysis aims to examine the behavior of gyroscopic microorganisms to depict their role in transferring mass and heat in a hybrid nanofluid magnetohydrodynamic (MHD) that contains microorganisms and nanoparticles Cu and Al2O3 while considering
water as the basic fluid flowing over an extended surface with a chemical reaction. The presence of microorganisms increases the stability of suspended nanoparticles due to the bioconvection. The partial differential equations and the boundary conditions governing the problem were converted
into ordinary differential equations with the help of some appropriate nondimensional transformations. The resulting equations were solved numerically using the MATLAB program function bvp4c. The effect of some important physical parameters on the profiles of velocity, concentration of nanoparticles,
temperature, and motile microorganisms was also studied graphically. The coefficient of skin friction, mass and heat transfere rate, and microorganism density are enhanced when the convection constant parameter is improved. While the existence of a chemical reaction weakens the rate of heat
transfere, it improves the coefficient of friction of the skin, the density of microorganisms, and the rate of mass transfer. A comparison was made between this work and previous works, and it was found that there is excellent agreement.
A Scientometric Study of Nano Encapsulated Phase Change Material (NEPCM): Trends and Categories
Authors: Ghalambaz Sepideh
Published: September 2024

Exploring sustainable energy solutions, Nano Encapsulated Phase Change Materials (NEPCM) have demonstrated significant potential in heat and mass transfer and thermal energy storage. A scientometric study investigated trends and categories in NEPCM research from 2002 to 2023, revealing
an exponential growth since 2005, peaking in 2021 with 66 publications. The study encompassed 397 records, refined to 343, with 94.5% being original research articles. China is leading in contributions with 123 publications (35.9%), followed by Saudi Arabia, with King Khalid University producing
31 publications. “Journal of Energy Storage” is the primary source with 40 publications (11.7%). Keyword analysis focused on phase change materials, nanoencapsulation, and thermal energy storage. The research was categorized into six segments, with Synthesis of Nanoparticles being
paramount (56%), and diverse computational techniques and Radiation’s impact on NEPCM performance also emphasized. 82% of studies in the “Enhancement” category showed increased heat transfer through techniques like Nanoencapsulation. Natural/Free Convection dominated “Convection
Type” research (46%), and Porous Media and Clear Flow were significant in “Medium Type,” contributing to 78%. This study unveils the growth, diverse methodologies, and applications in NEPCM, laying a foundation for future advancements in sustainable energy solutions.
Nonlinear Radiative Mixed Convective Flow of Fourth-Grade Tetra-Hybrid Nanomaterial Over a Horizontal Cylindrical Surface
Authors: Mkhatshwa M. P.
Published: September 2024

In this article, we investigate magnetized mixed convective flow and heat transfer scrutiny of fourth-grade tetrahybrid nanomaterial through a horizontal circular cylinder with variable fluid properties, convective heating and suction/blowing. Tiwari–Das model has been utilized
to construct the nanofluid model. Thermal transport evolution is characterized with the assistance of nonlinear radiation, heat source/sink, viscous and Joule dissipation. The governing equations are first converted into dimensionless form using appropriate similarity transformations, and
then solved numerically using the overlapping multi-domain spectral collocation method that utilizes the local linearization approach. Numerical outcomes that simulate upshots of cornerstone parameters on flow quantities, wall frictional factor and heat transmission rate are discussed. Based
on the obtained results, fluid flow is accelerated by material parameters but decelerated by the variable viscosity parameter, whereas the opposite effect is observed for the skin friction factor. Utilizing tetra-hybrid nanofluid, combined with nonlinear radiation, heat source, and variable
thermal conductivity, is crucial for enhancing thermal transfer. The rate of heat transport increases with higher Biot number, nonlinear radiation, heat sink, and variable thermal conductivity. The results have been compared with previously published work and have shown excellent agreement.
The considered flow problem finds relevance in thermal performance enhancement of the working fluid, and polymer manufacturing procedures in chemical engineering.
Determinants of Violence in  India: Role of Economic and  Ethnic Factors
Authors: Shukla Shashank Shekhar , Bhattacharya Kaushik
Published: September 2024

The article examines what type of individuals face violence in India. We specify and estimate a probit model where the probability that a person would face violence depends on several individual, regional and institutional variables. The empirical application of this model on the India Human Development Survey (IHDS) data set for the year 2011–2012 reveals the presence of an important interaction between economic and ethnic factors. We find that violence against a ‘backward’ social group increases when it becomes upwardly mobile. In the case of forward castes, a reverse pattern is seen. Among ethnic measures, fractionalisation turned out to be the most important one in our study. Polarisation turned out to be statistically significant only when regions affected by violent separatist or political movements were treated with a dummy variable. Interestingly, as predicted by Esteban and Ray (2011) , the Gini coefficient based on consumption did not turn out to be significant. Among other variables, political activism, access to sanitation and the number of adult males in a household were important determinants of susceptibility to violence. Ongoing feuds in the village and radical or separatist movements in a state also increased susceptibility to violence.

JEL Codes: Z13, Z18, D31, D74
The human dimension of smart cities: Examining antecedents of citizens’ smart city policy literacy
Authors: Lee Danbee , Kang Minsung Michael , Kim Hannah June
Published: September 2024

This study directs its focus toward the human aspect of smart cities, a domain that has received comparatively scant attention in the existing body of literature. Using policy literacy theory, encompassing the citizens’ perceptions regarding policies through the lens of their understanding, we delve into four predictors of smart city policy literacy, (1) demographics, (2) socioeconomic status, (3) geographic factors and (4) attitudes toward government. Using a national survey, we find that gender, age, income, education, marital status and the reputation of an organization are meaningfully associated with policy literacy. These findings underscore the nuanced nature of the human aspect, highlighting the significance of heterogeneous individual dispositions of smart cities. Against the backdrop of ongoing debates questioning the validity of a one-size-fits-all approach, our study embraces the multifaceted and personalized attributes of the citizenry, acknowledging the imperative role of the human dimension in designing smart cities.

Points for practitioners:

• Analyzing the policy literacy of citizens in the context of smart cities holds significant implications for public managers and officials, as it unveils the practical utilization of policies by service recipients.

• Leveraging policy literacy theory, this research investigates individuals’ smart city policy literacy and finds meaningful associations with gender, age, income, education, marital status and organizational reputation.

• Acknowledging the varied viewpoints on smart cities and the limitations of a uniform approach is essential for policymakers and practitioners. This underscores the necessity of placing equal emphasis on the human aspect, taking into account the personalized needs and preferences of citizens.
Gender Gaps in World Christianity: Membership, Participation, and Leadership
Authors: Zurlo Gina A.
Published: September 2024

This article presents findings from recent research that nuances gender gaps in World Christianity utilizing quantitative data on religious membership, participation, and leadership. The article outlines the assumptions and theories undergirding this project on global gender inequalities by utilizing data from the United Nations and World Economic Forum. It then presents original research that produced gendered data on church membership, participation, and leadership around the world, drawing from the World Christian Database, Pew Research Center, and World Values Survey. These data are put into conversation with national level gender gap data in Mongolia, Israel, Estonia, and Ghana to provide country-level examples of how data can be used to shed light on women’s challenges and opportunities both in society and the church. Without comprehensive quantitative data on women's experiences around the world, it is difficult to know what problems exist and how they can be addressed. Data from this project can be applied contextually to address the gendered dynamics of church life and interrogate unequal social norms that perpetuate women’s overlooked status in churches and societies worldwide.
The Asymmetric Temporal Rhythms of Anti-Consumption
Authors: Moraes Caroline , Istanbulluoglu Doga , García de Frutos Nieves , Magrizos Solon
Published: September 2024

This research draws upon qualitative data to empirically examine a theorisation of the temporal dimensions of social practices, and how anti-consumption destabilises and is destabilised by five dimensions: duration, tempo, sequence, synchronisation and periodicity. Our analytical themes highlight the emergence of what we term dissonant intervals, that is, temporal glitches that manifest in these temporal dimensions of social practices that are unsettled by anti-consumption. Where the social coordination of temporalities becomes challenging or even impossible due to the accrual of these dissonant intervals, this generates a micro-level asymmetric (i.e. uneven, unsettled) socio-temporal rhythm in daily life. We contribute the novel concepts of dissonant interval and asymmetric socio-temporal rhythm to sociological research on the temporalities of social practices. The significance of these concepts lies in their expansion of existing temporality vocabularies and imaginaries, their generative potential for future research and their implications for the promotion of environmentally sustainable practices.
Equity in Digital Health: Assessing Access and Utilization of Remote Patient Monitoring, Medical Apps, and Wearables in Underserved Communities
Authors: Adepoju Omolola , Dang Patrick , Nguyen Holly , Mertz Jennifer
Published: September 2024

This study examined access to, and use of remote patient monitoring (RPM), medical applications, and wearables in a racially diverse, lower-income population. Data were obtained via a cross-sectional survey of adults from low-income communities in Houston, Los Angeles, and New York between April and August 2023. The survey examined access to, and use of RPM, medical applications, and wearables, among respondents. Binary responses to the following questions were examined using logistic regression models: In the past 12 months, have you (i) used RPM, (ii) used a medical app, and (iii) used an electronic wearable device to monitor or track health or activity? A total of 305 surveys were returned, of which 212 were complete (69.5% completion rate). Demographically, 22% self-identified as Hispanic, 41% as non-Hispanic Black individuals, and 33% as non-Hispanic White individuals. Overall, 69% of respondents reported a pre-tax annual household income of less than $35 000 and 96﻿% indicated they own a smart phone. However, only 3 of 10 reported using RPM, 15% reported using a medical app, and 14% reported using wearables. Race was strongly associated with RPM usage, with Black respondents significantly less likely to have used RPM, compared to their white counterparts (OR: 0.31, P = .002). Education (bachelor’s degree or more OR: 4.79, P = .03) and higher income ($35 001 + OR: 4.68, P = .008) were strongly associated with medical app usage. In the wearables model, the same trend was observed with education (bachelor’s degree or more OR: 4.45, P = .04), and higher income ($35 001 + OR: 5.49, P = .01). Compared to earlier studies that have reported utilization rates of between 50% and 60%, our finding of much lower utilization in economically disadvantaged populations that are at greater risks for sub-optimal health outcomes gives cause for greater concern. Considering the ongoing proliferation of digital health technological modalities, this further highlights the need to explore and address equity-based barriers to these health tools.