bluuebunny/crossref_metadata_2025 huggingface dataset:
Shikonin treatment ameliorates Lipopolysaccharides (LPS) induced acute liver failure in mice via regulating the miR-106/MCL1 and miR-34a/SIRT1/TP53 signaling
Authors: Huang Fan , Hai Hua , Gao Buwei
Published: May 2021

Introduction

The treatment with shikonin (SKN) suppresses the expression of miR-106 and miR-34a. Furthermore, SIRT1 and MCL1 are targets of miR-34a and miR-106, respectively. In this study, we treated an animal model of ALF with high dose (1.0 mg/kg) and low dose (0.5 mg/kg) of SKN to investigate its effect on liver functions and signaling pathways of SKN/miR-106/MCL1 and SKN/miR-34a/SIRT1/TP53.

Material and methods

ALF animal model was established and the serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were analyzed to evaluate the effects of different doses of SKN. TUNNEL was performed to assess hepatocyte apoptosis. Luciferase assay, RT-qPCR and Western blot analysis were performed to measure the relationship between miR-106, miR-34a, SIRT1 and MCL1.

Results

In the ALF mice models, the administration of SKN decreased the levels of ALT and AST in a dose-dependent manner, along with a significantly decreased number of apoptotic hepatocytes. And SKN may protect liver during ALF via reducing the level of inflammation. Luciferase assay showed that the co-transfection of wild-type MCL1/SIRT1 and miR-106/miR-34a significantly decreased the luciferase activity of LO2 cells, thus indicating that MCL1 and SIRT1 are identified as targets of miR-106 and miR-34a, respectively, while SIRT1 could act as a regulator of TP53. Moreover, the expression of miR-106, miR-34a and TP53 was decreased over an increasing concentration of SKN, along with the increasing mRNA and protein levels of MCL1 and SIRT1.

Conclusions

In this study, we showed that SKN alleviated ALF in a dose-dependent manner via regulating the signaling pathways of SKN/miR-106/MCL1 and SKN/miR-34a/SIRT1/TP53.
AS CONTRIBUIÇÕES DE PIAGET PARA A EDUCAÇÃO NO MUNDO CONTEMPORÂNEO
Authors: Dias Vagner Neves
Published: May 2021

Jean Piaget formou-se em biologia e com o passar do tempo tornou-se pesquisador em outras áreas, principalmente a educação. Neste trabalho, buscou-se estabelecer uma breve descrição de como este estudioso contribuiu e contribui com a prática docente. Os resultados de suas pesquisas são parâmetros até os dias atuais para que se possam medir a capacidade de assimilação por alunos, bem como definir caminhos para facilitar o aprendizado em todas as idades da infância. Com vasta pesquisa bibliográfica, delimitando-se aos trabalhos que discorreram sobre os seus métodos, vários pensadores e pesquisadores foram citados neste artigo. Mas a unanimidade sobre o valor de seu legado e a contemporaneidade foram de certa forma surpreendentes. Nesta pesquisa, em que metodologia utilizada foi a qualitativa, muitos artigos sobre o trabalho do educador nortearam o texto final. Cognição, epistemologia genética, diferença cultural, etapas de aprendizado na infância, tornam-se muito mais claros e fáceis de serem entendidos ao estudar Piaget e seus seguidores. Assim, conseguiu-se entender não somente a importância do trabalho de Piaget como pesquisador, mas a sua aplicabilidade ainda na atualidade.
Erken Çocukluk Öğretmenlerinin Acil Uzaktan Eğitime İlişkin Görüşleri
Authors: Aykar Ayfer Nur , Yurdakal İbrahim Halil
Published: May 2021

Bu araştırmada erken çocukluk döneminde eğitim veren öğretmenlerin acil uzaktan eğitim sürecine dair düşünceleri; süreç içerisinde karşılaştıkları zorluklar ve bu zorlukları nasıl çözüme kavuşturdukları incelenmiştir. Nitel desenlerden durum çalışmasına uygun olarak yapılandırılan araştırmada katılımcılar amaçlı örnekleme yöntemlerinden ölçüt örnekleme yolu ile belirlenmiştir. Bu bağlamda örneklem seçiminde ölçüt olarak öğretmenlerin erken çocukluk dönem çocuklarıyla çalışıyor olmaları ve acil uzaktan eğitim sürecinde eğitim vermiş olmaları belirlenmiştir. Bu yöntemle belirlenen her biri farklı şehir ve okullarda görev yapan 25 erken çocukluk dönem öğretmeni çalışmanın örneklemini oluşturmaktadır. Yarı yapılandırılmış görüşme formları ile toplanan araştırma verileri içerik analizi ile incelenmiştir. Araştırma sonuçlarına göre öğretmenler özellikle internet erişimi, materyal ve teknolojik araç gereçlere erişim konusunu göz önüne alarak sürecin fırsat eşitliği ilkesine uygun olarak yapılamadığını, aile yaşantılarının eğitime olumsuz şekilde yansıdığı, alt yapı sorunlarının süreci olumsuz etkilediğini, çocukların ekranda uzun süre kalmaları sonucu sürecin özellikle göz sağlığını olumsuz etkilediğini ve özellikle çocukların bazı gelişim dönemlerinde sorunlar yaşadıklarını belirtmektedir. Bunun yanı sıra öğretmenler acil uzaktan eğitim sürecinde aile-öğretmen iletişimin daha etkin olduğunu öne sürmektedir. Araştırma sonuçlarına bakıldığında salgın ve benzeri olumsuz durumların yakın gelecekte tekrar olabileceği göz önüne alınarak özellikle internet erişimi ve alt yapı gibi sorunların giderilmesi gerekliliği bununla birlikte uzaktan eğitim sürecinde öğrencilerin gelişimsel özellikleri dikkate alınarak hibrit tarzı eğitim modellerinin uygulanması gerektiği önerilmektedir.
Sınıf Öğretmeni Adaylarının Gözünden İlkokul Türkçe Derslerinde Somut Olmayan Kültürel Mirasın Aktarımı
Authors: Hakkoymaz Sakine
Published: May 2021

Bu çalışma sınıf öğretmeni adaylarının ilkokul Türkçe Derslerinde Somut Olmayan Kültürel Mirasın Aktarımına yönelik görüşlerinin belirlenmesi amacıyla gerçekleştirilmiştir. Araştırmada nitel araştırma deseni kullanılmıştır. Araştırmanın katılımcılarını 2020-2021 eğitim öğretim yılında bir vakıf üniversitesinin Eğitim Fakültesi Temel Eğitim Bölümü Sınıf Eğitimi Anabilim Dalında 4. sınıfta öğrenim gören 13 öğretmen adayı oluşturmaktadır. Araştırmada veri toplama aracı olarak açık uçlu yedi sorudan oluşan yarı yapılandırılmış görüşme formu kullanılmıştır. Verilerin analizinde, nitel veri analizi tekniklerinden içerik analizi kullanılmış ve veriler yorumlanmıştır. Araştırma sonuçları gelen bir şekilde değerlendirildiğinde sınıf öğretmeni adaylarının somut olmayan kültürel miras kavramını tanıdıkları ve bu mirasın öğretiminin önemli olduğu görüşünü benimsedikleri görülmüştür. Öğretmen adayları somut olmayan kültürel mirasın unsurlarından olan gösteri sanatlarını anlatan metinlere ve milli-manevi değerlere yönelik metinlere Türkçe dersi kitaplarında daha çok yer verilmesi gerektiğinden bahsetmişlerdir. Ayrıca sınıfta ve evde uygulamalı etkinlikler yapılması, kültürel unsurların olduğu yerlere gezi düzenlenmesi ya da bu unsurları anlatan film/belgesellerin sınıfta izletilmesine yönelik önerilerde bulunmuşlardır.
Öğretmen Adaylarının Yazılı Anlatım Hataları
Authors: Arıcı Bayram
Published: May 2021

Bu araştırma Türkçe ve sınıf öğretmeni adaylarının yazım ve noktalamadaki hatalarını tespit edip bunlara çözüm bulmak amacıyla 2019-2020 öğretim yılı bahar döneminde yürtülmüştür. Nitel araştırma yönteminin kullanıldığı araştırmanın çalışma grubunu 80 Türkçe ve sınıf öğretmeni adayı oluşturmuştur. Google formlar aracılığıyla araştırmacı tarafından hazırlanan yazma şablonu öğretmen adaylarına gönderilmiş ve gelen yanıtlar betimsel olarak analiz edilmiştir. Araştırmaya gönüllü olarak katılan öğretmen adaylarının yazılı anlatım hatalarının aşağıdaki başlıklarda toplandığı tespit edilmiştir: 40 sınıf öğretmeni adayının 7058 kelimeden oluşan metinlerdeki hata sayılarının toplamı 797'dir. 40 Türkçe öğretmeni adayının 7023 kelimeden oluşan metinlerdeki hata sayılarının toplamı 826'dır. Türkçe ve sınıf öğretmeni adaylarının yazılı anlatım hataları içerik, ana düşünce, tutarlılık, anlatım bozukluğu, başlık, bilgi yanlışları, dil bilgisi yanlışları, sözcük tekrarları, biçimsel hatalar, imlâ hataları ve noktalama işaretlerinin kullanımıyla ilgili hatalar olarak tespit edilmiştir. Türkçe ve sınıf öğretmenleri bireylerin hayatında en fazla etkiye ve ize sahip olan, temel dil becerilerinin gelişmesine katkıda bulunan kişilerdir. Onların temel dil becerilerinin özellikle yazma becerisinin çok gelişmiş olması önemlidir. Öğretmenlerin yapacakları yazım ve noktalama hataları öğrencilerin yanlışı öğrenip uygulamalarına neden olacağı için öğretmen adaylarının bu alandaki eksikliklerinin tespiti ve giderilmesi konusunda çalışmalar yapılıp en iyi şekilde mesleğe hazır hâle getirilmeleri gerekmektedir. Bu araştırmanın öğretmen adaylarının yazılı anlatımdaki hata ve eksiklerinin farkına vararak eksikliklerini giderip kendilerini geliştirmeye çalışmalarını sağlaması ve öğretmen adaylarına bu bağlamda katkıda bulunması beklenmektedir.
A technique of identifying the contour point to assess the change of abnormal areas on medical imaging
Authors:   Research Institute for Applied Science and Technology, Quy Nhon Universiy, Vietnam, Le Thi Kim Nga , Doan Thi Xuong ,   Library, Quy Nhon University, Vietnam, Doan Thi Thu Cuc ,   Faculty of Information Technology, Quy Nhon University, Vietnam
Published: May 2021

Assessing the growth or reduction of abnormal areas in medical imaging in general and tomography in particular is a greatly concerned and important research issue in recent years in Vietnam. The article presents a technique of identifying contour points of an abnormal area as a basis for later assessment of the development of abnormal area on medical imaging. The technique is based on the analysis of local structures in the vicinity of abnormal area boundaries combined with the use of convolutional neural networks and has been tested and evaluated based on 3D-IRCADb-01 sample data set with liver tumors.
A real-time flooding monitoring and warning system using LoRa technology in Kone and Ha Thanh river basin, Binh Dinh Province
Authors:   Faculty of Engineering and Technology, Quy Nhon university, Vietnam, Nguyen Duc Thien , Tran Van Trung ,   Faculty of Engineering and Technology, Quy Nhon university, Vietnam, Ngo Van Tam , Ho Van Phi
Published: May 2021

In the context of the recent climate change, flooding has been causing serious damages to the human lives and their properties in the world in general, Vietnam in particular, including Binh Dinh province. Therefore, it is pivotal for local governments to build up real-time flooding monitoring and warning systems supported by modern technologies. Addressing to this aim, in this paper, we will study and design a new flooding monitoring and warning system based on a combination of the Long Range (LoRa) teachnology and an open-source platform of Thingsboard. The proposed system allows collecting effectively and sufficiently data from different locations on rivers in a timely manner, thus supporting the early flooding prediction and forecast processes. A testbed of the proposed system is then deployed in the Kone and Ha Thanh river basin, Binh Dinh Province.
Research of object recognition using neural network Inception-v3 model operating on Raspberry Pi B3+
Authors:   Faculty of Engineering and Technology, Quy Nhon university, Vietnam, Nguyen An Toan , Nguyen Ngoc Thien , Nguyen Thanh Truc
Published: May 2021

Image Classification is the most important problem in the field of computer vision. It is very simple and has many practical applications, the image classifier is responsible for assigning a label to the input image from a fixed category group. This article has applied image classification to identify objects by giving the image of the object to be identified, then labeling the image and announcing the label name (object name) through the audio channel. The classification is based on the neural network Inception-v3 model that has been trained on Tensorflow and used Raspberian operating system running on the Raspberry Pi 3 B+ to create a device capable of recognizing objects which compact size and convenient to apply in many fields.
Clustering of periodic orbits of a hyperbolic automorphism on the torus T2
Authors:   Faculty of Mathematics and Statistics, Huynh Minh Hien , Vo Van Nam , Le Tinh , Nguyen Thi Dai Trang
Published: May 2021

This paper deals with clustering of periodic orbits of the hyperbolic toral automorphism induced by matrix A. We prove that Ta satisfies the Axiom A. The clustering of periodic orbits of Ta is ivestigated via the notion of 'p-closeness' of periodic sequences of the respective symbolic dynamical system. We also provide the number of clusters of periodic sequences with given periods in the case of 2-closeness.
Construction and survey of changes in electric arc furnace parameters based on energy conservation model using Pscad software
Authors:   Faculty of Engineering and Technology, Quy Nhon university, Vietnam, Luong Ngoc Toan , Doan Duc Tung
Published: May 2021

Actual analysis showed that the arc furnace current contains many harmonics that adversely affect the power quality. There are many domestic and foreign reports on modeling and assessing the impact of EAF on the grid based on different models. However, EAF's selection of capacity for research and application of power quality improvement devices suitable to the power level has not been mentioned, these models are mainly built on Matlab Simulink software. should be primarily academic. PSCAD is one of the widely used software for electrical system simulation and is used by large companies such as ABB, Korean power corporation Kepco. Building EAF model with PSCAD software will increase the ability to apply simulation results into practice. The objective of the paper is to build an electric arc furnace model based on the energy conservation model with PSCAD software, thereby assessing the change of parameters in the model and the effect of this load on electricity grid during operation.
Determination of voltage distribution on winding of transformer by state variable method
Authors:   Faculty of Engineering and Technology, Quy Nhon university, Vietnam, Doan Thanh Bao , Pham Quoc Vu , Pham Trung Duy ,   Phu My power, Binh Dinh power company, Vietnam,   3Traffic management station - public works, Phu My district, Vietnam
Published: May 2021

A transient overvoltage incident at the transformer terminal generates high-frequency voltage fluctuations that have negative impacts on the transformer. These oscillations may cause damage to the insulation of transformers. These problems are heavy, difficult to restore, and repair. Therefore, overvoltage protection for the transformers is essential. This paper pointed out that the interleaved disk winding has a larger capacitance than that of continuous disk windings. Therefore, the use of interleaved disk winding has the effect of making the voltage distribution on the winding wheels more even and increasing the overvoltage resistance of the transformer. In addition, the value of the voltage at each position of the winding when lightning impulses on the transformer terminal and the voltage distribution on the interleaved disk winding at the time when the lightning impulse has maximum value are also presented in the article. On that basis, the effectiveness of using the interleaved disk winding method in the transformer will be analyzed in detail.
Осы-немки (Hymenoptera: Mutillidae) Белгородской области, Россия
Authors: Лелей Аркадий Степанович , Присный Юрий Александрович
Published: May 2021

Приводен список из десяти зарегистрированных и трех возможных видов ос-немок (сем. Mutillidae), обитающих на территории Белгородской области. Вид Nemka viduata viduata (Pallas, 1773) впервые отмечен в Центральной зоне европейской части России, и подтверждено наличие в этой зоне Ronisia brutia brutia (Petagna, 1787). Для указанных видов, а также для Smicromyrme sicanus (De Stefani 1887), Dasylabris maura sungora (Pallas, 1773) и D. regalis (Fabricius, 1793) Белгородская область является северной границей их распространения в Центральной зоне европейской части России.
Lack of Reform Effect on Exchange Efficiency- Empirical Evidence from Saudi Market Index –
Authors: AlHomaidy Mohammed
Published: May 2021

As development of financial markets has been a growing issue after the financial crisis 2008, this paper has tested efficiency on one of the largest emerging securities markets in the world. It examines lack of reform impact on efficiency of Saudi stock exchange (TASI index) employing random walk hypothesis (RWH) through a battery of parametric and nonparametric tests including autocorrelations, unit root, variance ratio (VR) and Brock, Dechert, and Scheinkman (BDS) test.The study specifically aims to test weak form efficiency before and after massive efforts implemented to reform Saudi exchange. Findings have concluded in a consensus verdict that there is no change observed in TASI index behaviour, and hence it rejected to be a weak-form efficient market. Thus, policy makers and regulators should initiate further reforms; deep regulations and reorganization development to address inefficiency.
COVID-19 Pandemic and Its Implications on Small and Medium Enterprises (SMEs) Operations in Zambia
Authors: Mwaanga Clement , Mulenga James , Lubinda Mary , Siame Moulen , Kaliba-Chishimba Kunda , Mulenga Mulenga Chonzi , Kafula Chilala Sheila
Published: May 2021

The COVID-19 pandemic has slowed down the operations of enterprises of different sizes and types in different ways. The most affected are the SMEs operating in various sectors of the economy. This study sort to investigate the influence of the COVID-19 pandemic on the operations of SMEs in the food and accommodation industry and provide policy recommendations to the government on supportive measures for SMEs. We employed an exploratory methodology with a critical review of available literature, including policy documents, research papers, and relevant literature to the sector Data was collected from four provinces using a survey method, and analysis was conducted through descriptive statistics. The findings indicate that most of the SME's monthly revenues have gone down by more than 50 percent and they are facing challenges such as failing to pay workers, restricted number of customers, and high cost of inputs. Besides, 21 percent of the SMEs reported improved adherence to health guidelines as one of the mitigating factors to minimise the spread of the COVID-19 pandemic. Furthermore, only 4 percent of the SMEs have accessed financial support from Government but their businesses have remained the same. Based on these findings, policy recommendations have been made to help SMEs survive during the crisis.
Slipped Capital Femoral Epiphysis Associated With Vitamin C Deficiency in a 7-year-old Boy
Authors: Nazeer Muhammed , Ravindran Rohith , Katragadda Bharat C. , Muhammed Ehsan N. , Titus Sanuja , Muhammed Mohsin N.
Published: May 2021

Scurvy is rare in the present world and is mostly found in children with abnormal dietary habits and physical and mental disabilities. Scurvy can present in various forms, mimicking several common diseases, thus making the diagnosis difficult. Spontaneous epiphyseal separation is known to occur in scurvy, although rarely reported. The usual locations of these epiphyseal separations are distal femur and proximal humerus. Our case is unique in that scurvy in a seemingly normal child resulted in proximal femur epiphyseal separation which was not reported previously. We report a case of a 7-year-old boy presenting with pain and swelling in multiple joints for 6 months and later inability to walk. Pseudoparalytic frog-leg posture, dietary history of selective eating, and typical radiologic features made us consider a diagnosis of scurvy which was confirmed by a low serum vitamin C level. He developed epiphyseal separation of proximal femur and was treated with percutaneous screw fixation. Vitamin C supplementation resulted in prompt improvement clinically and radiologically.
Reviewer Acknowledgements for Global Journal of Health Science, Vol. 13, No. 5
Authors: Grey Erica
Published: May 2021

Reviewer Acknowledgements for Global Journal of Health Science, Vol. 13, No. 5, 2021.
The Financial Lives and Capabilities of Women Engaged in Sex Work: Can Paradoxical Autonomy Inform Intervention Strategies?
Authors: Yang Lyla S. , Witte Susan S. , Vélez-Grau Carolina , McCrimmon Tara , Terlikbayeva Assel , Primbetova Sholpan , Mergenova Gaukhar , El-Bassel Nabila
Published: May 2021

INTRODUCTION: Despite growing attention to structural approaches to HIV prevention, including economic empowerment interventions for key populations, few studies examine the financial lives of women engaged in sex work (WESW) and even fewer examine the financial lives of those who also use drugs. The purpose of this paper is to examine the financial status, sex work involvement, and individual and structural vulnerabilities of women involved in sex work and drug use in Kazakhstan.

METHODS: We used baseline data from Project Nova, a cluster-randomized controlled trial that tested the efficacy of a combined HIV risk reduction and microfinance intervention for WESW in two cities in Kazakhstan. We collected data on income, savings, debt, sex work, drug use, homelessness, food insecurity, HIV status, attitudes towards safety, and financial knowledge from 400 participants through computer-assisted self-interview techniques. Descriptive statistics were utilized to describe and characterize the sample and aforementioned measures.

RESULTS: Findings illustrate the paradoxical nature of sex work, wherein women may achieve economic independence despite the great adversities they encounter in their daily lives and work. The majority of women (65%) in this study reported being the highest income earner in the household, caring for up to 3 dependents, and demonstrated entrepreneurial characteristics and aspirations for the future. However, many were still living below the poverty line (72.5%), as well as experiencing high levels of homelessness (58%) and food insecurity (89.5%).

CONCLUSION: Study findings underscore the need for better understanding of the existing capabilities of WESW and those who use drugs, including financial autonomy and community supports, that may guide the design of programs that most effectively promote women’s economic well-being and ensure that it is not at the expense of wellness and safety. Designing such programs requires incorporating a social justice lens into social work and public health interventions, including HIV prevention, and attention to the human rights of the most marginalized and highest risk populations, including WESW and those who use drugs.
SCHATTEN-TYPE CLASSES ON SEQUENCE SPACES
Authors: KHALIL R. , SALEH M.
Published: May 2021

Let $H$ be a Hilbert space and $L(H)$ be the bounded linear operators on $H$. For $T\in L(H)$, let
$$||T||_P=\sup\left[\sum_{n=1}^\infty||^p\right]^{1/p},$$
where the supremum is taken over all  orthonormal sequences $(e_n)$. Set $C_p(H)=\{T\in L(H) : ||T||_p<\infty\}$. The object of this paper is to define and study $C_p(X , Y)$ where $X$ and $Y$ are sequences spaces
EXISTENCE OF SOLUTIONS OF SEMILINEAR DIFFERENTIAL EQUATIONS WITH NONLOCAL CONDITIONS IN BANACH SPACES
Authors: BALACHANDR AN K. , CHANDRASEKARAN M.
Published: May 2021

The aim of this paper is to prove the existence and uniquencess of local, strong and global solutions of a nonlocal Cauchy problem for a differential equation. The method of analytic semigroups and the contraction mapping principle arc used to establish the results.
HOLDER CONTINUOUS FUNCTIONS AND THEIR ABEL AND LOGARITHMIC MEANS
Authors: SHARMA SUSHIL , VARMA S. K.
Published: May 2021

Mahapatra and Chandra [8] have obtained the degree of approximation for $f \in H_\alpha(0\le \beta<\alpha\le 1)$ using infinite matrix $A = (a_{nk})$. Mahapatra and Chandra [7] used Euler, Boral and Taylor means. In the present paper we have obtained the analogous results using Abel ($A_\lambda$) and Logarithmic ($L$)-means.
BEST COAPPROXIMATION IN METRIC LINEAR SPACES
Authors: NARANG T. D. , SINGH S. P.
Published: May 2021

In order to obtain some characterizations of real Hilbert spaces among real Banach spaces, a new kind of approximation, called best coapproximation, was introduced in normed linear spaces by C. Franchetti and M. Furi [3] in 1972. Subsequently, the study was pursued in normed linear spaces and Hilbert spaces by H. Berens, L. Hetzelt, T. D. Narang, P. L. Papini, Gectha S. Rao and her students, Ivan Singer and a few others (see, e.g., [1], [4], [7], [9], [13 to 15], and [17 to 20]). In this paper, we discuss best coapproximation in metric linear spaces thereby generalizing some of the results proved in [3], [7], [13], and [18]. The problems considered are those of existence of elements of best coapproximation and their characterization, characteriza­ tions of coproximinal, co-semi-Chebyshev and co-Chebyshev subspaces, and some properties of the best coapproximation map in metric linears space.
Antifibrotics for COVID-19 Related Lung Fibrosis: Agents with Benefits?
Authors: Mishra Mayank , Sindhwani Girish
Published: May 2021

Coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an exponentially spreading pandemic with more than 36 million confirmed cases and over one million deaths worldwide, all within ten months of its first case in Wuhan, China [...]
Comparison of Toxin-Antitoxin Expression among Drug-Susceptible and Drug-Resistant Clinical Isolates of Mycobacterium Tuberculosis
Authors: Kazemian Hossein , Heidari Hamid , Kardan-Yamchi Jalil , Ghafourian Sobhan , Pakzad Iraj , Kouhsari Ebrahim , Valadbeigi Hasan , Sadeghifard Nourkhoda
Published: May 2021

Introduction: Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis (TB), is a significant global public health threat. Besides extensive multidrug resistance, MTB possesses several properties for long-term viability in the host as well as stress adaptation and resistance in harsh conditions. The role of toxin-antitoxin (TA) systems in disseminating and maintaining antimicrobial resistance in bacterial populations has also been demonstrated. This study aimed to evaluate differences in expression of MazEF (a well-known TA system) related genes (mazE3, mazF3, mazE6, and mazF6) amongst drug-susceptible and resistant MTB isolates in Iran. Material and methods: A total of 20 confirmed clinical isolates of MTB including 10 drug-susceptible and 10 drug-resistant (nine MDR, and one XDR) species were included in this study. M. tuberculosis H37Rv was used as the standard strain. RNA extraction, cDNA synthesis, and relative quantitative real-time PCR were performed according to the standard procedures. Results: Our analysis indicated significant enhanced expression of the mazE6 antitoxin gene in drug-susceptible isolates compared to drug-resistant isolates and the standard strain. The expression of the mazF6 toxin gene was also increased in drug-susceptible isolates compared with the standard strain. In drug-resistant isolates, the expression levels of mazF3 and mazF6 genes were significantly higher than that in the susceptible isolates and the standard strain. Conclusions: In this study, there was significant overexpression of mazE6 in drug-susceptible isolates. As well, mazF3 and F6 were overexpressed in drug-resistant isolates when compared with the standard strain. The changes in expression levels of MazEF6 associated genes were greater than that of MazEF3 in both groups of isolates.
Prognostic Significance of Lung Diffusion Capacity and Spirometric Parameters in Relation to Hemodynamic Status in Heart Transplant Candidates
Authors: Mohammadi Somaye , Ramandi Mohammad , Safaei Ali , Mirdamadi Mahsa , Taghavi Sepideh , Amin Ahmad , Naderi Nasim
Published: May 2021

Introduction: Investigations have described a correlation between the severity of heart failure and the severity of pulmonary function abnormalities. In this study, we investigated the association of resting spirometric parameters, lung diffusion for carbon monoxide (DLCO), and the transfer coefficient (KCO) with hemodynamic variables and outcomes in a cohort of heart transplant candidates. Material and methods: Between January 2018 and January 2020, a total of 100 patients with advanced heart failure who were scheduled for right heart catheterization (RHC) as a pre-transplant evaluation measure were enrolled. Spirometry and DLCO were performed in all patients within 24 h of their RHC. All selected patients were followed for a median (IQR) time of 6 (2–12) months. The end points of interest were heart failure-related mortality and a combined event involving HF-related mortality, heart transplantation (HTX), and need for the placement of a left ventricular assist device (LVAD). Results: Among 846 patients scheduled for RHC, a total of 100 patients (25% female) with a mean (SD) age of 38.5 (12.8) were enrolled. There was a significant correlation between FEV1/FVC and CVP (ρ = –0.22, p = 0.02), PCWP (ρ = –0.4, p < 0.001), mPAP (ρ = –0.45, p < 0.001), and PVR (ρ = –0.32, p = 0.001). The cardiac output correlated with DLCO (ρ = 0.3, p = 0.008). Spirometry parameters, DLCO parameters, and hemodynamic parameters did not correlate with the combined event. Among the several variables, only PVR had an independent association with the combined event. Conclusion: Both mechanical and gas diffusion parameters of the lung were not associated with outcomes in the homogeneous group of heart transplant candidates.
Long COVID-19: An Emerging Pandemic in Itself
Authors: Iyengar Karthikeyan , Jain Vijay , Vaishya Raju , Ish Pranav
Published: May 2021

The novel coronavirus SARS-CoV-2 disease is predominantly a respiratory illness that is highly contagious and is spread by droplet transmission. It causes a spectrum of illnesses from a mild sore throat to serious viral pneumonia requiring hospitalisation [...]
Coronavirus Disease 2019 (COVID-19): A Brief Overview of Features and Current Treatment
Authors: Al-Iede Montaha , Badran Eman , Al-lawama Manar , Daher Amirah , Al-Zayadneh Enas , Aleidi Shereen , Khawaldeh Taima , Alqutawneh Basim
Published: May 2021

Since the report of the first cases of pneumonia caused by SARS-CoV-2 in December 2019, COVID-19 has become a pandemic and is globally overwhelming healthcare systems. The symptoms of COVID-19 vary from asymptomatic infection to severe complicated pneumonia with acute respiratory distress syndrome (ARDS) and multiple organ failure leading to death. The estimated case-fatality rate among infected patients in Wuhan, the city where the first case appeared, was 1.4%, with 5.1 times increase in the death rate among those aged above 59 years than those aged 30–59 years. In the absence of a proven effective and licensed treatment, many agents that showed activity against previous coronavirus outbreaks such as SARS and MERS have been used to treat SARS-CoV-2 infection. The SARS-CoV-2 is reported to be 80% homologous with SARS-CoV, and some enzymes are almost 90% homologous. Antiviral drugs are urgently required to reduce case fatality-rate and hospitalizations to relieve the burden on healthcare systems worldwide. Randomized controlled trials are ongoing to assess the efficacy and safety of several treatment regimens.
Femoroacetabular Impingement of the Hip Joint – Literature Review
Authors: Nieszporska Olga , Truszczyńska-Baszak Aleksandra
Published: May 2021

Introduction: In patients with painful hip joint, femoroacetabular impingement is a relatively frequently diagnosed condition. Study aim: The aim of the study was to present the anatomy, biomechanics and pathomechanism of femoroacetabular impingement, surgical diagnostics and treatment, as well as physiotherapeutic procedures, and to provide answers to the following questions: 1. What are the causes of femoroacetabular impingement development and what is its most common form? 2. What are the clinical and imaging diagnosis of femoroacetabular impingement based on? 3. What are the goals of physiotherapeutic treatment in the treatment of patients with postoperative femoroacetabular impingement? Material and method: Current professional literature was analysed based on a review of Internet databases, including Pubmed and Google Scholar. Results: From the abovementioned Internet databases, 30 items from the current profession-al literature on the analysed variables were identified. Conclusions: The reasons for the development of femoroacetabular impingement are com-plex, including developmental disorders of the hip joint or its chronic overload. Its most common form is mixed type. The basic imaging test used is anterior-posterior X-ray, while clinical assessment is based on anterior-posterior impingement test. Physiotherapy should be individually tailored and focused on improving range of motion and muscle strength of the hip joint.
The Barriers to the Success of Cardiopulmonary Resuscitation from the Perspectives of Emergency Medical Services Providers
Authors: Akbari Ayob , Nasiri Ahmad , Mahmodi Mohammad Azim
Published: May 2021

Background: Cardiopulmonary resuscitation (CPR) is an integral part of prehospital emergency care. Addressing the barriers to successful CPR may help improve the quality of CPR in the future. Objectives: The present study aimed to identify the barriers to successful CPR from the perspective of EMS providers. Methods: This cross-sectional analytical study was conducted from May 2015 to Jan 2016. One hundred sixty EMS providers who were employed at EMS affiliated to Birjand University of Medical Sciences (Iran) were selected through simple random sampling. To assess barriers to the success of CPR, data were collected using a researcher-made questionnaire (60 questions) categorized in six subscales. Study data were analyzed by SPSS v.16, descriptive (frequency, mean, and standard deviation), and inferential statistics (t-test and ANOVA). Results: Among the subscales of barriers to successful CPR from the perspective of EMS providers, the EMS structure subscale was the most important (3.06 ± 0.38, out of a 0 - 4 range). In this subscale, public inaccessibility automated external defibrillator (AED) (3.59 ± 0.49) and Lack of telephone-CPR advice by the dispatcher (3.58 ± 0.55) were the most important barriers, respectively. There was a significant difference between the mean score of barriers to successful CPR and educational status, which increased in EMS providers with BS degree (P = 0.003). There was no significant difference between the mean score of barriers to successful CPR compared to the other demographic characteristics of EMS providers (P > 0.05). Conclusions: EMS providers perceived public inaccessibility AED and Lack of telephone-CPR training as the most important barriers to success CPR in prehospital emergency care. Therefore, public access to AED must be emphasized to promote immediate response and improve CPR's outcome in EMS. Moreover, telephone-CPR training by dispatchers should be recommended to help increase the success of CPR.
News from the Field
Authors: Free David
Published: May 2021

MSU Library awards faculty OER grantsLYRASIS, Columbia University Libraries announce e-books partnershipSpringer Nature, UC-Berkeley Library sign new open access book partnershipASERL, DOAJ forge new partnershipLexisNexis introduces Nexis Data LabSpringshare announces new LibCal mapping featuresEx Libris, DataCite launch new integration features
Overdue: Incorporating social justice into the Framework for Information Literacy for Higher Education
Authors: Sweet Christopher
Published: May 2021

The Framework for Information Literacy for Higher Education was adopted by the ACRL Board in 2016. Many librarians, particularly those interested in critical librarianship and critical information literacy, were disappointed that social justice did not explicitly appear anywhere in the Framework. To be fair, multiple elements of the Information has Value frame describe social justice work, specifically the Knowledge Practice: “understand how and why some individuals or groups of individuals may be underrepresented or systematically marginalized within the systems that produce and disseminate information.”
Feasible and flexible: Launching an information and digital literacy badge and certificate program in collaboration with a teaching and learning center
Authors: Peter Samantha , Clement Kristina , Sheridan Shannon , Baribeau Hilary
Published: May 2021

In fall 2019, the University of Wyoming (UW) Libraries launched an information and digital literacy badge and certificate program in partnership with the Ellbogen Center for Teaching and Learning (ECTL), housed in the UW Libraries main branch. ECTL crafts programing and provides support for graduate students, staff, and faculty who teach on our campus by employing instructional designers.The Information and Digital Badge and Certificate Program was created when ECTL redesigned their Teaching and Learning Certificate, and it features many services and resources that UW Libraries already offers (i.e., information literacy instruction and research consultations). This article will detail the redesign of the certificate program, how the current teaching and learning certificate was designed, and conclude with lessons learned from the first year of the program as well as future goals.
Embracing metaliteracy: Metamodern libraries and virtual learning communities
Authors: Hill Valerie J. , Mackey Thomas P.
Published: May 2021

A recent book, Metamodernism and Changing Literacy, by Valerie J. Hill focuses on the intersection of the current philosophical moment by exploring the concept of metamodernism through the lens of metaliteracy. As argued in the book, “Only through metaliteracy can we become digital citizens who seek to acquire, produce and share knowledge in metamodern culture.” In Notes on Metamodernism, Timotheus Vermeulen and Robin van den Akker coin the term metamodernism and argue that it is a discourse based on “recent developments in architecture, art, and film” that oscillates “between a modern enthusiasm and a postmodern irony.” The Notes on Metamodernism webzine features essays on metamodern art and architecture, music and fashion, film and TV, as well as networked culture and politics.
Catalyzing research, building capacity: Research grants and the academic library
Authors: Walde Christine
Published: May 2021

In the days before the pandemic, when I attended and introduced myself as the grants and awards librarian from the University of Victoria (UVic) Libraries at professional events and conferences, my title often evoked quizzical looks. Even now as this unprecedented time continues, as far as I know, I am still the only librarian with this professional designation in Canada, perhaps in all of North America—maybe even the world. Since 2012, I’ve helped UVic Libraries to attract and retain funding, collaborators, allies, and donors, while raising our research profile and demonstrating the value of the 21st-century academic library to university administrators.
The snowball effect: Planning for preservation infrastructure in a small library
Authors: Kortemeier Sarah
Published: May 2021

Small libraries frequently face significant challenges related to funding and staff capacity when attempting to complete large projects and improve infrastructure. With careful planning and a bit of luck, however, it is possible to leverage small successes into much larger accomplishments. The University of Arizona Poetry Center, a special collections library of contemporary poetry within the College of Humanities at the University of Arizona, recently adopted this approach to implement a systematic overhaul of its preservation program.
Designing a flexible outreach program for scholarly communication and copyright services: A modular roadshow for the University of South Florida
Authors: Schmidt LeEtta , Boczar Jason
Published: May 2021

Much the same as many other academic libraries, the University of South Florida (USF) developed scholarly communication and copyright services in response to community demand and to fulfill perceived institutional needs. The services initially established connections through liaison librarians and referral, when faculty patrons intuitively approached the library with a query. Growth of the services was slow. A new method of outreach for copyright and scholarly communication services was needed. The DSS Roadshow, named after the library department Digital Scholarship Services, aimed at providing a menu of modularly configured presentations to faculty and graduate students at the university. Based on two different tracks, scholarly communication or copyright for instruction, the DSS Roadshow was designed to help deliver the services directly to departments around campus.
C&RL Spotlight
Authors: Kaspar Wendi
Published: May 2021

Doing these Spotlights is actually one of the more pleasant aspects of my role as C&RL editor. It is a time to reflect on the works that authors have done and discuss common threads of trending topics. This particular issue is full of a number of compelling articles, so it was actually a little difficult to select a direction to riff on.That said, there are actually two articles that address anxiety, and given that the past year has been nothing but anxiety-inducing, it seems natural to focus on that. In addition, one of most viewed articles in C&RL (it has consistently been in the top three most viewed articles) is “Shame: The Emotional Basis of Library Anxiety” by Erin L. McAfee, which tells me that there is definitely a lot of interest in the topic.
Washington Hotline
Authors: Maher Kevin
Published: May 2021

Gains for higher education included in American Rescue Plan ActOne of the largest spending bills ever approved by Congress—the $1.9 trillion-dollar American Rescue Plan Act (ARPA)—includes unprecedented levels of direct and indirect funding for libraries, including for academic and research libraries.
The Study of the Effectiveness of Coaching Program for Pre-service Teachers to Communicative Listening-Speaking Skills
Authors: Songsiengchai Saifon
Published: May 2021

This study aimed to investigate the effectiveness of the coaching program in communicative listening-speaking skills for pre-service teachers. The subjects for the study were 20 pre-service teachers. They were coached for 18 hours (3 consecutive days). The instruments were coaching plans, a pre-post evaluation to test the pre-service teachers’ knowledge on communicative listening-speaking skills, an evaluation form to assess the pre-service teachers’ performance and a questionnaire on the effectiveness of the coaching program. The data gathered was statistically analyzed by mean and t-test. The findings of this study revealed that: 1) The pre-service teachers’ knowledge and understanding of listening-speaking skills through Communicative language teaching activities were significantly increased at .01 level. 2) The pre-service teachers’ performance in teaching listening-speaking skills got an increased rate at 4.52 level. 3) The quality of the coaching program garnered an effectiveness rate at 4.70 level. 4) The satisfaction questionnaire was at the highest increase rate at the 4.74 level. The coaching program was a viable process. The coach keenly directed the program with a well-thought-out plan about the objectives and goals. The program’s substance and exercises outfitted the pre-service teachers’ information and comprehension of the hypothesis and practice that brought pre-service teachers’ execution in educating listening-speaking aptitudes. At long last, a compelling coach who has a ton of involvement in educator professional advancement can break the ice between the coach and pre-service teachers to accomplish informative Listening-Speaking educating abilities during teaching practicum before the pre-service teachers can genuinely be professional teachers in the future.
The Nonverbal means of Communication in Mongolian using the Word “Tolgoi (‘Head’ in English)”
Authors: Onon Tsulbaatar , Azzaya Badamjav , Otgonsuren Tseden
Published: May 2021

One of the most important activities in which we engage, is communication. It plays a vital role in our lifestyles, careers and demeanors. This paper, which can be considered a continuation of early observations and then a study, touches upon the types of nonverbal means of communication in the modern Mongolian language, based on examples that have used the word “tolgoi (‘head’ in English)” and cited modern Mongolian literature. In modern Mongolia, nonverbal means of communication have their own special types, forms and grammar, which all use real words and expressions related to Mongolian culture, customs and lifestyle. For this research paper, 23 nonverbal means of communication using the word tolgoi were recorded, and most of them expressed ignorance, sadness or regret, which indicated a negative attitude.
Syntax of Standard English and Bangla: A Bilingual Study of Simple Declarative Sentences
Authors: Akan Md. Faruquzzaman
Published: May 2021

This research paper explores much of the basic and background knowledge of English and Bangla sentence patterns or structures as well as tries to compare and contrast between these two very languages, English and Bangla at the sentential levels. As it is known the concept of basic sentence structures is necessary for classroom teaching and learning to perceive the subtleties of language at the highest unit of grammar, this study is expected to facilitate the understanding of bilingual relationships between them (may be as a native or a foreign language) for researchers, teachers, learners and/or speakers of both the languages. The ideas drawn from the findings in this paper will also help one in the field of translating amid these two languages which is pedagogically very significant as well. For a few dissimilarities, we often notice greatly faulty grammatical constructions both in English and Bangla, when learners or users shift from one to another. So, this study of the two types of sentence patterns along with their components will be of considerable use to many, specially to those who teach, learn or use these languages.
Study on the Risk Assessment of Spontaneous Ignition and of Perilla Oil Cakes Associated Activation Energy
Authors: Byun Sung-Ho , Choi Yu-Jung , Jeong Jae-Hoon , Choi Jae-Wook
Published: May 2021

Perilla oil cakes are the residues of oil pressing processes, and used as fertilizers, feedstuff, food, etc. However, according to recent reports, perilla oil cakes often ignite spontaneously due to scorching heat, particularly in rice mills, general mills, and oil mills where large amounts of perilla oil cakes are stored. Thus, in this study, we attempted to elucidate the risk of spontaneous ignition of perilla oil cakes. For this purpose, thermogravimetry/differential thermal analysis (TG-DTA) was performed to identify thermal properties like weight reduction and heat generation, and spontaneous ignition was conducted for sample vessels of different thicknesses. The results showed that the ignition temperature of perilla oil cakes was 115 ℃ for the small (20 cm × 20 cm × 3 cm) vessel. The apparent activation energy associated with the critical ignition temperature was 60.74 kJ/mol. The ignition delay time and the time to reach maximum temperature were both found to increase with increasing vessel thickness. It was concluded that proper protection against heat must be in place because fire risk increases and spontaneous ignition can occur when large amounts of perilla oil cakes are accumulated.
Risk Assessment of a MLCC Plant through Fire and Evacuation Simulations
Authors: Son Kwang-Tae , Son Jong-Yeong , Bae Young-Hoon , Choi Jun-Ho
Published: May 2021

In this paper, fire and evacuation simulations are conducted for the Multi-Layer Ceramic Capacitor (MLCC) factory clean room, and a plan to improve performance standards in the field of performance-based design simulation is suggested. First of all, fire and evacuation risk factors in the clean room were derived through fire accidents and previous research. And fire and evacuation simulations were performed using the derived risk factors as variables. As a result of the simulations, it was found that 'air conditioning equipment', 'working capacity', 'door setting method' and 'life safety evaluation method' have an influence on the life safety evaluation. Finally, a plan to improve the standards for fire and evacuation simulation was suggested to reflect the factors influencing the life safety evaluation.