bluuebunny/crossref_metadata_2025 huggingface dataset:
Learning scalable and efficient communication policies for multi-robot collision avoidance
Authors: Serra-Gómez Álvaro , Zhu Hai , Brito Bruno , Böhmer Wendelin , Alonso-Mora Javier
Published: August 2023

Decentralized multi-robot systems typically perform coordinated motion planning by constantly broadcasting their intentions to avoid collisions. However, the risk of collision between robots varies as they move and communication may not always be needed. This paper presents an efficient communication method that addresses the problem of “when” and “with whom” to communicate in multi-robot collision avoidance scenarios. In this approach, each robot learns to reason about other robots’ states and considers the risk of future collisions before asking for the trajectory plans of other robots. We introduce a new neural architecture for the learned communication policy which allows our method to be scalable. We evaluate and verify the proposed communication strategy in simulation with up to twelve quadrotors, and present results on the zero-shot generalization/robustness capabilities of the policy in different scenarios. We demonstrate that our policy (learned in a simulated environment) can be successfully transferred to real robots.
Biodiversity in residential gardens: a review of the evidence base
Authors: Delahay Richard J. , Sherman D. , Soyalan B. , Gaston K. J.
Published: August 2023

Residential gardens are a principal component of urban green infrastructure throughout the world and their potential positive contributions to biodiversity are increasingly recognised. But the characteristics of gardens reflect the needs, values and interests of individual households. The present review summarises evidence from studies of garden biodiversity published in the scientific literature, describes major themes and identifies important knowledge gaps. A search of the Web of Science database identified 408 published articles on the biodiversity of residential gardens (1981–2022), with numbers increasing over time and a strong bias towards Europe (32.1%) and North America (23.8%). Plants and invertebrates were most frequently studied, and species diversity was often correlated with garden size and habitat complexity. Botanic composition and vegetation cover were often positively associated with the diversity and abundance of fauna. Non-native plants contributed substantially to garden plant diversity and evidence from some studies indicated benefits to other species linked to their functional attributes. Intensive management including frequent lawn mowing, fertiliser and pesticide application, and a more formal, ‘neater’ garden appearance were often associated with reduced biodiversity. However, results varied amongst studies, for example in relation to the impacts of mowing frequency on lawn diversity. There was a general paucity of experimental evidence on the impacts of different management regimes on garden biodiversity and few replicated experimental tests of recommended ‘wildlife-friendly practices’. Several studies identified the importance of connectivity amongst gardens and with other green infra-structure for species dispersal and ecosystem functioning. Emerging threats to garden biodiversity include their replacement by development, conversion to hard surfaces and declining plot sizes. Managing these challenges and maximising the biodiversity value of residential gardens requires greater engagement from policymakers and planners, and partnerships between public bodies and private households to co-ordinate local initiatives.
Genome composition in Brassica interspecific hybrids affects chromosome inheritance and viability of progeny
Authors: Katche Elvis , Katche Elizabeth Ihien , Vasquez-Teuber Paula , Idris Zurianti , Lo Yu-tzu , Nugent David , Zou Jun , Batley Jacqueline , Mason Annaliese S.
Published: August 2023

Interspecific hybridization is widespread in nature and can result in the formation of new hybrid species as well as the transfer of traits between species. However, the fate of newly formed hybrid lineages is relatively understudied. We undertook pairwise crossing between multiple genotypes of three Brassica allotetraploid species Brassica juncea (2n = AABB), Brassica carinata (2n = BBCC), and Brassica napus (2n = AACC) to generate AABC, BBAC, and CCAB interspecific hybrids and investigated chromosome inheritance and fertility in these hybrids and their self-pollinated progeny. Surprisingly, despite the presence of a complete diploid genome in all hybrids, hybrid fertility was very low. AABC and BBAC first generation (F1) hybrids both averaged ~16% pollen viability compared to 3.5% in CCAB hybrids: most CCAB hybrid flowers were male-sterile. AABC and CCAB F1 hybrid plants averaged 5.5 and 0.5 seeds per plant, respectively, and BBAC F1 hybrids ~56 seeds/plant. In the second generation (S1), all confirmed self-pollinated progeny resulting from CCAB hybrids were sterile, producing no self-pollinated seeds. Three AABC S1 hybrids putatively resulting from unreduced gametes produced 3, 14, and 182 seeds each, while other AABC S1 hybrids averaged 1.5 seeds/plant (0–8). BBAC S1 hybrids averaged 44 seeds/plant (range 0–403). We also observed strong bias towards retention rather than loss of the haploid genomes, suggesting that the subgenomes in the Brassica allotetraploids are already highly interdependent, such that loss of one subgenome is detrimental to fertility and viability. Our results suggest that relationships between subgenomes determine hybridization outcomes in these species.
Consent for Medical Treatment: What is ‘Reasonable’?
Authors: Sarela Abeezar Ismail
Published: August 2023

The General Medical Council (GMC) instructs doctors to act ‘reasonably’ in obtaining consent from patients. However, the GMC does not explain what it means to be reasonable: it is left to doctors to figure out the substance of this instruction. The GMC relies on the Supreme Court’s judgment in Montgomery v Lanarkshire Health Board; and it can be assumed that the judges’ idea of reasonability is adopted. The aim of this paper is to flesh out this idea of reasonability. This idea is commonly personified as the audience that has to be satisfied by the doctor’s justification for offering, or withholding, certain treatments and related information. In case law, this audience shifted from a reasonable doctor to a ‘reasonable person in the patient’s position’; and Montgomery expands the audience to include ‘particular’ patients, too. Senior judges have clarified that the reasonable person is a normative ideal, and not a sociological construct; but they do not set out the characteristics of this ideal. John Rawls has conceived the reasonable person-ideal as one that pursues fair terms of co-operation with other members of society. An alternative ideal can be inferred from the feminist ethic of care. However, the reasonable patient from Montgomery does not align with either theoretical ideal; but, instead, is an entirely rational being. Such a conception conflicts with both real-life constraints on rationality and the doctor’s duty to care for the patient, and it challenges the practice of medicine.
Conformational energies of reference organic molecules: benchmarking of common efficient computational methods against coupled cluster theory
Authors: Stylianakis Ioannis , Zervos Nikolaos , Lii Jenn-Huei , Pantazis Dimitrios A. , Kolocouris Antonios
Published: August 2023

We selected 145 reference organic molecules that include model fragments used in computer-aided drug design. We calculated 158 conformational energies and barriers using force fields, with wide applicability in commercial and free softwares and extensive application on the calculation of conformational energies of organic molecules, e.g. the UFF and DREIDING force fields, the Allinger’s force fields MM3-96, MM3-00, MM4-8, the MM2-91 clones MMX and MM+, the MMFF94 force field, MM4, ab initio Hartree–Fock (HF) theory with different basis sets, the standard density functional theory B3LYP, the second-order post-HF MP2 theory and the Domain-based Local Pair Natural Orbital Coupled Cluster DLPNO-CCSD(T) theory, with the latter used for accurate reference values. The data set of the organic molecules includes hydrocarbons, haloalkanes, conjugated compounds, and oxygen-, nitrogen-, phosphorus- and sulphur-containing compounds. We reviewed in detail the conformational aspects of these model organic molecules providing the current understanding of the steric and electronic factors that determine the stability of low energy conformers and the literature including previous experimental observations and calculated findings. While progress on the computer hardware allows the calculations of thousands of conformations for later use in drug design projects, this study is an update from previous classical studies that used, as reference values, experimental ones using a variety of methods and different environments. The lowest mean error against the DLPNO-CCSD(T) reference was calculated for MP2 (0.35 kcal mol−1), followed by B3LYP (0.69 kcal mol−1) and the HF theories (0.81–1.0 kcal mol−1). As regards the force fields, the lowest errors were observed for the Allinger’s force fields MM3-00 (1.28 kcal mol−1), ΜΜ3-96 (1.40 kcal mol−1) and the Halgren’s MMFF94 force field (1.30 kcal mol−1) and then for the MM2-91 clones MMX (1.77 kcal mol−1) and MM+ (2.01 kcal mol−1) and MM4 (2.05 kcal mol−1). The DREIDING (3.63 kcal mol−1) and UFF (3.77 kcal mol−1) force fields have the lowest performance. These model organic molecules we used are often present as fragments in drug-like molecules. The values calculated using DLPNO-CCSD(T) make up a valuable data set for further comparisons and for improved force field parameterization.

Graphical abstract
Impact of a Father–Child, Community-Based Healthy Lifestyle Program: Qualitative Perspectives from the Family Unit
Authors: Ashton Lee M. , Young Myles D. , Pollock Emma R. , Barnes Alyce T. , Christensen Erin , Hansen Vibeke , Lloyd Adam , Morgan Philip J.
Published: August 2023

The Healthy Dads, Healthy Kids (HDHK) program was designed to help fathers with BMI ≥ 25 kg/m2 to lose weight and positively influence physical activity and dietary behaviors of their children. There is a need to better understand the broader impact of father-focused, healthy lifestyle programs from the perspectives of other family members. This qualitative study explored the impact of a HDHK by gathering insights from the family unit (fathers, mothers/partners and children). Fathers and children who participated in the HDHK dissemination trial from the Maitland local government area (New South Wales, Australia) (n = 33) and all mothers/partners of participating HDHK were invited to take part in this qualitative study. Eleven focus groups were undertaken with 25 fathers (41.9 ± 6.3 years, 32.4 ± 5.1 kg/m2), 15 mothers/partners’ (38.1 ± 6.6 years), and 41 children (51% male, 8.2 ± 2.1 years). Audio recordings were transcribed and analyzed by an independent researcher using a standard general inductive approach to qualitative analysis with thematic analysis applied. Three key themes emerged, demonstrating several personal and family program impacts. These included a positive impact on: (i) the father-child relationship, (ii) new family habits (e.g., lifestyle changes within the family unit) and (iii) fathers’ involvement and parenting practices (e.g., increase in fathers’ household responsibilities). Improving the knowledge and skills of fathers and children through evidence-based strategies may be a useful approach to strengthen their relationship, enhance parenting strategies, and optimize health behaviors. Notably, findings showed the changes made by the fathers and children positively impacted the wider family unit.
Paleohydrological changes during the Late Holocene recorded in the sediments of two mountain lakes in the Tatra Mountains (Central Europe)
Authors: Gąsiorowski Michał , Sienkiewicz Elwira , Kowalewska Urszula , Kaucha Karolina
Published: August 2023

Changes in local hydrological and climatic conditions over the last 5500 years have been reconstructed based on geochemical and paleobiological features recorded in the sediments of two mountain lakes. The lakes are located in the Tatra Mountains, in the highest mountain range of the Carpathians (Central Europe), which during the Holocene constituted an important climatic barrier. Because both studied lakes are relatively shallow, even relatively minor fluctuations in water level are clearly recorded both in the geochemical characteristics of the sediments and in the phyto- and zooplankton communities. The multiproxy records indicate several periods of high water stands: 5.4–5.2 ka, 3.5–2.7 ka, 1.4–1.0 ka and 0.5–0 ka, and prominent dry periods 2.7–2.1 ka and 1.7–1.5 ka. Comparison of the reconstructed water levels of the Tatra lakes with records from other European regions suggests that at the boundary of the Middle and the Late Holocene, the hydrological conditions in the Tatras were similar to those in Western and Central Europe. Later, beginning approximately 3500 years ago, records from the Tatras, the northern surroundings of the Pannonian Basin, and the southern part of the Carpathians were unified. In addition to changes in local and regional hydrology, the records from the studied lakes allowed us to reconstruct changes in lake productivity. Relatively high δ13C values, compared to the sedimentary organic matter of other lakes in the region, point to in-lake primary production as a major source of sedimentary organic matter in both lakes. The stable C:N ratio values suggest a constant proportion of organic matter coming from in-lake primary production and transported from the lake catchment. However, the amount of organic carbon and nitrogen and, most of all, differences in the composition of stable C and N isotopes indicate changes in the lake environment. These changes were correlated with some paleotemperature proxies from the region.
Insights into volcanic hazards and plume chemistry from multi-parameter observations: the eruptions of Fimmvörðuháls and Eyjafjallajökull (2010) and Holuhraun (2014–2015)
Authors: Donovan Amy , Pfeffer Melissa , Barnie Talfan , Sawyer Georgina , Roberts Tjarda , Bergsson Baldur , Ilyinskaya Evgenia , Peters Nial , Buisman Iris , Snorrason Arní , Tsanev Vitchko , Oppenheimer Clive
Published: August 2023

The eruptions of Eyjafjallajökull volcano in 2010 (including its initial effusive phase at Fimmvörðuháls and its later explosive phase from the central volcano) and Bárðarbunga volcano in 2014–2015 (at Holuhraun) were widely reported. Here, we report on complementary, interdisciplinary observations made of the eruptive gases and lavas that shed light on the processes and atmospheric impacts of the eruptions, and afford an intercomparison of contrasting eruptive styles and hazards. We find that (i) consistent with other authors, there are substantial differences in the gas composition between the eruptions; namely that the deeper stored Eyjafjallajökull magmas led to greater enrichment in Cl relative to S; (ii) lava field SO2 degassing was measured to be 5–20% of the total emissions during Holuhraun, and the lava emissions were enriched in Cl at both fissure eruptions—particularly Fimmvörðuháls; and (iii) BrO is produced in Icelandic plumes in spite of the low UV levels.
Beyond Buildings: Social Bargaining and Effective Access to Public Services
Authors: Bauhr Monika , Carlitz Ruth , Kovacikova Lucia
Published: August 2023

Physical access to public services frequently does not guarantee people’s needs will be met — what we term effective access. Such discrepancies result in part from social bargaining: the extent to which citizens can leverage connections with street-level service providers. Survey data from 34 African countries shows citizens with greater social bargaining capacity enjoy greater effective access, in contrast to citizens who pay bribes. Data from 70,000 households in Tanzania further demonstrates that parents with greater social bargaining capacity have more opportunities to interact with school officials — and that their children are more likely to achieve relevant learning outcomes.
Gender Differences in Commuting: New Evidence from Spain
Authors: Casado-Díaz José M. , Simón-Albert Raquel , Simón Hipólito
Published: August 2023

This article examines the origins of the shorter commutes typically observed for women, a phenomenon that contributes to the poorer work outcomes they typically suffer. The analysis extends previous research on the gender gap in commuting by using econometric decomposition techniques that are novel in this field which, combined with a Spanish nationally representative survey that allows for an exhaustive control of the different elements identified in the literature as possible determinants of gender differences in commuting to work, allows quantifying the specific influence of a wide range of individual, family, territorial and work-related elements. The evidence obtained shows that the gender gap in commuting is not the result of the relative characteristics of women, but of the presence of a systematic pattern of lower mobility that emerges when women are compared with observationally similar men. Yet, this pattern of lower mobility is not observed for certain groups of women whose behavior in the labor market is generally more egalitarian, such as women with higher education, without family responsibilities or without a partner, which is consistent with the presence of cultural or social constraints that tend to limit women’s mobility.
Contaminants of emerging concern in urine: a review of analytical methods for determining diisocyanates, benzotriazoles, benzothiazoles, 4-methylbenzylidene camphor, isothiazolinones, fragrances, and non-phthalate plasticizers
Authors: Tkalec Žiga , Runkel Agneta Annika , Kosjek Tina , Horvat Milena , Heath Ester
Published: August 2023

Human biomonitoring (HBM) frameworks assess human exposure to hazardous chemicals. In this review, we discuss and summarize sample preparation procedures and analytical methodology for six groups of chemicals of emerging concern (CECs), namely diisocyanates, benzotriazoles, benzothiazoles, 4-methylbenzylidene camphor, isothiazolinones, fragrances, and non-phthalate plasticizers, which are increasingly detected in urine, however, are not yet widely included in HBM schemes, despite posing a risk to human health. The sample preparation procedures depend largely on the chemical group; however, solid-phase extraction (SPE) is most often used due to the minimized sample handling, lower sample volume, and generally achieving lower limits of quantification (LOQs) compared to other extraction techniques. In terms of sample analysis, LC-based methods generally achieve lower limits of quantification (LOQs) compared to GC-based methods for the selected six groups of chemicals owing to their broader chemical coverage. In conclusion, since these chemicals are expected to be more frequently included in future HBM studies, it becomes evident that there is a pressing need for rigorous quality assurance programs to ensure better comparability of data. These programs should include the reporting of measurement uncertainty and facilitate inter-laboratory comparisons among the reporting laboratories. In addition, high-resolution mass spectrometry should be more commonly employed to enhance the specificity and selectivity of the applied analytical methodology since it is underrepresented in HBM. Furthermore, due to the scarcity of data on the levels of these CECs in urine, large population HBM studies are necessary to gain a deeper understanding of the associated risks.
Sedimentary seagrass carbon stock and sources of organic carbon across contrasting seagrass meadows in Indonesia
Authors: Rahayu Yusmiana P. , Kusumaningtyas Mariska A. , Daulat August , Rustam Agustin , Suryono Devi D. , Salim Hadiwijaya L. , Ati Restu N. A. , Sudirman Nasir , Kepel Terry L. , Hutahaean Andreas A. , Adi Novi S.
Published: August 2023

Seagrass meadows are an important component of coastal ecosystems globally, and they capture and store organic carbon in living biomass and sediments. Geographical estimates of blue carbon in seagrass habitats are regionally biased, with limited information from the Indo-Pacific region, including Indonesia. Seagrass extent in Indonesia is declining rapidly, and it has been suggested that marine protected areas (MPAs) are an important instrument to support protection of seagrass ecosystems and their services. Thus, this study is aimed at quantifying and comparing sedimentary carbon stocks and sources of organic carbon from seagrass meadows located in undisturbed areas outside MPA, disturbed areas outside MPA, and within MPA in three small islands in Indonesia. The sediment carbon stocks from this study ranged from 19.81 to 117.49 Mg C ha−1, with the highest stock measured inside MPA (77.15 ± 1.38 Mg C ha−1), followed by undisturbed outside MPA (36.08 Mg C ha−1), and the lowest stock at disturbed outside MPA (21.86 ± 0.31 Mg C ha−1). The predominant source of organic carbon in disturbed meadows was from coastal POM (particulate organic matter, ~ 36%), while in MPA and undisturbed sites, the main source was from seagrass, with ~ 38% and ~ 60% contributions, respectively. The results of this study add more data and information on seagrass blue carbon potential from three different islands with different degrees of disturbance in Indonesia.
Insights into ageing rates comparison across tissues from recalibrating cerebellum DNA methylation clock
Authors: Wang Yucheng , Grant Olivia A. , Zhai Xiaojun , Mcdonald-Maier Klaus D. , Schalkwyk Leonardo C.
Published: August 2023

DNA methylation (DNAm)-based age clocks have been studied extensively as a biomarker of human ageing and a risk factor for age-related diseases. Despite different tissues having vastly different rates of proliferation, it is still largely unknown whether they age at different rates. It was previously reported that the cerebellum ages slowly; however, this claim was drawn from a single clock using a relatively small sample size and so warrants further investigation. We collected the largest cerebellum DNAm dataset (N = 752) to date. We found the respective epigenetic ages are all severely underestimated by six representative DNAm age clocks, with the underestimation effects more pronounced in the four clocks whose training datasets do not include brain-related tissues. We identified 613 age-associated CpGs in the cerebellum, which accounts for only 14.5% of the number found in the middle temporal gyrus from the same population (N = 404). From the 613 cerebellum age-associated CpGs, we built a highly accurate age prediction model for the cerebellum named CerebellumClockspecific (Pearson correlation=0.941, MAD=3.18 years). Ageing rate comparisons based on the two tissue-specific clocks constructed on the 201 overlapping age-associated CpGs support the cerebellum has younger DNAm age. Nevertheless, we built BrainCortexClock to prove a single DNAm clock is able to unbiasedly estimate DNAm ages of both cerebellum and cerebral cortex, when they are adequately and equally represented in the training dataset. Comparing ageing rates across tissues using DNA methylation multi-tissue clocks is flawed. The large underestimation of age prediction for cerebellums by previous clocks mainly reflects the improper usage of these age clocks. There exist strong and consistent ageing effects on the cerebellar methylome, and we suggest the smaller number of age-associated CpG sites in cerebellum is largely attributed to its extremely low average cell replication rates.
Analysis of human well-being as the area of protection in social life cycle assessment
Authors: Lindkvist Mathias , Ekener Elisabeth
Published: August 2023

Purpose

Social life cycle assessment (S-LCA) has been developed for almost two decades for assessing the social impacts of product life cycles. Only a limited amount of research, however, considers the full range of social sustainability that is impacted by the cause-effect relationships in the impact pathway (IP) approach in S-LCA. The aim of this study is to provide guidance on the ultimate purpose of S-LCA by presenting an up-to-date overview on human well-being (HWB).

Methods

Due to the broadness of the purpose of presenting and assessing an up-to-date set of HWB components, our study was designed as a qualitative literature review. The review includes core characteristics of a qualitative systematic review, a realist review, and an umbrella review. We designed the operationalised review to result in a synthesised HWB component set and guidance on its use. In order to achieve this, we searched for theoretical lenses on how HWB component sets relate to other HWB approaches, searched for HWB component sets, and identified S-LCA relevant sustainability aspects and tested these on the component sets. The component sets were found in sustainability science, philosophy, psychology, and development studies.

Results and discussion

The study resulted in a framework that contains both a HWB component set and guidance on its use. The set consists of the five components: having a healthy life; having competencies; having influence and enjoying freedom; having a meaningful life; and enjoying fair treatment. This approach is by philosophers denoted an objective goods list, containing “goods” that are seen as intrinsic parts of HWB because they so clearly can support humans in their lives. Other philosophical perspectives suggest that either desires in choice situations impacting the objective goods or the experienced mental states resulting from the goods, ultimately matters to humans. Challenges with the goods approach are how to define a good life and to relate to actual human activity.

Conclusions

The presented updated definition of a HWB components set and guidance on it can benefit developers and practitioners of S-LCA, and in particular the IP approach, by illustrating the scope of social sustainability and the challenge of defining it. Regarding the scope, several other social sustainability aspects than health have been shown to matter. Regarding the challenge of defining social sustainability, it remains to see what the path forward is taking this challenge into account.
Identification of a diarylpentanoid-producing polyketide synthase in the biosynthesis of 2-(2-phenylethyl)chromones in agarwood
Authors: Morita Hiroyuki , Lee Yuan-E , Shi She-Po
Published: August 2023

Agarwood has been valued as an exquisite, high-grade fragrant wood since ancient times. Due to the scarcity of high-quality agarwood, it is quite expensive, and the number of original plants has been drastically reduced due to overharvesting, including illegal logging. Despite this, a reliable method of agarwood cultivation has yet to be developed. Thus, identifying the biosynthetic pathways of the fragrant components in agarwood might help developers to optimize the culture conditions and create artificial agarwood, by monitoring the expression of the biosynthetic enzymes or their genes. This review presents the characteristics of our recently identified key enzyme, 2-(2-phenylethyl)chromone precursor synthase (PECPS), which generates the common precursor of 2-(2-phenylethyl)chromones (PECs), the main fragrances in agarwood, as well as our reasoning to reach these conclusions. We also discuss the biosynthetic pathway of PECs, unveiled following the identification of PECPS.
Endoscopic measurement of the size of gastrointestinal polyps using an electromagnetic tracking system and computer vision-based algorithm
Authors: Safavian Nazanin , Toh Simon K. C. , Pani Martino , Lee Raymond
Published: August 2023

Purpose

Polyp size is an important factor that may influence diagnosis and clinical management decision, but estimation by visual inspection during endoscopy is often difficult and subject to error. The purpose of this study is to develop a quantitative approach that enables an accurate and objective measurement of polyp size and to study the feasibility of the method.

Methods

We attempted to estimate polyp size and location relative to the gastro-oesophageal junction by integrating data from an electromagnetic tracking sensor and endoscopic images. This method is based on estimation of the three-dimensional coordinates of the borders of the polyp by combining the endoscope camera position and the corresponding points along the polyp border in endoscopic images using a computer vision-based algorithm. We evaluated the proposed method using a simulated upper gastrointestinal endoscopy model.

Results

The difference between the mean of ten measurements of one artificial polyp and its actual size (10 mm in diameter) was 0.86 mm. Similarly, the difference between the mean of ten measurements of the polyp distance from the gastroesophageal junction and its actual distance (~ 22 cm) was 1.28 mm. Our results show that the changes in camera positions in which the images were taken and the quality of the polyp segmentation have the most impact on the accuracy of polyp size estimation.

Conclusion

This study demonstrated an innovative approach to endoscopic measurements using motion tracking technologies and computer vision and demonstrated its accuracy in determining the size and location of the polyp. The observed magnitude of error is clinically acceptable, and the measurements are available immediately after the images captured. To enhance accuracy, it is recommended to avoid identical images and instead utilise control wheels on the endoscope for capturing different views. Future work should further evaluate this innovative method during clinical endoscopic procedures.
Evaluation of the clinical behavior of unclassified renal cell carcinoma and its imaging findings on computed tomography and magnetic resonance imaging based on World Health Organization (WHO) 2022
Authors: Yamamoto Akira , Tamada Tsutomu , Higaki Atsushi , Arita Yuki , Ueno Yoshiko , Murakami Takamichi , Jinzaki Masahiro
Published: August 2023

Objectives

To ascertain the clinical behaviors of unclassified renal cell carcinoma (RCC) and its characteristic imaging findings on CT and MRI.

Methods

Subjects in this retrospective study were 10 patients who had received a histological diagnosis of unclassified RCC based on World Health Organization (WHO) 2022 and who had undergone CT and/or MRI prior to surgery. In terms of clinical behaviors, TNM classification, stage, postoperative recurrence, time to recurrence, and postoperative survival were evaluated. In terms of imaging findings, tumor size, growth pattern, CT density, dynamic contrast-enhancement (DCE) pattern, internal appearance, presence of a pseudocapsule, and signal intensity on MRI were evaluated. We compared clinical behaviors and imaging findings, and investigated associations between them.

Results

One patient could not be followed-up due to death from other causes. Postoperative recurrence was observed in 4 patients, all of whom had Stage 3 RCC. In the remaining 5 patients without recurrence, all 5 patients showed Stage 2 or below. On imaging, unclassified RCC tended to be large (58.7 mm) and solid (100%), and heterogeneous interiors (80%), cystic degeneration (80%) and high intensity on diffusion-weighted imaging (DWI) (71.4%) were common. Comparing patients with and without recurrence, the following findings tended to differ between recurrence and recurrence-free groups: tumor size (73.4 ± 33.9 mm vs. 50.2 ± 33.9 mm, P = 0.286), growth pattern (invasive: 100% vs. 0%, expansive: 0% vs. 100%, P = 0.008 each), DCE pattern (progressive enhancement pattern, 66.7% vs. 0%, washout pattern, 0% vs. 66.7%, P = 0.135 each) and presence of a pseudocapsule (25% vs. 80%, P = 0.167).

Conclusion

The clinical behavior of unclassified RCC varies widely. Although imaging findings are also variable, findings of large, heterogeneous tumors with cystic degeneration and high intensity on DWI were common. Several imaging findings such as large size, invasive growth, progressive enhancement pattern and no pseudocapsule may enable prediction of prognosis in unclassified RCC.
Efficacy observation of pushing Qiaogong point with different intensities for treating stage I essential hypertension
Authors: Feng Yue , Duan Zhengting , Chen Dongnan , Ye Senlin , Dou Shulin
Published: August 2023

Objective

To observe the clinical efficacy of pushing Qiaogong point with varying intensities for treating stage I essential hypertension.

Methods

A total of 72 patients diagnosed with stage I essential hypertension were enrolled in this study. They were divided into three groups using the random number table method, including a control group, a gentle pushing group, and a heavy pushing group, with 24 patients in each group. All three groups received the same therapeutic lifestyle interventions. The control group received no additional interventions, the gentle pushing group received additional pushing Qiaogong point with gentle strength, and the heavy pushing group received additional pushing Qiaogong point with heavy strength. The treatment duration was 4 weeks, followed by a 4-week follow-up period, during which blood pressure changes were observed and analyzed in all three groups.

Results

After treatment, the blood pressure levels in all three groups showed a significant decrease (P<0.05). The effective rate in the control group was 43.5%, in the gentle pushing group was 78.3%, and in the heavy pushing group was 33.3%. The reduction in blood pressure levels in the gentle pushing group was significantly superior to that in both the control group and the heavy pushing group, indicating inter-group statistical significance (P<0.01). The efficacy of the heavy pushing group was comparable to that of the control group, indicating no statistical significance (P>0.05). During the follow-up period, compared with the end of the treatment within the same group, the blood pressure levels remained stable in both the control group and the gentle pushing group, indicating no intra-group statistical significance (P>0.05). The heavy pushing group showed a significant decrease in diastolic blood pressure (DBP) and mean blood pressure (MBP) compared with the end of the treatment, indicating intra-group statistical significance (P<0.05). During the follow-up, the gentle pushing group had lower systolic blood pressure (SBP) and MBP compared with both the heavy pushing group and the control group, indicating inter-group statistical significance (P<0.01), while there was no inter-group statistical significance in comparing the DBP (P>0.05). There was no statistical significance in comparing the SBP, DBP, and MBP between the heavy pushing group and the control group (P>0.05).

Conclusion

Pushing Qiaogong point with gentle strength combined with lifestyle interventions showed a higher effective rate and long-term blood pressure stability in the treatment of stage I essential hypertension. Pushing Qiaogong point with varying intensities showed varying effects on patients with stage I essential hypertension.
Leveraging B2B field service technicians as a “second sales force”: How service situations affect selling activity and success
Authors: Berkmann Manuel , Eisenbeiss Maik , Reinartz Werner , Schauerte Nico
Published: August 2023

To extract the full revenue potential of their front line, B2B firms use their technical field service force for selling activities. However, as selling is only a complementary activity embedded in technicians’ main service tasks, they may struggle to sell effectively. The authors investigate the service situation as a key driver of (i) the technician’s decision to engage in selling (selling activity) and (ii) the customer’s decision to purchase (selling success). They identify four types of service situations with unique effects on these outcomes. Notably, technicians’ selling activity is highest (+ 10% compared to baseline) in service situations that offer a lower (-22%) likelihood of success, whereas activity is lower in the most promising situations. Thus, technicians do not properly exploit sales opportunities. The extent of inefficiencies moreover varies by employee-specific moderators, such that specialized technicians and those with little practical experience have particular difficulty exploiting excellent sales opportunities.
Medicine in history and history in medicine: the inaugural Davis Coakley Memorial Lecture
Authors: Kelly Brendan D.
Published: August 2023

Professor Davis Coakley (1946–2022) was an outstanding physician, historian, and leader of reform in medical services and education. This inaugural Davis Coakley Memorial Lecture, delivered in The Edward Worth Library at Dr Steevens’ Hospital, Dublin, Ireland, on 28 September 2023, focuses on ‘Medicine in History & History in Medicine’. It explores the position of the physician-historian in medical historiography, discusses Coakley’s extensive historical work (especially his many books about the history of medicine), and concludes with comments about one of Coakley’s great interests: the work of Sir William Wilde (1815–1876). Sir William was a prominent Victorian doctor, father of playwright Oscar, and remarkably prescient commentator on public health in Ireland. Sir William’s comments about patterns of epidemics are especially arresting and relevant today in the immediate wake of COVID-19. Coakley’s interest in Sir William echoed Coakley’s broader commitment to medical care, progressive education, and genuine scholarship that shed light on suffering, illness, healing, and recovery. The fields of both medicine and history are greatly enriched by Coakley’s life and work.
The Intersection of Female Sexual Function and Overactive Bladder
Authors: Shoureshi Poone S. , Eilber Karyn S.
Published: August 2023

Purpose of Review

In this review, we discuss the available literature regarding the intersection of female sexual function and overactive bladder (OAB). Specifically, this review includes how OAB and its treatments affect female sexual function and quality of life.

Recent Findings

Women suffering from overactive bladder have worse sexual function, and there are multiple prospective studies evaluating sexual function before and after overactive bladder treatment.

There is a growing body of evidence demonstrating that traditional overactive bladder treatments not only improve OAB but can also improve sexual function.
Application of a Multiplex Ligation-Dependent Probe Amplification-Based Next-Generation Sequencing Approach for the Detection of Pathogenesis of Duchenne Muscular Dystrophy and Spinal Muscular Atrophy Caused by Copy Number Aberrations
Authors: Yang Yongchen , Xia Chaoran , Song Xiaozhen , Tang Xiaojun , Nie Xueling , Xu Wuhen , Du Chengkan , Zhang Hong , Luo Peng
Published: August 2023

Both Duchenne muscular dystrophy (DMD; OMIM no. 310200) and spinal muscular atrophy (SMA; OMIM no. 253300/253550/253400/271150) are genetic disorders characterized by progressive muscle degeneration and weakness. Genetic copy number aberrations in the pathogenetic genes DMD and SMN1 lead to alterations in functional proteins, resulting in DMD and SMA, respectively. Multiplex ligation-dependent probe amplification (MLPA) has become a standard method for the detection of common copy number aberrations (CNAs), including DMD and SMN1 deletions, both of which are associated with poor clinical outcomes. However, traditional MLPA assays only accommodate a maximum of 60 MLPA probes per test. To increase the number of targeted sequences in one assay, an MLPA-based next-generation sequencing (NGS) assay has been developed that is based on the standard MLPA procedure, allows high-throughput screening for a large number of fragments and samples by integrating additional indices for detection, and can be analyzed on all Illumina NGS platforms.
Adapting Ourselves, Instead of the Environment: An Inquiry into Human Enhancement for Function and Beyond
Authors: Döbler Niklas Alexander , Carbon Claus-Christian
Published: August 2023

Technology enables humans not only to adapt their environment to their needs but also to modify themselves. Means of Human Enhancement — embodied technologies to improve the human body’s capabilities or to create a new one — are the designated means of adapting ourselves instead of the environment. The debate about these technologies is typically fought on ethical soil. However, alarmist, utopian, and science fiction scenarios distract from the fact that Human Enhancement is a historical and pervasive phenomenon incorporated into many everyday practices. In the vein of disentangling conceptual difficulties, we claim that means of Human Enhancement are either physiologically or psychologically embodied, rendering the merging with the human user their most defining aspect. To fulfill its purpose, an enhancement must pass the test-in-the-world, i.e., assisting with effective engagement with a dynamic world. Even if failing in this regard: Human Enhancement is the fundamental and semi-targeted process of changing the users relationship with the world through the physical or psychological embodiment of a hitherto external object and/or change of one’s body. This can potentially change the notion of being human. Drawing on a rich body of theoretical and empirical literature, we aim to provide a nuanced analysis of the transformative nature of this phenomenon in close proximity to human practice. Stakeholders are invited to apply the theory presented here to interrogate their perspective on technology in general and Human Enhancement in particular.
Are Women the “Keepers of the Culture”? A Study on the Gender-Specific Transmission and Development of Mainstream and Ethnic Identities using Latent Growth Curve Models
Authors: Stache Randy
Published: August 2023

Migration scholars repeatedly claim that mothers in migrant families are responsible for cultural preservation and that this responsibility is passed on to their daughters. In turn, male family members are claimed to be more oriented towards the majority society. This often assumed “keepers of the culture” hypothesis is assessed here using bivariate conditional latent growth curve models to track identity developments in a multigroup comparison. The analysis uses information from second-generation youth and their parents from the CILS4EU data. After a review of the mechanisms that may lead to such a gendered effect, the empirical comparison of parent-child dyads reveals that, contrary to expectations, sons and daughters undergo the same identity development during adolescence. Moreover, both parents pass on their identities to both genders in the same way. I discuss the consequences of these results on an empirical and theoretical level at the end of this paper.
Effectiveness of nature-based walking interventions in improving mental health in adults: a systematic review
Authors: Ma Jingni , Lin Peilin , Williams Joanne
Published: August 2023

Nature-based walking interventions represent a low-cost, eco-friendly activity, designed to assist people in maintaining physical well-being and improving their mental-health status. This systematic review aims to evaluate the evidence regarding the effectiveness of nature-based walking interventions in the improvement of mental health outcomes in adults. This paper draws upon Applied Social Sciences Index & Abstracts (ASSIA), PsycINFO, MEDLINE, EMBASE, the Web of Science Core Collection, Doctoral thesis databases (ProQuest), and manual searches. Due to the heterogeneity of the eligible studies, a narrative synthesis was employed. The present review includes 1,209 adult participants, of whom 336 were female; it also involves 17 discrete studies. The evidence from this systematic review suggests that nature-based walking interventions can indeed improve adults’ moods, sense of optimism, mental well-being, and nature connectedness. They simultaneously mitigate stress, anxiety, and negative rumination. In addition, compared with urban walking, nature-based walking interventions may bring greater benefits vis-à-vis anxiety and rumination. This review contributes to the synthesis of evidence for nature-based walking interventions, and identifies several research gaps around the topic. In clinical practice, nature-based interventions may be used to relieve one’s negative mood, stress, and anxiety. To enhance treatment efficacy, however, they should be combined with formal modes of psychotherapy.
The role of pyroptosis-related lncRNA risk signature in ovarian cancer prognosis and immune system
Authors: Wu Yanling , Liang Lei , Li Qin , Shu Lilu , Wang Peter , Huang Shufeng
Published: August 2023

Ovarian cancer is a leading cause of death in females with gynecologic cancers. Pyroptosis is a relatively new discovered programmed cell death that is believed to be associated with inflammation. However, studies on pyroptosis-related lncRNAs in ovarian cancer are limited. In this study, we identified 29 pyroptosis-related genes and screened out 72 pyroptosis-related lncRNAs. Furthermore, the 72 lncRNAs were eliminated to 2 survival-related lncRNAs using Cox regression and Lasso regression to build an ovarian cancer prognostic prediction signature and were further validated on the test set. We adopted a riskscore from the two-gene signature, and the survival in low-risk group was higher than the high-risk group. Functional enrichment analysis indicated that the differentially expressed genes (DEGs) between two risk groups were associated with tumor immunity. This study implies that pyroptosis-related genes are closely related to tumor immunity and could be potential therapeutic factors for ovarian cancer treatment.
Classification and function of γδT cells and its research progress in anti-glioblastoma
Authors: Zhao Yujuan , Zhu Renhong , Wang Yashu , Wang Keqiang
Published: August 2023

Human peripheral blood T lymphocytes are classified into alpha–beta T (αβΤ) cells and gamma–delta T (γδΤ) cells based on the difference in T cell receptors (TCRs). αβT cells are crucial for the acquired immune response, while γδΤ cells, though only a small subset, can recognize antigenic substances. These antigens do not need to be processed and presented and are not restricted by MHC. This distinguishes γδΤ cells from αβT cells and highlights their distinct role in innate immunity. Despite their small number, γδΤ cells hold significant significance in anti-tumor, anti-infection and immune regulation. Glioblastoma (GBM) represents one of the most prevalent malignant tumors within the central nervous system (CNS). Surgical resection alone proves to be an ineffective method for curing this type of cancer. Even with the combination of surgical resection, radiotherapy, and chemotherapy, the prognosis of some individuals with glioblastoma is still poor, and the recurrence rate is high. In this research, the classification, biological, and immunological functions of γδT cells and their research progress in anti-glioblastoma were reviewed.
Heat and shear stability of particle stabilised foams for application in gluten-free bread
Authors: Schmid T. , Leue-Rüegg R. , Müller N.
Published: August 2023

Bread forms an integral part of the daily diet in many cultures worldwide. At the same time, a significant number of people try to avoid wheat-based products for either health reasons or due to personal preferences. The absence of a protein network in gluten free bread affects its structure, taste, texture and shelf-life. This paper suggests a technological solution to this issue that uses a pre-foamed mass of gluten free raw materials which is mixed with the bread’s ingredients, then kneaded and baked to form a high quality gluten free bread. To survive the high shear stresses during kneading and temperature increase during baking, the foam requires exceptional stability. This stability was achieved through particle stabilisation of the bubble interfaces. Both of the tested foams (with and without particles) exhibited thermal stability up to 80 °C. However, resistance to shear stresses was higher in the particle stabilised foams. Of all the tested particles, linseed press cake and banana powder led to the best results. In conclusion, particle stabilised foams seem very well suited to applications in gluten free baked goods. Further application potential is seen for vegan foamed desserts.