bluuebunny/crossref_metadata_2025 huggingface dataset:
An All-in-One Tool for 2D Atherosclerotic Disease Assessment and 3D Coronary Artery Reconstruction
Authors: Kyriakidis Savvas , Rigas George , Kigka Vassiliki , Zaridis Dimitris , Karanasiou Georgia , Tsompou Panagiota , Karanasiou Gianna , Lakkas Lampros , Nikopoulos Sotirios , Naka Katerina K. , Michalis Lampros K. , Fotiadis Dimitrios I. , Sakellarios Antonis I.
Published: March 2023

Diagnosis of coronary artery disease is mainly based on invasive imaging modalities such as X-ray angiography, intravascular ultrasound (IVUS) and optical coherence tomography (OCT). Computed tomography coronary angiography (CTCA) is also used as a non-invasive imaging alternative. In this work, we present a novel and unique tool for 3D coronary artery reconstruction and plaque characterization using the abovementioned imaging modalities or their combination. In particular, image processing and deep learning algorithms were employed and validated for the lumen and adventitia borders and plaque characterization at the IVUS and OCT frames. Strut detection is also achieved from the OCT images. Quantitative analysis of the X-ray angiography enables the 3D reconstruction of the lumen geometry and arterial centerline extraction. The fusion of the generated centerline with the results of the OCT or IVUS analysis enables hybrid coronary artery 3D reconstruction, including the plaques and the stent geometry. CTCA image processing using a 3D level set approach allows the reconstruction of the coronary arterial tree, the calcified and non-calcified plaques as well as the detection of the stent location. The modules of the tool were evaluated for efficiency with over 90% agreement of the 3D models with the manual annotations, while a usability assessment using external evaluators demonstrated high usability resulting in a mean System Usability Scale (SUS) score equal to 0.89, classifying the tool as “excellent”.
Optical Coherence Tomography Angiography in Macular Holes Autologous Retinal Transplant
Authors: Morales-Canton Virgilio , Meizner-Grezemkovsky Daniela , Baquero-Ospina Pablo , Crim Nicolás , Wu Lihteh
Published: March 2023

In this paper, we compare the post-operative macular microvascular parameters (vascular density and foveal avascular zone) in eyes with refractory macular hole (MH) that underwent pars plana vitrectomy and autologous retinal transplant (ART) with the fellow unoperated eye. We conducted a retrospective case control study of six consecutive patients who underwent pars plana vitrectomy and ART with at least six months of post-operative follow-up. Pre-operatively, all eyes underwent SD-OCT (Spectral Domain Optical Coherence Tomography) examination. Post-operative OCT-A analyses included vascular density (VD) and the foveal avascular zone (FAZ) area. Six patients with a mean age of 63.7 ± 14.3 years were included. The mean follow-up was 24 months (range 6–30 months). The pre-operative BCVA (best-corrected visual acuity) was 0.99 ± 0.46 logMAR and 1.02 ± 0.23 logMAR at the last post-operative visit (p = 1.00). The mean MH diameter was 966 ± 620 µm. VD in the MH group was 28.1 ± 7.3% compared to 20.2 ± 2.9% in the fellow eyes group (p < 0.05). The mean post-operative FAZ area in the MH group was 109.8 ± 114.6 mm2 compared to 41.5 ± 10.4 mm2 in the control group (p < 0.05). In all six eyes, MH closure was obtained. The post-operative visual acuity did not improve after ART. Eyes with a closed MH showed a bigger FAZ with a higher VD compared to the fellow healthy eye.
Objective Classification of Glistening in Implanted Intraocular Lenses Using Optical Coherence Tomography: Proposal for a New Classification and Grading System
Authors: Fernández-Vigo José Ignacio , Burgos-Blasco Bárbara , De-Pablo-Gómez-de-Liaño Lucía , Sánchez-Guillén Inés , Albitre-Barca Virginia , Fernández-Aragón Susana , Fernández-Vigo José Ángel , Macarro-Merino Ana
Published: March 2023

Purpose: To propose a classification of the glistening in intraocular lenses (IOL) using swept-source optical coherence tomography (SS-OCT) by means of a simple, objective and reproducible method that allows the quantification of the presence and severity of glistening. Methods: A cross-sectional study on a sample of 150 eyes of 150 patients who underwent cataract surgery in at least 600 days before the exam and attended a routine examination. Each subject was examined by SS-OCT after pupil dilation, identifying the presence of glistening or hyperreflective foci (HRF) in the central area of the IOL. The degree of glistening was classified into four categories: 0: ≤5 HRF; 1: 6 to 15 HRF; 2: 16 to 30 HRF; and 3: >30 HRF. The intra and interobserver reproducibility (intraclass correlation coefficient, ICC) in the quantification and classification of the glistening were calculated. The correlation between the horizontal and vertical scan of the IOL was also assessed. Results: Glistening was present in the IOL in 42.7% of the patients. The mean number of HRF or glistening microvacuoles was 10.4 ± 26.2 (range 0 to 239). In total, 63.3% of the IOLs had a grade 0, 20% grade a 1, 6.7% grade a 2 and 10% a grade 3. The intraobserver and interobserver reproducibility were very high, both for the absolute quantification of the glistening (ICC ≥ 0.994) and for the severity scale (ICC ≥ 0.967). There was an excellent correlation in the quantification of the IOL glistening between the horizontal and vertical scans (R ≥ 0.834; p < 0.001). Conclusions: The use of SS-OCT makes it possible to identify, quantify and classify IOL glistening in a simple, objective and reproducible way. This technique could provide relevant information for the study of the glistening on IOLs.
Are There Any Differences in Road Traffic Injury Outcomes between Older and Younger Adults? Setting the Grounds for Posttraumatic Senior Personal Injury Assessment Guidelines
Authors: Cunha-Diniz Flávia , Taveira-Gomes Tiago , Santos Agostinho , Teixeira José Manuel , Magalhães Teresa
Published: March 2023

Injury outcomes seem to be more severe in older than younger persons. This may make personal injury assessment (PIA) particularly difficult, mainly because of seniors’ previous health frailties. To set the grounds for seniors’ PIA guidelines, we compared an older with a younger adult population of trauma victims and, secondarily, identified differences between the groups regarding three-dimensional and medico-legal damage parameters assessment. Using a retrospective study of victims of road traffic accidents, we compared the groups (n = 239 each), assuring similar acute injury severity (ISS standardised difference = 0.01): G1 (older adults); G2 (younger adults). Logistic regression was used to estimate the odds ratio. G1 revealed higher negative consequences when considering the three-dimensional damage assessment, with more frequent and severe outcomes, being a cause of further difficulties in daily living activities, with a loss of independence and autonomy. Nevertheless, regarding the medico-legal damage parameters, permanent functional disability did not show significant differences. This study generates evidence that reveals the need to rethink the traditional methodology of PIA in older persons, giving more relevance to the real-life contexts of each person. It is essential to: obtain complete information about previous physiologic and health states, begin the medico-legal assessment as early as possible, make regular follow-ups, and perform a multidisciplinary evaluation.
Only EBUS-Guided Mediastinal Lymph Node Cryobiopsy Enabled Immunotherapy in a Patient with Non-Small Cell Lung Cancer
Authors: Hetzel Jürgen , Mauti Laetitia A. , Winkler Jonas , Cardoso Almeida Sabine , Jermann Philip , Pless Miklos , Bubendorf Lukas , Bode Peter Karl , Häntschel Maik
Published: March 2023

Personalized treatment of metastatic non-squamous non-small cell lung cancer (NSCLC) requires detailed molecular characterization of the tumour including detection of predictive driver mutations and programmed death ligand 1 (PD-L1) expression. Complete detection is influenced by the amount of tumour cells sampled as well as their quality. Different sampling techniques may be necessary to provide sufficient tumour material for comprehensive molecular characterization. Missing the detection of targetable molecular genetic aberrations would have a serious impact on the quality of life and prognosis of a patient. This case report highlights the importance of biopsy technique in a patient with NSCLC. Several procedures—pleural puncture, transthoracic lung biopsy and endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA)—could not provide sufficient tumour material for precise tumour characterization. Only the addition of EBUS-guided transbronchial lymph node cryobiopsy (EBUS-TBLNC) enabled complete immunohistochemical and genetic tumour characterization, demonstrating PD-L1 expression in 100% of the tumour cells in the absence of actionable genetic alterations. Based on these results, immunotherapy was initiated.
Audiovisual Training in Virtual Reality Improves Auditory Spatial Adaptation in Unilateral Hearing Loss Patients
Authors: Alzaher Mariam , Valzolgher Chiara , Verdelet Grégoire , Pavani Francesco , Farnè Alessandro , Barone Pascal , Marx Mathieu
Published: March 2023

Unilateral hearing loss (UHL) leads to an alteration of binaural cues resulting in a significant increment of spatial errors in the horizontal plane. In this study, nineteen patients with UHL were recruited and randomized in a cross-over design into two groups; a first group (n = 9) that received spatial audiovisual training in the first session and a non-spatial audiovisual training in the second session (2 to 4 weeks after the first session). A second group (n = 10) received the same training in the opposite order (non-spatial and then spatial). A sound localization test using head-pointing (LOCATEST) was completed prior to and following each training session. The results showed a significant decrease in head-pointing localization errors after spatial training for group 1 (24.85° ± 15.8° vs. 16.17° ± 11.28°; p < 0.001). The number of head movements during the spatial training for the 19 participants did not change (p = 0.79); nonetheless, the hand-pointing errors and reaction times significantly decreased at the end of the spatial training (p < 0.001). This study suggests that audiovisual spatial training can improve and induce spatial adaptation to a monaural deficit through the optimization of effective head movements. Virtual reality systems are relevant tools that can be used in clinics to develop training programs for patients with hearing impairments.
Unusual Evolution of Hypertrophic Cardiomyopathy in Non-Compaction Myocardium in a Pompe Disease Patient
Authors: Gragnaniello Vincenza , Rizzardi Caterina , Commone Anna , Gueraldi Daniela , Maines Evelina , Salviati Leonardo , Di Salvo Giovanni , Burlina Alberto B.
Published: March 2023

Classic infantile Pompe disease is characterized by a severe phenotype with cardiomyopathy and hypotonia. Cardiomyopathy is generally hypertrophic and rapidly regresses after enzyme replacement therapy. In this report, for the first time, we describe a patient with infantile Pompe disease and hypertrophic cardiomyopathy that evolved into non-compaction myocardium after treatment. The male newborn had suffered since birth with hypertrophic cardiomyopathy and heart failure. He was treated with standard enzyme replacement therapy (ERT) (alglucosidase alfa) and several immunomodulation cycles due to the development of anti-ERT antibodies, without resolution of the hypertrophic cardiomyopathy. At the age of 2.5 years, he was treated with a new combination of ERT therapy (cipaglucosidase alfa) and a chaperone (miglustat) for compassionate use. After 1 year, the cardiac hypertrophy was resolved, but it evolved into non-compaction myocardium. Non-compaction cardiomyopathy is often considered to be a congenital, primitive cardiomyopathy, due to an arrest of compaction of the myocardium wall during the embryonal development. Several genetic causes have been identified. We first describe cardiac remodeling from hypertrophic cardiomyopathy to a non-compaction form in a patient with infantile Pompe disease treated with a new ERT. This has important implications both for the monitoring of Pompe disease patients and for the understanding of the pathophysiological basis of non-compaction myocardium.
Retinal Pigment Epithelial Characteristics in Acute and Resolved Vogt-Koyanagi-Harada Disease
Authors: Jacob Ninan , Tyagi Mudit , Chhablani Jay , Narayanan Raja , Kelgaonkar Anup , Jain Mukesh , Singh Sumit , Sahoo Niroj
Published: March 2023

Vogt-Koyanagi-Harada (VKH) disease is an auto-immune inflammatory disease of choroidal origin. During the acute stage, optical coherence tomography (OCT), however, may not be able to assess the entire choroid. The aims of the paper were to evaluate the role of retinal pigment epithelium (RPE) as a biomarker of inflammation in acute VKH. This was a retrospective observational study done in 55 eyes of 29 patients with acute VKH. RPE thickness, total choroidal thickness, and RPE reflectivity before and after resolution were analyzed using image J software. Correlations between several baseline and post-resolution parameters were performed, and factors affecting change in visual acuity were analyzed. A significant decrease in RPE thickness and a significant increase in RPE reflectivity were seen following resolution of the disease. Furthermore, there was a significant correlation between RPE and choroidal thickness during the acute stage of the disease. Baseline visual acuity and the presence of bacillary detachment at baseline were the only factors responsible for changes in visual acuity. We propose the utility of RPE layer as a surrogate biomarker of choroidal activity and inflammation in terms of RPE reflectivity and RPE thickness during the acute stage of VKH, especially when there is poor imaging of the choroid.
Hypereosinophilic Syndrome Following the BNT162b2 (BioNTech/Pfizer) Vaccine Successfully Treated with Mepolizumab: A Case Report and Review of the Literature
Authors: Hoxha Ariela , Tomaselli Tania , Minicucci Giacomo Maria , Dall’Acqua Jacopo , Zardo Davide , Simioni Paolo , Naldi Luigi
Published: March 2023

Although an increasing number of real-life data confirm large-scale clinical trial findings on the efficacy and safety of SARS-CoV-2 vaccines, rare but severe adverse reactions have begun to emerge. Here, we report a full-blown hypereosinophilic syndrome (HES) following a BNT162b2 (BioNTech/Pfizer) vaccine. A 48-year-old man developed, 5 days after the first shot of the SARS-CoV-2 vaccine, erythematous and painful nodular lesions in the lower and upper limbs accompanied by widespread itching, acrocyanosis with gangrenous lesions at the tips of the first and fourth fingers of the right hand, as well as paresthesia in the right hand and foot. Investigations revealed isolated eosinophilia, occlusion of the right ulnar artery, and electromyography alteration compatible with multifocal sensory neuropathy, as well as minimal accentuation of the interstitial texture with some ground glass appearance. Despite treatment with prednisone in combination with warfarin, he developed thrombosis of the left ulnar artery. Therefore, therapy with an IL-5 inhibitor and acetylsalicylic was successfully added. Given the time interval between the onset of clinical manifestations and the vaccine shot, we believe that the mRNA vaccine triggered the eosinophilic response. This case evidences a possible link between HES and the SARS-CoV-2 vaccination. Mepolizumab, an IL-5 inhibitor, might be considered in steroid refractory cases.
Lung Function Impairment, Associating Hyperinflation with Impaired Diffusion Capacity and Transfer Coefficient, Is a Risk Factor for Hip Osteoporosis in Patients with Chronic Obstructive Pulmonary Disease
Authors: Malaise Olivier , André Cécile , Van Durme Caroline , Seidel Laurence , Schleich Florence , Louis Renaud , Malaise Michel , Ribbens Clio
Published: March 2023

Chronic obstructive pulmonary disease (COPD) is a risk factor for osteoporosis. Our objective is to determine if functional indices associated with emphysema on pulmonary function tests (DLCO—diffusion capacity of the lung for CO-; DLCO/AV—DLCO corrected for alveolar volume- and TLC—total lung capacity), considered alone or together, can identify COPD patients with osteoporosis. Methods: 90 COPD patients underwent dual-energy X-ray absorptiometry (DEXA) and pulmonary function tests. Results: 26% of the COPD patients were osteoporotic. In univariate analysis, each functional parameter associated with emphysema, analyzed separately, was not associated with osteoporosis. In contrast, patients with hyperinflation associated with impaired diffusion capacity and transfer coefficient, defined by the association of the three functional indices (DLCO < 70%, DLCO/AV < 80% and CPT > 115%), had significantly more osteoporosis at the total hip (OR: 5.9, CI: 1.5–23.8, p = 0.013). In multivariate analysis, this phenotype was confirmed as an independent factor associated with hip osteoporosis. In contrast, COPD airway obstruction severity, based on FEV1 (%), was not associated with osteoporosis. A lower BMI, female gender and age were also identified as osteoporosis risk factors. Conclusions: COPD patients with hyperinflation associated with impaired diffusion capacity and transfer coefficient are at higher risk for osteoporosis. Pulmonary function tests associated with emphysema detection can help to identify COPD patients with osteoporosis, in addition to the classical risk factors.
The Relationship of CCL5 and CCR1 Variants with Response Rate and Survival Taking into Account Thalidomide/Bortezomib Treatment in Patients with Multiple Myeloma
Authors: Popek-Marciniec Sylwia , Styk Wojciech , Wojcierowska-Litwin Magdalena , Szudy-Szczyrek Aneta , Dudek Paul , Swiderska-Kolacz Grazyna , Czerwik-Marcinkowska Joanna , Zmorzynski Szymon
Published: March 2023

(1) Background: Chemokines and chemokine receptors play an important role in tumor development. The aim of this study was to check the significance of CCL5 and CCR1 variants with response rate, survival, and the level of regulated on activation, normal T cells expressed and secreted (RANTES/CCL5) in multiple myeloma (MM) patients; (2) Methods: Genomic DNA from 101 newly diagnosed MM patients and 100 healthy blood donors were analyzed by Real-time PCR method (for CCL5 and CCR1 genotyping). In a subgroup of 70 MM patients, serum samples were collected to determine the level of RANTES; (3) Results: multivariate Cox regression showed increased risk of disease relapse or progression (HR = 4.77; p = 0.01) in MM patients with CG + CC genotypes of CCL5 rs2280788. In contrast, CT + TT genotypes of CCL5 rs2107538 were associated withdecreased risk of death (HR = 0.18; p = 0.028) and disease relapse or progression (HR = 0.26; p = 0.01). In MM patients with major genotypes of rs2280789, rs2280788, and rs2107538, higher survival rates were observed in response to treatment with thalidomide and bortezomib. Statistically significant lower RANTES levels were seen in minor genotypes and heterozygotes of CCL5 and CCR1 variants; (4) Conclusions: Major genotypes of CCL5 variants may be independent positive prognostic factors in MM.
Delirium Risk Score in Elderly Patients with Cervical Spinal Cord Injury and/or Cervical Fracture
Authors: Tamai Koji , Terai Hidetomi , Nakamura Hiroaki , Yokogawa Noriaki , Sasagawa Takeshi , Nakashima Hiroaki , Segi Naoki , Ito Sadayuki , Funayama Toru , Eto Fumihiko , Yamaji Akihiro , Watanabe Kota , Yamane Junichi , Takeda Kazuki , Furuya Takeo , Yunde Atsushi , Nakajima Hideaki , Yamada Tomohiro , Hasegawa Tomohiko , Terashima Yoshinori , Hirota Ryosuke , Suzuki Hidenori , Imajo Yasuaki , Ikegami Shota , Uehara Masashi , Tonomura Hitoshi , Sakata Munehiro , Hashimoto Ko , Onoda Yoshito , Kawaguchi Kenichi , Haruta Yohei , Suzuki Nobuyuki , Kato Kenji , Uei Hiroshi , Sawada Hirokatsu , Nakanishi Kazuo , Misaki Kosuke , Kuroda Akiyoshi , Inoue Gen , Kakutani Kenichiro , Kakiuchi Yuji , Kiyasu Katsuhito , Tominaga Hiroyuki , Tokumoto Hiroto , Iizuka Yoichi , Takasawa Eiji , Akeda Koji , Takegami Norihiko , Funao Haruki , Oshima Yasushi , Kaito Takashi , Sakai Daisuke , Yoshii Toshitaka , Ohba Tetsuro , Otsuki Bungo , Seki Shoji , Miyazaki Masashi , Ishihara Masayuki , Okada Seiji , Imagama Shiro , Kato Satoshi
Published: March 2023

The number of elderly patients with cervical trauma is increasing. Such patients are considered to be at high risk for delirium, which is an acute neuropsychological disorder that reduces the patient’s capacity to interact with their environment due to impairments in cognition. This study aimed to establish a risk score that predicts delirium in elderly patients with cervical SCI and/or cervical fracture regardless of treatment type. This retrospective cohort study included 1512 patients aged ≥65 years with cervical SCI and/or cervical fracture. The risk factors for delirium according to treatment type (surgical or conservative) were calculated using multivariate logistic regression. A delirium risk score was established as the simple arithmetic sum of points assigned to variables that were significant in the multivariate analyses. Based on the statistical results, the delirium risk score was defined using six factors: old age (≥80 years), hypoalbuminemia, cervical fracture, major organ injury, dependence on pre-injury mobility, and comorbid diabetes. The score’s area under the curve for the prediction of delirium was 0.66 (p < 0.001). Although the current scoring system must be validated with an independent dataset, the system remains beneficial because it can be used after screening examinations upon hospitalization and before deciding the treatment strategy.
The Impact of Emergency Department Arrival Time on Door-to-Balloon Time in Patients with ST-Segment Elevation Myocardial Infarction Receiving Primary Percutaneous Coronary Intervention
Authors: Hsiao Yu-Ting , Hung Jui-Fu , Zhang Shi-Quan , Yeh Ya-Ni , Tsai Ming-Jen
Published: March 2023

Door-to-balloon (DTB) time significantly affects the prognosis of patients with ST-segment elevation myocardial infarction (STEMI). The effects of temporal differences in emergency department (ED) arrival time on DTB time and on different segments of DTB time remain inconclusive. Therefore, we performed a retrospective study in a tertiary hospital between January 2013 and December 2021 and investigated the relationship between a patient’s arrival time and both their DTB time and different segments of their DTB time. Of 732 STEMI patients, 327 arrived during the daytime (08:01–16:00), 268 during the evening (16:01–24:00), and 137 at night (00:01–08:00). Significantly higher odds of delay in DTB time were observed during the nighttime (adjusted odds ratio (aOR): 2.87; 95% confidence interval (CI): 1.50–5.51, p = 0.002) than during the daytime. This delay was mainly attributed to a delay in cardiac catheterization laboratory (cath lab) activation-to-arrival time (aOR: 6.25; 95% CI: 3.75–10.40, p < 0.001), particularly during the 00:00–04:00 time range. Age, sex, triage level, and whether patients arrived during the COVID-19 pandemic also had independent effects on different segments of DTB time. Further studies are required to investigate the root causes of delay in DTB time and to develop specific strategies for improvement.
Experience-Related Factors in the Success of Beginner Endoscopic Ultrasound-Guided Biliary Drainage: A Multicenter Study
Authors: Sagami Ryota , Mizukami Kazuhiro , Okamoto Kazuhisa , Noguchi Chishio , Sato Takao , Nishikiori Hidefumi , Kawahara Yoshinari , Wada Masahiro , Otsuka Yuichiro , Fukuchi Satoshi , Takihara Hiroshi , Kuraoka Naosuke , Suzuki Keita , Murakami Kazunari
Published: March 2023

Endoscopic ultrasound-guided biliary drainage (EUS-BD) has become comparable to endoscopic retrograde cholangiopancreatography and is now considered a first-line intervention for certain biliary obstructions. Although analysis of experience-related factors may help achieve better outcomes and contribute to its wider adoption, no concrete evidence exists regarding the required operator or institutional experience levels. This study aimed to analyze experience-related factors at beginner multicenters. Patients who underwent EUS-BD using self-expandable metal stents and/or dedicated plastic stents during the study period (up to the first 25 cases since introducing the technique) were retrospectively enrolled from seven beginner institutions and operators. Overall, 90 successful (technical success without early adverse events) and 22 failed (technical failure and/or early adverse events) cases were compared. EUS-BD-related procedures conducted at the time of applicable EUS-BD by each institution/operator were evaluated. The number of institution-conducted EUS-BD procedures (≥7) and operator-conducted EUS screenings (≥436), EUS-guided fine-needle aspirations (FNA) (≥93), and EUS-guided drainages (≥13) significantly influenced improved EUS-BD outcomes (p = 0.022, odds ratio [OR], 3.0; p = 0.022, OR, 3.0; p = 0.022, OR, 3.0; and p = 0.028, OR, 2.9, respectively). Our threshold values, which significantly divided successful and failed cases, were assessed using receiver operating characteristic curve analysis and may provide useful approximate indications for successful EUS-BD.
The Use of Premixed Calcium Silicate Bioceramic Sealer with Warm Carrier-Based Technique: A 2-Year Study for Patients Treated in a Master Program
Authors: Zamparini Fausto , Spinelli Andrea , Cardinali Filippo , Ausiello Pietro , Gandolfi Maria Giovanna , Prati Carlo
Published: March 2023

Background: Recently several calcium silicate flowable sealers have been introduced as endodontic materials for the root canal. This clinical study tested the use of a new premixed calcium silicate bioceramic sealer in association with the Thermafil warm carrier-based technique (TF). Epoxy-resin-based sealer with the warm carrier-based technique was the control group. Methodology: Healthy consecutive patients (n = 85) requiring 94 root canal treatments were enrolled in this study and assigned to one filling group (Ceraseal-TF n = 47, AH Plus-TF n = 47) in accordance with operator training and best clinical practice. Periapical X-rays were taken preoperatively, after root canal filling and after 6, 12 and 24 months. Two evaluators blindly assessed the periapical index (PAI) and sealer extrusion in the groups (k = 0.90). Healing rate and survival rate were also evaluated. Chi-square tests was used to analyze significant differences between the groups. Multilevel analysis was performed to evaluate the factors associated with healing status. Results: A total of 89 root canal treatments in 82 patients were analyzed at the end-line (24 months). The total drop-out was 3.6% (3 patients; 5 teeth). A total of 91.1% of healed teeth (PAI 1-2) was observed in Ceraseal-TF, with 88.6% in AH Plus-TF. No significant difference was observed on healing outcome and survival among the two filling groups (p > 0.05). Apical extrusion of the sealers occurred in 17 cases (19.0%). Of these, 6 occurred in Ceraseal-TF (13.3%) and 11 in AH Plus-TF (25.0%). Three Ceraseal extrusions were radiographically undetectable after 24 months. All the AH Plus extrusions did not change during the evaluation time. Conclusions: The combined use of the carrier-based technique and premixed CaSi-based bioceramic sealer showed clinical results comparable with carrier-based technique and epoxy-resin-based sealer. The radiographical disappearance of apically extruded Ceraseal is a possible event in the first 24 months.
Weldability of 316L Parts Produced by Metal Additive Manufacturing
Authors: Selmi Hamdi , Brousseau Jean , Caron-Guillemette Gabriel , Goulet Stéphane , Desjardins Jacques , Belzile Claude
Published: March 2023

The processes of metal additive manufacturing (AM) are no longer confined to rapid prototyping applications and are seeing increasing use in many fields for the production of tools and finished products. The ability to design parts with practically zero waste, high precision, complex geometry, and on-demand fabrication are among the advantages of this manufacturing approach. One of the drawbacks of this technique is the productivity rate, as the parts are made layer by layer, which also increases the production cost. Moreover, even the working space is limited, especially for the powder bed fusion technique. In view of these disadvantages and in order to guarantee the profitability of this process, it should be oriented to the production of complex components that have a limited volume with a design adapted to additive manufacturing. One solution with which to circumvent these drawbacks is to combine the 3D printing process with conventional manufacturing processes. When designing products, one may choose to use additive manufacturing to create locally complex parts and assemble them with parts produced by conventional processes. On the other hand, and due to the limited AM printing chamber space, it may be necessary to print large parts in multiple smaller parts and then assemble them. In order to investigate the weldability of stainless steel 316L parts produced by laser powder bed fusion (L-PBF), the mechanical behavior of different welding assemblies is tested. Five configurations are studied: non-welded AM specimens, two AM parts welded together, one AM part and one laser cut part welded together, two laser-cut parts welded together, and non-welded laser cut specimens. Welding is performed using the Pulsed Gas Metal Arc Welding process (GMAW-P). Specimen strength is assessed through static and fatigue tests. The results demonstrate that 316L AM parts are weldable, and the tensile and fatigue properties of L-PBF 316L welded components and welded laser cut components are comparable. GMAW-P welding led to lower fatigue results for AM components than for other configurations, but the difference is not important. It was observed that welding defects may have a direct impact on mechanical properties.
Carbonation Resistance of Marine Concrete Containing Nano-SiO2 under the Action of Bending Load
Authors: Zhang Maohua , Tian Zenong , Cui Jiyin
Published: March 2023

In order to study the influence of nanomaterials on the carbonation resistance of marine concrete under bending loads, an appropriate amount of nano-SiO2 was added to plain concrete, and a self-developed carbonation box and bending loading device were used to conduct a coupling test. Four different stress levels were set to measure the carbonation depth of nano-concrete at different ages. Scanning electron microscopy (SEM) and X-ray diffraction (XRD) were used to analyze the concrete interfacial transition zone. The carbonation depth was used as the test index to evaluate the durability of nano-SiO2-based concrete under the combined action of bending load and carbonation. The test results showed that the compressive and flexural strengths of concrete remarkably improved when the nano-SiO2 concentration was 2%. Compared with regular concrete, the compressive and flexural strengths of nano-SiO2 based concrete improved by 15.5% and 15.3%, respectively. When the stress level was 0.15 and 0.6, the carbonation depths of NS20 were 20.5 and 18.4% lower than those of PC in the tensile zone and 18.9 and 23.7% lower than those of PC in the compression zone. The carbonation depth of the NS20 tensile zone was lower by 31 and 18.4% at 3 and 28 days than that of PC. Compared with PC, the carbonation depth in the compression zone of NS20 decreased by 50 and 23.7%, and the carbonation depth of nano-concrete was significantly lower than that of conventional concrete under the same stress level and age. When the stress level is constant, the carbonation depth of the tension zone and compression zone increases gradually with the increase in age, and the carbonation depth of the concrete in the first 7 d was 50% that at 28 days. Under the same age, the carbonation depth in the tension zone increased with increasing stress levels, while the carbonation depth in the compression zone decreased with increasing stress levels. When the stress level was 0.3–0.45, the slope of the carbonation depth curve significantly increased. SEM and XRD analysis results revealed that nano-SiO2 significantly improved the internal structure of concrete by reducing the width of the microcracks, the number of pores, and the number of microcracks. The number of C3S/C2S and CaCO3 crystals in nano-SiO2 based concrete was significantly less than that in plain concrete, and the amount of C-S-H gel was more than that in plain concrete. Under bending loads, the nano-SiO2 significantly improved the carbonation resistance of concrete. When the dosage of nano-SiO2 was 2%, its improvement effect was the most significant.
Analysis of the Influence of Seasonal Water Column Dynamics on the Relationship between Marine Viruses and Microbial Food Web Components Using an Artificial Neural Network
Authors: Ordulj Marin , Šantić Danijela , Matić Frano , Jozić Slaven , Šestanović Stefanija , Šolić Mladen , Veža Jere , Ninčević Gladan Živana
Published: March 2023

Artificial neural network analysis (ANN) is used to study the seasonal distribution of viruses and microbial food web (MFW) components in the open Adriatic Sea. The effect of viruses within the MFW is often overlooked, although viruses play an important role in microbial community dynamics. The results showed that the strongest influence is found in the nonlinear relationship between viruses and temperature. In addition, the algorithm showed that the number of viral populations in the P-limited open sea varies by season and according to the abundance of their main hosts, HB. A strong positive relationship between viruses and HB was found in more than 50% of the observed data. Moreover, this algorithm confirmed the association of the virus with the autotrophic part of the picoplankton and with heterotrophic nanoflagellates. The dynamics of the four resulting clusters, characterized by biological and environmental parameters, is described as a cyclic pattern in the water layer above the thermocline. Neural gas network analysis has been shown to be an excellent tool for describing changes in MFW components in the open Adriatic.
Comparative Study of Potential Flow and CFD in the Assessment of Seakeeping and Added Resistance of Ships
Authors: Sulovsky Ivan , Hauteclocque Guillaume de , Greco Marilena , Prpić-Oršić Jasna
Published: March 2023

The need for maritime freight transport of various goods has never been greater. Consequently, ships are designed with ever-increasing dimensions, with the emphasis, of course, on length. One of the many challenges in the design of large ships is the prediction of their behavior in waves, i.e., motions, and consequently, added resistance. In this paper, a comparative study of two numerical tools for estimating ship motions and added resistance is presented. The first tool is the well-established DNV’s commercial seakeeping code Wasim, a weakly nonlinear potential flow (PF) solver based on a Rankine panel method. The other is the increasingly recognized open-source Computational Fluid Dynamic (CFD) toolkit OpenFOAM®, a viscous flow solver with a turbulence model; it is based on the finite volume method (FVM) combined with a volume-of-fluid (VOF) technique for sea-surface evolution. The study is carried out for two ship seakeeping cases in head-sea regular waves, respectively, without and with ship forward speed. The first case refers to a 6750 TEU containership scale model developed at the LHEEA laboratory in Nantes for a benchmark study, providing experimental data for all test cases. Pitch and heave response is calculated and compared with the experimental values. The second case refers to a KRISO container ship, an extensively researched hull model in ship hydrodynamics. In addition to the pitch and heave, added resistance is also calculated and compared with the experimental values. Hence, it provides a comprehensive basis for a comparative analysis between the selected solvers. The results are systematically analyzed and discussed in detail. For both cases, deterioration of the PF solution with increasing wave steepness is observed, thus suggesting limitations in the modeled nonlinear effects as a possible reason. The accuracy of the CFD solver greatly depends on the spatial discretization characteristics, thus suggesting the need for grid independence studies, as such tools are crucial for accurate results of the examined wave–body interaction scenarios.
On Boundary Conditions for Damage Openings in RoPax-Ship Survivability Computations
Authors: Valanto Petri
Published: March 2023

The survivability of a damaged RoPax ship in the case of a flooding accident can be critical, as these ships have a tendency for a rapid capsize. Various simulation tools are presently in use to study the behavior of damaged RoPax and cruise ships. Recent benchmark tests show that the numerical tools for this purpose are very useful, but their accuracy and reliability still leave something to be desired. In many numerical simulation codes for ship survivability, the water inflow and outflow through a damage opening are modeled with Bernoulli equation, which describes steady flow in an inertial frame of reference. This equation takes neither the floodwater inertia in the opening into account nor does it regard the effect of ship motions on the flow in the opening. Thus, there are some approximations involved in the use of the Bernoulli equation for this purpose. Some alternative formulations are possible. This study sheds light on the question of how relevant is it to use the more complicated formulations instead of the very simple and robust Bernoulli model in the numerical simulation of damaged ships in the sea.
On the Fatigue Strength of Welded High-Strength Steel Joints in the As-Welded, Post-Weld-Treated and Repaired Conditions in a Typical Ship Structural Detail
Authors: Ahola Antti , Lipiäinen Kalle , Lindroos Juuso , Koskimäki Matti , Laukia Kari , Björk Timo
Published: March 2023

Weld quality and life extension methods of welded details in ship structures made of high-strength and ultra-high-strength steels are of high importance to overcome the issues related to the fatigue characteristics of welded high-strength steels. The current work experimentally and numerically investigated the fatigue strength of a longitudinal stiffener detail, typically present in the bulkhead connections of ship hull. Two high-strength steel grades, namely EQ47TM and EQ70QT steels, were studied in welded plate connections using gas metal arc welding with rutile-cored wires. Fatigue tests were carried out on both small-scale specimens under axial and large-scale beam specimens under four-point bending loading. In addition to the joints tested in the as-welded condition, the high-frequency mechanical impact (HFMI) treatment was considered as a post-weld treatment technique in the fatigue test series. Furthermore, the large-scale beam specimens were pre-fatigued until substantial fatigue cracks were observed, after which they were re-tested after weld repairing and post-weld treatments to investigate the potential to rehabilitate fatigue-cracked ship details. The joints in the as-welded condition were performed in accordance with the current design recommendations. Due to the severe transition from the base material to the weld reinforcement in the joints welded with the rutile-cored wire, a successful HFMI treatment required geometrical modification of weld toe using a rotary burr to avoid any detrimental sub-cracks at the HFMI-treated region. Alternatively, the use of solid filler wires could potentially overcome these issues related to the welding quality. Repaired and post-weld-treated welds performed well in the re-tests, and the fatigue strength was almost twice higher than that of tests in the as-welded condition.
An Algorithm of Complete Coverage Path Planning for Unmanned Surface Vehicle Based on Reinforcement Learning
Authors: Xing Bowen , Wang Xiao , Yang Liu , Liu Zhenchong , Wu Qingyun
Published: March 2023

A deep reinforcement learning method to achieve complete coverage path planning for an unmanned surface vehicle (USV) is proposed. This paper firstly models the USV and the workspace required for complete coverage. Then, for the full-coverage path planning task, this paper proposes a preprocessing method for raster maps, which can effectively delete the blank areas that are impossible to cover in the raster map. In this paper, the state matrix corresponding to the preprocessed raster map is used as the input of the deep neural network. The deep Q network (DQN) is used to train the complete coverage path planning strategy of the agent. The improvement of the selection of random actions during training is first proposed. Considering the task of complete coverage path planning, this paper replaces random actions with a set of actions toward the nearest uncovered grid. To solve the problem of the slow convergence speed of the deep reinforcement learning network in full-coverage path planning, this paper proposes an improved method of deep reinforcement learning, which superimposes the final output layer with a dangerous actions matrix to reduce the risk of selection of dangerous actions of USVs during the learning process. Finally, the designed method validates via simulation examples.
An Improved S-Plane Controller for High-Speed Multi-Purpose AUVs with Situational Static Loads
Authors: Jiang Chunmeng , Lv Jinhua , Wan Lei , Wang Jianguo , He Bin , Wu Gongxing
Published: March 2023

The classic S-plane control method combines PD structure with fuzzy control theory, with the advantages of a simple control structure and fewer parameters to be adjusted. It has been proved as a practical method in an autonomous underwater vehicle (AUV) motion control at low and medium speeds, but it takes no account of the situational static load and varying hydrodynamic forces which influence the control quality and even result in a “dolphin effect” at the time of high-speed movement. For this reason, an improved S-plane controller is designed based on the sliding mode variable structure, sliding mode surface, and control items in order to respond to the situational static load and high-speed movement. The improved S-plane controller is verified by Lyapunov stability analysis. The thrust allocation strategies are also discussed with constraints introduced in accordance with task requirements. In order to verify the practicability and effectiveness of the improved S-plane controller, both simulation experiments and field trials of AUV motion control, long-range cruise, and path point following were carried out. The results have demonstrated the superiority of the improved S-plane controller over the classic S-plane controller.
An Improved Method for Optimizing CNC Laser Cutting Paths for Ship Hull Components with Thicknesses up to 24 mm
Authors: Liu Xuan , Chang Daofang
Published: March 2023

In this paper, the essence and optimization objectives of the hull parts path optimization problem of CNC laser cutting are described, and the shortcomings of the existing optimization methods are pointed out. Based on the optimization problem of the hull parts CNC laser cutting path, a new part-cutting constraint rule based on partial cutting is proposed, which aims to overcome the drawbacks of the traditional algorithms with serial cutting constraint rules. This paper addresses the problem of optimizing the path for CNC laser cutting of hull parts, including an empty path and the order and directions used for the provided cut contours. Based on the discretization of the part contour segments, a novel toolpath model for hull parts called hull parts cutting path optimization problems based on partial cutting rules (HPCPO) is proposed in this paper. To solve the HPCPO problem, a segmented genetic algorithm based on reinforcement learning (RLSGA) is proposed. In RLSGA, the population is viewed as an intelligent agent, and the agent’s state is the population’s diversity coefficient. Three different segmented crossover operators are considered as the agent’s actions, and the agent’s reward is related to the changes in the population’s fitness and diversity coefficients. Two benchmark problems for HPCPO were constructed to evaluate the performance of RLSGA and compared with four other algorithms. The results showed that RLSGA outperformed the other algorithms and effectively solved the HPCPO problem.
Coastal Erosion Identification and Monitoring in the Patras Gulf (Greece) Using Multi-Discipline Approaches
Authors: Depountis Nikolaos , Apostolopoulos Dionysios , Boumpoulis Vasileios , Christodoulou Dimitris , Dimas Athanassios , Fakiris Elias , Leftheriotis Georgios , Menegatos Alexandros , Nikolakopoulos Konstantinos , Papatheodorou George , Sabatakakis Nikolaos
Published: March 2023

The primary objective of this research is to demonstrate advanced surveying methods and techniques for coastal erosion identification and monitoring in a densely human-populated coastline, the southern coastline of the Gulf of Patras (Greece), which diachronically suffers erosion problems expected to become worse in the forthcoming years due to climate change and human intervention. Its importance lies in the fact that it presents a robust methodology on how all modern scientific knowledge and techniques should be used in coastal erosion problems. The presented methods include the use of satellite and aerial photo imaging, shallow seabed bathymetry and morphology, sediment sampling, geotechnical investigations, as well as hydrodynamic modelling. The results are extensively analyzed in terms of their importance in coastal erosion studies and are cross-validated to define those areas most vulnerable to erosion. Towards this scope, the seabed erosion rate produced by hydrodynamic modelling is compared with the coastal vulnerability index (CVI) calculations performed in the examined area to identify which coastal zones are under a regime of intensive erosion. The results between the CVI and the seabed erosion rate appear to coincide in terms of the erosion potential, especially in zones where the vulnerability regime has been calculated as being high or very high, with the P. oceanica meadows playing an important role in reducing erosion.
Tubulin Polymerization Promoting Proteins (TPPPs) of Aphelidiomycota: Correlation between the Incidence of p25alpha Domain and the Eukaryotic Flagellum
Authors: Orosz Ferenc
Published: March 2023

The seven most early diverging lineages of the 18 phyla of fungi are the non-terrestrial fungi, which reproduce through motile flagellated zoospores. There are genes/proteins that are present only in organisms with flagellum or cilium. It was suggested that TPPP-like proteins (proteins containing at least one complete or partial p25alpha domain) are among them, and a correlation between the incidence of the p25alpha domain and the eukaryotic flagellum was hypothesized. Of the seven phyla of flagellated fungi, six have been known to contain TPPP-like proteins. Aphelidiomycota, one of the early-branching phyla, has some species (e.g., Paraphelidium tribonematis) that retain the flagellum, whereas the Amoeboaphelidium genus has lost the flagellum. The first two Aphelidiomycota genomes (Amoeboaphelidium protococcorum and Amoeboaphelidium occidentale) were sequenced and published last year. A BLASTP search revealed that A. occidentale does not have a TPPP, but A. protococcorum, which possesses pseudocilium, does have a TPPP. This TPPP is the ‘long-type’ which occurs mostly in animals as well as other Opisthokonta. P. tribonematis has a ‘fungal-type’ TPPP, which is found only in some flagellated fungi. These data on Aphelidiomycota TPPP proteins strengthen the correlation between the incidence of p25alpha domain-containing proteins and that of the eukaryotic flagellum/cilium.