bluuebunny/crossref_metadata_2025 huggingface dataset:
Research on the Tectonic Characteristics and Hydrocarbon Prospects in the Northern Area of the South Yellow Sea Based on Gravity and Magnetic Data
Authors: Xu Wenqiang , Yao Changli , Yuan Bingqiang , An Shaole , Yin Xianzhe , Yuan Xiaoyu
Published: July 2023

To further explore the geological structure and the Mesozoic–Paleozoic hydrocarbon prospects in the northern area of the South Yellow Sea (SYS), multiple geological and geophysical data were systematically gathered and compiled, including gravity and magnetic data, seismic surveys, drilling data, and previous research results. The characteristics and genesis of the gravity and magnetic anomalies are examined. This study employs residual gravity anomalies and multiple edge detection methods to identify fault lineament structures and assess the tectonic framework. Moreover, the study utilizes 2.5D gravity-seismic joint modellings and regression analysis to estimate the basement depth. Additionally, the study examines the basement characteristics and discusses the thickness of the Mesozoic–Paleozoic strata. Finally, the study further identifies prospects for hydrocarbons in the Mesozoic–Paleozoic. Our findings show that the faults are incredibly abundant and that the intensity of fault activity weakens gradually from NW to SE. Specifically, NE (NEE) trending faults are interlaced and cut off by NW (NWW), near-EW, and near-SN trending secondary faults, which form an en-echelon composite faults system with a dominant NE (NEE) orientation. Thick Mesozoic–Paleozoic strata are preserved, but we observe distinct variations in basement characteristics and the pre-Cenozoic structural deformation along the N-S direction. Therefore, the Northern Basin of SYS (NBSYS) and the Middle Uplift of SYS (MUSYS) are characterized by alternating sags and bulges in the S-N direction and in the E-W direction, respectively, forming a chessboard tectonic framework. Considering the oil and gas accumulation model, we identify three target hydrocarbon prospects in the NBSYS and two favorable hydrocarbon prospects in the MUSYS.
New Evaluation Method of Exposure to Radon Gas in Mining Environments
Authors: Francisca Diego , Iramina Wilson , Ayres da Silva Anna , de Tomi Giorgio
Published: July 2023

Physical and chemical agents in workplace environments can be hazardous for employees. Much of the exposure to ionizing radiation can occur due to the presence of radon in the workplace. Mining environments are more susceptible to containing radon gas because it emanates from soil or rocks. Radon is known to be associated with lung cancer as it is a gaseous chemical agent under normal conditions and is also radioactive. Since there is little knowledge about radon in Brazilian mining workplaces, this study aims to measure occupational exposure to radon in mining environments through a proposed methodology and to verify its compliance with international standards to confirm the potential risk of exposure for employees. Radon concentration in open-pit mining work environments was measured and used as a basis for comparison to assess the proposed new evaluation method, which will consist of laboratory evaluations of samples taken from the same workplaces. The radon concentration data in the work environments were compared to laboratory tests for statistical correlation. The results, compared to reference values, tolerance limits, and action levels, showed that radon, in outdoor mining workplaces, can be considered a low risk to employees’ health. The application of the methodology also indicated that the laboratory tests and the field evaluations presented a statistical correlation with each other, being an indication that the laboratory tests can be used to estimate the risks in a preliminary way. Another important point is the fact that it was observed that measurements in the laboratory were more practical and faster to perform when compared to field evaluations. These facts can bring future gains in the number of tests performed and workplace evaluated in mining environments.
Water–Rock Interactions Driving Groundwater Composition in the Pra Basin (Ghana) Identified by Combinatorial Inverse Geochemical Modelling
Authors: Manu Evans , De Lucia Marco , Kühn Michael
Published: July 2023

The crystalline basement aquifer of the Pra Basin in Ghana is essential to the water supply systems of the region. This region is experiencing the ongoing pollution of major river networks from illegal mining activities. Water management is difficult due to the limited knowledge of hydrochemical controls on the groundwater. This study investigates its evolution based on analyses from a previous groundwater sampling campaign and mineralogical investigation of outcrops. The dominant reactions driving the average groundwater composition were identified by means of a combinatorial inverse modelling approach under the hypothesis of local thermodynamical equilibrium. The weathering of silicate minerals, including albite, anorthite, plagioclase, K-feldspar, and chalcedony, explains the observed median groundwater composition in the transition and discharge zones. Additional site-specific hypotheses were needed to match the observed composition of the main recharge area, including equilibration with carbon dioxide, kaolinite, and hematite in the soil and unsaturated zones, respectively, and the degradation of organic matter controlling the sulfate/sulfide content, thus pointing towards kinetic effects during water–rock interactions in this zone. Even though an averaged water composition was used, the inverse models can “bridge” the knowledge gap on the large basin scale to come up with quite distinct “best” mineral assemblages that explain observed field conditions. This study provides a conceptual framework of the hydrogeochemical evolution for managing groundwater resources in the Pra Basin and presents modelling techniques that can be applied to similar regions with comparable levels of heterogeneity in water chemistry and limited knowledge of aquifer mineralogy. The combinatorial inverse model approach offers enhanced flexibility by systematically generating all plausible combinations of mineral assemblages from a given pool of mineral phases, thereby allowing for a comprehensive exploration of the reactions driving the chemical evolution of the groundwater.
First Occurrence of Titanian Hydroxylclinohumite in Marble-Hosting Gem Spinel Deposits, Luc Yen, Vietnam
Authors: Krivovichev Vladimir G. , Kuksa Katherine A. , Sokolov Pavel B. , Panikorovskii Taras L. , Bocharov Vladimir N. , Gussiås Geir Atle
Published: July 2023

In this paper, we report the very first occurrence of titanian hydroxylclinohumite in the marble-hosted gem spinel deposits of the Luc Yen district, northern Vietnam. Hydroxylclinohumite is anhedral and associated with forsterite, tremolite, pargasite, diopside, spinel, dolomite and calcite. Hydroxylclinohumite from the Luc Yen deposit was characterized via electron microprobe analysis, single-crystal X-ray diffraction study, and Raman spectrometry. The average composition is (Mg0.69Ti0.29Fe0.02)Σ1.00Mg7.91(SiO4)4.08[(OH)1.10F0.53O0.37]Σ2.00. (ideally (Mg0.7Ti0.3)Σ1Mg8.0(SiO4)4[(OH)1.2F0.5O0.3]2). The compositions of the analyzed hydroxylclinohumites have a narrow range of Mg/(Mg+Fe+Ti) values (0.96–0.97) and a defined hydroxylclinohumite solid-solution series. Compared with other occurrences, the Luc Yen hydroxylclinohumite has an average titanium content, which attains 0.31 atoms per formula unit (3.93 wt.% TiO2) and a low iron content of 0.04 atoms per formula unit (0.42 wt.% FeO). The formation of hydroxylclinohumite is favored by the proportion of Mg, and Si in the precursor rocks and the increased activity of H2O in the fluid phase.
Apriori Algorithm-Based Three-Dimensional Mineral Prospectivity Mapping—An Example from Meiling South Area, Xinjiang, China
Authors: Chang Jinyu , Zhang Nannan , Zhou Kefa , Tao Jintao , Chen Li , Zhang Hao , Chi Yujin
Published: July 2023

Mineral Prospectivity Mapping (MPM) is shifting toward intelligent deep mineralization searches in the era of big data and the increasing difficulties of surface deposit detection. Comparative analysis of two forms of mineralization prediction based on the Apriori algorithm was performed in the Meiling South mining area in the eastern Hami region of Xinjiang, China. In comparison 1, we use the Apriori algorithm to mine ore-forming information and determine the ore-forming voxel positions based on spatial distance and angle analysis. Then, we compare the ore-forming voxel positions determined by Apriori with the ore-forming voxel positions predicted by the mathematical model based on the conceptual model of mineralization, and these mathematical models include Gaussian Naive Bayesian (GNB) and Support Vector Machine (SVM). In comparison 2, the optimal prediction model is SVM, which is trained using the elements of mineralization prediction determined by the conceptual model of mineralization. Then, two sets of new elements of mineralization prediction are extracted from the original elements of mineralization prediction using the Apriori and Chi-square methods and then input into the SVM model for training. After we obtain the mineralization prediction results, we compare them with the original mineralization prediction results. The preceding comparison produced the following results. (1) Using the Apriori algorithm, the distribution characteristics of the high and low-grade ore bodies and the association rules between ore-bearing information were determined. (2) The prediction results of the GNB and SVM models displayed corresponding trends on the high and low-grade ore-bearing voxels identified by Apriori, which matched the rules mined by Apriori. (3) In comparison to the mineralization prediction elements screened by Chi-square and the original mineralization prediction elements based on the conceptual model of mineralization, the elements of mineralization prediction chosen based on Apriori have the best prediction effect in SVM when tested in new drill holes. Based on the mineralization prediction elements screened by Apriori, the number of accurate ore-bearing voxels (prediction probability greater than 0.5) predicted by the SVM model is 6, 5, and 1 in drill holes V1, V2, and V3, respectively. The collective results demonstrated that Apriori is explicit, intuitive, and interpretable for mineralization prediction and has a certain reference value for refining the determination of mineralization prediction elements and discovering mineralization mechanisms and laws.
Coexistence of Bloch and Parametric Mechanisms of High-Frequency Gain in Doped Superlattices
Authors: Čižas Vladislovas , Alexeeva Natalia , Alekseev Kirill N. , Valušis Gintaras
Published: July 2023

The detailed theoretical study of high-frequency signal gain, when a probe microwave signal is comparable to the AC pump electric field in a semiconductor superlattice, is presented. We identified conditions under which a doped superlattice biased by both DC and AC fields can generate or amplify high-frequency radiation composed of harmonics, half-harmonics, and fractional harmonics. Physical mechanisms behind the effects are discussed. It is revealed that in a general case, the amplification mechanism in superlattices is determined by the coexistence of both the phase-independent Bloch and phase-dependent parametric gain mechanisms. The interplay and contribution of these gain mechanisms can be adjusted by the sweeping AC pump strength and leveraging a proper phase between the pump and strong probe electric fields. Notably, a transition from the Bloch gain to the parametric gain, often naturally occurring as the amplitude of the amplified signal field grows, can facilitate an effective method of fractional harmonic generation in DC–AC-driven superlattices. The study also uncovers that the pure parametric generation of the fractional harmonics can be initiated via their ignition by switching the DC pump electric field. The findings open a promising avenue for the advancement of new miniature GHz–THz frequency generators, amplifiers, and dividers operating at room temperature.
Synthesis of Platinum Nanoparticles Supported on Fused Nanosized Carbon Spheres Derived from Sustainable Source for Application in a Hydrogen Generation Reaction
Authors: Biehler Erik , Quach Qui , Abdel-Fattah Tarek M.
Published: July 2023

The dwindling supply of fossil fuels has prompted the search for an alternative energy source that could effectively replace them. Potential renewable energy sources such as solar, wind, tidal, and geothermal are all promising but each has its own drawbacks. Hydrogen gas on the other hand can be combusted to produce energy with only water as a byproduct and can be steadily generated via the aqueous media hydrolysis reaction of Sodium Borohydride (NaBH4). This study successfully synthesized fused carbon spheres derived from sugar and decorated them with platinum nanoparticles to form a novel composite material (PtFCS) for catalyzing this reaction. The platinum nanoparticles were produced by reducing chloroplatinic acid in a solution with sodium borohydride and using sodium citrate as a capping agent for the nanoparticles. Transmission electron microscopy (TEM), Energy-dispersive X-ray spectroscopy (EDS), Fourier-transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD) were used to characterize and determine the size and shape of the Pt nanoparticles (PtNPs) and fused carbon spheres. TEM was able to determine the average size of the fused carbon spheres to be 200 nm and the average size for the PtNPs to be 2–3 nm. The PtFCS composite was tested for its ability to catalyze the hydrolysis of NaBH4 under various reaction conditions including various solution pH, various temperatures, and various dosages of sodium borohydride. The catalyst was found to perform the best under acidic solution conditions (pH 6), producing hydrogen at a rate of 0.0438 mL/mgcat·min. The catalyst was determined to have an activation energy of 53.0 kJ/mol and could be used multiple times in succession with no loss in the volume of hydrogen produced. This sugar-derived composite catalyst shows promise and could be implemented as a sustainable catalyst for the generation of hydrogen fuel.
Quantum-Dot-Induced Modification of Surface Functionalization for Active Applications of Whispering Gallery Mode Resonators
Authors: Brice Inga , Kim Vyacheslav V. , Ostrovskis Armands , Sedulis Arvids , Salgals Toms , Spolitis Sandis , Bobrovs Vjaceslavs , Alnis Janis , Ganeev Rashid A.
Published: July 2023

Quantum dots can modify the properties of the whispering gallery mode resonators (WGMRs) used in various potential applications. A deposition of a suitable nanomaterial for the surface functionalization of WGMRs allows for the achievement of high quality (Q) factors. Here, we show that the WGMR surface can be functionalized using quantum dots. We demonstrate that WGMRs covered with thin layers of HgS and PbS quantum dots are suitable for third-harmonic generation due to the high Q factor of the developed microresonators, thus significantly lowering the pumping power required for nonlinear optical interactions.
Heavy Metal and Rice in Gluten-Free Diets: Are They a Risk?
Authors: Bascuñán Karla A. , Orosteguí Claudia , Rodríguez Juan Manuel , Roncoroni Leda , Doneda Luisa , Elli Luca , Araya Magdalena
Published: July 2023

A gluten-free diet (GFD) is the treatment of choice for gluten-related disorders. It has been associated with macro- and micronutrient deficiencies. Recently, consumption of arsenic-contaminated rice has raised concern because of the potential greater risk that it may represent for people on GFDs, whose rice consumption is high, since it is a fundamental cereal in GFDs. We reviewed the data published over the last 20 years in Medline and Scielo, in English, French and Spanish, on four metals (As, Hg, Cd, and Pb), to assess whether the evidence suggests that celiac disease or consumption of a GFD is associated with increased levels of blood/urinary metal concentrations. The review revealed a few articles that were directly related to the four metals and their relationships with a GFD. The evidence supports that rice-based products are a relevant source of As and other metals. Clinical studies and evaluations based on NHANES have indicated that persons on GFDs have higher As and Hg blood/urinary levels, suggesting that the diet and not the disease is responsible for it. The levels described are statistically significant compared to those of persons on complete diets, but far from toxic levels. The question of whether higher exposure to heavy metals associated with a GFD is biologically relevant remains unanswered and deserves study.
Evaluating Bidirectional Predictive Pathways between Dietary Restraint and Food Addiction in Adolescents
Authors: Rios Julia M. , Berg Martha K. , Gearhardt Ashley N.
Published: July 2023

The relationship between food addiction, an important emerging construct of excessive eating pathology, and dietary restraint has yet to be fully understood. Eating disorder models commonly posit that dietary restraint exacerbates loss of control eating (e.g., binge episodes) and may also play a causal role in the development of food addiction. However, dietary restraint as a reaction to consequences of food addiction (e.g., uncontrollable eating or weight gain) represents another plausible pathway. Existing studies indicate that the association between food addiction and dietary restraint may be more significant during adolescence than adulthood, but are limited by cross-sectional study designs. A longitudinal study using an adolescent sample is ideal for investigating potential pathways underlying links between food addiction and dietary restraint. This study examined temporal pathways between food addiction and dietary restraint in a sample of one hundred twenty-seven adolescents (M = 14.8, SD = 1.1) at three timepoints spanning two years. This is the first study to examine longitudinal cross-lagged panel associations between food addiction and dietary restraint. In this adolescent sample, food addiction significantly predicted future dietary restraint (b = 0.25, SE = 0.06, p < 0.001), but dietary restraint did not significantly predict future food addiction (b = 0.06, SE = 0.05, p > 0.05). These findings support the theory that dietary restraint may be a reaction to deleterious effects of food addiction during adolescence.
Association of Serum Vitamin B12 and Circulating Methylmalonic Acid Levels with All-Cause and Cardiovascular Disease Mortality among Individuals with Chronic Kidney Disease
Authors: Wu Shiyi , Chang Wenling , Xie Zhihao , Yao Boshuang , Wang Xiaoyu , Yang Chunxia
Published: July 2023

(1) Background: it is unclear whether serum vitamin B12 and circulating methylmalonic acid (MMA) are related with a poor prognosis among individuals with chronic kidney disease (CKD); (2) Methods: this prospective cohort study included 2589 individuals with CKD who participated in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2004, and from 2011 to 2014, respectively. Hazard ratios (HRs) and 95% Cis for the associations of MMA and vitamin B12 levels with the risk of all-cause and cardiovascular disease (CVD) mortality were calculated using multivariable Cox proportional hazards regression models. Restricted cubic spline analyses were used to examine the non-linear association of MMA levels with all-cause and CVD mortality. (3) Results: among the 2589 participants, we identified 1192 all-cause deaths and 446 CVD deaths, respectively, with a median follow-up of 7.7 years. Compared with participants with MMA < 123 nmol/L, those with MMA ≥ 240 nmol/L had an increased all-cause and CVD mortality in the multivariable-adjusted model [HR (95% CI), 2.01 (1.54–2.62) and 1.76 (1.18–2.63), respectively]; (4) Conclusions: higher circulating MMA levels were found to be strongly associated with an elevated all-cause and CVD mortality among individuals with CKD, while serum vitamin B12 levels were not associated.
NAD+ Precursors and Intestinal Inflammation: Therapeutic Insights Involving Gut Microbiota
Authors: Niño-Narvión Julia , Rojo-López Marina Idalia , Martinez-Santos Patricia , Rossell Joana , Ruiz-Alcaraz Antonio J. , Alonso Núria , Ramos-Molina Bruno , Mauricio Didac , Julve Josep
Published: July 2023

The oxidized form of nicotinamide adenine dinucleotide (NAD+) is a critical metabolite for living cells. NAD+ may act either as a cofactor for many cellular reactions as well as a coenzyme for different NAD+-consuming enzymes involved in the physiological homeostasis of different organs and systems. In mammals, NAD+ is synthesized from either tryptophan or other vitamin B3 intermediates that act as NAD+ precursors. Recent research suggests that NAD+ precursors play a crucial role in maintaining the integrity of the gut barrier. Indeed, its deficiency has been associated with enhanced gut inflammation and leakage, and dysbiosis. Conversely, NAD+-increasing therapies may confer protection against intestinal inflammation in experimental conditions and human patients, with accumulating evidence indicating that such favorable effects could be, at least in part, mediated by concomitant changes in the composition of intestinal microbiota. However, the mechanisms by which NAD+-based treatments affect the microbiota are still poorly understood. In this context, we have focused specifically on the impact of NAD+ deficiency on intestinal inflammation and dysbiosis in animal and human models. We have further explored the relationship between NAD+ and improved host intestinal metabolism and immunity and the composition of microbiota in vivo. Overall, this comprehensive review aims to provide a new perspective on the effect of NAD+-increasing strategies on host intestinal physiology.
The Effect of Very-Long-Chain n-3 Polyunsaturated Fatty Acids in the Central Nervous System and Their Potential Benefits for Treating Alcohol Use Disorder: Reviewing Pre-Clinical and Clinical Data
Authors: Carvajal Francisca , Sánchez-Gil Ainhoa , Cardona Diana , Rincón-Cervera Miguel Angel , Lerma-Cabrera Jose Manuel
Published: July 2023

Alcohol use poses a significant global health concern, leading to serious physical and socioeconomic issues worldwide. The current treatment options for problematic alcohol consumption are limited, leading to the exploration of alternative approaches, such as nutraceuticals. One promising target is very-long-chain n-3 polyunsaturated fatty acids (VLC n-3 PUFAs). This review aims to compile the most relevant pre-clinical and clinical evidence on the effect of VLC n-3 PUFAs on alcohol use disorders and related outcomes. The findings suggest that VLC n-3 PUFAs may alleviate the physiological changes induced by alcohol consumption, including neuroinflammation and neurotransmitter dysregulation. Additionally, they can reduce withdrawal symptoms, improve mood, and reduce stress level, all of which are closely associated with problematic alcohol consumption. However, more research is required to fully understand the precise mechanisms by which VLC n-3 PUFAs exert their function. Furthermore, PUFAs should not be considered a standalone solution, but as a complement to other therapeutic approaches. Although preliminary evidence supports the potential therapeutic effect of VLC n-3 PUFAs on problematic alcohol consumption, additional research is needed to validate these findings and determine the optimal use of PUFAs as part of a comprehensive approach to the treatment of alcohol use disorders.
Athletes with Eating Disorders: Analysis of Their Clinical Characteristics, Psychopathology and Response to Treatment
Authors: Ibáñez-Caparrós Ana , Sánchez Isabel , Granero Roser , Jiménez-Murcia Susana , Rosinska Magda , Thiel Ansgar , Zipfel Stephan , de Pablo Joan , Camacho-Barcia Lucia , Fernandez-Aranda Fernando
Published: July 2023

Eating disorders (ED) have frequently been described among athletes. However, their specific features and therapy responses are lacking in the literature. The aims of this article were to compare clinical, psychopathological and personality traits between ED patients who were professional athletes (ED-A) with those who were not (ED-NA) and to explore differences in response to treatment. The sample comprised n = 104 patients with ED (n = 52 ED-A and n = 52 matched ED-NA) diagnosed according to DSM-5 criteria. Evaluation consisted of a semi-structured face-to-face clinical interview conducted by expert clinicians and a psychometric battery. Treatment outcome was evaluated when the treatment program ended. ED-A patients showed less body dissatisfaction and psychological distress. No differences were found in treatment outcome among the groups. Within the ED-A group, those participants who performed individual sport activities and aesthetic sports presented higher eating psychopathology, more general psychopathology, differential personality traits and poor therapy outcome. Individual and aesthetic sports presented more severity and worse prognosis. Although usual treatment for ED might be similarly effective in ED-A and ED-NA, it might be important to develop preventive and early detection programs involving sports physicians and psychologists, coaches and family throughout the entire athletic career and afterwards.
Dihydro-Resveratrol Attenuates Oxidative Stress, Adipogenesis and Insulin Resistance in In Vitro Models and High-Fat Diet-Induced Mouse Model via AMPK Activation
Authors: Lam Chu-Shing , Xia Yi-Xuan , Chen Bai-Sen , Du Yin-Xiao , Liu Kang-Lun , Zhang Hong-Jie
Published: July 2023

Management of obesity has become a prevalent strategy for preventing the diseases closely integrated with excess body weight such as diabetes over the last half century. Searching for therapeutic agents acting on oxidative stress, adipogenesis and insulin resistance is considered as an efficient approach to control obesity-related diseases. The present study was designed to examine the in vitro and in vivo effects of dihydro-resveratrol (DR2), a naturally occurring compound from Dendrobium medicinal plants, on oxidative stress aggravation, adipogenesis, lipogenesis and insulin sensitivity. We utilized an in vitro 3T3-L1 adipocyte differentiation model to show that DR2 could reduce pre-adipocyte maturation by activation of AMPK/SIRT1 signaling proteins to inhibit p38MAPK proteins. With the use of in vitro oxidative-stress-induced hepatocytes and myoblasts models, DR2 was also shown to be able to reduce oxidative stress aggravation through mediation of Nrf2-related antioxidative cascade, reduce intracellular lipid accumulation through phosphorylation of ACC protein, reduce lipid peroxidation in hepatocytes and promote insulin sensitivity via activation of AKT protein in the insulin-resistant HepG2 cells and C2C12 cells. The effects of DR2 on adipogenesis, lipid accumulation, insulin resistance and blood glucose clearance were further demonstrated in the high-fat diet-induced obesity mouse model. Our in vitro and in vivo studies determined that DR2 could contain therapeutic potential for the treatment of obesity and type 2 diabetes.
Central Regulation of Eating Behaviors in Humans: Evidence from Functional Neuroimaging Studies
Authors: Chae Younbyoung , Lee In-Seon
Published: July 2023

Neuroimaging has great potential to provide insight into the neural response to food stimuli. Remarkable advances have been made in understanding the neural activity underlying food perception, not only in normal eating but also in obesity, eating disorders, and disorders of gut–brain interaction in recent decades. In addition to the abnormal brain function in patients with eating disorders compared to healthy controls, new therapies, such as neurofeedback and neurostimulation techniques, have been developed that target the malfunctioning brain regions in patients with eating disorders based on the results of neuroimaging studies. In this review, we present an overview of early and more recent research on the central processing and regulation of eating behavior in healthy and patient populations. In order to better understand the relationship between the gut and the brain as well as the neural mechanisms underlying abnormal ingestive behaviors, we also provide suggestions for future directions to enhance our current methods used in food-related neuroimaging studies.
Impact of Health Related QoL and Mediterranean Diet on Liver Fibrosis in Patients with NAFLD
Authors: Perez-Diaz-del-Campo Nuria , Castelnuovo Gabriele , Rosso Chiara , Nicolosi Aurora , Guariglia Marta , Dileo Eleonora , Armandi Angelo , Caviglia Gian Paolo , Bugianesi Elisabetta
Published: July 2023

Patients with non-alcoholic fatty liver disease (NAFLD) display impaired health-related quality of life (HRQoL) that is often linked to an unhealthy dietary pattern. The aim of this work was to investigate the impact of HRQoL and adherence to the Mediterranean diet on the risk of liver fibrosis (LF) in patients with NAFLD. LF was assessed in 244 patients through transient elastography (FibroScan®530. Echosens, Paris, France). Significant LF was defined according to liver stiffness measurements (LSM) values ≥ 7.1 kPa. The Mediterranean diet score and the Short Form-36 questionnaires were also completed. The median age was 54 (44–62) years and 57% of participants were male. A total of 42 (17.2%) participants had LSM ≥ 7.1 kPa and showed increased GGT (p = 0.001), glucose (p < 0.001), and triglycerides levels (p = 0.015) compared to those with LSM ≤7.0 kPa. Moreover, patients with significant LF had significantly lower scores related to Physical Functioning (p < 0.001) and Role Physical (p < 0.001). In the logistic regression analysis, lower role physical and lower adherence to the MedDiet (p = 0.001 and p = 0.009, respectively), after adjusting for age, diabetes, and obstructive sleep apnea, were associated with an increased risk of significant LF. Low adherence to MedDiet and low role physical may influence the risk of significant liver fibrosis in patients with NAFLD.
Exploring the Efficacy of Extracts for Cosmetic Creams: In Vivo and In Vitro Assessments
Authors: Papa Cristina Monica , Suciu Alexandru , Dopcea Ioan , Ene Nicoleta , Singh Sandeep Kumar , Vamanu Emanuel
Published: July 2023

Plants with therapeutic potential are a rich resource for the inhabitants of a country, with Romania among them, having a diverse flora not only from plants but also from fungi. New trends in biopharmaceuticals are also addressed in studies related to topical administration, representing a great advantage; research has determined biological activities in vivo and in vitro. This study aimed to present the main active compounds from extracts of Lactarius piperatus, Centaurea cyanus, and Ribes rubrum. In vitro (DPPH scavenging activity and reducing power) and in vivo activities were determined. A survey of hydrating cosmetic products and the completion of a patch test (in vivo test) under dermatological control were realized to confirm the skin compatibility of the product in a panel of human subjects after a single application. The cosmetic product did not induce allergic reactions, erythema, irritation, or itching. This study showed that the extracts incorporated in the formulation of the face cream had a nutricosmetic effect. The research demonstrated a result of increasing skin elasticity and an anti-inflammatory effect following direct application to the skin of volunteers. The product offered in vitro/in vivo protection against the action of free radicals; it was effective in reducing the side effects of exposure to the action of blue light.
Bioactive Molecules against Rheumatoid Arthritis by Suppressing Pyroptosis
Authors: Zhou Qian , Li Tian , Fang Gang , Pang Yuzhou , Wang Xueni
Published: July 2023

Rheumatoid arthritis is an inflammatory disease, and pyroptosis is a form of death associated with an inflammatory response. Pyroptosis, which occurs in synovial and osteoblastic cells, can exacerbate the development of rheumatoid arthritis. The inhibition of pyroptosis of these cells can, therefore, clearly be used as a therapeutic strategy against rheumatoid arthritis. Here, we have summarized the current status of progress in the treatment of rheumatoid arthritis by targeting cellular pyroptosis. We have identified seven compounds, including a cyclic RNA, a microRNA, a peptide, and a cytokine (protein), that may influence the progression of rheumatoid arthritis by regulating the initiation of pyroptosis. All of these compounds have been shown to have anti-rheumatoid effects in vitro and/or in vivo and have the potential to be developed as anti-rheumatoid agents. These findings may help to accelerate the development of anti-rheumatoid arthritis drugs.
Dysregulation of Amino Acid Transporters in a Rat Model of TLR7-Mediated Maternal Immune Activation
Authors: McColl Eliza R. , Henderson Jeffrey T. , Piquette-Miller Micheline
Published: July 2023

Maternal immune activation (MIA) during pregnancy is linked to neurodevelopmental disorders in humans. Similarly, the TLR7 agonist imiquimod alters neurodevelopment in rodents. While the mechanisms underlying MIA-mediated neurodevelopmental changes are unknown, they could involve dysregulation of amino acid transporters essential for neurodevelopment. Therefore, we sought to determine the nature of such transporter changes in both imiquimod-treated rats and human placentas during infection. Pregnant rats received imiquimod on gestational day (GD)14. Transporter expression was measured in placentas and fetal brains via qPCR (GD14.5) and immunoblotting (GD16). To monitor function, fetal brain amino acid levels were measured by HPLC on GD16. Gene expression in the cortex of female fetal brains was further examined by RNAseq on GD19. In human placentas, suspected active infection was associated with decreased ASCT1 and SNAT2 protein expression. Similarly, in imiquimod-treated rats, ASCT1 and SNAT2 protein was also decreased in male placentas, while EAAT2 was decreased in female placentas. CAT3 was increased in female fetal brains. Consistent with this, imiquimod altered amino acid levels in fetal brains, while RNAseq demonstrated changes in expression of several genes implicated in autism. Thus, imiquimod alters amino acid transporter levels in pregnant rats, and similar changes occur in human placentas during active infection. This suggests that changes in expression of amino acid transporters may contribute to effects mediated by MIA toward altered neurodevelopment.
Controlled Delivery of Celecoxib—β-Cyclodextrin Complexes from the Nanostructured Titanium Dioxide Layers
Authors: Jarosz Magdalena , Latosiński Jakub , Gumułka Paweł , Dąbrowska Monika , Kępczyński Mariusz , Sulka Grzegorz , Starek Małgorzata
Published: July 2023

Considering the potential of nanostructured titanium dioxide layers as drug delivery systems, it is advisable to indicate the possibility of creating a functional drug delivery system based on anodic TiO2 for celecoxib as an alternative anti-inflammatory drug and its inclusion complex with β-cyclodextrin. First, the optimal composition of celecoxib—β-cyclodextrin complexes was synthesized and determined. The effectiveness of the complexation was quantified using isothermal titration calorimetry (ITC), differential scanning calorimetry (DSC), infrared spectroscopy (FT-IR) nuclear magnetic resonance (1H NMR), and scanning electron microscopy (SEM). Then, nanostructured titanium dioxide layers (TiO2) were synthesized using the electrochemical oxidation technique. The TiO2 layers with pore diameters of 60 nm and layer thickness of 1.60 µm were used as drug delivery systems. The samples were modified with pure celecoxib and the β-cyclodextrin-celecoxib complex. The release profiles shown effective drug release from such layers during 24 h. After the initial burst release, the drug was continuously released from the pores. The presented results confirm that the use of nanostructured TiO2 as a drug delivery system can be effectively used in more complicated systems composed of β-cyclodextrin—celecoxib complexes, making such drugs available for pain treatment, e.g., for orthopedic surgeries.
Innovative Strategies for Drug Delivery to the Ocular Posterior Segment
Authors: Gabai Andrea , Zeppieri Marco , Finocchio Lucia , Salati Carlo
Published: July 2023

Innovative and new drug delivery systems (DDSs) have recently been developed to vehicle treatments and drugs to the ocular posterior segment and the retina. New formulations and technological developments, such as nanotechnology, novel matrices, and non-traditional treatment strategies, open new perspectives in this field. The aim of this mini-review is to highlight promising strategies reported in the current literature based on innovative routes to overcome the anatomical and physiological barriers of the vitreoretinal structures. The paper also describes the challenges in finding appropriate and pertinent treatments that provide safety and efficacy and the problems related to patient compliance, acceptability, effectiveness, and sustained drug delivery. The clinical application of these experimental approaches can help pave the way for standardizing the use of DDSs in developing enhanced treatment strategies and personalized therapeutic options for ocular pathologies.
A Review of Variable-Beam Divergence Angle FSO Communication Systems
Authors: Zhang Guoqiang , Wu Jiabin , Li Yatian , Wang Ximing , Yu Xichang , Gao Shijie , Ma Lie
Published: July 2023

Free-space optical (FSO) communication is widely used in satellites, ships, aircraft, and ground stations due to its advantages of high speed, large capacity, good confidentiality, and strong anti-interference ability. Variable-beam divergence angle (VBDA) technology makes FSO systems more flexible; this has the benefits of higher acquisition probability, stronger tracking ability, wider communication link range, and lower energy consumption. In other words, the study of VBDA has both theoretical significance and practical relevance. This paper conducts a comprehensive search of relevant scientific databases, journals, conference proceedings, patents, and books to identify publications related to VBDA technology. We analyze these publications, classify and organize various VBDA techniques based on their respective methods. To the best of our knowledge, this is the first review of VBDA technology. In this paper, we first explain the basic principle of changing the beam divergence angle by employing the ABCD matrix, and further furnish a detailed overview of the methods used for VBDA along with their corresponding advantages and disadvantages. In addition, we provide a comprehensive summary of the research conducted using VBDA technology across different link types. Lastly, we identify the challenges and potential future research directions for VBDA technology.
Angle-Selective Photodetection in Ge/Si Quantum Dot Photodiodes Enhanced by Microstructured Hole Arrays
Authors: Yakimov Andrew I. , Kirienko Victor V. , Bloshkin Aleksei A. , Utkin Dmitrii E. , Dvurechenskii Anatoly V.
Published: July 2023

We report on the near-infrared (NIR) photoresponse of a micropatterned Ge/Si quantum dot (QD) pin photodiode at different angles of radiation incidence. The photon-trapping hole array was etched through the n+-type top contact layer to reach the buried QDs. The normal-incidence responsivity was observed to be resonantly increased at wavelengths of 1.4, 1.7, and 1.9 μm by factors of 40, 33, and 30, respectively, compared with the reference detector without holes. As the incident angle θ increases, the resonance peaks are disappeared and at θ>40∘ a new resonance with a 25× enhancement arises at a wavelength of 1.8 μm. Simulation of the near-field intensity, Poynting vector distribution and wave polarization showed that at small θ, the strong electric field is primarily localized under the air holes (1.4 μm, TM mode) or between the holes (1.7 and 1.9 μm, TE modes) inside the region occupied by QDs, resulting in the strong NIR photocurrent. At large θ, the dominant resonance detected at 1.8 μm is the result of coupling between the TE and TM modes and formation of a mixed near-field state.
Heavy Metal Contamination Alters the Co-Decomposition of Leaves of the Invasive Tree Rhus typhina L. and the Native Tree Koelreuteria paniculata Laxm
Authors: Xu Zhelun , Zhong Shanshan , Yu Youli , Li Yue , Li Chuang , Xu Zhongyi , Liu Jun , Wang Congyan , Du Daolin
Published: July 2023

Invasive and native plants can coexist in the same habitat; however, the decomposition process may be altered by the mixing of invasive and native leaves. Heavy metal contamination may further alter the co-decomposition of both leaf types. This study evaluated the effects of two concentrations (35 mg·L−1 and 70 mg·L−1) and three types (Pb, Cu, and combined Pb + Cu) of heavy metal contamination on the co-decomposition of leaves of the invasive tree Rhus typhina L. and the native tree Koelreuteria paniculata Laxm, as well as the mixed effect intensity of the co-decomposition of the mixed leaves. A polyethylene litterbag experiment was performed over six months. The decomposition coefficient of the two trees, mixed effect intensity of the co-decomposition, soil pH and enzymatic activities, soil bacterial alpha diversity, and soil bacterial community structure were determined. A high concentration of Pb and combined Pb + Cu significantly reduced the decomposition rate of R. typhina leaves. A high concentration of Pb or Cu significantly reduced the decomposition rate of the mixed leaves. In general, R. typhina leaves decomposed faster than K. paniculata leaves did. There were synergistic effects observed for the co-decomposition of the mixed leaves treated with combined Pb + Cu, regardless of concentration, but there were antagonistic effects observed for the co-decomposition of the mixed leaves treated with either Pb or Cu, regardless of concentration. A high concentration of Pb or Cu may increase antagonistic effects regarding the co-decomposition of mixed-leaf groups. Thus, heavy metal contamination can significantly affect the intensity of the mixed effect on the co-decomposition of heterogeneous groups of leaves.
Environmental Impacts Assessment in Suspension PVC Production Process Using Computer-Aided Process Engineering
Authors: González-Delgado Ángel Darío , Ramos-Olmos Miguel , Aguilar-Vásquez Eduardo
Published: July 2023

The new demands for sustainable operation in the chemical industry due to increasing environmental regulations and agreements have generated the need to adapt existing processes to more intelligent production. The plastics sector is in a complex position due to its contribution to economic development and the climate crisis. Therefore, environmental assessment has become an important tool due to the benefits it provides by quantifying the environmental performance of processes, allowing it to balance operational and environmental needs. Polyvinyl chloride (PVC) is one of the most globally used polymers thanks to its resistance, flexibility, and cost-effectiveness. The polymer is synthetized by suspension polymerization, which is characterized by high productivity and controllability. However, it presents problems associated with intensive energy consumption and the emission of toxic substances and greenhouse gases. Therefore, an environmental assessment of the suspension PVC production process was performed using the waste reduction algorithm (WAR). The potential environmental impact (PEI) was quantified using the generation rate and the output velocity for four cases and three different fuels. It was found that the process transforms raw materials with high impacts, such as VCM, into substances with lower PEI, such as PVC. However, the process has a high generation of PEI due to the effects of energy consumption (−2860, −2410, 3020, and 3410 for cases 1–4, respectively). The evaluation of the toxicological impacts shows that the ATP category is the only one that presents a positive generation value (75 PEI/day); the product contributes to the formation and emission of impacts. The atmospheric categories showed that the energy consumption of the process is the most critical aspect with a contribution of 91% of the total impacts emitted. The AP and GWP categories presented the highest values. It was determined that the most suitable fuel is natural gas; it has lower impacts than liquid and solid fuels (coal). Additionally, it can be concluded that the PVC production process by suspension is environmentally acceptable compared to the polyethylene or polypropylene processes, with output impacts 228 and 2561 times lower, respectively.
A Comprehensive Review of Polysaccharide-Based Hydrogels as Promising Biomaterials
Authors: Berradi Achraf , Aziz Faissal , Achaby Mounir El , Ouazzani Naaila , Mandi Laila
Published: July 2023

Polysaccharides have emerged as a promising material for hydrogel preparation due to their biocompatibility, biodegradability, and low cost. This review focuses on polysaccharide-based hydrogels’ synthesis, characterization, and applications. The various synthetic methods used to prepare polysaccharide-based hydrogels are discussed. The characterization techniques are also highlighted to evaluate the physical and chemical properties of polysaccharide-based hydrogels. Finally, the applications of SAPs in various fields are discussed, along with their potential benefits and limitations. Due to environmental concerns, this review shows a growing interest in developing bio-sourced hydrogels made from natural materials such as polysaccharides. SAPs have many beneficial properties, including good mechanical and morphological properties, thermal stability, biocompatibility, biodegradability, non-toxicity, abundance, economic viability, and good swelling ability. However, some challenges remain to be overcome, such as limiting the formulation complexity of some SAPs and establishing a general protocol for calculating their water absorption and retention capacity. Furthermore, the development of SAPs requires a multidisciplinary approach and research should focus on improving their synthesis, modification, and characterization as well as exploring their potential applications. Biocompatibility, biodegradation, and the regulatory approval pathway of SAPs should be carefully evaluated to ensure their safety and efficacy.
Extraction, Isolation, Screening, and Preliminary Characterization of Polysaccharides with Anti–Oxidant Activities from Oudemansiella raphanipies
Authors: Qiu Junqiang , Shi Wang , Miao Jingnan , Hu Hui , Gao Yanan
Published: July 2023

Response surface methodology (RSM) was used to find the optimal extraction process of Oudemansiella raphanipies polysaccharides (ORPs). The results showed that the optimal extraction parameters were an alkali concentration of 0.02 mol/L, a ratio of material to liquid of 1:112.7 g/mL, an extraction temperature of 66.0 °C, and an extraction time of 4.0 h. Under the optimal conditions, the yield of ORPs was raised to 16.2 ± 0.1%. The antioxidant activities of ORPs–I~V were determined and compared, and ORPs–V was further purified by chromatography, with an average molecular weight (Mw) of 18.86 kDa. The structure of ORPs–V was determined by Fourier transform–infrared spectroscopy (FT–IR), monosaccharide analysis, and nuclear magnetic resonance (NMR) spectroscopy. The ORPs–V comprised fucose, rhamnose, arabinose, glucose, galactose, mannose, xylose, fructose, galacturonic acid, and glucuronic acid at a ratio of 1.73:1.20:1.13:2.87:8.71:2.89:1.42:0.81. Compared to other ORPs, ORPs–V showed the strongest antioxidant activities (ABTS radical cation, hydroxyl radical and DPPH scavenging activities, and reducing power), and were able to significantly increase the activities of superoxide dismutase, catalase, lactate dehydrogenase, and glutathione peroxidase. However, they reduced the malondialdehyde content in mice fed a high-fat diet. These results indicate that ORPs–V may be good anti–oxidant agents to be applied in functional foods.