bluuebunny/crossref_metadata_2025 huggingface dataset:
Parental Perceptions of Participation in Special Education Foci on Hispanic and White Children's Ethnicity and Educational Levels
Authors: Krach Kathleen , Ochoa Salvador , Palmer Douglas
Published: March 2023

The authors of this study discuss past research, litigation, and legislation pertaining to the topic of parental involvement in special education. In particular, the study examined parental perceptions of their roles as communicators and decision makers in the special education process in terms of ethnicity and child's educational level. Very few items revealed differences between the perceptions of Hispanic parents when compared to the perceptions of White parents, but as children advance academically, there is less agreement among parents that they were involved as communicators and decision makers. Data from our sample of Hispanic and White parents of children with high-incidence disabilities indicate that parents in Texas perceive that their schools do engage in activities to facilitate parental communication and individualized education program decision making regardless of ethnicity.
Mecanismos de resistencia al trastuzumab
Authors: Korbenfeld Ernesto
Published: March 2023

El trastuzumab es un anticuerpo monoclonal dirigido contra el receptor del factor de crecimiento epidérmico humano (Her2), el cual se encuentra sobreexpresado en aproximadamente el 20% del cáncer de mama invasivo. El trastuzumab es un claro ejemplo de exitoso desarrollo de terapia “blanco específica” en oncología y actualmente se encuentra aprobado para su uso terapéutico en cáncer de mama Her2+ tanto en enfermedad avanzada como con criterio adyuvante. Sin embargo, alrededor del 50% de las pacientes con cáncer de mama Her2+ no se benefician de las terapias basadas en trastuzumab. El entendimiento de los mecanismos de acción y de resistencia al trastuzumab es crucial para el desarrollo de nuevas estrategias de tratamiento. Los mecanismos de resistencia al trastuzumab se pueden agrupar en 4 categorías principales: A. Obstáculos para la unión del trastuzumab al dominio extracelular del Her2. B. Activación de las vías de traducción de señales río abajo del Her2. C. Activación de vías alternativas del Her2. D. Fallas del sistema inmunitario para destruir las células tumorales. Esta revisión resume las evidencias preclínicas y clínicas acerca de los mecanismos de acción y resistencia al trastuzumab y también discute el desarrollo de nuevas drogas antiHer2 y sus posibles implicancias clínicas.
IN MEMORIAM Profesor Doctor Andrés Angulo Ormeño
Authors: Vives Moreno Antonio
Published: March 2023

IN MEMORIAM
Análisis de la determinación de la fuente y la implicancia del establecimiento permanente de los servicios digitales
Authors: Lugo Pérez Rut Eunice
Published: March 2023

a digitalización en la economía impuso el desafío a los gobiernos de adecuar las legislaciones tributarias, ante una economía digital que avanza de manera radical en el mundo. Las incidencias en el mercado de estos nuevos modelos de negocio en forma electrónica hacen que las Administraciones Tributarias tengan como resultado el estudio de nuevos impuestos que afecten en forma directa a las plataformas digitales. Se puede decir, que las economías lati- noamericanas están abordando eficientemente los desafíos fiscales obtenidos por la digitalización de la economía; lo cual contribuirá a la estabilidad en el sistema tributario internacional. Por lo tanto, se pretende que las empresas multinacionales ofrezcan sus actividades digitales en la región y obtengan importantes ingresos en varios países, sin tener una residencia fiscal en los mismos, además de tener y cumplir unas obligaciones tributarias. Paraguay entra en el proceso al ejecutar la fiscalidad internacional a través de la Ley N°. 6380/2019 en la que se establece el tratamiento fiscal aplicable a las rentas provenientes de actividades de prestación de servicios digitales desarrollados por quienes no son residentes y aprovechados en el país. Se parte de la premisa de los elementos que componen el establecimiento permanente según las normas tributarias; se examinan los aspectos generales de los servicios digitales y así establecer las incidencias de la fuente y la implicancia del establecimiento permanente de los servicios mencionados en Para- guay al 2021. Se concluye que la AT paraguaya cuenta con la facultad suficiente para dictar actos necesarios para la aplicación, administración, percepción de los tributos, hasta la fecha ha fijado posición en lo referente a la retención desde la fuente del IVA e INR, faltando mucho para enfrentar todos los aspectos que intervienen en la composición de los servicios digitales.
Estudio comparativo del Régimen Precio de Transferencia en Paraguay
Authors: González Rios Vivian Giselle
Published: March 2023

La implementación del Régimen Tributario de Precios de Transferencias en América Latina y el Caribe se ubica principalmente en la última década del siglo XX. En el año 2021, la CIAT (Centro Interamericano de Administraciones Tributarias) realizó un estudio denominado Base de Datos sobre Normas y Prácticas de precios de transferencia en América Latina y el Caribe, en el que se puede notar la evolución creciente de la incorporación de las normas de PT de Paraguay mediante un estudio comparativo del Régimen de PT con Argentina, Ecuador, Panamá, Venezuela y Colom- bia al 2021. En cuanto, a los criterios utilizados, Paraguay ha tomado los criterios de la OCDE y del propio país, mientras tanto otros utilizaban sus propios criterios tributarios o la combinación de ambos. Por un lado, otro aspecto que resaltar es que países vecinos como Argentina y Venezuela ingresaban a sus normas tributarias el régimen de PT en los años 1998 y 1999 respectivamente y, por otra parte, utilizando solo Criterios de la OCDE Colombia, Ecuador y Panamá lo hacían los años 2004,2005 y 2011; en cambio, Paraguay en el año 2019 introdujo normas de PT mediante la Ley 6380/2019 de Modernización y Simplificación del Sistema Tributario Nacional y puesta en vigencia en el 2020, posicionando así a Paraguay como último en la Base de Datos de la CIAT.
Chat como mecanismo de asistencia al contribuyente en la Administración Tributaria en Paraguay al 2022
Authors: Vergara Arzamendia  Jazmín Soledad
Published: March 2023

Los aportes que el gobierno electrónico a través de las Tecnologías de Información y Comunicación (TIC) provee a la nación, incluye numerosas actividades de formación tanto en línea como presencial, misiones de asesoramiento técnico, documentación y diseminación de mejores prácticas, creación de redes de expertos, entre otros. Paraguay ha logra- do ingresar en la era digital al colocar en funcionamiento la automatización de los procesos de gobierno como parte de las estrategias de bienestar al ciudadano. Actualmente, a pesar de la situación pospandemia, la SET ha automatización los servicios online en la relación con los contribuyentes, a través de su portal electrónico, donde el contribuyente puede declarar impuestos y actualizar su información del RUC, entre otros trámites, sin necesidad de asistir a las oficinas del organismo; el administrado tiene acceso a toda la información necesaria sobre tributos internos, consultas e información, denuncias en línea, publicaciones orientadas a incrementar la cultura tributaria del administrado. El objetivo general es proponer un chat como mecanismo de asistencia al contribuyente en la Administración Tributaria en Paraguay al 2022; esta investigación será basada según el enfoque cualitativo, el cual se desarrolla a través del método de la fenomenología. La autora concluye que el chat es herramienta de mejora para la interacción entre la Administración Tributaria y el Administrado en tiempo real, conforme a los principios de gobierno electrónico. La página Web de la SET sería vanguardista al ser informativa, dinámica e interactiva. Todo esto logrado mediante el desarrollo de la política de Gobierno en Línea, presentando un abanico de información y orientación general a las personas, con el propósito de facilitar el uso del servicio; desarrollando el derecho constitucional que tiene toda persona de recibir información veraz e imparcial.
Peningkatan Literasi Digital Melalui Kegiatan bermain Untuk Siswa SDN Jamaras Cugenang Cianjur
Authors: Widaningsih Themotia Titi , Syafuddin Khairul , Setyopratinjo Listijono
Published: March 2023

Warga yang berada di Kabupaten Cianjur, Jawa Barat saat ini tengah mengalami kondisi yang sulit. Hal ini diakibatkan karena adanya gempa bumi yang terjadi di sana pada 21 November 2022. Bencana ini mengakibatkan proses belajar mengajar menjadi terhenti. Salah satu pembelajaran yang penting untuk dilakukan terkait dengan literasi digital, terutama di daerah yang mengalami bencana. Oleh sebab itu, perlu diadakan kegiatan peningkatan literasi digital untuk siswa SDN Jamaras, Kecamatan Cugenang, Kabupaten Cianjur. Dalam kondisi pasca bencana, tim PKM Usahid melakukan peningkatan literasi digital melalui strategi permainan. Kegiatan ini dilakukan dengan memberikan kemampuan literasi digital kepada 202 siswa SD beserta guru yang mendampinginya. Kegiatan PKM ini dapat memberikan bekal dan pengetahuan kepada para siswa SD terkait budaya digital, etika dalam bermedia sosial, dan Undang Undang Perlindungan data Pribadi secara ringan. Siswa diajak berperan aktif dalam kegiatan bermain dan belajar dan dibekali skill dalam memahami jenis hoaks dan cara melawannya.
ESPIRITUALIDADE NO CANCER
Authors: Paleczna Monika
Published: March 2023

Um diagnóstico de câncer, como acontece com qualquer doença grave, levanta questões difíceis: por que eu? Porque agora? Por que eu deveria sofrer assim? O que vai acontecer comigo depois da morte? Infelizmente, a solução para esses problemas não é imediata nem óbvia. Além do mais, essas questões interferem no mundo ordenado da espiritualidade, muitas vezes questionando os pensamentos existentes nas esferas existencial e religiosa. Um diagnóstico desencadeia questões profundas sobre o significado e o propósito da vida.
The Grammar of Science: How “Good” is Your Instrument?
Authors: Kaewkungwal Jaranit
Published: March 2023

-
PENGEMBANGAN PERANGKAT PEMBELAJARAN MATEMATIKA MODEL PROBLEM POSING UNTUK MENINGKATKAN KEMAMPUAN BERPIKIR KRITIS MATEMATIS SISWA DI SMP NEGERI MANDALA
Authors: Balok Bergita , Ralmugiz Uke , Fatmawati Agustin , Syarief Nur Hasanah
Published: March 2023

The purpose of this study was to determine the development of a valid, practical and effective Problem Posing Modelas a learning tool. This research and development study (R&D) with 4-D have some phases, namely: define, design, develop, and desiminate. The data collection technique used  test (description/essay) and non-test (tool validation and questionnaire). The data were analyzed through validity analysis, practicality analysis, and effectiveness analysis. The instruments used in this study were questionnaires,validation sheets, Lesson Plan, student’s worksheets, and test. The study showed that lesson plan is stated to be very valid with an average score of 90.15 in the k > 80 category andstudent’s worksheets is declared very valid with an average score of 84.58 in the k > 80 category. The students and teachers’ response are stated to be very practical with the average score of 80.55 in the k > 80 category. Besides, the effectiveness is declared effective seen from the students’ learning outcomes with 72% in the 60 ≤ p < 80 category. Thus, it can be concluded that the learning tool developed, Problem Posing Model is declared valid, practical and effective so that it can be used in learning mathematics.
Proximate composition and organoleptic properties of oven-dried Aba knife fish (Gymnarchus Niloticus)
Authors: Paul Tosin , Ekop I.E. , Simonyan K.J.
Published: March 2023

This study investigates the quality composition of Aba knife fish (Gymnarchus Niloticus) predominant in South-eastern Nigeria. The fish sample require proper processing techniques to preserve their organoleptic qualities for a substantial period. The objective of the study was to investigate the influence of oven-drying process on the proximate and organoleptic qualities of Gymnaruchus Niloticus. The studied fresh fish fillets were rinsed in clean water, brined and spread in trays before taken for oven drying. An oven drier (FALC STF-F-52) was used for the oven-drying process. Analyses of proximate compositions (moisture content, crude lipid, crude protein, ash content and crude fiber) were carried out on the fresh and oven dried fish samples. The study showed that oven drying decreases the moisture content to a safe level of 38.13 ± 0.01% dry basis(d.b), and increase the crude protein content (18.23±0.01), fat content (4.34±0.01), ash content (3.40±0.01), carbohydrate content (35.96±0.01) of the investigated fish samples. There were no crude fibre contents (0.00) in the fresh fish samples. Therefore, the oven drying process had no noticeable effect on the fibre content. The oven dried fish samples were rated high in terms of taste, aroma, colour, texture and general acceptability by the panel of assessors. The significance of the obtained results as well as recommendations for further studies were offered.
Research on Improving the Service Management Consciousness of Library Information Work Based on Network Environment
Authors: Li Hairong
Published: March 2023

Under the background of the new era, "Internet plus" is the deep practical result of Internet thinking, which has effectively promoted the development and innovation of library information work. This article analyzes the changes in the service characteristics of library information work and the special significance of information services in the new era, probes into the promotion and application strategies of service awareness of information work, and proposes that libraries should use Internet technology to innovate the service mode of library information work in the network era, which virtually highlights the importance of enhancing the service awareness of library information work. This article starts with the importance of studying the importance of enhancing the service management awareness of library information work, elaborates on innovative service content and methods, and proposes effective application strategies based on actual situations, providing strong theoretical support for researchers.
Morbidity and Mortality Profile of Neonates Admitted in Special Newborn Care Unit in a Tertiary Care Hospital: A Retrospective Study
Authors: Rahman Mahibur , Bezboruah Gayatri , Bhoktiari Monalisa
Published: March 2023

Introduction: Newborn period is the most vulnerable phase of life and deaths during first 28 days of life account for 70% of all infant deaths and 56% of all deaths of under-5 year in children. Children who die within the first 28 days of birth suffer from conditions and diseases associated with lack of quality care at or immediately after birth and in the first few days of life. Aim: To study the morbidity and mortality profile of neonates admitted in Special Newborn Care Unit (SNCU) in a tertiary care hospital. Materials and Methods: This hospital-based retrospective study was carried out in SNCU, Department of Paediatrics, Gauhati Medical College and Hospital (GMCH), Guwahati, Assam, India. The study period was from 1st July 2021 to 30th June 2022. A total of 7439 neonates (both inborn and outborn) from birth to 28 days of life admitted in SNCU during the study period were included in the study. Morbidity and mortality data of admitted neonates were collected from the monthly reporting format and patient records and compiled in MS Excelsheet and analysed using arithmetic mean and also expressed in percentages. Results: During the study period, 7439 neonates were admitted in SNCU, inborn 4854 (65.3%) and outborn 2585 (34.7%). Male and female 4305 (57.9%) vs 3134 (42.1%). Normal birth weight and Low Birth Weight (LBW) babies 4200 (56.5%) vs 3239 (43.5%). Term and Preterm (PT) babies 4424 (59.5%) vs 3015 (40.5%). Neonatal jaundice, birth asphyxia and neonatal sepsis were common morbidities requiring admission. Mortality was 12.1% which was higher in outborn (21.5%) than inborn (7.1%). Birth asphyxia (45.3%) was the commonest cause of mortality followed by Respiratory Distress Syndrome (RDS) with prematurity (20.4%) and neonatal sepsis (15.1%). Birth asphyxia was higher in outborn (47.5%) than inborn (41.9%). Neonatal sepsis was higher in outborn (18.3%) than inborn (9.9%). Highest number of death occured within seven days of birth (70.2%) and among LBW babies (61%). Conclusion: Birth asphyxia, RDS with prematurity and neonatal sepsis are common causes of neonatal mortality. Outcomes of this study can be used for improving the existing healthcare services to reduce neonatal mortality.
Growth, Yield and Nutrient Content of Mungbean as Influenced by Foliar Potassium Application and Irrigation Levels
Authors: Shivashankar K. , Singh Adesh , Singh Ankur
Published: March 2023

A field experiment was conducted in 2018 to study the response of Summer Mungbean (Vigna radiata L. Wilczek) to foliar potassic fertilization under different moisture regimes. The experiment was laid out in split plot design by having 16 treatment combinations with 2 irrigation levels in the main plot and 6 foliar potassium sprays in subplots, which were replicated thrice. Results revealed that the growth parameters of mungbean viz., plant height, plant spread, number of leaves/plant, LAI, dry matter accumulation/plant, and grain yield were significantly higher under 0.6 IW/CPE ratio as compared to 0.4 IW/CPE ratio. Nutrient content (N, P and K) was also found higher under 0.6 IW/CPE ratio than 0.4 IW/CPE ratio. Among potassium treatments, foliar application of 1%K through KNO3/KCl at flowering and pod development stage produced significantly higher values of growth parameters viz., plant height, number of leaves and branches/plant and dry matter accumulation/plant at all the stages of growth except at 25 DAS. Foliar application of 1%K through KNO3/KCl at flowering and pod development stage recorded significantly higher grain and straw yield than rest of the treatments. Nutrient content was found higher under foliar application of 1%K through KNO3/KCl at flowering and pod development stage but did not differ significantly.
Timing of Confirmatory Trials for Drugs Granted Accelerated Approval Based on Surrogate Measures From 2012 to 2021
Authors: Deshmukh Anjali D. , Kesselheim Aaron S. , Rome Benjamin N.
Published: March 2023

This cross-sectional study systematically characterizes the frequency of delayed confirmatory trials relative to deadlines set by the US Food and Drug Administration.
Association of Clinician Practice Ownership With Ability of Primary Care Practices to Improve Quality Without Increasing Burnout
Authors: Rotenstein Lisa S. , Cohen Deborah J. , Marino Miguel , Bates David W. , Edwards Samuel T.
Published: March 2023

Importance

Work environments and practice structural features are associated with both burnout and the ability of practices to enhance quality of care.

Objective

To characterize factors associated with primary care practices successfully improving quality scores without increasing clinician and staff burnout.

Design, Setting, and Participants

This cross-sectional study assessed small- to medium-sized primary care practices that participated in the EvidenceNOW: Advancing Heart Health initiative using surveys that were administered at baseline (September 2015 to April 2017) and after the intervention (January 2017 to October 2018). Data were analyzed from February 2022 to January 2023.

Main Outcomes and Measures

The primary outcome of being a quality and well-being positive deviant practice was defined as a practice with a stable or improved percentage of clinicians and staff reporting burnout over the study period and with practice-level improvement in all 3 cardiovascular quality measures: aspirin prescribing, blood pressure control, and smoking cessation counseling.

Results

Of 727 practices with complete burnout and aspirin prescribing, blood pressure control, and smoking cessation counseling data, 18.3% (n = 133) met the criteria to be considered quality and well-being positive deviant practices. In analyses adjusted for practice location, accountable care organization and demonstration project participation, and practice specialty composition, clinician-owned practices had greater odds of being a positive deviant practice (odds ratio, 2.02; 95% CI, 1.16-3.54) than practices owned by a hospital or health system.

Conclusions and Relevance

In this cross-sectional study, clinician-owned practices were more likely to achieve improvements in cardiovascular quality outcomes without increasing staff member burnout than were practices owned by a hospital or health system. Given increasing health care consolidation, our findings suggest the value of studying cultural features of clinician-owned practices that may be associated with positive quality and experience outcomes.
Effects of a Responsive Parenting Intervention Among Black Families on Infant Sleep
Authors: Lavner Justin A. , Hohman Emily E. , Beach Steven R. H. , Stansfield Brian K. , Savage Jennifer S.
Published: March 2023

Importance

Black individuals in the US experience sleep disparities beginning in infancy and continuing throughout the lifespan, suggesting early interventions are needed to improve sleep.

Objective

To investigate whether a responsive parenting (RP) intervention for Black mothers improves infant sleep and increases responsive sleep parenting practices.

Design, Setting, and Participants

This is a post hoc secondary analysis of the Sleep SAAF (Strong African American Families) study, a randomized clinical trial comparing an RP intervention with a safety control condition over the first 16 weeks post partum. Data were collected between spring 2018 and summer 2021. Families were recruited from the mother-infant nursery at Augusta University Medical Center, Augusta, Georgia, and completed home visits at 1, 3, 8, and 16 weeks post partum. Primiparous Black mother-infant dyads were screened for eligibility using medical records. Results were analyzed on an intention-to-treat model. Data were analyzed from March 2022 to January 2023.

Interventions

The RP intervention curriculum focused on infant sleep, soothing and crying, and feeding. The control group received a safety intervention. Community research associates delivered the interventions during home visits at 3 and 8 weeks post partum.

Main Outcomes and Measures

The primary end point was infant sleep duration at 16 weeks. Mothers reported on bedtime routine and sleep behaviors, infant sleep duration, and nighttime waking and feeding at 8 and 16 weeks post partum using questionnaires.

Results

A total of 212 Black mothers (mean [SD] age, 22.7 [4.5] years) were randomized, including 208 mothers (98.6%) who identified as non-Hispanic and 3 mothers (1.4%) who identified as Hispanic; 108 mothers were randomized to the RP group and 104 mothers were randomized to the control group. At 16 weeks post partum, infants in the RP group had longer reported nighttime sleep duration (mean difference, 40 [95% CI, 3 to 77] minutes), longer total sleep duration (mean difference, 73 [95% CI, 14 to 131] minutes), fewer nighttime wakings (mean difference, −0.4 [95% CI, −0.6 to −0.1] wakings), and greater likelihood of meeting guidelines of at least 12 hours of total sleep per day (risk ratio [RR], 1.4 [95% CI, 95% CI, 1.1 to 1.8]) than controls. Relative to controls, mothers in the RP group more frequently reported engaging in some RP practices, including giving the baby a few minutes to fall back asleep on their own (RR, 1.6 [95% CI, 1.0 to 2.6]) and being less likely to feed their baby as the last activity before bed (RR, 0.5 [95% CI, 0.3 to 0.8]).

Conclusions and Relevance

This secondary analysis of a randomized clinical trial found that an RP intervention for Black families improved infant sleep and increased some responsive sleep parenting practices.

Trial Registration

ClinicalTrials.gov Identifier: NCT03505203
Artifact removal for unpaired thorax CBCT images using a feature fusion residual network and contextual loss
Authors: Zhuang Wenqin , Li Zheng , Liu Haochen , Ying Hu , Yan Mo
Published: March 2023

Background and objective

Cone‐beam computed tomography (CBCT) has become a more and more active cutting‐edge topic in the international computed tomography (CT) research due to its advantages of fast scanning speed, high ray utilization rate and high precision. However, scatter artifacts affect the imaging performance of CBCT, which hinders its application seriously. Therefore, our study aimed to propose a novel algorithm for scatter artifacts suppression in thorax CBCT based on a feature fusion residual network (FFRN), where the contextual loss was introduced to adapt the unpaired datasets better.

Methods

In the method we proposed, a FFRN with contextual loss was used to reduce CBCT artifacts in the region of chest. Unlike L1 or L2 loss, the contextual loss function makes input images which are not aligned strictly in space available, so we performed it on our unpaired datasets. The algorithm aims to reduce artifacts via studying the mapping between CBCT and CT images, where the CBCT images were set as the beginning while planning CT images as the end.

Results

The proposed method effectively removes artifacts in thorax CBCT, including shadow artifacts and cup artifacts which can be collectively referred to as uneven grayscale artifacts, in the CBCT image, and perform well in preserving details and maintaining the original shape. In addition, the average PSNR number of our proposed method achieved 27.7, which was higher than the methods this paper referred which indicated the significance of our method.

Conclusions

What is revealed by the results is that our method provides a highly effective, rapid, and robust solution for the removal of scatter artifacts in thorax CBCT images. Moreover, as is shown in Table 1, our method has demonstrated better artifact reduction capability than other methods.
Lorlatinib for ALK‐fused, infant‐type hemispheric glioma with lung metastasis: a case report
Authors: Lai Mingyao , Li Shaoqun , Li Hainan , Hu Qingjun , Li Juan , Zhou Jiangfen , Ai Ruyu , Zhen Junjie , Zhou Zhaoming , Wang Lichao , Zhang Yangqiong , Hu Wanming , Yuan Li , Ma Xuejiao , Zhang Xing , Song Chao , Li Zhi , Cai Linbo
Published: March 2023

Infant‐type hemispheric glioma, a new subtype of pediatric high‐grade glioma, arises in the cerebral hemispheres. Despite better survival outcomes, the treatment of infant‐type hemispheric glioma is still facing challenges. Here, we reported a case of QKI‐ALK fusion, infant‐type hemispheric glioma with lung metastasis who achieved a complete clinical response after lorlatinib treatment. This typical case demonstrated the importance of appropriate molecularly targeted treatments in ALK‐fused tumors, and lorlatinib may serve as an effective complement to conventional chemotherapy and radiotherapy in primary glioma harboring ALK fusions and its metastasis.
Hardware‐in‐the‐loop validation of an adaptive model predictive control on a connected and automated vehicle
Authors: Landolfi Enrico , Salvi Alessandro , Troiano Alfredo , Natale Ciro
Published: March 2023

Connected and automated vehicles will characterize the future of the mobility, featured by Smart Roads and Internet of Things technologies. Vehicles will behave as mobile nodes of a network enabling communication between them and with respect to the road infrastructure. In order to provide advanced driver assistance and automated driving along a Smart Road, control strategies need to take into account both parametric variations due to environmental and/or weather conditions (e.g., wind speed, presence of ice, and/or rain), and constraints related to road safety and vehicular traffic. For this reason, advanced adaptive control strategies result particularly suitable to provide a complete control of the vehicle. This article proposes an extension to a previous conference paper, concerning a Processor in the Loop testing of an Adaptive Model Predictive Control for coupled longitudinal/lateral vehicle dynamics, where the ego vehicle was simulated through a bicycle model. In the present work, a low‐cost real‐time Hardware In the Loop test bench, featured by Raspberry boards, is used to verify the control strategy in a way closer to a real application. A four‐wheel vehicle dynamic model is considered to simulate the ego vehicle, then robustness and sensitivity tests with respect to parametric variations related to road friction, wind speed and vehicle mass, and a comparison with an existing adaptive MPC are performed. The achieved results show good robustness properties, safety performances and confirm the real‐time execution of the control strategy, paving the way for future developments, where the goal will be the testing in a real road scenario by using an IoT gateway purposefully designed by the NetCom company.
Controlling the Polarization in Ferroelectric PZT Films via the Epitaxial Growth Conditions
Authors: Sarott Martin F. , Bucheli Ursina , Lochmann Adrian , Fiebig Manfred , Trassin Morgan
Published: March 2023

The integration of thin‐film ferroelectrics with reliable properties into oxide electronics requires accomplishing deterministic polarization states. Since ferroelectricity emerges during thin‐film synthesis already, it is essential to elucidate how the interplay of different growth parameters affects the polarization. Here, the polarization of fully strained Pb(Zr0.2Ti0.8)O3 (PZT) films is accessed in situ, during epitaxial growth. Surprisingly, it is found that the orientation of the out‐of‐plane polarization during growth may differ from the one after growth completion and it strongly depends on the substrate temperature and the oxygen partial pressure. Increasing the growth temperature and/or the oxygen partial pressure favors a uniform downward‐oriented polarization, independent of the direction of polarization during growth. Specifically, for films with an emerging upward‐oriented polarization, a polarization reversal and a downward‐oriented polarization after cool‐down is observed. The in situ measurements obtained by optical second harmonic generation (SHG) in conjunction with ex situ piezoresponse force microscopy (PFM) and X‐ray diffraction (XRD) measurements point to the temperature‐ and pressure‐dependent formation of a charged Pb defect gradient toward the film surface as the responsible mechanism for the polarization reorientation.
Outstanding Fill Factor in Inverted Organic Solar Cells with SnO2 by Atomic Layer Deposition
Authors: Di Mario Lorenzo , Garcia Romero David , Wang Han , Tekelenburg Eelco K. , Meems Sander , Zaharia Teodor , Portale Giuseppe , Loi Maria A.
Published: March 2023

Transport layers are of outmost importance for thin‐film solar cells, determining not only their efficiency but also their stability. To bring one of these thin‐film technologies toward mass production, many factors besides efficiency and stability become important, including the ease of deposition in a scalable manner and the cost of the different material's layers. Herein, highly efficient organic solar cells (OSCs), in the inverted structure (n‐i‐p), are demonstrated by using as electron transport layer (ETL) tin oxide (SnO2) deposited by atomic layer deposition (ALD). ALD is an industrial grade technique which can be applied at the wafer level and also in a roll‐to‐roll configuration. A champion power conversion efficiency (PCE) of 17.26% and a record fill factor (FF) of 79% are shown by PM6:L8‐BO OSCs when using ALD‐SnO2 as ETL. These devices outperform solar cells with SnO2 nanoparticles casted from solution (PCE 16.03%, FF 74%) and also those utilizing the more common sol–gel ZnO (PCE 16.84%, FF 77%). The outstanding results are attributed to a reduced charge carrier recombination at the interface between the ALD‐SnO2 film and the active layer. Furthermore, a higher stability under illumination is demonstrated for the devices with ALD‐SnO2 in comparison with those utilizing ZnO.
Morphology‐Controllable Perovskite‐Like RbCu2Br3 Single Crystals with Strong Photoelectronic Anisotropy for UV Detection
Authors: Ding Ying , Lin Richeng , Zhu Siqi , Lin Zhuogeng , Zheng Wei
Published: March 2023

The carrier transport characteristics of grain boundary‐free, high‐purity metal halide single crystals make them ideal materials for photodetectors. However, the relationship between photoelectric properties and crystal morphology as well as electronic structure is not sufficiently explored. In this work, RbCu2Br3 single crystals with high quality and multiple morphologies are successfully prepared for the first time. Based on angle‐resolved polarized Raman spectroscopy and polarized photoluminescence, the anisotropy of the 1D atomic chain structure of these crystals is identified. Besides, according to the calculation of partial charge density (PCD), electron localization function (ELF), and carrier mobility related to deformation potential theory (DPT), it is found that RbCu2Br3 single crystals have formed a transport path located in [CuBr4] tetrahedral double chain from 1D electronic structure. It is also explored how the factors including electronic constraints, effective mass, mechanical properties, and deformation potential affect the mobility of crystal plane. Moreover, the device constructed on crystal {100} planes has shown great potential for UV detection. This work not only provides a theoretical basis for the performance regulation of RbCu2Br3 single crystals in experiments but also offers scientific guidance for the growth of single crystal materials with an asymmetric structure and for the application of anisotropy‐related optoelectronics.
Soil health tradeoffs may be minimal in phosphorus‐enriched Coastal Plain soils
Authors: Mosesso Lauren R. , Shober Amy L.
Published: March 2023

Soil health practices can improve soil conditions and provide ecosystem services, but increased risk of phosphorus (P) loss can be an unintended consequence. We investigated conservation tillage and cover crops effects on soil P stratification, P accumulation at depth, and soil aggregation for sandy Coastal Plain soils from the Mid‐Atlantic United States soil cores from 10 agricultural fields with 0–15 years of conservation tillage or cover cropping were analyzed for Mehlich‐3 P and dry aggregate stability. We found no evidence that conservation tillage or cover cropping caused P stratification or accumulation in study fields that were already enriched with P prior to soil health implementation. Annual particulate, dissolved runoff, and leachate P loads decreased when estimated using the North Carolina Phosphorus Loss Assessment Tool assuming no‐till and cover crops (soil health) compared to conventional till and winter fallow (conventional). We suggest that soil health practices are unlikely to exacerbate P losses from high P Coastal Plain soils beyond their initial risk profile.
CPR News
Authors: Bleemer Russ
Published: March 2023

Billed as “an event for appointers and appointees,” CPR will present a Washington, D.C., seminar next month, “Driving Toward More Diverse Selection of Neutrals.”
Biases, Accommodations, and the Process Details for Americans with Disabilities Act Mediation
Authors: Cohen Judy , Braun Joan , Frost Lynda , Wood Erica F.
Published: March 2023

Last month, the authors presented an ADA case study on capacity issues, the application of the Model Standards of Conduct for Mediators, and some of the factors that limit a participant's ability to mediate. In this issue's Part 3, the focus is on bias and the need to preserve the parties' self‐determination. The first two parts of this series can be found at “Focusing on the Neutral's Role in Setting Up Americans with Disabilities Act Mediation,” 41 Alternatives 39 (March 2023) (available at https://bit.ly/3EEnWDj), and “ADA Mediation, Updated: Revisiting 30 Years of Disabilities Practice,” 41 Alternatives 19 (February 2023) (available at bit.ly/3jTICQE).
FINRA's Proposal to Amend its Arbitration Rules
Authors: Jedrzejowski Paulina
Published: March 2023

In the wake of a New Jersey law firm's investigation into a claim that FINRA agreed to Wells Fargo's moves in gaming arbitrator selection in a dispute over the bank's investment services, the industry self‐regulatory agency submitted proposed regulations revising arbitrator selection for securities disputes to the U.S. Securities and Exchange Commission.
Radial mesoporous silica supported Eu3+‐functionalized carbon dots for ratiometric tetracycline detection and their polyvinylidene fluoride hybrid film for temperature sensing
Authors: Zhang Ping , Zhang Yuchi , Li Xianliang , Xu Yan
Published: March 2023

A radial mesoporous silica (mSiO2) supported Eu3+‐functionalized carbon dots (CDs) nanocomposite (mSiO2‐CDs‐Eu) was successfully prepared using citric acid as CD precursors, showing specific ratiometric tetracycline (TC) fluorescence sensing behavior. The blue fluorescence of CDs is quenched by the internal filtering effect with TC, and the red fluorescence intensity of Eu3+ ions is improved on account of an antenna effect. The self‐calibrated ratiometric fluorescence sensing of TC by mSiO2‐CDs‐Eu showed a minimum detection limit of 30 nM. In addition, a mSiO2‐CDs‐Eu hybridized polyvinylidene fluoride (PVDF) film was developed for optical temperature sensing with a high‐temperature sensitivity of 1.69% °C−1 in the physiological temperature range of 25–45°C and a temperature resolution greater than 0.04°C. This work demonstrates a feasible way in fabricating dual‐functional mSiO2‐CDs‐Eu nanocomposite with optical ratiometric sensing properties toward both TC and temperature changes, opening its promising applicability for food security and temperature monitoring.
Influence of structure of porous polyketone microfiltration membranes on separation of water‐in‐oil emulsions
Authors: Watanabe Tomoki , Nakagawa Keizo , Gonzales Ralph Rolly , Kitagawa Tooru , Matsuoka Atsushi , Kamio Eiji , Yoshioka Tomohisa , Matsuyama Hideto
Published: March 2023

Pressure‐driven filtration is a suitable alternative to conventional methods for separation of surfactant‐stabilized water‐in‐oil (W/O) emulsions. In this work, porous polyketone (PK) membranes for W/O emulsion separation with outstanding organic solvent resistance were prepared by non‐solvent‐induced phase separation (NIPS). The porous PK membrane structures were controlled by changing the non‐solvent concentration in the coagulation bath. The water contact angle in oil increased as the methanol concentration in the coagulation bath increased because of the formation of a rougher membrane surface, implying higher under‐oil hydrophobicity. The PK membranes were able to separate several surfactant‐stabilized W/O emulsions consisting of various organic solvents, with high oil purity value (99.9%). Permeance increased with increasing methanol concentration in coagulation bath due to the increase in membrane pore size and porosity. The best performing membrane, prepared with 45 wt% methanol coagulation bath, showed over 4000 LMH/bar permeance using emulsions of different particle sizes. Furthermore, the relationship between permeance and the ratio of the PK membrane pore size to the W/O emulsion particle size suggested that the initial permeance was dependent on pore size. The PK membranes demonstrated huge potential for W/O emulsion separation because of their easily‐controlled structures, high under‐oil hydrophobicity, and high separation performance.
Effects of polyamide elastomer on the morphology, crosslink density, mechanical, and oil‐resistant properties of acrylonitrile‐butadiene rubber/polyamide elastomer vulcanizates
Authors: Wang Huiyu , Zhang Xianggong , Liu Guangyong
Published: March 2023

Polyamide elastomer (PAE) is a novel material which may improve the performances of acrylonitrile‐butadiene rubber (NBR). This work uses equilibrium swelling and rheological apparatus to study the effects of the PAE content on the overall crosslink densities of NBR/PAE vulcanizate. The presence of PAE significantly increased the overall crosslink density. During the aging stage, the overall crosslink density first increased and then decreased with increasing aging temperature from 25 to 150°C. There was a linear relationship between the tensile strength with the overall crosslink density of the NBR/PAE vulcanizate. Oil resistance of the NBR/PAE vulcanizate was improved with increasing PAE content.
Molecules interact. But how strong and how much?
Authors: Weimer Kathleen , Zambo Boglarka , Gogl Gergo
Published: March 2023

Interactomics aims to characterize all interactions formed between molecules that comprise our body. Although it emerged from quantitative biophysics, it has devolved into a predominantly qualitative field of science over the past decades. Due to technical limitations at its onset, almost all tools in interactomics are qualitative, which persists in defining the discipline. Here, we argue that interactomics needs to return to a quantitative direction because the technical achievements of the last decade have overcome the original limitations that forced its current path. In contrast to qualitative interactomics which is constrained to charting lists of observed interactions, quantitative interactomics can also uncover answers to key questions such as the strength of interactions or how many of certain complexes can form in cells, thus providing researchers with more immediate proxies for understanding and predicting biological processes.
Comparison of the clinical efficacies of two L‐asparaginase‐based chemotherapy regimens for newly diagnosed nasal‐type extranodal NK/T‐cell lymphoma
Authors: Wu Wanchun , Ren Kexin , Chen Xi , Li Na , Luo Qian , Hai Tao , Zhou Huijie , Zou Liqun
Published: March 2023

Background

Nasal‐type extranodal natural killer (NK)/T cell lymphoma (ENKTL) is a rare and aggressive type of lymphoma. The optimal chemotherapy regimen for ENKTL has not yet been established. In this study, we compared the LVDP (L‐asparaginase, etoposide, dexamethasone, and cisplatin) and GLIDE (gemcitabine, L‐asparaginase, ifosfamide, dexamethasone, and etoposide) chemotherapy regimens for the treatment of ENKTL.

Methods

A total of 267 patients with newly diagnosed ENKTL were included in this retrospective study. Propensity score matching (PSM) was used to adjust for confounders between the LVDP and GLIDE groups. Treatment responses, survival outcomes, and toxicities between the two groups were compared before and after PSM.

Results

At the end of therapy, the objective response rate (ORR) and complete response (CR) were 83.5% and 62.2%, respectively, for all patients. The ORR and CR were 85.5% and 62.2% for the LVDP group compared with 79.3% and 62.2% for the GLIDE group, respectively, and no differences between the two groups were found (ORR, p = 0.212; CR, p = 0.996). With a median 71 months follow‐up, the 5‐year progression‐free survival (PFS) and overall survival (OS) rates were 64.3% and 68.5%, respectively. The 5‐year PFS and OS were 65.6% and 70.1% for the LVDP group compared with 61.6% and 64.6% for the GLIDE group, respectively (PFS, p = 0.478; OS, p = 0162). After PSM, no significant differences in short‐term efficacy (ORR, p = 0.696; CR, p = 0.264) or long‐term efficacy (PFS, p = 0.794; OS, p = 0.867) between the two groups were identified. However, treatment‐related toxicities were milder in the LVDP group compared to the GLIDE group, even after adjusting for confounders via PSM.

Conclusion

In conclusion, both LVDP and GLIDE regimens are effective for the treatment of ENKTL. However, the LVDP regimen is safer than the GLIDE regimen, with milder treatment‐related toxicities. Therefore, the LVDP regimen could be a preferable option for patients with ENKTL.
Human papillomavirus testing on self‐collected samples to detect high‐grade cervical lesions in rural Bhutan: The REACH‐Bhutan study
Authors: Clifford Gary M. , Baussano Iacopo , Heideman Daniëlle A. M. , Tshering Sangay , Choden Tashi , Lazzarato Fulvio , Tenet Vanessa , Franceschi Silvia , Darragh Teresa M. , Tobgay Tashi , Tshomo Ugyen
Published: March 2023

Background

“REACH‐Bhutan” aimed to evaluate the feasibility and clinical performance of a community‐based screening program for cervical cancer in rural Bhutan using self‐collected samples for high‐risk human papillomavirus (HR‐HPV) testing.

Methods

In April/May 2016, 2590 women aged 30–60 years were screened across rural Bhutan by providing a self‐collected sample for careHPV testing. All careHPV‐positive women, plus a random sample of careHPV‐negative women, were recalled for colposcopy and biopsy. Self‐samples also underwent GP5+/6+ polymerase chain reaction (PCR)‐based HR‐HPV DNA detection and genotyping. Cross‐sectional screening indices were estimated against histological high‐grade squamous intraepithelial lesions or worse (hHSIL+), including imputation of hHSIL+ in women without colposcopy.

Results

HR‐HPV positivity was 10.2% by careHPV and 14.8% by GP5+/6+ PCR. Twenty‐two cases of hHSIL+ were histologically diagnosed, including one invasive cancer; an additional 7 hHSIL+ were imputed in women without colposcopy. HR‐HPV testing by GP5+/6+ showed higher sensitivity for hHSIL+ (89.7%, 95% CI 72.6–97.8) than careHPV (75.9%, 95% CI 56.5–89.7). Negative predictive value was also slightly higher for GP5+/6+ (99.9%, 95% CI 99.6–100) than careHPV (99.7%, 95% CI 99.4–99.9). Specificity, however, was lower for GP5+/6+ (86.1%, 95% CI 84.6–87.4) than careHPV (90.6%, 95% CI 89.4–91.7), as was positive predictive value (6.9%, 95% CI 4.5–9.9 vs. 8.5%, 95% CI 5.4–12.6). Of 377 HR‐HPV‐positive women by GP5+/6+, 173 (45.9%) were careHPV‐positive, including 54.7% HPV16‐positive and 30.2% HPV18‐positive women.

Conclusions

The final REACH‐Bhutan results show that screening for cervical cancer with self‐collection of samples and HR‐HPV testing, in addition to our previous report of achieving high participation, can also perform well to detect women with hHSIL+.
Encapsulated papillary carcinoma of the breast: An institutional case series and literature review
Authors: Tan Hiang Jin , Tan Puay Hoon , Leong Lester Chee Hao , Tan Veronique Kiak Mien , Tan Benita Kiat Tee , Lim Sue Zann , Preetha Madhukumar , Wong Chow Yin , Yong Wei Sean , Sim Yirong
Published: March 2023

Background

Encapsulated papillary carcinoma of the breast is rare, making difficult diagnosis and resulting in patients undergoing excision biopsy before definitive surgery. Evidence‐based guidelines are sparse. We would like to further elucidate the clinicopathological, treatment and survival outcomes.

Materials and Methods

54 patients identified, with a median follow up duration of 48 months. Patients' demographics, radiological and clinicopathological characteristics, treatment, adjuvant therapies as well as survival data were analysed.

Results

18 (33.3%) cases were pure EPC, 12 (22.2%) were EPC associated with ductal carcinoma in situ (DCIS) and 24 (44.4%) cases had concurrent invasive ductal carcinoma. EPCs were more likely to present as a solid‐cystic mass on sonography (63.8%), regular‐shaped (oval or round) (97.9%), lack spiculations (95.7%) and lack suspicious microcalcifications (95.6%). Median tumour size was largest in the EPC with IDC group (18.5 mm). 2 patients developed loco‐regional recurrence. Overall survival is good for EPCs of all subtypes.

Conclusion

EPC is a rare tumour with excellent prognosis.