bluuebunny/crossref_metadata_2025 huggingface dataset:
A Study of Methanol Seed Extract of Lepidium Sativum Effect on Some Entero Bacteria and Fungi (Asparagillus Niger)
Authors:   Ministry of Education, Directorate Najaf Education, Najaf, Iraq., Al-Ghufaili Melath K. , Hassan Shurooq F. ,   Genetic Engineering Department, College of Biotechnology, University of Al-Qassim Green, Iraq., Abbas Shaymaa A. ,   Ministry of Education, Directorate Najaf Education, Najaf, Iraq.
Published: December 2023

The results of the current study indicated the effect of methanol seed extract at a concentration of 200mg/ml there was a variation effect of L. sativum methanol seed extract against the studied bacteria, in the diameter of the inhibition zone with diver’s bacterial strain Staph. aureus gave the highest inhibition zone value was 26mm at 1ml of L. sativum methanol seed extract while E. coli and E. faecelis did not give any inhibition zone at 0.12 ml of L. sativum methanol seed extract, there was a variation of effect among gram-negative and positive bacteria in their response to different solvent seed extracts. There was a variation effect in the antifungal activity of the methanol seed extract against Aspergillus niger the results established the methanol seed extract appeared the differences in their antioxidant activity and diverse variety. It was variation in the activity in relation to concentration (activity decrease with decrease extract concentration), Seed extract showed antioxidant activity in this study, the anti-oxidation effect of the L. sativum seeds extract by methanol, which give the highest percentages at concentration 1mg, reaching 91.419 and the lowest value at concentration 0.12, which amounted to 81.308. The present study deals with, antimicrobial properties and Anti-oxidant activity constituents of Gc seeds.
Use of probiotics in treating psychiatric and neurological disorders
Authors: Saiyeda Maha Fatima  , Areeb Khan  , Bushra Asghar
Published: December 2023

To the Editor,
The gut-brain axis is a bidirectional pathway through which the central nervous system and gut microbiota communicate. Metabolites from the gut microbiota can interact with ANS gut synapses, similarly, gut physiology can be controlled by the ANS. Visceral sensory signals from the gut travel to the CNS via the vagus nerve and can influence mood changes. Any alterations in this complex pathway can lead to the development of several gastrointestinal, psychiatric, and neurological disorders that include depression, anxiety, Alzheimer’s disease and Parkinson’s disorder [1-2]. As the relationship between psychiatric and gastrointestinal symptoms becomes well-established with 60% of patients with gastroenterological complaints having psychiatric origins [3], the question arises of whether it would be beneficial to focus on the gut microbiota and use probiotics to treat psychiatric and neurological ailments.
Recent research has opened a new door to targeting the gut microbiota to treat disorders such as depression, anxiety, Alzheimer's disease, Parkinson's disease, and autism spectrum disorder [1]. The effect of modifying gut microbiota to treat psychiatric illnesses that include depression, anxiety, and schizophrenia has been studied, showing that the use of probiotics can alleviate depression but has no effect on schizophrenia. The gut microbiota influences the hypothalamic-pituitary-adrenal axis, allowing probiotics to alter the stress response of cortisol; however, sufficient data is not available to comment on the effect of probiotics on anxiety [4]. Furthermore, the scope of probiotics seems to extend beyond mood disorders to relieving symptoms of neurological disorders that include Parkinson’s, migraine and epilepsy [5]
The close relationship of gastrointestinal and neuropsychiatric health often results in disorders of both systems appearing concomitantly and GIT manifestations are often dismissed as being caused by the psychiatric complain; however, we may look at the other side of the picture which is that gastrointestinal dysbiosis may be a cause or an exacerbating factor of the neuropsychiatric symptoms in which case probiotics can be a reliable treatment. More evidence needs to be obtained on their effectiveness and whether they may be used as stand-alone or along with other medications.
Incidence of infection in carpal tunnel surgery with and without the use of local antibiotics
Authors: Bilal Khan  , Alam Ikram , Ullah Sajjad , Jamal Bakht
Published: December 2023

Objective: To compare the infection rate in patients who underwent carpal tunnel surgery with and without instilling local antibiotics into the surgical wound.
Method: The retrospective cohort study was conducted at the Department of Surgery, Unit of Neurosurgery, Government Naseer Ullah Babar Memorial Hospital, Peshawar, Pakistan, and comprised data from July 2019 to July 2021 related to non-diabetic patients without any comorbidity who had undergone fresh carpal tunnel surgery. The cases had been operated by two surgeons having a different approach to preventing infection in carpal tunnel surgery cases. The surgeon in group A did not use any local antibiotics after completing the surgery, while the surgeon in group B instilled local gentamicin in the open wound for 3 minutes after completing the nerve release. All patients were put on oral antibiotics for a period of 5 days after the procedure in both the cohorts, and were assessed fortnightly for any infection and removal of stitches. Demographics of the patients, use of antibiotics and the occurrence of infection were recorded on a proforma. Data was analysed using SPSS 20.
Results: Of the 177 patients operated during the period, 13(7.3%) was discarded owing to missing data. Of the 164(92.7%) patients analysed, 138(84.14%) were females and 26(15.85%) were males. The overall mean age was 32.46±8.97 years. The total surgeries conducted were 176; 96(54.54%) in group A and 80(45.45%) in group B.  Infections were found in 3(1.7%) patients; all in group A (p=0.160).
Conclusion: Although not statistically significant, instillation of local antibiotics may play a role in preventing surgical site infections in carpal tunnel surgery cases.
Key Words: Topical antibiotics, Local antibiotics, Carpal tunnel surgery, Gentamicin, Infection.
Comparison of thrombomodulin, vWF, and ADAMTS13 levels between preeclampsia and normal pregnancy
Authors: Ahmad Aisha , Mustafa Ghulam , Mazari Nazish , Asif Muhammad
Published: December 2023

Objective: To determine and compare plasma thrombomodulin, von Willebrand factor and von Willebrand factor-cleaving protease levels between pre-eclamptic and healthy pregnant females.
Method: The cross-sectional, comparative study was conducted at the Department of Haematology, University of Health Sciences, Lahore, Pakistan, from November 2019 to December 2020, and comprised pregnant females who were divided into healthy pregnant group A and pre-eclamptic group B. Plasma thrombomodulin and von Willebrand factor-cleaving protease levels were determined by using commercially available enzyme-linked immunosorbent assay kit, and von Willebrand factor level was determined by using immuno-turbidimetric assay kit. Data was analysed using SPSS 25.
Results: Of the 88 participants, there were 44(50%) females with mean age 25.5±6 years in group A and 44(50%) in group B with mean age 26±5 years. Median thrombomodulin level in group B was significantly higher than group A (p=0.003). Median von Willebrand factor-cleaving protease levels were lower in group B compared to group A (p=0.838). A significant difference in von Willebrand factor level was observed between the groups (p=0.038).
Conclusion: Females with pre-eclampsia had significantly higher plasma levels of von Willebrand factor and thrombomodulin than healthy pregnant subjects.
Key Words: Thrombomodulin, vWF, ADAMTS13 protein, Pre-eclampsia.
Effectiveness and safety of intravesical Gentamicin therapy in patients with recurrent urinary tract infections caused by multidrug resistant organisms
Authors: Malik Zubda
Published: December 2023

A prospective study was conducted at the Liaquat National Hospital and Medical College, Karachi, to determine the effectiveness, feasibility, and safety of intravesical Gentamicin therapy among patients presenting with recurrent urinary tract infections (rUTIs). All patients aged 15 years, who presented with recurrent UTI, having 3 positive urine cultures, with neurogenic bladder, intermittent catheterisation, symptomatic UTIs, and multidrug resistant cultures, were included in the study. Data were compiled and analysed using SPSS version 26. An ethics committee approved the study. A total of 69 patients were enrolled. Most common organisms were Klebsiella (52.2percent), E. coli (27.5percent) and gram -ve bacilli (14.5percent).
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Familial focal segmental glomerulosclerosis associated with a WT1 gene missense mutation: a case report
Authors: Ko Yun Jung , Rhie Seonkyeong , Baek Jihyun , Seo Go Hun , Lee So-Young
Published: December 2023

Focal segmental glomerulosclerosis (FSGS) can cause proteinuria and loss of kidney function, leading to end-stage renal disease (ESRD). Podocyte injury is the central pathophysiological mechanism of hereditary FSGS. Numerous mutations in genes encoding or affecting the transcriptional regulation of podocyte cell compartments have been detected in patients with genetic FSGS. Herein, we report a rare case of familial FSGS with an autosomal dominant WT1 mutation. A 63-year-old man developed proteinuria; his reading showed over 1g protein/day. A pathological diagnosis of FSGS was made after renal biopsy. His elderly brother and a 36-year-old son also had ESRD.  Heterozygous variant of WT1 (NM_024426.4) c.1373G>A (p.Arg458Gln) missense was detected in the patient and his son, by whole-exome sequencing. Although genetic screening is not a part of routine practice, it should be performed in such cases to aid appropriate treatment options selecting, revealing extrarenal symptoms, and family planning.
Comparing the effects of trunk stabilisation and activation exercises on pain and disability in postpartum lumbo-pelvic pain (randomised controlled trial)
Authors: Chaudhry Rabia Yousaf , Muneeb Hafiza Neelam , Ameena Amjad  , Shafique Sidra , Naseem Aqsa , Shahzadi Nafisa
Published: December 2023

The purpose of this study was to determine and compare the effects of trunk stabilisation and activation exercises on pain and disability in postpartum lumbo-pelvic pain. It was a randomised clinical trial (ClinicalTrials.gov: NCT05490810). Twenty-eight females with lumbo-pelvic pain were randomly allocated to two groups with 14 patients in each group. Group A was treated with trunk stabilisation exercises and Group B was treated with trunk activation exercises, three times a week for eight weeks. Numeric pain rating scale was used to measure the intensity of pain. Disability was assessed through Oswestry disability index (ODI). Both the groups were evaluated before and at the end of the last treatment session. Data was analysed by SPSS 21. There was a significant difference between trunk stabilisation versus activation exercises on pain and disability in postpartum lumbo-pelvic pain with p value <0.05 in Group A patients.
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Crohn's disease with multiple jejunum and ileum lesions: a case report
Authors: Zhang Dong , Chen Nan , Yang Jie , Guo Shaoju
Published: December 2023

Crohn's disease (CD) affecting the jejunum and ileum is uncommon and its diagnosis can be challenging. This case report describes a 35 year old male patient who had been experiencing intermittent periumbilical pain, diarrhoea and fever for five years. Despite undergoing gastroscopy, colonoscopy and capsule endoscopy; no significant abnormalities were found. This case was seen at the Shenzhen Hospital of Traditional Chinese Medicine; Shenzhen, China. However, the patient underwent a double-balloon enteroscopy (DBE), which revealed multiple ulcers in the jejunum and ileum, leading to a confirmed diagnosis of CD. The patient was successfully treated with infliximab to relieve symptoms. DBE can be particularly valuable in diagnosing CD in young patients with symptoms when conventional endoscopic techniques have been unsuccessful. This case highlights the importance of considering small bowel disease in patients with CD symptoms and the potential benefits of DBE in diagnosing such cases.
Attitudes toward and management of fibromyalgia: a national survey of Saudi Arab’s medical practitioners
Authors: Mubaraki Adnan Ali , Abdulaziz Reham Ahmed , Altalhi Thekra Matoq , Kabrah Lama Kamal , Althagafi Atheer Musaad , Alsufyani Raghad Ali , Althubaiti Shahad Waslallah
Published: December 2023

Widespread pain is characteristic of fibromyalgia. Patients consult different specialities, and hence, diagnosis and treatment is often delayed. To evaluate and assess the attitudes and management of fibromyalgia among medical practitioners in Saudi Arabia a cross-sectional study was conducted through an online questionnaire in November 2021. Screening demographics included age, sex, place of work, speciality, year of graduation, and practical experience. Questions about fibromyalgia (general knowledge and management, ACR criteria 2010, essential symptoms, diagnosis, and treatment) were also part of the questionnaire. There were 103 respondents, out of which 88(85.4%) have heard about fibromyalgia and 21(20.4%) had managed cases of fibromyalgia, while 32(31.1%) knew about the 2010 ACR diagnostic criteria. Commonest reported characteristics of fibromyalgia were excessive fatigue 74(71.8%), widespread pain 71(68.9%), weakness 54(52.4%), and sleep disturbance 38(36.9%). About 76(73.8% reported it is a clinical diagnosis and 75(72.6%) reported having the knowledge about the treatment of fibromyalgia.
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Analysis of impact of consumption of proton pump inhibitor on osseointegration of dental implants to the alveolar bone -a systematic critical appraisal
Authors: Lal Abhishek , Umer Fahad , Parkash Om
Published: December 2023

Proton pump inhibitors are one of the most frequently prescribed medicines primarily for reducing the production of gastric acid. Every medicine has some adverse effects associated with it, including effects on the bone tissues. Dental implant is one of the most preferred options for teeth replacement. The current literature review was planned to evaluate the association between intake of proton pump inhibitors and its impact on the bone around the dental implant. Literature review entailed search on Google Scholar, Web of Science and PubMed databases using a range of search terms. Chronic intake of proton pump inhibitors has been associated with decrease in the density of bone, which eventually leads to increased risk of dental implant failure. However, since limited studies have been carried out, further research is required, especially clinical trials, to evaluate the relationship between the intake of proton pump inhibitors and the failure of dental implants.
Excessive usage of social media: a potential threat to mental health in Pakistan
Authors: Zafar Habiba , Muhammad Bin Mobin
Published: December 2023

Madam,
Social media is an interactive technology that has been used for decades across the globe and Pakistan has millions of active users as well. Social media platforms have experienced rapid growth in Pakistan, with approximately 53 active million users in 2021, reflecting a 9.2% increase from the previous year [1]. While these platforms provide numerous benefits such as connectivity, information dissemination, and social support, they also pose risks to mental health and wellbeing. Studies have linked excessive social media use with increased levels of anxiety, depression and sleep disturbances [2].
The alarming increase in social media usage is a potential threat to the mental health and our population, particularly among young people. A study conducted on Pakistani university students revealed that excessive use of social media was significantly associated with increased stress, anxiety, and depression [3]. Furthermore, the prevalence of cyber bullying in Pakistan has now become a valid concern. One study estimating that most of Pakistani internet users, especially youth have experienced some form of cyberbullying [4]. Cyberbullying is a significant risk factor for mental health issues, including anxiety, depression, and suicidal ideation. Addiction to social media ultimately leads to exposure to a lot of harmful content; a study also showed that memes, cyber mobs and pranks are a common source of cyber-bullying causing more damage to the mental health of Pakistani students [5].
An extensive study also suggested the negative relationship between addiction of social media and mental health; users tend to have low self-esteem and confidence. Another disadvantage of excessive usage of social media is media violence; there is a lot of anger on media that can impact the mental health [6].
Given the potential impact of social media on mental health of Pakistani youth, the government should implement public awareness campaigns highlighting the potential risks of excessive social media usage and promoting healthy online behaviours. People who have already been diagnosed with any kind of mental illness due to excessive usage of social media should be properly treated and provided with therapies. More research on the impact of social media on mental health and well-being in Pakistan, this will help identify specific risk factors, protective factors and intervention strategies relevant to the Pakistani context.
Pozitivist Modern Dünya Görüşü ve Kur'ân’ın Genel Kabulleri Bağlamında Başarılı İnsan Portresine Mukayeseli Bir Bakış
Authors: ÇELİKEL Fatih
Published: December 2023

Başarı bazı kriterlere göre yapılan değerlendirmenin neticesinde ortaya konulan olumlu sonuçtur. Bu konudaki kriterlerin değişmesi, insanın başarı durumu değerlendirmesini doğrudan etkileyecektir. Günümüz dünyası genel itibariyle modern bakış açısının hâkim olduğu bir dönemi yaşamaktadır. Bu yüzden insan başarısı ile ilgili değerlendirmeler genellikle bu bakış açısı üzerinden yapılmaktadır. Modern dönemin kutsaldan uzaklaşan algısında varlık, maddeden ibaret olduğu için, başarının en birinci kriteri de maddî kazanımlardır. Ancak Kur'ân’ın varlık tasavvuruna göre madde, varlığın sadece bir boyutudur. Bu sebeple Kur'ân’ın başarı kriterleri, kutsalı ve metafiziği dışlayan modernitenin kabul ettiği kriterlerden farklıdır. Bu durumda başarılı insanın hangi özellikleri taşıması gerektiği konusu gündeme gelmektedir. Bu makalede, modernitenin sadece maddeyi temele alan dünya görüşü bağlamında Kur'ân’ın değerler manzumesi ve çizdiği başarılı insan profili mukayeseli bir bakış açısıyla incelenmektedir. Bu inceleme özellikle özgürlük, iyi/doğru iş, başarı, şehitlik gibi kavram ve değerlerin Kur'ân’daki ve pozitivist modern düşüncedeki karşılıkları üzerinden yapılmaya çalışılacaktır. Çalışmanın genelinde tespit, analiz ve mukayese yöntemleri kullanılmaktadır. Bu çalışma ile teoride modernite ve Kur'ân’ın genel anlayışları içerisinde başarı kriterlerinin neler olduğunun tespit edilmesi, böylelikle modern zamanlarda yaşayan günümüz insanına hayatını hangi anlayış ve değerler üzerine inşa ettiği ile ilgili bir tahkik imkânı sunulması amaçlanmaktadır.
Staffing of doctors in primary health care in Russia
Authors: Khodakova Olga V. , Senotrusova Yulia E. , Deev Ivan A. , Kobyakova Olga S.
Published: December 2023

Introduction. A sufficient level of staffing for primary health care is the availability of primary health care for the population. Despite qualitative changes in the healthcare system, the shortage and imbalance of medical personnel in the provision of primary health care is a significant problem.
The purpose was to analyse the main trends in the provision of the health care system of the Russian Federation with physicians providing primary health care for the period 2018–2022.
Methods and material. Statistical, analytical, method of comparative analysis, federal statistical observation No. 30 “Information on a medical institution” for 2018–2022 were used.
Results. During the analysed period, there was a slight decrease in the provision of doctors providing primary health care on an outpatient basis. The staffing of full-time medical positions by individuals in outpatient settings in the Russian Federation increased by 2.1%, and the part-time ratio decreased by 4%, which is a favourable trend.
The level of provision with doctors of the local service differs in the federal districts. In the Russian Federation, there was noted a positive trend in terms of provision with district general practitioners and paediatricians.
The provision of general practitioners, on the contrary, is declining.
Limitations. The research materials are limited to the results of the analysis of the data of the federal statistical observation No. 30 for the federal districts and the Russian Federation as a whole.
Conclusions. There were identified main trends in the availability of doctors providing primary health care in outpatient settings. The shortage and imbalance of personnel in the system of primary health care continue to persist, which requires a comprehensive study of the problem of staffing.
Population prevalence determined by environmental factors as additional burden on the public healthcare and a factor causing economic losses in regions
Authors: Zaitseva Nina V. , May Irina V. , Kiryanov Dmitry A.
Published: December 2023

Introduction. Regions where both ecological and sanitary-hygienic situation is unfavorable tend to have growing incidence and more frequent applications for medical aid by population in Russia and worldwide as well.
The purpose of this study was to assess population incidence in different regions in the country associated with poor quality of the environment as a factor creating additional burden on public healthcare institutions in a given region and probable economic losses in it.
Materials and methods. We applied data of state medical and sanitary-hygienic statistics over 2013–2021. Medical and demographic losses associated with exposure to harmful environmental factors were quantified using step-by-step regression analysis modified by enumeration of functions for independent variables. Economic losses were estimated for diseases and deaths among population involved in producing gross regional product.
Results. We were able to obtain more than one hundred authentic models that provided a quantitative association between population prevalence and violations of hygienic standards regulating quality of the environment. We established that between 2.9 and 5.8 million diseases associated with environmental factors were annually detected in the country over the last 10 years. Burden on regional healthcare systems grew in regions with obviously high levels of pollution in ambient air and drinking water; this gain grows up to 12.55%. In 2021, losses of gross regional products due to diseases and deaths caused by violations of hygienic standards regulating quality of the environment exceeded 170.6 billion rubles.
Limitations of the study. A set of factors included into modeling can be considered a certain limitation of the present study.
Conclusion. It seems quite relevant to coordinate efforts by different ministries and departments in the sphere of public health protection in Russia. It is also advisable to consider a peculiar sanitary-hygienic situation in a given region when calculating scopes of necessary funding for a regional healthcare system. Development of public-private partnerships seems another vital trend in health protection within efforts aimed at reducing impacts on the environment and implementing medical and prevention programs for population.
Medical and management approaches to the examination of hereditary cancer syndrome patients and their relatives
Authors: Byakhova Maria M. , Parts Sergey A. , Semenova Anna B. , Kuzmina Evgenia S. , Didenko Vera V. , Galkin Vsevolod N. , Gadzhieva Saida M.
Published: December 2023

Introduction. Genetic testing has become the part of the practice of providing specialized cancer care. This allows not only detecting the further tactics for patient management, but also identifying a risk group for the occurrence of malignant neoplasms (MNP). However, there are still no algorithms for dispensary monitoring of healthy carriers of mutations, which determined the relevance of our study.
The purpose of the study was to propose an organizational model for the work of the office of hereditary tumor pathology (HTP) based on the analysis of our own experience in identifying patients with hereditary oncological syndromes and their relatives as potent carriers of mutations associated with an increased risk of occurring MNP.
Materials and methods. Genetic testing was carried out in two thousand two hundred seventy six patients (residents of Moscow) with breast, gastrointestinal tract, and ovarian cancer.
Results. 714 patients out of 2276 MNP patients had mutations associated with an increased risk of developing cancer. Further, 277 relatives of these patients were invited, and mutations were detected in 143 (51.7%). Based on these data, an management model of the HTP office was proposed as part of the Outpatient Oncology Center (OOC), and the need for specialists to work in the HTP office per 100 thousand people was determined —
0.06 oncologist’s rate, 0.03 doctor’s rate-genetics and 0.03 psychologist rates.
Limitations. This study did not include patients who did not meet the selection criteria, as well as persons under 18 years of age or who isn’t resident of Moscow.
Conclusion. The introduction of genetic testing of patients’ relatives into practice will allow forming risk groups for subsequent dispensary observation, early detection of tumor and precancerous pathology.
Assessment of the relationship of the morbidity rate of the adult population in the Sverdlovsk region with the staffing of medical staff
Authors: Akulin Igor M. , Ionkina Irina V.
Published: December 2023

Analysis of indicators of primary and general morbidity of the population plays a decisive role in the management strategy in the healthcare system. It is necessary for developing management decisions at all levels of government. Evaluation of the results of this study allows optimal planning and forecasting of the development of various health care indicators, including the staffing level of medical personnel.
The purpose of the study is to assess the relationship between morbidity among the adult population of the Sverdlovsk region and the level of medical staffing.
Materials and methods. statistical materials from the annual collection “Health of the population of the Sverdlovsk region and the activities of medical organizations” were used: statistical reporting data on the morbidity of the population, staffing with medical personnel.
Results. In the Sverdlovsk region, over 2017–2021 a gain in primary morbidity among the adult population accounted for 33.1% and an increase in overall incidence — 9.4%. The medical staffing level for 2021 (61%) was by 6.1% lower than during 2017 (65%). When assessing the impact of medical staffing on the morbidity rate using correlation analysis, a strong inverse relationship between these indicators was revealed.
Limitations. When studying the morbidity rate of the adult population of the Sverdlovsk region, an analysis of data from FFSN No. 12 and No. 30 for 2017–2021 was carried out.
Conclusions. The identified problems can negatively affect the availability and quality of medical care provided to the population, lead to an increase in primary and general morbidity rates, as well as a decrease in their labour potential. The results we obtained require appropriate attention and subsequent management decisions in matters of training and attracting medical personnel, which should be based on systemic measures aimed at eliminating personnel shortages.
Features of immunological indicators in children with allergy modified by nickel contamination of biomedia and polymorphism of CPOX rs1131857 detoxification gene
Authors: Shirinkina Alisa S. , Dolgikh Oleg V.
Published: December 2023

Introduction. The impact of unfavourable environmental chemical factors on the human immune system predetermines the conditions for the formation of pathological conditions associated with allergies.
The purpose of the study. To study the features of immunological indicator parameters in children with allergies modified by contamination of biological media with nickel and polymorphism of the detoxification CPOX rs1131857 gene.
Materials and methods. A study was conducted one hundred eighty children suffering from various forms of allergies, permanently residing in the zone of the Far North (121 of them — under conditions of aerogenic exposure to nickel aerosols, and 59 children — in a “conditionally clean” territory). The subject of the study was biological media (blood). The change in the content of specific IgE to nickel was determined by an allergosorbent test with an enzyme label. The study of cell differentiation clusters included the use of flow cytometry (CD3+, CD19+, CD3+CD4+, CD3+CD8+, CD16+CD56+). Polymorphism of the CPOX (rs1131857) gene was studied by real-time polymerase chain reaction (PCR).
Results. The analysis of the immune and genetic status of children with various manifestations of allergic pathology revealed cellular immunodeficiency (CD3+ CD4+, a decrease in the immunoregulatory index), the development of processes of hypersensitivity to chemical technogenic haptens (IgE to nickel), as well as an increased frequency of occurrence of heterozygous AC polymorphism of the second detoxification gene. phase CPOX rs1131857, verified by significant parameters of inheritance models (OR = 2.83; 95% CI: 1.14–7.01;
p < 0.05).
Limitations. The present study is not exposed to the adult population, does not consume the population, and does not consume, except in the Far North.
Conclusion. A feature of the course of allergic pathology in the children’s population of the Arctic, modified by contamination of biomedia with nickel and polymorphism of the detoxification CPOX rs1131857 gene, will be an increased frequency and duration of recurrence of allergopathology due to the addition of viral (decrease in cellular immunity) and hapten (nickel) components.
Trends in prevalence among children in secondary schools under the contemporary educational process and exposure to environmental factors
Authors: Valina Svetlana L. , Shtina Irina E. , Ustinova Olga Yu. , Maklakova Olga A.
Published: December 2023

Introduction. Trends in of schoolchildren’s health highlights the importance of performing complex estimates aimed at identifying what influence of the contemporary education process and environmental factors have on prevalence among children and adolescents.
Materials and methods. The research involved examining data obtained by a profound medical examination of three hundred thirty nine schoolchildren attending municipal secondary schools with different educational programs. In this research, the test group (146 schoolchildren who attended a gymnasium) and the reference group (193 schoolchildren who attended an ordinary secondary school) were divided into several sub-groups based on their age group. We analyzed data of medical and social questioning, ‘Weekly Rations of a school student’ and school schedules covering classes and breaks between them. All the data were analyzed using conventional statistical procedures and logistic modelling together with calculation of relative risks.
Results. We established different ratios of harmful components related to the educational process, lifestyle, diets, and the environment in schools with different educational programs. This fact indicates the examined exposure to be multi-factorial and determines some peculiarities of incidence and unfavourable age periods in clinical courses of diseases among schoolchildren attending a gymnasium or an ordinary secondary school. Causation of negative health outcomes in schoolchildren by lifestyle factors equaled R2 = 0.11–0.86;
the educational process, R2 = 0.10–0.84; environmental factors, R2 = 0.13–0.58.
Limitations: a rather small sample.
Conclusion. Schoolchildren in gymnasium have 3.1–4.8 higher risks of diseases of the endocrine and musculoskeletal system in primary school; diseases of the nervous system, in senior school; ophthalmic pathologies, during the whole school period. Likelihood of digestive diseases and diseases of the musculoskeletal system grows by 4.6–41.0 times in middle and senior school. Greater effectiveness of medical check-ups and timely identification of risk factors are the most important tools for creating an integral preventive environment.
Morbidity rates of the children population under conditions of aerogenic chemical exposure: risk factors and associations
Authors: Koldibekova Yuliya V. , Zemlyanova Marina A. , Goryaev Dmitry V. , Chetverkina Kristina V.
Published: December 2023

Introduction. In the the industrialized regions of the Russian Federation one of the hygienic problems is the formation of additional morbidity among the population associated with intense air pollution.
The purpose of the work is to study the health disorders in children under conditions of aerogenic chemical exposure in terms of primary morbidity.
Materials and methods. Analysis of the primary morbidity of the children population (data from state statistical reporting and actual seeking medical care in 2017–2021); the content of the main chemical pollutants in the atmospheric air in residential buildings (data from social and hygienic monitoring and the regular observation network of Roshydromet for 2016–2020 according to the content of twenty two impurities); chronic non-carcinogenic risk; connection of diseases with aerogenic chemical exposure according to epidemiological indicators; economic assessment of predicted losses.
Results. Comparing to the reference area, the level of primary morbidity in children with diseases of the respiratory system, digestion, kidneys, nervous system, osteoarticular apparatus, associated with aerogenic exposure to chemical pollutants, was established to be an increased by up to 3.4 times. In the atmospheric air of residential buildings, the content of a number of chemicals (metals, aromatic and fluorine-containing inorganic compounds) was found to be increased by 6.9 times and 4.0 times relative to the average daily and maximum one-time maximum permissible concentrations, respectively, and within the hygienic standards. The formed exposure causes an unacceptable risk of developing non-carcinogenic effects (HI up to 18.7 times) in relation to target organs. Additional morbidity in the children population (about 1.5 thousand cases per year) has been identified in the event of which the projected economic losses will amount to about 10 million rubles over year.
Limitations. The study includes the children population under the age of 14 years.
Conclusion. The primary morbidity of children in regions with developed industrial infrastructure is characterized by special random events associated with aerogenic exposure to risk factors. Projected additional losses require priority regulatory action.
Structural and functional changes in the arteries in young women living in the industrial region of the Far North under the aerogenic impact of chemical technogenic factors
Authors: Nosov Alexander E. , Ustinova Olga Yu.
Published: December 2023

Ambient air pollution is a significant risk factor for cardiovascular diseases.
Purpose of the work: to study the structural and functional characteristics of the carotid arteries in women living in the Far North under conditions of exposure to metals and particulate matter.
Materials and methods. Observation group consisted of seventy eight women living in the Far North in the zone of impact of metallurgical enterprises; comparison group included 20 women living in similar climatic conditions. Duplex scanning of the brachiocephalic arteries was used to evaluate the intima-media thickness (IMT), Peterson’s (Ep) and Young’s (Ym) elastic modules. The cause-and-effect relationships of vascular disorders with blood concentrations of nickel, copper, and chromium were studied.
Results. In the observation group the IMT thickness was greater than in the comparison group (0.55 (0.49;0.62) mm versus 0.46 (0.45;0.5) mm, p < 0.0001). In the observation group, Ep was 1.84 times and Ym was
1.52 times higher than the indicators in the comparison group. The relative risk of increasing IMT reached
2.1 (95% CI 1.1–4.3). An increase in the probability of IMT thickening was revealed with an increase in the blood chromium concentration (R2 = 0.10; p = 0.003), an increase in the values of Ep — copper (R2 = 0.15;
p = 0.002) and chromium (R2 = 0.19; p = 0.0002), and Ym values — copper (R2 = 0.39; p < 0.0001).
Limitations of the study. This study did not include middle-aged and elderly women, men, and did not include the population of territories other than the Far North.
Conclusions. Young women living in conditions of inhalation exposure to nickel, chromium, copper, and particulate matter experience an intensification of atherosclerotic and arteriosclerotic processes, manifested by an increase in IMT, atherosclerotic plaques, and an increase in the stiffness of the common carotid artery (CCA). A cause-and-effect relationship between the copper and chromium blood concentration and the probability of an increase in IMT, Ep and Ym has been established. The identified changes in the CCA make it possible to classify young women living in environmentally unfavourable areas as a higher category of cardiovascular risk.
Bronchopulmonary pathology in workers of modern oil refining production: significance and problems of the study (literature review)
Authors: Raikova Svetlana V. , Novikova Tamara A. , Komleva Nataliia E. , Trubetskov Alexey D.
Published: December 2023

Currently, the oil refining industry, as an integral part of the oil industry, makes a significant contribution to the economy of the Russian Federation and includes a significant contingent of workers exposed to a complex of harmful chemicals present in the air of the working area during the oil refining process. In this regard, the study of the prevalence of bronchopulmonary pathology in oil refinery workers is quite urgent task. The database of eLIBRARY.RU, Google Academy, CyberLeninka, Web of Science, Scopus and PubMed were used for the preparation of the literature review. It has been established that in the available modern scientific literature of the data devoted to the influence of oil hydrocarbons and oil products polluting the air of the working zone on functional disorders of the respiratory system in oil refinery workers could not be found. The most relevant studies on the effects of the chemical factor on the respiratory system in refinery workers have a significant statute of limitations and do not reflect current working conditions. The few data on the prevalence of respiratory diseases in workers in modern refineries are characterized by ambiguous results obtained by various authors. Thus, the issues of the influence of working conditions on the development of bronchopulmonary pathology among workers of modern oil refineries are extremely insufficiently covered. The results of the review indicate the relevance of both an in-depth study of the causes of the pathogenetic mechanism of bronchopulmonary diseases and prenosological diagnosis of respiratory pathology. So far, the main stage in the development of sound medical and preventive measures contributes to the preservation of health and prolongation of occupational longevity in workers employed in the oil refining industry.
Usûlî Âlim Vahîd el-Bihbehânî’nin Temel Görüşleri ve el-Fevâidü’l-Hâiriyye’sinde Ahbârîlere Yönelttiği Tenkitlerin Değerlendirilmesi
Authors: KUTLUAY İbrahim
Published: December 2023

Muhammed Bâkır Vahîd el-Bihbehânî (ö. 1206/1791-92) İran ve Irak’ta yaşamış; İslâm hukuku, hadis, kelâm ve felsefe gibi alanlarda eserleriyle Şiî düşünceye katkı sağlamış Şiî-Usûlî bir âlimdir. Usûlîliği yeniden sistematize eden Bihbehânî, Eş’arî ve Muʻtezilî kelâmını harmanlayarak akla ehemmiyet atfeden Bihbehânî Ekolünü kurmuştur. Otuz yıl Bihbehân’da kaldıktan sonra Kerbelâ’ya gelmiş ve orada hâkimiyet kurmuş olan Ahbârî ulemâ ile ilmî münakaşalar yapmıştır. Bihbehânî fikirleriyle susturmuş; bu sebeple mezkûr Ahbârî ulemânın bir kısmı Usûlîliğe geçmiş, bir kısmı ise Kerbelâ’yı terk etmek zorunda kalmıştır. Bihbehânî’ye Kerbelâ’da üstâd-ı kül ünvânı verilmiştir. Bihbehânî; Molla Mehdî Nerâkî, Seyyid Mehdî Bahru’l-Ulûm, Seyyid Mehdî, Şehristânî, Caʻfer Kâşifü’l-Gıtâ gibi müctehid seviyesinde Usûlî âlimler yetiştirmiştir. Bihbehânî’nin fıkıh usûlüne dair eserlerin yanında Şerhu’l-Mefâtih, Hâşiyetü’l-Medârik, Hâşiyetü’l-Vâfî, Hâşiyetü’l-Kâfî gibi kitapları da bulunmaktadır.

Bu makalede Bihbehânî’nin bilginin kaynağı ve değeri, ahbârın bilgi değeri, ictihad, ölü mercii ya da müctehidi taklid ve velâyet-i fakîhle ilgili görüşleri, onun el-Fevâidü’l-Hâiriyye adlı eseri esas alınarak incelenip değerlendirilecektir. Bununla İsnâaşerîlik içinde Ahbârîliğe karşı Usûlîliğin hâkim ekol hâline gelmesinde Bihbehânî’nin rolü ve velâyet-i fakîh teorisinin dinî yapıdaki fonksiyonun tahlil edilmesi amaçlanmaktadır.
Bostanzâde Yahyâ Efendi’nin Gül-i Sadberk’i İkinci Edisyonu Üzerine Bazı Mülahazalar
Authors: DEMİR Özlem
Published: December 2023

Türk İslâm Edebiyatı’nda Hz. Peygamber’in hayatı farklı yönleriyle işlenmiş ve bunun sonucunda ortaya çıkan yeni türlerde birçok eser yazılmıştır. Bu türlerden biri de “yüz yapraklı gül” mânasına gelen ve Hz. Peygamber’in yüz mûcizesini ele alan “Gül-i Sadberk”’tir. Anadolu ve Rumeli Kazaskeri olarak tanınmış olan Bostanzâde Yahyâ Efendi tarafından kaleme alınan eser, iki kez telif edilmiştir. Müellif, eserin ilk telifini Genç Osman’a, ikinci telifini de IV. Murad’a sunmuştur. Müellifin ikinci telifi oluştururken eser üzerinde büyük değişiklikler yaptığı görülmüştür. Eserin iki telifi arasındaki farkları ele alan bir çalışma şimdiye kadar yapılmamıştır. Bu çalışmanın amacı eserin ilk metnindeki tüm değişikliklerin saptanması ve bunun ikinci telife nasıl yansıdığının ortaya konmasıdır. Bu makalede eserin metninden örnekler verilerek eserin ikinci kez telif edildiğini gösteren âmiller belirtilmiş, müellifin eseri ikinci kez telif etmesinin sebepleri tespit edilmeye çalışılmış ve bu telifi oluştururken kullandığı yöntemler sıralanmıştır.
REVITALISASI MONUMEN PERS NASIONAL SURAKARTA MELALUI OPTIMALISASI PENGGUNAAN MEDIA SOSIAL
Authors: Putri Rahmadivya Ersa , Sa'idah Zahrotus
Published: December 2023

Monumen Pers Nasional (MPN) merupakan monumen dan museum tentang pers nasional di Indonesia, didirikan pada tahun 1978 yang terletak di Surakarta, Jawa Tengah . Untuk mendukung terbentuknya museum yang modern pemerintah melakukan revitalisasi fisik pada MPN dimulai pada tahun 2018. Revitalisasi museum merupakan sebuah pembaruan untuk meningkatkan kualitas museum sesuai dengan fungsinya dan dapat menjadi tujuan yang dirasakan sebagai kebutuhan untuk dikunjungi oleh masyarakat. Salah satu bentuk revitalisasi museum adalah dengan mulai menggunaan teknologi digital yang didukung oleh perkembangan teknologi informasi. Perkembangan industri yang berada pada revolusi industri 4.0 mendorong masyarakat untuk menggunakan platform digital. Salah satu bentuk revitalisasi yang dilakukan MPN yakni memanfaatkan platform digital Instagram sebagai wadah penyaluran informasi dan media branding MPN. Situasional Theory of Public (STP) merupakan teori yang mengidentifikasi publik sesuai dengan kategorinya. Teori STP membantu peneliti dalam mengidentifikasi publik sehingga membantu MPN dalam menentukan target marketnya agar pengelolaan media sosial berjalan optimal. Hasil dari penelitian mengungkapkan bahwa sosial media Instagram @monumenpers berjalan optimal, namun ada faktor hambatan yang perlu di perbaiki agar pengelolaan Instagram MPN tetap stabil.
HAK IMUNITAS DALAM PERSPEKTIF PRINSIP PERSAMAAN DERAJAT DI HADAPAN HUKUM
Authors: Rahmadani Rizky , Hufron Hufron
Published: December 2023

Abstrak Tujuan dari penulisan dan penelitian dari jurnal berjudul hak imunitas terhadap prinsip persamaan derajat dihadapan hukum ini adalah untuk mengetahui dan menjelasakan kedudukan hak imunitas yang dimiliki oleh anggota DPR. Hak imunitas merupakan suatu instrumen yang dianggap istimewa berupa pemberian hak kekebalan yang diberikan kepada anggota parlemen dalam menjalankan fungsi, tugas dan wewenangnya. Mengingat banyaknya tugas dan tingkat kerumitan dalam menjalankan tugas yang diberikan oleh negara. Tugas anggota DPR tidak hanya terbatas pada proses pembentukan Undang-Undang, akan tetapi terdapat juga tugas-tugas lain seperti fungsi anggaran yang tentunya dalam fungsi-fungsi tersebut terdapat hak-hak bagi anggota parlemen dalam menyampaikan pendapat. Hal tersebut menjadi objek menarik untuk dibahas mengingat dalam pelaksanaan fungsi dan tugas tersebut anggota DPR diberikan Imunitas (kekebalan) yang telah diamanatkan oleh UUD  NRI Tahun 1945 dan secara lebih lanjut diatur khusus dalam UU MD3. Hak imunitas diberikan dalam rangka menjaga kehormatan dan marwah lembaga negara, akan tetapi penggunaan hak imunitas yang dimiliki oleh DPR menjadi perdebatan di kalangan publik.  Masyarakat memiliki penafsiran tersendiri bahwasannya produk hukum di negeri ini dirasa masih diksriminatif dan hanya sebagian kalangan saja yang diberikan hak eksklusif tersebut selain itu hak tersebut juga menimbulkan perdebatan mengenai persamaan derajat bagi setiap warga negara dihadapan hukum. Masyarakat memiliki suatu pandangan bahwasannya pemerintah diwajibkan untuk tidak membedakan dan memberikan suatu bentuk perlakuan hukum terhadap warga negara, terlebih dalam kasus-kasus tertentu anggota DPR sering berlindung dibalik hak imunitas dan kewenangan Mahkamah Kehormatan Dewan bilamana terjadi gugatan hukum yang sedang menimpanya.Kesimpulan dari penulisan ini adalah Hak Imunitas yang terkandung dalam Pasal 245 Ayat (1) UU No.2 Tahun 2018 bertentangan dengan prinsip persamaan derajat di hadapan hukum.Kata kunci: Hak Imunitas, Dewan Perwakilan Rakyat, Prinsip Persamaan Derajat di Hadapan Hukum
ANALISIS FRAMING HARIAN REPUBLIKA DAN MEDIA INDONESIA PADA ISU PERMENDIKBUDRISTEK 30/2021 09-11 NOVEMBER 2021
Authors: Urfan Noveri Faikar , Setyawan Andika Bagus
Published: December 2023

Peraturan mendikbudristek 30/2021 tentang Pencegahan dan Penanganan Kekerasan Seksual di Lingkungan Perguruan Tinggi, menimbulkan pro dan kontra di media massa, khususnya di harian Republika dan Media Indonesia. Republika khawatir jika Permendikbudristek 30/2021, akan melegalkan seks bebas. Sementara Media Indonesia, menuntut agar peraturan itu segera diimplementasikan. Republika yang merepresentasikan pembaca Islam menganggap bahwa jika peraturan tersebut disahkan, maka hubungan seksual di luar pernikahan akan dilegalkan asal berdasarkan kesepakatan. Sementara Media Indonesia yang pemiliknya tergabung dalam koalisi pemerintah, menganggap bahwa peraturan tersebut penting untuk diimplementasikan agar para korban pelecehan seksual di kampus segera bisa mendapatkan perlindungan. Penelitian ini mencari bagaimana pembingkaian (framing) kedua media ini dalam memberitakan isu Permendikbudristek 30/2021. Dengan analisis framing Zhongdang Pan dan Gerald Kosicki, yang berfokus pada empat struktur (sintaksis, skrip, tematik, retoris), ditemukan bahwa: Republika memprioritaskan pendapat-pendapat yang kontra terhadap dalam menyusun berita. Sementara sebaliknya, Media Indonesia menonjolkan pendapat-pendapat dari pihak yang pro peraturan.Kata kunci: Permendikbudristek 30/2021, Analisis Framing, Republika, Media Indonesia