bluuebunny/crossref_metadata_2025 huggingface dataset:
Visuo-motor interference is modulated by task interactivity: A kinematic study
Authors: Rocca Matilde , Sacheli Lucia Maria , Romeo Luca , Cavallo Andrea
Published: May 2023

Extensive evidence shows that action observation can influence action execution, a phenomenon often referred to as visuo-motor interference. Little is known about whether this effect can be modulated by the type of interaction agents are involved in, as different studies show conflicting results. In the present study, we aimed at shedding light on this question by recording and analyzing the kinematic unfolding of reach-to-grasp movements performed in interactive and noninteractive settings. Using a machine learning approach, we investigated whether the extent of visuo-motor interference would be enhanced or reduced in two different joint action settings compared with a noninteractive one. Our results reveal that the detrimental effect of visuo-motor interference is reduced when the action performed by the partner is relevant to achieve a common goal, regardless of whether this goal requires to produce a concrete sensory outcome in the environment (joint outcome condition) or only a joint movement configuration (joint movement condition). These findings support the idea that during joint actions we form dyadic motor plans, in which both our own and our partner’s actions are represented in predictive terms and in light of the common goal to be achieved. The formation of a dyadic motor plan might allow agents to shift from the automatic simulation of an observed action to the active prediction of the consequences of a partner’s action. Overall, our results demonstrate the unavoidable impact of others’ action on our motor behavior in social contexts, and how strongly this effect can be modulated by task interactivity.
ORGANIC FARMING-A WAY TOWARDS ECO SYSTEM: A STUDY WITH REFERENCE TO KHAMBHA TALUKA જૈવિક ખેતી પર્યાવરણ જાળવણી તરફનું પ્રયાણ: ખાંભા તાલુકાના સંદર્ભમાં અભ્યાસો
Authors: kaklotar Rekha A.
Published: May 2023

ખેતી ક્ષેત્ર ભારતીય અર્થતંત્રની કરોડરજ્જુ છે. આજે પણ લગભગ 60% જેટલા લોકો ખેતી ક્ષેત્ર સાથે સંકળાયેલા છે. આવા સંજોગોમાં સાતત્યપૂર્ણ અને ટકાઉ ખેત વિકાસ અનિવાર્ય છે. સજીવ ખેતીનું મૂળ ખેતી ક્ષેત્રના ઇતિહાસ સાથે જોડાયેલું છે. જૈવિક ખાદ્ય એ તાજેતરમાં ઝડપથી વિકાસ પામતું ક્ષેત્ર છે. તેનો વાર્ષિક વિકાસ દર ૨૦ ટકા જેટલો જોવા મળ્યો છે. રાસાયણિક ખાતરો અને રાસાયણિક જંતુનાશકો 20મી સદીની શરૂઆતમાં અમેરિકામાં અસ્તિત્વમાં આવ્યા ત્યારે ખેડૂતો તેને અપનાવવા માટે તૈયાર ન હતા. ડીડીટી તથા અન્ય રાસાયણિકો બજારમાં આવ્યા ત્યારે વૈજ્ઞાનિકો, ખેડૂતો તથા કૃષિ નિષ્ણાતો તેના ભવિષ્યના સંભવિત નુકસાન માટે તથા લાંબા ગાળાની અસરો અંગે પ્રશ્નો ઉદ્ભવતા હતા. સજીવ ખેતીમાં ખેડૂતોએ ઉત્પાદન ક્ષેત્રે વધુ પડકારોનો સામનો કરવો કે જેથી ગ્રાહકોની જરૂરિયાત સંતોષી શકે તથા સજીવ ખેતીની જરૂરિયાત પણ સંતોષી શકે.આ સંશોધન અભ્યાસ જૈવિક ખેતીનું પર્યાવરણ જાળવણીમાં શું મહત્વ છે તેના સંદર્ભમાં વિગતો રજૂ કરે છે. આ સંશોધન અભ્યાસ સૌરાષ્ટ્ર વિસ્તારના ખાંભા તાલુકાના સંદર્ભમાં હાથ ધરાયો છે. જેમાં ૫૦ ખેડૂતોના ઇન્ટરવ્યૂ દ્વારા તેમની પાસેથી ખેતપદ્ધતિ, સજીવ ખેતીના લાભ ગેરલાભ, ભવિષ્યમાં કઈ પદ્ધતિ અપનાવવા માંગે છે વગેરે વિશેની માહિતી પ્રાપ્ત કરવામાં આવી છે.
COVID-19 Exposure in Urban and Rural Areas
Authors: Wong Megan , Cai Delbert , Cai Raymond
Published: May 2023

The COVID-19 pandemic has majorly impacted the lives of people living in different living environments, such as large cities or small towns. However, there is limited knowledge about the difference in infection prevalence between urban and rural populations. To examine these differences, this study examined SARS-CoV-2 antibody levels in blood serum from 36 unvaccinated subjects of urban and rural backgrounds with no self-reported history of COVID-19 infection. Enzyme Linked Immunosorbent Assays (ELISA) detected the presence of SARS-CoV-2 antibodies in the subjects’ blood. IgG and IgM assays were used to distinguish between prior (recovered) and more recent infections, respectively. A t-test was conducted to identify a statistically significant difference, or lack thereof, between the antibody levels detected in urban and rural participants. The results indicated that there was no significant difference between the two experimental groups for both IgG and IgM (p = 0.09, 0.93, respectively), although the p-value for IgG was low enough to be notable. Overall, this study suggests that there is no major difference between urban and rural environments that impact susceptibility to SARS-CoV-2 infection, although more research with a greater sample size should be conducted.
Hallazgos ultrasonográficos y laparoscópicos en pacientes con endometriosis profunda
Authors: González Hugo , Saavedra Ivys
Published: May 2023

Objetivo: Determinar los hallazgos ultrasonográficos y laparoscópicos en pacientes con endometriosis profunda en el Servicio de Ginecología del Complejo Hospitalario Dr. Arnulfo Arias Madrid, Caja de Seguro Social (CHMDAAM - CSS). Metodología: Estudio descriptivo observacional transversal retrospectivo donde se evaluaron mediante expedientes clínicos los hallazgos ultrasonográficos y laparoscópicos en 48 pacientes con endometriosis en el servicio de Ginecología del Complejo Hospitalario Dr. Arnulfo Arias Madrid. Resultados: La prevalencia de endometriosis fue mayor en el grupo etario de 31 a 40 años (58%). La mayoría de la sintomatología presentada fue en el grupo de 31 a 40 años. Siendo la dismenorrea el síntoma más frecuente.
En los hallazgos ultrasonográficos, la mayoría se encontró en el comportamiento posterior, involucrando mayormente al recto. Los hallazgos laparoscópicos más frecuentes fueron en el comportamiento posterior. En nuestro estudio, 35 de 46 de las pacientes con hallazgos ultrasonográficos que demostraba endometriosis profunda, tenían en la laparoscopia endometriosis profunda. Es decir, el ultrasonido por mapeo de endometriosis fue capaz de predecir el 76% de los hallazgos por laparoscopia. Conclusiones: los hallazgos ultrasonográficos concuerdan en su mayoría con los hallazgos encontrados por laparoscopia, siendo el compartimiento posterior el más afectado, las lesiones en el recto fueron las más frecuentes encontradas.
Hidrops fetal no inmune
Authors: Linares Saskya , Solis-Delgado Alcibíades
Published: May 2023

El hidrops fetal no inmune es una complicación que ocurre durante el embarazo en la que se acumula líquido en los tejidos del feto, lo que puede provocar insuficiencia cardíaca y otros problemas de salud graves. La incidencia es baja (1:5000 embarazos). Las causas pueden incluir infecciones virales, trastornos genéticos, alteraciones del sistema cardiovascular fetal. El diagnóstico se realiza mediante ecografía prenatal y si se sospecha hidrops no inmune se pueden realizar pruebas adicionales para determinar la causa subyacente, como análisis de sangre (pruebas serológicas para infecciones), pruebas genéticas y análisis de líquido amniótico. El pronóstico va a depender de la gravedad de la afección, la causa subyacente y la respuesta al tratamiento. Pese a que el hidrops fetal no inmune no suele ser una afección recurrente, es importante que las mujeres embarazadas se sometan a controles prenatales regulares y se comuniquen con su médico si tienen el antecedente. Esto ayudará a detectar cualquier problema fetal lo antes posible y planificar el tratamiento adecuado.
Histerectomía total laparoscópica
Authors: González Hugo
Published: May 2023

Objetivo del estudio: Demostrar la técnica de una histerectomía total laparoscópica así como explicar cómo resolver una dificultad debido a un sangrado.Diseño: Realizar paso a paso la cirugía a través de un video con narración

Introducción: La histerectomía es el procedimiento quirúrgico que más se realiza en ginecología, sólo en Los Estados Unidos se efectúan más de 500,00 histerectomías por año. Las causas más frecuentes como indicación de una histerectomía por patología benigna son la fibromatosis uterina y los sangrados uterinos anormales. La primera histerectomía laparoscópica fue descripta por Reich en 1989 y mucho se ha avanzado desde aquella primera descripción en cuanto una técnica mejorada, desarrollo de mejor instrumental, así como imagen de alta calidad. Menos dolor postoperatorio, rápida recuperación, menor tasa de infecciones y un impacto positivo en la calidad de vida de las pacientes son algunos de los beneficios de este procedimiento por mínima invasión.

Intervención: En este caso realizamos una histerectomía total + salpingectomía total bilateral vía laparoscópica en una paciente de 44 años con cuadro de dolor tipo cólico bajo vientre, menorragia y anemia secundaria. Iniciamos la cirugía con acceso a la cavidad abdominal a nivel umbilical con técnica abierta o de Hasson y luego colocamos tres trocares accesorios de 5 mm en triangulación francesa además utilizamos una lente de 10 mm y 30° de visión y una torre de alta definición. A continuación efectuamos una inspección de la cavidad abdominopélvica y liberación de adherencia de epiplón a fosa iliaca derecha. Previo al inicio de la histerectomía identificamos ambos uréteres además de verificar la integridad del fondo de saco de Douglas. Iniciamos la histerectomía del lado izquierdo de la pelvis con la coagulación, sección y disección del ligamento redondo, hoja anterior del ligamento ancho, plica vesicouterina, mesosalpinx, ligamento uteroovárico y paquete vascular uterino y para este fin utilizamos dispositivo de energía avanzado de coagulación y sellado de las estructuras. Seguido pasamos a realizar maniobras iguales del lado derecho de la pelvis donde se presenta sangrado de origen venoso a la altura de inserción de ligamento uterosacro derecho y donde realizamos maniobras de clampeo - aspiración - visión para luego efectuar coagulación y sellado del vaso sangrante y controlar la situación. El siguiente paso corte de vagina con energía monopolar en modalidad de corte puro. Se extrae la pieza y se cierra la cúpula vaginal mediante puntos en “X” con un hilo absorbible, sintético y fuerza tenis de 30 días, calibre 1. Se verifica hemostasia se da por concluido el procedimiento.

Conclusión: La histerectomía laparoscópica es un procedimiento seguro, reproducible y ofrece a las pacientes las ventajas de una cirugía por mínima invasión: menor dolor postoperatorio, rápida recuperación, menor tasa de infección del sitio operatorio además de calidad de vida después de la cirugía.
Hội chứng thực bào máu liên quan với bệnh ác tính ở trẻ em
Authors: Đặng Tâm
Published: May 2023

TÓM TẮT

Đặt vấn đề: Hội chứng thực bào máu (HLH) là tình trạng đe doạ tính mạng do hoạt hóa quá mức hệ thống miễn dịch. HLH có thể là tiên phát hoặc thứ phát. HLH thứ phát thường được khởi phát bởi nhiễm virus, bệnh ác tính hoặc bệnh dạng thấp. HLH thứ phát liên quan với bệnh ác tính là tình trạng thường gặp ở người lớn, nhưng rất hiếm gặp ở trẻ em. Cho đến nay mới chỉ có một số ít trường hợp HLH liên quan bệnh ác tính ở trẻ em được báo cáo.

Báo cáo trường hợp: Chúng tôi báo cáo một trường hợp trẻ nam 4 tuổi, được chẩn đoán và điều trị bạch cầu cấp dòng lympho B đã đạt lui bệnh hoàn toàn, đang hóa trị giai đoạn duy trì. Trẻ biểu hiện sốt cao liên tục mặc dù đã dùng kháng sinh, các xét nghiệm đủ tiêu chuẩn chẩn đoán HLH và có điểm H score ở mức cao nghi ngờ HLH. Trẻ được điều trị với Dexamethasone đơn thuần theo phác đồ 8 tuần, trẻ đáp ứng tốt. Hiện đang được điều trị hóa chất giai đoạn duy trì trở lại.

Kết luận: HLH trong bối cảnh bệnh lý ác tính ở trẻ em vẫn là một thách thức vì tỷ lệ tử vong cao. Quyết định điều trị nên được đưa ra tùy từng trường hợp cụ thể. Cần có các nghiên cứu quy mô để cải thiện nhận thức và tiên lượng bệnh.

ABSTRACT

MALIGNANCY-ASSOCIATEDHAEMOPHAGOCYTICLYMPHOHISTIOCYTOSIS IN CHILDREN

Background: Hemophagocytic lymphohistiocytosis (HLH) is a life - threatening condition caused by excessive immune system activation. HLH can be primary or secondary. Secondary HLH is often triggered by viral infection, malignancy or rheumatoid disease. Secondary HLH associated with malignancy is common in adults, but very rare in children. To date, only a few cases of malignancy - associated HLH in children have been reported.

Case report: We report a 4 - year - old boy, diagnosed and treated for B-cell acute lymphoblastic leukemia, who achieved complete remission, undergoing maintenance chemotherapy. The child presented with persistently high fever despite antibiotic therapy, laboratory tests met criteria for HLH and high H-score suggest HLH. The child was treated with Dexamethasone alone according to the 8-week regimen, the children responded well. He have been currently receiving chemotherapy in the maintenance phase.

Conclusion: HLH in malignant disease in pediatrics remains a challenge that has substantial mortality. Treatment decisions must be taken case - by - case. Larger studies are needed to improve disease awareness and prognosis.
Foreign Electoral Interference: Normative Implications in Light of International Law, Human Rights, and Democratic Theory
Authors: Reimann Nils
Published: May 2023

Foreign interference in elections may have attracted increased public attention since 2016, but it is a practice virtually as old as modern electoral democracy itself. This book offers the most comprehensive account of its normative implications yet. It discusses relevant standards of international law, human rights, and democratic theory, thereby casting a net wide enough to address the fundamental value of human dignity as well as the conditions of real political autonomy. Ultimately, the book identifies potential deficits of legality, accountability, and legitimacy ensuing from certain types of foreign electoral interference, and it provides ideas on what can and should be done in response.
AN INVESTIGATION INTO THE RELATIONSHIP BETWEEN REWARD MANAGEMENT STRATEGIES AND ORGANIZATIONAL PERFORMANCE IN ZIMBABWEAN LOCAL AUTHORITIES (LA): A CASE STUDY OF MUTARE TOWN COUNCIL
Authors: Sharon Chisango , Faitira Manuere , Zororo Muranda
Published: May 2023

The importance of aligning an organisation’s Reward Management system to the overall business strategy cannot be overemphasized. Tshukudu (2022) in his latest article acknowledges that, Reward system is a vital tool for driving business growth and boosting staff morale. The increasingly volatile business environment have seen most Company executives constantly demanding evidence that reward systems produce changes in performance. Therefore, this research paper sought to examine the relationship between reward systems and performance using Mutare City Council as a case understudy. The study focused on administrative and low-level employees. The sample size chosen was (20). Simple random sampling technique was used to draw participants from different departments. The research utilised the pragmatic approach where both the quantitative and qualitative research methods were used to obtain an in-depth understanding of the problem under study. The data was presented and analysed using tables and graphs as well as the thematic approach for qualitative findings. The study findings revealed that there is a positive relationship between Reward systems and performance in local authorities. It further revealed that a well -managed reward system is advantageous because it improves employee engagement, employee participation and overally improved performance. The paper recommends that Local Authorities must use Total Reward management systems which takes into account both monetary and non- monetary benefits when rewarding employees.
Needs of Parents of Children with Cancer for a Parent Supportive Meeting
Authors: Susilawati Dwi , Sitaresmi Mei Neni , Mulatsih Sri , Handayani Krisna , Indraswari Braghmandita Widya , Kaspers Gertjan , Mostert Saskia
Published: May 2023

BACKGROUND: Parent supportive meetings (PSM) may assist families in reducing the distress of having a child with cancer. Little is known about what parents regard as their needs for support.
AIM: The purposes of this study were to investigate the needs and preferences of parents of children with cancer for PSM and its determinants.
METHODS: We conducted a cross-sectional study using semi-structured questionnaires. Parents of childhood cancer patients who attended an Indonesian academic hospital were recruited between March and July 2019.
RESULTS: Parents of 200 patients participated in this study (response rate 95%). Parents are interested in group (90%) and individual (84%) support to help them deal with stress related to their child’s illness. The best time to attend the supportive meeting is during treatment (53%), the best format is a drop-in basis (83%), and the best schedule is monthly (58%). Attendance is very important to: explore services and available support in the community (70%), get advice about family or relationship issues (62%), and learn how other parents cope with stress and anxiety (59%). Significantly more mothers (93%) than fathers (84%) are interested in supportive meetings (p = 0.046). More frequent meetings are preferred by low-educated (48%) than high-educated parents (31%, p = 0.015) and by younger (55%) than older parents (35%, p = 0.005).
CONCLUSION: This study shows that parents of children with cancer at an Indonesian academic hospital are interested in monthly drop-in-based PSM during the whole treatment course to help them better cope with stress related to their child’s illness.
The Role of Non-Selective Beta-Blockers (NSBBs) in Liver Cirrhosis
Authors: Prabundari Anak Agung Yunda , Wibawa I Dewa Nyoman
Published: May 2023

Non-selective beta-blockers (NSBBs) are one of the recommended treatments for portal hypertension in liver cirrhosis (LC). NSBB plays the role of primary as well as secondary prophylactic upper gastrointestinal bleeding in LC. NSBB therapy has been shown to effectively reduce the risk of variceal bleeding, reduction of portal pressure, and treat other complications of portal hypertension. The safety of NSBB therapy in cirrhosis requires a good therapeutic guide and considers the side effects. The indication of NSBB administration is adjusted according to the cirrhosis stage and the specific pathophysiology that occurs in cirrhosis. Conventional NSBBs such as propranolol and nadolol which are antagonists of β1 and β2 adrenergic receptors would induce decreased cardiac output and splanchnic vasoconstriction. Carvedilol is an NSBB with the addition of α1-adrenergic activity in reducing portal pressure stronger than conventional NSBB, so carvedilol can cause greater systemic arterial pressure reduction when compared to conventional NSBB. The appropriate treatment strategies can be applied in the use of NSBB to prevent more severe complications and reduce morbidity and mortality.
Tocilizumab Initiation based on Indicator in Patients Infected by Coronavirus-19 to Prevent Intubation
Authors: Permana Septian Adi , Sugiarto Adhrie , Manggala Sidharta Kusuma , Thamrin Muhammad Husni , Purwoko Purwoko , Ganitafuri Handayu
Published: May 2023

BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic has created severe medical and economic consequences worldwide since 2019. Tocilizumab is one of the therapies considered capable of improving the condition of patients with COVID-19. However, there is not much information about the best time to give tocilizumab.
METHODS: This was an analytical study with a retrospective cohort design, using the data of 125 patients infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with signs of acute respiratory distress syndrome in Dr. Moewardi Hospital, Surakarta, from March to August 2020. We analyzed various available clinical data to see which factors into clinical improvement with tocilizumab therapy.
RESULTS: Most patients showed clinical improvement after administration of tocilizumab. During the follow-up period, 21 patients died despite tocilizumab therapy. Significant risk factors associated with the need for intubation were heart rate, neutrophil, lymphocyte, pH, PaCO2, and PO2. The most influential variable on the need for intubation without being associated with other risk factors was PaO2 (p = 0.003, Confidence Intervals 95%).
CONCLUSIONS: Tocilizumab has a role in treating patients infected by SARS-CoV-2, preventing the need for intubation when given to patients in good saturation condition with oxygen supplementation without positive pressure (PaO2 >65mmHg; SpO2 >93%).
Effect of Two Retention Modalities on Single Midline Implant Supporting Mandibular Overdenture
Authors: Shaaban Ahmed , Mahrous Ahmed Ibrahim , Shaaban Sara Maher , Denewar Mohamed
Published: May 2023

AIM: The purpose of this research was to examine the effect of locator attachment versus retention silicone lining material on the supporting structure and retention of a single midline implant supporting mandibular overdenture.
METHODS: Sixteen patients with completely edentulous mandibles were selected for this study and divided into two groups. In all patients, a single implant was placed at midline area after cone-beam radiography was performed. Group I was retained with locator attachment, while Group II was retained with silicone material. Follow-up was carried out at denture insertion, 6 months and 12 months following insertion. Peri-implant bone loss as well as posterior bone loss was evaluated using cone-beam computerized tomography and retention was evaluated using force meter device and wire hook attaches to the prosthesis.
RESULTS: There was a statistically significant difference in peri-implant bone loss between the two groups at the 2nd follow-up period and at the end of the study period (p ≤ 0.05). There was no statistically significant difference in posterior bone loss between the two studied groups (p ≤ 0.05) and regarding retention that there was no statistically significant difference between the two groups along the follow-up periods.
CONCLUSION: From the results obtained from this study, it could be concluded that locator attachment showed lower peri-implant bone loss than retention silicone liner in the overall follow-up period with a statistically significant difference. This was attributed to the decrease in the effect of the resiliency of retention silicone liner over time and the more permanent effect of locator attachment.
Urethral Pain Syndrome: Treatment with Oxygen and Hyaluronic Acid
Authors: Vadalà Maria , Veronesi Ester , Garoia Flavio
Published: May 2023

AIM: The aim of our clinical study has been to evaluate the efficacy of the association between high concentration oxygen and hyaluronic acid (HA) for the treatment of urethral pain syndrome (UPS).
MATERIALS AND METHODS: Twenty women (45–65 years old) with suspected UPS diagnosis appealing to our Second Opinion Medical Consultation Network signed an informed consent form and were treated with oxygen/HA therapy treatment, 7 times a week, for a total of 5 weeks at the outpatient clinic (Clinic Ester Veronesi, Modena, Italy).The physicians of the Second Opinion Network followed up weekly from remote (WhatsApp, Skype) each treated patient as to state the effectiveness, tolerability, and side effects of the treatment.
RESULTS: We observed significant reductions in number of urgency urinary incontinence (−25.37 vs. −12.01 mean value), nocturia episodes (−24.01 vs. −11.23 mean value), volume voided in each micturition (−127.79 vs. −98.20 mean value), and micturitions per 24 h (−44.01 vs. −20.12 mean value). Analyses of the pre- and post-treatment scores showed a statistically significant improvement in Vaginal assessment scale, pain urgency frequency, and patient perception of bladder condition scale scores (p < 0.0305, p < 0.0001, and p < 0.0001, respectively). No side effects associated with the treatment were reported by the patients.
CONCLUSIONS: We can highlight that Caressflow® is effective and very well tolerated in UPS syndrome: The oxygen flow mixed with HA gives immediately a sense of freshness and urethro-bladder relaxation that lasts several hours. Further studies including larger sample sizes, placebo, and or challenge with other local and systemic treatments and different administration schedules versus longer follow-up are recommended.
Brand Image of Islamic Characters Perceived by Private Higher Education Institution Students in Indonesia
Authors: Noviani Wulan , Suprabowo Imam , Purnamasari Vita , Chong Mei Chan
Published: May 2023

BACKGROUND: Higher education institution (HEI) has created professional identity, and the characteristics of the profession have taught. HEI can also create a strong brand image in the minds of the public that convey the core values and distinguishe them from others. However, the perception of the brand image of Islamic characters remains limited to exploration among Bachelor nursing students, especially in private Islamic HEI in Indonesia. AIM: This study explores the brand image of Islamic characters perceived by nursing students in two private Islamic HEI in Indonesia. METHODOLOGY: A descriptive qualitative study was performed, 13 nursing students were recruited through purposive sampling. Within 30–45 min, the in-depth interview was conducted face-to-face through WhatsApp video calls. For data analysis, NVivo 12TM Plus and Colaizzi methods were used. RESULTS: The data analysis found two themes: (1) Finding the meaning of Islamic identity; and (2) providing Islamic-based care. There are six sub-themes identified: (1) Internalizing of Islamic university vision; (2) Holding Islamic sharia as a Muslim nurse; (3) Applying Islamic and professional values; (4) Starting with “bismillah” and closing with “alhamdulillah”; (5) Praying the patients as an obligation; and (6) Guiding “talqin” for facing death. CONCLUSION: Private HEI students perceive Islamic identity as influenced by institutional brand identity and professional identity in Indonesia.
One Step Tenotomy in Congenital Torticollis: A Case Report
Authors: Azharuddin Azharuddin , Sitohang Robby
Published: May 2023

BACKGROUND: Congenital muscular torticollis (CMT) is a common pediatric abnormality involving sternocleidomastoid (SCM) muscle. The pathogenesis of CMT has yet to be elucidated, but intrauterine abnormalities seem to be a plausible explanation. This condition, if left untreated, may result in craniofacial asymmetry, neck pain, and limited neck movement. We reported a case of an 11-year-old girl with CMT, which symptoms were first noticed at the age of 4, but were neglected by her parents, the patient was then treated with a complete unipolar SCM release.
CASE PRESENTATION: An 11-year-old girl presented with neck stiffness and limited head movement, first noticed at the age of 4, but was neglected. These symptoms worsened within the last few weeks. Physical examination revealed tension and tightness in the left SCM muscle. The patient then underwent complete unipolar release of SCM muscle and proceeded to aggressive physiotherapy for 3 months and put to rigid collar neck for the next 3 weeks. Follow-up was done in the fourth week and a full range of motion (ROM) of the neck was achieved.
DISCUSSION: The timing of surgery could yield a good result if performed within 1–4 years of age. However, another literature stated that surgical intervention in the older patient with CMT could still result in better outcomes. Therefore, in this case, we proceeded to perform a complete unipolar release on the left SCM muscle. Post-operative results were satisfying, with significant improvement in neck ROM.
CONCLUSION: Surgical approach in adolescents with CMT may still carry a favorable outcome, in terms of better ROM and neck motion. Subsequent physiotherapy and brace placement were crucial to maintaining the results of the surgery.
The Correlation between High Sensitive C-reactive Protein Levels and Gensini Score in Diabetes Patients
Authors: Rotty Linda , Wantania Frans , Wowor Ribka
Published: May 2023

BACKGROUND: Coronary artery disease is a disease caused by atherosclerotic plaques in the coronary arteries. The severity of coronary artery disease can be assessed objectively by coronary angiography. Many prospective studies have shown that inflammatory biomarkers with high sensitivity C-reactive protein (hsCRP) are independent predictors of cardiovascular events.
AIM: The aim of this study was to determine the correlation of hsCRP and Gensini score in subjects with coronary artery disease and diabetic patients.
METHODS: This study used an analytical observational design with a cross-sectional study to see the correlation between hsCRP and Gensini score in coronary artery disease subjects. The total sample was 40 subjects with a diagnosis of coronary artery disease and diabetes. Examination of angiography and hsCRP levels was performed on all subjects.
RESULTS: A total of 40 diabetic patients were included in the analysis. The mean age in this study was 57.98 ± 8.71 years old. The mean Gensini score in this study was 63.90 ± 40.79 years old. The median hsCRP level in this study was 13.05 (0.3–245.6). There was a significant correlation between hsCRP levels and the Gensini score (r = 0.346, p = 0.029).
CONCLUSION: There was a significant positive relationship between hsCRP levels and Gensini score, where an increase in the hsCRP value was also followed by an increase in the Gensini score; therefore, the hsCRP value can be used to assess the degree of coronary artery disease lesions.
The Impact of Sputnik SARS-CoV-2 Vaccines on Antibody Response in the Egyptian Population
Authors: Ismail Ghada , Abdelhamid Dalia , Mostafa Marwa Salah , Fahim Noha Alaa Eldin , Elshafei Ahmed , Abdelghaffar Hossam , Naguib Nashwa , Taher Omnia , Asker Menna
Published: May 2023

BACKGROUND: The coronavirus disease 2019 (COVID-2019) causes the severe contagious acute respiratory syndrome. Therefore, massive vaccination campaign is mandatory to control the spread. Sputnik COVID-19 vaccines induce immunity through different mechanisms involving antibody response that bind to the spike protein to neutralize the viral entry into the cells.
AIM: This study aims to compare the titers of specific antibodies in the pre- and post-vaccination sera in the vaccinated Egyptian population to evaluate the efficacy of the sputnik vaccine.
METHODS: Samples were collected from 205 adult volunteers receiving the Sputnik vaccine in the Reference Laboratory of Egyptian University Hospitals. Samples were collected before vaccination and within 1, 2, or 3 months after receiving two doses of Sputnik SARS-CoV-2 vaccines from August to October 2021, serum samples collected were tested by quantitative chemiluminescent immunoassay using (Mindray CL-960i chemiluminescence analyzer, India) at the Reference laboratory of Egyptian University Hospitals for neutralizing antibodies, anti-spike antibodies, and total antibody levels before and after vaccination.
RESULTS: The results of the 205 paired samples illustrated that there was a statistically significant difference between pre- and post-vaccination antibody levels with a p-value of (< 0.001) indicating that the vaccine produced significantly high levels of antibodies.
CONCLUSION: COVID-19 Sputnik vaccines induce immunity through an antibody response that binds to the virus to neutralize its entry into cells. Our study showed a significant increase in the measured post-vaccination levels of the three antibodies among the enrolled volunteers compared to the basal pre-vaccination level and thus sputnik vaccine protects against SARS-CoV-2 infections.
An Unusually Long Appendix: A Case Report and Literature Review
Authors: Todorovic Slobodan , Toskovic Borislav , Gačić Jasna , Karaca Hana , Colakovic Natasa
Published: May 2023

BACKGROUND: Acute appendicitis is one of the most common conditions in emergency surgery and appendectomy is the most frequently performed surgical procedure. The complexity of this pathology is reflected in the numerous congenital malformations and anatomical variations of the vermiform appendix. Anatomical variations are mainly related to its length and position. The average length of the appendix was found to be 9.5 cm in the male and 8.7 cm in the female, but different length has been reported, from 1 cm to even a 33 cm on the cadaver.
CASE PRESENTATION: A 34-year-old man was admitted to the general surgery department due to symptoms that began the previous day. The patient complained of lumbar pain which later migrated to the periumbilical region and the right lower quadrant (RLQ) of the abdomen followed by fever, nausea, and vomiting. On clinical examination, he had a tenderness in RLQ with abdominal guarding. Laboratory analyzes showed leukocytosis and high markers of inflammation. Urinalysis and abdominal ultrasound were normal. Taking into consideration the clinical presentation and laboratory parameters, a decision was made to proceed for an open appendectomy. Intraoperatively, the appendix was inflamed, very long, partly retrocaecal, and partly paracolic in position, with two coils, extending upward. After dividing the mesoappendix, it measured 20 cm in length. The appendectomy was performed. Post-operative recovery was without complications. The patient was discharged from the hospital on the 3rd post-operative day.
CONCLUSION: Although acute appendicitis is very frequent condition in emergency surgery, making the diagnosis could be challenging due to numerous differential diagnostic dilemmas. The position of the appendix and direction of its extension could lead to misdiagnosis. The synthesis of clinical examination, laboratory analyzes, and diagnostic procedures should lead clinicians to the right diagnosis and surgical treatment, avoiding possible complications and additional costs.
Three Years Recurrence Free of Hemorrhoid Artery Ligation-Rectoanal Repair with No Doppler Guided on Grade III of Internal Hemorrhoid Disease
Authors: Bagus Budhi Ida
Published: May 2023

BACKGROUND: Surgical treatment of internal hemorrhoid is still challenging, short- and long-term clinical outcome were the most common issue. Chronic pain and recurrence case are the most common problem. Since it has been announced, HAL-RAR with Doppler guided is the treatment of choice, although it has economic issue on using this standard technique especially in the developing country which has limitation on health insurance.
AIM: Using the same procedure as the standard HAL-RAR procedure and direct vision ligation, we hope that it could evaluate the clinical response of these modification technique on symptomatic Grade III of internal hemorrhoid cases.
METHODS: We will evaluate the long-term clinical outcome of modified no Doppler guided technique on grade III of internal hemorrhoid cases. The inclusion criteria are the grade III of internal hemorrhoid, not associated with rectal cancer. A history of previous procedure or recurrence disease will be excluded from the study. Post-operative pain, 3 years recurrence disease, will be evaluated.
RESULTS: We reported 65 patients, both of them have pain and bleeding. The procedure can be performed safely using direct vision and rectoscope. After 3 years, we reported there was no recurrence disease, no post-operative bleeding, and tolerable post-operative pain. We reported one case of chronic pain due to proctitis and could be managed conservatively.
CONCLUSION: No Doppler-guided HAL-RAR was effective in controlling the post-operative pain, acceptable long-term clinical outcome with no recurrence.
Effectiveness of Marine Bioactive Compound Fucoidan in Stimulating Osteoblast Cells Formation: A Systematic Review
Authors: Hamrun Nurlindah , Purnamasari Daranisa Wulan , Yusuf Andi Sitti Hajrah , Ruslin Muhammad
Published: May 2023

BACKGROUND: Bone loss in the oral cavity can occur in various situations, including periodontitis-related issues and complications after tooth extraction. A damaged or lost alveolar bone can be restored through a tissue engineering approach. Fucoidan, a marine biopolymer derived from brown algae, is one biomaterial that aids bone regeneration since it contains biomaterials that can generate new osteoblast cells.
AIM: The purpose of this review is to determine whether fucoidan can be employed to promote osteoblast cell growth during bone repair.
METHODS: The search strategy was performed in PubMed; Elsevier (Scopus); ScienceDirect; Libgen, and Google Scholar. In addition, a manual hand searching was performed to locate and identify additional studies.
RESULTS: Based on the reviewed articles, it has been discovered that five met the inclusion criteria and found that the marine bioactive compound fucoidan can significantly increase the expression of ALP activity.
CONCLUSION: Fucoidan is considered to have biological properties, including antithrombotic, anticoagulant, and antioxidant. It also serves as a phenotypic marker during the early stages of osteoblastic differentiation.
Unique Clinical Manifestation of Infective Endocarditis in Children: A Case Series
Authors: Rahayuningsih Sri Endah , Kuswiyanto Rahmat Budi , Apandi Putria , Setiabudi Djatnika , Manurung Berton Juniper , Hasna Monika
Published: May 2023

BACKGROUND: Infective endocarditis (IE) was a significant cause of morbidity and mortality, particularly in children with congenital heart disease (CHD). Infective endocarditis could occur in all ages with higher in children below 1-year-old, including neonates. Various clinical manifestations of IE in children make it difficult to make a prompt diagnosis and appropriate management. Finding in echocardiography could help clinicians determine the diagnosis of IE. Systemic embolization could cause many complications that may present as chief complaint underlying patient hospitalization.
CASE PRESENTATION: We present case series of diverse manifestation of IE in children in Bandung, West Java, Indonesia. Two cases had a history of structural heart disease, while one case with no history of any structural heart disease before.
CONCLUSION: Wide range of symptoms that could occur in children with IE, made it challenging to make a proper diagnosis.
Antifungal Activity Test of Ethanol Extracts and Ethyl Acetate and N-Hexane Fraction of Sea Grapes (Caulerpa Racemosa) on the Growth of the Fungi Trichophyton mentagrophytes
Authors: Hainil Sri , Mayefis Delladari , Ghiffari Habibie Deswilyaz , Erda Roza , Leondri Tessa , Firanika Anjeli
Published: May 2023

BACKGROUND: Sea grape (Caulerpa racemosa) is one of the marine plants that produce active compounds that can be used as medicinal ingredients with antifungal properties to inhibit fungal growth.
AIM: The purpose of this study was to determine whether the ethanolic extract of the ethyl acetate fraction and n-Hexane of sea grapes taken from Kampung Terih, Riau Islands could inhibit the growth of the fungus Trichophyton mentagrophytes.
METHODS: The antifungal activity was tested using the paper disk diffusion method with variant concentrations of ethanol extract, namely, 25%, 50%, 75%, and 100%, ethyl acetate and n-hexane fractions were 20,000 ppm, 30,000 ppm, 40,000 ppm, and 50,000 ppm.
RESULTS: The results showed that the ethanolic extract of sea grapes could inhibit the growth of T. mentagrophytes fungus with the formation of an average diameter at each concentration of 0 mm; 3.4 mm; 5.4 mm; and 8.4 mm. The ethyl acetate fraction of Sea grapes formed an average diameter at each concentration of 9.7 mm; 11.51 mm; 13.5 mm; 15.8 mm.
CONCLUSION: Based on the results of the study, it was concluded that the ethanol extract and the ethyl acetate fraction of sea grapes could inhibit the fungus T. mentagrophytes with moderate inhibition, while the n-hexane fraction of sea grapes could not inhibit the fungus T. mentagrophytes.
Factors Affecting Treatment Outcome of Metastatic Breast Cancer: Single Institution Study
Authors: shamsaldin Sara , Abdelmalek Reem Mamdouh , Ibrahim Noha Yehia , Mohamed Ahmed Abdelhafeez
Published: May 2023

BACKGROUND: Metastatic breast cancer (MBC) is an incurable disease.
AIM: The goal of therapy is to prolong survival and amelioration of quality of life. However, the benefit of later systemic treatment lines is not clear.
METHODS: This was a retrospective study of 345 MBC patient., assessment of progression free survival (PFS) survival with first line of treatment and second, third, fourth, fifth, and sixth lines of therapy, and analysis of different prognostic factors.
RESULTS: The median overall survival (OS) was 31.7 month. The median PFS was 8.1 versus 3 month for first line of treatment and beyond. Where median PFS1, PFS 2, PFS 3, PFS 4, PFS 5, and PFS 6 were 8.1, 5.8, 3.8, 4.8, 3.4, and 2.6, respectively. PFS of first line was significantly prolonged in hormone positive luminal subtype, bone only metastasis, age above 35, ECOG I-II, and oligometastatic (p = 0.041, 0.038, 0.023, 0.034, 0.0001, and 0.001, respectively). Post-progression survival was 23.4 months and it was significantly prolonged in hormone positive luminal subtype, bone only metastasis, age above 35, ECOG I-II and PFS more than 6 months with first line.
CONCLUSION: PFS is reduced with using more treatment lines in MBC. Patients with luminal subtype, bone only metastasis, age above 35, ECOG I-II, and PFS more than 6 months with first line may have the best benefit from later lines.
Pathomechanism of Liver Fibrosis and Mesenchymal Stem Cells in its Resolution Process
Authors: Husein Anggun Lestary , Liem Isabella Kurnia
Published: May 2023

Liver fibrosis is a disease process that, without adequate treatment, can lead to liver failure and can be life-threatening. This disease is reversible and appropriate therapy can prevent further liver damage. Liver transplant therapy is the only treatment for an end-stage liver disease that works, but it has various obstacles and limitations in its implementation. Therefore, nowadays, mesenchymal stem cells (MSCs) have become a hope of therapy for liver fibrosis. Our literature review describes the pathomechanism of liver fibrosis and the steps of its resolution, accompanied by the possible role of MSCs in supporting the process. The activation of several complex pathways regulates liver fibrosis, and its resolution, involving Transforming Growth Factor (TGF)-β, signal transducer and activator of transcription-3, and Wnt/β-catenin signaling is involved in Hepatic Stellate Cells (HSCs) activation, which are precursors of myofibroblasts (MFs) and causes fibrosis. The presence of the High-mobility group box-1 pathway, which also induces the production of proinflammatory cytokines and the role of matrix metalloproteinases (MMPs)/tissue Inhibitors of MMPs s and Syndecan-1, is incorporated into the extracellular matrix (ECM). In repairing liver damage, four steps of liver fibrosis resolution are required, such as preventing further damage, restoring the intrahepatic balance of inflammation, removing and inactivating MFs, and ECM degradation associated with arresting the eight pathways of the fibrosis mechanism. MSCs can help resolve liver fibrosis and speed up wound healing, increase hepatocyte survival, and suppress HSCs activation by blocking fibrosis mechanism pathways such as TGF-β and pro-inflammatory factors such as tumor necrosis factor-alpha, interferon-gamma, IL-6, IL-17, and IL-23, in addition to an elevated level of an anti-inflammatory factor like IL-10.
Functional Outcome of Total Hip Arthroplasty in Patient with Flexion Contracture due to Hip Ankylosis: A Rare Case Report
Authors: Dusak I Wayan Suryanto , Wiguna I Gusti Ngurah Indra , Febyan Febyan , Ciatawi Kartini
Published: May 2023

BACKGROUND: Performing total hip arthroplasty (THA) or total hip replacement (THR) in hip ankylosis is not a simple procedure.
CASE PRESENTATION: We presented a complicated case of a patient with flexion contracture and ankylosis of hip joint due to neglected avascular necrosis of femoral head treated with THR on one thigh, and periprosthetic fracture on the other which was also treated with THR later. One year after the surgery, the both hips function was improved and the patient was able to walk without assistive device.
CONCLUSION: Total hip replacement is a modality that could be considered for the treatment of advanced AVNFH and ankylosis of hip joint, with femoral periprosthetic fracture as one of its potential complications.
The Nutritional Lipid Profiles of Marine Fish from Medan, Indonesia
Authors: Silalahi Yosy , Masfria Masfria , Sinaga Siti Morin , Siburian Rikson
Published: May 2023

BACKGROUND: Evaluation of the nutritional value of fish is very important because fish contains essential fatty acids. Fatty acids substances in fish are very important for brain growth and the immune system of the fetus and baby, are also useful as cardioprotective, antihypertensive, anti-thrombolytic, cognitive development, fat metabolism, and anti-inflammatory.
AIM: The aim of this research is to determine the nutritional index of marine fish based on the fatty acid composition that is circulated in Medan City.
METHODS: Fish samples were collected from traditional markets; those is Thunnus spp., Lutjanus argentimaculatus, Sardina pilchardus, Rastrelliger kanagurta, and Euthynnus affinis. While, fish oil was produced from extracted with n-hexane and characterization by determining the acid, saponification, iodine, and peroxide value, respectively. The analysis of fatty acid composition was carried out by gas chromatography method.
RESULTS: The result of research shows, the proportion of fatty acids in marine fish samples was saturated fatty acid (SFA) >monounsaturated fatty acid >polyunsaturated fatty acid. From the nutritional index based on fatty acid composition, the best nutritional fish is Thunnus spp. based on the index value of atherogenic index (IA) and hypocholesterolemic/hypercholesterolemic.
CONCLUSION: As for the ratio of omega-6/omega-3, polyunsaturated/SFA (P/S), and thrombogenic index (IT), that is in the second rank category, so it can conclude that Thunnus sp. has the best nutritional index among the five types of marine fish.
OM Assessing the Justification in Seeking Compensation for Sports Injury
Authors: Lalić Hrvoje
Published: May 2023

BACKGROUND: This paper shows the role of occupational medicine in assessing the justification for seeking compensation for a sports injury.
CASE PRESENTATION: A 23-year-old female candidate applied for admission to the Police. Starting in 2022, the Academy tightened the admission criteria and started testing candidates by professional selection. The candidate was injured at the “Marine” training ground, breaking both lower leg bones. She is now seeking compensation from the Ministry of the Interior. Like for other jobs with special working condition, it is known that before hiring future police officers, they have to pass the preliminary occupational medicine examination. The same applies to enrolment in sports clubs, for practicing sports and before entering competitions. The candidate asks whether she should have had a medical examination before applying for training as a police officer, that is, before psychophysical testing. Only candidates who pass the tests can be admitted to the Police Academy at the Ministry of Internal Affairs, which are followed by a medical examination and the signing of an employment contract. The state cannot be expected to pay trainers for potential candidates and their training, for only about a quarter of candidates pass the selection.
CONCLUSION: The candidates themselves must be aware of their psychophysical capabilities, and it is to be expected that sportswomen, even amateurs, skilled and at least moderately fit, will apply for the above mentioned position of policewoman, bearing in mind the complexity of the future profession.