bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of weightlessness on the cardiovascular system: a systematic review and meta-analysis
Authors: Mendes Zambetta Rafaella , Signini Étore De Favari , Ocamoto Gabriela Nagai , Catai Aparecida Maria , Uliam Nicoly Ribeiro , Santarnecchi Emiliano , Russo Thiago Luiz
Published: July 2024

Background: The microgravity environment has a direct impact on the cardiovascular system due to the fluid shift and weightlessness that results in cardiac dysfunction, vascular remodeling, and altered Cardiovascular autonomic modulation (CAM), deconditioning and poor performance on space activities, ultimately endangering the health of astronauts.

Objective: This study aimed to identify the acute and chronic effects of microgravity and Earth analogues on cardiovascular anatomy and function and CAM.

Methods: CINAHL, Cochrane Library, Scopus, Science Direct, PubMed, and Web of Science databases were searched. Outcomes were grouped into cardiovascular anatomic, functional, and autonomic alterations, and vascular remodeling. Studies were categorized as Spaceflight (SF), Chronic Simulation (CS), or Acute Simulation (AS) based on the weightlessness conditions. Meta-analysis was performed for the most frequent outcomes. Weightlessness and control groups were compared.

Results: 62 articles were included with a total of 963 participants involved. The meta-analysis showed that heart rate increased in SF [Mean difference (MD) = 3.44; p = 0.01] and in CS (MD = 4.98; p < 0.0001), whereas cardiac output and stroke volume decreased in CS (MD = −0.49; p = 0.03; and MD = −12.95; p < 0.0001, respectively), and systolic arterial pressure decreased in AS (MD = -5.20; p = 0.03). According to the qualitative synthesis, jugular vein cross-sectional area (CSA) and volume were greater in all conditions, and SF had increased carotid artery CSA. Heart rate variability and baroreflex sensitivity, in general, decreased in SF and CS, whereas both increased in AS.

Conclusion: This review indicates that weightlessness impairs the health of astronauts during and after spaceflight, similarly to the effects of aging and immobility, potentially increasing the risk of cardiovascular diseases.

Systematic Review Registration:https://www.crd.york.ac.uk/prospero/, identifier CRD42020215515.
Zeolite application and irrigation during ripening reduced berry sunburn damage and yield loss in cv. Sangiovese (Vitis vinifera L.)
Authors: Allegro Gianluca , Valentini Gabriele , Sangiorgio Daniela , Pastore Chiara , Filippetti Ilaria
Published: July 2024

Climate change poses significant challenges to the grapevine cultivation for wine production. In the last years, the occurrence of extreme weather events such as intense heat waves and prolonged period of drought increased sunburn damage with negative consequences to yield and berry composition. Short-term adaptation strategies are urgently needed to mitigate these effects. In this light, our study aimed to evaluate the efficacy of zeolite application on the canopy and irrigation during ripening on sunburn damage, yield, and berry composition in cv. Sangiovese (Vitis vinifera L.). Over 3 years (2021–2023), canopy management and irrigation treatments were arranged in a strip-plot design. Canopy management treatments included leaf removal on the cluster zone, with and without zeolite application, and no defoliated control; irrigation treatments comprised irrigation from berry softening and no irrigation. Both zeolite application and irrigation reduced sunburn damage, thus mitigating yield loss. Regarding berry composition, zeolite application did not alter the main parameters whereas irrigation led to reductions in sugar and anthocyanin concentrations. These findings suggest that zeolite application and irrigation during ripening represent promising and cost-effective solutions for grape growers facing climate change-induced challenges. However, further studies are necessary to optimize timing of irrigation to avoid detrimental effects on anthocyanin accumulation.
Specific learning disabilities and associated emotional-motivational profiles: a study in Italian university students
Authors: Iaia Marika , Vizzi Francesca , Carlino Maria Diletta , Turi Marco , Marinelli Chiara Valeria , Angelelli Paola
Published: July 2024

In this study, we analyzed the emotional and motivational aspects characterizing the profile of university students with Specific Learning Disorders (SLD). We assessed 61 university students, 32 with SLD (age = 23.6) and 29 in the control group (age = 23.00). The results highlighted that individuals with SLD exhibit higher levels of anxiety and depression and lower resilience compared to the control group. The Multidimensional Perfectionism Scale – Short Form, which explores perfectionism, did not reveal differences between the groups. Conversely, lower scores emerged in SLD students for the intrinsic motivation sub-scales of the Academic Motivation Scale. This indicates less engagement in studying out of personal cognitive curiosity. The Self-Regulated Knowledge Scale – University, which measures various cognitive strategies, showed significantly lower scores in the SLD group for knowledge linking, knowledge training, and knowledge critique. This suggests a lower frequency with which SLD students attempt to connect new knowledge with what they already possess, apply their knowledge, ask questions, and critically analyze what they have learned. Therefore, psychological and motivational consequences are evident in this population and can impact well-being and quality of life.
Factors influencing the generation of teachers’ emotions
Authors: Lai Lihua , Shi Wenjiang , Xie Yi , Zhao Jin
Published: July 2024

Background and aim

The teaching profession plays an important role in shaping individuals’ lives, with teachers performing complex emotional labour. The management of emotions is an integral part of teachers’ professional work, and it is essential to clarify their emotional experiences and the generating of their emotions within a specific cultural context.

Methods

Based on a phenomenological approach and the use of anecdotal texts, this study examined six common emotional states among teachers, including happiness, guilt, worry, fear, annoyance, and anger, along with the emotional experiences of two specialised categories of teachers, class supervisors, and pre-service teachers. The factors influencing teachers’ emotions and their generative mechanisms were analysed.

Results and discussion

This investigation found that key influences on teachers’ emotions stem from factors within the teachers’ themselves, the contextual nature of their work, and sociocultural dynamics. Drawing on the analytical frameworks of emotional geography theory, ecological theory of human development, and the ecosystem model of teachers’ emotional interactions, the study constructs a model highlighting the generative mechanisms of teachers’ emotions, and in which three systems are reflected.

Conclusion

Teachers’ personal attributes are in the direct area of the model and directly govern the formation of their emotions, while their work context consists of a transitional area in emotion formation and the sociocultural system acts as the latent band influencing emotion development. The mechanism model helps us to understand and recognise teachers’ emotions and to explore their pedagogical implications.
Variations in positive well-being as a function of the interaction between paranormal belief and schizotypy
Authors: Dagnall Neil , Drinkwater Kenneth Graham , Denovan Andrew , Gascón Alex Escolá
Published: July 2024

This study examined variations in positive well-being as a function of paranormal belief and schizotypy. A sample of 2,362 United Kingdom-based respondents completed self-report measures assessing paranormal belief, schizotypy, positive well-being (meaning in life, satisfaction with life, and self-esteem), paranormal experience, and belief in conspiracies. The paranormal belief was most strongly related to the cognitive–perceptual factor of schizotypy. Both paranormal belief and the cognitive–perceptual factor were associated with reporting paranormal experiences and endorsement of conspiracist beliefs. Despite commonality, paranormal belief and schizotypy were differentially related to well-being. Paranormal belief correlated positively with meaning in life (presence and search) and satisfaction with life. Schizotypy correlated negatively with presence, satisfaction with life, and self-esteem and positively with search. Latent profile analysis identified four subgroups: Profile 1, low belief and schizotypy (49% of the sample); Profile 2, low belief and cognitive–perceptual, moderate interpersonal and disorganised (13.6%); Profile 3, high belief, moderate cognitive–perceptual and interpersonal, low disorganised (24.3%); and Profile 4, high belief and schizotypy (13.1%). Multivariate analysis of variance (MANOVA) found that low belief with mixed schizotypy was associated with lower presence, and low belief and schizotypy (vs. high) were related to higher presence. Paranormal belief and schizotypy were associated with greater search, higher scores on paranormal experiential factors, and endorsement of generic conspiracist beliefs. Finally, lower belief and schizotypy were concomitant with higher satisfaction with life and self-esteem. Overall, paranormal belief was related to positive well-being, whereas schizotypy was associated with lower positive wellbeing.
How do students of different self-efficacy regulate learning in collaborative design activities? An epistemic network analysis approach
Authors: Chen Peng , Yang Dong , Lavonen Jari , Metwally Ahmed Hosny Saleh , Tang Xin
Published: July 2024

Introduction

Students' self-regulation skills and self-efficacy are linked to performance and are considered essential for lifelong learning. Understanding these skills and their development is crucial for educational success and long-term personal growth.

Methods

In this study, 60 students attending a university-level collaborative design course were recruited as participants. They were initially classified into three groups [high, mixed, and low self-efficacy (SE)] based on the initial test results. Students' written reflections were then analyzed using epistemic network analysis (ENA), aiming to explore the characteristics and developmental trajectories of self-regulated learning (SRL).

Results

Comparing with the other two groups, the high self-efficacy (HSE) group demonstrated: (1) more behavioral characteristics of SRL in the performance and self-reflection stages, (2) an earlier development of interest 91 in the task and recognition of its value during collaborative design activities, 92 followed by the utilization of more cognitive and metacognitive strategies; and (3) an “anticipation-behavior-reflection” loop in the self-regulation process.

Discussion

These findings highlight the importance of fostering high self-efficacy among students to enhance their self-regulated learning capabilities and overall academic performance. Strategies for improving learners' SRL and future research directions were provided accordingly.
Dreaming of being chased reflects waking-life experiences related to negative relationships with others metaphorically
Authors: Wang Jiaxi , Feng Xiaoling
Published: July 2024

Introduction

It has long been argued that there are dream metaphors which express waking-life experiences indirectly. Most of empirical evidence concerning this topic was in a qualitative way, while few studies explored the topic in a quantitative way. Under this background, we investigated whether dreaming of the typical theme ‘being chased or pursued’ was a metaphorical expression for waking-life experiences related to ‘negative relationships with others’.

Methods

One hundred and sixty participants reported their waking-life experiences and dreams for a single day. Following this, two external judges rated whether there were any elements related to ‘negative relationships with others’ in both waking-life experiences and dreams. In addition, the judges assessed if there was any content related to ‘being chased or pursued’ in both waking-life experiences and dreams.

Results

The frequency of dreaming of ‘negative relationships with others’ was higher than the frequency of the same topic in waking-life experiences, which in turn was higher than the frequency of typical theme dreaming of ‘being chased or pursued’. In addition, ‘negative relationships with others’ in waking-life experiences were correlated with both dreaming of ‘being chased or pursued’, and ‘negative relationships with others’ in dreams.

Conclusion

These results suggested that the typical theme ‘being chased or pursued’ in dreams may represent some waking-life experiences metaphorically. In addition, the results support the threat simulation theory of dreaming, which suggests that threatening events in waking life increase the possibility of threatening events in dreams.
Influence of coping with stressful situations on changes in aerobic capacity and post-workout restitution coefficient in the period of immediate preparation for the European men’s cadet wrestling championship
Authors: Jalowska Pola , Sokołowski Marek , Prokopczyk Adam
Published: July 2024

Aim of the study

The research goal of the study was to determine the relationship between coping with stressful situations and the level of aerobic capacity and post-workout restitution, as well as the changes that occur between these variables through the period of training camp preceding international men’s championship competitions in age cadet. Two research hypotheses were verified. The athletes will maintain or improve the results obtained in the performance test and the post-workout restitution coefficient during the immediate preparation period for the European Championships (H1), and the style of coping with stressful situations significantly affects changes in aerobic capacity and the post-workout restitution coefficient during the immediate preparation period for the European Championships (H2).

Materials and methods

The athletes of the National Men’s Team of Poland in classical style wrestling (n = 16). Coping with stressful situations was examined using the Coping Inventory for Stressful Situations (CISS). Aerobic capacity was analyzed using the Maximal Multistage 20-m Shuttle Run Test. The level of post-exercise restitution was calculated using the Klonowicz coefficient of restitution.

Results

There was a significant increase in aerobic capacity levels (p < 0.001), a decrease in resting HR (p < 0.002), HR 1′ after the test (p < 0.0031), and HR 5′ after the test (p < 0.007). There was a significant correlation between emotional coping style and avoidant style focused on looking for social contacts vs. HR 3′ after the test and (r = 0.60; p < 0.015) and HR 5′ after the test (r = 0.57; p < 0.020). In addition, a correlation was noted between avoidant style and maximum aerobic speed (r = −0.64; p < 0.008), and avoidant style focused on substitute activities vs. distance and maximum aerobic speed (r = −0.72; p < 0.002).

Conclusion

It is reasonable to implement psychological training and regular monitoring of mental preparation in the national men’s team training program for athletes competing in wrestling.
Psychometric properties of the Persian short form of the Stigma of Suicide Scale
Authors: Jafari Alireza , Mokhtari Ali Mohammad , Moshki Mahdi , Rahmani Fatemeh , Naddafi Fatemehzahra , Nejatian Mahbobeh
Published: July 2024

Objective

Suicide stigma is a major obstacle to suicide prevention, resulting in a decrease in mental help seeking. This study aimed to survey the psychometric characteristics of the Persian short form of the Stigma of Suicide Scale (SOSS).

Methods

This psychometric study was conducted on 956 people (EFA = 399 samples, CFA = 557) in 2022 to evaluate the validity (face, content, and structure validity) and reliability (Cronbach’s alpha coefficient, McDonald Omega coefficient, and intraclass correlation coefficient) of the SOSS. The structural validity of the scale was assessed by confirmatory factor analysis (CFA) and exploratory factor analysis (EFA).

Results

The scores of S-CVI/Ave and CVR for SOSS were 0.982 and 0.921, respectively. In the EFA section, three factors with eigenvalues above one were shown, and 60.60% variance of the scale was explained by these factors, and one question was eliminated due the factor loading less than 0.4 and also moving to an irrelevant factor. Finally, based on the goodness-of-fit indices (such as RMSEA = .077, CFI= .902, IFI= .903, GFI= .915), the Persian short form of SOSS was approved with 15 items and three factors of Glorification/Normalization (4 items), Stigma (7 items), Isolation/Depression (4 items). The McDonald Omega coefficient, Cronbach’s alpha coefficient, and ICC for SOSS were 0.841, 0.834, and 0.881, respectively.

Conclusion

In this study, the Persian short form of the SOSS was approved with 15 items and 3 factors, and this scale is an appropriate instrument for determining the status of suicide stigma among general population.
Association of perceived neighborhood air quality problems with attempt to quit cigarette smoking: a cross-sectional study in Texas
Authors: Chandra Monalisa , Fokom Domgue Joel , Yu Robert , Shete Sanjay
Published: July 2024

Background

Cigarette smoking is the major preventable cause of premature deaths in the United States. Attempting to quit smoking is an important step toward smoking cessation. Although it has been studied extensively, limited information on the association between attempts to quit smoking and neighborhood air quality problems is available. Therefore, we examined the association between attempts to quit smoking in the past year and perceived neighborhood air quality problems among adult Texans who smoke.

Methods

In 2018, a cross-sectional multistage area probability design-based survey was administered to collect sociodemographic, behavioral, and health-related information from a representative sample of 2050 Texas residents. The current study included 486 adult respondents who reported smoking within the past 12 months. The association between attempts to quit smoking and perceived neighborhood air quality (measured by self-reported problems with neighborhood air quality) was examined using a population-weighted multivariable logistic regression analysis.

Results

Overall, 60.7% of the 486 respondents attempted to quit cigarette smoking. The prevalence of attempting to quit was 74.6% for those reporting perceived neighborhood air quality problems. In the multivariable analysis, a higher likelihood of attempting to quit smoking was found among individuals with perceived neighborhood air quality problems (AOR: 1.906 [1.104–3.289]) and those who were married or living as married (AOR: 1.876 [1.161–3.033]). The likelihood of attempts to quit smoking was lower among males (AOR: 0.629 [0.397–0.995]) and decreased with age (AOR: 0.968 [0.951–0.984]).

Discussion

The perceived neighborhood air quality problems were found to independently predict attempts to quit cigarette smoking in Texas. To encourage quitting smoking among individuals living in neighborhoods with poor air quality, such neighborhoods should receive tailored and evidence-based interventions to improve community education, social support, and healthcare professionals’ assistance to quit smoking.
Evaluating enrollment and representation in COVID-19 and HIV vaccine clinical trials
Authors: Lezo Ramirez Daisy , Koleske Emily , Ometoruwa Omolola , Park Chang Jun Bai , Kanwal Urwah , Morreale Nicholas , Avila Paz Andres Alberto , Tong Alexandra , Baden Lindsey R. , Sherman Amy C. , Walsh Stephen R.
Published: July 2024

Background

Vaccine clinical trials should strive to recruit a racially, socioeconomically, and ethnically diverse range of participants to ensure appropriate representation that matches population characteristics. Yet, full inclusion in research is often limited.

Methods

A single-center retrospective study was conducted of adults enrolled at Brigham and Women’s Hospital (Boston, MA) between July 2020 and December 2021. Demographic characteristics, including age, race, ethnicity, ZIP code, and sex assigned at birth, were analyzed from both HIV and COVID-19 vaccine trials during the study period, acknowledging the limitations to representation under these parameters. We compared the educational attainment of vaccine trial participants to residents of the Massachusetts metropolitan area, geocoded participants’ addresses to their census block group, and linked them to reported median household income levels from publicly available data for 2020. Frequency and quartile analyses were carried out, and spatial analyses were performed using ArcGIS Online web-based mapping software (Esri).

Results

A total of 1030 participants from four COVID-19 vaccine trials (n = 916 participants) and six HIV vaccine trials (n = 114 participants) were included in the analysis. The median age was 49 years (IQR 33–63) and 28 years (IQR 24–34) for the COVID-19 and HIV vaccine trials, respectively. Participants identifying as White were the majority group represented for both the COVID-19 (n = 598, 65.3%) and HIV vaccine trials (n = 83, 72.8%). Fewer than 25% of participants identified as Hispanic or Latin. Based on ZIP code of residence, the median household income for COVID-19 vaccine clinical trial participants (n = 846) was 102,088 USD (IQR = 81,442–126,094). For HIV vaccine clinical trial participants (n = 109), the median household income was 101,266 USD (IQR 75,052–108,832).

Conclusion

We described the characteristics of participants enrolled for HIV and COVID-19 vaccine trials at a single center and found similitude in geographical distribution, median incomes, and proportion of underrepresented individuals between the two types of vaccine candidate trials. Further outreach efforts are needed to ensure the inclusion of individuals from lower educational and socioeconomic brackets. In addition, continued and sustained efforts are necessary to ensure inclusion of individuals from diverse racial and ethnic backgrounds.
COVID-19 prevention and control effect of non-pharmaceutical interventions—fuzzy-sets qualitative comparative analysis based on 69 countries in the world
Authors: Yang Chunxiao , Li Qiusha , Zhao Zixuan , Chen Zhongming , Guo Hongwei , Huang Dongmei , Yin Wenqiang
Published: July 2024

Introduction

Coronavirus disease 2019 occurred unexpectedly in late December 2019, it was difficult to immediately develop an effective vaccine or propose targeted medical interventions in the early stages of the outbreak. At this point, non-pharmaceutical interventions (NPIs) are essential components of the public health response to COVID-19. How to combine different NPIs in the early stages of an outbreak to control the spread of epidemics and ensure that the policy combination does not incur high socio-economic costs became the focus of this study.

Methods

We mainly used the fuzzy set qualitative comparative analysis to assess the impact of different combinations of NPIs on the effectiveness of control in the COVID-19 pandemic early stage, using open datasets containing case numbers, country populations and policy responses.

Results

We showed that the configuration of high morbidity results includes one, which is the combination of non-strict face covering, social isolation and travel restrictions. The configuration of non-high morbidity results includes three, one is strict mask wearing measures, which alone constitute sufficient conditions for interpreting the results; the second is strict testing and contact tracing, social isolation; the third is strict testing and contact tracing, travel restriction. The results of the robustness test showed that the number, components and consistency of the configurations have not changed after changing the minimum case frequency, which proved that the analysis results are reliable.

Conclusion

In the early stages of the epidemic, the causes of high morbidity are not symmetrical with the causes of non-high morbidity. Strict face covering is the most basic measure required to prevent and control epidemics, and the combination of non-strict face covering and containment is the most important factor leading to poor prevention and control, and the combination of strict containment and proactive pursuit is the way to achieve superior prevention and control, timely and proactive containment strategies have better prevention and control, and should mobilize the public to cooperate.
Immersive insights: evaluating augmented reality interfaces for pedestrians in a CAVE-based experiment
Authors: Tabone Wilbert , Happee Riender , Yang Yue , Sadraei Ehsan , García de Pedro Jorge , Lee Yee Mun , Merat Natasha , de Winter Joost
Published: July 2024

Introduction: Augmented reality (AR) has been increasingly studied in transportation, particularly for drivers and pedestrians interacting with automated vehicles (AVs). Previous research evaluated AR interfaces using online video-based questionnaires but lacked human-subject research in immersive environments. This study examined if prior online evaluations of nine AR interfaces could be replicated in an immersive virtual environment and if AR interface effectiveness depends on pedestrian attention allocation.

Methods: Thirty participants completed 120 trials in a CAVE-based simulator with yielding and non-yielding AVs, rating the interface’s intuitiveness and crossing the road when they felt safe. To emulate visual distraction, participants had to look into an attention-attractor circle that disappeared 1 s after the interface appeared.

Results: The results showed that intuitiveness ratings from the current CAVE-based study and the previous online study correlated strongly (r ≈ 0.90). Head-locked interfaces and familiar designs (augmented traffic lights, zebra crossing) yielded higher intuitiveness ratings and quicker crossing initiations than vehicle-locked interfaces. Vehicle-locked interfaces were less effective when the attention-attractor was on the environment’s opposite side, while head-locked interfaces were relatively unaffected by attention-attractor position.

Discussion: In conclusion, this ‘AR in VR’ study shows strong congruence between intuitiveness ratings in a CAVE-based study and online research, and demonstrates the importance of interface placement in relation to user gaze direction.
On the correlation between the enantiomeric excess of L-isovaline and the level of aqueous alteration in carbonaceous meteorites
Authors: Avnir David
Published: July 2024

A positive correlation was observed between the enantiomeric excess (ee) of L-isovaline (L-iVal) and the degree of aqueous alteration (AqA) of carbonaceous meteorites. The origin of this remarkable phenomenon has remained enigmatic from two points of view: First, the correlation is between seemingly unrelated observables–nothing about AqA is of chiral characteristics; and second, following the accepted assumption that circularly polarized light (CPL) was the origin of the observed meteoritic ee of L-amino acids (AAs), it remined unclear why some of the observed levels of the ee of L-iVal in that correlation are significantly higher than those observed in laboratory simulations or those obtained from circular dichroism (CD) g-factor calculations. The current proposition accounting for this picture attributes late AqA conditions of the meteoritic parent bodies as providing the grounds for amplification of early initially CPL-generated low levels of L-ee. For reasons summarized below, this interpretation, which treats the CPL event and the AqA process as occurring in wide-time separated eras, is re-visited. An alternative interpretation of the observed correlation and of the high ee-values, is provided. It focuses on hydrophilic dust-aggregates clouds in wet star-forming regions in early pre-solar times, where both the CPL event and the grounds leading to the later AqA processes of the parent bodies, occurred. This mechanism removes the time separation between the initial ee formation and the AqA of the parent body, and replaces it with parallel processes, providing a scenario to the observation of high ee’s without total destruction, and to the apparent AqA/L-ee correlation. Although iVal is at the focus of this report, the steps of the development of the alternative mechanism and the conclusions that arise from it, are relevant and applicable to the general observations of L-ee’s of meteoritic AA’s.
The law code of ChatGPT and artificial intelligence—how to shield plastic surgeons and reconstructive surgeons against Justitia's sword
Authors: Knoedler Leonard , Vogt Alexander , Alfertshofer Michael , Camacho Justin M. , Najafali Daniel , Kehrer Andreas , Prantl Lukas , Iske Jasper , Dean Jillian , Hoefer Simon , Knoedler Christoph , Knoedler Samuel
Published: July 2024

Large Language Models (LLMs) like ChatGPT 4 (OpenAI), Claude 2 (Anthropic), and Llama 2 (Meta AI) have emerged as novel technologies to integrate artificial intelligence (AI) into everyday work. LLMs in particular, and AI in general, carry infinite potential to streamline clinical workflows, outsource resource-intensive tasks, and disburden the healthcare system. While a plethora of trials is elucidating the untapped capabilities of this technology, the sheer pace of scientific progress also takes its toll. Legal guidelines hold a key role in regulating upcoming technologies, safeguarding patients, and determining individual and institutional liabilities. To date, there is a paucity of research work delineating the legal regulations of Language Models and AI for clinical scenarios in plastic and reconstructive surgery. This knowledge gap poses the risk of lawsuits and penalties against plastic surgeons. Thus, we aim to provide the first overview of legal guidelines and pitfalls of LLMs and AI for plastic surgeons. Our analysis encompasses models like ChatGPT, Claude 2, and Llama 2, among others, regardless of their closed or open-source nature. Ultimately, this line of research may help clarify the legal responsibilities of plastic surgeons and seamlessly integrate such cutting-edge technologies into the field of PRS.
Exploring the dynamics of Programmed Death-Ligand 1 in canine lymphoma: unraveling mRNA amount, surface membrane expression and plasmatic levels
Authors: Ubiali Alessandra , Cesar Conti Luiza , Dall’Ara Paola , De Maria Raffaella , Aresu Luca , Moretti Pierangelo , Sini Federica , Riondato Fulvio , Stefanello Damiano , Comazzi Stefano , Martini Valeria
Published: July 2024

Introduction

Programmed Death-Ligand 1 is a well-known immune checkpoint molecule. Recent studies evaluated its expression in different canine cancer types through different laboratory techniques. The present study aims to evaluate the surface membrane protein expression (mPD-L1) by means of flow cytometry (FC) in different canine lymphoma immunophenotypes. Furthermore, in a subset of cases, mRNA and plasmatic soluble protein (sPD-L1) have been assessed in the same patient, and correlations among results from the three analyses investigated.

Methods

Samples obtained for diagnostic purpose from untreated dogs with a confirmed lymphoma immunophenotype were included: surface protein was assessed via FC and quantified with median fluorescence index ratio (MFI ratio), gene expression was evaluated by real time quantitative polymerase chain reaction (RT-qPCR) and plasmatic concentration of soluble protein (sPD-L1) measured with ELISA. Statistical analyses were performed to investigate any difference among FC immunophenotypes, updated Kiel cytological classes, and in the presence of blood infiltration.

Results

Considering FC, most B-cell lymphomas (BCL) were positive, with higher MFI ratios than other subtypes (81%, median MFI ratio among positive samples = 1.50, IQR 1.21–2.03, range 1.01–3.47). Aggressive T-cell lymphomas had a lower percentage of positive samples (56%) and showed low expression (median MFI ratio in positive samples = 1.14, IQR 1.07–1.32, range 1.02–2.19), while T-zone lymphomas (TZL) were frequently positive (80%) but with low expression (median MFI ratio in positive samples = 1.19, IQR 1.03–1.46, range 1.02–6.03). Cellular transcript and sPD-L1 were detected in all samples, without differences among immunophenotypes. No correlation between results from different techniques was detected, but sPD-L1 resulted significantly increased in FC-negative lymphomas (p = 0.023).

Discussion

PD-L1 molecule is involved in canine lymphoma pathogenesis, with differences among immunophenotypes detected by FC. Specifically, BCL have the highest expression and aggressive T-cell lymphomas the lowest, whereas TZL need further investigations.
Bacillus spp. as potential probiotics: promoting piglet growth by improving intestinal health
Authors: Tang Xiaopeng , Zeng Yan , Xiong Kangning , Zhong Jinfeng
Published: July 2024

The application of Bacillus spp. as probiotics in the swine industry, particularly for piglet production, has garnered significant attention in recent years. This review aimed to summarized the role and mechanisms of Bacillus spp. in promoting growth and maintaining gut health in piglets. Bacillus spp. can enhance intestinal barrier function by promoting the proliferation and repair of intestinal epithelial cells and increasing mucosal barrier integrity, thereby reducing the risk of pathogenic microbial invasion. Additionally, Bacillus spp. can activate the intestinal immune system of piglets, thereby enhancing the body’s resistance to diseases. Moreover, Bacillus spp. can optimize the gut microbial community structure, enhance the activity of beneficial bacteria such as Lactobacillus, and inhibit the growth of harmful bacteria such as Escherichia coli, ultimately promoting piglet growth performance and improving feed efficiency. Bacillus spp. has advantages as well as challenges as an animal probiotic, and safety evaluation should be conducted when using the newly isolated Bacillus spp. This review provides a scientific basis for the application of Bacillus spp. in modern piglet production, highlighting their potential in improving the efficiency of livestock production and animal welfare.
The Ecology of Economic Distress and Life Expectancy
Authors: Weeks William Brinson , Chang Ji E. , Pagán José A. , Adamson Elizabeth , Weinstein James , Ferres Juan M. Lavista
Published: July 2024

Objectives

To determine whether life expectancy (LE) changes between 2000 and 2019 were associated with race, rural status, local economic prosperity, and changes in local economic prosperity, at the county level.

Methods

Between 12/1/22 and 2/28/23, we conducted a retrospective analysis of 2000 and 2019 data from 3,123 United States counties. For Total, White, and Black populations, we compared LE changes for counties across the rural-urban continuum, the local economic prosperity continuum, and for counties in which local economic prosperity dramatically improved or declined.

Results

In both years, overall, across the rural-urban continuum, and for all studied populations, LE decreased with each progression from the most to least prosperous quintile (all p < 0.001); improving county prosperity between 2000–2019 was associated with greater LE gains (p < 0.001 for all).

Conclusion

At the county level, race, rurality, and local economic distress were all associated with LE; improvements in local economic conditions were associated with accelerated LE. Policymakers should appreciate the health externalities of investing in areas experiencing poor economic prosperity if their goal is to improve population health.
Donor Evaluation Tool: A New Technology Improves Donor Enrolment on ICU
Authors: Imbimbo Chiara , Nauwerk Marcus , Cammarota Tizian , Beyeler Franziska , Krügel Nathalie , Elmer Andreas , Mueller Thomas F. , Immer Franz
Published: July 2024

Uncertainties on the intensive care unit (ICU) regarding the eligibility of a patient to be a potential deceased organ donor may prevent their referral and enrolment in the pathway for organ donation. Healthcare staff may exclude potential donors for medical reasons, which are no longer applicable. Hence, Swisstransplant implemented a digital donor evaluation tool (DET) in 2021, which allows the local hospital’s organ donation coordinator to send a direct request to medical advisors (MA) of the organ procurement organization before excluding potential donors. All 156 requests entered in 2022 were analyzed. 117 patients (75.0%) were primarily accepted by the MA as potential donors. Of those 60 patients (51.3%) became actual organ donors. Main reasons for using the DET were questions regarding malignancies (n = 33, 21.2%), infectious diseases (n = 35, 22.4%) and age/co-morbidities (n = 34, 21.8%). The average age of the actual “DET donor” compared to the regularly enrolled, actual “Non-DET donor” was 65.3 ± 15.8 vs. 56.8 ± 17.5 years, respectively (p = 0.008). On average 1.9 ± 1.1 organs compared to 3.2 ± 1.3 organs were retrieved from DET vs. Non-DET donors. In summary, this new digital donor evaluation tool supports reporting and facilitates eligibility decisions in uncertain, complex donor cases, potentially increasing the number of organ donations.
Double Air Chambers Pneumatic Artificial Muscle and Non-Hysteresis Position Control
Authors: Saito Naoki , Satoh Toshiyuki , Saga Norihiko
Published: July 2024

In this paper, we propose a double air chambers artificial muscle to eliminate the hysteresis in the extension and contraction movement of pneumatic artificial muscles. In this paper, the basic structure of the double air chambers artificial muscle is a rubberless artificial muscle with a particularly large hysteresis loop. The double air chambers artificial muscle aims to eliminate hysteresis by directly pressurizing the inside and outside of the air chamber and actively deforming the air chamber. The hysteresis is reduced by the pressure outside of the air chamber (external pressure). Since the appropriate external pressure varies depending on the contraction force and amount of contraction, we proposed a method to regulate the appropriate external pressure by feedback control. The experimental results show that hysteresis was eliminated in the static characteristics. It was also found that the output gain decreased, and the phase lag increased as the target frequency increased. The output gain did not change with increasing load. The phase lag tended to improve with the PID controller compared to the PI controller. These results suggest that the combination of double air chambers artificial muscle and external pressure-regulated feedback control can achieve non-hysteresis position control, and it is useful as an actuator in mechatronic systems.
A Disturbance Sliding Mode Observer Designed for Enhancing the LQR Current-Control Scheme of a Permanent Magnet Synchronous Motor
Authors: Zhang Zhidong , Yang Gongliu , Fan Jing , Li Tao , Cai Qingzhong
Published: July 2024

This paper introduces a current control method for permanent magnet synchronous motors (PMSMs) using a disturbance sliding mode observer (DSMO) in conjunction with a linear quadratic regulator (LQR). This approach enhances control performance, streamlines the tuning of controller parameters, and offers robust optimal control that is resistant to system disturbances. The LQR controller based on state feedback is advantageous for its simplicity in parameter adjustment and achieving an optimal control effect easily under specific performance indicators. It is suitable for the optimal control of strong linear systems that can be accurately modeled. However, most practical systems are difficult to model accurately, and the time-varying system parameters and existing nonlinearity limit the engineering application of LQR. In the PMSM current control loop, there is strong nonlinear disturbance manifesting as the nonlinearity of its dynamic model. Additionally, substantial noise and variations in system parameters within actual motor circuits hinder the linear quadratic regulator from attaining optimal performance. A disturbance sliding mode observer is proposed to enhance the LQR controller, enabling superior performance in nonlinear current loop control. Simulation and actual hardware experiments were conducted to verify the performance and robustness of the control scheme proposed in this paper. Compared with the widely used PI controller in engineering and sliding mode control (SMC) specialising in disturbance rejection, it offers the advantage of straightforward parameter tuning and can swiftly achieve the robust and optimal control performance that engineers prioritize.
Leader-Following Connectivity Preservation and Collision Avoidance Control for Multiple Spacecraft with Bounded Actuation
Authors: Xue Xianghong , Wang Xin , Han Nannan
Published: July 2024

This paper investigates the distributed formation control of a group of leader-following spacecraft with bounded actuation and limited communication ranges. In particular, connectivity-preserving and collision-avoidance controllers are proposed for the leader with constant or time-varying velocity, respectively. The communication graph between the spacecraft is modeled via a distance-induced proximity graph. By designing a virtual proxy for each spacecraft, the spacecraft–proxy couplings address the actuator saturation constraints. The inter-proxy dynamics incorporated with a bounded artificial potential function fulfill the coordination of all proxies. In addition, the bounded potential function can simultaneously tackle connectivity preservation and collision avoidance problems. The distributed formation controllers are proposed for multiple spacecraft with constant or time-varying velocities relative to the leader. A sliding mode control approach and the proxies’ dynamics are used in the design of a distributed cooperative controller for spacecraft to address the cooperative problem between the followers and the leader. Numerical simulations confirm the effectiveness of the anti-saturation distributed connectivity preservation controller.
Recent Advances in 3D Object Detection for Self-Driving Vehicles: A Survey
Authors: Fawole Oluwajuwon A. , Rawat Danda B.
Published: July 2024

The development of self-driving or autonomous vehicles has led to significant advancements in 3D object detection technologies, which are critical for the safety and efficiency of autonomous driving. Despite recent advances, several challenges remain in sensor integration, handling sparse and noisy data, and ensuring reliable performance across diverse environmental conditions. This paper comprehensively surveys state-of-the-art 3D object detection techniques for autonomous vehicles, emphasizing the importance of multi-sensor fusion techniques and advanced deep learning models. Furthermore, we present key areas for future research, including enhancing sensor fusion algorithms, improving computational efficiency, and addressing ethical, security, and privacy concerns. The integration of these technologies into real-world applications for autonomous driving is presented by highlighting potential benefits and limitations. We also present a side-by-side comparison of different techniques in a tabular form. Through a comprehensive review, this paper aims to provide insights into the future directions of 3D object detection and its impact on the evolution of autonomous driving.
Influence of Incubation Temperature and Relative Humidity on the Egg Hatchability Pattern of Two-Spotted (Gryllus bimaculatus) and House (Acheta domesticus) Crickets
Authors: Mitchaothai Jamlong , Lertpatarakomol Rachakris , Trairatapiwan Tassanee , Lukkananukool Achara
Published: July 2024

This study aimed to determine the influence and optimal conditions of incubation temperature and relative humidity (RH) on the egg hatchability patterns of two-spotted (Gryllus bimaculatus) and house (Acheta domesticus) crickets. Experiment I involved 100 cricket eggs per hatching box for each species, with six replications for each controlled incubation temperature of 23, 25, 27, 29, 30, 31, 32, and 33 °C at 70% RH. Experiment II used all the same procedures as Experiment I, except for incubation temperatures of 29, 30, 31, and 32 °C tested with varied RH levels of 65%, 70%, and 75%. In Experiment I, two-spotted crickets (9.47 ± 1.99 days) exhibited faster hatching than house crickets (13.70 ± 2.78 days). Additionally, the onset of hatching decreased with higher incubation temperatures for both types of crickets. In Experiment II, an incubation temperature of 31 °C and 70% RH resulted in a hatching rate of 79.75% for two-spotted crickets, with hatching beginning in 6 days. For house cricket eggs, the optimal conditions of 30 °C and 65–75% RH led to a peak daily hatching rate of 62.00–65.50% and hatching onset in 12 days. Thus, this study established the optimal incubation temperature and RH for egg hatching of two-spotted and house crickets.
Specificity of Key Sex Determination Genes in a Mammal with Ovotestes: The European Mole Talpa europaea
Authors: Bogdanov Alexey , Sokolova Maria , Bakloushinskaya Irina
Published: July 2024

Here, for the first time, the structure of genes involved in sex determination in mammals (full Sry and partial Rspo1, Eif2s3x, and Eif2s3y) was analyzed for the European mole Talpa europaea with ovotestes in females. We confirmed male-specificity for Eif2s3y and Sry. Five exons were revealed for Rspo1 and the deep similarity with the structure of this gene in T. occidentalis was proved. The most intriguing result was obtained for the Sry gene, which, in placental mammals, initiates male development. We described two exons for this canonically single-exon gene: the first (initial) exon is only 15 bp while the second exon includes 450 bp. The exons are divided by an extended intron of about 1894 bp, including the fragment of the LINE retroposon. Moreover, in chromatogram fragments, which correspond to intron and DNA areas, flanking both exons, we revealed double peaks, similar to heterozygous nucleotide sites of autosomal genes. This may indicate the existence of two or more copies of the Sry gene. Proof of copies requires an additional in-depth study. We hypothesize that unusual structure and possible supernumerary copies of Sry may be involved in ovotestes formation.
Particulate Matter Emissions at Different Microenvironments Using Low-Cost Sensors in Megacity Dhaka, Bangladesh
Authors: Nayeem Md. Asif Iqbal , Roy Shatabdi , Zaman Shahid Uz , Salam Abdus
Published: July 2024

The global challenge of air pollution’s adverse health effects, particularly highlighted in Dhaka, Bangladesh, underscores the significant impact of particulate matter (PM) exposure. This study aims to assess the current sources of PM2.5 emissions in different microenvironments around Dhaka and explore potential risk factors to assess individual 24 h exposure to PM2.5. A commercially available low-cost sensor was utilized for collecting data for 15 days under various environmental conditions. The average concentrations for PM1.0, PM2.5, and PM10 were 37.05 ± 24.36 µg/m3, 57.22 ± 40.75 µg/m3, and 69.22 ± 48.46 µg/m3, respectively. The highest PM2.5 concentrations were found (78.87 ± 53.69 μg/m3) in restaurants and residences (62.35 ± 41.70 μg/m3), while air-conditioned shopping malls exhibited the lowest concentrations (20.08 ± 15.57 μg/m3). Driving with windows closed and utilizing air conditioning resulted in a 33–52% reduction in PM2.5 concentrations inside the car. The Hazard Quotient (HQ) for PM2.5 varied by location, with a low level observed in the air-conditioned locations and a moderate level observed in restaurants and non-air-conditioned shopping malls. The significance of this study lies in its potential to inform public health strategies and urban planning initiatives aimed at reducing air pollution exposure in highly populated cities like Dhaka.