bluuebunny/crossref_metadata_2025 huggingface dataset:
Escuelas sin banderas: cultural material, identidades y educación (Campaña de Buenos Aires, 1820 a 1880)
Authors: Bustamante Vismara José
Published: September 2023

El artículo analiza aspectos de la cultura material de escuelas radicadas en la campaña de Buenos Aires en el período que va de 1820 a 1880, aproximadamente. Además de referencias a los edificios y sus aulas, se comparten los resultados del estudio de inventarios de escuelas. ¿Qué enseres aparecen en ellos? ¿Hay allí rasgos ligados a lo identitario? ¿Pueden reconocerse cambios en torno al asunto? Este texto se explora el asunto y plantea una cronología a modo de hipótesis.
Mujeres procesadas. Escuchas perceptivas en el juzgado correccional de La Plata (1896-1897)
Authors: Castells Florencia Claudia
Published: September 2023

A través del estudio de tres procesos judiciales, el artículo analiza las relaciones entre las narraciones de las mujeres procesadas por delitos violentos hacia sus parejas y las argumentaciones de los funcionarios del juzgado correccional de La Plata a fines de siglo XIX. En los relatos judiciales se examinan sentidos legales, sociales y de género en torno a la violencia marital. La perspectiva sensorial permite indicar que los agentes judiciales correccionales platenses escuchaban las experiencias de las agresoras y percibían sus sufrimientos, los cuales eran traducidos bajo criterios legales.
Entrevista a Abel Aníbal Zabala: el archivo de los payadores del Plata
Authors: Gómez Yáñez Mario Ernesto
Published: September 2023

En esta entrevista, el investigador Abel Aníbal Zabala comparte sus conocimientos sobre la payada y los payadores del Plata, adquiridos durante toda una vida y que ha materializado en conferencias y libros. En un amable gesto, Zabala procura proporcionar todos los datos, eventos y antecedentes con exactitud temporal. Entre los temas que se tocan, encontramos explicaciones sobre la constante relación transfronteriza entre payadores, opiniones sobre el trabajo de estos y, especialmente, la historia y características de su vasto archivo multimedial. Además, Zabala da a conocer qué investigadores lo han visitado y quiénes son los legatarios de las colecciones.
Sistem Penunjang Keputusan Pemilihan Pekerjaan Menggunakan Metode Profile Matching
Authors: Arfandy Hamdan , Erik Wijaya  , Musdar Izmy Alwiah
Published: September 2023

Tujuan dari penelitian ini adalah merancang aplikasi sistem penunjang keputusan pemilihan pekerjaan. Pekerjaan merupakan tujuan utama mahasiswa setelah lulus kuliah. Masalah yang muncul yakni banyak alumni yang tidak mengetahui dan masih bingung bidang pekerjaan apa yang akan ditekuninya. Pada penelitian ini dikembangkan sebuah sistem penunjang keputusan berbasis web dengan harapan dapat diakses via desktop dan mobile. Metode Profile matching digunakan untuk menghasilkan rekomendasi pekerjaan kepada pengguna sistem. Pengembangan aplikasi menggunakan framework bootstrap agar tampilan web lebih teratur. Pengujian sistem menggunakan metode black box dengan dua puluh lima test case. Hasil dari penelitian ini adalah sebuah sistem penunjang keputusan untuk rekomendasi pekerjaan telah berhasil dikembangkan dan telah melawati proses pengujian sistem. Hasil pengujian menunjukkan bahwa fungsi – fungsi sistem dapat berjalan sesuai dengan spesifikasi sistem serta  tidak ditemukan adanya kesalahan perhitungan kriteria dan hasil perankingan keputusan yang ditampilkan di sistem.
Penerapan Algoritma A* untuk Pencarian Rute Terpendek pada Aplikasi Game Shoot'em Up
Authors: Hasniati  , Rahman Syaiful , Suyono
Published: September 2023

Tujuan dari penelitian ini adalah mengimplementasikan algoritma A* untuk mencari jalan terpendek pada game shooter. Dalam perancangan sistem, use case diagram digunakan untuk menjelaskan kebutuhan fungsional sistem, dan activity diagram untuk menggambarkan alur kerja sistem. Sedangkan dalam pembuatan aplikasi yang dapat digunakan pada desktop bersistem operasi Windows digunakan Unity. Metode pengujian, yang digunakan dalam penelitian ini adalah metode black box untuk memvalidasi game dapat bekerja sesuai dengan rancangan sistem, kemudian pengujian beta dan software quality untuk memverifikasi bahwa algoritma A* telah diimplementasikan dengan baik. Hasil dari penelitian ini adalah 1) hasil pengujian menggunakan metode black box yang telah dilakukan dapat disimpulkan bahwa semua tombol dan fitur-fitur yang telah dirancang pada aplikasi dapat berfungsi dengan baik dan benar; 2) hasil pengujian endurance yang dilakukan, dapat disimpulkan bahwa A* sangat akurat dan selalu menemukan rute terpendek dalam waktu yang cepat, dan juga waktu pencarian rute terpendek sangat bergantung pada jumlah simpul.
Analisis Sentimen Komentar Pengguna Aplikasi Threads Pada Google Playstore Menggunakan Algoritma Multinominal Naive Bayes Classfier
Authors: Akbar Muhammad Nur , Nirwana Samrin
Published: September 2023

Kemajuan teknologi khususnya teknologi internet dan media sosial telah memungkinkan masyarakat di seluruh negeri untuk terhubung dan berinteraksi satu sama lain. Dalam konteks ini, Instagram menjadi platform yang populer bagi para content creator untuk berbagi karya mereka. Dalam upaya untuk bersaing dengan platform lain, Instagram meluncurkan aplikasi yang terintegrasi bernama Threads, yang memiliki beberapa fitur mirip dengan Twitter. Threads memungkinkan pengguna untuk berbagi unggahan berbasis teks dan menyediakan berbagai fitur lainnya. Untuk meningkatkan kualitas aplikasi ini, pengembang perlu memeriksa komentar pengguna. Namun, jumlah komentar yang masuk sangat banyak sehingga pemeriksaan manual tidak efisien. Oleh karena itu, diperlukan aplikasi otomatis yang dapat mengkategorikan komentar dan menganalisis sentimen pengguna. Dengan menggunakan teknik text mining untuk analisis sentimen, pengembang dapat dengan mudah memilah komentar menjadi positif dan negatif. Multinomial Naive Bayes dipilih karena dirancang khusus untuk data frekuensi kemunculan, seperti dalam analisis teks. Diharapkan bahwa aplikasi ini dapat membantu pengembang dalam meningkatkan kualitas aplikasi yang dihasilkan. Dari hasil penelitian ini didapatkan akurasi sebesar 76%, sudah cukup baik dan sangat memungkinkan untuk dikembangkan sehingga diperoleh hasil yang lebih baik.
The Influence of Sleman City Hall on Housing Price: A Case Study using OLX Data
Authors: Muna Muhammad Naurul , Hartarto Romi Bhakti , Hajar Ibnu
Published: September 2023

The Special Region of Yogyakarta (DIY) is one of the provinces in Indonesia with rapid development. This is indicated by the increasing number of shopping centers and the development of tourism and educational activities. Sleman Regency is a business center in DIY Province because it has the largest number of shopping centers in DIY Province compared to other districts. This study aims to determine whether the house adjacent to Sleman City Hall, the largest shopping center in Sleman Regency, has a higher selling price. While similar studies use primary data collected in the field through questionnaires, this study contributes to the property economics literature by utilizing secondary data from the OLX dataset to estimate the selling price of the house. A total of 229 data obtained through the OLX website related to selling prices, proximity to Sleman City Hall, and property characteristics were processed using multiple regression analysis with the ordinary least squares (OLS) technique. The finding of this study is that the distance from Sleman City Hall has a negative and significant effect on the selling price of the house. Another finding from this study is that the building area and land area have a positive and significant effect on the selling price of the house. On the other hand, the distance to the asphalt road has nothing to do with the selling price of the house.
Digital Technologies Application and Competitive Advantage for MSMEs Sustainability and Market Performance
Authors: Budiarto Dekeng Setyo , Amanda Ayuk , Nordin Norraini
Published: September 2023

The development of digital technology and intense competition have forced owners of small firms (MSMEs) to adapt technological developments to compete with competitors quickly. This study examines the effect of digitalization and competitive advantage on market sustainability and performance. This study used a qualitative method by distributing questionnaires to 166 MSMEs owners in Indonesia. The finding of this research indicate that digitalization and competitive advantage affect sustainability and market performance. This study's results suggest to MSMEs owners that technological proficiency is crucial for companies to survive in an uncertain environment.
Money Demand Analysis through Business Cycle in Indonesia
Authors: Melati Isna , Kurniawan Mahrus Lutfi Adi
Published: September 2023

There is still debate about the role of monetary aggregates (money demand) and their nature in the domestic economy, whether there is a direct affect and indirect affect. After the 2008 crisis, monetary aggregates became a monetary policy tool that played an important role in maintaining domestic economic stability. This study aims to examine macroeconomic variables on the demand for money in Indonesia from 2000Q1-2021Q4 using the VECM approach. The business cycle is used as a proxy for the income variable with the Hodrick-Prescott Filter method on the GDP variable. The results show that income has a high degree of variability in the demand for money and there is a sensitivity in the response of the demand for money to fluctuations in domestic interest rates. The implication of this research the application of domestic interest rates at the lowest level can encourage income which can increase the demand for money in Indonesia.
Study on the optimization of the quality management path of university physical education teaching in the context of multimedia network technology
Authors: Kuang Huali , Zhang Youan , Yin Meng , Chen Qiongxia
Published: September 2023

Physical education is the mainstream of physical education in general higher education institutions and is an important part of cultivating talents with comprehensive development. In this paper, to optimize the problem of video acquisition in physical education under multimedia, we adopt the tracking algorithm based on color information - CamShift algorithm to track the teacher’s target so that the teacher’s target is within the field of view of the camera to accomplish a better recording effect. Furthermore, for the problem that the CamShift algorithm is interfered with by class skin color, occlusion, and other problems that cause the algorithm to track incorrectly and the algorithm tracking is not robust, the optical flow tracking algorithm and Kalman filter method are combined to optimize the CamShift algorithm. Finally, a comparison is made between teaching with multimedia technology and previous teaching formats. The results show that three people in the test panel scored above 90 in the final assessment testing, while only one person in the comparison panel, 15 students (65.21%), scored between 85 and 90 in the experimental group, while 9 students (39.13%) scored between 85 and 90 in the control group. The grade point average of students’ theoretical knowledge in the experimental panel was 85.94, which exceeded the grade point average of 81.62 in the control group by 4.32 points; therefore, the optimized media recording effect based on the improved CamShift algorithm improved the teaching experience and the teaching quality of physical education by using multimedia teaching tools, and the research indexes achieved the expected results.
Innovative talent cultivation strategies for teaching traditional culture and language and literature based on information fusion technology
Authors: Li Qin
Published: September 2023

Language and culture are inextricably intertwined, and language and literature teaching cannot be separated from traditional Chinese culture. To study traditional culture and innovative talent cultivation strategies for language and literature teaching, this paper analyzes the current situation of language and literature teaching based on information fusion technology. Regarding curriculum structure, 21.5% of the students think that general education courses involving traditional culture should be increased. 81.2% of the students think there should be more practical studies or internships about traditional culture. In terms of course content, only 10.7% of students think that teachers have a strong connection between traditional culture and language and literature, 51.1% of students think the degree of connection is average, and 3.4% of students think that the teaching of language and literature has no connection with traditional culture at all.

Regarding course evaluations, 28.1% of the tests in language and literature focused on general competence, 42.3% on knowledge mastery, and 29.4% on research skills. The impact of teacher evaluations on students was considered average by 55.1%, great by 23.8%, and minimal by 21.1%. Language and literature teaching should effectively enhance curriculum specialization, improve students’ cultural awareness, and deeply explore the connotation of teaching materials. Innovative talent cultivation strategies based on information integration technology can promote the organic integration of language and literature teaching and Chinese traditional culture, ensure that students can truly take the inheritance and promotion of Chinese traditional culture as their responsibility, shoulder the historical mission of Chinese children, and help the great rejuvenation of the Chinese nation.
The impact of CS structured computer-assisted translation system on English linguistics teaching in universities
Authors: Li Yanxia
Published: September 2023

In the age of information technology, the teacher is no longer the only source of information, and a single lecture mode can trigger a range of messages for learning emotions. For this reason, this paper designs a cs-structured computer-aided translation system composed of machine translation in a neural network. After solving the exposure bias problem, the model regularization method combined with the bi-directional decoding consistency is used to optimize the assisted translation system. Then, aspects of the effectiveness of students’ use of the system on their English proficiency improvement were studied. The test scores of the test and comparison classes showed that the mean values of the scores before and after the test of the test class were 13.58 and 15.94, with a mean difference of 2.36 points. The mean values of the scores before and after the test of the comparison class were 14.58 and 14.94, respectively, with a mean difference of 0.4. Comparing the absolute values of the mean differences between the scores before and after the test of the two classes, it is clear that the test class improved their English proficiency level significantly more than the comparison class.

Furthermore, the overall satisfaction of the teachers using the system reached 85.62%. Therefore, in terms of traditional teaching methods, the assisted translation system is more capable of improving students’ English proficiency. It enables teachers to improve English teaching efficiency in the classroom and promotes the modernization and intelligence of English teaching.
Exploration and practice of combining theoretical teaching and practical teaching to implement course Civics in the context of big data--Take “Microbial Pharmaceutical Technology” as an example
Authors: Li Lingling
Published: September 2023

To better cultivate talents in the direction of “Microbiological Pharmaceutical Technology”. In this paper, we first mine the Civic Elements from the Microbial Pharmaceuticals course with the help of a clustering algorithm and calculate the similarity between data objects by Euclidean distance. Secondly, the Apriori algorithm is applied to find the largest set of frequent items in the data set of Civic Science elements and analyze them. Then the ID3 decision tree is used to calculate the information gain involving conditional entropy and information entropy, and then the data are classified. Based on the above algorithm, a Civics teaching platform combined with theoretical and practical teaching is constructed. Finally, to verify that the platform constructed in this paper achieves the combination of theoretical teaching and practical teaching, a set of simulation experiments is designed in this paper, taking “Microbial Pharmaceutical Technology” as an example, and the results show that applying the Civics Teaching Platform to the microbial pharmaceutical course, the number of teachers Civics teaching elements mining increases from 14 to 22, and the ability of Civics elements mining increases significantly. Thus, it can be seen that the implementation of the Civic Government teaching platform based on the big data algorithm of the course has improved the teaching ability of teachers and is conducive to the realization of the talent cultivation goal of the course “Microbial Pharmaceutical Technology”.
Breast cancer risk assessment and risk distribution in 3,491 Slovenian women invited for screening at the age of 50; a population-based cross-sectional study
Authors: Jarm Katja , Zadnik Vesna , Birk Mojca , Vrhovec Milos , Hertl Kristijana , Klanecek Zan , Studen Andrej , Sval Cveto , Krajc Mateja
Published: September 2023

Background

The evidence shows that risk-based strategy could be implemented to avoid unnecessary harm in mammography screening for breast cancer (BC) using age-only criterium. Our study aimed at identifying the uptake of Slovenian women to the BC risk assessment invitation and assessing the number of screening mammographies in case of risk-based screening.

Patients and methods

A cross-sectional population-based study enrolled 11,898 women at the age of 50, invited to BC screening. The data on BC risk factors, including breast density from the first 3,491 study responders was collected and BC risk was assessed using the Tyrer-Cuzick algorithm (version 8) to classify women into risk groups (low, population, moderately increased, and high risk group). The number of screening mammographies according to risk stratification was simulated.

Results

57% (6,785) of women returned BC risk questionnaires. When stratifying 3,491 women into risk groups, 34.0% were assessed with low, 62.2% with population, 3.4% with moderately increased, and 0.4% with high 10-year BC risk. In the case of potential personalised screening, the number of screening mammographies would drop by 38.6% compared to the current screening policy.

Conclusions

The study uptake showed the feasibility of risk assessment when inviting women to regular BC screening. 3.8% of Slovenian women were recognised with higher than population 10-year BC risk. According to Slovenian BC guidelines they may be screened more often. Overall, personalised screening would decrease the number of screening mammographies in Slovenia. This information is to be considered when planning the pilot and assessing the feasibility of implementing population risk-based screening.
The effects of normobaric and hyperbaric oxygenation on MRI signal intensities in T1
-weighted, T2
-weighted and FLAIR images in human brain
Authors: Velej Vida , Cankar Ksenija , Vidmar Jernej
Published: September 2023

Background

Dissolved oxygen has known paramagnetic effects in magnetic resonance imaging (MRI). The aim of this study was to compare the effects of normobaric oxygenation (NBO) and hyperbaric oxygenation (HBO) on human brain MRI signal intensities.

Patients and methods

Baseline brain MRI was performed in 17 healthy subjects (mean age 27.8 ± 3.2). MRI was repeated after exposure to the NBO and HBO at different time points (0 min, 25 min, 50 min). Signal intensities in T
1-weighted, T
2-weighted images and fluid attenuated inversion recovery (FLAIR) signal intensities of several intracranial structures were compared between NBO and HBO.

Results

Increased T
1-weighted signal intensities were observed in white and deep grey brain matter, cerebrospinal fluid (CSF), venous blood and vitreous body after exposure to NBO as well as to HBO compared to baseline (Dunnett's test, p < 0.05) without significant differences between both protocols. There was also no significant difference in T
2-weighted signal intensities between NBO and HBO. FLAIR signal intensities were increased only in the vitreous body after NBO and HBO and FLAIR signal of caudate nucleus was decreased after NBO (Dunnett's test, p < 0.05). The statistically significant differences in FLAIR signal intensities were found between NBO and HBO (paired t-test, p < 0.05) in most observed brain structures (paired t-test, p < 0.05).

Conclusions

Our results show that NBO and HBO alters signal intensities T
1-weighted and FLAIR images of human brain. The differences between NBO and HBO are most pronounced in FLAIR imaging.
A review of tumor treating fields (TTFields): advancements in clinical applications and mechanistic insights
Authors: Li Xing , Liu Kaida , Xing Lidong , Rubinsky Boris
Published: September 2023

Background

Tumor Treating Fields (TTFields) is a non-invasive modality for cancer treatment that utilizes a specific sinusoidal electric field ranging from 100 kHz to 300 kHz, with an intensity of 1 V/cm to 3 V/cm. Its purpose is to inhibit cancer cell proliferation and induce cell death. Despite promising outcomes from clinical trials, TTFields have received FDA approval for the treatment of glioblastoma multiforme (GBM) and malignant pleural mesothelioma (MPM). Nevertheless, global acceptance of TTFields remains limited. To enhance its clinical application in other types of cancer and gain a better understanding of its mechanisms of action, this review aims to summarize the current research status by examining existing literature on TTFields’ clinical trials and mechanism studies.

Conclusions

Through this comprehensive review, we seek to stimulate novel ideas and provide physicians, patients, and researchers with a better comprehension of the development of TTFields and its potential applications in cancer treatment.
Studi Terhadap Dampak Perjanjian Integrasi Vertikal Pada Industri Farmasi Ditinjau Dari Perspektif Hukum Persaingan Usaha
Authors: Windha Windha , Andriati Syarifah Lisa
Published: September 2023

Industri farmasi Indonesia menunjukkan konsentrasi pasar yang cukup tinggi dan cenderung oligopoli sehingga rentan terhadap praktik perjanjian integrasi vertikal yang dapat menyebabkan persaingan usaha tidak sehat. Perjanjian integrasi vertikal pada industri farmasi mampu menciptakan efisiensi, namun dapat menjadi sarana untuk menghambat persaingan usaha. Masalah yang diangkat dalam penulisan ini adalah bagaimanakah dampak perjanjian integrasi vertikal dan bagaimanakah prinsip pengujian dalam membuktikan perjanjian integrasi vertikal yang berdampak anti persaingan dalam industri farmasi. Metode penelitian yang diigunakan adalah metode penelitian yuridis-normatif dengan menggunakan data sekunder berupa peraturan perundang-undangan dan hasil penelitian awal KPPU yang digunakan untuk menganalisis permasalahan yang diangkat. Analisis data menggunakan analisis kualitatif dengan cara mengolah data menjadi suatu tanggapan untuk menjawab permasalahan. Hasil penelitian jurnal ini adalah integrasi vertikal pada industri farmasi dapat menciptakan efisiensi dan memperkuat stabilitas pasokan. Namun perusahaan yang terintegrasi akan mempunyai kemampuan untuk menciptakan market foreclosure. Pendekatan yang digunakan dalam membuktikan pelanggaran perjanjian integrasi vertikal adalah pendekatan rule of reason dengan prinsip pengujian analisis kemampuan, insentif, dan dampak konsumen. Saran yang dapat diberikan adalah diharapkan pemerintah atau pelaku usaha pesaing melakukan telaah terhadap perusahaan farmasi yang terintegrasi vertikal dan patut diduga telah menciptakan market foreclosure dengan menggunakan analisis kemampuan, insentif, dan dampak konsumen. Selanjutnya, hasil telaah harus ditindaklanjuti jika terdapat indikasi pelanggaran perjanjian integrasi vertikal yang dilakukan oleh perusahaan farmasi.
Uji Efektifitas Ekstrak Etanol Daun Arbei (Rubus rosifolius Sm.) Terhadap Penurunan Kadar Glukosa Darah pada Mencit Diabetes
Authors: Afriyeni Helmice , Rizal Rosiana , Armenia Armenia , Esfika Mike , Dillasamola Dwisari
Published: September 2023

Daun arbei (Rubus rosifolius Sm.) mengandung senyawa metabolit aktif seperti pomolic acid, tormentic acid, quercetin dan euscaphic acid yang berpotensi sebagai antihiperglikemia. Penelitian ini dilakukan untuk mengetahui pengaruh ekstrak etanol daun arbei (Rubus rosifolius Sm.) dan lama pemberian terhadap penurunan kadar glukosa darah mencit diabetes. Sebanyak 25 ekor mencit diinduksi dengan aloksan dosis 150 mg/kg secara intraperitonial. Pemeriksaan glukosa darah dilakukan dengan metode enzimatis menggunakan glukometer. Mencit dengan kadar glukosa darah sewaktu >200 mg/dL dibagi menjadi 5 kelompok yaitu kontrol positif (Na.CMC 0,5%), pembanding (glimepirid) dan kelompok ekstrak uji dosis 100, 200 dan 400 mg/kg. Perlakuan diberikan selama 15 hari dan pengukuran kadar glukosa darah dilakukan pada hari ke 5, 10 dan 15. Data hasil penelitian dianalisis menggunakan Anova Dua Arah dan dilanjutkan dengan uji Duncan post hoc pada tingkat kepercayaan 95%. Pemberian ekstrak uji berpengaruh signifikan (p<0.05) terhadap penurunan kadar glukosa darah mencit. Semua kelompok dosis ekstrak uji memberikan efek penurunan glukosa darah yang tidak berbeda signifikan (p>0.05) dengan kelompok yang diberi glimepiride. Efek penurunan kadar glukosa darah semakin besar seiring bertambah lama waktu pemberian ekstrak uji (p<0,05), nilai penurunan terbesar ditunjukkan pada hari ke 15. Hasil penelitian mengindikasikan ekstrak etanol daun arbei efektif menurunkan kadar glukosa darah dan nilai penurunannya sebanding dengan glimepirid.
Low carbon full life cycle energy
Authors: Gadirov Amal Allakhveran Ogli
Published: September 2023

At the current stage of energy development, it seems that in the coming years, it is hydrocarbon energy that will form the basis of the world energy market. However, there are a number of global changes that inevitably affect the energy industry, among them are: a change in the technological chains of the energy complex, the persistence of the problems of traditional energy, an increase in energy demand, the high impact of emissions from the use of hydrocarbons on the climate, and many others. In this regard, solutions related to low-carbon energy, in particular solar, wind, hydropower and other renewable energy applications, are becoming increasingly important. A special place in this segment is occupied by low-carbon full-cycle energy, which is studied in the article. In particular, in Russia, full-cycle low-carbon energy appears to be a very important part of the development of the energy industry, as it can significantly reduce costs and negative externalities for the environment. In this regard, one of the objectives of the study is to analyze the current situation in the field of low-carbon energy in the Russian Federation, its regulation, as well as development prospects, taking into account the special role of the Russian Federation as one of the key exporters of traditional hydrocarbons.
Motives and Images of Medieval Mysticism in the Works of Nikolai Gumilyov
Authors: Pisarenko Alena Yur'evna
Published: September 2023

This scientific article is devoted to the study of the influence of mystical motifs and images of the Middle Ages on the work of the Russian poet Nikolai Gumilev. The central task of the study is to analyze the specific works of the poet, in which the influence of mystical themes is most clearly traced. The article draws attention to various aspects of the interaction of mysticism and creativity, including structure, rhythm, language and images in Gumilev's works. The article uses methods of comparative analysis, textual interpretation and cultural and historical contextualization. Particular attention is paid to the reception of mystical elements in Gumilev's work among his contemporaries and critics, such as Marina Tsvetaeva and Anna Akhmatova. One of the conclusions of the study is that mystical motifs and images not only enrich Gumilev's creative world, but also serve as a key factor in the formation of his unique style. This, in turn, allows us to consider him one of the most significant and interesting authors of Russian literature of the early XX century. The novelty of the study is a detailed analysis of mystical elements in the context of Gumilev's general style and aesthetic principles, which was not previously considered in such completeness. These results may be useful for further study of the influence of mystical themes on Russian literature in general and on Gumilev's work in particular.
Adaptive Force-Control Augmentation for Small Celestial Body Sampling
Authors: Mohseni Nima , Bernstein Dennis S. , Quadrelli Marco B.
Published: September 2023

An adaptive force-control augmentation for small celestial body sampling for a variety of surface properties is developed. The control algorithm consists of a nominal robust controller augmented with an adaptive controller combined with feedback linearization. When a spacecraft makes contact with the surface, it must maintain a desired contact force in order to capture a sample. The properties of the surface are unknown or uncertain before contact with the surface is made. Because the nominal robust controller may have poor performance in some surface property regimes, the goal is to improve performance using an adaptive controller. The adaptive controller performs system identification online to create an input–output model of the feedback-linearized system. From the input–output model, a block-observable canonical form is realized and the control input augmentation is determined by model predictive control. The resulting augmentation is added to the input of the robust controller to improve the closed-loop performance and maintain a desired contact force despite the unknown surface properties. The approach is applied to a variety of surface properties with linear and nonlinear contact models and multiple surface sampling maneuvers.
The Construction of Identities
Authors: Aqeeli Ammar Abduh
Published: September 2023

This article explores how Naomi Wallace’s In the Heart of America demonstrates the interconnectedness of xenophobia, racism and other forms of discrimination in American life and politics. Through the critiques offered by Louis Althusser, Michel Foucault and Judith Butler, this article investigates the relationships between ideological state apparatuses, production of power and the construction of social identities. The subjugated characters in the play attempt to resist, negotiate and accommodate normative or regulative discursive processes that impose fixed identities upon them. Wallace’s play demonstrates that resistance constitutes power, which can be either weak, submissive, creative, and/or productive. Raising awareness of the possibilities of resistance to subjectifying power is what In the Heart of America yearns to do.
Experiencias sexo-afectivas en tiempos de crisis sanitaria por COVID-19 en Argentina, Ecuador y México
Authors: Sánchez-Medina Ricardo , Enríquez-Negrete David , Rosales-Piña Consuelo , Zambrano-Villalba Carmen , Losada Analía
Published: September 2023

Se llevó adelante un estudio empírico utilizando metodología cuantitativa, a través de un diseño transversal, con una muestra de 300 personas, a través de un muestreo por conveniencia conformada por 100 hombres y mujeres argentinos, y en la misma proporción 100 ecuatorianos y 100 mexicanos. Grosso modo se encontraron pocas diferencias entre las muestras, lo anterior podría deberse a que comparten características similares al ser latinoamericanos, ecuatorianos y mexicanos reportaron más el uso de apps de citas para tener encuentros sexuales durante este periodo. En cuanto a la tensión en la relación de pareja, los mexicanos reportaron mayor presión y experiencias sexuales negativas. En esta línea, cerca de un 30% reportaron haber tenido relaciones sexuales con personas que no vivían con ellos, pero reportaron que un tema de conversación fue el contacto con personas con infección por COVID-19, siendo los ecuatorianos quienes consideran una mejor idea, el uso de mascarilla durante los encuentros sexuales. Se concluye sobre la importancia de generar intervenciones orientadas al manejo de uso de apps para conseguir pareja, debido a que los participantes han incrementado su uso, y un mal manejo puede traer algunas consecuencias negativas. Si bien los participantes reportaron sentirse bien en sus relaciones de pareja, en el caso de los mexicanos se encontraron algunos riesgos asociados con la violencia, de tal forma que también se deben generar programas de prevención y tratamiento.
Auriculoterapia e ventosaterapia para alívio de ansiedade pós-COVID-19: estudo de caso
Authors: Leonel Gabriela Aparecida , Silva Vitoria Cristina , Oliveira Savana Raabe de , Silva Taline Gonçalves da , Chaves Rafael Lopes , Oliveira Marina das Dores Nogueira de , Andrade Maria Betânia Tinti de , Chaves Érika de Cássia Lopes , Chini Lucélia Terra
Published: September 2023

Objetivo: Avaliar a eficácia da auriculoterapia e ventosaterapia na redução da ansiedade em uma paciente com Síndrome Pós-Covid. Detalhamento do caso: Trata-se de um estudo de caso, em que foi avaliado e tratado uma paciente do sexo feminino, 50 anos, professora universitária, com queixa principal de ansiedade como sintoma da Síndrome Pós-Covid. Inicialmente aplicou-se um questionário estruturado pelos autores para avaliação clínica e o pentagrama para avaliação energética da paciente. O protocolo de tratamento foi baseado no uso das práticas da Medicina Tradicional Chinesa de acupuntura auricular e ventosaterapia, administrados em seis sessões, sendo uma vez por semana e com duração de 30 minutos cada. O estudo foi aprovado pelo Comitê de Ética em Pesquisa. Durante as sessões foram relatados sensação de relaxamento e prazer, e, após a aplicação das técnicas foram observados redução dos níveis de ansiedade, estresse e preocupação, além de melhora na qualidade do padrão de sono e de qualidade de vida em geral. Considerações finais: O tratamento com acupuntura auricular associado a ventosaterapia apresenta-se como uma opção eficaz para melhora dos quadros de ansiedade associada a pós infecção pela COVID-19.
Spirostrain-Accelerated Chemiexcitation of Dioxetanes Yields Unprecedented Detection Sensitivity in Chemiluminescence Bioassays
Authors: Tannous Rozan , Shelef Omri , Gutkin Sara , David Maya , Leirikh Thomas , Ge Liang , Jaber Qais , Zhou Qingyang , Ma Pengchen , Fridman Micha , Spitz Urs , Houk Kendall N. , Shabat Doron
Published: September 2023

Chemiluminescence is a fascinating phenomenon involving the generation of light through chemical reactions. The light emission from adamantyl-phenoxy-1,2-dioxetanes can glow from minutes to hours, depending on the specific substituent present on the dioxetane molecule. In order to improve the light emission properties produced by these chemiluminescent luminophores, it is necessary to induce the chemiexcitation rate to a flash mode wherein the bulk of light is emitted instantly rather than slowly over time. We report the realization of this goal through the incorporation of spirostrain release into decomposition of 1,2-dioxetane luminophores. DFT computational simulations provided support for the hypothesis that the spiro-cyclobutyl accelerates chemiexcitation as compared to the unstrained adamantyl substituent. Spiro-linking of cyclobutane and oxetane units led to greater than 100-fold and 1000-fold emission enhancement, respectively. This accelerated chemiexcitation rate increases the detection sensitivity for known chemiluminescent probes to the highest signal-to-noise ratio documented to date. A turn-ON probe, containing a spiro-cyclobutyl unit, for detecting the enzyme β-galactosidase, exhibited a Limit-of-Detection value that is 125-fold more sensitive than the previously described adamantyl analogue. This probe was also able to instantly detect and image β-gal activity with enhanced sensitivity in E. coli bacterial assays.
Peri-Anthracenethioindigo: a Scaffold for Efficient All-Red-Light and NIR Molecular Photoswitching
Authors: Köttner Laura , Ciekalski Elias , Dube Henry
Published: September 2023

Photoswitching with red light is a greatly desired capability to evade photodamage and achieve specific photoresponses. In virtually all cases however, only one switching direction uses red light while for the reverse switching UV or visible light is needed. All-red-light photoswitching brings with it the obvious advantage of pushing photoswitching to the limit of the low-energy spectrum but no viable system is available currently. In this work we report on peri-anthracenethioindigo (PAT) as molecular scaffold for highly efficient all-red-light photoswitching with outstanding performance and property profile. The PAT photoswitch provides NIR absorption up to 850 nm, large negative photochromism with more than 140 nm maxima shifts and changes color from green to blue upon irradiation with two shades of red light. Thermal stability of the metastable Z isomer is high with a corresponding half-life of several days at 20 °C. Application for red-light responsive polymers undergoing pronounced and reversible green to blue color changes is demonstrated evidencing spatially resolved photoswitching. The PAT photoswitch thus offers unique responsiveness to very low energy light together with predictable and large geometrical changes within a rigid molecular scaffold. We expect a plethora of applications for PAT in the near future in all chemistry-related areas.
Hematocrit-independent sampling enables white blood cell counts from patterned dried blood spot cards
Authors: Tierney Allison J. , Williamson Kim C. , Stewart V. Ann , Mace Charles R.
Published: September 2023

The accurate and efficient measurement of white blood cell (WBC) counts is vital for monitoring general patient health and can aid in diagnosing a range of possible infections or diseases. Even with their importance universally acknowledged, access to WBC counts is largely limited to those with access to phlebotomists and centralized clinical laboratories, which house the instrumentation that perform the tests. As a result, large populations of people (e.g., those that are home-bound or live in remote locations) lack facile access to testing. Dried blood spot (DBS) cards are often used to bridge these gaps in access to testing by offering the ability to collect blood at home for ambient shipping to laboratories. However, it is well understood that these cards, which are prepared from cellulose cardstocks without further modification, suffer from variabilities in accuracy and precision due to uncontrolled sample spreading and hematocrit effects, which has hindered their use to determine WBC counts. In this manuscript, we present a method to obtain an accurate WBC count using a patterned dried blood spot (pDBS) card, which comprises collection zones that meter volumes of dried blood. We demonstrate that, unlike the gold standard DBS card (Whatman 903), our pDBS design allows for the collection of a reproducible, average volume of blood volume over the range of hematocrits from 25–55%. We then used qPCR to quantify the 18S rRNA gene to determine WBC counts from the volumes of blood that are metered in pDBS zones. We observe that WBC counts generated from our method are comparable to those measured by a HemoCue point-of-care WBC analyzer. Our approach to using pDBS cards as a blood collection device has the potential to support at-home sampling and other patient populations that need WBC counts but lack access to clinical facilities.
Adsorptive sequestration of methylene blue in single and multicomponent systems: kinetics, isotherm and thermodynamic
Authors: Dabo Olawale , Aderibigbe. O Deborah , Giwa Abdur-Rahim
Published: September 2023

The surge in world population in conjunction with the fast fashion industry has created substantial increase in textile production leading to an enormous release of wastewater containing dyes into water bodies. In this study, the adsorption of methylene blue (MB) in single, binary and in ternary dye system comprising of methylene blue (MB), acid blue 161 (AB 161) and crystal violet (CV) onto formaldehyde-treated watermelon rind (FWMR) was investigated as a function of pH, contact time, temperature, dosage and initial dye concentration. The watermelon rind was characterized using Scanning electron microscope, Fourier transform infrared spectroscopy and pH point of zero charge. Batch adsorption experiments were carried out to investigate the isotherm, thermodynamics and kinetics of the adsorption processes. The adsorption process was described by Freundlich isotherm in single system, Langmuir isotherm in binary and ternary system. The change in entropy (ΔS) and heat of adsorption (ΔH) of dye species on FWMR in were 1.076 kj/mol and 26.162 kj/mol respectively.
TGA-FTIR Guided Ligand Evaluation for Iron Photocatalyzed Decarboxylative Giese Reactions
Authors: Ackerman-Biegasiewicz Laura K.G. , Crocker Michael S. , Lin Jung-Ying , Nsouli Reem , McLaughlin Nathan D.
Published: September 2023

A general Fe photocatalyzed Giese reaction was developed using a unique analytical technique for synthetic organic chemistry: Thermal Gravimetric Analysis-Fourier Transform Infrared Spectroscopy (TGA-FTIR). The optimized Giese conditions proceed with low loadings of a simple Fe salt with a commercial amine ligand and obviates the need for the traditional large excess of one coupling partner to facilitate radical capture. This protocol enables the successful coupling of primary, secondary, and tertiary carboxylic acids with sterically hindered, cyclic, and acyclic electron-deficient acceptors. Additionally, methylation of acceptors proceeds smoothly at room temperature from commercial acetic acid. Protected amines, heterocycles, and electron-rich alkenes are well-tolerated, enabling functionalization of Osimertinib, a kinase inhibitor for non-small-cell lung carcinoma. Preliminary investigation of the reaction mechanism was consistent with formation of an Fe-carboxylate species followed by a light-promoted decarboxylation. TGA-FTIR was used to evaluate ligand trends for Fe carboxylates. Using 30-minute decomposition times a correlation was revealed between Fe carboxylate CO2 extrusion time and the yield attained with aliphatic amine ligands coordinated to Fe. Less substituted amine ligands gave greater yields of product and could eliminate the need for stoichiometric quantities of base and provide control for decarboxylation chemistry over hydrogen atom transfer chemistry.
Native Mass Spectrometry Dissects the Structural Dynamics of an Allosteric Heterodimer of SARS-CoV-2 Nonstructural Proteins
Authors: Thibert Stephanie , Reid Deseree , Wilson Jesse , Varikoti Rohith , Maltseva Natalia , Schultz Katherine , Kruel Agustin , Babnigg Gyorgy , Joachimiak Andrzej , Kumar Neeraj , Zhou Mowei
Published: September 2023

Structure-based drug design, which relies on precise understanding of the target protein and its interaction with the drug candidate, is dramatically expedited by advances in computational methods for candidate prediction. Yet, the accuracy needs to be improved with more structural data from high throughput experiments, which are challenging to generate, especially for dynamic and weak associations. Herein, we applied native mass spectrometry (native MS) to rapidly characterize ligand binding of an allosteric heterodimeric complex of SARS-CoV-2 two nonstructural proteins (nsp) nsp10 and nsp16 (nsp10/16). Native MS showed that the dimer is in equilibrium with monomeric states in solution. Consistent with literature, well characterized small co-substrate, RNA substrate and product bind with high specificity and affinity to the dimer but not the free monomers. Unsuccessfully designed ligands bind indiscriminately to all forms. Using neutral gas collision, the nsp16 monomer with bound co-substrate can be released from the holo dimer complex, confirming the binding to nsp16 as revealed by the crystal structure. However, an unusual migration of the endogenous zinc ions bound to nsp10 to nsp16 after collisional dissociation was observed, and can be suppressed using an alternative surface collision method at reduced precursor charge states. This highlighted the importance of careful optimization of experimental techniques. Overall, with minimal sample input (~µg), native MS can rapidly detect ligand binding affinities and locations in dynamic multi-subunit protein complexes, demonstrating the potential of an “all-in-one” native MS assay for rapid structural profiling of protein-to-AI-based compound systems to expedite drug discovery.
Barriers to Evidence-based Practice
Authors: Raja PT Dr. Kavitha
Published: September 2023

None
Analysis of the Combined Effects of Myofascial Release and Postero
Anterior Mobilization in Chronic Non-Specific Low Back Pain: A Randomized
Control Trial
Authors: Sharma Himanshu , M Srinivasulu , Y Manjulavani
Published: September 2023

Background amp Objective Lumbar stiffness is a very common
condition. About 60-80 of population suffer from this condition at any stage
of life. The aim of this study was to investigate the effects of
incorporating Myofascial Release MFR with Posterior Anterior PA mobilization
in addition to conventional therapy compared to conventional therapy alone
on the pain levels measured by the Visual Analog Scale VAS lumbar flexion
range of motion ROM measured by the modified Schobers test and functional
ability assessed by the Oswestry Low Back Pain Disability Index
questionnaire ODI in patients with low back pain.Method Sixty subjects were
included in the study. After obtaining informed consent from the patients
they were assigned to two groups with thirty subjects in each group Group A
n30 and Group B n30 as part of the experimental study design. For Group A
the control group conventional therapy was administered while in Group B the
experimental group MFR Myofascial Release with PA Posterior Anterior
mobilization were given along with conventional therapy. Pain was measured
using the Visual Analog Scale VAS lumbar flexion range of motion ROM was
measured using the modified Schobers test and functional ability was
assessed using the Oswestry Low Back Pain Disability Index questionnaire
ODI.Results Significant improvements were observed in both the groups in
terms of pain VAS and functional ability ODI p lt.000. Group B showed
greater improvement in pain reduction mean difference 2.200 vs. 1.567 and
functional ability mean difference 7.233 vs. 4.167 compared to Group A. Both
the groups demonstrated significant increase in lumbar flexion ROM p lt.000.
No significant differences were found between the groups for VAS ROM and ODI
p gt.05.Conclusion MFR with the PA mobilization reduces pain and improves
lumbar flexion ROM and functions in Chronic Non-Specific Low Back Pain
CNSLBP cases.
Profile of Work Related Musculoskeletal Disorders among Hospital Workers
- A Survey
Authors: Priyanka Shirsath , Muhammed Rashid , Saumen Gupta
Published: September 2023

Background and Aim Work related musculoskeletal disorders
WRMSDs usually develop from repetitive injuries resulting from months or
years of exposure to excessive levels of physical or psychological stressors
at work. Insufficient data on overall incidence of WRMSDs among hospital
workers from India has been noted with lack of organization in sector data.
This study aimed at identifying the burden of WRMSDs among hospital based
workers. This study was planned as a case study involving a single
hospital.Methods The present study was conducted at a multispecialty
hospital involving 1240 employees. They were interviewed using Standardized
Nordic musculoskeletal questionnaire NMQ.Results Overall 84.35 workers
reported pain in hip knee and ankle followed by 76.53 reporting pain in
upper and lower back 36.85 in neck and shoulder 10.80 in wrist and 5.4 in
elbow.Conclusion Hip knee and ankle followed by upper back and lower back
were found to be the most affected areas among hospital workers. Work
related musculoskeletal disorders are common among hospital employees with
majority of them reporting pain in multiple body areas. Adequate measures
should be considered to resolve work related musculosketal disorders.nbsp