bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table S1 from A Genetic Mouse Model of Invasive Endometrial Cancer Driven by Concurrent Loss of Pten and Lkb1 Is Highly Responsive to mTOR Inhibition
Authors: Cheng Hailing , Liu Pixu , Zhang Fan , Xu Erbo , Symonds Lynn , Ohlson Carolynn E. , Bronson Roderick T. , Maira Sauveur-Michel , Di Tomaso Emmanuelle , Li Jane , Myers Andrea P. , Cantley Lewis C. , Mills Gordon B. , Zhao Jean J.
Published: April 2023

Summary of disease phenotypes.
Supplementary Figures 1 - 11 from A Genetic Mouse Model of Invasive Endometrial Cancer Driven by Concurrent Loss of Pten and Lkb1 Is Highly Responsive to mTOR Inhibition
Authors: Cheng Hailing , Liu Pixu , Zhang Fan , Xu Erbo , Symonds Lynn , Ohlson Carolynn E. , Bronson Roderick T. , Maira Sauveur-Michel , Di Tomaso Emmanuelle , Li Jane , Myers Andrea P. , Cantley Lewis C. , Mills Gordon B. , Zhao Jean J.
Published: April 2023

Supplementary Figure 1. Representative images of metastases found in the liver (left panel) and peritoneal wall (right panel) of Pten loxp/loxp Lkb1loxp/loxp female mice bearing Pten Lkb1-deficient endometrial tumors. Supplementary Figure 2. Genotyping of endometrial tumors for the recombined alleles of Pten (A) and Lkb1 (B). Genomic DNAs from Pten Lkb1-deficient endometrial tumors (lanes 1â€“4) or mouse tail (lanes 5) were extracted. PCR analysis was done as previously described (1, 2). Supplementary Figure 3. Representative images of immunohistochemical staining of Pten (A) and Lkb1 (B) proteins in Pten Lkb1-deficient endometrial tumors counterstained with hematoxylin. Bars, 25Î¼M. Normal uterus was shown as a control. Supplementary Figure 4. Representative histopathology images of normal uterus (A) and precursor endometrial lesions (B) from Pten loxp/loxp Lkb1 loxp/loxp female mice with endometrium-specific co-deletion of Pten and Lkb1 (2 weeks post intrauterine injection of Ade-Cre). Scale bars, 25Î¼M. Supplementary Figure 5. Representative images of histopathology of endometrial lesions from Pten loxp/loxp female mice with endometrium-specific deletion of Pten. Mice were sacrificed 10 months post intrauterine injection of Ade-Cre. Scale bars, 50Î¼M. Supplementary Figure 6. Representative histopathology images of endometrial lesions from Lkb1loxp/loxp female mice with endometrium-specific deletion of Lkb1. Mice were sacrificed 10 months post intrauterine injection of Ade-Cre. Scale bars, 100Î¼M. Supplementary Figure 7. Representative images of immunohistochemical staining of CK8 in Pten Lkb1-deficient endometrial tumors. Scale bars, 50Î¼M (left panel); 25Î¼M (right panel). Supplementary Figure 8. Representative histopathology images of metastases found in the lungs of Ptenloxp/loxp Lkb1loxp/loxp female mice bearing Pten Lkb1-deficient endometrial tumors. Bars, 50Î¼M. Supplementary Figure 9. Representative histopathology image of Pten Lkb1-deficient endometrial cancer lesions with desmoplastic stromal response. Scale bar, 25Î¼M. Supplementary Figure 10. Representative images of immunohistochemical staining of proteins as indicated in normal uterus (upper panels, A and B) and Pten Lkb1-deficient endometrial tumors (lower panels, A and B). Scale bars, 25Î¼M.Supplementary Figure 11. Western blot analysis of LKB1 expression in ETN-1 and HEC108 cells with stable expression of vector or flag-tagged LKB1 wild-type. Vinculin was used a loading control.
Supplementary Figure 5 from The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models
Authors: Miyajima Naoto , Tsutsumi Shinji , Sourbier Carole , Beebe Kristin , Mollapour Mehdi , Rivas Candy , Yoshida Soichiro , Trepel Jane B. , Huang Ying , Tatokoro Manabu , Shinohara Nobuo , Nonomura Katsuya , Neckers Len
Published: April 2023

PDF file - 75K, A dose range study of single agent crizotinib and ganetespib in wtMET-driven or mutant MET-driven tumor xenografts.
Supplementary Tables 1 - 4 from LSECtin Expressed on Melanoma Cells Promotes Tumor Progression by Inhibiting Antitumor T-cell Responses
Authors: Xu Feng , Liu Jing , Liu Di , Liu Biao , Wang Min , Hu Zhiyuan , Du Xuemei , Tang Li , He Fuchu
Published: April 2023

PDF file - 71KB, Supplementary Table 1 Characteristics of 7 types of cancer patient in cancer survey array. Supplementary Table 2 Characteristics of patient in melanoma RNA chip. Supplementary Table 3 Characteristics of patient in melanoma IHC chip. Supplementary Table 4. Characteristics of patient in flow cytometry analysis.
Supplementary Materials and Methods from LSECtin Expressed on Melanoma Cells Promotes Tumor Progression by Inhibiting Antitumor T-cell Responses
Authors: Xu Feng , Liu Jing , Liu Di , Liu Biao , Wang Min , Hu Zhiyuan , Du Xuemei , Tang Li , He Fuchu
Published: April 2023

PDF file - 155KB
Supplementary Figure Legends from LSECtin Expressed on Melanoma Cells Promotes Tumor Progression by Inhibiting Antitumor T-cell Responses
Authors: Xu Feng , Liu Jing , Liu Di , Liu Biao , Wang Min , Hu Zhiyuan , Du Xuemei , Tang Li , He Fuchu
Published: April 2023

PDF file - 73KB
Supplementary Figure 6 from LSECtin Expressed on Melanoma Cells Promotes Tumor Progression by Inhibiting Antitumor T-cell Responses
Authors: Xu Feng , Liu Jing , Liu Di , Liu Biao , Wang Min , Hu Zhiyuan , Du Xuemei , Tang Li , He Fuchu
Published: April 2023

PDF file - 90KB, Supplementary Figure 6 Tumor-derived LSECtin stimulates MDSC to express iNOS and promotes MDSC accumulation in spleen, but not in tumor site.
Supplementary Figure 5 from LSECtin Expressed on Melanoma Cells Promotes Tumor Progression by Inhibiting Antitumor T-cell Responses
Authors: Xu Feng , Liu Jing , Liu Di , Liu Biao , Wang Min , Hu Zhiyuan , Du Xuemei , Tang Li , He Fuchu
Published: April 2023

PDF file - 76KB, Supplementary Figure 5 Anti-LSECtin ameliorates B16 melanoma growth.
Supplementary Figure 6 from Higher Frequencies of GARP+CTLA-4+Foxp3+ T Regulatory Cells and Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Are Associated with Impaired T-Cell Functionality
Authors: Kalathil Suresh , Lugade Amit A. , Miller Austin , Iyer Renuka , Thanavala Yasmin
Published: April 2023

PDF file - 139K, Supplementary Figure 6. Intracellular cytokine expression from in vitro stimulated T cells.
Supplementary Figure 5 from Higher Frequencies of GARP+CTLA-4+Foxp3+ T Regulatory Cells and Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Are Associated with Impaired T-Cell Functionality
Authors: Kalathil Suresh , Lugade Amit A. , Miller Austin , Iyer Renuka , Thanavala Yasmin
Published: April 2023

PDF file - 117K, Supplementary Figure 5. Plasmacytoid dendritic cells in HCC patients.
Supplementary Figure 1 from LSECtin Expressed on Melanoma Cells Promotes Tumor Progression by Inhibiting Antitumor T-cell Responses
Authors: Xu Feng , Liu Jing , Liu Di , Liu Biao , Wang Min , Hu Zhiyuan , Du Xuemei , Tang Li , He Fuchu
Published: April 2023

PDF file - 108KB, Supplementary Figure 1 LSECtin is induced to be expressed by murine melanoma tissues.
Supplementary Figure 4 from Higher Frequencies of GARP+CTLA-4+Foxp3+ T Regulatory Cells and Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Are Associated with Impaired T-Cell Functionality
Authors: Kalathil Suresh , Lugade Amit A. , Miller Austin , Iyer Renuka , Thanavala Yasmin
Published: April 2023

PDF file - 117K, Supplementary Figure 4. (A, B) Frequency as well as (C, D) absolute number of MDSC in the peripheral blood of HCC patients was compared after stratification of patients based on exposure to HCV infection or prior treatment.
Supplementary Figure 1 from Distinguishing between Benign and Malignant Melanocytic Nevi by In Vivo Multiphoton Microscopy
Authors: Balu Mihaela , Kelly Kristen M. , Zachary Christopher B. , Harris Ronald M. , Krasieva Tatiana B. , König Karsten , Durkin Anthony J. , Tromberg Bruce J.
Published: April 2023

PDF file - 181KB, Compound nevus. (Upper row) MPM images of normal skin (adjacent to nevus) showing (a) keratinocytes in the stratum spinosum at a depth of 30 microm, (b) basal cells (green) surrounding dermal papilla (blue) - 50 microm deep, (c) collagen fibers in the dermis - 75 microm deep. (Lower row) MPM images of the nevus showing pigmented keratinocytes in the stratum spinosum at a depth of 30 microm (d), basal cells (green) surrounding dermal papilla (blue) at depths of 50 (e) and 75 microm (f). Scale bar is 40 microm. Inset shows the clinical image of the nevus (scale bar is 1 mm).
Supplementary Methods from Distinct Effects of Ligand-Induced PDGFRα and PDGFRβ Signaling in the Human Rhabdomyosarcoma Tumor Cell and Stroma Cell Compartments
Authors: Ehnman Monika , Missiaglia Edoardo , Folestad Erika , Selfe Joanna , Strell Carina , Thway Khin , Brodin Bertha , Pietras Kristian , Shipley Janet , Östman Arne , Eriksson Ulf
Published: April 2023

PDF file - 93K, Includes Gene expression profiles, RNA preparation and qRT-PCR analysis, PDGFRβ stimulation assay, and supplementary references
Supplementary Figure 4 from Distinct Effects of Ligand-Induced PDGFRα and PDGFRβ Signaling in the Human Rhabdomyosarcoma Tumor Cell and Stroma Cell Compartments
Authors: Ehnman Monika , Missiaglia Edoardo , Folestad Erika , Selfe Joanna , Strell Carina , Thway Khin , Brodin Bertha , Pietras Kristian , Shipley Janet , Östman Arne , Eriksson Ulf
Published: April 2023

PDF file - 80K, Myogenic differentiation is impaired in RD cells devoid of PDGF activity. RD cells were cultured for 72 hours under conditions facilitating myogenic differentiation. A, quantification of SA-βgal-positive senescent cells in the presence of CP-673,451 or vehicle. B, cell elongation as a morphological sign of myogenic differentiation in the presence of CP-673,451 or vehicle. C, qRT-PCR analysis for the two myogenic transcripts MYL1 and MYOGENIN and the myogenic repressor HEY-1, a mediator of Notch signaling, in the presence of CP-673,451 or vehicle (0.1% DMSO) (left panel). The right panel shows expression of the same myogenic transcripts in non-differentiated cells and in cells where differentiatiation was induced in the absence of vehicle. All expression values were normalized to the expression in non-differentiated cells (right panel, left bar). Data are presented � SD (*P<0.05, ***P<0.001, Student's t test).
Supplementary Methods and Figure Legend from Interleukin 21–Induced Granzyme B–Expressing B Cells Infiltrate Tumors and Regulate T Cells
Authors: Lindner Stefanie , Dahlke Karen , Sontheimer Kai , Hagn Magdalena , Kaltenmeier Christof , Barth Thomas F.E. , Beyer Thamara , Reister Frank , Fabricius Dorit , Lotfi Ramin , Lunov Oleg , Nienhaus G. Ulrich , Simmet Thomas , Kreienberg Rolf , Möller Peter , Schrezenmeier Hubert , Jahrsdörfer Bernd
Published: April 2023

PDF file - 87K
Supplementary Methods, Figures 1 - 2, Table 1 from Spreaders and Sponges Define Metastasis in Lung Cancer: A Markov Chain Monte Carlo Mathematical Model
Authors: Newton Paul K. , Mason Jeremy , Bethel Kelly , Bazhenova Lyudmila , Nieva Jorge , Norton Larry , Kuhn Peter
Published: April 2023

PDF file - 232K, The supporting material describes in more detail the Markov chain model, and includes a full Table and two additional figures. Figure S1. Convergence plot for the lung cancer matrix. Figure S2. Metastatic tumor distributions after two-steps, compared with steady-state. Table S1. Comparative table of top two-step metastatic pathways of all types from Lung.
Supplementary Figure 2 from CD103 or LFA-1 Engagement at the Immune Synapse between Cytotoxic T Cells and Tumor Cells Promotes Maturation and Regulates T-cell Effector Functions
Authors: Franciszkiewicz Katarzyna , Le Floc'h Audrey , Boutet Marie , Vergnon Isabelle , Schmitt Alain , Mami-Chouaib Fathia
Published: April 2023

PDF file - 120K, Adhesion of T-cell clones to recombinant adhesion molecules under shear stress.
Supplementary Table 2 from Cell Surface Receptor FPR2 Promotes Antitumor Host Defense by Limiting M2 Polarization of Macrophages
Authors: Liu Ying , Chen Keqiang , Wang Chunyan , Gong Wanghua , Yoshimura Teizo , Liu Mingyong , Wang Ji Ming
Published: April 2023

PDF file - 61K, Gr1high and Gr1low cell subsets in mouse blood and spleen
Supplementary Figure 8 from Cell Surface Receptor FPR2 Promotes Antitumor Host Defense by Limiting M2 Polarization of Macrophages
Authors: Liu Ying , Chen Keqiang , Wang Chunyan , Gong Wanghua , Yoshimura Teizo , Liu Mingyong , Wang Ji Ming
Published: April 2023

PDF file - 113K, The expression of M1 macrophage markers
Supplementary Figure 6 from An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity
Authors: Williams Kevin J. , Argus Joseph P. , Zhu Yue , Wilks Moses Q. , Marbois Beth N. , York Autumn G. , Kidani Yoko , Pourzia Alexandra L. , Akhavan David , Lisiero Dominique N. , Komisopoulou Evangelia , Henkin Amy H. , Soto Horacio , Chamberlain Brian T. , Vergnes Laurent , Jung Michael E. , Torres Jorge Z. , Liau Linda M. , Christofk Heather R. , Prins Robert M. , Mischel Paul S. , Reue Karen , Graeber Thomas G. , Bensinger Steven J.
Published: April 2023

PDF File - 112K, Expression of mature SREBP1 alters the ratio of saturated to monounsaturated fatty acids.
Supplementary Figure 4 from An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity
Authors: Williams Kevin J. , Argus Joseph P. , Zhu Yue , Wilks Moses Q. , Marbois Beth N. , York Autumn G. , Kidani Yoko , Pourzia Alexandra L. , Akhavan David , Lisiero Dominique N. , Komisopoulou Evangelia , Henkin Amy H. , Soto Horacio , Chamberlain Brian T. , Vergnes Laurent , Jung Michael E. , Torres Jorge Z. , Liau Linda M. , Christofk Heather R. , Prins Robert M. , Mischel Paul S. , Reue Karen , Graeber Thomas G. , Bensinger Steven J.
Published: April 2023

PDF File - 92K, Cholesterol content is unchanged in SREBP loss-of-function cells.
Supplementary Figure 3 from An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity
Authors: Williams Kevin J. , Argus Joseph P. , Zhu Yue , Wilks Moses Q. , Marbois Beth N. , York Autumn G. , Kidani Yoko , Pourzia Alexandra L. , Akhavan David , Lisiero Dominique N. , Komisopoulou Evangelia , Henkin Amy H. , Soto Horacio , Chamberlain Brian T. , Vergnes Laurent , Jung Michael E. , Torres Jorge Z. , Liau Linda M. , Christofk Heather R. , Prins Robert M. , Mischel Paul S. , Reue Karen , Graeber Thomas G. , Bensinger Steven J.
Published: April 2023

PDF File - 52K, Cholesterol content is unchanged in SREBP loss-of-function cells.
Supplementary Figure 2 from An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity
Authors: Williams Kevin J. , Argus Joseph P. , Zhu Yue , Wilks Moses Q. , Marbois Beth N. , York Autumn G. , Kidani Yoko , Pourzia Alexandra L. , Akhavan David , Lisiero Dominique N. , Komisopoulou Evangelia , Henkin Amy H. , Soto Horacio , Chamberlain Brian T. , Vergnes Laurent , Jung Michael E. , Torres Jorge Z. , Liau Linda M. , Christofk Heather R. , Prins Robert M. , Mischel Paul S. , Reue Karen , Graeber Thomas G. , Bensinger Steven J.
Published: April 2023

PDF File - 155K, The lipogenic program and growth of glioma cells is SCAP sensitive.
Supplementary Figure 3 from Cell Surface Receptor FPR2 Promotes Antitumor Host Defense by Limiting M2 Polarization of Macrophages
Authors: Liu Ying , Chen Keqiang , Wang Chunyan , Gong Wanghua , Yoshimura Teizo , Liu Mingyong , Wang Ji Ming
Published: April 2023

PDF file - 93K, The expression of CCR4 by bone marrow cells
Supplementary Figure 2 from Cell Surface Receptor FPR2 Promotes Antitumor Host Defense by Limiting M2 Polarization of Macrophages
Authors: Liu Ying , Chen Keqiang , Wang Chunyan , Gong Wanghua , Yoshimura Teizo , Liu Mingyong , Wang Ji Ming
Published: April 2023

PDF file - 90K, Anti-CCL2 antibody specifically blocked CCL2- and LLC Sup-induced chemotaxis of WT mouse macrophages
Supplementary Figure 4 from Chemotherapy Acts as an Adjuvant to Convert the Tumor Microenvironment into a Highly Permissive State for Vaccination-Induced Antitumor Immunity
Authors: Kang Tae Heung , Mao Chih-Ping , Lee Sung Yong , Chen Alexander , Lee Ji-Hyun , Kim Tae Woo , Alvarez Ronald D. , Roden Richard B.S. , Pardoll Drew , Hung Chien-Fu , Wu T.-C.
Published: April 2023

PDF file - 1120K, Effect of chemotherapy on the phenotype of tumor-associated macrophages (TAMs)
Supplementary Tables 1 - 7 from Predictive Performance of Microarray Gene Signatures: Impact of Tumor Heterogeneity and Multiple Mechanisms of Drug Resistance
Authors: Ng Charlotte K.Y. , Weigelt Britta , A'Hern Roger , Bidard Francois-Clement , Lemetre Christophe , Swanton Charles , Shen Ronglai , Reis-Filho Jorge S.
Published: April 2023

PDF file - 108K, Impact of strength of the spiked-in gene expression changes on signature performance (S1); Performance of gene signatures according to the strength of the spiked-in gene expression changes (S2); Impact of distinct mechanisms of resistance on signatures generated using superPC (S3); Impact of signature strength on signature performance, when signatures are generated with SuperPC (S4); Impact of unevenly distributed but similarly prevalent resistance mechanisms in the training and test sets on signature performance (S5); Impact of different distributions of resistance mechanisms in training and test sets on signature performance (S6); Impact of overlapping gene signatures on signature performance (S7).
Supplementary Methods from Predictive Performance of Microarray Gene Signatures: Impact of Tumor Heterogeneity and Multiple Mechanisms of Drug Resistance
Authors: Ng Charlotte K.Y. , Weigelt Britta , A'Hern Roger , Bidard Francois-Clement , Lemetre Christophe , Swanton Charles , Shen Ronglai , Reis-Filho Jorge S.
Published: April 2023

PDF file - 33K, SUPPLEMENTARY R SCRIPT: R script and code that can be employed to generate all results described in the manuscript.
Supplementary Figure 1 from Bcl3 Selectively Promotes Metastasis of ERBB2-Driven Mammary Tumors
Authors: Wakefield Alison , Soukupova Jitka , Montagne Amelie , Ranger Jill , French Rhiannon , Muller William J. , Clarkson Richard W. E.
Published: April 2023

PDF file - 118K, Bcl3 expression is elevated in ErbB2 overexpressing human breast cancer cell lines
Supplementary Figures 1 - 5 from miR-483-5p Promotes Invasion and Metastasis of Lung Adenocarcinoma by Targeting RhoGDI1 and ALCAM
Authors: Song Qiancheng , Xu Yuanfei , Yang Cuilan , Chen Zhenguo , Jia Chunhong , Chen Juan , Zhang Yue , Lai Pinglin , Fan Xiaorong , Zhou Xuan , Lin Jun , Li Ming , Ma Wenli , Luo Shenqiu , Bai Xiaochun
Published: April 2023

PDF file - 488KB, Supplementary Figure 1. Upregulation of miR-483-5p is correlated with the progression of human lung adenocarcinoma. Supplementary Figure 2. miR-483-5p did not affect lung tumor growth in vitro and in vivo. Supplementary Figure 3. miR-483-5p, but not miR-483-3p promotes lung cancer cell EMT in vitro. Supplementary Figure 4. Identification of putative miR-483-5p target genes in A549 cells by 2D-DGE. Supplementary Figure 5. Knockdown of ALCAM did not affect the expression levels of the EMT-related proteins.
Supplementary Figure S2 from LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis
Authors: Cox Thomas R. , Bird Demelza , Baker Ann-Marie , Barker Holly E. , Ho Melisa W-Y. , Lang Georgina , Erler Janine T.
Published: April 2023

Supplementary Figure S2 PDF file - 171K, aSMA co-localisation during pulmonary fibrosis and LOX family member expression levels induced by liver fibrosis
Supplementary Figure S1 from LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis
Authors: Cox Thomas R. , Bird Demelza , Baker Ann-Marie , Barker Holly E. , Ho Melisa W-Y. , Lang Georgina , Erler Janine T.
Published: April 2023

Supplementary Figure S1 PDF file - 1024K, Co-expression of fibrotic markers and other LOX family members during pulmonary fibrosis
Supplementary Video 1 from Mechanisms Promoting Escape from Mitotic Stress–Induced Tumor Cell Death
Authors: Sinnott Rebecca , Winters Leah , Larson Brittany , Mytsa Daniela , Taus Patrick , Cappell Kathryn M. , Whitehurst Angelique W.
Published: April 2023

AVI - 127K, Video of a HCC366 micronucleated cell undergoing mitosis.
Supplementary Methods, Figure Legend from Genetic and Pharmacologic Inhibition of mTORC1 Promotes EMT by a TGF-β–Independent Mechanism
Authors: Mikaelian Ivan , Malek Mouhannad , Gadet Rudy , Viallet Jean , Garcia Amandine , Girard-Gagnepain Anaïs , Hesling Cédric , Gillet Germain , Gonzalo Philippe , Rimokh Ruth , Billaud Marc
Published: April 2023

PDF file - 91K
Supplementary Figure 5 from Genetic and Pharmacologic Inhibition of mTORC1 Promotes EMT by a TGF-β–Independent Mechanism
Authors: Mikaelian Ivan , Malek Mouhannad , Gadet Rudy , Viallet Jean , Garcia Amandine , Girard-Gagnepain Anaïs , Hesling Cédric , Gillet Germain , Gonzalo Philippe , Rimokh Ruth , Billaud Marc
Published: April 2023

PDF file - 741K, Supplementary Figure 5: Silencing of mTOR and RPTOR activates ZEB1 mRNA expression in various cell lines.
Supplementary Figures 1 - 6 from Aire Deficiency Promotes TRP-1–Specific Immune Rejection of Melanoma
Authors: Zhu Meng-Lei , Nagavalli Anil , Su Maureen A.
Published: April 2023

PDF file - 2957K, Supplementary Figure 1. Increased autoantibodies to B16 melanoma extract and decreased B16 melanoma growth in Aire-deficient mice. Supplementary Figure 2. Increased frequency of activated/memory T cells in Aire-deficient mice inoculated with B16 melanoma cells. Supplementary Figure 3. No change in T cell activation and cytokine secretion in AireGW/+ mice spleen and lymph nodes. Supplementary Figure 4. Reconstitution of T cells in B6 Nude mice transplanted with either WT or AireGW/+ thymi. Supplementary Figure 5. Defective negative selection of TRP-1 specific T cells in Aire-deficient bone marrow recipients. Supplementary Figure 6. Effects of Aire deficiency on TRP-1 Specific CD4+FOXP3+ Tregs in spleen
Supplementary Figure 1 from HNRNPAB Induces Epithelial–Mesenchymal Transition and Promotes Metastasis of Hepatocellular Carcinoma by Transcriptionally Activating SNAIL
Authors: Zhou Zheng-Jun , Dai Zhi , Zhou Shao-Lai , Hu Zhi-Qiang , Chen Qing , Zhao Yi-Ming , Shi Ying-Hong , Gao Qiang , Wu Wei-Zhong , Qiu Shuang-Jian , Zhou Jian , Fan Jia
Published: April 2023

PDF file - 964K, Supplementary Figure S1. The hnRNPAB expression in HCC cells and HCC samples.
Suppl Fig. S3 from Neuromedin U: A Candidate Biomarker and Therapeutic Target to Predict and Overcome Resistance to HER-Tyrosine Kinase Inhibitors
Authors: Rani Sweta , Corcoran Claire , Shiels Liam , Germano Serena , Breslin Susan , Madden Stephen , McDermott Martina S. , Browne Brigid C. , O'Donovan Norma , Crown John , Gogarty Martina , Byrne Annette T. , O'Driscoll Lorraine
Published: April 2023

Suppl Fig. S3
Supplementary Figure 6 from ΔNp63 Promotes Pediatric Neuroblastoma and Osteosarcoma by Regulating Tumor Angiogenesis
Authors: Bid Hemant K. , Roberts Ryan D. , Cam Maren , Audino Anthony , Kurmasheva Raushan T. , Lin Jiayuh , Houghton Peter J. , Cam Hakan
Published: April 2023

PDF file - 40K, Verification of IL-6 and IL-8 knockdown efficiency in SKNDZ and OS-17 cell lines.
Suppl Fig. S2 from Neuromedin U: A Candidate Biomarker and Therapeutic Target to Predict and Overcome Resistance to HER-Tyrosine Kinase Inhibitors
Authors: Rani Sweta , Corcoran Claire , Shiels Liam , Germano Serena , Breslin Susan , Madden Stephen , McDermott Martina S. , Browne Brigid C. , O'Donovan Norma , Crown John , Gogarty Martina , Byrne Annette T. , O'Driscoll Lorraine
Published: April 2023

Suppl Fig. S2
Supplementary Figure 3 from ΔNp63 Promotes Pediatric Neuroblastoma and Osteosarcoma by Regulating Tumor Angiogenesis
Authors: Bid Hemant K. , Roberts Ryan D. , Cam Maren , Audino Anthony , Kurmasheva Raushan T. , Lin Jiayuh , Houghton Peter J. , Cam Hakan
Published: April 2023

PDF file - 89K, Knockdown of endogenous deltaNp63 in neuroblastoma and osteosarcoma cell lines reduces cell proliferation and colony formation.
Supplementary Table 2 from Elimination of IL-10–Inducing T-Helper Epitopes from an IGFBP-2 Vaccine Ensures Potent Antitumor Activity
Authors: Cecil Denise L. , Holt Gregory E. , Park Kyong Hwa , Gad Ekram , Rastetter Lauren , Childs Jennifer , Higgins Doreen , Disis Mary L.
Published: April 2023

PDF file - 65KB, Bacterial sequence homologies for IGFBP-2 C-terminus.
Supplementary Table 1 from Elimination of IL-10–Inducing T-Helper Epitopes from an IGFBP-2 Vaccine Ensures Potent Antitumor Activity
Authors: Cecil Denise L. , Holt Gregory E. , Park Kyong Hwa , Gad Ekram , Rastetter Lauren , Childs Jennifer , Higgins Doreen , Disis Mary L.
Published: April 2023

PDF file - 15KB, Primer sequences and PCR conditions for the indicated construct.
Supplementary Figure Legends from CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic Cancer
Authors: Colbert Lauren E. , Petrova Aleksandra V. , Fisher Sarah B. , Pantazides Brooke G. , Madden Matthew Z. , Hardy Claire W. , Warren Matthew D. , Pan Yunfeng , Nagaraju Ganji P. , Liu Elaine A. , Saka Burcu , Hall William A. , Shelton Joseph W. , Gandhi Khanjan , Pauly Rini , Kowalski Jeanne , Kooby David A. , El-Rayes Bassel F. , Staley Charles A. , Adsay N. Volkan , Curran Walter J. , Landry Jerome C. , Maithel Shishir K. , Yu David S.
Published: April 2023

PDF file - 70KB
Supplementary Table 2 from CUL3 and NRF2 Mutations Confer an NRF2 Activation Phenotype in a Sporadic Form of Papillary Renal Cell Carcinoma
Authors: Ooi Aikseng , Dykema Karl , Ansari Asif , Petillo David , Snider John , Kahnoski Richard , Anema John , Craig David , Carpten John , Teh Bin-Tean , Furge Kyle A.
Published: April 2023

XLSX file - 5963K, Genes that are significantly deregulated (fdr < 0.1) in tumor tissue from Case-337 in relative to pooled normal kidney tissues
Supplementary Figure 4 from Mislocalization of the Cell Polarity Protein Scribble Promotes Mammary Tumorigenesis and Is Associated with Basal Breast Cancer
Authors: Feigin Michael E. , Akshinthala S. Dipikaa , Araki Kiyomi , Rosenberg Avi Z. , Muthuswamy Lakshmi B. , Martin Bernard , Lehmann Brian D. , Berman Hal K. , Pietenpol Jennifer A. , Cardiff Robert D. , Muthuswamy Senthil K.
Published: April 2023

PDF file - 103K, Mislocalization of SCRIB enhances EGF-induced AKT activation.
Supplementary Table 1 from CUL3 and NRF2 Mutations Confer an NRF2 Activation Phenotype in a Sporadic Form of Papillary Renal Cell Carcinoma
Authors: Ooi Aikseng , Dykema Karl , Ansari Asif , Petillo David , Snider John , Kahnoski Richard , Anema John , Craig David , Carpten John , Teh Bin-Tean , Furge Kyle A.
Published: April 2023

XLSX file - 186K, Somatic mutation in PRCC2
Supplementary Figure 6 from Nitroreductase, a Near-Infrared Reporter Platform for In Vivo Time-Domain Optical Imaging of Metastatic Cancer
Authors: McCormack Emmet , Silden Elisabeth , West Richard M. , Pavlin Tina , Micklem David R. , Lorens James B. , Haug Bengt Erik , Cooper Michael E. , Gjertsen Bjørn Tore
Published: April 2023

PDF file - 1949K, Flow cytometry quantification of NTR/CytoCy5S fluorescence in NB4 cells � NTR � CytoCy5S.
Supplementary Figure 2 from Nitroreductase, a Near-Infrared Reporter Platform for In Vivo Time-Domain Optical Imaging of Metastatic Cancer
Authors: McCormack Emmet , Silden Elisabeth , West Richard M. , Pavlin Tina , Micklem David R. , Lorens James B. , Haug Bengt Erik , Cooper Michael E. , Gjertsen Bjørn Tore
Published: April 2023

PDF file - 546K, In vitro characterization of NTR/CytoCy5S.
Supplementary Figure 5 from NADPH Oxidase NOX4 Supports Renal Tumorigenesis by Promoting the Expression and Nuclear Accumulation of HIF2α
Authors: Gregg Jennifer L. , Turner Robert M. , Chang Guimin , Joshi Disha , Zhan Ye , Chen Li , Maranchie Jodi K.
Published: April 2023

PDF file - 114K, Supplemental Figure 5 Cellular distribution of HIF-2alpha under normal oxygen conditions. (a) Representative confocal microscopy images (magnification 400x) showing HIF-2α or Nox4 immunofluorescense, DAPI nuclear staining, or merged images. b) Control (NS) or Nox4 shRNA (KD) cells were imaged following exposure to TEMPOL (0.25 mM), DTT (1mM). c) 786-0 NS cells imaged following transduction with Ad-GFP or Ad-MnSOD. d) 786-0 cells expressing pcDNA-Nox4 imaged with or without treatment with TEMPOL (0.25 mM).
Supplementary Figure 6 from Low PIP4K2B Expression in Human Breast Tumors Correlates with Reduced Patient Survival: A Role for PIP4K2B in the Regulation of E-Cadherin Expression
Authors: Keune Willem-Jan , Sims Andrew H. , Jones David R. , Bultsma Yvette , Lynch James T. , Jirström Karin , Landberg Goran , Divecha Nullin
Published: April 2023

PDF file - 46K, A. Lysates from MCF10A cells after 2 and 4 days of growth were analysed by western blotting using the antibodies shown. B. Lysates from cells treated as controls or with MG132 were analysed by western blotting with an anti-ubiquitin antibody to demonstrate that MG132 increases polyubiquitination of proteins.
Supplementary Figure 4 from NADPH Oxidase NOX4 Supports Renal Tumorigenesis by Promoting the Expression and Nuclear Accumulation of HIF2α
Authors: Gregg Jennifer L. , Turner Robert M. , Chang Guimin , Joshi Disha , Zhan Ye , Chen Li , Maranchie Jodi K.
Published: April 2023

PDF file - 183K, Supplemental Figure 4. Cytotoxicity was measured by CellTiter-Blue (Promega, Madison, WI). 786-0 NS cells were plated at 1 x 104 cells per well in 96-well plates. After 24 hours, dithiothreitol was added as indicated in 5 replicate wells. 20 �l of the CellTiter-Blue reagent was added to each well and viability quantitated by spectrofluorometer (Spectra Max Plus384, Molecular Devices) and expressed as percentage of viability of media-only controls. Error bars indicate +/- S.E. mean.
Supplementary Figures 1-7, Table 1 from Androgen Receptor Splice Variants Mediate Enzalutamide Resistance in Castration-Resistant Prostate Cancer Cell Lines
Authors: Li Yingming , Chan Siu Chiu , Brand Lucas J. , Hwang Tae Hyun , Silverstein Kevin A.T. , Dehm Scott M.
Published: April 2023

PDF file - 654K, Supplementary Figure 1: Antiandrogens achieve on-target inhibition of full-length AR in 22Rv1 cells Supplementary Figure 2: CWR-R1 cells harboring a 48kb intragenic deletion in AR intron 1 display androgen-independent growth Supplementary Figure 3: Deletion-enriched CWR-R1 cells are resistant to full-length AR targeting Supplementary Figure 4: AKT1 is not an AR-V target in deletion-enriched CWR-R1 cells Supplementary Figure 5: Western blots from biological replicates for microarray analysis with Illumina Beadchips Supplementary Figure 6: Gene networks identified from androgen/AR and AR-V gene lists using Ingeniuty Systems Pathway Analysis Supplementary Figure 7: Gene set enrichment analysis (GSEA) of full-length androgen/AR-specific gene signatures in LNCaP cells Supplementary Table 1: Androgen/AR and AR-V gene lists
Supplementary Figure 7 from Redox Modulation of Adjacent Thiols in VLA-4 by AS101 Converts Myeloid Leukemia Cells from a Drug-Resistant to Drug-Sensitive State
Authors: Layani-Bazar Adi , Skornick Itai , Berrebi Alain , Pauker Maor H. , Noy Elad , Silberman Alon , Albeck Michael , Longo Dan L. , Kalechman Yona , Sredni Benjamin
Published: April 2023

PDF file - 1142K, Fig S7. Treatment with AS101 prevents MRD in a xenograft mouse model of AML.
Supplementary Table 2 from A Circadian Clock Transcription Model for the Personalization of Cancer Chronotherapy
Authors: Li Xiao-Mei , Mohammad-Djafari Ali , Dumitru Mircea , Dulong Sandrine , Filipski Elisabeth , Siffroi-Fernandez Sandrine , Mteyrek Ali , Scaglione Francesco , Guettier Catherine , Delaunay Franck , Lévi Francis
Published: April 2023

PDF file - 78K, Plasma pharmacokinetic parameters (Mean plus/minus SEM) of irinotecan according to timing and chronotoxicity classes.
Supplementary Figures 1 - 5 from High-Throughput Tyrosine Kinase Activity Profiling Identifies FAK as a Candidate Therapeutic Target in Ewing Sarcoma
Authors: Crompton Brian D. , Carlton Anne L. , Thorner Aaron R. , Christie Amanda L. , Du Jinyan , Calicchio Monica L. , Rivera Miguel N. , Fleming Mark D. , Kohl Nancy E. , Kung Andrew L. , Stegmaier Kimberly
Published: April 2023

PDF file - 62K, Treatment of two Ewing sarcoma cell lines with A, dasatinib (SRC inhibitor) for 8 hours or B, PD0325901 (MEK inhibitor) for 72 hours eliminates phosphorylation of SRC and ERK, respectively (S1); Transduction with five FAK-directed shRNAs downregulate FAK expression compared to a control shRNA in the A673 Ewing sarcoma cell line (S2); Treatment of A673 and TC32 Ewing sarcoma cell lines with PF-562271 reduced cell growth (S3); Treatment of Ewing sarcoma cell lines with PF- 562271 impairs cell growth (S4); PYK2 is variably expressed in Ewing sarcoma cell lines (S5).
Supplementary Table 1 from Human Rhomboid Family-1 Suppresses Oxygen-Independent Degradation of Hypoxia-Inducible Factor-1α in Breast Cancer
Authors: Zhou Zhuan , Liu Fangfang , Zhang Zhi-Song , Shu Feifei , Zheng Yangyang , Fu Li , Li Lu-Yuan
Published: April 2023

PDF file - 93KB, RHBDF1 expression and clinicopathological features of invasive breast cancer (IBC).
Supplementary Table 4 from Transcriptional Profiling of Melanoma Sentinel Nodes Identify Patients with Poor Outcome and Reveal an Association of CD30+ T Lymphocytes with Progression
Authors: Vallacchi Viviana , Vergani Elisabetta , Camisaschi Chiara , Deho Paola , Cabras Antonello D. , Sensi Marialuisa , De Cecco Loris , Bassani Niccolò , Ambrogi Federico , Carbone Antonino , Crippa Federica , Vergani Barbara , Frati Paola , Arienti Flavio , Patuzzo Roberto , Villa Antonello , Biganzoli Elia , Canevari Silvana , Santinami Mario , Castelli Chiara , Rivoltini Licia , Rodolfo Monica
Published: April 2023

XLSX file - 198K, Supplementary Table S4. Genes found to be differentially expressed between the PP and the PN samples, as confirmed by qPCR.
Supplementary Table 3 from Transcriptional Profiling of Melanoma Sentinel Nodes Identify Patients with Poor Outcome and Reveal an Association of CD30+ T Lymphocytes with Progression
Authors: Vallacchi Viviana , Vergani Elisabetta , Camisaschi Chiara , Deho Paola , Cabras Antonello D. , Sensi Marialuisa , De Cecco Loris , Bassani Niccolò , Ambrogi Federico , Carbone Antonino , Crippa Federica , Vergani Barbara , Frati Paola , Arienti Flavio , Patuzzo Roberto , Villa Antonello , Biganzoli Elia , Canevari Silvana , Santinami Mario , Castelli Chiara , Rivoltini Licia , Rodolfo Monica
Published: April 2023

XLSX file - 202K, Supplementary Table S3. Results generated by GSEA comparing the PN and the PP samples.
Supplementary Figure 6 from Skin Tumorigenesis Stimulated by Raf Inhibitors Relies Upon Raf Functions That Are Dependent and Independent of ERK
Authors: Doma Eszter , Rupp Christian , Varga Andrea , Kern Florian , Riegler Bettina , Baccarini Manuela
Published: April 2023

PDF file - 305K, Regression of inhibitor‐induced SOS‐F+ tumors upon discontinuation of drug treatment.
Supplementary Figure 3 from Transcriptional Profiling of Melanoma Sentinel Nodes Identify Patients with Poor Outcome and Reveal an Association of CD30+ T Lymphocytes with Progression
Authors: Vallacchi Viviana , Vergani Elisabetta , Camisaschi Chiara , Deho Paola , Cabras Antonello D. , Sensi Marialuisa , De Cecco Loris , Bassani Niccolò , Ambrogi Federico , Carbone Antonino , Crippa Federica , Vergani Barbara , Frati Paola , Arienti Flavio , Patuzzo Roberto , Villa Antonello , Biganzoli Elia , Canevari Silvana , Santinami Mario , Castelli Chiara , Rivoltini Licia , Rodolfo Monica
Published: April 2023

PDF file - 107K, Supplementary Figure S3.Comparative gene expression analysis by qRT-PCR of the genes that were differently expressed between the PP and the PN groups. A. Genes upregulated in the PP samples (DEFA1, IL17B, and CST6) (p<0.05). B. Genes upregulated in the PN samples (CD68, MUM1, and ADAM22) (p<0.05). The graphs display the results obtained using the training and validation samples. The relative quantification for each sample was determined using 2-DCt, and RPL13A was used as an internal reference.
Supplementary Movie 1A from Curcumin Targets Breast Cancer Stem–like Cells with Microtentacles That Persist in Mammospheres and Promote Reattachment
Authors: Charpentier Monica S. , Whipple Rebecca A. , Vitolo Michele I. , Boggs Amanda E. , Slovic Jana , Thompson Keyata N. , Bhandary Lekhana , Martin Stuart S.
Published: April 2023

AVI file - 1306K, Live cell confocal imaging of a HMLE mammosphere stained with CellMask Orange revealing dynamic microtentacles.
Supplementary Table 1 from A Rare Polymorphic Variant of NBS1 Reduces DNA Repair Activity and Elevates Chromosomal Instability
Authors: Yamamoto Yuki , Miyamoto Mamiko , Tatsuda Daisuke , Kubo Michiaki , Nakagama Hitoshi , Nakamura Yusuke , Satoh Hitoshi , Matsuda Koichi , Watanabe Toshiki , Ohta Tsutomu
Published: April 2023

PDF file - 55KB, Characteristics of study population.
Supplementary Figure 2 from A Rare Polymorphic Variant of NBS1 Reduces DNA Repair Activity and Elevates Chromosomal Instability
Authors: Yamamoto Yuki , Miyamoto Mamiko , Tatsuda Daisuke , Kubo Michiaki , Nakagama Hitoshi , Nakamura Yusuke , Satoh Hitoshi , Matsuda Koichi , Watanabe Toshiki , Ohta Tsutomu
Published: April 2023

PDF file - 302KB, Survival in response to AZD2281 and cell cycle arrest in other cells expressing an NBS1-I171V polymorphic variant.
Supplementary Figure 1 from A Rare Polymorphic Variant of NBS1 Reduces DNA Repair Activity and Elevates Chromosomal Instability
Authors: Yamamoto Yuki , Miyamoto Mamiko , Tatsuda Daisuke , Kubo Michiaki , Nakagama Hitoshi , Nakamura Yusuke , Satoh Hitoshi , Matsuda Koichi , Watanabe Toshiki , Ohta Tsutomu
Published: April 2023

PDF file - 191KB, Reduced DSB repair activity in other cells expressing an NBS1-I171V polymorphic variant.
Supplementary Figure 8 from Metastasis Suppressor KISS1 Seems to Reverse the Warburg Effect by Enhancing Mitochondrial Biogenesis
Authors: Liu Wen , Beck Benjamin H. , Vaidya Kedar S. , Nash Kevin T. , Feeley Kyle P. , Ballinger Scott W. , Pounds Keke M. , Denning Warren L. , Diers Anne R. , Landar Aimee , Dhar Animesh , Iwakuma Tomoo , Welch Danny R.
Published: April 2023

PDF file - 2389K, Supplemental Figure 8. C8161.9 cell growth depends upon glucose, but not glutamine. C8161.9Vector (V), C8161.9KFMΔSS, C8161.9KFM and C8161.9KFM/shPGC1α (KFM shP) cells were cultured in 0.1% fetal bovine serum-containing DMEM in the presence (+) or absence (-) of glucose or L-glutamine for 10 days. Representative images of the cell cultures are shown.
Supplementary Figure 5 from Metastasis Suppressor KISS1 Seems to Reverse the Warburg Effect by Enhancing Mitochondrial Biogenesis
Authors: Liu Wen , Beck Benjamin H. , Vaidya Kedar S. , Nash Kevin T. , Feeley Kyle P. , Ballinger Scott W. , Pounds Keke M. , Denning Warren L. , Diers Anne R. , Landar Aimee , Dhar Animesh , Iwakuma Tomoo , Welch Danny R.
Published: April 2023

PDF file - 753K, Supplemental Figure 5. Knocking down PGC1alpha expression abolished KISS1-mediated increase of mitochondria gene expression. The expression of mtTFA, , MT-ND2, MT-RNR2 and nuclear encoded mitochondria genes AIFM2, RHOT1 and TIMM8 in C8161.9Vector (V), C8161.9KFM (P), and C8161.9KFMshPGC1alpha (clones 1-1 and 1-2) were examined by qRT-PCR. Values are mean plus-minus SD of triplicate measurements. P values are based upon a two-sided Student's T-test.
Supplementary Figure 4 from Metastasis Suppressor KISS1 Seems to Reverse the Warburg Effect by Enhancing Mitochondrial Biogenesis
Authors: Liu Wen , Beck Benjamin H. , Vaidya Kedar S. , Nash Kevin T. , Feeley Kyle P. , Ballinger Scott W. , Pounds Keke M. , Denning Warren L. , Diers Anne R. , Landar Aimee , Dhar Animesh , Iwakuma Tomoo , Welch Danny R.
Published: April 2023

PDF file - 968K, Supplemental Figure 4. KISS1 differentially regualtes PGC1alpha downstream of lipid signals. Expression of genes in lipogenesis and β-oxidation in C8161.9Vector (V), C8161.9KFMΔSS and C8161.9KFM (KFM clones 59 and 17 are shown), C8161.9KFM/shKiss1 (clones IA1, IA4 and IE4) cells were examined by by qRT-PCR. Values are means plus-minus SD of triplicate measurements. P values are based on a two-sided Student's test.
Supplementary Figure 1 from Attenuation of microRNA-126 Expression That Drives CD34+38− Stem/Progenitor Cells in Acute Myeloid Leukemia Leads to Tumor Eradication
Authors: de Leeuw David C. , Denkers Fedor , Olthof Marjolein C. , Rutten Arjo P. , Pouwels Walter , Jan Schuurhuis Gerrit , Ossenkoppele Gert J. , Smit Linda
Published: April 2023

PDF file - 93KB, Validation of microarray by qRT-PCR: Surplus RNA from LSC and progenitor populations that remained after array hybridization was used for the validation of the microarray results. MicroRNA expression analysis was performed by qRT-PCR using microRNA specific primers and RNU48 as internal control. Fold change was calculated using ddCT-method. qRT-PCR validated the results obtained from microarray analysis. CD34+CD38- LSC show higher expression of miR-22, miR-126, miR-150, miR-335 and lower expression of miR-886-3p compared to CD34+CD38+ leukemic progenitors. Blue bars, LSC; Red bars, leukemic progenitors.
Supplementary Figure 2 from Metastasis Suppressor KISS1 Seems to Reverse the Warburg Effect by Enhancing Mitochondrial Biogenesis
Authors: Liu Wen , Beck Benjamin H. , Vaidya Kedar S. , Nash Kevin T. , Feeley Kyle P. , Ballinger Scott W. , Pounds Keke M. , Denning Warren L. , Diers Anne R. , Landar Aimee , Dhar Animesh , Iwakuma Tomoo , Welch Danny R.
Published: April 2023

PDF file - 1288K, Supplemental Figure 2. A, Conditioned media from C8161.9KFM but not C8161.9 cells downregulates vATPase expression. C8161.9Vector cells were treated with conditioned media collected from C8161.9Vector , C8161.9KFM, and C8161.9 cells for 24 hours. The expression of v-ATPase subunit V0D2 and V1G3 in C8161.9Vector, C8161.9KFM, and C8161.9 cells were then examined by qRT-PCR. Values are means plus-minus SD of triplicate measurements. P values are based on a twosided Student's test. B, Transcript levels of apoptotic genes (BNIP3 and ATG5) and glycolytic genes (GLUT1, HKII, PFK1) were examined by qRT-PCR in C8161.9Vector (V), C8161.9KFMdeltaSS (D) and C8161.9KFM (K) cells treated with bafilomycin (10 nM; 24 hr). Values are mean plus-minus standard deviation for triplicate samples. P values are based upon two-sided Student's T-test (*, p<0.05; **, p<0.01; ***, p<0.001).
Supplementary Figure 1 from Metastasis Suppressor KISS1 Seems to Reverse the Warburg Effect by Enhancing Mitochondrial Biogenesis
Authors: Liu Wen , Beck Benjamin H. , Vaidya Kedar S. , Nash Kevin T. , Feeley Kyle P. , Ballinger Scott W. , Pounds Keke M. , Denning Warren L. , Diers Anne R. , Landar Aimee , Dhar Animesh , Iwakuma Tomoo , Welch Danny R.
Published: April 2023

PDF file - 1136K, Supplemental Figure 1. Glycolytic enzyme expression in KISS1-expressing cells. Transcript level of glucose transporter (GLUT1) and several glycolytic enzymes (HKII, PFK1, PKM1, PKM2, LDHA and LDHB) were examined by qRT-PCR in C8161.9Vector (V), C8161.9KFMdeltaSS (D) and C8161.9KFM (K) as well as MelJuSoVector (V) and MelJuSoKFM (K) cells. Values are mean plus-minus standard deviation of three independent experiments. P values are based on a two-sided Student's T-test (*, p<0.05; **, p<0.01; ***, p<0.001).
Supplementary Methods from Mesenchymal Stem Cells Use IDO to Regulate Immunity in Tumor Microenvironment
Authors: Ling Weifang , Zhang Jimin , Yuan Zengrong , Ren Guangwen , Zhang Liying , Chen Xiaodong , Rabson Arnold B. , Roberts Arthur I. , Wang Ying , Shi Yufang
Published: April 2023

PDF file - 135KB
Supplementary Methods from Intratumoral Modeling of Gefitinib Pharmacokinetics and Pharmacodynamics in an Orthotopic Mouse Model of Glioblastoma
Authors: Sharma Jyoti , Lv Hua , Gallo James M.
Published: April 2023

PDF file - 139K
Supplementary Table 5 from Genome-wide Profiling of Genetic Synthetic Lethality Identifies CDK12 as a Novel Determinant of PARP1/2 Inhibitor Sensitivity
Authors: Bajrami Ilirjana , Frankum Jessica R. , Konde Asha , Miller Rowan E. , Rehman Farah L. , Brough Rachel , Campbell James , Sims David , Rafiq Rumana , Hooper Sean , Chen Lina , Kozarewa Iwanka , Assiotis Ioannis , Fenwick Kerry , Natrajan Rachael , Lord Christopher J. , Ashworth Alan
Published: April 2023

PDF file 54K, Supplementary Table S5. Tumor-specific CDK12 mutations described in publically available sequencing data
Supplementary Table 1 - 3 from Targeting a Glioblastoma Cancer Stem-Cell Population Defined by EGF Receptor Variant III
Authors: Emlet David R. , Gupta Puja , Holgado-Madruga Marina , Del Vecchio Catherine A. , Mitra Siddhartha S. , Han Shuang-Yin , Li Gordon , Jensen Kristin C. , Vogel Hannes , Xu Linda Wei , Skirboll Stephen S. , Wong Albert J.
Published: April 2023

PDF file - 82K, GBM Patient Data (S1); EGFRvIII and CD133 expression in GBM Neurospheres or Normal Brain (NB) derived Neurospheres (S2); Percentage of co-localization of EGFRvIII+ with Markers of Differentiation and Stem/Progenitor Cells (S3).
Supplementary Figures 1 - 5 from Targeting a Glioblastoma Cancer Stem-Cell Population Defined by EGF Receptor Variant III
Authors: Emlet David R. , Gupta Puja , Holgado-Madruga Marina , Del Vecchio Catherine A. , Mitra Siddhartha S. , Han Shuang-Yin , Li Gordon , Jensen Kristin C. , Vogel Hannes , Xu Linda Wei , Skirboll Stephen S. , Wong Albert J.
Published: April 2023

PDF file - 3725K, Gating Tree for Fluorescence Activated Cell Sorting (FACS) Analysis (S1); Vessel Staining of EGFRvIII in GBM Xenografts (S2); Characterization and Affinity Analysis of the Recombinant Antibodies (S3); Antibody Dependent Cellular Cytotoxicity Induced by BsAb (S4); Limiting Dilution Analysis of Unsorted Tumor Spheres Before and After BsAb Induced ADCC (S5).
Supplementary Table 1 from Genome-wide Profiling of Genetic Synthetic Lethality Identifies CDK12 as a Novel Determinant of PARP1/2 Inhibitor Sensitivity
Authors: Bajrami Ilirjana , Frankum Jessica R. , Konde Asha , Miller Rowan E. , Rehman Farah L. , Brough Rachel , Campbell James , Sims David , Rafiq Rumana , Hooper Sean , Chen Lina , Kozarewa Iwanka , Assiotis Ioannis , Fenwick Kerry , Natrajan Rachael , Lord Christopher J. , Ashworth Alan
Published: April 2023

PDF file 32K, Supplementary Table S1 Antibody reagent list used in study
Supplementary Information from Genome-wide Profiling of Genetic Synthetic Lethality Identifies CDK12 as a Novel Determinant of PARP1/2 Inhibitor Sensitivity
Authors: Bajrami Ilirjana , Frankum Jessica R. , Konde Asha , Miller Rowan E. , Rehman Farah L. , Brough Rachel , Campbell James , Sims David , Rafiq Rumana , Hooper Sean , Chen Lina , Kozarewa Iwanka , Assiotis Ioannis , Fenwick Kerry , Natrajan Rachael , Lord Christopher J. , Ashworth Alan
Published: April 2023

PDF file 120K, Supplementary figure legends and supplementary materials and methods
Supplementary Table 2 from Inhibitor-Sensitive FGFR2 and FGFR3 Mutations in Lung Squamous Cell Carcinoma
Authors: Liao Rachel G. , Jung Joonil , Tchaicha Jeremy , Wilkerson Matthew D. , Sivachenko Andrey , Beauchamp Ellen M. , Liu Qingsong , Pugh Trevor J. , Pedamallu Chandra Sekhar , Hayes D. Neil , Gray Nathanael S. , Getz Gad , Wong Kwok-Kin , Haddad Robert I. , Meyerson Matthew , Hammerman Peter S.
Published: April 2023

PDF file - 74K, FGFR inhibitors profiled in this study.
Supplementary Figure 6 from Inhibitor-Sensitive FGFR2 and FGFR3 Mutations in Lung Squamous Cell Carcinoma
Authors: Liao Rachel G. , Jung Joonil , Tchaicha Jeremy , Wilkerson Matthew D. , Sivachenko Andrey , Beauchamp Ellen M. , Liu Qingsong , Pugh Trevor J. , Pedamallu Chandra Sekhar , Hayes D. Neil , Gray Nathanael S. , Getz Gad , Wong Kwok-Kin , Haddad Robert I. , Meyerson Matthew , Hammerman Peter S.
Published: April 2023

PDF file - 147K, FGFR2-P253R functional data.
Supplementary Figure 4 from Inhibitor-Sensitive FGFR2 and FGFR3 Mutations in Lung Squamous Cell Carcinoma
Authors: Liao Rachel G. , Jung Joonil , Tchaicha Jeremy , Wilkerson Matthew D. , Sivachenko Andrey , Beauchamp Ellen M. , Liu Qingsong , Pugh Trevor J. , Pedamallu Chandra Sekhar , Hayes D. Neil , Gray Nathanael S. , Getz Gad , Wong Kwok-Kin , Haddad Robert I. , Meyerson Matthew , Hammerman Peter S.
Published: April 2023

PDF file - 414K, BGJ398, dovitinib, and pazopanib soft agar and western blot data.