bluuebunny/crossref_metadata_2025 huggingface dataset:
Making a U-turn on the Purfleet Interchange: Stone Tool Technology in Marine Isotope Stage 9 Britain and the Emergence of the Middle Palaeolithic in Europe
Authors: White Mark , Rawlinson Aaron , Foulds Freddie , Dale Luke , Davis Rob , Bridgland David , Shipton Ceri , Ashton Nick
Published: May 2024

This paper re-examines earlier Palaeolithic core technology from British sites assigned to MIS 11, 9, and 7 using primarily a châine opératoire approach, with the objective of better understanding the earliest occurrence and distribution of Levallois and other prepared-core technologies across the Old World. Contrary to previous interpretations (White and Ashton in Current Anthropology, 44: 598–609, 2003), we find no evidence for a true Levallois concept in MIS 11 or MIS 9 in Britain. Cores previously described as ‘simple prepared cores’ or ‘proto-Levallois’ cores show neither evidence of core management nor predetermination of the resulting flakes. They can instead be explained as the coincidental result of a simpler technological scheme aimed at exploiting the largest surface area of a core, thereby maximising the size of the flakes produced from it. This may be a more widespread practice, or a local solution derived from existing principles. Levallois appears fully formed in Britain during terminal MIS 8/initial MIS 7. Consequently, Britain does not provide evidence for an in situ evolution of Levallois, rather we argue it was introduced by new settlers after a glacial abandonment: the solution to the emergence and significance of Levallois lies in southern Europe, the Levant and Africa.
Average Degree of the Essential Variety
Authors: Breiding Paul , Fairchild Samantha , Santarsiero Pierpaola , Shehu Elima
Published: May 2024

The essential variety is an algebraic subvariety of dimension 5 in real projective space $$\mathbb R\mathrm P^{8}$$

R

P
8

which encodes the relative pose of two calibrated pinhole cameras. The 5-point algorithm in computer vision computes the real points in the intersection of the essential variety with a linear space of codimension 5. The degree of the essential variety is 10, so this intersection consists of 10 complex points in general. We compute the expected number of real intersection points when the linear space is random. We focus on two probability distributions for linear spaces. The first distribution is invariant under the action of the orthogonal group $$\textrm{O}(9)$$

O
(
9
)

acting on linear spaces in $$\mathbb R\mathrm P^{8}$$

R

P
8

. In this case, the expected number of real intersection points is equal to 4. The second distribution is motivated from computer vision and is defined by choosing 5 point correspondences in the image planes $$\mathbb R\mathrm P^2\times \mathbb R\mathrm P^2$$

R

P
2

×
R

P
2

uniformly at random. A Monte Carlo computation suggests that with high probability the expected value lies in the interval $$(3.95 - 0.05,\ 3.95 + 0.05)$$

(
3.95
-
0.05
,

3.95
+
0.05
)

.
MicroRNA (miRNA) profiling of maize genotypes with differential response to Aspergillus flavus implies zma-miR156–squamosa promoter binding protein (SBP) and zma-miR398/zma-miR394–F -box combinations involved in resistance mechanisms
Authors: Gandham Prasad , Rajasekaran Kanniah , Sickler Christine , Mohan Harikrishnan , Gilbert Matthew , Baisakh Niranjan
Published: May 2024

Maize (Zea mays), a major food crop worldwide, is susceptible to infection by the saprophytic fungusAspergillus flavusthat can produce the carcinogenic metabolite aflatoxin (AF) especially under climate change induced abiotic stressors that favor mold growth. Several studies have used “-omics” approaches to identify genetic elements with potential roles in AF resistance, but there is a lack of research identifying the involvement of small RNAs such as microRNAs (miRNAs) in maize-A. flavusinteraction. In this study, we compared the miRNA profiles of three maize lines (resistant TZAR102, moderately resistant MI82, and susceptible Va35) at 8 h, 3 d, and 7 d afterA. flavusinfection to investigate possible regulatory antifungal role of miRNAs. A total of 316 miRNAs (275 known and 41 putative novel) belonging to 115 miRNA families were identified in response to the fungal infection across all three maize lines. Eighty-two unique miRNAs were significantly differentially expressed with 39 miRNAs exhibiting temporal differential regulation irrespective of the maize genotype, which targeted 544 genes (mRNAs) involved in diverse molecular functions. The two most notable biological processes involved in plant immunity, namely cellular responses to oxidative stress (GO:00345990) and reactive oxygen species (GO:0034614) were significantly enriched in the resistant line TZAR102. Coexpression network analysis identified 34 hubs of miRNA-mRNA pairs where nine hubs had a node in the module connected to their target gene with potentially important roles in resistance/susceptible response of maize toA. flavus.The miRNA hubs in resistance modules (TZAR102 and MI82) were mostly connected to transcription factors and protein kinases. Specifically, the module of miRNA zma-miR156b-nb – squamosa promoter binding protein (SBP), zma-miR398a-3p – SKIP5, and zma-miR394a-5p – F-box protein 6 combinations in the resistance-associated modules were considered important candidates for future functional studies.
Ancient South America
Authors: Bruhns Karen Olsen
Published: May 2024

Ancient South America, 2nd edition features the full panorama of the South American past from the first inhabitants to the European invasions  Isolated for all of prehistory and much of history, the continent witnessed the rise of cultures and advanced civilizations rivalling those of Europe, Asia, and Africa. Independently of developments elsewhere, South American peoples invented agriculture, domesticated animals, and created pottery, elaborate architecture, and the arts of working metals. Tribes, chiefdoms, and immense conquest states rose, flourished, and disappeared, leaving only their ruined monuments and broken artifacts as testimonials to past greatness. This new edition is completely revised and updated to reflect archaeological discoveries and insights made in the past three decades. Incorporating new findings on northern and eastern lowlands, and discussions of the first civilizations, it also examines the first inhabitants of Brazil and Patagonia as well as the Andes. Accessibly written and abundantly illustration, the volume also includes chronological charts and new examples.
The Czech Legend of St Catherine of Alexandria
Authors: Thomas Alfred
Published: May 2024

The first complete translation of a fascinating piece of Czech literature.
Limit pretrees for free group automorphisms: existence
Authors: Mutanguha Jean Pierre
Published: May 2024

To any free group automorphism, we associate a real pretree with several nice properties. First, it has a rigid/non-nesting action of the free group with trivial arc stabilizers. Secondly, there is an expanding pretree-automorphism of the real pretree that represents the free group automorphism. Finally and crucially, the loxodromic elements are exactly those whose (conjugacy class) length grows exponentially under iteration of the automorphism; thus, the action on the real pretree is able to detect the growth type of an element.

This construction extends the theory of metric trees that has been used to study free group automorphisms. The new idea is that one can equivariantly blow up an isometric action on a real tree with respect to other real trees and get a rigid action on a treelike structure known as a real pretree. Topology plays no role in this construction as all the work is done in the language of pretrees (intervals).
Relationships between two linearizations of the box-ball system: Kerov–Kirillov–Reschetikhin bijection and slot configuration
Authors: Mucciconi Matteo , Sasada Makiko , Sasamoto Tomohiro , Suda Hayate
Published: May 2024

The box-ball system (BBS), which was introduced by Takahashi and Satsuma in 1990, is a soliton cellular automaton. Its dynamics can be linearized by a few methods, among which the best known is the Kerov–Kirillov–Reschetikhin (KKR) bijection using rigged partitions. Recently, a new linearization method in terms of ‘slot configurations’ was introduced by Ferrari–Nguyen–Rolla–Wang, but its relations to existing ones have not been clarified. In this paper, we investigate this issue and clarify the relation between the two linearizations. For this, we introduce a novel way of describing the BBS dynamics using a carrier with seat numbers. We show that the seat number configuration also linearizes the BBS and reveals explicit relations between the KKR bijection and the slot configuration. In addition, by using these explicit relations, we also show that even in case of finite carrier capacity the BBS can be linearized via the slot configuration.
Deformations of Calabi–Yau varieties withk-liminal singularities
Authors: Friedman Robert , Laza Radu
Published: May 2024

The goal of this paper is to describe certain nonlinear topological obstructions for the existence of first-order smoothings of mildly singular Calabi–Yau varieties of dimension at least$4$. For nodal Calabi–Yau threefolds, a necessary and sufficient linear topological condition for the existence of a first-order smoothing was first given in [Fri86]. Subsequently, Rollenske–Thomas [RT09] generalized this picture to nodal Calabi–Yau varieties of odd dimension by finding a necessary nonlinear topological condition for the existence of a first-order smoothing. In a complementary direction, in [FL22a], the linear necessary and sufficient conditions of [Fri86] were extended to Calabi–Yau varieties in every dimension with$1$-liminal singularities (which are exactly the ordinary double points in dimension$3$but not in higher dimensions). In this paper, we give a common formulation of all of these previous results by establishing analogues of the nonlinear topological conditions of [RT09] for Calabi–Yau varieties with weighted homogeneousk-liminal hypersurface singularities, a broad class of singularities that includes ordinary double points in odd dimensions.
Facies characterisation and stratigraphy of the upper Maastrichtian to lower Danian Maastricht Formation, South Limburg, the Netherlands
Authors: Kroth Mateus , Trabucho-Alexandre João P. , Pimenta Mariana Pinheiro , Vis Geert-Jan , De Boever Eva
Published: May 2024

The Maastricht Formation is a mostly calcarenitic unit that belongs to the Chalk Group but is unlike the typical North Sea chalk in that it is much coarser and at times contains a significant terrigenous component. The formation was deposited between the late Maastrichtian and the early Danian in a proximal zone of the Chalk Sea immediately north of the Anglo-Brabant and Rhenish massifs. The formation crops out in South Limburg, the Netherlands, in the German state of North Rhine–Westphalia, near Aix-la-Chapelle (Aachen), and in the Belgian provinces of Liège and Limburg, and it is present in the subsurface in the Campine Basin and in the Roer Valley Graben, in Belgium and the Netherlands.

The often spectacular fossil content of the Maastricht Formation has been extensively studied but its sedimentological aspects remain understudied. Indeed, the lithostratigraphy of the formation is largely informal and based on the abundance and morphology of flint and on the quantification of fossil content. The paucity of facies studies and the lack of a lithostratigraphic framework based on modern facies studies hampers stratigraphic correlation between outcrops and, more importantly, boreholes. A facies characterisation and facies-based lithostratigraphic framework of the Maastricht Formation in South Limburg is particularly urgent because groundwater is abstracted from aquifers in the formation and geological models currently in place fail to predict facies heterogeneity and, consequently, aquifer properties.

We studied eight outcrops of the Maastricht Formation across South Limburg and carried out a (micro)facies analysis of the outcrops. We show that the Maastricht Formation can be subdivided into three lithofacies and five microfacies. The lithofacies reflect the traditional subdivision of the formation into Maastricht and Kunrade limestones. Our results suggest that the current subdivision of the Maastricht Formation into six members is untenable. The formation is best subdivided into lower and upper members. The Kunrade limestone should be afforded the status of formation.

We interpret the Maastricht Formation as having been deposited in an epeiric ramp, in which facies distribution was controlled by water temperature, nutrient levels and storminess. The (micro)facies of the Maastricht Formation can be organised into two depositional stages: stage 1, representing the lower part of the formation, is characterised by heterozoan carbonates deposited under cooler, mesotrophic conditions in a nutrient-rich, more proximal region of the epeiric sea; stage 2 is characterised by heterozoan-photozoan carbonates deposited in a warmer and stormier environment with slightly lower nutrient levels.
First record of the phyllosoma larva of the pygmy locust lobster Scyllarus pygmaeus (Crustacea, Decapoda) in the eastern Mediterranean sea
Authors: Guy-Haim Tamar , Iakovleva Anastasiia , Ermak Khristina , Spanier Ehud , Morov Arseniy R.
Published: May 2024

Taxonomic intricacies and high interspecific similarity have hampered the identification of scyllarid phyllosoma larvae to the species level. The pygmy locust lobster, Scyllarus pygmaeus, is distributed across the Mediterranean Sea and in the eastern Atlantic; however, its phyllosoma larvae were previously recorded only from the western Mediterranean. We employed DNA barcoding using the mitochondrial COI gene to identify S. pygmaeus phyllosoma collected from the offshore waters of the southeastern Mediterranean Sea and described its morphology. We further discuss the lack of genetic structure in S. pygmaeus with potential implications for species connectivity and conservation.
Neuroprogression in bipolar disorder: why right is wrong
Authors: Vieta Eduard
Published: May 2024

The controversy on whether bipolar disorder is a neurodevelopmental versus a neuroprogressive illness is still around, despite some reductionistic claims that only one model is right. The current diagnostic classifications are not helpful to address this issue, and there is conflicting evidence in favor and against either model. In practice, though, understanding that many patients may show a progressive cognitive and functional decline which may be correlated with the number and severity of episodes may lead to better outcomes through early intervention strategies.
Cold War Austria and Migration from Eastern Europe: Refugees and Labor Migrants
Authors: Graf Maximilian
Published: May 2024

This article revisits Austria's migration history from the end of World War II until the end of the Cold War. Recent research has challenged the persistently commemorated welcoming Austrian attitude toward refugees who had been living under communism. The initial humanitarian efforts in 1956 and 1968, respectively, were remarkable. However, an analysis beyond the first weeks of both events reveals that (though to different degrees) public and political attitudes toward refugees took a negative turn. Throughout the 1970s, asylum for dissidents was portrayed as a continuation of the country's humanitarian tradition. However, in 1981, refugees from Poland were immediately perceived as unwanted labor migrants. In 1989/90, the scenario was similar: while the transiting East German refugees were welcomed, migrants from other countries (like Romania) were not. In the early 1990s, Austria decided on a reform of its asylum and foreigner policies. But when and why did the (supposedly welcome) refugees from countries under communist rule turn into unwelcome labor migrants? The analysis in this article explores the potential impact of the age of détente and the repercussions of the 1970s economic crises and the resulting end to active recruitment of foreign workers.
A better than
$3/2$
exponent for iterated sums and products over
$\mathbb R$
Authors: ROCHE–NEWTON OLIVER
Published: May 2024

In this paper, we prove that the bound
\begin{equation*}\max \{ |8A-7A|,|5f(A)-4f(A)| \} \gg |A|^{\frac{3}{2} + \frac{1}{54}}\end{equation*}
holds for all
$A \subset \mathbb R$
, and for all convex functions f which satisfy an additional technical condition. This technical condition is satisfied by the logarithmic function, and this fact can be used to deduce a sum-product estimate
\begin{equation*}\max \{ |16A|, |A^{(16)}| \} \gg |A|^{\frac{3}{2} + c},\end{equation*}
for some
$c\gt 0$
. Previously, no sum-product estimate over
$\mathbb R$
with exponent strictly greater than
$3/2$
was known for any number of variables. Moreover, the technical condition on f seems to be satisfied for most interesting cases, and we give some further applications. In particular, we show that
\begin{equation*}|AA| \leq K|A| \implies \,\forall d \in \mathbb R \setminus \{0 \}, \,\, |\{(a,b) \in A \times A : a-b=d \}| \ll K^C |A|^{\frac{2}{3}-c^{\prime}},\end{equation*}
where
$c,C \gt 0$
are absolute constants.
Images and Agency: Dynamics of Early Celtic Art and the Axial Age of Eurasia
Authors: Wells Peter S.
Published: May 2024

This paper argues for a new way of thinking about Early Celtic art in the context of changes taking place throughout Eurasia during the fifth and fourth centuries bce. It applies ideas of anthropologist Alfred Gell, among others, regarding art as a stimulus to action. It asks, in the spirit of papers by Chris Gosden and W.J.T. Mitchell, ‘what did the art do’? The paper argues that this complex new art can be understood in terms of agency contributing to and even stimulating aggressive attitudes and practices on the part of elites during the late fifth and early fourth centuries bce. The new worldviews that are apparent in the new style, and actions driven by them, played major roles in Iron Age Europeans’ participation in the so-called Axial Age of dynamic change throughout Eurasia.
Virtual reality modelling in a child after multiple interventions for hypoplastic aortic arch and coarctation
Authors: Szeliga Judyta , Lazu Maksym , Góreczny Sebastian
Published: May 2024

We present the benefits of advanced multimodality imaging and virtual reality modelling in the diagnosis and treatment planning of a child with aneurysms after numerous interventions for treatment of a hypoplastic aortic arch and coarctation.
The efficacy of the use of atropine in children with reflex anoxic syncope during pallid breath-holding spells: can cardiac pacemaker implantation be avoided?
Authors: Donné Marieke , Vandekerckhove Kristof , De Wilde Hans
Published: May 2024

Objectives:

Reflex anoxic syncope is the result of an overreaction of the vagal system, resulting in hypotension and bradycardia or brief cardiac arrest. Because of the benign character and the absence of complications in short or long term, treatment is only necessary in case of frequent or severe clinical presentation. Treatment options are anticholinergic drugs or cardiac pacemaker placement. We investigated atropine treatment and aimed to examine if pacemaker placement can be avoided.

Methods:

We retrospectively reviewed patients treated with atropine for severe reflex anoxic syncope in our centre from January 2017 until May 2023, and compared our results to those in the literature.

Results:

The study population consisted of 10 children, 70% female, with an age ranging from 5 months to 3 years (mean 14.5 months) when atropine treatment was started (dose 17–50 microg/kg/day). All patient’s parents reported adequate symptom management during atropine treatment, with complete resolution in 10%. Minor side effects were reported in 60% (dry mucosa in 40%, obstipation in 20%, and nausea or blurry vision in 10%).

Discussion:

We consider atropine a safe and effective treatment to manage reflex anoxic syncope with similar success rate to pacemaker implantation. However, pacemaker implantation entails substantial risk for complications (up to 25%) such as infection or technical problems and morbidity such as scar formation. This might be considered redundant for a benign and temporary condition, certainly given the possibility of other efficient treatment options. Consequently, we recommend atropine treatment over implantation of a cardiac pacemaker in children with severe reflex anoxic syncope.
Julie Christmas – President of BIALL
Authors: Breslin Mike
Published: May 2024

The current BIALL President, Julie Christmas, talks to LIM Co-Editors Mike and Jas Breslin about how she became a legal information manager, how she's trying to upgrade the technology to allow the organisation to function smoothly, and why she believes that the job title ‘law librarian’ should – just perhaps – be consigned to history.
Going Green: The BIALL Sustainability Working Group
Authors: Baird Christine , Miller John
Published: May 2024

‘Going Green: The BIALL Sustainability Working Group’ was a parallel session presented by Christine Baird during the BIALL Annual Conference ‘Gaining the edge: investing in our skillset’, held in Belfast in June 2023. The session aimed to provide an introduction to the newly formed BIALL Sustainability Working Group. The session, and this subsequent article, outlines the group's aims, projects and structure, as well as the wider contexts which motivated the group's establishment. It discusses the ways in which information professionals can develop more sustainable working practices, both individually and by leveraging the power of our professional networks. This paper explores the opportunities for legal librarians to engage in community activism, and the importance of both this concept and of ‘cathedral thinking’ in responding to the climate crisis.
Raiders of the lost archive
Authors: Breslin Mike , Breslin Jas
Published: May 2024

In the latest in our series reviewing archived copies of Legal Information Management and The Law Librarian – as the journal was once known – LIM's co-editors leaf through the issues of 1974.
High-gain TM11 mode equilateral triangular patch antenna with shorting pins and triangular short horn
Authors: Kumar Ashwani , Gautam Shatish K. , Arya Ravi K. , Ali Maifuz , Singh Praduman P. , Verma Anand K. , Mittra Raj
Published: May 2024

Normally, the reported gain of the microstrip patch antenna is within 8 dBi. Using properly located three shorting pins on three bisectors, the present work reports a method to convert the non-radiating TM11 mode of equilateral triangular patch antennas (ETPAs) to a deformed TM11 radiating mode. The boresight gain of ETPA operating in TM11 mode is enhanced from −10.75 to 12.1 dBi at 5.43 GHz. The boresight measured gain is further enhanced to 14.2 dBi at 5.52 GHz by using a triangular surface-mounted short horn (SMSH) of about ${{\lambda }}/5$ height. The aperture efficiency of the ETPA with the shorting pins is 84.2%. The aperture efficiency is further improved to 94.2% using the SMSH. The measured boresight cross-polarization and side-lobe level are −40 and −29 dB, respectively. The nature of the electricfield and surface current distribution is analyzed, using both the characteristic mode analysis method and high-frequency structure simulator, to understand the role of shorting pin and coaxial feed in converting the non-radiating TM11 mode to the radiating mode. A systematic design process also is presented for a fast design of shorting pin-loaded ETPA on the suitable substrate at a specified frequency.
Machine‐Learning Based Identification of the Critical Driving Factors Controlling Storm‐Time Outer Radiation Belt Electron Flux Dropouts
Authors: Hua Man , Bortnik Jacob , Ma Donglai
Published: May 2024

Understanding and forecasting outer radiation belt electron flux dropouts is one of the top concerns in space physics. By constructing Support Vector Machine (SVM) models to predict storm‐time dropouts for both relativistic and ultra‐relativistic electrons over L = 4.0–6.0, we investigate the nonlinear correlations between various driving factors (model inputs) and dropouts (model output) and rank their relative importance. Only time series of geomagnetic indices and solar wind parameters are adopted as model inputs. A comparison of the performance of the SVM models that uses only one driving factor at a time enables us to identify the most informative parameter and its optimal length of time history. Its accuracy and the ability to correctly predict dropouts identifies the SYM‐H index as the governing factor at L = 4.0–4.5, while solar wind parameters dominate the dropouts at higher L‐shells (L = 6.0). Our SVM model also gives good prediction of dropouts during completely out‐of‐sample storms.
Using NIW Observations to Assess Mixed Layer Parameterizations: A Case Study in the Tropical Atlantic
Authors: Mrozowska M. A. , Jochum M. , Bastin S. , Hummels R. , Koldunov A. , Dengler M. , Fischer T. , Nuterman R. , Hansen R. R.
Published: May 2024

Tropical sea surface temperature (SST) biases can cause atmospheric biases on global scales, hence SST needs to be represented well in climate models. A major source of uncertainties is the representation of turbulent mixing in the oceanic boundary layer, or mixed layer (ML). In the present study we focus on near‐inertial wave (NIW) induced mixing. The performance of two mixing schemes, Turbulent Kinetic Energy and K‐profile parameterization (KPP), is assessed at two sites (11.5°N, 23°W and 15°N, 38°W) in the tropical Atlantic. At 11.5°N, turbulence observations (eddy diffusivities, shear and stratification) are available for comparison. We find that the schemes differ in their representation of NIWs, but both under‐represent the observed enhanced diffusivities below the observed ML. However, we find that the models do mix below the ML at 15°N when a storm passes nearby. The near‐inertial oscillations remain below the ML for the following 10 days. Near‐inertial kinetic energy (NIKE) biases in the models are not directly correlated with the wind speed, the MLD biases, or the stratification at the ML base. Instead, NIKE biases are sensitive to the vertical mixing scheme parameterization. NIKE biases are lowest when the KPP scheme is used.
Prevention of infective endocarditis in at-risk patients: how should dentists proceed in 2024?
Authors: Thornhill Martin , Prendergast Bernard , Dayer Mark , Frisby Ash , Lockhart Peter , Baddour Larry M.
Published: May 2024

National Institute for Health and Care Excellence (NICE) guidelines are ambiguous over the need for patients at increased risk of infective endocarditis (IE) to receive antibiotic prophylaxis (AP) prior to invasive dental procedures (IDPs), and this has caused confusion for patients and dentists alike. Moreover, the current law on consent requires clinicians to ensure that patients are made aware of any material risk they might be exposed to by any proposed dental treatment and what can be done to ameliorate this risk, so that the patient can decide for themselves how they wish to proceed. The aim of this article is to provide dentists with the latest information on the IE-risk posed by IDPs to different patient populations (the general population and those defined as being at moderate or high risk of IE), and data on the effectiveness of AP in reducing the IE risk in these populations. This provides the information dentists need to facilitate the informed consent discussions they are legally required to have with patients at increased risk of IE about the risks posed by IDPs and how this can be minimised. The article also provides practical information and advice for dentists on how to manage patients at increased IE risk who present for dental treatment.
Graph machine learning for integrated multi-omics analysis
Authors: Valous Nektarios A. , Popp Ferdinand , Zörnig Inka , Jäger Dirk , Charoentong Pornpimol
Published: May 2024

Multi-omics experiments at bulk or single-cell resolution facilitate the discovery of hypothesis-generating biomarkers for predicting response to therapy, as well as aid in uncovering mechanistic insights into cellular and microenvironmental processes. Many methods for data integration have been developed for the identification of key elements that explain or predict disease risk or other biological outcomes. The heterogeneous graph representation of multi-omics data provides an advantage for discerning patterns suitable for predictive/exploratory analysis, thus permitting the modeling of complex relationships. Graph-based approaches—including graph neural networks—potentially offer a reliable methodological toolset that can provide a tangible alternative to scientists and clinicians that seek ideas and implementation strategies in the integrated analysis of their omics sets for biomedical research. Graph-based workflows continue to push the limits of the technological envelope, and this perspective provides a focused literature review of research articles in which graph machine learning is utilized for integrated multi-omics data analyses, with several examples that demonstrate the effectiveness of graph-based approaches.
Synergistic polarization engineering of dielectric towards low-voltage high-mobility solution-processed ultraflexible organic transistors
Authors: Zhang Mingxin , Wang Xue , Sun Jing , Tong Yanhong , Zhang Cong , Yu Hongyan , Guo Shanlei , Zhao Xiaoli , Tang Qingxin , Liu Yichun
Published: May 2024

The emerging wearable skin-like electronics require the ultra-flexible organic transistor to operate at low voltage for electrical safety and energy efficiency and simultaneously enable high field-effect mobility to ensure the carrier migration ability and the switching speed of circuits. However, the currently reported low-voltage organic transistors generally present low mobility, originating from the trade-off between molecular polarity and surface polarity of the dielectrics. In this work, the orientation polarization of the dielectric is enhanced by introducing a flexible quaternary ammonium side chain, and the surface polarity is weakened by the shielding effect of the nonpolar methyl groups on the polar nitrogen atom. The resulting antisolvent QPSU dielectric enables the high-dielectric constant up to 18.8 and the low surface polarity with the polar component of surface energy only at 2.09 mJ/m2. Such a synergistic polarization engineering between orientation polarization and surface polarity makes the solution-processed ultraflexible transistors present the ultralow operational voltage down to −3 V, the ultrahigh charge-carrier mobility up to 8.28 cm2 V−1 s−1 at 1 Hz, excellent cyclic operational stability and long-term air stability. These results combined with the ultrathin thickness of transistor as low as 135 nm, the ultralight mass of 0.5 g/m2, the conformal adherence capability on human skin and 1-μm blade edge, and the strong mechanical robustness with stable electrical properties for 30,000 bending cycles, open up an available strategy to successfully realize low-voltage high-mobility solution-processed organic transistor, and presents the potential application of QPSU dielectric for the next-generation wearable imperceptible skin-like electronics.
Prevalence and associated factors of noise-induced hearing loss among workers in Bishoftu Central Air Base of Ethiopia
Authors: Hailu Ashenafi , Zeleke Birhanu , Ermias Zeberihe , Duguma Fasil Kenea , Dula Sara , Abaya Samson Wakuma , Shegen Seblework Mekonen , Tucho Gudina Terefe , Afata Tariku Neme
Published: May 2024

Excessive occupational exposure to noise results in a well-recognized occupational hearing loss which is prevalent in many workplaces and now it is taken as a global problem. Therefore, this study aims to assess the prevalence of noise-induced hearing loss and associated factors among workers in the Bishoftu Central Air Base in Ethiopia. An institutional-based cross-sectional study was conducted among 260 central air base workers through face-to-face interviews, an environment noise survey, and an audiometric test for data collection. Data were entered by Epi-data version 3.1 and SPSS was used to analyze the data. Finally, a statistical analysis such as descriptive and binary logistic regression analysis was applied. A P-value < 0.05 at 95% CI was considered statistically significant. The overall prevalence of noise-induced hearing loss and hearing impairments was 24.6 and 30.9%, respectively. The highest prevalence of noise-induced hearing loss was recorded for workers who were exposed to noise levels greater than 90 dBA. Out of 132 workers exposed to the average noise level of 75 dB A, only 5% of workers were affected with noise-induced hearing loss, while 128 workers exposed to an average noise level equal to or greater than 90 dB A, 19.6% of workers were identified with noise-induced hearing loss. Regarding sex, around 21.9% of male workers were identified with noise-induced hearing loss. Workers who were exposed to a high noise level workplace previously or before the Central Air Base workplace were five times (AOR = 5.0, 95% CI 1.74–14.36) more likely affected by noise-induced hearing loss than those workers not previously exposed. Those workers who were exposed to greater or equal to 90dBA noise level were 4.98 times (AOR = 4.98, 95% CI 2.59–9.58) more likely to be exposed to noise-induced levels than those who were exposed to less than 90dBA noise level. Moreover, male air base workers were 3.5 times more likely exposed to hearing impairment than female workers (AOR = 3.5, 95% CI 1.01–12.0). This study identified that the prevalence of noise-induced hearing loss and hearing impairments was significantly high. So implementation of a hearing conservation program, giving noise education, and supplying adequate hearing protective devices (HPDs) are essentials.
Regional nigral neuromelanin degeneration in asymptomatic leucine-rich repeat kinase 2 gene carrier using MRI
Authors: Gao Linlin , Gaurav Rahul , Ziegner Pia , Ma Jinghong , Sun Junyan , Chen Jie , Fang Jiliang , Fan Yangyang , Bao Yan , Zhang Dongling , Chan Piu , Yang Qi , Fan Zhaoyang , Lehéricy Stéphane , Wu Tao
Published: May 2024

Asymptomatic Leucine-Rich Repeat Kinase 2 Gene (LRRK2) carriers are at risk for developing Parkinson's disease (PD). We studied presymptomatic substantia nigra pars compacta (SNc) regional neurodegeneration in asymptomatic LRRK2 carriers compared to idiopathic PD patients using neuromelanin-sensitive MRI technique (NM-MRI). Fifteen asymptomatic LRRK2 carriers, 22 idiopathic PD patients, and 30 healthy controls (HCs) were scanned using NM-MRI. We computed volume and contrast-to-noise ratio (CNR) derived from the whole SNc and the sensorimotor, associative, and limbic SNc regions. An analysis of covariance was performed to explore the differences of whole and regional NM-MRI values among the groups while controlling the effect of age and sex. In whole SNc, LRRK2 had significantly lower CNR than HCs but non-significantly higher volume and CNR than PD patients, and PD patients significantly lower volume and CNR compared to HCs. Inside SNc regions, there were significant group effects for CNR in all regions and for volumes in the associative region, with a trend in the sensorimotor region but no significant changes in the limbic region. PD had reduced volume and CNR in all regions compared to HCs. Asymptomatic LRRK2 carriers showed globally decreased SNc volume and CNR suggesting early nigral neurodegeneration in these subjects at risk of developing PD.
Behavioral evidence of impaired self-referential processing in patients with affective disorders and first-episode schizophrenia
Authors: Zhao Yanli , Xu Jiahua , Hong Jiangyue , Xu Xuejing , Fan Hongzhen , Zhang Jinguo , Li Dong , Chen Jingxu , Wu Yaxue , Li Yanli , Tan Yunlong , Tan Shuping
Published: May 2024

Despite the critical role of self-disturbance in psychiatric diagnosis and treatment, its diverse behavioral manifestations remain poorly understood. This investigation aimed to elucidate unique patterns of self-referential processing in affective disorders and first-episode schizophrenia. A total of 156 participants (41 first-episode schizophrenia [SZ], 33 bipolar disorder [BD], 44 major depressive disorder [MDD], and 38 healthy controls [HC]) engaged in a self-referential effect (SRE) task, assessing trait adjectives for self-descriptiveness, applicability to mother, or others, followed by an unexpected recognition test. All groups displayed preferential self- and mother-referential processing with no significant differences in recognition scores. However, MDD patients showed significantly enhanced self-referential recognition scores and increased bias compared to HC, first-episode SZ, and BD. The present study provides empirical evidence for increased self-focus in MDD and demonstrates that first-episode SZ and BD patients maintain intact self-referential processing abilities. These findings refine our understanding of self-referential processing impairments across psychiatric conditions, suggesting that it could serve as a supplementary measure for assessing treatment response in first-episode SZ and potentially function as a discriminative diagnostic criterion between MDD and BD.
Climate change could negate U.S. forest ecosystem service benefits gained through reductions in nitrogen and sulfur deposition
Authors: Phelan Jennifer N. , Van Houtven George , Clark Christopher M. , Buckley John , Cajka James , Hargrave Ashton , Horn Kevin , Thomas R. Quinn , Sabo Robert D.
Published: May 2024

Climate change and atmospheric deposition of nitrogen (N) and sulfur (S) impact the health and productivity of forests. Here, we explored the potential impacts of these environmental stressors on ecosystem services provided by future forests in the contiguous U.S. We found that all stand-level services benefitted (+ 2.6 to 8.1%) from reductions in N+S deposition, largely attributable to positive responses to reduced S that offset the net negative effects of lower N levels. Sawtimber responded positively (+ 0.5 to 0.6%) to some climate change, but negatively (− 2.4 to − 3.8%) to the most extreme scenarios. Aboveground carbon (C) sequestration and forest diversity were negatively impacted by all modelled changes in climate. Notably, the most extreme climate scenario eliminated gains in all three services achieved through reduced deposition. As individual tree species responded differently to climate change and atmospheric deposition, associated services unique to each species increased or decreased under future scenarios. Our results suggest that climate change should be considered when evaluating the benefits of N and S air pollution policies on the services provided by U.S. forests.
Antireflection microstructures on ZnSe for mid- and far-IR fabricated by femtosecond laser ablation assisted with wet chemical etching
Authors: Teslenko Andrei , Konstantinova Tatiana , Bushunov Andrey , Ibragimov Artem , Rodionov Ilya , Tarabrin Mikhail
Published: May 2024

Most infrared materials used in high-power systems, such as optical parametric generators, have high values of refractive indices, which result in high Fresnel losses. The performance of conventional antireflection coatings is limited when used in high-power and ultra-broadband systems. An alternative approach is to fabricate antireflection microstructures (ARMs) that allow for a broadband increase in transmittance without reducing the damage threshold of the material. In this work, ARMs were fabricated on the surface of ZnSe crystals using the femtosecond laser ablation assisted with wet chemical etching method. This allowed to produce high aspect ratio microstructures that increase the transmittance up to 98% in the mid- and far- infrared regions.
Analysis of the outage performance of energy-harvesting cooperative-NOMA system with relay selection methods
Authors: Zhou Yulin , Zhang Yang , Khuwaja Aziz Altaf , Wang Zhao , Zhang Qifei
Published: May 2024

Recent years have witnessed the remarkable progress in wireless communication systems due to the escalating demand for higher data rates, improved reliability, and increased energy efficiency. In this regard, Non-Orthogonal Multiple Access (NOMA) has emerged as a promising technology, enhancing spectral efficiency and accommodating multiple users concurrently within the same time and frequency resources. Simultaneously, the energy harvesting has surfaced as a sustainable solution, converting ambient environmental energy into usable electrical power for operating communication nodes. This paper proposes a cooperative NOMA transmission scheme integrating energy harvesting and utilizing Least Squares (LS) channel estimation for precise Channel State Information (CSI) acquisition. The objective is to establish an optimal communication path from source to destination. Relay selection methods: Optimal Relay Selection (ORS) and Max-Min Relay Selection (MMRS), are compared, focusing on their impact on the system performance. The analysis considers the influence of the number of relays and power allocation factor on the system, with a specific emphasis on the outage probability expressions. Comparative analysis between the cooperative-NOMA and the traditional cooperative relaying without NOMA reveals the superior performance of the cooperative-NOMA. Additionally, the ORS scheme outperforms MMRS in terms of the outage performance.
The role of bipolar disorder and family wealth in choosing creative occupations
Authors: Biasi Barbara , Dahl Michael S. , Moser Petra
Published: May 2024

Research in psychology and medicine has linked mental health disorders, and particularly bipolar disorder (BD), to employment in creative professions. Little is known, however, about the mechanisms for this link, which could be due to biology (primarily through a person’s genes) or environmental (through socioeconomic status). Using administrative data on mental health diagnoses and occupations for the population of Denmark, we find that people with BD are more likely to be musicians than the population, but less likely to hold other creative jobs. Yet, we also show that healthy siblings of people with BD are significantly more likely to work in creative professions. Notably, people from wealthy families are consistently more likely to work in creative professions, and access to family wealth amplifies the likelihood that siblings of people with BD pursue creative occupations. Nevertheless, family wealth explains only a small share of the correlation between BD and creative employment.
A novel development of a new single switch inductor coupled DC-DC converter for PV system with two-leg inverter
Authors: Samiulla Shaik Moulana , Rachananjali Kunamneni
Published: May 2024

From the power generation history, the nonrenewable power sources utilization is falling extremely because of their demerits are high atmospheric pollution, more expensive, more catchment area for development, high fossil fuel transportation cost, less flexibility, and reliability. So, the sunlight systems are utilized in this work for feeding the power to the central grid. On the earth, the sunlight energy availability is more and it is more flexible for the installation. However, the sunlight photovoltaic (PV) module’s power production is very low. To improve the power generation of the PV network, a modified slider maximum power point tracking (MPPT) controller is proposed in the first objective and it is interfaced with the sunlight system for capturing more sunlight insolation thereby moving the functioning point of the solar system from local MPP place to required global MPP place. The features of this sliding controller are continuous peak power production, easy development, less power dissipation losses, plus good dynamic system response. In the second objective, the available voltage of the PV is low which improved from low level to high level by utilizing the Wide voltage supply-inductor coupled converter. The development of this circuit needed very less inductive, plus capacitive components. Also, it is developed by selecting a single switch. As a result, the entire network power production cost is reduced. In the third objective, a two-leg inverter is proposed for the transformation of the DC voltage supply into three-phase powers. The MATLAB/Simulink tool is used to investigate the overall system.
CVD graphene contacts for lateral heterostructure MoS2 field effect transistors
Authors: Schneider Daniel S. , Lucchesi Leonardo , Reato Eros , Wang Zhenyu , Piacentini Agata , Bolten Jens , Marian Damiano , Marin Enrique G. , Radenovic Aleksandra , Wang Zhenxing , Fiori Gianluca , Kis Andras , Iannaccone Giuseppe , Neumaier Daniel , Lemme Max C.
Published: May 2024

Intensive research has been carried out on two-dimensional materials, in particular molybdenum disulfide, towards high-performance field effect transistors for integrated circuits1. Fabricating transistors with ohmic contacts is a challenging task due to the formation of a high Schottky barrier that severely limits the performance of the transistors for real-world applications. Graphene-based heterostructures can be used in addition to, or as a substitute for unsuitable metals. In this paper, we present lateral heterostructure transistors made of scalable chemical vapor-deposited molybdenum disulfide and chemical vapor-deposited graphene achieving a low contact resistances of about 9 kΩ·µm and high on/off current ratios of 108. Furthermore, we also present a theoretical model calibrated on our experiments showing further potential for scaling transistors and contact areas into the few nanometers range and the possibility of a substantial performance enhancement by means of layer optimizations that would make transistors promising for use in future logic integrated circuits.
Testing functional anchor groups for the efficient immobilization of molecular catalysts on silver surfaces
Authors: Bunjes Ole , Rittmeier Alexandra , Hedman Daniel , Hua Shao-An , Paul Lucas A. , Meyer Franc , Ding Feng , Wenderoth Martin
Published: May 2024

Modifications of complexes by attachment of anchor groups are widely used to control molecule-surface interactions. This is of importance for the fabrication of (catalytically active) hybrid systems, viz. of surface immobilized molecular catalysts. In this study, the complex fac-Re(S-Sbpy)(CO)3Cl (S-Sbpy = 3,3′-disulfide-2,2′-bipyridine), a sulfurated derivative of the prominent Re(bpy)(CO)3Cl class of CO2 reduction catalysts, was deposited onto the clean Ag(001) surface at room temperature. The complex is thermostable upon sublimation as supported by infrared absorption and nuclear magnetic resonance spectroscopy. Its anchoring process has been analyzed using scanning tunneling microscopy (STM) and density functional theory (DFT) calculations. The growth behavior was directly contrasted to the one of the parent complex fac-Re(bpy)(CO)3Cl (bpy = 2,2′-bipyridine). The sulfurated complex nucleates as single molecule at different surface sites and at molecule clusters. In contrast, for the parent complex nucleation only occurs in clusters of several molecules at specifically oriented surface steps. While this shows that surface immobilization of the sulfurated complex is more efficient as compared to the parent, symmetry analysis of the STM topographic data supported by DFT calculations indicates that more than 90% of the complexes adsorb in a geometric configuration very similar to the one of the parent complex.