bluuebunny/crossref_metadata_2025 huggingface dataset:
Gestational and age-specific cystatin C reference intervals for newborns in China
Authors: Tong Chao , Liu Yalan , Wu Yanqiu , Li Qiong , Wu Yipin , Wang Lin , Chen Yan
Published: December 2019

Backgroud : To establish reference values of serum cystatin C (CysC) in Chinese newborn infants. Methods: Serum CysC levels were measured in 1919 blood samples from 1044 newborns during their first 28 days of life. CysC levels were analyzed for association between subgroups dichotomized by postnatal age (PA) and gestational age (GA). Reference intervals of serum CysC were determined according to the PA and GA. The association between serum CysC level and other biochemical parameters as well as perinatal factors were also analyzed. Results: In this study, the mean GA was 35.75±2.90 weeks and birth weight was 2613.77±696.72 g. Reference ranges of serum CysC were determined and a general decreasing trend of CysC levels was observed as GA increased. CysC levels differed significantly among the PA and GA groups (P＜0.001). Serum CysC levels were relatively stable throughout GA, except being impacted by white blood cell count within postnatal 24 hours. Moreover, their levels always correlated positively with serum creatinine concentrations (P<0.001). Conclusion: The reference level of serum CysC should be determined according to PA and GA. In contrast to creatinine, serum CysC is a dependable index for assessing renal function in neonate, for there are rare factors influencing it.
Overexpression of immune-responsive gene 1 prevents acute otitis media due to streptococcus pneumoniae infection through Nrf2- Hmox1 pathway
Authors: Yang Peizhen , Li Yufen , Wang Dongqing , Chen Zhipeng
Published: December 2019

Background: Acute otitis media (AOM) is one of the most commonly diagnosed childhood diseases that are associated with influenza infection. Immunoresponsive gene 1 (Irg1) is overexpressed in mammalian macrophage during inflammation process. Here, the present study aims to investigate the role of Irg1 in streptococcus pneumoniae infection-induced inflammatory response in AOM through Nrf2 signaling pathway. Methods: Positive rate of streptococcus pneumoniae and expression of Irg1, Nrf2 and Hmox1 were determined in the middle ear lavage fluid from 85 AOM patients infected with streptococcus pneumoniae and 48 healthy subjects. After the successful establishment of mice model with AOM, macrophage was harvest from the middle ear lavage fluid of mice. At last, to investigate the effect of Irg1 and Nrf2 signaling pathway on inflammatory response and streptococcus pneumoniae infection by accumulating macrophage, Irg1, sh-Irg1 and retinoic acid (an inhibitor of Nrf2 signaling pathway) were injected into AOM mice. Results: Irg1 exhibited a high level and activated Nrf2 signaling pathway was detected in AOM. Besides, positive rate of streptococcus pneumoniae was increased in AOM. Furthermore, in the mice model with AOM, Irg1 could repress inflammatory response by downregulating expression of TNF-α, IL-6 and IL-1β and inhibit streptococcus pneumoniae infection by stimulating accumulation of macrophage to increase its endocytosis through activation of Nrf2 signaling pathway. Conclusion: Taken together, Irg1 contributes to inhibiting inflammatory response and streptococcus pneumoniae infection in AOM by promoting accumulation of macrophage through activation of Nrf2 signaling pathway, which provides novel therapeutic targets for AOM therapy.
Peri-treatment peripheral blood cell score predicts long-term locoregional progression hazard in oesophageal squamous cell carcinoma after definitive chemoradiotherapy
Authors: Chen Jianzhou , Xu Liangyu , Guo Hong , Huang Ruihong , Guo Longjia , Yu Yuanxiang , Zhai Tiantian , Wu Fangcai , Chen Zhijian , Li Derui , Chen ChuangZhen
Published: December 2019

Background Prediction of response to chemoradiotherapy is critical for the optimal management of oesophageal cancer, yet it is still an unmet clinical need. This study aims to evaluate the predictive potential of peri-treatment peripheral blood cells (PBC) in disease progression hazard in oesophageal cancer following chemoradiotherapy.Methods 87 patients with primary oesophageal squamous cell carcinoma were subjected to definitive concurrent chemoradiotherapy in a phase II trial. PBC parameters (haemoglobin, neutrophils, platelets, lymphocytes and monocytes) were collected at 7 time points through the course of radiotherapy. The values of peri-treatment PBC parameters in predicting 3-year cumulative hazard of tumour progression were evaluated.Results Patients with disease progression displayed distinct distribution patterns of peri-treatment PBC compared to patients without. Greater prediction capabilities for risk of locoregional disease progression were found in PBC collected after the start of radiotherapy compared to their pretreatment counterparts, and in individual parameters rather than cell-to-cell ratios. The most predictive PBC parameters were integrated by summation and designated as a PBC score (PBCS), which further augmented their predictive power. Patients divided according to their PBCS (high vs medium vs low) had significantly different 3-year cumulative hazards of locoregional progression (58% vs 29% vs 7%, P = 0.0017). Multivariate analysis confirmed that PBCS high (HR 12.2, 95%CI 2.0-76.3, P = 0.007) and medium (HR 5.8, 95%CI 1.2-27.7, P = 0.028) are independent indicators of locoregional progression.Conclusion Peri-treatment PBCS can predict the long-term hazard of locoregional progression after definitive chemoradiotherapy in patients with oesophageal squamous cell carcinoma.
Catalytic hydrolysis of Dichlorodifluoromethane over MoO3/ZrO2 -TiO2 solid acid
Authors: Li Zhiqian , Zhou Tong , Ren Guoqing , Tan Xiaofang , Jia Lijuan , Liu Tiancheng
Published: December 2019

The catalytic behaviors of solid acid of MoO3/ZrO2-TiO2 calcined at different temperature for the catalytic hydrolysis of Dichlorodifluoromethane have been studided. The effects of catalytic hydrolysis temperature and water vapor concentration on catalytic hydrolysis of Dichlorodifluoromethane were also studied. The Results show 98.65 % of Dichlorodifluoromethane is degraded over MoO3/ZrO2-TiO2 catalyst calcined at 500 ℃ with a concentration of water vapor of 83.18% when the hydrolysis temperature is 400。C and the Dichlorodifluoromethane flux rate is 1mL/min with main degradation products were CO, CO2, HF and HCl. A maintained degradation rate of 65.34 % of Difluoromethylene Chloride has been observed through 30 hours’ continuous reaction over the catalyst of MoO3/ZrO2-TiO2. The XRD result reveals the main phase of solid MoO3/ZrO2-TiO2 catalyst is the tetragonal Zr(MoO4)2 that doped TiO2 of anatase.
Association of Chinese sauerkraut consumption with esophageal cancer in Chinese populations: A meta-analysis
Authors: Han Dan , Liu Shuang , Liang Kaige , huang yaojiang
Published: December 2019

Background With accumulating evidence showing that Chinese sauerkraut consumption may be associated with the developmental of Esophageal cancer.Objective We carried out a analysis by R to Evaluate whether the consumption of Chinese sauerkraut is associated with Esophageal cancer in Chinese populations.Methods Two independent investigators carry out a systematic search through Oct 8, 2019 for all studies. The search terms included Chinese sauerkraut, Chinese pickled vegetable, and Suancai, in combination with Esophageal cancer. Investigators extracted, pooled and analysed data from the included studies using a random-effects model in R.Results A random-effects meta-analysis of all 23 studies, including 32,259 unique participants, indicated that Chinese sauerkraut consumption is associated with a significantly increased risk of Esophageal cancer compared to controls (OR=1.81, 95% CI=1.50-2.19, P=0.00001). Sensitivity analysis showed that no single study significantly influenced the overall association. Most of the subgroup analyses, including those of subtype of EC, geographic area, publication language and year, demonstrated a statistically significant association between consuming Chinese sauerkraut and Esophageal cancer risk. Meta-regression indicated that gender and publication year is positively correlated with effect sizes. Furthermore, the trim-and-fill method used to adjust for funnel plot asymmetry in our meta-analysis confirmed that a positive outcome is unlikely to be due to publication bias.Conclusion The results of this meta-analysis provide evidence that consuming Chinese sauerkraut may increase the risk of Esophageal cancer.
Diagnostic performance of nucleic acid tests in tuberculous pleurisy
Authors: Xiao He-ping , Yan Liping , Han Min
Published: December 2019

Background: Tuberculous pleurisy (TBP) is the most common form of extrapulmonary tuberculosis (TB). However, rapid diagnostic methods with high accuracy for tuberculous pleurisy are urgently needed. In the present study, we evaluated the diagnostic accuracy of Xpert MTB/RIF, LAMP and SAT-TB assay with pleural fluids from from culture-positive TBP patients. Methods: We prospectively enrolled 300 patients with exudative pleural effusions used as the samples for Xpert MTB/RIF, LAMP and SAT-TB assay. Of these, 265 including 223 patients diagnosed with TP and 42 non-TB patients used as controls were analyzed. Results: The sensitivities of Xpert MTB/RIF (27.4%) , LAMP (26.5%) and SAT-TB assay (32.3%) were significantly higher than that of pleural effusion smear (14.3% , X2 = 20.65, P < 0.001), whereas they were much lower than expected for the analysis of pleural effusion samples. Both SAT-TB assay and Xpert MTB/RIF demonstrated high specificities (100%) and PPVs (100%), but the NPVs of all of the tests were < 22%. The area under ROC curve of pleural effusion smear, LAMP, Xpert MTB/RIF and SAT-TB assays was 0.524 (95% CI 0.431–0.617), 0.632 (95% CI 0.553–0.71), 0.637 (95% CI 0.56–0.714) and 0.673 (95% CI 0.6–0.745). SAT-TB assays had the highest AUC. Conclusion: Nucleic acid amplification tests are not the first choice in the diagnosis of tuberculous pleurisy. In this type of test, SAT-TB is recommended because of its low cost, relatively more accurate compared with the other two tests. This prospective study was approved by The Ethics Committee of the Shanghai Pulmonary Hospital (approval number: K19-148). ClinicalTrials.gov identifier: ChiCTR1900026234.
Palliative nasogastric tube placement for patients with advanced esophageal cancer with nearly total obstruction: Consider the feasibility and acceptability considerations
Authors: YANG CHIH WEI , Huang I-Hsuan , Chang Wei-Kuo
Published: December 2019

Background: Nasogastric tube (NGT) feeding was reasonable choice for patients with advanced esophageal cancer with a short-life expectancy. Bedside blind NGT placement beyond the nearly total obstruction lesion usually fail and is challenging. Each individual patient might have different cancer stage, tumor location and size, natural course of the disease, technique feasibility, and tolerability of NGT placement. This study evaluates the benefits and limitations of palliative NGT placements for advanced esophageal cancer during their last months of life. Method: Retrospective observation study was performed. We implemented three techniques of palliative NGT placement, compared the advantages and limitations, and evaluated the clinical outcomes in patients advanced esophageal cancer with nearly total obstruction. The present study was performed in at a tertiary care teaching hospital, Taiwan. Patients (n =32) received palliative care, failure of bedside blind NGT placement, and/or NPO (Nil per os) treatment were included. Patients were divided into different palliative NGT placements: guidewire method (n = 6), the drag method (n = 6), push method (n = 10). Results: Success rate of palliative NGT placement was observed in the guidewire method (75%), drag method, (100%), and push method (93%). Compared the palliative NGT groups to NPO group, NGT groups had significantly increased in enteral caloric intake (p < 0.05), serum albumin level (p < 0.01), decreased the length of hospital stay (p = 0.01), but increased the survival time (p = 0.01). Conclusion: Patients who tolerated the NGT placement will able to receive desired caloric intake, decrease length of hospital stay, and increase the overall survival time.
Evidence for an ancient bilaterian origin of the RAG-like transposon
Authors: Martin Eliza C. , Vicari Celia , Tsakou-Ngouafo Louis , Pontarotti Pierre , Petrescu Andrei J. , Schatz David G.
Published: December 2019

Background V(D)J recombination is essential for adaptive immunity in jawed vertebrates and is initiated by the RAG1-RAG2 endonuclease. The RAG1 and RAG2 genes are thought to have evolved from a RAGL (RAG-like) transposon containing convergently-oriented RAG1-like (RAG1L) and RAG2-like (RAG2L) genes. Elements resembling this presumptive evolutionary precursor have thus far only been detected convincingly in deuterostomes, leading to the model that the RAGL transposon first appeared in an early deuterostome. Results We have identified numerous RAGL transposons in the genomes of protostomes, including oysters and mussels (phylum Mollusca) and a ribbon worm (phylum Nemertea), and in the genomes of several cnidarians. Phylogenetic analyses indicate that the RAGL transposon family evolved in a vertical manner within the Bilateria clade. Many of the RAGL transposons identified in protostomes are intact elements containing convergently oriented RAG1L and RAG2L genes flanked by terminal inverted repeats (TIRs) and target site duplications with striking similarities with the corresponding elements in deuterostomes. In addition, protostome genomes contain numerous intact RAG1L-RAG2L adjacent gene pairs that lack detectable flanking TIRs. Domains and critical active site and structural amino acids needed for endonuclease and transposase activity are present and conserved in many of the predicted RAG1L and RAG2L proteins encoded in protostome genomes. Conclusions Active RAGL transposons were present in multiple protostome lineages and were transmitted vertically during protostome evolution. It appears that the RAGL transposon family was broadly active during bilaterian evolution, undergoing multiple duplication and loss/fossilization events, with the RAGL genes that persist in present day protostomes perhaps constituting both active RAGL transposons and domesticated RAGL genes. Our findings indicate that the RAGL transposon arose earlier in evolution than previously thought, either in an early bilaterian or prior to the divergence of bilaterians and non-bilaterians, and alter our understanding of the evolutionary history of this important transposon family.
Remote Closed-Loop Automatic Oxygen Control in Preterm Infants
Authors: Moradi Mohammad Reza , Kalhori Sharareh R. Niakan , Saeedi Marian Ghazi , Zarkesh Mohammad Reza , Habibelahi Abbas , Panahi Amir Hossein
Published: December 2019

Background Different automated systems have been developed to improve maintenance of target range of arterial oxygen saturation (SPO2) in premature infants with respiratory distress. This study aimed to develop a Remote Closed-Loop Automatic Oxygen Control (RCLAC) as an efficient monitoring device. Then the mean of fraction of inspired oxygen (FIO2) and SPO2 by routine manual control (RMC) and RCLAC were compared.Methods A developmental-descriptive study was carried out in an Iranian hospital (Tehran-Iran; 2015-2017). Eighteen preterm infants with gestational age 24-28 weeks entered the study. A database was prepared based on pulse oximeter parameters. A Wi-Fi module was implemented to receive data from pulse oximeter and send inputs to user's mobile. Vibrate alarm was implemented for high or low FIO2. After receiving notifications associated with increase or decrease of FIO2 levels and user's confirmation; the alterations were applied on the ventilator.Results The mean FIO2 in RMC system was significantly higher than RCLAC system (98.1± 2.67 vs. 79.5±16.03; p = 0.0001). According to the results, when the SPO2 reached close to target SPO2 range and consequently FIO2 changed (decreased or increased based on target SPO2), heart rate showed a regular beating with decrease in the numbers.Conclusion Remote Closed-Loop Automatic Oxygen Control system as a simple device could prevent preterm neonates from sustained hypo-hyperoxemic and arrhythmia episodes. Moreover by using RCLAC, there was no need for continuous monitoring that may reduce workload of NICUs medical staff. Collecting reliable data and recording information in digital forms were also other benefits.
Femoral periosteal reaction in the mid-piece of the prosthesis: a potential predictor of hip prosthetic joint infection
Authors: Zhang Zijie , Huang Zida , Li Wenbo , Fang Xinyu , Zhang Wenming
Published: December 2019

[Background] Early diagnosis of HPJI is important. Periosteal reaction has been shown to diagnose osteomyelitis and bone tumours; however, research on artificial joint infections is not clear. The purpose of this study was to analyse the diagnostic possibility of FPR on X-ray films for HPJI. [Methods] From January 2017 to June 2019, 105 patients who underwent artificial hip joint revision surgery were retrospectively included in the single joint surgery centre. Based on the description by the MSIS in 2013 and exclusion of patients with bone tumour revisions, 66 patients were reviewed and divided into the PJI group and aseptic failure (AF) group. The clinical outcome and radiographic results were examined by two experienced joint surgeons independently on hip X-ray images in all cases. Sensitivity, specificity, PPV and NPV were calculated for FPR in HPJI, and the imaging results were compared with those of serology and bacterial culture. [Results] A total of 16 patients in the PJI group were positive for FPR with appearance in the mid-piece and distal part, while 6 patients in the AF group (43.3% vs 26.1%, p = 0.04) were positive for FPR. Only 1 patient in the AF group had a mid-piece FPR, and the rest were at the distal end. Separated measurements were unidimensional (Kappa value = 0.89). The process of FPR-positive patients in the PJI group was 13 ± 26.1 months, and it was 9.83 ± 8.2 months in the AF group, and the difference was not statistically significant (p = 0.67). There was no connection between the responsible pathogens and FPR in the PJI group. The sensitivity, specificity, PPV and NPV for FPR at any section were 43.2%, 79.3%, 72.7% and 52.7%, respectively. The mid-piece FPR improved by 43.2%, 96.5%, 94.1% and 57.1%, respectively. Combined with elevated serum CRP/ ESR, specificity and PPV could reach 100%. [Conclusion] Preoperative X-ray examinations revealed that the mid-piece FPR requires a high degree of suspicion of PJI. If patients have elevated serum CRP/ESR at the same time, joint puncture and other methods should be used to obtain culture results to confirm the diagnosis.
Comparison between the Effects of Pre- and Postoperative Myocardial Injuries on 30-Day Mortality After Non-Cardiac Surgery: A Retrospective Analysis Using an Inverse Probability Weighting Adjustment
Authors: Lee Seung-Hwa , Park Jungchan , Lee Jong-Hwan , Min Jeong Jin , Hong Kwan Young , Cho Hyojin , Carriere Keumhee , Ahn Joonghyun
Published: December 2019

Background: Although both pre- and postoperative myocardial injuries are strongly associated with an increased postoperative mortality, no study has directly compared the effects of pre- and postoperative myocardial injuries on 30-day mortality after non-cardiac surgery. Therefore, we evaluated and compared the effects of pre- and postoperative myocardial injury on 30-day mortality after non-cardiac surgery.Methods: From January 2010 to December 2016, patients undergoing non-cardiac surgery were stratified into either the normal (n = 3,182), preoperative myocardial injury (n = 694), or postoperative myocardial injury (n = 756) groups. Myocardial injury was defined as a sole elevation of cardiac troponin value above the 99th percentile upper reference limit without ischemic symptom using the 4th universal definition of myocardial infarction. Patients in the preoperative myocardial injury group were further divided into the attenuated (n = 177) or persistent myocardial injury group (n = 517) according to the changes in postoperative cardiac troponin level. As the primary outcome, postoperative 30-day mortalities were compared among the groups using the weighted Cox proportional-hazards regression models with the inverse probability weighting.Results: Compared with the normal group, postoperative 30-day mortality was increased significantly both in the pre- and postoperative myocardial injury groups (1.4% vs. 10.7%; hazard ratio [HR] 3.12; 95% confidence interval [CI] 1.62-6.01; p = 0.001 and 1.4% vs. 7.4%; HR 4.49; 95% CI 2.34-8.60; p < 0.001, respectively), however, there was no difference between the pre- and postoperative myocardial injury groups (HR, 1.44; 95% CI 0.79–2.64; p = 0.45). In addition, the attenuated myocardial injury group showed a significantly lower postoperative 30-day mortality than the persistent myocardial injury group (5.6% vs. 12.4%; HR 2.23; 95% CI 1.17–4.44; p = 0.02).Conclusion: In patients undergoing non-cardiac surgery, preoperative myocardial injury also increased postoperative 30-day mortality to a similar degree of postoperative myocardial injury. In addition, attenuation of preoperative myocardial injury might decrease in 30-day mortality after non-cardiac surgery.
Interventions for prudent antibiotic use in primary healthcare: An econometric analysis
Authors: Carlsson Fredrik , Lampi Elina , Sundvall Pär-Daniel , Torres Marcela Jaime , Ulleryd Peter , Åhrén Christina , Jacobsson Gunnar
Published: December 2019

Background Rational antibiotic prescribing is crucial to combat antibiotic resistance. Optimal strategies to improve antibiotic use are not known. Strama, the Swedish strategic program against antibiotic resistance, has been successful in reducing antibiotic prescription rates. This study investigates whether two specific interventions directed toward healthcare centers, an informational visit and a self-evaluation meeting, played a role in observed reduction in rates of antibiotic prescriptions in primary healthcare.Methods The study was a retrospective, observational, empirical analysis exploiting the variation in the timing of the interventions and considering past prescriptions through use of estimations from dynamic panel data models. Primary healthcare data from 2011 to 2014 were examined. Data were from public and private primary healthcare centers in western Sweden. The key variables were prescription of antibiotics and indicator variables for the two interventions.Results The first intervention, an educational information intervention, decreased the number of prescriptions among public healthcare centers, but this effect was only temporary. We found no proof that the second intervention, a self-evaluation meeting at the healthcare center, had an impact on the reduction of prescriptions.Conclusions Single educational interventions aimed at influencing rates of antibiotic prescriptions have limited impact. A multifaceted approach is needed in efforts to reduce the use of antibiotics in primary health care.
WITHDRAWN: The Male Reproductive Structure and Spermatogenesis of Trypophloeus Klimeschi Eggers (Coleoptera: Curculionidae: Scolytinae)
Authors: Gao Jing , Gao Guanqun , Dai Lulu , Wang Jiaxing , Chen Hui
Published: December 2019

Background Trypophloeus Klimeschi Eggers (Coleoptera: Curculionidae: Scolytinae) is one of the most destructive pests of Populus alba var. pyramidalis (Bunge), resulting in significant losses in economic, ecological and social benefits in China’s northwest shelter forest. But research of reproductive system, spermiogenesis and spermatozoon ultrastructure of T. klimeschi that is basis of phylogeny, reproductive biology and controlling is still black. Results The male reproductive organ of T. klimeschi is composed of testis, seminal vesicle, strand shaped accessory gland containing long branch of strand shaped accessory gland and short branch of strand shaped accessory gland, curly accessory gland, vas deferens and a common ejaculatory duct. The number of sperm per cyst is 350~512. Its spermatozoon is slender, measuring about 75 μm in length and 0.5 μm in wide and composed of a 3-layred acrosomal complex, a nucleus with two different states of aggregation, two mitochondrial derivatives with dark crystal, a 9+9+2 axoneme that run more or less parallel to mitochondrial derivatives, two crystalline accessory bodies with a big compact “puff”-like expansion. Especially in the seminal vesicle, its long flagella folded into several turns and the whole sperm is wrapped in a film.Conclusion The general morphology of male reproductive tract, the spermatogenesis and the spermatozoa of T. klimeschi are, for the most part, similar to the majority of the Curculionidae. However, some distinct differences were found: the low electron-dense band in the cytoplasm of spermatocytes; two different aggregation states of spermatozoon nucleus; especially the stored way of T. klimeschi spermatozoa.
The circulating level of Non-coding RNA for breast cancer diagnosis
Authors: wang miao , gu yao , zhang jie , jia zhaojun , wu huijian
Published: December 2019

Background: Lots of non-coding RNAs expression affected breast cancer progression. However, there were no systemic analysis of non-coding RNAs for breast cancer diagnosis in circulatory system. Herein, we aimed to collect all the evidence to test the potential role of non-coding RNAs as novel biomarker in human breast cancers. Methods: A comprehensive search strategy was used to search relevant literatures in the Web of Science, PubMed, and Embase databases from 2012 to November 2019. The correlation between non-coding RNAs in serum, plasma or blood expression and the diagnostic accuracy of BC markers were analyzed. The methodological quality of each study was assessed using the QUADAS-2. Statistical analysis was used the STATA (version 12.0), Meta-Disc1.4 and Review Manager (version 5.3) software. Results: The present meta-analysis the non-coding RNAs expression data of BC patients and healthy specimens’ bloodfrom 2392 patients in 24 publications (32 studies). The pooled sensitivity, specificity, and AUC values were 0.82, 0.83, and 0.89, respectively. Subgroup analyses showed that the expression of non-coding RNA (miRNA, circRNA, andlncRNA) in circulating (including blood, plasma, and serum) of BC was more prone to be detected in TNM stage and subtype of BC group, with a high value of the sensitivity and AUC. Conclusions: The circulating (including blood, plasma, and serum) level of miRNAs, circRNAs, and lncRNAs for breast cancer diagnosis may be effective, particularly in TNM stage, subtype of BC (ER/PgR, PR or HER2/c-erbB-2) breast cancer. Further prospective studies on the diagnostic value of non-coding RNAs from breast cancer are needed in the future.
STUDY OF FATTY ACID COMPOSITION OF MILK FOR CHEESE PRODUCTION
Authors: Topnikova E. V. , Mordvinova V. A. , Sviridenko G. M. , Danilova E. S.
Published: December 2019

The article shows that the studied samples of raw milk in terms of composition (mass fraction of fat, protein, lactose and milk solids-not-fat) met the criteria of suitability for cheese, and its physic-chemical properties (titratable acidity, density, freezing point) were within acceptable limits. Moreover, rennet sample corresponded to the first and second classes. It was proved that the number of spores of lactating fermenting microorganisms met the requirements for milk for the production of any kind of cheese. It was established that the fatty acid composition of raw cow’s milk used to produce cheeses at various enterprises varied significantly. The data indicate the variability of the content of all groups of fatty acids — low molecular weight, saturated, monounsaturated and polyunsaturated. As a result of gas chromatography studies using the chromatographic complex «Chromos GX-1000» with a flame ionization detector and a CP 88 quartz capillary column — Sil 88 for FAME100 m × 0.25 mm × 0.2 µm, it was found that the largest absolute fluctuations were for saturated (± 7.03 % of the average value) and monounsaturated fatty acids (± 3.77 % of the average value). Absolute fluctuations in the group of low molecular weight fatty acids amounted to ± 2.62 %, and in the group of polyunsaturated — ± 1.02 % of the average value. The calculation of the relative deviation showed that the most varied groups were the ones of low molecular weight fatty acids (± 28.40 rel.%) and polyunsaturated fatty acids (± 25.11 rel.%). At the same time, a relatively high content of certain fatty acids: myristoleic, palmitic, palmitoleic and low levels of stearic and oleic fatty acids, was revealed in individual milk samples.
Development of cluster business of the Euro-Arctic economic zone (on the example of the Murmansk region)
Authors: Khatsenko E. S. , Chudinov K. A. , Lashin D. A.
Published: December 2019

The article is devoted to the problems and prospects of cluster entrepreneurship development in the Euro-Arctic economic zone. Consider measures to support regional producers, sets out measures to support regional entrepreneurship. Special attention is paid to the development of the marketing concept of the enterprise cluster. A tool for the development of cluster entrepreneurship through the introduction of umbrella branding system is proposed
Peculiarities of pension systems of the BRICS countries
Authors: Aleksahina V. G. , Ignatova O. V.
Published: December 2019

The article deals with features of pension provision in the BRICS countries.
Regional and industry characteristics of trade and economic cooperation of the EEU countries
Authors: Taranov P. M. , Gerasimov A. N.
Published: December 2019

In the paper, trends and patterns of development of trade and economic cooperation of the EEU countries are analyzed. The authors, based on the economic-static analysis of international trade, study the features of the transformation of the commodity and regional structure of trade. Conclusions are drawn about the reasons for the existing features and trends in the development of intraregional economic cooperation.
Forecast of development of vegetable growing industry in the North-West of Russia
Authors: Kiseleva Е. А.
Published: December 2019

The article discusses the development of the vegetable industry in the North-West of Russia. The analysis reveals the main trends in the production of vegetables, the assessment of their provision to the population of the region. The system of indicators for innovative forecasting of development of branch on the medium-term and long-term prospect allowing to reach further indicators of food safety is offered. The main directions of investment for the development of the industry are described. The forecast of vegetable production in the North-West Federal district is based on the introduction of innovations until 2022.
Mechanism of economic agglomeration of territories: the contribution of labor and efficiency wages
Authors: Borodin V. A. , Machin K. A.
Published: December 2019

The article describes the economic mechanism of analytical modeling of spatial heterogeneity based on economic agglomeration. Special attention is paid to labor market factors, such as effective wages, workers' efforts and labor migration. The migration mobility of labor is generated by the condition of maximizing the utility of the employee, and the effective wage in the centers of agglomerations acts as a kind of proportional measure of this utility. Higher wage rates in agglomerations attract better quality workers from nearby territories and contribute to increasing the efforts of workers in their current workplaces. Thus, effective wages create a synergetic production agglomeration effect in the development of the region.
Methodological approaches to labor market research the Vologda region
Authors: Krylova N. P. , Levashov E. N.
Published: December 2019

The article considers methodological approaches to the study of the regional labor market. The interpretation of the methodological approach concept is given, the description of existing approaches to the labor market research is given too. The authors consider the indicators of the labor market in the Vologda region in the course of several years, carry out a forecast of the needs of the region's labor resources, identify the most demanded areas of training in secondary vocational and higher education, and analyze the employment and wages of graduates of Vologda region universities.
Innovation and technological progress as a catalyst development effectiveness of industrial enterprises
Authors: Meshcheryakova Y. S.
Published: December 2019

Innovative aspects are the final result of the introduction of elements of scientific-technical progress that is appropriate in a changing process of industrial enterprise management and improve the efficiency of its development.
Improvement of methods of cadastral valuation of real estate on the basis of urban development value of the territory. Part II
Authors: Osennyaya A. V. , Khakhuk B. A. , Kolomytseva А. А.
Published: December 2019

In the article the authors present step - by-step calculation of cadastral value of real estate objects on the example of six valuation zones of Krasnodar municipal district, located in different parts of the city, according to the proposed methodology based on the urban value of land. A list of objects of evaluation, as well as the types of permitted use. The calculation of the integral index and the cadastral value of the considered objects are determined by the proposed method.
Methods of assessment the resource potential in agriculture
Authors: Osmolovskaya S. P. , Kotakova N. A.
Published: December 2019

In the research, based on the study of the use of resource potential in agriculture on the example of the Vologda region, has revealed the features of its development, taking into account industry specifics. The authors have proposed a method of complex assessment the resource potential at an enterprise using the coefficient of the force of entrepreneurial influence.
Stimulating the development of innovative entrepreneurship in the context of globalization
Authors: Pavlenko I. G. , Osmanova E. U. , Linshi Xu , Ovcharenko N. P.
Published: December 2019

The article considers the role and influence of innovation activity in the development of the real sector of the state economy. The directions of the state policy in the sphere of regulation of youth innovative entrepreneurship on the example of the Republic of Crimea are generalized and structured. The structure of employment and unemployment in the Russian Federation and the Republic of Crimea are analyzed.
Impact of social innovations оn regional development: conceptual framework
Authors: Soloveva T. S.
Published: December 2019

The article deals with the role and directions of the social innovations’ impact on regional development. In retrospect, the author considers the essence of social innovations. The functional features of social innovations have been highlighted. A conceptual model of the social innovations’ impact on regional development has been proposed. The results obtained made it possible to formulate the main vectors of social innovation development as a factor of social progress and economic growth of a region.
Creating an expert system for assessing the economic efficiency of investments in information security
Authors: Salmanova I. P. , Kuznetsova O. I. , Kruchinina S. A. , Bulat A. S.
Published: December 2019

The need for tools substantiate and assess the effectiveness of investment in information security - one of the most important problems of our time. The possible direction of the solution of the identified problem is the construction of an expert system that will improve the efficiency and operativeness of the decisions made. The basis for building such a system is most appropriate to choose the methodology of ROSI - the estimation of the return of investments in information security, which in particular allows you to determine the payback period of the investment project. The developed program model of expert system allows to reasonably estimated effectiveness of the cost for information security.
Ecological tax in the system of environmental safety
Authors: Boboshko N. M.
Published: December 2019

The article considers the system of environmental taxation, reveals the main elements of environmental tax. The analysis of the mechanism of the introduced tax is carried out, its environmental function is estimated. The estimation of the progressive system of taxation environmental tax of business entities that pollute the environment, and its stimulating effect, aimed at reducing such pollution.
Dynamics and statics of the development of competition in the labour sphere on the Siberian Federal District
Authors: Kravtsevich S. V. , Tulokhonov O. S.
Published: December 2019

This article examines the cyclical development of competitive processes and formation of competitive Wednesday segmentation in the labour sphere on the example of the Siberian Federal District. Analysis of dynamics and statics of statistical indicators of competition at work. Competition in the field of work on Siberian Federal District has a tendency not to harmonious development and varies in its course and manifestation in different time periods in the post-Soviet space and in the constituent entities of the Russian Federation. Development of competitive processes in employment is characterized by its cycles, and Wednesday the formation of a competitive labour is inherent in the segmentation of the Siberian Federal District.
Resource support for the development of entrepreneurship in the recreational sector of the Greater Yalta region
Authors: Pavlenko I. G. , Bukreev I. A.
Published: December 2019

The article is devoted to the future development of entrepreneurship in the recreational sector of the Greater Yalta region, namely, the assessment of the recreational potential as its resource provision. The assessment of the recreational potential of the Big Yalta region in the structure of the recreational potential of the Republic of Crimea has been carried out. In assessing the potential, resources of a natural, socio-cultural and material-technical nature were considered. According to this estimate, the recreational potential of Big Yalta was just over 20% of the potential of the Crimea, with an occupied area of 1.1% of the total area. Territorial concentration is 18.4 times higher than in the region.
Problem areas of customs and logistics activities
Authors: Suleimanov Z. E. , Glekova V. V.
Published: December 2019

Russia's dynamic participation in international trade rapidly brings to the fore the ability of all participants in the processes of foreign trade to effective relations at all levels. The article identifies the main blocks of problems in improving the management of cross-border business processes. The conditions of efficiency of customs and logistics activities are formalized.
Information and communication technologies of management in housing and communal services of the Bryansk region: the factors constraining functioning
Authors: Tarasova N. V. , Protchenko M. V.
Published: December 2019

Housing and communal services – a complex system which in the changing social and economic conditions is not capable to adapt to them flexibly. Therefore use of new administrative mechanisms, including with application of information and communication technologies is necessary. The conditions promoting their application and the factors constraining effective functioning are analyzed an assessment is given to the prospects of development of housing and communal services with application of information and communication technologies for real improvement of quality of life of the population, considering inquiries. High-quality integration of management decisions with application of information and communication technologies, will allow the region to achieve sustainable development.
Developing a ranking of regions by degree climate security
Authors: Vasiltsov V. S. , Yashalova N. N.
Published: December 2019

A study of the essence of the concept “climate security” is conducted and key directions of its impact on the economic system are determined. The increasing influence of anthropogenic climate change on socio-economic processes in the regions of Russia, in the country and the world as a whole in the development and implementation of the country's climate policy is analyzed. The article substantiates the need to develop the basics of climate security at the regional level, where the regions will be ranked by the level of climate threat.
Complex assessment of ekologooriyentirovanny capacity of the region as factor of development of innovative economy
Authors: Chistyakova T. Yu.
Published: December 2019

One of the main objectives of ekologo-economic researches is development and realization of strategy of sustainable development of the Russian Federation and its territorial, industrial complexes which assumes strengthening of economy, maintaining favorable quality of the environment and balance of social and economic, ecological and social interests at all levels of public administration. In these conditions there is obvious a need of development and use of nonconventional approaches to the solution of ekologo-economic problems, search of new reserves of development of the country.
Space Insurance: Basic Concepts, Types, Risks, Objects, Features
Authors: Babina N. V. , Bashirova S. V. , Samarov E.
Published: December 2019

The article is devoted to the Space Insurance, which is a separate complex direction in insurance. It includes the consideration of the basis of space insurance, decomposition of its main components to the level of objects and risks and their groups for each of types of space insurance, design and description of the most widespread variants of the organization of insurance protection for the space projects.
Digital technologies and their influence on the innovative development of the regional industrial complex
Authors: Veselovsky M. Y. , Pogodina T. V.
Published: December 2019

The article examines the trends of innovative development of industrial production, including the active transition to Industry 4.0. Digital technologies used by industrial companies in the world, Russia and its individual regions are identified and analyzed. The use by a small number of Russian companies of predominantly digital second-tier technologies was noted. A proposal has been formulated on the need to form a digitalization strategy for production activities on the basis of technological platforms in cooperation with industrial clusters in the field of IT technologies.
Efficiency of process management at enterprises of rocket-space industry
Authors: Gumanyuk E. S.
Published: December 2019

The article indicates the key tasks and issues of strategic management of the enterprise of the rocket and space industry (RSI). The analysis of existing algorithms is carried out, and also the optimal way of modeling and substantiation of management decisions in the field of innovative transformations of RSI enterprises is presented. The authors presented and compared an economic-mathematical models for evaluating the effectiveness of the use of process management. Analyzed the possibility of developing existing approaches to ensure the effectiveness of the process approach to the management of the enterprise.
Waste recycling as direction of increase in efficiency of use of resources
Authors: Dzhamaldinova M. D. , Kurdukova N. O.
Published: December 2019

The article investigates the approaches of waste management, studied and analyzed the ways of using waste for further production of goods. Special attention is paid to the study of the main tasks, principles of economic regulation in the field of waste management in the Russian Federation. The directions of ensuring environmentally safe waste management are presented; alternative models of development of ecological strategy of the enterprise are formed.
Areas of improvement of project management
Authors: Kelesh Y. V. , Bessonova E. A.
Published: December 2019

The article substantiates the relevance of the study of the project approach in the activities of regional authorities, describes the projects implemented in the Kursk region, conducted a SWOT analysis of the implementation and implementation of project management in the region, considered the elements of the institutional environment (the legal framework of PU, objects and subjects of PU, the process of implementation of PU), the formation of which is necessary to build an effective system of management of socio-economic development of territorial education.
The innovation transformation of telecom industry
Authors: Lomаtenkov D. A. , Gnezdova J. V.
Published: December 2019

In article is considered investments into development of telecom industry on the basis of digital technologies, contrary to popular belief which optional should be long-term. At the same time adaptation of organizational model and development of the corporate culture oriented to innovations – one of the most important conditions of success. At the same time the Russian telecommunication sector is at an early stage of development in all directions of digital conversions.
Land tax in the tax system of the Russian Federation
Authors: Abakarova R. Sh.
Published: December 2019

Land pricing is an effective tool for land management in the modern world.Measures to improve the fiscal component of the land tax ensure the independence of local budgets. The source of local budget replenishment is local taxes.In the current tax system, the amount of calculated tax is transferred to local budgets. The main problem that the leaders of the Defense Ministry are facing today is the lack of funds for development and for current needs. The question of meeting the financial needs of municipalities is a question of the revenue base of local budgets.The existing problems associated with the collection of land tax are diverse.Unlike market valuation of land, cadastral valuation is performed by mass valuation methods, using statistical processing of indicators. There is a need to take into account the individual characteristics of land.
Structural shifts in household consumption of the Chuvash Republic: causes and effects
Authors: Vasileva O. G. , Litvinova O. V. , Abrosimova M. S.
Published: December 2019

The analysis of structural changes in the consumption of households of the Chuvash Republic over the past two decades has been carried out, highlighting cause-effect relationships. Special attention is paid to the crisis of income and consumption in recent years, which in turn has caused a strong contraction in domestic demand.
Initiative budgeting: experience of Russian regions
Authors: Lysova N. A.
Published: December 2019

Experience of participatory budgeting in municipalities of Russian regions is reviewed in the paper. Forms of participation of the population in decision-making, as well as in the selection, realization and co-financing of public projects have been investigated. The analysis of the practices made it possible to identify the features and prospects of the Russian model of initiative budgeting.
Enlargement of rural settlements as method of reduction of charges on management
Authors: Rerikh L. M.
Published: December 2019

Investigation of numerous rural settlements with the small number of population are non-productive charges of budgets on a management. The modern terms of development of communication and communications means allow to administrations of village soviets to carry out a management in more large rural settlements, that will allow more rationally to use budgetary facilities. Analysis of structure and dynamics of budgetary charges on a management 45 rural settlements of three municipal districts of the Novosibirsk area allowed to the author to offer certain variants on enlargement of rural settlements with the purpose of increase of efficiency of the use of budgetary facilities.