bluuebunny/crossref_metadata_2025 huggingface dataset:
Industri Kreatif Pengolahan Buah Nanas Menjadi Varian Keripik untuk Meningkatkan Perekonomian Masyarakat di Desa Lendang Nangka Utara
Authors: Nurlatifa  , Ainul Qusyairi  , Baiq Usniati  , Dina Aulia  , Ely Aulia Safitri  , Emil Ismaya  , Ida Fauziah  , Ira Madiana  , Irfanul Furqan  , Laelatul Fajri  , Lalu Muhammad Maqbul Alghifari  , Muhammad Zainul Majdi  , Nur Gita Suciyati  , Riki Azwari  , Yusri  , Yuliatin  , Bagdawansyah Alqadri
Published: December 2021

Industri kreatif pengolahan buah nanas menjadi varian keripik merupakan suatu terobosan yang dilakuakan untuk memanfaatkan sumber daya alam berupa nanas yang melimpah di Desa Lendang Nagka Utara, Kecamatan Mabagik, Kabupaten Lombok Timur. Pengolahan buah nanas menjadi varian keripik ini dilakukan untuk memanfaatkan sumber daya alam yang melimpah dan juga sebagai langkah untuk meningkatkan ekomomi masyarakat setempat. Tujuan kegiatan ini adalah untuk memberdayakan masyarakat yang ada di Desa Lendang Nangka Utara menajdi masyarakat yang berdaya saing berbasisi industri kreatif. Adapun tahapan dan metode dari kegiatan ini yaitu sosialisasi program (metode diskusi), pembentukan tim pengolahan (metode kolaboratif dan kooperatif) dan pelatihan (metode diskusi dan praktik). Hasil dari kegiatan berupa meningkatnya keterampilan masyarakat dalam pengolahan buah nanas menjadi varian keripik sehingga dapat berdampak pada peningkatan ekonomi masyarakat.
Desiminasi Galur Harapan dan Teknologi Budidaya Padi Beras Merah Tipe Ideal Pada Kelompok Tani Mertha Sari Desa Lembuak Kecamatan Narmada Kabupaten Lombok Barat
Authors: IGP Muliarta Aryana  , AAK Sudhramawan  , NW Sri Suliartini
Published: December 2021

Galur harapan  padi beras merah tipe ideal  merupakan  salah satu padi fungsional beras merah  belum banyak dikenal  petani dan masyarakat  luas baik  dalam hal asal usulnya, budidaya maupun  manfaatnya bagi kesehatan  manusia. Tujuan dari kegiatan ini adalah Memperkenalkan asal usul terbentuknya galur harapan padi beras merah, manfaat serta  teknologi budidaya kepada  para petani melalui  demontrasi plot.  Metode yang digunakan adalah   metode ceramah, diskusi dan praktik lapang berupa demontrasi plot (Demplot). Waktu pelaksanaan mulai  Juni-September 2021. Demplot dilaksanakan di  lahan sawah Unram Farming. Kelompok tani yang dilibatkan adalah kelompok tani Merha Sari di desa Lembuak kecamatan Narmada kabupaten Lombok Barat.  Hasil kegiatan menunjukkan, bahwa anggota kelompok Tani Mertha Sari  desa Lembuak  Kecamatan Narmada  kabupaten Lombok Utara melalui kegiatan  penyuluhan  telah  paham asal usul dari Galur harapan padi beras merah Tipe Ideal, deskripsi,  manfaat serta paham akan Teknologi Budidayanya. Melalui kegiatan demplot kelompok tani dapat melihat secara langsung  penampilan galur harapan padi beras merah  tipe ideal  mulai dari pertumbuhan vegetatif, generatif,  saat panen, panen. Petani berkeinginan untuk menanam apabila ada pasar yang menampung
Development of Video Based on Pop Up Questions Integrated Religious Character Human Digestive System Materials
Authors: Nurhidayah Nurhidayah , Jumaeri Jumaeri , Susilaningsih Endang
Published: December 2021

This study aims to test the validity, practicality, and effectiveness of pop-up questions-based learning videos integrated with religious characters of the human digestive system. The subjects of this study were students of class VIII A and VIII C of MTs Mazro'illah, Lubuklinggau City. This research is a type of research and development (R&D) that uses the ADDIE (Analysis, Design, Development, Implementation, Evaluation) model. The data collection instruments in this study consisted of interview guides, expert validation questionnaires, practicality questionnaires, and test sheets. The results of the research data analysis showed that the experts stated that the three learning videos developed were very valid with an average score of 89.70% for the first video, 91.40% for the second video, and 90.80% for the third video. The learning videos that have been declared valid are then tested on students to find out the practicality of the learning videos developed. The results of the practicality questionnaire showed good responses by students and teachers with an average score of 85 and 84, respectively. The learning videos developed were then implemented for students to determine the effectiveness in aspects of knowledge and attitudes. The test results show that the ability of the students' knowledge aspect is still in the poor category with an average score of 55.20%, while the attitude aspect of students shows different things with an average score of 92.50% which is included in the very good criteria. Based on the results of this study, the pop-up question-based learning video integrated with the religious character of the human digestive system material was declared to be very valid, practical, and effective in the aspect of religious attitudes to be used in learning
Meta Analysis: The Effect of Edmodo Assisted Physics Learning Media on Student Learning Outcomes
Authors: Nazifah Naurah , Azmi Nurul , Nurhaliza Putri , Desnita Desnita
Published: December 2021

The industrial revolution 4.0 requires humans to have 21st century skills. In essence, education is expected to produce students who have the quality to live as individuals who are creative, innovative, intelligent, and globally competent. The purposes of this study are to: 1) Determine the effect of Edmodo media on student learning outcomes in the aspect of high school level class levels. 2) Determine the effect of Edmodo media on student learning outcomes on the material used. 3) Determine the effect of Edmodo media on student learning outcomes. The type of research used is meta-analysis. The articles analyzed in this study amounted to 15 articles published in 2014-2021. The average overall effect size of using Edmodo-assisted learning media on high school students' learning outcomes is 2.51 in the high category. The Edmodo-assisted physics learning media provides an effect size on the XI SMA level with an average of 2.91 in the high category, the Edmodo-assisted physics learning media provides an effect size on the XI SMA level with an average of 2.15 in the high category. The highest average value of the effect size of Edmodo-assisted learning media on global warming material with a value of 7.50 in the high category, while the lowest average value of the effect size of Edmodo-assisted learning media on optical instrument materials with a value of 0.87
Multiparity as a risk factor for congenital toxoplasmosis: a cross-sectional study
Authors: dos Santos Priscilla Vilela , de Toledo Débora Nonato Miranda , Machado Bianca Alves Almeida , Silva Zolder Marinho , de Andrade-Neto Valter Ferreira , Guimarães Nathalia Sernizon , Talvani André
Published: December 2021

Background

Congenital toxoplasmosis (CT) is caused by placental transfer of Toxoplasma gondii to the fetus, which can generate neurological, neurocognitive deficits, or death. Appropriate preventive strategies are required for infection-related risk factors. This study assessed the prevalence of T. gondii infection and the factors associated with CT in pregnant women with assistance from the Public Health Service at Ouro Preto, Brazil.

Methods

This cross-sectional study was conducted between April and December 2020. Pregnant women (n=131) aged between 13 and 46 years, were recruited and evaluated for specific IgM/IgG antibody levels against T. gondii. A structured questionnaire was applied to determine the socioeconomic, environmental, gestational, clinical, and dietary patterns.

Results

The prevalence of T. gondii was 45.8% (n = 60) in which multiparas revealed to be more exposed to infection and were 2.6 times more likely to become infected with the parasite compared to primiparas, (odds ratio, OR=2.60; 95% confidence interval, CI=1.25-5.39). A high prevalence of T. gondii seropositivity was found to be related to the absence of basic sanitation at home. In conclusion, multiparas constitute risk factor for CT.

Conclusions

Educational and preventive measures should be intensified in uninfected multiparas to raise awareness about the potential risks of contact with T. gondii.
Astudy of some aspects of reproductive Performance in rabbits treated with Hydrocortisone
Authors: Al- Ar rak J. K.
Published: December 2021

This experiment was carried out to study the changes in some of the structural – functional and biochemical aspects that are related to reproductive performance as a result of using glncocorticoid - hydrocortisone. Twelve adult male rabbit were divided into two equal groups : control and treatment. During pretreatment period ( Five days) blood samples were collected from all animals on every other days . During the treatment period (14) days each animal of the treatment group was injected daily , intramuscularly with hydrocortisone . Rabbit of the control group were injected with the same dose of normal physiological saline. Blood samples were collected as described above until (48) hours after last injection . All animals were scarified and samples from testicular tissue were taken to study structural – functional aspect. 

Statistical analysis showed significant (P < 0.05) decrease in plasma testosterone of hydrocortisone treated rabbits, plasma levels of ICSH of both treatment and control groups of rabbits were parallel to each other (P< 0.05).
Applied study for general inhalation anaesthesia in sheep
Authors: A. Mohannad S. , A. Nabih M. , J. Ayad A.
Published: December 2021

General inhalation anaesthesia has been evaluated in twelve local sheep, which were divided in two equal groups. First group anaesthtized by induction with intravenous injection of ( Atropine sulfate 0.4 mg/kg B.W) and after 10 to minuts ( xylazine 0.02 mg/kg . B.W.) and ( Ketamine 10 mg/kg . B.W.). While the second group has been inducted with ( xylazine 0.02 and pentobarbiton sodium 15 mg /kg B.W) with intravenons injection premidirated with (Atropine sulfate 0.4 mg/kg B.W). 

The general anaesthesia has been maintained in both groups with inhalation of halothane and oxygen 1-2% concentration by (( To and Fro)) inhalation closed system. The changes in the parameters of pulse rate, respiratory rate, rectal temperature and ruminal contractions has been considered from time 0 to 60 minutes to evalute the general anaesthesia .xylazine and ketamine induction followed with halothane show effective and safe gerenal anaesthesia with excellent muscle relaxation , analgesia and ensured rapid and safe recovery with minium cardio-pulmonary depression .
Pathological and histochemical changes in the lungs of rabbits experimentally infected with P.seudomonas aeruginosa
Authors: H. AL. Kutbi, S. , Alwan M. J.
Published: December 2021

The main objective to this study is to demonstrate certain aspects of pathological and histochomical changes in the lungs of rabbits experimentaly infected with P.aeruginosa . 

Twelve white Newzoland rabbits of 12-16 weeks old were used . they were randomaly divided into two groups. The first group (6 animals ) were given single intraperitoneal, dose of 108 CFU of P. aeruginosa . The second group (6 animals ) maintained as a control and was inoculated with 1 ml of sterial normal saline by the same route of the first group. All the animals were sacrificed on day three post – inoculation. 

The pathological exmination showed acute suppurative reaction in pulmonary tissue together with lymphocytic aggregation around airways and blood vessels. The histochomical study revealed that the granules of goblet cells and submucesal glands of the lung in normal rabbits were of neutral mucopolysaecharides and little sialomucin, these substances changed to sulfated acid mucopolysaccharide and sialomucin in the infected animals.
Effect of kerosene combustion gases on the pulmonary tissue in mice
Authors: Al-Omar Muthanna A. , Al-Zamily Adil H.
Published: December 2021

This study aims to throw light on the harmful effect of kerosene combustion on the respiratory system in mice. Experimental animals were exposed to combustion gases of kerosene for 2, 4 and 6 hours/day for 5 days a week. Exposure was lasted for 8 consecutive weeks. Histopathological changes were examined in trachea and lung tissues. Results showed different stages of tissue damages were emphysema was the most severe. Filtration of lymphocytes was also remarkable accompanied by increase in alveolar macrophages. There was evident and direst correlation between exposure time and the severity of effects.
Effect of HMG extracted from urine of menopausal women on utero-ovarian weights and percentage of embryos and births of mice.
Authors: AL-Arrak J. K.
Published: December 2021

Urine samples were collected and pooled from four menopausal women , 47-55. years old, for extraction of gonadotropines ( LH & FsH) according to the method of Albert ( 1955 ) For evaluation the hormonal extract from menopausal women the following parameter were studied: a- Effect of crude hormonal extract on utero-ovarian weights of immature mice. b- Counting number of embryos & alive births in mice 

treated with crude extract. There was a significant effect of hormone extracted fiom menopausal women on utero-ovaian weights for immature mice. The crude extract caused a significant increase in number of embryos and alive Lebirths compared with saline-treated mice , it is concluded that crude extract from urine of menopausal women have highly biological activity for increase fertility in female mice.
Clinical and Hematological Parameters Study of sheep infected by Theileria SPP
Authors: A. AL–Amiry A.M.
Published: December 2021

A Study of clinical and haematological changes in Awassi stock of sheep that had schizonts of Theileria spp. In Abu – Greeb region were conducted. Seventy three blood samples were collected from jugular vein of different ages, 60 had schizonts indicating an infection rate 82.19%. There were no great evidence of variation in clinical and haematological features between infected and non infected sheep.
on some normal hematological values in foals and arabian horses at different ages
Authors: Sultan A. Sh.
Published: December 2021

Hematological values of twenty normal male foals at 1-6 months , 7-12 months and sixty Arabian horses at 1-5 years old were estimated respectively. Red blood cell count ( RBCS), hemoglobin concentration (Hb), packed cell volume (PCV% ), mean corpuscular volume (MCV) ; mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), differential leukocyte count, total serum protein were determined using several laboratory techniques. These changes of these parameters were presented in tables in relation to the ages of these animals.
Molecular detection of Mycoplasma agalactiae and Mycoplasma capricolum in mastitic and non mastitic milk of goats by using Real Time Polymerase Chain Reaction
Authors: Jameel Mohanad M. , Hasso Saleem M.
Published: December 2021

A total of 200 samples were collected from 100 goats from more than one regions within the three governorates (Sulaimani, Erbil and Duhok); all these samples were tested by California mastitis test and these showed the following results: 103 samples (51.50%) were negative in all governorates, 28(14.00%) were trace, 35(17.50%) were (+) mark and 34(17.00%) were (++) mark. Clinical mastitis was observed on 93 out of 200 half udder of goats, in the three governorates; 37(18.5%) were acute mastitis, 27(13.5%) were sub acute mastitis and 19(9.5%) were Chronic mastitis. Examination of extracted DNA by Real Time Polymerase Chain Reaction out of 200 DNA extracted from milk samples of goats only 10 (5.00%) were positive for Mycoplasma agalactiae in the three governorates, 8(80%) from mastatic milk samples and 2 (20%) from non mastatic milk samples in result of M. agalactiae. For Mycoplasma capricolum 6 (3.00%) were positive and all were from mastatic milk.
Some physiological and chemical properties of horse and cow blood samples under effect of some different types of anticoagulants
Authors: Ismail Muna M. , I. Ali Hiba , S.Najm Ikbal , Y. Khadier Nooralden , M. Rasheed Yasin , A. Jasim Riyam , Kh. Khalil Zakia
Published: December 2021

The purpose of the present study is to determine and compare the anticoagulants, Ethylene diamine tetra acetic acid, Sodium oxalate, Sodium citrate and heparin in blood samples of horse and bull, through estimation of (Hemoglobin, Packed Cell Volume and Plasma Platelets Count) and  plasma physical properties (clarity and volume) and some chemical properties (pH and calcium ion concentration). Five Blood samples were obtained from five stallions and five bulls (20 ml/sample) and were divided as 5 ml in four test tubes containing Ethylene diamine tetra acetic acid, sodium oxalate, sodium citrate and heparin at the College of Veterinary Medicine, University of Diyala. Hemoglobin and packed cell volume were estimated immediately and then the blood samples were centrifuged for 15 min. at 3000 rpm to obtain plasma for evaluating the physical and chemical properties specified above. The horse blood samples pertaining data had no significant elevation in hemoglobin concentration and packed cell volume in Ethylene diamine tetra acetic acid group as compared to other groups, beside having no significant changes in pH between the four treated groups while there was a significant increase in plasma volume of oxalate and citrate as compared to Ethylene diamine tetra acetic acid and heparin, and there was a significant increase in plasma platelet count of Ethylene diamine tetra acetic acid group as compared to heparin. As well there was a significant decrease of calcium ion concentration in Ethylene diamine tetra acetic acid, oxalate and citrate as compared to heparin, while the results of bull blood samples revealed that the hemoglobin and Packed Cell Volume were significantly higher in heparin group than in the oxalate and citrate groups with non significant differences with Ethylene diamine tetra acetic acid group. The plasma obtained from different types of anticoagulants appeared with a high degree of clarity, and the volume of plasma had no significant increase in oxalate and citrate group as compared to other groups. The Plasma Platelet Count and calcium concentration significantly increased in heparin group as compared to other groups. In conclusion, the Ethylene diamine tetra acetic acid was more reliable for horse blood samples while the anticoagulant heparin was more reliable anticoagulant for bull blood samples.
Histomorphological investigation of tongue of Porcupine Hystrix cristate
Authors: Kadhim Abdularazzaq Baqer
Published: December 2021

Anatomical and histological explorations of the tongue in ten adult male Porcupine (Hystrix cristata) collected from AL-Diwanyha city by the hunter, after porcupine prepared the tongue illustrious after that the position, shape dimensions were enrolled. The square-shape of body, thicken less steadily toward caudal part of tongue. Root was tends caudally in the direction of the epiglottis. Torus linguae found on the caudal part of the dorsal surface of the tongue. In the end of lateral surface of tongue have foliate papilla osculate the premolar teeth. The length, apex, body and root of the tongue were (7.6±0.66, 1.25±0.23, 4.95±0.2, and 1.4±0.26 cm), respectively. The width, apex, body, and root of the tongue were (1.80±0.77, 0.35±0.49, 1±0.22 and 0.45±0.14, respectively. In the dorsal and lateral surface have muscle fibers from skeletal type and loose connective tissue bounded by keratinized stratified squamous epithelium while in the ventral lingual surface were non-keratinized. In the dorsal surface of body there were filiform papillae, but less at the lateral surface of the body. While the shape of circumvallate papillae was similar to furrow, and there was taste buds on the both dorsal and lateral sides of the tongue. Fungiform papillae had wide curved keratinized surface, with taste buds on the dorsal surface. Lamina propria and submucosa was loose connective tissue with more of collagen fiber.
Effect of Zinc Oxide nanoparticals preparation from Zinc Sulphate (ZnSo4) against gram negative or gram positive microorganisms in vitro
Authors: S Khitam S. , E.D Alhtheal , J.B. Azhar
Published: December 2021

This research aims to prepare ZnO NPs by using chemical bath deposition way from ZnSO4 and NaOH as starting materials. It was examined by X-ray diffraction, Scanning Electron Microscopy, Zeta potential and Fourier Transformation Infrared. Scanning Electron Microscopy images showed various morphological changes of ZnO nanoparticles obtained by the above method and the different magnification Scanning Electron Microscopy images of the nanoparticle and confirms that the Nano flowers are grown with well-defined morphology and diameters varying between 60-110 nm. The effect of Zinc oxide nanoparticles against bacteria staphylococcus aureus, E.coli and Pseudomous aeruginosa showed the ability of this substance to inhibit the growth of all types of bacteria in different concentrations. The percentage of survival bacteria was (2, 3.7 and 6%) for E.coli bacteria and (1, 1.5 and 5 %) for Pseudomous aeruginosa bacteria, while the percentage was (0.8, 1 and 1.5 %) for staphylococcus aurous respectively for all concentration.
Study of some virulence factors of Aeromonas Spp. isolated from stool samples of children with diarrhea
Authors: Talib Hashim Saba , Nema Mahmoud Mohammed
Published: December 2021

Three hundred samples of stool were collected from children, who are suffering from diarrhea, during the period from October to December 2016 at Fatima Al Zahra and Shaheed al-Sadr hospitals. All bacterial isolates have been submitted to the cultural, microscopical, biochemical examinations, and Vitek 2 system identification to identify Aeromonas isolates. All the isolates under study were tested for their ability to the production of certain factors associated with virulence. It has been concluded that 12 (4%) of collected samples were positive to Aeromonas Spp. The virulence factors of Aeromonas spp. were detected and showed that all the isolates have the ability to produce haemolysin, protease, lipase, phospholipase, gelatinase enzymes, and biofilm on Congo red agar.
The immune response of rabbits immunized by Salmonella typhimurium and Lactobacillus acidophilus
Authors: Al-Samarraae Ikram A. A. , A. Kareem Alaa
Published: December 2021

Antigens prepared from sonicated Salmonella typhimurium (KWCSA-ST) and Lactobacillus acidophilus (KWCSA-LBA) were used to evaluate synergistic effect on interlukine production (IL-2, IL-4) and Immunoglobulin-G (IgG) which were evaluated by using Enzyme Linked Immunosorbent Assay and Delayed Type Hypersensitivity-skin test at day 20 post  immunization. Twenty five rabbits of both sexes, 2-3 Kg body weight, were divided into five equal groups; the first group immunized by KWCSA-ST (1000 µg/ml) and KWCSA-LBA (1000 µg/ml), the second group by KWCSA-ST (1000 µg/ml) and KWCSA-LBA (500 µg/ml), the third group by KWCSA-ST (1000 µg/ml) as positive control, the fourth group by KWCSA-LBA (1000 µg/ml) as positive control and the fifth group was injected by P.B.S. (pH7.2) as negative control group subcutaneously. The result of delayed type hypersensitivity showed an increase in the means of erythema and induration in the 1st group after 24hrs and 48hrs while the 4th group recorded the lowest mean after 24hrs and 48hrs. These means showed significant differences (P˂0.05) compared with injection by 1:2 and 1:4 diluted Ag. While the results of IgG showed that the highest concentration was at 35th day in the first group while the lowest concentration at 35th day in the fourth group with significant differences (P<0.05). Also the high concentration of IL-2, IL-4 was recorded in the first group at 35th day and the lowest concentration was in the fourth group at 35th day with significant differences (P<0.05); also the results showed significant differences (P<0.05) between the 1st, 2nd, 3rd compared with 4th and 5th groups.
Gerenciamento da terapia medicamentosa em pacientes com tuberculose e HIV/aids: série de casos
Authors: RESENDE Natália H. , SOUZA Jonathan A. , MARTINS Úrsula C. , REIS Adriano M. , MIRANDA Silvana S. , CARVALHO Wânia S.
Published: December 2021

Objetivos: Descrever casos de pacientes com coinfecção tuberculose (TB) e HIV/aids acompanhados em um Hospital Referência em doenças infecciosas. Identificar, classificar e resolver os Problemas Relacionados ao uso de Medicamentos (PRM). E classificar a situação clínica e farmacoterapêutica. Métodos: Para a identificação, classificação e resolução do desfecho de PRM bem como a classificação da situação clínica e farmacoterapêutica, utilizou-se a metodologia Pharmacotherapy Workup. Trata-se um estudo observacional, descritivo, longitudinal, do tipo série de casos realizado em Hospital de Referência terciária em Belo Horizonte, seguindo as diretrizes CARE da Enhancing the QUAlity and Transparency Of health Research (EQUATOR). Foram incluídos pacientes coinfectados com TB e HIV/ aids, expostos ao tratamento preconizado pelo Ministério da Saúde, com 18 anos ou mais, de ambos os sexos, acompanhados por um período mínimo de seis meses. Resultados: Foram descritos seis casos de pacientes coinfectados com tuberculose e HIV/aids. A média de encontros com o farmacêutico foi de 6,33 (desvio padrão=0,82). Foram identificados 69 PRM, dos quais 40/69 (58,0%) relacionados à adesão, 17/69 (24,6%) à indicação, 8/69 (11,6%) à segurança e 4/69 (5,8%) à efetividade. Do total de pacientes 4/6 (66,6%) apresentaram hepatotoxicidade durante o acompanhamento. A situação clínica e farmacoterapêutica foi classificada como positiva para todos os pacientes. Conclusão: Houve alto número de PRM de adesão e indicação nos pacientes coinfectados. O monitoramento da efetividade e segurança dos tratamentos deve ser realizado, devido à maior susceptibilidade de reações adversas, como a hepatotoxicidade.
Helicobacter pylori. The survival strategy of a commensal symbiont in the Homo sapiens population
Authors: Avalueva E. B. , Serkova M. Yu. , Sitkin S. I.
Published: December 2021

Несмотря на крайне высокую степень инфицированности Helicobacter pylori в популяции Homo sapiens, подавляющее большинство инфицированных являются бессимптомными носителями. Широкое распространение инфекции H. pylori среди лиц без признаков патологии и низкая заболеваемость при хронической колонизации слизистой оболочки желудка указывают на то, что H. pylori с большей вероятностью является условно-патогенным микроорганизмом или патобионтом. Популяционная ликвидация инфекции H. pylori существенно снизила заболеваемость инфекцией H. pylori, однако появление устойчивости к противомикробным препаратам привело к их неэффективности.
Paradigm shift in the management of patients with H. pylori infection
Authors: Tryapyshko A. A. , Dekhnich N. N.
Published: December 2021

pylori infection is widespread throughout the world. It causes chronic progressive stomach disease and is associated with conditions such as chronic gastritis, peptic ulcer disease, atrophic gastritis, intestinal metaplasia, and gastric cancer. H. pylori-associated gastritis is an infectious disease. The main route of transmission is intra-familial. The new strategy of “screening and treating all family members” in regions with a high prevalence of H. pylori, including Russia, is cost-effective and aimed at reducing the risk of infection spreading in the population, progression of changes in the gastric mucosa and the occurrence of gastric cancer.
Damage to the musculoskeletal system during eradication therapy of Helicobacter pylori with levofloxacin
Authors: Kupriyanova I. N. , Vedensky V. A. , Valieva E. Ya. , Sinitsina M. A.
Published: December 2021

Eradication therapy is the mainstay of treatment for H. pylori-associated diseases. A case of the development of tendinitis of the left patellar ligament proper during eradication therapy using a triple regimen with levofoloxacin for 14 days for exacerbation of duodenal ulcer is presented.
Diagnostics and treatment of Helicobacter pylori infection in children
Authors: Belmer S. V. , Kornienko E. A. , Volynets G. V. , Gurova M. M. , Zvyagin A. A. , Kamalova А. A. , Luppova N. E. , Nizhevich A. A. , Novikova V. P. , Pechkurov D. V. , Privorotsky V. F. , Sataev V. U. , Tyazheva А. А. , Faizullina R. A. , Khavkin A. I.
Published: December 2021

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Modern knowledge on pathogenesis, diagnosis and treatment of helicobacter infection
Authors: Kiselev H. Yu. , Gorlenko C. L. , El-Taravi Ya. A. , Porubayeva E. E. , Budanova E. V.
Published: December 2021

Since its discovery, H. pylori infection is known as one of the risk factor for the development of gastritis, peptic ulcer, GIT tumors and numerous other diseases such as psoriasis. Infection caused by H. pylori is posed as the top oncogene in the risk of the development of gastrocarcinoma (First class oncogene by Classification of International Agency for Research of Cancer). That is why the elaboration of fast and accurate methods of diagnosis (non-invasive methods especially) and proper treatment of Helicobacter infection is still very important. Throughout the time, knowledge about pathogenesis of Helicobacter infection have been expanded with the detection of adhesins, chemotaxins and multiple virulence factors related to invasion, adhesion and cytotoxicity of H. pylori. Invasive and non-invasive methods of diagnostics are currently being improved in effectiveness and accuracy. But still, due to different factors (e. g., dramatically increasing drug resistance), eradication of H. pylori remains big problem world-wide. Our review represents modern data on pathogenesis, diagnostics and treatment of Helicobacter infection.
Study of the FUT2 gene association with infection and clinical manifestations of Helicobacter pylori infection
Authors: Klimova A. S. , Shrayner E. V. , Khavkin A. I. , Kokh N. V. , Lifshits G. I. , Zamaytina Yu. E.
Published: December 2021

The aim of the pilot study of a group of adolescents with H. pylori infection was to study the preliminary data obtained on the rs602662 locus of the FUT2 gene and to establish its role in the realization of clinical manifestations of chronic gastritis, gastric ulcer and duodenal ulcer associated with H. pylori.

Methods: The study included 91 patients. The study for the presence of the polymorphic locus rs602662 of the FUT2 gene was carried out by the standard TaqMan PCR method on a Real-Time CFX96 Touch amplifier. The duration of the study was 6 months.

Results: The main group included 25 adolescents aged 16 to 17 years 11 months, the control group included 20 patients. Patients infected with H. pylori more often noticed symptoms of dyspepsia - in 36%, compared with the control group - 9.7%. The presence of a family history in the main group for associated diseases had a significant difference, χ2 = 4.97, p <0.05.

To assess the contribution of the genotype of the rs602662 locus of the FUT2 gene to the risk of clinical manifestations in H. pylori infection, the main group was divided into subgroups. In the distribution of alleles in these groups, statistically significant differences were revealed.

Allele “A” has a protective effect against the onset of clinical symptoms of dyspepsia. The odds ratio (OR) with the carriage of allele “A” (genotypes A / A and G / A versus G / G) to have clinical symptoms with a positive H. pylori status was 0.175 (CI = [0.049-0.625] chi2 = 7.79 p = 0.0053).

Conclusion. As a result of the study, we were unable to identify a significant association of alleles and genotypes of the rs602662 locus of the FUT2 gene with clinical manifestations of H. pylori infection. At the same time, carriers of the A allele have a pronounced association with the absence of clinical symptoms in patients with a positive H. pylori infection status of 0.175 (C.I. = [0.049-0.625] chi2 = 7.79 p = 0.0053).
A mechanism of abnormal motility of the esophagus and stomach and associated sound phenomenon
Authors: Garanin A. A.
Published: December 2021

The aim of the article is to update the pathophysiological mechanisms that cause the appearance and activation of pathological peristalsis of the esophagus and stomach and associated esophageal-gastrointestinal-diaphragmatic noise, described earlier, designed to expand the diagnostic capabilities of physical methods for diagnosing hiatal hernia and to facilitate the differential diagnosis of this disease with other diseases of the chest. The result of the study is to describe 5 the pathophysiological mechanisms of developing hernia hiatal and lead to the emergence of pathological motility of the esophagus and stomach in the form of the strengthening or emergence of antiperistaltic waves. The resulting acoustic phenomenon is the essence of a new physical symptom in this disease - esophageal-gastrointestinal-diaphragmatic noise. The first mechanism that determines the pathological motor activity of the smooth muscle cells of the esophageal wall is the so-called esophageal “cleansing” peristalsis, which prevents the regurgitation of the acidic contents of the stomach into the esophagus, where the environment is normally neutral. The second mechanism that causes the appearance and strengthening of pathological peristalsis of the stomach is the deformation during the passage of its part through the esophageal opening of the diaphragm into the chest cavity. The third mechanism that determines the occurrence of pathological peristalsis of the esophagus and stomach is a violation of the secretion and metabolism of nitric oxide in diaphragmatic hernias. The fourth mechanism that leads to the appearance of esophageal-diaphragmatic noise is the pathological peristalsis of the esophagus and stomach in patients with hiatal hernia, which causes the appearance of antiperistaltic waves accompanied by gastro-esophageal reflux and manifests itself in clinically pathological belching. The fifth mechanism that causes pathological peristalsis of the esophagus is the phenomenon of hydrodynamic cavitation, which occurs as a result of regurgitation of the contents of the stomach into the esophagus. Understanding the pathophysiological mechanisms that cause the appearance of pathological peristalsis and antiperistalsis of the esophagus and stomach in patients with diaphragmatic hernia allows us to understand the causes of the sound phenomenon and the associated physical symptom in this disease.
Helicobacter pylori-associated comorbidity
Authors: Sarsenbaeva A. S.
Published: December 2021

Helicobacter pylori (H. pylori) infection is known to lead to various diseases such as gastric and duodenal ulcers, chronic gastritis and malignant diseases, including MALT lymphoma and stomach cancer. To date, various factors of pathogenicity and virulence of the H. pylori bacterium have been studied. The interaction of infection with host cells leads to the induction of inflammatory responses through the release of cytokines, activation of apoptosis or proliferation, which leads to inflammation and dysfunction of the epithelial barrier. This process can facilitate the movement of H. pylori virulence factors and inflammatory mediators into the bloodstream and promote or enhance the development of a systemic inflammatory response and the possible clinical effects of H. pylori infections outside the stomach. The purpose of this review is to clarify the available data on H. pylori-associated comorbidity with diseases of the cardiovascular, nervous, endocrine systems, autoimmune diseases and some other pathologies outside the digestive system.
Errors in the diagnosis and treatment of Helicobacter pylori infection: in anticipation of new conciliation documents
Authors: Bordin D. S.
Published: December 2021

The high prevalence of H. pylori and diseases caused by this infection determine the relevance of discussing the problems of its diagnosis and treatment on the eve of the emergence of new international and domestic agreements. Studies published in recent years, including articles on the materials of the European Registry on the management of Helicobacter pylori infection (Hp-EuReg), provide a rich background for the analysis of errors in diagnosis and treatment of this infection, and the development of approaches to optimize clinical practice.
The effect of eradication therapy on the quality of life of patients with chronic erosive gastritis induced with Helicobacter pylori
Authors: Afanasenkova T. E. , Dubskaia E. E.
Published: December 2021

The aim of the study was to evaluate the effect of eradication therapy on the quality of life of patients with chronic erosive gastritis induced with Helicobacter pylori. The quality of life was assessed according to the GIQLI questionnaire before treatment during incomplete remission, remission, and during the year. It was found that the exacerbation of the disease significantly changes the level of quality of life of patients, and the complex treatment, eradication of Helicobacter pylori, which stopped the exacerbation of the disease, gradually increases and brings this indicator closer to the control group. The gastrointestinal quality of life index can be used as an additional criterion for diagnosing the stages of chronic erosive gastritis, for evaluating the effectiveness of therapy, determining the timing of treatment, rehabilitation and prevention in the dispensary management of patients at the therapeutic site.
Eradication therapy of helicobacteriosis with probiotics, problems, and prospects
Authors: Ermolenko E. I. , Molostova A. S. , Gladyshev N. S.
Published: December 2021

Currently, there is an urgent question of optimizing the treatment of stomach diseases associated with Helicobacter pylori, due to the increasing resistance of the pathogen to antibiotics and the presence of side effects of standard therapy. To optimize it, it is proposed to use probiotics as an additional or monotherapy. The review presents the results of studies of anti-helicobacter activity by in vitro and in vivo systems, as well as an assessment of the clinical effectiveness of various probiotic strains of microorganisms in eradication therapy. Several mechanisms of action of probiotics in the treatment of HP-related diseases are discussed. The problems and prospects of using personalized therapy of helicobacteriosis with probiotics and autoprobiotics, based on strains obtained from the gastrointestinal tract, are indicated.
Morphological, ultrastructural and brightness quantitative characteristics of Helicobacter pylori electronic microscopic images
Authors: Zhukhovitsky V. G. , Navolnev S. O. , Shevlyagina N. V.
Published: December 2021

Using an original computer program, a quantitative characteristic of the structural features of the cultures of two reference strains of Helicobacter pylori, identified by transmission electron microscopy, was performed. The results obtained made it possible to establish morphological, ultrastructural and brightness differences between individual bacterial cells of the studied strains. The proposed program, compiled in accordance with the requirements of computer vision technology, makes it possible to detect differences in the structure of bacterial cells that are not detected by visual assessment, and also opens up the possibility of studying the phenotypic heterogeneity of isogenic populations of Helicobacter pylori and its pathogenic significance.
The premorbid background and the most significant predictors of the development chronic gastroduodenal pathology in children
Authors: Turdieva Sh. T.
Published: December 2021

The study features of premorbid background and the most significant predictors of the development of chronic gastroduodenal pathology in children and adolescents of school age. Materials and methods. The results of screening questioning of schoolchildren with chronic gastroduodenal pathology (CGDP) - n=286, and practically healthy schoolchildren - n=1023, from 6 to 15 years agо. The survey conducted according to the questionnaire developed by us, which includes 24 questions. The relative risk (RR) calculated using traditional statistical formulas with a confidence interval limit 95% CI (confidence interval). Results. In this study, it was found that the main nutritional reason for the development of СGDP in schoolchildren is a malnutrition - 69.2%, RR=2.25 (CI=1.81-2.79), and food for fast food - 65.0%, RR=4.19 (CI=3.45-5.09). The least observed was the abuse of spicy food - 4.9%, RR=1.24 (CI=0.80-1.91). The 42.7% of patients were constantly in a state of heightened psychoemotional stress - RR=1.6 (CI=1.32-1.93). Helicobacter pylori (HP) - infection was diagnosed in 57.7% of patients - RR=4.84 (CI=4.04-5.79), 29.0% of patients underwent acute intestinal infections - RR=2.74 (CI=2.29-3.27), and 62.3% had a history of hereditary burden of chronic diseases of the gastrointestinal tract - RR=1.65 (CI=1.34-2.02) Conclusion. The most significant predictors and premorbid backgrounds for the development of СGDP in schoolchildren are HP-infection (RR=4.84; CI=4.04-5.79; RRR=3.84), food for fast food (RR=4.19; CI=3.45-5,09; RRR=3.20) with the development of overweight and obesity (RR=3.64; CI=2.97-4.47; RRR=2.64), the presence of chronic foci of infection (RR=2.58; CI=2.05-3.23; RRR=1.58).
The role of Helicobacter pylori in metabolic and cardiovascular diseases
Authors: Kugler T. E. , Taradin G. G. , Pellicano R.
Published: December 2021

Helicobacter pylori (H. pylori) infection is one of the most common in the world. More than 50% of the world’s population is infected and infection rates are especially high in countries with poor socio-economic conditions. H. pylori causes gastroduodenal and extra-gastroduodenal diseases including such metabolic disorders as obesity, diabetes mellitus and non-alcoholic fatty liver disease. Recent epidemiological and clinical studies showed that the long-term persistence of H. pylori infection is associated with the development and progression of atherosclerosis and consequently cardiovascular diseases. However, the correlation between these conditions is ambiguous and there is not enough evidence to confirm it. The lack of consensus might be related to differences in diagnostic methods used for H. pylori and the variety of its genotypes. Considering high prevalence of H. pylori infection as well as high incidence of metabolic and cardiovascular diseases, a verified correlation between these can be of great epidemiological, prophylactic and clinical significance.
Helicobacter pylori infection reduces the risk of gastroesophageal reflux disease
Authors: Khlynova R. I. , Khromtsova O. M. , Berdnikov R. B. , Khlynov I. B.
Published: December 2021

The aim is to study the effect of Helicobacter pylori infection on risk of developing gastroesophageal reflux disease. Materials and methods - cross-sectional observational study of 1007 patients with dyspepsia syndrome who underwent videoesophagogastroduodenoscopy with biopsy and histological examination of biopsy specimens of the gastric mucosa by OLGA-system. The age, gender, overweight, cigarette smoking, presence of Helicobacter pylori infection and gastritis stage were assessed. Results - the study showed a significant decrease in the incidence of gastroesophageal reflux disease in patients with positive H. Pylori status by 4% (RR 0,68; 95% CI, 0.49-0.94, p=0,041). The risk of developing gastroesophageal reflux disease significantly higher in overweight (RR 2,62; 95% CI 2,0-3,56; р<0,001) men (RR 1,76; 95% CI 1,33-2,32; р=0,0046) who smoked cigarettes (RR 3,23; 95% CI 2,45-4,24; р<0,001) and was not associated with the patient’s age and the stage of gastritis (р>0,05). Conclusion - a significant reduction in the frequency and risk of developing gastroesophageal reflux disease in patients with Helicobacter pylori infection is demonstrated.
The Effect of Swimming Training on Adrenomedullin mRNA Levels in the Aorta, Kidney, and Adrenal Gland of L‐NAME‐induced Hypertensive Rats
Authors: Koç Yıldırım Ece , Örenlili Yaylagül Esra , Kaya Mehmet , Balkaya Muharrem , Ülger Celal , Belge Ferda , Ünsal Hümeyra , Ünsal Cengiz , Ekici Mehmet , Dedeoğlu Zahide , Ceylan Candan İlkem , Üner Aykut Göktürk
Published: December 2021

Adrenomedullin, which is produced by the vascular endothelial and smooth muscle cells and cardiomyocytes, is considered to be a local factor controlling vascular tone, cardiac contractility, and renal sodium excretion. Hypertension is the most common cause of cardiovascular disorders and diseases. Exercise has beneficial effects on hypertension, but pathophysiological factors involved in exercise‐mediated amelioration of hypertension are yet to be elucidated. We hypothesized that adrenomedullin produced through exercise could play an essential role in the protection from hypertension. For this study rats were subjected to swimming training for six weeks (1‐h per day and five times each week). Meanwhile, hypertension was induced by the oral administration of L‐NAME (60 mg/kg). Here, we show that L‐NAME administration per se leads to a significant increase in mean arterial blood pressure. Notably, the 6‐week swimming exercise causes a protective effect from the development of hypertension. In addition, the rats rescued from hypertension have high mRNA levels of renal adrenomedullin while they have low levels of adrenomedullin mRNA in the aorta. The obtained data indicate that a 6‐week exercise intervention rescues rats from high blood pressure by leading to changes in adrenomedullin levels in the aorta and kidney. The increased expression of adrenomedullin in the aorta might have been a result that compensates for the hypertensive effect of L‐NAME. On the other hand, exercise probably exerts its protective effects on hypertension by increasing adrenomedullin in the kidney. A more extended exercise period may give more apparent results regarding the level of adrenomedullin in different organs.
Effects of IPARD Programme on Animal Husbandry in Aydin
Authors: Türkyılmaz Mehmet Kenan
Published: December 2021

The first aim of this study was to investigate the utilization of IPARD financial supports controlled by Agriculture and Rural Development Support Institution (ARDSI) by county and production basis. Secondly, the assessment of these enterprises’ structural and administrative status of except industrial milk and meat processing enterprises at the enterprise level was aimed. The study was performed with data collected via questionary forms from 37 dairy, beef and broiler enterprises. It is estimated that animal producers have got 54536884.28 TL as support in IPARD‐I financial support within 9‐ 15th calls. It is calculated that milk production was the leader in total supports with 22328683.05 TL (40.9%). It is determined that Germencik and Yenipazar counties have the most significant shares, while Karpuzlu and Sultanhisar have minor investments. In terms of the number of contracts, it is calculated that the biggest share belonged to Yenipazar and Efeler counties with 10 and 9 projects, respectively. In other words, it is understood that 40% of total signed contracts came from these two counties. Consequently, in terms of the development of animal husbandry, Aydin has obtained 37 animal production and 13 animal processing facilities via seven calls by the IPARD‐I program.