bluuebunny/crossref_metadata_2025 huggingface dataset:
Simultaneous laser obliteration of recurrent veins and Baker’s cyst: indications, technique, results of treatment
Authors: Chernookov A. I. , Kuznetsov M. R. , Korobova N. Yu. , Kandyba S. I. , Atayan A. A. , Ramazanov A. A. , Belykh E. N. , Nikolaev A. M. , Pshmakhova A. Z.
Published: May 2023

Introduction. The wide prevalence of varicose veins of the lower extremities and relapses of this disease causes a frequent combination of this pathology with other surgical and traumatological diseases. The expediency of using simultaneous operations is manifested in their obvious economic advantages.

Objective. To substantiate the expediency and effectiveness of simultaneous laser thermal obliteration of recurrent veins of the lower extremities and Baker’s cyst.

Materials and methods. 9 patients with recurrent varicose veins and Baker’s cyst were operated on. Of these, there were 7 (77.8%) women and 2 (22.2%) men, the average age was 52.8 ± 0.2 years. The average duration of the incidence of varicose veins was 14.1 ± 0.3 years, Baker’s cyst – 3.5 ± 0.1 years. As planned, patients underwent simultaneous laser endovenous coagulation of recurrent veins and intracavitary thermal obliteration of Baker’s cyst.

Results. There were no complications, the duration of operations was 40.3 ± 0.4 minutes. The intensity of the pain syndrome in 6–8 hours after surgery was 4.1 ± 0.2 points. On the 10th day, no pain was observed in any patient. The duration of pain was 7.8 ± 0.4 days. Long-term results were studied 12–16 months after completion of treatment in 9 (100%) patients. Recurrent varicose veins were not detected. In 8 (88.9%) patients, complete obliteration of Baker’s cyst was established.

Conclusions. Reliable obliteration of Baker’s cyst and recurrent varicose veins, 100% technical success, disappearance of clinical symptoms of this pathology, absence of relapses of both diseases in 8 (88.9%) patients after 12-16 months indicates high efficiency and indisputable prospects of such an approach to the treatment of this category of patients. However, the study is based on a small number of observations, so further accumulation of experience is required to generalize the results of the study.
Chronic compartment-syndrome of the lower limb: modern strategies for diagnosis and treatment
Authors: Katorkin S. E. , Kushnarchuk M. Y.
Published: May 2023

A review of the literature is presented, including data on the incidence, pathophysiology, and clinical picture of patients with chronic compartment syndrome (CCS) of the lower extremities. Chronic exercise compartment syndrome (CECS) is characterized by pain with repetitive exertion and increased intracompartmental pressure affecting the lower extremities in physically active patients. In severe chronic venous insufficiency of the lower extremities, chronic venous compartment syndrome (CVCS) develops, which is fundamentally different from previously known clinical pictures. Progressive dermatolipofasciosclerosis and cicatricial destruction of the fascia of the leg in patients with C4b-C6 clinical classes according to CEAP affect the pressure in the muscle-fascial compartments at each step. In severe cases, this leads to significant changes in the muscles, accompanied by chronic ischemia associated with necrosis and glycogen deficiency. The analysis of various diagnostic methods, conservative treatment and methods for performing surgical decompression of the CCS was carried out. The lack of a clear pathophysiology for CECS and CVCS complicates the diagnosis and treatment of this condition. Diagnosis of calf CCS is still based on pressure testing in the musculofascial compartments of the calf using the Pedowitz criteria, however standard procedures for this, including patient position, static or dynamic movements, muscles and equipment tested, are not agreed upon. In patients with CCS, if conservative treatment is ineffective, fasciotomy of the affected parts of the lower leg is the method of choice. Various techniques for fasciotomy of the lower leg include the traditional open fasciotomy, the semi-closed technique with one or more incisions, the minimally invasive technique using endoscopic compartment release, and the use of ultrasound guidance. Fasciectomy of the lower leg to correct CVCS is performed mainly for recurrence of trophic ulcers after shave therapy, severe calcification of the lower leg tissues and for the treatment of deep transfascial necrosis. Randomized, blinded, controlled trials are needed to further expand our knowledge of the diagnosis and treatment of CCS.
Experience in complex therapy of lower limb trophic ulcers of venous and diabetic origin
Authors: Burleva E. P. , Babushkina J. V. , Peshkov A. V. , Tyurin S. A.
Published: May 2023

Trophic ulcers (TU) associated with venous circulation pathology or diabetes mellitus are considered chronic wounds with all the attributes of the complex extracellular matrix (ECM) reorganization and tissue remodelling of the edges and bed of these wounds. It was therefore determined that only a comprehensive step-wise approach to the treatment of TU can produce a stable clinical result. The article presents the experience of comprehensive management of venous and diabetic TUs. Three clinical cases of management of patients with lower limb TUs are described. The treatment of patients was planned taking into account the accepted algorithms for the management of TU associated venous circulation pathology or diabetes mellitus. The topical therapy included advanced wound coverings. The choice of dressing was determined by the clinical course of wound process. Alginate dressings were used on stages I and II wounds; hydrocolloid dressings were used on stages II and III wounds. Effects resulting from treatment included almost complete healing or readiness of a TU for skin grafting. The topical therapy of venous and diabetic TUs is part of the comprehensive treatment. During phase 1 wound process, the topical drugs should have antimicrobial, necrolytic, draining, osmotic and analgesic action. During phase 2, the granulation tissue should be induced and the balanced moist environment should be created to promote tissue regeneration. The wound coverings specified in the above clinical examples are fully consistent with the principles of the TIME concept, their ease of use and comfort for the patient are pointed out.
GUIA DETALHADO PARA MONTAGEM PRÓPRIA DE IMPRESSORAS 3D
Authors: Pereira Mateus , Quero Reverson , de Jesus Dosil , Bonacin Juliano
Published: May 2023

DETAILED GUIDE TO OWN ASSEMBLY OF 3D PRINTERS. In recent years, there has been an increase in the use of 3D printing for the manufacture of three-dimensional objects. Thus, it is clear that 3D printers have presented as a tool with high potential for applications in several fields, including chemistry. However, despite its popularity, it is notable that some 3D printers have a relatively high cost, in addition to not favoring optimizations or repairs, making users dependent on the manufacturers of such tools. Therefore, this article aims to present, particularly to the chemistry community, a detailed guide for assembling a low-cost FDM-type 3D printer with good performance. Consequently, we hope that this guide can contribute to increasing the 3D printing popularization in the field of chemistry because of the various possibilities of applications in this area.
Does Widespread Use of Hydroxychloroquine Reduce the Transmissibility
of SARS-CoV-2 / COVID-19? An Ecological Correlational Study
Authors: Souza Neves Fabricio
Published: May 2023

Background:

At the beginning of the coronavirus disease (COVID-19) pandemic, hydroxychloroquine
(HCQ) was widely used as a possible antiviral agent. Current knowledge indicates
that HCQ has little or no effect on individual clinical outcomes of COVID-19, but populational effects
on disease transmissibility are still unknown.

Objective:

This study investigates the hypothesis that massive HCQ consumption by a population may
contribute to reducing the transmissibility of SARS-CoV-2 and COVID-19 spread by reducing the
viral load of infected individuals.

Methods:

Public database of seven states from Brazil in 2020 were assessed, before the start of
COVID-19 vaccination. The daily values of the COVID-19 effective reproduction number (Rt) were
obtained. Associations between Rt values and the proposed predictor variables (prevalence of COVID-
19 as a marker of collective immunity; social isolation indices; consumption of HCQ) were tested using
multiple linear regression analysis.

Results:

In all seven states, consumption of HCQ was a significant negative predictor of Rt (β ranged
from -0.295 to -0.502, p = 0.001). Furthermore, the mean derivative of Rt during the declining period
of the COVID-19 incidence (the mean rate of variation) was also significantly negatively related to the
mean HCQ consumption in that period (R2 = 0.895; β = -0.783; p = 0.011), meaning that the higher the
HCQ consumption, the faster the decline of COVID-19 Rt. It suggests a dose-response phenomenon
and a causal relationship in this association.

Conclusion:

The results of this study are compatible with the hypothesis that HCQ has small but significant
in vivo antiviral effects that are able to reduce SARS-CoV-2 transmissibility at the populational
level.
Acciones para el mejoramiento genético de la raza bovina criolla Sanmartinero
Authors: Rosero Alpala Jaime Aníbal , Burgos Paz William Orlando , Flórez Díaz Hernando , Bejarano Garavito Diego Hernán , Onofre Rodríguez Héctor Guillermo
Published: May 2023

A través de las propuestas del plan de fomento, muchos ganaderos han reconocido las bondades y los atributos de las razas bovinas criollas para la producción de carne y leche en el país. Una de estas razas es el Sanmartinero (sm), la cual se destaca por su fertilidad y adaptación a las condiciones del piedemonte y altillanura orinoquense. Dichos atributos han servido de pauta en los procesos de monitoreo de parámetros reproductivos y adaptativos en los cuales se enfocan las estrategias para el mejoramiento genético de la raza sm. En la actualidad, productores del piedemonte y la altillanura y el núcleo de mejoramiento genético en el Centro de Investigación Carimagua conforman una red para uso y monitoreo de la raza, dando lugar a la consolidación de acciones como el desarrollo de la cuarta edición de las pruebas de desempeño en pastoreo de toretes Sanmartinero en el Centro de Investigación La Libertad.
Cattle productivity and carbon stock in silvopastoral systems with Leucaena in the colombian dry caribbean
Authors: Mojica Rodríguez José Edwin , Rivera Rojas Milton , Lombo Ortiz Darwin Fabián , Zambrano Ortiz Juan Ricardo , Arias Rojas Jaime Andrés
Published: May 2023

Dual-purpose cattle systems in the Cesar Valley microregion are based on grazing for grasses and grasslands. In the region, the grass Colosuana (Bothriochloa pertusa) is the predominant grass that is usually associated with low milk yield in dual-purpose cows. The integration of shrubs and trees for different purposes in grazing areas is still occasionally adopted by farmers.
Evaluación en campo de PGPRs en el rendimiento de semilla súper - élite de batata (Ipomoea batatas)
Authors: Pérez Pazos Jazmín Vanessa , Sánchez López Diana Beatriz
Published: May 2023

La batata o camote es el tercer cultivo de raíces y tubérculos de importancia a nivel mundial, por su alto contenido de fibra, minerales, vitaminas y antioxidantes, se ha convertido en un producto de exportación (1), demandando la búsqueda de mejores condiciones para su cultivo. Uno de los enfoques en nutrición vegetal es la búsqueda de microorganismos promotores de crecimiento como alternativa al uso de fertilizantes de síntesis química (2), sin embargo existen aún limitantes para su uso como biofertilizantes ya que esta tecnología no puede competir con los fertilizantes de origen químico (3), por tanto el nuevo enfoque es evaluar el uso de estos microorganismos para la reducción de la fertilización química y para obtener resultados que puedan ser extrapolados a nivel comercial, se escalan a nivel de campo.
Descripción morfológica y caracterización de daños de Eurysthea sordida (Erichson) (Coleoptera: Cerambycidae) en Alnus acuminata Kunth (Betulaceae) para el valle del Mantaro, región de Junín, Perú
Authors: Baltazar Castañeda Hernán , Baltazar Sedano Danilo , Baltazar Sedano Neddy , Blanco Arroyo Joan , Quispe Zarate Sthephany Estela
Published: May 2023

Eurysthea sordida (Erichson) (Coleoptera: Cerambycidae) es un coleóptero de distribución tropical en Sudamérica que ocasiona daño de importancia económica en Alnus acuminata Kunth en el valle del Mantaro, región de Junín, Perú. En la región, no hay un estudio completo como el ciclo de vida y el daño que ocasiona a Alnus acuminata. El objetivo de esta investigación es estudiar la morfología de los estadios biológicos de E. sordida recolectados en A. acuminata, así como caracterizar su daño. Para esto, se midió la longitud total (L) y el ancho (A) de huevos, larvas, pupas y adultos de E. sordida, así como el diámetro de las perforaciones en corteza y albura de A. acuminata. Adicionalmente, se realizó la descripción morfológica completa de los estadios biológicos de E. sordida para confirmar su identificación taxonómica y la descripción morfológica completa de los estados de huevo, larva, pupa y adulto de E. sordida. Se observaron seis estadios larvales con los siguientes parámetros, i (2,518 ± 0,421 mm), ii (6,228 ± 1,858 mm), iii (15,961 ± 2,752 mm), iv (23,048 ± 1,581 mm), v (28,301 ± 1,170 mm) y vi (33,055 ± 1,412 mm). Todos los ejemplares de A. acuminata evaluados resultaron atacados por individuos de E. sordida, mostrando daños leves hasta muy severos desde la base hasta el fuste medio, en la corteza, el cámbium y la albura. Esta investigación es el primer reporte de los estadios biológicos de E. sordida y sobre los daños a la corteza y la albura de A. acuminata para el valle del Mantaro.
Health Information and Misinformation: A Framework to Guide Research and Practice
Authors: Fridman Ilona , Johnson Skyler , Elston Lafata Jennifer
Published: May 2023

When facing a health decision, people tend to seek and access web-based information and other resources. Unfortunately, this exposes them to a substantial volume of misinformation. Misinformation, when combined with growing public distrust of science and trust in alternative medicine, may motivate people to make suboptimal choices that lead to harmful health outcomes and threaten public safety. Identifying harmful misinformation is complicated. Current definitions of misinformation either have limited capacity to define harmful health misinformation inclusively or present a complex framework with information characteristics that users cannot easily evaluate. Building on previous taxonomies and definitions, we propose an information evaluation framework that focuses on defining different shapes and forms of harmful health misinformation. The framework aims to help health information users, including researchers, clinicians, policy makers, and lay individuals, to detect misinformation that threatens truly informed health decisions.
The Role of Novel Digital Clinical Tools in the Screening or Diagnosis of Obstructive Sleep Apnea: Systematic Review
Authors: Duarte Miguel , Pereira-Rodrigues Pedro , Ferreira-Santos Daniela
Published: May 2023

Background

Digital clinical tools are a new technology that can be used in the screening or diagnosis of obstructive sleep apnea (OSA), notwithstanding the crucial role of polysomnography, the gold standard.

Objective

This study aimed to identify, gather, and analyze the most accurate digital tools and smartphone-based health platforms used for OSA screening or diagnosis in the adult population.

Methods

We performed a comprehensive literature search of PubMed, Scopus, and Web of Science databases for studies evaluating the validity of digital tools in OSA screening or diagnosis until November 2022. The risk of bias was assessed using the Joanna Briggs Institute critical appraisal tool for diagnostic test accuracy studies. The sensitivity, specificity, and area under the curve (AUC) were used as discrimination measures.

Results

We retrieved 1714 articles, 41 (2.39%) of which were included in the study. From these 41 articles, we found 7 (17%) smartphone-based tools, 10 (24%) wearables, 11 (27%) bed or mattress sensors, 5 (12%) nasal airflow devices, and 8 (20%) other sensors that did not fit the previous categories. Only 8 (20%) of the 41 studies performed external validation of the developed tool. Of these, the highest reported values for AUC, sensitivity, and specificity were 0.99, 96%, and 92%, respectively, for a clinical cutoff of apnea-hypopnea index (AHI)≥30. These values correspond to a noncontact audio recorder that records sleep sounds, which are then analyzed by a deep learning technique that automatically detects sleep apnea events, calculates the AHI, and identifies OSA. Looking at the studies that only internally validated their models, the work that reported the highest accuracy measures showed AUC, sensitivity, and specificity values of 1.00, 100%, and 96%, respectively, for a clinical cutoff AHI≥30. It uses the Sonomat—a foam mattress that, aside from recording breath sounds, has pressure sensors that generate voltage when deformed, thus detecting respiratory movements, and uses it to classify OSA events.

Conclusions

These clinical tools presented promising results with high discrimination measures (best results reached AUC>0.99). However, there is still a need for quality studies comparing the developed tools with the gold standard and validating them in external populations and other environments before they can be used in clinical settings.

Trial Registration

PROSPERO CRD42023387748; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=387748
Technology-Based Music Interventions to Reduce Anxiety and Pain Among Patients Undergoing Surgery or Procedures: Systematic Review of the Literature (Preprint)
Authors: Park Sunghee , Lee Sohye , Howard Sheri , Yi Jeeseon
Published: May 2023

BACKGROUND

Hospitalized patients undergoing surgery or procedures may experience negative symptoms. Music is a nonpharmacological complementary approach and is used as an intervention to reduce anxiety, stress, and pain in these patients. Recently, music has been used conveniently in clinical situations with technology devices, and the mode of providing music is an important factor in technology-based music interventions. However, many reviews have focused only on the effectiveness of music interventions.

OBJECTIVE

We aimed to review randomized controlled trials (RCTs) of technology-based music interventions for reducing anxiety and pain among patients undergoing surgery or procedures. We examined the clinical situation, devices used, delivery methods, and effectiveness of technology-based music interventions in primary articles.

METHODS

The search was performed in the following 5 electronic databases: PubMed, MEDLINE (OvidSP), CINAHL complete, PSYCINFO, and Embase. This systematic review focused on technology-based music interventions. The following articles were included: (1) RCTs, (2) studies using interactive technology (eg, smartphones, mHealth, tablets, applications, and virtual reality), (3) empirical studies reporting pain and anxiety outcomes, and (4) English articles published from 2018 to 2023 (as of January 18, 2023). The risk of bias was assessed using the Cochrane Risk of Bias tool version 2.

RESULTS

Among 292 studies identified, 21 met the inclusion criteria and were included. Of these studies, 9 reported that anxiety scores decreased after music interventions and 7 reported that pain could be decreased before, during, and after procedures. The methodology of the music intervention was important to the results on anxiety and pain in the clinical trials. More than 50% (13/21, 62%) of the studies included in this review allowed participants to select themes themselves. However, it was difficult to distinguish differences in effects depending on the device or software used for the music interventions.

CONCLUSIONS

Technology-based music interventions could help reduce anxiety and pain among patients undergoing surgery or procedures. The findings of this review could help medical teams to choose a practical methodology for music interventions. Future studies should examine the effects of advanced technology-based music interventions using smart devices and software that promote interactions between medical staff and patients.
Use Patterns of Smartphone Apps and Wearable Devices Supporting Physical Activity and Exercise: a large-scale cross-sectional survey (Preprint)
Authors: Oba Takeyuki , Takano Keisuke , Katahira Kentaro , Kimura Kenta
Published: May 2023

BACKGROUND

Physical inactivity is a global health issue, and mobile health (mHealth) applications (apps) are expected to play an important role in promoting physical activity. Empirical studies have demonstrated the efficacy and efficiency of app-based interventions, and an increasing number of apps with more functions and richer content have been released in markets. Regardless of the success of mHealth apps, there are important evidence gaps in the literature; that is, it is largely unknown who uses what app functions and which functions are associated with physical activity

OBJECTIVE

To investigate the usage patterns of apps and wearables supporting physical activity and exercise in a Japanese-speaking community sample.

METHODS

We recruited N = 20,573 online panels who completed questionnaires concerning demographics, regular physical activity levels, and use of apps and wearables supporting physical activity. Participants who indicated that they were using a PA app or wearable were presented with a list of app functions (e.g., sensor information, goal setting, journaling, and reward), among which they selected any functions in use.

RESULTS

Approximately a quarter of the sample (n = 4,465) were identified as app users who showed similar demographic characteristics documented in the literature; that is, compared with non-app users, app users are younger (OR = 0.64, 95%CI [0.56, 0.73]), more likely to be men (OR = 0.83, 95%CI [0.76, 0.89]), have larger BMI scores (OR = 1.02, 95%CI [1.01, 1.03]), have higher levels of education (university or above; OR = 1.49, 95%CI [1.16, 1.94]), more likely to have a child (OR = 1.15, 95%CI [1.04, 1.26]) and job (OR = 1.26, 95%CI [1.16, 1.38]), and have a higher household income (OR = 1.40, 95%CI [1.21, 1.61]). Our results revealed unique associations between demographic variables and specific app functions. For example, sensor information, journaling, and GPS were more frequently used by men than women (ORs < 0.84); reward was more preferred by women (OR = 1.26, 95%CI [1.02, 1.56]). Another important finding is that people typically use two different functions within an app (IQR: 1-4 functions), and the most common pattern was to use sensor information (i.e., self-monitoring) and one other function such as goal setting or reminders.

CONCLUSIONS

Regardless of the current trend of app development toward multifunctionality, our findings highlight the importance of app simplicity. A set of two functions (more precisely, self-monitoring and one other function) might be the minimum that can be accepted by most users. In addition, the identified individual differences will help developers and stakeholders pave the way for the personalization of app functions.

CLINICALTRIAL
The Effect Of Flash-Based Interactive Learning Multimedia On The Thematic Learning Outcomes Of Grade 5 Students In Elementary School
Authors: Dewi Candra
Published: May 2023

This study aims to determine the effect of flash-based interactive multimedia learning on the fifth-grade elementary school students' thematic integrative learning outcomes. The study is a quantitative study with a True Experimental Design type of posttest-only control design. The population was 180 fifth-grade students, with 40 fifth-grade students chosen as samples using cluster sampling. The data collection used multiple-choice questions to measure the results of integrative thematic learning of the experimental and control class. The hypothesis test used is t-test. The results of the t-test analysis show that flash-based interactive multimedia learning affects the integrative thematic learning outcomes of fifth-grade elementary school students
Analisis Efektivitas Penggunaan E-Modul Berbasis Aplikasi Flipbook Pada Pembelajaran Tematik Di SD
Authors: Putri Kumalasani Maharani , Eilmelda Yenny
Published: May 2023

This study aimed to describe the effectiveness of using flipbook-based E-modules in thematic learning for fourth graders at SDN Girimoyo 02, Malang Regency. The study’s research method involves questionnaires and tests, students’ and teachers’ questionnaire responses, expert validation questionnaire results, and post-test and pre-test results. Based on the results of the study, the students’ questionnaire response was 92.85%, the teachers’ was 99%, the experts’ validation was 78%, the media validation questionnaire was 91%, the teacher questionnaire responses showed 99%, and the student questionnaire response was 93, 85. Based on these results, the E-module is categorized as valid and appropriate to use in learning activities, and the students’ cognitive result on the pre-test was 47.78, and the post-test was 83.34. Based on the results of the pre-test and post-test scores, it showed an increase, and the results of the analysis of the validation results and the responses of students and teachers showed that the E-module was effective by showing success in thematic learning, so that students understand the material well
Pengembangan Media JESSTAR Sebagai Media Pembelajaran Tematik Tema 9 Kelas VI SD
Authors: Al Arif Hidayatullah Putunda , Wayan Widana I , Ketut Suar Adnyana I
Published: May 2023

The implementation of learning in elementary schools applies thematic learning. Nevertheless, in reality, the learning process has not run optimally. It is because linkages among materials are not optimal, and there is no particular learning media for thematic learning. One of the efforts to optimize thematic learning is to develop thematic learning media. This study aims to develop JESSTAR media for thematic learning of theme 9 grade VI SD and test the learning media's feasibility. This study is developmental research in the field of education. JESSTAR media development uses the ADDIE development model (analysis, design, development, implementation, evaluation). The study was carried out at SD Negeri 1 Asahduren. The data collection method used is observation, questionnaire, and interview. The data analyzed in this research is a descriptive qualitative analysis to process data from the result of expert review and a quantitative descriptive analysis to process data on product validity and practicality test as indicators of media feasibility. The validity test results of media experts, material experts, and learning designs obtained the percentage level of validity of 95.00%, 90.67%, and 96.00%, respectively. If it is converted, then everything is in the excellent category. The results of the practicality test for teachers, small group trial, and large group trial obtained the percentage practicality level of 92.38%, 94,83%, and 93.73% respectively. If it is converted, then everything is in the excellent category. Based on the results of validity tests by experts and results of practicality tests by practitioners (teachers) and students, it can be seen that JESSTAR media is in the excellent category. Thus, it can be concluded that the JESSTAR media is suitable for use as a learning media for theme 9 in grade VI elementary schools
Barreras a la innovación: una revisión sistemática de la literatura
Authors: Ordoñez-Gutiérrez Ángela Viviana , Méndez-Morales Alberto , Herrera Milton M.
Published: May 2023

Existen múltiples barreras para que las empresas realicen efectivamente procesos de innovación. Estas barreras, según el Manual de Oslo, se agrupan en financieras, de conocimiento y de mercado. Sin embargo, en años recientes la literatura ha mostrado que, además de estas tipologías de barreras, existen otras que también impiden a las compañías alcanzar innovaciones exitosas. En este documento se realizó una revisión sistemática de la literatura para publicaciones en Scopus entre 2019 y 2022, y que tuvo como principal objetivo entender cuáles son las tendencias en investigación frente a las barreras en innovación en los últimos años, especialmente para la literatura en inglés. Los resultados mostraron que la visión tradicional de las barreras a la innovación está evolucionando desde la lógica del Manual de Oslo hacia otra en donde se genera una forma más incluyente de dichas barreras y en la que se demuestra que no solo la innovación tecnológica, sino también las innovaciones ambientales y sociales, se ven afectadas por dichas barreras. Adicionalmente, se encontró que las pequeñas y jóvenes empresas, así como las que operan en países en vía de desarrollo, son las que tienen una mayor percepción de enfrentar barreras a la innovación. Este artículo contribuye especialmente a los tomadores de decisiones y a los investigadores que buscan plantear soluciones para que las empresas se sobrepongan a las barreras a la innovación.
Revisión de la optimización de Bess en sistemas de potencia
Authors: Mendoza Osorio Diego
Published: May 2023

La creciente penetración de recursos distribuidos ha impuesto desafíos en el análisis y operación de sistemas de potencia, principalmente debido a incertidumbres en los recursos primarios. En la última década, la implementación de sistemas de almacenamiento por baterías en redes eléctricas ha captado el interés en la investigación, ya que los resultados han demostrado efectos positivos cuando se despliegan óptimamente. En este trabajo se presenta una revisión de la optimización de sistemas de almacenamiento por baterías en sistemas de potencia. Pare ello se procedió, primero, a mostrar el contexto en el cual se implementan los sistemas de baterías, su marco de operación, las tecnologías y las bases de optimización. Luego, fueron detallados la formulación y el marco de optimización de algunos de los problemas de optimización encontrados en literatura reciente. Posteriormente se presentó una revisión de las técnicas de optimización implementadas o propuestas recientemente y una explicación básica de las técnicas más recurrentes. Finalmente, se discutieron los resultados de la revisión. Se obtuvo como resultados que los problemas de optimización con sistemas de almacenamiento por baterías son un tema de tendencia para la investigación, en el que se han propuesto diversas formulaciones para el análisis en estado estacionario y transitorio, en problemas multiperiodo que incluyen la estocasticidad y formulaciones multiobjetivo. Adicionalmente, se encontró que el uso de técnicas metaheurísticas es dominante en el análisis de problemas complejos, multivariados y multiobjetivo, mientras que la implementación de relajaciones, simplificaciones, linealizaciones y la adaptación mono-objetivo ha permitido el uso de técnicas más eficientes y exactas. La hibridación de técnicas metaheurísticas ha sido un tema relevante para la investigación que ha mostrado mejorías en los resultados en términos de eficiencia y calidad de las soluciones.
Targeting Cancer Cell Signaling Using Precision Oncology Towards a Holistic Approach to Cancer Therapeutics
Authors: Kumar Manish
Published: May 2023

Cancer is a complex and multifaceted disease having a number of
composite problems to be considered including cancer immune evasion,
therapy resistance, and recurrence for prevention and cure.
Fundamentally it remains a genetic disease as diverse aspects of the
complexity of tumor growth and cancer development relate to its genetic
machinery and requires addressing the problems at the level of genome
and epigenome. Presumably, the mutational changes occurring in the
regulatory genes responsible for maintaining optimal cell growth,
proliferation, and differentiation gradually lead to cancer progression
and metastasis. Importantly, patients with the same cancer types respond
differently to cancer therapies, indicating the need for a
patient-specific treatment option for cancer cure. Precision oncology is
the field of cancer research that focuses on the genetic profiling of
individual tumors to identify targetable alterations involved in cancer
development for custom-tailored personalized treatment of the disease.
It is to rely upon the genomic study of cancer cells to get a clear
picture of the prognosis and pathways involved in disease progression
and to look for the means to selectively target them to ensure effective
treatment of this deadly disease. Thus, precision oncology combines
cancer diagnosis and prognosis followed by designing a treatment regimen
for precise treatment of cancer at different stages and times. This
article aims to briefly explain the foundations and frontiers of
precision oncology in the context of technological advances being made
in this direction to assess its scope and importance in the realization
of a proper cure for cancer.
Cardiovascular and Renal Benefits of Novel Diabetes Drugs by Baseline Cardiovascular Risk: A Systematic Review, Meta-analysis, and Meta-regression
Authors: Rodriguez-Valadez José M. , Tahsin Malak , Fleischmann Kirsten E. , Masharani Umesh , Yeboah Joseph , Park Meyeon , Li Lihua , Weber Ellerie , Li Yan , Berkalieva Asem , Max Wendy , Hunink M.G. Myriam , Ferket Bart S.
Published: May 2023

BACKGROUND

Eligibility for glucagon-like peptide 1 receptor agonists (GLP-1RA) and sodium–glucose cotransporter 2 inhibitors (SGLT2i) has been expanded to patients with diabetes at lower cardiovascular risk, but whether treatment benefits differ by risk levels is not clear.

PURPOSE

To investigate whether patients with varying risks differ in cardiovascular and renal benefits from GLP-1RA and SGLT2i with use of meta-analysis and meta-regression.

DATA SOURCES

We performed a systematic review using PubMed through 7 November 2022.

STUDY SELECTION

We included reports of GLP-1RA and SGLT2i confirmatory randomized trials in adult patients with safety or efficacy end point data.

DATA EXTRACTION

Hazard ratio (HR) and event rate data were extracted for mortality, cardiovascular, and renal outcomes.

DATA SYNTHESIS

We analyzed 9 GLP-1RA and 13 SGLT2i trials comprising 154,649 patients. Summary HRs were significant for cardiovascular mortality (GLP-1RA 0.87 and SGLT2i 0.86), major adverse cardiovascular events (0.87 and 0.88), heart failure (0.89 and 0.70), and renal (0.84 and 0.65) outcomes. For stroke, efficacy was significant for GLP-1RA (0.84) but not for SGLT2i (0.92). Associations between control arm cardiovascular mortality rates and HRs were nonsignificant. Five-year absolute risk reductions (0.80–4.25%) increased to 11.6% for heart failure in SGLT2i trials in patients with high risk (Pslope < 0.001). For GLP1-RAs, associations were nonsignificant.

LIMITATIONS

Analyses were limited by lack of patient-level data, consistency in end point definitions, and variation in cardiovascular mortality rates for GLP-1RA trials.

CONCLUSIONS

Relative effects of novel diabetes drugs are preserved across baseline cardiovascular risk, whereas absolute benefits increase at higher risks, particularly regarding heart failure. Our findings suggest a need for baseline risk assessment tools to identify variation in absolute treatment benefits and improve decision-making.
Fresh human amniotic membrane wrapping promotes peripheral nerve regeneration in PGA-collagen tubes
Authors: Iwao Atsuhiko , Saijo Hiroto , Nakayama Takafumi , Higashi Akihito , Kashiyama Kazuya , Mitsutake Norisato , Tanaka Katsumi
Published: May 2023

Background: An artificial nerve conduit can interpose the peripheral nerve defect without donor site morbidity. However, treatment outcomes are often unsatisfactory. Human amniotic membrane (HAM) wrapping has been reported to promote peripheral nerve regeneration. We evaluated the effects of a combined application of fresh HAM wrapping and a polyglycolic acid tube filled with collagen (PGA-c) in a rat sciatic nerve 8-mm defect model.Methods: The rats were divided into three groups: (1) the PGA-c group (n = 5), in which the gap was interposed with the PGA-c; (2) the PGA-c/HAM group (n = 5), in which the gap was interposed with the PGA-c bridge, then HAM (14 × 7 mm) was wrapped around it; and (3) the Sham group (n = 5). Walking-Track recovery, electromyographic recovery, and histological recovery of the regenerated nerve were evaluated at 12 weeks postoperatively.Results: Compared to the PGA-c group, the PGA-c/HAM group showed significantly better recovery in terminal latency (3.4 ± 0.31 ms vs. 6.6 ± 0.72 ms, p < 0.001), compound muscle action potential (0.19 ± 0.025 mV vs. 0.072 ± 0.027 mV, p < 0.01), myelinated axon perimeter (15 ± 1.3 μm vs. 8.7 ± 0.63 μm, p < 0.01), and g-ratio (0.69 ± 0.0089 vs. 0.78 ± 0.014, p < 0.001).Conclusion: This combined application highly promotes peripheral nerve regeneration and may be more useful than PGA-c alone.
Impairments of the arm and hand are highly correlated during subacute stroke
Authors: Reid Lydia N. , Dukelow Sean P. , Scott Stephen H.
Published: May 2023

Background: The classical description of poststroke upper limb impairment follows a proximalto-distal impairment gradient. Previous studies are equivocal on whether the hand is more impaired than the arm.Objective: To compare impairment of the arm and hand during subacute stroke.Method: A total of 73 individuals were evaluated for impairment of the upper limb within 30 days (early subacute) and within 90–150 days (late subacute) of stroke. Impairments were quantified using the Chedoke-McMaster Stroke Assessment (CMSA) for the arm and hand, Purdue Pegboard task, and a robotic Visually Guided Reaching task.Results: In the early phase 42% of participants in the early phase and 59% in the late phase received the same CMSA score for the arm and hand, with 88% and 95% of participants in the early and late phases, respectively, receiving a 1-point difference. Strong correlations exist between the CMSA arm and hand scores (early r = 0.79, late r = 0.75), and moderate – strong correlations exist between CMSA arm and hand scores and Purdue Pegboard and Visually Guided Reaching performances (r = 0.66–0.81). No systematic differences were found between the arm and hand.Conclusion: Impairments in the arm and hand during subacute stroke are highly correlated and do not support the presence of a proximal-to-distal gradient.
LAY ABSTRACTMotor impairments are a common occurrence after stroke, and are classically believed to present in a gradient from more impairment in the hand to less impairment in the arm. In this study, participants who had recently had a stroke underwent assessment with the Chedoke-McMaster Stroke Assessment, the Purdue Pegboard task, and a Visually Guided Reaching task to quantify impairment and performance of the arm and hand. Levels of impairment in the arm and hand, as measured with the Chedoke-McMaster Stroke Assessment, were found to be highly correlated. The study also showed strong correlations between quantitative measures of performance for both the arm and hand. Overall, our results do not support the presence of a proximal-to-distal gradient of impairment during subacute stroke.
Kulturen som speiles i dialogene – betydningen av en felles barnehagekultur i flerkulturelle barnehager
Authors: Giæver Katrine
Published: May 2023

Barnehagen skal legge til rette for at barn gjennom dialog og samspill støttes i å kommunisere, medvirke, lytte, forstå og skape mening (Kunnskapsdepartementet 2017, s. 23). Dette innebærer at personalet gir rom for varierte uttrykksformer og tolker barnas ytringer i kontekst, ut fra et felles kulturgrunnlag. I denne artikkelen diskuterer forfatteren hvordan felles kultur gir grunnlag for tolkning av utsagn fra barn som er i ferd med å lære et nytt språk. I lys av teoretiske perspektiver fra Hannah Arendt og Mikhail Bakhtin, analyseres utsagn fra to barnehagebarn som er nye i det norske språket. Forfatteren argumenterer for at en felles barnehagekultur kan støtte tolkning av barns utsagn og kompensere for mangel av presise ord og uttrykk på norsk. For å inkludere alle barn i dialoger i barnehagen, er det derfor viktig å utvikle et felles kulturgrunnlag som åpner for gjensidig forståelse av barns ytringer.
English abstract
The Culture Reflected in the Dialogues − the Importance of a Shared Culture in Multicultural Kindergartens
Kindergarten shall ensure that through dialogue and interaction, the children shall be helped to communicate, participate, listen, understand, and create meaning (Ministry of Education, 2017, p. 23). Staff in kindergarten must open for various expressions and interpret children’s utterances in context, leaning on a common foundation. In this article, the author discusses how common culture makes a foundation for interpreting utterances from children who are learning the Norwegian language. In the light of theoretical perspectives from Hannah Arendt and Mikhail Bakhtin, two different utterances from children in kindergarten are analyzed. The author argues that a common foundation of understanding can support the interpretation of children’s utterances and compensate for lacking precise words and expressions in Norwegian. It is crucial to include all children in dialogues in kindergarten to develop a common foundation that opens a mutual understanding of children’s utterances.
Pengembangan Media Pembelajaran Berbasis Flipbook pada Materi Sistem Ekskresi untuk Meningkatkan Literasi Sains Siswa Kelas XI SMA
Authors: Andi I Nengah , Citrawathi Desak Made , Sri Ratna Dewi Ni Putu
Published: May 2023

Penelitian ini bertujuan untuk mengetahui rancang bangun, validitas dan kepraktisan media pembelajaran berbasis flipbook pada materi sistem eksresi untuk meningkatkan literasi sains siswa kelas XI SMA. Jenis penelitian ini adalah penelitian pengembangan mengacu pada model pengembangan ADDIE. Uji validitas dilakukan oleh 1 ahli media dan 1 ahli materi. Uji kepraktisan melibatkan 3 guru biologi dan 12 siswa di SMA Negeri 1 Kintamani. Siswa dibedakan berdasarkan kemampuan yaitu 4 orang siswa berkemampuan tinggi, 4 berkemampuan sedang, dan 4 berkemampuan rendah. Analisis data dilakukan secara deskriptif kualitatif dan kuantitatif. Hasil penelitian menunjukkan rancang bangun menghasilkan produk media pembelajaran berbasis flipbook pada materi sistem eksresi untuk meningkatkan literasi sains siswa, validitas media pembelajaran sebesar 84,4% dengan kriteria sangat valid, dan kepraktisan flipbook sebesar 90,6% dengan kriteria sangat praktis. Berdasarkan hasil penelitian tersebut, flipbook yang dikembangkan sangat valid dan sangat praktis sebagai media pembelajaran pada materi sistem ekskresi untuk meningkatkan literasi sains siswa kelas XI SMA.
Comparison of Bank Soundness Levels Using the Risk-Based Bank Rating Method Before and During the Covid-19 Pandemic
Authors: Pradnyani Ni Made Wira Dwi Ratna , Artini Luh Gede Sri
Published: May 2023

The financial system plays a very important role in achieving sustainable growth rates. Banks with their financial performance are the main role in a country's financial system. This study aims to determine differences in bank soundness level using the Risk-Based Bank Rating method in the aspects of Risk Profile, Good Corporate Governance, Earnings, and Capital before and during the Covid-19 pandemic. This research is conducted at commercial banks in Indonesia with a total sample of 84 banks registered at OJK. The data analysis technique used is the Wilcoxon Signed Rank Test. The results show that the aspects of Risk Profile which are measured using LDR, Earnings which are measured using ROA and NIM, and Capital which is proxied by CAR there are significant differences during the Covid-19 pandemic. The results also show that there was no significant difference in the Risk Profile aspect as measured using the NPL and Good Corporate Governance aspects during the Covid-19 pandemic. From a bank's soundness level point of view, commercial banks are still in a safe position even though their ROA and NIM have experienced downgrades due to the ineffective performance of banks during the pandemic. Credit restructuring and the ineffectiveness of bank lending were the main reasons for the ineffectiveness of bank performance during the pandemic.
Inferred Study Habits of Students from E-Learning – Focusing on Increasing Test Scores in Pre-Enrollment Education
Authors: Sugawara Ryo , Okuhara Shun
Published: May 2023

In this study, we used the placement test scores, e-learning history, and posttest scores obtained in the pre-enrollment education at University A conducted in 2015, 2016, and 2017 to exploratorily classify seven types of students according to learning habits (types). It was revealed that more than 80% (with the exception of English in 2016) of the highest placement test scores (Japanese ≥ 90, English ≥ 74 in this study) were of learners with learning habits (types) of long-term completion (LTrf) or mid-term completion (MTrf). Although the percentage of learners with LTrf or MTrf learning habits (types) gradually decreased as placement test scores declined, there was no significant change in learning habit trends and learning habits (types) other than for LTrf or MTrf. In addition, learners with large increases in posttest scores (posttest score - placement score) after completing e-learning were classified with learning habits (types) of LTrf or MTrf. However, it is not only the learners who improved their test scores that were progressing without bias during the learning period (LTrf or MTrf). It was also found that more than 65% progressed in their learning (logged in) without being biased during the learning period. These findings suggest that there is no significant difference between learners' learning habits (types), placement test scores, and test score growth.
Hybrid Political Regime: The Fall of Foreign Direct Investment in Mexico
Authors:   Universidad Popular Autónoma del Estado de Puebla, A.C. Business School, Mexico, Botello Juan Carlos , Baltazar Carlos Botello ,   Universidad Popular Autónoma del Estado de Puebla, A.C. Business School, Mexico
Published: May 2023

Today we can identify a variety of political and economic systems in the world. A free market economic system is more likely to work if it is based on a democratic political system. According to the Democracy Index 2021, Mexico went from being an imperfect democracy to a hybrid regime, with the risk of becoming an authoritarian regime. The transition from a political system of imperfect democracy to a hybrid regime represents a great risk for domestic and foreign private investment. There is a latent political risk for investors in this type of country, which scares away foreign direct investment. This research presents an analysis of the behavior of foreign direct investment in Mexico from 2000 to 2021 by state and political party. A point biserial correlation test is performed to prove the existence of a dependencie between the attraction of foreign investment and the political party in government. Lower capital inflows in Mexico is observed since the presence of MORENA, actual political party that is in both, the federal and some state governments. Descriptive statistics show that in most of the matches there is a dependence and also a correlation, however it is prudent to study the direction of this relationship and the strength. The findings are based on an analysis of three years of government of the MORENA political party; therefore, a longer period could be considered for future research.