bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlation between Volumes Determined by Echocardiography and Cardiac MRI in Controls and Atrial Fibrillation Patients
Authors: Manole Simona , Budurea Claudia , Pop Sorin , Iliescu Alin M. , Ciortea Cristiana A. , Iancu Stefania D. , Popa Loredana , Coman Mihaela , Szabó László , Coman Vasile , Bálint Zoltán
Published: December 2021

Aims: We aimed to compare cardiac volumes measured with echocardiography (echo) and cardiac magnetic resonance imaging (MRI) in a mixed cohort of healthy controls (controls) and patients with atrial fibrillation (AF). Materials and methods: In total, 123 subjects were included in our study; 99 full datasets were analyzed. All the participants underwent clinical evaluation, EKG, echo, and cardiac MRI acquisition. Participants with full clinical data were grouped into 63 AF patients and 36 controls for calculation of left atrial volume (LA Vol) and 51 AF patients and 30 controls for calculation of left ventricular end-diastolic volume (LV EDV), end-systolic volume (ESV), and LV ejection fraction (LV EF). Results: No significant differences in LA Vol were observed (p > 0.05) when measured by either echo or MRI. However, echo provided significantly lower values for left ventricular volume (p < 0.0001). The echo LA Vol of all the subjects correlated well with that measured by MRI (Spearmen correlation coefficient r = 0.83, p < 0.0001). When comparing the two methods, significant positive correlations of EDV (all subjects: r = 0.55; Controls: r = 0.71; and AF patients: r = 0.51) and ESV (all subjects: r = 0.62; Controls: r = 0.47; and AF patients: r = 0.66) were found, with a negative bias for values determined using echo. For a subgroup of participants with ventricular volumes smaller than 49.50 mL, this bias was missing, thus in this case echocardiography could be used as an alternative for MRI. Conclusion: Good correlation and reduced bias were observed for LA Vol and EF determined by echo as compared to cardiac MRI in a mixed cohort of patients with AF and healthy volunteers. For the determination of volume values below 49.50 mL, an excellent correlation was observed between values obtained using echo and MRI, with comparatively reduced bias for the volumes determined by echo. Therefore, in certain cases, echocardiography could be used as a less expensive, less time-consuming, and contraindication free alternative to MRI for cardiac volume determination.
The Sixth Edition of the WHO Manual for Human Semen Analysis: A Critical Review and SWOT Analysis
Authors: Boitrelle Florence , Shah Rupin , Saleh Ramadan , Henkel Ralf , Kandil Hussein , Chung Eric , Vogiatzi Paraskevi , Zini Armand , Arafa Mohamed , Agarwal Ashok
Published: December 2021

Semen analysis is the cornerstone of male fertility evaluation with WHO guidelines providing the basis for procedural standardization and reference values worldwide. The first WHO manual was published in 1980, and five editions have been subsequently released over the last four decades. The 6th Edition was published in July 2021. In this review, we identify the key changes of this 6th Edition. Additionally, we evaluate the utility of this 6th Edition in clinical practice using SWOT (strengths, weaknesses, opportunities, and threats) analysis. This new Edition has made the analysis of basic semen parameters more robust, taking into account the criticisms and grey areas of the previous editions. The tests assessing sperm DNA fragmentation and seminal oxidative stress are well-described. The main novelty is that this latest edition abandons the notion of reference thresholds, suggesting instead to replace them with “decision limits”. While this seems attractive, no decision limits are proposed for either basic semen parameters, or for extended or advanced parameters. This critical review of the 6th Edition of the WHO laboratory manual combined with a SWOT analysis summarizes the changes and novelties present in this new Edition and provides an in-depth analysis that could help its global use in the coming years.
Role of Biomarkers in the Diagnosis and Treatment of Inflammatory Bowel Disease
Authors: Wagatsuma Kohei , Yokoyama Yoshihiro , Nakase Hiroshi
Published: December 2021

The number of patients with inflammatory bowel disease (IBD) is increasing worldwide. Endoscopy is the gold standard to assess the condition of IBD. The problem with this procedure is that the burden and cost on the patient are high. Therefore, the identification of a reliable biomarker to replace endoscopy is desired. Biomarkers are used in various situations such as diagnosis of IBD, evaluation of disease activity, prediction of therapeutic effect, and prediction of relapse. C-reactive protein and fecal calprotectin have a lot of evidence as objective biomarkers of disease activity in IBD. The usefulness of the fecal immunochemical test, serum leucine-rich glycoprotein, and urinary prostaglandin E major metabolite have also been reported. Herein, we comprehensively review the usefulness and limitations of biomarkers that can be used in daily clinical practice regarding IBD. To date, no biomarker is sufficiently accurate to replace endoscopy; however, it is important to understand the characteristics of each biomarker and use the appropriate biomarker at the right time in daily clinical practice.
SARS-CoV-2 and Implantation Window: Gene Expression Mapping of Human Endometrium and Preimplantation Embryo
Authors: Haouzi Delphine , Entezami Frida , Tuaillon Edward , Gala Anna , Ferrières-Hoa Alice , Brouillet Sophie , Thierry Alain R. , Hamamah Samir
Published: December 2021

Understanding whether SARS-CoV-2 could infect cells and tissues handled during ART is crucial for risk mitigation, especially during the implantation window when either endometrial biopsies are often practiced for endometrial receptivity assessment or embryo transfer is performed. To address this question, this review analyzed current knowledge of the field and retrospectively examined the gene expression profiles of SARS-CoV-2-associated receptors and proteases in a cohort of ART candidates using our previous Affymetrix microarray data. Human endometrial tissue under natural and controlled ovarian stimulation cycles and preimplantation embryos were analyzed. A focus was particularly drawn on the renin-angiotensin system, which plays a prominent role in the virus infection, and we compared the gene expression levels of receptors and proteases related to SARS-CoV-2 infection in the samples. High prevalence of genes related to the ACE2 pathway during both cycle phases and mainly during the mid-secretory phase for ACE2 were reported. The impact of COS protocols on endometrial gene expression profile of SARS-CoV-2-associated receptors and proteases is minimal, suggesting no additional potential risks during stimulated ART procedure. In blastocysts, ACE2, BSG, CTSL, CTSA and FURIN were detectable in the entire cohort at high expression level. Specimens from female genital tract should be considered as potential targets for SARS-CoV-2, especially during the implantation window.
Logistics Work, Ergonomics and Social Sustainability: Empirical Musculoskeletal System Strain Assessment in Retail Intralogistics
Authors: Loske Dominic , Klumpp Matthias , Keil Maria , Neukirchen Thomas
Published: December 2021

Background: A large proportion of logistics jobs still rely on manual labor and therefore place a physical strain on employees. This includes the handling of heavy goods and physiologically unfavorable postures. Such issues pose a risk for employee health and work capability. This article provides a detailed empirical analysis and a decision process structure for the allocation of ergonomic measures in warehousing and intralogistics processes. Methods: The methodological basis is a load assessment of the musculoskeletal system in retail intralogistics. Based on the established measurements systems CUELA and OWAS, the specific loads on employees are assessed for four typical logistics workplace settings. These are combined with standards for efficient decision rules regarding contracting and developing ergonomic improvements. Results: The results suggest an increased risk of long-term low back injury for the selected four standard work situations in warehousing and likely apply to similar work environments in logistics. Using measures, posture descriptions, and international standards, we show how already few threshold values serve as sufficient conditions to decide if ergonomic interventions are required. Conclusions: The specific contribution is characterized by the combination of literature review results, empirical results, and the identification and discussion of specific mitigation measures. These elements are focused on the highly relevant ergonomic situation of logistics workers and present a unique contribution towards the knowledge base in this field due to the multi-perspective approach.
Fundamentals and Advances in Elastohydrodynamics: The Role of Ramsey Gohar
Authors: Johns-Rahnejat Patricia M. , Karami Ghodrat , Aini Reza , Rahnejat Homer
Published: December 2021

This paper commemorates Ramsey Gohar by acknowledging his contributions to the fields of contact mechanics and elastohydrodynamic lubrication (EHL) within the context of the developments of these subjects. A historical discourse is provided on elastohydrodynamics, from its inception in the 1940s to present. We demonstrate that Ramsey Gohar was not only a pioneer in the discoveries and fundamentals of the subject, but also led or contributed significantly to continual advances in the understanding of EHL and its diverse applications.
The Characteristic of Fe as a β-Ti Stabilizer in Ti Alloys
Authors: Min Jin , Guo Yanhua , Niu Jingzhe , Cao Juexian , Sun Zhonggang , Chang Hui
Published: December 2021

It is well known that adding elements, especially β-Ti stabilizers, are holding a significant effect on titanium alloy strength due to the solution and precipitate strengthening mechanisms. In order to reveal the Fe strengthening mechanism in titanium, this study investigate the effect of Fe on the stability of β-Ti and the phase transition between α, β and ω phase with first-principle calculations. According to our study, Fe is a strong β-Ti phase stabilizer could owe to the 3d orbital into eg and t2g states which results in strong hybridization between Fe-d orbital and Ti-d orbital. The phase transition from ω to β or from α to β becomes easier for Fe-doped Ti compared to pure titanium. Based on our results, it is found that one added Fe atom can lead the phase transition (ω → β) of at least nine titanium atoms, which further proves that Fe has a strong stabilizing effect on β-Ti phase. This result provides a solid guide for the future design of high-strength titanium with the addition of Fe.
Synthesis of Sb2S3 NRs@rGO Composite as High-Performance Anode Material for Sodium-Ion Batteries
Authors: Hwang Hosung , Seong Honggyu , Lee So Yi , Moon Joon Ha , Kim Sung Kuk , Lee Jin Bae , Myung Yoon , Na Chan Woong , Choi Jaewon
Published: December 2021

Sodium ion batteries (SIBs) have drawn interest as a lithium ion battery (LIB) alternative owing to their low price and low deposits. To commercialize SIBs similar to how LIBs already have been, it is necessary to develop improved anode materials that have high stability and capacity to operate over many and long cycles. This paper reports the development of homogeneous Sb2S3 nanorods (Sb2S3 NRs) on reduced graphene oxide (Sb2S3 NRs @rGO) as anode materials for SIBs. Based on this work, Sb2S3 NRs show a discharge capacity of 564.42 mAh/g at 100 mA/g current density after 100 cycles. In developing a composite with reduced graphene oxide, Sb2S3 NRs@rGO present better cycling performance with a discharge capacity of 769.05 mAh/g at the same condition. This achievement justifies the importance of developing Sb2S3 NRs and Sb2S3 NRs@rGO for SIBs.
Laser Processing of Diffusion Boronized Layer Produced on Monel® Alloy 400—Microstructure, Microhardness, Corrosion and Wear Resistance Tests
Authors: Bartkowska Aneta , Bartkowski Dariusz , Przestacki Damian , Kukliński Mateusz , Miklaszewski Andrzej , Kieruj Piotr
Published: December 2021

The paper presents the results of studies of microstructure, mechanical and physicochemical properties of surface layers produced by laser modification of the diffusion boron layer on Monel® Alloy 400. The diffusion boron layers were produced at 950 °C for 6 h. The gas-contact method was used in an open retort furnace. The process was carried out in a powder mixture containing B4C carbide as a boron source. The next stage was the modification of the boron layer with a diode laser beam of a nominal power of 3 kW. A constant power of 1400 W of the laser beam was used. The scanning speed was variable (successively 5 m/min, 25 m/min, 50 m/min). In order to determine the best parameters, single tracks were created, after which multiple tracks were prepared using previously selected parameters. It was found that both the diffusion borided layer and the laser modified layer had better properties than the substrate material. Both these processes contributed to an increase in corrosion resistance, hardness and wear resistance. It was also found that laser modification caused a slight deterioration of the properties in comparison with the diffusion borided layer. However, the laser modification process resulted in the production of a much thicker layer.
The Soft and High Actuation Response of Graphene Oxide/Gelatin Soft Gel
Authors: Chungyampin Supanit , Niamlang Sumonman
Published: December 2021

The high actuation response of soft gel from a graphene oxide/gelatin composite was prepared as an alternative material in soft robotics applications. Graphene oxide (GO) was selected as the electroresponsive (ER) particle. GO was synthesized by modifying Hummer’s method at various ratios of graphite (GP) to potassium permanganate (KMnO4). To study the effect of ER particles on electromechanical properties, GO was blended with gelatin hydrogel (GEL) at various concentrations. The electrical properties of the ER particles (GO and GP) and matrix (GEL) were measured. The capacitance (C), resistance (R), and dielectric constant of the GO/GEL composite were lower than those of the GO particles but higher than those of the GEL and GP/GEL composite at the given number of particles. The effects of external electric field strength and the distance between electrodes on the degree of bending and the dielectrophoresis force (Fd) were investigated. When the external electric field was applied, the composite bent toward electrode, because the electric field polarized the functional group of polymer molecules. Under applied 400 V/mm, the GO/GEL composite (5% w/w) showed the highest deflection angle (θ = 82.88°) and dielectrophoresis force (7.36 N). From the results, we conclude that the GO/GEL composite can be an alternative candidate material for electromechanical actuator applications.
Synthesis Method and Thermodynamic Characteristics of Anode Material Li3FeN2 for Application in Lithium-Ion Batteries
Authors: Popovich Anatoliy , Novikov Pavel , Wang Qingsheng , Pushnitsa Konstantin , Aleksandrov Daniil
Published: December 2021

Li3FeN2 material was synthesized by the two-step solid-state method from Li3N (adiabatic camera) and FeN2 (tube furnace) powders. Phase investigation of Li3N, FeN2, and Li3FeN2 was carried out. The discharge capacity of Li3FeN2 is 343 mAh g−1, which is about 44.7% of the theoretic capacity. The ternary nitride Li3FeN2 molar heat capacity is calculated using the formula Cp,m = 77.831 + 0.130 × T − 6289 × T−2, (T is absolute temperature, temperature range is 298–900 K, pressure is constant). The thermodynamic characteristics of Li3FeN2 have the following values: entropy S0298 = 116.2 J mol−1 K−1, molar enthalpy of dissolution ΔdHLFN = −206.537 ± 2.8 kJ mol−1, the standard enthalpy of formation ΔfH0 = −291.331 ± 5.7 kJ mol−1, entropy S0298 = 113.2 J mol−1 K−1 (Neumann–Kopp rule) and 116.2 J mol−1 K−1 (W. Herz rule), the standard Gibbs free energy of formation ΔfG0298 = −276.7 kJ mol−1.
Pin Angle Thermal Effects on Friction Stir Welding of AA5058 Aluminum Alloy: CFD Simulation and Experimental Validation
Authors: Chupradit Supat , Bokov Dmitry Olegovich , Suksatan Wanich , Landowski Michał , Fydrych Dariusz , Abdullah Mahmoud E. , Derazkola Hesamoddin Aghajani
Published: December 2021

The friction stir welding (FSW) of tool pin geometry plays a critical role in the final properties of the produced joint. The tool pin geometry directly affects the generation of heat and the flow of internal materials during the FSW process. The effects of the FSW tool pin angle on heat generation and internal flow have not been quantitatively investigated in detail. In this manuscript, a validated Computational Fluid Dynamic (CFD) model was implemented to analyze the effects of pin angle on the thermo-mechanical action during the FSW process of AA5058 Al-Mg alloy. Experimental test results validate the thermal outcomes of the used model. The obtained results revealed that, when the pin angle is increased, the heat generation decreases while the mechanical action of the tool increases. The internal heat distribution at a higher pin angle is symmetrical. The higher mechanical action of the tool decreases the viscosity of the internal materials and increases stirring action (materials flow) around the pin. Furthermore, plastic flow near the tool increased stirring action and formed a larger stir zone in the joint area.
Experimental Study on Coupling Influence of Temperature and Confining Pressure to Deformation and Strength Characteristics of Rock-like Material with Pre-Existing Crack
Authors: Wang Hongwei , Wang Yongyan , Fu Xi
Published: December 2021

In this paper, destructive compression tests under the coupled influence of temperatures (20–60 °C) and confining pressures (0–7 MPa) were carried out on rock-like material with pre-existing crack to explore the deformation and strength characteristics. The stress–strain curves of rock-like material under the coupled influence of temperatures and confining pressures were obtained. Meanwhile, the correlations of peak stress, peak strain, and average Young’s modulus with temperatures and confining pressures were obtained. The results of the experiments indicate that, firstly, the compressive strength decreased and the deformation increased due to the influence of pre-existing cracks; the combined effect of initial cracks, temperature, and confining pressure gave rise to a more complicated mechanism of soft rock deformation. Secondly, the deformation of rock-like material was affected by initial cracks, confining pressures, and temperatures, but the influence of temperature was lower than that of confining pressure and initial crack. The failure mode of rock-like material was brittle at the confining pressure of 0 and 1 MPa and plastic at the confining pressure of 5 and 7 MPa. The critical confining pressure value of failure mode for rock-like material was 3 MPa. Thirdly, the peak strength and peak strain of rock-like material increased with confining pressure. Temperature had less influence on the rock-like material strength and peak strain than confining pressure. Lastly, Young’s modulus decreased with temperature and confining pressure.
In Situ Monitoring of Pulsed Laser Annealing of Eu-Doped Oxide Thin Films
Authors: Novotný Michal , Remsa Jan , Havlová Šárka , More-Chevalier Joris , Irimiciuc Stefan Andrei , Chertopalov Sergii , Písařík Petr , Volfová Lenka , Fitl Přemysl , Kmječ Tomáš , Vrňata Martin , Lančok Ján
Published: December 2021

Eu3+-doped oxide thin films possess a great potential for several emerging applications in optics, optoelectronics, and sensors. The applications demand maximizing Eu3+ photoluminescence response. Eu-doped ZnO, TiO2, and Lu2O3 thin films were deposited by Pulsed Laser Deposition (PLD). Pulsed UV Laser Annealing (PLA) was utilized to modify the properties of the films. In situ monitoring of the evolution of optical properties (photoluminescence and transmittance) at PLA was realized to optimize efficiently PLA conditions. The changes in optical properties were related to structural, microstructural, and surface properties characterized by X-ray diffraction (XRD) and atomic force microscopy (AFM). The substantial increase of Eu3+ emission was observed for all annealed materials. PLA induces crystallization of TiO2 and Lu2O3 amorphous matrix, while in the case of already nanocrystalline ZnO, rather surface smoothening0related grains’ coalescence was observed.
Combining Micro-Raman Spectroscopy and Scanning Electron Microscopy Mapping: A Stony Meteorite Study
Authors: Musa Maya , Rossini Riccardo , Di Martino Daniela , Riccardi Maria Pia , Clemenza Massimiliano , Gorini Giuseppe
Published: December 2021

Meteorite characterisation represents a privileged and unique opportunity to increase our knowledge about the materials composing the Universe and, particularly, the Proto Solar System. Moreover, meteorites studies evolve contextually with the development of analytical technologies. In the present paper, the results from an unclassified stony meteorite (chondrite) characterisation have been reported on the basis of the innovative analytical protocol presented here. Advanced Mapping by micro-Raman Spectroscopy and Scanning Electron Microscopy equipped with Energy Dispersive Spectroscopy have been combined to disclose molecular and elemental features on the same regions sample at a micrometric resolution. Thanks to their non-destructive properties, the mapping tools of both instruments have been applied to single chondrules analysis and the best match between the mineralogical information and the chemical composition has been obtained. This combined approach proved to be highly suitable in disclosing the crystallinity features of the phases, with in-depth spatial and morphological details too.
Experimental and Numerical Investigations on High Performance SFRC: Cyclic Tensile Loading and Fatigue
Authors: Schäfer Niklas , Gudžulić Vladislav , Breitenbücher Rolf , Meschke Günther
Published: December 2021

In the present study, the capability of high-strength short steel fibers to control the degradation in high-performance concrete was experimentally examined and numerically simulated. To this end, notched prismatic high-performance concrete specimens with (HPSFRC) and without (HPC) short steel fibers were subjected to static and cyclic tensile tests up to 100,000 cycles. The cyclic tests showed that the rate of strain increase was lower for HPSFRC specimens and that the strain stagnated after around 10,000 cycles, which was not the case with HPC specimens. The microscopic examinations showed that in HPSFRC, a larger number of microcracks developed, but they had a smaller total surface area than the microcracks in the HPC. To further investigate the influence of fibers on the behavior of HPSFRC in the cracked state, displacement-controlled crack opening tests, as well as numerical simulations thereof, were carried out. Experiments have shown, and the numerical simulations have confirmed, that the inclusion of short steel fibers did not significantly affect the ultimate strength; however, it notably increased the post-cracking ductility of the material. Finally, the unloading/reloading behavior was examined, and it was observed that the unloading stiffness was stable even for significant crack openings; however, the hysteresis loops due to unloading/reloading were very small.
Experimental Investigation on Geopolymer Concrete with Various Sustainable Mineral Ashes
Authors: Subash Narayanan , Avudaiappan Siva , Adish Kumar Somanathan , Amran Mugahed , Vatin Nikolai , Fediuk Roman , Aepuru Radhamanohar
Published: December 2021

The aim of this research was to find the best alternative for river sand in concrete. In both geopolymer concrete (GPC) and cement concrete (CC), the fine aggregates are replaced with various sustainable mineral ashes, and mechanical and durability tests are conducted. Specimens for tests were made of M40 grade GPC and CC, with five different soil types as river sand substitute. The materials chosen to replace the river sand are manufactured sand (M-sand), sea sand, copper slag, quarry dust, and limestone sand as 25%, 50%, 75%, and 100%, respectively by weight. GPF50 and CC50 were kept as control mixes for GPC and CC, respectively. The test results of respective concretes are compared with the control mix results. From compressive strength results, M-sand as a fine aggregate had an increase in strength in every replacement level of GPC and CC. Additionally, copper slag is identified with a significant strength reduction in GPC and CC after 25% replacement. Copper slag, quarry dust, and limestone sand in GPC and CC resulted in considerable loss of strength in all replacement levels except for 25% replacement. The cost of GPC and CC is mixed with the selected fine aggregate replacement materials which arrived. Durability and cost analyses are performed for the advisable mixes and control mixes to have a comparison. Durability tests, namely, water absorption and acid tests and water permeability and thermal tests are conducted and discussed. Durability results also indicate a positive signal to mixes with M-sand. The advisable replacement of river sand with each alternative is discussed.
Crack-Bridging Property Evaluation of Synthetic Polymerized Rubber Gel (SPRG) through Yield Stress Parameter Identification
Authors: Lee Jong-Yong , Seo Hyun-Jae , Oh Kyu-Hwan , Bo Jiang , Oh Sang-Keun
Published: December 2021

Yield stress parameter derivation was conducted by stress-strain curve analysis on four types of grout injection leakage repair materials (GILRM); acrylic, epoxy, urethane and SPRG grouts. Comparative stress-strain curve analysis results showed that while the yield stress point was clearly distinguishable, the strain ratio of SPRG reached up to 664% (13 mm) before material cohesive failure. A secondary experimental result comprised of three different common component ratios of SPRG was conducted to derive and propose an averaged yield stress curve graph, and the results of the yield stress point (180% strain ratio) were set as the basis for repeated stress-strain curve analysis of SPRGs of up to 15 mm displacement conditions. Results showed that SPRG yield stress point remained constant despite repeated cohesive failure, and the modulus of toughness was calculated to be on average 53.1, 180.7, and 271.4 N/mm2, respectively, for the SPRG types. The experimental results of this study demonstrated that it is possible to determine the property limits of conventional GILRM (acrylic, epoxy and urethane grout injection materials) based on yield stress. The study concludes with a proposal on potential application of GILRM toughness by finite element analysis method whereby strain of the material can be derived by hydrostatic pressure. Comparative analysis showed that the toughness of SPRG materials tested in this study are all able to withstand hydrostatic pressure range common to underground structures (0.2 N/mm2). It is expected that the evaluation method and model proposed in this study will be beneficial in assessing other GILRM materials based on their toughness values.
Eco Friendly Synthesis of Carbon Dot by Hydrothermal Method for Metal Ions Salt Identification
Authors: Shabbir Hasan , Tokarski Tomasz , Ungor Ditta , Wojnicki Marek
Published: December 2021

In this work, we report the synthesis method of carbon quantum dots (CDs) using the one-step method for fast and effective metal ion determination. Ascorbic acid was used as an inexpensive and environmentally friendly precursor. High-pressure and high-temperature reactors were used for this purpose. Microscopic characterization revealed the size of CDs was in the range of 2–6 nm and they had an ordered structure. The photoluminescence properties of the CDs depend on the process temperature, and we obtained the highest PL spectra for 6 h of hydrothermal reaction. The maximum emission spectra depend poorly on synthesis time. Further characterization shows that CDs are a good contender for sensing Fe3+ in aqueous systems and can detect concentrations up to 0.49 ppm. The emission spectra efficiency was enhanced by up to 200% with synthesis time.
Analysis of Explainers of Black Box Deep Neural Networks for Computer Vision: A Survey
Authors: Buhrmester Vanessa , Münch David , Arens Michael
Published: December 2021

Deep Learning is a state-of-the-art technique to make inference on extensive or complex data. As a black box model due to their multilayer nonlinear structure, Deep Neural Networks are often criticized as being non-transparent and their predictions not traceable by humans. Furthermore, the models learn from artificially generated datasets, which often do not reflect reality. By basing decision-making algorithms on Deep Neural Networks, prejudice and unfairness may be promoted unknowingly due to a lack of transparency. Hence, several so-called explanators, or explainers, have been developed. Explainers try to give insight into the inner structure of machine learning black boxes by analyzing the connection between the input and output. In this survey, we present the mechanisms and properties of explaining systems for Deep Neural Networks for Computer Vision tasks. We give a comprehensive overview about the taxonomy of related studies and compare several survey papers that deal with explainability in general. We work out the drawbacks and gaps and summarize further research ideas.
A Mathematical Model of the Production Inventory Problem for Mixing Liquid Considering Preservation Facility
Authors: Rahman Md Sadikur , Das Subhajit , Manna Amalesh Kumar , Shaikh Ali Akbar , Bhunia Asoke Kumar , Cárdenas-Barrón Leopoldo Eduardo , Treviño-Garza Gerardo , Céspedes-Mota Armando
Published: December 2021

The mixing process of liquid products is a crucial activity in the industry of essential commodities like, medicine, pesticide, detergent, and so on. So, the mathematical study of the mixing problem is very much important to formulate a production inventory model of such type of items. In this work, the concept of the mixing problem is studied in the branch of production inventory. Here, a production model of mixed liquids with price-dependent demand and a stock-dependent production rate is formulated under preservation technology. In the formulation, first of all, the mixing process is presented mathematically with the help of simultaneous differential equations. Then, the mixed liquid produced in the mixing process is taken as a raw material of a manufacturing system. Then, all the cost components and average profit of the system are calculated. Now, the objective is to maximize the corresponding profit maximization problem along with the highly nonlinear objective function. Because of this, the mentioned maximization problem is solved numerically using MATHEMATICA software. In order to justify the validity of the model, two numerical examples are worked out. Finally, to show the impact of inventory parameters on the optimal policy, sensitivity analyses are performed and the obtained results are presented graphically.
Soluble Polysaccharide Derived from Laminaria japonica Attenuates Obesity-Related Nonalcoholic Fatty Liver Disease Associated with Gut Microbiota Regulation
Authors: Zhang Yiping , Yang Longhe , Zhao Nannan , Hong Zhuan , Cai Bing , Le Qingqing , Yang Ting , Shi Lijun , He Jianlin
Published: December 2021

In this study, the effects of a polysaccharide derived from Laminaria japonica (LJP) on obesity were investigated in mice fed a high-fat diet (HFD). LJP significantly attenuated obesity-related features, lowering serum triglycerides, glucose, total cholesterol and low-density lipoprotein cholesterol levels. HFD-induced liver steatosis and hepatocellular ballooning were significantly attenuated by LJP. Additionally, LJP was found to significantly modulate hepatic gene expressions of AMPK and HMGCR, which are key regulators of lipid and cholesterol metabolism. We further found that LJP ameliorated HFD-induced gut microbiota (GM) dysbiosis by significantly reducing the obesity-related Firmicutes to Bacteroidetes ratio, meanwhile promoting the growth of Verrucomicrobia at the phylum level. At the genus level, propionate-producing bacteria Bacteroides and Akkermansia were elevated by LJP, which might explain the result that LJP elevated fecal propionate concentration. Taken together, these findings suggest that dietary intake of LJP modulates hepatic energy homeostasis to alleviate obesity-related nonalcoholic fatty liver disease associated with GM regulation.
Oral Bioavailability of Omega-3 Fatty Acids and Carotenoids from the Microalgae Phaeodactylum tricornutum in Healthy Young Adults
Authors: Stiefvatter Lena , Lehnert Katja , Frick Konstantin , Montoya-Arroyo Alexander , Frank Jan , Vetter Walter , Schmid-Staiger Ulrike , Bischoff Stephan C.
Published: December 2021

The microalgae Phaeodactylum tricornutum (PT) contains valuable nutrients such as proteins, polyunsaturated omega-3 fatty acids (n-3 PUFA), particularly eicosapentaenoic acid (EPA) and some docosahexaenoic acid (DHA), carotenoids such as fucoxanthin (FX), and beta-glucans, which may confer health benefits. In a randomized intervention trial involving 22 healthy individuals, we administered for two weeks in a crossover manner the whole biomass of PT (5.3 g/day), or fish oil (FO) containing equal amounts of EPA and DHA (together 300 mg/day). In an additional experiment, sea fish at 185 g/week resulting in a similar EPA and DHA intake was administered in nine individuals. We determined the bioavailability of fatty acids and carotenoids and assessed safety parameters. The intake of PT resulted in a similar increase in the n-3 PUFA and EPA content and a decrease in the PUFA n-6:n-3 ratio in plasma. PT intake caused an uptake of FX that is metabolized to fucoxanthinol (FXOH) and amarouciaxanthin A (AxA). No relevant adverse effects occurred following PT consumption. The study shows that PT is a safe and effective source of EPA and FX—and likely other nutrients—and therefore should be considered as a future sustainable food item.
A Pattern of Care Report on the Management of Patients with Squamous Cell Carcinoma of the Anus—A Study by the Italian Association of Radiotherapy and Clinical Oncology (AIRO) Gastrointestinal Tumors Study Group
Authors: Franco Pierfrancesco , Chiloiro Giuditta , Montesi Giampaolo , Montrone Sabrina , Arcelli Alessandra , Comito Tiziana , Arcadipane Francesca , Caravatta Luciana , Macchia Gabriella , Lupattelli Marco , Niespolo Marina Rita , Munoz Fernando , Palazzari Elisa , Krengli Marco , Valvo Francesca , Gambacorta Maria Antonietta , Genovesi Domenico , Mantello Giovanna
Published: December 2021

Background and objectives: The diagnosis and therapy of squamous cell carcinoma of the anus may vary significantly in daily clinical practice, even if international guidelines are available. Materials and Methods: We conducted a pattern of care survey to assess the management of patients with anal cancer in Italy (38 questions). We analyzed 58 questionnaires. Results: Most of the respondents work in public and/or university hospitals (75.8%) in northern Italy (65.5%). The majority (88.0%) treat less than 20 patients/year. Common examinations for diagnosis and staging are anorectal endoscopy (84.5%), computed tomography scan (86.2%) and pelvic magnetic resonance imaging (MRI) (96.5%). The most frequently prescribed dose to primary tumor is 50–54 Gy (46.5–58.6%) for early stage disease and 54–59.4 Gy (62.1–32.8%) for locally advanced cases. Elective volumes are prescribed around 45 Gy (94.8%). Most participants use volumetric intensity modulated radiotherapy (89.7%) and a simultaneous integrated boost (84.5%). Concurrent radiotherapy, 5-fluorouracil and mitomycin is considered the standard of care (70.6%). Capecitabine is less frequently used (34.4%). Induction chemotherapy is an option for extensive localized disease (65.5%). Consolidation chemotherapy is rarely used (18.9%). A response evaluation is conducted at 26–30 weeks (63.9%) with a pelvic MRI (91.4%). Follow-up is generally run by the multidisciplinary tumor board (62.1%). Conclusions: Differences were observed for radiotherapy dose prescription, calling for a consensus to harmonize treatment strategies.
Melting and Re-Freezing Leads to Irreversible Changes in the Morphology and Molecular-Level Dynamics of Pfizer-BioNTech COVID-19 Vaccine
Authors: Mamontov Eugene , Daemen Luke L. , Novak Eric , Stone Matthew B.
Published: December 2021

Background and Objectives: As an mRNA-based vaccine, the Pfizer-BioNTech COVID-19 vaccine has stringent cold storage requirements to preserve functionality of the mRNA active ingredient. To this end, lipid components of the vaccine formulation play an important role in stabilizing and protecting the mRNA molecule for long-term storage. The purpose of the current study was to measure molecular-level dynamics as a function of temperature in the Pfizer-BioNTech COVID-19 vaccine to gain microscopic insight into its thermal stability. Materials and Methods: We used quasielastic and inelastic neutron scattering to probe (1) the vaccine extracted from the manufacturer-supplied vials and (2) unperturbed vaccine in the original manufacturer-supplied vials. The latter measurement was possible due to the high penetrative power of neutrons. Results: Upon warming from the low-temperature frozen state, the vaccine in its original form exhibits two-step melting, indicative of a two-phase morphology. Once the melting is completed (above 0 °C), vaccine re-freezing cannot restore its original two-phase state. This observation is corroborated by the changes in the molecular vibrational spectra. The molecular-level mobility measured in the resulting single-phase state of the re-frozen vaccine greatly exceeds the mobility measured in the original vaccine. Conclusions: Even a brief melting (above 0 °C) leads to an irreversible alteration of the two-phase morphology of the original vaccine formulation. Re-freezing of the vaccine results in a one-phase morphology with much increased molecular-level mobility compared to that in the original vaccine, suggesting irreversible deterioration of the vaccine’s in-storage stability. Neutron scattering can be used to distinguish between the vibrational spectra characteristic of the original and deteriorated vaccines contained in the unperturbed original manufacturer-supplied vials.
The Impact of Marathons on the Recovery of Heart Rate and Blood Pressure in Non-Professional Male Marathoners’ (≥45 Years)
Authors: Parm Ülle , Tamm Anna-Liisa , Laugamets Andras , Viigimaa Margus
Published: December 2021

Background and Objectives: Physical activity has a positive impact on health, and the participation in exercise and sports, including marathons, has increased in popularity. This kind of sport requires extreme endurance, which can cause different health problems and even lead to death. Participants without sufficient preparation and, in particular, men 45 years of age and older belong to a high risk group. The aim of this study was to determine the impact of marathons and cofactors associated with marathons on the recovery of heart rate (HR) and blood pressure (BP) of non-professional ≥ 45 years old male marathoners. Materials andMethods: A total of 136 ≥ 45 year old, non-professional (amateur marathoner), male participants were recruited. Data collection involved a questionnaire, body composition measures, and BP and HR results before and after finishing the marathon. Descriptive data, t-test, Mann–Whitney or χ2 test, and Pearson’s correlation were applied. Results: Participants (skiing n = 81, cycling n = 29, running n = 26; mean age 51.7 ± 7.1 years old) had previously attended a median of 35 (IQR 17.5–66) marathons and travelled 2111.5 (IQR 920–4565) km. Recovery of HR and BP after finishing and recovery time was insufficient and not associated with marathon preparation. Running was the most burdensome for HR, and cycling was most taxing for BP. Chronic diseases did not influence participation in the marathon. Conclusions: The preparation for the marathon was mainly sufficient, but recovery after the marathon was worrisome. Marathons are demanding for ≥45 year old males and may be too strenuous an activity that has deleterious effects on health.
Scapular Dyskinesis in Elite Boxers with Neck Disability and Shoulder Malfunction
Authors: Jung Jae Woo , Kim Young Kyun
Published: December 2021

Background and Objectives: Neck and shoulder injuries commonly occur during boxing, and scapular dyskinesis is related to those injuries. This study investigated scapular dyskinesis with neck disability and shoulder malfunction in elite boxers. Materials and Methods: Seventy-two elite boxers participated in this study. Scapular dyskinesis was evaluated as normal, subtle, and obvious. Neck disability index (NDI), shoulder internal (IR), and external (ER) range of motion (ROM), isometric strength of IR and ER, and pectoralis minor length were measured and compared with the severity of scapular dyskinesis. Results: Thirty-eight boxers (52.7%) showed scapular dyskinesis. NDI score was significantly different (normal = 3.89 ± 3.08, obvious = 7.36 ± 4.95, p = 0.025). Isometric IR strength was significantly different (normal = 10.48 ± 2.86, obvious = 8.46 ± 1.74, p = 0.01). The length of the pectoralis minor was significantly different (normal = 10.17 ± 0.67, subtle = 9.87 ± 0.79, obvious = 9.47 ± 0.85; p = 0.001), and the dominant and non-dominant arm IR ROM was significantly different (dominant = 57.43 ± 11.98, non-dominant = 64.62 ± 10.3, p = 0.001). Conclusions: The prevalence of scapular dyskinesis is high among elite boxers. Boxers with scapular dyskinesis presented shoulder malfunction as well as neck disability. Further investigation is necessary to examine the relationship between scapular dyskinesis and neck disability in boxers.
The Effects of COVID-19 on Healthcare Workers and Non-Healthcare Workers in Mexico: 14 Months into the Pandemic
Authors: Esquivel-Chirino César , Valero-Princet Yolanda , Gaitán-Cepeda Luis Alberto , Hernández-Hernández Carlos , Hernández Alejandro Macías , Laparra-Escareño Hugo , Ventura-Gallegos José Luis , Montes-Sánchez Delina , Lopéz-Macay Ambar , Hernández-Sánchez Fernando , Oliveira William Alves de , Morales-González José Antonio , Carmona-Ruiz Daniela , Rosen-Esquivel Karol , Zentella-Dehesa Alejandro
Published: December 2021

Background and Objectives: Healthcare workers (HCWs) play important roles in mitigating the COVID-19 pandemic and are more likely to become infected with COVID-19. Mexico, among other countries, had a high incidence and prevalence of cases and deaths from this disease. Material and Methods: This retrospective study evaluated the clinical characteristics as well as the geographical distribution of cases, deaths, and active cases of COVID-19 in HCWs and non-HCWs using official information from the Ministry of Health of Mexico. Results: A total of 235,343 cases of COVID-19 were reported in healthcare workers, and 2,094,191 cases were reported in non-healthcare workers. A total of 76.0% of cases in healthcare workers occurred in those who were between 25 and 50 years of age, and 71.4% of deaths occurred in those who were 50 to 69 years of age. Among healthcare workers, the most frequent comorbidities were obesity (15.2%), hypertension (10.9%), and diabetes (6.8%). Nurses were the group with the most cases (39.7%), followed by other healthcare workers (30.6%), physicians (26%), and dentists (1.6%). Physicians were the group with the most deaths (46%), followed by other professionals (30%), nurses (19%), and dentists (3%). Conclusion: These findings are likely the result of healthcare workers in Mexico being at a greater risk of exposure to SARS-CoV-2.
Assessment of Creep Properties Using Small Punch Test for a 9%Cr-Mo-Co-B Power Plant Steel
Authors: Tian Xiao , Zhang Saifei , Xu Hui , Li Taijiang , Yang Baixun , Zhang Min
Published: December 2021

The present study provides a feasible method to evaluate creep properties for a 9%Cr-Mo-Co-B power plant steel by comparing two sets of data obtained from small punch tests and conventional uniaxial creep tests. The method includes three steps: firstly, conduct a series of small punch tests and conventional creep tests in different load and temperature conditions; secondly, convert the load and central deflection data obtained from the small punch test to stress and strain data; thirdly, determinate the best fit correlation factor by comparing the two sets of data in selected creep models. It is found that two sets of data show a similar trend in stress–rupture time relation, stress–minimum strain rate relation and LMP–stress relation. The correlation factor, ksp, can effectively bridge the gap between the load in small punch test and the stress in conventional creep test. For a high-Cr martensitic heat-resistant steel named as CB2, the ksp value 1.4 can make a good prediction for rupture time, while for minimum creep rate and the Larson–Miller parameter, the ksp value 1.4 will lead a conservative prediction in the low-stress range.
CRISPR Gene Editing in Lipid Disorders and Atherosclerosis: Mechanisms and Opportunities
Authors: Walker Harry E. , Rizzo Manfredi , Fras Zlatko , Jug Borut , Banach Maciej , Penson Peter E.
Published: December 2021

Elevated circulating concentrations of low-density lipoprotein cholesterol (LDL-C) have been conclusively demonstrated in epidemiological and intervention studies to be causally associated with the development of atherosclerotic cardiovascular disease. Enormous advances in LDL-C reduction have been achieved through the use of statins, and in recent years, through drugs targeting proprotein convertase subtilisin/kexin type 9 (PCSK9), a key regulator of the hepatic LDL-receptor. Existing approaches to PCSK9 targeting have used monoclonal antibodies or RNA interference. Although these approaches do not require daily dosing, as statins do, repeated subcutaneous injections are nevertheless necessary to maintain effectiveness over time. Recent experimental studies suggest that clustered regularly interspaced short palindromic repeats (CRISPR) gene-editing targeted at PCSK9 may represent a promising tool to achieve the elusive goal of a ‘fire and forget’ lifelong approach to LDL-C reduction. This paper will provide an overview of CRISPR technology, with a particular focus on recent studies with relevance to its potential use in atherosclerotic cardiovascular disease.
The Association of Proprotein Convertase Subtilisin/Kexin Type 9 to Plasma Low-Density Lipoproteins: An Evaluation of Different Methods
Authors: Canclini Laura , Malvandi Amir Mohammad , Uboldi Patrizia , Jabnati Najoua , Grigore Liliana , Zambon Alberto , Baragetti Andrea , Catapano Alberico Luigi
Published: December 2021

Proprotein convertase subtilisin/kexin type-9 (PCSK9) is key regulator of low-density lipoprotein (LDL) metabolism. A significant proportion of PCSK9 is believed to be associated with LDL in plasma as it circulates, although this finding is still a matter of debate. The purpose of this study was to establish an experimental method to investigate the presence of such an interaction in the bloodstream. We compared a number of well-established methods for lipoprotein (LP) isolation to clarify whether PCSK9 associates differently to circulating lipoproteins, such as KBr gradient ultracentrifugation, physical precipitation of ApoB-LPs, fast protein liquid chromatography (FPLC) and iodixanol gradient ultracentrifugation. Our data show heterogeneity in PCSK9 association to lipoproteins according to the method used. Two methods, iodixanol ultracentrifugation and column chromatography, which did not involve precipitation or high salt concentration, consistently showed an interaction of PCSK9 with a subfraction of LDL that appeared to be more buoyant and have a lower size than average LDL. The percent of PCSK9 association ranged from 2 to 30% and did not appear to correlate to plasma or LDL cholesterol levels. The association of PCSK9 to LDL appeared to be sensitive to high salt concentrations. FPLC and iodixanol gradient ultracentrifugation appeared to be the most suitable methods for the study of this association.