bluuebunny/crossref_metadata_2025 huggingface dataset:
What matters in development and sustainment of community dementia friendly initiatives and why? A realist multiple case study
Authors: Thijssen Marjolein , Kuijer-Siebelink Wietske , Lexis Monique A.S. , Sanden Maria W.G. Nijhuis-van der , Daniels Ramon , Graff Maud
Published: June 2022

Background
Dementia friendly communities (DFCs) are seen as key to participation of people with dementia and carers. Dementia-friendly initiatives (DFI) are important building blocks for the growth of DFCs. Therefore, it is essential to understand how DFIs are developed and sustained to secure the growth of DFCs. This study identifies contextual factors and mechanisms that influence the development and sustainment of Dutch DFIs. It also explains how these contextual factors and mechanisms are interrelated and the outcomes to which they lead.
Methods
Mixed methods, namely interviews, observations, documentation and focus groups, were used for this realist multiple case study. Participants were professionals (n = 46), volunteers (n = 20), people with dementia (n = 1) and carers (n = 2) who were involved in development and sustainment of DFIs in four Dutch DFCs.
Results
This study revealed three middle-range program theories as final outcomes: development of a support base, collaboration, and participation in DFIs by people with dementia and carers. These theories address institutional, organisational, interpersonal and individual levels in the community that are essential in development and sustainment of DFIs.
Conclusions
The development and sustainment of DFIs requires the development of a support base, collaboration, and participation in DFIs by people with dementia and their carers.
Autologous hematopoietic stem cell transplantation activity for lymphoma and multiple myeloma in China
Authors: Zhu Jun , Liu Weiping , Ji Jie , Zou Dehui , Cao Yang , Xu Yajing , zhou jian , Gao Sujun , Wang Fengr-Rong , CHEN WEN , Du Juan , Zhou Hui , Zhou Fuling , Shi Jimin , Zhang Xi , Yang Jianmin , Jing Hongmei , Jiang Zhongxing , Liu Hui , Li Caixia , Peng Hongling , Jiang Songfu , Wei Xiaolei , He Pengcheng , Liu Yao , Yang Haiyan , Li Zeng-jun , Huang xiaobing , Liu Lin , Shen Lijing , Liu Chuanfang , Song Yuqin , Qiu Lugui , Wang Xiaopei , Ma Jun
Published: June 2022

Little is known regarding the utilization rate of autologous hematopoietic stem cell transplantation (AHSCT) for lymphoma and multiple myeloma (MM) in the mainland of China. In 2019, the autologous stem cell transplantation group of Chinese Society of Clinical Oncology reported 4556 first transplantations with a utilization rate of 3.8% for lymphoma and MM. The AHSCT utilization rates were 2.4% for lymphoma and 11.3% for MM. For lymphoma, the transplantation utilization rate was over 5.0% in the age group of 20–50 years with a peak of 6.5% in the age group of 40–44 years; for MM, the rate was over 10.0% in the age group of 35–65 with a peak of 33.8% in the age group of 45–49 years. The eastern region had higher transplantation utilization rate than central and western regions (4.6% vs. 3.0% vs. 3.3%). There was a wide gap in AHSCT utilization rates between the developed and developing provinces. Beijing had the highest transplantation utilization rate for both lymphoma and MM. This study provided a comprehensive evaluation of AHSCT utilization for lymphoma and MM in China, which will be useful for policy-making with respect to healthcare resource allocation and disease control strategies.
A Systematic Assessment on Computation Offloading Mechanism in Mobile Edge Computing (MEC) --Manuscript Draft—
Authors: Sharma Aarti , Diwaker Chander
Published: June 2022

Mobile Edge Computing (MEC) is the application of cloud computing that is used to provide cloud services and advanced mobile applications to mobile users. The requirement of mobile users increases continually for accessing modern applications and cloud services at very high data speed and with less delay on their mobile devices. As the rate of demand increases for accessing applications and services by mobile users then it may increase the delay during transmission also data rate for accessing resources is decreasing. To handle these kinds of hazards, edge computing provides a computation offloading paradigm in which local edge servers are used to process user requests locally so that the data rate for accessing services and using modern mobile applications increases whereas the delay of accessing services from clouds also decrease as the services and applications are accessed locally by mobile users through local edge core network. In this paper, an attempt has been made to present offloading mechanism and its impact on MEC. The offloading can be categorized into three main categories such as decision-making regarding the offloading of computations, distributing computing resources within MECs, and management of mobility The paper presents an assessment of various offloading techniques with various parameters such as energy consumption, delay, execution time and system utility. The result depicts that in partial offloading the energy consumption, delay, and execution time are less and the system utility is more in perspective of other offloading techniques Furthermore, we present future direction and research challenges in MEC.
A Global Survey on the Utilization of Cryotherapy and Compression Therapy for the Prevention of Chemotherapy-Induced Peripheral Neuropathy
Authors: Chan Alexandre , Elsayed Amna , Ng Ding Quan , Ruddy Kathryn , Loprinzi Charles , Lustberg Maryam
Published: June 2022

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a serious side effect that is highly prevalent among cancer patients undergoing chemotherapy. There is a growing use of cryotherapy (CryTx) and compression therapy (ComTx) to prevent CIPN at cancer centers worldwide. In this study, we examined the awareness and recommendation of these modalities and evaluated factors associated with awareness. In addition, we investigated the type of technology utilized, barriers to implementation, and perceived adverse events of CryTx and ComTx.Methods: Active members of the Multinational Association of Supportive Care of Cancer (MASCC) were invited to complete an electronic survey that was sent via SurveyMonkey between September to October 2021. The survey assessed participants’ awareness, recommendation, usage, barriers to utilization, and perceived adverse events of CryTx and ComTx. Descriptive statistics and multiple logistic regression were utilized to analyze findings.Results: Out of 184 participants, 70.1% were physicians, 73.4% had over 10 years of practice, and 49.5% were practicing in an outpatient setting. While more than half (63.3%) of participants indicated awareness of CryTx for taxane-induced peripheral neuropathy, less than a quarter (22.8%) indicated recommendation in their practice setting. Factors associated with higher awareness of CryTx for patients receiving taxanes include living in Europe (OR=2.69, 95% CI [1.28-5.64], p=0.009), not practicing in an inpatient setting (OR=3.15, 95% CI [1.45-6.85], p=0.004), and self-identifying as non-physician (OR=2.40, 95% CI [1.03-4.37], p=0.041). Commercial cooling (31.5%) and compression (16.8%) gloves and socks were the most used modalities for CryTx and ComTx, respectively. The most identified barriers to CryTx and ComTx utilization include insufficient evidence (53.5%), logistics (34.8%), and patient discomfort (23.4%). Redness/irritation of skin (27.7%) and numbness/tingling (24.5%) accounted for about half of the perceived adverse events associated with use of CryTx and ComTx. Conclusion: Results of our global survey illustrated that there are varying modes in the delivery of CryTx and ComTx among cancer centers around the world. Education of the utilization of CryTx and ComTx, in addition to efficacy and implementation studies, are needed to close the gap between awareness and implementation in clinical practice.
General practitioner care in nursing homes during the first wave of the COVID-19 pandemic in Germany: A retrospective survey among nursing home managers
Authors: Kühl Anja , Hering Christian , Herrmann Wolfram , Gangnus Annabell , Kohl Raphael , Steinhagen-Thiessen Elisabeth , Kuhlmey Adelheid , Gellert Paul
Published: June 2022

Background
Though evidence on the detrimental impact of the COVID-19 pandemic in nursing homes is vast, research focusing on general practitioners’ (GP) care during the pandemic in nursing homes is still scarce.
Methods
A retrospective online survey among 1,010 nursing home managers in Germany was conducted during the first wave of the COVID-19 pandemic between November 2020 and February 2021. Associations between perceived deficits in GP care (routine and acute visits) and both general and COVID-19-related characteristics of nursing homes were analysed using multiple logistic regression analyses.
Results
The majority of nursing home managers reported no deficits in GP care (routine visits, 84.3%; acute visits, 92.9%). Logistic regression analyses revealed that deficits in GP care (routine visits) were associated with visiting restrictions for GPs (p < .001) and nursing home size. Small nursing homes (1–50 residents) were more likely to report deficits in GP care (routine visits) compared to medium (51–100 residents; p = .05) and large nursing homes (> 100 residents; p < .05). Further, deficits in GP care (acute visits) were associated with dementia as a focus of care (p < .05) and the burden of insufficient testing for SARS-CoV-2 among residents (p < .05). Moreover, visiting restrictions for GPs were associated with dementia as the focus of care (p < .05) and the COVID-19 incidence at the state (Bundesstaat) level (p < .05). Finally, COVID-19 cases in nursing homes were associated with size of nursing homes (p < .01; p < .001), COVID-19-incidence on the state level (p < .05; p < .01) and the burden of insufficient testing capacities for SARS-CoV-2 among residents (p < .01).
Conclusion
We found structural factors associated with GP care deficits during the pandemic. New concepts for GP care should be implemented in pandemic preparedness plans to ensure high quality, consistent, and reliable GP care as well as effective infection prevention measures in nursing homes.
On the p-Renyi entropy power for nonlinear diffusion equations on Riemannian manifolds
Authors: Wang Yu-Zhao , Zhang Hui-Ting
Published: June 2022

In this paper, we use a new method to prove the concavity of $p$-R\'enyi entropy power for doubly nonlinear diffusion equations on compact Riemanian manifolds with nonnegative Ricci curvature based on an explicit variational formula via trace free tensors. Moreover, we obtain the NIW formula between $p$-Renyi entropy power, $p$-Fisher information and $W$-entropy for doubly nonlinear diffusion equations.
High mobility of isolated three-fold polar vertices by electric fields
Authors: Li Mingqiang , Yang Tiannan , Chen Pan , Wang Yongjun , Zhu Ruixue , Li Xiaomei , Shi Ruochen , Liu Heng-Jui , Huang Yen-Lin , Ma Xiumei , Zhang Jingmin , Bai Xuedong , Chen Long-Qing , Chu Ying-Hao , Gao Peng
Published: June 2022

Recently various topological polar structures have been discovered in oxide thin films. Despite the increasing evidence of their switchability under electrical or mechanical fields, the dynamic property of an isolated one, which is usually required for applications such as data storage, is still absent as they are always formed as arrays in thin films and evolve together due to strong interactions with their neighbors. Here, we show the controlled nucleation and high mobility of isolated three-fold vertices under an applied electric field. At PbTiO3/SrRuO3 interfaces, nanosized three-fold vertices are formed. A two-unit-cell thick SrTiO3 layer provides critical electrical boundary conditions for the formation of three-fold vertices. Utilizing the SrTiO3 layer and in situ TEM electrical testing system, we found isolated three-fold vertices can move a long distance along the interface under electric fields in a controllable and reversible manner. Microstructural evolution details of the nucleation and propagation of isolated three-fold vertices are further revealed by phase-field simulations. This work demonstrates the high mobility of isolated three-fold vertices, shedding light on the extraordinary dynamic properties of isolated topological polar structures.
On order isomorphisms intertwining semigroups for Dirichlet forms
Authors: Li Liping , Lin Hanlai
Published: June 2022

This paper is devoted to characterizing the so-called order isomorphisms intertwining the L2 -semigroups of two Dirichlet forms. We first show that every unitary order isomorphism intertwining semigroups is the composition of h-transformation and quasi-homeomorphism. In addition, under the absolute continuity condition on Dirichlet forms, every (not necessarily unitary) order isomorphism intertwining semigroups is the composition of h-transformation, quasi-homeomorphism, and multiplication by a certain step function.MSC Classification: 60J46 , 60J35 , 31C25
Morphological relationships between external auditory canal and vital structures of tympanic cavity
Authors: Ohira Shinya , Komori Manabu , Nakamura Mitsuto , Matsumura Kentaro , Osafune Hiroshi , Kajiwara Riko , Wada Kota
Published: June 2022

Purpose
We aimed to evaluate the morphology of the external auditory canal (EAC) using a three-dimensional (3D) reconstruction of computed tomography (CT) scans of the temporal bone to corroborate and predict important anatomical structures involved in middle ear surgery based on the EAC morphology.
Methods
Temporal bone CT from 62 patients (120 ears) was used to perform 3D reconstruction (maximum intensity projection), of which 32 patients (60 ears) had chronic otitis media and 30 patients (60 ears) had normal temporal bones. The anatomical morphology of the EAC, tympanic sinus, vertical portion of the facial nerve, and jugular bulb were measured, and the anatomical relationship between the EAC morphology and important structures of the middle ear was analyzed.
Results
In ears with chronic otitis media, the overhang of the inferior wall of the EAC was significantly more than that in normal ears, and the antero-posterior length of the bony tympanic ring was short. Furthermore, the tympanic sinus was shallow, and vertical portion of the facial nerve tended to run outward. The EAC morphology correlated with the tympanic sinus depth and outward orientation of the vertical portion of the facial nerve.
Conclusion
A severe overhang of the inferior wall of the EAC and short antero-posterior length of the bony tympanic ring indicates a higher possibility of a shallow tympanic sinus and an outward orientation of the vertical portion of the facial nerve. These findings aid in predicting the difficulty of tympanic sinus operation and reducing facial nerve damage risk during EAC excision.
Benchmark Assessment for Optimization Andacceleration Libraries in Deep Learning-Based Models
Authors: Liang Gongbo , Alsmadi Izzat , Xin Xin
Published: June 2022

Deep Learning (DL) models are widely used in machine learning due to their performance and abilityto deal with large datasets while producing high accuracy and performance metrics. The size ofsuch datasets and the complexity of DL models cause such models to be complex, consuming largeamount of resources and time to train. Many recent libraries and applications are introduced todeal with DL complexity and efficiency issues. Neural network-based models have utilized stateof the art optimization and acceleration libraries to scale up the size of training datasets and thenumber of parameters in the models themselves. In this paper, we evaluated one example, MicrosoftDeepSpeed library through classification tasks. DeepSpeed public sources reported classificationperformance metrics on the LeNet architecture. We extended this through evaluating the libraryon several modern neural network architectures, including convolutional neural networks (CNNs)and Vision Transformer (ViT). Results indicated that neural network models for imaging tasks areimproved through using the DeepSpeed library in general.
HuR-induced CDK2 translational enhancement aggravates oral tongue squamous carcinoma
Authors: duan Yangfang , wei Youchun , wang Yunxia
Published: June 2022

Background: Oral tongue squamous carcinoma(OTSC) is an extremely malignant tumor specifically characterized by CDK2-mediated cell cycle perturbation.However,the underlying mechanism is poorly understood. HuR,an ubiquitously expressed member of the embryonic lethal abnormal vision family, participated in various malignent cancer. Therefore, this study aimed to explore the relationship of HuR and CDK2 in OTSC. Materials and methods: SCC25 cell line was sellected in vitro assay for the impact of HuR knockdown on tumor proliferation or CDK2 expression. IHC or mRNA levels of HuR and CDK2 expression were evaluated in malignent or benign lession tissue. Student’s t-test is used for two-group comparisons, and the one-way ANOVA for multiple group comparisons.Results:HuR knockdown reduced SCC25 proliferation, led to cell cycle arrest and dampened the colony formation. Mechanismly, HuR promoted CDK2 translation through binding to 3’untranslated regions. The luciferase activity assay futher authenticated the ARE-mediated HuR regulation on CDK2. Moreover, IHC results indicated that HuR expression exhibited progessive increase in the cases of pathological grade, accompanied by more cytoplasm distribution.Clinal datas demonstrated that the higher expression of HuR and CDK2 indicated poor prognosis and both had positive correlation. Conclutions: our study provides a compelling role of HuR in controlling the progression of OTSC by regulating CDK2 dependent cell cycle. These findings may provide a new therapeutic target for OTSC.
Detailed functional results after bladder-preserving surgery and high-dose-rate brachytherapy in pediatric bladder/prostate rhabdomyosarcoma
Authors: Ellerkamp Verena , Schmidt Andreas , Warmann Steven W , Eckert Franziska , Schaefer Juergen , Paulsen Frank , Fuchs Joerg
Published: June 2022

Purpose: In pediatric bladder/prostate-rhabdomyosarcoma, the rate of bladder preservation after neoadjuvant chemotherapy is high, with an excellent oncological outcome. Information about functional urological long-term outcomes is rare.Methods: Data of all patients who had undergone bladder-preserving surgery with or without brachytherapy at our institution between 2009 and 2020 were analyzed retrospectively.Detailed urological function was assessed focusing on age-related continence, bladder capacity and urodynamic findings.Results: We identified 40 patients, median age at surgery of 27 months (range 9-191), and 32 patients additionally received postoperative high-dose-rate brachytherapy. The median follow-up was 32.5 months (range 6-125). The bladder capacity increased from median 66.7% (21.1-180) of expected bladder capacity related to age 3 months after surgery to 87.4% (58.1-181.8) 9 months after surgery. In the group of aged >6-year-old, continence was 94% (83% with brachytherapy, 100% without brachytherapy). Erectile function was normal in 92% (90 % with brachytherapy, 100% without brachytherapy). Bladder capacity was more than 65% expected bladder capacity related to age in 70% (60% with brachytherapy, 86% without brachytherapy). 65% of all patients need neither anticholinergic drugs nor low-dose antibiotics (63% with brachytherapy, 71% without brachytherapy).Conclusions: Bladder preservation with good functional outcome can be achieved in localized bladder/prostate-rhabdomyosarcoma. In selected cases, supportive brachytherapy additionally contributes to an improvement in the oncological outcome with calculable risks for bladder and erectile function. Careful urological aftercare should be a fixed priority after oncological follow-ups.
OBJECT FIELD OF CRISIS MANAGEMENT AT THE BANK
Authors: Sinyagovsky Yu.
Published: June 2022

The main reason for the increased attention of banking supervisors and domestic banks to crisis management is the constant growth in the level of external and internal threats of crisis phenomena and the significant scale of losses for the banking system and the country's economy in case of their realization. In order to increase the efficiency of mechanisms of bank crisis management, it is necessary to formalize the object field, for which anti-crisis tools will be developed in the future. This is due to the fact that crisis management should be aimed at adapting its objects to any changes in both the internal environment and the external system, an element of which is a bank, as changes in them can act as triggers of crisis phenomena. The article aims to develop theoretical and methodological principles of bank crisis management based on the formalization of its object field. The author conducted a systematic, logical, and comparative analysis and synthesis of the scientific literature to achieve this goal. Such methods and techniques of the theory of knowledge as analysis and synthesis, the establishment of cause-and-effect relations of processes and phenomena development were also used. In the article, the expediency of applying the business-model concept for the formalization of object field of bank crisis management is proved. The author systematizes the composition of the objective field with fundamental division into financial and operational components. The operational business model determines the internal and external relations that give the bank access to key resources and transforms these resources into banking products and services of value to key customers through effective sales channels and the organisation of the relationship with them. The bank's financial business model includes key financial parameters (balance sheet, financial performance, and risk level). The results formed the scientific basis for improving the bank crisis management mechanisms and operationalizing anti-crisis tools. Further research will consist of developing the system of target parameters of operational and financial components of the business model. These target parameters will form an analytical basis for responding to crises, considering their stage, and making it possible to promptly activate the anti-crisis tools.
Bycatch of marine mammals in the Northwest Atlantic during commercial fishery (based on literature materials and observations by the Polar branch of VNIRO in 2013-2020)
Authors: Mishin T. V.
Published: June 2022

This paper describes one of the most acute problem for both environmental companies and fisheries - bycatch of marine mammals caused by bioresource exploitation in the Northwest Atlantic (NWA). There is no doubt that fishing has some impact on marine mammals, but information on bycatch of marine mammals is needed to understand the extent of the impact of different fishing gears. The paper is based on data from reports of observers of the Polar branch of VNIRO from fishing vessels in the 3LMNO NAFO zone (Newfoundland Island), as well as literary materials. As a result of the analysis, it has been found that small species of marine mammals, such as gray, common, harp seals from the Phocidae family, common dolphin, short-finned pilot whale (Delphinidae family) as well as harbour porpoise from the Phocoenidae family are most often injured by various fishing gears. Toothed whales (sperm whale, bottlenose whale) are the least susceptible to bycatch. Among the baleen whales, humpback whale, northern right whale and minke whale are often the victims of fishing. Gillnets, trawl fishing, and longlines are the greatest threats to small marine mammal species, while baleen whales are most vulnerable to traps, usually to catch ten-legged crustaceans Decapoda. Analysis of the literature has shown that, in general, the stocks of most marine mammal species in the NWA, excluding the northern right whale, are in a stable condition. The manuscript considers measures aimed at reducing bycatch of marine mammals.
The role of rotifer in water quality improvement in a fishpond
Authors: Gerasimova T. N. , Sadchikov A. P.
Published: June 2022

Rotifers are common in fresh and brackish water bodies, in coastal areas of the seas, and can be an effective tool for analyzing the state of the environment. The ability of rotifers to adapt to unfavourable environmental conditions has been considered in the course of studying the species composition of rotifers in a fish pond near Moscow under the conditions of the supply of organic artificial food for fish and changes in the temperature regime of water. During the period of increased temperature of the water (21-25 °C) and decrease in the concentration of dissolved oxygen from the surface to the bottom layers of water from 3.8 to 0.2 mgO/L in early July, Asplanchna priodonta helvetica , Brachionus angularis angularis and Brachionus calyciflorus dominated in the pond (98-100 % of the abundance and 99-100 % of the biomass of rotifers). During the period of elevated temperatures, the turbidity indices in the upper layer (0.2-0.5 m) were an order of magnitude lower than those in the deeper layers of the reservoir. Bacteria and tiny particles served as food for rotifers. The temperature of 18-25 °C was favourable for the development of B. angularis angularis in the fish pond. At a temperature of 18 °C, its abundance reached 1,500 ind./L (70 % of the abundance of rotifers). In August, when the temperature of the water column decreased from 20 to 18 °C, the biomass of A. priodonta helvetica changed from 0.3 to 9.5 mg/L (99 % of the biomass of rotifers). Polyarthra vulgaris dominated among small rotifers. During the period of low temperatures, the biomass of rotifers increased to 20 mg/L; its basis was A. priodonta helvetica. Rotifers are able to adapt to conditions of high organic input in a wide range of temperatures and participate in the restoration of water quality in a fish pond.
Josephson junctions of topological nodal superconductors
Authors: Seshadri Ranjani , Khodas Maxim , Meidan Dganit
Published: June 2022

Transition metal dichalcogenides (TMDs) offer a unique platform to
study unconventional superconductivity, owing to the presence of strong
spin-orbit coupling and a remarkable stability to an in-plane magnetic
field. A recent study found that when an in-plane field applied to a
superconducting monolayer TMD is increased beyond the Pauli critical
limit, a quantum phase transition occurs into a topological nodal
superconducting phase which hosts Majorana flat bands. We study the
current-phase relation of this nodal superconductor in a Josephson
junction geometry. We find that the nodal superconductivity is
associated with an energy-phase relation that depends on the momentum
transverse to the current direction, with a
4\pi4π
periodicity in between pairs of nodal points. We interpret this response
as a result of a series of quantum phase transitions, driven by the
transverse momentum, which separate a trivial phase and two distinct
topologically non-trivial phases characterized by different winding
invariants. This analysis sheds light on the stability of the Majorana
flat bands to symmetry-breaking perturbations.
Recent Advances in Biological Active Sulfonamide based Hybrid
Compounds Part A: Two-Component Sulfonamide Hybrids
Authors: Ghomashi Reihane , Ghomashi Shakila , Aghaei Hamidreza , Massah Ahmad Reza
Published: June 2022

Sulfonamides constitute an important class of drugs, with many types of pharmacological agents possessing antibacterial, anti-carbonic anhydrase, anti-obesity, diuretic, hypoglycemic, antithyroid, antitumor, and anti-neuropathic pain activities. The sulfonamides have the general formula R-SO2NHR', in which the functional group is bound to an aromatic, heterocycle, aliphatic, and so on. The nature of the R and R' moiety is variable, starting with hydrogen and ranging to a variety of moieties incorporating organic compounds such as coumarin, isoxazole, tetrazole, pyrazole, pyrrole, and so many other pharmaceutical active scaffolds that lead to a considerable range of hybrids named as sulfonamide hybrids. Part A of this review presents the most recent advances in designing and developing two-component sulfonamide hybrids containing coumarin, indole, quinoline, isoquinoline, chalcone, pyrazole/pyrazoline, quinazoline, pyrimidine, thiazole, benzothiazole, and pyridine between 2015 and 2020. Specifically, the authors review the scientific reports on the synthesis and biological activity of this kind of hybrid agent.
Obesity, Hypertension, and Kidney Dysfunction: Mechanical Links
Authors: Öksüz Merve , Göbel Pınar
Published: June 2022

Obesity is a risk factor for many diseases, including cardiovascular disease (CVD),
gastrointestinal disorders, type 2 diabetes (T2DM), joint and muscle disorders, respiratory problems,
and psychological problems that can significantly affect daily life. Hypertension affects
more than a quarter of the adult population in developed countries, constituting an important
health problem. In addition, its pathogenesis is not yet fully understood. Although hypertension
is mostly seen in overweight and obese people, it is usually more difficult to control in obese
people. It is well known that obesity is associated with the activation of both the sympathetic
nervous system and the renin-angiotensin system, contributing to hypertension. Kidney dysfunction
caused by obesity is a potential risk factor for cardiometabolic diseases, but the underlying
mechanism remains unclear. The purpose of this review study is to investigate the mechanical
links between obesity, hypertension, and kidney dysfunction.
Preparation of Silver Decorated Reduced Graphene Oxide Nanohybrid
for Effective Photocatalytic Degradation of Indigo Carmine Dye
Authors: Shetty Mohana Kikkeri Narasimha , Nayak Saurav Ramesh , Rajitha Kamalon , Madhusudhana Ambale Murthy , Swamy Ningappa Kumara , Hegde Mahesh Bhaskar
Published: June 2022

Background:

Even though silver decorated reduced graphene oxide (Ag-rGO) shows maximum
absorptivity in the UV region, most of the research on the degradation of dyes using Ag-rGO is
in the visible region. Therefore the present work focused on the photocatalytic degradation of indigo
carmine (IC) dye in the presence of Ag-rGO as a catalyst by UV light irradiation.

Methods:

In this context, silver-decorated reduced graphene oxide hybrid material was fabricated and
explored its potential for the photocatalytic degradation of aqueous IC solution in the UV region. The
decoration of Ag nanoparticles on the surface of the rGO nanosheets is evidenced by TEM analysis.
The extent of mineralization of the dye was measured by estimating chemical oxygen demand (COD)
values before and after irradiation.

Results:

The synthesized Ag-rGO binary composites displayed excellent photocatalytic activity in 2
Χ 10-5 M IC concentration and 5mg catalyst loading. The optical absorption spectrum of Ag-rGO
showed that the energy band-gap was found to be 2.27 eV, which is significantly smaller compared to
the band-gap of GO. 5 mg of Ag-rGO was found to be an optimum quantity for the effective degradation
of IC dye. The degradation rate increases with the decrease in the concentration of the dye at alkaline
pH conditions. The photocatalytic efficiency was 92% for the second time.

Conclusion:

The impact of the enhanced reactive species generation was consistent with higher photocatalytic
dye degradation. The photocatalytic mechanism has been proposed and the hydroxyl radical
was found to be the reactive species responsible for the degradation of dye. The feasibility of reusing
the photocatalyst showed that the photocatalytic efficiency was very effective for the second time.
Medication Use and Clinical Outcomes by the Dutch Institute for Clinical Auditing Medicines Program: Quantitative Analysis
Authors: Ismail Rawa Kamaran , van Breeschoten Jesper , van der Flier Silvia , van Loosen Caspar , Pasmooij Anna Maria Gerdina , van Dartel Maaike , van den Eertwegh Alfons , de Boer Anthonius , Wouters Michel , Hilarius Doranne
Published: June 2022

Background

The Dutch Institute for Clinical Auditing (DICA) Medicines Program was set up in September 2018 to evaluate expensive medicine use in daily practice in terms of real-world effectiveness using only existing data sources.

Objective

The aim of this study is to describe the potential of the addition of declaration data to quality registries to provide participating centers with benchmark information about the use of medicines and outcomes among patients.

Methods

A total of 3 national population-based registries were linked to clinical and financial data from the hospital pharmacy, the Dutch diagnosis treatment combinations information system including in-hospital activities, and survival data from health care insurers. The first results of the real-world data (RWD) linkage are presented using descriptive statistics to assess patient, tumor, and treatment characteristics. Time-to-next-treatment (TTNT) and overall survival (OS) were estimated using the Kaplan-Meier method.

Results

A total of 21 Dutch hospitals participated in the DICA Medicines Program, which included 7412 patients with colorectal cancer, 1981 patients with metastasized colon cancer, 3860 patients with lung cancer, 1253 patients with metastasized breast cancer, and 7564 patients with rheumatic disease. The data were used for hospital benchmarking to gain insights into medication use in specific patient populations, treatment information, clinical outcomes, and costs. Detailed treatment information (duration and treatment steps) led to insights into differences between hospitals in daily clinical practices. Furthermore, exploratory analyses on clinical outcomes (TTNT and OS) were possible.

Conclusions

The DICA Medicines Program shows that it is possible to gather and link RWD about medicines to 4 disease-specific population-based registries. Since these RWD became available with minimal registration burden and effort for hospitals, this method can be explored in other population-based registries to evaluate real-world efficacy.
The impact of a digital artificial intelligence system on the monitoring and self-management of non-motor symptoms in People with Parkinson’s: Proposal for a Phase 1 implementation study (Preprint)
Authors: Meinert Edward , Milne-Ives Madison , Chaudhuri Kallol Ray , Harding Tracey , Whipps John , Whipps Sue , Carrol Camille
Published: June 2022

BACKGROUND

Non-motor symptoms of Parkinson’s disease are a major factor of disease burden but are often underreported in clinical appointments. A digital tool has been developed to support the monitoring and management of NMS.

OBJECTIVE

The aim of this study is to establish evidence of the impact of the system on patient confidence, knowledge, and skills for self-management of NMS, symptom burden, and quality of life of people with Parkinson’s (PwP) and their care partners (CPs). It will also evaluate the usability, acceptability, and potential for adoption of the system for PwP, CPs, and healthcare professionals (HCPs).

METHODS

A mixed-methods implementation and feasibility study based on the Non-adoption, Abandonment, Scale-up, Spread, and Sustainability framework will be conducted with 60 PwP-CP dyads and their associated HCPs. Participants will be recruited from outpatient clinics at the University Hospitals Plymouth NHS Trust’s Parkinson’s service. The primary outcome, patient activation, will be measured over the 12-month intervention period; secondary outcomes include the system’s impact on health and well-being outcomes, safety, usability, acceptability, engagement, and costs. Semi-structured interviews with a subset of participants will gather a more in-depth understanding of users' perspectives and experiences with the system. Repeated measures ANOVA will analyse change over time and thematic analysis will be conducted on qualitative data. The was peer-reviewed by the Parkinson’s UK Non-Drug Approaches grant board, and is pending HRA and REC ethical approval (IRAS reference number: 311333).

RESULTS

Results will be disseminated in academic peer-reviewed journals and in platforms and formats that are accessible to the general public, guided by patient and public collaborators.

CONCLUSIONS

The study's success criteria will be affirming evidence regarding the system's feasibility, usability and acceptability, no serious safety risks identified, and an observed positive impact on patient activation.

CLINICALTRIAL

ClinicalTrials.gov (NCT05414071)
Visit Types in Primary Care with Telehealth Use during COVID-19: Systematic Review (Preprint)
Authors: Ward Kanesha , Vagholkar Sanjyot , Sakur Fareeya , Khatri Neha Nafees , Lau Annie Y.S.
Published: June 2022

BACKGROUND

Telehealth was rapidly incorporated into primary care during COVID-19. However, there is limited evidence on which primary care visits had utilised Telehealth.

OBJECTIVE

The objective of the study was to conduct a systematic review to assess 1/ what visit types in primary care have been reported with use of Telehealth during COVID-19, 2/ for each visit type identified in primary care, under what circumstances Telehealth is suitable, and 3/ benefits and drawbacks reported using Telehealth in primary care during COVID-19.

METHODS

Systematic review using narrative synthesis. Studies were obtained from four databases (OVID (MEDLINE), CINAHL Complete, PDQ-Evidence, and ProQuest) and grey literature (NSW Health, RACGP, and WHO guidelines). Three independent reviewers screened studies featuring Telehealth use during COVID-19 in primary care. Levels of evidence were assessed according to Grading of Recommendations Assessment, Development and Evaluation (GRADE). Critical appraisal was conducted using Mixed Methods Appraisal Tool. Benefits and drawbacks of Telehealth were assessed according to the National Quality Forum Telehealth Framework. PROSPERO registration: CRD42022312202. PRISMA-compliant: See Appendix 1 for the completed checklist of preferred reporting items for systematic review and meta-analyses (PRISMA) guidelines.

RESULTS

Nineteen studies, predominately cross-sectional surveys/interviews (68%, 13/19), were included. Seven primary care visit types were identified: chronic condition management (89%, 17/19), existing patients (89%, 17/19), medication management (89%, 17/19), new patients (84%, 16/19), mental health/behavioural management (79%, 15/19), post-test results follow-up (74%, 14/19), and post-discharge follow-up (37%, 7/19). Benefits and drawbacks of Telehealth were reported across all visit types, with chronic condition management being one of the visits reporting the greatest use due to a pre-existing patient-provider relationship, established diagnosis, and lack of complex physical examinations. Both patients and clinicians reported benefits of Telehealth, including improved convenience, focused discussions, and continuity of care despite social distancing. Reported drawbacks include technical barriers, impersonal interactions, and semi-established reimbursement models.

CONCLUSIONS

Telehealth was used for different visit types during COVID-19 in primary care, with a majority for chronic condition management, existing patients, and medication management. Further research is required to validate our findings and explore the long-term impact of hybrid models of care for different visits in primary care.

CLINICALTRIAL
Electrical Hazards Risk Assessment of Cyber Security in Smart Grids
Authors: Malesvich Stephen
Published: June 2022

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BROTOCs and Quantum Information Scrambling at Finite Temperature
Authors: Anand Namit , Zanardi Paolo
Published: June 2022

Out-of-time-ordered correlators (OTOCs) have been extensively studied in recent years as a diagnostic of quantum information scrambling. In this paper, we study quantum information-theoretic aspects of the regularized finite-temperature OTOC. We introduce analytical results for the bipartite regularized OTOC (BROTOC): the regularized OTOC averaged over random unitaries supported over a bipartition. We show that the BROTOC has several interesting properties, for example, it quantifies the purity of the associated thermofield double state and the operator purity of the analytically continued time-evolution operator. At infinite-temperature, it reduces to one minus the operator entanglement of the time-evolution operator. In the zero-temperature limit and for nondegenerate Hamiltonians, the BROTOC probes the groundstate entanglement. By computing long-time averages, we show that the equilibration value of the BROTOC is intimately related to eigenstate entanglement. Finally, we numerically study the equilibration value of the BROTOC for various physically relevant Hamiltonian models and comment on its ability to distinguish integrable and chaotic dynamics.
Exploratory Research Opportunities Of Computing In Life Sciences
Authors: Dr.Vignesh Ramamoorthy H Guest Editor
Published: June 2022

Computers are employed in lifestyle science in a variety of ways, including the usage of sensors and other devices that only a laptop can comprehend, as well as computers' incredible ability to do complex studies fast. Information Science majors learn to collect, analyze and interpret many different information sources to understand our world. They study how we interact with all things digital, including software, devices and algorithms, and are able to create social and technological solutions that are truly engaging for those who use them, apply those solutions to real problems, and evaluate their effectiveness. Computational Life Sciences is quickly becoming one of the most important and exciting fields in all of science and generation. The intersection of modern biology, bioinformatics, genomics, big data analytics, quantitative mathematical modelling, information discovery and synthesis, text mining, computational bio-imaging, scientific sciences, molecular dynamics, and high-performance computing is known as computational life sciences. The complexity of biological structures necessitates this approach in order to comprehend the operation of regulatory networks and to go from remote qualitative descriptions to a more comprehensive understanding. The complexity of biological structures necessitates this method in order to comprehend the operation of regulatory networks and to go from qualitative descriptions to quantitative knowledge. Computational Life Sciences is having a significant influence on a variety of technologies, including biomarker development, treatment objectives, and drug discovery. As a result, one of the most important tasks for this study in the next years will be to extract relevant statistics from enormous amounts of data and to build larger computer models to examine the more difficult features.
UJI VALIDITAS DAN RELIABILITAS KUESIONER PERILAKU PROSOSIAL
Authors: Rosita Esi , Hidayat Wahyu , Yuliani Wiwin
Published: June 2022

Good prosocial behavior is important for students to support student success in both the social and academic fields.  The one of the measuring tools that can be used is a questionnaire.  The purpose of this research is to make a questionnaire along with the validity and reliability test of the questionnaire.  The research used is a R&D method with 13 respondents of class XI at SMK Aloer Wargakusumah. Based on the results of the research, it is known that the questionnaire test with 50 statement items shows that there are 36 valid statement items with a comparison between rcount> rtable.  While the reliability test shows the Cronbach Alpha value> 0.60, then the questionnaire can be said to be reliable or consistent with the moderate category according to Sugiyono's criteria table.  Keywords:  prosocial behavior,  questionnaire, validity and reliability test
Uji Cemaran Mikroba dan Kapang Khamir Ekstrak Air Daun Muntingia calabura L. (Kersen)
Authors: Rahmawati Aulia Nur , Saryanti Dwi , Nurita Sari Fryda , Yovita Turnip Irma
Published: June 2022

Kersen (Mutingia calabura L.) is a plant that can be used as a raw material for medicine because it has many medicinal benefits. Kersen as a medicinal raw material must pass a quality parameter testing process to be safe to use. One of the extract quality parameters is the total plate count for microbial (ALT) and yeast contamination (AKK). This study aims to evaluate the suitability of microbial and yeast contamination in the water extract of Kersen leaves to the applicable regulations. Extraction of Kersen leaves used maceration method with water solvent for 3 days with a ratio of 1:10. The results obtained from the water extract of Kersen leaves are organoleptically in the form of thick extract, dark brown in color, sour taste, bitter, and has a distinctive odor. The ALT value in the aqueous extract of cherry leaves was 8.4 x 10⁴ colonies/g. The AKK value in the aqueous extract of cherry leaves was 102 colonies/g which was reported as an approximate AKK value. The ALT and AKK values in the water extract of Kersen leaves meet the safety and quality requirements of traditional medicine.
Letramento crítico e questões de gênero e sexualidade em aulas de língua inglesa no Projeto Casas de Cultura no Campus: reflexão e expansão de percepções
Authors: França Lucas da Silva , Ifa Sérgio
Published: June 2022

É possível ensinar a língua inglesa e promover criticidade sobre alguns temas sociais urgentes? A investigação buscou responder a esse questionamento por meio de uma pesquisa-ação com alunos do nível pré-intermediário do projeto de extensão Casas de Cultura no Campus (CCC) da Universidade Federal de Alagoas (UFAL). Os resultados apontam que a criação de ambientes para o desenvolvimento da consciência crítica, os debates sobre os temas abordados (gênero e sexualidade) e as atividades trabalhadas em sala, desenvolvidas sob a perspectiva do Letramento Crítico (JANKS, 2013, 2014; MCLAUGHLIN & DEVOOGD, 2004), propiciaram reflexões, reconstruções e ampliação sobre os temas discutidos. Houve também um significativo desenvolvimento linguístico-discursivo dos alunos em língua inglesa. Os dados evidenciam, portanto, a relevância do ensino crítico aliado a um ensino de língua inglesa que leva em consideração os interesses e necessidades dos alunos para formação cidadã.
As Teorias da Argumentação na Língua e dos Blocos Semânticos: uma análise de gêneros textuais
Authors: De Moraes Gisele Benck , Cayser Elisane Regina
Published: June 2022

Este artigo tem como objetivo analisar dois gêneros textuais diferentes à luz da Teoria da Argumentação na Língua e da Teoria dos Blocos Semânticos. Para a fundamentação teórica foram utilizados estudos de Ducrot (1987, 1988, 2005), Carel (2002, 2005) e Kleiman (2005). Com base nesses estudos, partimos da hipótese de que estudar e trabalhar com textos de diferentes gêneros podem ajudar professores em sala de aula de língua materna a aprofundarem conhecimentos de compreensão e de escrita textual. Assim, foram analisados dois textos, um do gênero capa de revista e outro do gênero notícia, e os resultados apontam para as possibilidades argumentativas que os enunciados projetam dentro de um texto e as relações que são estabelecidas entre elas, de acordo com os encadeamentos argumentativos propostos pelas instruções enunciativas.