bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative Effects of Deoxynivalenol, Zearalenone and Its Modified Forms De-Epoxy-Deoxynivalenol and Hydrolyzed Zearalenone on Boar Semen In Vitro
Authors: Tassis Panagiotis D. , Reisinger Nicole , Nagl Veronika , Tzika Eleni , Schatzmayr Dian , Mittas Nikolaos , Basioura Athina , Michos Ilias , Tsakmakidis Ioannis A.
Published: July 2022

Deoxynivalenol (DON) and zearalenone (ZEN) are described as detrimental factors to sow and boar fertility. In comparison, literature reports on the impact of modified forms of DON and ZEN, such as de-epoxy-DON (DOM-1) and hydrolyzed ZEN (HZEN), on swine reproduction are scarce. The aim of our study was to compare the effects of DON, DOM-1, ZEN and HZEN on boar semen in vitro. To this end, pooled boar semen ejaculates from two adult boars were treated with either 50.6 μM DON, 62.8 μM ZEN or equimolar concentrations of DOM-1 and HZEN, respectively (dilution volume of v/v 0.7% DMSO in all cases). Effects on semen motility, morphology, viability, hypo-osmotic swelling test reaction and DNA integrity were investigated hourly up to four hours of incubation. DON negatively affected particular parameters evaluated with a computer-assisted sperm analysis system (CASA), such as immotile spermatozoa and progressive motile spermatozoa, whereas those effects were absent in the case of DOM-1 treatment. In contrast to HZEN, ZEN affected almost all CASA parameters. Furthermore, only ZEN decreased the proportion of viable spermatozoa and increased the proportion of spermatozoa with abnormalities. In conclusion, DON and ZEN negatively affected boar semen in vitro, whereas equimolar concentrations of DOM-1 and HZEN did not induce harmful effects.
Clinical Application of Botulinum Neurotoxin in Lower-Urinary-Tract Diseases and Dysfunctions: Where Are We Now and What More Can We Do?
Authors: Kuo Hann-Chorng
Published: July 2022

Botulinum toxin A (Botox) had been considered a promising drug that has an effect on functional disorders of the lower urinary tract. Because Botox exhibits anti-inflammatory and antispasmodic effects, Botox injection into the bladder can decrease detrusor contractility, reduce bladder hypersensitivity, and eliminate painful sensations. Injecting Botox into the bladder outlet can relax the hyperactivity of the bladder neck, and of the urethral smooth and striated muscles. Based on these therapeutic effects, Botox has been widely applied to treat lower-urinary-tract dysfunctions (LUTDs) such as overactive bladder and neurogenic detrusor overactivity. However, this treatment has not been licensed for use in other LUTDs such as interstitial cystitis, voiding dysfunction due to benign prostatic hyperplasia in men, and dysfunctional voiding in women. Botox has also not been approved for the treatment of children with overactive bladder and dysfunctional voiding; in patients with spinal cord injuries with detrusor sphincter dyssynergia and autonomic dysreflexia; or for poorly relaxed external sphincter in non-neurogenic patients. This article reviews the current knowledge regarding Botox treatment for LUTDs and discusses the potential clinical applications of Botox, as well as work that can be conducted in the future.
Combination of Bacillus velezensis RC218 and Chitosan to Control Fusarium Head Blight on Bread and Durum Wheat under Greenhouse and Field Conditions
Authors: Palazzini Juan , Reynoso Agustina , Yerkovich Nadia , Zachetti Vanessa , Ramírez María , Chulze Sofía
Published: July 2022

Fusarium graminearum sensu stricto is, worldwide, the main causal agent of Fusarium head blight in small cereal crops such as wheat, barley, and oat. The pathogen causes not only reductions in yield and grain quality but also contamination with type-B trichothecenes such as deoxynivalenol. Prevention strategies include the use of less susceptible cultivars through breeding programs, cultural practices, crop rotation, fungicide application, or a combination of them through an integrated pest management. Additionally, the use of more eco-friendly strategies by the evaluation of microorganisms and natural products is increasing. The effect of combining Bacillus velezensis RC218 and chitosan on Fusarium Head Blight (FHB) and deoxynivalenol accumulation under greenhouse and field conditions in bread and durum wheat was evaluated. Under greenhouse conditions, both B. velezensis RC218 and chitosan (0.1%) demonstrated FHB control, diminishing the severity by 38 and 27%, respectively, while the combined treatment resulted in an increased reduction of 54% on bread wheat. Field trials on bread wheat showed a biocontrol reduction in FHB by 18 to 53%, and chitosan was effective only during the first year (48% reduction); surprisingly, the combination of these active principles allowed the control of FHB disease severity by 39 and 36.7% during the two harvest seasons evaluated (2017/18, 2018/19). On durum wheat, the combined treatment showed a 54.3% disease severity reduction. A reduction in DON accumulation in harvested grains was observed for either bacteria, chitosan, or their combination, with reductions of 50.3, 68, and 64.5%, respectively, versus the control.
Neurotoxicity and Other Clinical Manifestations of a Common European Adder (Vipera berus) Bite in Romania
Authors: Nițescu Gabriela Viorela , Ulmeanu Coriolan Emil , Crăciun Maria-Dorina , Ciucă Alina Maria , Ulici Alexandru , Ghira Ioan , Lonati Davide
Published: July 2022

Most cases of envenomation by common European vipers (Vipera berus) have not been reported to have neurotoxic manifestations. However, these manifestations have been demonstrated in some cases of envenomation by subspecies of V. berus, found in the Carpathian Basin region of south-eastern Europe. Here, we report the case of a 5-year-old girl from the south of Romania who presented symptoms of neurotoxicity, as well as other systemic and local symptoms, after being bitten by an adder of the V. berus subspecies. Treatment consisted of monovalent antivenom, a corticosteroid, and prophylactic enoxaparin. Neurotoxic manifestations of envenomation as well as other local and systemic symptoms improved within 5 days of treatment. The presented case shows that venom from V. berus subspecies found in the Carpathian Basin can have neurotoxic effects. This case also confirmed the efficacy of monospecific antivenom treatment in bringing about rapid and complete remission, following envenomation.
Efficient Method for Generating Point Mutations in the Vaccinia Virus Genome Using CRISPR/Cas9
Authors: Boutin Laetitia , Mosca Estelle , Iseni Frédéric
Published: July 2022

The vaccinia virus (VACV) was previously used as a vaccine for smallpox eradication. Nowadays, recombinant VACVs are developed as vaccine platforms for infectious disease prevention and cancer treatment. The conventional method for genome editing of the VACV is based on homologous recombination, which is poorly efficient. Recently, the use of CRISPR/Cas9 technology was shown to greatly improve the speed and efficiency of the production of recombinant VACV expressing a heterologous gene. However, the ability to rapidly recover viruses bearing single nucleotide substitutions is still challenging. Notwithstanding, ongoing studies on the VACV and its interaction with the host cell could benefit from viral gene targeted mutagenesis. Here, we present a modified version of the CRISPR/Cas9 system for the rapid selection of mutant VACV carrying point mutations. For this purpose, we introduced a silent mutation into the donor gene (which will replace the wildtype gene) that serves a double function: it is located in the PAM (NGG) sequence, which is essential for Cas9 cleavage, and it alters a restriction site. This silent mutation, once introduced into the VACV genome, allows for rapid selection and screening of mutant viruses carrying a mutation of interest in the targeted gene. As a proof of concept, we produced several recombinant VACVs, with mutations in the E9L gene, upon which, phenotypic analysis was performed.
Overview of Neutralization Assays and International Standard for Detecting SARS-CoV-2 Neutralizing Antibody
Authors: Liu Kuan-Ting , Han Yi-Ju , Wu Guan-Hong , Huang Kuan-Ying A. , Huang Peng-Nien
Published: July 2022

We aimed to review the existing literature on the different types of neutralization assays and international standards for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We comprehensively summarized the serological assays for detecting neutralizing antibodies against SARS-CoV-2 and demonstrated the importance of an international standard for calibrating the measurement of neutralizing antibodies. Following the coronavirus disease outbreak in December 2019, there was an urgent demand to detect neutralizing antibodies in patients or vaccinated people to monitor disease outcomes and determine vaccine efficacy. Therefore, many approaches were developed to detect neutralizing antibodies against SARS-CoV-2, such as microneutralization assay, SARS-CoV-2 pseudotype virus assay, enzyme-linked immunosorbent assay (ELISA), and rapid lateral flow assay. Given the many types of serological assays for quantifying the neutralizing antibody titer, the comparison of different assay results is a challenge. In 2020, the World Health Organization proposed the first international standard as a common unit to define neutralizing antibody titer and antibody responses against SARS-CoV-2. These standards are useful for comparing the results of different assays and laboratories.
Viral and Cellular Factors Contributing to the Hematogenous Dissemination of Human Cytomegalovirus via Polymorphonuclear Leukocytes
Authors: Braun Berenike , Laib Sampaio Kerstin , Kuderna Anna K. , Widmann Miriam , Sinzger Christian
Published: July 2022

Polymorphonuclear leukocytes (PMNs) presumably transmit human cytomegalovirus (HCMV) between endothelial cells in blood vessels and thereby facilitate spread to peripheral organs. We aimed to identify viral components that contribute to PMN-mediated transmission and test the hypothesis that cellular adhesion molecules shield transmission sites from entry inhibitors. Stop codons were introduced into the genome of HCMV strain Merlin to delete pUL74 of the trimeric and pUL128 of the pentameric glycoprotein complex and the tegument proteins pp65 and pp71. Mutants were analyzed regarding virus uptake by PMNs and transfer of infection to endothelial cells. Cellular adhesion molecules were evaluated for their contribution to virus transmission using function-blocking antibodies, and hits were further analyzed regarding shielding against inhibitors of virus entry. The viral proteins pUL128, pp65, and pp71 were required for efficient PMN-mediated transmission, whereas pUL74 was dispensable. On the cellular side, the blocking of the αLβ2-integrin LFA-1 reduced virus transfer by 50% and allowed entry inhibitors to reduce it further by 30%. In conclusion, these data show that PMN-mediated transmission depends on the pentameric complex and an intact tegument and supports the idea of a virological synapse that promotes this dissemination mode both directly and via immune evasion.
Crocodilepox Virus Protein 157 Is an Independently Evolved Inhibitor of Protein Kinase R
Authors: Rahman M. Julhasur , Tazi Loubna , Haller Sherry L. , Rothenburg Stefan
Published: July 2022

Crocodilepox virus (CRV) belongs to the Poxviridae family and mainly infects hatchling and juvenile Nile crocodiles. Most poxviruses encode inhibitors of the host antiviral protein kinase R (PKR), which is activated by viral double-stranded (ds) RNA formed during virus replication, resulting in the phosphorylation of eIF2α and the subsequent shutdown of general mRNA translation. Because CRV lacks orthologs of known poxviral PKR inhibitors, we experimentally characterized one candidate (CRV157), which contains a predicted dsRNA-binding domain. Bioinformatic analyses indicated that CRV157 evolved independently from other poxvirus PKR inhibitors. CRV157 bound to dsRNA, co-localized with PKR in the cytosol, and inhibited PKR from various species. To analyze whether CRV157 could inhibit PKR in the context of a poxvirus infection, we constructed recombinant vaccinia virus strains that contain either CRV157, or a mutant CRV157 deficient in dsRNA binding in a strain that lacks PKR inhibitors. The presence of wild-type CRV157 rescued vaccinia virus replication, while the CRV157 mutant did not. The ability of CRV157 to inhibit PKR correlated with virus replication and eIF2α phosphorylation. The independent evolution of CRV157 demonstrates that poxvirus PKR inhibitors evolved from a diverse set of ancestral genes in an example of convergent evolution.
Predictive Models of within- and between-Species SARS-CoV-2 Transmissibility
Authors: Soares Ricardo , Vieira Cristina P. , Vieira Jorge
Published: July 2022

Viruses from the Coronaviridae family have been reported to infect a large range of hosts, including humans. The latest human-infecting coronavirus, SARS-CoV-2, turned into a pandemic and subtypes with different transmissibility have appeared since then. The SARS-CoV-2 Spike (S) protein interacts with the angiotensin-converting enzyme 2 (ACE2) host receptor, and thus, in silico models, based on the structural features of the SARS-CoV-2 S protein–ACE2 receptor complex, as well as ACE2 amino acid patterns, may be used to predict the within- and between-species transmissibility of SARS-CoV-2 subtypes. Here, it is shown that at the beginning of the pandemic, the SARS-CoV-2 S protein was, as expected for a virus that just jumped the species barrier, ill-adapted to the human ACE2 receptor, and that the replacement of one SARS-CoV-2 variant by another is partially due to a better fitting of the S protein–human ACE2 complex. Moreover, it is shown that mutations that are predicted to lead to a better fit have increased in the population due to positive selection. It is also shown that the number of ACE2-interfacing residues is positively correlated with the transmissibility rate of SARS-CoV-2 variants. Finally, it is shown that the number of species that are susceptible to infection by SARS-CoV-2, and that could be a reservoir for this virus, is likely higher than previously thought.
Relative Vaccine Effectiveness of the Third Dose of CoronaVac or BNT162b2 Following a Two-Dose CoronaVac Regimen: A Prospective Observational Cohort Study from an Adult Vaccine Center in Turkey
Authors: Sonmezer Meliha Cagla , Dizman Gulcin Telli , Erul Enes , Sahin Taha Koray , Saricaoglu Tuğba , Alp Alparslan , Tanriover Mine Durusu , Uzun Omrum , Unal Serhat , Akova Murat
Published: July 2022

Coronavirus disease 2019 (COVID-19) continues to pose a threat to public health with the potential for the emergence of new variants. Vaccines are the milestones to control and slow down the damage of the pandemic. As of January 2021, a two-dose regimen with CoronaVac was authorized in Turkey. Due to the waning seroprevalence rate of SARS-CoV-2 over time, BNT162b2 or CoronaVac has been administered as the third dose following a two-dose CoronaVac regimen as a national vaccination policy. As of 14 January 2021, 5243 volunteers who received two doses of the CoronaVac vaccine at Hacettepe University Adult Vaccine Center were followed prospectively. In our study, relative vaccine effectiveness (VEff) for the third dose of the CoronaVac was 58.24% and 87.27% for BNT162b2 in preventing symptomatic COVID-19 cases. There were no hospitalizations, intensive care unit admissions, or deaths in third-dose booster groups with either BNT162b2 or CoronaVac, yielding 100% effectiveness. Both homologous or heterologous third-dose boosters provided further protection against severe COVID-19 and should be prioritized as an effective strategy to combat the COVID-19 pandemic.
The Adsorptive Removal of Bengal Rose by Artichoke Leaves: Optimization by Full Factorials Design
Authors: Khalfaoui Amel , Khelifi Mohamed Nadir , Khelfaoui Anouar , Benalia Abderrezzaq , Derbal Kerroum , Gisonni Corrado , Crispino Gaetano , Panico Antonio
Published: July 2022

Currently, the dye industry is increasing its production as a consequence of the growing need for their products in different manufacturing sectors, such as textiles, plastics, food, paper, etc... Thereafter, these industries generate very large volumes of effluents contaminated by these dyes, which require proper removal treatment before final discharge of the effluents into the environment. In this study, artichoke leaves were used as an economical and eco-friendly bio-adsorbent for Bengal Rose (BR) dye removal. Bio-adsorbent obtained from artichoke leaves was ground to powder size. The resulting powder was characterized by different methods, such as Brunauer-Emmett-Teller (BET) surface area analysis, scanning electron microscopy(SEM), X-ray Diffraction (XRD), Fourier transfer infrared (FTIR), pH at point of zero charge (pHpzc), equilibrium pH, iodine number, methylene blue number, phenol number, density, Energy dispersive X-ray spectroscopy (EDX) and Thermo-gravimetric analysis (TGA). Thereafter, the bio-adsorbent was used to study its capability for removing BR dye by testing contact time, initial concentration of dye and temperature. The results show that the saturation of bio-sorbent was reached after 40 min and the removal rate of BR dye by artichoke leaves powder (ALP) was 4.07 mg/g, which corresponds to a removal efficiency of 80.1%. A design of experiences (DOE) based on a two-level full factorial design (23) was used to study the effects of different parameters, such as pH, temperature and bio-adsorbent dosage on BR dye removal efficiency. The obtained results show that the highest removal efficiency was 86.5% for the optimized values of pH (4), temperature (80 °C) and bio-adsorbent dosage (8 g/L). Furthermore, a satisfying accordance between experimental and predicted data was observed. The kinetic and isotherm studies show that the pseudo-second order model simulated adequately the obtained data and it was found that Langmuir and Temkin isotherm models are liable and suitable for evaluating the adsorption process performance. Free energy change of adsorption (ΔG°), enthalpy change (ΔH°) and entropy change (ΔS°) were furthermore calculated to predict the nature of the adsorption process.
Deep Q-Value Neural Network (DQN) Reinforcement Learning for the Techno-Economic Optimization of a Solar-Driven Nanofluid-Assisted Desalination Technology
Authors: Jafari Sina , Hoseinzadeh Siamak , Sohani Ali
Published: July 2022

A solar-driven desalination system, featuring a single-slope solar still is studied here. For this design, Al2O3 nanofluid is utilized, and the condition achieving the highest efficiency and cost-effectiveness is found using a reinforcement learning called a deep Q-value neural network (DQN). The results of optimization are implemented for the built experimental setup. Experimental data obtained under the climatic conditions of Tehran, Iran, are employed to compare the enhancement potential of the optimized solar still system with nanofluid (OSTSWNF) with the solar still system with water (STSWWA). The hourly fluid temperatures in the basin as well as the hourly and cumulative freshwater production (HFWP and CFWP) are discussed. A number of other parameters, including daily water production and efficiency in addition to the cost per liter (CPL) of the resulting desalinated water, are also taken into account. The results reveal that annual water production increases from 1326.8 L to 1652.4 L, representing ~25% growth. Moreover, the annual average efficiency improves by ~32%, rising from 41.6% to 54.7%. A great economic enhancement is seen as well, with the CPL decreasing by ~8%, i.e., from USD 0.0258/L to USD 0.0237/L.
Insight into the Impacts and Removal Pathways of Perfluorooctanoic Acid (PFOA) in Anaerobic Digestion
Authors: Xie Hongyu , Chen Yuqi , Wang Yuzheng , Kong Zhe , Cao Wenzhi , Zhang Yanlong
Published: July 2022

Perfluorooctanoic acid (PFOA) that accumulates in wastewater and excess sludge interact with the anaerobes and deteriorate the energy recovery and pollutants removal performance in the anaerobic digestion (AD) system. However, the interaction between PFOA and microbial metabolism in the AD systems remains unclear. This study aimed to clarify the effects and mechanism of PFOA on the AD process as well as the removal pathways of PFOA in an AD system. The results showed that the methane recovery efficiency was inhibited by 7.6–19.7% with the increased PFOA concentration of 0.5–3.0 mg/L, and the specific methanogenesis activity (SMA) was inhibited by 8.6–22.3%. The electron transfer system (ETS) was inhibited by 22.1–37.3% in the PFOA-containing groups. However, extracellular polymeric substance (EPS) gradually increased due to the toxicity of PFOA, and the ratio of protein to polysaccharide shows an upward trend, which led to the formation of sludge aggregates and resistance to the toxic of PFOA. The PFOA mass balance analysis indicated that 64.2–71.6% of PFOA was removed in the AD system, and sludge adsorption was the main removal pathway, accounting for 36.1–61.2% of the removed PFOA. In addition, the anaerobes are proposed to have the potential to reduce PFOA through biochemical degradation since 10.4–28.2% of PFOA was missing in the AD system. This study provides a significant reference for the treatment of high-strength PFOA-containing wastes.
Wayside noise measurements of diesel multiple unit rail vehicles in revenue service
Authors: Towers David
Published: July 2022

Wayside noise measurements of revenue service operations of Stadler FLIRT3 Diesel Multiple Unit (DMU) rail vehicles were carried out on the Trinity Metro TEXRail commuter rail system at locations between DFW International Airport and downtown Fort Worth, TX. The objective of the measurements
was to compare measured vehicle noise levels with the noise prediction model used for the TEXRail Extension Environmental Assessment (EA). This model is based on adjustments to the results of controlled wayside noise tests previously conducted for similar Stadler diesel-electric GTW 2/6 articulated
DMU rail vehicles on the Denton County Transportation Authority (DCTA) A-Train system in Lewisville, TX. The measurement results suggest that the FLIRT3 noise model provides a conservative estimate of noise exposure from train operations and is appropriate to use for assessing the noise impact
of the TEXRail Extension.
Effects on repeatability and shape of the force pulse due to shape, height, mass, and angle of heavy/hard weight drops
Authors: Golden Matthew , Gartenburg Paul , Musafere Faiz , Strybos Jordan
Published: July 2022

Recently a simplified one-third octave band sound and vibration prediction method for heavy/hard impact has been presented. While the prediction method shows good agreement with measured results below 100Hz, there is interest in extending the range where the prediction is considered
valid. The authors hypothesize that the lack of agreement at frequencies above 100 Hz is due to low repeatability of weight drops used as the reference drop in the prediction method. First, the authors will verify previous research showing that round objects are far more repeatable than standard
gym equipment by comparing the force pulse from round objects to different orientations of commercial free weights. Second, the authors will examine the repeatability of noise generated by different mass round objects dropped from different heights in a standard floor ceiling lab. Additional
data will be shared that shows the effect of the shape of the impact foot on the generated force pulse from a laboratory based drop tower.
Coordination issues for concrete floating floors; san francisco conservatory of music bowes center, case study
Authors: Miyar Cristina , Shou Anthony
Published: July 2022

The San Francisco Conservatory of Music (SFCM) Bowes Center is a complex, vertical building housing SFCM's performance, rehearsal, instruction, and dormitory spaces. Coordination issues during design and construction that are not strictly acoustical but that are critical to achieving
the floating floor's optimum sound and impact isolation performance are discussed. This paper examines issues from early design to construction phases applicable to many types of floating floor systems, such as: setting structural point loading criteria, developing a sound isolation envelope,
coordination with audiovisual (AV) and theater consultants with respect to routing of conduits and locating recessed AV boxes in floating floor, coordination with the architect and structural engineer to identify high point loads on floating floor, consideration of seismic restraint elements,
structural coordination to evaluate anchorage needs for elements supported on floating floor, construction sequencing coordination with pre-construction contractor with respect to anticipated needs for lifts on raised floating floors, and coordination of floating floor shop drawings with framing
shop drawings for elements supported from the floating floor. This project case study outlines a useful list to help architects, consultants, and engineers navigate the complex and varied coordination issues that may arise on projects with concrete floating floors.
Electric machine noise and vibration prediction and validation through test
Authors: Chen Keyu , Hartwig Marcus , Amoozegar Shahram
Published: July 2022

In this paper, a finite element (FE) simulation process for the NVH prediction of electric motors is proposed. The proposed process first simulates the motor excitation forces using a 2D electromagnetic force model which is derived from Maxwell and then it applies these forces to a
simplified 3D electric machine model. This simplified 3D model is validated by comparing the structural transfer functions calculated from impact hammer test and FE simulation. Finally, the proposed simulation process is validated by comparing predicted sound pressure levels at different selected
locations to an electric motor NVH test results from a semi-anechoic chamber.
A finite difference approach for predicting acoustic behavior of the poro-elastic particle stacks
Authors: Mo Zhuang , Song Guochenhao , Bolton J. Stuart
Published: July 2022

The physical properties of particle stacks have been of interest for a long time, and the acoustic properties of such materials have been actively investigated in recent times. Traditional acoustic theories, such as the Biot theory, can serve as a guide for determining the general properties
of the stacks, but they do not allow the identification of the differences between the particle stacks and traditional acoustic materials, which are usually modeled as homogeneous continua. Recent research suggests that the Biot theory, combined with depth-dependent stiffness and equivalent
density, can be used to model such materials. In this work, a finite difference (FD) scheme based on the Biot theory has been developed based on the idea that the apparent stiffness of the particle stack varies with depth within of the stack. This FD scheme is two-dimensional in cylindrical
coordinates with an axisymmetric condition imposed at the axis of the cylinder. This approach is thus suitable for modeling common scenarios in which particle stacks are tested in a cylindrical standing wave tube. The results of several example cases are shown in this paper.
A different method of partition wall isolation
Authors: Herreman Kevin , Taylor Corey
Published: July 2022

Modern homes are constructed leveraging the fundamental learnings of building science. They are built for energy efficiency, thermal comfort, and more recently indoor air quality. Acoustics have also been incorporated, mostly by managing the layout of the spaces to isolate noise generating
areas from sleeping or relaxing spaces. When this is not feasible, isolation is most often achieved using resilient channel to improve the performance of partition walls. Resilient channel are required to be installed utilizing skilled and competent workers as the system is very sensitive
to installation errors. After years of studying the vibro-acoustic energy transfer mechanism in partition walls, similar isolation was determined to be achieved utilizing an alternative approach. The mechanism and a potential solution will be explored in this paper.
A proposed method for measuring noise from wind farms for the purpose of determining compliance with applicable limits and the comparison of results to ISO 9613-2 predictions
Authors: Bowers Justin , Hankard Michael , Cerjan Jeff
Published: July 2022

This paper describes methods for the measurement of noise emissions from utility-scale wind farms and the analysis of the resulting data for determining compliance with noise level limits and standards. The methods call for primarily unattended monitoring of noise levels, wind speeds,
and turbine operating conditions over many weeks, in some cases months, in order to capture the recurring maximum turbine-only noise level at a receptor (e.g., residence). This condition occurs when the nearest turbines are producing full acoustic output, while noise from background sources
is very low (particularly that from wind). This paper will present the results of noise compliance measurement studies applying these methods conducted by Hankard Environmental, encompassing over 13 projects and over 50 measurement locations in the Northeast, Midwest, and Plains regions of
the United States (U.S.) The results of these measurements are used to assess the accuracy of the ISO 9613-2:1996 method in predicting wind turbine noise levels on both an overall A-weighted and octave band basis. These results can be used by wind energy developers to accurately design projects
to meet applicable limits and standards and gives all parties in the permitting process a greater degree of confidence in predictions and compliance measurement results.
Evaluation of nighttime helicopter noise in an urban neighborhood
Authors: Hirsh AnnMarie , Babich Jeffrey
Published: July 2022

Sound level measurements were gathered at two locations within an urban neighborhood close to a helipad. A sound level meter was placed at each location for approximately one week, where data were collected continuously from 10:00 PM to 6:00 AM in fifteen-minute intervals. L90 was measured
to establish existing background levels and LAFmax was measured to capture the helicopter noise. Additionally, a sound level trigger was set up to capture details and audio recordings of elevated levels associated with helicopter flights. Due to the lengthy data collection period, care was
taken to collect as much data as needed without exceeding the storage capacity of the meter. Based on preliminary data, the trigger was set to capture only events with a minimum sound pressure level and a minimum time duration, ensuring shorter noise events not of interest (barking dogs, passing
cars, etc.) were not captured. Audio files for each sound event were used to identify helicopter events, which were confirmed by comparing timestamps with the helicopter flight logs. This case study describes the details of unattended long-term data collection for this application and evaluation
of the helicopter noise measurements.
Breakout from HVAC ductwork
Authors: Lilly Jerry , Lilly Jerry
Published: July 2022

Noise radiated by HVAC ductwork is becoming more important with the recent trend to eliminate ceilings in many office buildings. The ASHRAE Applications Handbook has provided a method for calculating breakout from ductwork since 1987. This method requires determining the duct wall transmission
loss, which is not the same at the conventional transmission loss obtained using ASTM E90 because of the shape of the duct wall and because the sound field inside the duct is not random incidence. This methodology assumes that the sound level inside the duct is the same throughout the entire
duct length, which is only approximately true for short, unlined ducts, but not always the case. In 2003 the ASHRAE Handbook presented a revised duct breakout calculation method that takes into consideration the sound attenuation with distance inside the duct, assuming that the sound level
decreases at a constant rate. The results of a 2017 ASHRAE research project studying the insertion loss versus length of acoustically lined ducts revealed that the attenuation rate is not constant with length. This paper demonstrates the difference between the various breakout calculation
methods and highlights the importance of including the attenuation rate in the analysis.
Managing construction vibrations near sensitive facilities
Authors: Brush Ethan , Newmark Marc
Published: July 2022

Construction sites can be a significant source of noise and vibration. This can be a particular concern to nearby facilities that are sensitive to noise and vibration (healthcare, laboratory, museum, data centers, etc.). Managing the impact on neighboring facilities can become a challenging
issue associated with the project. In this paper we will discuss the use of construction simulation to predict potential impact and real time monitoring to keep tabs on the construction while it is underway. We will present examples where vibration monitoring and testing, in conjunction with
planning and administrative controls, have been shown to be effective in enabling construction to move forward, even with vibration sensitive operations nearby.
The boom in life science development and its impacts on community noise
Authors: Wallace Marc , Riegert Matthew , Rosa Patricia
Published: July 2022

There is a boom in life science research and laboratory development in many areas of the country. And the speed of that development has accelerated since the COVID-19 pandemic. A life science facility may look like a traditional office building, but the sound emitted from the rooftop
mechanical equipment associated with spaces occupied by pharmaceutical and biotechnology companies is distinct. A sound study was prepared for permitting the reconstruction of a major mixed-use redevelopment in an urbanized area of greater Boston. The redevelopment included retail, office,
laboratory, residential and hotel uses amongst multiple buildings that would occur over several years. The complexity of the project required the collaboration of the developer, architectural and mechanical design teams, and acoustical consultants, to ensure that the cumulative sound impacts
from all the buildings' future rooftop mechanical equipment did not exceed the local noise ordinance once the redevelopment was completed. The sound study also allowed the buildings to later be customized for future life science tenants. This paper will present the framework developed for
each design team to allow the project to demonstrate compliance by establishing a noise budget.
Design-build case study project neon NDOT
Authors: Noel Scott , Goza-Tyner Jessica
Published: July 2022

Project Neon, a design-build (D-B) highway construction project in Las Vegas, Nevada, is the largest public works project in Nevada history. The project widened 3.7 miles of Interstate 15 (I-15) between Sahara Avenue and what is referred to as the "Spaghetti Bowl" interchange
in downtown Las Vegas. This stretch of I-15 is the busiest stretch of highway in Nevada carrying approximately 300,000 vehicles daily. Noise impacts were identified in the Environmental Impact Statement (EIS) for the project that would be abated by constructing noise barriers. The EIS noise
barriers were conceptual and were substantially refined during the D-B effort to provide the noise reductions committed to in the EIS. This paper describes some of the challenges with implementing the abatement measures into the design and lessons learned from this process.
Applying Lean Construction principles to noise mitigation design
Authors: Fennema Laura
Published: July 2022

The construction industry has fallen behind the times. Since the 1960s, construction labour productivity has decreased while all other non-farming labour efficiencies have doubled or more. 70% of projects are delivered late and over budget. Furthermore, one in five private sector work-related
fatalities are from construction accidents. Lean Construction is a program developed by the Associated General Contractors of America (AGC) to challenge the status quo on construction projects and help guide the industry to a better future. Utilizing Lean principles during the design phase
of noise mitigation projects can improve project deliverables across all industries. All stakeholders involved in the construction process have incentive to complete projects faster and at a lower cost. The opportunities to apply Lean principles are limitless. This paper focuses on the importance
of collaboration, planning, pre-construction, and supply chain management as they pertain to the engineered design process for noise mitigation. Building silencer prototypes before mass-production ensures the end user has an opportunity to provide feedback. Working backwards from milestones
and leaving detailed scheduling to the people conducting the work yields more useful/accurate plans. Pre-assembling acoustic barriers and/or delivering modular acoustic enclosures expedite site installations. Scheduling just-in-time acoustic silencer deliveries minimize site congestion.
How to Determine Fluid Management Goals during Continuous Kidney Replacement Therapy in Patients with AKI: Focus on POCUS
Authors: Beaubien-Souligny William , Trott Terren , Neyra Javier A.
Published: July 2022

The utilization of kidney replacement therapies (KRT) for fluid management of patients who are critically ill has significantly increased over the last years. Clinical studies have suggested that both fluid accumulation and high fluid removal rates are associated with adverse outcomes in the critically ill population receiving KRT. Importantly, the ideal indications and/or fluid management strategies that could favorably affect these patients are unknown; however, differentiating clinical scenarios in which effective fluid removal may provide benefit to the patient by avoiding congestive organ injury, compared with other settings in which this intervention may result in harm, is direly needed in the critical care nephrology field. In this review, we describe observational data related to fluid management with KRT, and examine the role of point-of-care ultrasonography as a potential tool that could provide physiologic insights to better individualize decisions related to fluid management through KRT.
FORMATION OF THE MAIN DIRECTIONS FOR IMPROVING APPROACHES TO ASSESSING THE FUNCTIONING OF A COMMERCIAL ENTERPRISE
Authors: Sibiryatkina Irina
Published: July 2022

The article proposes the main directions focused on improving approaches to assessing the functioning of the financial and economic activities of a commercial enterprise. The proposed directions are based on the principles of integration of financial accounting with tax accounting in the economy of a commercial enterprise. This problem is relevant, because. in the economic activity of a commercial enterprise there are unresolved contradictions caused by accounting and tax legislation. The problems of accounting and tax accounting in terms of their compatibility have their roots since the introduction of tax legislation on corporate income tax. The created contradictions lie in the plane of recognition of income and expenses of the organization according to tax and accounting data. They relate to such issues as the date of recognition of income and expenses, the method of depreciation for fixed assets, the formation of reserves, etc. The article considers approaches to the possible integration of accounting and tax accounting for commercial enterprises. To obtain conclusions on the stated topic of the publication, the method of comparison and comparison of accounting and tax accounting in business entities was used. Common features and differences in the reflection of income and expenses of an enterprise are revealed, tools for integrating ways and methods of accounting, approaches to the formation of subconto, integral accounting registers of information and tools for their adjustment based on modern information technologies are substantiated. The resulting toolkit integrates financial and tax accounting, which allows the most accurate assessment of the functioning of a commercial enterprise.
DEVELOPMENT OF SMALL AND MEDIUM-SIZED BUSINESSES IN THE ORYOL REGION IN A PANDEMIC
Authors: Polyanin Andrey , Tugacheva L. , Repichev A.
Published: July 2022

The article analyzes the current level of development of SMEs in the regional context on the example of the Oryol region; studied the features of state support for business during the COVID-19 pandemic; trends, risks and prospects for the activities of businessmen in a rapidly changing economic and political environment have been identified. Of interest is the process of transformation of restrictions due to the worsening epidemiological situation into economic restrictions of an external nature, due to the ongoing sanctions imposed against Russia by foreign states. The theoretical and methodological basis of the study was the scientific work of domestic and foreign scientists in the field of business support, focused on achieving sustainable development and ensuring import substitution. The study was based on an integrated approach, which involves the study of various aspects of entrepreneurship development, taking into account economic, social, cultural and political components. The study of materials on the stated issues was carried out by the authors using the methods of structural and system analysis, text mining. Emphasis is placed on the fact that the further development of entrepreneurship should take place in the conditions of active digitalization of processes. It was determined that the measures of state support for business during the pandemic allowed most entities to maintain their activities and further resist the impact of sanctions in the new economic conditions, using the opportunities to develop vacant market niches. Scientific novelty lies in the expansion of theoretical ideas about activities in the framework of overcoming crisis situations by SMEs at the regional level. The practical significance of the study is expressed in the systematization of regional experience in supporting SMEs and the possibility of its use by other subjects of the Russian Federation.
PROCUREMENT FORECASTING IN ENTERPRISE RESOURCE AND PLANNING (ERP) SYSTEM USING HYBRID TIME SERIES MODEL
Authors: El Madany Hassan , Alfonse Marco , Aref Mostafa
Published: July 2022

Forecasting is one of the useful applications of machine learning in Enterprise Resource Planning (ERP). This is a vital component of a business's financial planning, which projects into the future using data from the past. This study offers a novel method for anticipating purchases using time series data. Based on prior order requests, the suggested approach is utilized to determine the buy price for specified items for possible purchase orders from suppliers. The dataset used during implementation is based on a real company purchasing process extracted from the SAP Business One ERP system. The dataset contains 12 years of historical monthly procurement data. It covers the period from 2010 to 2022, having a total number of 7600 observations. The evaluation of the proposed approach is measured using the Mean Absolute Error (MAE) and Root Mean Squared Error (RSME), respectively.
COOPERATION NETWORK OF POTENTIAL TOURIST ATTRACTIONS IN THE MANAGEMENT OF INTEGRATED TOURIST DESTINATIONS IN THE BROMO TENGGER SEMERU NATIONAL PARK AREA
Authors: Irtanto  , Abror Daimul , Ratnawati Susi , Surahno Anom , Kuncoro Cahyo Yudho
Published: July 2022

The aims of this study are to 1) identify the potential of tourist attractions in four areas of Malang, Pasuruan, Lumajang, and Probolinggo in supporting the management of integrated tourist destinations in the Bromo Tengger Semeru (BTS) area; 2) identify cooperation networks between local governments (Malang, Pasuruan, Lumajang, and Probolinggo) in the management of integrated tourist destinations in the BTS area; 3) identify the cooperation model that is built in the management of integrated tourist destinations in the BTS area, and 4) develop recommendations for the cooperation model in the management of integrated tourist destinations in the Bromo Tengger Semeru National Park (TNBTS) Center area and the BTS National Strategic area. The targets in the study are the potential for tourist attractions in the four areas surrounding the BTS, the cooperation in the management of integrated tourist destinations between the TNBTS Center and each local government in the four areas around the BTS, the cooperation in the management of integrated tourist destinations among the local government of Malang Regency, the Government of the Republic of Indonesia. The Pasuruan Regency area, the Lumajang Regency government, and the Probolinggo Regency government are located in the BTS ring area, and the model was built to manage integrated destinations in the BTS ring area. The research method uses qualitative methods with in-depth interviews. Novelty in this study is a tourism network cooperation based on the local wisdom of each region by taking into account the economic potential of the four districts and the accessibility of the Catchment area.
Research activity on spatial light modulators at Hamamatsu
Authors: Hara Tsutomu
Published: July 2022

There is a lot of interest in technology that controls the phase of light two dimensionally, such as laser waveform shaping and optical phase compensation. And a spatial light modulator is highly desired for practical use of these technologies. We have developed several types of spatial light modulators for years. The history of our research and development of spatial light modulators is shown here.
Negative capacitance partially junction-less FET for hysteresis-free and improved analog performance
Authors: Kansal Harshit , Medury A. S.
Published: July 2022

Given the advantage of high transconductance (g
m) at low gate voltages (V
gs), seen in junction-less (JL) transistors, it becomes important to incorporate these advantages in conventional bulk MOSFETs which have thus far been used extensively for analog circuit applications. In this work, we propose a partially JL channel in a bulk MOSFET device, which when investigated for a metal-ferroelectric-insulator-semiconductor (MFIS) with negative capacitance field-effect transistor (NCFET) shows superior analog device performance, with improved scalability. Through technology computer aided design (TCAD)-based transient simulations, we identify an optimum and almost constant ferroelectric layer thickness for different gate lengths, which enables hysteresis-free behavior, along with reasonably steep sub-threshold slopes (SS), that meets international roadmap for devices and systems specifications. For this device, we then determine the maximum drain voltage, V
ds, which ensures no drain-induced barrier raise effects, based on which improved transconductance generation efficiency (g
m/I
d), with minimal gate induced drain leakage is shown.
Structural study of hermetic seal formed by water glass at low temperature when trapped between glass plates
Authors: Takamure Noboru , Caro Laura Granados , Fukata Naoki , Ho-Baillie Anita , McKenzie David Robert
Published: July 2022

Hermetic sealing is an important technology in applications such as packaging of MEMS, sensors and vacuum glazing. Hydrocarbon materials like cyanoacrylate “super glue” have been used for convenient sealing. However, it is known that cyanoacrylate and other hydrocarbon glues are permeable to water vapour and do not act as a hermetic seal. On the other hand, there are some hermetic sealing techniques such as anodic bonding, ultrasonic solder bonding, solder glass bonding with or without laser assistance that require high process temperatures and are of high cost. In this paper, we assess water glass for low-cost hermetic sealing of soda lime glass at low temperatures of less than 100 °C. The vacuum level in a sample encapsulation was measured by means of a spinning rotor gauge which showed no pressure increase for one year. In addition, the bonding strength was also measured, showing that the 80 °C annealing process is the best process temperature for the highest adhesion strength.