bluuebunny/crossref_metadata_2025 huggingface dataset:
Response Rates of Extra-Nodal Diffuse Large B Cell Lymphoma to anti CD19-CAR T Cells - a Real Word Retrospective Multi-Center Study
Authors: Beyar-Katz Ofrat , Perry Chava , Bar-On Yael , Grisariu Sigal , Yehudai-Ofir Dana , Luttwak Efrat , Avni Batia , Zuckerman Tsila , Sdayoor Inbal , Stepensky Polina , Ringelstein-Harlev Shimrit , Libster Diana , Sharvit Liat , Amit Odelia , Greenbaum Uri , Gold Ronit , Herishanu Yair , Benyamini Noam , Avivi Irit , Ram Ron
Published: November 2022

Chimeric antigen receptor T-cells (CAR-T) are widely used for the treatment of relapsed/refractory Diffuse large B cell lymphoma (DLBCL). The data for CAR-T cell therapy in patients with extra-nodal(EN) lymphoma is restricted. We included 126 consecutive patients with DLBCL treated with commercially available CAR-T cells (tisagenlecleucel, n=100, 79.4% and axicabtagene ciloleucel, n=26, 20.6%). At lymphodepletion , 72/126(57%) had EN disease, 42/126(33%) patients had nodal disease (ND)-only and 12/126(10%) showed no disease assessed by PET-CT. There were no significant differences in CAR-T related toxicities and in the median PFS between EN patients and ND [10.76(95% CI: 7.8-13.6) vs 14.1 (95% CI:10-18.1) months, p =0.126)]. Similarly, median OS was not significantly different [15.36 (95% CI 12.5-18.2) vs. 18.4 (95% CI 14.8-22.1) months , p =0.100]. Subgroup analysis according to the number of EN involved sites showed that median PFS and OS were significantly higher in patients with ≤ 2 EN sites [12.3 months (95% CI 9-15.5)] vs 4.28 months (95% CI 0.6-7.9), p=0.010] compared to patients with ≥3 EN sites, respectively[16.5 months (95% CI 13.4-19.6) vs 8.7 months (95% CI 4.6-12.8), p=0.05]. In multivariate cox regression analysis, increased number sites of EN disease and high LDH at lymphodepletion negatively impacted PFS (p=0.021 and <0.001, respectively), while sex, type of product administered, age and performance status did not predict PFS and OS. Of note, all the patients with involvement of gastrointestinal tract (n= 9), urinary tract (n= 9), or pharynx (n= 3) at lymphodepletion progressed or had an early relapse.
In conclusions, both short and long term outcomes were similar in patients with EN and patients with ND at lymphodepletion, however patients with specific sites of EN disease may demonstrate grim prognosis.
Methane Converted in Methanol and Energy Using a PdCu/TiO 2 in a Polymer Electrolyte Reactor – Fuel Cell Type
Authors: Godoi Camila M. , Coelho Jessica F. , Maia Victoria A. , Gomes Paulo V. R. , Zambiazi Priscilla J. , Neto Almir O. , Souza Rodrigo F.B.
Published: November 2022

Thus, the catalytic conversion of greenhouse gases such as methane into liquid fuels facilitated by the input of electrical energy presents an immense opportunity for new energy sources. This work presents a series of catalysts based on Pd-doped with Cu supported on TiO2 to evaluate the electrocatalytic activity in a fuel cell reactor for the conversion of methane to methanol and energy co-generation. The nanostructures of the catalytic materials were analyzed by TEM and by XRD. To monitor the oxidation products obtained from the methane oxidation, such as methanol and formate were employed the FTIR and Raman spectroscopy was used to qualify the methanol formation, and the HPLC was used to quantify this product. Thus, the use of TiO2 support shows promising results for the conversion of methane to methanol. In addition, the presence of Pd favors the formation of alcohol in addition to increasing the electrical power of FC.
Research on VLF Method Forecasting of Satellite Navigation and Communication Environment
Authors: Li Bei , Niu Youtian , Zhao Xiukun , Wang Zhe , Yang Sai , Zheng Zhiyuan
Published: November 2022

Solar flares are the most violent outbursts that occur in localized regions of the solar atmosphere. They emit large amounts of X-rays and energetic particles. X-rays reaching the earth at the speed of light will disrupt the calm ionospheric environment, causing sudden ionospheric disturbance (SID), which will make the very low frequency (VLF) signal to sudden phase anomaly (SPA), lead to the positioning error of satellite navigation system and interfere with satellite communication. Energetic particles will arrive near the satellite orbit in 1–3 days, causing direct damage to the satellite. They may also cause geomagnetic storms after reaching the Earth. In this paper, we mainly study to monitor solar activity and calculate solar flare class through the phase variation of VLF signal by combining the theory of VLF waveguide mode in order to forecast the environment of satellite navigation and communication. In addition, it can also predict energetic particles and geomagnetic storms 1–3 days in advance according to the time and class of flare outbreak, so that the protective measures for satellite to operate safely could be taken in advance.
Polymorphisms and expression of MMPs-TIMPs genes associated with cerebral ischemic stroke in young patients with sickle cell anemia
Authors: Ó Kleyton Palmeira do , Freire Ana Karla da Silva , de Nóbrega Debora Nascimento , Souza Roberta dos Santos , Farias Isabela Cristina Cordeiro , Belmont Taciana Furtado de Mendonça , Silva Andreia Soares da , Arcanjo Gabriela da Silva , Araujo Aderson da Silva , Anjos Ana Cláudia Mendonça dos , de Araujo Antônio Roberto Lucena , Bezerra Marcos André Cavalcanti , de Moura Patricia Muniz Mendes Freire , Cavalcanti Maria do Socorro Mendonça , Vasconcelos Luydson Richardson Silva
Published: November 2022

Background
Sickle cell anemia (SCA) is a genetic disease with great clinical heterogeneity and few viable strategies for treatment; hydroxyurea (HU) is the only widely used drug. Thus, the study of single nucleotide polymorphisms (SNPs) and the gene expression of MMPs 1, 2, 9, 7 and TIMPs 1 and 2, which are involved in the regulation of extracellular matrix, inflammation, and neuropathies, may provide further insights into the pathophysiology of the disease and elucidate biomarkers and molecules as potential therapeutic targets for patients with SCA.
Methods and Results
We evaluated 251 young individuals with SCA from northeastern Brazil. The groups were divided according to vaso-occlusive crisis (VOC) and cerebrovascular disease (CVD), compared to control individuals. SNP detection and gene expression assays were performed by real-time PCR, TaqMan system®. Both the expression levels of MMP1 gene, and the SNP MMP1 -1607 1G/2G were associated with the risk of cerebral IS, and the expression of MMP1 was also associated with a higher frequency of VOC/year. Expression levels of MMP7, TIMP1, and TIMP2 were increased in patients conditioned to IS. The SNP 372T>C (rs4898) TIMP1 T alleles were more frequent in patients with >5 VOC events/year. The SNP rs17576 of MMP9 showed differences in gene expression levels; it was increased in the genotypes AG, and AG+GG.
Conclusion
The findings of this study, the SNPs, and expression provide initial support for understanding the role of MMPs-TIMPs in the pathophysiology of SCA in young patients.
Development of Seismic Microzonation Maps for Low to Moderate Seismicity Regions Using Microtremor Observation Data
Authors: Lee Jian Yee , Chow Tze Liang , Chong Fui Lip , Cheah Yi Ben , Lau Tze Liang
Published: November 2022

Microzonation in low to moderate seismicity regions is not extensively used due to a lack of attention given. Accordingly, the structures are not designed for earthquake loading. However, these countries are susceptible to earthquake threat caused by local and far field earthquakes. The far field effect of earthquakes from neighbouring countries can be felt in Penang Island, Malaysia, which is contrary to the perception that Malaysia is seismic free. This hazard serves as a reminder of the importance of seismic study, particularly in the light of the local geological conditions. This work presents the ground structure of Penang Island for seismic microzonation map development using a simpler and affordable method for low to moderate seismicity regions. Moreover, this study applies microtremor single point and array observation methods to estimate the ground structure of Penang Island. The estimated ground structures are validated using the available borelog data and the results show good agreement. The developed microzonation maps show that Penang Island has a ground structure with a predominant frequency ranging from 1.45 Hz to 7.4 Hz andVs,30in the range of 168 m/s to 468 m/s. The northeast (Georgetown) and western (Balik Pulau) regions of Penang Island show a low frequency andVs,30value, indicating that these areas have a soft ground structure. The study demonstrates a simple and affordable method that can be adopted by low to moderate seismicity countries to develop seismic microzonation maps.
Peripheral blood T cell modulation by omalizumab in chronic urticaria patients
Authors: López Cristina , Depreux Nathalie , Bielsa Isabel , Roger Albert , Quirant-Sánchez Bibiana , Basagaña Maria , Jurgens Yanina , Padró Clara , Miquel Sira , Martínez-Cáceres Eva , Teniente-Serra Aina
Published: November 2022

Background: Chronic spontaneous urticaria (CSU) is a highly prevalent and difficult to manage disease. One of the main treatments used in CSU is the monoclonal antibody omalizumab, which effect on the immune system is still unknown. The understanding of the mechanism of action of this biological drug along with the identification of potential biomarkers in these patients would be useful to a more personalized management of the disease.
Objective: To identify potential biomarkers of response in peripheral blood of patients with CSU under omalizumab treatment.
Methods: We analyzed 71 patients with CSU, 33 under omalizumab and 38 under non-immunomodulatory drugs and 50 healthy donors as controls. We collected demographic and analytical data such as inflammation markers, atopy and immunological parameters and recorded the Urticaria Activity Score 7 (UAS 7) questionnaire on the control of the disease. Flow cytometry immunophenotyping of T-cell subpopulations, indirect Basophil Activation Test (BAT) to detect anti-IgE antibodies and anti-thyroid antibodies were studied.
Results: A reduction in the UAS 7 questionnaire has been seen before and after omalizumab treatment. Regarding the immune profile, we observed a higher percentage of type Th1 and Th2 cell subpopulations in the treated group with omalizumab compared with the others control groups. Furthermore, an increasing trend on Th17 and Th1 lymphocytes, and some activated T lymphocyte populations such as CD4+HLA-DR+CD38+ was observed on patients under omalizumab treatment.
Conclusions: The findings from this study demonstrate the involvement of omalizumab on adaptive immunity in the pathogenesis of chronic urticaria.
Comparison between the NUTRIC score and modified NUTRIC score to predict hospital mortality in cardiac surgery patients: A retrospective study
Authors: Xu Jing , Luo Dandong , Chi Ruibin , Deng Jia , Fang Heng , Wu Qingrui , Xu Wang , Huang Jianyang , Chen Chunbo
Published: November 2022

Background
Nutritional status is essential for patients undergoing cardiac surgery (CS), and malnutrition is an independent risk factor for postoperative adverse outcomes. The Nutrition Risk in the Critically Ill (NUTRIC) and modified NUTRIC (mNUTRIC) scores are nutritional risk assessment tools specifically for patients in the intensive care unit (ICU). The objective of this study was to validate and compare the accuracy of the NUTRIC score and the mNUTRIC score in predicting hospital mortality in CS patients.
Methods
This retrospective study screened adult CS patients under cardiopulmonary bypass in the ICU of a tertiary university affiliated hospital in China from June 2020 to August 2022. The demographic data, laboratory variables, clinical outcomes and hospital mortality of these patients were recorded, and all data were compared according to the NUTRIC score and the mNUTRIC score criteria for high and low nutritional risk. The area under the receiver operating characteristic curve (AUC-ROC) was used to compare the predictive performance of these two nutrition scores for hospital mortality.
Results
A total of 259 eligible patients were finally screened for statistical analysis; 57 patients had high NUTRIC scores, and 82 patients had high mNUTRIC scores. In both scores, patients in the high nutritional risk group had a higher rate of renal replacement therapy, longer duration of mechanical ventilation and ICU stay, and higher hospital mortality than those in the low nutritional risk group (p < 0.001). The AUC-ROC of the NUTRIC score and the mNUTRIC score for predicting hospital mortality were 0.833 (95% CI: 0.754–0.911) and 0.827 (95% CI: 0.751–0.902), respectively. There was no significant difference in ROC curves between the two scores (p = 0.532).
Conclusions
Both the NUTRIC and mNUTRIC scores showed good predictive performance for hospital mortality in CS patients, and the NUTRIC score was not superior to the mNUTRIC score.
Pattern and determinants of overweight and obesity among adolescents
Authors: Chukwuemeka Uchechukwu Martha , Donatus Chiemezie Victor , Fabunmi Ayodeji Ayodele
Published: November 2022

Purpose Obesity is one of the major factors implicated in raising morbidity and mortality in adults as well as adolescents and children. Obesity is increasing worldwide and there is evidence that this increase has been faster among the developing countries. Thus, the need to determine the pattern and determinants of overweight and obesity among adolescents. Methods This was a cross-sectional study involving 400 adolescents aged 14.38 ± 2.11years from randomly selected secondary schools. Questionnaire, weight and height metre was used to collect data. Descriptive statistics of mean ± standard deviation, frequency counts and percentage were used to summarize participants’ variables. Inferential statistics of Pearson’s correlation, independent samples t-test, Chi-square and binary logistic regression were used in hypotheses testing with 0.05 alpha levels. Result Mean of Body mass index(BMI) and daily physical activity(PA) in the last one week were 23.14 ± 3.49kg/m2and 1.84 ± 0.37 respectively with a point prevalence of 0.2(20 per 100 adolescents). There was a significant difference in BMI pattern and PA (with t-value − 3.94 and 5.31) between adolescents from public and private schools. Activity of daily living related-PA was found to have a significant association with BMI (P-value = 0.001, r = -0.17) and patterns of overweight and obesity among secondary school students (χ2 = 44.61, p < 0.001). Four predictors (PA during school recreation period, weight, height, and School type), together classified students who were likely to be overweight/obese with variance Nagelkerke R2 = 93.3%. The total prediction success is 91.8%, with 99.3% and 92.6% of those not overweight/obese and those that were correctly classified respectively. Conclusion This study highlights PA during school recreation period, weight, height, and School types as determinants of overweight/obesity in adolescents and also high prevalence of overweight and obesity.
Title: Cohort profile update: Tehran Cardiometabolic Genetic Study, a path toward precision medicine
Authors: Daneshpour Maryam S , Akbarzadeh Mahdi , Lanjanian Hossein , Sedaghati-khayat Bahar , Guity Kamran , Masjoudi Sajedeh , Zahedi Asieh Sadat , Moazzam-Jazi Maryam , Bonab Leila Najd Hassan , Shalbafan Bita , Asgarian Sara , Farhood Goodarz Koli , Javanrooh Niloofar , Zarkesh Maryam , Riahi Parisa , Moghaddas Mohammad Reza , Dehkordi Parvaneh Arbab , Ahmadi Azar Delbarpour , Hosseini Firoozeh , Farahani Sara Jalali , Hadaegh Farzad , Mirmiarn Parvin , Tehrani Fahimeh Ramezani , Ghanbarian Arash , Pasand Mohammad Sadegh Fallah Mahboob , Amiri Parisa , Valizadeh Majid , Hosseipanah Farhad , Tohidi Maryam , Ghasemi Asghar , Vakili Azita Zadeh , Alamdari Shahram , Khalili Davood , Momenan Amirabbas , Barzin Maryam , Zeinali Sirous , Hedayati Mehdi , Azizi Fereidoun
Published: November 2022

The Tehran Cardiometabolic Genetic Study (TCGS) is a large population-based cohort study with periodic follow-ups, which created a comprehensive database of 20,367 participants born between 1911-2015 selected from 4 different longitudinal, ongoing, and family-based studies. The study aims to identify the potential targets for prevention and intervention for non-communicable diseases in mid-life and late life. The study focuses on cardiovascular, endocrine, metabolic abnormalities, cancers, and some inherited diseases. Since 2017, the cohort expanded the information by coding all health-related complications (hospitalization outcomes and self-reports) based on ICD11 coding and confirming the consanguineous marriage with genetic markers. This article presents an update on the rationale and design of the study. We also present a summary of our findings and our goals toward precision medicine.
Continuous Dyeing of Cellulose Electrospun Nanofibrous Mat with Synthetic Indigo Dyes
Authors: Khatri Awais , Ali Shamshad , Javeed Alishba
Published: November 2022

In our study, cellulose electrospun nanofibrous mats (ENMs) were dyed with synthetic indigo dyes by continuous method. We have used the industrial scale dyeing procedure (pre-wetting, dyeing and washing-off steps). The effect of pH, concentration of sodium hydrosulphite, dye bath temperature and concentration of indigo dyes on the color yield (K/S) were optimized. Excellent K/S of dyed cellulose ENMs were achieved (reached to 13) with good colorfastness properties. For comparison, aniline-free synthetic indigo dyes were applied on the cellulose ENMs. The dyeing effluent was measured for pH, TDS and COD results. Considerable ecological merits have been found for dyeing effluent of aniline-free synthetic indigo dyes in comparison to the synthetic indigo dyes. Furthermore, the dyed samples were characterized by SEM analysis, ATR-FTIR spectroscopy.
Effect of presentation rate on auditory processing in Rett Syndrome: ERP study
Authors: Kostanian Daria , Rebreikina Anna , Nekrashevich Maxim , Sharaev Maxim , Voinova Victoria , Sysoeva Olga
Published: November 2022

Rett Syndrome (RS) is a rare neurodevelopmeтtal disorder characterized by mutations in theMECP2gene. Patients with RS have severe motor abnormalities and are often unable to walk, use hands and speak. The preservation of perceptual and cognitive functions is hard to assess, while clinicians and care-givers point out that these patients need more time to process information than typically developing peers. Here we examine neurophysiological correlates of auditory processing in RS as a function of presentation rate. From previous literature we knew that auditory event-related potential (ERP) is increased with prolongation of interstimulus interval (ISI). We presented a repetitive stimulus (1000Hz) at three different ISI of 900 ms, 1800 ms, and 3600 ms in children with RS and their typical development peers (TD) aged 2.5–16 years while recording 28-channels electroencephalogram, EEG. The amplitude of N1 and P2 components of event-related potential (ERP) was smaller at ISI 900 than at longer ISIs in both groups, pointing out that the basic mechanism of adaptation in the auditory system is preserved in Rett Syndrome. At the same time the latency of these components was significantly delayed in the RS than in TD. Moreover, late components (P2 and N2) were drastically reduced in Rett Syndrome irrespective of the ISI, suggesting a severely affected mechanism of integration of upcoming sensory input with memory. Based on these ERP measures it was possible to differentiate RS from TD with great accuracy (0.922 ± 0.047), being maximal with shortest ISI, supporting its implication as potential output measures in clinical trials as well as pointing to the diminishing of the neurophysiological differences between RS and TD with slowing down the presentation rate.
Energy and Performance Centric Resource Allocation Framework in Virtual Machine Consolidation using Reinforcement Learning Approach
Authors: Brahmam Madala Guru , R Vijay Anand
Published: November 2022

Virtual machines are deployed to ease the performance, management overhead and access regularities of applications on cloud platforms. Virtual machines are often susceptible to overloading burdens, delays and other hurdles during server consolidation and migration processes. In order to regulate the energy dissipation, monitor the overloading and under loading issues, dynamic consolidation processes are introduced to distribute loads across virtual machines substantially. Consolidation process demands additional computations and resources to reallocate the services from one virtual machine to another, subjected to adherence of Service Level Agreements. The proposed methodology advocates the implementation of a novel architecture for consolidating virtual machines and thus balance the energy and performance parameters. Overall resource requirements, Performance to Power Ratio (PPR) are primary factors in design of proposed Dynamic Weightage algorithm, including the clustering approach with respect to reinforcement learning techniques. Cluster of optimal virtual machines are formed, resources are allocated based on optimal energy and performance expectations. Resource requests from virtual machines are derived into a matching relationship factor to represent the respective hosts with PPR considerations. These estimations also deliver the overall workload incurred during virtual machine consolidation. It is observed that the performance throughout the cluster is maintained to be a nominal with minimal trade-off to energy. The architecture is implemented over an offline platform, which are distributed environments, enabling scalability and improved efficiency of the entire system. The system is validated on CloudSim simulator with datasets retrieved from PlanetLab. From the results obtained, it is noted that energy conservation has yielded up to 47%, with promising quality of service parameters. Results are compared with other state of art algorithms for distributed architectures and heterogeneous environments to prove the efficiency of the system.
Relationship between monocular form deprivation amblyopia and activity-regulated cytoskeleton-associated in visual cortex of kittens
Authors: Fan Haobo , Wang Ying , Zou Yunchun , Song Weiqi , Chen Siyu , Tang Xiuping , Xie Juan
Published: November 2022

Purpose
Exploring the role of activity-regulated cytoskeleton-associated (Arc) in visual cortex in visual development, and studying its expression changes in amblyopia kittens.
Methods
Fifteen 3-week-old kittens were randomly selected from the deprivation group and the control group, and raised in the natural environment. Black opaque covering cloth was used to cover the right eye of deprived kittens. Pattern visual evoked potentials (PVEP) was detected at the 3rd, 4th, 6th and 8th weeks of age, and 5 kittens were randomly selected from each group and euthanized after each detection. The Arc expression both at mRNA and protein levels was assessed using in situ hybridization and immunohistochemistry analyses. Apoptosis of visual cortex cells in 8-week-old kittens was detected by TUNEL.
Results
With the increase of age, the expression of Arc gene in visual cortex of both the deprivation group and the control group showed an upward trend, but the upward trend of the control group was more obvious. At the age of 8 weeks, the expression of Arc protein (P < 0.05) and mRNA (P < 0.05) in visual cortex of deprived kittens was lower than that of control kittens. Moreover, the number of apoptosis in visual cortex of deprivation group was higher than that of control group (P < 0.05). Correlation analysis shows that the expression of Arc gene was negatively correlated with the apoptosis level of visual cortex neurons.
Conclusions
The expression of Arc is associated with monocular form deprivation amblyopia and affects the apoptosis of visual cortex cells.
Vibrio cholerae O1 associated with recent endemic cholera shows temporal changes in serotype, genotype, and drug-resistance patterns in Bangladesh
Authors: Jubyda Fatema Tuz , Nahar Kazi Sumaita , Barman Indrajeet , Johura Fatema-Tuz , Islam Mohammad Tarequl , Sultana Marzia , Ullah Wali , Tasnim Jarin , Biswas Sahitya Ranjan , George Christine Marie , Camilli Andrew , Ahmed Niyaz , Ross Allen G. , Clemens John D. , Alam Munirul
Published: November 2022

Background
Despite the advancement in our understanding of cholera and its etiological agent, V. cholerae, the prevention and treatment of the disease are often hindered due to rapid changes in drug response pattern, serotype, and the major genomic islands namely, the cholera toxin phage, and related genetic characteristics. In the present study, V. cholerae (n = 172) associated with endemic cholera in Dhaka during the years 2015–2021 were analyzed for major phenotypic and genetic characteristics, including drug resistance patterns.
Results
Results revealed that the V. cholerae strains belonged to serogroup O1 biotype El Tor carrying El Tor -specific genes rtxC, tcpA El Tor, and hlyA El Tor, but possessed classical-biotype cholera toxin. Serotypes of V. cholerae strains differed temporally in predominance with Inaba during 2015–2017, and again in 2020–2021, while Ogawa was the predominant serotype in 2018–2019. Also, ctxB1 was predominant in V. cholerae associated with cholera during 2015–2017, while ctxB7 was predominant in 2018, and in the subsequent years, as observed until 2021. V. cholerae strains differed in their antibiotic resistance pattern with a majority (97%) being multi-drug resistant (MDR) and belonging to eight sub-groups. Notably, one of these MDR strains was resistant to eleven of the eighteen antibiotics tested, with resistance to fourth-generation cephalosporin (cefepime), and aztreonam. This extreme drug resistant (XDR) strain carried resistance-related genes namely, extended-spectrum β-lactamases (ESBL), blaOXA-1 and blaPER-3.
Conclusion
The observed temporal switching of serotypes, as well as the ctxB genotype, and the emergence of MDR/XDR V. cholerae and their association with endemic cholera in Dhaka underscore the need for routine monitoring of the pathogen for proper patient management.
Human-elephant conflict: Identifying factors behind retaliatory killings of the National Heritage animal of India in terms of electrocution in a shared landscape
Authors: Ghosh Soumyajit , Das Rana , Das Dipankar , Nandy Subrata , Das Tulsi , Sonker Gaurav , Dash Suraj Kumar
Published: November 2022

Human–elephant conflict (HEC), because of its dynamic attributes, is a persistent problem across the distributional range of elephants in Asia and Africa, crippling elephant conservation and human development. Hence, a robust understanding of the issue became fundamental before initiating conservation initiatives. In this context, we investigated 25 retaliatory killings (by electrocution) cases of elephants (Elephas maximus) and assessed local's attitudes (209) in a shared landscape of India. Quantitative analysis was conducted to analyse electrocution trends, whereas binomial logistic regression was for local attitudes. Adults and sub-adult elephants were primarily victimised irrespective of their sex, particularly in the conflict hotspot areas during major cropping seasons. Despite the prevalence of human-elephant conflicts, most respondents (60%) had a positive attitude towards elephants. Concomitantly 54% were disappointed with forest officials, indicating that human-human conflict, rather than HEC, might play a significant role in impeding the conservation of endangered species in the shared landscape.
D-xylose accelerated death of pentose metabolizing Saccharomyces cerevisiae
Authors: Nijland Jeroen G. , Zhang Xiaohuan , Driessen Arnold J.M.
Published: November 2022

Rapid and effective consumption of D-xylose by Saccharomyces cerevisiae is essential for cost-efficient cellulosic bioethanol production. Hence, heterologous D-xylose metabolic pathways have been introduced into S. cerevisiae. An effective solution is based on a xylose isomerase in combination with the overexpression of the xylulose kinase (Xks1) and all genes of the nonreductive branch of the pentose phosphate pathway. Although this strain is capable of consuming D-xylose, growth inhibition occurs at higher D-xylose concentrations, even abolishing growth completely at 8% D-xylose. The decreased growth rates are accompanied by significantly decreased ATP levels. A key ATP-utilizing step in D-xylose metabolism is the phosphorylation of D-xylulose by Xks1. Replacement of the constitutive promoter of XKS1 by the galactose tunable promoter Pgal10 allowed the controlled expression of this gene over a broad range. By decreasing the expression levels of XKS1, growth at high D-xylose concentrations could be restored concomitantly with increased ATP levels and high rates of xylose metabolism. These data show that in fermentations with high D-xylose concentrations, too high levels of Xks1 cause a major drain on the cellular ATP levels thereby reducing the growth rate, ultimately causing substrate accelerated death. Hence, expression levels of XKS1 in S. cerevisiae needs to be tailored for the specific growth conditions and robust D-xylose metabolism.
Impact of pupil size upon the quality of vision in patients implanted with an implantable collamer lens (ICL V4c): A pilot study
Authors: Zhang Qing , Huang He , Wu Yi , Qin Guanghao , Li Liangzhe , Chen Jiayan , Che Huixin , Yao Tao , Yan Chunhong , Xu Ling , Moore Jonathan E , He Wei , Yu Sile , Pazo Emmanuel Eric , He Xingru
Published: November 2022

Objective: This study aimed to assess the influence of pupil size on subjective visual quality in subjects with implanted collamer lenses (ICLs).
Methods: This retrospective study assessed eyes implanted with ICL (V4c) and categorized them into incremental groups according to pupil size. Preoperative and postoperative photopic and mesopic pupil size, uncorrected distance visual acuity (UDVA), and quality of vision (QoV) questionnaire score were assessed and compared.
Results: Post-operatively at 3-months the mean QoV score for day and night was 9.34 ± 0.76 and 8.58 ± 1.29 respectively. The mean mesopic pupil size (MPS) and mean photopic pupil size (PPS) was 6.59 ± 0.79 mm and 4.61 ± 0.74 mm respectively. PPS negatively correlated with “QoV day” (Rs = -0.413, P=0.001), positively correlated with “haloes” (Rs = 0.568*, P<0.001) and "blurred vision" (Rs = 0.243, P = 0.04) respectively. MPS negatively correlated with “QoV night” (Rs = -0.426, P=0.001), positively correlated with "haloes" (Rs = 0.624*, P < 0.001), "starburst" (Rs = 0.233, P=0.046) and "difficulty focusing" (Rs = 0.27, P = 0.025) respectively.
Conclusion: The findings of this study suggest that increasing pupil size has a negative correlation on the subjective visual quality (QoV) for day and night scores. Smaller pupil size had better QoV night scores suggesting further investigation is needed.
UHPLC-HRMS-based Metabolomic and Lipidomic Characterization of Glioma cells in Response to Anlotinib
Authors: shi yingying , Li Zhuolun , Du Qiuzheng , Li Wenxi , Liu Jiyun , Jia Qingquan , Xue Lianping , Zhang Xiaojian , Sun Zhi
Published: November 2022

Anlotinib, as a promising oral small-molecule antitumor drug, its role in glioma has been only reported in a small number of case reports. Therefore, anlotinib has been considered as a promising candidate in glioma. The aim of this study was to investigate the metabolic network of C6 cells after exposure to anlotinib and to identify anti-glioma mechanism from the perspective of metabolic reprogramming. Firstly, CCK8 method was used to evaluate the effects of anlotinib on cell proliferation and apoptosis. Secondly, ultra-high performance liquid chromatography-high resolution mass spectrometry (UHPLC-HRMS)-based metabolomic and lipidomic were developed to characterize the metabolite and lipid changes in cell and cell culture medium (CCM) caused by anlotinib in the treatment of glioma. As a result, anlotinib had concentration-dependent inhibitory effect with the concentration range. In total, twenty-four and twenty-three disturbed metabolites in cell and CCM responsible for the intervention effect of anlotinib were screened and annotated using UHPLC-HRMS. Altogether, seventeen differential lipids in cell were identified between anlotinib exposure and untreated groups. Metabolic pathways, including amino acid metabolism, energy metabolism, ceramide metabolism, and glycerophospholipid metabolism, were modulated by anlotinib in glioma cell. Overall, anlotinib has an effective treatment against the development and progression of glioma, and these remarkable pathways can generate the key molecular events in cells treated with anlotinib. Understanding metabolic reprogramming and studying the mechanism of metabolic changes is expected to provide a new strategy for the treatment of glioma.
A two-step approach-machine learning, variational autoencoder, and weighted gene co-expression network analysis identify key signature genes and pathways implicated in active visceral leishmaniasis
Authors: Verma Ram Nayan , Subbarao Naidu , Singh Gajendra Pratap
Published: November 2022

Leishmania donovani, a kinetoplastid parasite causingleishmaniasis, is an opportunistic parasitic pathogen that affects immunocompromised individuals and is a common cause ofKala-azar. Specific parasite molecules can be delivered into host epithelial cells and may act as effector molecules for intracellular parasite development. So, there is a need to develop new approaches to understanding the interaction between the host and the pathogen. In our study, we built a weighted gene co-expression network using differentially expressed genes obtained through analysis of leishmaniasis-infected patients. Our goal was to identify key signature genes and pathways associated with visceral leishmaniasis infection by network biology analysis which can identify the most influential genes in the gene co-expression interaction network. We identified five prominent genes, IFNG, SC5D, LSM1, CMC2, and SAR1B, with higher interamodular connectivity, as the key signature genes. A deep neural network model- variational autoencoder was utilized to create new features, and a support vector machine validated the key signature genes. These key signature genes are involved in various biological processes like cytokine-cytokine receptor interaction, TGF-beta signaling pathway, antigen processing and presentation, IL-17 signaling pathway, Th1 and Th2 cell differentiation, and T-cell receptor signaling pathway. Besides, we also identified 04 significant miRNAs targeted with key signature genes, includinghsa-miR-340-5p, hsa-miR-325-3p, hsa-miR-182-5p, hsa-miR-1271-5p/hsa-miR-96-5p. Further, analysis of the differentially expressed genes revealed that many critical cellular responses were triggered by visceral leishmaniasis infection, including immune responses and inflammatory and cell apoptosis. We get FDA-approved anti-inflammatory agentsEmapalumabandMethylprednisoloneas a re-proposed drug for leishmaniasis cure. Our study can enhance the understanding of the molecular pathogenesis of visceral leishmaniasis infection and have implications for the plan and execution of mRNA expression tools to support early diagnostics and treatment of visceral leishmaniasis infection.
FACTORS THAT INFLUENCE COVID-19 PATIENTS TO CHOOSE HERBAL MEDICINES
Authors:   Beaconhouse Yamsaard Huahin, Satriwithaya School, Naresuan University Secondary Demonstration School, Udonpittayanukoon School., Khosabordee Palida , Inkheaw Wisanlaya ,   Beaconhouse Yamsaard Huahin, Satriwithaya School, Naresuan University Secondary Demonstration School, Udonpittayanukoon School., Khamsuk Siritan ,   Beaconhouse Yamsaard Huahin, Satriwithaya School, Naresuan University Secondary Demonstration School, Udonpittayanukoon School., Saksangawong Varanthorn ,   Beaconhouse Yamsaard Huahin, Satriwithaya School, Naresuan University Secondary Demonstration School, Udonpittayanukoon School.
Published: November 2022

This research paper aims to study the factors that drive Covid-19 patients to take herbal supplements to find out the reasons behind the consumption of herbal supplements as the first choice of medicine. Researchers conducted the research via online interviews and online questionnaires with 30 participants who were Covid-19 patients. Factors that resulted in Covid-19 patients choosing to take herbal medicine are divided into three areas: the efficacy of herbs, properties of herbs, and access to herbal products. It was done by analyzing the data using the number of respondents. The results showed that most respondents were female (18 people), followed by 12 males. The majority of respondents were 18-35 years old, numbering 13 people, followed by the age range of 36-55 years, amounting to 10 people. Most respondents were at the bachelors degree level (17 people), followed by ten people with qualifications lower than a bachelors degree. Most respondents had an average monthly income of fewer than 10,000 baht (15 people), followed by 10,001 â€“ 30,000 baht (12 people). Regarding the properties of herbal medicines, 25 respondents commented that they have healing properties of the side effects of Covid-19. In addition, all respondents agreed that herbal medicines are reliable and safe. Regarding price, 19 respondents stated that herbal medicines were reasonably priced, while 11 indicated their prices were just acceptable. Lastly, 23 patients responded that they received medicinal advice from doctors to use herbal medicines.
A DESCRIPTIVE STUDY TO ASSESS THE KNOWLEDGE REGARDING GESTATIONAL DIABETES MELLITUS AMONG ANTENATAL WOMEN ATTENDING ANTENATAL O.P.D IN A SELECTED HOSPITAL OF DELHI WITH A VIEW TO DISSEMINATE INFORMATION THROUGH PAMPHLETS
Authors:   Professor, St. Stephens Hospital College of Nursing, Tiz Hazari, Delhi-110054., P. Joseph Sheeba , Varghese Varsha ,   Assistant Professor, St. Stephens Hospital College of Nursing, Tiz Hazari, Delhi-110054., a Deepika ,   Registered Nurse, Tirath Ram Shah Hospital, Delhi., Karakoti Drishti ,   Registered Nurse, CK Birla Hospital, Delhi., Joshi Navita ,   Registered Nurse, Dr. RML Hospital, Delhi., Kapuria Nitika ,   Registered Nurse, B.L. Kapoor Hospital, Delhi., a Sita ,   Registered Nurse., Bhardwaj Varshi ,   Registered Nurse.
Published: November 2022

A descriptive study was conducted to assess the knowledge regarding Gestational Diabetes Mellitus among antenatal women attending antenatal O.P.D. in a selected hospital of Delhi with a view to disseminate information through pamphlets. A sample of 100 antenatal women, was selected using purposive sampling technique. A structured knowledge questionnaire was administered to assess the knowledge regarding Gestational Diabetes Mellitus. The data analysis and interpretation was done using descriptive and inferential statistics. Most of the antenatal women attending ANC OPD of the selected Hospital had good knowledge regarding Gestational Diabetes Mellitus. A pamphlet on Gestational Diabetes Mellitus was developed and disseminated among antenatal women.
ODS 5 IGUALDAD DE GENERO EN LA ADQUISICION DE COMPETENCIAS TECNOLOGICAS Y EMPODERAR A LAS MUJERES
Authors:   Ph in Administration Sciences, Academic Researcher, Faculty of Administration and Finance, Autonomous University of Campeche., Monserrat Llanes Chiquini Charlotte , Alberto Perez Canul Carlos ,   Ph in Administration Sciences, Academic Researcher, Faculty of Administration and Finance, Autonomous University of Campeche., C. Llanes Chiquini Gerardina ,   Masters in accounting, Academic Researcher, Faculty of Administration and Finance, Autonomous University of Campeche., Dzib Cambranis Josue ,   Master in Higher Education, Academic Researcher, Faculty of Political Science, Autonomous University of Campeche., Vargas Toledo Miguel ,   Ph in Strategic Planning and Technology Management. Academic Researcher, Faculty of Administration and Finance, Autonomous University of Campeche., Guillermo Chuc Giselle ,   Ph in Administrative Management, Academic Researcher, Faculty of Administration and Finance, Autonomous University of Campeche., Concepcion Mex Alvarez Diana ,   Master in Pedagogy. Academic Researcher, Faculty of Engineering, Autonomous University of Campeche.
Published: November 2022

This current work shows the experience that was gotten in the education from a point of view in gender quality about the developing of the Certification Program in Computer working skills, according to the syllabus called Innovacion del ModeloEducativoInstitucional, IMEI (in English, Innovation of Institutional Educative Model) that is taught it in Universidad Autonoma de Campeche. Those skills are considered as basic skills for taking resolutions in responsible, knowledgeable and autonomous ways, which are based on respect and dignity of the human beings. All of them, because of expecting to value the plurality of identities and the living ways for the exercising of the responsible and tolerant citizenship to prevent the violence. This is a description research that expects to determine the context and educational factors, which works in the acquisition of those technological skills. The final results show the students are achiving successfully with that action program, encouraging the gender quality, developing, progress and comfort of the educative community and the society.
THROMBOEMBOLIC DISEASE DURING TUBERCULOSIS: A SERIES OF 47 CASES
Authors:   Pneumo-Phtisiology Department, Moulay Youssef Hospital, UniversityMohammed V, Rabat, Morocco, postal code: 12000., Charaf Hanane , Aharmim Mohammed ,   Pneumo-Phtisiology Department, Moulay Youssef Hospital, UniversityMohammed V, Rabat, Morocco, postal code: 12000., El Khamlichi Najoua ,   Pneumo-Phtisiology Department, Moulay Youssef Hospital, UniversityMohammed V, Rabat, Morocco, postal code: 12000., Soualhi Mouna ,   Pneumo-Phtisiology Department, Moulay Youssef Hospital, UniversityMohammed V, Rabat, Morocco, postal code: 12000., Zahraoui Rachida ,   Pneumo-Phtisiology Department, Moulay Youssef Hospital, UniversityMohammed V, Rabat, Morocco, postal code: 12000., Marc Karima ,   Pneumo-Phtisiology Department, Moulay Youssef Hospital, UniversityMohammed V, Rabat, Morocco, postal code: 12000., Benamor Jouda ,   Pneumo-Phtisiology Department, Moulay Youssef Hospital, UniversityMohammed V, Rabat, Morocco, postal code: 12000., Eddine Bourkadi Jamal ,   Pneumo-Phtisiology Department, Moulay Youssef Hospital, UniversityMohammed V, Rabat, Morocco, postal code: 12000.
Published: November 2022

Tuberculosis (TB) is considered a risk factor for thromboembolic venous disease (VTE). The prevalence of this association ranges from 0.6% to 10%. This work aims to analyze the epidemiological and clinical aspects and the therapeutic management of VTE during tuberculosis and discuss the diagnostic and especially therapeutic particularities of this association.
MOBILE SERVICE DESK: CREATING A MOBILE SERVICE DESK APPLICATION TO OPEN CALLS IN THE IT INDUSTRY IN A BEVERAGE COMPANY
Authors: De Paula Vieiralves Gabriel , Carla Silva Rayssa , Mark Lobo De Oliveira Jean , Mary Moreira De Melo Aline
Published: November 2022

In thismobile service desk application was made a system that consists of having an approach to perform the other calls, in which later will be passed to the professional who will provide the service aiming at gratification and resolution of the problem in question of the user who requested the call. This issue that is being passed to be resolved may have its completion in the IT support itself as well, because depending on the level of support being provided the support itself can effect therealization of the problem based on your expertise and experience.
Organocatalyzed-Aerobic Oxidation of Arylboronic Acids toward the Synthesis
of Phenolic Derivatives
Authors: Singh Laimujam Sidartha , Banerjee Sourav , Saha Indranil , Malakar Chandi Charan
Published: November 2022

An effective organocatalyzed ipso-hydroxylation of arylboronic acids for the preparation
of phenol derivatives has been demonstrated. The elucidated phenomenon relies on the catalytic
performance of 3-nitropyridine under the influence of sub-stoichiometric quantities of KOtBu
employing aerobic conditions in DMSO solvent. This method excludes the excess usage of oxidizing
agents and bases by providing a user-friendly synthetic tool for the preparation of phenols. It
was acclaimed that the 3-nitropyridine acts as an oxygen transferring agent from in situ generated
hydrogen peroxide to boronic acid derivatives to furnish the desired molecules. The required hydrogen
peroxide was in situ generated from aerial oxygen by the KOtBu-mediated single electron
transfer process. The described process is applicable to a variety of arylboronic acids for the preparation
of phenols in good yields with considerable resistance of functional moiety.
The Risk and The Course of Cancer Among People with Severe Mental Illness
Authors: Grassi Luigi , McFarland Daniel , Riba Michelle
Published: November 2022

The paucity of data regarding patients with Serious Mental Illness (SMI) and cancer is alarming given the fact that people with SMI, especially schizophrenia, bipolar disorders and severe depressive disorders, have in general poorer access to physical health care and higher morbidity and mortality because of physical illnesses. The aims of this review were to examine the current evidence from existing literature on the risk of developing cancer and its course among people with SMI. Equivocal results emerge regarding the risk of developing some kind of cancer among people with SMI, with contrasting data on a possible higher, similar or lower risk in comparison with the general population. In contrast, a series of studies have pointed out that patients with SMI who develop cancer are less likely to receive standard levels of cancer care, both in terms of screening, diagnosis and treatment. Also, the mortality for cancer has been confirmed to be higher than the general population. A global sensitization about these problems is mandatory in an era in which community psychiatry has been developed in all countries and that policies of prevention, treatment, follow up, and palliative care should regard all the segments of the population, including people with SMI, through an interdisciplinary approach.
Ameliorating Effects of Virgin Coconut Oil (VCO) on Nicotine
Dependence and Quality of Life in Smokers
Authors: Anggadiredja Kusnandar , Amalia Lia , Haq Fahmy Ahsanul
Published: November 2022

Background:

Safer and effective alternatives to manage nicotine dependence are still
required. Preliminary studies have shown the potential of virgin coconut oil (VCO) to be used in
dependence treatment.

Objective:

To assess the VCO effect administered for 14 days on nicotine dependence and quality of life.

Methods:

Forty smoking subjects participated in an open-label, single-center, pre/post-intervention
study, and were required to take 15 ml VCO twice daily for 14 days. They were evaluated with the
Fagerstrom Test for Nicotine Dependence (FTND) for nicotine dependence intensity and EuroQolvisual
analogue scales (EQ VAS) for quality of life.

Results:

The VCO regimen improved FTND (0.53 points decrease, p<0.05) and EQ-VAS (5.85 points
increase p<0.01) scores. Adverse events were all mild.

Conclusion:

Results of the present study suggest that VCO has the potential to be a safe and effective
adjunct therapy for the management of nicotine dependence.