bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Thiosemicarbazone Derivatives and Fusarium culmorum (Wm.G. Sm.) Sacc. Infection of Winter Wheat Seedlings on Their Health Status and Soil Biological Activity
Authors: Jamiołkowska Agnieszka , Skwaryło-Bednarz Barbara , Mielniczuk Elżbieta , Bisceglie Franco , Pelosi Giorgio , Degola Francesca , Gałązka Anna , Grzęda Emilia
Published: January 2022

Climate change has an impact on agricultural production, including the greater persistence of plant pathogens in the environment. Therefore, the question arises as to how to effectively and safely protect plants by using chemicals, the number of which is decreasing each year. The aim of this study was to evaluate the fungistatic effect of 2 acetylthiophenethiosemicarbazone (2actpTS) and Cis-jasmonethiosemicarbazone (JTS) against Fusarium culmorum (Fc) on winter wheat seedlings. The influence of thiosemicarbazones (TSs) on the health status and phytotoxicity of seedlings and soil biological activity was investigated. Before TSs application (watering or spraying), soil was infected with F. culmorum (strain No. 37). The substance type and method of its application significantly influenced only the fresh weight of the seedlings. The varying phytotoxicity of the molecules depended primarily on their application method to the plants. The highest seedling phytotoxicity was recorded when compounds were applied during watering and the lowest when they were sprayed. The results showed that the application of substances 2actpTS and JTS, both in the form of watering and spraying, had a positive effect on plant health status, as expressed by the disease index (DI) value. The presence of the infectious agent and the type of chemical compound increased soil enzyme activity. The highest total number of bacteria was found in the soil that was infected with Fc and in soil samples where JTS was applied by watering and spraying. The highest utilization of amines, amides and amino acids by microorganisms was found in the samples where JTS was applied. The obtained results will be used to create intermediate products for the protection of cereals against Fusarium diseases, not only at the stage of germination and tillage of plants, but also at subsequent developmental stages.
Multidrug-Resistant Bacteria on Healthcare Workers’ Uniforms in Hospitals and Long-Term Care Facilities in Cyprus
Authors: Lena Pavlina , Karageorgos Spyridon A. , Loutsiou Panayiota , Poupazi Annita , Lamnisos Demetris , Papageorgis Panagiotis , Tsioutis Constantinos
Published: January 2022

Healthcare workers’ (HCW) clothing has been shown to harbor multidrug-resistant bacteria (MDRB) and may contribute to transmission. The aim of this study was to evaluate presence of MDRB on HCW uniforms in Cyprus. A cross-sectional study was carried out in 9 hospital wards and 7 long-term care facilities (LTCFs) in Nicosia, Cyprus, from April–August 2019. Sampling of HCW uniform pockets was conducted at the end of the first shift. Personal hygiene and other habits were recorded during personal interviews. Among 140 sampled HCW (69 from hospitals, 71 from LTCFs), 37 MDRB were identified, including 16 vancomycin-resistant enterococci (VRE), 15 methicillin-resistant Staphylococcus aureus (MRSA), 5 extended spectrum b-lactamase (ESBL)-producing bacteria, and 1 carbapenem-resistant Acinetobacter baumannii. Presence of MDRB was higher in LTCFs compared to hospitals (p = 0.03). Higher MDRB rates in uniforms were noted in HCWs that worked <1 year (41.7% vs. 21.1%) and in HCWs that opted for home laundering (23.5% vs. 12.5%) or visited the toilet during shifts (38.1% vs. 20.2%). Our findings indicate that HCW uniforms harbor MDRB and relevant interventions may reduce transmission risk. We identified LTCFs as an important area for targeted measures. Additional factors associated with HCW practices, characteristics, and attire laundering practices represent areas for improvement, particularly in LTCFs.
Co-Lateral Effect of Octenidine, Chlorhexidine and Colistin Selective Pressures on Four Enterobacterial Species: A Comparative Genomic Analysis
Authors: Lescat Mathilde , Magnan Mélanie , Kenmoe Sonia , Nordmann Patrice , Poirel Laurent
Published: January 2022

Bacterial adaptation to antiseptic selective pressure might be associated with decreased susceptibility to antibiotics. In Gram-negative bacteria, some correlations between reduced susceptibility to chlorhexidine (CHX) and polymyxins have been recently evidenced in Klebsiella pneumoniae. In the present study, four isolates belonging to distinct enterobacterial species, namely K. pneumoniae, Escherichia coli, Klebsiella oxytoca and Enterobacter cloacae, were submitted to in-vitro selective adaptation to two antiseptics, namely CHX and octenidine (OCT), and to the antibiotic colistin (COL). Using COL as selective agent, mutants showing high MICs for that molecule were recovered for E. cloacae, K. pneumoniae and K. oxytoca, exhibiting a moderate decreased susceptibility to CHX, whereas OCT susceptibility remained unchanged. Using CHX as selective agent, mutants with high MICs for that molecule were recovered for all four species, with a cross-resistance observed for COL, while OCT susceptibility remained unaffected. Finally, selection of mutants using OCT as selective molecule allowed recovery of K. pneumoniae, K. oxytoca and E. cloacae strains showing only slightly increased MICs for that molecule, without any cross-elevated MICs for the two other molecules tested. No E. coli mutant with reduced susceptibility to OCT could be obtained. It was therefore demonstrated that in-vitro mutants with decreased susceptibility to CHX and COL may be selected in E. coli, K. pneumoniae, K. oxytoca and E. cloacae, showing cross-decreased susceptibility to COL and CHX, but no significant impact on OCT efficacy. On the other hand, mutants were difficult to obtain with OCT, being obtained for K. pneumoniae and E. cloacae only, showing only very limited decreased susceptibility in those cases, and with no cross effect on other molecules. Whole genome sequencing enabled deciphering of the molecular basis of adaptation of these isolates under the respective selective pressures, with efflux pumps or lipopolysaccharide biosynthesis being the main mechanisms of adaptation.
Beta Lactams Plus Daptomycin Combination Therapy for Infective Endocarditis: An Italian National Survey (BADAS)
Authors: Corcione Silvia , Lupia Tommaso , Pallotto Carlo , Giacobbe Daniele Roberto , De Benedetto Ilaria , Stroffolini Giacomo , Mornese Pinna Simone , Tascini Carlo , Bassetti Matteo , De Rosa Francesco Giuseppe ,   on behalf of SITA GIOVANI (Young Investigators Group of the Società Italiana Terapia Antinfettiva)
Published: January 2022

Background: infective endocarditis (IE) remains a severe disease frequently encountered in clinical practice and often requiring interdisciplinary medical and surgical management. This national survey aims to describe the clinical prescribing habits of the use of daptomycin in the setting of IE and the possible role for combination therapy with beta-lactams. Methods: The study was a cross-sectional internet-based questionnaire survey on therapy with daptomycin. The questionnaire was designed with closed-ended questions and distributed using the SurveyMonkey® platform between October 2019 to December 2020. Results: 55 clinicians from twelve Italians regions joined the questionnaire. The survey reported use of daptomycin as first-line choice in 31.48% of cases and as the first-line anti-MRSA agent in 44.44%. The empiric use of daptomycin was stated in the high suspicion of MRSA rather than MSSA, enterococcal or streptococcal IE. The rationale of daptomycin for the empirical treatment of native and prosthetic valve IE was mostly the possibility of administering an aminoglycoside-sparing combination regimen, high bacterial killing rate and high clinical efficacy. Conclusions: In conclusion, in selected patients, daptomycin could be a feasible option for the treatment of infective endocarditis in line with data from the European registry of daptomycin.
Broad-Spectrum Antimicrobial, Antioxidant, and Anticancer Studies of Leaf Extract of Simarouba glauca DC In Vitro
Authors: Ramasamy Shanmuga Priya , Rajendran Anitha , Pallikondaperumal Muthukrishnan , Sundararajan Priya , Husain Fohad Mabood , Khan Altaf , Hakeem Mohammed Jamal , Alyousef Abdullah A. , Albalawi Thamer , Alam Pravej , Ali Hazim M. , Alqasim Abdulaziz
Published: January 2022

The current study aimed to screen the preliminary phytochemicals in the leaf extract of the medicinal plant Simarouba glauca and to analyze its potential antimicrobial, antioxidant and anticancer properties. The phytochemical profile of the methanol extract was analyzed, and bioactive compounds were identified using chromatography, FTIR and GCMS. Antimicrobial activity and Minimum Inhibitory Concentration (MIC) were determined against 14 bacterial and 6 fungal strains. Moreover, the synergistic effect of a plant extract with commercially available antibiotics was also evaluated using the checkerboard method. The ethanolic and methanolic extracts showed exclusive activity against S. aureus and profound activity against E. coli and S. marcescens. Upon comparing breakpoints, methanolic extract demonstrated higher antimicrobial activity with a MIC value of 3.2 mg/mL against the test pathogens. Furthermore, the extracts demonstrated potential antioxidant activity; methanol extract had higher antioxidant potential compared to the ethanol extract. The major proactive bioactive compound with maximum antioxidant capacity was observed to be terpenoids. The methanol extract of S. glauca showed significant cytotoxicity against the MCF-7 breast cancer cell line with an IC50 value of 16.12 µg/mL. The overall results of our work provide significant evidence for the usage of methanolic extract of S. glauca as an efficient ethnomedicinal agent and a potential candidate for relieving many human ailments.
Protection Scheme for a Wavelength-Division-Multiplexed Passive Optical Network Based on Reconfigurable Optical Amplifiers
Authors: Lee Hong-Sing , Yang Chun-Liang , Chou Chien-Hsiang
Published: January 2022

This paper demonstrates a wavelength-division-multiplexed passive optical network (WDM-PON) scheme based on novel reconfigurable optical amplifiers (ROAs). The measured switching characteristics of the ROA3 constructed with a 2 × 2 crossbar optical switch and a four-port reversible optical circulator (OC) and a conventional EDFA can meet the requirements of most network management and surveillance. The self-made four-port reversible OC’s response time is less than 2 ms, and its insertion losses are about 1 dB or less for all the transmission paths and switching states. An optimal design of ROAs is proposed and evaluated for bidirectional optical amplifier protection, in which ROA3 has an EDF length of 7.5 m long with a 1480 nm pump laser and possesses a backward or forward pumping configuration with the corresponding pump power of 200 mW or 50 mW. We verified the scheme’s feasibility through a simulation of WDM-PON systems with 40 downstream and upstream channels. This scheme enables the intelligent protection switching in practical operation scenarios for high-capacity multi-wavelength networks.
Long Term Effects of Reduced Track Tamping Works
Authors: Marschnig Stefan , Neuper Georg , Hansmann Fabian , Fellinger Michael , Neuhold Johannes
Published: January 2022

Tamping needs to guarantee safety in limiting geometric failures in isolated points, reduce dynamic forces by a smooth through-going longitudinal level, and provide a certain riding comfort for passengers. Although different methods are applied to describe geometry deterioration, the amount of tamping needed is seldomly addressed. In this work, we evaluated and compared different tamping regimes and their long-term consequences by extrapolating the longitudinal level of track. Forecasting beyond one tamping action needs a precise positioning of measurement data and a solid methodology. We found that tracks can be operated by repairing isolated defects for more than ten years without running into technical and operational trouble, and even reducing budgets in this period. However, the long-term perspective financially shows the contrary: continuous through-going maintenance keeps track quality at a high level and provides the basis for a long service life.
An Algorithm for Obtaining 3D Egg Models from Visual Images
Authors: Zlatev Zlatin , Georgieva-Nikolova Mariya , Lukanov Hristo
Published: January 2022

Mathematical models for describing the shape of eggs find application in various fields of practice. The article proposes a method and tools for a detailed study of the shape and peripheral contours of digital images of eggs that are suitable for grouping and sorting. A scheme has been adapted to determine the morphological characteristics of eggs, on the basis of which an algorithm has been created for obtaining their 3D models, based on data from color digital images. The deviation from the dimensions of the major and minor axes measured with a caliper and the proposed algorithm is 0.5–1.5 mm. A model of a correction factor has been established by which the three-dimensional shape of eggs can be determined with sufficient accuracy. The results obtained in this work improve the assumption that the use of algorithms to determine the shape of eggs strongly depends on those of the bird species studied. It is approved with data for Mallard eggs which have a more elliptical shape and correspondingly lower values of correction coefficient ‘c’ (c = 1.55–4.96). In sparrow (c = 9.55–11.19) and quail (c = 11.71–13.11) eggs, the form tends to be ovoid. After testing the obtained model for eggs from three bird species, sparrow, mallard, and quail, the coefficient of the determination of proposed model was R2 = 0.96. The standard error was SE = 0.08. All of the results show a p-value of the model less than α = 0.05. The proposed algorithm was applied to create 3D egg shapes that were not used in the previous calculations. The resulting error was up to 9%. This shows that in the test, the algorithm had an accuracy of 91%. An advantage of the algorithm proposed here is that the human operator does not need to select points in the image, as is the case with some of the algorithms developed by other authors. The proposed methods and tools for three-dimensional transformation of egg images would be applicable not only for the needs of poultry farming, but also in ornithological research when working with different shaped varieties of eggs. Experimental results show that the proposed algorithm has sufficient accuracy.
Automatic Clustering of Students by Level of Situational Interest Based on Their EEG Features
Authors: Othman Ernee Sazlinayati , Faye Ibrahima , Hussaan Aarij Mahmood
Published: January 2022

The usage of physiological measures in detecting student’s interest is often said to improve the weakness of psychological measures by decreasing the susceptibility of subjective bias. The existing methods, especially EEG-based, use classification, which needs a predefined class and complex computational to analyze. However, the predefined classes are mostly based on subjective measurement (e.g., questionnaires). This work proposed a new scheme to automatically cluster the students by the level of situational interest (SI) during learning-based lessons on their electroencephalography (EEG) features. The formed clusters are then used as ground truth for classification purposes. A simultaneous recording of EEG was performed on 30 students while attending a lecture in a real classroom. The frontal mean delta and alpha power as well as the frontal alpha asymmetry metric served as the input for k-means and Density-Based Spatial Clustering of Applications with Noise (DBSCAN) clustering algorithms. Using the collected data, 29 models were trained within nine domain classifiers, then the classifiers with the highest performance were selected. We validated all the models through 10-fold cross-validation. The high SI group was clustered to students having lower frontal mean delta and alpha power together with negative Frontal Alpha Asymmetry (FAA). It was found that k-means performed better by giving the maximum performance assessment parameters of 100% in clustering the students into three groups: high SI, medium SI and low SI. The findings show that the DBSCAN had reduced the performance to cluster dataset without the outlier. The findings of this study give a promising option to cluster the students by their SI level, as well as address the drawbacks of the existing methods, which use subjective measures.
LaFe1-xNix as a Robust Catalytic Oxygen Carrier for Chemical Looping Conversion of Toluene
Authors: Gu Haiming , Yang Juan , Song Guohui , Cui Xiaobo , Niu Miaomiao , Zhao Shanhui
Published: January 2022

Chemical looping biomass gasification is a novel technology converting biomass into syngas, and the selection of oxygen carrier is key for efficient tar conversion. The performance of LaFe1-xNix as a robust catalytic oxygen carrier was investigated in the chemical looping conversion of toluene (tar model compound) into syngas in a fixed bed. LaM (M = Fe, Ni, Mn, Co, and Cu) was initially compared to evaluate the effect of transition metal on toluene conversion. LaFe (partial oxidation) and LaNi (catalytic pyrolysis) exhibited better performance in promoting syngas production than other oxygen carriers. Therefore, Ni-substituted ferrite LaFe1-xNix (x = 0, 0.2, 0.4, 0.6, 0.8 and 1) was further developed. The effects of Ni-substitution, steam/carbon ratio (S/C), and temperature on toluene conversion into C1 and H2 were evaluated. Results showed that the synergistic effect of Fe and Ni promoted toluene conversion, improving H2 yield yet with serious carbon deposition. Steam addition promoted toluene steam reforming and carbon gasification. With S/C increasing from 0.8 to 2.0, the C1 and H2 yield increased from 73.9% to 97.5% and from 197.7% to 269.6%, respectively. The elevated temperature favored toluene conversion and C1 yield. LaFe0.6Ni0.4 exhibited strong reactivity stability during toluene conversion at S/C = 1.6 and 900 °C.
Atlas-Based Evaluation of Hemodynamic in Ascending Thoracic Aortic Aneurysms
Authors: Catalano Chiara , Agnese Valentina , Gentile Giovanni , Raffa Giuseppe M. , Pilato Michele , Pasta Salvatore
Published: January 2022

Atlas-based analyses of patients with cardiovascular diseases have recently been explored to understand the mechanistic link between shape and pathophysiology. The construction of probabilistic atlases is based on statistical shape modeling (SSM) to assess key anatomic features for a given patient population. Such an approach is relevant to study the complex nature of the ascending thoracic aortic aneurysm (ATAA) as characterized by different patterns of aortic shapes and valve phenotypes. This study was carried out to develop an SSM of the dilated aorta with both bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV), and then assess the computational hemodynamic of virtual models obtained by the deformation of the mean template for specific shape boundaries (i.e., ±1.5 standard deviation, σ). Simulations demonstrated remarkable changes in the velocity streamlines, blood pressure, and fluid shear stress with the principal shape modes such as the aortic size (Mode 1), vessel tortuosity (Mode 2), and aortic valve morphologies (Mode 3). The atlas-based disease assessment can represent a powerful tool to reveal important insights on ATAA-derived hemodynamic, especially for aneurysms which are considered to have borderline anatomies, and thus challenging decision-making. The utilization of SSMs for creating probabilistic patient cohorts can facilitate the understanding of the heterogenous nature of the dilated ascending aorta.
A New Calculation Method of Cutterhead Torque Considering Shield Rolling Angle
Authors: Shen Xiang , Yuan Dajun , Jin Dalong , Cao Chengyong
Published: January 2022

The existing cutterhead torque calculation method usually simplifies the characteristics of the shield, which ignores the rolling angle. In this paper, the cross-river shield project of Wuhan Metro Line 8 is taken as the research focus. Firstly, the measured data of the cutterhead torque (CT), the rolling angle and rotation direction were analyzed. Then on this basis, the penetrability, tunneling thrust, and rolling angle were taken as the influential factors to analyze CT sensitivity. Finally, based on the theoretical calculation model, a modified solution of CT was obtained considering the rolling angle. The results show that the rolling angle can be reduced to zero by changing the direction of the cutterhead rotation; the rolling angle has a greater impact on CT than the other two factors as shown through the analysis of the range difference and Statistical Product and Service Solutions (SPSS) method. As the absolute value of the rolling angle increases, CT also increases, and the relationship between them is linear. To a certain extent, the rolling angle of the shield can reflect the difficulty of tunneling and the running status. By monitoring the rolling angle of the shield, the prediction of CT can be more in line with the actual construction conditions.
Influence of the Weld Joint Position on the Mechanical Stress Concentration in the Construction of the Alternative Skid Car System’s Skid Chassis
Authors: Jilek Petr , Berg Jan , Tchuigwa Baurice Sylvain Sadjiep
Published: January 2022

This paper deals with the optimization of the crossbars, parts of the existing frame of the experimental system of the Alternative SkidCar. This part plays a crucial role and is designed to enable and ensure reduced adhesion conditions between the vehicle and the road. To this end, its optimization targeted here is performed using both analytical calculations and simulations in MSC Adams software, wherein the loading forces and boundary conditions on the frame support wheels are obtained considering the static conditions, as well as the change of the direction of travel. The least favourable load observed was used, later on, as the input value for the strength analysis of the frame. The analysis was performed using the finite element method (FEM) in SolidWorks. Based on the linear and nonlinear analyses performed, the course of stress on the frame arms and critical points with the highest stress concentration were determined. Subsequently, according to the results obtained, a new design for the current frame was proposed and, thereby, warrants greater rigidity, stability and strength to the entire structure, while reducing its weight and maximizing the potential of the selected material. The benefit of the current contribution lies in the optimization of the current frame shape, in terms of the position of weld joints, the location of the reinforcements and the thickness of the material used.
Effective and Low-Maintenance IMTA System as Effluent Treatment Unit for Promoting Sustainability in Coastal Aquaculture
Authors: Resende Luís , Flores Juan , Moreira Cláudia , Pacheco Diana , Baeta Alexandra , Garcia Ana Carla , Rocha Ana Cristina Silva
Published: January 2022

Integrated multitrophic aquaculture (IMTA) is a versatile technology emerging as an ecological and sustainable solution for traditional monoculture aquacultures in terms of effluent treatment. Nevertheless, IMTA is still poorly applied in aquaculture industry due to, among other reasons, the lack of effective, low-investment and low-maintenance solutions. In this study, one has developed a practical and low maintenance IMTA-pilot system, settled in a semi-intensive coastal aquaculture. The optimisation and performance of the system was validated using Ulva spp., a macroalgae that naturally grows in the fishponds of the local aquaculture. Several cultivation experiments were performed at lab-scale and in the IMTA-pilot system, in static mode. The specific growth rate (SGR), yield, nutrient removal, N and C enrichment, protein and pigment content were monitored. Ulva spp. successfully thrived in effluent from the fish species sea bream (Sparus aurata) and sea bass (Dicentrarchus labrax) production tanks and significantly reduced inorganic nutrient load in the effluent, particularly, NH4+, PO43− and NO3−. The enrichment of nitrogen in Ulva spp.’s tissues indicated nitrogen assimilation by the algae, though, the cultivated Ulva spp. showed lower amounts of protein and pigments in comparison to the wild type. This study indicates that the designed IMTA-pilot system is an efficient solution for fish effluent treatment and Ulva spp., a suitable effluent remediator.
The Effects of Six-Month Subalpine Training on the Physical Functions and Athletic Performance of Elite Chinese Cross-Country Skiers
Authors: Sun Zhihong , Zhang Yan , Xu Datao , Fei Yaqi , Qiu Qiner , Gu Yaodong
Published: January 2022

Purpose: This study investigated the changes in the blood indices, specific athletic abilities, and physical fitness of outstanding cross-country skiers, trained in the subalpine; Methods: Twenty-eight athletes (twenty males and eight females) from the National Cross-country Ski Training Team completed sub-alpine training during the 2020–2021 snow season. The athletes′ physical functions were evaluated by collecting blood from elbow veins and measuring blood biochemical indexes. To compare the treadmill roller-skiing athletic ability and physical fitness of athletes before and after subalpine; Results: Male and female athletes showed different trends in red blood cells (RBC), hemoglobin (Hb), cortisol (C), Creatine Kinase (CK) and blood urea (BU) (p < 0.05 or p < 0.01). Overall, the female athletes’ mean values of RBC, Hb, CK, and BU were lower than that of male athletes, while C was just the opposite. Comparing the athletic performance of athletes before and after the subalpine, it was found that blood lactate concentrations were significantly lower in both male and female athletes at the same load intensity (p < 0.05 or p < 0.01), whereas 10 km endurance running and 1 RM deep squat were significantly higher in both male and female athletes (p < 0.05 or p < 0.01). Conclusions: After 6 months of subalpine training, cross-country skiers improved their oxygen-carrying capacity and anabolism, and showed significant improvements in specific athletic ability, physical endurance, acid tolerance and 1 RM absolute strength for both male and female athletes.
Evolution in Approach to Colour in Tall Buildings’ Architecture on the Isle of Dogs, London, UK
Authors: Zimnicka Agnieszka , Balanicka Ewa , Kroll Aleksandra
Published: January 2022

Architects’ approach towards colour in architectural design evolved radically in the recent 50 years, and ranges from a modernist aversion to a vernacular appreciation. These changes were linked to the development of culture, technology and scientific knowledge in different areas connected to human functioning. The authors have examined evolution in design of tall buildings in the Isle of Dogs in London (UK) since the 1980s. The area experienced major growth spurs in the turn of the 20th and 21st centuries, resulting in the greatest concentration of tall buildings in London today. The Island has been a playground for architects who have developed a range of approaches to the design of towers. The authors observed the evolution of architectural style, analyzed application of colour and made connections between scale, beauty and human behaviour. They concluded that colour in tall buildings’ architecture on the Isle of Dogs is predominantly used to disguise their massing. Colour detail facilitates the domestic feel of a public realm. Therefore, alongside decorative quality, and if considerately applied, colour may positively influence the quality of living and working environments.
Simulation of the Multi-Timescale Stratospheric Intrusion Processes in a Typical Cut-Off Low over Northeast Asia
Authors: Chen Dan , Zhou Tianjiao , Guo Dong , Ge Shuhao
Published: January 2022

This study used the FLEXPART-WRF trajectory model to perform forward and backward simulations of a cut-off low (COL) event over northeast Asia. The analysis reveals the detailed trajectories and sources of air masses within the COL. Their trajectories illustrate the multi-timescale deep intrusion processes in the upper troposphere and lower stratosphere (UTLS) caused by the COL. The processes of air intrusion from the lower stratosphere to the middle troposphere can be divided into three stages: a slow descent stage, a rapid intrusion stage and a relatively slow intrusion stage. A source analysis of targeted air masses at 300 hPa and 500 hPa shows that the ozone-rich air in the COL primarily originated from an extratropical cyclone over central Siberia and from the extratropical jet stream. The sources of air masses in different parts of the COL show some differences. These results can help explain the ozone distribution characteristics in the main body of a COL at 300 hPa and at 500 hPa that were revealed in a previous study.
Assimilation of Ground-Based Microwave Radiometer on Heavy Rainfall Forecast in Beijing
Authors: Qi Yajie , Fan Shuiyong , Li Bai , Mao Jiajia , Lin Dawei
Published: January 2022

Ground-based microwave radiometers (MWRPS) can provide continuous atmospheric temperature and relative humidity profiles for a weather prediction model. We investigated the impact of assimilation of ground-based microwave radiometers based on the rapid-refresh multiscale analysis and prediction system-short term (RMAPS-ST). In this study, five MWRP-retrieved profiles were assimilated for the precipitation enhancement that occurred in Beijing on 21 May 2020. To evaluate the influence of their assimilation, two experiments with and without the MWRPS assimilation were set. Compared to the control experiment, which only assimilated conventional observations and radar data, the MWRPS experiment, which assimilated conventional observations, the ground-based microwave radiometer profiles and the radar data, had a positive impact on the forecasts of the RMAPS-ST. The results show that in comparison with the control test, the MWRPS experiment reproduced the heat island phenomenon in the observation better. The MWRPS assimilation reduced the bias and RMSE of two-meter temperature and two-meter specific humidity forecasting in the 0–12 h of the forecast range. Furthermore, assimilating the MWRPS improved both the distribution and the intensity of the hourly rainfall forecast, as compared with that of the control experiment, with observations that predicted the process of the precipitation enhancement in the urban area of Beijing.
A Multi-Year Study of GOES-13 Droplet Effective Radius Retrievals for Warm Clouds over South America and Southeast Pacific
Authors: Correia Alexandre L. , Mendonça Marina M. , Nobrega Thiago F. , Pugliesi Andre C. , Cecchini Micael A.
Published: January 2022

Geostationary satellites can retrieve the cloud droplet effective radius (re) but suffer biases from cloud inhomogeneities, internal retrieval nonlinearities, and 3-D scattering/shadowing from neighboring clouds, among others. A 1-D retrieval method was applied to Geostationary Operational Environmental Satellite 13 (GOES-13) imagery, over large areas in South America (5∘ N–30∘ S; 20∘–70∘ W), the Southeast Pacific (5∘ N–30∘ S; 70∘–120∘ W), and the Amazon (2∘ N–7∘ S; 54∘–73∘ W), for four months in each year from 2014–2017. Results were compared against in situ aircraft measurements and the Moderate Resolution Imaging Spectroradiometer cloud product for Terra and Aqua satellites. Monthly regression parameters approximately followed a seasonal pattern. With up to 108,009 of matchups, slope, intercept, and correlation for Terra (Aqua) ranged from about 0.71 to 1.17, −2.8 to 2.5 μm, and 0.61 to 0.91 (0.54 to 0.78, −1.5 to 1.8 μm, 0.63 to 0.89), respectively. We identified evidence for re overestimation (underestimation) correlated with shadowing (enhanced reflectance) in the forward (backscattering) hemisphere, and limitations to illumination and viewing configurations accessible by GOES-13, depending on the time of day and season. A proposition is hypothesized to ameliorate 3-D biases by studying relative illumination and cloud spatial inhomogeneity.
Excitations of the nS States of Atomic Hydrogen by Electron Impact, Excitation Rate Coefficients, and Phase Shifts: Comparison with Positron Impact Excitation
Authors: Bhatia Anand K.
Published: January 2022

The excitation cross-sections of the nS states of atomic hydrogen, n = 2 to 6, by electron impact on the ground state of atomic hydrogen were calculated using the variational polarized-orbital method at various incident electron energies in the range 10 to 122 eV. Converged excitation cross-sections were obtained using sixteen partial waves (L = 0 to 15). Excitation cross-sections to 2S state, calculated earlier, were calculated at higher energies than before. Results obtained using the hybrid theory (variational polarized orbital method) are compared to those obtained using other approaches such as the Born–Oppenheimer, close-coupling, R-matrix, and complex-exterior scaling methods using only the spherical symmetric wave functions. Phase shifts and elastic cross-sections are given at various energies and angular momenta. Excitation rate coefficients were calculated at various electron temperatures, which are required for plasma diagnostics in solar and astrophysics to infer plasma parameters. Excitation cross-sections are compared with those obtained by positron impact excitation.
An Improved Evaluation Methodology for Mining Association Rules
Authors: Bao Fuguang , Mao Linghao , Zhu Yiling , Xiao Cancan , Xu Chonghuan
Published: January 2022

At present, association rules have been widely used in prediction, personalized recommendation, risk analysis and other fields. However, it has been pointed out that the traditional framework to evaluate association rules, based on Support and Confidence as measures of importance and accuracy, has several drawbacks. Some papers presented several new evaluation methods; the most typical methods are Lift, Improvement, Validity, Conviction, Chi-square analysis, etc. Here, this paper first analyzes the advantages and disadvantages of common measurement indicators of association rules and then puts forward four new measure indicators (i.e., Bi-support, Bi-lift, Bi-improvement, and Bi-confidence) based on the analysis. At last, this paper proposes a novel Bi-directional interestingness measure framework to improve the traditional one. In conclusion, the bi-directional interestingness measure framework (Bi-support and Bi-confidence framework) is superior to the traditional ones in the aspects of the objective criterion, comprehensive definition, and practical application.
Construction of Customized Palatal Orthodontic Devices on Skeletal Anchorage Using Biomechanical Modeling
Authors: Suetenkov Dmitriy , Ivanov Dmitriy , Dol Aleksandr , Diachkova Ekaterina , Vasil’ev Yuriy , Kossovich Leonid
Published: January 2022

Orthodontic implants have been developed for the implementation of skeletal anchorage and are effectively used in the design of individual orthodontic devices. However, despite a significant amount of clinical research, the biomechanical aspects of the use of skeletal anchorage have not been adequately studied. The aim of this work was to numerically investigate the stress–strain state of the developed palatal orthodontic device supported by mini-implants. Four possible options for the placement of mini-implants in the bone were analyzed. The effect of a chewing load of 100 N on the bite plane was investigated. The study was carried out using biomechanical modeling based on the finite element method. The installation of the palatal orthodontic device fixed on mini-implants with an individual bite plane positioned on was simulated. The dependence of equivalent stresses and deformation changes on the number and location of the supporting mini-implants of the palatal orthodontic device was investigated. Two materials (titanium alloy and stainless steel) of the palatal orthodontic device were also investigated. The choice of a successful treatment option was based on the developed biomechanical criteria for assessing the surgical treatment success. Application of the criteria made it possible to estimate the stability and strength of fixation of each of the considered mini-implants installation options. As a result, options for the mini-implants optimal placement were identified (the first and the fourth which provide distributed front and side support of the device), as well as the preferred material (titanium alloy) for the manufacture of the palatal orthodontic device.
The Biological Effects of 3D Resins Used in Orthodontics: A Systematic Review
Authors: Francisco Inês , Paula Anabela Baptista , Ribeiro Madalena , Marques Filipa , Travassos Raquel , Nunes Catarina , Pereira Flávia , Marto Carlos Miguel , Carrilho Eunice , Vale Francisco
Published: January 2022

Three-dimensional (3D) resin medical-dental devices have been increasingly used in recent years after the emergence of digital technologies. In Orthodontics, therapies with aligners have gained popularity, mainly due to the aggressive promotion policies developed by the industry. However, their systemic effects are largely unknown, with few studies evaluating the systemic toxicity of these materials. The release of bisphenol A and other residual monomers have cytotoxic, genotoxic, and estrogenic effects. This systematic review aims to analyze the release of toxic substances from 3D resins used in Orthodontics and their toxic systemic effects systematically. The PICO question asked was, “Does the use of 3D resins in orthodontic devices induce cytotoxic effects or changes in estrogen levels?”. The search was carried out in several databases and according to PRISMA guidelines. In vitro, in vivo, and clinical studies were included. The in vitro studies’ risk of bias was assessed using the guidelines for the reporting of pre-clinical studies on dental materials by Faggion Jr. For the in vivo studies, the SYRCLE risk of bias tool was used, and for the clinical studies, the Cochrane tool. A total of 400 articles retrieved from the databases were initially scrutinized. Fourteen articles were included for qualitative analysis. The risk of bias was considered medium to high. Cytotoxic effects or estrogen levels cannot be confirmed based on the limited preliminary evidence given by in vitro studies. Evidence of the release of bisphenol A and other monomers from 3D resin devices, either in vitro or clinical studies, remains ambiguous. The few robust results in the current literature demonstrate the absolute need for further studies, especially given the possible implications for the young patient’s fertility, which constitutes one of the largest groups of patients using these orthodontic devices.
Molecular Characterization and Functional Localization of a Novel SUMOylation Gene in Oryza sativa
Authors: Ibrahim Eid I. , Attia Kotb A. , Ghazy Abdelhalim I. , Itoh Kimiko , Almajhdi Fahad N. , Al-Doss Abdullah A.
Published: January 2022

Small ubiquitin-related modifier (SUMO) regulates the cellular function of diverse proteins through post-translational modifications. The current study defined a new homolog of SUMO genes in the rice genome and named it OsSUMO7. Putative protein analysis of OsSUMO7 detected SUMOylation features, including di-glycine (GG) and consensus motifs (ΨKXE/D) for the SUMOylation site. Phylogenetic analysis demonstrated the high homology of OsSUMO7 with identified rice SUMO genes, which indicates that the OsSUMO7 gene is an evolutionarily conserved SUMO member. RT-PCR analysis revealed that OsSUMO7 was constitutively expressed in all plant organs. Bioinformatic analysis defined the physicochemical properties and structural model prediction of OsSUMO7 proteins. A red fluorescent protein (DsRed), fused with the OsSUMO7 protein, was expressed and localized mainly in the nucleus and formed nuclear subdomain structures. The fusion proteins of SUMO-conjugating enzymes with the OsSUMO7 protein were co-expressed and co-localized in the nucleus and formed nuclear subdomains. This indicated that the OsSUMO7 precursor is processed, activated, and transported to the nucleus through the SUMOylation system of the plant cell.
Can Type of Instrumentation and Activation of the Final Irrigant Improve the Obturation Quality in Oval Root Canals? A Push-Out Bond Strength Study
Authors: Pawar Ajinkya M. , Kfir Anda , Metzger Zvi , Bhardwaj Anuj , Yohana Yeyen , Wahjuningrun Dian Agustin , Luke Alexander Maniangat , Pawar Bhaggyashri A.
Published: January 2022

To appraise the outcome of file systems and activation of the final irrigant on the push-out bond strength of root fillings in oval canals. Single-rooted mandibular premolars (n = 180) with oval canals were divided into three groups (n = 60) for instrumentation: ProTaper Next (PTN), WaveOne (WO), and Self-adjusting File (SAF). The specimens were further divided into subgroups (n = 20) and subjected to final irrigation with activation by EndoActivator or passive ultrasonic irrigation or without activation. Then, the specimens were again subdivided (n = 10) and obturated with gutta-percha and AH Plus (GP-AH) or C-Point with EndoSequence bioceramic sealer (C-EBC). One-millimeter-thick horizontal slices were cut from the apical third of the root, 5 mm from the apex, and subjected to push-out bond strength (BS) testing. Specimens for which SAF was used exhibited higher BS values than those for which PTN or WO was used (p < 0.05). Activation of the final irrigation did not affect the BS of the root fillings. Root fillings made of C-EBC presented a higher BS than those made of GP-AH (p < 0.05). Adhesive failure was more common with specimens instrumented using PTN and WO. Root canals instrumented with SAF, showed the highest bond strength values for both root filling materials. The C-EBC produced significantly higher bond strength values than those of the GP-AH.
Psychological Symptoms in COVID-19 Patients: Insights into Pathophysiology and Risk Factors of Long COVID-19
Authors: Thye Angel Yun-Kuan , Law Jodi Woan-Fei , Tan Loh Teng-Hern , Pusparajah Priyia , Ser Hooi-Leng , Thurairajasingam Sivakumar , Letchumanan Vengadesh , Lee Learn-Han
Published: January 2022

There is growing evidence of studies associating COVID-19 survivors with increased mental health consequences. Mental health implications related to a COVID-19 infection include both acute and long-term consequences. Here we discuss COVID-19-associated psychiatric sequelae, particularly anxiety, depression, and post-traumatic stress disorder (PTSD), drawing parallels to past coronavirus outbreaks. A literature search was completed across three databases, using keywords to search for relevant articles. The cause may directly correlate to the infection through both direct and indirect mechanisms, but the underlying etiology appears more complex and multifactorial, involving environmental, psychological, and biological factors. Although most risk factors and prevalence rates vary across various studies, being of the female gender and having a history of psychiatric disorders seem consistent. Several studies will be presented, demonstrating COVID-19 survivors presenting higher rates of mental health consequences than the general population. The possible mechanisms by which the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters the brain, affecting the central nervous system (CNS) and causing these psychiatric sequelae, will be discussed, particularly concerning the SARS-CoV-2 entry via the angiotensin-converting enzyme 2 (ACE-2) receptors and the implications of the immune inflammatory signaling on neuropsychiatric disorders. Some possible therapeutic options will also be considered.
The Effects of Cranial Orientation on Forensic Frontal Sinus Identification as Assessed by Outline Analyses
Authors: Butaric Lauren N. , Richman Allison , Garvin Heather M.
Published: January 2022

The utility of frontal sinuses for personal identification is widely recognized, but potential factors affecting its reliability remain uncertain. Deviations in cranial position between antemortem and postmortem radiographs may affect sinus appearance. This study investigates how slight deviations in orientations affect sinus size and outline shape and potentially impact identification. Frontal sinus models were created from CT scans of 21 individuals and digitally oriented to represent three clinically relevant radiographic views. From each standard view, model orientations were deviated at 5° intervals in horizontal, vertical, and diagonal (e.g., left-up) directions (27 orientations per individual). For each orientation, sinus dimensions were obtained, and outline shape was assessed by elliptical Fourier analyses and principal component (PC) analyses. Wilcoxon sign rank tests indicated that sinus breadth remained relatively stable (p > 0.05), while sinus height was significantly affected with vertical deviations (p < 0.006). Mann–Whitney U tests on Euclidean distances from the PC scores indicated consistently lower intra- versus inter-individual distances (p < 0.05). Two of the three orientations maintained perfect (100%) outline identification matches, while the third had a 98% match rate. Smaller and/or discontinuous sinuses were most problematic, and although match rates are high, practitioners should be aware of possible alterations in sinus variables when conducting frontal sinus identifications.
Cognitive Phenotypic Plasticity: Environmental Enrichment Affects Learning but Not Executive Functions in a Teleost Fish, Poecilia reticulata
Authors: Montalbano Giulia , Bertolucci Cristiano , Lucon-Xiccato Tyrone
Published: January 2022

Many aspects of animal cognition are plastically adjusted in response to the environment through individual experience. A remarkable example of this cognitive phenotypic plasticity is often observed when comparing individuals raised in a barren environment to individuals raised in an enriched environment. Evidence of enrichment-driven cognitive plasticity in teleost fish continues to grow, but it remains restricted to a few cognitive traits. The purpose of this study was to investigate how environmental enrichment affects multiple cognitive traits (learning, cognitive flexibility, and inhibitory control) in the guppy, Poecilia reticulata. To reach this goal, we exposed new-born guppies to different treatments: an enrichment environment with social companions, natural substrate, vegetation, and live prey or a barren environment with none of the above. After a month of treatment, we tested the subjects in a battery of three cognitive tasks. Guppies from the enriched environment learned a color discrimination faster compared to guppies from the environment with no enrichments. We observed no difference between guppies of the two treatments in the cognitive flexibility task, requiring selection of a previously unrewarded stimulus, nor in the inhibitory control task, requiring the inhibition of the attack response toward live prey. Overall, the results indicated that environmental enrichment had an influence on guppies’ learning ability, but not on the remaining cognitive functions investigated.