bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical and anamnestic factors of recurrent endometrial polyps in fertile age
Authors:   Patrice Lumumba Peoples' Friendship University of Russia, Orazov Mekan R. Orazov , Khamoshina Marina B. ,   Patrice Lumumba Peoples' Friendship University of Russia, Poimanova Olga F. ,   Patrice Lumumba Peoples' Friendship University of Russia, Mullina Irina A. ,   Patrice Lumumba Peoples' Friendship University of Russia, Artemenko Yuliia S. ,   Patrice Lumumba Peoples' Friendship University of Russia
Published: June 2024

The prevalence of endometrial polyps (EP) ranges from 7.8 to 34.9%, and in the group of patients with symptoms reaches 24%. The natural course of EP is unclear, the frequency of spontaneous regression of EP varies from 6.3% to 57.1%, but it is impossible to accurately predict the nature of the growth of an individual polyp and the probability of regression. A successful operation does not guarantee against recurrence of the disease: according to various authors, the frequency of postoperative recurrence of EP varies from 5.6% to 43.6%, depending on the duration of observa-tion and the nature of polyps. To improve the results of EP treatment, to determine the target groups for hysteroscopic polypectomy, it is impor-tant to have an understanding of the risk factors for recurrence of EP. The analysis of scientific publications in the databases eLibrary, PubMed, Cochrane Library, Science Direct was performed, according to the keywords endometrial polyps/endometrial polyp, recurrence/recurrence, risk factors/risk factors, reproductive age/reproductive age, premenopausal age/premenopausal age for 2013–2023. The obtained results of the liter-ature analysis allow us to conclude about the influence of age, multiple nature of polyps, chronic endometritis on the risk of recurrence of EP. In addition, other factors may be involved in the development of recurrent polyps. For a more accurate assessment of the contribution of various risk factors to the recurrence of EP, it is necessary to perform high-quality scientific research. The purpose of the work: to analyze the available literature data and summarize the information received to date on the clinical and anamnestic risk factors of EP.
Clinical and anamnestic portrait of patient with genital prolapse
Authors:   Patrice Lumumba Peoples' Friendship University of Russia, Toktar Liliya R. , Orazov Mekan R. ,   Patrice Lumumba Peoples' Friendship University of Russia, Lologaeva Milana S. ,   Patrice Lumumba Peoples' Friendship University of Russia, Ariutin Dmitrii G. ,   Patrice Lumumba Peoples' Friendship University of Russia, Samsonova Irina A. ,   Patrice Lumumba Peoples' Friendship University of Russia, Gaifullin Rustam F. ,   Patrice Lumumba Peoples' Friendship University of Russia, Dostieva Shakhlo M. ,   Patrice Lumumba Peoples' Friendship University of Russia, Kamarova Zarina N. ,   Patrice Lumumba Peoples' Friendship University of Russia
Published: June 2024

Background. Pelvic organ prolapse (POP) is one of the most common and poorly understood gynecological diseases that is reported in 60% of women, and this indicator shows no downward trend. There is still no consensus on etiology and pathogenesis of genital prolapse (GP), despite numerous studies and hypotheses. Determining predictors of POP, allocating groups at high risk are among the key links of preventive strategy for management of patients with POP. Aim. To expand the knowledge about the risk factors of POP, determine the clinical and anamnestic portrait of woman with genital GP. Methods. The prospective cohort study was carried out in 2018–2020 at the Department of Obstetrics and Gynecology with Perinatology Course, Institute of Medicine, Peoples' Friendship University of Russia. The study involved 110 patients divided into groups based on the GP severity (group I – vaginal prolapse, group II – incomplete uterine prolapse, group III – complete uterine prolapse). Results. When studying the patients’ clinical and anamnestic characteristics, it was found that the groups were comparable based on all major parameters. There were significant age differences between patients (p<0.05): elderly women were most often found in the group with complete uterine prolapse (group III). There were no significant differences (p>0.05) in social status, tobacco smoking, allergic reactions to medication, BMI, menarche, menstruation duration in all groups. Assessment of parity showed that the groups were comparable. Evaluation of extragenital diseases showed that there was a predictably larger number of patients with hypertension in group III, which was reflected by significant inter-group differences (p<0.05). The analysis of comorbidities also revealed a relatively small share of women with varicose veins, osteochondrosis, bronchial asthma and chronic bronchitis, which was confirmed by the lack of significant differences (p>0.05). Conclusion. Allocation of groups at high risk of severe POP based on clinical and anamnestic predictors is the most important aspect of preven-tion and prediction of GP. Such targeted approach will make it possible to prevent prolapse progression to advanced stages and improve the out-comes of conservative and surgical treatment of patients.
Perineal thread lifting in aesthetic gynecology: on the way from compromise to the golden mean
Authors:   Patrice Lumumba Peoples' Friendship University of Russia, Orazov Mekan R. , Radzinskii Viktor E. ,   Patrice Lumumba Peoples' Friendship University of Russia, Dolgov Evgenii D. ,   Patrice Lumumba Peoples' Friendship University of Russia
Published: June 2024

Pelvic floor dysfunction found in women regardless of their age has long been and remains one of the most controversial issues of modern gyne-cology. Numerous correction methods, from extensive surgical interventions to minimally invasive approaches, have been often opposed one an-other. However, to date we have formulated a clear recommendation: defects of the pelvic fascia and pelvic floor muscle compartment are the un-contested imperative indications for reconstructive surgery. Meanwhile, the issue of correcting early signs of pelvic floor dysfunction in patients with no myofascial defects is still a matter of debate, since surgical correction is often impossible or even more often not feasible in such cases. In this regard, it is necessary to consider perineal thread lifting as one of the most advanced and effective methods for treatment of the gaping vaginal opening that does not require surgical correction.
Optimizing the provision of micronutrient support for pregnant women and nursing mothers to reduce gestational complications and perinatal mordability (literature review)
Authors:   Far Eastern State Medical University, Pestrikova Tatyana Yu. , Yurasova Elena A. ,   Far Eastern State Medical University, Yurasov Igor V. ,   Far Eastern State Medical University
Published: June 2024

Relevance. Preconception preparation is carried out by only 4% of women who come to see a gynecologist at the stage of pregnancy planning. Accordingly, there is no need to talk seriously about the system of prenatal preparation. Therefore, all the negative consequences of insufficient and malnutrition in women can have an adverse effect on the course of the gestational period and contribute to the formation of fetopathies and other complications in the fetus/newborn. Purpose. To raise awareness among obstetricians-gynecologists, reproductive specialists, pediatricians and other specialists about the medical and social significance of using micronutrient support at the stage of preconception preparation, during pregnancy and lactation. Materials and methods. To write this review, a search was carried out for domestic and foreign publications in Russian and international search systems (PubMed, eLibrary, etc.) over the past 30 years. The review included articles from the peer-reviewed literature. Results. The review presents data on the advisability of using micronutrient support drugs during pregnancy and lactation. Conclusions. The importance of awareness of outpatient obstetrician-gynecologists in the need for preconception preparation using the Preg-nakea Plus vitamin-mineral complex is emphasized.
New approaches on diabetes mellitus management
Authors:   Vladimirsky Moscow Regional Research Clinical Institute, Barsukov Ilya A. , Demina Anna A. ,   Vladimirsky Moscow Regional Research Clinical Institute
Published: June 2024

Diabetes mellitus is one of the most world’s common disease. Global digitalization reveals new opportunities in diabetes mellitus patient man-agement. Various applications and devices are currently available to improve patient’s glucose levels. Apart from continuous glucose monitoring devices traditional methods of blood glucose monitoring are widely used. The development of special applications and options for glucometers to connect with mobile devices essentially improved data analysis and allowed to improve treatment efficacy.
Hematological indices – a new marker of inflammation in old patients and centenarians with trophic ulcers of lower extremities
Authors:   Hospital for War Veterans, Topolyanskaya Svetlana V. ,   Sechenov First Moscow State Medical University (Sechenov University), Bubman Leonid I. ,   Hospital for War Veterans, Karpov Viktor V. ,   Hospital for War Veterans, Nechaev Aleksei I. ,   Hospital for War Veterans, Khan Stanislav O. ,   Hospital for War Veterans, Korshunova Mariia A. ,   Hospital for War Veterans, Melkonyan Georgii G. ,   Hospital for War Veterans, Ratchina Svetlana A. ,   Sechenov First Moscow State Medical University (Sechenov University), Dvoretsky Leonid I. ,   Sechenov First Moscow State Medical University (Sechenov University)
Published: June 2024

Aim. To study the significance of various hematological indices as markers of laboratory inflammatory activity in patients with trophic ulcers of the lower extremities and compare them with similar indices in old patients with coronary artery disease (CAD). Materials and methods. The study enrolled 256 patients; 166 patients with trophic ulcers – in the main group, 90 with CAD, but without ul-cers – in the comparison group. The main group consisted of 31.9% men and 68.1% women. The mean age of patients with trophic ulcers reached 80.8±10.1 years (from 61 to 101 years); 30.1% of patients were centenarians. The ratio of the number of neutrophils to lymphocytes (NLR), neu-trophils to monocytes (NMR), platelets to lymphocytes (PLR), lymphocytes to monocytes (LMR) and systemic immune-inflammation index (SII –platelet count хNLR) were determined. Results. The mean count of leukocytes in patients with trophic ulcers was 7.1±2.6×109/l, neutrophils – 4.7±2.3×109/l, lymphocytes –1.8±2.2×109/l, monocytes – 0.6±0.3×109/l, platelets – 278.5±110×109/l. The mean values of NLR in the group of patients with ulcers reached 3.6, NMR – 15.4, PLR – 214.1, LMR – 5.9, SII – 1102.3. In patients with trophic ulcers, the count of leukocytes (6.7×109/l and 5.9×109/l; p=0.002), neutrophils (4.2×109/l and 3.7×109/l; р=0.002) and platelets (252×109/l and 205×109/л; p<0.0001) was significantly higher than in the group of patients with CAD. NLR (2.7 and 2.1; p=0.003) and PLR (172 and 133; p<0.0001) in patients with trophic ulcers of the lower extremities was higher, but LMR was lower (2.8 and 3.1; p=0.01), than in patients with CAD. In the group of patients with trophic ulcers, the median of the SII reached 452, while in patients with CAD it was 296 (p=0.00003). The median of erythrocyte sedimentation rate in patients with the lower ex-tremities ulcers was 32 mm/h, in patients with CAD – 21 mm/h (p=0.00002).A direct relationship was registered between interleukin-6 level and leukocytes (r=0.32; p=0.01), neutrophils (r=0.36; p=0.005), platelets (r=0.36; p=0.006), NLR (r=0.30; p=0.02), PLR (r=0.27; p=0.03) and SII (r=0.31; p=0.01). Conclusions. The study results suggest that various hematological indices can be used as markers of laboratory inflammatory activity in patients with trophic ulcers of the lower extremities in the old age and centenarians.
"Always trendy". Neoclassic, or favorite endometriosis localizations
Authors:   Patrice Lumumba Peoples' Friendship University of Russia,, Orazov Mekan R. , Radzinskii Viktor E. ,   Patrice Lumumba Peoples' Friendship University of Russia,, Dolgov Evgenii D. ,   Patrice Lumumba Peoples' Friendship University of Russia,
Published: June 2024

Endometriosis continues to be an unsolved/unsolvable problem of modern gynecology. There are only 3 most common clinical phenotypes of this disorder: superficial peritoneal endometriosis, cystic ovarian endometriosis and deeply infiltrative endometriosis. In view of significantly reduced quality of life in patients with endometriosis resulting from algological symptoms and endometriosis-associated infertility, it is necessary to consider the features of clinical management of a patient with the “favorite” endometriosis localization to provide effective clinical management and improve the therapy efficacy.
Recurrent endometrial hyperplasia without atypia: how to escape the vicious circle?
Authors:   Patrice Lumumba Peoples' Friendship University of Russia, Orazov Mekan R. , Radzinskii Viktor E. ,   Patrice Lumumba Peoples' Friendship University of Russia, Khamoshina Marina B. ,   Patrice Lumumba Peoples' Friendship University of Russia, Dolgov Evgenii D. ,   Patrice Lumumba Peoples' Friendship University of Russia, Mullina Irina A. ,   Patrice Lumumba Peoples' Friendship University of Russia, Artemenko Yuliia S. ,   Patrice Lumumba Peoples' Friendship University of Russia
Published: June 2024

Today, endometrial hyperplasia (EH) is among the most relevant gynecological entities. Arterial hypertension, diabetes mellitus and obesity, the combination of which is referred to as metabolic syndrome, are the key risk factors of EH. The incidence of EH and endometrial cancer grows proportionally based on the rapid increase in the prevalence of this set of symptoms among patients in the 21st century. Currently, there is a clear histological gradation of EH into atypical form and EH without atypia, which represents a key factor of the clinical management strategy (conser-vative or surgical) determination. However, high EH relapse rate after conservative treatment is the most important challenge of EH. In this re-gard, it is necessary to consider modern options for prevention of recurrent EH without atypia in patients of different ages.
Recurrent aphthosic stomatitis: rebamipide – a new direction in treatment and prevention
Authors:   Omsk State Medical University, Trukhan Dmitry I. , Sulimov Anatoly F. ,   Omsk State Medical University, Trukhan Larisa Yu. ,   Omsk State Medical University
Published: June 2024

Recurrent aphthous stomatitis (RAS) is a widespread disease worldwide, accompanied by the appearance of painful aphthae on the oral mucosa. RAS is a multifactorial disease. Local and systemic factors such as trauma, food sensitivities, nutritional deficiencies, systemic conditions, immunological disorders and genetic polymorphisms are associated with its development. Studies examining the possible connection between the development of RAS and Helicobacter pylori infection are reviewed. The review examined publications on the use of the universal gastro- and enteroprotector rebamipide as a new direction in the treatment and prevention of RAS. Clinical data clearly establish the safety and effectiveness of rebamipide in the treatment of RAS and Behçet's disease. The benefits of rebamipide for RAS include: reduced pain duration, accelerated healing and reduced relapse rates. Aphthous stomatitis (oral mucositis) can be induced by chemotherapy and radiation therapy in oncology practice, with an incidence reaching 100% in patients receiving high-dose chemotherapy and up to 80% of patients receiving radiation therapy. A number of studies in its treatment and prevention have also demonstrated the effectiveness and safety of systemic and local use of rebamipide. The presented review expands the scope of rebamipide, suggesting the possibility of its use in dental and oncological practice for the treatment and prevention of RAS, including Behcet's disease, and oral mucositis.
Safety issues of antiarrhythmic therapy for atrial fibrillation
Authors:   Ural State Medical University, Reznik I.I. , Bozhko Ya.G. ,   Ural State Medical University
Published: June 2024

The article discusses the safety of antiarrhythmic therapy for atrial fibrillation in the light of the development of cardiac and non-cardiac side effects, the presence of drug-drug interactions of antiarrhythmic drugs in the near (with anticoagulants) and far circle. The features of the choice of antiarrhythmic therapy for the prevention of relapses of atrial fibrillation, restoration of sinus rhythm, as well as heart rate control are presented, and aspects of the tactics of managing these patients are highlighted.
Review Drug safety: focus on long-term therapy with proton pump inhibitors. Probable side effects
Authors:   Omsk State Medical University, Trukhan Dmitry I.
Published: June 2024

Currently, an important component of rational pharmacotherapy is drug safety. Proton pump inhibitors (PPIs) are the most effective drugs for the treatment of acid-related diseases. For a long time, PPIs were considered completely safe drugs for both short-term and long-term use. However, modern clinical guidelines note that when prescribing PPIs in large doses for a long period, the possibility of side effects should be taken into account. In recent years, a number of foreign reviews have been published that examine the connections between PPIs and a number of diseases/conditions, but in the domestic literature there are no reviews on the safety of PPIs during long-term use. A search was conducted in the PubMed and Scopus information databases for publications on the safety of PPI use, including sources up to November 15, 2023. However, long-term use of PPIs is associated with numerous side effects, and it is not possible to discuss all of them in detail in one review. This review examines the most likely side effects associated with long-term PPI therapy: the development of infections, increased risk of fractures and kidney pathology. The association of long-term use of PPIs with the development of these side effects is not denied or questioned in recent reviews.
Fixed-dose combination drugs containing vitamins: two-step therapy of pain syndrome
Authors:   nternational University of Restorative Medicine, Shavlovskaya Olga A.
Published: June 2024

Simple analgesics, non-steroidal anti-inflammatory drugs (NSAIDs), muscular and epidural blocks are most often prescribed to relieve acute pain. However, the use of a number of drugs is associated with the development of unwanted side effects. Furthermore, in some cases the need for both symptomatic and pathogenetic therapy necessitates the prescription of combination treatment involving drugs that exert metabolic effects. The paper discusses the role of metabolic therapy in patients with pain syndrome exemplified by the drugs containing B vitamins. Emphasis is placed on the two-step therapy of pain syndrome.
Сlinical case of congenital pathology of the central nervous system: multicystic transformation of the cerebral hemispheres (encephalomalacia), internal hydrocephalus
Authors:   Kursk State Medical University, Serezhkina Alexandra V. , Khmelevskaya Irina G. ,   Kursk State Medical University, Razinkova Natalya S. ,   Kursk State Medical University, Minenkova Tatyana A. ,   Kursk State Medical University, Zhiznevskaya Irina I. ,   Kursk State Medical University, Bezykina Anzhelika A. ,   Kursk State Medical University, Zubtsova Maria S. ,   Kursk State Medical University, Gromov Rostislav E. ,   Kursk State Medical University
Published: June 2024

A case of multicystic encephalomalacia in a deceased child aged 1 month 17 days is presented. The dynamics describes changes in the general condition of the child, morphofunctional changes in the brain. The tactics of treatment and resuscitation measures in dynamics are given. A rare case of the formation of huge cysts of both hemispheres of the brain in a child born with an intrauterine cytomegalovirus infection is presented. In this observation, the relationship between a congenital infection and hypoxic dysfunction and morphology of the cerebral hemispheres is considered.
Clinical Case Clinical presentation of secondary syphilis in HIV-infected patients
Authors:   Russian University of Medicine, Glebova Larisa I. , Zadionchenko Ekaterina V. ,   Russian University of Medicine, Shalaginova Anna V. ,   Moscow Scientific and Practical Center for dermatology and Cosmetology branch “Clinic V.G. Korolenko"
Published: June 2024

Predominantly sexually transmitted infections (STIs) continue to be of concern to physicians. Particularly interesting are cases of combined STIs. Patients infected with human immunodeficiency virus (HIV) and other diseases pose the most challenging diagnostic and treatment scenarios. Venereologists observe severe manifestations of chronic dermatoses in individuals with HIV infection, atypical courses of other infections, and lack of response to conventional treatment methods. This study focuses on monitoring HIV-infected patients with syphilis during their hospitalization in the venereology department of the V.G. Korolenko Clinic, a branch of the State Budgetary Healthcare Institution Moscow Research and Practical Center for Dermatovenerology and Cosmetology. The study presents a differential diagnosis of secondary syphilis manifestations in these patients and discusses the peculiarities of the disease course.
Criteria for evaluation of the anticoagulant therapy efficacy: the role of «surrogate criteria»
Authors:   Pirogov Russian National Research Medical University, Gilyarevsky Sergey R.
Published: June 2024

The article is devoted to the problem of using indirect indicators, or surrogate criteria, both in randomized clinical and observational studies. The reasons for the increasing frequency of using surrogate criteria in assessing the results of clinical trials are considered. The possible negative consequences of the widespread use of proxy measures and the need to educate clinicians to obtain evidence-based information using surrogate criteria rather than true clinical outcomes are discussed. Data from analyzes aimed at identifying the most important problems in the use of surrogate criteria in assessing the effectiveness of certain interventions are presented. The problem of using surrogate criteria in assessing the effectiveness and safety of the use of anticoagulants in patients with atrial fibrillation or venous thromboembolic complications is separately considered. The necessary conditions are provided to ensure the possibility of using surrogate criteria in studies assessing the effectiveness of interventions. Examples of the use of both justified and insufficiently justified use of surrogate criteria for assessing the effectiveness of anticoagulants in various clinical situations are considered. The results of a randomized clinical trial evaluating the effectiveness of an anticoagulant based on identifying surrogate criteria for atrial fibrillation using devices implanted in the heart are discussed. The problem of using surrogate criteria when assessing the risk of bleeding in studies assessing the effects of anticoagulants is discussed separately. The opinions of experts are presented, emphasizing the need for careful use of surrogate criteria when assessing the incidence of both venous thromboembolic complications and bleeding, since in such cases the results of comparing the benefits and risks of the intervention can be significantly distorted.
Comorbidity of dyslipidemia and periodontal diseases
Authors:   Omsk State Medical University, Trukhan Dmitry I. , Sulimov Anatoly F. ,   Omsk State Medical University, Trukhan Larisa Yu.
Published: June 2024

Dyslipidemia – increased blood levels of cholesterol, triglycerides and atherogenic lipoproteins and/or decreased levels of anti-atherogenic high-density lipoproteins. Dyslipidemia is considered one of the main biological risk factors for chronic non-communicable diseases, along with overweight and obesity, arterial hypertension and hyperglycemia. The initial stage of correction of dyslipidemia begins with dietary recommendations, in which omega-3 polyunsaturated fatty acids occupy an important place. The effects of the main substances included in the combined nutraceutical Cholesterol Control are considered: omega-3 polyunsaturated fatty acids, including eicosapentaenoic and docosahexaenoic acids, red yeast rice, coenzyme Q10, which allows us to consider it the nutraceutical of choice for low and moderate risk individuals with moderately elevated cholesterol and triglycerides, no indications for taking statins or the presence of contraindications to taking them. Periodontitis is the sixth most common disease in the world (second among dental pathologies after caries) and the leading cause of tooth loss in adults. At the beginning of the 21st century, the concept of “periodontal medicine” was formed, within the framework of which the bidirectional connection of periodontal pathology with systemic diseases of the body is considered. We searched the PubMed and Scopus information databases for articles published before 02/15/2024 that examined the relationship between dyslipidemia and periodontal pathology. The results obtained indicate the presence of a bidirectional relationship between dyslipidemia and periodontal pathology. The analysis showed the positive effect of omega-3 polyunsaturated fatty acids and coenzyme Q10 on the inflammatory process in periodontal tissue and allows us to consider the nutraceutical Cholesterol Control as an adjuvant therapy in comorbid patients with dyslipidemia and periodontal pathology, as well as for the prevention of lipid disorders in patients with periodontal diseases.
Incidence and prevalence of pulmonary arterial hypertension associated with systemic lupus erythematosus. A systematic review
Authors:   Pirogov Russian National Research Medical University, Zakiev Vadim D. , Martynyuk Tamila V. ,   Pirogov Russian National Research Medical University,   Chazov National Medical Research Center for Cardiology, Kotovskaya Yulia V. ,   Pirogov Russian National Research Medical University
Published: June 2024

Relevance. Pulmonary arterial hypertension (PAH) is a rare complication of systemic lupus erythematosus (SLE). Due to the nonspecificity of symptoms and difficulties in diagnosis, the exact incidence and prevalence of PAH associated with SLE is unknown. Aim. A systematic review of studies assessing the incidence and prevalence of PAH associated with SLE. Material and methods. A systematic search was performed for studies investigating the incidence and prevalence of PAH associated with SLE published from January 1, 2000 to December 31, 2023. The search was carried out in the PubMed/MEDLINE database for English-language publications and in the RSCI database for studies in Russian according to pre-defined inclusion and exclusion criteria. Results. 53 potential publications were identified, all sources in English. 11 publications remained for further assessment after screening article titles and abstracts. After detailed analysis, 6 articles were excluded because they did not meet the inclusion and exclusion criteria. Totally, 5 studies were included in the systematic review. Three studies assessed prevalence only, one study assessed incidence only, and one study assessed both prevalence and incidence. The prevalence of PAH associated with SLE ranged from 0 to 4.2%, with 3-year and 5-year cumulative incidence rates of 0.53–1.2% and 0.77–1.8%, respectively.
Experience in the treatment of depressive disorders with vortioxetine after hysterectomy
Authors:   Dagestan State Medical University, Umahanova Zoya R. , Magomedova Teili S. ,   Dagestan State Medical University, Mamedov Ferzi S. ,   Dagestan State Medical University
Published: June 2024

Relevance. Antidepressants are widely used in clinical practice for neurological disorders. Vortioxetine refers to the latest generation of drugs, the appointment of which is appropriate for depressed patients after hysterectomy. Objective: to evaluate the effectiveness of vortioxetine in combination with menopausal hormone therapy in correcting depressive symptoms after hysterectomy. Materials and methods. 136 patients with depressive disorder after hysterectomy (average age 44.7±1.3 years) were examined and treated, who were divided into two groups. The main group consisted of 74 (54.4%) patients who were prescribed divigel with vortioxetine in combination. The control group included 62 (45.6%) patients who used only divigel. All underwent clinical and laboratory monitoring, psychological assessment on the Hamilton Depression scale (HDRS-21). Results. In the main group according to the Hamilton scale (HDRS-21), 26 (35.1%) patients showed mild depression, 48 (64.9%) moderate depression, in the control group 20 (32.2%) and 42 (67.8%) respectively. Against the background of complex therapy, a decrease in the indicators of the mental and somatic component was revealed. After a month, 16 (21.7%) patients of the main and 22 (35.4%) of the control group complained of depression, depression, a sense of self-worth, 21 (28.3%) and 27 (43.5%) of guilt, 9 (12.1%) and 11 (17.8%) slow thinking, 25 (33.8%) and 29 (46.8%), respectively, for a decrease in motor activity. Before the start of treatment, 49 (66.2%) patients of the main and 40 (64.5%) control groups complained of headache of varying intensity, 11 (14.9%) and 8 (13.0%) of pain in the lumbar region, 17 (23.0%) and 15 (24.1%), respectively, of body aches and soreness in small joints. During the first month of treatment, pain in the lumbar region decreased, followed by headaches, and soreness in the body and joints lasted longer. Conclusions. Against the background of taking an antidepressant in the examined patients, positive dynamics of the disease was noted, both in the subjective assessment of the condition and in the objective result of psychological symptoms. Vortioxetine, which has high clinical efficacy and good tolerability, can be recommended in the treatment of depression after hysterectomy.
Functional masks of neurological disorders: differential diagnosis of organic and psychogenic disorders
Authors:   State budgetary healthcare institution of the Moscow region “Kotelnikovskaya City Clinic”», Kotelniki, Russia, Davidov David R. ,   Moscow University of Industry and Finance (Synergy University), Moskvicheva Aleksandra S. ,   Moscow University of Industry and Finance (Synergy University)
Published: June 2024

Differentiation of organic and psychogenic disorders is one of the most difficult tasks of neurology and psychiatry, both because of the difficulties in determining the genesis of the condition itself, and because of their frequent comorbidity. A certain commonality of the pathogenetic nature of both disorders allows, when choosing therapeutic tactics, to rely on drugs that affect the central link in the pathophysiology of these processes – an imbalance of mediator systems. The purpose of this study was to study the efficacy and safety of Pantogam Active in patients in the complex therapy of neurological and psychiatric diseases in outpatient settings. The analysis included 120 people divided into 2 groups: group 1 took the main therapy and Pantogam Active on the recommendation of the attending physician at a daily dosage of 600–1200 mg (the average daily dosage is 900 mg), group 2 – only the main therapy. Patients were randomly assigned to groups. The duration of the study was 3 months. The effectiveness and safety were evaluated during a control examination by a specialist and based on the results of evaluation scales. The results of the study demonstrate a positive effect on both subjective feelings (well-being of patients receiving complex therapy) and changes in an objective assessment. The addition of the main therapeutic regimen with Pantogam Active is recommended for patients in order to correct concomitant symptoms that reduce the quality of life and adherence to treatment: asthenic syndrome, anxiety and depressive disorders, cognitive impairment.
Habilitation and rehabilitation of patients with traumatic brachial plexopathy involving the use of the EXAR 34 passive exoskeleton
Authors:   Volgograd State Medical University, Kurushina Olga V. , Vorobyov Alexander A. ,   Volgograd State Medical University, Volgograd, Russia; Federal Center for Support of the Development and Production of Exoprostheses,   Volgograd Medical Research Center, Andryushchenko Fedor A. ,   Federal Center for Support of the Development and Production of Exoprostheses, Nezhinsky Dmitry I. ,   Volgograd State Medical University,   Federal Center for Support of the Development and Production of Exoprostheses
Published: June 2024

Recovery after traumatic plexitis is a complex and lengthy process that requires rehabilitation measures involving the use of both conventional methods, such as drug therapy, therapeutic exercise, physical therapy, and psychological counseling, and innovative technologies, such as EXAR 34 passive upper limb exoskeleton.
Corc Tarâbîşî’nin Şâfiî’nin Hadislere Yaklaşımına Getirdiği Tenkitler ve Bu Tenkitlerin Değerlendirilmesi
Authors: Kazan Tahsin , Çakmak Şenol
Published: June 2024

Müslümanların din tasavvurunda hadisler Kur’ân’dan sonra ikinci kaynak olarak görülür. Kur’ân’a iman edenlerin zihninde bu ilahi kitap tevatür yoluyla geldiğinden sıhhati noktasında bir tereddüt bulunmamaktadır. Hadislerin ise Hz. Peygamber’e aidiyeti isnat yöntemiyle tespit edildiğinden eleştiriler daha çok bu noktada yoğunlaşmaktadır. Müslüman âlimler, hadislerin Hz. Peygamber’e aidiyet problemini çözmek için cerh ve ta‘dil ilmine başvurmuşlardır. İslâm coğrafyasında yaşayan gayri Müslim bilginler tarafından da hadislere ve İslâm düşünce ekollerinin oluşumunda önemli rolü olan âlimlere yöneltilen tenkitler bulunmaktadır. Suriyeli yazar ve mütercim olan Corc Tarâbîşî, İslâm ve İslâm’ın şekillendirdiği Arap medeniyetine dair çok sayıda eser yazmış bir bilgindir. Bu çalışmada Kur’ân İslâm’ından Hadis İslâm’ına adlı eserinde Tarâbîşî’nin Şâfiî’nin hadis anlayışına yönelttiği tenkitler ele alınmıştır. Tarâbîşî’nin eserinde Şâfiî’ye yönelttiği tenkitler doküman analizi tekniğiyle tespit edilip tasvirî yöntemle irdelenmiştir.
A necessidade da regularização fundiária prévia em áreas de potencial eólico como mecanismo de proteção dos posseiros ante o processo de expansão energética: o caso de Santa Luzia, Paraíba, Brasil
Authors: Maia Fernando Joaquim Ferreira , Basso Ana Paula , Souza Karolina Maria Fonseca de
Published: June 2024

Analisa-se a regularização fundiária prévia em áreas de potencial eólico no município de Santa Luzia-PB. Justifica-se pela necessidade de estudos que analisem a parte fundiária da instalação dos parques eólicos. A absorção dos excedentes de capital tem impactado negativamente a regularização fundiária, assim, questiona-se: Qual a importância da regularização fundiária prévia para os posseiros em áreas de potencial eólico? O objetivo é investigar se a regularização fundiária prévia pode proteger os posseiros na negociação com as empresas. O método parte dos estudos de Mariana Traldi (2022) e a metodologia da pesquisa passa pela coleta e tratamento de dados a partir da legislação, da jurisprudência, de livros e de artigos científicos relacionados ao tema, além de estudo do caso de Santa Luzia. A hipótese é que a regularização fundiária prévia pode dar mais segurança jurídica aos posseiros nas negociações com as empresas para a implantação dos aerogeradores em suas propriedades.
Reestruturação produtivo-territorial em Mato Grosso do Sul, Brasil: observações a partir da implantação da Suzano Papel e Celulose em Ribas do Rio Pardo (2021-2023)
Authors: Delcol Rafaela Fabiana Ribeiro , Heimbach Samuel da Silva
Published: June 2024

O objetivo deste trabalho é analisar o processo de reestruturação produtivo-territorial em Mato Grosso do Sul, especificamente, em Ribas do Rio Pardo, em decorrência da instalação da Suzano Papel e Celulose em 2021. Parte-se do pressuposto de que a inserção do plantio de eucalipto no estado desde 1970 tem gerado alterações substanciais no território, sobretudo nos municípios que abrigaram unidades industriais além das áreas de plantio. Os procedimentos metodológicos adotados se baseiam em revisão bibliográfica, trabalho de campo, análise de dados primários e secundários, a fim de compreender o processo de reestruturação produtivo-territorial em Ribas do Rio Pardo/MS. Os resultados indicam transformações no cenário econômico, político e demográfico da região, além de evidenciar como a cidade e o campo têm sido moldados por uma nova lógica de produção, estruturada para atender as demandas da empresa e do capital industrial.
The Acceptance of Payment Methods Through Blockchain Technology and Cryptocurrency: The Effect of Brand Image
Authors: Özcan Selami , Alazzawi Maaroof
Published: June 2024

Blockchain technology, along with cryptocurrencies like Bitcoin, Ethereum, and stablecoin represent potential advancements that could change the financial industry. Stablecoins, have established a presence could change the traditional mechanisms of global economy. Nonetheless, consumer adoption of these technologies has been slightly slow. Many aspects and gaps are still not filled in the literature about these new technologies. In this research, using the technology acceptance model (TAM) to see the factors behind the intention to use cryptocurrencies as a payment method by examining the brand image role in the intention to use cryptocurrencies and blockchain technologies for payment methods. The research has been done through an online survey, distributed between group of people with different backgrounds in Türkiye. The survey was conducted in Turkish, and all scales and measurements have been tested and approved in previous studies. The findings indicate that brand image impacts the intention to use cryptocurrencies and blockchain technology transactions. Also, the strongest relation is between attitude (A) and brand image (BI) these finding highlight the importance of brand image in driving consumer’s attitude and intention to use cryptocurrencies as payment method. Moreover, we discuss in the conclusion.
Parental, Peers and Teachers’ Factors as Correlates of Career Choice among Adekunle Ajasin University Undergraduates, Ondo State, Nigeria
Authors: Ojewola, Florence O. Ph.D
Published: June 2024

Purpose: The study investigated parental, peers and teachers’ factors as correlates of career choice among Adekunle Ajasin University undergraduates in Ondo State, Nigeria.
Materials and Methods: Correlational survey research design was adopted for this study. The population of this study consisted of all Adekunle Ajasin University undergraduates. The sample consisted 296 respondents randomly selected from eight faculties in the University. Simple random sampling technique was used to select six faculties while purposive sampling procedure was used to select fifty respondents from each of the six faculties. A total of 296 respondents were used for the study. A self- designed instrument was used to collect Information on parental, peers and teachers’ factors as correlates of career choice among AAUA students.  Four hypotheses were generated and tested at 0.05 level of significance. Regression and Pearson Product Moment Correlation were the statistical tools employed to test the hypotheses in the study.
Findings: The findings indicated that there were joint contributions of Peers’, teachers’ and parental influence on the career choice of AAUA students. The result indicated that the students of AAUA were influenced by their peers in their career choice. The influence of parents’ and teachers’ were not prominent in the career choice of AAUA students. Therefore, it is concluded that peers, parental and teachers’ factors collectively influenced the career choice of AAUA students.
Implications to Theory, Practice and Policy: It was recommended that parents and teachers need to encourage their children in their choice of career and be careful not to force any career on them.  Career guidance and counselling should be made available to the young people so as to assist them in choosing correct and proper career that they have passion for.
The Influence of Mattering and a Sense of Belonging on Students’ GPA: A Case Study of Colleges of Education in the Volti Zone, Ghana
Authors: Kolamong Clement Kantam , Fianu Sewornu Kwame , Eshun Patrick , Asare Seth , Degboe Fred Edinam , Nordzi Gifty
Published: June 2024

The quest into what influences student performance is a perennial endeavour in educational settings. Among the multitude of variables under investigation, the notions of significance and a feeling of inclusion have gained increasing attention for their potential impact on academic achievement. This research looked at the impact of mattering and sense of belonging on students’ GPA. Using case studies from Volti Zone in Ghana, and the quantitative research design, data were gathered from 522 teacher trainees utilizing validated scales. The results of the bivariate regression analysis revealed that each individual construct of mattering and sense of belonging influences students’ GPA, with mattering (β = .104; t = -.716; p = .045) and sense of belonging (β = .052; t = .065; p = .003). Similarly, the multivariate regression results revealed that both constructs combined influence students’ GPA, with mattering (β = .024; t = -.918; p = .043) and sense of belonging (β = .017; t = .578; p = .035). The research findings indicate that the levels of mattering and sense of belonging significantly correlate with teacher trainees’ GPA, with increased levels of both factors corresponding to higher academic performance. In essence, greater feelings of significance and belongingness are associated with improved GPA outcomes among teacher trainees in Ghana.
Green Features Project Management: Value Added to Residential Property
Authors: Misnan Mohd Saidin , Mohamed Sarajul Fikri , Ramly Zuhaili Mohamad , Kamaruddin Tantish , Hua Priscilla Yong Chang
Published: June 2024

Green buildings with green features are sustainable buildings and have less harmful effects on the natural environment, resource consumption and human health. Since the global warming issue has worsened and the number of housings is increasing, the role of green features in green housing has become highly important in creating a good sustainable living environment. However, to date, the level of developed green housing is still below the mainstream housing even though Green Buildings Index (GBI) has been implemented in Malaysia. The objectives of this study are to identify current green features that are applied in green housing, to quantify the construction costs of green features that are applied and to identify the factors that influence the acceptance levels of green housing. The scope of the study included collecting data from developers through five case studies of housing projects. Questionnaire and semi structured interviews and documents’ review were conducted to gather information from the respondents, of developers or architects, and 120 home buyers on green housing. The result shows that current green features that are mostly applied by housing developers are passive green features such as building orientation, window and daylight. From the perspectives of cost effectiveness and to meet the purpose of comfortable housing, developers will choose to apply passive green features. The construction cost of green feature window and daylight is the highest. The main factors that influence the acceptance level of green housing by home buyers is the comfort of green housing followed by the green housing pricing. Further, the research recommends looking into the details of the cost of savings in the long term for green features and developers’ opinions on the perception of the home buyers when it comes to factors that influence their acceptance level of green housing. It is recommended that an in-depth study be conducted on green features to study the problems and issues related to improve the green features design.
Разработка модели K-Means для выявления наиболее выгодных предложений на рынке недвижимости Москвы
Authors: Зуев М. А. , Шибаев В. М. , Баланев К. С.
Published: June 2024

В статье рассматривается применение модели кластеризации K-Means для анализа рынка недвижимости Москвы. Основное внимание уделяется сегментации рынка с целью выявления наиболее выгодных предложений. Использованные данные включают параметры стоимости, площади, близости к метро, год постройки и другие характеристики объектов недвижимости. Метод "локтя" был применен для определения оптимального числа кластеров, которое впоследствии было увеличено до восьми для более точного сегментирования. Полученные результаты показали, что кластер 0 представляет собой наиболее доступные и выгодные предложения. Модель K-Means, разработанная в ходе исследования, может быть использована покупателями для оптимизации процесса выбора жилья, снижая временные и финансовые затраты.
Anthropocene Metabolism - Natural Resources and Carbon Capture in the Age of Climate Crisis
Authors: Havsteen-Mikkelsen Asmund
Published: June 2024

This article explores the concept ‘Anthropocene metabolism’, which refers to how the metabolism of the human body has changed during The Great Acceleration of the Anthropocene with huge consequences for domesticated animals and wild nature. Furthermore, the article explores the conditions for the metabolic processes of the body and the natural resources that go into providing food for the planet's eight billion inhabitants. The infrastructure around the consumption of food is shown to have been made possible by a vast and globalised ‘Anthropocene arena’, defined by a huge dependency on fossil fuels. The article thereafter explores the climate crisis as a hybrid crisis and argues that the shift to a plant-based diet could reduce the environmental impact of our global metabolism and thereby free agricultural land for re-wilding and re-forestation, allowing for massive carbon capture. Finally, it is assessed how the reforestation of approximately 28 million square kilometres would be able to mitigate climate change.
 
Received: 15 December 2023 | Revised: 26 February 2024 | Accepted: 20 June 2024
 
Conflicts of Interest
The author declares that he has no conflicts of interest to this work.
 
Data Availability Statement
Data available on request from the corresponding author upon reasonable request.
 
Author Contribution Statement
Asmund Havsteen-Mikkelsen: Conceptualization, Methodology, Investigation, Writing - original draft, Writing - review & editing.