bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation
Authors: Sinatra Laura , Vogelmann Anja , Friedrich Florian , Tararina Margarita , Neuwirt Emilia , Colcerasa Arianna , König Philipp , Toy Lara , Yesiloglu Talha , Zhang Lin , Einsle Oliver , Sippl Wolfgang , Groß Olaf , Bendas Gerd , Christianson David , Hansen Finn , Jung Manfred , Schiedel Matthias
Published: July 2023

Dysregulation of both tubulin deacetylases sirtuin 2 (Sirt2) and the histone deacetylase 6 (HDAC6) has been associated with the pathogenesis of cancer and neurodegeneration, thus making these two enzymes promising targets for pharmaceutical intervention. Herein, we report the design, synthesis, and biological characterization of the first-in-class dual Sirt2/HDAC6 inhibitors as molecular tools for dual inhibition of tubulin deacetylation. Using biochemical in vitro assays and cell-based methods for target engagement, we identified Mz325 (31) as a potent and selective inhibitor of both target enzymes. Inhibition of both targets was further confirmed by x-ray crystal structures of Sirt2 and HDAC6 in complex with building blocks of 31. In ovarian cancer cells, 31 evoked enhanced antiproliferative effects compared to single or combination treatment with the unconjugated Sirt2 and HDAC6 inhibitors. Thus, our dual Sirt2/HDAC6 inhibitors are important new tools to study the consequences and the therapeutic potential of dual inhibition of tubulin deacetylation.
The Challenge of Balancing Model Sensitivity and Robustness in Predicting Yields: A Benchmarking Study of Amide Coupling Reactions
Authors: Liu Zhen , Moroz Yurii S. , Isayev Olexandr
Published: July 2023

Accurate prediction of reaction yield is the holy grail for computer-assisted synthesis, but current models have failed to generalize to large literature datasets. To understand the causes and inspire future design, we systematically benchmarked the yield prediction task. We carefully curated and augmented a literature dataset of 41,239 amide coupling reactions, each with information on reactants, products, intermediates, yields, and reaction contexts, and provided 3D structures for the molecules. We calculated molecular features related to 2D and 3D structure information, as well as physical and electronic properties. These descriptors were paired with 4 categories of machine learning methods (linear, kernel, ensemble, and neural network), yielding valuable benchmarks about feature and model performance. Despite the excellent performance on a high-throughput experiment (HTE) dataset (R2 around 0.9), no method gave satisfying results on the literature data. The best performance was an R2 of 0.395 ± 0.020 using stack technique. Error analysis revealed that reactivity cliff and yield uncertainty are the main reasons for incorrect predictions. Removing reactivity cliffs and uncertain reactions boosted the R2 to 0.457 ± 0.006. These results highlight that yield prediction models must be sensitive to the reactivity change due to the subtle structure variance, as well as be robust to the uncertainty associated with yield measurements.
Application of an Oscillatory Plug Flow Reactor to Enable Scalable and Fast Reactions in Water Using a Biomass-Based Polymeric Additive
Authors: Hammer Susanne , Nanto Filippo , Canu Paolo , Otvos Sandor B. , Kappe C. Oliver
Published: July 2023

The utilization of water as a sustainable reaction medium has important advantages over traditional organic solvents. Hydroxypropyl methylcellulose has emerged as a biomass-based polymeric additive that enables organic reactions in water through hydrophobic effects. However, such conditions imply slurries as reaction mixtures, where the efficacy of mass transfer and mixing decreases with increasing vessel size. In order to circumvent this limitation and establish an effectively scalable platform for performing hydroxypropyl methylcellulose-mediated aqueous transformations, we utilized oscillatory plug flow reactors that feature a smart dimensioning design principle across different scales. Using nucleophilic aromatic substitutions as valuable model reactions, rapid parameter optimization was performed first in a small-scale instrument having an internal channel volume of 5 mL. The optimal conditions were then directly transferred to a 15 mL reactor, achieving a three-fold scale-up without re-optimizing any reaction parameters. By precisely fine-tuning the oscillation parameters, the system achieved optimal homogeneous suspension of solids, preventing settling of particles and clogging of process channels. Ultimately, this resulted in a robust and scalable platform for performing multiphasic reactions under aqueous conditions.
Towards a Stochastic Complete Active Space Second Order Perturbation Theory
Authors: Safari Arta A. , Li Manni Giovanni , Anderson Robert J.
Published: July 2023

In this work an internally contracted Stochastic Complete Active Space Second Order Perturbation Theory, Stochastic–CASPT2, is reported. The method relies on stochastically sampled reduced density matrices (RDMs) up to rank four and con- tractions thereof with the generalized Fock matrix. A new protocol for calculating higher–order RDMs in FCIQMC has been designed based on: (1) restricting sampling of the corresponding excitations to a deterministic subspace, (2) averaging the RDMs from independent dynamics and (3) projecting the resulting RDMs onto the closest positive semi-definite matrix. Our protocol avoids previously encountered numerical conditioning problems stemming from numerical noise in the orthogonalisation of the perturber overlap matrix. The Chromium dimer CASSCF(12,12)/CASPT2 binding curve is computed as a proof of concept.
Combined Electrocatalytic Oxidation and Reduction to Selectively Cleave β-O-4 Linkage of Lignin over Platinum Electrode in Organic Solvent: Secondary treatment opportunity for CELF Process
Authors: Hasan Mahmudul , Akbari Amir , F. Greenlee Lauren
Published: July 2023

Valorization of lignin is gaining popularity due to its ability to make industrial processes more sustainable. However, the currently prevalent catalytic technologies use large amounts of energy and harsh reaction conditions. As a result, bonds between lignin precursors are cleaved unselectively, and the selectivity of aromatic products is reduced. An electrocatalytic approach may allow improved control, and few studies have assessed electrocatalytic oxidation and reduction of lignin in organic solvents. Organic solvents like tetrahydrofuran (THF) are of interest for lignin electrocatalysis due to their use in the cosolvent enhanced lignocellulosic fractionation (CELF) process. The CELF process has the ability to overcome biomass recalcitrance by breaking β-O-4 aryl ether interunit linkages. Using electrocatalytic conversion processes, additional β-O-4 interunit linkages can be broken down selectively. As a result, if these two processes are integrated, a high amount of phenolic hydroxyl groups with low content aryl ether linkages will be produced, making the product suitable for development of biofuels and other chemicals. This study shows that by using controlled electrocatalytic oxidation and reduction in THF/aqueous acidic electrolytes in the ratio of 2:1, nonpolar β-O-4 linkages can be cleaved. This ratio was chosen to mimic the electrolyte composition environment of the CELF pretreatment. The results from both ATR-IR and NMR characterization are consistent and show that β-O-4 interlinkage bonds were broken. Quantitative calculations from NMR show that during oxidative potential holds, the presence of aromatic compounds increased by 28.67% and aliphatic compounds decreased by 32.73%. On the other hand, during reductive potential holds, the presence of aromatic compounds decreased by 33.50% and aliphatic compounds decreased by 78.43%. These results indicate that electrooxidation and electroreduction may be used strategically to cleave interunit linkages. Thus, if electrochemical degradation of lignin is used as a secondary treatment in conjunction with the CELF process, it will greatly increase the possibility of transforming lignin into value-added products.
A Proposed Service Quality Measurement Model using Sentiment Analysis and Text Mining: The Case of Water and Sewerage Services
Authors: SUR Erhan , ÇAKIR Hüseyin
Published: July 2023

This study proposes a new model for service quality measurement using sentiment analysis and text mining techniques. This model aims to overcome traditional methods' time, cost and implementation difficulties and provide a more dynamic and efficient approach to service quality measurement. In addition, in this model, instead of the dimensions used in service quality measurements, such as SERVQUAL or SERVPERF, it is shown how to determine new categories and keywords specific to the service sector in which the model is used by text mining. Thus, it is aimed at something other than reaching more accurate results in service quality measurement. To achieve the model’s purpose, it aims to develop a service quality measurement model using social media data processed by text mining and sentiment analysis. To find an answer to this question, the keywords "flood", "meter", "rain", "irrigation", "infrastructure", "sewerage", "sewage", "maintenance hole ", "aski", "waterless", "water" were extracted from 109.844 tweets sent to the Twitter account of a municipality between 2016 and 2022 by text mining method. Service quality was measured by subjecting 5766 tweets containing the keywords extracted to sentiment analysis. As a result of the service quality measurement, 1922 negative, 973 positive and 2871 neutral tweets were identified. The average negative score was 0.51, the average positive score was 0.11, and the average neutral score was 0.38.
Implementasi Mahram Dalam Pelaksanaan Haji Bagi Perempuan Perspektif Maṣlaḥah (Studi Kasus pada Penyelenggaraan Haji di Kementerian Agama Kota Makassar)
Authors: Bobihu Muhaimin
Published: July 2023

Dalam pelaksanaan ibadah haji, pihak Arab Saudi mewajibkan adanya mahram bagi jama’ah haji perempuan, namun memberikan kebijakan kepada jama’ah yang berusia 45 tahun ke atas untuk dapat melaksanakan haji walau tidak disertai mahram. Padahal ‘illah penyertaan mahram dalam perjalanan bagi perempuan adalah untuk keamanan. Fenomena ini dapat dianalisis dengan metode maṣlaḥaḥ yang dapat digunakan untuk menetapkan suatu hukum yang belum diatur secara rinci dan jelas di dalam Al-Quran dan hadis agar dapat diambil suatu hukum sesuai pandangan syariat. Penelitian jenis field research kualitatif ini menggunakan pendekatan yuridis dan normatif. Data dikumpulkan melalui tiga teknik yakni observasi partisipasi, wawancara mendalam, dan penggunaan dokumen. Data dianalisis dengan 3 tahapan, yakni reduksi data, display data, dan penarikan kesimpulan. Hasil menunjukkan bahwa untuk penyelenggaraan haji di Kementerian Agama Kota Makassar tahun 2015-2019 termasuk dalam kategori Al-Maṣlaḥaḥ al-Ḥājiyyah dimana bagi perempuan yang ingin berangkat haji tanpa mahram akan tetap diberangkatkan dan dimahramkan dengan mahram fungsional atau penggabungan mahram, karena keberangkatan haji dinilai jauh lebih penting daripada ketentuan mahram yang tercantum dalam matan-matan hadis dan karena keamanan sudah terjamin dengan adanya transportasi yang canggih, fasilitas yang memadai, dan adanya jama’ah lain serta pemandu (mutawwif) yang dianggap sudah menjamin keamanan perempuan.Kata kunci: Haji, Implementasi Mahram, Maṣlaḥaḥ
Youth perception towards entrepreneurial ecosystem in bangladesh: A deep diving investigation through in-depth interviews
Authors: MD. Mokarremul Hoque Helal Mridha , MD. Kamruzzaman
Published: July 2023

The entrepreneurial ecosystem and its factors are mandatory for entrepreneurship development. A congenial ecosystem creates a positive perception among potential entrepreneurs. Every year, youths in tertiary education in Bangladesh graduate and pursue a limited number of jobs, resulting in many of them being left unemployed. Therefore, a substitute for a job is required, which can be achieved through entrepreneurship development. It necessitates a congenial ecosystem. Thus, this study aims to investigate the perception of youth towards the entrepreneurial ecosystem in Bangladesh. The study is based on twenty-two in-depth interviews with youth studying in tertiary education. The findings reveal that the perception of the factors in the entrepreneurial ecosystem is not very positive. However, most of the interviewees admitted that they are not well aware of the existing factors in the entrepreneurial ecosystem and have simply expressed their inferences.
Research on the Reform of the Course “Reading of Concrete Structure Plan and Construction Drawings” Under the Background of “Promoting Teaching and Learning Through Competitions”
Authors: Yu Guixiang , Tan Xiaolong
Published: July 2023

The inherent teaching approach can no longer meet the demands of society. In this paper, current issues within the teaching landscape of architectural engineering technology in higher vocational colleges as well as the policies and teaching demands that formed the basis of this model were analyzed. The study shows the importance of the implementation of the teaching model “promoting teaching and learning through competitions.” This model puts emphasis on the curriculum and teaching resources, while also integrating the teaching process and evaluation with competition. These efforts aim to drive education reform in order to better align with the objectives of vocational education personnel training, while also acting as a reference for similar courses.
Analysis on the Characteristics and Laws of Tunnel Hydraulic Inrush in Karst Area
Authors: Wang Xingxing , Wu Senyang , Dai Donglin
Published: July 2023

As highways are extended to deep mountains, high altitudes, and special geological conditions, tunnel construction becomes more and more challenging, especially the construction of tunnels in karst areas. Due to the particularity of the regional geological structure, karst is well developed in the southwest of our country, especially at areas where the problem of tunnel water inrush in karst areas is more prominent. To further ensure the safe construction and operation of tunnels, the characteristics of tunnels in karst areas is analyzed in this article.
Pathogenesis, Rehabilitation Assessment, Treatment Status, and Research Progress of Vascular Dementia
Authors: Zhao Yaxi
Published: July 2023

Given the global trends in population aging, the prevalence of vascular dementia (VD) is increasing year by year. VD has become the second most common type of dementia and can seriously threaten the quality of life of patients. Since VD is preventable, it is important to study VD clinically in order to improve the prognosis of patients. In recent years, a large number of studies have been carried out at home and abroad, focusing on the pathogenesis, rehabilitation assessment, and treatment of VD. This article is a concise overview of these studies.
Methodological frameworks for adapting global practice guidelines to national context in the Eastern Mediterranean Region
Authors: Alshehri Abrar , Almazrou Saja , Amer Yasser
Published: July 2023

Background: Adapted clinical practice guidelines (CPGs) are based on existing recommendations from other developers. Aims: To produce a mapping summary of the methods used for adaptation of CPGs in the Eastern Mediterranean Region (EMR). Methods: We conducted a literature review of studies describing adaptation of CPGs in the EMR. Databases and official websites were searched for studies published between 2006 and 2022. We excluded de novo development of CPGs and adaptation of other types of guidelines such as public health guidelines. Results: As an overview of the current situation of CPG adaptation in the EMR, we identified the 2 main categories: informal and formal adaptation. Six formal adaptation frameworks were used in the EMR: ADAPTE, Adapted-ADAPTE, GRADE-ADOLOPMENT, RAPADAPTE, CAN-IMPLEMENT, and KSU-Modified-ADAPTE. The validation of adapted CPGs to the local context is not well defined in the literature. Conclusion: Despite the successful use of CPG formal adaptation frameworks, there is no international standardized guidance to identify which framework is most suitable for specific healthcare contexts in the EMR. Each institution has adapted its CPGs differently. A standardized selection tool is needed to enhance the appropriate selection of the adaptation method that fits the local resources and context. We encourage EMR countries and organizations to register their old and new CPG adaptation projects to avoid duplication in guideline synthesis.
APLICACIONES DE LA INTELIGENCIA ARTIFICIAL EN CONTRIBUCIÓN A LA DEFENSA NACIONAL DE CHILE. UNA OPORTUNIDAD PARA LA INTEGRACIÓN DE LA DEFENSA, LA INDUSTRIA Y LA ACADEMIA
Authors: Quiñones Sigala Manuel
Published: July 2023

APLICACIONES DE LA INTELIGENCIA ARTIFICIAL EN CONTRIBUCIÓN A LA DEFENSA NACIONAL DE CHILE. UNA OPORTUNIDAD PARA LA INTEGRACIÓN DE LA DEFENSA, LA INDUSTRIA Y LA ACADEMIA
SUPERPOTENCIAS DE LA INTELIGENCIA ARTIFICIAL: CHINA, SILICON VALLEY Y EL NUEVO ORDEN MUNDIAL
Authors: Pacheco González Tomás
Published: July 2023

SUPERPOTENCIAS DE LA INTELIGENCIA ARTIFICIAL: CHINA, SILICON VALLEY Y EL NUEVO ORDEN MUNDIAL
A Study on the Subjective Perception of Stakeholders on the Location of Waste Incineration Facilities
Authors:   The Korea Association Of Governance Studies, RYU DO-AM
Published: July 2023

This study aims to grasp the subjective perception of local residents in the midst of conflicts that arise in the process of constructing waste incineration treatment facilities. To this end, the Q methodology which is easy to grasp human subjective perception was used. Since the implementation of the local autonomy system conflicts over the location of non-preferred facilities have continued to arise in the region. With the revision of the Enforcement Rules of the Waste Management Act revised in 2021, each local government is speeding up the construction of waste incineration facilities to replace them. At this point conflicts over the location of waste incineration facilities may continue to increase and collective action by residents will also accelerate. As a result of the analysis of the study there were differences in the characteristics of respondents and the perspective of approaching incineration treatment facilities by type. In particular it was found that both the construction and operation of incinerators are important indicators of local resident's acceptance in terms of the location and operation of incinerators rather than the two aspects of approval and opposition. In addition it was suggested that it is necessary to establish a strategy to secure acceptability for local residents with stereotypes.
Análise de sensibilidade e calibração espacial do modelo SWAT aplicado em uma bacia do litoral pernambucano através de dados climáticos observados e de reanálise (Analysis of sensitivity and calibration of the SWAT model applied in a basin in northeast of Brazil using observed and reanalysis climatic data)
Authors: Vieira Rocha Nívia Cristina , Carvalho Mendes Amilcar
Published: July 2023

O município de Barcarena está localizado na margem direita do Rio Pará e abriga as praias de Caripi, Itupanema e Vila do Conde. Estas estão sob influência direta do complexo portuário ali existente, tendo as atividades socioeconômicas desenvolvidas no município, como potencialmente prejudicadas, caso ocorra derramamento de óleo nas águas que as bordejam. Esta pesquisa teve como objetivo avaliar a sensibilidade ambiental das referidas praias, ao derramamento de óleo, à erosão, e à urbanização. A metodologia adotada constou na combinação de dados pretéritos, aquisição e processamento de imagens GeoEye e levantamento de campo apoiado nas propostas voltadas a determinação da declividade, dos níveis de erosão e de urbanização e identificação dos índices de sensibilidade ambiental. Como principais produtos foram gerados mapas de índices de sensibilidades das áreas em escala 1:10.000. Os resultados permitiram identificar 5 Índices de Sensibilidade Ambiental ao derramamento de óleo. Com relação ao nível de sensibilidade das praias à erosão, verificou-se que Itupanema e Vila do Conde estão sobre forte influência erosiva e, Caripi possui parte de sua extensão submetida a este processo, sendo que o mesmo exerce influencia sobre as relações socioeconômicas do local. Para o nível de urbanização, as duas primeiras praias apresentam baixo percentual de ocupação, enquanto que Caripi apresenta maior extensão e demanda de uso e ocupação.
Teaching English for Elementary School Students through Communicative Language Teaching
Authors: Istiantika Intan , Jatuporn Jade , Setiawan Anjar
Published: July 2023

The aim of the implementation Communicative Language Teaching (CLT) in learning process is to change the teacher-centered learning process into student-centered learning, where students have the freedom to move and discuss all available materials. The method is given to students in grades three to six at SDN Jambangan during the Kampus Mengajar program. The CLT method is divided into four, namely the Communicative English teaching method, the practice question method, the question and Answer Session method, the guessing game method. Further, when learning is carried out, it was designed to make communicative activities such as games so that students don't feel bored. This learning process can provide opportunities for students to improve their language skills by using communicative English teaching methods. The findings showed that it is very helpful for educators to provide what is the right method to help students in dealing with existing problems and make learning fun. The students were active during the teaching and learning process. They did the teacher’s instruction cooperatively. Therefore, it can be concluded that learning can be carried out well and feels light when using the right stages. This research also helps the researcher to gain new experiences, which are very valuable experiences for life.
Collaborative Translanguaging Formative Assessment in Mother Tongue-Based Multilingual Education
Authors: Tejano Leonardo Daquioag
Published: July 2023

This research conducted classroom action research in Grade 1 of a Mother Tongue-Based Multilingual Education (MTB-MLE) program, which aims to promote the use of local languages as mediums of instruction in the early years of education. The study found that Ilokano learners tended to use English more often than Ilokano, which highlighted the importance of supporting their cultural identity and heritage through the MTB-MLE program. The Ilokano-Based Translanguaging Approach to Mother Tongue-Based Multilingual Education (IBTA-MTB-MLE) was developed to support instruction, and a formative assessment strategy called Collaborative Translanguaging Formative Assessment (CTFA) was developed to align with the teaching approach. The study aimed to test the effectiveness of CTFA by preparing four lesson sessions where learners work together to think, talk, write, and give feedback using their full range of linguistic repertoire. After the implementation of CTFA, a pre-test and post-test were conducted to determine the achievement of the Ilokano learners in MTB-MLE. The results showed that the majority of the students moved to higher ranges of score after the intervention, with an increase in mean scores from 20.1 to 25.87. The study highlights the benefits of translanguaging in language education and collaboration in assessment.
Regulation of the Implementation of Community Activity Restrictions in Combating Covid 19 in Bali
Authors: Mahadewi Kadek Julia
Published: July 2023

The purpose of this study is to apply the regulation of Community Activities in Bali Provision in the National Legal Order.The spread of Covid 19 has become an international and national threat.  The problem in this journal is How Effective the Regulation of Restrictions on Community Activities in Bali? and secondly the impact of the regulation of restrictions on community activities?. This writing method uses empirical research types, types of legal regulation approaches, case approaches, and approaches and uses primary and secondary data sources.  The increasing number of Covid 19 has made the Government make new regulations in its application to be able to suppress the rate of development.
Toward reaching hepatitis B goals: hepatitis B epidemiology and the impact of two decades of vaccination, Georgia, 2021
Authors: Khetsuriani Nino , Gamkrelidze Amiran , Shadaker Shaun , Tsereteli Maia , Alkhazashvili Maia , Chitadze Nazibrola , Tskhomelidze Irina , Gvinjilia Lia , Averhoff Francisco , Cloherty Gavin , An Qian , Chakhunashvili Giorgi , Drobeniuc Jan , Imnadze Paata , Zakhashvili Khatuna , Armstrong Paige A
Published: July 2023

Background

Georgia has adopted the World Health Organization European Region’s and global goals to eliminate viral hepatitis. A nationwide serosurvey among adults in 2015 showed 2.9% prevalence for hepatitis B virus (HBV) surface antigen (HBsAg) and 25.9% for antibodies against HBV core antigen (anti-HBc). HBV infection prevalence among children had previously not been assessed.

Aim

We aimed to assess HBV infection prevalence among children and update estimates for adults in Georgia.

Methods

This nationwide cross-sectional serosurvey conducted in 2021 among persons aged ≥ 5 years used multi-stage stratified cluster design. Participants aged 5–20 years were eligible for hepatitis B vaccination as infants. Blood samples were tested for anti-HBc and, if positive, for HBsAg. Weighted proportions and 95% confidence intervals (CI) were calculated for both markers.

Results

Among 5–17 year-olds (n = 1,473), 0.03% (95% CI: 0–0.19) were HBsAg-positive and 0.7% (95% CI: 0.3–1.6) were anti-HBc-positive. Among adults (n = 7,237), 2.7% (95% CI: 2.3–3.4) were HBsAg-positive and 21.7% (95% CI: 20.4–23.2) anti-HBc-positive; HBsAg prevalence was lowest (0.2%; 95% CI: 0.0–1.5) among 18–23-year-olds and highest (8.6%; 95% CI: 6.1–12.1) among 35–39-year-olds.

Conclusions

Hepatitis B vaccination in Georgia had remarkable impact. In 2021, HBsAg prevalence among children was well below the 0.5% hepatitis B control target of the European Region and met the ≤ 0.1% HBsAg seroprevalence target for elimination of mother-to-child transmission of HBV. Chronic HBV infection remains a problem among adults born before vaccine introduction. Screening, treatment and preventive interventions among adults, and sustained high immunisation coverage among children, can help eliminate hepatitis B in Georgia by 2030.
Características dos Discursos de Desinformação Relacionados aos Conhecimentos Científicos das Redes Bolsonaristas no Twitter
Authors: Pivaro Gabriela Fasolo , Girotto Júnior Gildo
Published: July 2023

Por mais que saibamos que discursos de ataque à credibilidade da ciência e a fabricação de notícias falsas não sejam um fenômeno recente, eles vêm ganhando maior visibilidade com a popularização das redes sociais. Devido aos algoritmos que regem o conteúdo mostrado ao usuário, criam-se bolhas ideológicas nas quais a desinformação encontra terreno fértil para se propagar. Pensando no contexto brasileiro, realizamos uma etnografia para a internet e analisamos as características dos discursos de desinformação relacionados aos conhecimentos científicos na rede social Twitter, entre usuários que participam de redes de apoio ao ex-presidente Jair Bolsonaro. Por meio da categorização do conteúdo reportados, discutimos não só sobre as características discursivas presentes nos tweets analisados, como também sobre como os processos de ensino aprendizagem em ciências e a falta de certos conhecimentos envolvendo o modo como conhecimentos científicos são construídos pode influenciar a propagação de desinformações. Apresentamos resultados que relacionam a experiência pessoal e imediata, os elos causais ocultos e o pertencimento identitário como características que influenciam a propagação das desinformações on-line. Comparamos estas características com lacunas em processos de ensino e aprendizagem em ciências. Concluímos destacando a importância tanto do entendimento de como funciona o filtro de conteúdo das redes sociais, como de uma educação que desenvolva modos de se pensar buscando por generalizações de conteúdos como formas de combate às desinformações.
Open Science and Humanism: Decolonization of Knowledge and Fractality of Identities
Authors: Mielkov Yurii
Published: July 2023

The paper is dedicated to philosophical analysis of the value foundations of the Open Science concept and its link to the more general concept of humanism, as the means for building up the common knowledge of humanity while still not sacrificing the diversity of existing cultures and traditions. The philosophical methods used in the investigation include dialectics and post-non-classical approach as it is argued that solving the problem of the coexistence of humans and human cultures and enabling the openness of human knowledge requires understanding the dialectical relation of unity and plurality. It is argued that openness as a major feature of contemporary scientific knowledge corresponds to both the classical principles of ethos of science – first of all, to universalism – and to the new trends in research and education that emerged thanks to the development of information technologies. Openness is shown to be a characteristic of a community that does not put its own private or corporate goals and values above the common human values – Open Science is thus closely linked with the idea of humanism. It is shown that at the same time such universalism is not opposed by, but rather presupposes decolonization of knowledge, as the alternative, local, traditional forms of knowledge augment universal knowledge of science based on rational inquiry rather than replace it. Human knowledge, as well as human culture and human identities in general, are argued to be fractal phenomena: diversity of alternative forms of knowledge, cultures, languages, world views etc. is in no way something that opposes the unity of humanity and vice versa, and that is a necessary way to achieve mutual respect, mutual recognition and mutual understanding of the humans.
The Language of the Weather Forecast in Italian and Spanish Television Broadcasts: Linguistic-Descriptive Analysis of the End of Winter on RTVE and TG5 Television Channels
Authors: Vallejo Rubén González
Published: July 2023

Weather information is of great importance to society due to the impact of the physical environment on everyday life. As a result, popular tradition has disseminated many proverbs related to human activities that have been the subject, over time, of scientific studies, intending to verify the veracity of such predictions. For this reason, this article initially presents a brief bibliographical and regulatory analysis of the evolution of atmospheric language and a presentation of the bodies that regulate its communication in Spain and Italy. Subsequently, a corpus of weather reports extracted during December 2022 from an Italian and Spanish news channel will be illustrated to study the communication of weather forecasts from a macro- and microstructural linguistic level, given the need for studies in both languages. For this purpose, Speechnotes will be used for the transcriptions, and Sketch Engine to create the corpus. As a result of the analysis, Spanish news programmes devote more time to the space of time, show a much higher speed of locution than the Italian corpus, provide a more significant number of mechanisms to show probability and uncertainty, and a great variety of linguistic-discursive strategies to exemplify the scientific context. We also find a recurrent gerund, which we will call an "atmospheric gerund". In Italian, on the other hand, we find greater deixis, more synthetic information, and less dynamism in the interaction with the data.
Funding
This work has been funded by the Margarita Salas grants for the training of young doctors (2021-2023) of the University of Salamanca
Applying Machine Learning to the Evaluation of Interviewer Performance
Authors: Sun Hanyu , Yan Ting
Published: July 2023

Survey organizations have long used Computer Assisted Recorded Interviewing (CARI) to monitor interviewer performance. Conventionally, a human coder needs to first listen to the audio recording of the interactions between the interviewer and the respondent and then evaluate and code features of the question-and-answer sequence using a pre-specified coding scheme. Although prior research found that providing feedback to interviewers based on CARI was effective at improving interviewer performance, such coding process tends to be labor intensive and time consuming. To improve the effectiveness and efficiency of using CARI to monitor interviewer performance, we developed a pipeline that heavily draws on the use of machine learning to process audio recorded interviews. In particular, machine learning is used to detect who spoke at which turn in a question-level audio recording and to transcribe conversations at the turn level. This paper describes how the pipeline was used to detect interviewer falsification and to identify problematic interviewer behavior in both recordings of mock interviews and actual field interviews. The performance of the pipeline was discussed.
PRINCÍPIOS E MOVIMENTOS PARA PROCESSOS PROJETUAIS REGENERATIVOS
Authors: Abreu Garcia Natalí , De Mello Freire Karine , Franzato Carlo
Published: July 2023

Frente à insustentabilidade dos modelos de desenvolvimento, torna-se urgente uma revisão profunda de nossas práticas, inclusive no âmbito do projeto. Para tanto, um caminho promissor é a adoção de uma perspectiva ecológica que possa nos fornecer chaves de leitura para operar nas diversas ecologias com as quais lidamos, ou seja, de acordo com Guattari, a do meio ambiente, a das relações sociais e a da subjetividade humana (ou mental). A partir disso, este artigo tem como objetivo a proposição de insumos metodológicos para a elaboração de processos projetuais orientados para uma sustentabilidade regenerativa, que têm como premissa a busca de realidades mais saudáveis, justas, singulares e solidárias, os quais possam contribuir para modos alternativos de projetar.
COBERTURAS VERDES: CONCEITO, APLICAÇÃO E DESEMPENHO
Authors: Okimoto Fernando S. , Mello Leonardo Ferreira de
Published: July 2023

O presente texto se trata de uma revisão bibliográfica dos conceitos, definições e desempenho das coberturas verdes, as quais são introduzidas com o intuito de promover benefícios econômicos e socioambientais no meio urbano. Tal tipo de cobertura permite  um melhor aproveitamento do espaço, permitindo um melhor conforto ambiental e eficiência energética, que gera como consequência  uma melhoria na qualidade de vida em sociedade.  Juntamente ,é apresentado nessa revisão bibliográfica  uma análise sobre a origem e a evolução dos telhados verdes ,  os tipos de vegetação adequados para  a sua constituição, a sua aplicação, desempenhos comparativos em diferentes climas, além das dificuldades e barreiras que se encontram para a sua construção. Verifica-se então, que as coberturas verdes são soluções funcionais para se tornar o meio urbano um ambiente mais atrativo , proveitoso e benéfico para os seus cidadãos.
DISCLOSURE DOS CUSTOS AMBIENTAIS: ANÁLISE TEMPORAL DAS EMPRESAS DE ENERGIA ELÉTRICA LISTADAS NO ÍNDICE DE SUSTENTABILIDADE EMPRESARIAL (ISE)
Authors: Binotti Francieli , Tomas Daiane Aline , Paeze Andrea , Bertolini Geysler
Published: July 2023

O estudo teve como objetivo identificar a evolução ocorrida no Disclosure dos custos ambientais das empresas do setor de energia elétrica listadas no ISE da B3. A pesquisa caracteriza-se como descritiva, com abordagem quantitativa dos dados, realizada por meio de pesquisa documental, aplicando análise de conteúdo. A amostra constitui-se de dados analisados nos relatórios de administração, sustentabilidade e balanço social das empresas que compõem o ISE de 2015 a 2019. Os resultados demonstram que houve um aumento de 6% no número de sentenças divulgadas do ano de 2019 em relação ao ano de 2015. Constatou-se a importância de existir um Disclosure ambiental padronizado, para melhor qualidade das informações evidenciadas. Conclui-se que algumas informações sobre custos ambientais que venham a favorecer a responsabilidade da companhia com o meio ambiente são mais evidenciadas, e que muitos desembolsos que a empresa faz para minimizar seus impactos ao meio ambiente, não são tratados como custos.
The remaining forces of Donghak and the trend of righteous army in Honam since 1894: Focusing on the 『Hongjae diary』 of Ki Haeng-hyun, a Buan Confucian scholar
Authors:   The Korean Society of History of Historiography, LEE Sun-Ah
Published: July 2023

『Hongjae Diary(1866-1911)』 is a diary written by Ki Haeng-hyeon(1843-?) who lived in Buan-gun, Jeolla-do. Ki haeng-hyeon recorded events, news, and rumors in Gobu, Taein, Namwon, and Jeonju, where the Donghak Peasant Revolution took place. He also recorded the trends of Yeonghakdang and Hwajeok, which were called the remaining forces of Donghak. The central government recognized it as a group like Donghak and the righteous army and suppressed the righteous army commander. In this way, Donghak-gun which was disbanded after the Donghak Peasant Revolution, continued its momentum as the remaining forces of Donghak, such as Yeonghakdang, Hwajeok, and Sujeok. Amid the continued suppression of the Donghak, the Iljinhoe was organized, and a person working as a Iljinhoe appeared in Buan. Iljinhoe intervened in local government authority and was also involved in the administration of village. This power of Iljinhoe was further strengthened when the Russo-Japanese War ended with Japan's victory and Japan-Korea Treaty of 1905 was signed. Since the signing of the Japan-Korea Treaty of 1905, righteous army has occurred in all parts of the country. The activities of the righteous army became stronger with the abdication of Gojong and the dissolution of the Korean army in 1907. Ki Haeng-hyeon recorded the size of the righteous army identified through newspapers, the murder or expulsion of local officials. After the Donghak Peasant Revolution, Donghak-gun in Honam returned to Yeonghakdang and continued its momentum as the remaining forces of Donghak including Hwajeok, and Sujeok. In an era when the sovereignty of the country was lost, Donghak's remaining forces were converted to righteous army by fighting against the Japanese army. Donghak-gun, suppressed by the Japanese military, rejoined the ranks of resistance against Japanese invasion as a righteous army.
The Embryology of the Lombardy Enlightenment: The Example of Pietro Verri
Authors:   The Korean Society of History of Historiography, Lim Donghyun
Published: July 2023

Under the rule of Maria Theresia, Lombardy was the centre of Italian Enlightenment. In the 1760s, members of the Academy of Fisticuffs led the social and economic reforms, keeping pace with the European Enlightenment. This study aims to reconstruct the political and social contexts of the Lombardy Enlightenment, focusing on the public and private life of Pietro Verri, an economist who led the movement as the founder of the Academy of Fisticuffs and the chief editor of Il Caffè, the most significant periodical of the time. This study examines Verri's duties as the eldest son, his differences with his father, his research on political economy, and his work in public service. At the time, all the members of the Academy of Fisticuffs were in a similar situation as Verri.
A Study on Standardization of Asset Accounting for Multi-regional Waterworks and Local Waterworks
Authors:   Korea Accounting Information Association, Lee Yong-Bae , Lee Yong-Seok , Chang Seok-Jin
Published: July 2023

[Purpose] The purpose of this study is to make policy proposals that can standardize the asset accounting treatment of the two facilities in order to alleviate problems that may arise due to the different laws and accounting standards of multi-regional waterworks and local waterworks. Although multi -regional and local waterworks are the same water supply facilities, the operators are divided into Korea Water Resources Corporation and local governments.
[Methodology] Analysis of related laws and accounting standards of Korea Water Resources Corporation and local governments, which operate the two facilities, and analysis of major issues and The latest cost data was analyzed.
[Findings] As a result of comparative analysis of asset management between the two facilities from the perspective of life cycle cost, it was confirmed that there were differences in the asset acquisition method, depreciation (useful life), treatment of borrowing cost, and accounting treatment of government subsidies. In order to standardize this difference, standardization alternatives were dashed in consideration of various viewpoints, such as the possibility of revision of related laws, the importance of the amount, the validity of the applied accounting standard, and the enhancement of competitiveness through systematic cost management.
[Implications] As the operating conditions of local waterworks deteriorate and the crisis of local extinction becomes a reality, various scenarios for waterworks integration are expected. Therefore, it is timely and meaningful to propose an alternative to standardization of accounting standards that can increase the comparability between the two facilities.
COVID-19 and Auditor Response
Authors:   Korea Accounting Information Association, Yun Yongsuk , Chu Jaeyon
Published: July 2023

[Purpose] The purpose of this study is to investigate auditors response to Coronavirus Disease(COVID-19). The outbreak of COVID-19 paralyses health, social, and economic parts and eventually it had considerable economic and financial impacts worldwide. To prevent the spread of the COVID-19, the government have urged people to stay at home. The COVID-19 led to negative impact on firms’ liquidity, profits and going-concern assumptions. Therefore, auditors might encounter some challenges during COVID-19 such as new audit procedures, a lack of verifying financial information and exceptional situation of manipulating accounting numbers. We investigate whether auditors input more audit hours during COVID-19.
[Methodology] This study uses 3,800 listed firm-years samples during prior year(2019) and the initial year of the COVID-19 outbreak(2020). We use audit hours of managers, registered certified public accountants, staff auditors, and all auditors for auditors response. To control industry effects during COVID-19, we apply fixed effects on our regression model.
[Findings] We find auditors input more working hours on year-end audits during COVID-19. It indicates that all types of auditors might put more efforts to mitigate audit risk. Also, we find that year-end audit hour ratio is increased during COVID- 19.
[Implications] As COVID-19 increases audit risk and also have auditors adopt a new audit procedures, COVID-19 could be a challenge to auditors. This study empirically shows how auditors respond to COVID-19. The auditors spend more audit hours during COVID-19 to mitigate audit risk and apply new procedures.
Studies of consciousness in Russian philosophical discorse: specificity, problems and prospects (on the example of the works of Russian and Belarusian authors)
Authors: Doronina S. G.
Published: July 2023

The author of the article considers and analyzes the main directions, problems and prospects of modern domestic philosophical studies of consciousness. A number of questions related to attempts to establish the main characteristics of the phenomenon of consciousness, to determine the key concepts and categories are raised. It is described to identify the structure of modern philosophical discourse. The main lines of development of interdisciplinary research of consciousness within the framework of such rapidly developing fields of knowledge as cognitive sciences, neurobiology, synergetic, etc. have been demonstrated. The paper establishes a general range of problems and issues related to the need for meaningful specification of concepts, substantiation of the arguments used in the study of this phenomenon. Poorly developed thematic blocks related to the issues of the origin of consciousness and its localization, the definition of its structural and content elements, the establishment of the mechanisms of its functioning, the practical implementation of the acquired knowledge are identified, which indicates the need for further attempts to study this object within the framework of philosophical discourse.
Understanding of the stories “The Mermaid” by Ales’ Kazhadub and “The Siren” by Giuseppe Tomasi di Lampeduza from the position of the theory of archetypes
Authors: Chesnokova E. V.
Published: July 2023

The article analyzes the stories “The Mermaid” by the Belarusian writer Ales’ Kazhadub and “The Siren” by the Italian writer Giuseppe Tomasi di Lampedusa for the purpose of revealing in them the character of the archetypal basis, distinctive genre-thematic and artistic-visual features. A comprehensive approach to the analysis of the literary works was provided by such methods as mythopoetic, hermeneutic, cultural-historical and comparative. The writers embodied the archetype of the Great Mother in the images of chthonic creatures (a siren and a mermaid). A consistent analysis of the images and plots of the stories made it possible to define a circle of universal images that made up the “archetypal core” of the given works (the Hero/the Child/the Warrior, the Shadow, the Leader/the Wise, the Lover (or one who is capable of love), the Journey, etc.), and also to clarify the features of their genres, to trace the influence of artistic methods on the character of the characters and certain development of the plot lines.
Features of organization of labour of Belarusian workers
Authors: Makovskaya N. V.
Published: July 2023

The article presents the results of a study of the peculiarities of the organization of labor of Belarusian workers, which has already undergone changes in the context of digital transformation and innovative development of the economy, and requires some improvement in the Republic of Belarus. The organization of labor is presented from the standpoint of the methodology of labor economics and methods of sociological analysis. New methodological approaches to monitoring the organization of labor based on sociological methods and economic and mathematical tools are presented. The factors influencing the state of labor organization and working conditions in the workplace are discussed. Analysis and assessments were obtained using an expert database of opinions of Belarusian workers. The results of the assessments showed that there are a number of national peculiarities in the organization of labor, which are associated with the reasons for changing jobs, with working conditions and wages at the workplace, with the availability of additional income for workers, with the level of job satisfaction. It is proved that: in Belarusian organizations, the authority of the leader is high, and he determines the desire of employees to perform an additional amount of workload; work with better working conditions and a smaller workload is a significant priority when choosing the trajectories of the labor movement of workers in Belarusian organizations.