bluuebunny/crossref_metadata_2025 huggingface dataset:
The T350G Variation of Human Papillomavirus 16 E6 Gene Prevails in Oropharyngeal Cancer from a Small Cohort of Greek Patients
Authors: Kottaridi Christine , Resta Panagiota , Leventakou Danai , Gioti Katerina , Zygouras Ioannis , Gouloumi Alina-Roxani , Sakagiannis Georgios , Alzahrani Khalid J. , Venetikou Maria S. , Anthouli-Anagnostopoulou Fragkiski , Beloukas Apostolos
Published: August 2022

Recent trends have shown a dramatic rise in the incidence of oropharyngeal squamous cell carcinoma strongly associated with high-risk human papillomavirus (HPV) of type 16. The genetic variability of HPV16 has been extensively studied in cervical cancer but there are very limited published data concerning the genetic variations of this HPV type in oropharyngeal cancer. In the present study, the genetic variations of HPV16 E6 gene sequences originated from a small cohort of Greek patients diagnosed with oropharyngeal cancer were assessed. The vast majority of the sequences clustered within the European variant branch. The T350G variation was found to be the predominant one. This finding may indicate the need for further studies that could explain the possible impact of this variant in the pathomechanisms of oropharyngeal cancer.
Modelling the Economic Impact of lnfluenza Vaccine Programs with the Cell-Based Quadrivalent Influenza Vaccine and Adjuvanted Trivalent Influenza Vaccine in Canada
Authors: Nguyen Van Hung , Roy Bertrand
Published: August 2022

In Canada, approximately 12,000 people annually are hospitalized with influenza. While vaccination is the most effective method for reducing the burden of seasonal influenza, the propagation of vaccine virus strains in eggs can result in egg adaption, resulting in reduced antigenic similarity to circulating strains and thus lower vaccine effectiveness (VE). Cell-based propagation methods avoid these alterations and therefore may be more effective than egg-propagation vaccines. We evaluated three different scenarios: (1) egg-based quadrivalent influenza vaccine (QIVe) for individuals <65 years and adjuvanted trivalent influenza vaccine (aTIV) for ≥65 years; (2) QIVe (<65 years) and high-dose QIV (HD −; QIV; ≥65 years); and (3) cell-based derived QIV (QIVc; <65 years) and aTIV (≥65 years) compared with a baseline scenario of QIVe for all age groups. Modelling was performed using a dynamic age-structured SEIR model, which assessed each strain individually using data from the 2012–2019 seasons. Probabilistic sensitivity analysis assessed the robustness of the results with respect to variation in absolute VE, relative VE, number of egg-adapted seasons, and economic parameters. QIVe + aTIV was cost-saving compared with the baseline scenario (QIVe for all), and QIVe + HD − QIV was not cost-effective in the majority of simulations, reflecting the high acquisition cost of HD − QIV. Overall, while the incremental benefits may vary by influenza season, QIVc + aTIV resulted in the greatest reductions in cases, hospitalizations, and mortality, and was cost-effective (ICER < CAD 50,000) in all simulations.
In Silico Comparative Analysis of Predicted B Cell Epitopes against Dengue Virus (Serotypes 1–4) Isolated from the Philippines
Authors: Abesamis Lyn , Aliping Evan , Armada Fritz , Danao Mirriam , del Valle Pamela , Regencia Zypher , Baja Emmanuel , Ligsay Antonio
Published: August 2022

Dengue is a viral mosquito-borne disease that rapidly spreads in tropical and subtropical countries, including the Philippines. One of its most distinguishing characteristics is the ability of the Dengue Virus (DENV) to easily surpass the innate responses of the body, thus activating B cells of the adaptive immunity to produce virus-specific antibodies. Moreover, Dengvaxia® is the only licensed vaccine for DENV, but recent studies showed that seronegative individuals become prone to increased disease severity and hospitalization. Owing to this limitation of the dengue vaccine, this study determined and compared consensus and unique B cell epitopes among each DENV (1–4) Philippine isolate to identify potential areas of interest for future vaccine studies and therapeutic developments. An in silico-based epitope prediction of forty (40) DENV 1–4 strains, each serotype represented by ten (10) sequences from The National Center for Biotechnology Information (NCBI), was conducted using Kolaskar and Tongaonkar antigenicity, Emini surface accessibility, and Parker hydrophilicity prediction in Immune Epitope Database (IEDB). Results showed that five (5) epitopes were consensus for DENV-1 with no detected unique epitope, one (1) consensus epitope for DENV-2 with two (2) unique epitopes, one (1) consensus epitope for DENV-3 plus two (2) unique epitopes, and two (2) consensus epitopes and one (1) unique epitope for DENV-4. The findings of this study would contribute to determining potential vaccine and diagnostic marker candidates for further research studies and immunological applications against DENV (1–4) Philippine isolates.
Evaluation of Side Effects and Long-Term Protection of a Sustained-Release Injectable Moxidectin Formulation against Dirofilaria immitis Infection in Dogs: An Observational—In Field Multicentric Study
Authors: Vercelli Cristina , Bertolotti Luigi , Gelsi Elisa , Gazza Carlo , Re Giovanni
Published: August 2022

The sustained-release moxidectin formulation Afilaria SR is a relatively new product and has been labelled to prevent Dirofilaria immitis infection in dogs for a six months-period. An observational, in field multicentric study was performed, aiming to evaluate the tolerability and the long-term prevention of Afilaria SR in Italy, a country where filariasis is endemic. The study was designed to include not less than 300 dogs, older than 6 months, of any breed. Side effects were recorded by veterinarians and antigenic tests were performed after 210, 365, 730, and 1095 days after the administration of the drug. A total of 583 dogs were recruited from 2018 to 2021 and all of them were negative with respect to antigenic tests at all time points, indicating that 100% of protection was achieved. Ranking of adverse reactions and correlation to patient features were analyzed using descriptive statistics and χ2 square test, respectively. Afilaria SR was well tolerated: 13% of dogs experienced mild reactions and only two dogs out of 583 (0.3%) demonstrated anaphylactoid/angioneurotic reactions, resolved administering corticosteroids. These data support that Afilaria SR prevented Dirofilaria immitis disease in all enrolled dogs and the low number and the low grade of side effects indicate the high safety profile of the product.
Microbiome Profile of Dogs with Stage IV Multicentric Lymphoma: A Pilot Study
Authors: Mahiddine Feriel Yasmine , You Inhwan , Park Heekee , Kim Min Jung
Published: August 2022

Changes in the gut microbiome can be associated with diseases and affect the overall health of an individual. In the current study, the gut microbiome profile of dogs diagnosed with advanced stages of multicentric lymphoma was compared with that of healthy dogs and analyzed. For this purpose, dogs from veterinary hospitals diagnosed with lymphoma were selected and were further narrowed down to cases of stage IV multicentric lymphoma. Fecal samples from the selected sick and healthy dogs were collected and analyzed using MiSeq sequencing. The gut microbiota in the two groups of dogs was statistically analyzed and compared. The results revealed significant differences in the microbial populations present in sick and healthy dogs. Phylum Actinobacteria and two species (Corynebacterium amycolatum and Streptococcus lutetiensis) were found in high proportions in sick dogs and may be considered as potential biomarkers for canine stage IV multicentric lymphoma. Further investigations need to be conducted to understand the mechanisms they might be involved in.
Adsorption Mechanism of High-Concentration Ammonium by Chinese Natural Zeolite with Experimental Optimization and Theoretical Computation
Authors: Liu Pan , Zhang Aining , Liu Yongjun , Liu Zhe , Liu Xingshe , Yang Lu , Yang Zhuangzhuang
Published: August 2022

Natural zeolite, as an abundant aluminosilicate mineral with a hierarchically porous structure, has a strong affinity to ammonium in solutions. Adsorption mechanism of high-concentration ammonium (1000~4000 mg-N/L) in an aqueous solution without pH adjustment onto Chinese natural zeolite with the dosage of 5 g/L was revealed by the strategy of experimental optimization integrated with Molecular Dynamics (MD) simulation, and found the maximum ammonium adsorption capacity was 26.94 mg/g. The adsorption kinetics and isotherm analysis showed that this adsorption process fitted better with descriptions of the pseudo-second-order kinetics and Freundlich model. The theoretical calculations and infrared-spectrum characterization results verified the existence of hydrogen bonds and chemisorption. Therefore, the adsorption mechanism by natural zeolites of high-concentration NH4+ is defined as a process under the joint influence of multiple effects, which is mainly promoted by the synergy of the ion exchange process, electrostatic attraction, and chemisorption. Meanwhile, the hydrogen bond also plays an auxiliary role in this efficient adsorption. This study presents important theoretical significance for enriching the mechanism of zeolites adsorbing NH4+ from water, and provides reference and theoretical guidance for further exploring the potential application of natural zeolites.
Climate Change Implications for Metal and Metalloid Dynamics in Aquatic Ecosystems and its Context within the Decade of Ocean Sciences
Authors: Hauser-Davis Rachel Ann , Wosnick Natascha
Published: August 2022

Anthropogenic activities are affecting marine ecosystems, notably coastal ones, in multiple ways and at increasing rates, leading to habitat degradation, loss of biodiversity, and greater exposure of flora and fauna to chemical contaminants, with serious effects on ocean health. Chemical pollution, in particular, is a significant negative stressor for aquatic ecosystems, both oceanic and coastal, and has recently been identified as a priority for conservation efforts. Metals and metalloids, in particular, present environmental persistence, bioavailability, tendency to bioaccumulate along the trophic chain, and potential toxic effects. However, the current scenario of climate change is increasingly affecting the aquatic environment, altering water mass flows and the transport of pollutants, aggravating toxic effects and ecological risks. Moreover, although traditional sources of contamination have been studied for decades, many knowledge gaps persist, in addition to the emerging effects of climate change that are still poorly studied. In this regard, this review aims to discuss climate change implications for metal and metalloid dynamics in aquatic ecosystems and its context within the Decade of Ocean Sciences. We also discuss how an increasing interest in plastic pollution has led to contamination by metals and metalloids being neglected, requiring mutual efforts to move forward in the understating of the negative and often lethal impacts of this type of pollutants, thus aiming at prioritizing contamination by metals and metalloids not just in the oceans, but in all water bodies.
Revealing the Coral Species Diversity in Xiamen Bay: Spatial Distribution of Genus Astrogorgia (Cnidaria, Alcyonacea, Plexauridae) and Newly Recorded Species
Authors: Liu Jia-Ying , Wang Yun-Pei , Yang Jing , Shih Yi-Jia , Chu Ta-Jen
Published: August 2022

Coral reefs provide a habitat for many marine organisms and support the safety, coastal protection, well-being, and food and economic security of hundreds of millions of people. The focus on coral species diversity cannot be overemphasized. One of them, Astrogorgia, contains many marine natural active substances, and has important scientific research value and application prospects. Most of the current research on the active substances of the genus Astrogorgia is based on unidentified species, and in-depth taxonomic studies are urgently needed. A total of 1185 samples were collected from 2014 to 2021 in the waters of Xiamen Bay. Herein, the morphological identification, electronic microscopy, and gene fragment sequencing methods were used for the taxonomic study. There are three species of Astrogorgia identified, including Astrogorgia lafoa, A. arborea, and A. dumbea. Among them, A. lafoa and A. arborea are newly recorded species in the waters of China. A. lafoa is distributed in Qingyu Island, A. arborea is distributed in Wuyu Island, and A. dumbea is widely distributed in Baiha Reef, Qingyu Island, Wuyu Island, and Xiaobai Island. In this paper, the geographical distribution and the habits of 18 species of Astrogorgia are summarized, and the evolution of family and genus classification of Astrogorgia is discussed. The results enrich the geographical distribution information and coral species diversity records of Astrogorgia in China.
Groundwater Health Risk Assessment Based on Monte Carlo Model Sensitivity Analysis of Cr and As—A Case Study of Yinchuan City
Authors: Ma Zhiyuan , Li Junfeng , Zhang Man , You Di , Zhou Yahong , Gong Zhiqiang
Published: August 2022

Groundwater is an important resource for domestic use and irrigation in the Yinchuan region of northwest China. However, the quality of groundwater in this region is declining due to human activities, with adverse effects on human health. In order to study the effects of chemical elements in groundwater on human health, the human health risk of drinking groundwater was calculated based on the actual situation in China and on the U.S. Environmental Protection Agency (USEPA) model. Moreover, the sensitivity of contaminant exposure in drinking water wells was quantified using Monte Carlo simulation to minimize uncertainty in conjunction with USEPA risk assessment techniques, with the aim to identify the major carcinogenic factors. In addition, Visual Minteq was used to analyze the possible ionic forms of the major factors in the hydrogeological environment of the study area. The results showed that the mean CR values for As were 2.94 × 10−0.5 and 5.93 × 10−0.5 for the dry and rainy seasons, respectively, while for 2018 they were 5.48 × 10−0.5 and 3.59 × 10−0.5, respectively. In parallel, the CR values for children for 2017 were 6.28 × 10−0.5 and 1.27 × 10−0.4, respectively, and 1.17 × 10−0.4 and 7.67 × 10−0.5, respectively, indicating a considerably higher carcinogenic risk for children than for adults. results of the sensitivity analysis of Cr6+ and As using Crystal Ball software showed association values of 0.9958 and 1 for As and 0.0948 and 0 for Cr in the dry and rainy seasons in 2017, and 0.7424 and 0.5759 for As and 0.6237 and 0.8128 for Cr in the dry and rainy seasons in 2018, respectively. Only in the rainy season of 2018, the association values for As were lower than those for Cr, indicating that As is more sensitive to total carcinogenic risk. The results of the visual coinage model analysis showed that among all the possible ionic forms of As, the activity of HAsO42− had the largest logarithmic value and that of H3AsO4 had the smallest value, regardless of pH changes. This indicates that HAsO42− is the ionic form of As with the main carcinogenic factor in the hydrogeological environment of the study area. Therefore, corresponding environmental control measures need to be taken in time to strengthen the monitoring and control of As, especially HAsO42−, in the groundwater of the study area. This study is of great significance for Yinchuan city to formulate groundwater pollution risk management and recovery.
Works Created Within the Employment Relationship
Authors: Maneva Veselina
Published: August 2022

The research and analysis of the creative achievements created in the context of employment, have always asked a number of questions related to the nature of these works, with the rights that arise for the employer and author, with the manner of their enforcement and payment of fair remuneration. The institute of the official work is established both in the system of copyright and in industrial legislation. It is a means of regulating the relationship between employer and creator. Theory and practice increasingly determine the need for deeper and more comprehensive regulation of these relations and overcoming the existing gaps.
The Historical Role of the International Labour Organization for the Establishment of International Standards for Labour and Social Human Rights
Authors: Staykov Ivaylo
Published: August 2022

The subject of the research is the role of the International Labour Organization in establishing international standards for labour and social human rights. The analysis is dedicated to the 100th anniversary of the creation of this universal specialized international organization.
AKUNTANSI PENDAPATAN JASA BERBASIS NILAI MOHE;HEA DAN HUYULA
Authors:   IAIN Sultan Amai Gorontalo, Thalib Mohamad Anwar
Published: August 2022

This study aims to reveal how the Bendi coachman practices (earns) service income. The paradigm used is Islam with an Islamic ethnomethodology approach. There are five stages of data analysis; amal, ilmu, iman, informasi wahyu, and ihsan. The results showed that the bendi coachman earned service income from passenger fares by negotiating prices, delaying and freeing tariffs for passengers. This practice is driven by Islamic cultural values in the form of consensus (mohe; hea) and help (huyula). This value is based on the belief of the bendi charioteers that fortune has been arranged by God.
IMPLEMENTATION OF THE PRINCIPLES OF CRIMINAL PROCEDURE THROUGH THE MORAL PRINCIPLES OF THE POWERS OF THE INVESTIGATOR
Authors: Kibardin D.O.
Published: August 2022

In order to solve a crime and ensure a fair punishment of the guilty, the investigator is endowed with extensive powers, including the restriction of fundamental human and civil rights and freedoms, in connection with which the moral principles in the activities of this subject are of great importance. The figure of the investigator in this case should not only be procedurally independent, but also, in a sense, personify an impartial and fair pre-trial trial in the case. The latter directly depends on the availability and adherence to the moral principles of the powers of the investigator as a subject of criminal procedural relations. The effectiveness of the investigative bodies depends, among other things, on the implementation and observance of the principles of criminal procedure, since through their implementation the basic guarantees, human rights and freedoms are respected, and a fair trial is carried out. In the process of developing theoretical and practical provisions, setting goals and solving these tasks in order to obtain reliable and scientifically sound results, the author was guided by the general scientific dialectical method of cognition, as well as private scientific research methods: comparative legal, logical, system-structural, concrete sociological, statistical, etc. The article attempts to analyze the content of the concept of the principles of criminal procedure through the moral principles of the powers of investigators, as well as the analysis of certain gaps and problems existing in this area. The purpose of the study has been achieved, and the results of the article can be used in the practical activities of investigators, the development of methodological recommendations for investigative bodies, as well as for further study of this topic.
Weather Forecasting Analysis using Bayesian Regularization Algorithms
Authors: Intan Indo
Published: August 2022

Weather forecasting has become very urgent in various fields of human life, including in big cities. The need for weather forecasting accuracy will be effective and efficient in managing the quality of civilization flexibly. Bayesian regularization is one of the techniques used to obtain accurate results and development of artificial neural networks. The training process achieves the smallest epoch using a general processing unit to solve big data and high resolution. Scenarios performed via dataset partitioning and MSE enhancement. The addition of training data will improve system performance which indicates a significant increasing accuracy. Likewise, the decrease in MSE can increase the system accuracy to achieve a convergence stability point. Weather forecasting can recommend work units within the city and its surroundings, even between provinces or countries.
Field analyses of thickness shear bulk acoustic resonators with different electrode edge ratio using full three dimensional finite element method simulation
Authors: He Yiwen , Wong Yu-Po , Wu Ting , Bao Jingfu , Hashimoto Ken-ya
Published: August 2022

This paper is aimed at revealing origins of spurious resonances and Q deterioration of thickness shear bulk acoustic resonators (TSBARs) with the edge ratio W

x
/W

y
of rectangular electrodes by a field analyses. Here, W

x
and W

y
are distances between side edges giving the broadband and standard piston designs, respectively. The field distribution is calculated by applying traceback technique to the full three dimensional finite element method based on hierarchical cascading technique, its variation with the edge ratio is studied in detail, with assistance of the wavenumber domain analysis. The result indicates that the mode conversion and the leakage occur at the bump region causing Q reduction, and generated hybrid modes causing spurious resonances. The former is significant when W

x
/W

y
is large and the latter becomes obvious when W

x
/W

y
is small.
MITIGATION OF PARACETAMOL INDUCED GENOTOXICITY BY CURRY LEAVES ( MURRAYA KOENIGII) EXTRACT IN BONE BARROW CELLS OF SWISS ALBINO MICE MUS MUSCULUS
Authors: Verma Nidhi , Kumari Dharmshila
Published: August 2022

Paracetamol as common analgesics as well as antipyretic drug have become one of the favourite part of human lives several reports indicates its
toxicity on various organs including liver, kidney, heart with this due to production of its toxic metabolite, it causes production of tree radicals
which in turn damages the chromosome. In present study toxicity of chromosome was evaluated in mitotic metaphase chromosome of swiss albino
mice, isolated from bone marrow cells. Structural and mitotic disruptive changes were reported and its mitigation was done by antioxidant rich
curry leaves extracts. It was reported that frequency of Paracetamol treated group was signicantly higher (30.66%) than that of control 4.33%,
curry leaves treated group shows (3.33%) abnormalities whereas concurrent dose of both Paracetamol and curry leaves extract were 11.33%. The
curry leaves shows the ameliorating effect against Paracetamol induced genotoxicity.
MERGING ADVANCE TECHNOLOGY TO IMPROVE OUTCOMES IN HEART TRANSPLANTATION - A CASE REPORT
Authors: J Jang , S Pham , JM Ruiz , PC Patel , JC Leoni , DS Yip , JN Nativi , K Landolfo , B Sareyyupoglu , RM Goswami
Published: August 2022

One of the signicant obstacles to donor heart utilization is that increasingly prolonged cold ischemic times are associated with worsened short-
and long-term outcomes. As a result, most transplant centers aim to limit cold ischemic times to less than four hours. The TransMedics Organ Care
System (OCS) (Trans Medics, Andover MA) is a portable ex vivo perfusion system designed to store a donor heart in a beating, metabolically
active state, until it reaches the recipient, thereby allowing extended time outside the body while minimizing the effects of cold storage. We present
a case of a heart transplant recipient supported with the Impella 5.5 as a bridge to transplantation who received a donation after circulatory death
(DCD) heart supported by OCS. To our knowledge, this is the rst report of such a case.
A RARE SURGICAL COMPLICATION OF THE NONSTEROIDAL ANTI-INFLAMATORY DRUGS WITH ASSOCIATED PNEUMORETROPERITONEUM
Authors: Voicu Dragoș , Stan Dorina , Șerban Cristina , Constantin Bianca , Toma Alexandra , Popazu Constantin
Published: August 2022

Perforation of a duodenal ulceration, caused by chronic nonsteroidal anti-inammatory medication treatment, is a rare clinical event. Symptoms
are usually insidious and non-specic, so only clinical suspicion can lead to a proper diagnostic and optimal clinical management. We present a
case of perforated duodenal ulceration, with pneumoretroperitoneum, which presented to the hospital with diffuse abdominal pain, sub-fever and
altered general condition. CT scanning was essential in diagnosing the location, the extent and the nature of the lesion. No abnormalities were
evident at the initial inspection of the peritoneal cavity. After mobilization of the duodenum, a perforation was found on the medial wall of the
duodenum II, near the lower knee, through which the bile owed. Perforation suture, nasoduodenal tube and postoperative parenteral nutrition
were the key points of the surgical management.
Corrected Formulation of Precision of Topographic Measurements by Radar Interferometry
Authors: Weissman Isaac
Published: August 2022

This communication presents a corrected formulation, differing significantly from a traditional and widely- employed one, for the precision of topographic measurements by means of space-based or airborne radar interferometry. The reasons for this difference are suggested. The discrepancies are especially wide at near-nadir viewing. The corrected formulation is consistent with a simple physical model and is confirmed by numerical differencing using a spreadsheet analysis.
Wide Band Spectrum Monitoring System from 30MHz to 1800MHz with limited Size, Weight and Power Consumption by MRC-100 Satellite
Authors: Humad Yasir Ahmed Idris , Dudás Levente
Published: August 2022

Today, the usage of radio frequencies is steadily increasing based on the continuous development of modern telecommunication technologies, and this, in turn, increases the electromagnetic pollution not only on Earth but also in space. In low Earth orbit, electromagnetic pollution creates some kind of difficulty in controlling nano-satellites. So it is necessary to measure the electromagnetic pollution in the Low Earth Orbit. The basic aim of this paper is to present the capability of designing and developing a PocketQube-class satellite 3-PQ 5 x 5 x 15 cm as a potential continuation of SMOG-1, the fourth satellite of Hungary. The planned scientific payload of MRC- 100 is a wideband spectrum monitoring system for radio frequency smog in the frequency range of 30-2600 MHz on Low Earth Orbit (600 Km). In this paper, we have executed qualifying measurements on the whole system in the frequency range of 30-1800 MHz (first phase), and we calibrated its broadband antenna with a measurement system. We present the capabilities of the wideband spectrum monitoring system to measure radio frequency signals, with the limited size, weight, and power consumption of the designed system. The working spectrum measurement system was tested on the top of the roof of building V1 at BME University and An-echoic chamber, we were able to show that there is significant radio frequency smog caused by the upper HF band, FM band, VHF band, UHF band, LTE band, GSM band, 4G band, and UMTS band. This is relevant to the main mission target of MRC-100.
On the Quality of Experience of Content Sharing in Online Education and Online Meetings
Authors: Bat-Erdene Tushig , Zayed Yazan N. H. , Qiu Xinyu , Shakoor Ibrar , Mekni Achref , Kara Peter A. , Martini Maria G. , Bokor László , Simon Anikó
Published: August 2022

The turn of the decade introduced a new era of global pandemics to the world through the appearance of COVID-19, which is still an active crisis at the time of this paper. As a countermeasure, the phenomena of home office and online education became not only widely available, but also mandatory in many countries. However, the performance, reliability and general usability of such real-time activities may be severely affected by unfavorable network conditions. In both contexts, content sharing is now a common practice, and the success of the related use cases may fundamentally depend on it. In this paper, we present our surveys and subjective studies on the Quality of Experience of content sharing in online education and online meetings. A total of 6 surveys and 5 experiments are detailed, addressing topics of student experience, user interface settings, sharing options of lecturers and employees of the private sector, the perceivable effects of network impairments and the related long-term adaptation, the rubber band effect of slide sharing, the overall perceived quality and the separate quality aspects of media loading times, and the preference between visual quality, average frame rate and frame rate uniformity. The findings of the subjective studies do not characterize the use cases of the investigated topics on a general, widely-applicable level, as only a single online platform is involved throughout the experiments. However, their experimental configurations are reinforced by comprehensive surveys and many results indicate statistically significant differences between the selected test conditions.
OPTIMALISASI UMKM MADU LIAR DI DESA MANGUNAN, DLINGO, BANTUL DIY
Authors: Jusman Yessi , Tamara Renda Sukma , Sukmawati Nurul Kurnia , Nurulia Pinkan Adhisa , Kahfi Gigih Ashabul
Published: August 2022

Kegiatan Kuliah kerja nyata (KKN) Universitas Muhammadiyah Yogyakarta disaat pandemic ini menggunakan skema baru karena masih menghadapi situasi pandemi Covid-19. Pelaksanaan kuliah kerja nyata berbasis Informasi Teknologi (IT), kelompok 019 KKN IT UMY memilih Usaha Mikro Kecil dan Menengah (UMKM) Madu Asli Pak Sulaiman desa Mangunan sebagai mitra dalam pelaksaan program kerja yang disusun oleh kelompok 019 KKN IT UMY. Sasaran dari kegiatan pengabdian Kuliah Kerja Nyata di Desa Mangunan Kecamatan Dlingo, Kabupaten Bantul. Kegiatan ini berhubungan dengan mitra UMKM Madu Lebah Liar Desa Mangunan. Dengan target utama kegiatan KKN ini adalah untuk mengembangkan UMKM Madu Lebah Liar menjadi lebih berkembang dalam proses produksi, penyajian, dan pemasaran produk.
Genetic Characterization of Co-circulated Classic and Very Virulent Infectious Bursal Disease Viruses in Commercial Broiler Flocks of Egypt
Authors: Zanaty Ali , Mossad Zeinab , Said Mahmoud , Samy Mohamed , Rabie Neveen , Amer Fatma , Soliman Mohamed Ahmed
Published: August 2022

In recent years, the reintroduction of the infectious bursal disease virus (IBDV), particularly its severe strains, has imposed considerable cost on the Egyptian poultry industry. The goal of the current study was to investigate the molecular features of IBDV in Egypt from June 2019 to April 2021. A total of 30 field samples (bursa of Fabricius) were collected from broiler farms in which the chickens were vaccinated (Transmune 2512 s/c) at hatching. A highly variable region encompassing VP2 gene was targeted for IBDV screening utilizing reverse transcription-polymerase chain reaction (RT-PCR). Of 30 tested samples, 16 were positive by PCR. To isolate the virus, the bursal suspension was injected into 10-11 day embryonated chicken eggs via the chorioallantoic membrane. Five current positive isolates from 2021 were chosen for nucleotide and amino acid (aa) sequence analysis. Phylogenetically, three of the strains under study belonged to the very virulent (vvIBDV) strains, with 97-98% resemblance to Giza 2008 belonging to the (Genogroup 3) IBDV strain. The remaining two strains were identified as a vaccination strain (genotype 1) that matched the winter field 2512 vaccine strain by a similarity percentage of 98. Mutations in the antigenic locations of (P) domain loops were discovered when the sequencing samples were compared to the existing IBD vaccines. The circulating strains were found to be very similar to vvIBDV serotype 1 genotype 3 strains with mutations in the P domain loop providing a potential reason for the circulation of vvIBDV viruses in Egyptian broiler farms despite the vaccination program.
Nivel de complexidade assistencial de idosos internados: Perfil assistencial nas clínicas de um hospital universitário
Authors: de Oliveira Cantanhede Lucas Antônio , Oliveira Silva Andréa Cristina , Holanda Lopes Maria Lúcia , Costa Rabelo Poliana Pereira , De Abreu Lima Rafael , Moreira Ana Karoline
Published: August 2022

Objetivo: Conhecer o nível de complexidade assistencial de idosos internados. Métodos: Trata-se de um estudo retrospectivo, descritivo realizado em fichas de 161 idosos internados em um Hospital Universitário, entre janeiro a abril de 2018. Investigou-se dados sociodemográficos, clínicos, estilo de vida e sistema de classificação de pacientes proposto por Fugulin e colaboradores. A pesquisa consta aprovação do Comitê de Ética em Pesquisa do HUUFMA nº 2.306.474. Resultados: O perfil encontrado foi: sexo feminino (64,59%), com média de idade 70,1 (± 6,8), baixa escolaridade (59,01%) e baixa renda (72,67%), sedentário (67,70%), níveis pressóricos alterados (54,03%) e pré-sarcopênicos (39,13). Doenças cardiovasculares (31,0%) como causa de internação. O nível de complexidade assistencial era de cuidados mínimos (63,4%) e as áreas de cuidados mais afetadas foram sinais vitais, alimentação, cuidado corporal e terapêutica. Conclusão: Os idosos requeriam cuidados mínimos da enfermagem, mesmo com diagnóstico de doença cardíaca e condições sociodemográficas e clínicas desfavoráveis.
Technical Efficiency of Rice Farmers in Telangana, India: Data Envelopment Analysis (DEA)
Authors: Kumar K. Nirmal Ravi
Published: August 2022

It is known that the inability of the farmers to exploit the available production technologies results in lower efficiencies of production. So, the measurement of technical efficiency in agricultural crops in developing countries like India gained renewed attention in the late 1980s from an increasing number of researchers. Accordingly, the present study has employed Data Envelopment Analysis (DEA) and Malmquist Total Factor Productivity Index to ascertain the technical efficiency of rice productivity (2021-2022) and its changes over the study period (2019-2020 to 2021- 2022) respectively in Telangana, India. This study was based on secondary data pertaining to rice productivity (output variable), fertilizer doses (NPK), seed rate, water applied and organic manure (input variables). The findings of Data Envelopment Analysis revealed that the overall mean technical efficiency score across all the Decision-Making Units was 0.860 ranging between 0.592 and 1.000. So, the Decision-Making Units, on average, could reduce their input usage by 14 percent and still could produce the same level of rice output. Further, fertilizers (60.54 kg/ha); seed (5.63 kg/ha); water (234.48 mm) and organic manure (3.76 t/ha) use can be reduced without affecting the current level of rice productivity. Malmquist Total Factor Productivity indices (2019-2020 to 2021-2022) revealed that the mean scores of technical efficiency change, pure technical efficiency change and scale efficiency change are more than one (1.153, 1.042 and 1.009 respectively), unlike technological change (0.983). All the Decision-Making Units showed impressive progress with reference to technical efficiency change (1.112) and it is the sole contributor to Total Factor Productivity change in rice cultivation. The DEA results suggest that farmers should be informed about the use of inputs as per the scientific recommendations to boost the technical efficiency of rice productivity in Telangana. It also calls for policy initiatives for the distribution of quality inputs to the farmers to boost technical efficiency in rice production.
Data Collection in Street Begging Research in Nigeria: The State of the Art and Associated Challenges
Authors: Ojedokun Usman Adekunle
Published: August 2022

Nigeria is among the major countries contending with the social problem of street begging. The pervasiveness of the problem has continually placed it at the front burner of scholarly engagements and intellectual discourse. However, despite the existence of abundant literature on the phenomenon of street begging, the epistemological and methodological issues typically embedded in the process of data elicitation from street beggars in Nigeria are yet to command adequate scholarly attention. Therefore, this article attempted to fill this observed lacuna by focusing on the necessity for data collection on street begging and the major challenges that are associated with data elicitation from street beggars in Nigeria. The paper ascribed the necessity for data collection on street begging to multiple reasons. Language barrier, the fluid nature of street begging, the mobile nature of street beggars, and trust issue are among the major challenges that are associated with data collection on street begging research in Nigeria.
Modeling and Analysis of DC-DC CUK Converter with Coupled Inductors
Authors: Tuztasi Fatih M. , Yildiz Ali Bekir , Kelebek Hasan
Published: August 2022

In this article, the analysis of the inductive coupled CUK topology, which is a DC-DC converter, which is of great importance for power electronics and used in structures such as electric vehicles and PV systems, with Modified Nodal Analysis (MNA) and the modeling of the elements in the circuit structure will be explained. The numerical values of the semiconductors and passive circuit elements to be modeled will be given the voltage, and current at the output will be calculated. In addition, the graphs of the parameters analyzed and analyzed with MNA will be created with the code system written in the MATLAB environment and will be explained in this article.
The effect of weight bearing exercises on Spastic Diplegic Children
Authors: Aditi Singh  , Arpita Gupta  , Himandri Kapil
Published: August 2022

Introduction: Cerebral Palsy (CP) refers to the group of varied neurological conditions or disease or disease which alters the motor capacities, movements, tonicity of muscles & postural changes in a child. Spastic diplegic cerebral palsy impacts bilateral lower extremities causing troubles with gait stability & coordination. He or she performs awkward walking the reflex is heightened. A toddler with mild spastic diplegic may also stroll without an assistive tool for community travel on the other side intense spastic diplegic cp needs assistive tool to stroll household distance. Main concentration of this project is on Cerebral Palsy (spastic diplegia) children having increased muscle tone specially in lower limb as a major complain.
Methodology: 15 subjects were involved in the study aged from 1 to 10 years with a greater number of children falling GMFCS Level III and trained for weight bearing exercises, balance exercises, core exercises, positional exercises, walking exercises, modalities were also given to enhance the functioning of the muscle and worked to re-educate the muscles shows an increased result in the level of GMFCS from III to II. Modified Ashworth Scale was used to check the spasticity scoring present before and the rehabilitation program done for 6 weeks. Modified Time Up & Go Test was used to find out the functional capability and falling risks in children before and after the treatment.
Result: Data were collected based on spasticity level scored by using Modified Ashworth Scale (MAS) scoring (pre and post treatment for 6 weeks) and Modified Time Up & Go Test (MTUGT) scoring (pre and post treatment for 6 weeks) with respect to GMFCS levels improvements in each subject. Participants were having increased number of falls while walking for few meters ranges from 20-27s, [Mean (SD)= 23.06±1.34] as their baseline assessment; there was decreased number of falls and improved balance after the protocol followed ranges to 15-20s, [Mean (SD)= 16.87±1.50] after protocol followed for 6 weeks. Participants were having spasticity in their lower limbs which was scored by Modified Ashworth Scale reading 3 or 4, [Mean (SD)=3.33±0.49] as their baseline assessment; there was increase in muscle tone and some passive movements were difficulty while some show rigidity while performing flexion & extension. The scoring has been reduced to 1 or 2, [Mean (SD)= 2.33±0.50] after the rehab protocol.
Conclusion: The study will be able to able to identify the outcome measure of patient following weight bearing exercises Through this we conclude that when we provide the positional exercises, weight bearing exercises, and walking exercises in the treatment to the patients. It helps them to improve their spasticity level.Modalities were also used to initiate the muscles contraction and relaxation to re-educate the muscles to strengthen the muscles
FEATURES OF FUNCTIONING AND STATE REGULATION OF TOURISM IN THE CONTEXT OF A PANDEMIC
Authors: Агаева Лилия Кябировна , Уденцова Наталья Сергеевна
Published: August 2022

В статье рассматриваются особенности функционирования сферы туризма Российской Федерации в условиях пандемии. Выделены основные тенденции развития туризма. Представлены государственные меры поддержки сферы туризма в целях устранения негативного влияния пандемии.

The article discusses the peculiarities of the functioning of the tourism sector of the Russian Federation in the conditions of a pandemic. The main trends in the development of tourism are highlighted. The state measures to support the tourism sector in order to eliminate the negative impact of the pandemic are presented.
PROPOSALS FOR THE RESTORATION OF RECLAMATION SYSTEMS AND THE DEVELOPMENT OF LAND RECLAMATION IN THE STAVROPOL TERRITORY
Authors: Кирейчева Людмила Владимировна , Яшин Валерий Михайлович , Ялалова Гульшат Халиловна
Published: August 2022

Представлены материалы исследований функционирования орошаемого земледелия в Ставропольском крае. На основе данных официальной статистики рассмотрена динамика урожайности сельскохозяйственных культур за период с 2000 по 2021 годы, показана ее высокая вариативность несмотря на благоприятные природные условия. Средняя урожайность значительно ниже природного потенциала, что указывает на необходимость развития орошения и реализации агрохимических мероприятий. Даны предложения по совершенствованию инвестиционной и технологической политики в области мелиорации.

The materials of studies of the functioning of irrigated agriculture in the Stavropol Territory are presented. Based on official statistics, the dynamics of crop yields for the period from 2000 to 2021 is considered, its high variability is shown despite favorable natural conditions. The average yield is significantly below the natural potential, which indicates the need for the development of irrigation and the implementation of agrochemical measures. Proposals are given to improve the investment and technological policy in the field of land reclamation.
Non-iterativity, Icy Targets, and the Need for Non-linear Representations in Feature Spreading
Authors: McCollum Adam
Published: August 2022

Vowel and vowel-consonant harmonies have been central to much linguistic theorizing over the last century. One prevailing theme in this work is the need for non-linear representations. Clements (1981) and Jurgec (2011) argue for the superiority of non-linear representations for the analysis of unbounded and bounded feature spreading, respectively. This paper modifies and extends the metrical analysis in Jurgec (2011) to provide an Optimality Theoretic account for three bounded harmonies, rounding harmony in Central Crimean Tatar, as well as ATR harmony in Bangla and Iny. In all of these patterns, a vowel undergoes harmony but does not further propagate the harmonic feature. The metrical analysis is then compared to analyses employing string-based and autosegmental representations.
High Cardiorespiratory Fitness Protects against Molecular Impairments of Metabolism, Heart, and Brain with Higher Efficacy in Obesity-Induced Premature Aging
Authors: Pantiya Patcharapong , Thonusin Chanisa , Sumneang Natticha , Ongnok Benjamin , Chunchai Titikorn , Kerdphoo Sasiwan , Jaiwongkam Thidarat , Arunsak Busarin , Siri-Angkul Natthaphat , Sriwichaiin Sirawit , Chattipakorn Nipon , Chattipakorn Siriporn C.
Published: August 2022

Background: High cardiorespiratory fitness (CRF) protects against age-related diseases. However, the mechanisms mediating the protective effect of high intrinsic CRF against metabolic, cardiac, and brain impairments in non-obese versus obese conditions remain incompletely understood. We aimed to identify the mechanisms through which high intrinsic CRF protects against metabolic, cardiac, and brain impairments in non-obese versus obese untrained rats.Methods: Seven-week-old male Wistar rats were divided into two groups (n=8 per group) to receive either a normal diet or a highfat diet (HFD). At weeks 12 and 28, CRF, carbohydrate and fatty acid oxidation, cardiac function, and metabolic parameters were evaluated. At week 28, behavior tests were performed. At the end of week 28, rats were euthanized to collect heart and brain samples for molecular studies.Results: The obese rats exhibited higher values for aging-related parameters than the non-obese rats, indicating that they experienced obesity-induced premature aging. High baseline CRF levels were positively correlated with several favorable metabolic, cardiac, and brain parameters at follow-up. Specifically, the protective effects of high CRF against metabolic, cardiac, and brain impairments were mediated by the modulation of body weight and composition, the lipid profile, substrate oxidation, mitochondrial function, insulin signaling, autophagy, apoptosis, inflammation, oxidative stress, cardiac function, neurogenesis, blood-brain barrier, synaptic function, accumulation of Alzheimer’s disease-related proteins, and cognition. Interestingly, this effect was more obvious in HFD-fed rats.Conclusion: The protective effect of high CRF is mediated by the modulation of several mechanisms. These effects exhibit greater efficacy under conditions of obesity-induced premature aging.
A METHOD TO ESTIMATE TRAFFIC PENETRATION RATES OF COMMERCIAL FLOATING CAR DATA USING SPEED INFORMATION
Authors: Altintasi Oruc , Tuydes-Yaman Hediye , Tuncay Kagan
Published: August 2022

Floating Car Data (FCD) are being increasingly used as an alternative traffic data source due to its lower cost and high coverage area. FCD can be obtained by tracking vehicle trajectories individually or by processing multiple tracks anonymously to produce average speed information commercially. For commercial FCD, the spatio-temporal distribution of these vehicles in actual traffic, traffic Penetration Rate (PR) is the most important factor affecting the accuracy of speed estimations, despite the high number of registered vehicles feeding to an FCD provider, denoting the market PR. This study proposes a method for assessing the traffic PR of commercial FCD by evaluating its speed estimation quality compared to Ground Truth (GT) data. GT speed data were employed to generate different levels of traffic PR using Monte Carlo (MC) simulations, which resulted in the development of Quality-PR (Q-PR) relations for Mean Absolute Percentage Error (MAPE) and Root Mean Square Error (RMSE) as selected Measures of Effectiveness (MoE). Simulation-based FCD results at an urban road segment in Ankara (Turkey) showed that a quality of FCD with traffic PR of 15% or more would improve significantly. Use of the developed Q-PR relations suggested an approximately 5% traffic PR for the commercial FCD speeds at the location.