bluuebunny/crossref_metadata_2025 huggingface dataset:
Formulation Strategies for Improving the Stability and Bioavailability of Vitamin D-Fortified Beverages: A Review
Authors: Vieira Elsa F. , Souza Suene
Published: March 2022

Vitamin D is a lipophilic bioactive that plays an important role in bone health. Fortification of beverages, such as milk, fruit juices, teas, and vegetable drinks, could be an efficient strategy to prevent vitamin D deficiency and its associated effects on health. This review summarizes the current understanding of beverage fortification strategies with vitamin D and the resulting effects on the stability, bioaccessibility, and sensory properties of the formulated products. The direct addition technique has been the conventional approach to fortifying beverages. In addition, encapsulation has been pointed out as a desirable delivery approach to increase stability, preserve bioactivity, and enhance the absorption of vitamin D in beverage systems. The literature reports the potential applicability of several methods for encapsulating vitamin D in beverages, including spray drying, micro/nanoemulsions, nanostructured lipid carriers, liposomes, and complexation to polymers. Some of these delivery systems have been assessed regarding vitamin D stability, but there is a lack of kinetic data that allow for the prediction of its stability under industrial processing conditions. Moreover, in some cases, the applicability of some of these delivery systems to real beverages as well as the in vivo efficacy were not evaluated; thus, fortification strategies with a global outreach are lacking.
Application of the Fractional Riccati Equation for Mathematical Modeling of Dynamic Processes with Saturation and Memory Effect
Authors: Tverdyi Dmitriy , Parovik Roman
Published: March 2022

In this study, the model Riccati equation with variable coefficients as functions, as well as a derivative of a fractional variable order (VO) of the Gerasimov-Caputo type, is used to approximate the data for some physical processes with saturation. In particular, the proposed model is applied to the description of solar activity (SA), namely the number of sunspots observed over the past 25 years. It is also used to describe data from Johns Hopkins University on coronavirus infection COVID-19, in particular data on the Russian Federation and the Republic of Uzbekistan. Finally, it is used to study issues related to seismic activity, in particular, the description of data on the volumetric activity of Radon (RVA). The Riccati equation used in the mathematical model was numerically solved by constructing an implicit finite difference scheme (IFDS) and its implementation by the modified Newton method (MNM). The calculated curves obtained in the study are compared with known experimental data. It is shown that if the model parameters are chosen appropriately, the model curves will give results that correlate well with real experimental data. Moreover, with other parameters of the model, it is possible to make some prediction about the possible course of the considered processes.
Photoresponsive Gelation of Four-Armed Poly(ethylene glycol) with Photodimerizable Groups
Authors: Okihara Masaaki , Okuma Kohei , Kawamura Akifumi , Miyata Takashi
Published: March 2022

Standard hydrogels prepared by free radical polymerization (FRP) have heterogeneous structures with a wide mesh size distribution, which affect their mechanical and separation properties. Recent research has identified four-armed poly(ethylene glycol) (tetra-PEG) as a solution to this problem. tetra-PEG gels with a homogeneous network can be prepared and applied as high-strength gels and cell-culture substrates by reacting two types of tetra-PEG with different reactive groups at the ends. In this study, we report a photoresponsive tetra-PEG that undergoes a phase transition from a sol to a gel state in response to light. tetra-PEGs containing cinnamoyl and maleimide groups at the ends of the four-armed chains were found to gel when exposed to light. The effects of polymer concentration and light irradiation time on the gelation of tetra-PEG containing photodimerization groups were investigated. The results showed that the elastic modulus of the gel increased with the increase in the light irradiation time.
The Complete Mitochondrial Genome of the Chicken Body Louse, Menacanthus cornutus, and Evolutionary Patterns of Extensive Gene Rearrangements in the Mitochondrial Genomes of Amblycera (Psocodea: Phthiraptera)
Authors: Gong Siyu , Xu Ye , Xu Shiwen , Liang Yanxin , Tian Li , Cai Wanzhi , Li Hu , Song Fan
Published: March 2022

Animal mitochondrial (mt) genomes are typically double-strand circular DNA molecules, but diverse structural variations have been widely found in multiple groups. In parasitic lice (Phthiraptera), the structure of mt genomes varies remarkably across all five suborders. In this study, we reported the complete mt genome of a chicken body louse, Menacanthus cornutus, which has a typical single circular mt chromosome and drastic mt gene rearrangements. This mt genome is 15,693 bp in length, consisting of 13 protein-coding genes, 23 tRNA genes, 2 rRNA genes, and a control region. A comparison with a typical insect mt genome suggested that two highly similar trnM are present in the mt genome of M. cornutus. Moreover, almost every single gene was rearranged, and over half of mt genes were inverted. Phylogenetic analyses inferred from the mt genome sequences supported the monophyly and position of Amblycera. Mapped over the phylogenetic relationships of Amblycera, we identified two inversion events for the conserved gene blocks in Boopidae and Menoponidae. The inverted ND4L-ND4 was likely a synapomorphic rearrangement in Menoponidae. Our study demonstrated the importance of sequencing mt genomes for additional taxa to uncover the mechanism underlying the structural evolution of the mt genome in parasitic lice.
Association of Myocardial Infarction with CDKN2B Antisense RNA 1 (CDKN2B-AS1) rs1333049 Polymorphism in Slovenian Subjects with Type 2 Diabetes Mellitus
Authors: Tibaut Miha , Naji Franjo , Petrovič Daniel
Published: March 2022

Background: We examined the role of rs1333049 polymorphism of the CDKN2B Antisense RNA 1 (CDKN2B-AS1) on the prevalence of myocardial infarction (MI) in Slovenian subjects with type 2 diabetes mellitus (T2DM). Methods: A total of 1071 subjects with T2DM were enrolled in this retrospective cross-sectional case-control study. Of the subjects, 334 had a history of recent MI, and 737 subjects in the control group had no clinical signs of coronary artery disease (CAD). With logistic regression, we performed a genetic analysis of rs1333049 polymorphism in all subjects. Results: The C allele of rs1333049 polymorphism was statistically more frequent in MI subjects (p = 0.05). Subjects with CC genotype had a higher prevalence of MI than the control group in the co-dominant (AOR 1.50, CI 1.02–2.21, p = 0.04) and recessive (AOR 1.38, CI 1.09–1.89, p = 0.04) genetic model. Conclusions: According to our study, the C allele and CC genotype of rs1333049 polymorphism of CDKN2B-AS1 are possible markers of MI in T2DM subjects in the Slovenian population.
Assessment of Satisfaction with Health Services among Prisoners—Descriptive Study
Authors: Rogalska Anna , Barański Kamil , Rachwaniec-Szczecińska Żaneta , Holecki Tomasz , Bąk-Sosnowska Monika
Published: March 2022

Aim: The aim of the study was to assess the access of prisoners to healthcare services, as well as the level of satisfaction with the provided services and health assessment among prisoners. Methods: The research was conducted in one of the penitentiary centers in Poland among people jailed between 1 January to 31 January 2020. The response rate of the self-administrated questionnaire was 52.05% (469/901) participants. There were 389 men and 77 women. Results: Prisoners assessed access to health services including GP doctors, specialist doctors, dentists, and hospitals in 3 categories: “bad” ranged: 27.03–67.60%; “medium” ranged: 22.54–53.57%; “good” ranged: 7.02–33.96% depending on the type of arrest, but no statistical significance was demonstrated. Satisfaction with the health services defined as “bad” ranged: 25.00–61.11%; “medium” ranged: 18.97–55.56%; “good” ranged: 5.56–34.62% depending on the type of arrest but no statistical significance was demonstrated. Of 469 prisoners, 215 prisoners (45.84%) declared no addictions. The frequency of addiction does not differ depending on the place/type of punishment served (p = 0.9). In turn, 317 prisoners (68%) declared no chronic diseases. Conclusions: Most of the prisoners described access to health services as “bad”, except female prisoners from a semi-open facility. In turn, satisfaction with healthcare services was most often assessed as “bad”, except for temporarily arrested men and female prisoners from a semi-open facility.
The Case for Malnutrition Quality Measures and Nutrition-Focused Quality Improvement Programs (QIPs) in US Skilled Nursing Facilities
Authors: Arensberg Mary Beth , Brunton Cory , Richardson Brenda , Bolhack Scott
Published: March 2022

As skilled nursing in the United States moves to a value-based model, malnutrition care remains a critical gap area that is associated with multiple poor health outcomes, including hospital readmissions and declines in functional status, psychosocial well-being, and quality of life. Malnutrition is often undiagnosed/untreated, even though it impacts up to half of skilled nursing facility (SNF) residents, and COVID-19 infections/related symptoms have likely further increased this risk. In acute care, malnutrition quality measures have been both developed/tested, and nutrition-focused quality improvement programs (QIPs) have been shown to reduce costs and effectively improve care processes and patient outcomes. Less is known about such quality initiatives in SNF care. This perspective paper reviewed malnutrition-related quality measures and nutrition-focused QIPs in SNFs and nursing home care. It identified that although the Centers for Medicare & Medicaid Services (CMS) has had a nursing home Quality Assurance and Performance Improvement (QAPI) program for 10 years and has had SNF quality measures for nearly 20 years, there are no malnutrition-specific quality measures for SNFs and very few published nutrition-focused QIPs in SNFs. This represents an important care gap that should be addressed to improve resident health outcomes as SNFs more fully move to a value-based care model.
Predictors for Estimating Scars’ Internalization in Victims with Post-Traumatic Scars versus Patients with Postsurgical Scars
Authors: Mekeres Gabriel Mihai , Voiţă-Mekereş Florica , Tudoran Cristina , Buhaş Camelia Liana , Tudoran Mariana , Racoviţă Mariana , Voiţă Nuţu Cristian , Pop Nicolae Ovidiu , Marian Mihai
Published: March 2022

(1) Background: Scars are the consequence of physiological inherent healing processes of post-traumatic and surgical lesions with a psychological impact. Post-traumatic scarring may induce emotional and behavioral changes through social stigma. In this study we analyze the internalization of scars and their impact on hopelessness, depression, or the perception of social support in subjects with post-traumatic scars compared to people with surgical scars. (2) Methods: to research this suggested model, we analyzed data collected from 110 participants 61 women and 49 men, aged between 18 and 64 years; 55 participants had post-traumatically and 55 surgically acquired scars. They all were examined to assess the characteristics of scars, were asked to complete four psycho-social scales, and the results were compared. (3) Results: our results indicate that people with post-traumatic scars are oriented toward the internalization of scars, depending on their shape and size. We argue that hopelessness, appreciation of scars, age, and how scars are produced are important predictors of internalization. (4) Conclusions: the patient’s attitude toward the appearance of a scar is an indicator of how he/she will react in the future and it could predict the vulnerability to hopelessness. Finally, we nuance the impact of objective bodily harm on the psychological and moral suffering.
Applying Simulation Optimization to Minimize Drug Inventory Costs: A Study of a Case Outpatient Pharmacy
Authors: Chen Chia-Nan , Lai Chin-Hui , Lu Guan-Wei , Huang Ching-Chun , Wu Le-Jean , Lin Hui-Chuan , Chen Ping-Shun
Published: March 2022

Drug inventory management is an important part of hospital management. The large amounts of drug data in hospitals bring challenges to optimizing the setting values for the safety stock and the maximum inventory of each drug. This study combined a two-stage clustering method with an inventory policy (s, S) and established a simulation optimization model for the case hospital’s outpatient pharmacy. This research used the simulation optimization software Arena OptQuest, developed by Rockwell Automation Inc (Rockwell Automation, Coraopolis, PA, USA), in order to determine the minimum and maximum values (s, S) of the best stock amounts for each drug under the considerations of cost and related inventory constraints. The research results showed that the minimum and maximum inventory settings for each drug in the simulation model were better than those set by the case outpatient pharmacy system. The average inventory cost was reduced by 55%, while the average inventory volume was reduced by 68%. The proposed method can improve management efficiency and inventory costs of hospital pharmacies without affecting patient services and increasing the inventory turnover rate of the drugs.
The Intriguing Connections between von Willebrand Factor, ADAMTS13 and Cancer
Authors: Colonne Chanukya K. , Favaloro Emmanuel J. , Pasalic Leonardo
Published: March 2022

von Willebrand factor (VWF) is a complex and large protein that is cleaved by ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13), and together they serve important roles in normal hemostasis. Malignancy can result in both a deficiency or excess of VWF, leading to aberrant hemostasis with either increased bleeding or thrombotic complications, as respectively seen with acquired von Willebrand syndrome and cancer-associated venous thromboembolism. There is emerging evidence to suggest VWF also plays a role in inflammation, angiogenesis and tumor biology, and it is likely that VWF promotes tumor metastasis. High VWF levels have been documented in a number of malignancies and in some cases correlate with more advanced disease and poor prognosis. Tumor cells can induce endothelial cells to release VWF and certain tumor cells have the capacity for de novo expression of VWF, leading to a proinflammatory microenvironment that is likely conducive to tumor progression, metastasis and micro-thrombosis. VWF can facilitate tumor cell adhesion to endothelial cells and aids with the recruitment of platelets into the tumor microenvironment, where tumor/platelet aggregates are able to form and facilitate hematogenous spread of cancer. As ADAMTS13 moderates VWF level and activity, it too is potentially involved in the pathophysiology of these events. VWF and ADAMTS13 have been explored as tumor biomarkers for the detection and prognostication of certain malignancies; however, the results are underdeveloped and so currently not utilized for clinical use. Further studies addressing the basic science mechanisms and real word epidemiology are required to better appreciate the intriguing connections between VWF, ADAMTS13 and malignancy. A better understanding of the role VWF and ADAMTS13 play in the promotion and inhibition of cancer and its metastasis will help direct further translational studies to aid with the development of novel cancer prognostic tools and treatment modalities.
Effects of Nonthermal Plasma (NTP) on the Growth and Quality of Baby Leaf Lettuce (Lactuca sativa var. acephala Alef.) Cultivated in an Indoor Hydroponic Growing System
Authors: Carmassi Giulia , Cela Fatjon , Trivellini Alice , Gambineri Francesca , Cursi Lamberto , Cecchi Antonio , Pardossi Alberto , Incrocci Luca
Published: March 2022

The aim of this research was to develop an effective protocol for the application of nonthermal plasma (NTP) technology to the hydroponic nutrient solution, and to investigate its effects on the growth and quality of baby leaf lettuce (Lactuca sativa var. acephala Alef.) grown in a hydroponic growing system (HGS) specifically designed for indoor home cultivation. Four HGSs were placed in separate growth chambers with temperature of 24 ± 1 °C and relative humidity of 70 ± 5%). Lettuce plants were grown for nine days in nutrient solutions treated with NTP for 0 (control) to 120 s every hour. Results of the first experiments showed that the optimal operating time of NTP was 120 s h−1. Fresh leaf biomass was increased by the 60 and 120 s NTP treatments compared to the control. Treating the nutrient solution with NTP also resulted in greater leaf content of total chlorophylls, carotenoids, total phenols, and total antioxidant capacity. NTP also positively influenced chlorophyll a fluorescence in Photosystem I (PSI) and photosynthetic electron transport. These results revealed that the NTP treatment of the nutrient solution could improve the production and quality of hydroponically grown baby leaf lettuce.
In Search for Comparability: The PECUNIA Reference Unit Costs for Health and Social Care Services in Europe
Authors: Mayer Susanne , Berger Michael , Konnopka Alexander , Brodszky Valentin , Evers Silvia M. A. A. , Hakkaart-van Roijen Leona , Guitérrez-Colosia Mencia R. , Salvador-Carulla Luis , Park A-La , Hollingworth William , García-Pérez Lidia , Simon Judit ,   on behalf of the PECUNIA Group
Published: March 2022

Improving the efficiency of mental healthcare service delivery by learning from international best-practice examples requires valid data, including robust unit costs, which currently often lack cross-country comparability. The European ProgrammE in Costing, resource use measurement and outcome valuation for Use in multi-sectoral National and International health economic evaluAtions (PECUNIA) aimed to harmonize the international unit cost development. This article presents the methodology and set of 36 externally validated, standardized reference unit costs (RUCs) for five health and social care services (general practitioner, dentist, help-line, day-care center, nursing home) in Austria, England, Germany, Hungary, The Netherlands, and Spain based on unambiguous service definitions using the extended DESDE PECUNIA coding framework. The resulting PECUNIA RUCs are largely comparable across countries, with any causes for deviations (e.g., country-specific scope of services) transparently documented. Even under standardized methods, notable limitations due to data-driven divergences in key costing parameters remain. Increased cross-country comparability by adopting a uniform methodology and definitions can advance the quality of evidence-based policy guidance derived from health economic evaluations. The PECUNIA RUCs are available free of charge and aim to significantly improve the quality and feasibility of future economic evaluations and their transferability across mental health systems.
SARS-CoV-2 Seroprevalence Survey in Grocery Store Workers—Minnesota, 2020–2021
Authors: Vachon Madhura S. , Demmer Ryan T. , Yendell Stephanie , Draeger Kathryn J. , Beebe Timothy J. , Hedberg Craig W.
Published: March 2022

Grocery workers were essential to the workforce and exempt from lockdown requirements as per Minnesota Executive Order 20–20. The risk of COVID-19 transmission in grocery settings is not well documented. This study aimed to determine which factors influenced seropositivity among grocery workers. We conducted a cross-sectional study of Minnesota grocery workers aged 18 and older using a convenience sample. Participants were recruited using a flyer disseminated electronically via e-mail, social media, and newspaper advertising. Participants were directed to an electronic survey and were asked to self-collect capillary blood for IgG antibody testing. Data were analyzed using logistic regression and adjusted for urbanicity, which confounded the relationship between number of job responsibilities in a store and seropositivity. Of 861 Minnesota grocery workers surveyed, 706 (82%) were tested as part of this study, of which 56 (7.9%) tested positive for IgG antibodies. Participants aged 65–74 years had the highest percent positivity. Having multiple job responsibilities in a store was significantly associated with seropositivity in our adjusted model (OR: 1.14 95% CI: 1.01–1.27). Workplace factors influenced seropositivity among Minnesota grocery workers. Future research will examine other potential factors (e.g., in-store preventive measures and access to PPE) that may contribute to increased seropositivity.
Assessment of Actual Weight, Perceived Weight and Desired Weight of Romanian School Children-Opinions and Practices of Children and Their Parents
Authors: Trandafir Anda-Valentina , Fraseniuc Maria , Lotrean Lucia Maria
Published: March 2022

Objective: Children and parental awareness regarding weight is linked to the development and management of overweight and obesity. The aim of this study is to assess the actual weight, perceived weight, and desired weight of Romanian school children. Methods: A cross-sectional study was conducted in 2019 in seven schools from two counties of Romania and included 880 pupils aged between 10 and 15 years old and 665 parents. We administrated confidential questionnaires to the participants, and we measured children’s weight and height during school activities. Results: A total of 61.0% of pupils had normal weight, 7.4% were underweight, and 31.6% were overweight or obese. A total of 66.7% of normal weight children, 56.5% of overweight children, and 40% of underweight children perceived their weight accurately. Regarding parents, a majority correctly appreciated the weight of their normal weight children and only a third appreciated correctly the body weight of their underweight and overweight children. Factors such as body mass index, gender, weight related behaviors, parents’ estimation about their children’s weight, discussions of weight topics inside family, and bullying, cyberbullying and exclusion from groups were associated with misperceptions. Conclusion: The study provides useful information for health education activities targeting both children and their parents regarding appropriate body weight management of children.
Lost in Transition: The Need for a Strategic Approach to Facilitate Job Market Integration of Internationally Educated Physicians through Alternative Careers
Authors: Turin Tanvir C. , Chowdhury Nashit , Lake Deidre
Published: March 2022

Skilled migration has been an important part of the socioeconomic development and progression of many industrialised Western countries. However, successful migration includes facilitating sociocultural and professional environments, policies, and practices in a way that utilizes the skills of migrants appropriately. Internationally educated physicians (IEPs) are an important part of the health and wellness care program of these countries. Nevertheless, because of regulations and limited available positions, many of these migrated physicians find they cannot enter into the healthcare workforce as practicing physicians. Utilizing their health-related knowledge and skills through nonphysician careers in health and wellness is a beneficial way to integrate these highly skilled professionals into a country’s socioeconomic flow. Despite the availability of alternative careers for IEPs, we identified that these paths are often not explored and facilitated, resulting in un/underemployment and wastage of these highly skilled human resources. A lack of willingness among IEPs, under/overestimation of their transferable skills by themselves and by potential employers, and a lack of strategic support and career guidance are prominent obstacles. A collaborative approach from multiple sectors, including academics, integration service providers, and policy makers, is needed to create awareness of these alternative opportunities and facilitation of the socioeconomic integration of IEPs.
Predicting Adolescent Internet Gaming Addiction from Perceived Discrimination, Deviant Peer Affiliation and Maladaptive Cognitions in the Chinese Population: A Two-Year Longitudinal Study
Authors: Wang Likun , Li Meijin , Xu Yang , Yu Chengfu
Published: March 2022

A robust positive association between perceived discrimination and Internet gaming addiction (IGA) among adolescents has been demonstrated by existing research; however, the mediating mechanisms underlying this relationship remain largely unknown. This study, grounded in the cognitive–behavioral and social development models, examined whether deviant peer affiliation and maladaptive cognitions mediated the predictive effect of perceived discrimination on adolescent IGA. Six-hundred-and-sixty students (Meanage = 13.43 years; 367 female participants) recruited from southern China participated in four assessments (fall 7th grade, spring 7th grade, fall 8th grade, spring 8th grade). Participants completed a self-administered questionnaire that assessed their demographics, as well as questionnaire measures of perceived discrimination, deviant peer affiliation, maladaptive cognitions, and IGA. The structural equation model showed that fall 7th grade’s perceived discrimination positively predicted spring 7th grade’s deviant peer affiliation, which, in turn, increased fall 8th grade’s maladaptive cognitions, ultimately increasing spring 8th grade’s IGA. Moreover, the indirect effect of fall 7th grade’s perceived discrimination on spring 8th grade’s IGA via spring 7th grade’s deviant peer affiliation was also significant. The results suggested deviant peer affiliation and maladaptive cognitions as potential mediating mechanisms linking perceived discrimination to adolescent IGA. These findings have important implications for the prevention and intervention of adolescent IGA.
The Impact of a Grocery Store Closure in One Rural Highly Obese Appalachian Community on Shopping Behavior and Dietary Intake
Authors: Gillespie Rachel , DeWitt Emily , Slone Stacey , Cardarelli Kathryn , Gustafson Alison
Published: March 2022

Research has examined how the entry of grocery stores into neighborhoods influences dietary outcomes, yet limited evidence suggests a direct correlation between opening a store and changes in dietary intake. A factor that might influence individuals’ behavior more directly is the closing of a grocery store where residents shop. This study aims to examine how a grocery closure in a rural Appalachian high poverty county is associated with dietary intake. A cohort of n = 152 individuals were recruited to participate in a longitudinal study examining purchasing habits and dietary intake. At time point two, one year later, n = 74 individuals completed the survey via phone. Results indicate those that switched from shopping at a local grocery store to a supercenter significantly increased their dietary intake of fruit (0.2 ± 0.8), fruits and vegetables (1.4 ± 2.7), alcohol (grams) (17.3 ± 54.1), and tomato sauce (0.1 ± 0.3). A local grocery store closure was associated with a change in shopping behavior and dietary intake. Community-level interventions targeting dietary behaviors must account for neighborhood food environment influences, including grocery store availability. Policy aimed at improving food access in rural communities need to consider approaches to improving a variety of food venues with affordable healthy food, while addressing the evolving grocery shopping behaviors of consumers.
The Effect of Eight-Week Functional Core Training on Core Stability in Young Rhythmic Gymnasts: A Randomized Clinical Trial
Authors: Cabrejas Cristina , Solana-Tramunt Mónica , Morales Jose , Campos-Rius Josep , Ortegón Alberto , Nieto-Guisado Ainhoa , Carballeira Eduardo
Published: March 2022

It is suggested that core stability (CS) might improve rhythmic gymnasts’ performance. Nevertheless, the effect of core stability training (CST) in CS performance is not clear. Purpose: Evaluating the effect of an eight-week functional CST on young rhythmics gymnasts’ CS performance. Method: A sample of 45 young female rhythmic gymnasts from a competitive team (age = 10.5 ± 1.8 years, height = 144.1 ± 10.6 cm, weight 38.2 ± 8.9 kg, peak height velocity (PHV) = 12.2 ± 0.6 years) participated in the study. The participants were randomly allocated into the control group (CG) and experimental group (EG) and completed pre-tests and post-tests of specific CS tests using a pressure biofeedback unit (PBU). The CS was assessed by the bent knee fall out (BKFO), the active straight leg raise (ASLR) tests and the pelvic tilt test, all performed on the right and left sides. The EG (n = 23) performed an eight-week functional CST program based on rhythmic gymnastics (RG) technical requirements added to the traditional RG training sessions. Meanwhile, the CG (n = 22) received the traditional RG training sessions. Results: Mixed model analysis showed non-significant interaction effects; however, the ANOVA omnibus test showed a time effect (p < 0.05) in right BKFO (F1,42 = 4.60; p = 0.038) and both pelvic tilt tests (right F1,42 = 22.01, p < 0.001; left F1,42 = 19.13, p < 0.001). There were non-significant interaction effects. The fixed effects estimated parameters for right BKFO showed that both groups had less pressure variation after intervention compared with pre-intervention (β = −1.85 mmHg, 95%CI = [−3.54 to −0.16], t42 = −2.14, p = 0.038). Furthermore, the left pelvic tilt (β = 37.0 s, 95%CI = [20.4 to 53.6], t42 = 4.37, p < 0.001) improved 8.9 s more than the right pelvic tilt (β = 28.1 s, 95%CI = [16.3 to 39.8], t42 = 4.69, p < 0.001) considering both groups together. Conclusions: Adding a functional CST to regular training showed a trend in improving the performance of CS-related variables, which could help improve RG-specific performance. Coaches working with rhythmic gymnasts should consider adding a functional CST to regular training to improve CS performance leading to increased specific RG performance.
“It’s All Just Marketing”, a Qualitative Analysis of Consumer Perceptions and Understandings of Nutrition Content and Health Claims in New Zealand
Authors: Stuthridge Lucy , Alexander Donnell , Stubbe Maria , Eme Paul , Smith Claire
Published: March 2022

Nutrition content and health claims are widely used globally on both food labels and in food advertising. This study explored how New Zealand consumers understand, perceive, and use nutrition content and health claims on food labels. A qualitative approach was used with semi-structured in-depth online interviews and in-person focus groups including 49 participants, aged ≥25 years responsible for household food shopping. Transcripts were analysed using reflexive thematic analysis using inductive coding, with development of five themes—(1) aware of claims but did not use, (2) mistrust and scepticism, (3) confusion and misinterpretation, (4) using claims to guide food choice, and (5) not all claims are equal. For theme 1, price and habit were found to be the most influential in driving food choice. Underlying theme 2 was the perception by most of nutrition and health claims as marketing. Scepticism was exacerbated when nutrient claims were displayed on inherently unhealthy products. However participants with specific dietary requirements did find claims helpful. Restricting nutrient claims to foods meeting a healthy nutrient profile aligned to the existing Health Star Rating system, education about regulation and supporting claims with more contextual information may increase trust, the perceived value of claims and therefore their utility.
Emotional Intelligence, Psychological Well-Being and Burnout of Active and In-Training Teachers
Authors: Lucas-Mangas Susana , Valdivieso-León Lorena , Espinoza-Díaz Ivette Margarita , Tous-Pallarés Jordi
Published: March 2022

The main activating variables of psychological well-being and Emotional Intelligence that influence teachers include the process of evaluating well-being, their motivation, and their ability to perceive and regulate sources of stress and burnout. The relationship and influence of psychological well-being and emotional intelligence was analyzed with the adequate regulation of burnout. Those who participated included 386 active teachers (55%), and teachers in training (45%), studying for degrees in Pre-School and Primary Education, and Master’s degrees in Secondary Education Teacher Training of which 71.5% were women. The following were used: Psychological Well-Being Scales, Trait Meta-Mood Scale and the Spanish Burnout Inventory. Pearson’s correlation analysis and multiple regression analysis were performed. The results showed that enthusiasm for the teaching job is related to psychological well-being, especially domain of the environment and personal growth. Multiple regression analysis made it possible to establish a predictive model of well-being, showing that psychological well-being is the main adjustment predictor and/or the mismatch in the work of the teaching staff in both samples, through an adequate regulation of positive relationships, mastery of their environment and having a purpose in life.
Update on Cyber Health Psychology: Virtual Reality and Mobile Health Tools in Psychotherapy, Clinical Rehabilitation, and Addiction Treatment
Authors: Caponnetto Pasquale , Casu Mirko
Published: March 2022

(1) Background: we investigated and analyzed the most recent implementations of technology in the fields of psychotherapy, clinical rehabilitation, and addiction treatment. (2) Methods: from December 2021 to January 2022, we conducted a review aimed at identifying the recent implementations of technology in cyber health psychology, with particular reference to Virtual Reality in psychotherapy, mHealth tools in clinical rehabilitation, and smartphone applications in the treatment of addiction to substances of abuse, searching for relevant studies in the databases PubMed, Web of Science, Google Scholar, Health & Medical Collection, and APA PsycArticles. (3) Results: the tools analyzed are in constant development and are increasingly used, with good results, and further technological progress could lead to even better treatment outcomes; as far as mHealth tools and smartphone applications are concerned, anti-smoking Apps are the most widespread, followed by those for the treatment of alcohol use disorder, and there is no presence of Apps for the treatment of heroin, cocaine, or crack addiction. (4) Conclusions: the results of the review indicate that these technological tools are increasingly used and are, in principle, effective and have numerous advantages, including low cost and versatility.
“You Always Have It in the Back of Your Mind”—Feelings, Coping, and Support Needs of Women with Pathogenic Variants in Moderate-Risk Genes for Hereditary Breast Cancer Attending Genetic Counseling in Germany: A Qualitative Interview Study
Authors: Stracke Claudia , Lemmen Clarissa , Rhiem Kerstin , Schmutzler Rita , Kautz-Freimuth Sibylle , Stock Stephanie
Published: March 2022

Hereditary breast cancer accounts for approximately 30% of newly diagnosed breast cancer (BC) cases. Pathogenic variants in moderate-risk BC genes (MBCG) differ from those in high-risk genes in terms of associated cancer risks, affected organs, and available preventive options. Little is known about how MBCG pathogenic variant carriers who have attended post-test genetic counseling perceive their situation, how they cope with their situation, and which support needs they might have. Problem-centered, guided, individual interviews were conducted with twelve women carrying pathogenic variants in MBCG. The interview analysis was based on Mayring’s qualitative content analysis. The women were between 29 and 59 years old and carried pathogenic variants in the risk genes CHEK2 (n = 8), ATM (n = 1), or PALB2 (n = 3). Women reported a wide range of feelings, both positive (relief, calmness) and negative (overwhelm, fear, grief, guilt). All women applied strategies of emotion-focused coping to deal with this lifelong situation. Appraisal and evaluation of the affected mother’s coping might influence the patient’s own behavior and coping style. These results could be used during and after post-test genetic counseling to provide more needs-oriented counseling, and to help women in adjusting to and coping with being a pathogenic variant carrier.
Spatial Analysis of COVID-19 Vaccine Centers Distribution: A Case Study of the City of Jeddah, Saudi Arabia
Authors: Faisal Kamil , Alshammari Sultanah , Alotaibi Reem , Alhothali Areej , Bamasag Omaimah , Alghanmi Nusaybah , Bin Yamin Manal
Published: March 2022

The COVID-19 pandemic is one of the most devastating public health emergencies in history. In late 2020 and after almost a year from the initial outbreak of the novel coronavirus (SARS-CoV-2), several vaccines were approved and administered in most countries. Saudi Arabia has established COVID-19 vaccination centers in all regions. Various facilities were selected to set up these vaccination centers, including conference and exhibition centers, old airport terminals, pre-existing medical facilities, and primary healthcare centers. Deciding the number and locations of these facilities is a fundamental objective for successful epidemic responses to ensure the delivery of vaccines and other health services to the entire population. This study analyzed the spatial distribution of COVID-19 vaccination centers in Jeddah, a major city in Saudi Arabia, by using GIS tools and methods to provide insight on the effectiveness of the selection and distribution of the COVID-19 vaccination centers in terms of accessibility and coverage. Based on a spatial analysis of vaccine centers’ coverage in 2020 and 2021 in Jeddah presented in this study, coverage deficiency would have been addressed earlier if the applied GIS analysis methods had been used by authorities while gradually increasing the number of vaccination centers. This study recommends that the Ministry of Health in Saudi Arabia evaluated the assigned vaccination centers to include the less-populated regions and to ensure equity and fairness in vaccine distribution. Adding more vaccine centers or reallocating some existing centers in the denser districts to increase the coverage in the uncovered sparse regions in Jeddah is also recommended. The methods applied in this study could be part of a strategic vaccination administration program for future public health emergencies and other vaccination campaigns.
A Fuzzy Inference System for the Assessment of Indoor Air Quality in an Operating Room to Prevent Surgical Site Infection
Authors: Colella Ylenia , Valente Antonio Saverio , Rossano Lucia , Trunfio Teresa Angela , Fiorillo Antonella , Improta Giovanni
Published: March 2022

Indoor air quality in hospital operating rooms is of great concern for the prevention of surgical site infections (SSI). A wide range of relevant medical and engineering literature has shown that the reduction in air contamination can be achieved by introducing a more efficient set of controls of HVAC systems and exploiting alarms and monitoring systems that allow having a clear report of the internal air status level. In this paper, an operating room air quality monitoring system based on a fuzzy decision support system has been proposed in order to help hospital staff responsible to guarantee a safe environment. The goal of the work is to reduce the airborne contamination in order to optimize the surgical environment, thus preventing the occurrence of SSI and reducing the related mortality rate. The advantage of FIS is that the evaluation of the air quality is based on easy-to-find input data established on the best combination of parameters and level of alert. Compared to other literature works, the proposed approach based on the FIS has been designed to take into account also the movement of clinicians in the operating room in order to monitor unauthorized paths. The test of the proposed strategy has been executed by exploiting data collected by ad-hoc sensors placed inside a real operating block during the experimental activities of the “Bacterial Infections Post Surgery” Project (BIPS). Results show that the system is capable to return risk values with extreme precision.
Female Sexual Function in Twin Pregnancy
Authors: Fuchs Anna , Dulska Agnieszka , Bodziony Jakub , Szul Mateusz , Drosdzol-Cop Agnieszka
Published: March 2022

Introduction: The incidence of twin pregnancy is estimated at 1 per 80 single pregnancies. As the topic of sexual function among women with multiple pregnancy is insufficiently developed, we believe it is appropriate to raise this subject. Methods: A prospective study was conducted on 100 women during subsequent trimesters of pregnancy. Results: From a group of 100 women, 54 women were primiparous, while 46 women had a history of previous delivery. The mean overall FSFI (female sexual function index) was found to be 24.3 ± 6.1. Mean FSFI was the highest in the first trimester at 25.6. The result decreased successively to 24.8 ± 7 and 22.6 ± 8.4 in the second and third trimesters, respectively. The patient’s place of residence had a crucial impact on their FSFI score. The results were considerably higher for residents of small and medium towns or cities—24.4 ± 3.8 and 25.9 ± 4.9, respectively—while for those living in rural areas, the FSFI reached only 21.7 ± 5.4. Conclusions: The present study shows that the FSFI decreased throughout twin pregnancy. The lowest observed FSFI occurred in the third trimester, while the highest FSFI occurred during the first trimester.
A Simple Method to Quantify Outward Leakage of Medical Face Masks and Barrier Face Coverings: Implication for the Overall Filtration Efficiency
Authors: Chiera Silvia , Cristoforetti Alessandro , Benedetti Luca , Nollo Giandomenico , Borro Luca , Mazzei Lorenzo , Tessarolo Francesco
Published: March 2022

Face masking proved essential to reduce transmission of COVID-19 and other respiratory infections in indoor environments, but standards and literature do not provide simple quantitative methods for quantifying air leakage at the face seal. This study reports an original method to quantify outward leakage and how wearing style impacts on leaks and filtration efficiency. The amount of air leakage was evaluated on four medical masks and four barrier face coverings, exploiting a theoretical model and an instrumented dummy head in a range of airflows between 30 and 160 L/min. The fraction of air leaking at the face seal of the medical masks and barrier face coverings ranged from 43% to 95% of exhaled air at 30 L/min and reduced to 10–85% at 160 L/min. Filter breathability was the main driver affecting both leak fraction and total filtration efficiency that varied from 5% to 53% and from 15% to 84% at 30 and 160 L/min, respectively. Minor changes were related to wearing style, supporting indications on the correct mask use. The fraction of air leaking from medical masks and barrier face coverings during exhalation is relevant and varies according to design and wearing style. The use of highly breathable filter materials reduces air leaks and improve total filtration efficiency.
New Core-Shell Nanostructures for FRET Studies: Synthesis, Characterization, and Quantitative Analysis
Authors: Synak Anna , Adamska Elżbieta , Kułak Leszek , Grobelna Beata , Niedziałkowski Paweł , Bojarski Piotr
Published: March 2022

This work describes the synthesis and characterization of new core-shell material designed for Förster resonance energy transfer (FRET) studies. Synthesis, structural and optical properties of core-shell nanostructures with a large number of two kinds of fluorophores bound to the shell are presented. As fluorophores, strongly fluorescent rhodamine 101 and rhodamine 110 chloride were selected. The dyes exhibit significant spectral overlap between acceptor absorption and donor emission spectra, which enables effective FRET. Core-shell nanoparticles strongly differing in the ratio of donors to acceptor numbers were prepared. This leads to two different interesting cases: typical single-step FRET or multistep energy migration preceding FRET. The single-step FRET model that was designed and presented by some of us recently for core-shell nanoparticles is herein experimentally verified. Very good agreement between the analytical expression for donor fluorescence intensity decay and experimental data was obtained, which confirmed the correctness of the model. Multistep energy migration between donors preceding the final transfer to the acceptor can also be successfully described. In this case, however, experimental data are compared with the results of Monte Carlo simulations, as there is no respective analytical expression. Excellent agreement in this more general case evidences the usefulness of this numerical method in the design and prediction of the properties of the synthesized core-shell nanoparticles labelled with multiple and chemically different fluorophores.
Investigating the Short Peptidome Profile of Italian Dry-Cured Ham at Different Processing Times by High-Resolution Mass Spectrometry and Chemometrics
Authors: Cerrato Andrea , Aita Sara Elsa , Capriotti Anna Laura , Cavaliere Chiara , Montone Angela Michela Immacolata , Montone Carmela Maria , Laganà Aldo
Published: March 2022

Short peptides have been spiking interest owing to their significant contribution to the taste and functional properties of dry-cured ham. In this study, a suspect screening approach based on high-resolution mass spectrometry was employed for the comprehensive characterization of the short endogenous peptidome in dry-cured ham samples at different processing stages (14, 22, and 34 months). After careful manual spectra interpretation, a chemometric approach based on principal component analysis was employed for highlighting the differences between the three sets of samples. A total of 236 short peptide sequences was tentatively identified, including 173 natural short peptides and 63 sequences containing non-proteinogenic amino acids, the highest number ever reported for endogenous sequences in dry-cured ham. Samples in the latest processing stages presented a generally higher abundance of dipeptides, indicating residual proteolytic activity. Moreover, the several annotated modified short peptides, mainly pyroglutamination and lactoyl conjugation, allowed hypothesizing several reactions occurring over time. For the first time, several lactoyl-dipeptides were tentatively identified in dry-cured ham samples with maximum concentration in the late processing stage samples. The presented results significantly contribute to the understanding of the reaction involving short peptides that affect the sensory and functional properties of dry-cured ham.