bluuebunny/crossref_metadata_2025 huggingface dataset:
ASSESSMENT OF SHEAR BOND STRENGTH OF RESTORATIVE MATERIALS IN VARIOUS DEPTH OF HARD DENTAL TISSUE PREPARATION IN FRONT TEETH
Authors: Vodorez Ya.Yu. , Tkachenko I.M.
Published: July 2019

In modern dentistry, there are two different approaches to the restoration of anatomy and aesthetics of anterior teeth. The most common is the option of direct restoration with using composite resin materials. The second option is the restoration with using ceramic materials that is carried out through the cooperation of the dentists and the dental laboratory technicians, or, alternatively, with various CAD-CAM systems directly at the dental office. This experiment was carried out by using teeth (premolars, incisors) without significant loss of hard dental tissues. Teeth with abrasion (all except 1st degree) were excluded from the test group. Within the framework of the planned study, the selected extracted teeth were prepared (a certain volume of hard tissues was removed from the vestibular side (a subgroup of the teeth prepared within in the enamel layer, and a subgroup of teeth with the exposed dentine). A total of 40 teeth were prepared (20 teeth with the exposed dentine, 20 with the enamel preparation). The tests were carried out by using a universal testing machine AUTOGRAPH AGS-J. A sample with a tooth was placed at the top of the device then the second part of the sample containing the plate of the material (composite or ceramic), was covered with the second part of the device to be tested, and neatly, trying to avoid applying tension to the adhesive butt joints, and then fastened to the lower clamping device of the tension testing machine. We created the shear forces before the sample was destroyed, paying attention to the character of adhesion line oddments. The results of the experiment have demonstrated that the most optimal shear strength is found out in the complex of hard tooth tissues and ceramic materials IPS Empress Aesthetic and EX3, in the teeth prepared within the tooth enamel layer. When using composite resin, the values studied are lower by 11,4% and 18,1%, (application of adhesion systems of 5th and 7th generations, respectively). In the cases when dentin is exposed, the shear strength decreases by 19,5% when using ceramics modified by leucite glass, by 17,3% in the case of application of feldspar ceramics, and by 8,4% and 13,2% for composite resin restoration when using adhesive systems of 5th and 7Ith generations respectively.
THE RELATIONSHIP BETWEEN CALPROTECTIN AND PARAMETERS OF LIPID AND CARBOHYDRATE METABOLISM, ANTHROPOMETRIC AND INFLAMMATORY PARAMETERS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND DIABETES MELLITUS TYPE 2
Authors: Zhuravlova M. I.
Published: July 2019

Nowadays, an acute myocardial infarction is one of the leading causes of mortality among the population. The EHS-DH registry data clearly illustrate the association between the comorbidities and high mortality following acute myocardial infarction during a year period of follow up. The pronounced influence of carbohydrate metabolism disturbances on the survival of such patients has already been reported. The aim of the study was to analyze the immune inflammation relationships based on assessing calprotectin and the parameters of lipid and carbohydrate metabolism, to evaluate the presence and nature of the relationship between these parameters and carbohydrate metabolism parameters based on the study of blood glucose, insulin and insulin resistance (by the indices HOMA, QUICKI, Caro), anthropometric indicators and inflammatory indicators (monocyte and neutrophile levels). Materials and methods. The study included 64 patients (mean age 65, 31 ± 1.62 years) with acute myocardial infarction and concomitant diabetes mellitus type 2. The design of the study included the primary laboratory investigation of patients during the first day since the onset of acute myocardial infarction with the elevation of the ST segment before the initiation of thrombolytic therapy or percutaneous intervention. The direct correlation between the calprotectin concentration and the HOMA insulin resistance index (R = 0.52; p <0.05), insulinemia (R = 0.57; p <0.05), fasting glycaemia (R = 0, 59; p <0.05), as well as inverse correlation relationships between the Caro index (R = 0.68; p <0.05) and the QUICKI index (R = 0.59; p <0.05) were found out. Moreover, a direct correlation between calprotectin and triglyceride levels (R = 0.31; p <0.05), and negative correlation with high density lipoprotein (R = 0.35; p <0.05) was established as well. The level of total cholesterol and low density lipoproteins showed no significant association with the proinflammatory factor (R = 0.12; p> 0.05 and R = 0.18; p> 0.05, respectively). Conclusions. The increase in the body mass index and the activity of serum monocytes and neutrophils is associated with high concentrations of calprotectin that is accompanied by disturbances of carbohydrate homeostasis towards the growth of insulin resistance and changes of lipidograms of proatherrogenic nature.
PREDICTING THE DEVELOPMENT OF MAXILLOFACIAL ANOMALIES IN YOUNG SCHOOL-AGE CHILDREN
Authors: Melnyk V.S. , Horzov L.F.
Published: July 2019

Recent studied have pointed out an increase in the prevalence of maxillofacial anomalies, and the rates of their occurrence rate in children of different regions of Ukraine is an evidence of the polyetiologic nature of this pathology. The formation and development of the human body is predetermined by a number of factors including parental genetic characteristcs, the state of mother's health, and the course of pregnancy that, in turn, is amenable to the influence of some external factors, e.g. social, hygienic, environmental and others. The purpose of the work was to develop an algorithm and a technique for predicting the development of maxillofacial anomalies in young school-age children. The study of the health status of children with maxillofacial anomalies included a retrospective analysis of conditions during perinatal development by reviewing data from obstetric and perinatal records (74 children). The control group consisted of 67 children who had no maxillofacial anomalies. Social, hygienic, environmental, medical and biological factors were investigated in the families having the children with and without maxillodental anomalies. On the basis of the data collected, a matrix for predicting the development of maxillofacial anomalies in young school-age children was compiled. The retrospective analysis of 74 children has shown that the risks we predicted are confirmed in 92.4% of cases. The remaining 7.6% can be explained by the combination of various adverse factors in the postnatal period, such as bad habits, modes of baby's nutrition, etc. The results obtained have demonstrated the highest values ​​of relative risks are due to the factors known as leading in the development of maxillodantal anomalies: heredity (34.6 and 34.3), large foetus (35.3). Applying this prediction algorithm to each newborn makes it possible to evaluate the risks of maxillodental anomalies and to carry out preventive and corrective measures in early period to prevent the onset and development of maxillofacial anomalies.
EVALUATION OF TOPICAL APPLICATION OF BACTERIOPHAGES IN THE TREATMENT OF ERYSIPELAS
Authors: Ivashchenko D.M. , Dudchenko M.O. , Kravtsiv M.I. , Prikhidko R.A.
Published: July 2019

Erysipelas is known as a human infectious disease, which, unfortunately, in recent years has not reduced its incidence rate in spite of all the advances of medicine. There is a tendency to an increase in the incidence of complicated forms of erysipelas, the consequences of which require prolonged conservative treatment and expenses. Moreover, there is a transition to recurrent forms often associated with large-scale surgical interventions and sometimes plastic surgeries to close skin defects. Thus, the search for best options for treating erysipelas, preventing its recurrence or transition to more severe clinical forms is an urgent issue that requires research aimed at improving the integrated treatment of this pathology. One of the solutions to this problem is the use of bacteriophages in combination with the standard treatment of erysipelas. The aim of the study was to improve the clinical results of erysipelas complex treatment by adding local bacteriophage therapy. Our clinical study included 28 patients with erythematous and erythematous-bullous forms of erysipelas. Two groups of patients were made up to compare the efficacy of the combined use of bacteriophages and standard antibacterial therapy. Evaluation of the efficacy was performed by clinical and microbiological methods. Based on the results of clinical study, we have found out that topical use of bacteriophages incorporated into dressing material in the course of erysipelas treatment, in addition to standard antibacterial therapy and detoxification leads to a statistically significant decrease in the duration of hyperthermic reactions in patients by 0.6 ± 0.13 days, lowering in intensity and the duration of pain syndrome by 0.9 ± 0.21 days, a more rapid local swelling fading by 0.5 ± 0.3 days, enhanced decrease in local skin hyperemia by 27% and accelerated microbial decontamination in the lesion areas by 21%. The results obtained allow us to recommend applying local bacteriophage treatment as a part of the standard management of erysipelas to promote the healing period and to improve the clinical condition of patients.
MEDICAL BLOG IN GENRISTIC DIMENTION
Authors: Levchenko K.I.
Published: July 2019

Nowadays there is growing popularity of medical blogs as new communicative environment and one of the promising areas of linguistic knowledge. However, in Ukrainian linguistic studies, there are few works devoted to exploring their genre characteristics that predetermines the relevance of this research. The purpose of the work is to analyze the medical blog as a genre of Internet communication. To achieve this aim, we designed and fulfilled the following objectives: to clarify the criteria for identifying a medical blog as an independent genre and to describe its genre characteristics. The methodology of this research included general scientific and linguistic methods and techniques: a descriptive method, observation techniques, comparisons and generalizations, discourse analysis, conversational analysis. The genre characteristics of medical blogs have been analyzed based on T.V. Shmeleva’s genre model. The communicative purpose, the author’s role and representation as a test addressor and the characteristics of potential addressee, the image of the past, the image of the future, and the type of dictum context and the linguistic tools for their implementation into the texts. The communicative goal of a medical blog is to convey the professional opinion of a specialist to readers, highlight issues that most often arise in medical practice, and disseminate medical and scientific knowledge among Internet users that is typical of information genres. Medical blogs also promote a healthy lifestyle and illustrate the nuances of medical procedures to help readers choose the right strategy for keeping fit and healthy. This type of communicative behaviour implements the informative and imperative goals of blogging. The author is presented from the standpoint of education, professionalism, responsibility, unselfishness and morality. Another distinctive feature is no phenomena of author’s anonymity, “virtual” and speech masks inherent in the diary blogs. The medical blog provides an unlimited number of recipients: fellow doctors and patients. This is an initial genre, providing for the extension of the communication of the addressor-addressee in the future. Dictum context of a medical blog is focused on reality, with a clear scientific position and rationality. The authors mainly use standard speech patterns within this type of genre.
APPLYING CORPUS APPROACH AT THE ENGLISH CLASSES IN HIGHER EDUCATIONAL ESTABLISHMENTS
Authors: Pryima L.Yu. , Chupryna K.S.
Published: July 2019

The article describes the possible ways of applying the achievements of corpus linguistics in the ESL classroom at the HEIs. The notion of a language corpus was defined, a journey into the history of the first corpus creation was taken, and the most popular modern English-language corpora (British National Corpus, The Oxford English Corpus, COCA, etc.) were considered. The efficiency of applying the corpus method in teaching a foreign language in higher education has been proven. Thus, the use of corpora in students' work along with the inductive method contributes to their understanding of the basic linguistic patterns and the development of linguistic intuition, the material of the study being exclusively authentic texts. The possibility of using direct and indirect corpus approach to assist the formation of students' lexical, grammatical, stylistic and phonetic skills has also been studied. The direct applying this method may include teaching corpus linguistics to university students as a purely academic subject, performing certain tasks or exercises using concordance programs and performing individual research projects by students. And the indirect corpus approach can include publishing links, developing materials and language testing. The article provides information on special software that enables one to carry out corpus training and analyzes the main types of tasks that can be created using these programs. Finally, the article discusses the reasons for the unpopularity of the corpus method in the Ukrainian HEIs at the present stage of education and justifies the appropriateness of its wider use in the future academic environment.
SCIENTIFIC APPROACHES TO STRUCTURING THE CONTENT OF EDUCATIONAL MATERIAL OF MEDICAL DISCIPLINE
Authors: Tovstiak M. M. , Holovanova I. A.
Published: July 2019

The National Strategy for the Development of Education in Ukraine up to 2021 has been updated as the most significant goals for the next decade in order to increase the availability of high quality, competitive education for the citizens of our country in accordance with the requirements of innovative sustainable development of the society, economy, ensuring the personal development of people according to their individual desires, abilities, and needs on the basis of life-long learning. All the above requires, first of all, the provision of the national education system by highly skilled personnel, trained in accordance with the most progressive national and world trends. It is precisely professionalism that is viewed as the main causal condition for the successful functioning of the medical industry at all its levels. The issues on structuring the content of the educational material that ensures the effectiveness of its didactic presentation and, as a consequence, increases the level of learning effectiveness, are considered by didactics at all educational levels and have a long history. Modern approaches to their solution, related primarily to the specifics of the current period, identified by professionals as an information approach due to the huge streams of affordable personal information and the ever-increasing opportunities for its transfer, are presented in numerous reports. However, the analysis of the practice of educational activities in the educational sector, scientific research in the field of medical training and professional activities point out the existence of a number of interrelated contradictions that complicate the development and further improvement of the professional competence of medical specialists. Relevance of the outlined problem, its inadequate exploring, and necessity to identify and address shortcomings have led to the choice of the theme of the research "Scientific approaches to the structuring of the content of educational material of medical disciplines."
THERAPY AND PREVENTION FOR ACUTE AND CHRONIC LYMPHADENITALS OF MAXILLOFACIL AREA IN CHILDREN
Authors: Tkachenko P.I. , Dobroskok V.O. , Dolenko O.B. , Korotych N.M. , Popelo Yu.V.
Published: July 2019

The article presents the reviews of the relevant literature on the effectiveness of therapeutic and preventive measures in children with acute and chronic lymphadenitis of non-odontogenic and odontogenic origin of the maxillofacial localization. Despite the large number of technical innovations and modern pharmacological preparations, it is not always possible to achieve the desired success. Moreover, a number of factors as the peculiarities of the perinatal and posntatal development of the child, the role of the concomitant somatic pathologies, the premorbid background, the versatility of the etiological factors and the pathogenetic changes sometimes are far from being taken into account. Special attention should be paid to the further improvement of ways towards advancing antibacterial therapy of purulent foci that should be based on the techniques elaborated for administering reduced doses of the drug and can be achieved by para- and endolymphatic application of antibacterial drugs. However, the introduction of this method in clinical dentist practice requires the objectivity of the assessment of its therapeutic efficacy, as the results of the study of pharmacokinetics have shown that such mode of administering a daily dose of antibiotics provides the inhibitory concentrations of the drug for many infectious agents within 24-48 hours. Immunotherapy in the treatment of purulent surgical diseases is an essential component of the integrated treatment, and the correction should be based on the clear evidence of the deficiency of individual components in the immune defence. The investigation of the pharmacological action of antioxidants has demonstrated their marked anti-peroxide and antiphospholipase effects, however, some issues regarding their influence on the state of the oral cavity with these types of the disease are remaining unclear. Many years of the experience in applying physiotherapeutic agents for purulent wounds have been proven as effective and promising. It is necessary to emphasize that the drugs used in the first phase of the wound process possessed not only antibacterial effects, but also a significant osmotic activity and necrolytic properties. In the phase of scar remodelling and epithelisation, ointments stimulating reparative processes and promoting epithelisation are recommended to apply. Unfortunately, there are few scientific studies on the effect of therapy and prevention on acute and chronic inflammatory processes of the maxillofacial area in children. At present, this issue is in the focus of researchers’ close attention that is implemented through the elaboration of new approaches taking into account the predominant role of the main mechanisms of pathogenesis.
GENERAL BIOLOGICAL PATTERNS OF THE STRUCTURE OF HUMAN MAJOR AND MINOR LACRIMAL GLANDS AND UNDER-RESEARCHED ASPECTS OF THEIR MORPHOLOGY
Authors: Katsenko A. L. , Sherstiuk O.A. , Svintsytska N.L. , Piliuhin A.V. , Piliuhin V.A.
Published: July 2019

The article discusses the fundamental and modern data on the structure and functions of human large and small lacrimal glands. The palpebral lobe of the human lacrimal gland consists of numerous fairly large lobules, which are almost of identical structure. Each lobule has several axial excretory intralobular ducts. Their branches along the whole length are surrounded by secretory epithelial components in the form of terminal sections and the corresponding finniest terminal lacrimal ducts that are grouped into the grape-bunch structural elements. Blood supply to the capillary network of the lacrimal gland and its alveoli is carried out by several arterioles that run through very large interstitial spaces rich in fatty tissue. Each arteriole supplies several adjacent lobules. The network of capillaries can be described as integral and is not divided into segments that would correspond to sublobular units. Blood capillaries are located in the spaces between several adjacent terminal portions. Thus, the fact of close syntopic similarity of the intralobular excretory ducts and postcapillary venules has been confirmed. The article poses the appropriateness of more detailed morphological studying of anatomical and topographic characteristics of the lacrimal glands. If has been found out the lack of information on the cellular composition of the wall of the excretory ducts of the lacrimal gland, both in humans and in laboratory rats, in order to compare their morphology and the quality of the secretion they produce. It would be interesting to compare the morphology of the human lacrimal glands and the garder gland in rats to identify general biological characteristics of the structure and functioning.
CLASSICAL AND MODERN TELESCOPIC CONNECTION SYSTEMS
Authors: Tarashevskaya Yu. E.
Published: July 2019

The purpose of this work is to identify, evaluate and compare the scientific views on the role of telescopic crowns in fixing partial removable dentures. Materials and methods. Analytical study of relevant scientific sources on the issue of the restoration of dentition defects with dentures retained by telescopic crowns. To replace defects in dentition, partial removable dentures are the best option due to their optimal ratio between such parameters as aesthetics, quality and price. The analysis of the relevant literature has demonstrated that using telescopic attachment is the best choice for restoring chewing efficacy, functioning and aesthetics of the maxillofacial system, for removing the deformities of the occlusive surface of the dentition and traumatic occlusion in patients with partial loss of teeth. All of the above mention demonstrates that telescopic dentures have many advantages supported by observing the dynamics of follow up period in individuals who underwent the correction with partial removable dentures and by the opinions of experts. Having analyzed numerous reports of national and international researchers, we can conclude that the advantages of retaining removable dentures by telescopic systems are determined by a number of their capabilities that include the distribution of chewing pressure on the abutment teeth in accordance with their longitudinal axes, providing positive effect on the periodontium and reducing the atrophy of the tissues of the prosthetic bed compared with other retaining systems, as well as by providing a "perfect" aesthetic appearance of the dental appliance.
KIDNEY DAMAGE IN PATIENTS WITH RHEUMATOID ARTHRITIS
Authors: Tkachenko L.A. , Kostrikova U.A. , Yarmola T.I. , Pustovoit G.L. , Talash V.V.
Published: July 2019

The purpose of this work is to perform a general analysis of relevant literature on the issue of kidney damage in patients with rheumatoid arthritis. Kidney damage in patients with rheumatic diseases is potentially dangerous, as it can lead to the development of terminal renal failure that may require replacement renal therapy. Amyloidosis often leads to kidney failure in patients with rheumatoid arthritis. Renal amyloidosis more often develops in patients with acute course of rheumatoid arthritis and under maximal immunological disorders. In patients with renal amyloidosis against the background of rheumatoid arthritis, manifestations of joint affection decrease, while the renal-uremic syndrome takes a predominant role. Signs of nephrotic syndrome and chronic renal failure develop gradually. Kidney damage can be caused by medications for rheumatoid arthritis. The choice of the optimal scheme of individual-centred therapy is vitally important for patients, since every aggravation of both rheumatic disease and secondary renal damage leads to the progression of chronic renal failure.
IMPACT OF RESTRICTIVE REGIMEN OF INFUSION THERAPY ON THE PERIOPERATIVE PERIOD IN PATIENTS WITH URGENT ABDOMINAL PATHOLOGY
Authors: Kravets O.V.
Published: July 2019

One of the leading pathogenetic processes that is specific for emergency abdominal pathology is hypovolemia. The primary method of its treatment is infusion therapy. The purpose of the study is to evaluate the effectiveness of the restrictive regimen of infusion therapy in patients with emergency abdominal pathology.

Materials and methods. We examined 50 patients who were performed on emergency laparotomy. Perioperative infusion therapy in all patients was carried out in a restrictive regimen with balanced crystalloid solutions. We studied the indicators of water metabolism: daily and cumulative water balances, the percentage of fluid excess. We determined water sectors of the body by the method of non-invasive bioelectric rheography. Results. The study has found out the presence of the initial depletion of the extracellular fluid volume due to a decrease in both interstitial and intravascular volumes in patients with urgent abdominal pathology. Intravascular deficiency was due to a decrease in plasma volume. Replenishment of extracellular deficiency by restrictive regimen of infusion therapy restored the plasma volume to normal values since one day after surgery; interstitial volume started restoring on the 7th days of observation, compared to the normal intracellular volume on the 3 days of the postoperative period. Conclusions: restrictive infusion therapy regimen enables to completely and safely restore extracellular volume depletion on the 7 days of the preoperative period by correcting plasma deficiency since the 1 day of the post-operative period; to replenish interstitial volume on the 7 days and to prevent the development of oedema during “zero” daily water balance, as well as to slightly increase the cumulative water balance and the percentage of excess fluid.
MANIFESTATION OF THE AFFECTIVE SPECTRUM DISORDERS IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION DEPENDING ON THE TREATMENT TACTICS
Authors: Kudria I.P. , Shevchenko T.I. , Nasonov D.I. , Sorokina S.I. , Shaposhnik O. A.
Published: July 2019

Today, cardiovascular disease and anxiety-depressive disorders are the most serious and urgent medical and social problem around the world. The purpose of this study was to determine the severity of anxiety-depressive disorders in patients with acute myocardial infarction, depending on the treatment tactics as a precondition for the drug therapy correction. We studied 73 patients with the above-mentioned pathology, who were divided into two groups: I group included 44 patients who underwent percutaneous coronary intervention, in particular, urgent coronary angiography with subsequent stenting of the infarction-related coronary artery; the II group included 29 patients, who did not undergo urgent coronary angiography. The examination of patients was conducted in accordance with Ukrainian standards, using the patients’ questionnaire on their health status, the hospital scale of anxiety and depression. Mild ("subclinical") depression was diagnosed according to the patient's questionnaire in 81,9% of patients with acute myocardial infarction who underwent the stenting of the infarction-related artery; while 86.2% of the patients without surgical intervention who received only pharmaceutical therapy were diagnosed to have mild (“subclinical") and severe forms of depression. According to the hospital scale of anxiety and depression, 36,4% of the patients with acute myocardial infarction after percutaneous coronary intervention were diagnosed to have depression and the 34,1 % of the patients were found to have anxiety. 62,1% of the patients with acute myocardial infarction, who had not been urgently performed on coronary angiography, demonstrated depression, while 72,4% of the patients were assessed as anxious. For the patients with acute myocardial infarction, who underwent myocardial revascularization with stenting of the infarction-related artery, predominance of subclinical anxiety and depression manifestation is characteristic unlike the patients received the medication only; recurrence has been found as typical for clinically expressed anxiety and depression. The presence of anxiety-depressive disorders of varying severity requires a psychotherapeutic correction of the psycho-emotional sphere in patients with serious cardiovascular diseases.
THE EFFECT OF ANTIOXIDANT THERAPY ON THE SEVERITY OF THE COURSE, THERAPY EFFICACY AND DURATION OF REMISSION IN PATIENTS WITH PSORIASIS
Authors: Bezeha O. , Popova I.
Published: July 2019

The prevalence of psoriasis has accentuated the high relevance of searching new approaches towards its treatments. This article describes the connection between the development of the clinical picture and lipid peroxidation, and studies the expediency of using drugs with antioxidant properties as a component of the treatment. The products of lipid peroxidation regulate cell proliferation and permeability of cell membranes, thus the function and structure of the skin is directly dependent on the level of lipids and phospholipids. Patients with either mild or severe psoriasis have been found out to demonstrate some changes in the blood serum: increased cholesterol, triglycerides and free fatty acids, as well as a change in the ratio of the fractional content of phospholipids in erythrocyte membranes. Taking into account the above mentioned factors of psoriasis, we can suggest that it would be reasonable to include antioxidants into the integrated therapy. Antioxidants are the group of biologically active substances that possess an ability to interact with various reactogenic oxidants, reactive oxygen species and other free radicals that leads to their full or partial inactivation. During this study resveratrol was added to standard psoriasis therapy. The scope of laboratory research included: diagnosis of changes in the blood biochemical analysis taken on an empty stomach in the morning to investigate the content of total protein, albumin, bilirubin, low and high density lipids, phospholipids, cholesterol, alanine aminotransferase, aspartate aminotransferase. It has been found out the reduction of symptom in the patients who received complex therapy modified with resveratrol was more marked than in patients who received standard therapy only. A more intensive decrease in infiltration, erythema, desquamation, and itching has been clinically observed as well.
MYELOTOXICITY ASSESSMENT DURING INDUCTION CHEMOTHERAPY IN PATIENTS WITH ACUTE MYELOID LEUKEMIA
Authors: Lymanets T.V.
Published: July 2019

Hematologic toxicity of cytostatic drugs is one of the main complications caused by induction chemotherapy for acute myeloid leukemia and ranks first position among the causes of mortality in patients at this stage of treatment. The aim of this study is to investigate the nature and occurrence rate of myelotoxicity in patients with acute myeloid leukemia during the standard induction chemotherapy. Materials and methods. The study involved 39 inpatients (23 (59%) women and 16 (41%) men, the average age of patients was 58.5±7.69) with newly diagnosed acute myeloid leukemia who took the course of treatment at hematology department of the M.V. Sklifosovsky Poltava Regional Clinical Hospital. All patients received standard courses of induction chemotherapy "7+3" or "5+2". The patients had complete blood count prior to the start of chemotherapy, on the 7th, 14th and 28th days of the first induction course. The myelotoxicity grade was assessed using the Common Terminology Criteria for Adverse Events (CTCAE) version 4.02. Results. Myelotoxicity of chemotherapy in the treatment of acute myeloid leukemia reached the 4th highest toxicity grade on the 14th day of the first induction course and manifested by neutropenia in 22 (56.4%) patients with the development of febrile neutropenia; thrombocytopenia was detected in 11 (28.2%) with severe skin hemorrhagic syndrome and anemia was detected in 7 (17.9%) patients. Conclusions. Standard induction chemotherapy of acute myeloid leukemia has a high toxicity grade, requires regular careful monitoring of hematological parameters and supportive therapy; due to its toxicity, standard induction chemotherapy often leads to the next treatment course delay.
THE EFFECT OF PRO197LEU POLYMORPHISM OF THE GPX1 GENE ON THE DEVELOPMENT OF COMPLICATIONS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND PATIENTS WITH TYPE 2 DIABETES MELLITUS AND COMORBID OBESITY
Authors: Popruha A.
Published: July 2019

Type 2 diabetes and obesity are among the most common diseases worldwide. Due to the extremely high prevalence of these diseases that has been reached in recent years, at present they are recognized as non-infectious epidemics. Obesity is the leading modifying pathogenetic factor of type 2 diabetes. Almost 90% of diabetic patients are overweight or obese. Today, adipose tissue is positioned as an endocrine organ that produces numerous proteins with autocrine, paracrine, and endocrine functions. As a result, chronic activation of the body's immune system occurs with overproduction of a wide range of pro-inflammatory cytokines with subsequent development and progression of chronic non-specific systemic inflammation and oxidative stress, which make a significant contribution to the development of many chronic diseases. Based on the relationship of the pathogenetic moments between type 2 diabetes and obesity, attention should be paid to study the role of genetic factors of the antioxidant defence system, and, in particular, the glutathione peroxidase-1 (GPx1) gene polymorphism, on the development and course of these pathologies. Therefore, we investigated the specific effects of the Pro197Leu polymorphism of the GPx1 gene on the development of diabetic and cardiovascular complications in patients with type 2 diabetes and patients with type 2 diabetes and comorbid obesity in the Poltava region. Significant relationship was found out between the presence of the Leu allele and the increased risk of both type 2 diabetes and type 2 diabetes in combination with obesity. It has been established that in the patients with type 2 diabetes and patients with type 2 diabetes and comorbid obesity, the carriage of the Pro allele can be a protective factor with a protective effect towards preventing the development of complications in the clinical and pathogenetic course of both diseases, while the presence of the mutant Leu allele in the homo- and heterozygous state of the GPx1 gene is associated with an increased risk of the development of the diseases studied as well as concomitant diabetic and cardiovascular complications with more adverse clinical course of both diseases.
EFFICACY OF THE REHABILITATION PLAN BASED ON THE THEORY OF MUSCULAR SPIRALS IN PATIENTS WITH SCAPULOHUMERAL PAIN SYNDROME ACCORDING TO SHEAR WAVE ELASTOGRAPHY DATA
Authors: Strashko E.Yu. , Ivanitsky I.V. , Ivanitskaya T.A.
Published: July 2019

The scapulohumeral pain syndrome (frozen shoulder) is an umbrella term for various pathological conditions characterized by pain and limited range of motion in the shoulder joint that considerably reduces a person’s ability to work and impairs the quality of life. The most common etiological factors are: load on the muscles of the shoulder girdle, traumatic injuries of the shoulder joint in patient’s history and overstretching and partial tearing of the ligaments of the shoulder joint, vertebral radiculopathy with the development of reflex and dystrophic disorders in the corresponding muscles, ligaments and joint capsule. The goal of our work was to compare the efficacy of the rehabilitation plans based on standard approaches and rehabilitation plans based on the theory of muscle spirals in patients with the severe pain syndrome and scapulohumeral periarthritis. Materials and methods. We studied 98 patients with scapulohumeral periarthritis. At the first stage of the treatment, all patients received a medical blockade in sites of marked inflammation of para-articular structures. Then, the patients were divided into 2 groups: the patients of group I received a standard rehabilitation in accordance with the recommended regimens using physiotherapy and exercise therapy. The patients of group II took the patient-centred rehabilitation course based on the theory of muscle spirals and the complex effect on spastic muscles. Pain intensity was assessed by visual analogue scale and DASH scale, muscle stiffness was evaluated by compression and shear wave elastography. Results and conclusions. The dynamic changes of pain reduction in patients of group II demonstrated the significant intensity of pain, and a rapid restoration of joint function. The findings of shear wave elastometry showed no difference between the stiffness of the shoulder muscles in the group II after the course of rehabilitation and healthy muscles. Thus, the use of patient-centred rehabilitation plans based on the theory of muscle spirals and a complex effect on spastic muscles enables to achieve a more pronounced effect compared to the standard rehabilitation approaches.
CLINICAL CHARACTERISTICS OF POSTOPERATIVE ANALGESIA IN ELDERLY AND OLD PATIENTS
Authors: Telegan V.O. , Shkurupiy D.A.
Published: July 2019

Nearly 13% of the elderly and old population experience psychosomatic pain that is not regarded as a response to irritants. Diagnosis and treatment of the postoperative pain in old and elderly patients may be complicated by chronic pain or somatic diseases. The aim of this work was to study clinical characteristics of the postoperative pain in old and elderly patients. Materials and methods. This study based on analysis of 99 cases of the perioperative period. Patients were divided into groups by age: the 1st group included individuals aged 18-59 years, the 2nd group included individuals over 60 years. The influence of age, type of anesthesia and postoperative analgesia on the character and severity of pain was determined by questioning and clinical comparison. The Visual Analogue Scale and the McGill questionnaire were used to assess the pain intensity. Results and their discussion: the elderly patients demonstrated higher scores of the affective component to surgical intervention; moreover, the direct relationship between the affective and evaluative components and the indirect correlation of the sensitive component of pain with age was found out. There have been established the significant direct links between postoperative pain and its components in elderly people with the level of pain before surgery, intrathecal anaesthesia, and vascular surgery. Conclusions: in the elderly, in contrast to the younger individuals, the level of postoperative pain is more pronounced. The initial level of pre-operative pain in these patients definitely influences the level of postoperative pain. Simultaneously, the postoperative pain in the elderly is due to the greater lability of all the components of pain, with the prevalence of affective and evaluative components. The persistence of pain in the postoperative period is typical for elderly people who underwent vascular interventions and intrathecal anaesthesia. In the context of the conventional tactics of postoperative pain relief in the elderly people, the strength and the characteristics of the pain are more significantly intense relatively to those in younger patients that require an improvement in the tactics of pain management.
EXTRACEREBRAL ZINC-DEPENDENT DISORDERS AND THEIR CORRECTION IN PATIENTS WITH ACUTE CEREBRAL INSUFFICIENCY
Authors: Teriv P.S.
Published: July 2019

Introduction: zinc metabolism disorders, which often accompany the development of a critical state, may lead to numerous heterogeneous metabolic and functional disorders, both in the nervous system and in the other body systems. Objective: to improve intensive care of patients with acute cerebral insufficiency by correcting extracerebral disorders associated with zinc deficiency. Materials and methods: a clinical randomized cohort study included 94 patients aged 18 years with acute cerebral insufficiency. The concentrations of zinc, thiol compounds, intestinal fatty-acid-binding proteins, and interleukin-1β were analyzed. The dynamic changes of these indicators, their relationships with each other, depending on the underlying pathology and the medical correction of zinc sulphate monohydrate and acetylcysteine, were evaluated. Results and discussion: there was a decrease in zinc and thiol compounds serum level in the examined patients that indicates an impairment of transport zinc regulation and antioxidant defence, an increase in the level of intestinal fatty-acid-binding proteins that is a marker of gastrointestinal damage of the mucous membrane of the tract. These changes, as well as the concentration of interleukin-1β, are interrelated and depend on the zinc concentration. The exogenous introduction of zinc sulphate monohydrate and acetylcysteine promotes the normalization of the parameters studied. Conclusions: Patients with acute cerebral insufficiency have extracerebral disorders in the content of thiol compounds, as well as the disorders of the gastrointestinal mucous membrane and pro-inflammatory response. The exogenous introduction of zinc sulphate monohydrate and acetylcysteine contribute to eliminating such disorders.
FATTY-ACID-BINDING PROTEIN AS A MODERN MARKER FOR DIAGNOSIS AND EFFICACY OF INTENSIVE THERAPY OF GASTROINTESTINAL INSUFFICIENCY SYNDROME IN NEWBORNS
Authors: Kholod D.A.
Published: July 2019

I-FABP, a fatty-acid-binding protein, is considered as a highly sensitive and highly specific marker of damage to the intestinal mucosa and could be used as an informative indicator of its affection in gastrointestinal insufficiency syndrome in newborns. Damage to the mucous membrane in patients requiring intensive care will always be accompanied by the basic mechanisms of critical states, ischemia and hypoxia. The aim of the work was to improve the diagnosis and assessment of the effectiveness of intensive care in newborns with gastrointestinal insufficiency syndrome by determining the I-FABP level. A prospective randomized clinical study included 20 newborns with gastrointestinal insufficiency syndrome. The concentration of blood plasma I-FABP in the examined patients was investigated, depending on the severity of the syndrome and the tactics of intensive care. It was established that the I-FABP concentration in 95% of cases was higher than the physiological value. This marker was significantly increased in newborns with clinically significant gastrointestinal insufficiency syndrome and decreased with lowering manifestations of this syndrome and under modified therapy with succinic acid and lactobacillus probiotics. Thus, an increase in the I-FABP concentration in newborns receiving an intensive care in 95% of cases points out the presence of gastrointestinal insufficiency syndrome that confirms a high sensitivity of the indicator. This marker can be used as a criterion for evaluating dynamics and stages of gastrointestinal insufficiency syndrome, accompanied by organic disorders, as well as a criterion for measuring the therapeutic efficacy for this syndrome.
PROGNOSTIC VALUE OF BIOCHEMICAL MARKERS IN PURULENT-CEPTIC COMPLICATIONS OF ACUTE SEVERE PANCREATITIS
Authors: Cherkun O.Yu. , Sheyko V.D. , Sytnik D.A. , Kryzhanovsky O.A.
Published: July 2019

One of the most pressing issues of urgent abdominal surgery is acute pancreatitis. The incidence of pancreatitis increases annually by 2.5 - 3.1%, ranging from 15 to 70 cases per 100,000 population in Europe and North America. About 40% of patients die within the first 7 days after hospitalization, most in the first 3 days. Patients with acute severe pancreatitis who are experiencing the first wave of the disease have a high risk of secondary infection of the pancreatic necrosis foci that is an indication for surgical intervention. This article presents the analysis of the  treatment results in 22 patients with acute severe pancreatitis, 7 (31.8%) men and 15 (68.2%) women. Age of patients ranged from 22 to 79 years (46,9 ± 1,5 years). 2-7 days was the time from the onset of the disease to hospital admission. Purulent-septic complications developed in 22 (100.0%) patients, the presence of sequestrate was detected in 9 of them (40.9%). The average period of hospital staying for this group of patients was 48.3 ± 4.4 days; the mortality rate was 27.3% (6 patients). Having analyzing the biochemical markers obtained, we can state that the increase in the level of procalcitonin and C-reactive protein indicates the development of purulent-septic complications in patients with acute severe pancreatitis, while the decrease in the free T3 concentration at normal T4 and TSH levels in 6 (27.3%) of patients, suggests the development of their lowT3 syndrome that in turn suggests an unfavourable course of the disease.
Helminthes of the Common Eider (Somateria mollissima) on the Eastern Murman, its impact on the digestive activity and physiological state
Authors: Kuklina M. M. , Kuklin V. V.
Published: July 2019

An ecological and physiological study of Common Eider (Somateria mollissima) nesting on the coast of Eastern Murman was carried out. The species composition of helminthofauna of birds and the quantitative parameters of the infection were studied. It is established that trematodes of the genus Microphallus, three species of cestodes - Lateriporus teres (Cestoda: Dilepididae), Fimbriarioides intermedia (Cestoda: Hymenolepididae), Microsomacanthus diorchis (Cestoda: Hymenolepididae) and one species of acanthocephalan - Polymorphus phippsi (Palaeacanthocephala: Polymorphidae) parasitized in the small intestine of Common Eider. It is shown that the activity of proteases decreased at the locations of F. intermedia and M. diorchis in the intestines of birds, with infestation with the acanthocephalan P. phippsi, on the contrary, increased. The activity of glycosides in the intestinal mucosa was reduced in comparison with the control values by infection cestodes M. diorchis. There was an increase in the values of hematological indices in infected individuals relative to the control parameters.
Peculiarities of pore initiation in р-type silicon during its electrochemical etching
Authors: Abramova E. N. , Khort A. M. , Yakovenko A. G. , Syrov Yu. V. , Tsigankov V. N. , Slipchenko E. A. , Shvets V. I.
Published: July 2019

Peculiarities of porous silicon layers formation during electrochemical etching of p-type silicon were studied. Principal divisions of pore formation mechanisms in n-type and p-type of silicon were demonstrated.
Dinuclear cobalt and iron complexes with azomethine derivative of 1,10-phenanthroline: quantum chemical study
Authors: Starikova А. А. , Chegerev M. G. , Starikov A. G. , Minkin V. I.
Published: July 2019

Geometry, energy and magnetic characteristics of binuclear compounds of 5,6-bis(salicylideneimino)-1,10-phenanthroline with cobalt and iron have been computationally studied by means of density functional theory method (DFT UTPSSh/6-311++G(d, p)). Complexes comprising two magnetically active fragments capable of manifesting spin-crossover and valence tautomerism have been constructed via completion of the coordination sphere of the metal ions with ancillary ligands. These effects provide for variation of spin states in a wide range, which endows the studied compounds properties of molecular switches and spin qubits.
A new approach to performing thermally coupled processes by the example of a granular mixture (Ni+Al)-(Ti+C)
Authors: Alymov M. I. , Seplyarskii B. S. , Kochetkov R. A. , Lisina T. G.
Published: July 2019

For the first time, thermally coupled SHS processes in granulated mixture were experimentally investigated. Mixtures of Ni+Al and Ti+C granules differ in combustion rate and temperature. It has been established that ignition of Ni+Al acceptor granules occurs in the combustion front. It is shown that the use of granular mixtures allows to obtain combustion products in the form of easily destructible sample. Release of the target product turned possible, though the melting point of the product of acceptor mixture interaction is less than the adiabatic temperature of combustion.