bluuebunny/crossref_metadata_2025 huggingface dataset:
Analyse critique d’images et production visuelle créative
Authors: MULLER Catherine
Published: April 2022

L'article interroge la façon dont la réception d'images médiatiques et la production de documents visuels permettent de développer chez les apprenants de langue une réflexivité et une attitude critique, entendues comme des compétences interculturelles. Le projet qui fait l'objet de l'analyse a été mis en œuvre dans des cours de français enseigné comme langue étrangère en contexte universitaire auprès d'un public en mobilité académique. Grâce au dispositif, les étudiants se sont interrogés sur les représentations véhiculées par les images introduites. Invités à élaborer à leur tour une affiche ou une vidéo remettant en cause des stéréotypes, ils se sont employés à lutter contre des clichés de diverses natures. La présentation de ces productions a également donné lieu à un positionnement critique au sein du groupe et à des négociations entre pairs.
L’interculturel au prisme d’une pédagogie de la réussite étudiante
Authors: ABOAB Deborah , ROLLINAT-LEVASSEUR Eve-marie , WOERLY Donatienne
Published: April 2022

Cet article propose l'analyse des représentations de l'interculturel perceptibles chez les étudiant.e.s et chez les enseignant.e.s telles qu'elles se révèlent dans la mise en place d'un dispositif de rencontres entre des groupes d'étudiants de FLE et d'étudiants de didactique du FLE. Nous montrons d'abord comment les étudiants peuvent sortir de l'identité moyenne qu'ils élaborent en réponse aux attentes qu'ils anticipent pour s'ouvrir à la complexité des échanges interculturels. Puis, nous étudions la façon dont l'enseignant.e peut prendre en compte les fragilités des étudiant.e.s, leurs contraintes et les rapports de force, linguistiques, culturels. Si la question de l'interculturel est au centre de l'enseignement du FLE et de celui de la didactique du FLE, le concept d'interculturalité ne rend pas compte de la totalité de ce qui est observable dans ces rencontres. En effet, dans ce dispositif, la confrontation à l'autre met en jeu de multiples paramètres, de multiples dimensions (sociales, d'expérience de vie, d'identités professionnelles, d'identités genrées, de personnalités avec leurs configurations psychologiques etc.). C'est pourquoi le travail d'atténuation, l'art du contrôle et de l'encadrement, voire l'autocensure peuvent être intériorisés et confondus avec les habiletés que les enseignant.e.s mettent en œuvre dans une formation à l'interculturel.
De la prise de conscience à une posture engagée
Authors: PUTSCHE Julia , FAUCOMPRÉ Chloé
Published: April 2022

Cette contribution s'intéresse à la formation des enseignant.e.s de la langue du voisin (français et allemand comme langues étrangères) dans la région transfrontalière du Rhin supérieur. Elle présente les tenants et aboutissants d'une recherche-action franco-allemande menée de 2014 à 2018, visant à faire prendre conscience aux futur.e.s enseignant.e.s de la langue du voisin du rôle à endosser en tant que médiateur interculturel transfrontalier dans un espace aussi particulier que le Rhin supérieur. Après avoir présenté les spécificités de notre région, qui font d'elle un contexte particulier d'enseignement et d'apprentissage des langues, cet article tâchera de mettre en exergue la plus-value d'un dispositif de type research-based-learning, afin de dépasser la prise de conscience des futur.e.s enseignant.e.s et d'aboutir à un réel engagement de leur part. Parallèlement à cela, notre contribution propose une réflexion sur le double engagement de cette recherche, qui se situe aussi bien au niveau de l'ingénierie pédagogique qu'au niveau de notre coopération scientifique binationale.
Shadow Economy and Political Participation in the United States
Authors: GOKCEKUS Omer , MCFALL Shawn M. , BAGIRZADEH Elshan
Published: April 2022

The empirical evidence presented in this study indicates a negative relationship between the size of the shadow economy and political participation. Based on panel data from 50 states for four election cycles between 2001 and 2008, regression results show that in the United States, both voter turnout rate and political contributions decline as the shadow economy grows. Specifically, when the size of the shadow economy increased across election cycles and between states by 1%, the voter turnout rate declined by 6.6% (P<0.01), and political contributions went down by 11.2% (P<0.01).
ASSESSMENT OF ORGANIZATIONAL AGILITY: ADAPTATION AND VALIDATION OF THE SCALE FOR APPLICATION IN TURKEY
Authors: Gurbuz Fatma Gulruh , Hatunoglu Sukru Baris
Published: April 2022

Purpose- Organizational agility is a critical dynamic capability necessary for organizations that compete in today’s rapidly changing business conditions. In the literature, there are multiple perspectives to draw the borders for an organization’s ability to be agile. Although Organizational Agility is a well-established concept in studies executed in U.S. and Europe, researches performed in Turkey still lack focus on agility dramatically. In order to fill this gap, this study is intended to adapt and validate the measurement scale of Lee, Sambamurthy, Lim and Wei (2015) to be used for companies operating in Turkey.
Methodology- Lee et al. (2015) formed a 12-item scale to measure the components of organizational agility which are “proactiveness”, “radicalness”, “responsiveness” and “adaptiveness”. Items to measure these components are translated into Turkish and reviewed for clarity, comprehensibility and risk of ambiguity by the linguistic professionals and academicians in the field. Finally, the scale is tested on a sample of 320 employees in managerial positions of companies that are operating in Turkey.
Findings- 12-item scale is tested through exploratory factor analysis to check for any differences in the items’ distribution between the components of the construct. Four factors are formed parallel to the original scale representing proactiveness, radicalness, responsiveness and adaptiveness. As a consequence of very close factor loadings under two different components, one item from the adaptiveness factor is removed. The reliability values of all factors were above the necessary thresholds in the literature. In order to confirm the results of the EFA, AMOS is used for the confirmatory factor analysis and the results showed a very high model fit. Subsequently, discriminant validity and convergent validity tests are executed showing satisfactory output with no errors.
Conclusion- The results show that the scale of Lee et al. (2015) can be used to measure the organizational agility of companies in Turkey. For their future studies, researchers can execute these scales on managerial level employees (since organization-wide information is required) to assess the levels of four dimensions of organizational agility.

Keywords: organizational agility, proactiveness, radicalness, responsiveness, adaptiveness
JEL Codes: M10, M16, M19
Высокоскоростная ВЭЖХ (краткий обзор)
Authors: Яшин Яков Иванович , Яшин Александр Яковлевич
Published: April 2022

В кратком обзоре обобщены и обсуждены основные вопросы высокоскоростной жидкостной хроматографии, в частности, основные способы сокращения времени разделения: ультра-ВЭЖХ, хроматография на поверхностно-пористых сорбентах, высокотемпературная хроматография, хроматография на монолитных колонках. Во всех этих способах пути внешней и внутренней диффузии сокращаются различными способами, что ускоряет массообмен и позволяет использовать высокие скорости элюирования. Экспресс-методы используются в различных методах ВЭЖХ: обращенно-фазовый, капиллярный, поликапиллярный, гидрофильный, хиральный, противоточный, аффинный. Высокоскоростная жидкостная хроматография широко используется в фармакокинетике, для анализа лекарственных средств в фармацевтике, при промышленном анализе быстрых процессов, для анализа качества и безопасности пищевых продуктов и напитков, для контроля загрязняющих веществ в окружающей среде. Данный вид хроматографии используется для разделения сложных многокомпонентных смесей: катехинов, теафлавинов в чае, хлорогеновых кислот в кофе, полифенолов и флавоноидов в овощах, фруктах и ягодах, стероидов, белков и жирных кислот в биологических жидкостях. Для детектирования в высокоскоростной жидкостной хроматографии используются наиболее распространенные системы детектирования: масс-спектрометрическая, диодно-матричная, ультрафиолетовая, светорассеивающая, флуоресцентная и другие. Экстракцию исследуемых соединений проводили как традиционными методами (твердофазный и жидкостно-жидкостный), так и микроволновой и жидкостной экстракцией при высоких давлениях. Высокоскоростная жидкостная хроматография используется для исследования взаимодействия лекарственного средства с белком, определения активных соединений в таблетках и определения компонентов запаха. Высокоскоростная жидкостная хроматография, несомненно, расширяет аналитические возможности высокоэффективной жидкостной хроматографии в различных жизненно важных областях, способствуя прогрессу высокоэффективной жидкостной хроматографии. Для сверхбыстрой высокоэффективной жидкостной хроматографии необходима быстрая электроника в жидкостных хроматографах, некоторые компании начали разрабатывать такую электронику.
Адсорбция метана на графеновом аэрогеле
Authors: Меметова Анастасия Евгеньевна , Нескоромная Елена Анатольевна , Зеленин Андрей Дмитриевич , Бабкин Александр Викторович , Меметов Нариман Рустемович , Герасимова Алена Владимировна
Published: April 2022

Статья посвящена изучению адсорбции метана на графеновом аэрогеле в широком интервале давлений при температурах выше критической. В работе синтезирован углеродный наноструктурный материал, представляющий собой аэрогель на основе восстановленного оксида графена с применением сверхкритических методов обработки гидрогеля в среде изопропилового спирта. Полученный адсорбент обладает хорошо развитой пористой структурой (S(БЭТ)=657 м2/г; V(DFT)=0.766 см3/г), что создает хорошие перспективы его использования для адсорбции энергетически важных газов, в частности, метана. Благоприятным фактором для увеличения скорости адсорбции-десорбции в таких системах является большой объем мезопор с диаметрами ~5.0 нм.

Изучена адсорбция метана на полученном графеновом аэрогеле при температурах 298.15, 303.15, 313.15 К и давлении до 100 бар. Максимальная величина адсорбции составила 7.31 ммоль/г при 100 бар и 298.15 К. Представлены результаты расчетов адсорбции метана на графеновом аэрогеле в области сверхкритических температур по теории объемного заполнения микропор М. М. Дубинина. Экспериментальные данные адсорбции метана на графеновом аэрогеле были проанализированы с использованием типовой модели адсорбции Дубинина-Радушкевича в интервале температур 298.15-313.13 К. Характеристическая энергия адсорбции исследуемого газа (метана) на графеновом аэрогеле находятся в диапазоне 5.47-5.64 кДж/моль, что говорит о том, что процесс адсорбции метана на графеновом аэрогеле относится к физической адсорбции. На основе полученных данных рассчитаны зависимости дифференциальных мольных теплот адсорбции метана на графеновом аэрогеле от величины адсорбции при температурах 298.15-313.15 К. Теплота адсорбции составила 24 кДж/моль при всех температурах, а затем падала до ~9 кДж/моль при ~6 ммоль/г (298.15 К) и при ~4 ммоль/г (303.15-313.15 К). Такой ход кривых теплоты адсорбции, вероятно, является следствием особенностей пористой структуры адсорбента – мультимодальностью структуры. С молекулярной точки зрения само падение теплоты адсорбции при высоких заполнениях, по-видимому, связано с нарастанием энергии отталкивания между молекулами в адсорбате на малых расстояниях.
[RETRACTED] True Nature CBD Oil Reviews - Consumer Reports, Price, benefits v1
Authors: not provided truenatureoilreviewsfits
Published: April 2022

[RETRACTED]

True Nature CBD Oil Reviews - Consumer Reports, Price, benefits
As inovações tecnológicas na recepção e unidades habitacionais dos hotéis de luxo e bom conforto de Fortaleza (Ceará)
Authors: FONTENELE LIZIERY DE BRITO , TAVARES JEAN MAX
Published: April 2022

No turismo e na hotelaria, as transformações provocadas pela 4ª Revolução Industrial são responsáveis pela introdução de tecnologias e serviços não tradicionais em todos os subsetores. Na hotelaria, as inovações têm se dado mais no front-office e nos espaços internos das unidades habitacionais (UH). Dessa forma, essa pesquisa tem por objetivo identificar o processo de implementação de inovações tecnológicas nos hotéis de luxo e bom conforto de Fortaleza (Ceará), associadas ao setor de front-office e às unidades habitacionais. Realizou-se pesquisa descritiva, com aplicação de questionário, elaborado de forma a permitir uma abordagem quantitativa. Os resultados mostraram que a adoção das principais inovações tecnológicas verificadas na literatura e ligadas ao front-office e às unidades habitacionais ainda não fazem parte da realidade da rede hoteleira de Fortaleza; não obstante, existem alguns indícios de inovações.
Editorial
Authors: Zouain Deborah Moraes
Published: April 2022

Prezados leitores,É com grande prazer que apresentamos o primeiro número da Revista Acadêmica Observatório de Inovação do Turismo do ano de 2022!Aproveitamos para lembrar que, desde o ano de 2019, a revista passou a ter três números por ano (abril, agosto e dezembro).Tenham uma ótima leitura!
Platelets and other cells interactions in the atherosclerosis development
Authors: Parfenova Nina S.
Published: April 2022

Atherosclerosis of the blood vessels is one of the main causes of severe chronic vascular pathologies, which quite often lead to the fatal end. It is well known that the development of atherosclerosis is an inflammatory process going through several stages until the formation of an atherosclerotic plaque. The latter, due to increased instability, would come off and cause thromboembolism. Low density lipoproteins, endothelium, platelets, neutrophils, monocytes / macrophages and smooth muscle cells of the vessel wall are all active participants in the development of atherosclerosis. Thus, they trigger and carry out the process by forming a platelet thrombus on the surface of the ulcerated calcified atherosclerotic plaque. In the recent time interest in the role of platelets in inflammatory processes has grown immensely, first of all due to their ability to interact with cells participating in different stages of atherosclerosis development through adhesion, formation of aggregations, the exchange of exovesicles and microparticles, as well as through the mutually increasing secretion of cytokines, chemokines, growth factors and other chemical mediators. This review is devoted to the role of platelets in the formation and regulation of the multicellular ensemble and also local cell modules specific for each stage of atherosclerosis development.
Near-Source Attenuation and Spatial Variability of the Spectral Decay Parameter Kappa in Central Italy
Authors: Castro Raúl R. , Colavitti Leonardo , Vidales-Basurto Claudia A. , Pacor Francesca , Sgobba Sara , Lanzano Giovanni
Published: April 2022

We study the spectral decay parameter κ using S-wave recordings from the central Italy dense regional array. The data set used consists of 266 earthquakes, 353 stations, and 13,952 observations of κ with a mean value of 0.0412 ± 0.0177 within the distance range of 7.1–168.8 km. We model the variation of κ with hypocenter distance r as κ(r)=κ0+κs+κ˜(r), in which κ0 and κs represent the near-site and the near-source decay parameters, respectively, and κ˜(r) the average κ along the S-wave source-station paths. We first determine κ˜(r) with a nonparametric inversion approach and then we solved for κ0 and κs with a second inversion. We found that κ˜(r) increases with distance within the whole distance range analyzed (9.2–80.6 km). The near-source decay parameter takes values in the range 0.0<κs≤0.026 with a mean value of 0.003 ± 0.006, which represents 7.52% of the mean value of the observed κ. The values of the near-site decay parameter vary in the range 0.0035≤κ0≤0.0823 with a mean value of 0.0298 ± 0.0133, that is, 72.28% of the mean value of the κ observed. We conclude that most of the high-frequency attenuation takes place near the site, because κ˜(r) contributes with only 20.2% of the spectral decay. We also investigate the spatial variability of κ by determining κ˜(r) within four quadrants that divide the studied region taking as a reference axis the Apennines chain orientation. We found higher values of κ˜(r) in the southern quadrants, where seismicity and faulting are more active, and less attenuation in the more stable northeast quadrant.
P-Wave Velocity Structure of the Lower Crust and Uppermost Mantle beneath the Sichuan–Yunnan (China) Region
Authors: Wei Zhi , Zhao Li
Published: April 2022

We conduct a tomographic inversion for the 3D P-wave velocity structure in the lower crust and uppermost mantle of the Sichuan–Yunnan region in the southeastern margin of the Tibetan Plateau. A total of 43,450 reliable arrival times of P waves are picked from over 300,000 regional seismic records using an automatic algorithm based on deep learning. A two-stage iterative inversion process in which events are relocated, leading to a significant reduction in travel-time residuals, is adopted. A statistical resolution matrix analysis suggests that our model has an optimal spatial resolution length of ∼0.4° in the lower crust and ∼0.2° in the uppermost mantle. Our 3D model shows that both the lower crust and uppermost mantle in the region are characterized by strong lateral heterogeneities. The unusually low velocities in the lower crust may indicate the existence of lower crustal flow, whereas the high-velocity anomalies in the uppermost mantle in and around the Sichuan–Yunnan Rhombic block (SYRB) may be an important factor in preventing the ductile materials in the lower crust from moving eastward. Our model also indicates a coupling between the surface deformation and the material flow in the lower crust. Finally, the lower crustal flow may influence the materials in the shallow part of the uppermost mantle beneath the SYRB, and the crust–mantle transition zone beneath the Songpan–Ganzi block may be influenced by weak materials from both the uppermost mantle and the lower crust.
Exosome-mediated aptamer S58 reduces fibrosis in a rat glaucoma filtration surgery model
Authors:   Department of Ophthalmology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 401120, China, Lin Qian-Yi , Leng Yu ,   Department of Ophthalmology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 401120, China, Zhu Xiao-Min ,   Department of Ophthalmology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 401120, China, Tang Min ,   Department of Ophthalmology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 401120, China, Lin Yi ,   Department of Ophthalmology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 401120, China, Luo Wang-Du ,   Department of Ophthalmology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 401120, China, Jiang Bing-Cai ,   Department of Ophthalmology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 401120, China, Chen Xia ,   Department of Ophthalmology, Daping Hospital of Army Medical University, Chongqing 400042, China, Xie Lin ,   Department of Ophthalmology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing 401120, China
Published: April 2022

AIM: To confirm whether exosome-mediated delivery of aptamer S58 (Exo-S58) has a better antifibrotic effect than naked S58 in human conjunctival fibroblasts (HConFs) and a rat glaucoma filtration surgery (GFS) model.
METHODS: To enhance the effective reaction time of aptamer S58 in vivo, we loaded aptamer S58 into exosomes derived from HEK293T cells by PEI transfection to determine the effect of Exo-S58 in HConFs and a rat GFS model.
RESULTS: Exo-S58 can significantly reduce cell proliferation, migration and fibrosis in TGF-β2-induced HConFs. In an in vivo experiment, Exo-S58 treatment prolonged filtering bleb retention and reduced fibrosis compared with naked S58 treatment in GFS rats.
CONCLUSION: The exosomes are safe and valid carriers to deliver aptamers. Furthermore, Exo-S58 exhibited superior antifibrotic effect than naked S58 both in HConFs cells and rat GFS models.
Chordin-like 2 influences the differentiation fate of retinal pigment epithelium cells by dynamically regulating BMP pathway
Authors:   Department of Ophthalmology, the Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi 214000, Jiangsu Province, China, Li Duo , Xie Xin-Yi ,   Department of Ophthalmology, the Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi 214000, Jiangsu Province, China, Shen Han ,   Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, Jiangsu Province, China, Liu Qing-Huai ,   Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, Jiangsu Province, China, Yao Yong ,   Department of Ophthalmology, the Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi 214000, Jiangsu Province, China
Published: April 2022

AIM: To explore the functions of Chordin-like 2, which is encoded by CHRDL2, in the process of retinal pigmented epithelium (RPE) differentiation and damage repair.
METHODS: The fetal RPE cells (fRPE) was obtained from aborted fetus which obeyed medical ethics. Real-time quantitative polymerase chain reaction was used to measure expression quantity of CHRDL2 and other functional genes expression. Knocking down and overexpression was used to analyze the functions about Chordin-like 2. Enzyme-linked immunosorbent assay (ELISA) was used to detect the secretion of bone morphogenetic proteins 4 (BMP4). Flow cytometry was used to analyze cell cycle. Cell morphology was observed by phase contrast microscope (PCM).
RESULTS: In normal RPE cells, CHRDL2 was firstly upregulated and followed a downregulation but eventually, it was expressed higher than the cells which undergone epithelial-mesenchymal transition (EMT). After knocking down CHRDL2, the secretion of BMP4 was decreased, RPE-related genes (OTX2, MITF, RPE65) were downregulated while EMT-related genes (SNAI1, VIM) were upregulated. However, the expression of these related genes after overexpression of CHRDL2 had contrary results. Chordin-like 2 also regulated the cell cycle by regulating BMP pathway. When CHRDL2 was knocked down, more fRPE cells stayed in S phase of cell cycle, while adding BMP4 reduced the proportion of the cells in S phase. However, overexpression of CHRDL2 increased more BMP4 secretion, this effect decreased the number of cells in S phase, but exogenous BMP inhibitor also could change this effect. At last, in the process of RPE cells differentiation, adding BMP4 at early stage could intervene normal RPE differentiation. Compared with BMP4, inhibiting BMP pathway had no significant negative effect at early stage, but suppressed differentiation at late stage.
CONCLUSION: BMP pathway can be activated in a correct temporal order, otherwise, the cells have incorrect differentiation orientation. And Chordin-like 2 plays a role in dynamic regulation of BMP pathway and it also regulates the differentiation of RPE cells. Therefore, this research enlightens a new direction to inhibit EMT and promote cell redifferentiation after injury.
Clinical application of a shape-preserving rapid corneal donor dehydrater
Authors:   Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, Shandong Province, China; Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan 250021, Shandong Province, China, Sun Yu , Lin Xiao ,   Eye Hospital Affiliated to Shandong University of Chinese Medicine, Jinan 250004, Shandong Province, China, Zhang Xiao-Yu ,   Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan 250021, Shandong Province, China, Gao Li ,   Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan 250021, Shandong Province, China, Gao Hua ,   Eye Hospital of Shandong First Medical University (Shandong Eye Hospital), Jinan 250021, Shandong Province, China; State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, School of Ophthalmology, Shandong First Medical University, Jinan 250021, Shandong Province, China
Published: April 2022

AIM: To describe the design and clinical application of a corneal donor dehydrator which can quickly dehydrate corneas and keep its original shape.
METHODS: The corneal donor material is placed on stainless steel beads with different diameters in the dehydrating box to make the cornea the same shape as the steel ball. Then, the cornea is placed inside the dehydrater for rapid dehydrating using the internal cleaning and ventilation system. Totally 83 eyes underwent deep anterior lamellar keratoplasty (DALK) using corneal donor tissue preserved with corneal dehydrater, and 60 patients (60 eyes) received DALK by the same surgeon using corneal donor tissue preserved with glycerol were included in the control group. The best corrected visual acuity (BCVA), the thickness and transparency of the corneal buttons were recorded.
RESULTS: After the completion of dehydrating, all the donor corneas maintained a normal shape without any shrinkage or distortion, and the average intraoperative rehydration time was 43.3±12.1s during operation. The mean BCVA of the dehydrater group was 0.30±0.18 at 1wk and 0.32±0.16 at 1mo, which were statistically better than that of the control group (P<0.001). The score of corneal buttons transparency were lower than that of the control group with statistical difference (P<0.001). The thickness of corneal buttons at 1wk and at 1mo in the dehydrater group was significantly better than that of the control group respectively (P<0.001). One week after operation, no corneal button turbidity or edema was observed in both groups.
CONCLUSION: The dehydrater can quickly dehydrate the corneal material in a clean and airtight environment and maintain the original shape of the corneal donor during the dehydrating process. This dehydrater is recommended for long-term high-quality preservation in areas where corneal materials cannot be used within a reasonable time period.
Neuroretinal dysfunction in patients affected by neurofibromatosis type 1
Authors:   Department of Sense Organs, Sapienza University of Rome, Policlinico Umberto I, Rome 00161, Italy, Moramarco Antonietta , Mallone Fabiana ,   Department of Sense Organs, Sapienza University of Rome, Policlinico Umberto I, Rome 00161, Italy, Marcelli Michela ,   Department of Sense Organs, Sapienza University of Rome, Policlinico Umberto I, Rome 00161, Italy, Alisi Ludovico ,   Department of Sense Organs, Sapienza University of Rome, Policlinico Umberto I, Rome 00161, Italy, Roberti Vincenzo ,   Department of Dermatology and Venereology, Sapienza University of Rome, Policlinico Umberto I, Rome 00161, Italy, Giustini Sandra ,   Department of Dermatology and Venereology, Sapienza University of Rome, Policlinico Umberto I, Rome 00161, Italy, Lambiase Alessandro ,   Department of Sense Organs, Sapienza University of Rome, Policlinico Umberto I, Rome 00161, Italy, Nebbioso Marcella ,   Department of Sense Organs, Sapienza University of Rome, Policlinico Umberto I, Rome 00161, Italy
Published: April 2022

AIM: To examine neuroretinal function by using the multifocal electroretinography (mfERG) test in patients with neurofibromatosis type 1 (NF1) without optic pathway gliomas (OPGs).
METHODS: This study was conducted on 35 patients (35 eyes) with NF1 and 30 healthy subjects (30 eyes) for the control group. Each subject underwent a complete ophthalmological examination including spectral domain-optical coherence tomography (SD-OCT) and mfERG. The 1.5-Tesla magnetic resonance imaging (MRI) scan of the brain was performed in NF1 patients to assess the presence of OPGs. All participants were recruited having a best corrected visual acuity (BCVA) of no less than 20/20 in each eye. The amplitude and implicit time of the P1 wave (first-order Kernel component) were evaluated on mfERG. Data analysis was carried out in the two central degrees and in the four quadrants from two to 25 degrees of visual field.
RESULTS: Statistically significant results were obtained for the P1 wave amplitudes in the 4 quadrants in NF1 patients compared to healthy controls, while the reduction was not significant in the 2 central degrees between the groups. A statistically significant difference was observed among the P1 wave amplitudes as recorded in the 4 quadrants within the NF1 group, with lower amplitudes detected in the nasal quadrants. No differences in the implicit times were recorded in the 2 central degrees and in the 4 quadrants as compared between NF1 patients and controls.
CONCLUSION: Impaired neuroretinal function in NF1 patients is expressed in a decreased amplitude of the P1-wave between 2 and 25 central retinal degrees on mfERG. Altered intracellular signal transduction due to abnormal neurofibromin-mediated cyclic adenosine monophosphate (cAMP) generation, can be involved. The possible use of mfERG as subclinical retinal damage indicator has a potential utility in clinical practice for the follow-up of NF1 patients.
A randomized study of network-based perception learning in the treatment of amblyopia children
Authors:   Department of Ophthalmology, Eye and ENT Hospital Affiliated to Fudan University, Shanghai 200031, China; NHC Key Laboratory of Myopia (Fudan University), Zheng Chang-Yue , Wu Shun-Qiang ,   Key Laboratory of Myopia, Chinese Academy of Medical Sciences (Fudan University), Shanghai 200031, China, Han Dong-Xu ,   Key Laboratory of Myopia, Chinese Academy of Medical Sciences (Fudan University), Shanghai 200031, China
Published: April 2022

AIM: To compare the effectiveness of network-based perception learning (NBPL) and traditional training in the treatment of amblyopia children.
METHODS: This randomized controlled clinical trial recruited 56 participants aged 4-12y with anisometropic and/or strabismic amblyopia. Participants were randomly divided into two groups: the NBPL group (n=28) who received patching and NBPL for 3mo, and the control group (n=28) who got 3mo of patching and traditional training. Best-corrected visual acuity (BCVA) in the amblyopic eye and stereoacuity were measured and compared at baseline, 1, 2, and 3mo post-randomization.
RESULTS: There were no significant differences in age, gender ratio, and BCVA between the two groups at baseline. At 3mo, most patients gained lines (2 logMAR lines on average) of BCVA in both groups except one 11-year-old girl in the control group (P<0.05). But no significant difference in BCVA improvement of the amblyopic eye between the two groups was found (P=0.725), and amblyopia resolved (BCVA of 0.1 logMAR or better or within 1 logMAR line of the fellow eye) for 13 (46.4%) participants in both groups. The number of patients with improvement of stereoacuity was 25 and 13 in the NBPL group and control group (P=0.041), respectively, and a significant difference exists in the distribution of stereopsis at 3mo between the two groups (P=0.015). Besides, in patients with measurable stereopsis improvement degree and space for improvement in the two groups, the NBPL group also achieved better stereoscopic improvement than the control group (10/11 vs 4/11, P<0.05).
CONCLUSION: The NBPL system has a significant effect on the improvement of BCVA and stereoacuity of amblyopia children and is better than traditional training in terms of stereoacuity improvement. Perceptual learning visual training may play a more important role in the treatment of amblyopia in the future.
Genetic, environmental and other risk factors for progression of retinitis pigmentosa
Authors:   Eye Hospital, China Academy of Chinese Medical Sciences, Beijing 100040, China, Huang Zi-Yang , Li Ya-Min ,   Eye Hospital, China Academy of Chinese Medical Sciences, Beijing 100040, China, Xu Kai ,   Eye Hospital, China Academy of Chinese Medical Sciences, Beijing 100040, China, Li Xiao-Yu ,   Eye Hospital, China Academy of Chinese Medical Sciences, Beijing 100040, China
Published: April 2022

Retinitis pigmentosa (RP) is a commonly inherited disease of the retina, which is characterized by progressive loss of visual function due to specific genetic mutations. There are many risk factors that may have effect on the progression of RP, such as inheritance patterns, genotype, gender, age, smoking, physical activity, and other demographic and environmental factors. Baseline visual field conditions, changes of ellipsoid zone, photoreceptor layer thickness, and choroidal structure are reported to be the phenotype risk factors for RP progression. Moreover, aqueous flare and high-sensitivity C-reactive protein are probable inflammation biomarkers for assessing the progression of RP. Increased oxidative stress is considered to be one of the potential factors for the existence of RP. The risk factors can be combined to form a corresponding prediction model to predict disease progression. This review is to summarize the current literature that studies the genetic, environmental, phenotypic, demographic, inflammatory and other risk factors of RP progression and discuss the most reliable risk factors that could provide predictive models.
Estudio arqueomagnético del piso quemado en La Palma, valle de Cuzalapa, Sierra de Manantlán (Jalisco)
Authors: Pomedio Chloé Marie , López Verónica , Goguitchaichvili Avto , Cejudo Rubén , Morales Juan , Soler-Arechalde Ana María , Cervantes-Solano Miguel , García Rafael
Published: April 2022

Las primeras exploraciones realizadas por el proyecto Arqueología de la Sierra de Manantlán, en el valle de Cuzalapa, al sur de Jalisco, arrojan datos sobre la ocupación prehispánica de esta región hasta ahora poco estudiada desde el punto de vista arqueológico. El hallazgo de varios sitios de arquitectura y manifestaciones gráfico-rupestres plantean la cuestión de la temporalidad de estos vestigios. Las condiciones complicadas para el trabajo de campo y la escasez de artefactos diagnósticos han dificultado la construcción de una cronología. El presente trabajo se inscribe dentro de las investigaciones de frontera entre la arqueología y geofísica (paleomagnetismo y arqueomagnetismo), para datar arqueomagnéticamente un piso de estructura sencilla en el sitio de La Palma. Aun tratándose de una datación aislada dentro del conjunto de evidencias registradas, este estudio permite ubicar tentativamente la ocupación del valle de Cuzalapa en el periodo Posclásico Temprano (900-1200 d.C.) y esbozar una primera interpretación de las dinámicas culturales posibles en el contexto extrarregional del desarrollo de la red Aztatlán.
Lineament mapping in the Central High Atlas using ASTER and ASTER-GDEM data, (Morocco)
Authors: Farah Abdelouhed , Algouti Ahmed , Algouti Abdellah , Ait Mlouk Mohammed , Ifkirne Mohammed
Published: April 2022

The present work focuses on lineament mapping using new spatial remote sensing techniques in the central High Atlas (CHA) of Morocco. In this study, the automatic extraction of lineaments was based on using multispectral images type Advanced Spaceborne Thermal Emission Reflection Radiometer (ASTER, L1B) with high spatial resolution up to 15 m for the visible/near-infrared (VNIR) bands. Besides, a digital elevation model (DEM) type ASTER GDEM was used with a spatial resolution of 30 m. The satellite image was pre-processed before the automatic extraction of the lineaments using the mathematical algorithm Line Module of the PCI Geomatica software 2016. Then, multisource data, such as an extract of the Ouarzazate Alougoum geological map (1/100000) covering the entire study area and a calibrated field imaging background (source: Esri, Maxar, GeoEye, Earthstar Geographics, CNES/Airbus, DS, USDA, AeroGRID, IGN, and the GIS User Community), was used for validating the results. The extraction of the lineaments from the first principal component (PC1) image was derived from the satellite image and the DEM. These results proved that each produced map has a strong similarity in concentration and orientation with three major directions including NE-SW, E-W and ENE-WSW. We observed a high concentration of these lineaments in both the central and northern parts of the study area as well.
Emerging of the mineralogy discourse in Mexico (1795-1849): a taxonomy of objects, procedures, and instruments
Authors: Valencia-Martínez Andrea , Mondragón-Colín Carlos Alberto , Collazo-Reyes Francisco , Pérez-Angón Miguel Ángel
Published: April 2022

We carry out a documentary analysis of the texts on mineralogy produced in and about Mexico from 1750-1849. The objective was to extract the names of the objects, procedures, and instruments (OPI) used in the texts for teaching, research, or improving minerals’ production. OPIs names are considered as rhetorical regularities in the discursive structure of the mineralogy texts. Their identification and characterization in the texts were carried out employing a manual XML tagging differentiated by colors. The objects’ names, procedures, and instruments were identified and organized as taxonomical elements and differentiated according to their frequency. The texts were analyzed according to the objective, the social sector (teaching, research, production), and the argumentative style The analysis reveals the diversification of the rhetorical functions of OPIs in the content structure of the texts. It is an emergent argumentative style that presents the results through the relationship of facts between the IPOs. Thus, the reproducibility of the results function emerges as a qualitative novelty in scientific communication. Development of the taxonomies of OPIs led to representations of the early form of the discourse in Mexican mineralogy.
Influence of Biopores Infiltration Holes on the Level Erosion in Oil Palm Plantations Area
Authors: Devianti  , Irwansyah  , Yunus Yuswar , Arianti Nunik Destria , Thamren Dewi Sartika , Sitorus Agustami
Published: April 2022

The extension of oil palm plantations in Indonesia has encroached on land with a slope of more than 15%, which impacts the possibility of erosion and landslides. However, conservation efforts to reduce erosion are yet to be fully established. Therefore, the present work studies the effect of biopores infiltration holes on erosion at oil palm plantations area with land slopes greater than 15%. Besides, surface runoff with erosion is modeled to find the relationship. The method used in this study is to combine mechanical conservation methods in the form of biopores infiltration holes in an area that already has cover crops, such as Mucuna Bracteata. Two experimental plots were designed, namely (i) plots without biopores infiltration holes and (ii) plots with biopores infiltration holes. The results showed that soil erodibility in the oil palm plantations area was of a high of 0.65. Applying biopores infiltration holes in the field reduced surface runoff and erosion rates by 31.81% and 29.66%, respectively. The relationship of surface runoff with erosion rates on the land shows a very close case where the coefficient of determination in each plot is 0.96 and 0.92.
Experimental Approach for Treatment of Contaminated Soil with Crude Oil
Authors: Abdulkarim Taha Ibadalden , Abdulla Ali Hasan
Published: April 2022

Oil is considered one of the most dangerous sources of environmental pollution, especially for the soil, as it turns it into sterile soil that is not suitable for animal, plant or any living thing. Therefore, in this research, we will use four methods to treat soil contaminated with crude oil, where animal and plant fertilizers were used at rates of 20% and 40% in each method, with both types active and inactive, on samples of contaminated soil, after preparing these samples they were compared with each other by analyzing the data and the results of scientific experiments held on the samples. Where the results of the treatment of contaminated soil, and by using some of these methods, showed an increase in the ratio of bacteria beneficial to the soil and at the same time an increase in the ratio of organic materials feeding the plant, because of the existence of types of bacteria in these fertilizers that eliminate or feed on the toxic oil compounds that exists in the soil, in addition to this activating and providing the soil again with bacteria that are beneficial to it. After we applied the treatment processes and scientific experiments, it became clear that the method (B1) using animal fertilizer (sheep manure) after adding a quantity equal to 40% of the sample gives the most positive result when treating soil contaminated with crude oil.
Rebuilding Ramadi in Concept of a Fractured City and Rules of Urban Coherence
Authors: Ahmed Joan Atheel , Saeed Ahmed Adnan
Published: April 2022

The suffering and trauma resulting from destruction of cities has generated an intense reaction to citizens, civil organizations and university gathered together and voluntarily to formulate general policies that can restore normal life to work in region and guide and guide reconstruction. Some may press for years for a particular city and regional improvements Such as mass transit, housing, public places, riverfront development, social and economic justice, as well as good urban design. The orientation and guidance of work and reliance on certain principles and rules requires representatives of city to adopt concepts that move from complexity to simplicity and looking for diversity and interdependence and organization within certain limits and hierarchical hierarchy achieves desired urban cohesion and destruction that city has opportunity to apply this within concepts are catalysts for process of interaction among different composites in city, it facilitates occurrence of any gathering can be system-wide. As for urban form, there are no stimulus parts, but every structure or component of urban form is working at least two other components. The various components are interconnected randomly to be integrated into final components of each organic freely interacting between different elements and components. The research deals with formulation of an indicative guide drawn from concept of fractal city and rules of urban cohesion in reconstruction of city of Ramadi "destructive" with community participation at all levels restore city's historical and cultural identity and other aspects that keep it as a living city as a functional, social, environmental and service.
Początki piśmiennictwa krajoznawczo-turystycznego w Uniwersytecie Jagiellońskim (XV wiek – połowa XVII wieku)
Authors: Jackowski Antoni
Published: April 2022

W artykule podjęto próbę nakreślenia początków piśmiennictwa turystycznego i krajoznawczego, którego autorami byli profesorowie i wychowankowie Akademii Krakowskiej. Większość stanowią dzieła geograficzne i kartograficzne. Spośród wielu autorów wymienić należy zwłaszcza Jana Długosza, Wawrzyńca Korwina, Jana z Głogowa, Macieja z Miechowa (Miechowity), Bernarda Wapowskiego, Marcina Kromera.
Paradygmat terytorialności w turystyce kulturowej
Authors: Jansen-Verbeke Myriam
Published: April 2022

Typowe podejście geografów do turyzmu zakłada nacisk na analizę ruchu turystycznego w przestrzeni i sposoby korzystania z tej przestrzeni, jak również na syntezę spójności terytorialnej pomiędzy ludźmi, miejscem a produktem. Nowe zainteresowanie terytorialnymi aspektami turyzmu może być postrzegane z jednej strony jako reakcja na globalizację, a z drugiej jako poszukiwanie unikatowych, autentycznych i doświadczeń grass-rooted. W ostatnich badaniach centrum uwagi zostało przeniesione z opisu prawidłowości na analizę procesu zmian spowodowanych przez turyzm („turystyfikacja”). Zrozumienie sił, które przekształcają krajobrazy kulturowe (miejskie i wiejskie) w krajobrazy turystyczne jest podstawowym warunkiem wizjonerskiego planowania i odpowiedzialnego zarządzania regionami i miejscowościami. Artykuł zawiera kilka refleksji na temat przyszłych badań geoturystycznych.
Stacje górskie – ich geneza i ewolucja
Authors: Kowalczyk Andrzej
Published: April 2022

W proponowanym artykule zostaną przedstawione przesłanki pojawienia się „stacji górskich”, ich rodzaje oraz zmiany, jakie zaszły w ich sposobie funkcjonowania. Niektóre problemy teoretyczne i praktyczne zostaną przedstawione na przykładach z Europy, Ameryki Północnej, Azji i Afryki.
Aktywizacja nadmorskiego obszaru recepcji turystycznej przy wykorzystaniu instrumentu Partnerstwo Publiczno-Prywatne
Authors: Szwichtenberg Aleksander
Published: April 2022

Partnerstwo Publiczno-Prywatne jest formą współpracy pomiędzy sektorem publicznym i prywatnym w celu realizacji projektu lub świadczenia usług tradycyjnie dostarczanych przez sektor publiczny. Ten tryb realizacji inwestycji stosuje się najczęściej przy budowaniu projektów z zakresu infrastruktury technicznej. Zdaniem autora PPP pozwoli turystycznym gminom nadmorskim na przyspieszenie realizacji infrastruktury komunikacyjnej i sportowo-rekreacyjnej, które obecnie są głównymi barierami rozwoju ich gospodarki turystycznej. Potwierdzają to m.in. przedstawione w niniejszej pracy przykłady.
Practice what you preach: Importance of veterinarian involvement in zoonotic disease prevention – A Michigan focus
Authors: Baiyasi Stephanie , Juárez Rubén , Brookins-Fisher Jodi , Inungu Jeff , Gehring Thomas , Kozicki Zigmond
Published: April 2022

Objective: Determine the extent to which practicing veterinarians in Michigan, USA engaged in commonly recommended practices for the prevention of zoonotic diseases (ZDs).

Background: Follow-up to Lipton et al. (2008) Washington State study.

Methods: Online survey link was emailed February 2020 to 3,410 Michigan licensed veterinarians practicing clinical medicine with emails on file with Michigan Licensing and Regulatory Affairs.

Results: 402 veterinarians responded. A high proportion (161/214 [75%]) of respondents agreed it was very important for veterinarians to advise clients about the potential for ZD, yet only 34% (74/215) reported they had initiated discussions about ZDs with clients on a daily basis, although 64% (137/214) indicated they had client educational materials on ZDs available in their practices. Nearly 62% (47/76) of veterinarians who obtained their degree after 2010 were likely to eat / drink in animal handling areas as compared to only 33% (18/54) of those who graduated before 1989. Over 30% of respondents (64/210) indicated there were no written infection control guidelines for staff members in the practice, and 28% (60/214) reported having been infected with a ZD in practice.

Conclusion: Veterinarians appreciate their important role in ZD prevention and welcome increased communication between human and veterinary medicine plus assistance from public health agencies regarding ZD prevention. Communication / coordination / collaboration among human medicine / animal medicine / environmental health (i.e., One Health) is necessary to protect the public’s health from zoonoses.