bluuebunny/crossref_metadata_2025 huggingface dataset:
Analog Replicator of Long Chaotic Radio Pulses for Coherent Processing
Authors: Kuzmin Lev , Efremova Elena , Vladyka Pavel , Itskov Vadim
Published: December 2024

The relative structural simplicity of chaotic oscillators and the possibility of obtaining signals with a large dimension is of great interest for wireless data transmission and processing. The diversity of signal waveforms from the same source of chaos is provided by a fundamental property of chaotic oscillations: sensitivity to the choice of initial conditions. In this paper, this sensitivity is employed in the proposed method for forming analog chaotic radio pulses of arbitrary (specified) duration using an analog oscillator in such a way that the pulse shape can be changed and repeated from pulse to pulse. To repeat the shape of oscillations for an arbitrarily long period of time is not a problem for digital chaotic oscillators, but for analog systems, this is a challenge due to the impossibility of controlling the initial conditions and the evolution of the analog trajectory. In this paper, a new method for generating chaos is proposed, which can both change and repeat the shape of a chaotic signal of arbitrary duration, i.e., long chaotic radio pulses. The generator acts as a reservoir and as a replicator from which, under external influence, a signal of a certain shape can be extracted, and this shape can be reproduced. The term “long” in this case means that the duration of chaotic radio pulses is many times greater than the characteristic time of divergence of chaotic trajectories. To prove the correctness of the proposed generation method, the results of its experimental implementation in the frequency range of 100 to 500 MHz are given. Examples of forming equal pulses with a duration of about 20 to 200 quasi-periods of oscillations (up to 500 ns) are given. The proposed method provides the technical possibility of forming pulses whose dimensions can vary in a wide range, which is important for implementing large processing gains in various wireless applications. The method can be implemented in various frequency ranges in the class of analog generators of chaotic oscillations, since the employed generation method, i.e., modulation of a transistor generator by supply voltage, is natural for radio engineering.
Exploration of Quantum Chemistry Methods to Explain Mechanism of Mechanochemical Degradation of Typical Organic Pollutants
Authors: Zhang Xiaohui , Xu Xiaoqian , Zhang Zeya , Pei Liang , Han Tongshun
Published: December 2024

The high-efficiency ball milling treatment technology primarily combines the excitation of oxidation processes with high-speed physical collisions, thereby promoting the reaction processes and enhancing the degradation effectiveness of materials. This technology has gained widespread attention in recent years for its application in the degradation of organic solid chemical pollutants. In this study, quantum chemical density functional theory (DFT) was employed to first analyze the impact of electron addition and subtraction on molecular chemical bonds. The molecular energies of the target pollutants and their possible intermediates were then calculated, and the theoretical energies required for the degradation pathways of the target organic compounds under oxidative-enhanced ball milling were computed. This further validated the accuracy of the ball milling experimental results. The theoretical energy required for the complete mineralization of solid organic chemicals through ball milling degradation was calculated, with values of 16,730.74 kJ/mol for lindane, 20,162.46 kJ/mol for tetrabromobisphenol A, 10,628.04 kJ/mol for sulfamethoxazole, and 4867.99 kJ/mol for trimethoprim. By combining different ball milling experimental conditions, the theoretical reaction time required for the complete mineralization of the target organic chemicals can be calculated. The comparison of theoretical calculations with the experimental results provides new insights into the ball milling degradation process and degradation pathways of the target pollutants.
RETRACTED: Di Paola et al. Combined Toxicity of Xenobiotics Bisphenol A and Heavy Metals on Zebrafish Embryos (Danio rerio). Toxics 2021, 9, 344
Authors: Di Paola Davide , Capparucci Fabiano , Lanteri Giovanni , Cordaro Marika , Crupi Rosalia , Siracusa Rosalba , D’Amico Ramona , Fusco Roberta , Impellizzeri Daniela , Cuzzocrea Salvatore , Spanò Nunziacarla , Gugliandolo Enrico , Peritore Alessio Filippo
Published: December 2024

The journal retracts the article entitled “Combined Toxicity of Xenobiotics Bisphenol A and Heavy Metals on Zebrafish Embryos (Danio rerio)” [...]
Volumetric Absorptive Microsampling in Toxicology
Authors: Pires Bruno , Catarro Gonçalo , Soares Sofia , Gonçalves Joana , Rosado Tiago , Barroso Mário , Araujo André R. T. S. , Gallardo Eugenia
Published: December 2024

Volumetric absorptive microsampling (VAMS) is an emerging technique in clinical and forensic toxicology. It is recognized as a promising alternative to traditional sampling methods, offering an accurate and minimally invasive means of collecting small volumes of biological samples, such as blood, urine, and saliva. Unlike conventional methods, VAMS provides advantages in terms of sample stability, storage, and transportation, as it enables samples to be collected outside laboratory environments without requiring refrigeration. This review explores several VAMS methodologies, with a particular focus on its application for the quantification of drugs and other substances in clinical and forensic toxicology. It compares VAMS to other microsampling techniques, such as dried blood spots (DBSs), highlighting VAMS’s superiority in addressing issues related to sample volume consistency and environmental impact. Despite its advantages, VAMS also presents certain limitations, including higher costs and difficulties in detecting underfilled samples. Overall, VAMS stands out as a microsampling technique with the potential to enhance patient compliance and operational efficiency, positioning itself as a viable tool for toxicological analysis in both clinical and forensic contexts.
Considerations and Challenges for Acute Inhalation Toxicity Testing and Classification of Zinc Sulphide Under REACH
Authors: Bruer Gustav Gerd , Lombaert Noömi , Burzlaff Arne , Spirlet Christine , Gödecke Daria , Ramazanoglu Mehmet , Creutzenberg Otto
Published: December 2024

Zinc sulphide is a widely used inorganic powder, and its production has reached quantities greater than 1000 t/year. Therefore, in accordance with OECD guideline 436, an acute inhalation test was implemented to provide more accurate data. This study is crucial for ensuring the safety of workers exposed to zinc sulphide dust and complying with regulatory requirements for REACH. Due to particle-specific properties, the maximum attainable concentration of zinc sulphide for an inhalation study was not certain. Two dry dispersion systems were used to aerosolize the zinc sulphide powder, and the generated aerosol was supplied to a nose-only inhalation exposure system. The results showed a maximum attainable concentration of 0.82 mg/L at an MMAD of 1.5 µm over a 4 h exposure. In the inhalation study, all six rats showed no specific symptoms and good health status and survived a post-exposure observation period of up to 14 days. From the results observed, the status of Not classified was derived according to CLP. Based on the experimental results, an LC50 was not determined but is considered to be higher than 0.82 mg/L (the maximum achievable aerosol concentration). These findings highlight the importance of documenting efforts to achieve aerosol conditions when concentrations required by OECD test guidelines cannot be reached.
Assessing the Acceptability and Feasibility of Five Cycles of Seasonal Malaria Chemoprevention in Côte d’Ivoire
Authors: Kangah Orphée , Zongo Issaka , Haro Alassane , Yavo William
Published: December 2024

Seasonal malaria chemoprevention (SMC) is a strategy recommended by the World Health Organization for children aged 3–59 months in the Sahel and sub-Sahel regions where malaria transmission is seasonal. In Côte d’Ivoire, malaria remains a high priority and accounts for the majority of consultations and deaths in children under five. The recent revision of the criteria for the introduction of seasonal malaria chemoprevention has made the north of Côte d’Ivoire, where malaria transmission is seasonal, eligible for the SMC. We conducted a pilot study in this part of the country to assess the acceptability and feasibility of five cycles of SMC in 1701 children. Seasonal malaria chemoprevention with sulfadoxine–pyrimethamine + amodiaquine (SP + AQ) was administered monthly to eligible children over five months. A qualitative approach and quantitative surveys were used to assess the strategy acceptability and feasibility in the study area. Overall, there was a positive perception, attitude, and adherence towards the seasonal malaria chemoprevention in this study area.
Rooftop Photovoltaic for Residential Electricity Self-Sufficiency: Assessing Potential Benefits in Major Japanese Cities
Authors: Dumlao Samuel Matthew G. , Yan Chuyue , Ogata Seiichi
Published: December 2024

Rooftop photovoltaic (RTPV) systems have the potential to significantly boost residential electricity self-sufficiency in urban areas. However, estimating the self-sufficiency potential of each city is challenging due to the trade-off between target accuracy and data availability, which limits the scalability of existing methods. This study aims to evaluate the potential of RTPV systems to enhance residential electricity self-sufficiency in major Japanese cities. The self-sufficiency analysis employs a balanced approach using statistical data to estimate RTPV and battery storage capacity in detached houses and hourly simulations to capture supply–demand variations. To project the penetration rate, a logistic curve is utilized to estimate the timeline for achieving a 100% installation rate in detached houses. The analysis reveals that RTPV systems could supply approximately 40% of the residential electricity demand in major cities, with some achieving self-sufficiency rates exceeding 65%. Densely populated cities like Tokyo, Osaka, and Kawasaki may only meet a quarter of their demand due to higher energy requirements. Including older detached houses in RTPV deployment boosted self-sufficiency by an average of 11.77%, with cities like Nagoya, Kyoto, and Kitakyushu achieving increases of 15–20%. Battery storage plays a critical role in enhancing self-sufficiency and reducing energy curtailment. Logistic curve projections suggest that most cities are unlikely to reach 100% RTPV penetration before 2050, though leading cities could achieve 75% penetration by then due to favorable growth rates. These findings reveal that while RTPV has substantial potential to improve residential electricity self-sufficiency, additional efforts are necessary to accelerate adoption. Further research is needed to refine capacity estimates, explore the socioeconomic and political context of the cities, and examine alternative pathways for cities like Tokyo, Osaka, and Kawasaki.
Mucosal Immunization with an Influenza Vector Carrying SARS-CoV-2 N Protein Protects Naïve Mice and Prevents Disease Enhancement in Seropositive Th2-Prone Mice
Authors: Sergeeva Mariia V. , Vasilev Kirill , Romanovskaya-Romanko Ekaterina , Yolshin Nikita , Pulkina Anastasia , Shamakova Daria , Shurygina Anna-Polina , Muzhikyan Arman , Lioznov Dmitry , Stukova Marina
Published: December 2024

Background/Objectives: Intranasal vaccination enhances protection against respiratory viruses by providing stimuli to the immune system at the primary site of infection, promoting a balanced and effective response. Influenza vectors with truncated NS1 are a promising vaccine approach that ensures a pronounced local CD8+ T-cellular immune response. Here, we describe the protective and immunomodulating properties of an influenza vector FluVec-N carrying the C-terminal fragment of the SARS-CoV-2 nucleoprotein within a truncated NS1 open reading frame. Methods: We generated several FluVec-N recombinant vectors by reverse genetics and confirmed the vector’s genetic stability, antigen expression in vitro, attenuation, and immunogenicity in a mouse model. We tested the protective potential of FluVec-N intranasal immunization in naïve mice and seropositive Th2-prone mice, primed with aluminium-adjuvanted inactivated SARS-CoV-2. Immune response in immunized and challenged mice was analyzed through serological methods and flow cytometry. Results: Double intranasal immunization of naïve mice with FluVec-N reduced weight loss and viral load in the lungs following infection with the SARS-CoV-2 beta variant. Mice primed with alum-adjuvanted inactivated coronavirus experienced substantial early weight loss and eosinophilia in the lungs during infection, demonstrating signs of enhanced disease. A single intranasal boost immunization with FluVec-N prevented the disease enhancement in primed mice by modulating the local immune response. Protection was associated with the formation of specific IgA and the early activation of virus-specific effector and resident CD8+ lymphocytes in mouse lungs. Conclusions: Our study supports the potential of immunization with influenza vector vaccines to prevent respiratory diseases and associated immunopathology.
SARS-CoV-2 Evolution: Implications for Diagnosis, Treatment, Vaccine Effectiveness and Development
Authors: Angius Fabrizio , Puxeddu Silvia , Zaimi Silvio , Canton Serena , Nematollahzadeh Sepehr , Pibiri Andrea , Delogu Ilenia , Alvisi Gualtiero , Moi Meng Ling , Manzin Aldo
Published: December 2024

The COVID-19 pandemic, driven by the rapid evolution of the SARS-CoV-2 virus, presents ongoing challenges to global public health. SARS-CoV-2 is characterized by rapidly evolving mutations, especially in (but not limited to) the spike protein, complicating predictions about its evolutionary trajectory. These mutations have significantly affected transmissibility, immune evasion, and vaccine efficacy, leading to multiple pandemic waves with over half a billion cases and seven million deaths globally. Despite several strategies, from rapid vaccine development and administration to the design and availability of antivirals, including monoclonal antibodies, already having been employed, the persistent circulation of the virus and the emergence of new variants continue to result in high case numbers and fatalities. In the past four years, immense research efforts have contributed much to our understanding of the viral pathogenesis mechanism, the COVID-19 syndrome, and the host–microbe interactions, leading to the development of effective vaccines, diagnostic tools, and treatments. The focus of this review is to provide a comprehensive analysis of the functional impact of mutations on diagnosis, treatments, and vaccine effectiveness. We further discuss vaccine safety in pregnancy and the implications of hybrid immunity on long-term protection against infection, as well as the latest developments on a pan-coronavirus vaccine and nasal formulations, emphasizing the need for continued surveillance, research, and adaptive public health strategies in response to the ongoing SARS-CoV-2 evolution race.
Attitudes Toward General Vaccination Mediate the Association Between Influenza Vaccination History and Pneumococcal Vaccination Intention Among Older Adults in China
Authors: Huang Siwen , Ruan Chi , Jiang Yan , Song Yudan , Zhang Yuhang , Qin Zeying , Shi Xinyu , Zhang Mengyue , Zhou Jingtao , Chen Dingwan , Xiao Yongkang , Wang Liang , Tian Lili , Peng Rui , Peng Zongchao , Luo Sitong
Published: December 2024

Background: Influenza and pneumococcal vaccinations play a crucial role in disease prevention among older adults and are recommended to older adults aged 60 years and over in China, but the vaccination rates are suboptimal. Behavioral spillover indicates that a change in one behavior may lead to changes in other related behaviors. Objective: Based on the Behavioral Spillover Theory, this study aimed to investigate the association between influenza vaccination history and pneumococcal vaccination intention, as well as the mediating role of negative attitudes toward general vaccination among older adults in China. Method: A multi-center cross-sectional survey was conducted among 1031 older adults, and 658 participants (median age: 65.0 ± 9.0 years) who had not received pneumococcal vaccination were included in the analysis. Correlation analysis and path analysis were performed. Results: A significant positive association was observed between influenza vaccination history and pneumococcal vaccination intention (r = 0.167, p < 0.001). In contrast, negative attitudes toward general vaccination, including mistrust of vaccine benefits (r = −0.253, p < 0.001), worries about unforeseen future effects (r = −0.180, p < 0.001), concerns about commercial profiteering (r = −0.360, p < 0.001), and a preference for natural immunity (r = −0.212, p < 0.001) were negatively associated with pneumococcal vaccination intention. Negative attitudes toward general vaccination mediated the association between influenza vaccination history and pneumococcal vaccination intention (total indirect effect = 0.119, p < 0.001, effect size = 50.0%). Conclusion: These findings demonstrated that influenza vaccination history may reduce negative attitudes toward general vaccination, which may further increase pneumococcal vaccination intention, indicating spillover effects of influenza vaccination history. To promote vaccination behavior among older adults, addressing negative attitudes toward general vaccination is crucial.
Optimizing Microneutralization and IFN-γ ELISPOT Assays to Evaluate Mpox Immunity
Authors: Yu Yinyi , Meza Krystal , Colbert Chase , Hoft Daniel F. , Jaunarajs Anna , Blazevic Azra , Frey Sharon E. , Abate Getahun
Published: December 2024

Background: Available assays to measure pox virus neutralizing antibody titers are laborious and take up to 5 days. In addition, assays to measure T cell responses require the use of specific antigens, which may not be the same for all pox viruses. This study reports the development of robust assays for the measurement of mpox-specific neutralizing antibodies and IFN-γ-producing T-cell responses. Methods: Fourteen samples from 7 volunteers who received Modified Vaccinia Ankara-Bavarian Nordic (MVA-BN) were used. The focused reduction neutralization test (FRNT) was performed using the mpox-specific A29 monoclonal antibody. Optimization and further development of FRNT were conducted using the plaque reduction neutralization test (PRNT) as the gold standard. The mpox-specific IFN-γ ELISPOT assay was optimized using different mpox antigen preparations. Results with pre-vaccination samples were compared with post-vaccination samples using the Wilcoxon matched-pairs test. Results: Pre-vaccination and post-vaccination sera (n = 7) had FRNT50 (i.e., titers that inhibited at least 50% of the virus) of 109.1 ± 161.8 and 303.7 ± 402.8 (mean ± SD), respectively. Regression analysis of fold changes in FRNT50 and PRNT50 showed that the two assays closely agree (n = 25 tests on paired samples, R2 of 0.787). Using UV-inactivated mpox as an antigen, the number of IFN-γ spot-forming T cells (SFC) in pre-vaccination samples (16.13 ± 15.86, mean ± SD) was significantly lower than SFC in post-vaccination samples (172.9 ± 313.3, mean ± SD) with p = 0.0078. Conclusions: Our newly developed microneutralization test has a good correlation with PRNT. UV-inactivated mpox is an appropriate antigen for the ELISPOT assay that measures mpox cross-reactive T cells. These assays will be useful in future mpox vaccine studies.
A Review of Intermittent Poisoning to Mitigate Toxic Plant-Induced Disease in Livestock
Authors: Stegelmeier Bryan L. , David T. Zane , Panter Kip E. , Welch Kevin D. , Knoppel Edward L.
Published: December 2024

Poisonous plants affect livestock and wildlife and in addition to animal disease, they often inhibit the productive use of feeds and natural resources. For some plants, intermittent or cyclic grazing may allow the use of contaminated forages or infested pastures or ranges while avoiding permanent effects of poisoning. The objective of this review is to present several toxic plants for which intermittent poisoning might be an effective management tool. Additionally, as intermittent exposures present risks, those risks will be discussed, and signs of impending problems identified. Additional plants that mechanistically have potential for becoming less problematic via intermittent exposure will also be discussed. Lastly, toxic plants to which any exposure causes permanent or fatal damage or those that might result in cumulative damage with repeated exposures will also be discussed.
Kariyer Keşif ve Kararı Öğrenme Deneyimleri Ölçeğinin Türk Kültürüne Uyarlanması
Authors: Çoğalan Yılmaz , Yazıcı Hikmet
Published: December 2024

Bireylerin hayatları boyunca karar aşamasından geçtikleri önemli dönüm noktaları vardır. Bu aşamalar bireylere birçok deneyim ve öğrenme sağlayarak geleceğe ışık tutmaktadır. Bu bağlamda çalışmanın amacı kariyer seçim sürecinden geçmiş olan bireylerin deneyimlerini belirlemek amacıyla geliştirilen Kariyer Keşif ve Kararı Öğrenme Deneyimleri Ölçeği'nin (KKKÖDÖ) Türk kültüründeki geçerlik ve güvenirlik çalışmalarının yapılmasıdır. Çalışmaya üniversite 1. ve 2. sınıfta öğrenim gören 412 öğrenci katılmıştır. Açımlayıcı (AFA) ve doğrulayıcı (DFA) faktör analizleri için veriler rastgele ikiye ayrılmıştır (AFA=206, DFA=206). Yapılan AFA neticesinde ölçeğin orjinalinde de olduğu gibi dört faktörlü yapı elde edilmiştir. Ardından hem oluşan dört faktörlü yapı hem de kuramsal çerçeve gereği beş faktörlü yapı için DFA yapılmış ve beş faktörlü yapının daha iyi uyum indeksleri sağladığı bulunmuştur (X2/df=1.48, RMSEA= .048, RMR= .065, CFI= .94, GFI= .90, AGFI= .87). Bununla birlikte ölçüt geçerliği kapsamında yapılan analizler sonucunda Kariyer Kararı Yetkinlik Beklentisi Ölçeği (Işık, 2010) ile faktörlerden Kişisel Performanslar (KP) arasında .579, Sosyal İkna (Sİ) ile arasında .572, Dolaylı Öğrenme (DÖ) ile arasında .419, Pozitif Duygusal Uyarılma (PDU) ile arasında .482 değerlerinde pozitif yönlü ilişki bulunmuşken Negatif Duygusal Uyarılma (NDU) ile arasında -.290 değerinde negatif yönlü ilişki bulunmuştur. Güvenirlik analizi kapsamında hesaplanan Cronbach Alpha iç tutarlık katsayısı AFA örneklemi için .75 ile .85 arasında, DFA örneklemi için .70 ile .81 arasında değişmektedir. İki yarı test yöntemiyle hesaplanan güvenirlik katsayısı değerleri AFA örneklemi için .78 ile .89 arasında, DFA örneklemi için .71 ile .86 arasında değişmektedir. Elde edilen sonuçlar KKKÖDÖ'nün Türk kültürü için geçerli ve güvenilir olduğunu göstermektedir.
Teachers’ Understanding in the Implementation of Project Based Learning (PjBL) Model in ‘Kurikulum Merdeka’
Authors: Susila Heni Rita , Sutiono Edi , Putri Anisya Julia
Published: December 2024

The purpose of this study was to determine the understanding of vocational high school teachers regarding the implementation of project-based learning models or known as project based learning (PjBL). The PjBL model has become an important part of the independent curriculum because this learning model is closely related to the concept of independent learning to provide flexibility to students. This learning model is also one of the learning models recommended for use in the independent curriculum. This research was conducted by distributing questionnaires to collect information about teachers' understanding of the PjBL model. The respondents of this study were 64 vocational high school teachers. The data was analyzed quantitatively using percentages. Researchers collected information using indicators from front-end analysis introduced by Lee Owen. These indicators are audience analysis, technology analysis, critical-incident analysis and media analysis. The highest score with a percentage of 87% stated that teachers wanted to develop a video-based media that simulated the implementation of the project based learning (PjBL) learning model.
Analisis Kerjasama Internasional dalam Membangun IKN: Bentuk, Fokus dan Kepentingan
Authors: Setiawan Asep , Usni Usni , Surwandono Surwandono , Mediana Dina , Syakban Mansyur
Published: December 2024

Studi ini menganalisis kerja sama internasional, baik bilateral maupun multilateral, dalam pembangunan ibu kota baru Indonesia, Ibu Kota Nusantara (IKN). Studi ini menggunakan kerangka teori kerja sama internasional dan kepentingan nasional untuk melihat dinamika yang melandasi kemitraan tersebut. Metodologi penelitian kualitatif digunakan, dengan memakai data yang diperoleh dari tinjauan literatur dan wawancara. Hasilnya menunjukkan tiga temuan utama. Pertama, kerja sama di seluruh dunia dalam proyek IKN merupakan sebuah bentuk komitmen yang menggabungkan badan-badan pemerintah, sektor korporasi, dan lembaga-lembaga global. Interaksi ini dapat diklasifikasikan ke dalam bentuk kerja sama bilateral dan multilateral. Kedua, kerja sama Indonesia dengan mitra dari Asia dan Eropa berfokus pada dua bidang utama: pembangunan infrastruktur dan proyek pembangunan berkelanjutan ramah lingkungan. Negara-negara Asia memiliki ketertarikan yang besar terhadap proyek-proyek infrastruktur, sementara mitra-mitra dari Eropa menekankan pada inisiatif-inisiatif ramah lingkungan dalam pembangunan ibu kota baru. Ketiga, terlepas dari partisipasi mereka dalam IKN, tujuan ekonomi dan politik dari mitra Indonesia baik dari Asia maupun Eropa tampaknya melampaui inisiatif untuk kerja sama tersebut. Kepentingan nasional mereka adalah untuk meningkatkan hubungan politik dan ekonomi dengan Indonesia, yang sering kali menekankan investasi di sektor-sektor seperti pertambangan dan infrastruktur di luar wilayah Kalimantan. Studi ini meningkatkan diskusi akademis mengenai pola dan modalitas kerja sama internasional di Indonesia, memberikan wawasan tentang motivasi strategis mitra Indonesia di seluruh dunia terkait proyek IKN. 
Kata kunci — Bilateral, Ibu kota baru, Internasional, Kepentingan nasional, Kerjasama, Multilateral
Percepción de los usuarios adultos mayores sobre la calidad de atención de salud en una comuna de la región de los ríos, Chile, post pandemia
Authors: Tauda Mauro ernesto , Cruzat Bravo Eduardo Joel , Lopez molina Efrain
Published: December 2024

Objetivos: El presente estudio tiene como objetivo determinar la percepción de los usuarios adultos mayores sobre la calidad de atención de salud en una comuna de la Región de Los Ríos, Chile. Post pandemia.Materiales y métodos: A treves de un muestreo no probabilístico, de inclusión por conveniencia, 30 adultos mayores de La región de los ríos serán parte del estudio. Se realizo una encuesta de percepción de las variables calidad de los servicios y satisfacción del usuario. A partir de 20 preguntas con 4 niveles de satisfacción 1. Muy desacuerdo. 2, Desacuerdo. 3. De acuerdo. 4. Muy de acuerdoResultados: Se puede concluir que existe una diversidad de opiniones y actitudes entre los usuarios adultos mayores con respecto a la calidad de atención Un 37% de los usuarios adultos mayores están muy de acuerdo con la calidad de atención, Un 33% de los usuarios adultos mayores están de acuerdo, un 20% de los usuarios adultos mayores expresan desacuerdo con la calidad de atención y un 10% de los usuarios adultos mayores están muy en desacuerdo con la calidad de atención en el sistema de salud.Conclusiones; No se detectaron diferencias con la prueba X2. Entre ambos sexos se observó entre las respuestas “grado de acuerdo” y “muy de acuerdo” en la mayoría de las preguntas alcanzando entre el 40% y 50% de las preferencias entre las cuatro categorías entre las preguntas.
An Analysis of Market Size Trends Forecasting and Range Prediction in Electric Vehicles Using Machine Learning Algorithms
Authors: Kaya Hakan
Published: December 2024

Electric vehicles face fundamental challenges primarily related to battery and charging systems. Conducting a market size analysis is an essential component of market research as it provides insights into the potential sales volume within a specific market. This study focuses on conducting a comprehensive analysis of market size within a EV industry segment, alongside predictions for the range. By leveraging data-driven approaches and predictive modelling techniques, insights into market dynamics and future trends are explored. The article contains 177866 data the task of performing a market size analysis for the Electric Vehicles sector using Python. Range estimation of the electric vehicle has been conducted using Linear, Random Forest, Ridge, Lasso, and Elastic Net Regression model types. When predicting range, performance metrics such as R-Squared, Adjusted R-Squared, Mean Squared Error, Root Mean Squared Error, and Mean Absolute Error are used, while Compound Annual Growth Rate (CAGR) is utilized for current and estimated EV market size. Based on the findings, the Tesla brand is predominantly preferred. A consistent annual growth rate of 51% has been noted. Random Forest Regression is identified as the premier model for predicting electric vehicle range due to its superior performance metrics, such as a higher R-Squared value and lower mean squared error in comparison to other regression methods.
Síndrome de Stevens-Johnson associada a necrólise epidérmica tóxica: um relato de caso
Authors: Zanotto Lourenço Duarte , Manfroi Carolina Pruner , Camargo Gabriele Schmitt
Published: December 2024

A síndrome de Stevens-Johnson (SSJ) e a necrólise epidérmica tóxica (NET) são reações cutâneas graves provocadas principalmente pelo uso de medicamentos, embora infecções, vacinas e causas idiopáticas também possam contribuir. A SSJ afeta menos de 10% da superfície da pele, enquanto a NET compromete mais de 30%, e a forma sobreposta abrange entre 10% e 30%. Ambas são emergências dermatológicas que exigem reconhecimento e tratamento precoces para evitar complicações fatais. O diagnóstico é clínico, mas exames histopatológicos podem ajudar a diferenciar de outras condições com apresentações semelhantes. O tratamento envolve suporte clínico intensivo, incluindo a retirada do medicamento causador, reposição de fluidos e eletrólitos, cuidados dermatológicos e prevenção de infecções secundárias por meio de limpeza e curativos. A taxa de mortalidade é de aproximadamente 25% para casos graves de SSJ e NET sobreposta, devido às complicações sistêmicas associadas. Este trabalho visa relatar um caso clínico de um jovem que desenvolveu SSJ e NET após o uso de medicação, destacando seu quadro clínico e o manejo adotado.
Desafios para a implementação dos cuidados paliativos frente ao cuidado multiprofissional
Authors: Araújo Nathana Ferreira de , Lameira Yara Costa , Sangale Giovanna Mitsuko , Araujo Rodrigo Augusto Raulino de , Freire Ana Luiza de Souza Albuquerque , Silva Miracelia dos Santos da , Costa Ruth Silva Lima da
Published: December 2024

Os cuidados paliativos têm como foco aliviar o sofrimento físico, emocional, social e espiritual de pacientes com doenças graves e incuráveis, além de oferecer suporte integral às suas famílias. Priorizando a qualidade de vida, esta abordagem abrange todas as fases da doença, independentemente da possibilidade de cura. Este estudo investiga os principais desafios na implementação dos cuidados paliativos, com ênfase no cuidado multiprofissional, por meio de uma revisão da literatura em plataformas como a Scientific Electronic Library Online (SciELO) e a National Library of Medicine's (PubMed). Os principais desafios incluem a falta de conhecimento dos profissionais de saúde e a escassez de serviços especializados. Reforça-se a necessidade de formação adequada e de uma abordagem multiprofissional para garantir cuidados abrangentes e de qualidade. Os cuidados paliativos são essenciais na assistência médica contemporânea, proporcionando alívio do sofrimento e qualidade de vida. Sua evolução demonstra uma mudança de paradigma, ampliando o foco da cura para uma abordagem holística que atende às necessidades integrais de pacientes e familiares.
Cuidados de enfermagem na prevenção da obesidade infantil na faixa etária de 0 a 5 anos
Authors: Alves Kelly Cristina de Souza Silva , Miranda Rosa Helena da Silva , Freitas Nathália Farias de
Published: December 2024

Atualmente muitas crianças estão inseridas em ambiente propenso a obesidade, nos quais há uma promoção do sedentarismo e uma alimentação pouco saudável, sendo assim é necessário um melhor conhecimento em saúde, dos pais, das crianças e toda comunidade sobre a obesidade. É importante que a enfermagem compreenda o contexto familiar da criança, identifique os desafios e auxilie na diminuição dos impactos da obesidade infantil. Trata-se de uma revisão de literatura com artigos publicados em português, inglês e espanhol nos anos de 2019 a 2024, utilizando os descritores em ciências da saúde e selecionados 8 artigos nas bases de dados Sistema Online de Busca e Análise de Literatura Médica (MEDLINE), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Enfermagem Index Psicologia (BDENF), Periódicos técnico-científicos, Índice Bibliográfico Español en Ciencias de la Salud (IBECS). Os autores destacam a alimentação saudável e prática regular de atividade física, o aleitamento materno e a educação dos pais como forma de prevenção para a obesidade infantil. O enfermeiro desempenha um papel essencial, não somente na promoção da educação da criança e cuidadores, sua assistência deve transcender âmbitos que alcance a educação das comunidades.
Neuroestimulador sacral como primeira opção cirúrgica em paciente com lesão esfincteriana após parto vaginal - relato de caso
Authors: Cardoso Lucas Alves Bessa , Fernandes Cristiane Koizimi Martos , Amaral Hélida Aline Tomacheski , Queiroz Fábio Lopes de , Pereira Bárbara Maria Tavares , Estrada Daniel Maurício Londoño
Published: December 2024

A incontinência fecal é uma condição debilitante que afeta a qualidade de vida, sendo frequentemente associada a traumas obstétricos. Este relato descreve o caso de uma paciente de 31 anos com incontinência urinária e fecal após parto vaginal complicado, resultando em laceração perineal grau IV. Inicialmente tratada com biofeedback, apresentou melhora parcial, mas sem controle satisfatório da incontinência. Após discussão multidisciplinar, optou-se pelo implante de neuroestimulador sacral. O procedimento, realizado por técnica rádio-assistida, demonstrou resposta adequada, com implante definitivo posicionado à esquerda. A paciente apresentou boa adaptação e permanece sem sintomas desde a cirurgia mostrando que o neuroestimulador sacral é uma opção viável como primeira linha cirúrgica
Efeitos da estimulação transcutânea do nervo vago na recuperação motora dos membros superiores em pacientes pós ataque vascular encefálico: uma revisão sistemática
Authors: Barros Sabrina Andressa Silva , Brito Paola Ribeiro , Silva Rebeca Abençoada Pereira da , Ody Gabriel Gonçalves dos Santos , Bilha Gustavo Feitoza , Sousa Ithalo Gomes Garcia , Albiero Lucineia Reuse
Published: December 2024

O acidente vascular encefálico (AVE) causa alta taxa de morte e incapacidade funcional, afetando a autonomia dos pacientes. A estimulação do nervo vago (VNS) é promissora na recuperação, mas exige cirurgia invasiva com possíveis efeitos adversos. Como alternativa, explora-se a estimulação transcutânea do nervo vago (taVNS), uma opção menos invasiva para a reabilitação pós-AVE. Este estudo, seguindo o protocolo PRISMA, identificou 350 artigos, dos quais 3 artigos foram selecionados para a revisão por se alinharem à temática e aos objetivos do trabalho. Os efeitos dos protocolos de VNS são avaliados com base em desfechos clínicos, como a pontuação na avaliação Fugl-Meyer do membro superior, o teste de função motora de Wolf, a Medida de Independência Funcional e a avaliação de Brunnstrom. Embora a taVNS tenha mostrado resultados positivos, são necessários mais estudos para determinar o protocolo ideal devido a limitações como amostras pequenas e falta de acompanhamento a longo prazo. A estimulação do nervo vago auricular ativada por motor também se mostrou eficaz na reabilitação motora pós-AVE, com menos custos e riscos que o VNS implantado. Além disso, mais pesquisas são necessárias para otimizar os tratamentos e avaliar a taVNS em diferentes fases do AVE.
دور محاسبة تكاليف الجودة في تحقيق التوازن الاستراتيجي بالقطاعات الصناعية: دراسة على (مصانع جياد) السودانية
Authors: عبدالله محمد إسحق
Published: December 2024

هدف الدراسة: هدفت الدراسة إلى إبراز أهمية محاسبة تكاليف الجودة وأثرها في تحقيق التوازن الاستراتيجي بالقطاعات الصناعية السودانية.تصميم/منهجية/طريقة الدراسة: اعتمدت الدراسة على قائمة استقصاء، تتضمن مجموعة من العبارات لقياس متغيرات الدراسة، واختبار فروضها؛ ومن ثم تحقيق أهدافها.عينة الدراسة وبياناتها: أجريت الدراسة الميدانية على عينة قصدية مكونة من 122 فردًا من العاملين في مصانع جياد السودانية..نتائج الدراسة: خلصت الدراسة إلى وجود علاقة معنوية تشير إلى دور محاسبة تكاليف الجودة في تحقيق التوازن الاستراتيجي في القطاعات الصناعية السودانية.أصالة الدراسة: لم تَربط أبعادَ تكاليف الجودة بأبعاد التوازن الاستراتيجي في الشركات الصناعية في الدراسات العربية والإنجليزية السابقة، بحسب علم الباحث.حدود الدراسة وتطبيقاتها: ركزت الدراسة على مجموعة محددة من المشاركين، شملت مديري الإدارات، ورؤساء الأقسام، والمحاسبين المرتبطين بموضوع البحث. تم تنفيذ جمع البيانات خلال فترة زمنية محددة استغرقت أربعة أشهر، واقتصرت الدراسة على متغيرين رئيسيين: تكاليف الجودة والتوازن الاستراتيجي.
Sürdürülebilir Binalar İçin Güneşlenme Süresinin 3B Modellenmesi ve Simülasyonu Üzerine Bir Araştırma
Authors: Uslu Ahmet , Tuğcu Abtullah
Published: December 2024

Güneşlenme süresi, insan sağlığı, tarım, çevre, ekosistem, iklim değişikliği, mimarlık ve güneş enerjisi alanındaki sürdürülebilirlik çalışmaları için önemli bir meteorolojik parametredir. Bu parametre, kentsel binaların güneş enerjisi potansiyelinin analizi için değerli bir veri kaynağıdır. Üç boyutlu (3B) sanal bina modelleri, kentsel planlama sürecinde güneş enerjisi çalışmalarını destekleyerek daha doğru ve görsel olarak net simülasyonlar sağlarlar. Bu çalışmada, Tavşanlı Fizik Tedavi ve Rehabilitasyon Hastanesi’nin 3B sanal modeli kullanılarak, kış ve yaz gündönümü (21 Aralık ve 21 Haziran) tarihleri ile ekinoks (21 Mart ve 23 Eylül) tarihlerinde binanın çatı ve cephe yüzeylerindeki güneşlenme süresinin mekânsal-zamansal analizi gerçekleştirilmiştir. Çalışma alanı içerisinde, en uzun güneşlenme süresinin yaz gündönümünde, en kısa güneşlenme süresinin kış gündönümünde gerçekleştiği, ilkbahar ve sonbahar ekinokslarında benzer güneş ışığı koşullarının yaşandığı tespit edilmiştir. Çalışma, kamu binalarının önemli bir bileşeni olan hastanelerde gelecekteki enerji tasarrufu tasarımlarına rehberlik etmek için gelişmiş 3B simülasyon araçlarını kullanarak sürdürülebilir kentsel planlama ve çevre koruma gibi daha geniş hedeflere katkıda bulunmaktadır.
THE IMPACT OF ASSET STRUCTURE, BUSINESS RISKS AND FIRM SIZE ON PROFITABILITY AND CAPITAL STRUCTURE OF PHARMACEUTICAL SUB-SECTOR COMPANIES ON THE INDONESIAN STOCK EXCHANGE PERIOD 2018-2022
Authors: Chandra Jennifer , Gwendolin Gwendolin , Chandra Teddy , Wijaya Evelyn
Published: December 2024

This research aims to analyze the effect of Asset Structure, Business Risk, and Firm size on Profitabillity and Capital Structure of pharmaceutical sub-sector companies. In this research, sampling was conducted using purposive sampling method. The samples used in this research were 10 companies out of a total of 12 pharmaceutical sub-sector companies. The data analysis technique used to analyze the data is multiple linear regression analysis. The results showed that asset structure, business risk, and Firm size has insignificant effect on the profitability and capital structure of pharmaceutical sub-sector companies. This research also shows that profitability does not mediate the relationship between asset structure, business risk, Firm size on capital structure.
Penelitian ini bertujuan untuk menganalisis pengaruh Struktur Aktiva, Risiko Bisnis, dan Ukuran Perusahaan terhadap Profitabilitas dan Struktur Modal pada perusahaan subsektor farmasi. Dalam penelitian ini pengambilan sampel dilakukan dengan menggunakan metode purposive sampling. Sampel yang digunakan dalam penelitian ini adalah 10 perusahaan dari total 12 perusahaan subsektor farmasi. Teknik analisis data yang digunakan untuk menganalisis data adalah analisis regresi linier berganda. Hasil penelitian menunjukkan bahwa struktur aset, risiko bisnis, dan ukuran perusahaan tidak berpengaruh signifikan terhadap profitabilitas dan struktur modal pada perusahaan subsektor farmasi. Penelitian ini juga menunjukkan bahwa profitabilitas tidak memediasi hubungan antara struktur aset, risiko bisnis, ukuran perusahaan terhadap struktur modal.
PENGARUH TATA KELOLA, PROFITABILITAS, LEVERAGE DAN UKURAN PERUSAHAAN TERHADAP PENGUNGKAPAN MANAJEMEN RISIKO PADA INDUSTRI KEUANGAN NON-BANK
Authors: Octavia Vivi , Nelly Ria , Haryadi Haryadi
Published: December 2024

This research aims to determine the effect of the audit committee, independent board of commissioners, board of commissioners, profitability, leverage, and company size on risk management disclosure in the Non-Bank Financial Industry listed on the Indonesia Stock Exchange (IDX) in 2017–2019. The population in this study is 39 Non-Bank Financial Industry listed on the Indonesia Stock Exchange (BEI) 2017-2019 so that from this population a sample of 33 companies was obtained using the purposive sampling method. The data analysis technique used in this research is multiple linear regression test. The results of this research declare that there is a significant relationship among audit committee, profitability, leverage and firm size on risk management disclosure, while the independent board of commissioners and the board of commissioners has no effect on risk management disclosure.
Penelitian ini bertujuan untuk menguji pengaruh komite audit, dewan komisaris independen, dewan komisaris, profitabilitas, leverage, dan ukuran perusahaan terhadap pengungkapan manajemen risiko pada Industri Keuangan Non-Bank yang terdaftar di Bursa Efek Indonesia (BEI) tahun 2017–2019. Populasi penelitian ini adalah 39 Industri Keuangan Non-Bank  yang terdaftar di Bursa Efek Indonesia (BEI) tahun 2017-2019 sehingga dari populasi tersebut diperoleh sampel sebanyak 33 perusahaan dengan menggunakan metode purposive sampling. Teknik analisis data yang digunakan dalam penelitian ini adalah uji regresi linear berganda. Hasil penelitian menunjukkan bahwa komite audit, profitabilitas, leverage dan ukuran perusahaan berpengaruh terhadap pengungkapan manajemen risiko, sedangkan dewan komisaris independen dan dewan komisaris tidak berpengaruh terhadap pengungkapan manajemen risiko.
Role of Media Exposure to Reduce Household Food Insecurity: A Case of a Rural Mountain Village in Nepal
Authors: Chuwan Nar Kumar
Published: December 2024

Extended Abstract
Pemberdayaan Masyarakat Melalui Pengembangan Keterampilan, Penguatan Kelembagaan, dan Peningkatan Partisipasi dalam Mempersiapkan Desa Wisata
Authors: Rianto Rianto , Octarina Dian , Nurmalinda Elda , Riyadi Agus
Published: December 2024

The purpose of this activity is to contribute positively to enhancing the capacity of the local community, both in knowledge and skills, so that they can manage agricultural potential as educational tourism attractions that benefit their economic and social well-being. The implementation methodology includes steps and strategies such as field research and in-depth interviews to identify local potential. Once the potential is identified, technical guidance is provided gradually and continuously to improve the community's capacity to manage agricultural potential into educational tourism attractions. These steps include training on processing agricultural products, marketing strategies, and developing sustainable tourism attractions. The results of the activity show an increase in the community's knowledge and skills in processing agricultural products such as tobacco, chilies, and melons into value-added products, such as souvenirs for visitors. The results and discussion of this activity also highlight the significant positive impact on the community's perspective regarding tourism potential, while also providing an analysis of the impact seen through the village's economic growth. This activity succeeded in changing the community's perspective on tourism potential and positively contributed to the development of the village as a tourism destination.
Pendampingan Pokdarwis untuk Merancang Media Interpretasi Paket Wisata Edukasi Bencana
Authors: Wulung Shandra Rama Panji , Hadian Mohammad Sapari Dwi , Yuliawati Ayu Krishna , Kikania Audy Putri , Abdilah Muhammad Anthesa
Published: December 2024

Peningkatan pemberdayaan mitra melalui pengetahuan dan keterampilan dalam menciptakan nilai tambah dan meningkatkan daya saing pariwisata di Desa Wisata Cikahuripan membutuhkan beberapa upaya yang tidak mudah. Namun upaya pendampingan perancangan media interpretasi dalam menunjang terwujudnya paket wisata edukasi bencana berpeluang memberikan solusi bagi permasalahan mitra. Tujuan kegiatan kajian ini adalah merancang media interpretasi dalam menunjang paket wisata edukasi bencana di Desa Wisata Cikahuripan, Kabupaten Bandung Barat. Metode kegiatan ini menggunakan Participatory Action Research (PAR) pada Pokdarwis Tjikahoeripan Gebied sebagai mitra sasaran dan didukung oleh PT. Katarda Indo Global sebagai mitra DUDI. Perolehan data melalui wawancara kepada mitra serta observasi dan dokumentasi untuk mendapatkan dalam merancang media interpretasi untuk paket wisata edukasi bencana. Data yang diperoleh selanjutnya dianalisis melalui metode kualitatif deskriptif dan analisis peta. Hasil kegiatan menunjukan media interpretasi yang mampu menunjang paket wisata edukasi bencana di Desa Wisata Cikahuripan dapat berupa buku panduan, poster, dan flyer. Media interpretasi memuat informasi mengenai profil daya tarik wisata di Desa Wisata Cikahuripan yang dilengkapi dengan rute geotrek dan peta sebaran daya tarik wisatanya. Efektivitas media interpretasi memberikan manfaat bagi wisatawan dalam memahami kondisi kepariwisatan dan kebencanaan di Desa Wisata Cikahuripan. Kegiatan ini berimplikasi bagi pengelola desa wisata di seluruh Indonesia dalam memanfaatkan media interpretasi sesuai dengan karakteristik wilayahnya, khusunya desa wisata yang masuk dalam kawasan rawan bencana alam
SUMBER DAYA INSANI DALAM MENINGKATKAN KUALITAS PELAYANAN
Authors: Sukma Fitri Mizani , Rahman Abd. , Jufri Muhammad
Published: December 2024

Human Resource Development, the potential to carry out an effort to improve and increase employee competence and performance which is one source of competitive advantage as the main and important key element in order to achieve success in competing and achieving goals. Service quality is one of the main tools for achieving the success of a company. Quality service is the existence of a service system that is oriented to the interests of customers or service users.
This type of research is field research with qualitative descriptive methods. This research uses two types of data sources, namely primary data and secondary data. The data collection techniques use interview, observation and documentation techniques.
From the research results, it can be seen that the analysis of human resource development strategies in improving the quality of service at Supermarket 1 Assyarif is to carry out Human Resources Management, Recruitment, Motivation, Development and Training, Maintaining Relationships and Work Atmosphere, Performance Assessment, and Compensation.