bluuebunny/crossref_metadata_2025 huggingface dataset:
ANÁLISE DO COMBATE AO TRÁFICO DE PESSOAS PARA FINS DE EXPLORAÇÃO SEXUAL
Authors: Scopel Vieira Eduarda , Jacob Alexandre
Published: January 2025

Trata do tráfico de pessoas para fins de exploração sexual, no âmbito internacional e interno, a partir da vigência da Lei nº. 13.344/2016, que foi um marco significativo no Brasil, revogando os artigos anteriores que tratavam dos respectivos crimes, com uma abordagem mais ampla que inclui prevenção, repressão e assistência às vítimas. Destaca que o histórico desse crime remonta à Antiguidade, intensifica-se com o início do Renascimento, quando o Brasil começou a ser um país fornecedor de pessoas para exploração sexual. Analisando as rotas do tráfico, que se espalham por várias regiões do Brasil, e também para outros países como Espanha e Portugal como destinos frequentes das vítimas. Apresenta o perfil das vítimas e como os aliciadores agem para ludibriá-las. Conclui sobre a importância da conscientização sobre as condutas e os mecanismos de combate ao tráfico.
LOGÍSTICA ESTRATÉGICA E COMPETITIVIDADE NO MERCADO DE COSMÉTICOS: UMA ANÁLISE DE PEQUENAS E MÉDIAS EMPRESAS NO MUNICÍPIO DE LINHARES
Authors: Fernandes Oliveira Clarice , Santos Ribeiro Tátila , Pimenta Valadares Luciano
Published: January 2025

A indústria da beleza, marcada por constante expansão e alta competitividade, exige soluções inovadoras e eficientes para garantir o sucesso empresarial. Nesse cenário, as estratégias adotadas nos processos logísticos desempenham um papel essencial, integrando atividades como gestão de estoque, transporte e distribuição para atender às demandas do mercado de forma ágil e eficaz. Este estudo, realizado no município de Linhares, analisa a influência da logística estratégica em pequenas e médias empresas do setor de cosméticos, identificando seus principais desafios e o impacto na competitividade. Através de entrevistas e questionários com gestores locais, a pesquisa evidencia práticas que agregam valor e impulsionam o desempenho das organizações. Os resultados destacam a importância de uma gestão logística eficiente como elemento-chave para a otimização de processos, redução de custos e fortalecimento da posição de mercado das empresas de cosméticos em Linhares.
ABORDAGEM ODONTOLÓGICA DE PACIENTES HIPERTENSOS
Authors: Santana Beatriz Silva , Carvalho Fábio Silva de , Carvalho Cristiane Alves Paz de
Published: January 2025

Objetivo: Verificar a abordagem dos Cirurgiões-Dentistas em relação ao atendimento de pacientes hipertensos. Metodologia: Foi realizado um estudo descritivo, transversal e observacional, com abordagem quantitativa. A amostra foi composta por Cirurgiões-Dentistas que atuam na rede privada de serviços de saúde de um município baiano, identificados por meio do Cadastro Nacional de Estabelecimentos de Saúde. O instrumento de coleta de dados foi um questionário na forma de entrevista semiestruturada, que permitiu caracterizar os profissionais e verificar conhecimentos e condutas relacionadas ao paciente hipertenso. Resultados: Em relação ao critério atual para o diagnóstico da Hipertensão Arterial Sistêmica 38,9% afirmaram que é a pressão arterial sistólica 140-159 e a diastólica 90-99, sendo que a maioria limita o atendimento de urgência odontológica a pacientes com pressão arterial de até 140/90 mmHg. Quanto a conduta dos profissionais em relação aos pacientes hipertensos, 58,3% aferem a pressão arterial do paciente apenas em casos cirúrgicos, e 45,8% aferem de todos os pacientes. Aproximadamente 47,0% costumam utilizar soluções anestésicas com vasoconstrictor em pacientes compensados e sem vasoconstrictor para pacientes descompensados, e 44,4% utilizam até três tubetes de anestésico por sessão. Como métodos utilizados para evitar o aumento da pressão arterial durante o atendimento odontológico por motivos de medo/ansiedade, 38,9% dos profissionais mencionaram a conversa, condicionamento psicológico, fármacos benzodiazepínicos, relaxamento muscular e até mesmo sedação para controle do paciente. Conclusão: Foi possível identificar pouco conhecimento dos profissionais sobre a hipertensão arterial sistêmica, porém suas condutas estão relativamente adequadas.
Método Heurístico de Pólya como Estrategia Pedagógica para la Resolución de Problemas Matemáticos
Authors: Rodríguez Ayala José Luis , Celi Pasaca Karen Maritza , Oviedo Cumbícus Mercy Faviola , Gallegos Suquilanda Santiago Vicente , Alejandro Maza Robert Iván
Published: January 2025

La implementación del método heurístico de Pólya como estrategia pedagógica representa una herramienta eficaz para estructurar la resolución de problemas matemáticos. Esta investigación tiene como objetivo analizar cómo el método contribuye al desarrollo de habilidades en este ámbito, así como examinar la correcta aplicación de sus fases. El estudio se llevó a cabo mediante una investigación documental, basada en una revisión exhaustiva de libros, revistas científicas y artículos académicos de reconocida fiabilidad, con el propósito de proporcionar una fundamentación sólida a las variables estudiadas. Los resultados obtenidos revelan que la aplicación del método heurístico de Pólya genera un impacto positivo en los estudiantes. Este enfoque fomenta el desarrollo de habilidades organizativas y pensamiento crítico, al tiempo que promueve la adopción de múltiples perspectivas para abordar un problema. Además, se observó que los estudiantes ganan confianza en sí mismos al trabajar con un proceso sistemático y estructurado desde el inicio hasta la solución final. Estas características refuerzan la relevancia del método como una estrategia pedagógica clave en la enseñanza de matemáticas, consolidándolo como un medio efectivo para potenciar competencias esenciales en el ámbito educativo, especialmente aquellas relacionadas con la organización, el análisis lógico y la creatividad en la resolución de problemas.
El Laboratorio de Matemática para el proceso de enseñanza aprendizaje
Authors: Celi Pasaca Karen Maritza , Vivanco-Román Jorge , Oviedo Cumbícus Mercy Faviola , Vásquez Villalta Karina Jhanova , Gallegos Suquilanda Santiago Vicente
Published: January 2025

Un laboratorio es una propuesta de optimización del proceso de enseñanza aprendizaje, que se puede implementar en cualquier institución educativa; como tal, la finalidad de la investigación fue determinar la importancia del Laboratorio de Matemática para el proceso de enseñanza aprendizaje de las asignaturas de Matemática en la Carrera de Pedagogía de las Ciencias Experimentales: Matemáticas y la Física, de la Universidad Nacional de Loja. Fue un estudio de enfoque mixto, de tipo descriptivo y exploratorio, con una línea de diseño no experimental, aplicando las técnicas de revisión documental, fichaje y encuesta, con instrumentos como: bitácora de búsqueda, fichas bibliográficas y de contenido y cuestionario, respectivamente. Entre los principales resultados se encuentra que el laboratorio como ambiente de aprendizaje aporta significativamente a la enseñanza y aprendizaje de esta disciplina, por cuanto facilita la conexión entre la teoría matemática y su aplicación práctica en el entorno real. Por lo tanto, se concluye que es importante y necesario implementar un Laboratorio de Matemática en la Carrera de Pedagogía de las Ciencias Experimentales: Matemáticas y Física, como metodología para mejorar la calidad de la enseñanza aprendizaje de Matemática y contribuir al perfil profesional de los estudiantes.
The Distortion of Islamic Religion since Prehistoric Times: A Study of Quranic Archaeology
Authors: Akbar Ali
Published: January 2025

Religion has been analysed using various approaches of different disciplines. Based on the evolution approach, religion has evolved from animism during prehistoric times to polytheism and monotheism in modern times. One of the modern religions is Islam as a monotheist religion which relies on Al-Qur’an as the main religious source. This paper will analyse Islam based on Al-Qur’an specifically using a study of Quranic Archaeology. Al-Qur’an is considered as an archaeological data which is comprised of names, objects, and locations. This paper is also the result of a field work conducted at several locations mentioned in Al-Qur’an. The results are analysed using comparative method on the people’s situation from time to time. Based on this study, Islam did not evolve because it has been a monotheist religion since the beginning which then experiences distortion both in the form of animism and polytheism.
Pengaruh Struktur Modal, Likuiditas, dan Ukuran Perusahaan Terhadap Profitabilitas Pada Perusahaan Industrials Periode 2021-2023
Authors: Attoriq Suryana  , Irda Rosita  , Lisa Amelia Herman
Published: January 2025

This research aims to examine the influence of capital structure, liquidity, and company size on the profitability of the company. The data used in this study are secondary data obtained from the company's annual financial statements. This research focuses on companies operating in the industrial sector listed on the Indonesia Stock Exchange for the period 2021 to 2023. The number of samples in this study is 29 companies and 87 samples after excluding outliers. The sampling technique used the purposive sampling method. To test the research hypothesis, a multiple linear regression analysis was conducted using SPSS Statistic 26. The results of this study indicate that capital structure does not have a significant effect on the profitability of the company. Liquidity has a positive and significant effect on the profitability of the company, and the size of the company has a positive and significant effect on the profitability of the company. Simultaneously, capital structure, liquidity, and company size affect the profitability of industrial sector companies listed on the Indonesia Stock Exchange for the period 2021-2023.
ANALISIS PERENCANAAN PENGELOLAAN KEUANGAN DESA (Studi Kasus Pada Desa Nogosari Kecamatan Rambipuji Kabupaten Jember)
Authors: Mohamad Nabil Tanzil Furqon  , Sigiet Rizky Fidiyanto  , Alvin Safana Lufky  , Vivant Juniar Yasinof  , Rendy Chairul Ramadhany  , Bintang Wahyu Prayogo
Published: January 2025

Penelitian ini bertujuan untuk menjelaskan dan menganalisis proses perencanaan dan pengelolaan keuangan di Desa Nogosari, Kecamatan Rambipuji, Kabupaten Jember. Berdasarkan Permendagri Nomor 20 Tahun 2018. Penelitian ini menggunakan pendekatan kualitatif dan studi kasus yang melibatkan wawancara dengan perangkat desa serta analisis dokumen terkait. Hasil dari penelitian menunjukkan bahwa Proses perencanaan pengelolaan keuangan desa di Desa Nogosari sudah berjalan dengan baik, dan sudah mengikuti prosedur ataupun dasar hukum yang digunakan yaitu permendagri No. 20 Tahun 2018. Penelitian ini menekankan pentingnya perencanaan pengelolaan desa yang sesuai dengan Peraturan Menteri Dalam Negeri (Permendagri) Nomor 20 Tahun 2018
Penerapan Akuntansi Lingkungan Dalam Mendukung Keberlanjutan Perusahaan
Authors: Wulan Rama Wati  , Ersi Sisdianto
Published: January 2025

Abstrak. The implementation of environmental accounting is a strategic step in supporting corporate sustainability. Environmental accounting aims to identify, measure, and report financial and non-financial information related to the environmental impacts of a company's activities. This study explores the importance of adopting environmental accounting as part of a corporate sustainability strategy to address global challenges such as climate change and increasing public awareness of environmental issues. The research method includes literature analysis and case studies of companies that have implemented environmental accounting. The findings reveal that environmental accounting enhances resource efficiency, reduces negative environmental impacts, and fosters a positive corporate image among stakeholders. Therefore, environmental accounting serves not only as a tool to meet legal obligations but also as a strategic approach to holistically support corporate sustainability.
Keywords: Environmental accounting, corporate sustainability, environmental impact, resource efficiency, sustainability strategy.
Transformasi Digital dan Pertumbuhan E-Commerce: Dampak, Peluang, dan Tantangan di Era Modern
Authors: Edita Rachma Kamila  , Anala Ilfi Xena Andini  , Tutie Azzahra
Published: January 2025

Digital transformation has brought changes in the business world, especially in the e-commerce sector which is experiencing rapid growth. The existence of e-commerce supports operational efficiency, accelerates transactions, and expands market access. By 2022, this sector will contribute 64.5% to Indonesia's total digital economy. However, digital transformation also poses challenges. This study aims to explore the impact, opportunities and challenges commonly faced by businesses in facing this modern era of digitalization. This research uses a qualitative approach, secondary data obtained from various sources such as scientific journals, industry reports, and publications and then analyzed inductively with content analysis techniques. The results show that digitalization provides great opportunities for businesses to reach a wider market, optimize operational efficiency, and increase customer engagement. However, there are also challenges such as data security issues, intensified competition, and the need for large technology investments. This research is expected to provide insights for businesses and relevant stakeholders in adopting the right strategies to maximize digital opportunities while overcoming various challenges.
Peran Sumber Daya Manusia dan Strategi Meminimalkan Risiko untuk Meningkatkan Kinerja Perusahaan
Authors: Wahyu Yuda Pradana  , Arba Sunur  , Bima Andika  , M Farid Abrar  , Arsyadona Arsyadona
Published: January 2025

Companies engaged in the field of service providers or production of goods have the same goal, namely to make a profit, in addition to making a profit, every company certainly wants to provide products or services that can provide satisfaction to each of its customers by including risk management in it. Risk management can be interpreted as a method used by companies to find out, monitor, and control the risks that will arise from business activities. Risk management seeks to improve company performance. In risk management in minimizing company problems, it needs to be carried out by a company leader such as identifying, measuring, and handling a company risk. The purpose of this study is to provide a strategy to improve company performance by preparing good human resources and minimizing the risks that exist in a company.
Repressions against the families of participants of resistance in Western Ukraine (1944–1952)
Authors: Vronskaja Tamara
Published: January 2025

The repressive deportations of 1944–1952 took on a massive and brutal character in Western Ukraine, whose population was actively involved in the national liberation movement. They began in the first months of the Second World War and took place in the spring of 1944, when the liberation of Ukraine from Hitler’s occupiers was still a long way off. Already then, the party leaders in many official documents began to threaten women and children with repression, openly stating that they would use family hostage-taking alongside armed methods to achieve their desired goal of turning western Ukraine into a 100 per cent Soviet country.
KEPERCAYAAN DAN KEMUDAHAN DALAM PENGGUNAAN QUICK RESPONSE CODE INDONESIAN STANDARD (QRIS) DI PASAR TRADISIONAL (STUDI KASUS PELAKU UMKM DI PASAR WELERI)
Authors: Yanti Pujiastuti
Published: January 2025

Penelitian ini bertujuan untuk mengetahui pengaruh kepercayaan, kemudahan, manfaat, dan persepsi terhadap minat pelaku UMKM dalam menggunakan QRIS. Jenis data penelitian ini adalah penelitian kuantitatif. Populasi pada penelitian ini adalah pelaku UMKM di Kec. Weleri. Teknik pengambilan sampel pada penelitian ini adalah cluster sampling. Teknik pengumpulan data pada penelitian ini menggunakan kuesioner dengan skala likert dan sampel terdiri dari 100 responden. Sedangkan metode analisis data menggunakan regresi linier berganda. Hasil penelitian menunjukkan bahwa kemudahan berpengaruh positif dan signifikan terhadap minat pelaku UMKM dalam menggunakan QRIS, sedangkan kepercayaan, manfaat, dan persepsi tidak berpengaruh dan tidak signifikan terhadap minat pelaku UMKM dalam menggunakan QRIS
festivales de ficción televisiva en España como dinamizadores de la industria
Authors: Mateos-Pérez Javier , Sirera Blanco Rebeca
Published: January 2025

Este artículo desarrolla una aproximación al panorama de los festivales españoles especializados en ficción televisiva. Para analizar los datos se propone una metodología mixta: descriptiva y explicativa, que aplica técnicas etnográficas y entrevistas en profundidad, con el objetivo de observar, describir y analizar el contenido y funcionamiento de los cuatro principales festivales que conforman el circuito en España (Serielizados Fest, Conecta Fiction & Entertainment, Iberseries y Platino Industria y South International Series Festival). Los resultados distinguen varias funciones relevantes en estos eventos: la creación de redes y sinergias entre profesionales, la compraventa de obras, la búsqueda de financiación, la formación de creadores y la promoción de series a través de estrenos, coloquios y charlas, que concitan la asistencia de públicos y medios de comunicación. Se concluye que los festivales de ficción televisiva se han convertido en un elemento clave dentro del sector y que contribuyen de forma significativa a la consolidación de la industria en España.
An ’Urf Perspective on the Tradition of Bridal Processions in Weddings: A Case Study of Morocalan Village, Glagah, Lamongan
Authors: Rahmawati Richah , Aminah Siti
Published: January 2025

‘Urf refers to an action or expression that is repeatedly performed, regarded as good, and does not violate sharia principles. Marriage is the bond between a man and a woman, both physically and emotionally, aimed at building a family characterized by sakinah (tranquility), mawaddah (love), and rahmah (compassion). One of the traditions in marriage is the bridal procession, which involves escorting the bride and groom on foot after the wedding ceremony (akad nikah). This study aims to examine the implementation process of the bridal procession and its analysis through the perspective of urf. The research method used is qualitative, employing field research. The findings reveal that the bridal procession in wedding ceremonies in Morocalan Village, Glagah Sub-district, Lamongan Regency, is performed by the groom. The groom is escorted on foot from one end of the village to the bride's house. This tradition serves as an expression of gratitude for the end of bachelorhood and as a way to celebrate the wedding, which is considered a once-in-a-lifetime event. From the perspective of Islamic law and urf, the bridal procession is deemed a legitimate tradition, as it does not contravene Indonesia’s positive law or Islamic principles. Furthermore, this tradition carries positive values for both the bride and groom and their families.
Mechanisms of Action of Dioxin-Like Compounds
Authors: Chen Ao
Published: January 2025

Dioxins are one of the most potent environmental toxins known. They are commonly associated with industrial activities such as waste incineration, pulp bleaching and chemical synthesis processes. Their toxicity stems from the fact that dioxins can activate the aromatic hydrocarbon receptor (AhR), thereby triggering a series of harmful biological responses, including carcinogenicity, immunosuppression, endocrine disruption and reproductive toxicity. Dioxins and their analogues are a growing problem and a major challenge in modern ecology because of their highly chemically stable and heat-resistant structure, their stable chlorinated structure, which makes them difficult to metabolise, resulting in their bioaccumulation in living organisms and persistence in the environment. This research will describe the structure of AhR and the binding mechanism of dioxin and AhR, as well as the metabolic process of PCDD, in order to more accurately predict its potential harm to humans and the environment, and help develop targeted drugs or antidotes to reduce or prevent toxic effects. This research summarizes the new understanding of the mechanism of toxic action of dioxins and their metabolic pathways, which can provide a reference for environmental pollutant screening and risk assessment.
Metabolic kinetics and safety assessment of the antitumor drug meloxicam
Authors: Jiang Xinrui
Published: January 2025

Meloxicam is a selective cyclooxygenase-2 (COX-2) inhibitor with anti-inflammatory effects, and its anti-tumour effects have been the subject of considerable attention in recent years. This research provides a comprehensive analysis of the studies on the anti-tumour aspects of meloxicam, including the mechanism of anti-tumour action, basic pharmacokinetic studies, and an evaluation of the safety profile. The anti-tumour mechanism of meloxicam is primarily characterized by the inhibition of the COX-2/PGE2 signaling pathway, the regulation of apoptosis-related proteins, the inhibition of tumour angiogenesis and the regulation of immune function. In terms of pharmacokinetics, meloxicam has rapid oral absorption, high bioavailability and wide distribution. It is mainly metabolized by the liver, undergoing hydroxylation and oxidation to form biologically inactive metabolites. With an elimination half-life of approximately 20 hours, the safety evaluation is primarily concerned with the assessment of potential gastrointestinal, hepatic, renal and cardiovascular adverse reactions that may arise from long-term use. The application of nanotechnology has the potential to mitigate the observed toxicity).
The Relationship Between Childhood Trauma and Borderline Personality Disorder: The Mediator Effect of Insecure Attachment
Authors: Wang Yilin
Published: January 2025

Childhood trauma is a major cause of borderline personality disorder. Research shows that most patients diagnosed with borderline personality disorder report unhappy or shadowy childhood experiences in psychological assessments. Attachment may be one of the important mechanisms by which childhood trauma affects borderline personality disorder. Attachment styles have a strong influence on people. People with insecure attachment styles often show distrust of others and extreme language and behaviour. This is also a core symptom of borderline personality disorder. The aim of this study was to investigate whether insecure adult attachment styles mediate borderline personality disorder as a result of childhood trauma. In addition, a secure attachment style may have a positive effect on alleviating or even treating Borderline Personality Disorder. This study will investigate this aspect. It is hoped that this research will advance researchers' understanding of the impact of childhood trauma on Borderline Personality Disorder and its mechanisms, and provide theoretical and empirical support for interventions aimed at reducing Borderline Personality Disorder caused by childhood trauma.
Application and Development of Colloidal Gold Labeling Technique
Authors: Wang Jingyao
Published: January 2025

The colloidal gold labeling technique has gained widespread popularity in biomedical research due to its versatility and effectiveness. This technology, which has evolved from the use of fluorescence, radioisotopes, enzymes, and other markers, has emerged as a novel biosensor technology with extensive applications. In recent years, colloidal gold antibody labeling technology has been widely utilized in various fields, including biomedicine, food safety, and environmental protection. Its ability to accurately detect and quantify specific molecules makes it an invaluable tool for researchers. This paper aims to provide a comprehensive review of the development history, technical principles, applications, and advantages of colloidal gold antibody labeling technology. By thoroughly understanding these aspects, researchers can gain insights into how this technology can be further developed and improved for future applications. Moreover, the continued advancement of colloidal gold antibody labeling technology holds great promise for enhancing the early diagnosis of diseases and improving the monitoring of environmental contaminants.
Therapeutic Potential of Berberine
Authors: Chen Zihan
Published: January 2025

Berberine, an alkaloid extracted from plants, is used in the treatment of many diseases, has many pharmacological effects, and is accompanied by a high safety profile, which is popular in drug development and has been applied in many diseases. It shows significant effects on cancer, type 2 diabetes mellitus, gastrointestinal diseases, and cholesterol reduction as the inherent properties of berberine have inhibitory effects on these conditions, some by targeting specific steps in the disease progression, and others by acting directly on the pathogens themselves. Additionally, berberine also has several side effects, and patients should be cautious to avoid exceeding the recommended dosage. Also, it may interact with certain medications, presenting both benefits and risks. Therefore, it is important to take berberine under medical supervision and follow the doctor's advice. This article summarizes several clinical trials, randomized controlled trials, and other experimental studies, including in vivo and in vitro experiments. During this review, it will focus on these four kinds of diseases, to explain the mechanism and description of the relationship between disease and berberine.
Application Performance of Mumps Vaccine in Mumps
Authors: Zheng Zekai
Published: January 2025

Mumps a highly contagious disease, and it is caused by mumps virus. This research analyzed analyzes the research progress of mumps vaccine, and discussed the main problems faced by mumps vaccine. The live attenuated mumps vaccine has been used in most countries and regions for nearly 50 years since its introduction. Although mumps vaccination was able to greatly reduce the incidence of mumps in the past, in recent years there are many cases of mumps around the world, indicating a tendency for mumps disease to recrect. The reason is prolonged use of the mumps vaccine has led to some problems. The main problem is the vaccine is not effective enough, and the immune effect become weaker with time. Because mumps is highly contagious and can cause many very serious sequelae, so it is important to prevent mumps disease. The most useful way to control mumps disease is still mumps vaccine. Changing the injection schedule, increasing the number of injections, and designing new vaccines with other genotypes mumps virus as vaccine strains may solve the main problem faced by the current mumps vaccine.
A Prospective Study on Knee Function Recovery After Total Knee Arthroplasty: A Comparison of Active and Passive Exercise and Pain Assessment
Authors: Liu Yixuan
Published: January 2025

目的： 本研究的目的是确定术后疼痛水平是否降低，并检查主动和被动运动对全膝关节置换术 （TKA） 后膝关节功能恢复的影响。方法： 采用前瞻性研究设计，将我院接受 TKA 的 204 例患者随机分配到连续被动运动 （CPM） 组或受控主动运动 （CAM） 组，每组 102 例患者。两组都接受了两组相同的标准锻炼方案。所有患者在术前、术后和出院后均进行评估。评估指标包括运动范围 （ROM）、西安大略大学和麦克马斯特大学骨关节炎指数 （WOMAC）、视觉模拟量表 （VAS）、膝关节社会功能评分 （KSS） 和简式健康调查 （SF-36）。结果： 术后 1.5 个月和 3 个月，两组屈曲角度差异有统计学意义 （P<0.05）。术后 3 个月和 6 个月，结果显示使用 WOMAC 评分的组疼痛评分存在统计学意义差异 （P<0.05）。其他指标显示两组都有所改善。结论： CAM 组和 CPM 组均显著改善了 TKA 后患者的恢复情况;然而，CAM 组在膝关节屈曲、疼痛缓解和生活质量改善方面表现出卓越的结果。
Research on Computer Technology Empowering Life in Smart Elderly Care Communities
Authors: Liao Tian
Published: January 2025

As the global trend of aging accelerates, smart elderly care has become an important solution for improving the quality of life for older adults. This paper explores the application of computer technology in smart elderly care communities, analyzing how information technology, communication technology, and IoT collectively enhance health management, social interaction, and independence for seniors. Through case studies of multiple smart elderly care communities and supporting statistical data, this paper reveals the significant improvements in quality of life brought by technology to older adults, while discussing the current challenges and future development directions. The research demonstrates that computer technology not only improves the management efficiency of communities but also provides a safer and more convenient living environment for seniors, laying a solid foundation for the development of smart elderly care.
Properties, Detection Mechanism and Applications of AuNPs-Based Sensors in Virus Detection
Authors: Liu Xinye
Published: January 2025

After the outbreak of COVID-19 pandemic, infections caused by viruses have been proved to be one of the greatest global burdens that causes significant morbidity and mortality over the world. Detecting the virus as early as possible can help achieve early diagnosis of the disease. This will help doctors grasp the precious time of treating patients. Therefore, the rapid and accurate detection of viral pathogens is crucial for the effective control in the spreading of diseases, especially during such global pandemics. In the recent years, varies types of gold nanoparticles (AuNPs) based sensors have emerged since AuNPs have shown great potential in the field of viral diagnostics. This review aims to provide an overview of AuNP-based virus detection strategies. It mainly covers the properties of AuNPs, the detection mechanism, and the applications of these methods, such as colorimetric detection, surface plasmon resonance biosensors, fluorescent detection, and electrochemical detection. This work will contribute to promoting the application of AuNPs in virus diagnosis and detection.
Causes and Prevention Measures of Muscle Strain in Track and Field Athletes
Authors: Yin Zhe
Published: January 2025

The incidence of muscle strain is mainly due to the athletes' exercise intensity is large, and the symptoms of muscle strain often appear. According to the combination of the data in this paper, the incidence of muscle strain is high due to the high intensity of athletics and the large physiological load, and the muscle strain is still increasing gradually. Muscle strain will not only affect the athletes' training and competition results, the improper handling will affect the recovery of injured muscle function, and serious disability can be left behind. This paper mainly combines the incidence rate, main occurrence items and main causes of muscle strain caused by universities and athletes, as well as athletes' physical fitness, physical condition, training plan and other issues, to prevent and intervene in muscle strain, so as to reduce the probability of muscle strain of athletes and strengthen coaches' training arrangements and training plans. And to further ensure the health of athletes.
Update on The Risk Factors and Treatment Options for Rheumatoid Arthritis
Authors: Chen Pengyu , Gan Yicheng , Lin Jingxue , Zhao Wanxin
Published: January 2025

Rheumatoid arthritis (RA) is characterized by inflammation of the surrounding joints and tissue hyperplasia, which affect all joints in the body. Although RA is generally not fatal, extrarthral lesions may have adverse consequences, which should be paid enough attention to. At present, the treatment mainly relies on anti-inflammatory, analgesic and immunosuppressive drugs, but the problems of relapse and the adverse drug reactions are still faced. This paper introduces the different high-risk factors of the disease, and the related drug and non-drug intervention measures. At the same time, it expounds the new targets of current treatment, such as psychological intervention, exercise intervention, diet intervention, traditional Chinese medicine intervention, and non-drug intervention assisted by digital remote monitoring. To further reduce the disease progression of RA, and to provide reference for improving the life quality and carrying out continuous care, the problems of the intervention methods were summarized and the prospects for future research were put forward.
Mechanism and treatment methods of cyanide poisoning
Authors: Han Jiarui
Published: January 2025

A powerful toxin, cyanide can be ingested accidentally or on purpose. By attaching to cytochrome oxidase in mitochondria, it prevents ATP synthesis and forces cells into anaerobic metabolism even in the presence of sufficient oxygen. Headache, lightheadedness, and dyspnea are the initial signs of cyanide poisoning, which can escalate to seizures and unconsciousness. Sodium nitrite, sodium thiosulfate, and hydroxocobalamin are effective therapies for cyanide poisoning. Research has demonstrated its effectiveness in human and animal models. However, more studies are needed to confirm its efficiency in various cyanide exposure scenarios. While sodium thiosulfate transforms cyanide into the less poisonous thiocyanate, facilitating detoxification, sodium nitrite causes the synthesis of methemoglobin, which sequesters cyanide from cytochrome oxidase. Studies on animals show that intramuscular injections of sodium thiosulfate and sodium nitrite can effectively reverse the effects of cyanide toxicity and improve lifespan. These countermeasures are essential for both treating and averting the deadly consequences of acute cyanide poisoning. This research will discuss the mechanism of cyanide poisoning and its treatment methods.
Analysis of drug treatment methods for Alzheimer’s disease
Authors: Liu Ruihan
Published: January 2025

Alzheimer’s disease (AD) has attracted attention from scientists since every year thousands of patients are suffering from this. AD, as the primary cause of dementia, holds 60%–80% of all cases and is associated with deficient cholinergic neurotransmission. The path of discovering methods to tackle it is still a long way to go, because there is not such a method to completely heal this disease and as for drugs therapy. There are some drugs including tacrine, donepezil, galantamine and rivastigmine, which are officially being used and are proved to be slightly effective. This research will discuss the etiology of AD, the development of AD related drugs, the functions and dosages of drugs, as well as their advantages and disadvantages. It can be avoided in the early stages, by gaining a better understanding of the current different drug treatment methods and the changes made in the process, in order to improve the efficiency and prediction after fixation, and thus provide direction for the future development of AD drugs.
Immune Checkpoint Inhibitors: Challenges and Potential Strategies
Authors: Ge Tianyu
Published: January 2025

With the rapid development of science and technology, the treatment of cancer is also constantly being upgraded, but the number of cancer patients continues to grow, this has led to an increasing emphasis on such diseases. Therefore, immune checkpoint inhibitors have become the focus of our research today. In tumor cell proliferation, immune checkpoints develop as one of the ways to assist tumor cells in immune escape, so the use of immune checkpoint inhibitors can activate T cells, reduce T cell function exhaustion and inability, and achieve the purpose of killing tumor cells. In recent years, the results of PD-1, PD-L1 and CTLA-4 inhibitors have also been widely used in the treatment of patients, new treatments based on these inhibitors are also emerging. Despite the success of the ICIs in some ways, however, the researchers still found a number of factors that hindered its continued development, for example, research gaps with overall low response efficiency, therefore, new treatments need to be better improved and designed. Consequently, the research topic of this paper is the problems encountered by immune checkpoint inhibitors in this field and their solutions.
Recombinant VSV as a platform for rabies vaccine development: Enhancing immunogenicity and safety
Authors: Zhao Haochen
Published: January 2025

The research investigates the possibility of development of a recombinant vesicular stomatitis virus (VSV) expressing the rabies virus glycoprotein as a novel rabies vaccine. The recombinant VSV can show robust immunogenicity, eliciting strong virus-neutralizing antibody responses in both mice and dogs. The oral vaccine formulation proved stable in simulated gastric conditions and induced immune responses comparable to intramuscular injection. Long-term immunity studies indicated high antibody levels and protection against rabies virus challenge at six months and one-year post-immunization, suggesting potential for durable immunity, particularly in dogs. Toxicity studies can be used to analyze adverse effects, confirming the vaccine’s safety. The potential for the recombinant VSV vaccine to induce mucosal immunity and spread through social behaviours in wildlife populations presents a promising approach for rabies control. However, challenges such as ensuring genetic stability and evaluating environmental impacts must be addressed. This research highlights the recombinant VSV-based vaccine’s promise as an effective, safe, and potentially self-disseminating tool for rabies prevention, with implications for both human and veterinary applications.
Tumor Immune Microenvironment and Its Regulatory Mechanism
Authors: Yuan Yue
Published: January 2025

Gastric cancer (GC) is a highly heterogeneous tumor, and TME plays a key role in tumorigenesis and progression. TME is composed of immune cells, CAF and ECM, which regulate the growth, invasion and metastasis of GC through complex interactions. Immune escape mechanisms, such as the activation of the PD-1/PD-L1 pathway, weaken the body's anti-tumor immune response and lead to further proliferation of tumor cells. In addition, high density of immunosuppressive cells and active CAF are strongly associated with poor prognosis in patients with GC. In recent years, targeted therapeutic strategies for TME, such as immune checkpoint inhibitors (ICIs), CAF inhibitors, and ECM remodeling modulators, have shown potential therapeutic effects and become a new way to improve the survival rate of GC patients. However, due to the complexity and heterogeneity of TME, future studies still need to further explore the specific mechanism of action of TME in different stages of GC, and develop more accurate personalized treatment plans. Multidisciplinary combined treatment strategies are expected to play an important role in improving the prognosis of patients with GC.
Progress of Ginsenosides on Immunomodulation and Inhibition of Lung Cancer
Authors: Wei Dongju
Published: January 2025

Ginseng is characterized by low toxicity, multi-targeting and enhancement of body immunity in its anti-cancer effects. Ginsenosides are natural effective anti-cancer components, mainly consisting of diol-type, triol-type, and oleanolic acid-type ginsenosides. Ginsenosides are bio absorbed by intestinal flora through "Rb1-Gibberellin XVII-F2-CK-PPD", "Rb2-Rd-F2-CK-PPD", "Rg3-Rh2-PPD" and other pathways. It can be converted into saponins ck, Rh1, Rh2, Rc, PPD and other active ingredients.  Metabolites of ginsenosides are used in the treatment of many types of cancers and have been shown to be effective. They function by modulating various immune cells in the body, for example, ginsenoside Rh2 significantly increases T-lymphocyte activity and significantly induces differentiation of M2 macrophages towards the M1 phenotype. Ginsenoside Rg3 can act as a cytotoxic activator of NK cells, which inhibits the growth of tumor cells and induces apoptosis and autophagy of tumor cells, and plays an inhibitory and therapeutic role in lung cancer and a variety of tumors, with certain prospects for application development. This review introduces mechanism and function of ginsenosides and discusses application in lung cancer.
Influence of Myeloid-derived Suppressor Cells in Tumor Immunotherapy
Authors: Yu Yang
Published: January 2025

The immunosuppressive response of myeloid-derived suppressor cells (MDSCs) in tumor microenvironment (TME) has become an important area of tumor research. Among them, arginase 1 (ARG1), as a key immunosuppressive molecule in MDSCs, inhibits T cell function by consuming L-arginine, producing polyamines and secreting immunosuppressive cytokines, thereby promoting tumor immune escape. This article first briefly introduces the background and mechanism of action of MDSCs, and then systematically summarizes and analyzes the fine regulation of ARG1 expression by multiple factors, including transcriptional, epigenetic and post-translational mechanisms, and its specific role in MDSCs and its regulatory mechanism. Finally, the research progress of ARG1 as a potential therapeutic target is summarized, such as the development and application of ARG1 inhibitors, and the mechanisms of action and advantages and disadvantages of several different research methods are analyzed. A promising small molecule inhibitor CB-1158 and future prospects are understood, and the therapeutic direction and possible solutions for future research are proposed.
Immune Escape and Immune Checkpoint-associated Therapies in the Tumour Microenvironment of Head and Neck Squamous Cell Carcinoma
Authors: Yang Qinzhi
Published: January 2025

Head and neck squamous cell carcinoma (HNSCC) comprises a prevalent category of malignant neoplasms that present as oropharyngeal, oral cavity, laryngopharyngeal, hypopharyngeal, and laryngeal cancers. Each year, close to a million people around the globe find themselves grappling with these fierce and relentless cancers. Addressing HNSCC often requires a multifaceted approach, ranging from surgical intervention and radiation to chemotherapy, immunotherapy, or a blend of these treatments. Nonetheless, the five-year survival rate for HNSCC persists at fifty percent overall and has not exhibited substantial improvement in recent years. Prior research has demonstrated that the tumor microenvironment (TME) significantly influences recurrence, metastasis, and drug resistancein individuals with HNSCC. This review outlines the roles of both anti-tumor and pro-tumor immune cells, as well as the extracellular components of the tumor microenvironment (TME) in head and neck squamous cell carcinoma (HNSCC).The discussion encompasses classical immunotherapies for HNSCC, the molecular pathogenesis of HNSCC, the tumor microenvironment in HNSCC, and the mechanisms through which HNSCC cells evade immune surveillance. The paper highlights several clinical trials that focus on using CTLA-4 inhibitors alongside combination therapies involving programmed cell death protein 1 (PD-1) and its ligand, PD-L1. As well as looking forward to some potential therapeutic approaches in clinical care that are expected to provide new strategies for clinical treatment.
Treating Treatment-Resistant Obsessive-Compulsive Disorder (OCD) via Deep Brain Stimulation (DBS)
Authors: Wong Wing Hei
Published: January 2025

Obsessive-Compulsive Disorder (OCD) is a prevalent and challenging mental health condition characterized by persistent, unwanted thoughts (obsessions) and repetitive behaviors (compulsions). Traditional treatment modalities, including pharmacotherapy and cognitive-behavioral therapies, fail to alleviate symptoms in around half of the patients, necessitating the exploration of alternative therapeutic options. Deep Brain Stimulation (DBS) has emerged as a promising intervention for treatment-resistant OCD, with recent studies reporting a success rate of about 60%. This innovative treatment involves the precise placement of electrodes in specific brain regions such as the Nucleus Accumbens (NAcc), Bed Nucleus of the Stria Terminalis (BNST), and Subthalamic Nucleus (STN) to modulate dysfunctional neural circuits. This paper reviews the effectiveness of DBS in reducing OCD symptoms, evaluates its safety, and discusses the neurobiological mechanisms underlying its therapeutic effects. It also explores future research directions, including the optimization of electrode placement, the integration of DBS with other treatment modalities, and the development of personalized medicine approaches. Furthermore, the paper addresses ongoing challenges such as the need for a clearer understanding of DBS mechanisms, the refinement of patient selection criteria, and the management of long-term outcomes. By providing a comprehensive overview of current knowledge and potential developments, this study aims to highlight the role of DBS as a transformative tool for managing severe, refractory OCD.
CD8+T Cell Exhaustion and Immune Checkpoint Blockade Treatment
Authors: Song Jiani , Yuan Quan , Zhou Yuxin
Published: January 2025

T cells play an important role in anti-tumor immunity. Its subset that contains the surface receptor CD8, also called cytotoxic T cells, functions to facilitate tumor cell elimination. Chronic exposure of CD8+ T cells to antigens and inflammation can cause the T cells to lose their functions as well as changes in their surface expressions, named T cell exhaustion (Tex). This article reviews the molecular mechanisms of this cellular process and the influence of the tumor microenvironment (TME) on it. This article focuses on the mechanism of action of the four major upregulated immune checkpoint proteins (ICPs) and introduces ICB therapies targeting each ICP. Based on these mechanisms, scientists have suggested various interventions to reverse T-cell exhaustion. Recent clinical data show that although ICB therapy has significant efficacy in some patients, its limitations in patient selection limit the popularization of the treatment effect. ICB which curbs Tex by blocking the signal pathways that suppress T cell functions, summarizes the current understandings and progress, and identifies the gaps on this topic.
Polarization State of Macrophages Under Lactate Action
Authors: Li Sixuan
Published: January 2025

As the most prevalent immunological population in the tumor microenvironment (TME), tumor associated macrophages (TAMs) are crucial to TME. Simultaneously, acidic environment is a prominent feature in TME. Recent studies have shown that macrophages undergo further division into two distinct types of TAMs, namely M1 and M2, respectively. They are induced by different inducing factors and play different roles in cancer and inflammation. Lactic acid strongly enhances the transformation of macrophages with M1 designation into macrophages with the M2 designation, as shown by the increased expression of M2 genes. This article analyzes EC lactate and obtains the results of its transportation in the form of MCT1 lactate transporter. There is also an epigenetic mechanism that promotes macrophage polarization. Using lactate as a target, MCT1 inhibitor AZD3965 can inhibit the expression of M2 macrophages. Because it only discusses lactic acid in acidic environments, it has limitations. This article provides reference for future research on lactate, and the specific mechanism of action of HIF-1 α in lactate environment has not been resolved. Future research can focus on this direction.
Inflammatory Mechanisms and Treatments of Alzheimer's Disease: An Integrative Review of Neuroscience and Bioinformatics
Authors: Li Bangyu
Published: January 2025

The most common type of dementia, Alzheimer's disease (AD), is characterized by plaques of amyloid-beta (Aβ) and then tangles of tau protein aggregating in the brain, causing neurodegeneration and cognitive decline. The association between neuroinflammation and the pathogenesis of AD has come to be increasingly well acknowledged. This review discusses the inflammatory pathways involved in AD, focusing on microglia and astrocytes, as well as the involvement of various proinflammatory cytokines (i.e., TNF-α and IL-1β). The NF-κB signaling and the NLRP3 inflammasome are also reviewed for their effects on neuronal death and cognitive dysfunction. Additionally, the unifying function of bioinformatics in AD research, combining genomic and transcriptomic analyses with proteomics and metabolomics, is explored. These tools have uncovered crucial genetic and molecular pathways associated with inflammatory cross-talks in AD, revealing possible drug targets. An overview of treatments such as nonsteroidal anti-inflammatory drugs (NSAIDs), immunotherapies, and newer therapies like stem cell therapy and RNA interference is provided, along with their efficacy and drawbacks. The review concludes by highlighting the importance of multidisciplinary approaches and individualized therapies to enhance therapeutic outcomes in AD patients.