bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring the action of new FimH inhibitors against CTX– 15 enzyme by enzoinformatics approach: A plausible arsenal against drug-resistant uropathogenic bacterial strains
Authors: Saeed Amir , Alshaghdali Khalid , Saeed Mohd , Alreshidi Mousa
Published: December 2021

Purpose: To explore the potency of FimH inhibitors against CTX-M β-lactamase enzyme type 15, in view of the increasing prevalence of CTX-M 15 in uropathogenic strains which has reduced the treatment options to minimal.Method: FimH inhibitors were targeted against CTXM-15 by a molecular docking approach. Thereafter, the best ligand-target confirmation was selected and analyzed using LIGPLOT+ Version v.2.1. The hydrophobic and hydrogen bonding among the catalytic site amino acids of CTXM-15 and the FimH inhibitors were analyzed and 3-D structures were converted into 2-D images by LIGPLOT algorithm.Results: Out of all the FimH inhibitors tested, 3′-chloro-4′- (α-D-mannopyranosyloxy) biphenyl-4- carbonitrile, para-biphenyl-2-methyl-3′-methylamidemannoside, para-biphenyl-2-methyl-3′,5′dimethylamide-α-D-mannoside, and thiazolylamino mannoside exhibited better interaction with the CTX-M15 active site than the positive control avibactam. Moreover, in CTX-M 15, the amino acid residues, Ser70, Tyr105, Ser130, Asn132, Thr216, Thr235, Gly236, and Ser237 were commonly interacting with these FimH inhibitors as well as avibactam.Conclusion: The predicted findings suggest that these FimH inhibitors could be explored as potential CTX-M 15 inhibitors to cope-up with resistance issues of uropathogenic bacteria in the form of an alternate strategy.
A comparative study of HPLC-DAD and UPLC-UV methods for simultaneous determination of 11 polyphenols in Moringa oleifera leaves
Authors: Zhu Yanqin , Yin Qinhong , Yang Yaling
Published: December 2021

Purpose: To develop, validate and compare two chromatographic methods - high performance liquid chromatography with diode array detector ((HPLC-DAD) and high performance liquid chromatography with ultraviolet detection (UPLC-UV) for the effective analysis of polyphenols in Moringa oleifera leaves.Methods: HPLC-DAD and UPLC-UV methods were applied for the accurate determination of eleven major polyphenols in Moringa oleifera leaves. The chromatographic conditions of the eleven polyphenols was determined on two C18 column by gradient elution with 0.5 % phosphoric acid solution -acetonitrile as the eluate, and at a flow rate of 1.0 and 0.5 mL/min for HPLC-DAD and UPLC-UV methods, respectively. Detector parameter of UPLC-UV was fixed at 203 nm. The assay methods were validated systematically.Results: The instrumental methods (HPLC-DAD and UPLC-UV) had good linearity, precision,repeatability and recovery. For both methods, quantification limits of UPLC-UV (0.057 - 0.363 μg/mL) were lower than those of UPLC-UV (0.094 - 1.532 μg/mL). The UPLC method with a shorter running time and more sensitive detection was applied in comparing to the HPLC method. After optimization and evaluation, the baseline of 11 compounds was separated effectively within 68 and 34 min, respectively.Conclusion: The developed HPLC-DAD and UPLC-UV assays were successfully utilized for thesimultaneous analysis of eleven major polyphenols and can readily be utilized as quality control tools for Moringa oleifera leaves in China, with UPLC-UV method showing better separation, lower organic solvent usage and shorter analytical period.
CircZNF652 accelerates the proliferation and migration of primary lung carcinoma cells by downregulating miR-766
Authors: Hong Xiaobing , Chen Yongqing , Zhang Danzhen
Published: December 2021

Purpose: To explore the biological functions and molecular mechanism of circZNF652 involvement in primary lung carcinoma.Methods: CircZNF652 levels in primary lung carcinoma cases and controls were determined using quantitative real-time polymerase chain reaction (qRT-PCR). Its prognostic value in primary lung carcinoma was examined by depicting it with Kaplan-Meier curves. The biological functions of circZNF652 in regulating proliferative and migratory capacities in A549 and SPC-A-1 cells were analyzed from the curves. Interaction between circZNF652 and its downstream gene, miR-766, wasassessed, and their co-regulation on primary lung carcinoma was determined by rescue experiments.Results: CircZNF652 was abnormally and significantly upregulated in primary lung carcinoma cases (p< 0.05), resulting in a poor prognosis. The knockdown effect of circZNF652 attenuated the proliferative and migratory capacities of A549 and SPC-A-1 cells, and downregulated epithelial-mesenchymal transition (EMT)-associated genes. CircZNF652 bound and negatively regulated miR-766, a keydownstream gene involved in circZNF652-induced aggravation of primary lung carcinoma.Conclusion: CircZNF652 serves as an oncogene, triggering the aggravation of primary lung carcinoma by negatively regulating miR-766. The results of this study may provide new insights into the treatment of lung carcinoma.
Immune thrombocytopenia associated with COVID-19 mRNA vaccine tozinameran – a clinical case and global pharmacovigilance data
Authors: Battegay Raphael , Istampoulouoglou Ioanna , Holbro Andreas , Buser Andreas , Hirsiger Julia R. , Eckstein Jens , Berger Christoph T. , Koechlin Sarah , Leuppi-Taegtmeyer Anne B.
Published: December 2021

We report the occurrence of immune thrombocytopenia (ITP) in a 77-year-old man a few days after receiving the first dose of the COVID-19 mRNA vaccine tozinameran (Comirnaty®). The patient was treated with systemic corticosteroids, intravenous immunoglobulins and eltrombopag. He elected to proceed with the second dose of tozinameran 14 weeks after the first and his platelet count remained stable under a tapered eltrombopag dose. To our knowledge, this is the first case in which a second tozinameran dose has been administered to a patient who developed presumed secondary ITP after the first vaccination. We also report global pharmacovigilance data for the occurrence of ITP after vaccination with tozinameran.
Modlitewniki dla Żydówek w języku polskim, ich autorzy i użytkowniczki. Casus Żydów warszawskich połowy XIX wieku
Authors: Rybińska Agata
Published: December 2021

Prayer Books for Jewish Women in Polish, Their Authors and Users: The Case of Jews in Warsaw in the Mid-Nineteenth Century

In the nineteenth century, only two prayer books for Jewish women and girls were published in the Polish language: one written by Jakub Elsenberg (Warsaw 1855) and the other by Rozalia Saulson (Warsaw 1861). This small numer contrasts with the numerous editions of tkhines in Yiddish and Andachts- and Gebetbücher in German. The aim of the paper is to discuss the circumstances of the creation of both books and specificity of these editions. The origins of the users of the Warsaw’s prayer books according to the list of subscribers (and using the data of genealogical sources) are also considered.
Projektowanie struktury przestrzeni publicznej jednostek urbanistycznych jako warunek skutecznego przekształcenia terenów poprzemysłowych na przykładzie obszaru Pelcowizny w Warszawie
Authors: Trębacz Paweł
Published: December 2021

W obecnie funkcjonującym systemie planistycznym brakuje opracowań pozwalających na określenie głównej struktury przestrzennej większych jednostek urbanistycznych. W wyniku analizy procesu planowania struktury przestrzeni publicznej i czynników wpływających na skuteczne przekształcenie terenów poprzemysłowych autorzy dowodzą, że właściwym narzędziem do przekształcenia większych i zintegrowanych jednostek urbanistycznych miasta byłby odpowiednik dawnego planu ogólnego. Podstawową treścią, która powinna być zawarta w takim planie jest struktura funkcjonalno-przestrzenna, definiująca w szczególności formę i układ przestrzeni publicznej miasta. Analizowane w tekście przykłady planów Pelcowizny o charakterze ogólnym w powiązaniu z planem operacyjnym, w których wyodrębniono hierarchiczne struktury przestrzenne, wykazują konieczność objęcia ogólnymi wytycznymi całej jednostki urbanistycznej i są przykładem na jej efektywniejsze zagospodarowanie. Artykuł kończy propozycja metody dotyczącej sposobu konstruowania struktury przestrzeni publicznej miasta i warunkującej skuteczne przekształcenie terenów poprzemysłowych. Designing of the public space structure of urban units as the condition for effective transformations of post-industrial zone on the example of Pelcowizna area in Warsaw In the currently functioning planning system there is a lack of studies enabling to determine the main spatial structure of larger urban units. As a result of the analysis of the process of planning the public space structure and the factors influencing the effective transformation of post-industrial areas, the authors argue that the appropriate tool for the transformation of larger and integrated urban units of the city would be an equivalent of the former master plan. The basic content that should be included in such a plan is the functional and spatial structure, defining in particular the form and the layout of the city’s public space. The examples of master plans of Pelcowizna area in conjunction with the development plan analyzed in the text, in which hierarchical spatial structures have been distinguished, show the necessity to cover the entire urban unit with general guidelines and are an example of its more effective development. The article ends with a proposal of a method concerning the manner of constructing the city’s public space structure and being a condition for an effective transformation of post-industrial areas.
Advancement in recycling waste tire activated carbon to potential adsorbents
Authors: Ali Umi Fazara Md , Hussin Farihahusnah , Gopinath Subash C.B. , Aroua Mohamed Kheireddine , Khamidun Mohd Hairul , Jusoh Norwahyu , Ibrahim Naimah , Ahmad Syahirah Faraheen Kabir
Published: December 2021

Waste tires have been identified as one of the contributors to environmental problems and the issue of inadequate landfill spaces. The lack of consistent and systematic approaches such as specific regulations/laws or mechanisms of waste management to waste tires, limited application of technology for recycling waste tires and lack of awareness on the impacts of waste tires problem, make waste tires a source of environmental pollution. Various researches have been conducted on recycling waste tires into polymer bends, and materials to harden concretes, fuels and adsorbent. Researchers suggested that pyrolysis is the current trend of recycling waste tire to harvest the saleable pyrolysis oil and the recycled carbon black. Therefore, this review attempts to compile relevant knowledge about the potential of adsorbent derived from waste tires to be applied in the removal of various types of pollutants like heavy metals, organic pollutants, dye and air/gaseous pollutant. Studies were carried out on revealing the properties and the characteristics of activated carbon derived from waste tire as effective adsorbent which influence the application performance at liquid or gas phase. In addition, the challenges in the production of activated carbon derived from waste tire were discussed.
Managing Heritage Tourism Brand in South Africa: A Synthesis of Literature
Authors: Gumede Thembinkosi , Ezeuduji Ikechukwu
Published: December 2021

This paper aims to explore how branding essentials can foster or derail heritage tourism growth. Brand management capabilities support heritage tourism destinations such as South Africa to achieve competitive advantage in the global tourism marketplace. Heritage tourism destinations in Africa operate within a highly competitive environment as most of them offer identical products and services to their clientele. Unique historical and political backgrounds associated with particular geographical regions foster their heritage tourism growth. Subsequently, in South Africa, different forms of tourism that exist within the heritage tourism niche such as cultural tourism have gained immense popularity as they attract numerous domestic and international tourists to heritage tourism sites. Branding as a composite of numerous essentials including, but not confined to, brand essence, brand image and brand loyalty, is believed to be a key factor that can either stimulate or hinder heritage tourism growth in tourist destinations including South Africa. A conceptual model has been developed in this paper, based on the interlinkages between the key essentials of destination branding and how they influence heritage tourism growth. This paper posits that there is a strong relationship and interrelatedness between destination branding and heritage tourism growth.
The Effect of Green Human Resource Management on Green Organizational Behaviors: Evidence from Egyptian Travel Agencies
Authors: Gaafar Hebatallah Ali , Elzek Yelha , Al-Romeedy Bassam Samir
Published: December 2021

The main aims of this study were to measure the influence of GHRM on green organizational behaviors (green employee empowerment, environmental organizational citizenship behavior, employee voice behavior, and environmental performance), and investigate the mediating role of the variables in the effect of GHRM on green organizational behaviors. We developed and tested a model that involves the effect of GHRM on green organizational behaviors and investigates their correlation to environmental performance. Data were gathered from 653 employees working in travel agencies in Egypt. Results revealed that GHRM is positively affected green organizational behaviors. It was concluded that the application of GHRM practices in Egyptian travel agencies is lacking, and the level of implementing green behaviors is in its infancy. The study contributes to providing a road map to adopt GHRM in travel agencies. Policy-makers need to modify their strategies to integrate green practices and encourage employees to act pro-environment, as well as motivate them to participate in making green decisions.
Tourism Demand Modelling and Forecasting: A Review of Literature
Authors: Abdou Musonera , Musabanganji Edouard , Musahara Herman
Published: December 2021

This research examines 145 key papers from 1979 to 2020 in order to gain a better sense of how tourism demand forecasting techniques have changed over time. The three types of forecasting models are econometric, time series, and artificial intelligence (AI) models. Econometric and time series models that were already popular in 2005 maintained their popularity, and were increasingly used as benchmark models for forecasting performance assessment and comparison with new models. In the last decade, AI models have advanced at an incredible rate, with hybrid AI models emerging as a new trend. In addition, some new developments in the three categories of models, such as mixed frequency, spatial regression, and combination and hybrid models have been introduced. The main conclusions drawn from historical comparisons forecasting methods are that forecasting models have become more diverse, that these models have been merged, and that forecasting accuracy has improved. Given the complexities of predicting tourism demand, there is no single approach that works well in all circumstances, and forecasting techniques are still evolving.
Ingeniería de los materiales y nanociencias
Authors: Morales-Paredes Carlos Augusto , García-Mujica Roberth Daniel , Morales-Paredes Edwin Fernando
Published: December 2021

La ingeniería de materiales es una rama de la ingeniería que diseña o proyecta la estructura de los materiales para obtener un conjunto de atributos predeterminados basados en la relación atributo-estructura. La ingeniería de materiales encuentra vinculada con la fabricación de materiales. El propósito de la nanociencia y la nanotecnología en el contexto de la ingeniería de los materiales radica en desarrollar e implementar materiales, herramientas o equipos que puedan ajustar el tamaño nanométrico e incluso molecular de los materiales.

Palabras claves: ingeniería, materiales, nanociencia, nanotecnología.
Agroecología y negocios locales: una revisión al panorama actual
Authors: Puente-Padilla Gabriela , Ponce-Álvarez Jimmy , Silva-Gorozabel Jhon Jairo
Published: December 2021

En los últimos años, un número significativo de entidades y empresas, en diferentes países y a nivel global, comenzaron a utilizar la tentativa de Agroecología, en un proceso que llevó a la misma hacia una expansión de múltiples significados, a medida que la agroecología se ha convertido en una tentativa a nivel global, al integrar aspectos y áreas fundamentales para su desarrollo como la ciencia, los movimientos sociales y la práctica, la necesidad aumentado las formas de evaluar el impacto fidedigno de la agroecología en el contexto de la sostenibilidad de la creación de los sistemas alimentarios, y específicamente en la creación de empresas basadas en la agroecología.

Palabras claves: Agroecología, ciencia, negocios locales.
CONGENITAL PHIMOSIS IN DOG: CASE REPORT
Authors:   Ingá University Centre – Uningá, Maringá, PR, Brazil., Parra Juliana de Carvalho , Gallo Guilherme Camargo ,   Ingá University Centre – Uningá, Maringá, PR, Brazil., Leal Leonardo Martins ,   Ingá University Centre – Uningá, Maringá, PR, Brazil.
Published: December 2021

Phimosis is a rare condition in dogs, characterized by the inability to externalize the penis from inside the foreskin, resulting in discomfort for the affected animals. This disease can be congenital or acquired, secondary to inflammatory, neoplastic, lacerations and scarring. The most common complication of phimosis is balanoposthitis. The objective was to report the case of phimosis in a canine puppy, seen at the veterinary clinic Uningá. The 2-month-old dog, SRD, presented an increase in foreskin volume, polyuria, dysuria and pain in the manipulation of the foreskin. There were no changes in hematological tests. The animal in question was submitted to an ultrasound examination to rule out other possible causes of phimosis, such as neoplasms, for example. The patient was referred for a postioplasty and elective orchiectomy procedure. We conclude that phimosis in dogs is a rare condition, but it has a good prognosis in the short and medium terms, as long as the surgical intervention is performed correctly.
Simple and cheap photosystem for herbarium digitization
Authors: Novikov Andriy , Sup-Novikova Mariia
Published: December 2021

The digitization of the natural history collections is a crucial task of today. It allows not only sharing the data but also virtually preserving the specimens. This is especially important for small collections that suffer from limited financial support and can be easily lost.

Here we share our experience of the building of cheap and simple photosystem that can be used for routine digitization of local herbaria with low or without incomes. This photosystem is modular and based on the regular components that can be easily purchased and/or updated. It is compact and can be conveniently assembled and disassembled, and transported. This photosystem consists of horizontal tripod Beike Q999H with two led lamps Yongnuo YN-300 Air mounted on the 11” Magic Arm handles. The camera Canon EOS 800D was chosen due to presence of fully rotated display, the high resolution, modern focusing system, RAW format support, and low price on the market. The lens Tokina AT-X M35 PRO DX AF 35 mm f/2.8 Macro was chosen due to extreme sharpness along the whole capturing field, low aberrations and optical distortion, high light sensitivity, and fast autofocus.

We also tested light box as an option for herbarium specimens’ digitization. However, we found that light box is inconvenient for herbarium digitization dues several reasons, among which its massive sizes, limited access to working space, and necessity of application of huge mounting system that should hold the camera far higher over the center of light box. In general, work with light box significantly decelerated the digitization process. We did not find any advantaged in use of the light box and therefore it was rejected. We hope that our experience will be useful for other curators wanting to digitize their collections and having limited budget.
Epistemología y posmodernismo. Los errores categoriales en Foucault y Vattimo
Authors: Cáceres Bejarano Héctor
Published: December 2021

Epistemológicamente, el pensamiento posmoderno se caracteriza por sustentarse en el subjetivismo y en un determinismo sociológico, político o cultural.  Este acusa los excesos del racionalismo y se aborda la realidad desde los sentidos y las experiencias personales, las emociones y sentimientos. Se pone de relieve la satisfacción personal y el hedonismo, apelando también a la libertad dentro del derecho y la democracia para establecer las opiniones o sentidos personales como formas válidas de conocimiento; incurriendo de esta en forma en algunos errores categoriales o falacias argumentales en el análisis de las ideas y hechos. Este artículo presenta y confronta diferentes expresiones del pensamiento posmoderno postulados por algunos de sus principales representantes. Entre ellos tenemos a G. Vattimo quien exhibe su visión filosófica y critica de la ciencia y la verdad; y por otra parte presentamos a M. Foucault con sus análisis críticos posmodernos de los discursos y el poder.
Organization of an obstetrics unit during the COVID-19 pandemic: a short literature review
Authors: Zanardini C. , Papaccio M. , Castellani R. , Orabona R. , Fratelli N. , Fichera A. , Franceschetti L. , Ferrari F. , Odicino F. E. , Sartori E. , Prefiimo F.
Published: December 2021

The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges for the delivery of high-quality obstetric services to both SARS-CoV-2 positive and negative women. The initial epidemiological pressure, especially in the most affected areas of China and Italy, led the local health services to defining care pathways based on the organizational and logistical availability of the moment. Currently, some aspects of clinical care practices and the management of women with suspected or confirmed SARS-CoV-2 virus infection are well established. The aim of this review article is to provide an outline of the suggested organization of obstetric units during the COVID-19 pandemic, and to mention the challenges we had to face at our institution.
Professional ethics of recommendations: implications for COVID-19 vaccination of women who are pregnant or planning to become pregnant
Authors: Chervenak F. A. , McCullough L. B. , Grunebaum A.
Published: December 2021

There has been changing guidance from national and international professional associations, national and international non-governmental organizations, and health officials in national governments for obstetrician-gynecologists about COVID-19 vaccination of pregnant women and women who are planning to become pregnant. in this paper, we provide an ethical framework that provides the needed guidance to decision making about recommending COVID-19 vaccination to these patients. the unique feature of this ethical framework is that it is based on professional ethics in obstetrics and gynecology. We begin with an account of three key components of professional ethics in obstetrics and gynecology and how they are pertinent to the ethics of making recommendations that should be understood in obstetric and gynecologic practice generally. We then identify the implications of this overview for the specific topic of the ethics of recommending COVID-19 vaccination.
Kamu Çalışanlarının Yaşam Memnuniyeti Düzeyinin Göç Etme Niyeti Üzerine Etkisi: Tortum İlçesi Örneği
Authors: KÜÇÜKALİ Adnan , BAKAN ATASEVER Sibel
Published: December 2021

Göç olgusu, insanlığın en eski tarihlerinden bu yana devam eden ve gelecekte de devam edecek olan dünyanın her yerinde görülebilecek bir durumdur. İnsanlar tarih içerisinde farklı nedenlerden dolayı yaşadığı mekândan ayrılmak durumuyla karşı karşıya kalmıştır. Göç kavramıyla ifade edilen günümüzde yaşam kalitesini arttırmak için bulundukları mekânlardan farklı mekânlara göç etme niyeti taşımaktadır. Bu çalışma kamu çalışanlarının yaşam memnuniyeti düzeylerinin göç etme niyeti üzerine olan etkisini tespit etmek amacıyla yapılmıştır. Erzurum ili Tortum ilçesinde görev yapan kamu çalışanları üzerinde bir araştırma yapılmıştır. Araştırma kapsamında 136 kamu çalışanına ulaşılarak yaşam memnuniyeti düzeyinin göç etme niyeti üzerine olan etkisini tespit etmek için anket çalışması uygulanmıştır. Toplanan veriler analiz edilerek yaşam memnuniyeti düzeyinin artmasının göç etme niyeti üzerine negatif yönde etki ettiği sonucuna ulaşılmıştır. Göç etme niyetinin oluşumunda sosyal çevrenin kısıtlılığı, bölgenin sosyo-ekonomik düzeyinin düşüklüğü, sosyal, kültürel ve sanatsal etkinliklerin yetersizlikleri belirleyici olmaktadır.
Implementation of Full Day School in Basic Schools in Forming Student’s Character
Authors:   Faculty of Teacher Training and Education, Universitas Lampung, Indonesia, Retnosari Asti
Published: December 2021

The importance of implementing full day school in character building in elementary school students makes the writer interested in making a literature review. Character education is important to be developed and internalized immediately, because it has a noble enough purpose for the provision of students’ lives so that they are always ready to respond to all the dynamics of life with full responsibility. The research method used is literature study. The purpose of this literature review is to obtain a theoretical basis that can support problem solving regarding the application of full day school in character building for elementary school students. The results of this research shows that full day school gives positive impact for the children’s growth especially on establishing the character values since the early stage started from the elementary school.
Exploring The Critical Factors Influencing the Using eLearning During the Covid-19 Pandemic: Case Study in Aljafara University Libya
Authors:   Aljafara University, College of Science and Natural Resources, Computer Department, Dihoum Basma Emhamed
Published: December 2021

Many institutions have been shut down and many economic, social, and educational activities have been disrupted by the spread of the coronavirus. Some universities and other educational institutions have opted for eLearning instead of traditional education techniques in order to keep the educational process moving. For the sake of students and teachers, several educational organizations have made their ePlatforms and libraries available for free. However, eLearning approaches have their own set of challenges and constraints that must be overcome to minimize their negative impacts. The purpose of this study is to identify the most significant problems that university instructors face when using eLearning. Teachers' views on eLearning in Libya are examined in this study, as well as their level of satisfaction and willingness to use the platforms. Many university professors were surveyed by e-mail to assess the most pressing issues they faced during the university's closure due to the development of the Corona epidemic. Instructors from two groups of academic workers who make up the sample: computer science department and mathematics department of Aljafara University are included in the study. SPSS software was used to conduct statistical analysis of the data. With a materiality of 71.8% and a mean of 3.62, the data reveal that the challenge of the instructors had the biggest impact. Third place went to all issues relating to students, and social issues came in second place. Materiality of 61% and a mean of 3.07 for accessibility were the next two factors that had the least impact on the eLearning process.
OPTIMASI KONSENTRASI NA-CMC SEBAGAI VISCOSITY MODIFIER TERHADAP SIFAT FISIK PASTA GIGI EKSTRAK DAUN KERSEN (Muntingia calabura L.)
Authors:   Sekolah Tinggi Teknologi Industri dan Farmasi Bogor, Kendi Tampoliu M. Kenli , Dewi Astuti Ratnaningsih ,   Politeknik Kesehatan Kementerian Kesehatan Palembang, Sinulingga Sadakata ,   Universitas Sriwijaya
Published: December 2021

Daun kersen (Muntingia calabura L.) mempunyai sifat antibakteri dengan cara menghambat aktivitas glukosiltransferase pada bakteri Streptococcus mutans. Pengembangan daun kersen menjadi sediaan pasta gigi dianggap perlu sehingga penggunaannya lebih efesien dan maksimal. Penelitian ini memiliki tujuan agar dapat memformulasikan ekstrak kental daun kersen sebagai sediaan pasta gigi yang memiliki sifat fisik yang baik. Penelitian ini menggunakan metode penelitian eksperimental. Ekstraksi daun kersen dilakukan dengan teknik maserasi menggunakan pelarut etanol 96% lalu dilakukan destilasi vakum sehingga menghasilkan ekstrak yang kental dari daun kersen. Kemudian ekstrak diformulasikan dalam sediaan pasta gigi sebesar 33% yaitu formula I, II dan III dengan variasi viscosity modifier Na CMC 3,0%, 3,5% dan 4,0%. Selanjutnya dilakukan uji sifat fisik selama penyimpanan selama empat minggu meliputi viskositas, pH, homogenitas, tinggi busa, bau, warna dan rasa. Berdasarkan hasil ekstrak yang didapat, diperoleh rendemen sebesar 7,36%. Hasil viskositas formula I berkisar 95055-116762 cp, formula II berkisar 121894-129891 cp dan formula III 128771-137552 cp. Berdasarkan hasil tersebut viskositas formula mengalami peningkatan selama penyimpanan. Pengukuran tinggi busa formula I berkisar 17-20 mm, formula II berkisar 17-18 mm dan formula III berkisar 17-19 mm. Didapatkan tinggi busa formula mengalami penurunan selama penyimpanan. Ditinjau dari uji viskositas, pH, homogenitas, tinggi busa, bau, warna dan rasa ketiga formula menunjukkan hasil memenuhi syarat selama penyimpanan. Dari penelitian ini dapat ditarik kesimpulan bahwa ekstrak daun kersen yang diformulasikan sebagai sediaan pasta gigi yang paling baik sifat fisiknya yaitu formula II dengan viscosity modifier Na CMC sebesar 3,5%.
Relationship marketing and the profile of the policewoman as an institutional image of the police service in Ecuador.
Authors: Gamboa Viera Maria Elizabeth , Espinoza Calle Jenny Carolina , Edwin Javier Santamaría Freire
Published: December 2021

The article shows how relationship marketing and the profile of policewomen affect the institutional image of the police service in Ecuador, for which a qualitative methodology is used with a descriptive and correlational level of research, based on a bibliographic and field study. Tools and techniques applied to the community and to policewomen are also used; whose results explain that there is better performance, generate greater confidence and security; in the self-criticism made by the police servants, they state that they feel capable of acting, working efficiently in all cases. Its preparation is daily so there is a commitment to serve and protect; her work is praised by the community, which makes the policewoman an excellent option to position the police image thatis currently worn out. These results were contrasted with the hypothesis test in which a Pearson X2 of 8,549 was obtained, which allows us to conclude that relationship marketing and the profile of the policewoman do contribute to the institutional image of the police service in Ecuador.
Keywords: marketing, relationship marketing, policewoman, institutional image.
References
[1]P. Tobar, «Marketing de relaciones como estrategia de diferenciación en la satisfacción del cliente: caso de estudio en el sector universitario,» Digital Publisher, 3 Mayo 2021.
[2]M. Luna and R. Ortiz, «Aplicación del Marketing relacional para fidelización de clientes corporativos en servicio de telefonía móvil CNT EP.,» Universidad deGuayaquil, 2018.
[3]M. Rivera, «La evolución de estrategoas de marketing en el entorno digital: Implicaciones jurídicas,» Universidad Carlos III de MAdrid, 2015.
[4]L. Sihua, «Imagen corporativa y marketing relacional de la empresa Pieriplast SAC, distrito San Juan de Lurigancho, 2018,» Unversidad Cesar Vallejo, 2019.
[5]E. Guadarrama and E. Rosales, «Marketing relacional: Valor, satisfacción, lealtad y retención del cliente. Análisis y reflexión teórica,» Ciencia y Sociedad, 2015.
[6]M. Noblecilla and M. Granados, «El marketing y su aplicación en diferentes areas del conocimiento,» Editorial UTMach, 2017.
[7]R. Bravo, J. Matute and J. M. Pina, «Efectos de la imagen corporativa en el comportamiento del consumidor. Un estudio aplicado a la banca comercial,» vol. 21, 2021.
[8]J. Saltos, W. Jiménez and E. Jimémex, «La imagen de marca como vector de posicionamiento en PYMES: caso sector calzado de la provincia de Tungurahua,»2016.
[9]E. Ramos, «Gestión de imagen corporativa como estrategia de sostenibilidad: camino al cambio empresarial, » Revista Universidad y Sociedad, 2020.
[10]A. Sevilla, «Policia Comunitaria,» Programa para la convivencia ciudadana, 2015.
[11]E. Cobler, «El trabajo de la mujer policía,» Revista Catalana De Seguretat Pública, p. 106, 2012.
[12]E. Cumbicos, «Imagen Institucional De La Policía Metropolitana De Quito En Redes Sociales,» Universidad Central del Ecuador, 2017.
Perencanaan dan Strategi Pemasaran Asuransi
Authors: Dalimunthe Mei Habibah , Aslami Nuri
Published: December 2021

The purpose of this article is to find the marketing plans and strategies that a company needs to develop its business. Because, as we know, the challenges for the Indonesian insurance industry are increasing with the number of foreign insurance companies, which is a direct result of globalization. In the next era, called globalization, Indonesian insurance / reinsurance companies will work to develop their insurance business with the "invasion" of foreign insurance / reinsurance companies with strong capital, reliable technology and human resources. Must be. And reinsurance in other countries.

Keywords: Marketing Planning, Marketing Strategy, Syariah Insurance
Strategi Pemasaran Agen PT Prudential Dalam Mmpertahankan Loyalitas Nasabah Prulink Syariah
Authors: Putri Indri Anggraini , Aslami Nuri
Published: December 2021

This review expects to investigate the advertising procedure of PT Prudential's representatives in keeping up with the devotion of prulink sharia clients. This examination technique utilizes engaging subjective strategy with information investigation, in particular information assortment, interviews, information show and end drawing. The consequences of the review propose that in keeping up with client unwaveringness the advertising techniques of PT Prudential's representatives are right off the bat by giving intermittent data to clients, besides assembling individual associations with clients. Considering that there are as yet many individuals who don't comprehend the significance of protection, it is a chance for advertisers to give protection instruction to the public so they can grow the sharia protection business.

 Watchwords: methodology, client devotion, specialist.
Z_2^r×Z_2^s×R^t Halkası Üzerindeki Devirli Kodlar İçin Bazı Sonuçlar
Authors: BALIKÇI Kemal
Published: December 2021

Z_4 halkası kodlama teorisinde çok önemli bir yere sahip olmasına rağmen, dört elemanlı önemli diğer bir halka Z_2 [u] halkasıdır. Z_2 [u] halkası üzerindeki lineer ve devirli kodların Z_4 halkası üzerindeki lineer ve devirli kodlara göre bazı avantajları olduğu iyi bilinmektedir. Bu çalışmada, ilk olarak 〖Z_2 Z〗_2 Z_2 [u]-lineer kodlar ve devirli kodlar tanımlandı. Daha sonra, Z_2^r×Z_2^s×R^t’deki Lee uzaklığını Z_2^n’deki Hamming uzaklığına dönüştüren Gray dönüşümü kullanılarak 〖Z_2 Z〗_2 Z_2 [u]-lineer kodların Gray görüntüleri elde edildi. Ayrıca, 〖Z_2 Z〗_2 Z_2 [u]-lineer kodların standart üreteç ve kontrol matrislerinin formu belirlendi. Böylece bir 〖Z_2 Z〗_2 Z_2 [u]-lineer kodun tipi ve sahip olduğu kodsöz sayısı verildi. Dahası, 〖Z_2 Z〗_2 Z_2 [u]-devirli kodların cebirsel yapıları incelendi ve bu kodların üreteç polinomları ile minimum üreteç kümeleri belirlendi. Son olarak, ayrılabilir 〖Z_2 Z〗_2 Z_2 [u]-devirli kodların duallerinin formu araştırıldı ve etkili bazı örnekler verildi.
PENGARUH PENAMBAHAN SERAT IJUK PADA PAVING BLOCK BERBAHAN PLASTIK HDPE
Authors: Hutauruk Denny Meisandy , Irwansyah Muhammad , Alfa Akbar
Published: December 2021

The waste problem continues to be a complex issue. On the one hand, the use of plastic still cannot be abandoned by humans, but on the other hand the waste produced is very difficult to decompose. In Indonesia, in 2015 the amount of waste reached 64 million tons / year. Palm fiber is one of the materials that can be used as composite fiber. In this study, a research will be conducted on the manufacture of paving blocks made from HDPE plastic combined with variations of 0%, 1%, 2% and 3% palm fiber. Plastic waste is melted and put into a mold and then combined with palm fiber. From the test results, the highest compressive strength (2% fiber variation) was 45.91 kg/cm2 and the average compressive strength was 45.28 kg/cm2. This compressive strength is under the minimum compressive strength standard of SNI

 

Permasalahan sampah masih terus menjadi isu kompleks. Di satu sisi, penggunaan plastik masih belum bisa ditinggalkan manusia, namun di sisi lain sampah yang dihasilkan sangat sulit terurai. Di indonesia, pada tahun 2015 tercatat banyaknya sampah mencapai 64 juta ton/tahun. Ijuk merupakan salah satu material yang dapat digunakan sebagai serat komposit. Pda penelitian ini akan dilakukan penelitian mengenai pembuatan paving block berbahan dasar plastik HDPE yang dikombinasikan dengan variasi serat ijuk 0%, 1%, 2 % dan 3%. Limbah plastik dilelehkan dan dimasukkan ke dalam cetakan lalu dipadukan dengan serat ijuk. Dari hasil pengujian, didapatkan kuat tekan tertinggi (variasi serat 2%) sebesar 45,91 kg/cm2 dan kuat tekan rata-ratanya sebesar 45,28 kg/cm2. Kuat tekan ini berada di bawah standar kuat tekan minimal dari SNI.
Bioinformatics Storing Databases
Authors: Abed Raghad , Al-Najjar Yusra
Published: December 2021

An exceptional branch of data that requires huge databases has been shown lately from genome sequencing projects which is a field that employs computational approaches to answer biological questions. With this huge sequence of information that is available for researchers, bioinformatics plays a big role in studying basic medical-biological problems. The challenge that faces bioinformatical scientists is to help in discovering genes and designing molecular models, site-directed mutagenesis, and other experiments that reveal the unknown relationships concerning the structure and function of genes and proteins. This become a big challenge especially with the huge amount of data that is generated using the human genome and other systematic sequencing efforts up till now. Bioinformatics solves biological problems depending on available data. It is concerned with creating databases and predicting the outcome of lab experiments.
What Happened Between Beycesultan XIII and XII? New Answers from Laodikeia-Kandilkırı Early Bronze Age Levels
Authors: OĞUZHANOĞLU Umay
Published: December 2021

Beycesultan has provided the longest chronological sequence in southwest Anatolia for the Bronze Age. There J. Mellaart noticed a change in the material culture at level XIII and called it a “complete break in the culture.” He claimed that the fire and destruction at this level was the result of the migration of Indo-Europeans to the region Some scholars suggest that there is a chronological gap in Beycesultan between levels XIII and XII, which is the cause of this so-called break. Recently pottery seriation and absolute dating obtained by the excavations at Laodikeia-Kandilkırı in Denizli province yielded enough evidence to prove that there was neither a break in the material culture nor any sign of invasion in the Denizli region in Early Bronze Age 2 or 3A. Instead, there existed a moderate period of change in the Denizli region due probably to the impact of the network of interregional connections in Anatolia’s EBA 3A during the chronological gap between Beycesultan levels XIII and XII. Kandilkırı was abandoned around 2200 BC, probably due to a climate crisis and the fall of the interregional connective network.
Rock-Cut Tombs and Two Lycian Inscriptions from Karabel-Çamdağı
Authors: İŞLER Bülent , TEKOĞLU Ş. Recai
Published: December 2021

A survey-based project on Byzantine settlements around Alacadağ in Lycia has continued since 2014. It has aimed to identify and document late antique and medieval rural settlements located in the northern mountainous area of Demre (Myra), a town in the province of Antalya. A group of building remains were found during our fieldwork in 2020. These remains are located at forested Eşekkırığı in the Karabel district situated 17 km north of the ancient city of Myra. Its ancient ruins are

scattered on the slopes and top of the hill to the southwest of the quarry located at the second kilometer of the dirt road from Karabel to Çamdağı. A small Byzantine castle sits at the top at an altitude of 1218 m. A tower and two workshops are located on the southern slope; three rock-cut tombs are on the eastern, western and northern slopes. This article aims to study the rock-cut tombs with their inscriptions. Two of the tombs bear inscriptions in the Lycian language. Both inscriptions can be

dated to the second half of the fourth century BC on the basis of paleographic evaluation.
Stamps of Hellenistic Imported Amphorae Found in the Excavations of Nicaea (Iznik) Theater
Authors: CANKARDEŞ-ŞENOL Gonca , EKİN-MERİÇ Aygün
Published: December 2021

During the recent excavations in the Roman Theater in Nicaea (Iznik), constructed under the reign of the Roman emperor Trajan between AD 98-117, numerous Hellenistic ceramics were found in the levels dated to the period before its construction. Among them, stamps belonging to imported amphorae have also been unearthed. Stamps of Greek and Latin amphorae indicate both the preference and demand of the inhabitants of Nicaea as well as shed preliminary information about the Hellenistic trade of the city. In this article, these amphora stamps, the trade relations of the production centers with the city and the region, and the ancient routes used for bringing goods into the city are discussed.
Abandonment, Continuity, Transformation: Setting Komana into Archaeological Context through the Middle Byzantine and Early Turkish Periods
Authors: TATBUL Mustafa Nuri
Published: December 2021

Historical sources indicate Turks came into Anatolia starting from the middle of the 11th century. This must have had critical short- and long-term impacts on various aspects of life in the region. Based on the archaeological evidence, it can be suggested that the settlement dynamics started to change during the period of confrontation between the Byzantines and Turks as a result of the shifting political authority on a regional scale. This article will try to identify changing settlement dynamics through the 11th-13th centuries at Komana and its territory with a comparison of other contemporary settlements in the inland Black Sea region and central Anatolia. Thus, archaeological data that shed light on our understanding of abandonment, continuity and transformation are discussed and categorized as indicators.
Relocating African Agency: Assessing the Role of ‘Local Patrons’ and Chinese Enterprises in the Construction Sector in Ghana
Authors: Alden Chris , Ocquaye Nathaniel
Published: December 2021

Contrary to the conventional notion that African agency outside of the state is marginal if not irrelevant, this paper argues that it is ‘local patrons’ in Africa who are actually the most powerful determinants of the success of Chinese enterprises in Africa. These ‘local patrons’ exact financial resources from the Chinese in exchange for their services as brokers between state officials. Specifically, their ‘informal connections’ to local state authorities enables them to insure the Chinese firms against official state prosecution/demands as well as facilitate related bureaucratic procedures. Using the case of the Chinese construction firms operating in Ghana, we will investigate the challenges experienced by Chinese firms entering into new markets and the strategies utilised by them to address and mitigate risk in their search for profit, chief amongst them the employment of ‘local patrons’ to serve as brokers with state officials. This relocation of agency, drawing from scholarship by Mohan, Lampert and Soule-Kohndou as well as the empirical materials based on substantive fieldwork, provides new insights into terms of engagement with local actors that form a bonded relationship facilitating integration of Chinese enterprises into the African political economy.
Regulation of Work Breaks in Hungary with a European Perspective
Authors: Román Róbert
Published: December 2021

The basis for the review of the Hungarian and European rules of the rest break during the working day was the fact that there was a lawsuit to establish the illegitimacy of termination, in which I represented the plaintiff. The reason for the summary dismissal on the part of the employer was that the employee was playing cards while on a rest break during the working day. In his action, the plaintiff sought a declaration that his employer had unlawfully terminated his employment. By the judgment of the Court of First Instance, the action was dismissed, and the plaintiff was ordered to bear the court costs. By the judgment of the Court of Law proceeding by the plaintiff’s appeal, the judgement was reversed, and it ordered the defendant to pay the plaintiff severance pay as well as compensation. The defendant presented an application for review, which was not upheld. After completing the matters of fact, the Court of Appeal correctly stated that, at the time of the inspection, the plaintiff availed himself of a rest break during the working day, which was lawful; moreover, it was not disputed by the defendant. The Court of Appeal rightly concluded that the employer may prohibit the employee from playing cards during breaks in the workplace, but this must be communicated unequivocally to him, and this expectation must be consequently carried out. The Court of Appeal also rightly pointed out that in the case of explicit prohibition of some behaviours, employees must also be informed of the legal consequences, which are applicable in case of infringement of the rule. However, in the present case, this was not established, so that the lawsuit ended with the full recovery of a favourable judgment of the employee plaintiff at the Supreme Court of Justice.
Gizli sınıf analizi ile Türkiye’de cinsiyet eşitsizliğine bakış açısının değerlendirilmesi
Authors: DEVECİ Enescan , YORULMAZ Özlem
Published: December 2021

Toplumsal hayatta kadın ve erkeklerin eğitim, çalışma hayatı ve çeşitli sosyal alanlarda eşit olarak görülmemesi bir sorun olarak karşımıza çıkmaktadır. Bireylerin cinsiyetleri nedeniyle maruz kaldıkları eşit olmayan tutum ve davranışların şekillenmesinde gelenek ve görenekler önemli rol oynar. Kadın ve erkeklerin toplumsal yaşamın her alanında eşit söz sahibi olmaları bir gelişmişlik göstergesi olan İnsani Gelişmişlik İndeksi’nin de bileşenlerinden birini oluşturur. Birçok ülke çeşitli politikalarla toplumsal cinsiyet eşitliğini desteklemektedir. Literatürde yer alan çeşitli çalışmalarda ekonomik büyüme ve cinsiyet eşitliğinin birbirini desteklediği görülmüştür. Cinsiyet eşitliği sadece toplumsal gelişim üzerinde etkili olmakla kalmayıp aynı zamanda kadınların yaşam kalitesi üzerinde de bir etkiye sahiptir. Bu çalışmada, bireylerin sosyo-ekonomik ve demografik özelliklerinin, politik görüşlerinin, demokrasiye olan inançlarının ve dindarlık düzeylerinin cinsiyet eşitsizliği kavramına bakış açıları üzerindeki etkileri değerlendirilmiştir. Dünya Değerler Anket verisinden hareketle Gizli Sınıf Analizi ile yapılan değerlendirmede toplumun cinsiyet eşitsizliği hakkındaki düşüncelerinin genel olarak iki farklı sınıfta incelenebileceğini sonucuna ulaşılmıştır. Bu sınıfların belirleyiciliği üzerinde etkili olan değişkenler eğitim düzeyi, cinsiyet, politik görüş ve demokrasiye olan inanç düzeyidir. Bununla birlikte yaşın, sosyal statünün ve dindarlık düzeyinin bu grupların belirlenmesinde önemli olmadığı görülmüştür.