bluuebunny/crossref_metadata_2025 huggingface dataset:
Global Absence and Targeting of Protective Immune States in Severe COVID-19.
Authors: Krummel Matthew , Combes Alexis , Courau Tristan , Kuhn Nicholas , Hu kenneth , Ray Arja , Chen William , Cleary Simon , Chew Nayvin , Kushnoor Divyashree , Reeder Gabriella , Shen Alan , Tsui Jessica , Hiam Kamir , Sandoval Priscila Munoz , Zhu Wandi , Lee David , Sun Yang , You Ran , Magnen Melia , Rodriguez Lauren , Leligdowicz Aleksandra , Zamecnik Colin , Loudermilk Rita , Wilson Michael , Ye Chun , Fragiadakis Gabriela , Looney Mark , Chan Vincent , Ward Alyssa , Carrillo Sidney , Matthay Michael , Erle David , Woodruff Prescott , Langelier Charles , Kangelaris Kristen , Hendrickson Carolyn , Calfee Carolyn , Rao Arjun
Published: October 2020

While SARS-CoV-2 infection has pleiotropic and systemic effects in some patients, many
others experience milder symptoms. We sought a holistic understanding of the
severe/mild distinction in COVID-19 pathology, and its origins. We performed a wholeblood
preserving single-cell analysis protocol to integrate contributions from all major cell
types including neutrophils, monocytes, platelets, lymphocytes and the contents of
serum. Patients with mild COVID-19 disease display a coordinated pattern of interferonstimulated
gene (ISG) expression across every cell population and these cells are
systemically absent in patients with severe disease. Severe COVID-19 patients also
paradoxically produce very high anti-SARS-CoV-2 antibody titers and have lower viral load
as compared to mild disease. Examination of the serum from severe patients
demonstrates that they uniquely produce antibodies with multiple patterns of specificity
against interferon-stimulated cells and that those antibodies functionally block the
production of the mild disease-associated ISG-expressing cells. Overzealous and autodirected
antibody responses pit the immune system against itself in many COVID-19
patients and this defines targets for immunotherapies to allow immune systems to
provide viral defense.
Early Postoperative Clinical Outcomes of Robotic Arm-Assisted Vs. Image-Based Navigated Total Hip Arthroplasty
Authors: Shibanuma Nao , Ishida Kazunari , Matsumoto Tomoyuki , Takayama Koji , Sanada Yutaro , Kurosaka Masahiro , Kuroda Ryosuke , Hayashi Shinya
Published: October 2020

Background The purpose of this study was to compare the clinical outcomes of total hip arthroplasty (THA) using computer navigation systems (nTHA) and those of robotic arm-assisted THA (rTHA).Methods Thirty prospective subjects who underwent rTHA were clinically compared with 30 subjects who underwent nTHA. Clinical data (the surgical time, intraoperative blood loss, length of hospital stay, pain severity, number of days to independent walking, and Harris Hip Score (HHS) at discharge) and radiographic parameters (the inclination and anteversion angles) were statistically compared between the two groups. Results The surgical time, number of days to independent walking, and postoperative pain were significantly reduced in the rTHA group than in the nTHA group. The rTHA group showed a significantly higher postoperative HHS than did the nTHA group. No statistically significant difference was observed in radiographic parameters between the groups.Conclusion The surgical time, postoperative pain, and number of days to independent walking were significantly shorter, and the HHS at discharge was significantly higher in the rTHA group than in the nTHA group. Thus, as compared to nTHA, rTHA improved early clinical outcomes.
Construction of circRNA-based ceRNA Network to Reveal the Role of circRNAs in the Progression and Prognosis of Hepatocellular Carcinoma
Authors: Deng Rong , Cui XiaoHan , Dong Yuxiang , Tang Yanqiu , Tao Xuewen , Wang Shuyu , Wang Jin-cheng , Chen Lin
Published: October 2020

Background: Circular RNAs (circRNAs) are now under hot discussion as novel promising bio-markers for patients with hepatocellular carcinoma. The purpose of our study is to identify several competing endogenous RNAs (ceRNAs) networks related to the prognosis and progression of hepatocellular carcinoma, and to further investigate the mechanism of their influence on tumor progression.Methods: First, we obtained gene expression data related to liver cancer from the TCGA database (http://www.portal.gdc.cancer.gov/), including miRNA-seq, RNA-seq and clinical information. A co-expression network was constructed through the WGCNA software package in R software, with the purpose of identifying important microRNAs (miRNAs) and messenger RNAs (mRNAs) related to liver cancer. The DEmRNAs in the key module were analyzed with DAVID (https://david.ncifcrf.gov/summary.jsp) to perform functional enrichment analysis including Kyoto Encyclopedia of Genes and Genomes (KEGG) and gene ontology (GO). The data of miRNA expression and clinical information downloaded from TCGA was utilized for survival analysis to detach the prognostic value of the DEmiRNAs of the key module. Results：201 DEmiRNAs and 3783 DEmRNAs were finally identified through differential expression analysis. The co-expression networks of DEmiRNA and DEmRNA were constructed by using WGCNA. Further analysis confirmed 4 miRNAs in the most significant module (blue module) were associated with the OS of patients with liver cancer, including hsa-miR-92b-3p, hsa-miR-122-3p, hsa-miR-139-5p and hsa-miR-7850-5p. DAVID was used for functional enrichment analysis of 286 co-expressed mRNAs. The Gene Ontology (GO) analysis results showed that the top enriched GO terms were oxidation-reduction process, extracellular exosome and iron ion binding. In Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, the top 3 enriched terms included metabolic pathways, fatty acid degradation and valine, leucine and isoleucine degradation. In addition, we corssed the miRNA-mRNA interactions prediction results with the differentially expressed and prognostic mRNAs, and found that hsa-miR-92b-3p can be related to cytoplasmic polyadenylation element binding protein 3 (CPEB3) and Acyl-CoA Dehydrogenase Long Chain (ACADL). By overlapping the data of predicted circRNAs by circBank and differentially expressed circRNAs of GSE94508, we screened has_circ_0077210 as the upstream regulatory molecule of hsa-miR-92b-3p. Hsa_circ_0077210/hsa-miR-92b-3p/CPEB3&ACADL were validated in hepatic cell carcinoma (HCC) tissues and human protein atlas (HPA) database.Conclusion: Our research provides a mechanistic elucidation of the unknown ceRNA regulatory network in HCC. Hsa_circ_0077210 might serve as an important biomarker to promote the occurrence and development of HCC.
Label-Free Proteomic Analysis Uncovers SMC1A Expression is Down-regulated in AUB-E Patients
Authors: Jia Yingxian , Luo Jie , Lan Yibing , Li Chunming , Ma Linjuan , Zhu Xiaoming , Ruan Fei , Zhou Jianhong
Published: October 2020

Background: While heavy menstrual bleeding (HMB) is a prevalent symptom among women with abnormal uterine bleeding caused by the primary endometrial disorder (AUB-E) seeking gynecologic care, the primary endometrial disorder remains poorly understood. Methods: 5 human endometrial samples from women with AUB-E to healthy women and the age-matched healthy women were selected. Proteins from the samples were analyzed by a linear ion trap (LTQ)-Orbitrap Elite mass spectrometer based label-free proteomic approach. Results: A total of 2138 protein groups were quantified under highly stringent criteria with a false discovery rate of < 1% for protein groups, and 317 proteins were significantly changed between the two groups. Combined the results from enriched analysis and protein−protein interaction network analysis showed that the down-regulation of structural maintenance of chromosomes protein 1 A (SMC1A) in AUB-E patients. validated by western blot and immunohistochemistry.Conclusion: The results indicated novel evidence that SMC1A change of the endometrium in women with AUB-E may be associated with the key biological mechanisms (such as cell proliferation) underlying human endometrial remodeling.
New archaeological data on the upper Paleolithic site of cueva de Malalmuerzo (Moclín, Granada, Spain)
Authors: Cabello Lidia , Cantalejo Pedro , Espejo Mª de Mar , Buendía Antonio F. , Fernández José M. , González Ríos Manuel , González Olga , Durán Juan José , Robledo Pedro , Avezuela Bárbara , Jordá Pardo Jesús F. , Uzquiano Paloma , Riquelme José A. , Ruiz-Zapata Blanca , Gil-García María J. , Ramos Muñoz José , Weniger Gerd-Christian , Palomo Alfonso , Smith Víctor Manuel , Becerra Serafín , Salvador Fernández Diego , Domínguez-Bella Salvador , Tafelmaier Yvonne , Vijande-Vila Eduardo
Published: October 2020

The Malalmuerzo cave (Moclín, Granada, Spain) has been known since the 1980s for its archaeological remains and rock art, dated to the Neolithic and the Solutrean periods respectively. However, following thirty years of neglect, our team carried out a brief archaeological intervention after looters destroyed parts of the sediment fill of the cave. The refreshing of disturbed surfaces and the examination of a small undisturbed profile produced many archaeological remains attributed to several Magdalenian levels. The levels partially covered the depiction of a red horse, which probably dates to the Solutrean period.
A Randomized Study on the Bioequivalence of Desloratadine in Healthy Chinese Subjects and the Association of Different Metabolic Phenotypes With UGT2B10 and CYP2C8 Genotypes
Authors: Niu Suping , Li Yan , Dong Wenliang , Xia Lin , Shen Tiantian , Wang Jiaxue , Wang Qian , Zhang Tan , Zhang Minjie , Liu Gang , Guo Danjie , Fang Yi
Published: October 2020

Background:

Desloratadine is a drug with a phenotypic polymorphism in metabolism and has been
approved for use in many countries to treat allergic diseases. CYP2C8 and UGT2B10 are metabolic enzymes,
which may be involved in the metabolism of desloratadine.

Objective:

This study aimed to demonstrate bioequivalence between the test product (desloratadine tablet) and
the reference product AERIUS (5mg), both orally administered. And the role of UGT2B10 and CYP2C8 genotypes
in healthy Chinese subjects with different Desloratadine metabolic phenotypes was examined.

Methods:

It was a randomized, open-label, and four-sequence, single-dose crossover study conducted on 56
healthy Chinese subjects. The pharmacokinetics (PK) and safety of the test and reference Desloratadine products
were compared. UGT2B10 and CYP2C8 genotypes were determined by the TaqMan assay using genomic
DNA. Multiple linear regression was applied to analyze the correlation between genotypes and the metabolic ratio.

Results:

The mean serum concentration-time curves of desloratadine and 3-OH-desloratadine were similar between
the test product and the reference product. For the PK similarity comparison, the 90% CIs for the geometric
mean ratios of Cmax, AUC0-t, and AUC0-∞ of desloratadine and 3-OH-desloratadine of test and reference product
were completely within 80-125%. None of all 56 subjects had serious adverse events. Only 2 subjects were
poor-metabolizers in 56 healthy subjects. There was no significant correlation between investigated genotypes
of CYP2C8 and UGT2B10 and the metabolic ratio.

Conclusion:

The test desloratadine tablet was bioequivalent to the reference product. No direct relationship between
CYP2C8 and UGT2B10 genotypes and desloratadine metabolic ratio was identified.
Progress in Detection of Insomnia Sleep Disorder: A Comprehensive Review
Authors: Bin Heyat Md Belal , Akhtar Faijan , Ansari M.A. , Khan Asif , Alkahtani Fahed , Khan Haroon , Lai Dakun
Published: October 2020

Lack of adequate sleep is a major source of many harmful diseases related to heart, brain, psychological changes, high blood pressure, diabetes, weight gain, etc. 40 to 50% of the world’s population is suffering from poor or inadequate sleep. Insomnia is a sleep disorder in which an individual complaint of difficulties in starting/continuing sleep at least four weeks regularly. It is estimated that 70% of heart diseases are generated during insomnia sleep disorder. The main objective of this study is to determine all work conducted on insomnia detection and to make a database. We used two procedures including network visualization techniques on two databases including PubMed and Web of Science to complete this study. We found 169 and 36 previous publications of insomnia detection in the PubMed and the Web of Science databases, respectively. We analyzed 10 datasets, 2 databases, 21 genes, and 23 publications with 30105 subjects of insomnia detection. This work has revealed the future way and gap so far directed on insomnia detection and has also tried to provide objectives for the future work to be proficient in a scientific and significant manner.
The Development of the Vital Signs Tele-monitoring System for the Elderly by Using ‘UML’ Language and the Interoperability Standard ‘Continua’
Authors: Mansouri Sofiene
Published: October 2020

Aims:

We aim to develope a system allowing the telemonitoring of the elderly health status. Medical telemonitoring can make life easy and safe for elderly. The goal of this project is the development of a medical telemonitoring application.

Background:

Medical telemonitoring can make life easy and safe for elderly.

Objective:

The goal of this project is the development of a medical telemonitoring application.

Methods:

In this paper we exposed the different steps of the developing of a medical telemonitoring system designed for the elderly. We studied the medical needs and the system specifications. We used the UML language. Then we detailed the designed system with a total respect to the standard for the interoperability of connected medical equipment, Continua. We presented printed screens of the realized interfaces.

Results:

We realized an application based on web development, more specifically development of a management application for medical telemonitoring.

Conclusion:

In terms of perspectives, we aim to integrate security protocols in the developed system, integrate the data sent from the sensors into an E, H & R (HER) and send the patient file to a H, I & S (HIS).
Positional control of a parallel kinematics mechatronic manipulator linear drive
Authors: Slobodzyan N. S.
Published: October 2020

The research is part of the current work on the design and research of precision actuators with parallel kinematics, designed to guide and orient of various objects. To protect the sensitive load and the supporting platform from undesirable disturbances above the permissible ones, as well as to limit the time of transient processes and the consumed power, a method for planning the trajectory of the linear actuator stem when operating in positional mode is proposed. The article describes an algorithm for calculating the parameters of the trajectory of an object under specified restrictions on speed, acceleration and acceleration derivative, and also proposes an algorithm for implementing control along a planned trajectory for a modern microprocessor system, which implements the dependence of speed on movement. The advantage of the proposed control method is the elimination of the cumulative effect of the static displacement error while observing dynamic constraints, as well as the possibility of using algorithms in both closed-loop and open-loop drives based on various types of electric motors. The article presents the results of computer simulation of an open-loop drive operating according to the proposed algorithm, the advantages and disadvantages of this approach are noted.
Con-vergence
Authors: Laddusaw Sierra , Brett Jeremy
Published: October 2020

Popular culture conventions (cons) can be powerful opportunities for library outreach, but they are underutilized or ignored as possibilities for many libraries. This article summarizes the results of a survey of libraries concerning their own con attendance/non-attendance as well as perceived benefits and actual barriers to attending. We also discuss our own experiences attending cons, including lessons learned and benefits gained by our own institution.
Campus Engagement: Faculty Recognition and the Library's Role
Authors: Kelly Safin  , Renee Kiner
Published: October 2020

As faculty librarians on a regional campus of a research university, attending meetings is one way we stay connected to our faculty colleagues. On several occasions at these events, faculty commented about a need for their work outside the classroom to be recognized in a more public forum. As we are always looking for ways to serve and engage with our campus, we considered if the library could somehow meet this need. Providing a showcase for faculty accomplishments could potentially help faculty connect with each other, show students examples of research and scholarship by their instructors, and give us another opportunity to talk with faculty about how we can support them and their students. From there, a Faculty Recognition Event hosted by our library took shape. Early in this process, we reached out to Academic Affairs, as this office is among the most engaged with the teaching and scholarship of faculty. Through this partnership, we built a framework for organizing the event: types of work to feature, ways to get the information, when and where the event should take place, and more. Although the process was not always smooth, the first event met our expectations of highlighting faculty scholarship, service, presentations, and grants or other awards. Hosting a casual lunchtime event featuring this work presented outreach opportunities we may not have otherwise had. The lessons learned from the first attempt informed the approach we took to plan a second, more well-attended event.
New Beginnings:
Authors: Thacker Mara , Roberts Matthew , Christensen Sarah
Published: October 2020

It is Tuesday, April 2 2019. On this day, like many days, the three of us sat down to answer and craft emails. But on this day, we wrote to each other, responding to a simple question that we began to ponder: “What if we created a peer review journal of academic librarian engagement?”.
A Recursive Model of the Spread of COVID-19: Modelling Study
Authors: Ilyin Sergey O
Published: October 2020

Background

The major medical and social challenge of the 21st century is COVID-19, caused by the novel coronavirus SARS-CoV-2. Critical issues include the rate at which the coronavirus spreads and the effect of quarantine measures and population vaccination on this rate. Knowledge of the laws of the spread of COVID-19 will enable assessment of the effectiveness and reasonableness of the quarantine measures used, as well as determination of the necessary level of vaccination needed to overcome this crisis.

Objective

This study aims to establish the laws of the spread of COVID-19 and to use them to develop a mathematical model to predict changes in the number of active cases over time, possible human losses, and the rate of recovery of patients, to make informed decisions about the number of necessary beds in hospitals, the introduction and type of quarantine measures, and the required threshold of vaccination of the population.

Methods

This study analyzed the onset of COVID-19 spread in countries such as China, Italy, Spain, the United States, the United Kingdom, Japan, France, and Germany based on publicly available statistical data. The change in the number of COVID-19 cases, deaths, and recovered persons over time was examined, considering the possible introduction of quarantine measures and isolation of infected people in these countries. Based on the data, the virus transmissibility and the average duration of the disease at different stages were evaluated, and a model based on the principle of recursion was developed. Its key features are the separation of active (nonisolated) infected persons into a distinct category and the prediction of their number based on the average duration of the disease in the inactive phase and the concentration of these persons in the population in the preceding days.

Results

Specific values for SARS-CoV-2 transmissibility and COVID-19 duration were estimated for different countries. In China, the viral transmissibility was 3.12 before quarantine measures were implemented and 0.36 after these measures were lifted. For the other countries, the viral transmissibility was 2.28-2.76 initially, and it then decreased to 0.87-1.29 as a result of quarantine measures. Therefore, it can be expected that the spread of SARS-CoV-2 will be suppressed if 56%-64% of the total population becomes vaccinated or survives COVID-19.

Conclusions

The quarantine measures adopted in most countries are too weak compared to those previously used in China. Therefore, it is not expected that the spread of COVID-19 will stop and the disease will cease to exist naturally or owing to quarantine measures. Active vaccination of the population is needed to prevent the spread of COVID-19. Furthermore, the required specific percentage of vaccinated individuals depends on the magnitude of viral transmissibility, which can be evaluated using the proposed model and statistical data for the country of interest.
Reducing Alert Fatigue by Sharing Low-Level Alerts With Patients and Enhancing Collaborative Decision Making Using Blockchain Technology: Scoping Review and Proposed Framework (MedAlert)
Authors: Wan Paul Kengfai , Satybaldy Abylay , Huang Lizhen , Holtskog Halvor , Nowostawski Mariusz
Published: October 2020

Background

Clinical decision support (CDS) is a tool that helps clinicians in decision making by generating clinical alerts to supplement their previous knowledge and experience. However, CDS generates a high volume of irrelevant alerts, resulting in alert fatigue among clinicians. Alert fatigue is the mental state of alerts consuming too much time and mental energy, which often results in relevant alerts being overridden unjustifiably, along with clinically irrelevant ones. Consequently, clinicians become less responsive to important alerts, which opens the door to medication errors.

Objective

This study aims to explore how a blockchain-based solution can reduce alert fatigue through collaborative alert sharing in the health sector, thus improving overall health care quality for both patients and clinicians.

Methods

We have designed a 4-step approach to answer this research question. First, we identified five potential challenges based on the published literature through a scoping review. Second, a framework is designed to reduce alert fatigue by addressing the identified challenges with different digital components. Third, an evaluation is made by comparing MedAlert with other proposed solutions. Finally, the limitations and future work are also discussed.

Results

Of the 341 academic papers collected, 8 were selected and analyzed. MedAlert securely distributes low-level (nonlife-threatening) clinical alerts to patients, enabling a collaborative clinical decision. Among the solutions in our framework, Hyperledger (private permissioned blockchain) and BankID (federated digital identity management) have been selected to overcome challenges such as data integrity, user identity, and privacy issues.

Conclusions

MedAlert can reduce alert fatigue by attracting the attention of patients and clinicians, instead of solely reducing the total number of alerts. MedAlert offers other advantages, such as ensuring a higher degree of patient privacy and faster transaction times compared with other frameworks. This framework may not be suitable for elderly patients who are not technology savvy or in-patients. Future work in validating this framework based on real health care scenarios is needed to provide the performance evaluations of MedAlert and thus gain support for the better development of this idea.
Digital Interventions for Depression and Anxiety in Older Adults: Protocol for a Systematic Review
Authors: Riadi Indira , Kervin Lucy , Teo Kelly , Churchill Ryan , Cosco Theodore D
Published: October 2020

Background

There is a high prevalence of older adults experiencing depression and anxiety. In response to heightened demands for mental health interventions that are accessible and affordable, there has been a recent rise in the number of digital mental health interventions (DMHIs) that have been developed and incorporated into mental health treatments. Digital interventions are promising in their ability to provide researchers, medical practitioners, and patients with personalized tools for assessing behavior, consultation, treatment, and care that can be used remotely. Reviews and meta-analyses have shown the benefits of DMHIs for the treatment and prevention of depression, anxiety, and other mental illnesses, but there is still a lack of studies that focus on the benefits and use of DMHIs in the older population.

Objective

The aim of this systematic review is to investigate the current evidence for the effect of technology-delivered interventions, such as smartphone/tablet applications, remote monitoring and tracking devices, and wearable technology, for the treatment and prevention of depression and anxiety in adults older than 50 years.

Methods

The academic databases SCOPUS, PsycINFO, AgeLine (EBSCO), and Medline (PubMed) will be searched from January 1, 2010, to the date of search commencement to provide a review of existing randomized controlled trial studies. The search will include 3 key concepts: “older adults,” “digital intervention,” and “depression/anxiety.” A set of inclusion criteria will be followed during screening by two reviewers. Data will be extracted to address aims and objectives of the review. The risk of bias for each study will be determined using appropriate tools. If possible, a random-effects meta-analysis will be performed, and the heterogeneity of effect sizes will be calculated.

Results

Preliminary searches were conducted in September 2020. The review is anticipated to be completed by April 2021.

Conclusions

The data accumulated in this systematic review will demonstrate the potential benefits of technology-delivered interventions for the treatment of depression and anxiety disorders in older adults. This review will also identify any gaps in current studies of aging and mental health interventions, thereby navigating a way to move forward and paving the path to more accessible and user-friendly digital health interventions for the diverse population of older adults.

Trial Registration

PROSPERO International Prospective Register of Systematic Reviews CRD42020192532; https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42020192532

International Registered Report Identifier (IRRID)

PRR1-10.2196/22738
Anxiety and Suicidal Thoughts During the COVID-19 Pandemic: Cross-Country Comparative Study Among Indonesian, Taiwanese, and Thai University Students
Authors: Pramukti Iqbal , Strong Carol , Sitthimongkol Yajai , Setiawan Agus , Pandin Moses Glorino Rumambo , Yen Cheng-Fang , Lin Chung-Ying , Griffiths Mark D , Ko Nai-Ying
Published: October 2020

Background

The COVID-19 pandemic has negatively affected the mental health of university students.

Objective

This study examined the psychological responses toward COVID-19 among university students from 3 countries—Indonesia, Taiwan, and Thailand.

Methods

We used a web-based, cross-sectional survey to recruit 1985 university students from 5 public universities (2 in Indonesia, 1 in Thailand, and 1 in Taiwan) via popular social media platforms such as Facebook, LINE, WhatsApp, and broadcast. All students (n=938 in Indonesia, n=734 in Thailand, and n=313 in Taiwan) answered questions concerning their anxiety, suicidal thoughts (or sadness), confidence in pandemic control, risk perception of susceptibility to infection, perceived support, resources for fighting infection, and sources of information in the context of the COVID-19 pandemic.

Results

Among the 3 student groups, Thai students had the highest levels of anxiety but the lowest levels of confidence in pandemic control and available resources for fighting COVID-19. Factors associated with higher anxiety differed across countries. Less perceived satisfactory support was associated with more suicidal thoughts among Indonesian students. On the other hand, Taiwanese students were more negatively affected by information gathered from the internet and from medical staff than were Indonesian or Thai students.

Conclusions

Our findings suggest that health care providers in Thailand may need to pay special attention to Thai university students given that high levels of anxiety were observed in this study population. In addition, health care providers should establish a good support system for university students, as the results of this study indicate a negative association between support and suicidal thoughts.
Route and Bus Stop Plan of Agglomeration Transportation on Educational Facility in Yogyakarta Urban Agglomeration Area
Authors: Khaerunnisa Syifa Hapsari
Published: October 2020

Urban Public Transportation has important existence to make good urban transportation. To realize it, the objective of this research is to improve Trans Jogja service as Yogyakarta Urban Agglomeration Transportation that appropriate for student needs. The plan that will be formulated in this research is focused on route and bus stop distribution in educational facility that covering high schools and universities located in Yogyakarta Agglomeration Area. Route plan formulation is done with manual assignment method through total road network trip assignment based on origin destination matrix of school trip. Then, to formulate bus stop plan is done with spatial analytical method that covering bus stop accessibility to schools and universities through 2 scenarios, the first scenario is about 200-meters radius of accessibility and second scenario is 500-meters radius of accessibility. The result is there will be 31 new routes of Yogyakarta Urban Agglomeration Transportation that will reach the whole sub-district in Yogyakarta Agglomeration Area include Godean and Ngemplak Sub-District that previously are not served by Trans Jogja. That new routes are consist of 3 outer city routes (OCR), 23 inner city routes (ICR) and 5 connecting routes that connecting sub-urban and urban area. Then, the bus stop is planned along new route plan and focused on residential land use in sub-urban area, high schools, and universities. On the first scenario with radius of 200-meter, there is 99 units of additional bus stop plan, while on the second scenario with radius of 500 meters is 66 units. Thus, second scenario is assumed better than the first scenario because of more schools and universities are served by Trans Jogja.
Intravenous Albumin for Mitigating Hypotension and Augmenting Ultrafiltration during Kidney Replacement Therapy
Authors: Hryciw Nicole , Joannidis Michael , Hiremath Swapnil , Callum Jeannie , Clark Edward G.
Published: October 2020

Among its many functions, owing to its oversized effect on colloid oncotic pressure, intravascular albumin helps preserve the effective circulatory volume. Hypoalbuminemia is common in hospitalized patients and is found especially frequently in patients who require KRT either for AKI or as maintenance hemodialysis. In such patients, hypoalbuminemia is strongly associated with morbidity, intradialytic hypotension, and mortality. Intravenous albumin may be administered in an effort to prevent or treat hypotension or to augment fluid removal, but this practice is controversial. Theoretically, intravenous albumin administration might prevent or treat hypotension by promoting plasma refilling in response to ultrafiltration. However, clinical trials have demonstrated that albumin administration is not nearly as effective a volume expander as might be assumed according to its oncotic properties. Although intravenous albumin is generally considered to be safe, it is also very expensive. In addition, there are potential risks to using it to prevent or treat intradialytic hypotension. Some recent studies have suggested that hyperoncotic albumin solutions may precipitate or worsen AKI in patients with sepsis or shock; however, the overall evidence supporting this effect is weak. In this review, we explore the theoretical benefits and risks of using intravenous albumin to mitigate intradialytic hypotension and/or enhance ultrafiltration and summarize the current evidence relating to this practice. This includes studies relevant to its use in patients on maintenance hemodialysis and critically ill patients with AKI who require KRT in the intensive care unit. Despite evidence of its frequent use and high costs, at present, there are minimal data that support the routine use of intravenous albumin during KRT. As such, adequately powered trials to evaluate the efficacy of intravenous albumin in this setting are clearly needed.
Economic burden of readmission due to postoperative cerebrospinal fluid leak in Chinese patients
Authors: Wu Shuqing , Cui Xin , Zhang Shaoyu , Tian Wenqi , Liu Jiazhen , Wu Yiqing , Wu Man , Han Yi
Published: October 2020

Aim:
This real-world data study investigated the economic burden and associated factors of readmissions for cerebrospinal fluid leakage (CSFL) post-cranial, transsphenoidal, or spinal index surgeries.
Methods:
Costs of CSFL readmissions and index hospitalizations during 2014–2018 were collected. Readmission cost was measured as absolute cost and as percentage of index hospitalization cost. Factors associated with readmission cost were explored using generalized linear models.
Results:
Readmission cost averaged US$2407–6106, 35–94% of index hospitalization cost. Pharmacy costs were the leading contributor. Generalized linear models showed transsphenoidal index surgery and surgical treatment for CSFL were associated with higher readmission costs.
Conclusion:
CSFL readmissions are a significant economic burden in China. Factors associated with higher readmission cost should be monitored.
Obtención y análisis de expresiones de cinética química
Authors: Cuevas-García Rogelio
Published: October 2020

En este artículo se presenta la importancia de los análisis de la cinética química. También se abordan los temas necesarios para obtener parámetros cinéticos confiables que proporcionen información del modelo cinético de reacciones catalíticas. Se describe como se realizan los ajustes de los coeficientes cinéticos y se presentan los algoritmos de mínimos cuadrados más comunes para realizar el ajuste. También se presentan los criterios estadísticos para decidir si el ajuste es adecuado. Finalmente se describen diferentes casos de como la literatura cientifica presenta los datos de actividad catalítica
‘ARS MAIOR’, DONATO: CRITÉRIOS DE ANÁLISE LINGUÍSTICA
Authors: Fortes Fábio da Silva , De Moura Marcela Zambolim
Published: October 2020

Este artigo pretende analisar o tratamento gramatical dado às partes da oração (partes orationis), na Ars maior de Donato (séc. IV d.C.). É nossa meta avaliar quais critérios são considerados na definição, especificação e ilustração das classes de palavras nessa obra. Defendemos que Donato utiliza não somente o critério “semântico”, como também se vale dos critérios “morfológico” – para distinguir e caracterizar os accidentia –, “sintático” – para indicar o estatuto funcional das classes em relação aos accidentia e às outras classes –, e “fonológico” – para descrever os exemplos e seus padrões de pronúncia.
O conto policial de Jorge Luis Borges: cânone e marginalidade
Authors: Ângelo Andréa Lúcia Padrão
Published: October 2020

A obra de Jorge Luis Borges teve influência de­cisiva na definição do perfil do século XX, espe­cialmente nas questões referentes ao mundo das letras. Escritor consagrado, demonstra inegável preferência pela literatura marginal, pelo texto fora das tradições canônicas. O presente trabalho enfoca dois contos de Borges em um gênero ainda considerado “menor”, o policial. Mostra, também, como essas narrativas aparecem vinculadas a pre­ocupações que ultrapassam o gênero, abrangendo elementos comuns ao universo borgiano: filosó­ficos, teológicos, místicos, míticos, metafísicos e históricos.
A poesia e a prosa do mundo
Authors: Pedrosa Célia
Published: October 2020

Releitura da tensão entre poesia e prosa na fundação e no percurso da literatura moderna, de modo a contextualizar e avaliar a produção poética brasileira contemporânea, nela abordando a ênfase no prosaico e no narrativo associados à composição serial, enquanto forma de encenação da experiência individual e coletiva e do papel nesta exercido pela prática literária.
Ficções do excesso e do sacrifício: Roberto Bolaño, Marcelo Mirisola e William Burroughs
Authors: Dias Ângela Maria
Published: October 2020

Este artigo pretende considerar a relação funda­mental entre melancolia e trauma na dinâmica artística e literária de hoje e sublinhar o papel do sacrifício, como um ritual inscrito no processo de criação, desde a Modernidade. Estas molduras contemporâneas da invenção estética são engen­dradas, respectivamente pela alegoria e pela pers­pectiva da abjeção, aqui abordadas como modos correlatos de produção ficcional. O ensaio adota a visão de Bataille sobre o sacrifício para discutir os romances de três significativos autores: o chileno Roberto Bolaño, o brasileiro Marcelo Mirisola e o americano William Burroughs.
Acaso e método na pesquisa das poéticas da palavra cantada: um registro de caso
Authors: Oliveira Leonardo Davino de
Published: October 2020

O artigo relata e discute um procedimento metodológico particular, utilizado pelo autor. No entanto, pela carência de meios de abordagens da questão das poéticas da palavra cantada, em particular a canção popular mediatizada, pode ser aproveitado por outros pesquisadores. O objetivo é mostrar como a coleta de dados ao acaso, pelo rádio, pode contribuir para a restituição da relação entre poesia e canção, por meio da integração de elementos como a presença do corpo na pesquisa e a relação amorosa do pesquisador com o objeto, articuladas à utilização de uma base teórica já testada e reconhecida.
A obra literária na era da explosão de signos: uma proposta semiótica de análise do romance
Authors: Santana Sergio Ricardo Lima de
Published: October 2020

Este artigo propõe uma abordagem metodológica do romance sob o ponto de vista da semiótica de Charles Sanders Peirce, utilizando como parâmetros as categorias universais da primeiridade, secundidade e terceiridade para análise do texto literário. É realizada uma breve análise do romance O talentoso Ripley, de Patricia Highsmith, com o intuito de demonstrar a aplicabilidade e pertinência da metodologia proposta. Pôde-se concluir que, diante da complexidade contemporânea no que se refere à multiplicação de signos, a abordagem pode trazer vantagens, ao tornar necessária a análise dos aspectos do romance, sem desprezar a participação da própria subjetividade do analista.
Mediações contemporâneas: tradução cultural e literatura comparada
Authors: Almeida Sandra Regina Goulart
Published: October 2020

O trabalho aborda o conceito de tradução cultural na contemporaneidade e, em especial, as propostas da teórica Gayatri Chakravorty Spivak, refletindo principalmente sobre a relação entre tradução e subalternidade, solidariedade e literatura comparada.
O espectro de Kafka na narrativa “Pena de morte”, de Maurice Blanchot
Authors: Pimentel Davi Andrade
Published: October 2020

Este trabalho analisa a presença de traços kafkianos na formação subjetiva de escrita do autor francês Maurice Blanchot, no que se refere à elaboração de uma de suas narrativas, Pena de morte. Nessa narrativa, o modo cáustico e problemático do movimento textual do narrador é muito semelhante ao movimento kafkiano que se manifesta no Diário Íntimo e nos romances do escritor tcheco, dando-nos material necessário para investigarmos a influência de Franz Kafka no escrito de Maurice Blanchot em análise.
Política linguística para as línguas oficiais em Timor-Leste: o português e o Tétum-Praça
Authors: Albuquerque Davi Borges de , Taylor-Leech Kerry
Published: October 2020

O presente artigo tem como objetivo analisar a política e o planejamento linguísticos para o português e o Tétum-Praça em Timor-Leste, já que ambas as línguas são asseguradas pela constituição do país, que data de 2002, como línguas oficiais. Desta forma, em (2), serão discutidos o alçamento do status e do corpus do Tétum-Praça; em (3), será examinada principalmente a questão do status da língua portuguesa em território leste-timorense; e, em (4), serão elaboradas grades de análise para avaliar a eficácia do planejamento linguístico leste-timorense em diferentes momentos de sua história.
O "grand tour" e o "risorgimento": imaginários românticos da Itália na literatura francesa
Authors: Mello Celina Maria Moreira de
Published: October 2020

Neste ensaio, serão comentados alguns relatos de escritores-viajantes franceses do século XIX, que, na tradição do grand tour, descrevem, em quadros textuais e ecfrasis, um imaginário de beleza plástica voltado para cenas e paisagens italianas. Destacam-se em algumas passagens de Voyage en Italie, de Chateaubriand, Prome­nades dans Rome, de Stendhal e, da Voyage en Italie, de Théophile Gautier seu contexto histórico relativo às lutas pela unificação da Itália, observando-se a construção de um olhar sobre o outro, de acordo com diferentes estéticas, neoclássica, moderna e romântica, diversos gêne­ros picturais, pintura de história, cenas de gênero e paisagens e gêneros literários: carta e memórias, guias e narrativas jornalísticas de viagem. Para enfatizar a relação entre imaginários pinturescos da arte e da literatura e a projeção de espaços políticos, é feito o contraponto com um olhar “outro”, o de George Sand e Alexandre Dumas.
A ecocrítica queer de Elizabeth Bishop no "Bras/zil"
Authors: Ávila Eliana
Published: October 2020

Demonstra-se que, ao lado das reservas explícitas de Elizabeth Bishop contra a lógica essencialista de gênero, ela elaborou uma poética anti-essencialista de gênero para engajar a vulnerabilidade de seu posicionamento enquanto poeta do cânone anglo­-americano que inevitavelmente, porque histori­camente, representou a voz e o olhar fabricadores do sujeito soberano sobre o Brasil. Propõe-se uma leitura ecocrítica do conflito entre a recusa de uma identidade de gênero para a voz lírica, no poema “Brazil, January 1, 1502”, e a atribuição de uma identidade geopolítica engendrada para o outro. O objetivo do artigo é duplo: considerar o que acon­tece quando se desestabiliza o discurso normativo de gêneros geopolíticos; e, finalmente, contribuir para o debate, proposto por Silviano Santiago, sobre o valor ético dos textos que representam o olhar de Bishop sobre o Brasil.
Trânsitos afetivos na poesia contemporânea: cartografias, relevos e percursos
Authors: Di Leone Luciana María
Published: October 2020

Este texto pretende indagar sobre a forte presença de trabalhos artísticos, especialmente na poesia contemporânea, que apresentam uma cena de es­crita e leitura relacional e coletiva, que abre as no­ções de voz e subjetividade próprias aos encontros de afetação mútua com o outro. Tomando para isso e como fio condutor o trabalho de Marília Garcia, procuro me deter em alguns elementos paradig­máticos de uma poética dos afetos. Em primeiro lugar, na explicitação do próprio trabalho como um movimento permanente de escrita da leitura que, ao mesmo tempo, é resultado das leituras e encontros com poetas/amigos e a eles se endereça. Em seguida, na evidenciação da impossibilidade de um desenvolvimento pleno e sem atritos desse circuito, ou seja, da falha da correspondência entre a leitura e a escrita, entre representação e referente (conflito observado no trabalho sobre as cartografias). Por último, na construção delibera­da da obra como um percurso pautado pelos en­contros afetivos como momentos conflitantes, que performam criticamente essas falhas, projetando intervenções na cartografia que desestabilizam toda possibilidade de localização, mas ao mesmo tempo criam espaços de pertencimento.
A emergência do sujeito desejante no discurso do MST
Authors: Indursky Freda
Published: October 2020

No presente trabalho, retorno às designações ocupação/ invasão para examinar um registro muito peculiar da designação invasão, ocorrido em uma entrevista com Diolinda Alves de Souza, líder do MST, em 06/12/1995, para a Revista da Folha. Interessou- me, nesta entrevista, examinar o processo de subjetivação/identificação de Diolinda: em um determinado momento da referida entrevista, ao responder sobre sua primeira ocupação, refere-a como invasão. Assim procedendo, a entrevistada não mobiliza o que o sujeito pode/deve dizer a partir de seu lugar discursivo. Esta designação não corresponde ao modo de subjetivar-se Formação Discursiva Sem Terra, tão bem desenhado ao longo da entrevista, até aquele momento. Esse deslizamento de ocupação para invasão permite identificar um processo metafórico específico. Processo metafórico é “um processo não-subjetivo no qual o sujeito se constitui” (Pêcheux, 1988, p. 130). E ainda: processo de metáfora consiste em um “processo sócio-histórico que serve como fundamento da ´apresentação´ de objetos para os sujeitos” (idem, p. 132). Entendo que este processo metafórico específico aqui analisado permite vislumbrar o momento em que o sujeito do discurso político é lançado em suas memórias de onde emerge como um sujeito desejante.
Identificação, memória e figuras identitárias: a tensão entre a cristalização e o deslocamento de lugares sociais
Authors: Grigoletto Evandra , Nardi Fabiele Stockmans De
Published: October 2020

A proposta deste artigo é discutir a noção de figuras identitárias, observando como a memória intervém no processo de produção de sentidos, promovendo a cristalização e/ou o deslocamento de determinados lugares sociais. Essa noção se apoia no conceito de figura, que tomamos aqui enquanto cristalização, no tempo, de uma imagem que está colada à representação de um lugar social. A figura aparece como forma por meio da qual é possível representar esse lugar, podendo sofrer deslocamentos ao ser discursivizada em diferentes épocas. Trata-se da forma material de um discurso fundador (ORLANDI, 2003) que marca o imaginário que se constrói sobre um grupo social. Ao ocuparmo-nos das figuras identitárias, traçamos como objetivos centrais deste artigo: 1) produzir uma teorização acerca dessa noção no campo da AD, a partir da relação entre os conceitos de figura, memória e identificação; 2) explorar a sua produtividade analítica, a partir das figuras do cangaceiro e do compadrito.
(De)Composições do corpo físico e social: a emergência do zumbi na ficção norte-americana contemporânea
Authors: Gomes Anderson Soares
Published: October 2020

Um dos mais populares monstros do período contemporâneo, o zumbi se configura como significante privilegiado para captar as ansiedades do início do século XXI. Surgido nas narrativas de viagem de exploradores do Haiti no início do século XX, e depois adquirindo status de principal criatura do cinema de horror da atualidade, o zumbi vem servindo como alegoria para autores da literatura norte-americana tematizarem discussões sobre os limites da civilização, do corpo, e da própria noção de self. O presente trabalho se concentra em dois romances essenciais para melhor compreender o zumbi como símbolo da (de)composição do mundo contemporâneo. O primeiro é Zone One, de Colson Whitehead, que mostra a tentativa de reconstrução da cidade de Nova York após a infestação da cidade pelas criaturas. O romance também apresenta uma variação bastante peculiar e complexa do zumbi: o straggler. A segunda obra aqui discutida é Guerra Mundial Z, de Max Brooks, que traça um mosaico de personagens e narra os acontecimentos de uma guerra contra zumbis que praticamente extinguiu a humanidade. Os dois romances discutem, em suas narrativas, como o zumbi problematiza noções de alteridade por ser uma criatura despida de subjetividade, mas que ainda assim preserva traços humanos. Além disso, os mortos-vivos servem como exemplo máximo para o conceito de "estranho" (unheimlich), como analisado por Freud. Assim sendo, este trabalho pretende investigar a ascensão do zumbi como metáfora do momento atual na literatura norte-americana contemporânea e  discutir  como esse monstro tão assustador serve como representação do zeitgeist deste início de século.