bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure from Investigation of the Prevalence and Number of Aberrant Crypt Foci Associated with Human Colorectal Neoplasm
Authors: Sakai Eiji , Takahashi Hirokazu , Kato Shingo , Uchiyama Takashi , Hosono Kunihiro , Endo Hiroki , Maeda Shin , Yoneda Masato , Taguri Masataka , Nakajima Atsushi
Published: March 2023

PDF file - 290K
Supplementary Figures 1-3 from Chromosome 3p12.3-p14.2 and 3q26.2-q26.32 Are Genomic Markers for Prognosis of Advanced Nasopharyngeal Carcinoma
Authors: Sheu Jim Jinn-Chyuan , Lee Chia-Huei , Ko Jenq-Yuh , Tsao George S.W. , Wu Chung-Chun , Fang Chih-Yeu , Tsai Fuu-Jen , Hua Chun-Hung , Chen Chi-Long , Chen Jen-Yang
Published: March 2023

Supplementary Figures 1-3 from Chromosome 3p12.3-p14.2 and 3q26.2-q26.32 Are Genomic Markers for Prognosis of Advanced Nasopharyngeal Carcinoma
Data Supplement from Sun Exposure and Melanoma Survival: A GEM Study
Authors: Berwick Marianne , Reiner Anne S. , Paine Susan , Armstrong Bruce K. , Kricker Anne , Goumas Chris , Cust Anne E. , Thomas Nancy E. , Groben Pamela A. , From Lynn , Busam Klaus , Orlow Irene , Marrett Loraine D. , Gallagher Richard P. , Gruber Stephen B. , Anton-Culver Hoda , Rosso Stefano , Zanetti Roberto , Kanetsky Peter A. , Dwyer Terry , Venn Alison , Lee-Taylor Julia , Begg Colin B.
Published: March 2023

Supplementary Table S2. Early life sun exposure and its association with melanoma survival, adjusting for Breslow thickness.
Supplementary Table 2 from Smoking at Diagnosis Is an Independent Prognostic Factor for Cancer-Specific Survival in Head and Neck Cancer: Findings from a Large, Population-Based Study
Authors: Sharp Linda , McDevitt Joseph , Carsin Anne-Elie , Brown Christopher , Comber Harry
Published: March 2023

Supplementary table 2: post-hoc analysis of associations between smoking status and survival by treatment(s) received
Supplementary Table 2 from Genetically Lowered Microsomal Epoxide Hydrolase Activity and Tobacco-Related Cancer in 47,000 Individuals
Authors: Lee Julie , Dahl Morten , Nordestgaard Børge G.
Published: March 2023

Supplementary Table 2 from Genetically Lowered Microsomal Epoxide Hydrolase Activity and Tobacco-Related Cancer in 47,000 Individuals
Supplementary Figure 1 from A Genome-Wide Survey over the ChIP-On-Chip Identified Androgen Receptor-Binding Genomic Regions Identifies a Novel Prostate Cancer Susceptibility Locus at 12q13.13
Authors: Feng Junjie , Sun Jielin , Kim Seong-Tae , Lu Yizhen , Wang Zhong , Zhang Zheng , Gronberg Henrik , Isaacs William B. , Zheng S. Lilly , Xu Jianfeng
Published: March 2023

PDF file - 8.61MB
Supplementary Table 1 from Effect of Long-term Storage in TRIzol on Microarray-Based Gene Expression Profiling
Authors: Ma Wencai , Wang Michael , Wang Zhi-Qiang , Sun Luhong , Graber David , Matthews Jairo , Champlin Richard , Yi Qing , Orlowski Robert Z. , Kwak Larry W. , Weber Donna M. , Thomas Sheeba K. , Shah Jatin , Kornblau Steven , Davis Richard E.
Published: March 2023

Supplementary Table 1 from Effect of Long-term Storage in TRIzol on Microarray-Based Gene Expression Profiling
Supplementary Information from The Effects of Test Preference, Test Access, and Navigation on Colorectal Cancer Screening
Authors: Daskalakis Constantine , Vernon Sally W. , Sifri Randa , DiCarlo Melissa , Cocroft James , Sendecki Jocelyn Andrel , Myers Ronald E.
Published: March 2023

PDF file - 62KB, Supplementary information regarding the modeling and estimation of access and navigation effects.
Supplementary Table 1 from A Candidate Molecular Biomarker Panel for the Detection of Bladder Cancer
Authors: Urquidi Virginia , Goodison Steve , Cai Yunpeng , Sun Yijun , Rosser Charles J.
Published: March 2023

PDF file - 44K, Transcriptional profiling of urothelia from 52 bladder cancer patiens and 40 patients with no evidence of bladder cancer. Differentiallyexpressedgenes (p value ≤0.001 ) 223816_
Supplementary Document B from A Candidate Molecular Biomarker Panel for the Detection of Bladder Cancer
Authors: Urquidi Virginia , Goodison Steve , Cai Yunpeng , Sun Yijun , Rosser Charles J.
Published: March 2023

PDF file - 79K, Quantitative PCR analysis
Supplementary Figure 2 from A Systematic Review of p53 as a Prognostic Factor of Survival in Squamous Cell Carcinoma of the Four Main Anatomical Subsites of the Head and Neck
Authors: Tandon Sankalap , Tudur-Smith Catrin , Riley Richard D. , Boyd Mark T. , Jones Terence M.
Published: March 2023

Supplementary Figure 2 from A Systematic Review of p53 as a Prognostic Factor of Survival in Squamous Cell Carcinoma of the Four Main Anatomical Subsites of the Head and Neck
Supplementary Figure 4 from A Variable Age of Onset Segregation Model for Linkage Analysis, with Correction for Ascertainment, Applied to Glioma
Authors: Sun Xiangqing , Vengoechea Jaime , Elston Robert , Chen Yanwen , Amos Christopher I. , Armstrong Georgina , Bernstein Jonine L. , Claus Elizabeth , Davis Faith , Houlston Richard S. , Il'yasova Dora , Jenkins Robert B. , Johansen Christoffer , Lai Rose , Lau Ching C. , Liu Yanhong , McCarthy Bridget J. , Olson Sara H. , Sadetzki Siegal , Schildkraut Joellen , Shete Sanjay , Yu Robert , Vick Nicholas A. , Merrell Ryan , Wrensch Margaret , Yang Ping , Melin Beatrice , Bondy Melissa L. , Barnholtz-Sloan Jill S.
Published: March 2023

PDF file, 89K, L-scores for three prior settings, after discarding the beginning 5K iterations
Supplementary Tables 1-3 from A Common Prostate Cancer Risk Variant 5′ of Microseminoprotein-β (MSMB) Is a Strong Predictor of Circulating β-Microseminoprotein (MSP) Levels in Multiple Populations
Authors: Waters Kevin M. , Stram Daniel O. , Le Marchand Loic , Klein Robert J. , Valtonen-André Camilla , Peltola Mari T. , Kolonel Laurence N. , Henderson Brian E. , Lilja Hans , Haiman Christopher A.
Published: March 2023

Supplementary Tables 1-3 from A Common Prostate Cancer Risk Variant 5′ of Microseminoprotein-β (MSMB) Is a Strong Predictor of Circulating β-Microseminoprotein (MSP) Levels in Multiple Populations
Supplementary Figure S1 from Shorter Leukocyte Telomere Length Is Independently Associated with Poor Survival in Patients with Bladder Cancer
Authors: Russo Alessia , Modica Federica , Guarrera Simonetta , Fiorito Giovanni , Pardini Barbara , Viberti Clara , Allione Alessandra , Critelli Rossana , Bosio Andrea , Casetta Giovanni , Cucchiarale Giuseppina , Destefanis Paolo , Gontero Paolo , Rolle Luigi , Zitella Andrea , Fontana Dario , Frea Bruno , Vineis Paolo , Sacerdote Carlotta , Matullo Giuseppe
Published: March 2023

Supplementary Figure S1. Kaplan-Meier OS curves of bladder cancer patients stratified for TL quartiles. OS, overall survival; TL, telomere length.
Supplementary figure 6 from The Effect of Exercise Training on Mediators of Inflammation in Breast Cancer Survivors: A Systematic Review with Meta-analysis
Authors: Meneses-Echávez Jose F. , Correa-Bautista Jorge E. , González-Jiménez Emilio , Schmidt Río-Valle Jacqueline , Elkins Mark R. , Lobelo Felipe , Ramírez-Vélez Robinson
Published: March 2023

Funnel plot for the assessment of publication bias
Legends for Supplementary figures from The Effect of Exercise Training on Mediators of Inflammation in Breast Cancer Survivors: A Systematic Review with Meta-analysis
Authors: Meneses-Echávez Jose F. , Correa-Bautista Jorge E. , González-Jiménez Emilio , Schmidt Río-Valle Jacqueline , Elkins Mark R. , Lobelo Felipe , Ramírez-Vélez Robinson
Published: March 2023

Legends for the figures included in the manuscript
Supplemental Tables 1-3 from Explaining the Obesity Paradox: The Association between Body Composition and Colorectal Cancer Survival (C-SCANS Study)
Authors: Caan Bette J. , Meyerhardt Jeffrey A. , Kroenke Candyce H. , Alexeeff Stacey , Xiao Jingjie , Weltzien Erin , Feliciano Elizabeth Cespedes , Castillo Adrienne L. , Quesenberry Charles P. , Kwan Marilyn L. , Prado Carla M.
Published: March 2023

Supplemental Tables 1-3
Supplementary Figure S2 from Improving the Quality of Biomarker Discovery Research: The Right Samples and Enough of Them
Authors: Pepe Margaret S. , Li Christopher I. , Feng Ziding
Published: March 2023

Supplementary Figure S2. ROC curves for two biomarkers, A (red) and B (blue).
Supplementary Notes from Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci
Authors: Amin Al Olama Ali , Benlloch Sara , Antoniou Antonis C. , Giles Graham G. , Severi Gianluca , Neal David E. , Hamdy Freddie C. , Donovan Jenny L. , Muir Kenneth , Schleutker Johanna , Henderson Brian E. , Haiman Christopher A. , Schumacher Fredrick R. , Pashayan Nora , Pharoah Paul D.P. , Ostrander Elaine A. , Stanford Janet L. , Batra Jyotsna , Clements Judith A. , Chambers Suzanne K. , Weischer Maren , Nordestgaard Børge G. , Ingles Sue A. , Sorensen Karina D. , Orntoft Torben F. , Park Jong Y. , Cybulski Cezary , Maier Christiane , Doerk Thilo , Dickinson Joanne L. , Cannon-Albright Lisa , Brenner Hermann , Rebbeck Timothy R. , Zeigler-Johnson Charnita , Habuchi Tomonori , Thibodeau Stephen N. , Cooney Kathleen A. , Chappuis Pierre O. , Hutter Pierre , Kaneva Radka P. , Foulkes William D. , Zeegers Maurice P. , Lu Yong-Jie , Zhang Hong-Wei , Stephenson Robert , Cox Angela , Southey Melissa C. , Spurdle Amanda B. , FitzGerald Liesel , Leongamornlert Daniel , Saunders Edward , Tymrakiewicz Malgorzata , Guy Michelle , Dadaev Tokhir , Little Sarah J. , Govindasami Koveela , Sawyer Emma , Wilkinson Rosemary , Herkommer Kathleen , Hopper John L. , Lophatonanon Aritaya , Rinckleb Antje E. , Kote-Jarai Zsofia , Eeles Rosalind A. , Easton Douglas F.
Published: March 2023

Supplementary Notes. This document includes description of studies that they have been used for the analysis.
Supplemental Tables 1-7 and Methods from Association between Regular Aspirin Use and Circulating Markers of Inflammation: A Study within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
Authors: Lang Kuhs Krystle A. , Hildesheim Allan , Trabert Britton , Kemp Troy J. , Purdue Mark P. , Wentzensen Nicolas , Katki Hormuzd A. , Pinto Ligia A. , Loftfield Erikka , Safaeian Mahboobeh , Chaturvedi Anil K. , Shiels Meredith S.
Published: March 2023

Supplemental Tables 1-7 and Methods. Details on development of sampling weights and their use in analysis. Supplemental Table 1. Description of three case-control studies nested within PLCO. Supplemental Table 2. Multiplex immune panel markers measured in the PLCO Cancer Screening Study. Supplemental Table 3: Percent detection and median levels for each inflammatory marker by original study. Supplemental Table 4: Participant characteristics for i) the 1,819 individuals with inflammatory marker data, ii) the weighted population and iii) those in the PLCO screening arm that met the study eligibility criteria. Supplemental Table 5: Associations between regular aspirin use and circulating inflammatory markers2, restricted to individuals without a history of chronic heart disease, stroke or arthritis. Supplemental Table 6: Associations between regular aspirin use and circulating inflammatory markers2, by study. Supplemental Table 7: Associations between regular aspirin use and circulating inflammatory markers.
Supplementary Figure 3 from Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci
Authors: Amin Al Olama Ali , Benlloch Sara , Antoniou Antonis C. , Giles Graham G. , Severi Gianluca , Neal David E. , Hamdy Freddie C. , Donovan Jenny L. , Muir Kenneth , Schleutker Johanna , Henderson Brian E. , Haiman Christopher A. , Schumacher Fredrick R. , Pashayan Nora , Pharoah Paul D.P. , Ostrander Elaine A. , Stanford Janet L. , Batra Jyotsna , Clements Judith A. , Chambers Suzanne K. , Weischer Maren , Nordestgaard Børge G. , Ingles Sue A. , Sorensen Karina D. , Orntoft Torben F. , Park Jong Y. , Cybulski Cezary , Maier Christiane , Doerk Thilo , Dickinson Joanne L. , Cannon-Albright Lisa , Brenner Hermann , Rebbeck Timothy R. , Zeigler-Johnson Charnita , Habuchi Tomonori , Thibodeau Stephen N. , Cooney Kathleen A. , Chappuis Pierre O. , Hutter Pierre , Kaneva Radka P. , Foulkes William D. , Zeegers Maurice P. , Lu Yong-Jie , Zhang Hong-Wei , Stephenson Robert , Cox Angela , Southey Melissa C. , Spurdle Amanda B. , FitzGerald Liesel , Leongamornlert Daniel , Saunders Edward , Tymrakiewicz Malgorzata , Guy Michelle , Dadaev Tokhir , Little Sarah J. , Govindasami Koveela , Sawyer Emma , Wilkinson Rosemary , Herkommer Kathleen , Hopper John L. , Lophatonanon Aritaya , Rinckleb Antje E. , Kote-Jarai Zsofia , Eeles Rosalind A. , Easton Douglas F.
Published: March 2023

Supplementary Figure 3. Absolute Risk (A model with only family history of prostate cancer)
Supplementary Tables from Prevalence and Penetrance of Major Genes and Polygenes for Colorectal Cancer
Authors: Win Aung Ko , Jenkins Mark A. , Dowty James G. , Antoniou Antonis C. , Lee Andrew , Giles Graham G. , Buchanan Daniel D. , Clendenning Mark , Rosty Christophe , Ahnen Dennis J. , Thibodeau Stephen N. , Casey Graham , Gallinger Steven , Le Marchand Loïc , Haile Robert W. , Potter John D. , Zheng Yingye , Lindor Noralane M. , Newcomb Polly A. , Hopper John L. , MacInnis Robert J.
Published: March 2023

Supplementary Table 1: Results of segregation analyses incorporating mismatch repair gene and MUTYH mutation carrier status. Supplementary Table 2. Estimated population carrier frequency of a mismatch repair gene or MUTYH mutation from previous studies and current study.
Supplementary Tables 1 - 2 from Polymorphisms in Inflammation Pathway Genes and Endometrial Cancer Risk
Authors: Delahanty Ryan J. , Xiang Yong-Bing , Spurdle Amanda , Beeghly-Fadiel Alicia , Long Jirong , Thompson Deborah , Tomlinson Ian , Yu Herbert , Lambrechts Diether , Dörk Thilo , Goodman Marc T. , Zheng Ying , Salvesen Helga B. , Bao Ping-Ping , Amant Frederic , Beckmann Matthias W. , Coenegrachts Lieve , Coosemans An , Dubrowinskaja Natalia , Dunning Alison , Runnebaum Ingo B. , Easton Douglas , Ekici Arif B. , Fasching Peter A. , Halle Mari K. , Hein Alexander , Howarth Kimberly , Gorman Maggie , Kaydarova Dylyara , Krakstad Camilla , Lose Felicity , Lu Lingeng , Lurie Galina , O'Mara Tracy , Matsuno Rayna K. , Pharoah Paul , Risch Harvey , Corssen Madeleine , Trovik Jone , Turmanov Nurzhan , Wen Wanqing , Lu Wei , Cai Qiuyin , Zheng Wei , Shu Xiao-Ou
Published: March 2023

PDF file - 70K, Candidate inflammation genes selected for stage 1 study, Annotation of potentially functional SNPs in linkage disequilibrium (r2 > 0.2) with rs352038 (CXCL3) or rs3918249 (MMP9)
Supplementary information from Prognostic Impact of Cigarette Smoking on the Survival of Patients with Established Nasopharyngeal Carcinoma
Authors: OuYang Pu-Yun , Su Zhen , Mao Yan-Ping , Liang Xue-Xia , Liu Qing , Deng Wuguo , Xie Fang-Yun
Published: March 2023

The process and result of exploring the two continuous variables - AGE and PACK-YEARS - using restricted cubic splines nested within Cox models by RCS-macro of SAS (SAS Institute, Cary, NC).
Supplementary Figure 2 from Aberrant Vimentin Methylation Is Characteristic of Upper Gastrointestinal Pathologies
Authors: Moinova Helen , Leidner Rom S. , Ravi Lakshmeswari , Lutterbaugh James , Barnholtz-Sloan Jill S. , Chen Yanwen , Chak Amitabh , Markowitz Sanford D. , Willis Joseph E.
Published: March 2023

PDF file - 43K
Figure S1 from The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies
Authors: Zhang Xia , Zhao Qian , Zhu Wei , Liu Tao , Xie Shao-Hua , Zhong Li-Xin , Cai Yuan-Yuan , Li Xiao-Na , Liang Mei , Chen Wen , Hu Qian-Sheng , Zhang Bo
Published: March 2023

Figure S1 shows Egger's test for publication bias.
Supplementary Table 1 from Self-sample HPV Tests As an Intervention for Nonattendees of Cervical Cancer Screening in Finland: a Randomized Trial
Authors: Virtanen Anni , Nieminen Pekka , Luostarinen Tapio , Anttila Ahti
Published: March 2023

PDF file - 46K, HPV-test positivity by invitational mode, mother tongue and age among screening participants in study years. Table of HPV-test positivity by invitational mode, mother tongue and age among screening participants in study years.
Supplementary Figure 3 from Putative Linkage Signals Identified for Breast Cancer in African American Families
Authors: Ochs-Balcom Heather M. , Sun Xiangqing , Chen Yanwen , Barnholtz-Sloan Jill , Erwin Deborah O. , Jandorf Lina , Sucheston-Campbell Lara , Elston Robert C.
Published: March 2023

Supplementary Figure 3. Genome-wide model-free multi-point linkage by SIBPAL, P-values based on up to 1,000,000 permutations (Haseman-Elston regression), with DOB (sibpair sum and difference) and global ancestry (sibpair difference) as covariates.
Supplemental Figure Legend from Putative Linkage Signals Identified for Breast Cancer in African American Families
Authors: Ochs-Balcom Heather M. , Sun Xiangqing , Chen Yanwen , Barnholtz-Sloan Jill , Erwin Deborah O. , Jandorf Lina , Sucheston-Campbell Lara , Elston Robert C.
Published: March 2023

Supplemental Figure Legend
Supplemental Figures 1-2 from Genome-wide Gene–Asbestos Exposure Interaction Association Study Identifies a Common Susceptibility Variant on 22q13.31 Associated with Lung Cancer Risk
Authors: Liu Chen-yu , Stücker Isabelle , Chen Chu , Goodman Gary , McHugh Michelle K. , D'Amelio Anthony M. , Etzel Carol J. , Li Su , Lin Xihong , Christiani David C.
Published: March 2023

Supplemental Figures 1-2 including: (1) Supplementary Figure 1. Genome-wide genetic association and lung cancer risk in discovery stage; (2) Supplementary Figure 2. Genome-wide gene-asbestos exposure interactions and lung cancer risk in discovery stage.
Supplementary Table 1 from Cancer in Africa 2012
Authors: Parkin D. Maxwell , Bray Freddie , Ferlay Jacques , Jemal Ahmedin
Published: March 2023

PDF file - 106K, Sources and methods used to compile African national incidence estimates in GLOBOCAN 2012.
Supplementary Table 3 from HOXB13 G84E Mutation in Finland: Population-Based Analysis of Prostate, Breast, and Colorectal Cancer Risk
Authors: Laitinen Virpi H. , Wahlfors Tiina , Saaristo Leena , Rantapero Tommi , Pelttari Liisa M. , Kilpivaara Outi , Laasanen Satu-Leena , Kallioniemi Anne , Nevanlinna Heli , Aaltonen Lauri , Vessella Robert L. , Auvinen Anssi , Visakorpi Tapio , Tammela Teuvo L.J. , Schleutker Johanna
Published: March 2023

PDF file - 38K, Table includes the results of six tolerance predictors and two protein stability predictors included in Pon-P selected for in silico analysis.
Supplementary Table 2 from HOXB13 G84E Mutation in Finland: Population-Based Analysis of Prostate, Breast, and Colorectal Cancer Risk
Authors: Laitinen Virpi H. , Wahlfors Tiina , Saaristo Leena , Rantapero Tommi , Pelttari Liisa M. , Kilpivaara Outi , Laasanen Satu-Leena , Kallioniemi Anne , Nevanlinna Heli , Aaltonen Lauri , Vessella Robert L. , Auvinen Anssi , Visakorpi Tapio , Tammela Teuvo L.J. , Schleutker Johanna
Published: March 2023

PDF file - 47K, Presentation of segregation analysis.
Supplementary Table 2 from Lifetime Physical Activity and the Risk of Non-Hodgkin Lymphoma
Authors: Boyle Terry , Gallagher Richard P. , Gascoyne Randy D. , Connors Joseph M. , Le Nhu D. , Spinelli John J.
Published: March 2023

Distribution of total, moderate-intensity and vigorous-intensity physical activity performed in specific age-periods by cases and controls in a case-control study conducted in British Columbia, Canada, 2000-2004.
Supplementary Table 1 from Lifetime Physical Activity and the Risk of Non-Hodgkin Lymphoma
Authors: Boyle Terry , Gallagher Richard P. , Gascoyne Randy D. , Connors Joseph M. , Le Nhu D. , Spinelli John J.
Published: March 2023

Distribution of lifetime total, moderate-intensity and vigorous-intensity physical activity by sex and non-Hodgkin lymphoma subtype in a case-control study conducted in British Columbia, Canada, 2000-2004.
Supplemental material from Long-term Ultraviolet Flux, Other Potential Risk Factors, and Skin Cancer Risk: A Cohort Study
Authors: Wu Shaowei , Han Jiali , Laden Francine , Qureshi Abrar A.
Published: March 2023

Supplemental Table 1. Relative risks of basal cell carcinoma according to quintiles of cumulative UV flux stratified potential risk factors in the Nurses' Health Study II (1989-2009). Supplemental Table 2. Relative risks of squamous cell carcinoma according to quintiles of cumulative UV flux stratified by sunburn reaction as a child/adolescent in the Nurses' Health Study II (1989-2009). Supplemental Table 3. Relative risks of skin cancer according to quintiles of cumulative UV flux stratified by host risk score in the Nurses' Health Study II (1989-2009). Supplemental Figure 1. A directed acyclic graph showing the relationships between sun exposure, other potential risk factors, and risk of skin cancer.
Supplementary Figure 1 from Lifetime Physical Activity and the Risk of Non-Hodgkin Lymphoma
Authors: Boyle Terry , Gallagher Richard P. , Gascoyne Randy D. , Connors Joseph M. , Le Nhu D. , Spinelli John J.
Published: March 2023

Physical activity questionnaire used in a case-control study of non-Hodgkin lymphoma conducted in British Columbia, Canada, 2000-2004.
Data from Variation in TP63 is Associated with Lung Adenocarcinoma in the UK Population
Authors: Wang Yufei , Broderick Peter , Matakidou Athena , Vijayakrishnan Jayaram , Eisen Timothy , Houlston Richard S.
Published: March 2023

Abstract
Background: Variation at TP63 has recently been shown to be associated with lung adenocarcinoma in the Asian population.

Methods: To investigate how this finding translates to the European population we compared the genotypes of SNPs annotating the TP63 locus at 3q28 in 4,462 lung cancer patients, including 911 with adenocarcinoma, and 8,235 controls from the United Kingdom.

Results: A statistically significant association between adenocarcinoma risk and SNP genotype was shown: rs10937405, OR = 1.21, P = 1.82 × 10−4; rs17429138, OR = 1.23, P = 7.49 × 10−5; and rs4396880, OR = 1.21, P = 2.03 × 10−4. Haplotype analysis was consistent with a single TP63 risk locus defined by SNPs rs10937405, rs17429138, and rs4396880. While no association between SNPs and small cell lung cancer was shown, the rs10937405 and rs439680 associations were significant for squamous cancer (respective P-values, 0.0022 and 0.02).

Conclusions: These findings show TP63 variation is a risk factor for the development of lung adenocarcinoma in the UK population. Furthermore, they provide additional insight into the subtype-specificity of the 3q28 lung cancer association.

Impact: Our data confirm the association of 3q28 with lung adenocarcinoma and that this association is not confined to the Asian population. Elucidating the functional basis of this association will be contingent on future fine mapping of the TP63 loci. Cancer Epidemiol Biomarkers Prev; 20(7); 1453–62. ©2011 AACR.
Data from Targeted MDM2 Degradation Reveals a New Vulnerability for p53-Inactivated Triple-Negative Breast Cancer
Authors: Adams Clare M. , Mitra Ramkrishna , Xiao Youcai , Michener Peter , Palazzo Juan , Chao Allen , Gour Jitendra , Cassel Joel , Salvino Joseph M. , Eischen Christine M.
Published: March 2023

Abstract
Triple-negative breast cancers (TNBC) frequently inactivate p53, increasing their aggressiveness and therapy resistance. We identified an unexpected protein vulnerability in p53-inactivated TNBC and designed a new PROteolysis TArgeting Chimera (PROTAC) to target it. Our PROTAC selectively targets MDM2 for proteasome-mediated degradation with high-affinity binding and VHL recruitment. MDM2 loss in p53 mutant/deleted TNBC cells in two-dimensional/three-dimensional culture and TNBC patient explants, including relapsed tumors, causes apoptosis while sparing normal cells. Our MDM2-PROTAC is stable in vivo, and treatment of TNBC xenograft-bearing mice demonstrates tumor on-target efficacy with no toxicity to normal cells, significantly extending survival. Transcriptomic analyses revealed upregulation of p53 family target genes. Investigations showed activation and a required role for TAp73 to mediate MDM2-PROTAC–induced apoptosis. Our data, challenging the current MDM2/p53 paradigm, show MDM2 is required for p53-inactivated TNBC cell survival, and PROTAC-targeted MDM2 degradation is an innovative potential therapeutic strategy for TNBC and superior to existing MDM2 inhibitors.
Significance:
p53-inactivated TNBC is an aggressive, therapy-resistant, and lethal breast cancer subtype. We designed a new compound targeting an unexpected vulnerability we identified in TNBC. Our MDM2-targeted degrader kills p53-inactivated TNBC cells, highlighting the requirement for MDM2 in TNBC cell survival and as a new therapeutic target for this disease.
Supplementary Table 1 from Adjuvant therapy with oncolytic adenovirus Delta-24-RGDOX after intratumoral adoptive T-cell therapy promotes antigen spread to sustain systemic antitumor immunity
Authors: Jiang Hong , Shin Dong Ho , Yi Yanhua , Fan Xuejun , Gumin Joy , He Jiasen , Gillard Andrew G. , Lang Frederick F. , Gomez-Manzano Candelaria , Fueyo Juan
Published: March 2023

Antibody information
Transcatheter Arterial Chemoembolization for Treatment-Naive Hepatocellular Carcinoma Has Different Treatment Effects Depending on Central or Peripheral Tumor Location
Authors: Asano Kazuo , Kageyama Ken , Yamamoto Akira , Jogo Atsushi , Uchida-Kobayashi Sawako , Sohgawa Etsuji , Murai Kazuki , Kawada Norifumi , Miki Yukio
Published: March 2023

Introduction: The purpose of this study was to evaluate the treatment efficacy of transcatheter arterial chemoembolization (TACE) for treatment-naive hepatocellular carcinoma (HCC) according to tumor location and burden. Methods: Between 2010 and 2019, consecutive patients who underwent TACE as the first treatment were enrolled. Tumors were classified into two categories based on their location, as central or peripheral tumors. Tumors in the central zone, which is within 1 cm of the main trunk or the first branch of the portal vein, were classified as central tumors, while those located in the peripheral zone were classified as peripheral tumors. Patients were grouped according to the HCC location and up-to-7 criteria. Patients with central tumors were classified into the central arm and those with only peripheral tumors were classified into the peripheral arm. Patients within and beyond the up-to-7 criteria were classified into the up-to-7 in and up-to-7 out-groups, respectively. Local recurrence-free survival (LRFS) and progression-free survival (PFS) were compared per nodule (central tumor vs. peripheral tumor) and per patient (central arm vs. peripheral arm), respectively. The prognostic factors of LRFS and PFS were analyzed by univariate and multivariate analyses. Results: A total of 174 treatment-naive patients with 352 HCCs were retrospectively enrolled. Ninety-six patients and 130 lesions were selected by propensity score matching. Median LRFS was longer for peripheral tumors than central tumors (not reached vs. 3.3 months, p < 0.001). Median PFS was 17.1 months (8.3–24.9) in the peripheral arm and up-to-7 in, 7.0 months (3.3–12.7) in the peripheral arm and up-to-7 out, 8.4 months (4.0–12.6) in the central arm and up-to-7 in, and 3.0 months (1.2–4.9) in the central arm and up-to-7 out-groups. The peripheral arm and up-to-7 in-groups had significantly longer PFS than the other three groups (p = 0.013, p = 0.015, p < 0.001, respectively). Multivariate analysis confirmed that the central zone and central arm were associated with high adjusted hazard ratios for tumor recurrence or death (2.87, p < 0.001; 2.89, p < 0.001, respectively). Conclusion: Treatment-naive HCCs in the peripheral zone had a longer LRFS and PFS following TACE compared to those in the central zone.
Estudo dos efeitos da poluição atmosférica na mortalidade neonatal e fetal na cidade de São Paulo, Brasil
Authors: Nishioka Daniel Cuba , Coura Fernando Luiz Barbério , Pereira Luiz Alberto Amador , Conceição Gleice Margarete de Souza
Published: March 2023

Muitos estudos têm sugerido que crianças e idosos são mais suscetíveis aos efeitos da poluição atmosférica. Poucos enfatizaram os efeitos agudos da poluição em fetos ou recém-nascidos. Utilizando uma abordagem epidemiológica de séries temporais, o presente estudo tem como objetivo investigar a associação de mortes neonatais e mortes fetais tardias com a exposição à poluição atmosférica no ano de 1998, na cidade de São Paulo. Utilizando modelos de regressão de Poisson, encontrou-se uma associação significante entre mortes fetais tardias e os níveis de 03 e N02; o aumento estimado na mortalidade associado a esses poluentes foi de 3,5 e 4%, respectivamente. Para a mortalidade neonatal encontrou-se uma associação significante com 03 PM10 S02 e N02 sendo que o aumento estimado na mortalidade foi de 10%. Estes resultados mostram a importância da poluição atmosférica na saúde, e quanto os fetos e recém-nascidos sofrem com esse problema ambiental.
Modelo experimental de reimplante de membro após isquemia quente em ratos e efeito da estreptoquinase, alopurinol e terapia com oxigênio hiperbárico
Authors: Silva José Carlos Faes da , Simão Danielle Tiemi , Lima Leandro Gregorut , Cunha Marcelo Sacramento , Wada Alexandre , Nakamoto Hugo , Ferreira Marcus Castro
Published: March 2023

A isquemia prolongada leva a alterações na microcirculação tecidual e liberação de radicais livres do oxigênio conhecidos como fenômeno de não reperfusão. Foi realizado amputação com preservação dos vasos e nervos do membro posterior direito em 110 ratos. Os grupos GM1, GM2, GM3, GM4 e GM5 foram submetidos a isquemia quente de 0, 2, 4, 6, 8 horas. As taxas de sobrevida dos membros isquêmicos após 7 dias de avaliação foram 100%, 80%, 63,6%, 50%, 20%. Os grupos GE1, GE2 e GE3 foram tratados com estreptoquinase, alopurinol e terapia com oxigênio hiperbárico após isquemia de 6 horas. As taxas de sobrevida foram 66,7%, 70% e 30%. Os resultados foram analisados estatisticamente pelo teste do Qui-quadrado e considerados significantes quandop<0,05. Os resultados sugerem um aumento significativo da sobrevida de membros isquêmicos após utilização doalopurinol e estreptoquinase. A terapia com oxigênio hiperbárico diminuiu significativamente a sobrevida dos membros isquêmicos.
Cefaléia de origem cervical
Authors: Teixeira Manoel Jacobsen , Yeng Lin Tchia , Altieri Carlos Eduardo , Saito Mateus
Published: March 2023

O papel desempenhado pelas anormalidades da coluna cervical na gênese da cefaléia cervicogênica é destacado. O trabalho é o de análise do papel das disfunções e das anormalidades da coluna cervical na gênese das algias crânio-faciais. É ressaltada a importância da síndromes dolorosas miofasciais na gênese das cefaléias e do tratamento farmacológico e dos procedimentosde medicina física no controle desta condição álgica. A compreensão do papel destas anormalidades é importante, nãoapenas com finalidade de classificação como também para o estabelecimento de condutas terapêuticas em casos de dor crânio-facial.
Violência doméstica e saúde da mulher
Authors: Pedreira Fábio Américo , Kotovicz Fabiana , Souza Fábio Antônio Alves de Jesus , Schraiber Lilia Blima
Published: March 2023

Objetivo: Estudar a prevalência de violência doméstica física e/ou sexual contra a mulher e suas repercussões para a saúde. Materiais e Métodos: O estudo foi realizado no município de São Paulo com 1343 mulheres (15-49 anos) usuárias de 12 serviços públicos de atenção primária à saúde. Resultados: Ao analisar a prevalência de violência física e/ou sexual, 50,2% das mulheres (IC95% = 47,5-52,9%) relataram a ocorrência de pelo menos um episódio em suas vidas, sendo o parceiro o agressor exclusivo na maioria dos casos (57,2%).Sofreram violência doméstica alguma vez na vida 46,8% das usuárias (IC95% = 44,1-49,5%), sendo que 27,9% sofreram unicamente agressão física, 4,5% unicamente agressão sexual,14,4% agressão física e sexual. Conclusão: A violência física e sexual teve alta magnitude entre as mulheres usuárias pesquisadas. Além disso, constatou-se a importância da violência doméstica nessas agressões, notadamente aquelas perpetradas por parceiros, o que indica a importância do estudo no campo da prevenção e atenção à saúde.
Insuficiência renal aguda induzida pelo contraste em pacientes submetidos à cineangiocoronariografia - análise dos métodos de prevenção
Authors: Soeiro Alexandre de Matos , Carlos Alexandre Stievano , Felício Carlos Henrique Chirnev , Luz Daniel Petkevicius , Aldunate Johnny Leandro Conduta Borda , Cabral Richard Halti
Published: March 2023

A insuficiência renal aguda induzida por contraste (IRAIC) é considerada, atualmente, uma importante causa de disfunção renal em pacientes hospitalizados submetidos àcinecoronarioangiografia (CAG). Este achado adquire maior importância quando se verificaque a IRAIC é responsável por um aumento significativo dos índices de morbidade e mortalidadehospitalar. Com o objetivo de evidenciar as principais formas de prevenção e tratamento da IRAIC, realizou-se uma revisão bibliográfica ampla, utilizando as principais bases de dados internacionais. A adoção de medidas de prevenção da instalação da IRAIC como, autilização de N-acetil-cisteína ou do fenoldopam antes da injeção do contraste, foi o método que melhor repercutiu na sobrevida dos pacientes estudados, principalmente naqueles que são diabéticos ou que apresentam algum prejuízo da função renal.
Incidence of Burnout syndrome in Brazilian army military in the amazon region
Authors: Souza Yonel Ricardo de , Feitosa Fabio Biasotto , Bezerra Gabrielle Selleri
Published: March 2023

This study aimed to investigate the Burnout levels and possible predisposing factors among Brazilian Army military who were serving in the Brazilian Amazon. Method: the sample consisted of 122 volunteer military (officers and sergeants) with a mean age of 36.80 ± 6.69 years, 53 were employed in the operational missions (border security, patrol, external and internal defense exercises) and 69 personnel who were employed in the administrative missions (internal logistics). Officers (29) and sergeants (93) were selected who served in Porto Velho, northwestern Brazil. They answered to a sociodemographic questionnaire and the Malash Burnout Inventory, validated for Brazil. Results: scores showed that the levels of burnout in Army military who serve in the region are high. The main sociodemographic, labor, physical and social conditions that were associated with significantly higher levels of Burnout in this study were: reduced length of service, sedentary lifestyle, extra work, lower hierarchical rank and living away from relatives. Conclusion: the interaction between the two instruments found that the military working in the operational area, warrant officers, sergeants, between 6 and 10 years in service, single, who do little physical activity and whose relatives live far away were the ones who had the highest Burnout levels.
Regulamentação do consumo de Cannabis no Uruguai e suas influências sobre a fronteira brasileira
Authors: Tavares Diogo Henrique , Jardim Vanda Maria da Rosa , Franchini Beatriz , Biondi Heitor Silva , Rodrigues Cândida Garcia Sinott Silveira , Bazzan Jéssica Stragliotto
Published: March 2023

Objetivo: conhecer as influências da regulamentação do consumo da Cannabis no Uruguai sobre o consumo desta substância psicoativa na região de fronteira com o Brasil. Método: estudo qualitativo, exploratório e descritivo. Participaram 14 pessoas que usam Cannabis, residentes em uma cidade da fronteira Brasil/Uruguai. Dados coletados por entrevista semiestruturada, analisados através da Análise de Conteúdo. Resultado: as transformações sociais estão relacionadas com a aceitação social do consumo; visualização de pessoas idosas que utilizam a substância e maior interação entre pessoas que usam Cannabis dos países envolvidos. As transformações no consumo estão relacionadas com a possibilidade de se adquirir Cannabis in natura, disponibilidade de variados tipos e subespécies da planta e o fluxo de brasileiros para realizar o consumo no lado uruguaio da fronteira. Conclusão: investigar espaços de fusão social, cultural e política, pode servir para reflexão acerca do atual cenário brasileiro, e implementação de ações que busquem salvaguardar os direitos humanos, respeitando a autonomia, e cuidando sobre a perspectiva de saúde.
IL-37 Attenuates Platelet Activation and Thrombosis Through IL-1R8 Pathway
Authors: Chen Yufei , Hong Jin , Zhong Haoxuan , Zhao Yikai , Li Jian , Shen Wei , Luo Xinping , Shi Haiming , Hu Liang , Liu Junling , Gao Wen
Published: March 2023

Background:

IL-37 (interleukin-37), a natural suppressor of innate inflammatory and immune responses, is increased in patients with myocardial infarction. Platelets play an important role in the progress of myocardial infarction, but the direct effects of IL-37 on platelet activation and thrombosis, as well as the underlying mechanisms, still remain unclear.

Methods:

We evaluated the direct effects of IL-37 on agonists-induced platelet activation and thrombus formation, as well as revealed the underlying mechanisms using platelet-specific IL-1R8 (IL-1 receptor 8)–deficient mice. Using myocardial infarct model, we explored the effects of IL-37 on microvascular obstruction and myocardial injury.

Results:

IL-37 directly inhibited agonists-induced platelet aggregation, dense granule ATP release, P-selectin exposure, integrin αIIbβ3 activation, platelet spreading, and clot retraction. IL-37 inhibited thrombus formation in vivo in a FeCl
3
-injured mesenteric arteriole thrombosis mouse model and ex vivo in a microfluidic whole-blood perfusion assay. Mechanistic studies using platelet-specific IL-1R8–deficient mice revealed that IL-37 bound to platelet IL-1R8 and IL-18Rα, and IL-1R8 deficiency impaired the inhibitory effects of IL-37 on platelet activation. Using PTEN (phosphatase and tensin homolog)-specific inhibitor and PTEN-deficient platelets, we found that IL-37 combined with IL-1R8 to enhance PTEN activity, inhibit Akt (protein kinase B), mitogen-activated protein kinases, and spleen tyrosine kinase pathways, as well as decrease the generation of reactive oxygen species to regulate platelet activation. Exogenous IL-37 injection suppressed microvascular thrombosis to protect against myocardial injury in wild-type mice but not in platelet-specific IL-1R8–deficient mice after permanent ligation of the left anterior descending coronary. Finally, a negative correlation between plasma IL-37 concentration and platelet aggregation was observed in patients with myocardial infarction.

Conclusions:

IL-37 directly attenuated platelet activation, thrombus formation, and myocardial injury via IL-1R8 receptor. Accumulated IL-37 in plasma inhibited platelet activation to ameliorate atherothrombosis and infarction expansion, and thus may have therapeutic advantages as potential antiplatelet drugs.
Evolutionary history drives the geographical distribution of dorsal patterns in the common wall lizard (Podarcis muralis)
Authors: Dadda Thomas , Storniolo Federico , Mangiacotti Marco , Scali Stefano , Zuffi Marco A.L. , Sacchi Roberto
Published: March 2023

Melanin-based dorsal pattern polymorphisms are common in reptiles and generally evolve under the interaction between opposite selective pressures, notably thermal advantage in cold environments and background matching to avoid predation. When those pressures change over space and time, the relative frequencies of morphs can vary across the species range. However, no previous study has analysed the spatial patterns of variation of morphs under a phylogenetic perspective in addition to the adaptive responses to natural selection. In this study, we focused on the distributional patterns of the three dorsal morphs of Podarcis muralis at wide-range scale to assess how they associate with geography, climate, microhabitat, phylogeny and sexual dimorphism. By using open access data from iNaturalist, we assembled a dataset of 4096 georeferenced points with information on sex and morph. Data were analysed through Bayesian GLMs, and four alternative models were formulated depending on the specific factors affecting morphs’ frequency. The dorsal morphs are not randomly distributed in Europe, but follow clear geographic patterns, vary with altitude and habitats, show sex-specific trends, and correlate with the phylogenetic history of the species. When comparing models, the phylogenetic model always obtained the best performance, and no overlap with other models occurred, thus best explaining the distributional patterns of dorsal morphs. The evolutionary processes, in addition to present environmental pressures, can significantly affect local-scale microevolutionary adaptations, influencing the current distribution of dorsal phenotypes across the species range. More generally, results point out the importance of considering the evolutionary processes when analysing distributional patterns of polymorphisms.
A Quantitative Analysis of Smartphone-Based Endoscopy and Video Tower Endoscopy
Authors: Maksimoski Matthew , Maurrasse Sarah E , Valika Taher
Published: March 2023

Objectives:

Examine the differences between traditional tower-based endoscopy (TBE) and smartphone-based endoscopy (SBE) using objective measures of cost, setup time, and image quality.

Methods:

Cost analysis study and randomized single-blinded prospective trial was performed at a tertiary academic health center. Twenty-three healthcare providers, 2 PA-C, 9 residents, 2 fellows, 10 attendings varying in practice from 1 to 27 years were a part of the study. Actual cost analysis was used for purchase of the Karl Storz video tower system and the Save My Scope smartphone-based endoscopy system for cost analysis. For setup time, providers entered a room and were randomized to set up either an SBE or TBE system and timed from room entry to a visible on-screen image. A crossover was then performed so all providers performed both setups. For image discernment, standardized photos of a modified Snellen’s test were sent via text message to providers who were blinded as to which photo represented which system. Practitioners were randomized as to which photo to receive first.

Results:

Cost savings was 95.8% ($39,917 USD) per system. Setup time for the smartphone system was 46.7 seconds less than video tower system on average (61.5 vs 23.5 seconds; P < .001, 95% CI: 30.3-63.1 seconds). Level of visual discernment was slightly better for SBE over TBE, with reviewers able to identify Snellen test letters at a size of 4.2 mm with SBE versus 5.9 mm with TBE ( P < .001).

Conclusions:

Smartphone-based endoscopy was found to be cheaper, quicker to set up, and to have marginally better image quality when transmitted via messaging than tower-based endoscopy, although the clinical significance of these visual differences are unknown. If appropriate for their needs, clinicians should consider smartphone-based endoscopy as a viable option for viewing and collaborating on endoscopic images from a fiberoptic endoscope.
The ‘New Quad’ in the Middle East: Opportunities and Implications for Sri Lanka’s Middle Eastern Relations
Authors: Attanayake Chulanee , Wakkumbura Menik
Published: March 2023

The emerging geopolitical tension and the trade competition in the Indian Ocean urge Sri Lanka to plan its diplomatic ties prudently encouraging Sri Lankan decision-makers to envisage a new strategy for international diplomatic cooperation: minilateralism. This diplomatic engagement mode enables smaller states to cooperate with greater powers in small-scaled/sized cooperation patterns to increase their international opportunities. Since the Indian Ocean has become a hotspot of maritime trade competition and various geostrategic developments, Sri Lanka aspires to new venues for international cooperation. The ‘new Quad’ formed among the United States, India, Israel, and the United Arab Emirates can be a potentially lucrative partnership for a littoral state like Sri Lanka. Amid these developments, this paper seeks to fill a void by delving into the strategic reasons for Sri Lanka’s engagement with the Middle East via minilateralism. This paper investigates the newly strategising affairs of the ‘new Quad’ which two of their member states, Israel and UAE are from the Middle East, and views on how Sri Lanka can benefit in economic ties and crisis management realms to deal with energy and maritime trade issues.
Coercive Control: Transforming Partial Defences to Murder in England and Wales
Authors: Clough Amanda
Published: March 2023

An abused person who kills their abuser remains a conundrum for law and justice. How do we adequately deal with this issue using the current defences to murder? The Coroners and Justice Act 2009 legislated with such situations in mind, but the focus here was on physical abuse. As our understanding of the effects of coercive and controlling behaviour has grown, how fatal reactions to such behaviour might be dealt with by the courts has become an issue of particular interest. This article considers how the current parameters of the criminal law and our increased understanding of intimate partner violence are in conflict, and further legislation will most certainly be necessary to be inclusive of non-physical abuse.
Words Meet Photos: When and Why Photos Increase Review Helpfulness
Authors: Ceylan Gizem , Diehl Kristin , Proserpio Davide
Published: March 2023

Are reviews with photos more helpful? If so, do consumers find reviews more helpful when photos and text convey similar or different information? This article examines the effect of content similarity between photos and text on review helpfulness and its underlying mechanism. Using a data set of 7.4 million reviews associated with 3.5 million photos from Yelp, and applying machine learning algorithms, the authors quantify the similarity of the content between text and photos. They find that, overall, photos increase the helpfulness of a review. More importantly, though, greater similarity between photos and text heightens review helpfulness more. The authors then validate algorithm-based similarity assessments with similarity perceptions of human judges. Using real-world reviews from Yelp and carefully designed stimuli, they replicate the core findings in five laboratory experiments. Further, testing the underlying mechanism, they find that greater similarity facilitates the ease with which consumers can process the review, which, in turn, increases that review's helpfulness to consumers. Finally, they show that factors that impede the ease of processing (e.g., language difficulty or poor image quality) can reduce the effect of similarity on helpfulness. These findings provide novel insights into the value of user-generated content that includes text and photos and its underlying mechanism.