bluuebunny/crossref_metadata_2025 huggingface dataset:
Time-Restricted Feeding Attenuates Metabolic Dysfunction-Associated Steatohepatitis and Hepatocellular Carcinoma in Obese Male Mice
Authors: Das Manasi , Kumar Deepak , Sauceda Consuelo , Oberg Alexis , Ellies Lesley G. , Zeng Liping , Jih Lily J. , Newton Isabel G. , Webster Nicholas J. G.
Published: April 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) has surpassed the hepatitis B virus and hepatitis C virus as the leading cause of chronic liver disease in most parts of the Western world. MASLD (formerly known as NAFLD) encompasses both simple steatosis and more aggressive metabolic dysfunction-associated steatohepatitis (MASH), which is accompanied by inflammation, fibrosis, and cirrhosis, and ultimately can lead to hepatocellular carcinoma (HCC). There are currently very few approved therapies for MASH. Weight loss strategies such as caloric restriction can ameliorate the harmful metabolic effect of MASH and inhibit HCC; however, it is difficult to implement and maintain in daily life, especially in individuals diagnosed with HCC. In this study, we tested a time-restricted feeding (TRF) nutritional intervention in mouse models of MASH and HCC. We show that TRF abrogated metabolic dysregulation induced by a Western diet without any calorie restriction or weight loss. TRF improved insulin sensitivity and reduced hyperinsulinemia, liver steatosis, inflammation, and fibrosis. Importantly, TRF inhibited liver tumors in two mouse models of obesity-driven HCC. Our data suggest that TRF is likely to be effective in abrogating MASH and HCC and warrant further studies of time-restricted eating in humans with MASH who are at higher risk of developing HCC.
Proteomic Analysis of Spatial Heterogeneity Identifies HMGB2 as Putative Biomarker of Tumor Progression in Adult-Type Diffuse Astrocytomas
Authors: Becker Aline P. , Becker Valesio , McElroy Joseph , Webb Amy , Han Chunhua , Guo Yingshi , Bell Erica H. , Fleming Jessica , Popp Ilinca , Staszewski Ori , Prinz Marco , Otero Jose J. , Haque Saikh Jaharul , Grosu Anca-Ligia , Chakravarti Arnab
Published: April 2024

Although grading is defined by the highest histological grade observed in a glioma, most high-grade gliomas retain areas with histology reminiscent of their low-grade counterparts. We sought to achieve the following: (i) identify proteins and molecular pathways involved in glioma evolution; and (ii) validate the high mobility group protein B2 (HMGB2) as a key player in tumor progression and as a prognostic/predictive biomarker for diffuse astrocytomas. We performed liquid chromatography tandem mass spectrometry (LC-MS/MS) in multiple areas of adult-type astrocytomas and validated our finding in multiplatform-omics studies and high-throughput IHC analysis. LC-MS/MSdetected proteomic signatures characterizing glioma evolution towards higher grades associated with, but not completely dependent, on IDH status. Spatial heterogeneity of diffuse astrocytomas was associated with dysregulation of specific molecular pathways, and HMGB2 was identified as a putative driver of tumor progression, and an early marker of worse overall survival in grades 2 and 3 diffuse gliomas, at least in part regulated by DNA methylation. In grade 4 astrocytomas, HMGB2 expression was strongly associated with proliferative activity and microvascular proliferation. Grounded in proteomic findings, our results showed that HMGB2 expression assessed by IHC detected early signs of tumor progression in grades 2 and 3 astrocytomas, as well as identified GBMs that had a better response to the standard chemoradiation with temozolomide.
Long-Term Intake of Proton-Pump Inhibitors Could Be Associated with an Increased Incidence of Liver Cancer in Women
Authors: Loosen Sven H. , Jördens Markus S. , Leyh Catherine , Luedde Tom , Roderburg Christoph , Kostev Karel
Published: April 2024

Background: Proton pump inhibitors (PPIs) are among the most commonly prescribed drugs in gastroenterology. Although PPIs are mostly well tolerated, long-term PPI intake has been linked with diabetes mellitus, osteoporosis and infectious disease. In the present study, we evaluated a potential association between PPI intake and a subsequent diagnosis of liver cancer in a large real-world cohort of outpatients in Germany. Methods: A total of 1766 patients with liver cancer, as well as 8830 propensity-score-matched controls, were identified from the Disease Analyzer database (IQVIA). The outcome of the study was the association between PPI use and a subsequent diagnosis of liver cancer, which was evaluated using multivariable logistic regression analyses. Results: Overall, 42.9% of the liver cancer patients and 39.0% of the controls received at least one PPI prescription before the index date. PPI prescriptions at any time before the index date were associated with an increased risk of subsequent liver cancer (OR: 1.18; 95% CI: 1.06–1.31). The positive association was observed in all age groups, as well as in women and men, but only in women (OR: 1.30; 95% 1.09–1.55) did it reach the predefined level of significance (p < 0.01). When considering the duration of PPI therapy, only PPI therapy for at least two years was significantly associated with an increased risk of liver cancer (OR: 1.28; 95% 1.09–1.50). In an analysis stratified by age and sex, this association was strongest in the age group < 60 years (OR: 1.99; 95% 1.21–3.26). Conclusions: Our data suggest that long-term PPI intake in women as well as in patients < 60 years might be associated with an increased risk of liver cancer. These findings support current efforts to reduce the inappropriate use of PPIs in routine clinical practice and to link PPI prescribing to a clear medical indication.
The E3 Ubiquitin Protein Ligase LINCR Amplifies the TLR-Mediated Signals through Direct Degradation of MKP1
Authors: Yokosawa Takumi , Miyagawa Sayoko , Suzuki Wakana , Nada Yuki , Hirata Yusuke , Noguchi Takuya , Matsuzawa Atsushi
Published: April 2024

Toll-like receptors (TLRs) induce innate immune responses through activation of intracellular signaling pathways, such as MAP kinase and NF-κB signaling pathways, and play an important role in host defense against bacterial or viral infections. Meanwhile, excessive activation of TLR signaling leads to a variety of inflammatory disorders, including autoimmune diseases. TLR signaling is therefore strictly controlled to balance optimal immune response and inflammation. However, its balancing mechanisms are not fully understood. In this study, we identified the E3 ubiquitin ligase LINCR/ NEURL3 as a critical regulator of TLR signaling. In LINCR-deficient cells, the sustained activation of JNK and p38 MAPKs induced by the agonists for TLR3, TLR4, and TLR5, was clearly attenuated. Consistent with these observations, TLR-induced production of a series of inflammatory cytokines was significantly attenuated, suggesting that LINCR positively regulates innate immune responses by promoting the activation of JNK and p38. Interestingly, our further mechanistic study identified MAPK phosphatase-1 (MKP1), a negative regulator of MAP kinases, as a ubiquitination target of LINCR. Thus, our results demonstrate that TLRs fine-tune the activation of MAP kinase pathways by balancing LINCR (the positive regulator) and MKP1 (the negative regulator), which may contribute to the induction of optimal immune responses.
The Role Played by Autophagy in FcεRI-Dependent Activation of Mast Cells
Authors: Pavlyuchenkova Anastasia N. , Smirnov Maxim S. , Chernyak Boris V. , Chelombitko Maria A.
Published: April 2024

The significant role of mast cells in the development of allergic and inflammatory diseases is well-established. Among the various mechanisms of mast cell activation, the interaction of antigens/allergens with IgE and the subsequent binding of this complex to the high-affinity IgE receptor FcεRI stand out as the most studied and fundamental pathways. This activation process leads to the rapid exocytosis of granules containing preformed mediators, followed by the production of newly synthesized mediators, including a diverse array of cytokines, chemokines, arachidonic acid metabolites, and more. While conventional approaches to allergy control primarily focus on allergen avoidance and the use of antihistamines (despite their associated side effects), there is increasing interest in exploring novel methods to modulate mast cell activity in modern medicine. Recent evidence suggests a role for autophagy in mast cell activation, offering potential avenues for utilizing low-molecular-weight autophagy regulators in the treatment of allergic diseases. More specifically, mitochondria, which play an important role in the regulation of autophagy as well as mast cell activation, emerge as promising targets for drug development. This review examines the existing literature regarding the involvement of the molecular machinery associated with autophagy in FcεRI-dependent mast cell activation.
Effect of Thermal Cycling or Simulated Gastric Acid on the Surface Characteristics of Dental Ceramic Materials
Authors: Pandoleon Panagiotis , Sarafidou Katia , Pouroutzidou Georgia K. , Theocharidou Anna , Zachariadis George A. , Kontonasaki Eleana
Published: April 2024

(1) Background: The presence of various dental ceramic materials with different chemical compositions complicates clinicians’ decision making, especially in cases with a highly acidic environment appearing in patients suffering from gastroesophageal reflux disease or other eating disorders. Thermal alterations in the oral cavity can also affect surface structure and roughness, resulting in variations in both degradation mechanisms and/or bacteria adhesion. The aim of the present in vitro study was to evaluate the effect of thermal cycling and exposure to simulated gastric acid on the surface roughness of different ceramics; (2) Methods: Five groups of different ceramics were utilized, and twenty specimens were fabricated for each group. Specimens were either thermocycled for 10,000 cycles in distilled water or immersed in simulated gastric acid for 91 h. The evaluation of surface roughness was performed with optical profilometry, while scanning electron microscopy, X-ray diffraction analysis and inductively coupled plasma atomic emission spectroscopy were also performed; (4) Conclusions: Based on the combination of the surface roughness profile and structural integrity, zirconia specimens presented the smallest changes after immersion in simulated gastric acid followed by lithium disilicate materials. Zirconia-reinforced lithium silicate ceramic presented the most notable changes in microstructure and roughness after both treatments.
Melamine-Modified Graphene Oxide as a Corrosion Resistance Enhancing Additive for Waterborne Epoxy Resin Coatings
Authors: Li Xin , Li Dongsheng , Chen Jie , Huo Dongxia , Gao Xin , Dong Junhui , Yin Yue , Liu Jun , Nan Ding
Published: April 2024

Waterborne epoxy resin (WEP) coatings are widely used in various fields due to their environmentally friendly properties, yet their corrosion resistance and shielding properties demand further refinement. In this work, melamine-modified graphene oxide (MGO) was synthesized using surface covalent functionalization, and a novel waterborne epoxy/modified graphene oxide coating (WEP/MGO) was prepared. The optimal modification effect was obtained by exploring different proportions of melamine, which led to significant improvements in the corrosion resistance of WEP. Furthermore, the corrosion protection efficiency of WEP/MGO coatings was systematically evaluated by examining the impact of different additions of MGO. The impedance modulus at the lowest frequency was increased from 3.77 × 108 Ω·cm2 of WEP to 2.85 × 109 Ω·cm2 after immersion in 3.5% NaCl for 48 h, when the addition of MGO was 0.1 wt.%. And the corrosion expansion at both the scratch and corrosion spot frequencies of the WEP-coated samples displayed a remarkable attenuation following exposure to salt spray for 300 h. The corrosion resistance and barrier properties of WEP coatings have been considerably enhanced.
The Effect of Intumescent Coating Containing Expandable Graphite onto Spruce Wood
Authors: Kmeťová Elena , Kačíková Danica , Kačík František
Published: April 2024

Wood, one of the materials predominantly employed in construction, possesses various advantageous properties alongside certain drawbacks, such as susceptibility to thermal degradation. To enhance wood fire resistance, one approach involves the application of flame retardants. This study compared the fire-retardant effectiveness of expandable graphite, bonded with water glass, as a coating for spruce wood against commercially available fire-retardant treatments. Spruce wood samples (Picea abies (L.) H. Karst) underwent treatment with three distinct retardants: expandable graphite in combination with water glass, Bochemit Antiflash, and Bochemit Pyro. The fire-technical characteristics of the samples were examined by a non-standard test method—a test with a radiant heat source. The experiment evaluated the fire-retardant properties by recording changes in sample mass, burning rate, and temperature difference. The best results among all flame retardants were achieved by expandable graphite in combination with water glass, in all evaluation criteria. Among all the flame retardants used, expandable graphite in combination with water glass achieved the best results in all evaluation criteria.
Study of AlN Epitaxial Growth on Si (111) Substrate Using Pulsed Metal–Organic Chemical Vapour Deposition
Authors: Hisyam Muhammad Iznul , Shuhaimi Ahmad , Norhaniza Rizuan , Mansor Marwan , Williams Adam , Mat Hussin Mohd Rofei
Published: April 2024

A dense and smooth aluminium nitride thin film grown on a silicon (111) substrates using pulsed metal–organic chemical vapor deposition is presented. The influence of the pulsed cycle numbers on the surface morphology and crystalline quality of the aluminium nitride films are discussed in detail. It was found that 70 cycle numbers produced the most optimized aluminium nitride films. Field emission scanning electron microscopy and atomic force microscopy images show a dense and smooth morphology with a root-mean-square-roughness of 2.13 nm. The narrowest FWHM of the X-ray rocking curve for the AlN 0002 and 10–12 reflections are 2756 arcsec and 3450 arcsec, respectively. Furthermore, reciprocal space mapping reveals an in-plane tensile strain of 0.28%, which was induced by the heteroepitaxial growth on the silicon (111) substrate. This work provides an alternative approach to grow aluminium nitride for possible application in optoelectronic and power devices.
New Insight into the Electronic and Magnetic Properties of Sub-Stoichiometric WO3: A Theoretical Perspective
Authors: Trioni Mario Italo , Cargnoni Fausto , Americo Stefano , Soave Raffaella
Published: April 2024

We present a theoretical investigation on the wide-band-gap semiconductor WO 3 in its room-temperature monoclinic structure. We carried out density functional theory and GGA-1/2 calculations on the bulk phase and the most stable (001) surface of the material, either in their stoichiometric form or in the presence of oxygen vacancies at various concentrations. Concerning the bulk phase, our results show how the inclusion of these defects correctly reproduces the intrinsic n-type doping of the material. The system is also found to be magnetic at reasonably high defect concentrations. As for the surface, the presence of vacancies gives rise to a magnetic behavior, whose features depend on the relative arrangement of native point defects. Oxygen vacancies are also responsible for additional tungsten oxidation states in both bulk and surface. Based on these results, we provide a rationale for the interpretation of most experimental data of this material and, possibly, other widespread transition metal oxides with similar properties and applications such as ReO 3, TiO 2, and SnO 2.
Survival Outcome Prediction in Glioblastoma: Insights from MRI Radiomics
Authors: Styliara Effrosyni I. , Astrakas Loukas G. , Alexiou George , Xydis Vasileios G. , Zikou Anastasia , Kafritsas Georgios , Voulgaris Spyridon , Argyropoulou Maria I.
Published: April 2024

Background: Extracting multiregional radiomic features from multiparametric MRI for predicting pretreatment survival in isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM) patients is a promising approach. Methods: MRI data from 49 IDH wild-type glioblastoma patients pre-treatment were utilized. Diffusion and perfusion maps were generated, and tumor subregions segmented. Radiomic features were extracted for each tissue type and map. Feature selection on 1862 radiomic features identified 25 significant features. The Cox proportional-hazards model with LASSO regularization was used to perform survival analysis. Internal and external validation used a 38-patient training cohort and an 11-patient validation cohort. Statistical significance was set at p < 0.05. Results: Age and six radiomic features (shape and first and second order) from T1W, diffusion, and perfusion maps contributed to the final model. Findings suggest that a small necrotic subregion, inhomogeneous vascularization in the solid non-enhancing subregion, and edema-related tissue damage in the enhancing and edema subregions are linked to poor survival. The model’s C-Index was 0.66 (95% C.I. 0.54–0.80). External validation demonstrated good accuracy (AUC > 0.65) at all time points. Conclusions: Radiomics analysis, utilizing segmented perfusion and diffusion maps, provide predictive indicators of survival in IDH wild-type glioblastoma patients, revealing associations with microstructural and vascular heterogeneity in the tumor.
Anthropogenic Pressures on Gorillas: A Case of Grauer’s Gorillas in Maiko National Park, the Democratic Republic of Congo
Authors: Consolee Kahindo Tulizo , Luan Xiaofeng , Cong Li
Published: April 2024

Anthropogenic activities put biodiversity under pressure, adversely affecting the forest ecosystem and wildlife habitats. Habitat disturbance and modification are among the main threats to animal populations in tropical forests. In the Democratic Republic of Congo (DRC), Grauer’s gorillas (Gorilla beringei graueri) are continuously threatened through forest encroachment for agricultural expansion, human settlements, new refugee camps, illegal logging, and mining across the country. Moreover, poaching and bushmeat trafficking continuously threaten gorillas’ existence. These drivers increase the proximity of humans and the risk of disease transmission. The emerging and existing zoonotic diseases, including Ebola, are continuously impacting gorillas’ lives. All of these pressures combined are disrupting natural behavior patterns and are leading to the decline in the Grauer’s gorillas’ population. Therefore, this review scrutinizes findings on the anthropogenic pressures on the habitats and survival of Grauer’s gorillas. Also, it is important to engage with people for the shared conservation role and ecotourism to support the conservation of forest biodiversity and Grauer’s gorillas’ habitats, particularly for the Maiko National Park in the DRC.
Eosinophil-Count-Derived Inflammatory Markers and Psoriasis Severity: Exploring the Link
Authors: Tiucă Oana Mirela , Morariu Silviu Horia , Mariean Claudia Raluca , Tiucă Robert Aurelian , Nicolescu Alin Codrut , Cotoi Ovidiu Simion
Published: April 2024

Psoriasis is an immune-mediated disease, with various triggering factors, genetic predisposition, and an altered immune response concurring in the development of this disease. The eosinophil is a cell with an important role in various kinds of inflammatory processes. Scarce data are available regarding the role of the eosinophil in psoriasis. This study aims to address the overall relationship between eosinophil-count-derived inflammatory markers and psoriasis severity. There were 366 patients fulfilling the inclusion criteria included in this retrospective study and they were divided based on the body surface area (BSA) scale in mild and moderate-to-severe psoriasis. White blood cell (WBC), neutrophil, lymphocyte, monocyte, and eosinophil count, along with eosinophil-to-monocyte ratio (EMR) and eosinophil-to-neutrophil ratio (ENR) differed significantly between the two study groups. Eosinophil count, EMR, and ENR negatively correlated with disease severity. ENR is the most reliable eosinophil-count-derived marker in assessing psoriasis severity with an AUC of 0.627 and a cut-off value of 0.03. Eosinophil-count-derived inflammatory markers’ usefulness in appreciating disease severity was assessed for the first time in the literature in this study and proved to be reliable for the eosinophil count, EMR, and ENR.
Performance Assessment of ChatGPT versus Bard in Detecting Alzheimer’s Dementia
Authors: B.T Balamurali , Chen Jer-Ming
Published: April 2024

Large language models (LLMs) find increasing applications in many fields. Here, three LLM chatbots (ChatGPT-3.5, ChatGPT-4, and Bard) are assessed in their current form, as publicly available, for their ability to recognize Alzheimer’s dementia (AD) and Cognitively Normal (CN) individuals using textual input derived from spontaneous speech recordings. A zero-shot learning approach is used at two levels of independent queries, with the second query (chain-of-thought prompting) eliciting more detailed information than the first. Each LLM chatbot’s performance is evaluated on the prediction generated in terms of accuracy, sensitivity, specificity, precision, and F1 score. LLM chatbots generated a three-class outcome (“AD”, “CN”, or “Unsure”). When positively identifying AD, Bard produced the highest true-positives (89% recall) and highest F1 score (71%), but tended to misidentify CN as AD, with high confidence (low “Unsure” rates); for positively identifying CN, GPT-4 resulted in the highest true-negatives at 56% and highest F1 score (62%), adopting a diplomatic stance (moderate “Unsure” rates). Overall, the three LLM chatbots can identify AD vs. CN, surpassing chance-levels, but do not currently satisfy the requirements for clinical application.
Spatial Accuracy and Variability in Dart Throwing in Children with Developmental Coordination Disorder and the Relationship with Ball Skill Items
Authors: Farhat Faiçal , Ammar Achraf , Mezghani Nourhen , Kammoun Mohamed Moncef , Trabelsi Khaled , Jahrami Haitham , Gharbi Adnene , Sallemi Lassad , Rebai Haithem , Moalla Wassim , Smits-Engelsman Bouwien
Published: April 2024

The present study aimed to examine precision and variability in dart throwing performance and the relationships between these outcomes and bouncing, throwing and catching tasks in children with and without DCD. Children between the ages of 8 and 10 years (n = 165) were classified according to results obtained on the Movement Assessment Battery for Children (MABC-2) and divided into three groups: 65 children with severe DCD (s-DCD), 45 with moderate DCD (m-DCD) and 55 typically developing children (TD). All children performed the dart throwing test and the ball skill items of the Performance and Fitness Test (PERF-FIT). The accuracy and variability of dart throwing tasks were significantly different between TD and s-DCD (p < 0.01), and also between m-DCD and s-DCD (p < 0.01). Participants with s-DCD were also found to perform significantly worse on all PERF-FIT ball skill items than m-DCD (p < 0.001), and m-DCD were significantly poorer than TD (p < 0.001). The dart score and coefficient of variation of the long-distance task appear to be significant predictors for the ball skills and explain between 24 to 29% of their variance. In conclusion, poor results in aiming tasks using darts in children with DCD corroborate with the explanation of deficits in predictive control since the tasks require ballistic movements.
Easy Development of Industry 4.0 Remote Labs
Authors: Rejón Carlos , Martin Sergio , Robles-Gómez Antonio
Published: April 2024

Acquiring hands-on skills is nowadays key for engineers in the context of Industry 4.0. However, it is not always possible to achieve this in person. Therefore, it is essential to be able to conduct skill acquisition from a remote location. To support the development of remote labs for experimentation, this work proposes the development of an open Industry 4.0 remote platform that can be easily configured and scaled to develop new remote labs for IoT (Internet of Things), cybersecurity, perception systems, robotics, AI (artificial intelligence), etc. Over time, these capabilities will enable the development of sustainable Industry 4.0 remote labs. These labs will coexist on the same Industry 4.0 platform, as our proposed Industry 4.0 remote platform is capable of connecting multiple heterogeneous types of devices for remote programming. In this way, it is possible to easily design open remote labs for the digital transition to Industry 4.0 in a standardized way, which is the main research goal of our In4Labs project. Several users already conducted a series of IoT experiments on our remote Industry 4.0 platform, providing useful recommendations to be included in future versions of the platform.
Acoustic Design Parameter Change of a Pressurized Combustor Leading to Limit Cycle Oscillations
Authors: Kapucu Mehmet , Kok Jim B. W. , Pozarlik Artur K.
Published: April 2024

When aiming to cut down on the emission of nitric oxides by gas turbine engines, it is advantageous to have them operate at low combustion temperatures. This is achieved by lean premixed combustion. Although lean premixed combustion is a proven and promising technology, it is also very sensitive to thermoacoustic instabilities. These instabilities occur due to a coupling between the unsteady heat release rate of the flame and the acoustic field inside the combustion chamber. In this paper, this coupling is investigated in detail. Two acoustic design parameters of a swirl-stabilized pressurized preheated air (300 °C)/natural gas combustor are varied, and the occurrence of thermoacoustic limit cycle oscillations is explored. The sensitivity of the acoustic field as a function of combustion chamber length (0.9 m to 1.8 m) and reflection coefficient (0.7 and 0.9) at the exit of the combustor is investigated first using a hybrid numerical and analytical approach. ANSYS CFX is used for Unsteady Reynolds Averaged Navier-Stokes (URANS) numerical simulations, and a one-dimensional acoustic network model is used for the analytical investigation. Subsequently, the effects of a change in the reflection coefficient are validated on a pressurized combustor test rig at 125 kW and 1.5 bar. With the change in reflection coefficient, the combustor switched to limit cycle oscillation as predicted, and reached a sound pressure level of 150 dB.
Enhancing the Electrochemical Performance of ZnO-Co3O4 and Zn-Co-O Supercapacitor Electrodes Due to the In Situ Electrochemical Etching Process and the Formation of Co3O4 Nanoparticles
Authors: Abdullin Khabibulla , Gabdullin Maratbek , Kalkozova Zhanar , Kudryashov Vladislav , Mirzaeian Mojtaba , Yelemessov Kassym , Baskanbayeva Dinara , Serikkanov Abay
Published: April 2024

Zinc oxide (ZnO) and materials based on it are often used to create battery-type supercapacitor electrodes and are considered as promising materials for hybrid asymmetric supercapacitors. However, when creating such electrodes, it is necessary to take into account the instability and degradation of zinc oxide in aggressive environments with a non-neutral pH. To the best of our knowledge, studies of the changes in the properties of ZnO-containing electrodes in alkaline electrolytes have not been carried out. In this work, changes in the structure and properties of these electrodes under alkaline treatment were investigated using the example of ZnO-containing composites, which are often used for the manufacturing of supercapacitor electrodes. Supercapacitor electrodes made of two materials containing ZnO were studied: (i) a heterogeneous ZnO-Co3O4 system, and (ii) a hexagonal h-Zn-Co-O solid solution. A comparison was made between the structure and properties of these materials before and after in situ electrochemical oxidation in the process of measuring cyclic voltammetry and galvanostatic charge/discharge. It has been shown that the structure of both nanoparticles of the heterogeneous ZnO-Co3O4 system and the h-Zn-Co-O solid solution changes due to the dissolution of ZnO in the alkaline electrolyte 3.5 M KOH, with the short-term alkaline treatment producing cobalt and zinc hydroxides, and long-term exposure leading to electrochemical cyclic oxidation–reduction, forming cobalt oxide Co3O4. Since the resulting cobalt oxide nanoparticles are immobilized in the electrode structure, a considerable specific capacity of 446 F g−1 or 74.4 mA h g−1 is achieved at a mass loading of 0.0105 g. The fabricated hybrid capacitor showed a good electrochemical performance, with a series resistance of 0.2 Ohm and a capacitance retention of 87% after 10,000 cycles.
Temporal Complementarity Analysis of Wind and Solar Power Potential for Distributed Hybrid Electric Generation in Chile
Authors: Muñoz-Pincheira José Luis , Salazar Lautaro , Sanhueza Felipe , Lüer-Villagra Armin
Published: April 2024

We evaluate the temporal complementarity in daily averages between wind and solar power potential in Chile using Spearman’s correlation coefficient. We used hourly wind speed and solar radiation data for 176 geographic points from 2004 to 2016. The results allow us to identify four zones: Zone A1 on the coast and in the valleys in the north of Chile between latitudes 18° S and 36° S, with moderate positive correlation; Zone A2 in the north Andes between latitudes 25° S and 33° S, with weak negative correlation; Zone B in the center-south part of the country between latitudes 36° S and 51° S with moderate negative correlation; and Zone C in the south, between latitudes 51° S and 55° S with null or weak positive correlation. On the one hand, the interannual analysis shows that Zone A1 keeps uniform correlation values with negative asymmetry, i.e., higher correlation values. On the other hand, there is positive asymmetry in most of the years in Zone A2, i.e., lower (or negative) values of correlation. Zone B shows an interannual oscillation of the median correlation, while Zone C shows a larger dispersion in the interannual results. Significance analysis shows that 163 out of the 176 points are statistically significant, while Zones A1, A2, and B have significant correlations, with Zone C being marginally significant. The results obtained are relevant information for further studies on the location of hybrid generation facilities. We expect our methodology to be instrumental in Chile’s energetic transition to a 100% renewable generation matrix.
Electrodynamic Forces in Main Three-Phase Busbar System of Low-Voltage Switchgear—FEA Simulation
Authors: Łapczyński Sebastian , Szulborski Michał , Kolimas Łukasz , Sul Przemysław , Owsiński Maciej , Berowski Przemysław , Żelaziński Tomasz , Lange Andrzej
Published: April 2024

This paper concerns the effects of electrodynamic forces that act on current paths that are part of high-grade industrial distribution switchgear. This work is composed of experimental and simulation sections. In the experimental section, the short-circuit tests are presented and the occurrence of electrodynamic forces are shown in a visible way. The formation of electrodynamic forces in the current circuits of electrical energy distribution systems is related to the flow of high currents, but mostly it is related to short-circuit currents. In order to highlight these phenomena, the detailed specification of the parameters during tests is displayed. In the simulation section, the physical phenomenon of electrodynamic forces is being captured by employing a detailed real-scale model of switchgear and current paths. Therefore, the authors proposed employment of the FEM (finite element method) in order to obtain values of electrodynamic forces acting on the current paths by executing the detailed 3D coupled simulation. The analysis of the results and aftermath effects of their interactions provided interesting conclusions that concerned the operation of such power distribution layouts in critical short-circuit conditions.
Assessing Energy Potential and Chemical Composition of Food Waste Thermodynamic Conversion Products: A Literature Review
Authors: Škorjanc Andreja , Goričanec Darko , Urbancl Danijela
Published: April 2024

This study examines the considerable volume of food waste generated annually in Slovenia, which amounted to over 143,000 tons in 2020. The analysis shows that 40% of food waste consists of edible parts, highlighting the potential for reduction through increased consumer awareness and attitudes towards food consumption. The study shows that the consumption phase contributes the most to waste food (46%), followed by primary production (25%) and processing/manufacture (24%). The study addresses various thermodynamic processes, in particular, thermal conversion methods, such as torrefaction pyrolysis and hydrothermal carbonization, which optimize energy potential by reducing the atomic ratio (H/C) and (O/C), thereby increasing calorific value and facilitating the production of solid fuels. The main results show the effectiveness of torrefaction, pyrolysis and hydrothermal carbonization (HTC) in increasing the energy potential of food waste.
Non-Iterative Coordinated Optimisation of Power–Traffic Networks Based on Equivalent Projection
Authors: Dai Wei , Zeng Zhihong , Wang Cheng , Zhang Zhijie , Gao Yang , Xu Jun
Published: April 2024

The exchange of sensitive information between power distribution networks (PDNs) and urban transport networks (UTNs) presents a difficulty in ensuring privacy protection. This research proposes a new collaborative operation method for a coupled system. The scheme takes into account the schedulable capacity of electric vehicle charging stations (EVCSs) and locational marginal prices (LMPs) to handle the difficulty at hand. The EVCS hosting capacity model is built and expressed as the feasible area of charging power, based on AC power flow. This model is then used to offer information on the real schedulable capacity. By incorporating the charging loads into the coupling nodes between PDNs and UTNs, the issue of coordinated operation is separated and becomes equal to the optimal problem involving charging loads. Based on this premise, the most efficient operational cost of PDNs is transformed into a comparable representation of cost information in PDNs. This representation incorporates LMP information that guides charging decisions in UTNs. The suggested collaborative scheduling methodology in UTNs utilises the collected projection information from the static traffic assignment (STA) to ensure data privacy protection and achieve non-iterative calculation. Numerical experiments are conducted to illustrate that the proposed method, which uses a smaller amount of data, achieves the same level of optimality as the coordinated optimisation.
Biofabrication of Silver Nanoparticles by Azadirachta indica Rhizosphere Bacteria with Enhanced Antibacterial Properties
Authors: Kattali Mashhoor , Mampett Keerthana P. , Kodoor Hamna Fathima , Ponnenkunnathu Sreejesh Govindankutty , Soman Somy , Kar Mahapatra Debarshi , Joseph Tomy Muringayil , Haponiuk Józef , Thomas Sabu
Published: April 2024

Microorganisms (MOs) are prominent in ecological functioning and balance. The rhizosphere is considered one of the most diverse ecosystems on Earth and serves as a breeding spot for many MOs. Rhizosphere microbial diversity changes according to plant species, genotype, and the nature of the soil. The current study reports the possible use of bacteria isolated from the rhizosphere of Azadirachta indica for synthesizing silver nanoparticles (AgNPs). The physicochemical characterization and antibacterial activity of these green synthesized AgNPs are also reported. The gene (16S rRNA) sequence of bacteria isolated from the rhizosphere showed a maximum similarity of 99.25% with Bacillus subtilis. After incubation, the colorless reaction mixture transformed to brown, which indicates the formation of AgNPs, and UV-vis spectral analysis also confirmed the biosynthesis of AgNPs. Compared to lower temperatures, the efficiency of AgNP synthesis was high at the higher temperature. The scanning electron microscope image demonstrated spherical-shaped AgNPs with sizes ranging from 18 to 21 nm. Energy-dispersive X-ray analysis established the elemental analysis of synthesized AgNPs. The synthesized AgNPs showed strong bactericidal properties against pathogenic bacteria Klebsiella pneumonia, Pseudomonas aeruginosa, Escherichia coli, and methicillin-resistant Staphylococcus aureus.
Computational Fluid Dynamics Prediction of External Thermal Loads on Film-Cooled Gas Turbine Vanes: A Validation of Reynolds-Averaged Navier–Stokes Transition Models and Scale-Resolving Simulations for the VKI LS-94 Test Case
Authors: Sandrin Simone , Mazzei Lorenzo , Da Soghe Riccardo , Fontaneto Fabrizio
Published: April 2024

Given the increasing role of computational fluid dynamics (CFD) simulations in the aerothermal design of gas turbine vanes and blades, their rigorous validation is becoming more and more important. This article exploits an experimental database obtained by the von Karman Institute (VKI) for Fluid Dynamics for the LS-94 test case. This represents a film-cooled transonic turbine vane, investigated in a five-vane linear cascade configuration under engine-like conditions in terms of the Reynolds number and Mach number. The experimental characterization included inlet freestream turbulence measured with hot-wire anemometry, aerodynamic performance assessed with a three-hole pressure probe in the downstream section, and vane convective heat transfer coefficient distribution determined with thin-film thermometers. The test matrix included cases without any film-cooling injection, pressure-side injection, and suction-side injection. The CFD simulations were carried out in Ansys Fluent, considering the impact of mesh sizing and steady-state Reynolds-Averaged Navier-Stokes (RANS) transition modelling, as well as more accurate transient scale-resolving simulations. This work provides insight into the advantages and drawbacks of such approaches for gas turbine hot-gas path designers.
Stability and Bifurcation Control for a Generalized Delayed Fractional Food Chain Model
Authors: Li Qing , Liu Hongxia , Zhao Wencai , Meng Xinzhu
Published: April 2024

In this paper, a generalized fractional three-species food chain model with delay is investigated. First, the existence of a positive equilibrium is discussed, and the sufficient conditions for global asymptotic stability are given. Second, through selecting the delay as the bifurcation parameter, we obtain the sufficient condition for this non-control system to generate Hopf bifurcation. Then, a nonlinear delayed feedback controller is skillfully applied to govern the system’s Hopf bifurcation. The results indicate that adjusting the control intensity or the control target’s age can effectively govern the bifurcation dynamics behavior of this system. Last, through application examples and numerical simulations, we confirm the validity and feasibility of the theoretical results, and find that the control strategy is also applicable to eco-epidemiological systems.
Heritability of Gene Expression Measured from Peripheral Blood in Older Adults
Authors: Kanchibhotla Sri C. , Mather Karen A. , Armstrong Nicola J. , Ciobanu Liliana G. , Baune Bernhard T. , Catts Vibeke S. , Schofield Peter R. , Trollor Julian N. , Ames David , Sachdev Perminder S. , Thalamuthu Anbupalam
Published: April 2024

The contributions of genetic variation and the environment to gene expression may change across the lifespan. However, few studies have investigated the heritability of blood gene expression in older adults. The current study therefore aimed to investigate this question in a community sample of older adults. A total of 246 adults (71 MZ and 52 DZ twins, 69.91% females; mean age—75.79 ± 5.44) were studied. Peripheral blood gene expression was assessed using Illumina microarrays. A heritability analysis was performed using structural equation modelling. There were 5269 probes (19.9%) from 4603 unique genes (23.9%) (total 26,537 probes from 19,256 genes) that were significantly heritable (mean h2 = 0.40). A pathway analysis of the top 10% of significant genes showed enrichment for the immune response and ageing-associated genes. In a comparison with two other gene expression twin heritability studies using adults from across the lifespan, there were 38 out of 9479 overlapping genes that were significantly heritable. In conclusion, our study found ~24% of the available genes for analysis were heritable in older adults, with only a small number common across studies that used samples from across adulthood, indicating the importance of examining gene expression in older age groups.
Association of CYP3A4-392A/G, CYP3A5-6986A/G, and ABCB1-3435C/T Polymorphisms with Tacrolimus Dose, Serum Concentration, and Biochemical Parameters in Mexican Patients with Kidney Transplant
Authors: Alatorre-Moreno Edith Viridiana , Saldaña-Cruz Ana Miriam , Pérez-Guerrero Edsaúl Emilio , Morán-Moguel María Cristina , Contreras-Haro Betsabé , López-de La Mora David Alejandro , Dávalos-Rodríguez Ingrid Patricia , Marín-Medina Alejandro , Rivera-Cameras Alicia , Balderas-Peña Luz-Ma Adriana , Gómez-Ramos José Juan , Cortés-Sanabria Laura , Salazar-Páramo Mario
Published: April 2024

Tacrolimus (TAC) is an immunosuppressant drug that prevents organ rejection after transplantation. This drug is transported from cells via P-glycoprotein (ABCB1) and is a metabolic substrate for cytochrome P450 (CYP) 3A enzymes, particularly CYP3A4 and CYP3A5. Several single-nucleotide polymorphisms (SNPs) have been identified in the genes encoding CYP3A4, CYP3A5, and ABCB1, including CYP3A4-392A/G (rs2740574), CYP3A5 6986A/G (rs776746), and ABCB1 3435C/T (rs1045642). This study aims to evaluate the association among CYP3A4-392A/G, CYP3A5-6986A/G, and ABCB1-3435C/T polymorphisms and TAC, serum concentration, and biochemical parameters that may affect TAC pharmacokinetics in Mexican kidney transplant (KT) patients. Methods: Forty-six kidney transplant recipients (KTR) receiving immunosuppressive treatment with TAC in different combinations were included. CYP3A4, CYP3A5, and ABCB1 gene polymorphisms were genotyped using qPCR TaqMan. Serum TAC concentration (as measured) and intervening variables were assessed. Logistic regression analyses were performed at baseline and after one month to assess the extent of the association between the polymorphisms, intervening variables, and TAC concentration. Results: The GG genotype of CYP3A5-6986 A/G polymorphism is associated with TAC pharmacokinetic variability OR 4.35 (95%CI: 1.13–21.9; p = 0.0458) at one month of evolution; in multivariate logistic regression, CYP3A5-6986GG genotype OR 9.32 (95%CI: 1.54–93.08; p = 0.028) and the use of medications or drugs that increase serum TAC concentration OR 9.52 (95%CI: 1.79–88.23; p = 0.018) were strongly associated with TAC pharmacokinetic variability. Conclusion: The findings of this study of the Mexican population showed that CYP3A5-6986 A/G GG genotype is associated with a four-fold increase in the likelihood of encountering a TAC concentration of more than 15 ng/dL. The co-occurrence of the CYP3A5-6986GG genotype and the use of drugs that increase TAC concentration correlates with a nine-fold increased risk of experiencing a TAC at a level above 15 ng/mL. Therefore, these patients have an increased susceptibility to TAC-associated toxicity.
Exploring Convolutional Neural Networks for the Thermal Image Classification of Volcanic Activity
Authors: Nunnari Giuseppe , Calvari Sonia
Published: April 2024

This paper addresses the classification of images depicting the eruptive activity of Mount Etna, captured by a network of ground-based thermal cameras. The proposed approach utilizes Convolutional Neural Networks (CNNs), focusing on pretrained models. Eight popular pretrained neural networks underwent systematic evaluation, revealing their effectiveness in addressing the classification problem. The experimental results demonstrated that, following a retraining phase with a limited dataset, specific networks such as VGG-16 and AlexNet, achieved an impressive total accuracy of approximately 90%. Notably, VGG-16 and AlexNet emerged as practical choices, exhibiting individual class accuracies exceeding 90%. The case study emphasized the pivotal role of transfer learning, as attempts to solve the classification problem without pretrained networks resulted in unsatisfactory outcomes.
Physiological Variability during Prehospital Stroke Care: Which Monitoring and Interventions Are Used?
Authors: Alshehri Abdulaziz , Ince Jonathan , Panerai Ronney B. , Divall Pip , Robinson Thompson G. , Minhas Jatinder S.
Published: April 2024

Prehospital care is a fundamental component of stroke care that predominantly focuses on shortening the time between diagnosis and reaching definitive stroke management. With growing evidence of the physiological parameters affecting long-term patient outcomes, prehospital clinicians need to consider the balance between rapid transfer and increased physiological-parameter monitoring and intervention. This systematic review explores the existing literature on prehospital physiological monitoring and intervention to modify these parameters in stroke patients. The systematic review was registered on PROSPERO (CRD42022308991) and conducted across four databases with citation cascading. Based on the identified inclusion and exclusion criteria, 19 studies were retained for this review. The studies were classified into two themes: physiological-monitoring intervention and pharmacological-therapy intervention. A total of 14 included studies explored prehospital physiological monitoring. Elevated blood pressure was associated with increased hematoma volume in intracerebral hemorrhage and, in some reports, with increased rates of early neurological deterioration and prehospital neurological deterioration. A reduction in prehospital heart rate variability was associated with unfavorable clinical outcomes. Further, five of the included records investigated the delivery of pharmacological therapy in the prehospital environment for patients presenting with acute stroke. BP-lowering interventions were successfully demonstrated through three trials; however, evidence of their benefit to clinical outcomes is limited. Two studies investigating the use of oxygen and magnesium sulfate as neuroprotective agents did not demonstrate an improvement in patient’s outcomes. This systematic review highlights the absence of continuous physiological parameter monitoring, investigates fundamental physiological parameters, and provides recommendations for future work, with the aim of improving stroke patient outcomes.
Association between Changes in Daily Life Due to COVID-19 and Depressive Symptoms in South Korea
Authors: Son Ha-Eun , Hong Young-Seoub , Son Hyunjin
Published: April 2024

We aimed to examine changes in daily life due to coronavirus disease 2019 (COVID-19) among younger (≤64 years) and older (≥65 years) individuals and to analyze their association with depressive symptoms. Raw data from the 2020 Korean Community Health Survey were used to analyze 228,485 individuals. Changes in daily life due to COVID-19 were measured using a questionnaire that evaluated changes in physical activity, sleep duration, instant food intake, and drinking and smoking status. Depressive symptoms were assessed using the Patient Health Questionnaire 9 scale, and logistic regression analysis was performed to explore the association between the two variables. This study confirmed a significant association between the two variables and found that the intake of instant food showed the largest difference in odds ratios between the younger (OR: 1.851; 95% CI: 1.720–1.992) and older groups (OR: 1.239; 95% CI: 1.060–1.447). A major finding of this study is that the analysis of the association between the two variables revealed a stronger correlation in more variables in the younger population compared to the older population. To address COVID-19-related depression and prepare for potential mental health crises, countries should expand response measures.