bluuebunny/crossref_metadata_2025 huggingface dataset:
Criptococose e pombos urbanos (Columba livia
): uma reflexão social, ambiental e de políticas públicas
Authors: Ribeiro Charles Lima
Published: June 2019

A criptococose é uma micose sistêmica provocada principalmente por Cryptococcus neoformans; através do cosmopolitismo desse fungo, possui nos pombos urbanos (Columba livia) seu principal hospedeiro assintomático que, por ora, é um bioindicador negativo de qualidade ambiental. Este estudo possuiu caráter descritivo e realizou um levantamento em diferentes bases de dados- LILACS, Pubmed, Scielo-, com o intuito de relacionar a incidência de criptococose, a ocorrência de pombos urbanos com os aspectos de Vigilância em Saúde Ambiental e políticas públicas de enfrentamento a esse agravo. Com notificação não compulsória, não há dados concretos acerca da incidência de tal fungemia; portanto, dentre os mecanismos de controle do principal agente transmissor, que são os pombos urbanos, há os processos educativos, são os mais efetivos, tais que colaboram na elaboração de políticas públicas eficazes e mitigadoras, além de precaver a necessidade de mudança na perspectiva socioambiental tanto para a sociedade quanto para o poder público.
Adição de farinha de jenipapo em cookie
 altera a composição físico-química e a aceitabilidade sensorial entre crianças
Authors: Butke Wleizieli , Amaral Luane Aparecida do , Santos Elisvânia Freitas dos , Novello Daiana
Published: June 2019

O objetivo do estudo foi avaliar a aceitabilidade sensorial de cookie adicionado de Farinha de Jenipapo (FJ). Também, determinar a composição físico-química da formulação padrão e daquela contendo maior teor de FJ e com aceitação semelhante ao padrão. Foram desenvolvidas 6 formulações de cookie: F1 (padrão, 0% de FJ) e as demais adicionadas de 3,5% (F2), 5% (F3), 6,5% (F4), 8% (F5) e 9,5% (F6) de FJ. Participaram da avaliação sensorial 70 julgadores não treinados de 7 a 10 anos. A amostra padrão apresentou maior aceitabilidade sensorial (p<0,05) que F6. As demais formulações não tiveram diferença significativa entre si (p>0,05). Maiores teores de cinzas e fibra alimentar, menores de umidade e lipídio e semelhantes de proteína, carboidrato e calorias foram verificados em F5. Conclui-se que um nível de adição de até 8% de FJ em cookie é bem aceito pelas crianças, obtendo-se boas expectativas de comercialização. Além disso, melhora o valor nutricional do produto, especialmente com o aumento no teor de minerais e de fibra alimentar.
BACK-REFERRAL PROGRAM IN THE ERA OF NATIONAL HEALTH INSURANCE AT BALUNG DISTRICT GENERAL HOSPITAL OF JEMBER IN 2017
Authors: Sandra Christyana
Published: June 2019

Background: In 2014, National Health Insurance Program (BPJS Kesehatan) implemented Back-Referral Program (BRP) to facilitate access to health care for patients with chronic diseases in stable conditions. However, the program did not run well at District General Hospital of Balung which had the lowest back-referral program (6 participants) in 2015-2016.Aim: The study aims to examine the BRP at Balung District General Hospital of Jember in 2017.Methods: This study is designed as qualitative case study. The informants consisted of head of treasury verification, secretary of JKN service controlling, officers of local government’s free care scheme, coordinator of internal and neurological disease, specialists in internal and neurological diseases, officers of Social Security Agency for Health, officers of patient eligibility verification, and participants of Back-Referral Program. The study was conducted from October to December 2017.Results: Results show that the attendance of BPJS Kesehatan officers has no contribution to the services of BPJS Kesehatan in the hospital. Participants also find it difficult to follow the steps of BRP due to unavailability of drugs at primary healthcare centers. Moreover, neurologists have not written any referral recommendation since 2016, so there was no patient admittance.Conclusions: The BRP at Balung District General Hospital did not achieve its target (<5 cases/week). In the contrary, the average number of patients referred to the hospital was 86 patients per week. Balung District General Hospital should implement Standard Operating Procedure for letters signed by responsible physician for patients and evaluate the BRP. Keywords: National Health Insurance, Back-referral program, Hospital, Social security.
IMPROVING THE PERFORMANCE OF PRIMARY HEALTHCARE CENTERS IN SURABAYA: A COMPARISON OF LEADERSHIP STYLE AND VERTICAL DYAD LINKAGE
Authors: Soesanto Danoe
Published: June 2019

Background: Leadership style and Vertical Dyad Linkage have a significant influence on organization’s performance, especially public health service providers. Leadership style is one factor that will influence the performance and management of primary healthcare center (PHC).Aim: This study aims to investigate the influence of leadership style and leader-member exchange to the performance of PHC.Methods: The research is an observational study with a cross-sectional design. There were 27 PHCs involved in the study. Each PHC was represented by 11 respondents including the directors, five health program coordinators, and their five members. Data were collected with questionnaires and then analyzed using Multinomial Logistic Regression (α=0.05).Results: The results of the research show that (37.05%) of PHCs use supportive leadership style, and (33.33%) of them use participative leadership style. Most of the Vertical Dyad Linkage of PHC were imbalanced social overinvestment (40.7%), and the work performance showed enough performance (59.3%). Path-Goal leadership had the most influence on the performance of PHC.Conclusions: Excellent performance of PHC is related to achievement-oriented leadership style. Work performance of PHC can be improved by improving real neutral leader-member exchange. Furthermore, identifying employees’ maturity can be chosen as the leadership style. Employees’ self-esteem can be developed to improve the work performance of PHC. Keywords: Leadership style, Vertical Dyad Linkage, Performance of primary healthcare centre.
THE EQUITY OF ANTENATAL CARE STANDARD IN DIFFERENT AGES
Authors: Goemawati Efvina , Kristy Titis Widya
Published: June 2019

Background: Antenatal care standard ensures the health of pregnant woman with early detection of risk factors, prevention and treatment provided by competent health practitioners. Health equality does not always mean improving the same service for everyone, but the services are provided according to everyone's needs.Aim: This research was to examine the antenatal standards based on patients’ needs in the Public Health Centre of Medokan Ayu.Methods: This research was observational by using cross-sectional design. The population in this study was 518 pregnant women who gave birth from June 2011 to May 2012 in the Primary Healthcare Center of Medokan Ayu. There were 88 mothers as samples obtained by a cluster random sampling.Results: This study determines the need for antenatal care standards can be fulfilled more for the age of <20 years and >30 years to avoid the high risk of maternal death and needs and equity based on the standards. There were no differences in the acceptance standard of antenatal care (5T and 7T) based on the age group between <20 years, 20-30 years, and> 30 years.Conclusions: Reproductive women need to recognize the importance of antenatal care. The availability and quality of antenatal care need to be further maintained by the healthcare providers, and they need to be more aware to the importance of antenatal care. Women in later reproductive period need to be aware of the prevailing risks in circumstances. Keywords: Equity, Antenatal care standard, Age.
OPPORTUNITY LOSS ANALYSIS OF DISCHARGE AGAINST MEDICAL ADVICE (DAMA) AT INPATIENT UNIT OF TYPE A HOSPITAL IN SURABAYA
Authors: Bilqis Nabilah , Prakoso Seta
Published: June 2019

Background: Patients who Discharge Against Medical Advice (DAMA) will experience the opportunity loss. DAMA will result in opportunity loss for patients to get treatment and cure their illness. For hospitals, DAMA patients will cause the opportunity loss for hospitals to provide services to patients.Aim: The purpose of this research was to analyze the opportunity loss as the result of DAMA patient. Methods: The method used in this research was a descriptive research. The samples were chosen from the total sample of inpatient population who did DAMA as many as 77 medical records. The inclusive samples were doctors who were responsible for other doctors and dentists as well as inpatient medical records. Meanwhile, the exclusive samples were doctors who are not responsible for other doctors and dentists as well as inpatient medical records. Data analysis used Microsoft Excel to see the total and percentage of DAMA patients.Results: The number of DAMA patients was 77 patients. The highest number of DAMA patients was those in grade 3 as many as 25%. It happened because the grade 3 was cheaper than others. As many as 65% of DAMA patients paid hospital fees using general payments. Patients felt free to discharge themselves from the hospitals because they funded on their own. The majority of DAMA patients were type 2 DM patients amounted to 12% because they assumed they could carry out self-care at home.Conclusions: DAMA patients caused opportunity loss and no Social Security Agency for Health (BPJS Kesehatan) guarantees. Therefore, the hospital has to form a policy to prevent patients from DAMA, notify and ask patients’ reasons of doing DAMA, so the hospital can use these as information for hospital service evaluation. Keywords: Opportunity loss, DAMA, Hospital.
Effect of the Quintessential Dark Energy on Weak Deflection Angle by Kerr-Newmann Black Hole
Authors: Javed Wajiha , Abbas Jameela , Övgün Ali
Published: June 2019

In this work, we study the weak gravitational lensing in the background of Kerr-Newman black hole with quintessential dark energy. Initially, we compute the deflection angle of light by charged black hole with quintessential dark energy by utilizing the Gauss-Bonnet theorem. Firstly, we suppose the light rays on the equatorial plane in the axisymmetric spacetime. In doing so, we first find the corresponding optical metrics and then calculate the Gaussian optical curvature to utilize in Gauss-Bonnet theorem. Consequently, we calculate the deflection angle of light for rotating charged black hole with quintessence. Additionally, we also find the deflection angle of light for Kerr-Newman black hole with quintessential dark energy. In order to verify our results, we derive deflection angle by using null geodesic equations which reduces to the deflection angle of Kerr solution with the reduction of specific parameters. Furthermore, we analyze the graphical behavior of deflection angle $\Theta$ w.r.t to quintessence parameter $\alpha$, impact parameter $b$, BH charge $Q$ and rotation parameter $a$. Our graphical analysis retrieve various results regarding to the deflection angle by the Kerr-Newman black hole with quintessential dark energy.
Aplicación de un análisis clúster para el estudio de la segregación social en el municipio de Bilbao
Authors: Aguado Moralejo Itziar , Echebarria Miguel Carmen , Barrutia Legarreta José María
Published: June 2019

La segregación residencial es un hecho innegable en cualquier ciudad del mundo. Partiendo de la premisa de que la segregación es un proceso multidimensional, y de que el diagnóstico territorial es el primer paso para poder poner en marcha cualquier tipo de política, en este trabajo realizamos una caracterización y taxonomía de los barrios de Bilbao mediante un análisis clúster a partir del tratamiento y depuración de diferentes fuentes estadísticas: municipales, regionales y nacionales. Nuestro análisis sugiere que son las variables relacionadas con la renta y el estatus migratorio las que, fundamentalmente, condicionan dicha segregación. La identificación de las diferentes tipologías de barrios permitirá reorientar las políticas locales para tratar de dar solución a las áreas afectadas.
CD45+ Erythroid progenitor cell contribute to antiangiogenic drug resistance via regulating lipid metabolism in lymphoma
Authors: Wei Xia , Yang Sainan , Pu Xin , He Silian , Yang Zailin , Sheng Xiaomin , Jin Ling , Chen Wen , Zhang Yong
Published: June 2019

Background: More than half of lymphoma patients are complicated with anemia. Anemia often indicates a poor prognosis, but the mechanism is still unclear. Erythroid progenitor cells (EPCs) are precursors of erythrocytes and play an important role in maintaining the homeostasis of erythrocytes. Here we investigated the role and mechanism of EPCs in promoting lymphoma progression.

Methods: Ki-67, CD31, P-AMPK and CPT1A expression was detected by immunohistochemical staining. CD45+ EPCs were detected by flow cytometry. Animal experiments were used to detect the effect of CD45+ EPCs on lymphoma.

Results: Our study found that the proportion of CD45+ EPCs in anemic patients with diffuse large B-cell lymphoma (DLBCL) was significantly higher, which is positively correlated with the expressions of P-AMPK and CPT1A in lymphoma tissues. Interestingly, we found that in hypoxic conditions, CD45+ EPCs regulated lipid metabolism and enhanced energy metabolism of lymphoma cells through AMPK-ACC-CPT1A pathway, further promoted cell proliferation and inhibited apoptosis of lymphoma cells. Animal experiments showed that CD45+ EPCs combined transplantation significantly increased the resistance of antiangiogenic drugs. ROS played a key role in this process.

Conclusion: CD45+ EPCs contributed to antiangiogenic drug resistance via regulating lipid metabolism in lymphoma.
The Effect of Stress Management Training on Stigma and Social Phobia in HIV‐positive women
Authors: shamsaei Farshid , Tahour Neda , Sadeghian Efat
Published: June 2019

Objectives: This study was to investigate the effect of stress management training on the stigma and social phobia of HIV‐positive women.
Methods: This semi-experimental was conducted on 55 HIV‐positive using census sampling. The participants referred to Shohada Comprehensive Health Center in Hamadan, west of Iran, in 2017. Stress management training was conducted in 5 sessions for a group of 8-10 participants. The data collection tools were Berger HIV Stigma and Connor Social Phobia Scale. The questionnaires were filled before and 2 weeks after the intervention.
Results: The mean age of participants was 38.5 and the duration of HIV infection was 6.5 years. 55% of patients were married and 80% were infected by sexual intercourse. The findings showed that there was a significant difference between the mean scores of stigma and social phobia before and after the intervention (P<0.05).
Conclusions: Stress management training has been effective in the decrease of stigma and social phobia among HIV positive women.
Oxaliplatin resistance is enhanced by saracatinib via upregulation Wnt-ABCG1 signaling in hepatocellular carcinoma
Authors: Liao Xia , Song Ge , Xu Zihan , Bu Yang , Chang Fan , Jia Fengan , Xiao Xuelian , Ren Xuejiao , Zhang Mei , Jia Qingan
Published: June 2019

Background: Chemo-resistance in hepatocellular carcinoma (HCC) is a major problem, and acquired drug resistance prevents cancer therapies from achieving complete responses. Molecular targeting therapy presents an opportunity to impede tumor through combination or sequential therapy, while the accurate effect is vague.
Methods: The efficacy of combinations between oxaliplatin and anti-cancer molecular targeting drugs was screened. Strangely, the combined chemotherapy with oxaliplatin and saracatinib induced significantly antagonistic effects. Then the antitumor effects of combined treatment with saracatinib and oxaliplatin were confirmed in wide type HCC as well as in saracatinib- and oxaliplatin-resistant HCC. RNA sequencing was used to explore the resistance mechanism, and the roles of ABCG1 and Wnt signaling in oxaliplatin resistance were confirmed.
Results: Chemotherapy with oxaliplatin and saracatinib individually induced strong anti-HCC effects, while combined or sequential treatment of HCC cells with these two drugs exhibited reduced efficacy compared to treatment with the single drugs. And it was saracatinib treatment caused oxaliplatin resistance. RNA sequencing revealed 458 genes that were altered by treatment with saracatinib and oxaliplatin. Of these, the gene encoding the ATP-binding cassette transporter G1 ABCG1 and Wnt-associated genes were significantly upregulated. Upregulation of ABCG1 and oxaliplatin resistance were associated with activation of Wnt signaling. Interference with ABCG1 expression or inhibition of Wnt signaling resulted in reversal of the saracatinib-induced oxaliplatin resistance in HCC.
Conclusions: These studies demonstrated that combined or sequential chemotherapy with oxaliplatin and saracatinib reduced antitumor efficacy, and this antagonism was attributed to the activation of Wnt signaling and upregulation of ABCG1 by saracatinib.
Risk factors of primary open-angle glaucoma: the first case-control hospital-based study in Vietnam
Authors: Bui Anh Van , Hoang Tung Thanh , Nguyen Ngoc Bich , Le Anh Kim , Patnaik Jennifer L.
Published: June 2019

Purpose: To identify risk factors for primary open-angle glaucoma (POAG) in a Vietnamese population. Methods: A matched case-control study was conducted at Vietnam National Institute of Ophthalmology. Cases were patients clinically diagnosed with POAG. Controls were caregivers of patients with other eye diseases, free from any ocular and systemic abnormalities, and were selected and then matched with the cases by gender and age. Cases and controls were examined by a glaucoma specialist to confirm presence or absence of POAG. Data on demographic, ophthalmic and medical conditions were collected via interview at time of examination. Associations between POAG and potential factors were examined by univariate conditional logistic regression analysis (OR – Odd Ratios) and multivariate conditional logistic regression (AOR – Adjusted Odd Ratios) with level of significance is 0.05. Results: In total, 128 cases with POAG and 128 controls were recruited. Multivariate conditional (fixed-effects) logistic regression analysis resulted in several significant risk factors, including hypertension AOR =4.7 (95% CI: 1.8–12.0; p=0.002); family history of glaucoma AOR = 6.4 (95% CI: 1.3 – 32.2; p = 0.026); over–the–counter eye medication AOR = 3.1 (95% CI: 1.5 – 6.5; p = 0.006), and a protective role for marriage AOR = 0.2 (95% CI: 0.1 – 0.7; p = 0.006) and weekly exercise AOR = 0.3 (95% CI: 0.1 – 0.8; p = 0.021). Conclusions: Hypertension, family history of glaucoma and over–the–counter eye medication were risk factors while marriage and weekly exercise were protective factors for POAG in Vietnamese population.
Statistical analysis plan for Early mobilisation by head-up tilt with stepping versus standard care after severe traumatic brain injury – a randomised clinical feasibility trial
Authors: Riberholt Christian Gunge , Gluud Christian , Jakobsen Janus Christian , Ovesen Christian , Mehlsen Jesper , Møller Kirsten
Published: June 2019

Background: Early mobilisation on a tilt table with stepping versus standard care may be beneficial for patients with severe brain injury, but data from randomised clinical trials are lacking.

Methods: This statistical analysis plan describes the analyses of data collected in a randomised clinical feasibility trial for early mobilisation by head-up tilt with stepping versus standard care after severe traumatic brain injury. Primary feasibility outcomes are the proportion of included participants who were randomised out of all screened patients; the proportion of participants allocated to the experimental intervention who received at least 60% of the planned exercise sessions; and safety outcomes such as severe adverse events and reactions and adverse events and reactions. Exploratory clinical outcomes are suspected unexpected severe adverse reactions; and functional outcomes as assessed by Coma Recovery Scale – Revised at four weeks; Early Functional Ability Scale, and Functional Independence Measure at three months. Exploratory physiological outcomes are electrocardiographic data; mean arterial pressure; and middle cerebral artery blood flow velocity, all obtained during the head-up tilt test. From the first head-up tilt test and five days onwards, a heart rate was measured by continuous electrocardiography. The detailed description includes the statistical analysis including use of multiple imputation and Trial Sequential Analysis.

Conclusions: The present statistical analysis plan serves to minimise potential trial reporting bias and selective P hacking and to improve transparency. This feasibility trial will inform design and eventual launching of a larger multicentre randomised clinical trial.

Trial registration: ClinicalTrials.gov identifier: NCT02924649. Registered on 3 October 2016.
Applied prospect theory: assessing the βs of M&A-intensive firms
Authors: Ryan Homan Garth , van Vuuren Gary
Published: June 2019

Behavioral components of Kahneman and Tversky’s (1979) prospect theory (PT) were applied to derive an adjusted Capital Asset Pricing Model (CAPM) in the estimation of merger and acquisition-intensive firms’ expected returns. The premise was that the CAPM – rooted in expected utility theory – is violated by the behavioral biases identified in prospect theory. Kahneman and Tversky’s prospect theory (1979) has demonstrated that weaknesses abound in the viability of classical utility theory predictions. For mergers and acquisitions, firms appear to be isolated from and immune to human error, yet decisions which involve the undertaking of capital-intensive projects are delegated to senior management. These individuals are prone to cognitive biases and personalized risk appetites that may (and often do) compromize attitudes and behavior when it comes to pricing risky ventures. Having established that beta estimates using linear regression are inferior, the CAPM was implemented utilizing beta estimates obtained from the Kalman filter. The results obtained were assessed for their long-term market price predictive accuracy. The authors test the reliability of the CAPM as a predictor of price, observe the rationality of human behavior in capital markets, and attempt to model premiums to adjust CAPM returns to a level that more appropriately accounts for firm specific risk. The researchers show that market participants behave irrationally when assessing M&A firms’ specific risk. Logistic regression coupled with the development of a risk premium was implemented to correct the original Kalman filter returns and was tested for improvements in predictive power.
Bilateral Cochlear Otosclerosis; Clinic and Radiologic Findings
Authors: ÇANAKCI Hasan , BÜLBÜL Erdoğan
Published: June 2019

Otosclerosis
is a focal osseous dyscrasia of the temporal bone in human. It can be
categorized into 2 types: Fenestral and retrofenestral/cochlear,
depending on the topography of the lesions. According to the
involvement of disease different symptoms might be seen such as
conductive, sensorineural, or mixt type hearing loss. Altough the
certain diagnosis of disease is histopathologic investigation, high
resolution computed tomography (HRCT) is the gold standard imaging
modality in the diagnosis of otosclerosis. In this case, Forty-one
years old female patient who suffers from unilateral mixt type
hearing loss in her right ear was presented. Although there was only
traffic accident in the past there was no evidence of ossicle
dislocation and any disease that might cause conductive hearing loss
on HRCT imaging. Bilateral cochlear otosclerosis was observed on
HRCT. Her right ear was thought to be affected by cochlear
otosclerosis expanded to the lateral wall of the otic capsule that
had been caused a mixt type hearing loss in the right and a
sensorineural hearing loss in the left. We revealed incidentally
fenestral and cochlear type represented in continium in her right
ear.It is important to perform radiologic investigation to clarify
the concomitant pathologies in hearing loss.
Göğüs Cerrahisi Sonrası Erken Dönemde Uygulanan Fizyoterapinin Hemodinamik Etkileri
Authors: PEHLİVAN Esra , BALCI Arif , CAGAY Feride Elçin , ULUKOL Z. Nilgün
Published: June 2019

Amaç: Çalışmamızın amacı torokotomi sonrası yoğun bakım
ünitesinde yatmakta olan hastalarda erken dönemde uygulanan fizyoterapinin
hemodinamik etkilerinin belirlenmesidir.Gereç ve Yöntemler: Torokotomi yapılan ve cerrahi yoğun
bakımda 24 saatlerini tamamlayan hastalar çalışmaya dahil edildi. Hastalara
solunum egzersizleri, insentif spirometre çalışması, destekli öksürme ve
mobilizasyon içerikli fizyoterapi programı, cerrahi yoğun bakım ünitesinde
uygulandı. Hastaların tedavi öncesinde, sonrasında ve 5 dakika
toparlanmalarının ardından sistolik (SKB) ve diastolik kan basınçları (DKB),
kalp hızı (KH) ve oksijen saturasyonları (SpO2) kaydedildi. Ağrı seviyeleri ise vizüel analog
skalası (VAS, 0-10) kullanılarak değerlendirildi.Bulgular: Yirmiikisi (%30) kadın, 50 (%70)’si erkek, yaş ortalaması
59 olan 72 hasta çalışmaya alındı. 
Tedavi öncesi ve sonrası karşılaştırılmasında DKB’de yükselme (p=,006),
tedavi sonrası ve 5 dakika toparlanma karşılaştırılmasında KH’de düşme
(p=,008), tedavi öncesi ve 5 dakika toparlanma karşılaştırmasında ise KH’deki
düşme (p=,026) ve DKB’deki yükselme (p=,014) istatistiksel olarak anlamlıydı.
Meydana gelen hemodinamik değişimler fizyolojik limitler içindeydi.

Sonuç: Çalışmamızdan
elde edilen sonuçlara göre cerrahi yoğun bakım ünitesinde uygulanan erken dönem
fizyoterapi güvenlidir. Fizyolojik yanıtları gözlemlemek ve hasta güvenliğini
sağlamak amacıyla fizyoterapi sırasında hemodinamik parametreler sürekli
monitorize edilmelidir.
Natural Terpenoids as Neuroinflammatory Inhibitors in LPS-stimulated BV-2 Microglia
Authors: Xu Yuanzhen , Wei Hongbo , Gao Jinming
Published: June 2019

Neuroinflammation is a typical feature of many neurodegenerative diseases, including Alzheimer’s
disease and Parkinson’s disease. Microglia, the resident immune cells of the brain, readily
become activated in response to an infection or an injury. Uncontrolled and overactivated microglia
can release pro-inflammatory and cytotoxic factors and are the major culprits in neuroinflammation.
Hence, research on novel neuroinflammatory inhibitors is of paramount importance for the treatment
of neurodegenerative diseases. Bacterial lipopolysaccharide, widely used in the studies of brain inflammation,
initiates several major cellular activities that critically contribute to the pathogenesis of
neuroinflammation. This review will highlight the progress on terpenoids, an important and structurally
diverse group of natural compounds, as neuroinflammatory inhibitors in lipopolysaccharidestimulated
BV-2 microglial cells over the last 20 years.
Utilization of Tumor Markers in Adnexal Masses: A Review of Current Literature
Authors: Penick Emily , Olowu Victoria
Published: June 2019

Background:

Adnexal masses are a common presenting concern among women of all
age groups. While the majority of adnexal masses are benign, the differentiation of a mass and diagnosis
of malignancy can present a dilemma. The use of laboratory studies and tumor markers,
which can be obtained through minimally invasive means, can aid in the diagnosis of a mass or the
decision to refer a patient to a specialist.

Objective:

This review provides information on current available tumor markers, their use in the
diagnosis of various adnexal masses and tumors, a review on current biomarker panels, and the role
these results play in treating pre- and postmenopausal patients with adnexal masses.

Results:

Many tumor markers exist; however, the majority of markers are not specific to one tumor
or cancer. Many benign conditions also cause elevations in tumor markers, which can make distinguishing
benign and malignant conditions difficult. In recent years, the development of biomarker
panels has served to improve diagnostic accuracy when dealing with an adnexal mass and algorithms
have been developed to aid with triaging a patient to continued observation versus referral to
a specialist.

Conclusion:

It is important to merge clinical and laboratory data together when diagnosing and
managing any patient with an adnexal mass given the many benign and malignant conditions that
can cause elevations in tumor markers.
E200k Familial Creutzfeldt-Jakob Disease Presenting with Subacute Multiple Cranial Neuropathy
Authors: Lapucci C. , Romano N. , Boffa G. , Saitta L. , Nobili F. , Mancardi G.L. , Mandich P. , Grandis M.
Published: June 2019

Unusual clinical presentations in patients with E200K familial Creutzfeldt-Jakob Disease (fCJD) have been rarely reported. Herein, we described a case of E200K fCJD presenting with subacute cranial multiple neuropathy, initially suspected to be paraneoplastic or due to a leptomeningeal carcinomatosis, considering the neoplastic comorbidity of the patient. Surprisingly, brain MRI was highly suggestive of CJD. Brain histological examination confirmed the diagnosis. Genetic tests led to the definite diagnosis of E200K fCJD. To the best of our knowledge, the current case provides the first report of a histologically-confirmed E200K fCJD starting with cranial multiple neuropathy and may widen the spectrum of the clinical variability of CJD, also in its genetic variant. Unusual presentations may lead, as in this case, to incorrect diagnostic hypothesis and unuseful therapeutic attempts in the first phase of the diagnostic process. Also in the genetic variant of CJD, brain MRI demonstrated a very high sensitivity to detect the typical abnormalities since the earliest phases of the disease.
Virtual Eye Simulation: An Aid in Evaluation of Capsular Block Syndrome
Authors: Hu Joseph L. , Hu Chao-Chien
Published: June 2019

Objective:

To demonstrate the findings of three consecutive cases of postoperative Capsular Block Syndrome (CBS) diagnosed with the aid of Pentacam virtual eye simulation images.

Methods:

Observational case series report. Three patients underwent uneventful cataract removal and presented with blurry vision ranging from 4 days to 5 years after the surgeries were performed.

Results:

In a case of early-onset postoperative CBS, virtual eye simulation images clearly revealed a reduced posterior chamber depth caused by the accumulation of transparent fluid in the area between the intraocular lens and the posterior capsule. In two cases of late-onset postoperative CBS, virtual eye simulation images better visualized the alignment between intraocular lens (IOL) and iris than slit lamp examination and Schiemflug images. All three of the cases underwent neodymium-doped yttrium aluminum garnet (Nd:YAG) laser capsulotomy, and their capsular bag distensions were resolved immediately. The patients with misalignments between IOL and iris experienced more improvement in best-corrected visual acuity as opposed to the one who did not.

Conclusion:

Virtual eye simulation is found to be a useful way in visualizing misalignment between IOL and iris and assisting diagnoses of both early- and late-onset postoperative capsular block syndrome.
The Relationship between Nurses’ Recognition Regarding Elder Abuse and their Attitudes and Performance in Dealing with Elder Abuse Induced by Iranian Family Caregivers
Authors: Alipour Atefeh , Fotokian Zahra , Shamsalinia Abbas , Ghaffari Fatemeh , Hajiahmadi Mahmoud
Published: June 2019

Introduction:

Knowledge of nurses regarding elder abuse can be helpful in decisions about on-time and appropriate interventions. Our aim was to assess the relationship between recognition of nursing staff toward elder abuse and their attitudes, and performance in dealing with elder abuse induced by Iranian family caregivers.

Methods:

In this descriptive study, 400 nurses were selected, using cluster sampling, from nurses working in public or private hospitals in Iran. Data collection was performed using questionnaires measuring elder abuse symptom recognition, attitudes, and performance.

Results:

There is a significant relationship between the total scores for recognition of symptoms and elder abuse potential risk factors (p=0.05) and the nurses’ attitudes and performance scores (p = 0.001). There was no significant difference between the nurses’ performance and recognition scores (p = 0.14).

Conclusion:

Interventions to promote nurses’ recognitionviain-service educational programs can improve nurses’ performance in different levels of abuse prevention and the quality of nursing care for the elderly.
Harpin Proteins Improve Bioactive Compounds Content in Crimson Seedless Table Grape
Authors: Crupi Pasquale , Debiase Giambattista , Masi Gianvito , Mangione Francesca , Tarricone Luigi
Published: June 2019

Background:

Frequently, in warm climates such as Mediterranean areas, a red-pink table grape ‘Crimson Seedless’ does not reach a good berry skin color; and an acceptable anthocyanin bioactive compounds content, responsible for the red color of berries. Harpin proteins are biotechnologically developed bio-activators that, if applied on plants during the growing period, trigger the expression of hundreds of genes among which those associated with the biosynthesis of bioactive compounds (such as anthocyanins).

Aim:

This research aimed at using harpin proteins to test their suitability in improving the grape skin color.

Methods and Materials:

Beta-harpin protein 1% p.a. (400 g/Ha) was applied to ‘Crimson Seedless’ vines three times at the beginning of veraison. Six samplings were carried out for both the treated and control grapes until commercial harvest. In the skin extracts, total and individual anthocyanins content was determined by UV-Vis and RP-HPLC-DAD analyses, respectively.

Results:

The collected results confirmed that the application of harpin proteins effectively stimulated the anthocyanin biosynthesis leading to make peonidin-3O-glucoside, cyanidin-3O-glucoside, and malvidin-3O-glucoside values from 2 to almost 10 folds higher in treated grapes than in control grapes (P< 0.05).

Conclusion:

Actually, harpin proteins improved the color of the berry skin, leading to a significantly higher concentration of anthocyanins in treated than in control grapes.
Effect of empowerment and compensation on performance of honorary employees mediated by organizational commitments
Authors: Widyastuti Ni Putu Ayu , Riana I Gede
Published: June 2019

The purpose of this study to analyze the influence of empowerment and compensation on employee performance is mediated by organizational commitment. The study was conducted by distributing questionnaires to a sample of 100 honorary employees in regional organizations in Denpasar using the proportionate random sampling method. The analytical method used is Partial Least Square (PLS) analysis. The results of PLS ​​analysis show that empowerment, compensation, and organizational commitment have a positive and significant direct effect on employee performance. Finally, organizational commitment has a positive and significant effect on mediating empowerment and compensation for employee performance. The results of this study imply that empowerment and compensation are important factors in improving employee performance. In addition, the mediating role of organizational commitment can also contribute to improving performance. The management of each regional apparatus organization in Denpasar City needs to pay attention to these matters so that organizational goals can be achieved.
Using a Virtual Serious Game (Deusto-e-motion1.0) to Assess the Theory of Mind in Primary School Children: Observational Descriptive Study
Authors: Lázaro Esther , Amayra Imanol , López-Paz Juan Francisco , Martínez Oscar , Pérez Alvarez Manuel , Berrocoso Sarah , Al-Rashaida Mohammad , García Maitane , Luna Paula , Pérez-Núñez Paula , Rodriguez Alicia Aurora , Fernández Paula , Parada Fernández Pamela , Oliva-Macías Mireia
Published: June 2019

Background

Given the interactive media characteristics and intrinsically motivating appeal, virtual serious games are often praised for their potential for assessment and treatment.

Objective

This study aims to validate and develop normative data for a virtual serious game (Deusto-e-motion1.0) for the evaluation of emotional facial expression recognition and social skills, both of which are components of the theory of mind.

Methods

A total of 1236 children took part in the study. The children were classified by age (8-12 years old), gender (males=639, females=597), and educational level (between the third and sixth years of Primary Education). A total of 10 schools from the Basque Country and 20 trained evaluators participated in this study.

Results

Differences were found in Deusto-e-motion1.0 scores between groups of children depending on age and gender. Moreover, there was a moderately significant correlation between the emotional recognition scores of Deusto-e-motion1.0 and those of the Feel facial recognition test.

Conclusions

Deusto-e-motion1.0 shows concurrent validity with instruments that assess emotional recognition. Results support the adequacy of Deusto-e-motion1.0 in assessing components of the theory of mind in children.
Using Mobile Health Tools to Assess Physical Activity Guideline Adherence and Smoking Urges: Secondary Analysis of mActive-Smoke (Preprint)
Authors: Shan Rongzi , Yanek Lisa R , Silverman-Lloyd Luke G , Kianoush Sina , Blaha Michael J , German Charles A , Graham Garth N , Martin Seth S
Published: June 2019

BACKGROUND

Rates of cigarette smoking are decreasing because of public health initiatives, pharmacological aids, and clinician focus on smoking cessation. However, a sedentary lifestyle increases cardiovascular risk, and therefore, inactive smokers have a particularly enhanced risk of cardiovascular disease.

OBJECTIVE

In this secondary analysis of mActive-Smoke, a 12-week observational study, we investigated adherence to guideline-recommended moderate-to-vigorous physical activity (MVPA) in smokers and its association with the urge to smoke.

METHODS

We enrolled 60 active smokers (≥3 cigarettes per day) and recorded continuous step counts with the Fitbit Charge HR. MVPA was defined as a cadence of greater than or equal to 100 steps per minute. Participants were prompted to report instantaneous smoking urges via text message 3 times a day on a Likert scale from 1 to 9. We used a mixed effects linear model for repeated measures, controlling for demographics and baseline activity level, to investigate the association between MVPA and urge.

RESULTS

A total of 53 participants (mean age 40 [SD 12] years, 57% [30/53] women, 49% [26/53] nonwhite, and 38% [20/53] obese) recorded 6 to 12 weeks of data. Data from 3633 person-days were analyzed, with a mean of 69 days per participant. Among all participants, median daily MVPA was 6 min (IQR 2-13), which differed by sex (12 min [IQR 3-20] for men vs 3.5 min [IQR 1-9] for women; P=.004) and BMI (2.5 min [IQR 1-8.3] for obese vs 10 min [IQR 3-15] for nonobese; P=.04). The median total MVPA minutes per week was 80 (IQR 31-162). Only 10% (5/51; 95% CI 4% to 22%) of participants met national guidelines of 150 min per week of MVPA on at least 50% of weeks. Adjusted models showed no association between the number of MVPA minutes per day and mean daily smoking urge (P=.72).

CONCLUSIONS

The prevalence of MVPA was low in adult smokers who rarely met national guidelines for MVPA. Given the poor physical activity attainment in smokers, more work is required to enhance physical activity in this population.
La investigación científica como motor para el éxito de la publicidad
Authors: Pérez Pérez Rita María
Published: June 2019

Este trabajo tiene como objetivo principal determinar en qué medida el aporte científico ha abierto la posibilidad de aplicar estrategias publicitarias novedosas y positivas para el crecimiento del mercado. Analiza que el desarrollo de la publicidad se produce de forma paralela a la masificación del consumo, a la competencia del mercado y al crecimiento de la riqueza en los diferentes países, pues —en la medida en que disminuyen las carencias de los consumidores— la publicidad tiene que crear necesidades nuevas. Para ello precisa de la investigación científica que, ante las demandas actuales, desemboca en el neuromarketing. Como metodología hemos utilizado la observación participante, el análisis, la síntesis y los métodos inductivos y deductivos. La recopilación de información procedente de diversas fuentes bibliográficas relacionadas con el tema objeto de estudio, nos ha permitido recabar datos para construir un corpus teórico y metodológico para articular, comprender e interpretar la información con un mayor nivel de exactitud. El estudio revela que la investigación científica aplicada a la publicidad no solo ayuda al descubrimiento de herramientas publicitarias novedosas y positivas para ampliar la demanda, sino que advierte y previene sobre su comportamiento futuro para la búsqueda de nuevas soluciones.
Discusión de la aplicabilidad del desarrollo sostenible desde las políticas públicas en la República Dominicana y en Colombia según la adaptación educativa de la Agenda 2030
Authors: Murillo Garnica Jacqueline
Published: June 2019

El desarrollo sostenible con énfasis educativo se ha convertido en un elemento transversal en la agenda global, logrando vincular organizaciones sociales y estatales que se preocupan por el estado actual de los procesos de aprendizaje y de calidad de cada país, buscando continuamente que la adopción, mejoramiento y equilibrio entre la sociedad, los fundamentos económicos, el medio ambiente y la educación ocurran en el menor tiempo posible, en aras de mejorar las condiciones de vida y las relaciones humanas con el entorno. Este trabajo de investigación describe la aplicabilidad del “Desarrollo Sostenible” desde la perspectiva de las políticas públicas en materia de educación para los casos de Colombia y República Dominicana, con relación a los siguientes ejes: acceso, la calidad, la voluntad política y legalidad que tienen ambos países, entendiendo y abordando los enfoques que se le han dado en cada uno de los casos y que permiten que se gestionen reformas políticas, el desarrollo de proyectos internacionales y agendas de concertación multilaterales. Concibiendo las posturas temáticas autónomas de los casos de estudio. El estudio toma datos de fuentes oficiales con tal de mostrar los avances y los retrocesos concernientes a los ejes anteriormente planteados, entendiendo sus particularidades políticas, económicas y sociales, con fuerte incidencia en el desarrollo y adaptación del desarrollo sostenible.
La defensa del humanismo en el libro Narratividad del saber humanístico de Manuel Matos Moquete
Authors: Minaya Santos Julio
Published: June 2019

En la actualidad, el relato humanístico clásico ha sido desafiado por nuevos formatos teóricos y construcciones utópicas, surgidos en el seno de las ciencias biológicas, la cibernética y la inteligencia artificial. Estos saberes propugnan por el diseño de un nuevo ser humano, proyecto a favor del cual accionan posthumanistas y transhumanistas. En tal sentido, los valores en que se fundamentaban tanto el humanismo como las humanidades han sido cuestionados. Tal situación ha generado la emergencia de importantes discursos en el seno de diversas disciplinas. Uno de ellos es el que ha construido Manuel Matos Moquete en su libro Narratividad del saber humanístico. El presente trabajo constituye un esfuerzo por adentrarse en los planteamientos centrales del autor, cuya obra intenta dotar de sentido temas cruciales de nuestra época.
Editorial
Authors: Ulloa Hung Jorge
Published: June 2019

No precisa de un resumen
Octavio Paz como crítico de arte: la visión lúdica y contemplativa del mundo
Authors: Belliard Basilio
Published: June 2019

No precisa de un resumen
‘Operator, please’ — Connecting truth and power at the science-policy interface
Authors: Faehnrich Birte , Ruser Alexander
Published: June 2019

Today, science and politics are in a complex status of reciprocal dependency. Politics is dependent on scientific expertise in order to adequately address highly complex social problems, and science is fundamentally dependent on public funding and on political regulation. Taken together, the diverse interactions, interrelations and interdependencies of science and politics create a heterogenous and complex patchwork — namely, the science-policy interface. The societal relevance for phenomena such as scientific policy advice, science governance or (politically fostered) science communication have been amplified by the developments of digitalisation and now call for new approaches to clarify the ambiguous relationships within the science-policy interface. This special issue aims to provide a platform for researchers to address communication at the intersection of science and politics from different angles. The research presented in the special issue, thus, aims to reduce the contingency of science-policy communication in its various dimensions and looks to spur further investigations into the science-policy interface.
La responsabilidad social y la huella de carbono en las organizaciones
Authors: Cáceres Quevedo Armando
Published: June 2019

La primera parte se encarga de describir el comportamiento de la huella de carbono en las organizaciones, esta problemática es causada por el cambio climático y producido por la actividad humana y uno de los mayores desafíos ambientales que se pudiera interponer en el camino hacia el desarrollo sustentable. La huella de carbono es considerada una herramienta para cuantificar la emisión de gases efecto invernadero, el cálculo de la huella de carbono permite determinar el índice de co2, para reducir el nivel de emisiones de gas efecto invernadero. La implementación del programa Zero, encargado de identificar cuáles son las fuentes de emisiones de disposición de residuos industriales. El propósito fundamental es de cuidar el medio ambiente, sean convertidas en “ciudad verde” encargadas de medir el inventario de emisiones de gases efecto invernadero como resultado de la propuesta del “pacto climático Global de ciudades”. La segunda parte describe el modelo para implementar el cambio climático, enfocado en un plan de responsabilidad social empresarial hacia el medio ambiente delegado en proteger el medio ambiente, las acciones emprendidas hacia empresas productoras de vehículos que excedan la emisión de co2 y serán sancionadas en la Unión Europea a los vehículos que excedan la emisión de gases mínimos permitidos por las diferentes autoridades ambientales.