bluuebunny/crossref_metadata_2025 huggingface dataset:
Irrational Foundations of Suicide
Authors:   Siberian Law Institute, Ministry of Internal Affairs of Russia, Roman G. Roman G.
Published: June 2022

The article discusses theoretical studies on suicides and suicidal behavior, discusses the features of the development of this phenomenon in different social groups, provides a general typology of studies already conducted through the prism of understanding the impact of social experience (external pressure factors, crisis, stressful situations) and intrapersonal problems (related to personality traits, socialization and adaptation of a person to external influences and internal experiences and processes). The paper also presents the results of a comprehensive study of the irrational foundations of suicide. The first is based on an analysis of the materials of a quantitative survey of Russians (n-1200) conducted in 2022 in all regions of the Russian Federation. The second one is constructed on the interpretation of qualitative data ‒ the analysis of expert interviews (n-18), psychologists, psychotherapists, psychiatrists, philosophers, criminologists. The third is the analysis of articles and publications in social networks devoted to suicides and promoting suicidal behavior (n-1620), which made it possible to identify key semantic lexemes that indicate the main causes and factors in the development of suicidal behavior and suicides. As a result of the study, we identified nine of them: 1) age (17–21, 40–45, 55–65); 2) limitation of emotional and sensory experience; 3) difficulties in building communications due to their own incompetence or limited opportunities; 4) problems of self-determination in society (conflict with a group, forced confrontation ‒ in the family, at work, among friends); 5) weakly expressed own worldview; 6) feeling of loneliness; 7) a sharp stratification of people in terms of the level and quality of life; 8) social inertia and frustration; 9) destructive hobbies (drug addiction, drunkenness). The use of these research methods made it possible to supplement and expand the initial materials and data of the work, to reveal the potential for interaction at the methodological and practical level and to identify several prospects for topics for further scientific research. It is indicated that the quality of life is based on the ability to predict the future, the prevention of suicidal behavior and suicide can become the basis for social stability and social reproduction.
The Translation Process of Pharmaceutical Care Network Europe v9.00 to Bahasa Indonesia: An Instrument to Detect Drug-Related Problem
Authors:   Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, Indonesia, Satria Muhammad Aldila , Andrajati Retnosari ,   Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, Indonesia, Supardi Sudibyo ,   National Institute of Health Research and Development, Indonesian Ministry of Health, Jakarta, Indonesia
Published: June 2022

Background: Drug-related problems (DRPs) remain a major health challenge in tertiary health services such as hospitals in Indonesia. These problems are detected and solved using classification systems such as Pharmaceutical Care Network Europe (PCNE). Therefore, this study aims to obtain a valid and reliable Bahasa Indonesia version of the PCNE. Methods: A draft of the Bahasa Indonesia version of the PCNE v9.00 was discussed by four experts from May to August 2020 using the Delphi method. Furthermore, the instrument was assessed for its readability, clarity and comprehensiveness by 46 hospital pharmacists throughout Indonesia. In October 2020, two pharmacists from Haji General Hospital, Makassar, Indonesia carried out the inter-rater agreement to assess 20 cases where the proportion of coding matches between both raters were observed. Results: The instrument was found to be valid after passing the face and content validity, and the Scale Content Validity Index (S-CVI) value for each PCNE domain was 0.91, 0.89, 0.93, 0.97 and 0.93, respectively. Moreover, there was a fair agreement between the two raters that ranged between 40%–90%. Also, kappa statistics showed a substantial agreement on the ‘Problems’ and ‘Causes’ domains. Conclusion: The Bahasa Indonesia version of the PCNE v9.00 instrument passed face and content validity as well as inter-agreement to be used in hospital settings.
Sepsis and Its Impact on Outcomes in Elderly Patients Admitted to a Malaysian Intensive Care Unit
Authors:   Department of Anaesthesiology and Intensive Care, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia, Wan Muhd Shukeri Wan Fadzlina , Mat Nor Mohd Basri ,   Department of Anaesthesiology and Critical Care, Kuliyyah of Medicine, International Islamic Universiti Malaysia, Pahang, Malaysia, Md Ralib Azrina ,   Department of Anaesthesiology and Critical Care, Kuliyyah of Medicine, International Islamic Universiti Malaysia, Pahang, Malaysia
Published: June 2022

Sepsis is an important cause of morbidity and mortality in elderly patients, but there is a scarcity of data on sepsis in this specific cohort. We performed this study to review the impact of sepsis on outcomes in elderly patients admitted to our local intensive care unit (ICU). This was a secondary analysis of prospectively collected data of 159 consecutive adult patients with sepsis admitted to an ICU of a tertiary hospital in Malaysia over a three-year period. Of the 159 patients analysed, elderly patients constituted 18.9% of the cohort. Fifty percent of the older patients died within 30 days, compared to 24% of younger patients (P = 0.005). On multivariate analysis, old age was found to be independently predictive of 30-day mortality with an adjusted odds ratio (OR) of 2.5 (95% confidence interval [CI]: 1.05, 6.01) compared to younger patients (P = 0.021). In a Kaplan-Meier analysis, survival probability was significantly lower in patients of an older age compared to younger patients (P = 0.015). In conclusion, mortality from sepsis is considerably higher in elderly patients, with age as an independent risk factor for mortality.
Features of lymphocyte differentiation in ANCA-associated and virus-associated glomerulonephritis in children
Authors:   St Petersburg State Pediatric Medical University, Gurina Olga , Dementyeva Elena ,   St Petersburg State Pediatric Medical University, Stepanova Arina ,   St Petersburg State Pediatric Medical University, Blinov Aleksandr ,   St Petersburg State Pediatric Medical University, Varlamova Olga ,   St Petersburg State Pediatric Medical University
Published: June 2022

Glomerulonephritis is a heterogeneous group of immuno-inflammatory diseases. The purpose of the study: to analyze the subpopulation composition of lymphocytes in children with various types of glomerulonephritis. 50 children aged 1 to 16 years were examined: 1 group — 17 children aged 1 to 16 years with ANCA-associated glomerulonephritis; 2 group — 33 patients aged 2 to 16 years with virus-associated glomerulonephritis. Diagnostics of the subpopulation composition of lymphocytes was performed by flow cytometry using non-flushing technology using a three-color combination of monoclonal antibodies. It was found that the development of ANCA-associated glomerulonephritis is accompanied by signs of immunodeficiency against the background of a relative increase in the content of T-lymphocyte subpopulations. Differentiation of lymphocytes in children with virus-associated glomerulonephritis is ambiguous: the process goes either along the path of activation of antiviral protection, or along the path of development of insufficient antiviral activity of immunocytes. In children with virus-associated glomerulonephritis, a decrease in the level of B-lymphocytes was found, correlating with hypoimmunoglobulinemia A, which is an additional factor in reducing resistance on the mucous membranes. The study of lymphocyte differentiation in the development of glomerulonephritis is important for identifying the main immunological mechanisms involved in the pathogenesis of these diseases.
Possibility of using of international classification of functioning in rehabilitation of patients with cataract
Authors:   North-Western State Medical Mechnikov University, Klyushnikova Elena
Published: June 2022

The problem of rehabilitation of patients with cataract, analysis of effectiveness of surgical treatment, restoration of professional activity and obtaining a high quality of life after cataract surgery is of great medical and social importance. The basic principles of modern medicine are patient orientation, personalized and multidisciplinary approach. Attention is focused not on an individual disease and its symptoms, but on the patient as a whole person with all life’s concerns and problems. The study of the quality of life (QOL) of the patients with cataract allows us to assess the influence of cataract and surgical treatment on the psychological, emotional state of the patient, his functioning in the social environment. However, cataract surgery is a rehabilitation treatment aimed at restoring functions lost due to cataract. International classification of functioning (ICF), limitation of vital activity and health is a generally accepted classification in rehabilitation medicine. In accordance with new trends, the possibility of using ICF for the study of visual impairments and limitation of vital activity in patients with cataract before and after surgical treatment is becoming relevant.
Methodological aspects of programs’ updating for advanced training of doctors
Authors:   St. Petersburg State University, Tregubov Aleksey , Shurygina Valeriia ,   St. Petersburg State University, Perepech Nikita ,   St. Petersburg State University
Published: June 2022

An important component of improving the healthcare system is providing medical institutions with highly qualified personnel. In the era of evidence-based medicine, clinical guidelines developed by the expert community and approved by regulatory authorities are the cornerstone of maintaining the knowledge and skills of medical personnel at a high level. In modern medicine, new data are accumulating very quickly, which requires regular changes in the algorithms for managing specialized patients. Frequent updating of clinical guidelines and their increasing importance as a document regulating the provision of medical care to patients with various diseases necessitate the intensification of additional professional education of doctors. Doctors’ awareness of the current provisions of clinical guidelines and readiness to implement them in everyday practice is an important condition for the compliance of real medical care with modern requirements. Under the conditions of the system of continuous medical education, the programs for improving the skills of doctors should be constantly improved. The article discusses the methodology for updating educational programs based on the analysis of the results of an anonymous survey of doctors on the main aspects of the current clinical guidelines. Identification of questions, the answers to which turn out to be incorrect more often than others, and quantitative analysis of the distribution of incorrect answers allow to correct programs in order to achieve a higher level of knowledge of trainees in the most difficult sections of clinical guidelines. Information about the changes that were made to the advanced training programs for doctors in the diagnosis and treatment of cardiovascular diseases on the basis of the data obtained during the questionnaire is presented. It is expected that the discussed methodology for updating the advanced training programs for doctors will help to improve the provision of the needs of modern healthcare for highly qualified personnel.
Insurance law in Poland
Authors:   Adam Mickiewicz University, Orlicki Marcin
Published: June 2022

In recent years Polish insurance law has undergone a series of rapid changes. The key driving force behind these changes has been the need to adapt national legal regulations to requirements of Community law. Consumer pressure has also been a powerful influence, as a result of which insurance services are gradually becoming more customer-friendly. Polish laws on insurance contracts have been developing primarily in the following directions: strengthening the position of insurance service customers, creating dedicated regulations for group insurance, extending the scope of compulsory insurance, ensuring full compensation for traffic accident damages, and regulation of insurance distribution business (including insurance intermediaries). This article discusses basic issues of insurance law under the Polish legal system and general trends in its development, especially as regards adapting national regulations to requirements of European Union, the strengthening of the position of the customers buying insurance services, creation of regulations dedicated for group insurance, and extending the scope of compulsory insurance and ensuring full compensation for traffic accident damages. In particular, the article addresses issues of insurance contracts, protection of clients of insurance services (favoring customers concluding and delivery of insurance contracts), compulsory insurance, insurance concluded on behalf of a third party, group insurance, and new rules of insurance distribution in European and Polish law. The article indicates the main legislative acts of the Polish insurance law and the most important decisions and resolutions of the Polish Supreme Court.
Agricultural law in Poland
Authors:   Adam Mickiewicz University, Budzinowsk Roman
Published: June 2022

This article explores characteristics of Polish agricultural law as a branch of legislation, a branch in the legal system, a detailed scientific discipline, and as a subject of teaching. The development of agricultural legislation has always been accompanied by the study of agricultural law and, as a rule, its teaching. Concerning its origins, agricultural law in Poland is more related to public law regulations. At the end of the 19th century and at the beginning of the 20th century, the instruments for influencing agriculture proper to this law were developed. In the interwar period, legislation on various aspects of agriculture developed, but fell primarily within the scope of public law. It was only in the 1950s, during the period of the People’s Republic of Poland, that civil law regulation on agriculture, in addition to public law regulation, developed. The change of regime after 1989 brought about a significant reduction in agricultural legislation due to economic liberalism. A significant development occurred only after Poland’s accession to the European Union. Many issues were regulated for the first time, and national law, in connection with EU membership, returned to a special regulation of agricultural property trade. The inclusion of Polish agriculture in the mechanisms of the CAP provided an impulse to intensify research and opened up a new stage in the development of the science of agricultural law, it has moved from the study of national law, to taking up topics of a regional and global nature under the conditions of EU membership. The research went beyond traditional land issues and the organization of agricultural production. The development of agricultural legislation and agricultural law science is linked to teaching. In the last few years or so, the position of agricultural law as a subject of teaching has been strengthened.
Recensão do Livro Rockonomics: O Que a Indústria da Música Nos Pode Ensinar Sobre Economia e Sobre a Vida
Authors: Sampaio Daniel Morgado
Published: June 2022

Rockonomics (Krueger, 2019/2020) é, até à data, a única obra póstuma deixada por Alan B. Krueger, uma obra na qual expande as suas análises de várias facetas da indústria musical. Krueger, docente na Universidade de Princeton com uma extensa produção académica, colaborador do The New York Times, principal economista do Departamento de Trabalho dos Estados Unidos durante a presidência de Bill Clinton e detentor de diferentes cargos ao longo da presidência de Barack Obama, entre eles a chefia do Conselho Económico dessa administração, tornou-se um nome familiar para o grande público com o seu primeiro livro, escrito em coautoria com o economista David Card...
Digital Political Communication in the Portuguese-Speaking World: Platformization and Engagement
Authors: García-Orosa Berta
Published: June 2022

This article provides an exhaustive analysis of the emerging digital political communication strategies in a seldom-studied area: the Portuguese-speaking world. Through a literature review and content analysis, 25 political parties from five countries and three different continents are studied. The results confirm emerging trends common to other recently analyzed places, such as innovation in digital storytelling, platformization and the trend towards engagement as communicative interaction. However, there are new trends toward instant messaging, podcasting, audience segmentation and engagement linked to the fight against fake news.
Entre a Emergência e a Transformação: Unindo Pontos, Tecendo Laços
Authors: Silva Ana Maria Costa e , Morgado Margarida , Hřebačková Monika
Published: June 2022

Pensar as sociedades contemporâneas, particularmente nos últimos 3 anos, inclui necessariamente recorrer às diversas experiências sensoriais: o que observamos, ouvimos, sentimos, fazemos. Vivemos tempos de crise social e contextos de emergência devido à situação pandémica da COVID-19, a nível mundial; um fenómeno extensivo a todos os continentes e populações, que deu visibilidade à força e à fragilidade da globalização, à interdependência geográfica, económica e social de continentes, países, instituições e pessoas. Assistimos chocados ao deflagrar da guerra e à escalada de agressividade não apenas em locais longínquos e noutros continentes, mas suficientemente próximo de onde vivemos para despoletar em nós a reflexão sobre a defesa confiável da liberdade e dos valores europeus. Face às manifestações visíveis no confronto, nas mortes e na guerra verbal e física, na dicotomia entre o ocidente e o oriente, reconhecemos a importância do diálogo e da mediação para a defesa dos direitos humanos e da paz no mundo...
SUMBER BELAJAR ALTERNATIF MATA KULIAH AKUNTANSI BAGI MAHASISWA GENERASI Z
Authors: Sari Padma Adriana , Fazda Oktavia Fathimatus Zahro
Published: June 2022

Penyesuaian dan inovasi pada proses pembelajaran diperlukan  untuk memenuhi kebutuhan mahasiswa generasi Z terutama di era pembelajaran online seperti saat ini sehingga tercapai proses pembelajaran yang efektif. Tujuan penelitian ini adalah untuk mengetahui sumber belajar yang diminati oleh mahasiswa generasi Z serta alternatif sumber belajar yang telah digunakan oleh dosen pengajar akuntansi. Teknik survei digunakan dalam penelitian ini untuk mengumpulkan data. Kuesioner dibagikan secara online kepada mahasiswa akuntansi serta dosen akuntansi di beberapa universitas dan politeknik di Indonesia. Data yang dikumpulkan dianalisis dengan metode deskriptif. Hasil penelitian menyebutkan bahwa sumber belajar yang digunakan dosen akuntansi telah sesuai dengan kebutuhan mahasiswa generasi Z, yaitu menggunakan video pembelajaran, modul serta perpaduan berbagai sumber belajar lain dalam mata kuliah akuntansi. Video pembelajaran yang diinginkan responden mahasiswa adalah yang menarik, disertai animasi, contoh kasus di lapangan serta contoh soal dan pembahasannya. Hasil penelitian ini diharapkan untuk dijadikan referensi oleh dosen akuntansi yang sedang mencari alternatif sumber belajar untuk mengajarkan mata kuliah akuntansi di kelas, terutama dalam menghadapi generasi Z yang membutuhkan kondisi belajar yang menarik dan menyenangkan pada proses pembelajaran online di era pandemi seperti saat ini.
PENGARUH GAYA KEPEMIMPINAN TRANSFORMASIONAL, MOTIVASI KERJA, DAN DISIPLIN KERJA TERHADAP KINERJA GURU (STUDI KASUS GURU AKUNTANSI KEJURUAN BISNIS DAN MANAJEMEN SMK DI JAKARTA PUSAT)
Authors: Nena Milenia Febriyanti , Zulaihati Sri , Sumiati Ati
Published: June 2022

Penelitian ini diawali dengan kondisi realita kinerja guru yang berdasarkan hasil capaian kerja dan wilayah masih tergolong dalam kategori cukup yang artinya diperlukan peningkatan agar lebih baik dari sebelumnya. Tujuan penelitian ini ialah menganalisis kinerja guru yang dipengaruhi oleh gaya kepemimpinan transformasional, motivasi kerja, dan disiplin kerja pada guru dengan studi kasus Guru Akuntansi Kejuruan Bisnis dan Manajemen SMK di Jakarta Pusat. Pendekatan yang digunakan yaitu kuantitatif dengan metode survey. Pengumpulan data menggunakan kuesioner dengan skala likert dan juga data sekunder dari Penilaian Kinerja Guru. Sampel yang digunakan sebanyak 65 guru dengan teknik sampel proportionate random sampling. Data penelitian dianalisis dengan SPSS versi 24. Hasil penelitian menunjukkan bahwa gaya kepemimpinan transformasional, motivasi kerja, dan disiplin kerja kerja berpengaruh positif dan signifikan terhadap kinerja guru baik secara parsial maupun stimultan dengan kontribusi sebesar 46,1%. Penelitian ini berkontribusi terhadap pembuktian secara empiris mengenai pengaruh gaya kepemimpinan transformasional, motivasi kerja, dan disiplin kerja kerja terhadap kinerja guru.Keywords: Kinerja, Kepemimpinan Transformasional, Motivasi, Disiplin
PENGARUH INTELLECTUAL CAPITAL, INTELLECTUAL CAPITAL DISCLOSURE (ICD) TERHADAP NILAI PERUSAHAAN DENGAN PROFITABILITAS SEBAGAI VARIABEL INTERVENING
Authors: Claudia Vrilly , Gustiawaty Fajar , Joko Tri
Published: June 2022

Penelitian ini bertujuan untuk menguji pengaruh modal intelektual (IC), pengungkapan modal intelektual (ICD) terhadap nilai perusahaan dengan profitabilitas sebagai variabel intervening.Dalam penelitian ini metode pengambilan sampel menggunakan purposive sampling dan diperoleh sebanyak 25 perusahaan LQ-45 yang terdaftar di BEI selama tahun 2016-2018, Data yang ada dianalisis dengan menggunakan The Partial Least Square (SmartPLS) 3.Hasil penelitian menunjukkan bahwa IC positif signifikan terhadap profitabilitas; ICD berpengaruh positif signifikan terhadap profitabilitas; IC memiliki pengaruh positif tetapi tidak signifikan terhadap nilai perusahaan; ICD negatif nilai perusahaan; profitabilitas berpengaruh positif signifikan terhadap nilai perusahaan; IC berpengaruh positif signifikan terhadap nilai perusahaan yang dimediasi oleh profitabilitas dan ICD positif signifikan terhadap nilai perusahaan yang dimediasi oleh profitabilitas.
PENGARUH KEMAMPUAN TECHNOLOGICAL PEDAGOGICAL CONTENT KNOWLEDGE (TPACK) TERHADAP KESIAPAN MENJADI GURU
Authors: Perdani Berliana Ucha Maulid , Andayani Endang Sri
Published: June 2022

Guru merupakan salah satu pihak yang berperan untuk mewujudkan pendidikan yang berkualitas. Oleh karena itu kualitas guru sangat menentukan kualitas pelaksanaan pembelajaran di sekolah. Perguruaan tinggi memiliki peran yang besar dalam memberikan bekal berbagai kompetensi kepada para calon guru untuk dapat memasuki dunia kerja. Dengan kompetensi yang cukup, calon guru akan lebih siap memasuki dunia sekolah. Penelitian ini bertujuan untuk menganalisis pengaruh kemampuan teknologi, kemampuan pedagogik, dan pengetahuan bidang akuntansi terhadap kesiapan mahasiswa menjadi guru. Penelitian ini menggunakan pendekatan kuantitatif dengan metode eksplanasi. Responden penelitian berjumlah 211 mahasiswa pendidikan akuntansi Universitas Negeri Malang. Teknik pengambilan sampel menggunakan proportional stratified random sampling. Teknik pengumpulan data menggunakan kuesioner yang disebarkan secara online kemudian dianalisis menggunakan regresi linier berganda. Hasil penelitian menunjukkan bahwa kemampuan teknologi, kemampuan pedagogik, dan pengetahuan bidang akuntansi berpengaruh positif signifikan terhadap kesiapan mahasiswa menjadi guru. Artinya semakin baik kemampuan teknologi, kemampuan pedagogik, dan pengetahuan bidang akuntansi mahasiswa calon guru membuat kesiapan mahasiswa untuk menjadi guru semakin baik. Oleh karena itu penelitian ini diharapkan mampu menjadi bahan literature dan wawasan bagi mahasiswa mengenai kemampuan TPACK terhadap kesiapan untuk menjadi guru.
ENHANCED CIRCULATORY LEVELS OF OSTEOPROTEGERIN IN TYPE 2 DIABETES MELLITUS PATIENTS: ASSOCIATION WITH METABOLIC AND HORMONAL DYSBALANCE PARAMETERS, VASCULAR COMPLICATIONS PATTERN
Authors: Gorshunska Maryana
Published: June 2022

61 middle-age overweight or obese patients with type 2 diabetes mellitus were studied. Patients were characterized by hormonal and metabolic parameters of insulin resistance (fasting hyperinsulinemia, both enhanced HOMA-IR indices and circulating free fatty acids levels, hypoadiponectinemia, hypertriglyceridemia). It was revealed significant increase in the circulating levels of osteoprotegerin, associated with macrovascular complications (ischemic heart disease, essential hypertension). It was also shown positive correlation of osteoprotegerin with retinol-binding protein 4, fetuin-A and progranulin. Our data support the perspective of circulating osteoprotegerin as new cardiovascular risk factor.
METFORMIN - THE FIRST STEP IN THE TREATMENT OF TYPE 2 DIABETES MELLITUS
Authors: Kravchun N. O.
Published: June 2022

To date, the preparations of choices in the treatment of diabetes (SD) 2 types are biguenides. Metformin is the only representative of this group of drugs, which is recommended as starting therapy of SD 2 type by the joint consensus of American (ADA) and European (EASD) international associations for the treatment of CDs. Regardless of the variant of the intensification of drug therapy,
CARDIOVASCULAR AUTONOMIC NEUROPATHY IN TYPE 2 DIABETES MELLITUS: ASSOCIATION BETWEEN SPATIAL QRS-T ANGLE WITH FUNCTIONAL AND STRUCTURAL MYOCARDIUM DISORDERS
Authors: Serhiyenko V. A.
Published: June 2022

It was established, that the increase of the spatial QRS-T angle in patients with Type 2 diabetes mellitus without diagnosed CVD may indicate a presence of subclinical CAN, which often can not be diagnosed using traditional diagnostic methods. Increased parameters of spatial QRS-T angle are correlated with the presence and/or progression of CAN; statistically significantly and independently correlated with prolongation and dispersion of QT interval. Increase of the spatial QRS-T angle is statistically significantly and independently associated with increasing of the left ventricular mass in patients with Type 2 diabetes mellitus. The results suggest the presence of pathophysiological links between the structural, functional and electro-mechanical disturbances in patients with Type 2 diabetes mellitus and CAN.
THE VIOLATION OF THE SERTOLI’S AND LEIDIG’S CELLS ULTRASTRUCTURE UNDER THE SEROTONIN HYDROCHLORIDE INFLUENCE
Authors: Brechka Nataliia , Nevzorov V. P. , Koreneva Yevheniia , Malova Nataliya , Richkova S. S. , Ivannicova S. V. , Boyko Maryna
Published: June 2022

The peculiarities of the Sertoli’s and Leidig’s cells ultrastructure changes that are playing main role in the spermatogenesis violations owing to serotonin hydrochloride destructive affect has been studied. It has been determined that serotonin hydrochloride subcutaneous introduction in dose of 5 mg/kg during 14 days led to Sertoli’s and Leidig’s rats cells ultrastructure violations. The basis of these violations should be considered to be the mitochondrial crists and diaphragmatic destruction. Those changes lead to the power supply deficiency of the synthetic and reparative intracellular processes. Serotonin hydrochloride disturbs the metabolism of the rat’s testicles supporting epitheliocytes and endocrinocytes. The synthetic and reparative activities are dramatically decreased, that is structurally confirmed by fragmentation of the endoplasmic system diaphragms, by decreasing of the ribosome’s, polysome’s and secretory granules amount, by increasing of the secondary lisosome’s amount and by reduction of Goldgi’s cytoplasic complex.
PREVALENCE AND STRUCTURE OF DYSLIPIDEMIA IN CHILDREN AND ADOLESCENTS WITH OBESITY AND OVERWEIGHT
Authors: Shlyakhova N. V. , Budreiko O. A.
Published: June 2022

The study of lipid profile of blood in 244 children aged 6–17 years with obesity and overweightshowed a high prevalence of dyslipidemia in these patients (60,7 %), especially with against prolongedduration of obesity (75,9 %) and early puberty (72,9 %). It has been determined that lipid profileviolations occur half as likely in children with overweight (36,7 %) that in those with obesity (66,7 %),regardless of its degree and sex of patients. Dominating in dyslipidemia structure obese children,regardless of sex, are a decrease in high density lipoprotein, elevated levels of total cholesterol andlow density lipoprotein, mainly in the form of combined changes in these indicators.
CLINICAL PECULIARITIES OF TEENAGER BOYS OBESITY SUBJECT TO UNFAVOURABLE PERINATAL FACTORS
Authors: Cherevko I. G.
Published: June 2022

Clinical examination of 369 obese boys of age 10–17 revealed that the majority of overweightpatients noted a number of complaints, among which the most common were headache, increasedappetite, thirst, decreased performance and progress at school. The following clinical features at ashort enough anamnesis were typical for boys in their early puberty: accelerated puberty, increasedblood pressure, diffuse goiter of the 1st dg, striae on the skin. Against the background of diseasemanifestation among adolescents we observe increased rate of abdominal obesity, hypertension,accelerated puberty, diffuse goiter 1st and 2nd dg. The combination of such symptoms as abdominalobesity and hypertension as components of the metabolic syndrome provides a basis for a moredetailed examination of this group of patients.
THE INFLUENCE OF THE CHONDROITINE SULPHATE ON THE SERTOLI AND LEYDIG CELLS ULTRASTRUCTURE
Authors: Brechka Nataliia
Published: June 2022

The peculiarities of the Sertoli and Leydig cells ultrastructure testis of rats under inﬂuenceof the chondroitine sulphate after destructive inﬂuence of the serotonin hydrochloride have beenstudied. It determined that chondroitine sulphate furthers to retrieve of the typical architectonics ofthe testis of rats Sertoli and Leydig cells have been undergone of destructive impact of serotoninhydrochloride. Chondroitine sulphate furthers to normalization of submicroscopic mitochondrialorganization manifesting by absence of the lysis areas of the external membranes and crysts andby appearance of the dividing forms. The adequate cells bioenergy consumption is renewing. TheSertoli and Leydig cells bioenergy correction under the inﬂuence of chondroitine sulphate lead toactivation of the synthetic processes and to the reparation of intracellular structure.
OXIDATIVE STERSS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS: RELATION TO CHARACTERISTICS OF THE DEVELOPMENT, PROGRESSION AND COMPLICATIONS (Review and our own results)
Authors: Gorshunska Maryana
Published: June 2022

Review is devoted to the role of oxidative stress in the pathogenesis of type 2 diabetes mellitusand its vascular complications. We present multiple correlations of indicators that comprehensivelycharacterize oxidative stress, with classic and novel parameters of insulin resistance, dyslipidemia,and chronic inflammation in patients with type 2 diabetes mellitus.
CARDIO- AND NEUROPROTECTION IN AUTONOMOUS HEART NEUROPATHY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS (literature review and own data)
Authors: Sergienko V. O.
Published: June 2022

There are two main forms of damage myocardium in diabetes mellitus: diabetychna kardiomiopatiya (Non-Coronary genesis i (ishemic). Vydilyayut, metabolic or metabolic-hipoksychnu stage, which is of specific metabolic disease MC belonging to the secondary metabolic endocrine kardiopatiy, metabolic-ishemichnu stage, infarkt miokarda, dystrophic koronarosklerotychnyy kardioskleroz; diabetychnu autonomous nevropatiyu heart DANS is one of the most serious complications of diabetes, which is diagnosed poorly,

may be accompanied by severe postural hypotension, impaired exercise tolerance, be the cause of coronary ischemia, "dumb" MI,

syndrome of "sudden" death.
Effects and Processes of an mHealth Intervention for the Management of Chronic Diseases: Prospective Observational Study
Authors: Breckner Amanda , Litke Nicola , Göbl Linda , Wiezorreck Lars , Miksch Antje , Szecsenyi Joachim , Wensing Michel , Weis Aline
Published: June 2022

Background

Mobile health (mHealth) interventions for self-management are a promising way to meet the needs of patients with chronic diseases in primary care practices. Therefore, an mHealth intervention, TelePraCMan, was developed and evaluated for patients with type 2 diabetes mellitus, chronic obstructive pulmonary disease, high blood pressure, or heart failure in a German primary care setting. TelePraCMan entails a symptom diary, an appointment manager, a manager to document goals, and a warning system. The app should foster the self-management of participating patients.

Objective

We aimed to examine the effects of TelePraCMan on patient activation and quality of life and explored the underlying contextual factors, impacts, and degree of implementation.

Methods

In a prospective observational study design, we collected data by using interviews and written questionnaires from participating patients (intervention and control groups) and primary care workers (physicians and practice assistants). The primary outcomes of interest were patient-reported quality of life (12-Item Short Form Survey) and patient activation (patient activation measure). The quantitative analysis focused on differences between patients in the intervention and control groups, as well as before (T0) and after (T1) the intervention. Interviews were analyzed by using qualitative content analysis via MAXQDA (VERBI GmbH).

Results

At baseline, 25 patients and 24 primary care workers completed the questionnaire, and 18 patients and 21 primary care workers completed the follow-up survey. The patients were predominantly male and, on average, aged 64 (SD 11) years (T0). The primary care workers were mostly female (62%) and, on average, aged 47 (SD 10) years (T0). No differences were observed in the outcomes before and after the intervention or between the intervention and control groups. In the additional interviews, 4 patients and 11 primary care workers were included. The interviewees perceived that the intervention was useful for some patients. However, contextual factors and problems with implementation activities negatively affected the use of the app with patients. The main reasons for the low participation were the COVID-19 pandemic and the target group, which seemed to have less interest in mHealth; the interviewees attributed this to the older age of patients. However, the respondents felt that the app would be better accepted in 5 or 10 years.

Conclusions

Although the TelePraCMan app was rated as very good and important by the participants, few patients used it. The digital intervention was hardly implemented and had limited impact in the current setting of German primary care.

Trial Registration

German Clinical Trials Register DRKS00017320; https://tinyurl.com/4uwrzu85
Measurement of Vital Signs Using Lifelight Remote Photoplethysmography: Results of the VISION-D and VISION-V Observational Studies
Authors: Heiden Emily , Jones Tom , Brogaard Maczka Annika , Kapoor Melissa , Chauhan Milan , Wiffen Laura , Barham Helen , Holland Jeremy , Saxena Manish , Wegerif Simon , Brown Thomas , Lomax Mitch , Massey Heather , Rostami Shahin , Pearce Laurence , Chauhan Anoop
Published: June 2022

Background

The detection of early changes in vital signs (VSs) enables timely intervention; however, the measurement of VSs requires hands-on technical expertise and is often time-consuming. The contactless measurement of VSs is beneficial to prevent infection, such as during the COVID-19 pandemic. Lifelight is a novel software being developed to measure VSs by remote photoplethysmography based on video captures of the face via the integral camera on mobile phones and tablets. We report two early studies in the development of Lifelight.

Objective

The objective of the Vital Sign Comparison Between Lifelight and Standard of Care: Development (VISION-D) study (NCT04763746) was to measure respiratory rate (RR), pulse rate (PR), and blood pressure (BP) simultaneously by using the current standard of care manual methods and the Lifelight software to iteratively refine the software algorithms. The objective of the Vital Sign Comparison Between Lifelight and Standard of Care: Validation (VISION-V) study (NCT03998098) was to validate the use of Lifelight software to accurately measure VSs.

Methods

BP, PR, and RR were measured simultaneously using Lifelight, a sphygmomanometer (BP and PR), and the manual counting of RR. Accuracy performance targets for each VS were defined from a systematic literature review of the performance of state-of-the-art VSs technologies.

Results

The VISION-D data set (17,233 measurements from 8585 participants) met the accuracy targets for RR (mean error 0.3, SD 3.6 vs target mean error 2.3, SD 5.0; n=7462), PR (mean error 0.3, SD 4.0 vs mean error 2.2, SD 9.2; n=10,214), and diastolic BP (mean error −0.4, SD 8.5 vs mean error 5.5, SD 8.9; n=8951); for systolic BP, the mean error target was met but not the SD (mean error 3.5, SD 16.8 vs mean error 6.7, SD 15.3; n=9233). Fitzpatrick skin type did not affect accuracy. The VISION-V data set (679 measurements from 127 participants) met all the standards: mean error −0.1, SD 3.4 for RR; mean error 1.4, SD 3.8 for PR; mean error 2.8, SD 14.5 for systolic BP; and mean error −0.3, SD 7.0 for diastolic BP.

Conclusions

At this early stage in development, Lifelight demonstrates sufficient accuracy in the measurement of VSs to support certification for a Level 1 Conformité Européenne mark. As the use of Lifelight does not require specific training or equipment, the software is potentially useful for the contactless measurement of VSs by nonclinical staff in residential and home care settings. Work is continuing to enhance data collection and processing to achieve the robustness and accuracy required for routine clinical use.

International Registered Report Identifier (IRRID)

RR2-10.2196/14326
Determining the Influencing Factors on Acceptance of eHealth Pain Management Interventions Among Patients With Chronic Pain Using the Unified Theory of Acceptance and Use of Technology: Cross-sectional Study
Authors: Stoppok Paula , Teufel Martin , Jahre Lisa , Rometsch Caroline , Müßgens Diana , Bingel Ulrike , Skoda Eva-Maria , Bäuerle Alexander
Published: June 2022

Background

Chronic pain is a complex disease with high prevalence rates, and many individuals who are affected do not receive adequate treatment. As a complement to conventional therapies, eHealth interventions could provide many benefits to a multimodal treatment approach for patients with chronic pain, whereby future use is associated with the acceptance of these interventions.

Objective

This study aims to assess the acceptance of eHealth pain management interventions among patients with chronic pain and identify the influencing factors on acceptance. A further objective of the study is to evaluate the viability of the Unified Theory of Acceptance and Use of Technology (UTAUT) model and compare it with its extended version in terms of explained variance of acceptance.

Methods

We performed a cross-sectional web-based study. In total, 307 participants with chronic pain, as defined according to the International Association for the Study of Pain criteria, were recruited through flyers, posters, and web-based inquiries between December 2020 and July 2021. In addition to sociodemographic and medical data, the assessment included validated psychometric instruments and an extended version of the well-established UTAUT model. For statistical analyses, group comparisons and multiple hierarchical regression analyses were performed.

Results

The acceptance of eHealth pain management interventions among patients with chronic pain was overall moderate to high (mean 3.67, SD 0.89). There was significant difference in acceptance among age groups (W=9674.0; r=0.156; P=.04). Effort expectancy (β=.37; P<.001), performance expectancy (β=.33; P<.001), and social influence (β=.34; P<.001) proved to be the most important predictors of acceptance. The extended UTAUT (including the original UTAUT factors as well as sociodemographic, medical, and eHealth-related factors) model explained 66.4% of the variance in acceptance, thus supporting the viability of the model. Compared with the original UTAUT model (performance expectancy, effort expectancy, and social influence), the extended model explained significantly more variance (F25,278=1.74; P=.02).

Conclusions

Given the association between acceptance and future use, the knowledge of the influencing factors on acceptance should be used in the development and promotion of eHealth pain management interventions. Overall, the acceptance of eHealth pain management interventions was moderate to high. In total, 8 predictors proved to be significant predictors of acceptance. The UTAUT model is a valuable instrument for determining acceptance as well as the factors that influence acceptance of eHealth pain management interventions among patients with chronic pain. The extended UTAUT model provided the greatest predictive value for acceptance.
Instructor Development Workshops for Advanced Life Support Training Courses Held in a Fully Virtual Space: Observational Study
Authors: Kiyozumi Tetsuro , Ishigami Norio , Tatsushima Daisuke , Araki Yoshiyuki , Yoshimura Yuya , Saitoh Daizoh
Published: June 2022

Background

Various face-to-face training opportunities have been lost due to the COVID-19 pandemic. Instructor development workshops for advanced resuscitation (ie, advanced life support) training courses are no exception. Virtual reality (VR) is an attractive strategy for remote training. However, to our knowledge, there are no reports of resuscitation instructor training programs being held in a virtual space.

Objective

This study aimed to investigate the learning effects of an instructor development workshop that was conducted in a virtual space.

Methods

In this observational study, we created a virtual workshop space by using NEUTRANS (Synamon Inc)—a commercial VR collaboration service. The instructor development workshop for the advanced life support training course was held in a virtual space (ie, termed the VR course) as a certified workshop by the Japanese Association of Acute Medicine. We asked 13 instructor candidates (students) who participated in the VR course to provide a workshop report (VR group). Reports from a previously held face-to-face workshop (ie, the face-to-face course and group) were likewise prepared for comparison. A total of 5 certified instructor trainers viewed and scored the reports on a 5-point Likert scale.

Results

All students completed the VR course without any problems and received certificates of completion. The scores for the VR group and the face-to-face group did not differ at the level of statistical significance (median 3.8, IQR 3.8-4.0 and median 4.2, IQR 3.9-4.2, respectively; P=.41).

Conclusions

We successfully conducted an instructor development workshop in a virtual space. The degree of learning in the virtual workshop was the same as that in the face-to-face workshop.
Звернення головного редактора
Authors: Nikonov V.V.
Published: June 2022

No abstract
Тромбоемболічні ускладнення у хворих з гострою хірургічною патологією при коронaвірусній інфекції COVID-19
Authors: Boyko V.V. , Likhman V.M. , Shevchenko O.M. , Tkachuk O.Y. , Merkulov A.O. , Belodyd E.O. , Ponomarova K.V.
Published: June 2022

Актуальність. Захворювання, що викликається коронавірусом SARS-CoV-2 і отримало назву COVID-19, характеризується частим поєднанням респіраторних порушень з коагулопатіями. Тромбоемболічні ускладнення у цій категорії пацієнтів — одна з причин, яка визначає тяжкість стану та ймовірність летального результату. При COVID-19 порушення гемостазу варіює у широких межах: від латентної гіперкоагуляції до тяжких клінічних проявів у вигляді церебрального або коронарного артеріального тромбозу або венозного тромбозу, ускладненого тромбоемболією легеневої артерії, а також синдромом дисемінового внутрішньосудинного згортання. Мета дослідження: вивчення клінічних проявів порушень гемостазу за даними лабораторних досліджень. Матеріали та методи. У ДУ «Інститут загальної та невідкладної хірургії ім. В.Т. Зайцева НАМН України» за період з січня по вересень 2021 року спостерігали 96 пацієнтів з гострою хірургічною патологією, з позитивним ПЛР-тестом на COVID-19. У 28 (29,1 %) хворих у процесі лікування було діагностовано артеріальні та венозні тромбози. Ці хворі були включені в основну групу дослідження. Наявність вірусу було підтверджено результатами лабораторних досліджень (ПЛР) у 74 пацієнтів (77,1 %). Результати. Частіше у хворих на гостру хірургічну патологію з COVID-19 реєструється тромбоз поверхневих вен верхніх кінцівок, що виражається як посткатетерний тромбофлебіт. За частотою таких станів, як локальний тромбоз устя внутрішньої сонної артерії, статистично значущих відмінностей отримано не було. Це ще раз свідчить про необхідність обстеження всіх пацієнтів з COVID-19 на наявність можливих тромботичних ускладнень, незалежно від клінічних проявів. Висновки. Частота виникнення тромбоемболічних ускладнень потребує розробки ефективних превентивних протоколів. Специфічна коагулопатія та тромбоемболічні ускладнення у період пандемії COVID-19 набули особливої актуальності як одні з ключових чинників тяжкого перебігу та несприятливого прогнозу у хворих.
The Brazilian criminal recidivism: Reflections under the perspective of the comparative law
Authors: Martins Lisandra Moreira , Arruda Eloísa de Sousa , Santana Isael José
Published: June 2022

The criminal recidivism, aggravating circumstance of the penalty, is one of the oldest institutes of the Brazilian legal order and, although the uncounted reforms on criminal and criminal procedural law in the course of history, it has suffered very few changes, predominating the automatic imposition in miscellaneous process stages under the justification of crime fighting, without a detailed analysis about the modus operandi, the real objectives and elements. Thus, the following study aims to address the thematic from the study of comparative law in order to demonstrate how the criminal recidivism is applied on the selected countries in this opportunity, what demonstrates several ways to ponder this penalty aggravating, that must be compatible with the respect to the democratic essence of the criminal procedural law, especially the Brazilian one, based on the prevalence of the fundamental rights and guarantees.