bluuebunny/crossref_metadata_2025 huggingface dataset:
The practice of judicial protection of environmental rights in Ukraine: problems and prospects
Authors: Mykytiuk Anton
Published: October 2024

The scientific article is devoted to the study of the practical experience of judicial protection of environmental rights. The article defines the main concepts in the field of protection of environmental rights of citizens: “ecological rights”, “judicial protection”, “ecological policy”, “judicial protection of environmental rights” and other concepts in the context of the conceptual and categorical apparatus of the subject of research. The scientific article contains an analysis of the norms enshrined in the current legislation of Ukraine regarding the judicial protection of environmental rights of communities and the separate protection of environmental rights of citizens. The peculiarities of the practice of consideration by Ukrainian courts of cases regarding the violation of the environmental rights of citizens are given. The methodology of researching issues of environmental rights of citizens is given. The information policy of the state in the sphere of protection of environmental rights of citizens is defined. The peculiarities of the legal doctrine in the field of judicial protection of citizens’ environmental rights and the protection of citizens’ environmental rights in general are indicated, as well as the proposals of scientists in the field of law to improve the regulatory regulation of citizens’ environmental rights, as well as to improve the practice of judicial protection of citizens’ environmental rights. Peculiarities of normative and legal regulation of the sphere of judicial protection of citizens’ environmental rights have been studied. The environmental rights and obligations of individuals and legal entities in the field of protection of environmental rights are defined, and the responsibility of legal entities and individuals in terms of violation of environmental or nature protection legislation is defined. The importance of increasing the level of ensuring the realization of the environmental rights of citizens in Ukraine by implementing an effective state information policy, improving the legal regulation of ensuring judicial protection of the environmental rights of citizens, and forming an environmental policy to prevent violations of the environmental rights of citizens was emphasized.
Legal principles of pre-trial investigation war crimes
Authors: Tymoshko Volodymyr
Published: October 2024

The modern legal principles of the activity of law enforcement agencies regarding the investigation of war crimes have been defined. It is emphasized that war crimes are complex in terms of their mechanism of commission, which is characterized by consequences in the form of significant destruction of civilian infrastructure objects, a large number of unidentified dead; instruments of commission, which neither pre-trial investigation bodies nor forensic experts have encountered before; by persons of criminals who change their locations, including those who are in the territory of another state, etc. It is noted that in Ukraine since the declaration of the legal regime of martial law by the Decree of the President of Ukraine, significant changes have taken place in the criminal procedural legislation, which established a special regime of pre-trial investigation and trial under martial law conditions, provided for in Section IX-1 of the Criminal Procedure Code of Ukraine.
It is noted that the pre-trial investigation of war crimes requires considerable expenditure of resources, including human resources, due to which employees of various law enforcement agencies, including units of the National Police, are involved in carrying out certain procedural actions. Legal problems in the activities of the National Police of Ukraine regarding the organizational features of the pre-trial investigation that need to be resolved at the legislative and departmental levels are highlighted. Proposals are made to improve the legislation on the regulation of the term “war crime” in the Criminal Code of Ukraine. The requirements regarding the procedure for collecting evidence of war crimes for the purpose of further transfer of materials for consideration by the International Criminal Court have been updated. Attention is focused on the fact that the principles, subjects and forms of interaction at the national and international levels during the pre-trial investigation of war crimes should be properly regulated. During the writing of the article, the methods of dialectics, comparative legal and systemic analysis, and formal logic were used.
Conceptual Designing of a Pneumatic Warm-box System of Airship for Martian Exploration
Authors: Patel A.V. , Shah N. J.
Published: October 2024

The exploration of Mars presents significant challenges due to its harsh and unforgiving environmental conditions, particularly in relation to the thermal management of onboard systems in exploration vehicles such as airships. The planet's thin atmosphere and extreme temperatures necessitate innovative and robust solutions to ensure the success of exploration missions. This research paper explores the conceptual design of a pneumatic warm-box system, specifically tailored for use in a Martian airship. The warm-box system is crucial for maintaining the internal environment of the airship, ensuring that critical components, such as electronic systems and batteries, operate within their optimal temperature ranges. Failure to manage these temperatures effectively could lead to system malfunctions or mission failures. By applying principles from thermal insulation, advanced material science, and aerospace engineering, this study proposes a design that effectively maintains the airship's internal temperatures against the severe cold of the Martian atmosphere, ensuring sustained functionality and operational success in this extreme environment.
ANALYSIS OF EDUCATIONAL VALUES ABOUT THE POSITION OF WOMEN IN ISLAM IN THE NOVEL ‘RATU YANG BERSUJUD’ BY MAHDAVI
Authors: Ernawati Euis , Maharani Putri
Published: October 2024

Penelitian ini bertujuan untuk mengetahui bagaimana nilai-nilai pendidikan mengenai kedudukan perempuan dalam Islam menurut Al-Qur'an dan Hadist yang terdapat dalam novel Ratu Yang Bersujud karya Mahdavi. Rumusan masalah dalam penelitian ini adalah 1) Bagaimana nilai-nilai pendidikan mengenai kedudukan perempuan dalam Islam menurut Al-Qur'an dan Hadist dalam novel Ratu Yang Bersujud karya Mahdavi. Metode penelitian yang digunakan dalam penelitian ini adalah deskriptif kualitatif dengan menganalisis isi, dengan alat pengumpulan data yaitu penelitian kepustakaan.
Hasil penelitian dapat diketahui bahwa kedudukan perempuan dalam Islam yang dibahas dalam novel adalah; (1) Perempuan sebagai Manusia dan Hamba Tuhan. Terdapat 3 surat yang terdapat dalam novel tersebut, yaitu At Taubah: 17, Al Muminun 12-14, dan Al Hujurat ayat: 13 (2) Perempuan dalam Perlindungan Islam. Terdapat 6 surat yang terdapat dalam novel, Al Ahjab 59, An Nissa: 19, An Nissa: 3, At Talaaq 6, Al Baqarah 223. (3) Perempuan sebagai Subyek Hukum. Terdapat 1 surat yang terdapat dalam novel yaitu surat Al Mumtahanah : 12 (4) Wanita Sebagai Inspirasi Kekuatan Iman dan Akhlak, terdapat 1 surat yang terdapat dalam novel yaitu At Tahrim 11-12.
Introduction to Statistics with R
Authors:   Centre for Applied Statistics Courses (CASC)
Published: October 2024

The 'Introduction to Statistics with R' workshop, offered in partnership with UCL, is a five-day event designed to equip researchers from various fields with the skills to perform statistical analyses and program using R. Participants will gain a comprehensive understanding of R, covering topics from data manipulation and visualization to advanced statistical techniques, enhancing their research capabilities and enabling them to conduct more robust and reliable analyses.
Presenting a Structural Model of Factors Affecting Female Students' Adaptation to the School Environment and Comparing It with the Male Model
Authors: Mohammadjani Farzad , Ahmadi Gharacheh Ali mohammad
Published: October 2024

The present study aimed, on one hand, to propose a model of factors influencing students' adaptation to the school environment and, on the other hand, to compare this model between male and female students. The research method was correlational, and the statistical population consisted of all second-year high school students in Darab city. The research sample was selected using the Morgan Sampling Table and the proportional stratified sampling method. To measure students' adaptation to the school environment, Baker and Siryk’s (1989) School Adaptation Questionnaire, Miller and Brown’s (1999) Self-Regulation Strategies Scale, and Midgley et al.’s (1998) Goal Orientation Questionnaire were used. The data were analyzed using structural equation modeling and independent samples t-test. The results show that the direct effect of goal orientation (β = 0.372) and self-regulation strategies (β = 0.323) on female students' adaptation to the school environment was significant at the level of p = 0.01, and the direct effect of goal orientation on self-regulation strategies (β = 0.547) was statistically significant. The results of the independent samples t-test showed a significant difference between students' gender and the overall score of the School Adaptation Questionnaire (T = 2.203). Additionally, the mean adaptation score of female students to the school environment (M = 107.23) was significantly higher than that of male students (M = 96.14). Goal orientation and self-regulation strategies had a positive and significant impact on students' adaptation to the school environment. In the social adaptation component, male students demonstrated better social and interpersonal skills compared to female students, whereas female students exhibited better academic adaptation than males. Furthermore, in self-regulation strategy components such as acceptance and implementation, male students performed better than females, but in the planning component, females outperformed males.
Advances in glial cell line-derived neurotrophic factor
Authors: Yang Jin
Published: October 2024

Glial cell line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor with significant research value due to its profound effects on dopaminergic, cholinergic, and motor neurons. Initially identified for its neuroprotective role in dopaminergic neurons, GDNF has been found to support various neuronal populations and plays a crucial role in neural development, maintenance, and repair. This review provides a comprehensive overview of the molecular characteristics, tissue distribution, physiological function of GDNF and its protective effect on a series of diseases, emphasizing its potential therapeutic applications. Meanwhile, this study discusses the challenges in delivering GDNF across the blood-brain barrier and explores current strategies to enhance its clinical efficacy, including the use of gene therapy and innovative delivery methods. In summary, the review underscores the promise of GDNF as a therapeutic agent for neurodegenerative diseases and nerve injuries, highlighting the need for further research to translate these findings into clinical practice.
Effect of Management Development Programmes on Employee Performance in Federal Administrative Staff College of Nigeria (FASCON)
Authors: Ochala Mark
Published: October 2024

This study investigates the effect of management development programmes on employee performance in the Federal Administrative Staff College of Nigeria (FASCON). The research design adopted was a descriptive survey, allowing for the collection of both quantitative and qualitative data. The population of the study included all employees of FASCON, with a sample size drawn from various departments using stratified random sampling techniques to ensure representative coverage. Primary data was collected through structured questionnaires and interviews, while secondary data was obtained from relevant academic journals, reports, and organizational records. The findings reveal that Management Development Programs have significant Positive impact on Employee Performance in Federal Administrative Staff College of Nigeria. It also revealed that Workplace Rotation Programs have a significant positive impact on Skill Development in Federal Administrative Staff College of Nigeria. The study concludes that management development programs are essential for enhancing employee performance at the Federal Administrative Staff College of Nigeria. The relationship between workplace rotation programs and skill development emphasizes the importance of cross-functional training in the Federal Administrative Staff College of Nigeria. The study recommends that the Federal Administrative Staff College of Nigeria should regularly assess employee training needs and tailor management development programs to address these areas and incorporate both soft and hard skills into the development programs, ensuring a holistic improvement in performance. Federal Administrative Staff College of Nigeria should evaluate the impact of these programs through performance appraisals and employee feedback to ensure continuous improvement. The institution should implement well-structured rotation programs that allow employees to spend adequate time in different roles to build competencies effectively.
AI-Enhanced Bionics: Bridging Prosthetic Innovation and Viral Detection in the Future of Healthcare
Authors: Krishna Pasupuleti Murali
Published: October 2024

Abstract: The chapter "AI-Enhanced Bionics: Bridging Prosthetic Innovation and Viral Detection in the Future of Healthcare" explores the transformative role of artificial intelligence (AI) in revolutionizing both prosthetic technologies and viral detection systems. It begins by examining how AI-driven bionics have significantly improved the functionality, adaptability, and responsiveness of prosthetic devices, enhancing mobility and sensory feedback through advanced neural interfaces and machine learning algorithms. The chapter also delves into AI’s pivotal role in public health, focusing on viral detection technologies that monitor, predict, and mitigate outbreaks by analyzing real-time data from various sources. It highlights shared AI technologies that integrate healthcare monitoring with prosthetic innovations, offering future possibilities where AI-powered bionics serve not only rehabilitation purposes but also continuous health surveillance. The chapter concludes with an analysis of ethical considerations, such as accessibility, privacy, and regulatory challenges, and provides insight into the future of AI-enhanced healthcare, where fully integrated systems improve patient care, health outcomes, and global public health preparedness. Keywords: AI-enhanced bionics, prosthetic innovation, viral detection, healthcare monitoring, neural interfaces, machine learning, public health, viral surveillance, real-time data analysis, personalized healthcare, bio-integrated robotics, AI in healthcare, health surveillance, ethical AI, regulatory challenges.
Malignant Otitis Externa: A persistent challenge
Authors: Khribi Mayssa , El Abed Wed , Gnaba Khalil
Published: October 2024

Introduction: Although rare, Malignant otitis externa is responsible for a high morbidity and could sometimes be fatal. The management of this condition is still challenging.
 
Aim: To analyse the clinical, microbiological and radiological profile of malignant otitis externa, and the management of this condition.
 
Methods: A descriptive, cross-sectional study was conducted at ENT Department of Kairouan's hospital including 38 patients hospitalised and treated for malignant otitis externa from January 2013 to August 2021.
 
Results: The mean age of patients was 67.7 ± 12.9 years (35-98). All patients presented with continuous otalgia that resists to usual analgesics. Otorrhea was noticed in 76.3% of cases, facial palsy in 2 cases (5.3%) and dysphonia in one case (2.6%). Pseudomonas Aeruginosa was the main responsible pathogen (42%). Concomitant bacterial and fungal infection was noticed in 6.4% of the cases. First-line intravenous antibiotherapy used was mainly based on an association of Cephalosporins and Fluoroquinolones. Complete remission was noticed in 30 patients (79%). However, 8 cases of recurrences (21%) and 2 cases of deaths (5.2%) were noticed in our series. The mean follow-up was 4.6±6.3 (1-26 months).
Conclusions: Pseudomonas Aeruginosa remains the main responsible pathogen for malignant otitis externa. Nevertheless, fungal infections are rising because of the overuse of antibiotics. Antibiotherapy should be adapted to culture results and resistance profile of pathogens in hospital. Practionners should be aware of the possibility of concomitant fungal infection, especially in the case of unfavorable evolution
Sarcopenia prevalence and risk factors in obese Tunisian adults
Authors: Berriche Olfa , Rachdi Rim , Ammar Chaima , Ben Othman Rym , Gamoudi Amel , Jamoussi Henda
Published: October 2024

Introduction: Sarcopenia is a clinical condition defined as low skeletal muscle mass and function. It has been identified and described as a geriatric syndrome, but it may arise in individuals with obesity at any age.
Aim: screen for sarcopenia in obese adults and identify the nutritional, clinical and biological risk factors associated with the development of sarcopenic obesity (SO+).
Methods : Descriptive cross-sectional study, including 53 obese patients. Screening for sarcopenia has been established according to pathological thresholds proposed by the European Society for Clinical Nutrition and Metabolism (ESPEN) and the European Association for the Study of Obesity (EASO).
Results: Mean age was 44.34±13.51 years. Prevalence of Sarcopenia was 7.5% (SO+). The average intakes of calorie, lipids and saturated fatty acids were higher in SO+. A statistically significant relationship was found between low skeletal muscle mass (SMM/W) and the average intake of vitamin PP (p=0.014) and vitamin B9 (p=0.009). Mean BMI (45.86 kg/m² for SO+ versus 39.29 kg/m² for SO-; p=0.03) and mean visceral fat (16.55 l for SO+, versus 10.93 l for SO-; p=0.043) were significantly higher in SO+. A statistically significant relationship was found between insulin resistance and low (SMM/W), as attested by mean insulinemia (28.81 µIU/mL for low SMM/W, versus 14.48 µIU/mL for normal SMM/W; p=0.004) and HOMA index (7.94 for low SMM/W, versus 3.49 for normal SMM/W; p=0.002), which were higher in cases of low (SMM/W).
Conclusion: We recommend promoting a balanced, low-energy-density diet to improve insulin sensibility and thus reduce ...(abstract truncated at 250 words)
L’utilité du facteur d’épissage SRSF1 dans le grading des tumeurs gliales: Une méta-analyse
Authors: Mlika Mona , Zorgati Mohamed Majdi , Makhlouf Aymen , Mezni Faouzi
Published: October 2024

Introduction: Le grading des tumeurs gliales est basé sur des critères morphologiques et parfois moléculaires. De nombreux marqueurs ont été évalués afin de grader les tumeurs gliales sans réel consensus. Certains auteurs ont rapporté que le SRSF1, en tant que facteur d’épissage, présente une expression corrélée aux grades tumoraux.
Objectif: Dans cette étude, nous avons cherché à évaluer l’utilité de SRSF1 dans le grading des gliomes en fonction de son expression en immunohistochimie.
Méthodes: Les auteurs ont réalisé une méta-analyse selon les recommandations PRISMA sur une période de 10 ans (2013-2023). Le logiciel Meta-Disc 5.4 (version libre) a été utilisé. Les tests statistiques Q et I2 ont été utilisés pour explorer l’hétérogénéité des études. Une méta-régression a été réalisée en cas d’hétérogénéité significative. Le biais de publication a été évalué à l’aide du test Funnel Plot et du test de Egger (version gratuite JASP).
Résultats: Selon les critères d’inclusion, 4 articles ont été inclus parmi 193 articles. La SEN, la SPE et le DOR combinés représentaient respectivement 0,592, 0,565 et 1,852. L’aire sous la courbe a été estimée à 0,558, ce qui suggère une mauvaise précision diagnostique. L’hétérogénéité des SEN et SPE pondérées était statistiquement significative. L’analyse par méta-régression axée sur la technique utilisée, les clones, la dilution des anticorps primaires et la technique d’interprétation n’a révélé aucune covariable (p>0,05).
Conclusion: Même si cette méta-analyse a mis en évidence l’absence d’une véritable utilité diagnostique du SRSF1 dans le grading des tumeurs gliales, l’hétérogénéité mise en évidence renforce le besoin d’études prospectives réalisées selon les critères de qualité pour les tests diagnostiques.
Birth defects and epidemiological factors in Tunisia
Authors: Nasri Kaouther , Ben  Jemaa Nadia , Chorfi Belhassen , Sahraoui Mariem , Masmoudi Aida , Siala Gaigi Soumeya
Published: October 2024

Aim: To identify the birth defects listed in the embryo-fetopathology department of the maternity and neonatology center of Tunis (Tunisia), and to study the epidemiological factors.
Methods: We carried out a retrospective study on 2489 malformed cases including fetuses, stillborns and deceased newborns among 5750 ones autopsied in the embryo-fetopathology department of the maternity and neonatology center of Tunis.
Results: The sex ratio of autopsied cases was 1.06. 41% of them weighed less than 500 grams. The gestational age was between 22-28 weeks of amenorrhea in 41.3% of cases.
Among the maternal characteristics, we noted an average maternal age of 30.1 years old (with extremes ranging from 16 to 51 years old), and a predominance of O blood group. Parental consanguinity and history of reproductive failure were found respectively in 37.4% and 32.5% of cases.
Antenatal diagnosis was established in 62% of cases. It was positive in 59.5% of cases (all types of malformations combined).
Among the 2489 malformed cases, 4568 birth defects were identified. Neurological anomalies were the most common (26.01%) followed by nephro-urological anomalies (13.16%) and cardiovascular anomalies (11.47%).
During the study period, 164 cases of polymalformative syndromes were counted and 217 cases of chromosomal aberrations were classified.
Conclusion: This study allowed us to assess the frequency of birth defects, categorize them based on their type and determine the different epidemiological factors during a long period of nine years...(abstract truncated at 250 words).
Position statement of the Brazilian Palliative Care Academy on withdrawing and withholding life-sustaining interventions in the context of palliative care
Authors: Vidal Edison Iglesias de Oliveira , Ribeiro Sabrina Correa da Costa , Kovacs Maria Júlia , Máximo da Silva Luciano , Sacardo Daniele Pompei , Iglesias Simone Brasil de Oliveira , Silva Josimário João da , Neves Cinara Carneiro , Ribeiro Diego Lima , Lopes Fernanda Gomes
Published: October 2024

ABSTRACT The issue of withrawing and withholding life-sustaining interventions is an important source of controversy among healthcare professionals caring for patients with serious illnesses. Misguided decisions, both in terms of the introduction/maintenance and the withdrawal/withholding of these measures, represent a source of avoidable suffering for patients, their loved ones, and healthcare professionals. This document represents the position statement of the Bioethics Committee of the Brazilian Palliative Care Academy on this issue and establishes seven principles to guide, from a bioethical perspective, the approach to situations related to this topic in the context of palliative care in Brazil. The position statement establishes the equivalence between the withdrawal and withholding of life-sustaining interventions and the inadequacy related to initiating or maintaining such measures in contexts where they are in disagreement with the values and care goals defined together with patients and their families. Additionally, the position statement distinguishes strictly futile treatments from potentially inappropriate treatments and elucidates their critical implications for the appropriateness of the medical decision-making process in this context. Finally, we address the issue of conscientious objection and its limits, determine that the ethical commitment to the relief of suffering should not be influenced by the decision to employ or not employ life-sustaining interventions and warn against the use of language that causes patients/families to believe that only one of the available options related to the use or nonuse of these interventions will enable the relief of suffering.
Associação entre concentração de cortisol capilar e sintomas de estresse agudo em familiares de pacientes graves: um estudo transversal
Authors: Eugênio Cláudia Severgnini , Viola Thiago Wendt , Lumertz Francisco Sindermann , Daltrozo Adriana Valéria Hoffmeister , Saraiva Maria Eduarda Ramos , Casagrande Júlia Borges , Zanin Rafael Fernandes , Boniatti Márcio Manozzo
Published: October 2024

RESUMO Objetivo: Este estudo pretendeu investigar se existe uma associação entre concentrações de cortisol capilar e sintomas de estresse agudo em familiares de pacientes graves. Métodos: Trata-se de estudo transversal realizado em uma unidade de terapia intensiva de adultos de um hospital terciário em Porto Alegre (RS), de agosto de 2021 a fevereiro de 2022. Os familiares de pacientes internados em uma unidade de terapia intensiva por mais de 10 dias foram abordados para inscrição. Coletamos dados sociodemográficos e avaliamos a resiliência, a religiosidade e os sintomas de estresse agudo entre os familiares. Coletaram-se amostras de cabelo dos familiares logo após a entrevista para medir a concentração de cortisol capilar. Resultados: O estudo incluiu 110 familiares. Foram identificados sintomas de estresse agudo em 88 (80,0%) familiares. A mediana da concentração de cortisol capilar foi de 2,37pg/mg (1,16 - 5,06pg/mg). Não houve diferença significativa na concentração de cortisol capilar entre os familiares com e sem sintomas de estresse agudo (p = 0,419). De acordo com a análise multivariada, apenas o fato de o paciente estar alerta no momento da entrevista do familiar foi significativamente associado à prevalência de sintomas de estresse agudo no familiar. Conclusão: Não encontramos uma associação entre a concentração de cortisol capilar dos familiares em segmentos de cabelo nos meses anteriores à admissão na unidade de terapia intensiva e a ocorrência de sintomas de estresse agudo.
Advancing insights in critical COVID-19: unraveling lymphopenia through propensity score matching - Findings from the Multicenter LYMPH-COVID Study
Authors: Cidade José Pedro , Souza-Dantas Vicente Cês , Mamfrim Rafaela Braga , Miranda Renata Carnevale , Caroli Henrique Tommasi , Oliveira Natália Almeida , Thompson Alessandra e Figueiredo , Oliveira Gabriela E. , Póvoa Pedro
Published: October 2024

ABSTRACT Objective To elucidate the impact of lymphopenia on critical COVID-19 patient outcomes. Methods We conducted a multicenter prospective cohort study across five hospitals in Portugal and Brazil from 2020 to 2021. The study included adult patients admitted to the intensive care unit with SARS-CoV-2 pneumonia. Patients were categorized into two groups based on their lymphocyte counts within 48 hours of intensive care unit admission: the Lymphopenia Group (lymphocyte serum count < 1 × 109/L) and the Nonlymphopenia Group. Multivariate logistic regression, propensity score matching, Kaplan‒Meier survival curve analysis and Cox proportional hazards regression analysis were used. Results A total of 912 patients were enrolled, with 191 (20.9%) in the Nonlymphopenia Group and 721 (79.1%) in the Lymphopenia Group. Lymphopenia patients displayed significantly elevated disease severity indices, including Sequential Organ Failure Assessment and Simplified Acute Physiology Score 3 scores, at intensive care unit admission (p = 0.001 and p < 0.001, respectively). Additionally, they presented heightened requirements for vasopressor support (p = 0.045) and prolonged intensive care unit and in-hospital stays (both p < 0.001). Multivariate logistic regression analysis after propensity score matching revealed a significant contribution of lymphopenia to mortality, with an odds ratio of 1,621 (95%CI: 1,275 - 2,048; p < 0.001). Interaction models revealed an increase of 8% in mortality for each decade of longevity in patients with concomitant lymphopenia. In the subanalysis utilizing three-group stratification, the Severe Lymphopenia Group had the highest mortality rate, not only in direct comparisons but also in Kaplan‒Meier survival analysis (log-rank test p = 0.0048). Conclusion Lymphopenia in COVID-19 patients is associated with increased disease severity and an increased risk of mortality, underscoring the need for prompt support for critically ill high-risk patients. These findings offer important insights into improving patient care strategies for COVID-19 patients.
KINERJA PERANGKAT DESA DALAM PENYELENGGARAAN PELAYANAN PUBLIK DI KANTOR DESA PARIJATAH KULON KECAMATAN SRONO KABUPATEN BANYUWANGI
Authors: Oktaviyani Bella , Wilujeng Sri , Imaniar Dimas
Published: October 2024

The Performance Of Village Office In The Implementation Of Public Service In Village Office Of Parijatah Kulon Village, Srono District, Banyuwangi Regency. Along with the times, society demands high value public sercices from the government, even though these demands are repeteadly not in line with expectations, because public services have so far been less professional. To improve of service, a performance at the village office cannot work without a village apparture. This improvement in the quality of performance village apparature to save time in fulfilling the functions of village officials and aims to improve the work discipline of an employee works, so that the result obtined are in accordace with thw services ecpected by the community. The research method used in thid study is a qualitative approach, where the research is descriptive in nature which describe the phenomena in the field being studied. For data collection techniques is Observation, Interview, Documentation, and Triangulation. The use of this qualitative method aims to obtain in depth information about the performance of the Parijatah Kulon Village Apparature in the implementation of public services. The performance of this village apparature as invetigated using T.R Mitchell’s theory which has five aspects is quality, promptness, initiative, capability, and communication.
Barriers to Law Enforcement Responsive to the Interests of Victims: A Study on the Practice of Justice for Violent Crimes in the Jurisdiction of Class IA Kupang District Court
Authors: Fallo Debby F Ng , Amalo Heryanto , Dima Adrianus Djara
Published: October 2024

Objectives: The aim is to identify the barriers to the enforcement of laws against violent crimes that are responsive to the interests of victims of violent crimes. Methods: This research method falls within the specification of empirical legal research/sociological-juridical studies because it is viewed from the perspective of the legal function to protect societal interests. For primary data collection, field research (field interview) was conducted, using a questionnaire as an interview guide, and document study was carried out using a document form as a tool. The collected data were processed procedurally following the processing steps: editing, coding, and tabulation. They were then analyzed qualitatively and further elaborated descriptively. Results: The research results have identified the barriers to the enforcement of laws that are responsive to the interests of victims of violent crimes: the factor of criminal sanctions for violent crimes that do not accommodate the interests of victims of violence; the factor of victims' inability to participate in claiming compensation; the factor of law enforcement bias towards legal certainty aspects, disregarding actions for victim recovery; and the factor of the defendant's economic incapacity to compensate the victim.
A COMPREHENSIVE ANALYSIS OF ARCHITECTURAL PATTERNS IN ASP.NET CORE WEB APPLICATION DEVELOPMENT
Authors: MUSHICA Florinë , MEMETI Agon
Published: October 2024

The landscape of web application development has undergone significant transformations since the inception of the World Wide Web. In the contemporary landscape of web development, a multitude of design patterns, frameworks, and programming languages are employed to construct web applications, adapting to their diverse levels of complexity. Model-View-Controller (MVC) stands out as a widely embraced design pattern in the construction of web applications. This paper's primary goal is to provide a comprehensive elucidation of the features and fundamental components intrinsic to the MVC architectural pattern. Through practical examples and in-depth analysis, readers will gain valuable insights into the nuances of MVC, empowering them to harness its capabilities for robust and effective web application development.
DESIGNING USE CASE DIAGRAMS AND SCENARIOS FOR CREATING THE BLOCKCHAIN SYSTEM FOR BIG DATA MANAGEMENT
Authors: REXHEPI Hakan , RUSTEMI Avni , ILAZI Sazana , IDRIZI Florim , AJVAZI Grela , IDRIZI Hirijet
Published: October 2024

Smart contracts programming plays an important role nowadays in creating blockchain systems. Blockchain technology is one of the technologies that offer hope for overcoming problems related to the preservation of identity, privacy, transparency, and, above all, the immutability of data. The creation of blockchain systems is a challenge that researchers are facing, especially with big data management, due to the high maintenance costs. Currently, however, blockchain technology is finding a lot of use when combined with centralized databases, effectively replicating a blockchain database and network. Through the paper, we will try to clarify the main challenges in blockchain programming, and the reasons for not implementing blockchain programming for big data management. We will present examples of smart contract programming in the Solidity programming language, and we will make analyses and comparisons with centralized object-oriented systems. Part of the work will also be the design of use case diagrams and scenarios for the implementation of blockchain systems in big data management. The main purpose of this paper is to arouse some interest among young developers, to deal with programming in Solidity and the creation of blockchain systems for big data management.
Harmonization of The Role of Religious and State Justice Institutions in Handling Victims of Domestic Violence
Authors: Ismiati Saptosih , Widjanarto Haswar , Wafa Azizah Ersya Aqila
Published: October 2024

Domestic abuse is a subject of public law, thereby transcending the private sphere of the marital relationship and necessitating official intervention in its resolution. Domestic violence falls under criminal law, although divorce pertains to civil family law, resulting in two distinct legal processes in the divorce settlement that follow incidents of domestic abuse. Law Number 23 of 2004 addresses the Elimination of Domestic Violence, serving as the inaugural legislative framework that explicitly safeguards victims of domestic violence offenses. This study employs a descriptive-analytical research methodology. This study employs a normative juridical approach, utilizing literature and secondary data as the foundation for research, which involves an examination of relevant laws, regulations, and literature pertinent to the research process. Simultaneously, the analysis employed in this study methodology is qualitative legal.  This study concluded that the Religious Court lacks the authority to adjudicate domestic violence cases, as it does not possess jurisdiction over public law matters. In addressing community needs, the majority of domestic violence cases are promptly adjudicated for divorce in the Religious Court without prior resolution in the District Court. Consequently, harmonization between the Religious Court and the District Court is necessary for the resolution and adjudication of divorce cases involving domestic abuse. Immediate formulation of clear and tangible regulations is necessary to address divorce cases stemming from domestic abuse, namely by granting the Religious Court the competence to adjudicate matters pertaining to public law, particularly those involving domestic violence.
A Comparative Analysis of Generic Drug Assessment and Regulatory Approval in the USA, Europe and India
Authors:   Department of Pharmaceutical Chemistry & Quality Assurance, School of Pharmacy, Rai University, Saroda, Dholka Road, Ahmedabad, Gujarat, INDIA-382260, Patel Bhoomi D. , Suthar Shailesh P. ,   School of Pharmacy, Rai University, Saroda, Dholka Road, Ahmedabad, Gujarat, INDIA-382260, Mansuri Arman M ,   School of Pharmacy, Rai University, Saroda, Dholka Road, Ahmedabad, Gujarat, INDIA-382260, Joshi Vishvash D. ,   School of Pharmacy, Rai University, Saroda, Dholka Road, Ahmedabad, Gujarat, INDIA-382260
Published: October 2024

The Abbreviated New Drug Application (ANDA) is used for the regulatory submission of generic drugs, which are pharmaceutical equivalents to brand-name drugs and distributed without patent protection. Different countries have their own regulatory requirements for the approval of generic drugs, enforced by authorities such as the CDSCO in India, EDQM in Europe, and USFDA in the United States. This review aims to compare the regulatory processes and requirements for generic drug approval in India, Europe, and the US, highlighting key differences and challenges. The involvement of regulatory authorities in the drug development process is crucial for expediting approval and addressing queries, helping to minimize delays. The Common Technical Document (CTD) format is employed across regions to harmonize submission requirements. This study underscores the differences in dossier submission for generics across the three regions, illustrating India’s position in the global generic drug approval landscape. By comparing approval requirements, this work provides insight into the hurdles India must overcome to streamline its approval process. The ANDA allows generic manufacturers to submit bioequivalence studies, using the original innovator’s safety and efficacy data. However, obtaining approval simultaneously from multiple regulatory authorities remains a challenging task. Careful review of regulatory documents by skilled personnel can reduce regulatory queries, ultimately accelerating the market launch of generic drugs. This review provides a comprehensive overview of the generic drug approval process, emphasizing the need for harmonization and improved efficiency in India’s regulatory framework.
Las nuevas tecnologías como herramienta para la búsqueda de empleo
Authors: Chávez Cárdenas Raúl Alberto
Published: October 2024

En esta nueva época la tecnología ha tomado demasiada relevancia en la vida cotidiana, se usa para la comunicación, entretenimiento y hasta para encontrar empleo, aun así, la búsqueda de este es cada vez más competitiva y difícil, sobre todo si quien la realiza es un joven universitario sin experiencia alguna, debido a esto los jóvenes universitarios deben prepararse de la mejor manera. De la misma manera que empresas y reclutadores procuran crear una reputación digital y una imagen de marca, los candidatos también tienen que crear una estrategia 2.0 basada en crear, compartir y conversar. Se trata de hacerse visibles para que las oportunidades los encuentren. Las empresas cada vez más están utilizando las nuevas tecnologías como una herramienta de reclutamiento, esta nueva forma es denominado reclutamiento 2.0, como opina Adecco sobre Redes Sociales y Mercado de trabajo, la relevancia que en la actualidad la web 2.0 tiene a la hora de encontrar empleo ha crecido exponencialmente.
ПСИХОЛИНГВИСТИЧЕСКИЕ ИССЛЕДОВАНИЯ В РОССИИ: ИСТОРИЯ, ПРОБЛЕМЫ, МЕТОДЫ, ШКОЛЫ. ЧАСТЬ 1. ГЕНЕЗИС ОТЕЧЕСТВЕННОЙ ПСИХОЛИНГВИСТИКИ
Authors: Закраилова Б.Р.
Published: October 2024

Настоящая статья является первой в цикле обзорных статей, посвященных истории становления и развития отечественной психолингвистики. В статье обозначены основные события и приведены исторические факты, отражающие формирование проблемного поля психолингвистики, ее терминологического аппарата, методологии и первой школы – Московской психолингвистической школы, у истоков которой стоял разработчик теории речевой деятельности А.А. Леонтьев. Дана краткая характеристика теории речевой деятельности. Кроме того, в статье описана история формирования Санкт-Петербургской психолингвистической школы, а также перечислены регионы, в которых активно проводятся исследования в области психолингвистики (в частности, сказано о начале зарождения психолингвистики на Северном Кавказе).
El notariado y el cine: cómo ve el séptimo arte la figura del notario/a
Authors: Ramón Fernández Francisca
Published: October 2024

Cuando vemos la representación en el cine del notariado muchas veces se aleja de la realidad. Se tiende a mostrar a una persona de edad avanzada, preferiblemente varón (es cierto que localizar una mujer Notaria en el cine es harto difícil), poco amable, con una actitud rígida y en un despacho vetusto y poco dado a la tecnología. La modernización de la función notarial es muy complicada encontrarla en el cine, y esos ingredientes de profesión antigua, difícil y en la que la figura del notario se limita a firmar documentos, es muy lejos de la realidad actual.
Contratos de película: 10 casos prácticos de derecho de contratos basados en películas
Authors: Gálvez Criado Antonio
Published: October 2024

Índice de películas y temas jurídicos sobre contratos: Película Al diablo con el diablo: contrato atípico, validez del contrato y buena fe en el cumplimiento del contrato Película Esta casa es una ruina: compraventa de inmueble y responsabilidad por defectos ocultos Película Incógnito: compraventa de obras de arte y usos del comercio acerca de su autenticidad Película Una noche en la ópera: contrato de obra/servicios y validez de este contrato Película El pisito: arrendamiento de renta antigua y matrimonio de conveniencia Película De repente, un extraño: inquiokupación y recuperación de la posesión por el arrendador Película El mercader de Venecia: contrato de préstamo y contrato de garantía Película Chef: contrato de sociedad civil Película El último regalo: contrato de donación Película La caja de las sorpresas: contrato aleatorio (juego y apuesta)
ABORDAGEM CLÍNICO-CIRÚRGICA DE LEIOMIOSSARCOMA INTESTINAL EM CÃO: RELATO DE CASO
Authors: Soares Alexandra Woods Leite , Denevitz Rodiney Pinheiro
Published: October 2024

The work presents the case of a female dog diagnosed with an abdominal mass through total abdominal ultrasonography. The patient underwent exploratory laparotomy, where a mass in the jejunum was detected. The patient was referred for exploratory laparotomy with complete surgical resection of the tumor, showing good postoperative progress. The definitive diagnosis was obtained through histopathological and immunohistochemical examination, identifying an intestinal leiomyosarcoma.
O PAPEL DO FARMACÊUTICO NA IDENTIFICAÇÃO E PREVENÇÃO DE INTERAÇÕES MEDICAMENTOSAS
Authors:   Fabiana Sousa Pugliese, Barone Patrícia Lima , Oliveira Mariana Kaizer de , Andrade Leonardo Guimarães de ,   Sebastian Rinaldi
Published: October 2024

The study aims to analyze the role of pharmacists in identifying and preventing drug interactions, highlighting the importance of their role in promoting patient safety and treatment efficacy. The methodology used was an integrative literature review with a descriptive and qualitative approach. The research involved the analysis of scientific articles published between 2018 and 2024. The development of the article addresses the practices of pharmacists in identifying drug interactions, the use of technological tools, such as clinical decision support software, and the importance of continuing education for the prevention of interactions. The study shows that pharmacists are essential in reviewing medical prescriptions, guiding patients, collaborating with other health professionals, and ensuring comprehensive and safe care. It also highlights the impact of continuous training and the use of advanced technologies on the effectiveness of pharmaceutical practices. In conclusion, the article reaffirms the importance of the pharmacist in the health team and recommends valorizing their role through public policies that support continuing education and the integration of patient care practices, ensuring the safety of medication use and improving patients' quality of life.
ABORDAGENS CLÍNICAS PARA O FECHAMENTO DE DIASTEMA
Authors: Veloso Alice Andrade , Matos Murillo Freitas
Published: October 2024

Diastema is characterized by the absence of contact between two or more adjacent teeth. It is a condition that can be seen in any region of the oral cavity, the presence of diastemas is more related to the antero-superior region of the maxilla, due to the discrepancy between the size of the teeth and the maxillary bones. The clinical evaluation of the patient who requires treatment to close diastemas should involve inspection of the teeth, occlusion, insertion of the labial frenulum and positioning of the lips, in addition to a careful analysis of periodontal health. The etiology of diastema is multifactorial, involving genetic aspects, oral habits, size and position of teeth, as well as factors related to the growth and development of the mouth. Understanding these causes is essential for planning appropriate treatment. Therefore, the purpose of this study was to conduct a literature review on the different treatment options for diastema closure.
USO DE ANSIOLÍTICOS E ANTIDEPRESSIVOS EM ACADÊMICOS DO CURSO DE FARMÁCIA DA UNIVERSIDADE DE GURUPI – UNIRG
Authors: Paula Carlos Vinicius Lima de , Oliveira Agamenon Almeida de , Silva Kelly Mayanny Inácio , Lima Delma da Silva , silva Douglas dos Santos , Matias Talia Gonçalves Ribeiro , Diniz Daniel Carvalho , Gaudioso Kamila Gomes Costa , Figueira Hávilla Clycia Oliveira Siqueira , Campos Thales Guilherme Silva
Published: October 2024

The aim of this study was to assess the use of antidepressants and anxiolytics among pharmacy students at the University of Gurupi-UNIRG. The methodology adopted was predominantly qualitative, quantitative, and descriptive with an exploratory approach. Qualitative research sought to discuss concepts based on the analysis of empirical data, quantitative gives greater accuracy to the way a variable works and relates to others, while the descriptive nature focused on the detailed understanding of phenomena without manipulating them, aiming to identify patterns of regularity in human behavior, both individual and in groups, exploratory research aimed to provide familiarity with the object of study, being useful when a clear definition of the problem is required. It was used to obtain initial data and develop a more in-depth approach, exploring a specific situation through comprehensive methods. The investigation was conducted using the “GOOGLE FORMS” tool, aimed at pharmacy students from the first to the tenth period. The method used consisted of structured questionnaires, carefully formulated to achieve the research objectives. The study concluded that females aged between 18 and 22 are the ones who most often seek pharmacological treatment for anxiety and depression, with escitalopram being the drug most used for treatment.
ATUAÇÃO DOS PROFISSIONAIS ENFERMEIROS FRENTE À VIOLÊNCIA A MULHER
Authors: Silva Riquele Santana , Santos Tamyssa Simões dos , Soares Manoel Holanda
Published: October 2024

Introdução: A atuação do enfermeiro na atenção à mulher vítima de violência doméstica desempenha um papel crucial na identificação precoce, acolhimento e encaminhamento para serviços especializados. Por meio de uma abordagem empática e sensível, os enfermeiros criam um ambiente seguro para que as vítimas possam relatar suas experiências e buscar ajuda. Além disso, oferecem suporte emocional, orientação sobre direitos e recursos disponíveis na comunidade. No entanto, enfrentam desafios como a falta de capacitação específica, recursos limitados e protocolos claros de atendimento. Investimentos em capacitação e suporte institucional são essenciais para fortalecer a capacidade dos enfermeiros no enfrentamento dessa grave violação de direitos humanos, contribuindo para uma resposta mais eficaz e compassiva à violência contra as mulheres.