bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation of the Solidity Ratio in a Horizontal Wind Turbine
Authors: Tekşin Süleyman , Kurt Mert
Published: September 2021

A wind turbine-generator system; Parameters such as wind speed, turbine blade diameter, number of blades, turbine height, tip speed ratio and solidity ratio are affected. In this study, horizontal axis wind turbine with diameter of 130 cm and blade solidity ratio values of 7%, 8,6% and 9,8% were constructed and the tests were made according to different blade speed ratios. The required blades were obtained from PVC pipes of different diameters. The experimental study was actualized in Erciyes University Mechanical Engineering, Engines Laboratory. For each profile, blade rotational speeds and wind speeds at various distances have been studied. It has been determined that the wind speed is reduced by the distance difference and accordingly the number of blade speed is decreased visibly. In the wing profiles with different blade solidity ratios resulting from the work done, the wing structure with the solidity ratio of 8.6% gave the best performance. CL and CD coefficients of the profiled specimens were analyzed by FLUENTTM, a program of computational fluid dynamics. One of the factors that should be taken into consideration in the production of wind turbines is the blade solidity ratio.
Los primeros pasos del cristianismo alejandrino
Authors: Vives Cuesta Alfonso
Published: September 2021

En el presente estudio se pasa revista a las diferentes hipótesis que se han aducido para explicar el controvertido origen de la primera comunidad cristiana en Alejandría, realizando un análisis de un buen número de fuentes bíblicas y parabíblicas, canónicas y apócrifas, con el fin de describir la naturaleza real, tanto doctrinal como sociológica, de este “cristianismo marginado”. La metodología de análisis aplicada es doble, puesto que abarca tanto la crítica filológica, como el análisis histórico-sociológico.
La contribución de los Profetas al monoteísmo bíblico
Authors: Montes Peral Luis Ángel
Published: September 2021

En sus orígenes el monoteísmo no constituyó la esencia de la religión judía. El antiguo pueblo hebreo no fue monoteísta sino henoteísta: adoró al Dios vivo de Israel, pero pensó en la existencia de otros dioses, que protegían a los distintos pueblos y los acompañaban en sus avatares históricos. Los profetas, empezando por el gran Elias (s. IX a G), por Amos y Oseas (s. VIII a. C), y continuando por el Protoisaías, Jeremías y Ezequiel (siglos VIII-VI a. C), contribuyeron de manera decisiva a alcanzar la fe en el uno y único Yahvé. Pero fue el Deuteroisaías (s. VI a. G), el profeta de la incomparabilidad y trascendencia divinas, el mayor fenómeno teológico del Primer Testamento, el que puede ser considerado como el primer autor, propiamente monoteísta de la tradición bíblica, tanto en la exposición conceptual doctrinal como en la expresión lingüística.
Impact of Openness to Experience on Knowledge sharing under the mediating effect of Intention to share knowledge and moderating role of Interpersonal trust
Authors:   Capital University of Science and Technology, Islamabad, Pakistan, Anwar Kamran
Published: September 2021

The purpose of the study was to test the relationship between openness to experience and knowledge sharing under the mediating effect of intention to share knowledge and moderating effects of interpersonal trust. The data were collected from employees working in the public sector in Pakistan, with the sample size of 185. The results indicated that openness to experience significantly and positively predict knowledge sharing among employees, although the results showed that intention to share the knowledge does not mediate the relationship between the two. Similarly, as per findings, interpersonal trust failed to moderate the relationship between intention to share knowledge and knowledge sharing. Implications of the study are also discussed which provide a way forward to decision makers in the organizations in finding how to use knowledge sharing in the contextual settings of Pakistan.
Estado nutricional de pacientes críticos com úlcera por pressão em terapia enteral internados em UTI
Authors: Stephanie Alves Batista Thamires , Kadija Fonseca Santos Ramara , Santos da Rocha Barbara Rafaela , Freire Analícia Rocha Santos , Viana Pires Liliane
Published: September 2021

Objetivo: Avaliar a relação do estado nutricional com a evolução clínica de úlcera por pressão em pacientes em uso de Terapia Nutricional Enteral internados em Unidade de Terapia Intensiva. Métodos: Estudo observacional, transversal, realizado com pacientes com úlcera por pressão internados em hospital público do estado de Sergipe. O estado nutricional (antropometria, biomarcadores e ingestão dietética) foi avaliado na admissão do paciente na pesquisa (T0) e após uma semana de acompanhamento (T1). Resultados: Um total de 26 pacientes foi avaliado (58% do sexo masculino). A média de idade foi 54,6 anos. Doença neurológica correspondeu a 46% das causas de internação. Conforme o Índice de Massa Corporal, 47% dos adultos e 56% dos idosos apresentavam sobrepeso, enquanto 10% dos idosos e 33% dos adultos apresentaram desnutrição. A Circunferência da Panturrilha mostrou que 56% dos idosos apresentaram desnutrição no T0 e 33% no T1. Foi observada redução nos valores médios de albumina sérica no T1. A presença isolada da UPP na região sacral foi de 85%. Considerando o estágio prévio da UPP, no T1 observou-se que 54% dos pacientes mantiveram-se estáveis, enquanto 42% apresentaram piora e houve melhora do estágio IV para o III em apenas um paciente. A dieta ofertada era hiperproteica e sua composição não diferiu nos dois tempos. A avaliação da adequação da dieta mostrou que 61% dos pacientes não atingiram as necessidades energéticas no T0 e 58% no T1. Conclusão: Não foram observadas melhoras nos parâmetros bioquímicos e cicatrização dos pacientes com UPP internados em UTI em TNE.
O processo de implementação da integração lavoura-pecuária-floresta na percepção dos produtores rurais do estado de Mato Grosso
Authors: Domingues Ana , Camillo de Carvalho Marco Antonio , Cunha de França Raimundo Nonato
Published: September 2021

Os resultados de décadas de impactos da “moderna agricultura” apareceram, em maior ou menor grau, nas desigualdades sociais, exclusão, êxodo rural, concentração de terras e degradação ambiental. Para a mitigação de tal problemática, algumas estratégias vêm sendo pesquisadas, desenvolvidas e transferidas aos produtores rurais, dentre estas a Integração Lavoura-Pecuária-Floresta (iLPF) que adentrou na política nacional por meio do Plano Setorial para a Consolidação de uma Economia de Baixa Emissão de Carbono na Agricultura em 2009, conhecido como Plano ABC, e tornou-se uma política pública sob a Lei 12.805, sancionada em 2013. A partir da perspectiva de que as políticas públicas precisam ser compreendidas muito além de uma intervenção do Estado em situações consideradas problemáticas, mas como interação entre este e a sociedade, o estudo teve como objetivo analisar a percepção dos produtores rurais do estado de Mato Grosso sobre o processo de implementação da iLPF. Para isso, utilizou-se a pesquisa descritiva-exploratória com abordagem qualitativa. Na coleta dos dados foi aplicada a entrevista com o auxílio de um roteiro semiestruturado a 07 (sete) produtores rurais do estado de Mato Grosso que adotaram esse sistema de produção.
INTERROGATING CONCEPTIONS OF ‘MODERNITY’ AND ‘TRADITION’ IN THE PRODUCTION OF THE BUILT ENVIRONMENT IN SOUTH ASIA•
Authors: Viqar Sarwat
Published: September 2021

It has been argued that concepts of modernity and tradition are historical categories that emerged in the context of imperial encounters with the .other. during Colonization. This paper will show how the contingent nature of these categories becomes apparent when considering the production of the built environment in South Asia. The advent of British Colonialism in the 18th century precipitated a significant change in the urban landscape of South Asian cities. It also created a binary conception of a modern order that was a break from the local or native order of space. From then on, modernity became the institution of a liberal western order and tradition was what was retained by the natives that had been eclipsed by the new order. This trope of the dysfunctional Pre-Modern entered into native, nationalist imaginings of the past as well by establishing a binary between what was and what came after as being forever opposed to each other. In order to assert one, the other had to be negated. The Imperialist narrative achieved this through asserting the inherently moral nature and legitimacy of the Colonial order while the Nationalist narrative strove to recover the .tradition. that had been displaced by the Colonial order. The modern disciplines introduced with Colonial rule did provide a powerful prescriptive model of urban planning that created a privileged position for what has come to be seen as the modern form of the city. However, drawing upon contemporary South Asian urban historiography and research it is argued here that this order was constantly destabilized by native resistance, appropriation, hybridity and accommodation. In doing so, it appears that the production and reproduction of space in the built environment of South Asia constantly challenges notions of a dynamic, all-consuming modernity against a static tradition that needs to be preserved. Keywords: Modernity, tradition, colonial, culture
RECONCILING THE LIVING LANDSCAPE WITH OUR LIVING CULTURE
Authors: Goodey Brian
Published: September 2021

Conservation townscape ideas and understandings move with generations and innovations (Fallowwell et.al, 2010). As new generations respond to an electronic and globalised world, daily life and public policy seem to respond to events, often leaving the settings to take care of themselves. Often the only environmental response is to ensure basic facilities, or to enhance for the benefit of an essentially tourist market. The historic context of many decisions is having a hard time. One is not to compliment oneself on a job well done, nor does society often understand what one is doing. It is seen as a desirable commodity for those who can afford it, a significant factor in Western planning perhaps, but modest when faced with community protest for basic facilities. It is somewhat of a luxury, and it is treated as such. Culturally and politically one relies on the shared meanings and understandings behind current public life, and therefore on the landscape, both the green landscape and built settings provide a mental context for one's actions. So when London is mentioned a particular image of London comes to mind. That image might be a complex overlay of television images, personal visits, narrations from relatives, or political events. They all come together and everyone has a different image. The next decision about London, will be based on a combination of those images. The big question remains as to how, and to what degree, should these contexts be conserved, maintained and promoted in contemporary cultural life? The argument in this paper is around the fact that these past remnants are not just for the package holiday visitor, but their presentation serves as an essential, visible text to remind citizens of the origin of their current beliefs and aspirations. They are markers of where one has been. Urban squares, buildings, and routes, and the arrangement of rural land provide the textbook for what is to be retained, retrieved or rejected in the future, they are part of personal encyclopedias. They are often more eloquent and universal in their language than the modern polemic, and ways must be found for re-incorporating them into the thought process of a contemporary population. It is 'thinking differently' by the current generations, as well as the generations that are to follow, that is both interesting as well as very disturbing. Electronic media should be used to learn about place, but it also means that a lot of older ideas need to be re-evaluated with a big task at hand for teachers. The challenge for those who choose to conserve and understand such places is how to integrate them with the current ways of knowing. Keywords: Heritage, Urban Meanings, Culture, Landscape
IMPACT OF SYRIAN REFUGEES ON LEBANESE CITIES: A CASE STUDY OF SOLID WASTE MANAGEMENT
Authors: Ali Mansoor
Published: September 2021

Lebanon is one of the higher density countries in the world with a total population of four and a half million over an area of 10,000 square-kilometers. Its cities host around one and a half million displaced persons from Syria (including one million officially registered refugees), which is thirty percent of Lebanese population. The Government of Lebanon does not allow permanent refugee camps and the shelter provision is restricted to Informal Tented Settlements (ITS), but only twenty percent of the refugees are living in ITS1. The majority are integrated within the host population cities in rented housing, un-finished buildings and closed communities within communities. This has an impact on many basic services including solid waste management. This paper focuses on the solid waste services in Lebanese cities after Syrian crisis. The displaced Syrian population generates waste, which adds to the municipal stream and adds to already burdened collection system, which is politically complex. Hence, any improvements in solid waste management for refugees has to negotiate through the existing challenges. There is a lack of clarity in the responsibility to provide basic services to refugees and their rights to work, stay, travel etc. While there are international and national organisations supporting refugees, there are many limitations on what can or cannot be done with the refugees' population. For example, an organization can provide the communal bins near ITS, but municipality may or may not agree to transport those for further disposal, as the Syrian refugees do not pay taxes directly to municipalities. This paper is based on author's field work and case study methodology in this context and focuses on the background and complexity of solid waste service in Lebanese cities. The paper explains various institutional tensions in the given context and what can be done to overcome this. The paper concludes that in a situation like Lebanon, refugees supporting interventions must be prepared with a full understanding of the urban complexities, as there are 'cities beyond cities' to address. Keywords: Syria, Solid waste management, Refugees, Lebanon
EFFECTS OF WORK PLACE DESIGN ON BEHAVIORS
Authors: Salam Madiha
Published: September 2021

Nowadays people spend most of their time inside an enveloped building, their thoughts molded by the walls. In the eagerness of running with time the capitalist minds have forced humans to live like a machine which has resulted in much distress and mental tension as a part and parcel. So today, an average office worker has less productivity at the workplace and he/she comes home carrying the burden of work, which can hypothetically be improved by designing better spaces. Good architecture can heal a person and develop positive attributes in him/her. To be an architect with moral values, one must have deep appreciation of a human lifestyle and its capacity to adapt from its surroundings. This paper focuses on workplace environment and spaces in Karachi, considering the question how different spaces influence cognition? And is there an ideal architectural space for various kinds of thinking? The paper considers antiquity of the architectural determinism as a theory, and works upon the attributes which can diverge and positively enhance architectural perseverance through the review of archival data, articles, books and historical reference with support of questionnaires. The conclusion points towards the need of architecture to be developed into not just an envelope, but as a space which shapes the behavior, attribute and positivity of its users. Keywords: Architecture and behaviours, Cognitive architecture, work place environment.
PENERAPAN METODE BERMAIN PERAN UNTUK MENINGKATKAN KEMAMPUAN BERBICARA PADA MATA PELAJARAN BAHASA ARAB SISWA KELAS IX E MTSN 1 SERANG
Authors: Amin Ellyza
Published: September 2021

Speaking is one of four language-learning aspects. Based on experience, this aspect is difficult to develop because students are afraid to speak. However, the researchers tried to solve the problem by applying different learning methods. The method chosen is role play. The researcher conducted action research by applying the role-play method to 32 IX E MTsN 1 Serang City students. The action research used the Kemmis-McTaggart model in two cycles. In the action research, the variables measured were the increase in students' speaking skills and opinions on applying the role-play method. The analysis results showed that the students' speaking ability increased from cycle I to cycle II, namely the average class result in the first cycle was 71.88%. In the second cycle, the class average was 88.28%, meaning an increase of 16.40%. Thus, the researcher concludes that the role-play method can help students improve speaking skills in Arabic subjects. In addition, students generally stated that they were happy with the use of the role-play method.
Fortalecimiento del derecho de las mujeres indígenas y rurales en la gobernanza de tierras comunitarias
Authors:   Rights and Resources Initiative
Published: September 2021

Este informe identifica los factores que han contribuido al éxito de las iniciativas locales, nacionales y regionales empleadas en los países de ingresos bajos y medios para fortalecer los derechos de gobernanza de las mujeres indígenas y rurales en relación con las tierras comunitarias.
At a Crossroads: Consequential Trends in Recognition of Community-Based Forest Tenure from 2002-2017
Authors:   Rights and Resources Initiative
Published: September 2021

This analysis reports on trends in global forest tenure from 2002-2017. It is the fourth in a series of analyses monitoring the legal recognition of forest tenure around the world.
Effect Of Placement And Work Environment On Work Discipline And Their Impact On Performance Of Employee Office Jati Karya Village, Binjai City
Authors: Putra Suria Alamsyah
Published: September 2021

The purpose of this study was to analyze the direct effect of placement on the work discipline of the employees of the Jati Karya Sub-District Office, Binjai City. The research design in this research method includes explanatory research, which explains the causal relationship between the variables in the study. In conclusion, placement has a positive and insignificant effect on work discipline. These results indicate that better placement will not necessarily increase work discipline at the Jati Karya Sub-District Office, Binjai City. Work discipline in this study is influenced by placement through orientation / introduction, suitability of interests with work, suitability of abilities with work, suitability of knowledge with work, and knowledge possessed in accordance with work can improve work discipline in terms of complying with company regulations, working effectively, accept corrections, be present always on time and try to complete the work on time.
The Effect of Information Technology Utilization and Information System User Participation on System Performance Payroll
Authors: Dalimunthe Mohd.Idris
Published: September 2021

Every company has a payroll system that is designed in such away. Payroll system design is in line with system users. If the payroll system design is correct but the users are still difficult to run the system, it will complicate the decision-making process in the payroll.This study aims to determine the effect of the use of information technology and the participation of users of information systems on the performance. Types of associative research. The population of this research is all employees involved in the payroll process. Sampling using purposive sampling method of 35 respondents. Data processing using SPSS software. The results show that the use of information technology has a positive and significant effect on the performance of the payroll system. Information system user participation has a positive and significant effect on the performance of the payroll system. The use of information technology and the participation of information system users have a positive and significant effect on the performance of the payroll system.
ANALISIS STRATEGI PEMASARAN PRODUK SMARTPHONEVIVO DI TELEMARCO PADA INTERNATIONAL PLAZA PALEMBANG
Authors: Hendrayani Iin
Published: September 2021

Research of marketing strategy of Vivo smartphone products has been done at Telemarco at the Palembang International Plaza (IP). The purpose of this study was to find out the marketing strategy of the Smartphone Vivo product at the Palembang International Plaza. This research is a type of descriptive research using the method of presenting qualitative data which is analyzed using the SWOT method by describing the object of research based on strengths, weaknesses, opportunities and threats. Data collection techniques are carried out by means of Library Research and Field Research through observation and interviews. The results obtained from this study are that there are three  marketing strategies of Vivo Smartphone in Telemarco Company which have been implemented include product strategies that build brand image, pricing strategies include cash and credit purchases, promotional strategies in the form of advertisements in Television, Newspapers and Online media as well as promo brochures and gift giving. The marketing strategy that has been carried out by the Telemarco Company is basically in accordance with the results of the SWOT analysis conducted on Vivo Smartphone products which include elements of marketing mix strategies such as Produck, Price, Promotion, and Place. Suggestions that can be given by the author in this study, Vivo provides gifts to consumers and the ease of buying by installments or also giving discount prices to attract consumers to buy. Marketing strategy analysis needs to be done every year so that the company always gets a new alternative strategy that is more innovative so that the goal to reach market marketing leaders can be achieved.
PENGARUH KUALITAS AUDIT, LIKUIDITAS, SOLVABILITAS DAN PROFITABILITAS TERHADAP OPINI AUDIT GOING CONCERN PADA PERUSAHAAN PERDAGANGAN DI BURSA EFEK INDONESIA
Authors: Anggraini Yuni , Mulatsih Endang Sri , Rosalin Feronika
Published: September 2021

Companies that want to survive and advance need to develop new strategies. In an economy like this, nothing is always safe from competition, both local and global. Likewise, companies in the trading, service and investment industry sectors listed on the Indonesia Stock Exchange. The formulation of the problem in this research is the development of the influence of audit quality, liquidity, solvency and profitability on going concern audit opinion on trading companies on the Indonesia Stock Exchange for the period 2016-2018 seen partially and simultaneously. The purpose of this study was to see the development of the influence of audit quality, liquidity, solvency, profitability partially and simultaneously. The period used in this research is 2016-2018. The population in this study are trading companies listed on the IDX. The sample selection used purposive sampling method. Data analysis used to test the hypothesis is to use logistic regression analysis techniques. Based on the results of the study, it shows that research shows that partially, audit quality, liquidity, and solvency do not have a significant effect on going concern audit opinion. Meanwhile, simultaneously, there is at least one variable that has a significant influence on going-concern audit opinion.
Are There Gender Differences in Sustainable Entrepreneurship Indicators Amongst SMEs in South Africa? Application of MANOVA
Authors: Kanayo Ogujiuba , Olamide Ebenezer , Agholor Isaac , Boshoff Estelle
Published: September 2021

In addition to the contributions and relevance of entrepreneurship activities to economic growth and development of countries, various factors have equally been advanced as responsible for the success stories of entrepreneurship sustainability worldwide. However, the influence of success factors on gender ownership of entrepreneurship activities is a relatively new aspect in the field of research that has not gained much academic attention in the literature especially in South Africa. This debate is so important in the face of the various agitations for equal participation of women and the inconclusive debate that women are better managers of business enterprises. In this article, using the Multivariate Analysis of Variance (MANOVA) technique, we examined the extent to which sustainable entrepreneurship indicators (finance, social and environmental) account for any disparity in gender ownership and management of business enterprises in South Africa. A stratified sampling method was adopted for the survey. Our analytical technique (MANOVA) created a new summary dependent variable, which is a linear combination of each of our original dependent variables. Confidence intervals of 95% and margins of error (3%) were used to validate the results. Findings indicate that the only difference that exists as per gender ownership disparity is around financial resources. There is therefore a need to realign programmes and policies to reduce this gendered inequality.
Investigating the Relationship Between Country Competitiveness and Financial Market Development in Times of Crisis
Authors: Galanos George , Poufinas Thomas , Agiropoulos Charalampos
Published: September 2021

A country’s competitiveness depends on many factors related to general governance, effectiveness of markets, social development, and business perspectives. The role of financial markets for economic growth has been the subject of many scientific studies; most of them concluded that a well-developed financial system should improve the efficiency of financing decisions, favouring a better allocation of resources and thereby economic growth. The financial crisis that started in the summer of 2007 is still testing the strength of the global economic system. It started in the financial sector, but is now having an important impact on the real economy. The aim of this paper is to investigate the relationship between a country’s financial market development and its competitiveness in particular in times of crisis, with the use of a series of econometric models. We find evidence that financial market development is affected (with the anticipated sign of impact) by the Global Competitiveness Index, the GDP per capita and the (un)employment level of a country. It is also related (with an unexpected direction of impact) with the foreign market size and exports, as well as infrastructure. Our findings can be used by the policymakers of countries which wish to improve their competitiveness so as to steer the determining variables in the desired directions and approach their desired competitiveness levels.
Künstliche Intelligenz im politischen Diskurs
Authors: Willems Christina
Published: September 2021

As a key technology of the digital transformation, artificial intelligence has become part of our everyday lives. The AI-related effects on life and work have enormous social relevance and must therefore be addressed at the political level. This research work focusses on the discourse around AI useage in the German Bundestag – as the central location of debate in the democratic system – from the first mention of the term in 1984 to the establishment of the Enquete Commission in 2018, leading up to a critical discourse analysis. The year 2016 emerged as a turning point in the parliamentary discourse, which negotiates the political handling of the enormous potentials and risks of this technology.
Comparative Assessment of Topical Glucantime® Injection Plus Cryotherapy and Cryotherapy Alone for Treatment of Anthroponotic Cutaneous Leishmaniasis
Authors: Shirzadi Mohammad Reza , Hamta Amir , Zanjirani Farahani Leyli , Saghafipour Abedin , Rahi Sadegh
Published: September 2021

Background: Cutaneous leishmaniasis is a worldwide health problem due to the complications in the transmission cycle, treatment failure, and post-healing problems. Objectives: Infected humans are the parasite reservoirs in the transmission cycle of anthroponotic cutaneous leishmaniasis (ACL); thus, the lack of efficient treatment increases the risk of the disease outbreak. The gold standard treatment for CL is mainly the topical or systematic use of antimonial compounds. Much research has been done on the development of topical therapy alone or in combination with cryotherapy. Therefore, this study was conducted to comparatively evaluate the current treatment protocol, cryotherapy, versus combined cryotherapy (Cryo) and intralesional Glucantime® (IG). Methods: This quasi-experimental study was performed on 476 patients with cutaneous leishmaniasis lesions referred to the health centers of a CL endemic area in southern Iran (Bam County, Kerman Province) during 2013 - 2019. A total of 200 cases with 301 lesions received Cryo using liquid nitrogen once every two weeks, and 276 cases with 406 lesions received weekly IG combined with Cryo, once every two weeks. The lesion size was recorded before and after the treatment. At seven and 12 weeks after the treatment, the lesion healing rate was monitored. Healing was defined as complete re-epithelialization. The obtained data were assessed using logistic regression to calculate the relative risk and therapeutic effects. Results: Out of 476 CL patients with 709 lesions, 200 cases with 221 lesions received Cryo, and 276 patients with 292 lesions received Cryo plus IG. At the seventh week after the treatment, complete healing was observed in 100 out of 221 cases (50%) in the group that received biweekly Cryo only and 225 out of 276 cases (81.5%) in the group that received biweekly Cryo plus weekly IG (P = 0.001). Conclusions: This study found that the use of cryotherapy plus intralesional Glucantime® increases the chance of healing for patients by 4.4 times compared to the use of cryotherapy alone.
Synergistic Anti-proliferative Effects of Lenalidomide and Dexamethasone on the HT-29 Cell Line Through Apoptotic Genes
Authors: Hajimirza Shafiesoltani Pantea , Forouzesh Flora , Shabani Mahdi , Aghaei Mahmoud
Published: September 2021

Background: Colorectal cancer (CRC) is the third most common cancer among men and the second most common type of cancer among women worldwide. The resistance of tumor cells to apoptosis is caused by changes in the expression of anti-apoptotic or pro-apoptotic proteins. Histone deacetylase inhibitors (HDACi) are known to cause changes in gene expression. Objectives: The present study aimed at investigating the anti-proliferative effects of lenalidomide (LEN) as HDACi and dexamethasone (DEX) on the human colon cancer HT-29 cell line. Methods: The HT-29 cell line was treated with various concentrations of LEN and DEX individually and in combination for 24, 48, and 72 hours. Cytotoxicity was evaluated by MTT assay. The half-maximal inhibitory concentration (IC50) was measured, and quantitative real-time polymerase chain reaction (qRT-PCR) was also performed to examine the expression of Bcl2, Bax, Fas, and FasL genes. Results: The combination of LEN (1000 µM) with DEX (100 µM) showed potent synergistic anti-proliferative activities in a time- and dose-dependent manner. The combination of these drugs induced cell death by affecting the extrinsic and intrinsic apoptotic gene expression profiles. Conclusions: The combination of LEN with DEX can be proposed as a new therapeutic approach for CRC.
Illumina Accelerator: Next-Gen Corporate Accelerator with a Customer-Creation Focus
Authors: Joseph Diana , Cashin Amanda
Published: September 2021

We describe the history, design and expansion of Illumina for Startups -- a case that represents a company with strong entrepreneurial capacity engaging in open innovation through a startup accelerator now expanding internationally with different models. This case highlights the strategy and tactical reasoning behind Illumina’s approach.
Other Solid Cancers: 2021 ASCO Annual Meeting Highlights for the Advanced Practitioner
Authors: Fuoto, DNP, ANP-BC, AOCNP Abby , Lee, MSN, ANP-BC Mee-young
Published: September 2021

Abby Fuoto, DNP, ANP-BC, AOCNP®, ACHPN, of University of Arizona Cancer Center, considers the implications of a novel monoclonal antibody for nasopharyngeal cancer, and Mee-young Lee, MSN, ANP-BC, of Monter Cancer Center, Northwell, discusses the design of a basket trial for tumors with HER2 amplification or overexpression. Meeting coverage is provided by The ASCO Post.
Dışkaynak Tamir, Kayıp Satış ve Rassal Makine Kullanılmama Süresi Varsayımları Altında İki Aşamalı Tedarik Zinciri Modeli
Authors: ÖZTÜRK Harun
Published: September 2021

Günümüz küresel rekabet ortamında üreticiler ile endüstriyel alıcılar arasındaki işbirliğinin artması ve müşteri taleplerinin sürekli değişkenlik göstermesi tedarik zinciri stok yönetimi kavramının önemini giderek artırmaktadır. Bu çalışmada, tek bir üretici ve tek bir alıcıdan oluşan iki aşamalı tedarik zinciri modeli geliştirilmektedir. Tek cins ürün için verilen sipariş miktarı, herbir üretim çevrim süresi içinde eşit parti hacimli sevkiyatlar ile alıcıya teslim edilmektedir. Üretim sırasında kusurlu ürünlerin üretilmesi, kusurlu ürünlerin tamir edilebilir özellikte olması, tamir işleminin dışkaynak kullanılarak yapılması, makine arızalanması, bakım ve yeterli hammadde bulundurmama durumlarından dolayı üretimin gecikmesi temel varsayımlardandır. Alıcı için kusurlu ürünlerin tamir maliyeti ve kayıp satışlar maliyeti ortaya çıkmaktadır. Makine kullanılmama süresi rassal bir değişkendir ve sürekli tekdüze ve üstel dağılıma uymaktadır. Üretici ve alıcı için toplam maliyet fonksiyonları elde edilmiş ve daha sonra bütünleşik toplam maliyet fonksiyonu türetilmiştir. Bütünleşik toplam maliyet fonksiyonunu minimum yapan optimum sipariş miktarı ve sevkiyat sayısı, önerilen bir algoritma ile belirlenmiştir. Sayısal örnek ile modelin geçerliliği gösterilmiştir ve bazı model parametrelerinin optimal çözüm üzerindeki etkisi duyarlılık analizi ile incelenmiştir.
Spherical Fuzzy Version of EDAS and An Application
Authors: GÜL Sait
Published: September 2021

Several fuzzy set concepts have been developed after the first invention of fuzzy sets in 1960s with the aim of demonstrating the uncertainty and vagueness in human preferences. Spherical fuzzy sets (SFS) as a recent one of these developments support this aim by giving a comprehensive preference domain to decision makers. The distinctive feature of SFS is its rule saying that the squared sum of membership, non-membership, and hesitancy degrees should be within the interval of [0,1] while its each element is independently assigned within the same interval. With this study, EDAS (Evaluation Based on Distance from Average Solution), one of the younger but stronger multiple attribute decision making tools is modified for spherical fuzzy environment. Entropy-based objective attribute weighting is also integrated with this novel version of EDAS to avoid the undesired potential effects of subjective weighting such as longer data collection time. The novel version proposed is applied in an example of a product design selection problem for additive manufacturing.
Seçilmiş Bir Termik Santralde ESF Uygulamaları ve Verim Artırıcı Yöntemlerin İncelenmesi
Authors: KURT Baran , ÖZDEMİR Hüseyin , ORUÇ Halil , DEMİR Göksel
Published: September 2021

Günümüzde hava kirliliği, insanlığın en büyük sağlık tehdidi haline gelmiştir. Endüstri kaynaklı ve özellikle fosil yakıtla çalışan enerji santralleri atmosfere önemli miktarda emisyon salınımı yapmaktadır. Birey başına düşen enerji tüketim miktarının artması da ortaya çıkan hava kirliliğinin artmasına sebep olmaktadır. Yakıt olarak kömür kullanan enerji santrallerinin atmosfere yaydığı kirlilikte en büyük paya sahip kirleticilerden biri partikül kirleticilerdir. Termik santrallerde proses sırasında oluşan partikül kirleticiler, emisyon kontrol teknolojilerinden biri olan elektrostatik filtreler (ESF) vasıtasıyla atmosfere yayılımı en aza indirilmektedir. Bu çalışmada, ESF verimliliğini arttırmak için operasyon parametrelerinde değişiklikler yapılarak filtrelerin partikül tutma verimleri incelenmiştir. Farklı kül değerlerine ve elementel analiz sonuçlarına sahip 3 kömür çeşidinin ESF verimliliğine etkisi gözlemlenmiştir. ESF performansını etkileyebilecek uçucu gaz sıcaklığı değerleri kullanılarak senaryolar oluşturulmuş ve bunların etkisine bakılmıştır. Uçucu gaz konsantrasyonuna direkt olarak etki eden farklı hava ön ısıtıcı kaçak oranları için toz emisyon değerleri hesaplanmıştır. Bununla birlikte, ESF sistemi içerisindeki süreçlerde oluşabilecek problemleri gözlemlemek ve elektrik tasarrufu sağlamak amacı ile elektriksel alanların bazı bölümleri devre dışı bırakılmıştır. Bu çalışmanın sonucunda, farklı senaryolarda ortaya çıkan partikül emisyon değerleri analiz edilmiş ve senaryolardaki değişkenlerin ESF verimine etkisi değerlendirilmiştir.
Sınıf Öğretmenlerinin İş Sağlığı ve Güvenliği Öz Yeterliği (Iğdır İli Örneği)
Authors: TAŞDEMİR Celal , GÜR Bahri
Published: September 2021

Bu çalışmanın amacı; Iğdır ilinde görev yapan sınıf öğretmenlerinin İş Sağlığı ve Güvenliği öz yeterlik algılarını tespit etmektir. Bu araştırmanın seçilmesinde, 2020 yılına kadar Iğdır ilinde görev yapan sınıf öğretmenlerinin İş sağlığı ve Güvenliği öz yeterlik algılarına yönelik akademik bir çalışmaya rastlanmaması önemli bir etken olmuştur. Ölçek geliştirme çalışmaları araştırılarak araştırma için anket formu oluşturulmuştur. Uzman görüşü, yazım ve imla kontrollerinden sonra geliştirilen taslak anket ilk önce 110 sınıf öğretmenine uygulanmış daha sonra faktör analizine geçilmiştir. Güvenirlik hesaplama aşaması da tamamlandıktan sonra anketin son hali ortaya çıkmıştır. Araştırmanın evrenini Iğdır ilinde görev yapan 708 sınıf öğretmeni oluşturmaktadır. Araştırma kapsamında örneklemeye gidilmemiş, gönüllülük esasına göre araştırmacı tarafından bütün evrene ulaşılmaya çalışılmıştır. Araştırmaya gönüllü olarak katılan 366 sınıf öğretmeni araştırmanın nihai örneklemini oluşturmaktadır. Araştırmanın bağımsız değişkenleri; sınıf öğretmenlerinin İş Sağlığı ve Güvenliği bilgi düzeyleri, hizmet süreleri, çalışma durumları ve daha önce almış oldukları İSG eğitimi oluşturmaktadır. Araştırmanın bağımlı değişkeni ise; sınıf öğretmenlerinin İş sağlığı ve Güvenliği öz yeterlik algısına ilişkin ifadeleri oluşturmaktadır. Araştırmadan elde edilen veriler istatistiksel olarak analiz edilerek yorumlanmıştır. Bunun için SPSS (Sosyal Bilimler İçin İstatistik Paketi) programı kullanılmıştır. Verilerin çözümlenmesinde frekans, aritmetik ortalama, standart sapma, yüzde gibi betimsel istatistiklerden yararlanılmıştır. Fark analizlerinde iki bağımsız değişken için bağımsız örneklem t-Testi, bağımsız değişkenin ikiden fazla düzeyi olduğunda Varyans analizi kullanıldı. Araştırma sonucunda; Sınıf Öğretmenlerinin İş Sağlığı ve Güvenliği bilgi düzeyinin yüksek olduğu, öz yeterlik algılarının hizmet süresine ve çalışma durumuna göre anlamlı farklılık gösterdiği ve daha önce iş sağlığı ve güvenliği eğitimi almaları durumuna göre anlamlı bir fark olmadığı sonucuna varılmıştır.
The role of international bodies and organizations in the development of legal framework for application of video conferencing in criminal proceedings of the Russian Federation
Authors: Iurkevich Mariia Aleksandrovna
Published: September 2021

Legal regulation of the use of video technologies in the Russian criminal procedure is conducted on the international and domestic levels. However, based on the primacy of international law recognized by the Russian Federation, the marker is the position of international community that is reflected in the normative legal acts of its special bodies, as well as on the doctrinal level. This article carries out the chronological analysis of the acts issued by international bodies and organizations pertaining to the use video conferencing in criminal proceedings. The subject of this research is the acts of international bodies and organizations that underlie the development of the national legal framework for the use of video conferencing in the Russian Federation. The analysis of normative acts that regulate the use of video conferencing in the Russian criminal procedure demonstrate that for the most part this question is being addressed in the international agreements ratified by the Russian Federation, rather than in the national legislation (considering the provisions of the Part 3 of the Article 1 of the Criminal Procedure Code of the Russian Federation). Leaning on the acquired results, the author concludes that such tendency can be explained by a number of circumstances, namely lag in the rates of digitalization compared to the leading European practices, insignificant period of approbation of the results of using video technologies, as well as relatively short period of intensive implementation of such technologies due to the amendments in criminal procedure policy of the country, which now requires exhaustive normative regulation. The author believes that it is more appropriate to begin the analysis of normative acts that determine the legal framework for application of video conferencing in criminal proceedings of the Russian Federation with the general principles and norms of international law and international agreements, since their role in intensification of the process of digital transformation of criminal procedure in Russia cannot be overestimated.
New approaches towards creating journalistic content in the US media
Authors: Nerents Daria Valer'evna
Published: September 2021

Media convergence and digital revolution have become the reason of the important transformation processes that affected the editorial offices of all mass media. Constant information flow, public access to foreign media resources contributed to an unprecedented struggle for the audience. At the same time, the development of new technologies and software prompts the journalists to draw attention to the new opportunities and prospects that open up due to this. The subject of this research is the modern approaches towards interaction between the journalists and journalist with their audience, as well as use of technological capabilities within the framework of creating journalistic materials in the US mass media. The scientific novelty lies in the attempt to explore and systematize the new approaches towards creating media content that have emerged in the United States in the first half of the XXI century due to information and communication technologies and globalization of the information space, and commence to appear in Russia. Such research would allow to not only reveal the peculiarities of implementation of new techniques and methodologies in the US journalism, but also to see the development trends of the Russian journalism, since the experience of foreign colleagues has been used for decades. In conclusion, the author highlights the shift in priorities of the journalists, who prefer cooperation in creating large-scale resonance projects, rather than competition. Moreover, livening up the audience allows the journalists to involve it to creation of media content, and artificial intelligence may significantly reduce the time and financial costs to produce journalistic stories.
Interaction of interregional O3 pollution using complex network analysis
Authors: Zhang Qiang , Zhu Yunan , Xu Dianxiang , Yuan Jiaqiong , Wang Zhihe , Li Yong , Liu Xueyan
Published: September 2021

In order to improve the accuracy of air pollution management and promote the efficiency of coordinated inter-regional prevention and control, this study analyzes the interaction of O3 in Qilihe District, Lanzhou City, China. Data used for analysis was obtained from 63 air quality monitoring stations between November 2017 and October 2018. This paper uses complex network theory to describe the network structure characteristics of O3 pollution spatial correlation. On this basis, the node importance method is used to mine the sub-network with the highest spatial correlation in the O3 network, and use transfer entropy theory to analyse the interaction of pollutants between regions. The results show that the O3 area of Qilihe District, Lanzhou City can be divided into three parts: the urban street community type areas in urban areas, the township and village type areas in mountain areas and the scattered areas represented by isolated nodes. An analysis of the mutual influence of O3 between each area revealed that the impact of O3 on each monitoring station in adjacent areas will vary considerably. Therefore these areas cannot be governed as a whole, and the traditional extensive management measures based on administrative divisions cannot be used to replace all other regional governance measures. There is the need to develop a joint prevention and control mechanism tailored to local conditions in order to improve the accuracy and efficiency of O3 governance.
La canción reflexiva: en torno al estatuto crítico de la música popular en Brasil
Authors:   Universidade Estadual de Campinas, de Oliveira Gerolamo Ismael
Published: September 2021

En el siglo XX, la música popular fue el lenguaje artístico más contundente y una de las grandes fuerzas estéticas de Brasil. Desde los años 30, ella ocupó una posición importante en debates culturales y proyectos nacionalistas y, a lo largo de los años, expandió su alcance con el avance de los medios de comunicación. Dicha inversión todavía resultó, más allá de lo esperado, en la producción de una modalidad crítica de canción. Así que en los 60, Al igual que el arte moderno, la canción se tornó reflexiva, operando de manera crítica en relación a sí misma y al contexto cultural y político. El componente reflexivo de la canción parece haber ampliado considerablemente su alcance cultural. Tanto es así que no parece irrazonable señalar una conexión profunda entre la canción y un cierto horizonte de construcción nacional. En este trabajo, intentamos hacer un panorama del desarrollo de la música popular brasileña de modo a aclarar ese proceso y, tal vez, posibilitar nuevos planteamientos para pensar sus posibilidades críticas desde su dimensión estética.
Relaciones fronterizas y enredos visuales en el oasis de Quillagua (700-1500 d.C., norte de Chile)
Authors:   Centro Interdisciplinario de Estudios Interculturales e Indígenas, Programa Antropología, Pontificia Universidad Católica de Chile., Gallardo Francisco , Aguero Carolina ,   Instituto de Arqueología y Antropología, Universidad Católica del Norte., Cabello Gloria ,   Instituto de Estética, Centro Interdisciplinario de Estudios Interculturales e Indígenas, Pontificia Universidad Católica de Chile, Uribe Rodríguez Mauricio
Published: September 2021

Quillagua es un pequeño oasis junto al río Loa. La etnohistoria registra la convivencia de poblaciones indígenas de distinta tradición cultural. Picas tenían derechos territoriales hacia abajo de un poste de madera pintado y cepillado, mientras Atacamas hacia arriba. Estas categorías no eran geográficas sino indicaciones de una organización social dual. Aquí, indagamos en las expresiones materiales y visuales de esta tensa ocupación intercultural. Ponemos atención al registro arqueológico posterior al 900 d. C., época en que los actores desarrollaron numerosos ejercicios político-sociales, mediante la construcción de un paisaje visual.
Susan Sontag, ante la representación de la tortura
Authors:   Universidad Autónoma de Madrid, Albarrán Diego Juan
Published: September 2021

En varios de sus trabajos, Susan Sontag trató de pensar qué podían las imágenes de y ante el sufrimiento de los otros: ¿nos ayudan a comprender o nos insensibilizaban?, ¿en qué contextos y regímenes de circulación son capaces de generar solidaridad hacia la víctima?, ¿en qué condiciones fueron producidas y recepcionadas las fotografías de torturas inflingidas a prisioneros en Vietnam —en los años setenta— e Irak —en los dos mil— y hasta qué punto esas condiciones modifican la percepción social de las violaciones de los derechos humanos? El presente artículo trata de localizar, analizar y poner en valor las aportaciones de Sontag sobre las fotografías de atrocidades, en general, y de tortura en particular.