bluuebunny/crossref_metadata_2025 huggingface dataset:
When Women Study Men: Gendered Implications for Qualitative Research
Authors: Lefkowich Maya
Published: August 2019

As a White cis female researcher, I am often asked about my capacity to conduct meaningful, credible, and safe research with men. Questions often center on my experiences in men’s spaces, ability to understand or represent men’s experiences, and safety protocols to mitigate against looming threats of male-perpetrated violence. I am curious about how my gender continues to be a point of contention in my role as a qualitative researcher. In this meta-analysis and commentary article, I explore my experiences in relation to other female researchers who study men and who have published articles reflecting on gender norms in research practice. With examples taken from the contexts of fieldwork, qualitative interviews, and presentation of findings, this article illustrates the nuanced and often invisible power and gender dynamics that inform how methodological decisions are made, what is found or synthesized from qualitative data, and how problematic social norms are reinforced. I argue that, within the context of research about men and masculinities, researchers must be responsible for reflecting on and confronting gender norms as a part of their intersectional experiences of privilege and oppression. Specifically, researchers can use reflexive practice and field journaling to better understand how gender norms and uneven power dynamics are introduced to, co-constructed within, and generated from qualitative studies. These reflections and concerted efforts to confront broader social injustices imbedded in research practices are necessary for researchers to produce sound data and promote reciprocal research benefits. Without such efforts, researchers may reinforce the same structures of power and stereotypical gender norms that they aim to disrupt in their scholarship.
Computer vision and pursuit–evasion game theoretical controls for ground robots
Authors: Shen Dan , Ling Haibin , Pham Khanh , Blasch Erik , Chen Genshe
Published: August 2019

A hardware-in-loop control framework with robot dynamic models, pursuit–evasion game models, sensor and information solutions, and entity tracking algorithms is designed and developed to demonstrate discrete-time robotic pursuit–evasion games for real-world conditions. A parameter estimator is implemented to learn the unknown parameters in the robot dynamics. For visual tracking and fusion, several markers are designed and selected with the best balance of robot tracking accuracy and robustness. The target robots are detected after background modeling, and the robot poses are estimated from the local gradient patterns. Based on the robot dynamic model, a two-player discrete-time game model with limited action space and limited look-ahead horizons is created. The robot controls are based on the game-theoretic (mixed) Nash solutions. Supportive results are obtained from the robot control framework to enable future research of the robot applications in sensor fusion, target tracking and detection, and decision making.
Digital Diabetes Congress 2019
Authors: Han Julia , King Fraya , Klonoff David , Drincic Andjela , Crosby Keesha Perkins , Robinson Thomas , Gabbay Robert A. , Oley Leslie , Ahn David , Evans Bill , Salber Patricia , Cruz Marisa , Ginsberg Barry , Adi Saleh , Armstrong David , Kerr David
Published: August 2019

New applications of digital health software and sensors for diabetes are rapidly becoming available. The link between healthcare, wearable or carryable devices, and the use of smartphones is increasingly being used by patients for timely information and by healthcare professionals to deliver information and personalized advice and to encourage healthy behavior. To assemble stakeholders from academia, industry, and government, Diabetes Technology Society and Sansum Diabetes Research Institute hosted the 3rd Annual Digital Diabetes Congress on May 14-15, 2019 in San Francisco. Physicians, entrepreneurs, attorneys, psychologists, and other leaders in the diabetes technology field came together to discuss current and future trends and applications of digital tools in diabetes. The meeting focused on eight topics: 1) User Interface/User Experience (UI/UX) for Digital Health, 2) clinical aspects, 3) marketing, 4) investment, 5) regulation, 6) who owns the data, 7) engagement, and 8) the future of digital health. This meeting report contains summaries of the meeting’s eight plenary sessions and eight panel discussions, which were all focused on an important aspect of the development, use, and regulation of diabetes digital tools.
Healthy Weight for Life programme: Evaluating the practice and effectiveness of a weight loss maintenance programme in the private health insurance setting
Authors: McGill Bronwyn , O’Hara Blythe J , Grunseit Anne C , Bauman Adrian , Lawler Luke , Phongsavan Philayrath
Published: August 2019

Background:

Australian private health insurers are increasingly involved in the delivery of chronic disease management programmes to their members, recognising the importance of decreasing and managing lifestyle risk factors and the impact such factors have on health service utilisation. One such secondary prevention programme is the Healthy Weight for Life programme, an intensive weight loss and lifestyle modification programme that has been designed for overweight and obese private health insurance members in Australia. Together with the insurer, the Healthy Weight for Life service provider developed and implemented a long-term maintenance programme that supports participants who complete the Healthy Weight for Life programme to maintain the weight loss they achieved during the programme. Various studies have shown that evidence-based weight management programmes can be effective; however, the results may vary in different contexts.

Objective:

This article presents the evaluation rationale and framework designed to assess the process and impact of the long-term maintenance programme on weight loss maintenance, other health-related benefits and participants’ experience with the programme.

Methods:

The evaluation will comprise a number of inter-related sub-studies balancing evaluation of programme effectiveness and implementation. The maintenance programme presented a unique opportunity for researchers to partner with private health insurance and a service provider to assess a real-world programme in the under-researched area of weight loss maintenance in this setting and emphasises the importance of evaluating such programmes given the potential the private health insurance context has in the future delivery of health care.
Striving for a biopsychosocial approach: A secondary analysis of mutual components during healthcare encounters between women with endometriosis and physicians
Authors: Berterö Carina , Alehagen Siw , Grundström Hanna
Published: August 2019

Objective:

The objective of this study was to identify and describe mutual components during healthcare encounters between women with endometriosis and physicians.

Methods:

Secondary analysis of data was obtained from two original face-to-face interview studies, one with nine women with endometriosis and one including 16 physicians. Data in this secondary analysis were analysed using thematic analysis.

Results:

Three themes were identified. (1) Continuity as a foundation for a biopsychosocial approach. The women and the physicians described the importance of continuity and both parties strived for a biopsychosocial approach whereby the female body was not treated as biomedical defect object, but as a part of the unity that constitutes a human being. (2) Listening sensitively. Women and physicians believed that listening sensitively involved more than just hearing the actual words – it required thoughtfulness, reflection and responsiveness. (3) Timing of diagnosis. The physicians tried to protect the women from worrying by treating the painful menstruations without mentioning endometriosis. However, the women regarded not mentioning endometriosis as a lack of competence on the part of the physicians.

Conclusion:

This study provides new insights into the need for further support in the provision of psychosocial care for women with endometriosis, in the striving towards a biopsychosocial approach.
Filamin A: key actor in platelet biology
Authors: Rosa Jean-Philippe , Raslova Hana , Bryckaert Marijke
Published: August 2019

Filamins are scaffold proteins for signaling proteins and adhesion molecules, and mutations in filamin A (FLNa) cause a wide range of defects in the brain, cardiovascular system, gastrointestinal tract, and skeleton, as well as in megakaryocytes. Rosa and colleagues review the important role of FLNa in platelet development and its critical importance to proplatelet production by megakaryocytes.
Oral 5-azacytidine and romidepsin exhibit marked activity in patients with PTCL: a multicenter phase 1 study
Authors: O’Connor Owen A. , Falchi Lorenzo , Lue Jennifer K. , Marchi Enrica , Kinahan Cristina , Sawas Ahmed , Deng Changchun , Montanari Francesca , Amengual Jennifer E. , Kim Hye A. , Rada Aishling M. , Khan Karen , Jacob Alice T. , Malanga Michelle , Francescone Mark M. , Nandakumar Renu , Soderquist Craig R. , Park David C. , Bhagat Govind , Cheng Bin , Risueño Alberto , Menezes Daniel , Shustov Andrei R. , Sokol Lubomir , Scotto Luigi
Published: August 2019

The authors report a phase 1 study of romidepsin combined with oral 5-azacytidine in patients with relapsed/refractory lymphomas, including complete remissions in 3 patients with angioimmunoblastic T-cell lymphoma.
Dose-escalated interleukin-2 therapy for refractory chronic graft-versus-host disease in adults and children
Authors: Whangbo Jennifer S. , Kim Haesook T. , Mirkovic Nikola , Leonard Lauren , Poryanda Samuel , Silverstein Sophie , Kim Soomin , Reynolds Carol G. , Rai Sharmila C. , Verrill Kelly , Lee Michelle A. , Margossian Steven , Duncan Christine , Lehmann Leslie , Huang Jennifer , Nikiforow Sarah , Alyea Edwin P. , Armand Philippe , Cutler Corey S. , Ho Vincent T. , Blazar Bruce R. , Antin Joseph H. , Soiffer Robert J. , Ritz Jerome , Koreth John
Published: August 2019

Low-dose interleukin-2 (IL-2) therapy for chronic graft-versus-host disease (cGVHD) generates a rapid rise in plasma IL-2 levels and CD4+CD25+CD127−Foxp3+ regulatory T-cell (CD4Treg) proliferation, but both decrease over time despite continued daily administration. To test whether IL-2 dose escalation at the time of anticipated falls in plasma levels could circumvent tachyphylaxis and enhance CD4Treg expansion, we conducted a phase 1 trial in 10 adult and 11 pediatric patients with steroid-refractory cGVHD (www.clinicaltrials.gov: NCT02318082). Daily IL-2 was initiated in children and adults (0.33 × 106 and 0.67 × 106 IU/m2 per day, respectively). Dose escalations were scheduled at weeks 2 and 4 to a maximum dose of 1 × 106 IU/m2 per day in children and 2 × 106 IU/m2 per day in adults. Patients continued at their maximum tolerated dose (MTD) until week 8. Children tolerated IL-2 dose escalation with partial responses (PRs) in 9 of 11 patients (82%) at multiple cGVHD sites, including lung. Patient-reported outcome scores for skin and lung improved significantly in pediatric patients. In contrast, 5 of 10 adults required dose reduction, and only 2 of 7 evaluable patients (29%) had PRs at week 8. CD4Tregs and natural killer cells expanded in both cohorts without significant changes in conventional CD4+ T cells (Tcons) or CD8+ T cells. Children achieved a higher median CD4Treg/Tcon ratio at week 8 (0.4 vs 0.18, P = .02) despite lower IL-2 doses. We show for the first time that low-dose IL-2 is safe and effective in children with advanced cGVHD. In adults, escalation above the previously defined MTD did not improve CD4Treg expansion or clinical response.
A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1
Authors: Xia Xin , Li Xixi , Li Fanying , Wu Xujia , Zhang Maolei , Zhou Huangkai , Huang Nunu , Yang Xuesong , Xiao Feizhe , Liu Dawei , Yang Lixuan , Zhang Nu
Published: August 2019

Background

The RTK/PI3K/AKT pathway plays key roles in the development and progression of many cancers, including GBM. As a regulatory molecule and a potential drug target, the oncogenic role of AKT has been substantially studied. Three isoforms of AKT have been identified, including AKT1, AKT2 and AKT3, but their individual functions in GBM remain controversial. Moreover, it is not known if there are more AKT alternative splicing variants.

Methods

High-throughput RNA sequencing and quantitative reverse transcription-PCR were used to identify the differentially expressed circRNAs in GBM samples and in paired normal tissues. High throughput RNA sequencing was used to identify circ-AKT3 regulated signaling pathways. Mass spectrometry, western blotting and immunofluorescence staining analyses were used to validate AKT3-174aa expression. The tumor suppressive role of AKT3-174aa was validated in vitro and in vivo. The competing interaction between AKT3-174aa and p-PDK1 was investigated by mass spectrometry and immunoprecipitation analyses.

Results

Circ-AKT3 is a previously uncharacterized AKT transcript variant. Circ-AKT3 is expressed at low levels in GBM tissues compared with the expression in paired adjacent normal brain tissues. Circ-AKT3 encodes a 174 amino acid (aa) novel protein, which we named AKT3-174aa, by utilizing overlapping start-stop codons. AKT3-174aa overexpression decreased the cell proliferation, radiation resistance and in vivo tumorigenicity of GBM cells, while the knockdown of circ-AKT3 enhanced the malignant phenotypes of astrocytoma cells. AKT3-174aa competitively interacts with phosphorylated PDK1, reduces AKT-thr308 phosphorylation, and plays a negative regulatory role in modulating the PI3K/AKT signal intensity.

Conclusions

Our data indicate that the impaired circRNA expression of the AKT3 gene contributes to GBM tumorigenesis, and our data corroborate the hypothesis that restoring AKT3-174aa while inhibiting activated AKT may provide more benefits for certain GBM patients.
Benefits and Challenges of Instructing Introductory Biology Course-Based Undergraduate Research Experiences (CUREs) as Perceived by Graduate Teaching Assistants
Authors: Heim Ashley B. , Holt Emily A.
Published: August 2019

Graduate teaching assistants (GTAs) are often the primary instructors for undergraduate biology laboratories and serve as research mentors in course-based undergraduate research experiences (CUREs). While several studies have explored undergraduate perceptions of CUREs, no previous study has qualitatively described GTAs’ perceptions about teaching CUREs, despite the essential instructional role GTAs play. The purpose of this phenomenological study was to describe and ascribe meaning to the perceptions that GTAs have regarding benefits and challenges with instructional experiences in introductory biology CUREs. We conducted semistructured interviews with 11 GTAs instructing an introductory biology CURE at a 4-year public university. We found that, while GTAs perceived professional benefits such as experience in research mentoring and postsecondary teaching, they also described challenges, including the time required to instruct a CURE, motivating students to take ownership, and a lack of expertise in mentoring undergraduates about a copepod-based CURE. Feelings of inadequacy in serving as a research mentor and high levels of critical thinking were also cited as perceived issues. We recommend that the greater responsibility and increased time commitment perceived by GTAs in the current study warrants reconsideration by lab coordinators and administrators as to what content and practices should be included in pedagogical training specifically designed for CURE GTAs and how departmental and institutional policies may need to be adapted to better implement CUREs.
Macroscopic mechanical properties of porous rock with one saturating fluid
Authors: Deng Wubing , Morozov Igor B.
Published: August 2019

Effective frequency-dependent moduli and [Formula: see text]-factors are broadly used for characterizing the behavior of earth media in laboratory and field seismic observations. However, such properties are wavemode- and experiment-dependent and are often incomplete and/or inaccurate for modeling realistic situations. For example, viscoelastic moduli for porous fluid-saturated rock are usually derived for primary waves, but they may not apply to cases in which secondary waves are important, such as reflections in finely layered poroelastic media or quasistatic pore-fluid flows in laboratory experiments. To obtain a model applicable to all cases, equations of mechanics should be used, and mechanical properties of the material must be identified. To reveal and measure such properties for fluid-saturated porous rock, we have developed a Biot-consistent model based on Lagrangian continuum mechanics. The model is “minimal,” purely macroscopic, and independent of the macrostructure or patterns of pore-fluid flows; thus, it could represent many existing wave-induced fluid-flow (WIFF) as well as non-WIFF models. Due to its mechanical definition, the model should be applicable to all rock-physics experiments (linear creep, pore flow, low-frequency, resonant, or ultrasonic), any waves in the field (primary, secondary, standing, surface, etc.) under arbitrary boundary conditions, and also finite-difference and finite-element numerical modeling. When based on this model, numerical simulations require no integral equations, fractional derivatives, memory variables, or additional kinetic equations. We further use the model to invert for detailed elastic and viscous properties of fluid-saturated Berea and Fontainebleau sandstones from recently published low-frequency laboratory experiments. All rock properties inferred in the model are time- and frequency-independent, comparable to other physical observations, and the model closely predicts the data. The model can be approximately pore-fluid independent, which allows performing rigorous fluid substitution with viscous pore fluids. As an illustration, P-wave velocity dispersion and attenuation in water-, oil-, and gas-saturated sandstone are simulated.
2D lateral imaging inversion for directional electromagnetic logging-while-drilling measurements
Authors: Thiel Michael , Omeragic Dzevat
Published: August 2019

Deep-directional electromagnetic (EM) logging-while-drilling technology can map reservoir boundaries and fluid contacts for strategic geosteering, reservoir navigation, and more recently, for reservoir characterization. The inversion-based resistivity mapping is used to make real-time geosteering decisions and to refine and update the reservoir model during and after drilling. Traditional 1D and 2D inversion approaches ignore the lateral changes of the reservoir, which are contained in the azimuthally sensitive measurements and only provide a longitudinal 2D representation of the 3D reservoir structure around the well. A new 2D lateral imaging inversion uses the full azimuthal sensitivity of the measurements to map the vertical and lateral resistivity heterogeneities around the wellbore. A 2.5D EM solver is run in a Gauss-Newton optimization to reconstruct the measurements in complex scenarios and determine the 2D anisotropic resistivity distribution in an imaging plane along with the orientation of the formation invariant direction with respect to the wellbore. Continuous 2D imaging along the well path generates a 3D reservoir resistivity map in the proximity of the wellbore.
Scaling Nature
Authors: Robertson Kellie
Published: August 2019

Late medieval writers were enamored with metaphors of scale for imagining mankind in relation to the rest of the created world. This article takes the minor mundus — the idea of the human as a “lesser world” patterned after the greater, cosmic one — as a point of departure for exploring medieval debates about what it meant to be an embodied human that stood simultaneously apart from and yet within the natural world. It argues that microcosmic thinking was particularly prominent in the tradition of the Roman de la Rose, because it allowed writers to enter into a long-standing conversation about how the physical environment potentially influenced the human will. A scalar logic of nature was embraced by some of these popular writers and rebuffed by others, depending on their view of how the soul was situated with respect to the material body. Revisiting these ubiquitous microcosmic figures gives us insight into sometimes opaque medieval intellectual practice even as it demonstrates how the history of rhetoric can contribute to a broader history of materialism.
Physical Performance Measures Correlate with Head Impact Exposure in Youth Football
Authors: KELLEY MIREILLE E. , JONES DEREK A. , ESPELAND MARK A. , ROSENBERG MEAGAN L. , MILES CHRISTOPHER M. , WHITLOW CHRISTOPHER T. , MALDJIAN JOSEPH A. , STITZEL JOEL D. , URBAN JILLIAN E.
Published: August 2019

Purpose

Head impact exposure (HIE) (i.e., magnitude and frequency of impacts) can vary considerably among individuals within a single football team. To better understand individual-specific factors that may explain variation in head impact biomechanics, this study aimed to evaluate the relationship between physical performance measures and HIE metrics in youth football players.

Methods

Head impact data were collected from youth football players using the Head Impact Telemetry System. Head impact exposure was quantified in terms of impact frequency, linear and rotational head acceleration, and risk-weighted cumulative exposure metrics (RWELinear, RWERotational, and RWECP). Study participants completed four physical performance tests: vertical jump, shuttle run, three-cone, and 40-yard sprint. The relationships between performance measures, and HIE metrics were evaluated using linear regression analyses.

Results

A total of 51 youth football athletes (ages, 9–13 yr) completed performance testing and received combined 13,770 head impacts measured with the Head Impact Telemetry System for a full season. All performance measures were significantly correlated with total number of impacts in a season, RWELinear-Season, and all RWE-Game metrics. The strongest relationships were between 40-yard sprint speed and all RWE-Game metrics (all P ≤ 0.0001 and partial R
2 > 0.3). The only significant relationships among HIE metrics in practice were between shuttle run speed and total practice impacts and RWELinear-Practices, 40 yard sprint speed and total number of practice impacts, and three-cone speed and 95th percentile number of impacts/practice.

Conclusions

Generally, higher vertical jump height and faster times in speed and agility drills were associated with higher HIE, especially in games. Physical performance explained less variation in HIE in practices, where drills and other factors, such as coaching style, may have a larger influence on HIE.
When Work Disappears: Manufacturing Decline and the Falling Marriage Market Value of Young Men
Authors: Autor David , Dorn David , Hanson Gordon
Published: August 2019

We exploit the gender-specific components of large-scale labor demand shocks stemming from rising international manufacturing competition to test how shifts in the relative economic stature of young men versus young women affected marriage, fertility, and children’s living circumstances during 1990–2014. On average, trade shocks differentially reduce employment and earnings of young adult males. Consistent with Becker’s model of household specialization, shocks to males’ relative earnings reduce marriage and fertility. Consistent with prominent sociological accounts, these shocks heighten male idleness and premature mortality, and raise the share of mothers who are unwed and the share of children living in below-poverty, single-headed households. (JEL F16, J12, J13, J16, J23, J31, L60)
Bone islands incidentally detected on computed tomography: frequency of enostosis and differentiation from untreated osteoblastic metastases based on CT attenuation value
Authors: Sala Francesco , Dapoto Annarita , Morzenti C. , firetto Maria cristina , Valle Clarissa , Tomasoni A. , Sironi Sandro
Published: August 2019

Objective:

The frequency of enostosis incidentally found on CT and CT attenuation value to distinguish them from untreated osteoblastic metastases (UOM).

Methods:

Enostosis group: 46 polytrauma patients underwent thoracoabdominal CT. Inclusion criteria: age range 14–35 years. Exclusion criteria: cancer, previous fractures. UOM group: 20 patients with radiological diagnosis of UOM. Analyzed data: number, size, location and density of enostoses and metastases. The density was measured with the broadest possible region of interest at the center of the lesion by two radiologists independently. Receiver operatingcharacteristic analysis to determine the sensitivity and specificity, area under the curve 95% confidence intervals and cutoff values of CT density to differentiate metastases from enostoses.

Results:

Patients were 28 ± 7 years old (72% males). 41 (89%) patients had 124 enostoses (2–15 mm) with an average density of 1007 ± 122 Hounsfiled unit (HU, observer1) and 1052 ± 107 (observer2). The most common sites of occurrence were the proximal femur (34%), the pelvis (22%), the acetabulum (20%), the proximal humerus (11%), the vertebrae (11%) and the rib (2%). 13 patients had 1 bone island, 8 patients had 2, 9 cases had 3 and 11 cases had more than 3 enostoses. Overall, 114 UOM were evaluated, their average density was 728 ± 163 HU (observer1) and 712 ± 178 HU (observer2). The area under the curve value of mean density to distinguish enostoses from UOM was 0,982. Using a cut-off of 881 HU for mean density, sensitivity was 98% and specificity 95%.

Conclusion:

The frequency of enostosis in this study is 89%. The average density identified can help to distinguish enostoses from UOM.

Advances in knowledge:

We report the exact frequency of enostosis.
Registration accuracy with the low dose kilovoltage cone-beam CT: A phantom study
Authors: Takei Yoshiki , Monzen Hajime , Matsumoto Kenji , Hanaoka Kohei , Tamura Mikoto , Nishimura Yasumasa
Published: August 2019

Objective:

The aim of this study was to investigate low-dose kilovoltage cone-beam CT (kV-CBCT) for image-guided radiotherapy, with a particular focus on the accuracy of image registration with low-dose protocols.

Methods:

Imaging doses were measured with a NOMEX semiconductor detector positioned at the front of head, thorax, and pelvis human body phantoms while kV-CBCT scans were acquired at different tube currents. Aspects of image quality (spatial resolution, noise, uniformity, contrast, geometric distortion, and Hounsfield unit sensitivity) and image registration accuracy using bone and soft tissue were evaluated.

Results:

With preset and the lowest tube currents, the imaging doses were 0.16 and 0.08 mGy, 5.29 and 2.80 mGy, and 18.23 and 2.69 mGy for head, thorax, and pelvis, respectively. Noise was the only quality aspect directly dependent on tube current, being increased by 1.5 times with a tube current half that of the preset in head and thorax, and by 2.2 times with a tube current 1/8 of the preset in the pelvis. Accurate auto-bone matching was performed within 1 mm at the lowest tube current. The auto-soft tissue matching could not be performed with the lowest tube current; however, manual-soft tissue matching could still be performed within 2 mm or less.

Conclusion:

Noise was the only image quality aspect dependent on the imaging dose. Auto-bone and manual-soft tissue matching could still be performed at the lowest imaging dose.

Advances in knowledge:

When optimizing kV-CBCT imaging dose, the impact on bone and soft tissue image registration accuracy should be evaluated.
Adoption of management decisions based on programming methods as a subgroup of methods for optimizing performance indicators
Authors: Тебекин А. , Tebekin A.
Published: August 2019

The author's classification of management decision-making methods, including twenty-five classes of methods, is presented for the first time. As part of the general classification of management decision-making methods, the role and place of a group of methods for making managerial decisions based on the optimization of performance indicators was demonstrated. In the group of methods for making managerial decisions based on the optimization of performance indicators, a subgroup of programming methods (linear, nonlinear and dynamic) is considered in detail. The features of use and application are shown when making managerial decisions of a subgroup of programming methods.
Creating a working project of a web-application for training in programming at the initial stage of professional training
Authors: Злыднева Татьяна , Zlydneva T.
Published: August 2019

The article gives the analysis of the main provisions of the training manual "Software for computer networking and web-servers" of the authors G.A. Lisiev, P.Yu. Romanov, Yu.I. Askerko, which is published in the series "Secondary vocational education". Important aspects of the technology of project training are noted. The article presents the developed by the authors educational and me-thodical material for the consistent implementation of the web-project in teaching programming in high-level languages of students of secondary vocational education.
Prospects for managing Russia's foreign trade activity against the background of shifts in the EU development
Authors: Царев Сергей , Carev Sergey , Горбатенко Елена , Gorbatenko Elena
Published: August 2019

This article discusses the most pressing problems faced by the Russian Federation in the implementation of its foreign trade policy in the framework of commodity exchange with the European Union (EU) from the standpoint of improving the management of these processes. The modern characteristics of mutually beneficial trade of the EU member States and the Russian Federation are analyzed. The most significant changes in the EU foreign trade practice are revealed.
Waste management "Smart city", with the help of technological intelligent systems
Authors: Владимиров Д. , Vladimirov D. , Воротников Александр , Vorotnikov Aleksandr , Ипатова Н. , Ipatova N. , Тарасов Б. , Tarasov B.
Published: August 2019

The article discusses the possibilities and prospects of using digital technologies in the management of solid waste management system. The possibility of using intelligent control systems in this activity is shown.
Understanding User-Generated Content and Customer Engagement on Facebook Business Pages
Authors: Yang Mochen , Ren Yuqing , Adomavicius Gediminas
Published: August 2019

With the growth and prevalence of social media platforms, many companies have been using them to engage with customers and encourage user-generated content about their products and services. In this paper, we analyze user-generated posts from the Facebook business pages of multiple companies across several industries to understand what users post on Facebook business pages and how post valence and content characteristics affect engagement, measured as the number of likes and comments received by a post. Our analysis demonstrates that negative posts are significantly more prevalent than positive posts, and negative posts also tend to attract more likes and more comments than positive posts. Importantly, engagement depends not only on the valence of a post but also on the specific post content. We observe three types of customer complaints respectively related to product and service quality, money issues, and corporate social responsibility issues. We show that social complaints receive more likes, but fewer comments, than quality or money complaints. Our findings reveal the practical challenges of managing Facebook business pages as a new channel of interacting with customers, and they highlight the need to explore effective response strategies to manage customer complaints and other service requests on social media.
Inflexible Repositioning: Commitment in Competition and Uncertainty
Authors: Cong Jiajia , Zhou Wen
Published: August 2019

We study the value of commitment in a business environment that is both competitive and uncertain, in which two firms face stochastic demands and compete in positioning and repositioning. If the future demand tends to disperse or the demand uncertainty is sufficiently large, one firm chooses rigidity (i.e., commits not to change its positions), and the other chooses flexibility (i.e., to reposition freely). We find that a firm’s rigidity can benefit not only itself, but also its flexible rival. When uncertainty is larger, rigidity becomes more valuable relative to flexibility. These results arise because the asymmetric equilibrium generates two collective gains in addition to the usual individual gain (in terms of competitive advantages) accrued to the committing firm. A firm’s rigid repositioning can soften competition and generate a commitment value, and the other firm’s flexible repositioning generates an option value. Both values then spill over to competitors within the ecosystem. These results suggest that, when firms compete under uncertainty, commitment and options are valuable not only for the party that is making the choice, but also for all competing parties collectively. Commitment value and option value do not have to be mutually exclusive; they can coexist and even strengthen each other through unilateral commitment, which achieves the best of both strategies.

This paper was accepted by Juanjuan Zhang, marketing.
O FORTALECIMENTO DA GOVERNANÇA E DA EFICIÊNCIA NOS SERVIÇOS PÚBLICOS BRASILEIROS NAS TRANSIÇÕES DE GOVERNO
Authors: Tiago Carlos Eduardo Vilela , Rohm Ricardo Henry Dias
Published: August 2019

O presente trabalho tem como objetivo realizar uma análise da gestão pública brasileira e apontar algumas alternativas viáveis com vistas a fortalecer a governança pública e melhorar a eficiência na gestão dos serviços públicos brasileiros em períodos de transição de governos. Tendo em vista a fragilidade da estrutura administrativa durante o processo de mudança de governo e diante da escassez de artigos e livros publicados pela comunidade acadêmica, este trabalho pretende colaborar para o preenchimento desta lacuna existente, além de propor e incentivar outros estudos e linhas de pesquisa nesta seara do conhecimento científico em Administração Pública e Governança. Para tal, realizou-se uma pesquisa bibliográfica, contemplando artigos científicos, livros e periódicos publicados, e compilando tais informações em uma matriz de critérios lógicos e metodológicos. Analisou-se o contexto político e gerencial da seara da gestão pública brasileira, enfatizando as implicações em termos da tomada de decisão e da eficiência na gestão da máquina pública em momentos de mudanças administrativas e políticas decorrentes de transições de governos. Tal analise visa clarificar o leitor quanto à forma como é estudado e aplicado o assunto atualmente, revelando os desafios que terão que ser enfrentados pela Administração Pública com vistas a fortalecer a eficiência e a governança na aplicação de seus recursos diante de cenários de transição administrativa. Ao final, foram apontadas algumas oportunidades de melhoria a fim de incrementar a eficiência em períodos de transição e foram identificadas sugestões para estudos futuros acerca da temática tratada.
LODO DE ESTAÇÃO DE TRATAMENTO DE ESGOTO (ETE) E COMPOSTAGEM ORGÂNICA EM CULTIVO DE MUDAS NATIVAS: ESTUDO NA REGIÃO DOS LAGOS RJ - BRASIL
Authors: Coelho Thamylla Rodrigues , Da Silva José Augusto Ferreira , Dias Marcelo Vizeu
Published: August 2019

O lodo proveniente do tratamento de esgotos é um problema ambiental decorrente de um crescente aumento do volume resultante do tratamento. A disposição do resíduo na agricultura é permitida, graças aos efeitos positivos demonstrados nas pesquisas, em conjunto com procedimentos dispostos pelo Poder Público para seu gerenciamento. Foram destacadas na revisão bibliométrica, os pontos principais para o emprego do lodo, limitações, benefícios, sua importância como ferramenta de auxílio na recuperação de áreas degradadas e substrato florestal, além das experiências bem sucedidas em diferentes formas de aproveitamento. Após apurar os indicativos positivos, podemos promover o emprego do biossólido na Região dos Lagos de forma sustentável em atividades autorizadas, permitindo a viabilidade socioambiental do composto.
A participação das mulheres na produção acadêmica da área de Relações Internacionais no Brasil | The participation of women in academic production in the field of International Relations in Brazil
Authors: Coelho Farias de Souza André Luiz , Elias Ivi Vasconcelos , Santos Vinicius Silva
Published: August 2019

Neste artigo, buscamos mapear a produção acadêmica na área de Relações Internacionais no Brasil observando a participação das mulheres partindo das características da produção acadêmica em relação ao gênero e às divisões temáticas do campo. Para tanto, analisamos os dois principais periódicos da área segundo a classificação da Capes: Contexto Internacional e a Revista Brasileira de Política Internacional (RBPI). O artigo está dividido em três partes. Na primeira, situamos a discussão sobre mulheres na ciência em relação ao gênero como categoria crítica de análise. Em seguida, promovemos o debate sobre a literatura que discute o mapeamento da produção acadêmica, considerando a produção científica de mulheres em geral e na área de Relações Internacionais. Finalmente, apresentamos os resultados situando a produção acadêmica feminina. Como conclusão, constatamos que a distância do número de artigos publicados por mulheres e homens não se alterou ao longo do tempo, mantendo a estrutura de desigualdade.Palavras-chave: Gênero; Relações Internacionais no Brasil; Produção Acadêmica. ABSTRACTIn this article, we seek to map the academic work in the field of International Relations in Brazil, according to women’s share focusing on the characteristics of the academic work in relation to gender and thematic divisions in the field. We analyzed all the articles published by two of the most prestigious journals in Brazil: Contexto Internacional e Revista Brasileira de Política Internacional (RBPI). The article has three sections: the first presents the discussion about women in science and brings gender as a critical analytical category. In the following section, we carry out a debate about the literature which deals with the mapping of academic production considering the scientific production. Finally, we present the results placing the female academic production. In the end, our findings show that the gap between the number of articles published by men and women did not change over time maintaining the structure of inequality.Keywords: Gender; International Relations in Brazil; Academic Production.Recebido em: 19 set.2018 | Aceito em: 31 mai.2019
Risk of cardiovascular disease in people taking psychotropic medication: a literature review
Authors: Mwebe Herbert , Roberts Danielle
Published: August 2019

In people with serious mental illness, mortality and morbidity are significantly increased compared to the general population. This is often as a result of physical health problems; about two-thirds of premature death in people with serious mental illness has been attributed to natural causes including cardiovascular disease and diabetes. Cardiovascular disease risk in people with serious mental illness is higher than the general population, this risk is further increased in those with serious mental illness taking psychotropic medication. In this article, cardiovascular disease risk in serious mental illness, particularly the association with psychotropic interventions and monitoring required, is examined.
SPN Graphs
Authors: Hogben Leslie , Shaked-Monderer Naomi
Published: August 2019

A simple graph G is an SPN graph if every copositive matrix having graph G is the sum of a positive semidefinite and nonnegative matrix. SPN graphs were introduced in [N. Shaked-Monderer. SPN graphs: When copositive = SPN. Linear Algebra Appl., 509:82{113, 2016.], where it was conjectured that the complete subdivision graph of K4 is an SPN graph. This conjecture is disproved, which in conjunction with results in the Shaked-Monderer paper show that a subdivision of K_4 is a SPN graph if and only if at most one edge is subdivided. It is conjectured that a graph is an SPN graph if and only if it does not have an F_5 minor, where F_5 is the fan on five vertices. To establish that the complete subdivision graph of K_4 is not an SPN graph, rank-1 completions are introduced and graphs that are rank-1 completable are characterized.
Participatory filmmaking in voluntary sector research: innovative or problematic?
Authors: Terry Vita , Jolly Andrew
Published: August 2019

This paper draws both on the authors’ experiences of making a participatory film exploring collective leadership in diverse communities, and on a world café style workshop at the 2018 Voluntary Sector and Volunteering Research Conference organised by the National Council
for Voluntary Organisations and the Voluntary Sector Studies Network. The intention is to provoke dialogue about the opportunities and challenges of participatory filmmaking as a research method, and whether it is an appropriate methodological approach for voluntary sector research, with the
potential to advance thinking on about and the use of mixed-media methods.
Use of Silica Gel from Volcanic Ash as Chitosan Composite Membrane’s Filler
Authors: Lubis Maulida , Sukeksi Lilis , Harahap Mara Bangun , Ginting Melva , Wici Herlinawati , Ayu Ghendis E
Published: August 2019

This study aims to determine the process of making composite membranes of chitosan and silica fillers from volcanic ash of Sinabung mountain and determine the physical properties of chitosan composite membranes viz. degree of water absorption, functional groups. In this study, composite membranes were made using phase inversion method with the composition of chitosan and silica used were 2 g of chitosan and variations in dosage of fillers 0.6, 0.9 and 1.2 g of silica, while the stirring time was 8, 12 and 16 h. Based on the results , the best membrane conditions were obtained from
composite membrane analysis with the best conditions of composite membranes at water absorption is 44.58 %. From the results of FTIR analysis, indicated the presence of OH bonds and Si-O-Si bonds on composite membranes caused by silica gel characteristics of composite membranes also supported by EDX analysis showed composite membrane contained carbon 55.17 %, oxygen 20.36 % and silicon 10.42 %.
Synthesis of Antibiotic Penicillin-G Enzymatically by Penicillium chrysogenum
Authors: Nawfa Refdinal , Purnomo Adi Setyo , Putro Herdayanto Sulistyo
Published: August 2019

Penicillin-G antibiotic was used as the basic ingredient of making antibiotic type β-lactam such as tetracycline, amoxicillin, ampicillin and other antibiotics. Penicillin-G was splited into 6-amino penicillanic acid as the source of β-lactam. The biosynthetic pathway for the formation of penicillin-G in Penicillium chrysogenum cell through the formation of intermediates was carried out in the form of amino acids such as α-aminoadipate, L-cysteine, L-valine which are formed from glucose (food ingredients).The formation of 6-amino penicillanic acid is an amino acid combination of L-cysteine and L-valine, a step part of the formation of antibiotic penicillin-G in P. chrysogenum cells, thus, it is obvious that there are enzymes involved in its formation. The objective of this study was to examine the use of enzymes present in P. chrysogenum cells to produce penicillin-G and 6-amino penicillanic acid using the intermediate compounds α-aminoadipate, L-cysteine, L-valine and phenylacetic acid assisted by NAFA® coenzymes in P. chrysogenum cells which is more permeable. The research method started from producing biomass of P. chrysogenum cells that demonstrated penicillin-producing antibiotic capability, as the source of the enzyme, followed by addition of permeability treatment of P. chrysogenum cell membrane to get immobile of enzyme by its own cell therefore it can be used more than once. After that the enzyme activity was proven by adding α-aminoadipate, L-cysteine, L-valine, phenylacetic acid and NAFA® coenzyme for the formation of penicillin-G, whereas the addition of L-cystein, L-valine and NAFA® coenzyme were aimed to form 6-amino penicillanic acid. The results showed that P. chrysogenum is able to produce antibiotics with stationary early phase on day 6. The best increased permeability of P. chrysogenum cell membranes was obtained using a 1:4 of toluene:ethanol ratio mixture with the highest antibiotic concentration (130.06 mg/L) after testing for the enzymatic formation of antibacterial penicillin-G.
Synthesis and Biological Evaluation of Furo[3,2-c]pyrazole-5-carbimidates
Authors: Siliveri Sravanthi , Vamaraju Harinadha Babu , Shivaraj
Published: August 2019

In the present work, novel pyrazole fused dihydrofurans synthesized via a chronological addition of N-chloro succinimide and base piperidine to pyrano[3,2-c]pyrazole carbonitrile derivatives in methanol medium. Oxidative difunctionalization was done with the reagent N-chloro succinimide by the addition of both chlorine and alkoxy groups crosswise the chromene double bond. The addition of base results in the construction of dihydrofuran derivatives by ring contraction. The structures of newly synthesized compounds were characterized on the basis of physical and spectral data. Synthesized compounds were evaluated for antibacterial and anti-inflammatory activities. All the compounds exhibited significant antibacterial activity against all the four strains of bacteria and their MICs ranged between 1.56 and 12.55 μg/mL. In anti-inflammatory screening, among all the tested compounds, compounds 7, 8, 9, 11, 12, 13, 14, 16, 17 and 18 exhibited significant protection against the edema formation at a concentration of 100 mg/kg.
Synthesis of Eco-Friendly Detergent Based on Crude Palm Oil and Titania Nanoparticles
Authors: Wulandari P.P. , Adiwibowo M.T. , Redjeki A.S. , Ibadurrohman M. , Slamet
Published: August 2019

In this work, we report the synthesis of eco-friendly detergent from crude palm oil and titania. Crude palm oil was converted into methyl ester sulfonate through esterification, transesterification and followed by sulfonation process. As-produced methyl ester sulfonate was characterized with Fourier transformed infrared spectroscopy (FTIR), gas chromatography-mass spectroscopy (GC-MS), liquid chromatography mass spectroscopy (LCMS) and surface tension analysis. Detergents were synthesized
by dispersing titania nanoparticles into methyl ester sulfonate solution, forming a nanofluid. Stability and detergency of the nanofluidic detergents were then evaluated. The results showed that the nanofluid detergents were stable in the presence of 0.1 wt % titania and the photocatalytic activity of titania nanoparticles improved the ability of nanofluidic detergents to remove dirt as well as degrading the surfactant residues in the laundry waste stream.
Synthesis, Characterization and in vitro Antimicrobial, Antioxidant and Anticancer Activity of Random Copolyester Using 1,4-Dithiane-2,5-diol
Authors: Kalpana B. , Nanthini R.
Published: August 2019

A random copolyester was prepared by direct melt polycondensation method using 1,4-dithiane-2,5-diol, 1,4-cyclohexane diol and Sebacic acid in the mole ratio 1:1:2 using titanium tetra isopropoxide as catalyst. The synthesized copolyester poly(1,4-dithiane-2,5-diol sebacate–co–1,4-cyclohexane diol sebacate) (PDCSe) was characterized by FT-IR, 1H NMR and 13C NMR to determine the chemical structure, while wide angle XRD, differential scanning spectroscopy and Inherent viscosity were determined to study its physical properties. Further the antioxidant, antimicrobial and anticancer activities of the synthesized copolyester were determined to study its biological property.