bluuebunny/crossref_metadata_2025 huggingface dataset:
Research on Wickerwork Patterns Creative Design and Development Based on Style Transfer Technology
Authors: Wang Tianxiong , Ma Zhiqi , Zhang Fan , Yang Liu
Published: January 2023

Traditional craftsmanship and culture are facing a transformation in modern science and technology development, and the cultural industry is gradually stepping into the digital era, which can realize the sustainable development of intangible cultural heritage with the help of digital technology. To innovatively generate wickerwork pattern design schemes that meets the user’s preferences, this study proposes a design method of wickerwork patterns based on a style migration algorithm. First, an image recognition experiment using residual network (ResNet) based on the convolutional neural network is applied to the Funan wickerwork patterns to establish an image recognition model. The experimental results illustrate that the optimal recognition rate is 93.37% for the entire dataset of ResNet50 of the pattern design images, where the recognition rate of modern patterns is 89.47%, while the recognition rate of traditional patterns is 97.14%, the recognition rate of wickerwork patterns is 95.95%, and the recognition rate of personality is 90.91%. Second, based on Cycle-Consistent Adversarial Networks (CycleGAN) to build design scheme generation models of the Funan wickerwork patterns, CycleGAN can automatically and innovatively generate the pattern design scheme that meets certain style characteristics. Finally, the designer uses the creative images as the inspiration source and participates in the detailed adjustment of the generated images to design the wickerwork patterns with various stylistic features. This proposed method could explore the application of AI technology in wickerwork pattern development, and providing more comprehensive and rich new material for the creation of wickerwork patterns, thus contributing to the sustainable development and innovation of traditional Funan wickerwork culture. In fact, this digital technology can empower the inheritance and development of more intangible cultural heritages.
Cooperative Use of IMD and GPT in a 3-Phase Ungrounded Distribution System Linked to a Transformerless Photovoltaic Power Generation Facility
Authors: Lee Hyeon-Myeong , Chae Woo-Kyu , Kim Woo-Hyun , Kim Jae-Eon
Published: January 2023

Distributed generations, using solar photovoltaic (PV) generation systems, are generally connected to ungrounded distribution systems to ensure operational continuity and avoid electro-chemical corrosions. The ungrounded power distribution system possesses an advantage of continuous operation regardless of primary fault occurrence due to a small fault current. Conversely, a subsequent secondary fault can induce a large fault current representing that of other electrical grounding types, resulting in inevitable power shutdowns. As preventative methods, both insulation status monitoring and primary failure detection have become of high importance. This paper presents a method enabling the cooperative use of IMD (Insulation Monitoring Device) and GPT (Ground Potential Transformer) in an ungrounded distribution system connected with a transformerless inverter. Moreover, factors leading to errors during IMD insulation monitoring, CLR (Current Limit Resistor) burnout of a GPT, and malfunctions of related protection devices are presented. Furthermore, a method for selecting the inductor and capacitor in consideration of the operating characteristics of IMD and GPT is discussed. The proposed cooperative operation method enables the accurate measurement of insulation resistance using IMD, while concurrently reducing the constitutively induced zero-sequence voltage in the CLR of a GPT to prevent CLR burnouts and malfunctions of connected protection devices. Hence, the method is anticipated to contribute to the stable operation of alternating current (AC) and Direct Current (DC) combined systems connected with transformerless inverters.
Study of Loads Acting on the Load during the Sudden Braking of a Vehicle
Authors: Zuska Andrzej , Kurczyński Dariusz , Jackowski Jerzy Tomasz
Published: January 2023

This article presents the results of a study of the braking process in terms of assessing the longitudinal loading condition of transported cargo. The existing methods of securing cargo do not take into consideration the type of vehicle used to transport the cargo. This may result in cargo not being transported in compliance with the principles of proper cargo protection. This paper discusses the differences in maximum deceleration values achieved by different types of vehicles that are structurally suitable for freight transport. As a result of these differences in deceleration values, the values of forces acting on the transported cargo are also different. This paper presents and analyses the results of road tests that entailed the heavy braking of two vehicles structurally suitable for freight transport. One of them was a delivery vehicle, while the other was a semi-trailer truck. The experiment was carried out in six measurement series. Four of them were performed on an asphalt pavement, while the other two on a concrete pavement. One series included ten brake tests. Deceleration values registered during the tests were later used to determine the values of coefficient Cx, which were then compared with standardised values. It has been shown that failure to take into account in the selection process of cargo securing equipment, vehicle category, and type and condition of the pavement can result in cargo displacement and even traffic incidents.
Autonomous Visual Navigation System Based on a Single Camera for Floor-Sweeping Robot
Authors: Rao Jinjun , Bian Haoran , Xu Xiaoqiang , Chen Jinbo
Published: January 2023

The indoor sweeping robot industry has developed rapidly in recent years. The current sweeping robot environment perception sensor configuration is more diverse and generally does not have active garbage detection capabilities. Advances in computer vision technology, artificial intelligence, and cloud computing technology have provided new possibilities for the development of sweeping robot technology. This paper conceptualizes a new autonomous visual navigation system based on a single-camera sensor for floor-sweeping robots. It investigates critical technologies such as floor litter recognition, environmental perception, and dynamic local path planning based on depth maps. The system is applied to the TurtleBot robot for experiments, and the results show that the mAP accuracy of the autonomous visual navigation system for fine trash recognition is 91.28%; it reduces the average relative error of depth perception by 10.4% compared to conventional methods. Moreover, it has greatly improved the dynamics and immediacy of path planning.
A Literature Survey on Electrical-Current-Assisted Friction Stir Welding
Authors: Sajed Moosa , Guerrero John William Grimaldo , Derazkola Hamed Aghajani
Published: January 2023

Electrical-current-assisted friction stir welding (EA-FSW) is a procedure developed for the joining of similar and dissimilar materials. EA-FSW is a newly invented solid-state process to increase welded components’ efficacy in various applications, such as marine structures. EA-FSW joints have investigated the dissimilar joints on aluminum–magnesium, aluminum–steel, and polymer-to-steel. Similar joints have been performed on aluminum, magnesium, and steel. The main parameters that affect the temperature of the nugget in EA-FSW are electrical current and tool rotational velocity. This review paper presents the fundamental principle of EA-FSW, its processes mechanism, and various types of tools, and discusses the different joints that EA-FSW welded. The effect of electrical current on the quality of similar and dissimilar joints is discussed. The simulation process and detailed modeling of the EA-FSW process are discussed in the last section.
MEC: A Mesoscale Events Classifier for Oceanographic Imagery
Authors: Pieri Gabriele , Janeiro João , Martins Flávio , Papini Oscar , Reggiannini Marco
Published: January 2023

The observation of the sea through remote sensing technologies plays a fundamentalan role in understanding the state of health of marine fauna species and their behaviour. Mesoscale phenomena, such as upwelling, countercurrents, and filaments, are essential processes to be analysed because their occurrence involves, among other things, variations in the density of nutrients, which, in turn, influence the biological parameters of the habitat. Indeed, there is a connection between the biogeochemical and physical processes that occur within a biological system and the variations observed in its faunal populations. This paper concerns the proposal of an automatic classification system, namely the Mesoscale Events Classifier, dedicated to the recognition of marine mesoscale events. The proposed system is devoted to the study of these phenomena through the analysis of sea surface temperature images captured by satellite missions, such as EUMETSAT’s Metop and NASA’s Earth Observing System programmes. The classification of these images is obtained through (i) a preprocessing stage with the goal to provide a simultaneous representation of the spatial and temporal properties of the data and enhance the salient features of the sought phenomena, (ii) the extraction of temporal and spatial characteristics from the data and, finally, (iii) the application of a set of rules to discriminate between different observed scenarios. The results presented in this work were obtained by applying the proposed approach to images acquired in the southwestern region of the Iberian peninsula.
From Oxytocin to Compassion: The Saliency of Distress
Authors: Kucerova Barbora , Levit-Binnun Nava , Gordon Ilanit , Golland Yulia
Published: January 2023

Compassion is a warm response of care and concern for those who are suffering, which drives individuals to devote their resources for the sake of others. A prominent neuroevolutionary framework grounds compassion in the neurobiology of the mammalian caregiving system. Accordingly, it has been suggested that the oxytocinergic system, which plays a central role in parental caregiving and bonding, provides the neurobiological foundation for compassion towards strangers. Yet, the specific role of oxytocin in compassion is far from clear. The current paper aims to target this gap and offer a theoretical framework that integrates the state-of-the-art literature on oxytocin with research on compassion. We suggest that oxytocin mediates compassion by enhancing the saliency of cues of pain and distress and discuss the plausible underlying neurobiological substrates. We further demonstrate how the proposed framework can account for individual differences in compassion, focusing on the effects of attachment on caregiving and support. The proposed framework integrates the current scientific understanding of oxytocin function with compassion-related processes. It thus highlights the largely ignored attentional processes in compassion and taps into the vast variability of responses in social contexts involving pain and suffering.
Using SXRF and LA-ICP-TOFMS to Explore Evidence of Treatment and Physiological Responses to Leprosy in Medieval Denmark
Authors: Brozou Anastasia , Mannino Marcello A. , Van Malderen Stijn J. M. , Garrevoet Jan , Pubert Eric , Fuller Benjamin T. , Dean M. Christopher , Colard Thomas , Santos Frédéric , Lynnerup Niels , Boldsen Jesper L. , Jørkov Marie Louise , Soficaru Andrei Dorian , Vincze Laszlo , Le Cabec Adeline
Published: January 2023

Leprosy can lead to blood depletion in Zn, Ca, Mg, and Fe and blood enrichment in Cu. In late medieval Europe, minerals were used to treat leprosy. Here, physiological responses to leprosy and possible evidence of treatment are investigated in enamel, dentine, and cementum of leprosy sufferers from medieval Denmark (n = 12) and early 20th century Romania (n = 2). Using SXRF and LA-ICP-TOFMS, 12 elements were mapped in 15 tooth thin sections, and the statistical covariation of paired elements was computed to assess their biological relevance. The results show marked covariations in the Zn, Ca, and Mg distributions, which are compatible with clinical studies but cannot be directly attributed to leprosy. Minerals used historically as a treatment for leprosy show no detectable intake (As, Hg) or a diffuse distribution (Pb) related to daily ingestion. Intense Pb enrichments indicate acute incorporations of Pb, potentially through the administration of Pb-enriched medication or the mobilization of Pb from bone stores to the bloodstream during intense physiological stress related to leprosy. However, comparisons with a healthy control group are needed to ascertain these interpretations. The positive correlations and the patterns observed between Pb and essential elements may indicate underlying pathophysiological conditions, demonstrating the potential of SXRF and LA-ICP-TOFMS for paleopathological investigations.
The Matricellular Protein Hevin Is Involved in Alcohol Use Disorder
Authors: Nuñez-delMoral Amaia , Bianchi Paula C. , Brocos-Mosquera Iria , Anesio Augusto , Palombo Paola , Camarini Rosana , Cruz Fabio C. , Callado Luis F. , Vialou Vincent , Erdozain Amaia M.
Published: January 2023

Astrocytic-secreted matricellular proteins have been shown to influence various aspects of synaptic function. More recently, they have been found altered in animal models of psychiatric disorders such as drug addiction. Hevin (also known as Sparc-like 1) is a matricellular protein highly expressed in the adult brain that has been implicated in resilience to stress, suggesting a role in motivated behaviors. To address the possible role of hevin in drug addiction, we quantified its expression in human postmortem brains and in animal models of alcohol abuse. Hevin mRNA and protein expression were analyzed in the postmortem human brain of subjects with an antemortem diagnosis of alcohol use disorder (AUD, n = 25) and controls (n = 25). All the studied brain regions (prefrontal cortex, hippocampus, caudate nucleus and cerebellum) in AUD subjects showed an increase in hevin levels either at mRNA or/and protein levels. To test if this alteration was the result of alcohol exposure or indicative of a susceptibility factor to alcohol consumption, mice were exposed to different regimens of intraperitoneal alcohol administration. Hevin protein expression was increased in the nucleus accumbens after withdrawal followed by a ethanol challenge. The role of hevin in AUD was determined using an RNA interference strategy to downregulate hevin expression in nucleus accumbens astrocytes, which led to increased ethanol consumption. Additionally, ethanol challenge after withdrawal increased hevin levels in blood plasma. Altogether, these results support a novel role for hevin in the neurobiology of AUD.
Impaired Function of Solute Carrier Family 19 Leads to Low Folate Levels and Lipid Droplet Accumulation in Hepatocytes
Authors: Cano Ainara , Vazquez-Chantada Mercedes , Conde-Vancells Javier , Gonzalez-Lahera Aintzane , Mosen-Ansorena David , Blanco Francisco J. , Clément Karine , Aron-Wisnewsky Judith , Tran Albert , Gual Philippe , García-Monzón Carmelo , Caballería Joan , Castro Azucena , Martínez-Chantar María Luz , Mato José M. , Zhu Huiping , Finnell Richard H. , Aransay Ana M.
Published: January 2023

Low serum folate levels are inversely related to metabolic associated fatty liver disease (MAFLD). The role of the folate transporter gene (SLC19A1) was assessed to clarify its involvement in lipid accumulation during the onset of MAFLD in humans and in liver cells by genomic, transcriptomic, and metabolomic techniques. Genotypes of 3 SNPs in a case-control cohort were initially correlated to clinical and serum MAFLD markers. Subsequently, the expression of 84 key genes in response to the loss of SLC19A1 was evaluated with the aid of an RT2 profiler-array. After shRNA-silencing of SLC19A1 in THLE2 cells, folate and lipid levels were measured by ELISA and staining techniques, respectively. In addition, up to 482 amino acids and lipid metabolites were semi-quantified in SLC19A1-knockdown (KD) cells through ultra-high-performance liquid chromatography coupled with mass spectrometry. SNPs, rs1051266 and rs3788200, were significantly associated with the development of fatty liver for the single-marker allelic test. The minor alleles of these SNPs were associated with a 0.6/−1.67-fold decreased risk of developing MAFLD. When SLC19A1 was KD in THLE2 cells, intracellular folate content was four times lower than in wild-type cells. The lack of functional SLC19A1 provoked significant changes in the regulation of genes associated with lipid droplet accumulation within the cell and the onset of NAFLD. Metabolomic analyses showed a highly altered profile, where most of the species that accumulated in SLC19A1-KD-cells belong to the chemical groups of triacylglycerols, diacylglycerols, polyunsaturated fatty acids, and long chain, highly unsaturated cholesterol esters. In conclusion, the lack of SLC19A1 gene expression in hepatocytes affects the regulation of key genes for normal liver function, reduces intracellular folate levels, and impairs lipid metabolism, which entails lipid droplet accumulation in hepatocytes.
Which Epidemiological Characteristics Drive Decision Making in the Management of Patients with Vestibular Schwannoma?
Authors: Fík Zdeněk , Vlasák Aleš , Zvěřina Eduard , Sýba Jaroslav , Lazák Jan , Peterková Lenka , Koucký Vladimír , Betka Jan
Published: January 2023

The incidence of sporadic vestibular schwannoma has significantly increased over the past few decades. However, there is no method currently available to accurately predict the risk of subsequent tumor growth. The difference in the management of five patient groups has been evaluated: wait and scan, conversion to microsurgery, conversion to stereoradiotherapy, sterioradiotherapy, and microsurgery. In total, 463 patients with vestibular schwannoma have been consulted in our department from 2010 through 2016. Of the 250 patients initially indicated for observation, 32.4% were later indicated for active treatment. Younger patients were more frequently indicated for surgery (mean age 48 years) compared to older patients, who were more often indicated for stereoradiotherapy (mean age 62 years). Tumor growth was observed more often in patients under 60 years of age and in patients with tumors greater than 10 mm. In elderly patients, including those with larger tumors, a conservative approach is the optimal solution. If tumor growth occurs in the wait-and-scan strategy, it is still possible to continue with a conservative approach in some situations. The duration of follow-up scans is still a matter of debate, as tumors can begin to grow after 5 years from the initial diagnosis.
Two Ways of Targeting a CD19 Positive Relapse of Acute Lymphoblastic Leukaemia after Anti-CD19 CAR-T Cells
Authors: Grain Audrey , Ollier Jocelyn , Guillaume Thierry , Chevallier Patrice , Le Calvez Baptiste , Eveillard Marion , Clémenceau Béatrice
Published: January 2023

Background: Therapeutic options for CD19+ relapses after anti-CD19 CAR-T cells are still debated; second infusion of anti-CD19 CAR-T cells, therapeutic antibodies, or targeted therapies can be discussed. Here, we explore the immunophenotyping and lysis sensitivity of CD19+ ALL relapse after anti-CD19 CAR-T cells and propose different therapeutic options for such a high-risk disease. Methods: Cells from successive B-ALL relapses from one patient were collected. A broad immunophenotype analysis was performed. 51Cr cytotoxic assays, and long-term killing assays were conducted using T-cell effectors that are capable of cytotoxicity through three recognition pathways: antibody-dependent cell-mediated cytotoxicity (ADCC), anti-CD19 CAR-T, and TCR. Results: Previously targeted antigen expression, even if maintained, decreased in relapses, and new targetable antigens appeared. Cytotoxic assays showed that ALL relapses remained sensitive to lysis mediated either by ADCC, CAR-T, or TCR, even if the lysis kinetics were different depending on the effector used. We also identified an immunosuppressive monocytic population in the last relapse sample that may have led to low persistence of CAR-T. Conclusion: CD19+ relapses of ALL remain sensitive to cell lysis mediated by T-cell effectors. In case of ALL relapses after immunotherapy, a large immunophenotype will make new therapies possible for controlling such high risk ALL.
Spoken Word Recognition across Language Boundary: ERP Evidence of Prosodic Transfer Driven by Pitch
Authors: Zhang Juan , Meng Yaxuan , Wu Chenggang , Yuan Zhen
Published: January 2023

Extensive research has explored the perception of English lexical stress by Chinese EFL learners and tried to unveil the underlying mechanism of the prosodic transfer from a native tonal language to a non-native stress language. However, the role of the pitch as the shared cue by lexical stress and lexical tone during the transfer remains controversial when the segmental cue (i.e., reduced vowel) is absent. By employing event-related potential (ERP) measurements, the current study aimed to further investigate the role of the pitch during the prosodic transfer from L1 lexical tone to L2 lexical stress and the underlying neural responses. Two groups of adult Chinese EFL learners were compared, as both Mandarin and Cantonese are tonal languages with different levels of complexity. The results showed that Cantonese speakers relied more than Mandarin speakers on pitch cues, not only in their processing of English lexical stress but also in word recognition. Our findings are consistent with the arguments of Cue Weighting and attest to the influence of native tonal language experience on second language acquisition. The results may have implications on pedagogical methods that pitch could be an important clue in second language teaching.
Correlations among Psychological Resilience, Cognitive Fusion, and Depressed Emotions in Patients with Depression
Authors: Chen Ning , Xi Juzhe , Fan Xiwang
Published: January 2023

Background: More than 300 million people worldwide suffer from depression, which is a significant contributor to the global burden of disease. This study investigated the factors influencing psychological resilience and cognitive fusion in patients with depression and the relationships of psychological resilience and cognitive fusion with depression. Methods: This study enrolled 172 participants (65.8% of them were female). Psychological resilience, cognitive fusion, and depression were assessed with the psychological resilience scale, the cognitive fusion questionnaire, the Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), and Zung Self-rating Depression Scale (SDS), respectively. Furthermore, the relationships of psychological resilience and cognitive fusion with depression were investigated. Results: The psychological resilience and cognitive fusion scores of patients with depression varied significantly among different education levels, and HAMA, HAMD, and SDS scores were significantly negatively correlated with psychological resilience but positively correlated with cognitive fusion. Conclusions: Depression levels in patients with depression are closely related to psychological resilience and cognitive fusion. Therefore, anxiety and depression could be alleviated by improving the psychological resilience or reducing the cognitive fusion of patients with depression.
Uncertainty Assessment of Mean Radiant Temperature Estimation for Indoor Thermal Comfort Based on Clustering Analysis of Reduced-Input Surfaces
Authors: Kang Eunho , Lee Ruda , Yoon Jongho , Cho Heejin , Kim Dongsu
Published: January 2023

Mean radiant temperature (MRT) is important for indoor thermal comfort determination. Several good ways to practically obtain accurate MRT include measuring all indoor surface temperatures for MRT calculation or using a black globe thermometer. Still, it can be hard to apply in practice because using such experimental measurements increases the efforts of data management times and acquisition costs. In this regard, there is a practical advantage in reducing the number of measured surfaces by grouping similar surfaces rather than measuring all indoor surface temperatures individually to obtain MRT. However, since even those similar surfaces are not the same, it can lead to erroneous MRT estimation, which needs to be investigated. This study analyzes the uncertainty of MRT estimates by categorizing the surfaces with similar temperature behaviors to examine the risk of such inaccuracy. In this study, the input data required for the MRT calculation are generated using a measurement data-based simulation model, and the uncertainty of the MRT is quantified using the Monte Carlo method. As a result of the study, it is observed that excluding surfaces with similar temperatures for MRT estimation does not significantly affect the uncertainty. When the appropriate number of input surfaces is satisfied, its MRT shows a difference of less than 1% compared to the results calculated with all surfaces.
Comparisons of Radiofrequency Ablation, Microwave Ablation, and Irreversible Electroporation by Using Propensity Score Analysis for Early Stage Hepatocellular Carcinoma
Authors: Wada Takuya , Sugimoto Katsutoshi , Sakamaki Kentaro , Takahashi Hiroshi , Kakegawa Tatsuya , Tomita Yusuke , Abe Masakazu , Yoshimasu Yu , Takeuchi Hirohito , Itoi Takao
Published: January 2023

Background: Despite the diversity of thermal ablations, such as radiofrequency ablation (RFA) and microwave ablation (MWA), and non-thermal ablation, such as irreversible electroporation (IRE) cross-comparisons of multiple ablative modalities for hepatocellular carcinoma (HCC) treatment remain scarce. Thus, we investigated the therapeutic outcomes of different three ablation modalities in the treatment of early stage HCC. Methods: A total of 322 consecutive patients with 366 HCCs (mean tumor size ± standard deviation: 1.7 ± 0.9 cm) who underwent RFA (n = 216, 59.0%), MWA (n = 91, 28.3%), or IRE (n = 15, 4.7%) were included. Local tumor progression (LTP) rates for LTP were compared among the three modalities. Propensity score-matched analysis was used to reduce selection bias. Results: A significant difference in 2-year LTP rates between the IRE and RFA groups (IRE, 0.0% vs. RFA, 45.0%; p = 0.005) was found. There was no significant difference in 2-year LTP rates between the IRE and MWA groups (IRE, 0.0% vs. MWA, 25.0%; p = 0.103) as well as between the RFA and MWA groups (RFA, 18.2% vs. MWA, 20.6%; p = 0.586). Conclusion: IRE provides better local tumor control than RFA as a first-line therapeutic option for small perivascular HCC.
Characterizing the Ablative Effects of Histotripsy for Osteosarcoma: In Vivo Study in Dogs
Authors: Ruger Lauren N. , Hay Alayna N. , Vickers Elliana R. , Coutermarsh-Ott Sheryl L. , Gannon Jessica M. , Covell Hannah S. , Daniel Gregory B. , Laeseke Paul F. , Ziemlewicz Timothy J. , Kierski Katharine R. , Ciepluch Brittany J. , Vlaisavljevich Eli , Tuohy Joanne L.
Published: January 2023

Osteosarcoma (OS) is a malignant bone tumor treated by limb amputation or limb salvage surgeries and chemotherapy. Histotripsy is a non-thermal, non-invasive focused ultrasound therapy using controlled acoustic cavitation to mechanically disintegrate tissue. Recent ex vivo and in vivo pilot studies have demonstrated the ability of histotripsy for ablating OS but were limited in scope. This study expands on these initial findings to more fully characterize the effects of histotripsy for bone tumors, particularly in tumors with different compositions. A prototype 500 kHz histotripsy system was used to treat ten dogs with suspected OS at an intermediate treatment dose of 1000 pulses per location. One day after histotripsy, treated tumors were resected via limb amputation, and radiologic and histopathologic analyses were conducted to determine the effects of histotripsy for each patient. The results of this study demonstrated that histotripsy ablation is safe and feasible in canine patients with spontaneous OS, while offering new insights into the characteristics of the achieved ablation zone. More extensive tissue destruction was observed after histotripsy compared to that in previous reports, and radiographic changes in tumor size and contrast uptake following histotripsy were reported for the first time. Overall, this study significantly expands our understanding of histotripsy bone tumor ablation and informs future studies for this application.
CANTO-RT: One of the Largest Prospective Multicenter Cohort of Early Breast Cancer Patients Treated with Radiotherapy including Full DICOM RT Data
Authors: Sarrade Thomas , Allodji Rodrigue , Ghannam Youssef , Auzac Guillaume , Everhard Sibille , Kirova Youlia , Peignaux Karine , Guilbert Philippe , Pasquier David , Racadot Séverine , Bourgier Céline , Ducornet Sandrine , André Fabrice , De Vathaire Florent , Rivera Sofia
Published: January 2023

This article describes the methodology used and provides a characterization of the study population in CANTO-RT (CANcer TOxicities RadioTherapy). CANTO (NCT01993498) is a prospective clinical cohort study including patients with stage I-III BC from 26 French cancer centers. Patients matching all CANTO inclusion and exclusion criteria who received RT in one of the 10 top recruiting CANTO centers were selected. Individual full DICOM RT files were collected, pseudo-anonymized, structured and analyzed on the CANTO-RT/UNITRAD web platform. CANTO-RT included 3875 BC patients with a median follow-up of 64 months. Among the 3797 patients with unilateral RT, 3065 (80.4%) had breast-conserving surgery, and 2712 (71.5%) had sentinel node surgery. Tumor bed boost was delivered in 2658 patients (68.5%) and lymph node RT in 1356 patients (35%), including internal mammary chain in 844 patients (21.8%). Most patients (3691 (95.3%)) were treated with 3D conformal RT. Target volumes, organs at risk contours and dose/volume histograms were extracted after quality-control procedures. CANTO-RT is one of the largest early BC prospective cohorts with full individual clinical, biological, imaging and DICOM RT data available. It is a valuable resource for the identification and validation of clinical and dosimetric predictive factors of RT and multimodal treatment-related toxicities.
Autophagy as a Therapeutic Target for Chronic Kidney Disease and the Roles of TGF-β1 in Autophagy and Kidney Fibrosis
Authors: Ruby Miss , Gifford Cody C. , Pandey RamendraPati , Raj V. Samuel , Sabbisetti Venkata S. , Ajay Amrendra K.
Published: January 2023

Autophagy is a lysosomal protein degradation system that eliminates cytoplasmic components such as protein aggregates, damaged organelles, and even invading pathogens. Autophagy is an evolutionarily conserved homoeostatic strategy for cell survival in stressful conditions and has been linked to a variety of biological processes and disorders. It is vital for the homeostasis and survival of renal cells such as podocytes and tubular epithelial cells, as well as immune cells in the healthy kidney. Autophagy activation protects renal cells under stressed conditions, whereas autophagy deficiency increases the vulnerability of the kidney to injury, resulting in several aberrant processes that ultimately lead to renal failure. Renal fibrosis is a condition that, if chronic, will progress to end-stage kidney disease, which at this point is incurable. Chronic Kidney Disease (CKD) is linked to significant alterations in cell signaling such as the activation of the pleiotropic cytokine transforming growth factor-β1 (TGF-β1). While the expression of TGF-β1 can promote fibrogenesis, it can also activate autophagy, which suppresses renal tubulointerstitial fibrosis. Autophagy has a complex variety of impacts depending on the context, cell types, and pathological circumstances, and can be profibrotic or antifibrotic. Induction of autophagy in tubular cells, particularly in the proximal tubular epithelial cells (PTECs) protects cells against stresses such as proteinuria-induced apoptosis and ischemia-induced acute kidney injury (AKI), whereas the loss of autophagy in renal cells scores a significant increase in sensitivity to several renal diseases. In this review, we discuss new findings that emphasize the various functions of TGF-β1 in producing not just renal fibrosis but also the beneficial TGF-β1 signaling mechanisms in autophagy.
Efficacy of Liraglutide in Obesity in Children and Adolescents: Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Cornejo-Estrada Alejandra , Nieto-Rodríguez Carlos , León-Figueroa Darwin A. , Moreno-Ramos Emilly , Cabanillas-Ramirez Cielo , Barboza Joshuan J.
Published: January 2023

In the past few decades, childhood obesity has become a significant global health issue, impacting around 107.7 million children and adolescents globally. There is currently minimal usage of pharmacological therapies for childhood obesity in the pediatric population. This research assessed the efficacy of liraglutide in treating childhood and adolescent obesity. Until 20 October 2022, a systematic literature review was done utilizing PubMed, Scopus, Web of Science, and Embase databases. The search phrases “liraglutide”, “pediatric obesity”, “children”, and “adolescents” were utilized. Using the search method, a total of 185 articles were found. Three studies demonstrating liraglutide’s effectiveness in treating child and adolescent obesity were included. The selected research was done in the United States. As an intervention, liraglutide was administered to 296 participants at a maximal dosage of 3.0 mg. All examined trials were in phase 3. This comprehensive analysis revealed no clinically significant differences between liraglutide and body weight (kg; MD −2.62; 95%CI −6.35 to 1.12; p = 0.17) and body mass index (kg/m2; MD −0.80; 95%CI −2.33 to 0.73, p = 0.31). There was no evidence that liraglutide increased hypoglycemia episodes (RR 1.08; 95%CI 0.37 to 3.15; p = 0.79), or side consequences. However, it was shown that the medicine might help reduce BMI and weight combined with a healthy diet and regular exercise. A lifestyle change may have favorable consequences that will be assessed in the future for adjunctive therapy. PROSPERO database (CRD42022347472)
Impact of Thin Meconium on Delivery and Early Neonatal Outcomes
Authors: Schreiber Hanoch , Shilony Adi , Amrami Reut Batia , Cohen Gal , Markovitch Ofer , Biron-Shental Tal , Bauer-Rusek Sofia , Arnon Shmuel , Kovo Michal
Published: January 2023

Several reports regarding the effects of thin meconium on maternal and neonatal outcomes are contradictory. This study evaluated the risk factors and obstetrical outcomes during deliveries complicated with thin meconium. This retrospective cohort study included all women with a singleton pregnancy, who underwent trial of labor >24 weeks of gestation, in a single tertiary center, over a six-year period. Obstetrical, delivery, and neonatal outcomes were compared between deliveries with thin meconium (thin meconium group) to deliveries with clear amniotic fluid (control group). Included in the study were 31,536 deliveries. Among them 1946 (6.2%) were in the thin meconium group and 29,590 (93.8%) were controls. Meconium aspiration syndrome was diagnosed in eight neonates in the thin meconium group and in none of the controls (0.41%, p < 0.001). In multivariate logistic regression analysis, the following adverse outcomes were found to be independently associated with increased odds ratio (OR) for thin meconium: intrapartum fever (OR 1.37, 95% CI 1.1–1.7), instrumental delivery (OR 1.26, 95% CI 1.09–1.46), cesarean delivery for non-reassuring fetal heart rate (OR 2.0, 95% CI 1.68–2.46), and respiratory distress requiring mechanical ventilation (OR 2.06, 95% CI 1.19–3.56). Thin meconium was associated with adverse obstetrical, delivery, and neonatal outcomes that should receive extra neonatal care and alert the pediatrician.
Flow Characteristics and Hydraulic Lift of Coandă Effect-Based Pick-Up Method for Polymetallic Nodule
Authors: Jia Hao , Yang Jian , Su Xianghui , Wang Yapeng , Wu Kexin
Published: January 2023

The deep-sea mining vehicle is the main component of the undersea exploitation system, which gathers polymetallic nodules with its professionally designed seabed collector. The Coandă effect-based collecting method is an improved hydraulic method that forms an adverse pressure gradient over the nodules by performing wall jet flow over a rounded convex surface. In comparison to the circular cylinder surface, the effect of wall jet over the logarithmic spiral surface has a self-preserving nature, which can be advantageous to the nodule collecting. However, this effect on lift capability has seldom been studied before. In the present investigation, a reduced form modelling jet flows over logarithmic spiral surfaces was performed to study the flow characteristics and lift ability of the newly designed Coandă effect-based collector. The jet-half width has been optimized to study the influence of wall curvature on the growth rate. The lift ability was found to be stronger with larger jet exit velocity, local curvature, or non-dimensional jet slot height. The growth rate, which represents the width of the main jet flow, went up in proportion to the downstream distance. The lift capability of jet flow in logarithmical spiral of x/R = 1 is significantly better than that of x/R = 2/3.
Study of Particulate Fouling Inhibition Characteristics on a Novel Composite Coating
Authors: Wang Yuchen , Liu Zuodong , Feng Wei , Zhang Teng , Xing Weiwei
Published: January 2023

Particulate fouling is a common fouling in heat exchange equipment, it causes tube corrosion and increases flow resistance. Particulate fouling increases the hidden danger of equipment and requires high treatment costs. In this paper, a novel Ni−P−TiO2 composite coating is prepared on 316 stainless steel using electroless plating and the fouling inhibition characteristics of the novel composite coating are studied using a dynamic monitoring experimental system. The experimental results show that the fouling thermal resistance of the Ni−P−TiO2 composite coating is obviously lower than that of 316 stainless steel under the same working conditions. With the increase in cooling water velocity and inlet temperature, the surface fouling thermal resistance decreases, while, with the increase in particle concentration, the fouling thermal resistance increases. Based on DLVO theory, it is found that the surface energy of Ni−P−TiO2 composite coating is close to the best surface energy for inhibiting particulate fouling deposition, which can significantly inhibit particulate fouling deposition. Compared with the stainless-steel surface of a conventional plate heat exchanger, the Ni−P−TiO2 composite coating not only inhibits the accumulation of particulate fouling, but also reduces the adhesion strength of particulate fouling; additionally, the fouling is easier to strip off the heat exchange surface, which realizes the lasting and efficient fouling inhibition on the heat exchange surface. The research results can provide a data reference for the fouling inhibition design and daily efficient operation of heat exchangers.
Role of Persistent Slip Bands and Persistent Slip Markings in Fatigue Crack Initiation in Polycrystals
Authors: Polák Jaroslav
Published: January 2023

The cyclic plastic deformation of polycrystals leads to the inhomogeneous distribution of the cyclic plastic strain. The cyclic plastic strain is concentrated in thin bands, called persistent slip bands (PSBs). The dislocation structure of these bands generally differs from the matrix structure and is characterized by alternating dislocation-rich and dislocation-poor regions. The mechanisms of the dislocation motion in the PSBs and the formation of the point defects and their migration are quantitatively described. It is shown that, due to localized cyclic plastic straining in the PSBs, persistent slip markings (PSMs) are produced where the PSBs emerge on the surface. They typically consist of a central extrusion accompanied by one or two parallel intrusions. The deep intrusion is equivalent to the crack-like surface defect. The concentration of the cyclic strain in the tip of an intrusion leads to intragranular fatigue crack initiation. The mechanism of the early crack growth in the primary slip plane is proposed and discussed. Numerous PSMs are produced on the surface of the cyclically loaded materials. PSMs contribute to the formation of the surface relief, as well as the relief on the grain boundary. PSMs from one grain impinging the grain boundary are sufficient to create sharp relief on the grain boundary. Void-like defects weaken the grain boundary cohesion and extra material push both grains locally apart. The conditions necessary for the weakening of the grain boundary are enumerated and examples of grain boundary crack initiations are shown. The relevant parameters affecting grain boundary initiation are identified and discussed. The collected experimental evidence and analysis is mostly based on the papers published by the author and his colleagues in the Institute of Physics of Materials in Brno.
Stability and Elasticity of Quasi-Hexagonal Fullerene Monolayer from First-Principles Study
Authors: Shen Guichang , Li Linxian , Tang Shuai , Jin Jianfeng , Chen Xiao-Jia , Peng Qing
Published: January 2023

As a newly synthesized two-dimensional carbon material, the stability study of monolayer fullerene networks or quasi-hexagonal phase fullerenes (qhp-C60) is timely desirable. We have investigated the stabilities of qhp-C60, including thermal, structural, mechanical, and thermodynamic stabilities, as well as the bonding characteristics, ductility, and mechanical properties, via first-principles calculations. The results show that qhp-C60 is energetically, mechanically, and thermodynamically stable. The thermodynamic stability of qhp-C60 at 300 K and 600 K is verified. The bonding characteristics of qhp-C60 are analyzed from the bond length, and it has sp2 and sp3 hybridization. The Pugh ratio (B/G) and Poisson’s ratio (v) indicate similar ductility with graphite and graphene. We also found that qhp-C60 has the lowest hardness and the anisotropy of the material. In addition, the electronic characteristics, including electron localization function (ELF), crystal orbital Hamiltonian population (COHP), and density of states (DOS) at different temperatures, are analyzed to verify the thermal stability of the material. Our results might be helpful in the material design of qhp-C60-related applications.
New Data on the Poorly Known Jurassic Record of the Turtle Hylaeochelys (Thalassochelydia), Based on New Finds from Portugal
Authors: Pérez-García Adán , Camilo Bruno , Ortega Francisco
Published: January 2023

Hylaeochelys is the only thalassochelydian turtle identified in the Cretaceous record. A single Lower Cretaceous species is known, Hylaeochelys belli, identified in United Kingdom and Germany and defined in the first half of the 19th century. Less than a decade ago, the presence of Hylaeochelys in the Upper Jurassic was recognized through the find of a single partial shell from West-Central Portugal. It was attributed to a new species, Hylaeochelys kappa. Until now, no other Hylaeochelys specimen was known for either the Iberian Peninsula or the Jurassic record. Two new specimens attributable to Hylaeochelys, from two different Upper Jurassic outcrops of west-central Portugal, are presented here. Its systematic attribution is analyzed. Consequently, knowledge about the anatomy and intraspecific variability of Hylaeochelys kappa is increased.
Pylephlebitis: A Systematic Review on Etiology, Diagnosis, and Treatment of Infective Portal Vein Thrombosis
Authors: Fusaro Lisa , Di Bella Stefano , Martingano Paola , Crocè Lory Saveria , Giuffrè Mauro
Published: January 2023

Pylephlebitis, defined as infective thrombophlebitis of the portal vein, is a rare condition with an incidence of 0.37–2.7 cases per 100,000 person-years, which can virtually complicate any intra-abdominal or pelvic infections that develop within areas drained by the portal venous circulation. The current systematic review aimed to investigate the etiology behind pylephlebitis in terms of pathogens involved and causative infective processes, and to report the most common symptoms at clinical presentation. We included 220 individuals derived from published cases between 1971 and 2022. Of these, 155 (70.5%) were male with a median age of 50 years. There were 27 (12.3%) patients under 18 years of age, 6 (2.7%) individuals younger than one year, and the youngest reported case was only 20 days old. The most frequently reported symptoms on admission were fever (75.5%) and abdominal pain (66.4%), with diverticulitis (26.5%) and acute appendicitis (22%) being the two most common causes. Pylephlebitis was caused by a single pathogen in 94 (42.8%) cases and polymicrobial in 60 (27.2%) cases. However, the responsible pathogen was not identified or not reported in 30% of the included patients. The most frequently isolated bacteria were Escherichia coli (25%), Bacteroides spp. (17%), and Streptococcus spp. (15%). The treatment of pylephlebitis consists initially of broad-spectrum antibiotics that should be tailored upon bacterial identification and continued for at least four to six weeks after symptom presentation. There is no recommendation for prescribing anticoagulants to all patients with pylephlebitis. However, they should be administered in patients with thrombosis progression on repeat imaging or persistent fever despite proper antibiotic therapy to increase the rates of thrombus resolution or decrease the overall mortality, which is approximately 14%.
Biomarkers of Sepsis
Authors: Agnello Luisa , Ciaccio Marcello
Published: January 2023

Sepsis is a highly complex disease caused by a deregulated host’s response to infection [...]
Histological Changes in Portal Cavernoma Cholangiopathy
Authors: Rastogi Archana , Bihari Chhagan , Thapar Shalini L. , Bhatia Vikram
Published: January 2023

Introduction: Portal cavernoma cholangiopathy (PCC)’ refers to abnormalities of the extrahepatic and intrahepatic bile ducts in patients with portal hypertension. Although there is data on clinical and imaging aspects of PCC, the description of liver pathology has been strikingly deficient. The purpose of this study was to examine the histopathological characteristics of PCC. Patients and Methods: A retrospective study of patients clinically diagnosed with extrahepatic portal vein obstruction (EHPVO) with portal cavernoma cholangiopathy, was conducted. Vascular anatomy was characterized by computerized tomographic angiography, and endoscopic retrograde cholangiography (ERC) and magnetic resonance cholangiography (MRC) were used to characterize the biliary anatomy. Histological features were analyzed by two hepatopathologists in a blinded manner, with mutual discussion to resolve any discrepancies. Results: A total of 50 patients with portal cavernoma cholangiopathy were included in the study. The mean age of the patients was 26.2 ± 11.6 years. Radiologically, bilobar intrahepatic biliary dilatation was seen in 98% with common bile duct abnormality in 100% of patients, along with extrinsic ductal impressions in 77 % of cases. Liver tests were deranged total bilirubin 1.5 mg/dL (IQR 0.8–2.4) and alkaline phosphatase 109.5 IU/L (IQR 70–193). Histologically; dilated multiple portal venous channels (72%), hepatic artery thickening (70%). The presence of aberrant vascular channels around portal tracts (54%), elastosis of portal veins (50%), and bile ductular reaction in (44%) were the other prominent findings. A 12% of cases show focal thin bridges. Advanced fibrosis was not seen in any of the cases. One-fourth of the cases showed concomitant minimal to mild hepatocyte steatosis. Conclusions: Histologically, intrahepatic portal vein and portal tract abnormalities were noted in cases with portal cavernoma cholangiopathy, associated with mild derangement of liver tests.