bluuebunny/crossref_metadata_2025 huggingface dataset:
GÜZELLİK SALONLARINDAN HİZMET ALAN TÜKETİCİLERİ BEKLENTİLERİNE GÖRE ALT PAZAR BÖLÜMLERİNE AYIRMA ÜZERİNE BİR ARAŞTIRMA
Authors: CANDAN Burcu , BİLGİLİ Bilsen
Published: February 2020

Heterojen yapıya sahip olan pazarlarda farklı beklenti içerisinde olan tüketicilerin tatmin edilebilmesi için benzer grupların ortaya çıkarılması çağdaş pazarlama anlayışı açısından oldukça önemlidir.Hizmet sektöründe hızla pazarı büyüyen hizmetlerden biri de güzellik salonu hizmetleridir. Kadınların sosyal yaşam ve çalışma hayatındaki etkinliklerinin artmasıyla birlikte oldukça önemli bir hizmet sektörü haline gelen güzellik salonları her geçen gün yeni hizmetlerle müşterilerinin karşısına çıkmaktadır.Bu bağlamda hızla büyüdüğü gözlenen bu pazardaki kadın tüketicilerin beklentilerinin ortaya konularak, bu tüketicilerin güzellik salonlarına yönelik beklentileri açısından benzer gruplarda yer alıp almadıkları belirlenmeye çalışılarak pazar incelenmeye çalışılmıştır. Elde edilen sonuçlara göre pazarda homojen 3 alt küme belirlenmiş, sonuçlar yorumlanmış ve önerilerde bulunulmuştur.
KOBİ YÖNETİCİLERİNİN TEKNOLOJİYE BAKIŞ AÇILARININ BELİRLENMESİNE YÖNELİK AÇIKLAYICI BİR ARAŞTIRMA: BALIKESİR İLİ ORGANİZE SANAYİ BÖLGESİ ÖRNEĞİ
Authors: ALTAY Hüseyin , İLBAN Mehmet Oğuzhan
Published: February 2020

Bu çalışmada, faktör analizi kullanılarak Balıkesir İli Organize Sanayi Bölgesinde faaliyet gösteren Küçük ve Orta Ölçekli İşletme yöneticilerinin teknolojiye bakış açıları araştırılmıştır. Teknoloji, işletmelere haberleşmede, üretimde, vb., birçok konuda büyük kolaylıklar sağlamaktadır. Teknolojinin sağladığı bu olanaklardan yararlanmak; işletmelerin teknoloji yönetimine, rekabete, kalifiye personele, gelişme ve büyüme stratejilerine doğrudan bağlı görülmektedir. Anket çalışması ile elde edilen araştırma bulgularına göre işletme yöneticileri, “Teknoloji”ye genel olarak “günün vazgeçilmez koşullarından bir tanesi olduğu” ve “faaliyetlerinin her aşamasında yoğun olarak kullanılması gerektiği” gibi çağdaş bir bakış açısıyla yaklaşmaktadırlar. Faktör analizi sonucunda işletme yöneticileri teknolojiye sahip olabilme ve kullanabilmeyi, teknolojik avantajlardan yararlanabilme ve hukuksal yönü öncelikli faktörler olarak algılamaktadırlar. Ayrıca yöneticiler, personelin teknolojiye uyumu kadar teknoloji üretiminin gerçekleştirilmesini, yeniliklerin takip edilerek gerektiğinde teknolojinin transfer edilmesi konularını da birer faktör olarak tanımlamaktadırlar. Bununla birlikte, elde edilen sonuçlar dikkatle incelendiğinde yöneticilerin bazı konularda birtakım eksikliklerle karşı karşıya oldukları da görülmüştür.
Determination of an impulsive diffusion operator from interior spectral data
Authors: Khalili Yasser , Baleanu Dumitru
Published: February 2020

In the present work, the interior spectral data is used to investigate the inverse problem
for a diffusion operator with an impulse on the half line. We show that the potential functions

q
0

⁢

(
x
)

{q_{0}(x)}

and

q
1

⁢

(
x
)

{q_{1}(x)}

can be uniquely established by taking a set of values of the
eigenfunctions at some internal point and one spectrum.
Bakhtin and Shpet – Inheritance and Transcendence
Authors: Xiao Jingyu , Wang Ruofan
Published: February 2020

In the history of Russian philosophy of language, Bakhtin and Shpet are two very important figures. As scholars having reached the peak of academic humanities, they both scored great achievements in many fields. The contributions they made to semiotics have a direct impact on the semiotic view of the Moscow-Tartu School and other scholars who later represented the highest achievements of Russian semiotics. It was many years earlier than Bakhtin that Shpet put forward views similar to those of Bakhtin. But Bakhtin surpassed Shpet and extended semiotics to a broader humanistic space.
Dynamic Coherence in the Dialogue of Subjects
Authors: Ye Danmin , Wang Dongzhu
Published: February 2020

As the subjects to create and construct coherence in discourses, human beings should become the focus of coherence study. This paper points out the linguistic philosophical nature of discourse coherence and discusses the existence, dynamicity, and plasticity of dialogicity among subjects in coherence based on Bakhtin’s Theory of Dialogue. We demonstrate the construction of coherence on the basis of intentional space, which consists of theme, subject, and the whole context (or TSW structure). This paper analyzes two poems, one a Chinese poem and the other an English poem, as examples to verify the existence, dynamicity, and plasticity of dialogicity among subjects in the coherence space construction process. We also apply the TSW structure to the analysis of these two poems. This study provides discourse subjects with helpful tips and enhances comprehension of the discourse.
The simulation approach to the interpretation of archival aerial photographs
Authors: Siok Katarzyna , Ewiak Ireneusz
Published: February 2020

Archival aerial photographs obtained in the 20th century play a special role in the process of upgrading the register of land and buildings. These photographs are the only resource presenting credible information on the coverage and use of land in a high degree of detail. In this article, particular attention is paid to the aspect of the spectral resolution of archival aerial photographs. Preliminary research was conducted into the assessment of the impact of simulations of new spectral bands with high spatial resolution for archival photographs upon the interpretation process of such data. The proposed simulation method of new bands is based on the integration of archival monochromatic aerial images with archival multispectral satellite imagery. Visual and quantitative comparative analysis of monochromatic imagery and of enhanced images obtained by application of the simulation process was performed. The results of this research unanimously confirmed the improved interpretation possibilities of archival aerial photographs, associated not only with the assignment of colours but also with the reconstruction of spectral information for the arable and afforested land photographed.
Strengthening health care worker engagement with early adolescence in low- and middle-income countries: an overdue area for action
Authors: Sommer Marni , Daly Garrison , Kabiru Caroline , Lhaki Pema , Okwaro Neville , Chandra-Mouli Venkatraman
Published: February 2020

The very young adolescent population (ages 10–14) is currently under-served by health care systems, particularly in low- and middle-income countries. Although there is a substantial and growing effort to reach adolescents with the health services and commodities they need, such efforts often overlook the period of early adolescence given this population’s lower vulnerability to risk-taking behaviors. However, early adolescence is a period of significant change, with the onset of puberty introducing physiological, emotional, and social changes in girls’ and boys’ lives. This period also represents a time of intensifying gendered norms, and the transition of youth from childhood focused health care (e.g. deworming programs, nutrition interventions) to additional mid- and older adolescent related care [e.g. human papilloma virus (HPV) vaccine, and contraceptive provision). Strengthening young adolescents’ engagement with health care workers around preventative and promotive health behaviors could have profound impacts on their health and wellbeing, which in turn could have cascading effects across the course of their lives. Critically, young adolescents would gain trust in health care systems, and be more likely to return when significant health issues arise later in adolescence or adulthood. Such an effort requires sensitizing health care workers and building their capacity to respond to young adolescents’ unique needs, by defining a package of actions that they are mandated to provide, training them, providing them with desk reference tools, and putting in place systems to provide supportive supervision and collaborative learning on the one hand, and encouraging caregivers to connect their pubescent-aged boys and girls with the health care system, on the other hand. This paper presents an argument for increased focus in particular on building attitudes and capacities of health care workers on engaging with early adolescents, applying Principle 3 of the Society of Adolescent Medicine’s position paper entitled “Health Care Reform and Adolescents.”
Population viability analysis of common marsupials,Didelphis marsupialisandDidelphis virginiana, in a scenario of constant loss of native vegetation
Authors: Cruz-Salazar Bárbara , Ruiz-Montoya Lorena
Published: February 2020

We studied the population viability of two common marsupials,Didelphis marsupialisandDidelphis virginiana, based on field data and published ecological and genetic information. Using the VORTEX v. 10. 2.6 program, a 100-year simulation was performed with 1000 iterations for five populations ofD. marsupialisand six ofD. virginiana. A low probability of extinction was observed in both species, particularly forD. virginiana(0.000–0.007). Population size is higher considering a metapopulation dynamics approach versus individual populations for the two marsupials: 498.25 individuals forD. marsupialisand 367.41 individuals forD. virginiana. The estimated mean genetic diversity was high for bothD. marsupialis(He = 0.77–0.78) andD. virginiana(He = 0.79–0.82). The survival of both species over time could be expected to increase if a metapopulation dynamics is favored over the coming decades, despite a 1.3% loss rate of forest cover. The monitoring of population size and genetic diversity is highly recommended to validate the trends suggested by the model; this is especially true forD. marsupialis, a species associated with conserved areas that are becoming progressively less abundant. This research provides information on the responses of common mammalian species to environmental changes such as deforestation.
Mixed germ cell tumor of the endometrium: a case report and literature review
Authors: Zhang Heping , Liu Fangyun , Wei Jianguo , Xue Debin , Xie Zhengxin , Xu Chunwei
Published: February 2020

Germ cell tumors (GCTs) localized extragonadally are rare, with only 14 reported cases of a yolk sac tumor in the endometrium. Here we report a case of mixed endometrium GCTs in a 65-year-old postmenopausal woman with abnormal vaginal bleeding. An ultrasound examination showed an oval-shaped mass in the patient’s uterine cavity. Biochemical examination revealed elevated serum α-fetoprotein (AFP) at 359 ng/mL, whereas the tumor markers CA-125, CA-199, and CEA were all within normal range. Total hysterectomy and bilateral salpingo-oophorectomy were performed;. a histological examination revealed that the malignant components contained a yolk sac tumor, embryonal carcinoma, and focal immature teratoma. Immunohistochemical staining showed that AFPs were diffusively distributed in both the yolk sac tumor and embryonal carcinoma. The stem cell marker OCT3/4 was positive in the embryonal carcinoma component and that the pan-cytokeratin AE1/AE3 staining was positive in glandular areas. GFAPs (Glial Fibrillary Acidic Proteins) were positive in neuroectodermal tubules; the Ki-67 protein was positive in 90% of the tumor cells, whereas CD117 and placental alkaline phosphatase (PLAP) were negative. The cumulative evidence indicated mixed GCTs of endometrium as the final histopathological diagnosis. The patient received three courses of adjunct chemotherapy that provided good therapeutic efficacy as evidenced by the decreased serum AFP level. Our report on this rare case of mixed GCTs of the endometrium, supported by associated histological patterns and immunophenotypes and successful adjunct chemotherapy after surgery, could provide insight on future treatment of this rare but lethal disease.
Theoretical Studies of the Defect Structures for Cu(en)3
2+ and Ru(en)3
3+ Clusters in Tris(Ethylenediamine) Complexes
Authors: Liu Xu-Sheng , Wu Shao-Yi , Han Meng , Zhu Qing-Sheng
Published: February 2020

The local structures and spin Hamiltonian parameters (SHPs, g factors, and hyperfine structure constants) for the Cu(en)3
2+ and Ru(en)3
3+ clusters in ethylenediamine complexes are theoretically studied from perturbation formulae for tetragonally and trigonally elongated octahedral 3d9 and 4d5 clusters, respectively. Cu2+ centres I and II may experience the slight relative elongations ΔZ by about 0.005 and 0.007 Å in Zn(en)3(NO3)2 polycrystalline powder at 4.2 K and room temperature, respectively, along the C4 axis arising from the Jahn–Teller effect. For Ru(en)3
3+ cluster in the uniaxial [Rh(en)3Cl3]2NaCl ⋅ 6H2O single crystal doped with the single-crystal chloride salt [Ru(en)3]Cl3 ⋅ 4H2O, the local impurity–ligand bonding angle related to the C3 axis suffers a negative variation Δβ (≈−1.85°) with respect to the host βH in [Ru(en)3]Cl3 ⋅ 4H2O at 4 K. The features of SHPs and defect structures for the Cu(en)3
2+ and Ru(en)3
3+ clusters are also discussed in view of the different experimental temperatures.
Weights of the $\mathbb{F}_{q}$-forms of $2$-step splitting trivectors of rank $8$ over a finite field
Authors: Rakdi M.A. , Midoune N.
Published: February 2020

Grassmann codes are linear codes associated with the Grassmann variety $G(\ell,m)$ of $\ell$-dimensional subspaces of an $m$ dimensional vector space $\mathbb{F}_{q}^{m}.$ They were studied by Nogin for general $q.$ These codes are conveniently described using the correspondence between non-degenerate $[n,k]_{q}$ linear codes on one hand and non-degenerate $[n,k]$ projective systems on the other hand. A non-degenerate $[n,k]$ projective system is simply a collection of $n$ points in projective space $\mathbb{P}^{k-1}$ satisfying the condition that no hyperplane of $\mathbb{P}^{k-1}$ contains all the $n$ points under consideration. In this paper we will determine the weight of linear codes $C(3,8)$ associated with Grassmann varieties $G(3,8)$ over an arbitrary finite field $\mathbb{F}_{q}$. We use a formula for the weight of a codeword of $C(3,8)$, in terms of the cardinalities certain varieties associated with alternating trilinear forms on $\mathbb{F}_{q}^{8}.$ For $m=6$ and $7,$ the weight spectrum of $C(3,m)$ associated with $G(3,m),$ have been fully determined by Kaipa K.V, Pillai H.K and Nogin Y. A classification of trivectors depends essentially on the dimension $n$ of the base space. For $n\leq 8 $ there exist only finitely many trivector classes under the action of the general linear group $GL(n).$ The methods of Galois cohomology can be used to determine the classes of nondegenerate trivectors which split into multiple classes when going from $\mathbb{\bar{F}}$ to $\mathbb{F}.$ This program is partially determined by Noui L. and Midoune N. and the classification of trilinear alternating forms on a vector space of dimension $8$ over a finite field $\mathbb{F}_{q}$ of characteristic other than $2$ and $3$ was solved by Noui L. and Midoune N. We describe the $\mathbb{F}_{q}$-forms of $2$-step splitting trivectors of rank $8$, where char $\mathbb{F}_{q}\neq 3.$ This fact we use to determine the weight of the $\mathbb{F}_{q}$-forms.
Point-evaluation functionals on algebras of symmetric functions on $(L_\infty)^2$
Authors: Vasylyshyn T.V.
Published: February 2020

It is known that every continuous symmetric (invariant under the composition of its argument with each Lebesgue measurable bijection of $[0,1]$ that preserve the Lebesgue measure of measurable sets) polynomial on the Cartesian power of the complex Banach space $L_\infty$ of all Lebesgue measurable essentially bounded complex-valued functions on $[0,1]$ can be uniquely represented as an algebraic combination, i.e., a linear combination of products, of the so-called elementary symmetric polynomials. Consequently, every continuous complex-valued linear multiplicative functional (character) of an arbitrary topological algebra of the functions on the Cartesian power of $L_\infty,$ which contains the algebra of continuous symmetric polynomials on the Cartesian power of $L_\infty$ as a dense subalgebra, is uniquely determined by its values on elementary symmetric polynomials. Therefore, the problem of the description of the spectrum (the set of all characters) of such an algebra is equivalent to the problem of the description of sets of the above-mentioned values of characters on elementary symmetric polynomials.

In this work, the problem of the description of sets of values of characters, which are point-evaluation functionals, on elementary symmetric polynomials on the Cartesian square of $L_\infty$ is completely solved. We show that sets of values of point-evaluation functionals on elementary symmetric polynomials satisfy some natural condition. Also, we show that for any set $c$ of complex numbers, which satisfies the above-mentioned condition, there exists an element $x$ of the Cartesian square of $L_\infty$ such that values of the point-evaluation functional at $x$ on elementary symmetric polynomials coincide with the respective elements of the set $c.$
Просторовий розподіл кореневої системи обліпихи крушиновидної на різних варіантах рекультивації порідних відвалів Західного Донбасу
Authors: Masiuk O. M.
Published: February 2020

У результаті досліджень було встановлено, що формування кореневої системи21-річних насаджень обліпихи крушиноподібної в техноземах залежить від якості посадочного матеріалу і глибини його посадки в ґрунт; від потужності і якості відсип-ки древньоалювіальних відкладень і родючого шару ґрунту на поверхню шахтнихпорід, яка є нижньою межею корененаселеного шару рекультивованого едафотопу ітим самим обмежувачем зростання і розвитку рослин.
Динаміка активності пероксидази у листках Ailanthus altissima за аеротехногенного забруднення
Authors: Legostayeva T. V. , Volyanyk K. O.
Published: February 2020

З’ясовано зміну активності антиоксидантного ферменту пероксидази у лист-ках рослин Ailanthus altissima Swingle, які зростають в умовах урбоценозу м. Дніпро.Встановлено, що адаптація деревної породи Ailanthus altissima Swingle до дії забруд-нювачів урбоценозів відбувається за рахунок активації антиоксидантного ферментупероксидази. Зазначено, що показник активності пероксидази можна з великим сту-пенем достовірності використовувати для оцінки стану деревних рослин у стресовихумовах і їх стійкості до аеротехногенного забруднення.
Вплив викидів Придніпровської ТЕС м. Дніпро на анатомічні показники стебла однорічного пагона представників роду Аcer
Authors: Gritsay Z. V. , Nalivaichenko A. V.
Published: February 2020

Наведено результати дослідження впливу хронічного забруднення довкілля ви-кидами Придніпровської ТЕС м. Дніпро на анатомічні показники стебла однорічно-го пагона представників роду Acer. У вивчених об’єктів на техногенно забрудненійділянці встановлено зміни розмірів гістологічних елементів стебла, характер якихмає видові відмінності. У A. pseudoplatanus за дії токсичних викидів ТЕС виявленозбільшення ширини первинної кори стебла й окремих її складових (корку, коленхі-ми, корової паренхіми) та підтримання стабільних розмірів вторинної кори, її гісто-логічних елементів (твердого й м’якого лубу), також деревини, що ми розглядаємояк показники відносної стійкості даного виду в техногенному середовищі. У A. platanoidesза дії токсикантів встановлено збільшення ширини корку, корової паренхімий загальної товщини первинної кори, що може забезпечувати певну толерантністьрослин за несприятливих умов. Разом з тим у A. platanoides у забрудненій зоні вияв-лено зменшення розмірів коленхіми, твердого лубу, м’якого лубу, що в сукупностіможе зменшувати механічну міцність стебла, порушувати пересування розчинів ор-ганічних речовин по системі спеціалізованих провідних тканин, і, таким чином, під-вищувати вразливість рослин даного виду на техногенних територіях. Надано реко-мендації щодо залучення досліджених видів р. Acer до озеленення промислових зон вумовах Степового Придніпров’я.
Cезонна динаміка консортивних зв’язків птахів з дубом звичайним (Quercus robur)
Authors: Ponomarenko O. L.
Published: February 2020

Досліджено міжсезонну динаміку консортивних зв’язків птахів в індивідуаль-них консорціях дуба звичайного. Проаналізовано показники загального бюдже-ту часу птахів на одне ядро консорції, його динаміку по сезонах, видовий склад тачисельність птахів-консортів протягом року. Виявлено, що система консортивнихзв’язків птахів протягом року на віргінільному дубі має стохастичний характер.На молодому генеративному дубі, протягом року домінують трофічні взаємодії. Настарому генеративному дубі, крім інтенсивних трофічних зв’язків, птахи протягомроку реалізують також численні топічні зв’язки. Стабільність системи консортив-них зв’язків птахів з дубом звичайним зростає в напрямку від віргінільного до ста-рого генеративного.
Invasive leafminer moths (Gracillariidae stainton, 1854) in fauna of the Botanical Garden of Oles Honchar Dnipro National University
Authors: Holoborodko K. K. , Rusinov V. S. , Seliutina O. V.
Published: February 2020

History of Lepidoptera adventitious species invasion on territory of the Botanical Garden of the Oles Gonchar Dnipro national university dates back over 15 years. During this period, four invader species belonging to leaf blotch miner moth family (Gracillariidae Stainton, 1854) were found: horse-chestnut leaf miner (Cameraria ohridella Deschka et Dimić, 1986), lime leaf miner (Phyllonorycter issikiimama, 1963), black locust leaf miners (Parectopa robiniella Clemens, 1863 and Phyllonorycter robiniella Clemens, 1859).

Spectrum of trophic relationships of leaf-mining lepidoptera invasive complex on territory of the Botanical Garden was established, invading species of the family Gracillariidae were found on horse chestnut leaves (Aesculus hippocastanum L., 1753), Norway maple (Acer platanoides L., 1753), and linden european (Tilia ×europaea L., 1753).

Assessment of leaf damage status was provided. The largest damages were registered on horse chestnut, up to 80% trees of which were completely defoliated by the end of summer period, which eventually leads to drying out and subsequent death of the trees.

Of particular concern is outbreak of black locust leafminer moths complex. For the first time their mines were registered in 2007. Since then, it can be stated that all Robinia trees growing in the botanical garden were settled with the miners. Statistical processing data obtained during the morphological studies of mines of both species indicate a their great ecological plasticity.

The most recent invasion of adventitious species Gracillariidae can be considered the emergence of Phyllonorycter issikii. The first registrations were carried out in 2015; since then the species is recorded annually on Tilia cordata. For all the time of observation, this species did not show a tendency to increase in numbers, and it has not been registered on other Tilia species.
MACHINE LEARNING FOR SOFTWARE
Authors: Mahmudova Shafagat
Published: February 2020

The study machine learning for software based on Soft Computing technology. It analyzes Soft Computing components. Their use in software, their advantages and challenges are studied. Machine learning and its features are highlighted. The functions and features of neural networks are clarified, and recommendations were given.
Sobre a ideia de uma teologia da cultura de consumo - Ensaio de um olhar tillichiano sobre a cultura de consumo
Authors: Santos Victor Siqueira
Published: February 2020

Este ensaio visa apontar um caminho para a construção de uma teologia da cultura de consumo a partir da teologia da cultura de Paul Tillich. Para tal, o primeiro objetivo será entender, pelo viés antropológico, o que é e quais são as principais características da chamada cultura de consumo. Após, então, é pretendido mostrar a teologia da cultura de Paul Tillich como uma que visa superar a separação entre cultura e religião defendendo que toda e qualquer criação cultural é capaz de trazer consigo um conteúdo religioso. Portanto, é tarefa da teologia da cultura analisar tais manifestações culturais sempre do ponto de vista de seu conteúdo substancial (Gehalt). Como delimitação necessária, será considerado como fundamento teórico o texto Über die Idee einer Theologie der Kultur (Sobre a ideia de uma teologia da cultura), proferido por Tillich em 16 de abril de 1919 à Sociedade Kantiana de Berlim, visto que esta conferência é a primeira aparição pública de sua teologia da cultura. A hipótese consiste, por fim, em mostrar que, a partir da teologia tillichiana, é possível afirmar a cultura de consumo como uma esfera cultural que absolutiza o caráter autônomo da cultura, travestindo-a de teonomia.
Uma correlação sobre o mito da queda em Platão e Paul TIllich
Authors: Silva Edson Pereira
Published: February 2020

O presente texto tem como objetivo geral tratar sobre o mito da queda em correlação com o pensamento de Tillich com o de Platão. Por isso, o trabalho esta delimitado especificamente em três tópicos no qual o último é o seu ápice. No primeiro tópico discorreremos sobre o método de Correlação de Paul Tillich que é o instrumento na elaboração de perguntas e respostas para o problema da existência humana. No segundo do ponto de vista existencial da filosofia e da teologia faremos um percurso histórico sobre problema da essência e da existência. E por último analisaremos em correlação com Tillich e Platão a transição da essência para a existência a partir do mito da queda.
Tip 1 Diyabetli Çocuk ve Adolesanlarda Kardiyak Fonksiyonların Konvansiyonel Ekokardiyografi ile Erken Dönem Değerlendirilmesi
Authors: ÇETİNER Nilüfer , BOLU Semih , ALMIŞ Habip , İŞLEYEN Fatih , TURGUT Mehmet
Published: February 2020

Amaç: Kardiyak
disfonksiyonun tip 1 diyabetin ciddi ve sık görülen komplikasyonlarından biri
olduğu bilinmektedir. Bu çalışmanın amacı, tip 1 diyabet tanılı çocuk ve
adolesanların kardiyak etkilenmenin konvansiyonel ekokardiyografi ile erken
dönemde değerlendirilmesiydi.Gereç ve Yöntem: Çalışmada
53 tip 1 Diyabet tanılı çocuk ve adolesan ile benzer yaş ve cinsiyette 55
sağlıklı çocuk ve adolesan yer almaktadır. Katılımcıların, boy, kilo, vücut
kitle indeksi ve kan basıncı değerleri kaydedildi. Tip 1 diyabetli hasta
grubunda glisemik kontrol için glikolize hemoglobin ölçümü yapıldı. Tüm
katılımcıların miyokardiyal sistolik ve diyastolik  fonksiyonları 
konvansiyonel ekokardiyografi yöntemi ile değerlendirildi.Bulgular: Tip 1
diyabetli 53 hastada kontrol grubuna göre triküspid kapağın A dalga akım hızı
anlamlı yüksek (p=0,04) ve triküspid E/A oranı ise anlamlı düşük  (p=0,02) bulundu. Sol ventrikül fraksiyonel
kısalma ve ejeksiyon fraksiyonu hasta grubunda kontrole göre daha düşük
bulundu, ancak istatiksel olarak anlamlı değildi (p değerleri sırasıyla 0,675,
0,933). Hasta grubunda glikolize hemoglobin düzeyi ile sol ventrikül sistolik
fonksiyonu arasında ise istatiksel olarak anlamlı negatif korelasyon bulundu
(p= 0,049, r= -0,669).

Sonuç: Tip 1 diyabet
tanısı olan çocuk ve adolesanlarda erken dönemde bile ekokardiyografik olarak sağ
ventrikülde diyastolik disfonksiyon ve glikolize hemoglobin  düzeyi ile sol ventrikül ejeksiyon fraksiyonu
arasında negatif korelasyonun gösterilmesi, kötü glisemik kontrollü diyabetik hastaların
peryodik olarak kardiyak değerlendirmelerinin noninvazif tanı yöntemi olan
ekokardiyografi ile yapılmasının gerekli olduğunu düşündürmektedir
Factors in the Transition from Legal to Illicit Drug Use in Young Adults from Northern Mexico
Authors: Ozuna Esprinosa Mayra Selene , Candia Arredondo Josefina Saraí , Alonso Castillo María Magdalena , López García Karla Selene , Guzmán Facundo Francisco Rafael
Published: February 2020

Objective. This research sought to analyze the predictive effect of personal (personality traits), social (social support and social stigma) and community factors (characteristic of the neighborhood and exposure to consumption) on the transition of drug use in young adults.Methods. Case and control study. The cases were 70 individuals from 18 to 34 years of age who had already transitioned into illicit drug use and the controls were 210 legal drug usuers (tobacco or alcohol) in the same age range  who had not had the transition. A data file was applied along with seven instruments that measured the transition and consumption variables.Results. Marihuana was the illicit drug of highest transition. It was shown that greater personality traits of neuroticism, extraversion, and openness to the experience meant higher probability of drug use transition; while greater personality traits of agreeableness and conscience meant lower probability for the transition. The characteristics of the neighborhood environment and exposure to the opportunity of consumption increase the probability of the drug use transition. Social support and social stigma influenced negatively upon the drug use transition.Conclusion. Personality traits, neighborhood characteristics, exposure to drug use, social support, and the social stigma of drug use are factors that intervene in the transition from legal to illicit drug useDescriptores: street drugs; drug users; risk factors; young adult; personality; social support; social stigma; residence characteristics; surveys and questionnaires; case-control studies.How to cite this article: Ozuna  MS, Candia JS, Alonso MM,  López KS, Guzmán FR. Factors in the Transition from Legal to Illicit Drug Use in Young Adults from Northern Mexico. Invest. Educ. Enferm. 2019; 37(3):e11.
Project management: process approach
Authors: Sedykh Ekaterina P.
Published: February 2020

The problem of the effectiveness of the use of different approaches in the management of an educational organization is relevant and significant. Currently, there is a necessity to improve management processes and to formation of a more flexible and mobile management system that works on the result and allows to assess the effectiveness of activities at any point in the process. Project management has proven to be effective under conditions of limited funding and the necessity for "quick results". At the same time, we can observe certain conflicts of management actions that occur as a result of imposing a matrix structure of project management on the functional structure of a traditional educational organization. In this case, the process approach allows combining the advantages of project activities with the regulated implementation of traditional University processes.The paper reveals the logic of the process approach, its main advantages and disadvantages, requirements and principles of implementation of the process approach in an educational organization. This paper describes the practice of applying the process approach in the management of projects of Minin University: it characterizes the management processes of a project activity through the project office system, and the logic of a managing the chain of processes of individual projects.The author describes the logic of the process approach to project management, characterizes the strengths and weaknesses of process management, analyzes the combination of this approach with project management, describes the practice of applying the process approach to project management at Minin University, lists the effects of the introduction of the process approach in management.The final part of the paper discusses the possibility of further improvement of the project management system through the use of the process approach, the arguments about the necessity to use process management in combination with other management approaches, reveals the potential for improving the quality of project activities through the use of process management tools and principles of quality management of the organization, based on the process approach.
FRACTAL * MODEL OF CONSERVATIVE DEVELOPMENT (an example of trust algebra, that is, state building with a trust operation)
Authors: Chuiko Vadim , Atamanchuk-Angel Valery
Published: February 2020

In this article of the Doctor of Philosophy, professor of Taras Shevchenko Kyiv National University, Chuiko Vadim Leonidovich and Atamanchuk-Angel Valerii Ivanovich is applied the principle of «first philosophy» as the foundation of the a priori prerequisites of possible cognition, which define an existence in general rather than its individual parts. This application of metaphysics made it possible to introduce methods of «universal algebra» for the implementation of humanitarian research using algebraic description with the help of three notion: plural, operations, relation.
This methodological novation makes it possible to create demonstrative models of social systems, not their constructions, because constructionsare traditionally makeby using binary description that use only two notions, categories.
Question: How to fill the notion of «public agreement» with the actual content? How to make all generations participate in the adoption of a social contract? How to create a new one, without destroying it entirely, maintaining stability? How to ensure a high degree of mutation — rebuilding, rebuilding and construction?
Introduced in the algebraic sense, the notion of «trust» as a definition of what is necessary for the existence of a society of being as such, forms an algebra that models social relations by the operation of trust, not violence.
Based on the above, we can talk about creating a mathematical politics. Matpoliticsdeal with ideal political objects. Matpolitics is the activity of a summation of algebras. These algebras differ from each other by the choice of operations. Plurals that consist of different algebras can be the carrier of the algebra.
In this case, we are talking about the algebra of trust / credo, whose signature consists of the following operations: sovereignty, trust / credit, understanding of need for the Other, agreement and recursive procedures.
The result of the implementation of these methodological guidelines are the answers to the following questions: How to make the concept of «social agreement» really meaningful? How can all generations (and the unborn, too) be involved in the social agreement? How to create a new one, without destroying the foundations of the existing one, to realize the idea of conservative development: restructuring and building a new one?
Based on the provisions of the algebra of trust, society appears as a plurality of sovereigns — C, possessing the full range of rights to identify trust / distrust — Di, creating agreements — Yn, and for their completeness they have and understand the need for the other — Ik.
The model presented is a system of treaties that are not an abstract concept of the state, but an agreement with specific elected people who have gained the trust of those to whom they temporarily render their services. Agreements are urgent, limited by time frame, with obligatory full responsibility of the parties.
THE ECONOMIC KEYNOTE OF THE MODERN WAVE OF SEPARATISM IN THE EUROPEAN UNION
Authors: Hrubov Volodymyr , Danylenko Serhii
Published: February 2020

Separatism has long been present in Western Europe as a political and social phenomenon. In the 21st century, it is the most manifest in the most affluent and successful countries in the European Union, including the United Kingdom, Spain, Italy, Germany, and Belgium. The paradox of this phenomenon is that the political aspect of the issue, which represents the confrontation between the newly emerged elite of «disobedient territories» and the central authorities, is closely intertwined with the economic factor of regional inequality, which has historically been present in those countries.
The objective of the article is, therefore, to elucidate the economic factor in the separatist sentiments in the countries of Old Europe and the role of regional political elites in the formation of separatist sentiments.
The methodology used in the course of research includes a number of scientific methods. The historical method helped reveal the features of separatist sentiments in specific EU countries and the internal and external factors that have transformed these sentiments into a commonplace public stance. The comparative method allowed clarifying the peculiarities of separatist movements in particular countries and the intentions of the political discourse in the political and legal field which they produce in order to support the view that secession is more beneficial to all than remaining within the ineffective state system. Finally, the dialectical method made it possible to identify political contradictions between governments and regions within their common history with delicate and contestable moments that secessionists seek to use in their struggle for independence.
The manifestation of separatism and secessionist policies by opposition forces has been analysed in Spain, Germany, and the United Kingdom.
It is noted that in the United Kingdom, where the rich province of Britain seeks to keep its political influence over the poorer provinces, separatist sentiments in Catalonia (Spain), Bavaria (Germany), South Tyrol (Italy), in Flanders and Wallonia (Belgium) are more akin to whims of human rationality, seeking for even more material possessions for already economically successful provinces with broad autonomy.
Based upon the analysis conducted, the following findings have been arrived at. First, European separatism is not a one-dimensional phenomenon and includes economic as well as political, ethnic and national motives. Second, European separatism varies from country to country: in the UK, it is categorical for long-term purposes and historically caused by the negative effects of colonization policies by the British in other provinces; in Spain, it is nationally and culturally specific, based on identity and history; and in Germany, it is «soft» in form and restrained in manifestation, with autonomy and federalization not destroying the state.
THE DEVELOPMENT OF SCIENTIFIC, ACADEMIC AND PRACTICAL CAPACITY OF RESEARCHERS AND EDUCATORS IN THE FIELD OF TRANSFORMATIVE DIGITAL LEARNING
Authors: Prudnikova Ilga
Published: February 2020

Transformative Digital Learning (TDL) is a progressive form of fully online, problem-based, constructivist learning, developed by research associates of the Educational Informatics Lab (EILAB), University of Ontario Institute of Technology, Canada. TDL transforms higher educational practices from: authoritarian instruction to democratized learning, individualistic learning to socially distributed and tool-mediated, knowledge building, a mechanism of the status quo to a catalyst for social progress, offer a truly novel approach to the theory of teaching and education, introduce new methodology and practical techniques to learners of all ages. Moving from lecture- and book-based, classroom learning to TDL proved to be a significant adjustment requiring a good level of participant readiness. The main aim of the project “Implementation of Transformative Digital Learning in Doctoral Program of Pedagogical Science in Latvia” is to create new pedagogical knowledge and technological know-how in the field of transformative digital learning (TDL) in higher education in Latvia based on Canadian experience and to ensure transfer of knowledge and skills in the further development of the doctoral study program "Pedagogy", as well as the development of scientific, academic and practical capacity of researchers and educators.The specific objectives of the research meet the main challenges and priorities of the project, originality and novelty in the field of research:Implementation of interdisciplinary research, capacity building and the creation of a new knowledge base by studying the situation and transferring innovation to implement TDL in doctoral studies;Development of new prototypes: e-platform, innovative methodologies (approaches, methods, techniques) for completing experiments, approbation, implementation and provision of new services in the context of higher education, which will provide world-wide recognized knowledge transfer in the development of innovative and advanced didactic materials which meet the most topical priorities of the Smart Specialization Strategy set out in Latvia:Productive innovation system; modern ICT; Modern education; Knowledge base; Information and Communication Technologies for Education and Economics.
Features of the dynamics of inflammation and apoptosis markers in patients with different acute post-stroke period
Authors: Zozulya S A , Otman I N , Chukanova A S , Klyushnik T P
Published: February 2020

The purpose of this was to study the dynamics of markers of inflammation and apoptosis in the serum of patients with ischemic stroke in the early post-stroke period. Materials and methods. The study involved 22 patients (mean age 60 ± 5.5 years) with different dynamics of neurological symptoms in the acute post-stroke period. Patients were examined twice: on the 1st and 10th day of observation. Quantitative assessment of the severity of neurological deficit using ESS and NIHSS scales was carried. Enzymatic activity of leukocyte elastase, functional activity of a1-proteinase inhibitor, level of autoantibodies to MBP (inflammatory markers), as well as the content of p53 and Bcl-2 proteins (markers of apoptosis) were determined in serum. The control group consisted of 35 somatically healthy people of the appropriate age and sex. Results. Identified the different features of the spectrum of the analyzed markers of inflammation and apoptosis in patients with positive and negative dynamics of neurological symptoms in the acute period of ischemic stroke assessed according to the ESS and NIHSS scales. The observed clinical and biological relationships reflect the features of the course of the early post-stroke period and can be considered as possible predictors of the development trajectory of acute brain ischemia.
MICROGLIA AND ASTROCYTES OF THE HUMAN BRAIN SUBSTANTIA NIGRA
Authors: Korzhevskii D E , Sufieva D A , Brovko M A
Published: February 2020

In recent years, attention of researches has focused on glial cells of different brain formations - astrocytes and microglial cells. This is due to active role of these cells in ensuring synaptic plasticity and regulation of neurogenesis. The study aimed at analyzing the structural organization of microglia and astrocytes of the human brain substantia nigra, which is the main dopaminergic nerve center. For the study, material from the archive of the Morphology Department (Institute of Experimental Medicine, Saint Petersburg, Russia) was used. Cells were detected using immunocytochemical markers (GFAP for astrocytes and Iba-1 for microglia). It has been established that microglial cells bodies in substantia nigra are located in neuropile singly. In pars compacta of substantia nigra these cells distributed relatively evenly, rarely being in close proximity to neurons. An unexpected fact was that the processes of microglia cells of the human brain substantia nigra have a sufficiently large thickness - 1.5-3 microns, which is not typical for a ramified microglia. Astrocytes of substantis nigra were characterized by the presence of very long processes (more than 100 microns) and the formation of the pericellular sheath around the nerve cells. These sheaths consisted of a dense interweaving of thin sparingly branched astrocyte processes. The processes of microglia were rarely present within such sheaths. The results obtained indicate moderate activation of microglia in substantia nigra and the special role of astrocytes in ensuring the compartmentalization of the pericellular zones in this nerve center.
EDITING THE BEHAVIOR OF EXPERIMENTAL ANIMALS MODULATED IN VITRO BY IMMUNE CELLS
Authors: Knyazheva M A , Serenko E V , Karpovich G S
Published: February 2020

The aim of the study is to edit the hyperactive behavior in experiments using immunocyte transplantation using in vitro modules with neuroleptic functional activity. Materials and methods. Experimental model: male mice (CBAxC57Bl/6) F1 of three months of age with hyperactive behavior. Immune cells were treated with chlorpromazine in a test tube, injected intravenously into the recipient, in which the behavior parameters in the open field test and the cytokine content in the brain were determined by ELISA. Results. Transplantation of precision and neuroleptic components contained in recipient mice is accompanied by a decrease in the indices of research and motor components, as well as the levels of IL-1β, IL-6 and TNFα cytokines in the brain.
CYCLOOXYGENASE MECHANISMS IN THE REGULATION OF RESPIRATORY EFFECTS OF TUMOR NECROSIS FACTOR
Authors: Danilova G A , Klinnikova A A , Aleksandrova N P
Published: February 2020

Introduction. It is known that the systemic level of the major pro-inflammatory cytokine increases in many respiratory diseases such as asthma, COPD and sleep apnea [1, 2]. The lung ventilation changes and the pathological types of breathing are typical in these diseases. By the reason, the research of the respiratory effects of cytokine is actual. The aim of this study was to compare the respiratory effects of tumor necrosis factor - α (TNF-α) before and after pretreatment with diclofenac, a nonspecific cyclooxygenase (COX) inhibitor. Materials and methods. Тhe experiments were performed in tracheostomized anaesthetized with urethane rats. A respiratory flow head connected to a pneumotachometer (AD Instruments ML141 Spirometer, Dunedin, New Zealand) was used to measure peak airflow and respiratory rate. The hypoxic ventilatory response was measured by using rebreathing with hypoxic gas mixture before and after the tail vein injection of TNF-α (10 μg/rat). In order to determine the role of the cyclooxygenase pathway in the ventilatory effects of TNF-α, introperitoneal administration of diclofenac, a nonspecific COX inhibitor, was used (0.5 mg/rat). Results and discussion. We have shown that the increase in level of TNF-α in blood increased the parameters of respiration such as minute ventilation (by 40%), tidal volume (by 18%), and the mean inspiratory flow (by 33%). The slope of the hypoxic ventilatory response decreased from 6.06 ± 0.91 to 3.48 ± 0.38 ml/min-1 mmHg-1 (by 40%) 40 min after administration of TNF-α (p < 0.05), the slope of tidal volume and mean inspiratory flow also decreased (by 27%) (p < 0.05). After pretreatment with diclofenac, the influence of TNF-α on breathing was dampened, as no significant changes were observed. Conclusion. We concluded that the elevation of inflammatory cytokine level in blood intensifies ventilation during the resting breathing that may be associated with increased central inspiratory activity. At the same time TNF-α reduces the chemoreflex sensitivity to hypoxia, thereby worsening the compensatory capabilities of the respiratory system. Thus, the results of our study suggest participation of inflammatory cytokines in mechanisms of central breathing control and chemoreception. Diclofenac pretreatment eliminated the respiratory effects of TNF-α. The data indicate that the ability of TNF-α to enhance basal ventilation and to reduce the ventilatory hypoxic response is mediated by the COX pathway.
STRESS-PROTECTIVE ACTION OF THYMUS PEPTIDES CONCERNING AGING RATS
Authors: Korolev A G , Novoseletskaya A V , Kiseleva N M
Published: February 2020

The survey objective is to check stress-protective action of thymus peptides concerning aging rats, experimentally. Methods used to study anxiety state were applied in tests with 18-months rats. It was found that thymus peptides in elevated plus maze (Thymosin fration 5 (0.5 mg/kg) and Thymulin (0.15 mg/kg)), and anxiolytic Diazepam (0.5 mg/kg) increased the motion activity in open arms, and number of positions onto hind legs in the light part of dark-light chamber. Influence of thymus peptides on the emotional stress associated with the failure of formated conditioned response of active avoidance was studied among aging rats. Within the control the failure caused a sharp decline in avoidance reactions and other demonstration of emotional tension. Thymus peptides and Diazepam prevented negative consequences on avoidance learning reactions. Thus, thymus peptides have demonstrated effect comparable to Diazepam in used models conditions. In avoidance learning model thymus peptides entirely prevented the consequences of emotional stress in ageing rats.