bluuebunny/crossref_metadata_2025 huggingface dataset:
KAJIAN KUAT TEKAN, MODULUS ELASTISITAS, KUAT LEKAT DAN KUAT TARIK BETON MEMADAT SENDIRI TERHADAP BETON NORMAL
Authors: Annisaa Tyas
Published: January 2022

Abstrak

Beton memadat sendiri merupakan sebuah perkembangan teknologi dari beton normal. Kemudahan dalam pekerjaan Beton memadat sendiri disebabkan oleh adanya penambahan admixture berupa superplasticizer. Penambahan superplasticizer dapat berguna untuk mengatur tingkat kekentalan/viskositas beton dengan mengurangi jumlah pemakaian air sampai 30%. Penelitian ini bertujuan untuk menentukan nilai kuat tekan, modulus elastisitas, kuat lekat serta perbandingan kuat tarik langsung dengan kuat tarik belah beton memadat sendiri yang kemudian dibandingkan dengan beton normal. Benda uji yang akan digunakan berjumlah 3 buah untuk masing-masing variasi dengan bentuk dan ukuran yang berbeda pada tiap pengujian, yaitu pengujian kuat tekan dan tarik belah berupa silinder diameter 15 cm dan tinggi 30 cm, pengujian kuat lekat menggunakan batang baja polos diameter 12 mm yang ditancapkan pada silinder diameter 15 cm dan tinggi 30 cm, dan uji kuat tarik langsung berupa balok berukuran 10 x 10 x 25 cm dengan coakan di tengah benda uji. Pengujian dilakukan saat umur beton mencapai 28 hari. Dari pengujian akan didapatkan nilai kuat tekan, modulus elastisitas, kuat lekat serta perbandingan kuat tarik langsung dengan kuat tarik belah beton memadat sendiri dan beton normal. Berdasarkan hasil perhitungan dari pengujian didapatkan bahwa nilai kuat tekan beton memadat sendiri lebih kecil dari beton normal yakni sebesar 28,01 MPa untuk beton SCC dan 30,09 MPa. Pada perhitungan pengujian kuat lekat didapatkan beton memadat sendiri memiliki nilai kuat lekat yang lebih besar daripada beton normal yaitu 0,8431 MPa untuk beton memadat sendiri dan 0,4753 MPa untuk beton normal. Sedangkan untuk pengujian kuat tarik didapatkan f’ct/ct untuk beton memadat sendiri adalah 97% dan 82% untuk beton normal.

 

Kata kunci: beton memadat sendiri, kuat tekan, kuat tarik, kuat lekat.
Analisis Kinerja Simpang Tiga Sriwedari Menggunakan Program Simulasi PTV VISSIM
Authors: Aprilya Sonia
Published: January 2022

Analisis Kinerja Simpang Tiga Sriwedari Menggunakan Program Simulasi PTV VISSIM merupakan penelitian untuk mengatahui kinerja Simpang Tiga Sriwedari menggunakan Program PTV VISSIM dengan mengkalibrasi hasil permodelan menggunakan metode GEH serta memvalidasi hasil permodelan menggunakan Uji T dan Test Perbedaan Relatif.
Analisis Model Simpang Ngapeman Menggunakan Program Simulasi PTV Vissim
Authors: Rizqiah Berlian Fikkriatur
Published: January 2022

Jalan Brigjend Slamet Riyadi merupakan jalan arteri Kota Surakarta dimana terdapat banyak pusat kegiatan di dalamnya. Banyaknya pusat kegiatan pada daerah Central Business District (CBD) mengakibatkan berbagai jenis kendaraan melintasi jalan tersebut. Pada kajian ini dilakukan analisis kinerja Simpang Ngapeman yang merupakan salah satu simpang yang terdapat pada Jalan Brigjend Slamet Riyadi dengan dimodelkan dengan menggunakan program simulasi PTV Vissim. Tujuan dari penelitian ini adalah untuk melakukan mikrosimulasi arus lalu lintas di Simpang Ngapeman pada kondisi mixed traffic dengan melakukan kalibrasi (menggunakan metode GEH untuk volume lalu lintas) dan validasi (menggunakan uji t untuk panjang antrian dan uji perbedaan relatif untuk waktu perjalanan) antara model dan juga kondisi eksisting di lapangan. Hasil dari kajian ini adalah model sudah terkalibrasi nilai GEH kurang dari lima (GEH < 5) dan tervalidasi dengan nilai dari uji t didapatkan t hitung lebih kecil dari t tabel dan P (two tailed) lebih besar dari 0,05 sehingga dapat dikatakan bahwa model pada program simulasi PTV Vissim sudah mendekati kondisi di lapangan.
Kajian Analitik Kinerja Geser Balok Beton Bertulang Menggunakan Response-2000
Authors: Embunsari Mayang Indriana
Published: January 2022

Beton bertulang merupakan bahan bangunan yang penggunaannya semakin meningkat dalam konstruksi. Keruntuhan geser pada beton bertulang dihindari karena sifatnya yang getas dan terjadi secara tiba-tiba. Dengan demikian, diperlukan pemahaman yang baik terkait faktor-faktor yang memengaruhi kinerja geser. Penelitian bertujuan mengidentifikasi kinerja geser pada balok beton bertulang dengan program Response-2000 berbasis Modified Compression Field Theory. Pada tahap awal, verifikasi dilakukan terhadap hasil eksperimen berdasarkan literatur yang ada. Selanjutnya, kajian dikembangkan dengan studi parametrik variasi kuat tekan beton, rasio tulangan lentur dan geser, rasio bentang geser terhadap tinggi efektif, ukuran agregat kasar, dimensi balok, dan kebergantungan waktu. Hasil pemodelan memiliki trend kurva beban-lendutan yang mendekati eksperimen. Selisih persentase beban puncak sebesar 9,21% dan defleksi ultimit sebesar 46,06%, dimana Response-2000 underestimate terhadap nilai defleksi eksperimen. Hasil studi parametrik menunjukkan bahwa peningkatan kuat tekan beton, rasio tulangan lentur dan geser, serta ukuran agregat kasar akan meningkatkan kapasitas geser balok beton bertulang. Sebaliknya, peningkatan rasio bentang geser terhadap tinggi efektif dan dimensi balok (size effect), menunjukkan penurunan kapasitas geser. Perbedaan kapasitas geser ini dipengaruhi oleh kontribusi dari masing-masing komponen yang bekerja dalam mekanisme transfer geser. Studi parametrik pengaruh kebergantungan waktu (susut dan rangkak) terhadap kuat geser balok beton bertulang dipengaruhi kontribusi beton belum retak di zona tekan-lentur dan ikatan antar agregat.
Therapeutic Effects of Ormeloxifene in Cervical Cancer Carcinogenesis
Authors:   ,   University of Tennessee Health Science Center, Chauhan Neeraj
Published: January 2022

Cervical cancer (CxCa) remains the fourth leading cause of cancer related deaths among women worldwide. Cervical cancer is mainly (~ 99.7%) derived from high risk Human papillomavirus (HR HPV). HPV E6/E7 are the two main oncoproteins that interfere with p53 and pRb (retinoblastoma) cell cycle regulatory proteins and hinder their efficacy of controlling cell growth. Additionally, PI3K-Akt is a cell survival pathway that is aberrantly expressed in cervical cancer cells. This pathway has a profound role in inhibiting mitochondrial intrinsic apoptotic signaling pathway. Advanced stage cervical cancer is difficult to treat and patients diagnosed with metastatic disease have a poor survival rate. Therefore, there is an urgent need to develop newer treatment modalities. Ormeloxifene (ORM) is a non-hormonal, anti-estrogen, oral contraceptive for human use. Growing evidences also suggest that ormeloxifene has anti-cancerous properties in a variety of cancers. Developing nanoformulation of drugs has received much attention lately as nanoparticles have site specific targeted drug delivery. Nanoparticles have a specific size range that makes them capable of being entrapped and accumulated at the tumor site due to its leaky vasculature. As a result of it, drug is released from the particle core at a sustained rate; therefore, nanoparticulates offer enhanced bioavailability and better therapeutic efficacy. Considering these benefits, we engineered ormeloxifene loaded PLGA based novel nanoformulation (PLGA-ORM). In this work we validated anti-cancer properties of free ORM and its PLGA based nanoformulation. Our set of data showed that ormeloxifene significantly decreased the cellular proliferation and clonogenic potential of cervical cancer cells. Ormeloxifene also reduced the cellular motility and induced the apoptosis via targeting PI3K-Akt signaling in these cells. Furthermore, ormeloxifene modulated the HPV induced oncogenesis in Caski cells. Ormeloxifene also showed additive inhibitory effects on cellular proliferation and growth when used with radiation. Moreover, our novel PLGA-ORM had a particle size range of 100 – 280 nm and also exhibited excellent encapsulation of ormeloxifene in to PLGA core. PLGA-ORM was labeled with Coumarin 6 (green fluorescent) dye for its uptake studies, where PLGA-ORM internalized in cervical cancer cells in dose, time and energy dependent manner via endocytosis pathway. PLGA-ORM showed improved anti-proliferative/growth properties than free ormeloxifene in cervical cancer cells. When utilized in animals (an orthotopic mouse model) both ormeloxifene and PLGA-ORM showed great anti-tumorous properties, however PLGA-ORM had improved inhibitory effects on tumor growth than free ormeloxifene. To conclude, ormeloxifene and its nanoformulation have the potential to be a novel treatment modality for cervical cancer which can reduce the overall disease burden and improve patients’ life expectancy.
The Role of Exosomal Transport of Viral Agents in Persistent HIV Pathogenesis
Authors:   , Patters Benjamin
Published: January 2022

Human immunodeficiency virus (HIV) infection, despite great advances in antiretroviral therapy (ART), remains a lifelong affliction. Though current treatment regimens can effectively suppress viral load to undetectable levels and preserve healthy immune function, they cannot fully alleviate all symptoms caused by the presence of the virus, such as HIV-associated neurocognitive disorders (HAND). Exosomes are small vesicles that transport cellular proteins, RNA, and small molecules between cells as a mechanism of intercellular communication. Recent research has shown that HIV proteins and RNA can be packaged into exosomes and transported between cells, to pathogenic effect. This review summarizes the current knowledge on the diverse mechanisms involved in the sorting of viral elements into exosomes and the damage those exosomal agents can inflict. In addition, potential therapeutic options to counteract exosomemediated HIV pathogenesis are reviewed and considered.
Living Qur’an as New Market Trends of Islamic Education in Indonesia
Authors: Nurani Shinta , Maulana Luthfi , Purwati Eni
Published: January 2022

This research reviewed living Al-Qur’an as phenomenon and trend in learning Islamic Education in Indonesia. The causing factor is such as the moral panic of parents about modern-contemporary life. Many parents encourage their children to practice the Al-Qur'an, with the hope that the children will be more careful and fortify themselves from a free life. The panicked moral attitude of these parents is used by Islamic educational institutions as a market to gain capital gains, such as establishing an educational house/center based on living Qur'an learning. Several educational institutions also offer the concept of Islamic Boarding School, Tahfidz Center, and compete to use the Al-Qur'an as their product brand. This literature research used a social phenomenological science approach with the living Quran theory. This research found that 1) the trend of living Qur'an education in Islamic learning in Indonesian Islamic educational institutions was as a social impact of the spread of moral panic, 2) moral panic among parents of students became a new business field for managers of Islamic religious education institutions. 3) Al-Qur’an is a product that has its own market share, and 4) the phenomenon of living al-Quran was as a trend of Islamic education methods in Indonesia.
Kepemimpinan Virtual sebagai Alternatif Mempertahankan Budaya Mutu Pondok Pesantren pada Masa Normalitas Baru Pandemi Covid-19
Authors: Agustian Ramadana Putera  , Nurtanio Agus Purwanto  , Muhammad Mulyadi  , Raudatul Jannah
Published: January 2022

Penelitian ini merupakan penelitian kualitatif yang bertujuan untuk menganalisis penerapan kepemimpinan virtual pada lembaga pondok pesantren di Indonesia dalam upayanya mempertahankan budaya mutu di masa normalitas baru pandemi Covid-19. Penelitian ini merupakan penelitian kepustakaan dengan menganalisis sumber-sumber dari penelitian-penelitian terdahulu tentang kepemimpinan virtual dan kaitannya dengan masa pandemi Covid-19. Metode pengumpulan data dilakukan dengan beberapa tahap yaitu penyortiran, pengorganisasian, dan penyuntingan. Setelah data berupa dokumen-dokumen yang dimaksud terkumpul lalu dilakukan analisis data dengan memberikan interpretasi. Hasil dari penelitian ini terbagi menjadi beberapa bagian, antara lain: 1) kepemimpinan yang efektif pada masa dan pasca pandemi Covid-19, 2) kyai dan potensinya memimpin lingkungan virtual, 3) keadaan dan mutu pondok pesantren pasca pandemi Covid-19.
The Commodification of Religion in The 2012 Regional Election of Purwakarta Regency
Authors: Effendi Muhamad Ridwan , Darma Surya Hadi
Published: January 2022

This study aims to describe the involvement of religious instruments in the dynamics of the 2012 Regional Head Elections for the Regent and Deputy Regent of Purwakarta Regency. This study uses a qualitative method with the dramaturgical approach of Erving Goffman on symbolic interactionism and Max Weber on social action theory. This study indicates that the normative use of religious elements is used as a weapon for candidates as a political commodity to attract mass sympathy and highlight the identity of a particular group. Among the religious issues used in the Pilkada Purwakarta could be the use of religious symbols, statements, figures and places used by the contestants and political constituents in Purwakarta.
GESTIÓN Y PRÁCTICAS DE LA RESPONSABILIDAD SOCIAL CORPORATIVA EN AMÉRICA LATINA DURANTE LA PANDEMIA DEL COVID-19
Authors:   Corporación Universitaria Republicana, GODOY MARTHA , VIDAL AIBLIS , CENDALES JUAN , ASUAGUA CAROLINA , CURVELO JOSE
Published: January 2022

The COVID-19 scenario led to new ways of buying, selling, and consuming, a triad that lead to emerging voluntary bets on the part of companies for social, economic, and environmental improvement that legitimizes their actions in the new context. This mentioned process in situations such as confinement, work at home, interaction with diverse teams, and even the transformation of productive practices in the face of the scarcity of raw materials led to a behavioral perspective of corporate social responsibility (CSR) focused on the adaptative capacity of the dynamics of the context. Under this understanding, this research characterizes the management and practices of CSR during the pandemic in Latin America. Methodologically, the 200 best-positioned companies in the Merco Ranking were studied, allowing interaction of companies, leaders, and corporate responsibility and governance. The «social contribution» variable was analyzed with eight crossed variables and contrasted with the information disclosed by the organizations have studied regarding management and CSR practices in the period of the pandemic. The selected countries were Uruguay and Colombia, considering their extreme geographic location on the continent, the disparity in GDP, and the difference in state policies to manage the pandemic. After inferring the research hypothesis, it was possible to determine that the companies studied, despite the territorial disparity, geographical aspects, the number of inhabitants, and separate management of the pandemic, both in Colombia and Uruguay, adopted several measures to face the crisis produced by the COVID-19. Additionally, a social contribution has in both markets has been made, where 92% of Uruguayan companies and 99% of Colombia companies have developed new business models. The mentioned models include digitization of operations, delivery of food baskets and personal hygiene, technological contributions, and among others, donations of supplies and medical pieces of equipment. The companies that contributed the most are located at the top of the ranking in their countries and mostly belong to the industrial sector, a sector that in principle is most affected by the pandemic. In addition, the longest-standing companies made greater contributions. All of those studied presented sustainability reports using international standards and indicators and focused on social and environmental contributions since the beginning of the pandemic.
Projecting Quarantine Utilization During a Pandemic
Authors: Li Wenrui , Kolaczyk Eric D. , White Laura F.
Published: January 2022

Objectives. To develop an approach to project quarantine needs during an outbreak, particularly for communally housed individuals who interact with outside individuals.

Methods. We developed a method that uses basic surveillance data to do short-term projections of future quarantine needs. The development of this method was rigorous, but it is conceptually simple and easy to implement and allows one to anticipate potential superspreading events. We demonstrate how this method can be used with data from the fall 2020 semester of a large urban university in Boston, Massachusetts, that provided quarantine housing for students living on campus in response to the COVID-19 pandemic. Our approach accounted for potentially infectious interactions between individuals living in university housing and those who did not.

Results. Our approach was able to accurately project 10-day-ahead quarantine utilization for on-campus students in a large urban university. Our projections were most accurate when we anticipated weekend superspreading events around holidays.

Conclusions. We provide an easy-to-use software tool to project quarantine utilization for institutions that can account for mixing with outside populations. This software tool has potential application for universities, corrections facilities, and the military. (Am J Public Health. 2022;112(2):277–283. https://doi.org/10.2105/AJPH.2021.306573 )
Science Translation During the COVID-19 Pandemic: An Academic-Public Health Partnership to Assess Capacity Limits in California
Authors: Maldonado Peter , Peng Angie , Ouyang Derek , Suckale Jenny , Ho Daniel E.
Published: January 2022

On the basis of an extensive academic–public health partnership around COVID-19 response, we illustrate the challenge of science-policy translation by examining one of the most common nonpharmaceutical interventions: capacity limits. We study the implementation of a 20% capacity limit in retail facilities in the California Bay Area.

Through a difference-in-differences analysis, we show that the intervention caused no material reduction in visits, using the same large-scale mobile device data on human movements (mobility data) originally used in the academic literature to support such limits. We show that the lack of effectiveness stems from a mismatch between the academic metric of capacity relative to peak visits and the policy metric of capacity relative to building code.

The disconnect in metrics is amplified by mobility data losing predictive power after the early months of the pandemic, weakening the policy relevance of mobility-based interventions. Nonetheless, the data suggest that a better-grounded rationale for capacity limits is to reduce risk specifically during peak hours. To enhance the connection between science, policy, and public health in future times of crisis, we spell out 3 strategies: living models, coproduction, and shared metrics. (Am J Public Health. 2022;112(2):308–315. https://doi.org/10.2105/AJPH.2021.306576 )
Developing a Case Investigation and Contact-Tracing System in Puerto Rico, 2020
Authors: Soto-Canetti Gabriela , García Lizmara , Juliá Andrés E. , Gordián Eva I. , Bartolomei José A. , Camareno Nilsa , Rodríguez José F. , Montoya Martín
Published: January 2022

We present a record of events that led to the creation of the Puerto Rico Case Investigation and Contact-Tracing System (CICTS) to monitor and control the spread of severe acute respiratory syndrome coronavirus 2 in Puerto Rico. The development of the CICTS is a significant step toward establishing a comprehensive infectious disease surveillance system in Puerto Rico. Furthering the development of a CICTS infrastructure is critical in the response against future emerging infectious diseases in the region. (Am J Public Health. 2022;112(2):223–226. https://doi.org/10.2105/AJPH.2021.306584 )
Targeting Equity in COVID-19 Vaccinations Using the “Evaluating Vulnerability and Equity” (EVE) Model
Authors: Weston Benjamin W. , Swingen Zachary N. , Gramann Shannon , Pojar Dan
Published: January 2022

The COVID-19 pandemic has highlighted racial and ethnic disparities, most recently in vaccine administration. The EVE (Evaluating Vulnerability and Equity) Model combines a community’s vulnerability with vaccination rates to enhance the equity of vaccine distribution in an intentional, targeted manner. When applied to Milwaukee County, Wisconsin, two extreme categories of vaccination status were identified to aid in resource allocation and messaging: populations with high vulnerability and low vaccination levels, and, conversely, those with low vulnerability and high vaccinations levels. (Am J Public Health. 2022;112(2):220–222. https://doi.org/10.2105/AJPH.2021.306585 )
Popularity of Delta-8 THC on the Internet Across US States, 2021
Authors: Livingston Melvin D. , Walker Andrew , Cannell Michael B. , Rossheim Matthew E.
Published: January 2022

Objectives. To assess the popularity of an emergent drug, delta-8 tetrahydrocannabinol (THC), and compare interest levels between US states with or without legalized recreational cannabis.

Methods. We used Google Trends to assess the growth of interest among delta-8 THC–related search terms from May 17, 2020, to May 9, 2021. We examined differences between states with or without legalized cannabis using state-level Google Trends data from February 13 to May 13, 2021, and policy data from the National Conference of State Legislatures.

Results. Interest in delta-8 THC increased starting in mid-June 2020, with search volumes for delta-8 THC queries currently at 35% of the “marijuana” query. States where recreational cannabis is illegal had higher relative queries than did states with legalized recreational cannabis (52.3 vs 14.8; t = 40.9; P < .001).

Conclusions. There has been rapid growth in interest in delta-8 THC. Findings between state policy contexts likely indicate delta-8 THC’s role as a substitute good for delta-9 THC.

Public Health Implications. Digital signals such as search volumes may point to an emergent use trend in the substance delta-8 THC. Further studies are needed to assess potential harms and correlates of delta-8 THC use. (Am J Public Health. 2022;112(2):296–299. https://doi.org/10.2105/AJPH.2021.306586 )
Bilateral Extensor Mechanism Allograft Reconstruction in Native Knees
Authors: DePalma Brian J. , Costales Timothy G. , Schneider Matheus B. , Henn R. Frank
Published: January 2022

Case:

A 66-year-old man presented with chronic bilateral extensor mechanism dysfunction and profound patella baja after failed revision surgery for bilateral quadriceps tendon ruptures. Staged bilateral reconstruction with complete extensor mechanism allograft resulted in excellent two-year satisfaction and clinical outcomes.

Conclusion:

Complete extensor mechanism reconstruction can be a successful treatment for chronic quadriceps tendon rupture with profound patella baja.
Multidisciplinary Approach to Multiple Multiresistant Agent Infection of Instrumented Spine Surgery
Authors: Xará-Leite Francisco , Ribau Ana , Lopes Guerra Mário Diogo , Abreu Miguel Araújo , Rodrigues-Pinto Ricardo
Published: January 2022

Case:

We report the case of a patient with consecutive infections with several multidrug-resistant agents—including carbapenem-resistant strains of Klebsiella pneumoniae among others—from a surgical wound infection after lumbar spine fusion, only successfully treated after the resort to novel antibiotics (ceftazidime-avibactam) in combination therapy.

Conclusions:

Multidrug resistance has become a major challenge in today’s medicine. Care should be taken to avoid their emergence, but when present, a multidisciplinary approach is mandatory to ensure clinically up-to-date treatment choices. Multimodal antibiotic schemes tend to show the most promising results, with which successful infection resolution can still be achieved.
Midfoot Derotational Osteotomy for Ankylosing Inversion Deformity in Patients with Rheumatoid Arthritis
Authors: Etani Yuki , Hirao Makoto , Ebina Kosuke , Kunugiza Yasuo , Noguchi Takaaki , Tsuboi Hideki , Tsuji Shigeyoshi , Okada Seiji , Hashimoto Jun
Published: January 2022

Case:

Ankylosing midfoot inversion deformities in 3 patients with rheumatoid arthritis (RA) treated by midfoot derotational osteotomy to remove the pain due to excessive loading of the fifth metatarsal base and to obtain the plantigrade position are presented. All cases achieved sufficient correction and good clinical and radiographic improvement.

Conclusion:

Midfoot derotational osteotomy seems useful and has the possibility to be a definitive surgical procedure for ankylosing inversion deformity in patients with RA. Osteotomy should be performed from both medial and lateral sides, and careful retraction of soft tissues should always be kept in mind.
Group Counseling With Choice Theory To Increase Student Achievement Motivation
Authors: Ansyah Eko Hardi
Published: January 2022

The Student Achievement Motivation is an encouragement of student to obtain the learning achievement. The low of this motivation can affect the low of learning achievement. In consequence, it required an effort to improve this achievement motivation. The Group Counseling represent counseling that utilizing group to teach the client about how to think, plan, and behave effectively which is hypothesized could improve the student achievement motivation. This research aims to know the effectiveness of group counseling with choice thery to improve the student achievement motivation. This research is conducted by experimental design to 18 students with low learning achievement. The subjects were divided into two groups, that is, control and experimental group. In control group, researcher doesn't give the treatment. In experimental group, the researcher give the treatment in the form of group counseling with choice theory. Data analyzed for the result of student achievement tha conducted in pretest and posttest with covarian analysis. The result shows that there is different between control and experimental group with F(2,15) = 5,545; p = 0,033; p < 0,05; n2 = 0,27, so hypothesis that there is different between the student achievement motivation with low learning achievement based on participation in group counseling with choice theory is accepted. Thereby, the group counseling with choice theory treatment is proven to improve the student achievement with low learning motivation in experimental group. This treatment contribution to improve the student achievement motivation with low learning achievement is about 27%. So that this treatment could be conducted to solve the low learning achievement student.
SEFT® Therapy (Spiritual Emotional Freedom Technique) To Reduce The Tendency To Smoking In Early Adolescents
Authors: Mariyati Lely Ika , Habibah Nur
Published: January 2022

SEFT® therapy was given to maximize the effectivity of the body energy system which used the EFT technique (tapping) with spiritual power (pray and surrender). The aim was stabling mind and feeling in order to positivy  the self concept and the self control of early adolescent.  This research was quantitative experimental approach with pretest-posttest one group design.  The variable was SEFT® therapy as the independ ent variable and the smoking prefference as the dependent variable.  The sampling technique was cluster random sampling gotten two Yunior High School in Waru region and random assignment gotten twelve students as experimental group research. The instruments data collection was the prefference smoking scale.  The data was, analyzed by Wilcoxon Mathch Pairs Test,with SPSS 16 program, gotten ( p = 0,004; p<0,01), it was meant that there was the differences between the smoking prefference on early adolescents before and after given SEFT® therapy.  The difference of smoking prefference was seen from the average posttest was lower than pretest (49 < 60), the result of follow up average was lower than the posttest (41 < 49).  The result of the research showed that SEFT® therapy able to decerase the smoking prefference of early adolescents.
In situ visualization with temporal caching
Authors: DeMarle David , Bauer Andrew
Published: January 2022

In situ visualization is a technique in which plots and other visual analyses are performed in tandem with numerical simulation processes in order to better utilize HPC machine resources. Especially with unattended exploratory engineering simulation analyses, events may occur during the run, which justify supplemental processing. Sometimes though, when the events do occur, the phenomena of interest includes the physics that precipitated the events and this may be the key insight into understanding the phenomena that is being simulated. In situ temporal caching is the temporary storing of produced data in memory for possible later analysis including time varying visualization. The later analysis and visualization still occurs during the simulation run but not until after the significant events have been detected. In this article, we demonstrate how temporal caching can be used with in-line in situ visualization to reduce simulation run-time while still capturing essential simulation results.
Reliability of Pictorial Longshi Scale for Informal Caregivers to Evaluate the Functional Independence and Disability
Authors: Liu Xiangxiang , Gao Yan , Zhao Jingpu , Zhou Mingchao , Wan Li , Nie Guohui , Wang Yulong
Published: January 2022

Background: Numerous instruments to evaluate the functional independence and disability are available for healthcare professionals, making it difficult for patients and their families to evaluate and explain the results. Longshi Scale is the first pictorial-based disability assessment tool and it may allow a much simply and inclusive assessment across all population. The objective of this study was to test the reliability of the Longshi Scale for informal caregivers to assess functional independence and disability. Methods: This study was conducted at the inpatient rehabilitation departments from 24 hospitals in 11 cities across China. The patients who were more than 18 years old and diagnosed with cerebral infarction, cerebral hemorrhage, brain trauma, spinal cord injury, postoperative brain tumors, and other disorders causing physical functional disabilities were recruited. Then the Longshi Scale was used to assess the functional independence and disability of patients by both healthcare professionals and informal caregivers. Descriptive statistics (i.e., frequency, percentage, mean, and standard deviation) were calculated. The Kolmogorov-Smirnov test was used to examine the normal distribution of the data. The chi-square test or McNemar-Bowker test was used to compare the nominal variables of the three groups. T‑tests were used to compare the mean of the quantitative variables of the two groups. The agreement between the scores was assessed using Cohen’s kappa statistic and the marginal homogeneity test. Results: In total of 947 patients were included. Of these, 419 were in the “bedridden group”, 298 in the “domestic group”, and 230 in the “community group”. The mean scores were 5.00±1.936, 5.37±1.656 and 7.18±2.055 in the bedridden, domestic, and community groups, respectively. The mean score of each item was compared, and there were no significant differences between healthcare professionals and informal caregivers (p > 0.05). The Longshi Scale items and the sum score had fair or better agreement (weighted kappa > 0.50) between healthcare professionals and informal caregivers’ scores. The reliability of Longshi Scale was found to be acceptable.Conclusions: This study demonstrated fair or better agreement between healthcare professionals’ and informal caregivers’ scores on Longshi Scale items and their sum scores. The Longshi Scale for the assessment of the functional independence and disability by informal caregivers, is reliable.Trail registration: ChiCTR2000040556.
Quality of life after salvage surgery for extensively recurrent head and neck cancer patients: a prospective, observational, real-world study
Authors: Zhang Lirui , Liu Huan , Li Bo , Li Jinzhong , Wang Hao , Yang Bin , Qin Lizheng , Han Zhengxue , Feng Zhien
Published: January 2022

Purpose

Multiple studies on salvage surgery (SS) implied the efficacy but the estimate of quality of life (QOL) after SS was poorly analyzed. Our study aimed to examine the quality of life before and after salvage surgery using the validated instruments QLQ-H&N35 and UW-QOL and investigate the value of salvage surgery by quantifying survival outcomes.
Materials and methods

Among 21 patients, preoperative and postoperative QOL were accessed using QLQ-H&N35 and UW-QOL questionnaire. Patients’ demographic characteristics, history of treatment, recurrent tumor characteristics, salvage surgery details and follow-up date were abstracted from our prospective database. Statistical analysis methods included Wilcoxon signed-rank test, descriptive analysis and Kaplan-Meier method.
Results

The overall quality of life was significantly improved after salvage surgery. Pain was significantly relieved whilst diminished functions were hinted with significant differences in UW-QOL domains swallowing, chewing, speech, shoulder, taste, saliva and in QLQ-H&N35 domains swallowing, speech, social eating, senses, dry mouth, sticky saliva as p༜0.05. The median disease-free survival of whole 21 patients was 5 months (range 0-73) and the median overall survival was 13 months (range 1-73).
Conclusions

The quality of life after salvage surgery for extensively recurrent head and neck cancer is acceptable. Despite the dysfunctions such as dysphagia and dry mouth, it does relieve the pain and improve the short-term overall QOL of patients. Further studies on quality of life before and after salvage surgery in HNSCC are obviously needed. In the future, postoperative functional recovery training also needs attention during follow up.
GM-CSF Promotes Immune Response and Survival in a Mouse Model of COVID-19
Authors: Kendall Lon , Boyd Timothy , Sillau Stefan , Bosco-Lauth Angela , Markham Neil , Fong Derek , Clarke Penny , Tyler Kenneth , Potter Huntington
Published: January 2022

COVID-19 results in increased expression of inflammatory cytokines, but inflammation-targeting clinical trials have yielded poor to mixed results. Our studies of other disorders with an inflammatory component, including Alzheimer’s disease, chemobrain, Down syndrome, normal aging, and West Nile Virus infection, showed that treatment with the ‘pro-inflammatory’ cytokine granulocyte-macrophage colony stimulating factor (GM-CSF) in humans or mouse models alleviated clinical, behavioral, and pathological features. We proposed that human recombinant GM-CSF (sargramostim) be repurposed to promote both the innate and adaptive immune responses in COVID-19 to reduce viral load and mortality1. Here, we report the results of a placebo-controlled study of GM-CSF in human ACE2 transgenic mice inoculated intranasally with SARS-CoV2 virus, a model of COVID-19. Infection resulted in high viral titers in lungs and brains and over 85% mortality. GM-CSF treatment beginning one day after infection increased anti-viral antibody titers, lowered mean lung viral titers proportionately (p=0.0020) and increased the odds of long-term survival by up to 5.8-fold (p=0.0358), compared to placebo. These findings suggest that, as an activator of both the innate and adaptive immune systems, GM-CSF/sargramostim may be an effective COVID-19 therapy with the potential to protect from re-infection more effectively than treatment with antiviral drugs or monoclonal antibodies.
MicroRNA-32-5p Inhibits Metastasis By Directly Targeting VPS4B and Increases Sensitivity to Dihydroartemisinin in Neuroblastoma
Authors: Chen Lina , Liu Hui , Zheng Zhongyuan , Wang Xi , Qu Shuiqing , Yang Yuanmin , Deng Shuoqiu , Zhang Yu , Liu Tuo , Cui Honghua , Li Yujie
Published: January 2022

Neuroblastoma (NB) is a malignant pediatric tumor requiring new treatments. Accumulating evidence has confirmed that microRNAs (miRNAs) have a major effect on NB metastasis. The present study aimed to characterize a novel miRNA, miR-32-5p, by exploring its expression, function, as well as action mechanism in NB metastasis. Real-time quantitative polymerase chain reaction (qRT-PCR) as well as Western blotting was utilized to measure the expression of miR-32-5p and its target-vacuolar protein sorting 4B (VPS4B). Transwell assay was conducted to test the cell migration as well as its invasion in vitro, and the metastasis xenograft model of nude mice was set up by injections through the caudal vein in vivo. In comparison with the normal tissue and cell line, the miR-32-5p expression showed a marked downregulation in human NB samples and cell lines. Furthermore, the miR-32-5p upregulation suppressed NB cell metastasis in culture and the tumor xenograft model. Although in NB cell lines, VPS4B was found to be miR-32-5p’s direct target, its overexpression would reverse miR-32-5p’s suppressive effects. Moreover, miR-32-5p increased the sensitivity to dihydroartemisinin in neuroblastoma. The current outcomes implicated that the axis of miR-32-5p/VPS4B can be NB metastasis’s novel therapeutic target.
Synthesis of TiO2/g-C3N4 photocatalyst with recovered TiO2 from spent SCR catalyst for photodegrading Rhodamine B
Authors: Li Min , CHANG Zhidong , Dang Hui , Ma Sihang , Li Wenjun
Published: January 2022

Purpose TiO2 recovered from spent SCR catalyst, a hazardous industrial solid waste, was modified by g-C3N4 to produce the recovered TiO2 (R-TiO2) /g-C3N4 photocatalyst to protect valuable Ti resources and revamp its shortage of underutilization of visible light. Methods The R-TiO2 which was obtained from spent SCR catalyst by alkali leaching method was used to prepare the R-TiO2/g-C3N4 photocatalyst via self-assembly procedure. The photodegradation efficiencies of the prepared samples were evaluated by degradation of Rhodamine B (RhB) under visible light.Results The XRD patterns indicate that R-TiO2 remains the crystal structure of standard anatase TiO2 phase intact all along in recovery process. The photodegradation efficiency of the R-TiO2/g-C3N4 photocatalyst evaluated by degradation of RhB under visible light optimally reached 97.11% when the system was irradiated for only 40 min. For comparison, the best RhB degradation rate constant from the R-TiO2/g-C3N4 photocatalyst was about 1.9 times that of the pure TiO2/g-C3N4 photocatalyst. Conclusion The results demonstrate that the TiO2/g-C3N4 photocatalyst with recovered TiO2 from spent SCR catalyst show excellent photodegradation efficiency for RhB. Moreover, the RhB degradation efficiency over the R-TiO2/g-C3N4 photocatalysts are superior to pure TiO2/g-C3N4 photocatalysts.
Double-Bilayer Polar Nanoregions and Mn antisites in (Ca,Sr)3Mn2O7
Authors: Miao Leixin , Hasin Kishwar-E , Moradifar Parivash , Mukherjee Debangshu , Wang Ke , Cheong Sang-Wook , Nowadnick Elizabeth , Alem Nasim
Published: January 2022

The layered perovskite Ca3Mn2O7 (CMO) is a hybrid improper ferroelectric (HIF) candidate proposed for room temperature multiferroicity, which also displays negative thermal expansion behavior due to a competition between coexisting polar and nonpolar phases. However, little is known about the atomic-scale structure of the polar/nonpolar phase coexistence, or the underlying physics of its formation and transition. In this work, we report the first direct observation of double bilayer polar nanoregions (db-PNRs) in Ca2.9Sr0.1Mn2O7 using aberration-corrected scanning transmission electron microscopy (S/TEM). In-situ TEM heating experiments show that the db-PNRs can exist up to 650°C. Electron energy loss spectroscopy (EELS) studies coupled with first-principles calculations demonstrate that the stabilization mechanism of the db-PNRs is directly related to a Mn oxidation state change (from 4+ to 2+), which is linked to the presence of Mn antisite defects. These findings open the door to manipulating phase coexistence and achieving exotic properties in HIFs.
Early circulating strain of SARS-CoV-2 causes severe pneumonia distinct from that caused by variants of concern
Authors: Matsumoto Yusuke , Yasui Fumihiko , Endo Akinori , Sanada Takahiro , Munakata Tsubasa , Takagi Asako , Yamaji Kenzaburo , Yamamoto Naoki , Saeki Yasushi , Kohara Michinori
Published: January 2022

To analyze the molecular pathogenesis of SARS-CoV-2, a small animal model such as mice is needed: human ACE2, the receptor of SARS-CoV-2, needs to be expressed in the respiratory tract of mice. We conferred SARS-CoV-2 susceptibility in mice by using an adenoviral vector expressing hACE2 driven by an EF1α promoter with a leftward orientation. In this model, severe pneumonia like human COVID-19 was observed in SARS-CoV-2-infected mice, which was confirmed by dramatic infiltration of inflammatory cells in the lung with efficient viral replication. An early circulating strain of SARS-CoV-2 caused the most severe weight loss when compared to SARS-CoV-2 variants of concern, although histopathological findings, viral replication, and cytokine expression characteristics were comparable. We found that a distinct proteome of an early circulating strain infected lung characterized by elevated complement activation and blood coagulation, which were mild in other variants, can contribute to disease severity. Unraveling the specificity of early circulating SARS-CoV-2 strains is important in elucidating the origin of the pandemic.
Acute Myeloid Leukaemia Induces Natural Killer Cell Exhaustion through Inhibition of the PI3K-AKT Pathway
Authors: Zhao Xiang-Yu , Liu Xue-Fei , Liu Long , Yu Xing-Xing , Fan Ze-Ying , Shang Qian-Nan , Chang Yingjun , Zhao Xiao-Su , Wang Yu , Xu Lan-Ping , Zhang Xiao hui , Liu Kai-Yan , Huang Xiaojun
Published: January 2022

Natural killer (NK) cell exhaustion is associated with a poor prognosis in persistent infection and cancer. Determination and understanding of the mechanism of NK cell exhaustion in acute myeloid leukaemia (AML) patients may provide underlying principles for enhancing AML therapy. We investigated NK cell exhaustion in relapsed AML patients post allogeneic haematopoietic stem cell transplantation (allo-HSCT) based on phenotypic, functional, and RNA-sequencing (RNA-seq) analyses. Compared with those from the complete remission control (N=30) and healthy control (N=12) groups, NK cells from the relapsed group (N=30) were less mature, with a large CD56bright subset, high NKG2A expression, poor cytotoxicity, downregulation of the transcription factors Eomesodermin (EOMES) and T-bet, and cell cycle arrest in the G1 stage. NK cell exhaustion could be reversed once relapsed patients achieved remission. Furthermore, NK cells showed high NKG2A expression but normal cytotoxicity in minimal residual disease (MRD)-positive patients post allo-HSCT. Combined with in vitro and mouse model results, the data suggested that NK cell exhaustion was induced by persistent AML stimulation. Moreover, RNA-seq and western blot analyses showed that the phosphatidylinositol-3-kinase (PI3K)-AKT inhibition in exhausted NK cells was induced by AML and that PI3K-AKT activators could reverse NK cell exhaustion in vitro. Consequently, our studies highlight that AML induces NK cell exhaustion through the PI3K-AKT pathway.
Patterns of sexual and HIV-related stigma among MSMW living with HIV in Haiti: Experiences, impact on mental health, and coping mechanisms
Authors: Dévieux Jessy G. , Vertovec John , Jean-Gilles Michèle , Rosenberg Rhonda , René Cassandra , Cyrus Elena , Jean Samuel Emieux , Dunbar Willy
Published: January 2022

Vulnerability to contracting HIV among Men who have Sex with Men and Women (MSMW) was recognized early in the epidemic. However, while global HIV efforts have made tremendous progress for the general population, the specific needs of MSMW were not directly addressed with tailored and context-adapted interventions. The purpose of this study was to inform this area of research by exploring patterns of stigma through sexual identity developmental history as well as coping mechanisms among MSMW living with HIV in Haiti. A qualitative descriptive study comprised of in-depth interviews with 32 MSMW living with HIV was carried out. Participants were recruited using snowball techniques. An inductive thematic analysis was conducted in NVivo, guided by the socio-ecological context of Haiti. MSMW reported struggling with their sexuality since their adolescence, often because of enacted stigma from family members, the community, and cultural conflicts. Most participants described experiencing anxiety, psychological distress, depression, social isolation, suicidal ideation and suicide attempts. Mechanisms for coping with stigma included self-acceptance, social support, hiding their sexual orientation, and tolerance of the voodoo religion. To combat stigma, and improve HIV treatment adherence and retention among MSMW, culturally-tailored multilevel initiatives should be implemented, including cognitive-behavioral interventions to reduce self-blame and shame while improving social support and linkage to supportive organizations and social networks.
Public clay pot waters: a hidden risk for diarrheal diseases transmission in a cholera endemic area of Cameroon
Authors: Djaouda Moussa , Nougang Mireille Ebiane , Ldingté Jean Dékouché , Thélé Frédérique Demgodéré , Bouba Roméo Wakayansam , Dawaye Daniel Amani , Togouet Serge Hubert Zébazé , Liang Song , Nola Moïse
Published: January 2022

Maroua, the capital of Far North Cameroon, is frequently affected by outbreaks of waterborne diseases. Waters stored through public clay pots are common in the city and provided voluntarily by individuals for drinking and ablution. Yet, such service through the clay pots and the stored water lacks management and surveillance. If contaminated, such water may pose infection and transmission risks of waterborne diseases among the population. The water quality of 95 randomly selected public clay pots was assessed through isolation and count of Total Coliforms (TCs) and Escherichia coli. Also analyzed was the bacteriological quality of the water source (borehole or tap) for comparison. For each clay pot, physical characteristics and management information were documented and potential sources of contamination were identified. Results showed that the concentration of TCs ranged from 0 CFU/100 mL in tap water to 160 CFU/100 mL in borehole water. The concentrations of E. coli varied from 0 CFU/100 mL in tap water to 2 CFU/100 mL in borehole water. Depending on the source of water supply and the neighborhood, the concentrations of total coliforms increased significantly in clay pots during water storage in most neighborhoods (P<0.05). Poor management and hygiene were responsible for water contamination.