bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis and Evaluation of Acyl‐Chain‐ and Galactose‐6′′‐Modified Analogues of α‐GalCer for NKT Cell Activation
Authors: Hsieh Ming‐Han , Hung Jung‐Tung , Liw Ya‐Wen , Lu Yin‐Jen , Wong Chi‐Huey , Yu Alice L. , Liang Pi‐Hui
Published: June 2012

α‐GalCer is an immunostimulating glycolipid that binds to CD1d molecules and activates invariant natural killer T (iNKT) cells. Here we report a scaled‐up synthesis of α‐GalCer analogues with modifications in the acyl side chain and/or at the galactose 6′′‐position, together with their evaluation in vitro and in vivo. Analogues containing 11‐phenylundecanoyl acyl side chains with aromatic substitutions (14, 16–21) and Gal‐6′′‐phenylacetamide‐substituted α‐GalCer analogues bearing p‐nitro‐ (32), p‐tert‐butyl (34), or o‐, m‐, or p‐methyl groups (40–42) displayed higher IFN‐γ/IL‐4 secretion ratios than α‐GalCer in vitro. In mice, compound 16, with an 11‐(3,4‐difluorophenyl)undecanoyl acyl chain, induced significant proliferation of NK and DC cells, which should be beneficial in killing tumors and priming the immune response. These new glycolipids might prove useful as adjuvants or anticancer agents.
Methods in Molecular Biology 800: Chemical Genomics and Proteomics: Reviews and Protocols. Edited by Edward D. Zanders.
Authors: Chen Siyuan
Published: June 2012

Humana Press, Totowa 2012, XI+243 pp., hardcover $ 119.00.—ISBN 978‐1‐61779‐348‐6
Tailored Noble Metal Nanoparticles on γ‐Al2O3 for High Temperature CH4 Conversion to Syngas
Authors: Berger‐Karin Claudia , Sebek Michael , Pohl Marga‐Martina , Bentrup Ursula , Kondratenko Vita A. , Steinfeldt Norbert , Kondratenko Evgenii V.
Published: June 2012

The simple deposition of tailored Rh or Pt nanoparticles (NP) on γ‐Al2O3 results in active, selective, and stable catalysts for partial oxidation of methane (POM) to syngas. The NP were prepared by the ethylene glycol method in strong alkaline solution. This approach was found to be a promising way of providing active metallic NP for catalyzing the POM reaction. NP sizes determined by small angle X‐ray scattering (SAXS) in solution and by transmission electron microscopy (TEM) on alumina were very close. This result highlights the possibility of easy pre‐characterization of NP by the former method. Supported Rh NP are intrinsically more active in the POM reaction than Pt NP and also showed a superior performance compared with a conventionally prepared Rh catalyst, even if the latter had been pre‐reduced. Mechanistic investigations in the temporal analysis of products (TAP) reactor indicate that the higher selectivity of well‐defined Rh‐NP is determined by their lower activity for consecutive CO transformations.
Phase Behavior and Mesophase Structures of 1,3,5‐Benzene‐ and 1,3,5‐Cyclohexanetricarboxamides: Towards an Understanding of the Losing Order at the Transition into the Isotropic Phase
Authors: Timme Andreas , Kress Roman , Albuquerque Rodrigo Q. , Schmidt Hans‐Werner
Published: June 2012

One of the simplest and most‐versatile motifs in supramolecular chemistry is based on 1,3,5‐benzenetricarboxamides. Variation of the core structure and subtle changes in the structures of the lateral substituents govern the self‐assembly and determine the phase behavior. Herein, we provide a comprehensive comparison between the phase behavior and mesophase structure of a series of 1,3,5‐benzene‐ and 1,3,5‐cyclohexanetricarboxamides that contain linear and branched alkyl substituents. Depending on the substituent, different crystalline, plastic crystalline, and liquid crystalline phases were formed. The relatively rare columnar nematic (NC) phase was only observed in cyclohexane‐based trisamides that contained linear alkyl substituents. Of fundamental interest in liquid crystalline supramolecular systems is the transition from the mesomorphic state into the isotropic state and, in particular, the question of how the order decreases. Temperature‐dependent IR spectroscopy and XRD measurements revealed that columnar H‐bonded aggregates were still present in the isotropic phase. At the clearing transition, mainly the lateral order was lost, whilst shorter columnar aggregates still remained. A thorough understanding of the phase behavior and the mesophase structure is relevant for selecting processing conditions that use supramolecular structures in devices or as fibrillar nanomaterials.
Poly(2,5‐dimercapto‐1,3,4‐thiadiazole) as a Cathode for Rechargeable Lithium Batteries with Dramatically Improved Performance
Authors: Gao Jie , Lowe Michael A. , Conte Sean , Burkhardt Stephen E. , Abruña Héctor D.
Published: June 2012

Organosulfur compounds with multiple thiol groups are promising for high gravimetric energy density electrochemical energy storage. We have synthesized a poly(2,5‐dimercapto‐1,3,4‐thiadiazole) (PDMcT)/poly(3,4‐ethylenedioxythiophene) (PEDOT) composite cathode for lithium‐ion batteries with a new method and investigated its electrochemical behavior by charge/discharge cycles and cyclic voltammetry (CV) in an ether‐based electrolyte. Based on a comparison of the electrochemical performance with a carbonate‐based electrolyte, we found a much higher discharge capacity, but also a very attractive cycling performance of PDMcT by using a tetra(ethylene glycol) dimethyl ether (TEGDME)‐based electrolyte. The first discharge capacity of the as‐synthesized PDMcT/PEDOT composite approached 210 mAh g−1 in the TEGDME‐based electrolyte. CV results clearly show that the redox reactions of PDMcT are highly reversible in this TEGDME‐based electrolyte. The reversible capacity remained around 120 mAh g−1 after 20 charge/discharge cycles. With improved cycling performance and very low cost, PDMcT could become a very promising cathode material when combined with a TEGDME‐based electrolyte. The poor capacity in the carbonate‐based electrolyte is a consequence of the irreversible reaction of the DMcT monomer and dimer with the solvent, emphasizing the importance of electrolyte chemistry when studying molecular‐based battery materials.
Theoretical Insights into the Mechanism of Carbon Monoxide (CO) Release from CO‐Releasing Molecules
Authors: Vummaleti Sai Vikrama Chaitanya , Branduardi Davide , Masetti Matteo , De Vivo Marco , Motterlini Roberto , Cavalli Andrea
Published: June 2012

We used density functional theory to investigate the capacity for carbon monoxide (CO) release of five newly synthesized manganese‐containing CO‐releasing molecules (CO‐RMs), namely CORM‐368 (1), CORM‐401 (2), CORM‐371 (3), CORM‐409 (4), and CORM‐313 (5). The results correctly discriminated good CO releasers (1 and 2) from a compound unable to release CO (5). The predicted MnCO bond dissociation energies were well correlated (R2≈0.9) with myoglobin (Mb) assay experiments, which quantified the formation of MbCO, and thus the amount of CO released by the CO‐RMs. The nature of the MnCO bond was characterized by natural bond orbital (NBO) analysis. This allowed us to identify the key donor–acceptor interactions in the CO‐RMs, and to evaluate the MnCO bond stabilization energies. According to the NBO calculations, the charge transfer is the major source of MnCO bond stabilization for this series. On the basis of the nature of the experimental buffers, we then analyzed the nucleophilic attack of putative ligands (L′=HPO42−, H2PO4−, H2O, and Cl−) at the metal vacant site through the ligand‐exchange reaction energies. The analysis revealed that different L′‐exchange reactions were spontaneous in all the CO‐RMs. Finally, the calculated second dissociation energies could explain the stoichiometry obtained with the Mb assay experiments.
Second‐Generation Supramolecular Dendrimer with a Defined Structure due to Orthogonal Binding
Authors: Eckelmann Jens , Dethlefs Christiane , Brammer Stefan , Doğan Ahmet , Uphoff Andreas , Lüning Ulrich
Published: June 2012

A second‐generation supramolecular dendrimer has been prepared by orthogonal multiple hydrogen bonding. In the first (inner) recognition domain, the interaction of one bis‐isocyanuric acid (25) with two branching units (21) that carry complementary Hamilton receptors has been exploited. In the second (outer) generation, the two ADDA (A=hydrogen‐bond acceptor, D=donor) receptors of each branching unit (21) have bound complementary DAAD units (4). The problem of limited solubility of the building blocks has been overcome by the introduction of branched ethylhexyl residues and by the use of flexible alkylene or oligo(ethylene glycol) linking chains. The orthogonal binding of the two hydrogen‐bonding pairs was elucidated by chemical induced shift NMR titrations, which proved that the two pairs, isocyanuric acid with the Hamilton receptor and ADDA with DAAD, bind preferentially. The formation of the supramolecular self‐assembled 1:2:4 dendrimer with a molecular weight of 5065 g mol−1 was investigated by diffusion NMR spectroscopy.
Synthesis, Coordination Behavior, and Reduction Chemistry of Cymantrenyl‐1,3‐bis(2,3,4,5‐tetraphenyl)borole
Authors: Braunschweig Holger , Damme Alexander , Gamon Daniela , Kelch Hauke , Krummenacher Ivo , Kupfer Thomas , Radacki Krzysztof
Published: June 2012

We describe the synthesis of base‐free bisborole [Cym†(BC4Ph4)2]—Cym†=(OC)3Mn(η5‐C5H3)—and its transformation into two fully characterized Lewis acid–base adducts with pyridine bases of the type 4‐RNC5H4 (R=tBu, NMe2). The results of electrochemical, as well as NMR and UV/Vis spectroscopic studies on [Cym†(BC4Ph4)2] and the related monoborole derivative [Cym(BC4Ph4)]—Cym=(OC)3Mn(η5‐C5H4)—provided conclusive evidence for 1) the enhanced Lewis acidity of the two boron centers that result from conjugation of two borole fragments, and 2) the fact that MnB bonding interactions between the Lewis acidic borole moieties and the Mn center are considerably less pronounced for bisborole [Cym†(BC4Ph4)2]. In addition, the reduction chemistry of [Cym†(BC4Ph4)2] has been studied in detail, both electrochemically and chemically. Accordingly, chemical reduction of [Cym†(BC4Ph4)2] with magnesium anthracene afforded the corresponding tetraanion, which features a rare MgOC bonding mode in the solid state.
A Mechanistic Study of the Utilization of arachno‐Diruthenaborane [(Cp*RuCO)2B2H6] as an Active Alkyne‐Cyclotrimerization Catalyst
Authors: Geetharani K. , Tussupbayev Samat , Borowka Julia , Holthausen Max C. , Ghosh Sundargopal
Published: June 2012

The reaction of nido‐[1,2‐(Cp*RuH)2B3H7] (1 a, Cp*=η5‐C5Me5) with [Mo(CO)3(CH3CN)3] under mild conditions yields the new metallaborane arachno‐[(Cp*RuCO)2B2H6] (2). Compound 2 catalyzes the cyclotrimerization of a variety of internal‐ and terminal alkynes to yield mixtures of 1,3,5‐ and 1,2,4‐substituted benzenes. The reactivities of nido‐1 a and arachno‐2 with alkynes demonstrates that a change in geometry from nido to arachno drives a change in the reaction from alkyne‐insertion to catalytic cyclotrimerization, respectively. Density functional calculations have been used to evaluate the reaction pathways of the cyclotrimerization of alkynes catalyzed by compound 2. The reaction involves the formation of a ruthenacyclic intermediate and the subsequent alkyne‐insertion step is initiated by a [2+2] cycloaddition between this intermediate and an alkyne. The experimental and quantum‐chemical results also show that the stability of the metallacyclic intermediate is strongly dependent on the nature of the substituents that are present on the alkyne.
Walking Metals in d8⋅⋅⋅d8 Hetero‐bimetallic Complexes: An Original Dynamic Phenomenon
Authors: Nebra Noel , Ladeira Sonia , Maron Laurent , Martin‐Vaca Blanca , Bourissou Didier
Published: June 2012

In the course of our investigations on polymetallic complexes derived from 1,3‐bis(thiophosphinoyl)indene (Ind(Ph2PS)2), we observed original fluxional behavior and report herein a joint experimental/computational study of this dynamic process. Starting from the indenylidene chloropalladate species [Pd{Ind(Ph2PS)2}Cl]− (1), the new PdII⋅⋅⋅RhI hetero‐bimetallic pincer complex [PdCl{Ind(Ph2PS)2}Rh(nbd)] (2; nbd=2,5‐norbornadiene) was prepared. X‐ray crystallography and DFT calculations substantiate the presence of a d8⋅⋅⋅d8 interaction. According to multinuclear variable‐temperature NMR spectroscopic experiments, the pendant {Rh(nbd)} fragment of 2 readily shifts in solution at room temperature between the two edges of the SCS tridentate ligand. To assess the role of the pincer‐based polymetallic structure on this fluxional behavior, the related monometallic Rh complex [Rh{IndH(Ph2PS)2}(nbd)] (3) was prepared. No evidence for a metal shift was observed in that case, even at high temperature, thus indicating that inplane pincer coordination to the Pd center plays a crucial role. The previously described PdII⋅⋅⋅IrI bimetallic complex 4 exhibited fluxional behavior in solution, but with a significantly higher activation barrier than 2. This finding demonstrates the generality of this metal‐shift process and the strong influence of the involved metal centers on the associated activation barrier. DFT calculations were performed to shed light onto the mechanism of such metal‐shift processes and to identify the factors that influence the associated activation barriers. Significantly different pathways were found for bimetallic complexes 2 and 4 on one hand and the monometallic complex 3 on the other hand. The corresponding activation barriers predicted computationally are in very good agreement with the experimental observations.
Parasite‐Based Screening and Proteome Profiling Reveal Orlistat, an FDA‐Approved Drug, as a Potential Anti Trypanosoma brucei Agent[]
Authors: Yang Peng‐Yu , Wang Min , Liu Kai , Ngai Mun Hong , Sheriff Omar , Lear Martin J. , Sze Siu Kwan , He Cynthia Y. , Yao Shao Q.
Published: June 2012

Trypanosoma brucei is a parasite that causes African sleeping sickness in humans and nagana in livestock and is transmitted by the tsetse fly. There is an urgent need for the development of new drugs against African trypanosomiasis due to the lack of vaccines and effective drugs. Orlistat (also called tetrahydrolipstatin or THL) is an FDA‐approved antiobesity drug targeting primarily the pancreatic and gastric lipases within the gastrointestinal tract. It shows potential activities against tumors, mycobacteria, and parasites. Herein, we report the synthesis and evaluation of an expanded set of orlistat‐like compounds, some of which showed highly potent trypanocidal activities in both the bloodstream form (BSF) and the procyclic form (PCF) of T. brucei. Subsequent in situ parasite‐based proteome profiling was carried out to elucidate potential cellular targets of the drug in both forms. Some newly identified targets were further validated by the labeling of recombinantly expressed enzymes in Escherichia coli lysates. Bioimaging experiments with a selected compound were carried out to study the cellular uptake of the drug in T. brucei. Results indicated that orlistat is much more efficiently taken up by the BSF than the PCF of T. brucei and has clear effects on the morphology of mitochondria, glycosomes, and the endoplasmic reticulum in both BSF and PCF cells. These results support specific effects of orlistat on these organelles and correlate well with our in situ proteome profiling. Given the economic challenges of de novo drug development for neglected diseases, we hope that our findings will stimulate further research towards the conversion of orlistat‐like compounds into new trypanocidal drugs.
Ion‐Exchange‐Assisted Synthesis of Pt‐VC Nanoparticles Loaded on Graphitized Carbon: A High‐Performance Nanocomposite Electrocatalyst for Oxygen‐Reduction Reactions
Authors: He Guoqiang , Yan Zaoxue , Cai Mei , Shen Pei Kang , Gao Min‐Rui , Yao Hong‐Bin , Yu Shu‐Hong
Published: June 2012

Carbide‐based electrocatalysts are superior to traditional carbon‐based electrocatalysts, such as the commercial Pt/C electrocatalysts, in terms of their mass activity and stability. Herein, we report a general approach for the preparation of a nanocomposite electrocatalyst of platinum and vanadium carbide nanoparticles that are loaded onto graphitized carbon. The nanocomposite, which was prepared in a localized and controlled fashion by using an ion‐exchange process, was an effective electrocatalyst for the oxygen‐reduction reaction (ORR). Both the stability and the durability of the Pt‐VC/GC nanocomposite catalyst could be enhanced compared with the state‐of‐the‐art Pt/C. This approach can be extended to the synthesis of other metal‐carbide‐based nanocatalysts. Moreover, this straightforward synthesis of high‐performance composite nanocatalysts can be scaled up to meet the requirements for mass production.
Experimental Support for the Role of Dispersion Forces in Aromatic Interactions
Authors: Lima Carlos F. R. A. C. , Rocha Marisa A. A. , Gomes Lígia R. , Low John N. , Silva Artur M. S. , Santos Luís M. N. B. F.
Published: June 2012

Herein a core scaffold of 1‐phenylnaphthalenes and 1,8‐diphenylnaphthalenes with different substituents on the phenyl rings was used to study substituent effects on parallel‐displaced aromatic π⋅⋅⋅π interactions. The energetics of the interaction was evaluated in gas phase based on the standard molar enthalpies of formation, at T=298.15 K, for the compounds studied; these values were derived from the combination of the results obtained by combustion calorimetry and Knudsen/Quartz crystal effusion. A homodesmotic gas‐phase reaction scheme was used to quantify and compare the intramolecular interaction enthalpies in various substituted 1,8‐diphenylnaphthalenes. The application of this methodology allowed a direct evaluation of aromatic interactions, and showed that substituent effects on the interaction enthalpy cannot be rationalized solely on classical electrostatic grounds, because no correlation with the σmeta or σpara Hammett constants was observed. Moreover, the results obtained indicate that aromatic π⋅⋅⋅π interactions are significantly enhanced by substitution, in a way that correlates with the ability of the interacting aryl rings to establish dispersive interactions. A combined experimental and computational approach for calculation of the true aromatic π⋅⋅⋅π interaction energies in these systems, free of secondary effects, was employed, and corroborates the rationale derived from the experimental results. These findings clearly emphasize the role of dispersion and dilute the importance of electrostatic forces on this type of interactions.
ChemInform Abstract: Crystal Structure of the Fe6‐xGayGe5‐y (x ≈ 0.5, y = 1.3) Ternary Compound.
Authors: Lyutyy P. Ya. , Svitlyk V. O. , Fedorchuk A. O.
Published: June 2012

Single crystals of the title compound are prepared by arc‐melting of the elements and characterized by SEM and single crystal XRD.
ChemInform Abstract: Intermediate‐Valent Cerium in Ce2Ru4Mg17 and a Group‐Subgroup Scheme for La9Ru4In5 and Ce9Ru4Ga5.
Authors: Linsinger Stefan , Hoffmann Rolf‐Dieter , Eul Matthias , Poettgen Rainer
Published: June 2012

Ce2Ru4Mg17 is synthesized by high‐frequency melting of the elements in a Ta ampule and characterized by powder and single crystal XRD, and magnetic measurements.
ChemInform Abstract: Low‐Temperature Diffusion of Oxygen Through Ordered Carbon Vacancies in Zr2Cx: The Formation of Ordered Zr2CxOy.
Authors: Tian Yongjun , et al. et al.
Published: June 2012

Low‐temperature oxygen diffusion in carbon vacancy ordered ZrC0.6 and the induced formation of oxygen ordered ZrC0.6O0.4 is characterized by XRD, SAED, and TEM.
ChemInform Abstract: Photocatalytic and Photoelectric Properties of Cubic Ag3PO4 Sub‐microcrystals with Sharp Corners and Edges.
Authors: Bi Yingpu , Hu Hongyan , Ouyang Shuxin , Lu Gongxuan , Cao Junyu , Ye Jinhua
Published: June 2012

The title sub‐microcubes are prepared in high yields by reaction of AgNO3 dissolved in aqueous NH3 with Na2HPO4 at room temperature.
ChemInform Abstract: Synthesis and Visible Light Photocatalytic Activity of β‐AgVO3 Nanowires.
Authors: Xu Jing , Hu Chenguo , Xi Yi , Wan Buyong , Zhang Cuiling , Zhang Yan
Published: June 2012

The title nanowires with diameters of about 200—700 nm and lengths up to 300 μm are hydrothermally synthesized from AgNO3 powder, vanadium foil, and H2O (autoclave, 200 °C, 20 h).
ChemInform Abstract: New Layered Compounds with Honeycomb Ordering: Li3Ni2BiO6, Li3NiM′BiO6 (M′: Mg, Cu, Zn), and the Delafossite Ag3Ni2BiO6.
Authors: Berthelot Romain , Schmidt Whitney , Muir Sean , Eilertsen James , Etienne Laetitia , Sleight A. W. , Subramanian M. A.
Published: June 2012

The lithium nickel bismuthates of title are prepared by solid state reactions using Li2CO3, NiO, Bi2O3, and MgO, CuO, or ZnO as starting materials (Au crucible, air or O2 flow, 550—900 °C, 12—48 h).
ChemInform Abstract: Mo‐Substituted Keggin Tungstosilicate Microtubes: Preparation and Characterization.
Authors: Shen Yan , Peng Jun , Zhang Huanqiu , Yu Xia , Bond Alan M.
Published: June 2012

K3.8Na0.2SiMoVIW11O40 ·4H2O microtubes are prepared by addition of HCl to an aqueous solution of α‐K8[SiW11O39] and Na2MoO4 (80 °C, 15 min, yield given in g).
ChemInform Abstract: A New Partially Deprotonated Mixed‐Valence Manganese(II,III) Hydroxide—Arsenate with Electronic Conductivity: Magnetic Properties of High‐ and Room‐Temperature Sarkinite.
Authors: de Pedro Imanol , Rojo Jose M. , Rius Jordi , Vallcorba Oriol , Ruiz de Larramendi Idoia , Rodriguez Fernandez Jesus , Lezama Luis , Rojo Teofilo
Published: June 2012

The new three‐dimensional compound Mn8(O4Hx)(AsO4)4 (x ≈ 3) is prepared by heating Mn2(OH)AsO4 in air at 500 °C.
ChemInform Abstract: β‐Technetium Trichloride: Formation, Structure, and First‐Principles Calculations.
Authors: Poineau Frederic , Johnstone Erik V. , Weck Philippe F. , Forster Paul M. , Kim Eunja , Czerwinski Kennth R. , Sattelberger P.
Published: June 2012

The new polymorph β‐TcCl3 is prepared by reaction of Tc metal and Cl2 gas (450 °C, 24 h, yield given in g) and characterized by single crystal XRD and DFT calculations.
ChemInform Abstract: A Polyoxometalate—Cyanometalate Multilayered Coordination Network.
Authors: Compain Jean‐Daniel , Nakabayashi Koji , Ohkoshi Shin‐ichi
Published: June 2012

The new compound [ε‐PMo12O37(OH)3{La (H2O)5(Fe (CN)6)0.25}4] ·12H2O (I) is synthesized from a solution of [ε‐PMo12O36(OH)4{La (H2O)4}4]Br5 and Na4[Fe(CN)6] in H2O (20 °C, 5 min, 84% yield).
ChemInform Abstract: Electrochemical Oxidation of Catechols in the Presence of Ketene N,O‐Acetals: Indole Formation versus α‐Arylation.
Authors: Bai Yue‐Xia , Ping Da‐Wei , Little R. Daniel , Tian Hong‐Yu , Hu Li‐Ming , Zeng Cheng‐Chu
Published: June 2012

The procedure works with cyclic voltammetry and constant current electrolysis methods.
ChemInform Abstract: Merging Organocatalysis with Transition Metal Catalysis: Highly Stereoselective α‐Alkylation of Aldehydes.
Authors: Xiao Jian
Published: June 2012

CuCl, InBr3, and InF3 can be used in combination with the proline compound.
ChemInform Abstract: Nickel‐Catalyzed Enantioselective Cross‐Couplings of Racemic Secondary Electrophiles that Bear an Oxygen Leaving Group.
Authors: Oelke Alexander J. , Sun Jianwei , Fu Gregory C.
Published: June 2012

A variety of silyl‐substituted propargylic carbonates are coupled with arylzinc iodides in the presence of a nickel/chiral bis(oxazolinyl)pyridine catalyst to give the arylated alkynes with up to 93% enantioselectivity.
ChemInform Abstract: Regioselective Solvent‐Dependent Benzannulation of Conjugated Enynes.
Authors: Puenner Florian , Hilt Gerhard
Published: June 2012

The cobalt‐catalyzed title reaction leads to symmetrical benzannulation products in dichloromethane.
ChemInform Abstract: Regioselective Cycloaddition of 3‐Azetidinones and 3‐Oxetanones with Alkynes Through Nickel‐Catalyzed Carbon—Carbon Bond Activation.
Authors: Ho Kelvin Y. T. , Aissa Christophe
Published: June 2012

The title reaction affords pyridinones and pyranones, correspondingly, with good to modest regioselectivity in the case of unsymmetrically internal alkynes.
ChemInform Abstract: Merging Domino and Redox Chemistry: Stereoselective Access to Di‐ and Trisubstituted β,γ‐Unsaturated Acids and Esters.
Authors: Tejedor David , Mendez‐Abt Gabriela , Cotos Leandro , Garcia‐Tellado Fernando
Published: June 2012

Depending on the solvent, MeOH or water, the microwave‐assisted rearrangement of propargyl vinyl ethers affords alkenes bearing a malonate unit, or an ester/free acid group at the allylic position.
ChemInform Abstract: Green Bromine: In situ Generated Catalyst for the Selective Oxidation of Alcohols Using H2O2 as a Benign Oxidant.
Authors: Joshi Girdhar , Patil Rajendra D. , Adimurthy Subbarayappa
Published: June 2012

Under acid activation, a 5:1 NaBr/NaBrO3 mixture in situ generates Br2/BrOH species which catalyze the oxidation of benzylic/secondary alcohols by H2O2 to the corresponding aldehydes/ketones.
ChemInform Abstract: Transformation of Amines to Oximes Using Heterogeneous Nanocrystalline Titanium(IV) Oxide as a Green Catalyst.
Authors: Kidwai Mazaahir , Bhardwaj Saurav
Published: June 2012

Optimum reaction conditions (solvent, catalyst) are examined for the oxidation of amines to the corresponding oximes using H2O2.
ChemInform Abstract: Hydrated Nickel(II) Halides Mediated Ring Opening Reaction with N‐Tosylaziridines.
Authors: Zhang Wan Xuan , Hu Wei Gang , Su Li , Liu Li Qin
Published: June 2012

Aziridines as important synthetic intermediates are subjected to a regioselective ring opening.
ChemInform Abstract: Selective Alkylation of (Hetero)Aromatic Amines with Alcohols Catalyzed by a Ruthenium Pincer Complex.
Authors: Agrawal Santosh , Lenormand Maud , Martin‐Matute Belen
Published: June 2012

The lack of reactivity concerning aliphatic amines prevents polyalkylation, i.e.
ChemInform Abstract: Direct Regiospecific and Highly Enantioselective Intermolecular α‐Allylic Alkylation of Aldehydes by a Combination of Transition‐Metal and Chiral Amine Catalysts.
Authors: Afewerki Samson , Ibrahem Ismail , Rydfjord Jonas , Breistein Palle , Cordova Armando
Published: June 2012

The present allylic alkylation of various linear aldehydes (II), catalyzed by an achiral palladium complex and a chiral amine as co‐catalyst, gives the corresponding alcohols after in situ reduction with NaBH4.
ChemInform Abstract: Ti/Ni‐Based Multimetallic System for the Efficient Allylation of Carbonyl Compounds.
Authors: Martinez‐Peragon Angela , Millan Alba , Campana Araceli G. , Rodriguez‐Marquez Irene , Resa Sandra , Miguel Delia , Alvarez de Cienfuegos Luis , Cuerva Juan M.
Published: June 2012

A mild system for the allylation of carbonyl compounds includes Ni/Ti or Pd/Ti and allyl carbonates as pronucleophiles.
ChemInform Abstract: Stereoselective C‐Glycosylation Reactions with Arylzinc Reagents.
Authors: Lemaire Sebastien , et al. et al.
Published: June 2012

The procedure affords the β‐anomers exclusively.
ChemInform Abstract: Cationic Gold‐Catalyzed Regioselective Hydration of 1‐Arylalkynes Through Carbonyl Group Participation.
Authors: Jeong Jiseon , Ray Devalina , Oh Chang Ho
Published: June 2012

A mild method avoiding the use of toxic strong acids and other additives is developed.
ChemInform Abstract: 1,4‐Induction in Aldol Reactions of (Tertiary α′‐Alkoxy)methyl Ketones: Synthesis of the C8—C11 Stereotriad of ent‐Fostriecin.
Authors: Cowper Nicholas , Azzi Soula , Dupont‐Gaudet Kristina , Burch Jason D.
Published: June 2012

A general diastereoselective aldol condensation using a tertiary α′‐alkoxy group as the sterochemical control element is developed.
ChemInform Abstract: Synthesis of Functionalized Dialkyl Ketones from Carboxylic Acid Derivatives and Alkyl Halides.
Authors: Wotal Alexander C. , Weix Daniel J.
Published: June 2012

The procedure can be applied to a broad spectrum of substrates and includes even formation of hindered ketones.
ChemInform Abstract: Dehydrative Fragmentation of 5‐Hydroxyalkyl‐1H‐tetrazoles: A Mild Route to Alkylidenecarbenes.
Authors: Wardtrop Duncan J. , Komenda John P.
Published: June 2012

The tetrazoles are prepared via an optimized literature procedure starting from aldehydes, ketones or ynones.
ChemInform Abstract: α,β‐Unsaturated Imines via Ru‐Catalyzed Coupling of Allylic Alcohols and Amines.
Authors: Rigoli Jared W. , Moyer Sara A. , Pearce Simon D. , Schomaker Jennifer M.
Published: June 2012

A mild and atom‐economical synthesis of the title compounds by using a commercially available catalyst without the use of suprastoichiometric amounts of oxidants or dehydrating reagents is presented.
ChemInform Abstract: Rhodium(I)/Diene‐Catalyzed Addition Reactions of Arylborons with Ketones.
Authors: Liao Yuan‐Xi , Xing Chun‐Hui , Hu Qiao‐Sheng
Published: June 2012

Various tertiary alcohols can be prepared from arylboroxines and unactivated ketones.
ChemInform Abstract: A Convenient and Practical Synthesis of Anisoles and Deuterated Anisoles by Palladium‐Catalyzed Coupling Reactions of Aryl Bromides and Chlorides.
Authors: Gowrisankar Saravanan , Neumann Helfried , Beller Matthias
Published: June 2012

(Hetero)aryl halides undergo selective C—O cross‐coupling reactions with methanol in the presence of a catalyst system consisting of Pd(OAc)2 and a bispyrazolylphosphine ligand giving the corresponding ethers (III) in good yields.
ChemInform Abstract: An In‐Water, On‐Water Domino Process for Synthesis.
Authors: Norcott Philip , Spielman Calan , McErlean Christopher S. P.
Published: June 2012

The reaction of anilines (I) with 2‐methylhydroquinone (II) in aqueous hydrogen peroxide gives rise to a mixture of regioisomeric anilinoquinones (III) and (IV).
ChemInform Abstract: Asymmetric Synthesis of γ‐Nitroesters by an Organocatalytic One‐Pot Strategy.
Authors: Jensen Kim L. , Poulsen Pernille H. , Donslund Bjarke S. , Morana Fabio , Joergensen Karl Anker
Published: June 2012

In the reaction of some aldehydes (V), formation of acetal by‐products is inhibited by increasing the amount of NBS.
ChemInform Abstract: FeCl3·6H2O‐Catalyzed Acceleration of the Acylation of Sodium Azide with N‐Acylbenzotriazoles.
Authors: Zhong Zhiyun , Hu Jieling , Wang Xiaoxia , Liu Junhua , Zhang Longfeng
Published: June 2012

Complete conversion of starting compounds (I) and easy removal of the catalyst and the by‐product makes the protocol suitable for large‐scale preparation.
ChemInform Abstract: Zinc Chloride Catalyzed Three‐Component Ugi Reaction: Synthesis of N‐Cyclohexyl‐2‐(2‐hydroxyphenylamino)acetamide Derivatives.
Authors: Shaabani Ahmad , Keshipour Sajjad , Shaabani Shabnam , Mahyari Mojtaba
Published: June 2012

Either aldehydes or analogous substrates (V) and (VII) can be used for the preparation of the title compounds as a class of pharmaceutical active substances.
ChemInform Abstract: Cyanation of Aryl Bromides with K4[Fe(CN)6] Catalyzed by Dichloro[bis{1‐(dicyclohexylphosphanyl)piperidine}]palladium, a Molecular Source of Nanoparticles, and the Reactions Involved in the Catalyst‐Deactivation Processes.
Authors: Gerber Roman , Oberholzer Miriam , Frech Christian M.
Published: June 2012

PCP is as a highly active catalyst for cyanation reactions of various (hetero)aryl bromides.
ChemInform Abstract: Pd‐Catalyzed Decarboxylative Cross‐Couplings of Potassium Malonate Monoesters with Aryl Halides.
Authors: Feng Yi‐Si , Wu Wei , Xu Zhong‐Qiu , Li Yan , Li Ming , Xu Hua‐Jian
Published: June 2012

The use of aryl chlorides instead of aryl bromides gives the products in lower yields.
ChemInform Abstract: Aryl Methyl Sulfides as Substrates for Rhodium‐Catalyzed Alkyne Carbothiolation: Arene Functionalization with Activating Group Recycling.
Authors: Hooper Joel F. , Chaplin Adrian B. , Gonzalez‐Rodriguez Carlos , Thompson Amber L. , Weller Andrew S. , Willis Michael C.
Published: June 2012

The optimized Rh(I)‐catalyzed reaction of aryl methyl sulfides such as (I) with terminal alkynes affords arylvinyl methyl sulfides.
ChemInform Abstract: Palladium‐Catalyzed Site‐Selective Arylation of Symmetric Dichlorobenzaldehyde to Non‐symmetric Diaryl Benzaldehyde via Suzuki Coupling.
Authors: Dey Raju , Ranu Brindaban C.
Published: June 2012

A convenient strategy for the synthesis of unsymmetrical 2,6‐diarylbenzaldehydes from substrate (I) is developed.
ChemInform Abstract: Design of N‐Cinnamyl Sulfinamides as New Sulfur‐Containing Olefin Ligands for Asymmetric Catalysis: Achieving Structural Simplicity with a Categorical Linear Framework.
Authors: Jin Shen‐Shuang , Wang Hui , Zhu Ting‐Shun , Xu Ming‐Hua
Published: June 2012

A novel, unique, chiral, and structurally simple sulfonamide‐olefin ligand is applied to the presented highly enantioselective 1,4‐addition reactions.
ChemInform Abstract: First Synthesis and Anticancer Activity of Novel Naphthoquinone Amides.
Authors: Pradidphol Narathip , Kongkathip Ngampong , Sittikul Pichamon , Boonyalai Nanlawat , Kongkathip Boonsong
Published: June 2012

Starting from 1‐hydroxy‐2‐naphthoic acid, a series of novel naphthoquinone aromatic amides is synthesized by a new route using Fremy′s salt oxidation and tBu‐OOH/TritanB hydroxylation as the key steps.
ChemInform Abstract: Rhodium‐Catalyzed C—H Bond Activation/[4 + 2] Annulation/Aromatization Cascade to Produce Phenol, Naphthol, Phenanthrenol, and Triphenylenol Derivatives.
Authors: Hojo Daiki , Tanaka Ken
Published: June 2012

Readily available conjugated alkynyl aldehydes and alkynes are suitable substrates for a successful title process.
ChemInform Abstract: Regioselective Arylation and Alkynylation of 2,3‐Dibromo‐1H‐inden‐1‐one by Suzuki—Miyaura and Sonogashira Cross‐Coupling Reactions.
Authors: Khera Rasheed Ahmad , Hussain Munawar , Nguyen Thai Hung , Eleya Nadi , Feist Holger , Villinger Alexander , Langer Peter
Published: June 2012

The Suzuki—Miyaura cross‐coupling of 2,3‐dibromo‐indenone (I) with 1 equiv.
ChemInform Abstract: Synthesis of 1‐Substituted 2‐Azaspiro[4.5]deca‐6,9‐dien‐8‐ones and 2‐Azaspiro[4.5]deca‐1,6,9‐trien‐8‐ones by Condensation of 2,6‐Dimethylphenol with Isobutyraldehydes and Nitriles.
Authors: Rozhkova Yu. S. , Khmelevskaya K. A. , Shklyaev Yu. V. , Ezhikova M. A. , Kodess M. I.
Published: June 2012

Three‐component condensation of dimethylphenol (I) with isobutyraldehyde (II) and nitriles (III) and (V) in concentrated sulfuric acid gives rise to formation of spiro compounds (IV) and (VI), respectively.
ChemInform Abstract: Synthesis and Biological Evaluation of Novel Amprenavir‐Based P1‐Substituted Bi‐Aryl Derivatives as Ultra‐Potent HIV‐1 Protease Inhibitors.
Authors: Yan Jianwei , Huang Ning , Li Shukun , Yang Liu‐Meng , Xing Weiqiang , Zheng Yong‐Tang , Hu Youhong
Published: June 2012

Some of the title compounds (I) show strong antiviral activities.
ChemInform Abstract: Novel Intramolecular Photocyclization of α‐Arylthiophene Derivatives.
Authors: Arai Noriyoshi , Tanaka Koichiro , Ohkuma Takeshi
Published: June 2012

The reaction is only successful with an aryl substituent at the 2‐position of the thiophene and the unique tricyclic skeletons are obtained as single diastereomers.
ChemInform Abstract: Stereoselective Synthesis of Two New Trihydroxylated Pyrrolidines Using a Meyer—Schuster Rearrangement
Authors: Swamy Nalivela Kumara , Pyne Stephen G.
Published: June 2012

(III)→(IV) as the key step
ChemInform Abstract: High‐Pressure Accelerated Asymmetric Organocatalytic Friedel—Crafts Alkylation of Indoles with Enones: Application to Quaternary Stereogenic Centers Construction.
Authors: Lyzwa Dawid , Dudzinski Krzysztof , Kwiatkowski Piotr
Published: June 2012

Generally, good e.e values are observed for the products.
ChemInform Abstract: Direct Oxidative C—P Bond Formation of Indoles with Dialkyl Phosphites.
Authors: Wang Haolong , Li Xincheng , Wu Fan , Wan Boshun
Published: June 2012

Complete regioselectivity is observed for 1,2‐unsubstituted substrates such as (I), whereas low amounts of 3‐phosphorylated products are also identified in the case of N‐methylated analogue (IV).
ChemInform Abstract: Synthesis, Structures, and Photochromic Properties of 3‐[(E)‐Alk‐1‐enyl] ‐4‐(1‐alkyl‐5‐methoxy‐2‐methyl‐1H‐indol‐3‐yl)furan‐2,5‐diones.
Authors: Popova L. L. , et al. et al.
Published: June 2012

New photochromic hetarylethenes (IV) are synthesized (5 examples) that are characterized by a high content of colored forms in the photostationary state compared to the unsubstituted analogues.
ChemInform Abstract: Kaolin/KOH Is an Efficient Heterogeneous Catalyst for the Synthesis of 3‐Hydroxy‐3‐indolyl Oxindoles.
Authors: Srihari G. , Murthy M. Marthanda
Published: June 2012

Kaolin preloaded with KOH is shown to be an efficient catalyst for the synthesis of the title compounds (III) from indoles (I) and isatins (II).
ChemInform Abstract: Facile Synthesis of β‐Lactam‐Grafted Spirooxindolopyrrolidine Through Regioselective 1,3‐Dipolar Cycloaddition Reaction.
Authors: Arumugam Natarajan , Raghunathan Raghavachary
Published: June 2012

In a one‐pot cycloaddition reaction, the azomethine ylide generated from β‐lactam (I) and sarcosine (II) reacts with (III) to afford spiropyrrolidine derivatives of type (IV).
ChemInform Abstract: Synthesis of Ionic Liquids Containing the Hydroxyl Functionality for Extracting Nonylphenol and Octylphenol in Water.
Authors: Fu Xin‐Mei , Dai Shu‐Gui
Published: June 2012

New ionic liquids containing the hydroxyl functionality (I) and (II) show much better extraction efficiencies for nonyl‐ and octylphenol than the common ionic liquids, such as [bmim]PF6.
ChemInform Abstract: Highly Stereoselective Catalytic Conjugate Addition of Acyl Anion Equivalent to Nitroolefins.
Authors: Uraguchi Daisuke , Ueki Yusuke , Ooi Takashi
Published: June 2012

Chiral tetraaminophosphonium aryloxide‐arylhydroxide CTAP is a highly efficient catalyst for the diastereo‐ and enantioselective addition of azlactone (I) to a range of nitroolefins.
ChemInform Abstract: Synthesis of Isoxazole Triflones.
Authors: Kawai Hiroyuki , Sugita Yutaka , Tokunaga Etsuko , Shibata Norio
Published: June 2012

The first practical synthesis of trifluoromethylsulfonyl‐substituted isoxazoles (III), (V) and (VII) is presented, involving base‐mediated cyclization of α‐triflyl ketones (I) and (VI) with aryl imidoyl chlorides (II) and (IV).
ChemInform Abstract: Facile Method for the Conversion of Semicarbazones/Thiosemicarbazones into Azines (under Microwave Irradiation) and Oxadiazoles (by Grinding).
Authors: Chattopadhyay Gautam , Ray Partha Sinha
Published: June 2012

Semicarbazones (I) adsorbed on silica give azines (II) on microwave irradiation.
ChemInform Abstract: Novel Imidazo[2,1‐b][1,3,4]thiadiazole Carrying Rhodanine‐3‐acetic Acid as Potential Antitubercular Agents.
Authors: Alegaon Shankar G. , Alagawadi Kallanagouda R. , Sonkusare Pranali V. , Chaudhary Sagar M. , Dadwe Dilip H. , Shah Amol S.
Published: June 2012

A simple, highly efficient, cost effective, and environmentally benign synthesis of the title compounds (IX) (7 examples) and related analogues (XI), (XIII) is developed using microwave technique.
ChemInform Abstract: InCl3 Catalyzed Domino Route to 2H‐Chromene‐2‐ones via [4 + 2] Annulation of 2‐Hydroxyarylaldehydes with α‐Oxoketene Dithioacetal under Solvent‐Free Conditions.
Authors: Verma Rajiv Kumar , Verma Girijesh Kumar , Shukla Gaurav , Singh Maya Shankar
Published: June 2012

A wide variety of coumarin derivatives is prepared (43 examples), including ferrocenylcarbonyl‐substituted structures.
ChemInform Abstract: Conventional and Microwave‐Assisted Syntheses and Solid‐State Structure of New Coumarins and Angelicins.
Authors: Hejchman Elzbieta , Trykowska Konc Joanna , Maciejewska Dorota , Kruszewska Hanna
Published: June 2012

New coumarin (IIIa) and new angelicin (IVa) show promising anticancer activities against selected leukemia, non‐small‐cell lung and renal cancer lines.
ChemInform Abstract: A Facile Route to Flavone and Neoflavone Backbones via a Regioselective Palladium Catalyzed Oxidative Heck Reaction.
Authors: Khoobi Mehdi , Alipour Masoumeh , Zarei Samaneh , Jafarpour Farnaz , Shafiee Abbas
Published: June 2012

A regioselective base‐free Pd‐catalyzed arylation of chromenones (I) and (IV) affords biologically interesting flavone or neoflavone derivatives.
ChemInform Abstract: Poly(4‐vinylpyridinium) Hydrogensulfate Catalyzed Synthesis of 12‐Aryl‐12H‐indeno[1,2‐b]naphtho[3,2‐e]pyran‐5,11,13‐triones.
Authors: Khaligh Nader Ghaffari
Published: June 2012

A novel method for the synthesis of polycyclic triones of type (IV) includes a three‐component condensation in the presence of a recycable heterogeneous catalyst.
ChemInform Abstract: Microwave‐Assisted Synthesis of Hydropyridines and Study of the DPPH‐Scavenging Activity.
Authors: Montes‐Avila Julio , Delgado‐Vargas Francisco , Diaz‐Camacho Sylvia P. , Rivero Ignacio A.
Published: June 2012

A variety of monocyclic or fused dihydropyridine derivatives is synthesized by use of microwave‐assisted Hantzsch protocol under solvent‐free conditions.
ChemInform Abstract: Diastereoselective Addition to N‐Acyliminium Ions with Aryl‐ and Alkenyl Boronic Acids via a Petasis‐Type Reaction.
Authors: Mizuta Satoshi , Onomura Osamu
Published: June 2012

2‐Aryl‐3‐hydroxypiperidines are obtained as single cis‐diastereomers by addition of aryl‐ or alkenylboronates to N‐protected piperidinium ions derived from the corresponding 2‐methoxy‐3‐hydroxypiperidines.
ChemInform Abstract: Synthesis of Aryl(di)azinyl Ketones Through Copper‐ and Iron‐Catalyzed Oxidation of the Methylene Group of Aryl(di)azinylmethanes.
Authors: De Houwer Johan , Tehrani Kourosch Abbaspour , Maes Bert U. W.
Published: June 2012

The simple protocol includes Cu(II)‐ or Fe(II)‐catalysis with oxygen as the terminal oxidant.
ChemInform Abstract: Synthesis of N‐Substituted Carbonylamino‐1,2,3,6‐tetrahydropyridines as Potential Antiinflammatory Agents.
Authors: Ghaffari Mohammad A. , Ardley Tiffany W. , Gangapuram Madhavi , Redda Kinfe K.
Published: June 2012

A series of novel tetrahydropyridinesis prepared following 2 slightly different synthetic strategies with pyridinium ylides (III) and (VII) as key intermediates.
ChemInform Abstract: Palladium‐Catalyzed Decarboxylative Coupling of Quinolinone‐3‐carboxylic Acids and Related Heterocyclic Carboxylic Acids with (Hetero)aryl Halides.
Authors: Messaoudi Samir , Brion Jean‐Daniel , Alami Mouad
Published: June 2012

The procedure can be applied to a broad spectrum of quinoline substrates and even extended to analogous systems such as (XII) and (XV).
ChemInform Abstract: A New Practical Approach Towards the Synthesis of Unsymmetric and Symmetric 1,10‐Phenanthroline Derivatives at Room Temperature.
Authors: Cheng Yongfeng , Han Xuesong , Ouyang Huangche , Rao Yu
Published: June 2012

A new protocol for the synthesis of unsymmetric and symmetric 1,10‐phenanthroline derivatives (III) and (VII) is reported.
ChemInform Abstract: Concise Route to a Series of Novel 3‐(Tetrazol‐5‐yl)quinoxalin‐2(1H)‐ones.
Authors: Gunawan Steven , Nichol Gary , Hulme Christopher
Published: June 2012

A three‐step sequence is developed for the synthesis of compounds (V) via Ugi‐azide multi‐component reaction, simultaneous N‐deprotection followed by intramolecular cyclization and oxidation.
ChemInform Abstract: Construction of Novel Tricyclic Fused‐Ring Systems by the Multicomponent Reactions of Imidazo[1,5‐a]pyridine Carbenes with Aromatic ortho‐Dialdehydes and Electron‐Deficient Alkynes.
Authors: Yan Cai‐Xia , Sun Zhong‐Xin , Cheng Ying
Published: June 2012

The process results in formation of diastereomeric mixtures of novel tricyclic azepine derivatives (IV) and (V).
ChemInform Abstract: Stereoselective Hydrogenation of Dibenzo‐18‐crown‐6 Catalyzed by Carbon Nanotube‐Supported Rhodium Nanoparticles.
Authors: Liu Hsin‐Wang , Pan Horng‐Bin , Tian Guo‐Xin , Chen Hsing‐Jung , Chiu Kong‐Hwa , Jen Jen‐Fon , Lo Jiun‐Guang , Wai Chien M.
Published: June 2012

Multiwalled carbon nanotube‐supported Rh nanoparticles, prepared by a simple sonochemical method, are highly active for catalytic hydrogenation of dibenzo‐18‐crown‐6 to dicyclohexyl‐18‐crown‐6.
ChemInform Abstract: Ir(I)/HCl‐Catalyzed Head‐to‐Tail Homocoupling Reactions of Vinylsilanes.
Authors: Park Jung‐Woo , Park Sung Joon , Jun Chul‐Ho
Published: June 2012

The synthetic utilities of the dimer (IIa) are investigated for some transformations.
ChemInform Abstract: Palladium‐Catalyzed Regio‐ and Stereoselective Hydrosilylation of Electron‐Deficient Alkynes.
Authors: Sumida Yuto , Kato Tomoe , Yoshida Suguru , Hosoya Takamitsu
Published: June 2012

Various alkynes can be used as substrates for the title process.
ChemInform Abstract: Highly Efficient Hydrophosphonylation of Aldehydes and Unactivated Ketones Catalyzed by Methylene‐Linked Pyrrolyl Rare Earth Metal Amido Complexes.
Authors: Zhou Shuangliu , Wu Zhangshuan , Rong Jiewei , Wang Shaowu , Yang Gaosheng , Zhu Xiancui , Zhang Lijun
Published: June 2012

New dinuclear rare earth metal amido complex SAC bearing methylene‐linked pyrrolylamido ligands is effectively used for hydrophosphonylations of aromatic and aliphatic aldehydes (I) whereas, complex YPC gives better results for unactivated aliphatic, (hetero)aromatic ketones (IV).
ChemInform Abstract: Arbuzov‐Type Reaction of Acylphosphonites and N‐Alkoxycarbonylimine Cations Generated in situ with Trifluoroacetic Anhydride.
Authors: Dmitriev Maxim E. , Ragulin Valery V.
Published: June 2012

The use of biscarbamates as stable synthetic equivalents of unstable aldehydes renders possible a mild and efficient access to the target compounds, which represent N‐protected phosphinic α,α′‐pseudo dipeptides.
ChemInform Abstract: An Enantiospecific Synthesis of a Crinipellin.
Authors: Srikrishna A. , Gowri V.
Published: June 2012

Starting from readily available (S)‐campholenaldehyde (S)‐(I), an enantiospecific synthesis of the tetraquinane framework of crinipellin is presented.
ChemInform Abstract: Synthesis and Biological Evaluation of Antitumor‐Active Arglabin Derivatives.
Authors: Csuk Rene , Heinold Anke , Siewert Bianka , Schwarz Stefan , Barthel Alexander , Kluge Ralph , Stroehl Dieter
Published: June 2012

Some arglabin derivatives with variations at the endo‐ or exocyclic double bond are synthesized and screened for their cytotoxicity.
ChemInform Abstract: Cytotoxic Terpenoids from Juglans sinensis Leaves and Twigs.
Authors: Yang Heejung , Cho Hyun‐Jong , Sim So Hee , Chung Young Keun , Kim Dae‐Duk , Sung Sang Hyun , Kim Jinwoong , Kim Young Choong
Published: June 2012

Three new triterpenes and two new sesquiterpenes (IV), (V) are identified.
ChemInform Abstract: Progress in the Synthesis of (‐)‐α‐Kainic Acid.
Authors: Choony Nandeo , James Lisa , Rabun Courtney
Published: June 2012

Starting from L‐serine, the first steps of a contemplated stereocontrolled synthesis of (‐)‐α‐kainic acid are described leading to key intermediate (V) in enantiomerically pure form.
ChemInform Abstract: Synthesis and Characterization of Novel Bi‐ and Tricyclic α‐Amino Acids.
Authors: Mangette John E. , et al. et al.
Published: June 2012

The synthesis of 9 novel bi‐ and tricyclic α‐amino acid derivatives such as (VII) or (XV) is described.
ChemInform Abstract: New Cyclic Peptides with Osteoblastic Proliferative Activity from Dianthus superbus.
Authors: Tong Yun , Luo Jian‐Guang , Wang Rui , Wang Xiao‐Bing , Kong Ling‐Yi
Published: June 2012

Dianthin G (I) and dianthin H (II) are isolated along with known dianthin E from the traditional Chinese medical plant Dianthus superbus.
ChemInform Abstract: Dehydrogenative Heck Coupling of Biologically Relevant N‐Heteroarenes with Alkenes: Discovery of Fluorescent Core Frameworks.
Authors: Huang Yumin , Song Feijie , Wang Zhen , Xi Peihua , Wu Ningjie , Wang Zhigang , Lan Jingbo , You Jingsong
Published: June 2012

An efficient Pd/Cu bimetallic catalyst system for the direct alkenylation of biologically relevant N‐heteroarenes (I), (IV), and (VI) with alkenes (II) is described.
ChemInform Abstract: A General Regioselective Approach to 2,4‐Disubstituted Pyrimidin‐5‐yl C‐2‐Deoxyribonucleosides.
Authors: Kubelka Tomas , Slavetinska Lenka , Hocek Michal
Published: June 2012

A general strategy allows to synthesize a broad spectrum of title compounds via nucleophilic displacement of 2,4‐dichloropyrimidine nucleoside substrates as is demonstrated by some selected examples in the scheme.
ChemInform Abstract: Efficient Synthesis of 1‐Deaza‐6‐methoxypurine‐N9‐β‐2′‐deoxyribonucleoside and Related DNA Building Blocks.
Authors: Megger Dominik A. , Mueller Jens
Published: June 2012

The synthesis of title compound (III) is significantly improved by modifying the deprotection/substitution procedure.