bluuebunny/crossref_metadata_2025 huggingface dataset:
Staining criteria, collection and number of cells evaluated to identify micronuclei in buccal mucosa cells of agricultural workers exposed to pesticides.
Authors: Santiago-Manzano Dayna
Published: July 2021

Although there are several publications that refer to the basic criteria established for the micronucleus (MN) test in exfoliated buccal cells, there is still a difference in the quantity, method of obtention and staining of the cells for the evaluation of the presence of micronuclei. Objective. Identify the criteria for evaluation of MN in oral mucosa cells exposed to pesticide in investigations carried out. Material and methods. A systematic review was carried out on the internet, based on articles published in Crossref, JCR, Scopus, PubMed, Google academic, using keywords such as: micronuclei, buccal mucosa cells, genotoxic damage, pesticides and biomarker. Results. In the six selected articles, four presented statistically significant values ​​with the presence of MN when comparing the exposed groups with respect to the control groups, and the criteria for staining, collection and number of cells evaluated to identify micronuclei were very varied. Conclusions. It is important to follow validated and standardized protocols for the MN oral cytoma assay. Being considered in all the parameters suggested in the protocol will increase the reliability of the studies and will give the possibility of comparing the results obtained.
Empowerment como tendencia organizacional
Authors: De León-Vázquez Irma Isabel , Tapia-Castillo Delia Iliana , Martínez-Cruz Alexa Ariday
Published: July 2021

Siempre han existido los líderes, basta con revisar los libros de historia o cómo se ha manejado la religión. Sin embargo, con la revolución industrial se vuelve el liderazgo objeto de estudio dando origen a una serie de investigaciones y propuestas donde se presentan diferentes tipos de líderes colocados de forma jerárquica donde el protagonismo es un elemento fundamental. En la presentación de este trabajo se muestra cómo es que los negocios han cambiado en su forma de delegar funciones, el mapa conceptual permite observar al empowerment o empoderamiento como tendencia de organización desde el propio concepto de empowerment, su desarrollo, tendencias, objetivos, pilares básico y cambio de estilo.
Inducción a las matemáticas empleando objetos de aprendizaje y diseño instruccional
Authors: Reyes-Fuentes Matilde , Ambrocio-Cruz Silvia Patricia , Vélez-Díaz Daniel
Published: July 2021

El aprendizaje en línea es una forma global y puesta en práctica hoy en día. Las técnicas de enseñanza moderna son de vital importancia para el docente y el estudiante, por su constante capacitación en herramientas tecnológicas y la situación actual en la cual nos encontramos, para contar un sistema educativo actualizado se requiere de tecnologías con uso creciente de juegos digitales y ciencias aplicadas en un entorno de aprendizaje, afectando al estudiante en su formación. El mayor reto que posee un catedrático es la preparación de su contenido con mayor rapidez y concluir exitosamente la sesión de clase a distancia y con gran cantidad de distractores. Cada grupo al que imparte clase posee diferentes personalidades, capacidades y preferencias de aprendizaje. Las generaciones próximas de estudiantes poseen un avance enorme sobre la era digital, propiciando al maestro crear una variedad de actividades que mantengan el interés por aprender. Para obtener una actividad de aprendizaje, debe estar bien diseñada para que el proceso de aprendizaje sea efectivo y con su respectiva implementación. El aprendizaje basado en la integración de complementos preestablecidos juega un papel importante en el profesor, lo que permite que exista la participación, interacción y colaboración en un salón de clases y entregando mejores resultados. La propuesta realizada que presenta este documento permite la elaboración de un material didáctico y práctico para los estudiantes de nuevo ingreso en habilidades matemáticas permitiendo reforzar sus competencias en posibles asignaturas de su carrera profesional.
LESSONS IN HAND WASHING: INFLUENCE OF OCCUPATION, HABIT AND SANITATION ON THE TYPE AND BURDEN OF HAND MICROFLORA
Authors: Osayenum Egwari Louis , Oluseun Akinnola Olayemi , Warrie Effiok William , Musbau Kilani Adetunji , Chukwuma Uzowuihe Xavier , Tolu Adegbayi
Published: July 2021

The hand is an important vehicle in disease transmission both in the healthcare setting and in communities. This study accessed the level of compliance to hand hygiene requirements among different professionals within and outside the hospital setting.in addition to the role of good hand hygiene practice in reducing the microbial population of hands. Structured questionnaire to access compliance by the various study group was analyzed statistically. Swabs of hands and contact surfaces were collected before and after different treatment application ranging from washing with soap, use of or a combination of treatment and assessed . Knowledge of the importance of hand hygiene did not translate to better hand hygiene practice among health workers compared to groups outside the health profession. There was a higher preference for water for anal cleansing after defecation as opposed to the use of tissue paper by male than female (p<0.05). The bacterial load in unwashed hands ranged from 106 CFU/ml for Proteus and Streptococcus species to 1010 CFU/ml for and Staphylococcus species. Hand washing without application of resulted in 1-2 log10 CFU reduction depending on bacterial species (p>0.05). Application of to unwashed hands resulted in 2-7 log10 CFU reduction for most bacterial species (p<0.05). Hands were re-colonized with same flora within one week of decolonizing. The multiple factors associated with re-colonization of decolonized hands pose the question as to how frequent should hands be washed?
Pengembangan Manajemen Pengolahan Sampah Menjadi Aneka Produk Yang Memiliki Nilai Ekonomis Tinggi Untuk Meningkatkan Pendapatan Masyarakat Desa Pijot
Authors: Suryani Embun , Furkan Lalu Muhammad , Serip Sarifudin , Muhdin Muhdin , Ali Muhamad
Published: July 2021

Desa Pijot memiliki potensi wisata bahari yang sangat penting, karena merupakan pintu gerbang terdekat untuk memasuki daerah-daerah wisata Pantai Pink dan 27 gili melalui wilayah perairan. Aspek negatif dari potensi wisata ini adalah sampah. Masyarakat terbiasa membuang sampah sembarangan dan umumnya masyarakat desa membuah sampah di selokan dan pematang sawah, sehingga menyebabkan tersumbatnya saluran air, yang mengakibatkan terjadinya banjir pada musim penghujan. Langkah awal yang dapat dilakukan untuk meminimalkan sampah, terutama sampah rumah tangga adalah melakukan pemilahan antara sampah organik dan sampah anorganik. Sampah organik dapat dijadikan kompos, sedangkan sampah anorganik dapat dijadikan aneka kreasi daur ulang. Namun, pengetahuan masyarakat Desa Pijot terkait manajemen pengelolaan dan pengolahan sampah masih sangat terbatas. Untuk itu, kegiatan ini bertujuan untuk mensosialisasikan manajemen pengelolaan dan pengolahan sampah menjadi berbagai produk yang bernilai ekonomis, sehingga dapat menjadi salah satu kegiatan ekonomi kreatif masyarakat untuk meningkatkan pendapatannya. Pendekatan yang digunakan dalam kegiatan ini adalah Participatory Rural Appraisal yang menekankan keterlibatan masyarakat dalam keseluruhan kegiatan mulai dari perencanaan, pelaksanaan dan evaluasi program. Masyarakat sasaran yang ingin dicapai dari kegiatan ini adalah Pokdarwis dan Kelompok PKK Desa Pijot. Hasil dari kegiatan ini adalah masyarakat sasaran mengalami peningkatan pemahaman dan ketrampilan untuk mengolah sampah organik dan sampah plastik menjadi berbagai produk yang bernilai dan memiliki nilai jual. Sampah organik diolah menjadi pupuk kompos dan pupuk cair, sedengkan sampah plastik diolah menjadi ecobrick dan berbagai produk souvenir berbahan plastik. Melalui pengolahan sampah ini dapat menciptakan lingkungan yang bersih dan mendukung Desa Pijot sebagai destinasi wisata bahari. Selain itu, dengan dilaksanakannya kegiatam PKM ini maka terjadi peningkatan dan perbaikan kemampuan dan ketrampilan masyarakat sasaran yang mendukung terjadinya peningkatan kegiatan ekonomis masyarakat.   Diharapkan melalui kegiatan ini dapat menumbuhkan ide-ide kreatif, untuk mendapatkan hasil yang lebih baik dan lebih bervariasi yang kemudian dapat dijadikan modal awal untuk memulai usaha.
Empowerment of Batik Tulis Groups through the Association
Authors: Yusra Halqi , Sugito Sugito
Published: July 2021

The Giriloyo Batik Tulis Association is confronted with a fundamental challenge: how to maintain and preserve the tradition of batik tulis while the technology-based batik business grows. This study uses a qualitative descriptive approach to describe the empowerment of batik tulis groups in the Giriloyo and  several inhibiting and solutions to issues associated with empowerment of batik tulis groups. The findings show that roles of paguyuban in empowerment are facilitator; coordinator; relation; information; marketing; social control; mediators; evaluation; and innovator. The inhibiting factors are the weakness in the HR sector, generational crisis, facilities, empowerment patterns, management, and unequal vision. The solution to the problems being pursued by the association are  training programs; managing potential resources within the community as employment opportunities for the younger generation,   launching professional personnel in certain fields; sustainable empowerment; grouping tourism village administrators with batik associations; strentening association through deliberation (musyawarah) and consensus (mufakat)
Impact of Commercial Floodplain Aquaculture on Common-pool Resource Dependent Community
Authors: Nazia Tanzina , Daizy Afia Fahmida
Published: July 2021

Aquaculture in pond and floodplain was accelerated in Bangladesh in the 1990s as a means of better production and income which was backed by the donor agencies, NGOs, and the government. Currently, the commercial actors are involved in the aquaculture systems due to the availability of production technologies and inputs. This paper aims to explore how the commercialization and privatization of floodplain aquaculture become the cause of the sufferings of the natural resource-dependent people and biodiversity loss in the floodplains. Now, Influential people hold control of the common pool floodplains and restricted the access of the Small-Scale Fishers (SSF) to manage the aquaculture. Our findings suggest that the SSF, for whom the seasonal floodplains were an important source of livelihood, their livelihood has been destroyed and overall wellbeing have been negatively affected. Besides that, lending enough evidence to the increased inequality, a new group of poor has emerged. Because instead of ensuring the welfare of SSF, Bangladesh government has leased the floodplain lands to the powerful rich people. In addition to growing inequalities, natural resource degradation has welcomed social vulnerabilities. However, no development initiative will ever be sustainable and effective if the existing socio-ecological setting is not considered. Bangladesh government should take robust attempts to revisit fisheries policies to ensure livelihood resilience of fisheries resource-dependent community by managing the access rights of the common pool resources.
Pengaruh Disiplin Ilmu Terhadap Kecenderungan Mahasiswa Dalam Mengakses Informasi Melalui Media Sosial Menggunakan Metode Chi Square
Authors: Palupi Retno , Winarsih SM Santi
Published: July 2021

Social media becomes necessity that is always consumed by many levels of society to looking for such of information. Social media services provide many features that make users can enjoying seaching in cyberspace. All the level of society, all the level of social background and all the level of professions are very familiar with various social media. Social media services on gadgets have facilities to obtain information quickly and easily, such as Facebook, Instagram, YouTube and etc. This study examines the usage of smartphones to determine whether there is a significant effect of students from various disciplines on the tendency of students to access the information needed to support assignments or to find out the required data through social media. The Chi Square method is used as a testing method to determine the effect of disciplines on student tendencies in accessing information topics through social media. The data analysis gave the measurable results based on quantitative data and interesting information. The results showed that the influence of the field of study on students’ Tendencies depend on intensity time in accessing social media.Keywords: disciplines, information topics, social media, chi square method
Viagens na Minha Terra. Esplorazioni iberiche della prossimità (cibo e thanaturismo)
Authors: Bou Enric
Published: July 2021

The chapter takes as starting point a famous book by Almeida Garrett, Viagens na Minha Terra (1846), one of the first books to explore a nearby reality in the Iberian area, a mixed genre work, fundamental in the construction of the Portuguese national identity through the author’s journey to Portugal. It is an internalised landscape from which many historical or fantastic episodes arise related to themes that the author expresses: the violence of war, the joke of the gothic novel, anti-religious criticism about the parasitism of the friars. The purpose of this article is to reflect on several examples of proximity travel written by Iberian authors: José Pla, Viaje en autobús (1942), Camilo José Cela, Viaje a la Alcarria (1946) and José Saramago, Viagem a Portugal (1981). These travel books take advantage of the travelogue feature: to travel, but also to express opinions, analysis and criticisms with the eyes of the essayist, so that the result is much more than a simple guide, with the advantage that travellers are profound connoisseurs of the reality they visit.
Letter of Quintus Oppius Proconsul to Aphrodisias
Authors: Ferraioli Ferdinando
Published: July 2021

The inscription contains a letter sent by the Roman proconsul Oppius to the magistrates, the Council and the demos of the polis of Aphrodisias. In the letter, Oppius affirms that he has met the envoys of Aphrodisias in Kos and has received from them a decree of congratulations for his release. He also testifies to the help obtained by Aphrodisias when he was besieged at Laodicea by the troops of Mithridates and promises to help the city ​​as far as possible. Finally, he agrees to become the patron of the city; it is one of the oldest attestation of the request for patronage made by a city of the Greek world to a Roman magistrate.
Catarse do I Encontro dos Estágios amalgamados pela música no Ensino de Química: possibilidades de interação entre a escola e a universidade
Authors: Lupinetti Joice Menezes , Marques de Oliveira Adriana
Published: July 2021

Neste artigo tecemos discussões sobre o evento intitulado de I Encontro dos Estágios em que a música amalgamou todo o processo. Foi desenvolvido na Universidade Federal da Grande Dourados (UFGD) na cidade de Dourados, Mato Grosso do Sul, no ano de 2019. Os atores envolvidos foram estagiários do curso de Licenciatura em Química, professores da Educação Básica e professores do Ensino Superior. Nosso objetivo foi de investigar o delineamento das etapas dos Estágios Supervisionados I e III que reverberaram no I Encontro dos Estágios. Para isto, utilizamos como material de análise 18 portfólios desenvolvidos pelos licenciandos e os diários das professoras/pesquisadoras. Fundamentamos na pesquisa participante e utilizamos a Análise de Conteúdo (AC) para compreensão deste material empírico. Esta abordagem nos oportunizou compreender as emoções despertadas nos sujeitos durante o desenvolvimento deste Encontro e as vivências possibilitadas pela música, além do papel da interação e do diálogo na formação dos futuros professores.
ENERGIZING THE CITY:PLTS CHARGING STATION UNTUK TAMAN PUBLIK DI KOTA SEMARANG, PROVINSI JAWA TENGAH
Authors: Nagel Archibald Anugroho , Sinaga Nazaruddin
Published: July 2021

Peraturan Daerah Provinsi Jawa Tengah Nomor 12 Tahun 2018 Tentang Rencana Umum Energi Daerah Provinsi Jawa Tengah mengamanatkan target pemanfaatan energi baru terbarukan (EBT) pada tahun 2030 sebesar 21,32%. Hingga tahun 2020 telah tercapai pemanfaatan EBT sebesar 11,89% sehingga diperlukan sebesar 9,43% untuk memenuhi target di tahun 2030. Salah satu potensi EBT yang cukup melimpah di Jawa Tengah adalah energi surya. Potensi ini juga didapati di Ibukota Provinsi Jawa Tengah, yakni Kota Semarang dengan letakgeografisnya yang berada di pesisir Jawa Tengah. Berdasarkan hal tersebut, pemanfaatannya energi surya perlu terus disosialisasikan pemanfaatannya untuk seluruh stakeholder. Salah satu sarana sosialisasi dan edukasi yang dapat diterapkan adalah pemasangan PLTS Charging Station (PLTS-CS) di area publik, seperti taman kota. Penelitian bertujuan untuk mengetahui potensi dan kelayakan pemasangan PLTS-CS di taman yang berada di Kota Semarang yaitu Taman Simpang Lima (Pancasila) dan Indonesia Kaya. Metodologi yang digunakan meliputi observasi lapangan untuk mengetahui kondisi area tersedia dan insolasi matahari sewaktu serta analisis melalui simulasi dengan perangkat lunak PV Syst untuk mengetahui potensi pembangkitan dan profil beban desain PLTS-CS. Hasil simulasi menunjukkan bahwa pada taman Pancasila (Simpang Lima) dan Indonesia Kaya menunjukkan bahwa potensi pembangkitan PLTS-CS dengan modul surya berkapasitas 2 x 250 Wp dapat menghasilkan daya rataan lebih dari 800 kWp per tahun, dengan rencana beban 2 (dua) buah lampu kapasitas masing-masing 10 watt dan fasilitas pengisian daya sebesar 75 watt maka beban harian sebesar 2,1 Wh perhari. Berdasarkan hasil simulasi tersebut maka sistem PLTS-CS dapat diperhitungkan layak untuk dibangun.Kata Kunci: PLTS, Charging Station, Kota Semarang, Energi Surya
EXTRACTING ESSENTIAL OIL FROM FRAGRANT LEMONGRASS PLANTS BY STEAM-HYDRO DISTILLATION METHOD USING MICROWAVE AS A HEATER
Authors: Safitri Aida , Sinaga J. P.
Published: July 2021

This research studies the process of extracting citronella oil by the steam-hydro distillation method with microwaves (microwave). In addition, study the effect of temperature (105 ͦ C, 110 ͦ C, 115 ͦ C) and the size of the material enumeration (0.5 cm; 1 cm; 1.5 cm) on the yield of oil produced. This research was conducted by the steam-hydro distillation method. In this method a solvent is added in the form of water to dissolve the oil in the fragrant lemongrass stems and leaves. The resulting steam is condensed and then distillate in the form of a mixture of oil and water is taken after 120 minutes and separated using a separating  funnel. From the results of the study, it was found that the% yield of high citronella oil in the variable size of the enumeration material was 0.5 cm at a temperature of 115 with a yield of 1.92%. The content of Citronella obtained in the oil of this research is 59.28%. The density of lemongrass oil is 0.875. The refractive index value is obtained in the range of 1.46735- 1.46925.Keywords :  Essential Oil, Fragrant, Steam-hydro Distilation, Microwave
PEMBUATAN POLIURETAN ELASTOMER RAMAH LINGKUNGAN BERAZASKAN JATROPHA OIL
Authors: Ilhani Vera
Published: July 2021

Pada penelitian ini dilakukan tentang pembuatan poliuretan berbasis Metilen difenil diisosianat (MDI) dan minyak jarak pagar  dengan menggunakan etil asetat, dibutiltin dilaurat, metal laurat, nano tio2 , pentaeritritol, dan aquades sebagai pengisi tambahan yang bertujuan untuk meningkatkan sifat mekanik poliuretan. Tujuan penelitian ini adalah untuk menentukan pengaruh massa MDI dan minyak jarak pada pembuatan poliuretan dengan memvarisikan bahan utamanya. Karakteristik analisa stabilitas termal menggunakan alat TGA (Thermo Gravimetric Analyzer) menunjukkan keandalan termal yang sangat baik memiliki stabilitas termal, kapasitas penyimpanan panas laten yang tinggi, dan stabilitas siklus termal yang unggul dengan ketahanan termal hingga 403.65C°C. Pada analisa gugus fungsi menggunakan FT-IR spektroskopis gugus N-H pada daerah separan 132.24 cm-1,  pada daerah serapan 3620.39 cm-1 merupakan gugus O-H dan daerah serapan 1541.12 cm-1  merupakan gugus C=C (MDI). Sedangkan analisa struktur morfologi menggunakan alat SEM (Scanning Electron Microscope) pada sampel PU sampel A memiliki permukaan halus dan menandakan partikel padat sebagai penstabil yang baik (emulsi pickering) dibangdingkan dengan sampel B yang menunjukkan beberapa bentuk agregat yang menggumpal dan berpori-pori besar, serta permukaan yang lebih halus.Kata kunci : Poliuratan, MDI, Minyak Jarak, PCM
Los Geoparques Mundiales de la UNESCO en España: entre divulgación científica y desarrollo turístico
Authors: González Tejada Catalina , Girault Yves
Published: July 2021

España es el primer país europeo y el segundo a nivel mundial con mayor número de Geoparques Mundiales de la UNESCO (GMUs), además de haber sido uno de los pioneros mediante el Parque Cultural del Maestrazgo. Sin embargo, las investigaciones relacionadas con esta figura, desde campos de estudio diferentes a las Ciencias de la Tierra, son muy pocas. Este texto propone un análisis multidisciplinario de los procesos de patrimonialización de los 11 GMUs y los dos territorios aspirantes en España entre el periodo de 2015 y 2017, movilizando aportaciones de investigaciones museológicas y geográficas. Los resultados ponen en evidencia un cierto número de ambivalencias en el contexto nacional español, entre las directrices de la UNESCO para los GMUs, y los intereses, representaciones y declaraciones de intención dentro de las estructuras de gestión en cada uno de estos territorios, demostrando la presencia de conflictos epistemológicos y de lógicas antinómicas, que limitan las posibilidades de co-construir un relato territorial y de tener un enfoque holístico, priorizando finalmente uno de los tres objetivos (educación, conservación y desarrollo) que definen el concepto de GMU. Los resultados incitan in fine a repensar el sistema de evaluación y revalidación de esta figura.
El papel de la administración local en la reutilización del patrimonio
Authors: Torres Camacho Jesús Nicolás , Aceituno Luengo Fernando
Published: July 2021

En 1972 la Comisaría General del Patrimonio Artístico Nacional inició expediente para la declaración del Convento de la Purísima Concepción de Torrijos (Toledo) como monumento nacional. El objetivo de este estudio es analizar la evolución de este relevante edificio como convento de clausura y profundizar en la gestión multiescalar de la administración, así como en el papel de los actores privados implicados directamente en su devenir. A través de la labor heurística en archivos (locales, provinciales, regionales y nacionales) y la consulta de las fuentes hemerográficas, se expone la complejidad de las acciones y los trámites necesarios para la preservación de un bien en el contexto temporal del franquismo a la democracia. La materialización de este proyecto en 1981, y la posterior reutilización del edificio como sede local del Ayuntamiento de Torrijos, supuso el punto de partida de la gestión del patrimonio monumental por parte del consistorio que, años más tarde, ha tomado forma con la recuperación de otros bienes como el Yacimiento Arqueológico de Santa María de Jesús o el Hospital de la Santísima Trinidad.
Rehabilitation of Patients with Benign Prostate Hyperplasia with Urinary Bladder Decompensation
Authors: Sarychev Leonid , Savchenko Roman , Sarychev Yaroslav , Sukhomlyn Serhii , Pustovoyt Hanna
Published: July 2021

The article is devoted to the problem of bladder decompensation and related complications in patients with BPH.

The objective: to study the effectiveness of certain methods of restoring the functional capacity of the detrusor in patients with BPH with bladder decompensation.

Materials and methods. The results of treatment of 149 patients with BPH with bladder decompensation aged 47 to 83 years (68,3±7,9) were analyzed, the proportion of which was 39,11 % of the total number of operated on BPH. Two groups of patients were formed by random sampling – every 2–3 patients. Group I included 30 people who underwent cystostomy. Group II included 30 people who, in addition to cystostomy, underwent metabolic-corrective and anticholinesterase therapy. The complex of drugs included B vitamins: octothiamine – 25 mg, riboflavin – 2,5 mg, pyridoxine hydrochloride – 40 mg, cyanocobalamin – 0,25 mg 3 times a day for 4 weeks; Anticholinesterase drug – ipidacrine 20 mg 3 times a day for 4 weeks.

Results. According to the results of pathomorphological examination in both groups of observation there was desquamation of the urothelium, growth of connective tissue, bundles of nerve fibers with the phenomena of dystrophy. Degenerative changes in smooth muscle cells were accompanied by a decrease in the proportion of muscle tissue and a decrease in the diameter of leiomyocytes. However, in patients who underwent preoperative metabolism-corrective therapy, the diameter of the lumen of the arterioles was 20.21 % larger (p<0,05), the wall thickness of the arterioles – 31,73 % smaller (p<0,05), the Kernogan index is 28,22 % lower (p<0,05), the diameter of the capillaries is 3,52 % higher (p>0,05). The diameter of leiomyocytes was 45,26 % larger (p<0,05), the proportion of connective tissue in the bladder wall – 29,14 % lower (p<0,05). Compared with patients who underwent only cystostomy, after metabolic-corrective and anticholinesterase therapy in the short and long postoperative period were better indicators of functional capacity of the detrusor. 6 months after the second stage of the operation according to uroflowmetry Qmax was higher by 32,92 % (p<0,05), Qave – higher by 62,27 % (p<0,05), IPSS – lower by 33,18 % (p<0,05) and the QoL index is better by 29,54 % (p<0,05).

Conclusions. Bladder decompensation due to untimely removal of the obstructive component is the main cause of unsatisfactory treatment results in patients with BPH. Anticholinergic exercise may be an additional factor in bladder decompensation in patients with BPH. Metabolism-correcting and anticholinesterase therapy permit to restore detrusor function by eliminating microcirculatory disorders and energy deficiency, stimulating neurotransmitter, neuromuscular conduction and smooth muscle contraction. In patients with megacystis, additional surgical correction by duplication allows the bladder to be emptied.
Phobic Dispareunia: a Case Report
Authors: Kocharyan Garnik
Published: July 2021

A case of phobic dyspareunia is described. We are talking about a 22-year-old girl whose genital pains first arose 2 years ago during intercourse with a man whose penis length was 25 cm. She had only 5 intercourses with him, and then because of these pains interrupted the relationship with him. Now she is dating a 22-year-old guy who lives in another city, and they come to visit each other. Genital pains and burning in the vagina occur in her not only during intercourses with him and after their end, but even when they are in different cities. In the latter case, they arise when she is planning a trip to another city, involving sexual contacts with her boyfriend (wakes up at night and experiences genital pain and burning sensation “to tears”). Because of this, she cannot sleep. When such a trip is not supposed, then she does not have pain and burning sensation in the genitals. It so happens that the patient comes to her boyfriend, but they do not perform vaginal intercourse, and everything is limited to petting and oral sex. This is preceded by her request to him, and he is sympathetic to her problem. But pains in the genitals occur even with cunnilingus, if not only the clitoris but also the vagina is involved (“bakes, pricks, gives birth to hedgehogs”). She reports that it so happens that pains arise when she comes to her boyfriend, but the matter has not yet come to sexual contact. Before intercourses, she notes the presence of a fear of pain associated with their implementation. This fear is accompanied by tension in the muscles of the body and difficulty in breathing.

Currently, sexual desire is sharply weakened, which can be explained by the presence of dyspareunia. During the examination by the gynecologist, no profile pathology was revealed in the patient. Appropriate cognitive influences and 10 sessions of hypnosuggestive programming were carried out. As a result of the therapy, she stopped avoiding sexual intercourses, began to live a regular sex life, pain during and after intercourses practically ceased to arise, libido was increased.
Photoselective Laser Vaporization of the Prostate in Benign Prostatic Obstruction: Sexual Function in Focus
Authors: Gorpynchenko Ihor , Sytenko Andrii , Vintoniv Oksana
Published: July 2021

The objective: to determine the effect of photoselective laser vaporization (FVP) on individual IIEF domains (sexual activity, libido, erection, ejaculation, ograzm, satisfaction with intercourse) in sexually active men with BPO, as well as the factors on which this effect depends.

Materials and methods. 95 sexually active patients with benign prostatic obstruction (BPO) (prostate volume >40 cm3, maximum urinary flow rate Qmax <10 ml/s; QoL≥4) at the age of 45 to 60 years underwent FP (GreenLight XPS, MoxyFiber) ... Sexual function (IIEF), urination parameters (PSS/QoL, PVR, Qmax), prostate volume, intravesical prostate protrusion, PSA were assessed before the intervention and 3 months after.

Results. PVP had a statistically significant and clinically significant effect on micturition parameters characterizing obstruction, prostate size and QoL. The median IPSSobstructive decreased by 6 (4–7) points (W=7.6; P<0.01), PVR by 48 (38–60) ml (W=6.2; P<0.01), IPP by 0.9 (0.5–1.5) cm (W=9.4; P<0.01) Vprostate at 31 (22–42) cm3 (W=8.5; P<0.01), QoL by 3 (2–4) points (W=11.2; P<0.01). The median Qmax increased by 23 (15–29) ml/s (W=13.3; P<0.01). The median values of the IPSSirritative and IPSSnocturia domains did not change significantly (P<0.8 and P<0.6, respectively). At 3 months after PVP, 84 (94.6 %) patients restored sexual activity. In 33 (39.28 %) of them, an improvement in erection and 15 (17.85 %) deterioration were found. 61 (72.26 %) lost emission.

Conclusions. The most significant effect of PVP on ejaculatory function is the loss of emission. The effect of PVP on erection is multidirectional and manifests itself in its improvement and deterioration. Further research is needed to determine the mechanisms by which PVP affects erection and ejaculation in order to prevent negative effects.
Influence of Connective Tissue Dysplasia Syndrome on Male Reproductive Function
Authors: Gurzhenko Yurii , Kaluzhny Danylo , Feldman Oksana
Published: July 2021

The work demonstrates the influence of undifferentiated connective tissue dysplasia on male reproductive function, shows which dysplastic-dependent pathology of the male genital area affects the spermogram indices in men. Shown are local problems of deep pathophysiological and histological prerequisites in their development of the male factor of infertility in a married couple. The paper demonstrates the importance of the principles of joint work of related specialists at various stages of diagnosis, treatment and subsequent dispensary observation of patients with DSTS, taking into account the polyetiology and multifactorial nature of the pathologies of the genitourinary system caused by DSTS.

The main diagnostic criteria for collagenopathies are minor anatomical anomalies of development, namely, the presence of three or more minor anatomical anomalies of development indicates a high probability of morphogenesis disorders in the form of congenital malformations of the male genital area. The role of the unfavorable course of the early prenatal period, during which the influence of an unfavorable factor can lead to one or another anomaly, for many organs, including the reproductive organs in men, has been revealed, since they are associated with DSTS pathology and are caused by a wide representation of connective tissue. It also demonstrated a great role in the development of non-hereditary forms of exposure to environmental factors, which makes it possible to make a correction with the help of appropriate recommendations. The data presented in the robot can be considered as a certain stage in the study of DSTS problems and its impact on the male reproductive system.
COVID-19 and Cardiovascular Disease: Issues of Diagnosis and Treatment
Authors: Korzh Oleksii
Published: July 2021

COVID-19 affects not only the respiratory system, but also the cardiovascular system. The damage to the cardiovascular system in COVID-19 is multifactorial and several mechanisms are involved, including direct invasion, inflammation, thrombosis, autoantibody synthesis, and oxygen imbalance. The inflammation causes the release of cytokines, especially interleukin-6, and damage to cardiomyocytes. The overproduction of cytokines leads to an abnormal inflammatory response called a cytokine storm, which is believed to be the culprit in cardiovascular events in COVID-19 patients.
Cardiovascular disease is common in patients with COVID-19, and these patients are at increased risk of morbidity and mortality. There is still no data on cardiac dysfunction due to myocardial damage in patients recovering from COVID-19. Most often, this is normal heart function after complete recovery. But often there are myocardial damage and an increased level of troponin as a marker of the severity of the disease associated with a cytokine storm, hypoxia, vasopressors and blood clotting disorders. It is important for every physician to make a differential diagnosis between decompensated heart failure complicated by pulmonary infection and COVID-19 infection. Monitoring and influencing myocardial injury is extremely important in critically ill patients.
Treatment of COVID-19 patients with cardiovascular complications is mostly supportive. The role of pharmacological blocking of the reninangiotensin-aldosterone system in patients with cardiovascular disease and COVID-19 infection requires further research as the relationship appears to be very complex. To date, professional cardiological societies do not recommend canceling ACE inhibitors or agiotensin II receptor antagonists for patients taking these drugs for other indications. Special care should be taken about the potential cardiovascular side effects of the various therapies used to treat viral infections. When using them, daily monitoring of the QT interval on the ECG is proposed.
Current Issues of Purpose and Control of Antihypertensive Therapy in Outpatient Practice (Clinical Case)
Authors: Babynets Liliia
Published: July 2021

The World Health Organization identifies hypertension (AH) as «the world’s leading global risk of increased mortality from cardiovascular disease». AH is one of the most serious health problems because of its prevalence and importance. Caring for a patient with AH with or without chronic comorbidity requires a long-term holistic, patient-centered approach. The goal of treating a patient with AH is to reduce the overall cardiovascular risk, notu jst to control blood pressure.
The aim is to analyze the possibilities of basic drug therapy and control over its implementation in patients with hypertension in different clinical situations in the practice of a family physician.
Newly detected AH in a patient requires careful examination and appointment of effective comprehensive treatment. The tactics of selection of antihypertensive treatment for a patient with newly diagnosed hypertension are considered on a clinical example. Improving lifestyle and healthy living habits are necessary for all patients with AH, even when antihypertensive medication is mandatory. It is important to regulate blood pressure. The choice of medication depends on the patient’s characteristics and comorbidities.
Care of a patient with hypertension should be carried out holistically with the identification and control of additional risk factors and complications, in parallel with the control of hypertension. At the same time it is necessary to take care of the treatment of some other somatic diseases or mental disorders that may affect the outcome of treatment of hypertension.
Effectiveness of Hepatoprotectors in the Practice of a Family Doctor
Authors: Zaremba Yevheniia , Smaliukh Olha , Zaremba Olha
Published: July 2021

Hepatoprotectors – drugs that form the basis of pathogenetic treatment of various liver diseases. They help restore impaired hepatocyte function, increase the resistance of liver cells to the effects of pathological factors, enhance the detoxification function of hepatocytes, have antioxidant properties. There is no generally accepted classification of hepatoprotectors today, they are divided into several groups depending on the origin: plant, animal, synthetic origin, products containing essential phospholipids, amino acids, vitamins, and other groups.
One of the well-known hepatoprotectors of plant origin is glycyrrhizin – the main active ingredient of licorice root. Licorice root (Glycyrrhiza glabra) is a drug used in medicine since ancient times, as evidenced by historical data from China, Japan, India, Greece, and Europe. Licorice root is widely used today in medicine and the food industry. Glycyrrhizin – potassium and calcium salt of glycyrrhizinic acid, has a wide range of properties. It is used mainly for the treatment of chronic liver disease. In non-alcoholic fatty liver disease, the use of glycyrrhizin helps reduce steatosis, inflammation in the liver has an antifibrotic effect. Studies on the use of glycyrrhizinic acid in hepatocellular carcinoma are actively conducted, as its antitumor properties are known. It is included in the treatment of chronic viral hepatitis. In vitro studies have shown the antiviral activity of glycyrrhizin against HIV-1, SARS-associated virus, respiratory syncytial virus, arboviruses, and its potential for coronavirus control is being discussed. Possibilities of application of glycyrrhizin and cardiovascular diseases are studied. In this article, we present a review of current literature data on glycerol, its properties, and applications in liver disease, other diseases, and our own clinical observations.
Rehabilitation of Rheumatic Patients in Primary Care
Authors: Khimion Liudmyla , Burianov Oleksandr , Yashchenko Oksana , Danylyuk Svitlana , Sytyuk Tetiana , Kicha Nataliia
Published: July 2021

The evidence base for use of different rehabilitation programs is discussed in the article. The most effective approaches to the rehabilitation organization and patients education are presented together with the different types of physical rehabilitation, ergotherapy and physical activities useful for the development of the maximum functional ability and social integration of rheumatic patients. The positive impact of the motivational interview in work with rheumatic patients, the results of the clinical studies on evaluation of the patients education influence on their functional abilities and psychologic status; recommendations on ortheses use are discussed in the article.

The recommendations of the leading international expert groups about exercises, physiotherapy, ergotherapy prescribing to the patients with rheumatoid arthritis, osteoarthritis and connective tissue systemic diseases are given; the attention is drown to the methods of evaluation of patients physical status; patients education about energy saving technologies use for maximum possible functional and physical loads and patients autonomy at hom aend social life realization.

Implementation of the given rehabilitation algorithms can help to realize holistic patient-centered approach, improve patients quality of life and functional capacity.
Factor of Basic Pharmacologic Therapy in DSME Applying
Authors: Matіukha Larysa , Smal Bohdan
Published: July 2021

The objective: to investigate the influence of the scheme of basic pharmacologic therapy on the dynamics of carbohydrate and lipid metabolism in a group of patients with type 2 diabetes on the background of the use of group DSME.

Materials and methods. The study was performed on the basis of the Department of Family Medicine and Outpatient Care within the territorial boundaries of the Kyiv agglomeration. The study included 117 patients with type 2 diabetes. The study group of patients was randomly divided into a groups of classroom training (38 people), a group of remote training (39 people) and a control group (40 people), which did not receive additional training load. Subsequently, patients from the study groups took the appropriate course in classroom (outpatient) or remote (using Skype video conferencing) formats. The education of patients methodically and meaningfully complied with the consensus recommendations of the American Diabetes Association, the American Association of Diabetes Educators and the Academy of Nutrition and Dietetics. Subsequently, the relevant indicators of diabetes were monitored at 3 and 12 months after the start of the study and the correlation of their dynamics with the basic scheme of pharmacologic therapy ts and its change during the observation period was analyzed.

Results. During the observation period, changes in the scheme of hypoglycemic and hypolipidemic therapy were made in 10 (8,5 %) and 20 (17,0 %) patients. It should be noted that the relevant changes were bilateral, both in the direction of simplification and in the direction of intensification of drug therapy regimens. Analysis of the ratio of 3- and 12-month dynamics of carbohydrate and lipid metabolism and the scheme of hypoglycemic and hypolipidemic therapy in all study groups did not reveal a significant correlation.

Conclusions. There is no significant correlation between the basic scheme of hypoglycemic and hypolipidemic therapy with the dynamics of carbohydrate and lipid metabolism at the stages of 3- and 12-month check-points. The lack of influence of the pharmacologic therapy scheme on the positive dynamics of diabetes mellitus emphasizes the importance of group DSME in patients with type 2 diabetes mellitus as a separate independent factor of improving of the disease.
Prenatal perineal findings and possible clinical scenario
Authors: Оshovskyy V.I.  , Antonenko N.M.
Published: July 2021

The fetus’s perineal area has not traditionally been the focus for the prenatal echoscopy, mainly because adequate visualization depends on fetus’s position. However, it is precisely thanks to the targeted attention to the perineal area that we sometimes manage to find not only quite curious but clinically significant findings.Sacrococcygeal teratoma can grow large and affect the natural birth process. When localized in the perineal region, it sometimes leads to defecation and micturition disorders. In addition, intestinal loops may be located in the tumor structure, which leads to deformation and the risk of hernia formation. In the presence of a giant sacrococcygeal teratoma, the following events may occur: heart failure leading to fetal hydrops, obstruction of the urinary tract, obstruction of the gastrointestinal tract, impaired innervation of organs due to compression, intratumoral hemorrhage, intrauterine anemia. Hymenal pathology is quite rare in everyday clinical practice. Usually, it is one of the two most common nosologies: hymenal polyp or imperforate hymen. These two anomalies occur almost exclusively in childhood or immediately after menarche. At a later age, the preserved or dysmorphic hymen can present difficulties in diagnosing and treating intravaginal pathological processes. In this article, we would like to bring to your attention two clinical cases with different prognosis to draw colleagues’ attention to the need for a targeted assessment of the perineal area and correct prenatal counseling for a couple, because the ranking of the severity of the probable consequences is significant. Thus, some findings will require only adequate monitoring in childhood, others – may be the cause of premature birth, changes in delivery tactics or immediate surgery after birth.
Constipation – actual problem in pregnancy
Authors: Romanenko T.H. , Morozova O.V. 
Published: July 2021

The objective: is to develop a complex program for the treatment of constipation in pregnant women, including the use of Probiotic.Materials and methods. 60 pregnant women were surveyed: 30 women of group I received the proposed treatment-and-prophylactic measures, and in 30 pregnant women of group II pregnancy was conducted by traditional methods.In order to improve the intestinal microflora of pregnant women of group I was prescribed: universal Probiotic 1 capsule per os 3 times per day for 30 days 2 courses – at 12–16 and 26–30 weeks of pregnancy.Results. In pregnant of group I increased the obligate flora with a decrease in their baseline, that is, only 10.0% of women of bifidobacteria did not exceed 105 CFU/ml and accordingly 6.7% indigenous lactoflora was less than 105 CFU/ml. At the same time, the number of women with reduced obligate flora who did not receive treatment for intestinal dysbiosis remained significantly higher (p<0.05).The number of pregnant with dysbiosis among women in group I (46.7 %) was significantly lower compared to women in group II (100.0%). The III degree of dysbiosis was not observed in any case with the proposed treatment, but it occurred in every third pregnant group II. Significant increase in the normal population of bifidobacteria and lactobacteria (105 and higher CFU/ml) was observed in pregnant women of group I. Symptoms of threat of termination of pregnancy in women of group II (20,0%), and in patients of group I – (10,0%). Premature discharge of amniotic fluid, was found to be significantly less frequent (23.3% versus 46.6% in group II, p<0.05).The threat of preterm birth was recorded in 10.0% of pregnant women in group II, and in group I in one woman (3.3%). Anemia was more common in group II than in pregnant group I (56.7% versus 26.7%). The decrease in the frequency of exacerbation of chronic and the occurrence of gestational pyelonephritis among pregnant women of the I group was determined.Conclusions. The conducted researches showed high efficiency of application of symbiotic of Probiotic for the purpose of normalization of evacuation function of intestine in pregnancy, normalization of intestinal microflora. This, in turn, helped to reduce the frequency of the threat of termination of pregnancy, premature discharge of amniotic fluid, premature birth, anemia, exacerbation of pyelonephritis.
Justification of the choice of diosmin vasoprotective as a preventive agent of pre-eclampsia
Authors: Frolova N.A. , Tezikov Y.V. , Lipatov I.S.
Published: July 2021

In this study, the effectiveness of vasoprotective Diosmin for the prevention of pre-eclampsia in pregnant women of high-risk group with severe forms of placental insufficiency was evaluated. The choice of prophylactic agent in the clinical group is justified by close pathogenetic relationship between placental insufficiency and pre-eclampsia on the one hand, and proved fetoprotective action of Diosmin in case of placental insufficiency on the other hand. It is shown that a normalizing effect on the uterine-placental- fetal blood flow, the functional state of the endothelium of blood vessels, the production of growth factors, the induction of apoptosis of immunocompetent cells by trophoblasts, metabolism and angiogenesis in the placenta, contributes to clinically significant reduction in the frequency of implementation of fetoplacental complex pathology and pre-eclampsia.