bluuebunny/crossref_metadata_2025 huggingface dataset:
Regional Competitiveness as an Aspect Promoting Sustainability of Latvia
Authors: Judrupa Ilze
Published: February 2021

Providing of sustainability is one of the main priorities in normative documents in various countries. Factors affecting regional competitiveness is seen as close to them determining sustainability in many researches. The aim of this research was to identify and evaluate main factors of competitiveness for statistical regions of Latvia to promote sustainable development of the country, applying the complex regional competitiveness assessment system developed by the author. The analysis of the Regional Competitiveness Index (RCI) and its sub-indexes showed that each statistical region has both: factors promoting and hindering competitiveness. Overall the most competitive is Riga statistical region, but the last place takes Latgale statistical region. It is possible to promote equal regional development and sustainability of Latvia by implementing well-developed regional development strategy and National Action Plan. To develop such strategies, it is necessary to understand the concept of sustainable competitiveness. To evaluate sustainable competitiveness of Latvia and its regions it is necessary to develop further the methodology of regional competitiveness evaluation.
Development of a Calculation Basis for the Goals and Objectives of Innovation Management at Industrial Enterprises in the Context of Post-Conflict Transformation
Authors: Klius Yuliia , Ivchenko Yevhen , Rozmyslov Alexander , Fatalov Vilen
Published: February 2021

Innovation management objectives completion phases at the industrial enterprise were developed. At the first phase a hierarchy of the corporate goals is formed. It is based on the expert and creative decision-making methods for the areas of the company's activity (production area, managerial - human resource management, financial, marketing, information-technological) and management levels (strategic, tactical, operational). The expert assessments in the second phase identify the initial goals of the innovation management system. In the third phase the relationship between goals and existing innovations in the corporation are defined. At this stage, a system of innovation management goals is formed. The proposed structure and method for forming an innovation corporate base consisting of two modules (the individual and group innovation bases), the basis of which consists of a set of job assignments and corresponding to each job assignment a combination of individual and group innovations or knowledge about them. Each task corresponds to a specific goal of managing innovation. The economic impact of introducing an integrative approach to innovation management in industrial enterprises is calculated.
ASSESSMENT OF THE CONSISTENCY OF INTERACTION BETWEEN SPECIALISTS IN THE FRAMEWORK OF PSYCHOSOCIAL REHABILITATION
Authors: Mitikhin Vyacheslav , Solokhina Tatyana
Published: February 2021

Objectives. System analysis of the problem of evaluating the effectiveness of interaction between specialists of polyprofessional teams during psychosocial rehabilitation interventions

Methods. Psychometric, sociological, system analysis methods and algorithms of the Analytical Hierarchy Process (AHP) [1, 2].

Results. The multiprofessional team consists of specialists with different skills, qualifications and positions in the management hierarchy. As a result, issues of leadership, subordination, and consensus lead to a loss of performance, both for individual members of these teams and for the teams themselves as a whole.

As the main example [2], we consider the hierarchy corresponding to the problem of establishing a functional diagnosis of a patient within a
multiprofessional team.

It is established that the original complex hierarchy can always be divided into a set of simple hierarchies that model the main stages of the work of a multiprofessional team.

The formation of procedures and algorithms for processing the results of expert information to assess the weight and consistency of decisions made by specialists is based on the AHP.

Conclusions. Obtained on the basis of AHP numerical evaluation [1, 2], unlike the rank method can be used for any mathematical processing and the development of appropriate regression models assess the effectiveness of psychosocial treatment of employees, treatment methods, patient characteristics and environment. References. 1. 1. Mitikhin V.G, Solokhina T.A. Neurology Bulletin. 2020(1):30-33. doi.org/10.17816/nb16459; 2. Mitikhin V.G., Solokhina T.A. S.S. Korsakov Journal of Neurology and Psychiatry, 2019, 119(2): 49-54. doi:10.17116/jnevro201911902149
AÇÃO DOCENTE E O DIÁLOGO INADIÁVEL SOBRE A DIVERSIDADE NA OBRA “A CONVERSA SOBRE GÊNERO NA ESCOLA”, DE MARCOS RIBEIRO
Authors: Ramos Edimauro
Published: February 2021

Sob um olhar interdisciplinar, a obra "A conversa sobre gênero na escola: aspectos conceituais e políticos-pedagógicos", do autor e pedagogo Marcos Ribeiro, delineia perspectivas do trabalho docente em torno deste tema, os seus desafios e suas possibilidades. O presente artigo pretende, por intermédio da revisão bibliográfica, promover interlocuções teóricas e dialogar sobre as potencialidades propostas no livro de Ribeiro no que se refere a inserir esses debates e mediá-los entre o trabalho docente e gênero, bem como refletir sobre a maneira de conduzir esses debates. Constata-se através do estudo que, por meio da introdução do tópico gênero nos mais diferentes contextos da escola, os professores/as e os educandos são condicionados a reivindicar por um espaço mais democrático e que abranja e respeite as diversidades.PALAVRAS-CHAVE: Gênero. Trabalho docente. Escola.
MACHISMO E ESTEREÓTIPOS DE GÊNERO: ANÁLISES DE UMA INTERVENÇÃO NA DISCIPLINA DE BIOLOGIA NO ENSINO MÉDIO
Authors: Favero Ana Carolina , Link da Silva Larissa Izabelli , De Carvalho Joana Tatiele , Emmel Rúbia , Krul Alexandre José
Published: February 2021

Esta investigação teve o objetivo de compreender concepções de machismo e estereótipos de  gênero dos estudantes e identificar como relacionam essas temáticas. Realizado por meio de uma pesquisa bibliográfica e de campo, houve um questionário fechado reflexivo e um jogo didático intitulado “Tribunal de Opinião”, baseado em Rojão et al (2011). A intervenção revela o valor destas temáticas no ensino das Ciências/Biologia, pois foi possível analisar duas categorias definidas a priori, que propiciaram diálogos e identificações, biologicamente e socialmente. Portanto, evidencia-se a importância destas temáticas no contexto educacional assim como social, na identificação dos estudantes com os temas e na ampliação de conhecimentos relacionados ao ensino de Biologia havendo maior presença de diálogo e reflexões.
FORMAÇÃO DE MASCULINIDADES: ANÁLISE DAS RELAÇÕES PRESENTES EM UMA TURMA DE ESCOLA PÚBLICA
Authors: Corso von Eye Carol , Junqueira Heloísa
Published: February 2021

No percurso escolar, o ser aluno se dá de forma diferente para meninos e meninas. Ser um bom aluno e se constituir como o menino esperado socialmente, pode ser muito improvável. Buscou-se analisar a formação de masculinidades no cotidiano de uma escola pública, Porto Alegre, RS, e seus efeitos na constituição identitária dos meninos. Considerando o caráter discreto da pedagogia da sexualidade, realizou-se uma pesquisa qualitativa com estudantes de uma turma de nono ano, objetivando contribuir aos estudos sobre formação de masculinidades. Os dados obtidos através de observação participante das relações escolares, e de entrevistas com professoras da turma observada, foram organizados em uma narrativa empírica, discutida e analisada sob pressupostos da análise de conteúdo. Teorizam-se algumas violências constituintes do ‘virar homem’ na escola e suas implicações na identidade, comportamento e saúde dos meninos.PALAVRAS-CHAVE: Masculinidades. Escola pública. Identidade. Relações de gênero.
DIREITOS HUMANOS NA BASE NACIONAL COMUM CURRICULAR: RESISTÊNCIAS PARA O TRABALHO DOCENTE
Authors: Xavier Filha Constantina
Published: February 2021

O artigo discute presenças e ausências dos direitos humanos no texto da Base Nacional Comum Curricular (BNCC) de 2017, procurando saber como tal temática é enfocada no documento e que outros documentos legais e oficiais legitimam possíveis resistências para o trabalho docente com crianças. O documento foi lido em sua integralidade e mapeada a palavra ‘direitos humanos’ em seu texto em todas as disciplinas e eixos da Educação Infantil ao 5º. Ano do Ensino Fundamental, excetuando apenas a disciplina de Ensino Religioso, que não foi incluída nessa edição. Apesar do entendimento de que os direitos humanos possam perpassar muitos temas e conceitos curriculares, além da presença do seu termo, pretendeu-se observar como ele foi cunhado e priorizado no documento. O texto tem por propósito pensar sobre essas questões, especificamente nas resistências possíveis para legitimar o trabalho docente em instituições educativas com crianças.
MULHERES NAS CIÊNCIAS: AÇÕES EDUCATIVAS PARA A REFLEXÃO DO PAPEL DAS MULHERES NO UNIVERSO DAS CIÊNCIAS
Authors: Arend Karine , Silva Maria Luiza Machado
Published: February 2021

As mulheres nem sempre foram representadas nas ciências como deveriam. Muitas contribuições femininas em pesquisas foram negligenciadas na história. Este é um dos fatores da baixa procura das meninas por cursos nas áreas das Ciências, Tecnologia, Engenharia e Matemática. Neste contexto, o projeto “Mulheres que mudarão o mundo” teve como objetivo oferecer um espaço de discussão, resgate, aprendizado e integração para aproximar as meninas do universo das ciências, ampliando seu interesse por essas áreas. Foram realizadas conversas e oficinas com temas de áreas da ciência com alunas do Ensino Médio em duas escolas estaduais e uma federal de São Bento do Sul/SC. A experiência serviu para a reflexão acerca do papel das mulheres no desenvolvimento das ciências e alcançou resultados positivos, motivando as participantes a repensar seu papel no mundo das ciências.
Preface to the Persian Edition of The Ecological Revolution
Authors: Foster John Bellamy
Published: February 2021

The Ecological Revolution was first published a little more than ten years ago in April 2009, at a time when climate change had already been recognized as a pressing global issue for over two decades, but when there was still hardly any realistic discussion of its connection to capitalism or of the immense ecological and social revolution that would be required to overcome the Earth System crisis. Let us look back to understand the historical gulf separating that time from our own.
On Creative Destruction, Myths, and Revolution
Authors: Feldman David E.
Published: February 2021

It is a testament to the clarity and scope of Mark Jay and Philip Conklin's vision that A People's History of Detroit is replete with insights for those trying to make sense of these deeply uncertain and troubling times. In it, Jay and Conklin show that "in order to give a true 'people's history,' one must do more than condemn the malevolence of those in power and celebrate the activists who have struggled for justice; one must also come to terms with the social system in which these people lived. In our case, this means confronting the logic of capital."
Morfologi, Anatomi dan Indeks Ekologi Bulu Babi di Pantai Sepanjang, Kabupaten Gunungkidul, Yogyakarta
Authors: Suryanti Suryanti , Fatimah Prasasti Nusa Pertiwi Nur , Rudiyanti Siti
Published: February 2021

Pantai Sepanjang memiliki karakteristik pantai dengan substrat berupa pasir dan hamparan karang mati yang banyak ditumbuhi makroalga, merupakan habitat berbagai jenis biota, salah satunya bulu babi. Biota tersebut memiliki fungsi ekologi sebagai pemakan detritus dan pengendali populasi makroalga di ekosistem terumbu karang. Tujuan penelitian ini untuk mengetahui jenis, morfologi, anatomi, dan kelimpahan bulu babi serta hubungannya dengan parameter lingkungan. Penelitian dilaksanakan pada bulan November 2019 di Pantai Sepanjang, Kabupaten Gunungkidul. Metode sampling menggunakan stratified random sampling dengan membagi lokasi pengamatan menjadi 3 stasiun (A, B, C) berdasarkan perbedaan tutupan substrat dasar perairan. Pengamatan dilakukan terhadap jenis, morfologi, anatomi, kelimpahan dan parameter lingkungan. Hasil penelitian ditemukan 6 jenis Bulu Babi yaitu Echinometra mathaei, Echinometra oblonga, Echinothrix calamaris, Heterocentrotus trigonarius, Diadema setosum dan Stomopneustes variolaris. Enam Jenis Bulu Babi tersebut memiliki karakteristik morfologi dan anatomi yang berbeda. Kelimpahan bulu babi pada stasiun A sebesar 474 ind/ 15m2, stasiun B sebesar 611 ind/ 15m2 dan stasiun C sebesar 81 ind/ 15m2. Berdasarkan Uji korelasi  menunjukkan bahan organik sedimen berkorelasi positif, sedangkan tekstur sedimen, suhu, salinitas berkorelasi negatif  dengan kelimpahan bulu babi. Sepanjang Beach has the characteristics of sand substrates and covered by dead corals, which are overgrown by macroalgae, and is a habitat for various types of biota, one of them sea urchins. This biota has an ecological function as a detritus feeder and macroalgae population controller in a coral reef ecosystem. The aims of the study is to determine the type, morphology, anatomy, and the linkage between the abundance of sea urchins to environmental parameters. The study was conducted in November 2019 at Sepanjang Beach, Gunungkidul Regency. The stratified random sampling was applied as sampling method, by dividing the observation location into 3 stations (A, B, C) based on the difference coverage of substrate. The observation covers the type, morphology, anatomy, abundance, and the environmental parameter. There were 6 sea urchins species namely Echinometra mathaei, Echinometra oblonga, Echinothrix calamaris, Heterocentrotus trigonarius, Diadema setosum and Stomopneustes variolaris, which have different characteristics of morphology and anatomy. The abundance of sea urchins at station A is 474 ind/ 15m2, station B is 611 ind/ 15m2, and station C is 81 ind/ 15m2. The sediment organic material and the abundance of sea urchins showed a significant correlation, while sediment texture, temperature, salinity have an insignificant correlation to the abundance of sea urchins.
Ecological evaluation of microelements in Astrakhan region and the dynamics of microelements in organs and tissues of Soviet Merino sheep
Authors: Ahmed M. A. , Vorobyov V. I. , Vorobyov D. V.
Published: February 2021

Microelements are important for stabilizing cell structures, but in deficient conditions they can stimulate alternative pathways and cause disease. This study was aimed to presents the monitoring data on the biogeochemical situation of pasture ecosystems in the Astrakhan region, southern Russia. Microelements in the collected samples from the pasture ecosystem, as well as the organs and tissues of Soviet Merino sheep, were determined by atomic absorption method. It was found a low level of microelements in soil, plants and forages of the ecosystem in the Astrakhan region. In addition, it was found a low level of microelements (selenium, iodine, and cobalt) in the organs and tissues of Merino sheep. Hypomicroelementosis in sheep leads to oxidative stress in animals, lower productivity and decrease the immunity of animals, which can be a predisposing for other diseases.
The Effects on Screw Fasteners Spacing on Flexural Behavior and Strength Capacity of Cold-Formed Steel Built-Up Box Sections
Authors: Making Maria Yasinta Menge , Awaludin Ali , Supriyadi Bambang
Published: February 2021

The capacity and behaviour of cold-formed steel built-up sections are affected by the arrangement of the connections. This study aims to determine the effect of the screw spacing to the bending capacity and behaviour of the cold-formed steel built-up box section which made from lipped-channel (1.0 mm thick, 81 mm web height, 8.5 mm lip height, upper and lower wing width 38 mm and 40 mm). A total of 19 beams with a length of 1200 mm each are subjected to pure bending moments by applying two point loads spaced 600 mm in the midspan. The screw spacing variations in the moment span are 100 mm, 150 mm, 200 mm, 250 mm, 300 mm, 328 mm, and 350 mm. The test results show the average of bending capacity of the beam test is increasing with the reduction in screw spacing while the screw configuration also affects the beam capacity. Analysis of the bending capacity using the effective width method and the direct strength method based on AISI S100-16 gives very conservative results. The failure mode of the built-up box sections were observed in the form of local buckling, distortion, and lateral-torsional buckling.
The role of urban branding to attract foreign tourists
Authors: Anjomrouz Elaheh , Dehyadegari Saeid , Hosseini Khaterehsadat , Anjomrouz Hoda
Published: February 2021

In today's world, Abstract City-marketing and urban-branding strategies play an essential role in the tourism industry. Tourism activists compete with each other to attract more tourists to their attractions. In promoting a touristic attraction, branding, both physical and spiritual aspects are crucial. Developing tourism infrastructures, built heritage, iconic architecture is essential as well as reinforcement of historical references, an attractive way of life, or cultural values. Since Certain cities are attracting all of the assets and the attention, while others are becoming more or less invisible, one of the critical prerequisites for the success of cities is their overall image, or so-called „city branding.“ In this research, we tried to investigate the urban branding of Kerman-a touristic and historical city located in the south of Iran- and its role in attracting foreign tourists toward this destination. After gathering data through library and field studies and analyzing data, we come to this result that urban branding has a crucial role in attracting foreign tourists to this town. The out coming from the subsidiary hypothesis tests showed that the six aspects of branding effects on attracting tourists. Our results could be useful for promoting Kerman tourism attractions.
Palmitoylation Controls NMDA Receptor Function and Steroid Sensitivity
Authors: Hubalkova Pavla , Ladislav Marek , Vyklicky Vojtech , Smejkalova Tereza , Hrcka Krausova Barbora , Kysilov Bohdan , Krusek Jan , Naimová Zaneta , Korinek Miloslav , Chodounska Hana , Kudova Eva , Cerny Jiri , Vyklicky Ladislav
Published: February 2021

NMDARs are ligand-gated ion channels that cause an influx of Na+and Ca2+into postsynaptic neurons. The resulting intracellular Ca2+transient triggers synaptic plasticity. When prolonged, it may induce excitotoxicity, but it may also activate negative feedback to control the activity of NMDARs. Here, we report that a transient rise in intracellular Ca2+(Ca2+challenge) increases the sensitivity of NMDARs but not AMPARs/kainate receptors to the endogenous inhibitory neurosteroid 20-oxo-5β-pregnan-3α-yl 3-sulfate and to its synthetic analogs, such as 20-oxo-5β-pregnan-3α-yl 3-hemipimelate (PAhPim). In cultured hippocampal neurons, 30 μmPAhPim had virtually no effect on NMDAR responses; however, following the Ca2+challenge, it inhibited the responses by 62%; similarly, the Ca2+challenge induced a 3.7-fold decrease in the steroid IC50on recombinant GluN1/GluN2B receptors. The increase in the NMDAR sensitivity to PAhPim was dependent on three cysteines (C849, C854, and C871) located in the carboxy-terminal domain of the GluN2B subunit, previously identified to be palmitoylated (Hayashi et al., 2009). Our experiments suggested that the Ca2+challenge induced receptor depalmitoylation, and single-channel analysis revealed that this was accompanied by a 55% reduction in the probability of channel opening. Results ofin silicomodeling indicate that receptor palmitoylation promotes anchoring of the GluN2B subunit carboxy-terminal domain to the plasma membrane and facilitates channel opening. Depalmitoylation-induced changes in the NMDAR pharmacology explain the neuroprotective effect of PAhPim on NMDA-induced excitotoxicity. We propose that palmitoylation-dependent changes in the NMDAR sensitivity to steroids serve as an acute endogenous mechanism that controls NMDAR activity.

SIGNIFICANCE STATEMENTThere is considerable interest in negative allosteric modulators of NMDARs that could compensate for receptor overactivation by glutamate orde novogain-of-function mutations in neurodevelopmental disorders. By a combination of electrophysiological, pharmacological, and computational techniques we describe a novel feedback mechanism regulating NMDAR activity. We find that a transient rise in intracellular Ca2+increases NMDAR sensitivity to inhibitory neurosteroids in a process dependent on GluN2B subunit depalmitoylation. These results improve our understanding of the molecular mechanisms of steroid action at the NMDAR and indeed of the basic properties of this important glutamate-gated ion channel and may aid in the development of therapeutics for treating neurologic and psychiatric diseases related to overactivation of NMDARs without affecting normal physiological functions.
A Trans Historiography of Glitches and Errors
Authors: Pow Whitney (Whit)
Published: February 2021

In 1978, queer and transgender programmer Jamie Faye Fenton created the first piece of experimental video glitch art, Digital TV Dinner, using the Bally Astrocade, a home computer and game console of her own design that was, for six months, the cheapest home computer available. Digital TV Dinner stands as a record of computational failure: it was created by Fenton through a pointed misuse of the computer system that caused the screen to dissolve into waves of pixelated glitches. What might it mean to center the glitch as a historically trans mode of media production? And how might we write trans media history as a history of unmediation—that is, a history of undoing mediation? A history of things that cannot be documented, or that evade or dismantle mediation, in which the fullness of trans life and history exceeds the images presented in the screen itself?
Life in-between Screens
Authors: Zhen Zhang , Jiehong Jiang , Chang Ellen Y.
Published: February 2021

This conversation, originally conducted in Chinese, explores the role of films, movie theaters, screens, streaming platforms, and documentary filmmaking in China during the initial wave of the COVID-19 pandemic. Zhang Zhen and Jiang Jiehong—professors at Tisch School of the Arts, New York University, and Birmingham City University, UK, respectively—discuss the human rights movement prompted by state-sanctioned racist violence, feminist interventions in filmmaking practices, documentation of the pandemic in China, and tensions between state discourse and minjian (unofficial, unaffiliated, grassroots, and among-the-people) narratives.
Legitimating New Religiosity in Contemporary Russia
Authors: Sadovina Irina
Published: February 2021

Attitudes toward alternative spirituality in Russia are shaped by legislative limitations on religious freedom, the state’s traditionalism, and Russian Orthodox anticultism. Nevertheless, public personalities associated with new religious movements persist and flourish. Oleg Torsunov, popularizer of Vedic Psychology and holistic medicine, is a striking example. Despite ongoing controversies about his religious affiliation, medical claims, and gender ideology, Torsunov continues to attract followers. This article examines why public figures such as Torsunov seem unsinkable in hostile cultural environments. Mapping the heated discursive landscape surrounding Torsunov, I argue that the secret to this resilience is a “legitimation lattice”—the strategy of grounding one’s authority in several sources of legitimacy. Torsunov’s lattice is composed of different interlocked strips: science, Indian spirituality, personal charisma, and common stereotypes. This structure increases the resilience of controversial public figures in two ways: by making their legitimation strategies flexible and by allowing them to emphasize mainstream values as needed.
The Effect of Fluoroscopy Control on Cannulation Rate and Fluoroscopy Time in Endoscopic Retrograde Cholangiopancreatography Training
Authors: Kim Raymond E. , Uradomo Lance T. , Kim Grace E. , Morris John D. , Goldberg Eric M. , Darwin Peter E.
Published: February 2021

Background/Aim: Endoscopic retrograde cholangiopancreatography (ERCP) training requires varying degrees of staff assistance regarding operation of the fluoroscopy machine via a foot pedal. Efficiency is important to acquire during this training due to radiation risks. In this study, we evaluate the effect of controlling endoscopy and fluoroscopy unit on duct cannulation rates (CRs) and total fluoroscopy time (FT) for fellows in training.Methods: 204 patients undergoing ERCP were randomized to one of two groups: 1) “Endoscopist Driven” group in which the endoscopist controlled the foot pedal for fluoroscopy, and 2) “Assistant Driven” group in which attending or fellow controlled the foot pedal while the other team member controlled the endoscope. Various measures including selective duct CR and total FT were recorded.Results: There was no significant difference in mean procedure duration between the two groups (32 minutes vs. 33 minutes, p=0.70). There was also no statistically significant difference in CR (83.7% vs. 77.4%, p=0.25) or FT (3.27 minutes vs. 3.54 minutes, p=0.48).Conclusions: ERCP is a technically challenging procedure which requires extensive supervision. This study demonstrates that CR and FT are not affected by who controls the fluoroscopy.
Is there a need for liver enzyme monitoring in people using gender-affirming hormone therapy?
Authors: A Stangl Theresa , M Wiepjes Chantal , Defreyne Justine , Conemans Elfi , D Fisher Alessandra , Schreiner Thomas , T’Sjoen Guy , den Heijer Martin
Published: February 2021

Context

Individuals with gender dysphoria can receive gender-affirming hormone therapy. Different guidelines mention a severe risk of liver injury within the first months after the start of treatment with anabolic androgenic steroids, anti-androgens, and oral contraceptives, which is potentially fatal.

Objective

The incidence of liver injury in a transgender population using gender-affirming hormone therapy.

Design

Multicentre prospective study with 1933 transgender individuals, who started with hormone therapy between 2010 and 2020.

Methods

The following parameters were analysed before hormone therapy, after 3 months, and after 12 months of hormone therapy: alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and gamma-glutamyltransferase (GGT). Both male and female reference values were considered. Liver injury was defined as either an elevation of 2× upper limit of normal (ULN) of ALP, 3× ULN of ALT, or 3× ULN of AST.

Results

889 transgender women and 1044 transgender men were included in the analysis. The incidence of liver injury within 12 months after the start of hormone therapy, without attribution to alcohol abuse, medical history, or comedication was 0.1 and 0.0%. in transgender women according to female and male reference intervals respectively, and 0.6 and 0.4% in transgender men (female and male reference intervals).

Conclusion

The incidence of liver injury is found to be very low. We, therefore, conclude that liver enzyme monitoring within the frame of the risk of liver injury due to hormone therapy is not necessary for a transgender population.
MCM7 as a marker of postsurgical progression in non-functioning pituitary adenomas
Authors: Hallén Tobias , Olsson Daniel S , Hammarstrand Casper , Örndal Charlotte , Engvall Angelica , Ragnarsson Oskar , Skoglund Thomas , Johannsson Gudmundur
Published: February 2021

Objective

Current markers predicting tumour progression of pituitary adenomas after surgery are insufficient. Our objective was to investigate if minichromosome maintenance protein 7 (MCM7) expression predicts tumour progression in non-functioning pituitary adenomas (NFPAs).

Methods

In a cohort study of surgically treated NFPAs, two groups with distinctly different behaviour of a residual tumour were selected: one group requiring reintervention due to tumour progression (reintervention group, n  = 57) and one with residual tumours without progression (radiologically stable group, n  = 40). MCM7, Ki-67, oestrogen receptor-α expression, mitotic index and tumour subtype were assessed by immunohistochemistry, and their association with tumour progression requiring reintervention was analysed.

Results

Median (IQR) MCM7 expression was 7.4% (2.4–15.2) in the reintervention group compared with 2.0% (0.6–5.3) in the radiologically stable group (P <0.0001). Cox regression analysis showed an association between high (>13%) MCM7 expression and reintervention (HR: 3.1; 95% CI:1.7–5.4; P  = 0.00012). The probability for reintervention within 6 years for patients with high MCM7 was 93%. Ki-67 expression >3% (P = 0.00062), age ≤55 years (P  = 0.00034) and mitotic index≥1 (P = 0.024) were also associated with reintervention. Using a receiver operating characteristics curve, a predictive model for reintervention with all the above predictors yielded an area under the curve of 82%. All eight patients with both high MCM7 and high Ki-67 needed reintervention.

Conclusion

This cohort study shows that expression of MCM7 is a predictor for clinically significant postoperative tumour progression. Together with age, Ki-67 and mitotic index, MCM7 might be of added value as a predictive marker when managing patients with NFPA after surgery.
Microfluidic approaches for synthetic gene circuits’ construction and analysis
Authors: Zhang Fengyu , Sun Yanhong , Luo Chunxiong
Published: February 2021

Background

Microfluidic systems have advantages such as a high throughput, small reaction volume, and precise control of the cellular position and environment. These advantages have allowed microfluidics to be widely used in several fields of synthetic biology in recent years.

Results

In this article, we reviewed the microfluidic‐based methods for synthetic biology from two aspects: the construction of synthetic gene circuits and the analysis of synthetic gene systems. We used some examples to illuminate the progresses and challenges in the steps of synthetic gene circuits construction and approaches of gene expression analysis with microfluidic systems.

Conclusion

Comparing to traditional methods, microfluidic tools promise great advantages in the synthetic genetic circuit building and analysis process. Moreover, new microfluidic systems together with the mathematical modeling of synthetic circuits or consortiums are desirable to perform complex genetic circuit construction and understand the natural gene regulation in cells and population interactions better.
Presentación de Signo Distintivo Semillero SIPA
Authors: Miguel Andrés Riveros Romero , Diana Lorena Galeano Rodríguez , Amable José Pérez , Mario Fernando Prieto Delgadillo
Published: February 2021

El documento da cuenta de la presentación del signo distintivo del semillero SIPA
Socialización Memorias de las Ferias de Emprendimiento y Empresarismo de Alto Impacto CAU Villavicencio 2016-2020.
Authors: Laura Lorena Araujo Medina , William Peñaranda Zárate , Jorge Alberto Ojeda Cortés , Mariana Torres Saavedra
Published: February 2021

Este documento da cuenta de la Socialización Memorias de las Ferias de Emprendimiento y Empresarismo de Alto Impacto CAU Villavicencio 2016-2020.
Ponencia - Fredy Leonardo Reyes Albarracin - Buenos Aires, Argentina - 2015
Authors: Fredy Leonardo Reyes Albarracin
Published: February 2021

Informe de movilidad académica. Participación en la V Jornada de Memoria del Núcleo de Estudios sobre Memoria. Universidad Nacional General de Sarmiento (UNGS) e Instituto de Desarrollo Económico y Social (IDES), Argentina
Family Background, Parent Involvement, and Shadow Education Participation of Middle School Students: Empirical Analysis from CEPS2015 Data
Authors: Gao Xiang , Xue Haiping
Published: February 2021

Using the 2015 data of the China Education Panel Survey (CEPS), the relationship between family socioeconomic background, parent involvement, and shadow education participation was explored through structural equations. The results showed that: parent involvement strengthened shadow education participation; parent involvement played a part in the mediating role in the influence of family socioeconomic background on shadow education participation. Parent involvement activates the advantage of family socioeconomic background. Families with high socioeconomic backgrounds are more active in participating in shadow education, and families of different strata are divided into opportunities for participation in shadow education.
The Non-Intellectual Norm of Middle School Students’ Mathematics Learning and Its Grade Evaluation Standard: Taking Tianjin as an Example
Authors: Wang Guangming , Li Jian , Jian Jingxian
Published: February 2021

Using the "Middle School Student Mathematics Learning Non-intellectual Questionnaire," a total of 1,400 middle school students in 11 districts and counties of Tianjin were surveyed. According to the data, using the raw score normalization method and the formula “T = 50+10×Z”, the middle school student mathematics learning non-intellectual population and its sub-dimensions norm table were established the corresponding grade evaluation standard was determined. The results of applied research were analyzed for class and individual application cases, and corresponding suggestions were made based on the analysis results.
Mnemonic Techniques and Lie Detection: Accuracy of Truth and Deception Judgments in Repeated Accounts
Authors: Izotovas Aleksandras , Vrij Aldert , Strömwall Leif A.
Published: February 2021

This study was an examination into whether the use of memory-enhancing techniques (mnemonics) in interviews can be helpful to distinguish truth tellers from liars. In the previous study (Izotovas et al., 2018), it was found that when mnemonic techniques were used in the interview immediately after the event, truth-tellers reported more details than liars in those immediate interviews and again after a delay. Moreover, truth-tellers, but not liars, showed patterns of reporting indicative of genuine memory decay.

In the current experiment, participants (n = 92) were asked to read the repeated statements reported by participants in the Izotovas et al.’s (2018) study and decide whether the statements they read were truthful or deceptive. One group of participants (informed condition) received information about the findings of the previous study before reading the statement. The other group received no information before reading the statement (uninformed condition). After participants made veracity judgements, they were asked an open-ended question asking what factors influenced their credibility decision. Although truthful statements were judged more accurately in the informed condition (65.2%) than in the uninformed condition (47.8%), this difference was not significant. In both conditions deceptive statements were detected at chance level (52.2%). Participants who relied on the self-reported diagnostic verbal cues to deceit were not more accurate than participants who self-reported unreliable cues. This could happen because only the minority of participants (27.4%) in both conditions based their decisions on diagnostic cues to truth/deceit.
Oral homeostasis, kill the microbiome or not?
Authors: Tomi Kupka Tomasz
Published: February 2021

The objective is to short review the current state of the art of dental antimicrobial agents in term of minimal invasive restorative dentistry. An outline of the most important aspects of dental antimicrobial agents was created, and a subsequent literature search for articles related was conducted. The current state of the art of antimicrobial agents includes a variety of species with broad ranges of properties. There is no agreement as to the choice of substances and concentration, however, there is a growing consensus regarding the need to use antimicrobial agents as additions into dental restorative materials’ compound in patients with high intensity of active caries disease.
Estimation of status of small rodents’ natural populations from the transformed ecosystems of the Chornobyl exclusion zone according to the complex of biological indicators
Authors:   Institute for Nuclear Research, National Academy of Sciences of Ukraine, Kyiv, Ukraine, Lypska A.I. , Rodionova N.K. , Riabchenko N.M. , Burdo O.O. , Vyshnevskiy D.O. , Ishiniwa H. ,   Chornobyl Radiation and Ecological Biosphere Reserve, Chornobyl, Ukraine,   Fukushima University, Fukushima, Japan
Published: February 2021

Morphophysiological and hematological parameters of different species and ontogenesis types of mice rodents from the drained areas of the Chornobyl cooling pond were studied for the first time; comparative analysis, including data of control and stable populations of the Chornobyl exclusion zone, was performed. Radioecological characterization of the research sites was carried out; the contents of the main dose-forming radionuclides were determined; animals’ exposure doses were estimated. In all experimental groups, similar changes in the hematopoietic system were observed, however, pathological features were less pronounced in individuals from the drained areas of the cooling pond. It was revealed that in the animal body under the chronic low dose exposure activation of compensatory and recovery processes occurs along with the destructive processes. It has been shown that the lifetime increase in radiation exposure of mature animals causes the imbalance of bone marrow hematopoiesis with the gradual exhaustion of blood system potential.
Characteristics of Pediatric Rapid Response Systems: Results From a Survey of PRIS Hospitals
Authors: Lockwood Justin M. , Ziniel Sonja I. , Bonafide Christopher P. , Brady Patrick W. , O’Leary Sean T. , Reese Jennifer , Wathen Beth , Dempsey Amanda F.
Published: February 2021

BACKGROUND:

Many hospitals use rapid response systems (RRSs) to identify and intervene on hospitalized children at risk for deterioration.

OBJECTIVES:

To describe RRS characteristics across hospitals in the Pediatric Research in Inpatient Settings (PRIS) network.

METHODS:

We developed the survey through a series of prospective respondent, expert, and cognitive interviews. One institutional expert per PRIS hospital (n = 109) was asked to complete the web survey. We summarized responses using descriptive statistics with a secondary analysis of univariate associations between RRS characteristics and perceived effectiveness.

RESULTS:

The response rate was 72% (79 of 109). Respondents represented diverse hospital types and were primarily physicians (97%) with leadership roles in care escalation. Many hospitals used an early warning score (77%) for identification with variable characteristics (46% automated versus 54% full or partially manual calculation; inputs included vital signs [98%], physical examination findings [88%], diagnoses [23%], medications [19%], and diagnostic tests [14%]). Few incorporated a validated prediction model (9%). Similarly, many RRSs used a rapid response team for intervention (93%) with variable team composition (respiratory therapists [94%], ICU nurses [93%], ICU providers [67%], and pharmacists [27%]). Some used the early warning score to trigger the rapid response team (50%). Only a few staffed a clinician to proactively surveil hospitalized children for risk of deterioration (18%), and these tended to be larger hospitals (annual admissions 12 000 vs 6000, P = .007). Most responding experts stated their RRSs improved patient outcomes (92%).

CONCLUSIONS:

RRS characteristics varied across PRIS hospitals.
Most Children With Medical Complexity Do Not Receive Care in Well-Functioning Health Care Systems
Authors: Yu Justin A. , McKernan Gina , Hagerman Thomas , Schenker Yael , Houtrow Amy
Published: February 2021

OBJECTIVES:

To describe the access of children with medical complexity (CMC) to well-functioning health care systems. To examine the relationships between medical complexity status and this outcome and its component indicators.

PATIENTS AND METHODS:

Secondary analysis of children in the National Survey of Children’s Health combined 2016–2017 data set who received care in well-functioning health systems. Secondary outcomes included this measure’s component indicators. The χ2 analyses were used to examine associations between child and family characteristics and the primary outcome. Adjusted multivariable logistic regression was used to examine relationships between medical complexity status and primary and secondary outcomes. Using these regression models, we examined the interaction between medical complexity status and household income.

RESULTS:

CMC accounted for 1.6% of the weighted sample (n = 1.2 million children). Few CMC (7.6%) received care in a well-functioning health care system. CMC were significantly less likely than children with special health care needs (CSHCN) (odds ratio, 0.3) of meeting criteria for this primary outcome. Attainment rates for secondary outcomes (families feeling like partners in care; receives care within a medical home; received needed health care) were significantly lower among CMC than CSHCN. Family income was significantly associated with likelihood of meeting criteria for primary and secondary outcomes; however, the relationships between medical complexity status and our outcomes did not differ by income level.

CONCLUSIONS:

CMC are less likely than other CSHCN to report receiving care in well-functioning health care systems at all income levels. Further efforts are necessary to better adapt current health care systems to meet the unique needs of CMC.
A case of newly diagnosed ulcerative colitis
Authors: Satılmış Mert , Aksoy Hilal
Published: February 2021

Ulcerative Colitis is an inflammatory bowel disease that is frequently encountered in young people, with an attack and can be diagnosed only with pathology. It is not among the first diagnoses that come to mind because of the low frequency of occurrence even in the presence of related symptoms in primary health care services. In our case, we presented a patient who was admitted to our Family Medicine Outpatient Clinic and was diagnosed after ulcerative colitis.
Towards Developing of Oberon System with Specific Requirements of Ergodicity
Authors: Dagaev Dmitry Victorovich
Published: February 2021

The ergodic system keeps the time average is the same for almost all initial points. It is important for computer systems to prevent the degradation of the properties of the system over time. Ergodicity is especially required for mission-critical systems in demanding industries. Software development based on the functional safety requirements of the IEC 60880 category A standard is implemented only on newly created software that meets the most stringent requirements for nuclear power plants, it is impossible to use standard operating systems and compilers. For these purposes, a prototype of the runtime environment and application software of the command display system (DSCU) was implemented. The runtime was created based on the Active Oberon A2 system. A2 is a single-user multi-tasking system. Application area - industrial embedded real-time systems, high reliability systems. The DSKU execution environment is implemented by a significant revision of the minimum subset A2 to meet the requirements of the standard. The system of restrictions formed according to the requirements of the standard makes it possible to create computer systems with new properties. The use of these constraints leads to the proof that there is no possibility of the occurrence of the failures they cause and allows us to consider a computer system based on the presumption of non-ergodicity. This «via negative» approach is based on restrictions, the addition of which allows one to obtain new qualitative properties. The more restrictions, the greater the gain in system reliability and stability.
A review on chemical and mechanical phenomena at the wafer interface during chemical mechanical planarization
Authors: Seo Jihoon
Published: February 2021

As the minimum feature size of integrated circuit elements has shrunk below 7 nm, chemical mechanical planarization (CMP) technology has grown by leaps and bounds over the past several decades. There has been a growing interest in understanding the fundamental science and technology of CMP, which has continued to lag behind advances in technology. This review paper provides a comprehensive overview of various chemical and mechanical phenomena such as contact mechanics, lubrication models, chemical reaction that occur between slurry components and films being polished, electrochemical reactions, adsorption behavior and mechanism, temperature effects, and the complex interactions occurring at the wafer interface during polishing. It also provides important insights into new strategies and novel concepts for next‐generation CMP slurries. Finally, the challenges and future research directions related to the chemical and mechanical process and slurry chemistry are highlighted.
Apresentação
Authors: Rivera Dario Paulo Barrera , De Souza Vitor Chaves
Published: February 2021

Por fim trazemos ao público o terceiro – e último – número da revista Estudos de Religião em 2020. Continuamos em tempos inéditos e pandêmicos em meio aos desafios constantes para mantermos a publicação periódica e rigorosa de pesquisas. Neste espírito, o presente número apresenta o dossiê internacional “Religião e literaturas contemporâneas de língua portuguesa”, organizado por Alex Villas Boas, da Universidade Católica Portuguesa, em Lisboa, José Rui Teixeira, da Universidade Católica Portuguesa, na cidade do Porto, Marcos Lopes, da Universidade Estadual de Campinas, e Marcio Cappelli, da Universidade Metodista de São Paulo, em São Bernardo do Campo.
O sensacionismo de Fernando Pessoa em diálogo com a análise religiosa da arte de Paul Tillich
Authors: Santos Joe Marçal G , Moura Ivanilton Aragão de
Published: February 2021

O presente artigo desenvolve uma análise do Sensacionismo da estética modernista do poeta Fernando (António Nogueira) Pessoa (Portugal, 1888-1935) em diálogo com a teologia da arte de Paul Tillich (1886-1965). O objetivo do mesmo é definir a relação entre religião e literatura na modernidade como problema investigativo para uma abordagem do Sensacionismo como ideia central da poética pessoana e chave de compreensão de sua proposta teórica modernista. Na condição de projeto estético, o Sensacionismo representou a essência do modernismo português em sua primeira geração, tomando a sensação como categoria determinante para a poética, a compreensão e a expressão da condição humana. Desse modo, o Sensacionismo fornecia a Pessoa uma compreensão hermenêutica da arte intrinsecamente vinculada à vida. A problemática da investigação, por sua vez, investe na identificação e na análise do significado existencial-religioso do modernismo de Pessoa. Para tal, em um primeiro momento, situaremos a relação entre religião e arte na filosofia da cultura e da religião de Paul Tillich, destacando a compreensão hermenêutica de ambas a partir desse quadro conceitual. Em um segundo momento, definiremos o Sensacionismo como o conjunto dos pressupostos teóricos que nortearam a produção literária de Fernando Pessoa, a partir de seu Manifesto Sensacionista, bem como de um conjunto de poemas heteronímicos. Por fim, identificaremos, em torno da compreensão hermenêutica da arte, o potencial analítico da obra pessoana na perspectiva da teologia da arte de Paul Tillich.