bluuebunny/crossref_metadata_2025 huggingface dataset:
Responding to the Initial Challenge of the COVID-19 Pandemic: Analysis of International Responses and Impact in School and Higher Education
Authors: Stracke Christian M. , Burgos Daniel , Santos-Hermosa Gema , Bozkurt Aras , Sharma Ramesh Chander , Swiatek Cassafieres Cécile , dos Santos Andreia Inamorato , Mason Jon , Ossiannilsson Ebba , Shon Jin Gon , Wan Marian , Obiageli Agbu Jane-Frances , Farrow Robert , Karakaya Özlem , Nerantzi Chrissi , Ramírez-Montoya María Soledad , Conole Grainne , Cox Glenda , Truong Vi
Published: February 2022

This paper presents and analyses solutions where open education and open science were utilised to reduce the impact of the COVID-19 pandemic on education. The COVID-19 outbreak and associated lockdowns created huge challenges in school and higher education, demanding sudden responses which aimed to sustain pedagogical quality. Responses have varied from conservative to radically innovative. Universally, the COVID-19 pandemic disrupted and shocked societies worldwide, and education systems were on the front line. The lockdowns largely stopped face-to-face and formal education in almost all countries, and in most cases, distance learning soon became the ‘new normal’. A central challenge concerned sustaining educational visions and ideals in such circumstances. To better understand the state of the art in the educational landscape, we collected case studies from 13 countries during the first year of the pandemic starting on 11 March 2020 (when the World Health Organization declared a pandemic). This paper presents summaries of the full country reports that were collected and describe lessons learned. Our overall aim was to identify good practices and recommendations from the collected case studies that can be taken forward in the future. We categorised the responses on the three generic educational levels (macro, meso and micro) and identified seven key aspects and trends that are valid for all or most countries: (1) formal education at a distance for first time; (2) similar approaches for formal education; (3) missing infrastructure and sharing open educational resources; (4) diverse teaching and learning methods and practices; (5) open education and access to open educational resources; (6) urgent need for professional development and training for teachers and (7) assessing and monitoring learning environments, teachers and students. Finally, we identified key recommendations on how open education and open science can benefit formal education in schools and universities in the future, namely, improved awareness of open educational practices, provision of ICT infrastructure, embracing and sustaining the practice of open access publications and OERs, capacity building for stakeholders and finally encouraging research and development in the area of open education and open science. We found significant evidence for the proposition that open education and open science can support both traditional face-to-face and distance learning.
Sustainability in Higher Education during the COVID-19 Pandemic: A Systematic Review
Authors: Crawford Joseph , Cifuentes-Faura Javier
Published: February 2022

The COVID-19 pandemic has created cause for rapid innovation in, reimagining of, and pivoting of higher education institutions. Prior to 2020, the global higher education sector began to radically focus their efforts on creating sustainable institutions, and incorporated the United Nations’ Sustainable Development Goals (SDGs). The novel coronavirus pandemic may have changed that. This systematic review examines eight manuscripts, identified through a systematic search strategy on sustainability during the COVID-19 pandemic across 2020–2021. Interestingly, the low volume of manuscripts identified highlights potential learning and teaching risks, as priorities may have shifted during rapid digitalization and emergency remote teaching practices. These manuscripts focused on Goal 4, inclusive and equitable quality education (50%); Goal 8, decent work and economic growth; Goal 9, industry, innovation, and infrastructure (37.5%); and goal enabling through integrating and embedding sustainability into the curriculum (12.5%). The implications of this systematic review highlight a need to rebuild efforts to focus on the Sustainable Development Goals, particularly considering the evolving higher education landscape during COVID-19. While there were still considerable volumes of manuscripts on higher education and sustainability during 2020–2021, the lack of contextualization to current higher education conditions should be of concern for sustainability scholars. This systematic review creates a critical foundation for accelerating our understanding of achieving SDGs in higher education during and beyond the pandemic.
COVID-19 and City Space: Impact and Perspectives
Authors: Lekić Glavan Olivera , Nikolić Nenad , Folić Branislav , Vitošević Biljana , Mitrović Aleksandra , Kosanović Saja
Published: February 2022

The pandemic of the COVID-19 disease has radically changed human lifestyle and the usage of living space, especially in cities. With the prolongation of the crisis, the effects of COVID-19 on urban spaces are becoming more noticeable, but the definite changes that can inform approaches to future development, planning, and use of urban space have not yet been determined, as evidenced by the research carried out in this study. The research revealed that there exists the consensus in terms of several new guidelines whose application in design can simultaneously increase the resilience of urban environment to future pandemics and improve the overall quality of city life. These presented guidelines show that we may expect in the future a greater integration of nature-based solutions at various scales of the city, i.e., better ventilated, and naturally lit, more spacious, mixed-use, and flexible buildings surrounded by enlarged, multiplied, and multifunctional open spaces that safely receive the users who are carrying out those activities that were moved from the inner to the outer space.
Multi-Actor Social Networks: A Social Practice Approach to Understanding Food Hubs
Authors: Hyland John J. , Macken-Walsh Áine
Published: February 2022

Food hubs are collaborative entities that strategically manage the assemblage, delivery, and promotion of food from a range of local food producers. They are essentially multi-actor institutions, involving horizontal collaboration between producers and vertical collaborations up and down the food chain, involving all actors required to bring food products from producers to consumers. Although food hubs offer many advantages to both producers and consumers, they remain a recognisably neglected research topic in Europe. Furthermore, the strategic networks of actors involved in these collaborative entities is often overlooked. Empirically, this study draws from a collection of ‘good practices’ gathered for the Short Supply Chain Knowledge and Innovation Network (SKIN) EU-funded H2020 project. Drawing on a social practice approach and network diagrams, this article explores the good practices of three food hub typologies. This study primarily investigates the context in which food hubs practice multi-actor food provision. We apply social practice as a lens to ’zoom in’ and explore the shared materials, meanings and skills that aid such systems of provision. Social network diagrams are utilised to ‘zoom out’ to examine and facilitate the detection of key actors involved in food hubs’ strategic networks. This research addresses the lack of academic attention on European food hubs by placing practice as the central unit of focus. Our approach enables better comprehension of what constitutes a short food supply chain (SFSC) when orchestrated within three main typologies of food hubs. The findings are of interest to researchers, policy makers, agricultural development intermediaries, and actors involved in systems of food provision who are interested in understanding and supporting the functioning of SFSCs.
Association Analysis between Mechanical Symmetry and Requirements
Authors: Chen Xiuming , Qiu Qingying , Feng Peien
Published: February 2022

This paper focuses on obtaining the association rules between the symmetry of different mechanical structure layers and requirements through data mining, then suggests the selection of symmetry schemes under different requirement conditions, based on the mined association rules and their strength. Firstly, a thousand symmetry structure cases, namely text data, are transformed into binary data. Then, the data analysis software RapidMiner is used to build an association rule mining model to obtain the association rules from symmetry to symmetry, from symmetry to requirements, from requirements to requirements and from requirements to symmetry. Among them, this paper focuses on the association rules with requirements as the premise and symmetry as the conclusion. Finally, according to the support and confidence of the association rules, the selection of symmetry under a single requirement, multiple requirements and decomposable requirements is discussed and summarized.
Ultra-Long-Term Therapy of Benign Essential Blepharospasm with Botulinumtoxin A—30 Years of Experience in a Tertiary Care Center
Authors: Wabbels Bettina , Fimmers Rolf , Roggenkämper Peter
Published: February 2022

Aim of this study was to investigate the long-term results of botulinum toxin A (BoNT-A) injections for the treatment of benign essential blepharospasm (BEB) and to report our experience with (ultra-)long-term treatment with onabotulinumtoxin-A. We conducted a retrospective cross-sectional analysis at a university hospital. Patients with BEB and BoNT-A treatment were assigned to the Total Blepharospasm Group, patients with ≥21 onabotulinumtoxin-A injections to the Ona Long-Term Group. The Total Blepharospasm Group (n = 1940) included 33,933 BoNT-A injections. The age of patients at symptom onset was (mean ± SD) 58.0 ± 13.1 years, and 70.4% were female. The Ona long-term group (n = 234) included 10,632 onabotulinumtoxin-A injections. In this group, patients received 45.4 ± 22.9 injections with a mean dose of 22.2 IU ± 0.5. The duration of treatment was 12.6 ± 5.4 years, ranging from 2.9 to 30.0 years. The effect–duration–dose quotient did not change during long-term treatment. The observed side effects were comparable in type and frequency to other studies, even with the (ultra-)long treatment with onabotulinumtoxin-A. Our results, based on one of the largest patient populations and a treatment duration of up to 30 years, impressively demonstrate that onabotulinumtoxin-A is a safe and effective therapy for essential blepharospasm, even in the ultra-long term.
Characterization of Near Full-Length Transmitted/Founder HIV-1 Subtype D and A/D Recombinant Genomes in a Heterosexual Ugandan Population (2006–2011)
Authors: Balinda Sheila N. , Kapaata Anne , Xu Rui , Salazar Maria G. , Mezzell Allison T. , Qin Qianhong , Herard Kimberly , Dilernia Dario , Kamali Anatoli , Ruzagira Eugene , Kibengo Freddie M. , Song Heeyah , Ochsenbauer Christina , Salazar-Gonzalez Jesus F. , Gilmour Jill , Hunter Eric , Yue Ling , Kaleebu Pontiano
Published: February 2022

Detailed characterization of transmitted HIV-1 variants in Uganda is fundamentally important to inform vaccine design, yet studies on the transmitted full-length strains of subtype D viruses are limited. Here, we amplified single genomes and characterized viruses, some of which were previously classified as subtype D by sub-genomic pol sequencing that were transmitted in Uganda between December 2006 to June 2011. Analysis of 5′ and 3′ half genome sequences showed 73% (19/26) of infections involved single virus transmissions, whereas 27% (7/26) of infections involved multiple variant transmissions based on predictions of a model of random virus evolution. Subtype analysis of inferred transmitted/founder viruses showed a high transmission rate of inter-subtype recombinants (69%, 20/29) involving mainly A1/D, while pure subtype D variants accounted for one-third of infections (31%, 9/29). Recombination patterns included a predominance of subtype D in the gag/pol region and a highly recombinogenic envelope gene. The signal peptide-C1 region and gp41 transmembrane domain (Tat2/Rev2 flanking region) were hotspots for A1/D recombination events. Analysis of a panel of 14 transmitted/founder molecular clones showed no difference in replication capacity between subtype D viruses (n = 3) and inter-subtype mosaic recombinants (n = 11). However, individuals infected with high replication capacity viruses had a faster CD4 T cell loss. The high transmission rate of unique inter-subtype recombinants is striking and emphasizes the extraordinary challenge for vaccine design and, in particular, for the highly variable and recombinogenic envelope gene, which is targeted by rational designs aimed to elicit broadly neutralizing antibodies.
In Vitro Inhibition of Replication of Dengue Virus Serotypes 1–4 by siRNAs Bound to Non-Toxic Liposomes
Authors: Rodriguez-Salazar Carlos Andrés , Recalde-Reyes Delia Piedad , Bedoya Juan Pablo , Padilla-Sanabria Leonardo , Castaño-Osorio Jhon Carlos , Giraldo Maria Isabel
Published: February 2022

Dengue virus is a ssRNA+ flavivirus, which produces the dengue disease in humans. Currently, no specific treatment exists. siRNAs regulate gene expression and have been used systematically to silence viral genomes; however, they require controlled release. Liposomes show favorable results encapsulating siRNA for gene silencing. The objective herein was to design and evaluate in vitro siRNAs bound to liposomes that inhibit DENV replication. siRNAs were designed against DENV1–4 from conserved regions using siDirect2.0 and Web-BLOCK-iT™ RNAiDesigner; the initial in vitro evaluation was carried out through transfection into HepG2 cells. siRNA with silencing capacity was encapsulated in liposomes composed of D-Lin-MC3-DMA, DSPC, Chol. Cytotoxicity, hemolysis, pro-inflammatory cytokine release and antiviral activity were evaluated using plaque assay and RT-qPCR. A working concentration of siRNA was established at 40 nM. siRNA1, siRNA2, siRNA3.1, and siRNA4 were encapsulated in liposomes, and their siRNA delivery through liposomes led to a statistically significant decrease in viral titers, yielded no cytotoxicity or hemolysis and did not stimulate release of pro-inflammatory cytokines. Finally, liposomes were designed with siRNA against DENV, which proved to be safe in vitro.
Immunodominant Linear B-Cell Epitopes of SARS-CoV-2 Spike, Identified by Sera from K18-hACE2 Mice Infected with the WT or Variant Viruses
Authors: Levy Yinon , Alcalay Ron , Zvi Anat , Makdasi Efi , Peretz Eldar , Noy-Porat Tal , Chitlaru Theodor , Mandelboim Michal , Mazor Ohad , Rosenfeld Ronit
Published: February 2022

SARS-CoV-2 surface spike protein mediates the viral entry into the host cell and represents the primary immunological target of COVID-19 vaccines as well as post-exposure immunotherapy. Establishment of the highly immunogenic B-cell epitope profile of SARS-CoV-2 proteins in general, and that of the spike protein in particular, may contribute to the development of sensitive diagnostic tools and identification of vaccine` candidate targets. In the current study, the anti-viral antibody response in transgenic K18-hACE-2 mice was examined by implementing an immunodominant epitope mapping approach of the SARS-CoV-2 spike. Serum samples for probing an epitope array covering the entire spike protein were collected from mice following infection with the original SARS-CoV-2 strain as well as the B.1.1.7 Alpha and B.1.351 Beta genetic variants of concern. The analysis resulted in distinction of six linear epitopes common to the humoral response against all virus variants inspected at a frequency of more than 20% of the serum samples. Finally, the universality of the response was probed by cross-protective in vitro experiments using plaque-reducing neutralization tests. The data presented here has important implications for prediction of the efficacy of immune countermeasures against emerging SARS-CoV-2 variants.
Assessment of Seasonal Drought Impact on Potato in the Northern Single Cropping Area of China
Authors: Riao Dao , Liu Xingpeng , Guga Suri , Xu Jie , Li Kaiwei , Zhang Mingxi , Zhang Jiquan
Published: February 2022

Drought is one of the key limiting factors for potato yield in the northern single cropping area (NSCA) in China. To analyze the impact of drought on potato yield in the NSCA, this study first analyzed the variation of dry/wet conditions in the plantable areas on a seasonal scale using the standardized precipitation evapotranspiration index (SPEI). Secondly, the changes in yield structure in the last 36 years were systematically analyzed and divided the total yield change into planting area contribution and climate yield contribution. Finally, a regression model of the seasonal drought index and contributing factors of total yield change in different administrative regions was constructed. The results showed that the main factors affecting the total potato yield of the NSCA began to change from yield to planting area in the 1990s, while the barycenter of the output structure and population moved to the southwest, with grassland being the main source; dry/wet conditions (year i) had varying degrees of effect on contributing factors (year i, year i + 1) of total yield change in different administrative regions that were not limited to the growing season; the non-overlap of high-yield area, high-adaptability area and planting area was the urgent problem to be solved for the NSCA. The results of this study can provide a scientific basis for NSCA crop management and communication with farmers, providing new ideas for sustainable production in other agricultural regions in the world.
Rethinking Rural Development at the Village Level “The Villages of the Future” in France (Bourgogne Franche-Comté Region)
Authors: Berriet-Solliec Marielle , Lapostolle Dany , Lépicier Denis , Mangin Gaëtan , El Mostain Abdelhak
Published: February 2022

This article relates a transdisciplinary (participatory and interdisciplinary) research experiment conducted in the Territorial Living Lab for Ecological Transition (Burgundy Franche-Comté Region) that has led to constituting transdisciplinary epistemic communities. This research focuses on nine villages in this French region that have been selected to experiment with new designs for sustainable territorial development. It is part of an experimental scheme called “Villages of the Future” led by the Regional Council. These villages are less-than-2000-inhabitant municipalities, located in rural areas that are not under urban influence. The starting point is that development models based mainly on consumerism and the accumulation of wealth have shown their limits in a context of social and ecological transition. The implementation of these disciplinary epistemic communities leads to three main results: the passage from the villages’ storytelling to concrete projects, the enlargement of the local sphere of action and finally the impacts in terms of training this community’s stakeholders.
Experience of care for cancer patients after transferred radical cystectomy
Authors:   SBHI Samara Regional Clinical Oncological Dispensary, Pyatikop Veronika Mikhailovna
Published: February 2022

The article presents the experience of caring for cancer patients after a radical cystectomy. The necessity and importance of introducing an algorithm for caring for urological oncological patients is emphasized.
Особистісна філософія
Authors: Гранчаров Ангел
Published: February 2022

Автор статті розмірковує про сучасні проблеми трансфомації освіти, призначення філософії, духовності та свободи.
Як проявляється свідомість. Здатність людини до побудови гіпотези
Authors: Сабадаш Катерина
Published: February 2022

У дослідженні розглядається природа свідомості з огляду на її прояви на трьох рівнях пізнання. Аналізується епістемологічний досвід досліджень мислення Платона і І. Канта. Через ієрархію пізнаваних сутностей, описану Платоном, визначається відмінність рівнів пізнання. Каузальність фізичного світу як пізнавана структура емпіричної складової реальності не тільки піддається вивченню, але й виявляється підвладною внесенню змін з боку людини. Розгляд причинно-наслідкової структури завдяки раціональному рівню пізнання надає можливість визначити існуючий зв'язок через здатність вийти за межі каузальності. Основним питанням виступає можливість народження гіпотези як особистісної здатності свідомої істоти. Інтеллігибельне пізнання, що надає можливість інтуїтивного передпокладання, властиво тільки свідомості у її прояві (людині). Антиномії, описані І. Кантом, не є знанням, вони об'єднують їх (знання) в єдине розуміння. Гіпотеза є можливою тільки завдяки свідомості, яка здатна, втілюючись, надавати людині розуміння єдиного першопринципу і пізнання емпіричної каузальності.
Філософські аспекти здоров'я
Authors: Орбан Емануель
Published: February 2022

Здоровий спосіб життя – це виклик постмодерного суспільства, коріння якого сягає глибокої давнини, коли ми вже фіксуємо існування спа-терапевтичної терапії, пов’язаної з людським тілом. В даний час важливість здоров'я безпосередньо пов'язана з психологічними функціями, які, до речі, заявили грецькі філософи, роблячи безпосередній акцент на позитивному мисленні та чистому розумі. Основою успіху є рання профілактика небажаних захворювань, до якої, певною мірою, стосуються також правильні харчові, фізичні вправи та гігієнічні звички. Здоров’я є важливою цінністю, яка впливає на якість життя людини
Sentiment Polarity Identification of Social Media content using Artificial Neural Networks
Authors: Rajan K. Victor , Jackson Brittney
Published: February 2022

Sentiment of people about consumer goods and government policies for decision making is normally collected through feedback forms, surveys etc. The social network sites and micro blogging sites are considered a very good source of information nowadays because people share and discuss their opinions about a certain topic freely. With the increased use of technology and social media, people proactively express their opinion through social media sites like Twitter, Facebook, Instagram etc. A social media sentiment analysis can help companies to understand how people feel about their products. On the other hand, extracting the sentiment from social media text is a challenging task due to the complexity of natural language processing of social media language. Often these messages reflect the emotion, opinion and sentiment of the public through a mix of text, image, emoticons etc. These statements are often called electronic Word of Mouth (eWOM) and are much prevalent in business and service industry to enable customers to share their point of view.
Neural Network Design using a Virtual Reality Platform
Authors: Bibbò Luigi , Morabito Francesco Carlo
Published: February 2022

The evolution of Deep Learning (DL), a subset of machine learning, has made their use very effective in many artificial intelligence(AI) fields. In parallel Virtual Reality is going wide in many applications thanks to the proliferation of cameras in mobile devices and improved processing efficiency. Data visualization in deep learning is a fundamental element for which it can benefit from the advantages offered by the visualization of the VR for the development of the models. In addition, the researchers can widely use the editing of images and videos in the machine learning process to design a convolutional network suitable for image recognition. In this study, we want to demonstrate the usefulness of this approach in collecting data within virtual reality to train and optimize a convolutional neural network used to recognize human activities (HAR).
Method of Medical Prevention of Massive Blood Loss During Delivery of Women with Abnormally Invasive Placenta
Authors: Курлович И.В. , Гошкевич Е.А. , Ващилина Т.П. , Сушкова О.С.
Published: February 2022

В статье описан метод медицинской профилактики массивной кровопотери при родоразрешении женщин с приращением плаценты. Сформулированы основные положения и рекомендации по ведению и родоразрешению беременных с указанным осложнением. Представлен междисциплинарный подход к оказанию медицинской помощи. Определены срок и условия родоразрешения, необходимость дородовой госпитализации, профилактика и лечение анемии во время беременности, предоперационная подготовка, тип разреза на коже, место рассечения матки, применение рентгенэндоваскулярных и хирургических кровосберегающих технологий, условия выполнения реконструктивно-пластической органосохраняющей операции или гистерэктомии, интраоперационные и послеоперационные осложнения.

The article describes a method of medical prevention of massive blood loss during delivery of women with abnormally invasive placenta. The main provisions and recommendations for the management and delivery of pregnant women with this complication are formulated. An interdisciplinary approach to the provision of medical care is presented. The terms and conditions of delivery, the need for prenatal hospitalization, the prevention and treatment of anemia during pregnancy, preoperative preparation, the type of incision on the skin, the site of uterine dissection, the use of X-ray endovascular and surgical blood-saving technologies, the conditions for performing reconstructive-plastic organ-preserving surgery or hysterectomy, intraoperative and postoperative complications.
Retest Reliability and Ecological Validity of the Scale of Attitudes in the Field of Healthcare
Authors: Карпинский К.В. , Бойко С.Л.
Published: February 2022

Представлены результаты валидизации опросника «Шкала аттитюдов в области здравоохранения», предназначенного для измерения оценочных отношений испытуемого к различным субъектам, объектам и явлениям в сфере здравоохранения, на материалах белорусских популяционных выборок суммарной численностью 835 человек, в том числе в период распространения инфекции COVID-19. Опросник позволяет диагностировать индивидуальную выраженность антилекарственного, рентного, стоического, антиэлитарного, антибюрократического, деонтологического аттитюда, а также аттитюда возрастной дискриминации и фаворитизма в отношении врача. В ходе психометрической проверки опросника подтверждены его экологическая валидность, консистентная и ретестовая надежность. Представленная методика может использоваться в психодиагностических обследованиях и научных (психологических и медико-социологических) исследованиях, объектом которых выступает человек как субъект отношений с работниками и организациями здравоохранения по поводу здоровья, болезни и медицинской помощи.

There are presented the results of validation of the questionnaire “Scale of attitudes in healthcare” developed to measure the evaluation of the relationship of the subject to different subjects, objects, and phenomena in the field of health, based on the materials of the Belarusian population samples of total number of 835 people, including in the period of the infection COVID-19. The questionnaire lets to diagnose the individual severity of anti-drug, rent, stoic, anti-elitist, anti- bureaucratic, deontological attitudes, as well as the attitudes of age discrimination and favoritism towards the doctor. During the psychometric verification of the questionnaire, its environmental validity, consistency and retest reliability were confirmed. The presented method can be used in psychodiagnostic examinations and scientific (psychological and medical-sociological) studies, theobject of which is a person as a subject of relations with health care professionals and organizations on the issues of health, illness and medical care.
Biological Markers Affecting the Efficacy and Safety of Pharmacotherapy in Schizophrenia. Review
Authors: Голубева Т.С. , Докукина Т.В. , Объедков В.Г. , Гилеп А.А. , Гайдукевич И.В. , Башко Н.П. , Бокуть О.С. , Мороз А.В.
Published: February 2022

В обзоре литературы приведены данные о биологических маркерах, влияющих на эффективность и безопасность применения психотропных лекарственных средств при шизофрении. Оценка совокупности данных о наличии в генотипе пациента полиморфизмов генов изоферментов системы цитохрома Р450, транспортного белка Р-гликопротеина, молекул – мишеней психотропных лекарственных средств и функционально связанных с ними белков, а также данных о «метаболическом фенотипе» пациента может быть полезна при выборе тактики лечения.

The literature review provides data on biological markers that affect the efficacy and safety of psychotropic drugs in schizophrenia. Assessment of the data on the presence of polymorphisms of genes of isoenzymes of the cytochrome P450 system, P-glycoprotein transport protein, target molecules of psychotropic drugs, and proteins functionally associated with them in the patient’s genotype, as well as the data on the patient’s “metabolic phenotype” can be useful in choosing the tactics of treatment.
Life Span Prediction in Elderly Patients with Coronary Artery Disease Using Artificial Neural Network
Authors: Писарук А.В. , Асанов Э.О. , Войнаровская Г.П. , Шаповаленко И.С. , Дыба И.А.
Published: February 2022

Цель. Разработка метода прогнозирования продолжительности жизни пациентов пожилого возраста с ишемической болезнью сердца (ИБС) с помощью искусственной нейронной сети. Материалы и методы. Проведен ретроспективный анализ данных обследований 382 пациентов с ИБС в возрасте 60-80 лет, находившихся на стационарном лечении в ГУ «Институт геронтологии им. Д.Ф. Чеботарева НАМН Украины» в 1997-2014 гг. и умерших вследствие кардиоваскулярных причин. Анализировались данные об образе жизни, вредных привычках, сопутствующих заболеваниях, поле, а также возрасте пациентов на момент обследования. Для прогнозирования длительности жизни использована искусственная нейронная сеть MLP, обученная на массиве данных о пациентах. Результаты. По данным ANOVA, на продолжительность жизни достоверно влияют такие факторы, как пол, возраст на момент обследования, курение, характер труда, флуктуации артериального давления, наличие гипертонической болезни. Стандартная ошибка прогнозирования продолжительности жизни с помощью искусственной нейронной сети составила 4,38 года, а средняя абсолютная ошибка - 3,3 года. Выводы. Использование нейронной сети позволяет с высокой точностью прогнозировать продолжительность жизни пациентов с ИБС пожилого возраста. Наиболее информативными показателями для прогнозирования продолжительности жизни у пациентов с ИБС пожилого возраста с помощью нейронной сети являются курение, характер труда и пол.

Purpose. Development of a method of life span prediction in elderly patients with coronary artery disease (CAD) using an artificial neural network. Materials and methods. A retrospective analysis of data from examinations of 382 patients with CAD of 60-80 years old hospitalized at the State Institution “Institute of Gerontology named after D.F. Chebotaryov of the National Academy of Medical Sciences of Ukraine” in 1997-2014, who died due to cardiovascular causes, was conducted. The data on lifestyle, pernicious habits and comorbidities of the patients were analyzed. To predict the life span an artificial neural network MLP taught on the data of patients was used. Results. The ANOVA data showed that the life span is significantly affected by such factors as gender, age at examination, smoking, nature of work, blood pressure fluctuations, and hypertension presence. The standard error in life span prediction using an artificial neural network was 4.38 years, and the mean absolute error was 3.3 years. Conclusions. The neural network lets to predict the life span of patients with CAD with high accuracy. The most informative indicators for life span prediction in patients with CAD by neural network are smoking, nature of work, and gender.
Expression of Tissue Inhibitor of Matrix Metalloproteinases-2 in Healthy Oral Mucosa
Authors: Казеко Л.А. , Захарова В.А. , Субботко И.Л. , Бенеш Ю.Д.
Published: February 2022

Цель. Оценить характер экспрессии тканевого ингибитора матриксных металлопротеиназ-2 (ТИМП-2) в биоптатах здоровой слизистой оболочки полости рта.Материалы и методы. Забор биопсийного материала был выполнен у 30 пациентов. Биоптаты здоровой слизистой оболочки были получены во время дентальной имплантации.Результаты. Эпителиальная и стромальная экспрессия ТИМП-2 наблюдалась во всех проанализированных случаях. Умеренная экспрессия преобладала в эпителии, низкая экспрессия – в строме.Заключение. Здоровая слизистая оболочка полости рта характеризуется низкой и умеренной экспрессией ТИМП-2.

Purpose. To evaluate features of the expression of tissue inhibitor of matrix metalloproteinases-2 (TIMP-2) in biopsies of healthy oral mucosa.Methods. Sampling of biopsy material was performed in 30 patients. Biopsies of healthy oral mucosa were obtained during the dental implantation procedure.Results. Epithelial and stromal expression of TIMP-2 was observed in all analyzed cases. Moderate expression prevailed in the epithelium, low expression in the stroma.Conclusion. Healthy oral mucosa is characterized by low and moderate expression of TIMP-2.
Features of Mechanical Treatment of Root Canals with Rotating Tool Systems S-Profile
Authors: Данилова Д.В. , Зиновенко О.Г. , Новак Н.В. , Федоринчик О.В. , Цикра Н.В.
Published: February 2022

Обзорная статья посвящена проблеме выбора оптимальных вращающихся инструментов для механической обработки корневых каналов. В статье описаны представители файлов с s-образным поперечным сечением. Такой дизайн рабочей части обеспечивает инструментам хорошую режущую эффективность, уменьшенную силу трения, способность выводить дентинные опилки в апикальном направлении. Однако системы файлов с s-образным поперечным сечением, выпущенные разными производителями, существенно отличаются друг от друга. Для более ранних версий вращающихся инструментов s-стиля характерны линейки, состоящие из 4–5 инструментов, что обуславливает многоступенчатый подход к обработке корневых каналов. Современные вращающиеся инструменты, базовые комплекты которых состоят в среднем из 3 файлов, позволяют производить манипуляции 2–3 инструментами. Кроме того, улучшенные механические свойства благодаря специальной термической обработке никельтитанового сплава позволяют применять данные файлы многократно, а также в каналах со сложной анатомией. Преобладающая 04-конусность данных инструментов соответствует принципам рационального препарирования корневого канала и биологической целесообразности.

The review article is devoted to the problem of choosing the optimal rotating instruments for mechanical processing of root canals. The article describes representatives of files with an s-shaped cross-section. This design of the working part provides the instruments with good cutting efficiency, reduced friction force, and the ability to remove dentin chips in the apical direction. However, s-shaped file systems from different manufacturers differ significantly from each other. Earlier versions of the s-style rotary instruments feature a ruler of 4 to 5 instruments, resulting in a multi- step approach to root canal treatment. Modern rotating instruments, the basic sets of which consist, on average, of 3 files, allow manipulation of 2–3 instruments. In addition, the improved mechanicalproperties, due to the special heat treatment of the nickel-titanium alloy, make it possible to use these files multiple times, as well as in canals with complex anatomy. The predominant 04 taper of these instruments corresponds to the principles of rational root canal preparation and biological expediency.
Diagnosis and Treatment of Ulcerative Colitis in Children
Authors: Назаренко О.Н. , Кастюкевич Л.И. , Горная Н.Н. , Василец Ю.Н. , Сокол Ю.А.
Published: February 2022

Воспалительные заболевания кишечника (ВЗК) в настоящее время являются частой причиной гемоколитов у детей в возрасте от 1 года до 17 лет. В последние 10-15 лет имеет место существенное нарастание частоты встречаемости данной патологии. С учетом тяжести течения ВЗК и высокой вероятности неблагоприятного прогноза, знание основ диагностики и лечения данной патологии, а также периодическое изучение ее региональных особенностей является актуальным. В соответствии с «Porto критериями» диагностики воспалительных заболеваний кишечника у детей и подростков последнего (2014 г.) пересмотра, разработанными педиатрической рабочей группой по воспалительным заболеваниям кишечника Европейской ассоциации детских гастроэнтерологов, гепатологов и нутрициологов (ESPGHAN), выделены 5 классов педиатрических воспалительных заболеваний кишечника, или «PIBD-Classes»: типичный язвенный колит (ЯК), атипичный ЯК, неклассифицированный колит, Крон-колит и болезнь Крона. Подробно в данной публикации будет описан типичный язвенный колит.

Inflammatory bowel disease (IBD) is now a common cause of hemocolitis in children aged 1 to 17 years. In the last 10-15 years, there has been a significant increase of the incidence of this pathology. Taking into account the severity of the course of IBD and high probability of unfavorable prognosis, knowledge of the basics of diagnosis and treatment of this pathology, as well as the periodic study of their regional characteristics is relevant. In accordance with the "Porto Criteria" for the diagnosis of inflammatory bowel diseases in children and adolescents of the last (2014) revision, developed by the pediatric working group on inflammatory bowel diseases of the European Association of Pediatric Gastroenterologists, Hepatologists and Nutritionists (ESPGHAN), 5 classes of pediatric inflammatory bowel disease, or "PIBD-Classes" were distinguished: typical ulcerative colitis (UC), atypical UC, unclassified colitis, Crohn colitis and Crohn’s disease. Typical ulcerative colitis will be described in detail in this publication.
Evrişimsel Sinir Ağı Temelli Yüz Tanıma Yöntemleri ile Robot Resim Oluşturma Uygulaması
Authors: AYATA Faruk , ÇAVUŞ Hayati
Published: February 2022

Create a Sketch Application with Convolutional Neural Network Based Face Recognition Methods
Stockwell Dönüşümü, ONE-R Özellik Seçme Yöntemi ve Rastgele Orman Algoritması ile Güç Kalitesi Bozulumu Sinyallerinin Sınıflandırılması
Authors: AKMAZ Düzgün
Published: February 2022

Bu çalışmada Güç Kalitesi (GK) bozulumu sinyallerinin sınıflandırılması için bir yöntem uygulanmıştır. Yöntemde Stockwell dönüşümü (S-dönüşümü-SD) farklı GK sinyallerine uygulanması ile 2 boyutlu Zaman-Frekans (TF Time-Frequency) matrisi elde edilmiştir. Daha sonra elde edilen matrisin ve GK sinyallerinin farklı entropi değerleri ile sınıflandırma öznitelikleri elde edilmiştir. Ancak elde edilen sınıflandırma özniteliklerinin hepsinin kullanılması gerçekleştiren yöntemin karmaşık hale gelmesine neden olmaktadır. Bu yüzden bu çalışmada ONE-R özellik seçme yöntemi sınıflandırmadaki etkili özelliklerin belirlenmesi, daha az öznitelik ve daha basit bir yapı ile yüksek sınıflandırma başarısının sağlanması için kullanılmıştır. Belirlenen öznitelikler ve Rastgele Orman (RO) algoritması ile GK bozulumları sınıflandırılmıştır. Benzetim sonuçları yöntemin başarılı olduğunu göstermiştir. Aynı zamanda benzetim sonuçları gerçekleştirilen yöntemin bir kere eğitildikten sonra, 35dB ve yukarısındaki gürültü seviyelerine sahip farklı GK bozulumlarının sınıflandırması içinde etkili olduğunu göstermiştir.
Bağdere Tufası’nın Jeolojik, Jeokimyasal ve Jeokronolojik Özellikleri (Elazığ, D Türkiye)
Authors: ÇOLAK EROL Serap , AKSOY Ercan , ÖZKUL Mehmet
Published: February 2022

Çalışmaya konu olan tufa yüzleği, Türkiye’nin ikinci büyüklükteki neotektonik yapısı olan sol yanal doğrultu atımlı Doğu Anadolu Fay Sistemi’nin önemli zonlarından biri olan Elazığ Fay Zonu üstünde, Elazığ şehir merkezinin yaklaşık 20 km güneybatısında bulunur.

Tufaların yanal-düşey ilişkili olduğu Kuvaterner yaşlı Palu Formasyonu, karasal kökenli kırıntılı çökellerle karakterize edilir. Tufa oluşumunda kaynak kaya rolü oynayan Devoniyen-Jura yaşlı Keban Metamorfitleri’nin Elazığ çevresindeki yüzlekleri, çoğunlukla mermerlerle karakterize edilir. Keban Metamorfitleri’nin litolojisi ve sol yanal doğrultu atımlı Elazığ Fay Zonu’nun meydana getirdiği kırıklı yapı, akışkan dolaşımında ve bundan dolayı tufanın oluşmasında önemli bir görev almıştır.

Tufa örneklerinde belirlenen element miktarları, Ca: 384719-390151 ppm, Mg: 3498-4764 ppm, Sr: 112-338 ppm düzeyindedir. δ13C değerleri, 0.4 ila 2.6 (‰ PDP), δ18O değerleri ise -9.9 ila -11.4 (‰PDB) arasındadır. Çalışmadan elde edilen veriler birlikte değerlendirildiğinde, Bağdere tufasının, sığ göl ortamında oluştuğu düşünülmektedir. Örneklerden elde edilen U-Th yaş verileri, tufa çökeliminin günümüzden en azından 524,597 yıl önce başlamış olduğuna işaret etmektedir.
Türkçe Tweetler için Derin Özellik Çıkarımı Tabanlı Yeni Bir Duygu Sınıflandırma Modeli
Authors: SALUR Mehmet Umut , AYDIN İlhan
Published: February 2022

Sosyal medya uygulamaların yaygın kullanımı, insanları her dakika yeni veri üretmelerine neden olmuştur. Ses ve resim veri türlerinin yanında metin tabanlı verilerin boyutu daha hızlı artmaktadır. Metin tabanlı veriler, anlamlı kelimeler haricinde birçok içerik barındırabilmektedir. Metin işleme çalışmaları için bu içerikler gürültü olarak isimlendirilir ve metin önişleme aşamasında bu içerikler veri kümelerinden çıkartılır. Özellikle Twitter veri kümeleri üzerinde yapılan duygu sınıflandırma çalışmalarında, veri kümeleri metin temsilleri oluşturulmadan önce yapılan önişlemler aşamasında URL, noktalama işareti ve emoji gibi içeriklerden arındırılmaktadır. Twitter sosyal medya uygulaması için gürültü olarak nitelendirilen içerikler aslında bir bakıma kullanıcının duygu ve düşüncelerinin bir parçası niteliğindedir. Bu çalışmada veri kümesinden temizlenen gürültü verilerinden de özellik çıkarımı yapılmış olup, tweet’ler içerisindeki duygu daha iyi ortaya çıkarılmıştır. Çalışmada önerilen yeni duygu sınıflandırma modeli, derin öğrenme yöntemleriyle çıkartılan derin özellikler ile veri önişlemleri aşamasında silinen içeriklerden elle çıkartılan özellikleri birlikte kullanımına dayanmaktadır. Önerilen model literatürde çalışılan Türkçe Twitter veri kümesi üzerinde gerçekleştirilmiştir. Önerilen modelin sınıflandırma performansının önceki çalışmalardan daha iyi olduğu yapılan deneylerle gösterilmiştir.
A Suggestion System According to Fabric Control Time
Authors: YAŞAR ÇIKLAÇANDIR Fatma , UTKU Semih
Published: February 2022

Automatic systems facilitate many areas of life. The combination of image processing and machine learning has opened the door to a new world. In spite of this, most of the control is done manually in the factories where fabrics, which are the main material of textile, are produced. The studies to automate this control process are still insufficient. In this study, it is aimed to develop a system with the highest performance in a short time. Different feature extraction methods (Principal Component Analysis, Local Binary Pattern) and different classifiers (K-Nearest Neighbor, Support Vector Machine) have been tested in terms of time and different performance metrics. Different systems have been suggested depending on whether the fabric control is done during or after production.
Sulfuro de carbono
Authors:   , Lambre Dante
Published: February 2022

El sulfuro de carbono, cuya fórmula es S2C, es un líquido incoloro, que se altera en presencia de la luz, hierve a 46º de temperatura y es volátil a la temperatura ambiente, su peso específico es de 1,27; a -116º se solidifica. Es poco soluble en el agua; soluble en alcohol, éter y bencina. Es solvente del yodo, fósforo, azufre, alcanfor, aceites, grasas, aceites esenciales, resinas, etc. El sulfuro de carbono es combustible y quema con una llama de color azul, transformándose en anhídrido sulfuroso y anhídrido carbónico. Tiene las propiedades de ser más inflamable que el éter, por lo cual es necesario usarlo con muchas precauciones.
Resultado del catastro tuberculínico abreugráfico realizado en el Departamento de Educación Fisica y Sanidad de la Universidad Nacional de La Plata
Authors:   , Maio Horacio Nicolás
Published: February 2022

El solo enunciado del presente trabajo justifica plenamente la importancia de este tema. Se vive en estos momentos, para la mejor suerte de la humanidad, una nueva era podríamos decir, hacia una orientación más científica, razonable y humana, cual es la medicina de la prevención. Los conocimientos médicos sucedidos desde Hipócrates y aún antes que él, han sido un encadenamiento ininterrumpido de hechos necesarios para la madurez de la ciencia biológica que anida entre otras muchas en la parte médlca, con los exámenes de salud. Este suceso aunque no igualado en nuestros antecesores correspondo por su vigencia al momento actual que vivimos. Llamaba siempre la atención la observaclón de individuos portadores de lesiones de etiología variada de localización diversa pero especialmente pulmonar en las cuales el interrogatorio más cuidadoso no permitía, frente a la ausencia de síntomas o a los frustos de los mismos, orientarse hacia el diagnóstico del mal.
To the question of connective tissue disorders in children and adolescents with orthopedic pathology
Authors: Guskova Oksana , Murga Vladimir , Ivanov Anatoly , Rasskazov Leonid , Shalatonov Nikita , Krestyashin Vladimir , Ivanov Yury , Marasanov Nikolay , Schelochenkova Tatjana , Berezovskiy Ivan
Published: February 2022

Clinical and histological changes were studied in 96 adolescents with knee pathology of non-traumatic genesis, with signs of connective tissue disease (CTD). The detection of connective tissue dysplasia was carried out according to the data of a clinical examination, functional and radiation diagnostic methods in accordance with the Russian recommendations for algorithms for the diagnosis and treatment of children with connective tissue disease (2015). Serial sections stained with hematoxylin and eosin were examined on an Olympus CX-41 microscope at a magnification of ×100, ×200, ×400. Some of the preparations were additionally stained with picrofuchsin according to van Gieson. Signs of a pronounced diffuse pathological process of a degenerative-dystrophic nature were revealed, caused by hypoxic and metabolic disorders, which led to the development of pain syndrome and became a reason for subsequent surgical intervention.
Clinical types of hard palatal vault in people with various gnathic dental arches within physiologically optimal norm
Authors: Kochkonyan Taisiya , Al-Harazi Ghamdan , Domenyuk Dmitry , Dmitrienko Sergei , Budaichieva Milana , Domenyuk Stanislav
Published: February 2022

The study is based on an analysis of conebeam computed tomograms and biometric examination of jaw cast models obtained from 68 people aged 21–35 with permanent teeth physiological occlusion. The findings were used to identify the relationship between the morphometric values (height, depth) of the palatal vault, and the linear parameters (length, width) of dental arches. In patients with mesognathic dental arches, the palatal vault index, taken as a ratio between the palate height to the alveolar part width, was 41.14 ± 2.87%, whereas the width indicators exceeded (by 2.43 times on average) the hard palate vault depth parameters. People with dolichognathic dental arches had the value of the palatal vault index reaching 51.75 ± 2.57%, while the width indicators exceeded the depth parameters of the hard palate vault by 1.93 times on average. In patients with brachygnathic dental arches, the palatal vault index was 28.29 ± 2.62%, with the width indicators exceeding the depth parameters by 3.53 times on average. There is evidence showing that mesognathic dental arches have mesopalatal (proportional) palatal vault matching them, while in case of dolichognathic dental arches, the match is dolichopalatal (high and narrow) type of vault. As for brachygnathic dental arches, then the match is brachypalatal, i.e. a low and wide vault. The obtained data can be used in clinical orthodontics, orthopedic dentistry, as well as maxillofacial surgery to assess the hard palate parameters, to diagnose palatal vault pathologies, and to select respective treatment approaches in view of the dental arches shape and size anomalies.