bluuebunny/crossref_metadata_2025 huggingface dataset:
Nutrients and Antioxidants from Petit Verdot Grape Pomace Powder
Authors:   Departamento de Ciencias Químico-Biológicas. Universidad de Sonora. Rosales y Luis Encinas s/n. Colonia Centro. C.P.83000, Garay-Dominguez Anette Karina , Quintana-Obregón Eber Addí ,   CONAHCYT-Centro de Investigación en Alimentación y Desarrollo. Coordinación de Tecnología de Alimentos de Origen Vegetal. Hermosillo, Sonora, México, Sánchez-Mariñez Reyna Isabel ,   Departamento de Ciencias Químico-Biológicas. Universidad de Sonora. Rosales y Luis Encinas s/n. Colonia Centro. C.P.83000, Corrales-Maldonado Consuelo Guadalupe ,   Centro de Investigación en Alimentación y Desarrollo. Coordinación de Ciencia de los Alimentos, Hermosillo, Sonora, México, Ramos-Enríquez José Rogelio ,   Departamento de Ciencias Químico-Biológicas. Universidad de Sonora. Rosales y Luis Encinas s/n. Colonia Centro. C.P.83000
Published: September 2024

T he study aimed to characterize pomace powder from the Petit Verdot grape of Mexican winemaking. The powder pomace (dry basis from pomace) was analyzed and contained 6.65% moisture, 9.17% fat, 9.54% protein, 51.41% dietary fiber, 6.10% soluble fiber, 45.3% insoluble fiber, and 4.62% ash. Also, the powder pomace contained various minerals, including calcium, copper, phosphorus, iron, magnesium, manganese, sodium, and potassium. The phenolic compounds found were hydrated quercetin, a cinnamic acid derivative, and a p-coumaric acid derivative. The limited diversity of phenolics in grape pomace powder is counterbalanced by its elevated dietary fiber and nutritional content, positioning it as a viable ingredient for food processing. The freeze-dried grape pomace powder contained a load of 4 log CFU/g, and the MacConkey culture medium detected no possible pathogenic microorganisms. These findings suggest that grape pomace powder could be a promising addition to the food industry, offering a rich source of nutrients and bioactive compounds.
Timing impact on the initiation of pirfenidone therapy on idiopathic pulmonary fibrosis disease progression
Authors: Mohamed Basma M E , Abdelrahim Mohamed E A
Published: September 2024

In this editorial, we comment on the article by Lei et al, with a specific focus on the timing of the initiation of the antifibrotic agent pirfenidone (PFD) in the management of idiopathic pulmonary fibrosis (IPF) and its impact on lung function of IPF patients. PFD is an antifibrotic agent that is widely used in the management of IPF in both early and advanced stages. It inhibits various pathways and has antifibrotic, anti-inflammatory, and antioxidant properties. Despite dosage lowering, PFD slowed IPF progression and maintained functional capacity. The 6-min walk distance test indicated that patients tolerated adverse events well, and PFD significantly reduced the incidence of progression episodes and death. Even when a single disease-progression event occurred, continuing PFD treatment had benefits.
Immunoglobulin G4-related spinal pachymeningitis: A case report
Authors: Chae Tae-Seok , Kim Da-Sol , Kim Gi-Wook , Won Yu Hui , Ko Myoung-Hwan , Park Sung-Hee , Seo Jeong-Hwan
Published: September 2024

BACKGROUND

Immunoglobulin G4-related disease (IgG4-RD) is a complex immune-mediated condition that causes fibrotic inflammation in several organs. A significant clinical feature of IgG4-RD is hypertrophic pachymeningitis, which manifests as inflammation of the dura mater in intracranial or spinal regions. Although IgG4-RD can affect multiple areas, the spine is a relatively rare site compared to the more frequent involvement of intracranial structures.

CASE SUMMARY

A 70-year-old male presented to our hospital with a two-day history of fever, altered mental status, and generalized weakness. The initial brain magnetic resonance imaging (MRI) revealed multiple small infarcts across various cerebral regions. On the second day after admission, a physical examination revealed motor weakness in both lower extremities and diminished sensation in the right lower extremity. Electromyographic evaluation revealed findings consistent with acute motor sensory neuropathy. Despite initial management with intravenous immunoglobulin for presumed Guillain-Barré syndrome, the patient exhibited progressive worsening of motor deficits. On the 45th day of hospitalization, an enhanced MRI of the entire spine, focusing specifically on the thoracic 9 to lumbar 1 vertebral level, raised the suspicion of IgG4-related spinal pachymeningitis. Subsequently, the patient was administered oral prednisolone and participated in a comprehensive rehabilitation program that included gait training and lower extremity strengthening exercises.

CONCLUSION

IgG4-related spinal pachymeningitis, diagnosed on MRI, was treated with corticosteroids and a structured rehabilitation regimen, leading to significant improvement.
Adesão ao tratamento da hipertensão arterial sistêmica na Atenção Primária à Saúde: uma revisão integrativa de literatura
Authors: Batista Ferro Gustavo , Victória Barbosa Flexa Carla , Lucas Farias Lima Igor , Do Socorro Maciel Quaresma Mariana , Moraes de Moraes Thayse
Published: September 2024

Introdução: A hipertensão arterial sistêmica (HAS) é um problema fisiológico de caráter crônico e multifatorial associado a diversas comorbidades. Desse modo, o diagnóstico dessa condição pressupõe diversos fatores de riscos vinculados aos hábitos de vida do paciente, além do risco de desencadear outras alterações, como consequência dos níveis elevados de pressão suportados pelos vasos arteriais. Objetivo: Identificar os fatores que interferem no processo de adesão ao tratamento da hipertensão na atenção primária. Metodologia: Foi realizada uma revisão integrativa de literatura. Para a composição da revisão, foram feitas buscas nas bases SciELO, LILACS e PubMed utilizando descritores e operadores booleanos, durante julho a agosto de 2021. Resultados: Na busca inicial, foram encontrados 187 estudos. Aplicando-se os critérios de inclusão, restaram 16 para a formulação do trabalho. Os estudos possibilitaram identificar a HAS como um importante problema de saúde na atenção primária. Em relação à adesão ao tratamento, fatores como apoio familiar, hábitos de vida, aspectos culturais e educação em saúde são influenciadores da terapêutica seguido pelo paciente. Conclusão: Estilos de vida saudáveis e uma boa educação em saúde nas unidades de atenção primária são fundamentais na adesão ao tratamento, podendo favorecer à redução dos medicamentos ou até mesmo sua dispensa, conforme o caso.
Adesão ao tratamento medicamentoso da tuberculose pulmonar: uma revisão integrativa
Authors: Oliveira Freitas Jacqueline , Da Hora Brito Acácia , De Oliveira Araujo Mariana de Oliveira , De Oliveira Araujo Bianca
Published: September 2024

Introdução: A tuberculose é uma doença infecciosa que mata muitas pessoas no mundo, sendo a adesão ao seu tratamento e as reduzidas taxas de cura desafios para o seu controle. Objetivo: Descrever as facilidades e dificuldades na adesão ao tratamento medicamentoso da tuberculose pulmonar. Metodologia: Revisão integrativa, com levantamento online no portal da Biblioteca Virtual em Saúde, nas Bases de Dados Literatura Latino-Americana e do Caribe em Ciências da Saúde e Banco de Dados em Enfermagem, usando os descritores: Tuberculose AND Tratamento Farmacológico AND Acesso à Medicação. Foram selecionados 11 artigos, sendo realizada análise descritiva com criação das categorias: “Facilidades na adesão ao tratamento medicamentoso da tuberculose pulmonar” e “Dificuldades na adesão ao tratamento medicamentoso da tuberculose pulmonar”. Resultados: Destacam-se como facilidades a prática de hábitos saudáveis, distribuição de cestas básicas, vale transporte, orientação, vínculo, Tratamento Diretamente Observado e descentralização do diagnóstico. Entre as dificuldades, destaca-se baixa escolaridade e renda, acesso aos serviços de saúde, não aceitação da doença, etilismo, tabagismo, falsa percepção de cura, falta de profissionais, reações adversas e período longo da terapia. Conclusão: Salienta-se a relevância da criação de estratégias apropriadas às demandas do usuário que busquem promover a adesão ao tratamento medicamentoso da tuberculose pulmonar.
Aquilombamento como ferramenta de resistência e promoção de saúde da população negra
Authors: Menezes Rimoli Thaís , Menezes Bragança dos Santos Ana Paula , De Jesus Alves Pires Laurenice , Costa Mendes Ernani
Published: September 2024

Compreende-se o aquilombamento aqui proposto como movimento histórico, político e cultural de resgate e valorização de saberes ancestrais que une narrativas, coletiviza dores e amores, constrói futuros e confronta a perpetuação do racismo estrutural. O racismo é considerado o principal determinante social em saúde para a população negra e se atualiza nas instituições de ensino e nas Redes de Atenção Psicossocial. Neste trabalho, buscou-se conhecer a relação entre saúde e práticas exclusivas de pessoas negras e a importância do aquilombamento na promoção de saúde para esta população. Foi realizada uma pesquisa exploratória de abordagem qualitativa, por meio de pesquisa bibliográfica na Biblioteca Virtual em Saúde. Os artigos encontrados foram discutidos sob a ótica do quilombismo de Abdias Nascimento e a visão de Beatriz Nascimento acerca do que é um quilombo. Conclui-se que, além, do aquilombamento já realizado pelas pessoas negras, enquanto modo de vida, faz-se necessário aquilombar, também, os currículos escolares, bem como as epistemologias científicas, os espaços e as políticas de atendimento à saúde.
Relação entre funcionalidade e qualidade de vida em mulheres com linfedema periférico
Authors: Martins Bernal da Silva João Vitor , Francklin da Silva Rafael , Valadares da Silva Adriana , Colombini Buranello Mariana
Published: September 2024

Introdução: O linfedema periférico é uma condição crônica e incurável que causa inchaço, inflamação e pode levar a infecções, prejudicando a qualidade de vida e a funcionalidade do indivíduo. Objetivo: Investigar a relação entre funcionalidade e qualidade de vida em mulheres com linfedema periférico, tanto de membros superiores quanto de membros inferiores. Métodos: Trata-se de um estudo observacional do tipo transversal realizado em mulheres com linfedema periférico. Foram utilizados os questionários SF-36, DASH, Lymph-ICF-LL e a Escala Visual Analógica de Dor. Os dados foram coletados, tabulados em uma planilha do Excel e, posteriormente, analisados estatisticamente. Resultados: A amostra do estudo apresentou idade média de 59,2 anos e predominância de linfedema em membros inferiores. Em relação à comparação entre o grupo de pacientes com linfedema em membros superiores e o grupo de pacientes com linfedema em membros inferiores, foi observada diferença significativa nas variáveis peso e IMC. Além disso, em pacientes com linfedema periférico de membros inferiores, foi constatado uma correlação moderada negativa entre funcionalidade e qualidade de vida. Conclusão: Infere-se que, em pacientes com linfedema de membros inferiores, à medida que o linfedema aumenta seu impacto na funcionalidade, a qualidade de vida diminui.
Sistematização da assistência e do processo de enfermagem: um relato de experiência em saúde mental
Authors: Bardaquim Vanessa Augusto , Gonçalves Dias Ernandes , Robazzi Maria Lúcia do Carmo Cruz
Published: September 2024

Introdução: O uso crônico e excessivo de substâncias psicotrópicas é considerado patológico e os Centros de Atenção Psicossocial Álcool e outras Drogas são ambientes de atenção à saúde voltados a tratar os dependentes químicos. Objetivo: Relatar a experiência de adaptação da Sistematização da Assistência de Enfermagem e do Processo de Enfermagem em consultas realizadas em uma unidade de saúde mental pública, por meio da Classificação Internacional para as Práticas de Enfermagem em Saúde Coletiva. Método: Relato de experiência, descritivo, realizado em um Centro de Atenção Psicossocial modalidade Álcool e outras Drogas, no período de julho a outubro de 2022, com usuários de substâncias psicoativas. Resultados: A Sistematização da Assistência de Enfermagem é um processo de execução difícil para enfermeiros na área da saúde mental, pois, atualmente, a maior parte dos prontuários ainda estão disponíveis em meio físico, o que dificulta o trabalho da rede de atenção do Sistema Único de Saúde. Assim, foi implementado um instrumento utilizado para coleta e registro de dados no Centros de Atenção Psicossocial Álcool e outras Drogas, do usuário com o Diagnóstico de Enfermagem Uso de álcool e outras drogas e as Prescrições de Enfermagem mais recorrentes, atendidos no serviço público. Conclusão: A Sistematização da Assistência de Enfermagem é uma ferramenta laboral essencial para o acompanhamento e eficácia do tratamento ambulatorial, além de minimizar os danos decorrentes do uso de substâncias psicotrópicas, é útil para a reinserção social do indivíduo e facilita o trabalho do enfermeiro.
Caracterização da oferta e infraestrutura dos serviços de prótese dentária na Atenção Primária à Saúde da Bahia
Authors: De Souza Santos Lília Paula , Cerqueira das Neves de Brito Hévila , Silva de Oliveira Cruz Larissa
Published: September 2024

Introdução: A perda dentária é um problema de saúde pública significativo no Brasil, afetando uma grande parcela da população em diferentes faixas etárias. Assim, a Política Nacional de Saúde Bucal recomenda a inclusão da reabilitação protética nos serviços de Atenção Primária. Neste sentido, este trabalho tem como objetivo descrever as características dos serviços de prótese dentária ofertados na atenção primária do estado da Bahia. Metodologia: Trata-se de um estudo descritivo com análise de dados secundários provenientes do 3º ciclo do PMAQ-AB, relativos à avaliação externa das Equipes de Saúde Bucal e das Unidades Básicas de Saúde da Bahia, coletados em 2017. Participaram da avaliação 2.106 equipes. Resultados: A cimentação de prótese era realizada em 49,6% dos municípios, a instalação de prótese em 25,4%, a moldagem para prótese em 24,7%. Porém, verificou-se ausência de materiais e equipamentos necessários para a realização de procedimentos de prótese dentária, como espátula para gesso e alginato (81,7%), lamparina (83,1%), moldeiras (79,8%), gesso (85,0%), dentes de estoque (87,6%), fresa metálica (81,7%) e resina acrílica (80%), mesas vibratórias para gesso (96,2%). Ainda, uma única equipe soube informar quanto à oferta de próteses bucomaxilofaciais pela rede de atenção à saúde. Conclusão: Os resultados demonstraram um percentual baixo de equipes e municípios que realizam procedimentos de prótese na Atenção Primária na Bahia e uma escassez de materiais e insumos necessários para a oferta dos serviços de prótese dentária.
Violência física contra mulheres: revisão integrativa no campo da saúde
Authors: Ribeiro Ferreira Pâmela Gabrielle , Patrocino Laís , Dumont-Pena Érica , Ferreira Lachtim Sheila Aparecida
Published: September 2024

A violência física contra mulheres constitui uma das formas de violência de alta prevalência no Brasil. Suas implicações para a saúde integral são de amplo reconhecimento. Objetivou-se conhecer as produções científicas no cenário brasileiro acerca das mulheres com lesões corporais decorrentes da violência de gênero. Procedeu-se a uma revisão integrativa, realizada em agosto de 2021, em diversas bases de dados. A busca de artigos ocorreu por meio da seleção do tema nos Descritores em Ciências da Saúde e dos critérios de inclusão e exclusão. As produções resultam das áreas de enfermagem, odontologia e psicologia. Esses estudos descrevem o perfil das mulheres que sofreram violência física, sendo elas, principalmente, mulheres na faixa de idade entre 20 e 40 anos, casadas, com menos de oito anos de estudos e que exercem atividades relacionadas ao ambiente doméstico. As lesões mais características são as que atingem a face e os membros superiores. As publicações não trazem reflexões sobre o cuidado prestado às mulheres, suas possibilidades técnicas e tecnologias. O trabalho permitiu identificar a necessidade de aprimoramento das discussões acerca das mulheres em situação de agressão física, considerando a especificidade da violência de gênero, especialmente as potencialidades e os desafios do cuidado.
Fatores relacionados ao óbito por COVID-19: estudo transversal em município catarinense
Authors: Pereira Corrêa Vanessa , Reis da Silveira Edenice , Rodrigues da Luz Jaíne , Vanti da Rocha Bruna
Published: September 2024

Objetivo: Compreender os fatores relacionados aos óbitos de Síndrome Respiratória Aguda Grave (SRAG) por COVID-19, no município de Itajaí, Santa Catarina. Métodos: Estudo transversal com dados públicos do DataSUS, sobre as hospitalizações por SRAG notificadas por ocorrência no município, entre a 1ª/2020 – 52ª/2021 semana epidemiológica.  Os resultados foram expressos em frequências absolutas, relativas e razão de chance (análise de dados completos) com seus respectivos IC95%. Todas as análises foram realizadas no Stata 16.0. Resultados: De 2.297 casos de SRAG, 51,7% foram notificados como SRAG por COVID-19. O perfil dos óbitos e das hospitalizações foram semelhantes - sexo masculino (54,9%), com 60 anos ou mais (45,1%), cor da pele branca (87,4%) e com ensino fundamental (56,4%). No entanto, em análise bivariada, o estudo mostra maior frequência de óbitos naqueles que historicamente são marginalizados: negros, indígenas e pessoas de baixa escolaridade. Ser da faixa etária entre 20 e 39 anos diminuiu as chances de óbitos por SRAG por COVID-19 quando comparado à faixa etária entre 0-12 anos (OR: 0,71 (0,60-0,85).
Características sociodemográficas e clínicas de indivíduos com câncer de próstata em Minas Gerais, 2014-2019
Authors: Quintão Vila Real Keila Cristina Machado , Rodrigues Suely Maria , Gomes Barbosa Nogueira Bernardo
Published: September 2024

Objetivo: Este estudo objetivou identificar as características sociodemográficas e clínicas de indivíduos com câncer de próstata, no período de 2014 a 2019, atendidos em hospitais públicos e privados conveniados ao Sistema Único de Saúde (SUS), em Minas Gerais. Método: Trata-se de um estudo epidemiológico do tipo ecológico, de abordagem quantitativa, utilizando 24.685 Registros Hospitalares de Câncer (RHC). As variáveis estudadas foram: idade, raça/cor, escolaridade, estado conjugal, fatores de risco e histórico da doença. Resultados: Em relação ao perfil sociodemográfico a amostra estudada é idosa, possui baixa escolaridade, casada ou vive com companheiro(a), com relato de consumo de tabaco e não etilista. Quanto ao histórico clínico, não há antecedente familiar de câncer, a doença estava em estágio avançado (II a IV), o primeiro tratamento recebido no ambiente hospitalar foi a cirurgia e o protocolo de encaminhamento foi referenciado/originado no SUS. Conclusão: Pode-se concluir que grande parte dos indivíduos foi diagnosticado em estágios mais avançado da doença. O conhecimento das características dos homens acometidos com câncer de próstata poderá nortear políticas públicas direcionadas para essa população.
Ultrasound: Ankle and Foot Blocks
Authors:   Anaesthesia & OT Services, Asian Hospital, Faridabad, Haryana, India., Arora Divesh
Published: September 2024

Ankle blocks are regional anaesthetic techniques used for foot surgery and pain management. Traditionally performed with anatomical landmarks, ultrasound-guided ankle and foot blocks have emerged as a pivotal technique in regional anaesthesia, offering enhanced precision and safety over traditional methods. This review article examines the current practices in ultrasound-guided ankle and foot blocks, including the necessary equipment, sonoanatomy, and injection techniques for various nerves. This comprehensive review aims to equip anaesthesiologists with the knowledge to effectively implement ultrasound-guided ankle and foot blocks, ultimately optimizing pain management and procedural success in lower extremity interventions. Keywords: Ankle block, Ultrasound guidance, Foot and ankle surgery
Improving cone identification using merged non-confocal quadrant-detection adaptive optics scanning light ophthalmoscope images
Authors: Chui Toco Y. P. , Migacz Justin V. , Muncharaz Duran Luis , Haq Affan , Otero-Marquez Oscar , Dubra Alfredo , Rosen Richard B.
Published: September 2024

Cone photoreceptor inner segments visualized in non-confocal split-detection adaptive optics scanning light ophthalmoscope (AOSLO) images appear as obliquely illuminated domes with bright and dark opposing regions. Previously, the pairing of these bright and dark regions for automated photoreceptor identification has necessitated complex algorithms. Here we demonstrate how the merging of split-detection images captured with a non-confocal quadrant light detection scheme allows automated cone identification using simple, open-source image processing tools, while also improving accuracy in both normal and pathologic retinas.
Spatiotemporal Bragg gratings forming inside a nonlinear dispersive medium
Authors: Zhang Junchi , Donaldson W. R. , Agrawal Govind P.
Published: September 2024

We show that a spatiotemporal Bragg grating can be created inside a nonlinear dispersive medium (such as silica fibers) by launching a periodic train of pump pulses that travel as fundamental solitons. We develop a theoretical model and use it to find the band structure of such gratings. We study the interaction of a probe pulse with the Bragg grating, both within and outside of momentum gaps. We also show that a photonic analog of the Anderson localization is possible when a disorder is introduced into a spatiotemporal Bragg grating.
Enhancing stimulated Brillouin scattering in suspended silicon waveguides through subwavelength nanostructuration [Invited]
Authors: González-Andrade David , Nuño Ruano Paula , Zhang Jianhao , Cassan Eric , Marris-Morini Delphine , Vivien Laurent , Lanzillotti-Kimura Norberto Daniel , Alonso-Ramos Carlos
Published: September 2024

Brillouin optomechanics is playing a key role in the development of groundbreaking devices and novel functionalities in integrated silicon photonics, such as narrow linewidth filtering and lasers, tunable frequency, non-reciprocity, etc. Most silicon-based optomechanical waveguides, which use anchoring arms or perforated slabs to ensure mechanical stability and operate for transverse-electric polarized light, face challenges with acoustic mode leakage into the lateral Si slab, limiting the photon-phonon overlap and the Brillouin gain. Here, we propose new waveguide designs based on subwavelength nanostructuration to tailor near-infrared photons and GHz phonons and maximize the Brillouin gain. We introduce six different geometries suitable for both membrane or fully suspended configurations (i.e., without transversal arms anchoring the core to the Si slab). Our three-dimensional optomechanical simulations predict that subwavelength silicon membranes with strip, slot, and SWG slot core waveguides achieve gains up to 12257 W-1m-1 at mechanical frequencies of 12-13 GHz. Moreover, suspended silicon waveguides with SWG slots achieve a high gain of 43542 W-1m-1 at 4.45 GHz, with the ability to adjust the mechanical frequency from 4 to 9 GHz. Further enhancements in the Brillouin gain are studied by integrating side arms to amplify the moving boundaries effect in the suspended SWG slot waveguides and leveraging the slow light regime, which can significantly increase the Brillouin gain up to 17 × 106 W-1m-1 for a mechanical mode at 11.18 GHz.
Anomalous infrared conical emission during ordered multifilamentation in gases
Authors: Pushkarev Dmitrii , Bulygin Andrey , Zhidovtsev Nikita , Uryupina Daria , Volkov Roman , Geints Yuri , Savelev Andrei
Published: September 2024

We demonstrate that amplitude modulation of a high-power femtosecond laser pulse allows to change fundamentally frequency-angular structure of the supercontinuum formed during the filamentation in both molecular and atomic gases. Particularly, modulation with a 4-hole mask strongly suppresses conical emission in the anti-Stokes wing of pulse spectrum with simultaneous enhancement in the Stokes band. We explain this phenomenon as a joint effect of diffraction, self-phase modulation and temporal pulse splitting of interfering beamlets formed by the modulation mask. Our results pave a way for tailoring the frequency-angular structure of filament-generated supercontinuum.
Ptychographic wavefront cameras
Authors: Brady David , Chen Ni
Published: September 2024

We introduce a snapshot wavefront camera capable of reconstructing the complex field of an object with near quantum-limited accuracy. This system incorporates a diffraction grating at the entrance aperture and an array of cameras positioned to align with the grating orders, capturing the field with varying impulse responses. The camera effectively reconstructs both the amplitude and phase of the object. Key performance factors include the aperture size, number of apertures, and the overlap ratio between adjacent apertures. The minimal imaging and computational performance could be obtained using a 3x3 camera array configuration.
Full-space programmable circularly polarized metasurface for space-multiplexing wireless communications
Authors: Zheng Sen , Zhang Lei , Zheng Yi Ning , Gou Yue , Wang Zheng Xing , Xiao Qiang , Ma Qian , Wang Hai Lin , Cheng Zhang Wen , Cui Tie Jun , Ma Hui Feng
Published: September 2024

The programmable metasurface has been proved to be an effective tool to dynamically tailor electromagnetic (EM) waves. However, how to achieve real-time and independent controls of circularly polarized (CP) waves in the transmission and reflection spaces is still a challenge. To address this problem, we propose a full-space programmable CP metasurface, which can independently manipulate the CP waves in transmission and reflection spaces in real time by controlling the bias voltage. The polarization states of reflected and transmitted CP waves can be independently customized through elaborate meta-atom design. As a proof of concept, we designed, fabricated, and measured a full-space programmable CP metasurface that can realize copolarized reflection for right-handed circularly polarized (RCP) waves and cross-polarized transmission for left-handed circularly polarized (LCP) waves. Simulated and measured results verify that the wavefronts of reflected and transmitted CP waves can be independently manipulated in real time by reprogramming the reflection and transmission phase coding sequences. Based on the full-space programmable CP metasurface, a space-multiplexing wireless communication scheme is established, successfully delivering two different images along preset reflection and transmission channels.
TCP BBR-n interplay with modern AQM in Wireless-N/AC networks: Quest for the golden pair
Authors: Ahsan Muhammad , Muhammad Sajid S.
Published: September 2024

Effective congestion control on the internet has been a problem since its inception. Transmission Control Protocol (TCP), being the most widely used transport layer protocol tries to mitigate it using a variety of congestion control algorithms. Cubic, Reno, and Bottleneck Bandwidth and Round-trip propagation time (BBR) are the most deployed congestion controls. BBR v2 is leading the congestion control race with its superior performance in terms of better throughput and lower latency. Furthermore, Active Queue Management (AQM) algorithms try to mitigate the congestion control at the network layer through active buffer control to avoid bufferbloat. The most efficient congestion control occurs when TCP and AQM work together. Indeed, it is the TCP-AQM algorithm “Golden pair” that can result in the most efficient performance. This paper proposes such a novel pair based on our previously tested and published BBR-n (BBR new) with the most effective of the modern AQMs, that completely gels together to provide lower latency in wireless networks based on Wireless N/AC. Real-time experiments were performed using Flent on our physical testbed with BBR-n and modern AQMs such as Fair Queuing (FQ), Constrained Delay (CoDel), Proportional Integral controller Enhanced (PIE), Common Applications Kept Enhanced (Cake) and Flow Queuing Controlled Delay (FQ_CoDel). Various tests done on our physical testbed helped us identify CAKE as the most optimum AQM that fits with our proposed BBR-n while providing optimum throughput and lower latency in 802.11N/AC-based wireless networks.
Living donors kidney transplantation and oxidative stress: Nitric oxide as a predictive marker of graft function
Authors: Izemrane Djamila , Benziane Ali , Makrelouf Mohamed , Hamdis Nacim , Rabia Samia Hadj , Boudjellaba Sofiane , Baz Ahsene , Benaziza Djamila
Published: September 2024

Background

Glomerular filtration rate is the best indicator of renal function and a predictor of graft and patient survival after kidney transplantation.

Methods

In a single-centre prospective analysis, we assessed the predictive performances of 4 oxidative stress biomarkers in estimating graft function at 6 months and 1 year after kidney transplantation from living donors. Blood samples were achieved on days (D-1, D1, D2, D3, D6 and D8), months (M1, M3 and M6) and after one year (1Y). For donors, a blood sample was collected on D-1. Malondialdehyde (MDA), nitric oxide (NO), glutathione s-transferase (GST), myeloperoxydase (MPO), and creatinine (Cr) were measured by spectrophotometric essays. The estimated glomerular filtration rate by the modification of diet in renal disease equation (MDRD-eGFR) was used to assess renal function in 32 consecutive donor-recipient pairs. Pearson’s and Spearman’s correlations have been applied to filter out variables and covariables that can be used to build predictive models of graft function at six months and one year. The predictive performances of NO and MPO were tested by multivariable stepwise linear regression to estimate glomerular filtration rate at six months.

Results

Three models with the highest coefficients of determination stand out, combining the two variables nitric oxide at day 6 and an MDRD-eGFR variable at day 6 or MDRD-eGFR at day 21 or MDRD-eGFR at 3 months, associated for the first two models or not for the third model with donor age as a covariable (P = 0.000, r2 = 0.599, r2adj = 0.549; P = 0.000, r2 = 0.548, r2adj = 0.497; P = 0.000, r2 = 0.553, r2adj = 0.517 respectively).

Conclusion

Quantification of nitric oxide at day six could be useful in predicting graft function at six months in association with donor age and the estimated glomerular filtration rate in recipient at day 6, day 21 and 3 months after transplantation.
Development of SSR markers for genetic diversity analysis and species identification in Polygonatum odoratum (Mill.) Druce based on transcriptome sequences
Authors: Pan Gen , Xie Jing , Qin Yuhui , Zhang Shuihan
Published: September 2024

Polygonatum odoratum (Mill.) Druce is a well-known traditional Chinese herb belonging to the Polygonatum. However, the understanding of the genetic diversity of this species at the molecular level is limited due to the lack of transcriptomic and genomic information. In this study, 37,387 unigenes were assembled based on the transcriptome sequencing of the rhizome of Polygonatum odoratum (Mill.) Druce., and 11,021 single- sequence repeats (SSR) motifs, mainly consisting of single-nucleotide repeats (44.44%), dinucleotides (31.06%), and trinucleotides (22.59%), were identified. Based on these SSR motifs, 9,987 primer pairs of SSR markers were designed and 68 SSR markers were randomly selected for verification, of which 21 SSR markers showed polymorphisms among the 24 Polygonatum odoratum germplasms. Ninety-four alleles were detected: the observed alleles ranged from 2 to 11, the effective alleles varied from 1.086 8 to 4.916 8, the Shannon diversity index was 0.173 2~1.749 7, and the polymorphism information content PIC ranged from 0.076 7 to 0.803 9. Based on our analysis of genetic diversity (SSR genotypes) and population structure, we divided the 24 germplasm resources into two groups, indicating that the germplasm with similar geographical origins can be grouped together. In addition, the primers ‘YZ14’ and ‘YZ47’ could effectively distinguished the related species: Polygonatum kingianum Coll.et Hemsl., Polygonatum sibiricum Red., Polygonatum cyrtonema Hua, Polygonatum zanlanscianense Pamp. and Polygonatum odoratum (Mill.) Druce. This is the first study in which a dataset of expressed sequence tag (EST)-SSR markers is constructed for the Polygonatum odoratum (Mill.) Druce, and these newly developed EST-SSR markers provided a very efficient tool for genetic relationship analysis, species identification and marker-assisted selection breeding of Polygonatum odoratum (Mill.) Druce.
Association between waist circumference and sleep disorder in the elderly: Based on the NHANES 2005–2018
Authors: Zhong Yuting , Li Ying , Zhong Maolin , Peng Cheng , Zhang Hui , Tian Kejun
Published: September 2024

The existing data do not consistently support the link between elderly adults’ waist circumferences and sleep disorders. This study aimed to evaluate whether waist circumference was connected with sleep disorder in the elderly. This cross-sectional study utilized data from the 2005–2018 National Health and Nutrition Examination Survey (NHANES) regarding waist circumference, sleep disorders, and confounding factors. Included in the study were participants older than 60 who completed sleep questionnaires and waist circumference measurements. Using a multivariate logistic regression model and subgroup analyses, the relationship between waist circumference and sleep disorder was evaluated. To explore the non-linear relationship, restricted cubic spline (RCS) with three knots coupled with a logistic regression model to assess the dose-response relationship between waist circumference (continuous variables) and sleep disorder. A total of 2,545 (Weighted 14,682,916.3) elderly participants with complete information were included in the analysis and 312 (Weighted 1,777,137.8) subjects met the definition of sleep disorder. Compared with participants without sleep disorder, those with sleep disorder had a higher waist circumference (100.80 cm vs. 108.96 cm, P< 0.001). The results of the multivariable adjusted logistic regression model suggested that those in quartiles 4 (≥ 75th percentile) for their waist circumference had higher odds of sleep disorder [adjusted odds ratio (AOR) = 2.75, 95% confidence interval (CI) = 1.66–4.54, P < 0.001] compared with those in quartile 1. The RCS result showed that the OR of sleep disorder and waist circumference displayed a linear relationship (P <0.001, Non-linear P = 0.642). Age and gender subgroup analysis revealed comparable relationships between waist circumference and sleep disorder among elderly individuals. Waist circumference was associated with sleep disorders in the elderly. There was a dose-response relationship between waist circumference and the likelihood of sleep disorder. Those with a larger waist circumference were more likely to have a sleep disorder than those with a smaller waist circumference.
A hybrid approach of ensemble learning and grey wolf optimizer for DNA splice junction prediction
Authors: Hamouda Eslam , Tarek Mayada
Published: September 2024

DNA splice junction classification is a crucial job in computational biology. The challenge is to predict the junction type (IE, EI, or N) from a given DNA sequence. Predicting junction type is crucial for understanding gene expression patterns, disease causes, splicing regulation, and gene structure. The location of the regions where exons are joined, and introns are removed during RNA splicing is very difficult to determine because no universal rule guides this process. This study presents a two-layer hybrid approach inspired by ensemble learning to overcome this challenge. The first layer applies the grey wolf optimizer (GWO) for feature selection. GWO’s exploration ability allows it to efficiently search a vast feature space, while its exploitation ability refines promising areas, thus leading to a more reliable feature selection. The selected features are then fed into the second layer, which employs a classification model trained on the retrieved features. Using cross-validation, the proposed method divides the DNA splice junction dataset into training and test sets, allowing for a thorough examination of the classifier’s generalization ability. The ensemble model is trained on various partitions of the training set and tested on the remaining held-out fold. This process is performed for each fold, comprehensively evaluating the classifier’s performance. We tested our method using the StatLog DNA dataset. Compared to various machine learning models for DNA splice junction prediction, the proposed GWO+SVM ensemble method achieved an accuracy of 96%. This finding suggests that the proposed ensemble hybrid approach is promising for DNA splice junction classification. The implementation code for the proposed approach is available at https://github.com/EFHamouda/DNA-splice-junction-prediction.
Perioperative PD-1/PD-L1 inhibitors for resectable non-small cell lung cancer: A meta-analysis based on randomized controlled trials
Authors: Huang Hai , Li Lianyun , Tong Ling , Luo Houfu , Luo Huijing , Zhang Qimin
Published: September 2024

Background

PD-1/PD-L1 inhibitors (PI) have shown promising results in both neoadjuvant and adjuvant therapies for resectable non-small cell lung cancer (NSCLC). However, substantial evidence from large-scale studies is still lacking for their use in the perioperative setting (neoadjuvant plus adjuvant). This meta-analysis aims to evaluate the integration of perioperative PI (PPI) with neoadjuvant chemotherapy for resectable NSCLC.

Methods

To identify appropriate randomized controlled trials (RCTs), we thoroughly explored six different databases. The primary endpoint was survival, while the secondary measures included pathological responses and adverse events (AEs).

Results

Six RCTs involving 2941 patients were included. The PPI group significantly improved overall survival (OS) (hazard ratio [HR]: 0.62 [0.51, 0.77]), event-free survival (EFS) (HR: 0.57 [0.51, 0.64]), pathological complete response (risk ratio [RR]: 5.81 [4.47, 7.57]), and major pathological response (RR: 2.60 [1.77, 3.82]). Benefits in EFS were seen across all subgroups. OS rates at 12–48 months and EFS rates at 6–48 months were higher in the PPI cohort. Furthermore, the advantages in OS and EFS increased with prolonged survival times. The PPI group also exhibited higher rates of surgery and R0 resections. However, the PPI group experienced more grade 3–5 AEs, serious AEs, and treatment discontinuations due to AEs.

Conclusions

The integration of perioperative PI with neoadjuvant chemotherapy can significantly improve survival and pathological responses for resectable NSCLC. However, the increased incidence of grade 3–5 AEs must be carefully evaluated.
Pausânias. Descrição da Grécia. Livro VII
Authors: Silva Maria de Fátima
Published: September 2024

Pausânias é o nosso único testemunho de literatura periegética e o autor de um relato precioso sobre a Grécia da época de ocupação romana (séc. II d.C.). A sua descrição é a de alguém que viajou e sintetiza o que ‘viu’, com um olhar que não é só o de um turista curioso, mas de um intelectual que dispõe de uma sólida formação cultural e de uma informação ampla, em resultado de uma recolha criteriosa de todo o tipo de fontes, orais e escritas. Para com Pausânias mantemos em aberto uma enorme dívida: a de ter salvado um lastro de monumentos, de acontecimentos históricos, de figuras e de tradições que, sem ele, se teriam em definitivo apagado da memória dos homens.
http://www.casopis-gradjevinar.hr/assets/Uploads/JCE-76-2024-7-1-3893-EN.pdf
Authors: Pekdogan Tugce
Published: September 2024

This study examined the effectiveness of the LEED green building rating system and identified performance gaps in developing countries using Türkiye as a case study. The analysis of 134 LEED Platinum V4-certified buildings in Turkiye revealed discrepancies in high-priority sites, site evaluation, building product definition and optimisation, and low-emission material credits compared with other countries. Variations in energy, atmosphere, and indoor environmental quality criteria were also noted within LEED Platinum-certified buildings in Turkiye. The study concludes that while LEED is widely embraced, local standards and contextual factors must be considered when implementing these programs.
Effect of advanced insulation materials and passive optimization strategies on interior thermal comfort of traditional houses in winter
Authors: Zhu Yiyun , Liu Lu , Sang Guochen , Cui Xiaoling
Published: September 2024

This study proposed an interior thermal comfort test to enhance the interior thermal comfort of traditional houses in the Guan Zhong region of the Shaanxi Province during winter. The study was conducted in Xiaoliu village by employing field tests and a questionnaire survey. The field tests and analysis revealed that the thermal comfort of traditional houses in this region is poor, the spatial layout of the houses is unsuitable for conserving heat, the thermal properties of the enclosure walls are inadequate, and the mode of heating is inefficient. The heat transfer parameters, heat lost and gained through fabrics, and thermal properties of nanomaterials have been used to improve the thermal comfort analysis. Combined with the local economic conditions, passive design strategies such as optimizing the spatial layout, improving the thermal insulation performance of the enclosure walls, and using solar energy were implemented. The simulation results indicate that energy consumption can be significantly reduced, and the indoor thermal comfort of traditional houses can be enhanced by reasonably dividing the indoor space, increasing the thermal insulation performance of the enclosure walls, and making better use of solar energy and natural ventilation. Therefore, to improve thermal comfort and reduce the energy load of traditional houses in the Guan Zhong region, it is necessary to adopt passive optimisation strategies.
Simulation of the process of issuing the certificate of occupancy
Authors: Obradović Dino , Ševerdija Domagoj , Has Adela
Published: September 2024

In this paper, a discrete simulation model was developed for the certificate of occupancy (CO) for certain buildings issuance process in the Republic of Croatia. The model demonstrates the multistage nature of the process, with site inspections being the most time-consuming stage and a potential bottleneck. The model also shows that senior professional associates have the highest workloads. A what-if analysis was conducted to simulate the failure of the eDozvola system and to demonstrate the significant impact of such an interruption. A cost analysis of the CO issuance process demonstrated the potential for cost savings and efficiency gains through process optimization. Thus, simulation modelling can significantly improve the CO issuance process, resulting in cost savings, increased efficiency, greater stakeholder satisfaction, and better decision-making.
Macron a megújuló energiák fejlesztése terén Latin-Amerikára koncentrál
Authors: Fernandez Saralegui Clara
Published: September 2024

Az év elején Emmanuel Macron francia elnök látogatást tett Lula da Silva brazil elnöknél, ami 2017 óta az első francia elnöki utazás Dél-Amerikába. Jair Bolsonaro kormányzása alatt több nézeteltérés is volt a francia brazil kapcsolatokban, de most a stratégiai együttműködés lehetőségét keresik a felek.
A Citgo eladása nagy veszteség Venezuelának
Authors: Fernandez Saralegui Clara
Published: September 2024

Venezuela küzdelme a CITGO Petroleum Corporation tulajdonjogáért küszöbön áll.
Influência da adição de polpa preparada sabor morango na qualidade sensorial de queijo tipo petit suisse
Authors: Do Couto Sandy Roberta , Della Testa Ana Flávia , Ferraz João Vitor , Silva Adami Lívia Maria , Cézar Isabela Christina , Dutra Mariana Borges de Lima , Coutinho Pinheiro da Rosa Fernanda
Published: September 2024

O queijo petit suisse é um queijo fresco, elaborado com leite pasteurizado, de altíssima umidade, de consistência leve, suave e cremosa. A análise sensorial é uma ferramenta utilizada na indústria alimentícia para obter informações sobre as experiências, percepções e expectativas dos consumidores, considerando estímulos visuais, olfativos, gustativos e táteis do alimento, juntamente com os fatores físicos, psicológicos, culturais, sociológicos e ambientais. Nesse cenário, o presente trabalho teve como objetivo verificar a influência da adição de polpa preparada sabor morango na aceitação sensorial, intenção de compra e coloração rosa ideal nas diferentes formulações de queijo tipo petit suisse. A amostra sem adição da polpa foi adicionada de 0,6% de aroma artificial sabor morango e as demais amostras receberam em suas formulações 7,4%, 13,8%, 24,2%, 32,4% e 42,8% de polpa preparada sabor morango. Os testes sensoriais de aceitação, intenção de compra e coloração rosa ideal foram realizados em cabines individuais sob luz branca com a presença de 120 consumidores. Com a análise dos resultados, concluiu-se que a adição da polpa preparada sabor morango influencia positivamente a qualidade sensorial do produto até certo ponto, uma vez que o excesso de polpa pode prejudicar as características sensoriais, e, consequentemente, impactar negativamente na avaliação do produto.
Dynamics of Splenic Transient Elastography in Patients With Alcohol Use Disorder
Authors: Khalid Mian B. , Blaney Hanna L. , Vittal Anusha , Yang Alexander H. , Asif Bilal A. , Kamal Natasha , Wright Elizabeth C. , Koh Chris , George David , Goldman David , Horneffer Yvonne , Diazgranados Nancy , Heller Theo
Published: September 2024

INTRODUCTION:

Splenic stiffness (SS) measurement (SSM) is an evolving noninvasive assessment to evaluate portal hypertension. Studies with respect to SSM in patients with alcohol use disorder are limited.

METHODS:

We studied patients seeking treatment for alcohol use disorder in an inpatient treatment protocol at the National Institutes of Health and parsed SSM into 3 groups based on degree of change.

RESULTS:

The improved SS group had statistically higher initial SSM and a nonstatistically increased liver stiffness measurement compared with others.

DISCUSSION:

SS is dynamic in a subset of patients immediately after alcohol cessation, and improved SS is associated with a normalization of platelet count.
Utilization of Finite Element Method for Analysis of Shoe Size Assessment Method Based on Magnetic Field Measurements
Authors:   Politechnika Warszawska, Wydział Mechatroniki, Instytut Metrologii i Inżynierii Biomedycznej, Nowak Paweł , Nowicki Michał , Gazda Piotr , Frydrych Piotr , Nowicka Natalia , Szewczyk Roman
Published: September 2024

Paper presents utilization of Finite Element Method (FEM) for analysis of usefulness of shoe size assessment method, based on magnetovision measurements. Measurement method based on disturbances of the uniform magnetic field (e.g. Earth’s magnetic field) is presented. Disturbances are caused by loose material of high magnetic permeability placed inside the tested shoe, which adapts to the insides of the shoe. The disturbed magnetic field is measured by the matrix of magnetometers. The values of magnetic field are an input into inverse transformation algorithm which fits the position of matrix sensors into the reference (obtained by FEM) distribution of magnetic field. Based on the fitted parameters of sensors matrix a ratio between the measured and reference shoe size was determined. A FEM-based forward transformation is presented, which allows for generation of three-dimensional array of magnetic field distribution. Initial tests of inverse transformation were conducted successfully. Next steps consisted of tests of inverse transformation method with an inclusion of the typical measurement noise. A FEM-based forward transformation was conducted of a modified shoe model (including simplified screw model). Inverse transformation was conducted but both influence of measurement noise, as well as the presence of additional high permeability material, resulted that the presented shoe size assessment method is not suitable for practical implementation.