bluuebunny/crossref_metadata_2025 huggingface dataset:
Estudo comparativo entre a técnica manual e a técnica transepitelial na remoção do epitélio corneano na ceratectomia fotorrefrativa (PRK) em um hospital de referência na cidade de Cascavel/PR
Authors: Cogo Pedro Henrique , Moraes Lucas Balasso , Hallal Júnior Ramon Joaquim , Rauber Rafael
Published: July 2022

A ceratectomia fotorrefrativa (PRK) é um procedimento refrativo a laser cada vez mais usado no tratamento das ametropias. O desconforto pós-operatório ainda é uma grande desvantagem após o PRK e, portanto, analisar qual técnica proporciona menor grau de dor é de grande importância. Nesse contexto, o trabalho comparou através da aplicação da escala Wong-Baker de avaliação da dor qual a técnica, manual ou transepitelial, de remoção do epitélio corneano gerou menor grau de dor após o procedimento. Para isso, 16 pacientes (32 olhos), 8 (16 olhos) submetidos a técnica manual e 8 (16 olhos) submetidos a técnica transepitelial, preencheram a escala de dor selecionada no pós-operatório imediato, do primeiro ao quarto dia. Após apuração dos dados, que ainda levou em conta o uso de medicação para a dor (Tylex) nos 4 dias, constatou uma maior prevalência de dor nos pacientes submetidos a técnica manual em comparação com a transepitelial assim como maior uso de medicamento dor na técnica manual.
Dieta cetogênica e o tratamento do câncer
Authors: Sousa Daniel Donato de , Silva João Gabriel Toledo Pacheco , Maynard Dayanne da Costa
Published: July 2022

Diante de um aumento expressivo nas últimas décadas no caso de câncer na população mundial, evidenciou-se a necessidade de uma estratégia dietética coadjuvante ao tratamento convencional para pacientes diagnosticados com câncer, tendo como intuito obter resultados positivos na luta contra a doença. Este estudo de revisão literária teve como objetivo apresentar a dieta cetogênica (KD) como intervenção nutricional e seus mecanismos propostos contra as células oncológicas, como também caracterizar delimitações na literatura presentemente disponível. Os estudos foram selecionados pelas bases de dados BIREME, PUBMED, ScienceDirect e além de livros, sites institucionais e governamentais; utilizando-se descritores como: dieta cetogênica; doenças crônicas; câncer; tratamento do câncer e estresse oxidativo; os mesmos foram utilizados na língua inglesa. Foi proposto que, as células cancerígenas na ausência de glicose sanguínea diminuem sua proliferação e entram em um estado de estresse oxidativo, por consequência de uma dieta com alto teor em gordura e com déficit de carboidrato, assim deixando-as mais sensíveis aos tratamentos padronizados, como por exemplo, radiação e quimioterapia. Todavia, há a necessidade de maiores estudos em humanos para que se possa ter melhores resultados e conclusões a respeito dessa intervenção nutricional.
Forage productivity and morphogenesis of Mesosetum chaseae under potassium fertilization
Authors: Costa Newton de Lucena , Magalhães João Avelar , Rodrigues Braz Henrique Nunes , Santos Francisco José de Seixas
Published: July 2022

The effect of potassium levels (0, 50, 100 and 200 kg of K2O ha-1) on green dry matter (GDM) yield and morphogenetic and structural characteristics of Mesosetum chaseae (Luces) was evaluated under natural field conditions. Potassium fertilization increased significantly (P<0.05) GDM yields, absolute growth rate (AGR), number of tillers/plant, number of leaves plant-1, medium blade length, leaf area, leaf senescence rate, leaf appearance and elongation rates. Maximum GDM yields, AGR, number of tillers/plant, number of leaves/tiller, leaf area and medium blade length were obtained with the application of 167.8; 156.2; 82.7; 101.6; 101.2 and 77.5 kg of K2O ha-1, respectively. The potassium efficiency utilization was inversely proportional to the increased potassium levels.
Dor musculoesquelética em acadêmicos de um curso de Fisioterapia em Santarém, Pará, Brasil
Authors: Vinholte Paulo André da Costa , Reis João Marcos Freitas dos , Oliveira Alexandre Rodrigo Batista de , Silva Matheus Sallys Oliveira
Published: July 2022

Objetivo: Analisar o perfil dos estudantes de fisioterapia de uma instituição pública de Santarém que apresentam dores musculoesqueléticas, bem como verificar quais as dores mais frequentes e seu grau de intensidade. Metodologia: Trata-se de um estudo descritivo de corte transversal, com abordagem quantitativa, desenvolvida junto aos acadêmicos de Fisioterapia da Universidade do Estado do Pará do Campus XII/Santarém. Utilizou-se para a coleta dos dados dois instrumentos, o Questionário Nórdico de Dor e a Escala Analógica Visual de Dor (EVA) tendo 46 participantes. Pesquisa aprovada pelo comitê de ética e pesquisa da Universidade do Estado do Pará sob o nº CAEE: 42238621.8.0000.8767. Resultados: Observou-se a maioria dos participantes são do sexo feminino e possuem média de idade de 20,7 anos, verificou-se também que dentre as dores mais prevalentes entre os acadêmicos destacou-se a lombalgia com 93,48% dos relatos, em relação a intensidade da dor notou-se que a maioria das dores elencadas são leves ou moderadas, causando desconforto, mas não os impede de realizar atividades da vida diária. Conclusão: É essencial que este tema seja tratado com mais seriedade pelas instituições de ensino, pois a formação é um momento único de aprendizado, e se o acadêmico está submetido a condições extremas impostas pela rotina corrida entre estágio e aulas teóricas, chega um momento que o organismo do universitário começará a apresentar sinais de desgaste e estresse extremo.
Perspectivas sobre o uso de ultrassom por enfermeiros no departamento de emergência: uma revisão integrativa
Authors: Menezes João Daniel de Souza , Pereira Amanda Alves , Silva Isabella Salvador e , Chiminez Hericlys Matheus , Rodrigues Cléa Dometilde Soares , Rodrigues Ana Maria da Silveira
Published: July 2022

Enfermagem baseada em evidências se torna fundamental e decisiva no cuidado, gerando menores taxas de danos ao paciente e consequente redução no custo de internação. Assim, o uso da ultrassonografia em emergência fundamenta-se na prática baseada em evidência, complementando e oferecendo recursos de suporte metodológico no processo de enfermagem. Objetivo: compreender a perspectiva do profissional enfermeiro no uso da ultrassonografia no departamento de emergência. Metodologia: Trata-se de um estudo de revisão integrativa da literatura. Resultados: Após o uso dos mecanismos de busca e critérios pré-estabelecidos, pode-se encontrar um total de 19 artigos, disponíveis na íntegra e que responderam à questão norteadora deste estudo. Conclusão: Em suma, portanto, o uso pelo enfermeiro está respaldado e deve ser incentivado, já que permeia o processo de assistência em enfermagem em seu todo. Com conhecimento, habilidade e atitude frente ao uso, não ficam óbices para a utilização desse recurso de imagem.
Uso da gamificação com vistas à prevenção e promoção da saúde bucal: protocolo de revisão de escopo
Authors: Oliveira Luciana Bonfim Jacó de , Jorge Maria Salete Bessa
Published: July 2022

O objetivo é realizar um protocolo de revisão para mapear o uso da gamificação com vistas à prevenção e promoção da saúde bucal em crianças. Trata-se de um protocolo de pesquisa fundamentado nas recomendações do JBI, seguindo o checklist do Preferred Reporting Items for Systematic and Meta-Analyses- Extension for Scoping Reviews (PRISMA- ScR). Será realizada a busca e coleta de dados com os descritores da Ciência da Saúde (DeCS), Medical Subject Heading (MeSH) e na literatura cinzenta. A seleção dos estudos será feita por dois pesquisadores de forma independente. Esta revisão será previamente registrada no repositório Open Science Framework (OSF). Serão considerados materiais bibliográficos publicados e não publicados, conforme os seguintes critérios de inclusão: crianças (população), gamificação (conceito) e promoção da saúde bucal (contexto). Serão fontes de dados: Web of Science, SCIELO, PUBMED e Google acadêmico. Dois revisores independentes desenvolverão a análise de relevância dos artigos, a extração e síntese dos dados.
Associação entre a presença de distúrbio do sono dos cuidadores e bruxismo do sono em crianças: estudo observacional transversal
Authors: Bonacina Carlos Felipe , Gonçalves Ana Lurdes Conte Acunha , Olegário da Costa Isabel Cristina , Lira Adriana de Oliveria
Published: July 2022

A presente pesquisa visou avaliar qualidade do sono dos cuidadores de pacientes infantis e a percepção com bruxismo do sono em crianças mediante estudo transversal observacional. Após seleção de critérios de inclusão e exclusão, crianças e seus respectivos cuidadores foram avaliados, sendo que nas crianças foi investigada a presença de bruxismo e, nos cuidadores, foi aplicado o questionário de Pittsburgh para avaliação do padrão de sono. Para análise dos desfechos das variáveis qualidade do sono do cuidador: boa, ruim e presença de distúrbio do sono foi utilizado o teste de Qui-Quadrado (* p < 0,05 - 95%). Este estudo foi registrado segundo o protocolo CEP: 2.056.660. No total, 186 sujeitos foram avaliados: 93 crianças com idades entre 4 e 10 anos (média 6,3a), sendo 48 meninas, e 93 adultos cuidadores, sendo 82 mulheres. Deste total, a maior parte deles (46 indivíduos ou 49,4%) apresentou qualidade do sono ruim, 27 cuidadores (29,1%) apresentaram distúrbio do sono e a minoria deles (20 cuidadores ou 21,5%) apresentou uma boa qualidade do sono. Ao avaliar distúrbio do sono dos adultos, foi encontrada associação significativa entre aumento da frequência de relato de bruxismo do sono e uma qualidade ruim do sono do cuidador (p=0,022*). Conclui-se que cuidadores com qualidade boa de sono apresentaram menor frequência de relatos, enquanto cuidadores com qualidade de sono ruim relatam maior frequência de bruxismo do sono nas crianças.
Socioeconomic aspects of sport fisheries in a neotropical reservoir
Authors: Hillesheim Gustavo , Ladislau Daniel da Silva , Oliveira Werike Gustavo de , Fonseca José Rafael Soares , Gubiani Éder André
Published: July 2022

In economically emerging countries such as Brazil, sport fishing is emerging as an important social and economic contributor. However, despite its importance, some aspects still lack information, which jeopardizes the planning, mapping and proper management of the activity. Thus, the objective of this paper was to describe the socioeconomic profile of the sport fishermen of Itaipu Reservoir, Brazil, in order to provide subsidies for public and private investments in the promotion of regional fishing tourism. For this, semistructured socioeconomic questionnaires were given to sport fishermen (total respondents = 823 fishermen) participating in 19 sport fishing tournaments held at Itaipu Reservoir in 2015 and 2016. The majority of the fishermen that were interviewed were male (84%), married (65%), age 31-40 (31%) and had a high level of education (34%). The professional activities reported by the respondents were 43% entrepreneurs, 15% professionals, 15% public servants, 9% private sector workers and 7% students. The household income ranged from 3 to 6 times the Brazilian minimum wage (minimum wage R$ 954.00 = US$ 253.72, US$ 1 = R$ 3.76, October 2018) (34%). The expenditure on fishing events averaged US$ 140.33. The sport fishermen from Itaipu Reservoir demonstrated a high socioeconomic standard in relation to the fishermen from other regions of the country, which foments the local economy.
A COGNITIVE-PRAGMATIC STUDY OF AUSTRALIAN ENGLISH PHRASEOLOGY
Authors: KOZLOVA TETYANA , POLYEZHAYEV YURIY
Published: July 2022

Taking the intertwining of culture and cognition in a holistic nature of phraseologisms as a starting point, we investigate 400 units in Australian English from cognitive and pragmatic perspectives. It is argued that phraseologisms are formed on certain cognitive models that schematically represent real-world situations and shape the inner form of the expressions. The objectives of the study are to find out these models, explain how they configure the image component motivating the idiomatic meaning and pragmatic value of phraseologisms. The findings indicate that the flexibility of metonymy- and metaphor-based models allows a diversity of the inner forms which motivate idiomatic meanings and provide pragmatic efficiency of phraseologisms.
CITADELS AND SURVEILLANCE: CONFLICTIVE REGIONS AND DEFENSIVE DESIGN IN THE BUENAVISTA CITADELS OF GUATEMALA
Authors: Houston Stephen , Garrison Thomas , Alcover Firpi Omar Andrés
Published: July 2022

Maya conflict left many images. With a few exceptions, however, they reveal limited numbers of victors and captives In contrast, glyphic accounts point to broader convulsions, and the challenge remains of linking such conflicts to the infrastructure of concerted attack and defense. Lidar, a technology using laser pulses to record and model surfaces, does so with aplomb. By now, most Mayanists accept that, in the late 4th century A.D., Classic Maya kingdoms became entangled with the distant polity of Teotihuacan, Mexico. Tikal refers to that encounter in precise detail, identifying an enigmatic, victorious belligerent, Sihyaj K’ahk’, and possible ruptures in the local dynasty. To unexpected extent, lidar shows that the western entry to Tikal bristled with numerous citadels, surveillance platforms, moats with protected settlement, and ramps for rapid ascent and descent on high ridges and hilltops. Current evidence places these features in the general time of Sihyaj K’ahk’, underscoring that the threat and actuality of violence enmeshed regions, at systemic scale.
DIDACTICS AND COSMOS: HEAVEN AND HELL IN THE EARLY COLONIAL MURALS OF SANTA MARÍA XOXOTECO, HIDALGO, MEXICO
Authors: Clemmensen Mikkel Bøg
Published: July 2022

The 16th-century murals in the chapel of Santa María Xoxoteco, Hidalgo, are didactic artworks, painted within the first decades after the conquest with the purpose of converting the indigenous population to Christianity. In this article, I analyse the representations of heaven and hell in the murals, and I demonstrate how the artists chose motifs with meaning both in Christian and Mesoamerican cosmology. I discuss how the murals reflect a widespread method among the friars and the indigenous authors and artists of using Mesoamerican concepts and motifs to convey Christianity and facilitate the transition to the new religion. Firstly, I provide a description of the murals, and a review of their didactic function from the perspective of the Augustinian mission. I then turn to some of the lesser-studied parts of the murals: the paradise-representations in the vault – the flora, the zoomorphic and anthropomorphic creatures and the Solar-Christ – the mouth of hells on the sidewalls and the adjacent representations of Satan mixed with the characteristics of the tzitzimime, an Aztec class of deities branded by the early missionaries as devils.
THE PENINSULAR MAYA’S UNFINISHED SPIRITUAL CONQUEST
Authors: Williams-Beck Lorraine A.
Published: July 2022

Do Maya sacred artistic manifestations in sixteenth to eighteenth-century Franciscan convents, churches, and chapels reflect native ideological persistence, a Maya and Christian amalgamation, or a European Catholic subsumed spiritual meld? This study explores the sculptural and painted expressions that adorn Colonial religious architecture found in the Yucatan Peninsula. Ethnohistoric sources, historic documents, physical geographical location, and spatial layout for these buildings, their sculptural programs and mural painting iconographic motifs, and spiritual spaces surrounding those edifices erected by natives subsequent to European contact, conquest, and colonization provide a more complete basis from which to address such philosophical and anthropological concepts of religious permanence, syncretism, and/or fusion. These particular evidentiary aspects assess Maya sacred built space environments found in the Cehpech, Cochuah, Cupul, and Tases provinces prior to European contact and conquest. This paper will focus on twospecific areas: the municipal seat church and convent complex in one autonomous political jurisdiction near the Spanish viceregal administrative seat in Mérida, and will then compare/contrast those area-specific religious representations with built spaces and interior/exterior embellishments near the Spanish viceregal enclave at Valladolid, Yucatan, as well as in other indigenous community visita churches under this and Tizimin’s Missions ecclesiastical jurisdiction in the northeastern rural peninsular Maya hinterlands. Combined data sets from both regions suggest a more autonomously derived divine substrate to characterize viceroyalty period Maya religious practice, rather than a Roman Catholic and Maya syncretism or Catholic synthesis of autonomous ideological philosophy, and point to an unfinished evangelical conquest that flew under the ecclesiastical and Spanish administrative radar at that time. In some select cases these same hallowed essence and practices continue to present. Those spiritual expressions that embellish built environments with autonomous religious undercurrents also help to explain the repeated yet unsuccessful Franciscan endeavors to ultimately quash idolatry in the peninsular region.
Analisis Kerusakan Struktur Bangunan dan Manajemen Bencana Akibat Gempa Bumi, Tsunami, dan Likuifaksi di Palu
Authors: Tampubolon Sudarno P , Sarassantika I Putu Ellsa , Suarjana I Wayan Gede
Published: July 2022

Strong column-weak beam merupakan konsep desain yang perlu diterapkan dan diperhatikan dalam perencanaan struktur gedung (gedung bertingkat tinggi dan gedung bertingkat rendah). Umumnya kegagalan struktur terjadi pada sambungan balok-kolom (beam-column joint). Kegagalan tersebut terjadi karena kurangnya perhatian terhadap konsep desain yang baik dan benar. Detailing pembesian pada kolom, balok, dan sambungan balok-kolom masih belum secara penuh menerapkan standard SNI-2847-2019 yang mengakibatkan tulangan tidak berfungsi sepenuhnya dalam menahan kombinasi gaya tarik, tekan, dan geser yang terjadi saat gempa. Selain itu prinsip desain Strong column-weak beam yang tidak lengkap di dalam penerapan perencanaan bangunan mengakibatkan bangunan mengalami kegagalan pada struktur kolom saat menerima gaya axial. Tujuan penelitian ini adalah untuk menganalisis kerusakan struktur yang terjadi dan sistem manajemen bencana yang diterapkan saat terjadi gempa di Palu. Metode penelitian dilakukan dengan metode investigasi/survei ke lapangan dan melakukan pengecekan dan mencatat data mengenai kondisi kerusakan bangunan dan melakukan uji hammer test (pengujian nondestruktif) untuk mendapatkan nilai dari kekuatan beton. Dari hasil pengujian yang dilakukan diperoleh nilai kuat tekan beton f’c yang digunakan adalah (20-48) MPa. Selain itu detail penulangan sengkang stirrups juga belum sepenuhnya dipahami fungsinya pada balok maupun kolom yang mengakibatkan pemasangan tulangan sengkang tidak memenuhi kriteria aturan bengkokan sudut 90˚, 135˚, 180˚ dan penambahan panjang penyaluran tulangan tarik dan tekan. Potensi bahaya gempa yang tinggi mengakibatkan wilayah Palu dan sekitarnya cenderung memiliki risiko bencana gempa bumi. Untuk itu mitigasi bencana sangat perlu diterapkan di wilayah Palu yang bertujuan untuk mengurangi jumlah korban jiwa pada saat terjadi bencana alam, baik manusia maupun harta benda.
Legal Protection of Concurrent Creditors for The Debts That are not Guaranteed by Property Rights According to Bankruptcy Law and Islamic Law
Authors: Arifah Risma Nur , Adam Arman Safril
Published: July 2022

Bankruptcy is a condition where the debtor is unable to fulfill his obligations to pay debts to creditors. Revision of Law Number 4 of 1998 became Law Number. 37 of 2004 concerning Bankruptcy and Suspension of Debt Payment Obligations explains that concurrent creditors are creditors who do not hold collateral and who do not have special rights and whose claims are not recognized or recognized conditionally, of course, this causes the position of concurrent creditors to be very vulnerable to getting their rights back on the debt of the bankrupt debtor. This research is normative research using a statutory approach and a conceptual approach, where in this study the researcher examined the regulations on bankruptcy through the Act and analyzes the concept of legal protection for concurrent creditors. The results of the study showed that, first, Law Number 37 of 2004 concerning Bankruptcy and PKPU (Postponement of Debt Payment Obligations) explains that concurrent creditors are conditional creditors and do not have special rights, their position in paying off debtors' debts from the remaining proceeds from the settlement or auction of bankrupt assets. Second, Islamic law stipulates that the guaranteed of legal protection for creditors is to fulfill debt obligations as regulated in Surah al Baqarah verse 282 based on the principle of al ‘adalah.
The Role of Parents in Parenting from Islamic Law Perspectives: A Study of Muslim Families in Ambang II Village
Authors: Alimashariyanto M. , Sarib Suprijati , Mokodenseho Sabil
Published: July 2022

This study aims to analyze the role of parents in the upbringing of children from the perspective of Islamic law. The focus of this study is important because children are the next generation, and the embodiment of the future, so they must be nurtured because they are vulnerable to being affected by negative things. In addition, parents have a responsibility for the growth and development of children. The qualitative descriptive method was used to analyze the data. Research data were obtained from informants through interview and documentation techniques, in addition to written sources from books and journal articles. The results showed that parents in parenting activities do not only raise children but educate, guide, and protect children from childhood to adulthood in accordance with the values, norms, and culture adopted in the family and society. The choice of democratic, authoritarian, and permissive parenting in parenting activities has implications for the formation of the socio-religious spirit of children in society in a better direction. In conclusion, the role of parents in every stage and development of children is very necessary while considering the use of appropriate parenting patterns.
EFEKTIVITAS SENAM OTAK (BRAIN GYM) DALAM MENURUNKAN TINGKAT KEJENUHAN PERKULIAHAN DARI RUMAH SELAMA MASA PANDEMI COVID – 19
Authors: Kurniawan Dede Tri , Maryanti Sri
Published: July 2022

Fenomena Study From Home di masa Pandemi Covid-19 seringkali membuat mahasiswa merasa jenuh. Sudah lebih dari dua bulan sejak diberlakukannya kebijakan untuk work from home. Segala kegiatanpun dialihkan secara online dari rumah, termasuk kegiatan perkuliahan. Selama beberapa lama di rumah saja, wajar jika rasa jenuh dan bosan mulai dirasakan. Fokuspun mulai terganggu yang berujung pada sulitnya memahami materi saat kuliah online. Dari hal itu peneliti meurumuskan masalah bagaimana efektivitas senam otak (brain gym) menurunkan tingkat kejenuhan mahasiswa. Penelitian ini bertujuan untuk mengetahui apakah senam otak (brain gym) efektif dalam menurunkan tingkat kejenuhan belajar (burnout) pada mahasiswa calon guru Raudhatul Athfal (RA). Solusi yang bisa dilakukan agar mahasiswa menjadi lebih aktif dan lebih bisa dengan mudah menerima pelajaran yang disampaikan oleh dosen salah satunya yaitu dengan melakukan senam otak atau bisa disebut dengan brain gym. Dalam penelitian ini peneliti merumuskan masalah yaitu: apakah senam otak efektif dalam menurunkan tingkat kejenuhan mahasiswa dan bagaimana cara senam otak dalam menurunkan kejenuhan mahasiswa calon guru Raudhatul Athfal (RA)? Jenis Penelitian ini adalah penelitian deskriptif kualitatif. Pengumpulan data dilakukan dengan cara observasi, wawancara dan dokumentasi. Hasil penelitian menunjukan bahwa brain gym mampu menurunkan tingkat kejenuhan mahasiswa selama perkuliahan masa pandemi covid-19. Selain mahasiswa tidak jenuh mahasiswa juga lebih konsentrasi fokus dan membantu meningkatkan motivasi. Beberapa gerakan senam otak dapat membantu efektivitas perkuliahan dalam jaringan sehingga meningkatkan fokus konsentrasi dan pemahaman, membantu meningkatkan konsentrasi, meningkatkan konsentrasi dan fokus, dan membantu meningkatkan motivasi.
ANALISIS MOTIVASI BELAJAR SISWA KELAS X IPA TERHADAP MATA PELAJARAN FISIKA DI SMA N 6 MUARO JAMBI
Authors: Putri Wita Ardina , Meliza Wella , Astuti Yuli
Published: July 2022

Penelitian ini merupakan penelitian kuantitatif. Penelitian ini bertujuan untuk menganalisis serta mengetahui motivasi belajar peserta didik kelas X di SMA N 6 Muaro Jambi terhadap mata pelajaran fisika. Penelitian ini menggunakan metode penelitian survey. Dimana penelitian ini dilakukan dengan cara menyebarkan kuisioner atau yang biasa disebut dengan angket secara online kepada peserta didik. Setelah melakukan penyebaran angket dan memperoleh data yang diinginkan, selanjutnya peneliti mengelolah data menggunakan spss dengan teknik desktiprif. Hasil yang diperoleh dari penelitian ini kemudian dijelaskan melalui deskriptif kuantitatif dalam bentuk tabel yang terdiri dari presentase motivasi belajar peserta didik. Adapun perolehan presentase motivasi belajar fisika dari peserta didik kelas X di SMA N 6 Muaro Jambi yaitu 0% yang dapat dikatakan tidak baik, 5% cukup baik, 78,3 % baik, dan 16,7% sangat baik. Berdasarkan hasil  prosentase motivasi belajar peserta didik di SMAN 6 Muaro Jambi, maka dapat dikatakan bahwa motivasi belajar peserta didik di SMAN 6 Muaro Jambi terhadap mata pelajaran fisika sudah baik..
ANDROID-BASED INTERACTIVE SCIENCE LEARNING (GeNda MaHiLingTar): AN APPLICATION DEVELOPMENT
Authors: Magfiroh Ririn Isna , Kisdiyanti Adinda Ayu , Fikri Achmad Ali
Published: July 2022

Along with the development technology , teachers should make interesting and interactive science teaching materials for increase interest study students . There are many media that can be used for support learning IPA.iSpring is a device soft supporters who can help the teacher in resolve problem that . because _ that , research this aim for develop application interactive science learning for increase interest and understanding learn science at MTs Nurul Burhan Blingoh Donorojo on the subject of Motion of Objects and Living Things in the Environment Approx . With method RnD 3D model research has conducted from September to December 2021. Results of study this is said to be valid because results validation and eligibility above 80%, based on criteria feasibility of learning media and results from percentage Validation media expert and expert Theory of 86.17% and the percentage of the feasibility test product 80.27%.
Peningkatan Pengetahuan Petugas Ahli Teknologi Laboratorium Medis (ATLM) di Klinik Utama Bunga Emas Terkait Manajemen Laboratorium
Authors: Parwati Putu Ayu
Published: July 2022

Manajemen laboratorium merupakan usaha untuk mengelola laboratorium. Suatu laboratorium dapat dikelola dengan baik sangat ditentukan oleh beberapa faktor yang saling berkaitan satu dengan lainnya. Oleh karena itu, manajemen laboratorium adalah salah satu bagian yang tidak dapat dipisahkan dengan kegiatan laboratorium sehari-hari. Untuk menghasilkan pemeriksaan laboratorium yang dapat dipercaya/ bermutu, maka setiap tahap pemeriksaan laboratorium harus dikendalikan. Pengendalian setiap tahap ini untuk mengurangi atau meminimalisir kesalahan yang terjadi di laboratorium. Mutu laboratorium klinik meliputi mutu hasil pemeriksaan dan mutu layanan. Kegiatan ini bertujuan untuk meningkatkan pengetahuan dengan memberikan informasi kepada ATLM  terkait manajemen laboratorium. Metode kegiatan yang digunakan yaitu penyuluhan dan pengukuran tingkat pengetahuan ATLM terkait manajemen laboratorium. Hasil kegiatan yaitu terdapat perbedaan hasil pre-test dan post-test yang diberikan kepada petugas ATLM. Hal ini menunjukkan bahwa penyuluhan yang dilakukan memberikan tambahan ilmu terkait manajemen laboratorium. Melalui kegiatan ini diharapkan peserta mampu mengaplikasikan manajemen mutu laboratorium dalam proses pelayanan di laboratorium klinik
Assessment of Soft Actuators for Hand Exoskeletons: Pleated Textile Actuators and Fiber-Reinforced Silicone Actuators
Authors: Ramos Orion , Múnera Marcela , Moazen Mehran , Wurdemann Helge , Cifuentes Carlos A.
Published: July 2022

Soft robotic approaches have been trialed for rehabilitation or assistive hand exoskeletons using silicone or textile actuators because they have more tolerance for alignment with biological joints than rigid exoskeletons. Textile actuators have not been previously evaluated, and this study compares the mechanical properties of textile and silicone actuators used in hand exoskeletons. The physical dimensions, the air pressure required to achieve a full bending motion, and the forces generated at the tip of the actuator were measured and compared. The results showed that the construction method of the silicone actuators is slower than the textile actuators, but it generates better dimensional accuracy. However, the air pressure required for the actuators to generate a full bending motion is significantly lower for textile actuators, and the blocking force generated at that pressure is 35% higher in the textile actuators. There are significant differences across all variables compared, indicating that actuators constructed using pleated textile techniques have greater potential for the construction of an exoskeleton for hand rehabilitation or assistance.
ERK5 Signalling and Resistance to ERK1/2 Pathway Therapeutics: The Path Less Travelled?
Authors: Cook Simon J. , Lochhead Pamela A.
Published: July 2022

The RAS-regulated RAF-MEK1/2-ERK1/2 signalling pathway is frequently de-regulated in human cancer. Melanoma in particular exhibits a high incidence of activating BRAFV600E/K and NRASQ61L/K mutations and such cells are addicted to the activity of these mutant oncoproteins. As a result three different BRAF inhibitors (BRAFi) have now been approved for BRAFV600E/K- mutant melanoma and have transformed the treatment of this disease. Despite this, clinical responses are typically transient as tumour cells develop resistance. These resistance mechanisms frequently involve reinstatement of ERK1/2 signalling and BRAFi are now deployed in combination with one of three approved MEK1/2 inhibitors (MEKi) to provide more durable, but still transient, clinical responses. Furthermore, inhibitors to ERK1/2 (ERK1/2i) have also been developed to counteract ERK1/2 signalling. However, recent studies have suggested that BRAFi/MEKi and ERK1/2i resistance can arise through activation of a parallel signalling pathway leading to activation of ERK5, an unusual protein kinase that contains both a kinase domain and a transcriptional transactivation domain. Here we review the evidence supporting ERK5 as a mediator of BRAFi/MEKi and ERK1/2i resistance. We also review the challenges in targeting ERK5 signalling with small molecules, including paradoxical activation of the transcriptional transactivation domain, and discuss new therapeutic modalities that could be employed to target ERK5.
Manipulation of the Tubulin Code Alters Directional Cell Migration and Ciliogenesis
Authors: Müller Manuel , Gorek Lena , Kamm Natalia , Jacob Ralf
Published: July 2022

Conjunction of epithelial cells into monolayer sheets implies the ability to migrate and to undergo apicobasal polarization. Both processes comprise reorganization of cytoskeletal elements and rearrangements of structural protein interactions. We modulated expression of tubulin tyrosin ligase (TTL), the enzyme that adds tyrosine to the carboxy terminus of detyrosinated α-tubulin, to study the role of tubulin detyrosination/-tyrosination in the orientation of cell motility and in epithelial morphogenesis. Oriented cell migration and the organization of focal adhesions significantly lose directionality with diminishing amounts of microtubules enriched in detyrosinated tubulin. On the other hand, increasing quantities of detyrosinated tubulin results in faster plus end elongation of microtubules in migrating and in polarized epithelial cells. These plus ends are decorated by the plus end binding protein 1 (EB1), which mediates interaction between microtubules enriched in detyrosinated tubulin and the integrin-ILK complex at focal adhesions. EB1 accumulates at the apical cell pole at the base of the primary cilium following apicobasal polarization. Polarized cells almost devoid of detyrosinated tubulin form stunted primary cilia and multiluminal cysts in 3D-matrices. We conclude that the balance between detyrosinated and tyrosinated tubulin alters microtubule dynamics, affects the orientation of focal adhesions and determines the organization of primary cilia on epithelial cells.
Tunneling Nanotubes Facilitate Intercellular Protein Transfer and Cell Networks Function
Authors: Turos-Korgul Laura , Kolba Marta Dorota , Chroscicki Piotr , Zieminska Aleksandra , Piwocka Katarzyna
Published: July 2022

The past decade witnessed a huge interest in the communication machinery called tunneling nanotubes (TNTs) which is a novel, contact-dependent type of intercellular protein transfer (IPT). As the IPT phenomenon plays a particular role in the cross-talk between cells, including cancer cells as well as in the immune and nervous systems, it therefore participates in remodeling of the cellular networks. The following review focuses on the placing the role of tunneling nanotube-mediated protein transfer between distant cells. Firstly, we describe different screening methods used to study IPT including tunneling nanotubes. Further, we present various examples of TNT-mediated protein transfer in the immune system, cancer microenvironment and in the nervous system, with particular attention to the methods used to verify the transfer of individual proteins.
JAK2 Alterations in Acute Lymphoblastic Leukemia: Molecular Insights for Superior Precision Medicine Strategies
Authors: Downes Charlotte EJ. , McClure Barbara J. , McDougal Daniel P. , Heatley Susan L. , Bruning John B. , Thomas Daniel , Yeung David T. , White Deborah L.
Published: July 2022

Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, arising from immature lymphocytes that show uncontrolled proliferation and arrested differentiation. Genomic alterations affecting Janus kinase 2 (JAK2) correlate with some of the poorest outcomes within the Philadelphia-like subtype of ALL. Given the success of kinase inhibitors in the treatment of chronic myeloid leukemia, the discovery of activating JAK2 point mutations and JAK2 fusion genes in ALL, was a breakthrough for potential targeted therapies. However, the molecular mechanisms by which these alterations activate JAK2 and promote downstream signaling is poorly understood. Furthermore, as clinical data regarding the limitations of approved JAK inhibitors in myeloproliferative disorders matures, there is a growing awareness of the need for alternative precision medicine approaches for specific JAK2 lesions. This review focuses on the molecular mechanisms behind ALL-associated JAK2 mutations and JAK2 fusion genes, known and potential causes of JAK-inhibitor resistance, and how JAK2 alterations could be targeted using alternative and novel rationally designed therapies to guide precision medicine approaches for these high-risk subtypes of ALL.
The Origin and Evolution of Bladder Cancer Stem Cells
Authors: Tan Jiufeng , Wang Yao , Sun Lihui , Xu Siqi , Li Charles , Jin Xuefei
Published: July 2022

Bladder cancer is the most common malignant tumor of the urinary system. Bladder cancer stem cells (BCSCs) play key roles in tumor initiation, metastasis, relapse and drug-resistance. Investigation of BCSCs is of great value. On the basis of a review of normal bladder stem cells and universal cancer stem cells (CSCs), we summarize the origin of BCSCs, isolation and identification of CSCs from bladder cancer, signaling pathway of BCSCs, BCSCs targeted therapy, and relationship of BCSCs with non-muscle invasiveness and muscle invasiveness. This review aims to provide better elucidation about BCSCs, and provide constructive data for classification, prognosis, treatment and early intervention of bladder cancer.
An Efficient Modern Strategy to Screen Drug Candidates Targeting RdRp of SARS-CoV-2 With Potentially High Selectivity and Specificity
Authors: Zhang Haiping , Gong Xiaohua , Peng Yun , Saravanan Konda Mani , Bian Hengwei , Zhang John Z. H. , Wei Yanjie , Pan Yi , Yang Yang
Published: July 2022

Desired drug candidates should have both a high potential binding chance and high specificity. Recently, many drug screening strategies have been developed to screen compounds with high possible binding chances or high binding affinity. However, there is still no good solution to detect whether those selected compounds possess high specificity. Here, we developed a reverse DFCNN (Dense Fully Connected Neural Network) and a reverse docking protocol to check a given compound’s ability to bind diversified targets and estimate its specificity with homemade formulas. We used the RNA-dependent RNA polymerase (RdRp) target as a proof-of-concept example to identify drug candidates with high selectivity and high specificity. We first used a previously developed hybrid screening method to find drug candidates from an 8888-size compound database. The hybrid screening method takes advantage of the deep learning-based method, traditional molecular docking, molecular dynamics simulation, and binding free energy calculated by metadynamics, which should be powerful in selecting high binding affinity candidates. Also, we integrated the reverse DFCNN and reversed docking against a diversified 102 proteins to the pipeline for assessing the specificity of those selected candidates, and finally got compounds that have both predicted selectivity and specificity. Among the eight selected candidates, Platycodin D and Tubeimoside III were confirmed to effectively inhibit SARS-CoV-2 replication in vitro with EC50 values of 619.5 and 265.5 nM, respectively. Our study discovered that Tubeimoside III could inhibit SARS-CoV-2 replication potently for the first time. Furthermore, the underlying mechanisms of Platycodin D and Tubeimoside III inhibiting SARS-CoV-2 are highly possible by blocking the RdRp cavity according to our screening procedure. In addition, the careful analysis predicted common critical residues involved in the binding with active inhibitors Platycodin D and Tubeimoside III, Azithromycin, and Pralatrexate, which hopefully promote the development of non-covalent binding inhibitors against RdRp.
Analyzing the Influence of Imaging Resolution on Polarization Properties of Scattering Media Obtained From Mueller Matrix
Authors: Shao Conghui , Chen Binguo , He Honghui , He Chao , Shen Yuanxing , Zhai Haoyu , Ma Hui
Published: July 2022

The Mueller matrix contains abundant micro- and even nanostructural information of media. Especially, it can be used as a powerful tool to characterize anisotropic structures quantitatively, such as the particle size, density, and orientation information of fibers in the sample. Compared with unpolarized microscopic imaging techniques, Mueller matrix microscopy can also obtain some essential structural information about the sample from the derived parameters images at low resolution. Here, to analyze the comprehensive effects of imaging resolution on polarization properties obtained from the Mueller matrix, we, first, measure the microscopic Mueller matrices of unstained rat dorsal skin tissue slices rich in collagen fibers using a series of magnifications or numerical aperture (NA) values of objectives. Then, the first-order moments and image texture parameters are quantified and analyzed in conjunction with the polarization parameter images. The results show that the Mueller matrix polar decomposition parameters diattenuation D, linear retardance δ, and depolarization Δ images obtained using low NA objective retain most of the structural information of the sample and can provide fast imaging speed. In addition, the scattering phase function analysis and Monte Carlo simulation based on the cylindrical scatterers reveal that the diattenuation parameter D images with different imaging resolutions are expected to be used to distinguish among the fibrous scatterers in the medium with different particle sizes. This study provides a criterion to decide which structural information can be accurately and rapidly obtained using a transmission Mueller matrix microscope with low NA objectives to assist pathological diagnosis and other applications.
Luminescence Thermometry for Brain Activity Monitoring: A Perspective
Authors: Rodríguez-Sevilla Paloma , Marin Riccardo , Ximendes Erving , del Rosal Blanca , Benayas Antonio , Jaque Daniel
Published: July 2022

Minimally invasive monitoring of brain activity is essential not only to gain understanding on the working principles of the brain, but also for the development of new diagnostic tools. In this perspective we describe how brain thermometry could be an alternative to conventional methods (e.g., magnetic resonance or nuclear medicine) for the acquisition of thermal images of the brain with enough spatial and temperature resolution to track brain activity in minimally perturbed animals. We focus on the latest advances in transcranial luminescence thermometry introducing a critical discussion on its advantages and shortcomings. We also anticipate the main challenges that the application of luminescent nanoparticles for brain thermometry will face in next years. With this work we aim to promote the development of near infrared luminescence for brain activity monitoring, which could also benefit other research areas dealing with the brain and its illnesses.
Identifying the Barriers and Opportunities in the Provision and Use of Weather and Climate Information for Flood Risk Preparedness: The Case of Katakwi District, Uganda
Authors: Mitheu Faith , Petty Celia , Tarnavsky Elena , Stephens Elisabeth , Ciampi Luisa , Butsatsa Jonah , Cornforth Rosalind
Published: July 2022

The provision of weather and climate information (WCI) can help the most at-risk communities cope and adapt to the impacts of extreme events. While significant progress has been made in ensuring improved availability of WCI, there remain obstacles that hinder the accessibility and use of this information for adaptation planning. Attention has now focused on the “usability gap” to ensure useful and usable WCI informs practise. Less attention has however been directed on barriers to the active production and use of WCI. In this study, we combine two frameworks through a bottom-up approach to present a more coordinated institutional response that would be required to ensure a better flow of information from information providers to users at community level and vice versa. The bottom-up approach was designed in form of Farmers Agri-Met Village Advisory Clinics (FAMVACs) and Listening Groups (LG) and was initiated by Uganda Meteorological Authority (UNMA) as a way of ensuring connections between the information providers, the disseminators, and the communities to specifically give voice to the communities to provide feedback on the use of WCI in coping with flood risks. This approach is used to identify the barriers and opportunities in the production/provision and use of WCI for flood risk preparedness for a case study in Eastern Uganda. First, a use-case is developed for Katakwi District where smallholder farming communities have recorded their coping practises and barriers to the use of WCI in practise. Second, online interviews with practitioners from disaster management institutions are used to identify barriers to the production and provision of WCI to local farming communities. Findings show that for providers, barriers such as accessibility and completeness of data hinder the production of useful WCI. In situations where useful information is available, technical language used in the format and timeliness in dissemination hinder usability by local farmers. Useful and usable WCI may not be acted on in practise due to factors such as costs or market availability e.g., lack of access to improved seeds. Further, the study highlights possible solutions to bridge the identified gaps and they include capacity building, fostering data collaborations across sectors, data translation to simple advisories, among others. The study also presents the FAMVACs approach which shows the importance of a more coordinated response with a shift of focus from the users of information only, to a more inclusive understanding of the data and information gaps across the wider provider-user landscapes. We argue that this would contribute to more effective disaster management at both the national and local levels.
Pre-existing Psychiatric Morbidity Is Strongly Associated to Takotsubo Syndrome: A Case-Control Study
Authors: Pozzi Gino , D'Amario Domenico , Princi Giuseppe , Ciliberti Giuseppe , Irano Antonella , Simone Maria Velia , Crea Filippo , Galiuto Leonarda
Published: July 2022

Background

Takotsubo syndrome (TTS) is an emerging disease characterized by an acute and reversible myocardial dysfunction which may have an influence on clinical status and prognosis. Despite extensive research, its pathophysiology has not been completely elucidated; among other hypothesis, a heart-brain interaction has been proposed.

Methods

The aim of this study was to assess the impact of psychiatric disorders and of some personality types on the pathogenesis of TTS. We conducted a retrospective observational case-control study. We enrolled a total of 50 patients, 25 with a previous diagnosis of TTS and 25 patients with a history of acute coronary syndrome (ACS), that underwent a comprehensive lifetime psychiatric assessment.

Results

We found no significant difference between TTS and ACS patients in cardiovascular risk profile. The frequency of lifetime psychiatric disorders was significantly greater in TTS. In particular, in the univariate analysis, TTS group showed a higher prevalence of mood disorders (Major Depressive Disorder, Bipolar Disorder, Dysthymia; 16 vs. 2, P < 0.001) and anxiety disorder (Generalized Anxiety Disorder, Panic Disorder, Agoraphobia; 20 vs. 8, P = 0.001) compared with ACS group. There was also a significant tendency in TTS patients to psychotropic medication use, substance abuse, and psychologist or psychiatrist consulting. However, there was no difference between the groups in previous stressful events and Type D personality. Moreover, the multivariate analysis showed that mood disorders were independently associated with TTS (OR 16.9, 95% CI, 2.2–127).

Conclusion

Our study demonstrated that pre-existing anxiety disorders and mostly mood disorders were significantly higher in TTS patients than in ACS group, suggesting the role of psychiatric disorders as possible pathophysiological substrate of TTS.