bluuebunny/crossref_metadata_2025 huggingface dataset:
Pathogenesis of Collagen-Induced Arthritis: Role of Immune Cells with Associated Cytokines and Antibodies, Comparison with Rheumatoid Arthritis
Authors: Šteigerová Monika , Šíma Martin , Slanař Ondřej
Published: December 2023

Collagen-induced arthritis is the most com­monin vivomodel of rheumatoid arthritis used for investigation of new potential therapies in preclinical research. Rheumatoid arthritis is a systemic inflammatory and autoimmune disease affecting joints, accompanied by significant extra-articular symptoms. The pathogenesis of rheumatoid arthritis and collagen-induced arthritis involves a so far properly unexplored network of immune cells, cytokines, antibodies and other factors. These agents trigger the autoimmune response leading to polyarthritis with cell infiltration, bone and cartilage degeneration and synovial cell proliferation. Our review covers the knowledge about cytokines present in the rat collagen-induced arthritis model and the factors affecting them. In addition, we provide a comparison with rheumatoid arthritis and a description of their important effects on the development of both diseases. We discuss the crucial roles of various immune cells (subtypes of T and B lymphocytes, dendritic cells, monocytes, macrophages), fibroblast-like synoviocy­tes, and their related cytokines (TNF-α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-17, IL-23, GM-CSF, TGF-β). Finally, we also focus on key antibodies (rheu­matoid factor, anti-citrullinated protein antibodies, anti-collagen II antibodies) and tissue-degrading enzymes (matrix metalloproteinases).
HOFSTEDE'NİN SERBESTLİĞE KARŞI SINIRLILIK BOYUTUNUN TÜRKÇE ÖLÇEĞE UYARLANMASI
Authors: Can Esin , Özer Elif , Urfa Ayşe Merve
Published: December 2023

Geert Hofstede tarafından literatüre kazandırılan kültürel boyutlar teorisine en son eklenen serbestlik-sınırlılık boyutu, toplumların mutluluk temaları ve yaklaşımlarına odaklanmıştır. Serbestlik boyutu, bireylerin kişisel ihtiyaç ve isteklerini gerçekleştirmelerinin değerli olduğunu, bireysel mutluluğu ve iyi oluşu önceliklendiren toplumları temsil ederken; sınırlılık boyutu toplumsal normlara uyumlu olmak için bireysel istek ve ihtiyaçlarını sınırlandıran toplumları temsil etmektedir. Yapılan incelemeler sonucunda serbestlik-sınırlılık boyutuna ait Türkçe literatürde uyarlaması yapılmış veya geliştirilmiş bir ölçek bulunmadığı görülmüştür. Kültür boyutlarının birçok alanı etkileyici bir unsur olarak görülmesi sebebiyle, konuyla ilgili ölçek geliştirme ve uyarlama çalışmalarının literatürü zenginleştirecek araştırmalara yardımcı olacağı düşünülmektedir. Bu bağlamda, Heydari vd. (2021) tarafından geliştirilen serbestlik-sınırlılık ölçeğine ait ifadeler kullanılarak, bireysel düzeydeki serbestlik-sınırlılık ölçeğinin Türkçe‘ye uyarlanması amaçlanmıştır. Araştırma Türkiye Cumhuriyeti vatandaşı olan 18 yaş üzeri bireyler üzerinde gerçekleştirilmiştir. Çalışmada beş aşamalı tersine çeviri yöntemi kullanılmış olup, birinci çeviri çalışması, birinci çeviriyi değerlendirme süreci, tersine çeviri çalışması, tersine çeviriyi değerlendirme süreci ve uzman görüşlerinden oluşan süreç izlenmiştir. Uyarlanan Türkçe ölçeğin SPSS 26.0 ve AMOS programları kullanılarak geçerlilik ve güvenilirliği analiz edilmiştir. Veri analizleri sonucunda, ölçeğin Türkçe uyarlamasının güvenilir ve uygulanabilir olduğu sonucuna ulaşılmıştır.
Ensuring quality in 17OHP mass spectrometry measurement: an international study assessing isomeric steroid interference
Authors: Ho Chung Shun , Hoad Kirsten , Cooke Brian R. , Andersen Trisha , Graham Peter , van den Berg Sjoerd A.A. , Hartmann Michaela F. , Lo Clara W.S. , Loh Tze Ping , de Rijke Yolanda B. , van Zelst Bertrand D. , Wudy Stefan A. , Zakaria Rosita , Greaves Ronda F.
Published: December 2023

Objectives

Interference from isomeric steroids is a potential cause of disparity between mass spectrometry-based 17-hydroxyprogesterone (17OHP) results. We aimed to assess the proficiency of mass spectrometry laboratories to report 17OHP in the presence of known isomeric steroids.

Methods

A series of five samples were prepared using a previously demonstrated commutable approach. These samples included a control (spiked to 15.0 nmol/L 17OHP) and four challenge samples further enriched with equimolar concentrations of 17OHP isomers (11α-hydroxyprogesterone, 11β-hydroxyprogesterone, 16α-hydroxyprogesterone or 21-hydroxyprogesterone). These samples were distributed to 38 participating laboratories that reported serum 17OHP results using mass spectrometry in two external quality assurance programs. The result for each challenge sample was compared to the control sample submitted by each participant.

Results

Twenty-six laboratories (68 % of distribution) across three continents returned results. Twenty-five laboratories used liquid chromatography-tandem mass spectrometry (LC-MS/MS), and one used gas chromatography-tandem mass spectrometry to measure 17OHP. The all-method median of the control sample was 14.3 nmol/L, ranging from 12.4 to 17.6 nmol/L. One laboratory had results that approached the lower limit of tolerance (minus 17.7 % of the control sample), suggesting the isomeric steroid caused an irregular result.

Conclusions

Most participating laboratories demonstrated their ability to reliably measure 17OHP in the presence of the four clinically relevant isomeric steroids. The performance of the 12 (32 %) laboratories that did not engage in this activity remains unclear. We recommend that all laboratories offering LC-MS/MS analysis of 17OHP in serum, plasma, or dried bloodspots determine that the isomeric steroids are appropriately separated.
Query optimization-oriented lateral expansion method of distributed geological borehole database
Authors: Luo Qingjia
Published: December 2023

In order to reduce the resource occupancy and retrieval efficiency of geological drilling databases, this study proposes a distributed horizontal expansion method for query optimization of geological drilling databases by constructing a comprehensive geological data subtree, analyzing the characteristics of distributed databases and elements in geological databases, and quickly retrieving data resources based on element attributes. In addition, this study has designed a method to horizontally extend the database designed for drilling holes using a multi-constraint model in order to achieve extension optimization of the distributed geological drilling database. Experiments are conducted to verify the performance and applicability of the proposed method. The experiment shows that when the geological data capacity is 80 GB, the capacity level of the geological database can be extended to 41 × 105TB using the method proposed in this study. The retrieval efficiency is higher than 89% and the resource occupancy rate is lower than 12% after the horizontal expansion of the database. By using this research method, the horizontal expansion of the geological drilling database is more effective, and can effectively reduce the resource occupancy rate and retrieval efficiency of the geological drilling databases. This has value significance for geological drilling with efficiency improvement and development.
“The Authors” Make Me Think Equally of Women and Men: Exploring Mixed-Gender Representations in a Visual Categorisation Task
Authors: Kim Jonathan D. , Öttl Anton , Gygax Pascal , Behne Dawn M. , Hyönä Jukka , Gabriel Ute
Published: December 2023

A common goal for gender-fair language policies is to promote terms that elicit balanced activation of gender categories. Expanding previous research on the activation of feminine versus masculine categories through person nouns, we used a word-picture response priming design with gendered human faces as target stimuli, to explore whether a simultaneous activation of more than one gender category can be captured empirically. Focusing on Norwegian (Bokmål), we tested whether reading stereotypical (i.e. role nouns, e.g. “care givers”) and categorical gendered person nouns (i.e. name pairs, e.g. “Elin and Sandra”) facilitates the categorisation of face pairs that match the gender of the designated people. In Experiment 1 (N = 32), gender-specific (feminine or masculine) word primes were tested, before gender-balanced word primes (non-stereotyped role nouns; pairs of a female and a male name) were added in Experiment 2 (N = 39). In both experiments, the visual targets were pairs of faces (two female faces, two male faces, or one male and one female face). Consistent with previous results for English, we found gender-specific priming effects, supporting the notion that gender categories activated by linguistic stimuli may also exert influence outside of language processing. Most importantly, mixed-gender faces were successfully primed by non-stereotypical role nouns providing initial support for the idea of a balanced activation of gender categories.
Machiavellis Kriegskunst: Die Lehren des Libro dell’arte della guerra
Authors: Frömmer Judith
Published: December 2023

For the most part, Machiavelli’s Libro dell’arte della guerra has been studied as a military treatise, which had produced different interpretations and applications. Whereas military historians assumed that Machiavelli somewhat underestimated the role of the so-called gunpowder revolution, recent scholarship stresses the political dimensions of the text and its reception in different contexts. This article focuses on the poetics of the dialogue, which cannot be reduced to propositional contents. Instead of teaching specific strategies and tactics of warfare, the Libro engages its readers in a military dialogue in a more radical sense. It enacts the very dynamics of war and battle by staging the complex and often contradictory conditions and foundations of speech and (military and political) theory on the one hand and its potential interactions with conflicting historical realities on the other. By combining different generic traditions of the literary dialogue from Plato to Cicero and Petrarch it performs a Machiavellian arte della guerra as the very form of military and militant intervention which concerns not only the practice of warfare, but human activity as such.
Ziel und Zweck als Ursachen im Siglo de Oro
Authors: Strosetzki Christoph
Published: December 2023

Teleological thinking dominates in the early modern period. According to Aristotle, man’s goal is happiness in the community. For Hobbes, who sees man as a wolf, there is no such goal. Whereas in antiquity Xenophon had spoken of a universal purposefulness in which the goal of all things is usefulness to man, the goal cause pre-exists as thought in the consciousness of man, whereby idleness is to be rejected. The merchant pursues the goal of supplying the community with goods that are not locally available. In money lending, the main goal can be charity and the hope of profit is only the secondary goal. The military’s objective is to prevent peace and to restore the disturbed order in a just war. If, according to Perez de Moya, the multitude of stars have the purpose of serving illumination at night, decorating the sky, or influencing things on earth, for example, by causing disease in humans, then they are also relevant to medical activity. Since the soul is purpose for the body, diseases are reactions to negative affects of the soul, such as anger or fear.
Impacto do uso de dispositivos eletrônicos na visão das crianças em idade escolar
Authors: Carneiro Bruna Ribeiro , Skonieczny Nattally Edimeire , Spinello Analice Horn , Candido de Bortoli Cleunir de Fátima
Published: December 2023

Objetivo: conhecer o impacto das telas sobre a acuidade visual das crianças em idade de quatro a 12 anos, na perspectiva dos pais e responsáveis. Método: estudo quantitativo, descritivo, com 176 participantes. O convite ocorreu por mensagens enviadas nas redes sociais e a coleta através de um questionário online, entre fevereiro e abril de 2021. A análise ocorreu pelas frequências simples dos dados.  Resultados: 50,57% tiveram o primeiro contato com as telas, antes de dois anos de idade. As queixas mais frequentes após uso de telas são: dores de cabeça, irritação visual, olhos ressecados e lacrimejando, visão turva e tonturas.  20,45% das crianças possuem dificuldades com de visão em grandes distancias e 60,80% das crianças, já realizaram avaliação oftalmológica. Conclusão: há um crescente número de crianças expostas precocemente e durante prolongados períodos, aos aparelhos eletrônicos de forma demasiada.
Seed Science and Technology. Volume 51 Issue 3 (2023)
Authors: Srii V. Satya
Published: December 2023

This issue of Seed Science and Technology has a collection of articles that contribute to seed quality, which will be of interest to both farmers and the seed industry. The articles span diverse topics: germination treatments, vigour testing methods, viability equations and management
of seed-borne inoculum. However, the majority of articles focus on germination treatments to break dormancy and provide uniform field emergence. Besides this, a review article on seed quality enhancement using seed priming will be highly informative to seed producers to enhance seed quality
and hence benefit farmers in particular in developing countries. Many of the species studied are less explored and some are on the verge of extinction, requiring immediate attention. Overall, this issue will be of interest to a wide range of readers, including farmers, seed companies, researchers
and conservationists.
Microscópio eletrônico de varredura e Luminol/DNA como ferramentas na elucidação de caso de franco atirador em São Paulo
Authors: Santos Lopes Leandro
Published: December 2023

A máxima do Princípio de Locard, de que todo contato deixa uma marca, é muito popular entre profissionais da criminalística, porém, muitas vezes, não é exercida em seu sentido mais amplo. Comumente, a análise de um local de crime restringe-se à busca de vestígios deixados pelo autor, ignorando possíveis elementos presentes no ambiente que foram transferidos ao criminoso. Este relato de caso, tem por fim, demostrar a utilização prática desse princípio em que foi possível estabelecer a correlação de um suspeito com um local de duplo homicídio consumado e homicídio tentado com utilização de arma de fogo. O objeto de análise foi o calçado de um suspeito, utilizando-se o exame com o emprego de Luminol, para orientar a pesquisa de sangue no solado, análise de DNA das regiões quimioluminescentes ao Luminol e por fim, microscópio eletrônico de varredura para pesquisa de fragmentos de vidro. Ambos apontaram elementos comuns ao local de crime e solado do calçado do suspeito, indicando que este esteve no local dos fatos durante/após o delito, pisando no sangue de uma das vítimas fatais e também em fragmentos de vidro presentes na entrada do estabelecimento. Tais resultados comprovam a necessidade de se atentar a micro vestígios que podem estar presentes com suspeitos, principalmente em calçados.
Production of micro-lignocellulosic fibril rubber composites and their application in coated layers of building materials
Authors: Teangtam Sarocha , Yingprasert Wissanee , Somboon Phichit
Published: December 2023

Novel composite materials were made by combining micro-lignocellulosic fibrils and natural rubber applied as spray coated layers for building materials. The micro-lignocellulosic fibrils were produced based on the mechanical pulping process with jute bast as the raw material. The obtained micro-lignocellulosic fibrils had a good content of water-suspended materials with fibril widths of about 0.1 to 1.0 µm and fibril length of about 100 to 150 µm. The composites were produced using natural rubber mixed with the micro-lignocellulosic fibrils at 0, 5, and 10 parts per hundred of rubber, vulcanizing sulfur, and activated zinc oxide. The fibril-rubber suspension was formed in the composite sheets with a thickness of 0.5 to 1.5 mm using a spray coating technique and was oven-dried at 100 °C. The rubber composite had a homogenous fibril distribution in the rubber composite matrix, with good bonding between the fibrils and the rubber polymers. The fibrils contributed to the strength reinforcement of the rubber composite layers. The application of the micro-lignocellulosic fibril rubber composites coated onto industrial fiber cement boards enhanced the thermal insulation properties, which had a lower degree of thermal conductivity and heat diffusivity and enhanced the toughness and waterproofing of the fiber cement boards.
Degradation of Polyester Composite Reinforced E-Glass Fiber with Calcium Carbonate Filler in Seawater
Authors: Nasir Mohamad , Fajrin Jauhar
Published: December 2023

This research is concerned with composite materials that use CaCO3 as a reinforcing material in construction, especially subsea panels and buildings. Composite materials are solids composed of two or more materials that have their own properties and improve their properties when combined. In this experiment, glass fiber and CaCO3 were mixed in a certain composition and tested to evaluate the water absorption and mechanical strength of the composite. The results show that increasing temperature can increase water absorption, while the addition of CaCO3 has a significant effect on water absorption due to its hydrophilic properties. Water absorption in polyester composites is influenced by aging temperature and Calcium Carbonate powder filler, affecting tensile and bending strength. As aging temperature increases, mechanical strength decreases, composite having the highest tensile strength. Bending tests show debonding and splitting fault patterns due to glass fiber arrangement. With a deeper understanding of how CaCO3 affects composite materials under various conditions, this research can provide valuable insights for developing more durable composite materials suitable for construction applications, especially in corrosive environments such as subsea buildings.In this research, it proposes theoretically model to controlling on half-wave voltage of modulator, in which it uses studying the factor of effective of refractive index difference, this using analysis distribution of refractive index for LN material before and after voltage is applied (i.e., with and without applied voltage), and uses analysis a factor of propagation constant difference ??, before and after voltage is applied where it depends on the wavelength, these leads to it controls on the half-wave voltage V? using a reduction half-wave voltage up to 1V. Also, it achieves an excellent solution for solve the fundamental optical mode with effective factor is neff. Finally, the modulator with an effect effective refractive index difference have lower applied voltage up to 10V, and with an effective propagation constant difference the operating voltage is from value of 20V.
Expression and Purification of Recombinant T7 RNA Polymerase in Escherichia Coli
Authors: Hjazi Ahmed , Alqarni Ahmad Ali Musa , Alfahed Abdulaziz , Abusalim Ghadah S. , Shmrany Humood Al , Alqasem Abdullah A. , Hjazi Bader M , Alobaisi Yousef sultan , Aloraini Ghfren S. , Walsaeer Piers
Published: December 2023

T7 RNA polymerase, DNA dependent RNA polymerase commonly employed in virus molecular research, in vitro transcription and virus replication. The aim of this study was to produce a recombinant T7 RNA polymerase enzyme employing an E. coli protein expression system. In addition, this project aimed to establish and optimize high-yield expression of soluble recombinant T7 RNA polymerase in E. coli cells. Escherichia coli are the most commonly used protein expression systems because of the ease of cultivation, high yield, and low cost. E. coli expression system based on T7 promoter (pRSET-a) was used for T7 RNA polymerase recombinant protein expression. The T7 RNAP gene was amplified and ligated into a pRSET-an expression vector with a hexa-histidine tag at the N-terminus. The ligated vector was effectively transformed into E. coli BL21 (DE3). For T7 RNAP recombinant protein overexpression, it was confirmed that T7 RNA polymerase gene could be induced with IPTG up to 1.0mM, when the OD600 of the culture broth reached 0.5-1.2. The recombinant T7 RNA polymerase was harvested from the whole cell lysate after three hours of induction at 18oC. T7 RNA polymerase recombinant protein was efficiently purified by one-step immobilized-metal affinity chromatography (IMAC) using Ni-NTA resins. SDS-PAGE and western blot analysis confirmed the identity of the purified T7 RNA polymerase recombinant protein in soluble fractions with purity in the range of 60%. T7 RNA polymerase recombinant protein expression can be achieved by considering specific factors and suitable conditions.
EVALUATING NANDINI RIVER WATER QUALITY: A SYSTEMATIC REVIEW OF PHYSICOCHEMICAL STUDIES
Authors: Dhande Bhagyashri S , Narkhede Rajendra S
Published: December 2023

The quality of water is described to be the condition of the water, which includes the three basic forms of physical, chemical, and biological notions. Salinity, turbidity, the amount of dissolved oxygen and carbon dioxide, and microorganisms, herbicides, and pesticides along with the presence of heavy metals edit reminds to have a direct effect on the water quality. Because the universal solvent is a major factor affecting the lives of the humongous population of people, recognition of the quality of water is significantly important. Due to the fact that the presence of contaminants in water can directly lead to health issues such as reproductive problems, different kinds of neurological disorders, and gastrointestinal diseases, it is of vehement importance to understand the water quality.  Nandini River flows through  the Nashik city of  Maharashtraand it is the tributary of the river Godavari which is  is a vital source of water for the people of the Nashik region.Travelling from the heart of Nashik the river Nandini is faced with several issues related to its degrading water quality. Hence, the study sheds light onto the quality of water of the Nandini river, in terms of Physicochemical Studies.
Incorporation of Cloud Computing Services During the Knowledge Management Life Cycle: An Amalgamated Framework
Authors: Alawneh Ali Ahmad
Published: December 2023

Knowledge has been utilized as a leverage by many businesses organization In the Era of Knowledge economy, as it is considered scarce, valuable and cognitive asset. Accordingly, managing that knowledge is considered a fundamental challenge for business managers to obtain the greatest value from it because of its profound impact on employees, business processes, and products,  as well as to give organizations a sustainable competitive advantage in light of the hyper competition between businesses.  This study aims to integrate cloud computing services within the life cycle of knowledge management, with the aim of benefiting from the cloud computing services model (IaaS, PaaS, SaaS) as a breaking-through technological infrastructure to support the four processes of knowledge management (discovery, capture, sharing, application). It is expected that the proposed framework will serve as a reference for employees in knowledge economy organizations to infuse cloud computing services within the processes of creating, possessing, transferring and applying knowledge, which will have a fundamental impact on management practices in the areas of planning, problem-solving, decision-making and policymaking.
A new species of Sesioctonus Viereck (Hymenoptera, Braconidae, Agathidinae) from Peru
Authors: Sulca Lidia
Published: December 2023

A new species of Sesioctonus (Braconidae: Agathidinae), Sesioctonus alvaradae sp. nov. from Peru, is described and illustrated. With the addition of this new species, Sesioctonus genus has 36 species.Publicación registrada en Zoobank/ZooBank article registered:LSIDurn:lsid:zoobank.org:pub:27DF6B6F-86FD-4E30-8D13-ED78ACFE0B3EActo nomenclatural/nomenclatural act:Sesioctonus alvaradae Sulca, 2023LSIDurn:lsid:zoobank.org:act:BF4457F1-FEEF-4A50-B51B-AEE728B368C9
A cinco siglos de la introducción de la paloma de Castilla (Columba livia Gmelin, 1789) en el Perú
Authors: Pulido Victor
Published: December 2023

La paloma de Castilla (Columba livia Gmelin, 1789) originaria de África y Eurasia se encuentra ampliamente distribuida en la mayor parte de Europa, Asia occidental, África y América. Columba livia fue introducida en el Perú por los españoles en el siglo XVI. Habita en zonas urbanas y rurales; en las últimas décadas su población ha crecido de manera exponencial alrededor del mundo; se considera que es una especie comensal del ser humano y en algunos casos en las ciudades que coloniza, causa daño a la infraestructura y constituye un riesgo en la salud pública. Si bien su origen es silvestre se comporta como una de las especies con mayor interacción con los humanos. El incremento de su población en las ciudades la ha convertido en una especie plaga. En esta revisión se describe el estado actual del conocimiento de las poblaciones de Columba livia, sus posibles efectos sobre la salud de la población humana, el ornato público y el análisis de su condición de especie exótica invasora, a cinco siglos de su introducción en el Perú.
Parásitos en un venado de cola blanca silvestre en Cajamarca, Perú
Authors: Murga-Moreno César A. , Ruiz-Pérez David , Rojas-Moncada Juan , Ortiz Pedro , Sánchez Lidia , Torrel-Pajares Severino , Lareschi Marcela
Published: December 2023

En el presente estudio se informa sobre los parásitos encontrados en un venado de cola blanca, Odocoileus virginianus peruvianus, capturado en el bosque seco del distrito de Paccha, provincia de Chota, departamento de Cajamarca. El Servicio Nacional Forestal y de Fauna Silvestre recuperó los parásitos de un espécimen macho adulto y las remitió al Centro de Investigación en Medicina Tropical de la Universidad Nacional de Cajamarca para la identificación taxonómica de helmintos y artrópodos, y análisis coproparasitológico. Se identificaron dos metacéstodos correspondientes a Cysticercus tenuicollis. En los análisis coproparasitológicos cualitativos se hallaron huevos de Nematodirus spp. en una carga de 10 por gramo de heces (h.p.g.) y 40 h.p.g. tipo Strongílidos que no pudieron diferenciarse por la baja carga en el coprocultivo. No se detectaron huevos de trematodos en la sedimentación. De ectoparásitos, se identificaron ocho garrapatas duras Rhipicephalus (Boophilus) microplus y cinco piojos chupadores Solenopotes binipilosus. Varios de los ejemplares fueron depositados en el Museo de Historia Natural de la Universidad Nacional Mayor de San Marcos, Lima. Los hallazgos representan el primer reporte formal de la garrapata común del ganado en esta subespecie de cérvido. Además, se registra por primera vez la presencia del piojo Solenopotes binipilosus en territorio peruano.
Optimizing Computational Performance with OpenMP Parallel Programming Techniques
Authors:   Kyiv National Taras Shevchenko University, Zosimov Vjacheslav V. , Bulgakova Oleksandra S ,   Kyiv National Taras Shevchenko University
Published: December 2023

The article presents a study of parallel computing, specifically comparing the performance of OpenMP in C++ and Python. Furthermore, the technologies of OpenMP and TPL (C++, C#) are contrasted. Performance indicators were established that showcase the advantages and disadvantages of each methodology. In addition to the numerical data, the research provides insights into the peculiarities of each parallel computing model, which can assist developers in choosing the right tool.
EXPRESSION PROFILE OF SOME MARKERS OF LEUKEMIC STEM CELLS IN ACUTE MYELOID LEUKEMIA
Authors:   R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of NAS of Ukraine, Kyiv, Ukraine, Shlapatska L.M. , Polishchuk A.S. ,   R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of NAS of Ukraine, Kyiv, Ukraine, Gluzman D.F. ,   R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of NAS of Ukraine, Kyiv, Ukraine
Published: December 2023

Summary. Aim: identification of a potential pool of leukemic stem cells based on the combined expression of CD34, CD38 and CD117 in different acute myeloid leukemia (AML) subtypes. Object and methods: the studies were conducted on samples of bone marrow aspirates from 54 patients with newly diagnosed and untreated AML. The profile of the expression of surface antigens on leukemic (blast) cells of AML patients was studied by flow cytometry. Results: differences were found in the number of CD34+CD38–, CD34+CD38+, CD34–CD117+ and CD34+CD117+ cells, which can be leukemic stem cells (LSCs), among patients with different AML subtypes. The median percentage of CD34+CD38– cells in M2 AML (3.9%) and M3 AML (2.5%) is significantly lower than in M1 AML (11.3%) and M5 AML (13.0%), while the content of CD34+CD38+ cells is most represented in M2 AML and M5 AML. The analysis of the combined expression of CD34 and CD117 shows that M3 AML is more characterized by the presence of a population of CD34–CD117+ cells, while M1 AML and M5 AML are characterized by CD34+CD117+ blasts. Conclusion: in all studied AML subtypes, compartments of malignantly transformed cells, that potentially may be LSCs have been identified and are determined by the combined expression of CD34, CD38 and CD117. These studies are promising, since the definition of LSCs is the foundation for effective targeted therapy in patients with AML.
ALGORITHM OF PREOPERATIVE EXAMINATION AND METHODS OF SURGICAL TREATMENT OF PATIENTS WITH LOCALIZED KIDNEY CANCER
Authors:   R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Dumanskiy Yu.V. , Molchanov R.M. ,   Dnipro State Medical University, Dnipro, Maltsev A.V. ,   Educational and Scientific Medical Center “University Clinic”, Kharkiv, Ukraine, Reshetniak S.O. ,   Educational and Scientific Medical Center “University Clinic”, Kharkiv, Ukraine
Published: December 2023

Summary. Aim: to improve the effectiveness of surgical treatment of patients with localized renal cell carcinoma by improving the assessment of the location of the tumor at the preoperative stage, a thorough study of the vascular anatomy of the kidney and its relation to the tumor, and performing more effective and functionally sparing organ-preserving surgery. Results: based on a multifactorial comparative analysis of the studied criteria that influenced the effectiveness of treatment of patients with localized renal cell carcinoma (RCC) (T1-2vN0M0) we developed an algorithm for preoperative examination and a method of surgical treatment of tumorous lesions of the kidney, which provides a clear understanding of the vascular anatomy of the kidney, taking into account the possible variability of the organ’s angioarchitecture; rational surgical access; close proximity to the area of surgical interest; no need for lateral mobilization of the colon, which is impossible with transabdominal access absence of intraoperative renal ischemia; minimal probability of positive surgical margins; reliable hemostasis; no probability of postoperative trocar circles; satisfactory postoperative cosmetic effect.
Intus legere
Authors: Espíndola de Lima Teixeira Patrícia
Published: December 2023

O artigo possui caráter descritivo e intenciona contribuir com as pesquisas na área teológica, expandindo as possibilidades dos métodos qualitativos. A palavra método provém do grego methodos, que significa seguir o caminho para se chegar a um fim. O termo indica uma investigação científica, delineada e sistematizada com objetivo de produzir novos conhecimentos, discutir e/ou se integrar àqueles já existentes. Percebe-se que, em pesquisas em nível stricto sensu, instrumentos de levantamento de dados por meio de estudos empíricos são frequentes no campo das Ciências Humanas, mas nem sempre comum no campo teológico. Dentre os potentes métodos qualitativos existentes, o artigo aborda a investigação fenomenológica em sua epistemologia e exemplifica o trabalho da autora em sua tese doutoral. A investigação descreve o método fenomenológico através da experiência intus legere – que indica a leitura desde dentro das vivências humanas –, explana o desenvolvimento de entrevistas narrativas e detalha a exploração e sistematização dos achados por meio da análise textual discursiva como coerentes com a atitude fenomenológica. O artigo apresenta como recurso de ferramenta digital, o software ATLAS.ti, que, na análise, serviu como um otimizador da pesquisa qualitativa. Conclui ressaltando que a complexidade da contemporaneidade teológica, revela-se abundante em possibilidades de elaborações científicas originais ao expandir em pesquisas empíricas às fundamentações teóricas, sobretudo com facilitadores tecnológicos digitais. Finaliza encorajando novos pesquisadores do campo teológico em desenvolver o ineditismo de suas autorias no curso da pesquisa qualitativa fenomenológica.
Palavras-chave: Pesquisa, Teologia, Método qualitativo, Fenomenologia.
Nicolau de Paris e a suficiência das categorias
Authors: Rebelo Correia Mário João Rosas
Published: December 2023

A lista de dez categorias apresentada por Aristóteles no capítulo 4 das Categorias gerou, desde cedo, sérios problemas aos intérpretes. Em primeiro lugar, não é claro qual o objetivo e o âmbito desta lista. Trata-se de uma tentativa de estabelecer os gêneros mais gerais de palavras, de coisas, de conceitos, de todos eles? Em segundo lugar, Aristóteles enumera as categorias, mas não apresenta qualquer justificação para o seu número e completude. Esta lacuna conduziu os intérpretes a forjar diversas tentativas de resolver estes dois problemas. Na escolástica medieval de língua latina, quer por razões didáticas, quer por razões teóricas, a receção destes problemas tomou a forma de uma discussão acerca de uma via divisiva ou sufficientia que demonstrasse a completude da lista aristotélica. Evidentemente, para que essa via divisiva seja consequente, é necessário antes estabelecer qual o âmbito da lista. É intenção do presente artigo apresentar um dos primeiros textos do século XIII no qual estes problemas são discutidos: Rationes super Praedicamenta Aristotelis de Nicolau de Paris (m. 1263), importante magister artium da Universidade de Paris no segundo quartel do século XIII, autor de uma das primeiras sufficientiae neste contexto escolástico, fonte imprescindível para compreender a origem e a evolução deste tipo de resposta ao problema da completude da lista de categorias.
Desumanização e a banalidade do mal
Authors: Delatorre Leite Leonardo , Leite de Moraes Gerson
Published: December 2023

O presente artigo apresenta como intuito primordial uma exposição acerca da temática da desumanização presente na literatura de testemunho de Primo Levi (1919-1987) e nas reflexões de Hannah Arendt (1906-1975), sobretudo em sua obra Eichmann em Jerusalém. A investigação acerca do fenômeno da desumanização no universo concentracionário nazista será realizada, primordialmente, a partir de sua relação com a tese da banalidade do mal, que aborda a impessoalização e a perda da consciência moral como integrantes do projeto totalitário de supressão da individualidade e da banalização da barbárie. Numa primeira análise, foi estabelecida uma breve ponderação sobre os principais aspectos do “mal banal” na perspectiva da narrativa histórica de Arendt e de que forma tais elementos dialogam com a despersonalização. Em seguida, a temática da desumanização foi analisada propriamente na literatura primoleviana. Por fim, foi traçado um paralelo entre os dois autores, atestando, de forma categórica, um vínculo direto entre o totalitarismo, a proliferação da banalidade do mal e a desumanização. Fundamentado sob a metodologia de abordagem dedutiva, o presente trabalho foi construído com a utilização de fontes bibliográficas.
Oakeshott e a gênese do racionalismo moderno
Authors: Ferreira Gabriel
Published: December 2023

O pensamento do filósofo britânico Michael Oakeshott é frequentemente recrutado no debate entre conservadorismo e posições progressistas, no qual algumas de suas distinções e explicitações são postas a serviço da crítica a determinados aspectos dessa última. Um de seus principais movimentos argumentativos consiste em apontar que posições políticas fundamentalmente revolucionárias pressupõem certa concepção de racionalidade que, por sua vez, estaria em desacordo com uma visão clássica acerca da faculdade intelectiva humana ao mesmo tempo em que privilegia tal concepção em relação a outras esferas da experiência humana. No entanto, embora usual, tal reconstrução não apenas não faz justiça aos objetivos e à argumentação de Oakeshott, como parece ignorar uma compreensão mais genuína do racionalismo nos séculos XVII e XVIII. Assim, o objetivo deste artigo é explorar a argumentação de Oakeshott tal qual exposta na seção III de seu Rationalism in Politics a fi m de, simultaneamente, precisar seus objetivos e colocá-los em perspectiva em relação à gênese histórico-temática do racionalismo.
Acute necrotizing pneumonia and pyofibrinothorax in an experiment
Authors:   Dnipro State Medical University, Ukraine, Halahan A.A. , Dihtiar V.A. ,   Dnipro State Medical University, Ukraine, Lukianenko D.M. ,   Dnipro State Medical University, Ukraine
Published: December 2023

Nowadays, the problem of diagnosis and treatment of purulent-destructive diseases of the bronchopulmonary system in children remains relevant, that is connected with a large number of pulmonary-pleural forms and complications of acute necrotizing pneumonia. Purpose - to establish the correlation of changes in lung tissue and the pleural cavity of a growing organism, depending on the causative agents of pneumonia, elucidation and study of the mechanisms of pyofibrothorax formation and development. Materials and methods. The characteristic features of histopathological tissue changes in the lung parenchyma and adjacent tissues have been analyzed (visceral and parietal pleura, adhesion formation sections) of 45 immature laboratory rats, divided into 5 groups: the control group (intact animals), the Group 2 - contaminated with Klebsiella pneumoniae, the Group 3 - Staphylococcus aureus, the Group 4 - Candida albicans and the Group 5 with mixed flora (Klebsiella pneumoniae+Staphylococcus aureus) adding fungal infection (Candida albicans). Results. It was proved that the formation of a massive pyofibrinothorax is enhanced by mixed flora with the addition of fungi, that is more pronounced in the fifth series (group) of the experiment. Taking into account the data obtained experimentally, we consider whether fungi are Lukianenkoobtained in cultures of patients’ flora, they should be classified as a risk group of fibrothorax formation. Conclusions. Morphological changes of tissues under the influence of the infectious agent reached their maximum on the ninth day of the experiment (p<0.05). The pattern of necrotizing pneumonia is more pronounced in the Group 5 of experimental animals, which morphologically manifests itself in a more massive inflammatory infiltration (mostly due to rod- and segmented-nuclear neutrophils), foci of destruction and abscessation of the lung parenchyma and has a direct association with the polymicrobial etiology of the disease (Klebsiella pneumoniae+Staphylococcus /taureus+Candida albicans) (p<0.05). The formation of a massive pyofibrinothorax is enhanced by mixed flora, especially with the addition of fungi. The study was carried out in accordance with the principles of the European Convention for the Protection of Vertebrate Animals used for Experimental and Other Scientific Purposes, as well as the law of Ukraine. The research protocol was approved by the Local Ethics Committee of the institution mentioned in the article. No conflict of interests was declared by the authors.
Single Functional Index Quantile Regression for Functional Data with Missing Data at Random
Authors: Kadiri Nadia , Mekki Sanaà Dounya , Rabhi Abbes
Published: December 2023

The primary goal of this research was to estimate the quantile of a conditional distribution using a semi-parametric approach in the presence of randomly missing data, where the predictor variable belongs to a semi-metric space. The authors assumed a single index structure to link the explanatory and response variable. First, a kernel estimator was proposed for the conditional distribution function, assuming that the data were selected from a stationary process with missing data at random (MAR). By imposing certain general conditions, the study established the model’s uniform almost complete consistencies with convergence rates.
Evaluation of the Labour Market Situation of Young People in EU Countries – The Multiple Regression Approach
Authors: Kawecka Magdalena
Published: December 2023

The article considers the problems of young people aged 20-24 on the labour market affected by unemployment in European Union countries. Unemployment is one of the most important economic and social problems, which at the same time constitutes one of the biggest measures characterising the condition of the economy. The diversity of the economic situation in EU countries directly affects young people, an individual group of people entering the labour market and have little or no professional experience. At the same time, they are ready to start work, facing great difficulties in entering the market, influenced by socio-economic as well as demographic factors which directly and indirectly affect employment. Considering the above premise, the aim of the article was to identify the determinants of unemployment of young people aged 20-24 in the EU. The study used data from two years: 2010 and 2020, and applied multiple regression. Statistical data were taken from Eurostat databases. The study allowed to examine the dependence of the influence of individual socioeconomic as well as demographic factors on youth unemployment. The study found that the multivariate regression showed that factors related to young people's participation in education and training (including the NEET rate) relative to labour market status, as well as social inclusion, had a significant impact on the unemployment studied. Over the decade, a decrease was seen in unemployment in most EU member states, in as many as 19 countries, while the remaining eight countries showed an increase.
Nowa wersja motu proprio „Vos estis lux mundi”. Znaczenie zmian wprowadzonych przez papieża Franciszka w 2023 roku
Authors: Dohnalik Jan
Published: December 2023

Niniejszy artykuł dotyczy nowej wersji listu mu proprio Vos estis lux mundi, ogłoszonej przez papieża Franciszka 25 marca 2023 roku. W porównaniu z wersją ad experimentum z 2019 roku obecny dokument zawiera pewne zmiany, które są przedmiotem niniejszego studium. Artykuł 1 zawiera nowe sformułowanie poszczególnych kategorii osób skrzywdzonych wykorzystaniem seksualnym. Oprócz kategorii małoletniego dodano dwie kolejne: osobę, która ma niepełne używanie rozumu, oraz bezbronnego dorosłego. W odniesieniu do pornografii wprowadzono również kilka istotnych zmian mających na celu lepszą ochronę małoletnich i bezbronnych dorosłych. Zgodnie z art. 2 diecezje „muszą zapewnić instytucje lub biura, które są łatwo dostępne dla każdego w celu składania zawiadomień”. W tym samym artykule rozstrzygnięto kontrowersję dotyczącą jurysdykcji przełożonych kościelnych w tych sprawach. O ile nie zostanie to wzajemnie uzgodnione, „odpowiedzialność ponosi ordynariusz miejsca, w którym miały miejsce zdarzenia”. W art. 3 potwierdzono obowiązek denuncjacji, z wyjątkiem przypadków uzyskania informacji na forum wewnętrznym. Zgodnie z art. 4 obowiązek milczenia nie może być nałożony na osobę zgłaszającą, jak również na osobę, która twierdzi, że jest skrzywdzona i świadków. Istotną nowością dokumentu jest podjęcie kwestii przestępstw i zaniedbań ważnej grupy przełożonych: „wiernych świeckich, którzy są lub byli moderatorami międzynarodowych stowarzyszeń wiernych” (art. 6). Dlatego też lista kompetentnych dykasterii została rozszerzona w art. 7 o Dykasterię ds. Świeckich, Rodziny i Życia. Ponadto podkreślono rolę Dykasterii ds. Instytutów Życia Konsekrowanego i Stowarzyszeń Życia Apostolskiego poprzez dodanie nowego art. 10. W całym dokumencie szczególną uwagę zwraca się na prawną ochronę dobrego imienia wszystkich zaangażowanych osób. Mogło to być powodem dodania nowego przepisu w art. 18: „Kopia akt ma być przechowywana w archiwum kompetentnego przedstawiciela papieskiego”. Najważniejsza zmiana to ta, że nowy Vos estis lux mundi jest teraz stabilnym prawem, które ma być stosowane w harmonii z innymi ustawami Kościoła.
Sakrament małżeństwa w dziewiętnastej księdze Dekretu biskupa Burcharda z Wormacji
Authors: Story Marek
Published: December 2023

Księgi pokutne, które powstały w epoce późnej starożytności chrześcijańskiej i wczesnego średniowiecza, są świadectwem kształtowania się praktyki pokutnej w Kościele. Celem artykułu jest ukazanie w świetle dziewiętnastej księgi Dekretu biskupa wormackiego Burcharda niewłaściwych zachowań godzących w sakrament małżeństwa, które powodowały obciążenie winnych dotkliwymi karami – pokutami wymagającymi odpowiedniego zadośćuczynienia, często trudnego do realizacji. Biskup z Wormacji, dostrzegając szerzący się upadek obyczajów w kwestii wierności małżeńskiej, zobowiązał spowiedników, aby w czasie spowiedzi zwracali uwagę na sprawę nierozerwalności małżeństwa – zdarzały się bowiem przypadki wielożeństwa, czy nawet małżonkobójstwa w celu zawarcia nowego związku. Duszpasterze mieli także dążyć do tego, by poprzez pokutę wyeliminować niewłaściwe zachowania seksualne penitentów z członkami rodzin (współżycie ze szwagierką lub macochą), czy też namawianie współmałżonka do zdrady. W czasie sprawowania sakramentu pokuty odnoszono się ponadto do zagadnień związanych z przeszkodami do zawarcia małżeństwa, do których zaliczano chociażby przeszkodę pokrewieństwa, powinowactwa, czy też uprowadzenia kobiety w celu zawarcia z nią związku małżeńskiego oraz podkreślano znaczenie zaręczyn jako ważnego etapu do zawarcia małżeństwa.
Depozyt wiary jako kryterium prawdziwości nauki Kościoła
Authors: Szczurek Jan Daniel
Published: December 2023

We współczesnej teologii pojęcie depozytu wiary jest rzadko wykorzysty­wane. Celem artykułu jest wykazanie jego doniosłości w zachowaniu inte­gralności przekazu apostolskiej wiary Kościoła. Pojęcie depozytu jest istotne ze względu na ciągłość i tożsamość nauczania apostolskiego, przyjętego od Chrys­tusa i przekazanego Kościołowi. Pozwala bowiem dokładniej określić granice pluralizmu teologicznego. W rozwoju teologii jest wiązane z apologetyką, a jej renesans sprzyja pogłębionym studiom nad jego znaczeniem dla wykazywania apostolskiego charakteru współczesnego nauczania Kościoła.Istotnym elementem tego pojęcia jest zaufanie okazywane przez depo­nenta (Chrystusa) depozytariuszowi (Kościołowi), które zobowiązuje do zacho­wania depozytu w stanie nienaruszonym. Stąd wynika wielka odpowiedzialność całego Kościoła i każdego katolika jako depozytariusza. Depozyt wiary rozumiany jako „suma dóbr zbawczych” (suma treści noetycz­nych i ontycznych) ma charakter sakralny w dwojakim znaczeniu: jest darem objawiającego się Boga i jest przechowywany w świątyni, którą jest każdy wierzący w Chrystusa. Sta­nowi rezerwuar niezmiennych dogmatów i „miejsce” do poszukiwania odpowiedzi na coraz to bardziej dociekliwe pytania wynikające ze zmieniających się nieu­stannie uwarunkowań życia człowieka. Depozyt wiary jest tą rzeczywistością, która może skutecznie pomóc w walce ze współczesnym kryzysem wiary i moralności katolickiej, a nawet tożsamości samego Kościoła.
Pensjonariusze parafii szpitalnych diecezji krakowskiej w wizytacji bp. Kajetana Sołtyka (1781–1785). „W potrzebach życia opatrzenie, a do zbawienia duszy przewodnictwo”
Authors: Chromy Dariusz
Published: December 2023

W polskiej części diecezji krakowskiej funkcjonowało 50 parafii szpitalnych. Każda z nich miała swojego proboszcza, swój kościół i uposażenie. Integralną częścią każdej fundacji był szpital i zamieszkujący go ubodzy. Pod koniec XVIII wieku było ich około 200. Kilkudziesięciu spośród nich możemy poznać z imienia i nazwiska. W przypadku kilkunastu znamy miejsce pochodzenia, wiek i stan. Życie pensjonariuszy miało swój rytm. Wyznaczała go codzienna modlitwa wyuczona przez prepozyta, praca ręczna i chodzenie po jałmużnie.