bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of a Novel W2027L Mutation and Non-Target Site Resistance on Acetyl-CoA Carboxylase-Inhibiting Herbicides in a French Lolium multiflorum Population
Authors: Kaundun Shiv Shankhar , Downes Joe , Jackson Lucy Victoria , Hutchings Sarah-Jane , Mcindoe Eddie
Published: November 2021

Herbicides that inhibit acetyl-CoA carboxylase (ACCase) are among the few remaining options for the post-emergence control of Lolium species in small grain cereal crops. Here, we determined the mechanism of resistance to ACCase herbicides in a Lolium multiflorum population (HGR) from France. A combined biological and molecular approach detected a novel W2027L ACCase mutation that affects aryloxyphenoxypropionate (FOP) but not cyclohexanedione (DIM) or phenylpyraxoline (DEN) subclasses of ACCase herbicides. Both the wild-type tryptophan and mutant leucine 2027-ACCase alleles could be positively detected in a single DNA-based-derived polymorphic amplified cleaved sequence (dPACS) assay that contained the targeted PCR product and a cocktail of two discriminating restriction enzymes. Additionally, we identified three well-characterised I1781L, I2041T, and D2078G ACCase target site resistance mutations as well as non-target site resistance in HGR. The non-target site component endowed high levels of resistance to FOP herbicides whilst partially impacting on the efficacy of pinoxaden and cycloxydim. This study adequately assessed the contribution of the W2027L mutation and non-target site mechanism in conferring resistance to ACCase herbicides in HGR. It also highlights the versatility and robustness of the dPACS method to simultaneously identify different resistance-causing alleles at a single ACCase codon.
Characteristics Associated with Tumor Development in Individuals Diagnosed with Beckwith–Wiedemann Spectrum: Novel Tumor-(epi)Genotype-Phenotype Associations in the BWSp Population
Authors: Duffy Kelly A. , Getz Kelly D. , Hathaway Evan R. , Byrne Mallory E. , MacFarland Suzanne P. , Kalish Jennifer M.
Published: November 2021

Beckwith–Wiedemann Spectrum (BWSp) is the most common epigenetic childhood cancer predisposition disorder. BWSp is caused by (epi)genetic changes affecting the BWS critical region on chromosome 11p15. Clinically, BWSp represents complex molecular and phenotypic heterogeneity resulting in a range of presentations from Classic BWS to milder features. The previously reported tumor risk based on Classic BWS cohorts is 8–10% and routine tumor screening has been recommended. This work investigated the tumor risk and correlation with phenotype within a cohort of patients from Classic BWS to BWSp using a mixed-methods approach to explore phenotype and epigenotype profiles associated with tumor development through statistical analyses with post-hoc retrospective case series review. We demonstrated that tumor risk across BWSp differs from Classic BWS and that certain phenotypic features are associated with specific epigenetic causes; nephromegaly and/or hyperinsulinism appear associated with cancer in some patients. We also demonstrated that prenatal and perinatal factors that are not currently part of the BWSp classification may factor into tumor risk. Additionally, blood testing results are not necessarily synonymous with tissue testing results. Together, it appears that the current understanding from Classic BWS of (epi)genetics and phenotype correlations with tumors is not represented in the BWSp. Further study is needed in this complex population.
Ridge Jumps and Mantle Exhumation in Back-Arc Basins
Authors: Magni Valentina , Naliboff John , Prada Manel , Gaina Carmen
Published: November 2021

Back-arc basins in continental settings can develop into oceanic basins, when extension lasts long enough to break up the continental lithosphere and allow mantle melting that generates new oceanic crust. Often, the basement of these basins is not only composed of oceanic crust, but also of exhumed mantle, fragments of continental crust, intrusive magmatic bodies, and a complex mid-ocean ridge system characterised by distinct relocations of the spreading centre. To better understand the dynamics that lead to these characteristic structures in back-arc basins, we performed 2D numerical models of continental extension with asymmetric and time-dependent boundary conditions that simulate episodic trench retreat. We find that, in all models, episodic extension leads to rift and/or ridge jumps. In our parameter space, the length of the jump ranges between 1 and 65 km and the timing necessary to produce a new spreading ridge varies between 0.4 and 7 Myr. With the shortest duration of the first extensional phase, we observe a strong asymmetry in the margins of the basin, with the margin further from trench being characterised by outcropping lithospheric mantle and a long section of thinned continental crust. In other cases, ridge jump creates two consecutive oceanic basins, leaving a continental fragment and exhumed mantle in between the two basins. Finally, when the first extensional phase is long enough to form a well-developed oceanic basin (>35 km long), we observe a very short intra-oceanic ridge jump. Our models are able to reproduce many of the structures observed in back-arc basins today, showing that the transient nature of trench retreat that leads to episodes of fast and slow extension is the cause of ridge jumps, mantle exhumation, and continental fragments formation.
Agreement between 3D Motion Analysis and Tele-Assessment Using a Video Conferencing Application for Telerehabilitation
Authors: Lee Kyeongjin
Published: November 2021

The global pandemic of the coronavirus disease 2019 (COVID-19) has highlighted the need for remote healthcare services. This study aimed to evaluate the concurrent validity and reliability of tele-assessment using 3D motion analysis and video conferencing applications. The subjects of this study were 14 Pilates instructors and 14 healthy adults, who repeated five exercises of “side spine stretch”, “bridge”, “toe taps”, “quadruped leg raise”, and “cat and cow” five times each. We performed 3D kinematic analysis with 16 infrared cameras while the subject performed each exercise, and the image captured by one webcam was transmitted to the evaluators through a video conferencing application, and eight raters evaluated the mobility, stability, and symmetry of the movement. The result was then compared with the gold standard 3D motion analysis to evaluate the teleassessment system. The concurrent validity of the data obtained using both methods was analyzed. In addition, the inter-rater reliability of the data from the eight raters was evaluated. As a result, mobility showed excellent (ICC > 0.75, ICCs: intraclass correlation coefficients) or good agreement (ICC = 0.6–0.74) with 3D motion analysis and tele-assessment in all motions. The analysis of stability showed high agreement in general, but it was not significant in “cat and cow.” Symmetry showed moderate agreement only in “bridge” and “toe taps”, showing low agreement compared to other components. In addition, the inter-rater reliability of the tele-assessment showed good agreement (ICC = 0.744). Although there were few components with weaker agreements, the results of this study confirmed that it is a valid and reliable method of tele-assessment using video conferencing applications and showed feasibility as an alternative to the existing face-to-face examination.
Work Intensification and Psychological Detachment: The Mediating Role of Job Resources in Health Service Workers
Authors: Sandoval-Reyes Juan , Restrepo-Castro Juan C. , Duque-Oliva Jair
Published: November 2021

Psychological detachment is the central experience of recovery from work-related stress that allows individuals to reduce burnout symptoms. The stressor-detachment model (SDM) contends that job resources moderate the relationship between job stressors and psychological detachment. We designed an instrument to measure job resources from a multidimensional perspective. A sample of n = 394 individuals from the health service industry participated in the study. Data indicate that job resources comprise a four-factor structure underlying a formative model. Consistent with the SDM, a partial least squares structural equation modeling (PLS-SEM) analysis suggests a moderating effect of job resources (e.g., control over working conditions, leaders’ emotional support), between work intensification and psychological detachment. In addition; results indicate that workers who perceive high levels of support from their organization achieved higher levels of detachment compared with those who perceived low levels of support. Theoretical as well as practical implications for stress management practices, occupational health, and well-being are discussed.
Earth Observation Systems and Pasture Modeling: A Bibliometric Trend Analysis
Authors: Nduku Lwandile , Kalumba Ahmed Mukalazi , Munghemezulu Cilence , Mashaba-Munghemezulu Zinhle , Chirima George Johannes , Afuye Gbenga Abayomi , Busayo Emmanuel Tolulope
Published: November 2021

An Earth observation system (EOS) is essential in monitoring and improving our understanding of how natural and managed agricultural landscapes change over time or respond to climate change and overgrazing. Such changes can be quantified using a pasture model (PM), a critical tool for monitoring changes in pastures driven by the growing population demands and climate change-related challenges and thus ensuring a sustainable food production system. This study used the bibliometric method to assess global scientific research trends in EOS and PM studies from 1979 to 2019. This study analyzed 399 published articles from the Scopus indexed database with the search term “Earth observation systems OR pasture model”. The annual growth rate of 19.76% suggests that the global research on EOS and PM has increased over time during the survey period. The average growth per article is n = 74, average total citations (ATC) = 2949 in the USA, is n = 37, ATC = 488, in China and is n = 22, ATC = 544 in Italy). These results show that the field of the study was inconsistent in terms of ATC per article during the study period. Furthermore, these results show three countries (USA, China, and Italy) ranked as the most productive countries by article publications and the Netherlands had the highest average total citations. This may suggest that these countries have strengthened research development on EOS and PM studies. However, developing counties such as Mexico, Thailand, Sri Lanka, and other African countries had a lower number of publications during the study period. Moreover, the results showed that Earth observation is fundamental in understanding PM dynamics to design targeted interventions and ensure food security. In general, the paper highlights various advances in EOS and PM studies and suggests the direction of future studies.
Raising Awareness about Cloud Security in Industry through a Board Game
Authors: Zhao Tiange , Gasiba Tiago , Lechner Ulrike , Pinto-Albuquerque Maria
Published: November 2021

Today, many products and solutions are provided on the cloud; however, the amount and financial losses due to cloud security incidents illustrate the critical need to do more to protect cloud assets adequately. A gap lies in transferring what cloud and security standards recommend and require to industry practitioners working in the front line. It is of paramount importance to raise awareness about cloud security of these industrial practitioners. Under the guidance of design science paradigm, we introduce a serious game to help participants understand the inherent risks, understand the different roles, and encourage proactive defensive thinking in defending cloud assets. In our game, we designed and implemented an automated evaluator as a novel element. We invite the players to build defense plans and attack plans for which the evaluator calculates success likelihoods. The primary target group is industry practitioners, whereas people with limited background knowledge about cloud security can also participate in and benefit from the game. We design the game and organize several trial runs in an industrial setting. Observations of the trial runs and collected feedback indicate that the game ideas and logic are useful and provide help in raising awareness of cloud security in industry. Our preliminary results share insight into the design of the serious game and are discussed in this paper.
Hybrid Metal-Organic Framework-Cellulose Materials Retaining High Porosity: ZIF-8@Cellulose Nanofibrils
Authors: Thunberg Johannes , Zacharias Savannah C. , Hasani Merima , Oyetunji Olayinka. A. , Noa Francoise M. Amombo , Westman Gunnar , Öhrström Lars
Published: November 2021

Metal-organic frameworks have attracted a great deal of attention for future applications in numerous areas, including gas adsorption. However, in order for them to reach their full potential a substrate to provide an anchor may be needed. Ideally, this substrate should be environmentally friendly and renewable. Cellulose nanofibrils show potential in this area. Here we present a hybrid material created from the self-assembly of zeolitic imidazolate framework (ZIF-8) nanocrystals on cellulose nanofibrils (CNF) in aqueous medium. The CNF/ZIF-8 was freeze dried and formed free standing materials suitable for gas adsorption. A BET area of 1014 m2 g−1 was achieved for the CNF/ZIF-8 hybrid materials ZIF-8@cellulose which is comparable with reported values for free standing ZIF-8 materials, 1600 m2 g−1, considering the dilution with cellulose, and a considerable enhancement compared to CNF on its own, 32 m2 g−1.
A Review of Alternative Controls for House Flies
Authors: Hinkle Nancy C. , Hogsette Jerome A.
Published: November 2021

House flies are the most prevalent synanthropic pest worldwide. Although they seldom reproduce in homes, they invade buildings, cause annoyance, and carry pathogens. Urban pest management personnel are limited in their ability to locate and manage larval habitats, so most house fly management in urban settings focuses on adult fly suppression. Sanitation is probably the most critical component, eliminating odors that attract flies. Source reduction applies where larval habitats can be identified and eliminated. Exclusion involves keeping flies out of structures. Despite all efforts, flies will manage to enter the human environment, so exclusion includes air curtains, fans, screened windows, and doors. Ultraviolet light traps attract and immobilize, while window traps entice flies into devices that entrap them. Sticky tubes and ribbons rely on flies’ inclination to land on vertical lines to entangle them in glue. Even low-tech fly swatters can play significant roles in eliminating individual flies. Timed-release aerosol pyrethrin dispensers can be effective against flies confined in enclosed spaces. Toxic baits have limited use in urban settings. Chemical suppression remains a critical component of fly IPM, essential in situations requiring immediate fly elimination.
Do Hydrothermal Shrimp Smell Vents?
Authors: Ravaux Juliette , Machon Julia , Shillito Bruce , Barthélémy Dominique , Amand Louis , Cabral Mélanie , Delcour Elise , Zbinden Magali
Published: November 2021

Deep-sea species endemic to hydrothermal vents face the critical challenge of detecting active sites in a vast environment devoid of sunlight. This certainly requires specific sensory abilities, among which olfaction could be a relevant sensory modality, since chemical compounds in hydrothermal fluids or food odors could potentially serve as orientation cues. The temperature of the vent fluid might also be used for locating vent sites. The objective of this study is to observe the following key behaviors of olfaction in hydrothermal shrimp, which could provide an insight into their olfactory capacities: (1) grooming behavior; (2) attraction to environmental cues (food odors and fluid markers). We designed experiments at both deep-sea and atmospheric pressure to assess the behavior of the vent shrimp Rimicaris exoculata and Mirocaris fortunata, as well as of the coastal species Palaemon elegans and Palaemon serratus for comparison. Here, we show that hydrothermal shrimp groom their sensory appendages similarly to other crustaceans, but this does not clean the dense bacterial biofilm that covers the olfactory structures. These shrimp have previously been shown to possess functional sensory structures, and to detect the environmental olfactory signals tested, but we do not observe significant attraction behavior here. Only temperature, as a signature of vent fluids, clearly attracts vent shrimp and thus is confirmed to be a relevant signal for orientation in their environment.
Interspecific Hybridization and Complete Mitochondrial Genome Analysis of Two Ghost Moth Species
Authors: Wu Hua , Cao Li , He Meiyu , Han Richou , De Clercq Patrick
Published: November 2021

The Chinese cordyceps, a parasitic Ophiocordyceps sinensis fungus–Thitarodes/Hepialus larva complex, is a valuable biological resource endemic to the Tibetan Plateau. Protection of the Plateau environment and huge market demand make it necessary to culture this complex in an artificial system. A method for the large-scale artificial rearing of the Thitarodes/Hepialus insect host has been established. However, the deterioration of the insect rearing population and low mummification of the infected larvae by the fungus constrain effective commercial cultivation. Hybridization of Thitarodes/Hepialus populations may be needed to overcome this problem. The species T. shambalaensis (GG♂ × GG♀) and an undescribed Thitarodes species (SD♂ × SD♀) were inbred or hybridized to evaluate the biological parameters, larval sensitivity to the fungal infection and mitochondrial genomes of the resulting populations. The two parental Thitarodes species exhibited significant differences in adult fresh weights and body lengths but not in pupal emergence rates. Hybridization of T. shambalaensis and Thitarodes sp. allowed producing a new generation. The SD♂ × GG♀ population showed a higher population trend index than the SD♂ × SD♀ population, implying increased population growth compared with the male parent. The sensitivity of the inbred larval populations to four fungal isolates of O. sinensis also differed. This provides possibilities to create Thitarodes/Hepialus populations with increased growth potential for the improved artificial production of the insect hosts. The mitochondrial genomes of GG♂ × GG♀, SD♂ × SD♀ and SD♂ × GG♀ were 15,612 bp, 15,389 bp and 15,496 bp in length, with an A + T content of 80.92%, 82.35% and 80.87%, respectively. The A + T-rich region contains 787 bp with two 114 bp repetitive sequences, 554 bp without repetitive sequences and 673 bp without repetitive sequences in GG♂ × GG♀, SD♂ × SD♀ and SD♂ × GG♀, respectively. The hybrid population (SD♂ × GG♀) was located in the same clade with GG♂ × GG♀, based on the phylogenetic tree constructed by 13 PCGs, implying the maternal inheritance of mitochondrial DNA.
Heart Team for Optimal Management of Patients with Severe Aortic Stenosis—Long-Term Outcomes and Quality of Life from Tertiary Cardiovascular Care Center
Authors: Jonik Szymon , Marchel Michał , Pędzich-Placha Ewa , Huczek Zenon , Kochman Janusz , Ścisło Piotr , Czub Paweł , Wilimski Radosław , Hendzel Piotr , Opolski Grzegorz , Grabowski Marcin , Mazurek Tomasz
Published: November 2021

Background: This retrospective study was proposed to investigate outcomes of patients with severe aortic stenosis (AS) after implementation of various treatment strategies following dedicated Heart Team (HT) decisions. Methods: Primary and secondary endpoints and quality of life during a median follow-up of 866 days of patients with severe AS qualified after HT discussion to: optimal medical treatment (OMT) alone, OMT and transcather aortic valve replacement (TAVR) or OMT and surgical aortic valve replacement (SAVR) were evaluated. As the primary endpoint composite of all-cause mortality, non-fatal disabling strokes and non-fatal rehospitalizations for AS were considered, while other clinical outcomes were determined as secondary endpoints. Results: From 2016 to 2019, 176 HT meetings were held, and a total of 482 participants with severe AS and completely implemented HT decisions (OMT, TAVR and SAVR for 79, 318 and 85, respectively) were included in the final analysis. SAVR and TAVR were found to be superior to OMT for primary and all secondary endpoints (p < 0.05). Comparing interventional strategies only, TAVR was associated with reduced risk of acute kidney injury, new onset of atrial fibrillation and major bleeding, while the superiority of SAVR for major vascular complications and need for permanent pacemaker implantation was observed (p < 0.05). The quality of life assessed at the end of follow-up was significantly better for patients who underwent TAVR or SAVR than in OMT-group (p < 0.05). Conclusions: We demonstrated that after careful implementation of HT decisions interventional strategies compared to OMT only provide superior outcomes and quality of life for patients with AS.
Effect of INTELLiVENT-ASV versus Conventional Ventilation on Ventilation Intensity in Patients with COVID-19 ARDS—An Observational Study
Authors: Buiteman-Kruizinga Laura A. , Mkadmi Hassan E. , Serpa Neto Ary , Kruizinga Matthijs D. , Botta Michela , Schultz Marcus J. , Paulus Frederique , van der Heiden Pim L.J.
Published: November 2021

Driving pressure (ΔP) and mechanical power (MP) are associated with outcomes in critically ill patients, irrespective of the presence of Acute Respiratory Distress Syndrome (ARDS). INTELLiVENT-ASV, a fully automated ventilatory mode, controls the settings that affect ΔP and MP. This study compared the intensity of ventilation (ΔP and MP) with INTELLiVENT-ASV versus conventional ventilation in a cohort of COVID-19 ARDS patients in two intensive care units in the Netherlands. The coprimary endpoints were ΔP and MP before and after converting from conventional ventilation to INTELLiVENT-ASV. Compared to conventional ventilation, INTELLiVENT-ASV delivered ventilation with a lower ΔP and less MP. With conventional ventilation, ΔP was 13 cmH2O, and MP was 21.5 and 24.8 J/min, whereas with INTELLiVENT-ASV, ΔP was 11 and 10 cmH2O (mean difference –2 cm H2O (95 %CI –2.5 to –1.2 cm H2O), p < 0.001) and MP was 18.8 and 17.5 J/min (mean difference –7.3 J/Min (95% CI –8.8 to –5.8 J/min), p < 0.001). Conversion from conventional ventilation to INTELLiVENT-ASV resulted in a lower intensity of ventilation. These findings may favor the use of INTELLiVENT-ASV in COVID-19 ARDS patients, but future studies remain needed to see if the reduction in the intensity of ventilation translates into clinical benefits.
Antibody-Mediated Rejection and Recurrent Primary Disease: Two Main Obstacles in Abdominal Kidney, Liver, and Pancreas Transplants
Authors: Nakamura Tsukasa , Shirouzu Takayuki
Published: November 2021

The advances in acute phase care have firmly established the practice of organ transplantation in the last several decades. Then, the next issues that loom large in the field of transplantation include antibody-mediated rejection (ABMR) and recurrent primary disease. Acute ABMR is a daunting hurdle in the performance of organ transplantation. The recent progress in desensitization and preoperative monitoring of donor-specific antibodies enables us to increase positive outcomes. However, chronic active ABMR is one of the most significant problems we currently face. On the other hand, recurrent primary disease is problematic for many recipients. Notably, some recipients, unfortunately, lost their vital organs due to this recurrence. Although some progress has been achieved in these two areas, many other factors remain largely obscure. In this review, these two topics will be discussed in light of recent discoveries.
Inaccurate Risk Assessment by the ACS NSQIP Risk Calculator in Aortic Surgery
Authors: Hers Tessa M. , Van Schaik Jan , Keekstra Niels , Putter Hein , Hamming Jaap F. , Van Der Vorst Joost R.
Published: November 2021

Objectives: The aim of this retrospective study was to assess the predictive performance of the American College of Surgeons (ACS) risk calculator for aortic aneurysm repair for the patient population of a Dutch tertiary referral hospital. Methods: This retrospective study included all patients who underwent elective endovascular or open aortic aneurysm repair at our institution between the years 2013 and 2019. Preoperative patient demographics and postoperative complication data were collected, and individual risk assessments were generated using five different current procedural terminology (CPT) codes. Receiver operating characteristic (ROC) curves, calibration plots, Brier scores, and Index of Prediction Accuracy (IPA) values were generated to evaluate the predictive performance of the ACS risk calculator in terms of discrimination and calibration. Results: Two hundred thirty-four patients who underwent elective endovascular or open aortic aneurysm repair were identified. Only five out of thirteen risk predictions were found to be sufficiently discriminative. Furthermore, the ACS risk calculator showed a structurally insufficient calibration. Most Brier scores were close to 0; however, comparison to a null model though IPA-scores showed the predictions generated by the ACS risk calculator to be inaccurate. Overall, the ACS risk calculator showed a consistent underestimation of the risk of complications. Conclusions: The ACS risk calculator proved to be inaccurate within the framework of endovascular and open aortic aneurysm repair in our medical center. To minimize the effects of patient selection and cultural differences, multicenter collaboration is necessary to assess the performance of the ACS risk calculator in aortic surgery.
Amnesia after Midazolam and Ketamine Sedation in Children: A Secondary Analysis of a Randomized Controlled Trial
Authors: Viana Karolline A. , Moterane Mônica M. , Green Steven M. , Mason Keira P. , Costa Luciane R.
Published: November 2021

The incidence of peri-procedural amnesia following procedural sedation in children is unclear and difficult to determine. This study aimed to apply quantitative and qualitative approaches to better understand amnesia following dental sedation of children. After Institutional Review Board Approval, children scheduled for sedation for dental procedures with oral midazolam (OM), oral midazolam and ketamine (OMK), or intranasal midazolam and ketamine (IMK) were recruited for examination of peri-procedural amnesia. Amnesia during the dental session was assessed using a three-stage method, using identification of pictures and an animal toy. On the day following the sedation, primary caregivers answered two questions about their children’s memory. One week later, the children received a semi-structured interview. Behavior and level of sedation during the dental session were recorded. Quantitative data were analyzed using descriptive statistics and comparison tests. Qualitative data were analyzed using content analysis. Triangulation was used. Thirty-five children (age: 36 to 76 months) participated in the quantitative analysis. Most children showed amnesia for the dental procedure (82.9%, n = 29/35) and remembered receiving the sedation (82.1%, n = 23/28 for oral administration; 59.3%, n = 16/27 for intranasal administration). The occurrence of amnesia for the dental procedure was slightly higher in the oral midazolam group compared with the other groups (44.8%, n = 13/29 for OM, 13.8%, n = 4/29 for OMK, and 41.4%, n = 12/29 for IMK). Twenty-eight children participated in the qualitative approach. The major theme identified was that some children could remember their procedures in detail. We conclude that peri-procedural amnesia of the dental procedure was common following sedation.
Evaluation of the Outcome of Local Surgery for Stomal Prolapse
Authors: Kosuge Makoto , Ohkuma Masahisa , Koyama Muneyuki , Kobayashi Yasunobu , Nakano Takafumi , Takano Yasuhiro , Shimoyama Yuya , Takada Naoki , Kumamoto Tomotaka , Imaizumi Yuta , Sugano Hiroshi , Eto Seiichiro , Takeda Yasuhiro , Yatabe Saori , Eto Ken
Published: November 2021

We reviewed the results of local surgical treatment of stoma prolapse, a long-term complication of stoma construction. Fifteen patients treated for stomal prolapse between 2009 and 2020 at the authors’ and affiliated hospitals were included in this study. The treatment comprised local laparotomic stomal reconstruction (LLSR) in nine patients and stapling repair (SR) in six. We compared and evaluated the clinical and surgical information and postoperative complications. Operation time was significantly shorter in the SR group than in the LLSR group: 20 and 53 min, respectively (p = 0.036). The duration of postoperative hospitalization was shorter in the SR group than in the LLSR group: 5.5 and 8 days, respectively; the difference was not significant (p = 0.088). No short-term complications were found in either group. Regarding long-term, postoperative complications, parastomal hernias developed after 2.5 years in one patient in the LLSR group and after 6 months in one patient in the SR group; both patients had histories of parastomal hernia surgery and had relatively high body mass indices. Local surgery for stomal prolapse was minimally invasive and performed safely. In patients with a history of surgery for parastomal hernia, attention must be paid to the potential of parastomal hernia developing as a postoperative complication.
Starting A New Robotic Surgery Program for Mitral Valve Repair. Lessons Learned from The First Nine Months
Authors: Piperata Antonio , Busuttil Olivier , d’Ostrevy Nicolas , Jansens Jean-Luc , Taymoor Saud , Cuko Besart , Modine Thomas , Pernot Mathieu , Labrousse Louis
Published: November 2021

(1) Background: Although transcatheter technology is rapidly growing and represents a promising strategy, the surgical approach remains the best way to repair a degenerative mitral valve regurgitation. In this context, robotic surgery is technologically the most advanced method of minimally invasive mitral valve repair. The aim of this study is to present the preliminary results of the initial single-center experience with a new robotic mitral valve repair program. (2) Methods: We retrospectively reviewed the records of patients who underwent robotic mitral valve repair at our Institution between January and September 2021. (3) Results: A total of 29 patients underwent mitral valve repair with annuloplasty and chordal implantation to treat degenerative mitral regurgitation. The procedure’s success was achieved in 97% of patients. The 30-day cardiac-related mortality was 0%. The median CPB and cross-clamp times were 189 and 111 min, respectively, with a progressive reduction from the beginning of the robotic program. (4) Conclusions: Considering all the limitations related to the small sample, the presented results of robotic mitral valve repair appear to be encouraging and acceptable. A careful patient selection, a dedicated team, and a robust experience in surgical mitral valve repair are the fundamentals to start a new robotic mitral surgery program.
A Case Study on Remote Instrumentation of Vibration and Temperature in Bearing Housings
Authors: Cardona Mariana , Cifuentes Michael , Hernandez Byron , Prado William
Published: November 2021

Data collection is one of the most relevant topics of modern automation and industry. It is usually a costly and time-consuming task, especially in continuous processes. Our case study takes place in a sugar cane mill. The required continuous operation of a belt conveyor for bagasse transportation makes it a critical system in the overall production process. Therefore, a predictive maintenance tool is highly applicable here. We identified bearing housings as critical points for data collection intended for prognostics of the conveyor. However, given the number of points, the cost of a commercial solution becomes unfeasible by our company. This paper reports the development of low-cost devices for measurements and wireless transmission of vibration and temperature data from bearing housings. We assessed several sensor options and made decisions based on a cost-suitability commitment, which led to the design of the electronic devices. The devices were tested for correct operation, reliability (99%), and relative measurement errors under 1.2%. From the tests, we conclude that our proposal is appropriate for our case study’s industrial needs and budget restrictions.
Evaluating Temperature Control in Friction Stir Welding for Industrial Applications
Authors: Wright Arnold , Munro Troy R. , Hovanski Yuri
Published: November 2021

Reports in the literature indicate that temperature control in Friction Stir Welding (FSW) enables better weld properties and easier weld process development. However, although methods of temperature control have existed for almost two decades, industry adoption remains limited. This work examines single-loop Proportional-Integral-Derivative (PID) control on spindle speed as a comparatively simple and cost-effective method of adding temperature control to existing FSW machines. Implementation of PID-based temperature control compared to uncontrolled FSW in AA6111 at linear weld speeds of 1–2 m per minute showed improved mechanical properties and greater consistency in properties along the length of the weld under temperature control. Additionally, results indicate that a minimum spindle rpm may exist, above which tensile specimens do not fracture within the weld centerline, regardless of temperature. This work demonstrates that a straightforward, PID-based implementation of temperature control at high weld rates can produce high quality welds.
Association between Genetic Variants and Cisplatin-Induced Nephrotoxicity: A Genome-Wide Approach and Validation Study
Authors: Zazuli Zulfan , de Jong Corine , Xu Wei , Vijverberg Susanne J. H. , Masereeuw Rosalinde , Patel Devalben , Mirshams Maryam , Khan Khaleeq , Cheng Dangxiao , Ordonez-Perez Bayardo , Huang Shaohui , Spreafico Anna , Hansen Aaron R. , Goldstein David P. , de Almeida John R. , Bratman Scott V. , Hope Andrew , Knox Jennifer J. , Wong Rebecca K. S. , Darling Gail E. , Kitchlu Abhijat , van Haarlem Simone W. A. , van der Meer Femke , van Lindert Anne S. R. , ten Heuvel Alexandra , Brouwer Jan , Ross Colin J. D. , Carleton Bruce C. , Egberts Toine C. G. , Herder Gerarda J. M. , Deneer Vera H. M. , Maitland-van der Zee Anke H. , Liu Geoffrey
Published: November 2021

This study aims to evaluate genetic risk factors for cisplatin-induced nephrotoxicity by investigating not previously studied genetic risk variants and further examining previously reported genetic associations. A genome-wide study (GWAS) was conducted in genetically estimated Europeans in a discovery cohort of cisplatin-treated adults from Toronto, Canada, followed by a candidate gene approach in a validation cohort from the Netherlands. In addition, previously reported genetic associations were further examined in both the discovery and validation cohorts. The outcome, nephrotoxicity, was assessed in two ways: (i) decreased estimated glomerular filtration rate (eGFR), calculated using the Chronic Kidney Disease Epidemiology Collaboration formula (CKD-EPI) and (ii) increased serum creatinine according to the Common Terminology Criteria for Adverse Events v4.03 for acute kidney injury (AKI-CTCAE). Four different Illumina arrays were used for genotyping. Standard quality control was applied for pre- and post-genotype imputation data. In the discovery cohort (n = 608), five single-nucleotide polymorphisms (SNPs) reached genome-wide significance. The A allele in rs4388268 (minor allele frequency = 0.23), an intronic variant of the BACH2 gene, was consistently associated with increased risk of cisplatin-induced nephrotoxicity in both definitions, meeting genome-wide significance (β = −8.4, 95% CI −11.4–−5.4, p = 3.9 × 10−8) for decreased eGFR and reaching suggestive association (OR = 3.9, 95% CI 2.3–6.7, p = 7.4 × 10−7) by AKI-CTCAE. In the validation cohort of 149 patients, this variant was identified with the same direction of effect (eGFR: β = −1.5, 95% CI −5.3–2.4, AKI-CTCAE: OR = 1.7, 95% CI 0.8–3.5). Findings of our previously published candidate gene study could not be confirmed after correction for multiple testing. Genetic predisposition of BACH2 (rs4388268) might be important in the development of cisplatin-induced nephrotoxicity, indicating opportunities for mechanistic understanding, tailored therapy and preventive strategies.
Automated Assessment of the Substantia Nigra Pars Compacta in Parkinson’s Disease: A Diffusion Tensor Imaging Study
Authors: Bergsland Niels , Pelizzari Laura , Laganá Maria Marcella , Di Tella Sonia , Rossetto Federica , Nemni Raffaello , Clerici Mario , Baglio Francesca
Published: November 2021

The substantia nigra (SN) pars compacta (SNpc) and pars reticulata (SNpr) are differentially affected in Parkinson’s disease (PD). Separating the SNpc and SNpr is challenging with standard magnetic resonance imaging (MRI). Diffusion tensor imaging (DTI) allows for the characterization of SN microstructure in a non-invasive manner. In this study, 29 PD patients and 28 healthy controls (HCs) were imaged with 1.5T MRI for DTI. Images were nonlinearly registered to standard space and SNpc and SNpr DTI parameters were measured. ANCOVA and receiver operator characteristic (ROC) analyses were performed. Clinical associations were assessed with Spearman correlations. Multiple corrections were controlled for false discovery rate. PD patients presented with significantly increased SNpc axial diffusivity (AD) (1.207 ± 0.068 versus 1.156 ± 0.045, p = 0.024), with ROC analysis yielding an under the curve of 0.736. Trends with Unified Parkinson’s Disease Rating Scale (UPDRS) III scores were identified for SNpc MD (rs = 0.449), AD (rs = 0.388), and radial diffusivity (rs = 0.391) (all p < 0.1). A trend between baseline SNpr MD and H&Y change (rs = 0.563, p = 0.081) over 2.9 years of follow-up was identified (n = 14). In conclusion, SN microstructure shows robust, clinically meaningful associations in PD.
Financial Literacy as a Driver of Financial Inclusion in Kenya and Tanzania
Authors: Fanta Ashenafi , Mutsonziwa Kingstone
Published: November 2021

Efforts are being exerted in many developing countries to promote financial inclusion by increasing individuals’ access to financial products and services. However, literature suggests that increasing the supply of financial products and services per se may not help in expanding financial inclusion unless concerted efforts are exerted in enhancing financial literacy. This is because financially literate individuals are more likely to appreciate the value of financial services and hence take up financial products. This paper reports the link between financial literacy and inclusion using data from a demand side financial inclusion survey conducted in Kenya and Tanzania in 2016 covering a total of 6029 individuals. Results from our instrumental variable regression analysis confirmed that financial literacy is a strong driver of financial inclusion. This implies that efforts to promote financial inclusion need to be accompanied with financial literacy campaigns in both countries.
Developing a Climate Change Vulnerability Index for Coastal City Sustainability, Mitigation, and Adaptation: A Case Study of Kuala Terengganu, Malaysia
Authors: Bagheri Milad , Zaiton Ibrahim Zelina , Akhir Mohd Fadzil , Talaat Wan Izatul Asma Wan , Oryani Bahareh , Rezania Shahabaldin , Wolf Isabelle D. , Pour Amin Beiranvand
Published: November 2021

Coastal hazards are an urgent issue of global concern considering the increasing population pressure in coastal regions, retreating coastlines, and rising seawater levels. Here we demonstrate the process of assessing the vulnerability of a coastal urban environment using the case of Kuala Terengganu, a coastal town in Malaysia, and evaluating the potential social, environmental, and economic impacts. Uncertainties in the human dimensions of global change deeply affect the assessment and responses to environmental, climatic, and non-climate impacts on coastal city population growth and communities. We address these uncertainties by combining a Delphi-Analytical Hierarchy Process (Delphi-AHP) model and Geographic Information System (GIS)tools to determine mitigation and adaptation probabilities as part of a Coastal City Vulnerability Assessment. We conclude by presenting calculations of the short- and long-term suitability for land use and recommending hazard mitigation measures to equip city planners and decision-makers in evaluating hazards and potential impacts on coastal city areas.
Analysis of Spatial–Temporal Characteristics of Industrial Land Supply Scale in Relation to Industrial Structure in China
Authors: Dai Peichao , Sheng Ruxu , Miao Zhongzhen , Chen Zanxu , Zhou Yuan
Published: November 2021

Taking China’s industrial land transfer data as the data source, this study quantitatively analyzes the transfer structure and spatial distribution of China’s industrial land from 2010 to 2019. By constructing the information entropy and the equilibrium degree model of industrial land-use structure, this study evaluates the transfer characteristics of industrial land of different functional types in various provinces of China, analyzes the scale advantages of various types of transferred industrial land by using the land transfer scale advantage index, and summarizes the spatial distribution characteristics of different types of industrial land transfer in China through the spatial center of gravity analysis and cold/hot spot regional distribution mapping. The following results were obtained. (1) There are significant differences in the transfer scale of industrial land among provinces in China. The transfer scale of Eastern and Central China is large, whereas that of Western China is small. (2) From the perspective of land-use structure, the transfer scale of industrial land in the central and western regions is more balanced than that in the east. (3) From the gravity center distribution of the standard deviation ellipse, the land transfer direction of the energy industry, and the mining industry, and other types of industries is more significant than that of the culture and sports hygiene industries, modern manufacturing industry, and high-tech industry. (4) From the analysis of cold and hot spots, the mining industry, the energy industry, and other types of industries in the western region with rich mineral resources are the hot spots of industrial land transfer, and the southeast coast is the cold spot; the eastern coastal area is a hot area for land transfer of modern manufacturing, the high-tech industry, and the culture and sports hygiene industries. The results reveal the regional differences and spatial distribution characteristics of industrial transfer in China and provide a reference for authorities to formulate industrial planning and industrial land collection, storage, and transfer plans.
Water Dams of the Krakow Fortress: Potential of a Vanishing Heritage
Authors: Korbel Wojciech , Suchoń Filip , Łapuszek Marta
Published: November 2021

Cultural heritage conservation is a constant process of preserving the valuable historical legacy and transferring it to future generations. The ability to adapt the matter under conservation to changing needs and environmental conditions is an essential element of this process. In this context, climate change and its consequences are a growing challenge, requiring innovative and often simultaneous efforts. This study was conducted in response to the discovery of previously unknown documents on nineteenth-century impoundment structures of the Krakow Fortress’s defensive system. At present, the facilities are almost entirely ruined, yet the need to restore and preserve the memory of their culturally valuable legacy merits investigation. The conditions and requirements of the management of Krakow’s changing hydrological environment became a vital component of this study. The uncovered archival documents were subjected to historical-interpretative analysis. Virtual modeling contributed to identifying the original scope of the dams’ impact. Analysis of the city’s spatial planning documents pointed to their contemporary potential. The entirety of the material collected aided in determining the framework in which protective measures targeting this dying heritage are currently possible. This study features a proposal for a new form of recreating the structures under investigation by assigning them a range of possible simultaneous uses. Thus, the presented research proposal is a form of concern for preserving this historical legacy and an attempt at rising to contemporary challenges posed by an intensively changing environment.
Research on the Evaluation Index System of the Soil Remediation Effect Based on Blockchain
Authors: Wang Menghua , Liang Xuedong , Li Zhi
Published: November 2021

Soil remediation technology has achieved good results at present, but evaluation research on the soil remediation effect is relatively lacking. In the field of soil remediation effect evaluation, there are problems such as unscientific and imperfect indices and the inability to guarantee the authenticity of data. Based on the research results of domestic and foreign scholars and the soil remediation standards of some developed countries, a set of recommended indices for soil remediation evaluation has been formed through the analysis and screening of a large number of documents and the results of expert consultation. However, there are phenomena such as lack of data authenticity, information asymmetry, and low supervision efficiency. Based on the technical characteristics of the blockchain and the current soil remediation effect evaluation requirements, combined with the research results of domestic and foreign scholars and the soil remediation standards of some developed countries, the core technology and corresponding application scenarios were analysed for functional requirements in this paper. The introduction of blockchain technology will improve the authenticity of data and form a decentralized, trustworthy, and traceable supervision model. Finally, an evaluation index system of the soil remediation effect based on blockchain was constructed from the following five aspects: collection of soil remediation indices, the addition of a new blockchain-based soil remediation effect evaluation and supervision model, the determination of index weights, a list of soil remediation effect evaluation indices, and providing feedback and suggestions. Through the application of blockchain technology and the innovative addition of the “regional policy” evaluation index, changes and innovations were made in all aspects of the soil remediation effect evaluation process.
Spatiotemporal Pattern and Driving Factors of Urban Sprawl in China
Authors: Zhang Xin , Pan Jinghu
Published: November 2021

Urban sprawl is a complex phenomenon related to abnormal urbanization, and it has become a key issue of global concern. This study aimed to measure urban sprawl in China and explore its spatiotemporal patterns and driving factors. Based on 343 Chinese cities at the prefecture level and above, remote sensing-derived data from 2000 to 2017 were used to calculate the urban sprawl index (USI). The evolutionary trend and spatiotemporal pattern of urban sprawl in China were then analyzed using trend analysis and exploratory spatiotemporal data analysis, and Geodetector was applied to investigate the factors driving the changes. The results show the following. ① Moderate or high urban sprawl development occurred in China from 2000 to 2017. In terms of spatial distribution, the USI was high in northwest China and low in southeast China. ② The local spatial stability of the USI gradually decreased from southeast to northwest and northeast. USI had strong spatial dependence. No significant spatiotemporal transitions in urban sprawl were observed, and the spatial pattern was stable with strong spatial cohesion. ③ The gross regional product (GRP) of the tertiary industry, the total GRP, and investment in real estate development have been the most important factors affecting sprawl in cities at the prefecture level and above in China.