bluuebunny/crossref_metadata_2025 huggingface dataset:
Del sistema integrado de gestión al sistema de gestión integral: la gestión del conocimiento como estrategia en el Cuerpo Oficial de Bomberos de Bogotá
Authors: Becerra Olga Lucia Torres , Ladino Martha Mercedes Suna
Published: February 2016

En Colombia, desde la promulgación de la Ley 872 de 2003, “Por la cual se crea el sistema de gestión de la calidad en la Rama Ejecutiva del Poder Público y en otras entidades prestadoras de servicios”, se han implementado en las entidades del sector público sistemas de gestión, tales como el de calidad, el ambiental y el de la seguridad y salud ocupacional. Sin embargo, se evidencia un rechazo contra la implementación de estos sistemas de gestión por parte de los funcionarios, quienes obstaculizan su cabal funcionamiento afectando los procesos, las políticas e, incluso, a las personas de las entidades. 

integral debe trascender el sistema integrado de gestión, en razón a la xistencia de un eje articulador que permite la emergencia de restricciones para cada uno
de sus componentes, de tal forma que todos apunten a la cohesión del sistema y, por tanto, a su organización; esta premisa se constituye en el inicio de un proceso de cambio en el caso del Cuerpo Oficial de Bomberos de Bogotá, para migrar del sistema integrado de gestión a un sistema de gestión integral, articulándolo por medio del modelo de gestión del conocimiento que se
define en este trabajo.

El marco teórico se aboca fundamentalmente desde las tesis de Ikujiro Nonaka sobre la creación de conocimiento, de Antonio Leal Millán sobre almacenar
y recuperar el conocimiento, de Fernando Davara sobre transferir el conocimiento, y de Robert Grant sobre los mecanismos primarios para la aplicación del conocimiento. Igualmente, se aboca la gestión integral desde el paradigma sistémico de Edgar Morin.
Evaluación de las características de un sistema de información con base en la norma ISO/IEC 9126-1
Authors: Guío Ávila Henry Alfonso
Published: February 2016

Con el fin de evaluar la calidad de los sistemas de información aplicados por las organizaciones y buscar su mejoramiento, se han desarrollado normas técnicas internacionales.

El propósito de este estudio consiste en evaluar las características de calidad de un sistema de información en cuanto a su efectividad, productividad, seguridad y satisfacción, mediante el uso de la norma técnica ISO/IEC 9126-1:2001. La metodología de evaluación
se basa en la operación en uso de un sistema de información, según la metodología propuesta por la norma técnica ISO/IEC 9126-4:2004. Como contexto de aplicación para la evaluación se toma el sistema de información académico (SAC) que la Universidad anto Tomás – Seccional Tunja desarrolló en el marco de la construcción de su sistema de gestión de la calidad bajo el modelo ISO 9001:2008. El sistema de información académico SAC tiene un papel preponderante, ya que constituye el eje de los procesos académicos y administrativos de la Universidad.

Se identifican la conformidad o no del SAC con las características de calidad de software mencionadas anteriormente, así como la relación entre la evaluación y el sistema de gestión de la calidad. La investigación destaca el aporte al cumplimiento de los principios de gestión de la calidad, principalmente en lo referente al enfoque al cliente, la mejora continua y la toma de decisiones basada en hechos.
A Novel Test for Detecting SNP–SNP Interactions in Case-Only Trio Studies
Authors: Balliu Brunilda , Zaitlen Noah
Published: February 2016

Epistasis plays a significant role in the genetic architecture of many complex phenotypes in model organisms. To date, there have been very few interactions replicated in human studies due in part to the multiple-hypothesis burden implicit in genome-wide tests of epistasis. Therefore, it is of paramount importance to develop the most powerful tests possible for detecting interactions. In this work we develop a new SNP–SNP interaction test for use in case-only trio studies called the trio correlation (TC) test. The TC test computes the expected joint distribution of marker pairs in offspring conditional on parental genotypes. This distribution is then incorporated into a standard 1 d.f. correlation test of interaction. We show via extensive simulations under a variety of disease models that our test substantially outperforms existing tests of interaction in case-only trio studies. We also demonstrate a bias in a previous case-only trio interaction test and identify its origin. Finally, we show that a previously proposed permutation scheme in trio studies mitigates the known biases of case-only tests in the presence of population stratification. We conclude that the TC test shows improved power to identify interactions in existing, as well as emerging, trio association studies. The method is publicly available at www.github.com/BrunildaBalliu/TrioEpi.
Kel1p Mediates Yeast Cell Fusion Through a Fus2p- and Cdc42p-Dependent Mechanism
Authors: Smith Jean A , Rose Mark D
Published: February 2016

Cell fusion is ubiquitous among eukaryotes. Although little is known about the molecular mechanism, several proteins required for cell fusion in the yeast Saccharomyces cerevisiae have been identified. Fus2p, a key regulator of cell fusion, localizes to the shmoo tip in a highly regulated manner. C-terminal truncations of Fus2p cause mislocalization and fusion defects, which are suppressed by overexpression of Kel1p, a kelch-domain protein of unknown function previously implicated in cell fusion. We hypothesize that Fus2p mislocalization is caused by auto-inhibition, which is alleviated by Kel1p overexpression. Previous work showed that Fus2p localization is mediated by both Fus1p- and actin-dependent pathways. We show that the C-terminal mutations mainly affect the actin-dependent pathway. Suppression of the Fus2p localization defect by Kel1p is dependent upon Fus1p, showing that suppression does not bypass the normal pathway. Kel1p and a homolog, Kel2p, are required for efficient Fus2p localization, acting through the actin-dependent pathway. Although Kel1p overexpression can weakly suppress the mating defect of a FUS2 deletion, the magnitude of suppression is allele specific. Therefore, Kel1p augments, but does not bypass, Fus2p function. Fus2p mediates cell fusion by binding activated Cdc42p. Although Kel1p overexpression suppresses a Cdc42p mutant that is defective for Fus2p binding, cell fusion remains dependent upon Fus2p. These data suggest that Fus2p, Cdc42p, and Kel1p form a ternary complex, which is stabilized by Kel1p. Supporting this hypothesis, Kel1p interacts with two domains of Fus2p, partially dependent on Cdc42p. We conclude that Kel1p enhances the activity of Fus2p/Cdc42p in cell fusion.
Representing morphological tone in a computational grammar of Hausa
Authors: Crysmann Berthold
Published: February 2016

In this paper I shall discuss the representation of morphological tone in Hausa, as implemented in a computational grammar of the language, referred to as HaG, which has been developed within the framework of Head-driven Phrase Structure Grammar. Based on an in-depth study of segmental and suprasegmental properties manipulated by morphological processes, I shall argue that two fundamental insights from Autosegmental Phonology needs to be seamlessly integrated into typed feature structure grammars of languages with grammatical tone, namely (i) the systematic separation of tonal and metrical information from the string of consonants and vowels, and (ii) the possibility of tonal spreading, i.e. the possibility for a tonal specification to be assigned to an arbitrary number of adjacent tone-bearing units (syllables). To this end, I present a formalisation of tonal melodies in terms of typed list constraints that implement a notion of tonal spreading, allowing for an underspecified description of tonal melodies, independent of the number of tone-bearing units. I shall finally show that this minimal encoding is sufficient and flexible enough to capture the range of suprasegmental phenomena in Hausa.
Islamic Work Ethics and Audit Opinions: Audit Professionalism and Dysfunctional Behavior as Intervening Variables
Authors: Suryanto Tulus
Published: February 2016

This study examinesthe relationship between Islamic work ethics and auditors’ opinion, focusing onthe aspects of audit professionalism and dysfunctional behavior as interveningvariables. The research involved in Internal Auditors working of Islamic Bankingindustry in Sumatra Island. A questionnaire was used for data collection. Thestudy represents the empirical test employing census sampling. The data collectedwere analysed using Amos. The results of the study confirmed the three hypothesesexamined: there is a positive corelation between Islamic work ethics and auditors’opinions; auditors’ professionalism is an intervening variable of the correlationbetween Islamic work ethics and auditors’ opinions and dysfunctional behavioris a negative intervening variable of the correlation between Islamic Work Ethicsand auditors’ opinionsDOI: 10.15408/aiq.v8i1.2508
Dual Monetary System and Macroeconomic Performance in Indonesia
Authors: Herianingrum Sri , Syapriatama Imronjana
Published: February 2016

This research aims to evaluate the impact of dual monetary policyshock on macroeconomic indicators of Indonesia: growth and inflation. Inaddition, this study will also examine whether conventional monetary policy hasa particular impact upon Islamic banking sector. This research apply VAR (vectorauto regressive) method on monthly data from Bank Of Indonesia during theperiod of January 2010 to December 2013. The result of IRF explain that theinterest rate channel find the hard way to accomplished the macroeconomic goalswhile the Islamic monetary instrument indicates the potential growth of outputand hold the inflation low. The result of VDC describes that the Islamic instrumentstill affected by conventional monetary policy because of slow development inIslamic monetary systemDOI: 10.15408/aiq.v8i1.2509
Geophysical and Related Techniques Applied to Archaeological Survey in the Mediterranean: A Review
Authors: Sarris Apostolos , Jones Richard
Published: February 2016

During the last few years geophysical survey has developed considerably in terms of instrumentation and image processing. Together with remote sensing and GIS, it is becoming increasingly, if still slowly, integrated into archaeological investigations in the Mediterranean. This article reviews how, and with what success, geophysical techniques - and, to a lesser extent, geochemical methods, aerial/satellite remote sensing and GIS - have been applied to Mediterranean (especially Greek) archaeology, bearing in mind the environmental constraints of the region, and the significance, diversity and number of its ancient monuments. The application of all the main techniques of geophysical survey and some geochemical methods to a wide range of archaeological targets carried out over the last 40 years is discussed critically. Current developments in instrumentation and data processing are presented, and the next generation of geophysical work, which will have to meet challenges in relation to the protection and management of cultural resources, is also considered. In view of the need to create a common platform for the preservation of cultural heritage, it is argues that geophysical prospection techniques have to become an inseparable component of the archaeological investigation process.
Confinement strengthening of heat-damaged reinforced concrete columns
Authors: Roy Anasco Bastin Danie , Sharma Umesh Kumar , Bhargava Pradeep
Published: February 2016

The effectiveness of different strengthening techniques in restoring heat-damaged concrete short columns was evaluated experimentally. Four confinement strengthening systems were employed: high-strength fibre-reinforced concrete (HSFRC), ferrocement (FC), glass-fibre-reinforced polymer (GFRP) and steel plate (SP) jacketing. Fifty-one reinforced concrete prisms of size 150 × 150 × 450 mm were first subjected to different elevated temperatures. Heated specimens were strengthened using one of the chosen techniques. Thereafter, all specimens were tested under monotonic loading to determine the axial ultimate strength, stiffness, ductility, energy absorption and peak stress–strain behaviour. It was observed that the GFRP jacketing was effective in restoring the compressive strength and energy dissipation, but was not capable of restoring the stiffness. However, FC and HSFRC jacketing were effective mainly in restoring the stiffness of heat-damaged concrete. SP jacketing was not effective in improving the strength or the stiffness properties. GFRP jacketing was found to be the most effective method for strengthening of fire- or heat-damaged concrete structures.
Audit Procedures and Responsibilities on Audit Decisions: An Examination for Kenya
Authors: Chesoli Joshua W. , Long’acha Eliud Kerio
Published: February 2016

The purpose of this study is to examine how internal audit procedures and responsibility perceptions of the auditors impact the audit decisions of independent external auditors. The questions of the research are answered by the certified public accountants (CPA) operating in Turkey and the establishments that audit companies independently. The results of the study show that the procedural efficiency of internal auditors in auditing and their taking responsibility have a positive impact on the decisions of independent external auditors. Another result of the study was that in the absence of internal audit elements in the company or in the case that internal auditors do not function properly, the audit result of the independent auditor will be more ineffective. In this respect, in order to get objective and reliable data from the independent external auditors, internal procedures should be streamlined and internal auditors should be willing to cooperate with external auditors more.
Modele culturale de standardizare lingvistică
Authors: Geeraerts Dirk
Published: February 2016

În acord cu tendințele din teoria culturală (vezi Burke et al., 2000), lingvistica cognitivă evidențiază faptul că noi înțelegem realitatea socială prin prisma unor modele, „modele culturale” sau „teorii naive (populare)”, și, de la Holland & Quinn (1987) la Lakoff (1996) și Palmer (1998) pînă la Dirven et al. (2001a, 2001b), specialiștii în lingvistică cognitivă au demonstrat că instrumentarul tehnic al lingvisticii cognitive poate fi utilizat pentru a arăta că perspectivele noastre asupra realității sociale sînt modelate pe baza unor de tipare de gîndire. Însă, dacă limba este o realitate socială și culturală, ce modele ne formează concepția despre limbă? Mai exact, care sînt modelele care formează modul nostru de a gîndi despre limbă ca fenomen social? Care sînt paradigmele pe care le folosim pentru a gîndi despre limbă, nu neapărat ca structură lingvistică (așa cum se observă în Reddy 1979), ci ca variație lingvistică, adică modelele despre felul în care varietățile lingvistice sînt răspîndite într-o comunitate lingvistică și maniera prin care această distribuție ar trebui evaluată?

Scopul lucrării de față este de a discuta existența a două modele de bază: cel raționalist și cel romantic. Voi cartografia modalitățile prin care aceste două modele interacționează, voi descrie evoluția lor în curgerea timpului și voi explora modul în care ele pot fi întrebuințate pentru a analiza variația lingvistică actuală.
Despre adaptarea grafică a numelor proprii din prima traducere a Septuagintei în limba română (Ms. 45)
Authors: Gînsac Ana-Maria
Published: February 2016

Printre dificultățile cu care s-au confruntat întotdeauna traducătorii Bibliei se numără adaptarea numelor proprii din acest text în fiecare idiom. Unele nume proprii biblice au fost adaptate în limba română odată cu primele traduceri ale unor fragmente din Vechiul și din Noul Testament. Cele mai multe nume proprii biblice au fost însă adaptate pentru prima dată în limba română odată cu prima traducere românească a Septuagintei, efectuată de Nicolae Spătarul (Milescu) în a doua jumătate a secolului al XVII-lea și păstrată într-o copie manuscrisă revizuită (Ms. rom. 45) datînd din același secol. Sursa principală a acestei traduceri a fost o ediție a Septuagintei apărută la Frankfurt, în 1597. În spiritul literalismului care caracteriza traducerile Bibliei în epocă, tendința dominantă a traducătorului și a revizorilor a fost să conserve pe cît posibil forma numelor proprii din textul sursă, încercînd totodată să le integreze în grafia și în flexiunea limbii române. Pornind de la particularitățile formale ale numelor din textul-sursă, ne propunem să descriem unele aspecte și probleme legate de principiile grafice care au stat la baza transpunerii numelor proprii din sursa grecească în Ms. 45.
Considering CL 1699, is there enough evidence to correct the attestation of copt, –ă (1887, DLR)?
Authors: Chirilă Adina
Published: February 2016

In 1699, translating from Greek a text by Maxim the Peloponnesian, Antim Ivireanul uses a word that, at first glance, coincides with a neologism attested in Romanian no sooner than the end of the 19th century, as a French loan: copt, –ă, ‘Locuitor [...] al Egiptului, descinzând din vechile secte creștine ale Euticheenilor’ [Inhabitant (...) of Egypt, descending from the ancient Chris- tian sects of the Euticheens]. In order to answer the question in the title, the author had to conduct a semantic analysis of the corresponding word in the Greek source-text, i.e. κóπται (and also its etymology), since, for the period when Maxim the Peloponnesian writes, the Greek lexicography indicates only the existence of the ancient form κóπτης (pl. κóπται), derivative of the verb κóπ(τω) –της ‘to cut, to strike’. The study leads towards an affirmative answer, and might also cast a new light on the language dynamics of the post-byzantine era.
La salud mental y la atención primaria en México. Experiencias de un modelo de atención colaborativa
Authors: Vargas Blanca Estela ,   Servicio de Psiquiatría Comunitaria. Dirección de Servicios Clínicos. Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz., Villamil Salcedo Valerio ,   Subdirección de Investigaciones Clínicas del Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz.
Published: February 2016

Resumen

Introducción. En México, existe poca experiencia en el desarrollo de modelos en atención primaria en salud mental.

Objetivo. Estructurar y aplicar un modelo de atención colaborativa en salud mental, basado en evidencias científicas probadas en otros países.

Método. Se diseñó un modelo acorde a las características del sistema de salud de la Ciudad de México. El modelo consistió en: la capacitación del equipo de salud para detectar posibles casos, la aplicación del instrumento de tamizaje (K-10), para el diagnóstico de depresión y ansiedad, así como realizar reuniones de atención colaborativa entre los médicos generales y el especialista en psiquiatría para la supervisión de casos. Se aplicó una entrevista de opinión a los médicos generales.

Resultados. Se capacitaron 104 profesionistas. Durante tres años se detectaron 830 (50.5%) posibles casos, se valoraron el 38% de éstos en sesiones de atención colaborativa entre el médico general y el psiquiatra. El 50% de las sesiones fueron suspendidas por motivos administrativos principalmente; la asistencia de los médicos generales y de los pasantes de medicina fue regular.

Discusión y conclusión. El modelo de atención colaborativa entre el médico general y el especialista en este contexto puede funcionar. Sin embargo, se deben resolver algunas barreras administrativas, como la organización de los servicios y el número de programas que se desarrollan en el primer nivel de atención. Ante esta limitación, y dada la experiencia, se propone que los estudiantes de servicio social de medicina se involucren en este tipo de modelos, con el apoyo de los médicos generales.
Relación entre supervisión parental y conducta antisocial en menores infractores del Estado de Morelos
Authors: Carrillo Lorena ,   Dirección de Investigaciones Epidemiológicas y Psicosociales del Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz., Juárez García Francisco , González Catalina , Martínez Nora Angélica , Medina-Mora Icaza María Elena ,   Dirección General del Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz.
Published: February 2016

Resumen

Introducción. La supervisión parental comprende: cuidado de los hijos, conocimiento de su paradero y actividades y adaptación. Para que ésta se dé es necesario que exista comunicación y apoyo entre padres e hijos, de manera que el ambiente familiar sea agradable. Por otro lado, se ha encontrado que la inconsistencia o ausencia de ésta es un factor de riesgo de la conducta antisocial y, en casos más graves, de delincuencia en los hijos.

Objetivo. Conocer cuál es la relación que existe entre el ambiente familiar, la supervisión parental y la gravedad de la conducta antisocial en menores infractores.

Método. La población estuvo conformada por menores infractores de un Centro Tutelar del Estado de Morelos. El instrumento se aplicó a 86 hombres.

Resultados. La comunicación del hijo fue un predictor de: 1. el manejo de reglas y conocimiento de pares, y 2. el conocimiento de las actividades del hijo. Esto último es lo que predice de manera significativa la gravedad de la conducta antisocial.

Discusión y conclusión. De acuerdo con los hallazgos, es importante que exista un ambiente familiar basado en la comunicación y el apoyo, que fomente una comunicación más libre de los adolescentes con sus padres, de manera que la supervisión parental se consiga más fácilmente. Esto ayudará para que los jóvenes no se involucren en comportamientos que los puedan llevar a delinquir.
Evaluación psicológica de la agresividad impulsiva/predeterminada y factores asociados: Un estudio transversal en usuarios de los servicios de salud en Tabasco, México
Authors: Reyes-Tovilla Jorge E ,   División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco, Villahermosa, Tab., México., Hernández-Yánez Homero Daniel , Juárez-Rojop Isela , Tovilla-Zárate Carlos Alfonso , López-Narváez Lilia , Villar-Soto Mario , González-Castro Thelma Beatriz , Fresán Ana ,   División Multidisciplinaria de Comalcalco, Universidad Juárez Autónoma de Tabasco, Comalcalco, Tab., México.,   Hospital General de Yajalón. Secreatría de Salud, Yajalón, Chis, México.,   Servicio de Psiquiatría, Hospital de Alta Especialidad Gustavo A. Rovirosa Pérez. Villahermosa, Tab., México.,   Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz. México. DF.
Published: February 2016

Resumen

Introducción. La conducta suicida es un problema de salud pública. Se sugiere que la personalidad impulsiva o predeterminada participa en los actos de agresividad como el suicidio.

Objetivo. En este estudio se identificaron diferencias sociodemográficas, de intento de suicidio y la presencia de depresión entre individuos con característica de agresividad impulsiva o predeterminada.

Métodos. Se realizó un estudio de tipo transversal que incluyó a 200 residentes de Villahermosa, Tab, México, usuarios de los servicios de salud en ese Estado. La agresividad predeterminada o impulsiva se caracterizó usando la Escala de Agresión Impulsiva/Predeterminada (IPAS). Las características sociodemográficas, de intento de suicidio y de depresión fueron divididas de acuerdo al tipo de agresividad. Subsecuentemente fueron comparadas las características entre los dos grupos.

Resultados. Los resultados psicológicos revelaron que la agresividad impulsiva está presente en 62.71 % de la población. Estar desempleado y ser mujer fueron asociadas con la agresividad predeterminada. De igual forma, la mayor proporción de personas con depresión se observó en el grupo de personas predeterminadas (χ2 = 18.29, gl = 1, p = 0.001). La proporción de personas con por lo menos un intento de suicidio a lo largo de la vida es similar en las impulsivas y las predeterminadas (6.06% y 6.30%, respectivamente).

Discusión y conclusión. El presente estudio no muestra relación entre la personalidad y la proporción del intento de suicidio en los usuarios de los servicios de salud en Tabasco. Sin embargo, el estado de ánimo podría estar asociado con la toma de decisiones.
Neurobiología de la depresión mayor y de su tratamiento farmacológico
Authors: Cruzblanca Humberto ,   Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, Colima, Col., México., Lupercio Patricia , Collas Jorge , Castro Elena
Published: February 2016

Resumen

Introducción. La depresión mayor (DM) se debe a la interacción de factores ambientales, genéticos y epigenéticos, que atenúan la transmisión monoaminérgica en el cerebro. Sin embargo, poco se conoce sobre los mecanismos fisiopatológicos que subyacen a ella.

Objetivo. Proponer una visión integral sobre la fisiopatología de la DM y los mecanismos de acción de los fármacos antidepresivos.

Método. Se empleó la base PubMed para la búsqueda bibliográfica. La mayoría son investigaciones experimentales y estudios de genética molecular o de imágenes cerebrales en humanos.

Resultados. La DM se asocia con: i) menor volumen de la corteza cingulada anterior; ii) hiper-metabolismo del área Cg25; iii) menor expresión del receptor 5-HT1A; iv) mayor expresión de la monoamino oxidasa A. Algunos polimorfismos están asociados a la fisiopatología. El estrés crónico reduce la expresión del 5-HT1A. Los antidepresivos atenúan el hiper-metabolismo del área Cg25, estimulan la neurogénesis y activan la vía del AMPc. Encontramos que la imipramina aumenta y reduce la expresión de Gαs y Gαz, respectivamente (datos sin publicar).

Discusión y conclusión. El déficit en la transmisión monoaminérgica puede deberse a: i) el polimorfismo G1463A en el gen de la enzima hTPH2 que reduce la síntesis de serotonina; ii) el polimorfismo C(-1019)G en el gen del receptor 5-HT1A, aumentando su transcripción en el rafé e implicando menor liberación del neurotransmisor; iii) mayor degradación de las monoaminas. La menor expresión del receptor 5-HT1A se discute considerando su acción inhibitoria en la corteza prefrontal. Los cambios en la expresión de Gαs y Gαz coinciden con la estimulación de la vía del AMPc.
Aortic aneurysm in a Marfan’s syndrome patient
Authors: Priyma Nikolay Fedorovich , Popov Valeriy Vitalyevich , Komolkin Igor Aleksandrovich , Afanasyev Ardan Petrovich
Published: February 2016

Presents a case of diagnosis and successful surgical treatment of youth of 15 years with Marfan syndrome. The patient was diagnosed with aortic sinus of Valsalva and the ascending aorta, atrioventricular valve prolapse, as well as severe funnel chest. After a thorough diagnosis was made simultaneous surgery including a prosthetic aortic valve-containing conduit, suture annuloplastics atrioventricular valves, and surgical correction of the funnel chest.
Clinical difficulties of diagnostics of a syndrome of Prader–Willi
Authors: Guzeva Valentina Ivanovna , Bessonova Lyubov Borisovna , Seel Kristina Arturovna
Published: February 2016

Prader–Willi’s syndrome is a genetic anomaly which often masks under cerebral spastic infantile paralysis and myopathy diagnoses. Though at careful collecting the anamnesis, attentive survey of the patient and competent genetic inspection the diagnosis usually doesn’t raise doubts.
Manifestations of rickets in infants with transient lactose intolerance and measures for its prevention
Authors: Denisov Mikhail Yuryevich , Kochetkova Yelena Sergeyevna , Morozova Olga Nikolayevna , Alekhno Anastasiya Aleksandrovna
Published: February 2016

The frequency and characteristics of clinical symptoms of comorbid diseases — hypovitaminosis D and transient lactose intolerance in infants who were born in the Siberian region. A total of 52 infants living in Novosibirsk, including 32 childs with transient lactose intolerance (61.5 %) and 20 apparently healthy children. Studied natal risk factors. High incidence of rickets in children in both groups, and for lactose intolerance severe disease with significant bone deformities. The fundamentals of preventive measures for patients with lactose intolerance, living in areas with harsh climates.
The characteristic of energy metabolism’s infringement and possibilities of its correction in children suffering from celiac disease
Authors: Kamilova Altinoy Tursunbaevna , Dustmuhamedova Dinora Hamidovna , Khushvaktova Zaynab Abdurakhmanovna , Sirov Bladimir Nikolaevich
Published: February 2016

The results of study of energy metabolism’s infringement and possibilities of its correction in children suffering from celiac disease are presented in the article. The study was conducted from January 2009 till December, 2012 in department of gastroenterology RSSM of Center of pediatrics. 45 children with CD at the age from 3 till 14 years have been surveyed. The carried out researches have shown at patients with CD processes of energy formation are broken: synthesis АТF and АDF is lowered, their ratio is increased, values of LTT and GТТ are lowered in 4 times. Increment of a ratio laktat/piruvat is detected, that testifies to prevalence at children tissue hypoxia. Treatment of patients suffering from CD application of use phytoecdisteroid ecdisten reduces duration of kliniko-laboratory symptoms and improves values of energy metabolism.
Diagnosis of mixed-forms of persistent infections in children with gastroduodenal pathology
Authors: Ryabchuk Faina Nikolayevna , Aleksandrova Valentina Aleksandrovna
Published: February 2016

In recent years more and more frequently when mucosa of the stomach at the same time with Нelicobacter Рylori (HP) in the mucosa of the stomach and duodenum found various persistent pathogens (viruses Gripp, Herpes , HV 1 and 2 tipe, virus Epstein-Barr and Citomegalovirus). The work is devoted to a thorough diagnosis of persistent viruses in children with gastroduodenitis, which was used in the treatment of adequate antiviral therapy, contributing to the disappearance of autoantibodies from the blood, increase the effectiveness of eradication therapy and a significant improvement of the morphological structure of the stomach mucosa in children.
Dynamic of somatic-vegetative relating ontogenesis of animals and man
Authors: Pushkarev Yuriy Petrovich
Published: February 2016

In early ontogenesis the functioning reliability of physiological systems is provided by their increased functional activity in a relative rest state. The period of pronounced qualitative activity changes of physiological systems is 6-7 years of age. At 9-10 years the system organization develops, characterized by high specialization аnd integration of individual units of systems.
Opportunities electroretinography in stadying of physiological stages of maturation human retina at different ages
Authors: Konikova Olga Aleksandrovna , Brzheskiy Vladimir Vsevolodovich
Published: February 2016

The results of evaluation of the functional state of the retina in 55 healthy children of different ages (110 eyes). Distinctive features of the formation curve electroretinogram in early childhood. So in children under 6 months a-wave electroretinogram was not recorded, b-wave had a very low amplitude and increased latency. Typical configuration electroretinogramm was after 1 year of life. Noted that the maturation of cone function finishes later than the rod-function. Electroretinography objectively confirm phasing formation of functional activity of the visual system in children.
Internet Addiction: Causes, Formation Mechanisms, Diagnosis, Treatment and Prevention Approaches
Authors: Titova Vlada Viktorovna , Katkov Aleksandr Lazarevich , Chugunov Daniil Nikolaevich
Published: February 2016

The article examines the main causes and mechanisms of Internet and video game addiction providing a detailed description of the characteristics of social groups most vulnerable to addiction, as well as the clinical and psychopathological symptoms allowing for the verification of computer addiction. Special attention is paid to the methods for the rapid psychological diagnosis of computer addiction as well as to identifying predisposition through the use of large-scale testing of young people. The Internet for computer addicts is practically a perfect way to quickly fill almost any unfulfilled needs, including the need for security, respect, love, recognition, and self-actualization. This explains the fact that the social groups most vulnerable to Internet addiction are adolescents, among which the prevalence of Internet addicts in some regions is estimated to be up to 38%, studies report. We conducted a survey of humanities and non-humanities students in St. Petersburg. The total sample size was 120 people, of whom 60 persons were humanities students and 60 people, students at technical universities. On average, the subjects were aged 22 to 23. 100 % of the subjects had a computer and free internet access. The article details the results of the study and analyzed. The key element of this paper is a model for computer addiction psychotherapy based on the concept of achieving high levels of psychological health, developing an ability to avoid using drugs, as well as the model for preventing Internet addiction among risk groups.
Medical electronic resources on practical lessons on human anatomy
Authors: Nikonorova Margarita Leonidovna , Karelina Natal’ya Rafailovna
Published: February 2016

For new tasks, in modern conditions must be prepared for lifelong learning, continuous improvement, retraining and self-education, professional mobility. Actuality the ideas contained in this article is to introduce new educational technologies and active learning at the Department of Human Anatomy. Virtual learning tools allow you to add in practical exercises, including anatomical dissection, extensive computer technology and optimize the learning process, contribute to a more depth study of anatomy. Application programs are recommended for independent work of students on the study of morphological and functional sections of human anatomy; self-correction and learning. The experience of resource use Primal Pictures in medical universities. This article describes a real possibility of integrated lessons in Anatomy and Informatics. From the standpoint of Fokine RR, when teaching Informatics advisable to convert your existing methods, forms and means of teaching in open learning system. Application of multilevel hierarchies based on the theory of open systems subject to adapt it to pedagogy will help develop methods of teaching computer science on the basis of which it is possible to build different models to optimize learning and teaching process. Instruction and work in such systems will promote the rise of and development of professional competency.
Tecnologias digitais: reflexões sobre usos e excessos ilustradas pelos quadrinhos de Andre Dahmer
Authors: Cabello Janaina
Published: February 2016

RESUMO: Este artigo propõe algumas reflexões sobre possíveis atravessamentos/impactos nos processos de subjetivação pela apropriação das tecnologias digitais no século XXI e de como seus usos e (supostos) excessos têm impactado nas constituições subjetivas diante de outras maneiras de o homem mostrar/olhar/sentir/ensinar, que se constituem nas relações estabelecidas na sociedade atual. Sob uma perspectiva histórico-cultural, discute-se sobre as apropriações das tecnologias digitais e as constituições das subjetividades (individuais e num contexto social mais amplo), tendo como pano de fundo as ilustrações do quadrinista brasileiro Andre Dahmer. Essas ilustrações foram escolhidas por fazerem parte da obra do autor que, através das redes sociais, divulga um trabalho que nos provoca e nos convida a pensar sobre como nos relacionamos e, consequentemente, (nos) mostramos, (nos) olhamos, sentimos, ensinamos e aprendemos em subjetividades que são atravessadas, constituídas e reconstituídas pelas apropriações das tecnologias no cenário contemporâneo.PALAVRAS-CHAVE: novas tecnologias; tecnologias digitais; subjetividades; apropriações. ABSTRACT:This paper proposes some reflections about possible crossings/impacts on subjective processes from the appropriation of digital technologies in the twenty-first century and how their uses and (alleged) excesses have impacted on the subjective constitutions facing other ways humans can show/look/feel/teach, that constitutes the established relationships in the network society. From a historical and cultural perspective, we discuss about the appropriation of digital technologies and the constitutions of subjectivity (individual and in a wider social context), with the backdrop of the illustrations of the Brazilian cartoonist Andre Dahmer, who, through social networks, discloses his work, which provokes and invites us to think about how we relate and therefore, we show and look at ourselves, feel, teach and learn in new subjective configurations with are crossed, constituted and reconstituted by the appropriation of technologies in the contemporary scene.KEYWORDS: new technologies; digital technologies; subjectivities; appropriantions.
O mago e a academia: o discurso sobre Paulo Coelho
Authors: Do Prado Priscila Finger
Published: February 2016

RESUMO:O presente trabalho pretende analisar o discurso sobre Paulo Coelho na Academia Brasileira de Letras. Tendo em vista seu lugar discursivo de autor de best-sellers, percebemos certo desconforto da crítica e da Academia em relação ao autor que, muitas vezes, vê sua obra figurar na estante de “Auto-ajuda”. Partimos da hipótese de que esse discurso apareça de duas formas: a do silenciamento (da crítica) e a da aclamação (do público leitor). Nesse trabalho, contudo, analisaremos o discurso sobre Paulo Coelho que consta no site da Academia, tanto na sua apresentação quanto no seu discurso de posse, analisando possíveis movimentos de sentidos percebidos.PALAVRAS-CHAVE: Paulo Coelho; ABL; discurso sobre. ABSTRACT:This paper analyzes the discourse about Paulo Coelho at the Brazilian Academy of Letters. Given its discursive place of best-selling author, we noticed some discomfort from critics and the Academy towards the author who often sees their work appear on the shelf "Self-help". Our hypothesis is that the discourse on Paulo Coelho appears discursively in two ways: the silencing (critical) and acclaim (the reading public). In this work, however, we analyze the discourse about the author who appears on the Academy site, both in its presentation, and in his inaugural speech, analyzing possible movements of meanings surrounding this discourse.KEYWORDS: Paulo Coelho; ABL; discourse on.
A Foreword from the Editor
Authors: Boeynaems Jean-Marie
Published: February 2016

We are glad to publish the second issue of the Journal of Medicines Development Sciences. It illustrates three current trends in medicines development:• The rising role of small biotech companies,• The initiatives launched in many countries to boost clinical research,• The importance of an adequate education and training of physicians and scien-tists involved in medicines development.
Study of Data Mining Based Approaches For Network Intrusion Detection System
Authors: Shukla Neeraj , Yadav Nagendra
Published: February 2016

In the current era, there is ample knowledge in using Internet in social networks (such as instant messaging, video conferencing, etc.), the field of healthcare, various areas related to electronic commerce, banking and services several other fields. As computer systems based on the network plays an ever more important in modern society once they have become the target of our enemies and criminals. Therefore, we must find the best way to protect our systems. The security of a computer system is compromised during an intrusion occurs. Intrusion can be defined as “a set of actions that aim to compromise the integrity, confidentiality or availability of a resource,” for example, illegally obtain superuser privileges to attack and make out of the system (ie, Denial of Service), etc. The purpose of this document is to provide a study of some works that use data mining techniques to detect intrusions and answer some technical questions. An advance effective idea is discussed in the chapter that will detect intruders in a data storage perspective and integrate data mining and online analytical processing (OLAP) for the purpose of intrusion detection.
Removal of Heavy Metal Mn+2 by The Adsorbent Wollastonite and Effect of pH
Authors: Mansoor Aga
Published: February 2016

Water, no doubt, is the first and foremost legitimate friend of living beings on the earth. Toxic heavy metals have been a chief reason of water pollution. Several unfortunate accidents due to heavy metal contamination in aquatic environment stepped up the awareness about heavy metal toxicity and attracted attention towards their studies. Out of these Minimata tragedy in Japan due to mercury poisoning (1953-1960) and Itai disease in Japan due to cadmium toxicity (1947) are immerable. Waste containing metals may come out of a variety of separate operations such as chemical, metal processing, electroplating, metal polishing, metal cleaning, paint manufacture, battery manufacture etc. The source of wastes in metal processing is quite in good number and also highly variable, both in quality and quantity. Metals can be had in source as particle of pure metals in suspension to metal ions and complexes in solution. In the present study the adsorbent wollastonite is used to remove Mn (II) from the water of Sai river and also studied the effect of pH.
Maltrato infantil: ¿conocer su impacto económico favorece su prevención?
Authors: Loredo-Abdalá Arturo
Published: February 2016

Una patología que ha existido desde tiempo inmemorial en la humanidad es la violencia que sufren las niñas, niños y adolescentes. En 1989, en la Asamblea General de la Organización de las Naciones Unidas, se dio una atención muy especial a este problema y se enfatizó el interés superior por este grupo etario con el objetivo de evitar que se afecten sus integridades física, emocional, educativa y económica, entre otras.

 

 
Is It Possible To Induce The "Spontaneous Regression" Of Cancer? A Mechanism of Activation for the Innate Immune Response
Authors: Oleksyszyn Jozef
Published: February 2016

The article deals with a theoretical model Ã‚Â of the mechanism of the spontaneous regression of tumor, involving the activation of innate immune response. After stimulation the cells of the immune system, use glycolysis for ATP synthesis. Ã‚Â Lactic acid, the final product of glycolysis, acts as inhibitor of such activation. Therefore, highly glycolytic cancerous cells form the environment (hypoglycemia with high level of lactic acid), which is strongly inhibitory to immune cells activation. Starvation, KD (ketogenic diet) and ColeyÃ¢â‚¬â„¢s toxin induce hypoglycemia and in the long term should also lower lactic acid level. After a few days of such treatment the glucose level could increase naturally due to gluconeogenesis or by the application of significant dose of glucose. Such procedure should induce activation of immune cells response (high glucose and low lactic acid levels) and a spontaneous regression of cancer. If lactic acid concentration remained still too high and thus inhibit the activation of immune cells, the organism would require alkalization because sodium lactate is not inhibitoryÃ‚Â  to the activation of immune cells. The model explains the cases of spontaneous regression described in literature and could be easily verifiedÃ‚Â  experimentally.
Allergy and Oxidative Stress
Authors: Twardoch Magdalena , Lodwich Magdalena , Mazur Bogdan
Published: February 2016

Tlen jako pierwiastek biogenny warunkuje przebieg podstawowych procesów biochemicznych gwarantujących przeżycie komórki. Niestety, w szczególnych warunkach wysoce reaktywne formy tlenu (RFT) mogą wywierać toksyczny efekt na organizm. W niewielkich ilościach RFT są niezbędne do prawidłowego funkcjonowania komórki, jednak ich nasilone wytwarzanie, przekraczające skuteczność działania systemów antyoksydacyjnych, określane mianem stresu oksydacyjnego, sprzyja zaburzeniom struktury i funkcji komórek oraz tkanek. Współcześnie coraz częściej wskazuje się na istotny udział stresu oksydacyjnego w przebiegu i/lub etiologii przewlekłych chorób zapalnych, do których zalicza się m.in. choroby atopowe, takie jak astma oskrzelowa, atopowe zapalenie skóry czy alergiczny nieżyt nosa.
Assessment of effect of computer tomography with intravenous contrast administration on renal excretory function
Authors: Pietrzak Mikołaj , Cieślar Grzegorz
Published: February 2016

Wstęp

Pomimo opisywanego ryzyka wystąpienia nefropatii kontrastowej definiowanej jako nagłe (do 48–72 h) pogorszenie funkcji nerek po podaniu kontrastu dotychczas nie ustalono wytycznych odnośnie do granicznego poziomu markerów czynności wydalniczej nerek, dla których dopuszczalne jest wykonanie kontrastowego badania TK. Celem pracy była ocena wpływu dożylnego podania kontrastu podczas badań TK różnego typu na zmiany wartości markerów czynności wydalniczej nerek.

Materiał i metody

W prospektywnym badaniu analizowano 60 kolejnych pacjentów (25 kobiet i 35 mężczyzn), którym wykonano badanie TK z dożylnym podaniem kontrastu. W dniu badania oraz po 48 godzinach w surowicy pacjentów oznaczano stężenie markerów czynności nerek: kreatyniny, mocznika i potasu oraz obliczano współczynnik filtracji kłębuszkowej (eGFR). Pacjentów podzielono na 2 grupy zależnie od wyjściowych wartości badanych markerów: grupa 1 – wartości prawidłowe, grupa 2 – wartości przekraczające normę średnio o ok. 20%.

Wyniki

Średnie stężenie kreatyniny przed badaniem nie różniło się znamiennie od stężenia po badaniu (1,05 ± 0,23 vs. 1,03 ± 0,26 mg/dl). Średnia wartość eGFR przed badaniem nie różniła się znamiennie od wartości po badaniu (71,53 ± 18,86 vs. 74,25 ± 22,50 ml/min./1,73 m2). Nie stwierdzono również istotnych zmian stężenia mocznika i potasu po wykonaniu badania. Wartości badanych parametrów po wykonaniu badania TK nie różniły się znamiennie w stosunku do wartości wyjściowych w żadnej grupie chorych, nie były również zależne od płci i rodzaju badania TK.

Wnioski

Dożylne podanie kontrastu w trakcie badania TK nie powoduje znamiennych zmian wartości markerów czynności wydalniczej nerek u pacjentów z prawidłową czynnością nerek oraz u pacjentów z wyjściowymi wartościami markerów przekraczającymi granicę normy o ok. 20%, bez względu na płeć i rodzaj wykonanego badania.
The Effect Of The 1994 Redefinition Of The FORTUNE 500 On Its Usability As A Benchmark For Corporate Profitability
Authors: Deile Andrew J.
Published: February 2016

Virtually every Strategic Management casebook has an “advice on how to prepare cases” section.  Within this section invariably is an admonition to “crunch some numbers” (e.g., ROE, ROA).  A weakness of these advice sections is that they do not give good guidance to the student as to what to compare the “crunched numbers” to. This paper will argue that the FORTUNE 500 is an appropriate benchmark for evaluating corporate profitability.  With 48 years (1954 to 2001) of data we are able to effectively place a given firm’s profitability in perspective.  One relatively major problem exists however.  Prior to 1994, the FORTUNE 500 was really two separate 500's–the traditional “manufacturing” 500 and the “service” 500.  Beginning in 1994 FORTUNE combined these two lists.  While this might not appear to be an overwhelming problem, an examination of the profitability components of the “Dupont” equation for the FORTUNE 500 reveals some substantial dissonance. This paper suggests a relatively minor adjustment that can be made to the recent (post ‘94) numbers such that we can have a relatively congruent 48 year data set that can be used as a benchmark for all corporations except “financial institutions.”