bluuebunny/crossref_metadata_2025 huggingface dataset:
ПРОФЕСІЙНА КОМПЕТЕНТНІСТЬ МАЙБУТНІХ ФАХІВЦІВ МЕДИЧНОЇ ГАЛУЗІ ЯК ПЕДАГОГІЧНА ПРОБЛЕМА
Authors:   КВНЗ «Херсонська академія неперервної освіти», Кохановська О.В. , Кузьменко Ю.В. ,   Херсонський факультет Одеського державного університету внутрнішніх справ
Published: January 2025

У статті досліджено питання професійної компетентності майбутніх фахівців медичної галузі як педагогічної проблеми. Авторами розкрито поняття «компетенції» та «компетентності», значення компетентністного підходу в сучасній освіті. У статті наведено трактування понять «компетентність» і «професійна компетентність» різними науковцями, а також професійної компетентності майбутнього медичного фахівця як інтегральної системи ключових компетентностей – науково-дослідницької, організаційно-управлінської, проєктної, технологічної та педагогічної, які реалізуються через низку організаційних аспектів, міжособистісного спілкування, уміння працювати з інформацією та інформування критичного мислення, необхідного для вирішення типових і складних ситуативних завдань практичної спрямованості.
Звернено увагу на підвиди професійної компетентності медиків – функціональну, ситуативну, інтелектуальну, соціальну, які у своїй сукупності забезпечують готовність медика до практичної діяльності та відображають цілісність особистості, що має якісну фахову підготовку. У статті зазначено, що професійна компетентність майбутнього медика є складною системою, яку необхідно формувати поетапно від отримання та засвоєння теоретичних знань до формування «динамічного стереотипу» здійснення практичних навичок, наголошено на значущості рефлексії медика для здійснення ефективної практичної діяльності та якісного надання кваліфікованої медичної допомоги. Авторами акцентовано увагу на ролі мотивації у здобувачів, її значенні для формування медика як особистості, існуванні етико-деонтологічних відносин у колективі та значенні комунікації між всіма учасниками лікувально-діагностичного процесу.
У статті виділено перспективи подальших досліджень, які полягають у подальшій деталізації компонентів професійної компетентності лікаря, визначенні організаційно-педагогічних умов їх формування.
The Problems of the Global Educational Environment and Their Solutions from the Perspective of Islamic Education
Authors: Rozi Bahru
Published: January 2025

Every child born into this world is in a state of fitrah (natural purity). However, this innate purity can undergo changes due to the influence of the environment in which they live and grow. This study aims to (1) understand the extent of environmental influence on the development of students, and (2) identify Islamic solutions for addressing global educational environmental issues. The method used in this study is library research, focusing on the collection and analysis of data from various relevant literature. The findings indicate that: (1) Substantially, the environment has a significant influence on students, both directly and indirectly. The environment in question includes the family, school, and community environments. Together, these three environments shape the character, morals, and values upheld by the students. (2) Islam offers comprehensive solutions to address global educational environmental issues by promoting the creation of integrated education. This integrated education necessitates harmonious cooperation among the three educational environments: family, school, and community. By working together, these three environments can support each other in forming a generation that is not only intellectually intelligent but also morally and spiritually strong, in accordance with Islamic teachings.
The Relationship between Religion and Reason in the Context of Islamic Education Philosophy from the Perspective of Ibn Rushd and Ibn Taimiyah
Authors: Lalahwa Illa Fadhliya , Gunawan Agus , Muhajir Muhajir
Published: January 2025

This article examines the thoughts of prominent philosophers Ibnu Rushd and Ibnu Taymiyah in terms of the relationship between religion and reason in the context of Islamic educational philosophy from the perspective of Ibn Rushd and Ibn Taymiyah. The purpose of this article is to provide readers with an understanding of the relationship between religion and reason in the context of Islamic educational philosophy. This research method uses the library research method or library study. The conclusion that can be drawn from Ibn Rushd is that being busy with philosophy does not make faith and religion damaged. Because philosophy does not conflict with religion, while religion does not deny philosophy, in fact it recommends and calls for it, because religion commands research and contemplation of the universe. In general, philosophizing is nothing more than examining forms in terms of their indication of the existence of a Creator. Ibn Taimiyah emphasized that in principle revelation and reason cannot conflict with each other. And if it is forced, there will be a conflict between the two, the conflict that arises is the argument, namely about the status of qat'i zanni, not about its status as revelation and reason.
فعالية استخدام كتاب الإعراب في قواعد اللغة العربية لترقية مهارة القراءة لطلاب الفصل الثالث الإبتدائي
Authors: Baharun Segaf , Al-Farizi Abdul Qowi , Arisandi Yusuf
Published: January 2025

Good reading results from understanding speech or paying attention to something heard, which is a condition for protecting a person from many mistakes. This study aims to determine how to teach reading skills using Arabic grammar parsing books to third-year construction students at the Dar es Salaam Institute, Malang and the effectiveness of using Arabic grammar parsing books to improve the reading skills of third-year elementary school students at the Dar es Salaam Institute, Malang. The method of this experimental research is using pre- and post-tests for the control group and the experimental group. The approach used is the quantitative approach. The tools for collecting data in this research are: observation, interview, and test. The results of the research indicate the T score calculated in this research (3.54) is greater than the T score in the table at the 5% level (2.06) and the T score in the table at the 1% level (2.80). We know that the previous hypothesis is acceptable, and this indicates that using the book on parsing Arabic grammar in teaching the Arabic language to teach reading skills is effective. 2) Using the book on parsing in Arabic grammar makes students feel enthusiastic and easy to improve their reading skill and find ease in determining the parsing in sentences. In conclusion, the use of the Arabic grammar parsing book in teaching the Arabic language to teach reading skills to third-year primary school students at the Dar es Salaam Malang Institute is effective in the effectiveness and development of students’ desire and motivation to improve reading skills.
Pelatihan Menulis Essai Bagi Santri di Pondok Pesantren Taqwimul Ummah Jemur Ngawinan Wonocolo Surabaya
Authors: Djuaini Achmad , Arisandi Yusuf
Published: January 2025

Santri are a group of people who live in Islamic boarding schools to learn the Koran. In the contemporary era, students can develop themselves by studying various sciences, including the world of writing. However, the reality shows that students at the Taqwimul Ummah Islamic Boarding School are involved in learning to write and only recite the Koran. The aim of this training is to equip students to have writing skills. This event presents trainers who are competent in essay writing. The activity is carried out in the form of a briefing and is immediately followed by essay writing practice. The provision consists of delivering material that introduces essay writing, the structure of essay writing, and the steps for writing an essay. Then the students receive an assignment to write an essay, which is submitted. Essay writing from students selected from the best works to be awarded.
Pendampingan Pola Hidup Bersih Santri Putri Darullughah Wadda’wah Pasuruan
Authors: Zunaida Laily , Abidin Zainal
Published: January 2025

Darullughah Wadda'wah Islamic Boarding School has health problems that are more or less the same as most Islamic boarding schools. Apart from environmental conditions, another determining factor is the students' habit of always living cleanly. Clean living education among santri is something that is considered difficult for the santri themselves. Apart from having to compete with school time and religious activities, they are required to be able to manage their own rooms. It becomes a very dilemma, when a student who has the habit of keeping his room clean and tidy because the student is already accustomed to a clean and healthy lifestyle, but ends up being influenced by other students who don't care about cleanliness and neatness. Apart from that, the efforts of students who have clean behavior to remind each other will be in vain when students who behave less in maintaining cleanliness consider this to be a thing of the past because they never correct their bad habits and tend to do whatever they want.
Pendampingan Literasi Digital dan Pengembangan Potensi Diri “Produktif di Dunia Digital”
Authors: Ibad M. Nashoihul
Published: January 2025

This service activity aims to improve digital literacy and develop students' self-potential at MA Ma'arif Pasuruan. Digital literacy is an essential skill in today's digital era, but related learning is still not effectively applied in the Madrasah Aliyah environment. Through this program, assistance is provided to students to arouse enthusiasm to continue to the lecture level and deepen their understanding of digital literacy. The methods used include mentoring, material presentation, training, and discussion. The results of this activity show that students can acquire new skills that can be applied in daily life, strengthening their potential to be more productive in the digital world.
Pelatihan Pengolahan Keripik Singkong untuk Pemberdayaan Ekonomi Masyarakat Desa Jati
Authors: Hikmawati Hanifah , Sulastri Sulastri
Published: January 2025

This training aims to empower the Jati Village community by increasing skills in processing cassava into cassava chips, with the hope of encouraging local economic growth and creating jobs. This training program includes theoretical and practical sessions on cassava processing techniques, product innovation, as well as marketing and business management strategies. The results of the training showed a significant increase in participants' skills, including the ability to select quality raw materials, processing and packaging of cassava chips. Participants reported increased income and success in starting new businesses, which have created additional jobs in the village.  This training was successful in achieving the goals of economic empowerment and improving community welfare, however additional follow-up and support is needed to ensure long-term business sustainability and development.
Peran Kuliah Kerja Nyata sebagai Wujud Pengabdian kepada Masyarakat di Universitas Islam Internasional Darullughah Wadda’wah Pasuruan
Authors: Juharoh Juharoh
Published: January 2025

The Community Service Program (KKN) is an implementation of the Tri Dharma of Higher Education, encompassing community service, teaching, and research. This study was conducted at Darullughah Wadda’wah Islamic Boarding School in Pasuruan, during the post-Covid-19 pandemic, focusing on the flagship program "Estafet Mufrodat." This program aimed to enhance the Arabic language skills of female students (santriwati), who are required to speak Arabic in their daily lives at the boarding school. The 2023 KKN was conducted entirely within the boarding school complex, emphasizing the empowerment of santriwati through language activities. The research methodology included problem identification through interviews, program planning in collaboration with the boarding school management, implementation, evaluation, and program sustainability. The results indicate that the Estafet Mufrodat program successfully improved the Arabic language proficiency of santriwati, created an enjoyable learning environment, and supported the implementation of the Tri Dharma of Higher Education. In conclusion, despite challenges due to the pandemic, KKN remained effective as a means of community service and the development of students' abilities in the context of community empowerment.
Planning of Supervision of Madrasah Principals on the Performance of Educational Personnel in Madrasahs
Authors: Ramdhani Deden , Robbi Mochammad Maulana
Published: January 2025

Education is a vital component in the development of a nation, and the quality of education is greatly influenced by the management of human resources for education personnel. To improve the professionalism of education personnel, human resource management in education needs to be improved and monitored regularly. This study aims to analyze the planning and implementation of the madrasah principal's supervision, with the goal of improving the performance of education personnel at MTsN 1 Pasuruan. The research method used is a case study with a qualitative approach. Data collection techniques include observation, interviews, documentation, and triangulation, while data analysis is carried out through data reduction, data presentation, and drawing conclusions. The results of the study indicate that the planning of supervision by the madrasah principal follows the stages that have been set out in the supervision book, such as background and legal basis, results of previous year's supervision, setting targets and schedules, selecting appropriate approaches, techniques, and models, and selecting supervision instruments. In its implementation, supervision is carried out in a family manner, which allows education personnel to feel appreciated and actively involved in the education process without feeling forced. The contribution of this study shows that effective supervision can improve the performance and professionalism of educational staff, which in turn improves the quality of educational services in institutions. Fulfillment of educational staff competencies is an important factor in achieving these goals.
Efektivitas Aplikasi Sistem Informasi Sumberdaya Terintegrasi Terhadap Pembayaran UKT Mahasiswa
Authors: Karimah Nadzirotul , Nikmah Tiara Iftitahun , Yulianti Dwi Rizfiya , Haerani Alfara , Hidayat Rofiq
Published: January 2025

This research aims to identify and analyze how effective the sister application is in paying UKT for UIN KHAS Jember students. This research uses quantitative research methods and comparative causal research. Data collection was obtained from an online questionnaire, which was distributed to 30 students of the Islamic Education Management (MPI) study program at UIN KHAS Jember. The sample was selected using a simple random sampling method. The results of data analysis show that the items in the questionnaire are valid and reliable. The classical assumption test shows that there are no problems of normality, heteroscedasticity and multicollinearity. Hypothesis testing through simple linear regression shows that the sister application has a significant and positive effect on UKT payments for UIN KHAS Jember students. Based on the results of this analysis, it was concluded that the sister application was effectively used for paying UKT for UIN KHAS Jember students.
MENUJU KELUARGA SAKINAH DENGAN BERSIWAK
Authors: Zuhdi Muhammad
Published: January 2025

This study aims to explore how the use of siwak can contribute to creating a sakinah family, namely a family full of tranquility, peace, and affection. Using a qualitative approach with a descriptive method, this study involved 10 Muslim families who routinely use siwak in their daily lives. Data were collected through in-depth interviews, participant observation, and document analysis. The results of the study indicate that the use of siwak is not only beneficial for oral and dental health, but also has high religious value, which can strengthen spiritual and emotional bonds between family members. The habit of using siwak together creates valuable moments of togetherness, improves communication, and reduces stress in the family. Thus, siwak can be an effective way to support the achievement of a sakinah family. This study provides practical recommendations for Muslim families and religious institutions to promote the use of siwak as part of efforts to create harmonious and healthy families.
PERAN TIM PAAREDI (POLA ASUH ANAK DAN REMAJA DI ERA DIGITAL) DALAM PERSPEKTIF HUKUM ISLAM
Authors: Hariyadi Riski , Hasim Fuad , Yuliawati Tita , Putri Nerisma Eka
Published: January 2025

Family Welfare Empowerment (PKK) is a community organization that empowers women to participate in Indonesia's development. PKK has been regulated in Presidential Regulation No. 99/2017 on the Family Empowerment and Welfare Movement.  One of the PKK priority programs is parenting children and adolescents. PPK Rambah village, Tanah Tumbuh sub-district, Bungo district has a flagship program, namely Parenting Children and Youth in the Digital Age (PAAREDI). In Rambah village, there is a PAAREDI structure consisting of the chairman, secretary, treasurer, membership field, socialization and communication field, education field, and talent and character field. The membership field is responsible for bookkeeping data on children aged 0-6 years, 7-12 years and 13-18 years.  The socialization field is in charge of arranging counseling schedules, finding resource persons, and sharing activities and materials on social media. The education sector is tasked with providing material on religion, pkbn, kdrt, pornography, hiv and the dangers of drugs. Then the field of talent and character is in charge of assisting children's interests and talents, as well as the formation of children's character in the family, fellow friends and society.  In Islam, the role of the PAAREDI team in Rambah Village is in line with the objectives of maqashid shari'ah, namely hifz din, hifz nafs, hifz 'aql, hifz nasl, and hifz mal.
A LEGAL ANALYSIS OF THE CILOK KAYI TRADITION IN MUKOMUKO
Authors: Nurjannah Revalysa Zovi , Jufrizal Jufrizal
Published: January 2025

This article discusses the ‘Urf Review of Cilok Kayi in Mukomuko Regency, Bengkulu This type of research uses a descriptive method with a qualitative approach so that it can find out directly the implementation of the tradition. While research data collection is carried out by means of observation, interviews and documentation obtained directly from sources related to the research, in this case the informants consist of religious leaders, traditional leaders, and some of the Mukomuko community. The research suggests that Cilok Kayi, a community tradition related to food or local customs, may not be considered ‘Urf fasid in Islamic law. However, if customary sanctions are imposed for non-observance, the tradition may be considered ‘Urf fasid, potentially violating the principles of freedom and justice. The study emphasizes the importance of considering the social, cultural, and religious context when assessing the legal status of a tradition in Islam, particularly in the case of ‘Urf fasid.
IMPLEMENTASI ISBAT NIKAH MASSAL DALAM PERSPEKTIF KOMPILASI HUKUM ISLAM
Authors: Kurniawan Achmad Alfan , Rahmadhani Aulia
Published: January 2025

Marriage, as stipulated by laws and regulations, requires documentation by an authorized official. Nonetheless, numerous marriages remain unregistered, as observed in Lampihong District, Balangan Regency, South Kalimantan, resulting in some individuals lacking a marriage certificate to validate their union. In response to this issue, KUA officials initiated mass marriage isbat to facilitate the issuance of marriage certificates. This study aims to elucidate the mass marriage isbat in Lampihong District and its relevance to the Compilation of Islamic Law (KHI). Employing an empirical legal research methodology with a case study approach and data were collected through interviews, the findings indicate that mass marriage isbat has been conducted in Lampihong District from 2019 to 2023, involving a total of 218 participants. This initiative aligns with Articles 5, 6, and 7 of the KHI. While these articles do not explicitly outline the procedure, the implementation of mass marriage isbat is deemed permissible and valid, as there are no prohibitions against its collective execution. Participants of the mass marriage isbat reported various advantages, particularly concerning the legitimacy of population administration, the safeguarding of marital rights and responsibilities, and the fulfillment of children’s needs.
LEGALITAS WARIS LINTAS RELIGI PERSPEKTIF YUSUF AL-QARAḌAWĪ DAN ‘ABD ALLĀH AḤMED AL-NA‘ĪM DITINJAU DARI MAQĀṢID SHARĪ‘AH IMAM AL-GHAZĀLĪ
Authors: Ramadheni Shaka Danendra , Sabri Fahruddin Ali
Published: January 2025

Raf‘ al-ḥaraj as an effort to remove hardship from a matter that is considered excessive for the soul, body, or property, either now or in the future. This study emphasizes to find the method of istinbāṭ, the foundation of legal istinbāṭ, and the analysis of the opinion of the legality of cross-religious inheritance of al-Qaraḍawī and al-Na'īm in the corridor of maqāṣid sharī‘ah of Imam al-Ghazālī. This research is a normative legal study with a library research approach to the book Fatwa-Fatwa Kontemporer volume 3 by Yusuf al-Qaraḍawī and the book Dekonstruksi Syari’ah: Wacana Kebebasan Sipil, HAM, dan Hubungan Internasional dalam Islam by ‘Abd Allāh Aḥmed al-Na‘īm. The study found that: first, al-Qaraḍawī uses the legal istinbāṭ approach of qiyās, maṣlaḥah mursalah, and the Hanafi school of thought on the interpretation of the connotation of kafir; while al-Na‘īm chooses to use reverse nasakh. Secondly, state policy and the social context of Muslim minorities influenced al-Qaraḍawī in issuing ijtihad on the legitimacy of inter-religious inheritance, while al-Na‘īm was motivated by the social context of his country and the death of his teacher, Mahmud Taha. In addition, it can be seen that in forming their opinions on the legitimacy of inter-religious inheritance, both figures strongly consider ḥifẓ al-dīn, ḥifẓ al-nafs, and ḥifẓ al-māl. This research is expected to contribute to offering a new perspective on Islamic law in the corridor of societal pluralism through maqāṣid sharī‘ah analysis.
TINDAKAN PENGHINAAN SEBAGAI ALASAN PEMAKZULAN WAKIL PRESIDEN TERPILIH PERSPEKTIF UUD 1945 DAN FIQH SIYASAH
Authors: Asrudi Asrudi , Rosalima Fahrica
Published: January 2025

One of the features of the presidential system is the process of presidential impeachment. The impeachment of the president is determined by a majority vote in the People's Consultative Assembly (MPR) proposed by members of the People's Representative Council (DPR) who have previously been tested in the Constitutional Court (MK) with reference to Article 7A of the 1945 Constitution as the reason for the impeachment of the President and/or Vice President. On the other hand, the elected Vice President for 2024 is indicated to have insulted several people over the ownership of the Fufufafa account on Kaskus. Therefore, this paper will explain how the impeachment process is carried out against the elected Vice President from the perspective of the 1945 Constitution and Fiqh Siyasah. The research method used in this paper is the literature study method. From the analysis conducted by the author, the process of impeaching the elected Vice President can be carried out if it is proven that they own the Fufufafa account based on the 1945 Constitution and Fiqh Siyasah. Thus, the results of this research can also help enhance understanding and knowledge about the mechanism of impeachment against the elected Vice President if proven to violate the provisions from the perspective of the 1945 Constitution and Fiqh Siyasah.
Impact of a Quality Cardiopulmonary Resuscitation Coach on Pediatric Intensive Care Unit Resuscitation Teams
Authors: McDermott Katie L. , Rajzer-Wakeham Kari L. , Andres Jennifer M. , Yan Ke , Liegl Melodee A. , Schindler Christine A.
Published: January 2025

Background

The quality cardiopulmonary resuscitation (CPR) coach role was developed for hospital-based resuscitation teams. This supplementary team member (CPR coach) provides real-time, verbal feedback on chest compression quality to compressors during a cardiac arrest.

Objectives

To evaluate the impact of a quality CPR coach training intervention on resuscitation teams, including presence of coaches on teams and physiologic metrics of quality CPR delivery in real compression events.

Methods

The quality CPR coach curriculum and role implementation were designed and evaluated using a logic model framework. Medical records of patients who had in-unit cardiopulmonary arrests were reviewed retrospectively. Data included physiologic metrics of quality CPR delivery. Analysis included descriptive statistics and comparison of arrest data before and after the intervention.

Results

A total of 79 cardiopulmonary arrests were analyzed: 40 before and 39 after the intervention. Presence of a quality CPR coach on resuscitation teams was more frequent after training, increasing from 35% before the intervention to 72% after (P = .002). No significant difference was found in the frequency of application of Zoll defibrillator pads. Metrics of quality CPR delivery and adherence with American Heart Association recommendations were either unchanged or improved after the intervention.

Conclusions

The quality CPR coach training intervention significantly increased coach presence on code teams, which was associated with clinically significant improvements in some metrics of quality CPR delivery in real cardiopulmonary arrests.
Potential of the Locally Produced Lactobacillus Inoculants in Ensiling Guinea Grass (Megathyrsus maximus) Forage
Authors: Devindi K. M. , Karunadhipathi U. L. , Priyantha R. , Liyanagunawardhana N. , Weerasinghe W. M. P. B. , Rajapaksha R. G. S. C. , Kumara M. B. P. Mahipala
Published: January 2025

Lactic acid bacteria inoculants are employed to accelerate forage ensiling ensuring silage quality. Inoculants for ensiling are not produced locally and are restricted for importation in Sri Lanka. This study evaluated the potential of locally produced, freeze-dried Lactobacillus inoculants containing Lactobacillus plantarum, Lactobacillus rhamnosus , and Lactobacillus oris, on ensiling of guinea grass (Megathyrsus maximus) forage. The experiment was conducted as a complete randomized design (CRD). Guinea grass forage harvested at the 10 % flowering stage were chopped and inoculated with each Lactobacillus (i.e. treatments ) species (i.e. 106 CFU/g fresh forage) or sprayed with deionized water (i.e. control). Six laboratory silos were prepared with each inoculant and one silo was the control. Silage samples were taken from 3 silos opened at 2 weeks and from the remaining 3 silos at 52 weeks post-ensiling. All samples were assessed for pH value and lactic acid content. In addition, the samples taken at 52 weeks were analyzed for organic matter digestibility (OMD) and metabolizable energy (ME) content. Guinea grass ensiled with Lactobacillus exhibited significantly (P<0.05) high lactic acid content and low pH valu e compared to the control as early as 2 weeks ensiling. At 52 weeks, guinea grass inoculated with L. rhamnosus recorded, significantly (P<0.05) higher lactic acid content c ompared to that inoculated with L. plantarum. Nevertheless, at 52 weeks guinea grass ensiled with, both L. rhamnosus and L. oris recorded significantly lower (P<0.05) pH values than those inoculated with L. plantarum. Inoculation of guinea grass with Lactobacillus significantly (P<0.05) increased the OMD and ME content of silage. This study concluded that locally produced, freeze-dried L. rhamnosus, and L. oris inoculants have the potential to enhance the ensiling guinea grass.
PLASMACELL NEOPLASMS WITH SPREADING IN THE BLOOD AND TISSUES: EXTRAMEDULLARY MYELOMA DISEASE A RARE AGGRESSIVE FORM OF MULTIPLE MYELOMA (First of two parts)
Authors: Testa Ugo , Leone Giuseppe G.M.
Published: January 2025

Multiple myeloma is a disease related to the proliferation of malignant plasma cells; in the  large majority of patients the disease is confined at the level of bone marrow. However, in a  minority of patients the malignant plasma cells are localized also outside bone marrow, either    at the level of peripheral blood (plasma cell leukemia) or at the level of soft tissues (extramedullary multiple myeloma). These two rare forms of aggressive MM (ultrahigh-risk (uHR) MM as MM leading to death within 24-36 months) are both associated with some molecular features and with a limited response to current treatments.
Anti-mullerian hormone evaluates ovarian function in patients with non-transfusion-dependent thalassemia
Authors: Li Yan , Yang Kun , Zhou Yali , Cheng Shiwu
Published: January 2025

Objective:
This study analyzed anti-mullerian hormone (AMH) levels in patients with non-transfusion-dependent thalassemia (NTDT) to evaluate their ovarian function.
Bridging ancient wisdom and modern insights: Understanding cancer through the lens of Dooshivisha and environmental toxicology
Authors: Singh Vishal , Sangeeta T. , Muzzammel Mohamed
Published: January 2025

The concept of Dooshivisha in Ayurveda, which refers to the accumulation of latent toxins in the body over time, provides a valuable framework for understanding the onset of chronic diseases such as cancer. This idea aligns closely with modern scientific findings on how environmental toxins, such as pesticide residues and persistent organic pollutants, accumulate in the human body and contribute to long-term health issues. Research shows that exposure to carcinogenic chemicals, particularly in early life through breastfeeding, significantly increases cancer risk. Similarly, lifestyle factors such as smoking, poor diet, and physical inactivity exacerbate toxin accumulation by promoting oxidative stress and systemic inflammation, creating an environment conducive to cancer development. Modern studies also reveal that toxins, whether environmental or lifestyle-related, disrupt bodily functions in ways that mirror the Ayurvedic understanding of Dooshivisha. The symptoms described in Ayurvedic texts, such as liver dysfunction or fluid accumulation, resonate with modern clinical manifestations of cancer, further supporting the relevance of this ancient concept. Ultimately, integrating Ayurvedic insights with contemporary preventive strategies – such as reducing exposure to toxins, improving lifestyle habits, and promoting detoxification – can help mitigate the health risks associated with chronic diseases such as cancer.
Estimation of melanocytic count in different donor areas in non-segmental vitiligo before and after narrow band ultraviolet B phototherapy
Authors: Hussien Marwa F. , Bassiouny Dalia A. , El Maadawi Zeinab M. , Soliman Ahmed M. , Al-Boani Asmaa M. , El Zawahry Yasmin B.
Published: January 2025

Background

The gluteal region and thigh are common donor sites used during surgical treatment of stable nonsegmental vitiligo (NSV). The outcome of transplantation could be improved if the donor site has higher melanocyte density.

Aim

To compare the count of melanocytes in the gluteal region and thigh, and evaluate the impact of narrow band ultraviolet B (NB-UVB) phototherapy on the quantity of melanocytes in both areas.

Methods

In this study, 20 stable NSV patients and five controls were included. Before and after 18 sessions of NB-UVB, two 3 mm punch biopsies were obtained from the normal skin of the thigh and gluteal region. Melan A was used for immunohistochemically labeling, and a count of melanocytes was performed on each sample.

Results

Before NB-UVB therapy, there was no significant difference in the number of melanocytic cells in the gluteal region and thigh in NSV patients (P=0.777) or between cases and controls. In NSV cases, the melanocytic count increased significantly in the thigh and gluteal region (P=0.002 for both), with no difference observed between the two sites (P=0.430). In the gluteal region, there was a significant positive correlation between the total cumulative joules (P=0.025, r=0.511) and the percentage change of melanocytic count and skin phototype (P=0.001, r=0.677).

Conclusion

In NSV patients, the melanocytic count in the normal skin of the thigh and gluteal region is similar. Following NB-UVB, this count significantly increased in both sites similarly. Both sites are equally appopriate for harvesting donor tissue for surgery in NSV cases preferably after NB-UVB phototherapy.
Evaluation of sexual function in females with chronic hepatitis C virus and its correlation with medical parameters
Authors: Alashry Shereen E. , Youssef Youssef E. , Eletreby Shahera , Elabasiry Eman A. , Ismail Sherif R.
Published: January 2025

Background

Hepatitis C virus (HCV) infection has a high prevalence in Egypt. The sexual function of female patients with chronic HCV has not been adequately studied in Egypt, where discussion of sexual desires and function is considered unacceptable by many.

Objective

This study aims to assess sexual function in females with chronic HCV and clarifies its correlation with medical parameters.

Patients and methods

Participants of this study were 120 female patients with chronic HCV and 120 healthy female controls. The Arabic-validated version of the Female Sexual Function Index (FSFI) was used to assess the sexual function of the patients and controls.

Results

There was a significant decrease in all domains of the FSFI score (desire, excitement, lubrication, orgasm, satisfaction, and pain) in female patients with chronic HCV versus the control candidates. We found a significant correlation between FSFI domains and hemoglobin level, leucocytic and platelet counts. However, the correlation between FSFI domains and serum HCV RNA, alanine transaminase was statistically nonsignificant.

Conclusion

Being a worker, having HCV+ve partner, having an old aged partner, the presence of financial stress, and duration greater than 2 years since HCV diagnosis, all were associated with a significant increase in female sexual dysfunction in chronic hepatitis C patients.
Practical acne management for dermatologists: consensus from the Egyptian Society of Dermatology and Venereology
Authors: Zaid Moustafa A. , Bedair Nermeen Ibrahim , Nagaty Ahmed , Abd Allah Tarek N. , GadAllah Nehal , Hossam Dalia , El-Naby Hussein H. , El Anany Galal , Ragab Magdy , Hegazy Mohamed S. , Azzam Omar , Nada Hanan , Morsy Hanan , Farouk Ahmed , Sadek Ahmed
Published: January 2025

Background

Acne is a chronic condition with inflammatory and non-inflammatory elements and scarring sequelae. Both adolescent and adult onsets have psychosocial impact and can greatly impair the quality of life. Several scales were developed to classify the acne severity, and variable algorithms are currently implemented for treatment; no consensus was reached on grading or treatment

Objective

A group of Egyptian dermatologists held this consensus meeting to identify a grading system that is accepted by the majority as well as the most appropriate treatment for each stage.

Results

Consensus was reached on several choices for each of the acne type and each of severity type as well as on maintenance protocols.

Conclusion

Acne management varies according to several factors in the practice of Egyptian dermatologists.
Histological, immunohistochemical, and serological markers of lepra reactions in leprosy
Authors: Suneetha Sujai , Das Pankaj , Singh Gautam K. , Vasudevan Biju , Priya K. Lekshmi , Mannu Anand , Kumar Das Nikunja , Mukhida Sahjid
Published: January 2025

Lepra reactions or ‘reactions’ in leprosy are immunological phenomena with distinct immunopathogenesis resulting in characteristic clinical manifestations and often are precursors of neuritis and disability. The reactions seen in leprosy are type 1, type 2, or erythema nodosum leprosum reaction and Lucio phenomenon. When undiagnosed or with a delay in intervention, these acute events affecting nerves and other organs can cause irreversible deformities and disabilities. Much research is ongoing to identify definitive biomarkers to predict and diagnose leprosy reactions early, to arrest the immunopathogenesis, prevent the morbidity/disabilities associated with reactions, and improve quality of life. After a brief introduction to leprosy and its reactions, we discuss the advances in identifying biomarkers for leprosy reactions. The serological, histopathological, and genetic markers have been covered in respect of all the three lepra reactions. We have strived to correlate the findings with respect to biomarkers for reactions with clinical features, pathogenesis, and immune histopathology of reactions for a better understanding.
Cystic mycetoma: an unusual clinical presentation of madurella mycetomatis
Authors: Supekar Bhagyashree B. , Chopkar Apoorva D. , Chopkar Samruddhi N. , Mukhi Jayesh I. , Gajbhiye Sunita T.
Published: January 2025

Mycetoma is clinically diagnosed on the basis of triad as tumefaction, discharging sinuses, and grains. It may be eumycotic or actinomycetic. Cystic form of mycetoma without sinus formation is an extremely rare presentation. To the best of our knowledge, this is the first instance of cystic presentation of eumycetoma caused by Madurella mycetomatis in a 38 years old male from India.
How coronavirus disease 2019 vaccination affect the level of vitamin D in serum and hair?
Authors: Abdel-Wahab Hossam M. , Amin Lydia T. , Montaser Mahmoud H.A.
Published: January 2025

Background

The world has suffered from the coronavirus disease 2019 (COVID-19) pandemic because of its high mortality and morbidity, resulting in the emergence of a variety of vaccines. Serum levels of vitamin D are inversely correlated with the incidence and severity of COVID-19. Hair loss is one of the most frequent complaints of COVID-19 patients.

Objectives

This study aims to evaluate the impact of COVID-19 vaccination on vitamin D levels in hair and serum.

Patients and methods

This study was conducted on 80 participants, divided into four equal groups according to the received COVID-19 vaccine. Serum and hair samples were obtained to measure vitamin D levels before and after 1 week of first and second dose of vaccinesand history of hair loss was recorded.

Results

Significant lower vitamin D levels in both serum and hair were recorded after the first dose (P<0.001). After the second dose, serum vitamin D has significantly increased in all groups (P<0.05), except the Pfizer group (P=0.07). Meanwhile, hair vitamin D had a nonsignificant increase in all groups (P>0.05). Hair loss was a frequent complaint after the COVID-19 vaccination, especially with the AstraZeneca vaccine, and less noted with the Pfizer vaccine.

Conclusion

COVID-19 vaccines harm serum and hair vitamin D with the potential increase in hair loss.
Correlation of gallium-68 prostate-specific membrane antigen positron emission tomography – Computed tomography/magnetic resonance imaging with histopathology characteristics in carcinoma prostate patients undergoing radical prostatectomy
Authors: Pratik P Taur , Sakthivel Deerush Kannan , Madhav S Tiwari , Sandeep P Bafna , Ragavan Narasimhan
Published: January 2025

Introduction:

Gallium-68 prostate-specific membrane antigen positron emission tomography (68Ga-PSMA PET) is being increasingly used in patients with prostate cancer (PCa) for the staging and detection of lymph node (LN) metastases, despite a lack of prospective, validated evidence. We aimed to investigate the relationship between the PSMA PET findings (maximum standardized uptake [SUVmax] value) and the final histopathology results (Gleason Grade [GG], and LN positivity) in patients undergoing radical prostatectomy.

Methods:

This is a single centre, prospective, observational study of 63 consecutive eligible patients treated at a tertiary care centre in India. Patients underwent 68Ga-PSMA PET computed tomography with fusion magnetic resonance imaging for staging, followed by a Transrectal ultrasound guided prostate biopsy. All patients underwent robotic-assisted radical prostatectomy with extended pelvic LN dissection as per the standard protocol. Clinical parameters and SUVmax values were collected and analysed.

Results:

The median preoperative prostate specific antigen (PSA) was 15.0 ng/ml (interquartile range: 9.4–28.0). A statistically significant correlation was observed between the PSA values and the SUVmax uptake (P < 0.001). Additionally, there was a statistically significant correlation between the SUVmax of the prostatic lesion and the GG on the radical prostatectomy specimens (P = 0.025), and SUVmax of LN and LN involvement (P < 0.001). The sensitivity and specificity of the 68Ga-PSMA PET scan were 77.8% and 88.7%, respectively.

Conclusions:

SUVmax of the PCa lesion and the GG Group on the final histopathology correlates significantly. There is an increased SUV uptake in Gleason’s Score (GS) 8, 9 tumours as compared to GS 6 and 7.
Effect of inferior alveolar plus buccal nerve block on donor site morbidity at buccal mucosal graft harvest site: A double-blinded, randomized placebo-controlled trial
Authors: Tarigopula Vivek , Mandal Swarnendu , Rohith Gorrepati , Dheeroo Dheeraj Kumar , Das Manoj Kumar , Tripathy Sambit , Barik Kalandi , Nayak Prasant
Published: January 2025

Introduction:

Pain at the buccal mucosal graft (BMG) harvest site in the immediate postoperative period is common and delays resumption of oral intake. This study compares the time for resumption of pain-free solid and liquid diets and postoperative pain scores at harvest site following the administration of inferior-alveolar nerve-block plus buccal-nerve block (IANB + BNB) versus placebo. We hypothesize that the intervention could decrease pain and aid in early food intake.

Methods:

A single-center, placebo-controlled, double-blinded randomized-control trial was conducted from September 2022 to August 2023 (CTRI). All individuals > 18 years undergoing BMG harvest were included. Patients with contraindications for BMG harvest and diabetes were excluded. Furthermore, patients requiring additional lingual/labial graft, bilateral BMG, or a history of prior BMG harvest were also excluded. IANB + BNB was performed with a 10 ml mixture comprising lignocaine, bupivacaine, and dexamethasone, while normal saline was administered in the control group. Both groups received submucosal local anesthetic infiltration.

Results:

After randomization (n = 28 in each group), patients who received IANB + BNB had an early return to pain-free liquid (median 1 vs. 2 days; P ≤ 0.001) and solid diet (median 2 vs. 3 days; P = 0.001) 1 day quicker than those who received placebo. In the intervention arm, Visual Analog Scale scores at harvest site were lower from 2 to 48 h postoperatively, had reduced paracetamol requirement (median 7 g vs. 9 g; P = 0.001), and fewer necessitated opioids for breakthrough pain (14.4% vs. 53.3%; P = 0.002).

Conclusion:

Patients who received IANB + BNB resumed a pain-free diet in the postoperative period quicker, reported lower pain scores, and there were lesser postoperative analgesic requirements.
Clinical, pathological, and oncological outcomes in unclassified renal cell carcinoma compared to clear cell renal cell carcinoma
Authors: Sawczyn Guilherme , Brambilla Caio , Rodrigues Gilberto Jose , Pereira Maykon William Aparecido Pires , Cardili Leonardo , Carvalho Paulo Afonso de , Gallucci Fabio Pescarmona , Sarkis Álvaro Sadek , Nahas William Carlos , Cordeiro Mauricio Dener
Published: January 2025

Purpose:

This study aims to assess the impact of unclassified renal cell carcinoma (uRCC) on clinical, pathological, and oncological outcomes compared with clear cell renal cell carcinoma (ccRCC).

Materials and Methods:

We analyzed the data of 48 uRCC and 688 ccRCC cases, collected from a histopathological database at a single center from July 2011 to August 2019. uRCC cases were confirmed according to the 2016 World Health Organization classification. Baseline characteristics, clinical findings, and oncological outcomes were compared between the groups.

Results:

Patients with uRCC exhibited the same clinical symptoms as ccRCC patients, a higher prevalence of lymphadenopathy (31.2% vs. 15.8%, P < 0.01), and greater sarcomatoid/rhabdoid differentiation on histology (12.5% vs. 5%, P = 0.03) compared to ccRCC patients. Although there was no difference regarding overall metastasis at initial diagnosis, distant lymphadenopathy (16.7% vs. 7.8%, P = 0.04) and liver metastasis (8.9% vs. 2.8%, P = 0.04) were more common in the uRCC group. The two groups had similar high-grade (HG) frequency on histology (62.5% for uRCC vs. 53.7% for ccRCC, P = 0.23). The estimated recurrence-free survival at 48 months was 94.3% for uRCC, 92.5% for low-grade (LG) ccRCC (P = 0.91), and 66.5% for HG ccRCC (P < 0.01). The estimated overall survival at 48 months was 66.1% for uRCC, 87.4% for LG ccRCC (P = 0.75), and 63.4% for HG ccRCC (P < 0.01).

Conclusion:

Our study demonstrates that uRCC has significantly higher rates of lymphadenopathy, sarcomatoid differentiation, and liver metastasis compared to ccRCC. Despite these differences, uRCC presents with similar clinical symptoms and histological grade as ccRCC. Furthermore, uRCC exhibits a recurrence rate comparable to LG ccRCC and an overall survival rate similar to HG ccRCC.
Single-port robot-assisted pyeloplasty through supine anterior retroperitoneal access
Authors: Sobhani Sina , Hemal Sij
Published: January 2025

This video explores the technique of robot-assisted pyeloplasty using the Da-Vinci Single-Port robot through the supine anterior retroperitoneal access in a 28-year-old male with a right-sided ureteropelvic junction obstruction. The patient was placed in a supine position, with a 10°–20° elevation of the ipsilateral flank. Retroperitoneal access was obtained at the McBurney’s point for the placement of the port. The standardized steps of the Anderson–Hynes pyeloplasty technique were executed. Operative time was 120 min with 10 mL of blood loss. The patient was discharged on the same day without complications. At 4-months follow-up, on the renal scan, the right kidney showed stable function with improved drainage.
Association of retinal sensitivity with gestational hypertension and obesity
Authors: Nandi Debasmita , Majumdar Swati , Banerjee Prosenjit
Published: January 2025

Background:

Pregnancy-induced hypertensive disorders occur in about 5% to 8% of all pregnant women in the world and are associated with various pathological changes in the retina due to vasospasm which might have long-term effects on other vital organs too. These may cause changes in retinal sensitivity which can be measured by static automated perimetry. Obesity in pregnancy also carries the risk of development of hypertension (HTN) and, therefore, various complications in both the mother and fetus.

Aim:

The aim is to study and compare retinal sensitivity by static automated perimetry in pregnant females with HTN and/or obesity.

Setting and Design:

This was a prospective cross-sectional study in a tertiary care center.

Materials and Methods:

Fifty pregnant females with HTN and/or obesity as cases and 54 as controls underwent systemic and ocular examination including retinal sensitivity measurement at 20 and 32 weeks of gestation.

Statistical Analysis:

Statistical software SPSS version 22 was used.

Results:

A significant decrease in mean retinal sensitivity (−7.71 ± 3.67 decibels, P < 0.001) and foveal sensitivity was observed in cases at 32 weeks of gestation compared to controls. With a 5 mmHg increase in systolic blood pressure, retinal sensitivity decreased by 0.795 decibels.

Conclusion:

Gestational HTN was associated with decreased retinal sensitivity compared to normal pregnant females without any observable retinal changes. Noninvasive investigation such as automated perimetry thus can provide us with valuable information regarding vascular changes in the retina which can involve other vital organs including placental circulation at the same time.