bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Fasilitas Perpustakaan terhadap Minat Baca Siswa di Perpustakaan MAN Curup Rejang Lebong
Authors: Rizkyantha Okky , Tamalah Dipi , Iswanto Rahmat
Published: January 2023

The purpose of this study was to determine library facilities, the level of interest in reading and the effect of limited library facilities on students' reading interest at MAN Curup Rejang Lebong. This study used a quantitative research approach which showed the effect of variable X on variable Y. The population in this study were 541 students of MAN Curup Rejang Lebong. The sample in this study was 54 people or 10%. Data collection techniques used are observation, questionnaires and documentation. While technical data analysis using descriptive statistical analysis and inferential statistical analysis techniques using Simple Linear Regression. With the results of the study showing that the library facilities in Curup Rejang Lebong MAN were in the good category with a percentage rate of 79.80 percent. The reading interest level of students at MAN Curup Rejang Lebong is in the high category with a percentage rate of 79.76 percent. This can be proven by the results of simple linear regression, namely the results obtained f count> f table, namely 71.300> 4.08, then Ho is rejected and Ha is accepted. So it can be concluded that there is an influence of library facilities on students' reading interest at MAN Curup Rejang Lebong.
Koleksi Surat Kabar Langka Perpustakaan Nasional RI sebagai sumber informasi sejarah Indonesia pada masa revolusi (1949-1950): Studi Kasus Surat Kabar Berita Indonesia, Al-Djihad dan Ra’jat
Authors: Supratman Frial Ramadhan
Published: January 2023

Surat kabar merupakan salah satu koleksi perpustakaan bukan buku yang sangat penting dalam memberikan informasi. Perpustakaan Nasional Republik Indonesia merupakan perpustakaan yang memiliki koleksi surat kabar paling lengkap di Indonesia. Salah satu koleksi surat kabar yang menjadi  keunggulan dari koleksi Surat Kabar Langka Perpustakaan Nasional Republik Indonesia adalah surat kabar Indonesia masa revolusi (1949-1950). Berbagai surat kabar yang terbit pada masa revolusi memberikan banyak informasi mengenai keadaan Indonesia, termasuk kegiatan diplomasi dan perjuangan. Artikel ini membahas mengenai literasi informasi mengenai sejarah Indonesia masa revolusi. Penulis fokus untuk membahas koleksi surat kabar langka di Perpustakaan Nasional Republik Indonesia yang terbit pada masa revolusi (1949-1950).
At the crossroads of Georgian and Russian cultures
Authors:   Peoples’ Friendship University of Russia, Sinyachkin Vladimir P. , Vladimirova Tatyana E. , Khatiashvili Khatia A. ,   Tbilisi State University named after Ivane Javakhishvili
Published: January 2023

This article is devoted to a conceptual analysis of the basic values of Russian and Georgian linguistic cultures — the concept of “bread”, which is included in the repertoire of the most recurrent axiologemes of national language pictures of the world. The authors of the work come to the conclusion that the value picture of the world serves as a teleological vector for the development of culture. At the level of a descriptive essay, the work establishes a correlation between the mentality and the value level of the picture of the world. The corpus of texts (dictionary, paremiological, artistic) of the Russian and Georgian languages, in which the concept of “bread” is represented, served as an illustrative material for the analysis. Typical convergences and divergences of concepts in cognizable cultures are established. The conclusion is made about the common perception of the value of “bread”, which is based on the foundation of Christian culture.
The phenomenon of the Russian poet Pavel Vasiliev: His own among “his own” and “strangers”
Authors:   State University of Management, Krylova Natalya F. , Talalova Larissa N.
Published: January 2023

The article analyzes the literary works of the outstanding Russian Soviet poet Pavel Vassilyev, the native of the Kazakhstan hinterland, who incorporated two cultures, both the Kazakh and the Russian one. The attention is paid to the so-called ‘Russian Asiatic’ P. Vassilyev’s image, the poet is appreciated as a Eurasian author, as well as a ‘borderland literature’ / transborder poet (opposite to the settings on his bilingual background). There made the attempts to draw a parallel between the Kazakh and Russian philologists’ data, the validity of the poet’s figure for the Kazakh perceiving him as their native is illuminated. P. Vassilyev’s poetic language is also under analysis: it is the existence of the dynamic literary image which appears in the frameworks of movement, both in time and space, on contradiction of movable / moving and static ones. The specific thing of P. Vassilyev’s poetic language is the counterbalance between the active and passive, the mobile and immobile, when the non-visible action turns into an action full of energy, thus, it merely intensifies the text dynamics. That is why the poet’s key concepts are wind, horse, and river which are closely connected with dynamics. The sun as a relevant element of the Universe is also marked in Pavel Vassilyev’s poetry, the authors deal with the way of this concept manifestation by the poet within his poetic world.
Onomastic transculturality in Khamid Ismailov's novel “Mbobo”
Authors:   Moscow City Pedagogical University, Garipova Gulchira T. ,   Vladimir State University named after A.G. and N.G. Stoletovs
Published: January 2023

The article examines the specifics of structuring direct receptions and transcultural references in the artistic hierotopic project of Hamid Ismailov, in particular in the system of the onomasticon of the title in the novel “Mbobo”. The author focuses on the modern identification crisis of phenomena associated with the world-modeling strategies of the national picture of the world of polydomic writers by means of a “different” culture — lingual, figurative, mythopoetic. Researcher introduces the concept of hierotopy “image-paradigm” into the methodology of intertextual literary analysis, identifies its symbolic concenter “word” and correlates the semiotic and semantic meanings of the title of the novel and individual chapters with a number of obvious and non-obvious intertexts and metatexts — national onomastic tradition, literary tradition, socio-cultural and religious connotations, etc.
Translingual poetry by Rupi Kaur
Authors:   Peoples’ Friendship University of Russia, Kulieva Sheker A. , Shchennikova Nina V.
Published: January 2023

The article is devoted to understanding the problem of translingualism in modern English poetry. Based on the research of domestic and foreign scientists, the authors come to the conclusion that translingualism is not only the practice of switching codes and the ability of the author to create in a language that is learned for him, but also the creation of a special type of narrative, which is built on the basis of the logic of an ethnically primary culture: its patterns, archetypal substrates, key themes and motifs. The material of the article was the works of the modern Canadian writer of Indian origin Rupi Kaur, in particular, the book of poems the sun and her flowers. In the zone of special interest is the chapter “Acceleration”, devoted to the problems of immigration, the search for ontological coordinates, identity and language.
Profiles of Clinical and Liver Function Test of Hepatitis B and C Patients with Liver Cirrhosis
Authors: Watang Andreas Novaldi , Aryati Aryati , Kholili Ulfa
Published: January 2023

Highlights:1. Liver cirrhosis due to viral hepatitis is still a big problem in developing countries.2. There were no significant differences in clinical and laboratory profile results between patients with liver cirrhosis caused by hepatitis B and C.
AbstractIntroduction: Liver cirrhosis is a degenerative liver disease that ranks 14th as a global problem and has a high prevalence rate. This study aimed to determine the clinical and laboratory profile of inpatients with liver cirrhosis.Methods: Medical record data of liver cirrhosis patients at Dr. Soetomo General Academic Hospital, Surabaya, in 2018-2019, were used in this cross-sectional descriptive observational study. The results were analyzed statistically to determine the different profiles between patients with liver cirrhosis caused by hepatitis B and C.Results: 112 subjects in this study had liver cirrhosis caused by hepatitis B or C. The majority of cirrhotic patients were males over 40 years old. Melena was the most frequent complaint, and abdominal enlargement and hepatitis B virus (HBV) infection were the most common causes. Liver function tests in hepatitis B and C patients respectively showed albumin results of 2.73 g/dL (± 0.54); 2.75 g/dL (± 0.61), prothrombin time was 14.75 seconds (10.80-49.40); 14.9 seconds (11.1-19.1), direct bilirubin 1.17 mg/dL (0.9-17.05); 0.82 mg/dL (0.12-8.43), total bilirubin 2.18 mg/dL (0.28-24.9); 1.58 mg/dL (0.38-9.7), AST 50.5 U/L (16-826); 48.5 U/L (31-545), ALT 51.5 U/L (8-869); 38.5 (12-127). Subjects with hepatitis B and C had a median length of stay of 7.00 days, with an overall mean of 7.16 days. There was no significant difference in the results between patients with liver cirrhosis due to hepatitis B and C.Conclusion: There was no significant difference between patients with liver cirrhosis caused by hepatitis B and C.
Effects of Javanese Ginseng Root Extracts (Talinum triangulare W.) on Thickness of Seminiferous Tubules of Male Rats (Rattus norvegicus) Exposed by Cigarette Smoke
Authors: Nur Rifqi Misbahuddin , Ilahika Anung Putri , Andari Desy
Published: January 2023

Highlights:1. Infertility in men can be caused by smoking, the content of free radicals in cigarettes can affect male reproductive organs.2. Javanese ginseng root (Talinum triangulare w.) extract contains ginsenoside which is a natural antioxidant to reduce free radical levels inside the body.3. Javanese ginseng root (Talinum triangulare w.) extract was able to reduce free radical levels as seen from the appearance of the seminiferous tubules of male white rats exposed to cigarette smoke.
AbstractIntroduction: Cigarette smoke contains various radical chemical compounds that can increase oxidative stress, which may cause lipid peroxidation in the body and affect various different organs. This study aimed to examine the effects of Javanese ginseng root extracts (Talinum triangulare W.) on the thickness of seminiferous tubules of white male rats (Rattus norvegicus) exposed to cigarette smoke.Methods: This was an experimental study with a randomized controlled method and a post-test control group design. Post-test control group design with 15 white male rats was divided into five groups: a normal group, a control group (exposed to cigarette smoke), and three treatment groups (exposed to cigarette smoke and Javanese ginseng root extract with doses of 12.5mg, 25mg, and 50mg/200grBW, respectively) for 30 days. The seminiferous tubule thickness was observed using H&E staining under a light microscope with 200x magnification in five fields view.Results: One-way ANOVA showed that Javanese ginseng root extracts significantly affected seminiferous tubule thickness (p = 0.000). With a dose of 12.5mg/200mgBW, Javanese ginseng root extract started to show a significant effect (p = 0.000) on the thickness of the epithelium of the seminiferous tubules. The group exposed to cigarette smoke had an average thickness of seminiferous tubules of 7.92 mm, the normal group had an average thickness of 9.13 mm, and treatment groups with doses 12.5mg, 25mg, and 50mg/200gBW had an average thickness of 11.85 mm, 12.7mm, and 14.69 mm, respectively.Conclusion: Javanese ginseng root extract increased seminiferous tubule thickness in white male rats exposed to cigarette smoke.
Targeted mechanical forces enhance the effects of tumor immunotherapy by regulating immune cells in the tumor microenvironment
Authors:   Cancer Center, Department of Medical Oncology, Zhejiang Provincial People&, Zhu Pengfei ,   #x2019,   s Hospital (Affiliated People&,   #x2019,   s Hospital, Hangzhou Medical College), Hangzhou 310014, China,   Graduate School of Clinical Medicine, Bengbu Medical College, Bengbu 233000, China, Lu Hongrui ,   Cancer Center, Department of Medical Oncology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou 310014, China; Graduate School of Clinical Medicine, Bengbu Medical College, Bengbu 233000, China, Wang Mingxing ,   Cancer Center, Department of Medical Oncology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou 310014, China; Graduate School of Clinical Medicine, Bengbu Medical College, Bengbu 233000, China, Chen Ke ,   Department of Gastroenterology & Pancreatic Surgery, Zhejiang Provincial People’s Hospital, Hangzhou 310014, China, Chen Zheling ,   Cancer Center, Department of Medical Oncology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou 310014, China, Yang Liu ,   Cancer Center, Department of Medical Oncology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou 310014, China; Graduate School of Clinical Medicine, Bengbu Medical College, Bengbu 233000, China
Published: January 2023

Mechanical forces in the tumor microenvironment (TME) are associated with tumor growth, proliferation, and drug resistance. Strong mechanical forces in tumors alter the metabolism and behavior of cancer cells, thus promoting tumor progression and metastasis. Mechanical signals are transformed into biochemical signals, which activate tumorigenic signaling pathways through mechanical transduction. Cancer immunotherapy has recently made exciting progress, ushering in a new era of “chemo-free” treatments. However, immunotherapy has not achieved satisfactory results in a variety of tumors, because of the complex tumor microenvironment. Herein, we discuss the effects of mechanical forces on the tumor immune microenvironment and highlight emerging therapeutic strategies for targeting mechanical forces in immunotherapy.
METAFORA BINATANG DALAM PERIBAHASA DIALEK MELAYU DELI
Authors: Astari Delima , Panjaitan Novia Yollanda , Mulyadi Mulyadi
Published: January 2023

Berbicara mengenai peribahasa mungkin sudah tidak asing . Dalam peribahasa banyak terkandung makna dan nilai kebudayaan. Membicarakan peribahasa tidak terlepas dari metafora sebagai unsurnya. Kata metafora merupakan kelompok kata bukan dengan arti yang sebenarnya, melainkan sebagai lukisan yang berdasarkan persamaan atau perbandingan. Peneliti mengkaji penggunaan metafora hewan dalam peribahasa Melayu ini mengandung berbagai konsepsi kebudayaan yang mencerminkan kebudayaan masyarakat penggunanya.Penelitian ini membahas tentang peribahasa dalam Melayu Deli yang bersumber dari hewan menggunakan kajian semantik kognitif. Metode yang digunakan dalam penelitian ini adalah penelitian kualitatif deskriptif. Metode kualitatif merupakan prosedur penelitian yang menghasilkan data deskriptif berupa kata-kata tertulis atau lisan. Sejalan dengan pendekatan penelitian tersebut, penelitian ini bersifat deskriptif atau sinkronis. Objek kajian dalam penelitian ini adalah peribahasa dialek Melayu Deli. Data awal diperoleh dari kumpulan peribahasa Indonesia. Berdasarkan analisis yang telah dilakukan terdapat 5 kelompok penggunaan binatang dalam peribahasa Melayu Deli. Kelompok hewan meliputi kelompok burung, ikan, reptile, mamalia, amfibi, dan serangga. Konseptualisasi binatang dapat bersifat negatif dan positif.
IKLAN GOJEK BERJUDUL JANGAN SEPELEKAN KEKUATAN SEBUAH JEMPOL: ANALISIS SEMIOTIKA ROLAND BARTHES
Authors: Pramana Alfian Gilang , Suryaman Maman
Published: January 2023

Para pelaku bisnis berlomba-lomba untuk membuat iklan dengan kreativitas masing-masing melalui Yotube sebagai media sosial yang populer bagi masyarakat Indonesia.. Salah satunya yaitu Gojek yang belum lama ini menghadirkan iklan berjudul Jangan Sepelekan Kekuatan Sebuah Jempol di Youtube. Penelitian ini bertujuan menginterpretasikan pemaknaan jempol pada iklan tersebut dengan menggunakan analisis semiotika Roland Barthes. Metode penelitian yang digunakan adalah kualitatif deskriptif. Ada 18 versi iklan Gojek untuk judul Jangan Sepelekan Kekuatan Sebuah Jempol di Youtube. Hasil interpretasi iklan ini yaitu adanya pemaknaan kata jempol yang sangat luas. Dari sudut pandang tertentu jempol bisa menjadi sesuatu yang memiliki konotasi positif dan juga negatif. Melalui iklan ini, gojek berusaha mengajak penonton iklan untuk turut andil dalam menciptakan kebermaknaan jempol ke arah yang baik. Pesan inilah yang berusaha disampaikan oleh Gojek. Melalui kreativitasnya, Gojek dapat menghasilkan warna baru terhadap kebermaknaan sebuah jempol.
KECEMASAN NEUROTIK TOKOH UTAMA NOVEL HUJAN BULAN JUNI KARYA SAPARDI DJOKO DAMONO
Authors: Wildaniyah Erli , Sugiarti Sugiarti
Published: January 2023

Gangguan kecemasan terjadi karena munculnya ketakutan dan kecemasan yang berlebihan tentang berbagai keadaan yang tidak biasa, terlalu banyak memikir tentang keinginan, dan solusi untuk setiap opsi terburuk. Penelitian ini bertujuan untuk mendeskripsikan (1) bentuk kecemasan neurotik yang dialami oleh tokoh Sarwono dan (2) faktor penyebab kecemasan tokoh utama dalam novel Hujan Bulan Juni karya Sapardi Djoko Damono. Pendekatan penelitian ini adalah pendekatan psikologi sastra. Sumber data penelitian, berupa novel Hujan Bulan Juni karya Sapardi Djoko Damono. Untuk mengumpulkan data digunakan teknik kajian pustaka, teknik baca,dan teknik catat. Teknik analisis data dilakukan dengan mengidentifikasi, mengklasifikasikan,menganalisis, dan penarikan kesimpulan. Hasil penelitian menunjukkan (1) bentuk kecemasan neurotik yang dialami Sarwono sebagai tokoh utama meliputi  rasa takut dan gusar. Bentuk rasa takut dan gusar tersebut meliputi perasaan cemas, khawatir, penyangkalan, dan juga marah. Kecemasan neurotik yang dialami oleh Sarwono mengakibatkan dampak psikis seperti rasa putus asa, sedih, dan takut. (2) faktor penyebab kecemasan neurotik yang dialami tokoh utama berupa pikiran yang tidak rasional, rasa pesimistis,dan tingkat religiusitas yang rendah.
CASE STUDY OF SOYBEAN INOCULATION WITH BIOTECHNOLOGICAL PREPARATIONS
Authors: Koliada O. , Bliznjuk O. , Masalitina N. , Belinska A. , Varankina O. , Belykh I.
Published: January 2023

Soybean is a powerful biological fixer of molecular nitrogen. Increasing the intensification of nitrogen fixation of the culture is facilitated by inoculation – the settlement of the root zone with effective strains of symbiotic nodule bacteria. Bubble symbiotic bacteria fix molecular nitrogen and transform it into a form available for cultures. Also, nodule bacteria synthesize amino acids and vitamins of group B and other biologically active substances, which in general has a positive effect on the growth and development of soybeans and ensures high crop productivity. Peculiarities of the interaction of leguminous plants and nodule bacteria in field conditions depend on a number of factors, such as the genotype of plants, species composition, the number and activity of nitrogen fixers, the properties of soils, their water and temperature regimes, and the level of agricultural technology.

The effectiveness of soybean inoculation with biotechnological preparations based on nitrogen-fixing microorganisms was analyzed. In Ukraine, a number of biotechnological preparations on the basis of nodule bacteria such as Nitragin, Rhizotrophin, Rhizoaktiv, Rhizobophyte, Rhizohumin, Azotophyte, Azorchis have been created and tested. According to the results of the scientific literature analysis and the conducted research, a positive effect of biotechnological preparations  use on the formation of nodules on soybean roots and the increase in the intensity of nitrogen fixation was established. Positive changes in the indicators of the crop yield structure under the influence of inoculation were also monitored. It has been confirmed that the productivity of soybeans has increased due to the biotechnological preparations use based on symbiotic nitrogen-fixing bacteria. It has been proven that the inoculation of soybeans with biotechnological preparations is an effective measure that ensures an increase in the productivity of soybeans, an improvement in the quality of the obtained products, contributes to the intensification of the formation of nodules on the roots, and as a result, enhances the fixation of atmospheric nitrogen.
The Income of Business Snack Video Application on the Covid-19 Pandemic toward Islamic Economic Law Perspective in Bukittinggi
Authors: Wadi Fajrul , Hendri Hendri
Published: January 2023

In this research, there are two issues that are studied, firstly how is the business practice of Snack Video applications during the Covid-19 pandemic, secondly how is the perspective of Islamic economics law on the practice and income of the Snack Video application business. Researchers use the field method (field research). This research is qualitative research, then the data is described, analyzed, and discussed to answer these problems. So from the results of the study, it was found that the implementation of the Snack Video application business during the Covid-19 pandemic in Bukittinggi had there aspects, how to use the Snack Video application, how to exchange coins and become money from the Snack Video application and the motivation to use the Snack Video application was in accordance with the provisions. The Snack Video application and in accordance with the provisions of Islamic economy, which is not contrary to Islamic economy, as for cashing out the coins generated from the Snack Video application, it can be disbursed through the application. Money accepted by users is sourced from the company Joyo Technology, Pte. Ltd. and this is mutually beneficial for both parties. According to Islamic law, the contract on Snack Video application consisted of ijarah contract and juala contract which includes 4 missions to get coins that can be exchanged in the form of money. This contract is allowed so that the income earned from the Snack Video application business is included in the jaizah (allowed).
Religious Conflict and Islamic Strategies of Peacebuilding in Indonesia
Authors: Suprianto Bibi
Published: January 2023

Religious conflict is not only a matter of religion, but also a matter of human life who wants peace in life. By understanding the Islamic strategy in building peace in Indonesia, we can find conflict resolution that must be developed in life. This study argues that conflict and Islam’s strategy in building peace is a study of conflict resolution in overcoming violence and truth claims in religion. Thus, this study formulates the question of how religious conflict and Islamic strategies of peace building in Indonesia are? This study uses the library research to find sources of conflict and Islamic strategies in building peace in Indonesia. The results of this study indicate that conflict and Islamic strategies in building peace provide an overview: (1) the conflict has become a public debate about truth claims and religious violence; (2) religious culture and moderation are the strategy of Islam in building peace in Indonesia. The findings of this study indicate that conflict and Islamic strategies in building peace as conflict resolution exist in Indonesia.
Comparison of Microbiological Water Quality and Chlorine Level Between Adult Public Swimming Pool and Baby Public Swimming Pool in Klang Valley, Malaysia.
Authors: Zamzami Shahida Abd. , Naim Rosli Muhammad
Published: January 2023

Background: Swimming has become one of the favourite sports in Malaysian due to its health benefits, for essential skills. The public swimming pool is not only for an adult, but there are created for children as well.
Objective: This research aim is to assess the microbiological water quality and chlorine levels between adult and baby public swimming pools in Klang Valley.
Methodology: 21 water sample from public swimming pools, including hotel, apartment, and public swimming pool in Lembah Klang, Malaysia, was collected using sterile bottles (30 ml). Physicochemical parameters were determined using standard instruments and methods (rainbow model 78), and the colony's presence was counted using the heterotrophic plate count (HPC) method.
Result: The HPC shows that out of 21 swimming pools for adults and 21 swimming pools for babies, 19.10% did not follow the World Health Organization (WHO) HPC.
Regarding the microbiological quality (mean colony count) between baby and adult pools, there were slight differences of 0.24%. The baby pool shows a higher colony count value at 111.00±197.33 than the adult pool at 87.10 ±149.54. The independent t-test showed no significant difference, with a p-value of 0.65 (p<0.05). For chlorine level, the baby pool showed 47.6% of swimming pools following standard chlorine level, and for an adult pool, 42.90 %. Comparing between two groups offer a higher value, with chlorine at 1.58 ± 1.37 while adult pools at 1.41±1.29. The p-value for both, as analysed by an independent t-test, indicates 0.694 (p<0.05), which is not significant.
Conclusion: The study recommends improvement in the personal hygiene of swimmers, adequate disinfection of the pools and enforcement of standards by the government.
Impact of urban expansion on continental- to regional-scale warming
Authors: Chakraborty TC , Qian Yun
Published: January 2023

Urban growth is usually ignored when estimating large-scale historical climate change or for future projections since cities traditionally covered a small fraction of the terrestrial land surface. Here, by combining global satellite observations of land surface temperature with historical estimates of urban area, we demonstrate that the urban contribution to continental- to regional-scale warming has become non-negligible, especially for rapidly urbanizing regions in Asia. Consequently, expected urban expansion over the next century suggests further increased urban influence on surface climate in the future (~0.16 K for North America and Europe for high-emission scenario). Based on these results, we argue that, in line with other forms of land use/land cover change, urbanization should be explicitly included in climate change assessments. This would require further model development to incorporate dynamic urban extent and biophysics in current-generation earth system models to quantify potential urban feedbacks on the climate system across scales.
Aborted infection of HBV in human sodium taurocholate cotransporting polypeptide (hNTCP) expressed woodchuck cells
Authors: Yang Lu , Zhou Di , Martin Kächele , Wu Jun , Chen Mingfa , Lu Mengji , Yang Dongliang , Protzer Ulrike , Michael Roggendorf , Song Jingjiao
Published: January 2023

Hepatitis B virus (HBV) is a major healthy problem worldwide. Because of the narrow host range of HBV, relative research was hampered by lacking of an appropriate animal model. The natural history of woodchuck hepatitis virus (WHV) infection in woodchuck is highly similar to that of HBV infection in human. Therefore this animal may be an valuable species for establishing an in vivo and in vitro HBV infection model to evaluate HBV DNA vaccines and anti-HBV drugs. Sodium taurocholate cotransporting polypeptide (NTCP) is the functional receptor for HBV and hepatitis D virus (HDV) infection. Considering that HBV cannot successfully infect woodchuck cells possibly due to the difference of the functional domain between woodchuck NTCP (wNTCP) and human NTCP (hNTCP), therefore, we tried to make woodchuck hepatocytes susceptible to HBV infection by replacing wNTCP with hNTCP. In this study, hNTCP was introduced into the woodchuck hepatocytes by different approaches including transduction of vLentivirus-hNTCP in woodchuck hepatocytes, transfection of plentivirus-hNTCP-eGFP plasmids in woodchuck hepatocytes, as well as transduction of vAdenovirus-hNTCP-eGFP in woodchuck hepatocytes, in an attempt to make the woodchuck hepatocytes susceptible to HBV. The results showed that hNTCP was successfully introduced to the woodchuck hepatocytes. However, hNTCP-expressed woodchuck hepatocytes only sensitive to HDV infection but not HBV. This study indicating that there exist some other key factors mediate the HBV infection at early stage which have strict species specificity, and hNTCP is not the only determinant needed for HBV successful infection.
Neurological disorders throughout acute SARS-CoV2 infection: a comparative study between vaccinated and non-vaccinated patients
Authors: Cristillo Viviana , Pilotto Andrea , Piccinelli Stefano Cotti , Libri Ilenia , Locatelli Martina , Giunta Marcello , Mazzoleni Valentina , Pezzini Debora , Arici Davide , Gipponi Stefano , Cola Francesca Schiano , Cottini Elisabetta , Gamba Massimo , Magoni Mauro , Padovani Alessandro
Published: January 2023

Background
The role of vaccination on Covid-19 severity in neurological patients is still unknown. We aim at describing clinical characteristics and outcomes of breakthrough and unvaccinated Covid-19 patients hospitalized for neurological disorders.
Methods
Two hundred thirty-two Covid-19 patients were admitted to a neuro-Covid Unit form March 2021 to February 2022. Out of the total sample, 74 (32%) were full vaccinated. The prevalence, clinical characteristics and final outcomes of neurological syndromes were compared between vaccinated and unvaccinated cases.
Results
Breakthrough vaccinated cases were older (years 72.4+16.3 vs 67.0+18.9 years, p=0.029), showed higher pre-admission comorbidity score and Clinical Frailty scale score (4.46+1.6 vs 3.75+2.0, p=0.008) with no differences in terms of disease progression or mortality rate (16.2% vs 15.2%), compared to full-dose vaccinated patients.
Cox-regression analysis showed age and NEWS2 score as the variables with a significant relation to mortality between the two groups, independently from pre-morbid conditions and inflammatory response.
Conclusion
This study on breakthrough COVID-19 infection could help identify vulnerable neurological patients with higher risk of poor outcomes.
Dermokine mutations contribute to epithelial-mesenchymal transition and advanced melanoma through ERK/MAPK pathways
Authors: Imani Saber , Ma Wenqiong , Wu Zexiu , Maghsoudloo Mazaher , Ijaz Iqra , Shasaltaneh Marzieh Dehghan , Zhang Yuqin , Weng Qiao , Fu Junjiang , Wen QingLian
Published: January 2023

In the present study, the vulnerability associated with dermokine (DMKN), as a new trigger for the Epithelial-Mesenchymal Transition (EMT)-driven melanoma, was assessed based on a genome-wide genetic screening using transgenic. The results suggested a significantly higher DMKN expression in human Malignant Melanoma (MM), which was correlated with poor overall survival among melanoma patients, especially BRAF-mutated MM samples. Additionally, an in vitro knockdown of DMKN inhibited the cell proliferation, invasion, and apoptosis of MM cancer cells by activating ERK/MAPK signaling pathways and regulating STAT3 in downstream molecules. The interrogation of in vitro melanoma dataset and characterization of advanced melanoma samples revealed that DMKN downregulated the EMT-like transcriptional program through disrupting MET/EMT cortical actin, enhanced the expression of epithelial markers, and decreased that of mesenchymal markers. Whole-exome sequencing was presented with p.E69D and p.V91A DMKN mutations as novel somatic loss-of-function mutations. Further, the purposeful proof-of-principle modeled the interaction of ERK with p.E69D and p.V91A DMKN mutations in the ERK-MAPK kinase signaling that may be naturally associated with the EMT triggering during the melanomagenesis. These results provided preclinical evidence for the role of DMKN in shaping the EMT-like melanoma phenotype and introduced DMKN as a new exceptional responder to personalized MM therapy.
Invasive lionfish dispersal between shallow- and deep-water habitats within coastal Floridian waters
Authors: Airey Montana , Fogg Alexander Q. , Drew Joshua
Published: January 2023

Invasive lionfish threaten native fishes and ecosystem health of the Atlantic, Gulf of Mexico, and Caribbean communities. Controlling their spread and population growth can be difficult given their early maturity, high fecundity, a long larval dispersal period, and preference for structure. Mitigation efforts are further complicated by the existence of large and numerous, deep water refugia. Despite the potential importance of these refugia, their connection with shallow water populations and their role in recruiting pelagic larvae is poorly understood. We examined the post-settlement dispersal patterns of invasive lionfish using δ13C and δ18O stable isotope analysis on otoliths and Bayesian stock mixture analysis. We find that there is settlement within both deep- and shallow- water habitats. It is estimated that 34.5% of the shallow-water population is composed of individuals that settled in deep-water habitat and dispersed into these shallow regions post-settlement. Only 4.1% of the deep-water population is composed of individuals that settled in shallow-water habitat before dispersing. These results demonstrate a link between deep and shallow habitats within the coastal waters of Florida, with the flow of individuals from deep to shallow water being the predominate dispersal direction of post-settlement individuals. We suggest that post-settlement dispersal can contribute to the invasion of new habitat and potentially hinder shallow-water removal efforts in currently colonized areas.
Study protocol for a randomized controlled trial of Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: The PROMIZING Study
Authors: Bosma Karen J , Martin Claudio , Burns Karen E. A , Mancebo Jordi , Montero Juan Carlos Suárez , Skrobik Yoanna , Thorpe Kevin E. , Brochard Laurent , Amaral Andre Carlos Kajdacsy-Balla , Arabi Yaseen , Basmaji John , Beduneau Gaëtan , Beloncle Francois , Carteaux Guillaume , Charbonney Emmanuel , Demoule Alexandre , Dres Martin , Fanelli Vito , Geagea Anna , Goligher Ewan , Lellouche François , Maraffi Tommaso , Mercat Alain , Rodriguez Pablo , Shahin Jason , Sibley Stephanie , Spadaro Savino , Vaporidi Katerina , Wilcox Elizabeth M
Published: January 2023

Background: Proportional assist ventilation with load-adjustable gain factors (PAV+) is a mechanical ventilation mode that delivers assistance to breathe in proportion to the patient's effort. The proportional assistance, called the gain, can be adjusted by the clinician to maintain the patient's respiratory effort or workload within a normal range. Short-term and physiological benefits of this mode compared to pressure support ventilation (PSV) include better patient-ventilator synchrony and a more physiological response to changes in ventilatory demand.
Methods: The objective of this multi-centre randomized controlled trial (RCT) is to determine if, for patients with acute respiratory failure, ventilation with PAV+ will result in a shorter time to successful extubation than with PSV. This multi-centre open-label clinical trial plans to involve approximately 20 sites in several continents. Once eligibility is determined, patients must tolerate a short-term PSV trial and either (1) not meet general weaning criteria or (2) fail a 2 minute- Zero Continuous Positive Airway Pressure (CPAP) Trial using the rapid shallow breathing index, or (3) fail a spontaneous breathing trial (SBT), in this sequence. Then, participants in this study will be randomized to either PSV or PAV+ in a 1:1 ratio. PAV+ will be set according to a target of muscular pressure. The weaning process will be identical in the two arms. Time to liberation will be the primary outcome; ventilator-free days and other outcomes will be measured.
Discussion: Meta-analyses comparing PAV+ to PSV suggest PAV+ may benefit patients and decrease healthcare costs but no powered study to date has targeted the difficult to wean patient population most likely to benefit from the intervention, or used consistent timing for the implementation of PAV+. Our enrolment strategy, primary outcome measure and liberation approaches may be useful for studying mechanical ventilation and weaning and can offer important results for patients.
Development of gas standard reference material containing thirty volatile organic compounds at 1μmol/mol in nitrogen
Authors: Du Jian , Yang Jing , Tian Wen , Li Ning
Published: January 2023

A gas certified reference materials containing 30 volatile organic compounds (VOCs) including alkane, alkene and aromatic hydrocarbons in nitrogen at 1 µmol/mol level were developed using gravimetric method with four-step dilution and home-made liquid gasifying and filling apparatus. All components were analyzed using gas chromatograph with hydrogen flame ionization detector (GC-FID) and the repeatability of the analytical method was between 0.2-1.0%. Three types of cylinders were involved to test the adsorption/desorption/reaction of components on the inner wall and domestic treated cylinder were chosen for preparation. The results of within-homogeneity demonstrated that all the components remain stable above 2MPa. Furthermore, no significant change of the concentration was tested at least 16 months. Meanwhile, low temperature freezing test showed that extreme low temperature in transportation had no effect on the concentration of the gas standard material. Finally, the relative expended uncertainty (k = 2) of 30 components were evaluated using gravimetric method which were calculated as 2.2%~4.3% .
Impacts of financial development on the energy consumption in China from the perspective of poverty alleviation efficiency
Authors: Xu Jing , Weng Jinzhi , Yuan Rong
Published: January 2023

Poverty alleviation and energy saving are two major issues of sustainable development targets. Meanwhile, financial development (FD) is a powerful engine of economic growth, which is regard as a valid approach to contain the demand for energy consumption (EC). However, few studies link the three factors and explore the specific impact mechanism of poverty alleviation efficiency (PE) on the tie between FD and EC. Thus, we employ the mediation and threshold models to evaluate the influence of FD on the EC in China during 2010–2019 from the perspective of PE. We affirm that FD indirectly promotes EC through the channel of PE. The mediating effect of PE is responsible for 15.75% of the total effect of FD on the EC. Moreover, FD generates a significant threshold impact on the EC considering the change of PE. When the PE exceeds 0.524, the role of FD in promoting EC is strengthened. Ultimately, the outcome suggests policymakers need to prominent the trade-off between energy saving and poverty reduction during the fast evolution of financial system.
Are high-energy photoemission final states free-electron-like?
Authors: Strocov Vladimir , Lev Leonid , Alarab Fatima , Constantinou Procopios , Schmitt Thorsten , Stock Taylor , Nicolaï Laurent , Ocenasek Jan , Minar Jan
Published: January 2023

Three-dimensional (3D) electronic band structure is fundamental for understanding a vast diversity of physical phenomena in solid-state systems, including topological phases, interlayer interactions in van der Waals materials, dimensionality-driven phase transitions, etc. Interpretation of ARPES data in terms of 3D electron dispersions is commonly based on the free-electron approximation for the photoemission final states. Our soft-X-ray ARPES data on Ag metal reveals, however, that even at high excitation energies the final states can be a way more complex, incorporating several Bloch waves with different out-of-plane momenta. Such multiband final states manifest themselves as a complex structure and excessive broadening of the spectral peaks from 3D electron states. We analyse the origins of this phenomenon, and trace it to other materials such as Si and GaN. Our findings are essential for accurate determination of the 3D band structure over a wide range of materials and excitation energies in the ARPES experiment.
Tourism development potential and obstacle factors of traditional music in Xiangxi
Authors: Zhang Xian-yong , Xiang Hui , Wang Hua , Lu Chun-yang , Wang Ya-li , Liu Rui , Peng Bao-fa
Published: January 2023

Traditional Music (TM) is an aluable cultural resource, and research on the tourism development of which is of great significance. However, few studies have explored the tourism development potential and obstacle factors of TM. Therefore, Xiangxi, a minority area with rich TMs was selected as the research site. An evaluation index system was built, and multi factor comprehensive index method and obstacle model were used. The main conclusions were as follows: 1) The average potential of RE (resource endowment), TID (tourism industry development) and SEC (socio-economic conditions) were 0.28, 0.36 and 0.24, respectively. RE was higher in the west and lower in the east, TID was higher in the north and south and lower in the centre, while SEC was higher in the south and lower in the north; 2) The comprehensive potential was 0.29, and it was higher in the northwest and southwest and lower in other regions; 3) SEC was the main obstacle factor, and the administrative units in Xiangxi were divided into the following types: SEC obstacle, RE-TID obstacle, RE-SEC obstacle, and TID-SEC obstacle. The most urgent goal in Xiangxi was to develop economy and make full use of modern technologies to promote passenger flow. For regions with insufficient TM (eastern areas of Xiangxi), tourism development of TM should be restricted, and could turn to other resources with more obvious advantages.
WITHDRAWN: Liquids in Motion: An Investigation Into Newton's Model for Viscosity
Authors: Cook Colin
Published: January 2023

Newton’s model of viscosity in liquids employs a fixed plate and a parallel moving plate separated by a gap. The moving plate takes a conceptual liquid layer along with it and the stationary plate holds a similar liquid layer in place. This creates shear between the layers, and the differences in speeds between layers was assumed to be an arithmetic progression to zero. Experimental results and logic indicate: no zero velocity in such a system, relative speeds are actually in geometric progression, and that therefore Newton’s model is incorrect.
Dimensional analyses of a rotating cylinder and a moving plate in viscous liquids both give the dimensions of viscosity as M/(L2.T), whereas the currently accepted unit of viscosity, the poise, has dimensions M/(L.T). Therefore, the poise has been incorrectly assigned to viscosity, and existing formulas lack predictive power.
A Nomogram for the Prediction of Causative Patent Foramen Ovale in Cryptogenic Stroke
Authors: Zhang Han , Wang Shanshan , Li Shanshan , Bai Hui , Zhou Jinling , Li Lin , Wang Feng , Xu Lei , Wang Yueheng
Published: January 2023

This study aimed to determine whether left atrial (LA) enlargement was an independent risk factor for the patent foramen ovale (PFO)-attributable cryptogenic stroke (CS) and develop a nomogram to identify causative PFO. From September 2020 to September 2021, 64 patients with PFO-attributable CS and 128 age, sex, and hypertension status-matched non-stroke and non-migraine PFO patients were enrolled into the derivation cohort. The validation dataset consisted of 111 patients between October 2021 and May 2022 from the same institution. Significant characteristics of PFOs and cardiac functions in the multivariable conditional logistic regression were incorporated to develop a nomogram for recognizing high-risk PFO. PFO-attributable CS was independently correlated with LA diameter index (LADI)＞23mm/m2. The nomogram for predicting causative PFO included large right-to-left shunt, small-angle PFO and LADI＞23mm/m2. The derivation and validation groups had C-indices of 0.861 (95% CI: 0.803 – 0.919) and 0.766 (95% CI: 0.670 – 0.861), respectively. There was good consistency between the prediction and actual observation on the calibration curve. The decision curve analysis showed that the nomogram was clinically useful. PFO-attributable CS was independently correlated with LADI. The nomogram for predicting causative PFO was developed and will be useful in selecting suitable patients for PFO closure.
The severity of menopause and associated factors among middle aged women residing in Arba Minch, DHSS, Ethiopia, 2022
Authors: Misiker Begosew , kashala kefita , Misker Direslgne
Published: January 2023

Background

Menopausal symptoms are physiological symptoms that can be caused by a decrease in sex hormone levels particularly estrogen in the blood. It is among the major public health problems of middle-aged women. Particularly severe forms of menopausal symptoms are bothersome for middle-aged women. However little is known about the severity status and associated factors of menopausal symptoms among middle-aged women in the study area.

Objective

The main aim of the study was to assess the severity of menopausal symptoms and associated factors among middle-aged women residing in Arba Minch DHSS.

Methods and materials:

Community-based crossectional study was employed. A single population proportion formula was used to determine the sample size. A total of 423 study participants were recruited to conduct the study. A simple random sampling technique was used to employ study participants. Proportional sample size allocation formula was used to allocate study participants in each Kebele of Arba Minch DHSS (demographic and health surveillance site). A menopausal rating scale was used to assess the severity status of Menopausal status. The collected data were analyzed by using SPSS version 20. A descriptive analysis was made to describe the Sociodemographic characteristics of the study participants. Moreover, bivariate and multivariate logistic regressions were calculated to identify the factors associated with the severity of menopausal symptoms among middle-aged women. On bivariate logistic regression variables with p value < 0.25 were eligible for multivariate logistic regression. Variables with a p-value of less than 0.05 are considered statistically significant.

Result

The present study revealed that the prevalence of menopausal symptoms was 88.1%. According to the Menopausal rating scale, 91.2% of the study participants were Asymptomatic, 6.6% of them were mild in severity, 1.2% of them were moderate and the remaining one individual was a severe menopausal symptom. The most severe menopausal symptom was the sexual problem. The factors that have a significant association with the severity of menopausal symptoms were Age with AOR [0.22(0.59–0.87)] and history of chronic disease with AOR [2.334(1.4–24.1)].
Conclusion and recommendation: Generally the prevalence of menopausal symptoms among middle-aged women was high. Asymptomatic and mild forms are the dominant severity forms of menopausal symptoms. Age and history of chronic diseases have a significant association with the severity of menopause. The government, researchers, and stakeholders are recommended to be concerned about this neglected issue.