bluuebunny/crossref_metadata_2025 huggingface dataset:
Os prejuízos psiquiátricos causados pelo uso indiscriminado de anfetaminas
Authors: Ribeiro Yanna Clarisse Fontenele Costa , Nunes Melyssa Maria Fernandes da Rocha , Cavalcante Renata Sampaio Holanda , Bachur Tatiana Paschoalette Rodrigues
Published: October 2023

As anfetaminas são substâncias com capacidade de aumentar o desempenho cognitivo, assim como o nível de energia e concentração, possuindo indicação para pessoas diagnosticadas com Transtorno do Déficit de Atenção e Hiperatividade (TDAH). Um dos medicamentos mais utilizados nesta condição clínica é o cloridrato de metilfenidato, que estimula o sistema nervoso central (SNC). No Brasil, o fármaco é comercializado com o nome de Ritalina® e Concerta®. Embora sejam amplamente eficientes no tratamento do TDAH, em uso ilícito apresentam vários efeitos adversos. O uso excessivo pode acarretar aumento da fadiga, podendo levar a necessidade de mais estimulante, levando, consequentemente, à dependência física, psíquica, tolerância e habituação. Ante o exposto, este estudo tem como objetivo revisar a literatura científica sobre como o uso indiscriminado das anfetaminas e as consequências psíquicas deste uso. Para isso foi realizada pesquisa bibliográfica em três bases de dados (LILACS, MEDLINE e EMBASE), de onde foram selecionados artigos publicados de 2017 a 2023, sendo excluídas revisões bibliográficas e experimentos com animais. Aplicada a metodologia, foram utilizados seis artigos para a discussão. Após análise dos dados, observou-se a tendência ao uso indiscriminado das anfetaminas e outros estimulantes cerebrais e o desenvolvimento de transtornos psíquicos relacionados a este uso. Diante disso faz-se necessário um trabalho de conscientização do público adolescente e jovem quanto aos riscos do uso indiscriminado dessas substâncias e seus prejuízos para a saúde.
A Content Analysis of Postgraduate Thesis on Tennis Branch
Authors: COŞKUNTÜRK Osman Satı , ERKILIÇ Ali Ozan , YEL Kader , KURCAN Kübra
Published: October 2023

The aim of this study is to examine the postgraduate thesis studies prepared in the field of Tennis in terms of various variables and to provide guiding information to researchers by reminding certain criteria in writing thesis and abstract. This study is important in terms of showing the general situation of the postgraduate thesis abstracts in this field by analyzing the theses made in the postgraduate thesis studies related to the tennis branch. According to the data obtained from the studies in the National Thesis Center of the Presidency of the Council of Higher Education, it was determined that the total study was limited to 254. In this direction, it is necessary to encourage the increase in the research frequency and number of Master’s and Doctoral studies on tennis, and it is expected that the results and findings to be obtained with the guidance to be made in order to increase the frequency of the studies to be done will guide the researchers, educators and academics who will work in the field of tennis. It is thought that the contribution to the field will increase when more attention is paid to the research methodology part of the theses to be made and the academic advisors follow the process closely. The information given in the abstract is important for researchers and academics. It is expected that the information given in the abstract will be a guide for future studies. Knowing the research topics, methods and data analysis methods used in the field of tennis from the past to the present is of great importance for researchers who will conduct further studies. For this reason, it can be said that it is very useful to carry out similar studies frequently in order to determine the status of the studies in the field of tennis in Turkey or around the World.
The Practice of Islamic Psychospiritual Therapy in the Treatment of Drug Addiction at Rehabilitation Centres in Malaysia
Authors: Zainal Abidin M. Saiful Amri , M. Amin M. Zohdi , Salaeh Abdulloh , W. Yusoff W. Fatimah Zahra’ , Fa’atin Salmah
Published: October 2023

Drug addiction is a global problem and it also poses a threat to Malaysia. The Malaysian government through National Anti-Drug Agency (NADA) has implemented various approaches to eradicate drug abuse by providing rehabilitation centers and rehabilitation programs. Private institutions have also taken the same initiatives. One of the approaches in the recovery process used is Islamic psychospiritual therapy for Muslim addicts. However, the psychospiritual therapy program used varies and requires a holistic and comprehensive model. This study employed the qualitative approach through interviews with treatment center operators, observations of treatment center activities and text studies. It was conducted at several governments and private drug rehabilitation centers namely Cure & Care Rehabilitation Centre (CCRC) Tiang Dua, CCRC Sungai Ruan, Pondok Remaja Inabah Negeri Sembilan, Teratak Tautan Kaseh Murabbi and Persatuan Pengasih Malaysia. The study has revealed that Islamic psychospiritual therapy takes into account three main concepts and components that are tazkiyah al-nafs (soul purification), basic religious knowledge, and a therapeutic support system. Islamic psychospiritual therapy is found to help the government, private institutions and individuals to achieve the recovery of drug addicts especially in addressing the issue of relapse in drug addiction for Muslim addicts.
Thailand and the Middle-Income Trap: An Analysis from the Global Value Chain Perspective
Authors: Korwatanasakul Upalat
Published: October 2023

The study provides a critical analysis through the lens of the global value chain (GVC) framework with empirical data on value-added trade to explain Thailand's middle-income trap (MIT) by matching GVC data at the firm, industry, and country levels with the economic development trajectory. The results show that participation in GVCs contributes to initial industrialisation and economic development. However, it does not guarantee subsequent technological upgrading, as there is a risk of falling into the middle-income technology trap (MITT). Thailand is highly dependent on passive technology and specialisation imposed by headquartered countries, trapping the country in the middle of value chains with limited knowledge and technology transfer. As a result, Thailand has fallen into the MITT, where it cannot sustain growth and catch up with the more innovative advanced economies, leading to it falling into the MIT. To escape both traps, the government can consider policies that address inadequate knowledge and technology transfer and the lack of capacity of local firms.
DEL PROBLEMA A LA SOLUCIÓN INNOVADORA: UNA IDEA PRÁCTICA PARA INICIAR UN PROYECTO EDUCATIVO INNOVADOR
Authors: Araya-Guevara Aileen , Hidalgo-Durán Gloriana , Trigueros-Rodríguez EIthel Eduardo
Published: October 2023

Este artículo tiene como propósito conceptualizar y relacionar los términos innovación educativa y técnica de resolución de problemas, pues ambas prácticas pueden ser parte de un mismo proceso. Cuando se plantea una innovación educativa, se debe determinar cuál es el espacio, acción y momento en el que se llevará a cabo para generar el impacto deseado, es así, como la técnica mencionada le puede permitir a las personas, una estrategia para la identificación del problema y las posibles soluciones que originarán la innovación. Para llevar a cabo este aporte, se realizó una revisión bibliográfica al respecto como parte de un proceso de innovación a nivel de maestría en Tecnología e Innovación Educativa de la Universidad Nacional de Costa Rica.
A drawing hangs in the middle
Authors: Junuka Deshpande
Published: October 2023

This exposition is based on a project that explored observation of a crossroad through drawings. The drawings are made from the same place on a sidewalk observing the same square over 30 days. During this process, I tried to explore how a continuous observation of a space and the outcome of the process evokes a certain sense of connectedness and reflexive dialogue with the place and its elements- visible and invisible. This artistic research contemplates on the idea of too early too late through the process of drawing where the drawing emerges in the moment, while can be anticipated early and interpreted in hindsight.

My exposition considers the act of drawing as an embodied form of recording as opposed to drawing as an image-making (representational) exercise. This process of drawing becomes an engagement with the existing spatial elements, arrangements, their interconnections and importantly, with the self, that is observing. Along with the external engagement and a dialogue with the space, the moment of drawing is both- the outcome of observation and a connection in the moment of making it. This tension between an immediacy in the moment of drawing and the reflectivity in the process of meaning-making of the drawings creates a parallel relationship between an immediate present and the immediate past. The empty space on the surface before drawing, therefore becomes a potential space to record moments from the space around and to remember the moments that are passing by.

The work, in the form of drawings of various sizes aspires to present the engagement with the space. The work also gives me an opportunity to find critical moments in the records of time, memory and space. The drawing as an outcome hence, hangs in the middle between the moment of record and moment of being.
The etiologies of hearing loss in Meniere’s disease：Impairment of internal auditory canal barrier
Authors: Zhang Weidong , Xie Jiapei , Li Songbai , Zhang Bo
Published: October 2023

Objective: The aim of this investigation was to explore the
potential correlation between signal intensity ratio (SIR) at internal
auditory canal (IAC) bottom and hearing impairment in MD, thereby
providing a foundation for further comprehension of the underlying
mechanisms contributing to hearing loss. Design: Fifty patients
diagnosed with unilateral definited MD were enrolled in the study.
3D-FLAIR MRI was conducted four hours after intravenous administration
of gadobutrol to determine the SIR of bilateral IAC bottom. The
difference of SIR of IAC bottom was assessed between affected and
unaffected sides, followed by an analysis of its correlation with low-,
middle-, and high-tone hearing thresholds. Additionally, correlation
analysis was conducted between the degree of EH in vestibular and
cochlea and the SIR on the affected side. Results: The degree
of EH in MD can be clearly visualized through 3D-FLAIR MRI. The SIR on
the affected side was significantly higher than that on the unaffected
side (P=0.000). Furthermore, a positive correlation was observed between
the SIR at the affected and low (r=0.692, P=0.000), middle (r=0.615,
P=0.000) and high-tone (r=0.440, P=0.001); the SIR showed no significant
correlation with cochlear (r=0.315, P=0.088) or vestibular hydrops
(r=0.215, P=0.244). Conclusion: 3D-FLAIR MRI can observe the
degree of EH in MD; impairment of the internal auditory barrier may be
one of the factors of hearing loss in MD.
Comparing methods, species distribution data and spatial resolutions: Peninsula effect study on amphibian of Malay Peninsula
Authors: Badli-Sham Baizul Hafsyam , Ahmad Amirrudin , Grismer Larry
Published: October 2023

In macroecological studies, accurate species distribution information
and reliable methodologies are essential to illustrate the accurate
geographical distribution of organisms. The available distribution data
sources are generally limited to a particular geographical region and
studied taxa and often contain some degree of sampling bias that caused
a misrepresentation of species distribution. This study investigates how
the different distribution data, methods, and spatial resolution affect
the amphibian distribution pattern in the Malay Peninsula. Five types of
distribution data, namely point-based (simple point occurrences and
rarefied point occurrences) and range-based (expert-drawn range map,
modelled range map and hybrid range map), were assembled from the
published checklist, GBIF, natural history museum collections
information, and digital range maps. Species richness was point-to-grid
mapped by overlaying each distribution data with spatial resolutions of
100 km, 75 km, 50 km, 25 km and 15 km square grid and were evaluated
with descriptive and quantitative-based approaches. Overall results show
that richness maps created from range-based maps well-performed both
descriptive and quantitative. Spatial autocorrelation was present in all
distribution data; however, it is significantly reduced in 50 km
resolution in range-based maps. When mapped with different spatial
resolutions, the hybrid range map showed less variability in spatial
relatedness and structure and executed a better predictive performance.
The findings suggested that integrating the information from other
distribution sources reduces the erroneous information in particular
distribution data and can also evaluate the effects of spatial
resolutions before developing species distribution maps.
Beyond Metal--Air Battery, Emerging Aqueous Metal--Hydrogen Peroxide Batteries with Improved Performance
Authors: Liu Jiehua , Zhou Meng , Jin Ke , Li Jun , Meng Fancheng , Wei Xiangfeng
Published: October 2023

The aqueous metal-H2O2 batteries have been paying rapidly increasing
attention due to their large theoretical energy densities, high power
density, and multiple applications (air, land, and sea), especially in
low-content oxygen or nonoxygen conditions in which metal-air cells are
out of work. However, the requirements of metal-H2O2 batteries are
different due to the order of metal activities
(Mg>Al>Zn) as well as metal-air cells. Aqueous
metal-H2O2 batteries mainly include Al-H2O2, Mg-H2O2, and Zn-H2O2
batteries with respective scientific problems, including battery
structures, single/dual-electrolyte systems, electrocatalysts for oxygen
reduction/evolution reactions and H2O2
reduction/production/decomposition, and the designability of anode to
inhibit self-corrosion. In this review, we summarized battery
architectures, possible mechanisms, and recent progress in metal-H2O2
batteries including Al-H2O2, Mg-H2O2, and Zn-H2O2 batteries. Several
perspectives are also provided for these research fields, which may be
focused on in the future.
By their foes and by their kins --- endemic Chinese mountain cats are threatened by domestic dogs and cats
Authors: Wei Chunyue , Chen Huaiqing , Dong Zhengyi , Zhao Xiang , Lu Zhi , Shi Xiangying , Han Xuesong
Published: October 2023

The Chinese mountain cat (Felis bieti) is among the most elusive and
endangered felid species worldwide and is endemic to the eastern edge of
the Tibetan Plateau, China. Currently, the cat is assessed as Vulnerable
by the IUCN Red List based on its ‘likely small population’, ‘high
likelihood of fragmentation’, and “probably declining” trend.
Specifically, two human activities were identified by the previous
studies as the major threats that this unique lineage is faced with, as
the large-scale pika poisoning program and illegal hunting prevailing in
the area. However, during our monitoring of a breeding family discovered
in the Sanjiangyuan Region, two cats of the family were found dead and
were most likely killed by free-ranging dogs. Moreover, following
genetic analysis indicated that both cats were genetically contaminated
by local domestic cats. Consequently, based on the examination of the
carcasses, associate genetic analysis, and survey on free-ranging dogs,
in this study we identified two so far overlooked threats for the
Chinese mountain cats, as the killing by free-ranging dogs and genetic
contamination from domestic cats. These threats mark the tricky balance
among humans, domestic animals and wildlife in both historical and
recently burgeoning human activities, which requires further
investigation, research and conservation efforts.
The balance between hummingbird visitation rate and pollen deposition in rare and abundant plants.
Authors: Veluza Danila , Souza Tiago de , Varassin Isabela
Published: October 2023

Pollinator-mediated competition and facilitation are key to maintaining
plant communities by allowing rare and abundant species to coexist. To
understand the dynamics of these processes, we evaluated the effect of
dense dependence on visitation rates and pollen tubes in
hummingbird-pollinated plants. Furthermore, we calculate the functional
similarity and contribution of rare and abundant plants in competition
and facilitation. We identified negative dense-dependence on the
visitation rate, but with no effect on pollen tubes. Functional
similarity between rare and abundant plants did not vary in different
contexts of facilitation and competition, with greater functional
contribution by rare ones. Our results indicate the relevance of
conspecific abundance as a predictor to infer interactions and patterns
of functional diversity. The maintenance of both more similar and more
extreme traits from rare species may be another way to guarantee their
advantage in high heterospecific density.
Social cues and habitat structure affect the behaviour of a non-social insect
Authors: Marcantonio Matteo , Masier Stefano , Levier Mathilde Le , Kourtidis Argiris , Nieberding Caroline
Published: October 2023

Habitat fragmentation and loss is a known threat to biodiversity. Their
combined effect leaves organisms in small isolated patches of habitat,
contributing to the current biodiversity crisis. The first response of
animals to environmental change is typically behavioural. Beyond the
physical elements of the environment, the “social landscape” shapes
the spatial distribution of the habitats available to organisms. In this
article, we test the hypothesis that social cues and habitat structure
alter behaviours in a non-social insect. We tested 86 wild-caught L.
sinapis females from landscapes with various habitat structures in
outdoor cages reproducing habitats with or without social cues. We
demonstrate that the presence of same-sex congeners is a social signal
to remain within a suitable patch of habitat. We further show that
habitat structure is associated with oviposition success and investment
in navigation but not with emigration. Butterflies from small,
fragmented habitat patches relied more in routine movement and had lower
oviposition success. Like many other insects in Europe, L. sinapis is in
decline. Our results suggest that this decline may be exacerbated in
degraded habitats due to behavioural strategies selected by both
physical and social landscape elements.
The Role of DNAJB9 in the Pathogenesis of Triple Negative Breast Cancer: Case Report
Authors: Razdan Puneet , Wills Shannon , Razdan Priya , Severson Dawn , Osobamiro Omokayode
Published: October 2023

Background Triple negative breast cancer (TNBC) has been increasing in
incidence over the last 20 years, with reports of 2,088,849 cases of
TNBC in 2018 (2). Given its lack of treatment options, high recurrence
rate, and poor prognosis, there is a need to find new methods to help
drive treatment options for these patients (3). A previous study showed
a link between TNBC and a heat shock protein called DNAJB9, with
elevated levels of DNAJB9 demonstrating inhibition of
epithelial-mesenchymal transition of TNBC and thus protection against
metastasis (1). Case In this case study, we present a patient with
non-metastatic TNBC treated with neoadjuvant chemotherapy and resection
who had a complete pathologic response after receiving less than the
standard of care due to an adverse event. During her 3rd cycle of
chemotherapy, she developed acute DNAJB9-related fibrillary
glomerulonephritis. Conclusion This suggests that physiologically DNAJB9
may be upregulated in patients with TNBC for protection against
transformation and metastasis. Therefore, it postulates that measuring
the levels of DNAJB9 could potentially be used as a biomarker to
determine the response of the body to TNBC, thus functioning as a
prognostic indicator. Furthermore, pharmacologic treatments could be
developed that upregulate this process and serve as a cancer specific
therapy.
Modeling the Simultaneous Dropout of Energetic Electrons and Protons by Magnetopause Shadowing
Authors: Lyu Xingzhi , Tu Weichao , Huang Jinbei , Ma Qianli , Li Zhi Gu
Published: October 2023

Magnetopause shadowing (MPS) effect could drive a concurrent dropout of
radiation belt electrons and ring current protons. However, its relative
role in the dropout of both plasma populations has not been well
quantified. In this work, we study the simultaneous dropout of MeV
electrons and 100s keV protons during an intense geomagnetic storm in
May 2017. A radial diffusion model with an event-specific last closed
drift shell is used to simulate the MPS loss of both populations. The
model well captures the fast shadowing loss of both populations at high
L*, while the loss at lower L*, possibly due to the EMIC wave
scattering, is not captured. The observed butterfly pitch angle
distributions of electron fluxes in the initial loss phase are well
reproduced by the model. The initial proton losses at low pitch angles
are underestimated, potentially also contributed by other mechanisms
such as field line curvature scattering.
Multi-dimensional Weyl almost periodic type functions and applications
Authors: Kostic Marko , Fedorov Vladimir
Published: October 2023

In this paper, we analyze multi-dimensional Weyl almost periodic type
functions in Lebesgue spaces with variable exponents. The introduced classes
seem to be new and not considered elsewhere even in the constant coefficient
case. We provide certain applications to the abstract Volterra
integrodifferential equations in Banach spaces.
Some new results related to the constant e and function (1+1/x)x
Authors: Han Xue-Feng , Chen Chao-Ping , Srivastava H.M.
Published: October 2023

It is known that the constant e has the following series representations: e =
?? k=0 1/k! and e = ?? k=0 9k2+1/(3k)!. The second series is extremely
rapidly convergent. In this paper, we present asymptotic expansions and
two-sided inequalities for the remainders Rn and Rn, where Rn = e ? ?n k=0 1/k! and Rn=e??n k=0 9k2+1/(3k)!. Also, we present some inequalities and
completely monotonic functions involving (1 + 1/x)x. We also consider a
number of related developments on the subject of this paper.
Gestión financiera y su incidencia en la liquidez de la empresa Action Grown en la ciudad de Guayaquil, año 2022
Authors:   Instituto Superior Tecnológico Vicente Rocafuerte, Macías Enríquez Nicole Yaritza , Rivera Guerrero Alvaro ,   Instituto Superior Tecnológico Vicente Rocafuerte
Published: October 2023

La presente investigación se enfoca en la gestión financiera y la liquidez para determinar y descubrir métodos ayuden a mejorar la liquidez de las empresas, el cual tiene como objetivo determinar de qué manera la gestión financiera incide en la liquidez de la Empresa Action Grown en la ciudad de Guayaquil. La metodología que se aplicó fue de tipo básica de nivel descriptivo-correlacional, de enfoque cuantitativo, y de diseño no experimental de corte transversal, la técnica que se utilizó para recolectar información y datos fue mediante un cuestionario que consta de una encuesta de 23 preguntas que fueron encuestados a 10 trabajadores de la empresa Action Grown, luego de obtener la información se realiza el procesamiento de resultados mediante el programa estadístico SPSS versión 26 y se analizan cada resultado con frecuencias y porcentajes de manera descriptiva, luego se comprueban las hipótesis planteadas, se concluye que la gestión financiera incide significativamente en la liquidez de la Empresa Action Grown, el valor (sig.) fue 0.006, el cual es menor a 0.05, resultado que se acepta la hipótesis planteada, dado que una gestión financiera eficiente es una función vital y utilizando las herramientas adecuadas permitirá a los gerentes a tomar decisiones oportunas y hacer uso de los recursos de forma eficiente, el cual se reflejará con una buena liquidez y se cumplirán con las obligaciones en los plazos determinados
Feministiskt antikrigsmotstånd: Hur är det att som feminist kämpa mot Rysslands krig mot Ukraina?
Authors: Gradskova Yulia
Published: October 2023

Feministiskt antikrig motstånd (FAM – feministskoe antivoennoe soprotivlenie) var en av de första nätverken som offentligt visade sin protest mot Rysslands anfall av Ukraina februari 24 2022. Nu, när kriget fortsätter mer än ett år, kan man med säkerhet säga att FAM  inte bara fortsätter att vara en av dem mest konsekventa motståndare av kriget, men att den är också en av de mest radikala kritiker av de politiska och kulturella strukturer och värderingar som ligger till grund av ryska expansionismen.
This article is about the Feminist Anti-War Resistance (FAS), a network of activists within and outside Russia united in their support for LGBTQ+ rights and ready to resist the patriarchy and the Russian war on Ukraine. The article explores FAS’s ideas and tactics of activism.
Medicinal Utilization of Water Melon (Citrillus Lanatus) in Different Parts of Kaduna Southern Guinea Savanna of Nigeria
Authors: AI Sodimu
Published: October 2023

Proximate and medicinal utilization of watermelon (Citrillus lanatus) was examined in different parts of Kaduna Southern Guinea Savanna of Nigeria. Two hundred (200) questionnaires were randomly administered and one hundred and eighty-five (185) were retrieved. The results showed that watermelon can be used in the treatment and prevention of various diseases such as eye problems, skin disease, hypertension; reduce formation of kidney stones, renal stones, urinary stones, cough and catarrh, tuberculosis and many more. Majority (33.5%) of the respondents used grinding methods in preparing the seeds before use and the herbal mixture prepared are consumed fresh. The result of the proximate analysis showed that the seed contains 89.46% dry matter, 59.4% carbohydrate, 13.56% protein, 9.24% lipids. Other compositions in the seed are ash content (7.49%), crude fibre (8.81%). Demographic characteristics of the respondents were also examined. The percentage of male was 48.1% while that of female was 51.9%. Majority (52%) of the respondents is aged between 31 – 40 years and 53.5% are married. 54.6% of the respondents had secondary education while 86% had no formal education and majority (46.5%) is traditional healers. It is however recommended that agroforestry practices should be encouraged in the local government areas. Consequently, it must be ensured that watermelon fruits be the agricultural crop to be incorporated into the system for sustainability of the medicinal uses of the plant.
Assessing the Human Health Risk from Heavy MetalContaminated Vegetables Grown Close to the Tannery Industrial Area Using the Hazard Index (HI) and Hazard Quotient (HQ)
Authors: AS Chamon
Published: October 2023

To assess the contamination load in vegetables and its possible human health hazards, heavy metals concentration (Cr, Cd, Cu, Pb, Ni, and Zn) in vegetables grown in the vicinity of the studied tannery area were determined. Health risk due to the consumption of vegetables was calculated from the metal concentration of the studied vegetables and the study signifies more potential to cause health hazard (cancer) (Hazard Index>1). The present study indicated that concentrations of Cr in the vegetable species were within the range of 7.5-9.75, 5.38-10.14, 25.5-28.5 and 2.65 mg kg-1 of dry weight (DW), in bottle gourd fruit, bottle gourd shoot, kalmi shoot, and red amaranth, which was above the MPL (1-2 mg/kg). The findings revealed that the mean concentration of the studied heavy metals (Cr, Cd, Pb, Ni, Cu, Zn,) exceeded the MPL in most of the measured vegetables because of higher translocation from the source to edible parts. For the majority of the samples, the ADI values of Cr and Pb were higher than the PMTDI. Open dumping of tannery wastes and effluents, and tanning activities involve serious environmental hazards. Adequate preventive measures should be taken in tannery industrial activities with a view to ensuring a safe, sound, and healthy environment for the greater benefit of Bangladesh.
The Dynamics of Angiogenesis Markers in Patients with Obliterating Atherosclerosis after Surgical Treatment
Authors:   Ryazan State Medical University, Kalinin Roman E. , Suchkov Igor’ A. ,   Ryazan State Medical University, Krylov Andrey A. ,   Ryazan State Medical University,   Regional Clinical Hospital, Mzhavanadze Nina D. ,   Ryazan State Medical University, Pshennikov Aleksandr S. ,   Ryazan State Medical University, Nikiforov Aleksandr A. ,   Ryazan State Medical University
Published: October 2023

INTRODUCTION: The processes of regulation of blood circulation in any organism are in constant dynamic interaction due to the systems of pro- and anti-angiogenesis. The main proangiogenic factors include HIF1a, VEGF, PDGF. Depending on the concentration of these factors in the blood serum, it is possible to make an assumption about the activity of the angiogenesis system in the patient and assess the degree of its activity. AIM: To evaluate the activity of neoangiogenesis in the postoperative period in patients with obliterating atherosclerosis of the arteries of the lower extremities. MATERIALS AND METHODS: The study included data from 40 patients with obliterating atherosclerosis, who had a clinic picture of critical ischemia of the lower extremities, who underwent direct open revascularization operations. The content of HIF1a, VEGF and PDGF was evaluated in the pre- and early postoperative periods, and further during 1 year of monitoring. RESULTS: The HIF1a index from the initial 0.52 ng/ml in the early postoperative period decreased to 0.381 ng/ml (decrease by 27%, p = 0.004), in 1 month and 6 months of monitoring its concentration practically did not change (0.41 ng/ml in 1 month (p = 0.004), 0.398 ng/ml by 6 months (p = 0.003)), and the tendency to recovery was outlined only by 1 year of monitoring (0.495 ng/ml). The concentration of VEGF was initially 728 pg/ml, the decrease in its concentration was observed more smoothly and reached a minimum by 1 month of monitoring (552.2 pg/ml for 5–7 days and 480.7 pg/ml by 1 month (p = 0.025)). Further, during the monitoring, the concentration of VEGF increased by 6 months (529.8 pg/ml) and by 1 year of monitoring (515 pg/ml). Initially PDGF was 3563.8 pg/ml, and the most marked decrease in its concentration to 2922.5 pg/ml was observed already on the 5th–7th days after surgery (p = 0.043). Then the concentration of PDGF increased by 1 month of monitoring (3254.3 pg/ml) and remained at the same level (3270 pg/ml by 1 year), still not reaching the initial preoperative values. CONCLUSION: The maximum decrease in the concentration of proangiogenic factors was detected in the early postoperative period, which indicates a low activity of angiogenesis in this time interval and is the optimal time target point for the use of therapeutic angiogenesis techniques.
Modern Aspects of the Participation of Interleukin-1 Beta and Interleukin-6 in the Regeneration and Metabolic Processes of Bone Tissue (Literature Review)
Authors:   Chita State Medical Academy, Starosel’nikov Artem N. , Gusev Kirill A. ,   Chita State Medical Academy, Mironova Ol’ga B. ,   Chita State Medical Academy, Miromanov Aleksandr M. ,   Chita State Medical Academy
Published: October 2023

INTRODUCTION: Despite the enormous achievements of the world science in the field under the discussion, there are still many unconsidered points in the mechanism of the above-mentioned phenomenon, which, of course, requires work in this direction. It seems relevant to identify modern aspects concerning the role of interleukin-1 beta (IL-1β) and interleukin-6 (IL-6) in physiological regeneration, reparative regeneration and metabolic processes of bone tissue at the present stage of world scientific development. The search for literary sources was carried out in the open electronic databases of scientific literature PubMed and eLibrary. The search depth is 10 years.The review analyzes the world literature data on the current state of the issue of studying the action mechanisms of IL-1 beta and IL-6 on metabolic processes, physiological regeneration, reparative regeneration of bone tissue, including the mechanisms of the development of bone regeneration disorders in fractures. CONCLUSION: A huge number of factors related to various levels of homeostasis take part in the processes of metabolism, physiological regeneration, and reparative regeneration of bone tissue. Undoubtedly, in modern scientific society it is believed that IL-6, as well as IL-1ß, have an osteoresorptive effect, this fact is reflected both in injuries of bone structures and surrounding tissues, and in various diseases of the musculoskeletal system. Since, at the very beginning of the reparative regeneration of bone tissue, osteoresorptive processes prevail, it should be concluded that the aforementioned cytokines are among the first and main ‘conductors’ of bone tissue repair.
UPAYA PENERAPAN EKOSIDA SEBAGAI KEJAHATAN LUAR BIASA DI INDONESIA
Authors: Muhammad Ali Ausath
Published: October 2023

ABSTRAK

Lingkungan merupakan faktor penting dalam hidup manusia, namun sayangnya banyak perilaku manusia yang membawa kerusakan bagi lingkungannya sendiri. Bahkan beberapa kasus kerusakan yang disebabkan oleh manusia mengakibatkan musnahnya suatu ekosistem. Hal tersebut kemudian memunculkan istilah baru yaitu, ekosida. Ekosida merupakan kejahatan yang berdampak pada lingkungan dan bersifat masif, meluas, serta struktural yang jika dilakukan maka dapat merusak kualitas hidup manusia hingga menyebabkan kematian massal. Dampaknya yang luar biasa, ekosida kemudian diusung untuk menjadi salah satu jenis kejahatan luar biasa (extraordinary crime). Tujuan dari tulisan ini untuk memberikan penjelasan tentang perkembangan ekosida sebagai kejahatan luar biasa di dunia internasional dan melihat bagaimana upaya penerapannya di Indonesia. Penerapan ini menjadi penting karena penerapan ekosida menjadi kejahatan luar biasa merupakan agenda penting untuk melestarikan lingkungan hidup karena melihat kenyataan bahwa lingkungan hidup di Indonesia kondisinya semakin memprihatinkan. Penelitian ini menggunakan metode yuridis normatif yang menekankan pada studi law in book. Penelitian ini kemudian menyimpulkan bahwa ekosida perlu lebih diperhatikan dampaknya oleh masyarakat dan perlu adanya pengaturan khusus tentang ekosida dan menjadikannya sebagai kejahatan luar biasa.

Kata kunci: Ekosida; Kejahatan Luar Biasa; Lingkungan.

ABSTRACT

The environment is an important factor in human life, but unfortunately many human behaviors bring damage to their own environment. Even some cases of damage caused by humans result in the destruction of an ecosystem. This then gave rise to a new term, namely, ecocide. Ecocide is a crime that has an impact on the environment and is massive, widespread, and structural in nature that, if carried out, can damage the quality of human life to cause mass death. The impact is extraordinary, ecocide is then carried to become one of the types of extraordinary crimes. The purpose of this paper is to provide an explanation of the development of ecocide as an extraordinary crime in the international world and see how efforts are implemented in Indonesia. This application is important because the application of ecocide to be an extraordinary crime is an important agenda to preserve the environment because it sees the fact that the environment in Indonesia is increasingly poor. This research uses normative juridical methods that emphasize law in book studies. This research then concluded that ecocide needs to be paid more attention to its impact by society and there needs to be a special regulation of ecocide and make it an extraordinary crime.

Keywords: Ecocide; Environmental; Extraordinary Crime.
KERJA SAMA INTERNASIONAL DALAM MENGATASI KEPUNAHAN FLORA FAUNA DIKAITKAN DENGAN DEKLARASI STOCKHOLM 1972
Authors: Syukur Amalia Nurfitria , Fautngiljanan Johrdan
Published: October 2023

ABSTRAK

Peristiwa punahnya flora dan fauna yang marak terjadi belakangan ini, telah menunjukkan suatu  ketimpangan antara pelaksanaan penegakan hukum dengan pengaturan yang ada, khususnya di dalam sistem hukum lingkungan internasional. Secara global, terdapat dua bentuk kerja sama yang dapat dilakukan untuk mengatasi kepunahan flora dan fauna, yaitu kerja sama melalui perjanjian internasional dan kerja sama melalui organisasi internasional. Dalam hal ini, terdapat prinsip-prinsip dasar dalam Deklarasi Stockholm yang mengatur terkait perlindungan flora dan fauna. Prinsip kedua dan prinsip keempat Deklarasi Stockholm merupakan landasan hukum pertama yang mengatur mengenai sustainable use. Penelitian ini secara khusus akan membahas prinsip dalam Deklarasi Stockholm sebagai dasar perlindungan terhadap flora dan fauna. Tujuan penelitian ini adalah menganalisis dan mengkaji  instrumen-instrumen hukum lingkungan internasional terhadap perlindungan flora dan fauna. Metode yang digunakan dalam penelitian ini adalah deskriptif analisis dengan pendekatan normatif dengan data yang diperoleh dari penelitian kepustakaan. Hasil penelitian ini adalah prinsip kedua dan keempat Deklarasi Stockholm melahirkan kerjasama-kerjasama internasional melalui perjanjian internasional dan organisasi internasional, tetapi adanya kerjasama-kerjasama ini harus dibarengi dengan itikad baik dari masyarakat internasional.

ABSTRACT

The extinction of flora and fauna that is happening today has shown a disparity between implementation of law enforcement and the regulation, especially in international environmental law system. There are two forms of cooperation that can be carried out to overcome the extinction of flora and fauna namely cooperation through international agreements and cooperation through international organizations. In this case, there are basic principles in the Stockholm Declaration which regulates the protection of flora and fauna. The second and fourth principles of the Stockholm Declaration are the first legal basis which regulates about sustainable use. This study specifically discusses the principles in the Stockholm Declaration as the basis for the protection of flora and fauna.  The purpose of this study is to analyze and examine international environmental law instruments for the protection of flora and fauna. The method used in this research is descriptive analysis with a normative approach, with data obtained from literature study. This study shows that the second and fourth principles of the Stockholm Declaration have resulted in several international cooperations through international agreements and international organizations, but the existence of such cooperation must be accompanied by good faith from the international community.
PERLINDUNGAN HUKUM TERHADAP PEMILIK HAK ATAS TANAH BELUM TERDAFTAR YANG DIRUGIKAN AKIBAT MALADMINISTRASI PERANGKAT PEMERINTAHAN DESA
Authors: Adzannya Basuki Siti Hatia , Pujiwati Yani , Zamil Yusuf Saeful
Published: October 2023

ABSTRAK

Pemerintahan Desa berperan memberi pelayanan kepada masyarakat yang hendak mendaftarkan tanah untuk pertama kali dengan menyediakan bukti permulaan berupa salinan letter C. Penelitian ini mengkaji bagaimana perlindungan hukum bagi pemilik hak atas tanah belum terdaftar atas mal administrasi Pemerintah Desa, juga bagaimana tanggung jawab Pemerintah Desa dalam hal terjadi mal administrasi letter C sehingga menimbulkan kerugian bagi pemilik hak atas tanah belum terdaftar. Penelitian ini dilakukan dengan menggunakan metode pendekatan yuridis normatif. Spesifikasi penelitian bersifat deskriptif analitis, kemudian dianalisis secara kualitatif. Secara teoritis tidak ada perlindungan hukum bagi pemilik hak atas tanah belum terdaftar karena pada prinsipnya pendaftaran tanah yang diatur dalam perundang-undangan bertujuan untuk memberikan perlindungan hukum dan menciptakan kepastian hukum, namun pada praktiknya pemilik hak atas tanah yang merasa haknya terlanggar dapat mengajukan keberatan ataupun gugatan, dan Pemerintah Desa yang terbukti melakukan mal administrasi dapat dikenai sanksi jabatan yang ditetapkan oleh Bupati.

Kata kunci: Mal administrasi; Pemerintahan Desa; Pendaftaran Tanah.

ABSTRACT

The Village Government provides services to those who want to register land for the first time by providing initial evidence in the form of a copy of letter C. This study examines how legal protection for owners of land rights has not been registered for maladministration of village government apparatus, as well as how the responsibility of the village government in the event of maladministration letter C resulting in losses for owners of land rights that have not been registered. This research was conducted using a normative juridical approach. The research specifications are descriptive analytical, then qualitatively analyzed. Theoretically there is no legal protection for owners of unregistered land rights. However, in practice, land rights owners who feel their rights have been violated can file an objection or lawsuit, and the village government proven to have committed maladministration may be subject to office sanctions determined by the Regent.

Keywords: Maladministration; Village Government; Land Registration.
Penerapan internet of things pada smart parking system untuk kebutuhan pengembangan smart city
Authors: Koten George Reynaldi , Probodinanti Hesti , Tamba Johanes Daulat , Saputri Marshanda Krisnawi , Kwa Stelly Alison , Hadisantono  , Dewa Parama Kartika
Published: October 2023

Perkembangan zaman membuat kemajuan teknologi semakin pesat sehingga membuat manusia tidak terlepas dengan teknologi. Internet of Things (IoT) merupakan salah satu penerapan teknologi untuk memenuhi kebutuhan manusia dengan pemanfaatan konektivitas internet. Kendaraan sebagai kebutuhan sekunder manusia membutuhkan tempat parkir yang dapat memberikan rasa aman dan nyaman. Penelitian ini bertujuan untuk mengatasi permasalahan pengguna dalam mencari tempat parkir dengan menciptakan smart parking system. Studi kasus dilakukan di sebuah mall. Penelitian diawali dengan identifikasi permasalahan, kemudian merancang solusi, pengumpulan data yang relevan, serta perancangan dan pengkodean sistem. Smart parking system yang dirancang menggunakan sensor light dependent resistor (LDR) serta kamera automatic number plate recognition (ANPR)  dan lampu liquid-crystal display (LCD) sebagai alat yang dapat dengan mudah memberikan informasi yang kemudian ditransfer ke pengontrol. Kendaraan yang masuk ke dalam sistem harus teridentifikasi dengan memanfaatkan quick response (QR) Code. Melalui smart parking system, pengemudi akan mendapatkan kemudahan menemukan tempat parkir kosong dengan lokasi terdekat, metode pembayaran yang mudah, serta keamanan yang terjamin karena terhubung dengan aplikasi pengguna.
Coğrafi İşaret İle Tescil Edilmiş Antep Baklavasının Turistik Destinasyon Tanıtımına Yönelik Etkisi
Authors: Taş Nurdane , Düzgün Mehmet , Olcay Atınç
Published: October 2023

Türkiye'de coğrafi işaretli ürün sayısı her geçen gün artmaktadır. Avrupa Birliği nezdinde ülkemizin coğrafi işaret tescili alan ilk ürünü Antep baklavasıdır. Yapılan bu araştırmanın temel amacını Antep baklavasının destinasyon tanıtımı üzerindeki etkisinin ortaya konulması oluşturmaktadır. Gerçekleştirilen bu araştırma nitel desende tasarlanmıştır. Bu kapsamda öncelikle verilerin toplanması amacı ile literatür araştırması yapılmış, bu doğrultuda yarı yapılandırılmış bir görüşme formu hazırlanmıştır. Araştırma verilerine ise söz konusu yarı yapılandırılmış görüşme formu aracılığı ile Gaziantep’te yaşayan sekiz katılımcı üzerinden ulaşılmıştır. Elde edilen veriler MAXQDA 2022 programında analiz edilerek çözümlenmiştir. Ulaşılan sonuçlara göre Antep baklavası turizm faaliyetlerine çeşitlilik katması ve yerel ürünlerin turizme kazandırılması bakımından bölgenin tanıtımına büyük oranda katkı sağlamaktadır.
О защите пассажира в автомобильных ДТП.
Authors: Юскаев Юрий , Раевская Лариса
Published: October 2023

Современные автомобили имеют множество различных систем и устройств. В данной статье речь пойдет о вопросах касающихся автомобильной безопасности. В частности о новой разработанной авторами в нескольких вариантах переносной подушке безопасности автомобиля а также о некоторых недостатках существующих ПБ
Application Failure Mode Effect Analysis for Risk Management in New Costumer Acceptance Project in Garment Industry with approaching Project Management Body of Knowledge
Authors: Rahmawati Diah , Redi A.A.N. Perwira
Published: October 2023

Purpose: This research aims to identify risks at the time of fulfillment of the requirements set by the customer and determine their mitigation.

 

Method: In order to achieve the goal, researchers use the PMBOK approach that focuses on risk management by creating WBS and RBS. From the existing risks assessed using the FMEA method by conducting a survey to get the S, O and D values then calculating the RPN. 

 

Result: the highest RPN value in this study is 330 at risk 5.2. The understanding of PIC system and procedures in making the system, based on the result of brainstorming is decided that the mitigation is recruiting employee who is experienced in applying BSCI and factory evaluation audits due to the unavailability of employees who will become PIC compliance.
Study of the rheological properties of minced fish from aquaculture objects
Authors: Fatykhov Yuri Adgamovich , Alshevsky Dmitriy Leonidovich , Ustich Vladimir , Korzhavina Yuliya Nikolaevna , Veremey Elena Evgenievna
Published: October 2023

The paper dwells on the prospects of using the methods of extrusion processing of products based on minced fish. It is noted that one of the promising methods is the method of cold extrusion and co-extrusion. The research aims to identify theoretical and experimental patterns of changes in the rheological characteristics of minced aquaculture fish (carp and silver carp) and analyze them in relation to extrusion processes. The dependences of the rheological characteristics of minced fish samples on the influencing parameters in a wide temperature range from –5 to +25 °C have been studied. The values of the ultimate shear stress and the penetration depth of minced fish have been determined on a conical plastometer KP-3, viscosity – on a rotational viscometer Brookfield DV–II+Pro, and adhesive ability – on a laboratory unit for determining the stickiness of the material. Based on the data of minced fish chemical composition theoretical dependences of the effective viscosity on the shear rate gradient have been obtained. Similar dependences have been obtained experimentally in a wide temperature range. The analysis of these dependencies has shown their qualitative coincidence for the usual conditions for producing minced fish, but there are quantitative differences due to the technology for preparing minced aquaculture fish. The rheological characteristics of minced fish have been analyzed for the studied temperature range. It has been determined that the temperature range from –2.5 to 0 °C is the most appropriate for cold extrusion processes. In this area the value of the effective viscosity of minced fish and its adhesive ability are minimal, which is decisive for implementing extrusion processing. The good formability of the product has also been noted under these conditions. A further research direction is to identify the influence of technological additives on the formability of minced aquaculture fish, to reduce the smell of fish, and to eliminate undesirable oxidative processes. Developing new types of fish products with innovations in form, texture, colour and composition remains relevant. The prospects of the co-extrusion method which allows creating new innovative fish products with functional properties have been confirmed.