bluuebunny/crossref_metadata_2025 huggingface dataset:
A Measure of Suffering in relation to Anxiety and Quality of Life in IBS Patients: Preliminary Results
Authors: Pletikosić Tončić Sanda , Tkalčić Mladenka
Published: July 2017

Irritable bowel syndrome (IBS) is a chronic gastrointestinal (GI) disorder with a severe impact on quality of life (QoL). We explored the relationship of a visual measure of suffering, the PRISM-RII, with quality of life (QoL) and anxiety measures in IBS patients. Participants were 44 IBS patients who completed several questionnaires and kept a symptom diary for two weeks. The measures used were PRISM-RII (self-illness separation (SIS); illness perception measure (IPM)); IBS-36 (IBS health related QoL); SF-36 (physical and mental health related QoL); State-Trait Anxiety Inventory (STAI-T); Visceral Sensitivity Index (VSI; GI-specific anxiety); and a symptom diary. SIS was negatively correlated to VSI, while IPM was negatively correlated to SIS and the physical component of SF-36 and positively to VSI and symptom severity. We found significant differences between participants who perceive their illness as small and those who perceive it as medium in SIS, symptom severity, VSI, and the mental component of SF-36. Participants, who perceived their illness as small, represented their illness as more distant, showed lower average symptom severity, and had lower GI-specific anxiety and higher QoL. The results indicate that IPM and SIS can be useful in discriminating patients with more prominent psychological difficulties and QoL impairment.
Influence of Palm Oil Fuel Ash and W/B Ratios on Compressive Strength, Water Permeability, and Chloride Resistance of Concrete
Authors: Sanawung Wachilakorn , Cheewaket Tieng , Tangchirapat Weerachart , Jaturapitakkul Chai
Published: July 2017

This research studies the effects of W/B ratios and palm oil fuel ash (POFA) on compressive strength, water permeability, and chloride resistance of concrete. POFA was ground until the particles retained on sieve number 325 were less than 5% by weight. POFA was used to partially replace OPC at rates of 15, 25, and 35% by weight of binder. The water to binder (W/B) ratios of concrete were 0.40 and 0.50. The compressive strength, water permeability, and chloride resistance of concrete were investigated up to 90 days. The results showed that POFA concrete with W/B ratio of 0.40 had the compressive strengths ranging from 45.8 to 55.9 MPa or 82–94% of OPC concrete at 90 days, while POFA concrete with W/B ratio of 0.50 had the compressive strengths of 33.9–41.9 MPa or 81–94% of OPC concrete. Furthermore, the compressive strength of concrete incorporation of ground POFA at 15% was the same as OPC concrete. The water permeability coefficient and the chloride ion penetration of POFA concrete were lower than OPC concrete when both types of concrete had the same compressive strengths. The findings also indicated that water permeability and chloride ion penetration of POFA concrete were significantly reduced compared to OPC concrete.
Are There Modifiable Risk Factors to Improve AKI?
Authors: Nie Sasa , Tang Li , Zhang Weiguang , Feng Zhe , Chen Xiangmei
Published: July 2017

Acute kidney injury (AKI) is a common critical syndrome, with high morbidity and mortality. Patients with AKI typically have an adverse prognosis, from incident chronic kidney disease (CKD), progression to end-stage renal disease (ESRD), subsequent cardiovascular disease, and ultimately death. However, there is currently no effective therapy for AKI. Early detection of risk factors for AKI may offer a good approach to prevention or early intervention. Traditional risk factors include extreme age, many common comorbid diseases, such as preexisting CKD, some specific exposures, such as sepsis, and exposure to some nephrotoxic agents. Recently, several novel risk factors for AKI, such as hyperuricemia, hypoalbuminemia, obesity, anemia, and hyperglycemia, have been identified. The underlying mechanisms between these nontraditional risk factors and AKI and whether their correction can reduce AKI occurrence remain to be clarified. This review describes the current epidemiology of AKI, summarizes its outcome, outlines the traditional risk profile, and finally highlights some recently identified novel risk factors.
Computational Flow Dynamic Simulation of Micro Flow Field Characteristics Drainage Device Used in the Process of Oil-Water Separation
Authors: Jin Guangya , Liu Zhijian
Published: July 2017

Aqueous crude oil often contains large amounts of produced water and heavy sediment, which seriously threats the safety of crude oil storage and transportation. Therefore, the proper design of crude oil tank drainage device is prerequisite for efficient purification of aqueous crude oil. In this work, the composition and physicochemical properties of crude oil samples were tested under the actual conditions encountered. Based on these data, an appropriate crude oil tank drainage device was developed using the principle of floating ball and multiphase flow. In addition, the flow field characteristics in the device were simulated and the contours and streamtraces of velocity magnitude at different nine moments were obtained. Meanwhile, the improvement of flow field characteristics after the addition of grids in crude oil tank drainage device was validated. These findings provide insights into the development of effective selection methods and serve as important references for oil-water separation process.
Polypropylene Carbon Nanotubes Nanocomposites: Combined Influence of Block Copolymer Compatibilizer and Melt Annealing on Electrical Properties
Authors: Emplit Aline , Tao Fang Fang , Lipnik Pascale , Heunen Guido , Bailly Christian , Huynen Isabelle
Published: July 2017

We study the influence of melt annealing and the presence of a block copolymer compatibilizer on the electrical properties of polypropylene carbon nanotubes (CNT) nanocomposites from the DC limit to microwave frequencies and link it to the morphological details. We show that the compatibilizer concentration controls three types of morphologies: separate CNT agglomerates, a network of well dispersed but interconnected CNT, and individualized but separate nanotubes. This explains why conductivity reaches an optimum over the whole frequency range at a low compatibilizer concentration. We model the corresponding structures by a semiquantitative schematic equivalent electrical circuit. A key outcome of the work is the understanding and control of dispersion mechanisms in order to optimize the electrical performances for efficient EMI shielding depending on the targeted frequency range.
MultiP-Apo: A Multilabel Predictor for Identifying Subcellular Locations of Apoptosis Proteins
Authors: Wang Xiao , Li Hui , Wang Rong , Zhang Qiuwen , Zhang Weiwei , Gan Yong
Published: July 2017

Apoptosis proteins play an important role in the mechanism of programmed cell death. Predicting subcellular localization of apoptosis proteins is an essential step to understand their functions and identify drugs target. Many computational prediction methods have been developed for apoptosis protein subcellular localization. However, these existing works only focus on the proteins that have one location; proteins with multiple locations are either not considered or assumed as not existing when constructing prediction models, so that they cannot completely predict all the locations of the apoptosis proteins with multiple locations. To address this problem, this paper proposes a novel multilabel predictor named MultiP-Apo, which can predict not only apoptosis proteins with single subcellular location but also those with multiple subcellular locations. Specifically, given a query protein, GO-based feature extraction method is used to extract its feature vector. Subsequently, the GO feature vector is classified by a new multilabel classifier based on the label-specific features. It is the first multilabel predictor ever established for identifying subcellular locations of multilocation apoptosis proteins. As an initial study, MultiP-Apo achieves an overall accuracy of 58.49% by jackknife test, which indicates that our proposed predictor may become a very useful high-throughput tool in this area.
Application of Artificial Neural Networks to Calculation of Oil Film Reaction Forces and Dynamics of Rotors on Journal Bearings
Authors: Kornaev Alexey V. , Kornaev Nickolay V. , Kornaeva Elena P. , Savin Leonid A.
Published: July 2017

Increase of energy efficiency and level of information system development of rotor machines in general requires improvement of theoretical approaches to research. In the present paper the problem of high-precision and high-performance computing programs development has been considered to simulate rotor vibrations. Based on two-layer feed-forward neural networks, numerical models have been developed to calculate oil film reaction forces to solve the rotor dynamics problems. Comparison has been done of linear and nonlinear approaches to solution of rotor dynamics problems, and a qualitative evaluation has been presented of accuracy and performance of a neural network approach compared to conventional approaches to rotor dynamics.
Morphological Analysis of Bronchial Arteries and Variants with Computed Tomography Angiography
Authors: Esparza-Hernández Claudia Nallely , Ramírez-González Juan Manuel , Cuéllar-Lozano Rolando Alberto , Morales-Avalos Rodolfo , González-Arocha Carla Sofía , Martínez-González Brenda , Quiroga-Garza Alejandro , Pinales-Razo Ricardo , Elizondo-Riojas Guillermo , Elizondo-Omaña Rodrigo Enrique , Guzmán-López Santos
Published: July 2017

The aim of our study was to determine the prevalence of anatomical variants of bronchial arteries using computed tomographic angiography in a population of northeastern Mexico. An observational, transversal, descriptive, comparative, retrospective study was performed using 139 imaging studies of Mexican patients in which we evaluated the following parameters from the left and right bronchial arteries: artery origin, branching pattern, arterial ostium, vertebral level of origin, diameter, and mediastinal trajectory. The anatomies of the bronchial arteries were similar in both genders, except distribution for vertebral origin level (p  0.006) and the diameter (p  0.013). Left and right arteries were similar, except for the mediastinal trajectory in reference to the esophagus (p<0.001) as well as the arterial diameter (p<0.001) and lumen diameter.
Intratumoral STING Activation with T-cell Checkpoint Modulation Generates Systemic Antitumor Immunity
Authors: Ager Casey R. , Reilley Matthew J. , Nicholas Courtney , Bartkowiak Todd , Jaiswal Ashvin R. , Curran Michael A.
Published: July 2017

Coordinated manipulation of independent immune regulatory pathways in the tumor microenvironment—including blockade of T-cell checkpoint receptors and reversal of suppressive myeloid programs—can render aggressive cancers susceptible to immune rejection. Elevated toxicity associated with combination immunotherapy, however, prevents translation of the most efficacious regimens. We evaluated T-cell checkpoint–modulating antibodies targeting CTLA-4, PD-1, and 4-1BB together with myeloid agonists targeting either STING or Flt3 in the TRAMP-C2 model of prostate cancer to determine whether low-dose intratumoral delivery of these agents could elicit systemic control of multifocal disease. Intratumoral administration of the STING agonist cyclic di-GMP (CDG) or Flt3 Ligand (Flt3L) augmented the therapeutic effect of systemic triple checkpoint modulation and promoted the cure of 75% of mice with bilateral TRAMP-C2; however, when all agents were administered locally, only CDG mobilized abscopal immunity. Combination efficacy correlated with globally enhanced ratios of CD8+ T cells to regulatory T cells (Treg), macrophages, and myeloid-derived suppressor cells, and downregulation of the M2 marker CD206 on tumor-associated macrophages. Flt3L improved CD8+ T-cell and dendritic cell infiltration of tumors, but was diminished in efficacy by concomitant Treg expansion. Although intratumoral CDG/checkpoint therapy invokes substantial ulceration at the injection site, reduced CDG dosing can preserve tissue integrity without sacrificing therapeutic benefit. For high-order combinations of T-cell checkpoint antibodies and local myeloid agonists, systemic antibody administration provides the greatest efficacy; however, local administration of CDG and antibody provides substantial systemic benefit while minimizing the potential for immune-related adverse events. Cancer Immunol Res; 5(8); 676–84. ©2017 AACR.
Retinoblastoma: A Sixteen-Year Review of the Presentation, Treatment, and Outcome from a Tertiary Care Institute in Northern India
Authors: Singh Usha , Katoch Deeksha , Kaur Savleen , Dogra Mangat Ram , Bansal Deepak , Kapoor Rakesh
Published: July 2017

Purpose: To study epidemiology, demographic profile, clinical characteristics, and outcome in pediatric patients with retinoblastoma. Methods: This was a retrospective review of retinoblastoma patients of a tertiary institute from January 1st 1998 to December 31st 2014. Results: The study included 467 patients (618 eyes) with a mean age of 34.7 ± 24.6 months (median = 30; 15 days to 144 months). Retinoblastoma was bilateral in 151 (32.3%) and there were 61.7% males. Intraocular disease was seen in 301 patients (451 eyes [72.9%]) and extraocular in 166 patients (167 eyes; 27.0%). Out of the 347 (74.3%) who received treatment, primary treatment was chemoreduction in 228 (65.7%) and enucleation in 117 (33.7%), while 25.6% of patients refused treatment and 151 (43.5%) defaulted therapy. Local recurrence was seen in 20 (4.3%), metastasis in 2 (0.4%), and deaths in 13 (2.8%) (average follow-up 28.5 ± 44.4 months). Histopathological high risk features were significantly less in the eyes that received chemoreduction (5.0%) versus primary enucleation (20.8%) (p < 0.0004), but there was no difference in the rate of metastasis, recurrence, and death between the two. Conclusions: The majority of retinoblastoma patients in our study had advanced disease, and nearly a third had extraocular extension. There were a significant number of therapy refusals and dropouts. Chemoreduction led to a significant decrease in the histopathological risk factors without affecting the outcomes.
Impact of Individual Components of the Metabolic Syndrome on the Outcome of Patients with Advanced Hepatocellular Carcinoma Treated with Sorafenib
Authors: Labenz Christian , Prenosil Vera , Koch Sandra , Huber Yvonne , Marquardt Jens U. , Schattenberg Jörn M. , Galle Peter R. , Weinmann Arndt , Wörns Marcus-Alexander
Published: July 2017

Background/Aim: Individual components of the metabolic syndrome (MS) such as obesity or diabetes mellitus impair the prognosis of patients with hepatocellular carcinoma (HCC) following curative treatment approaches or transarterial therapies. The aim of this retrospective study was to assess the impact of these factors on the overall survival (OS) of patients with advanced HCC treated with sorafenib. Methods: Univariate and multivariate analyses were performed to assess the impact of individual components of the MS on the OS of 152 consecutive patients with advanced HCC treated with sorafenib. Results: The presence of overweight/obesity, type 2 diabetes mellitus, hypertension, dyslipidemia, and of the MS itself did not impair the median OS. Multivariate analysis showed that Eastern Cooperative Oncology Group Performance Status ≥1 (hazards ratio [HR] 2.03), presence of macrovascular invasion (HR 1.71), Child-Pugh score B/C (HR 2.19), tumor grading G3 (HR 2.17), no prior HCC treatment (HR 2.34), and the presence of 2 or more out of 5 individual components of the MS (HR 0.65) were independent prognostic factors regarding the median OS. Conclusions: Our investigations do not confirm a negative prognostic role of individual components of the MS or the MS itself for patients with advanced HCC treated with sorafenib.
The Diagnostic Value of IGF-2 and the IGF/IGFBP-3 System in Silver-Russell Syndrome
Authors: Binder Gerhard , Eggermann Thomas , Weber Karin , Ferrand Nawfel , Schweizer Roland
Published: July 2017

Background/Aims: Recently, we have described a family of 4 members presenting with intrauterine and postnatal growth failure, low IGF-2 levels, and signs of Silver-Russell syndrome (SRS) who carried a genomic IGF2 mutation. Here, we assess the value of IGF-2 in relation to SRS. Methods: We collected data from 48 SRS children and 48 short children born small for gestational age (SGA) seen at our center. The SRS children were 4.6 ± 2.0 years of age, and the SGA children were 4.8 ± 1.8 years of age. All patients were prepubertal and growth hormone naive. An 11p15 ICR1 loss of methylation (11p15LOM) was present in 22, maternal uniparental disomy of chromosome 7 (upd(7)mat) in 7, and IGF2 genomic mutation (IGF2mut) in 3 patients. Growth factors were measured by in-house radioimmunoassays. Results: The median IGF-2 standard deviation scores (SDSs) were: IGF2mut –1.75, upd(7)mat –1.69, nonsyndromic SGA –1.52, 11p15LOM –0.61, and clinical (tested negative) –0.55. The median IGF-2:IGF-1 concentration ratio was 2.57 in IGF2mut compared to 5.44 in 11p15LOM (p = 0.036), 7.84 in clinical, and 7.98 in upd(7)mat. Upd(7)mat patients had significantly lower IGF-1 and IGFBP-3 SDSs than patients with 11p15LOM (p ≤ 0.002). Conclusion: Serum IGF-2 in combination with IGF-1 and IGFBP-3 can add to the clinical signs of SRS patients and help to perform targeted genetic testing. Further studies are needed.
Relapsed Multiple Myeloma Presenting as Intracranial Plasmacytoma and Malignant Pericardial Effusion following Recent Allogeneic Stem Cell Transplantation
Authors: Pan Jonathan , Chen Jason , Filicko Joanne , Grosso Dolores , Nagurney Michelle , Alpdogan Onder , Flomenberg Neal
Published: July 2017

Although rare, both central nervous system and pericardial involvement of myeloma have been well described in the literature. Their simultaneous occurrence in relapsed disease, however, has not been previously reported. This case describes a 54-year-old female who was treated for high-risk multiple myeloma with multiregimen chemotherapy and allogeneic hematopoietic stem cell transplantation. Four months after transplant, she was found to have relapsed disease manifesting as an extraosseous, intracranial plasmacytoma and simultaneous malignant pericardial effusion. Her disease characteristics, treatment course, radiologic and pathologic findings are described in detail, and we review the previous literature to determine the various aspects of her disease that may have contributed to her aggressive clinical course.
International Society for the Study of Fatty Acids and Lipids 2016 Debate: For Science-Based Dietary Guidelines on Fats, Meta-Analysis and Systematic Reviews Are Decisive
Authors: Nettleton Joyce A. , von Schacky Clemens , Brouwer Ingeborg A. , Koletzko Berthold
Published: July 2017

This paper summarizes a debate on whether meta-analyses and systematic reviews are decisive in formulating guidelines for dietary fat. Held during the 12th congress of the International Society for the Study of Fatty Acids and Lipids in Stellenbosch, South Africa, September 7, 2016, the debate was hosted by the International Union of Nutritional Sciences and the International Expert Movement to Improve Dietary Fat Quality (IEM, www.theiem.org). Clemens von Schacky, Ludwig Maximilians-University, Munich, Germany, supported the statement, describing the types of weaknesses in individual studies and clinical trials. With examples of how to overcome such limitations, he concluded that nutritional guidelines on fat need a proper scientific basis in which randomized controlled trials (RCTs) with clinical endpoints and their meta-analyses are essential and decisive. In contention, Ingeborg Brouwer, Vrije Universiteit, Amsterdam, declared that recommendations on dietary fat intake should always be based on the totality of the evidence, including physiologic and biochemical knowledge and associations from observational epidemiology. RCTs and meta-analyses have their shortcomings, but well-conducted systematic reviews and meta-analyses support a transparent process for developing dietary fat guidelines. Participants agreed that evidence-based decision-making for dietary guidance should consider all the best available evidence using a transparent, systematic review.
ДОСЛІДЖЕННЯ ГЕПАТОПРОТЕКТОРНОЇ АКТИВНОСТІ РІДКОГО ЕКСТРАКТУ ТРАВИ ЧАБЕРУ САДОВОГО ПРИ ТЕТРАХЛОРМЕТАНОВОМУ ГЕПАТИТІ
Authors: Shanaida M. I. , Oleshchuk O. M. , Lykhatskyi P. H. , Kernychna I. Z.
Published: July 2017

Мета роботи. Вивчити гепатопротекторну активність рідкого екстракту трави чаберу садового (Sаturejа hortensis L.) при експериментальному гострому тетрахлорметановому гепатиті.Матеріали і методи. Рідкий екстракт виготовлено шляхом послідовної екстракції подрібненої трави чаберу садового спиртом етиловим (70 %, 50 % та 30 %) з наступним об’єднанням витягів та їх концентруванням; його дозування здійснювали в перерахунку на сухий залишок. Для моделювання гепатиту щурам дворазового вводили 50 % олійний розчин тетрахлорметану у дозі 1 мл/кг маси тіла тварин. Для вивчення гепатопротекторної дії рідкого екстракту трави чаберу садового були вибрані дози 50 мг/кг, 100 мг/кг і 200 мг/кг маси тіла тварин; як препарат порівняння використовували «Силібор» у дозі 50 мг/кг.Результати й обговорення. Введення піддослідним тваринам рідкого екстракту трави чаберу садового з профілактичною метою на тлі тетрахлорметанового отруєння значно зменшило загальні прояви ураження. У ході експерименту вижили всі щури, які отримували екстракт, що вказує на перспективність вивчення його гепатопротекторної дії. Найбільш вірогідні зміни у досліджуваних біохімічних показниках організму щурів встановлено при використанні екстракту у дозі 200 мг/кг: за впливом на вміст малонового діальдегіду, молекул середньої маси та коефіцієнт маси печінки досліджуваний екстракт достовірно не відрізнявся від референс-препарату «Силібор», а за такими біохімічними показниками, як вміст загального білка і активністю супероксиддисмутази достовірно його перевершував. Використання доз екстракту 50 мг/кг і 100 мг/кг проявляло достовірний позитивний ефект тільки на деякі досліджувані показники уражених тварин.Висновки. Профілактичне введення рідкого екстракту трави чаберу садового у дозі 200 мг/кг ураженим тетрахлорметаном щурам суттєво знижувало інтенсивніть ураження печінки порівняно з контрольною патологією.
IDENTIFICATION AND QUANTITATIVE DETERMINATION OF FLAVONOID IN AGRIMONIA EUPATORIA
Authors: Kozak I. V. , Vronska L. V. , Demyd A. E. , Hroshovyi T. A.
Published: July 2017

Мета роботи. Встановлення відповідності якісного складу флавоноїдів вітчизняних зразків трави парила звичайного вимогам, наведеним у ДФУ для квітучих верхівок парила та розробка методики кількісного визначення суми флавоноїдів у ній.Матеріали і методи. Для дослідження якісного складу флавоноїдів використано чотири вітчизняні зразки трави парила звичайного, в п’яти зразках проводили оцінку кількісного вмісту флавоноїдів. У роботі використано тонкошарову хроматографію при вивченні якісного складу і спектрофотометрію при визначенні кількісного вмісту флавоноїдів.Результати й обговорення. Проведені дослідження вказали на відповідність якісного складу флавоноїдів трави парила звичайного вимогам ДФУ для парила квітучих верхівок. Для встановлення тотожності трави парила звичайного запропоновано ідентифікувати флавоноїди методом тонкошарової хроматографії, змінивши пробопідготовку сировини. У розчин порівняння додатково слід вносити гіперозид, щоб однозначно ідентифікувати його на хроматограмі випробовуваного розчину. В електронних спектрах поглинання, отриманих для спиртових витягів (70 %, об/об) з трави парила звичайного в умовах комплексоутворення з алюміній хлоридом, максимум поглинання спостерігається в діапазоні 400-403 нм. Зважаючи на це, запропоновано методику кількісного визначення суми флавоноїдів у перерахунку на лютеолін або лютеолін-7-О-глюкозид, використовуючи значення питомих коефіцієнтів поглинання комплексних сполук вказаних флавоноїдів з алюміній хлоридом.Висновки. Ідентифікаційними маркерами трави парила обрано рутин, гіперозид, ізокверцитрин; передбачено можливість присутності кверцитрину та інших флавоноїдів з некверцетиновими агліконами і фенолкарбонових кислот у вигляді зон оранжевої, зеленої і блакитної флуоресценції на хроматограмі випробовуваного розчину. Вміст флавоноїдів у досліджуваних п'яти зразках знаходився у межах 0,90-1,46 % у перерахунку на лютеолін або 1,47-2,39 % у перерахунку на лютеолін-7-О-глюкозид. Відмінність значень вмісту для різних зразків пов'язується як з різними умовами зростання сировини, так і з невизначеністю поняття «трава». Тому є потреба у введенні національної частини в монографію ДФУ на парило, в якій передбачити застосування трави парила, а також ввести показник «Сторонні домішки» із критерієм граничного вмісту грубих стебел. Зважаючи на високий вміст і біологічну активність флавоноїдів, у монографії для трави парила слід запровадити визначення вмісту флавоноїдів.
ВИВЧЕННЯ УМОВ ІЗОЛЮВАННЯ ЗИПРАЗИДОНУ З ОБ’ЄКТІВ БІОЛОГІЧНОГО ПОХОДЖЕННЯ
Authors: Davidovich S. I. , Halkevych I. J.
Published: July 2017

Мета роботи. Зипразидон широко використовують для лікування як позитивних, так і негативних симптомів шизофренії. При передозуванні чи комбінуванні його з лікарськими засобами, що викликають пролонгацію інтервалу QT, спостерігається кардіотоксична дія препарату. Серцево-судинні порушення, що виникають при цьому, нерідко стають причиною летальних випадків. Тому метою роботи було розробити оптимальні умови виділення та визначення зипразидону в біологічному матеріалі для експрес-діагностики отруєнь даним препаратом.Матеріали і методи. Виділення зипразидону із об’єктів біологічного походження проводили сумішшю ацетонітрил – 70 % перхлоратна кислота (1:1) з наступною рідинною екстракцією препарату хлороформом (рН 11). Для очистки екстрактів із біологічних проб застосовували картриджі для твердофазної екстракції Strata X 30 mg (Phenomenex). Ідентифікацію та кількісне визначення зипразидону в етанольних розчинах та екстрактах із біологічного матеріалу проводили методом спектрофлуориметрії. Інтенсивність флуоресценції вимірювали на спектрофлуориметрі Hitachi MPF4 (Японія) у кварцових односантиметрових кюветах при 25 °С.Результати й обговорення. Ефективність ізолювання зипразидону з модельних проб печінки водою, підкисленою оксалатною кислотою, є недостатньою - виділено 34 - 36,1 % зипразидону. Кращі результати було одержано при настоюванні біологічного матеріалу з сумішшю ацетонітрил - 70 % перхлоратна кислота (1:1). При цьому було досягнуто ступеня ізолювання зипразидону 71,3 - 74,1 %. Межа кількісного визначення зипразидону запропонованим методом становить 0,15 мкг препарату в 1 г біологічного матеріалу при відносній похибці ± 1,39%. Встановлено, що спектр флуоресценції зипразидону в 96 % етанолі характеризується максимумом збудження при довжині хвилі Лз6= 320 нм та максимумом випромінювання Лем при 400 нм. У межах концентрацій зипразидону від 200 до 800 нг/мл калібрувальний графік описується залежністю Y=0.128xX-5.60078 (r=0,9996), а в діапазоні концентрацій від 0,8 - 40,0 мкг/мл кількісний вміст препарату визначають за рівнянням прямої виду Y=2.55478xX+6.63262 (r=0,9995).Висновки. Розроблено умови ідентифікації та кількісного визначення зипразидону у витяжках із біологічного матеріалу методом флуоресцентної спектроскопії. Розроблений спосіб ізолювання препарату може бути рекомендований для впровадження в роботу судово-медичних експертиз при діагностиці отруєнь зипразидоном.
ДОСЛІДЖЕННЯ РОЛІ ПСИХОЛОГІЧНОГО СТИМУЛЮВАННЯ ПЕРСОНАЛУ В СОЦІАЛЬНОМУ МЕНЕДЖМЕНТІ ФАРМАЦЕВТИЧНИХ ОРГАНІЗАЦІЙ
Authors: Kotvitskaya A. A. , Voronina О. N. , Kubareva I. V. , Chmihalo N. V.
Published: July 2017

Мета роботи. Проведення дослідження ролі психологічного стимулювання персоналу в соціальному менеджменті фармацевтичних організацій.Матеріали і методи. Використано методи наукового аналізу, зокрема його прийоми узагальнення та групування, а також соціологічні методи дослідження.Результати й обговорення. У ході проведення дослідження зазначено психологічні методи соціального менеджменту, фактори психологічного стимулювання персоналу та визначено наступне: 68,9 % опитаних працівників вказали, що в практичній діяльності фармацевтичних організацій не повною мірою використовуються психологічні прийоми стимулювання персоналу, недостаньо використовується метод щодо формування робочих груп за критерієм психологічної сумісності працівників (72,8 %) та майже зовсім не використовується психологічно-організаційний метод стимулювання персоналу (86,6 %), тобто при організаційному нормуванні та регламентуванні праці майже не враховується індивідуальна психологія працівника.Висновки. Результати дослідження свідчать про зростання ролі саме психологічного стимулювання персоналу в соціальному менеджменті фармацевтичних організацій, що пояснюється змінами змісту сучасної суспільної праці, її інтелектуалізації та зростанням соціально-культурного й професійного рівня працівників. Визначено, що обов’язковою необхідністю є цінування кожного працівника як окремої особистості, як важливого члена колективу фармацевтичної організації, що має спільні цілі та йде до конкретної мети. Психологічне стимулювання персоналу обов’язково повинно бути застосоване в управлінні фармацевтичною організацією з метою підвищення соціальної активності співробітників.
СИНТЕЗ ТА ПРОТИПУХЛИННА АКТИВНІСТЬ 6-(Н/Ме)-N-(5-R-БЕНЗИЛ-1,3-ТІАЗОЛ-2-ІЛ)-4,5,6,7-ТЕТРАГІДРО-1- БЕНЗОТІОФЕН-3-КАРБОКСАМІДІВ
Authors: Ostapiuk Yu. V. , Frolov D. A. , Matiychuk V. S.
Published: July 2017

Мета роботи. Синтез нових 6-(Н/Ме)-N-(5-R-бензил-1,3-тіазол-2-іл)-4,5,6,7-тетрагідро-1-бензотіофен-3-карбокса-амідів та дослідження їх протипухлинної активності.Матеріали і методи. При виконанні експериментальної частини роботи використано традиційні методи органічного синтезу. Вихідні реагенти синтезовані за відомими методиками із комерційно доступних реактивів. Спектри ЯМР одержаних сполук знімали на приладі Varian VXR-400, розчинник DMSO-d6, стандарт – тетраметилсилан. Вивчення протипухлинної активності синтезованих сполук виконували в рамках міжнародної наукової програми DTP (Developmental Therapeutic Program) Національного інституту раку (NCI, Бетезда, Меріленд, США).Результати й обговорення. Отримано серію нових 6-(Н/Ме)-N-(5-R-бензил-1,3-тіазол-2-іл)-4,5,6,7-тетрагідро-1-бензотіофен-3-карбоксамідів (5а-h). Досліджено протипухлинну активність  N-[5-(3-хлоробензил)-1,3-тіазол-2-іл]-4,5,6,7-тетрагідро-1-бензотіофен-3-карбоксаміду (5b),  N-(5-бензил-1,3-тіазол-2-іл-6-метил-4,5,6,7-тетрагідро-1-бензотіофен-3-карбоксаміду (5d) та 6-мeтил-N-{5-[2-хлоро-5-(трифторометил)бензил]-1,3-тіазол-2-іл}-4,5,6,7-тетрагідро-1-бензотіофен-3-карбоксаміду (5h). Встановлено, що сполуки 5b і 5d володіють значним протипухлинним ефектом.Висновки. Вперше отримано серію нових 6-(Н/Ме)-N-(5-R-бензил-1,3-тіазол-2-іл)-4,5,6,7-тетрагідро-1-бензотіофен-3-карбоксамідів (5а-h). Досліджено їх протипухлинну активність. Ідентифіковано сполуки-хіти, перспективні для подальшої оптимізації.
Manual do Estagiário e Portaria de Estágio: Elementos de Unidade na Diversidade do Estágio Curricular da FE-USP
Authors: Ribeiro Renato Melo , Andrade Afonso Martins
Published: July 2017

Este relato de experiência tem por objetivo apresentar brevemente duas importantes iniciativas desenvolvidas no âmbito do Programa de Formação de Professores da Faculdade de Educação da USP: o Manual do Estagiário e a portaria de estágio. Estas duas realizações fazem parte de um mesmo processo de sistematização da estrutura, do funcionamento, das normas e dos procedimentos relativos ao estágio curricular obrigatório na unidade. Nesse processo, o presente trabalho também tece considerações sobre a importância do referido manual e da portaria para uma faculdade com enorme quantidade de estagiários e grande diversidade de propostas e práticas de estágio.
Metodologias Ativas e Tecnologia na Educação Odontológica: Avaliação como Ferramenta de Aprendizagem
Authors: Skelton-Macedo Mary Caroline , Antoniazzi João Humberto , Machado Manoel Eduardo Lima , Gavini Giulio
Published: July 2017

A eficácia do processo de ensino-aprendizagem deve ser destacada na avaliação discente. As mudanças ocorridas no âmbito da comunicação e a aplicação de novas tecnologias na educação exigem estudo continuado para que se estabeleçam novas estratégias para o processo como um todo. A estratégia aqui apresentada foi pautada nesses preceitos, com o objetivo de promover entre os alunos de graduação a avaliação de seus próprios desempenhos, para que se comunicassem e trocassem informações com professores, colegas e/ou as buscassem conteúdos nos livros e na internet, atendendo à andragogia. A motivação foi observar suas reações, desempenho e observações pessoais. A avaliação de uma turma de 53 alunos do curso de Odontologia noturno da FOUSP foi realizada a distância e permaneceu aberta durante uma semana, permitindo que cada um a preenchesse e a corrigisse até duas vezes antes de ela ser encerrada. Todos foram estimulados a buscar ajuda de colegas, professores, bem como recorrer a pesquisas na biblioteca e na internet. Os alunos que alcançassem nota inferior a 6,00 fariam a correção junto ao professor. Todos foram submetidos a um questionário para averiguar como estudaram e o que consideraram a respeito da estratégia. A nota média da turma foi 6,21; a máxima, 9,17; e a mínima, 2,50. Concluiu-se que houve troca de informações com colegas e professores e também a consulta de diferentes materiais. O que se considerava “cola” passou a constituir um instrumento de aprendizagem. A estratégia é viável e torna o estudante corresponsável por sua aprendizagem e desempenho.
Atualização das disciplinas de comunicação gráfica para engenharia seguindo a abordagem Project Based Learning (PBL)
Authors: Ferreira Sérgio Leal , Santos Eduardo Toledo , Yee Cheng Liang , Leite Brenda Chaves Coelho , Vásquez Alvarez Elsa , Corrêa Fabiano Rogério , Kurokawa Fernando Akira , Petreche João Roberto Diego , Cardoso Luiz Reynaldo De Azevedo
Published: July 2017

As disciplinas de Comunicação Gráfica para Engenharia da Escola Politécnica da Universidade de São Paulo têm sofrido constantes reformulações ao longo dos anos. Adotar a abordagem do Aprendizado Baseado em Projetos (Project-based Learning – PBL) pareceu adequar-se perfeitamente às necessidades e aos objetivos de tais disciplinas e tornou-se uma meta dos últimos oferecimentos destas. Uma das principais metas foi proporcionar um maior contato, e consequente motivação, dos alunos do primeiro ano com assuntos mais relacionados à engenharia, como o projeto e a fabricação de um objeto que cumpre uma tarefa. Tais alunos ingressaram em um ambiente novo, e a maioria das disciplinas dos primeiros anos não contempla conteúdos mais diretamente ligados à engenharia. O presente relato apresenta os dados e as circunstâncias mais representativas dessa experiência e pretende ser um estímulo e uma ajuda a outras disciplinas que pretendam caminhar por trilhas semelhantes.
Aortic Arch Pulse Wave Velocity Assessed by Magnetic Resonance Imaging as a Predictor of Incident Cardiovascular Events
Authors: Ohyama Yoshiaki , Ambale-Venkatesh Bharath , Noda Chikara , Kim Jang-Young , Tanami Yutaka , Teixido-Tura Gisela , Chugh Atul R. , Redheuil Alban , Liu Chia-Ying , Wu Colin O. , Hundley W. Gregory , Bluemke David A. , Guallar Eliseo , Lima Joao A.C.
Published: July 2017

The predictive value of aortic arch pulse wave velocity (PWV) assessed by magnetic resonance imaging for cardiovascular disease (CVD) events has not been fully established. The aim of the present study was to evaluate the association of arch PWV with incident CVD events in MESA (Multi-Ethnic Study of Atherosclerosis). Aortic arch PWV was measured using magnetic resonance imaging at baseline in 3527 MESA participants (mean age, 62±10 years at baseline; 47% men) free of overt CVD. Cox regression was used to evaluate the risk of incident CVD (coronary heart disease, stroke, transient ischemic attack, or heart failure) in relation to arch PWV adjusted for age, sex, race, and CVD risk factors. The median value of arch PWV was 7.4 m/s (interquartile range, 5.6–10.2). There was significant interaction between arch PWV and age for outcomes, so analysis was stratified by age categories (45–54 and >54 years). There were 456 CVD events during the 10-year follow-up. Forty-five to 54-year-old participants had significant association of arch PWV with incident CVD independent of CVD risk factors (hazard ratio, 1.44; 95% confidence interval, 1.07–1.95;
P
=0.018; per 1-SD increase for logarithmically transformed PWV), whereas >54-year group did not (
P
=0.93). Aortic arch PWV assessed by magnetic resonance imaging is a significant predictor of CVD events among middle-aged (45–54 years old) individuals, whereas arch PWV is not associated with CVD among an elderly in a large multiethnic population.
Outcomes and Prognostic Impact of Prophylactic Oral Anticoagulation in Anterior ST‐Segment Elevation Myocardial Infarction Patients With Left Ventricular Dysfunction
Authors: Shavadia Jay S. , Youngson Erik , Bainey Kevin R. , Bakal Jeffrey , Welsh Robert C.
Published: July 2017

Background

The contemporary role of prophylactic anticoagulation following extensive anterior wall
ST
‐segment myocardial infarction (
STEMI
) is unclear.

Methods and Results

We evaluated anterior
STEMI
patients with left ventricle dysfunction (left ventricular ejection fraction ≤40%) (“high risk”), categorized by prophylactic warfarin use, within a regional
STEMI
. Patients with pre‐existing atrial fibrillation were excluded. The primary outcome was an adjusted (for Global Registry of Acute Coronary Events risk score) 1‐year composite of recurrent ischemia, stroke/transient ischemic attack/systemic embolism, or all‐cause death. Of the 2032
STEMI
admissions, 436 (21.5%) were high risk. After excluding 19 (4.4%) patients with definite left ventricle thrombus and 21 (4.8%) in‐hospital deaths (2 had left ventricle thrombus), prophylactic warfarin was utilized in 236/398 (59.3%) high‐risk survivors. Prescriptions were comparable across sex, but recipients were on average younger (58.5 years versus 64.0 years,
P
<0.001) and lower risk (Global Registry of Acute Coronary Events risk: 163 versus 181,
P
<0.001). No association on the adjusted ischemic composite (23.3% versus 25.3%, odds ratio 0.96, 95%
CI
0.60–1.55) or thromboembolic events (2.1% versus 1.2%, odds ratio 1.99, 95%
CI
0.38–10.51) was observed, but reduced 1‐year all‐cause mortality was noted (2.5% versus 8.6%, odds ratio 0.30, 95%
CI
0.11–0.81); numerically higher major bleeding was observed at 1 year (2.5% versus 1.2%, odds ratio 2.17, 95%
CI
0.43–10.96).

Conclusions

A high utilization of prophylactic warfarin occurs in anterior
STEMI
patients with left ventricle dysfunction, yet appears to provide no additional benefit on the ischemic composite. The association with lower all‐cause mortality, but higher bleeding, calls for an improved understanding of its role in high‐risk
STEMI
.
Taraxacum sect. Orientalia (Compositae-Crepidinae) and the West Himalayan dandelions: A new interpretation
Authors: KIRSCHNER JAN , ŠTĚPÁNEK JAN , ZEISEK VOJTĚCH
Published: July 2017

The Taraxacum flora of the West Himalaya represents one of the dandelion diversity hotspots, with at least 17 sections and about 150 known species. A number of names published from that region were referred to T. sect. Orientalia Handel-Mazzetti in the literature. All these names are revised and newly interpreted, with emphasis on plants erroneously determined as T. stenolepium. The revision is based on both older herbarium collections and a new material from expeditions of the late L. Klimeš. A new section, T. sect. Squamulosa, is recognized. An nrDNA ITS sequence analysis including the only sexual member of T. section Squamulosa and the other sexual taxa known in Taraxacum shows a separate position of T. sect. Squamulosa. The new section is compared with sections Primigenia, Coronata and Orientalia. Amended descriptions, range extensions and new interpretations are presented for another seven species previously mistakenly referred to T. sect. Orientalia. The true T. sect. Orientalia is analysed and briefly characterized; it is shown to be absent from the West Himalaya.
Dysaphis (Dysaphis) kadyrovi sp. nov.—a new aphid species (Hemiptera: Aphididae) from Tajikistan
Authors: DEPA ŁUKASZ , KANTURSKI MARIUSZ , TASZAKOWSKI ARTUR , WALCZAK MARCIN , TASZAKOWSKI ARTUR , WALCZAK MARCIN , BUGAJ-NAWROCKA AGNIESZKA , WIECZOREK KARINA
Published: July 2017

Dysaphis (Dysaphis) kadyrovi Depa & Kanturski sp. nov., a new aphid species associated with an endemic plant species Anacantha darwasica (C. Winkl.) Soják (Asteraceae) is described and figured from specimens collected in Tajikistan. Taxonomic comments on the morphological resemblance of the new species to closely related Dysaphis (D.) pseudomolli Narzikulov is provided. In view of the finding that the new species shares identical COI sequence with that reported for the morphologically distinct Dysaphis (Dysaphis) lappae lappae (Koch), the reliability of barcoding and molecular data is discussed.
A new South American species of Palaeophileurus Kolbe (Coleoptera: Scarabaeidae: Dynastinae: Phileurini)
Authors: MORENO JHON CÉSAR NEITA , RATCLIFFE BRETT C.
Published: July 2017

A new species of the Palaeophileurus Kolbe (Coleoptera: Scarabaeidae: Dynastinae: Phileurini) is described from Colombia, Ecuador, and Guyana along with supporting illustrations and a diagnosis. A checklist of Palaeophileurus species is included with a new country record for Colombia of Palaeophileurus proximus Dechambre.
A new species of the genus Neolycaena de Nicéville, 1890 from Kyrgyzstan (Lepidoptera, Lycaenidae)
Authors: KORB STANISLAV K.
Published: July 2017

A new species from the genus Neolycaena de Nicéville, 1890 (N. ittohtoriti sp. n.) is described from the mountains of Kyrgyzstan near Bishkek. The new species differs from the closely related N. tengstroemi (Erschoff, 1874) and N. carbonaria (Groum-Grshimaïlo, 1890) in morphology of the female genitalia, in some features of the wing pattern and in the COI gene sequence.
What Does it Mean to Say a Test is Biased?
Authors: Green Donald Ross
Published: July 2017

A biased test is generally understood to be a test that produces results that are systematically unfair to some group. For this to happen, the test must ordinarily measure variables for that group at least partly distinct from those it measures for other people in the population. There are two elements in this proposition: on the one hand, there is a matter of fairness, and, on the other hand, there is a matter of measuring different things for different groups. Although the two are logically related, they are not identical in all instances. That is, a test must usually measure different things for different groups to be unfair, but it is possible to have a test that measures different things for different groups and yet does not produce unfair results because of the way it is used.
Foreign Direct Investment Inflows to India
Authors: Sidhu H.S. , Dhingra Neerja
Published: July 2017

India, without exception, as in case of other developing countries, is eager to prompt its economic growth which compels it to accept and seek assistance of foreign direct investment (FDI). At present, it accounts for 1.25 per cent share of global FDI inflows, 7.18 per cent of Asian inflows and garners more than two third share of FDI inflows to the developing South Asia. Present study traces the history of FDI in India and reveals that actually FDI in India is an evolution since mid-eighteenth century and is an outcome of international and domestic dynamisms. It is not merely a phenomenon of post Independence or post liberalization period. Present study is an effort to examine the growth of FDI inflows to India and some selected representative countries of the developing Asia, through the computation of compound annual growth rates by fitting an exponential function estimated by ordinary least square method. It is detected that during the last three decades, the growth of FDI inflows remained highest in case of India followed by UAE, Turkey and China. What will happen in future is the function of what happened in the past. Believing this, the study has generated the forecasts of FDI inflows to the representative countries of Asia for the period 2009 to 2020, by using Double Exponential Smoothing Model. The adequacy of the model is tested by computing autocorrelation coefficients and Ljung-Box Q statistics. The study revealed that in the ensuing decade, out of all the countries of developing Asia, Saudi Arabia is expected to grow at the fastest pace as far as FDI inflows are concerned. In near future, although the magnitude of FDI inflows may remain highest in case of China but India is expected to leap forward swiftly and attract more than one seventh share of aggregate anticipated inflows to the developing Asia.
Gains from India-Korea CEPA
Authors: Sahoo Pravakar , Kumar Rai Durgesh , Kumar Rajiv
Published: July 2017

The signing of India-Korea CEPA on 7 August 2009 is considered a welcome step in India's “Look Fast” policy. It is a significant move in fostering a regional integration by both sides. The increase in merchandise bilateral trade has largely been attributed to changing demand structure and comparative advantages of both the economies in complementary sectors. The successful completion of CEPA is timely and supported by increasing trade complementarity index (TCI) which shows both the countries' trade has gradually become more compatible over the period. Further, the intra-industry trade (IIT) analysis shows that IIT is low in top traded product groups and high in some products where trading is low thereby offering huge opportunity for intra-industry trade when sector specific barriers will be removed after CEPA enforcement. The substantial reduction of both tariffs and non-tariff barriers in a phased manner would take India-Korea relations to a higher level and also India's presence in East Asia. Apart from increase in trade, the two positive results expected due to the agreement are increase in Korean FDI inflows into Indian manufacturing and outflow of professionals from India to Korea.
Facilitating Self-Evaluation in Task-Oriented Group Learning
Authors: Tilton John R. , Jensen Barry T.
Published: July 2017

The effects of knowledge of results on discussions directed toward improving performance in work groups are examined for complex man-machine relationships.
The Evolution of the Systems Approach in Human Factors Engineering: From the Viewpoint of an Engineering Psychologist
Authors: Christensen Julien M.
Published: July 2017

The history of human factors engineering is traced from the beginnings of mankind through the several phases of the industrial revolution. An attempt is made to show that as man's interactions with other elements (organic and inorganic) increase, so increases the need for the development of a body of principles of specific and general utility in the conceptualization, design, manufacture, test, and use of modern systems. In addition, the recent history of human factors discloses a progression in application from retrofit and detailed design to the current stage of sophistication, which considers men and machines in support of conceptual design. This progression in human factors neatly parallels the need for a more nearly universal theory of systems that is capable of handling the inputs from all the sciences and engineering disciplines that contribute to the establishment and operation of modern complex systems.