bluuebunny/crossref_metadata_2025 huggingface dataset:
The Image of ‘Early Childhood Teachers in Childhood Remote Education’ by Current Early Childhood Teachers
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Eun Jung , Ha Min Kyung
Published: June 2022

Objectives The purpose of this study was to examine how incumbent early childhood teachers who have undergone changes due to COVID-19 image early childhood teachers in remote education.
Methods In this study, metaphor analysis was conducted to find out the human conceptual system and thoughts from the perspective of experientialism. The subject of the study is 172 early childhood teachers with remote education experience. The researcher distributed the research subject a sentence-completed metaphor analysis questionnaire, “In remote education, the early childhood teacher is ( ). Because it is ( ).” After organizing the collected data in Excel, it was analyzed using the conceptual metaphor method(Gok & Erdogan, 2010) that revealed the metaphor tendency and metaphor type. While the researchers repeatedly read the data, the final results were derived through classification, categorization, and recategory.
Results As a result of the study, early childhood teachers perceived early childhood teachers implementing remote education as robots, guides, entertainers, researches, capable of doing anything, leaders, a person who teaches others, and people who would disappear.
Conclusions Through the results of this study, it was revealed that early childhood teachers perceived difficulties and limitations in their roles in early childhood remote education, and various implications were also provided for the new role of early childhood teachers for childhood remote education in the post-COVID-19 era
체험위생교육이 초등 저학년 아동의 개인위생 태도와 실천에 미치는 영향
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Park So Yeon , Park Hye-Ryeon
Published: June 2022

Objectives This study was an interventional study verifying the effects of experiential hygiene education on lower grade of elementary school student’s personal hygiene attitudes and practices
Methods In July 2020, data collection and intervention were conducted among 16 lower grade lower grade elementary students who visited the regional children's center and participated in experiential hygiene education. The data was analyzed using SPSS/WIN 21.0.
Results The analysis showed that the perception of personal hygiene after experiential hygiene education (t = 4.39, p = .001), attitude toward hand hygiene (t = 6.70, p < .001), and degree of practice of hand hygiene (t = 3.02, p = .009) and wearing a mask (t = 7.04, p < .001) were significantly improved.
Conclusions The experiential hygiene education program developed in this study can be used to influence the attitudes toward and practice of personal hygiene, such as hand hygiene and wearing masks, in lower grade elementary students.
Development of Tools to Measure Student Agency for middle and high school students
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Jo Yunjeong , Park Sejin , Jung Woojin
Published: June 2022

Objectives This study aims to develop a tool that can objectively and validly measure student agency for middle and high school students.
Methods To this end, first, a measurement tool was developed by reviewing previous related studies. Next, the content validity was verified through a Delphi survey targeting 12 experts. Finally, data were collected by conducting a student agency test targeting 2,158 middle and high school students located in Gyeonggi-do, and construct validity was verified through confirmatory factor analysis.
Results Three domains of student agency were established: initiative attitude, initiative action, and community agency. Motivation, self-efficacy, self-reflection, and growth mindset are four sub-factors of initiative attitude, while goal formulation, initiative execution, and effort continuity are three sub-factors of initiative behavior. Communication, consideration, cooperation, community consciousness, and involvement are the five sub-factors of community agency. There are 48 items in the student agency measurement tool. As a result of confirming the validity of the test data through confirmatory factor analysis, it was consistent with the student agency factor model established by the research team.
Conclusions Based on the results of this study, educational implications of the student agency measurement tool and utilization plans were discussed.
Influence of Self-Leadership, Critical Thinking on Self-efficacy of Nursing Students in Online learning
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lee Yoonhee , An Na
Published: June 2022

Objectives This study examined the influence of self-leadership and critical thinking disposition on the self-efficacy of nursing students.
Methods The research subjects were 215 nursing students in D city. The data analyzed by an independent t-test, ANOVA, Pearson's correlation, and Hierarchical multiple regression using the IBM SPSS/Win 25.0 program.
Results The results showed that critical thinking disposition was 3.39, self-leadership was 3.58, and self-efficacy was 3.83. The self-efficacy has positive correlations with self-leadership and critical thinking disposition. Critical thinking disposition(β=.0.48, p=.001), self-leadership(β=0.44, p=.021), explained 41.4% of total variance of self-efficacy of nursing students.
Conclusions In order to increase self-efficacy in nursing students, it is necessary to develop a specific strategy to improve self-leadership and critical thinking to develop various activities and programs to immerse students in learning.
Mediating Effect of Cognitive Self-regulation between Academic Self-efficacy and Flourishing of First-year University Students
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Kukhyeon , Lee Jumi
Published: June 2022

Objectives The purposes of this study were to specify variables related to the flourishing of college freshmen and to analyze the structural relationships among academic self-efficacy and cognitive self-regulation strategies.
Methods A total of 370 college freshman survey responses from universities in G city and J province were used to conduct a descriptive analysis, a correlational analysis, mediating effect analysis, a bootstrapping analysis. Flourishing survey responses included sub-five elements PERMA(positive emotion, engagement, relationship, meaning, and achievement). Cognitive self-regulation strategies consisted of four elements(organization, attention, metacognition, and test strategies).
Results Cognitive self-regulation strategies totally mediated the relationship between academic self-efficacy and the flourishing of college freshmen. But there was no direct relationship between academic self-efficacy and the flourishing of freshmen significantly.
Conclusions First, cognitive self-regulation affects directly first-grade undergraduate students’ flourishing. This suggests that the use of specific cognitive self-regulation should be considered to increase flourishing among college students. Second, academic self-efficacy and cognitive self-regulation are highly correlated with the ‘achievement’ factor among the sub-factors of flourishing, which can be seen as more influential on achievement than other sub-factors of flourishing.
Professor’s experience reflecting the 2019 revised Nuri course in the Early Childhood Education Major Curriculum Class
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Park Ae-kyung , Suh Hye-jeong
Published: June 2022

Objectives This study is a narrative inquiry about experience of professors reflecting the 2019 revised Nuri course in the Early Childhood Education Major Curriculum Class.
Methods For this study, one professor from the Department of Early Childhood Education at D University was targeted. Data were collected through in-depth interviews from July 15, 2020 to January 26, 2021. The collected data were analyzed inductively through the process of segmenting, discovery of initial coding, and in-depth coding generation through an open coding methodology.
Results As a result of the study, the difficulties in reflecting the revised Nuri course in the pre-service teacher education are the instructor's lack of experience in the direction of the revised Nuri course, the learner without leading play experience, and the lack of communication in non-face-to-face classes. In spite of these difficulties, the instructor reflected 1) keeping up with the acceptance level of the 2019 revised Nuri course in the field, 2) approaching it as a play case, 3) playing and experiencing the role of a teacher who supports play in the pre-service teacher education. In the reuslts of these studies, Professor K found that 1) presenting an early childhood teacher modeling that the professor supports to play, 2) playing in various group types, 3) playing with various media at the same time, 4) combining activities and play, 5) it is necessary to have an opportunity to experience the meaning of play.
Conclusions This study suggests that the responsibilities of pre-service teacher educators and various efforts should be followed in the 2019 revised Nuri course.
Application of CQI for the realization of competency-based education and it’s effects: Focusing on the case of D University
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Choi Jung-Hui
Published: June 2022

Objectives The purpose of this study is to analyze the effect of the Continuous Quality Improvement report on competency education in universities.
Methods This study was conducted by analyzing the contents of the CQI report prepared for each of the seven common liberal arts subjects opened at University D, and comparing the results of the student's competency diagnosis conducted before and after the application of the CQI report.
Results As a result of the study, it was found that the level of awareness among professors about the CQI report has been steadily improving, and as a result, the narrative content of the report has been greatly improved. Also, it was found that the students' competency scores increased significantly after CQI application compared to before, and the number of competencies that showed an increase in scores also increased.
Conclusions It turns out that the CQI report is an effective tool in promoting competency-based education in universities. The CQI report can be a tool to help improve the curriculum in major subjects as well as common liberal arts subjects, the subject of this study.
A Counsensual Qualitative Study of Client Experience on Video conferencing counseling switched due to COVID-19
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Jeong Kwang-Hoon
Published: June 2022

Objectives The purpose of this study is to explore the clients’ experience of a video conferencing counseling introduced in accordance with the prolonged COVID-19 outbreak. To identify clients’ experience of a video conferencing counseling and provide basic data for the effective approach of video conferencing counseling in the future.
Methods For this purpose, individual interviews were conducted from February 2022 to March 2022 for 7 clients who switched from face-to-face counseling to video conferencing counseling due to COVID-19, and 7 pieces of data were collected. Collected data was analyzed using the Consensual Qualitative Research(CQR).
Results As a result of the analysis, a total of 4 areas and 12 categories were derived. The four areas derived are ‘experience of transition to video conferencing counseling’, ‘digital environment of video conferencing counseling’, ‘video conferencing counseling space environment’, and ‘suggestions for activating video conferencing counseling in the future’. In the ‘experience of transition to video conferencing counseling’, there are three categories of ‘attitude before the transition to video conferencing counseling’, ‘good points compared to face-to-face counseling’, and ‘disadvantages compared to face-to-face counseling’. In the four categories of ‘comfort due to unfamiliar digital environment’, ‘inconvenience due to unstable network environment’, ‘consultation due to unfamiliar digital environment’, ‘visual counseling space environment’ In the two categories of ‘good points’ and ‘disadvantages of counseling in a private space’, ‘suggestions for activating video conferencing counseling in the future’ Three categories of ‘consultation progress’ were derived.
Conclusions Based on the study results, the implications and limitations of counseling were presented. This study compared the experiences of face-to-face and video conferencing counseling through the client's video conferencing counseling conversion experience, and provided implications for an effective approach to video conferencing counseling and understanding the client.
A Study on the Family Caring Experience of Mothers with Early Childhood Children due to the Prolongation of COVID-19
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Shin Nam-joo
Published: June 2022

Objectives In this study, it was conducted to find out the difficulties and needs of mothers experienced due to the prolonged COVID-19.
Methods To this end, five mothers with children attending kindergartens located in the metropolitan area were divided into two groups and conducted in-depth interviews to find out the difficulties and demands of mothers who experienced COVID-19 for more than two years.
Results As a result of the study, the study participants cited first, restrictions on children's outdoor activities and a surge in stress from mothers as the biggest difficulties. Second, they were most worried about their children’s lack of various experiences and peer relationships. Third, they wanted to carry out an appropriate amount of activities and to prepare for elementary school admission in kindergarten. Fourth, they wanted to provide national support for education expenses and emergency family support expenses that must be paid even in the absence of kindergarten, and to operate a platform that proposes activities that can be done with children.
Conclusions Therefore, this study is meaningful in that it presents basic data to understand matters related to family care changed due to the prolonged COVID-19 and to establish measures to cope with pandemic situations such as COVID-19 in the future.
Research on Diversified Relief of Minors in a dilemma after being involved in a criminal case from a procuratorial perspective
Authors:   Wonkwang University Legal Research Institute has, Ni Sha , Yao Qiannan , Liu Yan
Published: June 2022

It is common that rights and interests of minors involved in a criminal case are damaged, leading them into a dilemma of survival, health, education and personal development. With the latest Law of the People’s Republic of China on the Protection of Minors, judicial relief and social relief are forming an effective alignment and jointly building a diversified relief for the minors involved in a criminal case in general. By examining the diversified relief offered for minors by procurtorial organs, analyzing common traits in cases, studying the issues of the relief program including limited scope, unsuited matching, jurisdiction conflict, poor connection with the subjects, promoting expanded relief for the minors, strengthening priority protection awareness, enhancing cross-region communication and coordination, we are aiming to improve the diversified relief effect for minors in such dilemma.
The experience of UNESCO Creative Cities in the context of COVID-19: a case study of Brazilian cities
Authors: Machado Ana Flávia , Guimarães Alice Demattos , Michel Rodrigo Cavalcante Michel Cavalcante , Melo Gabriel Vaz de , Bittencourt Julia Papini
Published: June 2022

This paper aims to analyze Curitiba and Florianopólis, the two oldest UNESCO creative cities in Brazil, in a comparative approach. The propose is to identify in which extent the UNESCO labelling process has contributed to promote the chosen modality and related sectors. Moreover, given the current global pandemic, this study also draws a portrait of before and after COVID-19, especially when it comes to the tourism enterprise. For that, we use secondary data as well as primary data to deal with both cities case studies. Our secondary sources tackles labor market data and tourism flow contextualized to the two territories, exploring the Network's potential, achievements and challenges after the label granting added up the pandemic setting.
Creative districts and creative tourisme
Authors: Piqué Jorge , Richards Greg
Published: June 2022

This paper presents a conversation between Greg Richards and Jorge Piqué on the development of creative districts and their links to creative tourism. The discussion ranged from the genesis of creative districts and creative tourism to contemporary challenges of creative placemaking. It includes a consideration of the development of cultural tourism, and how creative tourism emerged as a separate field of analysis in the new Millennium. As places have sought to distinguish themselves in an increasingly competitive global market, they have turned to creativity as a source of inspiration. Tourists tired of standardised products and crowded cultural sites have sought out the more localised experiences provided by creative districts and creative tourism. Creative districts have therefore become a vital tool for placemaking, providing access to the ‘extraordinary everyday’ and generating new models of creative tourism.
Turismo & pandemia: o repensar do turismo nos Vales da Uva Goethe (SC)
Authors: Medeiros Mirna de Lima , Vieira Adriana Carvalho Pinto , Silva Hellen Vitória
Published: June 2022

O Turismo, ao mesmo tempo que foi um dos responsáveis pela disseminação da COVID-19, foi também um dos mais impactados pelas medidas necessárias para sua contenção (como fechamentos, barreiras sanitárias, limitações de atividades e público, etc.). Por outro lado, pode ser parte da solução para reparar economias em um contexto pós-pandêmico. Essa oportunidade, contudo, vem acompanhada de novas demandas do consumidor, bem como do meio acadêmico que já vinha apresentando algumas críticas com relação a determinados modelos de massa. Em decorrência de tais demandas, o reinício do Turismo tende a priorizar destinos mais próximos dos núcleos emissores de turistas e que oportunizem vivências em espaços amplos e, de preferência, ao ar livre. Diante desse cenário, analisar como estão destinos com essa característica e se estão se preparando para esse momento (que ainda é futuro no país), pode ser relevante. Assim, o presente trabalho objetivou verificar as alterações decorrentes da pandemia da COVID-19 no enoturismo dos Vales da Uva Goethe. Essa região detém indicação geográfica para vinhos e espumantes, elaborados com uma uva híbrida e endêmica, e se situa entre o litoral e a serra catarinense podendo ser uma alternativa de destino dentro das tendências apontadas. O estudo de caso exploratório-descritivo teve coleta de dados por meio de análise documental, entrevistas e observação direta in loco. Os resultados apontam que o período de pandemia, apesar de ter trazido aumento de custos e períodos de fechamento, oportunizou um repensar e até renovar, já que se encontraram novas atividades, parcerias público-privadas e reformas.
Carnaval e turismo criativo: O case Bloco da Ovelha em Caxias do Sul-RS [Brasil]
Authors: Kukul Vanessa Cristina , Gastal Susana de Araújo
Published: June 2022

O turismo e a cultura foram os setores mais afetados pela Pandemia Covid19, que alcançou o Brasil em março de 2020. O Carnaval, manifestação popular e urbana, com importante representatividade cultural e turística, esteve entre as manifestações mais afetadas, razão pela qual as agremiações têm procurado estabelecer novas estratégias como forma de sobrevivência da festividade. Nestes termos, este artigo tem como objetivo compreender as estratégias do Bloco da Ovelha, agremiação carnavalesca que desfila em Caxias do Sul, no Estado do Rio Grande do Sul, Brasil, considerando os tempos de pandemia, para recuperação dos negócios. Para tal, os procedimentos de pesquisas, qualitativos e exploratórios, do tipo estudo de caso, envolveram pesquisa bibliográfica e entrevista semiestruturada com o diretor artístico do Bloco. Resultados preliminares indicam que os gestores têm proposto a realização de oficinas de dança e percussão, moda e artesanato, entre outras, abrangendo diferentes públicos e diversidade de saberes e fazeres artísticos associados ao Carnaval. A realização das oficinas dialoga com o turismo criativo, contribuindo para o seu fomento e para sustentabilidade do Bloco, assim como da cadeia produtiva decorrente.
Integrasi Program Berkelanjutan Dalam Penanganan Kawasan Permukiman Kumuh di Kecamatan Tungkal Ilir
Authors: Muhammad Munzil Nur , Napitulu Dompak , Rosyani Rosyani
Published: June 2022

The area of ​​the slum area in Tungkal Ilir District, Tanjung Jabung Barat Regency is 225.4 ha. The condition of buildings, environmental roads, environmental drainage, clean water, sanitation, solid waste and fire protection, are indicators of slum levels. In accordance with these indicators, the relevant Regional Apparatus Organizations (OPD) carry out programs in efforts to deal with slums. The purpose of this study is to analyze the effect of slum settlement management programs on the sustainability of slum area handling programs. The sampling method used is purposive sampling with 100 community respondents in slum locations and Stratified sampling with 30 ASN respondents, this study uses questionnaires and interviews with related parties in data retrieval. Analysis test uses SEM (Structural Equation Modeling) method and data processing using SmartPLS (Partial Least Square) software. The results showed the t-statistic for the Integration Program variable towards the Sustainable Cities variable was 2.185> t-statistic (1.96). The original sample estimate value shows a positive value (0.199). which shows that the relationship pattern of the integration of the program handling slum areas with the sustainability of the program is positive, with a moderate level. The results show that the integration of the program indirectly affects sustainable cities through community participation and slum areas that have not been implemented optimally and tend to be in the middle so that programs and activities that are integrated and synergized by the Regional Government in implementing sustainable cities still need to be implemented.

Keywords: Integration, Sustainable, Handling, Slums.
Partisipasi Masyarakat Dalam Program Penyediaan Air Bersih Dan Sanitasi (Studi Di Kecamatan Ujung Pangkah Kabupaten Gresik)
Authors: Anggraini Cecilia
Published: June 2022

Program penyediaan air bersih dan sanitasi berbasis masyarakat merupakan salah satu program unggulan pemerintah pusat yang menggunakan pendekatan berbasis masyarakat, dimana masyarakat sebagai pelaku utama dan sekaligus sebagai penanggungjawab pelaksaan kegiatan. Partisipasi masyarakat merupakan kepedulian masyarakat terhadap kualitas lingkungan, seperti ikut serta dalam segala macam kegiatan sosial yang diadakan di lingkungan permukiman. Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian deskriptif. Teknik pengumpulan data dilakukan melalui observasi, wawancara dan dokumetasi. Lokasi penelitian ini berada di Kecamatan Ujung Pangkah Kabupaten Gresik. Hasil temuan dari penelitian ini yaitu bahwa program penyediaan air bersih dan sanitasi, merupakan suatu program yang dibentuk oleh peemrintah pusat yang didukung oleh PGN Saka dengan mengutamakan masyarakat sebagai aktor yang sangat berperan penting dalam mengupayakan pembangunan dan penyediaan air bersih serta perbaikan sarana dan prasarana sanitasi terutama di Kecamatan Ujung Pangkah. Bentuk partisipasi yang dilakukan oleh masyarakat berupa: Partisipasi dalam bentuk tenaga, Partisipasi dalam bentuk materi, dan Partisipasi dalam bentuk kegiatan sosial. Faktor yang mendasari masyarakat untuk ikut berperan aktif di dalam program penyediaan air bersih dan sanitasi diantaranya: Kemauan dan kemampuan masyarakat untuk mengubah atau memperbaiki keadaan serta program tersebut disambut baik oleh masyarakat sekitar mengingat adanya sebagian wilayah yang kekurangan air bersih.
Analisis sistem pengelolaan limbah medis padat Puskesmas di Kabupaten Tanjung Jabung Barat ( Studi kasus di Puskesmas Rawat Inap Purwodadi Kec. Tebing Tinggi, Kab. Tanjung Jabung Barat )
Authors: Yanto Edisar , Syarifuddin Hutwan , Muhaimin Muhaimin
Published: June 2022

ABSTRAK

Operasional Puskesmas akan menimbulkan limbah, yang berpotensi menimbulkan dampak terhadap masyarakat dan lingkungan hidup. Tujuan penelitian untuk menyusun strategi pengelolaan limbah medis padat di Puskesmas Rawat Inap Purwodadi. Metode penelitian kualitatif  dengan pendekatan deskriptif, pelaksanaan penelitian bulan Oktober-November 2019. Populasi  dalam penelitian ini semua pegawai yang bekerja di Puskesmas Rawat Inap Purwodadi. Teknik pengambilan  informan menggunakan tekhnik Purposive sampling. Hasil penelitian, evaluasi faktor internal  diperoleh selisih kekuatan dan kelemahan adalah -45, sedangkan selisih faktor eksternal  peluang dan ancaman adalah +44, posisi penilaian faktor internal dan ekternal berada pada kuadran III (Negatif, positif). Dengan posisi ini  strategi yang mendukung  adalah turn around, artinya strategi pengelolaan limbah Puskesmas dapat disusun dengan memanfaatkan lokasi Puskesmas yang  luas, tersedianya dana dan peraturan untuk memenimalkan kelemahan yang ada . Kesimpulan strategi yang mendukung pengelolaan limbah medis padat di Puskesmas dapat dilakukan dengan  menjadikan PP No. 101 Tahun 2014 dan Permen LHK No. P.56 Tahun 2015 sebagai dasar pengelolaan limbah medis padat di Puskesmas, Peningkatan kapasitas SDM , peningkatan dukungan alokasi anggaran, Peningkatan Pengawasan kepatuhan petugas  dalam menggunakan APD, dan usulan Pengadaan fasilitas pengelolaan limbah serta pemantapan kerja sama dengan pihak ketiga.

Kata kunci : sistem pengelolaan limbah, limbah medis padat puskesmas dan analisis SWOT
ANALISIS KEBERLANJUTAN USAHATANI SAYURAN KANGKUNG DI KECAMATAN PAAL MERAH KOTA JAMBI
Authors: Puja Winata Dwi , Suandi Suandi , Tatik Maryani Anis
Published: June 2022

This study aims to describe farming activities kale in District Paal Merah city of Jambi, knowing sustainability index farm kale from the dimensions of the ecological, economic and social, as well as to determine the factors that affect adoption of sustainable farming kale in District Paal Merah city of Jambi. Methods of data analysis using descriptive analysis and quantitative analysis using MDS (Multi Dimension Scale) doped with Rapfish application. In addition, to determine the factors that affect the linear regression.

The result showed that: (1) The results of the analysis of vegetable farming income in the study area showed that vegetable farming that farmers provide benefits for farmers. The average farmer's income earned in the District of Paal Red kale Rp. 1.231.125,67;-, with the cost of Rp. Rp. 910.728,50;- and the reception received by farmers Rp 2.141.854,17;-. (2) The results of the analysis of the value of sustainable farming in the district kale Red Paal at 61.42. The figure shows the level of integration of sustainability kale farm in the District of Red Paal quite sustainability. With the analysis of the ecological dimensions of sustainability index of 71.27%, 57.10% of the economic dimension and the social dimension of 55.88%. (3) Based on the results of t-test analysis showed that, the value of sustainable farming in the district kale Red Paal farmers are affected by age. When viewed from the significance value then age watercress farmers have significant influence with age farmers. While the experience factor, farmers' income and education did not significantly affect the farmers to adopt sustainable farming values kale.

Keywords: farming kale, sustainability index, factors that affecting
Test
Authors: Emma Cocker
Published: June 2022

published in: TestTestTestTestTestTestTest
Clinical significance and pitfalls of human chorionic gonadotropin related tumor markers for intracranial germinomas
Authors: Suzuki Tomonari , Shirahata Mitsuaki , Adachi Jun-ichi , Mishima Kazuhiko , Nishikawa Ryo
Published: June 2022

Objective Measuring serum and cerebrospinal fluid human
chorionic gonadotropin (hCG) is essential for the diagnosis of
intracranial germ cell tumors. There are three types of hCG-related
markers in clinical use: hCGβ, intact hCG, and total hCG. The best
marker for the diagnosis of intracranial germ cell tumors, especially
germinoma, is currently unknown. This study aimed to evaluate the
usefulness of these hCG-related markers. Materials and Methods
We report six patients with histologically diagnosed germinoma treated
at our institute. Serum hCGβ, intact hCG, and total hCG were measured
before, during, and after treatment. Results The positivity
rates of serum hCGβ, intact hCG, and total hCG were 6% (1/17), 47%
(7/15), and 42% (8/19), respectively, with the latter two having
significantly higher positivity rates than hCGβ (p = 0.041). Both intact
and total hCGs showed similar values. The median value of hCGβ, intact
hCG, and total hCG before treatment was 0.1 ng/mL, 4.6 mIU/mL, and
4.5 mIU/mL, respectively. Conclusion Serum intact and total
hCGs have higher detection rates than hCGβ for patients with germinoma
using available commercial measurement tools.
Wavelet Integrated Adder Neural Networks for Better Image Classification
Authors: Li Guangping , Liang Dingkai
Published: June 2022

Adder neural networks is a new kind of deep learning model in which the
original massive multiplications in convolutions are replaced by
additions. The overall energy consumption using adder networks is
reduced significantly. However, there is an accuracy drop in image
classification task. In this letter, we present a add-wavelet transform
block (AWT) instead of the existing down-sampling operations. Based on
the AWT, we propose a novel adder neural networks (AddWaveNets) to
improve classification accuracy. Experimental results on CIFAR datasets
show that our proposed AddWaveNets achieves significant improvements in
classification accuracy and a powerful ability of feature learning
compared to state-of-the-art quantization networks.
Research on Spot Market Price Forecasting Method Considering the Electricity Purchase-Gain for Demand-side
Authors: Wang Ning , Du Yuan , Wang Haohao , Zhu Tao , Wu Mingxing , Yang Saite
Published: June 2022

The clearing price in electricity spot market is an important reference
that guides marker participants in making energy purchase. Current
electricity price forecasting methods consider the numerical accuracy of
the forecast result only, ignoring the need to optimize economic
benefits, while higher numerical precision sometimes leads to lower
electricity-purchase gain. This paper proposes a price forecasting
method that considers both economic benefits and numerical accuracy. A
function representing the relationship between the predicted electricity
prices and the cost reference for making energy purchase decisions is
calculated, and then introduced to the loss function of the prosumers’
forecasting model as a revenue-optimizing term. A sequence comparison
neural network structure is designed and added to consumers’ forecasting
model, so that the results of numerical prediction and comparison both
contribute to predicting better prices. By co-optimizing numerical
precision and electricity-purchase gain, the prediction is more
conducive to reducing the cost of purchasing power. Actual electricity
market price data are used to verify the feasibility of the proposed
forecasting method in improving economic benefits.
Oil field power load prediction based on LSTM under abnormal data cleaning technology
Authors: Yang Yang , wei li
Published: June 2022

In view of the massive load data ofoilfield distribution network
contains various types of outliers, which is not conducive to load
prediction, electric energy decision-making, dispatching and production,
it is very necessary to identify and correct abnormal loads to improve
the validity and reliability of load data and establish a safe,
efficient and sustainable power system.Based on the above reasons, this
paper proposes a data anomaly identification and scene generation method
combining boxplot and generative adversance network (WGAN). This method
firstly uses boxplot method to complete anomaly identification of active
power, reactive power, current and other data of oilfield grid.Then,
wasserstein-based generative Adversation network (WGAN) algorithm was
used to achieve data fitting and generation, which provided data support
for subsequent long-and-short Term Memory (LSTM) based load prediction
model. Finally, the effectiveness of the proposed algorithm and model
was verified by an example of an oilfield power grid.Through the
intelligent identification, sequence generation and load prediction of
oil field load data, the purpose of deep mining and analysis of oil
field production behavior is realized.
Scale dependent niche conservatism found in a lake fish community
Authors: Yang Tingyue , Zhu Lan , Yu Dan , Wang Chunling , Cai Qinghua , Liu Huanzhang
Published: June 2022

Investigations to niche evolution have received controversial results in
recent times, leading to some confusions in ecological studies:
competitive exclusion principle (CEP) predicts that closely related
species should be adequately divergent; while niche conservatism (NC)
predicts that closely related species should be ecologically most
similar. In the present study, by using stable isotope to signify
trophic niche, we analyzed niche divergences of 57 fishes from a lake
(Poyang Lake, central China) at the phylogenetic scale, as well as niche
divergences and overlaps of 7 fishes (same subfamliy) at 5 sites of this
lake, and comprehensively investigated the concepts of NC and
competitive exclusion principle (CEP). The results showed that, NC
exists on a large scale (trophic differences showing positive
relationships with genetic distances), but not at the local scale
(sister species showing larger differences than closely related species,
and almost no trophic overlap), where the CEP works better. Besides,
trophic convergence was also found between some very distantly related
species, leading to the possible limited divergence. We believe these
findings will contribute to future theoretical and empirical niche
explorations.
Geometric morphometrics out-perform linear-based methods in the taxonomic resolution of a mammalian species complex
Authors: Viacava Pietro , Blomberg Simone , Weisbecker Vera
Published: June 2022

Morphology-based taxonomic research frequently applies linear
morphometrics (LMM) in skulls to quantify species distinctions. The
choice of which measurements to collect generally relies on the
expertise of the investigators or a set of standard measurements, but
this practice may ignore less obvious or common discriminatory
characters. In addition, taxonomic analyses often ignore the potential
for subgroups of an otherwise cohesive population to differ in shape
purely due to size differences (or allometry). Geometric morphometrics
(GMM) is more complicated as an acquisition technique, but can offer a
more holistic characterization of shape and provides a rigorous toolkit
for accounting for allometry. In this study, we used linear discriminant
analysis to assess the discriminatory performance of four published LMM
protocols and a 3D GMM dataset for three clades of antechinus known to
differ subtly in shape. We assessed discrimination of raw data (which
are frequently used by taxonomists); data with isometry removed; and
data after allometric correction. We found that group discrimination
among raw data was high for LMM, possibly inflated relative to GMM when
visualised in PCA plots. However, GMM produced better results in group
discrimination after the size and allometry treatments. High measurement
redundancy in LMM protocols appears to result in relatively high
allometry but low discriminatory performance. These findings suggest
that taxonomic measurement protocols might benefit from GMM-based pilot
studies, because this offers the option of differentiating allometric
and non-allometric shape differences between species, which can then
inform on the development of the easier-to-apply LMM protocols.
Rethinking the nature of intraspecific variability and its consequences on species coexistence
Authors: Girard-Tercieux Camille , Maréchaux Isabelle , Clark Adam , Clark James , Courbaud Benoît , Fortunel Claire , Guillemot Joannes , Kunster Georges , Maire Guerric Le , Pélissier Raphaël , Rüger Nadja , Vieilledent Ghislain
Published: June 2022

Context Intraspecific variability (IV) has been proposed to explain
species coexistence in diverse communities. Assuming, sometimes
implicitly, that conspecific individuals can perform differently in the
same environment and that IV blurs species differences, previous studies
have found contrasting results regarding the effect of IV on species
coexistence. Objective We aim at showing that the larg IV observed in
data does not mean that conspecific individuals are necessarily
different in their response to the environment and that the role of
high-dimensional environmental variation in determining IV has been
largely underestimated in forest plant communities. Methods and Results
We first used a simulation experiment where an individual attribute is
derived from a high-dimensional model, representing “perfect
knowledge” of individual response to the environment, to illustrate how
a large observed IV can result from “imperfect knowledge” of the
environment. Second, using growth data from clonal Eucalyptus
plantations in Brazil, we estimated a major contribution of the
environment in determining individual growth. Third, using tree growth
data from long-term tropical forest inventories in French Guiana, Panama
and India, we showed that tree growth in tropical forests is structured
spatially and that despite a large observed IV at the population level,
conspecific individuals perform more similarly locally than compared
with heterospecific individuals. Synthesis As the number of
environmental dimensions that are typically quantified is generally much
lower than the actual number of environmental dimensions influencing
individual attributes, a great part of observed IV might be
misinterpreted as random variation across individuals when in fact it is
environmentally-driven. This mis-representation has important
consequences for inference about community dynamics. We emphasize that
observed IV does not necessarily impact species coexistence per se but
can reveal species response to high-dimensional environment, which is
consistent with niche theory and the observation of the many differences
between species in nature.
Cervical Vagal schwannoma, a rare differential of a neck swelling: a case report
Authors: Prajapati Ramesh , Thapa Aakar , Yadav Jayant , Shrestha Prakash , Lama Manik , KC Ashmita , Gurung Pritam , Pant Basant
Published: June 2022

Cervical vagal schwannoma is a rare clinical entity which requires
different clinical approach than other neck swellings. Magnetic
resonance Imaging is the preferred initial diagnostic test.
Complications may arise due to vagal stimulation in unsuspecting open
biopsies. Surgical excision with perioperative vagal monitoring is
recommended for treatment of vagal schwannomas.
Erianin, a promising agent in the treatment of glioblastoma multiforme triggers apoptosis in U373 and A172 glioblastoma cells
Authors: Serter Kocoglu , Seçme Mücahit , Elmas Levent
Published: June 2022

Glioblastoma is an aggressive, common and deadly primary intracranial brain tumor in adults. The antitumor activity of erianin, a dibenzyl compound found in Dendrobium chrysotoxum Lindl. extract, has not been previously demonstrated in glioblastoma. We investigated the anticancer activity and underlying mechanisms of erianin in human U373 and A172 glioma cells. The effects of erianin on cell viability, apoptosis, migration and invasion were estimated by the XTT test, the reverse transcription-polymerase chain reaction (RT-PCR), annexin V staining assay protocol for apoptosis, wound healing assay, and Matrigel? invasion chamber, respectively. The effective amounts of erianin in U373 and A172 cells were 16 and 64 ?M at 48 h, respectively. Erianin also significantly induced apoptosis by inhibiting B-cell lymphoma 2 (Bcl-2), caspase-8, caspase-9 and tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD), and activation of caspase-3 and BH3 interacting domain death agonist (BID) gene expression. In addition, erianin significantly increased the number of apoptotic cells in U373 and A172 cells and significantly decreased invasion and migration in U373 and A172 cells. Taken together, our results suggest that erianin may be a new therapeutic anticancer drug component with a potent apoptotic effect and a potential for treating glioblastoma.
Changes in the Coexpression of Innate Immunity Genes During Persistent Islet Autoimmunity Are Associated With Progression of Islet Autoimmunity: Diabetes Autoimmunity Study in the Young (DAISY)
Authors: Carry Patrick M. , Waugh Kathleen , Vanderlinden Lauren A. , Johnson Randi K. , Buckner Teresa , Rewers Marian , Steck Andrea K. , Yang Ivana , Fingerlin Tasha E. , Kechris Katerina , Norris Jill M.
Published: June 2022

Longitudinal changes in gene expression during islet autoimmunity (IA) may provide insight into biological processes that explain progression to type 1 diabetes (T1D). We identified individuals from Diabetes Autoimmunity Study in the Young (DAISY) who developed IA, autoantibodies present on two or more visits. Illumina’s NovaSeq 6000 was used to quantify gene expression in whole blood. With linear mixed models we tested for changes in expression after IA that differed across individuals who progressed to T1D (progressors) (n = 25), reverted to an autoantibody-negative stage (reverters) (n = 47), or maintained IA positivity but did not develop T1D (maintainers) (n = 66). Weighted gene coexpression network analysis was used to identify coexpression modules. Gene Ontology pathway analysis of the top 150 differentially expressed genes (nominal P < 0.01) identified significantly enriched pathways including leukocyte activation involved in immune response, innate immune response, and regulation of immune response. We identified a module of 14 coexpressed genes with roles in the innate immunity. The hub gene, LTF, is known to have immunomodulatory properties. Another gene within the module, CAMP, is potentially relevant based on its role in promoting β-cell survival in a murine model. Overall, results provide evidence of alterations in expression of innate immune genes prior to onset of T1D.
Fasting Substrate Concentrations Predict Cardiovascular Outcomes in the CANagliflozin cardioVascular Assessment Study (CANVAS)
Authors: Ferrannini Ele , Baldi Simona , Scozzaro Tiziana , Tsimihodimos Vasilis , Tesfaye Fisseha , Shaw Wayne , Rosenthal Norman , Figtree Gemma A. , Neal Bruce , Mahaffey Kenneth W. , Perkovic Vlado , Hansen Michael K.
Published: June 2022

OBJECTIVE

To examine whether the circulating substrate mix may be related to the incidence of heart failure (HF) and cardiovascular (CV) mortality and how it is altered by canagliflozin treatment.

RESEARCH DESIGN AND METHODS

We measured fasting glucose, free fatty acids (FFA), glycerol, β-hydroxybutyrate, acetoacetate, lactate, and pyruvate concentrations in 3,581 samples from the CANagliflozin cardioVascular Assessment Study (CANVAS) trial at baseline and at 1 and 2 years after randomization. Results were analyzed by univariate and multivariate Cox proportional hazards models.

RESULTS

Patients in the lowest baseline FFA tertile were more often men with a longer duration of type 2 diabetes (T2D), higher urinary albumin excretion, lower HDL-cholesterol levels, higher history of CV disease (CVD), and higher use of statins and insulin. When all seven metabolites were used as predictors, FFA were inversely associated with incident hospitalized HF (hazard ratio [HR] 0.33 [95% CI 0.21–0.55]), while glycerol was a positive predictor (2.21 [1.45–3.35]). In a model further adjusted for 16 potential confounders, including prior HF and CVD and pharmacologic therapies, FFA remained a significant negative predictor. FFA and glycerol also predicted CV mortality (HR 0.53 [95% CI 0.35–0.81] and 1.81 [1.26–2.58], respectively) and all-cause death (0.50 [0.36–0.70] and 1.64 [1.22–2.18]). When added to these models, background insulin therapy was an independent positive predictor of risk of death. Canagliflozin treatment significantly increased plasma FFA and β-hydroxybutyrate regardless of background antihyperglycemic therapy.

CONCLUSIONS

A constitutive metabolic setup consisting of higher lipolysis may be beneficial in delaying or preventing hospitalized HF; a further stimulation of lipolysis by canagliflozin may reinforce this influence.
Changes in Glucose Metabolism and Glycemic Status with Once-Weekly Subcutaneous Semaglutide 2.4 mg Among Participants with Prediabetes in the STEP Program
Authors: Perreault Leigh , Davies Melanie , Frias Juan P. , Laursen Peter Nørkjaer , Lingvay Ildiko , Machineni Sriram , Varbo Anette , Wilding John P.H. , Wallenstein Signe Olrik Rytter , Roux Carel W. le
Published: June 2022

Objective

This analysis of 3,375 adults with overweight/obesity across the STEP 1, 3, and 4 trials evaluated whether more participants with prediabetes had normoglycemia after 68 weeks’ treatment with once-weekly semaglutide 2.4 mg plus lifestyle intervention versus placebo, and assessed changes in glucose metabolism in participants with prediabetes. 

Research Design and Methods

STEP 1, 3, and 4 were phase 3, 68-week, randomized, placebo-controlled, multinational trials; STEP 4 had a 20-week semaglutide run-in and 48-week randomized period. Analyses included changes (week 0–68; before the washout period) in glycemic status (prespecified: STEP 1 and 3; post-hoc: STEP 4), and in HbA1c, fasting plasma glucose (FPG), and insulin resistance (HOMA-IR) among participants with prediabetes (post-hoc).

Results

Significantly more participants with baseline (week 0) prediabetes (n=1,536) had normoglycemia at week 68 with semaglutide versus placebo (STEP 1, 84.1% vs. 47.8%; STEP 3, 89.5% vs. 55.0%; STEP 4, 89.8% vs. 70.4%; all P < 0.0001). Fewer participants with baseline normoglycemia had prediabetes at week 68 with semaglutide versus placebo (STEP 1, 2.9% vs. 10.9%; STEP 3, 3.2% vs. 5.8%; STEP 4, 1.1% vs. 5.0%). Semaglutide resulted in greater improvements in HbA1c, FPG, and HOMA-IR than placebo among participants with baseline prediabetes (all P < 0.01).

Conclusions

STEP 1, 3, and 4 collectively provide a robust assessment of the effects of semaglutide on glucose metabolism and prediabetes in a large cohort of adults with overweight/obesity while on treatment. Among participants with baseline prediabetes, 68 weeks’ treatment with semaglutide vs. placebo led to significant improvements in glucose metabolism and a higher likelihood of normoglycemia.