bluuebunny/crossref_metadata_2025 huggingface dataset:
Embryonic Stem Cell Ethics
Authors: Vian Hussam Almansi Alqani  , Mudhfar Mohammed Meizel
Published: July 2024

The usage of “human embryonic stem cells” in modern medicinal usage is one of the most recognizable methods nowadays, used to treat damaged cells and tissues that promise hope for the future to treat numerous diseases. The main issue is that multiple countries worldwide have faced complex ethical and legal questions as an outcome of enhancing all of these cell replacement therapies. The main motive of this paper is to review an article by John A. Robertson, which dealt with the “ethical and legal issues of human embryonic stem cell research”. The report has concentrated its fact on moral and legal factors. Still, the main purpose of this study is to review the ethical factors presented by the research article and analyze the outcome. The paper has also focused on making analytical discussions on other pieces to support the aspect of the preliminary article. The main of the paper is to lay out information for future researchers to understand the ethical considerations of “human embryonic stem cell research.
Effect of Topical Curcumin on Tinea Unguium
Authors: Kawther Mohammed Radah Ali
Published: July 2024

Onychomycosis is one of the prevalent fungal infections that occur in the nails, and this paper has straight forwardly discussed this fungal infection. Fungal infection of the nail is a worldwide infestation caused by a specific fungal family known as tinea unguium. Although it is not a serious condition, its treatment may be prolonged with an optimal medical approach and, if not treated well, may induce disseminated fungal spread to other skin sites and cause cosmetic deformities. Curcumin is a well-known plant extract that has been used for many centuries for many purposes like cooking and coloring agent and recently used for many clinical conditions as it has pleiotropic biological effects like anti-inflammatory, antioxidant, immune modifier and many other effects. Aim of the study: to evaluate if Curcumin has an additive effect when used with terbinafine (a traditional anti-fungal agent used for this condition) when applied topically. Patients and method: 312 patients were randomly selected and separated into two groups. Group I used terbinafine only, and group II used terbinafine and topical Curcumin for one week for both groups. Results: there was a significant cure rate in group II compared to group I am suggesting that Curcumin has a potential anti-fungal effect.
Evaluation of Undifferentiated Carcinoma from an Unidentified Primary Origin (Review Articles)
Authors: Zainab.Al-Ali  , Mostafa A. alwash  , Zena Mahdi Abd Ali
Published: July 2024

Cancers with an unidentified primary site at the start of treatment are classified as cancers with an unknown original primary site. Their prevalence among cancer patients is around 5%. One of the challenges in medicine is an approach to those patients. The requirement for the early detection of malignancies or palliative care are still problem in medicine. A strategy for their treatment should be created to avoid prolong hospital stays and testing that won't improve therapy or the prognosis for those sufferers.
 It's crucial to identify individuals whose diseases have good prognoses since they may benefit greatly from targeted therapy, including longer survival. A targeted search for the main tumor in those patients is advised. However, for those patients who will effectively employ targeted therapies, the combination of a robust immunohistochemistry panel with novel molecular knowledge may enable the development of a specific management strategy
A Case-Control Study assessing Serum Galectin 3 level in Atrial Fibrillation Patients
Authors: Mudhafar S. Khazaal  , Hassan H. Al-salamy  , Ali H. Shaalan
Published: July 2024

As a worldwide issue of concern, atrial fibrillation (AF) casts a huge burden on the health care system. Not only being an arrhythmia of high frequency and prevalence, but also due to the chronicity of some its types. It is imperative to increase the understanding of the pathophysiological basis behind atrial fibrillation or at least the processes that sub serves as a prerequisite for its development. Cardiac remodeling and fibrotic changes may derange the conductive properties of the myocardium and hence import an arrhythmogenic conditioning state. Galectin-3 (Gal-3) has a wide spectrum of biological activities. It can be utilized as a tool for screening many cardiac conditions especially those associated with fibrotic states.
Aim of study: this study was designated to explore the association between atrial fibrillation and serum galectin-3 levels. It was of a case-control type that comprised a cohort of 58 patients with atrial fibrillation, together with 30 controls without it. Patients were categorized into two categories depending upon whether they have a persistent or permanent atrial fibrillation. Serum galectin-3 was measured using ELISA technique, and the results were compared among the three groups.
Results: The Gal-3 was found to be higher in patients with permanent AF (p < .0001) where it recorded 19.27 ± 4.58 ng/ml. The rise in the marker concentration was statistically significant when compared to the 13.54 ± 4.9 ng/ml and 12.14 ± 4.69 ng/ml for the persistent AF and control groups, respectively. Likewise, patients with permanent AF had significantly higher values of left atrial diameter (LAD) (p < .0001) with a mean of 4.68 ± 0.37 cm, 4.09 ± 0.3, and 3.54 ± 0.32, for the permanent AF, persistent AF, and the control groups, respectively. Additionally, the LAD revealed a slight positive correlation with the Gal-3 level, r (56) = 0.386, p < 0.003, with an r2 of 0.149. On the other hand, there was a significant reduction in the left ventricular ejection fraction (LVEF %) in patients with permanent AF, p < 0.0001. The LVEF% was 53.27 ± 7.35 %, versus 62.13 ± 6.75 %, and 63.39 ± 5.77% for permanent AF, persistent AF, and control groups, respectively.
In conclusion, serum Gal-3 is elevated in conditions of both, long-standing AF as well as newly diagnosed AF. The marker correlated positively with the LAD and negatively with LVEF%. Furthermore, LVEF% revealed a moderate negative correlation with serum Gal-3 concentrations. The study concluded that as the left atrium increases in size, this will impose a deleterious effect on the left ventricle and will be reflected as an increasing level of the marker. Hence, Gal-3 can be used as a tool for evaluating fibrotic changes in patients with AF especially the chronic types.
Analisis Profesionalisme Guru Pendidikan Agama Kristen dalam Transformasi Pembelajaran Berbasis Kurikulum Merdeka
Authors: Manga’ Friskianti , Suardana I Made , Tari Ezra
Published: July 2024

Tulisan ini mengkaji proses penyesuaian guru dengan kurikulum. Karena pergantian kurikulum dan kebijakan pendidikan yang sering terjadi memerlukan adaptasi yang cepat dan berkelanjutan dari pihak guru. Guru sering mengalami kesulitan untuk memperoleh akses ke pelatihan profesional yang berkelanjutan dan dukungan dari rekan kerja serta manajemen sekolah.  Metode yang diterapkan adalah deskriptif kualitatif. Metode penelitian digunakan untuk menggambarkan dan memahami fenomena atau realitas sosial yang rumit dengan cara menyelidiki pengalaman, persepsi, atau pandangan subjek yang sedang diteliti. Kurikulum Merdeka menekankan pada kebebasan dan fleksibilitas dalam proses belajar-mengajar, dengan tujuan utama untuk mengembangkan kompetensi siswa secara holistik. Guru Pendidikan Agama Kristen (PAK) memiliki peran penting dalam implementasi kurikulum ini, karena mereka tidak hanya berfungsi sebagai pengajar, tetapi juga sebagai pembimbing spiritual bagi siswa. Guru Pendidikan Agama Kristen diharapkan mampu mengarahkan siswa dalam meningkatkan kemampuan belajar secara mandiri, mengajar mereka cara mengakses dan memanfaatkan berbagai sumber belajar. Pengembangan program pelatihan bagi guru, integrasi teknologi dalam peningkatan kolaborasi dalam pembelajaran untuk mendukung implementasi kurikulum merdeka dengan lebih efektif.
Prevalence of Wuchereria bancrofti Infections in Tokha-Chandeshwori Village Development Committee, Kathmandu, Nepal
Authors: Bhusal Krishna Prasad , Joshi Anand B. , Mishra Purna Nath , Bhusal Kalpana
Published: July 2024

Bancroftian filariasis is endemic in many areas of Nepal. This study describes the infection and intensity of Wuchereria bancrofti in the Kathmandu valley. The real burden of Wuchereria bancrofti in most endemic areas remains unknown even through it is a major public health problem in many communities, particularly semi-urban areas of Nepal. This study describes the infection and intensity of Wuchereria bancrofti in Tokha-Chandeshwori VDC, the Kathmandu valley. The nocturnal periodicity of the parasite requires parasitological examinations to be done at night. The aim of this study was to develop and validate rapid epidemiological assessment tools for the community diagnosis of Wuchereria bancrofti that maybe used in the future to determine the distribution of the disease and identify high-risk communities in Nepal. A survey of 978 nocturnal blood film in this VDC indicated an overall prevalence of 5.8% for microfilaraemia. And crude disease rate of Wuchereria bancrofti was recorded to be 13.0% in the study area. The highest microfilaraemia infection rate was recorded as 11.8% among age group of 40-49. And the highest crude disease rate was recorded 36.4% in the age group of 70 and above.
Malnutrition in children under 5 years of age in Chisapani and Sutaiya (Banke) villages
Authors: Bhatia V , Manandhar N
Published: July 2024

Malnutrition is one of the major public health problems in developing countries including Nepal. Malnutrition not only directly affects the children by reducing their physical and mental performance but also makes the situation worse by making the child susceptible to infections. The long-term effects of malnutrition also need to be highlighted. Those suffering from malnutrition in early parts of their life tend to have lower weight even during adult life. The physical work capacity is hence reduced. The present study was conducted in the rural areas of Chisapani and Sutaiya (Banke). The total sample size taken in the study was 137. The study was conducted with the help of 5 volunteer students of the college. The anthropometric measurements of children were taken. To assess the degree of malnutrition the weight/height (length) ratio was compared to the WHO/NCHS standards and stunting was also taken into account. The result puts the total of malnourished children in the study group to 63 (46.4%). On drawing comparisons, malnutrition was found to be associated with female sex, joint family and the total number of children in the family. It is thus felt that the children in these villages need special attention. This can be done by providing nutritional education to the parents and among other things by bringing on a social change so that the female child is not neglected.
Prescribing trend of fixed-dose drug combinations in a tertiary hospital in Nepal
Authors: Sarkar C. , Das B.
Published: July 2024

The objective of this study was to analyze the prescribing trend of the different fixed-dose drug combinations (FDCs) in a tertiary hospital in Nepal. A retrospective study was conducted after collecting prescriptions from patients attending Manipal Teaching Hospital, Pokhara. The rationality of FDC formulations were studied on the basis of FDCs recommended by Department of Drug Administration (DDA), Ministry of Health (MoH), Nepal and the World Health Organization (WHO). An audit of the prescriptions revealed that 40% of the prescriptions contained FDC formulations. However, FDCs in accordance with recommended DDA, MoH Nepal and WHO lists of FDCs were only 0.8% and 2.1%, respectively. The most commonly prescribed FDCs were multivitamins, cough and cold remedies and antimicrobials which constitute nearly 63% of the total FDCs prescribed. In 48.4% of the prescriptions, the prescribed FDCs contained ingredients which were not essential for the desired therapeutic effect. Nearly 98% and 95% of the FDCs prescribed did not conform to the recommended Nepal and WHO lists of FDCs, respectively. The prescription of certain FDCs, however, were justifiable and in accordance with rational drug usage.
Organophosphate poisoning: the importance of the intermediate syndrome
Authors: Basnyat Buddha
Published: July 2024

Organophosphate poisoning is the commonest poisoning in Nepali hospitals, partly due to the easy access of these pesticides from the market. This case report emphasizes the need to closely monitor patients with organophosphate poisoning so that the intermediate syndrome, a well known, life threatening phenomenon related to this poisoning, can be effectively dealt with. The pathophyiology and treatment of the intermediate syndrome is discussed.
Sarcoma Botryoid of Vagina and Cervix in a three year old girl
Authors: Rana Ashma , Gurung Geeta , Devkota Krishna , Amatya Archana , Joshi Prof. B.R. , Baral Josie , Pradhan Neelam , Sharma Rashmi , Giri Prof. Kanti
Published: July 2024

A three year old with three months history of abdominal lump, blood mixed vaginal discharge and occasional urinary retention was operated as a case of sarcoma botryoid of vagina and cervix. This was proven histologically. With surgery it was possible to remove a huge mass arising from cervix and vagina measuring 10X10 cm. It was almost mimicking central cervical myoma. Initial surgery was observed to be beneficial in this case as it showed immediate good results by providing reduction of total tumour mass. She was planned for combination chemotherapy with VAC; however she developed abdominopelvic recurrence very soon.
Eksistensi Perempuan Dalam Novel Kinasih Karya Nisaul Kamilah Chisnulloh: Kajian Feminisme Eksistensialis
Authors: Reni Isnaini Pratiwi  , Riski Putriani
Published: July 2024

Abstrak. Artikel ini menganalisis Novel “Kinasih” krya Nisaul Kamilah Chisnulloh, sebuah karya sastra yang menampilkan sebuah perjalanan emosional dan pencarian jati diri seorang wanita muda yang bernama Kinasih dalam konteks kebudayaan jawa yang kental. Dari karakteristik yang mendalam, Nisaul Kamilah menampilkan sosok yang kuat hamun rentan, berjuang dengan dilemma dan konflik yang mencerminkan pergulatan internak individual dalam masyarakat modern. Setting yang terdapat dalam novel ini mencakup kehidupan di desa dan kota, dengan memberikan latar yang hidup dan mempengaruhi pada perkembangan alur cerita dan juga karakter. Tema yang diusung pada novel ini mencakup cinta, kehilangan, pencarian identitas, serta isu-isu sosial seperti peran perempuan dan dampak globlalisasi pada penggunaan elemen tersebut untuk menyimpan pesan mendalam tentang nilai tradisional dan perubahan sosial. Pada pendekatan ini mencakup penelusuran karakteristik, dinamika hubungan antara tokoh, deskripsi setting dan penggambaran tema. Selain itu juga gaya dalam bahasa dan teknik penulisan yang puitis dan deskriptif yang dibahas dalam memahami kontribusinya untuk memperkaya narasi. Melalui analisis ini, diharapkan pembaca dapat mengapresiasi novel “Kinasih” sebuah karya satra yang tidak hanya menawarkan cerita menarik, namun menjadi refleksi dalam kehidupan dan budaya. Dari novel ini dapat menjadi cerminan yang relevan bagi pembaca dalam memehami diri sendiri serta dunia yang mereka huni. Novel ini akan menganalisis eksistensi pada tokoh perempuan yaitu; (1) Eksistensi karakter utama “Kinasih” menantang stereotip gender; (2) Kekuasaan yang mempengaruhi kehidupan perempuan; (3) Pengaruh tokoh laki-laki terhadap tokoh utama.
Kata Kunci: Perjuangan perempuan, kekuasaan dan penindasan, solidaritas antar perempuan.
Estrategias didácticas motivacionales, recursos para el aprendizaje en la carrera de ingeniería en mecatrónica: TecNM/campus Tláhuac
Authors: Ramírez Castillejo Griselda
Published: July 2024

La realización de esta investigación tuvo como base establecer la relación entre la implementación de las estrategias didácticas motivacionales de los docentes que impartieron las materias de primer semestre de la carrera de Ing. en Mecatrónica en el ciclo agosto-diciembre 2023 en el Instituto Tecnológico de Tláhuac con los índices de aprobación que se obtuvieron como resultado al final del semestre.
La investigación se realizó a partir de  una encuesta aplicada a una muestra de 75 estudiantes, se desarrolló una metodología con enfoque cuantitativo y un diseño descriptivo-correlacional; el análisis de los datos se llevó a cabo con el software SPSS Statistics, en donde los resultados que se obtuvieron marcan las correlaciones significativas y muy significativas con los rangos del  95% al 99%, que se basan en la veracidad de los datos, la relación entre las variables tiene como resultado variabilidad en su significancia porque se presenta como positiva baja, moderada y alta; con lo cual se puede determinar que en los distintos grupos la implementación de estrategias didácticas motivacionales y el índice de aprobación  no tuvieron el mismo grado de correlación.
 Es necesario hacer notar que en los resultados obviamente no se incluyeron alumnos que desertaron en las diferentes materias o quienes las estaban recursando, esto básicamente porque no se planteó como parte de los objetivos, además quienes recursan no lo hacen en todas las materias y quienes abandonan la carrera lógicamente no finalizan el curso.
Perancangan Antarmuka Aplikasi Serve-U Dengan Metode Design Thinking
Authors: Suparto Adrian , Clement Michael Joy , Pratama Brilliant Chandra , Ferliansyah Fernando , M Lazuardi Ferdillian  , Pribadi Muhammad Rizky
Published: July 2024

Era digital telah memberkati orang-orang dengan alat-alat luar biasa yang dapat membuat hidup mereka jauh lebih mudah, dan desain UI/UX (User Interface/User Experience) juga merupakan salah satunya. Dengan menempatkan pengguna sebagai pusatnya, metodologi Design Thinking membantu mengembangkan solusi yang efektif. Salah satu masalah global yang paling mendesak, yang bahkan lebih umum terjadi di negara-negara berkembang, adalah pengangguran dan ketidakcocokan pekerjaan yang terjadi sebagai akibat dari kesenjangan antara peluang kerja yang tersedia dan keterampilan pencari kerja. Teknologi telah menawarkan solusi dengan menyediakan platform yang dapat diakses oleh para penyedia jasa tanpa memandang sertifikasi akademis mereka. Dikembangkan dengan menggunakan Design Thinking, Serve-U memungkinkan pengguna untuk mengidentifikasi layanan mikro yang penting seperti layanan transportasi, kurir, atau pembantu rumah tangga yang dibutuhkan di daerah perkotaan. Makalah ini memberikan prototype yang mudah digunakan dan efektif antara pengguna dan penyedia layanan untuk melakukan pekerjaan mikro, yang mulai mengatasi masalah perkotaan.
 
Kata Kunci: Design Thinking, ketenagakerjaan mikro, pengalaman pengguna, aplikasi mobile, layanan perkotaan.
Algorithmic approach leveraging a real-time task scheduler with fan-out strategy
Authors: Larios-Gómez Mariano , Anzures García Mario , Cerón Garnica Carmen , Sánchez Gálvez Luz A.
Published: July 2024

This study focuses on the communication challenges among processes in mobile drone systems, specifically addressing the dynamics and decentralization of their topology. An algorithmic approach for real-time systems is proposed, emphasizing its application in drones. The Fan-shaped Real-Time Task Scheduling Algorithm (APTTRA) serves as the cornerstone, distributing processes with deadline constraints in a fan-shaped manner to ensure timely completion. It introduces a metric that evaluates not only task compliance but also when and how long, providing a comprehensive insight into the system's effectiveness. To support performance evaluation, the use of a connected acyclic graph is proposed, offering a detailed understanding of performance across various process sections. The system's adaptability is highlighted through the incorporation of variables in real-time applications, providing a complete view in dynamic situations. Along with the use of Minix as a modular operating system, allows for testing APTTRA before implementation in real drones. The importance of real-time task scheduling for drones, especially helicopters and quadcopters, is emphasized, underscoring the need to tailor control algorithms. The evaluation focuses on implementation, successes in real flights, and the application of APTTRA in a genetic algorithm for calibration within the planning ranges.
Classification of Long COVID Pulmonary Fibrosis Based on Computed Tomography in Mexican Patients
Authors: Hernandez-Trinidad Aron , Guzman-Cabrera Rafael , Ruiz Pinales José , Cordova-Fraga Teodoro
Published: July 2024

In this study, we focus on addressing the prolonged effects of COVID-19, specifically pulmonary fibrosis, through automated classification of computed tomography (CT) images from patients in León, GTO, Mexico. We employed a convolutional neural network (CNN) VGG16 along with image enhancement filters, such as Meijering and Roberts, to optimize image quality. Prolonged COVID has been linked to complications, including pulmonary fibrosis, underscoring the need for early detection. Our model, supported by a comprehensive dataset, achieved classification accuracy exceeding 97%, successfully distinguishing between patients with and without pulmonary fibrosis. The combination of enhancement filters and CNN VGG16 proved crucial in this success, highlighting the potential of our model for early detection and effective management of pulmonary fibrosis in long COVID patients. This promising approach may have a significant impact on clinical practice, enhancing outcomes and enabling timely interventions. In summary, we present an effective method contributing to timely diagnosis and treatment of pulmonary fibrosis in long COVID patients.
Formulation and Evaluation of Fast Dissolving Tablets of Atorvastatin Calcium using Starch Malonate
Authors: Singh Sakshi , Indurkhya Arpna
Published: July 2024

Fast dissolving tablets containing Atorvastatin calcium were prepared using the direct compression method with various superdisintegrants and evaluated for hardness, friability, weight variation, disintegration time, wetting time, and in vitro drug release. The precompression characteristics indicated good flow properties and compressibility of the drug with the excipients. Post-compression evaluations showed uniform hardness, thickness, and diameter across all tablets, ensuring uniform size, shape, and good resistance to mechanical damage. The weight variation of all formulations was within prescribed limits. The FDTs containing Starch Malonate demonstrated rapid disintegration and dissolution, with formulation F3 showing a disintegration time of 21 seconds, outperforming formulations with crosspovidone and croscarmellose sodium. Increased concentrations of Starch Malonate, crosspovidone, and CCS corresponded with decreased disintegration times. Starch Malonate exhibited the fastest wetting time, followed by crosspovidone and CCS, underscoring its superior disintegration power. The wetting time correlated with disintegration time in the oral cavity, highlighting the disintegrants' capacity to swell in minimal water. In vitro studies indicated rapid drug dissolution within 10 minutes, attributed to the quick breakdown of particles and rapid drug absorption into the dissolution medium. In conclusion, incorporating Starch Malonate as a superdisintegrant in Atorvastatin Calcium FDTs effectively promoted rapid disintegration and drug release, offering potential advantages in patient convenience and compliance, especially for those with swallowing difficulties or preferences for orally disintegrating dosage forms.
História da Educação de Jovens e Adultos (Eja) no Brasil: Panorama Histórico, Político e Social
Authors: Dias Duarte Eduardo
Published: July 2024

A Educação de Jovens e Adultos (EJA) no Brasil é uma modalidade educacional com uma história marcada por desafios e avanços. Desde suas origens, tem sido uma ferramenta crucial para proporcionar oportunidades educacionais àqueles que não puderam concluir seus estudos na idade apropriada. Influências importantes, como as ideias de Paulo Freire, moldaram sua trajetória, destacando a importância da abordagem crítica e da valorização do conhecimento dos alunos. Apesar dos esforços e dos avanços, a EJA enfrenta diversos obstáculos, como a falta de políticas públicas adequadas e altas taxas de evasão escolar, muitas vezes atribuídas à necessidade de sustento das famílias. Para superar esses desafios, é essencial que o Estado implemente estratégias abrangentes e contínuas, desde a infância até a idade adulta, garantindo acesso igualitário à educação e promovendo a permanência dos alunos na escola. Além disso, é fundamental adaptar a metodologia educacional às necessidades e realidades dos alunos da EJA, reconhecendo suas experiências de vida e proporcionando um ambiente de aprendizado inclusivo e acolhedor. Somente por meio de um compromisso coletivo e investimentos significativos na educação poderemos verdadeiramente erradicar o analfabetismo e promover a transformação social em nossa sociedade.
Musicoterapia na doença de Parkinson
Authors: Couto Leticia Viana , Tavares Maria Clotilde Henriques
Published: July 2024

A doença de Parkinson é uma doença neurológica degenerativa que acomete cerca de 3% de pessoas acima de 60 anos no Brasil. Ela é caracterizada por sintomas motores (que incluem a bradicinesia, tremor de repouso e/ou rigidez com início assimétrico, e instabilidade postural) e múltiplos sintomas não motores. Uma das abordagens terapêuticas utilizadas para a redução dos sintomas da doença de Parkinson é a musicoterapia, visto que a música pode ajudar a recuperar funções no cérebro lesado ou afligido por doenças, como a doença de Parkinson. Diante disso, o presente estudo teve como objetivo fazer uma revisão de estudos que demonstram a utilização da musicoterapia como tratamento para a doença de Parkinson e seus efeitos. Foi realizada uma revisão sistemática com as palavras-chave “music therapy” e “Parkinson”, com a utilização do filtro para estudos publicados entre 2017 e 2023. Foram identificados 32 artigos, e após aplicação dos critérios de inclusão e exclusão, foram reduzidos a 12. Os resultados encontrados demonstraram uma grande eficiência na utilização da musicoterapia como tratamento para os sintomas da doença de Parkinson. Alguns estudos utilizaram a técnica da estimulação auditiva rítmica, devido à interação auditivo-motora (córtex auditivo e motor são recrutados na audição de música). Outros estudos tiveram seu foco em investigar os mecanismos neurológicos envolvidos no tratamento da marcha por meio da utilização da musicoterapia neurológica. Com base nos resultados encontrados, é possível concluir que a musicoterapia é uma abordagem adjuvante eficaz para o tratamento dos sintomas da doença de Parkinson.
Vantagens e desvantagens da supressão da puberdade em crianças e adolescentes com disforia de gênero
Authors: Silva Gabriel Corrêa da , Silva Levi Durães Batista da , Vieira Gabriel Sucupira , Festas Joana Pereira , Silva Ana Paula Alves da , Canuto Fernanda Vieira de Souza
Published: July 2024

A disforia de gênero (DG) é a incongruência entre o gênero de identificação e o sexo biológico do indivíduo. Indivíduos com DG podem apresentar sofrimento psíquico, devido ao surgimento das características sexuais secundárias do seu sexo biológico. A supressão da puberdade pode permitir ganho de tempo para considerações sobre a transição para o sexo de identificação e o fármaco utilizado é o agonista do hormônio liberador de gonadotrofina (GnRH). Esse trabalho é uma revisão de escopo da literatura acerca do assunto e visa compreender as vantagens e desvantagens do uso do agonista de GnRH em jovens com disforia de gênero. Foram encontrados 210 artigos nas bases de dados Pubmed-Medline, Scielo e LILACS, publicados de 2013 a 2023, em português e inglês, sendo excluídos 170 desses, por não cumprirem critérios metodológicos, ou apresentarem Escala de Newcastle-Ottawa baixa. Foram revisados 40 artigos que citaram tal abordagem terapêutica e apresentaram como principais vantagens a melhora da saúde mental com redução da ansiedade e depressão, dos comportamentos de automutilação e da ideação suicida, além da necessidade de menores doses hormonais na terapia hormonal cruzada posterior. As principais desvantagens descritas foram a redução na densidade mineral óssea, a diminuição estatural e o impacto da cirurgia de afirmação sexual de mulheres trans (necessitando por uma abordagem mais invasiva). Portanto, mesmo havendo pontos negativos, conclui-se que a abordagem de adolescentes com disforia de gênero com agonista de GnRH possui maiores benefícios do que a conduta observacional. Sobre o funcionamento cognitivo, novos estudos precisam ser analisados.
Suporte circulatório na disjunção aortoventricular
Authors: Souza Helmgton , Machado Henrique Louzan , Souza Beatriz Estrella , Santos Marcus Vinícius dos , Pina Glauco Kalil , Corso Ricardo Barros
Published: July 2024

Introdução: A disjunção aortoventricular é uma complicação rara e grave, relacionada, geralmente, às cirurgias da valva aórtica. Nessa condição, a utilização de suporte circulatório com ECMO (Oxigenação por Membrana Extracorpórea) pode estar recomendada. Devido à raridade e ao prognóstico, geralmente letal, existem ainda poucos trabalhos relatando essa complicação. Descrevemos um caso de disjunção aortoventricular em paciente submetido a reoperação da valva aórtica, tratado com sucesso por meio do emprego de ECMO. Relato do caso: Paciente de 66 anos, hipertenso, diabético, com histórico de correção de aneurisma de aorta ascendente há 5 anos, que evoluiu com disfunção de prótese valvar aórtica, sendo indicada a reoperação. A cirurgia foi realizada com auxílio de circulação extracorpórea (CEC). Após tentativa de saída de CEC observou-se sangramento em parede de ventrículo direito, sendo diagnosticada a disjunção aortoventricular. Após correção, constatou-se disfunção biventricular severa, confirmada por ecocardiograma transesofágico. Instalado balão intra-aórtico, e, na sequência, dispositivo de assistência circulatória com oxigenação por membrana extracorpórea (ECMO), na modalidade veno-arterial. Após sete dias de assistência circulatória optou-se pela substituição do dispositivo de assistência circulatória, o que foi programado para o 9o dia de suporte circulatório. À reabertura torácica, entretanto, observou-se recuperação da função biventricular, confirmada pelo ECO-TE. Foram realizados os testes de autonomia e retirada do suporte circulatório. O paciente permaneceu internado na UTI por 15 dias e recebeu alta hospitalar no 21o DPO. Conclusão: No caso apresentado, o uso de assistência circulatória veno-arterial (ECMO) permitiu a recuperação da função miocárdica após a correção cirúrgica da dissecção.
KEDUDUKAN OTONOMI DAERAH SEBAGAI PERAN DALAM PEMBANGUNAN EKONOMI
Authors: Adrian Hoirul Iqsan
Published: July 2024

Development is a process of growth and change for the better. All development is aimed at improving people's welfare. Economic development is an effort to increase a country's total income and per capita income by tracking population growth. This research method uses qualitative methods, which specifically analyze and describe the relationship between regional autonomy and economic growth in Indonesia. Regional autonomy plays an important role in economic development, with good and correct implementation, development can be achieved optimally. Therefore, regional development is expected to have a positive impact on economic growth.
Design and Implementation of SHMIOP Protocol for CORBA
Authors: Liu Hongyi
Published: July 2024

CORBA as a distributed object middleware application standard of the object management organization, the use of GIOP protocol makes cross-platform client-server object communication possible, and the use of shared memory combined with the GIOP protocol can improve the efficiency of transmission. In this paper, we propose a design method for a shared memory-based communication protocol, SHMIOP protocol, and test and verify it on e*ORB middleware.
Analyzing the Relationships of Psychological Symptoms in the SCL-90 Using Genetic Algorithms and Association Rule Mining
Authors: Wang Qiang , Yap Daisy S.
Published: July 2024

To improve the efficiency of processing SCL-90 data with association rules, this study integrates genetic algorithms with association rule mining techniques to analyze data from the SCL-90. The goal is to identify potential patterns and associations in psychological health issues. The SCL-90 is a widely used tool for assessing psychological symptoms and distress levels, consisting of 90 items that cover multiple dimensions such as obsessive-compulsive symptoms, anxiety, and depression. By employing genetic algorithms for preprocessing and optimizing the SCL-90 data, representative and distinctive feature subsets are selected. Genetic algorithms simulate the processes of natural selection, crossover, and mutation to identify optimal feature combinations, thereby enhancing the efficiency and effectiveness of association rule mining. The selected data is then analyzed using association rule mining techniques to generate rules with high support and confidence, revealing potential links between different psychological symptoms. The combination of genetic algorithms and association rule mining not only improves data processing and pattern discovery efficiency but also provides valuable insights for psychological health assessment and intervention.
Design and Implementation of Flexible Employment System Based on Uniapp
Authors: Xiong Fangge , Nan Chuxi
Published: July 2024

To help people achieve and do flexible employment, a system has been developed to provide and publish job and job search information and supervise the entire work process. The back end of the system uses the Springboot framework, the front end uses the Vue framework, and the MySQL database to develop a flexible employment system. The front-end of the system is the client; its main functions include publishing and searching job and job searching information, generating and evaluating orders, etc. The main function of the backend is to manage the data generated by the front end, such as managing user account information, user personal information, order information, etc. Flexible employment systems can allow users to achieve flexible job positions conveniently, improve the stability of flexible employment, and reduce social unemployment rates.
Optimized Modeling of Anti-Breast Cancer Drug Candidates
Authors: Sun Xiatian
Published: July 2024

Breast cancer is often referred to as the "Pink Killer", and its incidence rate ranks first among female malignant tumors. It has been found that the expression of estrogen receptors alpha (ERα) plays a very important role in breast lesions, and compounds that can antagonize the activity of ERα may be candidates for the treatment of breast cancer. In this paper, it is of practical significance to construct a quantitative structure-activity relationship (QSAR) model of compounds to screen potential compounds that can antagonize the activity of ERα by using a machine learning approach, and to construct a classification prediction model of ADMET properties to predict the pharmacokinetic properties and safety of compounds in the human body.
Research On Transmission Line Insulator Defect Detection Method Based on Yolov8
Authors: Yuan Chenning , Liu Yilin , Chen Xishi
Published: July 2024

Transmission line insulators are an important part of the power system, and their defects can seriously affect the safety and reliability of the power system. The traditional insulator defect detection method mainly relies on manual inspection, which is inefficient, costly, and easily affected by subjective factors. In order to improve the efficiency and accuracy of insulator defect detection, this paper proposes a YOLOv8-based insulator defect detection method for transmission lines. The method makes use of the powerful target detection capability of the YOLOv8 model to identify and locate transmission line insulator images and classify defect types. The experimental results show that the method achieves good results in insulator defect detection, can effectively identify and locate different types of insulator defects, and provides a reliable technical guarantee for the safe operation of transmission lines.
Current Status of Developing Cooperation Skills for 5-6 Years Old Children through Themed Role-playing Games at Trung Mon Kindergarten, Yen Son District, Tuyen Quang Province
Authors: Nhu Mai Nguyen
Published: July 2024

Educational scientists have affirmed that developing children's cooperation skills is one of the most important goals of preschool education. The preschool period is considered the golden period to form and develop cooperation skills. Collaborative skills education for 5-6 years old preschoolers can be done through many different ways. One of the favorable ways to form and develop is through themed role-playing games (TCĐĐTCT). Because TCDVTC carries all the basic features of games in a broad sense, it is full of children's emotions and passion, self-reliance and self-organization, positivity and creativity, cooperation, etc.
Hubungan Tingkat Anxiety Dengan Kebiasaan Bruxism Pada Mahasiswa Universitas Andalas
Authors: Syafitri Fuccy Utamy , Rahmi Eni , Putri Arifa Zahrani Elka
Published: July 2024

Anxiety merupakan faktor risiko utama untuk berbagai masalah kesehatan fisik dan mental. Mahasiswa lebih rentan mengalami anxiety dibandingkan populasi umum. Hal ini sering terjadi secara bersamaan dan dapat saling memperburuk sehingga menimbulkan berbagai keluhan dan berpengaruh pada fisiologis tubuh, salah satunya dapat menimbulkan kebiasaan bruxism. Penelitian ini bertujuan untuk mengetahui hubungan tingkat anxiety dengan kebiasaan bruxism pada mahasiswa Universitas Andalas. Jenis penelitian yang digunakan adalah observasional analitik dengan pendekatan cross sectional study. Analisis statistik yang digunakan yaitu uji Chi-square. Sampel penelitian dipilih 94 orang dengan teknik proportionate stratified random sampling. Pengukuran tingkat depresi, anxiety, dan stres dilakukan menggunakan kuesioner Anxiety, sedangkan penilaian bruxism menggunakan kuesioner modifikasi Daniel E. Paesani (Bruxism, Theory, and Practice) dan Winocur E (Self-reported bruxism association with perceived stress, motivation for control, dental anxiety and gagging). Penelitian ini menunjukkan bahwa prevalensi anxiety dengan tingkat keparahan yang berbeda-beda di antara responden yaitu anxiety (68.1%). Sebanyak 53 orang (56.4%) responden memiliki kebiasaan bruxism. Hasil uji statistik Chi-square didapatkan nilai p<0.05 yang berarti terdapat hubungan antara tingkat anxiety dengan kebiasaan bruxism pada mahasiswa Universitas Andalas. Terdapat hubungan antara tingkat anxiety dengan kebiasaan bruxism pada mahasiswa Andalas.
Impacto del desarrollo local en la salud comunitaria. Caso: sabanilla cantón Daule
Authors: Peraza de Aparicio Cruz Xiomara , Laines Mendoza Jenny Concepción
Published: July 2024

La visión del desarrollo local lleva implícito la movilización de los recursos del territorio en pro de un proyecto focal común que, involucra al conjunto de la población, relacionado este con el desarrollo integral donde las personas tengan las condiciones económicas necesarias para asegurarse su reproducción material; garantizado este elemento de vida y trabajo, de ingresos y capacidad de compra, resulta posible contar de manera sostenible con todos los satisfactores sociales necesarios para una vida humana digna. Por supuesto que dentro de estos satisfactores sociales esta la salud, considerada un derecho humano, la cual tiene su impacto en la satisfacción de necesidades de afecto, creación, participación y entendimiento. De ahí surge la necesidad de la armonía entre el hombre su medio ambiente y el desarrollo local, el cual no puede planearse sin considerar las consecuencias que este pudiera ocasionar en la afectación de la salud, siendo este el caso de la comunidad Sabanilla, donde se conjugan factores de contaminación ambiental, acuífera, sónica, entre otros, girando en torno al desarrollo de la explotación minera a cielo abierto.
L'attore in provetta. Johann Jakob Engel tra teoria dell’attore e sciences de l’homme
Authors: Matteini David ,   Università degli Studi di Siena
Published: July 2024

Se la traduzione francese delle Ideen zur Mimik (1785) del tedesco Johann Jakob Engel approfondisce una concezione dell’attore che, già a partire dalla seconda metà del secolo in Francia, si vede rinnovata grazie a importanti scritti teorici di letterati quali Luigi e François Riccoboni, Rémond de Sainte-Albine, Diderot, la centralità culturale del trattato risiede però anche nella messa in rilievo di una tendenza epistemologica che nel contesto del tardo Illuminismo franco-tedesco si stava imponendo non solo nell’ambito dell’estetica, ma anche in quello, più composito, delle cosiddette “scienze dell’uomo”. Il particolare interesse rivolto da Engel verso l’antropologia e i meccanismi neurologici dell’attore coinvolti nel rapporto emotivo con lo spettatore tradisce infatti una volontà indagatoria tesa, oltre che alla fondazione di una nuova arte della recitazione, soprattutto a una più completa comprensione delle riscoperte dinamiche cognitive dell’essere umano. In questo articolo cercherò di mettere dunque in evidenza, da una parte, l’apporto dato da differenti tradizioni pseudoscientifiche del periodo (il sensismo di Condillac, la fisiognomica di Lavater, il vitalismo di Diderot…) alla riflessione attoriale di Engel, e, dall’altra, lo statuto assunto da quest’ultima all’interno del fiorente milieu scientifico-antropologico della Francia di fine Settecento e inizio Ottocento.
PENGARUH PEMBERIAN BUAH PISANG MAS TERHADAP PENINGKATAN KADAR HB PADA IBU HAMIL TRIMESTER III DI PUSKESMAS KEMALO ABUNG KABUPATEN LAMPUNG UTARA
Authors: Melatri Nova Indah  , Iis Tri Utami
Published: July 2024

Anemia merupakan suatu keadaan adanya penurunan kadar hemoglobin, hematokrin dan jumlah eritrosit dibawah nilai normal. Prevalensi Anemia di Kabupaten Lampung Utara mengalami kenaikan dari 4028 kasus (26,8%) pada tahun 2017 mengalami kenaikan pada tahun 2018 sebanyak 4075 ( 27,5). Penelitian ini bertujuan untuk mengetahui Pengaruh Pemberian Buah Pisang Mas Terhadap Peningkatan Kadar Hb Pada Ibu Hamil Trimester III Di Puskesmas Kemalo Abung Kabupaten Lampung Utara Tahun 2020.
Metode Penelitian: Jenis penelitian yang digunakan quasi eksperimen dengan pendekatan Non Equivalent Control Group Design. Sampel dalam penelitian ini adalah ibu hamil trimester III yang Anemia Di Puskemas Kemalo Abung Kabupaten Lampung Utara yaitu 16 orang. Teknik pengambilan sampel penelitian ini dilakukan dengan menggunakan tehnik purposive sampling. Analisa univariat dan bivariat menggunakan uji t dependent.
Hasil penelitian: Rata rata kadar hb sebelum dilakukan pelakuan sebesar 9,750 gr/dl dengan standar deviasi 0,4897. Didapatkan mean rata rata kadar hb setelah dilakukan perlakuansebesar 11,27gr/dl dengan standar deviasi 0,384. Hasil analisis paired t-test didapatkan nilai p = 0,000 sehingga dapat disimpulkan pengaruh pemberian buah pisang mas tehadap kenaikan kadar Hb pada ibu hamil TM III di Puskesmas Kemalo Abung Lampung Utara tahun 2020. Berdasarkan hasil penelitian dapat disarankan kepada ibu hamil TM III untuk mengkonsumsi tablet Fe, dan Pisang Mas agar dapat meningkatkan Hb dalam tubuh pada masa kehamilan.
Explorando nuevos horizontes educativos, las TIC y su impacto en las prácticas de aprendizaje [Exploring new educational horizons, ICTs and their impact on learning practices]
Authors: Mejía-Salazar Gilberto
Published: July 2024

Las TIC están diseñadas para desarrollar habilidades clave, esto significa que el uso apropiado de la tecnología no sólo se centra en la transferencia de información, sino que también apunta al desarrollo de habilidades básicas de los estudiantes en la resolución de problemas y otras habilidades relacionadas con el desarrollo integral de los estudiantes. Este estudio tiene como objetivo analizar la transformación educativa integral mediante el uso de tecnologías, explorando prácticas de aprendizaje para optimizar la calidad educativa en estudiantes de nivel superior. Se adoptado una metodología cuantitativa. el 97.6% de los encuestados dijo que usa tecnología en la escuela, mientras que el 2.4% dijo que no usa tecnología. La preferencia generalizada por Google Chrome como navegador principal y el frecuente uso de computadoras para apoyar las actividades académicas enfatizan la centralidad de la tecnología en el día a día de los estudiantes.
Optimización de rentabilidad en empresas de arrendamiento comercial a través de gestión eficiente de costos [Optimising profitability in commercial leasing companies through efficient cost management]
Authors: Mullo-García Carlos David , Reyes-Cárdenas Narciza Azucena
Published: July 2024

Las empresas de arrendamiento se ven afectadas por la implementación de la Norma Internacional de Información Financiera 16 (NIIF 16), lo cual conlleva implicaciones contables, tributarias y financieras. Mientras que el objetivo consiste en analizar las metodologías de costeo y determinar la más apropiada para las empresas de servicios de arrendamiento en la ciudad de Quito - Ecuador como una herramienta de apoyo para la toma de decisiones estratégicas. Esta investigación se fundamentó en una metodología descriptiva, se optó por una perspectiva transversal. 70% de los encuestados informó que sus empresas utilizan alguna metodología de costeo. Los contratos de arrendamiento comercial deben contar con varios elementos fundamentales para ser efectivos y beneficiosos para ambas partes.
Contabilidad Financiera 4.0 y desafíos en las Instituciones de Educación Superior del Ecuador [Financial Accounting 4.0 and challenges in Higher Education Institutions in Ecuador]
Authors: Vintimilla-Padilla Cristina Estephania , Moreno-Narváez Verónica Paulina
Published: July 2024

La planificación tributaria se refiere a la búsqueda de métodos y alternativas legales para mitigar el impacto de los impuestos en empresas o individuos. Se tiene por objetivo de investigación analizar las estrategias de planificación fiscal para empresas del sector comercial en Ecuador. La investigación se centró en una perspectiva descriptiva con una finalidad transversal, abordando el tema en un único momento del tiempo. El 47% de las respuestas indican que los cambios han afectado de forma negativa a su empresa, mientras que solo alrededor del 36% señala un impacto positivo. La falta de familiaridad puede representar una barrera para optimizar la situación fiscal de las empresas, subrayando la importancia de mejorar el acceso a la información y la asesoría fiscal.
Inteligencias múltiples y el desarrollo de habilidades socioemocionales [Multiple intelligences and the development of socio-emotional skills]
Authors: Medina-Revelo Digna Cecilia , Medina-Revelo Mayra Tatiana , Medina-Revelo Ruby Geoconda
Published: July 2024

El desarrollo de inteligencias múltiples y habilidades socioemocionales en el currículo educativo puede tener un impacto sinérgico en el aprendizaje y el desarrollo personal de los estudiantes. Se presenta como objetivo analizar las inteligencias múltiples y el desarrollo de habilidades socioemocionales en el contexto educativo. De tipo descriptiva documental con un diseño bibliográfico, se seleccionaron 15 artículos de revistas especializadas. Aunque la teoría de las Inteligencias Múltiples (IM) suscita controversias respecto a su validez científica, su integración en el diseño curricular puede abrir puertas a enfoques educativos que fomenten un desarrollo personalizado y diversificado entre los estudiantes. En un mundo educativo en continua transformación, adoptar perspectivas críticas y empíricamente fundamentadas garantiza que las prácticas pedagógicas no solo sean innovadoras, sino también efectivas y pertinentes para preparar a los estudiantes para los desafíos del siglo XXI.