bluuebunny/crossref_metadata_2025 huggingface dataset:
Alternate atxA and acpA dependent response of Bacillus anthracis to serum, HCO3- and CO2
Authors: Glinert Itai , Bar-David Elad , Ben-Shmuel Amir , Sittner Assa , Puni Reut , Laredo Shira , Kobiler David , Weiss Shay , Levy Haim
Published: February 2023

Bacillus anthracis overcomes host immune responses by producing capsule and secreting toxins. Production of these virulence factors in response to entering the host environment was shown to be regulated by atxA, the major virulence regulator, known to be activated by HCO3- and CO2. While toxin production is regulated directly by atxA, capsule production is independently mediated by two regulators; acpA and acpB. In addition, it was demonstrated that acpA has at least two promotors, one of them shared with atxA. We used a genetic approach to study capsule and toxin production under different conditions. Unlike previous works utilizing NBY, CA or R-HCO3- medium under CO2 enriched conditions, we used a sDMEM-based medium. Thus, toxin and capsule production can be induced in ambient or CO2 enriched atmosphere. Using this system, we could differentiate between induction by 10% NRS, 10% CO2 or 0.75% HCO3-. In response to high CO2, capsule production is induced by acpA based response in an atxA-independent manner, with little to no toxin (protective antigen PA) production. atxA based response is activated in response to serum independently of CO2, inducing toxin and capsule production in an acpA or acpB dependent manner. HCO3- was also found to activate atxA based response, but in non-physiological concentrations. Our findings may help explain the first stages of inhalational infection, in which spores germinating in dendritic cells require protection (by encapsulation) without affecting cell migration to the draining lymph-node by toxin secretion.
Searching for Variables Related to Victim Blaming in a Disaster Situation: Negative Emotions, Similarity, and Community Resilience
Authors:   Crisis and Emergency Management: Theory and Praxis, Ham Seungkyung
Published: February 2023

This study explores potential variables influencing victim blaming. An empirical analysis is conducted with a focus on the concepts presented in the culpable control model and the defensive attribution theory, both of which explain victim blaming. This article further explores whether community resilience can reduce victim blaming. A survey was conducted on 210 adults and the results reveals a positive correlation between negative emotions and victim blaming. Victim blaming increases in cases where there was no similarity between the victim and the observer compared to where there is a similarity. It is also analyzed that the group with high community resilience has fewer victim blaming than the group with low community resilience. Finally, as the results of exploring the variables affecting negative emotions, it is confirmed that the higher the uncertainty about disaster risk, the higher the negative emotions related to disaster events. This study discusses the theoretical and practical implications based on the results.
ANÁLISE TEMPORAL E ESPACIAL DOS CASOS DE COVID-19 NAS REGIÕES GEOGRÁFICAS IMEDIATAS DO BRASIL
Authors: Alzamora Pedro Loures , Ferreira Daniel Victor , Rodrigues Isadora Cristina de Matos , Sena Julia Fonseca de , Ganem Marcelo , Locatelli Marcelo Sartori , Santos Thiago Henrique Moreira , Cunha Evandro Landulfo Teixeira Paradela , Guiginski Janaina Teodoro , Franco Ramon Adrian Salinas , Bernardes Tereza , Silva Ana Paula Couto da , Meira Junior Wagner
Published: February 2023

O geoprocessamento de dados e as análises espaciais são ferramentas importantes para o estudo de fenômenos como a disseminação de doenças pelo território e ao longo do tempo. O objetivo deste estudo é investigar, utilizando a Análise Exploratória de Dados Espaciais (AEDE), as alterações nos padrões de distribuição geográfica da Covid-19 no Brasil em dois períodos distintos da pandemia: (i) entre abril e agosto de 2020; e (ii) entre novembro de 2020 e março de 2021. Para tanto, as estatísticas I de Moran e LISA foram aplicadas aos dados referentes a três indicadores epidemiológicos: casos acumulados, novos casos e letalidade da doença. Os resultados encontrados e as visualizações propostas apresentam uma perspectiva ampla sobre a variação nos casos de Covid-19 nas regiões brasileiras e colaboram para um melhor entendimento sobre as dinâmicas epidemiológicas no Brasil no primeiro ano da pandemia de Covid-19.
Are firm size, firm complexity, and managerial ownership able to affect audit fee?: The evidence in Philippines and Indonesia as emerging countries
Authors: Syafii Bayu Hartarto , Dewi Nurul Hasanah Uswati
Published: February 2023

There are some factors that are influential in increasing the audit fee. This study aims to determine several factors affecting the increasing audit fees. Several factors that can affect the increasing audit fees for companies are firm size, firm complexity, and managerial ownership, with return on assets and leverage for controlling factors. This research is a quantitative method that uses all data collected as a sample. The main data are financial statements of Indonesian companies listed on the Indonesia stock exchange, and financial statements of Philippine companies listed on the Philippines stock exchange in 2017-2019 with the total sample of each country is 82 companies and 36 companies. Analyze were performed the classical assumption test, multiple linear regression analysis using SPSS 23 version. The results of the study show that firm size and firm complexity significantly influence audit fees. in contrast, managerial ownership has no significant effect on audit fees.
The effect of tax avoidance and tax risk on firm risk
Authors: Yuwono Andrie , Mustikasari Elia
Published: February 2023

This study aims to determine whether tax avoidance and tax risk have an influence on firm risk. This study uses data in the form of annual financial statements of manufacturing companies listed on the Indonesia Stock Exchange (IDX) from 2014 to 2018. The results of this study show that tax avoidance and tax risk have a positive effect on firm risk. The results of this study prove the signaling theory that company management sends signals in the form of information about tax avoidance and tax risk to investors. The investors then use the information as a tool in making decisions in the future.
Generalized Hyers-Ulam-Rassisa Stability of An Additive (Î²1,Î²2)-Functional Inequalities With n- Variables In Complex Banach Space
Authors: An Ly van
Published: February 2023

In this paper we study to solve the o f additive (Î²1,Î²2)-f unctional inequality with nâˆ’variables and their Hyers-Ulam stability. First are investigated in complex Banach spaces with a fixed point method and last are investigated in complex Banach spaces with a direct method. I will show that the solutions of the additive (Î²1,Î²2)-f unctional inequality are additive mapping. Then Hyersâˆ’Ulam stability o f these equation are given and proven. T hese are the main results o f this paper .
Mathematical Modelling and Numerical Simulation of Transmission Dynamics of	COVID-19 Pandemic
Authors: SOME WindjirÃ© , LAMIEN KassiÃ©nou , SO OussÃ©ni , SOME Blaise
Published: February 2023

Â In this paper we have conceived an original deterministic model for the propagation of Covid-19 dynamics. Mathematical analysis of the model has been done and reveals the existence of a single disease-free equilibrium witch is locally and asymptotically stable. The basic reproduction number Â has also been evaluated and gives an idea on the disease evolution in the world. This is because if , the disease disappears whereas if , the disease remains in the population. Numerical results are consistent with the theoretical results and highlight the effect of the infectious contact rate Î± on the evolution of the pandemic.Â
Influence of temperature distribution on the foaming quality of foamed polypropylene composites
Authors: Yang Xin , Pei Xiang-lin , Xu Jia-jie , Yang Zhi-peng , Gong Wei , Zhong Jin-cheng
Published: February 2023

The foamed polypropylene (PP) composites were prepared by injection molding process. Fourier’s law and software were used to calculate and simulate the internal temperature distribution of PP composites, respectively, and the influence of the temperature distribution on the foaming quality of foamed PP composites was further analyzed. The result showed that the calculative and simulated results of temperature distribution in different thermal transfer directions had great reproducibility. In different isothermal planes, the temperature from the nozzle to the dynamic mold gradually decreased. The isothermal plane with a temperature of 370.36 K had a better foaming quality, average diameter of cell and cell density were 28.46 µm and 3.7 × 1010 cells·cm−3, respectively. In different regions of the same isothermal plane, the temperature gradually decreased from the center to the edge. The foaming quality in the region (c) at a temperature of 335.86 K was ideal, and the average diameter of cell and the cell density were 26.5 µm and 2.39 × 1010 cells·cm−3, respectively. This work could provide prediction for improving the foaming quality of foamed polyolefin composites.
The association of paraoxonase I gene polymorphisms Q192R (rs662) and L55M (rs854560) and its activity with metabolic syndrome components in fars ethnic group
Authors: Marjani Abdoljalal , Poursharifi Nahid , Hashemi Mohammad Mostakhdem , Sajedi Atefe , Tatari Mahin
Published: February 2023

Objectives

Metabolic syndrome (MetS) may cause premature development of some diseases. PON1 genes may be involved in the pathogenesis of MetS. The aim of study was to evaluate the association between Q192R and L55M gene polymorphisms and its enzyme activity with the MetS components in subjects with and without MetS.

Methods

Polymerase Chain Reaction and Restriction Fragment Length Polymorphism analysis were performed to determine polymorphisms of the paraoxonase1 gene in subjects with and without metabolic syndrome. Biochemical parameters were measured by spectrophotometer.

Results

The MM, LM, and LL genotype frequencies of the PON1 L55M polymorphism were 10.5, 43.4, and 46.1%, and 22.4, 46.6, and 31% and; the QQ, QR, and RR genotype frequencies of the PON1 Q192R polymorphism were 55.4, 38.6 and 6%; and 56.5, 34.8 and 8.7% in subjects with and without MetS, respectively. The L and M allele frequencies were 68 and 53%; and 32 and 47% for PON1 L55M in subjects with and without MetS, respectively. The Q and R allele frequencies for PON1 Q192R were 74 and 26% in both groups. There were significant differences in HDL-cholesterol level and PON1 activity in the genotypes QQ, QR, and RR of the PON1 Q192R polymorphism in subjects with MetS.

Conclusions

The PON1 Q192R genotypes had only effected on PON1 activity and HDL-cholesterol level in subjects with MetS. Different genotypes of the PON1 Q192R seem to be important candidates to make the subjects susceptible to MetS in the Fars ethnic group.
Comparison of developmental outcomes in children with permanent and transient congenital hypothyroidism
Authors: Büyükavcı Mehmet Akif , Dundar Ismail
Published: February 2023

Objectives

Congenital hypothyroidism (CH) is still one of the most common causes of preventable cognitive impairment in children, and its early detection and treatment prevent irreversible neurodevelopmental delay. Depending on the underlying cause, cases with CH may be transient or permanent. This study aimed to compare the developmental evaluation results of transient and permanent CH patients and to reveal any differences.

Methods

A total of 118 patients with CH, who were followed up jointly in pediatric endocrinology and developmental pediatrics clinics, were included. The patients’ progress was evaluated per the International Guide for Monitoring Child Development (GMCD).

Results

Of the cases, 52 (44.1%) were female, and 66 (55.9%) were male. While 20 (16.9%) cases were diagnosed with permanent CH, 98 (83.1%) were diagnosed with transient CH. According to the results of the developmental evaluation made with GMCD, the development of 101 (85.6%) children was compatible with their age, while 17 (14.4%) children had delays in at least one developmental area. All 17 patients had a delay in expressive language. Developmental delay was detected in 13 (13.3%) of those with transient CH and 4 (20%) with permanent CH.

Conclusions

There is difficulty in expressive language in all cases of CH with developmental delay. No significant difference was found between the developmental evaluations of permanent and transient CH cases. The results revealed the importance of developmental follow-up, early diagnosis and interventions in those children. GMCD is thought to be an important guide to help monitoring the development of patients with CH.
Norm Externalisation and the Evolution of Cooperation
Authors: Valković Martina
Published: February 2023

In a recent article, Kyle Stanford gives an account of what he terms “externalisation”, understood as our tendency to objectify or externalise moral demands and obligations. According to Stanford, externalisation is a distinctive feature of our moral psychology which is adaptive since it enables and preserves cooperation. I claim that the main issue with this account is that it assumes an overly psychological and individualist, inward-to-outward looking perspective. I advocate taking an alternative perspective that turns the spotlight to social practices and the social reality they create. I show how, seen in this light, norm externalisation becomes a side-effect instead of an adaptation deserving of a special explanation.
The crystal structure of hexalithium decavanadate hexadecahydrate, H32Li6O44V10
Authors: Liu Wanxing , Wang Baolei , Yang Yanbing , Liu Dong , Dai Yifan , Zhang Meiyu
Published: February 2023

H32Li6O44V10, orthorhombic, Pnnm (no. 58), a = 10.3463(7) Å, b = 17.6637(14) Å, c = 9.2458(8) Å, V = 1689.7(2) Å3, Z = 2, Rgt
(F) = 0.0436, wR

ref
(F
2) = 0.1271, T = 293 K.
Mesh-independent multidimensional coupling of surface and subsurface water flow models
Authors: Novikov Konstantin
Published: February 2023

We present a new approach for multidimensional surface–subsurface flow coupling. The method does not require mesh-to-canal refinement or alignment and is based on numerical characteristics of the intersection of one-dimensional hydraulic object beds and the surface faces of the 3D tetrahedral mesh. The method is validated using widely recognized tilted v-catchment with subsurface and Borden catchment benchmarks.
The new sea ice thermodynamics code for the INM RAS Earth System model: The design and comparison of one- and zero-dimensional approaches with the observational data
Authors: Petrov Sergey S. , Zyuzin Vladimir K. , Iakovlev Nikolay G.
Published: February 2023

This work is devoted to the comparison of one- (1-D) and zero-dimensional (0-D) models of sea ice thermodynamics. 1-D thermodynamics solvers imply the solution of the diffusion equation with penetrating radiation in the moving domain (moving boundary problem), while 0-D implementations neglect the heat capacity of ice and penetrating radiation, that leads to a linear temperature profile by the construction. So far, some climate models use 0-D implementation of thermodynamics in a block of sea ice, while other models use 1-D implementation with a small number of nodes. In this work we present our fully implicit 0-D and 1-D version of snow–ice thermodynamics, which relieves the model of Courant-type time step constraints. Implicitness is achieved by the relaxation method for nonlinear heat capacity and thermal conductivity coefficients with simultaneous search for the temperature that satisfies the boundary conditions. We introduce the experiment with analytical forcing to compare evolution of temperature profiles. This model experiment shows that 0-D model underestimates ice thickness and overestimates the amplitude of temperature profile variation compared to 1-D solution. Despite the large differences in thickness and internal temperatures, the surface temperatures are very close. The models were also validated on the data of the SHEBA field experiment. According to comparison with observation data, the 0-D model predicts ice thickness and spatiotemporal temperature distribution much worse compared to 1-D model, but the amplitude of error in surface temperature is slightly greater for 0-D code. It can be concluded that 0-D model of sea ice thermodynamics is a good tool for predicting surface temperature, but it gives a large error in thickness and temperature distribution.
Aging Resistance of Bitumen Modifiers: A Comprehensive Review
Authors: Abraham Sarah Mariam , Verma Muskan , Kakade Vijay
Published: February 2023

The deterioration of physical and mechanical properties of bituminous materials that are attributable to the aging of bitumen is one of the major causes of reduction in service life of flexible pavements. Thermal-oxidation and photo-oxidation aging are the two major types of aging of bitumen. Heat and oxygen cause thermal-oxidative aging, whereas ultraviolet irradiation and oxygen causes ultraviolet photo-oxidative aging of bitumen. Aging of binder leads to significant changes in the chemical composition of bitumen resulting in reduction of cracking resistance of bituminous mixes because of hardening of bitumen. So, it is quintessential to reduce the rate of hardening of bitumen induced by aging for prevention of premature failure of flexible pavements. The type of bitumen used for production of bituminous mixes have a significant effect on aging resistance of bitumen. The bitumen can be modified by using different types of modifiers such as antioxidants, bio-oils, nanomaterials, polymers, rubber, and ultraviolet absorbers. In addition to this, the modifiers such as fillers, warm mix additives, and rejuvenators also affect the aging resistance of bitumen. However, the effectiveness of these modifiers in preventing the hardening of bitumen because of aging varies with type of aging. The modifiers that exhibit improvement in thermal-oxidative aging resistance of bitumen are found to be less effective in improvement in photo-oxidative aging resistance and vice-versa. So, it is imperative to understand the effectiveness of different types of bitumen modifiers for the prevention of thermal-oxidative and photo-oxidative aging of bitumen. This review documents the resistance of different types of modifiers to thermal-oxidative and photo-oxidative aging. Finally, the scope for future work based on the critical gaps identified from existing works is also provided to assist further research.
RAMAN GAIN AND STRUCTURAL OF TELLURITE-PHOSPHATE GLASSES WITH DIFFERENT MODIFIERS DOPING WITH Er2O3
Authors:   Physics Department, Faculty of Science, Menoufa University, Shebin El-Koom, Menoufa 32511, Egypt, OTHMAN H. A. , ALQAHTANI M. M. ,   Department of Physics, Faculty of Science, King Khalid University, P.O. Box 9004, Post. Code: 61421, Abha, Saudi Arabia., REBEN M. ,   Faculty of Materials Science and Ceramics, AGH – University of Science and Technology, al. Mickiewicza 30, 30-059 Cracow, Poland., YOUSEF EL S. ,   Department of Physics, Faculty of Science, King Khalid University, P.O. Box 9004, Post. Code: 61421, Abha, Saudi Arabia.,   Faculty of Science, Physics Department, Al Azhar University, Assiut branch, Assiut, Egypt.
Published: February 2023

A glass series of Te-glasses (70TeO2- 10P2O5- 10ZnO- 5PbF2) modified with 5mol % of different modifiers (WO3, Al2O3, CdO, SrO, BaO), that was then doped with 600ppm Er2O3 was prepared by melt quench technique. The effect of modifier oxide on the Teglass structure was studied using Raman spectroscopy. The Obtained Raman spectra reveal the characteristic structural units TeO4 and TeO3. Er2O3 doping along with the type of oxide modifier influenced the tellurite glass network and hence the Raman spectral features. The change in the Boson peak features depend on the rare earth ion doping. The obtained Raman spectra were deconvoluted to follow the structural changes. The deconvoluted data show a transformation of TeO4 to TeO3 upon the addition of metal oxides. Due to the higher coordination of WO3 and Al2O3 that offers more oxygens when compared with alkaline modifiers, the TeO3 structural group is dominated. Raman gain was calculated for the prepared glasses. Al2O3 modified glass sample has the highest Raman gain.
FABRICATION AND CHARACTERIZATION OF Mn-CdS NANOPLATES AND THEIR PHOTOCATALYTIC PERFORMANCES
Authors:   College of Mechanical Engineering, Hunan University of Arts and Science, Changde 415000, People’s Republic of China, XU L. , NING X.T. ,   Hunan University of Humanities, Science and Technology, School of Environmental and Materials Engineering
Published: February 2023

Graphene/Mn-doped CdS nanoplates (G/Mn-CdS NP) composite photocatalysts were prepared via a microwave-assisted method and characterized via XRD, UV-Vis spectroscopy, XPS, SEM, TEM, and HRTEM. The as-prepared G/Mn-CdS NP composite displayed a maximum photodegradation of methylene orange dye of 79.7% under visible light irradiation. The unique nanoplate structure, graphene support, and Mn2+ doping in the nanocomposite induced synergistic effects in its photocatalytic performance, which enhanced its charge transfer, improved its light utilization, and suppressed the recombination of photogenerated electron-hole pairs. Such composite photocatalysts are expected to have great practical applications for environmental remediation.
EFFECT OF Se ADDITIVE ON THE STRUCTURE, PRE-CRYSTALLIZATION CRITERIA AND CRYSTALLIZATION KINETIC PARAMETERS IN GLASSY MELT-QUENCHED As-S ALLOY
Authors:   Physics Department, Faculty of Science, Al-Azhar University, Nasr City 11884, Cairo, Egypt, QASEM A. , SHAABAN E. R. ,   Physics Department, Faculty of Science, A1-Azhar University, Assiut 71542, Egypt, HASSAAN M. Y. ,   Physics Department, Faculty of Science, Al-Azhar University, Nasr City 11884, Cairo, Egypt, RAFIQUE S. ,   Multidisciplinary Nanotechnology Centre, College of Engineering, Swansea University, Swansea SA1 8EN, United Kingdom, MOUSTAFA M. G. ,   Physics Department, Faculty of Science, Al-Azhar University, Nasr City 11884, Cairo, Egypt,   Physics Department, College of Science & Arts, Jouf University, Qurayat, P. O. 756, Saudi Arabia, YOUSEF EL S. ,   Physics Department, Faculty of Science, King Khalid University, P.O. Box 9004, Abha, Saudi P.O. Box 9004, Saudi Arabia Arabia,   Research Center for Advanced Materials Science (RCAMS), King Khalid University, Abha 61413
Published: February 2023

The present framework is consecrated to studying structural parameters, pre-crystallization criteria and crystallization kinetics by non-isothermal and iso-conversional methods for melt-quenched As40S60-xSex glassy alloys, with (x=0, 15, 30, 45 and 60 at. %). Energy dispersive x-ray analysis of the As40S60-xSex glassy system appears that the constituent element ratio of the studied samples have been agreed with the nominal compositions. Likewise, Differential Scanning Calorimetry (DSC) and x-ray diffraction (XRD) has been utilized to depict the thermal and structural properties, respectively. Four characteristic temperatures linked to several phenomena are obviously noticed in the studied DSC traces. The first one is Tg that harmonizes with the glass transition temperature. The second one is Tc that harmonizes with the onset of the crystallization temperature. The third one, T p corresponds to the peak crystallization temperature. The last characteristic temperature, T p is the melting point. The XRD analysis signalizes to the amorphous structure of the as-prepared glassy alloys. The crystallization kinetics of the powdered of As40S60-xSex, have been investigated under non-isothermal and iso-conversional conditions. Besides, the values of diverse kinetic parameters such as the activation energy of glass transition, the weight stability criterion, and Avrami exponent, have been computed. The activation energies of the crystallization process of the As40S60-xSex glassy alloys were determined by means of classical and also by the iso-conversional methods. The results referred that the rate of crystallization is linked to the thermal stability and glass-forming ability. The kinetic parameters that computed via some classical and isoconversional methods, were found to be dependent on the change of Se content.
ELECTRIC FIELD INDUCED RESISTANCE SWITCHING AND MAGNETIC SWITCHING PROPERTIES OF Fe70Ga30 NANO THIN FILM
Authors:   School of Electrical and Electronic Engineering, Tianjin Key Laboratory of Film Electronic & Communication Devices, Tianjin University of Technology, Tianjin 300384, China, LI H. , HAN Y. M. ,   School of Electrical and Electronic Engineering, Tianjin Key Laboratory of Film Electronic & Communication Devices, Tianjin University of Technology, Tianjin 300384, China, REN X. M. ,   School of Electrical and Electronic Engineering, Tianjin Key Laboratory of Film Electronic & Communication Devices, Tianjin University of Technology, Tianjin 300384, China, TAO Z. ,   School of Electrical and Electronic Engineering, Tianjin Key Laboratory of Film Electronic & Communication Devices, Tianjin University of Technology, Tianjin 300384, China, ZHANG K. L. ,   School of Electrical and Electronic Engineering, Tianjin Key Laboratory of Film Electronic & Communication Devices, Tianjin University of Technology, Tianjin 300384, China
Published: February 2023

Fe70Ga30 magnetic nano thin films of different thicknesses were successfully fabricated by ion beam deposition coating on Si/SiO2 substrates. The crystal structure of Fe70Ga30 magnetic nano thin films were characterized by Grazing incidence X-ray diffraction (GIXRD). Surface morphology is studied using Atomic Force Microscopy (AFM). The magnetic properties of nano thin films have been measured by Vibrating Sample Magnetometer (VSM). The result reveals that the nano thin films have good soft magnetic properties. We measured the current–voltage (I–V) curves of Fe70Ga30 nano thin films, the behavior of resistance switching by more than an order of magnitude was obtained .The measurement performed on Fe70Ga30 nano thin films reveal that the resistant switching behavior is reversible and the transformation occurs between high (low) resistance states. The manipulation could be attributed to the Coulomb blockade effect. The existence of anomalous Hall effect was found during the Hall effect test on the nano thin films surface. The surface carrier density of Fe70Ga30 nano thin films changed when Hall effect test was performed resulting in magnetic switching.
DESIGN OF SINGLE MOLECULE AROMATIC MOLECULAR SWITCHES WITH METAL ELECTRODES-A COMPUTATIONAL APPROACH
Authors:   Department of Electrical and Electronics Engineering, BITS Pilani, Dubai Campus, Dubai 345055, UAE, KOYADEEN T. R. , KUMAR A. ,   Department of Electrical and Electronics Engineering, BITS Pilani, Dubai Campus, Dubai 345055, UAE
Published: February 2023

Designed 1,4-benzene dithiol, 1,4-benzene diamine, and 1,4-benzene dicarboxylic acid based molecular switches with gold, silver, platinum and palladium metal electrodes by the first-principles approach. The electronic properties of the designed metal-moleculemetal sandwich structure are investigated with density functional theory (DFT) method. A series of benzene derivatives to explore the physical behaviour of conductance interpret in terms of nature of molecular backbone, anchoring group, contact geometry, nature of electrode material, molecular length, connectivity site, density of states, HOMO-LUMO gap, ionization potential and potential energy were systematically studied and compared. The findings of the present work clearly reveal that for the design of an efficient molecular switch, palladium and thiol are the best among electrode and anchoring group respectively. Palladium electrode shows high switching band gap ratio for ON and OFF state compared to Au, Ag, and Pt. The first principles approach can be used to screen and minimize the need for experimental approach which could be expensive
EFFECT OF SiO2 COATING ON MICROSTRUCTURE AND DIELECTRIC PROPERTIES OF BaZr0.1Fe0.02Ti0.88O3 CERAMICS
Authors:   Chemical College, Shijiazhuang University, Shijiazhuang 050035, China, LI Z. , LI Y. ,   Analysis and Testing Research Centre, North China University of Science and Technology, Tangshan 063210, China, ZHOU H. ,   Chemical College, Shijiazhuang University, Shijiazhuang 050035, China, WANG Z. ,   Chemical College, Shijiazhuang University, Shijiazhuang 050035, China
Published: February 2023

BaCO3, ZrO2, TiO2 and Fe2O3, were used as the starting materials, the BaZr0.1Fe0.02Ti0.88O3 powders are prepared using solid state synthesis method, the powders were coated with SiO2, the influence of different SiO2 package on the structure, micro morphology and dielectric properties of the samples is studied. The results show that all the samples have typical diffraction peaks of perovskite crystal; however, with the increase of the amount of inclusion of SiO2, a part of SiO2 enters into the crystal lattice, forming the BaTiSi4O11 phase in the body. The grain size of the sample coated with SiO2 is significantly larger than that of the sample not coated, with the continuous increase of the amount of coating, the grain size has no obvious change, and the size distribution is relatively uneven. With the increase of SiO2 content, the dielectric constant of the sample increases first and then decreases, and the dielectric loss of the sample decreases first and then increases. Due to the coating of SiO2, the dielectric constant is 2736, and the dielectric loss is 0.033 when the content of SiO2 is 1 wt%.
SYNTHESIS AND MICROSTRUCTURE CHARACTERIZATION OF SOL-GEL DERIVED PHASE FRACTIONS IN PZT NANOPOWDERS
Authors:   Physics Department, Faculty of Science, Minia University, Minia 61519, Egypt, EID E. A. , EBIED M. R. ,   Physics Department, Faculty of Science, Minia University, Minia 61519, Egypt, KAID M. A. ,   Physics Department, Faculty of Science, Minia University, Minia 61519, Egypt, ALI M. G. S. ,   Physics Department, Faculty of Science, Minia University, Minia 61519, Egypt
Published: February 2023

Lead zirconate titanate (PZT) nanopowders with the composition of Pb(Zr0.52Ti0.48)O3were synthesized by a sol–gel process. The prepared PZT powders were calcinated at 500 °C,600 °C,700 °C and 750 °C for 1 h.Thermal, vibrational and Structural characteristic of PZT powder have been studied ,using thermogravimetric analysis (TGA ), fourier transform infrared (FTIR) spectroscope,and powder x-ray diffraction (XRD).Results showed that single phase perovskite pzt powders were obtained at temperature of 750 °C.By using materials analysis using diffraction (Maud) program the anisotropic microstructural characteristics (crystallite size and microstrain)and lattice parameters at different calcination temperature were determined, using anisotropic no rules approach. Also, from the same program weight fractions of tetragonal and rhombohedral phases in pzt powders at different calcination temperaturewere calculated.
ENHANCEMENTS OF GROWTH AND METABOLITES OF INDICA RICE CALLUS (ORYZA SATIVA L. CV. PATHUMTHANI1) USING TiO2 NANOPARTICLES (NANO-TiO2)
Authors:   College of Nanotechnology, King Mongkut’s Institute of Technology Ladkrabang, Bangkok, 10529, Thailand, CHUTIPAIJIT S. , SUTJARITVORAKUL T. ,   Faculty of Science and Technology, Pathumwan Institute of Technology, Bangkok, 10330, Thailand
Published: February 2023

In this research, the effects of a various in concentration of TiO2 nanoparticles (NanoTiO2) were applied to study the cell growth, metabolites and antioxidant responses of callus in indica rice plants. Dose-dependent changes in growth performances, metabolite accumulations and antioxidant activities of callus were found. Mature seeds of indica rice cv. Pathumthani1 were cultured in callus induction medium with different concentrations of Nano-TiO2 (0-600 mg L-1 ). After five weeks of cultivation, the callus formations were measured in fresh weights and dry weights, and the contents of phenolic compounds, flavonoids, and the antioxidant activities of callus extracts were assayed. The Nano-TiO2 induced of fresh weights and dry weights in callus formations when compared with the control treatment (0 mg L-1 Nano-TiO2) were also observed. The flavonoid and phenolic compound contents in rice callus exposed to 400 mg L-1 Nano-TiO2 were 118% and 139%, respectively, higher than rice callus unexposed to Nano-TiO2. Moreover, the antioxidant activities of the callus metabolites studied shows that the percentages of inhibition were up-regulated (84%) when exposed to 400 mg L-1 Nano-TiO2, as a response to the highlevel depletion of the free radicals in metabolites of rice callus. The results obtained from this research showed that the addition of Nano-TiO2 had impacts on the callus growth and metabolite accumulations in rice callus. The results suggested that addition of Nano-TiO2 at appropriate levels could role as an elicitor for biosynthesis of valuable metabolites and antioxidant properties for pharmaceutical applications in further research.
CHARACTERISTICS AND OPTICAL PROPERTIES OF NITROGEN IONS IMPLANTED TiO2 THIN FILM PREPARED BY REACTIVE DC SPUTTERING TECHNIQUE
Authors:   College of education for pure science, Mosul University, Mosul, Iraq, RABIH L. , RASOOL R. A. ,   College of education for pure science, Mosul University, Mosul, Iraq, HUSSEIN A. K. ,   College of education for pure science, Mosul University, Mosul, Iraq
Published: February 2023

This study reports on the properties of Titanium Dioxide (TiO2) thin films fabricated by Reactive DC sputtering technique on glass substrate. TiO2 thin films were implanted with several doses of N+ ions namely; (2×1015, 1×1016 and 1×1017 ions/cm2 ) using homemade implantation equipment. The optical properties of N+ ions implanted TiO2 thin films examined by UV-Vis spectrophotometry. The transparency of the N+ ion implanted TiO2 decreased with increasing of N+ ion dosage while the absorption spectrum was shifted toward visible region. The band-gap energy of N+ ion implanted TiO2 exhibited a decrease with various doses from 3.15 eV to 2.52 eV. The intensity of diffraction peak A(101) and R(110) decreased specially at the dose (1×1017 ions/cm2 ). XRD and SEM analyses indicated a degeneration of the crystal quality.
METTL14 modulates glycolysis to inhibit colorectal tumorigenesis in p53‐wild‐type cells
Authors: Hou Yichao , Zhang Xintian , Yao Han , Hou Lidan , Zhang Qingwei , Tao Enwei , Zhu Xiaoqiang , Jiang Shanshan , Ren Yimeng , Hong Xialu , Lu Shiyuan , Leng Xiaoxu , Xie Yile , Gao Yaqi , Liang Yu , Zhong Ting , Long Bohan , Fang Jing‐Yuan , Meng Xiangjun
Published: February 2023

The frequency of p53 mutations in colorectal cancer (CRC) is approximately 40–50%. A variety of therapies are being developed to target tumors expressing mutant p53. However, potential therapeutic targets for CRC expressing wild‐type p53 are rare. In this study, we show that METTL14 is transcriptionally activated by wild‐type p53 and suppresses tumor growth only in p53‐wild‐type (p53‐WT) CRC cells. METTL14 deletion promotes both AOM/DSS and AOM‐induced CRC growth in mouse models with the intestinal epithelial cell‐specific knockout of METTL14. Additionally, METTL14 restrains aerobic glycolysis in p53‐WT CRC, by repressing SLC2A3 and PGAM1 expression via selectively promoting m6A‐YTHDF2‐dependent pri‐miR‐6769b/pri‐miR‐499a processing. Biosynthetic mature miR‐6769b‐3p and miR‐499a‐3p decrease SLC2A3 and PGAM1 levels, respectively, and suppress malignant phenotypes. Clinically, METTL14 only acts as a beneficial prognosis factor for the overall survival of p53‐WT CRC patients. These results uncover a new mechanism for METTL14 inactivation in tumors and, most importantly, reveal that the activation of METTL14 is a critical mechanism for p53‐dependent cancer growth inhibition, which could be targeted for therapy in p53‐WT CRC.
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Authors: Bergman Joel
Published: February 2023

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The efficacy and toxicity of dexrazoxane use in children with cancer: A pupulation-based study from Maritimes, Canada
Authors: Cruickshank Brianne
Published: February 2023

Anthracycline induced cardiotoxicity is a well-recognized complication in pediatric oncology. The use of the cardio-protective drug dexrazoxane has gained traction despite its unclear efficacy and toxicity. A retrospective, population-based study was completed using chart and database information on children treated with anthracycline at the IWK Health Centre from 2009-2015 (n=178). The efficacy of dexrazoxane was defined as a lack of undesirable deviations in identified cardiac parameters on echocardiogram. Toxicity of dexrazoxane was defined as chemotherapy delays from any of decreased absolute neutrophil count (ANC), decreased platelets, increase in viral/bacterial episodes and febrile neutropenia (FN) episodes. Patients were stratified into groups based on the total amount of anthracycline received and whether they received dexrazoxane. Regardless of anthracycline dose, we found no significant relationships regarding cardiac function in the untreated and dexrazoxane treated groups. However, we found that patients who were treated with >250mg/m2 of anthracycline and received dexrazoxane experienced significantly more platelet delays but no cardiac benefit (p=0.007). When classified by diagnosis, we also found that dexrazoxane treated patients diagnosed with low-risk acute lymphocytic leukemia (LR-ALL) were likely to experience a delay in treatment due to both low ANC (p=0.0001) and the development of FN (p=0.02) whereas high-risk acute lymphocytic leukemia (HR-ALL) patients were likely to experience treatment delays due to thrombocytopenia (p=0.03), low ANC (p=0.0001) and FN (p=0.0001). Despite finding no significant differences regarding the efficacy of dexrazoxane as a cardio-protectant, we have shown that its use induces non-cardiac toxicities in children with cancer that contribute to treatment delays.
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Authors: Sultan Mohammad
Published: February 2023

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A case of transient constrictive pericarditis in rural Nova Scotia
Authors: Stubeda Herman
Published: February 2023

This case report describes a 32-year-old female who presented with severe dyspnea and exertional intolerance to an emergency department in a rural area of Nova Scotia. The diagnosis was made by corroborating the value of the erythrocyte sedimentation rate, the level of N-terminal prohormone of brain natriuretic peptide, and a transthoracic echocardiogram, which respectively showed an inflammatory pattern, myocardial strain, and classic sonographic findings consistent with constrictive pericarditis. The patient was treated with oral colchicine, naproxen, and prednisone resulting in complete resolution of laboratory and sonographic abnormalities. Availability of echocardiography in a rural setting can promptly and definitively diagnose and rule out many structural and functional disorders of the heart, including rare pathologies such as constrictive pericarditis.
Pre-Testing Muhammadiyah COVID-19 Guidelines in Jakarta Province
Authors: Handayani Sarah , Khoiriyah Rizqiyani
Published: February 2023

Muhammadiyah, being one of the religious-based organizations, has its affiliated members comprising 14,9% of the general Indonesian population. The Muhammadiyah Central Board declared an ad-hoc group called the Muhammadiyah COVID-19 Command Centre (MCCC) to combat COVID-19. Among the used media were the third COVID-19 guidelines publications by the MCCC. This study aimed to determine the Muhammadiyah members’ understanding of the COVID-19 Revision III Guidelines based on their consistency, clarity, relevance, credibility, and interest. This research was a descriptive qualitative type of study. The eleven informants who participated in this study, determined by purposive sampling, were Muhammadiyah members who lived and worked in the Jakarta. These Informants consisted of various professions, including health workers, teachers, district board members, nurses, drivers, traders, housewives, and students. Data collection was by online focus group discussions through the zoom cloud meetings platform. Informants discussed the five aspects of the guideline which included consistency, clarity, relevancy, credibility and interest. The contents of the guideline were found to be consistent with other similar guidelines published by the Ministry of Health (MOH). In addition, being affiliated members of the Muhammadiyah group, informants felt more comfortable trusting the Muhammadiyah-published COVID-19 guidelines. From the clarity and relevance aspect, the informants had positive perspectives on the guidelines. The design of the published guidelines attracted their interest in reading, implementing, and sharing the guidelines with others. However, the guideline did not contain the names of its drafting team nor the introduction by the Central Board leadership. It would have been a very important strategy in strengthening the credibility of the media published by the MCCC. The MCCC needed more enticing plans and methods in the dissemination of its online or printed media to the population. For online media, the published number of pages should be fixed to a less readable number.
Community Awareness for Screening Non-Communicable Diseases
Authors: Prihanti Gita Sekar , Wilyani Dwi , Isnaini Faradila , Ailani Achmad Fauzan , Humaira Azkia Akbari , Kurniawan Iga Karisma , Rahayu Kartika Puji , Hadiyanti Lisa Aprilia , Santoso Shabrina Rahma
Published: February 2023

Non-Communicable Diseases (NCD), also known as chronic diseases such as hypertension, diabetes, and obesity, are from combined genetic, physiological, environmental, and behavioral factors. The number of NCD screening visits at Ngletih Public Health Center (PHC) Kediri decreased in 2018 was 29% and became 24% in 2019, with a target of 10,718 people. This study aimed to know the factors affecting community awareness for screening NCD. The respondents are people aged 15-59 years who live in the working area of Ngletih PHC and have never been diagnosed with hypertension, diabetes, and obesity. This research used an analytical observational study with a cross-sectional design. The number of samples taken is 1,000 with purposive sampling; then, respondents filled out 27 questionnaires self-administered. The data analysis was implemented univariate, bivariate using chi-square, and multivariate using multiple logistic regression. The chi-square test showed eight variables that increase awareness for screening NCD: age, gender, education level, marital status, family history, source of health information, knowledge, and attitude. The multiple logistic regression tests showed five factors that increase awareness for screening NCD: age, gender, marital status, sources of health information, and knowledge. The dominant factor affecting community awareness for screening NCD is a source of health information (p=0.023; OR=4.353; CI=1.220-15.537).
Working Period and CO Exposure Relationship with Changes Levels COHb of Bus Station Officer
Authors: Rachmawati Siti , Suryadi Iwan , Safitri Ferlin Ayu , Firmansyah Fathoni
Published: February 2023

Carbon monoxide inhaled into the lungs will enter the blood circulation and inhibit the entry of oxygen needed by the body. This gas combines with hemoglobin to form carboxyhemoglobin (COHb). The increase in COHb in the blood will inhibit the function of oxygen transportation and will affect the health of workers. This study aims to determine the risk factors for increasing COHb in Tirtonadi Bus Station Surakarta officers. The research method used analytic observational with a cross-sectional design. The research population was 110 respondents with a purposive sampling technique to get a research sample of 43 respondents. CO levels in the environment were measured by a CO meter, while COHb levels were measured by a spectrophotometer. The research data were analyzed using Spearman rank. Statistical correlation test showed a significant relationship between CO levels in the environment and COHb levels, p-value = 0.000 and r-value = 0.897, and no significant relationship between length of work and COHb levels with p-value = 0.285 and r-value = - 0.167. CO in the environment is related to the COHb level of traffic security officers at Tirtonadi Bus Station Surakarta, and the length of work is not related to the COHb level of traffic security officers at Tirtonadi Bus Station Surakarta.
To Love Yourself: Psychological Approach to Predict Healthy Lifestyle Behaviour in Adolescents
Authors: K. Hedo Dian Jayantari Putri , Katmini Katmini
Published: February 2023

Adolescents were susceptible to problems and negativity during the pandemic times. There was an increase in adolescents’ consumption of unhealthy foods by 36%, an increase in body weight by 48%, and a decrease in physical activity and exercise by 43% globally. To function optimally in this situation, adolescents needed to do healthy lifestyle behaviour. Adolescents tended to do this when they could love themselves, which was carried out by applying self-compassion and participating in activities that benefit health. This study was conducted in 2021 and aimed to determine the relationship between self-compassion and adolescent participation in healthy lifestyle behaviour. This study used a cross-sectional design. The population was adolescents in Kediri, aged 15-19. The sample was obtained by cluster sampling, totaling 111 respondents. Independent variables were self-compassion and adolescent participation. The dependent variable was healthy lifestyle behaviour. Data were collected by questionnaires and analyzed by regression. Results showed that variables related to healthy lifestyle behaviour were self-compassion and adolescent participation (p0.001). There was a significant relationship between self-compassion (p=0.02) and participation (p0.001) with healthy lifestyle behaviour. Self-compassion and participation were predictors of healthy lifestyle behaviour, simultaneously and individually. Based on the results, adolescents needed to increase their understanding and practice of self-love in performing healthy lifestyle behaviour.
Effect of Population Density and Altitude on COVID-19 : A Spatial Pattern
Authors: Cahyati Widya Hary , Purwoko Sidiq , Farida Eko , Khairunnisa Marizka , Asturiningtyas Ika Puspita , Ashar Hadi , Puspitasari Candra
Published: February 2023

The Covid-19 pandemic that has been going on since March 2020 has spread rapidly, with high mortality In Indonesia. Central Java, Covid-19 remains a disease with a Case Fatality Rate (CFR) of 4.4% and is above Indonesia’s CFR of 3.0%. In Magelang itself,  positive cases of Covid-19 in 2020 reached 4418 and were among the top 3 cases in Central Java Province. This study’s purpose was to spatially describe the distribution of new cases of Covid-19 in terms of population density and elevation of the sub-district area in Magelang. The type of research is descriptive quantitative with ecological studies using a spatial approach. The results showed that the distribution of new cases of Covid-19 has a unique pattern in mapping based on population density and altitude. Some of the new distribution cases showed a distribution pattern following the regional elevation and almost entirely following the pattern of population density. The increase of Covid-19 tends to be higher in areas with high-density populations and low-altitude regions. This study concludes that the distribution pattern of new Covid-19 cases is influenced by population density and the area’s height during the peak period of new Covid-19 cases in 2020 at Magelang.