bluuebunny/crossref_metadata_2025 huggingface dataset:
Screening and Identification of Nanobody against Inhibin α-Subunit from a Camelus Bactrianus Phage Display Library
Authors: Ma Jifu , Khalembek Kezerbek , Xie Jingang , Kadyken Rizabek , Baibatshanov Mukhtar , Jia Haotian , Bodai Bakhet , Kazkhan Oralhazi
Published: March 2023

The inhibin α-subunit is a member of the transforming growth factor family that influences animal reproduction. The purpose of this study was to obtain nanobodies from the phage antibody library constructed by us that can specifically bind to inhibin α-subunit. Such nanobodies can indirectly increase the level of follicle stimulating hormone (FSH) and promote follicular maturation. In this study, Xinjiang Bactrian camel was immunized with prokaryote-expressed inhibin α protein, and the camel phage nanobody display library was prepared by nest polymerase chain reaction (PCR). The nanobodies specifically binding to inhibin α-subunit in the library were screened by three rounds of immunoaffinity screening and phage enzyme-linked immunosorbent assay (phage ELISA). The functions of the selected nanobodies were identified using molecular simulation docking, ELISA affinity test, and sheep immunity test. The results revealed that a nanobody display library was successfully constructed with a capacity of 1.05 × 1012 CFU, and four inhibin-α-subunit-specific nanobodies with an overall similarity of 69.34% were screened from the library, namely, Nb-4, Nb-15, Nb-26, and Nb-57. The results of molecular simulation docking revealed that four types of nanobodies were linked to inhibin-α protein mainly through hydrophobic bonds. Immune tests revealed that the immunity of nanobody Nb-4 could effectively inhibit the level of sheep inhibin A/B, and the nanobody Nb-4 could significantly improve the FSH level in sheep. In summary, four nanobodies with biological function were successfully screened from the constructed antiinhibin α-subunit nanobody library using phage display technique. To the best of our knowledge, this is a new reproductive immunomodulatory pathway of inhibin α-subunit, which may change the secretion of FSH in the ovary, thus changing the estrous cycle of organisms. This study provided a reference for the application of nanobodies in reproductive immunology.
Breast surgery for patients with de novo metastatic breast cancer: A meta-analysis
Authors: Ren Chongxi , Sun Jianna , Kong Lingjun , Wang Hongqiao
Published: March 2023

Background The role of breast surgery in the treatment of patients with de novo metastatic breast cancer (dnMBC) remains controversial, with conflicting trial results. We did a meta-analysis to comprehensively investigate and assess whether breast surgery is associated with survival and quality of life outcomes in patients with dnMBC.
Methods We systematically searched PubMed, Embase, Google Scholar, Scopus, and Web of Science, from database inception to March 30, 2022, for randomised controlled trials (RCTs) that compared breast surgery or locoregional therapy with non-surgical treatment based on systemic therapy for managing dnMBC. We also reviewed abstracts and presentations from major conference proceedings. We excluded non-randomised trials and considered only papers published in English. The primary outcomes were overall survival (OS), locoregional progression-free survival (LPFS), distant progression-free survival (DPFS), and quality of life (QoL).The quality of RCTs was appraised with the Cochrane Collaboration risk of bias tool. Random-effects model was used to calculate the effect sizes of included RCTs.The quality of evidence was evaluated with the Grading of Recommendations Assessment, Development and Evaluation approach. Data analysis was performed with STATA version 17.0 (Statacorp, college station, Tex).
Results A total of 1018 women from seven randomized clinical trials were included in the analysis. Pooled analyses revealed that compared with systemic therapy, breast surgery was not associated with beneficial outcomes in OS (hazard ratio [HR], 0.87; 95% CI, 0.68 to 1.11), DPFS (HR, 0.96; 95% CI, 0.41 to 2.22), or QoL (standardized mean difference [SMD], -0.26; 95% CI,-0.58 to 0.06), but was associated with a benefit in LPFS (HR, 0.36; 95% CI, 0.13 to 0.96).These findings were consistent in subgroup analyses of the timing of surgery, site and number of metastases and tumor molecular subtype.The evidence grade was moderate because of the substantial heterogeneity among studies.
Conclusions Based on the RCTs evidence, we found that breast surgery may benefit locoregional control but does not prolong OS and improve QoL in patients with dnMBC.
Fine-Grained Bird Image Classification Based on Counterfactual method of Vision Transformer Model
Authors: Chen Tianhua , Li Yanyue , Qiao Qinghua
Published: March 2023

Identifying bird targets, especially scarce birds, is essential to reflect the level of ecological protection and diversity. A fine-grained bird identification model with hierarchical feature fusion and counterfactual feature selection is proposed due to the problems of similar features, slight differences, and difficulty of identification among different birds. The model comprises a feature extraction network, a hierarchical feature fusion module, and a counterfactual feature selection module. The feature extractor extracts local area image features and global image features. The hierarchical feature fusion module fuses fine-grained information from the shallow layers of the network and semantic information from the current layer. The counterfactual feature enhancement module sifts out the distinguishing features fed to the classifier by counterfactual intervention. The experimental results show that the method can achieve 91.9% and 91.4% accuracy on two available datasets, CUB-200-2011 and NABirds, respectively, which is higher than the current mainstream fine-grained bird recognition algorithms and shows excellent classification performance.
Comparative Biology and Life Tables of Sugarcane Aphid Melanaphis Sacchari (Hemiptera: Aphididae) From Guanajuato, Mexico, at Different Temperatures
Authors: Peña-Martínez Rebeca , Lomeli-Flores J. Refugio , Bujanos-Muñiz Rafael , Salas-Monzón Raquel , Hernández-Torres Oscar Eduardo , Marín-Jarillo Antonio , Ibarra Jorge E. , Vanegas-Rico Juan Manuel , Muñoz-Viveros Ana Lilia
Published: March 2023

The Sugarcane aphid, Melanaphis sacchari (Zehntner, 1897) is the most important pest in sorghum crops of USA and Mexico. In northern Mexico and other regions, as Guanajuato and Morelos, reduced over 30% of the cultivated area of sorghum between 2016 and 2019. This study provides basic information that supports the Integrated Management of this insect. Research used biological material (parthenogenetic forms) from Guanajuato, Mexico; reared in foliar agar-disc of Sorghum bicolor VAR. UPM-219, at bioclimatic chamber under different temperatures: 5, 10, 15, 20, 25, 30, 35 and 40°C. The highest mortalities occurred in extremes temperatures: 5°C (35%), 35°C (45%) and 40°C (100%). At low temperature (5°C) there was no reproduction and the pre-reproductive period continued 62.5 days, allowing the insects to survive on average 88.2 days. At the highest temperature (40°C), nymph 1 died in 0.9 days. While at 20°C, M. sacchari produced a supernumerary N5 stage that prolonged the development to 7.1 days. The longest reproductive period was 33.2 days (0.6 nymphs/day) to 10°C, in contrast to 4.1 days (0.4 nymphs/day) to 35°C; the longest post-reproductive period (22.4 days) was obtained at 10°C and the smallest (4.2 days) at 35°C. Highest average fertility (79.06 nymphs) was reached at 25°C. Theoretical thermal thresholds was 2.0° and 40°C; and the heat units t required for each generation were 158.9. Population parameters show that 25°C is the optimal temperature for this aphid Ro (79.06) and Rm (0.44) T (10.01) DT (1.59 and λ (1.55).
Identification of key genes associated with breast cancer radiotherapy sensitivity based on the stromal-immune score and analysis of the WGCNA and ceRNA network
Authors: Sun Xiaoyue , Wu Chihua , Zhang Shengwei , Zhao Xinchen , Wang Xiaoshan
Published: March 2023

Breast cancer is a highly malignant disease worldwide. Among the numerous treatment options for breast cancer, radiotherapy is one of the commonly used treatments, while there is currently no sufficient molecular biomarkers to predict prognosis and guide its application. The tumor microenvironment (TME) is an important factor affecting tumor biological function, and changes in its composition are equally relevant to tumor progression and prognosis during radiotherapy. Here, we performed bioinformatic analyses using data obtained from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases to screen for molecular biomarkers related to TME that may influence radiotherapy sensitivity. By combining immune scores and stromal scores calculated as well as performing weighted co-expression network analysis (WGCNA), we identified key modules and hub genes to construct competing endogenous RNA (ceRNA) networks. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis showed that genes of the PI3K-AKT pathway in the blue module were significantly enriched. Among hub genes in the blue module, we further found that the expression levels of COL1A1, COL1A2, COL6A3, THBS2 and PDGFRB were negatively associated with radiotherapy sensitivity. These findings may provide new insights into the mechanisms of radiotherapy sensitivity in breast cancer patients, offering hope for the discovery of new therapeutic targets.
The recombinome of IKZF1 deletions in B-ALL
Authors: Lopes Bruno , Meyer Claus , Bouzada Heloysa , Külp Marius , Maciel Ana Luiza , Larghero Patrizia , Barbosa Thayana , Poubel Caroline , Blunck Caroline , Venn Nicola , Dalla-Pozza Luciano , Barbaric Draga , Palmi Chiara , Fazio Grazia , Saitta Claudia , Aguiar Thais , Lins Mecneide , Ikoma-Colturato Maura , Schramm Marcia , Chapchap Eduardo , Cazzaniga Giovanni , Sutton Rosemary , Marschalek Rolf , Emerenciano Mariana
Published: March 2023

IKZF1 deletions are associated with an increased risk of relapse in B-cell precursor acute lymphoblastic leukemia (B-ALL), and their accurate detection has great clinical impact. Here, we included four international cohorts of pediatric and adult patients with B-ALL, and reviewed literature to illustrate the recombination map of IKZF1 deletions, with a focus at non-recurrent deletions. We provide a substantial basis for the improvement of diagnostic methods based on MLPA and multiplex PCR for the identification of IKZF1 deletions, and also demonstrate that rare IKZF1 deletions increase the incidence of relapse in these patients. Of note, non-recurrent deletions comprised a wide range of alterations, but the majority were Δ1 and Δ1–3. They were often associated with reciprocal IKZF1 fusions. So far, a total of 23 IKZF1 gene fusions were identified in B-ALL. We also verified the occurrence of the heptamer sequence (E-value: 9.9 x 10− 9) and an enrichment of GC nucleotides (71% versus 56%; P value = 4.9 x 10− 3) exclusively within breakpoint clusters, suggesting that RAG recombination and TdT activity may promote the majority of IKZF1 deletions, although rare types of alterations may be associated with other molecular mechanism of leukemogenesis, such as microhomology-mediated end joining.
Selection of Representative General Circulation Models Under Climatic Uncertainty for Western North America
Authors: Mahjour Seyed Kourosh , Liguori Giovanni , Faroughi Salah A.
Published: March 2023

Studies on the impacts of climate change rely on the global projections of the future climate made by General Circulation Models (GCMs). Despite the availability of a growing number of climate model outputs and the continual development of their process representations, considerable uncertainty cannot be eliminated from their future climate projections. This circumstance, combined with other variables, e.g., time and computing limitations, necessitates the selection of appropriate representative GCM-runs (RGCM-runs), reflecting the past and projected future climate, to assess the effects of climate change on different infrastructures. This study is undertaken to select RGCM-runs for Western North America (WNA) based on their ability to simulate past climates between 1981 and 2005 and climatic changes between two 30-year periods, 2071–2100 and 1981–2010, under two representative concentration pathways (RCPs) scenarios, RCP4.5 and RCP8.5. GCMs and their various runs are independently treated as standalone potentials in the selection process, and the initial pool (i.e., full-set) for RCP4.5 and RCP8.5 include 105 and 77 GCM-runs, respectively. We examine GCM-runs reduction by evaluating RGCM-runs performance on three criteria: (i) capturing changes in the climatology of monthly mean precipitation and air temperature, (ii) capturing changes in the monthly mean extreme indices, and (iii) matching the historical and reference datasets (i.e., history matching). For the first two criteria, we employ an envelope-based selection technique, and for the last criterion, gleaning the final RGCM-runs, we present a multi-objective distance-based approach comparing the GCM-runs to reference data sets (i.e., monthly average of temperature and precipitation). This framework selects four RGCM-runs for each RCP to represent the full-set and capture the full range of climatic conditions, including wet-warm, wet-cold, dry-warm, and dry-cold scenarios, which represent the extremes of the climatic spectrum. The results demonstrate that the RGCM-runs can simulate previous climatic conditions and projected changes in key climate variables in WNA, such as temperature and precipitation. This indicates that the selected RGCM-runs are suitable for conducting climate impact assessments and developing adaptation plans for the WNA region.
On the properties of multivariate isotropic random fields on the ball
Authors: Cleanthous Galatia
Published: March 2023

We consider multivariate isotropic random fields on the ball Bd. We first study their regularity properties in terms of Sobolev spaces. We further derive conditions guaranteeing the Hölder continuity of their covariance kernels and we prove the existence of sample Hölder continuous modifications for Gaussian random fields. Furthermore, we measure the error of truncated approximations of the corresponding series' representations. Moreover our developments are supported by numerical experiments. The majority of our results are new for multivariate random fields indexed over other domains, too. We express some of them for the case of the sphere.
2010 Mathematics Subject Classification. Primary 60G60; Secondary 62G05, 43A75, 42B35.
Characteristics and whole-genome analysis of a novel Pseudomonas syringae pv. tomato bacteriophage D6 isolated from a karst cave
Authors: Wu Qingshan , An Ni , Fang Zheng , Li Shixia , Xiang Lan , Liu Qiuping , Tan Leitao , Weng Qingbei
Published: March 2023

Pseudomonas syringae is a gram-negative plant pathogen that generally infects plants such as tomato and threatens global crop production. In this study, a novel lytic phage (named Pseudomonas phage D6) infecting P. syringae pv. tomato DC3000 was isolated from the karst cave sediments and characterized. The latent period of phage D6 was shown to be 60 min, and the burst size was 16 plaque forming units/cell. Phage D6 was stable at 30 − 40°C and lost infectivity after heated to 70°C. The infectivity of phage D6 was unaffected at pH 6 − 10, but was inactivated at pH ≤ 5 or ≥ 12. The genome of phage D6 is a linear double-stranded DNA of 307,402 bp with a G + C content of 48.43%. It showed low similarity to known phage genomes in the GenBank database and Viral sequence database. Genomic and phylogenetic analyses revealed that phage D6 is a newly discovered phage. A total of 410 open reading frames (ORFs) and 14 tRNAs were predicted in the genome, 92 of which encode for proteins with predicted functions. In conclusion, the lytic phage D6 identified in this study belongs to a novel phage of the class Caudoviricetes, and has potential application in biological control of plant diseases.
Assessment of Morphometric Characteristics of Gojeb watershed, Omo-Gibe Basin, Ethiopia
Authors: Mekuria Eyasu Tafese
Published: March 2023

In this work, morphological features and basin characteristics of the Gojeb watershed, Omo-Gibe Basin, were identified and analyzed using GIS and image processing techniques. Watershed delineation and analysis of morphological features based on Shuttle Radar Topography Mission (SRTM) DEM data were performed using GIS hydrology tools. This study also assesses the sub-basins' morphometric metrics, such as area, perimeter, stream frequency, maximum width and length, drainage density, and stream orders, as well as their geometric characteristics. The results led to delineate nine sub-watershed with nine stream orders, the drainage density of these sub-basins are ringing between 0.75 to 0.99 km/km2. Stream orders were calculated, The outcomes allowed for the delineation of nine sub-watersheds with nine stream orders, having a drainage density of between 0.75 and 0.99 km2/km2. There are 1763 streams with a length of 941.26 km as the first order, 503 streams with a length of 307.09 km as the second order, 3755 streams with a total length of 1128.46 km as the third order, 1144 streams with a total length of 696.56 km as the fourth-order streams, and 519 streams with a total length of 425.86 km as the fifth order, 1284 streams with a length of 796.66 km as the sixth, 615 with a total length 429.69 km as seventh order, 873 with a total length 529.72 km as eighth-order streams, and 985 with a total length 708.38 km as ninth order. The stream length is greatest in the third order, and it gets shorter as the stream order gets higher. This finding may be helpful to regional planners and national decision-makers for agricultural and water management policies.
“We Can Tell Them, But Not Right Now!” - Hiv Status Disclosure and Related Factors Among Children Aged 6-14 Years Living with Hiv in Kilimanjaro Region, Tanzania
Authors: Msoka Perry Cyril , Mtesha Benson A. , Masika Lyidia , Maro Rehema , Swai Iraseni , Emmanuel Naomi , Ngowi Kennedy , Boer Marion Sumari-de
Published: March 2023

Background: In Tanzania, disclosure of HIV status to children remains a challenge despite the World Health Organization (WHO) recommendation that children should be informed about their HIV status between the ages of 6 to 12 years. This study aims to determine HIV status disclosure and related factors among children living with HIV in Kilimanjaro, Tanzania.
Method: A cross-sectional study using a convergent parallel mixed-methods design was conducted from September 2021 to February 2022 among children aged 6-14 years receiving HIV care. Semi-structured questionnaires were collected from caregivers of undisclosed children, including socio-demographic data and reasons for non-disclosure. Additionally, we interviewed 20 caregivers of children in-depth who had disclosed and not disclosed the status to their children; we also interviewed children whose HIV status had been disclosed, followed by a focus group discussion. Bivariate and multivariate logistic regression analyses identified factors associated with HIV status disclosure. P<0.05 was considered statistically significant. We did thematic content analysis for qualitative data.
Results: 121 children and their parents or caregivers were included in the analysis and 51(42%) knew about their HIV status. 31%(n=38) of children were between the ages 6-8 and among them, 33(87%) did not know about their status. Thirty-nine percent (n=47) of children were between the ages of 9-11; 32(68%) did not know about their status. 30% (n=36) of the children were above 12 years old, and 5(14%) did not know their status. 60 children were girls (49.5%); the majority (n=75;62%) lived with their biological parents; 112 children had primary education (93%); and 94 (78%) children attended referral hospitals for ART services. Moreover, 86(71%) of the children had caregivers who had been interviewed. In the final multivariate model, children aged above 12 years (OR= 30; 95%; Cl= 7.2-124); children aged 9-11(OR=2.7;95%; CI= 0.8-9.0) and having a treatment supporter (OR=2.9; 95%CI=1.0-8.2) were significantly associated with HIV status disclosure to their children compared to their counterparts respectively. Through IDI, we revealed the following themes: (1) HIV disclosure challenges and reasons not to disclose the status, (2) the process of the disclosure, and (3) the Importance of disclosure.
Conclusion: HIV status disclosure to children living with HIV in Kilimanjaro region was associated with age above 12 years and having a treatment supporter, unlike the WHO recommendation. Therefore, health facilities should introduce new strategies to ensure children know their HIV status.
Optimal Profile for a Fin of Constant Cross Section With Modelation of the Thermophysical Properties
Authors: Camaraza-Medina yanan , hernandez-Guerrero abel , Luviano-Ortiz Jose L
Published: March 2023

The dependence of the temperature and composition on thermal conductivity of steel, and its influence in the optimal profile for a fin of constant cross section to be used in air cooled condenser is presented. In Air Cooled Condensers (ACC), air is used as refrigerant, which forces the need for fins to improve the heat transfer process leading to appreciable increments in the costs of the installation. Therefore, developing better fins profile will allow optimizing the operation, maximizing the heat transfer and minimizing the manufacturing cost of the fins. To this objective, in the present paper, three geometric parameters, thickness, height and surface of heat transfer of the fin, this parameters influence directly the optimal obtained profile for conditions of maximum heat flux and optimal Biot number. The study was accomplished for fins of constant cross section. In a future work, fins of variable cross sections will be considered.
Associations of “Life’s Essential 8” cardiovascular health with dementia risk, cognition, and neuroimaging markers of brain health
Authors: Zhou Rui , Wu Xian-Bo
Published: March 2023

Importance:The American Heart Association (AHA)’s Life’s Essential 8 (LE8) score, a recently updated metric for promoting cardiovascular health (CVH), has addressed the limitations of the original metrics (Life’s Simple 7) and is able to quantify CVH.
Objective:To evaluate the associations of LE8 score with the risk of incident dementia and its subtypes, cognition, and neuroimaging outcomes and to determine whether these associations differ among apolipoprotein E (APOE)-ε4 genotypes.
Design, Setting, and Participants:UK Biobank participants without prior cardiovascular disease nor dementia at baseline (2006–2010) were enrolled in this prospective cohort study. Data analysis was conducted from December 20, 2022, to February 15, 2023.
Exposures:A modified version of the LE8 score was created (range: 0–100) and categorized into poor (0–49), intermediate (50–79), and optimal (80–100) CVH.
Main Outcomes and Measures:The outcomes included incident dementia (all-cause, vascular [VaD], and Alzheimer’s disease ascertained through hospital inpatient and death records), cognitive test scores (fluid intelligence and numeric memory), and neuroimaging markers (total brain volume [BV], white matter hyperintensity [WMH], and hippocampal volume). Adjusted Cox proportional hazard and multivariable linear regression models were used.
Results: A subsample of 316,669 participants (mean [SD] age, 56.3 [8.1] years) were included. Higher LE8 scores were associated with reduced risk of all-cause dementia and VaD, the adjusted hazard ratios (HRs) in the optimal CVH versus the poor CVH group were 0.56 (95% confidence interval [CI], 0.48–0.64) and 0.29 (95% CI, 0.22–0.38), respectively. A 10-point increment in LE8 was associated with higher fluid intelligence (β, 0.088; 95% CI, 0.073–0.102) and numeric memory (β, 0.054; 95% CI, 0.043–0.065), and was also associated with lower WMH volume (β, −0.673; 95% CI, from −0.751 to −0.596) and larger BV (β, 77.93; 95% CI, 62.03–93.84) and hippocampal volume (β, 0.197; 95% CI, 0.106–0.288). These associations were more evident in APOE-ε4 noncarriers.
Conclusions and Relevance: Individuals with a higher LE8 score experienced less dementia events (driven especially by incident VaD) and were associated with better neurocognitive brain health profiles. CVH optimization may be beneficial to the maintenance of brain health.
How hospitals response to disasters; a conceptual deep reinforcement learning approach
Authors: Mirbakhsh Ardeshir
Published: March 2023

During a disaster the requests for using ambulance services increases. Efficient assignment of the ambulances leads to lowering the patients' travel time. Simulating these environments is very complex and needs a solid framework. This paper uses a Deep Reinforcement Learning approach to better schedule ambulance dispatch problem during those disasters. The concept of a call and assignment of ambulances are illustrated and the elements of states, rewards, and actions in the formulations are described. The algorithm steps for solving this problem are also presented. This paper can help disaster planners to have a better idea for better scheduling ambulances.
Kommunikation, Konsens und Kohäsion im universitären Kontext
Authors: Stadler-Altmann Ulrike , Winkler Gerda , Moser Eva-Elisabeth
Published: March 2023

Gesellschaftlicher Zusammenhalt wird in Bildungseinrichtungen (Eckert 2007) als Teil eines individuellen, aber gesellschaftlich verantworteten Sozialisationsprozesses in den entsprechenden Lebensphasen (Abels et al. 2008) erfahren. Dafür sind Kommunikationsprozesse von Bedeutung, die entweder selbst zu einem Konsens führen oder in denen die Entstehung eines Konsenses nachvollzogen werden kann. In den kommunikativen Aushandlungsprozessen während eines Studiums werden Wissensbestände diskutiert und Wissensstrukturen aufgebaut. Studierende, aber auch Lehrende erleben so einen Lehr-Lernzusammenhang, der bestenfalls die Genese wissenschaftlichen Wissens verdeutlicht, und erkennen, dass gesättigtes wissenschaftliches Wissen vom Konsens der Beteiligten abhängig ist. Konsens führt damit zu einem geteilten Wissensbestand, der über den konkreten Lehrkontext hinaus Geltung hat und zu sozialer Kohäsion innerhalb der Universitätsgemeinschaft, darüber hinaus in der Scientific Community und in der Gesellschaft an sich führen kann. Dieser fragile Zusammenhang zwischen Kommunikation, Konsens und Kohäsion in der Wissenschaft ist abhängig von verfügbarem Wissen und damit von der Informationsbeschaffung. Veränderungen, wie sie während der Pandemie zu beobachten waren, als Bibliotheksbestände nurmehr digital zugänglich waren und alle Lehr- und Forschungsanstrengungen in die digitale Welt verlegt wurden (Breitenbach 2021), wirken sich deshalb direkt und indirekt auf die Kommunikation der Universitätsgemeinschaft (Mayrberger 2020; Morselli et al. 2021) aus. Deshalb muss die Frage gestellt werden, wie sich das wissenschaftliche, gesellschaftlich geteilte Wissen verändert und welche Auswirkung es haben kann, wenn nurmehr digitale Bestände und Medien genutzt werden können.
Bedingungen zur Ermöglichung von Bildung und Teilhabe junger Geflüchteter im Kontext digitalisierter Bildungsarrangements
Authors: Friedrichs-Liesenkötter Henrike , Hüttmann Jana
Published: March 2023

Der vorliegende Artikel befasst sich mit dem Zusammenspiel von digitalen Medien, Bildung und Teilhabe mit einer Fokussierung auf das Thema Flucht. Das durch das BMBF geförderte ethnografische Forschungsvorhaben Bildungsteilhabe Geflüchteter in digitalisierten Bildungsarrangements (BIGEDIB) (Laufzeit 2019-2022) widmet sich in praxistheoretischer Perspektive der Frage nach (Bildungs-)Teilhabe in unterschiedlichen medial durchdrungenen Bildungs- und Alltagskontexten junger Geflüchteter mittels Feldprotokolle teilnehmender Beobachtungen. Der Artikel zeigt anhand beispielhafter Sequenzanalysen zentrale Forschungserkenntnisse im Hinblick auf Bedingungen für die Ermöglichung von (Bildungs-) Teilhabe im Kontext digitalisierter Bildungsarrangements. Ein zentrales Analyseergebnis ist die Notwendigkeit der Herstellung von Passung zwischen fachlich-personalen Anforderungen, subjektiven Voraussetzungen junger Geflüchteter und Charakteristika digitaler Artefakte unter der Rahmung der institutionellen Bedingungen im Bildungsarrangement.
Mit Journalismuskompetenz den gesellschaftlichen Zusammenhalt stärken
Authors: Beiler Markus , Krüger Uwe , Menner Sophie , Pfeiffer Juliane
Published: March 2023

Etwa ein Drittel der Deutschen hegt Misstrauen gegenüber den etablierten Medien und glaubt, dass Journalist:innen in Zusammenarbeit mit der Politik die Bevölkerung belügen und manipulieren. Mangelndes Wissen über Strukturen und Arbeitsweisen des Journalismus ist eine der Ursachen, die zu solchen Vorstellungen führen können. Um dem zu begegnen, wird in diesem Beitrag mit «Journalismuskompetenz» ein neues Modell und Konzept für die Lehramtsausbildung vorgestellt, das enger als «Medienkompetenz», aber breiter als «Nachrichtenkompetenz» gefasst ist. Es lehnt sich an das Modell der «Demokratiekompetenz» nach Audigier an und umfasst eine kognitive, eine affektive und eine sozial-praktische Dimension. Die kognitive Dimension wird mithilfe des «Zwiebelmodells» des Journalismus nach Weischenberg operationalisiert und erstmals empirisch in einer Befragung von Lehramtsstudierenden der Universität Leipzig (n = 585) erhoben. Die Befragung ergab ein durchschnittliches Journalismus-Wissen auf dem Niveau der Schulnote Vier; es wurden positive Korrelationen des Wissens u. a. mit dem Medienvertrauen, dem Politikvertrauen, dem Alter und dem vorherigen Belegen eines universitären Seminars über Journalismus festgestellt. Es erscheint daher plausibel, dass mit verstärkten Bildungsanstrengungen – wie sie aktuell in der Lehramtsausbildung der Universität Leipzig getätigt werden – die Journalismuskompetenz und mittelbar auch das Medienvertrauen erhöht werden kann.
SPECIFICS AND TRENDS OF COVERAGE OF RELIGIOUS CONFLICTS IN
THE MEDIA ENVIRONMENT
Authors: Opanasenko Yulia
Published: March 2023

Introduction. In times of great upheaval, people feel an urgent need to see a measured and balanced picture of events. It soothes, gives a sense of control over one’s life. In Ukrainian society, there is an increased interest in the topic of religion, because two-thirds of citizens consider themselves believers. Considering such a high percentage of believers in Ukraine, representatives of the mass media sector cannot and should not avoid the topic of religion, especially when it comes to conflict situations.
Relevance of the study. Since the war waged by Russia against Ukraine also has a pronounced religious aspect, it is relevant to investigate how the approach of domestic regional media to covering the specified topic changed before and during the large-scale war.
Methodology. The research used such methods as content analysis, the comparison method, the systematic approach, and the generalization method. To achieve the results, the content of the publications of the Sumy, Kharkiv, Luhansk and Donetsk regions, namely the Internet resources “Panorama”, “Slobidskyi kray”, “Pervaya polosa” and “62.ua” were analyzed. Monitoring was carried out from 01.01.2022 to 06.30.2022.
Results. Analysis of the content of online publications of the North-Eastern region revealed that on the eve of a full-scale war, materials on religious topics were mostly informative and entertaining in nature. During a full-scale war, the choice of genres shifted exclusively to news. Journalists did not use new formats that would interest young people, either before or during the war. During the large-scale invasion of Russia in Ukraine, the degree of tension in publications on the specified topic increased significantly. Hate speech, emotionalism and irrevocability appeared in the materials. The tonality of the headlines and quotes of the headlines and quotes in the news speaks of the aggravation of the religious conflict between representatives of the Ukrainian Orthodox Church and the Orthodox Church of Ukraine. There are cases when journalists use unverified information, which is a direct violation of journalistic standards. There is a noticeable tendency to ignore important religious topics.
Conclusions. A promising direction for further research can be a comparative analysis of coverage of religious topics in other regions of Ukraine. It will help to form a general picture of its presentation before and during the full-scale war in Ukraine. Based on the results of these studies, it is possible to formulate basic recommendations for journalists.
Optimalisasi Penjualan melalui Digital Marketing
Authors:   Universitas Pamulang, Jl. Surya Kencana No. 1, Pamulang Barat, Kecamatan Pamulang, Kota Tangerang Selatan, Banten, Indonesia, Nurhayarti Nurhayarti , Sugiyarti Listya ,   Universitas Pamulang, Jl. Surya Kencana No. 1, Pamulang Barat, Kecamatan Pamulang, Kota Tangerang Selatan, Banten, Indonesia, Hanah Siti ,   Universitas Pamulang, Jl. Surya Kencana No. 1, Pamulang Barat, Kecamatan Pamulang, Kota Tangerang Selatan, Banten, Indonesia, Asmilia Nur ,   Universitas Pamulang, Jl. Surya Kencana No. 1, Pamulang Barat, Kecamatan Pamulang, Kota Tangerang Selatan, Banten, Indonesia, Sutandijo Sutandijo ,   Universitas Pamulang, Jl. Surya Kencana No. 1, Pamulang Barat, Kecamatan Pamulang, Kota Tangerang Selatan, Banten, Indonesia
Published: March 2023

Partners in this PKM program are culinary MSME actors who are members of the Pamulang Estat MSME Community who must survive during the Covid 19 Pandemic. Pempek Mama Dea Pamulang MSMEs and Bundes are members of the Pamulang Estat MSME Community as WUB (New Entrepreneurs) who need to get coaching from several parties including from the academic field to be able to become a better MSME. The purpose of this Community Service activity is to provide insight, training, and assistance such as optimizing the use of digital marketing in product marketing. The urgent problem currently being faced by partners is the lack of awareness and knowledge/insight into the use of digital marketing to support increasing income and surviving the COVID-19 pandemic. Thus, in order to optimize sales through digital marketing, MSME actors need assistance. This Community Service activity uses mentoring and training methods with a service learning approach through material presentations, hands-on practice, and tutorials by the Community Service team face-to-face with strict procedures during the Covid-19 pandemic. Feedback from service activities by filling out questionnaires from participants. The result of the service activity is to market the products of MSME actors by optimizing digital marketing so that income increases. This activity provides benefits for participants, namely MSME actors in obtaining maximum knowledge/insight on product sales activities and can improve income.
Manajemen Sumber Daya Insani dalam Pengelolaan Heritage Pesantren
Authors:   Program Studi Ekonomi Syariah, Fakultas Keislaman, Universitas Trunojoyo Madura Jl. Raya Telang, PO. Box 2 Kamal 69162, Bangkalan, Madura, Jawa Timur, Indonesia, Nur Afifah Isnaini , Noor Hasan Dony Burhan ,   Program Studi Ekonomi Syariah, Fakultas Keislaman, Universitas Trunojoyo Madura Jl. Raya Telang, PO. Box 2 Kamal 69162, Bangkalan, Madura, Jawa Timur, Indonesia
Published: March 2023

The purpose of this study describes the management of pesantren cultural heritage by pesantren human resources which includes planning, recruitment, and evaluation of human resource development in pesantren. This research uses a qualitative descriptive approach. The location of this study is in Pesantren Annuqayah Guluk-Guluk Sumenep. Data collection techniques using interview methods, documentation and observation. Informants in this study included pesantren caretakers and regional and central pesantren caretakers. The form of data in this study is primary data and secondary data obtained from informants and supporting documents. Analysis of data through descriptive analysis. The results showed that the cultural heritage of pesantren Annuqayah in the form of (1) manuscripts of books written by the caretakers of pesantren, Jami' Mosque, and grave the founder of pesantren Annuqayah; (2) the management of human resources in the management of pesantren heritage includes analysis of human resource development, recruitment process, education and training programs, formation of pesantren culture, as well as evaluations that are emphasized on changes in attitudes and behaviors in carrying out duties and responsibilities.
Inovasi Teknologi Pemasaran Terintegrasi bagi Pembudidaya Ikan Hias
Authors:   Institut Teknologi dan Bisnis Ahmad Dahlan Jakarta, Jl. Ir H. Juanda No.77, Cireundeu, Kec. Ciputat Tim., Kota Tangerang Selatan, Banten 15419, Indonesia, Siswanto Tito , Gusneli Gusneli ,   Institut Teknologi dan Bisnis Ahmad Dahlan Jakarta, Jl. Ir H. Juanda No.77, Cireundeu, Kec. Ciputat Tim., Kota Tangerang Selatan, Banten 15419, Indonesia, Mardika Isnan Hari ,   Institut Teknologi dan Bisnis Ahmad Dahlan Jakarta, Jl. Ir H. Juanda No.77, Cireundeu, Kec. Ciputat Tim., Kota Tangerang Selatan, Banten 15419, Indonesia
Published: March 2023

The main problems faced by partners in general are marketing problems; It is still limited and conventional and there is no integrated marketing between decorative fish cultivators. A solution to the main problem is the application of integrated marketing technology using joint marketing methods for decorative fish cultivators in Parigi Mekar Village, Ciseeng District. In particular, this program has the objective of increasing market reach for decorative fish cultivators through website media, and increasing sales effectiveness by creating decorative fish sales centers. The activity approach method is through a participatory approach. This approach emphasizes efforts to improve human quality in order to increase real participation in activities. Devotion provides value to farmers and creates a positive image of the partner's location as the largest ornamental fish producer in West Java through the Ornamental Fish Village brand. In addition, by implementing the program effectively and sustainably, the program can motivate cultivators to develop their cultivation results. Other support in the form of website-based digital marketing can also reach a wider market network which has an impact on creating connectedness between cultivators and outsiders.
Edukasi Penggunaan Aplikasi Akuntansi UKM
Authors:   Politeknik Keuangan Negara STAN, Sektor V, Jl. Bintaro Utama 5, Jurang Manggu Timur, Kecamatan Pondok Aren, Kota Tangerang Selatan, Banten 15222, Indonesia, Trisulo Trisulo , Berliana Lawi Kresensia ,   Politeknik Keuangan Negara STAN, Sektor V, Jl. Bintaro Utama 5, Jurang Manggu Timur, Kecamatan Pondok Aren, Kota Tangerang Selatan, Banten 15222, Indonesia, Sianturi Indra Polma ,   Politeknik Keuangan Negara STAN, Sektor V, Jl. Bintaro Utama 5, Jurang Manggu Timur, Kecamatan Pondok Aren, Kota Tangerang Selatan, Banten 15222, Indonesia, Napitupulu Danny Haryanto ,   Politeknik Keuangan Negara STAN, Sektor V, Jl. Bintaro Utama 5, Jurang Manggu Timur, Kecamatan Pondok Aren, Kota Tangerang Selatan, Banten 15222, Indonesia
Published: March 2023

Micro, Small, and Medium Enterprises (MSMEs) are trading businesses or economic activities carried out by individuals or groups of people who have a role in Indonesia's economic development. The existence of MSMEs which have a major role in the economy needs to be maintained and developed so that they can provide more benefits for the community and the Indonesian economy. The problem for MSMEs today is the lack of ability and knowledge in the field of accounting, especially in recording and making financial reports. The PKN STAN Community Service Program is integrated with the Student Work Lecture (KKM) conducted by the Ak 106 group to help MSME actors to have the ability to manage their finances. The activity focused on providing technical guidance related to the use of SME Accounting applications to partners who own Halal Mart SMEs in Duri City, Bengkalis Regency, Riau. The method used in educating the use of SME Applications is the training and visiting system (LAKU) method, intending to help partners record and prepare financial reports. As a result of these activities, MSME Halal Mart partners can use the Android-based SME Accounting application and realize the benefits and ease of recording accounting using the application.
Purification capacity of natural biofilms and their physiochemical and biological properties: a case study in the Jishan River, a heavily polluted river
Authors: Wang Dan , Zhu Xianbin , Xi Wenxiang , Pan Hongzhong , Yao Huaming , Du Yueling
Published: March 2023

Natural biofilms, which are widely distributed in various aquatic environments, can not only serve as bioindicators of various anthropogenic contaminants but also participate in the purification and degradation of various pollutants. However, the inherent purification capacity of natural biofilms and their physiochemical and biological properties are still poorly understood. In this study, outdoor sampling and indoor experiments were used to explore the purification abilities of natural biofilms. The physiochemical and biological properties of natural biofilms were further investigated to reveal their purification mechanism. The results demonstrated that natural biofilms had an excellent purification effect on heavily polluted water. Indoor experiments showed that the purification capacity of natural biofilms was dominated by microbial biodegradation rather than physical biosorption, and after 14.0 days of incubation, the removal rates of COD, TP, NH4+-N, and NO3--N could reach 93.6, 80.83, 85.93, and 81.03%, respectively. The SEM, FTIR spectra, and component analyses revealed that natural biofilms were mainly composed of polysaccharides and proteins. The dominant phyla in the bacterial community structure were Campilobacterota, Proteobacteria, Bacteroidota, Firmicutes, and Desulfobacterota, and the major phyla in the fungal community structure were Chytridiomycota and Ascomycota. These microorganisms might be the main degraders of riverine pollutants.
Huellas de san Agustín en Kant
Authors: Narváez Arango Javier
Published: March 2023

El libro se desarrolla en tres partes. En la primera encontramos el tiempo, el espacio, el fenómeno, el númeno, las categorías, los juicios sintéticos a priori, el mundo, el alma y Dios, expuestos por Kant en la Crítica de la razón pura. En la segunda parte encontramos los mismos temas desde san Agustín, haciendo un paralelo, para mostrar las semejanzas entre estos autores, encontrando, entre otras cosas, que san Agustín, al igual que Kant, menciona el fenómeno como lo que se me aparece, así como la semejanza conceptual de las categorías en Kant y las nociones puras del entendimiento en san Agustín. También mostramos cómo en ambos autores las ideas de mundo, alma y Dios son tomadas para integrar todo el conocimiento, con la diferencia de que en Kant son supuestos necesarios que no se pueden experimentar, pero que se deben suponer, mientras que en san Agustín estos son etapas del conocimiento para alcanzar el único conocimiento verdadero. Concluye la obra hablando de Platón como el eslabón que une a estos dos pensadores.
Correlations between Quantum Calculations and the Contribution of Factors
Affecting the Structural Stability and Electronic Properties of Vinyl
Azide and Vinyl Isocyanate
Authors: Fallah Hengameh , Atabaki Hooshang , Moharrery Leila , Hasanzadeh Neda , Yahyaei Hooriye
Published: March 2023

The conformational features of vinyl isocyanate (1) and vinyl azide (2) have been analyzed
using G4MP2, CCSD(T)/6-311+G**, B3LYP/6-311+G** and LC-ωPBE/6-311+G** theory levels.
Published experimental data indicate that the stability of the cis-isomer of vinyl azide (2) is more than
the trans-isomer. This is consistent with the findings attained using G4MP2 and LC-ωPBE/6-
311+G** levels, whereas B3LYP/6-311+G** and CCSD (T)/6-311+G** levels provide false energetic
outcomes. Natural Bond Orbital (NBO) interpretation is used to interpret the reason for the stability
of the cis stereoisomer of compound 2 and the structural features of compound 1. Dipole-dipole interactions,
steric effects, and resonance energies on the structural behaviors of compounds 1 and 2 are
also investigated using NBO analysis. The results showed that the stability of the cis conformer of
compound 2 compared to its trans conformer could be explained using the steric effect (Pauli Exchange
Type Repulsion or PETR). Dipole moments of the cis conformer of compound 2 are evaluated
experimentally (from Rotational Spectroscopy) and theoretically. The experimental (from Rotational
Spectroscopy) and theoretically evaluated dipole moments of trans-conformation of compound 2 are
slightly greater than that in cis-conformation, which is in favor of the cis-conformation, while dipoledipole
interactions are in favor of the cis-conformation of compound 1. Accordingly, the electrostatic
interactions associated with dipole-dipole interactions do not explain the conformational behaviors of
compound 1. The stabilization energies related to the delocalization of electrons are in favor of the
cis-conformation of compound 1, whereas it has no considerable effect on compound 2’s conformational
behavior.
Diabetes Type II: Should Aspartame be a Concern?
Authors: Choudhary Arbind Kumar
Published: March 2023

Blood sugar levels have to be controlled by individuals with type II diabetes
(T2D) to preserve health and longevity. For such people, artificial sweeteners
(including aspartame) are proposed sugar substitutes. In particular, the protection of
aspartame has long been the point of discussion. Although it is such a problematic
product, T2D patients are advised by many physicians to use it during a managed diet
and as part of a treatment modality. Aspartame is 200 times sweeter than sugar and has
a marginal effect on blood glucose levels. It is recommended for use so that T2D can
regulate carbohydrate consumption and blood sugar levels. Previous studies, however,
indicate that aspartame consumption may increase a person's risk of gaining weight
instead of losing weight, resulting in intolerance to blood glucose in T2D. By
increasing the levels of cortisol, aspartame can act as a biochemical stressor. It may
cause systemic oxidative stress by creating excess free radicals, altering the gut's
microbial activity, and interacting with the receptor N-methyl D-aspartate (NMDA),
resulting in insulin deficiency or tolerance. Due to the lack of reliable evidence,
aspartame and its derivatives are safe for T2D yet are still debatable. In the already
stressful physiology of T2D, more research is needed to provide indications and raise
concerns that aspartame may worsen the prevalence of pathological physiology.
Diabesity and the Kidney
Authors: Elrggal Mohamed E. , Elkeraie Ahmed , Carriazo Sol , Sawaf Hany , Khor Si Yuan , Elkeraie Yasmine , Haddad Issa , Moustafa Khaled , Hassanein Mohamed
Published: March 2023

Diabetes Mellitus and obesity, now coined as “Diabesity”, is a worldwide
epidemic that imposes a huge burden on healthcare and society. Diabesity has been
associated with poor outcomes and increased morbidity and mortality. The kidneys are
a vulnerable target of diabesity. In this chapter, we discuss the epidemiology,
pathophysiology, and treatment of diabesity–induced kidney disease. We specifically
focus on the therapeutic targets and pharmacological management of diabesity-related
kidney diseases.