bluuebunny/crossref_metadata_2025 huggingface dataset:
Pela vontade de Ahura Mazdā. Morte, monumentalidade e memória na necrópole aquemênida de Naqš-e Rostam
Authors: Vieira Pinto Otávio Luiz
Published: January 2023

Este artigo objetiva compreender o papel político, religioso e simbólico das tumbas aquemênidas (século VI AEC – IV AEC) na necrópole de Naqš-e Rostam. A existência destes mausoléus indica que os governantes aquemênida decidiram não seguir a “ortodoxia zoroastrista” (a religião que possivelmente era professada pelos persas neste período), que estipulava um rito funerário baseado na escarnação do cadáver e não previa a cremação, o enterramento ou a construção de túmulos. Assim, é possível argumentar que as tumbas de Naqš-e Rostam foram projetadas como monumentos de cunho político e propagandístico, e não possuíam uma função unicamente espiritual. A análise desta necrópole levará em consideração o conceito de tecnologia de memória no contexto histórico iraniano, como proposto por Matthew Canepa, e a abordagem não-essencialista do zoroastrismo a partir de Philip Kreyenbroek. A partir deste trabalho investigativo conclui-se que, entre os aquemênidas, a monumentalização da morte visava criar uma memória atemporal da autoridade persa.
A naenia no funeral: revisitando o famoso relevo de Amiternum
Authors: Beltrão Claudia , Feitosa Paulo Márcio
Published: January 2023

Entre as figuras do relevo de Amiternum, há um pequeno grupo de mulheres enlutadas, provavelmente contratadas e ligadas ao lucus dos agentes funerários, os libitinarii. Este artigo perguntará por essas profissionais e pelo significado da canção que elas entoavam no funeral, a naenia, a partir deste documento ímpar sobre um funeral romano. Não há nenhuma fonte que proveja dados seguros sobre a sequência ritual, e apresenta-se aqui uma hipótese de leitura do significado religioso da naenia. Referências literárias alusivas e esparsas, interpretações modernas e a iconografia do relevo são fundamentais para qualquer tentativa de reconstrução do significado da naenia.
Morte e o morrer dos homens santos, dos amantes e dos políticos nos folhetos de literatura de Cordel
Authors: Santos Paula Cristiane de Lyra
Published: January 2023

A resenha apresenta a obra intitulada Loas que carpem: a morte na literatura de cordel, de autoria de Marinalva Vilar de Lima. Esta obra trata a temática da morte e do morrer, dos homens santos, dos amantes e dos políticos a partir de um amplo corpus de cordeis que foram analisados com o objetivo de identificar como se dá a percepção da morte e do morrer nestas obras literárias. Algumas conclusões se destacam mas duas delas são bastante importantes. A primeira é que a mentalidade dos produtores de cordeis é influenciada por um catolicismo de cunho conservador, e a segunda que a morte e o morrer são parte da vida das comunidades que consomem os cordeis, que a vivem de uma forma comunitária, e a experienciam em seus cotidianos, e as cosomem em obras literárias .
Engineering global regulators for enhanced tolerance to multiple inhibitors by CRISPR‐enabled trackable genome engineering
Authors: Song Xin , Zheng Yangyang , Li Shuting , Choudhury Alaksh , Liu Xunli , Chen Tao , Gill Ryan T. , Wang Zhiwen
Published: January 2023

Strain engineering for industrial production requires the improvement of tolerance to multiple unfavorable conditions. Here, we report global regulator libraries based on the CRISPR‐enabled trackable genome engineering to engineer tolerance against multiple inhibitors in Escherichia coli. Deep mutagenesis libraries were rationally designed, and constructed to target 34,340 mutations across 23 global regulators. Sixty‐nine specific mutations, respectively, conferred tolerance to acetate, NaCl, furfural, and high temperature were isolated, confirmed, and evaluated. Among them, 31 novel reconstructed mutations exhibited better tolerance to the corresponding inhibitors. The most dramatic mutation CRP‐E182D conferred high cross‐tolerance to acetate, NaCl, and isobutanol. According to the reconstruction and transcriptome analysis, the tolerance of mutant strains to acetate is a complex whole‐cell process. In particular, it was confirmed for the first time that upregulation of ilvA and nadA‐pnuC, deletion of potF or the small RNA sgrS, and adding exogenous valine or isoleucine significantly increased acetate tolerance.
Designing minimally segregating granular mixtures for gravity‐driven surface flows
Authors: Duan Yifei , Peckham Jack , Umbanhowar Paul B. , Ottino Julio M. , Lueptow Richard M.
Published: January 2023

In dense flowing bidisperse particle mixtures varying in size or density alone, smaller particles sink (percolation‐driven) and lighter particles rise (buoyancy‐driven). But when particle species differ from each other in both size and density, percolation and buoyancy can either enhance (large/light and small/heavy) or oppose (large/heavy and small/light) each other. In the latter case, a local equilibrium can exist in which the two mechanisms balance and particles remain mixed: this allows the design of minimally segregating mixtures by specifying particle size ratio, density ratio, and mixture concentration. Using DEM simulations, we show that mixtures specified by the design methodology remain relatively well‐mixed in heap and tumbler flows. Furthermore, minimally segregating mixtures prepared in a fully segregated state in a tumbler mix over time and eventually reach a nearly uniform concentration. Tumbler experiments with large steel and small glass particles validate the DEM simulations and the potential for designing minimally segregating mixtures.
Bilayer Bending Actuators Based on Semicrystalline Polyurethanes with Large Thermal‐Expansion Coefficients
Authors: Muff Livius F. , Weder Christoph
Published: January 2023

Thermoresponsive polymer‐based bilayer bending actuators rely on the dissimilar thermal expansion of the polymers that form the two layers. To maximize the heat‐induced change in curvature, the thermal expansion shall be large in one and small in the other material. Semicrystalline polymers display a large nonlinear thermal expansion across their melting transition, but as their mechanical integrity is lost upon melting, they cannot readily be used in bilayer actuators. To overcome this limitation, segmented polyurethanes (PUs) with crystallizable polyethylene glycol (PEG) soft segments and hard segments formed by the reaction of 1,6‐hexane diisocyanate and 1,4‐butanediol (BDO) is developed. The latter serve as physical cross‐links and inhibit flow at temperatures where the domains formed by the PEG segments have melted. The molecular weight of the PEG segments and the hard‐segment content in the polymer are systematically varied. As the nonlinear expansion of the PEG–PUs is associated with the melting of the crystalline PEG domains, the thermal expansion of these materials is correlated with their crystallinity and is highest for the polymers with the lowest BDO content and the highest PEG molecular weight. Electro‐thermally controlled bilayer bending actuators based on the new materials display high deflection and low switching temperatures.
Some orangutans acquire enamel defects at regular intervals, but not according to seasonal cycles
Authors: O'Hara Mackie C. , McGraw W. Scott , Guatelli‐Steinberg Debbie
Published: January 2023

Objectives

Developmental defects of tooth enamel are associated with systemic physiological stress and have been linked to seasonal environmental factors such as rainfall, temperature, and fruit availability. Here, we evaluate whether linear enamel hypoplasia and accentuated perikymata occur with any cyclicity on lower canines and then whether cycles differ between Bornean and Sumatran orangutans.

Materials and Methods

Epoxy casts of lower canines from Pongo abelii (n = 14) and P. pygmaeus (n = 33) were evaluated for perikymata and dental enamel defects. Individual developmental sequences (IDSs) were generated for each canine, tracking the position of each defect in the context of continuous perikymata (time). Autocorrelation, a form of time‐series statistical analysis was run for each canine to identify whether any cyclicity of defect expression was discernable.

Results

Autocorrelation revealed cycles of defect expression within canines, but no common cycle periodicities were identified between individuals of the same species or across species. P. pygmaeus averaged more linear enamel hypoplasia per year than P. abelli, but no other comparisons (number of defects, number of perikymata between defects, and autocorrelation analysis) revealed differences between the species.

Discussion

Although no common patterns of defect expression were identified within or between P. abelli and P. pygmaeus, the potential for autocorrelation analysis is promising for primatological and paleoanthropological studies of seasonal phenomena.
Novel neodymium complex on MCM‐41 magnetic nanocomposite as a practical, selective, and returnable nanocatalyst in the synthesis of tetrazoles with antifungal properties in agricultural
Authors: Moradi Parisa , Zarei Batool , Abbasi Tyula Yunes , Nikoorazm Mohsen
Published: January 2023

This project reports a simple procedure for the synthesis and characterization of neodymium on MCM‐41 magnetic nanoparticles (MNPs) as a reusable nanocatalyst. First, magnetite (Fe3O4) MNPs were prepared by chemical co‐precipitation procedure from FeCl3 hexahydrate and FeCl2 tetrahydrate in basic NH3 solution. At the second step, MCM‐41 magnetic nanocomposite (MCM‐41 MNC) was prepared by Fe3O4 doping into mesoporous MCM‐41 channels. At the third step, a novel neodymium Schiff base complex was immobilized on MCM‐41 MNC. At the fourth step, this catalyst (Nd‐LArg‐5BrSalen@MNC) was used as practicable and magnetically recoverable nanocatalyst in the homoselective synthesis of tetrazoles. This nanocatalyst was characterized via several analysis, for example, TGA, TEM, UV, SEM, FT‐IR, SEM‐EDS, VSM, ICP, XRD, WDX, and BET. All tetrazole products were synthesized with high yield in a short time. Despite high catalytic activity of neodymium, it has rarely used as a catalyst in the synthesis of organic compounds. All synthesized organic compounds were identified by 1H NMR, FT‐IR, and physical properties. Nd‐LArg‐5BrSalen@MNC nanocatalyst displays high activity, good selectivity, stability, and more important facile magnetic separation. Nd‐LArg‐5BrSalen@MNC nanocatalyst can be isolated and used again for several times consecutively without considerable loss of its catalytic activity. The recycled catalyst was characterized by SEM, EDS, WDX, XRD, and FT‐IR techniques and showed a good match with the fresh catalyst. Also, the antifungal activity of the some tetrazole derivatives was studied against Fusarium oxysporum (rot disease of chickpea root) and Botrytis cinerea (gray mold of strawberry) using the paper disk method on PDA culture medium.
Pyridine derivatives complexes of Co(II) and Ni(II) 3‐bromobenzoates: Crystal structure, in silico anti‐SARS‐CoV‐2 potential, serum albumin binding properties and cytotoxicity
Authors: Öztürkkan Füreya Elif , Özdemir Mücahit , Akbaba Giray Buğra , Sertçelik Mustafa , Yalçın Bahattin , Şahin Ertan
Published: January 2023

Two mononuclear [Co(3‐BrBA)2(NA)2(H2O)2] (1) and [Ni(3‐BrBA)2(3‐CNPY)2(H2O)2] (2) (3‐BrBA = 3‐bromobenzoate, NA = pyridine‐3‐carboxylic acid, and 3‐CNPy = 3‐cyanopyridine) were synthesized and characterized by single crystal X‐ray diffraction, elemental analysis, and FT‐IR spectroscopy. In both complexes, the metal atom is coordinated by two oxygen atoms of two carboxylate anions, two nitrogen atoms of two pyridine rings, and two oxygen atoms of two water molecules in the distorted octahedral environment. Intermolecular interactions were examined with the help of the 3D Hirshfeld surfaces and 2D fingerprint plots. With the help of density functional theory (DFT) studies, besides verifying the experimentally obtained structural properties, the electronic energies, polarizability, dipole moments, ionization potentials, electron affinities, electronegativity, chemical hardness, global softness, electrophilic indexes, HOMO‐LUMO orbitals, and band gaps were also calculated. In vitro cytotoxic activity of the complexes on primary peripheral blood mononuclear cells were evaluated using the MTT assay. Fluorescence quenching techniques and molecular docking studies were used to investigate the interaction between bovine serum albumin (BSA) and the complexes. The molecular docking study has been used to explain the interaction of complexes with spike proteins of beta variant (B.1.351), gamma variant (P.1), delta variant (B.1.617.2), kappa variant (B.1.617.1), and omicron variant (B.1.1.529) of coronavirus. Additionally, the pharmacokinetic and toxicological properties of the complexes have been computed using the SwissADME and ProTox‐II online databases, respectively.
Dual mode stimuli‐responsive color‐tunable transparent photoluminescent anticounterfeiting polycarbonate electrospun nanofibers embedded with lanthanide‐doped aluminate
Authors: Alatawi Nada M. , Alkhamis Kholood M. , Munshi Alaa M. , Althagafi Ismail , El‐Metwaly Nashwa M.
Published: January 2023

Photochromism has been used as an attractive method to enhance the authentication of commercially available goods. It has been fundamental to enhance the engineering procedure of the authentication materials to introduce a mechanically reliable authentication nanofibrous film. In this context, we develop a mechanically reliable and photoluminescent electrospun nanofibrous polycarbonate film immobilized with lanthanide‐doped aluminate nanoparticles (NPs) by the electrospinning method for authentication purposes. The prepared composite film displayed photochromism by changing color from transparent under daytime light to green under ultraviolet light. To guarantee the transparency of the electrospun nanofibrous film, the strontium aluminate pigment must be presented in the nano‐scaled particle form to improve its distribution without forming aggregates in the electrospun polycarbonate nanofibrous bulk. The pigment‐polycarbonate nanofibers showed an emission band at 512 nm upon excitation at 374 nm. The pigment‐polycarbonate nanofibers showed an improved hydrophobicity with raising the pigment ratio without adverse influences on their inherent appearance and mechanical characteristics. When excited with UV light, the transparent films had rapid and reversible photochromism without fatigue. The nanofibrous mats displayed elasticity and flexibility. The present approach can be described as a competent method for the preparation of diverse anticounterfeiting materials.
Facile synthesis of intrinsically flame‐retardant epoxy thermosets with high mechanical properties from lignin derivatives
Authors: Chen Jituo , Zhang Yuxiang , He Feng , Ying Jun , Li Shi‐Neng , Peng Li , Wu Qiang , Fan Zhiqiang , Jiang Baiyu
Published: January 2023

Preparing bio‐based epoxy resins with high performance is crucial to sustainable development. However, seeking renewable and flame‐retardant epoxy resins with high mechanical properties are still challenging. Here, we reported a facile way to transform lignin derivatives to intrinsic flame‐retardant epoxy resins with satisfactory mechanical properties. Two guaiacol‐based novolac epoxy resins (i.e., GTEP/DDM and GPEP/DDM) were prepared as alternatives for petroleum‐based DGEBA/DDM. The cured GTEP/DDM product showed a high Tg of 209.5°C, a high tensile modulus of 3.13 GPa, and a high LOI of 28.6% with UL‐94 V‐1 rating, which outperformed DGEBA/DDM system. Specially, GPEP/DDM resin possessed more superior mechanical properties (e.g., tensile strength of 73.9 MPa, and tensile modulus of 5.85 GPa) owing to additional interactions (i.e., π–π interactions and hydrogen bonds), and outstanding anti‐flammability (e.g., LOI of 31.2% with UL‐94 V‐0 rating) due to the endow of phosphorus‐containing groups. The mechanical reinforcement and flame‐retardant mechanisms were clarified based on structural evolution and performance variation. This work provides an efficient synthesis route to achieve a high‐performance thermoset, which is a promising alternative for substituting conventional bisphenol‐A epoxy resin for use as fireproof materials.
Preparation and performances of a cationic modified polyacrylamide viscosity enhancer for water‐based drilling fluids
Authors: Zhang Qin , Wang Qingchen , Sun Huan , Zhu Mingming , Wei Yan , Kang Xue
Published: January 2023

Polyacrylamide and its derivatives are commonly used as viscosity enhancers in water‐based drilling fluids, but they have limitations in terms of salt resistance and temperature resistance. In this study, a novel cationic functional monomer, 4‐allylaminocarbonyl‐1‐dodecylpyridinium bromide, was introduced into the molecular chains of an acrylamide and acrylic acid copolymer in order to improve its temperature resistance and salt tolerance. Results showed that the apparent viscosity of a 2000 mg/L copolymer solution was 440.4 mPa s at a shear rate of 7.34 s−1, decreasing to 23.5 mPa s at 510 s−1 before recovering to 49.2 mPa s when the shear rate returned to 170 s−1. After 16 h of aging at 120°C, a brine drilling fluid containing 1% of the copolymer showed an apparent viscosity retention rate of 70%, likely due to the formation of a stable net structure between the copolymer's molecular chains and clay particles. These results suggest that the copolymer could be an excellent candidate for use as a viscosity enhancer in drilling fluids.
On the ontological ambiguity of physics facing reality
Authors: Horvath Jorge E. , Fernandes Rodrigo Rosas , Idiart Thais E.
Published: January 2023

We discuss in this work, the contradictory position in modern Physics between the existence of a microphysical quantum reality and macrophysical classical one. After discussing some basic concepts in Philosophy, we revisit the situation of Quantum Mechanics results, particularly after the confirmation of violations of Bell's theorem, and its significance to create a tension between the micro and the macro world, which is very fundamental and unsolved.
The influence of deceleration and internal structure on the braking index of pulsars: Simplest model for the star
Authors: da Silva Bortoli Fabio , Garcia Natan Vanelli , Magalhaes Nadja Simao , Frajuca Carlos
Published: January 2023

Pulsars are rotating neutron stars whose electromagnetic radiation is observed to pulsate and, despite the extremely stable rates, the frequencies of the pulses decay with time, as quantified by the braking index (n). It is extremely difficult to obtain this index from observations due to different factors. Theoretically, in the canonical model for neutron stars, one finds n = 3, but observational data shows that n is less than three. In this work, the canonical model is modified, incorporating the influence of the deceleration of the neutron star. As the star's rotation decelerates, the deformation of the star due to the centrifugal force decreases thereby reducing its moment of inertia. Consequently, the star decelerates less, reducing the braking index. In this work, the star is modeled as a very hard, compressible spherical shell filled with neutrons and protons superfluid that do not interacts with the shell. Using this toy model as a first approach, the braking index is found as a function of rotation, yielding a theoretical braking index closer to the one derived from observational data.
Additional oncological benefit of photodynamic diagnosis with blue light cystoscopy in transurethral resection for primary non‐muscle‐invasive bladder cancer: A comparative study from experienced institutes
Authors: Miyake Makito , Nishimura Nobutaka , Nakahama Tomonori , Nishimoto Koshiro , Oyama Masafumi , Matsushita Yuto , Miyake Hideaki , Fukuhara Hideo , Inoue Keiji , Kobayashi Keita , Matsumoto Hiroaki , Matsuyama Hideyasu , Fujii Tomomi , Hirao Yoshihiko , Fujimoto Kiyohide
Published: January 2023

Objectives

The objective of this work is to evaluate the additional oncological benefit of photodynamic diagnosis (PDD) using blue‐light cystoscopy in transurethral resection (TURBT) for primary non‐muscle‐invasive bladder cancer (NMIBC) based on the International Bladder Cancer Group (IBCG)‐defined progression and the subsequent pathological pathways.

Patients and Methods

We reviewed 1578 consecutive primary NMIBC patients undergoing white‐light TURBT (WL‐TURBT) or PDD‐TURBT during 2006–2020. One‐to‐one propensity score‐matching was performed using multivariable logistic regression to obtain balanced groups. IBCG‐defined progression of NMIBC included stage‐up and grade‐up as well as conventional definitions such as the development of muscle‐invasive BC or metastatic disease. Nine oncological endpoints were evaluated. Sankey diagrams were generated to visualize follow‐up pathological pathways after the initial TURBT.

Results

Comparison of event‐free survival between the matched groups revealed that PDD use decreased the bladder cancer recurrence risk and IBCG‐defined progression risk, whereas no significant difference was noted in conventionally defined progression. This was attributable to a reduced risk of stage‐up, from Ta to T1, and grade‐up. Sankey diagrams of the matched groups showed that patients with primary Ta low‐grade tumour and first‐recurrence Ta low‐grade tumour did not have bladder recurrence or progression, while some of those in the WL‐TURBT group developed recurrence after treatment.

Conclusions

The multiple survival analysis demonstrated that the risk of IBCG‐defined progression was significantly decreased by PDD use in NMIBC patients. Sankey diagrams revealed possible differences in pathological pathways after the initial TURBT between the two groups, demonstrating that repeated recurrence could be prevented by PDD use.
Regional distributions of curcumin and tetrahydrocurcumin in the liver and small intestine of rats when orally co‐administered with quercetin and paeoniflorin
Authors: Yu Weilan , Liu Xiaolin , Cai Dake , Zheng Juntao , Lao Biaochang , Huang Min , Zhong Guoping
Published: January 2023

Curcumin (CUR), derived from the dietary spice turmeric, is a polyphenolic compound with various biological and pharmacological activities. Tetrahydrocurcumin (THC) is one of the major reductive metabolites of curcumin. A pharmacokinetic study using ultra‐high‐performance liquid chromatography‐tandem mass spectrometry (UHPLC‐MS/MS) for the simultaneous determination of curcumin, THC, quercetin (QR), and paeoniflorin (PF) in rat plasma had been performed. In this study, the regional distributions of curcumin and tetrahydrocurcumin in the liver and the three segments of small intestine (duodenum, jejunum, and ileum) of rats when orally co‐administered with quercetin and paeoniflorin were carried out. Drug concentrations were determined using UHPLC‐MS/MS. The results showed that curcumin was well distributed in the small intestine, while the distributions of tetrahydrocurcumin in the liver, duodenum, jejunum were similar, but much more abundant in the ileum. When orally co‐administered with quercetin and paeoniflorin, the tissue to plasma concentration ratios (Kp values) of curcumin in the three segments of the small intestine were increased, indicating that the presence of quercetin and paeoniflorin increases the distribution of curcumin in these regions. Moreover, the half‐life (t1/2) of THC in the liver was significantly prolonged, and the Kp value of THC in the liver was increased and the Kp values in the small intestine were decreased, suggesting that the combination of quercetin and paeoniflorin might suppress the metabolism of curcumin in the small intestine. In brief, the combination had an effect on the distributions of curcumin and tetrahydrocurcumin in the liver and small intestine of rats.
Behavioral outcome of very preterm children at 5 years of age: Prognostic utility of brain tissue volumes at term‐equivalent‐age, perinatal, and environmental factors
Authors: Liverani Maria Chiara , Loukas Serafeim , Gui Laura , Pittet Marie‐Pascale , Pereira Maricé , Truttmann Anita C. , Brunner Pauline , Bickle‐Graz Myriam , Hüppi Petra S. , Meskaldji Djalel‐Eddine , Borradori‐Tolsa Cristina
Published: January 2023

Objective

Prematurity is associated with a high risk of long‐term behavioral problems. This study aimed to assess the prognostic utility of volumetric brain data at term‐equivalent‐age (TEA), clinical perinatal factors, and parental social economic risk in the prediction of the behavioral outcome at 5 years in a cohort of very preterm infants (VPT, <32 gestational weeks).

Methods

T2‐weighted magnetic resonance brain images of 80 VPT children were acquired at TEA and automatically segmented into cortical gray matter, deep subcortical gray matter, white matter (WM), cerebellum (CB), and cerebrospinal fluid. The gray matter structure of the amygdala was manually segmented. Children were examined at 5 years of age with a behavioral assessment, using the strengths and difficulties questionnaire (SDQ). The utility of brain volumes at TEA, perinatal factors, and social economic risk for the prediction of behavioral outcome was investigated using support vector machine classifiers and permutation feature importance.

Results

The predictive modeling of the volumetric data showed that WM, amygdala, and CB volumes were the best predictors of the SDQ emotional symptoms score. Among the perinatal factors, sex, sepsis, and bronchopulmonary dysplasia were the best predictors of the hyperactivity/inattention score. When combining the social economic risk with volumetric and perinatal factors, we were able to accurately predict the emotional symptoms score. Finally, social economic risk was positively correlated with the scores of conduct problems and peer problems.

Conclusions

This study provides information on the relation between brain structure at TEA and clinical perinatal factors with behavioral outcome at age 5 years in VPT children. Nevertheless, the overall predictive power of our models is relatively modest, and further research is needed to identify factors associated with subsequent behavioral problems in this population.
Transcatheter aortic valve implantation in patients with anomalous coronary artery
Authors: Bajoras Vilhelmas , Diečkus Laurynas , Wong Ivan , Laurinavičienė Anna , Davidavičius Giedrius , Čėsna Sigitas
Published: January 2023

Objectives

The aim of this review was to analyze literature and provide systematic algorithm to guide decision making during TAVI procedure.

Background

Transcatheter aortic valve implantation (TAVI) is growing in popularity and expanding to younger patients with lower risk profiles. Currently, there is no concise guideline on the management strategy during TAVI in patients with anomalous coronary artery (ACA) anatomy undergoing this procedure.

Methods

A systematic search was conducted for relevant case reports of TAVI in patients who had confirmed ACA anatomy. Twenty‐four case reports, that met the criteria for this review, were identified and included in the final study size.

Results

TAVI was successful in 23 out of 24 cases. Half of the cases (12) described performing balloon aortic valvuloplasty (BAV) before TAVI. The majority (15) reported using angiogram Postimplantation. Only one‐third of cases (8) reported performing coronary protection (with either wire, wire and stent or wire and balloon). Two‐third of case reports (16/24, 67%) mentioned using Edwards SAPIEN balloon expandable transcatheter heart valves (THV).

Conclusions

Preprocedural diagnostic imaging tests play important role in determining the ACA anatomy and its relation to the aortic valve. BAV with simultaneous coronary arteries angiography or aortography should be performed before implantation of THV, as it could potentially predict whether the ACA would be compressed. Using at least a coronary wire for ACA protection is recommended in case there is high risk of ACA obstruction. Management strategy should be individualized when performing TAVI in patients with ACA.
Singlet Oxygen Responsive Molecular Receptor to Modulate Atropisomerism and Cation Binding
Authors: Bouteille Quentin , Sonet Dorian , Hennebelle Marc , Desvergne Jean‐Pierre , Morvan Estelle , Scalabre Antoine , Pouget Emilie , Méreau Raphaël , Bibal Brigitte
Published: January 2023

In switchable molecular recognition, 1O2 stimulus responsive receptors offer a unique structural change that is rarely exploited. The employed [4+2] reaction between 1O2 and anthracene derivatives is quantitative, reversible and easily implemented. To evaluate the full potential of this new stimulus, a non‐macrocyclic anthracene‐based host was designed for the modular binding of cations. The structural investigation showed that 1O2 controlled the atropisomerism in an on/off fashion within the pair of hosts. The binding studies revealed higher association constants for the endoperoxide receptor compared to the parent anthracene, due to a more favoured preorganization of the recognition site. The fatigue of the 1O2 switchable hosts and their complexes was monitored over five cycles of cycloaddition/cycloreversion.
Fluorinated Dihydropentalene‐1,4‐Dione: A Strong Electron‐Accepting Unit with Organic Semiconductor Characteristics
Authors: Yokoyama Soichi , Ie Yutaka
Published: January 2023

The development of electron‐accepting units is of significant importance because the construction of donor (D)‐acceptor (A) configurations is an effective strategy for tuning the electronic properties of π‐conjugated systems. Although doubly fused pentagons represented by diketopyrrolopyrrole (DPP) have been used as an effective electron‐accepting unit, the relatively high‐lying frontier molecular orbital levels (FMOs) leave room for further improvement. We report herein the synthesis of a fluorinated dihydropentalene‐1,4‐dione (FPD) derivative as a strong electron‐accepting unit and the development of D−A−D π‐extended molecules. X‐ray analyses revealed that the presence of fluorine atoms contributed to the formation of high planar structures and slipped‐stacked packing. Electrochemical measurements indicated that the FPD derivatives showed relatively lower FMO energy levels than the corresponding DPP‐containing derivatives. The D−A−D molecule based on terthiophene and FPD showed semiconducting responses. This study demonstrates that the FPD unit can function as a new acceptor unit for organic semiconductors.
Investigation of silica nanoparticles grafted with sulphonated polymer for enhanced oil recovery at high temperature and high salt
Authors: Wenlong Qin , Guoqing Li , Lu Li , Hanxi Li , Ruixuan Li , Guowei Qin , Jiang Yang
Published: January 2023

Nano‐fluids' application for enhanced oil recovery (EOR) has attracted noticeable attention and formed a new research area in recent years. Currently, the greatest challenge in this area is to formulate stable nano‐fluids for oil reservoirs with high temperatures and salinity. To overcome the limitations of its application in high‐temperature drilling, polymer‐coated nanoparticles (SiO2‐PAMPS NPs) were prepared via solution polymerization of 2‐acrylamide‐2‐methyl‐1‐propane sulphonic acid (AMPS) from the surface of aminopropyl‐functionalized silica nanoparticles. The SiO2‐PAMPS NPs were characterized by Fourier‐transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and dynamic light scattering (DLS). The results indicated that the AMPS was successfully grafted onto the surface of silica nanoparticles, and the average diameter of SiO2‐PAMPS NPs was about 16 nm. The nano‐fluids showed noticeable stability in American Petroleum Institute (API) brine (2 wt.% CaCl2 and 8 wt.% NaCl) at 90°C beyond 46 days. When amphipathic nanoparticles were introduced to brine at 90°C, the potential of the nano‐fluids in recovering oil was evaluated by investigating the interfacial tension with kerosene oil and the oil contact angle in the nano‐fluids. The contact angle of the glass sheet surface before treatment was about 144°, while after SiO2‐PAMPS NPs treatment for 72 h, it became about 92°. Meanwhile, the nano‐fluids showed an excellent enhancing emulsibility property, which plays a vital role in promoting the development of EOR in high‐temperature and high‐salt environments.
Disulfide Crosslinking‐Induced Aggregation: Towards Solid‐State Fluorescent Carbon Dots with Vastly Different Emission Colors†
Authors: Fu Rui , Song Haoqiang , Liu Xingjiang , Zhang Yongqiang , Xiao Guanjun , Zou Bo , Waterhouse Geoffrey I. N. , Lu Siyu
Published: January 2023

Comprehensive Summary

Solid‐state fluorescent multi‐color carbon dots (SFM‐CDs), prepared using the same precursor(s) without the need for dispersion in a solid matrix, are highly demanded for a wide range of applications. Herein, we report a microwave‐assisted strategy for the preparation of SFM‐CDs with blue, yellow and red emissions within 5 min from the same precursors. The as‐prepared B‐CDs, Y‐CDs, and R‐CDs possessed bright fluorescence at 425 nm, 550 nm, and 640 nm, and photoluminescence quantum yields (PLQYs) of 54.68%, 17.93%, and 2.88%, respectively. The structure of SFM‐CDs consisted of 5‐oxo‐3,5‐dihydro‐2H‐thiazolo [3,2‐a] pyridine‐7‐carboxylic acid (TPCA) immobilized on the surface of a carbon core, with the size of the carbon core and degree of disulfide crosslinking between CDs both increasing on going from the B‐CDs to the R‐CDs, as verified by mechanochromic experiments. The excellent solid‐state fluorescence performance of the SFM‐CDs allowed their utilization as the fluorescent converter layer in multi‐color LEDs and white LEDs with a high color rendering index.
Total Synthesis of Starfish Cyclic Steroid Glycosides. Part 1, Synthesis of the Aglycone and Attempts at Installation of the Sugar Units
Authors: Shi Bingfeng , Chen Youxi , Geng Mingyu , Zhu Dapeng , Yu Biao
Published: January 2023

Comprehensive Summary

Sepositoside A (1) is the major and first cyclic steroid glycoside isolated from starfishes, which features a strained 16‐membered ring formed by tethering C3 and C6 of the steroid aglycone with a linear trisaccharide. We conceived a convergent synthetic plan in which sepositoside A was disconnected into a disaccharide and a steroid‐glucose hybrid ether. The desired 3β,6β‐dihydroxy‐Δ7,8‐23‐ one aglcyone was readily prepared from dehydroepiandrosterone in 12 steps. The etherification of the 6β‐hydroxy‐Δ7,8‐steroid with a variety of hexopyranoside‐C6‐electrophiles and CO2‐extrusion of a steroid‐pyranose hybrid carbonate were extensively studied; however, formation of the desired steroid‐pyranose etherate linkage has not been successful. Model studies on the β‐selective installation of the (1→2)‐linked disaccharide onto the steroidal C3β‐OH with the corresponding disaccharide α‐imidates were also examined, however, formation of the α‐glycosides prevailed. The present results force us to explore alternative approaches to construct the steroid‐pyranose etherate linkage and stepwise assembly of the glycans en route to the starfish cyclic steroid glycosides, which will be presented in two articles that follow.
Asymmetric Synthesis of Anti‐tuberculosis‐specific Drug TBAJ‐876 through Synergistic Li/Li Catalysis
Authors: Li Jing , Gao Feng , Ahmad Tanveer , Luo Yicong , Zhang Zhenfeng , Yuan Qianjia , Zhang Wanbin
Published: January 2023

Comprehensive Summary

TBAJ‐876, developed by TB Alliance, a novel anti‐tuberculosis‐specific drug, has entered Phase II clinical trials. Herein, the first asymmetric synthesis of TBAJ‐876 has been realized using synergistic Li/Li catalysis with excellent yield of 95% and 88 : 12 er (99.6 : 0.4 er, 10 : 1 dr after simple recrystallization). Furthermore, DFT calculations and 7Li‐NMR analysis illustrated the mechanism of the synergistic reaction: a chiral Li‐complex activates the nucleophile to control the stereoselectivity, while the other achiral Li‐complex activates the electrophile to catalyze the carbonyl addition reaction. Additionally, this protocol has been successfully carried out at 5 gram‐scale, showing its industrial potential.
Prof Norman Jaffe, DSc, MD (1933–2022): The Osteosarcoma Giant
Authors: Ottaviani Giulia
Published: January 2023

This brief note is written to laud the memory of Dr Norman Jaffe, DSc, MD, a professor of pediatrics, who was a pioneer in the treatment of osteosarcoma and other pediatric bone and soft tissue tumors.
Spending bill for 2023 includes major benefits for treatment of mental illness
Authors: Knopf Alison
Published: January 2023

At the end of 2022, Congress approved (and President Biden signed it, just in time to avert a government shutdown) a spending bill that includes measures to reauthorize vital mental health and substance use programs.
Confidentiality revamping proposed for substance use disorder treatment records
Authors: Knopf Alison
Published: January 2023

Late last year, the Department of Health and Humans Services (HHS) published a 260‐page Notice of Proposed Rulemaking (NPRM) on changes to 42 CFR Part 2, a regulation which protects the confidentiality of treatment records for alcohol and drug use disorders.
Managing for stakeholders towards corporate environmental sustainability
Authors: Góes Helna Almeida de Araujo , Fatima Ghulam , Santos Jhunior Ronaldo de Oliveira , Boaventura João Maurício Gama
Published: January 2023

The purpose of this paper is to clarify the relationship between the managing for stakeholders approach and corporate environmental sustainability. Focused on the debates on the impacts that organizations and their stakeholders have on society's welfare, our conceptual paper proposes a rationale addressing the question: In what ways does managing for stakeholders may influence corporate environmental sustainability? To this end, we analyze previous literature on managing stakeholders focused on how firms address stakeholders' environmental concerns and previous literature on corporate sustainability focused on managing stakeholders' expectations. There is a fit between adopting a managing for stakeholders approach and encouraging firms to become more environmentally sustainable. Furthermore, our rationale argues that this approach may also influence firms to build closer relationships with stakeholders by adopting transparent practices and proactive environmental strategies, impacting synergic value creation, stakeholder engagement, and overall performance. Finally, we argue for a novel approach to link managing for stakeholders and corporate sustainability while suggesting propositions for future investigation and implications for practitioners.
Small molecule Z363 co‐regulates TAF10 and MYC via the E3 ligase TRIP12 to suppress tumour growth
Authors: Xiong Yan , Wang Lulu , Xu Shiyao , Fu Beibei , Che Yuchen , Zaky Mohamed Y. , Tian Rong , Yao Rui , Guo Dong , Sha Zhou , Lin Feng , Lin Xiaoyuan , Wu Haibo
Published: January 2023

Background

The MYC oncoprotein, also known as the master regulator of genes, is a transcription factor that regulates numerous physiological processes, including cell cycle control, apoptosis, protein synthesis and cell adhesion, among others. MYC is overexpressed in approximately 70% of human cancers. Given its pervasive role in cancer biology, MYC down‐regulation has become an attractive cancer treatment strategy.

Methods

The CRISPR/Cas9 method was used to produce KO cell models. Western blot was used to analyzed the expressions of MYC and TATA‐binding proteinassociated factors 10 (TAF10) in cancer cells (MCF7, A549, HepG2 cells) Cell culture studies were performed to determine the mechanisms by which small molecules (Z363119456, Z363) affects MYC and TAF10 expressions and functions. Mouse studies were carried out to investigate the impact of Z363 regulation on tumor growth.

Results

Z363 activate Thyroid hormone Receptor‐interacting Protein 12 (TRIP12), which phosphorylates MYC at Thr58, resulting in MYC ubiquitination and degradation and thereby regulating MYC target genes. Importantly, TRIP12 also induces TAF10 degradation, which reduces MYC protein levels. TRIP12, an E3 ligase, controls MYC levels both directly and indirectly by inhibiting MYC or TAF10 activity.

Conclusions

In summary,these results demonstrate the anti‐cancer properties of Z363, a small molecule that is co‐regulated by TAF10 and MYC.
XBP1‐elicited environment by chemotherapy potentiates repopulation of tongue cancer cells by enhancing miR‐22/lncRNA/KAT6B‐dependent NF‐κB signalling
Authors: Jia Xiaoting , Wang Ge , Wu Lihong , Pan Hao , Ling Li , Zhang Jianlei , Wen Qingquan , Cui Jie , He Zhimin , Qi Bin , Zhang Shuxu , Luo Liyun , Zheng Guopei
Published: January 2023

Background

Tumour repopulation initiated by residual tumour cells in response to cytotoxic therapy has been described clinically and biologically, but the mechanisms are unclear. Here, we aimed to investigate the mechanisms for the tumour‐promoting effect in dying cells and for tumour repopulation in surviving tongue cancer cells.

Methods

Tumour repopulation in vitro and in vivo was represented by luciferase activities. The differentially expressed cytokines in the conditioned medium (CM) were identified using a cytokine array. Gain or loss of function was investigated using inhibitors, neutralising antibodies, shRNAs and ectopic overexpression strategies.

Results

We found that dying tumour cells undergoing cytotoxic therapy increase the growth of living tongue cancer cells in vitro and in vivo. Dying tumour cells create amphiregulin (AREG)‐ and basic fibroblast growth factor (bFGF)‐based extracellular environments via cytotoxic treatment‐induced endoplasmic reticulum stress. This environment stimulates growth by activating lysine acetyltransferase 6B (KAT6B)‐dependent nuclear factor‐kappa B (NF‐κB) signalling in living tumour cells. As direct targets of NF‐κB, miR‐22 targets KAT6B to repress its expression, but long noncoding RNAs (lncRNAs) (XLOC_003973 and XLOC_010383) counter the effect of miR‐22 to enhance KAT6B expression. Moreover, we detected increased AREG and bFGF protein levels in the blood of tongue cancer patients with X‐box binding protein‐1 (XBP1) activation in tumours under cytotoxic therapy and found that XBP1 activation is associated with poor prognosis of patients. We also detected activation of miR‐22/lncRNA/KAT6B/NF‐κB signalling in recurrent cancers compared to paired primary tongue cancers.

Conclusions

We identified the molecular mechanisms of cell death‐induced tumour repopulation in tongue cancer. Such insights provide new avenues to identify predictive biomarkers and effective strategies to address cancer progression.
The relationship between individual symptom connectivity and global eating disorder symptom severity
Authors: DuBois Russell H. , Rodgers Rachel F. , Fuller‐Tyszkiewicz Matthew , Shiyko Mariya , Franko Debra L.
Published: January 2023

Background

The network approach has emerged as a useful framework for conceptualizing and investigating psychopathology, including eating disorders. Network connectivity, that is, the density of the connections among network nodes, has been somewhat neglected despite its theoretical relevance. As predicted by network theory, symptom connectivity would be distinct but related to symptom severity and may be a useful clinical indicator of psychopathology as stronger and/or more diffuse connections among symptoms offer more avenues for symptom activation. This study aimed to investigate the relationship between moment‐by‐moment individual‐level symptom connectivity and global levels of symptom severity in the context of eating disorder symptoms and experiences.

Methods

A sample of 58 female undergraduate college students, mean (SD) age = 20.5 (3.1) provided data on eating disorder symptoms eight times a day over the course of 10 days. Network analyses were used to calculate the eating disorder symptoms network connectivity for each participant. In addition, participants completed survey of self‐report measures of eating disorder symptom severity and trait mindfulness and body image flexibility.

Results

Analyses revealed a moderate, positive relationship between individual network connectivity and eating disorder symptom severity. In addition, symptom connectivity predicted unique variance of symptom severity even after controlling for other clinically‐relevant variables.

Conclusions

Individual‐level network connectivity may be an important dimension of psychopathology and further work exploring the role of network connectivity is warranted.

Public Significance

These findings suggest that symptom severity and the extent to which different eating disorder symptoms are connected are related but different dimensions. Investigating how these different dimensions play a role in eating disorder pathology could help to better understand and treat these disorders.
A portable wireless‐sensor system from all‐in‐one sensor array based hybrid solid contact layer for point‐of‐care ion monitoring in river basin
Authors: Qileng Aori , Peng Haihua , Yin Tongyue , Lin Xubin , Zhai Bingqian , Chong Yunxiao , Li Kangshun , Liu Yingju
Published: January 2023

The sensor arrays are considered as a promising way to aim at point‐of‐care (POC) testing for the detection of different ions in environment through the use of solid‐contact ion‐selective electrodes (SC‐ISEs). However, the exorbitant equipment and intricate process for the production of SC‐ISEs arrays has limit its application. Herein, the Au with nano‐branched structure (Au NBS) and poly (3,4‐ethylenedioxythiophene): poly (styrenesulfonate) (PEDOT : PSS) were decorated on the surface of bare pad of traditional printed circuit boards coated with Au (Au‐PCB) to construct a hybrid solid‐contact layer including double‐layer capacitance and pseudocapacitance of SC‐ISEs synergistically, thus the multichannel SC‐ISEs exhibited high stability and specificity. Overall, based on portable multichannel sensor and homemade APP (Ion Analysis), a wireless all‐in‐one sensor system was constructed to detect ions with the limit of NO3−, Cl−, Na+, K+, Ca2+ and Mg2+ as 0.047 mM, 0.039 mM, 0.022 mM, 0.066 mM, 0.045 mM and 0.024 mM, respectively. Besides, it can detect such ions in river basin successfully. With the cost of each electrode less than 0.5 $, this sensor arrays enable a wide range of hazardous ion monitoring in water environment.
First‐Principles Investigations to Evaluate NiCl2/NiF2 as Cycle‐Catalyzed Electrolyte Additives to Improve Li–S Batteries’ Performance
Authors: Wang Bingqian , Lu Shuhan , Zhang Panyu , Jiang Xiaoli , Zhao Xinxin , Wang LiLi , Yin ZhiXiang , Wu Jianbao
Published: January 2023

The potential application of two electrolyte additives, NiCl2‐DME and NiF2‐DME, in lithium–sulfur batteries is investigated by density functional theory calculations. The results show that both electrolyte additives can effectively adsorb soluble lithium polysulfide (LiPSs) in the electrolyte. With the progress of the charging–discharge reaction, NiCl2 and NiF2 separate from Li2Sn when it is converted to S8 and recombine with 1,2‐dimethoxy‐ethane (DME) to achieve the purpose of cyclic adsorption of polysulfide in the electrolyte. At the same time, NiF2 and NiCl2 also have a catalytic effect in the cycling process. When adsorbed with Li2Sn, the bond length of the Li–S bond in Li2Sn is elongated, which causes the reduction of the Li2Sn activation energy, making it easier to be oxidized, and accelerating the conversion speed of Li2Sn and reducing Li2S, Li2S2 deposition on the surface of the electrode. Therefore, NiCl2‐DME and NiF2‐DME are ideal dual‐function electrolyte additives.