bluuebunny/crossref_metadata_2025 huggingface dataset:
Repressing iron overload ameliorates central post-stroke pain via the Hdac2-Kv1.2 axis in a rat model of hemorrhagic stroke
Authors: Fang He , Li Mengjie , Yang Jingchen , Ma Shunping , Zhang Li , Yang Hongqi , Tang Qiongyan , Cao Jing , Yang Weimin
Published: April 2024

JOURNAL/nrgr/04.03/01300535-202412000-00027/figure1/v/2024-05-29T122840Z/r/image-tiff

Thalamic hemorrhage can lead to the development of central post-stroke pain. Changes in histone acetylation levels, which are regulated by histone deacetylases, affect the excitability of neurons surrounding the hemorrhagic area. However, the regulatory mechanism of histone deacetylases in central post-stroke pain remains unclear. Here, we show that iron overload leads to an increase in histone deacetylase 2 expression in damaged ventral posterolateral nucleus neurons. Inhibiting this increase restored histone H3 acetylation in the Kcna2 promoter region of the voltage-dependent potassium (Kv) channel subunit gene in a rat model of central post-stroke pain, thereby increasing Kcna2 expression and relieving central pain. However, in the absence of nerve injury, increasing histone deacetylase 2 expression decreased Kcna2 expression, decreased Kv current, increased the excitability of neurons in the ventral posterolateral nucleus area, and led to neuropathic pain symptoms. Moreover, treatment with the iron chelator deferiprone effectively reduced iron overload in the ventral posterolateral nucleus after intracerebral hemorrhage, reversed histone deacetylase 2 upregulation and Kv1.2 downregulation, and alleviated mechanical hypersensitivity in central post-stroke pain rats. These results suggest that histone deacetylase 2 upregulation and Kv1.2 downregulation, mediated by iron overload, are important factors in central post-stroke pain pathogenesis and could serve as new targets for central post-stroke pain treatment.
Fluconazole resistance in candida isolates from vaginal discharge in women attending an Apex Regional Sexually Transmitted Infections Center
Authors: Panda Pragyan Swagatika , Muralidhar Sumathi , Lachyan Abhishek , Khan Nilofar , Rajan Santhosh , Kumar Shilpee , Khunger Niti
Published: April 2024

Background:

Globally, vulvovaginal candidiasis (VVC) is a common infection in women. Candida
albicans is the most common agent. There is an increasing prevalence of non-albicans Candida (NAC) species, mostly in vulnerable populations, responding poorly to fluconazole, the drug of choice for VVC. It leads to treatment failure, especially in clinical isolates with intrinsic fluconazole resistance; hence, appropriate identification and antifungal susceptibility testing (AFST) are of paramount importance to ensure better clinical outcomes.

Aims and Objective:

The aim of this study was to identify different Candida species isolated from women with VVC and to evaluate their antifungal drug susceptibility pattern. A retrospective observational study including a total of 286 isolates of Candida spp. isolated from 729 women with vaginal discharge attending the Outpatient Department of an Apex Regional Sexually Transmitted Infections Center in North India over 1 year (June 2022–May 2023) was performed. Identification and AFST were performed as per standard microbiological procedures. Statistical analysis was carried out using the SPSS version 22.0 (SPSS Inc., Chicago, IL, USA). Data were presented as percentages and proportions.

Results:

Candida isolates were detected in 39.23% of women. The median age was 26–35 years. C. albicans was the most common isolate (60.8%), followed by Candida
glabrata (31.8%), Candida tropicalis (4.19%), Candida
parapsilosis (2.09%), Candida
krusei (0.699%), and Candida
kefyr (0.34%). Fluconazole resistance was seen in 29% of the isolates and susceptible dose-dependent in 32.15%.

Conclusion:

Increasing isolation of NAC species (39.2%) causing VVC and responding poorly to fluconazole (29% resistant strains) is a major concern. Timely and appropriate AFST will help improve the clinical outcome and quality of life.
Study of sociodemographic factors associated with anemia during pregnancy at a university hospital in India
Authors: Fareed Kulsum , Gupta Uma , Khatoon Ruby
Published: April 2024

Background:

Between 25% and 50% of pregnant women and almost half of nonpregnant women suffer from anemia, a common health problem, especially in developing and poor countries. Anemia is one of the most common diseases in women during pregnancy.

Aim:

Of this study was to investigate the prevalence of anemia in pregnant women, its morphological characterization, and associated sociodemographic characteristics.

Materials and Methods:

This was a cross-sectional study conducted on 290 pregnant women from Lucknow, Uttar Pradesh, India. The demographic data of the participants (age, place of residence, religion, education, employment status, type of housing, socioeconomic status, and source of drinking water) were collected. A general and physical examination was performed. They were assessed for anemia and its severity.

Statistical Analysis:

The Chi-square test, independent-samples t-test, and analysis of variance were used for statistical analysis.

Results:

A total of 290 pregnant women aged 18–38 years were included in the study. A total of 161 individuals (55.5%) were diagnosed with anemia. The prevalence and severity of anemia largely correlated with maternal age (<20 years or > 30 years), lower body mass index, higher education level, employment status, medication use, and lack of iron supplementation. Employment status, Kachcha residence, lower intake of nonvegetarian diet, lower intake of green leafy vegetables, nonuse of oral contraceptives in the past 3 months, and iron supplementation were found to be significantly associated with anemia severity.

Conclusions:

A high prevalence of anemia during pregnancy was found in this community. Higher prevalence and severity of anemia were closely related to increasing maternal age, low socioeconomic position, and lack of iron supplementation.
Utility of the Xpert Xpress CoV-2/Flu/RSV Plus Kit: A Glance at RSV Infection in Adults and Coinfection Rate
Authors: Alkharsah Khaled R.
Published: April 2024

Background:

Viral infection is responsible for the majority of respiratory tract infections (RTI). This retrospective study evaluates the advantages of using the multiplex Xpert Xpress CoV-2/Flu/RSV plus kit in laboratory diagnosis of RTI caused by the most related viruses.

Materials and Methods:

Data were obtained from medical records between November 2021 and May 2023 for any sample tested using either the Xpert Xpress Flu/RSV kit, Xpert Xpress Flu kit, Xpert Xpress SARS-CoV-2 kit, and Xpert Xpress CoV-2/Flu/RSV plus kit.

Results:

Influenza virus A was detected in 8.5% (55/649) of the samples using the Flu PCR kit and in 4.9% (123/2538) using CoV-2/Flu/RSV plus kit, while influenza virus B detection rates were 3.7% (24/649) using the Flu PCR kit and 1.7% (43/2538) using the CoV-2/Flu/RSV plus kit. However, the detection rates using the two kits were comparable when evaluated for the same time period of the year. SARS-CoV-2 infections were detected in 16.9% (1545/9153) and 10.5% (266/2538) of the cases using the SARS-CoV-2 kit and CoV-2/Flu/RSV plus kits, respectively. Respiratory syncytial virus (RSV) was identified in 17.7% (66/372) of children using Flu/RSV kit; this number dropped significantly when age-targeted testing of RSV was performed due to involvements of adults. With the CoV-2/Flu/RSV plus kit, about 34% (35/103) of RSV infections detected were in patients aged >20 years; these cases would have previously been overlooked because adults are not routinely tested for RSV using the Flu/RSV kit. All coinfection cases (n = 16) were only detected with the CoV-2/Flu/RSV plus kit.

Conclusion:

The use of Xpert Xpress CoV-2/Flu/RSV plus kit not only results in shorter turnaround times through accurate detection of all four viruses, but also provides information on RSV infection in adults and coinfection rates.
Delayed Sequence Intubation in Children, Why Not?
Authors: Rebollar Ramón Eizaga , Hierro Paula Lozano , Fernández Ana Mercedes Martínez-Almendros
Published: April 2024

Tracheal intubation in pediatric patients is a clinical scenario that can quickly become an emergency. Complication rates can potentially reach up to 60% in rapid sequence intubation. An alternate to this is delayed sequence intubation, which may reduce potential complications—mostly hypoxemia—and can be especially useful in non-cooperative children. This technique consists of the prior airway and oxygenation optimization. This is done through sedation using agents that preserve ventilatory function and protective reflexes and continuous oxygen therapy—prior and after the anesthetic induction—using nasal prongs. The objective of this narrative review is to provide a broader perspective on delayed sequence intubation by defining the concept and indications; reviewing its safety, effectiveness, and complications; and describing the anesthetic agents and oxygen therapy techniques used in this procedure.
Intelligent manufacturing: bridging the gap between the Internet of Things and machinery to achieve optimized operations
Authors: Yuanfang Wei  , Li Song
Published: April 2024

The access gateway layer in the IoT interior design bridging the gap between several destinations. The capabilities include message routing, message identification, and a service. IoT intelligence can help machinery industries optimize their operations with perspectives on factory processes, energy use, and help efficiency. Automation can bring in improved operations, lower destruction, and greater manufacture. IoT barriers are exactly developed for bridging the gap between field devices and focused revenues and industrial applications, maximizing intelligent system performance and receiving and processing real-time operational control data that the network edge. The creation of powerful, flexible, and adjustable Human Machine Interfaces (HMI) can enable associates with information and tailored solutions to increase productivity while remaining safe. An innovative strategy for data-enabled engineering advances based on the Internet of Manufacturing Things (IoMT) is essential for effectively utilizing physical mechanisms. The proposed method HMI-IoMT has been gap analysis to other business processes turns into a reporting process that can be utilized for improvement. Implementing a gap analysis in production or manufacturing can bring the existing level of manpower allocation closer to an ideal level due to balancing and integrating the resources. Societal growth and connection are both aided in the built environment. Manufacturing operations are made much more productive with the help of automation and advanced machinery. Increasing the output of products and services is possible as a result of this efficiency, which allows for the fulfillment of an expanding population's necessities.
Investigation of Quantitative Assessment Techniques for Supply-Regulation Capability in Multi-Scenario New-Type Power Systems
Authors: Liu Miao , Wang Zesen , Xin Guangming , Li Qi , Kong Shuaihao
Published: April 2024

This paper offers an in-depth investigation into various quantitative assessment methods used to quantify the supply regulation capacity in new types of power systems under different conditions. As new forms of energy, including renewables, are increasingly becoming the predominant sources of power systems, the traditional systems are undergoing transformative modifications to efficiently address the issue of power generation and consumption fluctuations. In this regard, this paper proposes an original framework that combines advanced statistical methods and machine learning. The primary purpose of the framework is to identify the level of resilience and flexible adaptability of new power systems. The paper presents the results of the simulations and real-world applications of the proposed measurement methods in enhancing power supply reliability and efficiency in all conditions. The implications based on the results will be beneficial to policymakers and other specialists who are making decisions involving designing and optimizing modern power systems. Furthermore, the paper aims to contribute to the existing discussion by providing further insights into the effectiveness of the proposed methods of measurement.
Closed geodesics and Frøyshov invariants of hyperbolic three-manifolds
Authors: Lin Francesco , Lipnowski Michael
Published: April 2024

Frøyshov invariants are numerical invariants of rational homology three-spheres derived from gradings in monopole Floer homology. In the past few years, they have been employed to solve a wide range of problems in 3- and 4-dimensional topology. In this paper, we look at connections with hyperbolic geometry for the class of minimal

L

-spaces. In particular, we study relations between Frøyshov invariants and closed geodesics using ideas from analytic number theory. We discuss two main applications of our approach. First, we derive explicit upper bounds for the Frøyshov invariants of minimal hyperbolic

L

-spaces purely in terms of volume and injectivity radius. Second, we describe an algorithm to compute Frøyshov invariants of minimal

L

-spaces in terms of data arising from hyperbolic geometry. As a concrete example of our method, we compute the Frøyshov invariants for all spin

^{c}

structures on the Seifert–Weber dodecahedral space. Along the way, we also prove several results about the eta invariants of the odd signature and Dirac operators on hyperbolic three-manifolds which might be of independent interest.
Zeros and roots of unity in character tables
Authors: Miller Alexander Rossi
Published: April 2024

For any finite group

G

, Thompson proved that, for each

\chi \in \operatorname{Irr}(G)

,

\chi(g)

is either zero or a root of unity for more than a third of the elements

g\in G

, and Gallagher proved that, for each larger than average class

g^{G}

,

\chi(g)

is either zero or a root of unity for more than a third of the irreducible characters

\chi \in \operatorname{Irr}(G)

. We show that in many cases “more than a third” can be replaced by “more than half”.
Gaussian elimination for flexible systems of linear inclusions
Authors: Van Tran Nam , van den Berg Imme
Published: April 2024

Flexible systems are linear systems of inclusions in which the elements of the coefficient matrix are external numbers in the sense of nonstandard analysis. External numbers represent real numbers with small, individual error terms. Using Gaussian elimination, a flexible system can be put into a row-echelon form with increasing error terms on the right-hand side. Then parameters are assigned to the error terms and the resulting system is solved by common methods of linear algebra. The solution set may have indeterminacy not only in terms of linear spaces, but also of modules. We determine maximal robustness for flexible systems.
Evaluation of a Design Support Tool Incorporating Sensory Performance Model of Ride Comfort for Conceptual Design of Controlled Suspensions
Authors: Kikuchi Hironobu , Inaba Kazuaki
Published: April 2024

The objective of this study is to introduce and assess a computational tool designed to facilitate product development via sensory scores, which serve as a quantifiable representation of human sensory experiences. In the context of designing ride comfort performance, the specialized terminology—either technical or sensory—often served as a barrier to comprehension among the diverse set of specialists constituting the multidisciplinary team. In a previous study by the authors introduced a tool that incorporated a model of sensory performance, utilizing sensory scores as universally comprehensible metrics. However, the tool had yet to be appraised by a genuine cross-functional team. In this study, the tool underwent evaluation through a user-testing process involving twenty-five cross-functional team members engaged in the conceptual design phase at an automotive manufacturing company. Five different suspension systems were examined, including a wheel rotational speed-driven damper system developed by the authors. To evaluate the best performance of each suspension systems, sensory scores served as the objective function. Design parameters were obtained by an improved particle swarm optimization 3

PSO) algorithm. The assessment procedure included participants experiencing simulated vibrations through a ride simulator. This was followed by the participants' subjective evaluations of the vibrations and structured interviews aimed at ascertaining the tool's advantages. The results revealed that 92% of participants responded the tool would be beneficial for their work. Moreover, a new sensory performance model was then constructed, incorporating principal components derived from combined vibration data and weights determined by the collected sensory scores for four distinct feature groups.
An Improved AEB Control System Based on Risk Factors with Consideration of Vehicle Stability
Authors: Guo Shaozhong , Guo Jun , Zhang Yunqing , Wu Jinglai
Published: April 2024

Intelligent vehicle-to-everything connectivity is an important development trend in the automotive industry. Among various active safety systems, Autonomous Emergency Braking (AEB) has garnered widespread attention due to its outstanding performance in reducing traffic accidents. AEB effectively avoids or mitigates vehicle collisions through automatic braking, making it a crucial technology in autonomous driving. However, the majority of current AEB safety models exhibit limitations in braking modes and fail to fully consider the overall vehicle stability during braking. To address these issues, this paper proposes an improved AEB control system based on a risk factor (AERF). The upper-level controller introduces the risk factor (RF) and proposes a multi-stage warning/braking control strategy based on preceding vehicle dynamic characteristics, while also calculating the desired acceleration. Furthermore, a lower-level PID-based controller is designed to track the desired acceleration and compute the corresponding brake master cylinder pressure and throttle opening using an established inverse longitudinal dynamics model. Furthermore, to address vehicle stability during braking, an Anti-lock Braking System (ABS) controller is integrated with the proposed AERF. The effectiveness of the AERF is validated through software co-simulation and hardware-in-the-loop testing (HIL). The results demonstrate that the AERF can maintain a safe braking distance within 2 meters under Euro NCAP standard conditions, with excellent tracking performance of the actual braking deceleration and an error rate below 5%, ensuring a high level of system safety.
Advanced Biomass Conversion: Sustainable e-Methanol Production with Enhanced CO 2 Utilization
Authors: Fernandes Renston Jake , Nguyen Ducduy , Shakeel Mohammad Raghib , Turner James W.G.
Published: April 2024

Amid escalating concerns over climate change and emissions, this study presents a novel approach to develop sustainable fuels, leveraging advanced process modeling that uses waste CO2 streams from the biological ethanol fermentation process to produce e-methanol. Using Aspen Plus software, this research focuses on the conversion of biomass such as sugar cane and sugar beet to reduce reliance on fossil fuels and fortify energy resilience in a sustainable manner. In the first phase, bagasse, a byproduct of sugar production that is rich in carbon is used as a precursor for gasification and as a fuel to generate high-pressure steam. Oxygen obtained from electrolysis of water using renewable energy is used to preheat the biological exothermic fermentation phase. The CO2 captured during the fermentation phase is mixed with hydrogen obtained from the electrolysis process to synthesize e-methanol. Lignin, a byproduct of second-generation bioethanol, and surplus bagasse are identified and converted into ethanol and e-methanol, respectively, optimizing the use of CO2 from fermentation and O2 from electrolysis. Lastly, gasification of the carbon-rich bagasse serves to further enhance methanol production, culminating in the generation of enriched e-methanol. This results in enhanced bioenergy, bio-carbon recovery and consequently reduced fossil CO2 emissions, offering a holistic CO2 and biomass management solution. This research introduces a groundbreaking approach to sustainable fuel production, significantly advancing over traditional methods by implementing a closed carbon cycle that fully utilizes every carbon atom from biomass feedstock. This contrasts sharply with conventional practices where carbon dioxide is often released as a byproduct, aggravating greenhouse gas emissions. A key innovation is the waste-to-value conversion, where byproducts like bagasse and lignin are transformed into valuable fuel sources, adding a new dimension of resource optimization absent in traditional fuel production. The environmental impact is profound, with a potential substantial reduction in greenhouse gas emissions, particularly in the transport sector, positioning this method as a sustainable alternative aligned with global environmental goals. Economically, it promises enhanced viability through improved resource utilization and efficiency, presenting a holistic solution that addresses both energy needs and environmental concerns, a significant leap forward from the limitations of traditional fossil fuel-based methods.
A Review of Production Multi-Motor Electric Vehicles and Energy Management and Model Predictive Control Techniques
Authors: Allca-Pekarovic Alexander , Kollmeyer Phillip , Middleton Mairi , Emadi Ali
Published: April 2024

This paper presents the characteristics of more than 260 trim levels for over 50 production electric vehicle (EV) models on the market since 2014. Data analysis shows a clear trend of all-wheel-drive (AWD) powertrains being increasingly offered on the market from original equipment manufacturers (OEMs). The latest data from the U.S. Environmental Protection Agency (EPA) shows that AWD EVs have seen a nearly 4 times increase in production from 21 models in 2020 to 79 models in 2023. Meanwhile single axle front-wheel-drive (FWD) and rear-wheel-drive (RWD) drivetrains have seen small to moderate increases over the same period, going from 9 to 11 models and from 5 to 12 models, respectively. Further looking into AWD architectures demonstrates dual electric machine (EM) powertrains using different EM types on each axle remain a small portion of the dual-motor AWD category. However, these architectures have been shown to have energy savings of 1 % to 5 % over that of identical dual-motor permanent magnet (PM) machine or dual-motor induction machine (IM) architectures. Further work shows dual motor architectures with an IM powering the front axle and a PM machine powering the rear axle under mathematical optimization-based controls to be less energy consuming than the same architecture subjected to a rule-based energy management strategy (EMS). This leads to a review of electrified vehicle EMSs, with the two main methods of rule-based and optimization-based controls being presented. The pros and cons of each control method are stated with optimization-based methods showing the most benefit. The optimal control method of model predictive control (MPC) is then presented by covering its’ background, structure, variations, and mechanics. Finally, the use of MPC as a viable EMS for multi-motor EVs is reviewed with motor thermal regulation as part of the control objective.
Inherent Diverse Redundant Safety Mechanisms for AI-Based Software Elements in Automotive Applications
Authors: Pitale Mandar Manohar , Abbaspour Alireza , Upadhyay Devesh
Published: April 2024

This paper explores the role and challenges of Artificial Intelligence (AI) algorithms, specifically AI-based software elements, in autonomous driving systems. These AI systems are fundamental in executing real-time critical functions in complex and high-dimensional environments. They handle vital tasks like multi-modal perception, cognition, and decision-making tasks such as motion planning, lane keeping, and emergency braking. A primary concern relates to the ability (and necessity) of AI models to generalize beyond their initial training data. This generalization issue becomes evident in real-time scenarios, where models frequently encounter inputs not represented in their training or validation data. In such cases, AI systems must still function effectively despite facing distributional or domain shifts. This paper investigates the risk associated with overconfident AI models in safety-critical applications like autonomous driving. To mitigate these risks, methods for training AI models that help maintain performance without overconfidence are proposed. This involves implementing certainty reporting architectures and ensuring diverse training data. While various distribution-based methods exist to provide safety mechanisms for AI models, there is a noted lack of systematic assessment of these methods, especially in the context of safety-critical automotive applications. Many methods in the literature do not adapt well to the quick response times required in safety-critical edge applications. This paper reviews these methods, discusses their suitability for safety-critical applications, and highlights their strengths and limitations. The paper also proposes potential improvements to enhance the safety and reliability of AI algorithms in autonomous vehicles in the context of rapid and accurate decision-making processes.
Between God and Man: The Great Adventure in Common (Isidore of Seville’s De ortu et obitu Patrum)
Authors: Krynicka Tatiana
Published: April 2024

In his De ortu et obitu Patrum, Isidore of Seville elaborates a collection of stories that engage the reader in living the experiences of the characters presented and encourage him to identify with them and imitate them. Following the ways of the biblical heroes, the Sevillian comes to know the One who has called all of them into existence as beings created for coexistence and pro-existence, i.e. to live with and for others. Isidore does not write a history of sinners, but of saints, who become friends of God by building a community with other humans and filling the world with his praise. According to him, both his heroes and his readers are relational beings, open to God and to other creatures, in need of them to achieve their fullness.
Nota sobre la presencia femenina en el tratado isidoriano De ortu et obitu Patrum
Authors: Cabrera Montero Juan Antonio
Published: April 2024

El tratado exegético ort. et obit. de Isidoro incluye la presentación detallada de tres mujeres que representan, cada una según su historia, las virtudes femeninas más destacadas en la Escritura. Isidoro presenta sus perfiles basándose en el texto bíblico y en la tradición teológica que ya en su época si había ido configurando y asentando. Una atención especial merece el capítulo dedicado a María que no solamente sintetiza la reflexión mariológica anterior, sino que constituye una de las bases para su desarrollo posterior.
liturgia en san Isidoro de Sevilla: compositor, legislador y teólogo
Authors: Rueda Gómez Luis
Published: April 2024

El artículo trata sobre la labor litúrgica del insigne Arzobispo de Sevilla san Isidoro. Se contextualiza su trabajo en la metodología usada y en el periodo histórico-evolutivo de la Liturgia Hispánica. Se exponen los textos que se le han atribuido tanto por criterios externos como por criterios internos. Se analizan los cánones de los Concilios en que participó: particularmente el Concilio II de Sevilla y el Concilio IV de Toledo. También se estudian las disposiciones litúrgicas de las Reglas para los Monjes. Por último, se analiza los temas litúrgicos tratados en sus obras Los Oficios Eclesiásticos y las Etimologías.
Yves Congar, su aportación al Concilio Vaticano II
Authors: Bosch Juan
Published: April 2024

Con motivo de la celebración del 30 aniversario de la clausura del Concilio Vaticano II -el acontecimiento religioso más importante del siglo XX- el autor de este artículo aborda la contribución de Yves Congar a la asamblea, que puede ilustrarse con los escritos del dominico francés de 1959 a 1965
Las conferencias dogmático-morales y litúrgicas en el pontificado del Cardenal Spínola y Maestre (1896-1906)
Authors: Martín Riego Manuel
Published: April 2024

Este trabajo es una aproximación a la labor desarrollado por el arzobispo sevillano con vistas a la formación permanente del clero. Se analiza la figura de Spínola, la organización de las cátedras eclesiásticas, la junta directiva diocesana, la organización de las instituciones de estudio en el arciprestazgo y los temas tratados en las mismas. Se estudian los modelos de estas conferencias en cuatro instituciones: San Bartolomé y San Román en Sevilla, Écija y El Puerto de Santa María. Finalmente, se ofrecen algunas conclusiones
METODOLOGIAS ATIVAS
Authors: Meroto Monique Bolonha das Neves , Sobrinho Benedito Braz , Guimarães Christiane Diniz , Costa Edivan Jorge , Castilho Luciane Pereira de
Published: April 2024

As metodologias ativas representam um redirecionamento essencial no ensino, colocando o aluno como protagonista do processo educacional. Focadas na participação ativa e na aplicação prática do conhecimento, estratégias como Aprendizagem Baseada em Projetos, Sala de Aula Invertida e Aprendizagem Colaborativa buscam promover um ambiente dinâmico e inclusivo. Ao desafiar o modelo tradicional de aprendizagem passiva, essas abordagens fomentam habilidades socioemocionais e cognitivas, preparando os alunos para desafios contemporâneos. Contudo, a implementação dessas metodologias enfrenta desafios como resistência à mudança, falta de recursos tecnológicos e necessidade de capacitação docente. Para superar tais obstáculos, são essenciais estratégias de formação continuada, acesso a tecnologias adequadas e apoio institucional. Com a aplicação prática dessas estratégias na escola, observou-se um aumento na participação dos alunos, melhorias no desempenho escolar e uma maior integração de conceitos teóricos com a prática, especialmente notáveis nas disciplinas eletivas e no apoio a alunos da Educação Especial.
INTEGRANDO TECNOLOGIAS E METODOLOGIAS INOVADORAS NO ENSINO-APRENDIZAGEM
Authors: Santos Silvana Maria Aparecida Viana , Silva Freilan Pereira da , Vieira Priscila Caser de Assis , Machado Renato , Silva Tatiana Petúlia Araújo da
Published: April 2024

Este estudo aborda a crescente integração de tecnologias e metodologias inovadoras no processo de ensino-aprendizagem, visando identificar estratégias eficazes que promovam uma aprendizagem interativa e engajadora. O problema investigado centra-se na maneira como as ferramentas tecnológicas podem ser alinhadas com as necessidades pedagógicas e curriculares para maximizar o potencial de aprendizado dos alunos. O objetivo geral é explorar práticas pedagógicas que integrem tecnologias digitais no currículo, avaliando seu impacto na experiência educacional dos estudantes. Através da análise de literatura relevante e estudos de caso, como o desenvolvimento de jogos digitais em contextos educativos, o trabalho evidencia a importância de uma abordagem planejada que considere a relação entre tecnologia, pedagogia e currículo. As considerações finais destacam a necessidade de formação continuada dos educadores, adaptação dos currículos e uma reflexão contínua sobre as práticas pedagógicas para aproveitar as oportunidades oferecidas pelas tecnologias digitais. Conclui-se que a integração eficaz de tecnologias e metodologias inovadoras requer uma abordagem holística que favoreça a aprendizagem significativa e prepare os alunos para os desafios de uma sociedade digitalizada.
The Effect of Service Quality and Toll Price Rates on Toll Road User Satisfaction (Case Study on Kelapa Gading – Pulo Gebang Toll Road)
Authors: Rahaviana Khairunnisa Pertiwi , Widyaningsih Nunung
Published: April 2024

Toll road construction is one of the main supporting aspects in the process of accelerating Indonesia's national development. However, along with population growth and regional development, road infrastructure is increasingly filled with various modes of transportation which ultimately causes buildup and congestion. The construction of toll roads in Jakarta is one alternative to break down congestion in the city. The construction of the Kelapa Gading - Pulo Gebang Toll Road is expected to be able to increase road capacity so as to facilitate transportation between the two regions.  However, the varied toll rates cause different perceptions in its users. Toll tariff determination is generally oriented towards financial analysis which results in not being commensurate with the ability (Ability To Pay) and desire (Willingness To Pay) as well as the determination of the ideal tariff of the community as toll road service users. This research uses a descriptive method with a quantitative approach. Data collection using questionnaires and documentation. The research population of the entire Jakarta city community in 2022 is 10,679,951 people, the number of samples calculated using the Slovin method resulted in 100 respondents selected through certain criteria. Data analysis uses validity tests, reliability tests and descriptive analysis. The results showed that the level of driver satisfaction with the quality of service of the Kelapa Gading - Pulo Gebang Toll Road was in the "Satisfied" category as evidenced by the Customer Satisfaction Index (CSI) value of 78.62% which was in the range of 61% to 80% so that it was in the "Satisfied" category. Then, the quality of service and tariff policy have a positive effect on the satisfaction of users of the Kelapa Gading - Pulo Gebang toll road, which is indicated by the F value calculated > F table (48.060>3.09) and the significance of < 0.05 (0.00<0.05) means significant / influential. The respondent's Ability To Pay (ATP) on the highest Kelapa Gading - Pulo Gebang toll road tariff was Rp. 166,766.24, namely for respondents with the job category as a Housewife / Father and the lowest ATP was Rp. 125,620.99, namely for respondents with the job category as Students or Students. The  average Ability To Pay (ATP) value of all respondents was Rp. 147,582.02. While  the respondent's Willingnes To Pay (WTP) value on the highest respondent's Kelapa Gading - Pulo Gebang toll road tariff was Rp. 21,750, namely for respondents with the job category as Students or Students and the lowest WTP was Rp. 20,523, namely for respondents with the job category as Civil Servants (PNS) or TNI / Polri. The  average Willingnes To Pay (WTP) value of all respondents was Rp. 20,970.
Toward "Better" Meat? Aligning Meat Sourcing Strategies with Corporate Climate and Sustainability Goals
Authors: Waite Richard , Zionts Jessica , Cho Clara
Published: April 2024

This report helps consumer-facing food companies with climate and other sustainability goals plan to source not only “less meat” but also “better meat.” Because “better meat” has many meanings, this report reviews evidence on the links between meat production, climate change, and other aspects of sustainability, looking across production practices and systems. It recommends six steps to help food companies meet multiple sustainability goals, from environmental impact measurement and sourcing strategy design to supplier engagement.
Bioplásticos - Una alternativa para reducir la contaminación: RSL
Authors: Picho Asto Gabriela , Gutierrez Barreto Deyssi July , Alvarado León Daniel Edgar , Larrea Cerna Crhistian Omar
Published: April 2024

En el presente estudio se aborda una revisión sistemática de literatura (RSL) sobre el desarrollo actual de bioplásticos como alternativa sostenible debido a su degradabilidad. La metodología consistió en una búsqueda exhaustiva en la base de datos Scopus utilizando palabras clave sobre bioplásticos, biodegradables, almidón, entre otros. Se aplicaron criterios de inclusión y exclusión, obteniendo finalmente 30 artículos relevantes publicados en los últimos 5 años (2018 - 2023). Los resultados muestran que los principales tipos de bioplásticos en desarrollo son los plásticos biodegradables de recursos fósiles, compostables y de base biológica. El tiempo de degradabilidad varía entre 6 meses a 10 años dependiendo de los materiales, aunque pocos estudios especifican este dato. Los aditivos más utilizados en la producción de bioplásticos son plastificantes, espesantes y emulsionantes. Los materiales y productos biodegradables que más se emplean incluyen almidón de maíz, papa, yuca. En cuanto a la importancia del desarrollo de bioplásticos, la mayoría de estudios resaltan su contribución a la reducción de la contaminación ambiental y el manejo de residuos. En conclusión, el desarrollo de bioplásticos a partir de fuentes renovables es una alternativa sostenible y amigable que garantice su correcta degradación.
Efecto del zapallo y la zanahoria en las características nutricionales del yogurt natural
Authors: Logroño Veloz Mayra Alexandra , Betancourt Ortiz Sarita Lucila , Fonseca Jiménez Janet Graciela
Published: April 2024

Introducción: El yogurt, es un producto resultante de la fermentación de la lactosa por acción bacteriana (St. themophilus y L. bulgaricus) con producción de ácido láctico, presenta mayor digestibilidad respecto de la leche en individuos intolerantes, permite la inclusión de productos que aumenten su contenido nutricional y aceptación, convirtiéndose en una alternativa para mejorar los problemas de déficit nutricionales de la población en general. Objetivo: Formular un yogur con la adición de zapallo (Cucúrbita máxima) y zanahoria (Daucus carota) y medir sus características organolépticas, bromatológicas y nutricionales. Metodología: El estudio fue cualitativo y cuantitativo con un diseño experimental factorial 22 proporcionando 4 tratamientos los factores fueron las cantidades de azúcar y la mezcla de zanahoria con zapallo previamente cocida, con la adición constante de 0.7 g (0.01%) de cultivo probiótico cepas de Lactobacillus Bulgaricus y Streptococcus Thermophilus. Resultados: El tratamiento T3 presentó mayor aceptabilidad con una apariencia heterogénea, de color naranja, aroma lácteo, textura semilíquida y sabor semidulce; y mostró diferencias estadísticas significativas con un p ≤ 0.001 en cuanto al aporte de fibra, carbohidratos totales y cenizas. Conclusiones: El yogurt puede ser considerado como un alimento funcional con baja cantidad de calorías, medio en grasa, bajo en azúcar, no contiene sal y se recomienda su consumo por el aporte importante de fibra.
WhatsApp una herramienta de comunicación en salud para estudiantes universitarios
Authors: Guacho Tixi Mercy Esthela , Andrade Cuadrado Carlos Eduardo , Llanga Vargas Edgar Francisco
Published: April 2024

Introducción: En la actualidad el WhatsApp se ha convertido en el medio de comunicación idóneo y ágil más utilizado por los estudiantes para compartir o difundir recursos de información o académicos, quienes han adoptado la comunicación en tiempo real o sincrónica como una forma usual de establecer contacto. Objetivo: Identificar las preferencias de uso del WhatsApp en los estudiantes de la carrera de medicina de la Escuela Superior Politécnica de Chimborazo. Métodos: Estudio descriptivo de cohorte transversal, para determinar el uso y utilidades del WhatsApp. Se trabajó con 309 estudiantes entre 19 – 26 años de edad, seleccionados a través de un muestreo aleatorio simple. Resultados: El 36.25% de los estudiantes que participaron corresponde a hombres y el 63.75 % a mujeres. El celular es el dispositivo más utilizado por los estudiantes para conectarse al internet y corresponde al 87.38%, el 66.99% utilizan WhatsApp como una herramienta de interacción y comunicación virtual. El 51.8% utiliza el  WhatsApp para compartir temas académicos y el 22.7% temas de salud en general. Conclusiones: WhatsApp se ha convertido en la herramienta más utilizada para la interacción y comunicación virtual a nivel mundial, los estudiantes de la carrera de medicina comparten mediante esta aplicación información en el ámbito académico o de salud en general, ya que les permite establecer una conversación sencilla y natural.
Successful Treatment of Cerebral Tuberculoma in Acquired Immune Deficiency Syndrome Patient a Case Report
Authors:   Pulmonology and Critical Care Medicine fellowship FK-KMK UGM / Dr. Sardjito Central General Hospital, Saksana Rachmad Aji , Trisnawati Ika ,   Division Pulmonologi Departement Internal Medicine FK-KMK UGM / Dr. Sardjito Central General Hospital, Budiono Eko ,   Division Pulmonologi Departement Internal Medicine FK-KMK UGM / Dr. Sardjito Central General Hospital
Published: April 2024

Introduction: Tuberculosis (TB) remains a leading problem in developing and endemic countries. Cerebral tuberculosis is a rare but dangerous complication of tuberculosis infection in the central nervous system. The immunosuppressive condition in human immunodeficiency virus infection is a risk factor for severe tuberculosis. Case Report: An Indonesian man, 32 years old, married, came with complaints of headaches, dizziness, delirium, nausea and vomiting since 1 month before the examination. He had a history of TB treatment 1 year before the examination. The results of the neurological examination were within normal limits, the HIV test was reactive and there was a decrease in CD4. Head MRI examination with contrast showed multiple solid nodules in the thalamus with the largest size 2.3×2.7 cm, indicating cerebral tuberculoma. Chest x-ray was normal, GeneXpert MTB sputum was not detected. Next, primary treatment is given with anti-tuberculosis drugs, Highly Active Antiretroviral Therapy (HAART), co-trimoxazole, and dexamethasone. There was clinical, laboratory and radiological improvement after 12 months of treatment. Viral load is undetectable, CD4 is elevated. A head CT scan did not show tuberculoma. He became healthy and was able to return to work Discussion: Cerebral tuberculoma is a condition characterized by the presence of intracranial tuberculoma. The clinical manifestations are non-specific, such as headaches or seizures. This is caused by space occupying lesions and increase intracranial pressure. In this case, the diagnosis of cerebral tuberculoma was made through head MRI with contrast. TB therapy and co-trimoxazole are given as soon as the diagnosis is made, while antiretrovirals are given 2 weeks after he has tolerated the TB medication. The minimum duration of therapy for cerebral tuberculosis is 12 months. He require lifelong antiretroviral medication. Conclusion: Tuberculoma should be considered as differential diagnosis of space-occupying lesions in patients HIV/AIDS. Early diagnosis, adequate therapy, patient adherence and family support can cure severe tuberculosis.
The etiology and treatment of refractory Hypothyroidism - management issues: A cross sectional observational study
Authors: Dr Babul Reddy Hanmayyagari
Published: April 2024

Introduction: Primary hypothyroidism is considered to be refractory to treatment when there is clinical or biochemical evidence of hypothyroidism (level of TSH above the target range, usually 5.5 mIU/L) even after 6 weeks of treatment with Levothyroxine at a dosage of 1.9 mcg/kg/day. This study intended to find out the common factors responsible for the refractory nature of the hypothyroidism. The study also highlights how simple correction measures would improve the outcomes. Materials and Methods: This is a prospective, Cross sectional and observational study conducted in the Department of Endocrinology, Sapthagiri Institute of Medical Sciences and Research center. The study population included 25 patients with treatment refractory hypothyroidism. The patients were identified after screening about 900 patients with primary hypothyroidism, between age group of 15-50 years and BMI of 19-25 kg/m2. Levothyroxine absorption test was performed when deemed necessary. Results: In 10 patients (40%) the reason for refractory nature of the hypothyroidism was found to be due to keeping the levothyroxine containers in the kitchen close to flame or above the refrigerator and due to disposing of the silica pack from the container. In 8 (32%) patients the reason was inappropriate timing of Levothyroxine with food and beverages or due to the usage of concomitant medications. 6 (24%) patients used generic Levothyroxine, which could be less effective. Remaining 1 patient (4%) were subjected to Levothyroxine absorption test, which suggested that malabsorption is the etiological factor. Conclusions: The most common reason for the refractory nature of the hypothyroidism was found to be due to improper storing conditions of the medication. The other reasons included switching over to the generic brands of levothyroxine, and not maintaining the adequate time gap between consumption of Levothyroxine and interfering medications like antacids. Malabsorption was found to be uncommon reason for refractory hypothyroidism.
Acute Appendicitis in Elderly Population a Study of the Various Risk Factors for Severity of Appendicitis
Authors: Dr Samuel Kevin  , Dr Rai Rakesh A  , Dr Reshmina Chandni Clara Dsouza
Published: April 2024

Appendicitis in the elderly continues to be a challenging surgical problem. Being a potential life endangering pathology. It accounts for 5% of all acute abdominal condition in people aged more than 65 years .Mortality rates being 16 times more when compared to a young adult with appendicitis and complication rates like perforation being as high as to 70% as the disease presents with Vague symptoms and with a more virulent pathologic course that allows rapid progression of the disease which leads to delayed hospitalization, diagnosis, treatment and increased morbidity and mortality. Material and Methods - A 5 year retrospective cross sectional Chart review was done to collect information on patient’s above 60 years of age who had undergone appendicetomy .Demographic data , clinical presentation ,delay in hospital arrival and co morbid condition ,usg and intra operative findings noted and analysed Results:- Out of 111 elderly patients, 71 males and 40 females with a mean age of 69.8 years, 88 had hypertension,62 with diabetes , 19 ckd . 61 proved to have perforated appendicitis, 37 males and 24 females with significant delay in hospital arrival duration of 2-7 days .Perforation rates were increased in patients with multiple comorbities (diabetes, hypertension,ckd) and delay in hospital arrival. Conclusion: A high index of suspicion is needed in elderly patients with acute abdomen to prevent misdiagnosis. Delay in presentation to the hospital and multiple comorbidities are the main risk factors associated with higher rates of appendicular perforation.
Blood Cultures for the Detection of Bacteremia
Authors: Iddah, M. Ali  , Benard O. Wesonga
Published: April 2024

A blood culture is a test that checks for foreign invaders like bacteria, yeast, and other microorganisms in One’s blood. Having these pathogens in One’s bloodstream can be a sign of a blood infection, a condition known as bacteremia. A positive blood culture means that you have bacteria in One’s blood. In this article, issues related to types of bacteremia, indications, and technique for blood cultures will be reviewed here.
Treating Stroke-Like Episodes with Carbamazepine May Trigger Psychosis
Authors: Finsterer J, MD, PhD
Published: April 2024

The indication for applying CBZ was obviously the SLE. It was propagated to treat all SLEs with anti-seizure drugs (ASDs) irrespective if the patient presents with seizures or shows epileptiform discharges on electroencephalography (EEG). This management of SLEs has been recently challenged. SLEs may not only be driven by seizures, as mentioned in the introduction, as they occur in the absence of clinical or subclinical seizures and in the absence of epileptiform discharges on EEG.