bluuebunny/crossref_metadata_2025 huggingface dataset:
Meeting the Grand Challenges in a Rural Community
Authors: Giesler Fredi , Rieske Robert , Wuthrich Lacey , Ashley Tara
Published: September 2020

Three of the Grand Challenges identified by the social work profession are specifically related to health care: healthy youth development, closing the health care gap, and advancing long and productive lives. Idaho State University (ISU) initiated a collaborative interprofessional health education project (IET) over 30 years ago. This collaborative includes ten health care disciplines across five colleges and provides in-depth assessment and referral to three families annually. This study describes the development of a collaborative, high impact, teaching exemplar, and examines the knowledge, perceptions, and competency of participating students using the framework of the IPEC competencies and the CSWE practice competencies for social work education. Results are derived from a pre-post survey administered during the previous two years. The project includes two groups of students: those that engaged in a hands-on experience with a client and those that only observed clients. The Observation-Only group completed the SPICE-R2 and the IEPS. Students that had direct interaction with clients completed the IEPS (pre-post engagement with clients) as well as the ICCAS. Attitudes, perceptions, and perceived competency improved amongst students participating in the IET course from pre-assessment to post-assessment with moderate to large effects being observed.
Leveraging the Power of Social Work through Interprofessional Education
Authors: Rubin Maureen , De Saxe Zerden Lisa , McGuire Lisa E.
Published: September 2020

Interprofessional education (IPE) “occurs when students from two or more professions learn about, from and with each other to enable effective collaboration and improve health outcomes” (World Health Organization [WHO], 2010). With a commitment to foster collaborative practice, social work faculty have provided leadership in incorporating IPE in social work and other discipline’s curricula and training for more than a decade (Konrad et al., 2017; Nimmagadda & Murphy, 2014; Jones & Phillips, 2016). Yet, now more than ever, as the country and world grapple with responding to the COVID-19 pandemic and the resultant deleterious impacts on society, effective collaboration has never been more critical. Likewise, the Black Lives Matter (BLM) movement has impacted the nation as the country reckons with racial and social disparities across every sector of society. The impetus for this special issue pre-dated the COVID-19 and BLM momentum; however, the 19 papers included in this special issue highlight the interconnected nature of social conditions across systems that necessitate interprofessional, coordinated responses. This special issue reinforces the importance of collaboration, teamwork, inclusivity, and diversity. The power of social work, in partnership with other professions and/or disciplines, in communities locally and globally is essential to effectively meeting some of society’s greatest challenges.
Trauma Sex: A Queercrip Erotic
Authors: Smilges J. Logan
Published: September 2020

Sometimes sex is really fucking hard. Pun intended. This essay explores the role of trauma in sex, arguing that experiences of trauma can reconstitute the erotic in ways that are incompatible with prevailing discourses on queerness, consent, and sexual violence. "Trauma sex" is a way of capturing the queer and crip flavors of this erotic reconstitution by demonstrating how many of us experience sex, sexuality, and desire in ways that go unremarked on by disability and queer studies, independently. Grounded in "conscientious intimacy," trauma sex brings together disability and queer studies to call for an opening up of desire, a radical expansion of what we acknowledge as sex, sexual, and sexy, by attending to the troubling absence of disability from queer theory, of trauma from disability studies, and of the inadequate attention to race and processes of racialization in both fields. Sex and trauma are complicated, this essay suggests, so our conversations about them should be too.
Analysis on Corporate Financial Engineering and Financial Management Innovation
Authors: Liu Yuxuan
Published: September 2020

Corporate financial engineering refers to the use of advanced mathematical and communication techniques to solve financial problems for the maximization of company’s own interests. The techniques are used for innovative designs regarding financial tools and means, and also for devising and implementing financial products. As for corporate financial management, it is the basic guarantee for operating a company. For both the company and its internal and external activities, the support from financial management is inseparable. Financial management is an important link to balance the benefits and costs generated in the process of corporate operation. This article analyzes and explores the effects of the application of financial engineering in financial management.
Destinos turísticos e a sua relação com o processo de cocriação de valor e o marketing de experiência: uma revisão bibliográfica
Authors: Paes Taís Alexandre Antunes , Ladeira Rodrigo , Larocca Maria Teresa Grimaldi
Published: September 2020

A atividade turística envolve uma complexidade de relações que abrange variados atores sociais em um destino turístico. Os turistas e os visitantes se destacam ao buscarem experiências turísticas memoráveis, sendo cocriadores das suas próprias experiências ao visitarem uma localidade. O presente estudo caracteriza-se por ser uma revisão bibliográfica que visa abordar aspectos sobre a atividade turística, destinos turísticos, cocriação de valor e o marketing de experiência, baseado em alguns dos principais estudiosos sobre os temas: co-criação (Vargo & Lusch, 2008; Payne et al., 2008) e marketing de experiência (Schmitt, 1999, 2002, 2006, 2010; Smith & Hanover, 2016). Para tal, foi realizada uma pesquisa bibliográfica sendo este trabalho de natureza exploratória e descritiva. Observa-se a necessidade de as localidades turísticas trabalharem em um planejamento integrado considerando o setor público, privado e a comunidade local, buscando devolverem atrativos e serviços turísticos consistentes com boas experiências turísticas.
Gestão pública em turismo: coordenação e comunicação no processo de inventário da oferta turística
Authors: Trentin Fábia , Fonseca Filho Ari Da Silva
Published: September 2020

A coordenação de políticas públicas tem sido amplamente discutida nas Ciências Sociais devido à dificuldade de coordenar os diferentes atores envolvidos no processo. Coordenação e comunicação são as bases teóricas utilizadas para interpretar algumas dificuldades na implementação do Projeto de Inventário da Oferta de Turismo do Estado do Rio de Janeiro (IOT-RJ). Nesse sentido, o objetivo deste artigo foi compreender o processo de coordenação na execução do IOT-RJ, a fim de identificar falhas e aprendizagens no contexto do projeto. A metodologia é qualitativa, cujos dados foram coletados a partir dos relatórios do projeto e por meio de entrevistas semiestruturadas. Para analisar as informações coletadas, utilizamos os conceitos de “coordenação” e “comunicação” no âmbito teórico da gestão pública. Os resultados revelaram que as principais limitações estão relacionadas às fragilidades da coordenação vertical e horizontal e da comunicação organizacional. Os principais aprendizados identificados no projeto referem-se à compreensão da dinâmica da gestão pública com vistas à contratação por meio de licitação, execução contratual, prazos, orçamento e planejamento e articulação política à necessidade de melhores estratégias de comunicação, destacando a importância da coordenação.Palavras chave: Coordenação e comunicação; Gestão Pública; Inventário da Oferta Turística; IOT-RJ; Estado do Rio de Janeiro.
IMPACT OF COVID-19 PANDEMIC ON ACCEPTANCE OF E-LEARNING SYSTEM IN JORDAN: A CASE OF TRANSFORMING THE TRADITIONAL EDUCATION SYSTEMS
Authors: Al-Okaily Manaf , M Alqudah Hamza , Matar Ali , Lutfi Abdalwali , Taamneh Abdallah
Published: September 2020

Purpose of the study: This paper aimed at investigating factors influencing students’ intention to use e-learning within the context of Jordan. The proposed model integrated subjective norms with the extended Technology Acceptance Model (TAM).

Methodology: The data collected 587 students from Jadara University. Data were analyzed using Partial Least Squares - Structural Equation Modelling (PLS-SEM).

Main Findings: The result has confirmed the direct effect of all variables. Next, the result has also shown that the mediation effect of perceived usefulness and perceived ease of use between subjective norm and the behavioral intention to use the E-learning system was partially supported.

Applications of this study: The results of the current work may contribute to the improvement of the existing literature in the e-learning acceptance fields, and can be applied as an essential input for the development of the recent e-learning training programs.

Novelty/Originality of this study: The present work is intended to conclude a series of concrete research data as well as to contribute a new angle to the existing literature on students’ perception of the e-learning system.
FLEXIBLE INFLATION TARGETING AND INFLATION PERSISTENCE IN INDONESIA: THE TRADITIONAL UNIVARIATE AND FRACTIONAL INTEGRATED UNIVARIATE APPROACHES
Authors: Zainuri Zainuri , Fasa Muhammad Iqbal , Panjaitan Roymon , Athief Fauzul Hanif Noor
Published: September 2020

Purpose of the study: The high degree of inflation persistence will impact the Indonesian economy. The purpose of this study is to determine the degree of inflation persistence in Indonesia following the adoption of a flexible Inflation Targeting Framework (ITF).

Methodology: Traditionally integrated univariate and fractional approach will be carried out in this research. The inflation variables used are core inflation, administered price inflation, volatile inflation, and general inflation. The data used is from 2014M1 to 2019M2.

Main Findings: After data analysis, the researchers found that high persistence behaviors are found, especially in the core, administered, and volatile inflation, following the flexible adoption of the ITF. The time it takes for inflation to return to equilibrium is 1 to 8 months for each group.

Applications of this study: The result is important for the highest authorities in improving their policy. Structural improvements through monetary policy based on inflation expectations, increasing the transparency of food prices, and synergy with Central as well as Regional Inflation Control is suggested for the authorities.

Novelty/Originality of this study: This study presents a different perspective of research within the inflation topic. It takes the recent policy implementation of a country and analyses its effect. To the best of the authors knowledge, this research is the first to explain the effect of the Inflation Targeting Framework on Indonesia's inflation condition.
Philosophical Approach to the Statutory Drafting
Authors: Škop Martin
Published: September 2020

This article traces the relationship between the law-making process and narratives. Undoubtedly, how statutes are created is a constitutional question, yet the Constitution regulates only part of this process. Constitution or any statute does not regulate parts of the legislative process implemented by the government (mostly preliminary phases). However, they are important and influence the remaining parts of the law-making process. This government’s activity is the sphere of informal regulation hidden from the primary control of the public. This article explores the importance of the bureaucratic elements of the law-making process with emphasis on a narrative approach: narratives justify legislature. How can we overcome the two lines of narratives – one produced by global capital and the other represented by national experience?
Ciências humanas e a esfera pública: uma perspectiva pragmática
Authors: Vershueren Jef
Published: September 2020

Este artigo parte das observações de que (i) todo uso de linguagem combina, inevitavelmente, significado explícito e implícito e (ii) todas as línguas têm meios estruturais à sua disposição para marcar significado implícito. Isso parece uma espécie de paradoxo pragmático: se é possível falar sobre “marcadores de implicatura” (um nome geral para todas as construções tradicionais portadoras de pressupostos e implicações, assim como de estratégias geradoras de implicaturas), estamos ainda lidando com implicatura? Adicionalmente, que (i) implicatura absoluta não existe (na medida em que existe, não podemos dizer nada sobre ela), (ii) explicatura e implicatura não são, portanto, opostos absolutos, e (iii) no grau em que a explicatura de marcadores de implicatura (ou “gatilhos” para processos inferenciais que levam a uma compreensão de significado não explicitamente declarado) é bastante variável, buscar-se-á uma solução descritiva e explicativa ao problema do aparente paradoxo em uma matriz tridimensional para explicar a implicatura.
Relevância, conciliação de metas e polidez
Authors: Niero Gabriela , Rauen Fábio José
Published: September 2020

Este trabalho apresenta um panorama de propostas de tratamento pragmático-cognitivo de fenômenos de polidez comunicacional orientadas pela noção teórica de relevância de Sperber e Wilson (1986, 1995). Para dar conta desse objetivo, revisam-se as perspectivas de Escandell-Vidal (1996; 1998), Jary (1998), Ruhi (2008) e Chen (2014). O ensaio analisa potencialidades e fragilidades dessas abordagens no contexto de um estudo mais amplo que trata de fenômenos de polidez, tal como propostos por Brown e Levinson (1987), a partir da tríade de intenções – comunicacional, informacional e prática – desenvolvidas pela Teoria de Conciliação de Metas de Rauen (2014).
The Efficacy of Topical Combination Amniotic Membrane Stem Cell Metabolite Product (AMSC-MP) and Vitamin E after Microneedling in Photoaging
Authors: Ardhaninggar Agatha Anindhita , Murtiastutik Dwi , Sawitri Sawitri , Prakoeswa Cita Rosita Sigit
Published: September 2020

Background: Photoaging, also called extrinsic aging, is a premature skin aging mainly resulting from prolonged and extended exposure to ultraviolet (UV) radiation. Amniotic Membrane Stem Cell Metabolite Products (AMSC-MP) are derived from amniotic membranes that contain cytokines and growth factors that have a role in the skin rejuvenation process. Vitamin E is an antioxidant that has a photoprotective effect, so it is expected to reduce the appearance of clinical signs of photoaging. Not only having skin rejuvenation effect, but microneedling is also expected to facilitate the penetration to increase the efficacy of AMSC-MP and vitamin E. This combination is expected to have a better effect on clinical photoaging improvement. Purpose: To evaluate the effect of a topical combination of AMSC-MP and vitamin E after microneedling on the clinical improvement of photoaging compared to previous skin conditions. Methods: Thirty adult women with photoaging topically administered a combination of AMSC-MP and vitamin E after 3 microneedling sessions at 2 weeks intervals. The evaluation of the improvement of the degree of pores, wrinkles, skin tone and dark spots were performed with the Janus-II Facial Skin Scope System. Result: There was a clinical improvement with a statistically significant difference in terms of the degree of pores, wrinkles, polarized black spots, and UV black spots, which were statistically significant differences (p <0.05). Conclusion: The administration of a topical combination of AMSC-MP and vitamin E after microneedling provided clinical improvement in photoaging as supported by the results of Janus analysis of pores, wrinkles, skin tones, polarized black spots, and UV black spots.
THE PROFILE OF CHILDREN WITH CONGENITAL RUBELLA SYDROME SUFFERING FROM HEARING DISORDERS IN DR SOETOMO GENERAL HOSPITAL, SURABAYA
Authors: Kesuma Raudhatuzzahra , Ekorini Haris Mayagung , Yuliawati Tri Hartini
Published: September 2020

Background: Congenital Rubella Syndrome (CRS) is an infection that can cause hearing loss which is commonly found in infants in Indonesia. The hearing screening of otoacoustic emission (OAE) and automated auditory brainstem response (AABR) is essential as an early screening to prevent speech and language development disorders which may reduce the social function of the patient in the future. Objective: To analyse the profile of children with CRS who suffer from hearing loss in Dr. Soetomo General Hospital, Surabaya in 2015-2017. Material and Method: This research employed a descriptive retrospective study by collecting 118 secondary data from the medical records. Result. CRS was mostly found in 0-3 months age group (76 patients), and was dominated by males (62 patients). The most common signs and symptoms were congenital heart disease (49 patients), followed by hearing loss (37 patients). The serological results were mostly dominated by negative IgM and positive IgG (40 patients). The most dominant results of hearing screening test were OAE and AABR bilateral refer (45 patients). Conclusion. The result of the CRS study is different, and depends on which country the research is conducted.
HIV/AIDS-RELATED FACTORS AMONGST THE LGBTQ PEOPLE IN SURABAYA
Authors: Wiratama Ridhwan Biosia , Handayani Samsriyaningsih , Soetjipto Soetjipto
Published: September 2020

Background: Acquired Immunodeficiency Syndrome (AIDS) is one of the diseases that cause death in the world caused by the Human Immunodeficiency Virus (HIV). Since it was first discovered in 1987 until December 2017, the number of person with AIDS was 102,667, and the number of person with HIV infections was 280,623. HIV/AIDS cases in East Java occupy the second highest position in Indonesia. Surabaya is the first city in East Java with 934 HIV cases in 2017. LGBTQ is one of the groups at risk of getting HIV/AIDS with prevalence was 24.82%. Objective: The purpose of this study was to analyze the factors that influence LGBTQ related to the incidence of HIV/AIDS in Surabaya. Material and Method:  This study was an analytic research using a cross sectional approach. The subject was 80 LGBTQ respondents. Data was collected using questionnaires then analyzed using Chi-square test, with α = 0.05. Result:  The highest age group was 42-46 years (22.5%), the last level of education was dominated by high school (41.3%), and the most types of work were private employees (47.4%). There was no correlation between predisposing factors in the form of knowledge about HIV/AIDS and respondent's HIV status (p = 0.729), there was no correlation between enabling factors in the form of condoms and respondent's HIV status (p = 0.624), there was no correlation between the reinforcing factor in the form of family support with the HIV status of the respondent (p = 0.674) and there was no correlation between preventive behavior and the HIV status of the respondent (p = 0.540).  Conclusion: The need for support between LGBTQs for the dangers of HIV/AIDS and LGBTQ should be more aware of their own health and environment with their social patterns
ATUAÇÃO DO NUTRICIONISTA NA ESTRATÉGIA SAÚDE DA FAMÍLIA: UMA REVISÃO INTEGRATIVA
Authors: Ferreira Francisco Valdicélio , Railene de Lima Cunha Linhares Antônia Maria , Albuquerque. Rosalice Araújo de Sousa , Boto Edilayne Gomes
Published: September 2020

O conceito de saúde tem transformado o modelo hospitalocêntrico e reabilitador por uma proposta inovadora, interdisciplinar com foco na promoção de saúde. Com isto a inserção da equipe multiprofissional na estratégia saúde da família tem sido essencial para a reorganização da atenção básica, visto que varias condições como a de alimentação e nutrição constitui um dos direitos fundamentais, sendo o nutricionista protagonista participativo. A partir disto investigou-se nas publicações a atuação do nutricionista da estratégia saúde da família através de uma revisão integrativa com caráter descritivo e abordagem qualitativa. Selecionou-se um total de 10 artigos para formar o corpo do estudo de acordo com os critérios utilizados. Verificou-se que o nutricionista na estratégia saúde da família teve maior destaque após a criação do Nasf no qual passou a atuar de forma multiprofissional. Notou-se que as principais atribuições no nutricionista estão direcionadas em várias dimensões, individual, coletiva e/ou comunitária, como a realização de varias atividades além da organização dos programas do sistema de vigilância alimentar e nutricional. Concluiu-se que as ações aqui encontradas fortalecem a consolidação da categoria nutrição enquanto ciência da saúde bem como a sua importância para o cuidado e promoção da saúde da comunidade.
ATIVIDADE FÍSICA E SAÚDE
Authors: Calazans Rhaissa , De Medeiros Cabral Gabriela , Magalhães Neto Dimas
Published: September 2020

A manutenção da saúde física, mental e social é alicerçada na prática regular de atividade física e a uma alimentação saudável, no qual este benefício se estende para a prevenção de doenças crônicas não transmissíveis. Ao analisar este aspecto na população de países em desenvolvimento observa-se um crescente número de adolescentes sedentários, com um perfil dietético rico em produtos hipercalóricos com predominância de alimentos ultraprocessados, o que gera grande preocupação, pois estes hábitos tendem a se perpetuar na vida adulta. Cientes dos malefícios que a inatividade física associada ao consumo de alimentos nutricionalmente pobres podem causar à saúde, algumas ações sociais estão sendo difundidas dentro das Universidades a fim de promover uma mudança no estilo de vida dos jovens, vislumbrando uma melhor qualidade de vida, impactando positivamente tanto seu rendimento estudantil, quanto no incentivo a perpetuação dessas práticas favorecendo a promoção a saúde o que resulta na prevenção de doenças facilmente evitáveis.
Los huertos urbanos como estrategia de transición urbana hacia la sostenibilidad en la ciudad de Málaga
Authors: Larrubia Vargas Remedios , Natera Rivas Juan José , Carruana Herrera David
Published: September 2020

La agricultura urbana es un fenómeno emergente desde hace varias décadas. Es una actividad que aporta nuevos significados a la práctica agrícola, más allá del aspecto productivo, dotándola de una función social para distintos grupos de población. Al mismo tiempo también resulta una oportunidad de recuperación de espacios abandonados, dotándoles de nueva identidad en la ciudad. En este contexto, la presente investigación se enmarca en la ciudad de Málaga donde se ha inventariado 19 huertos urbanos, promovidos tanto por organismos públicos como privados. Su análisis se ha basado en una red de entrevistas realizadas a los promotores de estos huertos a fin de subrayar sus rasgos más sobresalientes en cuanto a funcionamiento, características socioeconómicas de los usuarios, gestión, motivaciones y tipología existente. Los resultados ponen de manifiesto no sólo la diversidad de proyectos existentes sino también los beneficios que aportan al desarrollo personal de los usuarios, a la economía familiar y al entorno urbano.
Arrhythmia in the Amazon: La Niña influence on riverine organic molecular signatures
Authors: Kurek Martin , Stubbins Aron , Drake Travis , Moura Jose Mauro , Holmes Robert , Osterholz Helena , Dittmar Thorsten , Peucker-Ehrenbrink Bernhard , Mitsuya Miyuki , Spencer Robert
Published: September 2020

As climate-driven El Niño Southern Oscillation (ENSO) events are projected to increase in frequency and severity, much attention has focused on impacts regarding ecosystem productivity and carbon balance in Amazonian rainforests, with little attention given to carbon dynamics in fluvial ecosystems. We compared the wet 2012 La Niña period to the following normal hydrologic period in the Amazon River. Elevated water flux during the La Niña was accompanied by dilution of inorganic ion concentrations. Furthermore, the La Niña period exported 2.77 TgCyr-1 more dissolved organic carbon (DOC) than the normal period, an increase greater than annual Mississippi River DOC export. Using ultra-high-resolution mass spectrometry, we detected both seasonal and inter-annual variations in dissolved organic matter (DOM) compositions, revealing that DOM exported during the dry season and the normal period was more aliphatic, whereas compounds in the wet season and following the La Niña event were more aromatic, with ramifications for its environmental role. Furthermore, compounds were highly correlated to a 6-month lag in Pacific temperature and pressure anomalies, demonstrating that ENSO events impact DOM compositions exported to the Atlantic Ocean.
Identification of Novel Hub Genes Associated With Gastric Cancer Using Integrated Bioinformatics Analysis
Authors: Lu Xiao-Qing , Zhang Jia-qian , Qiao Jun , Zhang Sheng-Xiao , Qiu Meng-Ting , Liu Xiang-Rong , Chen Xiao-Xia , Gao Chong , Zhang Huan-Hu
Published: September 2020

Background: Gastric cancer (GC) is one of the most common solid malignant tumors worldwide with a high-recurrence-rate. Identifying the molecular signatures and specific biomarkers of GC might provide novel clues for GC prognosis and targeted therapy.Methods: Gene expression profiles were obtained from the ArrayExpress and Gene Expression Omnibus database. Differentially expressed genes (DEGs) were picked out by R software. The hub genes were screened by cytoHubba plugin. Their prognostic values were assessed by Kaplan–Meier survival analyses and the gene expression profiling interactive analysis (GEPIA). Finally, qRT-PCR in GC tissue samples was established to validate these DEGs. Results: Total of 295 DEGs were identified between GC and their corresponding normal adjacent tissue samples in E-MTAB-1440, GSE79973, GSE19826, GSE13911, GSE27342, GSE33335 and GSE56807 datasets, including 117 up-regulated and 178 down-regulated genes. Among them, 7 vital upregulated genes (HMMR, SPP1, FN1, CCNB1, CXCL8, MAD2L1 and CCNA2) were selected. Most of them had a significantly worse prognosis except SPP1. Using qRT-PCR, we validated that their transcriptions in our GC tumor tissue were upregulated except SPP1 and FN1, which correlated with tumor relapse and predicts poorer prognosis in GC patients.Discussion: We have identified 5 upregulated DEGs (HMMR, CCNB1, CXCL8, MAD2L1, and CCNA2) in GC patients with poor prognosis using integrated bioinformatical methods, which could be potential biomarkers and therapeutic targets for GC treatment.
Multi-Factor Analysis of the Influence of Orthokeratology on Controlling Myopia in Adolescents
Authors: Wen Shijin , Ma Siqi , Xiao Chuchu , Hu Shengfa , Ran Xufang , Tan Xingping , Xia Xiaobo , Zhou Xia
Published: September 2020

Background To investigate which baseline factors are predictive for axial length growth over an average period of 1 years in a group of adolescents wearing orthokeratology (OK) contact lenses.Methods In this retrospective study, the clinical records of 189 new OK wearers (378 eyes) between 2014 and 2018 at Xiangya Hospital of Central South University were reviewed. The primary outcome measure was axial length change from baseline to the time of 1 year. Independent variables included baseline measures of age at initiation of OK wear, refractive error (spherical equivalent), corneal thickness, corneal curvature. (1) Age group, 8 ~ 10 years old is the first group, 10 ~ 13 years old is the second group, ≥13 years old is the third group; (2) Myopia degree group, ≥-3.00D is the first group, -3.00 ~ -6.00D is the second group, <-6.00D is the third group; (3) corneal thickness group, ≤550μm is the first group,> 550μm is the second group; (4) corneal curvature group, ≤42.0D is The first group, 42.0 ~ 44.0D is the second group,> 44.0D is the third group.Results ANOVA was used to analyze the difference between the baseline axial length of each group and the axial length for 1 year after continuous wearing of orthokeratology: (1)The mean axial difference between different age groups are 0.251mm, 0.033mm,and 0.112mm, and the difference of the three groups is not statistically significant (F=2.279，P=0.104). By pairwise comparison, only the difference between the first group and the third group is statistically significant (P=0.041); (2) The mean axial difference between different myopia degree groups are 0.173mm, 0.109mm and -0.008mm, and the difference of the three groups is statistically significant (F=8.340，P=0.000 ). By pairwise comparison, the difference between the first group and the second group is statistically significant (P=0.000) and the difference between the first group and the third group is statistically significant(P=0.016); (3) The mean axial difference between different corneal thickness groups and corneal curvature groups is not statistically significant.Conclusions OKs are effective in controlling axial length elongation and myopic progression in adolescents, particularly in younger children with higher myopia.
Effects of Pre-Operative Air-Powder Polishing and Rubber-Cup Prophylaxis on Tooth Bleaching Outcomes: Randomized Controlled Split-Mouth Clinical Study
Authors: kurklu zeliha gonca bek , ozcan mustafa
Published: September 2020

Background: The aim the study to compare the effects of pre-operative air-powder polishing and rubber-cup prophylaxis on tooth bleaching outcomes.Methods: 23 subjects suffering from discoloration, were enrolled in a randomized controlled split mouth experimental study. Before bleaching, air powder polishing and rubber-cup polishing techniques were applied on either side of the mouth and the tooth bleaching effects assessed immediately after and 7 days.Results: No statistically significant difference was found in for DL, Da, Db, DE and DSGU values between air-powder polishing and rubber-cup groups at immediate and 1 week.The difference between immediate and 1 week measurements is statistically significant in both air-powder polishing and rubber-cup groups, except DL for rubber-cup group, and Da, Db for air-powder polishing group.Conclusions: Within the limitations of the study, it can be concluded that there was no lasting difference in tooth bleaching effects between rubber-cup and air-polishing techniques at immediately after and 1-week post treatment.Trial registration: ClinicalTrial.gov ID: NCT04407910
Accurate Location of Bone Tunnel in Reconstruction of Coracoclavicular Ligament Based on Three-Dimensional Printing Navigation Module Technology: Virtual Model Vs. Real Model
Authors: Zhang Lei , Wang Guo-You , Jin Yu-Feng , Xiong Lu-Jing , He Si-Yuan , Yi Gang , Zhou Xin
Published: September 2020

Background: Reconstruction of coracoclavicular (CC) ligament has become a fundamental surgical method for acromioclavicular (AC) joint dislocation. Finding accurate location of bone tunnel is a key step in reconstruction of CC ligament. This study aims to explore accurate location of bone tunnel in reconstruction of CC ligament in virtual model vs. real model based on 3-dimensional (3D) printing navigation module technology. Methods: Eighty human shoulders including clavicle and scapula were scanned by dual-source computed tomography (CT). CT scans of shoulder joints including clavicle and scapula were imported and repositioned by Mimics 19.0 software to form a whole model, then find the best bone tunnel through digital optimization design. Next, in Mimics 19.0 and Geomagic Studio software, form the clavicle navigation module as virtual model for 3D printing, thus generate real model. Then 10 parameters of a real bone tunnel and virtual bone tunnel could be measured and compared.Results: Eighty human shoulders including clavicle and scapula were designed and printed successfully. Then 10 parameters of the real and virtual bone tunnel were recorded and compared. No difference was significantly found between the real and virtual bone tunnel in 10 parameters (p>0.05). Conclusions: Based on 3D printing navigation module technology, it was reliable to determine accurate location of bone tunnel for reconstruction of CC ligament, which could reduce the complications.
Diagnosis of a Deep-Seated Intermuscular Angiolipoma Between the Trapezius and Rhomboid Major Muscles
Authors: Adewale Adesanya Olamide , Okeniran Olatayo Segun , Ssempijja Fred , Afodun Adam Moyosore , Olakunle Ojewale Abdulfatai , Ayuba John Tabakwot , Pius Theophilus , Anaya Amnia Diaz
Published: September 2020

Background: Lipomas are benign tumors contributing 1% of tumors, and 50% of soft tissue tumors. They are usually in subcutaneous tissues, deeply-seated lipomas are rare. To our knowledge, this is one of the few cases of intermuscular lipomas around East Africa. The purpose of this study was to describe the gross and microscopic features of a deep-seated lipoma and its clinical anatomy in the context of a live person.Method: This was an experimental qualitative and quantitative study on specimen from an adult cadaver at the Laboratory of the Department of Human Anatomy of Kampala International University, Western Campus. The lipoma was examined in situ, then excised, measured, weighed, then routine histological tissue processing and examination done.Results: A capsulated homogenous yellow mass was located between the trapezius muscle above and the rhomboid major muscle below, with its prominent blood supply as a continuation of the dorsal scapular blood vessels from the rhomboid. Its weight was 47.03 g, with 8.5 cm x 6.6 cm x 1.7 cm (length, width, and thickness). Microscopic analysis shows mature fat cells and prominent blood vessels (angiogenic blood invasion). Conclusions: This is one of the few cases of intermuscular angiolipomas, may cause severe clinical features due to vessel impingement to adjourning soft tissues, muscles, and joints if the growth continued undiscovered, unabated and treatment not offered on time. Further studies are recommended to establish the aspects of medical, treatment/interventions, family, and psychosocial history, and outcome regarding intermuscular angiolipomas in patients.
Chloroplast Phylogenomic Analyses Resolve Multiple Origins of the Kengyilia Species via Independent Polyploidization Events
Authors: chen shiyong , Yan Hao , Sha Li-Na , Chen Ning , Fan Xing , Zhou Yong-Hong
Published: September 2020

Background Kengyilia is a group of allohexaploid species that arose from two hybridization events followed by genome doubling of three ancestral diploid species with different genomes St, Y and P in the wheat tribe. Estimating phylogenetic relationship in resolution of the maternal lineages has been difficult, owing to the extremely low rate of sequence divergence. Here, phylogenetic reconstructions based on the plastome sequences were used to explore the role of maternal progenitors in establishment of Kengyilia polyploid species.ResultsThe plastome sequences of 11 Kengyilia species were analyzed together with 11 tetraploid species (PP, StP, and StY) and 33 diploid taxa representing 20 basic genomes in the Triticeae. Phylogenomic analysis and genetic divergence patterns suggested that (1) Kengyilia is closely related to Roegneria, Pseudoroegneria, Agropyron, Lophopyrum, Thinopyrum, and Dasypyrum; (2) both the StY genome Roegneria tetraploids and the PP genome Agropyron tetraploids severed as the maternal donor during the speciation of Kengyilia species; (3) the different Kengyilia species derived their StY genome from different Roegneria species.ConclusionMultiple origins of species via independent polyploidization events have occurred in the genus Kengyilia, resulting in a maternal haplotype polymorphism. This helps explain the rich diversity and wide adaptation of polyploid species in the genus Kengyilia.
Peptide targeting of the lysolipid-sensing GPR55 for osteoclastogenesis tuning
Authors: Mosca Maria Giovanna , Mangini Maria , Barba Pasquale , Mariggiò Stefania
Published: September 2020

Background: The G-protein-coupled receptor GPR55 has been implicated in multiple biological activities, which has fuelled interest in its functional targeting. Its controversial pharmacology and the regulation often species dependent impacted the potential translation of preclinical data involving GPR55.Results: With the aim to identify novel GPR55 regulators, we have started investigating the lysophosphatidylinositol (LPI)-induced GPR55-mediated signal transduction. HeLa cells silenced for their endogenous receptor, by stable expression of a short-hairpin RNA specific for GPR55 5’-UTR, were the expression system for wild-type and mutated GPR55 that allowed the definition of the requirement of GPR55 Lys80 for LPI-induced MAPK activation and receptor internalisation. In RAW264.7 macrophages, GPR55 pathways were investigated by Gpr55 silencing using small-interfering RNAs, demonstrating that LPI increased intracellular Ca2+ levels and induced actin filopodium formation through GPR55 activation. Furthermore, LPI/GPR55 axis was shown to have an active role in the osteoclastogenesis of precursor RAW264.7 cells induced by the ‘receptor-activator of nuclear factor kappa-B ligand’ (RANKL). Indeed, this differentiation into mature osteoclasts was associated with 14-fold increase in Gpr55 mRNA levels. Moreover, GPR55 silencing or antagonism impaired the RANKL-induced transcription of the osteoclastogenesis markers: ‘nuclear factor of activated T-cells, cytoplasmic 1’, matrix metalloproteinase-9, cathepsin-K, tartrate-resistant acid phosphatase, and the calcitonin receptor, as evaluated by real-time PCR. Phage display was previously used to identify peptides that bind to GPR55. Here, the GPR55-specific peptide-P1 strongly inhibited osteoclast maturation of RAW264.7 macrophages.Conclusions: As bone-metastasis development can be blocked through inhibition of bone resorption, osteoclasts are strong targets for anti-metastatic treatments, and such GPR55-specific peptides might represent useful tools for novel therapeutic approaches.
Socioeconomic Inequalities in Access to Skilled Birth Attendants During Childbirth in Ghana: A Decomposition Analysis
Authors: Kpodotsi Aseye , Baku Elizabeth Aku , Adam Jo Hunter , Alaba Olufunke
Published: September 2020

Background: Equitable access to, and use of skilled birth attendance during delivery is vital for the achievement of the Sustainable Development Goals (SDGs) in reducing global maternal deaths to 70 deaths per 100, 000. Although several initiatives have been implemented to reduce maternal mortality in Ghana, inequities in the use of skilled birth attendance during delivery still exist among women of different socioeconomic groups. This study assessed the socioeconomic inequalities related to the use of skilled birth attendants during delivery in Ghana.Methods: This study analyzed data from the 2014 Ghana Demographic and Health Survey (GDHS). Concentration index (CI) and concentration curves (CC) were employed to measure the magnitude of socioeconomic inequality in the use of skilled birth attendants during child delivery. The concentration index was decomposed to identify the underlying factors driving the inequalities.Results: Out of a total of the 1,305 women who gave birth in the year prior to the interview, 28% of the deliveries had no skilled birth attendants of which 60% lives in rural compared to 40% in urban. A concentration index of 0.147 showed a pro-rich utilization of skilled birth attendance during delivery. The decomposition analysis revealed that wealth, education and location of residence were the major contributors to socioeconomic inequalities in the use of skilled birth attendants during child delivery among Ghanaian women.Conclusion: This study suggests that factors such as wealth, area of residence and education are worthy of increased attention and policy interventions because they are amenable to the reduction of observed inequality.
The Physical and Mental Impact of Surviving Sepsis – A Qualitative Open Interview Study
Authors: Apitzsch Sabine , Larsson Lotta , Larsson Anna-karin , Linder Adam
Published: September 2020

Background: This study aims to illuminate how sepsis survivors experience sepsis and the impact of sepsis as well as the quality of life thereafter. Methods: A qualitative open interview study with eight sepsis survivors was performed. A content analysis inspired by Burnard was made. Results: Four main categories emerged during the analysis; The experience of health care and being a sepsis patient, New circumstances´ impact on life, Family and social interactions, and The psychological impact on life. The lack of information on how sepsis can impact the survivors’ lives and what to expect can lead to prolonged agony. The long recovery time comes as an unexpected and unpleasant surprise to those affected. Initially, the sepsis survivors are almost euphoric that they have survived, which can later lead to chock and trauma when they realize that they could have died. This insight needs to be processed in order to reach reconciliation with how life will turn out after sepsis. Conclusion: Sepsis has a huge impact on both physical and mental aspects of life. Many survivors suffer from persistent residual symptoms of varying degrees to which they have to adapt. The sepsis survivors need individually adjusted information about the sepsis recovery trajectory and what to expect during and after the hospital stay.
Analysis of Chemical Constituents of Guizhi Shaoyao Zhimu Granules by UPLC-Q-Orbitrap HRMS
Authors: Li Tingna , Zeng Hairong , Zhang Xiaorui , Ren Yuanyuan , Zeng Yijia , Gao Yongxiang , huang Qinwan , Tan Jin
Published: September 2020

Background: Guizhi Shaoyao Zhimu Granules (GSZG), which are derived from Guizhi Shaoyao Zhimu decoction in China, have good clinical efficacy in Rheumatoid arthritis(RA) especially. However, there is currently no reliable and systematic method to research the effective ingredients of the kind of prescription. Methods: Vanquish Ultra High Performance Liquid Chromatography Q Exactive IV Pole-electrostatic field orbital trap high resolution mass spectrometer (UPLC-Q-Orbitrap HRMS), a quick and systematic method was established and apply to analysis the chemical component of GSZG. According to using reference standards comparsion, fragmentation rules elucidation and available databases like mzCloud and the OTCML to identify the components of GSZG.Results: The results showed that it identified a total of 74 components, including 2 chromone, 23 flavonoids, 10 alkaloid, 9 phenolic acid, 8 nucleosides and nucleobases, and 22 other components, were characterized from GSZG. Conclusion: this was the first time to systematically report the compounds of GSZG, the chemical basis inquiry of this work would have a profound impact on mechanism exploration and providing certain reference for the preparation and quality control of GSZG developed by China independently.
Super Electrolyte-Philic Boron Nitride Nanotube Membranes as Highly Robust Separators for Lithium Batteries
Authors: Duan Xidong , Shen Xiaohua , Zhu Jian , Zhang Liqiang , Li Bailing , Zhang Hongmei , Wang Lei
Published: September 2020

The widespread deployment of lithium ion (Li+) batteries with increasing energy density entails a worsening safety concern. Among many contributing factors, the typical polymer separators are plagued with poor thermal stability,limited mechanical strength and lower Li+ transference number, and are prone to catastrophic failure when subjected to local thermalor mechanical stress (e.g., pierced by lithium dendrites). Herein, we report an all-inorganicnonwoven boron nitride nanotube membrane featuring exceptional chemical stability, thermal stability, fire resistance and mechanical flexibility. The resulting membranes show superior wettability to electrolyte to endow excellent Li+ transport properties with the lowest ionic resistance and the highest Li+ transference number (0.86) when compared with all commercial separators. They can thus function as highly robust separators for Li/Li symmetriccells with ultralow overpotential (8.5 mV) and exceptional reversibility for repeated lithium plating/stripping cycles for over 8000 hours, and for practical LiFePO4/Li cell with unusually high temperature stability. Our study defines a unique class of super electrolyte-philic ceramic separators with favorable mechanical strength, thermal stability and ion transfer properties for advanced lithium batteries.
Effect of ash existence in the coal particles on the dewatering performance of fine coal
Authors: Zhang Suhong , Gao Ni , Zhao Ke
Published: September 2020

The dewatering experiments of fine coal with different ash contents in the particle size range of 0.125 mm − 0 mm were investigated in this study. Structures of coal samples were characterized by X-ray diffractometer (XRD) and surface functional groups were detected by Fourier transform infrared (FTIR). Wettability and wetting heats of coal samples were determined by contact angle measurements and micro-calorimeter system, respectively. In this study, the dewatering results indicate that the ash content of fine coal had less effect on the coal dewatering than the coalification degree in the dewatering process. However, for the given coal sample the moisture content was significantly affected by the ash content while the coal particle size was less than 0.125 mm. The decrease of moisture content in coal sample after the ash was removed indicating that the hydrophobic property of coal surface was enhanced based on contact angle measurements and wetting heats. In addition, kaolinite played a primary role of minerals in coal for the coal dewatering.
Effect of Particle size on Biomedical Behaviors of Sub-micron Silk Fibroin
Authors: Li Rou , Li Xiao , Peng Ye , Li Dan ni , Cheng Chao , Jia Guo rong , Zuo Chang jing
Published: September 2020

Due to the excellent physicochemical and biomedical properties, silk fibroin (SF) is a good source for the development of biomedical materials, where size selection of SF during biological application heavily affects the related biomedical behaviors. In this research, silk fibroin was step-wisely filtered and classified by syringe filter into four particle sizes ranges (< 200 nm, 200-450 nm, 450-800 nm and > 800 nm), and was then labeled with iodine-125 (125I-SF) for nuclear imaging. Super early (0-40 minutes) and primary (1-72 hours) biodistribution of 125I-SF were evaluated in Wistar rats. SEM-proved spherical or irregular silk fibroin powder with mixed size was not reuniting with each other in aqueous solution. For early in vivo distribution, four SF mostly gathered in the gastrointestinal tract (120-140 times to the background (accumulation in upper limb of left hind leg)), and a small amount (20-40 times) in bladder after injection within 40 min. For SF (< 200 nm, 200-450 nm and 450-800 nm) during the first 72 h, although there was decreasing trend over time, the gastrointestinal accumulation still accounted for the majority. Meanwhile, most of the SF in the bladder was expelled within 1 h and SF could be rarely seen in liver. Notably, SF (> 800 nm) almost gathered in the liver instead of the gastrointestinal tract after 10 h and got the peak value (280 times to the background) at around 48 h. The particle size directly determined the passive distribution of SF in vivo, which can not be ignored during drug design. Above all, these preliminary results may be referable for further biomedical application on silk fibroin.