bluuebunny/crossref_metadata_2025 huggingface dataset:
Towards Sustainable Interior Design Education In Egypt
Authors: Mahmoud El-Zeney Rasha
Published: October 2017

The need to introduce issues of sustainability into the interior design curriculum has become critically important. So the purpose of this study was to investigate the current status of teaching sustainability in curricula of interior design programs in Egypt universities; assess the level of awareness and training background on sustainability and determine the obstacles to incorporating sustainability into the programs. Interior design lecturers and professors were invited to participate in a survey on their university's interior architecture curricula. The study shows that all interior design programs currently do not teach sustainability within their curricula, and there are some obstacles to teaching sustainability.
Modern Innovative Solutions to Improve Outcomes in Asthma, Breathlessness, and Chronic Obstructive Pulmonary Disease (MISSION ABC): Protocol for a Mixed-Methods Study (Preprint)
Authors: Lanning Eleanor , Heiden Emily , Longstaff Jayne , Fogg Carole , Brown Thomas , Rupani Hitasha , Dewey Ann , Neville Daniel , Jones Thomas , DeVos Ruth , Mottershaw Mark , Bassett Paul , Chauhan Anoop J
Published: October 2017

BACKGROUND

A high proportion of the costs for respiratory diseases are generated by a relatively small group of patients with severe disease (recognized or unrecognized) or complex problems that include multimorbidity, at-risk behaviors, and socioeconomic disadvantage. These patients often struggle to engage with the structured, proactive, care approaches for chronic disease management advocated for asthma and chronic obstructive pulmonary disease (COPD), resulting in repeated emergency use of both primary and secondary health care. An integrated approach for the management of complex patients, incorporating both specialist and primary care teams’ expertise, may be effective in improving outcomes for such high-risk patients. However, the evidence is mixed, and there is a need for evaluation of models of integrated care in routine “real-world” clinical settings.

OBJECTIVE

This mixed-methods protocol examines the implementation of a novel integrated care model for patients with airways disease and undifferentiated breathlessness by using both quantitative and qualitative evaluation of processes, patient and health care professional experiences, and clinical outcomes throughout the clinic cycles. It aims to establish whether Modern Innovative Solutions to Improve Outcomes in Asthma, Breathlessness, and Chronic Obstructive Pulmonary Disease (MISSION ABC), including innovative diagnostic and self-management tools, can deliver improvements in health service use and clinical outcomes for the different patient groups (asthma, breathlessness, and COPD) and compares the 12-month period prior to the first patient visit and the 6-month period following the last visit.

METHODS

A combination of study designs is required to evaluate all aspects of the service: participatory action research approach, involving real-time evaluation at each clinic to inform subsequent clinics; before-and-after study for patient outcomes before and after clinic attendance; and qualitative methods (interviews and focus groups).

RESULTS

The results will be compiled and published in April 2019.

CONCLUSIONS

Evaluation of the clinic cycles will include consideration of qualitative data from patients, carers, and health care professionals in addition to quantitative outcomes for service implementation and patient factors. The long-term impact of the service will be evaluated using clinical and health service outcomes.

INTERNATIONAL REGISTERED REPOR

DERR1-10.2196/9228
Predicting Depression From Language-Based Emotion Dynamics: Longitudinal Analysis of Facebook and Twitter Status Updates (Preprint)
Authors: Seabrook Elizabeth M , Kern Margaret L , Fulcher Ben D , Rickard Nikki S
Published: October 2017

BACKGROUND

Frequent expression of negative emotion words on social media has been linked to depression. However, metrics have relied on average values, not dynamic measures of emotional volatility.

OBJECTIVE

The aim of this study was to report on the associations between depression severity and the variability (time-unstructured) and instability (time-structured) in emotion word expression on Facebook and Twitter across status updates.

METHODS

Status updates and depression severity ratings of 29 Facebook users and 49 Twitter users were collected through the app MoodPrism. The average proportion of positive and negative emotion words used, within-person variability, and instability were computed.

RESULTS

Negative emotion word instability was a significant predictor of greater depression severity on Facebook (rs(29)=.44, P=.02, 95% CI 0.09-0.69), even after controlling for the average proportion of negative emotion words used (partial rs(26)=.51, P=.006) and within-person variability (partial rs(26)=.49, P=.009). A different pattern emerged on Twitter where greater negative emotion word variability indicated lower depression severity (rs(49)=−.34, P=.01, 95% CI −0.58 to 0.09). Differences between Facebook and Twitter users in their emotion word patterns and psychological characteristics were also explored.

CONCLUSIONS

The findings suggest that negative emotion word instability may be a simple yet sensitive measure of time-structured variability, useful when screening for depression through social media, though its usefulness may depend on the social media platform.
Hospital cost impact of orbital atherectomy with angioplasty for critical limb ischemia treatment: a modeling approach
Authors: Shammas Nicolas W , Boyes Christopher W , Palli Swetha R , Rizzo John A , Martinsen Brad J , Kotlarz Harry , Mustapha JA
Published: October 2017

Aim:The incremental cost of peripheral orbital atherectomy system (OAS) plus balloon angioplasty (BA) versus BA-only for critical limb ischemia was estimated.Materials & methods:A deterministic simulation model used clinical and healthcare utilization data from the CALCIUM 360° trial and current cost data. Incremental cost of OAS + BA versus BA-only included differential utilization during the procedure and adverse-event costs at 3, 6 and 12-months.Results:For every 100 procedures, incremental annual costs to the hospital were US$350,930 lower with OAS + BA compared with BA-only. Despite higher upfront costs, savings were realized due to reduced need for revascularization, amputation and end-of-life care over 6–12-month postoperative period.Conclusion:Atherectomy with OAS prior to BA was associated with cost savings to the hospital.
Nuevas miradas psicológicas al "ser mujer:" despertar, transgredir y renacer en el arte
Authors: Hernández Mella Rocío , Pacheco Salazar Berenice
Published: October 2017

El pensamiento accidental ha sido históricamente un instrumente un instrumento de legitimación, naturalización y perpetuación de las relaciones desiguales de poder entre hombre y mujeres. Dentro de un contexto patriarcal, la llamada "identidad femenina" suele entenderse a partir de una concepción martirológica del amor, el apego a los estereotipos de belleza y la maternidad; configurándose la culpa en las mujeres a partir del sentirse en incumplimiento ante las expectativas sociales desarrolladas desde la masculinidad dominante. Visto esto, uno de los objetivos de toda terapia psicológica ha de ser el desmonte de los roles estereotipados de género, el desmonte de la masculinidad dominante y el empoderamiento de las mujeres. Igualmente, la incorporación de lo artístico permite recrear la vida, sanar el alma, y re-inventar lo humano con amplio sentido simbólico, así como hacer de las terapias psicológicas procesos también espirituales.
An Urgent Need for More Ethnographic Study of Business Creation
Authors: Lidow Derek
Published: October 2017

Notes from the Corner Office:An Urgent Need for More Ethnographic Study of Business Creation
“Safety Fatigue”: Symptoms, Causes, Solutions
Authors: M. Kessler John
Published: October 2017

I have had the pleasure of many visits to Brazil since 2001. During these visits, I have collaborated with ANVISA on training programs at the start of the Sentinel Hospital program. I have lectured on medication safety topics to students, practitioners, private companies, and healthcare administrators. I have worked closely with safety organizations such as ISMP- Brazil, a national leader in promoting safety awareness and safe practices. I have seen Brazil experience an awakening to the problems of safety in healthcare. Over these last 16 years, good things have happened because of the personal dedication of professionals, leaders, and organizations devoted to safety. There have been well-attended local, regional and national congresses on safety. In general, there is an appetite for learning how to be safer and how to make changes that improve quality.
Tenability of the research program of realism in international relations
Authors: Lisanin Mladen
Published: October 2017

It is the author?s intention to explore the realist theory in International
Relations in the context of Imre Lakatos?s Methodology of Scientific Research
Programs. To this end, after defining the notion of realism in IR and
exposing the foundations of Lakatos?s analytical pattern, relevant findings
of several authors who took part in the debate on this issue from the area of
philosophy of science (John Vasquez, Kenneth Waltz, Stephen Walt, Thomas
Christensen and Jack Snyder, Colin Elman and Miriam Fendius Elman, Randall
Schweller, William Wohlforth) will be presented and critically analyzed. In
that sense, there are two key lines of dispute: about whether Lakatos?s
methodology is properly utilized in evaluating realist theory, and whether it
represents an adequate tool for such a metatheoretical endeavor in the first
place. In the concluding part of the article, author?s findings which point
toward tenability of the realist research program, along with a limited scope
of applicability of Lakatos?s methodology in the field of International
Relations.
The theory of neoliberal institutionalism at the beginning of XXI century: International institutions and global governance
Authors: Prorokovic Dusan , Milicevic-Prorokovic Jelena
Published: October 2017

Neoliberal institutionalism represents the fourth phase in the development of
the liberal institutionalism theory. Unlike the previous ones, at this stage
of development, theorists focus on international institutions as independent
actors in international relations, which are not only the means for the
states to realize their national interests, but also influence internal
policy in the countries. Ultimately, this leads to seeing the international
relations outside the realistic ?self-help principle? as ones defining the
behavior of states. The ambiguity in the further positioning of neoliberal
institutionalism is regarding the phenomenon of global governance. The global
governance is becoming reality. Because of this, states are often forced to
act beyond their particular interests, giving priority to solving problems
through international institutions. However, this largely does not happen due
to state decisions, but thanks to the activities of non-state actors.
Although the international politics stay state-centered, nongovernmental
organizations and multinational corporations have more influence in
overcoming anarchy through global governance and the establishment of rules
of the game in certain areas of life. For neoliberal institutionalism, this
presents somewhat a challenge. The development of the fourth phase of the
liberal institutionalism will depend on future explanations regarding the
relation to global governance.
Critical international relations theory at the beginning of the 21st century
Authors: Dabic Dragana
Published: October 2017

The article deals with contemporary tendencies and research in the field of
critical theory of international relations. Focusing on the analysis of
global power relations, this specific approach within the framework of the
science of international relations, draws attention to the different
capacities of international actors to influence their own political and
economic circumstances. Its contribution to the science of international
relations is reflected in the opening (and politicization) of issues that the
representatives of traditional theories take as a given fact, or for various
reasons do not pay needed attention. The article will present the evolution
of the critical theory of international relations, ranging from the radically
critical point of view of its founder Robert Cox to the strictly normative
orientation of Jurgen Habermas. Contrary to the question of the
?inevitability? of the existing world order (on which the realists insist in
particular), as well as the acceptability of dominant patterns and practice
of demonstration of power in world politics, it offers alternative visions of
the architecture of global relations. It is concluded that the critical
theory of international relations, despite numerous criticisms, is relevant,
because it approaches the phenomenon of power in a diametrically opposite
way, in comparison to the traditional schools of thought in international
relations. It provides researchers with analytical tools, so that they can
identify the role and significance of both ideas (theory) and practices
(political actions) in creating and maintaining the structures of the world
order.
Correlation between periodontal soft tissue and hard tissue surrounding incisors in skeletal Class III patients
Authors: Park Jeong-Ho , Hong Ji-Yeon , Ahn Hyo-Won , Kim Su-Jung
Published: October 2017

Objectives:

To investigate the association between the periodontal soft tissue, alveolar bone and dental parameters surrounding the incisors at baseline in patients with skeletal Class III malocclusion.

Materials and Methods:

The study sample comprised 154 teeth from 28 patients with skeletal Class III malocclusion (19 men and 9 women, 21.15 ± 4.02 years). Periodontal soft tissue examination and hard tissue measurements with cone-beam computed tomography (CBCT) were performed. Factor analysis was used to reduce the CBCT variables, and correlation analysis between the hard tissue factors and soft tissue parameters was performed. Differences in hard tissue parameters between thick and thin gingival types were evaluated.

Results:

CBCT measurements were reduced to three hard tissue factors: lingual plate, coronal-buccal plate, and apical-buccal plate. Keratinized gingiva width and thickness were positively correlated with the coronal-buccal plate factor and negatively correlated with the apical-buccal plate factor. In the thin gingival biotype, mandibular incisors were more proclined, and the apical part of the buccal alveolar plate and the coronal part of lingual alveolar plate were thicker than in the thick gingival biotype.

Conclusions:

In the anterior teeth in cases of skeletal Class III malocclusion, hard tissue structures on the buccal side can be grouped based on coronal and apical factors that are significantly correlated with keratinized gingival width and thickness. Thick and thin gingival biotypes exhibited differences in tooth inclination and alveolar plate thickness with regard to the mandibular incisors.
Improving the Clinical Value and Utility of CGM Systems: Issues and Recommendations
Authors: Petrie John R. , Peters Anne L. , Bergenstal Richard M. , Holl Reinhard W. , Fleming G. Alexander , Heinemann Lutz
Published: October 2017

The first systems for continuous glucose monitoring (CGM) became available over 15 years ago. Many then believed CGM would revolutionize the use of intensive insulin therapy in diabetes; however, progress toward that vision has been gradual. Although increasing, the proportion of individuals using CGM rather than conventional systems for self-monitoring of blood glucose on a daily basis is still low in most parts of the world. Barriers to uptake include cost, measurement reliability (particularly with earlier-generation systems), human factors issues, lack of a standardized format for displaying results, and uncertainty on how best to use CGM data to make therapeutic decisions. This Scientific Statement makes recommendations for systemic improvements in clinical use and regulatory (pre- and postmarketing) handling of CGM devices. The aim is to improve safety and efficacy in order to support the advancement of the technology in achieving its potential to improve quality of life and health outcomes for more people with diabetes.
Influences on Diabetes Self-Management Education Participation in a Low-Income, Spanish-Speaking, Latino Population
Authors: Testerman Jill , Chase Dian
Published: October 2017

Objective.

To investigate influences on participation in diabetes self-management education (DSME) classes in a low-income, Spanish-speaking, Latino population.

Methods.

Fifteen patients from an Oregon clinic participated in semi-structured interviews designed to understand influences on their participation in DSME classes, and the authors conducted a thematic analysis.

Results.

Four themes characterized the data: 1) limited resources, 2) culture, 3) relationship with diabetes, and 4) relationship with clinic. Barriers to class attendance included lack of time, childcare, and transportation; male participants’ shame of illness and lack of interest in health; and difficulty contacting participants by telephone. Motivators of class attendance included interest in being healthy for the sake of family; interest in nutrition; knowledge of the effects of diabetes on self, friends, and family; and positive experiences with group support and self-efficacy in class.

Practice implications and conclusion.

Participation in DSME classes in this low-income, Spanish-speaking, Latino population was influenced by many factors. Understanding these factors is an important step toward creating classes that are successful in increasing attendance rates for this and similar populations. Creative, targeted approaches to designing DSME classes for low-income, Spanish-speaking, Latino patients and similar populations are needed. These may include classes that remove the barriers of shame and lack of interest for male participants; focus on family involvement, celebration of culturally appropriate foods, group support, and self-efficacy; are accessible to resource-limited participants; and use alternative methods to recruit hard-to-reach participants.
Estado, individuo e identidad
Authors: Arrúa Néstor Nicolás
Published: October 2017

El derrumbe del campo socialista y la reestructuración capitalista del trabajo consolidó la emergencia del neoliberalismo a escala mundial apoyado en la caída de los grandes relatos de la modernidad, que concebían sujetos de la historia hacia una meta de progreso cultural y económico. El neoliberalismo produjo reformas laborales y productivas que desencadenaron un redimensionamiento del mapa demográfico y económico mundial, con consecuencias de desplazamientos masivos de poblaciones ante la guerra y la penuria económica. Esto pone en jaque a los Estados nacionales que deben atravesar procesos de desterritorialización/territorialización de diversos sectores de su población, afectando las concepciones de ciudadanía y democracia dominantes en dichas sociedades.

El individuo deseado por las políticas e ideologías neoliberales como autosufi ciente y dueño de sí mismo, repercute en la conformación de políticas dirigidas a atender la cuestión social, bajo una perspectiva ligada al empoderamiento y el emprendedorismo. Estas se encuentran atravesadas por procesos combinados de explotación del trabajo en las sociedades periféricas, que transforman las identidades colectivas y formas de protesta en la coyuntura actual. De esta manera, ante un individuo autoabastecido, conminado al consumo y el placer, la construcción de lo colectivo está a la orden del día.

Palabras claves: Neoliberalismo - individuo - identidad- Estado - Ideología
1925: El sacrificio de José Ingenieros
Authors: García Germán
Published: October 2017

José Ingenieros nació el 24 de abril de 1877 y murió el 31 de octubre de 1925. La revista Nosotros dedica un número extraordinario (diciembre de 1925) donde se analiza y se exalta la figura del Maestro al que se le reconoce el mérito de haber producido ideales capaces de enlazar las generaciones venideras. Su muerte aparece como un sacrificio cuyos ofi iantes y beneficiarios son los representados por el discurso de la universidad: “En el cementerio del Oeste -relata Nosotros- inició la serie de los discursos el Ministro de Instrucción Pública, doctor Antonio Sagarna. Después de él hablaron: el profesor Nerio Rojas, en representación de la Universidad de Filosofía y Letras; el doctor Carlos Sánchez Viamonte, en nombre de los consejeros estudiantiles de la Facultad de Derecho; nuestro director Roberto F. Giusti, como delegado de la generación que en el año 18 inició en Córdoba la reforma universitaria; Arturo Orzábal Quintana, en representación de la Unión Latino Americana; el ministro de México, doctor C. Trejo Lerdo de Tejada; Vicente A. Fiori, por el Centro de Estudiantes de Medicina y Círculo Médico Argentino; Julio R. Barcos, en nombre de los maestros y Pedro Alcántara Tossi en el de la juventud brasileña”.
Brief Review of Educational Applications Using Data Mining and Machine Learning
Authors: Urbina Nájera Argelia Berenice , De la Calleja Mora Jorge
Published: October 2017

The large amounts of data used nowadays have motivated research and development in different disciplines in order to extract useful information with a view to analyzing it to solve difficult problems. Data mining and machine learning are two computing disciplines that enable analysis of huge data sets in an automated manner. In this paper, we give an overview of several applications using these disciplines in education, particularly those that use some of the most successful methods in the machine learning community, such as artificial neural networks, decision trees, Bayesian learning and instance-based methods. Although these two areas of artificial intelligence have been applied in many real-world problems in different fields, such as astronomy, medicine, and robotics, their application in education is relatively new. The search was performed mainly on databases such as EBSCO, Elsevier, Google Scholar, IEEEXplore and ACM. We hope to provide a useful resource for the education community by presenting this review of approaches.
Evaluación de la competencia digital docente en la Comunidad Autónoma de Aragón
Authors: Falcó Boudet José María
Published: October 2017

El presente artículo describe y analiza el nivel de la competencia digital docente en el profesorado de enseñanza media de la comunidad autónoma de Aragón (España). Se parte de los estándares fijados por organizaciones internacionales y por el Ministerio de Educación español para definir las dimensiones que la forman y para fijar los dos componentes que se estudian: conocimiento técnico y aplicación didáctica. Los datos se recogieron mediante un cuestionario diseñado con este propósito. Los resultados muestran que los profesores reconocen la aportación que las TIC pueden hacer al proceso de enseñanza-aprendizaje pero que, aunque tienen un nivel de desempeño medio para uso personal (búsqueda de información, utilización de herramientas más comunes), tienen un nivel bajo en el aprovechamiento didáctico. Los resultados evidencian la necesidad de fortalecer la formación inicial de los docentes y promover programas de formación permanente para el desarrollo de esta competencia.
Functional Classification of Skinning Injury Responsive Genes in Storage Roots of Sweetpotato
Authors: Effendy Jollanda , Efendi Darda , Khumaida Nurul , Wattimena And Gustaaf Adolf
Published: October 2017

Skinning injury in sweetpotato due to loss of skin or periderm which occurred during harvest is inevitable and account for financial loss due to dehydration, pests, and pathogens. Hence, studies on gene expression changed due to skinning injury can provide important information about this protective tissue and for improving the life of storage roots. New candidate genes involved in skinning injury were isolated with an Annealing Control Primer (ACP). Using 20 ACP primers, a total of 103 differentially expressed genes (DEGs) were retrieved. In this study, the functional annotation of these selected 15 up-regulated DEGs (10 contigs and 5 singletons) were characterized. The results showed that these 15 “DEG-unigenes” are mainly associated with defense and stress responses, regulation and signaling, protein synthesis and fate, and metabolism may play an important role in the primary responses to skinning injury in storage roots of sweetpotato. This study showed the importance of defense and stress responses genes to the formation of wound periderm. Furthermore, this results can be used for better understanding of the molecular mechanism of skinning/mechanical injury-related genes in the storage roots of sweetpotato as well as to all stems, fruits, and roots of all plants. Keywords: differentially expressed gene, gene function, Ipomoea batatas, wounding
Pemilihan Karakter Agronomi untuk Seleksi pada Galur-galur Padi Dihaploid Hasil Kultur Antera
Authors: Akhmadi Gerland , Purwoko Bambang Sapta , Dewi Iswari Saraswati , Wirnas Dan Desta
Published: October 2017

Anther culture technique is able to accelerate plant breeding activities. The objectives of this research was to determine the agronomic traits that could be used for selection of the dihaploid rice line population through the calculation of heritability, genotypic correlation, path analysis and selecting dihaploid rice lines. The plant material used was 65 dihaploid rice lines DH 1 of F1 anther culture plants and Ciherang and Inpari 13 as check varieties. Agronomic characters that could be used as selection character are generative plant height, number of filled grain per panicle, the total number of grains per panicle, weight of 1,000 grains, and grain per hill. Twenty three dihaploid lines were selected based good agronomic characters with criteria generative plant height between 80-120 cm, number of filled grains per panicle > 100, number of grains per panicle > 120, weight of 1,000 grains > 20 g, and grain per hill > 25 g.Keywords: anther culture, heritability, agronomic characters
Long-Term Omalizumab use in the Treatment of Exercise-Induced Anaphylaxis
Authors: Peterson Mark R. , Coop Christopher A.
Published: October 2017

Reported is a case of a 39-year-old male who was diagnosed with exercise-induced anaphylaxis (EIA). He was initially treated prophylactically with fexofenadine, montelukast, and ranitidine. He also used an epinephrine autoinjector as needed. He was refractory to these medications and continued to have episodes of EIA. He was then started on a trial of omalizumab, an immunoglobulin E monoclonal antibody, and had resolution of the EIA episodes. After discontinuation of the omalizumab, the EIA episodes returned. He was restarted on omalizumab and since that time, has had 5 years free of EIA episodes and can now exercise without any symptoms. To our knowledge, this is only the third case in the literature of successful treatment of EIA by using omalizumab. This case was unique because it provided successful long-term use of omalizumab for EIA. Further studies are recommended for the use of omalizumab in the treatment of EIA.
The Study of a Possible Correlation between Serum Levels of Interleukin 17 and Clinical Severity in Patients with Allergic Rhinitis
Authors: Aly Mai Aly Gharib , El Tabbakh Mohamed Tawfik , Heissam Waheed Fawzy , Abbadi Said Hamed
Published: October 2017

Introduction

Allergic rhinitis (AR) is one of the most common allergic diseases, which affects ~20% of the world's population. T-helper (Th) type 2 cells produce interleukin (IL) 4 and IL-13, and mediate allergic responses, and these cytokines have been extensively studied as key players in the atopic airway diseases. However, the involvement of Th17 cells and IL-17 in AR has not been clearly examined.

Aim

To reevaluate AR clinical severity with serum IL-17, whether IL-17 affects the disease alone or in contribution with the atopic predisposition.

Patients and Methods

During an 18-month period, 39 individuals were divided into three groups: A, (13 control), B (13 with mild-to-moderate AR), and C (13 with severe AR). Both group B and group C patients (26) were subjected to clinical examination and allergy skin testing, and to measurement of both total serum immunoglobulin E (IgE) and IL-17 levels. Eleven patients with AR then were exposed to 6 months of cluster immunotherapy, whereas the rest of the patients were not exposed.

Results

Revealed a significant elevation of serum IL-17 levels with an associated increase in serum IgE in the patients with AR compared with controls and revealed that the serum levels of both total serum IgE and IL-17 decreased significantly after cluster immunotherapy.

Conclusion

These preliminary results added new data about the use of injective immunotherapy as well as reported on the use of sublingual immunotherapy.
Long-term follow-up of a Patient with Malignant Transformation of Inverted Papilloma into Sinonasal Undifferentiated Carcinoma
Authors: Orgain Carolyn A. , Shibuya Terry Y. , Thompson Lester D. , Keschner David B. , Garg Rohit , Lee Jivianne T.
Published: October 2017

Introduction

Inverted papillomas (IP) are benign sinonasal neoplasms, which account for 0.5–4% of all nasal tumors. IPs have been known to transform into squamous cell carcinoma in 5–15% of cases. Rarely, transformations to other malignancies have been reported. Here we report a unique case of malignant transformation of an IP into sinonasal undifferentiated carcinoma (SNUC).

Methods

A case report with a literature review; institutional review board exempted. The clinical presentation, radiographic features, surgical intervention, histopathologic analysis, treatment, and outcome of the case were examined.

Results

A 62-year-old man presented with a 3-month history of nasal airway obstruction, rhinorrhea, and postnasal drip refractory to medical therapy. He had a long history of exposure to fumes, chemicals, dusts, and solvents as a professional painter as well as a 45 pack-year history of smoking and alcohol abuse. The patient was ultimately found to have a left ethmoidal IP with a focus of malignant transformation into SNUC. Endoscopic resection was performed, followed by concurrent chemoradiation and adjuvant chemotherapy. After surgery, he had no evidence of recurrent disease after 9 years of follow-up.

Conclusions

IP is known to transform into squamous cell carcinoma. Here we report a rare case of malignant transformation into SNUC, a much more uncommon and aggressive lesion. Although traditionally associated with a poorer prognosis, the positive outcome for SNUC observed in this patient may potentially be attributed to early detection and timely therapeutic intervention.
Multiple Doses of Icatibant used during Pregnancy
Authors: Kaminsky Lauren W. , Kelbel Theodore , Ansary Fay , Craig Timothy
Published: October 2017

Background

Hereditary angioedema (HAE) is a life-long disease that often manifests by puberty. Treatment of attacks is essential to improve quality of life and to decrease morbidity and mortality. During pregnancy, treatment is limited because multiple treatment options, including icatibant, are not approved for use during pregnancy.

Objective

We report the outcomes of three pregnancies during which icatibant was used by a patient with HAE with normal C1-inhibitor for treatment of attacks. We also reviewed the literature for reports of icatibant use during pregnancy for outcomes and adverse events.

Methods

We report on a patient who treated herself with icatibant during three separate pregnancies. Postpartum follow-up verified the health of the mother and children. We also performed a complete literature search of medical literature data bases on icatibant use during pregnancy.

Results

The patient in our report administered multiple doses of icatibant during three pregnancies. The child born from the first pregnancy and the child from the third pregnancy were born at term and without congenital anomalies. The child from the second pregnancy was 1-month preterm. All three children were developmentally normal. The literature search identified two case reports and one abstract of limited icatibant use without adverse events during pregnancy in patients with HAE. These pregnancies resulted in the births of healthy infants.

Conclusion

From a search of the literature, three cases of icatibant use during pregnancy resulted in healthy infants. In addition, we report that from icatibant use in three separate pregnancies, one infant was born prematurely, but there were no birth defects. From follow-up, the children continued meeting developmental milestones. This report adds to the acquisition of knowledge for drug adverse events during postmarketing surveillance for icatibant use during pregnancy.
Prenatal Maternal Depression Related to Allergic Rhinoconjunctivitis in the first 5 Years of Life in Children of the EDEN Mother-Child Cohort Study
Authors: Zhou Cailiang , Ibanez Gladys , Miramont Vincent , Steinecker Magali , Baiz Nour , Banerjee Soutrik , Just Jocelyne , Annesi-Maesano Isabella , Chastang Julie ,   EDEN Mother-Child Cohort Study Group, Charles Marie Aline , de Agostini Maria , Forhan Anne , Heude Barbara , Ducimetère Pierre , Kaminski Monique , Saurel-Cubizolles Marie-Josèphe , Dargent-Molina Partricia , Fritel Xavier , Larroque Beatrice , Lelong Nathalie , Marchand Laetitia , Nabet Cathy , Annesi-Maesano Isabella , Slama Remy , Goua Valŕie , Nlagnin Guillaume , Hankard Régis , Thiebaugeorges Olivier , Schweitzer Michel , Foliguet Bernard , Job-Spira Nadine
Published: October 2017

Backgroud

Evidence about the relationship between prenatal maternal depression and the development of childhood asthma and allergies in early life is scarce. We aimed to examine this relationship by using data set of EDEN mother-child cohort study. A total of 1139 children were followed-up until the age of 5 years.

Methods

Prenatal maternal depression was self-reported by using the Centre for Epidemiological Studies-Depression scale (CES-D) questionnaire and was classified into binary variable (maternal depression [CES-D score of≥16] and no maternal depression [CES-D score of <16]). Asthma and allergies in the first 5 years were assessed by using the questionnaire of the International Study of Asthma and Allergies in Childhood (ISAAC). Adjusted odds ratio (aOR) was estimated for the relationship between prenatal maternal depression and early life asthma and allergies by marginal models through the method of generalized estimating equation (GEE) when adjusting for the confounders.

Results

In our study population, 13.67 % of the mothers had clinical significant depression (the total scores for CES-D ≥16) during pregnancy. For children ages 5 years, the prevalence of wheezing, physician-diagnosed asthma, physician-diagnosed eczema and allergic rhinoconjunctivitis were 46.78, 20.99, 29.17, and 22.54%, respectively. Prenatal maternal depression was associated with ever allergic rhinoconjunctivitis (aOR 1.87 [95% confidence interval {CI}, 1.33–2.62]). No significant relationships were found between prenatal maternal depression and wheezing, physician-diagnosed asthma and physician-diagnosed eczema (aOR 1.12 [95% CI, 0.91–1.39], aOR 1.23 [95% CI, 0.81–1.85] and aOR 1.17 [95% CI, 0.86–1.61], respecitvely).

Conclusion

Prenatal maternal depression was related to ever allergic rhinoconjunctivitis in the first 5 years of life in children of EDEN mother-child cohort study.
An Ergonomic Assessment of Operating Table and Surgical Stool Heights for Seated Otolaryngology Procedures
Authors: Azimuddin Anam F. , Weitzel Erik K. , McMains Kevin C. , Chen Philip G.
Published: October 2017

Background

Musculoskeletal injuries, such as neck and back pain, during a surgeon's career are common. However, studies on ergonomics are limited with regard to seated otolaryngologic procedures. Key elements of an ergonomic operating environment include the height of operating tables and surgical chairs. Surgeons benefit from proper support and positioning to prevent musculoskeletal injuries and reduce occupational risk.

Objective

The purpose of this study was to evaluate operating table and surgical seat heights, and determine whether adjustments can be made for various surgeon physiques.

Methods

Operating tables and surgical seat dimensions were measured at local hospitals, and the information was complemented by an online search of other models.

Results

Five unique operating tables and five unique surgical stools were identified, both in the local hospital and in a search on the Internet. Of available tables, the greatest range was 63.5–124.5 cm, which reaches above the maximum suggested working height of 76.2 cm. The surgical stool with the widest range was adjustable from heights of 50.8–72.4 cm. This combination of operative table and surgical stool provided the greatest range of heights.

Conclusion

Of the available tables and stools measured, the combination of surgical table with a range of 63.5–125.7 cm and surgical stool with a range of 50.8–72.4 cm provided the greatest versatility for diverse physician heights. In ergonomic terms, this combination may reduce physical fatigue and create a potentially safer working environment for seated surgeons.
A Multicenter, Prospective, Noninterventional Study in a Norwegian Cohort of Patients with Moderate-to-Severe Allergic Rhinitis Treated with MP-AzeFlu
Authors: Dollner Ralph , Larsen Petter Lorentz , Dheyauldeen Sinan , Steinsvåg Sverre
Published: October 2017

Background

Allergic Rhinitis and its Impact on Asthma guidelines recently recommended a treatment strategy for allergic rhinitis (AR) based on disease control rather than symptom severity by using a visual analog scale (VAS) to categorize control

Objectives

To evaluate the effectiveness of MP-AzeFlu (Dymista®) by using this VAS in routine clinical practice in Norway. MP-AzeFlu comprises a novel formulation that contains azelastine hydrochloride, fluticasone propionate and excipients delivered in a single spray.

Methods

This multicenter, prospective, noninterventional study enrolled patients (n = 160) with moderate-to-severe AR and acute symptoms who were eligible to receive treatment with MP-AzeFlu according to its summary of product characteristics. Patients assessed symptom severity by using a VAS from 0 (not at all bothersome) to 100 mm (very bothersome) in the morning before MP-AzeFlu use on days 0, 1, 3, 7, and after ~14 days. On day 3, the patients assessed their level of disease control as well controlled, partly controlled, or uncontrolled. The proportion of Norwegian patients who achieved defined VAS score cutoffs for “well-controlled” and “partly controlled” AR were also calculated.

Results

MP-AzeFlu reduced the mean ± standard deviation VAS score from 68.1 ± 16.4 mm at baseline to 37.4 ± 25.9 mm on the last day, a reduction of 30.8 ± 27.2 mm. The results were consistent, irrespective of disease severity, phenotype (i.e., seasonal AR [SAR], perennial AR [PAR], SAR plus PAR, unknown) or age (i.e., 12–17, 18–65, and >65 years). Of the patients (with recorded data), 88.1% considered their symptoms to be partly or well controlled at day 3; and 19.5, 32.0, 50.0, and 61.0% of the patients achieved a ≤38 mm well-controlled VAS score cutoff on days 1, 3, 7, and the last day, respectively.

Conclusions

MP-AzeFlu provided rapid sustained symptom control in a routine clinical practice in Norway, which provided support for its effectiveness for the treatment of AR in real life.
El cuidado del amigo en la palabra y el silencio. El caso de Alipio
Authors: Magnavacca Silvia
Published: October 2017

Este breve trabajo se articula en tres partes: en la primera, y sobre la base de recientes trabajos sobre la ética medieval de los peccata oris, la autora se extiende sobre los extremos del multiloquium y la taciturnitas, con las respectivas caracterizaciones que de ellos hicieron los autores medievales y sus inmediatos antecedentes. Ubica, entonces, el uso sabio del officium locutionis entre esos extremos. En la segunda, se plantea la tradición ciceroniana sobre el concepto de amistad y su asunción y particular enriquecimiento por parte de Agustín. En la tercera parte hace confluir las consideraciones del arte de la palabra en el ejercicio de la amistad mostrando cómo Agustín concibe de hecho dicho arte en Confesiones VIII a propósito de su relación con Alipio.
El debate sobre la pluralidad de ideas divinas. La última enseñanza de Tomás de Aquino
Authors: Herrera Juan José
Published: October 2017

Durante el siglo XX algunos estudiosos de Tomás de Aquino sostuvieron que existe solamente una idea divina. La pluralidad de ideas les resultaba inconciliable con la absoluta simplicidad de Dios. Pero otros mostraron que la tesis original del Aquinate consistía en afirmar múltiples ideas en la mente divina. De hecho así lo expresan varios pasajes de sus obras. En esta oportunidad deseamos complementar la polémica contemporánea con el Quodlibet, IV, q. 1 de santo Tomás. Este breve texto, poco conocido y cuya traducción castellana ofrecemos, contiene la última enseñanza del teólogo dominico sobre la pluralidad de ideas divinas, por lo cual debería ser ponderado en cualquier discusión al respecto. Promover la lectura directa de esta fuente medieval es el principal objetivo de nuestro trabajo.
La cuestión De aeternitate mundi en Averroes y los averroístas
Authors: Herraiz Oliva Pilar
Published: October 2017

En el siglo XIII, en la Facultad de Artes de la Universidad de París, surge el averroísmo como movimiento filosófico que defiende la autonomía de la filosofía y de la razón. Una de las polémicas más relevantes en este período es la que tiene que ver con el origen del mundo, cuestión que ya tratara Averroes y que tiene de fondo la propia concepción de la realidad. En este artículo desarrollaremos las distintas posiciones de los autores más relevantes de este movimiento con respecto a la tesis sobre la eternidad del mundo y cuestionaremos la existencia de una posición unánime en torno a la misma que pueda ser considerada averroísta como tal.
La reflexión de Bartolomé de Albornoz sobre los Mercaderes y su trabajo
Authors: Perpere Viñuales Álvaro
Published: October 2017

En este artículo me centro en el desarrollo que hace Bartolomé de Albornoz al tratar sobre los mercaderes y su actividad. En su obra Arte de los Contractos (1573), su reflexión sobre los contratos no se limita al análisis jurídico, sino que también abarca a las implicaciones económicas, morales y sociales. En su análisis del comercio Albornoz señala que esta actividad es buena tanto en un sentido moral como en un sentido social. Para él, los mercaderes, es decir, aquellos que específicamente hacen del comercio su forma de vida, deben ser considerados personas muy importantes en sus sociedades, ya que con su trabajo que no sólo reciben dinero para ellos, sino que también crean bienestar y permiten a otras personas vivir mejor. Al mismo tiempo, desde una perspectiva moral, Albornoz afirma que esta actividad no tiene en sí ninguna maldad intrínseca. Por último, en este enfoque filosófico de los mercaderes y su trabajo, que implica tanto el aspecto moral social de la actividad comercial, es útil para entender las diferencias de desarrollo que se puede observar entre las diferentes sociedades. En opinión de Albornoz, el bienestar de las ciudades y reinos está atada esta consideración acerca de la bondad o maldad,tanto social como moralmente hablando, que se da a esta trabajo, y no a la posesión de oro o tesoros. La verdadera prosperidad surge para él en aquellos lugares donde los mercaderes reciben la honra que merecen.
Drugs from the Oceans: Marine Natural Products as Leads for Drug Discovery
Authors: Altmann Karl-Heinz
Published: October 2017

The marine environment harbors a vast number of species that are the source of a wide array of structurally diverse bioactive secondary metabolites. At this point in time, roughly 27'000 marine natural products are known, of which eight are (were) at the origin of seven marketed drugs,
mostly for the treatment of cancer. The majority of these drugs and also of drug candidates currently undergoing clinical evaluation (excluding antibody–drug conjugates) are unmodified natural products, but synthetic chemistry has played a central role in the discovery and/or development
of all but one of the approved marine-derived drugs. More than 1000 new marine natural products have been isolated per year over the last decade, but the pool of new and unique structures is far from exhausted. To fully leverage the potential offered by the structural diversity of marine-produced
secondary metabolites for drug discovery will require their broad assessment for different bioactivities and the productive interplay between new fermentation technologies, synthetic organic chemistry, and medicinal chemistry, in order to secure compound supply and enable lead optimization.
Discovery of Potent and Selective p53-MDM2 Protein–Protein Interaction Inhibitors as Anticancer Drugs
Authors: Holzer Philipp
Published: October 2017

As a result of our persistent efforts to discover novel inhibitors of the p53-MDM2 protein–protein interaction useful for the treatment of cancer, the potent and selective MDM2 inhibitors NVP-CGM097 and NVP-HDM201 with excellent in vitro and in vivo profile were
selected as clinical candidates and are currently in phase 1 clinical development. This short review article provides a summary of the program history, the applied pharmacophore model and the discovery story of these novel p53-MDM2 inhibitor investigational drugs.
Quadros superiores: agentes estratégicos de desenvolvimento das empresas
Authors: Cordeiro João Pina
Published: October 2017

Esta comunicação pretende refletir sobre os quadros superiores (QS) enquanto agentes estratégicos de desenvolvimento das empresas. A partir desta abordagem poder-se-á, por um lado, compreender melhor a importância das funções e, por inerência, dos saberes e/ou das competências dos QS na atualidade, por outro lado, responder à questão: de que falamos quando nos referimos a QS? As técnicas de investigação utilizadas foram a análise documental e o inquérito por questionário. A amostra é constituída por 72 empresas do setor de componentes para automóvel. Estruturalmente, faz-se uma reflexão teórica baseada na análise das propostas de objetivação e representação dos quadros em Portugal (Classificação Nacional das Profissões e Estruturas Sindicais Representativas) e na análise dos quadros como constructo dos modos de gestão das organizações. Empiricamente analisam-se as funções dos QS à luz dos resultados do inquérito por questionário aplicado às empresas do setor de componentes para automóvel. Conclui-se que os QS das empresas do setor de componentes para automóvel representam uma fonte de vantagem competitiva para as organizações. As funções, as competências e a possibilidade de identificar procedimentos adequados às diretrizes estratégicas das empresas são, entre outros, fundamentos de prestígio social associado aos QS no setor de componentes para automóvel.