bluuebunny/crossref_metadata_2025 huggingface dataset:
The Present and Future of Intravesical Therapy in Bladder Cancer
Authors: Seong Sin-Woo , Shin Youngjae , Chang In Ho , Kim Jung Hoon
Published: May 2022

Intravesical therapy is the gold standard in the treatment of nonmuscle invasive bladder cancer (NMIBC). Despite the efficacy of intravesical therapies, the best treatment options are not determined yet. Development in research of bladder cancer shows several new intravesical drugs and its delivery systems. Additionally, the novel knowledge of bladder cancer immune reaction improves and provides ambitious treatment strategies. The future of NMIBC therapy will be changed by the development of immunotherapy and new technologies for device-assisted treatment. This review focuses on recent advances in the intravesical therapy of NMIBC, viral gene therapy, new technology of intravesical chemotherapy, and drug delivery system.
Estimating Measurement Error in University Students’ Work Experience Programme (SWEP) Assessment using Generalizability Theory: Implications for Transdisciplinarity in Engineering Training
Authors: Oladele Jumoke I.
Published: May 2022

Test experts and other stakeholders in education are interested in the quality of students’ assessments, while traditional reliability indices are giving way to Generalisability statistics encouraging transdisciplinarity in problem-solving. This study aimed at estimating measurement error in University Students’ Work Experience Programme (SWEP) assessment using generalizability theory. The design adopted for the study was a one-facet nested fixed design with assessors nested within persons. The study’s target population was all the 200 level undergraduate Engineering students registered for 2015/2016 academic sessions in the Faculty of Engineering in a Nigeria University and all the technicians who assessed them, with 591 students purposively selected. Their assessment scores were collated using a Proforma. Data obtained were analyzed using ANOVA statistics. Findings revealed that the assessor effect confounded the person by assessor interaction. The residual contributed more to measurement error in university engineering SWEP scores; the relative and absolute error variances were equal, with a value of 8.02. Therefore, relative and absolute interpretations cannot be distinguished. Based on these findings, educational researchers engaging in Genralizabilty theory analysis should employ the crossed facets G-study designs in assessment designs to fully harness G-theory’s strength to distinguish between the absolute and relative decisions. This conclusion is so as decision-makers may be interested in one or both decisions while interpreting measurement results in defining error and Generalisability coefficients to employ synergetic efforts to ensure quality engineering education through a transdisciplinary approach to their training.
Accounting Estimation Intensity, Auditor Estimation Expertise, and Managerial Bias
Authors: Boone Jeff P. , Khurana Inder K. , Raman K. K.
Published: May 2022

SYNOPSIS

We examine the relation between the accounting estimation intensity (AEI) ingrained in a company’s financial reports and the company’s propensity to meet or beat analyst earnings forecasts and whether this relation is attenuated by the auditor’s estimation expertise at the city-office or national level. Although we find a positive relation between AEI and the propensity to meet analyst forecasts, we find little evidence to suggest that the relation is weakened by auditor estimation expertise. Along the same lines, we find little evidence to suggest that the positive relation between AEI and audit fees is affected by auditor estimation expertise. Our findings are of potential interest to regulators concerned about insufficient auditor skepticism in the audit of accounting estimates, investors interested in better understanding managerial accounting judgments, and academics investigating audit quality.

JEL Classifications: M41; M42.
Conversations and Reactions Around Severe Hypoglycemia (CRASH) Study: Results From People With Diabetes and Caregivers in the United States
Authors: Snoek Frank J. , Spaepen Erik , Nambu Barbara A. , Child Christopher J. , Bajpai Sanjay , Balantac Zaneta , Bushnell Donald M. , Pokrzywinski Robin , Mitchell Beth D.
Published: May 2022

A survey was conducted in eight countries to examine conversations around, and experiences and treatments during, severe hypoglycemia among people with diabetes and caregivers of people with diabetes. This article reports a subgroup analysis from the United States involving 219 people with diabetes and 210 caregivers. Most respondents (79.7%) did not use professional health care services during their most recent severe hypoglycemic event, and 40.3% did not report the event to their health care providers at a subsequent follow-up visit. Hypoglycemic events left respondents feeling scared (70.9%), unprepared (42.7%), and helpless (46.9%). These clinically important psychosocial impacts on people with diabetes and caregivers underscore the need for conversations about hypoglycemia prevention and management.
Diabetes Care Provider Perceptions Regarding Emerging Adults’ Diabetes Self-Management Influences and Patient-Provider Visit Interactions Within a Safety-Net Hospital
Authors: Wolf Rachel A. , Haw J. Sonya , Martyn Kristy K. , Kimble Laura P.
Published: May 2022

  

The increasing number of emerging adults with diabetes (EAWD) being cared for in adult health care settings requires a better understanding of the needs of EAWD and their interactions with adult health care providers (HCPs). This article describes findings from interviews with endocrinologists and diabetes nurses from a safety-net health care system to investigate HCPs’ perspectives regarding influences on EAWD self-management and HCP interactions with EAWD. HCPs frequently perceived lower EAWD engagement in diabetes management, which was complicated by barriers such as the emotional burden of diabetes, busy lives and multiple responsibilities, and limited access to resources; however, HCPs valued the role of information and communication at visits in tailoring care for EAWD. Measures to tailor care should address the psychosocial burden related to the life stage goals and priorities of EAWD, identification of resources for EAWD and HCPs, and further elucidation of effective self-management guidance and communication strategies to support EAWD in safety-net settings.
MOVE! Enhanced: A Virtual Multidisciplinary Weight and Diabetes Management Program for High-Risk Veterans. A Feasibility Pilot.
Authors: Mendez Carlos E. , Bertram Kristen , Hansen Jill , Taxman Jill , Feest Aaron , Hanley Alfred , Anton Andreaa L.
Published: May 2022

  

The Clement J. Zablocki Veterans Affairs (VA) Medical Center delivers primary, secondary, and tertiary medical care in 166 acute operating beds and provides >600,000 visits annually through an extensive outpatient program. It is the largest VA facility in Wisconsin and, as part of the VA Integrated Services Network 12 (VISN 12), it is designated as a referral base for the upper peninsula of Michigan and northern Illinois. Throughout the state, the medical center has community-based outpatient clinics in Appleton and Green Bay, serving 11 counties in the north central region; Union Grove, serving four counties in the southeastern region, and Cleveland, serving four counties in the east central region. These programs serve a veteran population of ~250,000 (1)
Effect of Tillage and Mulching on Growth, Yield and Economics of Maize Crops
Authors:   Zonal Research Station (Birsa Agricultural University), Chianki, Palamau, Jharkhand (822 102), India, Kumar Pramod , Lata Suman ,   Dept. of Soil Science and Agricultural Chemistry, Bihar Agricultural University, Sabour, Bhagalpur, Bihar (813 210), India, - Swapnil ,   Dept. of Plant Breeding and Genetics, Bihar Agricultural University, Sabour, Bhagalpur, Bihar (813 210), India, Sinha Anuradha ,   Dept. of Horticulture  (Vegetable & Floriculture), Bihar Agricultural University, Sabour, Bhagalpur, Bihar (813 210), India, Singh Digvijay ,   Dept. of Plant Breeding and Genetics, Bihar Agricultural University, Sabour, Bhagalpur, Bihar (813 210), India
Published: May 2022

The field experiments were conducted during July to October, 2017, 2018 and 2019 in split plot design was laid out at Zonal Research Station farm, Chianki, Palamu, Jharkhand, India. The cultural practices included two factors i.e. the first factor included conventional tillage (CT), minimum tillage (MT), raised bed sowing (RBS), the second factor included without mulch (WM), farm waste mulch (FWM), polythene mulch (PM), soil mulch (SM). The rain water use efficiency was higher in raised bed sowing+polythene mulch (5.71 kg ha-1 mm-1) than the other treatments but it was lowest in MT+WM (2.96 kg ha-1 mm-1) over the three years. The high water use efficiency in the year 2019 (5.71 kg ha-1 mm-1) influences the maximum growth and yield (5,169 kg ha-1)of the crop followed by 2018 (4.74 kg ha-1 mm-1) but the minimum yield was found under minimum tillage without mulch in every year. This higher growth leads to higher stover yield and plastic mulch prevents the weeding cost which finally improved the B:C ratio (1.97) by reducing cost of cultivation and improving net return. In conclusion, minimum tillage without mulch is not recommended under dryland condition but raise bed sowing with plastic mulch is a suitable practice among all practices. This shows that raised bed practice prevent the maize crop from excess water condition and plastic mulching is helpful in increasing water use efficiency, controlling weed and maintaining temperature near root zone but no mulch condition degrade the fertile layer of soil by erosion.
Effect of Salting on Mechanical Drying of Pangasius hypophthalmus
Authors:   Dept. of Fish Processing Technology, College of Fishery Science, Sri Venkateswara Veterinary University, Muthukur, Nellore District, Andhra Pradesh (524 344), India, Kumar Gonugodugu Praveen , Xavier K. A. Martin ,   Dept. of Post-Harvest Technology, ICAR-Central Institute of Fisheries Education, Versova, Mumbai, Maharashtra (400 061), India, Nayak Binaya Bhusan ,   Dept. of Post-Harvest Technology, ICAR-Central Institute of Fisheries Education, Versova, Mumbai, Maharashtra (400 061), India, Kumar H. Sanath ,   Dept. of Post-Harvest Technology, ICAR-Central Institute of Fisheries Education, Versova, Mumbai, Maharashtra (400 061), India, Venkateshwarlu Gudipati ,   ICAR-NAARM, Rajendranagar, Hyderabad, Telangana (500 030), India, Balange Amjad K. ,   Dept. of Post-Harvest Technology, ICAR-Central Institute of Fisheries Education, Versova, Mumbai, Maharashtra (400 061), India
Published: May 2022

A study was conducted during 2016 to evaluate the effect of salt and mechanical drying on Pangasius at Central Institute of Fisheries Education, Andheri, Mumbai, India. In this study, the salted and unsalted Pangasius was mechanically dried at 60°C temperature and the quality of the dried Pangasius was evaluated. The quality parameters include the changes in proximate composition, physicochemical parameters [total volatile base nitrogen (TVBN), peroxide value (PV), free fatty acid (FFA), pH, thiobarbituric acid reactive substances (TBARS), salt, water activity], microbial enumeration (total viable count (TVC), Escherichia coli, Staphylococcus spp.) and sensory evaluation. The colour characteristics, percentage yield and storage stability of the product was also evaluated. From the results, it was observed that the protein and ash content of unsalted dried Pangasius was higher than salt dried Pangasius. From the results of physicochemical changes, it was observed that PV, FFA, TVBN, TBARS and salt content were higher in salt dried Pangasius. The TVBN, PV and salt content of salt dried Pangasius were 24.75 mg N 100 g-1, 4.17 meq O2 kg-1 fat and 14.55% respectively which were higher than the Unsaltd dried Pangasius. The salt dried Pangasius had higher L* value but lower a* and b* value than unsalted dried Pangasius. The unsalted dried Pangasius was unstable during storage whereas salt dried Pangasius was stable. Based on the results, it was concluded that salt drying is the most effective method of preservation for drying Pangasius at 60°C.
Studies on preservation of gross pathological cardiac lesions by Thermocol plastination
Authors:   Department of Veterinary Pathology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, India, Syal Priyanka , Singh Charan K. , Gupta Kuldip
Published: May 2022

Demonstration of gross lesions for educational purposes is often based on wet specimens, preserved in formalin, that emit hazardous formaldehyde vapors. This study is a pioneering attempt to plastinate pathological lesions in animal tissues using the economical Thermocol instead of costly resins, viz. silicon, epoxy and polypropylene. Six bovine heart samples, showing pathological lesions, were fixed with 5% formol saline, followed by dehydration in pure acetone, and impregnation with 15% Thermocol in organic solvent. Finally, curing of specimens was undertaken using Touchwood. Three gross lesions of the heart, viz. myocardial cyst, fibrinous pericarditis and endocardial/ epicardial hemorrhages, were plastinated in the present study. The myocardial cyst could be fixed in seven days; the fibrinous pericarditis could be fixed in 10 days, whereas hemorrhages required 15 days for fixation. The heart samples were impregnated by 44-48 days. The color of the lesions became darker and prominent in the plastinated hearts. There was no change in the texture of the tissues due to plastination, whereas the consistency of the heart became harder compared to fresh heart tissue. There was an significant reduction in mean mass (42.95%) and mean volume (40%) in the plastinated specimens. The Thermocol plastinated specimens were non-toxic, dry, easy to handle, odourless and durable, without the disadvantages of traditional formaldehyde preservation.
The effect of ketoprofen on the plasma concentration and pharmacokinetic parameters of ciprofloxacin in chickens
Authors:   Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, Iraq, Mousa Yaareb J. , Amin Sawsan M. , Abdulrazzaq Doaa H. , Ibrahim Fawaz K.
Published: May 2022

Ciprofloxacin (CFX) and ketoprofen (KPN) are used widely in combination in veterinary interventions for bacterial infections, so in this study the effect of KPN was studied on the efficacy of CFX, by measuring its plasma concentration and pharmacokinetic parameters in 7-10 day-old chickens. The analgesic median effective dose (ED50) of KPN was determined to be 1.62 mg/kg, IM, in the chickens. The preferable analgesic dose of KPN to be used with CFX was 4 mg/kg, IM, which differs significantly from KPN 2 mg/kg, IM,. The CFX plasma concentrations alone (8 mg/kg, IM) measured at different times (0.5, 1, 2, 4 and 24 hours) were 3.31, 3.60, 3.21, 2.70 and 0.17 μg/mL while its concentration was elevated by 53, 54, 90, 107 and 418 % when coadministered with KPN (4 mg/kg, IM) to 5.05, 5.53, 6.10, 5.59 and 0.88 μg/mL in the chickens, respectively. CFX pharmacokinetic parameters, such as the area under the curve (AUC), the area under the moment curve (AUMC), mean residence time (MRT), half-life (t1/2β), Tmax, and Cmax increased when KPN was coadministered with CFX by 129, 289, 70, 49, 100 and 69 %, whereas the elimination rate constant (Kel), the volume of distribution at steady state (Vss) and clearance (Cl) decreased by 36, 34 and 58 %, respectively. It was concluded that coadministration of KPN alters the plasma concentration and the pharmacokinetic parameters of CFX, suggesting that the CFX dose can be reduced when used with KPN to achieve the desired concentration of CFX in the plasma, as an antibacterial for treatment of infected animals.
Antimicrobial resistance and virulence traits of Enterococcus faecium isolated from clinical bovine mastitis in Ningxia, China
Authors:   Institute of Animal Science, Ningxia Academy of Agricultural and Forestry Sciences, Yinchuan, Ningxia, China, Li Yuqiong , Gao Haihui , Yu Yang , Zhao Zhengwei , Guo Yanan
Published: May 2022

This study was conducted to determine the antimicrobial resistance and virulence traits of 32 Enterococcus faecium isolates from clinical bovine mastitis cases in Ningxia Province, China. In total, 32 E. faecium isolates were taken from subclinical bovine mastitis on the basis of morphological characterization and biochemical testing, and screened for antimicrobial susceptibility. The virulence genes of the isolates were studied using polymerase chain reaction (PCR). The disc diffusion assay revealed a high occurrence of resistance against tetracycline (78.1%) and erythromycin (68.8%) in the E. faecium isolates. However, all tested E. faecium were susceptible to linezolid and vancomycin. Moreover, all E. faecium isolates harbored the erythromycin-resistant genes ermA, ermB and ermC, as well as the tetracycline-resistant genes tetK, tetL and tetM. Furthermore, all E. faecium isolates carried more than 3 of the tested virulence genes. The presence of agg (100%), cpd (100%), efaA (100%), gelE (93.4%), and esp (75.0%) was found most frequently in all the tested isolates. These findings are useful for making appropriate antimicrobial choices and developing antivirulence therapies for subclinical bovine mastitis caused by E. faecium in Ningxia Province, China.
Housing Demand and Remote Work
Authors:   Federal Reserve Bank of San Francisco, Mondragon John , Wieland Johannes ,   University of California San Diego
Published: May 2022

What explains record U.S. house price growth since late 2019? We show that the shift to remote work explains over one half of the 23.8 percent national house price increase over this period. Using variation in remote work exposure across U.S. metropolitan areas we estimate that an additional percentage point of remote work causes a 0.93 percent increase in house prices after controlling for negative spillovers from migration. This cross-sectional estimate combined with the aggregate shift to remote work implies that remote work raised aggregate U.S. house prices by 15.1 percent. Using a model of remote work and location choice we argue that this estimate is a lower bound on the aggregate effect. Our results imply a fundamentals-based explanation for the recent increases in housing costs over speculation or financial factors, and that the evolution of remote work is likely to have large effects on the future path of house prices and inflation.
The Impact of Artificial Intelligence on Human Resources Management Strategy: Opportunities for the Humanisation and Risks
Authors: KONOVALOVA Valeriya , MITROFANOVA Elena , MITROFANOVA Alexandra , GEVORGYAN Rita
Published: May 2022

The article discusses the growing role of artificial intelligence in human resources management strategy. The results of research and practical experience confirm the possibility of using artificial intelligence to humanise human resource management (reducing bias in the selection of personnel, mastering employees’ experience, personalising training, analysing the emotional state of employees, and managing their wellbeing) are generalised. Highlighted are the risks of dehumanisation of personnel management when introducing artificial intelligence, which can be caused by both new threats and the strengthening of existing problems in this area.
Business Philosophy: Modern Trends and Digital Solutions
Authors: BAURINA, Svetlana , PASHKOVSKAYA Margatita , NAZAROVA Elena
Published: May 2022

This article focuses on the modern vision of business philosophy. The authors of the article correctly substantiated the significance and extreme need to use philosophical knowledge and thinking both during the initiation and implementation of entrepreneurial ideas and during the practical implementation of entrepreneurial activity and direct business. Modern realities give the businessman the opportunity for independent choice, and a professional approach in business conduct is essential. The philosophical thinking of the entrepreneur, according to the authors, is the way to efficient business. Mastering the philosophy of business and the practical use of its provisions will ensure sustainable long-term success in the entrepreneurial environment. The realities of pervasive digitalization can fill with new semantic content modern processes in business with the parallel natural development of morality and culture. The new digital ecosystem is designed to combine the brilliant potential of the machine with an unsurpassed human mind to introduce technological innovations in business structures at the most favourable level.
Editorial
Authors: Sykes Olivier
Published: May 2022

This issue (5.2) of Transactions of AESOP brings together a selection of papers which address current themes and issues in planning education. Two of the papers reflect on the experience of teaching modules submitted to recent rounds of the AESOP Excellence in Teaching Award (ETA), one reports on an experience of internationalisation in planning education, and one is an invited paper by Andrea Frank the present Chair of the AESOP ETA Committee. They all provide original and insightful contributions addressing key themes in contemporary planning education including, the impacts of the COVID-19 pandemic, new technologies and modes of teaching delivery, the teaching of landscape in planning programmes, and, the internationalisation of planning cohorts and curricula.
A Pharmacist-Driven Education and Intervention Program that Improves Outcomes for Hypertensive Patients
Authors: Zagel Alicia , Rhodes Adam , Nowak Jeri , Brummel Amanda
Published: May 2022

Purpose: Uncontrolled hypertension is serious and may lead to severe cardiovascular events and death. To better educate and empower patients to meet their blood pressure (BP) management goals, a large, integrated academic healthcare system implemented the Blood Pressure Goals Achievement Program (BPGAP), a longitudinal intervention embedding community pharmacists within healthcare teams. This study evaluated BPGAP on its ability to promote patient BP management goals.
Methods: A pre-/post-intervention analysis was conducted whereby BP measurements were evaluated longitudinally within acuity groups determined by k-means clustering. Generalized linear mixed models evaluated trends in BP by time period, and proportions of patients meeting BP management goals (<140/90 mmHg) were assessed in relation to BPGAP enrollment date.
Results: There were 5,125 patients who were clustered into Uncontrolled, Borderline, and Controlled blood pressure groups; 2,108 patients had BP measurements across 4 time periods before and after BPGAP enrollment. Groups differed by patient age, sex, and other demographics (p<0.0001). Patients in the Uncontrolled and Borderline BP clusters demonstrated significant BP decreases after BPGAP enrollment, continuing at least to 1-year post-intervention; Controlled cluster patients maintained BPs throughout the study period. The proportion of patients with controlled BPs increased from 56% immediately pre-BPGAP to 74% in the 3- to 6-months following enrollment.
Conclusion: BPGAP is effective at helping patients achieve their BP management goals. Pharmacists may play a key role in hypertension control through measuring BPs and including updates and recommendations in the electronic health record, educating patients, and engaging in communication with healthcare teams.
Quebranto del sistema jurídico mexicano en el seguro de riesgos de trabajo
Authors: Martínez Martínez Verónica Lidia
Published: May 2022

El artículo tiene como objetivo analizar el esquema de protección del seguro de riesgos de trabajo y las contradicciones y omisiones que imperan en él mismo en detrimento de los derechohabientes y los empleadores. Para lograr lo anterior, en primer lugar, a partir de la conceptualización y las principales características de los riesgos de trabajo, se realiza un estudio de las prestaciones que debieran otorgarse al asegurado y a sus beneficiarios con los recursos que aportan los patrones en cumplimiento a la fracción XIV del artículo 123 constitucional, en su apartado A en correlación con el artículo 70 de la Ley del Seguro Social como forma de reparar el daño sufrido al suscitarse las consecuencias que derivan de los riesgos de trabajo. En segundo lugar, un tema fundamental que se aborda en esta obra, es el análisis de la anticonstitucionalidad, la inconvencionalidad y las omisiones que imperan en el seguro de riesgos de trabajo en contravención a los derechos patrimoniales y de seguridad de los asegurados inscritos en el régimen obligatorio del seguro social, además de traer aparejado el desvío de los recursos de la cuenta individual para financiar las prestaciones del seguro de riesgos de trabajo.
AGE DYNAMICS OF PHYSIOLOGICAL AND BIOMECHANICAL COMPONENTS OF THE FORMATION OF STATODYNAMIC AND POSTURAL FUNCTION IN CHILDREN OF THE SECOND PERIOD OF CHILDHOOD
Authors:   Khanty-Mansiysk State Medical Academy, Kozlovsky Ilya Vyacheslavovich , Koinosov Andrei Petrovich
Published: May 2022

Maintaining the balance of the human body in an upright position is ensured by the functional usefulness of the vestibular, visual, proprioceptive systems and the musculoskeletal system. The control is carried out by the structures of the central nervous system, and all the mentioned systems can be combined by the concept of “a system for providing stat dynamic control”. The article highlights the view of various researchers on the mechanisms of adaptation of the stat dynamic function and postural balance of the body of children of the second period of childhood to natural physical exertion, as well as the correlation of some age-related anthropometric indicators with functional ones, which allows us to more fully characterize and understand the features of the functioning and interaction of systems that provide stat dynamic control in a person at a certain stage of his development. A review of the literature data allowed us to summarize some available information about the features of such indicators as the development of the supporting function of the foot, the balance function in a certain age category of people in normal and pathological conditions. The main purpose of the review was largely to identify the value indicators characterizing the functional physiological state of the balance of the lower extremities and balance in an individual in order to take them as criteria for evaluating the conditional norm. An attempt is made to assess the integrity of the found indicators, the need for their refi nement and combination with other indicators, since often the functional indicators of the assessment of postural function were evaluated by the authors in isolation from the structural ones and vice versa. It was also necessary to form a primary idea of the infl uence of external factors on the desired evaluation criteria. One of the tasks was to fi nd diff erences, or their absence, in the functional indicators of the balance of the lower extremities and the balance function in children, depending on age variations within the group and gender diff erences, and to conduct a certain analysis to understand from what age these indicators can be considered identical to similar indicators in adults. An important task was to consider some of the options described in scientifi c research for infl uencing the physiological and biomechanical processes of ensuring the stat dynamic and postural functions of the body.
MEDICAL ASSISTANCE TO STROKE PATIENTS IN THE REGIONAL VASCULAR CENTER OF KHANTY-MANSIYSK
Authors:   Khanty-Mansiysk State Medical Academy, Anishchenko Lyudmila Ivanovna , Molchanova Zhanna Ivanovna , Sokolova Azaliya Aisarovna , Tupilenko Oksana Petrovna , Shсhedukhina Elena Viktorovna , Romanovskaia Natalia Sergeevna , Rapgof Aleksandr Aleksandrovich , Pavlyukova Alena Aleksandrovna
Published: May 2022

The case histories of 692 stroke patients hospitalized in the regional vascular center of the KhantyMansiysk Regional Clinical Hospital for the period from 2019–2021 were analyzed in order to assess the epidemiological characteristics, clinical aspects of the course to assess the eff ectiveness of specialized medical care for these patients and optimize the stroke prevention program. The number of stroke patients treated at the regional vascular center decreased by 25.4% in 2020 and increased by 31.6% in 2021. in connection with the COVID-19 pandemic. There was also an increase in the number of recurrent ischemic strokes in 2021 by 29.4% compared to 2020, which may indicate insuffi cient prevention of recurrent stroke during the COVID-19 pandemic. In total, 45.4% of patients were admitted in the fi rst 6 hours after the onset of stroke symptoms, so it is necessary to raise public awareness through social advertising to prevent late access to medical care for stroke patients
PROBLEM ISSUES OF MINERAL METABOLISM IN RESIDENTS OF THE ARCTIC TERRITORIES
Authors:   North-Eastern state University, Gorbachev Anatoly Leonidovich
Published: May 2022

Biogeochemical characteristics of the regions of the North are given on the basis of literature and own data. Poor knowledge of the microelement status of the inhabitants of the northern regions is shown. Data on technogenic pollution of the biosphere of the northern regions with heavy metals are given. Emphasis is placed on the accumulation of mercury in the biosphere, which has a neurotoxic eff ect. The reason for the deviation of the physiological and biochemical parameters of a person in the conditions of the modern North against the background of environmental pollution is a violation of the structure and quality of nutrition. It was concluded that in order to preserve the health of migrants and indigenous people, it is necessary to carry out geochemical zoning of modern Arctic regions, identify the “predisposition” of individual territories to biogeochemical endemias, and also carry out preventive measures to protect the population from environmentally dependent diseases.
SECURITY OF DIETARY DIETS WITH ASCORBIC ACID FOR YOUNG WOMEN IN THE ARCTIC AND SURRARCTIC ZONES OF THE RUSSIAN FEDERATION
Authors:   Khanty-Mansiysk State Medical Academy, Lapenko Vladislav Vladislavovich , , Korchina Tatyana Yakovlevna
Published: May 2022

In 137 women (18–44 years old) living for more than 5 years in Salekhard (YaNAO, n = 62) and KhantyMansiysk (KhMAO, n = 75), using the ASPON-nutrition program, we studied the intake of vitamin C with daily rations within 3 days. The results obtained were compared with the physiological need (FP) according to MR 2.3.1.0253-21. A defi ciency of vitamin C consumption was established in both groups of examined persons: 1.5 and 1.7 times lower than the FP, respectively, in Khanty-Mansiysk and Salekhard.
ANALISIS POTENSI PENYEBAB KERUSAKAN TONGKAT KEMUDI KAPAL SABUK NUSANTARA
Authors: Abubakar Andi Ahmad Zafwan
Published: May 2022

Kapal Sabuk Nusantara jenis Kapal Perintis yang merupakan kapal pengangkut barang dan penumpang yang diklaskan menurut BKI ini mengalami masalah pada sistem kemudinya terutama pada bagian tongkat kemudi beberapa kapal ditemukan mengalami kerusakan bahkan terlepas dan hilang dari porosnya selama proses pelayarannya sehingga perlu dianalisis. Metode analisis yang digunakan adalah simulasi kuantitatif untuk mendeskripsikan perbandingan kekuatan struktur, material dan analisis kekuatan, cacat produksi serta beban insidentil yang terjadi pada tongkat kemudi kapal Perintis Sabuk Nusantara di mana proses identifikasi masalah menggunakan Fishbone Diagram. Hasil yang didapat kerusakan tongkat kemudi terjadi dikarenakan beberapa potensi kerusakan pada tongkat kemudi seperti material tidak standar, temuan cacat pada material karena kegagalan produksi dan beban insidentil berupa kapal kandas, hantaman kayu serta terlilit tali pada saat proses mooring rope
Traditional Martial Arts and Shooting Training Have Different Effects on Auditory Fine Structure Processing Ability - Evidence from Behavioral Tests and fMRI
Authors: Ding Yu , Zhang Keying , Li Liang , Cao Chunmei
Published: May 2022

In this work, we explore the influence of traditional martial arts and shooting training on the ability of auditory Temporal Fine Structure (TFS) processing. Twenty-five college students participated in the experiment, including 8 traditional martial arts practitioners, 8 high-level shooting athletes, and 9 control groups without any regular exercise habits. The BIC (break in interaural correlation) delay threshold and TFS1 test were used to evaluate the transient storage capacity and sensitivity of TFS, respectively. An fMRI test was performed after the behavioral tests. The results found that the traditional martial arts group had stronger TFS sensitivity, while the shooting group had stronger TFS storage capacity and the performance of the behavioral tests of the shooting group is related to the fALFF value of the brain areas of interest. The effects of exercise training on hearing ability may have a specific neural basis and can be used for early intervention in potential hearing impairment.
DIFFICULTIES IN TEACHING CHINESE TO HUMANITIES STUDENTS IN RUSSIAN UNIVERSITIES AND METHODS TO OVERCOME THEM
Authors:   Institute of Foreign Languages, Peoples’ Friendship University of Russia (Moscow, Russia), Anran Yi
Published: May 2022

tatement of the problem. The importance of studying the difficulties of teaching Chinese to students of the humanities in Russian universities is due to the current international situation and the need to improve the system of training humanities graduates in accordance with the requirements of the time. The purpose of the article is to study modern ideas about the difficulties of teaching Chinese to students studying in Russian universities in the Humanities. Methodology (materials and methods). In the course of the study, the author used such methods as study, systematization, as well as analysis of special literature, observation, description, analysis of teaching experience. Materials: scientific publications concerning the problems and features of teaching Chinese to humanities students in Russian universities. Research results, conclusions, author’s contribution. Difficulties in teaching Chinese are revealed. This is associated with the lack of a unified international terminology, an insufficient number of hours allocated for the study of a foreign language. The author formulates a list of recommendations aimed at eliminating the existing difficulties.
FORMATION OF ENVIRONMENT FOR PROFESSIONAL SELF-DETERMINATION OF STUDENTS FROM INDUSTRY-SPECIFIC “EMERCOM-RESOURCE” CLASS IN THE SCHOOL COMPLEX
Authors:   KSPU named after V.P. Astafyev, Bushlanova Yu.S. ,   the Secondary School Nо. 148 named after the USSR Hero I.A. Borisevich (Krasnoyarsk, Russia)
Published: May 2022

Statement of the problem. In the conditions of modern education in the Russian Federation, one of the most important tasks facing educational organizations is the creation of optimal conditions for professional self-determination of an individual. The FSES SGE emphasizes the importance of the personal results that form its basis. At the same time, one of the conditions for the formation of professional self-determination is the environment of professional self-determination. The purpose of the article is to determine the content of the work on the formation of the environment for professional self-determination of high school students studying in the industry-specific “EMERCOM-resource” class in the school complex. Materials and methods. In the course of the research, the analysis of scientific literature and pedagogical experience was carried out to determine the content of work on the formation of the environment for professional self-determination of high school students studying in the industry-specific “EMERCOM-resource” class in the school complex. The experimental base of the study was the MAEI “Secondary School No. 148 named after Hero of the Soviet Union I.A. Borisevich” in Krasnoyarsk. Research results. The formation of the environment for professional self-determination is closely related to the implementation of an individual educational route, which includes an individual curriculum of a high school student, an individual project, an individual plan of extracurricular activities, additional education, and vocational training. The key tool of the professional self-determination environment is the digital educational and methodological complex “School skills. Pro-professions”. Conclusion. The school complex uses technological solutions for the formation of the environment of professional self-determination based on the personification of the content of education, the introduction of modern educational technologies, the integration of basic and additional education in terms of achieving the planned educational results, accompanying individual educational routes of high school students with subsequent consolidation of their implementation in the basic educational programme.
MARKERS OF ROOTEDNESS IN THE SPEECH OF RESIDENTS OF SETTLEMENTS ALONG THE YENISEI RIVER
Authors:   Reshetnev Siberian State University of Science and Technology (Krasnoyarsk), Mikhaylov A.V.
Published: May 2022

The study of the current state of self-perception of the inhabitants of rural settlements of Yenisei Siberia should be based on the previous experience of studying the “colonization” (development) of Siberia in its various forms. The paper considers the parameters of «rootedness» (stability) as a semantic complex opposed to “mobility”. The material was the speech of Russian-speaking residents of settlements along the Yenisei River, as well as residents of settlements on the Taimyr Peninsula of the Krasnoyarsk Territory. The author observes that informants emphasize a stable state at the actual observed time. To indicate the “rootedness”, informants use lexemes with the semantics of being in place, origin from a worthy ancestor, economic or other necessity of previous relocations, toponyms indicating the development of the territory. The author comes to conclusions about the importance demonstrated to the collector for the informant as a functional manager of the locality of the status of permanent residence and full possession of his own territory of the settlement as a whole and its surroundings.
EVALUATIVE SEMANTICS OF THE METAPHORICAL MODELS “MAN IS A MECHANISM” AND “MECHANISM IS A MAN” IN THE RUSSIAN LANGUAGE PICTURE OF THE WORLD
Authors:   Siberian State Medical University  (Tomsk, Russia), Abramova A.A. , Vasilyeva V.L. ,   Siberian State Medical University (Tomsk, Russia), Volkova M.G. ,   Siberian State Medical University (Tomsk, Russia)
Published: May 2022

Statement of the problem. This article analyzes the anthropomorphic image of a mechanism and the mechanistic image of a person in the aspect of evaluative semantics, reveals the axiological orientation of conceptual models, and presents the characteristics of the reversible correlation of the analyzed concepts in terms of their evaluative orientation. The purpose of the article is to analyze the metaphorical models “MAN – MECHANISM” and “MECHANISM – MAN” in terms of evaluative semantics, to identify the nature and axiological potential of conceptual metaphorical models. The study was carried out on the methodological basis of cognitive linguistics and was carried out on the material of the texts of the National Corpus of the Russian Language, Internet forums representing the semantics of the mechanism both as a target sphere and as a source sphere for the metaphorical interpretation of the image of a person. Research results confirm the functional-semantic asymmetry of metaphorical models, which appears in different evaluative orientations of the metaphors of the compared models. Thus, most of the lexical representatives of the “MAN is a MECHANISM” model is characterized by a negative evaluative connotation: a person in the image of a mechanism is characterized negatively or ironically. While the evaluative semantics of the metaphors of the correlated MM “MECHANISM is a MAN” is characterized by neutrality.
POLITICAL ACTUALIZATION OF TEMPORALITY AS A SUBJECTIVE COMPONENT OF THE LINGUISTIC IMAGE OF A FEMALE POLITICIAN
Authors:   Siberian  Federal University (Krasnoyarsk, Russia), Boguslavskaya O.V.
Published: May 2022

Statement of the problem. This research work is focused on the analysis of the linguistic image of a female communicative type of politician, which has become one of the most attractive objects of study in recent decades. The term “linguistic image” is quite universal. The interest of modern linguistic science in the subject is explained not only by the leading anthropocentric paradigm, but also by the global process of human activities mediatization. The purpose of the article is to reconstruct the subjective component of the linguistic image of a female politician in the context of temporal actualization. Review of scientific literature on the problem. The wide range of works on the linguistic personality in general and the communicative component in particular reveals that the scope of researches related to the study of the time actualization component in the context of the modus categories of the female communicative type politician image is not sufficiently represented. The methodology (materials and methods). The research work is based on the texts of public speeches by Maria Zakharova, a representative of the Ministry of Foreign Affairs, for the period of 2016-2018. The methods of linguistic description (descriptive-analytical method), relative-comparative method, as well as the method of semantic analysis are used in the work. Research results. The semantic analysis of the texts of M. Zakharova’s public speeches revealed that one of the modus markers of the speaker’s public language images is the actualization of the temporality of a political event. It is interesting that for M.Zakharova the actual time periods in the structure of the traditional three-part time model are present and future time models. Conclusion. The analysis of the modus meanings of M. Zakharova’s public texts showed that one of the temporal fields is the field of the present tense. It seems logical since the subject of the power sphere identifies with the situation of speaking at present and the powers he or she is actively executing at the moment. However, it is interesting that M. Zakharova chooses futural forms as the second temporal component in the temporal speech paradigm. In this form the speaker appears in the speech position of the “forecaster” as she acts as the authority responsible for the political present and future.
SHAMELESS CHARM OF ANGLICISMS: MAGNETISM OF OBSCURE WORDS
Authors:   Krasnoyarsk State Pedagogical University named after V.P. Astafyev (Krasnoyarsk, Russia), Vasilyev A.D.
Published: May 2022

Statement of the problem. Problems related to lexical borrowings invariably arouse the interest of linguists. Probably, both the possible reasons for borrowing and their socio-cultural consequences are particularly attractive for studying. Therefore, it is urgent to study the factors contributing to the readiness of the language community to unconditionally accept borrowings from the Anglo-American and their active use. The purpose of the article is a socio-cultural analysis of borrowings, their semantic and pragmatic status in the Russian language. To achieve the goal, discursive, linguoculturological and semantic methods of analysis were used. Research results. One of the catalysts of the above-mentioned turbulent process is the impenetrability of the internal form of a foreign word for most native speakers of the Russian language. Such lexemes often become the germs of new myths channeled through the media and used to manipulate public consciousness. Conclusions. Today’s features of the borrowing process speak of their proximity to traditional verbal magic. Public speech of representatives of the Russian ruling stratum act as a serious impulse encouraging the use of Anglicisms instead of semantically adequate Russian words.
ASSESSMENT OF THE INFLUENCE OF VEHICLE PARAMETERS ON THE VALUE OF THE SATURATION FLOW
Authors:   Belgorod State Technological University named after V. G. Shukhov, Belgorod, Russia, Shevtsova A. G. , Burlutskaya A. G. ,   Belgorod State Technological University named after V. G. Shukhov, Belgorod, Russia, Jung A. A. ,   Belgorod State Technological University named after V. G. Shukhov, Belgorod, Russia
Published: May 2022

Abstract. As a result of the changes that the car market has undergone over the past decades, a large number of various cars have appeared on the road, which are excellent primarily in design characteristics (length, width, height, weight, etc.), as well as dynamic (power, braking time, turning radius, etc.). When they are taken into account as the characteristics of a conventional car, incorporated into the initial model for calculating the parameters of a controlled intersection, it is possible to obtain variable data that will affect the final result — the value of the saturation flow. In order to determine the variability of the saturation flow values, taking into account certain parameters of a conventional car, the study presented in this article was carried out. The main objectives of the study were to analyze the composition of the traffic flow; determining the design and dynamic characteristics of the most common vehicles in the stream; establishing the parameters of a conditional car, determined by the calibrated one and calculating the saturation flux with subsequent comparison of the data obtained. When carrying out the research, the methods of field observations, analysis and mathematical calculation were used. The calculations were performed using a mathematical model used to determine the value of saturation flux when performing a turn, depending on the turning radius. In the study, this model was determined as the main one due to the fact that on many sections of the road network the turning radii change significantly, in contrast to the basic model, which depends on the lane width, which in most cases is standardized or does not change as much as turning radii. Based on the results of calculations, the variability of the ST values was obtained at 7% for the minimum value of the turning radius and 20% for the maximum value, which requires further research to assess the influence of the obtained results on the calculated parameters of the traffic light operation — the duration of the main ticks and the duration of the entire cycle, as well as on the parameters the transport stream itself when establishing new, refined work cycles.