bluuebunny/crossref_metadata_2025 huggingface dataset:
Aristote sur la sagesse pratique
Authors: Moss Jessica , Gévaudan Maxence , Lefebvre David
Published: August 2021

L’article porte sur le rapport entre la phronèsis (prudence ou sagesse pratique) et la vertu éthique dans la conception aristotélicienne de l’action et du bonheur. La question principale est la suivante : faut-il penser, selon une conception « humienne », que, chez Aristote, les buts sont fixés par notre désir, tandis que la raison servirait de simple instrument pour déterminer les moyens de les atteindre ? La thèse défendue est que la vertu de caractère donne bien le contenu des fins, mais cela ne conduit pas à reléguer la phronèsis au rang de simple instrument. En effet, la phronèsis est l’excellence de la délibération sur les choses en vue d’une fin. Elle nous permet de comprendre ce que signifie avoir une fin. Pour le démontrer, l’auteur examine conjointement le fonctionnement des syllogismes délibératif et démonstratif, qui sont tous deux des arguments explicatifs. Cette comparaison permet à l’auteur d’établir que la vertu éthique donne le « que » (« quoi faire »), alors que la phronèsis permet de comprendre le « pourquoi », c’est-à-dire en vue de quelle fin l’action doit être accomplie. La vertu complète suppose de saisir le « pourquoi » ; c’est pourquoi la phronèsis a une importance éthique et est nécessaire au bonheur.
On optimal stochastic jumps in multi server queue with impatient customers via stochastic control
Authors: Delavarkhalafi Ali
Published: August 2021

In this paper, a queuing system as multi server queue, in which customers have a deadline and they request service from a random number of identical severs, is considered. Indeed there are stochastic jumps, in which the time intervals between successive jumps are independent and exponentially distributed. These jumps will be occurred due to a new arrival or situation change of servers. Therefore the queuing system can be controlled by restricting arrivals as well as rate of service for obtaining optimal stochastic jumps. Our model consists of a single queue with infinity capacity and multi server for a Poisson arrival process. This processes contains deterministic rate \begin{document}$ \lambda(t) $\end{document} and exponential service processes with \begin{document}$ \mu $\end{document} rate. In this case relevant customers have exponential deadlines until beginning of their service. Our contribution is to extend the Ittimakin and Kao's results to queueing system with impatient customers. We also formulate the aforementioned problem with complete information as a stochastic optimal control. This optimal control law is found through dynamic programming.
Neurosurgery and artificial intelligence
Authors: Mofatteh Mohammad ,   Sir William Dunn School of Pathology, Medical Sciences Division, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom,   Lincoln College, University of Oxford, Turl Street, Oxford OX1 3DR, United Kingdom
Published: August 2021

Neurosurgeons receive extensive and lengthy training to equip themselves with various technical skills, and neurosurgery require a great deal of pre-, intra- and postoperative clinical data collection, decision making, care and recovery. The last decade has seen a significant increase in the importance of artificial intelligence (AI) in neurosurgery. AI can provide a great promise in neurosurgery by complementing neurosurgeons' skills to provide the best possible interventional and noninterventional care for patients by enhancing diagnostic and prognostic outcomes in clinical treatment and help neurosurgeons with decision making during surgical interventions to improve patient outcomes. Furthermore, AI is playing a pivotal role in the production, processing and storage of clinical and experimental data. AI usage in neurosurgery can also reduce the costs associated with surgical care and provide high-quality healthcare to a broader population. Additionally, AI and neurosurgery can build a symbiotic relationship where AI helps to push the boundaries of neurosurgery, and neurosurgery can help AI to develop better and more robust algorithms. This review explores the role of AI in interventional and noninterventional aspects of neurosurgery during pre-, intra- and postoperative care, such as diagnosis, clinical decision making, surgical operation, prognosis, data acquisition, and research within the neurosurgical arena.
Discurso feminista colombiano preilustrado: la imagen femenina en la vida de Sor Francisca de la Concepción
Authors: Fernández Martín Patricia
Published: August 2021

El objetivo del presente trabajo es demostrar la existencia de un discurso feminista anterior al feminismo euro-norteamericano ilustrado, para defender que la ideología patriarcal dominante ha contado siempre con una ideología feminista dominada que, por diversos motivos, no podía hacerse presente de forma explícita en los discursos de las mujeres, especialmente de las religiosas. Para ello, dividimos el texto en tres partes: en la primera ofrecemos ciertas cuestiones teóricas centradas en los estereotipos femeninos defendidos por el patriarcado durante siglos y en el concepto de “ideología” de Verschueren , de donde se puede desprender el de “ideología de género”; en la segunda parte analizamos el papel de las mujeres en la autobiografía de Francisca Josefa de Castillo; y en la tercera ofrecemos una serie de interpretaciones de su discurso que intentan crear vínculos con el contexto sociocultural en que se desarrolló su vida y su obra. La principal conclusión defiende que, mediante un fenómeno lingüístico que se puede llamar “etiquetación dinámica por proximidad emocional”, emplea un criterio de clasificación de las mujeres basado en la confianza, siempre cambiante, que le sirve para tomar decisiones en el futuro, pero que en ningún modo impone con motivos excluyentes.
O marxismo cultural no Brasil: origens e desdobramentos de uma teoria conservadora
Authors: Da Silva Wellington Teodoro , Sugamosto Alexandre , Irigaray Araujo Uriel
Published: August 2021

O presente artigo discute a narrativa sobre o suposto “marxismo cultural” e suas implicações no cenário brasileiro. Por meio da exposição das origens do termo no ambiente intelectual do neoconservadorismo estadunidense, o texto traz à baila as críticas teóricas feitas ao “marxismo cultural”. Valendo-se de autores de diversas ramificações intelectuais, o artigo elucida os pontos de contato entre o neoconservadorismo estadunidense e sua vertente brasileira. Expõe, ainda, o trabalho jornalístico e propagandístico dos ideólogos da teoria no Brasil, com destaque para o meio católico, e suas ligações com figuras centrais da administração nacional, bem como a influência da teoria na formulação de políticas públicas. O artigo se encerra com o entendimento de que embora a teoria do “marxismo cultural” seja epistemologicamente confusa, ela possui densidade semântica na medida em que impulsiona determinados projetos de poder.
La religiosidad popular de América Latina: una bisagra para colocar lived religion en proyectos de descolonización
Authors: De La Torre Renée
Published: August 2021

Este artículo busca responder la pregunta, ¿qué ganamos o perdemos usando el concepto de religiosidad popular o el de lived religion? En América Latina se ha desarrollado una tradición de estudio de la religiosidad bajo el concepto de religión popular, término de carácter polisémico. Por un lado, inscrito en un campo lingüístico en el que el catolicentrismo lo cargó de significados de descalificación y degradación, pero también ha sido soporte de significados políticos y utópicos derivados de la teología de la liberación. Incluso, investigadores recientes consideran la religiosidad popular como un rasgo regional para entender la propia lógica para transitar a la(s) modernidad(es). Por otro lado, el concepto y la metodología de lived religion (religiosidad vivida) –que busca detectar la experiencia religiosa desde la perspectiva de los individuos– ha venido ganando reconocimiento no solo en el mundo anglosajón, sino también en América Latina. En este ensayo se propone una lectura crítica para reconocer la necesidad de extender puentes entre lived religion y religiosidad popular, a fin de inscribir el reconocimiento de la experiencia religiosa en las tramas históricas que permiten colocar el conocimiento en un pensamiento de crítica poscolonial.
The Role of Dietary Potassium and Sodium in Hypertension and Cardiovascular Damage and Protection
Authors: Wang Qing
Published: August 2021

This review focuses on the role of dietary potassium and sodium in hypertension and cardiovascular (CV) damage and protection. It briefly describes the burden of global hypertension and CV diseases; discusses some of the ways that sodium and potassium imbalance induce hypertension; provides some experimental evidence explaining how high-sodium and low-potassium diet induces target organ (kidney and heart, etc.) damage independent of blood pressure, and addresses the role that a low-sodium and high-potassium diet may play to reduce the incidence of hypertension, CV events, and death.
Report of Three Bengali Cases with Hemoglobin E Variant in Najran
Authors: Khalil Mohamed Samir M. , Al-Qahtani Awad M. , AlQahtani Jobran M. , El Khawanky Mohamed Mahmoud
Published: August 2021

INTRODUCTION:

Differential diagnosis of hemoglobin (Hb) variants eluting in the A2 window on high-performance liquid chromatography (HPLC) is of particular importance. Of particular importance is Hb E, which is the most common and the most significant variant. The aim of this study was to study a rare variant infrequently seen in our countries during the routine work.

METHODS:

Sixteen Bengali workers at Najran University Hospital, Saudi Arabia, came to the laboratory for routine investigation. CBC, routine blood chemistry, and Hb separation by HPLC were performed.

RESULTS:

Three cases out of 16 showed an abnormal Hb peaked on the A2 window on HPLC consistent with the diagnosis of Hb E. Two of them had Hb E of 29.1% of each. The third case had Hb E around 86%. In addition, one case was consistent with β thalassemia trait had increased Hb A2 of 5.7%. Five cases were borderline.

CONCLUSION:

HbE could be adequately differentiated from other Hb variants eluting in the A2 window on HPLC by the percentage of the variant, its retention time, the mild clinical presentation, and the ethnic origin of the patient.
Tobacco Related Oral Lesions in South Indian Industrial Workers
Authors: Kommalapati Radhika Kalyani , Rajendra Arvind Babu Santosh , Kattappagari Kiran Kumar , Kantheti Lalith Prakash Chandra , Poosarla Chandrashekar , Baddam Venkat Ramana Reddy
Published: August 2021

Introduction:

Tobacco is the leading causative factor for both oral potentially malignant disorders and oral cancer. Tobacco use is higher among lower income population. Low-income population of India are majorly employed as industrial workers. The aim of this study is to estimate the prevalence of oral lesions associated with tobacco related habits among industrial workers.

Materials and Methods:

Cross-sectional epidemiological investigation was conducted among 1000 industrial workers using simple random sampling technique. Information on patient demographics, tobacco related (smoke and smokeless) and other deleterious habits, and clinical examination details were recorded in a structured format. The data were analyzed using Statistical Package for Social Sciences version 20.0. Results were tabulated using frequency distribution and mean with a standard deviation. Multiple logistical regression was used to analyze oral lesions by different variables.

Results:

Among the 1000 industrial workers screened, smoking habit was observed in 13.20%, while 86.8% were using smokeless tobacco. The prevalence of tobacco related oral lesions among individuals with smoke/smokeless tobacco habit was 13.8%. The study documented tobacco related oral lesions such as leukoplakia (6.5%), oral submucous fibrosis (2%), smoker’s palate (2.7%), tobacco related pigmentation (1.9%), erythroplakia (0.3%), and oral squamous cell carcinoma (0.2%).

Conclusion:

The study documented potentially malignant disorders and oral cancer among users with tobacco related habits. The results also revealed that higher prevalence of potentially malignant disorders over oral cancer. Thus, preventive programs for early detection of oral precancer and oral cancer such as tobacco cessation, tobacco counselling programs are emphasized for industrial workers.
Cytotoxicity of Silorane and Methacrylate based Dental Composites on Human Pulp Cells
Authors: Madhyastha Prashanthi S. , Bhat Kumar M.R. , Padma Divya , Bangera Madhu Keshava , Naik Dilip G. , Srikant N. , Kotian Ravindra
Published: August 2021

Introduction:

The ingredients from the dental restoratives are known to leach and elicit a host response. The prerequisite to deem a material biocompatible requires its toxicologic evaluation. The study was performed to analyze the probable toxicity resulting from silorane-based composite (SBC) with methacrylate-based composite (MBC).

Materials and Methods:

The in vitro cytotoxicity test, methyl thiazolyl tetrazolium (MTT) assay, evaluated the cell viability and proliferation rate of dental pulp cells (DPCs). The extirpated pulp was cultured in α-MEM-containing supplements and incubated at 37°C. DPCs were subjected to varying doses of SBC or MBC at different time intervals after attaining confluence and monitored for proliferation and viability via MTT assay. An independent Student t test was performed to compare the effect of composites on the DPC. The cytotoxicity levels were compared using one-way analysis of variance and posthoc Tukey multiple comparison test at 5% level of significance and P-value of <0.05.

Results:

DPC exposed to MBC showed higher viability than SBC. The MTT assay reported the number of viable cells as (>90%) in the first 24 hours. The count significantly reduced by the end of 48 hours (minimum 65% in 25 μg/ml) at all concentrations (P < 0.05). SBC had lower survival than MBC in all concentrations and periods. Except at 5 μg/ml concentration at 48 hours in SBC, no statistically significant values were reported.

Conclusion:

DPCs are prone to the cytotoxicity caused by dental composite. In contrast to MBC, the cytotoxicity of SBC declines overtime.
Knowledge, attitudes, and practices about COVID-19 among Kashmiri population
Authors: Imtiyaz Bushra Syed , Jamwal Chahat , Hussain Arshad , Roub Fazle , Tariq Rabbanie , Qayoom Imran , Syed Juvaria , Renzu Mahvish
Published: August 2021

Background:

Nations across the globe are investing enormous resources to contain the coronavirus disease 2019 (COVID-19) pandemic. Assessing community knowledge and behavior could help in designing effective health-care policies tailored to the need of target population.

Aims:

We aimed to assess the knowledge, attitudes, and practices (KAP) about COVID-19 among Kashmiri population and to determine the association of KAP scores with the sociodemographic variables.

Settings and Design:

This was a cross-sectional study conducted via various online platforms.

Materials and Methods:

A structured questionnaire was formulated which was divided into three scoring sections assessing KAP about COVID-19 and a nonscoring section assessing individual reactions. A link to the survey was disseminated through social media platforms. A total of 1051 individuals participated.

Statistical Analysis:

Descriptive statistics were used for assessing the demographic characteristics of participants. Inferential statistics (Mann–Whitney U-test and Kruskal–Wallis test) were used for comparison.

Results:

Majority of the participants belonged to the age group of 20–39 years (75.4%), were unmarried (66.6%), were from urban background (54.9%), and had education of above high school (96.3%). In general, scores suggested that participants possessed adequate knowledge (mean ± standard deviation: 10.07 ± 1.134), had good attitudes (11.85 ± 1.42), and followed good practices (12.26 ± 1.42) regarding COVID-19. However, we found the correlations between KAP scores to be weak.

Conclusions:

A knowledge–praxis gap was highlighted in the studied population which was especially true for the vulnerable age group of > 60 years. The findings call for attention of health-care policymakers to design need-based, locally adaptable, and practicable interventional strategies for target population.
Proto-oncogene Pokemon in thyroid cancer: a potential promoter of tumorigenesis in papillary thyroid carcinoma
Authors: Chang Kyungseek , Do Sung-Im , Kim Kyungeun , Chae Seoung Wan , Do In-gu , Lee Hyun Joo , Kim Dong Hoon , Sohn Jin Hee
Published: August 2021

Background: Pokemon is an oncogenic transcription regulator that plays a critical role in cellular differentiation. Although it has been found to be overexpressed in several types of cancer involving different organs, its role in thyroid gland has yet to be reported. The objective of this study was to evaluate the expression of Pokemon in papillary thyroid carcinoma (PTC) based on clinicopathological parameters.Methods: Tissue microarray samples derived from patients with PTC or benign thyroid disease were used to evaluate Pokemon expression based on immunohistochemical analysis. Correlations of its expression with various clinicopathological parameters were then analyzed.Results: Pokemon expression was observed in 22.0% of thyroid follicular cells from the normal group, 44.0% from the group with benign thyroid diseases, and 92.1% from the group with PTC (p < .001). The intensity of Pokemon expression was markedly higher in the PTC group. Pokemon expression level and PTC tumor size showed an inverse correlation. T1a tumors showed strong expression levels of Pokemon. However, larger tumors showed weak expression (p = .006).Conclusions: Pokemon expression is associated with tumorigenesis of PTC, with expression showing an inverse correlation with PTC tumor size. This might be related to the negative regulation of aerobic glycolysis by Pokemon.
Competition law post-Brexit
Authors: Scott Jonathan
Published: August 2021

The end of the Transition Period following the UK's exit from the European Union and COVID-19 are major catalysts for the Competition and Markets Authority's future work, including in the fields of merger control and antitrust enforcement. This article considers how these, and other events, will influence the CMA's work, including the establishment of the Digital Markets Unit and the Office for the Internal Market, enforcement priorities and international cooperation.
Competition in digital advertising markets
Authors: Thornton Simeon , Jenkins Chris , Husunu Marie-Madeleine
Published: August 2021

Digital advertising, both display advertising and search advertising, represents a very important part of the overall advertising market in the United Kingdom. Google and Facebook have a high degree of market power in search and display advertising, respectively. On 1 July 2020, the Competition and Markets Authority published its Final Report on its market study into online platforms and digital advertising, in which it looked in some depth at digital advertising markets, assessing whether a lack of transparency, conflicts of interest, and the leveraging of market power undermine competition in digital advertising. This article examines the issues considered by, and the findings of, the CMA in its Market Study and set out in its Final Report, and describes the policy options identified in the Market Study for promoting competition and other policy goals, such as data protection and privacy and ensuring the viability of news publishers, in digital advertising markets.
Data: how it affects competitive dynamics, how to value it, and whether to provide third-party access to it
Authors: Antuca Andreea , Noble Robin
Published: August 2021

There has been a data revolution: the combination of sensors, processing power and mobile communications means that there is more of it, and it is having a greater impact on our lives than ever before. Across the world, there have recently been many new initiatives and legislative proposals for opening up access to some of that data. This is often driven by two different motivations: the desire to create new positive outcomes with existing resources, and the desire to correct negative impacts on competition in markets. To regulate data access properly, it is necessary to understand what makes data different and what its value is. If data access is going to be mandated, how can one value the data that a business holds, and set fair and reasonable charges for access to it? Economic tools that analyse the cost of creating the data, and the benefits derived from it, provide critical insight into this question.
An Exploratory Study of Business to Business (B2B) Brand Sensitivity - How do brands influence a German hospital’s buying decision-making process.
Authors:   , Kaminski Kristin
Published: August 2021

Historically branding was seen as having limited significance for organisations in industrial markets (Saunders & Watt, 1979). Research in the 1990s began to challenge this earlier view and delivered evidence of B2B’s branding relevance (Leek & Christodoulides, 2012; Veloutsou & Taylor, 2012) but still there is a lack of understanding when brands are the most significant in the context of B2B (Zablah, Brown, & Donthu, 2010). The researcher set out to investigate the B2B brand sensitivity in buying units of German hospitals. This required two prime investigations and analysis, to gain knowledge of the factors influencing brand sensitivity when buying medical devices. The researcher approached the investigation from a constructivist paradigm perspective and decided that a sector level case study approach of German hospitals was the most suitable method in order to explore in depth different aspects of the process and to get a comprehensive view of the situation (Yin, 2013). To gain ‘outsider’ research, qualitative semi-structured interviews have been the research method adopted, in order to understand why and how the situation occurred (Guba & Lincoln, 2005). The thesis highlights the role of brands in the context of organisational buying and provides guidance when brand sensitivity is present. In addition, B2B branding theory is enhanced and the managerial implications for managers in the medical device industry have been developed. The key findings of the thesis include the different participants in the buying unit of a German hospital and the influence factors for buying centre composition. Furthermore, the key findings show the factors that influence the decision making of a German hospital, and the parameters that have an influence on brand sensitivity are displayed. It is recommended to invest in branding strategies if the respective purchase decision is characterized by such a situation or the outlined brand values are required.
Design of a Power-Efficient Low Complexity Non Maximally Coefficient Symmetry Multi Rate Filter Bank for Wideband Channelization
Authors: Vaidya Kirti Samir , Dethe C. G. , Akojwar S. G.
Published: August 2021

A solution for existing and upcoming wireless communication standards is a software-defined radio (SDR) that extracts the desired radio channel. Channelizer is supposed to be the computationally complex part of SDR. In multi-standard wireless communication, the Software Radio Channelizer is often used to extract individual channels from a wideband input signal. Despite the effective channelizer design that reduces computing complexity, delay and power consumption remain a problem. Thus, to promote the effectiveness of the channelizer, we have provided the Non-Maximally Coefficient Symmetry Multirate Filter Bank. In this paper, to improve the hardware efficiency and functionality of the proposed schemes, we propose a polyphase decomposition and coefficient symmetry incorporated into the Non-Maximally Coefficient Symmetry Multirate Filter Bank. For sharp wideband channelizers, the proposed methods are suitable. Furthermore, polyphase decomposition filter and coefficient symmetry is incorporated into the Non-Maximally Coefficient Symmetry Multirate Filter Bank to improve the hardware efficiency, power efficient, flexibility, reduce hardware size and functionality of the proposed methods. To prove the complexity enhancement of the proposed system, the design to be the communication standard for complexity comparison.
De-radicalization Program: The Case Study of Indonesia
Authors: Ulyana Yaza Azzahara , Riyansyah Ahmad
Published: August 2021

Deradicalization program has emerged since 2012 by Indonesian Government due to the fact of increasing number of terrorism act happened in Indonesia. Indonesian government imposed the soft approach in order to be able to rehabilitate terrorist, its group, and family from radical mindset effectively. The ex-convicted terrorist is expected to disengage from their previous group and mindset and ready to rejuvenate as a new person with a moderate mind so that they can mingle back to the society. The program that applied by BNPT is comprehensively for all ages the only differences is when encountered the youth so the approach is slightly different. The purpose of this study is to describe and explaining the formulation of Indonesian deradicalization program in detail. This study uses a social identity theory in explaining the formulation and implementation of BNPT de-radicalization program. In this study, the author used qualitative methods with explanatory research type, followed by collecting data through literature. Based on existing findings, the deradicalization program, which rooted in social identity basic assumptions, is comprehensively established without discrediting certain religious values. And the de-radicalization program in Indonesia can be regarded as successful if the number of people turning back to the radical acts is low. So that to create a sustainable effort BNPT should promote the program more harmoniously, to ensure the effectiveness of the rehabilitation program.
Competition Strategy in the Islamic Banking Industry: An Empirical Review
Authors: Rahmayati Rahmayati
Published: August 2021

The research purpose to understand about Islamic banking industry competition in the marketing. The research method is used in the form of library research which collecting data by using written materials. The competition demands Islamic banking to be more aggressive than before to apply marketing strategic especially during Covid-19 pandemic. The government give recommendation and instruction that Islamic banking is demanded to serve customer by digitization of bank service. Islamic banking can reach a wider market. Acceleration of technology driven business model has to be a main priority during and pasca Covid-19 pandemic. The study found that the competition strategy in the Islamic banking Industry adopted by the marketing value is having a significant impact on to serve customer by digitization of bank service.
Literatürde Olmayan Bir Tabloda Ming Halısı ve Ming Halıları
Authors: UĞURLU Servet Senem
Published: August 2021

14.-15. yüzyıllarda Anadolu’da dokunmuş hayvan motifli halılar, birçok araştırmacının dikkatini çekmektedir. Bu dönemde Anadolu’da farklı motifler ve desen kompozisyonlarında oluşturulmuş halılar dokunmuştur. Halı ortalarındaki desen kompozisyonları; kare, eşkenar dörtgen, sekizgen, üçgen gibi belirli geometrik şekillerle oluşturulmuştur. Bölümler içinde stilize edilmiş sembolik halde mitolojik değerler taşıyan hayvan motifleri kullanılmıştır. Dört yöne ihraç edildiği bilinen hayvan motifli Anadolu halıları, Batı sanatında ve öncelikle İtalyan ressamların tablolarında 14. yüzyıl başından itibaren görülmektedir. Bu halılar özellikle Sienalı ve Floransalı ressamların tablolarında resimlenmiştir. 14. yüzyıl sonu-15. yüzyıl Anadolu halıları arasında öne çıkan önemli, ünlü ve karakteristik özellikler içeren halılar vardır. En ünlüsü Wilhelm von Bode tarafından Berlin İslam Eserleri Müzesi’ne satın alınan Ejderha ve Anka kuşu motifli halı’dır. Bu halı, Anadolu Beylikleri Dönemi hayvan motifli halıları içinde en iyi korunmuş tek örnektir. 1905 yılında Martin’in Konya’daki Alaeddin Camisinde 13. yüzyıl Selçuklu halılarını keşfine kadar, Ming halısı dünyanın en eski halısı olarak tanıtılmıştır. Kurt Erdmann, Batılı ressamların tablolarındaki halı tasvirlerinden yararlanarak halıların tarihlerinin belirleneceğini öne sürmüş, Wilhelm von Bode İtalya’dan satın aldığı Ming halısının tarihini bu yöntemle bulmuştur. Bu halı, ilk önce Bode halısı, daha sonrasında ise Ming halısı olarak isimlendirilmiştir. Bu araştırmada, Ming halısı yeni bilgilerle incelenerek tipolojik ve ikonografik olarak açıklanacaktır.
A preliminary study of possible fibrotic role of meprin metalloproteases in scleroderma patients
Authors: Koçak Ayşe , Köken Avşar Aydan , Harmancı Duygu , Akdoğan Gül , Birlik A. Merih
Published: August 2021

Objectives: This study aims to investigate the possible fibrotic role of meprin metalloproteases and possible fibrotic effects of activator protein-1 (AP-1) in scleroderma patients.

Patients and methods: Between April 2018 and April 2019, a total of 85 scleroderma patients (9 males, 76 females; mean age: 54.9 years; range, 22 to 80 years) who met the 2013 American College of Rheumatology/European League Against Rheumatism criteria and 80 healthy control individuals (10 males, 70 females; mean age 42.9 years; range, 19 to 65 years) were included. Patients’ data and blood samples were collected. Messenger ribonucleic acid expressions of interleukin (IL)-6, AP-1 subunits, and tumor necrosis factor-alpha (TNF-α) were analyzed by quantitative real-time polymerase chain reaction. Serum meprin alpha and beta protein levels were analyzed using the enzyme-linked immunosorbent assay.

Results: Meprin alpha and meprin beta protein levels increased in scleroderma patients. The AP-1 subunits (c-Fos, c-Jun), IL-6, and TNF-α increased in scleroderma patients, compared to controls.

Conclusion: Our results provide evidence showing that increased meprins levels may be related to AP-1 levels and increased meprins levels may responsible for increased inflammatory TNF-α and IL-6 levels. All these data suggest meprins as promising therapeutic targets to restore the balance between inflammation and extracellular matrix deposition in scleroderma.
Screening and identification of potential biomarkers and therapeutic targets for systemic sclerosis-associated interstitial lung disease
Authors: Huang Biqing , Li Jing , Zhao Jiuliang
Published: August 2021

Objectives: This study aims to analyze gene expression in lung tissue and lung fibroblasts of patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD) to identify potential biomarkers and therapeutic targets and to examine its possible role in the pathogenesis of SSc-ILD.

Patients and methods: We obtained datasets from Gene Expression Omnibus (GEO) database, and used Robust Rank Aggregation to calculate the co-expressed differentially-expressed-genes (DEGs) in three chips, then analyzed the function, signaling pathways and the protein-protein interaction network of the DEGs. Finally, we verified the DEGs related to SSc-ILD by three databases of Comparative Toxicogenomics Database (CTD), GENE, and DisGeNET, respectively.

Results: There were 16 co-expressed DEGs related to SSc-ILD in three GEO series, of which six genes were upregulated, and 10 genes were downregulated. The CTD included 29,936 genes related to SSc, and the GENE and DisGeNET databases had 429 genes related to SSc.

Conclusion: The results of gene differential expression analysis suggest that interleukin-6, chemokine ligand 2, intercellular adhesion molecule 1, tumor necrosis factor alpha-induced protein 3, pentraxin 3, and cartilage oligomeric matrix protein may be implicated in the pathogenesis of SSc-ILD and are expected to be potential biomarkers and therapeutic targets for SSc-ILD.
Administration of the educational process (legal and linguistic-didactic aspects) in the conditions of quarantine and post-quarantine measures caused by covid-19
Authors: Mizetska Vira , Sierykh Olena , Savchuk Hanna , Yevtimova Diana , Synieokyi Oleh
Published: August 2021

The aim of the study is to characterize the impact of the COVID-19 pandemic on the administration of the educational process on the examples of legal and linguistic-didactic aspects. The object of the study is systemic and functional changes in science and education under the influence of the COVID-19 pandemic. The subject of the study is public relations in the field of education and science in their legal and linguistic-didactic aspect under the influence of the COVID-19 pandemic. Research methods are general scientific and special scientific methods, in particular, system-structural, formal-legal, hermeneutic; methods of analysis, synthesis. As a result of the research, the peculiarities of administration of educational processes in the conditions of COVID-19 in the aspect of mechanisms of legal support of activity of bodies of education and science, linguodidactics were formulated; the characteristic of systemic changes in the sphere of education which have occurred under the influence of the distribution of a coronavirus is carried out; describe the main approaches contained in the current scientific literature to solve the above problems.
Mitologización del espacio interior del Cáucaso Norte y folclore
Authors: Sautieva Fatima B. , Radzhabov Ismail M. , Karabulatova Irina S. , Pakhomenkova Olesia Mikhailovna
Published: August 2021

La civilización electrónica moderna actualiza la esfera de la mitología y el folclore para cambiar la imagen tradicional interna del mundo. Los autores consideran cómo la imagen tradicional del mundo de la sociedad patriarcal del Cáucaso del Norte afecta la percepción mitologizada del espacio y la conciencia del propio lugar en el nuevo mundo mitologizado. Los autores consideran el sistema de educación estética en el Cáucaso (en el ejemplo de Ingushetia) como una herramienta eficaz para preservar la identidad étnica y sociocultural en un entorno agresivo de influencia digital. Los autores analizan cómo los escolares ingush modernos perciben las características de los héroes mitologizados de la epopeya Nart. Los autores describen qué características de los héroes épicos de la epopeya caucásica son deseables y preferidas para la generación más joven de la región. Esto nos permite confirmar nuestra hipótesis sobre la presencia de una base común entre los pueblos del Cáucaso, que ha recibido un desarrollo independiente en cada una de las culturas originarias. Este artículo ilustra la primera experiencia de análisis sobre el estudio de la mitologización del espacio interior de una persona en un curso escolar sobre folclore de los pueblos del Cáucaso, utilizando el ejemplo de la cultura popular ingush.
IN-SITU SYNTHESIS OF 3D-PRINTED MAGNETIC NANOPARTICLES EMBEDDED PHOTOPOLYMERS
Authors: SARAÇ Mehmet Fahri
Published: August 2021

In order to enhance magnetic and thermal properties of polymeric structures in 3D (three-dimensional) form, stereolithography technique is an alternative way to in-situ synthesize magnetic nanoparticles such as iron, cobalt and nickel in photocurable resin during laser photopolymerization for magnetic micromachines. By using different types of magnetic nanoparticles in the resin, the formed structure exhibits different mechanical, thermal and magnetic behaviors.In this study, magnetic nanoparticles were synthesized by laser irradiation to investigate the effects of the magnetic nanoparticles in 3D structure. Under constant metal salt amount and forming layer thickness, morphological, characterization, mechanical, thermal and magnetic properties were conducted by scanning electron microscope (SEM), transmission electron microscope (TEM), tensile test, thermal gravimetric analysis (TGA), differential scanning calorimetry (DSC) and vibrating sample magnetometer (VSM), respectively. As a result, it observed that the magnetic properties of iron-based polymeric structures show higher saturation magnetization (0.0145 emu/gr) while thermal stability remains low for other magnetic embedded polymer samples. In the presence of magnetic nanoparticles, its mechanical strength decreased from 14 MPa to 5 MPa for all experiments against pure 3D resin, as well as it leads to more fragile structures. Finally, for each sample, singular magnetic nanoparticles were formed in the polymer matrix and verified that nanoparticles are completely reduced.
A Translation of Al-Fuzai’s “Resolution”
Authors: Dohal Gassim H.
Published: August 2021

Khalil I. Al-Fuzai (1940) is an Arab writer who wrote and published few collections of stories. In his stories, he depicts Arabian society in a simple, clear, and direct way (Dohal 2013). “Resolution” is one of his stories which addresses social issues. I translated this story because it represents a good sample of Al-Fuzai’s literary writing (Dohal 2021 & 2019), telling how a man could be treated at his old age by his children.
SUPPORTING THE SPECIAL EDUCATION UNIT SYSTEM IN PROMOTING INCLUSIVE EDUCATION
Authors: Ketheeswaran K.
Published: August 2021

This study was conducted to investigate the practice of the Special Education Unit (SEU) system in regular schools and its way forward to support the Inclusive Education (IE) system in the Ampara District. A survey design and qualitative and quantitative approaches were followed to conduct this study. The questionnaire, interview, and focus group discussion were utilized to collect data. 27 schools with Special Educational Needs (SENs) and participants were purposively selected. Data was collected from 27 school principals, 86 teachers from SEUs, seven In-Service Advisers of Special Education (ISA SE), and 35 parents of students with SEN. SPSS-16 was utilized for quantitative data analysis and the content analysis utilized qualitative data. The findings show that SEUs have been in practice since 2002 with the collaboration of the stakeholders, and it supports the improvement of IE practices in schools. Further, the study recommends that educational administrators should be allocated adequate resources and follow a mechanism to improve IE practices.

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Revistas científicas de las universidades nacionales de la Región Cajamarca
Authors: Rios-Campos Carlos , Macias Patricia Mercedes Tapia , Gómez Oscar Efrén Anchundia , Moya Gina Elizabeth Mera , Vilchez Shirley Tatiana Bustamante , Gómez Jannyna Reto , Trujillo Jury Yesenia Aquino , Campos Pilar del Rosario Rios
Published: August 2021

RESUMEN

Las universidades nacionales peruanas, en especial del interior del país, están dirigiendo sus esfuerzos en difundir los nuevos conocimientos mediante sus revistas científicas indexadas. Se planteó el objetivo general, análizar las revistas científicas de las universidades nacionales de la Región Cajamarca. Los objetivos específicos, identificar el cumplimiento de las características de la metodología Latindex, por parte de las revistas científicas y formular recomendaciones en la gestión de las mismas.Se ha empleando la metodología de Latindex, con sus 38 características de calidad del Catálogo 2.0. Resultados, las tres revistas científicas cumplen con más de 30 características de la metodología de Latindex. Conclusiones, las revistas científicas de la UNC y UNJ han logrado su indexación en Latindex, mientras que de la UNACH no tiene indexación alguna, por lo que su visibilidad es mínima. Se recomienda minimizar los índices de endogamia editorial y autoría de las revistas científicas de las universidades nacionales de la Región Cajamarca. Además, se debe indicar las políticas de acceso y reuso, detección de plagio, uso de estadísticas y políticas de preservación digital.

 

ABSTRACT

Peruvian national universities, especially in the interior of the country, are directing their efforts to disseminate new knowledge through their indexed scientific journals. The general objective was set, to analyze the scientific journals of the national universities of the Cajamarca Region. The specific objectives, to identify the fulfillment of the characteristics of the Latindex methodology, by the scientific journals and to formulate recommendations in their management. The Latindex methodology has been used, with its 38 quality characteristics of the Catalog 2.0. Results, the three scientific journals comply with more than 30 characteristics of the Latindex methodology. Conclusions, the scientific journals of the UNC and UNJ have achieved their indexation in Latindex, while the UNACH has no indexing whatsoever, so its visibility is minimal. It is recommended to minimize the rates of editorial inbreeding and authorship of the scientific journals of the national universities of the Cajamarca Region. In addition, access and reuse policies, plagiarism detection, use of statistics and digital preservation policies must be indicated.
Aplicación de apoyo para jóvenes universitarios con trastorno de ansiedad generalizada
Authors: Morales Blanca Leticia Guerra , Andrade Mauricio Ricardo Melchor , Aguilar Diego Ulises Martínez , Ortiz Octavio Salud Ortiz
Published: August 2021

RESUMEN

Según datos de la última Encuesta Nacional de Epidemiología Psiquiátrica, la ansiedad afecta a 14.3% de la población (2018). El trastorno de ansiedad generalizada se desarrolla lentamente, y suele iniciar en la adolescencia o poco tiempo después de ésta. La finalidad del proyecto es proporcionar ayuda a jóvenes que sufren ataques de ansiedad y encontrar alguna alternativa para controlar dicho trastorno. El producto es una aplicación de software con diversos recursos, como lo son imágenes, videos y audios, que serán seleccionados de acuerdo a un test inicial con el que se pretende obtener una manera óptima de afrontar los ataques de ansiedad. Se busca que la aplicación sea accesible y esté siempre su material disponible en el celular (independientemente de si la persona tiene acceso a la red o no), el cual deberá contar con al menos Android 6. No se pretende reemplazar al especialista, sino acompañar a la persona en su proceso de reincorporación a una vida normal por medio de la reestructuración cognitiva, la cual se refiere al entrenamiento del cerebro para que aquello que hace que la ansiedad y sus molestos síntomas disminuya.

 

ABSTRACT

According to data from the latest National Psychiatric Epidemiology Survey, anxiety affects 14.3% of the population (2018). Generalized anxiety disorder develops slowly, usually starting in adolescence or shortly after adolescence. The aim of the project is to provide help to young people suffering from anxiety attacks and to find some alternative to control such disorder. The product is a software application with various resources, such as images, videos and audios, which will be selected according to an initial test with which it is intended to obtain an optimal way to deal with anxiety attacks. The application is intended to be accessible and its material is always available on the cell phone (regardless of whether the person has access to the network or not), which must have at least Android 6. It is not intended to replace the specialist, but to accompany the person in the process of reincorporation to a normal life through cognitive restructuring, which refers to the training of the brain so that what makes anxiety and its annoying symptoms diminish.
Necesidad de incluir la política ambiental en los diseños curriculares universitarios
Authors: Estrada Ortiz Irma Rosario
Published: August 2021

El presente artículo tiene su origen en el trabajo de tesis “La observancia de la Política Ambiental en la Educación Universitaria”, el cual, en la actualidad se está desarrollando, a fin de poder establecer si la Política Ambiental de la Universidad de San Carlos de Guatemala, la cual fue aprobada en fecha 30 de junio 2014 mediante acta 13-2014, punto sexto, inciso 6.2 por el Consejo Superior Universitario, se encuentra incluida en el Diseño Curricular de la Licenciatura en Psicología, ya que, se considera indispensable incluirla con lo cual se busca una formación holística de los estudiantes de psicología.  Aunque la temática es ampliamente conocida en el nivel universitario, no es lo mismo conocerla que contemplarla para orientar su aplicación.  En el trabajo de tesis realizado se utilizó un enfoque mixto, un diseño fenomenológico, una muestra no probabilística, se tuvo a la vista la documentación de mérito, como lo es, el Diseño Curricular, de la Licenciatura de Psicología y se trabajó una tabla de cotejo.  Posteriormente se realizó el análisis y discusión de resultados.  Los resultados evidencian que en el Diseño Curricular objeto de estudio, se contempla de manera muy vaga la Política Ambiental de la USAC, toda vez que, no aparece en su Misión.  Se concluye que se debe incluir la Política Ambiental mencionada, con el objetivo de alcanzar la formación integral de los educandos y un perfil de egreso en el cual los estudiantes hayan adquirido las competencias necesarias sobre el medio ambiente para beneficio de su comunidad.
La aplicación de estrategias virtuales en la evaluación de competencias
Authors: García Reyes Zoel Isauro
Published: August 2021

La modalidad virtual en el proceso de enseñanza aprendizaje plantea muchas exigencias hacia el docente tales como: implementación de estrategias de enseñanza aprendizaje, la priorización de lo que aprenderán los alumnos, y los mecanismos para lograr ese aprendizaje. De igual manera la evaluación de las competencias es un desafío. Ante esta realidad surge como objetivo de investigación Analizar si las estrategias de evaluación virtual aplicadas por los docentes permiten evaluar las competencias alcanzadas por los estudiantes. La investigación se desarrolló desde un enfoque de investigación Mixta, con un diseño concurrente, ya que permitió conformar o corroborar resultados y efectuar validación cruzada entre datos cuantitativos y cualitativos, tenía un alcance descriptivo en la investigación obteniendo resultados más específicos sobre las estrategias virtuales y evaluación de competencias. La muestra estuvo integrada por 8 docentes y 194 estudiantes con quienes se trabajaron entrevistas, encuestas y un grupo focal.

Entre los resultados obtenidos en la investigación se considera que, si es efectiva la evaluación por competencias siempre y cuando se implementen nuevas metodologías y estrategias virtuales adaptables al contexto del estudiante. Desde otro punto se determina que se encuentran distintas dificultades en la aplicación de herramientas digitales, estrategias de aprendizaje virtuales para la evaluación de competencias en una educación de modalidad virtual. En el estudio se concluye afirmando y señalando la relevancia de contar con experiencias significativas que ayudaron a estudiar, comprender y desarrollar nuevas iniciativas, la necesidad de innovar los procesos de evaluación de competencias.