bluuebunny/crossref_metadata_2025 huggingface dataset:
Pathogenetic role of cytokines in hemorrhagic fever with renal syndrome in dynamics and disease of various severity
Authors: Ivanov Mikhail F. , Balmasova Irina P.
Published: July 2023

The aim of the work is to determine the relationship between the levels of cytokines of proinflammatory and anti-inflammatory action during the clinical course of hemorrhagic fever with renal syndrome (HFRS) and the previously described characteristics of the phenotypic composition of blood lymphocytes in disease of various severity.
Materials and methods. 65 patients with a serologically verified diagnosis of HFRS were under observation. The control group included 15 conditionally healthy people. Determination of cytokines in the blood of patients with HFRS was carried out by the enzyme immunoassay method at the different stages of the disease. The phenotypic composition of blood lymphocytes was assessed by flow cytofluorimetry.
Results. At the different stages of the disease, there was a quantitatively different increase in the content of cytokines in the blood associated with cytotoxic immune reactions (IL-12, IFN, TNFa, TNF), as well as IL-10 and IL-6 correlated with each other in severe cases, against the background of a drop in blood levels of IL-4 and IL-1. In the moderate course of HFRS, correlations of IL-12 and IL-4 with NKG2D+ CTL, the relationship of IL-12 with almost all other cytokines, and the correlation of CD8+ Treg with IL-6 and TNF levels were observed. In severe cases, the formation of a complex that included interconnected IL-6 and IL-10 correlating with the number of NKG2D+ CTL, CD8+ Treg, NKT was noted.
Conclusion. The pathogenetically significant mechanism of HFRS is realized with the predominant participation of cytokines of the cellular immune response and IL-6, correlatively associated with NKG2D+ CTL, CD8+ Treg, NKT, which, in case of a favorable outcome, contribute to the active formation of a pool of CD8+ memory cells, disrupted presumably by excessive secretion of IL-10.
In silico analysis of genomes of Bacillus anthracis strains belonging to major genetic lineages
Authors: Eremenko Evgeny I. , Pechkovskii Grigorii A. , Ryazanova Alla G. , Pisarenko Sergey V. , Kovalev Dmitry A. , Aksenova Lyudmila Yu. , Semenova Ol’ga V. , Kulichenko Alexander N.
Published: July 2023

Introduction. The global phylogenetic population structure of Bacillus anthracis is represented by major genetic lineages (A, B and C) with nonuniform distribution of isolates, which still cannot be explained. Identification of characteristics of genomes of strains from three lineages, which can affect their spread, is of high importance.
The aim of the study is to explore genomic characteristics of different genetic lineages, which may have an effect on their distribution, by using the in silico analysis of a representative subset of B. anthracis strains.
Materials and methods. The whole-genome sequences of 49 B. anthracis strains and Bacillus cereus biovar anthracis CI strain were studied. The in silico analysis was performed to identify polymorphisms using BLASTn, MEGA X, Tandem Repeat Finder, Parsnp the Harvest Suite software.
Results. The genome variability depended on single nucleotide polymorphisms, single-nucleotide repeats, number of tandem repeats, substitutions and indels. In strains from lineages B and C, they outnumbered 1.613.4 times and in the B. cereus biovar anthracis strain 5150 times those in B. anthracis strains from lineage A. Significant substitutions in housekeeping genes and pathogenicity factor genes caused changes in amino acid sequences in proteins significantly more frequently in B. anthracis strains from major lineages B and C.
Based on the molecular typing and a multi-virulence-locus sequence typing analysis (MVLST) with a discrimination index of 0.9633, strains were classified into three major genetic lineages including groups different from the canonical group.
Conclusion. The distinctive feature of B. anthracis genomes is that they have a larger number of significant nucleotide substitutions in pathogenicity factor genes and housekeeping genes of strains belonging to major lineages B and C compared to lineage A. Changes in proteins encoded by them can cause differences in ecological adaptation and in prevalence, which are higher in strains of lineage A. MVLST having a high discriminating capacity can be used as an additional method to B. anthracis molecular typing.
The state of specific immunity of population of the Republic of Tajikistan to measles, rubella, poliomyelitis viruses
Authors: Tsvirkun Olga V. , Tikhonova Nina T. , Turaeva Natalya V. , Tishkova Farida Kh. , Ruziev Murodali M. , Saidzoda Fayluli B. , Karpova Eugenia V. , Ivanova Olga E. , Kozlovskaya Liubov I.
Published: July 2023

Relevance. To achieve the goals of measles and rubella elimination and poliomyelitis eradication programs, immunization coverage of at least 95% of the target population is required. Objective data on the state of specific herd immunity are provided only by the results of serosurveys. In the Republic of Tajikistan, such monitoring is not carried out regularly. Therefore, the purpose of the study was to assess the actual state of the specific herd immunity to measles, rubella, and poliomyelitis viruses.
Materials and methods. The blood sera of 563 children and adults collected in 7 cities and 13 districts of Tajikistan in 2020 were investigated. The level of antibodies (ABs) to measles and rubella viruses was determined using enzyme immunoassay. Test systems VectoKor-IgG (VECTOR-BEST, Russia) and Ecolab, Russia were used to determine ABs to measles and rubella virus, respectively. Neutralizing antibodies (nABs) to the 3 types of poliovirus (PV) were determined in 359 sera using a neutralization reaction with Sabin strains of types 1, 2, 3.
Results. The conducted serosurvey showed the level of the specific herd immunity to rubella to be 87.9% in total population, including 86.2% in children, 93.1% in adolescents, and 93.5% and adults, that is sufficient to prevent transmission of the rubella virus. The proportion of individuals seropositive to measles was 54.5%, which is not enough to prevent sustained secondary transmission of infection and the resumption of circulation of the endemic strain of measles virus. The children under 15 years of age should be considered a population at risk of the infection, since children accounted for 38% among seronegative individuals.
In general, less than 95% of the examined patients had nABs to PV: 94.4% to PV1, 86.1% to PV2, 83.6% to PV3; 3.3% did not have antibodies to all three types of PV. The level of herd immunity varied in the examined groups depending on the vaccination schedule and the composition of the poliovirus vaccines used: nABs to PV2 had 59.6% of children born during the period when vaccines containing PV2 were not used, and 85.7% of children born after the introduction of trivalent IPV. Deficiency in immunity to PV2 was the cause of a polio outbreak in 2021 caused by circulating vaccine-derived PV type 2.
Conclusion. A high level of humoral immunity to the rubella virus was determined. Shortcomings of routine immunization against measles and polio associated with insufficient coverage and lack of IPV have been identified. Conducting regular serological monitoring in the Republic of Tajikistan is advisable to obtain objective information about the level of herd immunity, identify vulnerable groups of the population, and plan additional immunization activities.
Live attenuated COVID-19 vaccines: approaches to development and prospects for clinical use
Authors: Korchevaya Ekaterina R. , Gracheva Anastasiia V. , Dyakov Ilya N. , Zverev Зверев V. , Faizuloev Evgeny B.
Published: July 2023

Although WHO declared an end to the pandemic, COVID-19 remains a significant public health concern worldwide. Modern vaccines often induce either only humoral or only cellular immunity. Furthermore, new emergent epidemiologically significant SARS-CoV-2 variants and their spread considerably reduce the effectiveness of preventive vaccination. Therefore, there is an urgent need to improve the existing vaccines against COVID-19. One of the promising approaches to the solution of the problem is creation of a "universal" vaccine that would have a cross-protective activity against different antigenic variants of the virus. In this respect, the development of live attenuated vaccine is of special interest, as it can activate not only humoral, but also cell-mediated components of immunity, providing long-term immune response and cross-protection against different variants of the virus.
This review highlights the existing approaches to producing attenuated SARS-CoV-2 strains and gives an assessment of their prospects for clinical use. Some researchers use methods of genetic engineering and reverse genetics such as site-directed mutagenesis and codon deoptimization for virus attenuation. Others tend to use traditional approaches focusing on producing virus mutants through extended passaging in cell culture under selective conditions. The gained experience demonstrates great prospects for development of highly effective live-attenuated vaccine against COVID-19.
Deposizioni
Authors: Sassoli David , Martins Guilherme d’Oliveira , Faria Sandra Teixeira de , Colom Jiménez María
Published: July 2023

The statements here presented represent a tribute to David Sassoli and to the European values defended by Sassoli in his discours on the Future of Europe here included.
La solidarietà tra i popoli e gli Stati d’Europa come base della «costruzione europea»
Authors: Gonçalves Renato
Published: July 2023

Starting with the reflection on solidarity as the true and concrete element of the European Union, this article aims to reflect on the solidarity between people and states of Europe as the basis of the European construction.
«Amerai il prossimo come te stesso»
Authors: Leão Isabel Ponce de
Published: July 2023

You will love the next as you love yourself was the motto of life and work of David Sassoli, born communicator, who understanded that thought art we fight for any United and democratic Europe who innovates, protects and enlights. Six plastic artist understood his message and translated into different languages prolonging his plea.
PENGARUH BERMAIN PERAN PADA PENGENDALIAN DIRI SISWA
Authors: Hadi Gunawan Sakti
Published: July 2023

Bermain peran adalah salah satu model pembelajaran interaksi sosial yang menyediakan kesempatan kepada murid untuk melakukan kegiatan-kegiatan belajar secara aktif dengan personalisasi sehingga siswa dapat membantu dirinya dalam pengembangan diri seperti ikut merasakan apa yang dirasakan orang lain untuk menumbuhkan kontrol diri. Rumusan masalah penelitian ini adalah “Apakah Ada Pengaruh Teknik Bermain peran Pada Pengendalian Diri Dalam Penggunaan Media Sosial Pada Siswa Kelas VIII SMPN 1 Sakra Timur Tahun Pelajaran 2021/2022”. Tujuan penelitian adalah “Ingin Mengetahui Bermain peran Pada Pengendalian Diri Dalam Penggunaan Media Sosial Pada Siswa Kelas VIII Tahun Pelajaran 2021/2022”. Teknik Sampling yang digunakan dalam penelitian ini adalah Purposive Randem Sampling. Populasi dalam penelitian ini adalah 145 siswa, sample yang digunakan adalah 12 orang siswa. Metode pengumpulan data yang digunakan adalah metode angket sebagai metode pokok dan metode observasi, wawancara serta dokumentasi sebagai metode pelengkap. Untuk menganalisis data menggunakan rumus t-test, berdasarkan analisis data t hitung sebesar 8,260 dengan nilai t tabel pada taraf signifikansi 5% dengan db (N-1) = 11 sebesar 2,201. Dengan demikian nilai t hitung lebih besar daripada nilai t pada tabel (8,260>2,201), sehingga dapat di simpulkan Ada Pengaruh Bermain peran Pada Pengendalian Diri Dalam Penggunaan Media Sosial Pada Siswa Kelas VIII SMPN 1 Sakra Timur Tahun Pelajaran 2021/2022 dinyatakan Signifikan.
GAMBARAN KESIAPAN IBU DENGAN DUAL-CAREER MENJALANI MASA TRANSISI ANAK MENUJU SEKOLAH DASAR
Authors: Dewi Rayani
Published: July 2023

The transition period from childhood to elementary school is categorized as a transition period. This period requires special attention from various parties, both teachers, parents and schools. Parents have a major role, because with the readiness of parents to accompany children, children are easy to adapt and socialize in new environments. The respondents in this study were 3 mothers with dual carriers. Data analysis using interpretive phenomenological analysis. The results of the study show that there are two types of readiness, namely physical and psychological readiness. Physical readiness is described by a healthy physique, not stress two. While psychological is described by the ability of parents to manage emotions, be good listeners, always apply positive parenting patterns and use effective communication.
MENINGKATKAN PENGUASAAN KOSAKATA BAHASA INDONESIA MELALUI METODE SCRAMBLE PADA SISWA KELAS IV SDN 1 JERINGO TAHUN AJARAN 2021/2022
Authors: Atria Apriani  , Mujiburrahman
Published: July 2023

Latar belakang penelitian ini adalah banyaknya siswa yang mengalami kesulitan saat menjawab soal ujian mata pelajaran bahasa Indonesia karena tidak mengetahui arti kata atau istilah tertentu. Untuk itu, yang menjadi tujuan penelitian tindakan kelas ini adalah mendeskripsikan cara meningkatkan penguasaan kosakata bahasa Indonesia dengan menggunakan metode scramble pada siswa kelas IV SDN 1 Jeringo tahun ajaran 2021/2022. Hasil penelitian menunjukkan bahwa setelah pelaksanaan siklus I dan II dengan menggunakan metode scramble, nilai rata-rata kelas meningkat. Pada siklus I, nilai rata-rata kelas adalah 81,2 dengan jumlah siswa yang mendapat nilai standar minimal ke atas sebanyak 67,9%, sedangkan pada siklus II nilai rata-rata kelas meningkat menjadi 92,6 dengan jumlah siswa yang mendapat nilai standar minimal ke atas sebanyak 100%. Dengan demikian dapat disimpulkan bahwa penggunaan metode scramble sebagai salah satu upaya guru untuk meningkatkan penguasaan kosakata bahasa Indonesia siswa di kelas IV dinyatakan berhasil karena dapat memberikan hasil yang signifikan.
SEBUAH KAJIAN TEORI: IMPLEMENTASI PEER-ASSESSMENT UNTUK MENDORONG KEPATUHAN PESERTA DIDIK DALAM MELAKSANAKAN PROTOKOL KESEHATAN DI MASA PEMBELAJARAN TATAP MUKA TERBATAS (PTMT)
Authors: Siti Rabiatul Adawiyah
Published: July 2023

The limited face-to-face learning policy was taken by the Government because it saw that in general most regions in Indonesia had entered PPKM level 1 or the green zone, and 81% of education personnel had received vaccinations, even 72% of them had received dose 2 vaccination. The key to the success of limited face-to-face learning is the compliance of school residents with health protocols. This means that all school members, including students, are required to implement strict health protocols during the limited face-to-face learning process. One way that can be used to encourage and at the same time cultivate adherence to health protocols in the implementation of limited face-to-face learning, especially for students, is to implement peer-assessment to assess student compliance in implementing health protocols. This study aims to provide a theoretical study of the implementation of peer-assessment to encourage student compliance in implementing health protocols in the limited face-to-face learning period. This research is a library research (library research). Researchers obtain data by conducting literature reviews from various sources such as books, journals, scientific works, as well as documents and other relevant literature. Based on a review of several literatures, it can be concluded that the implementation of peer-assessment can be used to encourage student compliance in implementing health protocols, and can even help students to cultivate it in everyday life.
Evaluation of the cognitive and aesthetic dimensions in the cover designs of children's magazines
Authors: كاظم حاتم
Published: July 2023

Knowledge and beauty are intertwined variables, the first develops a sense of beauty and the second opens the mind to receive knowledge, and through them the human soul transcends to its highest outputs. For this purpose, the researcher deliberately linked and tracked these two dimensions for the purpose of exploring them in the designs of the covers of Al-Mizmar magazines for children issued by the Iraqi Child Culture House for the years (1979-1980-1981) and directed to the age group (9-12) years, and tried to subject them to a process of evaluation of the reality of their production in line with the seriousness Its impact on the culture of children due to the possibility of its access to their hands before the school age, i.e. before the textbook, then it has the role of increasing the delivery of ideas and information that should be sound according to the general perspective, for its distinctive role in gaining the child’s desire and generating a need for him to turn towards the magazine, which determines the importance of the research Present
Soviet expansion in the Baltic region 1939-1941
Authors: عبد علي عماد
Published: July 2023

Throughout its history, the Baltic states witnessed a great colonial competition between the major powers surrounding them, which greatly affected them. The political situation in the European continent, especially after the conclusion of the German-Soviet non-aggression pact on August 23, 1939.The annexation of the Baltic states to the Soviet Union is an example of the expansionist policy pursued by the Soviet Union in order to obtain new land through diplomatic pressure accompanied by the threat of using armed force. This expansion in the Baltic region has a long story that began with the end of World War I.
The role of means of communication in agricultural development (field study)
Authors: الخفاجي جاسب , سلطان حمزة
Published: July 2023

The way is still open for researchers to reach a conviction confirming the role of mass communication in the growth of societies, and all that is available at the present time are the views and positions of some researchers on this subject, and these positions and opinions depend on the professional and academic backgrounds of those who adopt them .. There are those who believe that communication The masses have no influence on the development process..while others see the exact opposite when this type of communication is combined with direct personal contact.
Exegetical schools fact or fiction
Authors: زوين محمد
Published: July 2023

It is not new to say that the limits of the terminology used to denote what it is often tend to metaphor on the one hand and to the generality on the other hand, so that then accuracy and scientific coherence become required in the academies, although the title must match the title.There is no doubt that logic and its origins have an impact on what is termed for the titles of science and the arts, and reasoning requires in the definition of each term the characteristic of plural and prohibition in its conception, that is, it collects the conditions, preventing the entry of what is not in it, and if you add to that the origins and roots, then the terms that have significance In laying down, setting and circulating terms, names took place and were organized according to their names.
Quality of Life and Age-Related Macular Degeneration
Authors: Elhaj J. Ait , Sbai K. , Hidan Y. , Mchachi A. , Benhmiddoune L. , Rachid R. , Elbelhadji M.
Published: July 2023

The aim was to measure the life quality of patients with age-related macular degeneration. The survey included patients with age-related macular degeneration, aged 65 years and older. Recruitment of participants was performed from the preoperative consultation at the adult ophthalmology department. Investigation sheets containing socio-demographic, clinical data and the Moroccan version of the NEI VFQ25 quality of life questionnaire; were handed out to each patient. The association of the scores with the visual acuity was studied using the correlation coefficients. A total of 75 patients were enrolled including 56% women and 44% men and an average time of 3 .6 years since diagnosis of age-related macular degeneration with a mean age of of 76.9 ± 6.2 years. Average visual acuity (VA) in the better eye is 6/10 and 2/10 in the worse eye. The mean global VFQ-25 score was 48.7 ± 24.8. The significant public health burden of AMD includes both its negative effects on quality of life and on the economy. AMD causes a marked decrease in quality of life, underestimated by many, including physicians who regularly treat patients with AMD.
Prevalence of Nephroblastoma in Children from 0 to 15 Years at Sikasso Hospital
Authors: Poma Hachimi Amadou , Maiga Djénéba , Keita Chaka , Samaké Magara , Berthé Fatoumata , Traoré Salif , Sanogo Abdoulaye , Touré Saidou , Dembélé Marie Ange , Dolo Aboudou , Ouattara Harouna , Doumbia Abdoul Karim
Published: July 2023

Introduction: Nephroblastoma or Wilms tumor is the most common renal tumor in children (90%) and accounts for 5- 10% of pediatric cancers. The WHO estimates the annual number of new cases of childhood cancer at 160,828. In Mali, nephroblastoma is the 3rd most common malignant disease in children after lymphoma and retinoblastoma. The main objective of this work is to study the frequency of renal tumors in children aged 0 to 5 years in the hospital of Sikasso. Method: This will be a retrospective, descriptive and analytical study of all cases of nephroblastoma diagnosed over a 5-year period from 2017 to 2021 at Sikasso Hospital. Result: The most represented age range was 3 -7 years. Male gender was the majority in 62.50% of cases, with a sex ratio of 1.7. All patients had an abdominal mass, a lumbar contact. Patients with a duration of symptom evolution between 1 and 2 months were in the majority in 50% of cases. The tumor was unilateral in 87.50% of cases. Lung abnormalities were present in only 12.50% of cases. Hematuria was found in 37.50% of cases. Left kidney tumor was the majority in 75.00% of cases. Conclusion: Nephroblastoma remains the most frequent renal tumor in children, however, the delay in diagnosis remains a major challenge.
Internal Carotid Artery Agenesis: A Rare Incidental Finding
Authors: Jelloul Sarah , Merzem Aicha , Bounnite Imane , Belgadir Hasna , Amriss Omar , Moussali Nadia , Benna Naima El
Published: July 2023

Internal carotid artery agenesis is a very rare anomaly, occurring during the early stages of embryonic development. We report the clinical presentation and imaging findings both on CT and MRI of the incidental finding of a left internal carotid agenesis in a 40 year old female. Magnetic resonance angiography was the most valuable diagnostic tool for the positive diagnosis, showing the absence of the left internal carotid artery, with left circulation arising from the right anterior cerebral artery and left posterior cerebral artery. Unenhanced computed tomography was used to differentiate between internal carotid agenesis and hypoplasia. Imaging should also look for associated malformations such as aneurysms as well as ischemic and hemorrhagic complications.
Bias of Investor Behavior in Making Investment Decisions in the Capital Market
Authors: Candraningrat Ica Rika , Abundanti Nyoman , Putri Putu Astriwira , Febyanti Ni Putu Reditha
Published: July 2023

Purpose: The long-term goal of this research is to find out the behavior of investors in making investment decisions in the capital market, while the specific target to be achieved is to know the biases of investor behavior in making investment decisions. Investment decision makers do not always behave in a way that is consistent with the assumptions made in accordance with the perception and understanding of the information received, but is strongly influenced by psychological factors. Research Methodology: This type of research is descriptive quantitative research. The survey was conducted on investors who are members of the group of young investors. The population of this study is all investors who actively trade in the Bali branch of the Indonesia Stock Exchange. By using a purposive sampling method, namely taking samples by adjusting the research criteria, namely investors who have made transactions in trading on the stock exchange for at least two years. Multiple regressions was used to test the hypotheses that were developed at a significance level of 0.05 percent. Results: Investors experience behavioral bias due to the influence of disposition and excessive trust. This circumstance will result in a reduction of their final wealth. The disposition effect influences decision making on investor behavior in the capital market. Investors have a tendency to realize less profits compared to the tendency to realize losses. Limitations: The results of this study may not apply to other excluded categories because this research is limited to investors who actively trade in the Bali branch of the Indonesia Stock Exchange. Contribution: Investors will be better off if they don't hold their shares for too long when the stock price declines and are not advised to sell profitable shares too quickly. Investor literacy should be improved by understanding information about company fundamentals.
ANALISIS MARAKNYA HIJAB BUTTONSCARVES
Authors: Arsj Febri Rakhmawati
Published: July 2023

Penelitian ini di latar belakangi dengan adanya fenomena perkembangan pelaku industri hijab fashion yang sedang marak tiga tahun belakangan ini yang menjadi sebuah gaya hidup dan trend. Pada penelitian ini mengkaji lebih dalam mengenai perempuan muslimah yang menggunakan hijab premium di kalangan masyarkat urban yang dikenal dengan sebutan BSLady sebagai pencinta dari hijab dengan brand Buttonscarves. Penelitian ini menggunakan metode deskriptif kualitatif dengan teknik pengumpulan data pada penelitian yakni melalui metode wawancara dan observasi ke tiga toko Buttonscarves di Jakarta seperti Plaza Indonesia, FX serta Senayan City sebagai lokasi penelitian. Peneliti dibantu oleh tujuh informan sebagai sumber informasi. Hasil penelitian menunjukkan bahwa Buttonscarves mengusung signature luxurious scarves dengan memberikan value added lifestyle/prestige yang menerapkan lifestyle marketing. Memiliki club pecinta Buttonscarves dengan sebutan BSLady, serta memilih lokasi toko yang selektif yang terletak di mall-mall besar di setiap kota besar di Indonesia dan Malaysia, melakukan kolaborasi dengan para selebgram serta dengan BUMN maskapai penerbangan Garuda Indonesia pada musim mudik lebaran 2022.
PENGEMBANGAN DESAIN MOTIF BATIK LAWAI MENGGUNAKAN APLIKASI DIGITAL
Authors: Aisah Siti , Sundari Susanti , Poningin Poningin , Prastio Yoga
Published: July 2023

Penelitian ini mengenai pengembangan desain motif batik Lawai (Lampung Wawai) dengan menggunakan aplikasi digital. Adapun tujuan dari kegiatan ini adalah sebagai salah satu upaya dari pengembangan desain batik Lampung dengan membuat suatu desain batik Lampung konsep baru yang memiliki ciri khas tersendiri dengan aplikasi digital.Metodologi yang digunakan dalam penelitian ini adalah perancangan desain yang meliputi beberapa tahapan yaitu observasi pada motif, pembuatan motif dan pembuatan desain. Hasil dari desain batik Lawai berisikan unsur motif yang diambil dari unsur kebudayaan Lampung, diantaranya motif siger, badik Lampung, payung adat, pasanganmerak yang menggunakan siger dan kopiah Lampung, durian, lapis legit, dan aksara Lampung. Pembuatan desain batik dengan konsep “Batik Lawai” bercirikan sebuah desain yang lebih ekspresif dan menggunakan imaginatif personal dengan menggunakan aplikasi IbisPaintX dan CorelPhotoPaint. Pengembangan desain batik Lawai ini merupakan salah satu upaya memajukan warisan budaya khususnya budaya Lampung, dan melestarikan kekayaan intelektual batik Indonesia.
PENGEMBANGAN KEUNGGULAN KOMPETITIF UMKM MELALUI STRATEGI ORIENTASI PASAR DAN INOVASI PRODUK
Authors: Ernawati Ernawati , Mardikaningsih Rahayu , Darmawan Didit , Sinambela Ella Anastasya
Published: July 2023

Setiap perusahaan yang berada dalam suatu industri dan menghadapi persaingan harus memiliki keunggulan kompetitif. Hal ini mutlak diperlukan tidak hanya bagi perusahaan besar tetapi juga perusahaan kecil dan menengah untuk menjamin kelangsungan usaha. Bisnis akan terus berjalan jika perusahaan berhasil menciptakan keunggulan bersaing. Ini adalah kunci penting untuk memenangkan persaingan. Studi ini berusaha mengamati peran kedua strategi tersebut dalam membentuk keunggulan bersaing. Kajian difokuskan pada UMKM alas kaki di Desa Wedoro, Sidoarjo, Kecamatan Waru, Kabupaten Sidoarjo. Dengan melibatkan beberapa pengusaha alas kaki sebagai sumber informasi untuk mencapai temuan penelitian ini. Berdasarkan hasil pengolahan data diketahui bahwa orientasi pasar dan inovasi produk memiliki peran yang nyata dalam membentuk keunggulan kompetitif.
PENGARUH KUALITAS PRODUK, BRAND IMAGE, DAN HARGA TERHADAP KEPUASAN KONSUMEN PADA BITTERSWEET BY NAJLA
Authors: Hidayani Novika , Arief Muhammad
Published: July 2023

Tujuan pada penelitian ini untuk mengetahui pengaruh kualitas produk, brand image dan harga terhadap kepuasan konsumen bittersweer by najla. Penelitian ini dilakukan kepada pembeli yang pernah membeli bittersweet by Najla sebanyak 200 responden. Penelitian menerapkan teknik purposive sampling. Pengumpulan data primer dilaksanakan melalui penyebaran kuesioner menggunakan google form. Teknik analisis data menerapkan regresi linear berganda dengan kepuasan konsumen sebagai variabel dependen, kualitas produk, brand image serta harga sebagai variabel independen. Hasil pada penelitian telah membuktikan variabel kualitas produk berkorelasi signifikan terhadap kepuasan konsumen, brand image berkorelasi signifikan terhadap kepuasan konsumen, harga tidak berkorelasi signifikan terhadap kepuasan konsumen serta kualitas produk, brand image serta harga memiliki pengaruh secara simultan terhadap kepuasan konsumen.
STRATEGI PENGEMBANGAN PASAR TRADISIONAL PADA PASAR GUNTUR CIAWITALI GARUT
Authors: Muharam Husni , Susilawati Wati , Sarofah Siti
Published: July 2023

Pasar tradisional merupakan tempat terjadinya hubungan atau interaksi antar orang yang melakukan jual beli. Salah satu mata pencaharian masyarakat Garut yang perlu perhatian dari pemerintah adalah di Pasar Tradisional. Salah satu pasar terbesar yang merupakan pasar induk yang ada di Garut adalah Pasar Guntur Ciawitali dengan jumlah kios dan los jalur 3.085 untuk tahun 2020. Tujuan dari penelitian ini adalah untuk mengetahui kondisi internal dan eksternal dari Pasar Guntur Ciawitali Garut dan untuk mengetahui strategi yang menjadi upaya pengembangan Pasar Guntur Ciawitali Garut. Metode penelitian yang digunakan pada penelitian ini adalah metode kualitatif dengan penentuan informan secara purposive sampling sebanyak 5 orang dan narasumber 1 orang. Analisis data yang digunakan adalah analisis SWOT dan AHP (Analytic Hierarchy Process). Hasil dari penelitian ini adalah bahwa faktor eksternal dan faktor internal memiliki pengaruh pada Pasar Guntur Ciawitali Garut yaitu faktor eksternal terdiri dari kekuatan pasar Guntur Ciawitali Garut terdiri dari lokasi yang strategis, target konsumen semua kalangan, masih terdapat budaya tawar menawar, terdapat upaya perbaikan pasar, produk yang variatif, dan harga produk yang dijual sangat murah.
Ibn Khaldun s Contribution to the Study of the Social Dynamics of International Relations
Authors: Fedayee Mohammad Javid
Published: July 2023

Bu makale, 14. yüzyılda yaşamış ünlü Müslüman tarihçi, filozof ve akademisyen İbn Haldun'un sosyal ve siyasi eserleri üzerine bir çalışmadır. Uluslararası ilişkilerin sosyal dinamikleri alanındaki görüşleri büyük beğeni toplamış ve günümüz akademisyenlerini hala etkilemektedir. İbn Haldun'un tarih metodu, sosyal kurumların ve insan davranışlarının tarihsel olguları nasıl şekillendirdiğini vurgulayan kendine özgü bir metottur. İbn Haldun'un ufuk açıcı eseri Mukaddime, özellikle uluslararası ilişkiler alanında insan davranışının döngüleri ve kalıpları ile toplumun evriminin kapsamlı bir incelemesini sunmuştur. İbn Haldun'un Asabiye, Umran, kırsal ve kentsel yaşam, devlet ve iktidar en etkileyici eserleridir ve Umran'ı evrensel bir medeniyet olarak kabul edilebilir. Onun kavramları, özellikle uluslararası ilişkilerde insan davranışının ve sosyal gelişimin karmaşıklığını anlamamıza hala yardımcı olmaktadır.
A Simple Approach to Overcoming Euro-Specific Feudalism
Authors: Eshete Ibrahim Mulushewa
Published: July 2023

Osmanlı toplumsal oluşumunun doğasına ilişkin tartışmalarda, 20. yüzyıl Türk tarihçilerinin çoğu bunun "feodal olmadığını" iddia etme eğilimindeydiler. Bunun Avrupa merkezciliğinin bilinçsizce ithal edilerek içselleştirmelerinden kaynaklandığını iddia edilmektedir. Bunun nedeni özellikle Avrupa'ya özgü bir feodalizm kavramını veya tanımını kıstas olarak kullanıyor olmalarıdır. Ayrıca cins ve tür arasında, özel ve genel arasında ayrım yapma konusundaki metodolojik, aslında felsefi bir başarısızlık da söz konusudur. Modernite öncesi tarım devletlerinin ve toplumlarının çoğunda ortak olan şey, bir tımar sisteminin varlığıdır. Ancak bir kraliyet güç merkezi, tımar dağıtımına başvurduğunda, farklı güç konfigürasyonları ortaya çıkabilir. Bu makalede önerilen, uygarlıkların ortak yapıları üzerine yakın zamanda tamamladığım doktora tezimden türetilen, taksonomiye yönelik bu revizyonist yaklaşımdır.
Exploring the Operational Framework of Child Welfare in Haryana - Issues and Challenges
Authors: Dr. Vinay Khurania  , Dr. Minu Singal  , Ch. Ishwar Singh
Published: July 2023

The concept of Child Welfare deals with the services and the institutions catering physical, social and psychological cover to the child (in need of care and protection), one of the most vulnerable section of society, facing various sufferings due to numerous reasons such as lack of parental care and supervision, poor financial resources and inadequate provision for education although the scope of child welfare is growing wider in developed nations. India is the world’s second most populous country and the share of the child population to that of the total is quite a big number. In India, every child has a right to lead a life with dignity. Moreover, the Constitution of India guarantees fundamental rights to every child implemented through directive principles of state policy. India has a comprehensive legal regime and policy framework to protect the rights and interests of the children, however, greater momentum is required for the effective implementation of these policies and programmes for the well-being of the children by improving their education and nutrition. Already a lot of work has been done by community partners, however, the results are not convincing. The present study is aimed to examine the functioning of the child welfare mechanism and its impact on beneficiaries especially focussed in the Haryana State.Keywords: child welfare, legislation, welfare machinery, beneficiaries.
Anticancer Activity of Turmeric Rhizome Extract (Curcuma longa Linn) In-vitro Against MCF7 Breast Cancer Line Cells
Authors: Halimatushadyah Ernie , Rahayu Ani
Published: July 2023

Turmeric or Curcuma longa Linn is one of the native spices and medicinal plants from Southeast Asia. Turmeric contains a compound named curcumin. Curcumin (diferuloylmethane) is a yellow pigment in turmeric that is widely used as a spice, food coloring (curry) and preservative. Curcumin shows various pharmacological effects that have been reported scientifically in research, one of which is as an anticancer. This study aims to perform a cytotoxic test of turmeric rhizome extract (Curcuma longa Linn) in-vitro with the Microtetrazolim (MTT) assay method to grasp and determine the effect of preventing the growth of MCF7 breast cancer cells, so that the IC50 value can be known. In this study, it was found that turmeric rhizome extract can be used as a natural ingredient that has the potential to inhibit the growth of MCF7 breast cancer cells. Turmeric rhizome extract has the effectiveness to inhibit the growth of MCF7 breast cancer cells with an IC50 value of 26.30 ppm. This value is categorized as moderate or moderately active cytotoxic.
Analisis Biaya Operasional Kendaraan Pada Perusahaan Pengurusan Jasa Kepabeanan
Authors: Elviana Rahmi , Nesti Lisa , Larici Reni Desweri
Published: July 2023

Entrepreneur Management Customs Services (PPJK) serves to assist importers or exporters in shipping goods. The indicators of PPJK services are customer satisfaction, timeliness, suitability of quantity and condition of delivery goods. Based on this, distribution is a very important component. Decision making for determining the type of vehicle that will be used to distribute goods requires a comparison between costs and the selection of an appropriate method for making these decisions. The purpose of this study was to analyze the operational costs of PPJK vehicles using Vehicle Operating Cost Analysis (BOK). The conclusion is that the company is advised to use its own delivery vehicle if it has a budget for the purchase of the vehicle. This is because the funds spent on rental costs are greater than operating costs. Based on the calculation of PPJK's Vehicle Operational Costs, the fixed cost of the vehicle is Rp. 325,429,472/year, variable vehicle costs of Rp. 115,579,320/year and other costs of Rp. 43,560,000/year. PPJK was declared eligible to invest in vehicles because the difference between the calculation of the operating costs of the vehicle itself and the rental amounted to Rp. 1,088,910,152, which means the rental cost is higher. In addition, the use of company vehicles can minimize risk factors for work accidents, costs, time and customer satisfaction as long as they have competent human resources.
Keywords: BOK, Entrepreneur Management Customs Services, PPJK
Analisis Terhadap Bimbingan Perkawinan Pra Nikah Dalam Mewujudkan Keluarga Sakinah, Mawaddah wa Rohmah Di Kantor Kementerian Agama Kota Lubuklinggau
Authors: Sukatno Sukatno , Yusefri Yusefri , Sumarto Sumarto
Published: July 2023

In general, premarital marriage guidance is carried out by the District Office of Religious Affairs, but the reality is different from Lubuklinggau, the implementation of marriage guidance is carried out at the Ministry of Religion Office. In addition, divorce in Lubuklinggau is quite high, ranging from 1,200 cases. This research is a qualitative research with a field research method and uses a statute approach or a law approach. This study concludes that, firstly, premarital marriage guidance at the Ministry of Religious Affairs Office of Lubuklinggau City was held quite well, that the participants who were guided did not include the total number of prospective brides who registered at KUA because it adjusted the Budget Dipa/RKA-KL and there were no other policies. The implementation is flawed because many informants have not been educated. The divorce that occurred in Lubuklinggau may be caused by other factors such as economic factors, social factors and so on.
Implementasi Pembelajaran di Era Revolusi Industri 4.0 di SMP Negeri 2 Lubuklinggau
Authors: Handayani Fitri , Arikarani Yesi , Mukmin Taufik , Akip Muhamad
Published: July 2023

The development of education is undergoing a rapid, dynamic transformation with technological advances in the era of the industrial revolution 4.0. This change is felt by the teaching and learning process at SMP Negeri 2 Lubuklinggau implementing 4.0-based learning in its application that has not been maximized and the existing technology is not used as well as possible. This study uses a qualitative approach with this type of research being field research, interview data collection techniques, observation and documentation. Analysis technique according to Miles and Humbersman. The findings of the first research, the implementation of PAI learning at SMP Negeri 2 Lubuklinggau still uses conventional methods, complete learning resources, delivering appropriate and clear material. Second, the efforts of teachers in the era of the industrial revolution 4.0 to master learning technology by using smartphones for online learning. Third, the supporters are facilities and infrastructure, internet network, focus, and learning resources. The obstacle is that students feel pampered by technology that is instant and easy to access, students are lazy to read in detail.
Pendidikan Ruhani Berbasis Kecerdasan Ruhiologi
Authors: Iskandar Iskandar
Published: July 2023

National education aims to increase faith, piety, and noble character, which is an aspect of the basic needs of all citizens, in the education process students should receive a strong educational formulation of religious values. This study aims to explore the formulation of national education attainment comprehensively and find new models, or postulates about the formulation of spiritual education based on spiritual intelligence in achieving the main educational goals, namely the achievement of the level of faith, piety and noble character of students. The research method uses descriptive qualitative research. Sources of data sourced from secondary data, namely library data, interview data and field data related to the topics we discussed. While the secondary data aims to support the main data. Data collection techniques collect relevant documents and conduct interviews with related subjects, while data analysis is through data collection, data reduction, data display, verification and data presentation. The results show that the achievement of national education goals in practice has not holistically developed the potential of students, but is more dominant in developing the nature of the mind including cognitive, affective, psychomotor with the Intellectual Quotient (IQ) paradigm approach, Emotional Quotient (EQ), Spiritual Quotient (SQ) so that the educational outcomes meet the legal formalities, while the behavior deviates from the educational outcomes that are not in line with the main national education goals, namely increasing faith, piety and noble character. This illustrates that the attention to the application of the spiritual education dimension of students based on transcendental philosophy is still not focused. Therefore, it is necessary to formulate transcendental-based spiritual education, namely Ruhiologi Quotient (RQ) to be understood by educators and students holistically to guide the IQ, EQ, SQ intelligence paradigm for the achievement of holistic educational goals.
КОНСТРУКЦІЙНЕ УДОСКОНАЛЕННЯ КОЛІСНОГО РУШІЯ ВІЙСЬКОВОГО АВТОМОБІЛЯ
Authors: Петров Л. , Кішянус І.
Published: July 2023

The movement of the car is carried out due to the loading of the wheel driver by forces: gravitational force and tangential force of traction, which sometimes leads to a delay in the movement of the rotation of the tire during its deformation, as well as to the incomplete realization of the power created by the engine and which is transmitted to the wheel driver. The article examines the questions and presents elements of the theory of a military vehicle with a structural improvement of the wheel drive of a military vehicle, as well as theorems on the change in kinetic energy of such a wheel drive.
The technological diagram of the developed and improved design of the wheel drive allows the process of transferring the motion of the car to be carried out at the expense of the kinematically-related movable additional wheel, the transformation of the energy supplied to the wheel drive into the controlled relative to the center of its hub and with the addition of the traction force of the car with the transfer force, which is an auxiliary factor to the innovative technology of its movement.
The scientific and practical direction of the work consists in the fact that for the first time the technology is considered in which the law of change of mechanical energy is applied during the rotation of the wheel drive on the road by using the wheel drive with an additional wheel kinematically connected to it.
The research methodology was to establish a mathematical relationship between the speed of the cyclic movement of the additional wheel, which is associated with the center of the car wheel hub, and this allows to increase the dynamic mobility of the car directly.
The result of the research is the development of elements of the theory of a military vehicle with a new design of a wheel drive with an additional wheel kinematically connected to it, which allows to increase the dynamic mobility of the vehicle directly. The value of the conducted research, the results of the conducted work will allow to make a contribution to the automotive industry.
The proposed model of a car with a new design of a wheel drive with an additional wheel kinematically associated with it is suitable for use in order to effectively realize the power of the engine and convert it into traction force on the wheel.
Keywords: physical-mathematical model, force, wheel drive with an additional wheel kinematically associated with it, wheel, gravitational and tangential force, moment of inertia, kinetic energy.
АНАЛІЗ МОЖЛИВОСТЕЙ ПРОТИДІЇ БЕЗПІЛОТНИМ ЛІТАЛЬНИМ АПАРАТАМ
Authors: Маміч В. , Галактіонов М. , Душкін Ю. , Чкалов А. , Цаприка Д.
Published: July 2023

This scientific work examines the main approaches to the modern classification of unmanned aerial vehicles. It was noted that in the zone of full-scale invasion in the east of Ukraine, Russian troops and private military companies of Russia use them to solve strategic, operational and tactical tasks. It was noted that with the development of modern technologies, it became possible to manufacture unmanned aerial vehicles with smaller dimensions, but with better capabilities for conducting constant reconnaissance, delivering massive surprise strikes using barrage ammunition, which made it much more difficult to fight them with air defense means and forces. All this is because traditional types of air defense weapons are designed to destroy large and distant targets, while modern drones consist of nano-, micro- and mini-devices flying at low and super low altitudes. Various means of destroying unmanned aerial vehicles were considered, a comparative analysis of modern countermeasures against unmanned aerial vehicles was carried out, and conclusions were drawn regarding the possibility of their comprehensive use in the Armed Forces of Ukraine. In this paper, an analysis of the possibilities of reducing the effectiveness of the use of unmanned aerial vehicles in the hybrid war waged by Russia in Ukraine today was carried out, the trends of the combat use of unmanned aerial vehicles in solving combat tasks in modern combat were revealed. This article also considers the possibilities of countering unmanned aerial vehicles that are controlled by an operator through control channels that are controlled automatically and with combined control. As a result of the conducted research, the possibilities for their destruction by various means of fire destruction were determined.
Keywords: unmanned aerial vehicles, analysis, hybrid warfare, countermeasures, classification, trends, effectiveness, combat tasks, operator, control channels, research.