bluuebunny/crossref_metadata_2025 huggingface dataset:
Transnational Sunni Pesantren and Their Socio-Political Engagement in Contemporary Indonesia
Authors: Muhammad Hasyim , Sobirin Mohamad , Zuhri Mishbah Khoiruddin , Masruri Ulin Niam
Published: December 2024

The main paradigm in Sunni political theology is harmony and stability. This thinking is based on the background and tendencies of Sunni figures in the state political issues they faced at their time. Islamic boarding schools in Indonesia generally adhere to Sunni theology, including political paradigms and attitudes. Therefore, they have high attention and participation in national politics in Indonesia. Because for them, attention to and participation in national politics is an expression of the belief that love for the motherland is part of faith. In this context, new Islamic boarding schools with Sunni theology have emerged in different forms from the long-existing Sunni Islamic boarding schools. These new Islamic boarding schools have a network with the world outside and it is assumed that their establishment cannot be separated from the context of transnational Islam. Our question is, are they Educating for or Against National Political Ignorance in the midst of currents of democratization and mainstreaming of nationalism in contemporary Indonesia? The objects of this research are three transnational pesantren with Sunni theology with different international networks, namely one with a network of Saudi Arabia, one with a network of Syrian Lebanon, and one with a network of Turkey. The primary sources of this research are the results of interviews with authoritative parties in the three institutions, observations of the pesantren environment, and documentation from pesantren brochures and related documents. We found that (1) this transnational pesantren with Sunni theology only focuses on teaching Islamic education as is the case with traditional Islamic boarding schools (salafiyah), only validating the truth of their Islamic knowledge, equally pivoting on the main figure who is the reference for their knowledge, namely Sayyid Muhammad bin Alawiy Al Maliki (Haromain-Rusyaifah Islamic Boarding School), Sheikh Abdullah Al-Harariy (Shahamah-Lebanon Islamic Boarding School), and Sheikh Sulaiman Hilmi Tunahan (Sulaimaniyah Islamic Boarding School-Turkey). The three figures have written works which are made part of the compulsory curriculum for every student at the pesantren. (2) The socio-religious movement of the Lebanese Islamic Boarding Schools (Syahamah) in Indonesia is framed in the ASWAJA movement which is in line with the idea of ​​a nation-state, although in fact, their concern is more in the theological movement in the form of the conservation of the ASWAJA monotheism doctrine. As for the organizational movement of the Makah Islamic Boarding School (As-Sofwah or Haromain) it looks affirmative towards issues that link religion and the state. Meanwhile, the overall picture of the religious social movement carried out by the Turkish Islamic Boarding Schools in Indonesia shows a passive and even apathetic attitude towards the issue of Indonesian national politics.
The essence and practical application of state financial control mechanisms in Ukraine
Authors: Popovych Serhii
Published: December 2024

The article examines the issue of state financial control, audit, its mechanisms in the present. An aim is to reveal the essence of state financial control mechanisms and their practical application in modern Ukraine. Results. The essence of the mechanisms of the formation and development of state audit as a complex state-management and socio-economic education, which includes the identified and integrated five components of the main mechanisms (social-economic, organizational-legal, information-communication, personnel, research), which allows implement the functions of state financial control with an impact on efficiency and effectiveness, as well as its accountability to society and the state.
This article delves into the subject of state financial control and audit, exploring their mechanisms in the contemporary context. The primary objective is to unveil the essence of state financial control mechanisms and their practical implementation in present-day Ukraine.
The study reveals that state audit functions as a multifaceted state-management and socioeconomic discipline, comprising five integrated components of the main mechanisms. These components encompass social-economic, organizational-legal, information-communication, personnel, and research aspects, enabling the execution of state financial control functions with a focus on enhancing efficiency, effectiveness, and accountability to both society and the state.
Differences in foreign experience in the field of public procurement
Authors: Serzhuk Anastasiia
Published: December 2024

The article considers the concept and significance of public procurement, the current state in the Ukrainian market, achievements in recent years and comparison with other countries. The main legislative acts regulating the activities of public procurement are considered. Aspects of the functioning of the e-procurement system in Ukraine are highlighted. The dynamics of public procurement in Ukraine in recent years is analyzed.
Regulation of public procurement in the EU countries has become more specific, gradual and systematic in recent years. Additional developments have taken place to open up national public procurement markets and attract a wider range of potential suppliers.
Leveraging Big Data through NoSQL Databases-Architecture Methodologies, and Strategic Applications
Authors:   Flynas, Saudi Arabia, Siddiqui Muhammad Rawish
Published: December 2024

The rise of Big Data has necessitated the evolution of databases beyond traditional relational models, paving the way for NoSQL
databases to manage unstructured and semi-structured data at scale. This paper explores the architecture, methodologies, and
strategic applications of NoSQL databases in the Big Data ecosystem. We will examine key challenges, tools, and technologies
supporting NoSQL adoption and discuss real-world use cases across industries. Additionally, we will outline general activation
steps, dependencies, and the risks associated with deploying NoSQL databases in enterprise settings.
Pengaruh Event Activity Terhadap Kepuasan Pengunjung Pada Acara Olahraga
Authors: Susanti Putri Aprilia Widi , Farrah Farrah , Heykal Muhammad
Published: December 2024

Event activity selalu menjadi daya tarik tersendiri bagi para pengunjung yang akan dan hadir pada event tersebut. Kegiatan – kegiatan yang menarik dapat memenuhi harapan pengunjung dan membuat mereka merasa puas. Dalam penelitian ini akan terlihat seberapa berpengaruhnya event activity yang menarik dan unik kepada kepuasan pengunjung yang telah mengikuti sebuah acara khususnya acara olahraga. Kepuasan pengunjung menjadi tolak ukur keberhasilan sebuah event apabila pengunjung merasa harapannya terpenuhi maka dapat dipastikan event itu berhasil memenuhi harapan pengunjung melalui seluruh aspek pada event tersebut. Dalam penelitian ini penulis menggunakan metode analisis deskriptif dengan menggunakan metode pengambilan data melalui penyebaran angket atau kuesioner kepada para responden. Hal ini dilakukan guna mengetahui bagaimana feedback responden terhadap kegiatan pada event Karnaval Sehat Aqua. Dari hasil data angket atau kuesioner yang sudah diolah oleh penulis diketahui bahwa event activity berpengaruh terhadap kepuasan pengunjung yang mengikuti kegiatan pada event Karnaval Sehat Aqua.
Pengaruh Kualitas Produk, Kualitas Pelayanan, Dan Personal Selling Terhadap Keputusan Pembelian Konsumen Pada PT. Indako Trading Coy Medan
Authors: Wijaya Louis Fernando , Chandra Albert Giovanni , Nainggolan Tuty , Berlien Richard
Published: December 2024

Honda didistribusikan ke berbagai daerah di Indonesia, termasuk kota Medan, oleh PT. Indako Trading Coy Medan. Meskipun Honda adalah merek motor yang sangat terkenal, perusahaan ini masih bisa mengalami peningkatan penjualan. Namun, dalam beberapa tahun terakhir, PT. Indako Trading Coy Medan mengalami penurunan penjualan. Konsumen yang semakin selektif dalam memilih produk melakukan berbagai evaluasi dan membandingkan merek Honda dengan pesaing seperti Yamaha, kemudian memilih produk yang paling unggul dan memberikan banyak manfaat bagi mereka. Oleh karena itu, penurunan keputusan pembelian ini dikaitkan dengan pengaruh kualitas produk, kualitas pelayanan, dan personal selling. Tujuan penelitian ini adalah untuk mengetahui dan menganalisis pengaruh kualitas produk, kualitas pelayanan, personal selling terhadap keputusan pembelian konsumen pada PT. Indako Trading Coy. Penelitian ini melibatkan 10.617 konsumen yang membeli produk dari perusahaan selama periode 2020 hingga 2022. Teknik penentuan sampel menggunakan rumus Slovin dengan tingkat toleransi 10%, sehingga diperoleh sebanyak 99 sampel. Hasil penelitian menunjukkan bahwa kualitas Produk berpengaruh positif dan signifikan terhadap Keputusan Pembelian konsumen pada PT. Indako Trading Coy. Kualitas Pelayanan berpengaruh positif dan signifikan terhadap Keputusan Pembelian konsumen pada PT. Indako Trading Coy. Personal Selling berpengaruh positif dan signifikan terhadap Keputusan Pembelian konsumen pada PT. Indako Trading Coy. Secara serempak Kualitas Produk, Kualitas Pelayanan dan Personal Selling berpengaruh signifikan terhadap Keputusan Pembelian konsumen pada PT. Indako Trading Coy.
Pengaruh Kualitas Sumber Daya Manusia Terhadap Peningkatan Pelayanan Di Kelurahan Mustikasari Kota Bekasi
Authors: Yuni T Veronika , Marthalia Lia , Dewi Ratna Kusuma
Published: December 2024

This study aims to lookat performance and governance in the implementation of servise activities to public, and also relationships with leaders and fellow employees. Improving the quality of servise, must always pay attention to the demands and dynamics of the people who are in an atmosphere must pay attention to the demandsand dynamic of people who are in an atmosphere of Europhoria reform, democracy, democratization, decentralization, regional autonomy and human rights enforcement, intended to anticipate the advancement of scienceand technology. Therefore, improving the quality of service is a continuous, on going effort and is carried out by all government officials in the City of Bekasi
Sistem Pakar Diagnostik Penyakit Pohon Aren dengan Pendekatan Certainty Factor
Authors: Putri Nadya Andhika , Siregar Maimunah , Perwitasari Ika Devi , Mayasari Siska
Published: December 2024

Pohon aren (Arenga pinnata) merupakan salah satu tanaman penting dalam sektor pertanian yang memiliki nilai ekonomi tinggi di berbagai wilayah. Namun, produksi dan kualitas pohon aren sering kali terganggu oleh serangan penyakit. Proses identifikasi dan diagnosis penyakit pada pohon aren memerlukan keahlian khusus yang seringkali tidak dimiliki oleh semua petani atau tenaga ahli di lapangan. Oleh karena itu, sistem pakar berbasis teknologi dapat menjadi solusi efektif dalam memberikan diagnosis awal serta rekomendasi pengendalian penyakit.Penelitian ini bertujuan untuk mengembangkan sistem pakar diagnostik penyakit pada pohon aren menggunakan metode certainty factor (CF). Metode CF dipilih karena mampu mengukur derajat kepastian dalam penentuan diagnosis berdasarkan gejala yang teramati, sehingga menghasilkan output diagnosis yang lebih akurat dan sesuai dengan kondisi nyata di lapangan. Sistem pakar ini dirancang untuk menganalisis berbagai gejala yang diinput pengguna dan memberikan kemungkinan jenis penyakit serta tingkat keparahan berdasarkan nilai CF yang dihitung dari aturan dan bobot kepercayaan pakar.Hasil pengujian menunjukkan bahwa sistem pakar ini mampu mengidentifikasi jenis penyakit pohon aren dengan tingkat akurasi yang baik, serta memberikan kemudahan bagi pengguna dalam mengakses informasi terkait gejala dan solusi pengendalian penyakit. Diharapkan, sistem pakar ini dapat membantu petani dan penyuluh pertanian dalam melakukan diagnosis dini, sehingga langkah-langkah pencegahan dan penanganan penyakit dapat diterapkan dengan lebih tepat.
Pendekatan UML dalam Desain Sistem Informasi Rantai Pasok untuk Optimalisasi Produk Pertanian di Pertumbukan Wampu
Authors: Hendrawan Jodi , Perwitasari Ika Devi , Wibowo Fachrina , Fahriansyah Fahriansyah
Published: December 2024

Penelitian ini bertujuan untuk merancang sistem informasi rantai pasok produk pertanian di Pertumbukan Wampu dengan menggunakan pendekatan Unified Modeling Language (UML). Sistem ini dirancang untuk meningkatkan efisiensi operasional, transparansi data, dan pemantauan kinerja dalam proses distribusi produk pertanian. Desain sistem meliputi penggunaan berbagai diagram UML seperti Use Case, Class, Activity, Sequence, dan Component yang menggambarkan alur dan interaksi antar aktor dalam rantai pasok. Untuk memastikan kelayakan dan relevansi desain, sistem ini divalidasi melalui dua metode utama, yaitu expert review dan user acceptance testing (UAT). Hasil validasi menunjukkan bahwa desain sistem telah memenuhi kebutuhan pengguna dan ekspektasi operasional. Sistem memungkinkan pelacakan stok secara real-time, meningkatkan transparansi antara petani, distributor, dan pengecer, serta menyediakan fitur pemantauan kinerja untuk analisis lebih lanjut. Berdasarkan hasil penelitian, dapat disimpulkan bahwa pendekatan UML efektif dalam merancang sistem informasi yang kompleks dan dapat diimplementasikan untuk mengoptimalkan proses rantai pasok produk pertanian di Pertumbukan Wampu.
Aristoteles’in Politika Felsefesi ve Günümüz: Adalet, Erdem ve İyi Yaşamın İzleri
Authors: Küçük Semiha
Published: December 2024

Politik bir varlık olarak insana dair özsel meselelerin temelinde yer alan adalet kavramı, yüzyıllar boyunca tartışmalara neden olmuştur. Bu tartışmalar sınırlı bir çerçeveden normatif düzeyde uyuşmazlıkları çözmek adına yapılmış görünse de asıl mesele hangi dönem ve hangi koşul olursa olsun, insanın ‘adil olan’ ihtiyacından kaynaklanmaktadır. Nitekim makul insanlar dahi neyin adil olduğu konusunda sıklıkla anlaşmazlığa düşmektedirler. Özellikle modern dönemden itibaren adalete ilişkin iddiaların çoğu, yurttaşların eşitlik ve özgürlük kavramları temelinde, hakların nasıl tanımlanacağı ve refahın nasıl dağıtılacağı üzerine yoğunlaşmıştır. Bu minvalde, toplumun doğru örgütlenmesine karar verirken ihtiyaç duyulan şey genel ilkeler ve teorik akıl yürütmeler olmuş, adalet üzerine düşünceler de çeşitli teorilerde somutlaştırılmaya çalışılmıştır. Ancak günümüze yaklaştıkça artan sosyal ve kültürel karmaşıklık, tek bir adalet doktrini arayışı çabalarını da geçersiz kılmıştır. Özellikle modern dönemden itibaren etkin olan liberal anlayış, rasyonel olanın bu düzende cisimleştiğine bireylerini inandırmış, bu inanış insanın adalet üzerine sorgulama yapmak yerine ‘adaletsizlik hissi’nde yaşam sürmesine neden olmuştur. Bu hissin en önemli nedenlerinden biri Aristoteles’in vurguladığı ‘insan politik bir canlıdır’ görüşü ve politikanın konusunun insan için neyin iyi olduğuna dair bir arayış olduğunun unutulmuş olmasından kaynaklanmaktadır. Bunun yanı sıra Aristoteles’te iyi’nin yalnızca insan için değil aynı zamanda polis için de bir hedef olması, adaletin toplumsal iyi olması noktasında önem arz eder. Bu mesele hem toplumdan hem etik-politik meselelerden uzaklaşan bireyi ve bu uzaklaşmanın nedenlerini, ayrıca yaşanan ‘adaletsizlik hissi’ni düşünmek noktasında çalışmamıza ışık tutacaktır. Bu çalışmanın amacı, Antik Dönem’deki ‘ortak iyi’ anlayışı temelinde Aristoteles’in politika felsefesi açısından adalet kavramını anlamaya çalışmak ve özellikle adaleti bütünleyen erdem ve iyi yaşam kavramlarının günümüzde nasıl kavrandığını değerlendirmek olacaktır.
Dynamics of iron and manganese content in the surface waters of Gelendzhik and Blue bays in 2023
Authors: Fedorova Polina A. , Chasovnikov Valeriy K. , Fedorov Alexey V.
Published: December 2024

In this work, the dynamics of iron and manganese content in the surface layer of Gelendzhik and Blue Bays during 2023 was studied. Several exceedances of the MPC levels of iron and manganese were detected in both studied waters. High concentrations of iron and manganese are associated with strong winds and storm events, or with increased precipitation and large coastal runoff recorded on the eve of sampling.
Gambaran Identitas Diri Dan Kecemasan Sosial Remaja
Authors: Wisanti Eka Rizqy , Yovinna T. Vella , Apriliani Reka
Published: December 2024

Remaja membutuhkan perhatian khusus terkait tumbuh kembang untuk menangani masalah-masalah kesehatan baik fisiologis maupun psikologis. Pembentukan identitas diri remaja memiliki masalah terhadap tantangan perkembangan yang cenderung mengalami krisis dalam pembentukan identits diri yang berbeda dari setiap remaja. Hal ini juga sama dengan masalah kecemasan sosial pada remaja yang dapat terjadi karena setiap remaja cenderung mengalami kecemasan, akan tetapi tingkat kecemasan sosial setiap remaja berbeda. Tujuan penelitian ini mengidentifikasi gambaran karakteristik responden dan gambaran identitas diri remaja serta kecemasan sosial remaja. Penelitian ini merupakan penelitian kuantitatif yang menggunakan desain deskriptif analisis dan teknik sampling consecutive sampling dengan populasi di SMP Negeri 1 Pekanbaru dan sampel sebanyak 207 orang. Analisis yang digunakan ialah analisis univariat variabel identitas diri remaja dan kecemasan sosial remaja. Hasil penelitian menunjukkan mayoritas responden memiliki identitas diri dengan kategori tinggi yaitu sebesar (67,1%) dan kecemasan sosial berada pada kategori sangat tinggi (32,9%). Diharapkan bagi pihak sekolah dapat memberikan bimbingan untuk mengontrol kecemasan sosial serta program konseling agar menimalisir kecemasan sosial remaja
Evaluating the impact of cell-penetrating motif position on the cellular uptake of magnetite nanoparticles
Authors: Salgado Laura , Cifuentes-Delgado Paula C. , Orozco Juan Camilo , Muñoz-Camargo Carolina , Reyes Luis H. , Quezada Valentina , Cruz Juan C.
Published: December 2024

Cell-penetrating peptides (CPPs) have been employed to enhance the cellular uptake and intracellular delivery of various nanocarriers. Among them, nanoparticles (NPs) have been used as suitable vehicles for delivering different bioactive molecules in the treatment of a diverse range of diseases. Given the pivotal role of the conjugation method of CPPs, this study aims to evaluate the impact of the position of a cell-penetrating motif (LFVCR) on the biocompatibility, cellular uptake, and endosomal escape of magnetite NPs. The designed peptide’s physicochemical properties suggest they are well-suited for efficient cell penetration with minimal cytotoxicity. The resulting designed nanoconjugates were characterized using Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), dynamic light scattering (DLS), and transmission electron microscopy (TEM). The results indicate that motif position significantly impacts the cellular uptake and endosomal escape of the designed nanobioconjugates. Key findings suggest that motif exposure enhances endocytosis-mediated cell internalization and improves endosomal escape efficiency. These results were compared with nanobioconjugates displaying previously reported CPPs. The selected nanobioconjugate demonstrated superior performance in endosomal escape and comparable cell uptake to the reference nanobioconjugates. These results, along with the nanobioconjugate’s physicochemical characteristics and high biocompatibility, position the nanocarrier as a suitable candidate for delivering diverse bioactive molecules.
Detection of PD-L1 expression levels in malignant pleural mesothelioma with a targeted MRI nanoprobe in vivo
Authors: Zhang Zhenghua , Tian Yang , Gao Wenjun , Hu Yubin , Luo Liangping , Lei Lichang , Shen Shasha , Han Dan
Published: December 2024

Objectives

Immune checkpoint inhibitors (ICIs) have demonstrated potential in inhibiting the growth of malignant pleural mesothelioma (MPM), and their efficacy is associated with the expression of programmed death-ligand 1(PD-L1). This study evaluated a PD-L1-targeted nanoprobe for detecting PD-L1 expression in a nude mouse model of malignant pleural mesothelioma (MPM).

Methods

A PD-L1-binding peptide (WL-12) was conjugated with superparamagnetic iron oxide nanoparticles (SPIONs) to create the nanoprobe WL-12@Fe₃O₄. The nanoprobe’s stability, biotoxicity, targeting ability, and in vivo magnetic resonance (MR) imaging effects were assessed and compared to non-targeted Fe₃O₄ nanoparticles. ΔT2 values and PD-L1 expression were measured in H226 and MSTO-211H tumor tissues over 4 weeks to analyze correlations.

Results

The WL-12@Fe₃O₄ nanoprobe demonstrated uniform distribution and a spherical shape, with a larger size (43.82 nm) and lower surface potential (−9.34 ± 0.54 mV) compared to Fe₃O₄ (32.67 nm, −20.20 ± 0.88 mV, P < 0.05). The XPS and FT-IR analysis results indicate the successful coupling of WL-12 with Fe3O4. It was well dispersed in serum and saline and showed no cytotoxicity or organ damage in vivo. The probe selectively accumulated in PD-L1-expressing MPM cells, especially MSTO-211H, and exhibited significantly higher uptake in high PD-L1-expressing H460 cells (930.22 ± 11.75 ng/mL) compared to low PD-L1-expressing A549 cells (254.89 ± 17.33 ng/mL, P < 0.05). Tumor iron levels in the WL-12@Fe₃O₄ group were significantly elevated (141.02 ± 17.33 μg/g) compared to controls (36.43 ± 3.56 μg/g, P < 0.05), with no significant differences in other organs (P > 0.05). The T2 values of H226 and MSTO-211H tumors decreased after probe injection, with ΔT2 values significantly higher in the targeted group than the nontargeted group (P < 0.05). ΔT2 values increased over 4 weeks, correlating strongly with PD-L1 expression (P < 0.05).

Conclusion

The PD-L1-targeted nanoprobe with MRI is a promising tool for noninvasive, real-time assessment of PD-L1 expression in MPM.
The function of miRNAs in the immune system's inflammatory reaction to heart failure
Authors: Yibulayin Kadierya , Abulizi Maidinaimu
Published: December 2024

Heart failure is the end stage of cardiovascular disease, with high morbidity and mortality rates worldwide. Heart failure is associated with long-term and insufficient inhibition of inflammatory response. miRNA is a class of endogenous, non-coding, single-stranded small RNA molecules, that can regulate gene expression through translational inhibition or degradation of targeted mRNA, widely regulate myocardial remodeling, inflammatory response, and other pathological processes, and play an important regulatory role in the occurrence and development of cardiovascular diseases. This article reviews the role of miRNA in the inflammatory response in heart failure.
Effects of single-tree selective harvest method on ecosystem services in a mixed temperate broadleaf forest in Iran
Authors: Karamdoost Marian B. , Alijanpour A. , Banj Shafiei A. , Sasanifar S. , Álvarez-Álvarez P.
Published: December 2024

Introduction

This study examines the effects of the single-tree selective harvesting method on ecosystem services in a mixed temperate broadleaf forest in Iran. Key indicators such as carbon sequestration, tree species diversity, soil nutrient cycling, and stand volume are analyzed, emphasizing their significance for sustainable forest management.

Methods

The research was conducted in four districts, each comprising two parcels: one managed using the single-tree selective harvesting method and the other serving as a control. Data on ecological and biodiversity parameters were collected, and statistical analyses, including two-way ANOVA and Principal Component Analysis (PCA), were performed to assess the impact of management practices.

Results

The findings reveal that the single-tree selective harvesting method significantly influences regulating and supporting ecosystem services. Carbon storage varied with elevation, affecting both soil and forest floor litter. Tree species diversity increased, with more species present and a reduction in dominance by certain species. However, this method also resulted in reduced stand volume in the managed areas. Elevation significantly impacted diversity indices, litter carbon storage, available potassium, and stand volume. Additionally, the interaction between management and elevation was significant for soil carbon storage, richness, diversity, total nitrogen, available potassium, and stand volume.

Discussion

The single-tree selective harvesting method appears to be a viable forest management strategy for preserving ecosystem services in mixed temperate broadleaf forests, maintaining ecosystem health without significant negative effects on soil. However, careful consideration of site-specific ecological conditions and trade-offs between provisioning and regulating services is crucial. These findings have important implications for sustainable forest management in Iran and similar forest ecosystems globally.
Bidirectional association between rheumatoid arthritis and chronic obstructive pulmonary disease: a systematic review and meta-analysis
Authors: Wang Meijiao , Pan Hejing , Zhai Yingqi , Li Haichang , Huang Lin , Xie Zhijun , Wen Chengping , Li Xuanlin
Published: December 2024

Background

Rheumatoid arthritis (RA) and chronic obstructive pulmonary disease (COPD) are prevalent and incapacitating conditions, sharing common pathogenic pathways such as tobacco use and pulmonary inflammation. The influence of respiratory conditions including COPD on RA has been observed, meanwhile RA may constituting one of the risk factors for COPD. It unclear that whether a bidirectional associate between RA and COPD. Our study aims to explore the bidirectional relationship between RA and COPD.

Methods

We systematically searched PubMed, Cochrane Library, and Embase for observational studies from the databases inception to February 20, 2024, utilizing medical subject headings (MeSH) and keywords. We included studies in which RA and COPD were studied as either exposure or outcome variables. Statistical analyses were conducted employing STATA software (version 14.0). The relationship was reported as odds ratios (OR) and corresponding 95% confidence intervals (CI). Publication bias was assessed using funnel plots and Egger’s regression.

Results

Nineteen studies with 1,549,181 participants were included. Risk of bias varied from low to moderate, with evidence levels rated as low or very low. Pooled analysis revealed a significant association between RA and increased COPD risk (OR=1.41, 95%CI 1.13 to 1.76, I2 = 97.8%, P=0.003). Subgroup analyses showed similar COPD risk elevations in both of genders, seropositive/seronegative RA, cohort and case control studies. Additionally, there was a significant RA risk increase among those with COPD (OR=1.36, 95%CI 1.05 to 1.76, I2 = 55.0%, P=0.022), particularly among females and seropositive RA, and cohort studies.

Conclusion

The meta-analysis identifies a significant bidirectional association between RA and COPD, emphasizing mutually increased risk. Recognizing this connection may can inform proactive approaches to disease prevention and management, potentially reducing the public health burden and improving quality of life.

Systematic Review Registration

https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024518323.
A hundred years of Pacific halibut management in the context of global events and trends in fisheries management
Authors: Hutniczak Barbara , Wilson David T. , Stewart Ian J. , Hicks Allan C.
Published: December 2024

The Convention for the Preservation of the Halibut Fisheries of the Northern Pacific Ocean, signed between Canada and the United States of America on 2 March 1923 and ratified on 21 October 1924, established the International Fisheries Commission, renamed in 1953 to the International Pacific Halibut Commission (IPHC). It was the first international agreement for joint management of a marine fishery resource and a major milestone for development of modern standards for marine conservation. The IPHC’s centennial year is an opportunity to celebrate a remarkable history of the Commission, but also reflect on challenges that shaped its mission. Born from alarms about overfishing during World War I, the Commission gradually gained authority to implement a wide range of conservation measures through established public confidence in its basis for decisions. This paper explores the evolution of management measures applied to Pacific halibut commercial fishing shaped not only by the changing stock conditions and growing demand for seafood, but also global events and trends in fisheries management. It examines the impact of rapid commercialization of fisheries driven by population growth and technological improvements, establishment of exclusive economic zones and altered access to fishing grounds, and adoption of Agenda 21, which highlighted the importance of balancing environmental, economic, and social aspects in fisheries management. It concludes by discussing the lessons learned over the past century and their implications for future fisheries management, emphasizing the importance of international cooperation, adaptive strategies, and science-based policies in sustaining transboundary fish stocks like the Pacific halibut.
The effects of a four-month skateboarding intervention on motor, cognitive, and symptom levels in children with ADHD
Authors: Christ Tabea , Boström Kim Joris , Ohrmann Patricia , Britz Henrike , Wagner Heiko , Bohn Christiane
Published: December 2024

Objectives and methods

This study aimed to investigate whether a four-month skateboarding workshop can positively affect attention-focusing skills and postural control in terms of static and dynamic balance in addition to symptoms of ADHD in school-aged children (N = 58). Kinematic and kinetic movement analysis, attention-focusing tests as well as symptom questionnaires were employed to measure differences caused by the skateboarding intervention. A weekly skateboarding workshop was conducted with children diagnosed with ADHD which intended to encourage children to autonomously engage in physical activity. Group differences were analyzed using a generalized linear mixed model. A partial correlation was used to investigate possible relationships between the variables.

Results

A preceding analysis confirmed that children with ADHD perform statistically significantly inferior in the employed tests of balance and concentration ability than unaffected peers of the same age. The main analysis showed that after the skateboarding intervention, children with ADHD were able to improve cognitive and motor test performances as well as symptom expression significantly. Significant improvements were likewise found in the waitlist control group, these were however less pronounced compared to those of the skateboarding intervention group. The correlation analysis revealed that there is no reciprocal influence between cognitive and motor skills, nor between motor skills and ADHD symptomatology in the present patient group. Possible explanations are discussed.

Conclusion

Skateboarding as a form of movement intervention can be considered an effective method for children with ADHD to deal with their symptoms and deficits. An intervention period of four months has helped children with ADHD discover and embrace an informal sport like skateboarding, thereby finding enjoyment in movement and practice a skill from intrinsic motivation. To retain the benefits, it is advisable to practice a sport on a long-term basis. Thorough conceptualizations to implement this type of therapy await further research.
Medication adherence in allergic diseases and asthma: a literature review
Authors: Malaya Elizabeth , Piątkowska Adrianna , Panek Michał , Kuna Piotr , Kupczyk Maciej , Kardas Grzegorz
Published: December 2024

Patients’ collaboration with healthcare providers, along with their individual dedication to follow medical recommendations, is a crucial component of effective therapy in chronic diseases. If a patient fails to fill their prescription, administers the medication improperly in terms of method and/or dosage, misses follow-up visits, or discontinues the treatment for any reason, these lapses can adversely affect disease management, impairing the effectiveness of symptom relief and prevention of progression and complications. A comparable situation pertains to allergic diseases, which require long-term and consistent treatment to achieve symptom alleviation and control. Research has shown that adherence rates for long-term therapy in chronic diseases have improved marginally over the years and continue to hover at approximately the figure published in a World Health Organization (WHO) report “Adherence to long-term therapies: evidence for action.” from 2003, which had stated that only 50% of patients in developed countries follow medical recommendations and that this rate would be even lower in developing countries. Over 20 years later, literature indicated that there has been only a slight improvement on the matter, leaving room for developing and implementing effective solutions to improve medication compliance. Further investigation on this matter is required. Causes for non-adherence classified by the Global Initiative for Asthma in their main report seem to correspond to those of the report by the WHO. Similar dependency might be determined by other allergic diseases as they fit chronic disease criteria, and the issue of non-adherence affects them too. This literature review seeks to compile and synthesize current insights on factors that influence adherence, as well as explore potential methods for monitoring, evaluating, and improving its outcomes in chronic diseases related to the medical field of allergology, such as asthma, allergic rhinitis, allergic conjunctivitis, rhinoconjunctivitis, atopic dermatitis, and urticaria.
Rural residents’ willingness to utilize primary care and its influencing factors in the context of graded diagnosis and treatment: a study in Deqing, China
Authors: Gao Meng , Zhu Xueqing
Published: December 2024

Background

Graded diagnosis and treatment is a key component in advancing healthcare system reforms and establishing a foundational healthcare framework. Primary care serves as the cornerstone of this system. Understanding the willingness to seek primary care and the factors influencing it can enhance primary care utilization and address the challenges of “difficult access to healthcare” and “high medical costs.”

Methods

This study, based on data from 415 rural residents in Deqing County, Zhejiang Province, analyzes their willingness to seek primary care and the factors influencing it using the Theory of Planned Behavior and structural equation modeling.

Results

The results of the study show the following: ① Attitude toward behavioral, subjective norm, and perceived behavior control significantly affect willingness to seek primary care, with attitude toward behavior having the greatest influence. ② Regarding attitude toward behavior, residents’ evaluation of treatment costs in primary care, the medical environment, and trust in doctors significantly impact their willingness to seek primary care. ③ In terms of subjective norms, the level of support from others, as well as the recognition of graded diagnosis and treatment systems and family doctor contracting services, positively influence the willingness to use primary care. ④ For perceived behavioral control, residents’ perception of personal and environmental factors affects their willingness to make a first visit to primary care facilities.

Conclusion

The study recommends strengthening the awareness of the necessity of primary care among rural residents, improving the experience at the primary level, stimulating the desire for primary care, and increasing the frequency of primary care utilization.
Challenges following CRS and HIPEC surgery in cancer patients with peritoneal metastasis: a comprehensive review of clinical outcomes
Authors: Karimi Mehdi , Shirsalimi Niyousha , Sedighi Eshagh
Published: December 2024

Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) are a pair of relatively modern therapeutic surgical methods in advanced cancerous patients with peritoneal metastasis (PM). The goal of CRS + HIPEC is treatment or to improve survival outcomes, which are linked to high morbidity side effects and complications, even with their possible advantages. Surgical-related, chemotherapy-related, anesthetic-related, gastrointestinal, organs and systemic complications are the categories into which complications are separated according to frequency, risk factors, and effect on patient outcomes. In this narrative review of the literature, the side effects and complications of HIPEC + CRS in cancer patients with PM are examined. The present knowledge on the incidence, frequency, kinds, and risk factors of acute complications following CRS + HIPEC is summarized in this study. This review emphasizes the need for careful patient selection criteria, precise surgical technique, and thorough intraoperative care to reduce or manage these risks. Moreover, it highlights the need for interdisciplinary collaboration in treating these patients. This study aims to know these complications, improve clinical practice, and guide future studies to increase the safety and efficacy of CRS + HIPEC in treating metastatic colorectal cancer.
Isolation and in vitro investigation on lactic acid bacteria for potential probiotic properties from cat feces
Authors: Wang Jiali , Yang Xue , Peng Yi , Zhang Jingyi , Huang Yixin , Zhong Zhijun , Liu Haifeng , Fu Hualin , Zhou Ziyao , Peng Guangneng
Published: December 2024

Background

Probiotics, which are beneficial to the host, have been shown to benefit the health of cats. Lactic acid bacteria (LAB) are commonly used probiotics, but most strains used for cats are not derived from cats, leading to reduced efficacy and poor adaptation to cats. The objective was to identify LAB with promising probiotic potential specific to cats.

Method

LABs were isolated from fecal samples of 20 healthy cats. Gram staining and the survival rate in the simulated gastrointestinal tract were used for preliminary screening. Candidate strains were identified by 16S rDNA sequencing, and further evaluated for adhesion ability, growth characteristics, antibacterial activity, antioxidant capacity, and safety.

Results

24 Gram-positive isolates were identified, with 10 (F1-F10) showing robust viability in the simulated gastroenteric fluid. These 10 strains exhibited excellent adhesion to Caco-2 cells and strong auto-agglutination properties. They also possessed the capacity to antagonize and aggregate pathogens (Staphylococcus aureus ATCC 25923, Salmonella Braenderup H9812, Escherichia coli ATCC 25922, and Pseudomonas aeruginosa PAO1), Moreover, all strains demonstrated tolerance to H2O2 concentrations ranging from 0.5–2 mmol/L and the ability to scavenge 1, 1-diphenyl-2-picrylhydrazyl (DPPH) free radicals, indicating a certain level of antioxidant activity. Safety tests showed no hemolytic activity, and all but F6 were highly sensitive to antibiotics, with over 62.5% sensitivity to 16 antibiotics. Remarkably, F4 (Lactobacillus reuteri) and F10 (Lactobacillus brevis) exhibited exceptional viability in the simulated gastrointestinal tract, coupled with robust growth potential, enhanced adhesion efficiency, significant antibacterial and antioxidant properties.

Conclusion

Our findings revealed that F4 (Lactobacillus reuteri) and F10 (Lactobacillus brevis) hold promising potential as probiotics. This research lays a solid scientific foundation for the selection and application of probiotics tailored specifically for cats.
Multi-Scenario Simulation of Optimal Landscape Pattern Configuration in Saline Soil Areas of Western Jilin Province, China
Authors: Ma Chunlei , Wang Wenjuan , Li Xiaojie , Ren Jianhua
Published: December 2024

The Songnen Plain is a significant region in China, known for its high grain production and concentrated distribution of soda saline land. It is also considered a priority area for cropland development in the country. However, the Songnen Plain is now facing prominent issues such as soil salinization, soil erosion, and deteriorating cropland quality, which are exacerbated by climate change and intensified human activities. In order to address these challenges, it is crucial to adjust the quantitative structure and layout of different landscapes in a harmonious manner, aiming to achieve synergistic optimization, which is posed as the key scientific approach to guide comprehensive renovation policies, improve saline–alkaline land conditions, and promote sustainable agricultural development. In this study, four scenarios including natural development, priority food production (PFP), ecological security priority (ESP), and economic–ecological-balanced saline soil improvement were set up based on Nondominated Sorting Genetic Algorithm II (NSGA-II) and the Future Land Use Simulation (FLUS) model. The results demonstrated that the SSI scenario, which focused on economic–ecological equilibrium, displayed the most rational quantitative structure and spatial layout of landscape types, with total benefits surpassing those of the other scenarios. Notably, this scenario involved converting unused land into saline cropland and transforming saline cropland into normal cropland, thereby increasing the amount of high-quality cropland and potential cropland while enhancing the habitat quality of the region. Consequently, the conflict between food production and ecological environmental protection was effectively mitigated. Furthermore, the SSI scenario facilitated the establishment of a robust ecological security and protection barrier, offering valuable insights for land use planning and ecological security pattern construction in the Songnen Plain, particularly in salt-affected areas.
Seed Inoculation with Halotolerant Strains Enhance Brassicaceae Seedling Establishment Under Saline Conditions
Authors: González-Cobo Carlos , Escolà Glòria , Tolrà Roser , Llugany Mercè , Poschenrieder Charlotte , Bianucci Eliana , Busoms Silvia
Published: December 2024

Soil salinity inhibits germination and seedling establishment, causing patchy crop stands, uneven growth, and poor yields. This study aims to evaluate the early-stage salinity tolerance of Brassicaceae seeds inoculated with plant growth-promoting bacterial (PGPB) strains (E1 and T7) isolated from saline soils. Non-inoculated and inoculated seeds of Lobularia maritima, Sinapis alba, and Brassica napus were cultivated under control and salinity conditions, first in agar plates to assess a germination inhibitory concentration of salt for each species and later in soil irrigated with water containing 0 or 75 mM NaCl. Our results indicate that T7 was the only strain able to increase the germination of L. maritima under saline conditions. However, an increase in shoot biomass, root length, and number of branches was observed in L. maritima and S. alba plants inoculated with T7 and in B. napus with E1. Concomitantly, those seedlings exhibited less oxidative damage and greater capacity to balance plant reactive oxygen species production. This study suggests that inoculation of seeds with halotolerant PGPB strains is a suitable strategy for improving the negative effects of salinity in the early stages. Nonetheless, the observed specific plant–host interaction highlights the need for establishing tailored PGPB–crop associations for specific unfavourable environmental conditions.
Investigating the Impact of Agricultural Credit on Wheat Farming: Evidence from Pakistan
Authors: Larik Shahbaz Ali , Amin Asad , Gul Amber , Panhwar Paruss , Murtaza Sahito Jam Ghulam , Hua Guo
Published: December 2024

Increasing food production is crucial for attaining the Sustainable Development Goal (SDG#2) by 2030 through supplying agricultural credit and improved inputs. Thus, the present study examined the roles of agricultural credit, applications of fertilizer, usage of pesticides, farming area, and agricultural employment in enhancing wheat production in the developing economy (Pakistan) from 1990 to 2020. This study applied the autoregressive distributed lag (ARDL) regression method for the empirical analysis. The empirical findings from the ARDL regression technique revealed that agricultural credit can significantly enhance wheat production, while improved inputs, including fertilizer and pesticide usage, also positively contribute to wheat production. Notably, agriculture credit plays a vital role in assisting farmers to purchase advanced farm inputs and indirectly increases the wheat yield. Consequently, this study suggests that the banking sector should supply agricultural credit to farmers under flexible lending conditions; therefore, farmers can easily access credit and adopt modern technologies to enhance food production and ensure food security.
YOLO-IAPs: A Rapid Detection Method for Invasive Alien Plants in the Wild Based on Improved YOLOv9
Authors: Huang Yiqi , Huang Hongtao , Qin Feng , Chen Ying , Zou Jianghua , Liu Bo , Li Zaiyuan , Liu Conghui , Wan Fanghao , Qian Wanqiang , Qiao Xi
Published: December 2024

Invasive alien plants (IAPs) present a significant threat to ecosystems and agricultural production, necessitating rigorous monitoring and detection for effective management and control. To realize accurate and rapid detection of invasive alien plants in the wild, we proposed a rapid detection approach grounded in an advanced YOLOv9, referred to as YOLO-IAPs, which incorporated several key enhancements to YOLOv9, including replacing the down-sampling layers in the model’s backbone with a DynamicConv module, integrating a Triplet Attention mechanism into the model, and replacing the original CIoU with the MPDloU. These targeted enhancements collectively resulted in a substantial improvement in the model’s accuracy and robustness. Extensive training and testing on a self-constructed dataset demonstrated that the proposed model achieved an accuracy of 90.7%, with the corresponding recall, mAP50, and mAP50:95 measured at 84.3%, 91.2%, and 65.1%, and a detection speed of 72 FPS. Compared to the baseline, the proposed model showed increases of 0.2% in precision, 3.5% in recall, and 1.0% in mAP50. Additionally, YOLO-IAPs outperformed other state-of-the-art object detection models, including YOLOv5, YOLOv6, YOLOv7, YOLOv8, YOLOv10 series, Faster R-CNN, SSD, CenterNet, and RetinaNet, demonstrating superior detection capabilities. Ablation studies further confirmed that the proposed model was effective, contributing to the overall improvement in performance, which underscored its pre-eminence in the domain of invasive alien plant detection and offered a marked improvement in detection accuracy over traditional methodologies. The findings suggest that the proposed approach has the potential to advance the technological landscape of invasive plant monitoring.