bluuebunny/crossref_metadata_2025 huggingface dataset:
Head and Neck Squamous Cell Carcinoma: Insights from Dual-Energy Computed Tomography (DECT)
Authors: Bicci Eleonora , Di Finizio Antonio , Calamandrei Leonardo , Treballi Francesca , Mungai Francesco , Tamburrini Stefania , Sica Giacomo , Nardi Cosimo , Bonasera Luigi , Miele Vittorio
Published: November 2024

Head and neck cancer represents the seventh most common neoplasm worldwide, with squamous cell carcinoma being the most represented histologic variant. The rising incidence of the neoplastic pathology of this district, coupled with the drastic changes in its epidemiology over the past decades, have posed significant challenges to physicians worldwide in terms of diagnosis, prognosis, and treatment. In order to meet these challenges, a considerable amount of effort has been spent by the authors of the recent literature to explore new technologies and their possible employment for the better diagnostic and prognostic definition of head and neck squamous cell carcinoma (HNSCC). Among these technologies, a growing interest has been gathering around the possible applications of dual-energy computed tomography (DECT) in head and neck pathology. Dual-energy computed tomography (DECT) utilizes two distinct X-ray energy spectra to obtain two datasets in a single scan, allowing for material differentiation based on unique attenuation profiles. DECT offers key benefits such as enhanced contrast resolution, reduced beam-hardening artifacts, and precise iodine quantification through monochromatic reconstructions. It also creates material decomposition images, like iodine maps, aiding in tumor characterization and therapy assessment. This paper aims to summarize recent findings on the use of DECT in HNSCC, providing a comprehensive overview to aid further research and exploration in the field.
SIRT1-Dependent Neuroprotection by Resveratrol in TOCP-Induced Spinal Cord Injury: Modulation of ER Stress and Autophagic Flux
Authors: Tian Xiangsheng , Ou Yiquan , Shi Shengyuan , Zhou Qiuhua , Long Sihong , Xiang Yao , Zhao Weichao , Long Dingxin
Published: November 2024

This study explores the neuroprotective effects of resveratrol (Resv) against tri-o-cresyl phosphate (TOCP)-induced neurotoxicity in the spinal cord of adult hens. It is well documented that TOCP exposure causes significant neurodegeneration via mechanisms that involve endoplasmic reticulum (ER) stress and impaired autophagy. In this experiment, adult hens were assigned to one of four groups: Control, Resv, TOCP, and TOCP + Resv. The spinal cord tissues were examined through transmission electron microscopy, hematoxylin and eosin (HE) staining, Nissl staining, and Western blotting to evaluate key proteins associated with ER stress and autophagy. Additionally, RT-qPCR and immunofluorescence were employed to measure sirtuin1 (SIRT1) expression. The findings revealed that TOCP induced severe ultrastructural damage, including disrupted myelin sheaths, dilated ER, and extensive neurodegeneration, as confirmed by histological evaluations. The expression levels of GRP78, p-PERK, p-eIF2α, ATF4, CHOP, Beclin-1, P62, and LC3-II were also significantly elevated by TOCP. However, Resv treatment markedly attenuated these pathological changes by reducing ER stress, restoring autophagic flux, and upregulating SIRT1 expression, preserving spinal cord integrity. These results indicate that Resv can effectively counteract TOCP-induced neurotoxicity by modulating ER stress and autophagy, underscoring its potential as a therapeutic agent for neuroprotection.
Evaluating the Efficacy and Safety of Botulinum Toxin in Treating Overactive Bladder in the Elderly: A Meta-Analysis with Trial Sequential Analysis of Randomized Controlled Trials
Authors: Chen Yu-Hsuan , Kuo Jen-Hao , Huang Yen-Ta , Lai Pei-Chun , Ou Yin-Chien , Lin Yu-Ching
Published: November 2024

Overactive bladder (OAB) significantly impairs quality of life in the elderly. Although the intradetrusor injection of botulinum toxin type A (BoNT-A) is a treatment option, its effects on older adults remain uncertain. This study aimed to evaluate the efficacy and safety of BoNT-A intradetrusor injections in elderly OAB patients through a systematic review and meta-analysis. A comprehensive literature search was conducted using the PubMed, Embase, Cochrane Library, Scopus, and CINAHL databases from inception to 30 May 2024. The primary outcomes were improvements in daily urinary incontinence (UI) episodes and patient-reported outcomes, while the secondary outcomes focused on potential adverse events. Four randomized controlled trials with 803 participants were included. BoNT-A injections significantly reduced daily UI episodes at 4–6 weeks (mean difference [MD]: −3.82; 95% confidence interval [CI]: −6.29 to −1.35) and at 12 weeks (MD: −2.17; 95% CI: −3.22 to −1.12). However, BoNT-A was associated with an increased risk of elevated post-void residual (Risk Difference [RD]: 0.154; 95% CI: 0.058 to 0.251) and urinary tract infection (RD: 0.111; 95% CI: 0.005 to 0.217), with no significant difference observed in the initiation of catheterization or hematuria. Trial sequential analysis confirmed a sufficient sample size and statistical power. In conclusion, while BoNT-A effectively manages OAB in the elderly, careful post-injection monitoring is warranted due to its potential risks.
Strengthening Tuberculosis Control Among Migrant Workers
Authors: Shrivastava Saurabh RamBihariLal , Bobhate Prateek Sudhakar , Petkar Prithvi Brahmanand , Mendhe Harshal Gajanan , Bandre Gulshan Ruprao
Published: November 2024

Tuberculosis (TB) is a serious infectious disease accounting for a significant number of deaths due to the infectious nature of the disease on the global platform. Migrant workers need special attention as these population groups live in substandard and crowded environmental conditions with poor ventilation, which play a crucial role in augmenting the risk of acquisition of infection. The global vision to ensure the delivery of effective TB control-related services for migrant workers has been influenced by a wide range of barriers. This issue is further complicated by the limited knowledge of migrant workers about tuberculosis, their rights, the kind of services available in healthcare facilities, and the ways to prevent the acquisition and transmission of infectious disease. By acknowledging the role of predisposing factors and the potential barriers that impact accessing timely healthcare services, it can be seen that the need of the hour is to plan and implement a comprehensive package of services for the benefit of migrant workers.
The Adeno-Associated Virus Replication Protein Rep78 Contains a Strictly C-Terminal Sequence Motif Conserved Across Dependoparvoviruses
Authors: Karlin David G.
Published: November 2024

Adeno-Associated Viruses (AAVs, genus Dependoparvovirus) are the leading gene therapy vector. Until recently, efforts to enhance their capacity for gene delivery had focused on their capsids. However, efforts are increasingly shifting towards improving the viral replication protein, Rep78. We discovered that Rep78 and its shorter isoform Rep52 contain a strictly C-terminal sequence motif, DDx3EQ, conserved in most dependoparvoviruses. The motif is highly negatively charged and devoid of prolines. Its wide conservation suggests that it is required for the life cycle of dependoparvoviruses. Despite its short length, the motif’s strictly C-terminal position has the potential to endow it with a high recognition specificity. A candidate target of the DDx3EQ motif might be the DNA-binding interface of the origin-binding domain of Rep78, which is highly positively charged. Published studies suggest that this motif is not required for recombinant AAV production, but that substitutions within it might improve production.
Antisera-Neutralizing Capacity of a Highly Evolved Type 2 Vaccine-Derived Poliovirus from an Immunodeficient Patient
Authors: Wu Yanan , Zhang Runfang , Yuan Guangbo , He Lingyu , Dai Xiaohu , Chuan Hongyun , Wang Mingqing , Liu Jing , Xu Lilan , Liao Guoyang , Li Weidong , Zhou Jian
Published: November 2024

Background: The serotype 2 oral poliovirus vaccine (OPV2) can revert to regain wild-type neurovirulence and spread, causing the emergence of vaccine-derived poliovirus (VDPV2) and immunodeficiency-related vaccine-derived polioviruses (iVDPVs). In the United States, testing carried out by the CDC of type II iVDPV (iVDPV2) with human immune serum from the vaccine has shown that the presence of the virus poses a threat to eradication efforts. Methods: We analyzed the major neutralization sites of VP1, VP2, and VP3 of the iVDPV using bioinformatics techniques and homology modeling (SWISS-MODEL). The three amino acid residues 679, 680, and 141 of the P1 region changed, which had an impact on the spatial conformation of the viral-neutralizing site. We tested polio-vaccinated human sera and rabbit anti-Sabin II polyantibodies against a panel of iVDPV pseudoviruses. Results: The results demonstrated that the serum’s capacity to neutralize mutant pseudoviruses diminished when amino acid substitutions were introduced into the P1 encapsidated protein, particularly when 141 and 679 were mutated together. This study emphasizes the significance of continually monitoring individuals who are known to be immunocompromised and maintaining high vaccination rates in OPV-using communities.
Design of a Glycoconjugate Vaccine Against Salmonella Paratyphi A
Authors: Alfini Renzo , Carducci Martina , Massai Luisa , De Simone Daniele , Mariti Marco , Rossi Omar , Rondini Simona , Micoli Francesca , Giannelli Carlo
Published: November 2024

Background/Objectives: Typhoid and paratyphoid fever together are responsible for millions of cases and thousands of deaths per year, most of which occur in children in South and Southeast Asia. While typhoid conjugate vaccines (TCVs) are licensed, no vaccines are currently available against S. Paratyphi A. Here we describe the design of a S. Paratyphi A conjugate. Methods: The serovar-specific O-antigen (O:2) was linked to the CRM197 carrier protein (O:2–CRM197) and a panel of conjugates differing for structural characteristics were compared in mice and rabbits. Results: We identified the O-antigen molecular size, polysaccharide to protein ratio, conjugate cross-linking, and O:2 O-acetylation level as critical quality attributes and identified optimal design for a more immunogenic vaccine. Conclusions: This work guides the development of the O:2–CRM197 conjugate to be combined with TCV in a bivalent formulation against enteric fever.
Optimal Timing for Intraocular Pressure Measurement Following Phacoemulsification Cataract Surgery: A Systematic Review and a Meta-Analysis
Authors: Herspiegel William J. , Yu Brian E. , Algodi Hamzah S. , Malvankar-Mehta Monali S. , Hutnik Cindy M. L.
Published: November 2024

Post-operative increases in intraocular pressure (IOP) are a frequent complication following phacoemulsification cataract surgery. Assessment of IOP is an essential element in post-operative checks. Despite this, guidance regarding the optimal timing remains vague. The purpose of this meta-analysis was to determine the current status of evidence that may help guide best practice regarding the optimal time following phacoemulsification cataract surgery to measure IOP. A comprehensive literature search was performed on MEDLINE and EMBASE. In two stages, independent reviewers screened articles that reported IOP measurements following uncomplicated cataract surgery. Risk of Bias Assessment was conducted following data extraction. The meta-analysis incorporated 57 randomized clinical studies involving a total of 6318 participants and 7089 eyes. Post-operative hour one had a significant decrease in IOP from baseline, while hour two had a non-significant increase. Post-operative hours four, six, and eight were the only timepoints to have a significant increase in IOP. Finally, post-operative day one had no significant change in IOP, while day two had a non-significant decrease. These results suggest that the optimal time to measure IOP is within the first 4–8 h following phacoemulsification cataract extraction. Taking measurements too soon or too late could result in missed IOP spikes.
Managed Aquifer Recharge for Sustainable Groundwater Management: New Developments, Challenges, and Future Prospects
Authors: Sufyan Muhammad , Martelli Grazia , Teatini Pietro , Cherubini Claudia , Goi Daniele
Published: November 2024

The combined effect of climate change and increased water demand has put significant strain on groundwater resources globally. Managed aquifer recharge (MAR) has become an effective approach for addressing groundwater depletion problems and sustainable management of groundwater resources. This review article provides an extensive insight into the existing knowledge of MAR, including the main objectives and applications, implementation techniques (surface spreading, sub-surface, and induced recharge) being practiced over the years, risks and challenges associated with the MAR, and the developments in the field of MAR. This review also explores the potential of MAR in the Friuli Venezia Giulia (FVG) region, north-eastern Italy. An average increase in temperature and a decrease in precipitation and piezometric levels in the region suggest the development of a proper MAR plan to manage water resources in the decades to come. Additionally, a comparative analysis of studies published over the last 20 years, focusing on the quantitative and qualitative aspects of water resource management, is conducted to analyze the research trends in the field of MAR. The reviewed literature reveals a notable research trend towards the quantitative aspect compared to the qualitative one. This review also identifies a notable disparity in qualitative studies during the analysis of water quality parameters considered in different MAR studies. Based on this review, a prospective viewpoint to address the challenges and expand the scope of the field is presented. This calls for an optimized strategy that considers both water quality and quantity issues, along with incorporating environmental and socio-economic aspects within the framework of MAR.
Influence of Physiographic Region on Pathogen Concentrations Between Stream Types
Authors: Bradley E. A. , Lockaby B. Graeme , Steury Todd , Madere Steven
Published: November 2024

Predicting public health risk associated with exposure to and recreational use of surface waters is often challenging due to substantial variability in concentrations of pathogenic bacteria, even among seemingly similar streams. In this study, we document significant differences in the surface water concentrations of the common bacteria indicators Escherichia coli and fecal coliform between two major stream types—blackwater and redwater streams (p < 0.001). We propose and present evidence that these findings result from natural biogeochemical variation between physiographic regions (p < 0.001). These findings suggest that physiographic stream type may influence the degree of exposure to waterborne pathogens and risk of waterborne disease. Future research is needed to assess whether the inclusion of stream type in risk assessments can improve public health modeling and mapping.
Removal of Phosphate from Water by Iron/Calcium Oxide-Modified Biochar: Removal Mechanisms and Adsorption Modeling
Authors: Zeng Shufang , Lan Xin , Liu Peng , Zhang Zhongxing , Cheng Xi , Xu Nuchao , Yin Huilin
Published: November 2024

Phosphorus (P) pollution is a leading cause of water eutrophication, and metal-modified biochar is an effective adsorbent with the ability to alter the migration capacity of phosphorus. This study uses bamboo as the raw material to prepare metal-modified biochar (ZFCO-BC) loaded with Fe and Ca under N2 conditions at 900 °C, and investigates its adsorption characteristics for phosphate. Batch experimental results show the adsorption capacity of the ZFCO-BC gradually increases (from 4.0 to 69.1 mg/g) as the initial phosphate concentration increases (from 2 to 900 mg/L), mainly through multilayer adsorption. Additionally, as the pH increases from 1 to 7, the adsorption capacity of the ZFCO-BC climbs to reach its maximum value of 48.4 mg/g with an initial phosphate concentration of 150 mg/L. At this pH, phosphate primarily exists as H2PO4− and HPO42−, which both readily react with Fe3+ and Ca2+ in the biochar. Furthermore, the addition of CO32−, HCO3−, NO3−, SO42−, F−, and Cl− each affect the removal rate of phosphate by less than 10%, indicating the ZFCO-BC has a highly efficient and selective phosphate adsorption capacity. A multi-column adsorption experiment designed to achieve long-term and efficient phosphorus removal treated 275.5 pore volumes (PVs) of water over 366 h. The cyclic adsorption–desorption experiment results show that 0.5 M NaOH can effectively leach phosphate from the ZFCO-BC. Observations at the molecular level from P K-edge XANES spectra confirm the removal of low-concentration phosphate is primarily dominated by electrostatic attraction, while the main removal mechanism for high-concentration phosphate is chemical precipitation. This study demonstrates that ZFCO-BC has broad application prospects for phosphate removal from wastewater and as a potential slow-release fertilizer in agriculture.
Water Supply Pipeline Failure Evaluation Model Based on Particle Swarm Optimization Neural Network
Authors: Zhang Lingchun , Jiang Haiming , Cao Hanyu , Cheng Rui , Zhang Junxi , Du Feixiang , Xie Kang
Published: November 2024

The degradation and failure of the urban water supply network may lead to serious safety hazards, including pipe breaks, water supply interruptions, water resource losses, and contaminant intrusions. The risk evaluation of water supply pipeline failure in a distribution network is a challenging task, because most of the available data cannot fully reflect pipeline failure events and many of the mechanisms still cannot be fully understood. Therefore, a predictive model is urgently needed to assess pipeline failure risk based on available data. In this paper, based on the traditional risk assessment theory, seven main factors affecting pipeline failure are selected and scored, and then a pipeline failure model is established by using the particle swarm optimization (PSO) neural network. The model uses the neural network training of historical data to evaluate the failure of the water supply pipeline, and the PSO is used to optimize the neural network to effectively improve the training time and accuracy. The model error and correlation coefficient are 0.003 and 0.987, respectively. The proposed model can be used as a powerful support tool to assist infrastructure managers and pipeline maintainers in their plans and decision-making.
Performance Analysis and Novel Cross-Flow Scheme of Low-Temperature Multi-Effect Distillation for Treating High-Mineralized Mine Water
Authors: Tang Yuanhui , Bai Yuanji , Guo Qiang , He Xiaolei , Li Mingxuan , Zhang Chunhui , Yu Lixin , Lin Yakai , Wang Xiaolin
Published: November 2024

Low-temperature multi-effect distillation (LT-MED) can be used to desalinate and demineralize highly mineralized mine water, facilitating the recycling and reuse of water resources. This study conducted a simulation of LT-MED technology for treating highly mineralized mine water using Aspen Plus and proposed a novel cross-flow optimization scheme. Initially, the impact of operational parameters such as process configuration, number of evaporation effects, and steam input on the gained output ratio (GOR) and scaling risk of a conventional LT-MED system was analyzed. It was found that the number of effects and heating steam flow rate had the most significant influence on GOR, while different processes exhibited limitations regarding GOR and scaling trends. To address these issues, this paper introduced a cross-flow operation process that combined forward, backward, and parallel flow. The simulation results indicated that, under conditions of eight effects, a maximum evaporation temperature of 70 °C, a temperature difference between adjacent effects of 4 °C, and a feed temperature of 45 °C, the cross-flow process—where the feed was introduced from the sixth effect—achieved the highest GOR and significantly reduced scaling risks compared to parallel and backward flow configurations. Finally, to further utilize low-pressure exhaust steam from the final effect of the cross-flow LT-MED system, mechanical vapor compression (MVC) and thermal vapor compression (TVC) were integrated into the LT-MED process. The thermodynamic performance of the coupled system was analyzed, and the simulations demonstrated that the coupled system outperformed the standalone use of either TVC or MVC, with the LT-MED-MVC-TVC system showing superior performance overall.
Waste Bauxite Residue Valorization as Trace Metal Sorbent: Application to Acid Mine Drainage Remediation
Authors: Gauthier Arnaud , Omana Brenda , Amin Fouad , Le Coustumer Philippe
Published: November 2024

With an output of more than two million tons of alumina per year, Venezuela is an important producer. As observed, this mining extraction activity generates a large number of by-products poorly valorized for many reasons (economic, technical, and due to environmental standards and regulations) Venezuela production generates wastes (more than 15 million of m3) called red muds, which are dumped in old lagoons near the Orinoco river or stored. This sludge has a high alkalinity (pH between 10 and 13) and a chemical composition containing some heavy metals (40 ppm Cr, 107 ppm La, 178 ppm Ce) that means it is considered environmentally problematic waste. However, their mineralogical, textural and structural characteristics make them adsorption materials. So, the aim of the study presented here was to investigate the sorption properties of these residues in the case of treatment of water from acid mine drainage. In fact, with an important reactive surface, their capacities to trap by adsorption trace elements such as cadmium, lead or zinc has been studied. Batch sorption tests revealed significant retention of contaminants such as Pb, Zn and As. These retention processes were interpreted using the Langmuir isotherm model. The promising first results indicate that the red mud named Venezuelan bauxite residue (VBR) reveals its great potential as a sorbent of inorganic pollutants. The sorption process is chemically dependent and efficient for certain pH and IS ranges. In addition, the material showed a strong affinity for the adsorption of arsenate (As5+). This was observed during post adsorption chemical speciation experiments, through the very high affinity of this element for the least mobile fractions, including oxyhydroxides mobile fractions, including Fe oxyhydroxides (amorphous). Nevertheless, these mining by-products could be considered as valuable absorbent materials. Despite this promising results, further studies are required to evaluate their potential in different conditions (dynamic tests, pH, IS, inorganic and organic contaminants, concentration and time effect).
Impacto da pandemia de COVID-19 nas funções orofaciais e comportamentos de sono
Authors: Tavares Ana Laura , Ribeiro Silva Stephanie , De Siqueira Cabral Amanda , Gomes Magalhães Raíssa , Régis Viana Giovanna , Santana de Araújo Nataly , Carvalho Silva Isabella , Picinato-Pirola Melissa
Published: November 2024

Introdução. Durante a pandemia de COVID-19, o distanciamento social e o isolamento foram essenciais para conter a transmissão do coronavírus. Estudos indicam que as alterações psicossociais estão relacionadas ao aumento de distúrbios psicológicos e hábitos orais prejudiciais, que se persistentes, afetam funções como fala, mastigação e respiração. Além disso, o isolamento social e as alterações psicossociais também afetaram os padrões de sono. Objetivo. Comparar achados relacionados à respiração, disfunção temporomandibular, mastigação e sono, antes e durante a pandemia da COVID-19. Método. Estudo observacional, transversal, quantitativo. Participaram 224 pessoas, entre 18 e 50 anos, que concordaram voluntariamente em responder um questionário online. A análise estatística foi realizada por meio do teste Cochran–Mantel–Haenszel e adotou-se significância de 5%. Resultados. O estudo analisou os impactos do isolamento social durante a pandemia de COVID-19 em diferentes aspectos da saúde, incluindo qualidade do sono, respiração, mastigação e disfunção temporomandibular. Os resultados indicam mudanças significantes nos padrões de sono, aumento na preferência por alimentos líquidos e pastosos, alterações nos padrões respiratórios e aumento de hábitos parafuncionais, porém, não houve diferença significante relacionada à apresentação de dor na articulação temporomandibular.  Conclusão. Conclui-se que devido ao período pandêmico, foram geradas mudanças no estilo de vida, hábitos e interações sociais, que afetaram diferentes esferas da saúde da população. Aspectos como respiração, disfunção temporomandibular, mastigação e sono sofreram diferentes impactos. Tais descobertas são relevantes para futuras pesquisas em saúde e para a atuação profissional, especialmente na Fonoaudiologia.
Evaluation of Door-to-Needle Stroke Patients With Thrombolytic Activation Code in Imam Reza Educational Center in Tabriz
Authors: Shams Vahdati Samad , Ala Alireza , Sadeghi-Hokmabadi Elyar , Ghasemi Hossein
Published: November 2024

Objectives: To investigate the therapeutic process and golden times for treating stroke patients receiving thrombolytic therapy at Imam Reza Hospital in Tabriz. Design: A cross-sectional descriptive study. Setting(s): The information for all patients entering the study was extracted from the stroke registry of the Neurosciences Research Center. Participants: Participants comprised all patients who were referred to Imam Reza Hospital emergency department (ED) in 2018, hospitalized as stroke patients, and had an indication for receiving thrombolytic therapy. Outcome measures: Data included demographic information, length of stay in the ED, time interval from the onset of symptom to ED arrival, time to CT scan, time to the start of thrombolytic therapy, outcomes (e.g., discharge, hospitalization, or death), and the use of tissue plasminogen activator (tPA) therapy. Results: A total of 140 patients were studied, with a mean and median age of 66.19±12.68 and 67.5 years, respectively. The mode age was 73 years, with the maximum age being 91 years and the minimum age being 34 years. Moreover, 82 (58.6%) of patients were male, and 58 (41.4%) were female. The mean time interval from ED arrival to the start of thrombolytic injection was 54.49±27.42 minutes, with a median and mode of 51 and 60 minutes, respectively. The minimum time was 17 minutes, and the maximum time was 218 minutes. The modified ranking scale (mRS) score at 7 days was significantly related to the National Institutes of Health Stroke Scale (NIHSS) at arrival, NIHSS 36 hours after treatment, NIHSS at 7 days after treatment, the incidence of intracerebral hemorrhage, and hospitalization duration (P≤0.001). Conclusions: Initiating thrombolytic injection within 60 minutes is feasible, and patients’ status 7 days after discharge has a significant relationship with NIHSS at arrival, NIHSS 36 hours post-treatment, and NIHSS 7 days post-treatment. Moreover, there is a significant correlation between mRS at 7 days and an interval of less than 60 minutes from ED arrival to the start of thrombolytic injection. In such cases, mRS is lower.
Online Evidence-Based Medicine Learning During the COVID-19 Era: Personal Experience in Two Online Autumn Schools
Authors: Sani Anis , Khalichi Rozhin , Beheshti Rasa , Dehghanzadeh Saba , Kabir-Saber Nadia , Kiani-Nasab Sepideh , Taraghikhah Maryam , Adabi Ali , Hassanzadeh Robab , Salehi-Pourmehr Hanieh , Hajebrahimi Sakineh
Published: November 2024

Background: The COVID-19 pandemic has disrupted the traditional educational system of schools and universities. Digital education has become the core method of learning during the pandemic. The objective of this study was to report our experience of a pilot online evidence-based medicine (EBM) school and review the opportunities and challenges coming along with online learning. Methods: The Iranian Student Center for EBM organized this online EBM course in two phases. The purpose of phase one was to familiarize participants with EBM basics, and phase two aimed to overview systematic review studies. The classes were accompanied by supplementary educational videos and practical group assignments. Participants were asked to complete a test evaluating their general knowledge of EBM and systematic reviews. Results: Overall, 29 students (10 men and 19 women) in the first phase and 51 students (24 males and 27 females) in the second phase from different universities and study fields (mostly medical fields) participated in this course. In the first and second phases, mean scores of 28.10 and 64.27, as well as 46.97 and 81.89 from 100, were obtained in the pre-test and post-test, respectively. Based on the analysis, test scores improved significantly after the course (P<0.001). Subgroup analysis regarding the gender of students showed no statistical difference between the two groups. Conclusion: Despite the challenges facing remote education during the COVID-19 outbreak, this online EBM school was effective for the participants. Technical problems and low student engagement levels were the main setbacks of online learning.
The Tea Utensils and Tea Culture Unearthed from Temples in the Jungwon region during the Goryeo Dynasty
Authors:   The hoseo Archaeological Society, Na Sangchul
Published: November 2024

The Jungwon region currently centers around Chungcheongbuk-do, and includes parts of Gyeonggi-do and Gangwon-do around the Namhan River. At the heart of the Jungwon region is the Namhan River, which unites the area. Particularly during the Goryeo Dynasty, the Namhan River served as a major transportation and shipping route. Many temples were situated along the river and in its vicinity, which played various roles including religious, political, public, and recreational functions. As these temples performed these diverse roles, the tea culture in the Jungwon region naturally flourished alongside.
However, the tea culture in the Jungwon region evolved more rapidly compared to other areas, due to its connection with the Namhan River as a transportation route and its close relationship with the Goryeo royal court. Initially, the Tang Dynasty’s “zha” tea preparation method was used, but from the mid-Goryeo period, the Song Dynasty’s “dian” tea preparation method was adopted, marking a significant shift in tea culture. This transition in tea culture can be confirmed through ceramics excavated from temples in the Jungwon region. The tea utensils founded in this region include celadon cups, celadon teapots, and celadon tea dishes, as well as numerous Chinese-made ceramics. Notably, the discovery of black-glazed bowls from the Jian kilns provides important evidence of the prevalence of the “dian” tea preparation method in the Jungwon region.
The development and transformation of tea culture in the Jungwon region can be interpreted as a result of the swift influx of Chinese culture through the Namhan River and its close relationship with the Goryeo royal court.
The Operation and Meanings of Baekje Kiln Sites in the Cheongyang Area
Authors:   The hoseo Archaeological Society, Lee Soleon
Published: November 2024

Evidence has confirmed the existence of kiln sites that produced a variety of objects in the Cheongyang area over different periods. They are so large in numbers that they account for approximately 42% of the entire relics. There were especially many kiln sites built in the Cheongyang area because of its geographical conditions necessary for production and its historical context close to the capital city.
All of the Baekje kiln sites were built in “Yeolgi-hyeon” and supplied necessary objects to the capital cities of Woongjin~Sabi. The kiln sites of Hagam-ri made and provided ceremonial pottery needed in the capital cities. Those of Gwanhyeon-ri and Wangjin-ri made and supplied roof-tiles representing each group. Those of Bonui-ri were characteristic in that they produced pedestals for Buddha statues.
The Baekje kiln sites in the Cheongyang area were managed in three major ways including the production of roof-tiles along with pottery, the changing supply-demand relations, and the intentional transformation of roof-end tiles patterns. They were the results of flexible responses to roof-tiles demand in the composition and moving of the production group and the efficiency of kiln operation.
Baekje built kiln sites in the Cheongyang area because the capital city lacked the conditions to build a production relic. The mountains around the capital city had tombs and fortresses built, and it was important to minimize the fire risk of the major buildings within the capital city walls.
The opposite side of the Geumgang-River was thus highlighted as an important production site, and the Cheongyang area followed this historical context.
Research Trends in Rights-Respecting Childcare in Daycare Centers Using Keyword Network Analysis
Authors:   Korean Society for  Holistic Convergence Education, Choi Hyunhee , Park Seonhye
Published: November 2024

This study aims to examine research trends by using the frequency and research methods of research on respect for rights in daycare centers and keyword network analysis. To this end, 111 domestic research papers registered in KCI from 2011 to 2024 were selected through a keyword search related to respect for rights childcare and analyzed by period. As a result, first, 88 studies were published in the second period (2018-March 2024), and quantitative research was the most common research method. Second, the keyword network analysis results showed that the keywords ‘respect for rights of infants and toddlers’, ‘respect for rights of infants and toddlers’, and ‘early childhood teachers’ appeared frequently in all periods. The centrality analysis results showed that ‘respect for rights of infants and toddlers’, ‘respect for rights of infants and toddlers’, and ‘early childhood teachers’ appeared in the top keywords in all periods, and ‘early childhood rights’ was ranked high in the first period, and ‘teacher professionalism’ and ‘organizational health’ were ranked high in the second period. Through the results of this study, we identified research trends in childcare rights-respecting childcare in daycare centers and derived the need for expanding the diversity of related research. It is significant in that it suggests future directions for strengthening teacher professionalism for childcare rights-respecting childcare in childcare settings.
La llamada «acumulación» emprendedora. El Estado emprendedor del Nuevo Neoliberalismo, siglo XXI
Authors:   Escuela Superior de Administración Pública, Colombia, Puello-Socarrás José Francisco
Published: November 2024

El emprendimiento como fórmula político-económica emergente es una de las «innovaciones» clave tanto en la teoría como en las praxis ideológicas neoliberales, desempeña un papel crucial en la evolución que caracteriza el capitalismo tardío en el siglo XXI. Lo anterior acompaña y profundiza los procesos de explotación económica, dominación política y opresión social, todos ellos exacerbados durante la fase neoliberal. Este artículo sintetiza algunos de los principales rasgos de este proceso, destaca los aspectos sustanciales de la teoría del emprendedor, sus orígenes e irrupciones subraya además las facetas fundamentales de la praxis emprendedora en el marco de la economía política contemporánea. A través de una ilustración sintética —el caso de la llamada Economía Naranja en Colombia— se ejemplifican los elementos que en términos concretos están convergiendo en las prácticas gubernamentales actualmente vigentes en lo que podríamos denominar alegóricamente: la acumulación emprendedora.
El capitalismo en crisis. La gestión del cambio tecnológico en el Quinto Kondratiev
Authors:   Universidad Nacional Autónoma de México, Rivera Ríos Miguel Ángel , Araujo Loredo Oscar Daniel , García Veiga Josué , Lujano López José Benjamín ,   Universidad Nacional Autónoma de México
Published: November 2024

El artículo presenta un análisis sobre la dinámica del capitalismo a largo plazo, al asociar las revoluciones industriales con la caída tendencial de la tasa de ganancia. Lo anterior con el fin de comprender la relación que guarda la crisis actual del capitalismo y el cambio tecnológico centrado en el paradigma tecnoeconómico digital. Al partir de que la productividad y el crecimiento económico mundial han ido declinando desde hace aproximadamente dos décadas se formula un análisis que incorpora el andamiaje socioinstitucional, el ciclo de poder global y las contradicciones inherentes del capitalismo que acumula más capital del que puede absorber. Se logra, así, una visión interpretativa que subraya la potencialidad del pasaje a la inteligencia artificial, mediada por un acuerdo entre las dos superpotencias mundiales que, de tener éxito, abrirán un capítulo nuevo en la historia de la humanidad en el que quedará superado socialmente el poder del capital.
Escola de Psicologia Social Comunitária da Universidade de São Paulo (1970-2020)
Authors: Costa José Fernando Andrade
Published: November 2024

Revisitamos a história da Psicologia Social Comunitária (PSC) no Brasil e analisamos a ausência de menções aos trabalhos produzidos pela Universidade de São Paulo (USP). Partindo da pesquisa histórica com fontes bibliográficas, buscamos responder à seguinte pergunta: qual a contribuição da USP para o campo da PSC brasileira? Os resultados mostraram que existe o desenvolvimento de uma “escola uspiana”, no Campus do Butantã, desde a década de 1970. Identificamos três períodos, ou gerações de pesquisadoras(es) (1970-1990, 1990-2010 e 2010-atual), e apontamos conceitos próprios ou desenvolvidos por essa tradição, tais como: comunidade de destino, enraizamento, humilhação social, cenas sociais e vulnerabilidades pessoal, social e programática. Concluímos que a escola uspiana vem se consolidando no campo da PSC e, devido sua larga tradição, tem oferecido contribuições significativas para a disciplina, ainda que pouco notada pela literatura disponível.
Marketing Verde, Responsabilidad Social y Composición Empresarial
Authors:   Universidad Santiago de Cali, Escobar Cabrera Julio César , Gómez Racines Ligia ,   Universidad Santiago de Cali
Published: November 2024

Este libro contiene los resultados de investigaciones en su mayoría cofinanciadas por la Universidad Santiago de Cali en convocatorias, y realizadas por profesores vinculados a los grupos de investigación del Centro de Estudios e Investigaciones en Desarrollo Regional CEIDER de la Facultad de Ciencias Económicas y Empresariales, en trabajo colaborativo con investigadores de otras entidades y con estudiantes de nuestros programas de pregrado y postgrado de Cali. En el libro se desarrollan temas como marketing verde, composición empresarial, responsabilidad social empresarial y gestión ambiental. En el primer capítulo se presenta el marketing verde como estrategia de promoción de la responsabilidad social empresarial. En el segundo capítulo se presenta la percepción de los clientes de una empresa sobre sus productos como parte de una investigación de mercado. En el tercer capítulo se presenta un análisis de la composición empresarial del municipio de Palmira en el período 2013-2016. En el cuarto capítulo se presentan los limitantes de la responsabilidad social en algunos ingenios del Valle del Cauca. En el quinto capítulo se presenta un estudio sobre la exportación para la comercialización de la uchuva (Physalis peruvian) en el mercado de Karlsruhe en Alemania y en el sexto capítulo se presenta la percepción que sobre el cambio climático tienen los estudiantes de la Facultad de Ciencias Económicas y Empresariales de nuestra Universidad.
PARÁMETROS QUE DELIMITAN LA RESPONSABILIDAD SOCIAL AMBIENTAL EN LOS INGENIOS DEL VALLE DEL CAUCA
Authors:   Universidad Santiago de Cali, Ríos Obando José Fabián , Angarita de la Cruz Bernardo ,   Corporación Universitaria Centro Superior, Romero Palacios Wilson Eduardo ,   Corporación Universitaria Centro Superior
Published: November 2024

La evidencia de elementos de Responsabilidad Ambiental Empresarial, en modelos de gerencia administrativa, ofrece caminos estratégicos para la competitividad y sostenibilidad en el mercado de las micros y pequeñas empresas, tanto del sector productivo, como del comercial y de servicios, toda vez que, en los trazos hacia la disminución del impacto ambiental, estamos sujetos a su participación.
¡Superyó! Un superhéroe en casa, aprendiendo a través de divertidas misiones
Authors:   Pontificia Universidad Javeriana, Gálvez Vallecilla Paola Andrea
Published: November 2024

A través del presente documento se presenta una propuesta pedagógica que tiene como objetivo responder a la situación que atraviesa la educación colombiana en los niveles de educación inicial y básica primaria debido a la situación de emergencia sanitaria ocasionada por el COVID 19. La propuesta se concibe como una estrategia flexible que permite la vinculación del contexto familiar y la cultura del educando en las actividades que se proponen, donde el estudiante es el centro del proceso de aprendizaje; además, contempla un eje articulador estructurado desde los intereses de los niños que fomenta la motivación y la autonomía. Inicialmente, se elaboró la estrategia pensando en el contexto del municipio de Jamundí, pero al estar estructurada, se observa que puede ser aplicada desde diferentes regiones del país. La propuesta pedagógica hace parte de una hermosa iniciativa denominada Zarzo, Tejido de saberes, el apartado es canciones y juegos de arcoíris. Se encuentra en el siguiente enlace: https://sinergiaeducativa20.wixsite.com/zarzo.
La intervención psicológica a pacientes hospitalizados por quemaduras: la pregunta por la vida que sigue después de la quemadura
Authors:   Universidad Libre, Obando Cabezas Lucely
Published: November 2024

Este texto corresponde a una revisión de literatura sobre la intervención psicológica en pacientes quemados en servicios hospitalarios, durante la fase preoperatoria, postoperatoria y de recuperación ex-terna al servicio. El texto identifica, teniendo en cuenta la literatura que hay sobre el tema, el valor que le conceden a los factores que inci-den en la salud mental de los pacientes, los aspectos diferenciales de cada propuesta de intervención, la importancia de los tratamientos farmacológicos, así como a las discusiones de carácter interdisciplinar para proponer nuevos modelos de intervención clínica que sean más pertinentes y efectivos.
PAGYVENUSIŲ PACIENTŲ REAKCIJOS Į APLINKOS STRESĄ
Authors: Valiulienė Žaneta , Stalnionienė Loreta , Druteikaitė Ieva
Published: November 2024

Aplinkos stresoriai gali turėti įvairių neigiamų padarinių pagyvenusiems pacientams, įskaitant fizinės sveikatos sutrikimus, psichologinius sunkumus ir socialinę izolia­ciją. Tai gali padidinti jų jau esamas sveikatos problemas arba sukelti naujų. Pagyvenusiems pacientams svarbu gauti atitinkamą paramą ir palaikymą, siekiant suma­žinti šį neigiamą poveikį. Pandemija ir karas Ukrainoje iškėlė iššūkius visam pasauliui, sukėlė nežinomybę ir baimę tarp žmonių, tačiau vyresnio ir pagyvenusio am­žiaus asmenys atsidūrė didžiausios rizikos grupėje, ku­riems COVID-19 kelia didžiausią pavojų ir mirtingumą. Problema yra ta, kad pandemijos laikotarpiu, dėl suke­liamo streso ir nerimo, kyla papildomi iššūkiai vyresnio amžiaus asmenų sveikatai ir jų gyvenimams – žalingai veikiama psichoemocinė būsena, psichinė sveikata ir net gretutinės ligos. Tyrimo tikslas – išanalizuoti pa­gyvenusių pacientų reakcijas į aplinkos stresą. Atliktas kiekybinis tyrimas X ligoninės palaikomojo gydymo ir slaugos skyriaus padalinyje. Darbo autorių buvo suda­ryta anketa. Tyrimas atliktas 2023 m. birželio – 2024 m. balandžio mėn., dalyvavo 150 respondentų, slaugomų X institucijoje. Dauguma respondentų nurodė, jog dažnai stresas susijęs su TV laidomis ir karu Ukrainoje. Daž­nai stresas susijęs su informacijos srautu, kuris tampa nepakeliamas. Pusė respondentų nurodė, kad informaci­jos srautas socialiniuose tinkluose tampa nepakeliamas. Įvertinus respondentų nuomonę, dauguma nurodė, kad labai dažnai pasaulinė pandemija COVID-19 sustiprino baimę ir įtampą. Dauguma respondentų (68 %) nurodė, kad spaudos informacija nėra susijusi su stresu.
EYELID CHONDROID SYRINGOMA: UNVEILING A RARE EYELID TUMOR
Authors: Gondhali Gayatri Rajendra , Krishnamurthy Rahul
Published: November 2024

Chondroid syringoma is a rare, benign mixed tumor featuring sweat gland elements within a cartilaginous stroma. It predominantly affects middleaged adults and is usually found in the head and neck region. Its occurrence in the eyelid is exceedingly rare. We report the case of a eighteen-yearsold female with a slow-growing painless mass in the left lower eyelid over five years. Her rest ocular examination was within normal limits. Mass
was successfully excised surgically under local anesthesia. Histopathological examination confirmed the diagnosis of chondroid syringoma. This
case highlights the importance of recognizing this rare tumor in the differential diagnosis of eyelid lesions and emphasizes the necessity of
complete excision to prevent recurrence or malignant transformation.
A STUDY OF COAGULATION PROFILE IN CANCER PATIENTS AT A TERTIARY CARE HOSPITAL IN INDIA
Authors: Kaur Harleen , Kaur Harpreet , Singh Jaspreet , Devgan Rajiv , Bagga Permeet Kaur , Singh Tejasvin
Published: November 2024

There is considerable evidence that thrombosis is a common complication of malignancy and represents the second most frequent cause of death in
cancer patients. Clinically detectable venous thromboembolism (VTE) is present in 15% of all cancer patients and the number is likely to be higher
when subclinical thromboembolism is taken into account. The present study was done to determine prevalence of coagulopathy in 100
histopathologically diagnosed cancer patients and to study the correlation between various types of cancers and thrombosis. A statistically
signicant correlation was found between various cancer types and APTT, which helps to understand the complex relationship between cancer and
coagulation disorders and to develop optimal strategies for preventing and managing thrombosis in cancer patients.
OUR EXPERIENCE WITH DUPUYTREN'S CONTRACTURE AND PATIENTS PERSPECTIVES USING THE MICHIGAN HAND QUESTIONNAIRE
Authors: Bhagwatrao Patil Surendrakumar , Nilesh Kadakia Khushboo , Gupta Neha , Suhasrao Barai Varsha , Sudarshan Doshi Sukhen , Gandhi Anshoo
Published: November 2024

Background: Dupuytren's disease is a benign proliferative disease of the palmar and digital fascia. Patients with severe contracture and functional
disability are operative candidates. Most common treatment modalities employed are regional fasciectomy or dermato fasciectomy. As this disease
is relatively uncommon in India, our purpose is to study the disease severity, its underlying associations, and the outcomes after surgery. Methods:
A study was done on 46 patients over the last 17 years who presented to our institute. All patients underwent regional fasciectomy or dermato
fasciectomy for the deformity and were followed up for a period of 2 years. Michigan Hand Questionnaire scores were calculated for each patient in
pre-operative and 6 months post-operative period. Results: Out of the 46 patients operated, 52.17% patients had bilateral hand involvement,
36.95% patients had involvement of right hand exclusively while only 10.86% patients had involvement of left hand alone. 41.3% of the patients
whose right hand was operated on belonged to Tubiana Stage 3. Regional fasciectomy with/without grafting was done in 52.17% patients whereas
dermato fasciectomy with grafting was done in remaining 47.82% patients. Recurrence was seen in 6.52% of the patients. The Michigan Hand
Questionnaire calculated at 6 months showed 20-40% improvement in all stages of Tubiana and maximum improvement was seen with Aesthetics
scale. The operative outcome, complications and recurrence rates are comparable to other published s Conclusion: tudies. Regional fasciectomy
has proved to be safe and effective in all stages of Tubiana classification.