bluuebunny/crossref_metadata_2025 huggingface dataset:
Projeto Língua EmCena: peças teatrais como fonte para o estudo sócio-histórico da língua
Authors: Berlinck Rosane Andrade , Brandão Sílvia Maria , Barbosa Juliana Bertucci , Biazolli Caroline Carnielli , Sene Marcus Garcia
Published: February 2024

Apresentamos a proposta do projeto Língua EmCena, e exemplificamos sua aplicação a partir de um estudo sobre a mudança na morfologia verbal do Português Brasileiro em sentenças condicionais inseridas pela conjunção –se. Esse projeto propõe a construção de corpora de peças brasileiras (séculos XIX a XXI) e a caracterização do perfil social de seus personagens, utilizando categorias definidas segundo a reconstrução dos contextos sócio-históricos dos períodos analisados. Para tal, estabelecemos um diálogo interdisciplinar (com História, Sociologia, Antropologia e Teatro). Os resultados demonstram a relevância de trabalhos com peças teatrais no campo da Sociolinguística Histórica e da categorização proposta para as variáveis sociais sexo/gênero, idade, escolaridade/instrução, classe social e etnia, revelando correlações entre essas variáveis e processos de variação e mudança linguísticas.
Pengaruh Literasi Keuangan Berbasis SAK EMKM Terhadap Kinerja dan Keberlangsungan Usaha Pada UMKM di Kota Salatiga
Authors: Andreas Hans Hananto , Wibowo Alvelino Syahputra
Published: February 2024

Penelitian ini bertujuan untuk melihat pengaruh literasi keuangan terhadap kinerja dan keberlangsungan usaha pada UMKM di kota Salatiga. Literasi keuangan dapat memberikan informasi yang baik untuk meminimalkan keputusan yang salah dalam menjalankan usaha dalam mengatur kinerja dan mempertahankan keberlangsungan usaha. Penelitian menggunakan data primer dengan metode kuesioner dengan total 48 responden. Literasi keuangan berpengaruh positif terhadap kinerja usaha, literasi keuangan berpengaruh positif terhadap keberlangsungan usaha. Penelitian ini berdampak bagi UMKM, pemerintah dan masyarakat sekitar dimana UMKM yang memiliki perencanaan keuangan serta pengembangan usaha yang baik dapat meningkatkan nilai ekonomi daerah dan membuka lapangan pekerjaan.
Reflection of “O Nga: Laa” Value behind Capital Accounting Practices by Farmers
Authors: Thalib Mohamad Anwar , Suaib Rafka , Edis Edis
Published: February 2024

Purpose: This study aims to reveal capital accounting implemented by rice farmers based on local cultural values. Design/methodology/approach: This study uses an Islamic paradigm with an Islamic ethnomethodology approach. There are five data analysis stages: charity, knowledge, faith, revelation information, and courtesy.Research Findings: The study results show that farmers implement four capital accounting: capital sourced from debt, from side business income, capital used to finance agricultural needs, and capital used to share, among others. The practice of capital accounting is conditional on family (“O nga: laa”) value. It is reflected through the actions of farmers who use their crops to fulfill their personal needs and distribute rice free of charge to their neighbors. This is so the farmers’ neighbors can also feel happiness when the harvest season arrives. In the Islamic culture of the people of Gorontalo, the value of “O nga: laa” is often internalized by the elders through the expression (lumadu) “diila bo ilaato binthe wawu pale.” This expression contains the meaning of a family statement because of blood relations or family ties.Contribution/Originality/Novelty: The results of this study provide implications for the existence of the concept of capital accounting by farmers with local cultural values.

Tujuan Penelitian: Penelitian ini bertujuan untuk mengungkapkan akuntansi modal yang dipraktikkan oleh petani padi berdasarkan nilai budaya lokal.Desain / metodologi / pendekatan: Kajian ini menggunakan paradigma Islam dengan pendekatan etnometodologi Islam. Ada lima tahapan analisis data yaitu amal, ilmu, iman, informasi wahyu, dan ihsan.Temuan Penelitian: Hasil kajian menunjukkan bahwa petani menerapkan empat praktik akuntansi modal, yaitu modal yang bersumber dari hutang, dari pendapatan usaha sampingan, modal yang digunakan untuk membiayai kebutuhan pertanian, dan modal yang digunakan untuk berbagi, dengan sesama. Praktik akuntansi modal syarat dengan nilai kekeluargaan (“O nga: laa”). Hal itu tercermin dari tindakan para petani yang menggunakan hasil panennya untuk memenuhi kebutuhan pribadi dan membagikan beras secara cuma-cuma kepada tetangganya. Hal ini agar tetangga petani juga bisa merasakan kebahagiaan saat musim panen tiba. Dalam budaya Islam masyarakat Gorontalo, nilai “O nga:laa” sering diinternalisasikan oleh para tua-tua melalui ungkapan (lumadu) “diila bo ilaato binthe wawu pale” Ungkapan ini mengandung makna pernyataan kekeluargaan karena adanya hubungan darah atau ikatan keluarga.Kontribusi / Orisinalitas / Kebaruan: penelitian ini memberikan kontribusi tentang hadirnya konsep akuntansi modal oleh para petani berbasis nilai budaya lokal.
State Failure and The Sunni-Shia Conflict in Sampang Madura
Authors: Siddiq Akhmad , Imama Lely Shofa , Febriansyah Muhammad , Hisyam Muhamad Ali
Published: February 2024

This paper attempts to explain the process of conflict reconciliation within the Sunni-Shia conflict in Sampang, Madura. The research tries to analyze the process and progress of the Sunni-Shia conflict through the discourse of state failure. It will not only figure out the discourse through political or security perspective, but also tries to view the failure and the weakness of the state from the conflict-transformation and social perspective. This research aims to look at how religious identity has been played within the process of conflict reconciliation and how the state failed to solve the Shia-Sunni conflict in Sampang. In doing so, the paper explains the history of Shia in Sampang Madura, the chronology of the conflict and its escalation, and the absence of the state within the long process of reconciliation.
PENGARUH JENIS BUSI TERHADAP EMISI GAS BUANG DAN KONSUMSI BAHAN BAKAR PADA MOBIL DAIHATSU ZEBRA 1.3
Authors: Nurdin Edi , Putra Wawan Trisnadi , Winangun Kuntang
Published: February 2024

Emisi gas buang kendaraan bermotor merupakan penyumbang terbesar terjadinya pencemaran udara.Setiap jenis busi memiliki karakteristik percikan dan warna bunga api yang berbeda, begitu juga dengan nilai Emisi gas buang dan Konsumsi Bahan Bakar. Untuk membuktikannya dilakukan penelitian menggunakan variasi 3 jenis busi, Busi NGK Standar, Busi NGK Platinum, dan Busi NGK Iridium IX dengan bahan bakar premium yang dicampur dengan bioethanol. Kendaraan yang digunakan pada penelitian ini 1 unit Daihatsu zebra dengan kapasitas mesin 1300 cc. Tujuan penelitian ini untuk mengetahui nilai gas buang dan konsumsi bahan bakar yang dihasilkan, dalam penelitian ini menggunakan metode penelitian eksperimental. Teknik pengambilan data yaitu pada masing –masing busi diuji berdasarkan prosedur antara busi standar, busi platinum, dan busi iridium terhadap emisi gas buang. Putaran mesin yang digunakan 2000 rpm, 3000 rpm dan 4000 rpm selama 1 menit. Penggunaan jenis busi Iridium (BKR6EIX) pada kendaraan mobil Daihatsu Zebra 1.3 menghasilkan emisi gas buang CO, HC, dan Lambda paling rendah jika dibandingkan dengan jenis busi standart dan jenis busi platinum. Untuk emisi CO yang dihasilkan sebesar 0,33 % vol, untuk emisi HC sebesar 187,2 ppm vol, dan untuk emisi lambda sebesar 1,027 % vol. Dari hasil penelitian konsumsi bahan bakar penggunaan jenis busi Iridium (BKR6EIX) pada kendaraan mobil Daihatsu Zebra 1.3 dapat menghemat konsumsi bahan bakar sebesar 1,31% dari jenis busi Standart dan pada penggunaan jenis busi Platinum menghemat konsumsi bahan bakar sebesar 1,2% jika dibandingkan dengan jenis busi Standart. Dari hasil penelitian bisa disimpulkan bahwa pemakaian jenis busi Iridium (BKR6EIX) untuk kendaraan mobil Daihatsu zebra 1.3 lebih ramah lingkungan dan hemat bahan bakar
Prodidomus Hentz, 1847 and Zimiris Simon, 1882 on Ascension Island (Araneae: Prodidomidae)
Authors: Sherwood Danniella , Gringet Virginie , Marusik Yuri M. , Sharp Adam
Published: February 2024

A review of type material and newly collected material of the family Prodidomidae Simon, 1884 from Ascension Island is presented. Prodidomus clarki Cooke, 1964 is proposed as a junior synonym of Prodidomus rufus Hentz, 1847 syn. nov., and Prodidomus duffeyi Cooke, 1964 is deemed as a valid species but known only from a single bleached specimen, further material is needed to fully clarify its identity, The third prodidomid species on the island is confirmed as Zimiris doriae Simon, 1882.
likvärdig skola?
Authors: Wigerfelt Berit
Published: February 2024

Sweden is one of the countries which has signed and endorsed The United Nations Convention on the Rights of the Child from 1989. According to this convention, all children have the same rights irrespective of sex, race or religion. The convention is in line with Swedish education policy, which for a long time has asserted that schooling must be open to all. The Swedish curriculum stresses that all human beings are of equal value and states, amongst other things, that “education must be suited to the needs and requirements of each pupil”. However, there is reason to strongly question whether Sweden in practice lives up to these ideals and aims. During 2005, the National Agency of Education made inspections of the schools in Malmoe and, in a report from 2006, drew the conclusion that schooling in the city was characterized by large local inequalities with regard to both opportunities and results. One aim of this study is to use the representation of Malmoe´s schools given in the National Agency report to ascertain whether Malmoe is achieving the goal of giving all pupils an equal education; ultimately, I pose the question whether Malmo can live up to the UN Convention on the Rights of the Child. Another aim is to develop understanding of the school as a place of normative and regulating practices in relation to a changed and multicontextual childhood. The empirical data for this study is the said report from the National Agency of Education.
STRATEGI PEMASARAN PAKET WISATA DALAM MENINGKATKAN JUMLAH KUNJUNGAN WISATAWAN DI DESA WISATA TISTA, KERAMBITAN, TABANAN
Authors: Aldu Maria Pricilla Cahyavika , Sudana I Putu , Dewi LGLK.
Published: February 2024

Tista tourism village is one of the tourism villages located in Kerambitan District, Tabanan Regency, Bali. This village sells various tour packages and has been designated as a tourist village since 2016 but tourist visits are still relatively small. Therefore, this research was conducted to find out the marketing strategy of the Tista tourism village tour package in increasing tourist visits.The data analysis technique is internal environment using 7P Marketing Mix analysis and the external environment using market, competitor, government, technology, and economic analysis and SWOT. Data types use qualitative and quantitative data. Data sources use primary and secondary data sources. Data collection techniques using observation, interviews, documentation, literature studies, and distributing questionnaires. The data analysis technique uses descriptive qualitative. The results of the study used 18 internal indicators and 7 external indicators, then obtained 14 strengthes, 4 weaknesses, 4 opportunities, and 3 threats. Based on the results of data processing, it’s known that the total IFAS value is 3.10 and the EFAS value is 3.02 so that the position of the Tista tourism village tour package is in cell V, namely Growth Strategy/Stability Strategy with concentration through horizontal integration. A suitable strategy is a strategy that can prevent profit loss and loss of profit.
PENGARUH PROMOSI ELECTRONIC WORD OF MOUTH (E-WOM) TERHADAP KEPUTUSAN STAYCATION DI UBUD DAN CANGGU
Authors: Valineli Samantha Elana , Agus Wikanatha Sagita Putu , Kristianto Yohanes
Published: February 2024

This study aimed to determine whether E-WOM had an influence on staycation decisions in Ubud and Canggu. This study determined the sample by purposive sampling method with a total sample of 100 respondents. Data collection used a questionnaire, literature study, and documentation. The data analysis technique in this research is descriptive quantitative with validity test, reliability test, classical assumption test, linear regression analysis, t test, and coefficientdetermination test. This study used the IBM SPSS statistics 25 for Windows program to carry out research tests. The results of the analysis showed that E-WOM quality had t count 2.027 > t table 1.988 with a significance value of 0.047 > 0.05, then E-WOM quantity had t count 2.113 > t table 1.988 with a significance value of 0.037 <0.05 then Sender’s expertise variable had t count 3.447 > t table 1.988 with a significance value of 0.001 <0.05. These results showed that the variables E-WOM quality, E-WOM quantity and Sender’s expertise influence the staycation decision. The results of this study also showed that E-WOM has a significant simultaneous effect on staycation decisions in Bali with a coefficient of determination of 65%.
PENGARUH KUALITAS PELAYANAN DRIVER GRABCAR TERHADAP KEPUASAN WISATAWAN NUSANTARA DI BADUNG, BALI
Authors: Sarfina Eminilda , Sendra I Made , Sudana I Putu
Published: February 2024

GrabCar is an internet-based transportation service that can be accessed through an online application that rejuvenates users/tourists, but there are some complaints from users or tourists when using GrabCar. The purpose of this study is to determine the effect of GrabCar Driver service quality on the satisfaction of domestic tourists in Badung Regency, Bali. The operational definition of variables used in this study is X, Y and characteristics. The sampling technique uses accindental sampling with a total of 100 respondents, namely domestic tourists who have used GrabCar in Badung Regency, Bali. Data collection techniques are carried out by observation, questionnaires, interviews, literature studies, and documentation. This research is quantitative descriptive by using simple linear regression analysis as data analysis. This study uses descriptive data analysis which is processed using the SPSS 25.0 application for windows. The results of simple linear regression analysis through partial testing of the effect of variable X on Y show that the t test obtains a significant value of 0.000 <0.005, which means that the service quality variable has a positive effect on tourist satisfaction. The R square determinant coefficient value is 0.630, service quality affects domestic tourist satisfaction, while the remaining 37% is influenced by other variables such as competition variables, price variables, trust variables, for the Grab manager must improve facilities, maintain the company's image, hospitality to tourists/ passengers, and improve CHSE standards.
Determinants of Rural Development in European Union Countries and Türkiye
Authors: KARAHAN Hüseyin , HEPAKTAN Cemal Erdem
Published: February 2024

There are many variables that can affect rural development. The aim of the study is to find out what variables affect rural development in Türkiye and European Union countries. The data period used in the study was, annual data for the period 2002-2020. According to the results of the random effects model, Inflation, Rural Population, and Rural Population Increasing variables from 8 independent variables affect Rural Development. According to the results of the Generalized Estimation Equality Mass Average Test based on the Random Effects Model, population growth in Rural Areas, Population in Rural Areas and Inflation variables were statistically significant. In the study, the Granger causality test was performed to measure the causality links of the variables. It was found that there is a bidirectional causality relationship between the exports of Agricultural Raw Material and the employment rate of young people aged 15 -24 in rural areas. Results with unidirectional causality or no causal relationship were found among the remaining variables.
Algılanan Aşırı Vasıflılık ve İşten Ayrılma Niyeti İlişkisinde İşe Yabancılaşmanın Aracılık Rolü
Authors: UÇAR Zeki
Published: February 2024

Bu araştırmada işgörenler tarafından algılanan aşırı vasıflılığın işten ayrılma niyeti üzerindeki etkisinde işe yabancılaşmanın aracılık rolünün incelenmesi amaçlanmıştır. Niceliksel olarak tasarlanan bu araştırma için örneklem Bitlis ilinde faaliyette bulunan kamu ve özel banka çalışanları ve Türkiye Serbest Muhasebeci ve Mali müşavirler ve Yeminli Mali Müşavirler Odaları Birliği’ne (TÜRMOB) bağlı serbest muhasebe ve mali müşavirlik çalışanlarından seçilmiştir. İlgili örnekleme ulaşmak ve araştırmaya veri sağlamak amacıyla kolayda ve kartopu örnekleme yöntemleri kullanılmıştır. Hazırlanan anket formları katılımcıların bir kısmına online olarak diğer kısmına ise elden dağıtılmıştır. Araştırma ölçeklerinin güvenilirlik ve geçerliliklerinin tespiti amacıyla ölçek maddeleri üzerinde güvenilirlik, birleşim ve ayrışım geçerliliğine ilişkin testler ve faktör analizleri gerçekleştirilmiştir. Son olarak yapısal eşitlik modellemesi üzerinden araştırma modeli test edilmiştir. Analizler sonucunda algılanan aşırı vasıflılığın alt boyutlarından olan basitlik algısının işten ayrılma niyeti üzerindeki etkisinde işe yabancılaşmanın aracılık etkisi bulgulanırken, diğer alt boyutlar olan yakıştırmama ve vasıflılık algısı boyutları üzerinde aracılık etkisi gözlenememiştir. Literatür incelemelerine dayalı olarak bu üç değişkeni bir arada inceleyen ve yine araştırma modelinde ortaya konan aracılık etkisini araştıran herhangi bir çalışmaya rastlanmamıştır. Bu literatürde bir boşluk yaratmaktadır ve dolayısıyla da bu çalışma ile bu boşluğun doldurulması amaçlanmaktadır.
Organization of the educational process in the post-blockade time in Leningrad
Authors: Prishchepa Aleksandr Sergeevich , Khazov Vladimir Konstantinovich
Published: February 2024

This article is devoted to the organization of the educational process in post-war Leningrad. This process is described as one of the factors of the rapid and sustainable recovery of urban industry in the second half of the 1940s. The blockade lasted for a long four years. The result of it was a massive destruction of the city. However, the main damage that Leningrad suffered and which significantly slowed down the process of its restoration was the mass death of people. The city is faced with an acute shortage of workers, primarily high-class professionals. The blockade caused huge damage to the material part of Leningrad universities. The elimination of this damage, carried out largely by the work of their employees, students and teachers, is one of the Great Pages of history. It was the combination of pedagogical and scientific thought that allowed many post-war profiles of industrial enterprises to appear. Students and young scientists actively contributed to the resumption of production of almost the entire range of pre-war products, as well as the development of new types of products, modern machines, machine tools, devices. As a result of the set of measures analyzed in this article, the Leningrad industry in terms of gross output reached the pre-war level in the late 1940s, and was able to exceed it by 1950.
Proverbs and sayings in modern Chinese textbooks for studying Russian as a foreign language as tools of creating the image of Russia
Authors: Barsukova Elena Aleksandrovna , Zhang Yan
Published: February 2024

In Russian as a foreign language textbooks, proverbs and sayings dedicated to Russian culture are often encountered. These fixed expressions enrich the foreign students’ associations with Russia and its people as well as comprehensively draw a truthful and vivid image of Russian culture, and enhance the students’ interest in studying the Russian language. In the present research, proverbs and sayings are considered not only as a culturological phenomenon but also as a means of shaping an image of Russia in Russian as a foreign language textbooks. The object of the study is the Russian proverbs and sayings in modern Chinese textbooks of Russian as a foreign language. The article examines the role of the Russian proverbs and sayings as the tools for creating the image of Russia in modern Chinese textbooks of Russian as a foreign language. The material of the paper consists of proverbs and sayings in the textbooks "Russian Language in Universities" published in China from 2008 to 2014. Using continuous sampling method, we have identified more than 250 Russian proverbs and sayings. The methodology of the work combines elements of comparative and content analysis of the source data. The scientific originality of the study involves identification of the structure of Russia’s image represented by the proverbs and sayings under consideration. The article identifies and analyzes the following components of the image of Russia created by proverbs: natural, historical images, images of spiritual culture and everyday life. Proverbs and sayings are a phenomenon of human existence, fragments and treasures of popular wisdom. They reflect the natural image, character, mentality, worldview of the people who created them, their traditions, customs, and history, etc. Considering both linguistic and extralinguistic factors, the author concludes that in modern Chinese textbooks of Russian as a foreign language, Russian proverbs and sayings have become effective and constructive means of stimulating rich associations about Russia among students, and they shape a typical natural image, a rich image of spiritual culture, multifaceted everyday life, and a comprehensive historical image of Russia.
Reports of Swedish diplomats on the events of the First World War (based on the decryption of diplomatic correspondence)
Authors: Kostrikov Sergei Petrovich , Kostrikov Stanislav Sergeevich , Kazarova Nina Akopovna
Published: February 2024

The subject of the study is the decrypted telegrams of Swedish diplomatic missions sent to the Minister of Foreign Affairs of the Swedish Kingdom K. Wallenberg, intercepted by the special services of the General Staff of the Russian Army at the end of 1915-1916. Sweden, while remaining a formally neutral power, nevertheless not only closely followed the events on the fronts of the First World War, but also conducted active trade and provided transit services to both Germany and Russia, deriving huge economic benefits from this situation. The documents of this period mainly cover the events in the Balkans, where the allied forces of the Entente tried to deploy the so-called Salonika (Macedonian) front to help the Serbian army and to divert enemy forces from other fronts. Based on the methods of historicism and systematic research, the reports of diplomats who informed their leadership about the events around Thessaloniki, about the situation and actions of the allied forces and the troops of the Central Powers, about the further intentions of the opposing forces, about the fate of Serbia and Montenegro, express assessments and opinions on specific issues and the prospects for the development of the war. Since there were supporters of both the Entente and the Austro-German bloc in the Swedish elite, the following conclusions can be drawn from the documents under consideration. They allow us to assess the range of issues of the most interest to Swedish diplomats and the Swedish government, as well as the degree of their awareness, the quality of information sources and the level of understanding of the content of the events taking place. These documents are very important for clarifying Sweden's position during the First World War. Since there were supporters of both the Entente and the Austro-German bloc in the Swedish elite, it can be understood from the documents under consideration that during this period it became increasingly obvious to Swedish diplomats that despite all the difficulties, including in the Balkans, the preponderance of the Entente countries was more likely. Most of the analyzed archival materials are being introduced into scientific circulation for the first time.
Aprender-haciendo: la microgénesis de ecologías de aprendizaje en la niñez maya tsotsil
Authors: de León Lourdes
Published: February 2024

El estudio documenta procesos de aprendizaje generados por la iniciativa de niños/as mayas tsotsiles del sureste mexicano en actividades valoradas culturalmente. Examina el adiestramiento mediante la exploración y la práctica (aprender-haciendo) de un niño (tres, cuatro y siete años de edad) en diversas actividades (por ejemplo, carpintería, cargar objetos con mecapal, tejido) desde el lente de una etnografía longitudinal, la videoetnografía y el microanálisis interaccional. Toma como eje la ecología del aprendizaje situado, definida como un sistema socioecológico que emerge de las acciones de los participantes, la comunicación multimodal y la apropiación de destrezas pertinentes a actividades de relevancia cultural. Se argumenta que la microetnografía de la ecología de aprendizaje ofrece las herramientas analíticas de la microgénesis del aprendizaje en el marco de la teoría de la actividad de Vygotsky (1978).
Abordamiento etnográfico de las ecologías de aprendizaje infantil en dos enclaves rurales de Argentina
Authors: Remorini Carolina
Published: February 2024

Este trabajo se propone contribuir al estudio interdisciplinario de las “ecologías del aprendizaje” a partir de datos provenientes de investigaciones etnográficas en dos enclaves rurales e indígenas de Argentina. El estudio se basa en la observación y descripción de las actividades diarias de niños/as en el marco de las rutinas domésticas. Se analizan cinco secuencias de actividad cuyos protagonistas son niños/as de entre 18 y 26 meses de edad, que nos permiten identificar y caracterizar dos casos de “ecologías de aprendizaje”. Nos enfocamos en la iniciativa y autonomía de los niños para crear entornos que facilitan su aprendizaje y ejercitación de habilidades de valor cultural, así como en las actitudes y roles de otros actores en la interacción con los/as niños/as en dichos entornos. Los resultados ponen de relieve el valor de la descripción de microcontextos de actividad como base para la comparación de entornos ecológicos diversos y, así, la contrastación de conceptos y modelos teóricos sobre el aprendizaje y la agencia infantil.
Aprender con agencia e iniciativa: conocimientos de salud y enfermedad de los niños mayas yucatecos
Authors: Jiménez-Balam Deira , Alcalá Lucía
Published: February 2024

El objetivo de este artículo es describir el papel de la agencia y la iniciativa en el proceso de aprendizaje de los niños mayas yucatecos sobre la salud y la enfermedad. Con base en el paradigma de Learning by Observing and Pitching In (LOPI), se explora la manera en que los niños estructuran ecologías de aprendizaje en las que construyen sus conocimientos medicinales. Empleamos técnicas etnográficas, observaciones y un cuestionario para entrevistar a 22 niños mayas de 7 a 12 años de una comunidad maya del sur de México. Los resultados indican que todos los niños aprendieron el uso y la preparación de múltiples plantas medicinales, además de que monitorean sus propias acciones para mantener su salud; así generan sus propias ecologías de aprendizaje. La iniciativa y la motivación propias para ayudar a los demás a atender su salud tienen un papel fundamental en el proceso de aprendizaje, y, asimismo, su agencia es crucial y respetada.
Association of single nucleotide polymorphism Lys198Asn of the endothelin-1 gene with it’s concentration in the serum of multiple myeloma patients
Authors: Мордвинова Е.В. , Сустретов А.С. , Миронова Т.П. , Давыдкин И.Л. , Наумова К.В. , Степанова Т.Ю.
Published: February 2024

Множественная миелома (ММ) – гематологическое злокачественное новообразование, характеризующееся клональной пролиферацией патологических плазмацитов. Пациенты с ММ имеют риск сердечно-сосудистых заболеваний (ССЗ) на исходном уровне 54–74%. Важную роль в развитии и/или прогрессировании ССЗ играет эндотелиальная дисфункция (ЭД), в основе которой лежит дисбаланс, в частности, между синтезом и секрецией вазоконстрикторов и вазодилататоров. В связи с предиктивно-превентивной направленностью медицины актуальным стало изучение генетической предрасположенности к развитию ЭД. Нами была изучена связь генетических вариантов EDN1 (rs5370) с концентрацией эндотелина-1 (ЭТ-1) в сыворотке крови у пациентов с впервые выявленной ММ до начала противоопухолевой терапии. В результате исследования было выявлено следующее распределение генетических вариантов в исследуемой группе: доля гомозигот по варианту дикого типа составила 13,64%, по минорному варианту – 29,55%, доля гетерозигот – 56,82%. В контрольной группе распределение было следующим: 40,00%, 24,44% и 35,56%, соответственно. У больных ММ наблюдалась более высокая концентрация ЭТ-1 в сыворотке при сравнении с пациентами без ММ.

Multiple myeloma (MM) is a hematological malignancy characterized by clonal proliferation of abnormal plasma cells. Patients with MM have a baseline cardiovascular disease (CVD) risk of 54–74%. An important role in the development and/or progression of CVD is played by endothelial dysfunction (ED), which is based on an imbalance, in particular, between the synthesis and secretion of vasoconstrictors and vasodilators. In connection with the predictive and preventive focus of medicine, it has become relevant to study the genetic predisposition to the development of ED. We have studied the association of genetic variants of endothelin-1 gene (rs5370) with the concentration of endothelin-1 (ET-1) in the blood serum of patients with newly diagnosed MM before the start of anticancer therapy. As a result of the study, the following distribution of genetic variants in the study group was revealed: the wild variant was 13.64%, the minor variant was 29.55%, and the heterozygous variant was 56.82%. While in the control group it was as follows: 40.00%, 24.44% and 35.56%, respectively. Patients with MM had higher serum ET-1 concentrations when compared with patients without MM.
ANRIL gene polymorphism and susceptibility to atherosclerosis
Authors: Тимофеева С.В. , Шерчкова Т.А. , Шкурат Т.П.
Published: February 2024

Проведен метаанализ для оценки связи между полиморфизмом ANRIL rs2383207 и предрасположенностью к атеросклерозу. Для выявления подходящих исследований был проведен систематический поиск литературы в базах данных Google Scholar и PubMed. Всего для мета анализа было отобрано 12 исследований. Ассоциацию оценивали по статистическому отношению шансов (ОШ) с 95% доверительным интервалом (ДИ). Программное обеспечение RevMan (Cochrane Collaboration, 5.3. Копенгаген) использовали для мета анализа. При объединении исследуемых популяций в одну выборку показано, что ген ANRIL был связан с риском атеросклероза. Дальнейший стратифицированный анализ по этническому признаку показал, что ген ANRIL был связан с предрасположенностью к атеросклерозу как у азиатов, так и у европеоидов. Наши результаты показывают, что ANRIL может служить генетическим биомаркером атеросклероза. Для подтверждения наблюдаемой связи потребуются дальнейшие исследования.

We conducted this meta-analysis to estimate associations between polymorphisms of ANRIL rs2383207 and susceptibility to atherosclerosis. A systematic literature research of Google Scholar and PubMed was performed to identify eligible studies. Overall, 12 studies were included for meta-analyses. The association was assessed by statistical odds ratio (OR) with 95% confidence interval (CI). RevMan software (Cochrane Collaboration, 5.3. Copenhagen) was used for the meta-analysis. Pooled overall analyses showed that ANRIL was associated with risk of atherosclerosis in the whole population. Further analyses by ethnicity revealed that ANRIL was associated with susceptibility to atherosclerosis in Asians and Caucasions. Our results suggest that ANRIL, might serve as genetic biomarkers of atherosclerosis. Further studies will be required to confirm the observed association.
Clinical case of the maple syrup urine disease in the neonate
Authors: Бугун О.В. , Мартынович Н.Н. , Богоносова Г.П. , Астахова Т.А. , Рычкова Л.В. , Барыкова Д.М. , Кузнецова С.Н. , Осипова Е.Г. , Дорофеева Т.Ю. , Михельсоне Ю.В.
Published: February 2024

Наследственные болезни обмена веществ представляют собой обширную группу заболеваний, в совокупности затрагивающих до 2-3% популяции. Такая частота, а также возможность проведения эффективной терапии ряда нозологических форм, создают предпосылки к активному изучению метаболических заболеваний. Для ряда наследственных болезней обмена веществ характерны острое и ранее начало в первые дни или месяцы жизни ребенка и агрессивное течение с высокой вероятностью развития летального исхода. Такое течение болезни требует быстрой разработки стратегии обследования и лечения пациента. В группу болезней с ранним и острым началом входит лейциноз или болезнь с запахом кленового сиропа мочи, который относится к нарушениям обмена аминокислот (аминоацидопатиям). Учитывая низкую распространенность каждой нозологической формы собрать большую выборку пациентов с конкретным заболеванием очень сложно. Поэтому описание даже отдельно взятого случая представляет клинический интерес. В данной статье приведены краткие данные о распространенности, патогенезе, клинической картине и лечении болезни с запахом кленового сиропа мочи. Также представлен клинический случай пациента с классическим течением лейциноза из собственной практики.

Inborn errors of metabolism are an extensive group of congenital diseases, collectively affecting up to 2-3 % of the population. A number of hereditary metabolic diseases is characterised by an acute and earlier beginning in the first days or months of a child’s life and an aggressive course with a high probability of mortality. This course of the disease requires a rapid development of a strategy for the examination and treatment of the patient. The article presents a clinical example of a child with maple syrup urine disease. Given the rare frequency, it is very difficult to collect and analyze a large group of patients with leucinosis. Therefore, the description of even a single case is of clinical interest and is useful for highlighting the medical audience.
“A Spanish version of EastEnders”: a reception study of a telenovela subtitled using MT
Authors: Guerberof-Arenas Ana , Moorkens Joss , Orrego-Carmona David
Published: February 2024

This article presents the results of three AVT reception experiments with over 200 English-speaking participants who watched a 20-minute clip of a Mexican telenovela in three different translation modalities: human-translated (HT), post-edited (PT) and machine-translated (MT). Participants answered a questionnaire on narrative engagement, enjoyment, and translation reception of the subtitles. The results show that viewers have a higher engagement with PE than HT, but there is only a statistically significant difference when PE is compared to MT. When it comes to enjoyment, the differences are more pronounced, and viewers enjoy MT significantly less than PE and HT. Finally, in translation reception, the gap is even more pronounced between MT vs. PE and HT. However, the high HTER scores demonstrate that a substantial amount of edits are necessary to render the automatic MT subtitles publishable. It is not clear that results would be comparable were subtitlers not given sufficient time or remuneration for the post-editing task.
A Fast and Efficient MN-Approach for Reactivity of Natural Product Exploration in Plant Extract: Application to Diterpene Esters from Euphorbia dendroides
Authors: Nothias-Esposito Mélissa , Roussi Fanny , Paolini Julien , Litaudon Marc , Desrat Sandy
Published: February 2024

Natural products represent a rich source of bioactive compounds covering a large chemical space. Even if challenging, this diversity can be extended by applying chemical modifications. However, these studies require generally multigram amounts of isolated natural products and face frequent testing failures. To overcome this limitation, we propose a rapid and efficient approach that uses molecular networking (MN) to visualize new chemical diversity generated by simple chemical modifications of natural extract. Moreover, the strategy deployed enables the most appropriate reagents to be defined quickly upstream a reaction on a pure compound, in order to maximize chemical diversity. This methodology was applied to the latex extract of Euphorbia dendroides to follow the reactivity towards a series of acids and Lewis acids of three class of diterpene esters identified in this species: jatrophane, terracinolide, and phorbol. Through the molecular networking interpretation, in aim to illustrate our approach, two Lewis acids were selected for chemical modification on previously isolated jatrophane esters. Three rearranged compounds (3−5) were obtained when exposed to BF3.OEt2, showing that the most appropriate reagents can be selected by MN interpretation.
Self-assembled nanoscale upconversion POP composite for hypoxia relieving and enhanced chemotherapy in hepatocellular carcinoma
Authors: Mukherjee Poulami , Guha Subhabrata , Ghosh Antara , Kar Korak , Das Gaurav , Sahu Sumanta Kumar
Published: February 2024

Uncontrolled proliferations and altered metabolism of cancer cells result an imbalance of nutrients as well as oxygen supply and persuade hypoxia. This hypoxia in turn activates the transcription gene HIF-1α which eventually upregulates the efflux transporter P-gp and induce MDR. Thus, hypoxia leads to resistance towards conventional therapy methods. Therefore, the fabrication of a nanoscale porous system enriched with upconversion nanoparticle to target the cancer cells, evade hypoxia and enhanced anticancer therapy is the key goal of this chapter. Herein, the upconversion nanoparticles are embedded with the nanoscale POP and further conjugated with targeting moiety and also with catalase molecule. The nanoscale POP embedded with UCNPs are generated in room temperature. Targeting ligand lactobionic acid is attached after polymer coating which effectively targets liver cancer cells. Then catalase is grafted effectively produces oxygen. The endogenously generated oxygen alleviates the hypoxia of the liver cancer cells. The drug and catalase-loaded composite exhibits more cytotoxicity in case of hypoxic liver cells than the normal cells by overcoming hypoxia and downregulating the hypoxia inducible factors.
Communication efficiency enhanced federated learning derived from quantum reinforcement learning for retrosynthesis
Authors: Hu Junjie , Li Xiangyu , Liu Dan-Dan , Wang Shiyi , Fang Yingying , Wu Peng , Yang Guang
Published: February 2024

The combination of parametric quantum circuits and density matrix coding can significantly reduce the number of parameters in artificial neural networks. The reduction in the number of model parameters helps to improve the commu- nication efficiency when training deep learning models under federated learning architectures. In this study, we showcase the enhanced communication efficiency achieved in federated learning by utilizing quantum neural networks in the context of the molecular inverse synthesis task within reinforcement learning. Specifically, we consider the federated learning task on the reinforcement learning-based retrosynthesis. we adopted the USPTO-50k chemical reaction dataset. the MLP and quantum neural network are used as the agent of the reinforcement learning algorithm, respectively. Enhancements in communica- tion efficiency stem from the capacity of encoded quantum states within quantum neural networks to effectively represent data. All instances are additionally situated within the framework of ligand molecules associated with Tau proteins.
Stoichiometric and Catalytic Insights into the Lithium Nickelate Me-diated C–F Bond Alkynylation of Fluoroarenes
Authors: Borys Andryj M , Vedani Luca , Hevia Eva
Published: February 2024

Low-valent nickelates have recently been shown to be key intermediates that facilitate challenging cross-coupling reac-tions under mild conditions. Expanding the synthetic poten-tial of these heterobimetallic complexes, herein we report the ability of tri-lithium nickelate Li3(TMEDA)3Ni(C≡C–Ph)3 to promote the stoichiometric C–F activation of aryl fluorides furnishing novel mixed Li/Ni(0) or Li/Ni(II) species depend-ing on the substrate and conditions employed. These stoichi-ometric insights can be upgraded to catalytic regimes to enable the atom-efficient alkynylation of aryl fluorides and polyfluoroarenes with lithium acetylides and Ni(COD)2 as pre-catalyst, and operates without the need for external lig-ands, Cu co-catalysts or additives.
Who is my Neighbour? Theological Education in the Global Village of the 21st Century (Responses)
Authors: Finch Karen , Huntly Alyson
Published: February 2024

Chukwuemeka Anthony Atansi’s keynote address offered a series of reflections on how the Igbo theological anthropology of the neighbour can enrich theological education in diverse contexts such as Montreal. The Igbo theological anthropology of the neighbour offers a relational understanding of the neighbour, a relationality which comprises a crucial component of Karen Finch’s response, one which argues that good pastoral education in today’s polarized world strongly resembles good ecumenical formation. For Finch, ecumenical formation is about relationality and the dialogues that this relationality provokes, and she argues that, when approached with openness and transparency, such dialogues can be truly generative for pastoral education.

Alyson Huntly’s response offers a series of reflections about the state of theological education in Quebec, reflections which also highlight relationality, or, more precisely, the need for Western institutions, hitherto predominantly white, to re-evaluate and re-envision how they relate to – and thereby dialogue with and learn from –  the “Others” who now represent a majority demographic in Quebec’s theological colleges, many of whom come from the Global South or formerly colonized nations. This, she argues, represents the path to renewal for theological education in twenty-first century Quebec.
A Systematic Review of Solubility Enhancement Techniques Used for BCS Class II & IV
Authors: Dhoble Pavankumar , Tekade Bharat , Bodke Vishal , Kale Mohan
Published: February 2024

Because of their low solubility, pharmaceutical researchers encounter tremendous difficulties in creating sustainable and more soluble drugs (BCS class II). About 40% of oral dosage forms have formulation and development problems due to water insolubility. The rate of dissolving, absorption, distribution, and excretion of an active medicinal substance is determined by its solubility parameters. Based on their solubility, drugs are divided into four kinds under the BCS categorization system. BCS Class II and Class IV drugs have problems with solubility. Increasing both the bioavailability and the solubility of poorly soluble medications can be accomplished in several ways. Some techniques—like solid dispersion, solid complexation, liquisolid, hydrotropy, sonocrystallization, and self-emulsifying techniques—are commonly used for solubility augmentation. Until an orally active medication dissolves in the lining of the stomach and/or intestinal fluids, it cannot pass through the GI tract membrane and enter the bloodstream. Therefore, a medication that is insoluble in water will typically exhibit limited absorption by dissolution, and a medication that is weakly permeabilized via membranes would typically exhibit limited absorption through permeation. Consequently, improving the oral bioavailability of active substances is the focus of two areas of pharmaceutical research: (i) accelerating the process of dissolution and solubility of drugs that are poorly soluble in water, and (ii) accelerating the permeability of poorly permeable drugs.
Synthesis, Investigation of Anticancer and Antioxidant Activity of Certain 2,4-Diaryl Substituted Benzodiazepine and Benzothiazepines Derived From Vanillin
Authors: S. Kittur Bharatesh , N. Masuti Sadanand , R. Deshpande Shreenivas , B. Kittur Bhumika , B. Biradar Sharanbasav , Srinivas Y. , S. Chilakantmath Guruprasad
Published: February 2024

In search of new more effective and selective anticancer agents a series of 2-3-methoxy-4-hydroxy phenyl-4-p-substituted phenyl1-H-15-benzodiazepines 2a-j and 2-3-methoxy-4-hydroxy phenyl-4-P-substituted phenyl 23-dihydro-15-benzothiazepines 3a-j were synthesized from the corresponding chalcone intermediates derived from the reaction between vanillin and substituted acetophenones by condensing with o-phenylenediamine and o-aminothiophenol respectively. Completion of reaction was monitored by TLC compounds were purified by recrystallization and structures were confirmed by UV IR 1HNMR 13CNMR and Mass spectral data. Title compounds were screened for anticancer activity against A549 Lung carcinoma cell line by MTT and antioxidant activity by DPPH radical scavenging assays. 5-Flurouracil and ascorbic acid were used as standard drugs. Among the compounds evaluated in the series compound 3i emerged showing highly active anticancer and antioxidant activity with a IC50 value of 19.20microM and 0.023microM respectively. The compounds that exhibited excellent to good antioxidant activity did not exhibit good anticancer activity. Thus some of the title compounds were found to possess good anticancer and antioxidant activity warranting further research.nbsp
Synthesis and Antimicrobial Activity of 3-(2-(Substituted 1,3,4-Thiadiazol-2-Ylamino)Acetyl) -4-Hydroxy-1-Methyl/Phenylquinolin-2(1H)-Ones
Authors: Nandeshwarappa BP , Manjunatha SK , Ramesh DK , Suchitra M , Sadashiv SO
Published: February 2024

Background The design of new agents active against resistant organism is of critical importance. The current antimicrobial chemotherapy still suffers from two major limitations. The first is the lack of selectivity of conventional antimicrobial agents which in turn brings about unwanted side effects. The second is acquisitions by the microorganism of multi drug resistance.Objective To synthesize a series of quinoline-2-one linked thiadiazole derivatives and to asses in vitro antimicrobial activity.Method The derivatives of quinoline-2-one linked thiadiazole were synthesized purified and characterized on the basis of physiochemical and spectral studies. The synthesized compounds were subjected for in vitro antimicrobial activity by cup-plate agar diffusion.Results Among the eight synthesized novel compounds three compounds 4b 4c and 4f shows promising antibacterial activity as compared to Ciprofloxacin 100 microgml however most of them 4b 4c 4e and 4f showed potent antifungal activity as compared to Fluconazole 100 microgml.Conclusion Despite continued efforts to discover improved antimicrobial agents there has been little success towards discover of antimicrobial agents. The compounds having fluoro substitution at 4th amp 24-dichloro positions showed satisfactory antibacterial and antifungal activity.nbsp