bluuebunny/crossref_metadata_2025 huggingface dataset:
Understanding Carcinogenesis for Fighting Oral Cancer
Authors: Tanaka Takuji , Ishigamori Rikako
Published: May 2011

Oral cancer is one of the major global threats to public health. Oral cancer development is a tobacco-related multistep and multifocal process involving field cancerization and carcinogenesis. The rationale for molecular-targeted prevention of oral cancer is promising. Biomarkers of genomic instability, including aneuploidy and allelic imbalance, are able to measure the cancer risk of oral premalignancies. Understanding of the biology of oral carcinogenesis will give us important advances for detecting high-risk patients, monitoring preventive interventions, assessing cancer risk, and pharmacogenomics. In addition, novel chemopreventive agents based on molecular mechanisms and targets against oral cancers will be derived from research using appropriate animal carcinogenesis models. New approaches, such as interventions with molecular-targeted agents and agent combinations in high-risk oral individuals, are undoubtedly needed to reduce the devastating worldwide consequences of oral malignancy.
Existence Results for Singular Boundary Value Problem of Nonlinear Fractional Differential Equation
Authors: Cui Yujun
Published: May 2011

By applying a fixed point theorem for mappings that are decreasing with respect to a cone, this paper investigates the existence of positive solutions for the nonlinear fractional boundary value problem: , 0 < t < 1, u(0) = u′(0) = u′(1) = 0, where 2 < α < 3, is the Riemann‐Liouville fractional derivative.
Metabolic Changes after Urinary Diversion
Authors: Van der Aa Frank , Joniau Steven , Van Den Branden Marcel , Van Poppel Hein
Published: May 2011

Urinary diversion is performed on a regular basis in urological practice. Surgeons tend to underestimate the metabolic effects of any type of diversion. From the patient's perspective, diarrhea is the most bothersome complaint after urinary diversion. This might be accompanied by malabsorption syndromes, such as vitamin B12 deficiency. Electrolyte abnormalities can occur frequently such as hyperchloremic metabolic acidosis, or less frequently such as hypokalemia, hypocalcaemia, and hypomagnesaemia. Bone health is at risk in patients with urinary diversion. Some patients might benefit from vitamin D and calcium supplementation. Many patients are also subject to urinary calculus formation, both at the level of the upper urinary tract as in intestinal reservoirs. Urinary diversion can affect hepatic metabolism, certainly in the presence of urea-splitting bacteria. The kidney function has to be monitored prior to and lifelong after urinary diversion. Screening for reversible causes of renal deterioration is an integral part of the followup.
WEE1 Kinase Targeting Combined with DNA-Damaging Cancer Therapy Catalyzes Mitotic Catastrophe
Authors: De Witt Hamer Philip C. , Mir Shahryar E. , Noske David , Van Noorden Cornelis J.F. , Würdinger Tom
Published: May 2011

WEE1 kinase is a key molecule in maintaining G2–cell-cycle checkpoint arrest for premitotic DNA repair. Whereas normal cells repair damaged DNA during G1-arrest, cancer cells often have a deficient G1-arrest and largely depend on G2-arrest. The molecular switch for the G2–M transition is held by WEE1 and is pushed forward by CDC25. WEE1 is overexpressed in various cancer types, including glioblastoma and breast cancer. Preclinical studies with cancer cell lines and animal models showed decreased cancer cell viability, reduced tumor burden, and improved survival after WEE1 inhibition by siRNA or small molecule inhibitors, which is enhanced by combination with conventional DNA-damaging therapy, such as radiotherapy and/or cytostatics. Mitotic catastrophe results from premature entry into mitosis with unrepaired lethal DNA damage. As such, cancer cells become sensitized to conventional therapy by WEE1 inhibition, in particular those with insufficient G1-arrest due to deficient p53 signaling, like glioblastoma cells. One WEE1 inhibitor has now reached clinical phase I studies. Dose-limiting toxicity consisted of hematologic events, nausea and/or vomiting, and fatigue. The combination of DNA-damaging cancer therapy with WEE1 inhibition seems to be a rational approach to push cancer cells in mitotic catastrophe. Its safety and efficacy are being evaluated in clinical studies. Clin Cancer Res; 17(13); 4200–7. ©2011 AACR.
Association between Posttraumatic Stress Disorder and Preflood Behavioral Characteristics among Children Aged 7–15 Years in Hunan, China
Authors: Peng Minning , Liu Aizhong , Zhou Jia , Wen Shiwu , Li Shuoqi , Yang Tubao , Li Xingli , Huang Xin , Abuaku Benjamin , Tan Hongzhuan
Published: May 2011

Objective: To explore the relationship between posttraumatic stress disorder (PTSD) and preflood behavioral characteristics among children aged 7–15 years in Hunan, China. Subjects and Methods: In 2000, a retrospective study was carried out among children who had been exposed to the 1998 floods in Hunan. A multistage sampling method was used to select subjects from the flood-affected areas. A structured questionnaire administered to the children selected was used to diagnose PTSD based on the DSM-IV criteria. A parent questionnaire was used to measure preflood behavioral characteristics related to health, behavioral, and habit problems. The association between PTSD and preflood behavioral characteristics was assessed using χ2-tests and multivariate logistic regression. Results: A total of 7,038 children from 13,450 households, aged 7–15 years, were investigated. The overall prevalence of PTSD was 2.05%. Generally, the PTSD-positive rate increased with increasing scores for behavioral characteristics. Conclusion: Preflood behavioral characteristics are an important factor influencing the prevalence of PTSD among children exposed to floods. It is therefore necessary to give special attention to children with behavioral problems in order to reduce the psychological impact of floods.
Prevalence and Profile of Back Pain in Nigerian Adolescents
Authors: Ayanniyi Olusola , Mbada Chidozie Emmanuel , Muolokwu Chinyere Agatha
Published: May 2011

Objective: This study aimed to investigate prevalence, characteristics, perceived predisposing factors and mode of treatment sought for back pain among school-aged adolescents in Nigeria. Subjects and Methods: A self-administered questionnaire employed in this cross-sectional study was distributed to 4,400 students [mean age 15.0 ± 1.7 years (range 10–19)] from 44 randomly selected schools. Results: Of the 4,400 questionnaires, 3,185 were completed (1,455 boys and 1,730 girls), thereby yielding a response rate of 72.4%. The lifetime and point prevalence of back pain were 59 and 17%, respectively. Low back pain was the most prevalent type, reported by 25%. The prevalence of back pain was 59.7% among boys and 57.5% among girls. Back pain was significantly associated with age, religion and involvement in commercial activity (p < 0.05). Among those with back pain, most cases were mild (56%), but chronic in 21%, and 27% used self-medication. Prolonged sitting posture (17%) was the most implicated predisposing factor to back pain. Conclusion: Back pain is common among Nigerian adolescent students, but it is mostly mild. The prevalence of back pain increased with advancing age in both genders. More research is needed to find necessary risk factors and interventions including appropriate back education to reduce back pain.
T Helper Type 1/T Helper Type 17-Related Cytokines in Chronic Hepatitis C Patients before and after Interferon and Ribavirin Therapy
Authors: Fathy Amal , Ahmed Amal S. , Metwally Lobna , Hassan Adel
Published: May 2011

Objective: This study examined the T helper (Th) 1/Th17-related cytokines, interferon (IFN)-γ and interleukin (IL)-17 in the serum of biopsy-proven chronic hepatitis C patients before and after IFN and ribavirin therapy to address whether or not viral clearance is related to Th1/Th17 cytokines. Subjects and Methods: The serum levels of IFN-γ and IL-17 were assayed by ELISA on 26 patients with chronic hepatitic C virus (HCV) infection before the start and 3 months after treatment with pegylated IFN-α plus ribavarin and compared with sera from 15 normal control subjects. Results: IFN-γ and IL-17 levels are higher in the serum of patients with chronic hepatitis than in normal controls and these elevated levels were not directly correlated (r = –0.01, p = 0.96 for IFN-γ and r = –0.08, p = 0.66 for IL-17) to the viremic state of the HCV infection. In contrast to IL-17, IFN-γ showed significant reduction after 12 weeks of treatment with pegylated IFN plus ribavirin. However, IFN-γ and IL-17 serum levels were not significantly (p = 0.19 and = 0.70, respectively) different among responders and nonresponders for pegylated IFN plus ribavirin therapy. Conclusion: Our findings suggest that the combined treatment with pegylated IFN-α and ribavirin downmodulates the secretion of key cytokine IFN-γ as early as 12 weeks after treatment in infected patients. These findings could encourage new exciting possibilities for immune-based interventions with the aim of restoring functional antiviral T cell responses combined with improved viral clearance.
Sugar Alcohol Sweeteners as Alternatives to Sugar with Special Consideration of Xylitol
Authors: Mäkinen Kauko K.
Published: May 2011

Introduction: Dental caries is a diet-associated disease which continues to be a serious health problem in most industrialized and developing countries. Strategies to maximize caries prevention should automatically consider the use of sugar substitutes. It is important that public health authorities are made cognizant of the availability of new polyol-type sugar substitutes. Review Summary: Clinical studies have shown that xylitol, a natural, physiologic sugar alcohol of the pentitol type, can be used as a safe and effective caries-limiting sweetener. Habitual use of xylitol-containing food and oral hygiene adjuvants has been shown to reduce the growth of dental plaque, to interfere with the growth of caries-associated bacteria, to decrease the incidence of dental caries, and to be associated with remineralization of caries lesions. Numerous public regulatory bodies have endorsed the use of xylitol as a caries-limiting agent. Other sugar alcohols that have been successfully used as sugar substitutes include D-glucitol (sorbitol), which, however, owing to its hexitol nature, normally has no strong effect on the mass and adhesiveness of bacterial plaque and on the growth of mutans streptococci. A tetritol-type alditol, erythritol, has shown potential as a non-cariogenic sugar substitute. Combinations of xylitol and erythritol may reduce the incidence of caries more effectively than either alditol alone. Conclusions: Partial sugar substitution with polyols is an important dietary tool in the prevention of dental caries that should be used to enhance existing fluoride-based caries prevention programmes. The most effective method of conveying this information to the public is through a proper health claim for these alditols in food labelling. The present review summarizes clinical and biochemical aspects of the above three dietary polyols and emphasizes the role of sugar substitution as a potential health-promoting strategy.
Hand Hygiene Practices among Nursing Staff in Public Secondary Care Hospitals in Kuwait: Self-Report and Direct Observation
Authors: Al-Wazzan Batool , Salmeen Yasmeen , Al-Amiri Eisa , Abul Ala’a , Bouhaimed Manal , Al-Taiar Abdullah
Published: May 2011

Objective: To assess the compliance with hand hygiene guidelines among nursing staff in secondary care hospitals in Kuwait. Subjects and Methods: A cross-sectional study was conducted through direct observation using the Lewisham observation tool and self-administered questionnaire in six major public secondary care hospitals in Kuwait. Only patient care activities that are described as ‘dirty contacts’ by the Fulkerson scale were considered as indications for hand hygiene while any attempt for hand hygiene was considered as compliance. A self-administered questionnaire was prepared and pilot tested and then distributed to nursing staff at each ward immediately after conducting the inspection; 550 were distributed and 454 were completed and returned. Among 204 observation sessions, a total of 935 opportunities and 312 hand hygiene practices were recorded. Results: The overall compliance was 33.4%. The observed compliance significantly varied between different ward categories from 14.7% in emergency to 55% in medical wards. Of the 454 nursing staff who participated in self-reported compliance, 409 (90%) indicated that they always washed their hands upon practicing patient care activities. Nurses consistently reported higher compliance after conducting patient care activities rather than before. Being busy with work (42.2%), having sore/dry hands (30.4%) and wearing gloves (20.3%) were the most frequently reported hindrances to improving hand hygiene. Conclusion: Observed hand hygiene compliance among nursing staff in secondary care hospitals in Kuwait was poor. High self-reported compliance may reflect a high level of awareness of hand hygiene but may also suggest that improving compliance through increasing awareness has probably reached saturation.
Can Capsule Endoscopy Be Used as a Diagnostic Tool in the Evaluation of Nonbleeding Indications in Daily Clinical Practice? A Prospective Study
Authors: Katsinelos P. , Tziomalos K. , Fasoulas K. , Paroutoglou G. , Koufokotsios A. , Mimidis K. , Terzoudis S. , Maris T. , Beltsis A. , Geros C. , Chatzimavroudis G.
Published: May 2011

Objective: To evaluate the diagnostic yield of capsule endoscopy (CE) and its impact on treatment and outcome in patients without bleeding indications. Subjects and Methods: One hundred and sixty-five nonbleeding patients were enrolled in the study. The most common indications for CE were chronic abdominal pain alone (33 patients) or combined with chronic diarrhea (31 patients) and chronic diarrhea alone (30 patients). Among the 165 patients, 129 underwent CE for evaluation of gastrointestinal symptoms and 36 for surveillance or disease staging. Results: CE findings were positive, suspicious and negative in 73 (44.2%), 13 (7.9%) and 79 (47.9%) of cases, respectively. The diagnostic yield was highest in patients with refractory celiac disease (10/10, 100%) and suspected Crohn’s disease (5/6, 83.3%), followed by patients with chronic abdominal pain and chronic diarrhea (13/31, 41.9%), established Crohn’s disease (2/6, 33.3%), chronic diarrhea alone (8/30, 26.7%), chronic abdominal pain alone (8/33, 24.2%) and other indications (3/13, 23.1%) (p < 0.005). The CE findings led to a change of medication in 74 (47.7%) patients, surgery in 15 (9.7%), administration of a strict gluten-free or other special diet in 13 (8.4%) and had other consequences in 11 (6.7%). Management was not modified in 42 (27.1%) patients. Among symptomatic patients (n = 129), 29 (22.5%) were lost to follow-up. The remaining 100 patients were followed up for 8.7 ± 4.0 months (range 2–19). Among the latter, resolution or improvement of symptoms was observed in 86 (86%) patients, no change in 11 (11%) and 3 (3%) died. All 86 patients who experienced resolution or improvement of their symptoms had a modification of their management after CE; only 7/11 patients whose symptoms did not change (63.6%) and 2/3 patients who died (66.7%) had a modification of management (p < 0.001). Conclusions: CE appears to be a useful tool in the evaluation of patients with nonbleeding indications. The outcome of most patients with negative findings was excellent.
Coexistence of Fatal Disseminated Invasive Aspergillosis and Pyoderma Gangrenosum: A Case Report
Authors: Yang Chien-Chang , Hsu Po-Chang , Cheng Chun-Wen , Lee Ming-Hsun
Published: May 2011

Objective: To report an unusual case of disseminated aspergillosis involving the lymph nodes, lungs, and skin in a patient with pyoderma gangrenosum (PG) and myelodysplastic syndrome (MDS). Case Presentation and Intervention: A 46-year-old man presented with productive cough of 2 weeks’ duration. Besides, several painless, fixed lymph nodes were palpated at his left neck. He had PG and MDS diagnosed in June 2004 with regular use of oral dapsone and prednisolone. His skin lesions healed with scar formation and no purulent discharge. A computed tomography scan of the head, neck and chest showed bilateral lung consolidation and abscesses at the left neck, right upper lung and right pleura. The neck abscess culture grew Aspergillus species. Dark reddish macules developed over the right arm, chest and abdominal wall, and the left lower limb 2 weeks after initiation of amphotericin B. The histology of the right arm skin biopsy showed invasive aspergillosis. Caspofungin was started then for suspicion of poor response to amphotericin B. He expired despite 35 days of antifungal therapy. Conclusion: This report highlights the rarity of coexistence of disseminated aspergillosis and PG, and should alert physicians to the possibility of invasive fungal infection superimposed on a chronic skin lesion.
Non-Participation in a Randomized Controlled Trial: The Effect on Clinical and Non-Clinical Variables
Authors: Vermaire J.H. , van Loveren C. , Poorterman J.H.G. , Hoogstraten J.
Published: May 2011

Studies reporting clinical and non-clinical parameters of participants and non-participants of clinical trials are scarce. In the available studies non-participants were likely to show less favourable outcomes than participants on both socioeconomic parameters as well as on caries experience. However, the impact of non-participation on the total sample of the research population is not established. In the present study, as part of baseline data collection for a randomized controlled trial on caries-preventive strategies, 346 parents of children 6.0 years (± 3 months) of age were approached to let their child participate. Sixty parents refused, but 56 of them were willing to fill out the same set of questionnaires and to allow their child to be clinically examined once. Parents from participating children had higher socioeconomic status, were more often of autochthonous origin and scored better on knowledge questions than parents of non-participating children. Furthermore, parents of participating children reported a higher willingness to invest, were more likely to hold on to regular meals and their child had lower levels of plaque compared to non-participating children. Surprisingly, the participating children had higher dmfs scores than the non-participating children. Their care index (fs/ds + fs) was higher than that of non-participating children. Based on the findings of this study, the presumption that non-participating children will show less favourable clinical outcomes cannot be supported. Although participants differed from non-participants, they did not differ from the total population. It is suggested that the external validity of a randomized controlled trial on caries-preventive strategies is not necessarily affected by non-participation bias.
Health-Related Quality of Life in Multiple System Atrophy and Progressive Supranuclear Palsy
Authors: Winter Yaroslav , Spottke Annika E. , Stamelou Maria , Cabanel Nicole , Eggert Karla , Höglinger Günter U. , Sixel-Doering Friederike , Herting Birgit , Klockgether Thomas , Reichmann Heinz , Oertel Wolfgang H. , Dodel Richard
Published: May 2011

Objective: Multiple system atrophy (MSA) and progressive supranuclear palsy (PSP), known as atypical parkinsonian syndromes (APS), are neurodegenerative disorders with severe disability and decreased life expectancy. Little is known about the health-related quality of life (HrQoL) and its determinants in patients with those disorders. The objective of our cross-sectional study was to evaluate the HrQoL in patients with APS and to identify the determinants of HrQoL. Methods: A total of 101 consecutive patients with MSA (n = 54) and PSP (n = 47) were recruited in four German neurological centers. Disease severity was assessed using the Hoehn and Yahr stages and the Unified MSA Rating Scale. The HrQoL was evaluated using the EuroQol instrument (EQ-5D and EQ-VAS). Independent determinants of HrQoL were identified in multiple regression analyses. Results: The mean EQ-VAS score was 52% lower than that reported for the general population (36.9 ± 18.3 vs. 77.4 ± 19.0). Of the study participants, 63% reported severe problems in at least one dimension of the EQ-5D. Cerebellar dysfunction was associated with a more considerable reduction of HrQoL. Independent determinants of reduced HrQoL were female gender, <12 years of education, disease severity, a decreased number of persons in the household and depression. Conclusions: The HrQoL in MSA and PSP is considerably reduced. While therapeutic options in the treatment of motor symptoms remain restricted, greater attention should be paid to the treatment of depression, which was identified among independent determinants of HrQoL. Independent determinants of HrQoL should be considered when developing healthcare programs aimed at improving the HrQoL in APS.
Natural Products in Caries Research: Current (Limited) Knowledge, Challenges and Future Perspective
Authors: Jeon J.-G. , Rosalen P.L. , Falsetta M.L. , Koo H.
Published: May 2011

Dental caries is the most prevalent and costly oral infectious disease worldwide. Virulent biofilms firmly attached to tooth surfaces are prime biological factors associated with this disease. The formation of an exopolysaccharide-rich biofilm matrix, acidification of the milieu and persistent low pH at the tooth-biofilm interface are major controlling virulence factors that modulate dental caries pathogenesis. Each one offers a selective therapeutic target for prevention. Although fluoride, delivered in various modalities, remains the mainstay for the prevention of caries, additional approaches are required to enhance its effectiveness. Available antiplaque approaches are based on the use of broad-spectrum microbicidal agents, e.g. chlorhexidine. Natural products offer a rich source of structurally diverse substances with a wide range of biological activities, which could be useful for the development of alternative or adjunctive anticaries therapies. However, it is a challenging approach owing to complex chemistry and isolation procedures to derive active compounds from natural products. Furthermore, most of the studies have been focused on the general inhibitory effects on glucan synthesis as well as on bacterial metabolism and growth, often employing methods that do not address the pathophysiological aspects of the disease (e.g. bacteria in biofilms) and the length of exposure/retention in the mouth. Thus, the true value of natural products in caries prevention and/or their exact mechanisms of action remain largely unknown. Nevertheless, natural substances potentially active against virulent properties of cariogenic organisms have been identified. This review focuses on gaps in the current knowledge and presents a model for investigating the use of natural products in anticaries chemotherapy.
Microparticles in Hemostasis and Thrombosis
Authors: Owens A. Phillip , Mackman Nigel
Published: May 2011

Blood contains microparticles (MPs) derived from a variety of cell types, including platelets, monocytes, and endothelial cells. In addition, tumors release MPs into the circulation. MPs are formed from membrane blebs that are released from the cell surface by proteolytic cleavage of the cytoskeleton. All MPs are procoagulant because they provide a membrane surface for the assembly of components of the coagulation protease cascade. Importantly, procoagulant activity is increased by the presence of anionic phospholipids, particularly phosphatidylserine (PS), and the procoagulant protein tissue factor (TF), which is the major cellular activator of the clotting cascade. High levels of platelet-derived PS
+
MPs are present in healthy individuals, whereas the number of TF
+
, PS
+
MPs is undetectable or very low. However, levels of PS
+
, TF
+
MPs are readily detected in a variety of diseases, and monocytes appear to be the primary cellular source. In cancer, PS
+
, TF
+
MPs are derived from tumors and may serve as a useful biomarker to identify patients at risk for venous thrombosis. This review will summarize our current knowledge of the role of procoagulant MPs in hemostasis and thrombosis.
The Temporal Dynamics of Object Processing in Visual Cortex during the Transition from Distributed to Focused Spatial Attention
Authors: Wu Chien-Te , Libertus Melissa E. , Meyerhoff Karen L. , Woldorff Marty G.
Published: May 2011

Several major cognitive neuroscience models have posited that focal spatial attention is required to integrate different features of an object to form a coherent perception of it within a complex visual scene. Although many behavioral studies have supported this view, some have suggested that complex perceptual discrimination can be performed even with substantially reduced focal spatial attention, calling into question the complexity of object representation that can be achieved without focused spatial attention. In the present study, we took a cognitive neuroscience approach to this problem by recording cognition-related brain activity both to help resolve the questions about the role of focal spatial attention in object categorization processes and to investigate the underlying neural mechanisms, focusing particularly on the temporal cascade of these attentional and perceptual processes in visual cortex. More specifically, we recorded electrical brain activity in humans engaged in a specially designed cued visual search paradigm to probe the object-related visual processing before and during the transition from distributed to focal spatial attention. The onset times of the color popout cueing information, indicating where within an object array the subject was to shift attention, was parametrically varied relative to the presentation of the array (i.e., either occurring simultaneously or being delayed by 50 or 100 msec). The electrophysiological results demonstrate that some levels of object-specific representation can be formed in parallel for multiple items across the visual field under spatially distributed attention, before focal spatial attention is allocated to any of them. The object discrimination process appears to be subsequently amplified as soon as focal spatial attention is directed to a specific location and object. This set of novel neurophysiological findings thus provides important new insights on fundamental issues that have been long-debated in cognitive neuroscience concerning both object-related processing and the role of attention.
The Interaction of Lexical Semantics and Cohort Competition in Spoken Word Recognition: An fMRI Study
Authors: Zhuang Jie , Randall Billi , Stamatakis Emmanuel A. , Marslen-Wilson William D. , Tyler Lorraine K.
Published: May 2011

Spoken word recognition involves the activation of multiple word candidates on the basis of the initial speech input—the “cohort”—and selection among these competitors. Selection may be driven primarily by bottom–up acoustic–phonetic inputs or it may be modulated by other aspects of lexical representation, such as a word's meaning [Marslen-Wilson, W. D. Functional parallelism in spoken word-recognition. Cognition, 25, 71–102, 1987]. We examined these potential interactions in an fMRI study by presenting participants with words and pseudowords for lexical decision. In a factorial design, we manipulated (a) cohort competition (high/low competitive cohorts which vary the number of competing word candidates) and (b) the word's semantic properties (high/low imageability). A previous behavioral study [Tyler, L. K., Voice, J. K., & Moss, H. E. The interaction of meaning and sound in spoken word recognition. Psychonomic Bulletin & Review, 7, 320–326, 2000] showed that imageability facilitated word recognition but only for words in high competition cohorts. Here we found greater activity in the left inferior frontal gyrus (BA 45, 47) and the right inferior frontal gyrus (BA 47) with increased cohort competition, an imageability effect in the left posterior middle temporal gyrus/angular gyrus (BA 39), and a significant interaction between imageability and cohort competition in the left posterior superior temporal gyrus/middle temporal gyrus (BA 21, 22). In words with high competition cohorts, high imageability words generated stronger activity than low imageability words, indicating a facilitatory role of imageability in a highly competitive cohort context. For words in low competition cohorts, there was no effect of imageability. These results support the behavioral data in showing that selection processes do not rely solely on bottom–up acoustic–phonetic cues but rather that the semantic properties of candidate words facilitate discrimination between competitors.
The Neural Basis of Parallel Saccade Programming: An fMRI Study
Authors: Hu Yanbo , Walker Robin
Published: May 2011

The neural basis of parallel saccade programming was examined in an event-related fMRI study using a variation of the double-step saccade paradigm. Two double-step conditions were used: one enabled the second saccade to be partially programmed in parallel with the first saccade while in a second condition both saccades had to be prepared serially. The intersaccadic interval, observed in the parallel programming (PP) condition, was significantly reduced compared with latency in the serial programming (SP) condition and also to the latency of single saccades in control conditions. The fMRI analysis revealed greater activity (BOLD response) in the frontal and parietal eye fields for the PP condition compared with the SP double-step condition and when compared with the single-saccade control conditions. By contrast, activity in the supplementary eye fields was greater for the double-step condition than the single-step condition but did not distinguish between the PP and SP requirements. The role of the frontal eye fields in PP may be related to the advanced temporal preparation and increased salience of the second saccade goal that may mediate activity in other downstream structures, such as the superior colliculus. The parietal lobes may be involved in the preparation for spatial remapping, which is required in double-step conditions. The supplementary eye fields appear to have a more general role in planning saccade sequences that may be related to error monitoring and the control over the execution of the correct sequence of responses.
Right Frontal Lobe Mediation of Recollection- and Familiarity-based Verbal Recognition Memory: Evidence from Patients with Tumor Resections
Authors: Anderson Nicole D. , Davidson Patrick S. R. , Mason Warren P. , Gao Fuqiang , Binns Malcolm A. , Winocur Gordon
Published: May 2011

Medial-temporal, parietal, and pFC regions have been implicated in recollection and familiarity, but existing evidence from neuroimaging and patient studies is limited and conflicting regarding the role of specific regions within pFC in these memory processes. We report a study of 20 patients who had undergone resection of right frontal lobe tumors and 20 matched healthy control participants. The location and extent of lesions were traced on the patients' scans. A process dissociation procedure was employed to yield estimates of the contributions of recollection and familiarity in verbal recognition performance. Group comparisons revealed deficits in recollection but not familiarity in the patient group relative to their healthy counterparts. We found a positive relationship between estimates of familiarity and lesion sizes in the right inferior pFC (BA 11, 47) which was significant upon bootstrap resampling. These results are discussed in terms of prior work linking this area to an overextended sense of familiarity.
Measuring Environmental Favorability for Tropical Cyclogenesis by Statistical Analysis of Threshold Parameters
Authors: McGauley Michael G. , Nolan David S.
Published: May 2011

As the climate changes, the ability to predict changes in the frequency of tropical cyclogenesis is becoming of increasing interest. A unique approach is proposed that utilizes threshold values in potential intensity, wind shear, vorticity, and normalized saturation deficit. Prior statistical methods generally involve creating an index or equation based on averages of important meteorological parameters for a given region. The new method assumes that threshold values exist for each important parameter for which cyclogenesis is unlikely to develop. This technique is distinct from previous approaches that seek to determine how each of these parameters interdependently favors cyclogenesis.

To determine three of the individual threshold values (shear, potential intensity, and vorticity), an idealized climate is first established that represents the most advantageous but realistic (MABR) environment. An initial numerical simulation of tropical cyclone genesis in the MABR environment confirms that it is highly favorable for cyclogenesis. Subsequent numerical simulations vary each parameter individually until no tropical cyclone develops, thereby determining the three threshold values. The new method of point downscaling, whereby background meteorological features are represented by a single vertical profile, is used in the simulations to greatly simplify the approach. The remaining threshold parameter (normalized saturation deficit) is determined by analyzing the climatological record and choosing a value that is statistically observed to prevent cyclogenesis. Once each threshold value is determined, the fraction of time each is exceeded in the location of interest is computed from the reanalysis dataset. The product of each fraction for each of the relevant parameters then gives a statistical probability as to the likelihood of cyclogenesis. For predicting regional and monthly variations in frequency of genesis, this approach is shown to generally meet or exceed the predictive skills of earlier statistical attempts with some failure only during several off-season months. This method also provides a more intuitive rationale of the results.
Projections of Future Drought in the Continental United States and Mexico
Authors: Wehner Michael , Easterling David R. , Lawrimore Jay H. , Heim Richard R. , Vose Russell S. , Santer Benjamin D.
Published: May 2011

Using the Palmer drought severity index, the ability of 19 state-of-the-art climate models to reproduce observed statistics of drought over North America is examined. It is found that correction of substantial biases in the models’ surface air temperature and precipitation fields is necessary. However, even after a bias correction, there are significant differences in the models’ ability to reproduce observations. Using metrics based on the ability to reproduce observed temporal and spatial patterns of drought, the relationship between model performance in simulating present-day drought characteristics and their differences in projections of future drought changes is investigated. It is found that all models project increases in future drought frequency and severity. However, using the metrics presented here to increase confidence in the multimodel projection is complicated by a correlation between models’ drought metric skill and climate sensitivity. The effect of this sampling error can be removed by changing how the projection is presented, from a projection based on a specific time interval to a projection based on a specified temperature change. This modified class of projections has reduced intermodel uncertainty and could be suitable for a wide range of climate change impacts projections.
Four-Dimensional Assimilation of Multitime Wind Profiles over a Single Station and Numerical Simulation of a Mesoscale Convective System Observed during IHOP_2002
Authors: Zhang Lei , Pu Zhaoxia
Published: May 2011

This study examines the impact of assimilating multitime wind profiles over a single station on the numerical simulation of a warm season mesoscale convective system over the region from the Kansas and Oklahoma border to the Texas Panhandle, observed 12–13 June 2002 during the International H2O Project (IHOP_2002). Wind profile observations, obtained from Goddard Lidar Observatory for Winds (GLOW) are assimilated into an advanced research version of the Weather Research and Forecasting (WRF) model using its four-dimensional variational data assimilation (4DVAR) system. Results indicate that the assimilation of high temporal and vertical resolution GLOW wind profiles has a significant influence on the numerical simulation of the convective initiation and evolution. Besides the wind fields, the structure of the moisture fields associated with the convective system is also improved. Data assimilation has also resulted in a more accurate prediction of the locations and timing of the convection initiations; as a consequence, the skill of quantitative precipitation forecasting is enhanced greatly.

The positive impact of 4DVAR assimilation of multitime wind profiles over a single station on the mesoscale prediction in this study presents a successful procession of the traditional technique in time to space conversion. However, when the data from conventional networks are assimilated into the model with GLOW wind profiles, the data impact is not compatible with that from the assimilation of GLOW wind profiles only, implying the need for a high temporal and spatial resolution wind profile network in order to achieve reasonable mesoscale analysis and forecasting.
Differential Characteristics of Inflammatory Responses to Stent Implantation Between De Novo and Intrastent Restenosis Lesion in Patients With Stable Angina
Authors: Hikita Hiroyuki , Kuroda Shunsuke , Kawaguchi Naohiko , Nakashima Emiko , Fujinami Tatsuya , Sugiyama Tomoyo , Kamiishi Tetsuo , Takahashi Yoshihide , Nozato Toshihiro , Kuwahara Taishi , Satoh Akira , Takahashi Atsushi , Isobe Mitsuaki
Published: May 2011

Mechanical plaque rupture of coronary atherosclerotic plaque during stent implantation can increase serum levels of high-sensitivity C-reactive protein (hsCRP). Patients with stable angina pectoris were divided into 2 groups: one group included 186 patients with de novo lesion who underwent stent implantation (de novo group); the other group included 40 patients with intrastent restenosis (ISR) undergoing stent implantation (ISR group). The de novo group had a significant increase in hsCRP levels post stenting, while the ISR group showed no increase in hsCRP post stenting. Intravascular ultrasound with radiofrequency data analysis showed that the de novo group had larger percentage of both necrotic core area and fibrofatty area at the target lesion than the ISR group, while the ISR group had a larger percentage of fibrous area. Differential inflammatory response to stent implantation between the de novo plaque and in ISR lesion is related to lesion morphology.
Prevalence, Predictors, and Outcomes of Conservative Medical Management in Non-ST-Segment Elevation Acute Coronary Syndromes in Gulf RACE-2
Authors: AlHabib Khalid F. , Hersi Ahmad , Alsheikh-Ali Alawi A. , Sulaiman Kadhim , Alfaleh Hussam , Alsaif Shukri , Almahmeed Wael , Asaad Nidal , Amin Haitham , Al-Motarreb Ahmed , Al-Lawati Jawad , Suwaidi Jassim Al
Published: May 2011

We assessed the prevalence, predictors, and in-hospital and long-term outcomes of conservative medical management for patients with non-ST-segment elevation acute coronary syndrome (NSTEACS) compared with percutaneous coronary intervention (PCI) and coronary artery bypass graft surgery (CABG). This prospective study conducted from October 2008 to June 2009 in 65 hospitals from 6 Arabian Gulf countries included 30-day and 1-year mortality follow-up for 3661 patients. Compared with conservative management group (2859 patients; 78.1%), the PCI group (638; 17.4%) had significantly better unadjusted and adjusted in-hospital (odds ratio [OR]: 0.40, 95% confidence interval [CI]: 0.17-0.97), 30-day (OR: 0.44, 95% CI: 0.24-0.76) and 1-year (OR: 0.58, 95% CI: 0.40-0.87) mortality rates. Comparison with the CABG group (164; 4.5%) yielded similar results with inclusion of patients scheduled for CABG after hospital discharge. Independent predictors of conservative medical management were mainly country of residence and history of prior CABG.
Effects of an Environmental Education Course on Consensus Estimates for Proenvironmental Intentions
Authors: Hovardas Tasos , Korfiatis Konstantinos
Published: May 2011

An environmental education intervention in a university conservation-related course was designed to decrease students’ errors in consensus estimates for proenvironmental intentions, that is, their errors in guessing their classmates’ proenvironmental intentions. Before and after the course, the authors measured two intentions regarding willingness to contribute money and volunteer work for environmental causes. The false consensus effect, whereby contributors provide significantly higher consensus estimates compared with noncontributors, was displayed both before and after the course. Specifically, students intending to contribute believed most (51%-54%) of their classmates would contribute, and students not intending to contribute believed fewer (28%-35%) of their classmates would contribute. Accuracy in estimating consensus increased significantly after the course. Errors in consensus estimates were significant predictors of behavioral intentions. The study showed that the theoretical and methodological background of environmental education interventions can be enriched by incorporating consensus estimates for proenvironmental intentions in assessment procedures.
The Role of Self-Perceptions in the Prediction of Household Recycling Behavior in Australia
Authors: White Katherine M. , Hyde Melissa K.
Published: May 2011

This study examined the role of self-perceptions, within a theory of planned behavior (TPB) framework, in the prediction of householders’ recycling intentions and behavior. To examine additional self-perception constructs, the personality factor of conscientiousness (as well as its lower order facets) and measures of self-identity were assessed in addition to the standard TPB predictors of attitude, subjective norm, and perceived behavioral control (PBC). Participants from the general community ( N = 200) completed TPB, conscientiousness, and self-identity items. Two weeks later, 148 participants reported their recycling behavior for the previous fortnight. Structural equation modeling found some support for the standard TPB with attitude and subjective norm (but not PBC) predicting recycling intentions and intentions (but not PBC) predicting recycling behavior. In addition, self-identity as a recycler but not conscientiousness (or its lower order facets) emerged as a significant predictor of recycling intentions, although not as a significant determinant of actual recycling behavior. The findings of the present study highlight the importance of considering role-related perceptions in the development of prorecycling campaigns.
High School Music Ensemble Students in the United States
Authors: Elpus Kenneth , Abril Carlos R.
Published: May 2011

The purpose of this study is to construct a national demographic profile of high school band, choir, and orchestra students in the United States using evidence from the 2004 follow-up wave of the Education Longitudinal Study of 2002. Results indicate that 21% of seniors in the United States’ class of 2004 participated in school music ensembles. Significant associations were found between music ensemble participation and variables including gender, race/ethnicity, socioeconomic status (SES), native language, parents’ education, standardized test scores, and GPA. Certain groups of students, including those who are male, English language learners, Hispanic, children of parents holding a high school diploma or less, and in the lowest SES quartile, were significantly underrepresented in music programs across the United States. In contrast, white students were significantly overrepresented among music students, as were students from higher SES backgrounds, native English speakers, students in the highest standardized test score quartiles, children of parents holding advanced postsecondary degrees, and students with GPAs ranging from 3.01 to 4.0. Findings indicate that music students are not a representative subset of the population of U.S. high school students.
Primary School Children’s Self-Efficacy for Music Learning
Authors: Ritchie Laura , Williamon Aaron
Published: May 2011

The Self-Efficacy for Musical Learning questionnaire was adapted and tested with 404 primary school children, producing a robust Cronbach alpha (0.87) and confirming a single underlying factor through exploratory factor analysis. Test–retest scores showed the measure’s stability over a 9-month period. Data were collected on children’s prior music experience, extracurricular activities, and typical daily activities. Children also completed the Short Warwick-Edinburgh Mental Well-Being Scale and the Strengths and Difficulties Questionnaire. Those currently engaged in music tuition (learning an instrument or singing) had significantly higher self-efficacy scores than children who were not, and overall, girls’ scores were significantly higher than boys’. Correlations with various additional measures, including wellbeing and reading for pleasure, highlighted multifaceted relationships of self-efficacy to children’s lives. Regression analyses revealed that prior experience with instrumental tuition was the strongest predictor of music self-efficacy for learning; prosocial behaviors predicted boys’ scores, and well-being predicted girls’ scores.
Task-values across subject domains: A gender comparison using a person-centered approach
Authors: Chow Angela , Salmela-Aro Katariina
Published: May 2011

This study examined what kinds of groups can be identified according to students’ task-values across four subject domains (languages, math and science, social sciences, practical subjects) and the related gender differences using a person-centered approach. Latent class analysis was applied to classify 638 students (mean age = 15) into four task-value groups, namely, all-subjects (55%), practical-subjects (5.7%), high-math-and-science (20.2%) and low-math-and-science (19.1%) groups. Significant gender differences were found: boys dominated the high-math-and-science group (boys = 98%), while girls dominated the low-math-and-science group (girls = 82%). Compared to the low-math-and-science group, the high-math-and-science group reported a stronger tendency in furthering their studies immediately after the completion of compulsory education.
Double-Bind Accountability Dilemmas: Impression Management and Accountability Strategies Used by Senior Banking Executives
Authors: Stapleton Karyn , Hargie Owen
Published: May 2011

This article considers issues of impression management and accountability in the context of the U.K. Banking Crisis Inquiry, which took place in February 2009. In this setting, the bankers’ public image was under serious threat and successful impression management depended on their ability to avoid being held responsible for the crisis. However, in attempting to mitigate or deny their own accountability, they generated a further set of a set of conflicting impression management tasks—specifically, a tension between moral or ethical integrity on the one hand and professional credibility on the other. This produced a quandary, which the authors have termed a double-bind accountability dilemma. The authors’ analysis examines instances of this double-bind accountability dilemma as it emerged in the bankers’ evidence and the strategies by which it was negotiated and managed.