bluuebunny/crossref_metadata_2025 huggingface dataset:
High-Bandwidth Hysteresis Compensation of Piezoelectric Actuators via Multilayer Feedforward Neural Network Based Inverse Hysteresis Modeling
Authors: Qin Yanding , Zhang Yunpeng , Duan Heng , Han Jianda
Published: October 2021

This paper proposes a feedforward and feedback combined hysteresis compensation method for a piezoelectric actuator (PEA) based on the multi-layer feedforward neural network (MFNN) inverse model. Under the scheme of direct inverse modeling, the MFNN is utilized as the feedforward hysteresis compensator, which can be directly identified from the measurements. The high modeling accuracy and high robustness of the MFNN help to increase the bandwidth of the closed-loop system. Experiments are conducted on a commercial PEA so as to verify the effectiveness of the proposed method. The superimposition of two sinusoidal signals is found to be efficient for the training of the MFNN. Closed-loop trajectory tracking experiments demonstrate that the bandwidth can be increased up to 1000 Hz and the maximum deviation can be maintained closed to the noise level. Meanwhile, there are only two parameters to be tuned in the proposed method, which guarantees ease of use for the inexperienced users. The proposed method successfully realizes high-precision hysteresis compensation performance across a wider frequency range.
Development on Solid Polymer Electrolytes for Electrochemical Devices
Authors: Teo Li Ping , Buraidah Mohd Hamdi , Arof Abdul Kariem
Published: October 2021

Electrochemical devices, especially energy storage, have been around for many decades. Liquid electrolytes (LEs), which are known for their volatility and flammability, are mostly used in the fabrication of the devices. Dye-sensitized solar cells (DSSCs) and quantum dot sensitized solar cells (QDSSCs) are also using electrochemical reaction to operate. Following the demand for green and safer energy sources to replace fossil energy, this has raised the research interest in solid-state electrochemical devices. Solid polymer electrolytes (SPEs) are among the candidates to replace the LEs. Hence, understanding the mechanism of ions’ transport in SPEs is crucial to achieve similar, if not better, performance to that of LEs. In this paper, the development of SPE from basic construction to electrolyte optimization, which includes polymer blending and adding various types of additives, such as plasticizers and fillers, is discussed.
Pentacyclic Cytochalasins and Their Derivatives from the Endophytic Fungus Phomopsis sp. xz-18
Authors: Huang Guichon , Lin Weiwen , Li Hanpeng , Tang Qian , Hu Zhiyu , Huang Huiying , Deng Xianming , Xu Qingyan
Published: October 2021

Eight new cytochalasins 1–8 and ten known analogs 9–18 were isolated from the endophytic fungus Phomopsis sp. xz-18. The planar structures of the cytochalasins were determined by HR-ESI-MS and NMR analysis. Compounds 1, 2, 9 and 10 were 5/6/6/7/5-fused pentacyclic cytochalasins; compounds 3 and 4 had conjugated diene structures in the macrocycle; and compound 6 had a β,γ-unsaturated ketone. The absolute configuration of 6 was confirmed for the first time by the octant rule. The acid-free purification process proved that the pentacyclic system was a natural biosynthetic product and not an acid-mediated intramolecular cyclized artifact. The new compounds did not exhibit activities against human cancer cell lines in cytotoxicity bioassays or antipathogenic fungal activity, but compounds 1, 3 and 4 showed moderate antibacterial activity in disk diffusion assays.
Co-Precipitated Ni-Mg-Al Hydrotalcite-Derived Catalyst Promoted with Vanadium for CO2 Methanation
Authors: Summa Paulina , Świrk Katarzyna , Wierzbicki Dominik , Motak Monika , Alxneit Ivo , Rønning Magnus , Da Costa Patrick
Published: October 2021

Co-precipitated Ni-Mg-Al hydrotalcite-derived catalyst promoted with vanadium were synthesized with different V loadings (0–4 wt%) and studied in CO2 methanation. The promotion with V significantly changes textural properties (specific surface area and mesoporosity) and improves the dispersion of nickel. Moreover, the vanadium promotion strongly influences the surface basicity by increasing the total number of basic sites. An optimal loading of 2 wt% leads to the highest activity in CO2 methanation, which is directly correlated with specific surface area, as well as the basic properties of the studied catalysts.
Modeling Structure–Activity Relationship of AMPK Activation
Authors: Drewe Jürgen , Küsters Ernst , Hammann Felix , Kreuter Matthias , Boss Philipp , Schöning Verena
Published: October 2021

The adenosine monophosphate activated protein kinase (AMPK) is critical in the regulation of important cellular functions such as lipid, glucose, and protein metabolism; mitochondrial biogenesis and autophagy; and cellular growth. In many diseases—such as metabolic syndrome, obesity, diabetes, and also cancer—activation of AMPK is beneficial. Therefore, there is growing interest in AMPK activators that act either by direct action on the enzyme itself or by indirect activation of upstream regulators. Many natural compounds have been described that activate AMPK indirectly. These compounds are usually contained in mixtures with a variety of structurally different other compounds, which in turn can also alter the activity of AMPK via one or more pathways. For these compounds, experiments are complicated, since the required pure substances are often not yet isolated and/or therefore not sufficiently available. Therefore, our goal was to develop a screening tool that could handle the profound heterogeneity in activation pathways of the AMPK. Since machine learning algorithms can model complex (unknown) relationships and patterns, some of these methods (random forest, support vector machines, stochastic gradient boosting, logistic regression, and deep neural network) were applied and validated using a database, comprising of 904 activating and 799 neutral or inhibiting compounds identified by extensive PubMed literature search and PubChem Bioassay database. All models showed unexpectedly high classification accuracy in training, but more importantly in predicting the unseen test data. These models are therefore suitable tools for rapid in silico screening of established substances or multicomponent mixtures and can be used to identify compounds of interest for further testing.
Composition of Algerian Propolis, Plant Origin, and Its Antiangiogenic Activity In Vitro
Authors: Hosoya Takahiro , Tsuchiya Ikumi , Ohta Toshiro , Benhanifia Mokhtar , Kumazawa Shigenori
Published: October 2021

The antiangiogenic activity of the ethanol extract of propolis collected from different regions in western Algeria was investigated using in vitro human umbilical vein endothelial cells (HUVECs). The ethanol extract with the strongest activity, i.e., Algerian propolis 1 (EEPA1), inhibited the formation of capillary networks in a dose-dependent manner (6.25–50 μg/mL) within 12 h and induced cell fragmentation of HUVECs at 50 μg/mL after treatment for 24 h. To identify the active compounds in EEAP1, a high-performance liquid chromatography (HPLC) analysis was performed, revealing that EEAP1 contains two major compounds. Both compounds were isolated by repeated column chromatography and identified as ω-hydroxyferulenol (1) and ferulenol (2), which have a coumarin structure conjugated with a farnesyl group according to NMR, high-resolution electrospray ionization mass spectroscopy, and chemical modification. Compounds 1 and 2 inhibited the tube-forming activity of HUVECs, especially 2, which exhibited a stronger antiangiogenic effect even at a low concentration of 3.31 μg/mL. Moreover, 2 suppressed the elongation and induced cell fragmentation at the same dose. The molecular changes in tube-forming HUVECs induced by 2 were found to be related to the activation of the caspase signals. To confirm the plant origin of propolis, an HPLC comparative analysis of the ethanol extracts of some plants near beekeeping areas and that of Algerian propolis (EEAP1) was performed, and similar chromatographic patterns were observed. This result suggests that the plant origin of this Algerian propolis is the resin of Ferula communis.
X-ray Structure Determination, Antioxidant Voltammetry Studies of Butein and 2′,4′-Dihydroxy-3,4-dimethoxychalcone. Computational Studies of 4 Structurally Related 2′,4′-diOH Chalcones to Examine Their Antimalarial Activity by Binding to Falcipain-2
Authors: Okoye Ijeoma , Yu Sandra , Caruso Francesco , Rossi Miriam
Published: October 2021

Malaria is a huge global health burden with resistance to currently available medicines resulting in the search for newer antimalarial compounds from traditional medicinal plants in malaria-endemic regions. Previous studies on two chalcones, homobutein and 5-prenylbutein, present in E. abyssinica, have shown moderate antiplasmodial activity. Here, we describe results from experimental and computational investigations of four structurally related chalcones, butein, 2′,4′-dihydroxy-3,4-dimethoxychalcone (DHDM), homobutein and 5-prenylbutein to elucidate possible molecular mechanisms by which these compounds clear malaria parasites. The crystal structures of butein and DHDM show that butein engages in more hydrogen bonding and consequently, more intermolecular interactions than DHDM. Rotating ring-disk electrode (RRDE) voltammetry results show that butein has a higher antioxidant activity towards the superoxide radical anion compared to DHDM. Computational docking experiments were conducted to examine the inhibitory potential of all four compounds on falcipain-2, a cysteine protease that is involved in the degradation of hemoglobin in plasmodium-infected red blood cells of the host. Overall, this work suggests butein as a better antimalarial compound due to its structural features which allow it to have greater intermolecular interactions, higher antioxidant activity and to create a covalent complex at the active site of falcipain-2.
Evaluating High-Variance Leaves as Uncertainty Measure for Random Forest Regression
Authors: Dutschmann Thomas-Martin , Baumann Knut
Published: October 2021

Uncertainty measures estimate the reliability of a predictive model. Especially in the field of molecular property prediction as part of drug design, model reliability is crucial. Besides other techniques, Random Forests have a long tradition in machine learning related to chemoinformatics and are widely used. Random Forests consist of an ensemble of individual regression models, namely, decision trees and, therefore, provide an uncertainty measure already by construction. Regarding the disagreement of single-model predictions, a narrower distribution of predictions is interpreted as a higher reliability. The standard deviation of the decision tree ensemble predictions is the default uncertainty measure for Random Forests. Due to the increasing application of machine learning in drug design, there is a constant search for novel uncertainty measures that, ideally, outperform classical uncertainty criteria. When analyzing Random Forests, it appears obvious to consider the variance of the dependent variables within each terminal decision tree leaf to obtain predictive uncertainties. Hereby, predictions that arise from more leaves of high variance are considered less reliable. Expectedly, the number of such high-variance leaves yields a reasonable uncertainty measure. Depending on the dataset, it can also outperform ensemble uncertainties. However, small-scale comparisons, i.e., considering only a few datasets, are insufficient, since they are more prone to chance correlations. Therefore, large-scale estimations are required to make general claims about the performance of uncertainty measures. On several chemoinformatic regression datasets, high-variance leaves are compared to the standard deviation of ensemble predictions. It turns out that high-variance leaf uncertainty is meaningful, not superior to the default ensemble standard deviation. A brief possible explanation is offered.
Pyrene-Benzimidazole Derivatives as Novel Blue Emitters for OLEDs
Authors: De Silva Thenahandi Prasanthi Deepthika , Youm Sang Gil , Fronczek Frank R. , Sahasrabudhe Girija , Nesterov Evgueni E. , Warner Isiah M.
Published: October 2021

Three novel small organic heterocyclic compounds: 2-(1,2-diphenyl)-1H-benzimidazole-7-tert-butylpyrene (compound A), 1,3-di(1,2-diphenyl)-1H-benzimidazole-7-tert-butylpyrene (compound B), and 1,3,6,8-tetra(1,2-diphenyl)-1H-benzimidazolepyrene (compound C) were synthesized and characterized for possible applications as blue OLED emitters. The specific molecular design targeted decreasing intermolecular aggregation and disrupting crystallinity in the solid-state, in order to reduce dye aggregation, and thus obtain efficient pure blue photo- and electroluminescence. Accordingly, the new compounds displayed reasonably high spectral purity in both solution- and solid-states with average CIE coordinates of (0.160 ± 0.005, 0.029 ± 0.009) in solution and (0.152 ± 0.007, 0.126 ± 0.005) in solid-state. These compounds showed a systematic decrease in degree of crystallinity and intermolecular aggregation due to increasing steric hindrance, as revealed using powder X-ray diffraction analysis and spectroscopic studies. An organic light-emitting diode (OLED) prototype fabricated using compound B as the non-doped emissive layer displayed an external quantum efficiency (EQE) of 0.35 (±0.04)% and luminance 100 (±6) cd m−2 at 5.5 V with an essentially pure blue electroluminescence corresponding to CIE coordinates of (0.1482, 0.1300). The highest EQE observed from this OLED prototype was 4.3 (±0.3)% at 3.5 V, and the highest luminance of 290 (±10) cd m−2 at 7.5 V. These values were found comparable to characteristics of the best pure blue OLED devices based on simple fluorescent small-molecule organic chromophores.
Facile Construction of Bio-Based Supramolecular Hydrogels from Dehydroabietic Acid with a Tricyclic Hydrophenanthrene Skeleton and Stabilized Gel Emulsions
Authors: Lin Caiyun , Li Yuying , Tang Weishan , Zhou Shufeng , Rao Xiaoping
Published: October 2021

Supramolecular hydrogels have attracted great attention due to their special properties. In this research, bio-based supramolecular hydrogels were conveniently constructed by heating and ultrasounding two components of dehydroabietic acid with a rigid tricyclic hydrophenanthrene skeleton and morpholine. The microstructures and properties of hydrogels were investigated by DSC, rheology, SAXS, CD spectroscopy, and cryo-TEM, respectively. The critical gel concentration (CGC) of the hydrogel was 0.3 mol·L−1 and the gel temperature was 115 °C. In addition, the hydrogel showed good stability and mechanical properties according to rheology results. Cryo-TEM images reveal that the microstructure of hydrogel is fibrous meshes; its corresponding mechanism has been studied using FT-IR spectra. Additionally, oil-in-water gel emulsions were prepared by the hydrogel at a concentration above its CGC, and the oil mass fraction of the oil-in-water gel emulsions could be freely adjusted between 5% and 70%. This work provides a convenient way to prepare bio-based supramolecular hydrogels and provides a new method for the application of rosin.
Ursane-Type Triterpenes, Phenolics and Phenolic Derivatives from Globimetula braunii Leaf
Authors: Oriola Ayodeji Oluwabunmi , Aladesanmi Adetunji Joseph , Idowu Thomas Oyebode , Akinwumi Florence O. , Obuotor Efere Martins , Idowu Temilolu , Oyedeji Adebola Omowunmi
Published: October 2021

Globimetula braunii is a hemi-parasitic plant used in African ethnomedicine for the management of microbial infections, rheumatic pain and tumors amongst others. We report the isolation and characterization of eight compounds with their antioxidant and antimicrobial activities. The air-dried powdered leaf was macerated in EtOH/H20 (4:1). The extract was solvent-partitioned into n-hexane, EtOAc, n-BuOH and aqueous fractions. The fractions were screened for their antioxidant properties, using DPPH, FRAP, TAC and FIC assays. Antimicrobial analysis was performed using the micro-broth dilution method. The active EtOAc fraction was purified for its putative compounds on a repeated silica gel column chromatography monitored with TLC-bioautography. The isolated compounds were characterized using spectroscopic methods of UV, FT-IR, NMR and MS. Eight compounds (1–8) were isolated and characterized as 13,27-cycloursane (1), phyllanthone (2), globraunone (3), three phenolics: methyl 3,5-dihydroxy-4-methoxybenzoate (4), methyl 3-methyl-4-hydroxybenzoate (5) and guaiacol (6), as well as two phenol derivatives: 4-formaldehyde phenone (7) and 6-methoxy-2H-inden-5-ol (8). The study identified 4 and 6 as natural antioxidant compounds with potential as antimicrobial agents.
Rapid Identification between Two Fish Species Using UV-Vis Spectroscopy for Substitution Detection
Authors: Chai Zhaoliang , Wang Chengyu , Bi Hongyan
Published: October 2021

Fish species substitution and fraud has become a worldwide economic issue in the seafood industry. In this study, an ultraviolet-visible (UV-Vis) spectroscopy-based method was developed for the identification of fish samples. Sixty fish samples from twelve commonly consumed fish species in China were analyzed as models to testify the protocol. The obtained results show that UV-Vis spectroscopy combined with chemometric analysis, such as principal component analysis (PCA), can accurately distinguish two fish species by boiling fish tissue sample in trifluoroacetic acid (TFA) solution for 2 min and analyzing the resultant samples using a UV-Vis spectrometer. The developed strategy was successfully applied to the classification and identification of fish samples on the market. It is a promising strategy that can be applied to the classification and authenticity testing of closely related fish species in order to detect and recognize fish substitution.
Plasma Vitamin B12 and Folate Alter the Association of Blood Lead and Cadmium and Total Urinary Arsenic Levels with Chronic Kidney Disease in a Taiwanese Population
Authors: Hsueh Yu-Mei , Huang Ya-Li , Lin Yuh-Feng , Shiue Horng-Sheng , Lin Ying-Chin , Chen Hsi-Hsien
Published: October 2021

Heavy metals causing chronic nephrotoxicity may play a key role in the pathogenesis of chronic kidney disease (CKD). This study hypothesized that plasma folate and vitamin B12 would modify the association of CKD with total urinary arsenic and blood lead and cadmium levels. We recruited 220 patients with CKD who had an estimated glomerular filtration rate of <60 mL/min/1.73 m2 for ≥3 consecutive months and 438 sex- and age-matched controls. We performed inductively coupled plasma mass spectrometry to measure blood cadmium and lead levels. The urinary arsenic level was determined using a high-performance liquid chromatography–hydride generator–atomic absorption spectrometry. Plasma vitamin B12 and folate levels were measured through the SimulTRAC-SNB radioassay. Compared with patients with plasma vitamin B12 ≤ 6.27 pg/mL, the odds ratio (OR) and 95% confidence interval of CKD for patients with plasma vitamin B12 > 9.54 pg/mL was 2.02 (1.15–3.55). However, no association was observed between plasma folate concentration and CKD. A high level of plasma vitamin B12 combined with high levels of blood lead and cadmium level and total urinary arsenic tended to increase the OR of CKD in a dose-response manner, but the interactions were nonsignificant. This is the first study to demonstrate that patients with high plasma vitamin B12 level exhibit increased OR of CKD related to high levels of blood cadmium and lead and total urinary arsenic.
The Role of Obesity-Induced Perivascular Adipose Tissue (PVAT) Dysfunction in Vascular Homeostasis
Authors: Stanek Agata , Brożyna-Tkaczyk Klaudia , Myśliński Wojciech
Published: October 2021

Perivascular adipose tissue (PVAT) is an additional special type of adipose tissue surrounding blood vessels. Under physiological conditions, PVAT plays a significant role in regulation of vascular tone, intravascular thermoregulation, and vascular smooth muscle cell (VSMC) proliferation. PVAT is responsible for releasing adipocytes-derived relaxing factors (ADRF) and perivascular-derived relaxing factors (PDRF), which have anticontractile properties. Obesity induces increased oxidative stress, an inflammatory state, and hypoxia, which contribute to PVAT dysfunction. The exact mechanism of vascular dysfunction in obesity is still not well clarified; however, there are some pathways such as renin–angiotensin–aldosterone system (RAAS) disorders and PVAT-derived factor dysregulation, which are involved in hypertension and endothelial dysfunction development. Physical activity has a beneficial effect on PVAT function among obese patients by reducing the oxidative stress and inflammatory state. Diet, which is the second most beneficial non-invasive strategy in obesity treatment, may have a positive impact on PVAT-derived factors and may restore the balance in their concentration.
Time-Restricted Feeding in Mice Prevents the Disruption of the Peripheral Circadian Clocks and Its Metabolic Impact during Chronic Jetlag
Authors: Desmet Louis , Thijs Theo , Mas Rosalie , Verbeke Kristin , Depoortere Inge
Published: October 2021

We used time-restricted feeding (TRF) to investigate whether microbial metabolites and the hunger hormone ghrelin can become the dominant entraining factor during chronic jetlag to prevent disruption of the master and peripheral clocks, in order to promote health. Therefore, hypothalamic clock gene and Agrp/Npy mRNA expression were measured in mice that were either chronically jetlagged and fed ad libitum, jetlagged and fed a TRF diet, or not jetlagged and fed a TRF diet. Fecal short-chain fatty acid (SCFA) concentrations, plasma ghrelin and corticosterone levels, and colonic clock gene mRNA expression were measured. Preventing the disruption of the food intake pattern during chronic jetlag using TRF restored the rhythmicity in hypothalamic clock gene mRNA expression of Reverbα but not of Arntl. TRF countered the changes in plasma ghrelin levels and in hypothalamic Npy mRNA expression induced by chronic jetlag, thereby reestablishing the food intake pattern. Increase in body mass induced by chronic jetlag was prevented. Alterations in diurnal fluctuations in fecal SCFAs during chronic jetlag were prevented thereby re-entraining the rhythmic expression of peripheral clock genes. In conclusion, TRF during chronodisruption re-entrains the rhythms in clock gene expression and signals from the gut that regulate food intake to normalize body homeostasis.
Early-Life Iron Deficiency Anemia Programs the Hippocampal Epigenomic Landscape
Authors: Barks Amanda K. , Liu Shirelle X. , Georgieff Michael K. , Hallstrom Timothy C. , Tran Phu V.
Published: October 2021

Iron deficiency (ID) anemia is the foremost micronutrient deficiency worldwide, affecting around 40% of pregnant women and young children. ID during the prenatal and early postnatal periods has a pronounced effect on neurodevelopment, resulting in long-term effects such as cognitive impairment and increased risk for neuropsychiatric disorders. Treatment of ID has been complicated as it does not always resolve the long-lasting neurodevelopmental deficits. In animal models, developmental ID results in abnormal hippocampal structure and function associated with dysregulation of genes involved in neurotransmission and synaptic plasticity. Dysregulation of these genes is a likely proximate cause of the life-long deficits that follow developmental ID. However, a direct functional link between iron and gene dysregulation has yet to be elucidated. Iron-dependent epigenetic modifications are one mechanism by which ID could alter gene expression across the lifespan. The jumonji and AT-rich interaction domain-containing (JARID) protein and the Ten-Eleven Translocation (TET) proteins are two families of iron-dependent epigenetic modifiers that play critical roles during neural development by establishing proper gene regulation during critical periods of brain development. Therefore, JARIDs and TETs can contribute to the iron-mediated epigenetic mechanisms by which early-life ID directly causes stable changes in gene regulation across the life span.
Comparison of the 1-Year Visual and Anatomical Outcomes between Subthreshold Red (670 nm) and Yellow (577 nm) Micro-Pulse Laser Treatment for Diabetic Macular Edema
Authors: Kikushima Wataru , Shijo Taiyo , Furuhata Yukiko , Sakurada Yoichi , Kashiwagi Kenji
Published: October 2021

We investigated the efficacy and safety of red (670 nm) subthreshold micropulse laser (SMPL) treatment for diabetic macular edema (DME) and compared the 1-year treatment outcomes of red and yellow (577 nm) SMPL for DME. A medical chart review was performed in 43 consecutive eyes of 35 patients who underwent red or yellow SMPL treatment for DME and were followed up for 12 months. There were 26 and 17 eyes in the yellow and red SMPL groups, respectively. The mean best-corrected visual acuity (BCVA) was maintained throughout the follow-up period of 12 months in the yellow and red SMPL groups (p = 0.39, p = 0.70, respectively). The central retinal thickness (CRT) measured by spectral-domain optical coherence tomography (SD-OCT) was significantly decreased at 12 months from baseline in the yellow and red SMPL groups (p = 0.047, p = 0.03, respectively). Although the amount of CRT reduction in the red SMPL group was significantly greater than that in the yellow SMPL group at 8 months from baseline (p = 0.02), the significance disappeared at the final follow-up period (p = 0.44). The red SMPL maintained the BCVA in patients with center-involving DME. The mean CRT in the red SMPL group significantly decreased, and the amount of CRT reduction was equivalent to that in the yellow SMPL group.
Antiviral Activities of Andrographolide and Its Derivatives: Mechanism of Action and Delivery System
Authors: Adiguna Sya’ban Putra , Panggabean Jonathan Ardhianto , Atikana Akhirta , Untari Febriana , Izzati Fauzia , Bayu Asep , Rosyidah A’liyatur , Rahmawati Siti Irma , Putra Masteria Yunovilsa
Published: October 2021

Andrographispaniculata (Burm.f.) Nees has been used as a traditional medicine in Asian countries, especially China, India, Vietnam, Malaysia, and Indonesia. This herbaceous plant extract contains active compounds with multiple biological activities against various diseases, including the flu, colds, fever, diabetes, hypertension, and cancer. Several isolated compounds from A. paniculata, such as andrographolide and its analogs, have attracted much interest for their potential treatment against several virus infections, including SARS-CoV-2. The mechanisms of action in inhibiting viral infections can be categorized into several types, including regulating the viral entry stage, gene replication, and the formation of mature functional proteins. The efficacy of andrographolide as an antiviral candidate was further investigated since the phytoconstituents of A. paniculata exhibit various physicochemical characteristics, including low solubility and low bioavailability. A discussion on the delivery systems of these active compounds could accelerate their development for commercial applications as antiviral drugs. This study critically reviewed the current antiviral development based on andrographolide and its derivative compounds, especially on their mechanism of action as antiviral drugs and drug delivery systems.
Prophecy and Religion Revisited: John Skinner and Evangelical Biblical Criticism
Authors: Houston Walter J.
Published: October 2021

The paper is an essay in the history of interpretation. Its subject is John Skinner’s book on the life of Jeremiah, Prophecy and Religion (1922). The main aim is to place the work in its historical, theological and cultural context, to explain Skinner’s conviction that Jeremiah’s life marks the emergence of personal religion in Israel and points towards Christianity. Attempts at such contextualization by J. Henderson and M.C. Callaway are studied and shown to be inadequate. Skinner’s religious context and theological education are then reviewed and are shown to be sufficient to account for his belief in the pivotal role of Jeremiah in the evolution of ‘religion’. The paper finally addresses the present-day significance of Skinner’s work and concludes that while Prophecy and Religion is of limited value for the interpretation of Jeremiah, Skinner’s life and work as a whole as an evangelical believer engaged in radical biblical criticism is a valuable model neglected over the last 100 years.
(In)active God—Coping with Suffering and Pain from the Perspective of Christianity
Authors: Mijatović Franjo
Published: October 2021

Colloquially, suffering and pain are usually and exclusively concerned with the human body. Pain and suffering are clearly objective facts, as well as lasting and memorable experiences. Are suffering and pain purely biological phenomena and neurological states, or can they be interpreted by culture, religion, philosophy, sociology, Christianity, etc.? To what extent can it, therefore, be said that the body is sufficiently cognitively, motorically, and sensibly equipped to accept or reject unpleasant situations. Except biological, neurological, and medical, i.e., physical, views about suffering and pain, the Christian solution is one of the essential elements of human life which can serve as a bridge between adaptive and cognitive management and control of the body and mind and learned (parents, culture, society) patterns of dealing with pain and suffering. Our article aims to show how Christianity, in describing suffering and pain as the physiological fact and subjective experience, can be gathered up into a meaningful whole and a powerful sense of (in)active God.
On Satellite-Borne GPS Data Quality and Reduced-Dynamic Precise Orbit Determination of HY-2C: A Case of Orbit Validation with Onboard DORIS Data
Authors: Guo Hengyang , Guo Jinyun , Yang Zhouming , Wang Guangzhe , Qi Linhu , Lin Mingsen , Peng Hailong , Ji Bing
Published: October 2021

Haiyang-2C (HY-2C) is a dynamic, marine-monitoring satellite that was launched by China and is equipped with an onboard dual-frequency GPS receiver named HY2_Receiver, which was independently developed in China. HY-2C was successfully launched on 21 September 2020. Its precise orbit is an important factor for scientific research applications, especially for marine altimetry missions. The performance of the HY2_Receiver is assessed based on indicators such as the multipath effect, ionospheric delay, cycle slip and data utilization, and assessments have suggested that the receiver can be used in precise orbit determination (POD) missions involving low-Earth-orbit (LEO) satellites. In this study, satellite-borne GPS data are used for POD with a reduced-dynamic (RD) method. Phase centre offset (PCO) and phase centre variation (PCV) models of the GPS antenna are established during POD, and their influence on the accuracy of orbit determination is analysed. After using the PCO and PCV models in POD, the root mean square (RMS) of the carrier-phase residuals is around 0.008 m and the orbit overlap validation accuracy in each direction reaches approximately 0.01 m. Compared with the precise science orbit (PSO) provided by the Centre National d’Etudes Spatiales (CNES), the RD orbit accuracy of HY-2C in the radial (R) direction reaches 0.01 m. The accuracy of satellite laser ranging (SLR) range validation is better than 0.03 m. Additionally, a new method is proposed to verify the accuracy of the RD orbit of HY-2C by using space-borne Doppler orbitography and radiopositioning integrated by satellite (DORIS) data directly. DORIS data are directly compared to the result calculated using the accurate coordinates of beacons and the RD orbit, and the results indicate that the external validation of HY-2C RD orbit has a range rate accuracy of within 0.0063 m/s.
Optimal Grid-Based Filtering for Crop Phenology Estimation with Sentinel-1 SAR Data
Authors: Mascolo Lucio , Martinez-Marin Tomas , Lopez-Sanchez Juan M.
Published: October 2021

In the last decade, suboptimal Bayesian filtering (BF) techniques, such as Extended Kalman Filtering (EKF) and Particle Filtering (PF), have led to great interest for crop phenology monitoring with Synthetic Aperture Radar (SAR) data. In this study, a novel approach, based on the Grid-Based Filter (GBF), is proposed to estimate crop phenology. Here, phenological scales, which consist of a finite number of discrete stages, represent the one-dimensional state space, and hence GBF provides the optimal phenology estimates. Accordingly, contrarily to literature studies based on EKF and PF, no constraints are imposed on the models and the statistical distributions involved. The prediction model is defined by the transition matrix, while Kernel Density Estimation (KDE) is employed to define the observation model. The approach is applied on dense time series of dual-polarization Sentinel-1 (S1) SAR images, collected in four different years, to estimate the BBCH stages of rice crops. Results show that 0.94 ≤ R2 ≤ 0.98, 5.37 ≤ RMSE ≤ 7.9 and 20 ≤ MAE ≤ 33.
How Much Shallow Coral Habitat Is There on the Great Barrier Reef?
Authors: Roelfsema Chris M. , Lyons Mitchell B. , Castro-Sanguino Carolina , Kovacs Eva M. , Callaghan David , Wettle Magnus , Markey Kathryn , Borrego-Acevedo Rodney , Tudman Paul , Roe Meredith , Kennedy Emma V. , Gonzalez-Rivero Manuel , Murray Nicholas , Phinn Stuart R.
Published: October 2021

Australia’s Great Barrier Reef (GBR) is a globally unique and precious national resource; however, the geomorphic and benthic composition and the extent of coral habitat per reef are greatly understudied. However, this is critical to understand the spatial extent of disturbance impacts and recovery potential. This study characterizes and quantifies coral habitat based on depth, geomorphic and benthic composition maps of more than 2164 shallow offshore GBR reefs. The mapping approach combined a Sentinel-2 satellite surface reflectance image mosaic and derived depth, wave climate, reef slope and field data in a random-forest machine learning and object-based protocol. Area calculations, for the first time, incorporated the 3D characteristic of the reef surface above 20 m. Geomorphic zonation maps (0–20 m) provided a reef extent estimate of 28,261 km2 (a 31% increase to current estimates), while benthic composition maps (0–10 m) estimated that ~10,600 km2 of reef area (~57% of shallow offshore reef area) was covered by hard substrate suitable for coral growth, the first estimate of potential coral habitat based on substrate availability. Our high-resolution maps provide valuable information for future monitoring and ecological modeling studies and constitute key tools for supporting the management, conservation and restoration efforts of the GBR.
Medium- (MR) and Very-High-Resolution (VHR) Image Integration through Collect Earth for Monitoring Forests and Land-Use Changes: Global Forest Survey (GFS) in the Temperate FAO Ecozone in Europe (2000–2015)
Authors: García-Montero Luis Gonzaga , Pascual Cristina , Martín-Fernández Susana , Sanchez-Paus Díaz Alfonso , Patriarca Chiara , Martín-Ortega Pablo , Mollicone Danilo
Published: October 2021

Monitoring of land use, land-use changes, and forestry (LULUCF) plays a crucial role in biodiversity and global environmental challenges. In 2015, the Food and Agriculture Organization of the United Nations (FAO) launched the Global Forest Survey (GFS) integrating medium- (MR) and very-high-resolution (VHR) images through the FAO’s Collect Earth platform. More than 11,150 plots were inventoried in the Temperate FAO ecozone in Europe to monitor LULUCF from 2000 to 2015. As a result, 2.19% (VHR) to 2.77% (MR/VHR) of the study area underwent LULUCF, including a 0.37% (VHR) to 0.43% (MR/VHR) net increase in forest lands. Collect Earth and VHR images have also (i) allowed for shaping a preliminary structure of the land-use network, showing that cropland was the land type that changed most and that cropland and grassland were the more frequent land uses that generated new forest land, (ii) shown that, in 2015, mixed and monospecific forests represented 44.3% and 46.5% of the forest land, respectively, unlike other forest sources, and (iii) shown that 14.9% of the area had been affected by disturbances, particularly wood harvesting (67.47% of the disturbed forests). According to other authors, the area showed a strong correlation between canopy mortality and reported wood removals due to the transition from past clear-cut systems to “close-to-nature” silviculture.
IAS: A New Novel Phase-Based Filter for Detection of Unexploded Ordnances
Authors: Ibraheem Ismael M. , Aladad Hasan , Alnaser Mohamad Faek , Stephenson Randell
Published: October 2021

A new phase-based filter (called improved analytical signal (IAS)) is introduced to detect buried unexploded ordnance (UXO) precisely from magnetic fields using the arcsine function of the ratio of the first-order vertical derivative of the analytical signal to the first-order derivatives of the x-, y-, and z-components of the analytical signal. The calculations are computed in the frequency domain and then transformed back into the space domain using the inverse Fourier transform. The filter has been tested on magnetic data collected at a test site with UXO bodies of variable orientation. It was also validated on magnetic data measured at a former army artillery range in Slovakia. The results show that the IAS filter not only revealed better imaging of the UXO bodies compared to the other commonly used filters but also produced a high-resolution image with much less influence of noise.
LiDAR Positioning Algorithm Based on ICP and Artificial Landmarks Assistance
Authors: Zeng Qingxi , Kan Yuchao , Tao Xiaodong , Hu Yixuan
Published: October 2021

As one of the automated guided vehicle (AGV) positioning methods, the LiDAR positioning method, based on artificial landmarks, has been widely used in warehousing logistics industries in recent years. However, the traditional LiDAR positioning method based on artificial landmarks mainly depends on the three-point positioning method, the performance of which is limited due to landmarks’ layout and detection requirements. This paper proposes a LiDAR positioning algorithm based on iterative closest point (ICP) and artificial landmarks assistance. It provides improvements based on the traditional ICP algorithm. The result of positioning provided by the landmarks is used as the initial iteration ICP value. The combination of the ICP algorithm and landmarks enables the positioning algorithm to maintain a certain positioning precision when landmark detection is disturbed. By comparing the proposed algorithm with the positioning scheme developed by SICK in Germany, we prove that the combination of the ICP algorithm and landmarks can effectively improve the robustness under the premise of ensuring precision.
Social Robots for Evaluating Attention State in Older Adults
Authors: Chen Yi-Chen , Yeh Su-Ling , Huang Tsung-Ren , Chang Yu-Ling , Goh Joshua O. S. , Fu Li-Chen
Published: October 2021

Sustained attention is essential for older adults to maintain an active lifestyle, and the deficiency of this function is often associated with health-related risks such as falling and frailty. The present study examined whether the well-established age-effect on reducing mind-wandering, the drift to internal thoughts that are seen to be detrimental to attentional control, could be replicated by using a robotic experimenter for older adults who are not as familiar with online technologies. A total of 28 younger and 22 older adults performed a Sustained Attention to Response Task (SART) by answering thought probes regarding their attention states and providing confidence ratings for their own task performances. The indices from the modified SART suggested a well-documented conservative response strategy endorsed by older adults, which were represented by slower responses and increased omission errors. Moreover, the slower responses and increased omissions were found to be associated with less self-reported mind-wandering, thus showing consistency with their higher subjective ratings of attentional control. Overall, this study demonstrates the potential of constructing age-related cognitive profiles with attention evaluation instruction based on a social companion robot for older adults at home.
Measurement of Water Level in Urban Streams under Bad Weather Conditions
Authors: Azevedo Joaquim Amândio , Brás João André
Published: October 2021

Flood control and water resources management require monitoring the water level in rivers and streams. Water level measurement techniques increasingly consider image processing procedures. Most of the systems use a staff gauge to support the waterline detection. However, these techniques can fail when applied to urban stream channels due to water undulation, debris on the water surface, and traces of rain captured by the camera, and other adverse effects on images can be quite dramatic on the results. The importance of considering these effects is that they are usually associated with the variation in the water level with the occurrence of rain. The technique proposed in this work uses a larger detection zone to minimize the effects that tend to obstruct the waterline. The developed system uses an infrared camera to operate during the day and night. Images acquired in different weather conditions helped to evaluate the proposed technique. The water level measurement accuracy was about 1.8 cm for images taken during the day and 2.8 cm for images taken at night. During short periods of heavy rain, the accuracy was 2.6 cm for the daytime and 3.4 cm for the nighttime. Infrared lighting can improve detection accuracy at night. The developed technique provides good accuracy under different weather conditions by combining information from various detection positions to deal with waterline detection issues.
Real-Time 2-D Lidar Odometry Based on ICP
Authors: Li Fuxing , Liu Shenglan , Zhao Xuedong , Zhang Liyan
Published: October 2021

This study presents a 2-D lidar odometry based on an ICP (iterative closest point) variant used in a simple and straightforward platform that achieves real-time and low-drift performance. With a designated multi-scale feature extraction procedure, the lidar cloud information can be utilized at multiple levels and the speed of data association can be accelerated according to the multi-scale data structure, thereby achieving robust feature extraction and fast scan-matching algorithms. First, on a large scale, the lidar point cloud data are classified according to the curvature into two parts: smooth collection and rough collection. Then, on a small scale, noise and unstable points in the smooth or rough collection are filtered, and edge points and corner points are extracted. Then, the proposed tangent-vector-pairs based on edge and corner points are applied to evaluate the rotation term, which is significant for producing a stable solution in motion estimation. We compare our performance with two excellent open-source SLAM algorithms, Cartographer and Hector SLAM, using collected and open-access datasets in structured indoor environments. The results indicate that our method can achieve better accuracy.
Biopotential Signal Monitoring Systems in Rehabilitation: A Review
Authors: Palumbo Arrigo , Vizza Patrizia , Calabrese Barbara , Ielpo Nicola
Published: October 2021

Monitoring physical activity in medical and clinical rehabilitation, in sports environments or as a wellness indicator is helpful to measure, analyze and evaluate physiological parameters involving the correct subject’s movements. Thanks to integrated circuit (IC) technologies, wearable sensors and portable devices have expanded rapidly in monitoring physical activities in sports and tele-rehabilitation. Therefore, sensors and signal acquisition devices became essential in the tele-rehabilitation path to obtain accurate and reliable information by analyzing the acquired physiological signals. In this context, this paper provides a state-of-the-art review of the recent advances in electroencephalogram (EEG), electrocardiogram (ECG) and electromyogram (EMG) signal monitoring systems and sensors that are relevant to the field of tele-rehabilitation and health monitoring. Mostly, we focused our contribution in EMG signals to highlight its importance in rehabilitation context applications. This review focuses on analyzing the implementation of sensors and biomedical applications both in literature than in commerce. Moreover, a final review discussion about the analyzed solutions is also reported at the end of this paper to highlight the advantages of physiological monitoring systems in rehabilitation and individuate future advancements in this direction. The main contributions of this paper are (i) the presentation of interesting works in the biomedical area, mainly focusing on sensors and systems for physical rehabilitation and health monitoring between 2016 and up-to-date, and (ii) the indication of the main types of commercial sensors currently being used for biomedical applications.
A 10-Year Retrospective Study of Inclusion Body Hepatitis in Meat-Type Chickens in Spain (2011–2021)
Authors: Bertran Kateri , Blanco Angela , Antilles Noelia , Nofrarías Miquel , Valle Rosa M. , Cobos Àlex , Ramis Antonio , Biarnés Mar , Majó Natàlia
Published: October 2021

A surge in fowl adenovirus (FAdV) causing inclusion body hepatitis (IBH) outbreaks has occurred in several countries in the last two decades. In Spain, a sharp increase in case numbers in broilers and broiler breeder pullets arose since 2011, which prompted the vaccination of breeders in some regions. Our retrospective study of IBH cases in Spain from 2011 to 2021 revealed that most cases were reported in broilers (92.21%) and were caused by serotypes FAdV-8b and -11, while cases in broiler breeder pullets were caused by serotypes FAdV-2, -11, and -8b. Vertical transmission was the main route of infection, although horizontal transmission likely happened in some broiler cases. Despite the inconsistent and heterogeneous use of vaccines among regions and over time, the number of cases mirrored the use of vaccines in the country. While IBH outbreaks were recorded year-long, significantly more cases occurred during the cooler and rainier months. The geographic distribution suggested a widespread incidence of IBH and revealed the importance of a highly integrated system. Our findings contribute to a better understanding of FAdV infection dynamics under field conditions and reiterate the importance of surveillance, serological monitoring of breeders, and vaccination of breeders against circulating serotypes to protect progenies.
Disinfection Kinetics of Free Chlorine, Monochloramines and Chlorine Dioxide on Ammonia-Oxidizing Bacterium Inactivation in Drinking Water
Authors: Zhang Yongji , Qiu Jie , Xu Xianfang , Zhou Lingling
Published: October 2021

With the widespread use of chloramines disinfection, nitrification has become a problem that cannot be ignored. In order to control nitrification in the drinking water distribution system (DWDS), the inactivation effect of free chlorine, monochloramine and chlorine dioxide on ammonia-oxidizing bacterium (AOB) was studied under different temperature (8 °C, 26 °C and 35 °C) and pH (6.0, 7.0 and 8.7) conditions. The inactivation effect of Nitrosomonas europaea (a kind of AOB) by the three disinfectants increases with increasing temperature. As for the raised pH, the inactivation effect of free chlorine and monochloramine on AOB decreased, while that of chlorine dioxide increased. Last, but certainly not least, the experimental data of the disinfection were calculated to develop the N. europaea inactivation kinetic model, which was based on the first order Chick–Watson equation. The proposed model in this study took the two variables, pH and temperature, into consideration simultaneously, which were used to evaluate the average Ct value (multiplying the concentration of the residual disinfectant by the time of contact with N. europaea) required for different disinfectants when they produced the ideal inactivation effect on N. europaea.