bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of post-weaning social isolation and environment al enrichment on exploratory behavior and ankiety in Wistar rats
Authors: Tanaś Łukasz , Ostaszewski Paweł , Iwan Anna
Published: November 2023

Adverse early experience is generally regarded as a risk factor for both externalizing and internalizing behavioral disorders in humans. It can be modeled in rats by a post-weaning social isolation procedure. Effects of social isolation might possibly be ameliorated by environmental enrichment. In the current study, 24 male Wistar rats were divided post-weaning into four rearing conditions: control, environmental enrichment (EE), social isolation (SI) and a combination of the two experimental conditions; (EE+SI). Two observations of the effects of rearing conditions on the rate of social and object interactions were conducted during the juvenile and post-pubertal stages of development. The SI condition led to a marked increase of social interactions during the juvenile phase, but did not affect object interactions. The EE condition increased the level of social interactions during both the juvenile and post-pubertal measurements. The effects of early rearing conditions on adult exploratory behavior were less clear, with a significant difference between the groups obtained in one of three behavioral tests. Results suggest a general robustness in the development of adult exploratory behavior and anxiety when rats were exposed to early social isolation and provided brief opportunities for social play during the juvenile period. Further studies, aimed at distinguishing play-related protective factors serving against long-term adverse effects of juvenile social isolation, are suggested.
Comparison of dynamic behavior and maturation of neural multipotent cells derived from different spinal cord developmental stages: an in vitro study
Authors: Slovinska Lucia , Szekiova Eva , Blasko Juraj , Devaux Stéphanie , Salzet Michel , Cizkova Dasa
Published: November 2023

Neural progenitor cells (NPCs) are characterized as undifferentiated cells with the ability of self-renewal and multipotency to give rise to other cells of the nervous system. In our in vitro study we demonstrate the proliferative and differentiative potential of NPCs isolated from the spinal cord at different developmental stages (embryonal, early postnatal, adult), maintained and expanded within neurospheres (NSs). Using the NSs culture system, we examined the size, number of NSs and their fate when exposed to differentiation conditions. Based on immunocytochemical analyses for cell markers (MAP 2, GFAP, RIP) we evaluated the occurrence of various cell types: neurons, astrocytes and oligodendrocytes. The results show that NSs increased in size during cultivation time via NPC proliferation, but proliferation potential decreased Turing maturation stages. In addition, NPCs derived from spinal cord developmentally different stages gave rise to a consistent ratio of glial and neuronal progeny (3:1), and adult tissues represent a comparable source of NPCs compared to embryonal and early postnatal tissues. These data provide useful information for large-scale in vitro expansion of NPCs required for potential cell therapy after spinal cord injury.
The influence of BDNF on human umbilical cord blood stem/progenitor cells: Implications for stem cell-based therapy of neurodegenerative disorders
Authors: Paczkowska Edyta , Łuczkowska Karolina , Piecyk Katarzyna , Rogińska Dorota , Pius-Sadowska Ewa , Ustianowski Przemysław , Cecerska Elżbieta , Dołęgowska Barbara , Celewicz Zbigniew , Machaliński Bogusław
Published: November 2023

Umbilical cord blood (UCB)-derived stem/progenitor cells (SPCs) have demonstrated the potential to improve neurologic function in different experimental models. SPCs can survive after transplantation in the neural microenvironment and indu ce neuroprotection, endogenous neurogenesis by secreting a broad repertoire of trophic and immunomodulatory cytokines. In this study, the influence of brain-derived neurotrophic factor (BDNF) pre-treatment was comprehensively evaluated in a UCB-derived lineage-negative (Lin−) SPC population. UCB-derived Lin− cells were evaluated with respect to the expression of (i) neuronal markers using immunofluorescence staining and (ii) specific (TrkB) receptors for BDNF using flow cytometry. Next, after BDNF pre-treatment, Lin− cells were extensively assessed with respect to apoptosis using Western blotting and proliferation via BrdU incorporation. Furthermore, NT-3 expression levels in Lin− cells using RQ PCR and antioxidative enzyme activities were assessed. We demonstrated neuronal markers as well as TrkB expression in Lin− cells and the activation of the TrkB receptor by BDNF. BDNF pre-treatment diminished apoptosis in Lin− cells and influenced the proliferation of these cells. We observed significant changes in antioxidants as well as in the increased expression of NT-3 in Lin− cells following BDNF exposure. Complex global miRNA and mRNA profiling analyses using microarray technology and GSEA revealed the differential regulation of genes involved in the proliferation, gene expression, biosynthetic processes, translation, and protein targeting. Our results support the hypothesis that pre-treatment of stem/progenitor cells could be beneficial and may be used as an auxiliary strategy for improving the properties of SPCs.
A quantitative analysis of illusion magnitude changes induced by rotation of contextual distractor
Authors: Bulatov Aleksandr , Bulatova Natalija , Surkys Tadas , Mickienė Lina
Published: November 2023

In the present study, the predictions of the computational model of centroid extraction were verified in psychophysical examination of the length illusion induced by stimuli comprising the conventional or asymmetric Müller-Lyer wings as the contextual distractors. In experiments, the illusion magnitude changes evoked by rotation of distractors with different spatial parameters were quantitatively determined. It was demonstrated that the model calculations adequately account for the illusion magnitude variations shown by all the subjects for all modifications of stimuli. A good correspondence between the experimental and theoretical data supports the suggestion that local positional biases caused by the neural processes of automatic centroid extraction can be one of the main reasons of emergence of illusions of the Müller-Lyer type.
Chronic morphine treatment enhances sciatic nerve stimulation-induced immediate early gene expression in the rat dorsal horn
Authors: Bojovic Ognjen , Bramham Clive , Tjølsen Arne
Published: November 2023

Synaptic plasticity is a property of neurons that can be induced by conditioning electrical stimulation (CS) of afferent fibers in the spinal cord. This is a widely studied property of spinal cord and hippocampal neurons. CS has been shown to trigger enhanced expression of immediate early gene proteins (IEGPs), with peak increases observed 2 hour post stimulation. Chronic morphine treatment has been shown to promoteinduce opioid-induced hyperalgesia, and also to increase CS-induced central sensitization in the dorsal horn. As IEGP expression may contribute to development of chronic pain states, we aimed to determine whether chronic morphine treatment affects the expression of IEGPs following sciatic nerve CS. Changes in expression of the IEGPs Arc, c-Fos or Zif268 were determined in cells of the lumbar dorsal horn of the spinal cord. Chronic Morphine pretreatment over 7 days led to a significant increase in the number of IEGP positive cells observed at both 2 h and 6 h after CS. The same pattern of immunoreactivity was obtained for all IEGPs, with peak increases occurring at 2 h post CS. In contrast, morphine treatment alone in sham operated animals had no effect on IEGP expression. We conclude that chronic morphine treatment enhances stimulus-induced expression of IEGPs in the lumbar dorsal horn. These data support the notion that morphine alters gene expression responses linked to nociceptive stimulation and plasticity.
CHANNEL COMPONENT OF SEDIMENT YIELD: SPECIFIC FEATURES FOR THE LARGE RIVERS OF RUSSIA
Authors: Chalov S.R. , Zavadsky A.S. , Golovlev P.P. , Ivanov V.A.
Published: November 2023

Bank and riverbed erosion produce a significant part of the sediment flux, i.e. its channel component. The article deals with the quantitative assessment of the channel sediment input for more than 14 000 km of the lower reaches of the Ob, Yenisei, Lena, Kamchatka and the Selenga River net. The absolute volumes of sediments supplied by bank erosion are maximum for the lower and middle Lena River (up to 38,7 million tons per year per 100 km of the channel). They are significantly lower for the lower and middle Ob River (down to 19,9 million tons per year per 100 km of the channel), and an order of magnitude smaller (about 2 million tons per year) for the Yenisei River because of the limited conditions for the development of channel processes, and for the Selenga and Kamchatka rivers because of the smaller size of rivers. The volume of sediments of channel origin is two times smaller, than the sediment runoff, for the Yenisei River and exceeds the sediment runoff up to 9 times for other rivers. The maximum rates of bank erosion are common for meandering and branched channels with wide floodplains. Most of the bank erosion within the braided sections of channels is the deformation of islands.
Estrategia didáctica para el desarrollo de las habilidades motrices finas en niños de Educación Inicial
Authors: Reyes-Barcia Jessenia Maricela , Gras-Rodríguez Rolando
Published: November 2023

El desarrollo y aplicación de la estrategia didáctica implica un factor importante para brindar mejoras en las habilidades motrices finas de los niños, teniendo en cuenta que mediante las estrategias aplicadas se logran coordinar y organizar las diversas actividades que contribuyen en la adquisición de las habilidades y destrezas motrices. El objetivo del presente estudio se enmarcó en diseñar una estrategia didáctica para el desarrollo de las habilidades motrices finas en niños de 4 a 5 años de la Unidad Educativa “Olga Patricia Acebo Álvarez”. Desde una investigación de tipo descriptiva, bajo un enfoque mixto, ya que se trabajó con una muestra no probabilística a conveniencia del investigador. Se utilizó la técnica de la entrevista y la ficha de observación, las cuales fueron aplicadas a los docentes y a los niños, se indica que la propuesta fue validada mediante el criterio de especialistas. Se determinó que uno de los resultados principales es que los docentes conocen lo importante que es aplicar estrategias didácticas para fortalecer el desarrollo de las habilidades motrices finas en los niños lo cual repercute de manera directa en su desempeño, desde esta perspectiva se infiere que los niños de inicial necesitan ser motivados con actividades que les permitan desarrollar la parte motriz de una manera favorable.
Terapéutica en mesialización de molares con minimplantes: revisión bibliográfica
Authors: Quito-Vallejo Byron Enrique , Bautista-Rojas Fabián Darío
Published: November 2023

La mesialización de los molares en el maxilar inferior es prolongado, además, los molares por lo general no realizan movimientos de traslación puros. Una ventaja de la utilización de minimplantes es que permite que las fuerzas que son aplicadas en los dientes lleguen al centro de resistencia del diente. Al mismo tiempo al no producir fuerzas de reacción se obtendrá un anclaje máximo. Se debe considerar el sistema de fuerzas que se va aplicar y de qué manera podemos controlar y mejorar la biomecánica previo a aplicar cualquier tipo tracción. Es en esta parte es en donde los minimplantes desempeñan un rol importante, sobre todo en aquellas situaciones clínicas en las que deseamos obtener anclaje máximo. Esta investigación es una revisión bibliográfica sobre la terapéutica en mesialización de molares con minimplantes. Los minimplantes en ortodoncia permiten el movimiento mesial de lo molares, siendo una alternativa de tratamiento para pacientes con ausencia de órganos dentales, lo que ha facilitado o hecho más predecibles algunas maniobras, en tanto para ciertos casos, donde el tratamiento con mecánica de anclaje tradicional continúa siendo el más adecuado.
Seroprevalence study of bubaline brucellosis in Kota Division of Rajasthan using various serodiagnostic tests
Authors: SONI M , SHRINGI B N , MAHERCHANDANI S , KASHYAP S K
Published: November 2023

The study was undertaken to investigate the seroprevalence of brucellosis in buffaloes of Sangod, Mandana, Bundi, Talera, Chhabra, Jhalrapatan and Dag regions of Kota division of Rajasthan. Blood samples (436) were collected for detection of Brucella antibody using Rose Bengal plate test (RBPT), standard tube agglutination test (STAT), heat inactivation test (HIT), 2-mercaptoethanol test (2-MET), agar gel immunodiffusion test (AGID) and avidin biotin enzyme linked immunosorobent assay (AB ELISA). Overall seroprevalence was recorded as 37.84% by AB ELISA, 35.09% by RBPT, 29.59% by STAT, 26.15% in HIT, 25.23% in 2-MET and 13.99% in AGID. AB ELISA was found as the most sensitive whereas AGID was the least sensitive test. Higher number of females (38.46%) showed seropositivity as compared to males (30.30%). The results of the study indicated (a) relative suitability of ELISA as a screening test, and (b) endemacity of infection in villages of Kota division, Rajasthan.
Rumen fermentation pattern of Barbari kids at different physiological stages under semi-intensive system of production
Authors: MAMTA MAMTA , DUTTA T K , TRIPATHI M K
Published: November 2023

An experiment on 24 goat kids, 8 of each stage of growth (K1, 3–6 month; K2, 6–9 months; K3, 9–12 months) was conducted to study the rumen fermentation pattern of goat kids under semi-intensive system of feeding and management. The semi-intensive system of goat production involved 6 to 8 h daily grazing with feeding of concentrate at 1.5% of live weight, dry roughage (gram straw) ad lib. and green fodder 1,500 g/ animal/ day after grazing. The rumen fluid pH, total-N (mg/dl) and NPN (mg/dl) were similar among kid groups and mean levels were respectively 6.5, 70.81 mg/dl and 39.83 mg/dl. The TCA-ppt-N and NH3-N concentration were lower (p<0.05) in K1 (20.8 mg and 17.76 mg) kids, while K2 and K3 kids had the similar levels. The TVFA (mmol/dl) and fractional VFA were not different among kid groups and mean TVFA were 10.63 mmol/dl, while mean proportion (%) of acetate, propionate and butyrate were 66.29, 22.07 and 11.61 respectively. Therefore, it is concluded that kids at 3–6 months of age have low proteolytic activities while energy/fibrolytic activities not affected by age of kids.
Effect of sun dried whole bulb garlic powder on growth, carcass characteristics and meat quality of commercial broilers
Authors: SINGH JASWINDER , SETHI A P S , SIKKA S S , CHATLI M K , KUMAR PAVAN
Published: November 2023

A study was conducted to evaluate the effect of sun dried whole bulb garlic powder as phytogenic alternative to antibiotic growth promoters in broilers. Day-old broiler chicks (225; IBL 80) were randomly distributed to 5 treatments with 3 replicates. The dietary treatments comprises of basal diet as control, antibiotic group receiving 0.1g/kg of oxytetracycline, 1.0,1.5 and 2.0% of sun-dried whole bulb garlic powder (WBGP) added to basal diet. Daily feed intake, weekly body weight and residue left any were recorded to calculate the feed conversion and protein efficiency ratios. At the end of fifth week 2 birds / replicate were sacrificed to determine the carcass characteristics and meat sensory evaluation. Results revealed that supplementation of WBGP at 1.5% improved the body weight, which is statistically comparable with the antibiotic fed group but the feed conversion ratio was significantly lower in 1.5% WBGP supplemented group than the control and antibiotic groups. Dietary treatment does not significantly influence the carcass characteristics except the relative heart weight. Supplementation of WBGP significantly improved the meat quality parameters as compare to control group. From the results of present study, it is concluded that dietary inclusion of 1.5% sun dried WBGP can be used as phytogenic alternative to antibiotic growth promoters in broilers.
Characterization, performance and genetic diversity among goats of Odisha
Authors: VERMA N K , MISHRA PRIYANKA , AGGARWAL R A K , DIXIT S P , DANGI P S , DASH S K
Published: November 2023

Phenotypic and biometric characterization was carried out of local goat populations of Odisha. The populations included Ganjam, Kalahandi, Ghumusar, Narayanpatnam, Raigarhi and Malkangiri goats. Ganjam goats are distinctly different from other populations because of long pointed horns. The body measurements of adult (12 months) males for heart girth, height at withers, body length, and paunch girth were measured. The coat colour of goats was recorded. The average body length, body height, chest girth, paunch girth, face length, horn length, ear length and tail length in adult female and male were measured. The biometric estimates for height at withers, body length, chest girth, paunch girth, face length, horn length, ear length and tail length indicated the average measurements. Genetic Biodiversity study includes 192 individuals of goats belonging to two recognized (Ganjam and Black Bengal) breeds and 2 lesser known goat populations (Kalahandi and Ghumusar) genotyped for a battery of 25 microsatellites. The number of observed allele for each locus ranged from 2.00 to 21.00. The highest number of allele was observed for locus OarFCB304 for Ganjam goat breed and lowest number of allele was observed for locus ETH225 for Kalahandi goat population. Polymorphic Information Content (PIC) value and bottleneck analysis were studied. Ghumusar and Kalahandi have the highest genetic distance (1.996) from the others and Ganjam and Black Bengal have minimum (0.346) genetic distance. In the neighbor joining diagram. the Ghumusar and Kalahandi goat populations plots separately from the other breeds/populations.
Effect of supplementing certain vitamins and chelated trace minerals on reducing incidence of sub-clinical mastitis in crossbred cows
Authors: BHANDERI B M , GARG M R , GOSWAMI AJAY
Published: November 2023

Crossbred cows (93) having a history of sub-clinical mastitis (SCM) and clinical mastitis (CM) in previous lactation were selected from 57 farms in Sabarkantha district of Gujarat. Twenty crossbred cows from 12 farms served as control, and the remaining (n=73) were fed daily 10 g supplement per animal containing coated vitamins E and A, chelated copper (Cu), zinc (Zn), chromium (Cr), along with iodine(I), for 4 weeks prior to calving. Milk samples were collected post calving on day 10, 30, 60 and 90 for analysis of somatic cell counts (SCC), sodium (Na), potassium (K), chloride (Cl) content, pH and electrical conductivity (EC). Blood samples were also collected for neutrophil count, measurement of immunoglobulin and ferric reduction anti-oxidant power (FRAP). The milk producers were provided with Mastect strip for weekly checkup of SCM. Out of 73 supplemented cows, only 15 (21%) showed signs of SCM and CM with Mastect strip and California mastitis test, which was confirmed by SCC in milk (average 7.26×105 cells/ml milk). However, 16 animals (80%) out of 20 in control group were affected by SCM as indicated by the SCC (average 10.11×105 cells/ml milk), which was later aggravated to CM. Milk pH, EC, Na and Cl content in milk were higher in animals affected by SCM than the normal animals. In supplemental group, SCC in 58 (79%) animals was within the normal range (1.22–2.36×105 cells/ml milk) and no signs of SCM or CM were observed. Milk lactose, protein, solids-not-fat (SNF) content and FRAP were higher in unaffected as compared to mastitis affected animals. On feeding the supplement, blood neutrophil count decreased, whereas, immunoglobulin and FRAP activity increased significantly (P<0.05). The inference could be drawn that feeding a vitamins and chelated minerals based supplement 4 weeks prior to calving could significantly help in reducing the incidence of SCM in crossbred cows.
Efforts to Increase Curiosity Through Cooperative Lectures Type Student Teams Achievement Division (STAD) with Guided Discovery Approach in Economics Mathematics Course
Authors: Indah Pertiwi
Published: November 2023

The objectives of this study include: (1) To determine the implementation of cooperative lectures of the Student Teams Achievement Division (STAD) type with a guided discovery approach in the economic mathematics course of students of the D3 Accounting Study Program, Pamulang University, (2) To determine the results of the improvement curiosity in the application of cooperative lectures of the Student Teams Achievement Division (STAD) type with a guided discovery approach in the mathematical economics course of students of the D3 Accounting Study Program, Pamulang University, and (3) To find out the obstacles faced by lecturers and students as well as the efforts made in the application of cooperative lectures of the Student Teams Achievement Division (STAD) type with a guided discovery approach in economic mathematics courses for students of the D3 Accounting Study Program, Pamulang University. Research on efforts to increase curiosity through STAD type cooperative learning with a guided discovery approach in economics mathematics courses is a type of Classroom Action Research. This Classroom Action Research is intended to overcome a problem or improve a learning in the classroom. Therefore, the purpose of this research is to change the initial situation or condition to the expected condition (improvement oriented). Based on the results of research and discussion, it is concluded that learning mathematics using the STAD type cooperative model with a guided discovery approach can increase the curiosity of D3 Accounting students at Pamulang University. Learning mathematics using the STAD type cooperative model with a guided discovery approach at the D3 Accounting at Pamulang University has been carried out according to the procedure. The implementation of mathematics learning using the STAD type cooperative model with a guided discovery approach has been carried out following the steps that have been set.
Optimization of Tax Education Through Digital Content
Authors: Ardi Wijaya  , Maskuri Sutomo
Published: November 2023

Tax education is important for the public, especially for taxpayers, in order to understand their rights and obligations in paying taxes. However, tax education still does not receive adequate attention in Indonesia. Digital content as a medium for tax education offers easier access and greater flexibility for students. This research aims to review the effectiveness and challenges in optimizing tax education through digital content. The research method used in this research is a literature study analysis method to review various studies related to the effectiveness and challenges in optimizing tax education through digital content. Data is collected from academic journals, books, reports and other related articles. The results of this research reveal that digital content as a tax education medium can improve tax understanding and skills. Digital content allows digital actors to learn independently and flexibly, as well as allowing access to various learning resources, and providing more interesting and interactive interactions.
Analyzing the Public Perception of Brawl Phenomena Involving Juvenile Delinquency in Jakarta
Authors: Aulya Syifa Sagita
Published: November 2023

This paper aims to explain the use of reception theory in the case of public perception of brawl phenomena in Jakarta. The phenomenon that has been going on for years amongst Junior High School students and Senior High School students is a problem that has never ended. This issue is of significant concern due to the fact that teenagers in Indonesia, particularly within the Jakarta region, do not appear to be dissuaded by government sanctions. Consequently, a substantial number of these juvenile delinquents continue to engage in altercations between schools. Therefore, this paper focuses its attention on the reactions of individuals to reports of criminal activities involving juvenile delinquency and people’s perspectives on the Indonesian legal framework applied to this demographic. The approach employed in this paper is a qualitative methodology centered on phenomenological research, complemented by reception theory. This combined approach aids the researcher in elucidating the phenomena that occur among delinquents and in examining how the media covers these incidents.
The Role of The Use of Information Technology in Orderly Financial Administration and Tax Compliance in Digital Business
Authors: Linda Afriani  , Ipik Permana  , Dewi Muliasari  , Uswatun Khasanah
Published: November 2023

This study aims to examine the role of information technology on financial administrative order and tax compliance. We collected data through a survey on 136 digital business or startups owners/financial managers in Malang. The results show that the use of information technology has a positive effect on financial administration order; financial administration order has a positive effect on tax compliance; and the use of information technology has a positive effect on tax compliance mediated by the financial administration order. This research contributes to the knowledge by determining the relationship between the use of information technology and financial administration order as well as tax compliance to increase tax revenue in Indonesia. The digital businesses or startups use technology to maintain businesses’ financial administration order and hence, make easier calculation of taxable amounts. This research implies that the easiness of taxes payment through the online tax administration.
The Influence of Sharenting Behavior on Children's Privacy in Bandung City
Authors: Syam Maella Nur’annafi Farni , Maharani Yasmin Diningrum  , Siti Nursanti  , Sholehah
Published: November 2023

Parents feel the need to share moments of their children's lives with family and friends via social media. Especially regarding their success in raising children, they need validation from other people. So parents in the city of Bandung do not hesitate to sharenting by utilizing various platforms on social media. Parents have freedom of expression, but each child also has privacy that must be protected because the other side of sharenting can have negative impacts. This research will examine the influence of sharenting behaviors carried out by parents on children's privacy. The research method used was quantitative, with the statistical tests used being the linear regression test and the F test. The research was conducted with 100 parents in the city of Bandung. The results of the hypothesis test show that sharenting behavior (variable X) simultaneously influences children's privacy (variable Y). This is proven by the calculated F value of 44.931, which is greater than the F table of 6.010. Thus, a significant value of 0.000 is also obtained, which is lower than the probability limit of 0.05.
Compliance challenges in clinical research organizations: A USFDA inspection retrospective
Authors: Kumar T. Sudheer , Kamaraj Raju
Published: November 2023

Context: Clinical research plays a vital role in advancing medical knowledge and improving patient care. As regulatory bodies strive to ensure the integrity and safety of clinical trials, the US Food and Drug Administration (USFDA) conducts inspections to evaluate compliance with established regulations. Aims: To examine the USFDA's inspections and non-compliance actions taken against clinical research organizations (CROs) over a 13 years period. Methods: The study utilizes a comprehensive dataset compiled from publicly available records, including inspection reports, warning letters, and other regulatory documents issued by the USFDA. Through systematic data collection and analysis, this study seeks to shed light on the frequency and nature of non-compliance findings, identify common areas of concern, and evaluate the effectiveness of regulatory actions. Results: The study reveals patterns and trends in the USFDA's inspections, highlighting key compliance challenges faced by CROs. These challenges include issues related to study protocols, informed consent, data integrity, adverse event reporting, and adherence to good clinical practice (GCP) guidelines. Furthermore, this analysis explores the USFDA's warning letters to assess their impact on CROs' compliance efforts. Conclusions: The findings of this retrospective analysis can inform CROs, and other stakeholders about the areas of greatest concern in clinical research compliance. The study contributes to the ongoing efforts to enhance the quality and integrity of clinical trials, ultimately benefiting patient safety and the credibility of the research enterprise.
Catechin as Natural Product Antifouling Agent against Biofilm Forming Bacteria from Visakhapatnam Coast, Andhra Pradesh, India
Authors: Kumar G. Sravan , Shaik Ilahi , Singh Hepzibah Rani , Kumar D. Sunil , Reddy K. V. Siva , Dumpala Sridhar , Teja G.
Published: November 2023

The aim of this work was to evaluate the effectiveness of Catechin as natural product antifoulants (NPAs) by inhibiting bacterial growth. 10 different medicinal plants namely Pongamia pinnata, Mucuna pruriens, Garcinia cambogia, Acacia catechu, Curcuma longa, Curcuma xanthorrhiza, Coffea arabica, Griffonia simplicifolia, Bacopa monnieri and Piper nigrum extracts were evaluated for potential natural product antifouling agent. Of which Acacia catechu and Curcuma longa showed best results, a significant zone of inhibition of bacteria was achieved by aqueous catechin. The secondary metabolite catechin is obtained by performing TLC, further purified by HPLC. Acacia catechu has antibacterial activity even up to 50mg L-1. The proposed partial structure of Catechin a secondary metabolite (flavanoid) is obtained by the results of Nuclear Magnetic Resonance, Mass Spectra and IR Spectra.
Calidad de la atención del enfermero y satisfacción del paciente del área de emergencia en un hospital de Lima
Authors: León Dionicio Liz Yeni , Arévalo Marcos Rodolfo Amado
Published: November 2023

La satisfacción del paciente es un determinante de la calidad de los cuidos que son provistos por el personal especializado en enfermería. Los pacientes que llegan al área de urgencias requieren de una atención técnica y humanizada ya que uno de los factores que mayor incide en la recuperación del paciente es su estado emocional, el sentirse técnica y profesionalmente bien cuidado y emocionalmente atendido. El objetivo de este artículo fue determinar la relación que existe entre la calidad de atención del personal de enfermería y la satisfacción de los pacientes atendidos en el área de emergencia de un hospital de Lima. Se realizó un estudio sustentado por e método hipotético-deductivo, descriptivo, aplicado, no experimental, correlacional y transversal. La muestra fue de 93 pacientes que acudieron al área de emergencia de un hospital de Lima. Se aplicaron dos instrumentos diseñados y validados por el investigador. El cálculo de la confiabilidad mediante el estadístico Alfa de Cronbach para el cuestionario de tipo Likert de la variable calidad de cuidados arrojó 0.799 y el cuestionario con escala Likert para la variable satisfacción 0.828; ambos instrumentos fueron validos a trasvés del juicio de expertos dando por resultado que son adecuados para su aplicación. Como resultados del estudio se obtuvo el valor p= 0.606 que indicó una correlación directa calidad de atención y satisfacción del paciente. Estos resultados fueron corroborados por un nivel bueno de 69.9% en la calidad de atención de enfermería y un 65.6% de nivel de satisfecho en la satisfacción de los pacientes atendidos en el área de emergencias. Se concluye que a medida que la calidad de atención del enfermero sea buena el paciente atendido estará más satisfecho.
Biopsia de Ganglio Centinela como método de detección de metastasis axilar y beneficios de colorante Verde de Indocianina
Authors: Solis Ovalle Melissa , López Robles Luis  Eduardo
Published: November 2023

El 20% de los pacientes con cáncer de mama presentarán Metástasis axilar, lo que contribuye a los índices de morbimortalidad en cáncer de mama. El presente artículo tiene como objetivo dar a conocer el método de Biopsia Selectiva de Ganglio Centinela en pacientes con cáncer de mama y los beneficios del Trazador verde de Indocianina. Se ha realizado una investigación tipo documental, considerando como base artículos científicos desde el año 2019 al año 2023 en Idioma Inglés y Español. Es un método novedoso y accesible. La tasa de falsos negativos es del 6 al 8%.  La tasa de detección con verde de Indocianina es 97%   y como método de doble trazador 98%. La recurrencia axilar es del 1%. Se concluye que ha mejorado el abordaje terapéutico de las pacientes con cáncer de mama, promoviendo tratamientos conservadores que se enfocan en el control regional del cáncer de mama, mejorando la calidad de vida de los pacientes.
La universidad pública y sus responsabilidades en un mundo pospandémico
Authors: Aldana Mendoza Carlos
Published: November 2023

A partir de la revisión más general de la pandemia y el período pospandémico (acentuado desde la oficialización del final de la pandemia por la OMS), son planteados algunos de los efectos o rasgos socioeducativos más relevantes de esa pandemia. Estos elementos constituyen factores que tienen que ser tomados en cuenta por la universidad pública en su esfuerzo por apoyar la recuperación socioafectiva y productiva de las sociedades.
En función de esos rasgos o elementos, se exponen cuatro grandes responsabilidades atribuibles a la universidad pública en este tiempo pospandémico.
Adherencia de arroz (Oriza sativa) en fibra de coco (Cocos nucifera) evaluado en un aglomerado biodegradable
Authors: Trabanino Gómez Ronald Humberto
Published: November 2023

La relevancia radica en el aprovechamiento de cáscara de coco como sustituto de materiales no renovables como la madera; considerada como un desecho; así mismo, el arroz de segunda, los cuales causan un impacto medioambiental en ríos o vertederos clandestinos; su importancia fue analizar la adherencia de arroz (Oriza sativa) al mezclarse con fibra de estopa de coco (Cocus nucifera) en distintas proporciones, evaluado en una probeta de aglomerado biodegradable. Para comprobarlo, se analizó el índice de compactación, el módulo de ruptura y la capacidad de retención de humedad, por tres formulaciones de mezclas de estopa de coco y harina de arroz. Se concluyó que, la resistencia del aglomerado al ser compactado disminuye al aumentar la fibra, la cual va de 2.467 a 1.77 Newton; al incrementar el contenido de fibra la resistencia a la ruptura se incrementa de 0.075 a 0.125 Newton y se comporta linealmente; además retiene mayor humedad, incrementándose de 49.88 a 59.81%.
Cirugía metabólica una opción para el tratamiento de diabetes mellitus tipo 2
Authors: Fuentes Figueroa Roberto
Published: November 2023

La Diabetes Mellitus tipo 2 constituye el subtipo más diagnosticado a nivel mundial de diabetes representando un  90-95% de todos los casos, es una condición clínica debilitante, degenerativa y multifacética que supone un importante impacto sobre la salud de las personas que la padecen, constituyendo un enorme reto clínico, económico y social. Es preocupante que a pesar del gran armamento de medicamentos con los que se cuenta hoy en día para el tratamiento de estos pacientes, en un 50% no se alcanzan las metas de control definidas por la Asociación Americana de Diabetes. Se realizó una revisión documental sobre la evidencia de la cirugía metabólica como tratamiento de la diabetes mellitus con el objetivo de determinar el impacto que puede tener en estos pacientes ya que en las últimas décadas ha demostrado disminuir considerablemente los valores de glicemia en las primeras horas posoperatorias constituyendo una llamativa alternativa para el tratamiento de estos pacientes.
Evaluación de cinco mezclas de harina de papa y trigo para elaboración de pan
Authors: Miranda Castañón Angel Roberto
Published: November 2023

El objetivo fue determinar el mejor porcentaje de mezcla, calidad nutritiva y funcionalidad de cinco mezclas 0, 10, 20, 30 y 40% de harina papa y trigo para la elaboración de pan. Se realizó pruebas fisicoquímicas, nutricionales y procesos de harinización papa. El pan se trasladó a laboratorios para analizar el contenido de vitaminas, minerales, proteína, entre otros. Se analizó la funcionalidad del producto (sabor, consistencia, color, olor, textura). Los resultados del 40% de harina de papa presentó mayor porcentaje de proteína, vitamina C, potasio y rendimiento. El tratamiento con el 0% manifestó mejores resultados de hierro, vitamina A, B1 y B9. Con respecto al contenido de zinc y sodio el tratamiento 20% fue quien presenta mayor cantidad y en cuanto a fibra dietética el tratamiento al 30% manifestó mejor contenido. La calidad organoléptica con mayor aceptación fue tratamiento con 40% de harina de papa de acuerdo con el sabor
Variaciones de teodicea
Authors: Polo Blanco Jorge
Published: November 2023

En el presente trabajo intentaremos adentrarnos en un problema filosófico fundamental, a saber, el problema de la justificación del mal en la historia, y lo haremos tomando como fundamento algunos pasajes hegelianos. El objetivo es comprender cómo la teodicea, transportada desde el campo estrictamente teológico al ámbito de la historia humana, implica poner en juego un dispositivo racionalizador que conlleva, a su vez, una exaltación de la historia como sacrificio, resultando por ello incompatible el llamado «punto de vista de la historia», según este es entendido por Hegel, con la felicidad de los hombres concretos y sufrientes. Esta operación discursiva, en tanto que cumple la función de otorgar sentido a lo que de suyo no lo tiene, también debe comprenderse, por ello mismo, a la vez como poetización mistificadora y como narración justificadora de lo injustificable. De igual modo trataremos de comprender cómo este dispositivo-teodicea se ha introducido en algunos discursos histórico-políticos muy propios y definitorios de la Modernidad; e incluso tendremos ocasión de comprobar que ese mismo dispositivo funciona también en el interior de los discursos de legitimación del capitalismo propuestos desde las versiones más extremas de liberalismo económico.
TÜRK MEDENİ USUL HUKUKUNUN YÜZ YILLIK TARİHİ
Authors: BUDAK Ali Cem , ÖZKAN Yavuz
Published: November 2023

T.C. Adalet Bakanlığının “Cebri İcra Kanunu” adı altında yeni bir icra ve iflas hukuku düzenlemesinin hazırlanmasına ilişkin olup yedi yıldır süren çalışmaları, tam da Cumhuriyetimizin 100.Yılını idrak etmekte olduğumuz bir dönemde bitme aşamasına geldiğinden, icra ve iflas hukukunun 100 yıllık bu dönemdeki serüvenini özellikle değişiklikler düzeyinde ve kısaca incelemek, bu süre zarfında katedilen yolu ve icra ve iflas hukukunun maruz kaldığı ve onu içinden çıkılamaz bir “labirentler” hukuku haline getiren “travmaları” göstermek bakımından faydalı olacaktır.
OSMANLI-TÜRK ANAYASAL GELİŞMELERİNDE SOSYAL POLİTİKA
Authors: YALIN Mehmet
Published: November 2023

Toplumların iktisadi, siyasi ve sosyal seyrine bağlı olarak gelişen sosyal politika, toplumsal talep ve hareketlenmelerin etkisiyle anayasal düzenlemelere konu olmaktadır. Anayasal düzenlemelerin sosyal politikanın hukuksal bir yapıya bürünmesinde başat rol oynaması aynı zamanda Türkiye’nin sosyal politika tarihine de etki etmiştir. Sosyal politikanın, en üst düzenleyici norm olan anayasa ile sabit bir normatif gerçekliğe sahip olması, sosyal politikanın kurumsallaşması anlamında önemli bir atılımdır. Bu bağlamda, sosyal politikanın kavramsal çerçevesinin çizilmesinde referans noktası olan, anayasal düzenlemelerin nasıl ortaya konduğu hususunda olası problemlerin varlığı bu çalışmanın odak noktasını oluşturmaktadır. Bu çalışmanın amacı, Osmanlı-Türk anayasa tarihi içerisindeki anayasal gelişmeler ve düzenlemeler dikkate alınarak sosyal politikanın tarihsel sürecinin gelişimini ve boyutlarını ortaya koymaktır.
Les plantes africaines dans la parfumerie : Revue de la littérature
Authors: Caboré/Kaboré Claudine , Semdé Rasmané , Nébié Roger H. Ch. , Bationo Rémy K.
Published: November 2023

Le secteur du parfum est très dynamique. Le marché mondial de saveurs et parfums a été évalué à 26,0 milliards de dollars en 2015. Cependant, cette filière est de plus en plus envahie par les substances de synthèse dont l’usage est source de nombreuses maladies cutanées, respiratoires et parfois de cancers. Cette revue donne un aperçu des possibilités d’alternative aux substances de synthèses utilisées et de leurs impacts sur la valorisation des ressources naturelles en Afrique. Les bases de données (Scopus, PubMed) et les moteurs de recherches (Sciences Direct, Research4life, Google Scholar) ont fait l’objet d’une recherche d’articles sur les huiles essentielles d’espèces africaines utilisées en parfumerie à partir de mots clés. Un total de près 300 articles publiés sur les plantes aromatiques utilisées en parfumerie a été consulté et une cinquantaine a été retenue. L'analyse des données a permis de recenser 47 espèces de plantes africaines représentées dans 16 familles. La plupart des espèces rencontrées proviennent des pays d’Afrique du Nord et du Sud. En Afrique de l’Ouest, très peu d’espèces sont utilisées dans les formulations de parfum. Cinq formulations de parfums à base d’huiles essentielles ont également été recensées. Les parfums ont été préparés avec différents supports tel que la vaseline, l’alcool et l’eau. Les parfums ayant comme support l’eau pourrait être une alternative de forme de parfum pour les personnes sensibles à l’alcool.
Investigating Common Mutations in Exon 20 and 21 of EGFR Gene in Lung Cancer Tumor Tissue of NSCLC Type
Authors: Ekhlasi Mahsa , Charsanj Behnaz , Shahpouri Arani Zahra , Moradzadegan Atousa
Published: November 2023

Background: A mutation in the EGFR gene can be a marker for non-small cell lung cancer (NSCLC). The frequency of this mutation is very different in various countries and ethnic groups. Objectives: This study investigated the frequency of mutations in exons 20 and 21 of the EGFR gene in patients with NSCLC in Iran. Methods: Twenty paraffin blocks with an average age of 3 years were prepared from the Tehran Cancer Institute. The samples belonged to 5 women and 15 men aged 61 - 74 years and were confirmed by a pathologist in terms of positivity and type of tumor. After deparaffinization, DNA extraction was performed using a QIAGEN kit. The appropriate probes and primers were designed, and finally, the samples were examined by the real-time TaqMan method, and the data were analyzed. Results: The findings showed that 15% and 10% of patients had mutations in exon 20 and 21 of the EGFR gene, respectively. The T790M mutation of exon 20 was observed in three patients (tumors of adenocarcinoma type and large cell cancer), and L858R and L861Q mutations of exon 21 of the EGFR gene were observed. Conclusions: The frequency of mutation in exon 20 and 21 of the EGFR gene in NSCLC patients among Iranians is close to Middle Eastern and European patients, but it is very different from the frequency of this mutation among East Asian and North Asian patients.
Impact of Teaching Social Problem-Solving Skills on Quality of Life of Patients with Congestive Heart Failure
Authors: Omidi Sepideh , Kakabaraei Keivan , Amiripour Asadollah
Published: November 2023

Background: Congestive heart failure is common in the world, and most patients with this disease have low quality of life. One of the factors affecting the quality of life is mental disorders. Therefore, teaching social problem-solving skills can play an effective role in improving the quality of life (QOL). Objectives: This study aimed to investigate the effectiveness of social problem-solving skills on QOL among congestive heart failure patients. Methods: This study was conducted on 20 patients randomly assigned to control (n = 10) and experimental groups (n = 10). The groups consisted of patients with congestive heart failure (left ventricle ejection fraction (LVEF) < 45%). The experimental group received 10 one-hour sessions on social problem-solving skills. The QOL questionnaire (SF-36) was completed before, immediately, and 3 months after the intervention. Data were analyzed using SPSS (version 23) and independent and paired t-tests, as well as an analysis of covariance. Results: There was a significant difference between the QOL scores in the experimental group compared to the pre-test (P = 0.006) and follow-up (P = 0.035) (pre-test = 51.4 ± 10.5, post-test = 59.8 ± 6.6, follow-up = 55.8 ± 7.1). However, there was no significant change in the QOL scores through different stages in the control group (P > 0.05) (pre-test = 51.2 ± 10.7, post-test = 52.3 ± 10.1, follow-up = 51.3 ± 8.9). Conclusions: Teaching social problem-solving can be effective in improving the QOL in patients with congestive heart failure.
Философия науки
Authors: Касавин Илья Теодорович , Порус Владимир Натанович ,   Institute of Philosophy, Russian Academy of Sciences
Published: November 2023

The article is dedicated to the identification and analysis of existential dimensions of science, i.e., the dependence of consciousness, activity and communication of scientists on special forms of scientific culture – life-meaning universals (existentials). The article outlines the contours of the problem field of existential challenges rooted in the real life of modern science, in the crisis of the Enlightenment idea of scientific progress, in the mismatch of the norms and ideals of scientists with everyday ideas and needs. The origins of the theoretical formulation of the existential problems of science are found in the dilemma of profession and vocation (M. Weber). This is a controversy that problematizes the relationship between the scientist’s desire for objective knowledge, on the one hand, and the human dimension of scientific activity and communication, on the other. The article singles out the particular types of existing, or boundary situations in science, in which the experiences of scientists are ordered and problematized in relation to archetypal values – freedom, objectivity, creativity, rationality, truth, success, as well as in relation to such ontological categories as space and time, which reveal their value-ladeness. The subjective dimension of science, in which a personality manifests herself as overcoming internal conflicts, a free and thinking being, qualifies as the subject of an emerging research trend – the existential philosophy of science.
Отставной королевский мушкетер между наукой, салоном и будуаром
Authors: Дмитриев Игорь Сергеевич ,   Institute of Philosophy, Russian Academy of Sciences
Published: November 2023

The present paper aims to examine the biological works of Pierre-Louis Moreau de Maupertuis (1698–1759), a prominent French scientist and philosopher, on the problems of animal reproduction and heredity. His scientific career exemplifies how, in mid-eighteenth-century Europe, various scientific disciplines were intertwined with literature, art, and philosophy. In one of his major publications dealing with these issues, “Venus physique” (1745), from one role to another time and again, combining theory, observation, everyday experience, and literary narrative. His objections to preformationism unfold in a stylized literary context that itself references the more personal context of salon conversation and flirtation. Maupertuis’s epigenetic conception of reproduction (with its origins in Antiquity) drew on a wide range of arguments from a variety of sources: anatomy and monster studies, observations of racial differences and family resemblance, analysis of the breeding experience of animal breeders, microscopic observations, and chemical insights. The French scientist presented the dynamics of processes in living nature in terms of naturalized desire and aversion, which function as guiding inclinations inherent in the smallest units of organic matter. In “Venus physique”, Maupertuis, in presenting his biological views, played on the appeal in certain Parisian circles of socially acceptable epathetics associated with philosophical texts, eroticism, unorthodox religious beliefs, and illicit sexual liaisons.