bluuebunny/crossref_metadata_2025 huggingface dataset:
La ciudad, disgregación y fragmentación por los proyectos inmobiliarios; el caso de Azcapotzalco, Ciudad de México
Authors:   , Caballero Martínez Juan Carlos
Published: May 2022

La investigación propuesta tuvo como finalidad conocer cómo ha sido el diseño y planificación de la vivienda en los conjuntos de departamentos erigidos en el periodo 2013-2018. Para ello se analizaron dos zonas en Azcapotzalco, Ciudad de México, en donde se han erigido proyectos de vivienda en conjuntos de departamentos, uno en el Pueblo originario de Santa Catarina Atzacualco y el otro en la Colonia Ampliación del Gas. Se indagó sobre cuál fue el origen urbano de estos proyectos de vivienda, la idea arquitectónica-urbanística que hay detrás y cuál ha sido el impacto urbano de estos proyectos en la ciudad. La aportación que trae esta investigación es entender que la vivienda es inherente a la ciudad misma. Asimismo, comprender que el diseño de la vivienda no está únicamente en la estructura física de la misma, sino en su relación con el entorno circundante. La investigación tendrá como eje importante la vivienda y su relación con la ciudad.
A structured literature review on construction conflict prevention and resolution: A modified approach for engineering
Authors: Sabri Omar , Lædre Ola , Bruland Amund
Published: May 2022

In the face of several uncertainties in the construction industry, conflicts and disputes seem inevitable. The aim of this systematic literature review of methodologies for prevention and resolution of conflicts was to develop an updated guidance for conflict management in the construction industry. To achieve this, we developed a novel tool termed Modified Reporting Items for Structured Reviews in Engineering and Technology (MORISE) that considered a modified tool from the original literature review method Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Three databases, ScienceDirect, Scopus, and American Society for Civil Engineers (ASCE), were searched and 61 articles were shortlisted. In terms of frequency of reasons cited as causes for disputes, payment regimes and delays rank first, followed by written agreement interpretation and changes in projects. Acceptable approaches to resolution of disputes include negotiation, arbitration, facilitation, and dispute resolution boards. This study were able to make a clear distinction between methodologies adopted by various researchers for the prevention and resolution of conflicts and show that in addition to prevention of conflicts, there are comprehensive and suitable techniques to resolve conflicts, which can be adopted in practice.
Perencanaan Lanskap Sempadan Sungai sebagai Kawasan Rekreasi di Hilir Tukad Yeh Empas, Kabupaten Tabanan
Authors: Putra Aditya Pratama , Asmiwyati I Gusti Agung Ayu Rai , Gunadi I Gusti Alit
Published: May 2022

Landscape planning of river border a recreation area in the lower Tukad Yeh Empas, Tabanan Regency. Tukad Yeh Empas is one of the streams in Tabanan Regency that is typically used for irrigation and recreation purposes by the surrounding community, toughTukad Yeh Empas still requires a landscape plan as it shows a detioration tendency of its environment such as water pollution, improper land use change and riverbank erosion.  The purpose of this study is to create a recreation landscape plan of Tukad Yeh Empas.  The method used for this research was surveying using techniques of data collection through the use observation, interviews, questionnaires, and literature study. The stages of this research were preparation, data inventory, data analysis, synthesis, concept development and landscape planning. The data analysis and synthesis carried out information that evaluated the constraints and potencies of the biophysical and socio-cultural conditions and also suggested alternative plans. With the use of spatial analysis and its technique of ranking and scoring the data was applied to alocate recreation zones with the help of Geographycal Information System (GIS). There were three recreational zones: a less potential recreation zone, quite potential recreation zone, and great potential recreational zone. Vegetation that had functions for conservation, cultivation and aesthetics was recommended for this landscape planning. The concept of circulation and facilities was developed according to the user's needs for an attractive recreation without dangering the landscape.
ANALIZA RADA SBR POSTROJENJA PROMENOM VREMENA REAKCIJE
Authors: Milić Marijana
Published: May 2022

Zadatak rada obuhvata proračun i dimenzionisanje postrojenja za biološko prečišćavanje otpadnih voda aktivnim muljem primenom SBR sistema za slučaj kontinualnog i diskontinualnog dotoka vode. Cilj je prikazati koliko je vremenski parametar trajanja celokupnog ciklusa, a i pojedinačnih faza, značajan za proces prečišćavanja u pogledu opterećenja, dimenzija reaktora i predrezervoara, kapaciteta pumpi i dekantera, potrebne količine kiseonika, mase mulja koju je potrebno ukloniti i ostalih radnih parametara.
KONTROLA KVALITETA OTISAKA TABAČNE OFSET ŠTAMPE DOBIJENIH GRAFIČKIM SISTEMOM KBA Rapida 106
Authors: Horak Sanja , Kašiković Nemanja , Milošević Rastko
Published: May 2022

Standardizacija odštampanih otisaka je važan faktor u grafičkoj proizvodnji jer od nje zavisi u velikoj meri kvalitet odštampanog otiska. Uz pomoć analize i mernih instrumenata možemo doći do zaključka koje promene u većoj meri ugrožavaju proces štampe. U datom radu ispitivanja su rađena na podlogama GALERIE ART GLOSS gramature 150 g/m² i VANTAGE GLOSS gramature 250 g/m². Na papiru ove gramature štampana su tri različita posla, sličnog tiraža i različitog vremenskog perioda štampe.

Upoređivanjem rezultata merenja optičke gustine, preklapanja boje, sivog balansa, CIE L*a*b*, spektralne refleksije i beline i žutoće papira, moguće je videti kako kvalitet u toku štampe, na grafičkom sistemu KBA Rapida 160/8 odstupa od prvobitnih vrednosti.
KONTROLA OŠTRINE FOTOGRAFIJA DOBIJENIH POMOĆU PREDNJIH KAMERA MOBILNIH TELEFONA
Authors: Jokić Jovan , Jurič Ivana
Published: May 2022

Pronalaženje i analiziranje sličnosti i razlika između prednjih kamera pet različitih mobilnih telefona. Prezicnije, upoređivanje i kontrola oštrine fotografija dobijenih mobilnim telefonima čiji modeli će biti naznačeni u tekstu. Koristeći se specijalnim grafikonima za testiranje i Imatest softverom, može se doći do kvantitativnih rezultata koji nam pružaju informacije vezane za kvalitet oštrine.
ГИМНАСТИЧКИ ЦЕНТАР У НИШУ
Authors: Чарапић Невена
Published: May 2022

Рад се бави реконструкцијом и доградњом постојећег објекта. Спроведено истра­живање имало је за циљ да дође до оптималног функ­ционалног и обликовног решења објекта за промоцију спорта и психо-физички развој младих, поштујући принципе одрживости. Резултат истраживања представљен је пројектом Гимнастичког центра у Нишу.
MULTIFUNKCIONALNI OBJEKAT U NOVOM SADU
Authors: Simić Danica
Published: May 2022

Rad se sastoji iz tekstualnog dela teorijske analize i grafičkih priloga. U tekstu su obrađene sve teme vezane za koncept projektovanog objekta, stručna analiza karakterističnih detalja i SWOT analiza multifunkcionalnog objekta u Novom Sadu. Teme na kojima je rad zasnovan, jesu samoodrživost, ekologija i savremena arhitektura.
GENERISANJE PLANA PROSTORIJA PODDEOBOM PRAVOUGAONIKA
Authors: Radovanović Nemanja
Published: May 2022

Tema ovog rada jeste ispitivanje rada algoritma generisanja rasporeda prostorija na tipologiji jednoporodične kuće pravougaonog oblika.
EКСПРОПРИЈАЦИЈА ЗА ПОТРЕБЕ ИЗГРАДЊЕ ПРИСТУПНОГ ПУТА И ПОСТРОЈЕЊА ЗА ПРОСЕЈАВАЊЕ ПЕСКА У ЋИЋЕВЦУ
Authors: Jović Ana , Таталовић Јелена
Published: May 2022

Предмет истраживања овог мастер рада је реализација пројекта експропријације за потребе изградње приступног пута и постројења за просејавање песка у општини Ћићевац. Представљени су сви геодетски радови за потребу реализације горепоменутог пројекта, као и подаци о експроприсаним парцелама.
Tinjauan Kelengkapan Pengisian Sertifikat Penyebab Kematian Di Rumah Sakit : Literature Review
Authors: Fitriani Fitriani , Rachmawati Ervina , Nuraini Novita , Muflihatin Indah
Published: May 2022

The death cause's certificate is used to document the major cause of the death and to identify the mortality circumstance that used to inform about the health policy and to enhance the strategy of the death prevention and recording. The purpose of this study is to investigate the percentage of completeness towards the filling of the cause of death certificate and to know the factor causing the incompleteness towards the filling of the death cause's certificate. This type of study is the literature review with 11 selected journals according to the inclusion criteria. There are four components in the analysis of the completeness towards the filling of the death cause's certificate namely, patient identification, important report, author authentication, and good recording. In the result of the study, the lowest percentage component was found in the important report at 55.96% and the highest percentage component was found in the author's authentication at 93.72%. The most dominant factor in the incompleteness towards the filling of the death cause's certificate is due to the absence of SOP and the excessive number of components in the death cause's certificate. The suggestion for future researchers is they might redesign the death cause’s certificate by attaching the sections or columns as needed.
EVALUASI KEBERHASILAN IMPLEMENTASI SIMRS DI RUMAH SAKIT X KABUPATEN JEMBER DENGAN PENDEKATAN METODE TTF
Authors: Suhartatik Suhartatik , Putra Doni Setiawan Hendyca , Farlinda Sustin , Wicaksono Andri Permana
Published: May 2022

Rumah Sakit X di Kabupaten Jember menerapkan Sistem Informasi Manajemen Rumah Sakit (SIMRS) semenjak tahun 2012. Hasil studi pendahuluan yang dilakukan peneliti menunjukkan bahwa masih terdapat beberapa permasalahan dalam penerapan SIMRS. Diantaranya adalah ketidaksesuaian data dan ketidaklengkapan fitur yang berdampak pada penggunaan dan dampak kinerja. Tujuan dari penelitian ini adalah untuk melakukan evaluasi keberhasilan implementasi SIMRS di Rumah Sakit X Kabupaten Jember menggunakan Task Technology Fit (TTF). Jenis penelitian ini adalah penelitian kuantitatif dengan teknik pengumpulan data melalui kuesioner yang melibatkan 54 responden. Hasil penelitian menunjukan bahwa identifikasi variabel TTF di Rumah Sakit X Kabupaten Jember menunjukkan Task Characteristic (TAC) memiliki jumlah skor 80,1 %, Technology Characteristic (TEC) memiliki jumlah skor 77,5 %, Task Technology Fit (TTF) memiliki jumlah skor 78,17 %, Performance Impact (PI) memiliki jumlah skor 78,19 %, dan Utilization (U) memiliki jumlah skor 80,25 %. Saran yang diusulkan oleh peneliti terkait masalah diatas adalah Rumah sakit perlu melakukan perbaikan dan pengembangan terhadap sistem terkait kekonsistenan data, kelengkapan fitur, dan pengoptimalan fitur dalam SIMRS sesuai dengan kebutuhan pengguna sehingga meningkatkan keberhasilan implementasinya.
Faktor Penyebab Keterlambatan Waktu Pengembalian Berkas Rekam Medis Pasien Rawat Inap
Authors: Wardhina Faizah , Rahmadiliyani Nina
Published: May 2022

The activity of returning medical record files for inpatients at Mawar Hospital has a standard return time of 1 x 24 hours after the patient returns. Medical records that experience delays in returning will have an impact on the delay in data processing, delays in submitting insurance claims, and delays in service to patients. The purpose of this research was to determine the factors causing the delay in returning inpatient medical record files at Mawar Hospital. The research method used is qualitative. The research subjects were the head nurse of the inpatient room and the head of the medical record, also called the main informant. In this study, the validity of the data was also carried out by triangulation to other informants, an inpatient nurse. The conclusions of this study are the factors that cause delays in returning the medical record files of inpatients at Mawar Hospital: man factor are doctors or nurses, the material factor is an incomplete filling of medical record files, the method factor is incomplete standard operating procedures, the money factor is no budget for granting rewards for doctors or nurses in carrying out their duties.
Pengembangan Sistem Monitoring Suhu dan Kelembaban di Ruang Fermentasi Tembakau Bawah Naungan (TBN) Berbasis Internet of Things (IoT)
Authors: Rusdianto Andrew Setiawan , Khasanah Lia Milata , Suryadharma Bertung , Wibowo Yuli , Mahardika Nidya Shara
Published: May 2022

Fermentation is one of the processes in tobacco processing which will be used as raw material for cigars. One of the main aspects that must be considered to achieve successful fermentation is the temperature and humidity of the fermentation room, namely 60-80% RH and 27-32 °C. KOPA Tarutama Nusantara (TTN) Jember is a Under Shade Tobacco processing unit with manual monitoring of temperature and humidity using a hygrometer which causes workers to experience fatigue and delays in taking action if the temperature and humidity are not up to standard. Based on these problems, an IoT (Internet of Things)-based temperature and humidity monitoring tool is needed. The research was carried out by assembling tools using Arduino Ide, DHT 11 Sensor, 2 Channel Relay, LM2596 and programmed with Arduino Ide software. Based on the functionality validation test, this tool can be said to function properly because the X value is 1. The efficiency value is declared very efficient with a value 6.9% and the effectiveness value is declared very effective because the effectiveness value increases from 17 to 22. The implementation of this tools in the fermentation room also increases the effectiveness of tobacco quality with a value of 112.9%.
Evaluasi Selang Waktu Pengukuran Ozon Dalam Proses Pengolahan AMDK Di PT. Tirta Sukses Perkasa Jember
Authors: Fauziah Ega Nur’aini , Ramadhan Prasetya , Yudiastuti Silvia Oktavia Nur
Published: May 2022

The main use of water is as drinking water. PT. Tirta Sukses Perkasa is a company that produces Bottled Drinking Water (AMDK) with the trademark Club and Viand. A critical control point in the production of bottled drinking water is disinfection with ozone technology. Ozone monitoring at PT. Tirta Sukses Perkasa is held every 2 hours. To increase the effectiveness of production, a study was conducted to determine the effect of time interval monitoring ozone on the production process of bottled drinking water. The evaluation was carried out with an interval of 1 hour and 4 hours of monitoring. The interval of 1 hour and 4 hours was done to find out the efficient time for one work shift. One work shift is 8 working hours so in 1 hour the monitoring of ozone concentration is carried out 8 times/shift. The interval of 1 hour and 4 hours is done to find out the efficient time for 1 shift.The data processing method used is the t test. Based on the results of the evaluation of the tests carried out, it is known that the ozone in 1, 2, and 4 hours time intervals is not significantly different.
Diseño y optimización de una mezcla de compota, elaborada a partir de pulpa de guayaba, chalarina y oca
Authors: Terrones Lizbeth A. , Terrones Jorge E. , Idrogo Luis A. , Castillo Luis G. , Velásquez-Barreto Frank F.
Published: May 2022

Este estudio tuvo como objetivo diseñar y optimizar una mezcla de compota, elaborada a partir de pulpa de guayaba, chalarina y oca. Para ello, se utilizaron frutas de guayaba, chalarina y tubérculos de oca recién cosechados, a los que se extrajeron las pulpas sin presencia de cáscara, pepas y materias extrañas. Seguidamente, las pulpas fueron escaldadas a 90 °C por 5 min y fueron mezcladas en proporciones de 0-100 %, de acuerdo al Diseño de Mezclas Simplex Centroide.  La optimización se realizó teniendo en cuenta las variables de respuesta aceptabilidad y diferencial de color (ΔE). Las mezclas elaboradas con altos porcentajes de pulpa de guayaba y chalarina y bajos porcentajes de pulpa de oca mostraron una mayor aceptabilidad. La mezcla con un 66,66 % de pulpa de guayaba, 16,66 % de pulpa de chalarina y 16,66% de pulpa de oca presentó la mayor aceptabilidad de los panelistas. Las mezclas con altos porcentaje de pulpa de guayaba y chalarina y con proporciones iguales de las pulpas de guayaba, chalarina y oca (33,33 %/ 33,33 %/ 33,33 %) presentaron altos valores de ΔE. Los modelos cuadráticos para la aceptabilidad y ΔE exhibieron un mejor ajuste de los datos (R2 ajustado > 0,70), en comparación con los modelos lineales. La mezcla de pulpas óptimas fue la elaborada con 75 % de pulpa de guayaba y 25 % de pulpa de oca. Esto indica que las mezclas elaboradas con pulpa de guayaba y oca fueron las más aceptadas por los panelistas y presentaron el mayor ΔE.
Diseño de un sistema de inocuidad alimentaria para exportar pasta de ají rocoto a Estados Unidos, según la norma ISO 22000:2005
Authors: Velarde Andrea
Published: May 2022

La presente investigación se realizó en las instalaciones de la empresa Kuri Néctar SAC, de la provincia de Lambayeque, región Lambayeque y su objetivo fue diseñar un sistema de inocuidad alimentaria que permita reducir los niveles de peligros potenciales en la elaboración y comercialización a los Estados Unidos de la pasta de ají rocoto. Se empleó un diseño en la estructura de la documentación para implementar la seguridad de los documentos y registros. Se valoró el diagnóstico por especificación según evaluación y cumplimiento por cada sección de la norma ISO22000:2005 en la empresa, se estableció el lineamiento de redacción de los documentos, así como los programas de prerrequisitos operativos, el Plan HACCP y el Sistema de Trazabilidad.
CONCEPTUAL PRINCIPLES OF THE ESSENCE SUBSTANTIATION OF CREDIT MARKET
Authors:   Yuriy Fedkovych Chernivtsi National University, Zhavoronok Artur
Published: May 2022

The article examines the conceptual provisions for substantiating the essence of the category "credit market". To this end, an analysis of the current state of research and study of the approaches to understanding the credit market formed in the scientific literature was conducted. Also, taking into account the results of the analysis of the content of the definition of "credit market", the author's approach to its consideration was substantiated and the relevance of the study was confirmed by bibliographic analysis of research in this category. The study was based on Scopus platform data search functions using the VOSviewerprogram. In particular, emphasis is placed on the importance of understanding the essence of the credit market through the prism of the study of the number of publications and their citations, which indicates the relevance of this topic.The main task of the study is to study the essence of the definition of "credit market", to determine the author's approach to understanding the content of this economic category and bibliographic analysis.The study led to the conclusion that the number of publications that directly study the nature and features of the credit market through the prism of its essence, is constantly growing. In our opinion, further research should determine the essence of the credit market as a separate category, a description of its features and factors of formation. It is determined that an important condition for the functioning of the credit market is the existence of a system of regulation of relations in the credit market.The scientific novelty of this work is the further development of the concept and role of the credit market in ensuring the effective development of the national economy based on the analysis of research results of domestic and foreign scholars, which Scopus platform.
THE CONCEPT, ESSENCE AND ROLE OF REGULATORY POLICY INECONOMY DEVELOPMENT
Authors:   ZaporizhzhiaNational University, Krylov Denys , Chub Anton ,   Academician Yuriy BugayInternational Scientific and Technical University
Published: May 2022

The article proves that the main controllers of the effectiveness of regulatory policy are independent analitical centres, business associations and other non-governmental organizations. As reasons for the low quality of legal support, it is noted the complete secrecy of public authorities from citizens during the submission, discussion and decision-making.The main task of the study is to analyze the experience gained and generalize the existing conceptual framework to determine the nature and role of regulatory policy in the development of a market economy.It was found that from the point of view of system analysis and methodology of functional modeling, the control system of the object of public administration is called the regulator and provides its adaptive properties through feedback. Since public administration organizations cannot physically regulate the activities of all business entities without exception in the manual mode, the regulatory framework at the macro level is the regulatory field. This determines the rules of the market, the rights and obligations of all parties, as well as the relationship between them. At the same time, in the frameworkof the implementation of state regulatory policy, the existing regulatory framework is in itself an object of management. The regulator, in this case, are state bodies endowed with these functions, in accordance with the Law of Ukraine.The work provides a complex dynamic system with several levels of government: the first level of government, directly represents the state regulatory activity, where the object is the regulatory field, and the regulator -government agencies; the second level of management provides socio-economic development in the desired direction, where the object is the national economy or its individual sectors, small businesses, etc. Accordingly, the regulator is represented by the existing regulatory framework. The future formalization of this approach in the definition of regulatory policy will establish a causal relationship between public administration and economic development and ensure the effectiveness of such activities. The scientific novelty of this work is the further development of the concept and role of regulatory policy in ensuring the effective development of the economic system based on the analysis of research results of domestic scientists, which in contrast to existing tools state regulatory activity and strategic development of the country.
Doing Literature Now
Authors: Nethersole Reingard
Published: May 2022

Opinion Piece
Treating the Hips For Low Back Pain May be Effective: For the Right Patient
Authors: McLaughlin Kevin H. , McGee Terrence
Published: May 2022

Letter to the Editor-in-Chief in response to JOSPT article “When Treating Coexisting Low Back Pain and Hip Impairments, Focus on the Back: Adding Specific Hip Treatment Does Not Yield Additional Benefits—A Randomized Controlled Trial” by Burns et al. J Orthop Sports Phys Ther 2022;52(5):300. doi:10.2519/jospt.2022.0202
“My Pain Is Unbearable…I Cannot Recognize Myself!” Emotions, Cognitions, and Behaviors of People Living With Musculoskeletal Disorders: An Umbrella Review
Authors: Martinez-Calderon Javier , Matias-Soto Javier , Luque-Suarez Alejandro
Published: May 2022

Objective

To summarize (1) the emotions, cognitions, and behaviors of people who are living with musculoskeletal disorders related to symptoms and (2) the interactions of emotions, cognitions, and behaviors with the person's environment (family, social, and work roles).

Design

An umbrella review of qualitative research syntheses and meta-summaries (metasynthesis, meta-ethnographies, meta-aggregation, meta-summary).

Literature Search

We searched CINAHL, EMBASE, PsycARTICLES, PsycEXTRA, PsycINFO, PubMed, and PubPsych from database inception to January 2021. We also searched gray literature via Open Grey and Google Scholar.

Study Selection Criteria

We included qualitative evidence syntheses evaluating adults with musculoskeletal disorders, based on the multidimensional diagnostic criteria for acute and chronic pain. Emotions, cognitions, and behaviors were the phenomenon of interest.

Data Synthesis

We developed 3 categories of themes ([1] emotions, [2] cognitions, and [3] behaviors) for each objective. We selected the 3 most common emotions, cognitions, and behaviors that appear as themes in our narrative synthesis.

Results

We included 20 qualitative evidence syntheses that retrieved 284 original qualitative studies. Despair, distress, and fear were the main emotions reported by people living with musculoskeletal disorders. The alterations of the self and how people described their symptoms, what caused them, and how the symptoms impacted their lives were the most common cognitions. Cognitive strategies (ie, acceptance) and perceptions about social support emerged. People often used passive behaviors (eg, social isolation or hiding symptoms) to cope with the challenges that arose related to musculoskeletal symptoms. However, some people actively faced their symptoms, planning their activities or practicing them despite their symptoms.

Conclusion

Clinicians who support people living with musculoskeletal disorders should consider (1) assessing other emotions than pain-related fear (eg, despair and distress), (2) observing their cognitive responses (ie, acceptance), and (3) evaluating what type of behaviors people use (eg, active or passive). J Orthop Sports Phys Ther 2022;52(5):243–261. doi:10.2519/jospt.2022.10707
Application of Indicators for Assessing Environmental Aspects of Chemical Processes to Case Studies From Pharmaceutical Production
Authors: Fischer Ulrich , Hungerbühler Konrad
Published: May 2022

As a result of legislation and increasing public awareness, environmental considerations are given more and more importance in chemical process design. Furthermore, the focus in environmental protection has shifted from end-of-pipe technologies to improvements of the chemical processes.
The realization of such improvements, on one hand, requires chemical or technical innovations (new molecules, new synthesis routes, new process designs) and, on the other hand, assessment methods are needed that deliver an objective comparison of process alternatives on appropriately defined
system boundaries.Four different indicators for assessing the environmental impact of chemical processes are discussed: Mass Loss Indices (MLI), Environmental Indices (EI), a comprehensive EHS (Environment, Health, and Safety) assessment method, and Eco-Indicator 95, an evaluation method
used in the Life Cycle Analysis (LCA) framework. These methods are summarized, compared, and applied to case studies from the chemical industry. Finally, the corresponding results are discussed and conclusions on the capability and limitations of the different indicators are drawn, in particular
with regard to their applicability during the early phases of process development.
A Catalytic Green Process for the Production of Niacin
Authors: Chuck Roderick
Published: May 2022

A brief overview is provided of the commonly known methods for producing nicotinic acid (niacin), together with a comment on the fulfilment of the requirements for a green process. This is preceded by a short discussion on what is here understood as 'green', together with the importance of niacin. Lonza's contribution to Green Chemistry is illustrated by a new process for producing niacin, namely the direct air oxidation of picoline.
Secret Messages and Ciphers: The Phenomenon of Crypto Quotation in Musical Art
Authors: Денисов А.В.
Published: May 2022

В статье рассматривается специфическая разновидность цитаты, смысл которой по воле автора доступен для понимания ограниченному числу слушателей, конкретному адресату или же только ему самому. Таким образом, расшифровка этого смысла возможна лишь благодаря изучению писем, дневников, комментариев в черновиках сочинений, а в ряде случаев и вовсе не допускает адекватной трактовки. Известны случаи, когда подобные цитаты уничтожались в более поздних редакциях опуса, так как автор опасался, что они будут слишком узнаваемы (И. Брамс). Показаны причины обращения композиторов к криптоцитатам, в их числе — следование цензурным запретам (Р. Шуман), стремление воплотить личные воспоминания и переживания (Л. Бетховен), представление в произведении автобиографических ситуаций (Р. Шуман), склонность автора к максимальной неповторимости своего стиля и, соответственно, недопустимость для него явных цитат (Э. Элгар). В любом случае, криптоцитата усложняет структуру художественного текста и, как правило, способствует усилению многозначности его интерпретации. Эти свойства отчасти позволяют объяснить особое значение феномена криптоцитаты в музыкальном искусстве XIX–XX веков.

The paper examines a specific kind of quotation, the meaning of which, by the author's will, is accessible to a limited number of listeners, to a specific addressee, or only to himself. Thus, the decoding of this meaning is possible only based on letters, diaries, comments in drafts of works, and in some cases does not allow an adequate interpretation at all. There are cases when such quotes were destroyed in later versions of the opus, since the author was afraid that they would be too recognizable (J. Brahms). The reasons for the composers to appeal to crypto-quotes include censorship (R. Schumann), desire to embody personal memories and experiences (L. Beethoven), presentation of autobiographical situations in the work (R. Schumann), the author's penchant for maximum uniqueness of style and, accordingly, the inadmissibility of explicit quotes (E. Elgar). In any case, cryptoquotes complicate the structure of the artistic text and, as a rule, increases ambiguity of its interpretation. These properties partly explain special significance of the crypto quotation phenomenon in the musical art of the XIX–XX centuries.
The Saint Petersburg Conservatory in 1866–1868 (Based on the Report of the Russian Musical Society)
Authors: Сартакова Е.С. , Куликова Е.Е.
Published: May 2022

В статье впервые публикуются архивные материалы, относящиеся к начальному периоду становления Санкт-Петербургской консерватории. Отчет Русского музыкального общества за 1866–1868 годы содержит информацию по всем направлениям деятельности консерватории: разработка учебных и экзаменационных программ, принятие решений по вопросам организации концертов, по ведению документации, управлению штатом преподавателей и другие вопросы. Значение данного документа заключается в том, что он позволяет осмыслить изменения, благодаря которым консерватория вышла на новый уровень своего развития. В нем приводятся сведения о педагогическом составе, проведении Совета и общего Собрания профессоров, организации процедуры итоговых экзаменов, выпускниках. Таким образом, публикация данных материалов о разных аспектах деятельности консерватории представляет очевидную ценность для исследования истории отечественного музыкального образования в целом.

The article presents previously unknown archival materials relating to the early stage of development of the St. Petersburg Conservatory. The report of the Russian Musical Society of 1866–1868 contains information on all areas of the conservatory's activities: elaboration of the curriculum and exam programs, concert, documentation, staff management and othes. The significance of this document is explained by the fact that it allows us to comprehend the changes that brought the conservatory to a new level of development. It provides information about the faculty, meetings of the Council and the General Meeting of the professors, the final exams procedure, and the graduates. Therefore, publication of these materials on various aspects of the conservatory’s activities is of obvious value for studying the history of Russian music education in general.
Songs of the Pinezhsky Region in the Recordings of Fyodor Alexandrovich Abramov
Authors: Иванова Татьяна Григорьевна
Published: May 2022

Рецензия на книги: Материнское наследство. Фольклор Пинежского края, записанный Федором Абрамовым от Степаниды Павловны Абрамовой в 1939 году / Изд. подгот. Е. И. Якубовская. - Архангельск: Лит.-изд. центр «Лоция», 2019. - 87 с.; Культурное наследие Пинежья. Фольклор Пинежского края, записанный Федором Абрамовым в 1939 году / Изд. подгот. Е. И. Якубовская. - Архангельск: Лит.-изд. центр «Лоция», 2020. - 263 с.

Review of: Maternal Inheritance: Folklore of the Pinezhsky Region, Recorded by Fyodor Abramov from Stepanida Pavlovna Abramova in 1939. Prepared by E. I. Yakubovskaya. Arkhangelsk: Lit.-publishing center “Lotsia”, 2019. 87 p.; The Cultural Heritage of Pinezhye: Folklore of the Pinezhsky Region, Recorded by Fyodor Abramov in 1939. Prepared by E. I. Yakubovskaya. Arkhangelsk: Lit.-publishing center “Lotsia”, 2020. 263 p.
Effect of lipophilicity in oxyanions responsive Eu(III) complexes
Authors: Grenier Laura , Nielsen Lea G , Sørensen Thomas Just
Published: May 2022

Responsive lanthanide(III) complexes—europium(III) complexes in particular—has been the focus of studies for several decades. The response, in the form of changes of photophysical and electronic properties of the lanthanide(III) ion, arises through supramolecular interactions between a guest or analyte molecule, and the lanthanide(III) complex which acts as host. While responsive lanthanide complexes have been reported and investigated frequently, the supramolecular aspects and linear free-energy relationship have had less attention. Here, we are revising five europium(III) complexes and investigating their binding to nine different guests, all with a primary interaction between europium(III) ion and a bidentate carboxylate anion. The media effect was investigated, and by eliminating the impact of hydrophobic effects, we can show that selectivity in these host-guest systems can be tuned by the secondary lipophilic interactions.
When it is too much: Identifying butamben excess on the surface of pharmaceutical preformulation samples by Raman mapping
Authors: Mitsutake Hery , Rodrigues da Silva Gustavo Henrique , de Paula Eneida , Breitkreitz Márcia Cristina
Published: May 2022

In nanostructured lipid carriers (NLC), the type and amount of excipients will determine API solubility and therefore the maximum drug load. Butamben is a topical local anesthetic which formulation in lipid-based DDS is difficult due to its affinity for hydrophilic solvents, which might not miscible with the solid lipid. This indicates that a medium polarity excipient might be needed. The first step of this study comprised a throughout screening study to evaluate API solubilization in different excipients. Then excipients with low (Dhaykol® 6040 LW) and high (Capryol® 90) solubilization capacities were selected for microscopic evaluation by Raman mapping. For Capryol® 90 a mixture design of experiments was carried out to study the proportions of excipients, using as responses the DHI (distributional homogeneity index) and standard deviation of the histograms. Clusters of the API were observed I the samples prepared with Dhaykol®, confirming the low solubilization capacity. In this case, DHI was an adequate parameter to indicate solubilization/miscibility. In the case of Capryol®90 samples, no clusters were observed due to its higher solubilization capacity, however since it was homogeneously distributed throughout the analyzed surface, the DHI values were low, indicating the need for a 3D image.
Laser-assisted surface activation for the fabrication of flexible non-enzymatic Cu-based sensors
Authors: Khairullina Evgeniia , Ratautas Karolis , Panov Maxim , Andriianov Vladimir , Mickus Sarunas , Manshina Alina , Račiukaitis Gediminas , Tumkin Ilya
Published: May 2022

We developed a rapid and effective technique for fabrication of sensor-active copper-based materials on the surface of such flexible polymers as terephthalate, polyethylene naphthalate and polyimide using the method of laser surface modification. For this purpose, we optimized the polymer surface activation parameters using laser sources with a picosecond pulse duration for subsequent selective metallization within the activated region. Further, the fabricated copper structures were modified with gold nanostructures and by electrochemical passivation to produce copper-gold and oxide-containing copper species, respectively. As a result, in comparison with pure copper electrodes, these composite materials exhibit much better electrocatalytic performance concerning the non-enzymatic identification of biologically important disease markers as glucose, hydrogen peroxide and dopamine.
Equipping data-driven experiment planning for Self-driving Laboratories with semantic memory: case studies of transfer learning in chemical reaction optimization
Authors: Hickman Riley , Ruža Jurgis , Roch Loïc , Tribukait Hermann , García-Durán Alberto
Published: May 2022

Optimization strategies based on machine learning (ML), such as Bayesian optimization, show promise across the experimental sciences as a superior alternative to traditional design of experiment. Deploying ML optimization tools in R\&D operations increases productivity and efficiency, while reducing the time and cost necessary to identify new molecules, materials, and process parameters with desired target properties. Additional benefits can be captured when combining these ML algorithms with automated laboratory equipment with Atinary’s orchestration software platform SDLabs. The synergy of these technologies are referred to as Self-driving Laboratories, which hold the potential to revolutionize scientific experimentation, data collection, and materials discovery. Thus far, however, autonomous experimentation projects have not fully leveraged pre-existing knowledge and databases, often beginning from scratch and sequentially collecting measurements from new experiments. This is in stark contrast to experimentation by humans, where trained experts rely on intuition acquired from experience to select initial parameter settings for a novel experiment. In this work, we introduce Atinary’s transfer learning algorithm SeMOptt, a general-purpose Bayesian optimization framework which uses meta-/few-shot learning to efficiently transfer knowledge from related historical experiments and databases to a novel experimental campaign via a compound acquisition function. We apply SeMOpt to chemical reaction optimization, an important and challenging task in chemistry. Specifically, we perform two case studies: i) the optimization of five simulated cross-coupling reactions, which demonstrates the ability of our approach to adapt to data with unknown effects, such as the presence of a side reaction, catalyst deactivation, and measurement noise; ii) the optimization of palladium-catalyzed Buchwald-Hartwig cross-coupling of aryl halides with 4-methylaniline in the presence of potentially inhibitory additives. We find that SeMOpt accelerates the optimization rate by a factor of 10 or more compared to standard single-task ML optimizers (those without transfer learning capabilities to leverage historical experiments or databases). Moreover, these case studies show that \semopt outperforms several existing ML Bayesian optimization strategies that leverage historical data. Thus, we believe this work presents a valuable technical contribution for general-purpose optimization and makes the case to replace the traditional trial-and-error experimentation process with Self-driving Labs augmented with semantic memory.
An In Silico Explainable Multi-Parameter Optimization Approach for De Novo Drug Design Against Proteins from Central Nervous System
Authors: Bung Navneet , Krishnan Sowmya Ramaswamy , Roy Arijit
Published: May 2022

The aim of drug design and development is to produce a drug which can inhibit the target protein and possess a balanced physicochemical and toxicity profile. Traditionally, this is a multi-step process where different parameters such as activity, physicochemical and pharmacokinetic properties are optimized sequentially, which often leads to high attrition rate during later stages of drug design and development. We have developed a deep learning-based de novo drug design method which can design novel small molecules by optimizing target specificity as well as multiple parameters (including late-stage parameters) in a single step. All possible combinations of parameters were optimized to understand the effect of each parameter over the other parameters. An explainable predictive model was used to identify the molecular fragments responsible for the property being optimized. The proposed method was applied against the human 5-hydroxy tryptamine receptor 1B (5-HT1B), a protein from the central nervous system (CNS). Various physicochemical properties specific to CNS drugs were considered along with the target specificity and blood-brain barrier permeability (BBBP), which acts as an additional challenge for CNS drug delivery. The contribution of each parameter towards molecule design was identified by analyzing the properties of generated small molecules from optimization of all possible parameter combinations. The final optimized generative model was able to design similar inhibitors compared to known inhibitors of 5-HT1B. In addition, the functional groups of the generated small molecules that guide the BBBP predictive model were identified through feature attribution techniques.
Exploration of NaSICON Frameworks as Calcium-ion Battery Electrodes
Authors: Tekliye Dereje Bekele , Kumar Ankit , Weihang Xie , Mercy Thelakkattu Devassy , Canepa Pieremanuele , Sai Gautam Gopalakrishnan
Published: May 2022

The development of energy storage technologies that are alternative to the state-of-the-art lithium-ion batteries but exhibit similar energy densities, lower cost and better safety, is an important step in ensuring a sustainable energy future. Electrochemical systems based on Calcium (Ca)-intercalation form such an alternative energy storage technology, but require the development of intercalation electrode materials that exhibit reversible Ca-exchange with reasonable energy density and power density performance. To address this issue, we use first-principles calculations, screening over the wide chemical space of sodium superionic conductor (NaSICON) frameworks, with a chemical formula of CaxM2(ZO4)3 (where M = Ti, V, Cr, Mn, Fe, Co, or Ni, and Z = Si, P, or S) for Ca electrode materials. We calculate the average Ca2+ intercalation voltage, and the thermodynamic stability (at 0 K) of charged and discharged Ca-NaSICON compositions. We find CaxMn2(PO4)3 and CaxV2(PO4)3 NaSICONs to be promising as Ca-cathodes given their energy densities and thermodynamic (meta)stabilities, while CaxMn2(SO4)3 and CaxFe2(SO4)3 NaSICONs can also be explored as Ca-intercalation hosts. Additionally, we find all silicate Ca-NaSICONs to be thermodynamically unstable and hence unsuitable as Ca-cathodes. We report the overall trends in Ca-intercalation voltages, thermodynamic stabilities, and the ground state Ca-vacancy configurations in all the NaSICON compositions considered. Our work contributes to unearth strategies for developing practical calcium-ion batteries, involving polyanionic intercalation frameworks.
Visualization of Electron Density Changes Along Chemical Reaction Pathways
Authors: Lander Chance , Satalkar Vardhan , Yang Junjie , Pan Xiaoliang , Pei Zheng , Chatterji Aayushi , Liu Chungen , Nicholas Kenneth , Cichewicz Robert , Yang Zhibo , Shao Yihan
Published: May 2022

We propose a simple procedure for visualizing the electron density changes (EDC) during a chemical reaction, which is based on a mapping of rectangular grid points for a stationary structure into (distorted) positions around atoms of another stationary structure. Specifically, during a small step along the minimum energy pathway (MEP), the displacement of each grid point is obtained as a linear combination of the motion of all atoms, with the contribution from each atom scaled by the corresponding Hirshfeld weight. For several reactions (identity SN2, Claisen rearrangement, Diels-Alder reaction, [3+2] cycloaddition, and phenylethyl mercaptan attack on pericosine A), our EDC plots showed an expected reduction of electron densities around severed bonds (or those with the bond-order lowered), with the opposite observed for newly-formed or enhanced chemical bonds. The EDC plots were also shown for copper triflate catalyzed N2O fragmentation, where the N–O bond weakening initially occurred on a singlet surface, but continued on a triplet surface after reaching the minimum-energy crossing point (MECP) between the two potential energy surfaces.
Assessment оf the state оf compensatory resources and the dеgrее оf adaptation оf the body tо environmental conditions in full-term infants: cross-sectional study
Authors: Derevtsov Vitaly V. , Neudakhin Evgeniy V. , Antonova Liudmila K. , Romanyuk Fedor P. , Ivanov Dmitry O. , Kozlova Lyudmila V. , Вekezin Vladimir V. , Chumakova Galina N. , Chistyakova Guzel N. , Shcherbakova Marina Yu. , Derevtsova Anastasia V.
Published: May 2022

Aim. Assessment of the state of compensatory resources and the degree of adaptation of the body to environmental conditions in early and full-term infants in comparison with each other and with practically healthy children.
Materials and methods. Under the supervision of 135 infants. 110 were born from mothers with a burdened somatic and obstetric-gynecological history, 41 of them were born at 3738 weeks (Group 1), 69 at 3942 weeks (Group 2). The control group (Group 3) consisted of 25 practically healthy children born to practically healthy mothers as a result of physiological pregnancies and childbirth at 3840 weeks. The children were examined in dynamics at the age of 1 (n=126), 3 (n=116), 6 (n=110), 12 (n=111) months. A comprehensive analysis of the data of anamnesis, physical examination, cardiointervalography was carried out. The following parameters were evaluated initially and in response to the tilt test: mode (М0), mode amplitude (AM0), delta x (∆Х), voltage index (IN). Nonparametric methods of statistical analysis were used.
Results. At the age of 2 to 3 days infants born to women with a history of poor health recorded a significant decrease in the median IN1 value, respectively, in Groups 1, 2, and 3, which indicates a decrease in compensatory reserves, particularly in neonates born at 3840 weeks. At 1 month of age, Group 1 and 2 had higher median IN1 values of 804 and 746 versus 550 in Group 3, indicating the development of compensatory resource tension, particularly in children born at 3738 weeks. At 3 months of age, children in group 1 retained a compensatory tension of IN1 resources 521 versus 468 and 460 in groups 2 and 3. At 6 months of age, there is a slight decrease in compensatory IN1 reservers at 6 months of age in children from women with a history of a history of a history of a history of a disease 376 and 357 versus 400 in Group 3. At 12 months of age, children in the main groups have even more decreased compensatory resources, especially in group 1 IN1 206, 284 and 380 respectively in groups 1, 2 and 3.
Conclusion. The decrease of functional reserve of adaptation in children of groups 1st and 2nd was facilitated by the influence burdened with somatic and obstetric-gynecological history of mothers, regardless of gestational age and subsequently the health characteristics of children themselves. The statistically significant differences found in the state of compensatory resources and the degree of adaptation of the organism to environmental conditions justify the personalized approach, which justifies a personalized approach when choosing rehabilitation measures.