bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Susceptibility of Asphalt Binders to Rutting through MSCR Test
Authors: Chang Rong , Sha Aimin , Zhao Pinxue , Huang Songchang , Qi Cong
Published: December 2021

Using modified asphalt binder is one of the most effective methods to solve the rutting problem of asphalt pavement, but the traditional G∗/sin  δ parameter is not enough to characterize the rutting resistance of modified asphalt in field use. In order to accurately evaluate the high temperature performance of asphalt and establish the relationship between the rutting resistance of binder and mixture, two kinds of matrix asphalt and three kinds of modified asphalt were selected for DSR and MSCR tests. G∗/sin  δ, nonrecoverable creep compliance Jnr, recovery rate R, and other parameters were used to characterize the permanent deformation resistance of the binder, and the correlation between these parameters and the results of rutting test was analyzed. The results show that Jnr3.2 can accurately characterize the permanent deformation resistance of asphalt, while the stress sensitivity index Jnrdiff is not applicable to all types of modified asphalt. In contrast, Jnrslope can better reflect the stress sensitivity of asphalt, and Jnrslope is significantly correlated with the results of rutting test.
Efficacy of Tocilizumab in COVID‐19: Single‐Center Experience
Authors: Kaya Safak , Kavak Seyhmus
Published: December 2021

Background. Cytokine release syndrome can be observed during the course of COVID‐19. Tocilizumab is used for treating this highly fatal syndrome. We think that the starting time of tocilizumab is important. In this article, we aimed to discuss the efficacy of tocilizumab and to review the necessity of starting it in the early period and the laboratory values that guide us in determining the time of this early period. Methods. This retrospective study includes a total of 308 patients with a diagnosis of COVID‐19 who were treated with tocilizumab, who were hospitalized in the University of Health Sciences, Gazi Yaşargil Training and Research Hospital between July 2020 and December 2020. The data of the patients were recorded on the day of hospitalization, the day of taking tocilizumab (day 0), and the 1st day, 3rd day, 7th day, and 14th day after taking tocilizumab. Data included age, gender, underlying diseases, where the patient was followed, duration of symptoms before admission to the hospital, duration of oxygen demand before tocilizumab, fever, saturation, and laboratory values. Patients were divided into the mortality group (group 1) and the survival group (group 2), and all data were compared. Results. The study consisted of 308 COVID‐19 patients divided into two groups: the mortality group (group 1, n = 135) and the survival group (group 2, n = 173). The median age of the patients was 60 (min–max: 50‐70) years, 75.3% (n = 232) were male, and 56.8% had at least one comorbidity. While 88.9% of group 1 was in the intensive care unit, 26.6% of group 2 received tocilizumab while in the intensive care unit, and there was a statistically significant difference. Median SpO2 values and lymphocyte counts were significantly lower in group 1 than in group 2, both on the day of hospitalization and on the day of the first dose of tocilizumab treatment (p < 0.001 for both). C‐reactive protein, d‐dimer, and alanine aminotransferase values were higher in the mortal group on the first day of hospitalization, and this was significant (p = 0.021, p = 0.001, and p = 0.036, respectively). In our study, d‐dimer was 766.5 ng/mL in the survivor group and 988.5 ng/mL in the mortal group. In our patient group, the mean lymphocyte count was 700 × 103/mm3 in the group that survived the first day of TCZ and 500 × 103/mm3 in the mortal group. In addition, the CRP value was 135.5 mg/L in the survivor group and 169 mg/L in the mortal group. There was no difference between ferritin values. Conclusions. Tocilizumab is still among the COVID‐19 treatment options and appears to be effective. But the start time is important. In order to increase its effectiveness, it may be important to know a cut‐off value of the laboratory findings required for the diagnosis of cytokine release syndrome. Further studies are needed for this.
Construction of Credibility Model for Evaluating the Effectiveness of Ecological Civilization Education
Authors: Yu Lushan
Published: December 2021

The concept of green development as a rational grasp of the relationship between man and nature is not only an important embodiment of the line of thought of seeking truth from facts and advancing with the times but also a concrete application of Marxist materialistic dialectics combined with the current situation of China’s development. Ecological consciousness is a value orientation that reflects the harmonious development of man and nature as a worldview and methodology to explore and reflect on the ecological and environmental problems of the current society. College students are an important force in promoting China’s development in the future, and cultivating their good ecological consciousness with the concept of green development as a guide for action is of great significance at both the theoretical level and the practical level. Based on the review of online reviews, this study proposes that the content of positive reviews can be classified into praiseworthy reviews. In order to verify the objectivity of the content dimensions of the three types of positive comments, this study selected 1,800 positive comments as the research sample using stratified random sampling and conducted a content analysis of the comment samples one by one using the NET method. The content analysis results showed that praiseworthy comments appeared in almost all of the samples, constructive comments appeared in 23% of the samples, and prosocial comments appeared in only 14% of the sample. The results of the content analysis show that it is necessary to identify the dimensions of positive online comments because the single-dimensional constructs cannot effectively present the multidimensional information content contained in positive comments. By studying the geometric modeling method in soft tissue modeling technology, we propose covering the surface model on the outer surface of the physical model and using the tetrahedral mesh as the support skeleton of the physical model. Through the purification of the initial items and secondary testing, a scale with good reliability and validity for measuring the three constructs of praiseworthy, constructive, and prosocial comments was finally obtained.
Effect of Massive Transfusion Protocol on Coagulation Function in Elderly Patients with Multiple Injuries
Authors: Li Danjie , Zhang Wenfeng , Wei Xiaoqiang
Published: December 2021

Objective. To evaluate the effect of massive transfusion protocol on coagulation function in elderly patients with multiple injuries. Methods. In this retrospective cohort study, clinical data were collected from a total of 94 elderly patients with multiple injuries, including 44 cases who received routine transfusion protocol (control group) and 50 cases who concurrently received massive transfusion protocol in our hospital (research group). The changes in platelet parameters, coagulation function, and organ dysfunction scores at admission and 24 h after transfusion were compared between the two groups. The 24-hour plasma and red blood cell transfusion volume, length of stay, complications, and mortality of the two groups were analyzed statistically. Results. Twenty-four hours after blood transfusion, the hematocrit, platelets, and hemoglobin in the research group were higher than those in the control group, while the activated partial thromboplastin time, prothrombin time, thrombin time, fibrinogen, and scores of Marshall scoring system and Sequential Organ Failure Assessment were lower than those in the control group (

P
<
0.01

). The 24-hour plasma transfusion volume was higher, and the length of intensive care unit (ICU) stay and total length of stay were lower in the research group compared with the control group (

P
<
0.01

). No significant difference was found in the mortality rate between the research group and the control group (10.00% vs. 13.64%,

P
>
0.05

). The incidence of complications in the research group was lower than that in the control group (12.00% vs. 31.82%,

P
<
0.05

). Conclusion. Massive transfusion protocol for elderly patients with multiple injuries can improve their coagulation function and platelet parameters, alleviate organ dysfunction, shorten length of ICU stay, and decrease the incidence of complications, which is conducive to improving the prognosis of patients.
Characteristics of Adult Sepsis Patients in the Intensive Care Units in a Tertiary Hospital in Jordan: An Observational Study
Authors: Abu-Humaidan Anas H. A. , Ahmad Fatima M. , Al-Binni Maysaa’ A. , Bani Hani Amjad , Abu Abeeleh Mahmoud
Published: December 2021

Sepsis is a global health issue that is commonly encountered in the intensive care unit (ICU) and is associated with high morbidity and mortality. Available data regarding sepsis in low- and middle-income countries (LMIC) is lacking compared to higher income countries, especially using updated sepsis definitions. The lack of recent data on sepsis in Jordan prompted us to investigate the burden of sepsis among Jordanian ICU patients. We conducted a prospective cohort study at Jordan University Hospital, a tertiary teaching hospital in the capital, Amman. All adult patients admitted to the adult ICUs between June 2020 and January 2021 were included in the study. Patients’ clinical and demographic data, comorbidities, ICU length of stay (LOS), medical interventions, microbiological findings, and mortality rate were studied. Descriptive and inferential statistics were used to analyse data from patients with and without sepsis. We observed 194 ICU patients during the study period; 45 patients (23.3%) were diagnosed with sepsis using the Sepsis-3 criteria. Mortality rate and median ICU LOS in patients who had sepsis were significantly higher than those in other ICU patients (mortality rate, 57.8% vs. 6.0%,

p

value < 0.001, resp., and LOS 7 days vs. 4 days,

p

value < 0.001, resp.). Additionally, sepsis patients had a higher combined number of comorbidities (2.27 ± 1.51 vs. 1.27 ± 1.09,

p

value < 0.001). The use of mechanical ventilation, endotracheal intubation, and blood transfusions were all significantly more common among sepsis patients. A causative organism was isolated in 68.4% of sepsis patients with a prevalence of Gram-negative bacteria in 77.1% of cases. While the occurrence of sepsis in the ICU in Jordan is comparable to other regions in the world, the mortality rate of sepsis patients in the ICU remains high. Further studies from LMIC are required to reveal the true burden of sepsis globally.
[Retracted] A Novel Optimal Robotized Parking System Using Advanced Wireless Sensor Network
Authors: Manoharan Hariprasath , Teekaraman Yuvaraja , Kuppusamy Ramya , Radhakrishnan Arun
Published: December 2021

This article addresses the importance of parking system which makes the movement of moving vehicles to be unrestricted thus providing integration between hominid classification and sensing systems. If two distinct systems are combined, then all the vehicles can monitor the parking space, and they can directly move towards the destination end within short span of time. In addition for this type of establishment, rapidity of transportation vehicles is calculated with error minimization technique where all technical hitches will be avoided by sustaining the user constraints. Further, to solve the designed user constraints, a nonlinear optimization which is termed as machine learning algorithm is introduced for avoiding high loss during packet transmission technique, and percentage of efficiency is analyzed using simulated results with network simulator (NS2). Moreover, from simulated results, it is substantiated that the projected method on automatic parking of vehicles provides high efficient operation, and even cost of installation is reduced.
Treatment Effect of a Vascular-Disrupting Agent Dynamically Monitored by DWI: An Animal Experimental Study
Authors: Huang Danping , Yang Ruimeng , Zou Yong , Lin Hongmei , Xu Xiangdong , Wei Xinhua , Chang Hanzheng , Wu Liqiong , Ding Wenshuang , Tang Wenjie , Jiang Xinqing
Published: December 2021

Objective. To investigate the treatment effect of a vascular-disrupting agent, M410, using diffusion-weighted imaging in a rabbit model of hepatic VX2 tumor. Methods. 28 New Zealand white rabbit models with VX2 liver tumors were established and were randomly divided into M410 (intravenous injection of M410 at a dose of 25 mg/kg every three days) and control (intravenous injection of saline every three days) groups. Conventional and diffusion-weighted imaging (DWI) were acquired on a 3.0 T MR unit at baseline, 4 h, d 1, d 4, d 7, and d 14 posttreatment. B-value with 700 (s/mm2) was chosen during DWI examinations. Tumor volume and apparent diffusion coefficient (ADC) values of the entire tumor and solid component of the tumor at every time point were measured. Two randomly chosen rabbits from each group were sacrificed for H&E staining and CD34 immunohistochemical assessments at each time point. An independent sample t-test was used to assess differences in tumor sizes and ADC values of the entire tumor and solid component of tumors between two groups, with

P
<
0.05

considered statistically significant. Result. There was no significant difference in tumor volume between the two groups at baseline, 4 h, and d 1. With time, the tumors in the control group grew significantly faster than those in the M410 group, and the average ADC values of the M410 group were lower than those of the control group at d 1 and higher than those of the control group at d 4; as such, there were statistical differences between the two groups at these two time points but not at the other four time points. The following pathological results reflected the underlying morphological changes and vascular alterations. Conclusions. M410 performed well in inhibiting the growth of the hepatic VX2 tumor which could be noninvasively monitored by DWI metrics.
Evolutionary Dynamics of Mandatory Lane Changing for Bus Exiting
Authors: Yao Ronghan , Du Xiaojing , Qi Wenyan , Sun Li
Published: December 2021

With the development of the connected autonomous bus, the interactions between the bus and social vehicle during the mandatory lane changing for bus exiting become more diverse and complex. This research investigates the evolutionary dynamics of behavioral decision-making for the bus and social vehicle in different scenarios. The evolutionary game model for the connected autonomous bus and social vehicle is built, as do the human-driven bus and social vehicle, and the connected autonomous bus under different penetration rates and social vehicle. The results of numerical experiments reveal that the connected autonomous bus chooses to change lanes in most instances, and the strategies of the human-driven bus show conservative tendencies. Such tendencies are weakened when the connected autonomous bus and human-driven bus are mixed. As for the social vehicle in different scenarios, the strategies that balance overall traffic safety and efficiency are promoted. This research provides some references for intelligent decision-making of lane changing in urban public transportation.
Multimedia Recognition of Piano Music Based on the Hidden Markov Model
Authors: Zhu Ying
Published: December 2021

Piano performance is an art with rich artistic elements and unpredictable performance skills. It is an important carrier for playing beautiful piano sounds. The generation of musical tension and expression of piano performance is a vivid display of piano performance skills. In piano performance, we should pay attention to the cultivation and flexible application of performance skills. In order to ensure the richness and artistry of piano performance, it is fully based on the artistic characteristics of piano performance. Through in-depth analysis of the principle of the hidden Markov model, it is applied to the multimedia recognition process of piano playing music. In the process of obtaining the template, the fundamental frequency of the piano playing music differs greatly, and the piano playing music appears during the performance process. For the problem of low recognition rate, this paper proposes a multimedia recognition method for piano music. Finally, the analysis of experimental results shows that the method proposed in this paper has a 16% higher recognition rate than the traditional method, and it has a certain value in the multimedia recognition of piano music.
Synthesis of Silver and Gold Nanoparticles: Chemical and Green Synthesis Method and Its Toxicity Evaluation against Pathogenic Bacteria Using the ToxTrak Test
Authors: Tyagi Pankaj Kumar , Quispe Cristina , Herrera-Bravo Jesús , Tyagi Shruti , Barbhai Mrunal D. , Kumar Manoj , Dablool Anas S. , Alghamdi Saad , Batiha Gaber El-Saber , Sharifi-Rad Javad , Ramniwas Seema
Published: December 2021

In the current investigation, silver/gold nanoparticles (NPs) were synthesized using two methods: chemical and biological, and then characterized colloidal solutions of both NPs using UV-Vis, transmission electron microscopy (TEM) and zeta potential analyzers, X-ray powder diffraction (XRD), and energy dispersive X-ray (EDX) as well as the ToxTrak test for in vitro toxicity and antibacterial activity against Gram-positive bacteria (B. subtilis) and Gram-negative bacteria (E. coli). The plasmon peak of chemical synthesized silver NPs (CH-AgNPs) and gold NPs (CH-AuNPs) was observed at 414 and 530 nm, respectively, while the sharp plasmon peak of biological synthesized silver NPs (Bio-AgNPs) and gold NPs (Bio-AuNPs) was observed at 410 and 525 nm. Under transmission electron microscopy (TEM), the average sizes of CH-AgNPs and CH-AuNPs were 50.56 and 25.98 nm, respectively. Bio-AgNPs and Bio-AuNPs, on the other hand, had average sizes of 25.25 and 16.65 nm, respectively. The stability of NPs was also investigated using the zeta potential. The crystalline structure of AgNPs was confirmed through XRD, and EDX results confirm the element compositions. In the ToxTrak test, the toxic effect value/percentage inhibition (TEV/PI) was calculated. The results showed that CH-AgNPs have the highest TEV/PI value (85.45% for B. subtilis and 83.77% for E. coli) when compared to Bio-AgNPs (55.75% for B. subtilis and 54.42% for E. coli). CH-AuNPs, on the other hand, were 33.51% toxic to B. subtilis and 36.85% toxic to E. coli, compared to Bio-AuNPs, which were 23.36% toxic to B. subtilis and 24.46% toxic to E. coli. The antibacterial activity of Ag/Au NPs was tested and monitored; zone of inhibition (mm in diameter) against B. subtilis and E. coli, with the following pattern emerging: CH-AgNPs (24.80) had the highest antibacterial activity followed by Bio-AgNPs (22.80) < CH-AuNPs (10.60) < Bio-AuNPs (09.00), whereas the control sample (tetracycline antibiotic) revealed a 25.08 mm, zone of inhabitation. Overall, Bio-AgNPs and Bio-AuNPs are the most effective pathogen-killing materials with the lowest toxicity. Our suggestion is that such materials instead of chemical synthesized NPs can be used to coat antibiotic drugs and could be a game-changer for the pharmaceutical industry in terms of effectively controlling the pathogenic bacteria.
MicroRNA-137-3p Improves Nonalcoholic Fatty Liver Disease through Activating AMPKα
Authors: Yu Yuanjie , He Chunping , Tan Shiyun , Huang Mengjun , Guo Yitian , Li Ming , Zhang Qian
Published: December 2021

Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide and can develop to nonalcoholic steatohepatitis and later hepatic cirrhosis with a high prevalence to hepatocellular carcinoma. Oxidative stress and chronic hepatic inflammation are implicated in the pathogenesis of NAFLD. MicroRNA-137-3p (miR-137-3p) are associated with oxidative stress and inflammation; however, its role and mechanism in NAFLD remain unclear. Mice were fed with a high-fat diet (HFD) for 24 weeks to establish the NAFLD model. To overexpress or suppress hepatic miR-137-3p expression, mice were intraperitoneally injected with the agomir, antagomir, or respective controls of miR-137-3p at a dose of 100 mg/kg weekly for 6 consecutive weeks before the mice were sacrificed. To validate the involvement of AMP-activated protein kinase alpha (AMPKα) or cAMP-specific phosphodiesterase 4D (PDE4D), HFD mice were intraperitoneally injected with 20 mg/kg compound C or 0.5 mg/kg rolipram every other day for 8 consecutive weeks before the mice were sacrificed. Hepatic miR-137-3p expression was significantly decreased in mice upon HFD stimulation. miR-137-3p agomir alleviated, while miR-137-3p antagomir facilitated HFD-induced oxidative stress, inflammation, and hepatic dysfunction in mice. Mechanistically, we revealed that miR-137-3p is directly bound to the 3

′

-untranslated region of PDE4D and subsequently increased hepatic cAMP level and protein kinase A activity, thereby activating the downstream AMPKα pathway. In summary, miR-137-3p improves NAFLD through activating AMPKα and it is a promising therapeutic candidate to treat NAFLD.
Knowledge, Attitude, and Practices of Unused Medications Disposal among Patients Visiting Public Health Centers in Gondar Town, Ethiopia: A Cross-Sectional Study
Authors: Woldeyohanins Alem Endeshaw , Adugna Meaza , Mihret Tigabu , Kifle Zemene Demelash
Published: December 2021

Background. The improvement of healthcare systems has brought the subsequent increase in people access to medications. The consumers are not able to use all the dispensed medications because of various reasons. The improper disposal of these unused medicines has led to environmental contamination to an alarming extent. Therefore, the study was conducted to assess the knowledge, attitude, and practice of unused medications disposal among patients visiting public health centers in Gondar town, Ethiopia. Methods. A descriptive cross-sectional study was conducted among 404 patients visiting public health centers in Gondar town, Ethiopia, from August to September 2021, by using standardized and a locally translated semistructured questionnaire. The data were entered and analyzed by using the SPSS version of 21.0. The variable of interest was described in the form of statements and tables. Result. Out of 404 respondents included in the study, 221 (54.7%) of them were female. More than half (226 (55.9%)) of the respondents had unused medicine at home. The common methods of disposal practice were throwing into a household garbage (150 (31.4%)), followed by flushed into toilet/sinks (88 (21.8%)). More than half (286 (70.8%)) of the respondents knew about medication waste and 239 (59.2%) of them checked their medication expiry date. More than half (215 (53.5%)) of the participants strongly agreed that unused medicine can cause potential risk at home and 279 (69.1%) of study participants strongly agreed that children are more vulnerable to the potential risk of unused medicine at home. Conclusion. There was a high practice of keeping medication at home, and most disposal approach indicated by the participants was not recommended methods. Awareness about the proper disposal of unused medicines among the public should be created. Guidelines on safe disposal are required, and an organized method of collecting unused and expired pharmaceuticals needs to be introduced.
CircRNA FAT1 Regulates Osteoblastic Differentiation of Periodontal Ligament Stem Cells via miR-4781-3p/SMAD5 Pathway
Authors: Ye Yu , Ke Yue , Liu Liu , Xiao Tong , Yu Jinhua
Published: December 2021

The ability of human periodontal ligament stem cells (PDLSCs) to differentiate into osteoblasts is significant in periodontal regeneration tissue engineering. In this study, we explored the role and mechanism of circRNA FAT1 (circFAT1) in the osteogenic differentiation of human PDLSCs. The proliferation capacity of PDLSCs was evaluated by EdU and CCK-8 assay. The abilities of circFAT1 and miR-4781-3p in regulating PDLSC differentiation were analyzed by western blot, reverse transcription-polymerase chain reaction (RT-PCR), alkaline phosphatase (ALP), and Alizarin red staining (ARS). A nucleocytoplasmic separation experiment was utilized for circFAT1 localization. A dual-luciferase reporter assay confirmed the binding relationship between miR-4781-3p and circFAT1. It was showed that circFAT1 does not affect the proliferation of PDLSCs. The osteogenic differentiation of PDLSCs was benefited from circFAT1, which serves as a miRNA sponge for miR-4781-3p targeting SMAD5. Both knockdown of circFAT1 and overexpression of miR-4781-3p suppressed the osteogenic differentiation of PDLSCs. Thus, circFAT1 might be considered as a potential target of PDLSCs mediated periodontal bone regeneration.
Ionizing Radiation Upregulates Glutamine Metabolism and Induces Cell Death via Accumulation of Reactive Oxygen Species
Authors: Yang Pengfei , Luo Xiangxia , Li Jin , Zhang Tianyi , Gao Xiaoling , Hua Junrui , Li Yonghong , Ding Nan , He Jinpeng , Zhang Yanan , Wei Wenjun , Wang Jufang , Zhou Heng
Published: December 2021

Glutamine metabolism provides energy to tumor cells and also produces reactive oxygen species (ROS). Excessive accumulation of ROS can damage mitochondria and eventually lead to cell death. xCT (SLC7A11) is responsible for the synthesis of glutathione in order to neutralize ROS. In addition, mitophagy can remove damaged mitochondria to keep the cell alive. Ionizing radiation kills tumor cells by causing the accumulation of ROS, which subsequently induces nuclear DNA damage. With this in mind, we explored the mechanism of intracellular ROS accumulation induced by ionizing radiation and hypothesized new methods to enhance the effect of radiotherapy. We used MCF‐7 breast cancer cells and HCT116 colorectal cancer cells in our study. The above‐mentioned cells were irradiated with different doses of X‐rays or carbon ions. Clone formation assays were used to detect cell proliferation, enzyme‐linked immunosorbent assay (ELISA) detected ATP, and glutathione (GSH) production, while the expression of proteins was detected by Western blot and quantitative real‐time PCR analysis. The production of ROS was detected by flow cytometry, and immunofluorescence was used to track mitophagy‐related processes. Finally, BALB/C tumor‐bearing nude mice were irradiated with X‐rays in order to further explore the protein expression found in tumors with the use of immunohistochemistry. Ionizing radiation increased the protein expressions of ASCT2, GLS, and GLUD in order to upregulate the glutamine metabolic flux in tumor cells. This caused an increase in ATP secretion. Meanwhile, ionizing radiation inhibited the expression of the xCT (SLC7A11) protein and reduced the generation of glutathione, leading to excessive accumulation of intracellular ROS. The mitophagy inhibitor, or knockdown Parkin gene, is able to enhance the ionizing radiation‐induced ROS production and increase nucleus DNA damage. This combined treatment can significantly improve the killing effect of radiation on tumor cells. We concluded that ionizing radiation could upregulate the glutamine metabolic flux and enhance ROS accumulation in mitochondria. Ionizing radiation also decreased the SLC7A11 expression, resulting in reduced GSH generation. Therefore, inhibition of mitophagy can increase ionizing radiation‐induced cell death.
Understanding Population Dynamics in Multi- and Many-Objective Evolutionary Algorithms for High-Resolution Approximations
Authors: Monzón Maldonado Hugo , Aguirre Hernán , Verel Sébastien , Liefooghe Arnaud , Derbel Bilel , Tanaka Kiyoshi
Published: December 2021

Achieving a high-resolution approximation and hitting the Pareto optimal set with some if not all members of the population is the goal for multi- and many-objective optimization problems, and more so in real-world applications where there is also the desire to extract knowledge about the problem from this set. The task requires not only to reach the Pareto optimal set but also to be able to continue discovering new solutions, even if the population is filled with them. Particularly in many-objective problems where the population may not be able to accommodate the full Pareto optimal set. In this work, our goal is to investigate some tools to understand the behavior of algorithms once they converge and how their population size and particularities of their selection mechanism aid or hinder their ability to keep finding optimal solutions. Through the use of features that look into the population composition during the search process, we will look into the algorithm’s behavior and dynamics and extract some insights. Features are defined in terms of dominance status, membership to the Pareto optimal set, recentness of discovery, and replacement of optimal solutions. Complementing the study with features, we also look at the approximation through the accumulated number of Pareto optimal solutions found and its relationship to a common metric, the hypervolume. To generate the data for analysis, the chosen problem is MNK-landscapes with settings that make it easy to converge, enumerable for instances with 3 to 6 objectives. Studied algorithms were selected from representative multi- and many-objective optimization approaches such as Pareto dominance, relaxation of Pareto dominance, indicator-based, and decomposition.
Prognostic Significance of the Combined Score of Plasma Fibrinogen and Neutrophil-Lymphocyte Ratio in Patients with Spontaneous Intracerebral Hemorrhage
Authors: Yang Wanchun , Yuan Yunbo , Li Junhong , Shuai Yuli , Liao Xiang , Yu Zhiyuan , Li Hao , Zheng Jun
Published: December 2021

Background. The combination of plasma fibrinogen and neutrophil to lymphocyte ratio (F-NLR) score is a novel inflammatory marker constituted by peripheral blood fibrinogen concentration and neutrophil to lymphocyte ratio. In the current study, we aim to explore the relationship between admission F-NLR score and intracerebral hemorrhage (ICH) and assess its prognostic predictive ability in ICH patients. Methods. The original cohort was consecutively recruited from August 2014 to September 2017, and the validation cohort was consecutively recruited between October 2018 and March 2020. The primary outcomes were 3-month functional outcome and 1-month mortality. All statistical analyses were performed using SPSS and R software. Results. A total of 431 and 251 ICH patients were included in original cohort and validation cohort, respectively. In the original cohort, F-NLR score could independently predict the 3-month functional outcome (adjusted OR 2.013, 95% CI 1.316-3.078,

p
=
0.001

) and 1-month mortality (adjusted OR 3.036, 95% CI 1.965-4.693,

p
<
0.001

). Receiver operation characteristic (ROC) analyses and predictive model comparison indicated that F-NLR score had a stronger predictive ability in the 3-month outcome and 1-month mortality. Validation cohort verified the results. Conclusion. F-NLR score was an independent indicator for both the 3-month functional outcome and 1-month mortality, and its prognostic predictive ability was superior to fibrinogen and NLR in both the original and the validation cohort.
[Retracted] Effects of Attentional Withdrawal on Chinese Disabled Biathletes’ Shooting Performance
Authors: Li Jin , Li Sihua
Published: December 2021

Under two situations of static empty gun preview and simulated competition, the validity of self‐suggestion language “preloading compaction,” which suggests attentional withdrawal, was verified, respectively. Methods. The experiments in the two parts were designed in a single factor group. The participants (Chinese disabled biathletes) fired 20 times (4 groups in total, 5 times in each group) both in pretest and posttest, and they used self‐suggestion before each group of firing in posttest. Optoelectronic shooting device based on wireless laser transceiver technology was selected to collect the shooting technical indicators, scores, and other information. The operation evaluation form reflected the subjective feelings of the participants, and the heart rate was measured by the chest band. Results. By the method of big data analysis, under the condition of static empty gun preview, the results showed that there was an extremely significant difference between shooting score and quality of triggering. All the marks on the operation evaluation form improved after the intervention. In the mock competition situation, shooting score has highly significant differences with quality of triggering and relative triggering value and significant difference with aiming ability. The marks of the operation evaluation form have been improved; the heart rate of firing all decreased in different degrees. Conclusions. The attentional withdrawal has positive effects on the shooting scores, technical indicators of optoelectronic shooting device, subjective feelings, and heart rate of disabled biathletes under the two conditions. TIRE (the timing of firing) is the most sensitive indicator and can be used as the focus of future training and scientific research.
A Clinical and Radiographic Evaluation of Zirconia Dental Implants: 10-Year Follow-Up
Authors: Borgonovo Andrea Enrico , Ferrario Susanna , Maiorana Carlo , Vavassori Virna , Censi Rachele , Re Dino
Published: December 2021

Purpose. The aim is to evaluate the survival and success rates, as well as the marginal bone loss (MBL) and periodontal indexes, of zirconia implants with 10-year follow-up. Materials and Methods. 10 patients were selected and 26 one-piece zirconia implants were used for the rehabilitation of single tooth or partially edentulous ridge. After 10 years, a clinical-radiographic evaluation was performed in order to estimate peri-implant tissue health and marginal bone loss. Results. The survival and success rates were 100%. The average marginal bone loss from baseline to 120 months after surgery was 0.92 ± 0.97 mm. Conclusion. One-piece zirconia dental implants are characterised by high biocompatibility, low plaque adhesion, and absence of microgap that can be related to the clinical success of these implants.
Infection Risk Prediction Model for COVID-19 Based on an Analysis of the Settlement of Particles Generated during Dental Procedures in Dental Clinics
Authors: Baldion Paula Alejandra , Rodríguez Henry Oliveros , Guerrero Camilo Alejandro , Cruz Alberto Carlos , Betancourt Diego Enrique
Published: December 2021

Background. The health emergency declaration owing to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has drawn attention toward nosocomial transmission. The transmission of the disease varies depending on the environmental conditions. Saliva is a recognized SARS-CoV-2 reservoir in infected individuals. Therefore, exposure to fluids during dental procedures leads to a high risk of contagion. Objective. This study aimed to develop an infection risk prediction model for COVID-19 based on an analysis of the settlement of the aerosolized particles generated during dental procedures. Materials and Methods. The settlement of aerosolized particles during dental aerosol-generating procedures (AGPs) performed on phantoms was evaluated using colored saliva. The gravity-deposited particles were registered using a filter paper within the perimeter of the phantom head, and the settled particles were recorded in standardized photographs. Digital images were processed to analyze the stained area. A logistic regression model was built with the variables ventilation, distance from the mouth, instrument used, area of the mouth treated, and location within the perimeter area. Results. The largest percentage of the areas stained by settled particles ranged from 1 to 5 µm. The maximum settlement range from the mouth of the phantom head was 320 cm, with a high-risk cutoff distance of 78 cm. Ventilation, distance, instrument used, area of the mouth being treated, and location within the perimeter showed association with the amount of settled particles. These variables were used for constructing a scale to determine the risk of exposure to settled particles in dentistry within an infection risk prediction model. Conclusion. The greatest risk of particle settlement occurs at a distance up to 78 cm from the phantom mouth, with inadequate ventilation, and when working with a high-speed handpiece. The majority of the settled particles generated during the AGPs presented stained areas ranging from 1 to 5 µm. This model was useful for predicting the risk of exposure to COVID-19 in dental practice.
Techno-Pedagogical Skills for 21st Century Digital Classrooms: An Extensive Literature Review
Authors: Asad Muhammad Mujtaba , Aftab Kanwal , Sherwani Fahad , Churi Prathamesh , Moreno-Guerrero Antonio-José , Pourshahian Bahar
Published: December 2021

Techno-pedagogical ability is a way and reasonable value education available to everyone. Indeed, although in the past it has been found that there are many benefits to using innovation in the classroom environment, there are still obstacles or experiences related to the use of innovation. The literature review was utilized to gather and choose the papers for this research. This article investigates the techno-pedagogical skills requirements of the science and art teachers of the Sukkur State Government College. In this paper, literature is collected from different real sites, such as Google, Google Scholar, Science Direct (Elsevier), Sage, Springer, Emerald, Taylor & Francis, and Eric databases. Ten themes emerged from the literature to analyze the techno-pedagogical skills of science and art educators and provide suggestions and solutions for improving educational institutions. Quantitative, qualitative, and mixed research papers are all included in this study. This research also identified the knowledge gap and methodological and implication gap in this research article as per the need for 21st Century Digital Classrooms. The results show that there is no significant difference in techno-pedagogical skills between science teachers and art teachers who use technology in teaching. This is because of the epidemic. Talking about the current scourge, COVID-19 has transformed traditional courses into digitization through ICT integration. Information and Communication Technology (ICT) is seen as a tool that can help schools adapt to the transition from industry to information. It is also considered as a tool to provide, support, and strengthen educational reforms in accordance with the educational needs of the information society.
Dynamics of Mosquito Population Models with Spatial Diffusion
Authors: Traoré Urbain
Published: December 2021

In this paper, we study some reaction-diffusion models of interactive dynamics of the wild and sterile mosquitoes. The well-posedness of the concerned model is proved. The stability of the steady states is discussed. Numerical simulations are presented to illustrate our theoretical results.
Assessment of Age at the Stages of the Eruption of Third Molar Teeth among the People of North‐Eastern India
Authors: Putul Mahanta , Konwar Ranjumoni , Dutta Malamoni , Basumatary Bharati , Rajbongshi Madhab Chandra , Thakuria Kahua Das , Sarma Bitumoni
Published: December 2021

Background and Objectives. In the biological age determination of a person’s teeth at adolescence, the third molar (M3) or wisdom tooth development is considered a dependable method used over the years. The present research intended to evaluate the age from the eruption status of M3 and analyze and equivalence with a different quadrant of the jaws. Methods. A cross‐sectional descriptive and analytical study was undertaken with 1060 Assamese individuals (642 males and 418 females) aged 14–26 years and was subjected to a clinical, dental, and general physical examination from January 2014 to December 2018. The data were statistically analyzed using Microsoft Excel and the Statistical Package for the Social Sciences (SPSS) version 22. The significant differences among variables were tested using the chi‐square test and Student’s t‐test, considering a p value < 0.05 as significant. Results. The carried‐out research showed no eruption (NE) status of M3 with an overall mean (±SD) age at 17.39 (±2.273) years, although a significantly lower age among males with a mean age of 16.92 (±2.138) years (p value < 0.001) was observed. The mean age (overall) for the complete eruption (CE) was observed at 20.33 (±2.566) years, which was seen earlier in males. The mandibular M3 appears earlier compared to the maxillary M3. The third molar eruption (TME) on both left and right quadrants of the jaw was observed substantially earlier in the lower jaw, compared to the upper jaw (p value < 0.025). The earliest CE of M3 was marked at 15 years. The differences in the frequencies of TME in different chronological age groups were found significant (p value < 0.001). A significant association between gender and TME (p value < 0.045) in the current study is worth noting. Conclusion. Thus, determined by TME as a valid method, age can be used for various purposes to establish a person’s identity. Dental age estimated using third molar eruption status has a weighty association with chronological age. Thus, it should be utilized to determine the likely age of an individual.
Multipurpose Watermarking Approach for Copyright and Integrity of Steganographic Autoencoder Models
Authors: Gu Wei , Chang Ching-Chun , Bai Yu , Fan Yunyuan , Tao Liang , Li Li
Published: December 2021

With the great achievements of deep learning technology, neural network models have emerged as a new type of intellectual property. Neural network models’ design and training require considerable computational resources and time. Watermarking is a potential solution for achieving copyright protection and integrity of neural network models without excessively compromising the models’ accuracy and stability. In this work, we develop a multipurpose watermarking method for securing the copyright and integrity of a steganographic autoencoder referred to as “HiDDen.” This autoencoder model is used to hide different kinds of watermark messages in digital images. Copyright information is embedded with imperceptibly modified model parameters, and integrity is verified by embedding the Hash value generated from the model parameters. Experimental results show that the proposed multipurpose watermarking method can reliably identify copyright ownership and localize tampered parts of the model parameters. Furthermore, the accuracy and robustness of the autoencoder model are perfectly preserved.
[Retracted] Interfering with pak4 Protein Expression Affects Osteosarcoma Cell Proliferation and Migration
Authors: Fu Yuxin , Fang Lun , Yin Qipu , Wu Qi , Sui Wei , Sun Ying , Zhao Xindi , Wu Yadi , Zhou Lu
Published: December 2021

Purpose. A number of studies have discovered various roles of PAK4 in human tumors, including osteosarcoma. However, the exact role of PAK4 in osteosarcoma and its mechanism have yet to be determined. Therefore, this study focused on interrogating the PAK4 effect on the proliferation and migration ability of osteosarcoma and its underlying mechanisms. Materials and Methods. Western blot and QRT‐PCR were utilized to quantify the PAK4 relative protein and mRNA levels. To measure cellular viability and mobility, the MTT and wound‐healing assays were preferred. Results. With the adenovirus‐mediated overexpression of PAK4, the proliferation and migration of U2‐OS and MG‐63 osteosarcoma cells were stimulated. Furthermore, a liposome‐mediated knockout of PAK4 will inhibit osteosarcoma cells from proliferating. In terms of mechanism, we observed the positive correlation of PAK4 expression with expression of P21, CyclinD1, CyclinE1, CDK2, and CDK6, which drives G0/G1 to the G2/M phase transition. PAK4 can also activate Erk expression in OS cells and induce EMT. Conclusion. Interfering with PAK4 protein expression has been shown to affect osteosarcoma proliferation and migration.
Asymptomatic Scalp Carriage among Household Contacts of Children Affected by Tinea Capitis: A Prospective Study in the Metropolitan Area of Brussels, Belgium
Authors: Lecerf Pauline , Dangoisse Chantal , Van Ooteghem Aude , Vujovic Anja , Vollono Laura , Richert Bertrand
Published: December 2021

Introduction: Tinea capitis (TC) is a superficial fungal infection affecting the scalp. The existence of asymptomatic carriers (ACs) could represent a potential reservoir responsible of (re)contamination and failure of treatment. No prospective studies on ACs in household contacts of TC patients in Europe have been published to date. Objectives: The aim of this study was to assess the prevalence of ACs in a cohort of household contacts of children who were diagnosed with TC in the metropolitan area of Bruxelles, Belgium. Methods: This prospective observational study was conducted from October 2015 to April 2016 at the Dermatology Department of the University Hospitals Brugmann, Saint-Pierre, Queen Fabiola Children Hospital. Results: Ninety-nine cases of TC from 95 different family circles were included. The main infectious agent identified was Microsporum audouinii in 53 cases. The mean age of TC patients was 5.8 years. Male/female ratio was 2.8. Eighty-one household contacts of TC patients were enrolled in the study. Two cases of ACs (5%) were identified. Conclusions: M. audouinii was the most common pathogen identified. The prevalence of ACs we report is on average higher compared to other European large cities. Larger prospective studies including all close contacts of affected patients are required in order to establish guidelines regarding identification and management of ACs.
Acute Cardiac Tamponade Secondary to Cardiac Vascular-Type Pleomorphic Leiomyosarcoma: Case Report
Authors: Fernández-Ferreira Ricardo , Soberanis-piña Pamela Denisse , Conde-Flores Emilio , Arroyave-Ramírez Andrés Mauricio , Mackinney-Novelo Ileana , Motola-Kuba Daniel , Ruiz-Morales Jose Manuel , Alvarado-Luna Gabriela , Chable-Montero Fredy
Published: December 2021

Soft tissue sarcomas represent <1% of all neoplasms. Leiomyosarcomas comprise only 5–7% of cases, and only 2% of these are vascular. Vascular leiomyosarcomas are extremely rare and represent only 0.001% of all neoplasms, the venous type being up to 5 times more frequent. Arterial leiomyosarcomas most frequently affect the great vessels, being fatal in most cases. In the reported cases of arterial leiomyosarcomas, the most frequently affected site is the pulmonary artery. We present the clinical case of 2 patients (a 42-year-old woman and a 36-year-old man) with a diagnosis of arterial pleomorphic leiomyosarcoma that conditioned cardiac tamponade as the initial manifestation. As it is an exceptionally rare neoplasm and with few cases reported in the literature, it is important to identify and describe this pathology which, due to the impossibility of offering surgical treatment, represents a therapeutic challenge.