bluuebunny/crossref_metadata_2025 huggingface dataset:
Database “Librarianship and Bibliography” as a Resource for Information Support of Studies in Library Science
Authors: Sukhotina Milena L.
Published: October 2018

The article considers the bibliographic database “Librarianship and Bibliography”, developed by the specialists of the Russian State Library in the context of other libraries and institutions that distribute resources related to library science. The author reveals the specifics of structure and composition of databases with similar resources, created by some central regional libraries of Russia and federal libraries of other departments. The authar touches upon the issue of foreign companies’ information support of studies in library science. This database was created using many years, experience in formation of information resources on culture and art, which have no analogues in Russia. The article presents the search capabilities of this bibliographic online resource and the practice of user interaction with it in 2016—2017. The author notes that the main body of records includes articles from monographs, scientific collections, conference proceedings and other publications. The article outlines the features of working with the database. The resource interface and the structure of its search fields are described. There are given some examples of its search fragments and navigation capabilities. Using statistical data, the author analyses the resorce access dynamics, user requests and the geography of user access to the database. The access leaders among the eight regions of the Russian Federation are Ural, Northwestern and Siberian Federal Districts. There is a stable interest observed in Siberian, Volga and Central Districts. The rating of the most popular search terms is made. The results of the study confirm the demand for the online resource among users. This is especially important in the conditions of low circulation of Russian scientific publications that significantly decreases their accessibility and reduces the ability to disseminate scientific knowledge among specialists.
State Public Scientific and Technological Library of the Siberian Branch of the Russian Academy of Sciences: the First Centenary
Authors: Posadskov Aleksander L. , Lavrik Olga L.
Published: October 2018

The article describes the history of the State Public Scientific and Technological Library of the Siberian Branch of the Russian Academy of Sciences (SPSTL SB RAS) — firstly the State Scientific Library (SSL), established in 1918 in Moscow and transformed into SPSTL SB RAS in 1958. The authors present the stages of its development and main achievements. The library developed its collections, publishing and educational activities, created the network of its branches practically in all industrial regions of the country. During the Great Patriotic war, the Library based its work on the priority satisfaction of the defence information needs. Despite the loss of holdings on the occupied territory, it developed the network of branches, setting the task of bibliographic service for the defence industry.

In 1946, given general scientific importance of the Library, it was transferred to the USSR Ministry of Higher Education. The new status of the Library has forced to expand significantly its acquisition to technical literature, publications on natural science, social science and humanities. In 1958, the Library was transferred to Novosibirsk. Its main task became information support of scientific research; it developed its forms and methods, generated its own resources and actively engaged in the automation and informatization of library and information processes. Here the Library began to develop library science, bibliography, book science and applied informatics. In fact, the communication between the user and the library, the librarian and the information resource moves exclusively into the electronic environment. Over 60 years of activity in Siberia, the Library has become a unique scientific and cultural Siberian phenomenon, combining the features of the universal public library, the centre for scientific and technical information and the unified centre for automation of library and information processes of the Siberian Branch of the Russian Academy of Sciences.
Studi Kelayakan Pekerjaan Pemilihan Zona Produksi dan Squeeze off Cementing pada Sumur MY05
Authors: Novrianti Novrianti
Published: October 2018

Meningkatnya water cut pada sumur MY05 menyebabkan terjadinya penurunan produksi minyak. Untuk mengatasi masalah tersebut, perlu dilakukan pekerjaan squeeze off pada zona perforasi yang mempunyai kontribusi produksi minyak yang rendah dan potensi produksi air yang tinggi. Setelah pekerjaan squeeze off selesai, selanjut dapat dilakukan pekerjaan shot top perforation (STP) untuk membuka zona produksi supaya produksi minyak dapat produksi. Pemilihan lapisan sand 1440’ sebagai target perkerjaan squeeze off dan STP berdasarkan jumlah cadangan minyak yang tersisa (remaining oil reserve). Selain itu studi keekonomian juga dilakukan untuk mengetahui  tingkat kelayakan proyek. Hasil kedua pekerjaan tersebut mengindikasikan adanya peningkatan produksi minyak sebesar 405 BOPD dan berkurang nya nilai water cut menjadi 76%. Hasil analisa keekonomian menunjukkan bahwa pekerjaan tersebut sangat ekonomis untuk dilakukan.
The Enhancing Cement Strength through Utilization of Rice Husk Ash (RHA) Additive: An Experimental Study
Authors: Rita Novia , Novrianti Novrianti , Novriansyah Adi , Ariyon Muhammad
Published: October 2018

Designing a slurry with adequate strength resistance is a major objective in oil and gas completion job. Various studies and research confirms that Compressive Strength (CS) and Shear Bond Strength (SBS) are two parameter which is imperative in describing cement strength in well cementing job. This experimental study introduces a Rice Husk Ash (RHA), an alternative cement additive derived from organic waste. RHA rich in silicon oxide (SiO2) and has a pozzolanic reaction, which is correlated in enhancing cement strength. Serial cement samples with various concentration of RHA were prepared to investigate the effect of RHA concentration to CS and SBS. All samples were then Dried for 24 hours in room condition after completing mixing and molding process. A Biaxial Loading test was then performed to all samples to determine the CS and SBS values by using hydraulic press apparatus. Results from the loading test generally indicate an enhancement of CS and SBS for samples with 31%, 32%, 33%, and 34% RHA. An indication of higher CS and SBS is not found for sample with 35% RHA, comparing with 34% RHA. Thus, 34% RHA is the optimum concentration for theses study, which yield 1312. psi of CS and 158.16 psi of SBS.  Through this study, there is an opportunity for transforming waste material into alternative additive with higher economic value.
ANALYSIS OF DAMAGE ROD STRING COMPONENTS IN SUCKER ROD PUMP IN THE FIELD SS
Authors: Fitrianti Fitrianti , Haryono Anwar
Published: October 2018

Field SS is a Heavy Oil field which means high viscosity oil making it difficult to flow. Therefore, artificial lift was used in this field to help lifting the high viscosity fluid, i.e. sucker rod pump (SRP). In the last several years, problem of the damage to the rod string was frequently occur. Rod string damage is usually indicated by the occurrence of broken or detached components. In order to overcome the damage of rod string components on the sucker rod pump, several parameters that causes rod string damage in 41 well samples in the field SS were analyzed and then recommendations were made as an alternative to minimize the occurrence of rod string damage. After analyzing the parameters that can cause rod string damage on 41 well samples in SS field, the cause of the breakdown of rod string is fluid pounding for 37 samples well, while the causes for 4 samples of other wells is not detected. After that, recommendation efforts is done, like size down pump speed and stroke length for 9 samples of wells, size down pump size and pump speed for 6 samples of wells and size down pump speed for 22 samples well. As for the undetected cause 4 samples of wells, is recommended to do proactive well service.
Dehydration Simulation of Natural Gas by using Tri Ethylene Glycol
Authors: Farda Eric
Published: October 2018

Water content in natural gas poses threat to process facilities such as column distillation. Natural gas from reservoirs usually contains water vapor, the presence of water vapor in gas processing causes bad impact to process facilities. Dry Gas composition data was taken from Salamander Energy. Optimization of natural gas dehydration using Tri Ethylene Glycol was carried out using Aspen HYSYS V8.6 with Peng-Robinson fluid package. The natural gas dehydrating plant was designed with operating conditions of 394 bar and 460C and 10 MMSCFD and 6.8 MMSCFD gas flow rate were inputted. Results obtained from HYSYS simulation shows. Three different TEG flowrates were used for this simulation. Results obtained from simulation that . For the purpose of running the plant economically, the minimum flow rate of TEG which will reduce the water content to within the limit of pipeline specification, is very important and the result obtained showed that a minimum of 3 m3/h of TEG is required to reduce the water content of a gas stream of 10MMSCFD to 6.8lb/MMSCFD, which is within the limit of 6-7lb/MMSCFD, this value when compare to gas plant which uses 15m3/h for the gas stream of 10MMSCFD to achieve the same water  content  specification is far lower.  Values below  this flow  rate  (3.5m3/h)  may not reduce the water content to the specified limit.
Spin-Forbidden Channels in Reactions of Unsaturated Hydrocarbons with O(3P)
Authors: Pokhilko Pavel , Shannon Robin , Glowacki David , Wang Hai , Krylov Anna I.
Published: October 2018

Electronic structure of four prototypical Cvetanovic diradicals, species derived by addition of O(3P) to unsaturated compounds, is investigated by high-level electronic structure calculations and kinetics modeling. The main focus of this study is on the electronic factors controlling the rate of inter-system crossing (ISC), minimal energy crossing points (MECPs) and spin-orbit couplings (SOCs). The calculations illuminate significant differences in the electronic structure of ethylene- and acetylene-derived compounds and a relatively minor effect due to methylation. The computed MECPs heights and SOCs reveal different mechanisms of ISC in ethylene- and acetylene-derived species, thus explaining variations in the observed branching ratios between singlet and triplet products and a puzzling effect of the methyl substitution. In the ethylene- and propylene-derived species, the MECP is very low and the rate is controlled by the SOC variations, whereas in the acetylene- and propyne-derived species the MECP is high and the changes in the ISC rate due to methyl substitutions are driven by the variations in MECP heights.
The Protein’s Role in Substrate Positioning and Reactivity for Biosynthetic Enzyme Complexes: the Case of SyrB2/SyrB1
Authors: Mehmood Rimsha , Qi Helena W. , Steeves Adam H. , Kulik Heather
Published: October 2018

Biosynthetic enzyme complexes selectively catalyze challenging chemical transformations, including alkane functionalization (e.g., halogenation of threonine, Thr, by non-heme iron SyrB2). However, the role of complex formation in enabling reactivity and guiding selectivity is poorly understood, owing to the challenges associated with obtaining detailed structural information of the dynamically associating protein complexes. Combining over 10 ms of classical molecular dynamics of SyrB2 and the acyl carrier protein SyrB1 with large-scale QM/MM simulation, we investigate the substrate–protein and protein–protein dynamics that give rise to experimentally observed substrate positioning and reactivity trends. We confirm the presence of a hypothesized substrate-delivery channel in SyrB2 through free energy simulations that show channel opening with a low free energy barrier. We identify stabilizing interactions at the SyrB2/SyrB1 interface that are compatible with phosphopantatheine (PPant) delivery of substrate to SyrB2. By sampling metal–substrate distances observed in experimental spectroscopy of native SyrB2/SyrB1-PPant-S-Thr and non-native substrates, we characterize essential protein–substrate interactions that are responsible for substrate positioning, and thus, reactivity. We observe the hydroxyl sidechain and terminal amine of the native Thr substrate to form cooperative hydrogen bonds with a single N123 residue in SyrB2. In comparison, non-native substrates that lack the hydroxyl interact more flexibly with the protein and therefore can orient closer to the Fe center, explaining their preferential hydroxylation and higher turnover frequencies.
Pulse wave velocity and other indicators of arterial stiffness in hypertension comorbidity and chronic obstructive pulmonary disease
Authors: Aksenova T A , Gorbunov V V , Tsarenok S Yu
Published: October 2018

The aim is to study pulse wave velocity (PWV) and other parameters of arterial stiffness in patients with comorbid arterial hypertension (AH) and chronic obstructive pulmonary disease (COPD). Materials and methods. 32 patients with a combination of AH and COPD (group 1), 30 patients with isolated hypertension (group 2), 18 patients with isolated COPD (group 3), 30 healthy subjects (control group) were examined. Applanation tonometry and pulse wave contour analysis at the carotid-femoral segment were made by SphygmoCor (AtCor Medical). Results. Aortic systolic blood pressure in patients with the combination of hypertension and COPD was higher compared to the group of the patients with isolated hypertension by 9.83% (p=0.02), and the patients with COPD by 41.5% (p = 0.000042), respectively. Central pulse pressure in the first group was higher compared to the second group by 29.58% (p=0.00022), in the third group - by 53.4% (p=0.0029). The combination of hypertension and COPD (β=0.42, p=0.00019), age (β=0.39, p=0.0002) and the level of aortic pulse pressure (β=0.54, p=0.001) were marked as independent factors of PWV increasing according to the multiple regression analysis. Conclusion. In patients with a combination of hypertension and COPD the increase in PWV, systolic and pulse pressure in the ascending aorta was observed, compared to patients with isolated hypertension, isolated COPD and the control group during applanation tonometry.
Hemochromatosis - modern condition of the problem
Authors: Voloshina N B , Osipenko M F , Litvinova N V , Voloshin A N
Published: October 2018

The iron overload syndrome can be associated with various acquired states and hereditary factors. Hereditary hemochromatosis is the most common genetic disorder. Without therapeutic intervention the disease can lead to the development of life-threatening complications such as cirrhosis, hepatocellular carcinoma. The article presents data on pathogenesis, diagnosis and treatment of hereditary hemochromatosis. Own clinical observation is given.
Application of bacterial therapeutic vaccine Immunovac-VP4 in the treatment of pollinosis
Authors: Kostinov M P , Poddubikova A M , Magarshak O O , Poddubikov A V
Published: October 2018

In-depth study of the function and structure of the lymphoid tissue of the gastrointestinal tract and respiratory tract opens wide opportunities for the use of mucosal vaccines to improve immunity to various infectious agents. One such drug is The immunovac-VP4 vaccine containing pathogen-associated molecular structures (PAMSs) of microorganisms. They are the antigens of Klebsiella pneumoniae, Proteus vulgaris, Escherichia coli, Staphylococcus aureus. Discovered in many studies and experiments, the ability of the vaccine to induce innate immunity provides opportunities for prevention and treatment of both infections and allergic diseases, because it promotes the switching of Th2 immune response to Th1. The aim of the study was to study the effectiveness of the complex use of bacterial therapeutic vaccine Immunovac-VP4 and allergen-specific immune therapy (ASIT) in pollinosis in children and adults. Materials and methods. Bacterial therapeutic vaccine Immunovac-VP4 was used annually, nasal and oral administration in patients before the course of ASIT standardized aqueous-salt solutions of allergens. Results. The therapeutic application of bacterial vaccines, Immunoac-ВП4 before the course ASIT has helped to reduce the frequency of acute respiratory infections in 8,5 times in comparison with the control group. Clinical efficacy of complex treatment according to the results of the survey of patients in 7 years after the start of therapy was 90%. There was a significant decrease In IgG4 to causally significant allergens, General immnunoglobulin E (IgE) and a tendency to decrease IgE. Conclusion. The use of bacterial therapeutic vaccine Immunovac-VP4, which is a natural ligand of toll-like receptors in combination with ASIT, seems to be an effective and promising direction in the treatment of allergic diseases.
Expression of DROSHA and DICER genes in peripheral blood leukocytes in lung sarcoidosis
Authors: Malysheva I E , Balan O V , Tikhonovich E L , Volkova T O
Published: October 2018

Aim. To study the expression level of the genes DROSHA and DICER in peripheral blood leukocytes (PBL) of patients with sarcoidosis of the lungs Materials and methods. The study included 32 patients diagnosed with persistent lung sarcoidosis (mean age 41.56±1.27 years) and 36 healthy donors (control; mean age 42.79±1.95 years). The level of expression of messenger RNA (mRNA) of the genes DROSHA and DICER were determined in PBL of healthy donors and patients with sarcoidosis of the lung by polymerase chain reaction in real time. Results. As a result of the conducted researches it is established that the level of drosha gene expression in PBL patients with sarcoidosis of lungs is significantly reduced in comparison with the control (p
Verification of zinc role in pathophysiology of chronic obstructive pulmonary disease
Authors: Shevcova V I , Zujkova A A , Pashkov A N , Kotova Ju A , Shevcov A N
Published: October 2018

Aim. Determination of the level of zinc and its fractions, as well as the enzyme neutrophilic elastase and albumin in persons suffering from chronic obstructive pulmonary disease (COPD), as well as smoking actively and passively. Materials and methods. The study involved 30 patients with a diagnosis of COPD and 90 healthy persons (60 of them smoking at the present time, 30 - no) who underwent spirometry and determination of zinc levels and its pools, albumin, and neutrophil elastase. All data are subject to statistical processing. Results. It is determined that the studied parameters differ significantly in the groups of smokers with COPD, healthy smokers and non-smokers, and correlate with the volume of forced exhalation for 1 second as a percentage of the due. Conclusion. The revealed regularities make it possible to consider the indicator "share of bound zinc fraction" introduced in the study as a screening criterion in diagnosing COPD in smokers.
Disease associated with immunoglobulin g
Authors: Chuchalin A G
Published: October 2018

Diseases associated with disorders of immunoglobulin g synthesis and its subclasses are described. The analysis of the role of both deficiency and its increased production in the diagnosis and treatment of a number of diseases in humans.
Analysis of compliance dynamics in patients with chronic obstructive pulmonary disease on the background of vaccination against pneumococcal infection
Authors: Jgnatova G L , Antonov V N
Published: October 2018

Aim. The analysis of the dynamics of compliance in patients with chronic obstructive pulmonary disease (COPD) on a background of vaccination. Material and Methods. A total of 394 male patients are covered by this study. The main endpoints of observation are as follows: 1. To evaluate the effectiveness It’s important the dynamics of scores for mMRC, FEV1, the number of exacerbations, hospitalizations, the number of pneumonia cases. 2. To assess compliance it’s necessary to conduct a test for adherence to the Moriska-Green questionnaire. For vaccine prophylaxis, 13-valent conjugated pneumococcal vaccine Prevenar-13 and a 23-valent polysaccharide vaccine Pnevmo23 were used. The dynamics of changes in the parameters studied was evaluated within 4 years of the therapy initiation. Results. The inclusion of vaccine prophylaxis of PCV13 in the patient management plan allows to reduce a degree of dyspnea and stabilize the main functional parameters of the respiratory system not only in the short term, but also for at least next 4 years. PCV13 vaccination of can be considered as a basic therapy along with bronchodilator therapy. The use of vaccine prophylaxis PCV13 significantly increases the compliance and adherence of patients to a therapy. Conclusions. The use of vaccine prophylaxis PKV13 significantly increases patients ' compliance and adherence to the therapy.
Chronic obstructive pulmonary disease and cerebrovascular diseases: functional and clinical aspect of comorbidity
Authors: Geltser B I , Kurpatov I G , Kotelnikov V N , Zayats Yu V
Published: October 2018

Literature data of chronic obstructive pulmonary disease (COPD) and cerebrovascular diseases (CVD) comorbidity are represented in this review. Key aspects of this interaction and its importance for clinical medicine have been considered. CVD and COPD are the main mortality factors in adults, which contribute to great economic wastes. The incidence of chronic cerebral ischemia for COPD patients is almost three times as high as for general population. The incidence of ischemic stroke for COPD patients is 1,2 times higher than in general population. For hemorrhagic stroke and subarachnoid haemorrhages, this figures are 1,3 and 1,46 respectively. Chronic systemic inflammation, tissue hypoxia and oxidative stress play the crucial role in respiratory and cerebrovascular comorbidity. Metabolites of these processes (especially proinflammatory cytokines, reactive oxygen species, C-reactive protein and some neurotrophins) increase the permeability of blood-brain barrier, destroy brain cells and activate atherogenesis in pre - and intracerebral arteries. Endothelial dysfunction affects autoregulation of cerebral circulation. Systemic symptoms of COPD are closely associated with different structural-functional disorders of the brain such as reduction in white matter integrity, grey matter volume reduction and cerebral microbleeds. Also, venous encephalopathy is developed as a result of intrathoracic pressure elevation and stasis in superior vena cava system. These processes result in neurological symptomatology. The intensity of symptoms depends on COPD severity. The occurrence of cognitive impairment, psychic tension, depression, panic disorders also increases. However COPD and CVD comorbidity is an important problem of modern medicine, pathophysiologic mechanisms and clinic aspects of this problem remain unresolved. Understanding of their role opens perspectives for rational pharmacotherapy.
Pulmonary vasculitis: diagnosis and treatment
Authors: Anaev E Kh , Baranova I A , Belevsky A S
Published: October 2018

Pulmonary vasculitis is a group of rapidly progressing severe diseases characterized by vascular inflammation, destruction and necrosis of the pulmonary tissue. The pathological process in the lungs varies from diffuse alveolar hemorrhage to inflammation of the parenchyma, pleural effusion, thrombotic and thromboembolic complications. Depending on the size of the affected vessels, vasculites are divided into vasculites of large, medium and small vessels. Most frequently the lung is found in the small vessels vasculitis, including ANCA-associated vasculitis [granulomatosis with polyangiitis (GP), eosinophilic granulomatosis with polyangiitis (EGPA) and microscopic polyangiitis (MPA)] and the disease is glomerular basement membrane (goodpasture syndrome). Clinical examination of other systems and organs involved in the pathological process, including the skin and kidneys, as well as the detection of autoantibodies can improve approaches to early diagnosis and treatment of vasculitis. Treatment of life-threatening pulmonary bleeding and irreversible damage to organs, especially the kidneys, requires rapid diagnosis of these conditions. Vasculitis is a rare disease with lesions of many organs, and methods of their treatment, including biological, are rapidly developing, which requires the cooperation of doctors of various specialties and specialized centers to achieve better control of the disease.
Results of program acute myeloid leukemia therapy use in National Medical Research Center for Hematology of the Ministry of Health of Russian Federation
Authors: PAROVICHNIKOVA E N , LOUKIANOVA I A , TROITSKAYA V V , DROKOV M Y , LOBAOVA T I , KUZMINA L A , SOKOLOV A N , KOKHNO A V , FIDAROVA Z T , BASKHAEVA G A , GAVRILINA O A , VASILYEVA V A , OBUKHOVA T N , KUZNETSOVA S A , SUDARIKOV A B , DVIRNIK V N , GALTSEVA I V , DAVIDIVA J O , KULIKOV S M , SAVCHENKO V G
Published: October 2018

Objective. To analyze treatment results of 172 patients with acute myeloid leukemia (AML) aged 18-60 years in National Medical Research Center for Hematology of MHRF. Materials and methods. Inductive and consolidation program for 139 (80%) patients was based on a standardized protocol: 4 courses “7+3” with different anthracycline use (2 courses of daunorubicin, idarubicin, mitoxantrone) and continuous use of cytarabine on the second inductive course. In 20% of patients cytarabine courses at the dose of 1 g/m2 2 times a day for 1-3 days combined with idarubicin and mitoxantrone were used as two consolidation courses. Allogenic bone marrow transplantation was performed in the first complete remission (CR) period in 40% of patients. Results. The frequency of CR achievement in all patients was 78.6%, refractory forms were observed in 13.9% of patients, early mortality - in 7.5% of patients. Seven-year overall survival (OS) rate was 40.7%, relapse free survival (RFS) - 43.2%. When estimating effectiveness depending on cytogenetic risk group it was demonstrated that 5-year OS and RFS in patients with translocation (8; 21) cannot be considered as satisfying, it accounted for 50 and 34%, respectively. At the same time in patients with 16th chromosome inversion (inv16) these characteristics accounted for 68.6 and 63.5%. Acquired results forced reconsidering of the consolidation program in AML patients of this subgroup. The median time to allogenic blood stem cells transplantation (allo-BSCT) in patients with first CR was 6.5 months that was taken as a reference point in landmark analysis of patients in whom allo-BSCT was not performed. Landmark analysis showed that in AML patients of favorable prognosis group allo-BSCT does not significantly reduce the probability of relapse (0 and 36%) and does not influence RFS (33 and 64%). In patients of border-line and poor prognosis allo-BSCT significantly reduces relapse probability (26 and 66%; 20 and 100%) and significantly increases a 7-year RFS (68.7 and 30%; 45.6 and 0%). Allo-BSCT also results in significant RFS increase and reduces the probability of relapse (25 and 78%) in patients in whom CR was achieved only after the second induction course. At the same time allo-BSCT does not influence patients who achieved CR after the first treatment course: 55 and 50%. Conclusion. Multivariate analysis showed that cytogenetic risk group (HR=2.3), time of CR achievement (HR=2.9), and allo-BSCT transplantation (HR=0.16) are independent factors for disease relapse prognosis after achieving CR.
The role of nelarabine in the treatment of T-cell acute lymphoblastic leukemia: literature review and own experience
Authors: DYAKONOVA Y Y , BYDANOV O I , POPOV A M , OLSHANSKAYA Y V , BOICHENKO E G , ALEYNIKOVA O V , MASCHAN M A , SHELIKHOVA L N , LITVINOV D V , KHACHATRYAN L A , PONOMAREVA N I , FECHINA L G , NOVICHKOVA G A , PASHANOV E D , KARACHUNSKIY A I
Published: October 2018

Aim. The analysis of experience of nelarabine use in refractory/relapsed T-cell acute lymphoblastic leukemia (T-ALL) depending on the immunophenotype and the line of therapy. Materials and methods. All the patients with relapsed or refractory T-ALL aged from 0 to 18 years who received treatment with nelarabine as a part of the therapeutic element R6 were included in the study. For all patients a detailed immunological analysis of leukemia cells with discrimination of immunological variants TI, TII, TIII or TIV was performed. Patients administered with nelarabine as a first therapeutic element were referred to the first-line therapy group, other patients were referred to the second-line therapy group. Nelarabine was administered as intravenous infusion at a dose of 650 mg/m2, on days 1-5. Allogeneic hematopoietic stem cells transplantation (allo-HSCT) was considered for all patients. Results. From 2009 to 2017, 54 patients with refractory/relapsed T-ALL were treated with nelarabine. Five-year event-free survival (EFS) and overall survival (OS) was 28% for all patients, cumulative risk of relapse (CIR) was 27%. EFS was significantly higher in nelarabine first-line therapy group in comparison with second-line therapy group (34±8% vs 8±8%, p=0,05). In patients after allo-HSCT EFS, OS and CIR were 51±10%, 50±10% and 39,1±9,5% accordingly. The best results were achieved in patients with TI immunophenotype. No toxicity-related mortality as well as severe neurologic complications or discontinuation of therapy associated with use of nelarabine were reported. Conclusion. The use of nelarabine is an effective strategy for the treatment of relapsed and refractory T-ALL. The best treatment outcomes were obtained in patients with TI immunophenotype and in the first-line therapy group. Optimal dosage regimens can be established during controlled clinical trials.
Diagnostics of thrombocytopenias
Authors: Mazurov A V , Khaspekova S G , Vasiliev S A
Published: October 2018

Laboratory methods used for the diagnostics of thrombocytopenias are reviewed. Differential diagnosis is usually carried out between immune and hypoproductive forms of thrombocytopenia. Immune thrombocytopenias are caused by appearance in blood of antiplatelet abtibodies and accelerated destruction of platelets sensibilized by those antibodies, and hypoproductive thrombocytopenias - by impaired platelet production in the bone marrow. Main directions of the laboratory diagnostics of thrombocytopenias - analysis of auto - and alloautoantibodies and evaluation of platelet production and turnover in the blood stream. The following methods are used for the investigation of antiplatelet antibodies: 1) measurement of platelet associated immunoglobulins; 2) determination of circulating antibodies reacting with platelets; 3) determination of antibodies using antigen specific methods - by their reactivity with isolated platelet antigens (glycoproteins). Efficacy of platelet production could be assessed by measuring in blood the amount of “young” (reticulated) platelets. One more method for the evaluation of platelet production as well as the rate of platelet turnover - measurement of plasma soluble glycocalicin, glycoprotein Ib fragment shed from the surface of platelets upon their destruction in spleen and liver. In patients with immune thrombocytopenia autoantibodies are evaluated in all cases, the percentage of reticulated platelets is significantly increased and the amount of plasma glycocalicin is within the normal range or increased. In patients with hypoproductive thrombocytopenia autoantibodies are not detected or detected at low level, the percentage of reticulated platelets is within the normal range or slightly increased and the amount of plasma glycocalicin is lowered. Diagnostics of hapten forms of immune thromocytopenias (heparin-induced thrombocytopenia and others) and of alloimmune thrombocytopenias (neonatal alloimmune thrombocytopenia in particular) are considered in the separate sections of this review.
Thrombopoietin Receptor Agonists in the Treatment of Chronic Resistant Primary Immune Thrombocytopenia: Efficacy and Safety Data in Real Clinical Practice
Authors: PTUSHKIN V V , VINOGRADOVA O Yu , PANKRASHKINA M M , CHERNIKOV M V , ARSHANSKAYA E G , TKACHENKO N E
Published: October 2018

Objective: To analyze the long-term efficacy and safety of ATR in adult patients with primary resistant ITP in real-world clinical practice. Materials and methods.The article contains long-term results analysis of ATR application under real clinical practice conditions in 138 patients (40 men and 98 women) whose median age at the beginning of therapy was 59 (18-86) years. Two ATR medicines-romiplostim (100 patients) and eltrombopag (38 patients) were used. Results. During the first month of therapy, the median platelet count in the romiplostim group increased from 17·109 / L to 60·109 / L (9-600·109 / L), and the elethrombopag from 16.109 / L to 56.109 / L (9-400·109 / L). The minimal response (reaching platelet counts over 30·109 / L) was achieved in 92% of cases in both groups. Partial response (achievement of platelet count more than 50·109 / L) was achieved in 91 and 84% of patients in the rhombostim and eltrombopag groups, respectively. The frequency of complete response (an increase in platelet counts above 100·109 / L) was noted somewhat more often in the rhyploistim group-69% compared to 47% in the eltrombopag group (P = NS). Most patients demonstrated a long-term stable effect in the form of an increase in blood platelet count to a safe level during months and years of ATR treatment. The achievement of at least partial remission for 3 months or more was 70 and 71% in romiplostim and elthrombopag groups, respectively. Patients who started ATR- therapy are currently continuing treatment: 51% - in romiplostim group and in eltrombopag group-39%. The main reason of discontinuation the initially effective therapy were the loss of platelet response, toxicity, withdrawal from treatment (withdrawal with preservation of remission) and patients death. The tolerability of drugs with long-term admission was satisfactory. The most common AE were headache, bone pain, thrombosis, increased blood pressure and petechial hemorrhagic eruptions. The overall incidence of complications did not differ significantly between the romiplostim and eltrombopag groups -15.6 and 15.8%, respectively. Conclusion. Long-term ATR-therapy using in patients with resistant chronic ITP is an effective and largely safe treatment option.
Successful experience of treatment of a patient with generalized non-GCB- DLBCL using the R-mNHL-BFM-90 protocol with lenalidomide: case report and review of literature
Authors: GABEEVA N G , ZVONKOV E E , KOROLEVA D A , CHUKAVINA M M , OBUKHOVA T N , KOVRIGINA A M
Published: October 2018

Diffuse large B-cell lymphoma is categorized by gene expression profiling into germinal center (GCB) and activated B-cell (ABC) subtype, also referred to as non-germinal center B-cell (non-GCB) by immunohistochemistry. ABC DLBCL is characterized by NF-κB pathway activation and high expression of IRF4/MUM1, a key transcription factor in B cell differentiation. Patients with ABC DLBCL have a significantly worse outcome when treated with standard chemotherapy (R-CHOP). Lenalidomide have shown activity in the ABC-DLBCL in combination with R-CHOP. But about 40% of patients remain resistant. We present the experience of treatment of a patient with generalized non-GCB-DLBCL using the intensive protocol R-mNHL-BFM-90 with lenalidomide.
Character Diversity in Digital and Non-Digital Games
Authors: To Alexandra , McDonald Joselyn , Holmes Jarrek , Kaufman Geoff , Hammer Jessica
Published: October 2018

We explore how digital and non-digital games express diversity through characters, understood as representations of marginalized groups to which the player may or may not belong. We identify a range of techniques using visual design, abstract character representation, delineation of game setting and roles, conversation design, and the design of rules and systems. We illustrate these techniques with exemplar games identified through consultation with experts. This analysis yields four key recommendations for designing diversity across a range of game platforms: match diversity affordances to player needs; draw strengths from both the digital and non-digital realms; design for conversation; and consider player diversity. We conclude by proposing diversity as an end-to-end process in both game research and design.
DiGRA Chapter Diversity
Authors: Wirman Hanna
Published: October 2018

This paper focuses on the perceived value and importance of the regional chapters of Digital Games Research Association (DiGRA). Drawing on a survey conducted among chapter representatives, the viewpoints of nine regional chapter representatives are discussed, particularly from the point of view of how they contribute to better diversity and inclusiveness in such a large international organization. It answers two questions: 'What are the advantages of having regional chapters?' and 'What exactly constitutes �regional� in the context of DiGRA chapters?' In so doing, the paper establishes regional chapters as important junctures in catering for a wide audience beyond those able and interested in participating in annual DiGRA conferences or partaking in other international events.
O jogo das palavras-semente e outros jogos para jogar com palavras, de Carlos Rodrigues Brandão. São Paulo: Cortez, 2015, 167 p.
Authors: Vercelli Ligia De Carvalho Abões
Published: October 2018

resenha
The Correlation between Self-Efficacy and Time to Degree Completion of Educational Leadership Doctoral Students
Authors: S McBrayer Juliann , Denlea Melton Teri , W Calhoun Daniel , Dunbar Matthew , Tolman Steven
Published: October 2018

Aim/Purpose: This study examined an Ed.D. program redesign to address time to degree completion. The aim was to emphasize the need to improve students’ academic writing and embody a scholarly practitioner approach to research.

Background: Doctoral programs have the highest attrition of graduate programs, with almost half of the students taking six to seven years to complete.

Methodology: An ex-post-facto correlational research design examined self-efficacy and educational leadership doctoral students perceived versus actual program progression. This was statistically determined through Pearson’s correlation coefficients and a t-test analysis.

Contribution: This study provides other doctoral programs who are struggling with time to degree completion a model to consider as they contemplate a program redesign.

Findings: Ed.D. students in the 2014 and 2015 cohorts reported high self-efficacy (3.62 and 3.57 respectively, out of 4.00). There was a statistically significant difference in the number of defenses completed per semester based on the program redesign.

Recommendations for Practitioners: Ed.D. programs should consider using a scholarly practitioner approach. This focus may lead to faster rates of degree completion and better prepare students to solve problems of practice in their practitioner setting.

Recommendation for Researchers: While the results are promising as to expediting time to degree completion, like most doctoral programs it does not seem to impact overall completion rates of the program as a whole, thus, warranting further research.

Impact on Society: Expediting time-to-completion enables students to graduate sooner. This will yield cost savings to the student, free up faculty resources, and most importantly prepare students to sooner serve as scholarly practitioners.

Future Research: Future research should continue to examine time to degree completion, as well as students’ lived experiences and examine how those shape doctoral students’ efforts and abilities in their Ed.D. work from start to program completion.
“Çocuk” Sözcüğünün Etimolojisi Üzerine
Authors: AYDEMİR Hakan
Published: October 2018

Bu çalışmada esas olarak çocuk sözcüğünün kökeni

ele alınmaktadır. Fakat sözcüğün yapısını daha iyi anlamamıza yardım edeceği ve

analoji teşkil edeceği için önce Türkiye Türkçesinde ‘çocuk’, ‘bebek’, ‘yavru’

anlamına gelen bazı Türkçe sözcükler de anlam ve köken bakımından mercek altına

alınmaktadır. Bu bağlamda anlam ve biçimbilgisi bakımından tartışmalı olan veya

kökeni pek açık olmayan bala, bebe, bebek,

enik,

oğul,

döl,

uşak,

yavru

sözcüklerinin köken ve anlam açıklamaları yapılmaktadır. Çocuk sözcüğü üzerine

fikir beyan eden araştırmacıların görüşleri tanıtıldıktan sonra çocuk

sözcüğü sesbilimsel, anlambilimsel ve biçimbilimsel açılardan ayrıntılı olarak

incelenmektedir. Çalışma, çocuk sözcüğünün kökenini nihai

çözüme kavuşturmak yanında bu sözcüğün asıl anlamının ‘domuz yavrusu’ olup

olmadığı konusunda uzun zamandır süregelen tartışmalara da bir son vermeyi

amaçlamaktadır. Bu çalışmada yapılan ayrıntılı kökenbilimsel incelemelerin

sonuçlarına dayanarak, enik, döl, yavru gibi sözcüklerin

‘hayvan yavrusu’ anlamının ikincil olarak sonradan ortaya çıktığı, çocuk

sözcüğünün asıl anlamının ise sanıldığı gibi ‘domuz yavrusu’ olmadığı sonucuna

varılmıştır. Ayrıca çocuk sözcüğünün Anadolu ağızlarındaki ‘domuz; domuz yavrusu;

bebek, çocuk’ anlamına gelen çoçka, çoçga, çoşka,

çoşga

vb. gibi sonradan ortaya çıkan değişkeleri yanında, sözcüğün türediği

isim kökü olan Tkm. çāga ‘çocuk, bebek’, Mo. çaga, çaka, DS cağa,

çova,

çoa,

çoğa,

çoğ

‘çocuk’ ve benzeri anlamlar taşıyan TTü. çoluk (çocuk), Tkm. çovluk,

DS çacuk

~ cacık

biçimleri de inceleme altına alınmaktadır. Çalışmanın en sonunda, çocuk

sözcüğü ve türevleri için bu çalışmada sunulan kökenbilimsel çözüm önerileri

bir şemada kronolojik olarak gösterilmiştir. 
Esrârını Molino'dan aldım / Çaldım velî mîrî malı çaldım: Antonio Mascis'in İtalyanca-Türkçe Sözlüğü Üzerine (1677)
Authors: YAĞMUR Ömer
Published: October 2018

Türkçe transkripsiyon metinleri Batı Türkçesinin

Osmanlı sahası içerisinde, Arap alfabesinin gölgelediği bazı fonetik ve

morfolojik değişim ve gelişmeleri görmemizi sağlayan önemli verilerdir.

Genellikle Batılı Türkologlar tarafından yapılmış çalışmalarla bu metinler dil

alanında uzmanlaşmış araştırıcıların istifadesine sunulmuştur. Benim çalışmam

17. yüzyıl transkripsiyon metni olan, 12 yıl İstanbul'da bulunmuş İtalyan

çevirmen Antonio Mascis'in 1677 yılında Floransa'da bastırdığı Vocabolario Toscano, e Tvrchesco adlı

sözlüğü üzerine olacaktır. Toskana Grandükü Cosimo iii'e (d.1642-ö.1723) ithaf

edilen sözlük XXXIV+38+290 sayfadan oluşur. Grandük'e övgü ile başlayan ilk

bölümün ardından ikinci bölümde Türkçenin dilbilgisi kuralları ele alınır.

Mascis'in grameri Vladimir Drimba'ya göre 1641'de Roma'da basılan Giovanni Molino'nun Dittionario della lingua Italiana, e Turchesca'sının içinde yer

alan Türkçe gramerinin üzerinde değişiklik yapılmış bir imitasyonundan

ibarettir. Drimba, aynı zamanda sözlüğün de imitasyon olduğunu belirtir. O

dönemde intihalin yaygın olduğunu ve hatta telif hakkı kavramının olmadığını

düşünürsek bu gayet normal karşılanmalıdır. Fakat Mascis'in sözlüğü gerek

Türkçe kelimelerin telaffuzu gerekse yeni Türkçe kelimeler ilavesi ve İtalyanca

madde başları yönüyle Molino'dan bir hayli farklılıklar gösterir. Mascis'in

sözlüğü özgün bir eser olmasa dahi Molino'nun kötü bir taklidi değil, 1641'den

1677'ye İstanbul ağzındaki bazı değişmeleri gösteren gözden geçirilmiş yeni bir

baskı olarak düşünülebilir. Bugünün yaklaşımıyla, Mascis'in en büyük hatası

eserinde hiçbir şekilde Molino'dan bahsetmemiş olmasıdır. Araştırmam bahsedilen

bu farklılıkları ortaya koymayı amaçlamaktadır.
Bulgaristan’daki Türbelerin Güncel Durumu Üzerine Bir Değerlendirme
Authors: GÜLEÇ İsmail
Published: October 2018

1389-1978 yılları arasında Osmanlı Devleti’ne

bağlı birkaç vilayet olan Bulgaristan’da Türkler binlerce mimari eser vücuda

getirmişlerdir. Bunlardan bir kısmı zamanla yıkılırken büyük bir kısmı 1877-8

Osmanlı-Rus Savaşı’nın ardından Ruslar tarafından yıkılmış, bir kısmı da Bulgar

milliyetçileri tarafından sonraki yıllarda yakılmış ve yıkılmıştır. Üç bini

aşkın eserden geriye kalanların sayısı bugün üç yüzü bulmamaktadır. Bu

makalede; Bulgaristan’a yapılan iki seyahatte tespit edilen ve günümüze kadar

kalmayı başarmış türbe ve tekkelerin bugünkü durumu üzerinde durulacak, ortak

özelliklerine göre birtakım tasniflerde bulunulacaktır. Türbelerin mevcut

durumları ortaya konularak konuya dikkat çekilecek ve bundan sonra

yapılacaklara bir nebze de olsa ışık tutulmaya çalışılacaktır.
Türkçe Öğretmenlerinin Yazınsal Metinleri Anlamaya Yönelik Etkinlikler ile İlgili Görüşlerinin İncelenmesi
Authors: CİN ŞEKER Zeynep
Published: October 2018

Bu çalışmanın konusu, Türkçe öğretmenlerinin

Türkçe ders kitaplarında yer alan yazınsal metinleri anlamaya yönelik

etkinlikler ile ilgili görüşlerini incelemektir. Çalışmanın konusu bağlamında,

Türkçe öğretmenlerinin metni anlamaya yönelik etkinliklere ilişkin görüşlerini,

hâlihazırda uygulanan metni anlama çalışmalarına alternatif yaklaşım

önerilerini belirlemek ve bu görüşler doğrultusunda bir değerlendirme yapmak

amaçlanmıştır. Çalışmada nitel araştırma deseni kullanılmıştır. Çalışmanın

araştırma grubu, Erzurum il merkezinde bulunan ortaokullarda görev yapan Türkçe

öğretmenleri arasından uygun örnekleme yöntemi ile belirlenmiştir. Çalışmanın

verileri ise beş açık uçlu soru ile oluşturulan “Yarı Yapılandırılmış Öğretmen

Görüşme Formu” ile toplanmıştır. Araştırmanın sonucunda Türkçe öğretmenlerinin,

yazınsal metinleri çözümlemeye yönelik etkinliklerin önemli olduğunu

düşündükleri ancak hâlihazırda uygulanan metin çözümleme çalışmalarını yetersiz

ve eksik buldukları görülmüştür. Öğretmenlerin bu çalışmalara alternatif olarak

öğrencilerin eleştirel ve yaratıcı düşünme becerilerini geliştirecek, gerçek

hayatla bağlantılı çalışmalara yöneldikleri sonucuna ulaşılmıştır.
Zeynel Besim Sun’un Çakıcı Mehmet Efe Romanında Başkahraman Üzerine Tespitler
Authors: SAĞLAM M. Halil
Published: October 2018

Çakıcı

Mehmet Efe romanı 1934 yılında İzmir Ticaret

Postası Gazetesi’nde tefrika halinde yayımlanmıştır. Roman, Çakıcı Mehmet Efe

hakkında yazılan ilk roman olması ve dönemin sosyal, siyasal ve kültürel

özelliklerini yansıtması açısından önemlidir. Çakıcı Mehmet Efe’nin yaşadığı

Ege köylerinde yapılan derleme çalışması üzerine kurgulanan romanda, vaka

örgüsüyle ilgili ansiklopedik bilgiler ve fotoğraflar da bulunmaktadır. Çakıcı

Mehmet Efe hakkında bir romanı bulunan Yaşar Kemal de bu romanın Çakırcalı

üstüne yazılmış en ilginç kitaplardan bir olduğunu ifade etmektedir. Romanın

bir başka özelliği de Ege’de eşkıyalık ve Çakıcı Mehmet Efe hakkında yapılan

akademik çalışmalarda kaynak olarak kullanılmasıdır. Bu çalışmanın temel amacı

Çakıcı Mehmet Efe’nin soylu eşkıya tipojisine uyan ve aykırı düşen karakter

özelliklerini tespit etmektir. Nitel araştırma metodunun uygulandığı çalışmada

elde edilen bulgular, reel tarihî kaynaklarla karşılaştırılmıştır. Yapılan

araştırma sonucunda Çakıcı Mehmet Efe’nin soylu eşkıya tipolojisiyle örtüşen

vasıflar taşımakla birlikte zamanla bu vasıfları yitirdiği tespit edilmiştir.

İçlerinde çocuk, kadın ve askerlerin de bulunduğu binden fazla insanı

acımasızca öldüren Çakıcı Mehmet Efe’nin Türk romanlarında, sinemalarında ve

tiyatrolarında saygıyla ve övgüyle anlatılması bir eleştiri konusudur.

Cumhuriyet’in ilk yıllarından beri devam eden bu olumlu algının yeniden

değerlendirilmesi önem arz etmektedir.