bluuebunny/crossref_metadata_2025 huggingface dataset:
A Review of the Physical and Chemical Characteristics and Energy-Recovery Potential of Municipal Solid Waste in China
Authors: Li Jinsong , An Donghai , Shi Yuetao , Bai Ruxue , Du Shanlin
Published: January 2024

The complexity and strong spatial and temporal characteristics of municipal solid waste (MSW) have made resource utilization a major challenge in establishing the life-cycle model of MSW. Based on the planning of the domestic “dual-carbon” target and the current status of the structural transformation of resource utilization, this paper summarizes the physicochemical properties of MSW in China by component, species, and region. The aim is to identify the physicochemical components of MSW in different regions of China, drawing on the research findings of various scholars. A total of 159 sets of MSW data were collected, including 90 sets of physical composition and 69 sets of elemental composition. These data were used to calculate the calorific value of MSW and determine the energy-recovery and power-generation potentials before and after MSW classification. The analysis estimates the volume of MSW requiring removal in different regions of China in 2021 and assesses the effectiveness of the energy-recovery potential (ERP) and power-generation potential (PGP) before and after MSW classification in these regions. The aim is to offer insightful guidance and recommendations for municipal waste-treatment strategies tailored to the diverse regions of China.
Integrated Waste-to-Energy Process Optimization for Municipal Solid Waste
Authors: A. Gabbar Hossam , Ahmad Muhammad Sajjad
Published: January 2024

Within the past few decades, thousands of experiments have been performed to characterize urban waste and biomass to estimate their bioenergy potential and product identification. There is a need to develop an integrated process model based on the experimental literature, as well as simulations to obtain suitable products. In this study, municipal solid waste (MSW), including paper and plastic characterization and an integrated process model, were developed to optimize the final products in a reactor system. The process model has two modes, R&D and reactor control (RC), to obtain suitable products including bio-oil, char, and gases. A database was integrated based on thermokinetics, machine learning, and simulation models to optimize product efficiency. The experimental data include those obtained by thermogravimetric analysis and Fourier-transform infrared spectroscopy, which were linked to a pyrolysis experimental setup. Feedstock product mapping models were incorporated into the database along with the temperature, heating rates, elemental analysis, and final product concentration, which were utilized for the pyrolysis reactor setup. Product feasibility was conducted based on life cycle cost, affordability, and product efficiency. The present work will bridge the gap between experimental studies and decision-making based on obtained products under several experimental conditions around the world.
Energy-Efficient Implementation of the Lattice Boltzmann Method
Authors: Vysocky Ondrej , Holzer Markus , Staffelbach Gabriel , Vavrik Radim , Riha Lubomir
Published: January 2024

Energy costs are now one of the leading criteria when procuring new computing hardware. Until recently, developers and users focused only on pure performance in terms of time-to-solution. Recent advances in energy-aware runtime systems render the optimization of both runtime and energy-to-solution possible by including hardware tuning depending on the application’s workload. This work presents the impact that energy-sensitive tuning strategies have on a state-of-the-art high-performance computing code based on the lattice Boltzmann approach called waLBerla. We evaluate both CPU-only and GPU-accelerated supercomputers. This paper demonstrates that, with little user intervention, when using the energy-efficient runtime system called MERIC, it is possible to save a significant amount of energy while maintaining performance.
Copper Speciation in Wine Growing-Drain Waters: Mobilization, Transport, and Environmental Diffusion
Authors: De Carsalade du Pont Valentin , Ben Azzouz Amani , El Hadri Hind , Chéry Philippe , Lespes Gaëtane
Published: January 2024

Copper (Cu) has been used to treat vines for a long time, which has led to its accumulation in vineyard soils. In the present work, the mobilization of copper from these soils and its transport, and diffusion outside the plots by drain water were investigated. For this, the distribution of copper between the dissolved and colloidal phases, and within the colloidal phase, of these waters was determined using an investigation strategy based on the coupling between a size separation technique, asymmetric flow field-flow fractionation, and several detectors. First, the total copper concentrations in water from different drains were monitored over a period of 2 years: Cu was mainly found in the fraction of < 450 nm. Then, the distribution of copper on the size continuum was more closely studied in water from one of the drains, sampled over a winter period. Between 45 and 75% of Cu was found in the 2–450 nm colloidal fraction. The <450 nm colloidal phase of the drain waters was found to be mainly composed of humic acids (~15 to 60 mg L−1) and clay-rich particles (~100 to 650 mg (Al) L−1). These particles also contained (hydr)oxides of iron and manganese. The concentrations of Fe and Mn were approximately 100 to 200 times lower than those of Al. The majority of humic acids had an apparent molar mass of ≤ 10 kDa. They were distributed along the size continuum: (i) in a population with an average size of ~20 nm, probably consisting of supramolecular entities, and (ii) associated with clay-rich particles with a size of ~120–200 nm. Copper was found to be complexed with humic acids and associated with clays via clay-humic complexes. Copper mobilization from the soil to the water and its transport to the drain water appeared governed by the soil humidity level and the rainfall.
Non-Conventional Yeasts from Mozzarella Cheese Whey and Artisanal Sourdoughs: Leavening Capacity and Impact on Bread Sensory Profile
Authors: Boscaino Floriana , Ionata Elena , De Caro Salvatore , Sorrentino Alida
Published: January 2024

Non-conventional yeasts (NCYs) (i.e., non-Saccharomyces) are used as alternative starters to promote aroma complexity of fermented foods (e.g., bakery products). A total of 66 yeasts isolated from artisanal food matrices (bread and pizza sourdoughs and milk whey) from different geographical areas of the Campania region (Italy) were screened for physiological and technological characteristics such as leavening ability, resistance to NaCl and pH, exopolysaccharide and phytase activity production, and carbohydrate assimilation. Selected and isolated microorganisms were also used to study the leavening kinetics in experimental doughs as mixed inocula of two different strains. Volatile organic compounds (VOCs) of the inoculated doughs were analyzed with solid-phase microextraction/gas chromatography–mass spectrometry (SPME/GC-MS). Most of the strains belonged to non-Saccharomyces species (Pichia kudriavzevii, Kluyveromyces marxianus) and Saccharomyces (S. cerevisiae). Several strains produced exopolysaccharides (EPSs), that are important for dough rheological properties. Moreover, yeasts isolated from whey showed extracellular phytase activity. The mixed starter culture of the S. cerevisiae and NCY strains showed a synergic effect that enhanced the doughs’ aroma complexity. The use of non-conventional yeasts mixed with S. cerevisiae strains can be advantageous in the bakery industry because they improve the bread aroma profiles and nutritional properties by bioactive molecule production.
Mandelbrot Set as a Particular Julia Set of Fractional Order, Equipotential Lines and External Rays of Mandelbrot and Julia Sets of Fractional Order
Authors: Danca Marius-F.
Published: January 2024

This paper deepens some results on a Mandelbrot set and Julia sets of Caputo’s fractional order. It is shown analytically and computationally that the classical Mandelbrot set of integer order is a particular case of Julia sets of Caputo-like fractional order. Additionally, the differences between the fractional-order Mandelbrot set and Julia sets from their integer-order variants are revealed. Equipotential lines and external rays of a Mandelbrot set and Julia sets of fractional order are determined.
Traditional Uses, Pharmacology and Phytochemistry of the Medicinal Plant Flueggea virosa (Roxb. ex Willd.) Royle
Authors: Bailly Christian
Published: January 2024

The white berry bush, officially Flueggea virosa (Roxb. ex Willd.) Royle is a medicinal plant distributed throughout tropical areas and traditionally used in Africa, India and China. Root decoctions are used to treat abdominal pain, whereas extracts from the aerial parts serve to treat liver and urinary diseases, inflammatory pathologies and diabetes, among other pathologies. Plant extracts have revealed antiparasitic, antimicrobial, antiepilepsy, antidiabetic, anticancer and analgesic effects. Three main categories of phytochemicals were isolated from F. virosa: polyphenols, with the lead product bergenin; terpenoids, such as the flueggenoids and related podocarpane-type diterpenoids; and many alkaloids derived from securinine and norsecurinine. A remarkable feature of S. virosa is the production of norsecurinine oligomers, including macromolecular tetramers and pentamers, such as fluevirosinines. The most potent anticancer alkaloid in the family is the dimeric indolizidine flueggine B, which was identified as a potential binder to α/β-tubulin dimer, which is a known target for securinine. This review highlights the diversity of phytochemicals identified from S. virosa and the potential therapeutic benefits of dimeric alkaloids. Studies are encouraged to further investigate the therapeutic properties of the lead compounds but also define and finesse the nutritional profile of the edible fruit.
New Developments in the Ultrasonography Diagnosis of Gallbladder Diseases
Authors: Mencarini Lara , Vestito Amanda , Zagari Rocco Maurizio , Montagnani Marco
Published: January 2024

Gallbladder diseases are very common, and their diagnosis is based on clinical–laboratory evaluation and imaging techniques. Considering the different imaging diagnostic tools, ultrasound (US) has the advantage of high accuracy combined with easy availability. Therefore, when a gallbladder disease is suspected, US can readily assist the clinician in the medical office or the emergency department. The high performance of US in the diagnosis of gallbladder diseases is mainly related to its anatomic location. The most frequent gallbladder pathological condition is gallstones disease, easily diagnosed via US examination. Acute cholecystitis (AC), a possible complication of gallstone disease, can be readily recognized due to its specific sonographic features. Additionally, a number of benign, borderline or malignant gallbladder lesions may be detected via US evaluation. The combined use of standard B-mode US and additional sonographic techniques, such as contrast-enhanced ultrasonography (CEUS), may provide a more detailed study of gallbladder lesions. Multiparametric US (combination of multiple sonographic tools) can improve the diagnostic yield during gallbladder examination.
Developing a Core Outcome Set for Cytoreductive Surgery for Colorectal Cancer with Peritoneal Metastases: A Mixed-Method Study Protocol
Authors: Raichurkar Pratik , Brown Kilian , Ansari Nabila , Koh Cherry , Ahmadi Nima , Solomon Michael , Moran Brendan , Steffens Daniel
Published: January 2024

As the number of centres offering cytoreductive surgery (CRS) for colorectal cancer with peritoneal metastases (CPMs) is increasing worldwide, research is focused on establishing better patient selection and ensuring that new techniques have positive impacts on survival. However, high-impact comparative research in this field is limited by the heterogeneity of outcome measurement and reporting. Additionally, as there are comparatively few randomised controlled trials reporting comprehensive patient-reported outcomes, it is possible that key stakeholders such as patients and carers are underrepresented in the current literature. A core outcome set (COS) for CRS with or without intraperitoneal chemotherapy for the treatment of CPMs, supported by clinicians and patients, will promote homogenous comparison across trials and optimise the utility of research findings. We have established a comprehensive protocol based on the Core Outcome Measures in Effectiveness Trials (COMETs) method to facilitate this. A systematic review will identify all the outcomes reported in the literature, whereas a semi-structured interview will identify outcomes considered important by patients and carers. The identified outcomes will populate an international Delhi survey, distributed to patients, carers, surgeons, oncologists, nurses, and allied health clinicians. Outcomes reaching international consensus of importance will be further discussed in a face-to-face workshop between patients, carers, and clinicians. This process will inform the development of a final COS for CRS for patients with CPMs.
Holocaust: Artistic Dimensions of Contemporary Ukrainian Prose (Using the Example of Larysa Denysenko’s Echoes: From the Dead Grandfather to the Deceased
Authors: Davidovitch Nitza , Gerkerova Aleksandra , Kerdivar Natalia
Published: January 2024

In recent times, global events have starkly illuminated the disturbing absence of ethnic tolerance, thrusting interethnic conflicts into the spotlight and casting shadows over both individual and collective identities. This research focuses on the Holocaust, delving into the annals of history through the lenses of recollection, personal identification, and genetic memory, as portrayed within the pages of the novel Echoes: From the Dead Grandfather to the Deceased. The primary aim is to fathom the gradual erosion of collective historical memory over time and discern its profound significance for future generations. Within this study, an examination of the interplay between the ‘collective unconscious’ and the ‘personal unconscious’ is undertaken. Additionally, the novel’s utilization of symbols and details is scrutinized. The research employs a multifaceted approach, encompassing historical-genetic, interpretative, narrative, and psychoanalytic methodologies. Through the protagonist’s transformative journey, the novel highlights the importance of preserving historical memory and recognizing its lasting impact on individual and collective consciousness.
Understanding and Awareness of Dementia in the Pakistani-Origin Community of Stoke-on-Trent, UK: A Scenario-Based Interview Study
Authors: Nazir Nargis , Kevern Peter
Published: January 2024

The aim of this project was to explore the understanding and awareness of dementia in the Pakistani-origin community in a deprived urban region of the UK. The study was unique in accessing and interviewing Pothwari speakers, some of whom could not read or understand spoken English. Data generated from an earlier study were used to construct five scenarios, which were used as the basis for face-to-face semi-structured interviews with 11 male and female participants from the Pakistani-origin community spanning two generations. Braun and Clarke’s six phases of thematic analysis were used to analyse the data to answer the research questions. Themes constructed from these interviews indicated a lack of awareness and understanding of dementia, a range of attitudes and assumptions, reluctance to seek external support, and a significant role for the cultural background in shaping the individuals’ responses. The study found that poor understanding, cultural differences, and language issues presented barriers to accessing services in the British Pakistani community, particularly among those who had been born in Pakistan and/or spoke Pothwari in preference to English. Services and information may need to be offered by Pothwari speakers in order to reach this neglected sector of the population.
A Comparative Study on the Quality of Life of Survivors of Stroke and Acute Myocardial Infarction
Authors: Lourenço Eva , Sampaio Mário Rui dos Mártires , Sánchez-Ramos José Luis , Costa Emília Isabel Martins Teixeira da
Published: January 2024

Background: Worldwide, cardiovascular diseases, particularly acute myocardial infarction and strokes, lead to significant fatalities. Survivors often experience profound impacts on various aspects of their lives, making the assessment of their Quality of Life crucial for understanding their condition and adaptation to the illness. Methods: A community-based, descriptive cross-sectional study was conducted to compare how survivors of stroke and acute myocardial infarction perceive their Quality of Life. The Portuguese version of the World Health Organization Quality of life instrument was administered to 204 acute myocardial infarction and stroke survivors. Clinical and sociodemographic variables were also compared. Results: Statistically significant differences (p < 0.05) were noted in overall, physical, and psychological aspects of Quality of Life between the two groups, with stroke survivors consistently showing lower values in these dimensions. Conclusions: The Quality-of-Life perception of stroke and acute myocardial infarction survivors may be affected by several sociodemographic and clinical factors, and the results support the idea that the vascular event conditions the person’s Quality of Life, particularly in variables related to the person’s physical condition, functionality, and autonomy.
Resilience, Satisfaction with Life and Anxiety in the Israeli Population after Mass Vaccination for COVID-19
Authors: Sarid Miriam , Tutian Rony , Kalman-Halevi Maya , Gilat-Yihyie Sharon , Sarid Adi
Published: January 2024

Objectives: The current study aimed to examine the relationships between resilience and personal characteristics such as socio-economic status, employment, satisfaction with life, and anxiety, during the period of returning to routine life after mass vaccination for COVID-19. Method: 993 Israeli participants, 52% female and 48% male, with a mean age of 40 years (18 to 89 years old) responded to an online questionnaire during March 2021. We hypothesized that (1) unemployed individuals and those with a low SES would have lower resilience, lower satisfaction with life and higher anxiety, (2) individuals who were ill with COVID-19 would have lower resilience and satisfaction with life and a higher level of anxiety, and (3) a higher resilience would be related to a lower level of anxiety. Results: The findings showed that unemployed individuals had lower levels of resilience and satisfaction with life and higher levels of anxiety than employed individuals. Specifically, those who experience a large gap between their socio-economic and employment statuses are at a greater risk than others. In addition, differences were found between people who had experienced COVID-19 illness and those who had not, but only with their satisfaction with life. People who had been ill were more satisfied than those who had not been ill. Eventually, as expected, a higher resilience was related to a lower level of anxiety, specifically at the lower levels of resilience. Conclusions: The findings of this study can provide additional perspectives on the day after a crisis (COVID-19) and the need for the development of intervention programs to strengthen the resilience of individuals who experience a gap between their SES and employment statuses when returning to their routine life after a crisis. The study also shed light on the unique correlation between anxiety and resilience, implying that following a crisis, high-resilience individuals face their anxiety better than low-resilience individuals.
Dynamic-Based Limit Analysis for Seismic Assessment of Free-Standing Walls of San Giovanni Church in Castelseprio UNESCO World Heritage Site
Authors: Sbrogiò Luca , Tavano Lorenzo , Saretta Ylenia , Caprino Amedeo , Chavarría Arnau Alejandra , Brogiolo Gian Pietro , Valluzzi Maria Rosa
Published: January 2024

Free-standing archaeological walls are significantly exposed to horizontal actions (e.g., earthquakes) as they lack connections provided by floors or roofs. In such cases, the dynamic response governs the activation of local mechanisms of collapse, determining the shape of the macroblocks and their position. Engineering models of archaeological walls are developed according to the results of extensive visual inspections and on-site testing, including modal identification for calibration purposes. A modal response spectrum analysis on the calibrated model identifies the zones where the tensile stress is exceeded, which are more likely to detach as rigid macroblocks and subsequently overturn due to the expected ground spectra. The macroblocks are then assessed according to limit analysis. The case studies are the north and the apse walls of the church of San Giovanni Evangelista in Castelseprio (Varese, Lombardy), a 5th century Longobard fortified settlement, a part of UNESCO World Heritage. The construction quality of the apse was poorer than the north wall, but the masonry of both is very compact thanks to the good mortar. The macroblocks are identified mostly in the upper crests of the walls, and their acceleration of activation is two to six times larger than the demand (considering the dynamic amplification that the structure applies to the ground motion); therefore, no particular intervention is needed. The proposed method will require additional calibration, e.g., through nonlinear dynamic analyses, and a more precise treatment of uncertainties in masonry mechanical properties to determine the shape of the macroblocks.
Genetic Cause of Hybrid Lethality Observed in Reciprocal Interspecific Crosses between Nicotiana simulans and N. tabacum
Authors: Tezuka Takahiro , Nagai Shota , Matsuo Chihiro , Okamori Toshiaki , Iizuka Takahiro , Marubashi Wataru
Published: January 2024

Hybrid lethality, a type of postzygotic reproductive isolation, is an obstacle to wide hybridization breeding. Here, we report the hybrid lethality that was observed in crosses between the cultivated tobacco, Nicotiana tabacum (section Nicotiana), and the wild tobacco species, Nicotiana simulans (section Suaveolentes). Reciprocal hybrid seedlings were inviable at 28 °C, and the lethality was characterized by browning of the hypocotyl and roots, suggesting that hybrid lethality is due to the interaction of nuclear genomes derived from each parental species, and not to a cytoplasmic effect. Hybrid lethality was temperature-sensitive and suppressed at 36 °C. However, when hybrid seedlings cultured at 36 °C were transferred to 28 °C, all of them showed hybrid lethality. After crossing between an N. tabacum monosomic line missing one copy of the Q chromosome and N. simulans, hybrid seedlings with or without the Q chromosome were inviable and viable, respectively. These results indicated that gene(s) on the Q chromosome are responsible for hybrid lethality and also suggested that N. simulans has the same allele at the Hybrid Lethality A1 (HLA1) locus responsible for hybrid lethality as other species in the section Suaveolentes. Haplotype analysis around the HLA1 locus suggested that there are at least six and two haplotypes containing Hla1-1 and hla1-2 alleles, respectively, in the section Suaveolentes.
Swine Gastrointestinal Microbiota and the Effects of Dietary Amino Acids on Its Composition and Metabolism
Authors: Liao Shengfa F. , Ji Feng , Fan Peixin , Denryter Kristin
Published: January 2024

Many researchers consider gut microbiota (trillions of microorganisms) an endogenous organ of its animal host, which confers a vast genetic diversity in providing the host with essential biological functions. Particularly, the gut microbiota regulates not only gut tissue structure but also gut health and gut functionality. This paper first summarized those common bacterial species (dominated by the Firmicutes, Bacteroidota, and Proteobacteria phyla) in swine gut and then briefly discussed their roles in swine nutrition and health, which include roles in nutrient metabolism, pathogen exclusion, and immunity modulation. Secondly, the current knowledge on how dietary nutrients and feed additives affect the gut bacterial composition and nutrient metabolism in pigs was discussed. Finally, how dietary amino acids affect the relative abundances and metabolism of bacteria in the swine gut was reviewed. Tryptophan supplementation promotes the growth of beneficial bacteria and suppresses pathogens, while arginine metabolism affects nitrogen recycling, impacting gut immune response and health. Glutamate and glutamine supplementations elevate the levels of beneficial bacteria and mitigate pathogenic ones. It was concluded that nutritional strategies to manipulate gut microbial ecosystems are useful measures to optimize gut health and gut functions. For example, providing pigs with nutrients that promote the growth of Lactobacillus and Bifidobacterium can lead to better gut health and growth performance, especially when dietary protein is limited. Further research to establish the mechanistic cause-and-effect relationships between amino acids and the dynamics of gut microbiota will allow swine producers to reap the greatest return on their feed investment.
Citric Acid Promotes Immune Function by Modulating the Intestinal Barrier
Authors: Hu Pengcheng , Yuan Meng , Guo Bolun , Lin Jiaqi , Yan Shihong , Huang Huiqing , Chen Ji-Long , Wang Song , Ma Yanmei
Published: January 2024

Amidst increasing concern about antibiotic resistance resulting from the overuse of antibiotics, there is a growing interest in exploring alternative agents. One such agent is citric acid, an organic compound commonly used for various applications. Our research findings indicate that the inclusion of citric acid can have several beneficial effects on the tight junctions found in the mouse intestine. Firstly, the study suggests that citric acid may contribute to weight gain by stimulating the growth of intestinal epithelial cells (IE-6). Citric acid enhances the small intestinal villus–crypt ratio in mice, thereby promoting intestinal structural morphology. Additionally, citric acid has been found to increase the population of beneficial intestinal microorganisms, including Bifidobacterium and Lactobacillus. It also promotes the expression of important protein genes such as occludin, ZO-1, and claudin-1, which play crucial roles in maintaining the integrity of the tight junction barrier in the intestines. Furthermore, in infected IEC-6 cells with H9N2 avian influenza virus, citric acid augmented the expression of genes closely associated with the influenza virus infection. Moreover, it reduces the inflammatory response caused by the viral infection and thwarted influenza virus replication. These findings suggest that citric acid fortifies the intestinal tight junction barrier, inhibits the replication of influenza viruses targeting the intestinal tract, and boosts intestinal immune function.
Combinatorial Gene Expression Profiling of Serum HULC, HOTAIR, and UCA1 lncRNAs to Differentiate Hepatocellular Carcinoma from Liver Diseases: A Systematic Review and Meta-Analysis
Authors: Lumkul Lalita , Jantaree Phatcharida , Jaisamak Kritsada , Wongkummool Wasinee , Lapisatepun Worakitti , Orrapin Santhasiri , Udomruk Sasimol , Lo Piccolo Luca , Chaiyawat Parunya
Published: January 2024

Hepatocellular carcinoma (HCC) presents a significant global health challenge due to limited early detection methods, primarily relying on conventional approaches like imaging and alpha-fetoprotein (AFP). Although non-coding RNAs (ncRNAs) show promise as potential biomarkers in HCC, their true utility remains uncertain. We conducted a comprehensive review of 76 articles, analyzing 88 circulating lncRNAs in 6426 HCC patients. However, the lack of a standardized workflow protocol has hampered holistic comparisons across the literature. Consequently, we herein confined our meta-analysis to only a subset of these lncRNAs. The combined analysis of serum highly upregulated in liver cancer (HULC) gene expression with homeobox transcript antisense intergenic RNA (HOTAIR) and urothelial carcinoma-associated 1 (UCA1) demonstrated markedly enhanced sensitivity and specificity in diagnostic capability compared to traditional biomarkers or other ncRNAs. These findings could have substantial implications for the early diagnosis and tailored treatment of HCC.
Better Communication for Better Management of Persons with Hemophilia: Results from a Patients’-Clinicians’ Project to Address the New Therapeutic Landscape
Authors: Banov Laura , Linari Silvia , Ambroso Luigi , Ferri Grazzi Enrico , Gallo Samanta , Pasqualetti Patrizio , Mancuso Maria Elisa
Published: January 2024

Applying the Delphi method, this study aims at characterizing the perceptions and needs of physicians, individuals with hemophilia, and their caregivers in relation to the management of routine visits during regular follow-ups. A single structured questionnaire, prepared by an advisory board, was administered to 139 participants, comprising hemophilia treaters, patients and caregivers, during the period from May to June 2023. Agreement (defined following the Delphi method as developed by RAND Corporation) was reached on several topics. The Principal Component Analysis methods identified the four most relevant areas where consensus was reached among the interviewees, underscoring the necessity for in-depth discussions during routine visits: (1) medical aspects related to symptoms, life-limitations, pain, etc.; (2) non-medical related aspects (ambitions, lifestyle, network, etc.); (3) logistical-organizational aspects (home–hospital distance, alternative modalities of communication); and (4) visit duration and telemedicine integration. The results of both the Delphi and Principal Component Analysis underline that the care of individuals with hemophilia extends beyond merely prescribing drugs or treatment regimens. Instead, it necessitates consideration of numerous variables from both therapeutic and non-therapeutic domains, all of which are deemed important for the holistic management of the individuals. As a result, these aspects are routinely discussed and addressed during visits.
Measuring the Intensity of Stress Experienced and Its Impact on Life in Patients with Diagnosed Alcohol Use Disorder
Authors: Curyło Mateusz , Czerw Aleksandra , Rynkiewicz-Andryśkiewicz Marlena , Andryśkiewicz Przemysław , Mikos Marcin , Partyka Olga , Pajewska Monika , Świtalski Jakub , Sygit Katarzyna , Sygit Marian , Karakiewicz Beata , Cipora Elżbieta , Kaczmarski Mateusz , Głowacka Mariola , Strzępek Łukasz , Drobnik Jarosław , Pobrotyn Piotr , Krzych-Fałta Edyta , Bandurska Ewa , Ciećko Weronika , Knyszyńska Anna , Porada Sławomir , Borzuchowska Monika , Kozlowski Remigiusz , Marczak Michał
Published: January 2024

Alcohol addiction is characterized by extensive alcohol consumption that dominates other behaviours previously important to a patient. According to data from The State Agency for Prevention of Alcohol-Related Problems, up to 900,000 people in Poland are addicted to alcohol. On average, approximately 9.7 L of pure alcohol per capita was consumed in 2021. Alcohol addiction may cause severe health problems and is one the key risk factors for various diseases. Stress plays an important role in the process of alcohol addiction and is also a predictor for lower enjoyment in life. On the other hand, sense of coherence may be a stronger protective factor. The aim of our study was to verify the relation between the level of perceived stress among patients with alcohol addiction and satisfaction with life. Because sense of coherence is a disposition that allows for managing stress effectively, the latter should be reflected in the results of multivariate analyses that take both the level of stress and sense of coherence into account. In the present study, sense of coherence and perceived stress were negatively correlated; therefore, strengthening internal resources for managing difficult and stressful situations is recommended.
Comparison of Combined Parenteral and Oral Hormonal Contraceptives: A Systematic Review and Meta-Analysis of Randomized Trials
Authors: Vleskó Gábor , Meznerics Fanni Adél , Hegyi Péter , Teutsch Brigitta , Unicsovics Márkó , Sipos Zoltán , Fehérvári Péter , Ács Nándor , Várbíró Szabolcs , Keszthelyi Márton
Published: January 2024

Background: Delivering contraceptive hormones through a transdermal patch or a vaginal ring might have advantages over the traditional oral route. Objectives: To compare the effectiveness, compliance, and side effect profile of oral and parenteral drug administration methods. Methods: We performed a systematic literature search in four medical databases—MEDLINE (via PubMed), Cochrane Library (CENTRAL), Embase, and Scopus—from inception to 20 November 2022. Randomized controlled trials assessing the efficacy, compliance, and adverse event profile of combined parenteral and oral hormonal contraceptives were included. Results: Our systematic search provided 3952 records; after duplicate removal, we screened 2707 duplicate-free records. A total of 13 eligible studies were identified after title, abstract, and full-text selection. We observed no significant difference in contraceptive efficacy (Pearl Index) between oral and parenteral drug administration (MD = −0.06, CI: −0.66–0.53; I2 = 0%). We found significant subgroup differences between parenteral methods in terms of compliance (χ2 = 4.32, p =0.038, I2 = 80%) and certain adverse events: breast discomfort (χ2 = 19.04, p =0.001, I2 = 80%), nausea (χ2 = 8.04, p =0.005, I2 = 75%), and vomiting (χ2 = 9.30, p =0.002; I2 = 72%). Conclusion: Both parenteral and oral contraceptives can be used as an effective contraceptive method, and the route of administration should be tailored to patient needs and adverse event occurrence.
The Kynurenine Pathway in Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis of Blood Concentrations of Tryptophan and Its Catabolites
Authors: Cavaleri Daniele , Crocamo Cristina , Morello Pietro , Bartoli Francesco , Carrà Giuseppe
Published: January 2024

Preliminary evidence shows that the kynurenine pathway (KP) may be altered in attention-deficit/hyperactivity disorder (ADHD). We thus conducted a systematic review and meta-analysis exploring the peripheral blood concentrations of tryptophan catabolites (TRYCATs) in people with ADHD. We searched the main electronic databases up to 7th December 2023. Standardised mean differences (SMDs) with 95% confidence intervals (95%CIs) were used to compare TRYCAT concentrations between participants with ADHD and healthy controls (HCs). We included eight studies. Random-effects meta-analyses found higher kynurenine (SMD = 0.56; 95%CI: 0.04 to 1.08; p = 0.033; I2 = 90.3%) and lower kynurenic acid (SMD = −0.33; 95%CI: −0.49 to −0.17; p < 0.001; I2 = 0%) concentrations in people with ADHD compared to HCs. Additional analyses on drug-free children with ADHD showed higher tryptophan (SMD = 0.31; 95%CI: 0.11 to 0.50; p = 0.002; I2 = 0%) and kynurenine (SMD = 0.74; 95%CI: 0.30 to 1.17; p < 0.001; I2 = 76.5%), as well as lower kynurenic acid (SMD = −0.37; 95%CI: −0.59 to −0.15; p < 0.001; I2 = 0%) blood levels, as compared to HCs. Despite some limitations, our work provides preliminary evidence on KP alterations in ADHD that may suggest decreased neuroprotection. Further research is needed to clarify the role of the KP in ADHD.
Targeted Temperature Management for Patients with Acute Ischemic Stroke: A Literature Review
Authors: Binda Dhanesh D. , Baker Maxwell B. , Varghese Shama , Wang Jennifer , Badenes Rafael , Bilotta Federico , Nozari Ala
Published: January 2024

Despite significant advances in medical imaging, thrombolytic therapy, and mechanical thrombectomy, acute ischemic strokes (AIS) remain a major cause of mortality and morbidity globally. Targeted temperature management (TTM) has emerged as a potential therapeutic intervention, aiming to mitigate neuronal damage and improve outcomes. This literature review examines the efficacy and challenges of TTM in the context of an AIS. A comprehensive literature search was conducted using databases such as PubMed, Cochrane, Web of Science, and Google Scholar. Studies were selected based on relevance and quality. We identified key factors influencing the effectiveness of TTM such as its timing, depth and duration, and method of application. The review also highlighted challenges associated with TTM, including increased pneumonia rates. The target temperature range was typically between 32 and 36 °C, with the duration of cooling from 24 to 72 h. Early initiation of TTM was associated with better outcomes, with optimal results observed when TTM was started within the first 6 h post-stroke. Emerging evidence indicates that TTM shows considerable potential as an adjunctive treatment for AIS when implemented promptly and with precision, thereby potentially mitigating neuronal damage and enhancing overall patient outcomes. However, its application is complex and requires the careful consideration of various factors.
The Challenge of Single-Photon Emission Computed Tomography Image Segmentation in the Internal Dosimetry of 177Lu Molecular Therapies
Authors: Gawel Joanna , Rogulski Zbigniew
Published: January 2024

The aim of this article is to review the single photon emission computed tomography (SPECT) segmentation methods used in patient-specific dosimetry of 177Lu molecular therapy. Notably, 177Lu-labelled radiopharmaceuticals are currently used in molecular therapy of metastatic neuroendocrine tumours (ligands for somatostatin receptors) and metastatic prostate adenocarcinomas (PSMA ligands). The proper segmentation of the organs at risk and tumours in targeted radionuclide therapy is an important part of the optimisation process of internal patient dosimetry in this kind of therapy. Because this is the first step in dosimetry assessments, on which further dose calculations are based, it is important to know the level of uncertainty that is associated with this part of the analysis. However, the robust quantification of SPECT images, which would ensure accurate dosimetry assessments, is very hard to achieve due to the intrinsic features of this device. In this article, papers on this topic were collected and reviewed to weigh up the advantages and disadvantages of the segmentation methods used in clinical practice. Degrading factors of SPECT images were also studied to assess their impact on the quantification of 177Lu therapy images. Our review of the recent literature gives an insight into this important topic. However, based on the PubMed and IEEE databases, only a few papers investigating segmentation methods in 177Lumolecular therapy were found. Although segmentation is an important step in internal dose calculations, this subject has been relatively lightly investigated for SPECT systems. This is mostly due to the inner features of SPECT. What is more, even when studies are conducted, they usually utilise the diagnostic radionuclide 99mTc and not a therapeutic one like 177Lu, which could be of concern regarding SPECT camera performance and its overall outcome on dosimetry.
Robust Positioning Estimation for Underwater Acoustics Targets with Use of Multi-Particle Swarm Optimization
Authors: Ge Xiyun , Zhou Hongkun , Zhao Junbo , Li Xiaowei , Liu Xinyu , Li Jin , Luo Chengming
Published: January 2024

With the extensive application of sensor technology in scientific ocean research, ocean resource exploration, underwater engineering construction, and other fields, underwater target positioning technology has become an important support for the ocean field. This paper proposes a robust positioning algorithm that combines the disadvantages of distributed estimation and particle swarm optimization, which can solve the large localization error problem caused by uncertainties in underwater acoustic communication and sampling processes. Considering the presence of ranging anomalies and sampling packet loss in underwater acoustic measurements, a weighted coupling filling method is used to correct the outliers in an underwater acoustic ranging signal. Based on the mapping model from the element array to the underwater acoustic responder, an unconstrained optimization algorithm for one-time localization estimation of underwater acoustic targets was established. Based on the one-time localization estimation results of underwater acoustic targets, an improved multi-particle swarm optimization estimation based on interactive search is proposed, which improves the accuracy of underwater target localization. The numerical results show that the positioning accuracy of the proposed algorithm can be effectively enhanced in cases of distance measurement errors and azimuth measurement errors. Compared with the positioning error before optimization, the positioning error can be reduced after optimization. Additionally, the experiment was carried out in the underwater environment of Hangzhou Qiandao Lake, which verified the positioning performance of the proposed algorithm.
Deciphering Preferences for Shelter Volume and Distribution by Coral Reef Fish, Using Systematic and Functional Grouping
Authors: Shabi Tamar , Ziv Yaron , Yosef Reuven , Shashar Nadav
Published: January 2024

Global degradation of coral reefs is reflected in the destruction of shelters in various environments and threatens the stability of marine ecosystems. Artificial shelters offer an alternative, but their design could be more challenging due to limited knowledge regarding desired inhabitants’ shelter characteristics and preferences. Investigating these preferences is resource-intensive, particularly regarding small shelters that mimic natural reef conditions. Furthermore, for statistical analysis in small shelters, fish abundance may need to be higher. We propose a method to characterize the species-specific shelter preferences using low-volume data. During a study conducted from January 2021 to April 2022, round clay artificial shelters (RAS) were deployed on an abandoned oil pier to examine a coral reef fish community. We recorded 92 species from 30 families and grouped them into systematic (families) and functional (dietary group) classes. Grouping enabled us to examine each group’s preference, while crossing these group preferences revealed species-specific preferences, which matched field observations. This approach proved effective in profiling the shelter preferences of 17 species while having limited resources. These profiles may later allow the establishment of ecological-oriented artificial reefs. Moreover, this method can be applied to other applications using other shelter designs, sizes, and research sites.
Experimental Investigation on the Motion Characteristics of Air-Floating Tripod Bucket Foundation during Free Floating
Authors: Liu Xianqing , Ding Yu , Li Wenlong , Zhang Puyang , Yu Kui , Feng Yutao , Lv Nan , Luo Sheng
Published: January 2024

In recent years, multi-bucket foundations have been studied and gradually adopted in engineering practices as a novel foundation for offshore wind turbines within a range of water depth of 30 to 50 m. This study investigated the motion characteristics of air-floating tripod bucket foundation (AFTBF) through a series of experiments during free air-floating. The experimental results show that the surge force appears to be the most important factor influencing pitch moment and motion, whether it is a change in water depth or a draft for AFTBF. The maximum amplitudes of surge acceleration and pitch angle show a trend of increasing with narrower spacing and decreasing with wider spacing, while the heave acceleration shows an opposite trend. The added mass and damping of heave motion for AFTBF increase with shallower water due to the increasing pressure difference between the inside and bottom of bucket foundation. The shallower the water depth and the larger the draft, the longer the resonance period of heave.
Numerical Modeling of Composite Load-Induced Seabed Response around a Suction Anchor
Authors: Ma Jingyao , Zhao Hongyi , Jeng Dong-Sheng
Published: January 2024

Suction anchors play a crucial role as marine supporting infrastructure within mooring systems. In engineering practice, the composite load comprising nonlinear waves and cyclic pull-out loads can have adverse effects on the seabed soil, posing a threat to the pull-out bearing capacity of the suction anchor. While existing research predominantly focuses on cyclic pull-out loads, the influence of nonlinear wave actions at the seabed surface remains overlooked. This study employs a two-dimensional integrated numerical model to investigate the dynamic soil response around a suction anchor under the influence of both nonlinear waves and cyclic pull-out loads, focusing on the mechanisms that lead to liquefaction and the deterioration of the interfacial friction due to the excess pore pressure buildup. The numerical results reveal that the cyclic pull-out load is the primary factor in the deterioration of the frictional resistance at the suction–soil interface, especially when the pull-out load is inclined with the suction anchor. Parametric studies indicate that the relative difference in frictional resistance deterioration between cases considering and excluding surface water waves becomes more pronounced in soils characterized by a small consolidation coefficient (Cv) and relative density (Dr).
Agriculture Named Entity Recognition—Towards FAIR, Reusable Scholarly Contributions in Agriculture
Authors: D’Souza Jennifer
Published: January 2024

We introduce the Open Research Knowledge Graph Agriculture Named Entity Recognition (the ORKG Agri-NER) corpus and service for contribution-centric scientific entity extraction and classification. The ORKG Agri-NER corpus is a seminal benchmark for the evaluation of contribution-centric scientific entity extraction and classification in the agricultural domain. It comprises titles of scholarly papers that are available as Open Access articles on a major publishing platform. We describe the creation of this corpus and highlight the obtained findings in terms of the following features: (1) a generic conceptual formalism focused on capturing scientific entities in agriculture that reflect the direct contribution of a work; (2) a performance benchmark for named entity recognition of scientific entities in the agricultural domain by empirically evaluating various state-of-the-art sequence labeling neural architectures and transformer models; and (3) a delineated 3-step automatic entity resolution procedure for the resolution of the scientific entities to an authoritative ontology, specifically AGROVOC that is released in the Linked Open Vocabularies cloud. With this work we aim to provide a strong foundation for future work on the automatic discovery of scientific entities in the scholarly literature of the agricultural domain.