bluuebunny/crossref_metadata_2025 huggingface dataset:
Identifying and Addressing Social Determinants of Learning During the COVID-19 Pandemic
Authors: Felter Cara E , Cicone Jonathan , Mathis Lindsey , Smith Deanna L
Published: September 2021

The COVID-19 pandemic has negatively impacted the health of people from communities of color and people of limited socioeconomic means in a disproportionate way due to social determinants of health (SDoH). The Centers for Disease Control defines SDoH as the “conditions in the places where people live, learn, work, and play that affect a wide range of health and quality-of life-risks and outcomes.” A related construct, social determinants of learning (SDoL), includes contextual conditions and variables that impact students’ ability to optimally participate in their education, including academic and clinical development. SDoL directly impact students’ ability to participate in the educational process. During the COVID-19 pandemic, students struggling with SDoH and, by extension SDoL, may be more likely to have sick family members, caregiving responsibilities, food and housing insecurity, and obligations to supplement lost family wages. SDoL are also influenced by individual experiences within and outside of the classroom. Beyond bringing this matter to the attention of our profession, especially clinical and academic educators, we must take action to reach and support students who are at higher academic risk due to the SDoL. The purpose of this paper is to (1) define SDoL, (2) explain how SDoL are impacting doctor of physical therapy and physical therapist assistant students, and (3) discuss actions that physical therapists and physical therapist assistants can take to mitigate the effects of SDoL on current doctor of physical therapy and physical therapist assistant students.

Impact

This Perspective is one of the first explorations of how SDoL affect physical therapy students during the pandemic and provides concrete suggestions on how educators in both academic and clinical settings can help students succeed when they are negatively affected by SDoL.
Awareness of alcohol marketing one year after initial implementation of Ireland’s Public Health (Alcohol) Act and during the COVID-19 pandemic
Authors: Critchlow Nathan , Moodie Crawford
Published: September 2021

Background

The Republic of Ireland is introducing new controls on alcohol marketing, starting in November 2019 with restrictions on some outdoor and cinema advertising, and a ban on public transport advertising. We examined changes in marketing awareness one year after initial implementation and during the COVID-19 pandemic.

Methods

Repeat online cross-sectional surveys with adults in Ireland conducted October 2019 (n = 1,007) and October 2020 (n = 1,020). Participants self-reported past-month awareness of alcohol marketing and completed the Alcohol Use Disorders Identification Test-Concise (AUDIT-C). Current drinkers were categorised as those reporting heavy episodic drinking at least monthly and higher-risk drinkers (≥5 AUDIT-C).

Results

In both waves, most participants recalled some marketing awareness (94.1% vs. 93.8%). For 9/13 activities measured in both waves, there were decreases in the proportion reporting any awareness and frequency of awareness, including for the newly restricted activities. For example, any awareness of public transport advertising decreased between waves (ORAdj = 0.66, 95%CI: 0.53–0.81). In both waves, higher past-month awareness was associated with at least monthly heavy episodic drinking and higher-risk consumption.

Conclusion

We recommend a precautionary interpretation. It is plausible that both Ireland’s initial controls and COVID-19 restrictions contributed to decreases in awareness, but longer-term evaluation is required to determine relative contribution.
Algebras associated with invariant means on the subnormal subgroups of an amenable group
Authors: White Jared T
Published: September 2021

Let G be an amenable group. We define and study an algebra ${\mathcal{A}}_{sn}(G)$, which is related to invariant means on the subnormal subgroups of G. For a just infinite amenable group G, we show that ${\mathcal{A}}_{sn}(G)$ is nilpotent if and only if G is not a branch group, and in the case that it is nilpotent we determine the index of nilpotence. We next study $\textrm{rad}\, \ell^1(G)^{**}$ for an amenable branch group G and show that it always contains nilpotent left ideals of arbitrarily large index, as well as non-nilpotent elements. This provides infinitely many finitely generated counterexamples to a question of Dales and Lau [4], first resolved by the author in [10], which asks whether we always have $(\textrm{rad}\, \ell^1(G)^{**})^{\Box 2} = \{0 \}$. We further study this question by showing that $(\textrm{rad}\, \ell^1(G)^{**})^{\Box 2} = \{0 \}$ imposes certain structural constraints on the group G.
Who Chooses Commitment? Evidence and Welfare Implications
Authors: Carrera Mariana , Royer Heather , Stehr Mark , Sydnor Justin , Taubinsky Dmitry
Published: September 2021

This article investigates whether offers of commitment contracts, in the form of self-imposed choice-set restrictions and penalties with no financial upside, are well-targeted tools for addressing self-control problems. In an experiment on gym attendance (N$=1{,}248$), we examine take-up of commitment contracts and also introduce a separate elicitation task to identify actual and perceived time inconsistency. There is high take-up of commitment contracts for greater gym attendance, resulting in significant increases in exercise. However, this take-up is influenced both by noisy valuation and incorrect beliefs about one’s time inconsistency. Approximately half of the people who take up commitment contracts for higher gym attendance also take up commitment contracts for lower gym attendance. There is little association between commitment contract take-up and reduced-form and structural estimates of actual or perceived time inconsistency. A novel information treatment providing an exogenous shock to awareness of time inconsistency reduces demand for commitment contracts. Structural estimates of a model of quasi-hyperbolic discounting and gym attendance imply that offering our commitment contracts lowers consumer surplus and is less socially efficient than utilizing linear exercise subsidies that achieve the same average change in behaviour.
The Momentum Gap and Return Predictability
Authors: Huang Simon
Published: September 2021

The formation period return difference between past winners and losers, which I call the momentum gap, negatively predicts momentum profits. I document this for the U.S. stock market and find consistent results across 21 major international markets. A one-standard-deviation increase in the momentum gap predicts a 1.25$\%$ decrease in the monthly momentum return after controlling for existing predictors. This predictability extends up to 5 years for static momentum portfolios, consistent with time-varying investor biases. Following the simple real-time strategy of investing in momentum only when the momentum gap is below the 80th percentile delivers a Sharpe ratio of 0.78.
Incidence of chronic immune-mediated inflammatory diseases after diagnosis with Kawasaki disease: a population-based cohort study
Authors: Fung Stephen G , Webster Richard , Kuenzig M Ellen , Knight Braden D , Batthish Michelle , Robinson Cal , Chanchlani Rahul , Benchimol Eric I , Jimenez-Rivera Carolina
Published: September 2021

Objectives

Kawasaki disease (KD) is an immune-mediated vasculitis of childhood with multi-organ inflammation. We determined the risk of subsequent immune-mediated inflammatory disease (IMID), including arthritis, type 1 diabetes, IBD, autoimmune liver disease, primary sclerosing cholangitis and multiple sclerosis.

Methods

We conducted a matched population-based cohort study using health administrative data from Ontario, Canada. Children aged <18 years born between 1991 and 2016 diagnosed with KD (n = 3753) were matched to 5 non-KD controls from the general population (n = 18 749). We determined the incidence of IMIDs after resolution of KD. Three- and 12-month washout periods were used to exclude KD-related symptoms.

Results

There was an elevated risk of arthritis in KD patients compared with non-KD controls, starting 3 months after index date [103.0 vs 12.7 per 100 000 person-years (PYs); incidence rate ratio 8.07 (95% CI 4.95, 13.2); hazard ratio 8.08 (95% CI 4.95, 13.2), resulting in the overall incidence of IMIDs being elevated in KD patients (175.1 vs 68.0 per 100 000 PYs; incidence rate ratio 2.58 (95% CI 1.93, 3.43); hazard ratio 2.58, 95% CI 1.94, 3.43]. However, there was no increased risk for diabetes, IBD, autoimmune liver disease, primary sclerosing cholangitis or multiple sclerosis in KD patients. Similar results were observed using a 12-month washout period.

Conclusion

Children diagnosed with KD were at increased risk of arthritis following the acute KD event, but not other IMIDs. Health-care providers should monitor for arthritis in children following a diagnosis of KD.
Nailfold capillaries and myositis-specific antibodies in anti–melanoma differentiation–associated gene 5 antibody-positive dermatomyositis
Authors: Sugimoto Tomohiro , Mokuda Sho , Kohno Hiroki , Ishitoku Michinori , Araki Kei , Watanabe Hirofumi , Tokunaga Tadahiro , Yoshida Yusuke , Hirata Shintaro , Sugiyama Eiji
Published: September 2021

Objectives

This study aimed to quantify nailfold capillary (NFC) abnormalities in anti–melanoma differentiation–associated gene 5 (MDA5) -positive DM patients and to evaluate the association with clinical parameters, including serum biomarkers. In addition, we aimed to clarify the period leading to remission of NFC abnormalities during immunosuppressive treatment in patients with DM.

Methods

A prospective observational study was conducted including patients (n = 10) who first visited Hiroshima University Hospital and were diagnosed with DM or clinically amyopathic DM with anti-MDA5 antibodies. We compared the NFC abnormalities detected by nailfold-video capillaroscopy (NVC), physical findings, blood tests, respiratory function tests, and vascular-related growth factors measured using a LEGENDplexTM Multi-Analyte Flow Assay Kit.

Results

NFC abnormalities improved in all patients from 2 to 17 weeks after the initiation of immunosuppressive treatment. The NVC scores were inversely correlated with anti-MDA5 antibody titres at baseline. NVC scores and forced vital capacity were positively correlated. Baseline values of M-CSF and stem cell factor were correlated with anti-MDA-5 titres.

Conclusion

Our study suggested that NVC scores and disease activity were inversely correlated before treatment. Vascular-related growth factors, such as M-CSF and stem cell factor, may be associated with the disease mechanism in patients with anti-MDA5 antibody-positive DM.
Bartonella and Coxiella infections presenting as systemic vasculitis: case series and review of literature
Authors: Beydon Maxime , Rodriguez Christophe , Karras Alexandre , Cez Alexandre , Rafat Cédric , Jourde-Chiche Noémie , Fain Olivier , Philipponnet Carole , Puéchal Xavier , Dossier Antoine , Dupin Nicolas , Levy Dan , Aureau Inès , Guillevin Loïc , Terrier Benjamin ,   for the French Vasculitis Study Group (FVSG)
Published: September 2021

Objectives

Coxiella and Bartonella spp. display particular tropism for endothelial or endocardial tissues and an abnormal host response to infections with induced autoimmunity. We aimed, through a case series combined with a comprehensive literature review, to outline characteristics of Coxiella and Bartonella infections presenting as systemic vasculitis.

Methods

We retrospectively included cases of definite Coxiella and Bartonella infections presenting with vasculitis features and performed a comprehensive literature review.

Results

Six cases of Bartonella infections were added to 18 cases from literature review. Causative pathogens were mainly B. henselae. Bartonella infection mimicked ANCA-associated vasculitis in 83% with PR3-ANCA and presented as cryoglobulinaemic vasculitis in 8%. GN was present in 92%, and 88% had endocarditis. Complement fractions were low in 82% and rheumatoid factor positive in 85%. Kidney biopsies showed cell proliferation, mostly crescentic, with pauci-immune GN in 29%. Outcome was favourable, with the use of antibiotics alone in one-third. Five cases of Coxiella infections were added to 16 from literature review. Sixteen had small-vessel vasculitides, mainly cryoglobulinaemia vasculitis in 75%. One patient had polyarteritis nodosa-like vasculitis and four large-vessel vasculitis. Outcome was good except for one death. A highly sensitive next generation sequencing analysis on three Coxiella- and two Bartonella-related vasculitides biopsies did not find any bacterial DNA.

Conclusion

Coxiella and Bartonella are both able to induce vasculitis but display distinct vasculitis features. Bartonella mimics PR3-ANCA-associated vasculitis in the setting of endocarditis, whereas Coxiella may induce vasculitis involving all vessel sizes.
SM03, an anti-human CD22 monoclonal antibody, for active rheumatoid arthritis: a phase II, randomized, double-blind, placebo-controlled study
Authors: Li Jing , Li Mengtao , Wu Di , Zhou Jiaxin , Leung Shui-on , Zhang Fengchun
Published: September 2021

Objective

SM03, a novel chimaeric mAb specific to B cell-restricted antigen CD22, has been developed to treat RA and other B-cell-related diseases. This 24-week phase II randomized, double-blind, multi-dose, placebo-controlled study aimed to evaluate the efficacy and safety of SM03 in moderately-to-severely active RA patients in China.

Methods

One hundred and fifty-six patients on background MTX were randomized in a 1:1:1 ratio to receive a cumulative dose of 3600 mg (high dose, 600 mg × 6 infusions at weeks 0, 2, 4, 12, 14 and 16) or 2400 mg SM03 (low dose, 600 mg × 4 infusions at weeks 0, 2, 12 and 14) or the placebo. The primary outcome was the 24-week ACR 20% improvement criteria (ACR20) response rate. Safety was also assessed.

Results

The 24-week ACR20 response rate was significantly higher with high- (65.3%, P = 0.002) and low-dose SM03 (56.9%, P = 0.024) than with placebo (34.0%), but comparable between the high- and low-dose group. The rate of adverse events was not statistically different among the high-dose group (35.3%), the low-dose group (51.9%) and the placebo group (34.6%). Thirteen (12.6%) patients receiving SM03 reported treatment-emergent infections, including 3.9% patients in the high-dose group. No patients reported severe treatment-emergent infections or malignancies.

Conclusions

In active RA Chinese patients receiving background MTX, SM03 at a cumulative dose of both 2400 mg and 3600 mg is efficacious and well-tolerated throughout the 24 weeks of treatment. Moreover, SM03 has demonstrated a good safety profile.

Trial registration

ClinicalTrials.gov, https://clinicaltrials.gov, NCT04192617.
SIMULATION OF NEUTRON RESPONSE FUNCTIONS OF SILICON SENSOR APPLIED TO REAL-TIME PERSONAL ALBEDO NEUTRON DOSEMETER IN THE ENERGY RANGE BETWEEN 0.01 EV AND 10 KEV
Authors: Abe Yohei , Takada Masashi , Nunomiya Tomoya , Aoyama Kei , Nakamura Takashi , Matsumoto Tetsuro , Masuda Akihiko
Published: September 2021

Neutron response functions of a silicon sensor, which is applied to a new real-time personal albedo neutron dosemeter, have been simulated for low energy neutrons from 0.01 eV to 10 keV using the Monte Carlo technique. The angular neutron response functions were obtained by multiplying simulated neutron energy spectra crossing the neutron sensor and the cross-section of the 6Li(n,t)4He reaction. The neutron response functions have been closed to the dose conversion coefficient of personal doses, Hp(10) recommended by the International Commission on Radiological Protection by selecting neutrons incident from angles of 105° to 180° with respect to an axis perpendicular to an acrylic phantom surface. From these simulation results, the neutron energy response function has been improved by shielding the sensor with cadmium box without a face toward the phantom. The neutron sensor provides a good conformance to the Hp(10) conversion coefficients within 15% for low energy neutrons.
OPTIMIZATION OF LUNG CT PROTOCOL FOR THE DIAGNOSTIC EVALUATION OF COVID-19 LUNG DISEASE
Authors: Hosseini Nasab Seyed Mohammad Bagher , Deevband Mohammad Reza , Rahimi Roghaye , Nasiri Saeed , Ahangaran Mohammad Reza , Morshedi Mina
Published: September 2021

This study intends to evaluate the different lung CT scan protocols used for the diagnostic evaluation of COVID-19-induced lung disease in Iranian imaging centers in terms of radiation dose and image quality. After data collecting, subjective image quality, radiation dose and objective image quality such as noise, SNR and CNR were assessed.

Statistically significant differences in effective dose and image quality were evident among different lung CT protocols. Lowest and highest effective dose was1.31 ± 0.53 mSv related to a protocol with activated AEC (reference mAs = 20) and 6.15 ± 0.57 mSv related to a protocol with Fixed mAs (mAs = 100), respectively.

A protocol with enabled tube current modulation with 70 mAs as a reference mAs, and protocol with 20 mAs and enabled AEC had the best and lowest image quality, respectively. To optimize the scan parameters, AEC must be used, and a range of tube currents (between 20 and 50 mAs) can produce acceptable images in terms of diagnostic quality and radiation dose for the diagnosis of COVID-19-induced lung disease.
Canada’s changing innovation landscape
Authors: Alam Md. Razib , Koo Bonwoo , Cozzarin Brian Paul
Published: September 2021

Our objective is to study Canada’s patenting activity over time in aggregate terms by destination country, by assignee and destination country, and by diversification by country of destination. We collect bibliographic patent data from the Canadian Intellectual Property Office and the United States Patent and Trademark Office. We identify 19,957 matched Canada–US patents, 34,032 Canada-only patents, and 43,656 US-only patents from 1980 to 2014. Telecommunications dominates in terms of International Patent Classification technologies for US-only and Canada–US patents. At the firm level, the greatest number of matched Canada–US patents were granted in the field of telecommunications, at the university level in pharmaceuticals, at the government level in control and instrumentation technology, and at the individual level in civil engineering. We use entropy to quantify technological diversification and find that diversification indices decline over time for Canada and the USA; however, all US indices decline at a faster rate.
Antiseptics leave the Clinic—The Introduction of (Puerperal) Prophylaxis in Austrian Midwifery Education (1870s–1880s)
Authors: Hilber Marina
Published: September 2021

By introducing compulsory antiseptic measures in 1881, the Austrian Empire became a trendsetter in European midwifery legislation. Starting with the focus on puerperal infection in the 1870s, this article investigates the process from the first proposal of antiseptic regimes within a clinical setting to the dissemination of antiseptic knowledge among the midwifery profession. Competition between the leading medical men throughout the Austrian territories played a major role and influenced the way in which antiseptic measures were propagated. The article identifies the antiseptic collectives active at the leading universities of Prague and Vienna. As practical instruction during midwifery education was not regarded as sufficient, the late 1870s and 1880s saw the emergence of several instruction textbooks. Changing birth attendance routines and the innovative materials that entered midwifery practice are explored and discussed, based on these manuals, alongside evidence of midwives’ reactions as published in the Austrian Midwifery Newspaper.
The Plain Meaning Rule: A Quibble about Nomenclature and a Lot More
Authors: Simamba Bilika H
Published: September 2021

In the Cayman Islands, a British Overseas Territory, the proper understanding of the plain meaning rule (or literal rule) of statutory interpretation remains unclear. In its most basic iteration, the rule states that, where a statute is clear and unambiguous, the words must be given their natural and ordinary signification; there is no room for interpretation. That notwithstanding, to this day, even the meaning of the rule, as opposed to its application, still sometimes sparks debate in the Commonwealth. In 2015, a judge of the Grand Court in Cayman held that once a provision in a statute is clear and unambiguous, a court does not need to read the provision in its broader context. In a subsequent case, in 2018, a court of coordinate jurisdiction disagreed. It ruled that, even where a provision appears to be clear and unambiguous, a court must still read the statute in its fuller context in order to decipher the legal meaning in that particular context. This article discusses the plain meaning rule with a view to elucidating its proper understanding while questioning the appropriateness of its continuing nomenclature especially in light of developments in recent decades.
Slow Violence and theGas Peeditin Neoliberal India
Authors: Deb Nikhil
Published: September 2021

This article analyzes the ways in which slow violence and neoliberalism intertwine in the production of social and environmental destruction, evident in the lingering devastation from the 1984 Union Carbide catastrophe in Bhopal, India. Children are born with congenital abnormalities; women are plagued with reproductive health problems; and dangerous chemicals left in the abandoned factory continue to contaminate soil and groundwater. Yet Bhopal is remembered almost exclusively for the spectacle of its immediate aftermath. Drawing on 60 interviews with Bhopal victims and activists, field observations, archives, and official and independent reports, this paper examines how the neoliberal turn in Indian governance plays a role in the creation of slow violence. The paper advances our understanding of socioenvironmental destruction by tying slow violence to a temporal change in countries' governance in the Global South. The paper underscores the significance of considering political economic dynamics in the perpetration of slow violence. It also emphasizes how the neoliberal turn, now anchored in right-wing Hindutva politics in India, further constrains the possibilities for counter-measures that would address slow violence. The paper offers significant implications for analyzing the political economy of socioenvironmental and health disparities in the wake of corporate malfeasance.
Data sharing policies: share well and you shall be rewarded
Authors: Peccoud Jean
Published: September 2021

Sharing research data is an integral part of the scientific publishing process. By sharing data, authors enable their readers to use their results in a way that the textual description of the results does not allow by itself. In order to achieve this objective, data should be shared in a way that makes it as easy as possible for readers to import them in computer software where they can be viewed, manipulated and analyzed. Many authors and reviewers seem to misunderstand the purpose of the data sharing policies developed by journals. Rather than being an administrative burden that authors should comply with to get published, the objective of these policies is to help authors maximize the impact of their work by allowing other members of the scientific community to build upon it. Authors and reviewers need to understand the purpose of data sharing policies to assist editors and publishers in their efforts to ensure that every article published complies with them.
Smith and Philpott v Athol Administration Limited and ors, the Milewood Purpose Trust (2021), CHP2020/93
Authors: Rimmer John
Published: September 2021

A body of case law has now developed in relation to the well-known jurisdiction of common law courts to intervene in voluntary dispositions where they are made on the basis of a serious mistake. But what about the situation where some consideration has been given for the disposition? Does the existence of significant, or any, consideration deny the equitable remedy?
Impaired Spatial Inhibition Processes for Interhemispheric Anti-saccades following Dorsal Posterior Parietal Lesions
Authors: Ouerfelli-Ethier Julie , Salemme Romeo , Fournet Romain , Urquizar Christian , Pisella Laure , Khan Aarlenne Z
Published: September 2021

Anti-saccades are eye movements that require inhibition to stop the automatic saccade to the visual target and to perform instead a saccade in the opposite direction. The inhibitory processes underlying anti-saccades have been primarily associated with frontal cortex areas for their role in executive control. Impaired performance in anti-saccades has also been associated with the parietal cortex, but its role in inhibitory processes remains unclear. Here, we tested the assumption that the dorsal parietal cortex contributes to spatial inhibition processes of contralateral visual target. We measured anti-saccade performance in 2 unilateral optic ataxia patients and 15 age-matched controls. Participants performed 90 degree (across and within visual fields) and 180 degree inversion anti-saccades, as well as pro-saccades. The main result was that our patients took longer to inhibit visually guided saccades when the visual target was presented in the ataxic hemifield and the task required a saccade across hemifields. This was observed through anti-saccades latencies and error rates. These deficits show the crucial role of the dorsal posterior parietal cortex in spatial inhibition of contralateral visual target representations to plan an accurate anti-saccade toward the ipsilesional side.
Differences in branch hydraulic architecture related to the aridity of growing sites and seed sources of coastal Douglas-fir saplings
Authors: Lachenbruch Barbara , St. Clair J Bradley , Harrington Constance A
Published: September 2021

To better understand hydraulic adaptations of coastal Douglas-fir (Pseudotsuga menziesii var. menziesii (Mirb.) Franco) to local climate, we examined genetic (G) and environmental (E) responses of branch hydraulic architecture of 7-year-old saplings from dry and wet climates of origin grown at a relatively dry and a relatively wet common garden site in western Oregon. We sampled 2 years of branch growth from three dry-source and three wet-source families grown at both sites (72 branches, total). Overall, only 4 of the 11 traits had significant genetic (G) effects, whereas 9 traits had significant environmental (E) effects (P < 0.05). Both dry and wet sources had higher leaf-specific conductance (kl) at the dry than the wet site, but the values were achieved by different mechanisms and driven by G × E effects for leaf area/sapwood area (Al/As), shoot length (L), specific conductivity (Ks) and leaf-specific conductivity (Kl). Dry sources achieved higher kl in the dry site through higher Kl (via a lower Al/As and no change in Ks) with no difference in L. Wet sources achieved higher kl at the dry site through no difference in Kl (via no effect on Al/As, despite decreases in Al and As, and lower Ks) with lower L. Vulnerability to embolism (measured as percentage loss of conductivity at 4 MPa) had no G effect but an E effect, with slightly lower values at the dry site. Specific leaf area had G and E effects, with lower values for the dry sources and site. There were no G or E effects on wood density. The different responses of dry and wet sources to site aridity suggest that populations are differentially adapted to the aridity of growing sites. Population variation in response to aridity should be considered when selecting seed sources for establishing forests for future climates.
Is strongyloidiasis currently autochthonous in Croatia? A retrospective study
Authors: Balen Topić Mirjana , Marjanović Ena , Tomasović Domagoj , Sviben Mario
Published: September 2021

Background

Autochthonous human infections with Strongyloides stercoralis have been well documented in many European regions. By exploring patients’ data, we aimed to find elements for its current endemicity in Croatia.

Methods

This retrospective descriptive study analysed epidemiological and clinical data of patients treated for strongyloidiasis from January 2010 to May 2019 at a teaching hospital in Zagreb, Croatia. The diagnosis was made by direct methods using light microscopy and/or serology.

Results

Among 65 patients with strongyloidiasis, 60% were men, and 78.5% were 50–79 y of age. The sensitivity of the examination of three stool samples after concentration, saline provocation and serology was 26.2, 80.7 and 86.2%, respectively. Clinical presentation included asymptomatic patients with eosinophilia (41.5%), chronic symptomatic infection (33.8%), acute infection (18.5%) and hyperinfection (6.2%). Twenty patients (30.8%) were immunosuppressed; among four of whom developed hyperinfection, two died. Initially 71.7% of patients were treated with albendazole and 13.3% with ivermectin, with an equal parasitological cure rate (72.2% and 75%; p=0.09). In 11 patients, acute infection was autochthonous in its origin.

Conclusions

Strongyloidiasis is currently endemic in Croatia and immunosuppressed travellers to this region should be advised to take precautions. Patients undergoing immunosuppression and organ donors from Croatia should be screened.
Learnings from two independent malaria elimination demonstration projects in India
Authors: Rajvanshi Harsh , Mishra Kirti , Bharti Praveen K , Sandhibigraha Debakanta , Nisar Sekh , Jayswar Himanshu , Das Aparup , Pradhan Madan M , Mohapatra Pradipta K , Govil Pallavi Jain , Kshirsagar Nilima , Dash Aditya P , Singh Shrinath , Sahu Ram Shankar , Kaur Harpreet , Dhingra Neeraj , Khan Azadar , Lal Altaf A
Published: September 2021

Problem

India and sub-Saharan Africa contributes about 85% of the global malaria burden, and India is committed to eliminating malaria by 2030.

Approach

Two novel initiatives—the Malaria Elimination Demonstration Project (MEDP) in Madhya Pradesh and Durgama Anchalare Malaria Nirakaran (DAMaN) in Odisha—were initiated independently to demonstrate that indigenous malaria can be eliminated in a short period of time.

Local setting

These initiatives focused on rural, tribal areas where there is a high malaria burden and complex epidemiology.

Relevant changes

The case management and vector control strategies used in these programmes were based on the national guidelines, with context-specific changes and introduction of accountability at management, operational, technical and financial levels. The MEDP achieved a 91% reduction in malaria cases and recorded zero transmission for 6 consecutive and a total of 9 mo. The DAMaN project brought about an 88% reduction in malaria cases.

Lessons learned

Malaria elimination will require robust surveillance and case management, monitoring of vector control interventions, community-centric information education communication and behaviour change communication initiatives and management controls, as well as regular internal and external reviews.
Genomic epidemiology reveals the reduction of the introduction and spread of SARS-CoV-2 after implementing control strategies in Republic of Korea, 2020
Authors: Kwon Jung-Hoon , Kim Jeong-Min , Lee Dong-hun , Park Ae Kyung , Kim Il-Hwan , Kim Da-Won , Kim Ji-Yun , Lim Noori , Cho Kyeong-Yeon , Kim Heui Man , Lee Nam-Joo , Woo SangHee , Lee Chae Young , No Jin Sun , Kim Junyoung , Rhee JeeEun , Han Myung-Guk , Rhie Gi-Eun , Yoo Cheon Kwon , Kim Eun-Jin
Published: September 2021

Genomic epidemiology is a core component in investigating the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this study, the efficacy of control strategies in South Korea was evaluated using genomic epidemiology based on viral genome sequences of 2,065 SARS-CoV-2 cases identified in South Korea from January 2020 to December 2020. Phylogenetic analysis revealed that the majority of viruses introduced from inbound travelers did not further spread throughout South Korea; however, four distinct subgroups (KR.1–4, belonging to B.1.497, B.1, K.1 and B.41) of viruses caused local epidemics. After the introduction of enhanced social distancing, the viral population size and daily case numbers decreased, and KR.2–4 subgroups were extinguished from South Korea. Nevertheless, there was a subsequent increase in KR.1 subgroups after the downgrading of social distancing level. These results indicate that the international traveler quarantine system implemented in South Korea along with social distancing measures efficiently reduced the introduction and spread of SARS-CoV-2, but it was not completely controlled. An improvement of control strategies will be required to better control SARS-CoV-2, its variants, and future pandemic viruses.
The Decay and Fungal Succession of Apples with Bitter Rot Across a Vegetation Diversity Gradient
Authors: Martin Phillip L. , King William L. , Bell Terrence H. , Peter Kari A.
Published: September 2021

Bitter rot is a disease of apple caused by fungi in the genus Colletotrichum. Management begins with removal of infected twigs and fruit from tree canopies to reduce overwintering inoculum. Infected apple fruit are usually tossed to the orchard floor, which is generally managed as herbicide-treated weed-free tree rows, separated by grass drive rows. We monitored decay rates and succession of fungi of apple fruit with bitter rot in tree canopies, and on the soil surface in tree rows, grass drive rows, and nearby diverse plant communities. We hypothesized that decay would occur most rapidly within diverse plant communities, which would provide a more diverse array of potential fungal decomposers. Apple fruit in tree canopies became dry and mummified and had more Colletotrichum gene marker copies the following growing season than did fruit on the soil surface. Of the soil-surface samples, those in grass drive rows and diverse plant communities had higher moisture, faster decay rates, and sharper decreases in Colletotrichum gene marker copies than apple fruit in tree rows. Fungal composition across all decaying apple fruit was dominated by yeasts, with higher genus-level richness, diversity, and evenness in fruit from tree canopies than those on the soil surface. In soil-surface apple fruit, we observed clear successional waves of Pichia, Kregervanrija, and [Candida] yeasts, with similar but distinctly diverging fungal composition. Our results show that orchard floor management can influence fungal succession in apple fruit with bitter rot but suggests that bitter rot management should primarily focus on removing infected apple fruit from tree canopies.
Vitis Species from the Southwestern United States Vary in Their Susceptibility to Powdery Mildew
Authors: Fayyaz Laila , Tenscher Alan , Viet Nguyen Andy , Qazi Huma , Walker M. Andrew
Published: September 2021

The European grapevine (Vitis vinifera L.) has been cultivated in North America for about 500 years. One of the major limitations to its culture is the powdery mildew (PM) fungus, Erysiphe necator Schw. This study reports on the most extensive screening of Vitis species from the southwestern United States and northern Mexico for resistance to PM, testing 147 accessions of 13 Vitis species. In addition, Vitis vinifera cv. Carignane, a highly susceptible wine grape cultivar, was used as a reference to evaluate the effect of the inoculum 14 days postinoculation. Inoculation was done with a vacuum-operated settling tower using a broadly virulent isolate of E. necator, the C-strain. Resistant accessions (nine), moderately susceptible accessions (39), and highly susceptible accessions (99) were detected. The resistant accessions were then inoculated with an additional fungal isolate, e1-101, and they retained their resistance. Vitis species susceptibility was not associated with a North-South gradation, but Western species were more susceptible than Midwestern and Eastern species. All five of the V. monticola accessions were susceptible, as were the accessions of V. treleasei. The species V. acerifolia, V. candicans, V. cinerea, and V. × doaniana had significantly more resistant to moderately susceptible accessions compared with V. arizonica, V. berlandieri, V. californica, V. × champinii, V. girdiana, V. riparia, and V. rupestris, which had relatively more susceptible accessions than the other species. This research identified new sources of PM resistance in Vitis from the southwestern United States that could be incorporated into PM resistance breeding programs throughout the world.
Polymyositis: does it really exist as a distinct clinical subset?
Authors: Leclair Valérie , Notarnicola Antonella , Vencovsky Jiri , Lundberg Ingrid E.
Published: September 2021

Purpose of review

To summarize information on polymyositis; diagnosis, definitions, published data and opinions.

Recent findings

Polymyositis originally referred to inflammatory muscle diseases presenting with muscle weakness and inflammatory cell infiltrates on muscle tissue visible by microscopy. Over time and with improved technology to immunophenotype infiltrating inflammatory cells and characterize muscle fibres, the meaning of polymyositis changed and became more specific. There is ongoing controversy over the term polymyositis, with proponents for a strict definition based on histopathological and immunohistochemical features on muscle biopsies whereas others advocate for a broader clinical and histopathological phenotype. Over the past decades, the discovery of several myositis-specific autoantibodies together with distinct histopathological features have enabled the identification of new subsets previously labelled as polymyositis notably the antisynthetase syndrome and the immune-mediated necrotizing myopathies thus reducing the number of patients classified as polymyositis.

There are still a small number of patients among the idiopathic inflammatory myopathies that can be classified as polymyositis as discussed in this review but the entity is now considered relatively rare.
The dynamic organelle primary cilia: emerging roles in organ fibrosis
Authors: Bhattacharyya Dibyendu , Teves Maria E. , Varga John
Published: September 2021

Purpose of review

Primary cilia, the antenna-like organelles on most mammalian cells, host key components of multiple morphogen signal transduction pathways. Mutations in genes responsible for primary cilia assembly and function generally result in pathological conditions known as ciliopathies, which underlie several diseases, including various forms of fibrosis. Primary cilia modulate cellular responses to extracellular cues, including TGF-β and morphogens, such as Hedgehog. Aberrant morphogen signaling is recognized as essential for the transition of mesenchymal progenitor cells to myofibroblasts, the key step in fibrosis. This article aims to provide a critical overview of recent developments and insights in primary cilia biology relevant to fibrosis.

Recent findings

Several studies have highlighted the association of altered primary cilia with various forms of fibrosis. In a rather complex manner, the presence of primary cilia seems to be required for initiation of myofibroblast transition, whereas its loss promotes myofibroblast transition at a later stage. Recent evidence also suggested that noncanonical functions of ciliary transport proteins may influence, such cellular transitions independently of primary cilia. The possibility of opposing signaling regulations being topologically separated between primary cilia and plasma membrane could also be critical for fibrosis.

Recent progress in the field suggests that primary cilia are critical mediators of the pathogenesis of fibrosis. Understanding the potential role of primary cilia in fibrosis and the underlying mechanisms may pave the way for entirely new approaches for fibrosis prevention and treatment of SSc.
Pulmonary Function Testing Pre–heart Transplant Predicts Posttransplant Survival
Authors: Lundgren Scott W. , Lowes Brian D. , Lyden Elizabeth , Zolty Ronald , Burdorf Adam , Hyden Marshall , Um John , Stoller Douglas A.
Published: September 2021

Introduction.

Although pulmonary function testing (PFT) is typically performed for heart transplant evaluation, the prognostic utility of PFTs after transplantation is unknown. We evaluated whether PFT parameters were correlated with outcomes following heart transplantation.

Methods.

International Society for Heart and Lung Transplantation Thoracic Organ Transplant Registry data were utilized. Survival was assessed using Kaplan-Meier method and compared via log-rank test. Cox proportional hazard modeling was used to evaluate univariate and multivariate predictors of survival.

Results.

Eight hundred two patients pretransplant PFT data were available for evaluation. Forced expiratory volume in 1 s (FEV1) < 50% predicted (P < 0.0001), and forced vital capacity (FVC) < 50% predicted each had significantly higher mortality (P = 0.001) compared with patients with FEV1 or FVC 50%–80% or >80%. FEV1/FVC < 0.7 was not associated with increased mortality. FEV1 and FVC below 50% both predicted longer lengths of stay (P = 0.028 for FEV1 and P = 0.0075 for FVC). After adjusting for male gender, age, body mass index, smoking history, chronic obstructive pulmonary disease, creatinine, albumin, and total bilirubin, FEV1 < 50% (hazard ratio, 4.91; P < 0.0001; 95% confidence interval, 2.69-8.94) and FVC < 50% (hazard ratio, 2.75; P = 0.003; 95% confidence interval, 1.4-5.4) both remained independent predictors of mortality.

Conclusions.

Abnormal pulmonary function (FEV1 or FVC below 50% of predicted) pre–heart transplantation is associated with increased mortality and longer lengths of stay posttransplant.
Prolonged Normothermic Ex Vivo Kidney Perfusion Is Superior to Cold Nonoxygenated and Oxygenated Machine Perfusion for the Preservation of DCD Porcine Kidney Grafts
Authors: Mazilescu Laura I. , Urbanellis Peter , Kaths Moritz J. , Ganesh Sujani , Goto Toru , Noguchi Yuki , John Rohan , Konvalinka Ana , Mucsi Istvan , Ghanekar Anand , Bagli Darius J. , Turgeon Julie , Karakeusian Rimbaud Annie , Hébert Marie-Josée , Dieudé Mélanie , Alleys Isabelle , Dore Etienne , Boilard Eric , Overkleeft Herman S. , Willems Lianne I. , Robinson Lisa A. , Selzner Markus
Published: September 2021

Background.

The increased usage of marginal grafts has triggered interest in perfused kidney preservation to minimize graft injury. We used a donation after circulatory death (DCD) porcine kidney autotransplantation model to compare 3 of the most frequently used ex vivo kidney perfusion techniques: nonoxygenated hypothermic machine perfusion (non-oxHMP), oxygenated hypothermic machine perfusion (oxHMP), and normothermic ex vivo kidney perfusion (NEVKP).

Methods.

Following 30 min of warm ischemia, grafts were retrieved and preserved with either 16 h of non-oxHMP, oxHMP, or NEVKP (n = 5 per group). After contralateral nephrectomy, grafts were autotransplanted and animals were followed for 8 d. Kidney function and injury markers were compared between groups.

Results.

NEVKP demonstrated a significant reduction in preservation injury compared with either cold preservation method. Grafts preserved by NEVKP showed superior function with lower peak serum creatinine (NEVKP versus non-oxHMP versus oxHMP: 3.66 ± 1.33 mg/dL, 8.82 ± 3.17 mg/dL, and 9.02 ± 5.5 mg/dL) and more rapid recovery. The NEVKP group demonstrated significantly increased creatinine clearance on postoperative day 3 compared with the cold perfused groups. Tubular injury scores on postoperative day 8 were similar in all groups.

Conclusions.

Addition of oxygen during HMP did not reduce preservation injury of DCD kidney grafts. Grafts preserved with prolonged NEVKP demonstrated superior initial graft function compared with grafts preserved with non-oxHMP or oxHMP in a model of pig DCD kidney transplantation.
The variability in neurological deficits in Duchenne muscular dystrophy patients may be explained by differences in dystrophin glycoprotein complexes in the brain and muscle
Authors: Verghese Elizabeth
Published: September 2021

Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic neuromuscular disorder. The variability in neurologic deficits in DMD patients may be explained by the fact that (1) dystrophin containing complexes in the brain are more stable than dystrophin containing complexes in the muscle (2) neurons are not affected by the same stresses as muscle and (3) neurons have a greater capacity to buffer increases in intracellular calcium levels. In the muscle, the loss of dystrophin and subsequent loss of dystrophin-associated proteins (DAPs) affects the stability of the dystrophin-glycoprotein complex and calcium ion channels. It causes the sarcolemma of the muscle to tear and calcium ion leak. The subsequent calcium influx leads to calcium dependant proteolysis. In the brain, the structure of the dystrophin-containing complexes is completely different from the muscle. There are several dystrophin isoforms that combine with a completely different set of proteins compared to the muscle to form several different dystrophin-containing complexes. In addition, the loss of dystrophin does not affect the expression of DAPs. The heterogeneity of dystrophin-containing complexes and the continued expression of DAPs will result in more stable dystrophin-containing complexes in the DMD brain. Muscles are under more stress than neurons as they undergo contractions. This combined with txhe fact that the neurons have a better ability to buffer increases in calcium would suggest that neurons are less likely to be damaged despite the loss of dystrophin.
Coupled effect of particle size of the source materials and calcination temperature on the direct synthesis of hydroxyapatite
Authors: Hossain Md. Sahadat , Mahmud Monika , Sultana Sazia , Bin Mobarak Mashrafi , Islam M. Saiful , Ahmed Samina
Published: September 2021

We report the effect of controlled particle size (obtained by using 80, 100, 120, 140 and 200 mesh) of the source materials on the synthesis of a well-known biomaterial, hydroxyapatite (Hap). In addition to this, we have also mapped the consequence of applied temperature (700°C, 800°C and 900°C) on the crystallographic properties and phase composition of the obtained Hap. Nevertheless, although with Hap, in each case, β-tricalcium phosphate (β-TCP) was registered as the secondary phase the ANOVA test revealed that the results of the crystallographic parameters are significantly different for the applied sintering temperature 700°C and 800°C (
p
< 0.05), while the data obtained for calcination temperature 800°C are not significantly different from that acquired at 900°C (
p
> 0.05). Fourier transform infrared spectrophotometer data ensured that, irrespective of mesh size and calcination temperature, the synthesized Hap samples were of carbonated apatite with B-type substitution. Interestingly, for all cases, the % of carbonate content was below the maximum limit (8%) of the

CO

3

2
−

ion present in bone tissue hydroxyapatite.