bluuebunny/crossref_metadata_2025 huggingface dataset:
A patient with novel homozygous SPATA5L1(AFG2B) variant related to severe neuromotor delay, spasticity by whole exome re-analysis
Authors: YUCEL Peren PERK , CENNETOGLU Pakize , OZDEMIR Gizem , CAKMAK Merve , GEZDIRICI Alper , KAFADAR Ihsan
Published: July 2023

Neurodevelopmental Disorder with Hearing Loss and Spasticity; NEDHLS is recently defined autosomal recessive inherited genetic disease characterized by intellectual disability, spastic-dystonic cerebral palsy features, deafness and epilepsy. Until now, totally 48 individuals with SPATA5L1(AFG2B) variant from have been identified, including our individual we presented and approximately half of them have had microcephaly, epileptic seizures, cerebral palsy features. This gene improves normal brain and inner ear morphology and functions. As a consequence of damages on SPATA5L1(AFG2B) gene, cortical atrophy, loss of brain volume, periventricular leukomalacia and corpus callosum abnormalities are determined in brain MRG, and then sensorineural hearing loss clinically. Symptoms and signs resulted from NEDHLS associated with SPATA5L1(AFG2B) variant may mimic cerebral palsy. Here, we present a 4-year-old female patient with a novel homozygous SPATA5L1(AFG2B) variant by WES re-analysis performed in 2022, who was followed up with a diagnosis of cerebral palsy that could not be diagnosed with WES in 2020.
Conformable fractional Traub's method for solving nonlinear systems
Authors: Wang Xiaofeng , Xu Jiayi
Published: July 2023

In this paper, a new conformable fractional Traub's method is proposed for solving nonlinear systems. It can be proved that the order of convergence is 3. Experimental results show that the new proposed method requires fewer iterations in the calculation process than conformable fractional Newton's method. And the convergence planes shows good stability.
Construction and validation of a prognostic nomogram model for SCLC patients in Shandong Province, China
Authors: Song Ziqian , Ma Hengmin , Sun Hao , Li Qiuxia , Liu Yan , Xie Jing , Feng Yukun , Shang Yuwang , Ma Kena , Zhang Nan , Wang Jialin
Published: July 2023

Background: The prognosis of patients with small cell lung cancer (SCLC) is poor. We aim to figure out the survival rate of SCLC and construct a nomogram survival prediction for SCLC patients in Shandong.
Methods: We collected the clinical data of 2219 SCLC patients in various tumor hospitals and general hospitals in fifteen cities in Shandong province from 2010-2014, and the data were randomly divided into a training set and a validation set according to 7:3. We used univariate and multivariate to determine the independent prognostic factors of SCLC, and developed a prognostic nomogram model based on these factors. The predictive discriminatory and accuracy performance of this model was evaluated by the area under the receiver operator characteristic (ROC) curve (AUC), and calibration curves.
Results: The overall 5-year survival rate of Shandong SCLC patients was 14.27% with the median survival time being 15.77 months. Multivariate analysis showed that region, sex, age, year of diagnosis, TNM stage (assigned according to the AJCC 8th edition), and treatment type (surgery, chemotherapy, and radiotherapy) were independent prognostic factors and were included in the prognostic nomogram model. The AUC of the training set was 0.724, 0.710, and 0.704 for 1-year, 3-year, and 5-year; the AUC of the validation set was 0.678, 0.670, and 0.683 for 1-year, 3-year, and 5-year. The calibration curves of the prediction are consistent with the ideal curve.
Conclusion: We construct a nomogram prognostic model to predict SCLC prognosis with certain discrimination which can provide both clinicians and patients with an effective tool for predicting outcomes and guiding treatment decisions.
Ultrasonic-assisted synthesis, characterization, and release kinetics of Sweetgum (Liquidambar orientalis Miller) essential oil microcapsules as efficient antibacterial materials
Authors: Caglar Seyma , Sahbaz Deniz Akin
Published: July 2023

The development of new antibacterial materials is an essential global requirement. Sweetgum essential oil (SGEO) has potential biological activities including antifungal, antitermite, antioxidant, and antibacterial properties. Microencapsulation is one of the most promising ways to improve physical and chemical stability of essential oils, to prevent thermal degradation, volatilization, and undesirable reactions, and to control release of active components. In this study, it was aimed to synthesize the SGEO microcapsules as new antibacterial materials by ultrasonic-assisted complex coacervation of gelatin and gum Arabic. The coacervation between gelatin and gum Arabic as functions of gelatin:gum Arabic ratio, core material load, and ultrasonication time was investigated. The SGEO microcapsules were characterized by FESEM, FTIR, TGA, and XRD. The SGEO release of the microcapsules was investigated, and best fit was observed with the Korsmeyer-Peppas model. The antibacterial activity of the microcapsules against Gram–positive and Gram–negative microorganisms (Staphylococcus aureus and Escherichia coli) were also evaluated, and it was observed that the microcapsules had strong antibacterial activity against the two common pathogenic bacteria. All the results show that the SGEO microcapsules can be candidates as novel antibacterial materials and may be used to make contributions to antibacterial properties of different industrial products.
Long-term exposure to polystyrene microplastics promotes HFD-induced obesity in mice through exacerbating microbiota dysbiosis
Authors: Zhai Zhian , Yang Ying , Wu Zhenlong
Published: July 2023

Background:Microplastics (MPs) have become a global environmental problem, emerging as contaminants with potentially alarming consequences. However, long-term exposure to MPs and its effects on the development of obesity are not yet fully understood. This study aimed to investigate the effect of polystyrene (PS)-MPs exposure on high fat diets (HFD)-induced obesity and underlying mechanisms.
Methods:In the present study, C57BL/6J mice were fed a normal diet (ND) or a HFD in the absence or presence PS-MPs via oral administration for 8 weeks. Antibiotic depletion of the microbiota and fecal microbiota transplantation (FMT) were performed to assess the influence of PS-MPs on intestinal microbial ecology. We performed 16S rRNA sequencing to dissect microbial discrepancies, and investigated the dysbiosis-associated mucous layer damage and systemic inflammation.
Results:We found that PS-MPs supplementation led to an increased body weight, increases of liver weight, development of hepatic steatosis, elevated tissues mass of white adipose, and induced glucose intolerance and hyperlipemia. At the molecular level, PS-MPs administration was associated with enhanced protein levels of C/EBPα and PPARγ two critical transcription factors that regulate lipid metabolism in the liver, while reducing the protein level of PGC-1α in HFD-fed mice. Furthermore, 16S rRNA sequencing of the fecal microbiota indicated that PS increased the diversity and changed composition of the gut microbiota in HFD-fed mice. Potential relations analysis revealed that PS induced microbiota dysbiosis was associated with obesity.Interestingly, microbiota-depleted mice were resistance to PS-induced obesity, suggesting that intestinal microbiota played a critical role in PS-induced obesity pathogenesis. Importantly, transplantation of PS-altered microbiota to microbiota-depleted HFD-fed mice promoted colon mucus layer damage, systematic inflammation and obesity.
Conclusions: Our findings provide a new gut microbiota-driven mechanism for PS-induced obesity in HFD-fed mice, suggesting the need to reevaluate the adverse health effects of MPs commonly existed in daily life, particularly in susceptible population.
The estimation of seismic hazards in Eastern Turkey and its surrounding area by statistical approaches
Authors: Altınoğlu Fatma Figen , Polat Gulten
Published: July 2023

In this study, a complete set of 19933 earthquake data in the depth range from 1 to 30 km from 12 December 1905 to 30 September 2022 was collected and analysed by using the Gutenberg–Richter (GR) earthquake frequency magnitude relationship approach to determine b-value and completeness magnitude (Mc). The size scaling b- and a-values for the overall catalogue were estimated as 0.82 ± 0.01 and 5.452, respectively. The Mc for the entire investigated region was estimated to be equal to 1.9. The observed low b-values were most likely related to differential crustal stress and strain produced by large faults located in the study region. It means that the region is prone to destructive and massive earth-quakes with high magnitudes. Statistical seismic hazard analysis methods including Gutenberg-Richter Law (GR) and Generalized Poisson Regression (GPR) were also used to detect earthquake occurrence intervals and recurrence periods. The results indicated that the GPR model is consistent with the GR model for intermediate-magnitude earthquakes. However, this coherence between the models is not valid for big earthquakes (Mw ≥ 7). According to the GR and GPR models, the return period of a magnitude 7 earthquake is 106.83 and 94.0347 years, respectively. The models used in the study confirm the expected and Pazarcık and Elbistan earthquakes on 6 February, 2023 because this region had not produced a magnitude 7 earthquake since 1893.
Anthelmintic evaluation of three Ayurvedic formulations: a transmission electron microscopy study in Raillietina sp. (Cestoda)
Authors: Chen Risa Parkordor , Soren Amar Deep , Yadav Arun Kumar
Published: July 2023

Ayurveda is one of the ancient traditional medicine systems in India. However, several Ayurvedic medicines lack scientific evidence about their efficacy. This study reports the in vitro anthelmintic effects of three common Ayurvedic formulations, Krimimudgar Ras, Kriminol, and Birangasav on a poultry cestode Raillietina sp., using transmission electron microscopy (TEM). Adult cestodes were exposed to different concentrations of Ayurvedic formulations and the paralysed parasites from the highest concentration (50 mg/ml) of Ayurvedic formulations, the reference anthelmintic praziquantel (PZQ) together with control were picked up and processed for TEM. The TEM studies of control cestode parasites revealed a normal arrangement of microthrix layer, basal lamina, longitudinal muscle layer, and a normal nucleus and mitochondria. Importantly, the cestodes that were exposed to 50 mg/mL concentration of Krimimudgar Ras revealed the most prominent ultrastructural alterations in the body of parasites in the form of a disrupted microthrix layer, basal lamina, muscle layer and mitochondria. The nucleus also appeared dense and irregular in shape with scattered chromatin and disrupted nuclear membrane. Kriminol-treated worms revealed considerably less damage, whereas Birangasav-treated worms revealed destructive effects in microthrix layer, nucleus and mitochondria. Through the findings of the present study, it can be concluded that of the three common Ayurvedic formulations studied, Krimimudgar Ras causes maximum degree of internal alterations in cestode parasites and thus may be considered as a good anthelmintic agent.
High-fat Diet Enhances the Growth of Renal Cell Carcinoma and Alters Immune Cells in Spleen, Kidney and Tumor
Authors: Zheng Zi Run , Ma Ke , Meng Yu
Published: July 2023

Renal cell carcinoma (RCC) is strongly associated with abnormal or excessive fat deposition in the body, whose processes include persistent adipose inflammation and other disturbances with the development and function of immune cells. Researchers have recently become more and more interested in understanding how high-fat diet (HFD) affects the development and course of RCC by causing immunological dysfunction. The changes of immune cell groups in RCC, particularly those in normal kidneys and tumors, are, nevertheless, still poorly understood. Consequently, we explore the effect of HFD on the changes of immune cell groups in spleens, normal kidneys and tumors, mainly revealing the changes of T cells, B cells and NK cells, and further preliminarily exploring the changes of NK cell phenotype. Our findings demonstrate that: 1) HFD speeds up the growth of ACHN tumors; 2) HFD increases the frequency of CD45+live cell, T cell and cNK in spleen, increases the frequency of T cell, NK cell and cNK in normal kidney, as well as increases the frequency of CD45+live cell, NK cell and cNK in tumor;3) HFD decreases the frequency of B cell, NK cell and ILC1 in spleen, decreases the frequency of CD45+live cell, B cell, and ILC1 in normal kidney, as well as decreases the frequency of T cell, B cell and ILC1 in tumor. These data will open up new avenues for immunotherapy in individuals with obese renal cell carcinoma.
Understanding Shifting Paradigms of Translation Studies in 21st Century
Authors: Ali Ghulam , Ali Nusrat , Syed Kazim
Published: July 2023

The study primarily aims at exploring the emerging trends and tendencies; and shifting paradigms in the field of translation studies in the twenty-first century. It also attempts to interpret the emergent tendencies in the field with reference to the present-day technological world. To investigate this shift, it analyzed the literature published on the phenomenon of translation between 2001 and 2022 in the Web of Science (Core Collection). It employs the software tools VOSviewer, Biblioshiny, ScientoPy, and MS Excel, this study seeks to visualize and analyze the data to gain insights into the dominant trends and themes related to translation and its role in cultural dialogue, politics, manipulation, mutual understanding, identity, cultural harmony, representation, discourse, ideology, cultural communication, language, and linguistic. The study after a comprehensive and systematic exploration of massive data found that the phenomenon of translation has undergone a profound metamorphosis, transcending the boundaries of traditional cultural paradigms to embrace the nascent realm of emerging technological paradigms. This paradigm shift has been propelled by groundbreaking advancements in machine translation, neural networks, natural language processing (NLP), and machine learning, heralding a seismic revolution within the translation industry. The fusion of technology and translation has not only redefined the very fabric of translation methodologies but has also exerted a transformative influence on the indispensable skills demanded from experts and scholars.
Respective contributions of intracranial and extracranial injuries in early coagulopathy occurrence following traumatic brain injury.
Authors: Wildenberg Lucille , Rustin Mathilde , Kallout Julien , Moyer Jean-Denis , Esnault Pierre , Pissot Matthieu , Godier Anne , Hanouz Jean-Luc , Geeraerts Thomas , Garrigue Delphine , Léone Marc , Legros Vincent , Audibert Gérard , Clavier Thomas , Abback Paer Sélim , Harrois Anatole , Figueiredo Samy , Group Traumabase
Published: July 2023

Background Following traumatic brain injury (TBI), coagulopathy on hospital admission is reported in 25–35% of patients and associated with increased morbimortality. The respective contributions of intracranial injury and concomitant extracranial lesions to coagulopathy have been poorly investigated. We hypothesized that the occurrence of post-TBI coagulopathy would not only be related to head injury severity, but also and to a greater extent to the presence and severity of the associated extra-cranial injuries.Methods Observational study from a multicenter prospective French trauma registry (Traumabase®). All adult patients directly admitted to one of the participating centers from January 2012 to December 2021 following TBI (AIS (Abbreviated Injury score) head ≥ 1) were included. Post-TBI coagulopathy was defined by at least 1 of the following criteria: prothrombin ratio (Quick %) < 70% or platelet count < 100 G.L− 1 or fibrinogenemia < 1.5 g.L− 1 on hospital admission. Severe associated extracranial lesions were defined by at least 1 of the extra-head AIS scores ≥ 3.Results Among 33875 patients admitted to 22 trauma centers, 9610 patients had TBI and were analyzed. The overall incidence of admission coagulopathy was 28.5%. Coagulopathic patients were significantly more severely injured and especially more severely head-injured, when compared to non-coagulopathic patients. The higher the AIShead, the higher the proportion of patients exhibiting coagulopathy (P < 0.001), whatever the presence of extracranial lesions. When compared to patients with AIShead = 1, the increased incidence of coagulopathy with TBI severity was observed at an earlier stage of TBI severity when severe extracranial lesions were present. In multivariable analysis, severe extracranial injury was independently associated with the risk of post-TBI coagulopathy (OR 2.0 (1.8–2.3), P < 0.001).Conclusions A continuously graded association between the severity of head injury and coagulopathy at hospital admission was observed, and this increased incidence of coagulopathy was observed at an earlier stage of TBI severity when severe extracranial lesions were present. The presence of severe extracranial injuries was one of the most important risk factors for coagulopathy following TBI. Intracranial and extra-cranial injury severity could be used to timely identify TBI patients most likely to present post-traumatic coagulopathy, that could benefit from early specific hemostatic resuscitation.
Direct spatiotemporal manipulation mechanism to generate spatiotemporally coupled ultrafast light fields
Authors: Xu Shixiang , Lin Qinggang , Feng Fu , Cai Yi , Lu Xiaowei , Zeng Xuanke , Wang Congying , Li Jingzhen , Yuan Xiaocong
Published: July 2023

Manipulation of spatiotemporally coupled (STC) light fields has gathered considerable interest over the last decade. The manipulation is generally performed in spectrum-space domain rather than time-space domain for the Fourier correlated natures of the time and spectrum domains because ultrafast light fields evolve so rapidly that no light modulator can keep pace with them. Spectrum-space manipulation using a 4-f pulse shaper has proved particularly successful, but suffers from limited spectral and pixel resolutions, plus information crosstalk from the spectral modulation in spectrum-space plane. To overcome these flaws, an innovative mechanism is proposed for direct time-space manipulation of an ultrafast light field, which involves introducing a space-dependent time delay and then performing spatial manipulation by a geometrical transformation. As an experimental verification, based on this mechanism, a high-quality STC light spring has been experimentally generated with a topological charge bandwidth as broad as 11.5 and a tunable central topological charge from 2 to − 11. Furthermore, the light spring can propagate with a stable spatiotemporal intensity structure and a basically invariant rotation period from the near field to the far field, which is critically important for its further manipulation and applications. This work provides an efficient way to generate complex spatiotemporal beams such as light springs, which have applications including information encryption, optical communication, and laser-plasma acceleration.
TiO 2 Coated SiO 2 Core-Shell Stationary Phase with Uniform and Tunable TiO 2 Thickness for High Performance Liquid Chromatography Separation
Authors: Wang Jiafei , Wan Xiang , Li YingYing , Mangelings Debby , Xie Fazhi , Huang Xianhuai , Li Weihua , Zhao Donglin , Qu Qishu
Published: July 2023

In this work, TiO2 was coated into the pores of the SiO2 core-shell spheres by using tetrabutyl orthotitanate (TBOT) as the titanium source. Then, by simply prolonging the reaction time, a TiO2 layer with a uniform and controllable thickness was obtained on the surface of SiO2 core-shell spheres by Ostwald ripening. The thickness of the TiO2 layer can be tuned from 15 to about 71 nm by either controlling the reaction time or controlling the amount of TBOT. C18-derived core-shell spheres with a TiO2 layer thicknesses of 40 nm (C18-SST-0.5-60) and 70 nm (C18-SST-0.7-30) were used as packings to evaluate the effect of TiO2 layer thickness on the chromatographic separation performance. The separation efficiency of C18-SST-0.5-60 and C18-SST-0.7-30 for fluorene was 115112 plates m− 1 and 83189 plates m− 1, respectively. Both TiO2-coated core-shell packings showed good peak symmetry for basic samples, with peak asymmetry factors below 1.11. The relative standard deviations of the retention time of polycyclic aromatic hydrocarbons and anilines were all lower than 6%. The results demonstrate that the TiO2 based stationary phase possesses great potential for high performance liquid chromatographic separation.
Incidence and risk factors of inguinal hernia after robot-assisted radical prostatectomy: a retrospective multicenter cohort study in Japan (the MSUG94 group)
Authors: Toide Masahiro , Ebara Shin , Tatenuma Tomoyuki , Ikehata Yoshinori , Nakayama Akinori , Kawase Makoto , Sasaki Takeshi , Yoneda Tatsuaki , Sakaguchi Kazushige , Teishima Jun , Makiyama Kazuhide , Kitamura Hiroshi , Saito Kazutaka , Koie Takuya , Inoue Takahiro , Urakami Shinji , Koga Fumitaka
Published: July 2023

Purpose: To investigate the incidence and risk factors of inguinal hernia (IH) after robot-assisted radical prostatectomy (RARP) using a multicentric database.
Methods: The present study used a multicentric database (the MSUG94) containing data on 3,195 Japanese patients undergoing RARP between 2012 and 2021. Surgical procedures utilized for IH prevention were as follows: isolation of the vas deferens, transection the vas deferens, isolation of the spermatic vessels, and separation of the peritoneum from the internal inguinal ring. The primary and secondary endpoints were IH-free survival and any association between post-RARP IH and clinical covariates. The prophylactic effect of the above procedures were also assessed.
Results: IH prevention was attempted in 1,465 (46.4%) patients at five of the nine hospitals. During follow-up (median 24 months), post-RARP IH developed in 243 patients. The post-RARP IH-free survival rate at year 1, 2, and 3 was 94.3%, 91.7%, and 90.5%, respectively. Old age (hazard ratio [HR]: 1.037; 95% confidence interval [CI]: 1.014-1.061; p = 0.001), low BMI (HR: 0.904; 95% CI: 0.863-0.946: p <0.001), and low hospital volume (HR: 1.385; 95% CI: 1.003-1.902; p = 0.048) were independently associated with IH development. None of the procedures for IH prevention were associated with IH development.
Conclusion: Our findings may represent the current, real-world status of post-RARP IH in Japan. The prophylactic effects of the surgical procedures for IH prevention should be further investigated in well-designed, prospective studies to optimize the surgical technique.
Phase segregation in La-doped YIG: Influence of temperature
Authors: Souza F. R. , Tavares E. L. , Soares João M. , Silva R. B. da , Peña-Garcia R. , Padrón-Hernández E.
Published: July 2023

Herein, we present a study about the calcination temperature effect on the structural and magnetic properties of the Y3Fe5-xLaxO12 compound. The refinement of the X-ray diffraction patterns confirmed the YIG single phase formation for sample calcined at 900°C, while for the samples sintered at 1000°C and 1100°C, it was verified the phase segregation belonging to the YFeO3 compound. The average crystalline size increases with the temperature, which may be related to the nucleation and growth mechanisms that are favored by temperature. The samples have an agglomerated morphology and an irregular elongated shape. The magnetic properties show variation in the magnetic moment of the compound as the phase formation temperature increases. At temperatures of 1000°C and 1100°C, the effects of the secondary phase are added to the magnetism of the compound, causing variations in the saturation magnetization and in the effective anisotropy field.
Comparison between intra-lesional steroid injection versus autologous platelet-rich plasma therapy following surgical excision of aural keloid (Difference in effectiveness of intra lesional steroids and PRP for aural keloid treatment)
Authors: Awan Nukhbat ullah , Fida Tooba , Waheed Khadija , FCPS Uzma Malik , Aslam Ayesha , Mehmood Khansa , ul Zain , Sadiq Sauban Mansoor
Published: July 2023

Background: Keloids are benign growth of dense fibrous tissues from an abnormal healing response to a cutaneous injury, extending beyond the original borders of the wound. Intralesional triamcinolone acetonide (TA) is their first-line therapy, but commonly associated with side effects or recurrence. Platelet rich plasma (PRP) is an autologous blood-derived product with promising results in improving wound healing with lower keloid occurrence.Objective:To compare the efficacy of TA versus PRP in treatment of Aural keloid after excision.Place and Duration of Study:The department of Ear, Nose and Throat and Head and Neck Surgery, King Edward Medical University, Mayo Hospital, Lahore, from January 2021 to October 2021.Study Design:Randomized controlled trialMethods:Patients with aural keloids type I and II were enrolled in the study. 84 patients with aural keloids were divided randomly into two equal groups, A and B. Patients with aural keloids only type I and type II (acc. To Chang Park classification) and Patients without prior treatment were included and those presenting with Hypertrophic scars, Type III, IV, V (in accordance to Chang Park classification) and Pregnancy were excluded in our study. Group A received intralesional TA (20 mg/ml) after excision for 4 sessions, first on the day of surgery rest 3 sessions 1 week apart. Group B patients received intralesional PRP after excision in 4 sessions similar to TA. Evaluation was done after 3 months by The Patient and Scar Observer Assessment Scale (PSOAS).ResultsOf the 84 patients included in our study all 84 were females, having mean age around 22-23 years with 72% of them being unmarried. The mean scores of POSAS Patient scale for pain was found to be 15.65 in grp A and 27.23 in grp B, with color having mean score of 19.76 (grp A) and 27.24 (grp B), itching 19.5 (grp A) and 27.8 (grp B), stiffness 19.83 (grp A) and 27.8 (grp B), thickness 19.36 (A) and 28.81 (B), irregular scar 19.47 (A) and 27.3 (B). There was statistically significant improvement in all parameters of PSOAS of group B patients with their mean consistently being lower than group A patients i.e those receiving TA. Both groups had similar complications which were minor with hyperpigmentation being most of it all.Conclusion:We concluded that PRP is superior in preventing recurrence of aural keloid after surgical excision.
Inter-plot competition in hybrid maize multi-environment yield trials in Ethiopia can reduce rate of genetic gain
Authors: Keno Tolera , Mace Emma , Godwin Ian , Jordan David , Kelly Alison
Published: July 2023

Conducting large-scale multi-environment trials (METs) is practically challenging to breeding programs in Sub-Saharan Africa due to limitations of land, seed, and associated costs of phenotyping. As a result, early-generation hybrid maize trials are usually planted with single-row plots. In trials with single-row plots, genotypes compete with their neighbors for resources, and this biases the prediction of the genotype value. We demonstrate the impact of inter-plot competition in single-row multi-environment hybrid maize trials in Ethiopia through a motivating example assessing subsets of 478 maize hybrids in six trials in the 2019 and 2020 main season. The trials were planted in partially replicated design with single-row plots. Field spatial variability and inter-plot competition were jointly modelled in a linear mixed model framework to partition the total genetic effect into direct and neighbour effects. Both direct and neighbour genetic effects differed across the trials confirming the presence of genotype by environment interaction (GEI) for these genetic components. There was a rank change in genotype performance between the selections from the competition model in comparison to the standard MET model. The proportion of mismatch in the top 20% of the selected genotypes from the competition model and the standard MET model ranged from 20 – 70 % across the optimum nitrogen sites and up to 90 % in the low nitrogen site. The results demonstrated that inter-plot competition biases grain yield predictions in single-row plot hybrid maize METs and thus reduces the rate of genetic gain, if not accounted for using appropriate statistical models.
ARPC3 affects the prognosis of patients with hepatocellular carcinoma by regulating the immune response
Authors: Song Yonghu , Li Jianhui , Lu Zhenyang , Qi Yijun
Published: July 2023

Background
ARPC3 is associated with poor prognosis in patients with various cancers. However, the mechanisms by which it affects immunotherapy and prognosis in patients with hepatocellular carcinoma (HCC) remain unclear.
Method
The expression difference in ARPC3 between normal and HCC tissues and the effect of ARPC3 on prognosis were evaluated by using multiple databases. GSEA was used to predict the pathway by which ARPC3 affects HCC progression. Using TCGA database, the First Affiliated Hospital of Anhui Medical University (AHMU) database and ICGC database, the correlation between ARPC3, tumor infiltrating lymphocytes (TILs) and immune checkpoints was studied. To explore the effect of ARPC3 on immune checkpoint inhibitors (ICIs), We investigated the association of ARPC3 with immunotherapy-associated ferroptosis genes.
Results
The expression of ARPC3 in normal tissues was lower than that in tumor tissues, and as an independent prognostic risk factor for HCC, patients with HCC whose ARPC3 expression was high had a worse prognosis. GSEA suggested that the upregulation of ARPC3 mainly affected immune-related pathways. Three databases showed that ARPC3 expression levels affected the infiltration levels of B cells, T cells, macrophages, neutrophils, and NK cells in tumors. In addition, we confirmed that ARPC3 may influence the efficacy of ICI therapy by influencing the expression of immune checkpoints and ferroptosis-related genes in HCC.
Conclusions
ARPC3 is an independent prognostic risk factor for HCC patients and may influence the immunotherapy of HCC by influencing the expression of immune checkpoints and ferroptosis-related genes.
The distal resection of the rectal pouch in laparoscopic-assisted anorectoplasty for males with anorectal malformation: 153 cases’ experience in a single center
Authors: ye shiru , Zhou Yan , Zheng Chen , Li Siqi , Hu Wenshu , Gao Ruyue , Diao Mei , Li Long
Published: July 2023

Purpose This study aimed to evaluate the factors associated with constipation and the efficacy of the distal resection length (DRL) of not less than 3cm in males with anorectal malformation (ARM).
Methods Demographic, associated anomalies, clinical features, and the bowel function of the males with ARM and rectourethral/rectovesical fistula (RUF/RVF) were evaluated. The Krickenbeck scores were used to assess bowel function. Univariate and multivariate analysis were used to identify factors associated with constipation. The bowel function was evaluated between the groups categorized by DRL after 1:1 propensity score matching (PSM).
Result A total of 153 males with a median follow-up period of 6 years, 54(35.2%) suffered from constipation. Multivariate analysis revealed that the DRL (OR = 0.68, P = 0.007) is the only independent protective factor of constipation after potty training. After PSM, 35 patients were included in each of the groups categorized by DRL≥3.0cm and DRL＜3cm, and the patients were well-balanced. No significant differences between groups were noted in postoperative complications (11.4% vs. 25.7% P = 0.218) and constant soiling (17.1% vs. 31.4%, P = 0.718). However, the incidence of constipation in the DRL≥3.0cm group was significantly lower than that in the DRL＜3cm group(37.1% vs. 71.4%, P = 0.028).
Conclusion The longer distal resection was the independent protective factor for constipation, suggesting that the excessive preservation of the rectal pouch is the cause of constipation. And the constipation rate in ARM with DRL ≥3cm was significantly lower without increment of soiling after PSM, which may be associated with the fibrosis in the last 3cm of the rectal pouch. Thus, not less than 3cm of the rectal pouch is recommended to resect in males with ARM.
A window-based multi-scale attention model for slope collapse detection
Authors: Pan Yuchen , Xu Hao , Qian Kui , Li Zhenyan , Yan Hong
Published: July 2023

Slope collapse detection is a critical foundation for defending against water flow impact and maintaining shoreline stability. Under realistic detection conditions such as difficult collection of actual defect samples and complex target environment, addressing the problem of existing deep learning techniques with low recognition accuracy, a window-based multi-scale attention model for slope collapse detection called Faster-Swin is proposed. The traditional convolutional neural network (CNN) architecture has been enhanced by incorporating skip connection structures such as Elan block and SPPC block, which alleviate the problem of gradient vanishing that arises from increasing depth in deep neural networks. Then the window-based multi-scale attention mechanism is added to the backbone network to increase the overall modeling ability of the model and reduce the computational cost. Experimental results show that Faster-Swin can adapt to complex backgrounds in low-quality datasets, and the final mean average precision (map) value can reach 97.16\%
A Novel Approach To The Transformation of Pyrazole-4-Carbonitriles to Novel 3-Aryl-1-Phenyl-1H-Pyrazole-4-Carbothioamide Using Thioacetamide as a Sulfur Source
Authors: Choudhare Tukaram S. , Wagare Devendra S. , Pawar Sangita , Netankar Prashant
Published: July 2023

New protocol designed for the synthesis of novel pyrazole-4-carbothioamide by the reaction of pyrazole-4-carbonitrile using thioacetamide in the presence of Amberlyst-15 as a catalyst in ethanol. Various methods are adopted for the synthesis of 3-Aryl-1-phenyl-1H-pyrazole-4-carbothioamides such as Amberlyst-15 method, Citric acid method, BF3-Etherate method and Dowex DR-2030 method. But Amberlyst-15 method offered highly pure product with excellent yield. Here, thioacetamide employed as sulfur source and avoid use of hazardous Lawesson’s Reagent, Na2S, H2S gas. Novel Pyrazole-4-Carbothioamides are synthesized and characterized by using 1H NMR, 13C NMR and Mass spectral techniques. It’s a rapid, single step and clean synthetic protocol for the synthesis of Pyrazole-4-carbonitriles with excellent yield (97-99%).
Novel Synthesized Ionizable Lipid for LNP-mediated P2X7siRNA Inhibit Migration and Induce Apoptosis of Breast Cancer Cells
Authors: Kiaie Seyed hossein , Zangi Ali Rajabi , hemmati Salar , Baradaran Behzad , Valizadeh Hadi
Published: July 2023

The development of ionizable lipid (IL) was necessary to enable effective formulation of small interfering RNA (siRNA) to inhibit P2X7 receptors (P2X7R), a key player in tumor proliferation, apoptosis, and metastasis. In this way, the generation and utility of IL for enhancing cellular uptake of lipid nanoparticles (LNP) improves the proper delivery of siRNA-LNPs for knockdown overexpression of P2X7R. In this study, we synthesized a branched ionizable lipid (SIL) that efficiently transfects LNP with P2X7 siRNA (siP2X7) for evaluation of BC migration and apoptosis in mouse 4T-1 cells. Following synthesis and structural analysis of SIL, LNP was prepared with excellent characterization (Z-average 126.8 nm, Zeta-potential − 12.33, and PDI 0.16, and encapsulation efficiency 85.35%). Afterwards, the stability of the LNP was evaluated through an analysis of each leftover composition, and toxic concentration values for SIL and siP2X7 were determined. Furthermore, siP2X7-LNP cellular uptake in the formulation was assessed via confocal microscopy. We used scratch assay microscopy and flow cytometry to assess wound healing analysis and apoptosis after determining the optimal dose (45 pm). As a result, the formulated siP2X7-LNP with innovative SIL indicates that offbeat cellular uptake inhibits migration and induces apoptosis of 4T-1 cells. Subsequently, SIL plays a critical role in LNP formulation to deliver siRNA efficiently against murine triple-negative breast cancer cells (TNBC).with significant efficacy.
Virtual Reality in Health Sciences
Authors: Castrillon-Arias Cristian G. , Caicedo-Eraso Julio C. , Varon-Serna Diana R.
Published: July 2023

Technological innovations have provided contributions to different productive sectors, and in the field of medicine, their presence is increasingly relevant. They aim to improve the quality of services for patients by encompassing all aspects of healthcare, improving medical assistance, the overall health status of the population, and increasing life expectancy. This technological revolution affects the role of the doctor and their relationship with patients, creating a new way of practicing medicine. Technologies such as virtual reality and augmented reality demonstrate the various contributions they can provide in medicine. This work aims to provide the most important trends and technologies of virtual reality applied to the healthcare sciences and medical practice. Different medical technological solutions were analyzing and classified as three topics: prevention, diagnosis, and treatment.
Improving Emergency Response: An In-Depth Analysis of an ITS-G5 Messaging Strategy for Bus Blockage Emergencies at Level Crossings
Authors: Dardour Mayssa , Mosbah Mohamed , Ahmed Toufik
Published: July 2023

The Intelligent Transportation System protocol stack (ITS-G5/802.11p) has revolutionized traffic efficiency and road safety applications in vehicular environments. This study presents a novel architecture for communications, utilizing IPv4 mul-ticast over 802.11p/ETSI ITS-G5, which addresses the challenges of a specific urban use case involving a Level Crossing (LC) in Bordeaux. Our proposed architecture focuses on the broadcast of Cooperative Awareness Message (CAM) and Decentralized Environmental Notification Message (DENM) to enhance road user safety. To prevent accidents, an algorithm for CAM and DENM dissemination has been devised, ensuring timely alerts for sudden vehicle blockage emergencies. Moreover, a comprehensive and optimized train braking strategy is introduced to further minimize accident risks. This strategy aims to provide efficient and timely train deceleration, allowing sufficient time for road users to clear the level crossing and mitigating the potential for collisions. To evaluate the system’s performance , we analyze key metrics, including End-to-End (E2E) delay and Packet Reception Ratio (PRR). Furthermore, our work includes a comparative analysis between our proposed edge-server-based architecture and a cloud-based architecture. This analysis provides valuable insights into the strengths and weaknesses of each approach. Through comprehensive experimentation and evaluation, our proposed approach demonstrates its efficiency and effectiveness in mitigating accidents and enhancing road safety. By leveraging the capabilities of ITS-G5, our research contributes to the advancement of communication systems for intelligent transportation. The findings of this study provide a foundation for future 1 deployments and improvements in urban environments, fostering safer and more reliable transportation systems.
Semi-supervised Graph Convolutional Deep Embedded Clustering
Authors: Cao Chao , Li Mengli , Yang Shuhong , Li Chungui
Published: July 2023

Clustering is an important field of study in data analysis, and semi-supervised clustering, as a sub-category of clustering, has received extensive attention for significantly improving performance with only a small amount of prior information introduced. In recent years, many studies have incorporated semi-supervision into their field. Although good results have been obtained, most of these methods, when introducing additional information (for example, multi-view information), could not make full use of the given knowledge to mine the similarity in intra-class, and get performance not prominent enough. For this situation, we put forward a new method of Semi-supervised Graph Convolutional Deep Embedding Clustering (SGDEC), which is a single-view algorithm. Specifically, an autoencoder network (implemented by linear layers) is pre-trained, we innovatively propose to employ the GCN to learn the data similarity reflected by the prior information of the pairwise information, and make clear the training direction of the latent variable z. Clustering label assignment and feature representation can be optimized by clustering loss alone. Unlike previous methods that only use pairwise information as a constraint in neural network, this architecture can make full use of pairwise information and capture similarities from it, optimizing the entire network for better clustering performance. We conduct many experiments on four popular benchmark datasets of images using the same set of learning rates, and it is shown that our SGDEC achieves a significant improvement over the new single-view algorithms, even better than the latest multi-view methods.
Seismic Performance of Linked-Column Frame; Multi-Parameter Study
Authors: Jaya Ramadhansyah Putra
Published: July 2023

In the current research, the effect of length and number of link beams on the structural response of Linked-Column Frames (LCFs) with different heights has been studied and compared with Special Moment-Resisting Frames (SMRFs). To this aim, 34 LCFs of 3-, 6-, and 9-story with two or three links in story level were designed in ETABS and simulated in OpenSees. The beam length ranged between 1-3.5 m altering plastic behavior from shear to flexure. Nonlinear dynamic analysis was carried out using 20 numbers of far-field and near-field records from FEMA-P695 scaled to DBE and MCE seismic hazard levels. Results illustrated that increasing the length and number of links generally reduced seismic demands. However, conflicting trends were observed in shear-flexure cases producing the greatest drift ratio and lowest base shear at the same time. Also, near-field records maintained almost similar demands compared to the far-field set except for the significantly different base shear responses. The results of 3-story LCFs were more promising in terms of a larger reduction in demands compared to the same height SMRF; utilizing LCF reduced SMRF drift ratio up to 72% in 3-story, and almost 26% in 6- and 9-story structures. The desirability coefficient determined the most suitable configuration for link beams, suggesting three numbers of 1.5 m shear links for 3-story LCF, and 3 m intermediate links with 3 and 2 numbers for 6- and 9-story structures, respectively. In conclusion, LCF system is not economical for taller buildings due to the relative weight increase.
Assessing sustainability reporting of Indian infrastructure firms
Authors: Yadav Rakesh , Yadava Ram Nayan
Published: July 2023

This paper summarizes the arguments and counterarguments within the scientific discussion on the issue of Business sustainability. The main purpose of the research is to look at the quality of sustainability reports of Indian infrastructure firms and use scoring method from literary sources for solving the problem and the issue of Business sustainability. The relevance of this scientific problem decision is that it adds to the literature of sustainability of firms. Investigation of the topic in this paper is carried out by using the Global Reporting Index (GRI) framework viz., economic, environment and social factors Methodological tools of the research methods were scoring methods which has been used for decade by the researchers in this field of study. The object of research is the analysis of sustainability reports of Indian Infrastructure firm because this sector faces namely external business environment negativities in Indian context. The paper presents the results of an empirical analysis by comparing large, medium and small firms, which showed that difference inside the large, medium, small group of companies. We find support to the earlier researches that have shown, large companies report better sustainability scores more than smaller ones on sustainability reporting. The research empirically confirms and theoretically proves the resources based view of strategic management. The results of the research can be useful for policy makers who can promulgate better incentive and provide technical expertise to medium and small firms to enhance their sustainability reporting.
How far does the central bank influence its economies? The example of Algeria
Authors: Messaoudi Abdelkrim , Derbal Fatima Zohra , Hasnaoui Meriem , Belhamidi Hadjer
Published: July 2023

This study focused on Algeria and it looked at how education quality affected the knowledge economy. The theoretical anchor was the endogenous or new growth hypothesis. Secondary sources were used to get panel-structured data that spanned 48 Algerian provinces in 22 years (1999–2020). The equations were estimated using the fixed-random effect model and Hausman test, Also the Kao (Engle Ganger-based) cointegration test proved that the series did indeed have a long-run connection. The findings indicated that the knowledge economy was boosted by a rise in students’ Baccalaureate and Intermediate test success rates. This is due to the fact that a rise in exam success rates indicates that individuals at various educational levels are now receiving education of a higher caliber, and the economy depends on this caliber of education. The rise in students and professors is a sign that there are more knowledgeable people and specialized educators accessible to fuel the knowledge economy. As more educated citizens pass their exams and graduate from college, they are hired from the labor market into industries as significant production factors whose skills, values, and knowledge acquired through specialized training are expected to promote machine handling and coordination of other human and nonhuman production factors to fuel the knowledge economy. Teachers should be provided with ongoing professional development opportunities to help them provide instruction at all educational levels, according to a recommendation. This would improve their ability to educate and inspire students and help them do better on their intermediate and baccalaureate exams.