bluuebunny/crossref_metadata_2025 huggingface dataset:
Description and Characterization of Different Types of Lymphoma in Cats in Hong Kong
Authors: Almendros Angel , Chan Long-Ki , dos Santos Horta Rodrigo , Nekouei Omid , Hill Fraser , Giuliano Antonio
Published: May 2024

This study aimed to characterize and describe the different lymphoma types and anatomical forms in cats in Hong Kong. The clinical and histopathological data of cats diagnosed with lymphoma by cytology and/or histopathology were collected from a large diagnostic laboratory in Hong Kong. In total, 444 cats were diagnosed with lymphoma over four years (2019–2022). Like other countries where there is a low prevalence of FeLV infection, the predominant form of lymphoma was gastrointestinal (abdominal). Nasopharyngeal and peripheral nodal lymphoma were the second and third most common forms of lymphoma. The large cell/high-grade lymphoma type was much more common than the low-grade/small cell lymphoma in the study population. Domestic short hair was the most commonly affected breed in our study (n = 259/444). Among the cats with identified T/B-cell status, B-cell lymphoma (n = 61/81) prevailed as the most common phenotype. This study describes and characterizes the different types of feline lymphoma in cats in Hong Kong, adding valuable information to the body of knowledge.
Freeport as a Hub in the Art Market: Shanghai Art Freeport
Authors: Zhang Fanyu
Published: May 2024

With the soaring interest in art as an alternative investment approach and an asset class, there has been a remarkable rise in the volume of artwork transactions globally. However, trading in the art market differs from the traditional financial market; the cost of taxes, logistics, storage, and other transaction services is enormous for collectors, stimulating the emergence of related businesses, such as warehousing, bonded exhibitions, and art financial services. As an exceptional area serving the offshore economy, art freeports have become an essential venue for art trading and a ‘one-stop-shop’ centre that converges all art market participants. This article critically analyses the current literature and conducts empirical research on Shanghai FTZ International Culture Investment and Development Co., Ltd. (FTZART). It can be concluded that the current research on art freeports is limited and excludes FTZART from those that specialise in storing artworks, overlooking its potential influence in the Asian market. The art freeport has distinctive features that differ from traditional freeport models, and the context, business model, and operations of FTZART match these characteristics. Therefore, as a hub in the art market, the global art freeport agenda should not overlook FTZART, and it is essential to complement this gap in knowledge.
Emission Pattern of Biogenic Volatile Organic Compounds from Wetland Vegetation
Authors: Chen Wenbin , Wang Luxi , Wu Ju , Lun Xiaoxiu , Wang Xiaoyue , Li Xiaoyi
Published: May 2024

Biogenic volatile organic compounds (BVOCs) significantly contribute to atmospheric chemistry at both regional and global scales. The composition and intensity of BVOC emissions vary significantly among different plant species. Previous studies have focused on BVOC emissions from tree species, but the results of research on BVOC emissions from wetland plants are still limited. Therefore, in this study, BVOCs emitted by three aquatic plants (Phragmites australis, Typha angustifolia, and Iris pseudacorus) were sampled and analyzed using a dynamic headspace technique combined with GC-MS at daily scales. The diurnal observation data showed that the total BVOC emission rates of the three plants peaked with the increase in environmental factors (temperature, PAR, and water temperature). P. australis was the only of the three plants that emitted isoprene with a high rate of 48.34 μg·g−1Dw·h−1. Moreover, the peak emission rates of total BVOC (78.45 μg·g−1Dw·h−1) in P. australis were higher than most tree species. The emissions rates of volatile organic compounds, including monoterpenes, oxygenated volatile organic compounds, alkanes, and other volatile organic compounds, were statistically correlated across all species. The emission rates of isoprene from P. australis had significant associations with intercellular CO2 concentration (Ci) (0.58, p < 0.05) and transpiration rate (Tr) (−0.63, p < 0.01). The emission rates of monoterpenes from P. australis were found to have a significantly positive correlation with the net photosynthetic rate (Pn) (0.58, p < 0.05) while T. angustifolia (−0.59, p < 0.05) and I. pseudacorus (−0.47, p < 0.05) showed the opposite trend. Such findings hold significance for the refinement of localized emission inventories and the development of comprehensive emission process models in future research, as BVOC emissions from wetland plants were reported here for the first time.
Complexity and Nonlinear Dependence of Ionospheric Electron Content and Doppler Frequency Shifts in Propagating HF Radio Signals within Equatorial Regions
Authors: Akerele Aderonke , Rabiu Babatunde , Ogunjo Samuel , Okoh Daniel , Kascheyev Anton , Nava Bruno , Bolaji Olawale , Fuwape Ibiyinka , Oyeyemi Elijah , Olugbon Busola , Akinpelu Jacob , Ajani Olumide
Published: May 2024

The abundance of ions within the ionosphere makes it an important region for both long range and satellite communication systems. However, characterizing the complexity in the ionosphere within the equatorial region of Abuja, with geographic coordinates of 8.99° N and 7.39° E and a geomagnetic latitude of −1.60, and Lagos, with geographic coordinates of 3.27° E and 6.48° N and a dip latitude of −1.72°, is a challenging and daunting task due to the intrinsic and external forces involved. In this study, chaos theory was applied on data from both an HF Doppler sounding system and the Global Navigation Satellite System (GNSS) for the characterization of the ionosphere over these two tropical locations during 2020–2021 with respect to the quality of high-frequency radio signals between the two locations. Our results suggest that the ionosphere at the two locations is chaotic, with its largest Lyapunov exponent values being greater than 0 (0.011≤λ≤0.041) and its correlation dimension being in the range of 1.388≤D2≤1.775. Furthermore, it was revealed that there exists a negative correlation between the state of the ionosphere and signal quality at the two locations. Using transfer entropy, it was confirmed that the ionosphere interfered more with signals during 2020, a year of lower solar activity (sunspot number, 8.8) compared to 2021 (sunspot number, 29.6). On a monthly scale, the influence of the ionosphere on signal quality was found to be complicated. The results obtained in this study will be useful in communication systems design, modelling, and prediction.
Simulation and Diagnosis of Physical Precipitation Process of Local Severe Convective Rainstorm in Ningbo
Authors: Lu Tingting , Ding Yeyi , Liu Zan , Wu Fan , Xue Guoqiang , Zhang Chengming , Fu Yuan
Published: May 2024

On 31 July 2021, Ningbo, an eastern coast city in China, experienced a severe convective rainstorm, characterized by intense short-duration precipitation extremes with a maximum rainfall rate of 130 mm h−1. In this research, we first analyzed this rainstorm using Doppler radar and precipitation observation and then conducted high-resolution simulation for it. A three-dimensional precipitation diagnostic equation is introduced to quantitatively analyze the microphysical processes during the rainstorm. It is shown that this rainstorm was triggered and developed locally in central Ningbo under favorable large-scale quasi-geostrophic conditions and local conditions. In the early stage, the precipitation increase is mainly driven by the strong convergence of water vapor, and a noticeable increase in both the intensity and spatial extent of uplift promotes the upward transportation of water vapor. As the water vapor flux and associated convergence weaken in the later stage, the precipitation reduces accordingly. Cloud microphysical processes are also important in the entire precipitation process. The early stage updraft supports the escalations in raindrops, with the notable fluctuations in raindrop concentrations directly linked to variations in ground precipitation intensity. The behavior of graupel particles is intricately connected to their melting as they fall below the zero-degree layer. Although cloud water and snow exhibit changes during this period, the magnitudes of these adjustments are considerably less pronounced than those in raindrops and graupels, highlighting the differentiated response of various condensates to the convective dynamics. These results can help deepen the understanding of local severe rainstorms and provide valuable scientific references for practical forecasting.
Assessing the Accuracy of 50 Temperature-Based Models for Estimating Potential Evapotranspiration (PET) in a Mediterranean Mountainous Forest Environment
Authors: Proutsos Nikolaos D. , Fotelli Mariangela N. , Stefanidis Stefanos P. , Tigkas Dimitris
Published: May 2024

Potential evapotranspiration (PET) is a crucial parameter for forest development, having an important role in ecological, biometeorological, and hydrological assessments. Accurate estimations of PET using the FAO–56 Penman–Monteith (FAO–56 PM) benchmark method require a wide range of data parameters, which are not typically available at meteorological stations installed in forest environments. The aim of this study is to investigate the accuracy of various methods with low data requirements for assessing PET in a Mediterranean forest environment and propose appropriate alternatives for accurate PET estimation. Specifically, 50 temperature-based methods were evaluated against the FAO–56 PM method in a sub-humid forest in northern Greece, using high-quality daily meteorological data. The outcomes indicate that temperature-based methods offer a viable alternative for PET estimation when data availability is limited, with a considerable number of methods (22) presenting low deviations (up to 10%) compared to the benchmark method. Temperature-based models outperformed those incorporating water-related parameters (as relative humidity or precipitation) in Mediterranean forest environments. The top performing methods in the study site, based on several statistical indices, were the equations of Ravazzani et al., proposed in 2012, followed by Hargreaves–Samani in 1985 and Heydari and Heydari in 2014.
Ocean Surface Warming and Long-Term Variability in Rainfall in Equatorial Pacific Atolls
Authors: White Ian , Falkland Tony , Redfern Farran
Published: May 2024

Freshwater availability in Pacific equatorial atolls is highly variable because of the influence of El Niño–Southern Oscillation (ENSO) on rainfall. IPCC projections for the central and western tropical Pacific suggest annual rainfall (Pa) will increase as sea surface temperature (SST) rises. Future changes in ENSO frequency and intensity and in hydrological droughts, however, are uncertain. Here, trends in monthly, seasonal, annual, annual maximum, and minimum rainfall in two equatorial atolls in the eastern and central tropical Pacific are compared with trends in the SST of the surrounding Nino regions from 1951 to 2023. Significant increasing trends in the warm season, annual, and annual maximum SST in the Nino1 + 2, Nino3, and Nino4 regions were of order +1.0 °C/100 y. There were no significant trends in the cool season or annual minimum SST. Despite ocean warming, there were no significant trends in atoll Pa, in intra-annual or interannual variability over 7 decades for either SST or Pa, or in the relative strengths of warm/cool and wet/dry seasons. Extreme, large Pa only occurred after 1987, indicative of ocean warming. Extreme, small Pa happened throughout the period, suggesting no change in drought frequency. Correlations between 12-month P and SST were very strong, with historic rates of increases in Pa of around 1200 mm/y/°C, consistent with projections. The results indicate that the recharge of atoll groundwater will increase as oceans warm, but droughts will remain a major challenge.
Neural Similarity and Synchrony among Friends
Authors: Ma Chao , Liu Yi
Published: May 2024

Researchers have long recognized that friends tend to exhibit behaviors that are more similar to each other than to those of non-friends. In recent years, the concept of neural similarity or neural synchrony among friends has garnered significant attention. This body of research bifurcates into two primary areas of focus: the specificity of neural similarity among friends (vs. non-friends) and the situational factors that influence neural synchrony among friends. This review synthesizes the complex findings to date, highlighting consistencies and identifying gaps in the current understanding. It aims to provide a coherent overview of the nuanced interplay between social relationships and neural processes, offering valuable insights for future investigations in this field.
Are We on Course Yet? Functional Behavior Assessment and Behavior Intervention Plan Technical Adequacy in Schools
Authors: Iovannone Rose , Duble Moore Tobey , Williams Jeffrey M. , Sanchez Sindy , Kauk Nycole
Published: May 2024

It has been more than two decades since the Individuals with Disabilities Education Act (IDEA; 1997) included language about the use of functional behavior assessments (FBAs) and behavior intervention plans (BIPs) to address the challenging behaviors of students with disabilities in schools. It has been more than ten years since three technical adequacy studies were published that evaluated school-based FBAs’ and BIPs’ inclusion of essential components and found them to be significantly lacking. The aims of this study were to expand upon the previous research by (a) establishing the psychometric properties of the FBA/BIP Technical Adequacy Evaluation Tool (TATE), (b) evaluating the technical adequacy of 135 completed FBAs and 129 BIPs from 13 school districts across a single state, and (c) comparing the findings to previous studies. The results showed that (a) the TATE has moderate but acceptable internal consistency, excellent inter-rater reliability, and good content validity, (b) the technical adequacy scores of the evaluated products ranged between 40% and 50% of the total components, and (c) most of the BIPs had similar flaws to those seen in the previous research; however, improvement was noted in the FBA components. The implications for practice and suggestions for future research are discussed.
Innovative Methods to Improve the Seismic Performance of Precast Segmental and Hybrid Bridge Columns under Cyclic Loading
Authors: Badar Jahangir , Umar Tariq , Akbar Muhammad , Abbas Nadeem , Shahzad Qamar , Chen Weizhen , Arshid Muhammad Usman
Published: May 2024

This paper investigates the seismic performance of prefabricated segmental bridge columns (PSBCs) with hybrid post-tensioned tendons and energy dissipation (ED) bars under cyclic loading. PSBCs with unbonded and hybrid bonded prestressed tendons and columns incorporating ED bars are designed to improve the lateral strength, energy dissipation, and limit the residual drift. The PSBCs under cyclic loading were investigated using the three-dimensional finite element (FE) modeling platform ABAQUS. The FE model was calibrated against experimental results, with an overall error of less than 10%. The seismic performance of the proposed PSBCs was evaluated based on critical parameters, including lateral strength, residual plastic displacement, and the energy dissipation capacity. The results show that bonding the tendons in the plastic hinge region as opposed to the overall bonding along the column leads to a better cyclic performance. The lateral strength, and recentering abilities are further improved by bonding tendons up to 2/3 of the length in the plastic hinge region, along with 100–300 mm in the footing. It was also found that selecting a longitudinal length of ED bars crossing multiple precast segmental joints and having a circumferential spread of 70–90% of core concrete results in a higher bearing capacity and energy dissipation compared to ED bars crossing the single joint.
Understanding the Significance of Hypoxia-Inducible Factors (HIFs) in Glioblastoma: A Systematic Review
Authors: Begagić Emir , Bečulić Hakija , Džidić-Krivić Amina , Kadić Vukas Samra , Hadžić Semir , Mekić-Abazović Alma , Šegalo Sabina , Papić Emsel , Muchai Echengi Emmanuel , Pugonja Ragib , Kasapović Tarik , Kavgić Dalila , Nuhović Adem , Juković-Bihorac Fatima , Đuričić Slaviša , Pojskić Mirza
Published: May 2024

Background: The study aims to investigate the role of hypoxia-inducible factors (HIFs) in the development, progression, and therapeutic potential of glioblastomas. Methodology: The study, following PRISMA guidelines, systematically examined hypoxia and HIFs in glioblastoma using MEDLINE (PubMed), Web of Science, and Scopus. A total of 104 relevant studies underwent data extraction. Results: Among the 104 studies, global contributions were diverse, with China leading at 23.1%. The most productive year was 2019, accounting for 11.5%. Hypoxia-inducible factor 1 alpha (HIF1α) was frequently studied, followed by hypoxia-inducible factor 2 alpha (HIF2α), osteopontin, and cavolin-1. Commonly associated factors and pathways include glucose transporter 1 (GLUT1) and glucose transporter 3 (GLUT3) receptors, vascular endothelial growth factor (VEGF), phosphoinositide 3-kinase (PI3K)-Akt-mechanistic target of rapamycin (mTOR) pathway, and reactive oxygen species (ROS). HIF expression correlates with various glioblastoma hallmarks, including progression, survival, neovascularization, glucose metabolism, migration, and invasion. Conclusion: Overcoming challenges such as treatment resistance and the absence of biomarkers is critical for the effective integration of HIF-related therapies into the treatment of glioblastoma with the aim of optimizing patient outcomes.
Disease Control and Toxicity Outcomes after Stereotactic Ablative Radiation Therapy for Recurrent and/or Metastatic Cancers in Young-Adult and Pediatric Patients
Authors: Upadhyay Rituraj , Klamer Brett , Matsui Jennifer , Chakravarthy Vikram B. , Scharschmidt Thomas , Yeager Nicholas , Setty Bhuvana A. , Cripe Timothy P. , Roberts Ryan D. , Aldrink Jennifer H. , Singh Raj , Raval Raju R. , Palmer Joshua D. , Baliga Sujith
Published: May 2024

Background: Pediatric patients with metastatic and/or recurrent solid tumors have poor survival outcomes despite standard-of-care systemic therapy. Stereotactic ablative radiation therapy (SABR) may improve tumor control. We report the outcomes with the use of SABR in our pediatric solid tumor population. Methods: This was a single-institutional study in patients < 30 years treated with SABR. The primary endpoint was local control (LC), while the secondary endpoints were progression-free survival (PFS), overall survival (OS), and toxicity. The survival analysis was performed using Kaplan–Meier estimates in R v4.2.3. Results: In total, 48 patients receiving 135 SABR courses were included. The median age was 15.6 years (interquartile range, IQR 14–23 y) and the median follow-up was 18.1 months (IQR: 7.7–29.1). The median SABR dose was 30 Gy (IQR 25–35 Gy). The most common primary histologies were Ewing sarcoma (25%), rhabdomyosarcoma (17%), osteosarcoma (13%), and central nervous system (CNS) gliomas (13%). Furthermore, 57% of patients had oligometastatic disease (≤5 lesions) at the time of SABR. The one-year LC, PFS, and OS rates were 94%, 22%, and 70%, respectively. No grade 4 or higher toxicities were observed, while the rates of any grade 1, 2, and 3 toxicities were 11.8%, 3.7%, and 4.4%, respectively. Patients with oligometastatic disease, lung, or brain metastases and those who underwent surgery for a metastatic site had a significantly longer PFS. LC at 1-year was significantly higher for patients with a sarcoma histology (95.7% vs. 86.5%, p = 0.01) and for those who received a biological equivalent dose (BED10) > 48 Gy (100% vs. 91.2%, p = 0.001). Conclusions: SABR is well tolerated in pediatric patients with 1-year local failure and OS rates of <10% and 70%, respectively. Future studies evaluating SABR in combination with systemic therapy are needed to address progression outside of the irradiated field.
Aesthetic Evaluation of Facial Scars in Patients Undergoing Surgery for Basal Cell Carcinoma: A Prospective Longitudinal Pilot Study and Validation of POSAS 2.0 in the Lithuanian Language
Authors: Kučinskaitė Alvija , Stundys Domantas , Gervickaitė Simona , Tarutytė Gabrielė , Grigaitienė Jūratė , Tutkuvienė Janina , Jančorienė Ligita
Published: May 2024

Facial basal cell carcinoma (BCC) surgery enhances the quality of life (QoL) but leaves patients with inferior QoL, presumably caused by scarring, emphasizing the need to understand post-surgery aesthetic satisfaction. This study aimed to validate the Lithuanian version of the Patient and Observer Scar Assessment Scale (POSAS) 2.0 and utilise it to identify scar evaluation differences and correlations among POSAS scores and specific aesthetic facial regions, age, gender, surgery types, and short- and long-term QoL. Employing a prospective longitudinal design, 100 patients with facial scars after surgical BCC removal were enrolled. The validation phase confirmed the translated POSAS 2.0 psychometric properties, while the pilot phase used statistical analyses to compare scores among demographic and clinical groups and evaluate correlations between scar assessment and QoL. The findings indicate that the translated Lithuanian version of POSAS 2.0 exhibits good psychometric properties, revealing insights into aesthetic satisfaction with post-surgical facial scars and their impact on QoL. The Lithuanian version of the POSAS 2.0 was established as a valid instrument for measuring post-surgical linear scars. QoL with scar assessment statistically significantly correlates, 6 months after surgery, with worse scores, particularly notable among women, younger patients, and those with tumours in the cheek region.
Total Neoadjuvant Therapy for Rectal Cancer: Which Regimens to Use?
Authors: Ochiai Kentaro , Bhutiani Neal , Ikeda Atsushi , Uppal Abhineet , White Michael , Peacock Oliver , Messick Craig , Bednarski Brian , You Yi-Qian , Skibber John , Chang George , Konishi Tsuyoshi
Published: May 2024

Total neoadjuvant therapy (TNT) is a novel strategy for rectal cancer that administers both (chemo)radiotherapy and systemic chemotherapy before surgery. TNT is expected to improve treatment compliance, tumor regression, organ preservation, and oncologic outcomes. Multiple TNT regimens are currently available with various combinations of the treatments including induction or consolidation chemotherapy, triplet or doublet chemotherapy, and long-course chemoradiotherapy or short-course radiotherapy. Evidence on TNT is rapidly evolving with new data on clinical trials, and no definitive consensus has been established on which regimens to use for improving outcomes. Clinicians need to understand the advantages and limitations of the available regimens for multidisciplinary decision making. This article reviews currently available evidence on TNT for rectal cancer. A decision making flow chart is provided for tailor-made use of TNT regimens based on tumor location and local and systemic risk.
Targeting Neoantigens in Pancreatic Ductal Adenocarcinoma
Authors: Singh Gurkaranjot , Kutcher Drew , Lally Rajeshwar , Rai Vikrant
Published: May 2024

Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer and is currently the third leading cause of cancer-related death in the United States after lung and colon cancer. PDAC is estimated to be the second leading cause of cancer-related death by 2030. The diagnosis at a late stage is the underlying cause for higher mortality and poor prognosis after surgery. Treatment resistance to chemotherapy and immunotherapy results in recurrence after surgery and poor prognosis. Neoantigen burden and CD8+ T-cell infiltration are associated with clinical outcomes in PDAC and paucity of neoantigen-reactive tumor-infiltrating lymphocytes may be the underlying cause for treatment resistance for immunotherapy. This suggests a need to identify additional neoantigens and therapies targeting these neoantigens to improve clinical outcomes in PDAC. In this review, we focus on describing the pathophysiology, current treatment strategies, and treatment resistance in PDAC followed by the need to target neoantigens in PDAC.
Lymphomas of the Vulva: A Review of the MITO Rare Cancer Group
Authors: Magazzino Francescapaola , Aristei Cynthia , Passarelli Anna , Pierini Antonio , De Giorgi Ugo , Martinello Ruby , Domenici Lavinia , Pignata Sandro , Mangili Giorgia , Cormio Gennaro
Published: May 2024

Since they are very rare tumors, lymphomas of the vulva are often not properly recognized. Patients with vulvar lymphoma are generally elderly and the classical manifestation of the disease is a vulvar mass. No significant age differences have been found between primary and secondary lymphoma. To make a correct diagnosis, it is therefore necessary to use not only histological examination but also the genetic and molecular profile in order to establish optimal therapeutic management. Literature analysis confirm the good prognosis of this disease.
Qualitative Classification of Late Systemic Symptoms in Head and Neck Cancer Survivors
Authors: Schoenberg Poppy , Wulff-Burchfield Elizabeth , Schlundt David , Bonnet Kemberlee , Dietrich Mary , Murphy Barbara
Published: May 2024

Improved rates of cancer control have increased the head and neck cancer survivor population. Cancer survivorship clinics are not widely available in the USA, and longitudinal supportive care for patients undergoing multimodal therapy has not advanced at a pace commensurate with improvements in cancer control. Consequently, a large head and neck cancer survivor population whose quality of life may be chronically and/or permanently diminished presently exists. This lack of awareness perpetuates under-recognition and under-investigation, leaving survivors’ (mostly detrimental) experiences largely uncharted. We conducted a qualitative exploration of survivors’ experiences, aiming to unpack the profound impact of late systemic symptoms on daily life, encompassing work, relationships, and self-identity in the head and neck cancer survivor community. The study included 15 remitted head and neck survivors, ≥12 months from their final treatment, who participated in semi-structured interviews conducted by a medical oncologist. Data analysis comprised qualitative thematic analysis, specifically inductive hierarchical linear modeling, enriched by a deductive approach of anecdotal clinical reporting. Results highlighted that 43.36% of all quotation material discussed in the interviews pertained to chronic emotion disturbance with significant implications for other domains of life. A central symptom cluster comprised impairments in mood/emotions, daily activity, and significant fatigue. Dysfunction in sleep, other medical conditions, and cognitive deficits comprised a secondary cluster. Physical dysfunctionality, encompassing pain, appetite, and eating, and alterations in experienced body temperature, constituted a tertiary cluster, and perhaps were surprisingly the least discussed symptom burden among head and neck cancer survivors. Symptoms causing heightened long-term survivor burden may be considered epiphenomenal to central physical dysfunctionality, albeit being presently the least represented in cancer survivor care programs. Moving forward, the development of targeted and multi-dimensional treatment programs that encompass physical, psychosocial, and spiritual domains are needed to increase clinical specificity and effective holistic long-term solutions that will foster a more compassionate and informed future of care for the cancer survivorship community.
Medication Risks and Their Association with Patient-Reported Outcomes in Inpatients with Cancer
Authors: Günther Maximilian , Schuler Markus , Hentschel Leopold , Salm Hanna , Schmitz Marie-Therese , Jaehde Ulrich
Published: May 2024

Background: We aimed to assess medication risks and determine factors influencing the health-related quality of life (HRQOL) in cancer inpatients. Methods: A retrospective analysis was conducted to identify drug-related problems (DRPs) based on medication reviews, including patient-reported outcomes (PROs). Multiple linear regression analyses were performed to identify sociodemographic, disease-related, and drug therapy-related factors influencing changes from hospital admission to discharge in the scales of the EORTC QLQ-C30 questionnaire. Results: A total of 162 inpatients with various hematological and solid cancer diseases was analyzed. Patients received a mean of 11.6 drugs and 92.6% of patients exhibited polymedication resulting in a mean of 4.0 DRPs per patient. Based on PRO data, 21.5% of DRPs were identified. Multiple linear regression models described the variance of the changes in global HRQOL and physical function in a weak-to-moderate way. While drug therapy-related factors had no influence, relapse status and duration of hospital stay were identified as significant covariates for global HRQOL and physical function, respectively. Conclusion: This analysis describes underlying DRPs in a German cancer inpatient population. PROs provided valuable information for performing medication reviews. The multiple linear regression models for global HRQOL and physical function provided explanations for changes during hospital stay.
The Role of Insulin-like Growth Factor Binding Protein (IGFBP)-2 in DNA Repair and Chemoresistance in Breast Cancer Cells
Authors: Mohammedali Alaa , Biernacka Kalina , Barker Rachel M. , Holly Jeff M. P. , Perks Claire M.
Published: May 2024

The role if insulin-like growth factor binding protein-2 (IGFBP-2) in mediating chemoresistance in breast cancer cells has been demonstrated, but the mechanism of action is unclear. This study aimed to further investigate the role of IGFBP-2 in the DNA damage response induced by etoposide in MCF-7, T47D (ER+ve), and MDA-MB-231 (ER-ve) breast cancer cell lines. In the presence or absence of etoposide, IGFBP-2 was silenced using siRNA in the ER-positive cell lines, or exogenous IGFBP-2 was added to the ER-negative MDA-MB-231 cells. Cell number and death were assessed using trypan blue dye exclusion assay, changes in abundance of proteins were monitored using Western blotting of whole cell lysates, and localization and abundance were determined using immunofluorescence and cell fractionation. Results from ER-positive cell lines demonstrated that upon exposure to etoposide, loss of IGFBP-2 enhanced cell death, and this was associated with a reduction in P-DNA-PKcs and an increase in γH2AX. Conversely, with ER-negative cells, the addition of IGFBP-2 in the presence of etoposide resulted in cell survival, an increase in P-DNA-PKcs, and a reduction in γH2AX. In summary, IGFBP-2 is a survival factor for breast cancer cells that is associated with enhancement of the DNA repair mechanism.
Phospholipid Acyltransferases: Characterization and Involvement of the Enzymes in Metabolic and Cancer Diseases
Authors: Korbecki Jan , Bosiacki Mateusz , Pilarczyk Maciej , Gąssowska-Dobrowolska Magdalena , Jarmużek Paweł , Szućko-Kociuba Izabela , Kulik-Sajewicz Justyna , Chlubek Dariusz , Baranowska-Bosiacka Irena
Published: May 2024

This review delves into the enzymatic processes governing the initial stages of glycerophospholipid (phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine) and triacylglycerol synthesis. The key enzymes under scrutiny include GPAT and AGPAT. Additionally, as most AGPATs exhibit LPLAT activity, enzymes participating in the Lands cycle with similar functions are also covered. The review begins by discussing the properties of these enzymes, emphasizing their specificity in enzymatic reactions, notably the incorporation of polyunsaturated fatty acids (PUFAs) such as arachidonic acid and docosahexaenoic acid (DHA) into phospholipids. The paper sheds light on the intricate involvement of these enzymes in various diseases, including obesity, insulin resistance, and cancer. To underscore the relevance of these enzymes in cancer processes, a bioinformatics analysis was conducted. The expression levels of the described enzymes were correlated with the overall survival of patients across 33 different types of cancer using the GEPIA portal. This review further explores the potential therapeutic implications of inhibiting these enzymes in the treatment of metabolic diseases and cancer. By elucidating the intricate enzymatic pathways involved in lipid synthesis and their impact on various pathological conditions, this paper contributes to a comprehensive understanding of these processes and their potential as therapeutic targets.
Mineralogical Crystallography Volume III
Authors: Gurzhiy Vladislav V.
Published: May 2024

The United Nations and UNESCO designated 2014 as the International Year of Crystallography, in which the scientific community celebrated the centenary of the discovery of X-ray diffraction [...]
Frozen Section of Placental Membranes and Umbilical Cord: A Valid Diagnostic Tool for Early-Onset Neonatal Sepsis Management
Authors: Parrella Veronica , Paudice Michele , Pittaluga Michela , Allodi Alessandra , Fulcheri Ezio , Buffelli Francesca , Barra Fabio , Ferrero Simone , Arioni Cesare , Vellone Valerio Gaetano
Published: May 2024

Early-onset neonatal sepsis (EONS), a serious infection in newborns within 3 days, is challenging to diagnose. The current methods often lack accuracy, leading to unnecessary antibiotics or delayed treatment. This study investigates the role of the frozen section examination of placental membranes and umbilical cord (FSMU) to improve EONS diagnosis in the daily lab practice. This retrospective study reviewed data from 59 neonates with EONS risk factors who underwent FSMU according to our institutional protocol. Concordance between the FSMU and the Final Pathological Report (FPR) was assessed. The FSMU demonstrated a high concordance (Kappa = 0.88) for funisitis diagnosis, with excellent accuracy (98.3%). A moderate concordance was observed for chorioamnionitis stage and grade. The FSMU shows promise as a rapid and accurate tool for diagnosing EONS, particularly for funisitis. This study suggests that the FSMU could be a valuable tool for EONS diagnosis, enabling a more judicious antibiotic use and potentially improving outcomes for newborns.
Clinical and Analytical Comparison of Monoclonal and Polyclonal Immunoassays for Fecal Pancreatic Elastase
Authors: Lenicek Krleza Jasna , Aralica Merica , Milevoj Kopcinovic Lara , Zrinski Topic Renata
Published: May 2024

Background: Numerous immunoassays have been commercialized to determine pancreatic elastase (PE) in feces in screening for exocrine pancreatic insufficiency (EPI), but how the different assays compare to one another is controversial, especially in the context that all methods use the same cut-off values for interpreting the results obtained on the presence or absence of EPI or the degree of insufficiency if it is present. Our aim was to analytically verify a new method for determining PE, compare the results with a previous method, and verify the declared cut-off values for interpretation of the results. Methods: PE in the stool was assayed using a previous monoclonal enzyme-linked immunosorbent assay (“ScheBo ELISA”) and a new polyclonal particle-enhanced turbidimetric immunoassay (“Bühlmann PETIA”). The direct method comparison of two immunoassays was performed in 40 samples. Clinical comparisons were conducted against each other for the binary determination of “abnormal/normal” elastase levels and the three-way determination of “severe/moderate/no” EPI in 56 samples. The indirect comparison method used external quality assessment (EQA) data to compare the monoclonal and polyclonal immunoassays for PE, and additionally compare the monoclonal ScheBo ELISA to a monoclonal chemiluminescence immunoassay (“DiaSorin CLIA”). Results: Precision in the series and intra-laboratory precision for Bühlmann PETIA met the manufacturer’s specifications for the concentration range of limit/lower values and the range of normal values. The Bühlmann PETIA immunoassay on different analytical platforms yielded comparable results and nearly perfect agreement in the case of three-way classification (kappa = 0.89 with 95%CI from 0.79 to 1.00. ScheBo ELISA tends to generate higher values of pancreatic elastase than the Bühlmann PETIA; agreement between the methods was moderate in the case of binary classification (kappa = 0.43; 95% CI 0.25 to 0.62), and substantial in the case of three-way classification (kappa = 0.62; 95% CI 0.50 to 0.75). EQA data analysis showed a statistically significant difference between ScheBo ELISA and Bühlmann PETIA peer groups (p = 0.031), as well as the DiaSorin CLIA and ScheBo ELISA peer groups (p = 0.010). Conclusion: The ScheBo ELISA and Bühlmann PETIA do not appear to be commutable in the analytical and clinical context. Our data address a discordance between different mono- and polyclonal immunoassays for pancreatic elastase and the potential of misclassification using its universal cut-off values in screening suspected patients for exocrine pancreatic insufficiency.
A Comprehensive Review of the Global Epidemiology, Clinical Management, Socio-Economic Impacts, and National Responses to Long COVID with Future Research Directions
Authors: Song Xiufang , Song Weiwei , Cui Lizhen , Duong Tim Q. , Pandy Rajiv , Liu Hongdou , Zhou Qun , Sun Jiayao , Liu Yanli , Li Tong
Published: May 2024

Background: Long COVID, characterized by a persistent symptom spectrum following SARS-CoV-2 infection, poses significant health, social, and economic challenges. This review aims to consolidate knowledge on its epidemiology, clinical features, and underlying mechanisms to guide global responses; Methods: We conducted a literature review, analyzing peer-reviewed articles and reports to gather comprehensive data on long COVID’s epidemiology, symptomatology, and management approaches; Results: Our analysis revealed a wide array of long COVID symptoms and risk factors, with notable demographic variability. The current understanding of its pathophysiology suggests a multifactorial origin yet remains partially understood. Emerging diagnostic criteria and potential therapeutic strategies were identified, highlighting advancements in long COVID management; Conclusions: This review highlights the multifaceted nature of long COVID, revealing a broad spectrum of symptoms, diverse risk factors, and the complex interplay of physiological mechanisms underpinning the condition. Long COVID symptoms and disorders will continue to weigh on healthcare systems in years to come. Addressing long COVID requires a holistic management strategy that integrates clinical care, social support, and policy initiatives. The findings underscore the need for increased international cooperation in research and health planning to address the complex challenges of long COVID. There is a call for continued refinement of diagnostic and treatment modalities, emphasizing a multidisciplinary approach to manage the ongoing and evolving impacts of the condition.
Neurosurgical Intervention for Nerve and Muscle Biopsies
Authors: Mohamed Ali A. , Caussat Thomas , Mouhawasse Edwin , Ali Rifa , Johansen Phillip M. , Lucke-Wold Brandon
Published: May 2024

(1) Background: Neurologic and musculoskeletal diseases represent a considerable portion of the underlying etiologies responsible for the widely prevalent symptoms of pain, weakness, numbness, and paresthesia. Because of the subjective and often nonspecific nature of these symptoms, different diagnostic modalities have been explored and utilized. (2) Methods: Literature review. (3) Results: Nerve and muscle biopsy remains the gold standard for diagnosing many of the responsible neurological and musculoskeletal conditions. However, the need for invasive tissue sampling is diminishing as more investigations explore alternative diagnostic modalities. Because of this, it is important to explore the current role of neurosurgical intervention for nerve and muscle biopsies and its current relevance in the diagnostic landscape of neurological and musculoskeletal disorders. With consideration of the role of nerve and muscle biopsy, it is also important to explore innovations and emerging techniques for conducting these procedures. This review explores the indications and emerging techniques for neurological intervention for nerve and muscle biopsies. (4) Conclusions: The role of neurosurgical intervention for nerve and muscle biopsy remains relevant in diagnosing many neurological and musculoskeletal disorders. Biopsy is especially relevant as a supportive point of evidence for diagnosis in atypical cases. Additionally, emerging techniques have been explored to guide diagnostics and biopsy, conduct less invasive biopsies, and reduce risks of worsening neurologic function and other symptoms secondary to biopsy.
A Magnetic Resonance Spectroscopy Study on Polarity Subphenotypes in Bipolar Disorder
Authors: Argyropoulos Georgios D. , Christidi Foteini , Karavasilis Efstratios , Bede Peter , Velonakis Georgios , Antoniou Anastasia , Seimenis Ioannis , Kelekis Nikolaos , Smyrnis Nikolaos , Papakonstantinou Olympia , Efstathopoulos Efstathios , Ferentinos Panagiotis
Published: May 2024

Although magnetic resonance spectroscopy (MRS) has provided in vivo measurements of brain chemical profiles in bipolar disorder (BD), there are no data on clinically and therapeutically important onset polarity (OP) and predominant polarity (PP). We conducted a proton MRS study in BD polarity subphenotypes, focusing on emotion regulation brain regions. Forty-one euthymic BD patients stratified according to OP and PP and sixteen healthy controls (HC) were compared. 1H-MRS spectra of the anterior and posterior cingulate cortex (ACC, PCC), left and right hippocampus (LHIPPO, RHIPPO) were acquired at 3.0T to determine metabolite concentrations. We found significant main effects of OP in ACC mI, mI/tNAA, mI/tCr, mI/tCho, PCC tCho, and RHIPPO tNAA/tCho and tCho/tCr. Although PP had no significant main effects, several medium and large effect sizes emerged. Compared to HC, manic subphenotypes (i.e., manic-OP, manic-PP) showed greater differences in RHIPPO and PCC, whereas depressive suphenotypes (i.e., depressive-OP, depressive-PP) in ACC. Effect sizes were consistent between OP and PP as high intraclass correlation coefficients (ICC) were confirmed. Our findings support the utility of MRS in the study of the neurobiological underpinnings of OP and PP, highlighting that the regional specificity of metabolite changes within the emotion regulation network consistently marks both polarity subphenotypes.
Heart Failure with Mid-Range or Mildly Reduced Ejection Fraction in the Era of Sodium–Glucose Co-Transporter 2 Inhibitors: Do We Now Provide Better Care for the “Middle Child of HF”? Real-World Experience from a Single Clinical Centre
Authors: Viđak Marin , Kursar Jelena , Bodrožić Džakić Poljak Tomislava , Letilović Tomislav , Ćatić Jasmina , Ivanović Mihajlović Vanja , Zebić Mihić Petra , Manola Šime , Jurin Ivana
Published: May 2024

Heart failure (HF) with mid-range or mildly reduced ejection fraction (HFmrEF) is a separate clinical entity in the HF spectrum, with a left ventricular ejection fraction ranging from 40 to 49%. While sodium glucose co-transporter 2 inhibitors have become the cornerstone therapy for the entire HF spectrum, there are a few clinical trials of HFmrEF. This prospective observational study was conducted at Dubrava University Hospital, Zagreb, Croatia, from May 2021 to October 2023. We recruited 137 participants diagnosed with HFmrEF at admission. The majority were male, with a median age of 72 and overweight. A total of 110 participants were followed for 6 months and LVEF remained the same in the majority of patients (n = 62, 56.4%), improved in 32 patients (29.1%), and decreased in 3 patients (2.73%). A total of 64 participants were followed for 12 months: 39 remained the same (60.94%) and 25 improved. There were 13 deaths in (9.5%). While the empagliflozin group had a lower BMI at 6-month- and lower HbA1c at 12-month follow-up, there were no differences in death, HF hospitalizations, ER visits, or urinary tract infections in between groups. Despite recent and daily advances in the treatment of all HF phenotypes, HFmrEF still represents a challenge in everyday clinical practice.
A Lower Remote Dielectric Sensing Value Was Associated with Hypovolemia and Worse Clinical Outcomes
Authors: Imamura Teruhiko , Izumida Toshihide , Narang Nikhil , Kinugawa Koichiro
Published: May 2024

Background: Remote dielectric sensing (ReDS) systems can estimate the amount of lung fluid non-invasively and easily without expert techniques. The correlation between the elevated ReDS value and other modalities that estimate pulmonary congestion has been validated. The clinical implications of lower ReDS values, which may indicate hypovolemia, remain unknown. Methods: A total of 138 patients who were hospitalized for various cardiovascular-related problems and underwent ReDS value measurements at the index discharge in a blinded manner to the attending clinicians were eligible for inclusion. Patients with ReDS values > 30%, indicating the presence of pulmonary congestion, were excluded. The prognostic impact of lower ReDS values on all-cause readmission after index discharge was evaluated. Results: A total of 97 patients were included. The median age was 78 years, and 48 were men. The median ReDS value at index discharge was 26% (23%, 27%). A lower ReDS value correlated with smaller inferior vena cava maximum diameters (r = 0.46, p < 0.001) and higher blood urea nitrogen/creatinine ratios (r = −0.35, p < 0.001). A lower ReDS value (≤25%) was associated with a risk of all-cause readmissions with an unadjusted hazard ratio of 2.68 (95% confidence interval 1.09–6.59, p = 0.031) and an adjusted hazard ratio of 2.30 (95% confidence interval 0.92–5.78, p = 0.076). Its calculated cutoff of 25% significantly stratified the cumulative incidence of the primary outcome (36% versus 17%, p = 0.038). Conclusions: A lower ReDS value may indicate hypovolemia and be associated with the risk of all-cause readmission in patients hospitalized for cardiovascular diseases.
Language Attitudes in Australia: Results from a Nationwide Survey
Authors: Diskin-Holdaway Chloé , Escudero Paola
Published: May 2024

Recent research on attitudes to Australian English (AusE) shows that there is a general increase in its acceptance, legitimacy, and endonormativity. However, a certain “cultural cringe” exists, particularly when “broad” AusE is seen as representative of the variety. A significant gap in the literature is how the perceptions and usage of AusE may change as the population becomes more diverse. This paper presents findings of an online survey of language attitudes towards AusE with 661 respondents across Australia, over a third of whom were born overseas. Overall, there is minimal evidence of a standard language ideology, with 80% of respondents reporting having an accent to some degree. Almost half of respondents report occasionally or frequently changing their accents due to context, interlocutor, or making themselves understood. When asked to rate AusE along six traits on a seven-point scale, the traits of educatedness, professionalism, and attractiveness were consistently centered on neutral. For friendliness and likeability, the majority skewed towards neutral and positive. For the trait of clarity, there was a greater range of responses, but overall, 50% of respondents found AusE to be somewhat, moderately, or really clear. These findings further our understanding of attitudes and ideologies in Australia’s increasingly diverse language ecology.