bluuebunny/crossref_metadata_2025 huggingface dataset:
TERAPIAS NEUROPROTECTORAS Y FÁRMACOS EMERGENTES EN EL TRATAMIENTO DEL ICTUS: AVANCES RECIENTES.
Authors: Menoscal Cristóbal Lenin Fajardo , Intriago Israel Andrés Bermudez , Quiñonez Diana Karina López , Cisneros Loreley Vanessa Calvas , Zambrano Nicole Lissette Vásquez , Rivera Laura Stefany Barrera , A Evelin Zulime Asencio De La , Calderón Fernando Alexander Bravo , Honores Félix Jossue Solano , Nieto Kristy Madelaine Arriciaga , Siguencia Ronald Jonathan Cañarte , Antepara Bismarck Stiven Pazmiño
Published: August 2024

El ictus, también llamado accidente cerebrovascular (ACV), es una afección cerebrovascular aguda que interrumpe el flujo sanguíneo al cerebro, lo que conduce a daños neuronales y disfunción cerebrall, siendo una de las principales causas de discapacidad y mortalidad a nivel mundial. A pesar de los esfuerzos en prevención y tratamiento, sigue siendo un desafío médico debido a la falta de terapias efectivas y seguras. Objetivo: Analizar avances recientes en terapias neuroprotectoras y fármacos emergentes para el ictus. Metodología:  Se realizó una búsqueda exhaustiva en bases de datos como PubMed, Scopus y Google Académico. Se seleccionaron estudios publicados en inglés y español desde 2018 hasta la fecha actual, incluyendo revisiones sistemáticas, metaanálisis, ensayos clínicos y estudios observacionales relevantes. Resultados: Se destacan varios fármacos y productos naturales con potencial terapéutico para el tratamiento del ictus. Por ejemplo, la quercetina ha mostrado efectos beneficiosos en modelos animales de isquemia cerebral, reduciendo la permeabilidad de la barrera hematoencefálica y mejorando la función neurológica. Otros compuestos como la vinpocetina, el SY-007, y el Protopanaxatriol (PPT) también muestran promesas, aunque se necesitan más investigaciones clínicas para confirmar su eficacia y seguridad. Los productos naturales como la puerarina, la pinocembrina, el EGCG y el resveratrol han demostrado propiedades antioxidantes, antiinflamatorias y neuroprotectoras, mostrando efectos positivos en la reducción del daño cerebral isquémico y la mejora de la función neurológica en modelos animales. Conclusiónes: Los avances en terapias neuroprotectoras y fármacos emergentes para el tratamiento del ictus son prometedores, pero se necesita más investigación para traducir estos hallazgos en beneficios clínicos tangibles para los pacientes.
COMPLICACIONES POSTOPERATORIAS EN EL REEMPLAZO DE VÁLVULA MITRAL: REVISIÓN DE LA LITERATURA .
Authors: Menoscal Cristóbal Lenin Fajardo , Intriago Israel Andrés Bermudez , Quiñonez Diana Karina López , Zambrano Nicole Lissette Vásquez , Rivera Laura Stefany Barrera , A Evelin Zulime Asencio De La , Calderón Fernando Alexander Bravo , Honores Félix Jossue Solano , Nieto Kristy Madelaine Arriciaga , Siguencia Ronald Jonathan Cañarte , Antepara Bismarck Stiven Pazmiño , Chang Ivonne Magaly Andrade
Published: August 2024

El reemplazo de válvula mitral es una intervención crucial para abordar diversas afecciones cardíacas, pero conlleva riesgos significativos de complicaciones postoperatorias. Objetivo: Analizar las complicaciones postoperatorias asociadas con el reemplazo de la válvula mitral. Metodología: Se realizó una revisión bibliográfica exhaustiva en bases de datos médicas, seleccionando estudios desde el año 2014 hasta la actualidad y evaluando la calidad y relevancia de los mismos. Resultados y Discusión: Se identificaron diversas complicaciones postoperatorias, como hemorragias, tromboembolismo, arritmias, problemas de la prótesis valvular y otras cardíacas y vasculares. Se discutieron factores de riesgo, estrategias de prevención y manejo para cada complicación, destacando la importancia del control del ritmo cardíaco, la anticoagulación y la monitorización postoperatoria. Conclusiones: La revisión revela la complejidad y diversidad de los desafíos clínicos en pacientes sometidos a reemplazo de válvula mitral. Se enfatiza la importancia de estrategias preventivas y terapéuticas basadas en evidencia, así como el seguimiento adecuado y la colaboración multidisciplinaria para mejorar los resultados a largo plazo y reducir la morbimortalidad en esta población.
INTERNAÇÕES HOSPITALARES POR TRANSTORNOS MENTAIS DEVIDO AO USO DE ÁLCOOL E SUBSTÂNCIAS PSICOATIVAS: UMA AVALIAÇÃO DE 2018 A 2023
Authors: Lima Andressa Bianca Reis , Carvalho Clara Vitoria Cavalcante , Sampaio Marcos Vinicius Diocesano , Schoemberger Yasmin Czervenny , Resende Ítalo Naftaly Silva , Castro Isabelli Zeitz de , Mendonça Thiago Dutra , Sousa Wanderson Fortes de , Corrêa Júlia Maria Silva , Crespo Lívia Maia , Cruz Carla Tatiellen Nunes Pereira , Santos Ana Irene Silva dos , Franco Emília Mafra , Pereira Luana Cristina dos Santos , Luz Renata Maria Soares Eloi , Vale Lucas Andre Sousa , Viana Matheus Durand Rodrigues Ribeiro
Published: August 2024

O Brasil é o país que apresenta as maiores taxas de transtornos de ansiedade e o quinto em casos de depressão, o que leva os indivíduos a buscar o uso de álcool e substâncias psicoativas como mecanismo para aliviar o sofrimento mental. O presente trabalho tem o objetivo de analisar o panorama clínico e epidemiológico dos casos de dengue no sudeste brasileiro de 2014 a 2023. Trata-se de um estudo descritivo, quantitativo e retrospectivo, com base em dados obtidos através do Sistema de Morbidade Hospitalar (SIH) no Departamento de Informática do Sistema Único de Saúde (DATASUS). O total de internações por transtorno mental associado ao uso de álcool e substâncias psicoativas no Brasil, entre 2018 e 2023, foi de 435.923. A região Sul apresentou o maior número de casos (n=181.455), sendo o Rio Grande do Sul o estado responsável por mais de 54,69% dessas internações. A faixa etária com maior frequência de casos foi a de 30 a 39 anos, correspondendo a 26,89% (n=117.234) dos casos. A amostra foi, em sua maioria, composta por indivíduos do sexo masculino, correspondendo a 81,15% (n=353.754) do total. A cor/raça mais frequente na amostra analisada foi a branca, correspondendo a 45,88% (n=200.010) dos casos. A maioria dos atendimentos foi feita em caráter de urgência, correspondendo a 84,61% dos casos. A média de permanência foi de 20,4 dias de internação. Durante o período analisado, houve 2.472 óbitos, dos quais a maior parte eram indivíduos entre 50 e 59 anos, representando 24,91% do total. O estudo evidenciou um padrão de crescimento no número de casos, principalmente entre a população mais jovem, o que pode levar a uma grave dependência química.
Peningkatan Hasil Belajar Siswa tentang Gerak Lurus dengan Menerapkan Model NHT di Kelas X MIPA 1 SMAN 2 Solok
Authors: Susanti Rosi
Published: August 2024

This research aims to increase the student’s learning achievement about straight movement by applying NHT model at grade X of natural. Science class I Physics  is one of the subjects that is not interesting to some of the student of SMAN 2 Solok. Because it is considered as a difficult subject, so that they tend to be passive to join the physics class. One of the models to increase the student  activeness is NHT model. This research is an action research by having collaboration between the researcher and the researcher and the physics teacher. The subject research are 36  student of  SMAN 2 Solok,grade X of natural science class I In year  of  2021/2022. The technique of data collection uses student’s activities observation space and student’s test marks. The result show that by applying NHT model at the material of straight movement at grade x of natural science I at SMA 2 Solok. There is increase to: (1). The student’s activities at cycle I that is 72,9%, then at the cycle 2 it become 95 %, the percentage increasing is 22,9%.(2).Teacher’s activeness at the first meeting is 73,07% and getting increases to the forth meeting to 90,74%. It increases 17,67%  with the very good predicate, and (3).The student learning achievement, at the cycle 2 there are 5 students (14%) got very good score, 25 students(69,5%) got good score, 5 students(14%) got middle score, and there is only I student(24,77 %) got the lowest score.
RETURNS OF SOCIAL AND PRIVATE INVESTMENT IN VOCATIONAL EDUCATION IN NIGERIA
Authors: Isunueo Benedicta Omeghie  , Akinola Ebenezer Olanrewaju
Published: August 2024

Globally, the world of work has shifted its focus from just education obtained through theoretical courses to vocational education and training because of the recorded returns in social and private investment. Thus, the sector has been at the heart of recent economic reforms worldwide. However, despite the upsurge in the supply of academic university graduates in Nigeria, employers of labor still face a supply shortage of skilled labor and this has been linked to the theory-oriented curricula of academic universities which do not prepare students for skill-intensive jobs. According to the Nigerian Bureau of Statistics report (2024), statistics the overall unemployment rate in Nigeria for the Q2 of 2023 was 4.2%, while among youth aged 15-24 years, the unemployment rate in Q2 of 2023 was 7.2%, up from 6.9% in Q1 2023. Meanwhile, in urban areas, the unemployment rate reached 5.9% in 2022, compared to 5.4% in Q1 2023. Within vocational training, the economic returns to practical or in-plant training seem to be slightly higher than those in school training. It is clear that tremendous resources, both human and material, are required to redress the situation. As Nigeria is lagging in preparing its workforce for the challenges of the rapidly changing global economy, the government must invest captiously and pay particular attention to vocational and technical education. Also, there is the need to improve the earnings of vocational school graduates through an increase in salary and attractive remuneration which will induce individuals to take vocational education and skills acquisition more seriously.
KEYWORDS: Vocational Education, Education, Returns, Social and Private Investment and Nigeria.
LINGUISTIC ABILITY OF THE PERSON, SPEECH AND COMMUNICATIVE COMPETENCE
Authors: Zukhro Akbarova
Published: August 2024

This paper deals with the issue of linguistic ability of the person, speech and communicative competence. This article clarifies that the concept of personality is one of the most controversial issues in the field of linguistics. Scientists have created many theories in this regard, each of them presents its own definition of the concept.
KEY WORDS: personality, language carrier, communicative competence, development
Percepción de Exclusión Social, Ansiedad y Depresión en Personas Lesbianas, Gays, Bisexuales y Heterosexuales del Noroeste de México
Authors: Campos Valdez Guadalupe , Flores-Verduzco Guadalupe Refugio , Manríquez-Betanzos Juan Carlos
Published: August 2024

Las personas lesbianas, gays y bisexuales se caracterizan por atravesar más situaciones de exclusión y efectos
negativos en la salud psicológica en contraste con los heterosexuales. El objetivo del estudio fue comparar los niveles de percepción de exclusión social, ansiedad y depresión entre un grupo de lesbianas, gays y bisexuales y otro grupo de heterosexuales. Se analizaron las respuestas de una muestra no probabilística por conveniencia de 190 personas del noroeste de México con edades de 18 a 42 años (M = 22.84, DE = 4.11), quienes respondieron el instrumento de percepción de exclusión social de Téllez y Rivera y los inventarios de ansiedad y depresión de Beck. Los resultados demostraron que el grupo de lesbianas, gays y bisexuales indican mayores niveles de moderado a extremo/severo en percepción de exclusión social, ansiedad y depresión en contraste con la muestra de heterosexuales. Se discute que las afectaciones físicas, mentales y sociales se presentan más en personas que comparten públicamente sus orientaciones sexuales diversas en un sistema con mayor índice de individuos heterosexuales.
The Role of Central Asian and South Caucasian Economies in Foreign Trade of the Republic of Türkiye
Authors: Chediya Anri , Karamourzov Renat
Published: August 2024

Based on the data of the World Integrated Trade Solution of the World Bank, this paper discusses the role of the Central Asian and South Caucasian economies in the foreign trade of the Republic of Türkiye. In order to obtain comparable results, Türkiye's exports to the Central Asian and South Caucasian regions and imports from the former to the latter are considered in constant prices. The observation shows that both trade flows increased during the period under consideration. For most of the years, many of the countries remained net importers of Turkish goods, as their exports to Türkiye exceeded the value of the goods they purchased from Türkiye. Only three of the eight countries - Kazakhstan, Tajikistan, and Uzbekistan - were net exporters to Türkiye for most of the period. The analysis shows that the largest buyers of Turkish exports in the regions were Azerbaijan, Georgia, and Uzbekistan, which together consumed more than 2.5% of total Turkish exports in 2019. In total, Central Asia and South Caucasus bought more than 3% of Turkish exports, which is quite comparable to the shares of Türkiye's trading partners such as the Netherlands, France, Spain, the US, and Italy. The share of Central Asia and South Caucasus in Türkiye's imports was much less significant.
Methodological approaches to sustainable deve-lopment management of enterprises in conditions of instability
Authors: Nemashkalo Karina , Khakhaliev Dmytro , Manuilov Oleksii
Published: August 2024

This article examines methodological approaches to managing the sustainable development of enterprises under conditions of instability, highlighting the growing unpredictability of economic, social, and environmental factors impacting businesses. An integrated approach to management is characterized by considering the interconnections between economic, social, and environmental aspects of enterprise activities. This approach aims to mitigate adverse environmental and societal impacts while ensuring economic success. Its advantages include reducing negative factors, promoting stable development, and gaining reputational benefits. The risk-oriented approach identifies, assesses, and manages enterprise activity risks. This approach's strengths include flexibility and adaptability to changing external conditions, enhancing competitiveness, and preventing losses. The innovative approach emphasizes the development of new technologies, products, and processes. The managerial approach involves the active participation of management and staff in decision-making processes related to sustainable development. Essential aspects of this approach include employee engagement, conscious leadership, and fostering a corporate culture oriented toward sustainability. The benefits include increased employee motivation and involvement, support from leadership, and the development of a relevant corporate culture. An analysis of the potential for integrating these approaches reveals opportunities for achieving a balance between economic efficiency, social responsibility, and environmental sustainability. In conclusion, the proposed strategies consider all aspects of sustainable development and provide a comprehensive approach to managing enterprises under conditions of instability. These strategies aim to integrate economic, social, and environmental goals, proactive risk management, fostering innovation, engaging personnel, leveraging digital technologies, and developing strategic partnerships.
Keywords: sustainable development, change management, social responsibility, economic sustainability, innovation, corporate social responsibility (CSR), global transformational processes, adaptation to changes.
Development of agricultural competences as a priority factor of the sustainable development of Ukraine’s economy
Authors: Shabatura Tеtіana , Livinskyi Anatoliy
Published: August 2024

Statement of the problem and its relevance. The intensification of crisis phenomena in the modern labor market in Ukraine is characterized by the insufficient level and number of specialists in the agricultural sector trained by the higher education system, the strengthening of the imbalance between the demand and supply of labor in Ukraine and abroad, large-scale destruction and risks, low labor efficiency and an insufficient and unstable level its payments in the agricultural sector. The current state, problems, and prospects of strengthening agro-economic competencies are studied. The purpose of providing modern educational services is to train future personnel capable of managing a modern enterprise based on environmental friendliness and circularity, to carry out the production and sale of environmentally safe food products that meet the needs of consumers, considering force majeure circumstances, changes in the culture of consumption and projected needs for strengthening the sustainability of business processes for future generations. Education for sustainable development requires the immediate development and implementation of a comprehensive program of continuous training and education of students in ecology, environmental protection, and rational nature management. Recently, as a result of the war, Ukraine has suffered significant losses of economic, ecological, social, and educational potential. This hurt the socio-economic indicators of the country's development, living standards, and population size. Changes to the legislation on several educational measures for adapting young people to new conditions and post-war reconstruction are proposed, and the main elements and competencies adapted to the modern risk conditions of economic development in the agrarian sphere are substantiated. Ukrainian agriculture can realize significant potential only by training young people with a high moral and ethical level who share the world values of sustainable development and care for the environment, an environment important for full entry into the global food market. Knowledge is of excellent importance for recovery and further sustainable socio-economic development in the information society's formation conditions. Their formation takes place as a result of the educational sector fulfilling its mission of socio-economic upliftment.
Keywords: sustainable development, agrarian education, competitiveness, sustainable development strategies, post-war competences of the growth of the agro-industrial sector, efficiency of agricultural enterprises, modernization of institutions of higher agrarian education, agrarian economy.
Modern principles of development and increase of the competitiveness of tourist activities of the Odessa region
Authors: Kalyna Tеtiana , Arzumanyan Tеtiana , Biletska Natalia
Published: August 2024

Currently, one of the guarantors of the region's economic stability is the development of tourism. The rapid growth of the tourism industry and significant cash receipts actively affect various segments of the economy and contribute to the formation of the tourism industry. The development of domestic tourism is a significant source of income for local economies, ensures the creation of jobs, promotes self-employment of the population, and contributes to the development of regions. In this vein, the study of the peculiarities of the development of domestic tourism in the regions and the increase of the competitiveness of tourist activity in the conditions of current realities is not just important, but urgent.
The publication's purpose is to engage you, the reader, in the research of the specifics of development and assess the competitiveness of tourism in the Odesa region. Your interest and involvement in this study are crucial for its success and for the advancement of the tourism industry in the Odesa region.
The results. The article examines the essence and nature of the popularity of tourism at the regional level. The essence of tourism is determined; it is substantiated that it affects the world economy and is dependent on crisis phenomena. It has been studied that our country is an attractive destination for tourism from all over the world; the tourism sector continues to need help with difficulties and focuses mainly on domestic tourism to safe regions. It is noted that the Odesa region is one of the most popular regions of Ukraine for tourism and recreation. Odesa's tourist and recreational potential, the leading economic indicators of tourism such as the contribution to GDP, employment generation, and foreign exchange earnings, the dynamics of the number of subjects of tourist activity, and the dynamics of the payment of the tourist tax have been studied. It is substantiated that tourism needs to rethink the directions of specialization and diversification of tourist services with an orientation, first of all, on domestic tourism in the context of increasing its competitiveness.
Conclusions. The analysis of tourist activity in Odesa shows that the region is developing in tourism, which, in turn, brings income to the regional budget and contributes to forming a favorable reputation of the region as an attractive tourist destination. Therefore, the development of regional tourist destinations and the formation of their tourist attractiveness is extremely important in order to achieve the goals of the region's socio-economic development in the conditions of growing competition in the market of tourist services.
Keywords: tourism, tourist activity, competitiveness of tourism, region, tourist destination
Wawasan Kebangsaan sebagai Cara Pandang Masyarakat Mereduksi Pemilih Apatis dalam Menyongsong Pemilu yang Demokratris dan Pastisipatif
Authors: Lestari Sulistyani Eka , Mangkunegara RM. Armaya , Nugroho Aguk , Muhari Muhari , Harysart Vivin Astharyna
Published: August 2024

Keberagaman masyarakat Indonesia, sebagai Negara Kesatuan Republik Indonesia (NKRI), memiliki potensi untuk memicu perpecahan apabila tidak dikelola dengan baik. Laporan ini membahas pentingnya wawasan kebangsaan sebagai cara pandang masyarakat untuk mereduksi sikap apatis pemilih menjelang pemilu 2024. Wawasan kebangsaan di sini mencakup pemahaman tentang identitas nasional dan persatuan berdasarkan Pancasila, Bhinneka Tunggal Ika, NKRI, dan UUD 1945. Sikap apatis dan potensi golput dalam pemilu sering kali dipicu oleh retorika politik dan kampanye yang mengandalkan agitasi serta propaganda. Oleh karena itu, diperlukan sosialisasi dan edukasi kepada masyarakat untuk meningkatkan partisipasi pemilih secara aktif dan rasional. Melalui kegiatan pengabdian kepada masyarakat oleh dosen Fakultas Hukum Universitas Sunan Bonang, dilakukan sosialisasi dan edukasi wawasan kebangsaan di Desa Saringembat, Kecamatan Singgahan, Kabupaten Tuban. Kegiatan ini bertujuan untuk mendukung pemerintah dalam mensukseskan pemilu 2024 dengan meningkatkan semangat nasionalisme dan partisipasi pemilih. Metode yang digunakan meliputi pendekatan partisipatif dan deskriptif, dengan pemaparan wawasan kebangsaan dan simulasi pelaksanaan pemilu untuk mewujudkan pemilu yang jujur dan demokratis.
The I-Guana Shot Protocol, An Intracavernosal Application of Wharton's Jelly Stem Cells for the Treatment of Erectile Dysfunction, Phase II Study
Authors: Tepos Eduardo Vega
Published: August 2024

Umbilical cord has become an increasingly used source of mesenchymal stromal cells for preclinical and, more recently, clinical studies. Different clinical uses on multiple anatomical structures have demonstrated the safe use of the umbilical cord tissue and derivates with multiple potentially different options to treat difficult diseases or clinical conditions. Immunophenotypic analysis and characterization of stem cells isolated from Wharton’s jelly via various methods is currently underway in clinical research. Stem cells are the body’s basic cells from which all other cells with specialized functions are generated. Under the right conditions in the body or perinatal environment, stem cells divide to form more new cells. These new cells become stem cells (self-renewal type of cells), and can also become specialized cells (differentiated) with more specific functions, such as blood cells, brain cells, heart muscle, urinary and genital tract, bone, etc. No other cell in the body has the natural ability to generate new cell types as stem cells do. As with any emerging scientific/medical field having such incredible potential, numerous research trials and data gathering efforts are currently being conducted world-wide. New data is being reported daily that present compelling cases for therapies using certain pathologies on selected patients. Scientists have been working for decades to harness the regenerative “power” of stem cells for the possible repair and rejuvenation of certain organs to activate tissue regeneration. The ultimate objectives of all these studies are the same: deliver transformative therapies. The capacity for these cells to transform into whatever cells or tissues that the body may need to regenerate itself could, within the next 3 generations, potentially provide the means to successfully treat blindness, spinal cord injuries, diabetes, cystic fibrosis, muscular dystrophy, or even erectile dysfunction in affected patients. Such future outcomes may be possible for candidate patients who are fortunate enough to have access to those scientific and evidence- based medical protocols that use such potent biological sources. It is vital that, in the light of the dazzling potential, mesenchymal stem cells research and medical applications continue, especially for compassionate medical use (e.g. for No Option patients).
Prevalence of Depression in Patients with Chronic Pain
Authors: Mashour Moutasem Al
Published: August 2024

Background: Chronic pain is a distressing health crisis with a profound physical and emotional impacts. There is an association between chronic pain and depression. This study aimed at examining prevalence of depression in patients with chronic pain and determining the link between medications used in chronic pain and depression. Methods: In a cross-sectional study, 201 participants who fit the criteria of chronic pain and attended the pain management clinic, Salmaniya Medical Complex, Bahrain over a period of five months were included. Data about depression was collected from participants using validated Patient Health Questionnaire (PHQ-9). Results: The prevalence of 44.3% of depression was detected in patients with chronic pain. Males to females represented a proportion of 49.3% vs 50.7%, majority of them had sickle cell disease (74.1%). Bivariate analysis expressed that none of the examined variables was significantly different among depressed and non-depressed patients (P>0.05). Univariate analysis found that increased age, male patients, and absence of limitation in daily activity were less prone to severe depression, however, opioid-treated patients, and rarely or intermittently drug intake are more liable to increased depression severity (P<0.05). Conclusions: Adult patients with chronic pain treated at specialty pain clinics were observed to have high levels of depression, with a negative association between the opioids use and depression. Thus, the recognition of the psychological burden of chronic pain emphasizes the necessity of taking action. Reducing the burden of chronic pain on healthcare systems and enhancing patient health and function are two benefits of effective depression treatment.
Early Diagnostic and Management of Acute Heart Failure: Can Cardiogenic Shock be Prevented?
Authors: Simao Antonio Felipe Leite
Published: August 2024

Background: Heart failure is a growing health concern, affecting about 2% of the adult population. It emphasizes the importance of recognizing and addressing a specific subgroup of patients suffering from acute heart failure (AHF). AHF is described as a critical clinical condition often overlooked in diagnosis, leading to catastrophic outcomes if not promptly identified. Given its potential severity, understanding the unique characteristics of AHF, along with appropriate therapeutic interventions, is crucial for improving patient outcomes and reducing mortality rates. Methods: The study included 20 patients with heart failure and reduced ejection fraction who presented with decompensated clinical conditions characteristic of acute heart failure. Data were collected preoperatively, perioperatively, and postoperatively up to a 30-day follow-up period. Results: The primary outcome was the 30-day mortality, which was found to be 20%. Among the patients with AHF, 60% had congestive heart failure with an average ejection fraction of 29.8%, indicating severe ventricular dysfunction. Additionally, 45% of patients presented with chronic kidney injury, characterized by a low mean glomerular filtration rate and elevated urea and creatinine levels. The presence of acute congestive and retention syndrome was evident in these patients, exacerbating the underlying disease. Notably, 10% of patients required left ventricular assistance devices, and associated procedures were performed as part of the surgical management of heart failure. Conclusion: The failure to recognize the diagnosis of this serious acute condition can quickly lead to patient’s death. Although, AHF showed 30-days high mortality rate, early diagnose, decongestive therapy and myocardial revascularization had avoided worst outcomes in cardiogenic shock.
Superior Vena Cava Syndrome and Cardiac Tamponade Caused by Hodgkin’s Lymphoma in An 8 Year-Old Girl
Authors: Mayombo I Michael
Published: August 2024

Superior vena cava syndrome is a medical emergency and most often manifests in patients with malignant disease process within the thorax. A cardiac tamponade is a clinical syndrome caused by the accumulation of fluid in the pericardial space, resulting in reduced ventricular filling and subsequent hemodynamic compromise. Superior vena cava syndrome and symptomatic pericardial effusion occurring as the initial presentation of Hodgkin's lymphoma is uncommon, and the documented literature is limited. Authors present the case of an 8-years old girl who presented with a superior vena cava syndrome and a cardiac tamponade revealing a highly suspected Hodgkin’s Lymphoma. Patient underwent an emergency subxiphoid percutaneous drainage and a pleuropericardial window. The biopsy was consistent with high suspicion of Hodgkin’s Lymphoma. Through this case, authors aim to emphasize the importance of promptly reaching a diagnosis, as it can help prevent severe complications and enhance the patient's prognosis.
Ketamine attenuates hypoxia-induced cell death and oxidative toxicity via inhibition of the TRPM2 channel in neuronal cells
Authors: Osmanlıoğlu Haci Ömer
Published: August 2024

Ketamine (KET) is a pediatric anesthetic agent, and it acts antioxidant action via the inhibition of Ca2+ influx and N-methyl-D-aspartate (NMDA) receptors, apoptosis, intracellular (iROS), and mitochondrial reactive oxygen species (mROS) productions. Hypoxia (HYP)-induced oxidative stress activates the TRPM2 channel, although 2-aminoethoxydiphenyl borate (2APB) inhibits it. The treatment of KET inhibits HYP-induced oxidative stress and apoptosis in neuronal cells, although conflicting information is also present. We aimed to the modulator role of KET on the HYP-mediated oxidative cytotoxicity and apoptosis in the SH-SY5Y neuronal cells via modulating the TRPM2 signaling pathways. We induced five primary groups in the SH-SY5Y cells: Control, KET (0.3 mM for 24h), HYP (CoCl2 and 200 M for 24h), HYP+KET, and HYP+2APB. The amounts of apoptosis, cell death (propidium iodide positive cell number), oxidants (mROS and iROS), and cytosolic free Ca2+ were increased via TRPM2 stimulation by the incubation of HYP, although their amounts were diminished by KET and 2APB. In conclusion, the treatment of KET attenuated the HYP-induced oxidative stress and neuronal death levels via TRPM2 inhibition in the SH-SY5Y neuronal cells. The KET may be considered as a potential therapeutic way to HYP-induced oxidative neuronal injury.
Perancangan Aplikasi Kamus Air Traffic Control Berbasis Mobile Android
Authors: Hondor Saragih  , Ajeng Hidayati
Published: August 2024

This study discusses the Air Traffic Controller dictionary where this dictionary will discuss all the initials that have developed in the world of air police, which so far all information about the rules in regulating flights is only in written form (Manual Dictionary). The purpose of this study is to help air transportation speed directors recall some of the existing definitions in the world of aviation, so that it is hoped that there will be no more misunderstandings between pilots and air transportation speed controllers. The method used by the author is the waterfall method, where the flow is Analysis, Design, Implementation and testing. The Unified Modeling Language design will help readers understand this research. The results of this study illustrate that the application can run on an Android mobile device.
Effects of Brassica Rapa on Dyslipidaemia and Oxidative Damage in Rats Consuming a Hyperlipidic Diet
Authors: El kadi Fatima , Yerou Karima , Khelladi Hadj
Published: August 2024

This research investigated the influence of a hyperlipidic diet in Wistar rats and the therapeutic effect of Brassica rapa powder (BrP). A hyperlipidic diet was administered followed by oral supplementation of BrP (5%) for 28 days. The BrP supplementation caused a decrease in weight (- 41%), glycaemia (-12%), creatinemia (-51%), aspartate aminotransferase (AST) level (-80%), and cholesterolaemia (-25%) associated with an increase in HDLc level (+59%). However, the hepatic lipid profile showed a decrease in phospholipids (PL) (-59%) and total cholesterol (TC) (-67%). In addition, oxidative stress assessment showed a decrease in the serum (-22%), renal (-30%) and adipose (-8%) levels of TBARS. Furthermore, BrP supplementation boosted glutathione (GSH) protective activity in adipose tissue with a maximum of +49%. In conclusion, Brassica rapa enhances the serum and tissue balance of metabolic and antioxidant status.
KEYWORDS
Antioxidant, biomarkers, fat, in vivo, redox status, turnip
Green synthesis of pyrrole-fused dibenzoxazepine/dibenzothiazepine/­triazolobenzodiazepine derivatives via isocyanide-based multicomponent reactions
Authors: Norouzi Marzieh , Nazeri Mohammad Taghi , Shaabani Ahmad , Notash Behrouz
Published: August 2024

An efficient and facile synthesis of pyrrole-fused dibenzoxazepine/dibenzothiazepine/ triazolobenzodiazepine derivatives were developed through the isocyanide-based multicomponent reaction of isocyanides, gem-diactivated olefins and cyclic imines such as dibenzoxazepine, dibenzothiazepine and triazolobenzodiazepine under solvent- and catalyst-free conditions. Purposefully, this approach produced various biological scaffolds using environmentally friendly, mild, and simple conditions. Due to their bioactive moieties, these compounds with exclusive fluorescence properties may attract great attention in biomedical applications, clinical diagnostics, and conjugate materials.
The artisanal turn as another search for the “lost time” (Proust) by Ukrainian intellectuals and the plane of their representation
Authors: Chmil Hanna
Published: August 2024

In the proposed study, the so-called “artisanal turn” is comprehended in the context of the metamodern cultural and philosophical paradigm, the peculiarities of the metamodern situation in philosophy and art. Invoking arguments of domestic authors who study metamodern ideas in domestic scientific thought, their influence on the state of modern culture and art, it is proved that reflections on the peculiarities of cultural and artistic life go beyond postmodernism and require addressing the situation of metamodernity. The overlap in traditional, postmodern and metamodern cultural codes testifies in favor of metamodernity as a cultural stage of the development of society and a philosophical trend reflected by cultural metamodernity in connection with the “artisanal turn” in art. Because this turn is a new look at people, culture, new avant-garde aesthetics, original artistic styles. The metamodern artistic paradigm is a new modality of the transdeductive relationship of people to things and transindividual relationships between people, and a cosmic artisan is a relational subjectivity. Art “returns” to the artisanal age of the sixteenth century Middle Ages, which leads to the deceptive illusion of craftsmanship as a sphere of realization of personal authenticity, both from the point of view of theory and artistic practice, but in this there is more of a modern alchemical minimalism, analogous to the mode of activity of the cosmic artisan described by Deleuze and Guattari with its inherent manneristic virtuosity which was truly new.
The discussion of the issue of the “metaphysics of the artisanal turn”, the return of craftsmanship and mannerism in modern crafts helps artists clarify their place in culture and assert their professional authenticity through created artistic values, and for philosophers the concept of the “artisanal turn” illuminates its main meaning and specific meanings, subjective and objective parameters, a logical and emotional component of a fundamentally new aesthetics of beauty, which was initiated by the surrealism of the 20th century.
The problem of definition and substantive evolution of the research subject of Ukrainian cultural research
Authors: Holotenko Pavlo
Published: August 2024

The main incentive for carrying out this research work was the need to specify the meaningful paradigm of Ukrainian cultural research through the definition of its subject, as a complex-structural concept of “culture”. The subject is the basis of science, similarly to the methodology and the conceptual and categorical apparatus. Given the aggravation of the crisis state of modern Ukrainian cultural studies, the study of such thematic direction is of quite urgent importance.
The article reveals one of the key hindering factors in understanding the specifics of cultural research, which in turn creates a pluralism of interpretations of the essence of this science. The problem of defining the specificity of “scientific” in relation to cultural research and other types of scientific practices is analyzed. The content variability of the subject of cultural knowledge during the historical development of cultural research as a science is considered, similar to the evolution of the research subject of other scientific disciplines. Information is provided regarding the approximate number of currently existing definitions of the concept of “culture” as a subject of the study of cultural research, according to the calculations of various scientists. A typology of interpretations of culture based on content and a complex of means of conceptual expression is established. A comparative analysis was carried out and an integrating synthesis was made of various definitions of culture, the authors of which are well-known representatives of cultural thought – E. Taylor, U. Thomas, L. White and others.
Implementasi Sistem Informasi Akuntansi Kredit Gadai Emas Di PT Pegadaian
Authors: Meilinda Yesica , Triandi Triandi , Pramiudi Udi
Published: August 2024

This research was prepared to determine the procedures for granting, repaying, and auctioning gold pawn loans at PT Pegadaian (Persero) Tajur Branch Service Unit as one of the Fast and Secure Credit products offered by the company to the public to be able to obtain loans with collateral in the form of gold. The purpose of this writing is to find out about the Gold Pawn Credit Accounting Information System at PT Pegadaian and how the effectiveness of Internal Control on the Gold Pawn Information System at PT Pegadaian. The procedure for granting a gold pawn starts from a credit application, valuation of collateral, disbursement of credit loan funds, to storage of collateral, followed by settlement of the loan money within a maximum of four months by redemption, installments, or renewal. If the customer is unable to repay later, the collateral will be auctioned with the customer's consent based on the terms and conditions at the beginning of the credit loan process. Based on the results of the review, all of the above procedures have been carried out by the principles of good internal control, including standard procedures that are outlined in the form of flowcharts, there is a separation of duties made in the organizational structure and job descriptions, there are appraisers to overcome the risk of the insufficient value of collateral, there are adequate authorization procedures when granting credit and the auction process, there is verification of credit granting requirements, security of pawn deposits is very adequate, supported by a pawn application system and supporting documents to ensure the achievement of the objectives of granting credit with gold pawning.
 
Keywords: Gold Pawn Credit Procedure, Internal Control, Accounting Information System
Implementasi Saluran Distribusi Pada PT Surya Donasin
Authors: Ramdani Muhamad Ridwan , Nurendah Yulia , Sulistiono Sulistiono
Published: August 2024

Distribution channels play a very important role in the success of a company's marketing. because distribution is the spearhead of the company in marketing products or services. Products reach consumers directly or indirectly through distribution channels. In choosing the most appropriate distribution channel to use, the company must be in accordance with the conditions and objectives of the company. Distribution channels are the core of the company's efforts to distribute goods from producers to consumers. The author's purpose of this study is to find out: 1) Implementation of distribution channels at PT Surya Donasin, 2) What are the obstacles to implementing distribution channels at PT Surya Donasin, 3) Efforts to deal with obstacles to implementing distribution channels at PT Surya Donasin. The results of the review conducted, 1) The distribution channel carried out by PT Surya Donasin uses an intensive distribution channel to obtain a wider market. 2) Constraints in implementing distribution channels, namely, market potential that has not been covered, payment administration that does not match the specified time, lack of human resources and facilities to support the distribution process, procurement of goods that are often out of stock. 3) Efforts to overcome obstacles, namely, the Supervisor makes visits to check each store, checks stores that still have bills that are past the payment time, adds resources and facilities as needed, always maintains inventory so that out of stock does not occur
 
Keywords: distribution channels, implementation, marketing
Impact The Covid 19 Pandemic on the Tourism Business Stakeholders Performance in Bogor City
Authors: Marpaung Annaria Magdalena , Hadi Cecilia Valentina Sri , Marpaung Bintang Sahala
Published: August 2024

Pandemic and Tourism Business Performance
 
 
_____1147
 
 
Submitted:
MAY 2024
 
 Accepted:
JULY 2024

 

This study done with objective For know How impact covid 19 pandemic against performance of the perpetrators business restaurants and hotels . Deep sample this study are the perpetrators business restaurant and hotel located in the city of Bogor . Data collection was carried out with do interview direct with perpetrator business . Research result show application Policy Health Protocols in sectors tourist  give impact positive form obedience  public . Ownership CHSE certificate , provide impact positive on the entity industry supporter tourist Hotel and Destination category Tourism , and not give influence significant in the Restaurant category
 
Keywords: Covid 19 pandemic , activities business , CHSE.
Examination of Housing Quality in The Peri-Urban Areas of Akure, Nigeria
Authors: Lawal Olubunmi Lukman , Omole Felix Kayode , Basorun Joseph Omoniyi
Published: August 2024

Rapid urban population expansion, high living costs, and a need for affordable housing all encourage migration to Akure’s peri-urban districts. This drive has led to increased land utilization for housing development in peri-urban areas. This study evaluated housing quality in the peri-urban areas of Oba-Ile, Oda, and Ibule-Soro in Akure. Households were the unit of analysis, with one household head per building selected for questionnaire administration. Based on an average household size of five people per family and five households per building in Ondo State, the total number of households in the three locations was 47,110. From the 47,110 households, 800 households (1.7%) were randomly selected for the questionnaire administration. Data from the field survey were subjected to statistical analysis. The results revealed that some buildings were structurally unsound; most buildings had corrugated iron roofs and lacked sanitation infrastructure; and open defecation was commonplace, particularly in Ibule-Soro. These findings call for better urban planning and investment in basic amenities to improve housing quality and living standards in peri-urban areas.
A Semiotic Analysis of Nonverbal Linguistic Signals Used On Billboard Posters as a Means of Creating Public Awareness During the Covid-19 Pandemic in Douala
Authors: Fuh Ngonjo Victor
Published: August 2024

This paper examines the use of nonverbal linguistic signals on billboard posters during the Covid-19 pandemic in Douala. It has been noticed that nonverbal signals such as sweating, wearing a nose mask, washing of hands with clean running water and soap and standing two metres apart from each other and the use of colours such as white and red among others play an important role in the way human beings communicate especially during a period of crisis. Although it is nonverbal, this means of communication acts more than the verbal one. This work focuses on nonverbal linguistic features used on billboard posters in the city of Douala as a means of creating public awareness in relation to the Covid-19 pandemic so that the contamination and mortality rate can be reduced. This study is of great value because it demonstrates how people should live during a pandemic era without being contaminated. This research uses a qualitative research design. The researcher culled some pictures that were pasted on billboards during the crisis (2020-2021) on the streets of Douala. Insight was drawn from Barthes (1964) theory of semiotics.  The findings indicated that people washed their hands with clean running water and soap, they wore masks, arrows were used to show how people should stand with others in public, colours such as red was used to show how dangerous this virus is and the white colour was also used to indicate that people need to be clean during this period so that they can minimise the chances of being contaminated. Capitalisation was used either in red or black to attract the attention of the public to the messages written on the billboards. The researcher concludes that people should develop the culture of reading public notices especially billboard posters during epidemics and pandemics so that they can save their lives.
Animo Bertani di Kalangan Generasi Muda di Desa Bandungan Kecamatan Bulango Utara Kabupaten Bone Bolango
Authors: Alipu Regina , Musa Farid Th. , Harold Rudy
Published: August 2024

Agriculture in Indonesia is currently facing a problem: the decreasing number of young people willing to take over roles from the older generation in the agricultural sector. The purpose of this research is to understand the interest of the younger generation in agriculture, both in terms of attraction and lack thereof. This study employs methods to comprehend the situation by collecting data through observation, interviews, and documentation. The research results indicate that, first, many young people are not interested in farming because they view agriculture as an unpromising, outdated profession that does not align with their lifestyle. Second, several factors influencing the lack of interest among the younger generation in farming include the low prestige associated with agriculture, an imbalance between the agricultural process and its unsatisfactory outcomes, the influence of the surrounding environment, the emergence of new subcultures in the digital era, and a lack of knowledge and support for agriculture.