bluuebunny/crossref_metadata_2025 huggingface dataset:
Expectations of new technologies in nursing care among hospital patients in Germany – an interview study
Authors: Klawunn Ronny , Albrecht Urs-Vito , Dierks Marie-Luise
Published: September 2023

Introduction

New technologies will be increasingly available for nursing care, including robots, patient mobilisation devices, digital event detection or prevention equipment. Technologies are expected to support nurses, increase patients’ safety and reduce costs. Yet, although these technologies will significantly shape patients’ experience, we need to learn more about patients’ perspectives regarding new technology in care. This study aims to investigate attitudes, expectations, worries and anticipated implementation effects of new assistive technology in nursing care by patients.

Methods

Qualitative, guided, semi-open interviews were conducted. The recruitment was carried out in a trauma surgery ward of a university hospital in Germany. Eight different technologies were presented via video clips and additional information to the patients, followed by in-depth discussions. The interviews were analysed using qualitative evaluative content analysis. The Consolidated Criteria for Reporting Qualitative Research (COREQ) Checklist was used to ensure study quality.

Results

Study participants anticipate different outcomes for the implementation of new nursing technology: (1) For patients, they consider the potential for improvement in health and well-being as well as for their hospital stay experience, but also fear possible health risks or social or emotional factors like loss of autonomy or loneliness. (2) For professional nurses, participants expect relief from physically stressful work routines; however, they might be replaced by machines and lose their employment (3) For the nursing process, safety and quality improvements for care delivery may encounter a negative quantification of human life and risks of constant surveillance.

Conclusion

Patients identify opportunities, challenges and shortcomings of nursing technology implementation. They describe nuanced and mixed accounts of patients’ perspectives that are structured in a ‘continuum of anticipated effects’ of implementing technology in our article. The results can inform future implementation strategies.
Attitudes and intentions toward seeking professional psychological help among Chinese healthcare workers during the COVID-19 pandemic
Authors: Huang Ruirui , Peng Xiaoyan , Yu Shuai , Tian Yumei , Gao Chuanying
Published: September 2023

Background

It has been suggested that healthcare workers (HCWs) are experiencing massive stressors that threaten their mental health during the COVID-19 pandemic, but little is known about their attitudes and intentions toward seeking professional psychological help. This study aimed to investigate the attitudes and intentions of Chinese HCWs toward seeking professional psychological help during the COVID-19 pandemic and the associated factors.

Methods

A total of 1,224 Chinese HCWs working in hospitals were recruited online from 12 hospitals in Hunan province in China for a survey conducted in November 2022. The Chinese version of the attitudes toward seeking professional psychological help scale-short form (ATSPPH-SF) and the general help-seeking questionnaire (GHSQ) were separately used to assess the attitudes and intentions of the respondents toward seeking professional psychological help. Demographic and socio-psychological data were collected using a self-developed questionnaire, the perceived social support scale, the self-stigma of seeking help scale, and the patient health questionnaire-9 scale.

Results

The 1,208 HCWs in the final analysis showed relatively negative attitudes and low intentions toward seeking professional psychological help during the COVID-19 pandemic. Results of the multiple linear regression analysis showed that female sex (p = 0.031), experience of psychological learning (p < 0.001), and social support (p < 0.001) had a positive predictive effect on the attitudes of these HCWs toward seeking professional psychological help, whereas self-stigma of seeking help (p < 0.001) and depressive symptoms (p < 0.001) exerted negative effects. Moreover, experience of psychological learning (p = 0.004) and social support (p < 0.001) had a positive predictive effect on the intentions of these HCWs toward seeking professional psychological help, whereas divorced marital status (p = 0.011) and self-stigma of seeking help (p < 0.001) exerted negative effects.

Conclusion

The overall attitudes and intentions of HCWs toward seeking professional psychological help were not optimistic. Effective interventions targeted at influencing factors should be formulated to promote the professional psychological help-seeking attitudes and intentions of HCWs who are at risk of developing mental health problems.
Impact of desert dust storms, PM10 levels and daily temperature on mortality and emergency department visits due to stroke
Authors: Oktay M. Murat , Al Behcet , Boğan Mustafa , Kul Seval , Gümüşboğa Hasan , Bayram Hasan
Published: September 2023

Objective

It is known that the inhalation of air pollutants adversely affects human health. These air pollutants originated from natural sources such as desert storms or human activities including traffic, power generating, domestic heating, etc. This study aimed to investigate the impacts of desert dust storms, particulate matter ≤10 μm (PM10) and daily maximum temperature (MT) on mortality and emergency department (ED) visits due to stroke in the city of Gaziantep, Southeast Turkey.

Method

The data on mortality and ED visits due to stroke were retrospectively recruited from January 1, 2009, to March 31, 2014, in Gaziantep City Centre.

Results

PM10 levels did not affect ED visits or mortality due to stroke; however, MT increased both ED visits [adjusted odds ratio (OR) = 1.002, 95% confidence interval (CI) = 1.001–1.003] and mortality (OR = 1.006, 95% CI = 0.997–1.014) due to stroke in women. The presence of desert storms increased ED visits due to stroke in the total population (OR = 1.219, 95% CI = 1.199–1.240), and all subgroups. It was observed that desert dust storms did not have an increasing effect on mortality.

Conclusion

Our findings suggest that MT and desert dust storms can induce morbidity and mortality due to stroke.
When There is No Guidance From the Guidelines: Renal Transplantation in Recipients With Class III Obesity
Authors: Gillespie Hannah , O’Neill Stephen , Curtis Rebecca M. K. , Callaghan Chris , Courtney Aisling E.
Published: September 2023

Whilst renal transplantation is the optimal treatment for many patients with end-stage kidney disease, the latest international guidelines are unable to make recommendations for the management of patients with end-stage kidney stage kidney disease and Class III Obesity (BMI ≥40 kg/m2). Data on all adult patients receiving a kidney-only-transplant in the UK between 2015–2021 were analysed from a prospectively collected database and interrogated across a range of parameters. We then analysed in detail the outcomes of patients transplanted at the highest-volume unit. There were 22,845 renal transplants in the study time-period; just 44 (0.2%) were performed in recipients with a BMI ≥40 kg/m2. Most transplant centres did not transplant any patients in this category. In the centre with the highest volume, there were 21 transplants (9 living donor) performed in 20 individuals (13 male, median age 46 years). One-year patient and death-censored graft survival was 95% and 85%. Successful transplantation is possible in patients with BMI ≥40 kg/m2 but carries additional risk. Obesity should not be the sole factor considered when deciding on transplant suitability. Restricting transplantation to a small number of high-volume centres in each country should be considered to optimize outcomes.
The Acoustic Characteristics of Hellenistic Morgantina Theatre in Modern Use
Authors: Amadasi Giovanni , Bevilacqua Antonella , Iannace Gino , Trematerra Amelia
Published: September 2023

Thousands of theatres were built during the Hellenistic period in Greece and overseas colonies. The main elements of the Hellenistic theatre are the following: the orchestra, where music and songs were performed to accompany the acting performance, and the koilon, where the audience sat. Hellenistic theatres were built without any ceiling, with an open-air configuration. This paper reports the acoustic characteristics of the Greek (Hellenistic) theatre located in Morgantina (Sicily, Italy) based on the technical data gathered in different listening positions selected across the sitting area (koilon). The theatre of Morgantina was built in the third century BC and renovated a few decades ago. Nowadays, it is the center of important social and cultural activities. The outcomes of the beamforming technique employed for the survey have been discussed in comparison with traditional acoustic parameters, such as ISO 3382. The scope of this article is to assess the usability of this theatre intended to be used for different types of artistic performances.
The Development and Application of Two-Color Pressure-Sensitive Paint in Jet Impingement Experiments
Authors: Chen Wei-Chieh , Huang Chih-Yung , Tan Kui-Thong , Sakaue Hirotaka
Published: September 2023

This study aimed to develop a two-color pressure-sensitive paint (PSP) that has both high pressure sensitivity and high temperature sensitivity. Different nitrobenzoxadiazole (NBD) derivatives were used as the temperature probe. Among them, NBD-ZY37 demonstrated favorable stability against photodegradation, and its temperature sensitivity in an RTV118-based two-color PSP was −1.4%/°C. Moreover, temperature sensitivity was independent of pressure in the tested temperature range. PtTFPP was used, and its pressure sensitivity was measured to be 0.5% per kPa. The two-color PSP paint underwent further examination in jet impingement experiments. The experimental results indicated that the pressure fluctuation introduced by the shock waves occurred earlier at higher impingement angles. Specifically, when the pressure ratio was 2.38, increasing the impinging angle from 15° to 30° caused the location of the pressure wave to move from s/D at 0.8 to the exit of the nozzle. Simultaneously, the shape of the maximum pressure zone changed from a fan shape to a round shape. Additionally, the jet region expanded when the pressure ratio was increased.
Impulsive Aggression Break, Based on Early Recognition Using Spatiotemporal Features
Authors: Donia Manar M. F. , El-Behaidy Wessam H. , Youssif Aliaa A. A.
Published: September 2023

The study of human behaviors aims to gain a deeper perception of stimuli that control decision making. To describe, explain, predict, and control behavior, human behavior can be classified as either non-aggressive or anomalous behavior. Anomalous behavior is any unusual activity; impulsive aggressive, or violent behaviors are the most harmful. The detection of such behaviors at the initial spark is critical for guiding public safety decisions and a key to its security. This paper proposes an automatic aggressive-event recognition method based on effective feature representation and analysis. The proposed approach depends on a spatiotemporal discriminative feature that combines histograms of oriented gradients and dense optical flow features. In addition, the principal component analysis (PCA) and linear discriminant analysis (LDA) techniques are used for complexity reduction. The performance of the proposed approach is analyzed on three datasets: Hockey-Fight (HF), Stony Brook University (SBU)-Kinect, and Movie-Fight (MF), with accuracy rates of 96.5%, 97.8%, and 99.6%, respectively. Also, this paper assesses and contrasts the feature engineering and learned features for impulsive aggressive event recognition. Experiments show promising results of the proposed method compared to the state of the art. The implementation of the proposed work is available here.
Q8VaxStance: Dataset Labeling System for Stance Detection towards Vaccines in Kuwaiti Dialect
Authors: Alostad Hana , Dawiek Shoug , Davulcu Hasan
Published: September 2023

The Kuwaiti dialect is a particular dialect of Arabic spoken in Kuwait; it differs significantly from standard Arabic and the dialects of neighboring countries in the same region. Few research papers with a focus on the Kuwaiti dialect have been published in the field of NLP. In this study, we created Kuwaiti dialect language resources using Q8VaxStance, a vaccine stance labeling system for a large dataset of tweets. This dataset fills this gap and provides a valuable resource for researchers studying vaccine hesitancy in Kuwait. Furthermore, it contributes to the Arabic natural language processing field by providing a dataset for developing and evaluating machine learning models for stance detection in the Kuwaiti dialect. The proposed vaccine stance labeling system combines the benefits of weak supervised learning and zero-shot learning; for this purpose, we implemented 52 experiments on 42,815 unlabeled tweets extracted between December 2020 and July 2022. The results of the experiments show that using keyword detection in conjunction with zero-shot model labeling functions is significantly better than using only keyword detection labeling functions or just zero-shot model labeling functions. Furthermore, for the total number of generated labels, the difference between using the Arabic language in both the labels and prompt or a mix of Arabic labels and an English prompt is statistically significant, indicating that it generates more labels than when using English in both the labels and prompt. The best accuracy achieved in our experiments in terms of the Macro-F1 values was found when using keyword and hashtag detection labeling functions in conjunction with zero-shot model labeling functions, specifically in experiments KHZSLF-EE4 and KHZSLF-EA1, with values of 0.83 and 0.83, respectively. Experiment KHZSLF-EE4 was able to label 42,270 tweets, while experiment KHZSLF-EA1 was able to label 42,764 tweets. Finally, the average value of annotation agreement between the generated labels and human labels ranges between 0.61 and 0.64, which is considered a good level of agreement.
Influence of Lateral Sitting Wedges on the Rasterstereographically Measured Scoliosis Angle in Patients Aged 10–18 Years with Adolescent Idiopathic Scoliosis
Authors: Feustel Andreas , Konradi Jürgen , Wolf Claudia , Huthwelker Janine , Westphal Ruben , Chow Daniel , Hülstrunk Christian , Drees Philipp , Betz Ulrich
Published: September 2023

Adolescent idiopathic scoliosis (AIS) is a three-dimensional axial deviation of the spine diagnosed in adolescence. Despite a long daily sitting duration, there are no studies on whether scoliosis can be positively influenced by sitting on a seat wedge. For the prospective study, 99 patients with AIS were measured with the DIERS formetric III 4D average, in a standing position, on a level seat and with three differently inclined seat wedges (3°, 6° and 9°). The rasterstereographic parameters ‘scoliosis angle’ and ‘lateral deviation RMS’ were analysed. The side (ipsilateral/contralateral) on which the optimal correcting wedge was located in relation to the lumbar/thoraco-lumbar convexity was investigated. It was found that the greatest possible correction of scoliosis occurred with a clustering in wedges with an elevation on the ipsilateral side of the convexity. This clustering was significantly different from a uniform distribution (p < 0.001; chi-square = 35.697 (scoliosis angle); chi-square = 54.727 (lateral deviation RMS)). It should be taken into account that the effect of lateral seat wedges differs for individual types of scoliosis and degrees of severity. The possibility of having a positive effect on scoliosis while sitting holds great potential, which is worth investigating in follow-up studies.
Guar-Based Injectable Hydrogel for Drug Delivery and In Vitro Bone Cell Growth
Authors: Poudel Humendra , RanguMagar Ambar B. , Singh Pooja , Oluremi Adeolu , Ali Nawab , Watanabe Fumiya , Batta-Mpouma Joseph , Kim Jin Woo , Ghosh Ahona , Ghosh Anindya
Published: September 2023

Injectable hydrogels offer numerous advantages in various areas, which include tissue engineering and drug delivery because of their unique properties such as tunability, excellent carrier properties, and biocompatibility. These hydrogels can be administered with minimal invasiveness. In this study, we synthesized an injectable hydrogel by rehydrating lyophilized mixtures of guar adamantane (Guar-ADI) and poly-β-cyclodextrin (p-βCD) in a solution of phosphate-buffered saline (PBS) maintained at pH 7.4. The hydrogel was formed via host-guest interaction between modified guar (Guar-ADI), obtained by reacting guar gum with 1-adamantyl isocyanate (ADI) and p-βCD. Comprehensive characterization of all synthesized materials, including the hydrogel, was performed using nuclear magnetic resonance (NMR) spectroscopy, Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), X-ray diffraction (XRD), thermogravimetric analysis (TGA), and rheology. The in vitro drug release study demonstrated the hydrogel’s efficacy in controlled drug delivery, exemplified by the release of bovine serum albumin (BSA) and anastrozole, both of which followed first-order kinetics. Furthermore, the hydrogel displayed excellent biocompatibility and served as an ideal scaffold for promoting the growth of mouse osteoblastic MC3T3 cells as evidenced by the in vitro biocompatibility study.
Unraveling the Immunopathogenesis of Multiple Sclerosis: The Dynamic Dance of Plasmablasts and Pathogenic T Cells
Authors: Matsuzaka Yasunari , Yashiro Ryu
Published: September 2023

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system, characterized by multiple lesions occurring temporally and spatially. Additionally, MS is a disease that predominates in the white population. In recent years, there has been a rapid increase in the number of patients, and it often occurs in young people, with an average age of onset of around 30 years old, but it can also occur in children and the elderly. It is more common in women than men, with a male-to-female ratio of approximately 1:3. As the immunopathogenesis of MS, a group of B cells called plasmablasts controls encephalomyelitis via IL-10 production. These IL-10-producing B cells, called regulatory B cells, suppress inflammatory responses in experimental mouse models of autoimmune diseases including MS. Since it has been clarified that these regulatory B cells are plasmablasts, it is expected that the artificial control of plasmablast differentiation will lead to the development of new treatments for MS. Among CD8-positive T cells in the peripheral blood, the proportion of PD-1-positive cells is decreased in MS patients compared with healthy controls. The dysfunction of inhibitory receptors expressed on T cells is known to be the core of MS immunopathology and may be the cause of chronic persistent inflammation. The PD-1+ CD8+ T cells may also serve as indicators that reflect the condition of each patient in other immunological neurological diseases such as MS. Th17 cells also regulate the development of various autoimmune diseases, including MS. Thus, the restoration of weakened immune regulatory functions may be a true disease-modifying treatment. So far, steroids and immunosuppressants have been the mainstream for autoimmune diseases, but the problem is that this kills not only pathogenic T cells, but also lymphocytes, which are necessary for the body. From this understanding of the immune regulation of MS, we can expect the development of therapeutic strategies that target only pathogenic immune cells.
MPPT of PEM Fuel Cell Using PI-PD Controller Based on Golden Jackal Optimization Algorithm
Authors: Agwa Ahmed M. , Alanazi Tarek I. , Kraiem Habib , Touti Ezzeddine , Alanazi Abdulaziz , Alanazi Dhari K.
Published: September 2023

Subversive environmental impacts and limited amounts of conventional forms of energy necessitate the utilization of renewable energies (REs). Unfortunately, REs such as solar and wind energies are intermittent, so they should be stored in other forms to be used during their absence. One of the finest storage techniques for REs is based on hydrogen generation via an electrolyzer during abundance, then electricity generation by fuel cell (FC) during their absence. With reference to the advantages of the proton exchange membrane fuel cell (PEM-FC), this is preferred over other kinds of FCs. The output power of the PEM-FC is not constant, since it depends on hydrogen pressure, cell temperature, and electric load. Therefore, a maximum power point tracking (MPPT) system should be utilized with PEM-FC. The techniques previously utilized have some disadvantages, such as slowness of response and largeness of each oscillation, overshoot and undershoot, so this article addresses an innovative MPPT for PEM-FC using a consecutive controller made up of proportional-integral (PI) and proportional-derivative (PD) controllers whose gains are tuned via the golden jackal optimization algorithm (GJOA). Simulation results when applying the GJOA-PI-PD controller for MPPT of PEM-FC reveal its advantages over other approaches according to quickness of response, smallness of oscillations, and tininess of overshoot and undershoot. The overshoot resulting using the GJOA-PI-PD controller for MPPT of PEM-FC is smaller than that of perturb and observe, GJOA-PID, and GJOA-FOPID controllers by 98.26%, 86.30%, and 89.07%, respectively. Additionally, the fitness function resulting when using the GJOA-PI-PD controller for MPPT of PEM-FC is smaller than that of the aforementioned approaches by 93.95%, 87.17%, and 87.97%, respectively.
A Navigation Path Search and Optimization Method for Mobile Robots Based on the Rat Brain’s Cognitive Mechanism
Authors: Liao Yishen , Yu Naigong , Yan Jinhan
Published: September 2023

Rats possess exceptional navigational abilities, allowing them to adaptively adjust their navigation paths based on the environmental structure. This remarkable ability is attributed to the interactions and regulatory mechanisms among various spatial cells within the rat’s brain. Based on these, this paper proposes a navigation path search and optimization method for mobile robots based on the rat brain’s cognitive mechanism. The aim is to enhance the navigation efficiency of mobile robots. The mechanism of this method is based on developing a navigation habit. Firstly, the robot explores the environment to search for the navigation goal. Then, with the assistance of boundary vector cells, the greedy strategy is used to guide the robot in generating a locally optimal path. Once the navigation path is generated, a dynamic self-organizing model based on the hippocampal CA1 place cells is constructed to further optimize the navigation path. To validate the effectiveness of the method, this paper designs several 2D simulation experiments and 3D robot simulation experiments, and compares the proposed method with various algorithms. The experimental results demonstrate that the proposed method not only surpasses other algorithms in terms of path planning efficiency but also yields the shortest navigation path. Moreover, the method exhibits good adaptability to dynamic navigation tasks.
A New Understanding of Long Non-Coding RNA in Hepatocellular Carcinoma—From m6A Modification to Blood Biomarkers
Authors: Eun Jung Woo , Cheong Jae Youn , Jeong Jee-Yeong , Kim Hyung Seok
Published: September 2023

With recent advancements in biological research, long non-coding RNAs (lncRNAs) with lengths exceeding 200 nucleotides have emerged as pivotal regulators of gene expression and cellular phenotypic modulation. Despite initial skepticism due to their low sequence conservation and expression levels, their significance in various biological processes has become increasingly apparent. We provided an overview of lncRNAs and discussed their defining features and modes of operation. We then explored their crucial function in the hepatocarcinogenesis process, elucidating their complex involvement in hepatocellular carcinoma (HCC). The influential role of lncRNAs within the HCC tumor microenvironment is emphasized, illustrating their potential as key modulators of disease dynamics. We also investigated the significant influence of N6-methyladenosine (m6A) modification on lncRNA function in HCC, enhancing our understanding of both their roles and their upstream regulators. Additionally, the potential of lncRNAs as promising biomarkers was discussed in liver cancer diagnosis, suggesting a novel avenue for future research and clinical application. Finally, our work underscored the dual potential of lncRNAs as both contributors to HCC pathogenesis and innovative tools for its diagnosis. Existing challenges and prospective trajectories in lncRNA research are also discussed, emphasizing their potential in advancing liver cancer research.
Effect of Low Testosterone Levels on the Expression of Proliferator-Activated Receptor Alpha in Female Patients with Primary Biliary Cholangitis
Authors: Kempińska-Podhorodecka Agnieszka , Abramczyk Joanna , Cielica Eliza , Huła Bartosz , Maciejowska Hanna , Banales Jesus , Milkiewicz Piotr , Milkiewicz Małgorzata
Published: September 2023

Sex-dependent patterns in chronic immune-mediated cholangiopathies, like primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), remain poorly understood. Peroxisome proliferator-activated receptor alpha (PPAR-α), expressed in immune cells, plays a key role in innate defence. In this study, the relationship between PPAR-α expression in peripheral blood mononuclear cells (PBMCs), serum androgen levels, IFNγ production, and sex-dependent tendencies during the development of PBC and PSC was investigated. We confirmed that normal cholangiocytes respond to PPAR-α and inhibit the lipopolysaccharide-induced expression of IL-6, IL-1b, and TNFα. Compared with PSC patients, PPAR-α was downregulated, while IFNγ was upregulated, in the PBMCs of PBC patients. When the analysis was conducted on females only, there was no difference in PPAR-α, but IFNγ was elevated in females with PBC compared with those with PSC. Serum testosterone concentrations in females with PBC were below the normal range (regardless of age) and correlated positively with PPAR-α and negatively with IFNγ. While PPAR-α has been reported to be a target of miR-155 and miR-21, no correlations with these microRNAs were observed in the PBMCs. However, a positive correlation between miR-21 and IFNγ was observed. Our results showed suppressed PPAR-α expression accompanied by reduced testosterone levels in women with PBC, which should elicit interest in the role of testosterone in PBC development.
Epidural Injection of Harpagoside for the Recovery of Rats with Lumbar Spinal Stenosis
Authors: Hong Jin Young , Kim Hyun , Yeo Changhwan , Lee Junseon , Jeon Wan-Jin , Lee Yoon Jae , Ha In-Hyuk
Published: September 2023

Epidural administration is the leading therapeutic option for the management of pain associated with lumbar spinal stenosis (LSS), which is characterized by compression of the nerve root due to narrowing of the spinal canal. Corticosteroids are effective in alleviating LSS-related pain but can lead to complications with long-term use. Recent studies have focused on identifying promising medications administered epidurally to affected spinal regions. In this study, we aimed to investigate the effectiveness of harpagoside (HAS) as an epidural medication in rats with LSS. HAS at various concentrations was effective for neuroprotection against ferrous sulfate damage and consequent promotion of axonal outgrowth in primary spinal cord neurons. When two concentrations of HAS (100 and 200 μg/kg) were administered to the rat LSS model via the epidural space once a day for 4 weeks, the inflammatory responses around the silicone block used for LSS were substantially reduced. Consistently, pain-related factors were significantly suppressed by the epidural administration of HAS. The motor functions of rats with LSS significantly improved. These findings suggest that targeted delivery of HAS directly to the affected area via epidural injection holds promise as a potential treatment option for the recovery of patients with LSS.
Bicarbonate-Activated Hydrogen Peroxide for an Azo Dye Degradation: Experimental Design
Authors: Mora-Bonilla Karla Y. , Macías-Quiroga Iván F. , Sanabria-González Nancy R. , Dávila-Arias María T.
Published: September 2023

The present study investigated the degradation of an aqueous Allura Red AC (AR–AC) solution by activating hydrogen peroxide with bicarbonate using cobalt ion (Co2+) as the catalyst. Four independent variables (H2O2, NaHCO3, Co2+, and dye concentrations) were analyzed in the composite central design (CCD). AR–AC degradation was optimized using the response surface methodology (RSM). Under optimal degradation conditions (41.86 mg/L AR–AC, 5.58 mM H2O2, 2.00 mM NaHCO3, and 9.00 µM Co2+), decolorization > 99.86%, mineralization (CO2 to conversion) of 12.99%, and total nitrogen removal of 51.97% were achieved. The predicted values for the three response variables were consistent with the experimental values, with determination coefficients (R2) greater than 0.9053. Because cobalt ions (Co2+) are a source of water pollution, after oxidation, these were adsorbed on sodium bentonite (Na–Bent), obtaining a final concentration of <0.01 mg/L. Bicarbonate-activated hydrogen peroxide is a potential technology for dye wastewater treatment that operates at an alkaline pH and at ambient temperature.
Temperature Modulation of MOS Sensors for Enhanced Detection of Volatile Organic Compounds
Authors: Rescalli Andrea , Marzorati Davide , Gelosa Simone , Cellesi Francesco , Cerveri Pietro
Published: September 2023

Disease diagnosis through biological fluids, particularly exhaled breath analysis, has gained increasing importance. Volatile organic compounds (VOCs) present in exhaled breath offer diagnostic potential as they reflect altered and disease-specific metabolic pathways. While gas chromatography–mass spectrometry (GC–MS) has been traditionally used for VOCs detection, electronic noses have emerged as a promising alternative for disease screening. Metal oxide semiconductor (MOS) sensors play an essential role in these devices due to their simplicity and cost-effectiveness. However, their limited specificity and sensitivity pose challenges for accurate diagnosis at lower VOCs concentrations, typical of exhaled breath. To address specificity and sensitivity issues, temperature modulation (TM) has been proposed in this paper, introducing a custom-developed electronic nose based on multiple and heterogeneous gas sensors located within an analysis chamber. Four different TM patterns (i.e., square, sine, triangular, and a combination of square and triangular) were applied to the gas sensors to test their response to three different analytes at three distinct concentrations. Data were analyzed by extracting meaningful features from the sensor raw data, and dimensionality reduction using principal component analysis (PCA) was performed. The results demonstrated distinct clusters for each experimental condition, indicating successful discrimination of analytes and concentrations. In addition, an analysis of which set of sensors and modulation pattern yielded the best results was performed. In particular, the most promising TM pattern proved to be the square and triangular combination, with optimal discrimination accuracy between both concentrations and analytes. One specific sensor, namely, TGS2600 from Figaro USA, Inc., provided the best performance. While preliminary results highlighted the potential of TM to improve the sensitivity of gas sensors in electronic nose devices, paving the way for further advancements in the field of exhaled breath analysis.
Parental Knowledge and Perceptions on Prevention of Sudden Unexpected Infant Death and Infant Care
Authors: Nazaruk Dziyana , Palacios Ana M. , Chopak-Foss Joanne , Mayo-Gamble Tilicia L. , Marshall Nandi A.
Published: September 2023

(1) Background: The study’s purpose was to explore the knowledge, perceptions, and confidence of mothers about infant care to reduce the risk of sudden unexpected infant death. (2) Methods: A purposeful sampling method was used to recruit 15 first-time mothers from Georgia with infants under 1 year of age. The researchers utilized the Socio-ecological model to report the results. Participants also provided recommendations on how to improve infant care and reduce the risk of SUID. (3) Results: The confidence level of infant care among most participants was low but increased over time. Mothers’ knowledge level about the prevention of SUID was high, but poor emotional health could hurt their parental abilities. Most participants recognized medical providers as the main source of reliable information. However, a lack of emotional and physical support was reported by mothers. (4) Conclusions: Results suggested that a more holistic approach to infant care is needed. The healthcare system and communities should provide more physical, social, and mental support to first-time mothers, a consolidated approach to care before and after birth, and easy access to services at all stages of the process to reduce the risk of SUID.
Evaluating the Use of PROMs in Paediatric Orthopaedic Registries
Authors: Morris Eleanor J. , Gray Kelly , Gibbons Paul J. , Grayson Jane , Sullivan Justin , Amorim Anita B. , Burns Joshua , McKay Marnee J.
Published: September 2023

Patient-reported outcome measures (PROMs) provide structured information on the patient’s health experience and facilitate shared clinical decision-making. Registries that collect PROMs generate essential information about the clinical course and efficacy of interventions. Whilst PROMs are increasingly being used in adult orthopaedic registries, their use in paediatric orthopaedic registries is not well known. The purpose of this systematic review was to identify the frequency and scope of registries that collect PROMs in paediatric orthopaedic patient groups. In July 2023, six databases were systematically searched to identify studies that collected PROMs using a registry amongst patients aged under 18 years with orthopaedic diagnoses. Of 3190 identified articles, 128 unique registries were identified. Three were exclusively paediatric, 27 were majority paediatric, and the remainder included a minority of paediatric patients. One hundred and twenty-eight registries collected 72 different PROMs, and 58% of these PROMs were not validated for a paediatric population. The largest group of orthopaedic registries collected PROMs on knee ligament injuries (21%). There are few reported dedicated orthopaedic registries collecting PROMs in paediatric populations. The majority of PROMs collected amongst paediatric populations by orthopaedic registries are not validated for patients under the age of 18 years. The use of non-validated PROMs by registries greatly impedes their utility and impact. Dedicated orthopaedic registries collecting paediatric-validated PROMs are needed to increase health knowledge, improve decision-making between patients and healthcare providers, and optimise orthopaedic management.
The Impact of COVID-19 on Multidisciplinary Care Delivery to Children with Cerebral Palsy and Other Neuromuscular Complex Chronic Conditions
Authors: Nguyen Hillary Brenda , Mulpuri Neha , Cook Danielle , Greenberg Michael , Shrader M. Wade , Sanborn Ryan , Mulpuri Kishore , Shore Benjamin J.
Published: September 2023

The COVID-19 pandemic has caused unprecedented challenges in the care of children with cerebral palsy (CP) and other neuromuscular complex chronic conditions (NCCCs). The purpose of this study is to explore the direct impact of the COVID-19 pandemic on healthcare delivery. From May to August 2020, medical professionals caring for CP and NCCC patients across multiple countries and disciplines completed a self-administered cross-sectional survey comparing practices before and during the COVID-19 pandemic. Of the 79 healthcare workers from eight countries who participated—predominantly pediatric orthopedic surgeons (32%), pediatricians (30%), and pediatric physiatrists (23%)—most of them felt that caring for NCCC patients during the pandemic presented unique difficulties, and they reported a significant decrease in the in-person NCCC clinic volume (p < 0.001), multidisciplinary appointments (p < 0.001), surgical cases (p = 0.008), and botulinum toxin/phenol injections. Most providers affirmed that institutional guidelines for perioperative emergent/urgent and elective procedures, workplace settings, and technology were modified to accommodate the ongoing public health crisis. The usage of telemedicine significantly increased for NCCC patient visits (p < 0.001). During the COVID-19 pandemic, many children with NCCCs lost access to routine, multidisciplinary care. Telemedicine became an integral part of communication and management. In the setting of the COVID-19 pandemic and with the threat of future healthcare disruptions, these data lay the foundation for trending the evolution of healthcare delivery and accelerating best practice guidelines for children with CP and NCCCs.
State of the Art Bowel Management for Pediatric Colorectal Problems: Spinal Anomalies
Authors: Bokova Elizaveta , Prasade Ninad , Rosen John M. , Lim Irene Isabel P. , Levitt Marc A. , Rentea Rebecca M.
Published: September 2023

Background: Patients with spinal abnormalities often struggle with fecal and/or urinary incontinence (up to 87 and 92%, respectively) and require a collaborative approach to bowel management in conjunction. Methods: To define existing approaches and propose state-of-the-art bowel management, a literature search was performed using Medline/PubMed, Google Scholar, Cochrane, and EMBASE databases and focusing on the manuscripts published July 2013 and July 2023. Results: Patients with spinal anomalies have impaired innervation of the rectum and anal canal, decreasing the success rate from laxatives and rectal enemas. Thus, transanal irrigations and antegrade flushes are widely utilized in this group of patients. Based on spinal MRI, the potential for bowel control in these children depends on age, type, and lesion level. On referral for bowel management, a contrast study is performed to assess colonic motility and evacuation of stool, followed by a series of abdominal X-rays to define colonic emptying and adjust the regimen. The options for management include laxatives, rectal enemas, transanal irrigations, antegrade flushes, and the creation of a stoma. Approximately 22–71% of patients achieve social continence dependent on the type and level of the lesion. Conclusion: Patients with spinal anomalies require a thorough assessment for continence potential and stool burden prior to initiation of bowel management. The optimal treatment option is defined according to the patient’s age, anatomy, and mobility. The likelihood of independent bowel regimen administration should be discussed with the patients and their caregivers.
Analysis of the Composite Risk Grade for Multi Extreme Climate Events in China in Recent 60 Years
Authors: Zhang Cunjie , Xiao Chan , Li Shuai , Ren Yuyu , Zhang Siqi , Cai Xiuhua , Sangbu Zhujie
Published: September 2023

Much attention has been given to the change rule of a single extreme event, and there are few reports on comprehensive characteristics of multiple extreme events in a certain region. Based on the analyzes of annual frequency of extreme high temperature, extreme low temperature, extreme drought, extreme precipitation, and extreme typhoon events in China from 1961 to 2020, a multi extreme events composite risk grade index (MXCI) was constructed and applied to the comprehensive characteristics analyzes of multiple extreme events in China. The results show that the high value areas of MXCI were mainly located in southeast China and southwest China. Over the past 60 years, the MXCI has shown a decreasing trend in western China and most of southeastern China, and an increasing trend in the middle zone from southwest China to northeast China. Through comparative analysis, MXCI can objectively reflect the comprehensive characteristics of multiple extreme climate events in a region, which is helpful to understand regional extreme climate characteristics and effectively cope with extreme climate risks.
Specifying the Gap between Nations’ Outward-Looking and Domestic Climate Policies: A Call for Measures of Domestic Climate Policy Stringency
Authors: Eisenstadt Todd A. , Lopez Jennifer
Published: September 2023

As nations fail to meet their climate emission mitigation goals, the ambition gap is widening between international climate policy (enacted by the United Nations) and domestic climate policy (what nations propose and enact). A widely held but little verified conventional wisdom exists that nations over-promise internationally and under-deliver domestically. While little data exist to directly test this hypothesis, we documented this gap by constructing heuristic indexes of domestic and international climate policy performance, showing that nations tend to “lead with the international”. We found that nations’ domestic policies are not significant in explaining emissions, although their international policies are significant. We concluded that beyond identifying this gap, analysts must devise metrics to assess domestic climate policy across a range of issue areas, as domestic policies are the foundation of any global effort to manage climate change.
Estimation of Temperature-Dependent Thermal Conductivity and Heat Capacity Given Boundary Data
Authors: Sharahy Abdulaziz , Sawlan Zaid
Published: September 2023

This work aims to estimate temperature-dependent thermal conductivity and heat capacity given measurements of temperature and heat flux at the boundaries. This estimation problem has many engineering and industrial applications, such as those for the building sector and chemical reactors. Two approaches are proposed to address this problem. The first method uses an integral approach and a polynomial approximation of the temperature profile. The second method uses a numerical solver for the nonlinear heat equation and an optimization algorithm. The performance of the two methods is compared using synthetic data generated with different boundary conditions and configurations. The results demonstrate that the integral approach works in limited scenarios, whereas the numerical approach is effective in estimating temperature-dependent thermal properties. The second method is also extended to account for noisy measurements and a comprehensive uncertainty quantification framework is developed.
Cheese and Milk Adulteration: Detection with Spectroscopic Techniques and HPLC: Advantages and Disadvantages
Authors: Vlasiou Manos C.
Published: September 2023

Cheese and milk are stapled dairy products consumed globally. However, adulterants in these products pose significant health risks and compromise their quality. Analytical techniques are crucial in detecting and quantifying adulterants to combat adulteration. This opinion explores the problem of cheese and milk adulteration, highlights the role of spectroscopic techniques (fluorescence spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, and infrared (IR) spectroscopy) in adulteration detection, and compares their effectiveness with the well-established high-performance liquid chromatography (HPLC) method. The advantages and limitations of each technique are discussed, providing valuable insights into their applications to ensure the authenticity and safety of cheese and milk products.
Event-Triggered Bounded Consensus Tracking for Second-Order Nonlinear Multi-Agent Systems with Uncertainties
Authors: Ma Ying , Gu Chan , Liu Yungang , Yu Linzhen , Tang Wei
Published: September 2023

This paper is concerned with event-triggered bounded consensus tracking for a class of second-order nonlinear multi-agent systems with uncertainties (MASs). Remarkably, the considered MASs allow multiple uncertainties, including unknown control coefficients, parameterized unknown nonlinearities, uncertain external disturbances, and the leader’s control input being unknown. In this context, a new estimate-based adaptive control protocol with a triggering mechanism is proposed. We rule out Zeno behavior by testifying that the lower bound on the interval between two consecutive events is positive. It is shown that under the designed protocol, all signals caused by the closed-loop systems are bounded globally uniformly and tracking errors ultimately converge to a bounded set. The effectiveness of the devised control protocol is demonstrated through a simulation example.
Evolution of Robustness in Growing Random Networks
Authors: Tyloo Melvyn
Published: September 2023

Networks are widely used to model the interaction between individual dynamic systems. In many instances, the total number of units and interaction coupling are not fixed in time, and instead constantly evolve. In networks, this means that the number of nodes and edges both change over time. Various properties of coupled dynamic systems, such as their robustness against noise, essentially depend on the structure of the interaction network. Therefore, it is of considerable interest to predict how these properties are affected when the network grows as well as their relationship to the growth mechanism. Here, we focus on the time evolution of a network’s Kirchhoff index. We derive closed-form expressions for its variation in various scenarios, including the addition of both edges and nodes. For the latter case, we investigate the evolution where single nodes with one or two edges connecting to existing nodes are added recursively to a network. In both cases, we derive the relations between the properties of the nodes to which the new node connects along with the global evolution of network robustness. In particular, we show how different scalings of the Kirchhoff index can be obtained as a function of the number of nodes. We illustrate and confirm this theory via numerical simulations of randomly growing networks.
A Comparative Study of Face-to-Face and Online Interprofessional Education Models for Nursing Students in Japan: A Cross-Sectional Survey
Authors: Saitoh Aya , Yokono Tomoe , Sumiyoshi Tomoko , Kawachi Izumi , Uchiyama Mieko
Published: September 2023

This study investigated the effects of an online interprofessional education (IPE) program on nursing students at a university in Japan. It conducted a comparative analysis between traditional face-to-face and online interventions. All students who enrolled in the “Team Medical Practice” course in both 2019 and 2020 were invited to participate. After team-based learning with different healthcare professions, we quantitatively analyzed pre- and post-intervention outcomes using two measures: the Readiness for Interprofessional Learning Scale (RIPLS) and the IPE Questionnaire TSUKUBA model (IPET). We compared the results of 153 nursing students. The RIPLS results demonstrate significant pre- and post-intervention score differences in the teamwork and collaboration subscale for the online group only. The post-IPE score analysis revealed that scores were significantly higher in the online group in all subscales: Teamwork and collaboration, Opportunities for IPE, and Uniqueness of profession. Based on the IPET results, there were no significant differences in pre- and post-intervention scores. However, the online group showed a significant increase in post-intervention scores in participation in group work, thoughts about the team in health and welfare, and thoughts about interprofessional collaboration. These findings indicate that the online IPE program improved nursing students’ readiness for interprofessional learning, demonstrating practical efficacy.