bluuebunny/crossref_metadata_2025 huggingface dataset:
„Enhanced recovery after surgery” bevezetése a vastagbél sebészetében
Authors: Bánky Balázs , Lakatos Miklós , Varga Krisztina , Hansági Edit , Horváth Éva , Járay Géza
Published: March 2018

Absztrakt:

Bevezetés: A colorectalis betegek perioperatív kezelésében
mintegy 20 éve új multidiszciplináris gyakorlat jelent meg, az úgynevezett
„gyorsított felépülést segítő program”, angol terminológiával az „Enhanced
Recovery After Surgery (ERAS)”. Az ERAS evidencián alapuló tevékenységsor, amely
a laparoscopos műtéti technikával összekapcsolva a posztoperatív morbiditási
mutatók javulását, a kórházi tartózkodás csökkenését és költséghatékony ellátást
tesz lehetővé. Célkitűzés: A tatabányai megyei kórház Sebészeti
Osztályán 2013-tól vezettük be a laparoscopia mellett az ERAS protokollt. A
2015–2016-os két év vonatkozásában a „hagyományos” és az ERAS szerint vezetett
colorectalis perioperatív kezelési módszert hasonlítottuk össze. Betegek
és módszerek: Retrospektív, egy centrumban végzett klinikai
vizsgálatban a két, demográfiai és betegségjellemzők szerinti homogén
betegcsoport kórházi tartózkodási idejét, a posztoperatív morbiditást,
mortalitást, valamint a korai funkcionális eredményeket elemeztük.
Eredmények: 130 beteget kezeltünk hagyományos, 84 beteget
ERAS protokoll szerint. Az átlagos kórházi tartózkodási idő 8 és 6 nap (median)
volt. A korai osztályos visszavételi arány az ERAS csoportban nem mutatkozott
magasabbnak (3,1% és 1,2%). Posztoperatív morbiditásban az ERAS protokollt
találtuk kedvezőbbnek (27,4% hagyományos, 8,3% ERAS), hasonlóan a mortalitási
mutatók is enyhe javulást mutattak. Következtetések: Az ERAS
protokoll sikeres bevezetéséről számolunk be egy megyei kórház gyakorlatában. A
kedvező tapasztalatok alapján a 2017-es évtől egységes protokollként az ERAS-t
minden egyes elektív colorectalis műtétes beteg esetére kiterjesztettük.
Appleby-műtét − lehetőség truncus coeliacust infiltráló pancreastest tumor sebészi kezelésére
Authors: Kelemen Dezső , Lőcsei Zoltán , Papp Róbert , Ferencz Sándor , Vereczkei András
Published: March 2018

Absztrakt:

Esetismertetés: Esetünkben neoadjuváns onkológiai kezelést
követően egy olyan pancreas baloldali tumor sebészi eltávolítását ismertettük,
ami infiltrálta a truncus coeliacus oszlást és a gyomort is. A beavatkozás során
a truncust resecáltuk, distalis pancreatectomiát, splenectomiát, total
gastrectomiát, bal mellékvese-resectiót és cholecystectomiát végeztünk. Betegünk
zavartalanul gyógyult, csupán átmeneti májfunkciós laboreltérést tapasztaltunk.
A histologiai feldolgozás R1 resectiót mutatott, ezért adjuváns onkológiai
kezelésre kerül sor. Megbeszélés: A pancreas distalis tumorai
gyakran inoperábilisak. Ilyennek számított sokáig a truncus coeliacus oszlását
involváló elváltozás is, azonban van lehetőség radikális műtétre a truncus
resectiójával, ami után a máj artériás vérellátását a pancreaticoduodenalis
árkád biztosítja. Egy esetünk kapcsán ismertettük a műtéti technikát és az ezzel
kapcsolatosan felmerülő kérdéseket. Artériás infiltrációt mutató pancreastumor
esetén feltétlenül ajánlott a preoperatív kemoterápia, mivel megfelelő válasz
esetén van esély a daganat radikális eltávolítására.
PENGEMBANGAN VARIABEL-VARIABEL INDEKS KEPEKAAN EKOLOGI (IKE) BAGI PENGENDALIAN TUMPAHAN MINYAK DI EKOSISTEM MANGROVE
Authors: Muarif Muarif , Damar Ario , Hariyadi Sigid , Sutrisno Dewayani , Boer Mennofatria
Published: March 2018

Ketepatan suatu indeks dalam menggambarkan kondisi lingkungan sangat ditentukan oleh ketepatan dalam memilih  variabel-variabel pembentuknya.  Survei pakar internasional telah dilakukan untuk menilai validitas variabel-variabel terpilih dari indeks kepekaan ekologi (IKE) ekosistem mangrove terhadap tumpahan minyak.  Variabel-variabel IKE ekosistem mangrove hasil studi literatur dan telah disaring melalui survei pakar internasional adalah sebanyak 26 variabel yang meliputi tipe pasut, rentang pasut, tinggi gelombang, curah hujan, jumlah hari hujan, lama penggenangan pasang, jenis substrat, tipologi mangrove, jenis mangrove, umur flora mangrove, jumlah jenis mangrove, keberadaan flora invasif, kerapatan pohon, kerapatan anakan, kerapatan semai, perbandingan anakan dan pohon, kondisi ekosistem mangrove, jenis fauna, umur fauna, kemampuan gerak fauna, ruang hidup fauna, keberadaan flora mangrove dilindungi, keberadan fauna dilindungi, keberadaan nurshery habitat, keberadaan spawning ground, dan status lindung ekosistem mangrove.  Variabel-variabel tersebut mampu mewakili 6 karakteristik ekosistem mangrove. Variabel-variabel yang memiliki rangking yang tertinggi adalah variabel keberadaan nurshery habitat, sedangkan variabel yang memiliki rangking terendah adalah keberadaan flora invasif.  Variabel-variabel IKE ekosistem mangrove telah diujicoba di Pesisir Kabupaten Indramayu, dan mendapatkan sebaran IKE ekosistem mangrove tergolong mulai cukup peka sampai peka, dengan sebagian besar tergolong peka.
PERANCANGAN SISTEM INFORMASI ELEKTRONIK LOG BOOK PENANGKAPAN IKAN BERBASIS WEB
Authors: Nugroho Hadhi , Darmawan Adi , Sufyan Agus
Published: March 2018

Pusat Pengkajian dan Perekayasaan Teknologi Kelautan dan Perikanan (P3TKP) - Kementerian Kelautan dan Perikanan (KKP) telah mengembangkan teknologi elektronik log book penangkapan ikan berbasis GPRS. Elektronik log book merupakan perangkat keras yang memiliki fungsi utama untuk input data tangkapan ikan secara elektronik. Untuk menampilkan data elektronik log book menjadi informasi statistik secara real time, diperlukan sebuah sistem informasi berbasis web. Tahapan perancangan sistem informasi elektronik log book penangkapan ikan berbasis web terdiri dari identifikasi kebutuhan sistem, perancangan perangkat lunak, dan implementasi. Perancangan desain sistem database elektronik log book menggunakan MySQL. Desain sistem database tersebut berisi Conceptual Data Model (CDM) dan Physical Data Model (PDM). Untuk menggambarkan interaksi pengguna dengan sistem informasi elektronik log book dapat dilihat pada Data Flow Diagram (DFD). DFD pada perancangan sistem informasi elektronik log book terdiri dari DFD level-0, DFD level-1, dan DFD level-2. Modul-modul pada sistem informasi elektronik log book terdiri dari modul autentifikasi, modul data tangkapan, modul informasi harga ikan, dan modul informasi cuaca. Aplikasi kemudian diimplementasikan di domain www.p3tkp-elogbook.net. Sistem informasi elektronik log book penangkapan ikan berbasis web yang diaplikasikan ini dapat memberikan informasi secara cepat dan tepat tentang data penangkapan ikan, informasi harga ikan, dan informasi cuaca perairan, dengan kerahasiaan data yang terjamin.
STUDI KARAKTERISTIK HIDRODINAMIKA KAPAL IKAN TRADISIONAL DI PERAIRAN PUGER JEMBER
Authors: Indria Dwi Puspita Hery , Aria Pria Utama I Ketut
Published: March 2018

Secara umum, kapal ikan tradisional digunakan oleh nelayan di Indonesia dalam berlayar untuk menangkap ikan terutama nelayan di Kecamatan Puger, Jember. Pengrajin kapal ikan tradisional di Puger pada dasarnya hanya memodifikasi dari desain kapal sebelumnya dengan dasar keterampilan yang didapatkan dari turun-temurun pendahulunya. Karena kapal ikan tradisional di Puger tidak melalui proses formal dalam pembangunan kapal, maka diperlukan studi karakteristik hidrodinamika kapal ikan tradisional. Studi karakteristik hidrodinamika kapal ikan tradisional ini bertujuan untuk mengetahui kemampuan kapal bertahan dalam kondisi berbahaya saat beroperasi. Metode yang digunakan adalah dengan mengukur secara langsung dimensi utama dan mengukur bentuk body dari tiga kapal ikan tradisional di perairan Puger Jember. Selanjutnya hasil pengukuran tersebut digambar kembali, dan kemudian dilakukan evaluasi resistance dan seakeeping kapal ikan tradisional Puger Jember. Berdasarkan hasil evaluasi resistance dengan berbagai variasi kecepatan, kapal ikan tradisional di Puger Jember dengan lambung berbentuk lebih gemuk memiliki resistance yang lebih besar. Kemudian, dari evaluasi seakeeping ketiga kapal memiliki kriteria gerakan heave, pitch, dan roll yang berbeda-beda sesuai dengan bentuk body kapal.
PENGEMBANGAN INSTRUMEN LAGRANGIAN GPS DRIFTER COMBINED (GERNED) UNTUK OBSERVASI LAUT
Authors: Purba Noir Primadona , A. Harahap Syawaludin , Prihadi Donny J. , Faizal Ibnu , Mulyani Putri G. , Fitriadi Candra A. , Pangestu Isnan F. , Atmoko Prio D. , Alfath Adam , Sitio Joshua T.
Published: March 2018

Instrumen Lagrangian telah banyak digunakan untuk pengumpulan data arus laut dan observasi di perairan Indonesia membutuhkan data yang langsung dapat diketahui (real time). Kajian ini menekankan pada pengembangan GPS Drifter Combined (GERNED) dari sisi desain dan sistem pengukuran. Hasil pengujian menunjukkan bahwa GERNED dapat digunakan di danau, perairan dangkal, dan laut terbuka. Konstruksi terdiri dari bahan akrilik, Polyethylene, dan aluminium. Desain konstruksi terdiri dari bagian atas sebagai penutup dan juga tempat sensor udara dan lampu indikator, bagian tengah yang merupakan pusat mikro-kontroller, catu daya, sensor-sensor, penyimpanan data manual dan pengiriman data via satelit. Biaya yang dibutuhkan untuk membuat alat ini sekitar 15.000.000 (lima belas juta rupiah) dengan biaya terbesar adalah kontrol pengiriman data. Pada bagian bawah merupakan baling-baling statik. Pengujian yang dilakukan di laboratorium untuk melihat posisi lokasi sudah menunjukkan data yang sama dengan data lapangan sedangkan untuk pengujian lapangan yang dilakukan di pulau Untung Jawa menunjukkan bahwa arah dan pergerakan GERNED sama dengan pergerakan float tracking umumnya.
Microcephaly caused by congenital Zika virus infection and viral detection in maternal urine during pregnancy
Authors: Regadas Vanessa Couras , Silva Márcio de Castro e , Abud Lucas Giansante , Labadessa Luiz Mario Pereira Lopes , Oliveira Rafael Gouvêa Gomes de , Miyake Cecília Hissae , Queiroz Rodolfo Mendes
Published: March 2018

Summary Currently Latin America is undergoing a major epidemic of Zika virus, which is transmitted by Aedes mosquitoes. Concern for Zika virus infection has been increasing as it is suspected of causing brain defects in newborns such as microcephaly and, more recently, potential neurological and autoimmune complications including Guillian-Barré syndrome and acute disseminated encephalomyelitis. We describe a case of virus infection in a 25-year-old woman during the first trimester of her pregnancy, confirmed by laboratory tests only for the detection of viral particles in maternal urine, with imaging studies demonstrating the progression of cranial and encephalic changes in the fetus and later in the newborn, such as head circumference reduction, cerebral calcifications and ventriculomegaly.
Endobronchial carcinoid tumor: Radiological findings of a clinical case
Authors: Queiroz Rodolfo Mendes , Santana Danilo Brotto Ferreira de , Nastri Filho Rogério , Landell Gláucia Aparecida Magnani , Félix Paulo Roberto , Valentin Marcus Vinícius Nascimento
Published: March 2018

Summary We describe the case of a female patient, 21 years old, complaining of dyspnea attacks and wheezing 2 years ago. Chest radiography showed volume loss in the left lower lobe and ipsilateral retrocardiac triangular basal opacity. CT scan showed an extensive solid mass with apex protruding into the left main and lower lobar bronchi, causing distal atelectasis. Histopathological and immunohistochemical study of transbronchial biopsy of the lesion revealed a typical carcinoid tumor, confirmed after tumor resection with total left pneumectomy.
Impact of mechanical ventilation on quality of life and functional status after ICU discharge: A cross-sectional study
Authors: Vesz Patrini Silveira , Cremonese Rafael Viegas , Rosa Regis Goulart , Maccari Juçara Gasparetto , Teixeira Cassiano
Published: March 2018

Summary Objective: To evaluate the impact of the need for mechanical ventilation (MV) and its duration throughout ICU stay on the quality of life (QoL) and physical functional status (PFS) after the immediate ICU discharge. Method: This was a cross-sectional study including all subjects consecutively discharged from the ICU during 1-year period. During the first week after ICU discharge, QoL was assessed through WHOQoL-Bref questionnaire and PFS through the Karnofsky Performance Status and modified-Barthel index, and retrospectively compared with the pre-admission status (variation [Δ] of indexes). Results: During the study, 160 subjects met the inclusion criteria. Subjects receiving MV presented PFS impairment (Δ Karnofsky Performance Status [-19.7 ± 20.0 vs. -14.9 ± 18.2; p=0.04] and Δ modified-Barthel index [-17.4 ± 12.8 vs. -13.2 ± 12.9; p=0.05]) compared with those who did not receive MV. Duration of MV was a good predictor of PFS (Δ Karnofsky Performance Status [-14.6-1.12 * total days of MV; p=0.01] and Δ modified-Barthel index [-14.2-0.74 * total days of MV; p=0.01]). QoL, assessed by WHOQoL-Bref, showed no difference between groups (14.0 ± 1.8 vs. 14.5 ± 1.9; p=0.14), and the duration of MV did not influence QoL (WHOQoL-Bref scale [14.2-0.05* total days of MV; p=0.43]). Conclusion: Need for MV and duration of MV decrease patient PFS after ICU discharge.
Effect of cold chain interruptions on the shelf-life of fluid pasteurised skim milk at the consumer stage
Authors: Sadhu Sumita Paul
Published: March 2018

Abstract This study aimed to verify the effect of time and temperature abuse on bacterial numbers in fluid pasteurized skim milk by simulating the real-life scenario, which usually occurs when cold chain is interrupted by consumers prior to consumption that affect the shelf-life of milk. Total three trials were carried out in this study. Thermal abuse was simulated with temperature fluctuations from 5 °C. In the first trial, the information about holding the milk samples for 8 hours at three different temperatures of 15 °C, 20 °C and 25 °C was obtained using a data logger to predict the effect of temperature abuse on the milk microbial quality. Further, in the second and third trial, the effect of temperature abuse on bacterial numbers was examined by holding milk at 5 °C and then shifts temperature to 25 °C for 8 h and 6 h. The pH was monitored during storage. The total bacterial count was examined by the Standard Plate Count (SPC). The mean air temperature had the greatest impact on milk temperature. It took 3.0 h, 3.9 h and 4.2 h to warm up when exposed to the temperatures of 15 °C, 20 °C and 25 °C, respectively. The holding time of 8 h at 25 °C showed that bacterial numbers (1 x 105 CFU mL-1) were higher after 14 days of storage, but control samples at 5 °C (< 1 x 104 CFU mL-1) were still within the acceptable level (5 x 104 CFU mL-1). A holding time of 6 h at 25 oC showed much higher bacterial numbers (1 x 109 CFU mL-1) compared to control samples (1 x 107 CFU mL-1) which were held at 5 °C for 11 days. The pH of the milk decreased with increasing bacterial growth during the extended storage time. The results show that temperature abuse has a significant effect on milk microbial stability and shelf life. It is important to maintain the milk temperature at 5 °C or less as the bacterial growth directly depend on increasing temperature and holding time, which pose the potential risk of microbial hazards leading to foodborne illness. Thus, consumers must understand the factors associated with the safe handling of milk to keep it safe to use before the expiry date.
Large-scale migration of a school shark, Galeorhinus galeus , in the Southwestern Atlantic
Authors: Jaureguizar Andrés J. , Argemi Federico , Trobbiani Gastón , Palma Elbio D. , Irigoyen Alejo J.
Published: March 2018

ABSTRACT Knowledge of the spatial and temporal distribution patterns of chondrichthyans is critical for their effective management. In this study we report and analyze a large-scale latitudinal migration (~ 1,425 km) of a female school shark in the Southwestern Atlantic shelf where it is currently classified as Critically Endangered. During the austral summer (February 15, 2015), ninety-four school sharks were captured (75 females and 19 males) and tagged with fin tags in Nuevo Gulf (~ 42°43’S, 64°53’W, Argentina). A female of 112 cm total length was recaptured in Uruguayan shelf waters in the austral winter (August 17, 2015). This long displacement represents the first direct evidence to support Vooren and Lucifora’s hypothesis of a single transnational population of Galeorhinus galeus in the Southwestern Atlantic. The good agreement found between the school shark habitat conditions (salinity 33-34, temperature 12-17°C) and the warmer member of Subantarctic Shelf Waters suggests that the seasonal variation in school shark abundance within this region could be related to water masses movements.
SERUM ELECTROLYTES AND OUTCOME IN PATIENTS UNDERGOING ENDOSCOPIC GASTROSTOMY
Authors: VIEIRA Joana , NUNES Gonçalo , SANTOS Carla Adriana , FONSECA Jorge
Published: March 2018

ABSTRACT BACKGROUND: Percutaneous endoscopic gastrostomy (PEG) is a gold standard for long term enteral feeding. Neurologic dysphagia and head/neck cancer are the most common indications for PEG as they can lead to protein-energy malnutrition and serum electrolyte abnormalities, with potential negative impact on metabolic balance. Refeeding syndrome may also be related with severe electrolyte changes in PEG-fed patients and contribute to poor prognosis. OBJECTIVE: This study aims to evaluate the changes in serum concentrations of the main electrolytes and its possible association with the outcome. METHODS: Retrospective study of patients followed in our Artificial Nutrition Clinic, submitted to PEG from 2010 to 2016, having head/neck cancer or neurologic dysphagia, who died under PEG feeding. Serum electrolytes (sodium, potassium, chlorine, magnesium, calcium and phosphorus) were evaluated immediately before the gastrostomy procedure. Survival after PEG until death was recorded in months. RESULTS: We evaluated 101 patients, 59 with electrolyte alterations at the moment of the gastrostomy. Sodium was altered in 32 (31.7%), magnesium in 21 (20.8%), chlorine in 21 (20.8%), potassium in 14 (13.8%), calcium in 11 (10.9 %) and phosphorus in 11 (10.9%). The survival of patients with low sodium (<135 mmol/L) was significantly lower when compared to patients with normal/high values, 2.76 months vs 7.80 months, respectively (P=0.007). CONCLUSION: Changes in serum electrolytes of patients undergoing PEG were very common. More than half showed at least one abnormality, at the time of the procedure. The most frequent was hyponatremia, which was associated with significantly shorter survival, probably reflecting severe systemic metabolic distress.
LIVER TRANSPLANTATION IN HEPATITIS DELTA: SOUTH AMERICA EXPERIENCE
Authors: LIMA Daniel Souza , MURAD JÚNIOR Abdon José , BARREIRA Márcio Alencar , FERNANDES Guilherme Cardoso , COELHO Gustavo Rego , GARCIA José Huygens Parente
Published: March 2018

ABSTRACT BACKGROUND: The Amazon region is one of the main endemic areas of hepatitis delta in the world and the only one related to the presence of genotype 3 of the delta virus. OBJECTIVE: To analyze the profile, mortality and survival of cirrhotic patients submitted to liver transplantation for chronic hepatitis delta virus and compare with those transplanted by hepatitis B virus monoinfection. METHODS: Retrospective, observational and descriptive study. From May 2002 to December 2011, 629 liver transplants were performed at the Walter Cantídio University Hospital, of which 29 patients were transplanted due to cirrhosis caused by chronic delta virus infection and 40 by hepatitis B chronic monoinfection. The variables analyzed were: age, sex, MELD score, Child-Pugh score, upper gastrointestinal bleeding and hepatocellular carcinoma occurrence before the transplantation, perioperative platelet count, mortality and survival. RESULTS: The Delta Group was younger and all came from the Brazilian Amazon Region. Group B presented a higher proportion of male patients (92.5%) compared to Group D (58.6%). The occurrence of upper gastrointestinal bleeding before transplantation, MELD score, and Child-Pugh score did not show statistical differences between groups. The occurrence of hepatocellular carcinoma and mortality were higher in the hepatitis B Group. The survival in 4 years was 95% in the Delta Group and 75% in the B Group, with a statistically significant difference (P=0.034). Patients with hepatitis delta presented more evident thrombocytopenia in the pre-transplantation and in the immediate postoperative period. CONCLUSION: The hepatitis by delta virus patients who underwent liver transplantation were predominantly male, coming from the Brazilian Amazon region and with similar liver function to the hepatitis B virus patients. They had a lower incidence of hepatocellular carcinoma, more marked perioperative thrombocytopenia levels and frequent episodes of upper gastrointestinal bleeding. Patients with hepatitis by delta virus had lower mortality and higher survival than patients with hepatitis B virus.
SWALLOWING IN PATIENTS WITH LARYNGITIS
Authors: MODA Isabela , RICZ Hilton Marcos Alves , AGUIAR-RICZ Lilian Neto , DANTAS Roberto Oliveira
Published: March 2018

ABSTRACT BACKGROUND: Dysphagia is described as a complaint in 32% of patients with laryngitis. OBJECTIVE: The objective of this investigation was to evaluate oral and pharyngeal transit of patients with laryngitis, with the hypothesis that alteration in oral-pharyngeal bolus transit may be involved with dysphagia. METHODS: Videofluoroscopic evaluation of the swallowing of liquid, paste and solid boluses was performed in 21 patients with laryngitis, 10 of them with dysphagia, and 21 normal volunteers of the same age and sex. Two swallows of 5 mL liquid bolus, two swallows of 5 mL paste bolus and two swallows of a solid bolus were evaluated in a random sequence. The liquid bolus was 100% liquid barium sulfate and the paste bolus was prepared with 50 mL of liquid barium and 4 g of food thickener (starch and maltodextrin). The solid bolus was a soft 2.2 g cookie coated with liquid barium. Durations of oral preparation, oral transit, pharyngeal transit, pharyngeal clearance, upper esophageal sphincter opening, hyoid movement and oral-pharyngeal transit were measured. All patients performed 24-hour distal esophageal pH evaluation previous to videofluoroscopy. RESULTS: The evaluation of 24-hour distal esophageal pH showed abnormal gastroesophageal acid reflux in 10 patients. Patients showed longer oral preparation for paste bolus and a faster oral transit time for solid bolus than normal volunteers. Patients with laryngitis and dysphagia had longer preparation for paste and solid boluses, and a faster oral transit time with liquid, paste and solid boluses. CONCLUSION: A longer oral preparation for paste and solid boluses and a faster transit through the mouth are associated with dysphagia in patients with laryngitis.
COMPARISON OF THE LEVELS OF C-REACTIVE PROTEIN, GLP-1 AND GLP-2 AMONG INDIVIDUALS WITH DIABETES, MORBID OBESITY AND HEALTHY CONTROLS: AN EXPLORATORY STUDY
Authors: CAZZO Everton , PAREJA José Carlos , CHAIM Elinton Adami , COY Cláudio Saddy Rodrigues , MAGRO Daniéla Oliveira
Published: March 2018

ABSTRACT BACKGROUND: The glucagon-like peptides 1 and 2 (GLP-1/GLP-2) are gut hormones that may directly affect the glucose homeostasis and their activity seems to be significantly affected by chronic inflammation. OBJECTIVE: To evaluate the postprandial levels of glucagon-like peptides 1 and 2 (GLP-1/GLP-2), C-reactive protein (CRP), and the postprandial glucose and insulin levels among individuals with obesity, type 2 diabetes, and healthy controls. METHODS: An exploratory cross-sectional study, which involved individuals awaiting for bariatric/metabolic surgery and healthy controls. Postprandial levels of GLP-1, GLP-2, glucose, and insulin were obtained after a standard meal tolerance test. Inflammation was assessed by means of CRP. RESULTS: There were 30 individuals enrolled in the study, divided into three groups: non-diabetic with morbid obesity (NDO; n=11 individuals), diabetic with mild obesity (T2D; n=12 individuals), and healthy controls (C; n=7 individuals). The mean CRP levels were significantly higher in the NDO group (6.6±4.7 mg/dL) than in the T2D (3.3±2.2 mg/dL) and C groups (2.5±3.2 mg/dL) (P=0.038). The GLP-1 levels following standard meal tolerance test and the area under the curve of GLP-1 did not differ among the three groups. The GLP-2 levels were significantly lower in the NDO and T2D than in the C group following standard meal tolerance test at all the times evaluated. The area under the curve of the GLP-2 was significantly lower in the NDO and T2D groups than in the C group (P=0.05 and P=0.01, respectively). CONCLUSION: GLP-2 levels were impaired in the individuals with obesity and diabetes. This mechanism seems to be enrolled in preventing the worsening of the glucose homeostasis in these individuals.
REVIEW OF CELIAC DISEASE PRESENTATION IN A PEDIATRIC TERTIARY CENTRE
Authors: OLIVEIRA Gracinda Nogueira , MOHAN Rajiv , FAGBEMI Andrew
Published: March 2018

ABSTRACT BACKGROUND: Celiac disease is an immune-mediated disorder with a multiform presentation and therefore a challenging diagnosis. OBJECTIVE: Our purpose is to identify the epidemiological, clinical, laboratory and histologic characteristics of children with celiac disease at diagnosis and on follow-up. METHODS: Children with previously established or newly diagnosed celiac disease, admitted in a tertiary centre in a two-year period (2014-2016) were recruited. Data was collected retrospectively from electronic medical records and clinical notes, and subsequently analysed with SPSS version 20.0. RESULTS: A total of 159 patients, out of 312, were included. Age ranged from 1 to 17 years (mean ± SD: 8.5±4.5 years, 69% girls). Disease presentation was classical in 60%, non-classical in 25%, subclinical in 10% and 5% classified as potential celiac disease. Non-classical and subclinical profiles had a higher mean age at presentation but not statistically significant (P-value 0.24). The most frequent gastrointestinal features at presentation were abdominal pain (58%), diarrhea (43%) and bloating (27%). A positive family history for celiac disease was present in 24% (n=35). We found anaemia in 23%, low ferritin in 63% and a moderate to severe deficiency of 25-hydroxyvitamin D in 62%. celiac disease -specific serologic testing and esophagogastroduodenoscopy were performed in 99%. Histology revealed modified Marsh 2 or 3 enteropathy in 94%, the remaining had normal histology but positive human leukocyte antigen typing. Clinical improvement at 12 months of gluten-free diet was complete in 51% and partial in 49%. IgA tTG normalized after 12-30 months of gluten-free diet in 45%. On growth assessment at diagnosis and after 12-28 months of gluten-free diet, 100% had height increase (mean ±SD: 7.11±4.43 cm) and 96% weight gain (mean ±SD: 5.60±4.91 kg). CONCLUSION: Our findings outline the diverse clinical presentations of pediatric celiac disease that should be considered irrespective of age. Increased clinician’s awareness will enable an early diagnosis and treatment, with subsequent symptom and nutritional status improvement.
ASSOCIATION OF INTERLEUKIN-10 -1082 A/G (RS1800896) POLYMORPHISM WITH SUSCEPTIBILITY TO GASTRIC CANCER: META-ANALYSIS OF 6,101 CASES AND 8,557 CONTROLS
Authors: NAMAZI Abolfazl , FORAT-YAZDI Mohammad , JAFARI Mohammadali , FARAHNAK Soudabeh , NASIRI Rezvan , FOROUGHI Elnaz , ABOLBAGHAEI Seyed Mojtaba , NEAMATZADEH Hossein
Published: March 2018

ABSTRACT BACKGROUND: The promoter -1082 A/G (rs1800896) polymorphism of Interleukin-10 (IL-10) gene have been widely reported and considered to have a significant role on gastric cancer risk, but the results are inconsistent. OBJECTIVE: To clarify the association, we conducted a meta-analysis to investigate the associations IL-10 -1082 A/G polymorphism with gastric cancer. METHODS: Eligible articles were identified by searching databases including PubMed, Web of Science, and Google Scholar up to August 03, 2017. Odds ratios (OR) with corresponding 95% confidence intervals (CIs) were used to assess the association. RESULTS: A total of 30 case-control studies with 6,101 cases and 8,557 controls were included in this meta-analysis. Overall, a significant association between IL-10 -1082 A/G polymorphism and gastric cancer risk was observed under the allele model (G vs A: OR=1.305, 95% CI=1.076-1.584; P=0.007), heterozygote model and (GA vs AA: OR=1.252, 95% CI=1.252-1.054; P=0.011) and dominant model (GG+GA vs AA: OR=1.264, 95% CI=1.053-1.516; P=0.012). In the subgroup analysis by ethnicity, increased gastric cancer risk were found in Asians under the allele model (G vs A: OR=1.520, 95% CI=1.172-1.973; P=0.002), homozygote model (GG+GA vs AA: OR=1.571, 95% CI=1.023-2.414; P= 0.039), heterozygote model (GA vs AA: OR=1.465, 95% CI=1.192-1.801; P≤0.001) and dominant model (GG+GA vs AA: OR=1.448, 95% CI=1.152-1.821; P=0.002), but not among Caucasian and Latinos populations. CONCLUSION: These results suggested that the IL-10 -1082 A/G (rs1800896) polymorphism might contribute to the gastric cancer susceptibility, especially among Asians.
Hypertension management: what is the role of case management?
Authors: Ozpancar Nurhan , Pakyuz Sezgi Cinar , Topcu Birol
Published: March 2018

ABSTRACT Objective The aim of this study was to determine the effect of case management on hypertension management and on adherence to antihypertensive medication and chronic disease care of patients with hypertension. Method This study was conducted as an experimental and randomized controlled study. The sample of the study consisted of randomly selected patients with hypertension who did not have communication problems, who used antihypertensive medication treatment and whose treatment had been continuing for at least six months. The study group was given individual training (Hypertension causes, the risk factors, significance, unwanted side effects, medication treatment, changes in life style) and was applied case management model in hypertension – joint care protocol but no intervention was offered to the control group. Data was collected using the adherence to antihypertensive medication scale, the patient assessment of chronic illness care in the first and six months later interview. Results There was no significant difference between the study and control group according to adherence to antihypertensive medication and patient assessment of chronic illness care in the first interview. Otherwise, there were significant differences between the study and control group according to blood pressure, adherence to antihypertensive medication and patient assessment of chronic illness care in the six months later interview. The adherence to antihypertensive medication total score and the patient assessment of chronic illness care total score were significantly higher in the study group compared with control group in the six months later interview. Conclusion The case management plays an important role the in control of hypertension, and can improve adherence to antihypertensive medication and chronic illness care.
Comparison between the working environment of nurse managers and nursing assistants in the hospital context
Authors: Santos José Luís Guedes dos , Erdmann Alacoque Lorenzini , Peiter Caroline Cechinel , Alves Murilo Pedroso , Lima Suzinara Beatriz Soares de , Backes Vânia Marli Schubert
Published: March 2018

ABSTRACT Objective Comparing the working environment of nurse managers and nursing assistants in the hospital context. Method A mixed methods research with concomitant triangulation of data developed in a university hospital in the South of Brazil. Participants in the quantitative study were 94 nursing assistants and 12 nurse managers. The data were collected using the Brazilian Nursing Work Index − Revised (B-NWI-R) and analyzed through descriptive and inferential statistics. Eight (8) nurse managers and 18 nursing assistants were interviewed for the qualitative study. The data were analyzed through thematic analysis. Results The total B-NWI-R mean score for nurse managers was 2.15±0.39, and for nursing assistants it was 2.22±0.39. No statistical significance was identified in the comparison between the groups (p=0.508). The qualitative results show the existence of collaborative relationships between nurse managers and nursing assistants. Conclusion The working environment was similarly evaluated by nurse managers and nursing assistants in the hospital context.
Nursing interventions with people with obesity in Primary Health Care: an integrative review
Authors: Braga Vanessa Augusta Souza , Jesus Maria Cristina Pinto de , Conz Claudete Aparecida , Tavares Renata Evangelista , Silva Marcelo Henrique da , Merighi Miriam Aparecida Barbosa
Published: March 2018

ABSTRACT Objective Identify the knowledge produced on nursing interventions with people suffering from obesity in Primary Health Care. Method Integrative literature review of publications indexed in the databases: CINAHL, LILACS, MEDLINE, SciELO, SCOPUS and WEB OF SCIENCE, between 2011 and 2016. Results Thirty-three articles were selected. The knowledge produced covered two themes: “Counseling aimed at weight control and promotion of healthy lifestyle habits” and “Perception of Primary Health Care nurses regarding interventions with people with obesity.” Conclusion The results may help prompt reflections on professional training, management, and health services in terms of the relevance of nurses working with people suffering from obesity, with the support of digital technologies, motivational techniques, and nursing consultations. This could enhance their activities in the multiprofessional teams in which they participate at this healthcare level.
An ontology-based data integration framework for construction information management
Authors: Akinyemi Abiodun , Sun Ming , Gray Alasdair J G
Published: March 2018

Information management during the construction phase of a built asset involves multiple stakeholders using multiple software applications to generate and store data. This is problematic as data come in different forms and are labour intensive to piece together. Existing solutions to this problem are predominantly in proprietary applications, which are sometimes cost prohibitive for small engineering firms, or conceptual studies with use cases that cannot be easily adapted. In view of these limitations, this research presents an ontology-based data integration framework that makes use of open-source tools that support Semantic Web technologies. The proposed framework enables rapid answering of queries over construction data integrated from heterogeneous sources, data quality checks and reuse of project software resources. The attributes and functionalities of the proposed solution align with the requirements common to small firms with limited information technology skill and budget. Consequently, this solution can be of great benefit for their data projects.
Briefing: Time-bar provisions of the NEC3 Engineering and Construction Contract clause W1.3
Authors: Davis Terrence
Published: March 2018

This briefing examines the scope of clause W1.3(2) of the NEC3 Engineering and Construction Contract, which bars the contractor from referring disputes concerning actions of the project manager to adjudication. The briefing highlights a tendency of adjudicators and judges to expand the ambit of a dispute about project managers’ actions to include a dispute about the product of their actions, as is demonstrated in the case of WSP Cel Ltd v. Dalkia Utilities Services PLC.
ABD’NİN AFGANİSTAN VE IRAK’A MÜDAHALE SÜRECİNDE TÜRK-AMERİKAN İLİŞKİLERİ (THE NEW YORK TIMES ÇERÇEVELEMELERİ: 2001-2003)
Authors: Korkmaz Gökhan
Published: March 2018

11 Eylül terör saldırılarının ardından Afganistan’a yapılan müdahale sırasında dünya kamuoyunun desteğini almış olan ABD, 2003 yılında başlattığı Irak Savaşı’na meşruiyet kazandırmak amacıyla ortaya koyduğu Irak’taki kitle imha silahlarının mevcudiyeti iddiasını dünyaya kabul ettirememiş, gerçekten de savaşın bitiminde bu tür silahların varlığına rastlanamamıştır. ABD’nin NATO üyesi yakın bir müttefiki olmasının yanısıra Irak’ın komşusu olmasından kaynaklanan stratejik konumu nedeniyle, Türkiye de ister istemez kendisini bu savaşın paydaşlarından birisi olarak bulmuştur. Ancak gerek savaş öncesinde, gerekse savaş sırasında, Irak konusunda, ABD ile birçok kez görüş ayrılığı içerisine düşülmüş, bu da iki ülke arasındaki ilişkilerde zaman zaman gerginliğe yol açmıştır. Bu çalışma, iki ülke arasında Irak politikası nedeniyle yaşanan gerginliklerin Amerika’nın önde gelen gazetelerinden The New York Times’ta, 2001-2003 yıllları arasında, nasıl bir Türkiye görüntüsü sergilediğini ortaya çıkarmak amacıyla yapılmıştır.
Çin Dış Politikasında İttifak Yapmama Prensibi: Akademik Tartışmalar
Authors: Eliküçük Yıldırım Nilgün
Published: March 2018

Öz Bu çalışmada Çin uluslararası ilişkiler akademisindeki ittifak yapmama prensibiyle ilgili tartışmalar ele alınmıştır. Çalışmanın temel iddiası, Çin akademisinde dış politika tartışmalarının hükümetin çizdiği çerçeveden daha dinamik ve karmaşık olduğudur. Uluslararası ilişkiler akademisyenlerinin dış politika yapımındaki önemi sadece hükümetin politikalarını desteklemelerinden değil aynı zamanda alternatif politika üretebilmelerinden kaynaklanmaktadır. Bu yüzden akademik tartışmalar ittifak yapmama politikasında bir değişikliğe gidilip gidilmeyeceğini analiz etmek için önemli bir fikri temel sağlamaktadır. Çinli akademisyenlerin ittifak yapmama prensibiyle ilgili görüşleri üç başlıkta ele alınmıştır. İlk grup, ittifak yapmamanın yararlarını savunan ortodoksidir. İkinci grup, ittifak yapmaya yönelik bir strateji değişikliğini savunan revizyonistlerdir. Üçüncü grup ise, prensibin tamamen terk edilmeyip yeni duruma uygun bir takım tamamlayıcı tedbirler alınması gerektiğini düşünen ılımlılardır. Bu gruplar içinde revizyonistlerinfikirleri Çin’in ittifak politikasındaki olası bir değişikliğin hangi yönde olacağı konusunda önemli ipuçları vermektedir. İttifak yanlılarına göre potansiyel müttefik Rusya’dır. Revizyonistlerin fikirleri aynı zamanda Çin’de yükselen popüler milliyetçiliğinde bir yansımadır. Bu yüzden Çin’in ülke içinde yükselen milliyetçilik karşısında ittifak arayışı içine girmesi kaçınılmaz görünmektedir.
Kişi Örgüt Uyumunun Örgütsel Adalet Algısı ve Örgütsel Bağlılık İlişkisinde Aracılık Rolü
Authors: Köksal Kemal
Published: March 2018

Bu çalışmada örgütsel bağlılığın yaratılmasında etkili olan

değişkenlerden örgütsel adalet algısının ve kişi örgüt uyumunun rolü

incelenmiştir. Araştırma bir kamu kurumunda çalışan 213 kişiden kolayda

örnekleme yöntemiyle toplanan verilerin analizi ile gerçekleştirilmiştir.

Ölçekleri doğrulamak için doğrulayıcı faktör analizi, hipotezlerin testi için

ise korelasyon ve regresyon analizi yapılmıştır. Analiz sonucunda, örgütsel

adalet algısının ve kişi örgüt uyumunun örgütsel bağlılığı anlamlı bir şekilde

yordadığı ve örgütsel adalet algısı ve örgütsel bağlılık arasındaki ilişkide

kişi örgüt uyumunun tam aracılık etkisinin olduğu tespit edilmiştir.
Küresel Güvenliğin Dönüşümü; NATO Bağlamında Kavramsal, Tarihsel ve Teorik Bir Analiz
Authors: Şahin Güngör
Published: March 2018

Kuzey

Atlantik Antlaşması Örgütü (NATO) realist kurama uygun bir şekilde,

gerektiğinde güç kullanmak suretiyle Batı Bloğunun güvenliğini sağlamak

amacıyla kurulmuştur. Ancak Soğuk Savaş sonrası dönemde, Doğu Bloğu tehdidinin

ortadan kalkmasına ve nükleer silahların sınırlandırılması konusundaki

girişimlerin olumlu sonuçlanmasına rağmen, NATO’nun mevcudiyetini yitirmediği

gözlemlenmiştir. Örgüt, neo-liberal kuram doğrultusunda, üye devletlerin

güvenlik iş birliğini kolaylaştırdığı ve insani müdahalede bulunma kapasitesine

sahip olduğu gerekçesiyle varlığını sürdürmeye, 1990 sonrası dönemde sorumluluk

sahasını da genişleterek “alan dışı” görev ve yetkilerle hegemonyasını

arttırmaya devam etmiştir. Ayrıca 11 Eylül 2001 terör saldırılarından sonra,

neo-liberal kuram yanında sosyal inşacı kuramın; teröre destek veren ülkelere

karşı “biz” hissi yaratarak işbirliğini kolaylaştırdığı tezi, varlığının temel

dayanaklarından biri olmuştur. Çalışma, küresel güvenlik sistemi içindeki

değişimin unsurlarını tespit etmek, eski ve yeni dönem arasındaki bağlantıyı

kurabilmek ve değişen/dönüşen güvenlik anlayışında; realist, neo-liberal ve

sosyal inşacı kuramlar ışığında, Soğuk Savaş sonrası dönemdeki zirveleri ve

müdahaleleri çerçevesinde NATO’nun dönüşümünü değerlendirmektedir.
In-Gel Western Detection Using Near-Infrared Fluorescence v1
Authors: Biosciences LI-COR
Published: March 2018

Western blot detection of proteins requires separation of protein mixtures by electrophoresis, followed by transfer of the separated proteins to nitrocellulose or PVDF membranes for detection.The Odyssey Systems allow you to detect target proteins while still embedded in the gel, without transfer to a membrane using near-infrared secondary antibodies, such as LI-COR IRDye conjugates. Developed for: Aerius, and Odyssey Family of Imagers Please refer to your manual to confirm that this protocol is appropriate for the applications compatible with your Odyssey Imager model.
How to setup and perform a PCR experiment using GoTaq® G2 Master Mixes v1
Authors: Corporation Promega
Published: March 2018

GoTaq® G2 Green Master Mix(a,b)is a premixed ready-to-use solution containing GoTaq® G2 DNA Polymerase, dNTPs, MgCl2 and reaction buffers at optimal concentrations for efficient amplification of a wide range of DNA templates by PCR. GoTaq® G2 Green Master Mix contains two dyes (blue and yellow) that allow monitoring of progress during electrophoresis. Reactions assembled with GoTaq® G2 Green Master Mix have sufficient density for direct loading onto agarose gels. GoTaq® G2 DNA Polymerase exhibits 5 →3 exonuclease activity. GoTaq® G2 Green Master Mix is recommended for any amplification reaction that will be visualized by agarose gel electrophoresis and ethidium bromide staining. The master mix is not recommended if any downstream applications use absorbance or fluorescence excitation, as the yellow and blue dyes in the reaction buffer may interfere with these applications. The dyes absorb wavelengths in the range of 225–300nm, making standard A260 readings to determine DNA concentration unreliable. The dyes have excitation peaks at 488nm and in the range of 600–700nm that correspond to the excitation wavelengths commonly used in fluorescence detection instrumentation. For some instrumentation, such as a fluorescent gel scanner that uses a 488nm excitation wavelength, there will be minimal interference since it is the yellow dye that absorbs at this wavelength. Gels scanned by this method will have a light grey dye front (corresponding to the yellow dye front) below the primers.
Chloroplast transformation of the liverwort Marchantia polymorpha v1
Authors: Honkanen Suvi
Published: March 2018

This protocol was adapted from Chiyoda et al., 2007 and Boehm et al., 2015
Chloroplast transformation of the liverwort Marchantia polymorpha v2
Authors: Honkanen Suvi
Published: March 2018

This protocol was adapted from Chiyoda et al., 2007 and Boehm et al., 2015
Preschoolers' causal reasoning v1
Authors: Van Schijndel Tessa , Huijpen Kim , Visser Ingmar , Raijmakers Maartje
Published: March 2018

1 Administration protocol 2-5 Scoring forms (versions 1A, 1B, 2A, 2B) For communication about the translation of (parts of) the documents, please contact the authors.
Shell Closure N = 82 nuclei interpretation by the Cranked Nilsson-Strutinsky Model : 136-138Ce
Authors: Kaım Samra , Aboudı A. , Belgharbı R. , Laala A.
Published: March 2018

A theoretical studying of nuclei in the shell
closure region (N =82), in particular cerium isotopes 136-138Ce, has
been made in the frame of macroscopic-microscopic, Cranked Nilsson Strutinsky
(CNS)model. Many nuclear properties have been calculated and discussed: the
single particle energy, the total energy, the liquid drop energy, the moments
of inertia, the deformation parameters, the nuclei shape,  and potential energy surfaces (PES) have been
presented. High spin rotational bands of these isotopes have been
studied and interpreted based on fixed configurations in the frame of CNS code.
A good agreement is found with the observed results for these nuclei in the
recent works.
Simulation by Geant4 of hadrontherapy beam line
Authors: CHEMINGUI Fatima Zohra , BENRACHI Fatima
Published: March 2018

Hadrontherapy represents a pioneer technique, and only few centers
worldwide can provide this advanced and specialized cancer treatment. Geant4
(GEometry ANd Tracking 4) is a C++, free and open toolkit that used to simulate
the interaction of particles in matter. It is employed in various fields from
high-energy physics, nuclear physics to medicine. By means of Monte Carlo
simulation tool Geant4, we have simulated the hadrontherapy beam line typical
of a proton-therapy line modeled in the category of the advanced examples with
all its elements: the diffusers, range shifters, collimators and detectors.
This Simulation has permited the calculation of dose and Linear Energy Transfer
(LET). In this context, this study reports the first results of our simulation
realized by means of Geant4 10.2 version and their comparizon with those
obteined by Cironne.
KARAKTERISTIK KERUSAKAN HUTAN RAWA GAMBUT TROPIS TERDEGRADASI DI KALIMANTAN TENGAH
Authors: Rachmanadi Dony , Faridah Eny , Sumardi Sumardi , Der Meer Peter van
Published: March 2018

Peat swamp forest concessions and managements in Central Kalimantan have caused forest degradation resulting in the occurrence of forest fragmentation. The efforts on ecosystem restoration should be made based on the characteristics of fragmented peat swamp forest. This study aimed to find out the characteristics of degraded peat swamp forest assessed from the indicators of tree species diversity, community structure, and species dominance as well as their relationships with environmental conditions in various situations of fragmentation. The diversity of tree species tends to decrease following disturbance gradient, where the lowest was found near the edge. The community structure of the forest edge was dominated by small stand (diameter class of 6-10 cm) and dominated by Combretocarpus rotundatus of 60%. This condition was affected by environmental factors (67,2% - 71,8%): competition, site condition, microclimate and inundation.Keywords: disturbance characteristics; peat swamp forests; diversity; environmental factorsPengusahaan dan pengelolaan hutan rawa gambut selama ini di Kalimantan Tengah ternyata menyebabkan kerusakan yang menyebabkan hutan rawa gambut terfragmentasi. Usaha perbaikan ekosistem tersebut harus berdasarkan pada karakteristik dari ekosistem hutan rawa gambut yang terfragmentasi tersebut. Tujuan dari penelitian ini adalah untuk mempelajari karakteristik hutan rawa gambut terdegradasi yang terdiri dari indikator keanekaragaman jenis pohon, struktur komunitas, dan dominansi jenis serta hubungannya dengan kondisi lingkungan yang dilihat pada berbagai kondisi fragmentasi. Keanekaragaman jenis pohon semakin jauh dari hutan semakin rendah begitu juga dengan jumlah jenis dan kerapatan vegetasinya. Struktur komunitas pada bagian tepi hutan didominasi oleh tegakan berukuran kecil (kelas diameter 6-10cm) dan dominansi jenisnya hanya terpusat pada sedikit jenis dimana jenis Combretocarpus rotundatus mencapai 60%. Kondisi tersebut dipengaruhi oleh faktor lingkungan (67,2% - 71,8%) yaitu kompetisi dan kondisi lahan serta iklim mikro dan tinggi muka air tanah (genangan).Kata Kunci : karakteristik kerusakan; hutan rawa gambut; keanekaragaman; faktor lingkungan