bluuebunny/crossref_metadata_2025 huggingface dataset:
A percepção da intertextualidade pelos alunos do ensino fundamental, nas aulas de Língua Portuguesa: diálogo entre poema e vídeo
Authors: Almeida Regislene Dias de
Published: July 2020

Este artigo pretende apresentar o trabalho realizado durante as aulas de Língua Portuguesa, com alunos dos nonos anos do ensino fundamental, de uma escola municipal, no interior de São Paulo, sobre a análise da intertextualidade presente na apropriação de um texto literário para um produto audiovisual. Os objetos selecionados para o desenvolvimento do trabalho constituem-se do poema “Quadrilha”, de Carlos Drummond de Andrade e do episódio homônimo, da série “Tudo o que é sólido pode derreter”, dos diretores Rafael Gomes e Esmir Filho, com roteiro de Mariana Bastos. A análise se dará de forma a considerar a percepção que os alunos tiveram, ao analisar as relações entre o poema e o vídeo, numa perspectiva de texto multimodal e multissemiótico.
Distribuição da lateral /l/ em coda no português santomense
Authors: Balduino Amanda Macedo , Vieira Nancy Mendes Torres
Published: July 2020

O português santomense (PST) é uma das variedades do português faladas em São Tomé e Príncipe e compartilha características estruturais com o português brasileiro (PB), com o português europeu (PE), além de apresentar características intrínsecas, evidenciadas pela distribuição da lateral em coda que, a exemplo do PB e do PE, pode ser produzida como [ɫ] ou [w]. Este artigo tem como objetivo descrever a distribuição de /l/ em coda no PST, bem como analisar os processos de velarização [ɫ] e vocalização [w] nesta variedade. Foi constatada a produção de [ɫ] em 49,87% dos dados e de [w] em 19,1%, sendo a forma vocalizada favorecida quando a vogal anterior era [dorsal].
O gênero fanfiction: análise intergenérica da escrita de fãs
Authors: Sousa Karen Dias de
Published: July 2020

Este artigo pretende demonstrar os resultados de uma pesquisa que analisou textos publicados em uma plataforma on-line de fanfics, narrativas criadas por fã da cultura pop japonesa. A análise utilizou-se principalmente do conceito de “relações intergenéricas” e da noção de “ruína” (CORRÊA, 2006) para investigar com quais gêneros, esferas e semioses as fanfics dialogam.
A terminologia do domínio do ciclismo no Brasil: casos de variação entre os termos que denominam as partes principais da bicicleta de estrada
Authors: Molinari Milena de Paula , Babini Maurizio
Published: July 2020

O objetivo principal deste trabalho consiste em analisar a terminologia do domínio do ciclismo de estrada veiculada por manuais desse tipo de veículo difundidos no Brasil, refletindo, especificamente, sobre as variantes dos termos denominativos das partes principais da bicicleta de estrada encontradas nesse tipo de documento. Para tanto, adotamos os princípios teóricos e metodológicos da Teoria Comunicativa da Terminologia (CABRÉ, 1999) e também nos baseamos nos critérios propostos por Faulstich (1997, 2001) para estabelecer as variantes terminológicas. Dentre os principais resultados obtidos, destacamos a presença de 7 casos de variantes lexicais e 22 de variantes geográficas. Com base nesses dados, verificamos que muitos manuais divulgados no Brasil por empresas europeias foram traduzidos para o português de Portugal, o que nos levou a encontrar um grande número de variantes geográficas em nossas análises, uma vez que partimos do português do Brasil. Com este estudo, esperamos, então, que possamos contribuir com uma melhor comunicação nessa área, sobretudo, no contexto brasileiro.
Proposta lexicográfica para verbetes de dicionário especial de homônimos da Língua Brasileira de Sinais – Libras
Authors: Leôncio Érika Lourrane
Published: July 2020

Apoiados em Haensh (1982), Biderman (1978, 1984, 1992); Carballo (2003), Ullmann (1964), Liddell e Johnson (1989), Faria-do-Nascimento (2009), desenvolvemos uma proposta de verbete para o registro, em dicionário especial, de itens lexicais homonímicos da Língua Brasileira de Sinais – Libras. Nosso propósito foi desenvolver um modelo de verbete capaz de registrar e sistematizar a ocorrência da homonímia e seus usos na libras. Para exemplificar o modelo, apresentamos, neste artigo, cinco verbetes para as formas homônimas dos sinais SÁBADO, MÃE, MINUTO, DIREITO, BAHIA. Na proposta, optamos pela ordenação semasiológica, baseada no princípio de ordenação paramétrica, as informações selecionadas para o Programa Constante de Informações (PCI) foram as de ordem: (i) gramatical (classificação gramatical); (ii) semântica (definição, sinônimos); (iii) sintática (exemplos de uso) e (iv) pragmáticas (área do conhecimento, regionalismo).
Aspectos mórfico-sintáticos e a funcionalidade do artigo como construtor do texto
Authors: Salzedas Nelyse Apparecida Melro , Paccola Rivaldo Alfredo
Published: July 2020

O artigo é, dentre as categorias gramaticais, uma das mais expressivas, porém nem sempre explorado. Alguns autores tiram-no da passividade e dão-lhe um tom aguerrido e múltiplo. A presença do artigo definido traz reforço aos nomes abstratos pluralizados, acentuando-lhes a vaguidade; assim como sua omissão esvazia as arestas de nomes concretos, gerando sigmatização. O artigo cria também uma função rítmica e tem um papel intensificante em nível entoativo, uma vez que o acento tonal reforça o conteúdo substantivo. E um texto produzido por meio de uma pontuação lógica, ausente o sistema afetivo, traduz tons afetivos, tons intensivos, se manipuladas habilmente as estruturas mórfico-sintáticas. Sob a luz dos estudos de Macambira (1974), Cressot (1969), Borba (1971), Brik (1978), Paiva (1961), Pimpão (1942), propomos discutir o uso e a função do artigo sob o ponto de vista mórfico e sintático bem como sua funcionalidade dentro do texto: a superlativação, a enfatização, a entoação. Assim, a carta Ao Sr. E. Mollinet, na Correspondência de Fradique Mendes, de Eça de Queiroz (s/d), serviu de contexto para aplicação da teoria arrolada, posto que o uso eciano do artigo contextualiza situações que indicam as condições destacadas.
Enunciados de estilo telegráfico nas afasias: funcionamento linguístico-cognitivo sob uma visão integrada dos níveis linguísticos
Authors: Lima Arnaldo Rodrigues de
Published: July 2020

A ausência e/ou substituição de palavras e morfemas considerados puramente gramaticais é o sinal que, tradicionalmente, define a chamada “fala telegráfica”. A instabilidade com os recursos gramaticais pode ser compreendida, a depender da teoria, como consequência direta de déficits específicos em cada um dos níveis linguísticos. O principal objetivo deste trabalho é desenvolver uma reflexão sobre o funcionamento gramatical destacando, sobretudo, o imbricamento dos níveis linguísticos e, por fim, ressaltar a necessidade de se considerar esse imbricamento na compreensão dos fenômenos linguístico-cognitivos, principalmente aqueles relacionados à produção de sujeitos afásicos considerados não-fluentes. A reflexão fundamenta-se na Neuropsicologia sócio-histórico-cultural, nos pressupostos teórico-metodológicos da Neurolinguística enunciativo-discursiva e na Gramática Funcional do Discurso.
Ênfases no ensino de escrita: tema, estilo e construção composicional em livros escolares de português
Authors: Imbruniz Cristian Henrique
Published: July 2020

Este trabalho apresenta a análise de propostas de escrita de dezesseis livros escolares de português publicados no período de 1930 a 2002, no Brasil. Descartando qualquer suposição de que a noção de gênero do discurso (BAKHTIN, 2016) tenha sido mobilizada como instrumento didático naqueles livros, as propostas são descritas com base no conteúdo temático, no estilo e na construção composicional, elementos do gênero de discurso utilizados como ferramentas teórico-metodológicas, aqui apresentadas na análise do livro Português para o ginásio, de Cretela (1948). O objetivo do trabalho foi determinar qual desses elementos é o mais enfatizado nos livros do período. Os resultados indicam que, entre 1930 e 1960, predominou a ênfase no conteúdo temático e, a partir de 1970, na construção composicional.
A filosofia da linguagem bakhtiniana e sua tridimensionalidade verbivocovisual
Authors: De Paula Luciane , Luciano José Antonio Rodrigues
Published: July 2020

Este artigo tem por escopo compreender a concepção de linguagem proposta na elaboração da filosofia da linguagem bakhtiniana, em especial, a partir das obras de Bakhtin, ECV (2011); de Medviédev, MFEL (2012); e de Volóchinov, MFL (2017). A hipótese apresentada é a de que, para pensar a relação entre sujeito e signo, o Círculo utilizou-se da palavra, entendida de forma alargada, isto é, como linguagem tridimensional, a qual Paula cunhou verbivocovisual, uma vez que se articula e realiza-se na interrelação das dimensões verbal (semântica), vocal (sonora) e visual (imagética). Para o desenvolvimento deste estudo, utilizamos o método dialético-dialético (PAULA, FIGUEIREDO, PAULA, 2011) e, por cotejo, os textos entre si e entre outras obras do Círculo, bem como entre conceitos e áreas das quais advêm, contextualizados. Com isso, além da noção de linguagem, procuramos refletir acerca da pertinência do pensamento bakhtiniano como aporte teórico para análise de enunciado visual, verbal, sonoro e/ou sincrético.
Bem Barbiezinha.... Fascista: ironia em post
Authors: Teixeira Laura Pereira
Published: July 2020

O presente trabalho propõe analisar a constituição irônica de uma imagem de mulher construída em enunciados veiculados pelas páginas intituladas “Barbie Fascista” e “Barbie e Ken Cidadãos de Bem”, do Facebook. A fundamentação teórica se baseia nos estudos bakhtinianos, sobretudo nas concepções de diálogo, linguagem, sujeito, signo e ideologia. O método dialógico de análise se pauta no cotejo com outros enunciados, de diversas esferas. O objetivo é refletir e compreender a construção enunciativa da ironia por inversão, utilizada como forma de questionamento e ridicularização de um tipo social de mulher considerada abastada e com um posicionamento político de direita, com tendências conservadoras. Os resultados se voltam à reflexão acerca das imagens de mulher construídas nessas páginas, além do papel e noção de mulher neste momento histórico. A contribuição desta proposta se volta a um estudo sobre quem é e o que é ser mulher no Brasil da era Bolsonaro.
Endothelial Nitric Oxide Synthase (eNOS) Gene Expression determine the abundance of circulatory Endothelial Progenitor Cells (EPC) in Premature Coronary Artery Disease (PCAD) Patients
Authors: Sen Atanu , Vemparala Kranthi , Roy Ambuj , Bahl Vinay Kumar , Prabhakaran Dorairaj , Sinha Subrata , Re Kolli Srinath , Ramakrishnan Lakshmy
Published: July 2020

Objectives: Several studies has reported a reduced circulatory level and impaired functionality of EPCs in coronary artery disease (CAD) patients and the role of endothelial nitric oxide Synthase (eNOS) in relation with reduced circulatory level of EPC and their impaired functionality has been revealed by in vitro and animal studies. However EPC’s eNOS gene expression profile in in vivo condition in PCAD patients is yet to be revealed as the prevalence of CAD at young age is markedly increased in developing countries. Our previous study has already reported a significantly reduced circulatory level of EPC in PCAD patients compared to control subjects and in continuation of that finding, present study aimed to investigate the eNOS gene expression of EPC in same study subjects as well as to establish the association between EPC’s eNOS gene expression and reduced circulatory level of EPC in PCAD patients. Results: Reduced eNOS gene expression in EPC from PCAD patients compared to healthy controls were found (0.998±0.096/1.063±0.107) with a p-value of 0.002 and this difference was persistent even after adjusting for confounding factors (p=0.002). A positive correlation was found between eNOS gene expression and level of EPC in circulation (r = 0.234 and p = 0.0664); data from previous study.
Co-expression network analysis identified novel potential Signature Genes Associated with human left ventricle cardiomyopathies arises from different etiologies
Authors: Tian Jiao , Wu Zhengyuan , He Yingying , LIU SHUBAI
Published: July 2020

Background: Heat disease is worldwide pandemic and brings huge healthcare burden to global society. However, it is still illusive that the whole transcription disorder pattern of cardiomyopathies arises from different etiologies. We applied Weighted Gene Co-Expression Network Analysis (WGCNA) to construct and screen functional gene significantly related to 8 subtypes of cardiomyopathies. Through co-expression and protein-protein interaction (PPI) networks enrichment analysis, the hub genes and key pathways were identified, which highly correlated with pathologic traits. Compared with expression profile of healthy group, potential disease signature genes were validated through another independently investigations of cardiomyopathies via cardiovascular disease bioportal. Results: The novel potential disease signature genes were identified and assembled into three axes that shared among five cardiomyopathies groups, including idiopathic cardiomyopathy, familial cardiomyopathy, post-partum cardiomyopathy, Ischemic cardiomyopathy and viral cardiomyopathy. Four disease signature genes (MDM4, CFLAR, RPS6KB1, PKD1L2) were shared by ischemic and ischemic cardiomyopathy group. Eight signature genes (MAPK1, MAPK11, MAPK14, LMNA, RAC1, PECAM1, XIAP, CREB1) were overlapped by Ischemic Cardiomyopathy with Post. Partum/Familiar/Idiopathic Cardiomyopathy groups. The signature genes (TFAM, RHEB) were common genes among Viral Cardiomyopathy and Post. Partum / Familiar /Idiopathic Cardiomyopathy groups. These some novel signature genes were highlighted as potential biomarkers for cardiomyopathies. The majority disorder functions and pathways enriched in metabolic processes and concentrated on MAPK signaling pathway, protein processing in endoplasmic reticulum, regulation of actin cytoskeleton pathway. Conclusion: It strongly suggests that expression disorder of these signature genes may contribute the cardiac dysregulation and relapse into cardiomyopathies. Taken together, these novel signature genes could be utilized as diagnostic biomarkers or therapy targets and benefit the precise clinical diagnostics with better outcome. In summary, this study will attract great interest of clinical research scientists as well as medical scientists that work on heart diseases.
Impact of online Internet Training on the Prevention and Control of the Novel Coronavirus Pneumonia
Authors: Wang Xiaoli , Zhang Haiyan , Xu Hongmei , Wang Yao , Wang Ping
Published: July 2020

Background

To observe the impact of online internet training on the prevention and control of the novel coronavirus pneumonia, and to supply clinical evidence for an effective safety training model for emergent public safety situations.
Methods

A total of 2,080 medical technicians of the Third People’s Hospital of Yancheng, affiliated to Southeast University, were enrolled and divided into two groups based on the training mode (online vs. routine). They were evaluated based on the rate of excellence in five aspects: medical technicians’ prevention and control, patient management, disinfection, medical waste disposal, and hand hygiene. A questionnaire was used to check the theoretical knowledge of both groups of the prevention and control of the new coronavirus pneumonia.
Results

The online training group had a higher excellence rate for medical technicians’ prevention and control, patient management, disinfection, and medical waste disposal than the control group (p < 0.05). However, there was no statistically significant difference in hand hygiene assessment between the two groups. Based on the self-made questionnaire star-based survey, the online training group was more informed than the control group on the theoretical knowledge of the new coronavirus pneumonia.
Conclusion

Online training can effectively and safely improve the awareness regarding the infection-related knowledge and compliance of preventive measures. Thus, it should be implemented in hospitals to minimize the risk of cross-transmission among people.
Translation and Cross-Cultural Adaptation of the Questionnaire of Sleep Health for Using in Chinese Older
Authors: tang he , zhang min , liu yujin
Published: July 2020

Objective: to make the translation, cross-cultural adaption and content and face validation of Questionnaire of sleep health for use in Chinese elder, as well as measuring psychometric properties of the questionnaire. Methods: A methodological study carried out in six steps: translation of the instrument, consensus of the translations, back-translation, analysis by an expert committee, pre-testing and then evaluation of psychometric properties. Psychometric properties, including item analysis (the extreme group comparison and item-total correlations), content validity (item-level content validity index (I-CVI) and scale-level content validity index (S-CVI)), construct validity confirmatory factor analysis (CFA) and internal consistency (Cronbach’s α and test–retest reliability) were measured.Results: The instrument was translated, transculturally adapted and its final version consisted of 12 items. The Q-USM has excellent internal consistency (Cronbach’s α=0.76). The test–retest reliability coefficient was 0.97.The I-CVI ranged from 0.80 to 1.00, and the S-CVI was 0.98. CFA showed that the three-factor model explained 56.54% of the total variance, with a good model fit (likelihood ratio χ2/df=3.75, incremental fit index=0.86, comparative fit index=0.86, goodness-of-fit index=0.89, adjusted goodness-of-fit index=0.84, standardized root mean square error of approximation=0.09 and root mean square residual=0.02).Conclusion: The Q-USM was translated and adapted to Chinese elder, and the psychometric properties of the Chinese version of the questionnaire presented satisfactory. It’s providing assessment instruments for community elderly health. As the questionnaire is applied for the first time in China, it needs to be continuously improved.
Immediate postpartum haemorrhage at the Libreville University Hospital Centre: Epidemiological profile of women
Authors: WOROMOGO SYLVAIN HONORE , Ambounda Nathalie Ledaga , Yagata-Moussa Felicite-Emma , Ossouka Liela Agnes Okoyi , Tekem Vicky Noel Simo , Ango Eliane Okira , Kouanang Alain Jepang
Published: July 2020

Background

In Gabon, the frequency of maternal deaths directly related to Immediate PostPartum Haemorrhage (IPPH) is 15 to 25%, despite the different means that World Health Organization (WHO) has made available to the providers of the Emergency Obstetrical and Neonatal Care (EmONC). The objective of this study was to determine the prevalence and epidemiological characteristics of IPPH in order to improve its management and reduce the rate of maternal deaths.
Methods

An analytical retrospective study involved 42,728 records, whose data were collected using a chart collection form on the basis of information contained in partograms and other patient records. The description of the sample is made using numbers and proportions. The relationship between the etiologies of IPPH and certain characteristics of the women was established using the ORs with their 95% confidence interval. The difference was significant if p < 0.05.
Results

The prevalence of IPPH was 1.6%. The 20–39 age group was the most represented. Multiparous women accounted for 67.2%. Delivery hemorrhages accounted for 65.5% of IPPH. The main factors associated with delivery hemorrhages were multiparity (p < 0.001), preterm and postterm (p < 0.001), and child weight > 4,000 g (p < 0.001). Those associated with genital track injuries were young maternal age, multiparity (p < 0.001).
Conclusions

The prevalence of IPPH was 1.6%. The most common etiology was hemorrhage from delivery. Multiparity remains the most common risk factor and the young age of the patients. It is important to improve management through better assessment of blood loss in the immediate postpartum as well as capacity building of health providers on EmONC.
Human-Pathogenic Isolations in Stagnant Water During Peruvian El Niño-Costero Phenomenon
Authors: Moya-Sala Jeel Jr , Contreras-Pulache Hans
Published: July 2020

Objective: To evaluate the microbiological quality of stagnant waters in Lambayeque region, Peru during the lockdown caused by El Niño-costero phenomenon. Results: We conducted a descriptive study in four Lambayeque’s districts: (Chiclayo’s downtown, Mocupe, San José, and Pimentel). Two simultaneous samples were taken from each evaluation districts and were transported to the Hospital San Bartolome in Lima Peru for their entire microbiological analysis. We isolate of human-pathogenic microorganisms (Trichuris trichiura, Entamoeba histolytica, Staphylococcus aureus, and Salmonella typhi) that showed patterns of r-esistance to conventional first-line antimicrobials (penicillin, nalidixic acid, nitrofurantoin, and chloramphenicol). Likewise, we showed evidence of microorganisms related to the sampling site (district) and with the degree of affectation by the phenomenon (p<0.05). Our results suggests that the stagnant waters of four districts of Lambayeque presented Human-pathogenic parasites and bacteria of high-medical importance by the sudden changes in the climate through El Niño-costero phenomenon
The influence of comorbidity on the severity of COVID-19 disease: systematic review and analysis
Authors: Zaki Nazar , Mohamed Elfadil Abdalla , Ibrahim Sahar , Khan Gulfaraz
Published: July 2020

Background: A novel form of coronavirus disease (SARS-CoV-2) has spread rapidly across the world. This disease, originating in Wuhan, China, has become a global pandemic. What risk factors influence the severity of the disease is of considerable importance.Aim: This research is intended to offer a systematic review/meta-analysis for assessing how common clinical conditions and comorbidities correlate with COVID-19.Methodology: Two independent researchers undertook searches using Europe PMC, Google Scholar, and PubMed. In addition, a search engine was created for screening another 59,000 articles in COVID-19 Open Research Dataset (CORD-19). Screening was undertaken for any article related to comorbidity and their influence on the progress of the disease. Random-effects modeling was used to pool 95% confidence intervals (CIs) and odds ratios (ORs). The significance of all comorbidities and clinical conditions in relation to the severity of the disease were evaluated by employing feature extraction methods and machine-learning. Publication bias was assessed by employing funnel plots, and heterogeneity was tested in relation to I2.Results: The meta-analysis incorporated 12 studies covering 4101 confirmed COVID-19 patients from Chinese hospitals. The findings demonstrate that the most common comorbidities with the disease were hypertension (22.07%, OR 2.43 [95% CI: 1.71-3.45], p <0.0001), diabetes (11.34%, OR 2.27, [95% CI: 1.46-3.53], p = 0.0003), cardiovascular disease (10.76%, OR 2.89 [95% CI: 1.90-4.40], p <0.0001), and COPD (2.53%, OR 3.24 [95% CI: 1.99-4.45], p< 0.0006). No significant associations were found for disease severity with the comorbidities of kidney disease, liver disease, or cancer.The most frequently exhibited clinical symptoms were fever (74.52%, OR 1.37, 95% CI: 1.01-1.86, p = 0.04), cough (62.15%, OR 1.25, 95% CI: 0.97-1.60, p = 0.0823), myalgia/fatigue (38.77%, OR 1.31, 95% CI: 1.11-1.55, p = 0.0018), dyspnea (33.9%, OR 3.61, 95% CI: 2.57-5.06, p = <0.0001), and respiratory failure/ARDS (20.6%, OR 11.46, 95% CI: 3.24-40.56, p = 0.0002). Meta-analysis also revealed that neither the duration of the incubation period nor current smoking status associated with disease severity.Conclusion: Existing comorbidities, including COPD, cardiovascular disease, coronary heart disease, diabetes, and hypertension represent a risk of increasing the severity of the disease in COVID-19 patients.
A Two-Stage Purkinje Network for More Accurate ECG Representations
Authors: Shalaby Noha , Aguib Heba , Badran Mohamed , Elkhodary Khalil
Published: July 2020

In this manuscript we propose a method to generate Purkinje networks that are anatomically and physiologically plausible, for use with in-silico modeling. Purkinje networks play a fundamental role in shaping cardiac electrical activation patterns and their corresponding clinical electrocardiograms (ECGs). Despite a known variability in ventricular activation sequences, certain sites of early activation within the left and right ventricles have been identified in the literature for normal electrical excitation patterns. Nevertheless, in-vivo imaging of Purkinje networks cannot at present yield detailed information on their structure, so there is a genuine need for in-silico models that can construct Purkinje networks that are both anatomically and physiologically plausible, in particular networks that can exhibit correctly situated early activation sites in the ventricles. Of special interest to this manuscript is the method of representation of Purkinje networks by line-like electrical elements that are generated by means of a fractal-tree algorithm (1–3) to overlay the irregular endocardial surfaces. A known drawback to a direct implementation of this approach in complex geometries relates to its incorrect modeling of clinically observed ECGs and electrical activation sequences for a human heart (4). Our aim was thus to correct this deficiency by generating Purkinje networks that leverage a pre-knowledge of the location of early activation sites. At every such site we first generate a Purkinje sub-network. These sub-networks are linked together and to the bundle of His, setting up our first stage of the Purkinje network. Subsequently, we spawn a second stage to the Purkinje network from one or more tips of any given sub-network, to cover the full endocardial surface with Purkinje elements. Our resulting activation sequences and ECGs compare favorably to those of a population of 39 healthy male individuals (the PTB diagnostic database), and our corresponding mechanical markers of cardiac function also match well with the literature.
Mesonephric Adenocarcinoma Arising From The Uterine Corpus：Case Reports and Literature Review
Authors: HU Qian , Xu Qin , Deng Yan Chun , Guo Tao , Wu Li Xiu
Published: July 2020

Background Mesonephric adenocarcinoma (MNAC) is a rare carcinoma which arises from the mesonephric remnant of the gynecologic tract. It mainly occurs in the uterine cervix, barely locates in the uterine corpus, ovarian and vagina. To date, only a few cases of MNAC arising from of the uterine body (UB-MNAC) have been reported, and the clinicopathologic and molecular characteristics of UB-MNAC remain limited. A recent report suggested that series of UB-MNAC should be defined as Mesonephric-like adenocarcinoma carcinomas (MLAC), for they exhibited the classic morphologic features and immunophenotype of mesonephric carcinoma, but occurring outside of the cervix and without convincing mesonephric remnants. Thus, the histogenesis of UB-MNAC is not yet clear, they may originate in Müllerian tissue and exhibits the mesonephric differentiation phenotype, or arise from the mesonephric remnants in the uterine wall.Case presentation To better understand the histogenesis of UB-MNAC, we presented three UB-MNAC cases from west china second university hospital, which exhibited typical morphologic, histologic as well as the immunohistochemical characteristics of MNAC. Notably, among the three cases, two cases arising from the myometrium layer of the uterine corpus found mesonephric remnants around the tumor. By reviewing the published UB-MNAC and UB-MLAC, we found that to our knowledge ,it is the first time finding mesonephric remnants around the MNAC cells in the reported literature, except one case that found mesonephric remnants in the cervix, and the tumors of the three cases were all arising from the myometrium layer, without endometrium involved. Then we compared the clinical characteristics of the UB-MNAC cases arising from the myometrium and endometrium, and the results showed that the two subgroups had most in common in the clinical characteristics except the myometrium subgroup had a higher elevated CA125 level, and this result was in consistent with the Kaplan-Meier survival analysis, which indicated that the myometrium subgroup had a poorer prognosis than the endometrium group. But this need more data and further study such as the molecular analysis.Conclusion Though the pathogenesis of MLAC or MNAC of the uterine corpus is still under debate, according to our cases and the published literatures, We hypothesize two different pathways involved: the MNAC arising from the myometrium not affecting the endometrium may directly develop from the mesonephric remnant, the one occurred in the endometrium may not real mesonephric adenocarcinoma, but more likely arising from mesonephric transformation of Müllerian adenocarcinoma, and is better referred as MLAC. Besides, the two kinds of adenocarcinomas may have different clinical prognosis, while the MNAC arising from the myometrium may have a poorer prognosis than the MLAC originating from the endometrium, although they have identical morphologic and histologic characteristics.
Epidemiological Features and Hotspot of COVID-19 in Isfahan Province of Iran: Results of A Cohort Study
Authors: Janani Majid , Beheshti-Nia Fereshte , Ahmadi Hamzeh , Khazeni Atefeh , Yadegarafar Ghasem
Published: July 2020

Background and Aim: The aim of this study was to description of the epidemiological features and hotspot of COVID-19 in Isfahan province of Iran.Method: In this descriptive, retrospective cohort, multicenter study, all patients admitted to one of the hospitals or health networks of Isfahan province from 3rd February to 13th June 2020 due to RT-PCR (Reverse transcription-polymerase chain reaction) test were enrolled to study. Trained staff followed up participants for two weeks by a Telephone number, and the outcome was recorded.Result: Up to 13 June, 41,498 patients recruited and their data were analyzed; the incidence of COVID-19 was 27.5% (95% CI: 27.1, 28.2). Among the participants with the positive test, 93.2% of them, treated by outpatient basis or discharged, 2.1% were hospitalized, and the case fatality rate (CFR) was 4.8%. Khansar and Aradestan was the hotspot of COVID-19 and had the highest incidence among cities of Isfahan province. Najafabad, Khomeinishahr, and Shahinshahr&Meymeh had the highest imported cases of COVID-19 to the capital of Isfahan province, Isfahan city. Also, Charmahal & Bakhtiari, Khuzestan, and Fars provinces had the highest number of imported cases from other provinces to Isfahan city. We found that 77.3% of intra-province imported cases and about 83% of inter-province cases were imported after reducing lockdown.conclusion:The incidence and fatality of COVID-19 in Isfahan province is alarming. Inter-city and inter-provincial unnecessary travels have a high impact on the transmission and spread of the COVID-19. Applying more restrictions will prevent this from happening. It is advised to restrict the inter cities travels again by policy makers for the benefit of public health.
Reconsideration of the Source Model for the 1662 Hyuga-nada Earthquake
Authors: Yamashita Yusuke , Ioki Kei , Kase Yoshihiro
Published: July 2020

The 1662 Hyuga-nada Earthquake is one of the largest earthquakes to have occurred in the Hyuga-nada region, Southwest Japan, rupturing the western part of the Nankai Trough subduction zone. Strong ground motion and a large tsunami with an estimated height of at least 4–5 m were reported along the coast of Miyazaki Prefecture, Kyushu Island, with extensive damage reported across this region. Therefore, developing a more complete picture of the 1662 Hyuga-nada Earthquake will improve our understanding of tsunami risk along the Pacific coast of Southwest Japan. Here we use the most recent geophysical data from the region to propose a novel source model for the 1662 Hyuga-nada Earthquake that incorporates our current understanding of the interactions between slow earthquakes and great earthquakes. The source area in our proposed model extends from the focal region of recurrent M7-class interplate earthquakes to the region of slow earthquakes that occur at relatively shallow depths along the plate boundary. Tsunami simulations indicate that the predicted coastal tsunami heights are broadly compatible with previously reported tsunami heights. This new model suggests that the 1662 Hyuga-nada Earthquake was probably a M8-class earthquake, and that previous magnitude determinations may have underestimated the strength of this historic earthquake. However, the model uncertainty remains large, and the calculated tsunami heights for the southern coast of Miyazaki Prefecture are very high. We suggest that future verification, including an analysis of tsunami-related deposits along the coast, will be important to more accurately determine the source area of the 1662 Hyuga-nada Earthquake.
Metaproteomics reveals potential signatures of disease-specific alterations in the gut microbial proteolytic events in inflammatory bowel disease
Authors: Yan Zhixiang , Xiao Fei , He Huanhuan , Li Dan , Cong Li , He Feixiang , Lin Lu , Wu Yanyan , Yan Ru , Li Xiaofeng , Shan Hong
Published: July 2020

Background:

Proteolysis regulation allows gut microbes to respond rapidly to dynamic intestinal environments by fast degradation of misfolded proteins and activation of regulatory proteins. However, alterations of gut microbial proteolytic signatures under complex disease status such as inflammatory bowel disease (IBD, including Crohn’s disease (CD) and ulcerative colitis (UC)) have not been investigated. Here, we explored the microbial proteolysis landscape using two public datasets containing 623 metaproteomes from 447 fecal and 176 mucosal luminal interface (MLI) samples from IBD patients and healthy individuals using a semi-tryptic peptide centric mining approach.
Results:

Fecal metaproteome revealed a global alteration of gut microbial proteolysis signatures in IBD, while MLI metaproteome demonstrated remarkable disease-specific and location-specific alterations at taxonomic, functional, and cleavage site motif levels. The functional alterations in IBD mainly involved microbial carbohydrate transport and metabolism, oxidative stress, cell motility, protein synthesis and maturation. Altered microbial proteolysis signatures of CD and UC mainly occurred in terminal ileum and descending colon, respectively. Microbial proteolysis patterns exhibited low correlations with β-diversity and moderate correlations with microbial protease transcriptome, respectively. Human protease inhibitors and immunoglobulins were mainly negatively associated with microbial proteolysis patterns, suggesting the inhibitory effects of these host factors on gut microbial proteolysis events.
Conclusions:

Our findings highlight the complex and diverse proteolytic alterations of gut microbiome in IBD, providing a unique layer of information beyond taxonomic and proteomic abundance.
Faith-Based Lifestyle Intervention Program Reduces Metabolic Syndrome in a High-risk Population
Authors: Davis Ronda Rose , Hwang Hyo-Jeong , Reid Easton A. , Chung Joo Youn , Scott Andrea Leah , Powell-Stoddart Helen , Jung Tae-Hwan , Han Kyoung-Sik
Published: July 2020

Introduction: The aim of this study was to investigate the effects of a two-week lifestyle intervention on risk factors contributing to metabolic syndrome that incorporated a natural environment with spiritual motivation, plant-based nutrition, personalized physical activity, and health education.Methods: The demographic population included forty-two middle-aged and aged participants of African-American or Afro-Caribbean/Other Afro-descent, considered “high-risk” according to clinical cardiometabolic risk indicators.Results: Based on the stratified analysis, 59.5% and 40.5% were of African-American and Afro-Caribbean/Other Afro-descent respectively, with a mean age of 59.23 ± 11.24 years. The paired t-test indicated that plasma concentrations of glucose (P = 0.043) and triglyceride (P = 0.002) post-intervention reduced compared to pre-intervention baselines. In female participants, blood HDL cholesterol concentrations significantly (P < 0.0001) increased compared to pre-intervention values.Conclusion: This research suggests that the Fit 4 You Retreat lifestyle intervention program significantly reduced cardiometabolic vulnerability in this high-risk middle-aged and aged population.
Psychometric properties of Nurses Professional Values Scale-Revised: An Iranian version
Authors: Hosseini Fahimeh Alsadat , zarshenas ladan , Parvan Kobra , Bagherian Samaneh , Thomson Brian
Published: July 2020

Background

Professional values are the basis of development of professional identity and commitment. Evaluation of professional values provides critical information regarding effective strategies for their integration in professional performance and clinical learning. The present study aimed to determine the psychometric properties of Nurses Professional Values Scale-Revised (NPVS-R) in Iranian population.
Methods

This methodological study was conducted on 439 students in the last semester of nursing selected from Iran’s universities using stratified single-stage cluster sampling. After back translation, its face, content, and construct validity were assessed. Its reliability was also evaluated by determining Cronbach’s alpha using internal consistency method. All analyses were performed using the SPSS statistical software, version 19.
Results

Considering face validity, all items’ impact scores were above 1.5. Regarding content validity, CVR and CVI of all components were > 0.6 and = 1, respectively. After exploratory factor analysis, the number of items was reduced to 25 and five factors explained 52.26% of the total variance. Moreover, the reliability coefficient was 0.53–0.83 for the factors and 0.91 for the whole scale.
Conclusions

The Persian version of NPVS-R had acceptable validity and reliability in Iranian context. Yet, further studies have to be conducted on this instrument with different cultural backgrounds.
Association of NT-proBNP and Subsequent Major Adverse Cardiovascular and Cerebral Events in Patients with Successful PCI for ACS and Normal LVEF
Authors: Wang Jia-Li , Zhao Shu-Mei , Chen Hui , Guo Chun-Yan , Zhao Xue-Qiao , Li Hong-Wei
Published: July 2020

Background: Does N-Terminal pro-brain natriuretic peptide (NT-proBNP) predict subsequent major adverse cardiovascular and cerebral event (MACCE) in patients received successful percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) and had normal left ventricular ejection fraction (LVEF)? Methods: 3986 ACS patients were divided into 4 groups based on the quartile (Q) values of peak NT-proBNP measured during hospitalization. All patients were followed for MACCE, a composite of all-cause death, non-fatal myocardial infarction (MI) or stroke, and heart failure requiring hospitalization (HFRH), during a median of 35 months. The incidence of MACCE was compared among Q1-Q4. Receiver operation characteristic curves (ROC) were generated to compare the area under the curve (AUC) for MACCE, cardiovascular (CV) death and HFRH by adding NT-proBNP to the TIMI (thrombolysis in myocardial infarction) risk score.Results: The incidences of MACCE (5.6%, 9.1%, 13.0%, 20.1%, P <0.001), all-cause death (1.0%, 2.5%, 4.1%, 8.4%, P <0.001), non-fatal MI (2.0%,3.4%,4.8%,6.2%, P <0.001) and HFRH (1.5%, 2.3%, 4.1%, 5.9%, P <0.001) were significantly increased from Q1 to Q4, but, not stroke (1.4%, 1.4%, 1.3%, 2.1%, P =0.438). Each median level (337pg/ml) increase in NT-proBNP was significantly and independently associated with increased risk of MACCE (HR 1.02, 95%CI, 1.01-1.03; P <0.001). Compared with TIMI (thrombolysis in myocardial infarction) risk score alone, TIMI+NT-proBNP showed improved AUCs: CV death (0.76 vs. 0.72, P =0.0008), and HFRH (0.68 vs. 0.66, P =0.0017), MACCE (0.70 vs. 0.69, P =0.0012), respectively. Conclusion: NT-proBNP was significantly and independently associated with increased risk of subsequent MACCE in 3 years in ACS patients who received successful PCI and had normal LVEF, and improved the prognosis of major adverse events in addition to the TIMI risk score.
Tumor-To-tumor Metastasis: Prostatic Cancer Metastasizing to Malignant Solitary Fibrous Tumor of The Lung
Authors: Lian Yuane , Yang Yinghong , Feng Changyin , Kang Deyong
Published: July 2020

Background: Tumor-to-tumor metastasis is an extremely rare but interesting phenomenon. Prostatic cancer metastasizing to malignant solitary fibrous tumor (SFT) of the lung has not been previously reported.Case Presentation: In this report, we describe the case of a 60-year-old man presenting a large solitary neoplasm in the left lung on computed tomography. Pathology after left lung wedge resection indicated two different cancerous cell components: SFT cells with malignant potential and prostatic cancer cells. The heterogeneous cells of prostatic origin were confirmed by using evidence from fine needle aspiration and pathology after radical prostatectomy.Conclusions: We report the first tumor-to-tumor metastasis of prostatic cancer to lung malignant SFT.
Comprehensive Analysis of Differentially Expressed Long Non-Coding RNA-mRNA in The Adenoma–Carcinoma Sequence of DNA Mismatch Repair Proficient Colon Cancer
Authors: Li Wenkun , Li Qian , Ge Jiang , Wang Yun , Li Nanshan , Lao Yueqiong , Wang Yadan , Liu Kuiliang , Guo Chunmei , Lin Wu , Jiang Guojun , Wei Nan , Wang Canghai , Liu Hong , Wu Jing
Published: July 2020

Background DNA mismatch repair proficient colon cancer (pMMR CC) is the most common subtype of sporadic CC. However, the role of long non-coding RNAs (lncRNAs) in pMMR CC carcinogenesis has not been fully elucidated. Methods In the present study, we conducted transcriptomic analysis of lncRNAs-mRNAs in five low-grade intraepithelial neoplasia (LGIN), five high-grade intraepithelial neoplasia (HGIN), four pMMR CC, and five normal control (NC) tissues. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment pathway, and Co-Expression Network analyses were performed to elucidate the functions of lncRNAs and mRNAs as well as their interactions. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to validate five dysregulated lncRNAs in a large set of colon tissues. Receiver-operating characteristic (ROC) curves were employed to evaluate the performance of the candidate lncRNAs. Results A set of 5783 differentially expressed lncRNAs and 4483 differentially expressed mRNAs were detected among the LGIN, HGIN, pMMR CC, and NC samples. These differentially expressed lncRNAs and mRNAs were assigned to 275 significant GO terms and 179 significant KEGG enriched pathways. qRT-PCR confirmed that the expression of five selected lncRNAs (ENST00000521815, ENST00000603052, ENST00000609220, NR_026543, and ENST00000545920) were consistent with the microarray data. ROC analysis showed that four lncRNAs (ENST00000521815, ENST00000603052, ENST00000609220, and NR_026543) had larger area under the ROC curve (AUC) values than serum carcinoembryonic antigens, thereby distinguishing NC from pMMR CC. Conclusions Several lncRNAs play various roles in the adenoma–carcinoma sequence and may serve as potential biomarkers for the early diagnosis of pMMR CC.
Visual Outcome, Microbiological Profile and Antibiotic Sensitivity of Infectious Keratitis in a Tertiary Referral Center
Authors: Stanfield Kristina Moore , Huang Bo , Matherne Blake , Adah Osasu , McClung Daniel , Le Thuy , Ladner Morgan
Published: July 2020

Purpose:Treatment of infectious keratitis is chosen by identification of infection source with associated antibiotic susceptibilities. Because culturing corneas may take days to weeks to result, the mainstay of treatment is empirical therapy with broad-spectrum antimicrobials that are started before culture results return. We aim to record the microbiological profiles with associated antibiotic susceptibility patterns isolated from corneal cultures in patients with infectious keratitis, as well as visual outcomes over a 5-year period.Methods:A retrospective analysis of medical records of patients who presented to UMMC from 1/1/2014 to 12/31/2018 with keratitis or corneal ulcer were included in this study based off diagnosis codes.Results:Of 563 corneal infections analyzed, 202 (35.9%) had positive cultures. The most frequently isolated organism was Coagulative negative Staphylococcus/Staphylococcus epidermidis, followed by Pseudomonas aeruginosa, and Staphylococcus aureus. Pseudomonas aeruginosa was isolated in 37.2% contact lens wearers. We found that 93.3% of gram-positive cultured bacteria were susceptible to vancomycin with no resistance, and 81.8% of gram-negative bacteria were highly susceptible to tobramycin with no resistance. Regardless of treatment, 19.8% of patients needed some type of additional procedure, with the most common procedures being corneal transplant & evisceration. Conclusion:CNS, Pseudomonas aeruginosa, and Staphylococcus aureus were the most common microbes causing infectious keratitis. Pseudomonas aeruginosa remains the most commonly identified organism in contact lens wears. The empirical treatment of vancomycin and tobramycin used at our institution remains an excellent treatment for these microbes.
The Serum Level of Vitamin D and Hypocalcemia in Thyroidectomy Candidate Patients Referred to a Tertiary Care Hospital in the North of Iran
Authors: Hemmati Hossein , Poursafar Mehdi , Farzin Mohaya , Motamed Behrang , Samidoost Pirooz , Rafiei Elahe , Bahush Soudabeh
Published: July 2020

Objective: Vitamin D plays a crucial role in calcium metabolism through the Parathyroid hormone (PTH) dependent process. The deficiency of this important nutrient may be associated with hypocalcemia after thyroidectomy. To evaluate the role of vitamin D in predicting hypocalcemia following total thyroidectomy.Results: sixty-two patients who underwent total thyroidectomy for benign or malignant thyroid disease were included in this prospective study. Preoperative vitamin D serum levels and PTH levels were determined. The results of our study showed In both groups with and without vitamin D deficiency, calcium levels decreased significantly (P = 0.01). In our study, it was found that there was no significant relationship between postoperative hypocalcemia and vitamin D deficiency. (P = 0.441). After reviewing the data and according to Spearman correlation statistical test, no significant relationship was observed between serum PTH and calcium after thyroidectomy (P = 0.340).Vitamin D deficiency is a risk factor of hypocalcemia after total thyroidectomy for benign goiter. Although post thyroidectomy hypocalcemia is multifactorial, vitamin D deficiency, particularly severe form, is significantly associated with the development of biochemical and clinical hypocalcemia vitamin D supplementation can prevent this unwanted complication in such patients.