bluuebunny/crossref_metadata_2025 huggingface dataset:
Ownership Structure, Size, and Banking System Fragility in India: An Application of Survival Analysis
Authors: Kaur Navneet , Shrivastav Santosh , Oberoi Sarbjit Singh
Published: March 2022

The Reserve Bank of India has put 11 public sector banks under prompt corrective action and is planning to put three more where public sector banks constitute 68.9% of the total asset of the Indian banking industry based on 2018 figures; this raises a genuine concern for the financial health of the Indian banking sector as a whole. Under these considerations, this study is conducted to estimate the survival of banks based on ownership and size and uses the Cox proportional hazards model. This study has not found any significant difference in the failure risk of both public and private sector banks based on ownership. However, the study found a significant difference in the failure risk of banks based on size. The smaller banks are indeed at a higher risk of failure than larger banks. The findings of this study can be used to create an early warning system for smaller banks in India.
Does Perceived Corruption Converge? International Evidence
Authors: Lafuente Juan Ángel , Marco Amparo , Monfort Mercedes , Ordóñez Javier
Published: March 2022

This article analyses the evolution over time of perceived corruption for a large set of countries worldwide. To proxy corruption, we use the recently proposed Bayesian Corruption Index (Standaert, S. (2015). Divining the level of corruption: A bayesian state space approach, Journal of Comparative Economics, 43(3), 782–803). We employ the test developed by (Phillips, P., & Sul, D. (2007). Transition modeling and econometric convergence tests. Econometrica, 75, 1771–1855) that enables the endogenous determination of convergence clubs for countries over time. Having divided countries into convergence clubs, we explore whether each club differs from the others in terms of their competitiveness ranking. In particular, drawing on the 2019 Global Competitiveness Report, we focus not only on the global competitiveness score, but also on the first and the fifth pillars of competitiveness: institutions and health, respectively. Mean and median scores for clubs confirm the general rule that low perceived corruption levels tend to be associated with high-income countries with established democracies, high-quality healthcare systems, and relatively low-income inequality. However, countries such as Spain and Italy, which are innovation-driven economies with excellent scores in the health pillar, are in the worst club for perceived corruption, suggesting there are additional idiosyncratic aspects that could drive perceived corruption levels.
Improved photocatalytic degradation of malachite green with a novel composite β-bihydroxycobalt phthalocyanine/Cu-BTC
Authors: Yin Yanbing , Yang Hang , Xin Zhaosong , Xu Guopeng , Liu Yang , Dong Guohua , Ma Jie
Published: March 2022

In this work, a novel MOF (metal organic framework) based composite of β-BCoPc/Cu-BTC is fabricated by immobilizing β-aryloxy phthalocyanine cobalt (β-BCoPc) on Cu-BTC (benzenetricarboxylic acid-Cu) via a facile impregnation approach. After a systematic characterization via X-ray diffraction, X-ray photoelectron spectroscopy, infrared spectroscopy, scanning electron microscopy, transmission electron microscopy and N2 adsorption–desorption isotherms, the above-synthesized catalyst is for the first time applied to photocatalytically decompose refractory malachite green (MG) dye pollutant under UV light irradiation. In comparison with that of the β-BCoPc or Cu-BTC monomers, the synthesized β-BCoPc/Cu-BTC composite shows a significantly enhanced photocatalytic degradation performance of MG with a best degradation efficiency up to 90.12 %, which can easily be attributed to the synergistic effect between the Cu-BTC and β-BCoPc effectively improving light utilization efficiency, accelerating charge transportation and reducing charge recombination due to the desirable properties such as the conjugacy of the MOFs skeleton, the positive catalytic activity of central ion and large specific surface area, etc. In conclusion, the present work provides an effective and novel strategy via preparing MOF-based composite catalyst to realize the photocatalytic degradation of MG.
Decomposition of the total effect for two mediators: A natural mediated interaction effect framework
Authors: Gao Xin , Li Li , Luo Li
Published: March 2022

Mediation analysis has been used in many disciplines to explain the mechanism or process that underlies an observed relationship between an exposure variable and an outcome variable via the inclusion of mediators. Decompositions of the total effect (TE) of an exposure variable into effects characterizing mediation pathways and interactions have gained an increasing amount of interest in the last decade. In this work, we develop decompositions for scenarios where two mediators are causally sequential or non-sequential. Current developments in this area have primarily focused on either decompositions without interaction components or with interactions but assuming no causally sequential order between the mediators. We propose a new concept called natural mediated interaction (MI) effect that captures the two-way and three-way interactions for both scenarios and extends the two-way MIs in the literature. We develop a unified approach for decomposing the TE into the effects that are due to mediation only, interaction only, both mediation and interaction, neither mediation nor interaction within the counterfactual framework. Finally, we compare our proposed decomposition to an existing method in a non-sequential two-mediator scenario using simulated data, and illustrate the proposed decomposition for a sequential two-mediator scenario using a real data analysis.
Prevalence of nephropathy in Indian children and youth with type 1 diabetes mellitus
Authors: Karguppikar Madhura , Oza Chirantap , Shah Nikhil , Khadilkar Vaman , Gondhalekar Ketan , Khadilkar Anuradha
Published: March 2022

Objectives

Children with type 1 diabetes (T1D) having diabetic nephropathy (DN) are at increased risk of developing end stage renal disease. The present study aimed to determine the prevalence of DN and its predictors in Indian children and youth with T1D.

Methods

This cross-sectional study included 319 children and youth (2.6–21 years) with T1D having disease duration of at least 2 years. Demographic data and laboratory findings were obtained using standard questionnaires and protocols. Diagnosis of diabetic nephropathy was based on albuminuria on two occasions within a period of 3 months.

Results

The prevalence of DN in our study subjects was 13.4%. 7.5% subjects were known cases of diabetic nephropathy on treatment with enalapril. Hypertension was found in 14.3% subjects with DN in contrast to 4.1% without DN (p<0.05). Duration of diabetes and estimated glucose disposal rate were the important predictors of DN. Interestingly, of the 43 children with DN, 11.3% (n=8) were under 10 years age.

Conclusions

We found a high prevalence of DN in children and youth with T1D including in children under the age of 10 years. Early screening and timely intervention are required to retard the disease progression and avoid end stage renal disease.
Thermal hydraulic analysis and design of the WWR-M2 nuclear research reactor – power upgrading
Authors: Bsebsu F. M. , Bede G.
Published: March 2022

This paper presents the outline of the core thermal hydraulic design and analysis (Operational Safety Analysis) of the Budapest nuclear research reactor (WWR-M2 type), which is a tank-type, light water-cooled nuclear research reactor with 36% enriched uranium coaxial annuli fuel. The research reactor is currently upgraded to 10 MWth of thermal power, while the cooling capacity of the reactor was designed and constructed for 20 MWth. This reserve in the cooling capacity serves redundancy today but can be used for future upgrading too. The core thermal hydraulic design was, therefore, done for the normal operation conditions so that fuel elements have enough safety margins both against nucleate boiling anywhere in the reactor core. Thermal hydraulic performance was studied. It is shown that the 36% enriched UAlx-Al fuel elements in WWR-SM fuel coolant channel do not allow to force up the reactor power to 20 MWth. The study was carried out for an equilibrium core, with compact load (223 fuel assemblies) under normal operation conditions only (steady state condition).
Berechnungsverfahren für Temperaturen im Brandnahbereich
Authors: Blume G. , Siegfried W.
Published: March 2022

Für die ingenieurgemäße Untersuchung brandschutztechnischer Fragestellungen, die im Rahmen von individuellen Brandschutzkonzepten vorgenommen werden, ist häufig die Kenntnis von Umgebungstemperaturen im Umfeld des Brandereignisses wesentlich. Dabei stehen Fragen nach dem Auslösezeitpunkt von Sprinklern, die Temperaturbeaufschlagung von Bauteilen und das Erreichen kritischer Temperaturen Für Menschen oder Baustoffe im Vordergrund. Vielfach wird diese Berechnung mit Zonenmodellen oder überschlägig mit Plume-Ansätzen vorgenommen. Bei dieser Vorgehensweise werden häufig lokale Effekte nicht beachtet oder in Fällen, bei denen sich während des Brandverlaufes eine heiße Rauchgasschicht bildet, zu geringe Plume-Temperaturen berechnet. Mit Hilfe von modifizierten Ansätzen, wie sie in diesem Bericht vorgestellt worden sind, besteht die Möglichkeit, realistischere Werte zu berechnen, da sie insbesondere eine Vermischung der im Plume aufsteigenden Verbrennungsgasen mit den heißen Rauchgasen einer ausgebildeten Rauchgasschicht mit endlicher Temperatur in die Betrachtung einbeziehen.
Ultrasensitive nanoscale optomechanical electrometer using photonic crystal cavities
Authors: Xia Ji , Qiao Qifeng , Sun Haoyang , Huang Yongjun , Chau Fook Siong , Zhou Guangya
Published: March 2022

High-precision detection of electric charge is critical for physical, chemical, and biological measurements. Nanophotonic optomechanical system confines the optical field at the nanoscale and enables a strong interaction between optical cavity and mechanical resonator. Its high optical quality factor cavity and strong optomechanical coupling are promising for precision sensing applications. Here an integrated optomechanical electrometer is proposed for the electric charge sensing using a zipper cavity with a suspended photonic crystal nanobeam (PCN) acting as a movable mechanical resonator. As the electrostatic force arising from the electric voltage to be measured interacts with the mechanical motion of the movable PCN and modulates its resonance through electrostatic stiffening effect, optomechanical coupling transduces the mechanical motion to the optical field with enhanced sensitivity. The resonance shift of the mechanical resonator can be monitored to detect the electric voltage with a sensitivity of 0.007 

Hz
/
m

V
2

$\mathrm{Hz}/\mathrm{m}{\mathrm{V}}^{2}$

. Moreover, the sensing performance can be further enhanced with the operation of the optomechanical electrometer in the self-sustained oscillation above threshold power. Owing to the narrow-linewidth of detector radio frequency (RF) spectrum with a large peak-to-noise floor ratio (up to 73.5 dB), the enhanced electrical sensitivity of 0.014 

Hz
/
m

V
2

$\mathrm{Hz}/\mathrm{m}{\mathrm{V}}^{2}$

is achieved with a high resolution of

1.37
 
m

V
2

H

z

−
1
/
2

$1.37\,\mathrm{m}{\mathrm{V}}^{2}\mathrm{H}{\mathrm{z}}^{-1/2}$

. A theoretical minimal detectable electrostatic charge is calculated as

1.33
×

10

−
2

 
eH

z

−
1
/
2

$1.33{\times}{10}^{-2}\,\mathrm{eH}{\mathrm{z}}^{-1/2}$

by converting the measured electric voltage versus RF shift to an approximatively linear relationship. This on-chip optomechanical electrometry scheme provides a powerful solution to the ultrasensitive determination of charged nanoparticles in biological and chemical applications.
Mechanisms driving self-organization phenomena in random plasmonic metasurfaces under multipulse femtosecond laser exposure: a multitime scale study
Authors: Eles Balint , Rouquette Paul , Siegel Jan , Amra Claude , Lumeau Julien , Moreau Antonin , Hubert Christophe , Zerrad Myriam , Destouches Nathalie
Published: March 2022

Laser-induced transformations of plasmonic metasurfaces pave the way for controlling their anisotropic optical response with a micrometric resolution over large surfaces. Understanding the transient state of matter is crucial to optimize laser processing and reach specific optical properties. This article proposes an experimental and numerical study to follow and explain the diverse irreversible transformations encountered by a random plasmonic metasurface submitted to multiple femtosecond laser pulses at a high repetition rate. A pump-probe spectroscopic imaging setup records pulse after pulse, and with a nanosecond time resolution, the polarized transmission spectra of the plasmonic metasurface, submitted to 50,000 ultrashort laser pulses at 75 kHz. The measurements reveal different regimes, occurring in different ranges of accumulated pulse numbers, where successive self-organized embedded periodic nanostructures with very different periods are observed by post-mortem electron microscopy characterizations. Analyses are carried out; thanks to laser-induced temperature rise simulations and calculations of the mode effective indices that can be guided in the structure. The overall study provides a detailed insight into successive mechanisms leading to shape transformation and self-organization in the system, their respective predominance as a function of the laser-induced temperature relative to the melting temperature of metallic nanoparticles and their kinetics. The article also demonstrates the dependence of the self-organized period on the guided-mode effective index, which approaches a resonance due to system transformation. Such anisotropic plasmonic metasurfaces have a great potential for security printing or data storage, and better understanding their formation opens the way to smart optimization of their properties.
Tutankhamun’s Polychrome Wooden Shawabtis: Preliminary Investigation for Pigments and Gilding Characterization and Indirect Dating of Previous Restorations by the Combined Use of Imaging and Spectroscopic Techniques
Authors: Abdrabou Ahmed , Abdallah Medhat , Sultan Gilan M. , Mostafa Mohamed , Bayoumi Hind , Magdy Ramy , Abd El Kader Mohamed A. , Hamza Nagmeldeen M. , Mamdouh Dina , Elsayed Hassan M. , Abbas Eltayeb , Kamal Hussein M.
Published: March 2022

To the best of our knowledge, such a detailed study on polychrome wooden shawabtis of King Tutankhamun (18th Dynasty in ancient Egypt) has not been reported in the literature, so the purpose of our study is to noninvasively identify the polychrome layers and previously applied materials for a number of wooden shawabtis that belong to King Tutankhamun through a protocol based on imaging techniques integrated with single-spot spectroscopic techniques. In the first step, imaging techniques (visible, ultraviolet induced visible luminescence, ultraviolet reflected, visible-induced infrared luminescence, infrared reflected, and infrared false color) and optical microscopy were applied to gather information and provide evidence on the distribution of original and previously applied materials on the polychrome surfaces. In the second step of our work, we analyzed the selected areas with single-spot analyses (handheld X-ray fluorescence spectroscopy and visible reflectance spectroscopy) and X-ray diffraction analysis. The materials of the previous restoration interventions were studied by Fourier transform infrared spectroscopy. The application of a protocol based on imaging techniques integrated with data obtained from single-spot spectroscopic techniques allowed the characterization of a remarkable number of polychrome layers and some previous restoration materials and mapping of their distribution on the original surface, which provides not only essential data for the follow-up treatment and conservation works but also offers important information for the study of polychrome wooden shawabtis of other periods in ancient Egypt.
Modifying the diet and gut microbiota to prevent and manage neurodegenerative diseases
Authors: Gates Ellen J. , Bernath Anna K. , Klegeris Andis
Published: March 2022

The global prevalence of Alzheimer’s disease and Parkinson’s disease is steadily increasing due to the aging population. The lack of effective drugs against these neurodegenerative disorders makes it imperative to identify new strategies for their prevention and treatment. Recent studies have revealed that harnessing the power of the gut microbiota through modification of diet may be a valuable approach for reducing the risk, modulating the symptoms, and ameliorating the pathophysiological aspects of neurodegenerative diseases. Consuming specific dietary components can alter the prevalence of bacterial communities within the gut to a healthy enterotype, which can influence the production of beneficial metabolites by microbiota. This article focuses on several dietary components, which have been demonstrated to affect the gut microbiota–brain axis and therefore could lead to attenuation of specific pathological processes in neurodegenerative diseases. Published evidence indicates that fermented foods, including kefir, and foods that are high in bioactive polyphenols and complex carbohydrates, such as grapes, pomegranates, and seaweed, may be effective at reducing neuroinflammation, oxidative stress, neurotransmitter dysfunction, and neuronal death associated with Alzheimer’s and Parkinson’s diseases. Even though experimental evidence supporting the protective properties of the above dietary components in these diseases is emerging, it is evident that further human clinical studies are required to conclusively establish the benefits of any suggested dietary interventions. The translational potential of such research is illustrated by the clinical success of the recently developed Alzheimer’s drug, GV-971, which is a seaweed derivative that works by modulating the gut microbiota–brain axis.
Steiner distance matrix of caterpillar graphs
Authors: Azimi Ali , Bapat Ravindra B. , Goel Shivani
Published: March 2022

In this article, we show that the rank of the 2-Steiner distance matrix of a caterpillar graph having

N

N

vertices and

p

p

pendant veritices is

2
N
−
p
−
1

2N-p-1

.
Funktionsprinzip und Anwendung der Kraftkompensationsmessmethode für miniaturisierte hydrogelbasierte Sensoren
Authors: Binder Simon , Gerlach Gerald
Published: March 2022

Chemische Sensoren, die ein Stimulus-responsives Hydrogel als Messaufnehmer nutzen, bieten viele Vorteile. Die Hydrogele sind kostengünstig, einfach in der Herstellung und für verschiedenste Messgrößen auslegbar. Sensoraufbauten, die den stimulusabhängigen Quelldruck in ein elektrisches Messsignal wandeln, sind gut miniaturisierbar und als Plattform für verschiedene Hydrogelarten nutzbar. Wesentliche Nachteile hydrogelbasierter Sensorprinzipien sind jedoch das Kriechen und die langen Einstellzeiten im Minuten- bis Stundenbereich, die durch langwierige Diffusionsprozesse und das viskoelastische Verhalten der Hydrogele bedingt sind. Die Kraftkompensation ist eine Messmethode diesen beiden Effekten erfolgreich entgegenzuwirken, indem der zeittreibende Volumenphasenübergang des Hydrogels unterdrückt wird. Der hierfür benötigte Aktor verhinderte in früheren Arbeiten jedoch eine Miniaturisierung der Sensoraufbauten. In dieser Arbeit ist daher eine andere Art der Kraftkompensation gezeigt, welche es erlaubt, die vielen Vorteile der Kraftkompensationsmethode auf einen Hydrogelsensor anzuwenden, aber gleichzeitig geringe Abmessungen des Sensoraufbaus zu gewährleisten. Dies gelingt, indem der quellunterdrückende Aktor direkt in den Hydrogel-Messwandler hineinverlegt wird. Auf diese Weise geschieht die Quelldruck-Kompensation im Hydrogel selbst. Zu diesem Zweck ist das Hydrogel als bisensitives Hydrogel ausgelegt. Im Ergebnis verkleinert und vereinfacht sich der Sensoraufbau durch den Wegfall aufwändiger Aktoraufbauten deutlich. Gleichzeitig wird dennoch eine hohe Einstellzeitverkürzung gegenüber der herkömmlichen unkompensierten Messmethode erreicht und die bisherigen Kompensationsansätze mit einer minimalen Einstellzeit von ca. 3 min übertroffen. Es zeigt sich überdies eine signifikante Reduktion unerwünschter Hystereseeigenschaften und die Möglichkeit zur Messbereichserweiterung. Die Messmethode ist am Beispiel eines piezoresistiven Hydrogelsensors gezeigt und prinzipiell auf andere hydrogelbasierte Sensorprinzipien zur Verbesserung der Sensoreigenschaften übertragbar.
Effect of G-type integral squeeze film damper on the dynamic characteristics in rotor system
Authors: Yan Wei , He Lidong , Zhu Gang , Jia Xingyun
Published: March 2022

To solve the problems of the nonlinear damping force in the traditional squeeze film damper (SFD), a novel structure of G-type integral squeeze film damper (GISFD) based on ISFD is proposed for the first time. The finite element model and test rig of the ball bearing-rotor system are established to explore the influence of GISFD and ISFD on the dynamic characteristics of the unbalanced rotor system. The results show that both GISFD and ISFD can change the critical speed of the rotor system, reduce the bending strain energy of the shaft, and reduce the bearing dynamic load of the rotor system. Through comparison, it is found that the effect of GISFD is more obvious. The experimental results show that, compared with the unbalanced rotor system without damper, the peak-peak value of amplitude in the rotor system with GISFD and ISFD at 3000 rpm is reduced by 25.53 and 15.81%. The amplitude in the disk at the first-order critical speed is effectively reduced, and the reduction range reach 52.01 and 35.44%, respectively. GISFD has a more significant effect of suppressing unbalanced vibration, and has superior vibration damping performance when compared with ISFD.
Syntheses, crystallographic characterization, and structural relations of Rb[SCN]
Authors: Shlyaykher Alena , Pippinger Thomas , Schleid Thomas , Reckeweg Olaf , Tambornino Frank
Published: March 2022

Colorless rubidium thiocyanate was synthesized by three different approaches. DCS-TGA measurements allowed for extraction of phase transition, melting, and decomposition temperatures. Single-crystal X-ray diffraction showed Rb[SCN] to crystallize in the low-temperature LT-K[SCN] crystal structure type (Pbcm, oP16). Above its phase-transition temperature (432.1 K) the title compound crystallizes with the high-temperature HT-K[SCN] crystal structure type (I4/mcm, tI28) with head-to-tail disordered thiocyanate anions. Both modifications are related to one another and to the LT/HT-Cs[SCN] structure types, and the relation has been studied in detail employing the Bärnighausen formalism. Phase purity and bulk phase transition were confirmed by temperature-dependent PXRD.
[RETRACTED] Calmwave CBD Gummies Reviews - Canada 2022 v1
Authors: not provided calmwavegummiesreviews
Published: March 2022

[RETRACTED]

Calmwave CBD Gummies Reviews - Canada 2022
[RETRACTED] Grow X Male Enhancement Reviews - Scam or Legit Pills 2022 v1
Authors: not provided growmalereviewspills
Published: March 2022

[RETRACTED]

Grow X Male Enhancement Reviews - Scam or Legit Pills 2022
[RETRACTED] Biovana Skin Serum Reviews - Does It Works? v1
Authors: not provided biovanaskinumreviews
Published: March 2022

[RETRACTED]

Biovana Skin Serum Reviews - Does It Works?
Expression of miR-302a, miR-302b, miR-302c, miR-302d, miR-367, miR-371, miR-372, miR-373, miR-10b, miR-21 and miR-93 in cells of different histotypes of testicular germ cell tumors
Authors: Knyazeva M. S. , Zagoruiko V. A. , Khokhlova A. V. , Nazarova I. V. , Shalaev A. V. , Sidina E. I. , Zabegina L. M. , Artemyeva A. S. , Nosov A. K. , Protsenko S. A. , Malek A. V.
Published: March 2022

Introduction. Testicular germ cell tumor is a relatively rare disease. Its high social significance is due to the fact that this pathology occurs in young patients. The standard schemes of polychemotherapy determine the potential possibility of effective treatment for most of the patients even with an advanced disease. Several circulating markers (alpha-fetoprotein, human chorionic gonadotropin and lactate dehydrogenase) are being used for therapy monitoring, but the low diagnostic specificity of these molecules determines the need to develop new approaches. Over the past years, circulating microRNA, for instance miR-371a-3p, appeared to be promising marker for testicular germ cell tumor monitoring. However, to develop and to implement in practice the microRNA-based diagnostic technologies, it’s necessarily to understand the features of the microRNA expression alterations specific for different histological types of testicular germ cell tumor.The study objective – to evaluate changes in the expression of several potential marker microRNA molecules (miR-302/ miR-367, miR-371/miR-373) in testicular germ cell tumor samples of various histological types.Materials and methods. Testicular germ cell tumor samples (n = 61), including seminomas, embryonic carcinomas, post-pubertal teratomas, yolk sac tumors, chorioncarcinomas, and corresponding normal tissue samples (n = 61) were included in the study. The analysis of selected miRNA expression was performed by reverse transcription and polymerase chain reaction.Results. We identified the changes in the expression profile of the miR-302/miR-367 cluster typical for semines, embryonic carcinomas, post-pubertal teratomas, yolk sac tumors and chorioncarcinomas, as well as changes in the expression profile of the miR-371/miR-373 cluster, universal for all histotypes except chorioncarcinomas. Inhibition of miR-10b and miR-145 expression in semines, embryonic carcinomas, and post-pubertal teratomas was demonstrated.Conclusion. Activation of miR-302b, miR-302d, miR-371a expression and inhibition of miR-10b, miR-145 expression in the tissue of the most common variants of testicular germ cell tumor is a characteristic feature of these tumors. The detected changes are significant and can lead to corresponding changes in the profile of circulating microRNAs.
3-Hydroxyquinazoline derivatives, analogues of erastin, induced ferroptosis in breast cancer cells
Authors: Borisova L. M. , Osipov V. N. , Golubeva I. S. , Kiseleva M. P. , Hochenkov D. A. , Vartanyan A. A.
Published: March 2022

Introduction. Early malignant tumor detection programs have significantly increased the survival rate of breast cancer patients but the results of drug therapy for this pathology are not always highly effective. Recently discovered iron-dependent cell death, ferroptosis, makes it a promising therapeutic target to reduce the recurrence rates.Objective – to study the induction of ferroptosis in breast cancer cells MCF-7 by quinazoline derivatives synthesized at the Research Institute of Experimental Diagnostics and Therapy of Tumors of the N.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia and to evaluate its antitumor activity on transplanted breast carcinoma Ca-755.Materials and methods. Derivatives of 3-hydroxyquinazoline were obtained by chemical synthesis and have a purity of at least 95 %. In this study 2D cultivation of MCF7 cells, phase-contrast and fluorescence microscopy, and a model of experimental growth of breast carcinoma Ca-755 in female hybrids of immunocompetent mice F1 (C57Bl/6 × DBA/2) were used.Results. Five derivatives of 3-hydroxyquinazoline, analogues of erastine, were studied in this work. The ferroptotic cell death was identified by the level of lipid peroxidation at the concentrations of 1/3 and 1/5 IC50. The level of lipid peroxidation induced by compound 3 was comparable with the activity of erastin in MCF7 cells at both 1/3 and 1/5 of IC50, the activity of the other four quinazoline derivatives was 50–70 % of the activity of erastin. In in vivo experiments at a dose of 30 mg/kg the antitumor efficacy of the compound 3 was higher than that of erastin at the same dose.Conclusion. The data obtained suggest that quinazoline derivative 3 might be considered as a promissisng antitumor agent to treat breast cancer.
Life Cycle Assessment of a Coke Cleaning Agent
Authors:   Key Laboratory for Green Chemical Process of Ministry of Education, Hubei Key Laboratory of Novel Chemical Reactor and Green Chemical Technology, School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Hubei, China, Gong Yu , Yang Changyan , Qu Yinhang , Li Jiayi , Yang Bohan , Ding Yigang , Zhang Bo
Published: March 2022

The life cycle assessment of the coke cleaning agent developed by a university-enterprise cooperation project was conducted. This cleaning agent has the characteristics of phosphorus-free, environmentally friendly, and broad market prospects. The life cycle assessment of the established model showed that the GWP of producing 1kg of coke cleaning agent is 1.19 kg CO2 eq, PED is 13.17 MJ, WU is 186.74 kg, AP is 3.63E-03 kg SO2 eq, ADP is 7.75E-05 kg antimony eq, EP is 1.30E-03 kg PO43-eq, RI is 1.16E-03 kg PM2.5 eq, ODP is 4.63E-06 kg CFC-11 eq, and POFP is 1.85E-03 kg NMVOC eq .The uncertainty of the results is between 4.20% and 24.05%. The carbon footprint (GWP) analysis showed that the production process of isotridecanol polyoxyethylene ether, isopropanol, fatty alcohol polyoxyethylene ether M and isodecanol polyoxyethylene ether contributed significantly. The average sensitivity analysis showed that the most influential processes were sodium lauryl amphoacetate, isopropanol, and tripropylene glycol methyl ether.
PANDEMİ SÜRECİNDE GÖÇMENLERLE ARAŞTIRMA YÜRÜTMEK: NİTELİKSEL YÖNTEMDE ‘YENİ NORMAL’ ÜZERİNE
Authors: KÖŞER AKÇAPAR Şebnem , ÇALIŞAN Aysima
Published: March 2022

COVID-19 salgını ve bu kapsamdaki fiziki mesafe önlemleri sonucu, araştırmalarında nitel ve karma yöntem benimseyen sosyal bilimciler, bu dönemde katılımcılara, sahaya ve kaynaklara erişme hususunda zorluklarla karşılaşmıştır. Bu zorlukların aşılmasında, bilgi ve iletişim teknolojilerinin sunduğu fırsatlar kadar araştırma tasarımlarının pandemi koşullarına uyarlanmasını sağlamak da önemli bir rol oynamıştır. Teknolojinin bu noktada kolaylaştırıcı bir araç olarak üstlendiği görev, göçmenler ve mülteciler gibi kırılgan gruplar ile 2020 ve 2021 yıllarında yürüttüğümüz iki farklı çalışmada, hem araştırma tasarımımızı pandemi koşullarına uyarlayarak veri toplamamıza hem de geleneksel ve çevrimiçi yöntemleri karşılaştırarak bir yöntem tartışması yapmamıza olanak vermiştir. Bu karşılaştırmaya göre, pandemi koşullarında geleneksel ve çevrimiçi yöntemle araştırma yürütmenin fırsatlar sunmakla beraber, bazı etik sorunlar yarattığı; çevrimiçi görüşmelerin araştırma nesnesinin dijital bölünmedeki imkân/sınırlılık konumuna göre kapsamlı veri toplanmasını engellediği ve çalışılan grubun düşük temsiliyet riskinin ortadan kalkmasının zorlaştığı saptanmıştır. Sonuç olarak, pandemi ile gündeme oturan nitel yöntemdeki yeni normal tartışmalarında, geleneksel ve çevrimiçi yöntemlerin metodolojik fırsatlarının ve zorluklarının değerlendirilerek başarıyla birleştirildiği melez yöntemlerin kullanılmasının gerekli ve kaçınılmaz olduğu vurgulanmıştır.
COVID-19 TANISININ HASTALAR ÜZERİNDEKİ SOSYAL ETKİLERİNİ ARAŞTIRMAK: KÜRESEL SALGINDA YENİ ARAŞTIRMA OLANAKLARI
Authors: ALTINIŞIK ERGUR Göksel , KABAKCI Enes
Published: March 2022

COVID-19 küresel salgını söz konusu olduğunda, sosyali bu denli etkileyen bir süreci incelemek için gereksinim duyulan araştırma yöntemlerinin çeşitlenmesi şaşırtıcı değildir. Alışılagelen pratiklerin –hastalığın bulaşma riski açısından– güvenli olmadığı ya da çeşitli kısıtlamalar nedeniyle sürdürülmesinin olanaksızlaştığı mevcut durumda iki olasılık gündeme gelmektedir: (a) süregelen pratiklere belirsiz bir süre için ara vermek ya da (b) bulaşıcı hastalıkla ilişkili riskler olmaksızın araştırma yapmanın temel ilkelerinden ödün verilmeden uyarlanan yeni teknik ve yöntemlere başvurmak. Böylece iletişimi hastalık bulaşma risklerini ortadan kaldırarak sürdürmeye olanak tanıyan sanal ortamlar, sosyal bilim araştırmalarında geniş bir kullanım alanı bulmuştur. Nitel araştırma süreçlerine çevrimiçi anket ve mülakat uygulamaları çok daha yoğun bir şekilde dâhil olmuştur. Belirli durumlarda çevrimiçi –görüntülü– görüşmelerin, söylem analizine dayanan nitel araştırma yöntemleri açısından bazı yararları olduğu düşünülebilir. Bu şekilde derinlemesine görüşme yapılarak COVID-19 küresel salgınının toplumsal etkileri üzerine gerçekleştirdiğimiz ve sosyoloji yüksek lisans tezi olarak sunduğumuz araştırmamızın evreni, küresel salgının ilk üç ayında Türkiye genelinde hastanede yatarak tedavi gören COVID-19 hastalarından oluşturmaktadır. Bu makalede, araştırma bulgularından ziyade değişen saha kavramı ve veri toplama teknikleri, yeni araçların sunduğu imkânlar ve kısıtlılıklar, araştırmacı ve katılımcıya güven, etik kodların gözden geçirilme gerekliliği gibi konuların değerlendirilmesi amaçlanmaktadır. Deneyim birikimi aktarılırken aynı zamanda ilişkili kavramların bilimsel yayınlar eşliğinde tartışılması, nitel araştırma tasarlayacak bilim insanlarına katkı sunmaya yöneliktir. Küresel salgın sürecindeki bu araştırma deneyimimiz, çevrimiçi derinlemesine görüşme tekniğinin; sahaya erişme ve yüz yüze görüşme yapmak için maliyeti azaltan, seyahat gerekliliğini ortadan kaldıran, etik ve araçsal açılardan geleneksel yöntemlerin yerini almaya aday bir seçenek olduğunu göstermiştir.
COVID-19 SALGIN GÜNLERİ: ‘KAYGAN ZEMİNDE’ GENÇLERLE ÇEVRİMİÇİ SAHA DENEYİMİ
Authors: SIRMA Çiğdem Sema
Published: March 2022

31 Aralık 2019 tarihinde Çin Halk Cumhuriyeti’nin Wuhan kentinde ortaya çıkan Yeni Koronavirüs (SARS-CoV-2) küresel salgınının ilk vakaları Ülkemizde 10 Mart 2020 tarihinde görülmüştür. Salgına bağlı olumsuz sonuçlar dünya genelinde halen devam etmektedir. COVID-19 Salgını; bireyleri yaşları, sosyo-ekonomik düzeyleri, meslekleri ve cinsiyetlerine bağlı olarak farklı şekillerde etkilemektedir. Geçirdiğimiz dönüşümü sosyolojik bakış açısı ile anlamak amacıyla Başkent Üniversitesi Sosyal ve Beşeri Bilimler Bilimsel Araştırma ve Yayın Etiği Kurulu’ndan 02/07/2020 tarihli ve 18524 sayılı izinle “Yeni Koronavirüs (COVID-19) Salgını Sürecinde Gençlerin Beden Memnuniyetlerinin İncelenmesi” başlıklı araştırmamı tamamladım. Araştırmanın metodolojik kabulü, yorumsamacı yaklaşımın temel vurgusu olan anlama çabasına dayanmaktadır. COVID-19 Salgını’nın seyrindeki belirsizlikler (salgının ne kadar süreceğinin belirsizliği, vaka sayılarının artma ihtimaliyle birlikte alınabilecek seyahat kısıtlaması önlemi ve tam kapanma) nedeniyle gündelik hayattaki değişimin yanı sıra saha dinamiklerinde de değişimler yaşanmıştır. Belirtmiş olduğum nedenlerle yüz yüze gerçekleştirdiğim saha araştırmalarından farklı olarak bu araştırma yarı yapılandırılmış görüşme formu aracılığıyla çevrim içi olarak tamamlanmıştır. Araştırmanın saha aşaması on altı katılımcı ile yaklaşık olarak bir yılda yürütülmüştür. Bu çalışmada salgın koşulları altında; çevrim içi nitel araştırmada katılımcılara ulaşabilmek için araştırmaya katılım daveti yazımı, aydınlatılmış onam, çevrim içi ara yüzün yarattığı uzaklığı/yabancılığı ortadan kaldırarak genç katılımcılarla yakınlık kurabilmek, genç katılımcılarla uyumu sağlayarak katılımcıların güvenini kazanabilmek, görüşmelerin internet üzerinden yapılmasının imkân ve sınırlılıklarıyla birlikte veri güvenliğini sağlamanın etik boyutları ele alınmıştır.
PANDEMİ SÜRECİNDE ARAŞTIRMA ETİĞİ VE DİJİTAL BÖLÜNME EKSENİNDE BİR ÇALIŞMA ÖRNEĞİ: ENGELLİ BİREYLER VE ANNELERİNİN YAŞAM KALİTELERİ
Authors: ÖZER TEKİN N. Beril , SÜNGÜ Büşra , AKINCI AYDOĞAN Aynur , ÖZER Dilara
Published: March 2022

Bu çalışmada Türkiye Bilimsel ve Teknolojik Araştırma Kurumunun (TÜBİTAK) 1001 COVID-19 özel çağrılı programı doğrultusunda gerçekleştirilen bir proje “araştırmanın ve veri toplamanın yeni yolları; araştırma etiği ve dijital bölünme” bakış açısından incelenmiştir. Araştırma problemi doğrultusunda “Pandemi sürecinde engelli bireylerle yapılan çevrimiçi araştırmalarda araştırma etiğinin ve kapsayıcılığın yeni kuralları neler olmalıdır?” sorusuna yanıt aranmıştır. Bu araştırmada TÜBİTAK tarafından desteklenen proje kapsamında görev alan üç araştırmacı, iki klinik psikolog ve bir beden eğitimi öğretmeni ile yarı-yapılandırılmış soru formu doğrultusunda görüşmeler yapılmıştır. Pandemi sürecinde gerçekleştirilen proje; araştırmacılar, uygulayıcılar ve katılımcılar açısından yeni ve farklı deneyimlerin yanı sıra zorlukları da beraberinde getirmiş, proje süreci içinde katılımcıların ihtiyaçlarına ve araştırma etiğine uygun olarak çeşitli stratejiler geliştirilmiştir. Çevrimiçi destek eğitim hizmetleri; internet erişimi, akıllı cihazı/bilgisayarı ve yeterli internet paketi olan kesimler (evde bulunma zorunluluğu olan, yaşlı/hasta/ağır engeli olan bireyler ve bu bireylere bakım veren kişiler) için elverişli olurken, bu olanaklara sahip olmayan kesimlerin ise bu hizmetlerden dışlanma riskini oluşturmaktadır. Eğitime erişimden dışlanma engelli bireylerin dezavantajlarını daha da derinleştirmekte ve fırsat eşitliğini güçleştirmektedir. “Dijital bölünme” ve “kesişimsellik” bu sınırlılıkların ve fırsat eşitsizliğinin anlaşılması açısından önemli kavram setleridir. Sonuç olarak, internet erişimi olmayan engelli bireylerin ve ailelerinin mevcut durumlarında sahip oldukları kırılganlıkların derinleşmesini önlemek için ekonomik yönden dezavantajlı kişilere teknolojik araç ve internet desteğinin sağlanması oldukça büyük önem taşımaktadır.
PENERAPAN ANALISIS JALUR (PATH ANALISIS) DALAM PEMBELAJARAN BAHASA ARAB
Authors: Suparmanto Suparmanto , Hudatullah Ruwaida
Published: March 2022

This research at Madrasah Aliyah Darul Muhajirin Praya  central Lombok  NTB. An educational institution under the Darul Muhajiri Islamic Boarding School (Ponpes). this research used the Path Analysis method conceptually and theoretically, from the concept of analysis, multivariant statistics, to the stages of path analysis modeling, it is expected to provide an understanding of path analysis. In its presentation,the researcher will discuss the relationship between learning motivation, creativity, learning style and teacher professionalism on student achievement. In application, there are several relevant software tools to help statistical analysis of the Structural Equation Model (SEM) and path analysis, namely: AMOS, LISREL, EQS, RAINOVA, and others. The author chose LISREL (Linear Structural Relation) version 9.1 Student Edition because it is easy to use and understand.
PROBLEMATIKA LATAR BELAKANG PENDIDIKAN MAHASISWA DAN IMPLIKASINYA DALAM PEMBELAJARAN BAHASA ARAB INTENSIF
Authors: Sehra Anisah Satus
Published: March 2022

Perbedaan latar belakang mahasiswa UIN Sunan Ampel sebelum melanjutkan studinya diperguruan tinggi tersebut menjadi kendala saat proses belajar-mengajar di kelas intensif bahasa Arab. pasalnya semua mahasiswa baru dituntut untuk mengikuti pembelajaran kelas Intensif tersebut. mau tidak mau mereka yang berasal dari sekolah umum harus mengikuti pembelajaran ini, Sehingga mereka akan merasa tertinggal dari teman-teman lainnya yang berasal dari pondok pesantren maupun Madrasah Aliyah. Penelitian ini mengusut tentang problematika yang terjadi pada mahasiswa UIN Sunan Ampel tepatnya di Febi (Fakultas Ekonomi Bisnis) Kelas Intensif bahasa Arab dari segi kendala yang terjadi pada Mahasiswa saat proses pembelajaran dan strategi yang diambil oleh dosen pembimbing untuk mengatasi permasalahan yang terjadi. Penelitian ini bersifat deskriptif-kualitatif dan penelitian lapangan. Sedangkan data penelitian diperoleh melalui metode angket dan wawancara.
Socioeconomic determinants of hunters’ participation in bush meat trade in Ibadan Oyo State Nigeria
Authors: Olunusi Bright , Lameed Gbolagade Akeem , Olunusi Patience Abosede , Olawumi Akinyode Timothy
Published: March 2022

This study investigated the socio-economic determinants of hunters’ participation in bush meat trade in Ibadan metropolis. Egbeda Local Government and Oluyole Local Government were purposively selected based on the intensity of bush meat trade there. Thirty percent of the population of registered hunters in these Local Government areas were randomly selected. A total of 126 respondents were interviewed through the use of a semi-structured questionnaire. Data obtained were analyzed through descriptive statistics and inferential analysis. The result revealed that (100%) of the respondents were men with majority (93.7%) of them within the age of 20-50 years. Majority (61%) had primary education while others (38%) had secondary education. Forty-four percent, 35% and 21% had 11-15, above 15 and below 10 years working experience respectively. More than half (61.5%) of the respondents engaged in hunting as their primary occupation while 14.3% combined farming with hunting. The average weekly profit made by hunters’ ranges from N4,000 to N50,000. Pearson Correlation analysis shows no significant relationship between years of experience and weekly profit (p<0.05). It also showed a statistically significant relationship between weekly profit and the months of highest abundance of bush meat to hunters (p<0.05). The study concludes that wildlife trade in the study area is influenced by level of education, limited alternate source of income and the profitability of the trade. The study recommends that the Government should implement working policies that will help to regulate and reduce over exploitation of wildlife; enhance the efficiency of wildlife trade and ensure its continuity.
Germinação de sementes de Handroanthus serratifolius (Vahl) S. O. Grose em substrato contendo resíduos agroindustriais
Authors: Soares Carolina Rafaela Barroco , Rocha Karen Janones da , Tronco Kenia Michele de Quadros
Published: March 2022

A Agricultura tem grande influência na economia rondoniense, mas o setor gera resíduos que podem ter diferentes destinações. E uma alternativa promissora para o destino final desses resíduos é o seu uso como substratos, minimizando assim impactos social, econômico e ambiental. O objetivo do trabalho foi avaliar os substratos obtidos a partir de diferentes concentrações resíduos agroindustriais, na germinação de Handroanthus serratifolius (Vahl) S. O. Grose. O delineamento utilizado foi o de blocos casualizados, cinco tratamentos e quatro repetições. Os tratamentos resultaram em diferentes combinações de areia e resíduo agroindustrial: T1 – 0%:100% (testemunha); T2 – 75%:25%; T3 – 50%:50 %; T4 – 25%:75%; e T5 – 0%:100%. Diariamente, foi avaliada a porcentagem de germinação (G%) e, após a estabilização da germinação aos 27 dias, foram calculados o índice de velocidade de germinação (IVG), tempo médio de germinação (TMG) e velocidade média de germinação (VMG) das sementes e as médias de germinação foram submetidas aos testes normalidade, homogeneidade a 5% de significância e análise de variância ao teste de Tukey (P ≥ 0,95). A porcentagem de germinação variou de 9% a 71%, e foi verificado 100% de sanidade das sementes e ausência de plântulas anormais. Verificou-se que o tratamento 2 apresentou diferença significativa entre os demais tratamentos, o substrato com os melhores resultados foi o T2 (G% = 71%; IVG =11; TMG = 17 dias; VMG = 0,0606 sementes.dia-1). O substrato com 25% resíduos + 75% areia destacou-se dos demais tratamentos, resultando nos melhores resultando na melhor germinação.
Precision Shut-In and Pressure Control Drilling in Injection Wells Around Adjustment Well Based on Injection-Production Data Mining
Authors: Zhong Liguo , Hao Tongchun , Xu Jie , Zhang Xiaocheng , Wang Xiaopeng , Xie Tao , Lin Tao , Zhang Lei
Published: March 2022

Affected by the surrounding injection and production wells, the formation near the infill adjustment well is in an abnormal pressure state, and drilling and completion operations are prone to complex situations and accidents such as leakage and overflow. The conventional shut down method is to close all water injection wells within 500 meters from the adjustment well to ensure the safety of the operation, but at the same time reduce the oil field production. This paper proposes a design method for shut-in of water injection wells around adjustment wells based on injection-production data mining. This method is based on the influence of correlation of complex pressure wells under injection and production conditions, and uses water injection index and fluid production index as research objects. Data mining methods are used to find highly correlated wells for precise adjustment instead of conventional adjustment. This method was applied to 20 infill adjustment wells in the Penglai Oilfield in Bohai Sea. The correlation between injection and production wells was calculated using the water injection index and fluid production index of more than 500 injection wells and production wells. Controlling the precise shut-in of highly correlated wells ensures that well pressures are kept within safe limits during drilling and completion operations and that no abnormalities occur. Low-relevant wells do not take shut-in adjustment measures. After a single adjustment well is drilled, the surrounding injection wells can increase the water injection volume by more than 5000m3. This method achieves accurate shut-in for water injection wells that are highly correlated with the adjustment well. Under the premise of ensuring the safety of drilling operations, the impact of adjusting drilling and completion on oilfield development is minimized, and oilfield production efficiency is improved. It has good application and promotion value.