bluuebunny/crossref_metadata_2025 huggingface dataset:
RETRACTED ARTICLE: Discontinuation of medications classified as reuptake inhibitors affects treatment response of MDMA-assisted psychotherapy
Authors: Feduccia Allison A. , Jerome Lisa , Mithoefer Michael C. , Holland Julie
Published: November 2020

Rationale

MDMA-assisted psychotherapy is under investigation as a novel treatment for posttraumatic stress disorder (PTSD). The primary mechanism of action of MDMA involves the same reuptake transporters targeted by antidepressant medications commonly prescribed for PTSD.

Objectives

Data were pooled from four phase 2 trials of MDMA-assisted psychotherapy. To explore the effect of tapering antidepressant medications, participants who had been randomized to receive active doses of MDMA (75–125 mg) were divided into two groups (taper group (n = 16) or non-taper group (n = 34)).

Methods

Between-group comparisons were made for PTSD and depression symptom severity at the baseline and the primary endpoint, and for peak vital signs across two MDMA sessions.

Results

Demographics, baseline PTSD, and depression severity were similar between the taper and non-taper groups. At the primary endpoint, the non-taper group (mean = 45.7, SD = 27.17) had a significantly (p = 0.009) lower CAPS-IV total scores compared to the taper group (mean = 70.3, SD = 33.60). More participants in the non-taper group (63.6%) no longer met PTSD criteria at the primary endpoint than those in the taper group (25.0%). The non-taper group (mean = 12.7, SD = 10.17) had lower depression symptom severity scores (p = 0.010) compared to the taper group (mean = 22.6, SD = 16.69). There were significant differences between groups in peak systolic blood pressure (p = 0.043) and diastolic blood pressure (p = 0.032).

Conclusions

Recent exposure to antidepressant drugs that target reuptake transporters may reduce treatment response to MDMA-assisted psychotherapy.
Improvement of late gadolinium enhancement image quality using a deep learning–based reconstruction algorithm and its influence on myocardial scar quantification
Authors: van der Velde Nikki , Hassing H. Carlijne , Bakker Brendan J. , Wielopolski Piotr A. , Lebel R. Marc , Janich Martin A. , Kardys Isabella , Budde Ricardo P. J. , Hirsch Alexander
Published: November 2020

Objectives

The aim of this study was to assess the effect of a deep learning (DL)–based reconstruction algorithm on late gadolinium enhancement (LGE) image quality and to evaluate its influence on scar quantification.

Methods

Sixty patients (46 ± 17 years, 50% male) with suspected or known cardiomyopathy underwent CMR. Short-axis LGE images were reconstructed using the conventional reconstruction and a DL network (DLRecon) with tunable noise reduction (NR) levels from 0 to 100%. Image quality of standard LGE images and DLRecon images with 75% NR was scored using a 5-point scale (poor to excellent). In 30 patients with LGE, scar size was quantified using thresholding techniques with different standard deviations (SD) above remote myocardium, and using full width at half maximum (FWHM) technique in images with varying NR levels.

Results

DLRecon images were of higher quality than standard LGE images (subjective quality score 3.3 ± 0.5 vs. 3.6 ± 0.7, p < 0.001). Scar size increased with increasing NR levels using the SD methods. With 100% NR level, scar size increased 36%, 87%, and 138% using 2SD, 4SD, and 6SD quantification method, respectively, compared to standard LGE images (all p values < 0.001). However, with the FWHM method, no differences in scar size were found (p = 0.06).

Conclusions

LGE image quality improved significantly using a DL-based reconstruction algorithm. However, this algorithm has an important impact on scar quantification depending on which quantification technique is used. The FWHM method is preferred because of its independency of NR. Clinicians should be aware of this impact on scar quantification, as DL-based reconstruction algorithms are being used.

Key Points

• The image quality based on (subjective) visual assessment and image sharpness of late gadolinium enhancement images improved significantly using a deep learning–based reconstruction algorithm that aims to reconstruct high signal-to-noise images using a denoising technique.

• Special care should be taken when scar size is quantified using thresholding techniques with different standard deviations above remote myocardium because of the large impact of these advanced image enhancement algorithms.

• The full width at half maximum method is recommended to quantify scar size when deep learning algorithms based on noise reduction are used, as this method is the least sensitive to the level of noise and showed the best agreement with visual late gadolinium enhancement assessment.
Retrospective evaluation of attempted vaginal deliveries in dichorionic twin pregnancies
Authors: Enengl Sabine , Oppelt Peter , Enzelsberger Simon-Hermann , Trautner Philip Sebastian , Shebl Omar , Brandl Birgit , Mayer Richard Bernhard
Published: November 2020

Purpose

Numbers of planned cesarean deliveries are increasing in twin pregnancies, despite the lack of evidence for this approach, and the second twin is thought to be at risk for a poorer outcome. The aim of this study was to examine whether twins have a poorer outcome if an attempted vaginal delivery is changed to a cesarean section or combined delivery.

Methods

This retrospective data analysis included all women with dichorionic twin pregnancies attempting vaginal delivery over a 10-year period. Outcome parameters for the first and second twins relative to their mode of birth were compared. A correlation model between the interdelivery time interval and Apgar scores was calculated. Subgroup analyses assessing the birth mode of the first and second twins were conducted.

Results

A total of 248 women were enrolled in the study. The second twins had significantly lower values for outcome parameters, such as umbilical artery cord pH and Apgar scores in comparison with the first twins (P < 0.01). The subgroup analysis of birth modes in first and second twins showed a significantly poorer outcome in the cesarean section and combined delivery group (P < 0.05). The interdelivery time interval was significantly longer in the second twin cesarean section group (P < 0.01). There was no significant correlation between the interdelivery time intervals and Apgar scores (P > 0.05).

Conclusion

Although outcome parameters were significantly lower in second twins and twins born via secondary cesarean section, the clinical relevance of this appears to be negligible.
Acute and sub-acute toxicity profile of ultra-hypofractionated low-dose total skin electron beam with two 4 Gy fractions for cutaneous T cell lymphoma
Authors: Rolf Daniel , Elsayad Khaled , Eich Hans Theodor
Published: November 2020

Purpose

Low-dose total skin electron beam therapy (TSEBT) over 3 weeks has proved to be a safe and effective treatment for cutaneous T cell lymphomas (CTCL). In this prospective trial, we examined the feasibility of ultra-hypofractionated low-dose TSEBT regimen in two fractions with 4 Gy combined with systemic therapy to minimize the number of visits to radiation centers.

Patients and methods

Six patients with mycosis fungoides (MF) or Sézary syndrome (SS) received TSEBT with a total radiation dose of 8 Gy in two fractions between April 2020 and June 2020. Patient and treatment characteristics, tumor burden, the impact on the quality of life using Skindex-29 questionnaires, and acute toxicities were analyzed.

Results

During TSEBT, all patients developed grade 1 toxicities while two patients developed grade 2 toxicities. One patient experienced sepsis. The most common adverse effects were erythema and edema. All grade 2 toxicities regressed after 4 weeks following TSEBT. Based on the reported symptoms measured by Skindex-29, we detected a significant reduction in total Skindex-29 score after 8 weeks of radiation (P = 0.03), particularly in the symptoms (P = 0.01) and emotional domains (P = 0.04).

Conclusion

Ultra-hypofractionated low-dose TSEBT followed by systemic therapy seems to be a safe and feasible alternative to conventional fractionated TSEBT for patients with MF/SS. The skin tumor burden and the health-related quality of life have been significantly improved within 8 weeks following radiotherapy.
Intraspecific drought tolerance of Betula pendula genotypes: an evaluation using leaf turgor loss in a botanical collection
Authors: Hannus Simon , Hirons Andrew , Baxter Timothy , McAllister Hugh A. , Wiström Björn , Sjöman Henrik
Published: November 2020

Key message

The results showed a significant relationship between the potential evapotranspiration of the provenance collection site and the leaf turgor loss point and significant positive differences in drought tolerance between provenances and subspecies of B. pendula.

The ecosystem services provided by urban trees make substantial contributions to the quality of urban living and securing resilience towards the challenges posed by a changing climate. Water deficits are a major abiotic stress for trees in urban environments and, in many regions, this stress is likely to be amplified under future climate scenarios. Although wide variation in drought tolerance exists at the species level, many species also show substantial intraspecific variation in drought tolerance. The aim of this study is to evaluate how drought tolerance, inferred from the water potential at leaf turgor loss point (ΨP0), varies in Betula pendula from different geographical origins and determine if the observed drought tolerance can be related to the local climate and seasonal water balance from the provenance of origin, despite the trees now being established in similar soil and climatic conditions within a single botanical collection. Six subsp. betula, five subsp. mandshurica and two subsp. szechuanica were evaluated, giving a total of 12 different provenances. The results showed a significant relationship between the potential evapotranspiration of the provenance collection site and the leaf turgor loss point and significant positive differences in drought tolerance between provenances and subspecies of B. pendula. By directing efforts towards identifying more drought-tolerant genotypes, it will be possible to diversify the palette of trees that could confidently be integrated by urban tree planners and landscape architects into the urban landscape. The results of this study on different ecotypes of B. pendula clearly show that it is possible to find more drought-tolerant plant material.
Epidemiological trends, predictive factors, and projection of tooth loss in Germany 1997–2030: part I. missing teeth in adults and seniors
Authors: Jordan A. Rainer , Stark H. , Nitschke I. , Micheelis W. , Schwendicke F.
Published: November 2020

Objective

This is the first part of a report on tooth loss in Germany 1997–2030. Here, we describe trends in the prevalence of tooth loss in adults and seniors 1997–2014, assess predictive factors for tooth loss and projected it into 2030.

Material and methods

Data of the cross-sectional, multi-center, nationally representative German Oral Health Studies of 1997, 2005, and 2014 were used. Age, sex, educational level, smoking status, and the cohort were used for ordinary least square regression to assess the association of predictors with tooth loss (missing teeth, MT). The yielded regression coefficients were used to predict tooth loss in 2030.

Results

Compared with 1997, the mean MT in adults (35–44 years old) in 2030 was predicted to decrease by two-thirds to 1.3. The prevalence of tooth loss (MT > 0) will decrease by 72% from 1997 to 2030. In 2030, half of the population of adults will not exhibit any tooth loss. Compared with 1997, the mean MT among seniors (65–74 years old) will decline to 5.6 teeth (i. e. two-thirds reduction) until 2030. Prevalence of tooth loss will be halved by 2030, and approximately one-third of this age group will not exhibit any tooth loss.

Conclusions

Based on the model used, the trend of a robust decline in tooth loss will become more dynamic by the year 2030. As a result, every second adult will have experienced no tooth loss at all in 2030, and seniors will possess more teeth than they have previously lost.

Clinical relevance

This study presents the trends of tooth loss in Germany for a period of three decades. It provides clinically relevant data for health care planning by 2030.
The role of mechanics in the growth and homeostasis of the intestinal crypt
Authors: Almet A. A. , Byrne H. M. , Maini P. K. , Moulton D. E.
Published: November 2020

We present a mechanical model of tissue homeostasis that is specialised to the intestinal crypt. Growth and deformation of the crypt, idealised as a line of cells on a substrate, are modelled using morphoelastic rod theory. Alternating between Lagrangian and Eulerian mechanical descriptions enables us to precisely characterise the dynamic nature of tissue homeostasis, whereby the proliferative structure and morphology are static in the Eulerian frame, but there is active migration of Lagrangian material points out of the crypt. Assuming mechanochemical growth, we identify the necessary conditions for homeostasis, reducing the full, time-dependent system to a static boundary value problem characterising a spatially heterogeneous “treadmilling” state. We extract essential features of crypt homeostasis, such as the morphology, the proliferative structure, the migration velocity, and the sloughing rate. We also derive closed-form solutions for growth and sloughing dynamics in homeostasis, and show that mechanochemical growth is sufficient to generate the observed proliferative structure of the crypt. Key to this is the concept ofthreshold-dependentmechanical feedback, that regulates an established Wnt signal for biochemical growth. Numerical solutions demonstrate the importance of crypt morphology on homeostatic growth, migration, and sloughing, and highlight the value of this framework as a foundation for studying the role of mechanics in homeostasis.
Optimization of n-butanol synthesis in Lactobacillus brevis via the functional expression of thl, hbd, crt and ter
Authors: Li Qi , Wu Meixian , Wen Zhiqiang , Jiang Yuan , Wang Xin , Zhao Yawei , Liu Jinle , Yang Junjie , Jiang Yu , Yang Sheng
Published: November 2020

N-butanol is an important chemical and can be naturally synthesized by Clostridium species; however, the poor n-butanol tolerance of Clostridium impedes the further improvement in titer. In this study, Lactobacillus brevis, which possesses a higher butanol tolerance, was selected as host for heterologous butanol production. The Clostridium acetobutylicum genes thl, hbd, and crt which encode thiolase, β-hydroxybutyryl-CoA dehydrogenase, and crotonase, and the Treponema denticola gene ter, which encodes trans-enoyl-CoA reductase were cloned into a single plasmid to express the butanol synthesis pathway in L. brevis. A titer of 40 mg/L n-butanol was initially achieved with plasmid pLY15-opt, in which all pathway genes are codon-optimized. A titer of 450 mg/L of n-butanol was then synthesized when ter was further overexpressed in this pathway. The role of metabolic flux was reinforced with pLY15, in which only the ter gene was codon-optimized, which greatly increased the n-butanol titer to 817 mg/L. Our strategy significantly improved n-butanol synthesis in L. brevis and the final titer is the highest achieved amongst butanol-tolerant lactic acid bacteria.

Graphic abstract
Understanding client satisfaction in elderly care: new insights from social resource theory
Authors: Kazemi Ali , Kajonius Petri J.
Published: November 2020

Social resource theory suggests that social interaction can be conceived as resource transaction or exchange with behaviours falling within six fundamental resource categories (i.e. love, status, information, money, goods, and services) organised along two underlying dimensions: particularism–universalism and concreteness–abstractness. With the purpose of extending knowledge about quality of care, this study adopts a novel approach in that it describes and categorises care behaviours using social resource theory instead of using single instances of care behaviour. The categorisation is further used to predict client satisfaction in care services targeting older people. Daily interactions between care staff and older persons were observed in two different residential care facilities using a structured non-participant observation design. The data were analysed using principal component analysis, correlation, and regression analysis. The results confirmed the hypothesis that satisfaction with care services is predicted by resource transactions that are high on the underlying dimensions of particularism and abstractness. Thus, the resource categories of love and status (resource categories high on particularism and abstractness) were shown to be strong predictors of client satisfaction. The use of social resource theory is a novel and appropriate approach to examine person-centred care and satisfaction with care. Also, in addition to addressing potential problems in previous self-report studies on care staff behaviour, the observational technique was highly practical to this service area where dealing with clients not always able to provide feedback directly.
Noise analysis and optimization of VCII-based SiPM interface circuit
Authors: Ferri G. , Safari L. , Barile G. , Pantoli L. , Stornelli V.
Published: November 2020

Recently, second generation voltage conveyor (VCII)-based transimpedance amplifiers (TIAs) have begun to find their way in different applications, among which, silicon photomultipliers (SiPMs) interfacing circuitry. There are many advantages which make VCII-based TIAs attractive over conventional circuits: the intrinsic low impedance at VCII current input Y port is very helpful to mitigate the effect of high value sensor capacitance and provides fast response time; the achieved bandwidth is high and due to current mode operation; the circuits enjoy the low-voltage low-power features. As signal-to-noise ratio is a crucial parameter in SiPMs interface circuit applications, here we consider the noise specifications and optimization of VCII-based SiPM interface circuits. The noise model of VCII is introduced and equivalent noise of a VCII-based interface circuit is derived. Methods to optimize trade-offs existing between key parameters including power consumption, gain and noise performance are discussed. Simulation results are also provided showing a considerable reduction of two orders of magnitude in most of the noise performances when compared to the previous work while preserving other performance parameters.
Gendered impacts of greenhouse gas mitigation options for rice cultivation in India
Authors: Gartaula Hom , Sapkota Tek B , Khatri-Chhetri Arun , Prasad Gokul , Badstue Lone
Published: November 2020

The nexus of gender-agriculture-emissions reduction is one of the least explored areas related to agriculture and climate change. This nexus plays an important role in the areas where women’s participation in agriculture is high, and the contribution of the agricultural sector to total emission is significant. This study generates evidence on women’s labor contribution in rice cultivation and potential reduction of their labor drudgery, including GHG mitigation co-benefits with the adoption of direct seeding and machine transplanting technologies. Using a large number of plot-level data (11,987 data points) from the rice-growing regions of India, the study shows that changing rice production technology from conventional to direct-seeded rice (DSR) and/or machine-transplanted rice (MTR) offers huge potential to reduce women’s labor in rice planting (745 million labor-days for DSR and 610 million labor-days for MTR) and greenhouse gases (GHG) emission (34 MtCO2e for DSR and 7 MtCO2e for MTR) at the same time. This potential differs from the agro-ecological region, the level of input use, and women’s involvement in rice cultivation. The realization of this gender-responsive GHG mitigation strategy depends on the adoption of these technologies, which rely on several social, economic, and political factors. At the same time, the immense potential for negative implications for some specific groups should not be ignored, but focused on addressing and mitigating those challenges.
The Malmö Offspring Study (MOS): design, methods and first results
Authors: Brunkwall Louise , Jönsson Daniel , Ericson Ulrika , Hellstrand Sophie , Kennbäck Cecilia , Östling Gerd , Jujic Amra , Melander Olle , Engström Gunnar , Nilsson Jan , Ohlsson Bodil , Klinge Björn , Orho-Melander Marju , Persson Margaretha , Nilsson Peter M.
Published: November 2020

As cardio metabolic disease manifestations tend to cluster in families there is a need to better understand the underlying mechanisms in order to further develop preventive strategies. In fact, genetic markers used in genetic risk scores, important as they are, will not be able alone to explain these family clusters. Therefore, the search goes on for the so called missing heritability to better explain these associations. Shared lifestyle and social conditions in families, but also early life influences may be of importance. Gene-environmental interactions should be explored. In recent years interest has grown for the role of diet-microbiota associations, as microbiota patterns may be shared by family members. In the Malmö Offspring Study that started in 2013, we have so far been able to examine about 4700 subjects (18–71 years) representing children and grandchildren of index subjects from the first generation, examined in the Malmö Diet Cancer Study during 1991 to 1996. This will provide rich data and opportunities to analyse family traits of chronic disease across three generations. We will provide extensive genotyping and phenotyping including cardiovascular and respiratory function, as well as markers of glucose metabolism. In addition, also cognitive function will be assessed. A 4-day online dietary recall will be conducted and gut as well as oral microbiota analysed. The ambition is to provide one of the first large-scale European family studies with individual data across three generations, which could deepen our knowledge about the role of family traits for chronic disease and its underlying mechanisms.
Vegetation height estimation using ubiquitous foot-based wearable platform
Authors: Nasim Sofeem , Oussalah Mourad , Klöve Bjorn , Haghighi Ali Torabi
Published: November 2020

Vegetation height plays a key role in many environmental applications such as landscape characterization, conservation planning and disaster management, and biodiversity assessment and monitoring. Traditionally, in situ measurements and airborne Light Detection and Ranging (LiDAR) sensors are among the commonly employed methods for vegetation height estimation. However, such methods are known for their high incurred labor, time, and infrastructure cost. The emergence of wearable technology offers a promising alternative, especially in rural environments and underdeveloped countries. A method for a locally designed data acquisition ubiquitous wearable platform has been put forward and implemented. Next, a regression model to learn vegetation height on the basis of attributes associated with a pressure sensor has been developed and tested. The proposed method has been tested in Oulu region. The results have proven particularly effective in a region where the land has a forestry structure. The linear regression model yields (r2 = 0.81 and RSME = 16.73 cm), while the use of a multi-regression model yields (r2 = 0.82 and RSME = 15.73 cm). The developed approach indicates a promising alternative in vegetation height estimation where in situ measurement, LiDAR data, or wireless sensor network is either not available or not affordable, thus facilitating and reducing the cost of ecological monitoring and environmental sustainability planning tasks.
Investigation of the influence of impurities on the ring-opening polymerisation of L-Lactide from biogenous feedstock
Authors: Itzinger Regina , Schwarzinger Clemens , Paulik Christian
Published: November 2020

In order to use a L-lactide monomer that is derived from fermentation processes it is necessary to understand, how the polymerisation process is influenced by impurities which derive from the production process. We have selected a group of likely contaminants and added them at various concentrations to the polymerisation of L-lactide using tin (II)-2-ethylhexanoate as catalyst and 2-methoxyethanol as initiator. The effect of impurities onto the global properties of the polymers such as glass transition temperature, melting point and molecular mass distribution were investigated and NMR and MALDI mass spectrometry were used to identify structural changes within the polymers. Thus, it could be shown that in reference experiments cyclic polymers and linear polymers with different starting groups are formed. Addition of ethanol and sodium carbonate showed the strongest influence on molecular masses as well as polymer structures, which could be elucidated by interpretation of the MALDI mass spectra and NMR data.
Large carabids enhance weed seed removal in organic fields and in large-scale, but not small-scale agriculture
Authors: Fischer Christina , Riesch Friederike , Tscharntke Teja , Batáry Péter
Published: November 2020

Context

Biological weed control by seed predators is an ecosystem service reducing weed population densities in agricultural landscapes. Drivers of seed predation are manifold and may change with spatial scales considered.

Objectives

We aimed at identifying the functional identity of seed predators, food web interactions and feeding links between weed and wheat seeds, considering the causal relationships between local and landscape-scale patterns.

Methods

We investigated direct and indirect effects of local management intensity in winter wheat fields (organic vs. conventional farming), local crop characteristics (wheat density and height), edge effects, landscape composition (measured as land-use diversity) and configuration (edge length) on carabid beetles of different body size (large vs. small carabids), and removal of weed and wheat seeds.

Results

We showed the importance of indirect local- and landscape-scale effects for weed seed removal via the activity density, but not assemblage composition, of large, but not small carabids, which was driven by few ubiquitous species. The activity density of large carabids increased with decreasing wheat density and increasing wheat height, which was highest in organic fields and in landscapes with low compositional and configurational heterogeneity. Further, the availability of nutrient-rich wheat seeds enhanced weed seed removal rates.

Conclusions

We found highest weed seed removal via large carabids in organic fields in large-scale agricultural landscapes. Predator body size and species identity as well as the availability of additional food items need to be taken into account for better predicting the biological weed control potential and reducing the use of plant protection products.
Evaluating the effectiveness of clinical ethics committees: a systematic review
Authors: Crico Chiara , Sanchini Virginia , Casali Paolo Giovanni , Pravettoni Gabriella
Published: November 2020

Clinical Ethics Committees (CECs), as distinct from Research Ethics Committees, were originally established with the aim of supporting healthcare professionals in managing controversial clinical ethical issues. However, it is still unclear whether they manage to accomplish this task and what is their impact on clinical practice. This systematic review aims to collect available assessments of CECs’ performance as reported in literature, in order to evaluate CECs’ effectiveness. We retrieved all literature published up to November 2019 in six databases (PubMed, Ovid MEDLINE, Scopus, Philosopher’s Index, Embase and Web of Science), following PRISMA guidelines. We included only articles specifically addressing CECs and providing any form of CECs performance assessment. Twenty-nine articles were included. Ethics consultation was the most evaluated of CECs’ functions. We did not find standardized tools for measuring CECs’ efficacy, but 33% of studies considered “user satisfaction” as an indicator, with 94% of them reporting an average positive perception of CECs’ impact. Changes in patient treatment and a decrease of moral distress in health personnel were reported as additional outcomes of ethics consultation. The highly diverse ways by which CECs carry out their activities make CECs’ evaluation difficult. The adoption of shared criteria would be desirable to provide a reliable answer to the question about their effectiveness. Nonetheless, in general both users and providers consider CECs as helpful, relevant to their work, able to improve the quality of care. Their main function is ethics consultation, while less attention seems to be devoted to bioethics education and policy formation.
Disentangling succession and entrepreneurship gender gaps: gender norms, culture, and family
Authors: Feldmann Manuel , Lukes Martin , Uhlaner Lorraine
Published: November 2020

This study adapts a multi-level view of culture, including society- and family-based gender norms and the family embeddedness perspective, to predict the career status of a sample of 2897 young Europeans (aged 18–35) from 11 countries, with at least one self-employed parent. We find that gender identity is associated with career status such that a woman is more likely than a man to be an employee vs. a successor to a family firm but no less likely to be a founder as compared with either being an employee or successor. However, certain family and society-level culture variables combined with gender identity reverse these trends. A woman with caring responsibilities is more likely to be a successor than either a founder or employee. Also, while two-way interaction effects for traditional gender norms and having a self-employed mother are weak or not significant, the study finds that in combination, a woman reporting both traditional gender norms and having a self-employed mother is more likely to be a successor than being either an employee or a founder, reversing gender identity main effects. Incorporating the family embeddedness perspective and the role of culture in occupational choice, we develop a better view of the gender gap in entrepreneurship, finding that the family may serve as a stronger influence than society when implied norms of these two levels of culture clash. By examining actual rather than intended career choice, we also contribute to the occupational choice literature on youth employment.
Women entrepreneurs’ progress in the venturing process: the impact of risk aversion and culture
Authors: Gimenez-Jimenez Daniela , Edelman Linda F. , Dawson Alexandra , Calabrò Andrea
Published: November 2020

We explore the gendered impact of risk aversion and country-level culture on nascent student entrepreneurs’ progress in the venturing process. Combining country-level cultural normative variables from the 2004 Global Leadership and Organizational Behavior Effectiveness (GLOBE) survey with data from the 2013/2014 Global University Entrepreneurial Student Spirit Study (GUESSS), our sample consists of 1552 nascent student entrepreneurs from 11 countries. We start with the assumption that perceptions of risk-taking behaviors are not gendered. We then split our sample, finding that, for women, perceptions of risk-taking behaviors are associated with less progress in the venturing process; however, starting a new venture in a socially supportive culture moderates that relationship. For men, neither risk-taking behavior nor country cultural variables are related to their progress in the venturing process. Our study highlights both the importance of country-level contextual variables in entrepreneurship and the need to employ a gendered perspective when studying nascent entrepreneurship.
Applying advanced technologies to improve clinical trials: a systematic mapping study
Authors: Ngayua Esther Nanzayi , He Jianjia , Agyei-Boahene Kwabena
Published: November 2020

The increasing demand for new therapies and other clinical interventions has made researchers conduct many clinical trials. The high level of evidence generated by clinical trials makes them the main approach to evaluating new clinical interventions. The increasing amounts of data to be considered in the planning and conducting of clinical trials has led to higher costs and increased timelines of clinical trials, with low productivity. Advanced technologies including artificial intelligence, machine learning, deep learning, and the internet of things offer an opportunity to improve the efficiency and productivity of clinical trials at various stages. Although researchers have done some tangible work regarding the application of advanced technologies in clinical trials, the studies are yet to be mapped to give a general picture of the current state of research. This systematic mapping study was conducted to identify and analyze studies published on the role of advanced technologies in clinical trials. A search restricted to the period between 2010 and 2020 yielded a total of 443 articles. The analysis revealed a trend of increasing research interests in the area over the years. Recruitment and eligibility aspects were the main focus of the studies. The main research types were validation and evaluation studies. Most studies contributed methods and theories, hence there exists a gap for architecture, process, and metric contributions. In the future, more empirical studies are expected given the increasing interest to implement the AI, ML, DL, and IoT in clinical trials.
Environmental risk assessment of priority biocidal substances on Polish surface water sample
Authors: Durak Justyna , Rokoszak Tomasz , Skiba Alicja , Furman Przemysław , Styszko Katarzyna
Published: November 2020

The EU directive 2013/39/EU has incorporated four biocidal compounds as priority substances: diuron, isoproturon, cybutryne, and terbutryn. The research was undertaken to determine the concentration of biocides in surface waters in three locations in southern Poland: the Wisła River in Kraków, the Wisłoka River in Mielec, and the drainage ditch draining water from arable fields located near Mielec. Environmental samples were taken in two series: winter (February) and spring (May and June). The analyses were carried out using gas chromatography with mass spectrometry. The seasonality of biocides in surface waters was observed. In winter samples, the concentrations were below MQL, while in spring, they ranged from a few to several dozen nanograms per liter. The highest concentrations of all analyzed compounds were recorded in water taken from the Wisła River. According to directive 2013/39/EU, the maximum allowable concentration was exceeded only in the case of cybutryne in water from the Wisła, both in May and in June. The assessment of the toxicity with the tested compounds was defined based on the Environmental Risk Assessment method. Low risk was estimated for diuron and isoproturon, while moderate risk for terbutryn and cybutryne.
Thyroid hormone signaling is associated with physical performance, muscle mass, and strength in a cohort of oldest-old: results from the Mugello study
Authors: Di Iorio Angelo , Paganelli Roberto , Abate Michele , Barassi Giovanni , Ireland Alex , Macchi Claudio , Molino-Lova Raffaele , Cecchi Francesca
Published: November 2020

Thyroid hormones (THs) play a crucial role in the homeostasis of muscle function, such as myogenesis and energy metabolism, suggesting that the thyroid may be also involved in the entropic processes of muscle aging. The aim of the present study is to evaluate the effect of TH signaling on physical performance, muscle mass, and strength in a cohort of community-dwelling oldest-old subjects (> 90 years). The study population was selected in a rural area of central Italy (Mugello, Tuscany), and the design was cross-sectional. Four hundred seventy-five subjects (130 males and 345 females) were enrolled, representing about 65% of all the nonagenarians living in the Mugello area. After adjusting for multiple confounding factors (sex, age, diabetes, and levothyroxine administration), the lowest quartile of FT3/FT4 ratio distribution showed lower physical performance compared to the other quartiles (β ± SE: − 0.49 ± 0.12; p < 0.001), whereas the highest quartile of FT3/FT4 ratio was associated with higher skeletal muscle index (β ± SE: 1.11 ± 0.42; p = 0.009). In addition, the lowest quartile of FT4 showed a statistically significant higher handgrip strength (β ± SE: 1.78 ± 0.68; p = 0.009) compared to all other quartiles. This study demonstrates that nonagenarians with higher FT3/FT4 ratios had better preserved muscle function, therefore successfully overcoming the imbalance of homeostatic and entropic processes involved in muscle aging. However, we could not establish a cause-effect relationship due to the cross-sectional design of the study.
Toward reliable automatic liver and tumor segmentation using convolutional neural network based on 2.5D models
Authors: Wardhana Girindra , Naghibi Hamid , Sirmacek Beril , Abayazid Momen
Published: November 2020

Purpose

We investigated the parameter configuration in the automatic liver and tumor segmentation using a convolutional neural network based on 2.5D model. The implementation of 2.5D model shows promising results since it allows the network to have a deeper and wider network architecture while still accommodates the 3D information. However, there has been no detailed investigation of the parameter configurations on this type of network model.

Methods

Some parameters, such as the number of stacked layers, image contrast, and the number of network layers, were studied and implemented on neural networks based on 2.5D model. Networks are trained and tested by utilizing the dataset from liver and tumor segmentation challenge (LiTS). The network performance was further evaluated by comparing the network segmentation with manual segmentation from nine technical physicians and an experienced radiologist.

Results

Slice arrangement testing shows that multiple stacked layers have better performance than a single-layer network. However, the dice scores start decreasing when the number of stacked layers is more than three layers. Adding higher number of layers would cause overfitting on the training set. In contrast enhancement test, implementing contrast enhancement method did not show a statistically significant different to the network performance. While in the network layer test, adding more layers to the network architecture does not always correspond to the increasing dice score result of the network.

Conclusions

This paper compares the performance of the network based on 2.5D model using different parameter configurations. The result obtained shows the effect of each parameter and allow the selection of the best configuration in order to improve the network performance in the application of automatic liver and tumor segmentation.
Delegation of implementation in project aid
Authors: Marchesi Silvia , Masi Tania
Published: November 2020

In this paper we explore the factors that determine delegation of implementation in project aid. In particular, focusing on the importance of informational asymmetry between levels of government, we empirically assess whether this choice is influenced by the relative importance of the local information at the recipient country level. Moreover, we test whether this choice can in turn influence project performance. Using information on more than 5800 World Bank projects for the period 1995-2014, and controlling for characteristics at both country and project level, we find that transparency does influence the probability that a project is implemented locally rather than nationally. More specifically, a one standard deviation decline in transparency increases the probability of a locally implemented project by three percentage points. We also find that a local implementing agency may increase the probability of a successful project only up to a certain level of a country’s transparency.
Potential of performance improvement of concentrated solar power plants by optimizing the parabolic trough receiver
Authors: Yang Honglun , Wang Qiliang , Cao Jingyu , Pei Gang , Li Jing
Published: November 2020

This paper proposes a comprehensive thermodynamic and economic model to predict and compare the performance of concentrated solar power plants with traditional and novel receivers with different configurations involving operating temperatures and locations. The simulation results reveal that power plants with novel receivers exhibit a superior thermodynamic and economic performance compared with traditional receivers. The annual electricity productions of power plants with novel receivers in Phoenix, Sevilla, and Tuotuohe are 8.5%, 10.5%, and 14.4% higher than those with traditional receivers at the outlet temperature of 550°C. The levelized cost of electricity of power plants with double-selective-coated receivers can be decreased by 6.9%, 8.5%, and 11.6%. In Phoenix, the optimal operating temperature of the power plants is improved from 500°C to 560°C by employing a novel receiver. Furthermore, the sensitivity analysis of the receiver heat loss, solar absorption, and freeze protection temperature is also conducted to analyze the general rule of influence of the receiver performance on power plants performance. Solar absorption has a positive contribution to annual electricity productions, whereas heat loss and freeze protection temperature have a negative effect on electricity outputs. The results indicate that the novel receiver coupled with low melting temperature molten salt is the best configuration for improving the overall performance of the power plants.
Are spliced ncRNA host genes distinct classes of lncRNAs?
Authors: Sen Rituparno , Fallmann Jörg , Walter Maria Emília M. T. , Stadler Peter F.
Published: November 2020

Many small nucleolar RNAs and many of the hairpin precursors of miRNAs are processed from long non-protein-coding host genes. In contrast to their highly conserved and heavily structured payload, the host genes feature poorly conserved sequences. Nevertheless, there is mounting evidence that the host genes have biological functions beyond their primary task of carrying a ncRNA as payload. So far, no connections between the function of the host genes and the function of their payloads have been reported. Here we investigate whether there is evidence for an association of host gene function or mechanisms with the type of payload. To assess this hypothesis we test whether the miRNA host genes (MIRHGs), snoRNA host genes (SNHGs), and other lncRNA host genes can be distinguished based on sequence and/or structure features unrelated to their payload. A positive answer would imply a functional and mechanistic correlation between host genes and their payload, provided the classification does not depend on the presence and type of the payload. A negative answer would indicate that to the extent that secondary functions are acquired, they are not strongly constrained by the prior, primary function of the payload. We find that the three classes can be distinguished reliably when the classifier is allowed to extract features from the payloads. They become virtually indistinguishable, however, as soon as only sequence and structure of parts of the host gene distal from the snoRNAs or miRNA payload is used for classification. This indicates that the functions of MIRHGs and SNHGs are largely independent of the functions of their payloads. Furthermore, there is no evidence that the MIRHGs and SNHGs form coherent classes of long non-coding RNAs distinguished by features other than their payloads.
Rock physics and geomechanical application in the interpretation of rock property trends for overpressure detection
Authors: Eyinla Dorcas S. , Oladunjoye Michael A. , Olayinka Abel I. , Bate Boris B.
Published: November 2020

One of the complexities of geomechanical study is in the classification of rock’s properties and overpressured intervals—a knowledge which is not only essential for well safety and cost-effective drilling, but crucial in evaluating exploration risk factors and ensuring a successful hydraulic fracturing program. In this study, a more robust prediction of reservoir pressure regime is presented, where the geomechanical distributions of the rock give a distinct correlation. Three wells from the Niger Delta Basin were studied using empirical equations to estimate the elastic properties, wave velocities and the rock physics parameters for each well. From the results obtained, the velocities of compressional wave (Vp) and shear wave (Vs) decrease as porosity increases. Also, a linear correlation exists between Poisson’s ratio and Vp/Vs, where both variables showed distinct behavior and similar trend serving as useful tools for lithology identification. Another significant observation is the acoustic impedance of the materials which decreases with increasing porosity. Meanwhile, the depth plot of the impedance showed divergence and scattering away from the supposed linear trend. While inhomogeneity of the rock materials and disequilibrium compaction of sediments may account for this scattering, the variation of geomechanical distributions in this study revealed that pore pressure has a first order effect on the elastic strength of formations, also, under normal pore pressure conditions, acoustic impedance increases linearly with depth.
Advertising Unhealthy Food to Children: on the Importance of Regulations, Parenting Styles, and Media Literacy
Authors: Naderer Brigitte
Published: November 2020

Purpose of Review

Childhood obesity is a global health concern. And a number of studies have indicated that food promotions affect children’s food attitudes, preferences, and food choices for foods high in fat and sugar, which potentially impacts children’s body weight development. This review showcases how children are affected by food promotions, why companies even target children with their promotional efforts, and what makes children so susceptible to promotion of unhealthy food. In addition, this review discusses how regulations, parental styles, and individual media literacy skills can help to contain the potential detrimental effects of food promotions on children’s health.

Recent Findings

The recent findings indicate that children are affected by food promotions in their preference for unhealthy food and beverages in selection tasks shortly conducted after exposure. Furthermore, results indicate significant effects of food marketing, including enhanced attitudes, preferences, and increased consumption of marketed (predominantly unhealthy) foods connected with a wide range of marketing strategies. Children are particularly vulnerable to promotional efforts and react to it strongly due to their still developing cognitive and social skills as well as their lack in inhibitory control.

This review proposes an applied focus that discusses pathways for regulators, parents, and educators. In the light of the discussed results, a large number of studies on food promotion indicate that there is need to react. In all these measures, however, it is of relevance to consider children’s developmental stages to effectively counteract and respond to the potential detrimental effects of food promotions on children’s long-term weight development.