bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation Method for Determining Rock Brittleness in Consideration of Plastic Deformation in Pre-Peak and Failure Energy in Post-Peak
Authors: Yue Xiaopeng , Wen Tao , Gao Yuan , Jia Wenjun , Wang Yankun , Hu Mingyi
Published: November 2023

The assessment of rock brittleness holds significant importance for understanding and predicting the mechanical properties and engineering behavior of rocks. Due to the lack of a unified definition of rock brittleness, numerous evaluation methods for brittleness indexes have been proposed by scholars both domestically and internationally in recent decades, resulting in diverse evaluation outcomes. In this study, we first summarize the existing rock brittleness evaluation methods and highlight their respective advantages and disadvantages. Subsequently, considering the pre-peak plastic deformation of the rock mass, the pre-peak brittleness index factor is introduced. Furthermore, taking into account the total energy consumed by the rock mass for failure after the peak, the post-peak brittleness index factor is proposed. These two components of the brittleness index describe the characteristics of different stages of the stress-strain curve, leading to the development of a novel brittleness index. The proposed method is then applied to evaluate the brittleness of both red-bed sandstone and cyan sandstone, revealing the variation of rock brittleness under different working conditions. Finally, three existing evaluation methods are selected to validate the rationality of the proposed method. The results demonstrate that for red-bed sandstone, the proposed brittleness index exhibits maximum values under natural conditions at all confining pressures. The four brittleness indexes consistently characterize the brittleness of red-bed sandstone under natural conditions. Under saturated conditions, the brittleness indexes exhibit different patterns of variation. For cyan sandstone, the three brittleness indexes—B7, B9, and Bnew—exhibit a similar trend in characterizing the brittleness of cyan sandstone under natural conditions and freezing-thawing conditions, while the trend of B17 is essentially opposite to that of the previous three indexes. The research findings provide guidance for the assessment of sandstone brittleness.
Design and Analysis for Multi-Layered Elastomeric Bearing on Rotor Hub Considering Large Axial Load and Nonlinear Motion
Authors: Jang Jun-Hwan , Ahn Sang-Ho
Published: November 2023

This paper examines the initial sizing theory of elastomeric bearings. In addition, the manufacturing process of the elastomeric bearing was analyzed to define the essential contents necessary to manufacture reliable elastomeric bearings. Mooney-Rivlin parameters were presented based on the test results to predict the characteristics of metal materials and rubber stacked. Mooney-Rivlin parameters were inputted to determine whether the structure was abnormal, by constructing a finite element model for the elastomeric bearing. A modeling technique was established to meet the structural rigidity and strength requirements of full elastomeric bearings, critical components of the helicopter main rotor system. In addition, the flight situation in which the maximum load of an actual helicopter equipped with an elastomeric bearing can be applied was selected, and linear structural analysis and nonlinear analysis were performed to confirm the behavior of the elastomeric bearing. As a result of performing linear static analysis, a negative margin was generated, but when nonlinear analysis was performed again, it was confirmed that there was a sufficient safety margin. It was shown that design reliability for the molding and manufacturing process of elastomeric bearings could be improved in terms of strength.
Microwave-Supported Modulation of Functional Characteristics of Gluten-Free Breads
Authors: Lisovska Tetiana , Tyupova Alona , Olędzki Remigiusz , Harasym Joanna
Published: November 2023

Currently, the market for gluten-free products is experiencing a significant growth due to, mainly, the increase in the number of gluten-intolerant patients diagnosed and to the merging of a new niche market for consumers who optionally avoid gluten. Native flours are perceived as viable alternatives for industrially used starch and hydrocolloids blends, which lack in the vitamins and minerals that are in abundance in non-refined raw materials. This study delves into the potential of microwave technology in enhancing the functional and nutritional attributes of gluten-free breads. The research was conducted by employing 900 W microwave power for 8 min for buckwheat and teff flours modification with an initial moisture content of 30%. The modified flours were blended with rice flour and baked to verify the potential of microwave high moisture treatment for adjusting the texture and nutritional quality of the bread. The results revealed that microwave treatment of flours helped in retaining a higher level of essential nutrients and bioactive compounds in gluten-free breads.
Research on Lateral Deformation Control Criteria of Metro Shield Tunnels with Excessive Ellipticity
Authors: Kan Shaode , Chen Junsheng , Liang Yuehua , Wang Yizhao , Zhou Huanyang
Published: November 2023

In recent years, excessive lateral deformation of subway shield tunnels has been observed due to adjacent engineering activities. This study examines the monitoring of excessive lateral deformation of the shield tunnel and the special steel plate reinforcement process to enhance the safety and stability of the operating subway tunnel structure. It uses a three-dimensional refined finite-element model of the shield tunnel for parametric structural loading simulation analysis to propose a structural deformation limit value suitable for the subway shield tunnel. This study’s findings indicated the following: (1) as observed from the engineering examples, a tunnel with significant elliptical deformation increases the likelihood of cracking and other structural issues in the adjacent subway shield tunnel segment; (2) as observed from the post-reinforcement monitoring data, the steel plate reinforcement method effectively enhances the load-bearing stability of the damaged tunnel structure; (3) based on the finite-element simulation results and the comprehensive review of practical conditions, the standard warning value for lateral deformation, using ellipticity evaluation of the subway shield tunnel, is established at 20‰, with a control value of 25‰. The outcomes of this research offer valuable insights into the operation, maintenance, and health monitoring of subway shield tunnels.
Flow-Induced Vibration of Cantilever Type Elastic Material in Straight Tricylinder
Authors: Guo Jiaqi , Liu Yi
Published: November 2023

The hydrodynamic performance and wake evaluation results of a cantilever flexible cylindrical triangular array at Re = 9000 and with L/D spacing ratios ranging from 3 to 7 are presented in this paper. The improved delayed separation eddy current simulation (IDDES) SST k-ω turbulence model and tetrahedral mesh are employed to solve the three-dimensional instantaneous flow field. The objective is to find the L/D ratio that the upstream cylinder has the most pronounced effect on the downstream cylinders, to quantify whether a flexible upstream cylinder is more favorable than the rigid upstream cylinder, and to know the flexible cylinder wake distribution. The findings indicate that, at Re = 9000, when the spacing ratio is 3~7 and the spacing ratio L/D is 6, the amplitude of the downstream cylinder is most affected by the wake of the upstream cylinder; the amplitude of downstream cylinders of the rigid upstream cylinder exerted a 1% or 2% greater effect than the flexible cylinder, with vortices predominantly concentrated in the middle and upper parts of the flexible cylinder rather than at its top.
Energy Efficiency in Historic Museums: The Interplay between Thermal Rehabilitation, Climate Control Strategies and Regional Climates
Authors: Silva Hugo Entradas , Henriques Fernando M. A.
Published: November 2023

Museums housed in historical buildings combine the intrinsic value of the collections with the historical and architectural values of the building itself. Although usually made with thick elements with high thermal inertia, very effective in damping and delaying the heat flow, these buildings are usually characterized by elements with low thermal resistance, poor-quality windows and low area/volume ratio in the noblest buildings, which renders them ineffective at maintaining a stable indoor climate adequate for conservation, comfort and energy efficiency issues. In this paper, a simulation study was carried out to analyze the impact of the building location (weather), thermal envelope and climate control strategies by analyzing a generic room of the National Museum of Ancient Art of Lisbon. A simulation study was carried out for 15 European cities to verify the impossibility of standardizing the rehabilitation solutions in cultural heritage since energy needs depend on the location. It was concluded that the focus on climate control strategies has great potential for energy reduction and that in temperate climates of southern Europe, the improvement of thermal transmittance has a reduced effect on the building’s response.
Toeplitz Operators on Fock Space over Cn with Invariant Symbols under the Action of the Unit Circle
Authors: González-Flores Carlos , Dupont-García Luis Alfredo , López-Martínez Raquiel Rufino , Hérnandez-Zamora Francisco Gabriel
Published: November 2023

The first goal of this paper is to find a representation of the Fock space on Cn in terms of the weighted Bergman spaces of the projective spaces CPn−1; i.e., every function in the Fock space can be written as a direct sum of elements in weighted Bergman space on CPn−1. Also, we study the C* algebras generated by Toeplitz operators where the symbols are taken from the following two families of functions: Firstly, the symbols depend on the moment map associated with the unit circle, and secondly, the symbols are invariant under the same action. Moreover, we analyze the commutative relations between these algebras, and we apply these results to find new commutative Banach algebras generated by Toeplitz operators on Fock space of Cn.
Optimal Inequalities on (α,β)-Type Almost Contact Manifold with the Schouten–Van Kampen Connection
Authors: Siddiqi Mohd Danish , Hakami Ali H.
Published: November 2023

In the current research, we develop optimal inequalities for submanifolds in trans-Sasakian manifolds or (α,β)-type almost contact manifolds endowed with the Schouten–Van Kampen connection (SVK-connection), including generalized normalized δ-Casorati Curvatures (δ-CC). We also discuss submanifolds on which the equality situations occur. Lastly, we provided an example derived from this research.
Quantifying Neutrosophic Research: A Bibliometric Study
Authors: Delcea Camelia , Domenteanu Adrian , Ioanăș Corina , Vargas Vanesa Mădălina , Ciucu-Durnoi Alexandra Nicoleta
Published: November 2023

In recent years, neutrosophic theory has garnered increasing attention within scholarly circles due to its applicability in various domains. Within these domains, the field of decision-making has derived significant advantages from the progressions in neutrosophic theory. Notably, neutrosophic theory has made substantial contributions by advancing and offering a range of aggregation operators and information measures specifically designed for enhancing decision-making processes. In this context, this study aims to conduct a comprehensive bibliometric analysis of the current research landscape in the field of neutrosophic theory, with a specific focus on understanding its applications and development trends. Our analysis reveals that the scientific literature addresses neutrosophic theory in a diverse range of applications. This examination encompasses a scrutiny of key contributors, affiliated academic institutions, influential publications, and noteworthy journals within the neutrosophic domain. To achieve this, we have curated a dataset comprising scholarly papers retrieved from Clarivate Analytics’ Web of Science Core Collection database, employing keywords closely aligned with neutrosophic theory and its applications, spanning a specified timeframe starting from the year in which the first paper on neutrosophic theory was published, namely, from 2005 until 2022. Our findings underscore sustained and robust scholarly interest in neutrosophic theory, characterized by a considerable high annual growth rate of 43.74% during the specified period. Additionally, our investigation delves into the identification and analysis of pivotal keywords and emerging trends, shedding light on prominent research trajectories within this domain. Furthermore, we elucidate collaborative networks among authors, their academic affiliations, and the global distribution across diverse countries and territories, providing valuable insights into the worldwide proliferation of neutrosophic research and applications. Employing n-gram analysis techniques across titles, keywords, abstracts, and keyword-plus fields unveils a multitude of applications where neutrosophic theory plays a central role. The analysis culminates in a review of globally cited documents and a comprehensive discussion highlighting the significance of neutrosophic theory in contemporary research and problem-solving contexts.
Mechanisms of Fibroblast Growth Factor 21 Adsorption on Macroion Layers: Molecular Dynamics Modeling and Kinetic Measurements
Authors: Wasilewska Monika , Dąbkowska Maria , Pomorska Agata , Batys Piotr , Kowalski Bogusław , Michna Aneta , Adamczyk Zbigniew
Published: November 2023

Molecular dynamic modeling and various experimental techniques, including multi-angle dynamic light scattering (MADLS), streaming potential, optical waveguide light spectroscopy (OWLS), quartz crystal microbalance with dissipation (QCM), and atomic force microscopy (AFM), were applied to determine the basic physicochemical parameters of fibroblast growth factor 21 in electrolyte solutions. The protein size and shape, cross-section area, dependence of the nominal charge on pH, and isoelectric point of 5.3 were acquired. These data enabled the interpretation of the adsorption kinetics of FGF 21 on bare and macrocation-covered silica investigated by OWLS and QCM. It was confirmed that the protein molecules irreversibly adsorbed on the latter substrate, forming layers with controlled coverage up to 0.8 mg m−2, while their adsorption on bare silica was much smaller. The viability of two cell lines, CHO-K1 and L-929, on both bare and macrocation/FGF 21-covered substrates was also determined. It is postulated that the acquired results can serve as useful reference systems for designing complexes that can extend the half-life of FGF 21 in its active state.
Navigating the Complexities of Traumatic Encephalopathy Syndrome (TES): Current State and Future Challenges
Authors: Fesharaki-Zadeh Arman
Published: November 2023

Chronic traumatic encephalopathy (CTE) is a unique neurodegenerative disease that is associated with repetitive head impacts (RHI) in both civilian and military settings. In 2014, the research criteria for the clinical manifestation of CTE, traumatic encephalopathy syndrome (TES), were proposed to improve the clinical identification and understanding of the complex neuropathological phenomena underlying CTE. This review provides a comprehensive overview of the current understanding of the neuropathological and clinical features of CTE, proposed biomarkers of traumatic brain injury (TBI) in both research and clinical settings, and a range of treatments based on previous preclinical and clinical research studies. Due to the heterogeneity of TBI, there is no universally agreed-upon serum, CSF, or neuroimaging marker for its diagnosis. However, as our understanding of this complex disease continues to evolve, it is likely that there will be more robust, early diagnostic methods and effective clinical treatments. This is especially important given the increasing evidence of a correlation between TBI and neurodegenerative conditions, such as Alzheimer’s disease and CTE. As public awareness of these conditions grows, it is imperative to prioritize both basic and clinical research, as well as the implementation of necessary safe and preventative measures.
Intermuscular Coherence during Quiet Standing in Sub-Acute Patients after Stroke: An Exploratory Study
Authors: Yamanaka Eiji , Goto Ryosuke , Kawakami Michiyuki , Tateishi Takaki , Kondo Kunitsugu , Nojima Ippei
Published: November 2023

Asymmetrically impaired standing control is a prevalent disability among stroke patients; however, most of the neuromuscular characteristics are unclear. Therefore, the main purpose of this study was to investigate between-limb differences in intermuscular coherence during quiet standing. Consequently, 15 patients who had sub-acute stroke performed a quiet standing task without assistive devices, and electromyography was measured on the bilateral tibialis anterior (TA), soleus (SL), and medial gastrocnemius (MG). The intermuscular coherence of the unilateral synergistic (SL–MG) pair and unilateral antagonist (TA–SL and TA–MG) pairs in the delta (0–5 Hz) and beta (15–35 Hz) bands were calculated and compared between the paretic and non-paretic limbs. The unilateral synergistic SL–MG coherence in the beta band was significantly greater in the non-paretic limb than in the paretic limb (p = 0.017), while unilateral antagonist TA–MG coherence in the delta band was significantly greater in the paretic limb than in the non-paretic limb (p < 0.01). During quiet standing, stroke patients showed asymmetry in the cortical control of the plantar flexor muscles, and synchronous control between the antagonistic muscles was characteristic of the paretic limb. This study identified abnormal muscle activity patterns and asymmetrical cortical control underlying impaired standing balance in patients with sub-acute stroke using an intermuscular coherence analysis.
Exploring Factors Affecting Impostor Syndrome among Undergraduate Clinical Medical Students at Chiang Mai University, Thailand: A Cross-Sectional Study
Authors: Shinawatra Purichaya , Kasirawat Chayada , Khunanon Phichittra , Boonchan Sorrathorn , Sangla Siripit , Maneeton Benchalak , Maneeton Narong , Kawilapat Suttipong
Published: November 2023

Impostor syndrome is a psychological condition that inhibits individuals’ ability to recognize their achievements such that they fear being exposed as forgers. It is common in medical students, particularly in the early stages of clerkship training while transitioning from preclinical to clinical training. This cross-sectional study assessed the prevalence and associated factors of the imposter phenomenon among medical clinical students using the Clance Impostor Phenomenon Scale (CIPS), focusing on sociodemographic characteristics, mental health status, and occurrence of the impostor phenomenon. Out of 228 undergraduate clinical-year medical students, 108 (47.4%) reported experiencing the impostor phenomenon. The results from the multivariable analysis showed that high levels of stress (adjusted odds ratio = 2.315; 95% confidence interval = 1.105–4.853), anxiety (6.462; 1.374–30.392), and depression (4.219; 1.448–12.290) were significantly associated with an increased risk of experiencing the impostor phenomenon. We found no difference between participants in the early or later years of clerkship training. The study highlights the prevalence of impostor syndrome among medical students and its link to mental health issues. Addressing this issue through education, mentorship, systemic problem solving, normalizing failure, and monitoring and treating mental health issues could help students reach and realize their full educational and professional potential.
Motivations for Social Withdrawal, Mental Health, and Well-Being in Emerging Adulthood: A Person-Oriented Approach
Authors: Sette Stefania , Pecora Giulia , Laghi Fiorenzo , Coplan Robert J.
Published: November 2023

Emerging adults seek solitude because of different underlying motivational and emotional processes. The current short-term longitudinal study aimed to: (1) identify subgroups of socially withdrawn emerging adults characterized by different motivations for solitude (shyness, unsociability, social avoidance) and affect (positive, negative); and (2) compare these subgroups in terms of indices of internalizing difficulties and life-satisfaction. Participants were N = 348 university students (Mage = 21.85 years, SD = 3.84) from Italy, who completed online questionnaires at two-time points separated by three months. Results from a latent profile analysis (LPA) suggested three distinct subgroups characterized by different social withdrawal motivations (i.e., shy, unsociable, and socially avoidant), as well as a non-withdrawn subgroup (characterized by low social withdrawal motivations, low negative affect, and high positive affect). Among the results, the socially avoidant subgroup reported the highest levels of social anxiety, whereas the avoidant and shy subgroups reported the highest loneliness and lowest life satisfaction. The unsociable subgroup appeared to be the most well-adjusted subgroup of socially withdrawn emerging adults and reported similar levels of life satisfaction as the non-withdrawn subgroup. Our findings confirmed the heterogeneity of emerging adults’ experiences of solitude, with different motivations for social withdrawal appearing to confer a differential risk for maladjustment.
Looking for the Key to Winning: Psychophysiological Predicting Factors in Healthy University Students
Authors: Costa Raquel , Abad-Tortosa Diana , Alacreu-Crespo Adrian , Saiz-Clar Elena , Salvador Alicia , Serrano Miguel Ángel
Published: November 2023

Performance in competitive situations has been linked to various psychobiological factors such as personality traits (e.g., competitiveness), situational appraisal (e.g., motivation), and cardiovascular response (e.g., heart rate). However, it remains unclear whether these factors can predict competitive success. This paper aims to assess, through discriminant analysis, the predictive capacity of these psychobiological variables regarding the likelihood of winning, ultimately delineating a psychophysiological profile associated with success. Across three distinct studies, a total of 154 participants (66 men) engaged in a face-to-face laboratory competition. Prior to the competition, assessments of competitiveness traits, anxiety, self-efficacy, and motivation were conducted, and heart rate reactivity during the competition was measured. These variables collectively formed the basis for constructing the predictive model. The results of the initial study demonstrated that our model accurately classified 68.8% of the cases. Specifically, high levels of competitiveness, self-efficacy, motivation, and heart rate reactivity, coupled with low anxiety, were predictive of winning. These findings were subsequently replicated in two independent validation samples involving both men and women (studies 2 and 3), thereby reinforcing the robustness of the earlier results. In conclusion, our findings suggest that the psychological state preceding competition, along with cardiovascular reactivity, may serve as predictors for the probability of winning.
Key Economic Drivers Enabling Municipal Renewable Energy Communities’ Benefits in the Italian Context
Authors: Ruggieri Gianluca , Gambassi Rebecca , Zangheri Paolo , Caldera Matteo , Verde Stefano F.
Published: November 2023

Community energy is a buzzword that has historically included various type of experiences. In 2018, the Renewable Energy Directive (RED II) legally defined renewable energy communities (RECs). Based on the first pilot projects and on the Italian legal framework, a possible REC configuration of municipal initiative with a high replicability potential is one in which a photovoltaic system is installed in educational buildings and shares energy with neighbouring residential consumers. This analysis presents an economical evaluation of different possible scenarios depending on variables such as solar radiation, system capacity, fraction of self-consumption within the REC, installation costs and energy prices. All the scenarios identified and analysed show positive economic indexes, although the energy and economic results may significantly vary depending on the variables studied. In the analysed case studies, the Net Present Value (after 20 years) is between kEUR 51 and kEUR 478; the internal rate of return is between 9.5% and 88%; the payback time is between 13.6 years and 1.1 years. The results of this analysis are relevant as they allow us to better understand the critical factors that can enable REC in providing local economic and social benefits to have a real impact on energy poverty or on the provision of local social services.
Seismic Performance of a 1:4 Scale Two-Story Rammed Earth Model Reinforced with Steel Plates Tested on a Bi-Axial Shaking Table
Authors: Barrera Natalia , Ruiz Daniel M. , Reyes Juan C. , Alvarado Yezid A. , Carrasco-Beltrán Daniela
Published: November 2023

During the 16th and 17th centuries, Latin American cities adopted earthen construction techniques from European colonizers. As a result, rammed earth (RE) buildings now occupy an important place in Latin America’s cultural heritage. However, earthquakes around the world have shown that unreinforced earthen constructions are highly vulnerable. For several years, researchers in northern South America have been proposing a technique that consists of installing confining steel plates (or wooden elements) on both sides of the RE walls to form a grid. This system has shown excellent performance in controlling seismic damage and increasing strength and ductility capacity. Although researchers have tested full-scale one- and two-story earthen walls under pseudo-static loading in the laboratory, and one- and two-story earthen walls at 1:1 and 1:2 scales on uniaxial and biaxial shaking tables, the behavior of a complete reinforced module (one- or two-story) on a shaking table has never been assessed. The present study presents the results of shaking table tests performed on two-story RE modules at 1:4 scale. The experimental data indicate that the retrofit system with confining steel plates was effective in reducing the seismic damage of earthen constructions. In addition, the comparison of the results of the 1:4 scale tests with the 1:2 and 1:1 scale tests previously conducted by the researchers shows that the acceleration levels of the equivalent prototypes are in the same order of magnitude for the three scales.
Quantification of the Culture Stability of Stem Cell Fractions from Oral-Derived, Human Mesenchymal Stem Cell Preparations: A Significant Step toward the Clinical Translation of Cell Therapies
Authors: Chopra Hitesh , Cao Chen , Sommer Celia , Dahlkemper Alex , Sugai James , Sherley James L. , Kaigler Darnell
Published: November 2023

A continuing limitation and major challenge in the development and utilization of predictable stem cell therapies (SCTs) is the determination of the optimal dosages of stem cells. Herein, we report the quantification of stem cell fractions (SCF) of human mesenchymal stem cell (MSC) preparations derived from oral tissues. A novel computational methodology, kinetic stem cell (KSC) counting, was used to quantify the SCF and specific cell culture kinetics of stem cells in oral alveolar bone-derived MSC (aBMSCs) from eight patients. These analyses established, for the first time, that the SCF within these heterogeneous, mixed-cell populations differs significantly among donors, ranging from 7% to 77% (ANOVA p < 0.0001). Both the initial SCF of aBMSC preparations and changes in the level of the SCF with serial culture over time showed a high degree of inter-donor variation. Hence, it was revealed that the stability of the SCF of human aBMSC preparations during serial cell culture shows inter-donor variation, with some patient preparations exhibiting sufficient stability to support the long-term net expansion of stem cells. These findings provide important insights for the clinical-scale expansion and biomanufacturing of MSCs, which can facilitate establishing more effective and predictable outcomes in clinical trials and treatments employing SCT.
WAVE2 Regulates Actin-Dependent Processes Induced by the B Cell Antigen Receptor and Integrins
Authors: Bedi Abhishek , Choi Kate , Keane Connor , Bolger-Munro Madison , Ambrose Ashley R. , Gold Michael R.
Published: November 2023

B cell antigen receptor (BCR) signaling induces actin cytoskeleton remodeling by stimulating actin severing, actin polymerization, and the nucleation of branched actin networks via the Arp2/3 complex. This enables B cells to spread on antigen-bearing surfaces in order to increase antigen encounters and to form an immune synapse (IS) when interacting with antigen-presenting cells (APCs). Although the WASp, N-WASp, and WAVE nucleation-promoting factors activate the Arp2/3 complex, the role of WAVE2 in B cells has not been directly assessed. We now show that both WAVE2 and the Arp2/3 complex localize to the peripheral ring of branched F-actin when B cells spread on immobilized anti-Ig antibodies. The siRNA-mediated depletion of WAVE2 reduced and delayed B cell spreading on immobilized anti-Ig, and this was associated with a thinner peripheral F-actin ring and reduced actin retrograde flow compared to control cells. Depleting WAVE2 also impaired integrin-mediated B cell spreading on fibronectin and the LFA-1-induced formation of actomyosin arcs. Actin retrograde flow amplifies BCR signaling at the IS, and we found that depleting WAVE2 reduced microcluster-based BCR signaling and signal amplification at the IS, as well as B cell activation in response to antigen-bearing cells. Hence, WAVE2 contributes to multiple actin-dependent processes in B lymphocytes.
NLRP3-Induced NETosis: A Potential Therapeutic Target for Ischemic Thrombotic Diseases?
Authors: Kumar Rahul , Patil Gokul , Dayal Sanjana
Published: November 2023

Ischemic thrombotic disease, characterized by the formation of obstructive blood clots within arteries or veins, is a condition associated with life-threatening events, such as stroke, myocardial infarction, deep vein thrombosis, and pulmonary embolism. The conventional therapeutic strategy relies on treatments with anticoagulants that unfortunately pose an inherent risk of bleeding complications. These anticoagulants primarily target clotting factors, often overlooking upstream events, including the release of neutrophil extracellular traps (NETs). Neutrophils are integral components of the innate immune system, traditionally known for their role in combating pathogens through NET formation. Emerging evidence has now revealed that NETs contribute to a prothrombotic milieu by promoting platelet activation, increasing thrombin generation, and providing a scaffold for clot formation. Additionally, NET components enhance clot stability and resistance to fibrinolysis. Clinical and preclinical studies have underscored the mechanistic involvement of NETs in the pathogenesis of thrombotic complications, since the clots obtained from patients and experimental models consistently exhibit the presence of NETs. Given these insights, the inhibition of NETs or NET formation is emerging as a promising therapeutic approach for ischemic thrombotic diseases. Recent investigations also implicate a role for the nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome as a mediator of NETosis and thrombosis, suggesting that NLRP3 inhibition may also hold potential for mitigating thrombotic events. Therefore, future preclinical and clinical studies aimed at identifying and validating NLRP3 inhibition as a novel therapeutic intervention for thrombotic disorders are imperative.
The Role of Extracellular Vesicles in the Pathogenesis and Treatment of Rheumatoid Arthritis and Osteoarthritis
Authors: Bakinowska Estera , Kiełbowski Kajetan , Pawlik Andrzej
Published: November 2023

Cells can communicate with each other through extracellular vesicles (EVs), which are membrane-bound structures that transport proteins, lipids and nucleic acids. These structures have been found to mediate cellular differentiation and proliferation apoptosis, as well as inflammatory responses and senescence, among others. The cargo of these vesicles may include immunomodulatory molecules, which can then contribute to the pathogenesis of various diseases. By contrast, EVs secreted by mesenchymal stem cells (MSCs) have shown important immunosuppressive and regenerative properties. Moreover, EVs can be modified and used as drug carriers to precisely deliver therapeutic agents. In this review, we aim to summarize the current evidence on the roles of EVs in the progression and treatment of rheumatoid arthritis (RA) and osteoarthritis (OA), which are important and prevalent joint diseases with a significant global burden.
Induced Codeposition of Tungsten with Zinc from Aqueous Citrate Electrolytes
Authors: Kazimierczak Honorata , Eliaz Noam
Published: November 2023

Zinc–tungsten coatings have been considered as environmentally friendly, and corrosion- and wear-resistant coatings. Here, Zn–W coatings were successfully electrodeposited from an aqueous solution. Citrate-based electrolytes with pH in the range of 3.0 to 5.7 were used as plating baths. The kinetics of co-reduction in the Zn(II)–W(VI)–Cit system was studied on the basis of partial polarization curves. The effects of applied potential, electrolyte composition, pH, hydrodynamic conditions and passed charge on the electrodeposition of Zn–W layers were determined. X-ray photoelectron spectroscopy confirmed the presence of metallic tungsten co-deposited with zinc. X-ray diffraction analysis revealed the formation of hexagonal Zn–W phase resulting from a substitution of Zn atoms by W atoms in the Zn crystal lattice. The formation of the proper stable and electroactive W(VI) and Zn(II) complexes is the first crucial factor enabling the induced codeposition of Zn–W alloys. The tungsten content in the Zn–W deposit is closely related to the concentration of electroactive tungstate–citrate species and its ratio relative to the zinc–citrate electroactive species in the electrolytic bath. The oxidation state of tungsten in the electrodeposited Zn–W layers can be controlled mainly by the applied deposition potential and by the bath pH, which determines the type of W(VI)–Cit species that can be reduced.
Automatic Identification Method of Defects in Concrete Structures Strengthened with Composite Materials Based on a Multi-Scale Model
Authors: Lu Xiaoming , Lin Xinyan
Published: November 2023

Due to the inconsistent geometric characteristics of reinforced concrete structures with composite materials, some echo signals have a lower degree of clarity, resulting in problems such as long time, small range, and low accuracy in identifying structural defects. Therefore, in order to improve the accuracy and efficiency of defect identification in composite material reinforced concrete structures, a multi-scale model based on the automatic defect identification method for composite material reinforced concrete structures is proposed. Using the interface connection method, based on continuous distribution coupling and the uniform weighting coefficient calculation method to weigh the interface nodes, we determined the interface connection mode and analyzed the stress–strain relationship. The impact echo method was used to analyze the degree of high-frequency stress wave scattering caused by internal non-uniformity in composite reinforced concrete, and the fast Fourier transform conversion algorithm was used to generate amplitude–frequency curves and resolved thickness or defect depth. The experimental results show that the multi-scale finite element simulation structure of this method is clear and accurate, and although there are errors, they do not affect the simulation results of the structure. The impact echo detection effect is obvious; it can automatically identify defects in composite reinforced concrete structures and quickly and accurately identify defects in different states and positions of composite reinforced concrete, with a recognition accuracy of 98%.
The Effect of TIG Welding Heat Input on the Deformation of a Thin Bending Plate and Its Weld Zone
Authors: Guo Nan , Hu Hao , Tang Xiaojie , Ma Xiqiang , Wang Xiao
Published: November 2023

Heat input is a crucial parameter in the process of welding thin plates. It has a direct impact on the quality of the weld and the degree of deformation caused during welding. This study investigates the impact of heat input on the deformation of a thin bending plate and its weld zone using the thermoelastic–plastic finite element method. The accuracy of the model is ascertained using the non-contact inspection method utilizing digital image correlation technology. The welding deformation patterns of thin bending plates with a radius of 500 mm were analyzed at various welding heat inputs ranging from 173 J/mm to 435 J/mm. The results indicate that the finite element prediction model proposed in this paper is highly accurate. It has been observed that, under this range of thermal input, the thin bent plates undergo saddle deformation. By examining the correlation between heat input and the maximum deformation outside of the plane, it has been determined that a heat input of at least 50 J/mm is required for the thin bending plate to experience out-of-plane deformation. Additionally, as the level of heat input increases, so too does the out-of-plane deformation of the thin bending plate. After the completion of the welding cooling process, the transverse shrinkage at the weld seam of the thin bend plate is twice that of the longitudinal shrinkage. However, the transverse deformation of the bend plate is not significantly different from the longitudinal deformation.
Building Manganese Halide Hybrid Materials with 0D, 1D, and 2D Dimensionalities
Authors: Peoble Anna , Gallegos Kandee , Ozide Michael O. , Castañeda Raúl
Published: November 2023

In recent years, metal-halide hybrid materials have attracted considerable attention because materials, such as lead-iodide perovskites, can have excellent properties as photovoltaics, light-emitting devices, and photodetectors. These materials can be obtained in different dimensionalities (1D, 2D, and 3D), which directly affects their properties. In this article, we built 0D, 1D, and 2D manganese halide materials with 3-aminopyridine (3AP) or 4-ethylpyridine (4EtP). Two isomorphic complexes with 3AP and manganese chloride ([MnCl2(3AP)4]) or manganese bromide ([MnBr2(3AP)4]) were obtained with the amino group in 3AP assisting in the formation of 0D structures via hydrogen bonding. By modifying the reaction conditions, 3AP can also be used to build a 2D coordination polymer with manganese chloride ([MnCl33AP]− [3APH]+). Unlike 3AP, 4EtP does not provide the opportunity for hydrogen bonding, leading to the formation of two additional isomorphic compounds built of individual 1D chains with manganese chloride ({MnCl3(4EtP)2}n) and manganese bromide ({MnBr2(4EtP)2}n). In the visible region, the 0D and 1D manganese halide compounds have similar photoluminescence properties; however, 0D and 1D have different near-IR emissions. In conclusion, hydrogen-bonding groups can play a role in the formation of discrete manganese-halide units, 1D halide chains, or 2D polymeric sheets.
Polyaniline–Titanium Dioxide Heterostructures as Efficient Photocatalysts: A Review
Authors: Fu Yongqiang , Janczarek Marcin
Published: November 2023

This review paper focuses on present issues concerning the use of polyaniline–TiO2 heterostructures as potentially efficient photocatalysts. Conducting polymers such as polyaniline (PANI) are used in the preparation of heterojunction systems with metal oxides like titania to overcome their inherent limitations, e.g., their sole absorption of UV light and overly fast recombination of charge carriers. This review discusses preparation methods, the properties of resultant products and mechanistic aspects. An important part of this paper is its presentation of the major challenges and future perspectives of such photocatalytic materials.
Construction of Oxygen Vacancies of Zr-Doped CeO2 with Enhanced Dye Adsorption Performance
Authors: Luo NingTao , Fan Lei , Chen YunQiang , Lan WeiGuang
Published: November 2023

Congo red (CR), a highly pigmented anionic dye, is highly toxic and resistant to degradation. The discharge of CR wastewater into the natural environment can lead to ecological destruction and harm to human health. CeO2 as an adsorbent possesses the advantages of excellent acid and alkali resistance, biocompatibility, stable physical and chemical properties, and nontoxic by-products. The impact of Zr doping on the adsorption performance of nano-CeO2 was investigated. XPS and Raman characterisation revealed that Zr doping effectively enhanced the oxygen vacancy ratio at the active sites for CR adsorption on the surface of nano-CeO2. When the doping amount of Zr was 3%, the nanoparticles with the best adsorption properties were obtained, and the adsorption amount of CR at room temperature was as high as 3642.05 mg/g, which was approximately three times the adsorption amount of undoped CeO2. This excellent adsorption property shows good prospects for the removal of anionic dyes from wastewater.
Diagnostic Challenges in ABCA4-Associated Retinal Degeneration: One Gene, Many Phenotypes
Authors: Tan Tien-En , Tang Rachael Wei Chao , Chan Choi Mun , Mathur Ranjana S. , Fenner Beau J.
Published: November 2023

(1) Purpose: ABCA4-associated retinal degeneration (ABCA4-RD) is a phenotypically diverse disease that often evades diagnosis, even by experienced retinal specialists. This may lead to inappropriate management, delayed genetic testing, or inaccurate interpretation of genetic testing results. Here, we illustrate the phenotypic diversity of ABCA4-RD using a series of representative cases and compare these to other conditions that closely mimic ABCA4-RD. (2) Methods: Genetically confirmed ABCA4-RD cases with representative phenotypes were selected from an inherited retinal disease cohort in Singapore and compared to phenocopies involving other retinal diseases. (3) Results: ABCA4-RD phenotypes in this series included typical adolescent-onset Stargardt disease with flecks, bull’s eye maculopathy without flecks, fundus flavimaculatus, late-onset Stargardt disease, and severe early-onset Stargardt disease. Phenocopies of ABCA4-RD in this series included macular dystrophy, pattern dystrophy, cone dystrophy, advanced retinitis pigmentosa, Leber congenital amaurosis, drug toxicity, and age-related macular degeneration. Key distinguishing features that often suggested a diagnosis of ABCA4-RD were the presence of peripapillary sparing, macular involvement and centrifugal distribution, and a recessive pedigree. (4) Conclusions: ABCA4-RD demonstrates a remarkable phenotypic spectrum that makes diagnosis challenging. Awareness of the clinical spectrum of disease can facilitate prompt recognition and accurate diagnostic testing.
Controversies Regarding Mesh Utilisation and the Attitude towards the Appendix in Amyand’s Hernia—A Systematic Review
Authors: Bratu Dan , Mihetiu Alin , Sandu Alexandra , Boicean Adrian , Roman Mihai , Ichim Cristian , Dura Horatiu , Hasegan Adrian
Published: November 2023

Inguinal hernia containing the vermiform appendix is a rare entity. It is more common in children than in adults. It can be discovered incidentally during the surgical intervention performed for the cure of the inguinal hernia or when the appendix shows inflammatory changes, a situation that can lead to diagnostic confusion with a number of other diseases. Imaging can guide the diagnosis, which often comes as an intraoperative surprise. The therapeutic approach is controversial both in terms of whether or not to perform an appendectomy in the case of an appendix without inflammatory changes and especially in terms of using a mesh during the hernia repair process. Since the pathology is not very frequent, there are no standardized stages in terms of surgical ethics that can guarantee good surgical practice. The study aimed to carry out a review of the specialized literature to obtain some conclusions or trends regarding the management of this pathology. The low frequency of this type of hernia did not allow the consultation of large-scale studies or extensive reviews focusing on case reports or case series communications. The obtained results were statistically analyzed and integrated in relation to the surgical attitude depending on the particularities of the condition.
Computational Intelligence-Based Stuttering Detection: A Systematic Review
Authors: Alnashwan Raghad , Alhakbani Noura , Al-Nafjan Abeer , Almudhi Abdulaziz , Al-Nuwaiser Waleed
Published: November 2023

Stuttering is a widespread speech disorder affecting people globally, and it impacts effective communication and quality of life. Recent advancements in artificial intelligence (AI) and computational intelligence have introduced new possibilities for augmenting stuttering detection and treatment procedures. In this systematic review, the latest AI advancements and computational intelligence techniques in the context of stuttering are explored. By examining the existing literature, we investigated the application of AI in accurately determining and classifying stuttering manifestations. Furthermore, we explored how computational intelligence can contribute to developing innovative assessment tools and intervention strategies for persons who stutter (PWS). We reviewed and analyzed 14 refereed journal articles that were indexed on the Web of Science from 2019 onward. The potential of AI and computational intelligence in revolutionizing stuttering assessment and treatment, which can enable personalized and effective approaches, is also highlighted in this review. By elucidating these advancements, we aim to encourage further research and development in this crucial area, enhancing in due course the lives of PWS.
Auditory Brainstem Response Data Preprocessing Method for the Automatic Classification of Hearing Loss Patients
Authors: Ma Jun , Seo Jae-Hyun , Moon Il Joon , Park Moo Kyun , Lee Jong Bin , Kim Hantai , Ahn Joong Ho , Jang Jeong Hun , Lee Jong Dae , Choi Seong Jun , Hong Min
Published: November 2023

Auditory brainstem response (ABR) is the response of the brain stem through the auditory nerve. The ABR test is a method of testing for loss of hearing through electrical signals. Basically, the test is conducted on patients such as the elderly, the disabled, and infants who have difficulty in communication. This test has the advantage of being able to determine the presence or absence of objective hearing loss by brain stem reactions only, without any communication. This paper proposes the image preprocessing process required to construct an efficient graph image data set for deep learning models using auditory brainstem response data. To improve the performance of the deep learning model, we standardized the ABR image data measured on various devices with different forms. In addition, we applied the VGG16 model, a CNN-based deep learning network model developed by a research team at the University of Oxford, using preprocessed ABR data to classify the presence or absence of hearing loss and analyzed the accuracy of the proposed method. This experimental test was performed using 10,000 preprocessed data, and the model was tested with various weights to verify classification learning. Based on the learning results, we believe it is possible to help set the criteria for preprocessing and the learning process in medical graph data, including ABR graph data.