bluuebunny/crossref_metadata_2025 huggingface dataset:
La dinamica edipica in adolescenza, fra sessualità puberale e aggressività inespressa
Authors: Vassallo Paolo
Published: December 2023

In questo articolo l'autore affronta la complessità dei conflitti vissuti dagli adolescen-ti nel rapporto con i loro genitori e nel rapporto con il loro corpo che cambia. L'analisi psicoanalitica di un caso di adolescente, Marco di 16 anni, permette di riflettere come la conflittualità edipica sia un concetto molto attuale e di come questo tipo di conflit-tualità, quando raggiunge certi livelli di intensità emotiva, possa tradursi in un sinto-mo invalidante per il corpo e il funzionamento mentale. L'analisi di questo caso per-mette di indagare l'importanza dei processi di identificazione che si sviluppano nel rapporto con il genitore dello stesso sesso e che favoriscono lo strutturarsi della pro-pria organizzazione del Sé. Questo caso ci dimostra come il difficile percorso verso la Soggettivazione (R. Cahn 1999) passi anche attraverso la rielaborazione di una con-flittualità con un padre incapace di uscire dal proprio narcisismo e dalle proprie af-fermazioni difensive rispetto al prendersi cura del figlio, un padre che non è stato ca-pace di superare la propria conflittualità edipica e che l'ha proiettata verso il figlio adolescente. Per Marco, lo svenire ha rappresentato una situazione di compromesso molto funzionale, un sintomo efficace che attraverso il meccanismo difensivo del "staccare la spina" ha rappresentato un'importante soluzione per l'economia psichica. Quello che viveva al momento come intollerabile Marco lo ha proiettato nel corpo, una modali-tà che gli ha permesso di affrontare la propria rabbia con maggiori risorse e disponibi-lità. Questa modalità di funzionamento mentale gli ha permesso di non perdere il controllo delle proprie pulsioni, proteggendosi dall'eventualità del crollo psichico. La psicoterapia ha aiutato Marco a rimanere in contatto con se stesso e a continuare il suo percorso evolutivo di crescita.
Il silenzio del ragno: un racconto psicoanalitico
Authors: Golasmici Stefano
Published: December 2023

Il silenzio è una misteriosa esperienza psichica: cosa c'è nel silenzio? Anche le paro-le possono avere un carattere misterioso perché conducono a molti significati, per via metaforica e simbolica. Ma il silenzio mantiene un'ulteriore aura di oscurità: mentre con le parole è possibile avviare un'attività evocativa attraverso immagini, pensieri, idee, considerazioni che nascono nell'incontro terapeutico, nel silenzio ognuno rimane intrappolato nel proprio mondo. Cosa si esprime e cosa si appaga in una persona che è allo stesso tempo silenziosa e in relazione con l'analista? Un al-tro modo per articolare questa domanda è chiedersi qual è la pulsione (libidico-aggressiva) che alimenta il silenzio e che tipo di difesa è all'opera. Vengono offerte alcune considerazioni a partire dall'esperienza del silenzio nel corso di una psico-terapia.
Mediasi Sebagai Alternatif Penyelesaian Sengketa Ekonomi Syariah
Authors: Ikhsan Muhammad Miftahul , Mukhlas Oyo Sunaryo , Sururie Ramdani Wahyu
Published: December 2023

The establishment of Law Number 3 of 2006 concerning Religious Courts has increased the authority of religious courts, namely by resolving disputes from the sharia economy. Parties to the dispute can take a path that can be resolved, namely by litigation and non-litigation. There are several ways through non-litigation, such as mediation, negotiation, arbitration, and musharawah. However, the focus of this discussion is on mediation. Supreme Court Regulation Number 1 of 2016 concerning mediation procedures in court in article 1 point 1 states that mediation is one way to resolve disputes by negotiating to obtain agreement from two parties which will be assisted by a mediator. The necessity in conducting this mediation is a provision of article 10 of PERMA SES. This provision states that judges are required to seek peace first before hearing cases. Mediators in court have a vital role in the dispute resolution process from two parties Provide facilities for dialogue, neutrality, provide agreement facilities, encourage legal compliance, confidentiality, good communication skills, make agreements, stages of the mediation process, the first to fill out the form. Both parties may choose a mediator who is submitted to the judge. The initial stage in the mediation process is to provide a resume with a maximum of five days calculated to the mediator. Furthermore, the mediator mediates with negotiation material at an unlimited mediation meeting, both posita and petitum lawsuit, The mediation process takes place within thirty days calculated from the determination to carry out mediation, can be extended again for thirty days with the agreement of two parties. If within thirty days there is no sign of successful mediation, the process can be stopped immediately. If the mediation process has been carried out by the mediator and two parties, then the mediator will draw conclusions from mediation
Fully automated insulin delivery: artificial pancreas
Authors: Barkai László
Published: December 2023

Despite the increasing use of new treatment options, the glycaemic control of most diabetes patients is not satisfactory. However, a clear advantage is documented in the subpopulation of patients applying advanced technologies. Nevertheless, there is a need to improve the replacement of islet function and to check the achievement of treatment goals in individuals with diabetes. Aiming to fulfil these requirements, new technologies need to attain. Parallel development of insulin pumps and continuous glucose monitoring devices lead to automated insulin delivery systems. The future development goal is to achieve systems not dependent on user inputs, e.g. the fully closed loop system (artificial pancreas). The biggest barriers are the non-physiological insulin delivery and glucose monitoring subcutaneous/interstitial) of the systems used currently, therefore further research will establish the long-term benefits of emerging technologies in the care of diabetes individuals.
OPPORTUNITIES AND CHALLENGES TOWARDS THE 2024 ELECTION: THE "ECHO CHAMBER" PHENOMENON AND THE INFLUENCE OF SOCIAL MEDIA ON THE LEVELS OF POLITICAL LITERACY OF BEGINNER AND MILLENNIAL VOTER
Authors: FIRMANSYAH Yasef , RAMADHONY Farid , ROHANIAH Yoyoh
Published: December 2023

This research explores the opportunities and challenges faced in preparation for the 2024 General Election, with a focus on the "echo chamber" phenomenon and the influence of social media on the political literacy level of first-time and millennial voters. This study aims to understand the impact of a polarized social media environment on young voters' political perceptions, which may influence their political participation in upcoming elections. By applying qualitative and quantitative methodologies, this research analyzes social media content, interaction patterns, and the level of political literacy of first-time and millennial voters. The research results concluded that the "echo chamber" phenomenon on social media can strengthen existing political beliefs and views, limit access to diverse information, and reduce the willingness to hear different views. The impact is felt on the level of political literacy of young voters, who tend to obtain their political information through biased and limited sources. However, this research also found that first-time voters and millennials have great potential to increase their political literacy through an educational approach that combines social media, formal education and participatory activities in society. This research provides policy recommendations that include the role of media, education and political parties in combating the negative effects of "echo chambers" and increasing the political literacy of the younger generation.
HUMAN RESOURCES MANAGEMENT STRATEGY FOR BUSINESS SUSTAINABILITY IN MSMES
Authors: NAWANGSARI Lenny Christina , SISWANTI Indra , SOELTON Mochamad
Published: December 2023

Human Resource Management (HRM) is very much needed in Micro, Small and Medium Enterprises (MSMEs) because it can improve HR competency through increasing the knowledge and skills of MSMEs. Managing human resources for MSMEs is a skill that must be possessed by MSME players. HR management in MSMEs includes recruitment, selection, placement, development, compensation (wages), retention, evaluation, promotion and termination of employment. Managing human resources for MSMEs is a skill that must be possessed by MSME players. As the global economy develops, business competition is increasingly competitive. Micro, Small and Medium Enterprises have low competitiveness, one of the causes is low product quality, lack of product innovation and limited mastery of technology. MSME products have not been able to penetrate the free market. One of the causes is the quality of goods that is not yet competitive and technological limitations, even though competitive advantage is very important for the sustainability of MSMEs. Business sustainability is a stability of business conditions, where sustainability is a business continuity system that includes growth, continuity and approaches to protect business continuity and business expansion. Business sustainability in MSMEs can be implemented by responding to rapid changes in technological innovation, focusing on long-term interests, producing environmentally friendly products and striving for the preservation of natural resources and efficient use of technology.
THE IMPORTANCE OF BRAND AWARENESS AS A MARKETING STRATEGY FOR BUSINESS SUSTAINABILITY
Authors: UTAMA Andyan Pradipta , SIHALOHO Sandro , NABILA Suci Novia
Published: December 2023

The implementation of Community Service aims to open the insight of small entrepreneurs about the importance of consumers being aware of the existence or existence of brands sold by marketers. In the midst of economic recovery conditions after the Covid-19 pandemic and supported by the ease of digital marketing, many new entrepreneurs have emerged. The number of new entrepreneurs who compete fiercely with existing entrepreneurs plus the declining purchasing power of the community makes people more selective in buying a product. There is a tendency for consumers to choose products that are well known both through product experience and based on information obtained through various sources. Consumers are more likely to be loyal by buying products from well-known brands because they feel more comfortable and perceive familiar brands as more reliable, available, easier to find, and unquestionably quality. This training is designed to make people aware as business people that consumers will not look at a company's brand if it is considered bad and has a bad reputation in the market  so that a really mature strategy is needed so that the brand can be known by many people. Consumer awareness of a brand is expected to increase satisfaction and increase consumer loyalty. Overall, participants are expected to understand the importance of brand awareness concepts and strategies, but have not been able to practice them in real and detail. Continuous participation is needed in providing training until participants are able to practice it.
DEVELOPMENT AND MANAGEMENT OF HEALTHY COMMUNITY KITCHENS AND TRAUMA HEALING FOR SARAMPAT VILLAGE REFUGEE POST CIANJUR EARTHQUAKE
Authors: BATUBARA Siti Chairiyah , FADLINA Athiya , PUTRI Meri Safarwati
Published: December 2023

Earthquakes can disturb food access in the affected area that can lead to increase food insecurity and malnutrition. Community kitchen is one of programs to maintain refugee nutritional status by community empowerment and increase food access. This community service was aim to develop and manage community kitchen for Sarampat Village Refugee Post Cianjur Earthquake. Some activities was done including preparation, construction, organizing of community kitchen, trauma healing, and at the end, handover community kitchen management to refugees. A total 190 refugees live in temporary settlements. In the second day, refugees’s breakfast, lunch, dinner was made in the community kitchen. Trauma healing for children in the temporary settlement was also conducted to recover from post-earthquake trauma. Education to manage the kitchen, Kitchen utensil, and Balance nutrition menu for 7 days was given for the refugee in the last day. Some obstacles were faced during the implementation relate to food supply. Overall, all the activities had been done well and can be implemented for similar conditions.
THE EFFECTIVENESS OF HEALTH SERVICES IN HANDLING PATIENTS AT THE PAMULANG DISTRICT HEALTH CENTER, SOUTH TANGERANG CITY
Authors: WUISAN Richrad Sutiyono , ZIVA Ratana
Published: December 2023

Quality health care is one of the satisfaction metrics that influence the patient's desire to return to effective health care The government itself. How is the Effectiveness of Patient Handling in Health Services at the Puskesmas of Pamulang District, South Tangerang City. To find out the effectiveness of Patient Handling in Health Services at the Puskesmas Pamulang District, South Tangerang City. In this writing, the author uses a qualitative method with a descriptive approach. The objectives achieved in the Pamulang Subdistrict Puskesmas unit have a variety of different opinions but the information on health services at the Pamulang Subdistrict Puskesmas runs quite transparently. the clarity of strategy owned by the Pamulang Puskesmas needs to have a clear direction and plan in accordance with the vision of health development in South Tangerang. The need to add health workers so that the goals achieved run well in accordance with the plan that has been planned. There needs to be an increase in practice hours from each poly and the health workers who serve must be swift to be more effective and there is no accumulation of patients. The ambulance fleet must be increased to overcome delays so that services become more effective and increase pre-facilities.
CLINIC IMAGE AND PATIENT VISITS: THE SERVICE-DIGITAL MARKETING CONNECTION
Authors: WIJAYA Alif Ryan , MARWAN Jubery , RASDAN Rathoyo
Published: December 2023

This study aims to investigate how the quality of service and digital marketing affect patients' interest in visiting a clinic, both directly and indirectly, with the clinic's reputation playing a middle role. The study involved 3,574 patients at the Aka Medical Center Primary Clinic in 2022, and 100 of them were surveyed for this research, which used statistical methods to analyze the data. Before the analysis, the researchers checked the accuracy and reliability of the survey. Then, they examined the collected data using statistical tests. The results show that the quality of service and digital marketing significantly influence patients' interest in visiting the clinic, both directly and through the clinic's reputation. This means that when the clinic provides excellent service and uses effective digital marketing, it boosts its reputation, which, in turn, attracts more patients.
To update and develop GRNTI Thematic Class 78 «Military Arts»
Authors:   Russian National Public Library for Science and Technology, Dmitrieva Elena Y. , Smyslova Irina S. ,   Russian National Public Library for Science and Technology, Artemenko Valery B. ,   46 Central Research Institute of the Ministry of Defense of the Russian Federation, Zuev Alexander G. ,   Defense Research Committee of the Armed Forces of the Russian Federation
Published: December 2023

The content and structure of GRNTI thematic class 78 «Military Arts» has to be updated, improved and aligned with the current status of the military discipline; and subject-specific systematization and classification of military information have to be further developed. The Russian National Public Library for Science and Technology being the head organization of the Methodological Board for STI Classification Systems, together with the Defense Research Committee of the RF Armed Forces an Research Institute 46 of the RF Defense Ministry, have prepared the proposals to develop GRNTI hierarchical branch for the military arts. Within the framework of the Government Order No. 075-01235-23-00, the RNPLS&T has accomplished the expertise and review of the proposals submitted, as well as the research to eliminate terms duplication, with the purpose to develop national scientific terminology within the subject area of military science and information, and to upgrade GRNTI links and references. Finally, 45 changes were made to the Class 78 «Military Arts», with the most changes made in the subject headings. The hierarchical branch 78 «Military Arts» in GRNTI 2022 revised and extended version comprises 10 headings of the 2nd level, 122 headings of the 3rd level and 25 links («see» – 3, «see also» – 13, «ref. from» – 6, and «equiv.» – 3).
Porting of IRBIS64 client applications to Linux
Authors:   ELNIT Association, Batrak Ivan S.
Published: December 2023

The author discusses the development of IRBIS64 client applications for Linux operating system through porting and improving original source codes using Lazarus integrated development environment.
Granulocyte transfusions in severe aplastic anemia
Authors: Rajput Roma V. , Shah Vaani , Shalhoub Ruba N. , West-Mitchell Kamille , Cha Nu Ri , Conry-Cantilena Cathy , Leitman Susan F. , Young David J. , Wells Brian , Aue Georg , Dunbar Cynthia E. , Patel Bhavisha A. , Childs Richard W. , Young Neal S. , Wu Colin O. , Groarke Emma M. , Kalsi Shelley S.
Published: December 2023

Patients with severe aplastic anemia (SAA) are at high risk for morbidity and mortality due to severe infections. We aimed to characterize the role of granulocyte transfusion (GT) in SAA. Primary outcomes were survival from first GT, including overall survival (OS) at last follow up, survival to discharge, and receipt of HSCT. Secondary outcomes included evaluation of clinical response at 7 and 30 days after GT initiation based on a clinical scoring system incorporating microbiological and radiographic response. Twenty-eight SAA patients underwent 30 GT courses with a per-dose median of 1.28 x 109 granulocyte cells/kilogram (range 0.45-4.52 x 109). OS from initial GT to median last follow up (551 days) was 50%, with 39% (11/28) alive at last follow up. Sixty-four percent (18/28) of all patients survived to hospital discharge. Patients with complete, partial, or stable response at 30 days had significantly improved OS compared to non-responders (p=0.0004). Eighty-six percent (18/21) of patients awaiting HSCT during GT underwent transplant and 62% (13/21) survived to post-HSCT discharge. Sex, type of infection, or percentage of days with absolute neutrophil count > 0.2x109/L during GT course were not predictive of survival (p=0.52, p=0.7, p=0.28). Nine of 28 (32%) patients developed new or increased human leukocyte antigen (HLA) alloimmunization during their GT course. GTs in SAA may impact survival in those with improvement or stabilization of their underlying infection. Alloimmunization can occur and OS in this population remains poor, but GTs may be a useful tool to bridge patients to curative treatment with HSCT.
PELI2 regulates early B-cell progenitor differentiation and related leukemia via the IL-7R expression
Authors: Xu Yan , Zhou Qian , Wang Xiaoming , Zhang Aijun , Qi Wentao , Li Yuan , Zheng Chengzu , Guan Jianmin , Sun Tao , Li Jingxin , Lu Chunhua , Shen Yuemao , Zhao Baobing
Published: December 2023

Little is known about the transition mechanisms that govern early lymphoid lineage progenitors from common lymphoid progenitors (CLPs). Pellino2 (PELI2) is a newly discovered E3 ubiquitin ligase, which plays important roles in inflammation and immune system. However, the physiological and molecular roles of PELI2 in the differentiation of immune cells are largely unknown. Here, by using a conditional knockout mouse model, we demonstrated that PELI2 is required for the early B-cell development and stressed hematopoiesis. PELI2 interacted with and stabilized PU.1 via K63- polyubiquitination to regulate IL-7R expression. The defects of B cell development induced by PELI2 deletion were restored by overexpression of PU.1. Similarly, PELI2 promoted TCF3 protein stability via K63- polyubiquitination to regulate IL-7R expression, which is required for the proliferation of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells. These results underscore the significance of PELI2 in both normal B lymphopoiesis and malignant B-cell acute lymphoblastic leukemia via the regulation of IL-7R expression, providing a potential therapeutic approach for BCP-ALL.
Pelatihan Jaringan Komputer Menggunakan Cisco Packet Tracer di SMK Ar Rahmah Bantul
Authors: Hardiani Tikaridha , Esi Putri Silmina  , Danur Wijayanto
Published: December 2023

SMK Ar-Rahmah berdiri pada tanggal 24 Oktober 2011. Sekolah berlokasi di komplek Pondok Pesantren Ar-Rahmah. SMK ini di bawah naungan Yayasan Bani Fakhruddin yang berlokasi di Kedungbule, Trimurti, Srandakan, Bantul, Provinsi Daerah Istimewa Yogyakarta. SMK Ar-Rahmah hanya memiliki penjurusan Teknik Komputer dan Jaringan. Untuk meningkatkan kemampuan lulusan, diperlukan pendalaman pengetahuan dan keterampilan mengenai Jaringan Komputer. Oleh sebab itu perlu diadakannya pelatihan jaringan komputer dengan memberikan penjelasan dasar-dasar Jaringan Komputer dan simulasinya menggunakan Aplikasi Cisco Packet Tracer. Pelatihan dilakukan dengan memberikan persoalan Jaringan seperti di dunia nyata yang kemudian disimulasikan dengan menggunakan Cisco Packet Tracer , sehingga dapat lebih memberikan gambaran dan meningkatkan kemampuan serta keterampilan siswa dalam bidang Jaringan Komputer. Peserta sangat antusias dengan materi yang diberikan dikarenakan sesuai dengan penjurusan dan hasil evaluasi  menunjukkan 75% peserta puas dengan pelatihan yang diberikan karena peserta mendapat wawasan lain selain pelajaran dari sekolah.
Development of Portable Massage Bed
Authors: Ramadhan Pratama Dhavid , Atesya Kesumawati Selvi , Sukmawati Noviria , Seandi Taroreh Bangkit
Published: December 2023

The development of various models of massage beds, ranging from simple to new innovations that provide more comfort and facilities that can be adjusted to your needs. The frequently used massage beds have a permanent shape, so they are difficult to carry and move when used. Portable massage beds are designed to make it easier to use from one location to another, save space, and can be adjusted according to the masseur's needs. This research aims to find out the specifications of portable massage bed products that are suitable for masseurs and patients. The sample in this study was a small scale trial of 6 masseurs at the massage clinic at Bina Darma University, Palembang, and subjects for a large scale trial were 10 people consisting of 6 masseurs and 4 patients at the massage clinic at Bina Darma University, Palembang. The stages of model development carried out are the model analysis, design and development (ADD) stages. The instrument used in this research was a questionnaire. The expert validity test results used the Content Validity Index (CVI) and Content Validity Ratio (CVR) with an average CVR value of 0.35. Based on the results of this research, it was found that the development of the portable massage bed model had good product quality as a place for patient massage. Then this model can be tested in the field on either a small or large scale (empirical validation).
Survey of Lecturers' Understanding of Sports Massage Clinic Services at Bina Darma University
Authors: Kalsum Umi , Atesya Kesumawati Selvi , Endrawan I Bagus , Martinus Martinus
Published: December 2023

Sport is a series of regular and routine physical activities carried out by individuals to achieve certain goals. Sport is a physical activity that is planned to develop various physical components. Those who perform high-intensity sports activities become tired. Fatigue can generally refer to the body losing energy until it cannot move. Work systems and human resources both depend on occupational safety and health (OSH). This study aims to determine the understanding of employee lecturers on massage services at Bina Darma University's sports massage clinic. This research is descriptive research. The research population is patients who utilize massage services at Bina Darma University's sports massage clinic. The sampling technique used is incidental sampling with a sample size of 20 people. The data collection technique used a questionnaire. Data analysis using descriptive analysis and percentage. The results of research at the Bina Darma University Sport The results of the research at Bina Darma University Sport Massage Clinic in 20 people on each question item became in the very satisfying category of 85.75%, in the satisfying category of 76.75%, in the unsatisfactory category of 2.5% and there were no patients who gave an assessment of the sports massage clinic in the very unsatisfactory category.
Digitization of education: research and experimental work: collection of materials
Authors: O.P. Pinchuk
Published: December 2023

A collection of experimental ways in digital pedagogy. We invite you on a journey through the world of scientific research and pedagogical experiments of the Institute of Digitalization of Education of the National Academy of Pedagogical Sciences of Ukraine. Discover innovative approaches to education and digital learning, represented both by the collective research of the structural divisions of the institution, and by the individual achievements of graduate students and scholars. This collection leads into the world of pedagogical innovations, where each experiment is a step in the direction of improving learning and developing digital technologies in education. The collection contains materials of innovative projects and pedagogical experiments carried out under the guidance and direct participation of scientists of the institute.
Usulan Desain Sasis Sepeda Motor Listrik Menggunakan Pendekatan Data Antropometri
Authors: Ardana Hudha Dwi , Juhara Sutresna , Rahayu Monita
Published: December 2023

Kendaraan berbahan bakar listrik terus berkembang, khususnya sepeda motor listrik yang banyak mendapatkan perhatian dari pemerintah, seperti data yang diperkirakan MENHUB akan kebutuhan kendaraan listrik hingga tahun 2030 mencapai 132.000 unit. Sasis menjadi salah satu bagian terpenting pada sepeda motor, adanya pembuatan sepeda motor yang terus meningkat akan tetapi banyak yang kurang memperhatikan kenyamanan pada pembuatannya.  PEI (Perhimpunan Ergonomi Indonesia) menjadi tempat pengambilan data yang kemudian di olah dengan percentile untuk mendapatkan ukuran yang sesuai kebutuhan masyarakat,  hasil perhitungan yang diusulkan dari hasil yang diinginkan pengguna dan memiliki kriteria ergonomi dimana 50 cm untuk ukuran tinggi dari tempat duduk ke alas kaki, 67 cm ukuran tempat duduk ke lantai, 41 cm untuk jarak tempat duduk ke kemudi, 29 cm untuk panjang alas kaki, 25 cm lebar tempat duduk, 70 cm panjang total kemudi, dan 14 cm untuk lebar genggam kemudi. Hasil dari perhitungan dan desain yang dibuat diminta tanggapan dari pengguna yang mana 26,7% menyatakan cukup bagus 26,7%, inovatif 26,7%, menarik 33,3%, dan nyaman 13,3%.
Rancang Bangun Aplikasi Kasir Dan Stok Barang Di Apotek Munawwarah Farma Berbasis Website
Authors: Iqbal Muhammad , Djamaludin Djamaludin , Anam Muhammad Khoirul
Published: December 2023

Background: Information and communication technology enables the collection of information quickly and efficiently, enabling better data management from company locations. Additionally, this technology can help businesses in formulating the best strategies and policy owners by acting as a catalyst for accurate decision making. After talking to and observing store owners, it became clear that they faced a number of difficulties in running their businesses on a daily basis, especially when it came to tracking sales transactions and managing inventory. This analysis shows that there has never been an application for managing sales transactions and inventory. To manage transactions more quickly, the Munawwarah Farma Pharmacy store must have a computerized system that supports the sales process, so that it can help the transaction process run quickly and precisely. Method: In this research, researchers implemented the Agile Software Development method in a web-based sales and stock recording application. Purpose: This application also has a feature for managing access rights so that shop owners can regulate which pages can be accessed by employees or cashiers, so that they can maintain the security of stock data to avoid unwanted things. Research Results: Based on the design results of the implementation of the Agile Software Development method in the web-based application for sales and stock of goods at the Munawwarah Farma Pharmacy shop which has a sales transaction feature using a barcode scanner and also in this application there are details of sales and purchases which can help shop owners to can manage stock of goods easily.
Analisa Pengaruh Putar Balik (U-Turn) Terhadap Kinerja Lalu Lintas (Studi Kasus :Jalan Gatot Subroto, Kota Tangerang)
Authors: Aji Ibrahim , Rahayu Monita , Basid Abdul
Published: December 2023

Tangerang City area is one of the areas in Banten Province which is right on the west side of DKI Jakarta, the capital city of Indonesia. Tangerang City is one of the largest cities in the JABODETABEK. With the increase in population mobility, the higher the traffic flow, the more traffic that causes congestion, because the number of vehicles is always increasing and not matched by the expansion of the area. To improve safety and comfort and also minimize traffic problems on the road, a median can be made. One of the influences when making a U-Turn is when the vehicle speed will slow down or stop for a moment. Seeing this problem, it is necessary to analyze the influence of the distance between U-turns that occurs on Gatot Subroto street, Tangerang City. In tihs study the authors used a quantitative method where the authors obtained numerical data from direct observation. Based on results of the study, it is shown that the distances between the U-Turns that are very close together causes vehicles that cross the road to be hampered by their journey, then the highest average daily traffic volume peak is 2951,1 smp/jam which occurs on Monday at 18.00-19.00. traffic flow performance on the eastbound Gatot Subroto road section has the highest degree of saturation of 0,94 with the class E road service level category, while for the west direction has the highest degree of saturation of 1,05 with the class F road service level category.
Pengembangan Produk Jam Water Weker Dengan Metode Quality Function Deployment
Authors: Saefullah Kalam Mahardika , Rahayu Monita , Juhara Sutresna
Published: December 2023

Alarm clocks becoming more modern as time, and fewer people use them because there are many tools to serve as time reminders, for example, cellphones, etc. However, this development has negative impact on the body, to the radiation produces. Therefore, author will develop this alarm clock to make it look more attractive to people who no longer use alarm clocks and don't only serve as a time reminder. Methodology process making this water alarm product includes many very important considerations because has go through several trial sessions with the alarm clock which will replaced replacing or increasing some of the materials for its manufacture, in particular a fish aquarium with a size of Â±200 mm will be made by adding more tools to help circulate water when the alarm sounds to find out the amount of consumer demand using the Quality Function Deployment (QFD) method. From the results the validity test output of questionnaire distributed to respondents, there are 13 valid attributes and 2 invalid attributes. Therefore, from the results of data adequacy test, it sufficient to carry out product designs according the wishes or needs of the customer, which can be seen in the HOQ (House of Quality) image.
A Psychoanalytic Study of Envy
Authors:   The Korean Society of Culture and Convergence, Hwang Jiyoung , Kim Taewan
Published: December 2023

As one of the most basic and primal emotions experienced by humans, this study aims to explore the destructive and evil negative aspects of envy, as well as its adaptation and reparation. The results of the study showed that, if envy is transformed into creativity through the internalization of a good inner object-relationship experience, the integration of the divided self with the drive for reparation by the instinct of life, and the emotion of gratitude for the object, it is possible to live subjectively with others. Therefore, we expect to create opportunities for self-awareness through envy in our own lives, so that we can live a subjectively mature life.
Preferred Nail Shapes by Demographic Characteristics and Nail Art Extension Length
Authors:   The Korean Society of Culture and Convergence, Kim Chaehee , Ryu Heewook , Jung Somyoung
Published: December 2023

The purpose of this paper is to identify preferred nail shapes by extension length and preference trends according to demographic characteristics when performing nail extension procedures in nail art. For this purpose, the subjects of the study were people in their 20s to 50s who had experience receiving nail care, and their preferences for hands that had undergone nail extension treatment in four nail shapes (round, square, oval, and arrowhead) were analyzed. In preference for nail shape, round was dominant regardless of extension length, oval and square were similar, and arrowhead shapes were low. However, preferences according to extension length were different depending on gender, age, occupation, and marital status. Women, younger age, unmarried, and regular nail care groups showed less preference for round nails and more diverse preferred nail shapes. These results suggest that preferred nail shapes vary depending on extension length and demographic characteristics, and can be used as very useful information by nail art designers when counseling customers.
Comparative Aanalysis of Beginner Texbook Piano Techniques
Authors:   The Korean Society of Culture and Convergence, Nam Kyungeun
Published: December 2023

The purpose of this paper is to understand technique teaching methods and textbook literature by comparing and analyzing the beginner piano techniques of Piano Adventure, Piano Academia, Magic Finger Piano, which are domestic and foreign piano textbooks using a parallel reading approach. For the study, based on three references piano teaching strategies for 21st century teachers, successful piano teaching methods, and general theory of piano pedagogy, the study categorizes 10 techniques within the beginner learning goals. Next, the beginner techniques for each textbook are analyzed into the 10 types above. As a result, it was found that 7-8 techniques were evenly distributed through the three characteristic techniques icons, and that other techniques were classified as additional techniques and intermediate techniques. Accordingly, though detailed comparison and analysis, similar techniques are grouped and supplementary and characteristic techniques are selected. It will expand the range of technique education and textbook selection for domestic piano teachers and students who rely on Bayer.
Enhancing computational scalability in Blockchain by leveraging improvement in consensus algorithm
Authors: Jabbar Sohail , Abideen Zain Ul , Khalid Shehzad , Ahmad Awais , Raza Umar , Akram Sheeraz
Published: December 2023

Accommodating an increasing number of users in the Blockchain network has moved to the forefront of discussion. It is also evident that without jeopardizing the data security in Blockchain, it is of indispensable need to devise an appropriate method for improving the scalability trait of Blockchain. In this article, we have proposed a consensus method that is having the potential to improve the scalability of the Private Blockchain. The system, at first, mitigates latency arising from kernel schedulers, ensuring that the application consistently has access to an available core for transaction processing. Secondly, the committee system alleviates the network's workload, preventing spurious transactions from monopolizing network resources and impeding its efficiency. Extensive experimentation is made by considering various scenarios of transaction with CPU isolation and application sticking to core 2 with varied priority. Based on the number of transactions performed per second, the proposed system is compared with different existing consensus mechanisms working in various types of Blockchains. Also, a detailed discussion is presented on the critical analysis of the adopted research mechanism. Overall, the proposed systems outperforms to other systems in various parameters of blockchain network scalability.
Association of the polymorphisms of the cholesteryl ester transfer protein gene with coronary artery disease: a meta-analysis
Authors: Zhang Ruizhe , Xie Qingya , Xiao Pingxi
Published: December 2023

Aims

This meta-analysis aimed to assess the association of the polymorphisms of cholesterol ester transfer protein (CETP) rs708272 (G>A), rs5882 (G>A), rs1800775 (C>A), rs4783961 (G>A), rs247616 (C>T), rs5883 (C>T), rs1800776 (C>A), and rs1532624 (C>A) with coronary artery disease (CAD) and the related underlying mechanisms.

Methods

A comprehensive search was performed using five databases such as PubMed, EMBASE, Web of Science, Cochrane Library and Scopus to obtain the appropriate articles. The quality of the included studies was assessed by the Newcastle-Ottawa Scale. The statistical analysis of the data was performed using STATA 17.0 software. The association between CETP gene polymorphisms and risk of CAD was estimated using the pooled odds ratio (OR) and 95% confidence interval (95% CI). The association of CETP gene polymorphisms with lipids and with CETP levels was assessed using the pooled standardized mean difference and corresponding 95% CI. P < 0.05 was considered statistically significant.

Results

A total of 70 case-control studies with 30,619 cases and 31,836 controls from 46 articles were included. The results showed the CETP rs708272 polymorphism was significantly associated with a reduced risk of CAD under the allele model (OR = 0.846, P < 0.001), the dominant model (OR = 0.838, P < 0.001) and the recessive model (OR = 0.758, P < 0.001). AA genotype and GA genotype corresponded to higher high-density lipoprotein cholesterol (HDL-C) concentrations in the blood compared with GG genotype across the studied groups (all P < 0.05). The CETP rs5882 and rs1800775 polymorphisms were not significantly associated with CAD under the allele model (P = 0.802, P = 0.392), the dominant model (P = 0.556, P = 0.183) and the recessive model (P = 0.429, P = 0.551). Similarly, the other mentioned gene polymorphisms were not significantly associated with CAD under the three genetic models.

Conclusions

The CETP rs708272 polymorphism shows a significant association with CAD, and the carriers of the allele A are associated with a lower risk of CAD and higher HDL-C concentrations in the blood compared to the non-carriers. The CETP rs5882, rs1800775, rs4783961, rs247616, rs5883, rs1800776, and rs1532624 are not significantly associated with CAD.

Systematic Review Registration

https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023432865, identifier: CRD42023432865.
Exploring postoperative atrial fibrillation after non-cardiac surgery: mechanisms, risk factors, and prevention strategies
Authors: Jiang Shengjie , Liao Xiaozu , Chen Yong , Li Binfei
Published: December 2023

Atrial fibrillation (AF) stands as the most prevalent persistent arrhythmia and a common complication after surgical procedures. Although the majority of non-cardiac surgery patients experience postoperative AF (POAF) and the condition is typically self-limited and asymptomatic, its detrimental impact on patient outcomes, prolonged hospitalization, and heightened risk of stroke and overall mortality has become increasingly evident. Of significant concern, POAF emerges as a noteworthy risk factor for stroke, myocardial infarction, and mortality in comparison to patients with non-surgical atrial fibrillation. Multiple studies have corroborated the association between POAF and an elevated risk of stroke and mortality. The development of postoperative atrial fibrillation is multifactorial, with the inflammatory response being a primary contributor; additionally, factors such as hypovolemia, intraoperative hypotension, anemia, trauma, and pain can trigger POAF. Risk factors for POAF in non-cardiac surgery primarily relate to age, hypertension, obesity, prior cardiac disease, obstructive sleep apnea, and male sex. Prophylactic treatment with β-blockers, amiodarone, or magnesium has demonstrated efficacy, but further trials are warranted, especially in high-risk populations. This review provides an account of the incidence rate, pathophysiology, and prognosis of atrial fibrillation after non-cardiac surgery, elucidates the underlying mechanisms of its occurrence, and explores various preventive strategies investigated in this domain.
Incidence density of hyperuricemia and association between metabolism-related predisposing risk factors and serum urate in Chinese adults: a cohort study
Authors: Liang Hailun , Zhang Jijuan , Yu Hancheng , Ding Lijie , Liu Feng , Wang Jun
Published: December 2023

Background

Evidence regarding the association between metabolism-related indicators and serum urate (SU) is limited. We aimed to obtain the incidence density of hyperuricemia and to explore the association between metabolism-related predisposing risk factors and SU.

Methods

A total of 48,979 Chinese adults from the Beijing Physical Examination Center were included in the study. The partial least squares path model was used to explore the relationship between SU and metabolism-related risk factors. The generalized additive model was used for smooth curve fitting, showing the sex-specific associations of SU at follow-up with baseline fasting blood glucose (FBG) concentrations and age.

Results

The incidence density of hyperuricemia was 78/1000 person-years. Baseline SU, age, sex, obesity, FBG, and lipid metabolism were significantly associated with SU at follow-up (all P values <0.05). Non-linear relationships were found between the baseline FBG concentrations and SU at follow-up, while U-shaped associations were observed between baseline age and SU at follow-up.

Conclusions

The SU concentration is associated with several metabolism-related risk factors such as obesity and FBG. Recognition of these associations will aid in a deeper understanding of the multifaceted nature of SU regulation.
Genetic influence on urinary vitamin D binding protein excretion and serum levels: a focus on rs4588 C>A polymorphism in the GC gene
Authors: Doğan Durmus , Özcan Eda Gül , Çakır Dilek Ülker , Sılan Fatma
Published: December 2023

Introduction

Vitamin D binding protein (VDBP) plays a crucial role in vitamin D transport and metabolism. The rs4588-A polymorphism of the GC gene, encoding VDBP, has been associated with altered serum VDBP and 25-hydroxyvitamin D (25OHD) levels. However, the mechanisms underlying these effects remain unclear. We aimed to investigate the relationship between urinary VDBP excretion and serum VDBP and 25OHD levels in individuals with and without the rs4588-A allele.

Methods

A cross-sectional study was conducted on 109 children (mean age: 11.96 years) to explore the impact of rs4588-A on vitamin D metabolism and urinary VDBP excretion. Biochemical analyses determined serum 25OHD and VDBP levels, and urinary VDBP-to-creatinine ratio (u-VDBP/Cr). Genotyping for rs4588 SNP was performed using LightSNiP assay. Statistical analyses included correlation, linear regression, and comparison between allele groups.

Results

Participants carrying the rs4588-A allele exhibited lower serum 25OHD levels compared to non-carriers (median (IQR): 11.85 (3.5) vs. 12.86 (4.9), p = 0.023). However, no statistically significant differences were observed in serum VDBP levels (126.34 ± 59.3 in rs4588-A vs. 136.49 ± 51.3 in non-rs4588-A, p = 0.141) or in u-VDBP/Cr (median (IQR): 0.4 (0.35) in rs4588-A vs. 0.386 (0.43) in non-rs4588-A, p = 0.189) between the two allele groups. A significant inverse correlation between u-VDBP/Cr and serum VDBP levels was found only in rs4588-A carriers (r = -0.367, p = 0.024). No such correlation was observed in non-carriers or the entire cohort. A linear regression analysis confirmed the impact of u-VDBP/Cr on serum VDBP levels in rs4588-A carriers (B = -0.269, t = -2.185, p = 0.035).

Conclusion

Individuals with the rs4588-A allele in the GC gene had lower serum 25OHD levels. An inverse correlation between urinary VDBP excretion and serum VDBP levels was observed, suggesting a partial role of the renal pathway in altered serum VDBP and 25OHD levels linked to the rs4588-A allele.
Methylation and transcriptomic expression profiles of HUVEC in the oxygen and glucose deprivation model and its clinical implications in AMI patients
Authors: Tang Yuning , Wang Yongxiang , Wang Shengxiang , Wang Runqing , Xu Jin , Peng Yu , Ding Liqiong , Zhao Jing , Zhou Gang , Sun Shougang , Zhang Zheng
Published: December 2023

The obstructed coronary artery undergoes a series of pathological changes due to ischemic-hypoxic shocks during acute myocardial infarction (AMI). However, the altered DNA methylation levels in endothelial cells under these conditions and their implication for the etiopathology of AMI have not been investigated in detail. This study aimed to explore the relationship between DNA methylation and pathologically altered gene expression profile in human umbilical vein endothelial cells (HUVECs) subjected to oxygen-glucose deprivation (OGD), and its clinical implications in AMI patients. The Illumina Infinium MethylationEPIC BeadChip assay was used to explore the genome-wide DNA methylation profile using the Novaseq6000 platform for mRNA sequencing in 3 pairs of HUVEC-OGD and control samples. GO and KEGG pathway enrichment analyses, as well as correlation, causal inference test (CIT), and protein-protein interaction (PPI) analyses identified 22 hub genes that were validated by MethylTarget sequencing as well as qRT-PCR. ELISA was used to detect four target molecules associated with the progression of AMI. A total of 2,524 differentially expressed genes (DEGs) and 22,148 differentially methylated positions (DMPs) corresponding to 6,642 differentially methylated genes (DMGs) were screened (|Δβ|>0.1 and detection p < 0.05). After GO, KEGG, correlation, CIT, and PPI analyses, 441 genes were filtered. qRT-PCR confirmed the overexpression of VEGFA, CCL2, TSP-1, SQSTM1, BCL2L11, and TIMP3 genes, and downregulation of MYC, CD44, BDNF, GNAQ, RUNX1, ETS1, NGFR, MME, SEMA6A, GNAI1, IFIT1, and MEIS1. DNA fragments BDNF_1_ (r = 0.931, p < 0.0001) and SQSTM1_2_NEW (r = 0.758, p = 0.0043) were positively correlated with the expressions of corresponding genes, and MYC_1_ (r = −0.8245, p = 0.001) was negatively correlated. Furthermore, ELISA confirmed TNFSF10 and BDNF were elevated in the peripheral blood of AMI patients (p = 0.0284 and p = 0.0142, respectively). Combined sequencing from in vitro cellular assays with clinical samples, aiming to establish the potential causal chain of the causal factor (DNA methylation) - mediator (mRNA)—cell outcome (endothelial cell ischemic-hypoxic injury)-clinical outcome (AMI), our study identified promising OGD-specific genes, which provided a solid basis for screening fundamental diagnostic and prognostic biomarkers of coronary endothelial cell injury of AMI. Moreover, it furnished the first evidence that during ischemia and hypoxia, the expression of BNDF was regulated by DNA methylation in endothelial cells and elevated in peripheral blood.