bluuebunny/crossref_metadata_2025 huggingface dataset:
The Optimization of Hybrid Power Systems with Renewable Energy and Hydrogen Generation
Authors: Wang Fu-Cheng , Hsiao Yi-Shao , Yang Yi-Zhe
Published: July 2018

This paper discusses the optimization of hybrid power systems, which consist of solar cells, wind turbines, fuel cells, hydrogen electrolysis, chemical hydrogen generation, and batteries. Because hybrid power systems have multiple energy sources and utilize different types of storage, we first developed a general hybrid power model using the Matlab/SimPowerSystemTM, and then tuned model parameters based on the experimental results. This model was subsequently applied to predict the responses of four different hybrid power systems for three typical loads, without conducting individual experiments. Furthermore, cost and reliability indexes were defined to evaluate system performance and to derive optimal system layouts. Finally, the impacts of hydrogen costs on system optimization was discussed. In the future, the developed method could be applied to design customized hybrid power systems.
Quality and Safety of Meat Products
Authors: Panea Begoña , Ripoll Guillermo
Published: July 2018

n/a
See, Feel, Taste: The Influence of Receptacle Colour and Weight on the Evaluation of Flavoured Carbonated Beverages
Authors: Mielby Line Ahm , Wang Qian Janice , Jensen Sidsel , Bertelsen Anne Sjoerup , Kidmose Ulla , Spence Charles , Byrne Derek Victor
Published: July 2018

A study was designed to assess whether the individual and combined effects of product-intrinsic and product-extrinsic factors influence the perception of, and liking for, carbonated beverages. Four hundred and one participants tasted samples of one of three flavours (grapefruit, lemon, or raspberry) of carbonated aromatised non-alcoholic beer. The beverages were served in receptacles that differed in terms of their colour (red or black) and weight (lighter—no added weight, or heavier—20 g weight added). Each participant received the same beverage in each of the four different receptacles, and rated how much they liked the drink. They also evaluated the intensity of each beverage’s sweetness, bitterness, sourness, and carbonation. The results revealed a significant influence of the colour of the receptacle on perceived carbonation, with the beverages tasted from the red receptacles being rated as tasting more carbonated than when served in black receptacles. In terms of flavour, the participants liked the raspberry beverage significantly more than the others, while also rating it as tasting sweeter and less bitter than either of the other flavours. Furthermore, there was a more complex interaction effect involving the weight of the receptacle: Specifically, the perceived bitterness of the beverage moderated the relationship between the receptacle weight and the perceived carbonation. At high levels of bitterness, the drinks were perceived to be more carbonated when served from the heavier receptacle as compared to the lighter one. These findings highlight the complex interplay of product extrinsic and intrinsic factors on the flavour/mouthfeel perception and preference for beverages, and stress the importance of taking both internal product development and external packaging into account in the design of health-oriented beverages.
Insights into Avian Incomplete Dosage Compensation: Sex-Biased Gene Expression Coevolves with Sex Chromosome Degeneration in the Common Whitethroat
Authors: Sigeman Hanna , Ponnikas Suvi , Videvall Elin , Zhang Hongkai , Chauhan Pallavi , Naurin Sara , Hansson Bengt
Published: July 2018

Non-recombining sex chromosomes (Y and W) accumulate deleterious mutations and degenerate. This poses a problem for the heterogametic sex (XY males; ZW females) because a single functional gene copy often implies less gene expression and a potential imbalance of crucial expression networks. Mammals counteract this by dosage compensation, resulting in equal sex chromosome expression in males and females, whereas birds show incomplete dosage compensation with significantly lower expression in females (ZW). Here, we study the evolution of Z and W sequence divergence and sex-specific gene expression in the common whitethroat (Sylvia communis), a species within the Sylvioidea clade where a neo-sex chromosome has been formed by a fusion between an autosome and the ancestral sex chromosome. In line with data from other birds, females had lower expression than males at the majority of sex-linked genes. Results from the neo-sex chromosome region showed that W gametologs have diverged functionally to a higher extent than their Z counterparts, and that the female-to-male expression ratio correlated negatively with the degree of functional divergence of these gametologs. We find it most likely that sex-linked genes are being suppressed in females as a response to W chromosome degradation, rather than that these genes experience relaxed selection, and thus diverge more, by having low female expression. Overall, our data of this unique avian neo-sex chromosome system suggest that incomplete dosage compensation evolves, at least partly, through gradual accumulation of deleterious mutations at the W chromosome and declining female gene expression.
Cryomorphological Topographies in the Study of Ice Caves
Authors: Gómez-Lende Manuel , Sánchez-Fernández Manuel
Published: July 2018

The current interest in ice caves requires that their varied manifestations be known as accurately as possible in view of their responses to a global change and also to their great potential as paleoenvironmental witnesses. This phenomenon has been known about for a long time but is still scarcely studied from the point of view of its cryological values and the evolution and distribution of many of their morphologies. For this, the development of cryomorphological topographies from traditional techniques to geodetic surveys with different tools, including terrestrial laser scanning, is one of the most current ways to characterize and quantify this type of cryospheric phenomena. It represents a new kind of periglacial cartography whose use is feasible in spite of the difficulties these environments present.
Mercury Contamination in Riverine Sediments and Fish Associated with Artisanal and Small-Scale Gold Mining in Madre de Dios, Peru
Authors: Martinez Gerardo , McCord Stephen A. , Driscoll Charles T. , Todorova Svetoslava , Wu Steven , Araújo Julio F. , Vega Claudia M. , Fernandez Luis E.
Published: July 2018

Artisanal and small-scale gold mining (ASGM) in Madre de Dios, Peru, continues to expand rapidly, raising concerns about increases in loading of mercury (Hg) to the environment. We measured physicochemical parameters in water and sampled and analyzed sediments and fish from multiple sites along one ASGM-impacted river and two unimpacted rivers in the region to examine whether Hg concentrations were elevated and possibly related to ASGM activity. We also analyzed the 308 fish samples, representing 36 species, for stable isotopes (δ15N and δ13C) to estimate their trophic position. Trophic position was positively correlated with the log-transformed Hg concentrations in fish among all sites. There was a lack of relationship between Hg concentrations in fish and either Hg concentrations in sediments or ASGM activity among sites, suggesting that fish Hg concentrations alone is not an ideal bioindicator of site-specific Hg contamination in the region. Fish Hg concentrations were not elevated in the ASGM-impacted river relative to the other two rivers; however, sediment Hg concentrations were highest in the ASGM-impacted river. Degraded habitat conditions and commensurate shifts in fish species and ecological processes may influence Hg bioaccumulation in the ASGM-impacted river. More research is needed on food web dynamics in the region to elucidate any effects caused by ASGM, especially through feeding relationships and food sources.
What Are the Net Benefits of Reducing the Ozone Standard to 65 ppb? An Alternative Analysis
Authors: Lange Sabine S. , Mulholland Sean E. , Honeycutt Michael E.
Published: July 2018

In October 2015, the United States Environmental Protection Agency (EPA) lowered the level of the ozone National Ambient Air Quality Standard (NAAQS) from 0.075 ppm to 0.070 ppm (annual 4th highest daily maximum 8-h concentration, averaged over three years). The EPA estimated a 2025 annual national non-California net benefit of $1.5 to $4.5 billion (2011$, 7% discount rate) for a 0.070 ppm standard, and a −$1.0 to $14 billion net benefit for an alternative 0.065 ppm standard. The purpose of this work is to present a combined toxicological and economic assessment of the EPA’s benefit-cost analysis of the 2015 ozone NAAQS. Assessing the quality of the epidemiology studies based on considerations of bias, confounding, chance, integration of evidence, and application of the studies for future population risk estimates, we derived several alternative benefits estimates. We also considered the strengths and weaknesses of the EPA’s cost estimates (e.g., marginal abatement costs), as well as estimates completed by other authors, and provided our own alternative cost estimate. Based on our alternative benefits and cost calculations, we estimated an alternative net benefit of between −$0.3 and $1.8 billion for a 0.070 ppm standard (2011 $, 7% discount rate) and between −$23 and −$17 billion for a 0.065 ppm standard. This work demonstrates that alternative reasonable assumptions can generate very difference cost and benefits estimates that may impact how policy makers view the outcomes of a major rule.
Genome-Wide Characterization and Analysis of Metallothionein Family Genes That Function in Metal Stress Tolerance in Brassica napus L.
Authors: Pan Yu , Zhu Meichen , Wang Shuxian , Ma Guoqiang , Huang Xiaohu , Qiao Cailin , Wang Rui , Xu Xinfu , Liang Ying , Lu Kun , Li Jiana , Qu Cunmin
Published: July 2018

Brassica plants exhibit both high biomass productivity and high rates of heavy metal absorption. Metallothionein (MT) proteins are low molecular weight, cysteine-rich, metal-binding proteins that play crucial roles in protecting plants from heavy metal toxicity. However, to date, MT proteins have not been systematically characterized in Brassica. In this study, we identified 60 MTs from Arabidopsis thaliana and five Brassica species. All the MT family genes from Brassica are closely related to Arabidopsis MTs, encoding putative proteins that share similar functions within the same clades. Genome mapping analysis revealed high levels of synteny throughout the genome due to whole genome duplication and segmental duplication events. We analyzed the expression levels of 16 Brassica napus MTs (BnaMTs) by RNA-sequencing and real-time RT-PCR (RT-qPCR) analysis in plants under As3+ stress. These genes exhibited different expression patterns in various tissues. Our results suggest that BnaMT3C plays a key role in the response to As3+ stress in B. napus. This study provides insight into the phylogeny, origin, and evolution of MT family members in Brassica, laying the foundation for further studies of the roles of MT proteins in these important crops.
β-Adrenoceptors Trigger Melatonin Synthesis in Phagocytes
Authors: Pires-Lapa Marco A. , Carvalho-Sousa Claudia E. , Cecon Erika , Fernandes Pedro A. , Markus Regina P.
Published: July 2018

Melatonin (5-methoxy-N-acetylserotonin), the pineal hormone, is also synthesized by immune-competent cells. The pineal hormone signals darkness, while melatonin synthesized on demand by activated macrophages at any hour of the day acts locally, favoring regulatory/tolerant phenotypes. Activation of β-adrenoceptors in pinealocytes is the main route for triggering melatonin synthesis. However, despite the well-known role of β-adrenoceptors in the resolution macrophage phenotype (M2), and the relevance of macrophage synthesized melatonin in facilitating phagocytic activity, there is no information regarding whether activation of β-adrenoceptors would induce melatonin synthesis by monocytes. Here we show that catecholamines stimulate melatonin synthesis in bone marrow-derived dendritic cells and RAW 264.7 macrophages. Activation of β-adrenoceptors promotes the synthesis of melatonin by stimulating cyclic AMP/protein kinase A (PKA) pathway and by activating the nuclear translocation of NF-κB. Considering the great number of macrophages around sympathetic nerve terminals, and the relevance of this system for maintaining macrophages in stages compatible to low-grade inflammation, our data open the possibility that extra-pineal melatonin acts as an autocrine/paracrine signal in macrophages under resolution or tolerant phenotypes.
Neutrosophic αψ-Homeomorphism in Neutrosophic Topological Spaces
Authors: Parimala Mani , Jeevitha Ranganathan , Jafari Saeid , Smarandache Florentin , Udhayakumar Ramalingam
Published: July 2018

In this article, the concept of neutrosophic homeomorphism and neutrosophic αψ homeomorphism in neutrosophic topological spaces is introduced. Further, the work is extended as neutrosophic αψ∗ homeomorphism, neutrosophic αψ open and closed mapping and neutrosophic Tαψ space in neutrosophic topological spaces and establishes some of their related attributes.
Ammonia vs. Lactic Acid in Predicting Positivity of Microbial Culture in Sepsis: The ALPS Pilot Study
Authors: Numan Yazan , Jawaid Yasir , Hirzallah Hisham , Kusmic Damir , Megri Mohammad , Aqtash Obadah , Amro Ahmed , Mezughi Haitem , Maher Emmon , Raru Yonas , Numan Jamil , Akpanudo Sutoidem , Khitan Zeid , Shweihat Yousef
Published: July 2018

Objective: The use of serum ammonia as a novel marker for sepsis compared to lactic acid levels in intensive care unit (ICU) patients. Design and Interventions: Single arm, prospective clinical trial to collect arterial blood samples from patients with sepsis. Serial ammonia and lactic acid levels were sent every six hours for a total of three days. Measurements and results: Compare mean levels of ammonia and lactic acid in terms of diagnosing sepsis and patient outcome, including length of stay and mortality. A total of 30 patients were enrolled in the pilot study. On admission, mean ammonia level was 35.7 μmol/L and lactic acid was 3.06 mmole/L. Ammonia levels checked at the end of day 2 (ammonia 2-4) and the beginning of day 3 (ammonia 3-1) were higher in patients who had a microbial culture-proven sepsis (p-values 0.029 and 0.002, respectively) compared to those without culture-positive sepsis. Ammonia levels did predict a longer hospital stay; ammonia level of more than 40 μmol/L had a mean hospital stay of 17.6 days vs. patients with normal levels who had a mean hospital stay of 9.62 days (p-value 0.0082). Conclusion: Elevated ammonia level can be a novel biomarker for sepsis, comparable to conventional markers. Ammonia levels have a prognostic utility as elevated levels were associated with longer hospital stay.
A Potential Role for MMPs during the Formation of Non-Neurogenic Placodes
Authors: Drake Paige M. , Franz-Odendaal Tamara A.
Published: July 2018

The formation of non-neurogenic placodes is critical prior to the development of several epithelial derivatives (e.g., feathers, teeth, etc.) and their development frequently involves morphogenetic proteins (or morphogens). Matrix metalloproteinases (MMPs) are important enzymes involved in extracellular matrix remodeling, and recent research has shown that the extracellular matrix (ECM) can modulate morphogen diffusion and cell behaviors. This review summarizes the known roles of MMPs during the development of non-neurogenic structures that involve a placodal stage. Specifically, we discuss feather, hair, tooth, mammary gland and lens development. This review highlights the potential critical role MMPs may play during placode formation in these systems.
Evaluation of Wear Phenomena of Journal Bearings by Close to Component Testing and Application of a Numerical Wear Assessment
Authors: Bergmann Philipp , Grün Florian , Summer Florian , Gódor István
Published: July 2018

Hydrodynamic journal bearings are subjected to progressively rough loading conditions leading to an increased share of operation in mixed and boundary lubrication. This results in increased frictional losses, additional wear and a higher chance of failure, which calls for the understanding of wear processes and the necessity of a numerical assessment. We conducted wear investigations of journal bearings by making use of a close-to-component test setting, and the progress of wear could be linked to the introduced frictional energy and in combination with a comprehensive surface analysis tribological effects could be resolved in detail. Achieved wear coefficients were implemented in a novelly developed numerical framework, which allows for the dynamic numerical evaluation of operation in the fluid and mixed lubrication regime and simultaneously occurring wear processes. By comparing numerical and experimental results, we evaluated the numerical framework’s capability to conduct holistic simulations including aspects like dynamically changing operation conditions, fluid and mixed lubrication as well as wear.
Synthesis and Plasmonic Chiroptical Studies of Sodium Deoxycholate Modified Silver Nanoparticles
Authors: Wang Jing , Fei Kai-Xuan , Yang Xin , Zhang Shuai-Shuai , Peng Yin-Xian
Published: July 2018

Sodium deoxycholate modified silver nanoparticles prepared in the presence of sodium deoxycholate as a chiral inducer exhibit plasmonic circular dichroism (CD) signals. The plasmon-induced chirality arises from the presence of chiral molecules (sodium deoxycholate) on the surface of Ag nanoparticles, which transfer their chiral properties to the visible wavelength range due to the Coulomb interactions between the chiral molecules and plasmonic nanoparticles. The prepared Ag nanoparticles (NPs) exhibit distinct line shapes of plasmonic CD, which can be tailored by varying the pH values of the solutions. A mechanism was proposed to explain the generation of the distinct plasmonic CD shapes, which indicated that the arrangements of chiral molecules in the plasmonic hot spots between Ag NPs are crucial for the induced plasmonic CD.
Role of Chemical Composition in Corrosion of Aluminum Alloys
Authors: Kuchariková Lenka , Liptáková Tatiana , Tillová Eva , Kajánek Daniel , Schmidová Eva
Published: July 2018

Aluminum alloys are the most important part of all shaped castings manufactured, especially in the aerospace and automotive industries. This work focuses on the corrosion properties of the heat-hardening aluminum alloys commonly used for production of automotive castings AlSi7Mg0.3 and on self-hardening AlZn10Si8Mg. Iron is a common impurity in aluminum cast alloy and its content increases by using secondary aluminum alloys. Therefore, experimental materials were developed, with chemical composition according to standards (primary alloys) and in states with an increasing content of Fe. The experimental aluminum alloys are briefly discussed in terms of their chemical composition, microstructure, mechanical properties and corrosion behavior. Corrosion properties were examined using three types of corrosion tests: exposure test, potentiodynamic tests, and Audi tests. Corrosion characteristics of materials were evaluated using stereo, optical and scanning electron microscopy, energy dispersive X-ray analysis, too. Correlation of pit initiation sites with microstructural features revealed the critical role of iron-rich phases, silicon particles and corresponding alloy matrix.
PCBN Performance in High Speed Finishing Turning of Inconel 718
Authors: Díaz-Álvarez José , Criado Víctor , Miguélez Henar , Cantero José Luis
Published: July 2018

Inconel 718 is a Ni superalloy widely used in high responsibility components requiring excellent mechanical properties at high temperature and elevated corrosion resistance. Inconel 718 is a difficult to cut material due to the elevated temperature generated during cutting, its low thermal conductivity, and the strong abrasive tool wear during cutting process. Finishing operations should ensure surface integrity of the component commonly requiring the use of hard metal tools with sharp tool edges and moderate cutting speeds. Polycrystalline cubic boron nitride (PCBN) tools recently developed an enhanced toughness suitable for these final operations. This paper focuses on the study of PCBN tools performance in finishing turning of Inconel 718. Several inserts representative of different manufacturers were tested and compared to a reference carbide tool. The evolution of tool wear, surface roughness, and cutting forces was analyzed and discussed. PCBN tools demonstrated their suitability for finishing operations, presenting reasonable removal rates and surface quality.
Oregano Essential Oil Attenuates RAW264.7 Cells from Lipopolysaccharide-Induced Inflammatory Response through Regulating NADPH Oxidase Activation-Driven Oxidative Stress
Authors: Cheng Chuanshang , Zou Yi , Peng Jian
Published: July 2018

Oregano is an aromatic plant widely distributed throughout the Mediterranean area and in Asia. Recent studies have revealed that the anti-inflammatory effect of essential oil in this plant. However, the mechanisms underlying the therapeutic potential have not been well elucidated. This study determined whether oregano essential oil (OEO) exerts an anti-inflammatory effect on lipopolysaccharide (LPS)-treated murine macrophage cells (RAW264.7 cells) in vitro and elucidated the possible underlying molecular mechanisms. The results showed that OEO (2.5–10 μg/mL) inhibited the expression and secretion of interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) in RAW264.7 cells treated with LPS (1 μg/mL). Consistent with the pro-inflammatory gene expression, the OEO treatment efficiently reduced the LPS-induced activation of mitogen-activated protein kinase, protein kinase B, and nuclear factor κB in RAW264.7 cells. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibition in Nox2 protein-silenced cells attenuated the mRNA expression of IL-1β, IL-6, and TNF-α in the LPS-induced RAW264.7 cells. The OEO inhibited the LPS-induced elevation of NADPH oxidase and oxidative stress. This result suggests that LPS induces RAW264.7 cell inflammation through the NADPH oxidase-mediated production of reactive oxygen species (ROS). In conclusion, OEO protects against the LPS-induced RAW264.7 cell inflammatory response through the NADPH oxidase/ROS pathway.
HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence
Authors: Zhao Xue Zhi , Métifiot Mathieu , Kiselev Evgeny , Kessl Jacques J. , Maddali Kasthuraiah , Marchand Christophe , Kvaratskhelia Mamuka , Pommier Yves , Burke Terrence R.
Published: July 2018

HIV-1 integrase (IN) inhibitors represent a new class of highly effective anti-AIDS therapeutics. Current FDA-approved IN strand transfer inhibitors (INSTIs) share a common mechanism of action that involves chelation of catalytic divalent metal ions. However, the emergence of IN mutants having reduced sensitivity to these inhibitors underlies efforts to derive agents that antagonize IN function by alternate mechanisms. Integrase along with the 96-residue multifunctional accessory protein, viral protein R (Vpr), are both components of the HIV-1 pre-integration complex (PIC). Coordinated interactions within the PIC are important for viral replication. Herein, we report a 7-mer peptide based on the shortened Vpr (69–75) sequence containing a biotin group and a photo-reactive benzoylphenylalanyl residue, and which exhibits low micromolar IN inhibitory potency. Photo-crosslinking experiments have indicated that the peptide directly binds IN. The peptide does not interfere with IN-DNA interactions or induce higher-order, aberrant IN multimerization, suggesting a mode of action for the peptide that is distinct from clinically used INSTIs and developmental allosteric IN inhibitors. This compact Vpr-derived peptide may serve as a valuable pharmacological tool to identify a potential new pharmacologic site.
Utilization of Flavonoid Compounds from Bark and Wood. III. Application in Health Foods
Authors: Ogawa Sosuke , Matsuo Yosuke , Tanaka Takashi , Yazaki Yoshikazu
Published: July 2018

Dietary supplements ACAPOLIA® and ACAPOLIA PLUS have been sold in Japan under the classification “Foods in General” for a number of years. In April 2015, the classification of “Foods with Function Claims” was introduced in Japan to make more products available to the public that were clearly labeled with functional claims based on scientific evidence. In order to obtain recognition of ACAPOLIA PLUS under this new classification, the following information needed to be established. The safety of the bark extract of Acacia mearnsii was shown from the history of the long-term safe consumption of the extract as a health supplement, together with several additional clinical safety tests. Robinetinidol-(4α,8)-catechin was detected by high performance liquid chromatography (HPLC) in the supplement and was suitable for use as the basis of the quantitative analysis. In clinical tests, the amount of change in the plasma glucose concentration in the initial 60 min after rice consumption by a test group who had been given the Acadia extract was significantly lower than the glucose concentration in the group that was given a placebo. The blood glucose incremental areas under the curve (IAUC) in the first 60 min after rice consumption were also significantly lower in the Acacia group. The functional mechanisms were explained in terms of the inhibition of the absorption of glucose in the small intestine and the reduction in the activity of the digestive enzymes caused by proanthocyanidins derived from A. mearnsii bark. As a result, ACAPOLIA PLUS was accepted as a “Food with Function Claims” in August 2016. ACAPOLIA PLUS is now sold under this new classification. The growth of a typical intestinal bacterium is inhibited by an extract containing flavonoid compounds from A. mearnsii bark; thus, one of the future directions of study must be a comprehensive investigation of the effect that flavonoid compounds, proanthocyanidins, have on intestinal bacteria.
Optimization of Flavonoid Extraction from Red and Brown Rice Bran and Evaluation of the Antioxidant Properties
Authors: Ghasemzadeh Ali , Baghdadi Ali , Z. E. Jaafar Hawa , Swamy Mallappa Kumara , Megat Wahab Puteri Edaroyati
Published: July 2018

Recently, the quality-by-design concept has been widely implemented in the optimization of pharmaceutical processes to improve batch-to-batch consistency. As flavonoid compounds in pigmented rice bran may provide natural antioxidants, extraction of flavonoid components from red and brown rice bran was optimized using central composite design (CCD) and response surface methodology (RSM). Among the solvents tested, ethanol was most efficient for extracting flavonoids from rice bran. The examined parameters were temperature, solvent percentage, extraction time, and solvent-to-solid ratio. The highest total flavonoid content (TFC) in red rice bran was predicted as 958.14 mg quercetin equivalents (QE)/100 g dry matter (DM) at 58.5 °C, 71.5% (v/v), 36.2 min, and 7.94 mL/g, respectively, whereas the highest TFC in brown rice bran was predicted as 782.52 mg QE/100 g DM at 56.7 °C, 74.4% (v/v), 36.9 min, and 7.18 mL/g, respectively. Verification experiment results under these optimized conditions showed that the TFC values for red and brown rice bran were 962.38 and 788.21 mg QE/100 g DM, respectively. No significant differences were observed between the predicted and experimental TFC values, indicating that the developed models are accurate. Analysis of the extracts showed that apigenin and p-coumaric acid are abundant in red and brown rice bran. Further, red rice bran with its higher flavonoid content exhibited higher nitric oxide and 2,2-diphenyl-1-picrylhydrazyl scavenging activities (EC50 values of 41.3 and 33.6 μg/mL, respectively) than brown rice bran. In this study, an extraction process for flavonoid compounds from red and brown rice bran was successfully optimized. The accuracy of the developed models indicated that the approach is applicable to larger-scale extraction processes.
Sensory Characteristics of Combinations of Phenolic Compounds Potentially Associated with Smoked Aroma in Foods
Authors: Wang Hongwei , Chambers Edgar , Kan Jianquan
Published: July 2018

The sensory characteristics of phenolic compounds combinations were evaluated. A highly trained descriptive panel evaluated combinations of chemicals (two chemicals at a time) containing either one smoky aroma and one non-smoky aroma chemical compound, two smoky aroma chemicals, or two non-smoky aroma chemicals. The non-smoky compounds had been associated with smoke aroma in other studies, but were not found to be smoky when tested individually. Smoked flavor characteristics and intensities were changed significantly when two phenolic compounds were combined. Non-smoky phenolic compounds often contributed the smoked flavor when combined with one smoky phenolic compound or another non-smoky phenolic compound. It is necessary to understand the sensory characteristics of compound combinations as well as individual compounds.
High-Throughput Analysis of Selected Urinary Hydroxy Polycyclic Aromatic Hydrocarbons by an Innovative Automated Solid-Phase Microextraction
Authors: Dugheri Stefano , Bonari Alessandro , Gentili Matteo , Cappelli Giovanni , Pompilio Ilenia , Bossi Costanza , Arcangeli Giulio , Campagna Marcello , Mucci Nicola
Published: July 2018

High-throughput screening of samples is the strategy of choice to detect occupational exposure biomarkers, yet it requires a user-friendly apparatus that gives relatively prompt results while ensuring high degrees of selectivity, precision, accuracy and automation, particularly in the preparation process. Miniaturization has attracted much attention in analytical chemistry and has driven solvent and sample savings as easier automation, the latter thanks to the introduction on the market of the three axis autosampler. In light of the above, this contribution describes a novel user-friendly solid-phase microextraction (SPME) off- and on-line platform coupled with gas chromatography and triple quadrupole-mass spectrometry to determine urinary metabolites of polycyclic aromatic hydrocarbons 1- and 2-hydroxy-naphthalene, 9-hydroxy-phenanthrene, 1-hydroxy-pyrene, 3- and 9-hydroxy-benzoantracene, and 3-hydroxy-benzo[a]pyrene. In this new procedure, chromatography’s sensitivity is combined with the user-friendliness of N-tert-butyldimethylsilyl-N-methyltrifluoroacetamide on-fiber SPME derivatization using direct immersion sampling; moreover, specific isotope-labelled internal standards provide quantitative accuracy. The detection limits for the seven OH-PAHs ranged from 0.25 to 4.52 ng/L. Intra-(from 2.5 to 3.0%) and inter-session (from 2.4 to 3.9%) repeatability was also evaluated. This method serves to identify suitable risk-control strategies for occupational hygiene conservation programs.
Medium-Chain Triglycerides Lower Blood Lipids and Body Weight in Streptozotocin-Induced Type 2 Diabetes Rats
Authors: Sung Ming-Hua , Liao Fang-Hsuean , Chien Yi-Wen
Published: July 2018

Medium-chain triglycerides (MCTs) are distinguished from other triglycerides in that each fat molecule consists of 6 to 12 carbons in length. MCTs and long-chain triglycerides (LCTs) are absorbed and utilized in different ways. The aim of this study was to assess the effects of replacing soybean oil with MCT oil, in a low- or high-fat diet, on lipid metabolism in rats with streptozotocin-induced type 2 diabetes mellitus (T2DM). There were, thirty-two T2DM Sprague-Dawley rats divided into low-fat-soybean oil (LS), low-fat-MCT oil (LM), high-fat-soybean oil (HS), and high-fat-MCT oil (HM) groups. After 8 weeks, blood sugar, serum lipids, liver lipids, and enzyme activities related to lipid metabolism were measured. Under a high-fat diet condition, replacement of soybean oil with MCT oil lowered serum low-density lipoprotein cholesterol (LDL-C), non-esterified fatty acids, and liver total cholesterol; whilst it increased serum high-density lipoprotein cholesterol (HDL-C) and the HDL-C/LDL-C ratio. A low-fat diet with MCT oil resulted in lower body weight and reproductive white adipose tissues compared to the HS groups, and higher hepatic acyl-CoA oxidase activities (the key enzyme in the peroxisomal beta-oxidation) compared to the LS group in T2DM rats. In conclusion, MCTs showed more protective effects on cardiovascular health in T2DM rats fed a high-fat diet, by improving serum lipid profiles and reducing hepatic total cholesterol.
Beneficial Pharmacokinetic Drug Interactions: A Tool to Improve the Bioavailability of Poorly Permeable Drugs
Authors: Gerber Werner , Steyn Johan D. , Kotzé Awie F. , Hamman Josias H.
Published: July 2018

Simultaneous oral intake of herbs, supplements, foods and drugs with other drug(s) may result in pharmacokinetic or pharmacodynamic interactions with the latter. Although these interactions are often associated with unwanted effects such as adverse events or inefficacy, they can also produce effects that are potentially beneficial to the patient. Beneficial pharmacokinetic interactions include the improvement of the bioavailability of a drug (i.e., by enhancing absorption and/or inhibiting metabolism) or prolongation of a drug’s plasma level within its therapeutic window (i.e., by decreasing excretion), whereas beneficial pharmacodynamic interactions include additive or synergistic effects. Mechanisms by which pharmacokinetic interactions can cause beneficial effects include enhancement of membrane permeation (e.g., structural changes in the epithelial cell membranes or opening of tight junctions), modulation of carrier proteins (e.g., inhibition of efflux transporters and stimulation of uptake transporters) and inhibition of metabolic enzymes. In the current review, selected pharmacokinetic interactions between drugs and various compounds from different sources including food, herb, dietary supplements and selected drugs are discussed. These interactions may be exploited in the future to the benefit of the patient, for example, by delivering drugs that are poorly bioavailable in therapeutic levels via alternative routes of administration than parenteral injection.
A Cyclic Nucleotide-Gated Channel, HvCNGC2-3, Is Activated by the Co-Presence of Na+ and K+ and Permeable to Na+ and K+ Non-Selectively
Authors: Mori Izumi C. , Nobukiyo Yuichi , Nakahara Yoshiki , Shibasaka Mineo , Furuichi Takuya , Katsuhara Maki
Published: July 2018

Cyclic nucleotide-gated channels (CNGCs) have been postulated to contribute significantly in plant development and stress resistance. However, their electrophysiological properties remain poorly understood. Here, we characterized barley CNGC2-3 (HvCNGC2-3) by the two-electrode voltage-clamp technique in the Xenopus laevis oocyte heterologous expression system. Current was not observed in X. laevis oocytes injected with HvCNGC2-3 complementary RNA (cRNA) in a bathing solution containing either Na+ or K+ solely, even in the presence of 8-bromoadenosine 3′,5′-cyclic monophosphate (8Br-cAMP) or 8-bromoguanosine 3′,5′-cyclic monophosphate (8Br-cGMP). A weakly voltage-dependent slow hyperpolarization-activated ion current was observed in the co-presence of Na+ and K+ in the bathing solution and in the presence of 10 µM 8Br-cAMP, but not 8Br-cGMP. Permeability ratios of HvCNGC2-3 to K+, Na+ and Cl− were determined as 1:0.63:0.03 according to reversal-potential analyses. Amino-acid replacement of the unique ion-selective motif of HvCNGC2-3, AQGL, with the canonical motif, GQGL, resulted in the abolition of the current. This study reports a unique two-ion-dependent activation characteristic of the barley CNGC, HvCNGC2-3.
Influence of Two Polymer-Based Superplasticizers (Poly-naphthalene Sulfonate, PNS, and Lignosulfonate, LS) on Compressive and Flexural Strength, Freeze-Thaw, and Sulphate Attack Resistance of Lime-Metakaolin Grouts
Authors: Duran Adrián , González-Sánchez Jesús F. , Fernández José M. , Sirera Rafael , Navarro-Blasco Íñigo , Alvarez José I.
Published: July 2018

A new range of grouts prepared by air lime and metakaolin (MK) as a pozzolanic admixture has been obtained by using as dispersing agents two polymers, namely poly-naphthalene sulfonate (PNS) and lignosulfonate (LS), with the aim of improving the fluidity of the fresh grouts. Fluidity and setting times of the grouts were assessed. Differences in the molecular architecture and in the anionic charge density explained the different adsorption of the polymers and the different performance. The higher anionic charge of PNS and its linear shape explained its better adsorption and effectiveness. The pozzolanic reaction was favoured in grouts with PNS, achieving the highest values of compressive strength (4.8 MPa after 182 curing days). The addition of PNS on lime grouts slightly decreased the frost resistance of the grouts (from 24 freeze-thaw cycles for the polymer-free samples to 19 or 20 cycles with 0.5 or 1 wt % of PNS). After the magnesium sulphate attack, grouts were altered by decalcification of hydrated phases and by formation of hexahydrite and gypsum. A protective role of portlandite against magnesium sulphate attack was clearly identified. Accordingly, the polymer LS, which preserves a significant amount of Ca(OH)2, could be an alternative for the obtaining of grouts requiring high sulphate attack resistance.
The Role of Immune Response in Optimal HIV Treatment Interventions
Authors: Toro-Zapata Hernán , Caicedo-Casso Angélica , Lee Sunmi
Published: July 2018

A mathematical model for the transmission dynamics of human immunodeficiency virus (HIV) within a host is developed. Our model focuses on the roles of immune response cells or cytotoxic lymphocytes (CTLs). The model includes active and inactive cytotoxic immune cells. The basic reproduction number and the global stability of the virus free equilibrium is carried out. The model is modified to include anti-retroviral treatment interventions and the controlled reproduction number is explored. Their effects on the HIV infection dynamics are investigated. Two different disease stage scenarios are assessed: early-stage and advanced-stage of the disease. Furthermore, optimal control theory is employed to enhance healthy CD4+ T cells, active cytotoxic immune cells and minimize the total cost of anti-retroviral treatment interventions. Two different anti-retroviral treatment interventions (RTI and PI) are incorporated. The results highlight the key roles of cytotoxic immune response in the HIV infection dynamics and corresponding optimal treatment strategies. It turns out that the combined control (both RTI and PI) and stronger immune response is the best intervention to maximize healthy CD4+ T cells at a minimal cost of treatments.
Relative Pose Based Redundancy Removal: Collaborative RGB-D Data Transmission in Mobile Visual Sensor Networks
Authors: Wang Xiaoqin , Şekercioğlu Y. Ahmet , Drummond Tom , Frémont Vincent , Natalizio Enrico , Fantoni Isabelle
Published: July 2018

In this paper, the Relative Pose based Redundancy Removal (RPRR) scheme is presented, which has been designed for mobile RGB-D sensor networks operating under bandwidth-constrained operational scenarios. The scheme considers a multiview scenario in which pairs of sensors observe the same scene from different viewpoints, and detect the redundant visual and depth information to prevent their transmission leading to a significant improvement in wireless channel usage efficiency and power savings. We envisage applications in which the environment is static, and rapid 3D mapping of an enclosed area of interest is required, such as disaster recovery and support operations after earthquakes or industrial accidents. Experimental results show that wireless channel utilization is improved by 250% and battery consumption is halved when the RPRR scheme is used instead of sending the sensor images independently.
Smart Portable Devices Suitable for Cultural Heritage: A Review
Authors: Valentini Federica , Calcaterra Andrea , Antonaroli Simonetta , Talamo Maurizio
Published: July 2018

This article reviews recent portable sensor technologies to apply in the Cultural Heritage (CH) fields. The review has been prepared in the form of a retrospective description of the sensor’s history and technological evolution, having: new nanomaterials for transducers, miniaturized, portable and integrated sensors, the wireless transmission of the analytical signals, ICT_Information Communication Technology and IoT_Internet of Things to apply to the cultural heritage field. In addition, a new trend of movable tattoo sensors devices is discussed, referred to in situ analysis, which is especially important when scientists are in the presence of un-movable and un-tangible Cultural Heritage and Art Work objects. The new proposed portable contact sensors (directly applied to art work objects and surfaces) are non-invasive and non-destructive to the different materials and surfaces of which cultural heritage is composed.
Bio-Inspired Covert Active Sonar Strategy
Authors: Jiang Jiajia , Wang Xianquan , Duan Fajie , Li Chunyue , Fu Xiao , Huang Tingting , Bu Lingran , Ma Ling , Sun Zhongbo
Published: July 2018

The covertness of the active sonar is a very important issue and the sonar signal waveform design problem was studied to improve covertness of the system. Many marine mammals produce call pulses for communication and echolocation, and existing interception systems normally classify these biological signals as ocean noise and filter them out. Based on this, a bio-inspired covert active sonar strategy was proposed. The true, rather than man-made sperm whale, call pulses were used to serve as sonar waveforms so as to ensure the camouflage ability of sonar waveforms. A range and velocity measurement combination (RVMC) was designed by using two true sperm whale call pulses which had excellent range resolution (RR) and large Doppler tolerance (DT). The range and velocity estimation methods were developed based on the RVMC. In the sonar receiver, the correlation technology was used to confirm the start and end time of sonar signals and their echoes, and then based on the developed range and velocity estimation method, the range and velocity of the underwater target were obtained. Then, the RVMC was embedded into the true sperm whale call-train to improve the camouflage ability of the sonar signal-train. Finally, experiment results were provided to verify the performance of the proposed method.
Effects of Probiotic (Bacillus subtilis DE111) Supplementation on Immune Function, Hormonal Status, and Physical Performance in Division I Baseball Players
Authors: Townsend Jeremy R. , Bender David , Vantrease William C. , Sapp Philip A. , Toy Ann M. , Woods Clint A. , Johnson Kent D.
Published: July 2018

We sought to determine the effects of probiotic supplementation (Bacillus subtilis DE111; 1 billion CFU∙d−1) on markers of immune and hormonal status in collegiate male athletes following 12 weeks of offseason training. Twenty-five Division I male baseball athletes (20.1 ± 1.5 years, 85.5 ± 10.5 kg, 184.7 ± 6.3 cm) participated in this double blind, placebo-controlled, randomized study. Participants were randomly assigned to a probiotic (PRO; n = 13) or placebo (PL; n = 12) group. Pre- and post-training, all athletes provided resting blood and saliva samples. Circulating concentrations of testosterone, cortisol, TNF-α, IL-10, and zonulin were examined in the blood, while salivary immunoglobulin A (SIgA) and SIgM were assayed as indicators of mucosal immunity. Separate analyses of covariance (ANCOVA) were performed on all measures collected post intervention. No differences in measures of body composition or physical performance were seen between groups. TNF-α concentrations were significantly (p = 0.024) lower in PRO compared to PL, while there were no significant group differences in any other biochemical markers examined. A main effect for time was observed (p < 0.05) for increased testosterone (p = 0.045), IL-10 (p = 0.048), SIgA rate (p = 0.031), and SIgM rate (p = 0.002) following offseason training. These data indicate that probiotic supplementation had no effect on body composition, performance, hormonal status, or gut permeability, while it may attenuate circulating TNF-α in athletes.
Facilitating Change for Climate-Smart Agriculture through Science-Policy Engagement
Authors: Dinesh Dhanush , Zougmore Robert , Vervoort Joost , Totin Edmond , Thornton Philip , Solomon Dawit , Shirsath Paresh , Pede Valerien , Lopez Noriega Isabel , Läderach Peter , Körner Jana , Hegger Dries , Girvetz Evan , Friis Anette , Driessen Peter , Campbell Bruce
Published: July 2018

Climate change impacts on agriculture have become evident, and threaten the achievement of global food security. On the other hand, the agricultural sector itself is a cause of climate change, and if actions are not taken, the sector might impede the achievement of global climate goals. Science-policy engagement efforts are crucial to ensure that scientific findings from agricultural research for development inform actions of governments, private sector, non-governmental organizations (NGOs) and international development partners, accelerating progress toward global goals. However, knowledge gaps on what works limit progress. In this paper, we analyzed 34 case studies of science-policy engagement efforts, drawn from six years of agricultural research for development efforts around climate-smart agriculture by the CGIAR Research Program on Climate Change, Agriculture and Food Security (CCAFS). Based on lessons derived from these case studies, we critically assessed and refined the program theory of the CCAFS program, leading to a revised and improved program theory for science-policy engagement for agriculture research for development under climate change. This program theory offers a pragmatic pathway to enhance credibility, salience and legitimacy of research, which relies on engagement (participatory and demand-driven research processes), evidence (building scientific credibility while adopting an opportunistic and flexible approach) and outreach (effective communication and capacity building).
Economic Transition and Changing Location of Manufacturing Industry in China: A Study of the Yangtze River Delta
Authors: Wu Jiawei , Wei Yehua Dennis , Li Qizhai , Yuan Feng
Published: July 2018

Industrial restructuring is widely considered an important force in regional economic growth and sustainable development. With increased globalization and economic transition, a dramatic industrial restructuring has been taking place in China. Applying geographically weighted shift-share model (GW-SSM) and geographically and temporally weighted regression model (GTWR), we analyze (re)location dynamics and determinants of the manufacturing industry in the Yangtze River Delta (YRD) from 1999 to 2013, with particular attention to the implications of economic transition and institutional restructuring. We find that high-tech and capital-intensive manufacturing industries agglomerated in coastal cities, while labor-intensive and resource-based sectors have become spatially more dispersed to peripheral areas. We also find that the development of service and high-tech industries, rising labor costs, and more strict environmental regulations have facilitated the geographic dispersion of labor- and pollution-intensive industries. Moreover, regions with advantages in intermediate goods, preferential policies, and urbanization economies are attractive to capital- and technology-intensive manufacturing industries. Our research suggests that development policies should be tailored to specific regions to promote local production and innovative networks and make manufacturing industries more competitive.