bluuebunny/crossref_metadata_2025 huggingface dataset:
PENINGKATAN PENGGUNAAN BUKU KIA SEBAGAI MEDIA PENYULUHAN KADER UNTUK MENCEGAH STUNTING
Authors: Rinayati Rinayati , Rahmat Basuki , Harsono Harsono , Iswandari Hargianti Dini
Published: February 2025

Kader PKK POKJA IV RW I Kelurahan Sumurboto Kecamatan Banyumanik Kota Semarang Propinsi Jawa Tengah merupakan garda terdepan dalam melakukan sosialisasi untuk merangkul dan mengajak masyarakat dalam  memerangi kejadian stunting diwilayahnya. tujuan Pelaksanaan kegiatan PKM ini menitikberatkan peningkatan penggunaan buku KIA sebagai media penyuluhan oleh kader dalam rangka pencegahan stunting.Metode pelaksanaan diawali dengan perijinan kepada kelurahan dan RW, penggalian dan pengumpulan data di lapangan, perancangan dan sosialisasi. solusi yang ditawarkan kepada mitra yaitu sosialisasi buku KIA dan penggunaan buku KIA sebagai media penyuluhan di meja empat posyandu, dan praktik  langsung penggunaan buku KIA sebagai media penyuluhan.Hasil Pengetahuan dan keterampilan kader Pokja IV  dalam memberikan penyuluhan kepada ibu balita di RW 1 Kelurahan Sumurboto Kecamatan Banyumanik Kota Semarang Propinsi Jawa Tengah meningkat dari 93 % menjadi 100%,  kader  memahami bahwa buku KIA tidak hanya dapat digunakan sebagai alat pencatatan hasil pemeriksaan sejak ibu hamil bersalin nifas menyusui sampai anak balita saja namun juga dapat digunakan sebagai media penyuluhan yang sangat lengkap karena dalam buku KIA terdapat informasi kesehatan buat ibu dan anak  pada umumnya dan upaya pencegahan stunting pada khususnya. Tim PKM telah berhasil  melaksanakan upaya Pendampingan kader pokja IV dalam penggunaan buku KIA sebagai media Penyuluhan dalam rangka penurunan kejadian stunting.
PKM MANFAAT PEMBERIAN BABY GYM UNTUK STIMULASI PERKEMBANGAN ANAK DI RW 06 KELURAHAN KRAPYAK
Authors: Agustiningsih Luhur Sesanti , Mahardika Putri Sima Asmara Dewa Marya , Wulandari Ovika Dyah
Published: February 2025

Bayi merupakan dasar dari awal kehidupan manusia dimana pertumbuhan dan perkembangan menjadi faktor utama untuk menuju tahapan berikutnya.Pada masa ini sangat bergantung dari orang tua dalam hal pemenuhan kebutuhan dasar untuk tumbuh kembangnya.Dalam merangsang pertumbuhan dan perkembangan bayi dibutuhkan stimulasi.Salah satu cara merangsang pertumbuhan dan perkembangan adalah dengan pemberian Baby gym. Tujuan dari pemberian baby gym adalah untuk mengetahui  pengaruh motorik halus dan motorik kasar pada balita yang ada di Posyandu RW 06 Kelurahan Krapyak, supaya balita yang ada di Posyandu RW 06 Kelurahan Krapyak dapat tumbuh sesuai dengan usianya. Metode yang disampaikan kepada Kader Posyandu berupa pelatihan bagaimana cara memberikan Baby Gym yang tepat untuk stimulasi perkembangan anak, agar kader posyandu yang ada di Rw 06 dapat memberikan penyuluhan dan pelatihan kembali kepada ibu yang memiliki balita di Rw 06 Kelurahan Krapyak. Untuk membantu dalam hal pemahaman mengenai manfaat baby gym, maka dilakukan kegiatan berupa pemberian materi, diskusi dan penerapan baby gym. Setelah diberikan pelatihan dan pendampingan kepada kader posyandu di Rw 06 Kelurahan Krapyak di dapatkan hasil bahwa kader posyandu memahami bagaimana cara yang benar dan tepat tentang pelaksanaan baby gym untuk perkembangan anak.
GAME GO-SIBA (SIAGA BENCANA) SEBAGAI MEDIA EDUKASI KESIAPSIAGAAN BENCANA PADA REMAJA
Authors: Lestari Sri , Afandi Alfan , Wibowo Agung , Widyawati Sigit Ambar
Published: February 2025

Indonesia dapat dikatakan memiliki potensi bencana yang lengkap, mulai dari bencana alam hingga bencana sosial. Kabupaten Semarang khususnya kota Ungaran memiliki beberapa gedung bertingkat yang rentan apabila terjadi bencana. Salah satu gedung dengan intensitas kegiatan tinggi dan perlu menjadi salah satu fokus dalam peningkatan kesiapsiagaan adalah SMA Negeri 2 Ungaran. Dari hasil observasi ditemukan bahwa 7 dari 10 anak tidak tahu cara atau prosedur penanggulangan jika terjadi bencana. Pada pengabdian masyarakat ini akan dilakukan peningkatan kesiapsiagaan terhadap bencana melalui media edukasi Game Go-SIBA berbasis digitalisasi sebagai upaya pengurangan risiko bencana pada remaja. Diharapkan hasil dari kegiatan ini para siswa dapat meningkatkan pengetahuan terkait kesiapsiagaan dalam menghadapi bencana sehingga mengurangi potensi risiko bencana serta mampu melakukan simulasi kesiapsiagaan bencana. Metode pelaksanaan kegiatan yang dilaksanakan meliputi tahap persiapan, tahap pelaksanaan, dan evaluasi. Sasaran dalam kegiatan PKM ini meliputi asaran primer yaitu siswa-siswi SMA Negeri 2 Ungaran dan sasaran sekunder yaitu tokoh yang berpengaruh terhadap siswa di sekolah. Hasil dari kegiatan ini memberikan pengaruh positif pada pengetahuan remaja yang ada di SMA Negeri 2 Ungaran serta memberikan peningkatan pengetahuan dan sikap remaja dalam kesiapsiagaan dalam menghadapi bencana sehingga mengurangi potensi risiko bencana.
PEMBERDAYAAN IBU PKK DALAM MENGEDUKASI PEMERIKSAAN RADIOGRAFI GENU UNTUK MENDETEKSI KASUS OSTEOARTHRITIS KABUPATEN KENDAL PROVINSI JAWA TENGAH
Authors: Prayoga Aryadiva Nugrahaning , Sulistyowati Indah
Published: February 2025

Osteoarthritis adalah suatu kondisi sendi degeneratif. Hal ini menyebabkan rasa sakit, bengkak dan kaku, sehingga mempengaruhi kemampuan seseorang untuk bergerak bebas. Hal ini paling sering terjadi pada lutut, pinggul, tulang belakang dan tangan. Banyak faktor yang dapat berkontribusi terhadap berkembangnya osteoarthritis. Prosedur  radiografi  genu adalah  pemeriksaan radiologi non kontras pada genu menggunakan sinar-x untuk mengevaluasi  kelainan anatomi yang ada di genu. Proyeksi  yang  dapat  digunakan  dalam  menegakkan klinis osteoarthritis pada genu adalah proyeksi Antero-Posterior  bilateral weight bearing. Pemeriksaan radiografi genu dengan proyeksi bilateral weight bearing direkomendasikan  untuk  kasus osteoarthritis. Metode yang dilakukan dalam kegiatan PKM ini adalah melakukan pendampingan dan pemberdayaan Ibu PKK dalam mengedukasi Masyarakat agar mengetahui akan pentingnya pemeriksaan radiografi Genu pada kasus OA dan mau melakukan pemeriksaan tersebut agar diagnose tepat dan mendapat pengobatan atau terapi yang sesuai. Adapun tujuan yang ingin dicapai dalam kegiatan ini adalah menambah wawasan Masyarakat khususnya PKK Kecamatan Pegandon Kab. Kendal serta memberdayakan ibu PKK untuk menjelaskan Peran Pemeriksaan Radiografi Genu Untuk Mendeteksi Kasus Osteoarthritis ( OA ) sehingga meningkatkan kesadaran untuk melakukan screening pemeriksaan radiografi Genu dengan kasus Osteoarthrtitis ( OA ).  Dari hasil kegiatan PkM yang sudah dilaksanakan oleh tim pengabdi tentang pemeriksaan Radiografi Genu untuk mendeteksi kasus Osteoarthritis (OA) maka simpulan yang diproleh ialah terdapat peningkatan pengetahuan Masyarakat tentang Osteoarthritis (OA), peningkatan pengetahuan tentang manfaat pemeriksaan dan pengetahuan tentang prosedur sebesar 94%. Serta terdapat peningkatan kesadaran untuk melakukan pemeriksaan Radiografi Genu untuk mendeteksi kasus Osteoarthritis (OA) sebesar 97%.
Peer relationships and leisure time in adolescence. Module 09
Authors:   HoltIS Association
Published: February 2025

The Module ”Peer relationships and leisure time in adolescence” offers participants an understanding of the importance of engaging with and learning about teenagers' peer influences and leisure activities. Parents are encouraged to understand, become aware of, and, most importantly, accept these differences to improve their relationship with teenagers at home. With greater wisdom, parents may also discover new strategies to address the challenges that inherently arise during this stage of development. In the first part of the module, discussions will centre on: the passions of parents versus those of teenagers, social, economic, educational, and cultural differences reflected in teenagers' leisure activities, the role of parents as primary role models for their children. how parental actions and activities influence the future of their children. The second part of the module will cover topics such as: the importance of money in teenagers' lives, seasonal jobs as exercises in responsibility for teenagers, factors leading teenagers to associate with inappropriate peer groups, parents' involvement in monitoring teenagers' peer circles, understanding teenagers' dress codes and fashion choices as a challenge for parents. The module includes brainstorming exercises and hands-on activities to enhance understanding and practical application. This module is part of the materials dedicated to the training of parental educators.
How to stay calm in stressful situations. Module 02
Authors:   Asociatia Holtis, Association HoltIS
Published: February 2025

The session "How to stay calm in stressful situations" offers a comprehensive overview of stress and anger. Stress is a normal part of life and parenting, and reducing it helps us gain more control over our lives. Similarly, accepting anger as a normal emotion and understanding the factors that trigger it supports personal planning for holistic emotion management. The theoretical elements presented aim to help participants discover, understand, and recognize the various aspects of stress and anger, as well as identify their own factors contributing to these emotional states. During this session, participants will also be introduced to different methods for managing stress and anger.

These practical techniques are designed to quickly reduce stress or anger and maintain self-control. By implementing these techniques, parents will not only improve their own quality of life but also that of their children, exposing them to the elements necessary for healthy emotional management. At the end of the session, the parental educator will ask parents to develop a Personal Anger Management Plan and encourage them to consult the Parent's Brochure on the Anger Management Plan (AMP).
How to Communicate Effectively with Your Child. Module 03
Authors:   Asociatia Holtis, Association HoltIS
Published: February 2025

The session "How to Communicate Effectively with Your Child" provides an in-depth exploration of various methods for effective and productive communication, thereby promoting best practices in relationships with others and with children. During this session, parents will explore the theoretical elements of interpersonal communication and discuss the three key components: verbal, paraverbal, and visual. Another essential element of effective communication that they will identify is active listening.

To reflect on their own communication style and apply the new elements introduced in the session, the parental educator will encourage parents to participate in activities designed to improve active listening skills and implement "I" messages. This will be achieved through the application of various methods that lead to motivational and balanced communication between parent and child. At the end of the session, the parental educator will ask parents to practice positive interpersonal communication skills with both their children and the adults in their lives.

This module is part of the materials dedicated to the training of parental educators.
How to be reliable partner for your child. Module 04
Authors:   Asociatia Holtis
Published: February 2025

The session "How to be reliable partner for your child" takes an integrated approach to the civic status of children at different stages of childhood within the Romanian state, emphasizing the importance of children’s involvement and participation in decisions and activities that concern them. During this session, parents will learn about children’s rights and reflect on the significance of their child’s active participation in activities and decisions that affect them.
In the first part of the session, the parental educator will present the different categories of children’s rights, such as the right to protection, the right to development, and the right to participation. Parents will explore the basic principles of participation and factors that contribute to building a positive parent-child relationship. In the second part of the session, they will discover various methods for applying theoretical elements and learn to differentiate between genuine and false participation using Roger Hart’s ladder of participation. This module is part of the materials dedicated to the training of parental educators.
How to stay calm in stressful situations. Module 02
Authors:   HoltIS Association
Published: February 2025

The session "How to stay calm in stressful situations" offers a comprehensive overview of stress and anger. Stress is a normal part of life and parenting, and reducing it helps us gain more control over our lives. Similarly, accepting anger as a normal emotion and understanding the factors that trigger it supports personal planning for holistic emotion management. The theoretical elements presented aim to help participants discover, understand, and recognize the various aspects of stress and anger, as well as identify their own factors contributing to these emotional states. During this session, participants will also be introduced to different methods for managing stress and anger. These practical techniques are designed to quickly reduce stress or anger and maintain self-control. By implementing these techniques, parents will not only improve their own quality of life but also that of their children, exposing them to the elements necessary for healthy emotional management. At the end of the session, the parental educator will ask parents to develop a Personal Anger Management Plan and encourage them to consult the Parent's Brochure on the Anger Management Plan (AMP). This module is part of the materials dedicated to the training of parental educators.
Phages as potential life-saving therapeutic option in the treatment of multidrug-resistant urinary tract infections
Authors: Zalewska-Piątek Beata , Nagórka Michalina
Published: February 2025

Urinary tract infections (UTIs) are among the most common bacterial infections worldwide and increasing antimicrobial resistance (AMR) challenges conventional antibiotic treatments. Phage therapy (PT) has emerged as a promising alternative due to its specificity, safety and efficacy against multidrug-resistant (MDR) pathogens causing infectious diseases. PT demonstrates significant potential in treating chronic and recurrent UTIs, also including catheter-associated infection by reducing bacterial biofilms, delaying catheter blockage, and enhancing antibiotic efficacy when used in combination. Clinical trials and case studies have reported high rates of bacterial eradication and symptom improvement with minimal side effects. Although endotoxin release and immune activation during treatment should continue to be investigated. The aim of this review is to present issues related to the use of phages in the treatment of UTIs of various etiological origins in selected patients, including those with comorbidities, taking into account the legal regulations, safety and effectiveness of this experimental therapy. The growing prevalence of MDR uropathogens highlights the urgent need for alternative therapies, such as those based on phages in order to treat antibiotic-resistant infections and improve patient outcomes. Despite the great potential of PT, its clinical implementation and use of phages as a routine treatment for bacterial infections requires rigorous trials, standardized production protocols and regulatory advancements.
Perspectives of older people toward Thai high-speed rail promotion using the theory of planned behavior and the unified theory of acceptance and use of technology
Authors: Watcharamaisakul Fareeda , Phojaem Thanakorn , Sum Sonita , Champahom Thanapong , Jomnonkwao Sajjakaj , Wisutwattanasak Panuwat , Dangbut Adisorn , Ratanavaraha Vatanavongs
Published: February 2025

Today, the population growth rate in Thailand is very slow. In particular, the number of older people in Thailand is notably increasing. Many members of this group are reluctant to accept or use new technology. The government is formulating a support plan for a high-speed rail (HSR) system to develop the public transportation system to support better livelihood and reduce traffic problems, which may affect the use intent of older people. The factors that influence HSR use will support social coherence and help older people to adapt to and cope with newly developed technology in the future. This study aims to develop a perspective model of the influence of HSR use among older people by applying the theory of planned behavior (TPB) combined with the unified theory of acceptance and use of technology (UTAUT). Data were collected through a questionnaire survey on 3,200 people older than 60 in four regions in Thailand. Analysis was conducted using the structural equation model. The result indicated that all factors of TPB and UTAUT significantly influenced the behavioral intention of older people to use HSR. The factor with the largest influence was the attitude toward technology use, followed by subjective norms and facilitating conditions. Moreover, performance and effort expectancies play statistically significant roles in the attitude toward technology use.
Novel gene manipulation approaches to unlock the existing bottlenecks of CAR-NK cell therapy
Authors: Dehghan Fatemeh , Metanat Yekta , Askarizadeh Mandana , Ahmadi Ehsan , Moradi Vahid
Published: February 2025

Currently, CAR-T cell therapy is known as an efficacious treatment for patients with relapsed/refractory hematologic malignancies. Nonetheless, this method faces several bottlenecks, including low efficacy for solid tumors, lethal adverse effects, high cost of autologous products, and the risk of GvHD in allogeneic settings. As a potential alternative, CAR-NK cell therapy can overcome most of the limitations of CAR-T cell therapy and provide an off-the-shelf, safer, and more affordable product. Although published results from preclinical and clinical studies with CAR-NK cells are promising, several bottlenecks must be unlocked to maximize the effectiveness of CAR-NK cell therapy. These bottlenecks include low in vivo persistence, low trafficking into tumor sites, modest efficacy in solid tumors, and sensitivity to immunosuppressive tumor microenvironment. In recent years, advances in gene manipulation tools and strategies have laid the groundwork to overcome the current bottlenecks of CAR-NK cell therapy. This review will introduce the existing gene manipulation tools and discuss their advantages and disadvantages. We will also explore how these tools can enhance CAR-NK cell therapy’s safety and efficacy.
Current and future therapeutic options for chronic hepatitis D virus infection
Authors: Pisaturo Mariantonietta , Russo Antonio , Grimaldi Pierantonio , Martini Salvatore , Coppola Nicola
Published: February 2025

In the last few years there have been innovations in HDV therapy which have brought new excitement in the scientific community also considering the few therapeutic opportunities. Recently, new molecular targets have been identified, both in monotherapy and in combination with peginterferon alpha (PegIFNα). Evaluating this review of the literature of the last ten years, HDV-related chronic hepatitis seems to have become a potentially curable disease, a statement that was unthinkable a few years ago. There are old and new weapons at our disposal. The old weapons are PegIFNα and recently PegIFN-lambda (PegIFNλ). PegIFNα, for which there are more data, appears to be an excellent combination regimen, if not contraindicated, both for Bulevirtide (BLV), data supported by important clinical trials and real-world studies, and probably for lonarfanib, although in the latter case the results are not yet definitive as the studies are fewer. However, data on long-term follow-up are needed.
Discovery of amino acid substitutions in penicillin-binding proteins associated with adaptation to D-Ala-D-Lac in vancomycin-resistant Enterococcus faecalis
Authors: Caglayan Nese , Sancak Banu , Kanlidere Zeynep , Kocagoz Tanil
Published: February 2025

The bacterial cell wall, essential for structural integrity, is synthesized with penicillin-binding proteins (PBPs). Vancomycin-resistant enterococci (VRE) evades vancomycin by replacing D-Ala-D-Ala in their cell wall precursors with D-Ala-D-Lac, reducing the drug’s effectiveness. However, how PBPs-which typically use D-Ala-D-Ala as a substrate-adapt to recognize D-Ala-D-Lac remains unclear. Here, we performed Sanger sequencing and alignment of PBP genes from both vancomycin-susceptible and -resistant E. faecalis strains to identify mutations, following amplification by PCR. We then applied homology modeling to assess structural impacts of these changes on PBPs and conducted docking studies to investigate ligand-binding interactions. For the first time, we identified specific adaptations in certain VRE PBPs that may facilitate the D-Ala-D-Lac utilization. We found that PBP1B, PBP2A, PBP3 showed changes, while PBP1A, PBP2B and PBP4 remained unchanged. Notably, a threonine-to-asparagine substitution at location 491 in PBP1B leads to a shift in substrate preference from D-Ala-D-Ala to D-Ala-D-Lac. Similar structural changes in PBP3 suggest that the presence of changed and unchanged PBPs within the same classes suggests compensatory interactions, indicating a teamwork among multiple PBPs. These insights into PBPs provide a deeper understanding of D-Ala-D-Lac utilization in VRE, may be used to develop new therapeutic agents to combat vancomycin resistance.
SHASI-ML: a machine learning-based approach for immunogenicity prediction in Salmonella vaccine development
Authors: Spiga Ottavia , Visibelli Anna , Pettini Francesco , Roncaglia Bianca , Santucci Annalisa
Published: February 2025

Introduction

Accurate prediction of immunogenic proteins is crucial for vaccine development and understanding host-pathogen interactions in bacterial diseases, particularly for Salmonella infections which remain a significant global health challenge.

Methods

We developed SHASI-ML, a machine learning-based framework for predicting immunogenic proteins in Salmonella species. The model was trained and validated using a curated dataset of experimentally verified immunogenic and non-immunogenic proteins. Three distinct feature groups were extracted from protein sequences: global properties, sequence-derived features, and structural information. The Extreme Gradient Boosting (XGBoost) algorithm was employed for model development and optimization.

Results

SHASI-ML demonstrated robust performance in identifying bacterial immunogens, achieving 89.3% precision and 91.2% specificity. When applied to the Salmonella enterica serovar Typhimurium proteome, the model identified 292 novel immunogenic protein candidates. Global properties emerged as the most influential feature group in prediction accuracy, followed by structural and sequence information. The model showed superior recall and F1-scores compared to existing computational approaches.

Discussion

These findings establish SHASI-ML as an efficient computational tool for prioritizing immunogenic candidates in Salmonella vaccine development. By streamlining the identification of vaccine candidates early in the development process, this approach significantly reduces experimental burden and associated costs. The methodology can be applied to guide and optimize both research and industrial-scale production of Salmonella vaccines, potentially accelerating the development of more effective immunization strategies.
Case Report: A minimally disruptive technique for the management of frozen leads
Authors: Chang Su-Huan , Lin Kuan-You , Yu Chih-Chieh
Published: February 2025

During pacemaker generator replacement, difficulties may arise with the set screw not being properly engaged, a situation referred as a “frozen lead”. We reported a case of an 88-year-old woman with a 15-year-old generator and increasing impedance of the right atrial lead. The disruption of the silicone plug and removal of the hidden metal ring facilitated successful disconnection of the generator without damaging the lead. Postoperative assessments demonstrated normalized right atrial lead impedance and stable parameters at follow-up. This case highlights the effectiveness of a minimally invasive approach to managing frozen leads, providing valuable insights in similar clinical scenarios.
The relationship between water production rate and resistivity in sand-based porous materials under two-phase fluid flow and its application
Authors: Xie Weibiao , Yin Qiuli , Dai Xueping , Fan Yang , Zhang Pan
Published: February 2025

Accurately predicting the water production rate of multiple-phase fluid flows through porous rock is important for many engineering and geological applications. Taking into account irreducible water and capillary tortuosity, the equivalent rock element model from previous studies has been improved. Based on the improved capillary equivalent rock element model, this study proposes a relationship model between the water production rate in two-phase fluid systems and the resistivity index. The relationship model is verified using rock samples, and the result shows that the water production rate calculated by the new model closely matches experimental values, improving parameter calculation accuracy. In addition, applications of the new model to well logging data show that the calculated water production rate is consistent with the actual production situation. This approach is more efficient and accurate in reservoir evaluation. The new model provides a new idea for studying the seepage characteristics of rocks with multiple-phase fluids.
A cooperative search algorithm-based flood forecasting framework: application across diverse Chinese catchments
Authors: Yang Jinhai , Wen Lei , Guo Junliang , Chen Yiru , Zhu Yongchen , Wang Yun , Ma Meihong
Published: February 2025

Flood forecasting is crucial for disaster mitigation, particularly in regions prone to flash floods. This study introduces a novel flood forecasting framework by coupling the Geomorphological Instantaneous Unit Hydrograph (GIUH) with the Xinanjiang model and optimizing parameters using the Cooperation Search Algorithm (CSA). Applied across six diverse Chinese catchments, the framework significantly improved computational efficiency and accuracy. Key findings demonstrate that: 1) CSA achieved high Nash-Sutcliffe Efficiency (NSE >0.9) with only 16 optimization trials on average, outperforming the SCE-UA algorithms; 2) The model performed exceptionally in data-sparse regions, achieving NSE values >0.9 even with minimal datasets; and 3) Enhanced runoff routing via GIUH enabled accurate simulation of extreme rainfall events. These results highlight the framework’s potential for operational flood forecasting and disaster management globally. Future research will expand validation datasets and explore applications across varied hydrological and climatic conditions.
A systematic review of the utility of assistive technologies for SEND students in schools
Authors: Mukhtarkyzy Kaussar , Smagulova Laura , Tokzhigitova Ainur , Serikbayeva Nurgul , Sayakov Olzhas , Turkmenbayev Asset , Assilbayeva Rakhila
Published: February 2025

The systematic review investigates the effect of various educational technologies on the learning outcomes of diverse student populations, particularly focusing on assistive technology interventions for students with disabilities. The comprehensive analysis covers literature from 2012 to 2023. The study highlights the potential of AR and assistive technologies in fostering inclusive and engaging learning environments. Despite positive findings, the review emphasizes the imperative for further research to refine the implementation of these technologies and enhance their effectiveness. The systematic review of five databases provides crucial insights into the effectiveness of various assistive technologies. Mobile devices, iPads, and AR interventions emerge as frequently utilized tools. Research activity peaked in 2013 and 2018 and subsequently declined. Twelve studies focus on Autism Spectrum Disorder and emphasize the prioritization of ASD in assistive technology interventions. The research highlights the importance of adopting a holistic perspective on educational inclusion, emphasizing collaborative efforts among teachers, diverse teaching methods, and technology integration. Despite the promise shown by assistive technologies, the review acknowledges their limitations and advocates for ongoing research and innovation to refine their application across diverse educational contexts. The findings stress the importance of a nuanced interpretation of evidence, considering the challenges posed by the limited number of eligible studies. The review calls for careful consideration of future research directions to bolster the comprehensiveness and reliability of evidence synthesis in assistive technology interventions for students with disabilities.
A Multivariate prediction model for amlodipine therapeutic efficacy in pediatric primary hypertension
Authors: Lin Yao , Wang Hui , Li Yaqi , Liu Yang , Liu Yanyan , Zhang Hongwei , Deng Yanjun , Shi Lin
Published: February 2025

Background

There are currently no biomarker-based prediction models for amlodipine therapeutic efficacy in pediatric hypertension. This study aimed to identify potential biomarkers and establish a biomarker-based model for predicting amlodipine therapeutic efficacy in pediatric primary hypertension (PH).

Methods

From January 2022 to December 2023, 165 children and adolescents with PH prescribed amlodipine were recruited at our department for a prospective observational study. Patients were grouped into Responders and Non-responders after one month treatment. The baseline data in the two groups were analyzed to identify variables associated with amlodipine treatment responsiveness; furthermore, a nomogram prediction model was established based on those potential predictors derived from multivariate regression analysis. This model’s discrimination and calibration were evaluated by a series of statistical methods and internal validation was done using the bootstrap sampling method (1000 resamples).

Results

Eighty-nine patients responded to amlodipine while 76 did not. After statistical adjustment, 4 variables were found to be independently associated with therapeutic efficacy, including hyperinsulinemia (OR = 3.000, 95% CI: 1.409-6.386, p  = 0.004), insulin resistance (OR = 2.354, 95% CI: 1.032-5.370, p = 0.042), the baseline plasma Endothelin-1 level (OR = 0.627, 95% CI: 0.532-0.740, p < 0.001) and amlodipine dosages (OR = 1.743, 95% CI: 1.400-2.169, p <0.001). Compared to the baseline model, the full model with the four variables had a good calibration with an area under the curve (AUC) of 0.967 (95% CI: 0.945-0.990), yielding a sensitivity and a specificity of 91.0% and 92.1%, respectively; the clinical decision curve showed a positive net benefit. Additionally, a nomogram model was established based on the four variables and evaluated by bootstrap internal validation with the c-statistic of 0.865 and the calibration curve being close to the ideal line (p > 0.05).

Conclusion

A nomogram model with high predictive value for amlodipine therapeutic efficacy in pediatric PH was established. This model may be potentially applied to guide the selection of amlodipine for the treatment of pediatric PH.
Effectiveness of ertugliflozin during Ramadan fasting in patients with type 2 diabetes mellitus: a real-world study (ErtuRamadan study)
Authors: Pathan Md Faruque , Akter Nazma , Mustari Marufa , Saifuddin M. , Sharifuzzaman Mirza , Rahman Mohammad Motiur , Ripon Mohammed , Mohiuddin S. M. , Kamrul-Hasan A. B. M. , Hannan Mohammad Abdul , Alam Muhammad Shah , Mahjabeen Samira , Afsana Faria , Bakar Muhammed Abu , Haq Tahniyah , Ahammed Afsar , Talukder Samir Kumar , Sarkar Sourav , Selim Shahjada
Published: February 2025

Background

Management of type 2 diabetes mellitus (T2DM) during Ramadan fasting presents unique challenges due to prolonged fasting periods, irregular meal schedules, and altered medication timing, potentially impacting glycemic control. Ertugliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, has been shown to improve glycemic control in T2DM effectively. However, the effectiveness of ertugliflozin during Ramadan fasting, a period with unique glycemic challenges, has not been studied extensively.

Methods

This study was a multicenter, real-life experience study involving 1373 adult patients with known T2DM for at least one year, an HbA1c level of less than 10%, and who intended to fast during Ramadan. Participants were divided into two groups: the Ertu group (n=703), consisting of patients who had been on a stable dose of ertugliflozin for at least three months before Ramadan, and the non-Ertu group (n=670), which included patients receiving other oral antihyperglycemic drugs (OADs) except ertugliflozin. Patients attended a baseline visit one month before the first day of Ramadan and a follow-up visit within one month after the last day of Ramadan. Both visits included history taking, physical examinations, and laboratory tests. The primary endpoints were changes in HbA1c levels, body weight, body mass index (BMI), and the incidence of hypoglycemia during Ramadan fasting.

Results

The mean age of the study participants was 50.37 ± 11.14 (SD) years, with 40.6% male and 58.7% female. Patients receiving ertugliflozin showed significant reduction in HbA1C (-0.65 ± 0.67% vs. -0.22 ± 0.64%, p<0.001), body weight (-1.24 ± 2.58 kg vs. -0.36 ± 3.41 kg, p<0.001), and BMI (-0.48 ± 1.03 kg/m² vs. -0.11 ± 1.33 kg/m², p<0.001) compared to the non-Ertu group. Hypoglycemia was reported in 0.3% of the ertugliflozin group and 0.7% of the other group, with comparable adverse events (p=.23; ≥0.05), indicating a favorable safety profile for ertugliflozin during fasting.

Conclusion

This study demonstrates that ertugliflozin is effective and safe for patients with T2DM during Ramadan fasting.
Evaluation of the impact of the ecological environment damage compensation system on enterprise pollutant emissions
Authors: Li Zhaoyang , Li Yisong
Published: February 2025

The development of an environmental damage compensation framework is a critical innovation in ecological civilization reforms. This study considers the pilot policy for environmental damage compensation reform as a quasi-natural experiment, employing a difference-in-differences approach with emission data from listed companies between 2008 and 2017. The research evaluates the environmental impact of the compensation system’s implementation in pilot areas and its implications for improving environmental legal practices. The results show that the compensation system significantly reduces corporate pollution emissions by 1.93% (p < 0.01), demonstrating its effectiveness as an environmental governance tool. The heterogeneity analysis reveals stronger effects in heavily polluting industries (3.30%, p < 0.01) compared to non-heavily polluting industries (1.25%, p < 0.1), in state-owned enterprises (2.06%, p < 0.01) versus non-state-owned enterprises (1.71%, p < 0.1), and in developed regions (2.50%, p < 0.01) compared to underdeveloped areas (1.00%, not significant). The dual mechanisms of negotiation and litigation in the compensation system impose strict constraints on corporate environmental behavior, effectively addressing the issue of “corporate pollution, public suffering, and government expenses.” To optimize the system, targeted policy recommendations include strengthening negotiation mechanisms, refining judicial responsibilities, and enhancing coordination in underdeveloped regions. These findings highlight the originality and importance of the compensation framework as a model for balancing ecological protection and economic development.
Analysis of the spatial pattern and causes of ecological environmental quality in Myanmar based on the RSEI model and the Geodetector-GCCM method
Authors: Shi Shuangfu , Peng Shuangyun , Lin Zhiqiang , Huang Bangmei , Ma Dongling , Zhu Ziyi , Zhu Yilin , Zhang Rui , Li Ting
Published: February 2025

Facing the challenges brought about by global climate change and biodiversity loss, accurately assessing ecological environmental quality (EEQ), and its driving factors are crucial for formulating effective strategies for ecological protection and restoration. However, there remains limited understanding of the interactions and causal relationships between multiple factors, with existing studies mainly focusing on the impact of individual factors on EEQ and their correlations. This study took Myanmar as the research area, employing a Remote Sensing Ecological Index (RSEI) model and spatial autocorrelation analysis to quantitatively evaluate the spatial distribution characteristics of Myanmar’s EEQ in 2020 and reveal its spatial dependence. Furthermore, by innovatively integrating the Geodetector and Geographical Convergent Cross Mapping (GCCM) methods, this study systematically analyzed the impacts and causal relationships of various factors on the spatiotemporal differentiation of EEQ. The results indicate that: (1) Myanmar’s overall EEQ was relatively good, but there is significant spatial heterogeneity; (2) Local spatial autocorrelation analysis revealed a clear spatial clustering pattern of EEQ in Myanmar; (3) Geodetector analysis identified DEM, slope, Net Primary Productivity (NPP), land use, and human footprint as the dominant factors influencing EEQ, with significant interactions among these factors; (4) GCCM analysis further verified the significant causal effects of DEM, slope, NPP, and human footprint on EEQ, while the causal effects of temperature, precipitation, and land use are relatively weaker. This study established a technical framework for analyzing the spatial differentiation and causes of EEQ, unveiling the mechanisms of ecological evolution driven by natural and human factors. It enriched the understanding of human-environment interactions within coupled systems and delved into the complex mechanisms and causal effects among multiple factors within the ecological system. These insights enhanced our understanding of the intricate relationships between EEQ and its influencing factors, providing valuable references for ecological protection and sustainable development in Myanmar.
Exploration of the relationship between primary dysmenorrhea, pain perception, and menstruation-related quality of life in young women: a cross-sectional observational study
Authors: Del Prado Rebeca , García-Arrabé María , González-de-la-Flor Ángel , De La Plaza San Frutos Marta , Almazán Polo Jaime , Guérineau Fabien , Estrada-Barranco Cecilia
Published: February 2025

Background

This study explores the relationship between primary dysmenorrhea (PD), pain, pain catastrophizing, and menstruation-related quality of life in young women.

Methods

A cross-sectional study was conducted involving 44 young women, both with and without PD. Various variables including pain intensity, pain catastrophizing, and menstruation-related quality of life were assessed using validated questionnaires. Correlation and regression analyses were performed to examine the relationships between the variables.

Results

Significant associations were found between the presence of PD, tendency to catastrophize pain, and decreased menstruation-related quality of life. A high correlation was observed between pain intensity and catastrophizing, indicating mutual influence between these variables. Menstruation-related quality of life was affected in terms of health perception, psychological aspect, and symptoms among women with PD. The linear regression model demonstrated that catastrophizing explained 42.8% of the variance in menstruation-related quality of life.

Conclusions

These findings underscore the importance of addressing dysmenorrhea in young women, as it significantly impacts their quality of life related to menstruation. Understanding the factors contributing to dysmenorrhea and its effects on quality of life can inform more effective, patient-centered treatment strategies.
Advancing risk stratification in kidney transplantation: integrating HLA-derived T-cell epitope and B-cell epitope matching algorithms for enhanced predictive accuracy of HLA compatibility
Authors: Niemann Matthias , Matern Benedict M. , Gupta Gaurav , Tanriover Bekir , Halleck Fabian , Budde Klemens , Spierings Eric
Published: February 2025

Introduction

The immune-mediated rejection of transplanted organs is a complex interplay between T cells and B cells, where the recognition of HLA-derived epitopes plays a crucial role. Several algorithms of molecular compatibility have been suggested, each focusing on a specific aspect of epitope immunogenicity.

Methods

Considering reported death-censored graft survival in the SRTR dataset, we evaluated four models of molecular compatibility: antibody-verified Eplets, Snow, PIRCHE-II and amino acid matching. We have statistically evaluated their co-dependency and synergistic effects between models systematically on 400,935 kidney transplantations using Cox proportional hazards and XGBoost models.

Results

Multivariable models of histocompatibility generally outperformed univariable predictors, with a combined model of HLA-A, -B, -DR matching, Snow and PIRCHE-II yielding highest AUC in XGBoost and lowest BIC in Cox models. Augmentation of a clinical prediction model of pre-transplant parameters by molecular compatibility metrics improved model performance particularly considering long-term outcomes.

Discussion

Our study demonstrates that the use of multiple specialized molecular HLA matching predictors improves prediction performance, thereby improving risk classification and supporting informed decision-making in kidney transplantation.
CH4-C3H8 mixed gas hydrates formation in marine mud and foraminifera-rich sand from the South China Sea: an experimental approach
Authors: Mao Peixiao , Schicks Judith M. , Pan Mengdi , Wu Nengyou
Published: February 2025

CH4-C3H8 mixed gas hydrates are widely distributed in deep-sea weakly-consolidated muddy sediments of the South China Sea, enriched with biological clastics like foraminifera-rich sand. However, the role of complex mineral composition of mud and foraminifera-rich sand on the formation of these natural gas hydrates remains unclear. This study employed five natural sediments from the South China Sea, i.e., foraminifera-rich sand, a mixture of mud and foraminifera-rich sand, and three different mud samples, to reveal their effects on CH4-C3H8 mixed gas hydrate formation. Gas hydrates were formed from water and a constant-feed gas composition containing 96 mol% CH4 and 4 mol% C3H8. The formation process was continuously observed using microscopic observation and in situ Raman spectroscopy. Additional ex situ Raman measurements were also conducted jointly. The results show that only structure II gas hydrates were formed with two crystal morphologies in these sediments, showing no significant differences in gas composition or large-to-small cavity ratio. The concentration of CH4 and C3H8 in the mixed gas hydrates almost did not vary over time in clean foraminifera-rich sand or mud. In a mixture of mud and foraminifera-rich sand, CH4 was preferentially encased into the hydrate cavities at the initial formation stage, while the encasement of C3H8 increased during the ongoing formation process. Not all small 512 cages and large 51264 cages were filled with CH4 during the euhedral hydrate crystals formation. Foraminifera-rich sand, large quartz particles, illite, and kaolinite positively influence the encasement of CH4 into hydrate cavities. These findings provide insights into how marine sediment composition influences gas hydrate formation and their implications for marine ecosystem functioning and structure.
Pulmonary arteriovenous malformation causing lung sequestration and media infarction: a case report
Authors: Griffo Raffaella , Klotz Laura V. , Brendel Lena , Rösch Romina , Niedermaier Benedikt , Schlamp Kai , Kriegsmann Mark , Eichhorn Martin M. , Winter Hauke
Published: February 2025

Pulmonary arteriovenous malformations (PAVMs) are rare vascular malformations of the lungs. Direct communication of pulmonary arteries to pulmonary veins is the defining characteristic allowing venous blood to bypass the pulmonary capillary system and avoiding an efficient oxygenation process. The complexity of the pathology lies not only in the variety of its manifestations, but also in the choice of the most appropriate and effective treatment. We present a case of a complex PAVM associated with a persistent foramen ovale, with stroke as the onset symptom. Despite timely multidisciplinary treatment of the malformation, a potentially fatal pulmonary complication occurred, highlighting the critical importance of early, interdisciplinary management and ongoing follow-up of PAVMs, particularly in preventing life-threatening outcomes.
Spontaneous splenic rupture associated with Q fever and portal hypertension: A case report
Authors: Mustafiz Cecil , Subhaharan Deloshaan , Chorley Daniel , Masood Tariq
Published: February 2025

Spontaneous splenic rupture (SSR) is an exceptionally rare and life-threatening condition, with its pathophysiology remaining poorly understood. This report describes the first documented case of SSR in a patient with Q fever infection and underlying liver cirrhosis with portal hypertension. The patient was a man in his late 30 s who presented with severe abdominal pain, vomiting and hypovolemic shock who required emergency splenectomy due to unstable splenic hemorrhage. Post-operatively, a diagnosis of Q fever was confirmed through serological testing. To date, there has only been six cases describing splenic rupture precipitated by Q fever, and none in the context of concurrent portal hypertension. Conversely, portal hypertension is an independent risk factor for splenic complications including splenomegaly and hypersplenism. This case underlines the critical need to consider rare etiologies, offers valuable insights into the pathogenesis of SSR, and emphasizes the importance of early recognition and multidisciplinary management. Moreover, a proposed algorithm for the diagnosis and management of SSR has been included for clinicians who face similar complex presentations.