bluuebunny/crossref_metadata_2025 huggingface dataset:
Anti-Carceral Approaches to Addressing Harms Against Animals: Considerations on Multispecies Restorative and Transformative Justice
Authors: Struthers Montford Kelly , Chang Darren , Yalcin Selingul
Published: November 2024

The animal protection movement has developed an increasingly close working relationship with the criminal punishment system through lobbying and campaigning for harsher punishments for animal abuse, while at the same time showing an interest in restorative justice (RJ) as a response to harm against animals. In this article, we take a critical position aligned with anti-carceral feminists and prison abolitionists against the carceral systems that fail humans and animals in circumstances of violence. We consider the potential of RJ as an alternative approach to address and prevent harm against animals in abuse cases on an individual level while highlighting the limitations of RJ in achieving the necessary changes on a societal level to end structurally produced violence against animals, such as industrial animal exploitation. We propose that transformative justice (TJ), which involves some RJ processes, is the most promising approach that could achieve justice for both humans and nonhumans in the long term without reproducing traumas and violence for the individuals and communities involved in harm reduction and prevention. Drawing on examples of RJ and TJ as developed and practised in marginalized human communities, we apply their lessons to thinking through similar practices in the context of animal abuse and neglect.
International Entrepreneurial Spin-Offs: An Ambidextrous Approach to Internationalization
Authors: Cui Lin , Lew Yong Kyu , Khan Zaheer , Lu Jiangyong
Published: November 2024

This article investigates the internationalization process of incubating, parenting, and eventually spinning-off overseas entrepreneurial ventures originating from emerging markets. In a comparative case study of Chinese high-tech firms, we leveraged multiple sources of data to reveal (1) how the exploitation of parent firms’ technological and platform resources enables them to initiate, support, and eventually profit from the international growth of foreign ventures that autonomously engage in the exploration of product and market innovations, and (2) how ambidextrous synergy was created through the continuous exchange, combination, and reconfiguration of knowledge and resources between parent firms and foreign ventures. These findings extend our understanding of how Chinese high-tech firms manage the learning process in overseas venturing. We draw implications of these findings for research and practice.
Evil and the Demonic
Authors: Roy Louis
Published: November 2024

This essay highlights the centrality of ‘the demonic’ in human experience, both collective and personal. It argues in favour of the possibility of explaining it; it dismisses its personification into a demon or several demons; it then proceeds towards a definition and a phenomenology of it; it examines its effects; and it portrays a final feature, namely resentment and revenge, as well as a religious response.
Han-Centrism and Multiethnic Nation-Building in China and Taiwan: A Comparative Study since 1911
Authors: Leibold James , Chen Julie Yu-Wen
Published: November 2024

Although the People’s Republic of China (PRC) and the Republic of China (ROC, also known as Taiwan) and their ruling parties have altered over time, there are quite a few similarities between their models of nation-building, more than is commonly acknowledged. The guofu (father) of the modern Chinese state, Sun Yat-sen, one of the few political leaders who is still honored on both sides of the Taiwan Straits, claimed all the peoples and territories of the former Qing empire comprised a single national community, the so-called Zhonghua minzu. Yet a Han super-majority has long sat at the center of this national imaginary. In this article, we ask what has happened to Sun’s imagined community across the last century, and how it has evolved in the two competing Chinese states the PRC and the ROC. We seek to demonstrate the enduring challenge of Han-centrism for multiethnic nation-building in both countries, while illustrating how shifts in domestic and international politics are altering this national imaginary and the place of ethnocultural diversity within it.
CYT and SKT manifolds with parallel Bismut torsion
Authors: Brienza Beatrice , Fino Anna , Grantcharov Gueo
Published: November 2024

In the present article, we study compact complex manifolds admitting a Hermitian metric which is strong Kähler with torsion (SKT) and Calabi–Yau with torsion (CYT) and whose Bismut torsion is parallel. We first obtain a characterization of the universal cover of such manifolds as a product of a Kähler Ricci-flat manifold with a Bismut flat one. Then, using a mapping torus construction, we provide non-Bismut flat examples. The existence of generalized Kähler structures is also investigated.
Dilemmas of Powerlessness: The Ethical Dimensions of Political Action in the Swedish Parliament
Authors: Martinsson Joel
Published: November 2024

What are the most challenging ethical dilemmas for politicians, and how do they handle them? The classical literature on ethical dilemmas in politics has mainly explored them as conflicts between ethical principles in high-stakes decisions. However, empirical evidence of the extent to which such dilemmas accurately reflect the experience of most politicians is scarce. Drawing on extensive in-depth interviews with Swedish parliamentarians, I show that their dilemmas stem mainly from powerlessness. Powerlessness in politics manifests itself in primarily two ways: relational powerlessness, which is driven by constraints like party and constituency loyalties, and inherent powerlessness due to formal and informal barriers like constitutional mandates and limited time and resources. This study contributes to the field of political ethics by anchoring political dilemmas in everyday democratic politics and by introducing powerlessness as a new central concept. In doing so, it supplements our understanding of ethical dilemmas in politics with insights from those confronting them.
Silence and Listening
Authors: Heiti Warren
Published: November 2024

One kind of good listener aspires to be sensitive to the testimony of injustice. Under conditions of oppression, this testimony is silenced. One cause of the silencing is that a dominant rights-based model of distributive justice interferes with our appreciation of a needs-based model of radically egalitarian justice. Another cause is that ambient prejudices threaten to impair the listener. A good listener is not only an individual but also a social animal, one who needs to engage with others in a dialectic of attention in order to undo their own prejudices.
Introduction to a Symposium on The Limitations of the Open Mind
Authors: Ballantyne Nathan
Published: November 2024

I introduce the book symposium on Jeremy Fantl's The Limitations of the Open Mind. The symposium began as a session at the 2023 American Philosophical Association meeting in Montreal; it features replies to Fantl's book by Nathan Ballantyne and Miriam Schleifer McCormick with replies to the replies by Fantl.
Enquête, questions et actions
Authors: Guilielmo Benoit
Published: November 2024

Cet article vise à élucider la nature de l'enquête. Je présente tout d'abord les desiderata communs à toute théorie de l'enquête. Je catégorise ensuite l'enquête comme un processus structuré en me concentrant sur ses composantes essentielles : des attitudes de questionnement guidant des actions. Enfin, je me penche sur l'objection récente selon laquelle les attitudes de questionnement ne sont pas nécessaires à l'enquête. Je défends la thèse selon laquelle l'enquête est un processus structuré essentiellement constitué d'attitudes de questionnement ayant deux rôles fonctionnels précis, soit d'initier et de guider le déploiement de capacités cognitives en vue d'un but épistémique.
A novel shiga toxigenic E. coli sequence type harbouring multidrug resistance isolated from raw milk
Authors: Nampoothiri Anjali Karunatt , Kalyanikkutty Sudha
Published: November 2024

The objective was to examine the prevalence of extended-spectrum β-lactam (ESBL) resistance among Shiga toxigenic Escherichia coli (STEC) isolated from raw milk. The findings from disc diffusion analysis and polymerase chain reaction revealed a high occurrence of ESBL resistance, specifically to penicillins, cephalosporins, and carbapenems, in isolated STEC strains. Additionally, a distinct sequence type of STEC was also identified in milk through comparative analysis.
Exercise, nutrition and medicine timing in metabolic health: implications for management of type 2 diabetes
Authors: Peña Carrillo Brenda J. , Sivasengh Rashmi , Johnstone Alexandra M. , Gabriel Brendan M.
Published: November 2024

Chrono-medicine considers circadian biology in disease management, including combined lifestyle and medicine interventions. Exercise and nutritional interventions are well-known for their efficacy in managing type 2 diabetes, and metformin remains a widely used pharmacological agent. However, metformin may reduce exercise capacity and interfere with skeletal muscle adaptations, creating barriers to exercise adherence. Research into optimising the timing of exercise has shown promise, particularly for glycaemic management in people with type 2 diabetes. Aligning exercise timing with circadian rhythms and nutritional intake may maximise benefits. Nutritional timing also plays a crucial role in glycaemic control. Recent research suggests that not only what we eat but when we eat significantly impacts glycaemic control, with strategies like time-restricted feeding (TRF) showing promise in reducing caloric intake, improving glycaemic regulation and enhancing overall metabolic health. These findings suggest that meal timing could be an important adjunct to traditional dietary and exercise approaches in managing diabetes and related metabolic disorders. When taking a holistic view of Diabetes management and the diurnal environment, one must also consider the circadian biology of medicines. Metformin has a circadian profile in plasma, and our recent study suggests that morning exercise combined with pre-breakfast metformin intake reduces glycaemia more effectively than post-breakfast intake. In this review, we aim to explore the integration of circadian biology into type 2 diabetes management by examining the timing of exercise, nutrition and medication. In conclusion, chrono-medicine offers a promising, cost-effective strategy for managing type 2 diabetes. Integrating precision timing of exercise, nutrition and medication into treatment plans requires considering the entire diurnal environment, including lifestyle and occupational factors, to develop comprehensive, evidence-based healthcare strategies.
Circadian rhythms, feeding patterns and metabolic regulation: implications for critical care
Authors: Smith Harry A. , Betts James A.
Published: November 2024

Endogenous biological rhythms synchronise human physiology with daily cycles of light-dark, wake-sleep and feeding-fasting. Proper circadian alignment is crucial for physiological function, reflected in the rhythmic expression of molecular clock genes in various tissues, especially in skeletal muscle. Circadian disruption, such as misaligned feeding, dysregulates metabolism and increases the risk of metabolic disorders like type 2 diabetes. Such disturbances are common in critically ill patients, especially those who rely on enteral nutrition. Whilst continuous provision of enteral nutrition is currently the most common practice in critical care, this is largely dictated by convenience rather than evidence. Conversely, some findings indicate that intermittent provision of enteral nutrition aligned with daylight may better support physiological functions and improve clinical/metabolic outcomes. However, there is a critical need for studies of skeletal muscle responses to acutely divergent feeding patterns, in addition to complementary translational research to map tissue-level physiology to whole-body and clinical outcomes.
Regional neural functional efficiency across schizophrenia, bipolar disorder, and major depressive disorder: a transdiagnostic resting-state fMRI study
Authors: Yang Jun , Liu Zhening , Pan Yunzhi , Fan Zebin , Cheng Yixin , Wang Feiwen , Sun Fuping , Wu Guowei , Ouyang Xuan , Tao Haojuan , Yang Jie , Palaniyappan Lena
Published: November 2024

Background

Major psychiatric disorders (MPDs) are delineated by distinct clinical features. However, overlapping symptoms and transdiagnostic effectiveness of medications have challenged the traditional diagnostic categorisation. We investigate if there are shared and illness-specific disruptions in the regional functional efficiency (RFE) of the brain across these disorders.

Methods

We included 364 participants (118 schizophrenia [SCZ], 80 bipolar disorder [BD], 91 major depressive disorder [MDD], and 75 healthy controls [HCs]). Resting-state fMRI was used to caclulate the RFE based on the static amplitude of low-frequency fluctuation, regional homogeneity, and degree centrality and corresponding dynamic measures indicating variability over time. We used principal component analysis to obtain static and dynamic RFE values. We conducted functional and genetic annotation and enrichment analysis based on abnormal RFE profiles.

Results

SCZ showed higher static RFE in the cortico-striatal regions and excessive variability in the cortico-limbic regions. SCZ and MDD shared lower static RFE with higher dynamic RFE in sensorimotor regions than BD and HCs. We observed association between static RFE abnormalities with reward and sensorimotor functions and dynamic RFE abnormalities with sensorimotor functions. Differential spatial expression of genes related to glutamatergic synapse and calcium/cAMP signaling was more likely in the regions with aberrant RFE.

Conclusions

SCZ shares more regions with disrupted functional integrity, especially in sensorimotor regions, with MDD rather than BD. The neural patterns of these transdiagnostic changes appear to be potentially driven by gene expression variations relating to glutamatergic synapses and calcium/cAMP signaling. The aberrant sensorimotor, cortico-striatal, and cortico-limbic integrity may collectively underlie neurobiological mechanisms of MPDs.
The effect of vitamin D supplementation on depression: a systematic review and dose–response meta-analysis of randomized controlled trials
Authors: Ghaemi Shadi , Zeraattalab-Motlagh Sheida , Jayedi Ahmad , Shab-Bidar Sakineh
Published: November 2024

The impact of vitamin D supplementation on depressive symptoms remains uncertain. This study aimed to investigate the dose-dependent effects of vitamin D supplementation on depressive and anxiety symptoms in adults. We systematically searched PubMed, Scopus, and Web of Science up to December 2022 to identify randomized controlled trials evaluating the effects of vitamin D3 supplementation on depression and anxiety symptoms in adults. Using a random-effects model, we calculated the standardized mean difference (SMD) for each 1000 IU/day vitamin D3 supplementation. The GRADE tool assessed the certainty of evidence. Our analysis included 31 trials with 24189 participants. Each 1000 IU/day vitamin D3 supplementation slightly reduced depressive symptoms in individuals with and without depression (SMD: −0.32, 95% CI −0.43 to −0.22; GEADE = moderate). The effect was more pronounced in those with depressive symptoms (SMD: −0.57, 95% CI −0.69 to −0.44; n = 15). The greatest reduction occurred at 8000 IU/day (SMD: −2.04, 95% CI −3.77 to −0.31). Trials with follow-up ⩽8 weeks (SMD: −0.45, 95% CI −0.70 to −0.20; n = 8) and 8 to ⩽24 weeks (SMD: −0.47, 95% CI −0.70 to −0.24; n = 15) showed stronger effects compared to those lasting 24 to ⩽52 weeks (SMD: −0.13, 95% CI −0.28 to 0.02; n = 5) or longer than 52 weeks (SMD: 0.14, 95% CI −0.16 to 0.44; n = 3) (p group difference <0.001). Vitamin D3 supplementation had no significant effects on anxiety symptoms. In summary, this study suggests that vitamin D3 supplementation may effectively reduce depressive symptoms in short term. Further high-quality trials are warranted for a conclusive assessment of its impact on anxiety.
Association of cardiovascular-kidney-metabolic health and social connection with the risk of depression and anxiety
Authors: Huang Xinghe , Liang Jie , Zhang Junyu , Fu Jiayi , Xie Wuxiang , Zheng Fanfan
Published: November 2024

Background

To explore the association of cardiovascular-kidney-metabolic (CKM) health with the risk of depression and anxiety and to investigate the joint association of CKM health and social connection with depression and anxiety.

Methods

This prospective cohort study included 344 956 participants from the UK Biobank. CKM syndrome was identified as a medical condition with the presence of metabolic risk factors, cardiovascular disease, and chronic kidney disease, and was classified into five stages (stage 0–4) in this study. Loneliness and social isolation status were determined by self-reported questionnaires. Cox proportional hazards models were applied for analyses.

Results

Compared with participants in stage 0, the HRs for depression were 1.17 (95% CI 1.10–1.25), 1.40 (95% CI 1.33–1.48), and 2.14 (95% CI 1.98–2.31) for participants in stage 1, 2–3, and 4, respectively. Similarly, participants in stage 2–3 (HR = 1.20, 95% CI 1.14–1.26) and stage 4 (HR = 1.63, 95% CI 1.51–1.75) had greater risks of incident anxiety. We found additive interactions between loneliness and CKM health on the risk of depression and anxiety. Participants simultaneously reported being lonely and in stage 4 had the greatest risk of depression (HR = 4.44, 95% CI 3.89–5.07) and anxiety (HR = 2.58, 95% CI 2.21–3.01) compared with those without loneliness and in stage 0. We also observed an additive interaction between social isolation and CKM health on the risk of depression.

Conclusions

Our findings suggest the importance of comprehensive interventions to improve CKM health and social connection to reduce the disease burden of depression and anxiety.
Using machine learning to determine a functional classifier of reward responsiveness and its association with adolescent psychiatric symptomatology
Authors: Blair Robert James Richard , Bashford-Largo Johannah , Dominguez Ahria , Dobbertin Matthew , Blair Karina S. , Bajaj Sahil
Published: November 2024

Background

Machine learning (ML) has developed classifiers differentiating patient groups despite concerns regarding diagnostic reliability. An alternative strategy, used here, is to develop a functional classifier (hyperplane) (e.g. distinguishing the neural responses to received reward v. received punishment in typically developing (TD) adolescents) and then determine the functional integrity of the response (reward response distance from the hyperplane) in adolescents with externalizing and internalizing conditions and its associations with symptom clusters.

Methods

Two hundred and ninety nine adolescents (mean age = 15.07 ± 2.30 years, 117 females) were divided into three groups: a training sample of TD adolescents where the Support Vector Machine (SVM) algorithm was applied (N = 65; 32 females), and two test groups– an independent sample of TD adolescents (N = 39; 14 females) and adolescents with a psychiatric diagnosis (major depressive disorder (MDD), generalized anxiety disorder (GAD), attention deficit hyperactivity disorder (ADHD) & conduct disorder (CD); N = 195, 71 females).

Results

SVM ML analysis identified a hyperplane with accuracy = 80.77%, sensitivity = 78.38% and specificity = 88.99% that implicated feature neural regions associated with reward v. punishment (e.g. nucleus accumbens v. anterior insula cortices). Adolescents with externalizing diagnoses were significantly less likely to show a normative and significantly more likely to show a deficient reward response than the TD samples. Deficient reward response was associated with elevated CD, MDD, and ADHD symptoms.

Conclusions

Distinguishing the response to reward relative to punishment in TD adolescents via ML indicated notable disruptions in this response in patients with CD and ADHD and associations between reward responsiveness and CD, MDD, and ADHD symptom severity.
Exploring associations between ADHD symptoms and emotional problems from childhood to adulthood: shared aetiology or possible causal relationship?
Authors: You Yuan , Oginni Olakunle A. , Rijsdijk Fruhling V. , Lim Kai X. , Zavos Helena M. S. , McAdams Tom A.
Published: November 2024

Background

ADHD symptoms are associated with emotional problems such as depressive and anxiety symptoms from early childhood to adulthood, with the association increasing with age. A shared aetiology and/or a causal relationship could explain their correlation. In the current study, we explore these explanations for the association between ADHD symptoms and emotional problems from childhood to adulthood.

Methods

Data were drawn from the Twins Early Development Study (TEDS), including 3675 identical and 7063 non-identical twin pairs. ADHD symptoms and emotional symptoms were reported by parents from childhood to adulthood. Self-report scales were included from early adolescence. Five direction of causation (DoC) twin models were fitted to distinguish whether associations were better explained by shared aetiology and/or causal relationships in early childhood, mid-childhood, early adolescence, late adolescence, and early adulthood. Follow-up analyses explored associations for the two subdomains of ADHD symptoms, hyperactivity-impulsivity and inattention, separately.

Results

The association between ADHD symptoms and emotional problems increased in magnitude from early childhood to adulthood. In the best-fitting models, positive genetic overlap played an important role in this association at all stages. A negative causal effect running from ADHD symptoms to emotional problems was also detected in early childhood and mid-childhood. When distinguishing ADHD subdomains, the apparent protective effect of ADHD symptoms on emotional problems in childhood was mostly driven by hyperactivity-impulsivity.

Conclusions

Genetic overlap plays an important role in the association between ADHD symptoms and emotional problems. Hyperactivity-impulsivity may protect children from emotional problems in childhood, but this protective effect diminishes after adolescence.
Developing a data analytics toolbox for data-driven product planning: a review and survey methodology
Authors: Panzner Melina , von Enzberg Sebastian , Dumitrescu Roman
Published: November 2024

The application of data analytics to product usage data has the potential to enhance engineering and decision-making in product planning. To achieve this effectively for cyber-physical systems (CPS), it is necessary to possess specialized expertise in technical products, innovation processes, and data analytics. An understanding of the process from domain knowledge to data analysis is of critical importance for the successful completion of projects, even for those without expertise in these areas. In this paper, we set out the foundation for a toolbox for data analytics, which will enable the creation of domain-specific pipelines for product planning. The toolbox includes a morphological box that covers the necessary pipeline components, based on a thorough analysis of literature and practitioner surveys. This comprehensive overview is unique. The toolbox based on it promises to support and enable domain experts and citizen data scientists, enhancing efficiency in product design, speeding up time to market, and shortening innovation cycles.
An analysis of benefit distributions selected by individuals covered by the PBGC: differences by sex and age
Authors: Clark Robert L. , Pelletier Denis , Ritter Beth M.
Published: November 2024

The Pension Benefit Guaranty Corporation (PBGC) becomes the trustee for private defined benefit plans that have defaulted. The PBGC pays retirement benefits as provided by the plan and that are consistent with federal guidelines concerning the type and amounts of distributions. In response to a Freedom of Information Request, the PBGC provided us with relevant information on all individuals who received retirement benefits from the PBGC in the last 10 years, over 250,000 retirees. Individuals requesting payouts from PBGC managed plans have the option of selecting either a single-life annuity or a joint-and-survivor (J&S) annuity. We examine the PBGC distributions chosen over the last decade and how they vary by age at retirement, sex, months of service, and other relevant variables. Key findings indicate that men are much more likely to choose a joint and survivor annuity compared to female claimants, and the difference increases with age. Conditional on selecting a J&S annuity, men are more likely to select a 100 percent survivor's annuity, while women tend to choose a 50 percent survivor's benefit.
Examining the Racial and Gendered Impacts of Police-Initiated Contacts on Help-Seeking
Authors: Zaykowski Heather , Massoudi Aria
Published: November 2024

It is well known that marginalized communities of color, particularly young Black men, are more likely to experience police-initiated contact that other groups. Research suggests that these events contribute to legal cynicism, or the belief that the law and its agencies are ineffective, unwilling to help, and untrustworthy. In turn, cynical orientations limit one’s willingness to call the police to help. However, recent work on marginalized women suggests that despite holding cynical attitudes towards the police, their immediate needs for safety and services supersede these beliefs. The current study examines the racialized and gendered linkages between police-initiated contact and help-seeking outcomes (reporting crime, calling for an emergency, and seeking help from police for non-emergencies). Using data from the Police Public Contact Survey (from the Police Public Contact Survey–2020) results indicate that Black and Hispanic participants were less likely than White participants to seek help. However, Black and Hispanic women were more likely than their male counterparts for calls for help regarding a crime or disturbance. Across all outcomes, police-initiated contact was associated with higher rates of help-seeking. Perceived illegitimacy of street stops reduced the odds of reporting crimes to the police. However, perceived traffic stop illegitimacy was not related to help-seeking. Police initiated contacts and perceptions of legitimacy did not moderate the relationships between demographic variables and help-seeking outcomes. Implications for theories on legal socialization and the impact of police-initiated contacts on help-seeking are discussed.
The Short Dark Tetrad (SD4)
Authors: Dinić Bojana M. , Buckels Erin E. , Kovačević Nataša
Published: November 2024

Abstract: This study aimed to test the construct and criterion validity of the Serbian adaptation of the Short Dark Tetrad (SD4). In addition to testing measurement invariance between the Serbian ( N = 488) and Canadian samples ( N = 739), the construct validity of the SD4 was also assessed through correlations with more extensive measures of the Dark Tetrad, and criterion validity was evaluated through correlations with variables related to mental health. The results indicated good model fit indices for the SD4 in both samples and partial scalar invariance across samples. Validity correlations with extensive measures confirmed the construct validity of all SD4 scales, with caution noted for the psychopathy scale, which shares similar content with sadism. Profile similarity, based on construct and criterion correlations, revealed substantial dissimilarity between narcissism and the other scales but high similarity among the Machiavellianism, psychopathy, and sadism scales. Regardless of the similarity between the scales, they showed distinctive correlations with emotional distress and positive mental health aspects.
Introducing the I-SEE-DE-12
Authors: Miczka Julia , Heinecke-Müller Michaela , Boer Diana
Published: November 2024

Abstract: Control as a core self-evaluation is crucial for processes of action, learning, development, adaptation, and well-being. There is a high demand for short questionnaires suitable for panels, especially during times of crisis. However, one- or two-dimensional measures may obscure the complexity of this construct, particularly from a transcultural perspective. Krampen (1991) developed the German Inventory for Self-efficacy and Externality (I-SEE), comprising 32 items and four primary scales (self-concept of ability, internality, powerful others, and chance) within internal and external domains. This paper introduces and evaluates an abbreviated 12-item version. In two independent samples, the I-SEE-DE-12 demonstrated sufficient internal consistency, test–retest reliability, and adequate construct reliability. Information on convergent and discriminant validity is presented, confirming its correspondence with the longer version. The original factor structure was replicated up to the level of secondary factors. A single-factor model did not fit adequately in the German representative reference sample, further confirming the distinctiveness of four control aspects in two independent control belief domains. Implications for transcultural advancements of the measure and limitations of the current version are discussed.
Whose Priorities? Examining Inequities in Earth Observation Advancements Across Africa
Authors: Nakalembe Catherine , Devereux Taryn , Ginsburg Alana
Published: November 2024

Earth Observation (EO) technology continues to gain momentum for applications like crop monitoring and food security mapping across Africa. However, the development of these systems and the direction of the sector, even for locally relevant data sets, applications, and solutions, has been and remains largely externally driven. We utilized a database of ”leading organizations” in EO for Machine Learning” and partnerships in African space programs to investigate the landscape of EO for Agriculture in Africa. We analyze key actors based on origin, activities, funding sources, and other factors. Results reveal an imbalance where most African EO activities are directed by non‐African entities, highlighting data sovereignty issues and the need for enhanced local capacity building. Across the EO pipeline, African participation and leadership are limited despite national efforts to launch satellites and expand space programs. Analysis of a sample of organizations involved in the EO sector worldwide showed that 71% had active initiatives focused on the continent, despite only one organization being headquartered locally. Only around 1/3 of active satellites for African countries were contracted locally, and reports show that users face barriers to accessing their data. By mapping participation and funding flows, this research elucidates how African countries can exert greater control over EO data, build sustainable expertise, and harness EO technology to serve national development priorities. As the EO sector evolves rapidly, African voices must help shape the applications and priorities for these powerful technologies.
The Influence of Surface Fluxes on Export of Southern Ocean Intermediate and Mode Water in Coupled Climate Models
Authors: Almeida Lucas , Mazloff Matthew R. , Mata Mauricio M.
Published: November 2024

The Southern Ocean (SO) plays a crucial role in the process of sequestering heat and carbon dioxide from the atmosphere and transferring them to the deep ocean. This process is intricately linked to the formation of Antarctic Intermediate Water (AAIW) and Subantarctic Mode Water (SAMW), which are pivotal components of the Meridional Overturning Circulation (MOC) and have a substantial impact on the global climate balance. AAIW and SAMW take shape in specific regions of the Southern Ocean due to the influence of strong winds, buoyancy fluxes, and their effects, such as convection, the development of thick mixed layers, and wind‐driven subduction. These water masses subsequently flow northward, contributing to the ventilation of the intermediate layers within the subtropical gyres. In this study, our focus lies on investigating the regional aspects of AAIW and SAMW transformation in CMIP6 models. We accomplish this by analyzing the relationship between the meridional transport of these water masses and air‐sea fluxes, particularly Ekman pumping, freshwater fluxes, and heat fluxes. Our findings reveal that the highest transformation rates occur in the Indian sector of the Southern Ocean, with notable values also observed in the southeast Pacific and south of Africa. Additionally, we assess the potential changes in these formation regions under future scenarios projected for the end of the 21st century. Although the patterns of formation regions remain consistent, there is a significant decrease in the transformation process.
A worldwide study of subcortical shape as a marker for clinical staging in Parkinson’s disease
Authors: Laansma Max A. , Zhao Yuji , van Heese Eva M. , Bright Joanna K. , Owens-Walton Conor , Al-Bachari Sarah , Anderson Tim J. , Assogna Francesca , van Balkom Tim D. , Berendse Henk W. , Cendes Fernando , Dalrymple-Alford John C. , Debove Ines , Dirkx Michiel F. , Druzgal Jason , Emsley Hedley C. A. , Fouche Jean-Paul , Garraux Gaëtan , Guimarães Rachel P. , Helmich Rick C. , Hu Michele , van den Heuvel Odile A. , Isaev Dmitry , Kim Ho-Bin , Klein Johannes C. , Lochner Christine , McMillan Corey T. , Melzer Tracy R. , Newman Benjamin , Parkes Laura M. , Pellicano Clelia , Piras Fabrizio , Pitcher Toni L. , Poston Kathleen L. , Rango Mario , Ribeiro Leticia F. , Rocha Cristiane S. , Rummel Christian , Santos Lucas S. R. , Schmidt Reinhold , Schwingenschuh Petra , Squarcina Letizia , Stein Dan J. , Vecchio Daniela , Vriend Chris , Wang Jiunjie , Weintraub Daniel , Wiest Roland , Yasuda Clarissa L. , Jahanshad Neda , Thompson Paul M. , van der Werf Ysbrand D. , Gutman Boris A.
Published: November 2024

Alterations in subcortical brain regions are linked to motor and non-motor symptoms in Parkinson’s disease (PD). However, associations between clinical expression and regional morphological abnormalities of the basal ganglia, thalamus, amygdala and hippocampus are not well established. We analyzed 3D T1-weighted brain MRI and clinical data from 2525 individuals with PD and 1326 controls from 22 global sources in the ENIGMA-PD consortium. We investigated disease effects using mass univariate and multivariate models on the medial thickness of 27,120 vertices of seven bilateral subcortical structures. Shape differences were observed across all Hoehn and Yahr (HY) stages, as well as correlations with motor and cognitive symptoms. Notably, we observed incrementally thinner putamen from HY1, caudate nucleus and amygdala from HY2, hippocampus, nucleus accumbens, and thalamus from HY3, and globus pallidus from HY4–5. Subregions of the thalami were thicker in HY1 and HY2. Largely congruent patterns were associated with a longer time since diagnosis and worse motor symptoms and cognitive performance. Multivariate regression revealed patterns predictive of disease stage. These cross-sectional findings provide new insights into PD subcortical degeneration by demonstrating patterns of disease stage-specific morphology, largely consistent with ongoing degeneration.
Adipose tissue retains an epigenetic memory of obesity after weight loss
Authors: Hinte Laura C. , Castellano-Castillo Daniel , Ghosh Adhideb , Melrose Kate , Gasser Emanuel , Noé Falko , Massier Lucas , Dong Hua , Sun Wenfei , Hoffmann Anne , Wolfrum Christian , Rydén Mikael , Mejhert Niklas , Blüher Matthias , von Meyenn Ferdinand
Published: November 2024

Reducing body weight to improve metabolic health and related comorbidities is a primary goal in treating obesity1,2. However, maintaining weight loss is a considerable challenge, especially as the body seems to retain an obesogenic memory that defends against body weight changes3,4. Overcoming this barrier for long-term treatment success is difficult because the molecular mechanisms underpinning this phenomenon remain largely unknown. Here, by using single-nucleus RNA sequencing, we show that both human and mouse adipose tissues retain cellular transcriptional changes after appreciable weight loss. Furthermore, we find persistent obesity-induced alterations in the epigenome of mouse adipocytes that negatively affect their function and response to metabolic stimuli. Mice carrying this obesogenic memory show accelerated rebound weight gain, and the epigenetic memory can explain future transcriptional deregulation in adipocytes in response to further high-fat diet feeding. In summary, our findings indicate the existence of an obesogenic memory, largely on the basis of stable epigenetic changes, in mouse adipocytes and probably other cell types. These changes seem to prime cells for pathological responses in an obesogenic environment, contributing to the problematic ‘yo-yo’ effect often seen with dieting. Targeting these changes in the future could improve long-term weight management and health outcomes.
Probe set selection for targeted spatial transcriptomics
Authors: Kuemmerle Louis B. , Luecken Malte D. , Firsova Alexandra B. , Barros de Andrade e Sousa Lisa , Straßer Lena , Mekki Ilhem Isra , Campi Francesco , Heumos Lukas , Shulman Maiia , Beliaeva Valentina , Hediyeh-Zadeh Soroor , Schaar Anna C. , Mahbubani Krishnaa T. , Sountoulidis Alexandros , Balassa Tamás , Kovacs Ferenc , Horvath Peter , Piraud Marie , Ertürk Ali , Samakovlis Christos , Theis Fabian J.
Published: November 2024

Targeted spatial transcriptomic methods capture the topology of cell types and states in tissues at single-cell and subcellular resolution by measuring the expression of a predefined set of genes. The selection of an optimal set of probed genes is crucial for capturing the spatial signals present in a tissue. This requires selecting the most informative, yet minimal, set of genes to profile (gene set selection) for which it is possible to build probes (probe design). However, current selections often rely on marker genes, precluding them from detecting continuous spatial signals or new states. We present Spapros, an end-to-end probe set selection pipeline that optimizes both gene set specificity for cell type identification and within-cell type expression variation to resolve spatially distinct populations while considering prior knowledge as well as probe design and expression constraints. We evaluated Spapros and show that it outperforms other selection approaches in both cell type recovery and recovering expression variation beyond cell types. Furthermore, we used Spapros to design a single-cell resolution in situ hybridization on tissues (SCRINSHOT) experiment of adult lung tissue to demonstrate how probes selected with Spapros identify cell types of interest and detect spatial variation even within cell types.
Band structure database of layered intercalation compounds with various intercalant atoms and layered hosts
Authors: Kawaguchi Naoto , Shibata Kiyou , Mizoguchi Teruyasu
Published: November 2024

Here we provide a database comprising electronic band structures of 9,004 layered intercalation compounds, where atoms are intercalated into a host layered compound with different intercalant atoms, along with 468 structures related to the layered host compounds. Additionally, we provide properties derived from the electronic states such as band gap as well as stability-related properties like formation energies. Direct comparison of the band structures before and after intercalation is generally challenging due to changes in their space group and k-path. However, in this study, we developed new k-paths consistent with the host materials, allowing for the direct comparison of band structures before and after intercalation. This enables direct and quantitative discussion of the band structure changes induced by the intercalations and provides a valuable database for intercalant-driven band engineering. Layered intercalation compounds are widely used in many fields, including superconductivity and energy applications, and understanding of electronic structures is necessary. The feature of our database holds promises for the development of layered compounds with enhanced functionalities through database utilization.
Performance of the comprehensive nutrition screening index in predicting mortality after cardiac surgery
Authors: Chung Jaeyeon , Bae Jinyoung , Park Seyong , Kim Dong Hyouk , Cho Youn Joung , Nam Karam , Jeon Yunseok , Ju Jae-Woo
Published: November 2024

Malnutrition is a significant risk factor for postoperative outcomes in patients undergoing cardiac surgery. The Seoul National University Hospital-Nutrition Screening Index (SNUH-NSI) is an automated screening tool designed to comprehensively assess malnutrition risk. However, its predictive value in patients undergoing cardiac surgery remains unvalidated. This study included adult patients who underwent cardiac surgery at a tertiary teaching hospital between May 2008 and December 2019. Patients were classified as low-, intermediate-, or high-risk for malnutrition based on the SNUH-NSI. The association between malnutrition risk and postoperative cumulative all-cause mortality was evaluated using multivariable Cox regression analysis. The predictive ability of the SNUH-NSI was compared with conventional nutritional indices. Compared to the low-risk group, both the high-risk (adjusted hazard ratio [HR], 2.64; 95% confidence interval [CI], 2.19–3.19; P < 0.001) and intermediate-risk groups (adjusted HR, 1.54; 95% CI, 1.31–1.82; P < 0.001) demonstrated a significantly elevated risk of cumulative all-cause mortality. The multivariable model incorporating SNUH-NSI demonstrated moderate but superior predictive performance compared to that of other conventional nutritional indices. Preoperative malnutrition assessed by the SNUH-NSI was found to be a significant predictor of mortality following cardiac surgery. Implementing the SNUH-NSI for automated preoperative malnutrition screening could be an efficient and cost-effective approach.
Tumor-derived extracellular vesicles disrupt the blood–brain barrier endothelium following high-frequency irreversible electroporation
Authors: Murphy Kelsey R. , Aycock Kenneth N. , Marsh Spencer , Hay Alayna N. , Athanasiadi Ilektra , Bracha Shay , Chang Christine , Gourdie Robert , Davalos Rafael V. , Rossmeisl John H. , Dervisis Nikolaos G.
Published: November 2024

High-frequency irreversible electroporation (H-FIRE), a nonthermal brain tumor ablation therapeutic, generates a central tumor ablation zone while transiently disrupting the peritumoral blood–brain barrier (BBB). We hypothesized that bystander effects of H-FIRE tumor cell ablation, mediated by small tumor-derived extracellular vesicles (sTDEV), disrupt the BBB endothelium. Monolayers of bEnd.3 cerebral endothelial cells were exposed to supernatants of H-FIRE or radiation (RT)-treated LL/2 and F98 cancer cells. Endothelial cell response was evaluated microscopically and via flow cytometry for apoptosis. sTDEV were isolated following H-FIRE and RT, characterized via nanoparticle tracking analysis (NTA) and transmission electron microscopy, and applied to a Transwell BBB endothelium model to quantify permeability changes. Supernatants of H-FIRE-treated tumor cells, but not supernatants of sham- or RT-treated cells, disrupted endothelial cell monolayer integrity while maintaining viability. sTDEV released by glioma cells treated with 3000 V/cm H-FIRE increased permeability of the BBB endothelium model compared to sTDEV released after lower H-FIRE doses and RT. NTA revealed significantly decreased sTDEV release after the 3000 V/cm H-FIRE dose. Our results demonstrate that sTDEV increase permeability of the BBB endothelium after H-FIRE ablation in vitro. sTDEV-mediated mechanisms of BBB disruption may be exploited for drug delivery to infiltrative margins following H-FIRE ablation.
Blink-induced changes in pupil dynamics are consistent and heritable
Authors: Demiral Şükrü Barış , Volkow Nora D.
Published: November 2024

Pupil size and blink rates are heritable but the extent to which they interact with one another has not been properly investigated. Though changes in pupil size due to eye blinks have been reported, they are considered a pupillary artifact. In this study we used the HCP 7T fMRI dataset with resting state eye-tracking data obtained in monozygotic and dizygotic twins to assess their heritability and their interactions. For this purpose, we characterized the pupil dilation (positive peak) and constriction (negative peak) that followed blink events, which we describe as blink-induced pupillary response (BIPR). We show that the BIPR is highly consistent with a positive dilatory peak (D-peak) around 500ms and a negative constricting peak (C-peak) around 1s. These patterns were reproducible within- and between-subjects across two time points and differed by vigilance state (vigilant versus drowsy). By comparing BIPR between monozygotic and dizygotic twins we show that BIPR have a heritable component with significant additive genetic (A) and environmental (E) factors dominating the structural equation models, particularly in the time-domain for both D- and C-peaks (a2 between 42 and 49%) and shared effects (C) as observed in the amplitude domain for the C-peak. Blink duration, pupil size and blink rate were also found to be highly heritable (a2 up to 62% for pupil size). Our study provides evidence of that shared environmental and additive genetic factors influence BIPR and indicates that BIPR should not be treated as a coincidental artefact. Instead BIPR appears to be a component of a larger oculomotor system that we label here as Oculomotor Adaptive System, that is genetically determined.
Contact toxicity of insecticides against rice weevil, Sitophilus oryzae L. and its effect on progeny production
Authors: Rajarushi C. N. , Nebapure Suresh M. , Biswas Ankur , Rajna S. , Subramanian S.
Published: November 2024

Post-harvest losses caused by insect pests, particularly the rice weevil, Sitophilus oryzae, pose a significant challenge in food storage facilities worldwide. To combat this pest, synthetic insecticides and fumigants are widely used. However, effective contact insecticides are scarce. Hence, the present study explored the alternatives by evaluating the contact toxicity of various insecticides against S. oryzae using glass, jute, and floor tiles as surface substrates and further examining the effect on progeny production of promising candidate insecticides. Among the insecticides tested, malathion exhibited the highest toxicity on glass and jute surfaces regardless of the exposure period. On the other hand, spinetoram proved to be the most effective on tile surface with an 8 h exposure period. Among the alternate insecticides (spinosad, spinetoram, chlorfenapyr and lambda-cyhalothrin), spinetoram was most effective with LC50 values of 155.8 and 116.9 mg/m² for 4 h and 8 h exposure, respectively, on tile surface; 204.6 and 129.0 mg/m² for 4 h and 8 h exposure, respectively, on glass surface; and 271.5 and 199.5 mg/m² for 4 h and 8 h exposure, respectively, on jute surface. Relative toxicity assessments revealed spinetoram to be 2.11 and 2.51 times more effective than deltamethrin on tile surface for 4 and 8 h of exposure, respectively whereas it was 1.14 times more effective than malathion on tile surface at 8 h exposure. Principal component analysis indicated a higher demand for insecticide doses closely associated with the structural properties of surfaces, particularly evident with jute surfaces. Furthermore, the effect on adult mortality and progeny production by malathion, spinetoram, and lambda-cyhalothrin revealed malathion as the most effective insecticide followed by spinetoram. Carboxylesterase, acetylcholinesterase, and Glutathione S-transferase (GST) activities were notably higher in deltamethrin-treated insects compared to other insecticides. The studies concluded that spinetoram can be considered an alternative to conventional insecticides for the management of S. oryzae under different storage conditions.