bluuebunny/crossref_metadata_2025 huggingface dataset:
Stuck in the middle with you: Predictors of commitment in midlife
Authors: Johnson Matthew D. , Somerville Sarah D. , Galambos Nancy L. , Krahn Harvey J.
Published: November 2019

Rooted in commitment theory, this study examines dedication, perceived investments, and felt constraint, three unique aspects of commitment, in midlife using data gathered from a sample of 224 adults surveyed at ages 43 and 50 years. Positive and negative dimensions of couple relations (partner supportiveness and the extent to which one’s partner is demanding and critical, referred to as strain) assessed longitudinally and midlife-specific circumstances, including being in a first marriage or remarriage and parental and empty nest status, were examined as predictors of commitment at age 50. Latent change score modeling revealed partner support and strain as robust predictors of commitment. Higher levels of partner support at age 43 and a more gradual intraindividual decrease in support between ages 43 and 50 predicted higher dedication and perceived investments and less felt constraint at age 50. Higher age 43 levels of partner strain predicted more perceived investments and felt constraint at age 50, while a more rapid increase in strain predicted less dedication and more felt constraint. Being in a first or remarriage, being a parent, or having an empty nest did not predict commitment. These results highlight the importance of initial levels and changes in couple relations for shaping midlife commitment.
Fatherhood after Union Breakup in Uruguay: Transitory or Life-Long Commitment?
Authors: Pardo Ignacio , Martín-García Teresa , Castro-Martín Teresa , Cabella Wanda
Published: November 2019

Rising union dissolution in Latin America—and in much of the world—has increased public concern over the involvement of nonresidential fathers in the lives of their children. At the same time, social norms about post-separation fatherhood have changed, increasingly favoring not only economic support, but also participation in child-rearing. In this article, we (a) examine several dimensions of nonresidential fathers’ involvement with their children, (b) test whether there is a link between pre-separation and post-separation fathering practices, and (c) explore which dimension of pre-separation fathering practices—engagement, accessibility, and responsibility—is more influential on post-separation paternal behavior. The study is based on two waves of a longitudinal national survey carried out in Uruguay. Empirical findings suggest that fathers’ pre-separation involvement in child-rearing affects their post-separation parenting behavior, although results are not conclusive in all aspects of post-separation involvement, and father’s educational attainment tends to have a more influential role.
Geomorphology of the Anthropocene in Mediterranean urban areas
Authors: Brandolini Pierluigi , Cappadonia Chiara , Luberti Gian Marco , Donadio Carlo , Stamatopoulos Leonidas , Di Maggio Cipriano , Faccini Francesco , Stanislao Corrado , Vergari Francesca , Paliaga Guido , Agnesi Valerio , Alevizos Georgios , Del Monte Maurizio
Published: November 2019

Urban-geomorphology studies in historical cities provide a significant contribution towards the broad definition of the Anthropocene, perhaps even including its consideration as a new unit of geological time. Specific methodological approaches to recognize and map landforms in urban environments, where human-induced geomorphic processes have often overcome the natural ones, are proposed. This paper reports the results from, and comparison of, studies conducted in coastal historical cities facing the core of the Mediterranean Sea – that is, Genoa, Rome, Naples, Palermo (Italy) and Patras (Greece). Their settlements were facilitated by similar climatic and geographical contexts, with high grounds functional for defence, as well as by the availability of rocks useful as construction materials, which were excavated both in opencast and underground quarries. Over centuries, urbanization has also required the levelling of relief, which was performed by the excavation of heights, filling of depressions and by slope terracing. Consequently, highly modified hydrographic networks, whose streams were dammed, diverted, modified in a culvert or simply buried, characterize the selected cities. Their urban growth, which has been driven by maritime commercial activities, has determined anthropogenic coastal progradation through port and defence or waterfront works. Aggradation of artificial ground has also occurred as a consequence of repeated destruction because of both human and natural events, and subsequent reconstruction even over ruins, buried depressions and shallow cavities. As a result, the selected cities represent anthropogenic landscapes that have been predominately shaped by several human-driven processes, sometimes over centuries. Each landform represents the current result, often from multiple activities with opposing geomorphic effects. Beyond academic progress, we believe that detecting and mapping these landforms and processes should be compulsory, even in risk-assessment urban planning, because of the increase of both hazards and vulnerability as a result of climate-change-induced extreme events and extensive urbanization, respectively.
Whole blood platelet aggregation kinetics under cardiopulmonary bypass: A pilot study
Authors: Petzold Tobias , Bagaev Erik , Herzog Helen , Born Frank , Hoechter Dominik , Michel Sebastian , Rutkowski Simon , Lüsebrink Enzo , Thienel Manuela , Massberg Steffen , Hagl Christian , Guenther Sabina PW
Published: November 2019

Assessing the platelets’ functional status during surgery on cardiopulmonary bypass is challenging. This study used multiple electrode impedance aggregometry (Multiplate®) to create a timeline of platelet aggregation changes as induced by cardiopulmonary bypass in antiplatelet-naive patients undergoing elective surgery for mitral valve regurgitation. We performed six consecutive measurements (T1: pre-operatively, T2: after heparinization, T3: 3 min after establishment of cardiopulmonary bypass, T4: immediately after administration of cardioplegia, T5: 5 min after administration of cardioplegia, and T6: 45 min after administration of cardioplegia). Platelet aggregation was determined after stimulation with 3.2-μg/mL collagen, 6.4-μM adenosine diphosphate, and 32-μM thrombin receptor activating peptide. Five patients were included (age: 64 ± 10 years, one female). We observed a decrease in hematocrit levels by −17.1% ± 3.7% (T1 vs T6) with a drop after establishment of cardiopulmonary bypass (T2 vs T3) and slightly decreasing platelet counts by −6.2% ± 7.7% (T1 vs T6). Immediately after establishment of cardiopulmonary bypass (T2 vs T3), we observed reduced platelet aggregation responses for stimulation with adenosine diphosphate (−19.7% ± 12.8%) and thrombin receptor activating peptide (−19.3% ± 6.3%). Interestingly, we found augmented platelet aggregation for all stimuli 45 min after administration of cardioplegia (T5 vs T6) with the strongest increase for collagen (+83.4% ± 42.8%; adenosine diphosphate: +39.0% ± 37.2%; thrombin receptor activating peptide: +34.5% ± 18.5%). Thus, after an initial drop due to hemodilution upon establishment of cardiopulmonary bypass, platelet reactivity increased over time which was not outweighed by decreasing platelet counts due to mechanical platelet destruction and absorption. These findings have implications for rational transfusion, peri-operative antiplatelet therapy, and for the management of patients on other extracorporeal support, such as extracorporeal life support or extracorporeal membrane oxygenation.
Discovering One’s Own Way: Adolescent Girls’ Different Pathways Into and Out of Self-Harm
Authors: Stänicke Line Indrevoll , Haavind Hanne , Rø Frida Gullestad , Gullestad Siri Erika
Published: November 2019

Self-harm is associated with mental illness and suicide risk. The present study aims to increase knowledge of adolescent girls’ pathways into and out of self-harm. The participants were 19 girls, 13 to 18 years of age, who were strategically selected from an outpatient care unit. A naturalistic multiple case study was done with personal interviews. The interviews were analyzed using Interpretative Phenomenological Analysis, and the capacity for “mentalization”—representation of behavior in terms of mental states—was measured with the Reflective Functioning Scale. The analysis of the topic “beginning self-harm” resulted in two meta-themes: (a) beginning self-harm as a way to handle difficult feelings and relational problems and (b) becoming influenced by peers to experiment with self-harm. The analysis of the topic “quitting self-harm” resulted in three meta-themes: (a) ambivalence toward help, treatment, and ending self-harm; (b) finding one’s own way of quitting self-harm; and (c) exploring self-harm together with the therapist. Three case stories illustrate variations in trajectories of change and capacity for mentalization. The findings suggest that self-harm may be a way of handling developmental challenges in autonomy and identity formation during adolescence. Adolescents need an opportunity to discover their own way of quitting self-harm. Variations in mentalization may provide for different pathways.
Effects of thermal–oxidative aging on the mechanical properties of open-hole T800 carbon fiber/high-temperature epoxy composites
Authors: Xu Liang , He Yi , Jia Yaoxiong , Ma Shaohua , Hui Li
Published: November 2019

T800 carbon fiber/high-temperature epoxy resin composites with holes were subjected to thermal–oxidative aging, and the effects of different aging temperatures and times on the composite properties were investigated. The mass loss, surface topography, open-hole tensile performance, fracture morphologies, dynamic mechanical properties, and infrared spectra were analyzed. The results showed that chemical aging did not occur with thermal–oxidative aging at 70°C and 130°C. However, chemical aging occurred at 190°C. At 70°C, 130°C, and 190°C, all samples showed a slight increase followed by a slight decrease and stabilization in the open-hole tensile strength. The open-hole tensile strength was maximized after 240 h aging at different temperatures; the open-hole tensile strength after 1920 h aging exceeded that of the unaged samples. All composites experienced through-hole failure. With aging, the glass transition temperature ( T g) was gradually increased and then decreased. After 960 h aging at different temperatures, T g was maximized.
Volunteer satisfaction in sports clubs: A multilevel analysis in 10 European countries
Authors: Nagel Siegfried , Seippel Ørnulf , Breuer Christoph , Feiler Svenja , Elmose-Østerlund Karsten , Llopis-Goig Ramon , Nichols Geoff , Perényi Szilvia , Piątkowska Monika , Scheerder Jeroen
Published: November 2019

Regular voluntary engagement is a basic resource for sports clubs that may also promote social cohesion and active citizenship. The satisfaction of volunteers is an imperative factor in this engagement, and the purpose of this article is to explore individual and organizational determinants of volunteer satisfaction in sports clubs. Theoretically, our study builds on the actor-theory concepts where volunteer satisfaction depends on subjective evaluations of expectations and experiences in a sports club (‘logic of situation’), so that positive evaluations lead to higher satisfaction and, hopefully, retention of volunteers. This research uses a sample of 8131 volunteers from 642 sports clubs in 10 European countries, and is the first analysis to combine determinants at the level of the club and the volunteer (multilevel). Results show that the most important determinants of satisfaction are the conditions of volunteering (recognition, support, leadership and material incentives) and the workload of volunteers. Surprisingly, club characteristics, size or having paid staff are not significant determinants of volunteer satisfaction. The results of this analysis can assist more effective volunteer management in sports clubs that are facing challenges of individualization and professionalization.
The Empowering Leadership Project
Authors: Webber Sheila Simsarian , O’Neill Regina M. , Dossinger Karyn
Published: November 2019

The Empowering Leadership Project was developed by the authors to improve management students’ practice and understanding of empowering leadership, an emerging theory for leadership in the team context that includes Power Sharing, Motivation Support, and Development Support. In the project, student teams select a short leadership challenge, developed from the authors’ consulting work with mid-level team leaders, that exemplifies one of the key aspects of empowering leadership. The teams conduct research on the leadership challenge, analyze research, and prepare proposed solutions and implementation plans to solve the leadership challenge. Instructions for the Empowering Leadership Project are provided as well as students’ reactions to the project.
Risankizumab for the Treatment of Moderate to Severe Plaque Psoriasis
Authors: Li Wendy , Ghamrawi Rima , Haidari Wasim , Feldman Steven R.
Published: November 2019

Objective: Risankizumab (Skyrizi), an interleukin-23 (IL-23) antagonist, was approved by the Food and Drug Administration (FDA) for the treatment of moderate to severe plaque psoriasis in April 2019. This article will review phase II and III clinical trials to assess the efficacy, safety, and clinical application of this drug. Data Sources: A systematic literature review was performed using the terms “psoriasis AND risankizumab” in the OVID MEDLINE, PubMed, Cochrane Library, EMBASE, and Web of Science databases. ClinicalTrials.gov was searched to identify ongoing or nonpublished studies. Study Selection and Data Extraction: Articles written in English between January 2000 and October 2019 discussing phase II and phase III clinical trials were evaluated. Data Synthesis: By the primary end point at week 16 in phase III trials, more patients achieved Psoriasis Area and Severity Index 90 receiving 150 mg risankizumab (72%-75%) compared with placebo (2.0%-4.9%, P < 0.001), 45 or 90 mg ustekinumab (42.0%-48%, P < 0.0001), and 40 mg adalimumab (47%, P < 0.0001). More patients achieved a static Physician’s Global Assessment score of 0 or 1 receiving 150 mg risankizumab (84%-88%) compared with placebo (5.1%-7.8%, P < 0.001), 45 or 90 mg ustekinumab (62%-63%, P < 0.0001), and 40 mg adalimumab (60%, P < 0.0001). Risankizumab was well tolerated across all studies. Conclusion: Risankizumab is a newly FDA-approved IL-23 inhibitor that shows particular promise in the treatment of plaque psoriasis. Based on this review, it is an effective and safe addition to the armamentarium of biologics that are currently available.
Radiologic Evaluation of the Effect of Distal Tibiofibular Joint Anatomy on Arthroscopically Proven Ankle Instability
Authors: Ataoğlu Muhammet Baybars , Tokgöz Mehmet Ali , Köktürk Anıl , Ergişi Yılmaz , Hatipoğlu Mustafa Yasin , Kanatlı Ulunay
Published: November 2019

Background:

Ankle sprains occur frequently in both athletes and the general population. The social and economic consequences can be significant. In an effort to understand the injury, dynamic and static structures around the ankle have been investigated in detail, but anatomical factors predisposing to lateral ankle instability have not been fully clarified. The aim of this study was to radiologically investigate the relationship between bony variations of the distal tibiofibular joint and arthroscopically proven ankle instability.

Methods:

Fifty patients with arthroscopically proven ankle instability and 50 patients without instability were included in this study. Measurements were obtained from a magnetic resonance imaging (MRI) section 1 cm proximal to the tibiotalar joint; distal tibiofibular joint anterior facet length ( a), posterior facet length ( b), angle between the anterior and posterior facets ( c), fibular notch depth ( d), tibia thickness ( e), and fibula thickness ( f) was measured.

Results:

It was found that instability was more frequent when the length of a ( P < .001) and e ( P < .001) were shorter. In addition, when value of a/ b and e/f were evaluated, it was observed that the number of individuals who had instability increased as the ratio became smaller ( P < .016-.020, respectively). Pearson correlation analysis indicated strong negative correlation between the values of a- e and instability ( r = −0.348, P < .001, and r = −0.328, P = .001; respectively).

Conclusion:

Lateral ankle sprains are common, and a clear understanding of the relevant structures and clinical function of the ankle complex should extend beyond the talocrural joint. This study demonstrated that the presence of narrow anterior facet ( a) and thinner tibia ( e) were strongly correlated with lateral ankle instability.

Level of Evidence:

Level III, retrospective case control study.
Organizational Ethnic Diversity’s Influence on Hotel Employees’ Satisfaction, Commitment, and Turnover Intention: Gender’s Moderating Role
Authors: Hsiao Aaron , Ma Emily (Jintao) , Lloyd Kathleen , Reid Sacha
Published: November 2019

The aim of this study was to explore whether Taiwanese hospitality workers’ gender moderates the relationship between perceived ethnic diversity levels within their workplace and work-related outcomes at an individual employee level. Data were collected from 371 employees across 26 hotels in Taiwan. The results supported mediation effects of job satisfaction and affective commitment on the relationship between perceived ethnic diversity and employees’ turnover intention. Gender moderated the relationships between perceived diversity and job satisfaction, affective commitment and the relationships between job satisfaction and turnover intention. This study highlights the importance of ethnic diversity impacts on employee work outcomes within Asian hospitality organizations, specifically in Taiwan.
Playing the Game: A Qualitative Exploration of the Female Experience in a Hypermasculine Policing Environment
Authors: Brown Timothy C. , Baldwin Julie M. , Dierenfeldt Rick , McCain Steven
Published: November 2019

Domestically and globally females continue to be underrepresented in policing, despite their greater likelihood of advancing themselves through higher education, driving organizational change, and being less likely to use excessive force or be named in civil litigation than their male counterparts. Extant research indicates that women may be effectively gated from policing by a subculture that aggrandizes characteristics consistent with the crime-fighting paradigm. Using qualitative data from in-depth interviews with female officers, this study investigates the female officer experience of police subculture in terms of masculinity, gender disparities, and sexualized activities. To understand the perceived environment of the department and contextualize it within the literature, the dominance of masculine personality traits and gender disparities within the department are first explored to determine whether a hypermasculine subculture was present. Then, female officers’ definitions of sexual harassment, their roles in these activities, and their motivations for participation were examined.
PICC-PORT totally implantable vascular access device in breast cancer patients undergoing chemotherapy
Authors: Bertoglio Sergio , Cafiero Ferdinando , Meszaros Paolo , Varaldo Emanuela , Blondeaux Eva , Molinelli Chiara , Minuto Michele
Published: November 2019

Background and objectives:

The increasing use of arm totally implantable vascular access devices for breast cancer patients who require chemotherapy has led to a greater risk of complications and failures and, in particular, to upper extremity deep vein thrombosis. This study aims to investigate the outcomes of the arm peripherally inserted central catheter-PORT technique in breast cancer patients.

Methods:

The peripherally inserted central catheter-PORT technique is an evolution of the standard arm-totally implantable vascular access device implant based on guided ultrasound venous access in the proximal third of the upper limb with subsequent placement of the reservoir at the middle third of the arm. A prospective study was conducted on 418 adult female breast cancer patients undergoing chemotherapy. The primary study outcome was peripherally inserted central catheter-PORT failure.

Results:

Median follow-up was 215 days. Complications occurred in 29 patients (6.9%) and failure resulting in removal of the device in 11 patients (2.6%). The main complication we observed was upper extremity deep vein thrombosis, 10 (2.4%); all patients were rescued by anticoagulant treatment without peripherally inserted central catheter-PORT removal. The main reason for removal was reservoir pocket infection: 4 (0.9%) with an infection rate of 0.012 per 1000 catheter days. Cumulative 1-year risk of failure was 3.6% (95% confidence interval, 1.3%–7.1%). With regard to the patients’ characteristics, body mass index <22.5 was the only significant risk for failure ( p = 0.027).

Conclusion:

The peripherally inserted central catheter-PORT is a safe vascular device for chemotherapy delivery that achieves similar clinical results as traditional long-term vascular access devices (peripherally inserted central catheter and arm totally implantable vascular access device, in particular) in breast cancer patients.
Representative volume element-based simulation of multiple solid particles erosion of a compressor blade considering temperature effect
Authors: Mohammadi Bijan , Khoddami AmirSajjad
Published: November 2019

Solid particle erosion is one of the main failure mechanisms of a compressor blade. Thus, characterization of this damage mode is very important in life assessment of the compressor. Since experimental study of solid particle erosion needs special methods and equipment, it is necessary to develop erosion computer models. This study presents a coupled temperature–displacement finite element model to investigate damage of a compressor blade due to multiple solid particles erosion. To decrease the computational cost, a representative volume element technique is introduced to simulate simultaneous impact of multiple particles. Blade has been made of Ti-6Al-4V, a ductile titanium-based alloy, which is impacted by alumina particles. Erosion finite element modeling is assumed as a micro-scale impact problem and Johnson–Cook constitutive equations are used to describe Ti-6Al-4V erosive behavior. In regard to a wide variation range in thermal conditions all over the compressor, it is divided into three parts (first stages, middle stages, and last stages) in which each part has an average temperature. Effective parameters on erosive behavior of the blade alloy, such as impact angle, particles velocity, and particles size are studied in these three temperatures. Results show that middle stages are the most critical sites of the compressor in terms of erosion damage. An exponential relation is observed between erosion rate and particles velocity. The dependency of erosion rate on size of particles at high temperatures is indispensable.
Efficacy of alemtuzumab over 6 years in relapsing–remitting multiple sclerosis patients who relapsed between courses 1 and 2: Post hoc analysis of the CARE-MS studies
Authors: Van Wijmeersch Bart , Singer Barry A , Boster Aaron , Broadley Simon , Fernández Óscar , Freedman Mark S , Izquierdo Guillermo , Lycke Jan , Pozzilli Carlo , Sharrack Basil , Steingo Brian , Wiendl Heinz , Wray Sibyl , Ziemssen Tjalf , Chung Luke , Margolin David H , Thangavelu Karthinathan , Vermersch Patrick
Published: November 2019

Background:

Alemtuzumab is administered as two annual courses for relapsing–remitting multiple sclerosis (MS). Patients may relapse before completing the two-course regimen.

Objective:

The objective was to evaluate 6-year outcomes in patients who relapsed between alemtuzumab Courses 1 and 2 (early relapsers).

Methods:

Post hoc analysis of patients from the Comparison of Alemtuzumab and Rebif® Efficacy in Multiple Sclerosis (CARE-MS) studies who enrolled in the extension.

Results:

Early relapsers (CARE-MS I: 15%; CARE-MS II: 24%) had more relapses in 1–2 years pre-alemtuzumab and higher mean baseline Expanded Disability Status Scale score than patients without relapse. Their annualized relapse rate declined from Year 1 (CARE-MS I: 1.3; CARE-MS II: 1.2) to Year 2 following Course 2 (0.3; 0.5) and remained low thereafter. Over 6 years, 60% remained free of 6-month confirmed disability worsening; 24% (CARE-MS I) and 34% (CARE-MS II) achieved 6-month confirmed disability improvement. During Year 6, 69% (CARE-MS I) and 68% (CARE-MS II) were free of magnetic resonance imaging (MRI) disease activity. Median percent yearly brain volume loss (Year 1: −0.67% (CARE-MS I); −0.47% (CARE-MS II)) declined after Course 2 (Year 6: −0.24%; −0.13%).

Conclusion:

Early relapsers’ outcomes improved after completing the second alemtuzumab course. These findings support administering the approved two-course regimen to maximize clinical benefit.

ClinicalTrials.gov registration numbers:

CARE-MS I, II, extension: NCT00530348, NCT00548405, NCT00930553.
Outgroup morality perceptions mediate secondary transfer effects from direct and extended contact: Evidence from majority and minority group members
Authors: Vezzali Loris , Di Bernardo Gian Antonio , Birtel Michèle D. , Stathi Sofia , Brambilla Marco
Published: November 2019

The secondary transfer effect (STE), defined as contact with a primary outgroup improving attitudes towards a secondary outgroup uninvolved in contact, has mainly been studied with reference to direct contact and considering attitude generalization as the main mediating mechanism. Using a majority (422 Italians) and minority (130 immigrants) adolescent sample from high schools in Italy, we examined outgroup morality perceptions as a new mediating mechanism, and tested for the first time whether the STE emerges for extended contact. Results revealed that the STE emerged for direct contact among the majority group and for extended contact among the minority group, and it was sequentially mediated by perceptions of morality towards the primary outgroup, and by attitudes towards the primary outgroup and perceptions of morality towards the secondary outgroup. The STE also emerged for direct contact among the minority group, with morality perceptions towards the secondary outgroup and attitudes towards the primary outgroup being parallel mediators. We discuss the theoretical implications of the findings, arguing that it is important to identify the conditions and underlying processes of the STE in order to reduce prejudice in the case of both majority and minority groups.
Xenophobia towards asylum seekers: A survey of social theories
Authors: Peterie Michelle , Neil David
Published: November 2019

In recent decades, there has been a global rise in fear and hostility towards asylum seekers. Xenophobia – or ‘fear of the stranger’ – has become a pressing issue in a range of disciplines. Several causal models have been proposed to explain this fear and the hostility it produces. However, disciplinary boundaries have limited productive dialogue between these approaches. This article draws connections between four of the main theories that have been advanced in the existing literature: (1) false belief accounts, (2) xenophobia as new racism, (3) sociobiological explanations and (4) xenophobia as an effect of capitalist globalisation. While this article cannot provide an exhaustive review of theories of xenophobia, it aims to present a useful comparative introduction to current research into the social aspects of xenophobia, particularly as these theories have been applied to asylum seekers. In bringing together divergent models, it also invites interdisciplinary engagement.
Student Demand and Institutional Diversification: The Case of England
Authors: Parry Gareth
Published: November 2019

Following a period of dramatic but largely unplanned expansion, government priorities for future growth include changing the pattern of demand for English higher education and widening participation in colleges and universities of all types. With reform of tuition fees tied to access agreements and new foundation degrees designed in association with employers, a diversity of institutional mission rather than formal stratification is the goal of post-binary policy. However, strategies to stimulate demand for new kinds of higher education are in tension with efforts to reduce disparities in participation in different parts of the system. In the case of England, it is argued, such policies prefigure a democratisation of access and a diversion of demand, albeit modest in scale and limited in reach.
The European Union as a Masculine Military Power: European Union Security and Defence Policy in ‘Times of Crisis’
Authors: Hoijtink Marijn , Muehlenhoff Hanna L
Published: November 2019

Against the background of a sense of crisis in the European Union and in international politics, European Union Member States have since 2016 increased their cooperation within the Common Security and Defence Policy, for example, establishing the European Defence Fund. Scholars have long pointed out that the European Union lacks the necessary ‘hard’ military power to influence international politics, subscribing to and constituting an image of the European Union as not masculine enough. We are critical of these accounts and develop a different argument. First, building on insights from feminist security and critical military studies, we argue that the European Union is a military power constituted by multiple masculinities. We consider the European Union to be a masculine military power, not only because it uses and aims to develop military instruments, but also because of how militarism and military masculinities permeate discourses, practices and policies within Common Security and Defence Policy and the European Union more broadly. We argue, second, that the crisis narrative allows the European Union to strengthen Common Security and Defence Policy and exhibit more aggressive military masculinities based on combat, which exist alongside entrepreneurial and protector masculinities. These developments do not indicate a clear militarisation of Common Security and Defence Policy, but, rather, an advancement and normalisation of militarism and the militarised masculinities associated with it.
Overexpression of MiR-146a-5p Upregulates lncRNA HOTAIR in Triple-Negative Breast Cancer Cells and Predicts Poor Prognosis
Authors: Liang Hongguang , Huang Weihua , Wang Yuandong , Ding Lingying , Zeng Lixian
Published: November 2019

MiR-146a-5p plays different roles in different types of cancers. We showed that miR-146a-5p and long noncoding RNA HOTAIR were both upregulated in triple-negative breast cancer. Follow-up study showed that high levels of miR-146a-5p and HOTAIR in tumor tissues were closely correlated with poor survival. MiR-146a-5p and HOTAIR were positively correlated in tumor tissues. MiR-146a-5p positively regulated HOTAIR triple-negative breast cancer cells, while HOTAIR showed no regulatory effects on miR-146a-5p expression. MiR-146a-5p and HOTAIR positively regulated the migration and invasion of triple-negative breast cancer cells. In addition, HOTAIR silencing attenuated the effects of miR-146a-5p. Therefore, overexpression of miR-146a-5p may promote triple-negative breast cancer cell invasion and migration by upregulating HOTAIR.
Prescription Opioid Use Among Hispanics/Latinos With Arthritis Symptoms: Results From the Hispanic Community Health Study/Study of Latinos
Authors: Perez Hector R. , Starrels Joanna L. , Gonzalez Sara , Vidot Denise C. , Hua Simin , Strizich Garrett M. , Zeng Donglin , Daviglus Martha , Gellman Marc D. , Kaplan Robert C.
Published: November 2019

Introduction:

To determine the prevalence of prescription opioid (PO) use among Hispanics/Latinos with arthritis symptoms and to characterize how demographic and cultural factors are associated with PO use.

Method:

Cross-sectional analysis of baseline visit data during 2008 to 2011 from the Hispanic Community Health Study/Study of Latinos, a population-based cohort study of 16,415 Hispanics/Latinos living in Chicago, Illinois, Miami, Florida, Bronx, New York, and San Diego, California. Included participants self-reported painful inflammation or swelling in one or more joints. Multivariate models controlling for physical and mental health scores were constructed to assess how demographic and cultural factors were associated with PO use.

Results:

A total of 9.3% were using POs at the time of the baseline visit. In multivariate models, persons of Cuban background (adjusted odds ratio [AOR] = 0.42, 95% confidence interval [CI; 0.21, 0.81]) and of Dominican background (AOR = 0.38, 95% CI [0.18, 0.80]) were significantly less likely to use POs compared with a reference group of persons of Mexican background. Greater language acculturation was also negatively associated with PO use (AOR = 0.68, 95% CI [0.53, 0.87]).

Conclusion:

POs were used relatively uncommonly, and use showed marked variation between Hispanic/Latino groups. Future study should determine mechanisms for why greater use of English among Hispanics/Latinos might influence PO use.
Linked color imaging for the detection of early gastrointestinal neoplasms
Authors: Shinozaki Satoshi , Osawa Hiroyuki , Hayashi Yoshikazu , Lefor Alan Kawarai , Yamamoto Hironori
Published: November 2019

In routine upper and lower gastrointestinal endoscopy, overlooking neoplastic lesions is inevitable even for well-trained endoscopists. Various methods have been reported to improve the detection of gastrointestinal neoplasms including chromoendoscopy, special endoscopes, and processor and image enhanced technologies. Equipment-based image enhanced endoscopy (e-IEE) using narrow band imaging (NBI) and blue laser imaging (BLI) is useful to characterize known lesions with magnification at a close-up view. However, they are not useful for the early detection of superficial, pale neoplasms, or both because of the weak image at a distant view in a wide lumen such as the stomach or colon. Linked color imaging (LCI) is a novel pre- and post-processing technology developed by Fujifilm Corporation that has sufficient brightness to illuminate a wide lumen. LCI delineates early gastric cancers as orange–red and intestinal metaplasia as purple. LCI improves the adenoma detection rate in the colon and decreases the polyp miss rate. LCI contributes to the detection of superficial lesions throughout the gastrointestinal tract by enhancing the color contrast between the neoplasm and the surrounding mucosa. LCI can distinguish them by their specific color allocation based mainly on the distribution of capillaries. The authors believe that moving forward, LCI should be used in routine upper and lower gastrointestinal endoscopy.
Current approach to the diagnosis of atherosclerotic coronary artery disease: more questions than answers
Authors: Nelson Adam J. , Ardissino Maddalena , Psaltis Peter J.
Published: November 2019

Despite its commonality in routine clinical practice, the approach to a diagnosis of atherosclerotic coronary artery disease remains complex and, in part, contentious. The traditional dogma linking ischaemia to hard clinical outcomes has been questioned and reframed over the years; rather than being a predictor of hard clinical outcomes, the degree of ischaemia may simply be a marker of atherosclerotic disease burden. A renewed interest in the imaging of plaque burden has spawned the contemporary role of CT imaging for not only diagnosis and prognosis, but also for dictating downstream management. As the technology develops and evidence expands, decisions on investigative modalities remain centred around patient factors, local availability, test performance and cost. This review summarizes the available methods for diagnosis in the symptomatic patient and provides an overview of the current evidence behind functional and anatomical approaches.
Ischemic and bleeding outcomes of triple therapy in patients on chronic anticoagulation undergoing percutaneous coronary intervention: A meta-analysis of randomized trials
Authors: Dahal Khagendra , Mustafa Usman , Sharma Sharan P , Apte Nachiket , Bogabathina Hari , Hanna Magdy , Watti Hussam , Azrin Michael , Lee Juyong , Mina Goerge , Katikaneni Pavan , Modi Kalgi
Published: November 2019

Background

Triple therapy (TT) that includes oral anticoagulation and dual antiplatelet therapy is recommended in patients who are on chronic anticoagulation and undergo percutaneous coronary intervention (PCI). The randomized clinical trials (RCTs) comparing the effectiveness and safety of TT compared to double therapy (DT), which consists of an oral anticoagulation and one of the P2Y12 inhibitors, have shown increased risk of bleeding; however, none of the individual studies were powered to show a difference in ischemic outcomes. To compare the clinical outcomes of TT and DT, we performed this meta-analysis of RCTs.

Methods

Electronic search of PubMed, EMBASE and Cochrane CENTRAL databases was performed for RCTs comparing TT and DT in patients who were on oral anticoagulation (Vitamin K antagonist or non-vitamin K antagonist oral anticoagulant) who underwent PCI. All-cause and cardiovascular mortality, myocardial infarction (MI), stroke, stent thrombosis (ST) and TIMI major and minor bleeding were the major outcomes.

Results

An analysis of 5 trials including 10,592 total patients showed that TT, compared to DT, resulted in non-significant difference in risk of all-cause [odds ratio (OR); 1.14;95% confidence interval (CI):(0.80–1.63); P = 0.46) and cardiovascular mortality [1.43(0.58–3.36); P = 0.44], MI [0.88 (0.64–1.21); P = 0.42], stroke [1.10(0.75–1.62); P = 0.63] and ST [0.82(0.46–1.45); P = 0.49]. TT, compared to DT resulted in higher risk of TIMI major bleeding [1.61(1.09–2.37); P = 0.02], TIMI minor bleeding [1.85(1.23–2.79); P = 0.003] and TIMI major and minor bleeding [1.81 (1.38–2.38); P < 0.0001; I2 = 52%].

Conclusion

Compared to DT, the patients receiving TT are at a higher risk of major and minor bleeding with no survival benefit or impact on thrombotic outcomes.
Blackfish and SeaWorld: A Case Study in the Framing of a Crisis
Authors: Waller Randall L. , Iluzada Christina L.
Published: November 2019

This research focuses on the crisis that the documentary Blackfish precipitated at SeaWorld. The study begins with a brief account of the growth and evolution of SeaWorld and the financial and reputational damage that followed Blackfish’s release in 2013. A literature review of framing and frame theory follows. Next, the three issue-related, transformative frames embedded in the text/video of Blackfish are identified and analyzed; then the three main counter frames deployed by SeaWorld are identified and analyzed. The conclusion discusses how and why Blackfish prevailed in this high-profile framing contest. It does so by discussing the resonance, coherence, and credibility of the documentary’s anticaptivity narrative and its superiority over SeaWorld’s counterframing campaign. Perhaps even more important, the conclusion briefly examines how the tectonic shift in late-20th-century public opinion regarding animal rights—the kairotic backdrop of this crisis—forced SeaWorld to fundamentally change its business model in order to meet the dictates of this new ethos and to reestablish its postcrisis legitimacy.
An Educational Intervention to Mothers Improved the Nutritional Status of Mexican Children Younger Than 5 Years Old With Mild to Moderate Malnutrition
Authors: Sánchez-Encalada Sonia , Talavera-Torres Myrna Mar , Wong-Chew Rosa Maria
Published: November 2019

Malnutrition in children younger than 5 years old has persisted in time (13.5% in 1988 to 12.3% in 2012) in Mexico City. A quasi-experimental study was performed. An educational intervention was given twice a month for 6 months to mothers of mild to moderate malnourished children 1 to 5 years old. Weight, height, and body mass index of the children were obtained at the beginning and 3 and 6 months after the intervention. Thirteen mothers and 15 children were included. The baseline mean weight/age in Z score was −1.49 ± 0.65, which improved to −1.19 ± 0.60 ( P = 0.001; per protocol analysis). Linear regression analysis showed a P of 0.006 of the mothers’ adherence to improve children’s weight. The educational intervention decreased the weight deficit after 6 months with the same economic resources of the family; hence, the adherence of the mothers to the educational intervention is relevant to improve the nutritional status of their children.
ProHealth or HealthCore: Teaching Students About Reality Creation in Organizational Life
Authors: Bright David S.
Published: November 2019

This exercise introduces students to reality creation processes in organizational life (e.g., self-fulfilling prophecy, Pygmalion effects, etc.) as a theoretical perspective that must be understood to design transformational organizational change. By comparing the differential effects of conventional and appreciative questions, the experience also exposes students to their biases of reality creation. It illustrates how questions can be used to invite a shift from a conventional to an appreciative or positive narrative of reality. Students may also explore how inquiry may be used to inspire change in organizations.
The Arena: An Activity to Foster Teamwork, Communication, and Cooperation in and Across Teams
Authors: McCauley Kelly Davis
Published: November 2019

The Arena activity is an in-class, experiential learning exercise that requires student teams to navigate and assist a blindfolded team member through a maze-like setting. The goal of the activity is to seek and find all of the team’s assigned objects. However, only the blindfolded team member can collect these objects in The Arena. This activity is applicable to courses focusing on the development of soft skills such as teamwork, cooperation (versus competition) across teams, communication, and leadership/followership. This article provides a description of the activity, options for variations of The Arena, suggestions for debriefing the activity, specific debriefing questions, and sample student answers to the debriefing questions.
Book review: Manoranjan Byapari, Interrogating My Chandal Life: An Autobiography of a Dalit
Authors: Sarangi Jaydeep
Published: November 2019

Manoranjan Byapari, Interrogating My Chandal Life: An Autobiography of a Dalit (translated by Sipra Mukherjee). Kolkata: Sage-Samya, 2018, ₹550, 356 pp. (paperback). ISBN: 9381345139, 9789381345139.
A Cadaveric Load Analysis of the Supramalleolar Osteotomy In The Setting of an Osteochondral Pseudolesion: Quantifying Chondral Off-loading
Authors: Tracey Joseph , Glisson Richard , Verschae Gregorio , Wagner Emilio , Gross Christopher , Easley Mark
Published: November 2019

Category:

Ankle, Ankle Arthritis

Introduction/Purpose:

The supramalleolar osteotomy (SMO) serves as a means to alter joint load transmission and shield damaged areas of cartilage within the tibiotalar joint. The aim of this study was to directly measure the changes in pressure attributed to varying degrees of SMOs (varus and valgus); with and without an osteochondral (OCD) pseudolesion, and in multiple ankle alignments (Dorsiflexion, neutral, and plantarflexion). We hypothesize measurement metrics to be reduced with increasing degrees of SMO.

Methods:

6 cadaver specimens were in included in the biomechanical study (sectioned at the mid-tibia). A pressure sensor was used to measure load, load area, and peak pressure within the tibiotalar joint. SMOs of 3,6,9, and 12 degrees in varus or valgus were performed. A servohydraulic machine was used to transmit 400 and 800 N through the specimens; in 10 degrees of dorsiflexion, neutral, or in 10 degrees of plantarflexion during load transmission. Measurements were performed in undisturbed joints, followed by re-measurement in the presence of a created 9 mm diameter pseudolesion.

Results:

Load was not changed (only significant changes reported) in the presence of a lesion. For the load, it was more influenceable at 800 N, changes were observed in higher degree SMOs, and changes were only observed in neutral and dorsiflexion. Changes in area were only observed when 12 degrees of varus or valgus SMOs were used. Peak Pressure was the only modifiable metric in the presence of a pseudo-lesion, reductions were more common at 800 N, and in the absence of a pseudolesion there was an incremental reduction in medial peak pressure when increasing varus SMOs were performed (dorsiflexion).

Conclusion:

Medial peak pressure tended to decrease with varus SMOs in neutral and dorsiflexion. Medial load tended to decrease with varus osteotomies in 10 degrees of dorsiflexion. A 12 degree varus SMO was the only SMO to influence a pseudolesion.
Antivascular Endothelial Growth Factor Treatment Might Be Continued Even After Vitrectomy for Endophthalmitis in Neovascular Age-Related Macular Degeneration
Authors: Michalewska Zofia , Nawrocki Jerzy
Published: November 2019

Purpose:

This article studies visual outcome and frequency of antivascular endothelial growth factor (anti-VEGF) injections continued in patients with neovascular age-related macular degeneration (AMD) who had an earlier vitrectomy for postinjection endophthalmitis.

Methods:

A retrospective interventional study was conducted reviewing our database for patients with a diagnosis of endophthalmitis in the course of anti-VEGF injections. Endophthalmitis diagnosis was made on clinical examination of pain, rapid decrease in visual acuity (VA), conjunctival hyperemia, hypopyon, and vitritis. In all eyes, core vitrectomy with intravitreal antibiotics was performed. Spectral-domain optical coherence tomography was performed monthly before and after surgery during follow-up. Anti-VEGF injections were continued after surgery in all cases.

Results:

Eight eyes with postinjection endophthalmitis were included. Mean VA immediately before endophthalmitis was 20/50 Snellen with a mean of 19 intravitreal anti-VEGF injections ( P = .45). At time of endophthalmitis diagnosis, mean VA was 20/1000 (range, 20/2000-20/200). Mean time from injection to when the patient noted first symptoms was 4.3 days (range, 1-8 days). Mean time from first symptoms to surgery was 12 hours (range, 2.5-26 hours). Final mean VA at the end of follow-up (range, 12-84 months) did not statistically differ from VA at the visit immediately before endophthalmitis diagnosis ( P = .69). Mean frequency of injections after vitrectomy did not significantly differ from the presurgical course of treatment ( P =.97).

Conclusions:

Anti-VEGF treatment might be continued after vitrectomy for endophthalmitis and results in satisfactory anatomical and visual outcome. Surgery did not influence the frequency of anti-VEGF injections for neovascular AMD.
Apocalypse yesterday: Posthumanism and comics in the Anthropocene
Authors: Menga Filippo , Davies Dominic
Published: November 2019

It is widely recognised that the growing awareness that we are living in the Anthropocene – an unstable geological epoch in which humans and their actions are catalysing catastrophic environmental change – is troubling humanity’s understanding and perception of temporality and the ways in which we come to terms with socio-ecological change. This article begins by arguing in favour of posthumanism as an approach to this problem, one in which the prefix ‘post’ does not come as an apocalyptic warning, but rather signals a new way of thinking, an encouragement to move beyond a humanist perspective and to abandon a social discourse and a worldview fundamentally centred on the human. The article then explores how the impending environmental catastrophe can be productively reimagined through graphic narratives, arguing that popular culture in general, and comics in particular, emerge as productive sites for geographers to interrogate and develop posthuman methodologies and narratives. Developing our analysis around two comics in particular – Here and Mad Max: Fury Road – we show how graphic narrative can help us to move beyond the nature–society divide that is rendered anachronistic by the Anthropocene.