bluuebunny/crossref_metadata_2025 huggingface dataset:
Role-Playing Learning Method in Shaping Commendable Morals of Students in Islamic Education Subjects
Authors: Huda Ali Anhar Syi’bul , Syahidin Syahidin , Nurhuda Abid
Published: November 2023

This study aims to determine the implementation of the role-playing learning method in PAI subjects in forming students' commendable morals. The research was conducted using a qualitative approach with the literature study method, collecting data through the latest and old literature (journals, books, proceedings) as primary data and sources from the internet as secondary data, the results of which were then described descriptively. The results obtained show that the role-playing learning model helps and is effective in developing students' commendable characteristics such as honesty, discipline, and good manners toward learning. This can happen because students gain direct experience by playing one character or another. What they experienced internalized within themselves so that there was a good change from before. Then based on the literature review it was also found that the role-playing learning method could be implemented in PAI subjects with the teaching material of the Story of the Prophet Abraham. Through the story of Prophet Ibrahim, students gain experience on how to respect their parents, act well, be honest, obey, and trust. The research carried out can contribute to the development of learning methods for parties involved in education, with a variety of learning methods applied that can provide meaningful learning by both teachers and students.
Abstrak: Penelitian ini bertujuan untuk mengetahui implementasi dari metode pembelajaran role playing pada mata pelajaran PAI dalam membentuk akhlak terpuji siswa. Penelitian dilakukan menggunakan pendekatan kualitatif dengan metode studi pustaka, pengumpulan data melalui literatur-literatur terbaru dan lama (jurnal, buku, prosiding) sebagai data primer dan sumber dari internet sebagai data sekunder yang kemudian hasilnya dijabarkan secara desriptif. Hasil yang didapatkan bahwa model pembelajaran role playing membantu dan efektif dalam menumbuhkembangkan karakter terpuji siswa seperti kejujuran, kedisplinan, dan adab yang baik terhadap berguru. Hal demikian dapat terjadi karena siswa mendapatkan pengalamannya secara langsung dengan memerankan satu tokoh atau peran lainnya. Dari apa yang mereka alami menginternalisasi dalam diri sehingga adanya perubahan yang baik dari sebelumnya. Kemudian berdasarkan telaah literatur juga didapati bahwa metode pembelajaran role playing dapat dilaksanakan pada mata pelajaran PAI dengan materi ajar Kisah Nabi Ibrahim. Melalui kisah nabi Ibrahim siswa mendapatkan pengalaman bagaimana cara menghormati orangtua, berlaku baik, jujur, taat, dan tawakal. Penelitian yang dilakukan dapat menjadi sumbangsih bagi pengembangan metode pembelajaran bagi pihak-pihak yang terlibat dalam dunia pendidikan, dengan adanya variasi metode belajar yang diterapkan mampu memberikan kebermaknaan belajar baik oleh guru maupun siswa.
Building a Resilient Global Economy
Authors: Purohit Brijesh C.
Published: November 2023

In this paper we discuss the concept of economic resilience which is the ability of the economy to respond to a economic shock and recover at the fastest pace. We take into consideration the survey reports of RBI. The six surveys recently published by RBI depicts that India is becoming more resilient economy. The concept discussed only at the country level by earlier international studies although indicate India’s relative international ranking as 65. We develop a state level index by appropriate modification of the concept of economic resilience to the state level context. Thus, our state level resilience index depicts Maharashtra and Jharkhand as highest and lowest resilient States respectively. However, our state level indices are in the nascent State and future research may be more useful to further develop it for more confident application in analytical studies.
Literature Review: The Influence of Motivation, Work Discipline, Job Satisfaction, and Employee Loyalty on Employee Performance
Authors: Nurzanah Eka , Damaiyanti Alia
Published: November 2023

The purpose of this article is to analyze the impact of motivation, work discipline, job satisfaction, and loyalty on employee performance based on five articles. This narrative literature review aims to identify and summarize previously published articles without critique of the reviewed articles. The type of research used in these five articles is quantitative. Employees are individuals capable of performing work, making them critically important as human resources for companies to support the achievement of set targets. This study has found a mutually positive relationship between variables. Among them, motivation affects employee performance, work discipline affects employee performance, job satisfaction affects employee performance, and work loyalty affects employee performance. This research has produced several reviews from five articles that have provided scientific decisions. The contribution of this research is expected to provide ease for other researchers who will develop their scientific work with similar themes in the future.
Abstrak: Tujuan penulisan artikel ini adalah untuk menganalisis pengaruh motivasi, disiplin kerja, kepuasan kerja, dan loyalitas terhadap kinerja karyawan terhadap lima artikel. Narrative literature review ini bertujuan untuk mengidentifikasi dan meringkas artikel yang telah diterbitkan sebelumnya tanpa ada kritik untuk artikel yang direview. Jenis penelitian yang digunakan dalam 5 artikel ini adalah penelitian kuantitatif. Karyawan merupakan orang yang mampu melakukan pekerjaan, sehingga karyawan sangat penting sebagai sumber daya manusia bagi perusahaan untuk menunjang proses tercapainya target yang sudah ada.penelitian ini telah menemukan adanya hubungan yang saling berpengaruh positif antara variabel. Diantaranya motivasi berpengaruh kinerja karyawan, disiplin kerja berpengaruh terhadap kinerja karyawan, kepuasan kerja berpengaruh terhadap kinerja karyawan, dan loyalitas kerja berpengaruh terhadap kinerja karyawan. Penelitian ini telah menghasilkan beberapa kajian dari 5 artikel yang telah memberikan keputusan secara ilmiah. Kontribusi penelitian ini diharapkan dapat memberikan kemudahan bagi peneliti lain yang akan mengembangkan karya ilmiahnya dengan tema yang serupa dikemudian hari.
Severity of Post Obturation Pain in Single Versus Multiple Sittings Endodontic Treatment Using Rotary Nickle Titanium Instruments
Authors: Noor Nouman , Azhar Rahima , Sartaj Rafia , Mujtaba Hasan , Humayoun Sadaf , Javaid Muhammad Mohsin , Muhammad Athar
Published: November 2023

Objective: To evaluate the significant difference in the incidence and severity of post-obturation pain following single-visit and multiple-visit root canal treatments.
Methodology: This study was conducted in the Operative Dentistry Department of Rawal Dental Hospital in Islamabad. A total of 156 patients were randomly assigned to two groups, with 78 participants in each group. Prior to treatment, all participants were asked to mark a horizontal scale to indicate the intensity of their pain. After 24 hours of treatment, participants were questioned about their pain using a Visual-Analogue Scale. SPSS- 20 was used & Independent T-test was done for an analysis. P<0.05 was well-thought-out as statistically significant.
Results: The study comprised 93 male participants (59.6%) and 63 female participants (40%). Among the treated teeth, 80 (51%) were anterior teeth, and 76 (48%) were posterior teeth. The mean Visual-Analogue Scale (VAS) and standard deviation (SD) for Group 1 before treatment were 9.12 and 1.98, respectively, while for Group 2, they were 8.76 and 1.03, respectively. After 24 hours post-operatively, the mean VAS and S.D for Group 1 were 5.58 and 1.92, and for Group 2, they were 4.86 and 1.18, respectively. An independent sample t-test revealed a statistically insignificant variation in pre- and post-operative pain levels in both groups.
Conclusion: The incidence of pain was lower in the multi-visit group compared to the single-visit group, but this difference was not statistically significant.
Limites da ética discursiva a partir da ética da produção
Authors: DOMBROSKI MARCOS ANTONIO
Published: November 2023

Neste texto, abordam-se os desafios da Ética do Discurso no contexto do modelo de produção capitalista, seguindo a perspectiva da Ética da Produção de Sírio Lopez Velasco em quatro estágios. Examina-se a falta de consenso argumentativo nas empresas capitalistas, onde os proletários são obrigados a obedecer aos capitalistas. Analisa-se a norma fundamental da Ética do Discurso no contexto do capitalismo global, com Velasco discordando de Apel sobre a satisfação das necessidades humanas pelas diferentes classes sociais. O terceiro ponto considera o capitalismo como um sistema mundial e os princípios reguladores de longo prazo da Ética do Discurso. Velasco questiona a sobrevivência da humanidade no atual modelo de produção. Por fim, explora-se a influência do sistema na comunidade científica. Em resumo, Velasco argumenta que a Ética do Discurso não pode funcionar no capitalismo devido às condições de trabalho, desigualdades e à ausência de uma verdadeira comunidade de comunicação.
IMPLEMENTASI MANAJEMEN KONFLIK DALAM UPAYA PENCEGAHAN DAN PENANGGULANGAN TINDAK KEKERASAN DI SMPN 59 KOTA BANDUNG
Authors: Suherlan Pramesti Salma Ihsandina , Hidayat Wahyu
Published: November 2023

Menurut Kementerian Pemberdayaan Perempuan dan Perlindungan Anak (KemenPPPA) tercatat ada 6.139 jumlah kasus kekerasan yang terjadi di lingkungan rumah, sekolah dan masyarakat. Tujuan penelitian ini adalah untuk mengetahui implementasi manajemen konflik dalam upaya pencegahan dan penanggulangan tindak kekerasan di lingkungan satuan pendidikan. Subjek penelitian ini adalah guru bimbingan konseling di SMPN 59 Kota Bandung. Metode penelitian ini menggunakan pendekatan kualitatif studi lapangan dengan pengumpulan data melalui wawancara, observasi, dan dokumentasi. Hasil penelitian menunjukan kekerasan terjadi hanya berbentuk kekerasan verbal yang disebabkan oleh candaan. Upaya pencegahan dilakukan dengan mengikuti pelatihan, deklarasi Roots Day dan membentuk tim agen perubahan di setiap kelas. Prosedur penanggulangan melalui beberapa tahap yaitu guru mata pelajaran, wali kelas, guru bimbingan konseling, dan kesiswaan. Dengan demikian, SMPN 59 mampu mengimplementasikan manajemen konflik dalam upaya pencegahan dan penanggulangan tindak kekerasan di lingkungan satuan pendidikan
Organo-mineral sorbents and their effect on the rate of carbon dioxide emission from the surface of agro dark gray soil
Authors:   Kursk state university, Kuznetsova Ekaterina , Nevedrov Nikolay
Published: November 2023

The article presents data on the influence of sorbents on the dynamics of microbial respiration of agro dark gray soil. The rate of CO2 emission from soils treated with Keloway clay and sorbent based on sapropel and lime agrotem-gray soils increased by 72.8 83.5% relative to soils without sorbents. Keywords: SORBENT, SAPROPEL, LIME, HEAVY METALS, AGRO DARK GRAY SOIL, MICROBIOLOGICAL ACTIVITY
Fostering Financial Inclusion and Education Access in the Global South: Collaborative Stratagem
Authors: Owuondo Joseph
Published: November 2023

This investigation delves into the intricate challenges surrounding financial inclusion and convenient access to high-quality education within the Global South, encompassing regions such as Latin America, Asia, Africa, and Oceania. The study underscores the pressing imperative for concerted action to ameliorate the dire state of the education system. A considerable segment of the populace grapples with limited access to superior education due to financial constraints, inadequately trained educators, substandard learning environments, and the exclusion of children with varying abilities. These barriers impede not only individual advancement but also stymie collective socio-economic progress, perpetuating disparities in society. The study accentuates the pivotal role played by partnerships, advocacy initiatives, and innovative financial paradigms in surmounting these challenges, drawing upon an extensive corpus of research and empirical data. Emphasizing the necessity of forging collaborations among commercial enterprises, non-profit entities, and educational institutions, it aims to bridge the resource and infrastructure gaps in education. Propelled by advocacy campaigns, policymakers, communities, and diverse stakeholders can be effectively convinced of the profound value of financial education and literacy. A significant obstruction scrutinized in this study is the financial aspect, constituting a formidable barrier to accessing high-caliber education across the Global South. Financial constraints manifest in elevated dropout rates and diminished educational attainments, exacerbating extant societal disparities. Innovative financial strategies, such as grants, scholarships, microloans, and digital payment alternatives, serve as potent instruments for bolstering accessibility and affordability of higher education. Concluding this study is an exhaustive compendium of recommendations to redress these pressing challenges. These recommendations encompass fortifying partnerships, advocating for enhanced financial literacy, implementing cost-effective measures, augmenting the availability of scholarships and grants, and underscore the vital importance of international cooperation. The research underscores the criticality of funding teacher training programs and bolstering educational infrastructure as indispensable components within a holistic strategy aimed at enhancing education within the Global South.
FATORES DE RISCO PARA DIABETES GESTACIONAL: UMA REVISÃO DE LITERATURA
Authors: Andrade Manuela Marinho de , Souza Thifisson Ribeiro de , Faria Catarina Pioli Lamêgo de , Silva Victoria Soares de Farias , Costa Letícia Sousa Amancio da
Published: November 2023

O diabetes mellitus gestacional (DMG) pode ser definido como uma intolerância a carboidratos com gravidade variável. Ocorre devido ao aumento da resistência insulínica, geralmente ocasionada pelos hormônios envolvidos na gestação. A doença tem início durante a gravidez, logo, seu diagnóstico e tratamento precoce é inevitável para a redução de complicações materno-fetais. O DMG é a principal complicação metabólica durante a gravidez. Sua prevalência pode chegar a 25% nas gestantes dependendo do local de estudo, tendo índices mais elevados entre mulheres que vivem no Oriente Médio e no Norte da África. No Brasil, estima-se que esses dados podem chegar a 18%, mostrando que o tema possui grande relevância em âmbito internacional e nacional. Tendo em vista a grande importância deste tema para a saúde pública em geral, esta revisão narrativa de literatura reuniu artigos das principais bases de dados objetivando explorar na literatura selecionada possíveis fatores de risco predisponentes ao DMG, destacando os de maior importância para o surgimento da doença. Concluiu-se que os principais fatores de risco para o desenvolvimento de diabetes durante a gestação são o sobrepeso e a idade da gestante (geralmente acima dos 35 anos de idade).
Opinion: A critical evaluation of the evidence for aerosol invigoration of deep convection
Authors: Varble Adam C. , Igel Adele L. , Morrison Hugh , Grabowski Wojciech W. , Lebo Zachary J.
Published: November 2023

Abstract. Deep convective updraft invigoration via indirect effects of increased aerosol number concentration on cloud microphysics is frequently cited as a driver of correlations between aerosol and deep convection properties. Here, we critically evaluate the theoretical, modeling, and observational evidence for warm- and cold-phase invigoration pathways. Though warm-phase invigoration is plausible and theoretically supported via lowering of the supersaturation with increased cloud droplet concentration in polluted conditions, the significance of this effect depends on substantial supersaturation changes in real-world convective clouds that have not been observed. Much of the theoretical support for cold-phase invigoration depends on unrealistic assumptions of instantaneous freezing and unloading of condensate in growing, isolated updrafts. When applying more realistic assumptions, impacts on buoyancy from enhanced latent heating via fusion in polluted conditions are largely canceled by greater condensate loading. Many foundational observational studies supporting invigoration have several fundamental methodological flaws that render their findings incorrect or highly questionable. Thus, much of the evidence for invigoration has come from numerical modeling, but different models and setups have produced a vast range of results. Furthermore, modeled aerosol impacts on deep convection are rarely tested for robustness, and microphysical biases relative to observations persist, rendering many results unreliable for application to the real world. Without clear theoretical, modeling, or observational support, and given that enervation rather than invigoration may occur for some deep convective regimes and environments, it is entirely possible that the overall impact of cold-phase invigoration is negligible. Substantial mesoscale variability of dominant thermodynamic controls on convective updraft strength coupled with substantial updraft and aerosol variability in any given event are poorly quantified by observations and present further challenges to isolating aerosol effects. Observational isolation and quantification of convective invigoration by aerosols is also complicated by limitations of available cloud condensation nuclei and updraft speed proxies, aerosol correlations with meteorological conditions, and cloud impacts on aerosols. Furthermore, many cloud processes, such as entrainment and condensate fallout, modulate updraft strength and aerosol–cloud interactions, varying with cloud life cycle and organization, but these processes remain poorly characterized. Considering these challenges, recommendations for future observational and modeling research related to aerosol invigoration of deep convection are provided.
Mapping the Future Afforestation Distribution of China Constrained by National Afforestation Plan and Climate Change
Authors: Song Shuaifeng , Zhang Xuezhen , Yan Xiaodong
Published: November 2023

Abstract. Afforestation has been considered a critical nature-based solution to mitigate global warming. China has announced an ambitious afforestation plan covering an area of 73.78×104 km2 from 2020 to 2050. However, it is unclear where it will be suitable for afforestation under future climate change. Here, we carried out a finer resolution (25 by 25 km) of climate change dynamic downscaling for China using the WRF model nested with bias-corrected MPI–ESM1–2–HR model; then, using the Holdridge life zone model forced by the WRF model output, we mapped the climatological suitability for forest in China. The results showed that the potential forestation domain (PFD) at present (1995–2014) approximated 500.75×104 km2, and it would increase to 518.25×104 km2, by about 3.49 %, to the period of 2041–2060 under the SSP2–4.5 scenario. Considering the expansion of the future PFD caused by climate change, the afforestation area for each province was allocated into grid cells following the climatological suitability for the forest. The newly afforestation grid cells would occur around and to the east of the Hu Line. Due to afforestation, the land cover would be modified. The conversion of grasslands to deciduous broadleaf forests in northern China covered most area, accounting for 41 % of the newly afforestation area. The grid cell-resolved afforestation dataset was consistent with the provincial afforestation plan and the future climatological forest suitability. It would be valuable for investigating the impacts of future afforestation on various aspects, including the carbon budget, ecosystem services, water resources, and surface climate.
A machine learning approach to the geomorphometric detection of ribbed moraines in Norway
Authors: Barnes Thomas James , Schuler Thomas Vikhamar , Filhol Simon , Lilleøren Karianne Staalesen
Published: November 2023

Abstract. Machine learning is a powerful yet underutilised tool in geomorphology, commonly used for image–based pattern recognition. Analysing new high–resolution (1–10 m) elevation datasets, we investigate its usefulness for detecting discrete geomorphological features. This study develops a machine learning–based method for identifying ribbed moraines in digital elevation data and progresses to test its performance versus time consuming, manual methods. Ribbed moraines share geomorphometric characteristics with other glacial landforms, hence represent a valuable test of our new methodology in terms of differentiating between similar features, and wider for detection of landforms with similar characteristics. Furthermore, mapping ribbed moraines may provide valuable indications of their origin, a topic of debate within glacial geomorphology. To automatically detect ribbed moraines, we extract simple morphometrics from high–resolution digital elevation model data and mask regions where ribbed moraines are unlikely to form. We then test several machine learning algorithms before examining the best performer (K–means clustering) on three study areas in Norway of 15 km2. Our results demonstrate balanced accuracy of 65–75 % when validating versus ground–truth. The performance depends on the availability of high–resolution elevation data in Norway, needed to resolve the spatial scale of the target (10–100 m). We find the method effective at detecting both fields of ribbed moraines as well as individual ribbed moraines. We propose pathways for future implementation of this method on a large–scale and for increasing the detail of information gained about detected landforms. In conclusion, we demonstrate K–means clustering as a promising method for detecting ribbed moraines, with great potential to reduce the time needed to produce landform maps.
Soot aerosol from commercial aviation engines are poor ice nucleating particles at cirrus cloud temperatures
Authors: Testa Baptiste , Durdina Lukas , Alpert Peter A. , Mahrt Fabian , Dreimol Christopher H. , Edebeli Jacinta , Spirig Curdin , Decker Zachary C. J. , Anet Julien , Kanji Zamin A.
Published: November 2023

Abstract. Ice nucleating particles catalyse ice formation in clouds, affecting climate through radiative forcing from aerosol-cloud interactions. Aviation directly emits particles into the upper troposphere where ice formation conditions are favourable. Previous studies have used proxies of aviation soot to estimate their ice nucleation activity, however the investigations with commercial aircraft soot from modern in-use aircraft engine have not been quantified. In this work, we sample aviation soot particles at ground level from different commercial aircraft engines to test their ice nucleation ability at temperatures ≤ 228 K, as a function of engine thrust and soot particle size. Additionally soot particles were catalytically stripped to reveal the impact of mixing state on their ice nucleation ability. Particle physical and chemical properties were further characterised and related to the ice nucleation properties. The results show that aviation soot nucleates ice at or above relative humidity conditions required for homogeneous freezing of solution droplets (RHhom).We attribute this to a mesopore paucity inhibiting pore condensation and the sulfur content which suppresses freezing. Only large soot aggregates (400 nm) emitted under 30–100 % thrust conditions for a subset of engines (2/10) nucleate ice via pore condensation and freezing. For those specific engines, the presence of hydrophilic chemical groups facilitates the nucleation. Aviation soot emitted at thrust ≥100 % (sea level thrust) nucleates ice at or above RHhom. Overall our results suggest that aviation soot will not contribute to natural cirrus formation and can be used in models to update impacts of soot-cirrus clouds.
A coupled hydrological and hydrodynamic modelling approach for estimating rainfall thresholds of debris-flow occurrence
Authors: Wei Zhen Lei , Shang Yue Quan , Liang Qiu Hua , Xia Xi Lin
Published: November 2023

Abstract. Rainfall-induced hydrological processes and surface water flow hydrodynamics may play a key role in initiating debris flows. In this study, a new framework based on an integrated hydrological and hydrodynamic model is proposed to estimate the Intensity-Duration (I-D) rainfall thresholds that trigger debris flows. In the new framework, intensity-duration-frequency (IDF) analysis is carried out to generate design rainfall to drive the integrated models to calculate grid-based hydrodynamic indices (i.e. unit-width discharge). The hydrodynamic indices are subsequently compared with hydrodynamic thresholds to indicate the occurrence of debris flows and derive rainfall thresholds through the introduction of a zone threshold. The capability of the new framework in predicting the occurrence of debris flows is verified and confirmed by application to a small catchment in Zhejiang Province, China, where observed hydrological data are available. Compared with the traditional statistical approaches to derive Intensity-Duration (I-D) thresholds, the current physically-based framework can effectively take into account the hydrological processes controlled by meteorological conditions and spatial topographic properties, making it more suitable for application in ungauged catchments where historical debris flow data is lacking.
Antichistica e razzismo nel dibattito culturale statunitense. Una intervista ad Alice Borgna
Authors: Franchini Alberto
Published: November 2023

In the interview, Alice Borgna addressed the issue, particularly controversial in the U.S. today, of the relationship between classical culture and multicultural societies that claim other models of the past. In light of the debate sparked by Padilla Peralta’s statements about racism inherent in the study of the Classics, Borgna reflects on the relationship between minorities and culture, on the celebration of the classical world in a profoundly changed world where a significant portion of the population no longer recognizes itself in that past.
La dinamica dei confini orientali dell’Italia romana: fonti antiche e riletture moderne
Authors: Zaccaria Claudio
Published: November 2023

The state of knowledge and the still open problems concerning the borders of Roman Italy are presented, pointing out that their evolution is known in broad outline, while some details concerning the positioning of the borders and the absolute chronology remain unresolved. In addition, some examples are presented of how the borders of Roman times, whether real (such as the Augustan border at Arsia) or presumed (such as the praetentura Alpium or the claustra Alpium Iuliarum) have been evoked on several occasions during the negotiations to define the borders of modern states.
Prace ks. prałata Józefa Gottschalka o św. Jadwidze Śląskiej
Authors: Urban Wincenty
Published: November 2023

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Cytolytic hypertransaminasemia and cholestasis in patients diagnosed with infectious mononucleosis by the Epstein-Barr virus: Review of cases between 2016 and 2023
Authors:   Lesaka Health Center (Navarra), Koskontako kalea 6, Lesaka 31770, Navarra, Spain, Dieguez Ion Koldobika Iribar
Published: November 2023

Infectious mononucleosis can lead to self-limited liver disorders. The objective is to verify if our patients diagnosed with infectious mononucleosis present these alterations, and their characteristics, in addition to providing a reference that allows a safer management, and a documentary base
Body stalk anomaly
Authors:   Department of Pediatric Surgery, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo,113-8519, Japan, Okamoto Kentaro
Published: November 2023

A 29-year-old pregnant woman was referred to our hospital at the gestational age of 15 weeks. The umbilical cord hernia was pointed out during a fetal echocardiogram at the previous obstetrician’s office, and the patient was referred to our obstetrician
Cholesteatoma of petrous bone: Auditory improvement with surgical treatment novel application of the posterior retrosigmoid approach
Authors:   Department of Neurosurgery, Hospital Clinic San Carlos, Calle del Profesor Martín Lagos, s/n, 28040 Madrid, Spain, Arevalo-Saenz Alejandra
Published: November 2023

Introduction: Petrous Bone Cholesteatomas (PBCs) are epidermoid cysts, which have developed in the petrous portion of the temporal bone and may be congenital or acquired.
Homeostasis of Circadian Rhythm and Therapeutic Approaches to Manage its Related-Disorders: The Case of Medicinal Mushrooms Rich in Melatonin
Authors:   Faculty of Health and Rehabilitation Sciences, Metropolitan College, 41005, Larissa, Greece., Siafis Sofia K Georgiou
Published: November 2023

Circadian rhythm consists of complicated molecular mechanisms to orchestrate environmental stimuli to intrinsic molecular clocks. However, circadian rhythm is frequently deregulated in modern society by both extrinsic and biological factors leading to Circadian Rhythm Sleep Disorders
Emmanuel de Martonne's glacial geomorphology research in Parâng Massif (the Southern Carpathians)
Authors:   University of Craiova, Geography Department, 13 A.I. Cuza Street, 410087, Craiova, Dolj, Romania, MARINESCU Emil , MARINESCU Sidonia ,   University of Craiova, University Library, 13 A.I. Cuza Street, 410087, Craiova, Dolj, Romania
Published: November 2023

We are publishing this article in 2023, the year when the 150th anniversary of the birth of the French geographer is celebrated, the article being a tribute to Emmanuel de Martonne's work in Romania, especially for his contribution to the research of the Transylvanian Alps (the Southern Carpathians). Of the two doctoral theses that the French geographer elaborated on the territory of Romania, the last one, defended in 1905 and published in 1907 at the Sorbonne University in Paris, was dedicated to the geomorphological evolution of the Transylvanian Alps (the Southern Carpathians). Of the 14 field campaigns that Emmanuel de Martonne carried out in Romania, eight were carried out in the Southern Carpathians (Banat Massif, Transylvanian Massif) and in the neighboring regions closely related in their paleogeographical evolution to the Transylvanian Alps (the Subcarpathian area of Oltenia, the Subcarpathian area of Muntenia, and Mehedinți Plateau). For the French geographer, the transverse valleys of the Southern Carpathians were examples indicating the extensive tectonic movements that affected the territory of Romania in the Paleogene and Neogene. Glacial influences and relief forms in the high part of the Southern Carpathians became the main concern of the French geographer for at least a decade of research in Romania. More obviously, in some parts of the Southern Carpathians, the action of glaciation cut out specific shapes within the platform of the high peaks (Borăscu planation platform). In the research in Parâng Mountains, Emmanuel de Martonne aimed to identify some key evidence of glaciation: glacial cirques, lakes, valleys, thresholds, glacial grooves, glaciated knobs, and moraines. Above all, the French geographer believed that the general topography of the valleys and cirques is the fundamental element that certifies glaciation and the presence of lateral cirques justifies the succession of glacial periods.
The influence of topography on the subsidence processes of loess-like deposits from Sălcuța Plain (South-Western Romania)
Authors:   University of Craiova, Geography Department, 13 A.I. Cuza Street, 200585, Craiova, Dolj, Romania, TĂNASE George , BOENGIU Sandu ,   University of Craiova, Geography Department, 13 A.I. Cuza Street, 200585, Craiova, Dolj, Romania, MITITELU-IONUȘ Oana ,   University of Craiova, Geography Department, 13 A.I. Cuza Street, 200585, Craiova, Dolj, Romania, SIMULESCU Daniel ,   National Agency for Protected Natural Areas, Dolj Territorial Service, Calea Unirii, no. 147, 200330, Craiova, Dolj
Published: November 2023

This paper aims to establish the role of the local topography of Sălcuța Plain (subdivision of the Oltenia Plain) in the subsidence process of loess-like deposits. The relevant features of the topography, especially the slope, were generated using SAGA GIS v.7.8.0 and QGIS v.3.22 software based on an altimetric terrain model. The results obtained highlight the fact that 303 microdepressions were formed following the chemical and mechanical subsidence of the loess deposits. The most important characteristic, which conditions the genesis of the subsidence process and implicitly the formation of microdepressions, is the slope; in this case, the subsidence process occurs in areas where the slope has values lower than 2 degrees. The research advanced by generating the Topographic Wetness Index (TWI) in order to identify areas with moisture excess, the moistening of loess-like deposits being one of the basic conditions in the genesis of the subsidence process. The highest values of the Topographic Wetness Index (TWI), over 10, were recorded in the areas with microdepressions.
Mapping the dimension of soil sealing in Craiova city (Romania) using GIS and Remote Sensing techniques
Authors:   University of Craiova, Geography Department, 13 A.I. Cuza Street, 410087, Craiova, Dolj, Romania, VÎLCEA Cristiana , NENIU Adelina
Published: November 2023

The rapid growth of urban areas and the increase in sealed surfaces have significant implications for environmental management and urban planning. Monitoring and quantifying sealed surfaces are crucial for understanding urbanization processes and their impacts. This article deals with the issues of mapping the dimension of soil sealing in Craiova city, during the last two decades using GIS and remote sensing techniques. As the Normalized Difference Built-up Index (NDBI) has emerged as a valuable tool for assessing sealed surfaces and evaluating urban expansion, it was selected as preferred method selected to determine the dimension of soil sealing.
Could the All-Inclusive system increase the appeal of the Romanian seaside?
Authors:   TERRA BLUE Travel & Holidays, 49 N. Titulescu Bvd., 200189, Craiova, Dolj, Romania, ALBĂ Claudia-Daniela , POPESCU Liliana ,   University of Craiova, Geography Department, 13 A.I. Cuza Street, 410087, Craiova, Dolj, Romania
Published: November 2023

The tourist infrastructure built during the Communist period on the Romanian seaside had a toilsome opening towards all-inclusive services, in 2023 less than 15% of the total number of hotels offering AI or AIL services. For the last 20 years, many Romanian tourists have become loyal to destinations abroad, easily accessible, some of them known to offer predominantly all-inclusive services. Using semi-structured interviews, the study analyzes the perception of a sample of Romanian tourists related to the development of the all-inclusive system on the Romanian seaside. Applying the thematic analysis procedure, 3 main themes emerged regarding the AI system: diversity, benefits for families and quality issues. Based on them, implications for managers and other stakeholders are discussed.
Radiation Therapy for Ocular Melanoma – a Narrative Review with Insides from TRIUMF, Canada’s Only Proton Beam Therapy Center
Authors:   West Point Grey Academy, Vancouver, Canada, Naus Andrew , Banyi Norbert ,   University of British Columbia, Faculty of Medicine, Vancouver, Canada, Ma Roy ,   BC Cancer, Department of Radiation Oncology
Published: November 2023

"Ocular melanoma (OM) originates from melanocytes in the eye, predominantly in the uvea, particularly the choroid. The yearly incidence is around six cases per million. OM is not primarily driven by ultraviolet exposure like skin melanoma, but is usually caused by mutations in GNAQ or GNA11. Symptoms like blurry vision and visual field defects appear late. Diagnosis is often made via eye exams, specialized ultrasound, and rarely biopsy. This narrative review describes the radiation treatment modalities of OM and highlights the landscape of proton beam irradiation in Canada. Historically, enucleation was the standard of care for OM. However, current strategies consider tumor size, location, patient age, visual potential, and metastatic presence. Primary treatments include radiation therapy and surgery. Radiation therapy includes plaque brachytherapy (PB), proton beam irradiation (PBI), stereotactic radiosurgery (SRS), and stereotactic radiotherapy (SRT). Surgery includes endoresection, exoresection, and enucleation. Tebentafusp-tebn has been FDA-approved for metastatic cases. PB, the most common radiation therapy for OM, involves radioisotopes delivering radiation into the tumor. Comparable survival rates between PB and enucleation for medium choroidal melanoma have made PB the standard of care. PB has certain limitations, mainly surgical complications. PBI uses a particle accelerator for focused, high-energy proton radiation, yielding high tumor control and survival rates, though the availability of proton facilities is a significant limitation. Vancouver is the only center in Canada for PBI, administered not in a healthcare facility but at TRIUMF (Tri-University Meson Facility). TRIUMF, the world's largest cyclotron particle accelerator, in partnership with BC Cancer and UBC Department of Ophthalmology and Eye Care Center, has treated over 200 ocular melanoma patients between 1995 and 2017, achieving a 91% tumor control rate and 82% five-year survival rate. Emerging combination therapies like Ataxia Telangiectasia Mutated (ATM) protein kinase inhibition before PBI show potential, possibly reducing radiation dose and resistance."
Valor nutricional e fatores antinutricionais da folha vegetal Talinum fruticosum
Authors: Leite Joana Filomena Magalhães , Silva João Andrade da , Gadelha Tatiane Santi , Gadelha Carlos Alberto , Siqueia Júnior José Pinto de
Published: November 2023

Talinum fruticosum Juss (L.) é uma planta não convencional da família Portulacaceae e trata-se de planta herbácea perene que cresce em regiões tropicais como vegetais folhosos. As plantas fornecem nutrientes essenciais ao organismo, no entanto, a biodisponibilidade pode ser comprometida pela presença de fatores antinutricionais tais como lectinas e taninos. Em virtude das folhas de T. fruticosum serem fonte de fibra e de minerais e por contribuem para reunir os micronutrientes necessários para a nutrição diária, no presente estudo as amostras de folhas dessa planta foram investigadas quanto à composição centesimal, bem como os fatores antinutricionais. As amostras foram submetidas ao tratamento térmico nos procedimentos de lavagem e de cozimento durante 10 min. Estes processos não foram capazes de alterar significativamente os teores de carboidratos e lipídeos, tampouco a supressão da atividade hemaglutinante que é inativada a 70°C. Contudo não houve eficácia na redução dos teores de tanino presentes nas folhas estudadas.
Influência da densidade de estocagem na composição química, no colesterol e no perfil de ácidos graxos em Tilápia do Nilo (Oreochromis niloticus LINNAEUS, 1857)
Authors: Menezes Maria Emília da Silva , Miranda Edma Carvalho de , Pinheiro Denise Maria , Cintra Felipe Tenório , Freire Moaceli de Magalhães , Cabral Júnior Cyro Rego , Sant'Ana Antônio Euzébio Goulart
Published: November 2023

Para avaliar a influência da densidade de estocagem na composição química, no valor calórico, no teor de colesterol e no perfil de ácidos graxos em Tilápias (Oreochromis nilotius, Linneaus, 1875), foram utilizados 120 alevinos com peso inicial médio de 4,0g,distribuídos em 20 aquários (70L cada um) em delineamento experimental inteiramente casualizado com 4 tratamentos, 50, 75,100 e 125peixes/m3 e 5 repetições. A ração fornecida continha 36% de proteína bruta e 3100k cal/ED/kg de ração. Ao final do cultivo, encontrou-se diferença significativa (p<0,05) na análise do peso médio final e no ganho de peso total entre as diferentes densidades populacionais testadas, sendo o maior peso encontrado para a densidade de 75peixes/m3. Com relação à análise da composição corporal observou-se diferença (ρ<0,05) entre as densidades para os teores de umidade; lipídeos totais; teor de proteína bruta, valor calórico e de colesterol. A relação poli-insaturados/saturados foi mais elevada na densidade de 100peixes/m3 (11,76), já a densidade de 50 peixes/m3 apresentou um somatório de (6,85) para os teores de EPA+DHA. Na avaliação da qualidade nutricional dos lipídeos, as densidades estudadas mostraram os índices de n-6/n-3, hipocolesterolêmicos/hipercolesterolêmicos (HH), índice de ácidos graxos poliinsaturados de aterogenicidade (IA) e índice de trombogenicidade (IT) favoráveis quanto ao consumo alimentar. Conclui-se que a densidade de 50peixes/m3 pode ser considerada uma boa fonte de ácidos graxos, principalmente de ácido ômega-3 e pelo seu valor em HH.
Lipídios totais e ácidos graxos na informação nutricional do rótulo dos alimentos embalados: aspectos sobre legislação e quantificação
Authors: Aued-Pimentel Sabria , Zenebon Odair
Published: November 2023

A ingestão excessiva de ácidos graxos saturados e trans na dieta tem sido correlacionada ao aumento do risco de doenças cardiovasculares. No Brasil, conforme a Resolução RDC 360/03 da Agência Nacional de Vigilância Sanitária (ANVISA) é exigida a declaração do teor de gordura total (GT) ou lipídios, ácidos graxos saturados (AGS) e trans (AGT) na rotulagem dos alimentos embalados, entre outros nutrientes, como estratégia de prevenção das doenças crônicas. Cabe aos laboratórios oficiais verificarem os teores declarados por meio da análise. No entanto, não estão uniformizadas as definições quanto aos componentes lipídicos, tão pouco quanto aos métodos analíticos a serem adotados, inclusive nos laboratórios brasileiros. Considerando-se as exigências legais, a diversidade dos métodos analíticos disponíveis e, principalmente, o direito do consumidor de obter informações confiáveis, a presente revisão teve como objetivo abordar aspectos sobre a legislação de rotulagem nutricional obrigatória dos alimentos, bem como sobre as etapas críticas dos métodos analíticos de quantificação dos componentes lipídicos. Estas etapas podem levar a divergências significativas nos teores obtidos para os nutrientes. Reforçam-se as evidências da necessidade de padronização das metodologias nos laboratórios brasileiros. Tal padronização contribuirá para garantir o direito do consumidor em obter informações uniformes e exatas sobre os alimentos que adquire, e possibilitará a escolha dos mais saudáveis, além de favorecer a inserção dos produtos brasileiros no mercado internacional.
Diagnóstico de infecção por vírus linfotrópicos de células T humanas dos tipos 1 (HTLV-1) e -2 (HTLV-2) em população de risco: passado, presente e futuro
Authors: Caterino-de-Araújo Adele
Published: November 2023

O Brasil é o país com o maior número de pessoas infectadas pelos vírus linfotrópicos de células T humanas dos tipos 1e -2 (HTLV-1 e HTLV–2) com mais de 2,5 milhões de indivíduos infectados. Em 1993, a realização de testes sorológicos específicos tornou-se obrigatória em Bancos de Sangue. O HTLV-1 causa leucemia/linfoma de células T do adulto e mielopatia associada ao HTLV-1/paraparesia espástica tropical além de outras doenças, enquanto o HTLV-2 pode causar alguns quadros neurológicos e alterar a evolução de HIV/Aids. Os testes sorológicos que identificam anticorpos específicos disponíveis no mercado têm falhado no diagnóstico, principalmente de infecção por HTLV-2. Vários algoritmos de testes de triagem e confirmatórios têm sido propostos, mas nenhum deles se mostrou 100% eficiente com casuística de alto risco. Muitos soros resultam em padrão indeterminado no Western blot, e os isolados virais utilizados na composição dos kits podem ser a causa desses resultados. As técnicas de biologia molecular têm sido descritas como testes confirmatórios, mas não têm sido empregadas na rotina. Desde 1991, a Seção de Imunologia do Instituto Adolfo Lutz tem estudado a infecção por HTLV-1/2, contribuindo para o diagnóstico sorológico e molecular, e tem como desafio implantar um teste laboratorial capaz de detectar infecção causada por cepas brasileiras de HTLV-2.
Falha na implantação de um novo algoritmo de testes laboratoriais para o diagnóstico de infecção por HTLV-1 e HTLV-2 em população de risco
Authors: Costa Emanuela Avelar Silva , Jacob Fabrício , Feliciano Regiane dos Santos , Santos-Fortuna Elizabeth de los , Caterino-de-Araújo Adele
Published: November 2023

Em vista dos problemas detectados no diagnóstico de infecção pelos vírus linfotrópicos de células T humanas dos tipos 1 e -2 (HTLV-1 e HTLV-2) em casuística encaminhada ao Instituto Adolfo Lutz de São Paulo, foi proposto um novo algoritmo de testes laboratoriais que utiliza duas amostras de sangue seqüenciais. Na primeira o sangue é coletado em tubo seco e feita triagem sorológica com dois ensaios imunoenzimáticos (EIAs). Na segunda, o sangue é coletado em tubo contendo o anticoagulante ácido etilenodiamino tetraacético (EDTA) para a repetição dos EIAs e para os testes confirmatórios de Western blot (WB) e reação em cadeia da polimerase (PCR). Os resultados obtidos com 313 amostras de sangue mostraram ineficiênciado algoritmo, pois nos casos EIA reagentes, apenas 25% tiveram uma segunda amostra de sangue coletada e destas, apenas três em EDTA. Portanto, não foi possível comparar o desempenho da PCR em relação ao WB. Um algoritmo simples, de coleta única de sangue em tubo contendo EDTA foi proposto e vem sendo utilizado para a triagem e para os testes confirmatórios.
Detecção de oocistos de Cryptosporidium spp e cistos de Giardia spp em mananciais e águas de abastecimento público
Authors: Stancari Regina Célia Arantes , Correia Marlene
Published: November 2023

O monitoramento de Cryptosporidium e Giardia é recomendado pela Portaria nº 518/2004/MS, pela possibilidade de causar doenças diarreicas na população, por veiculação hídrica. Neste estudo foram analisados a presença de oocistos e cistos, a qualidade microbiológica e físico-química, e os parâmetros físico-químicos foram correlacionados aos indicadores bacteriológicos com a presença desses parasitas em amostras de água de cinco municípios da DRS VI – Bauru. A metodologia USEPA 1623 foi utilizada na pesquisa dos protozoários e, para análises microbiológicas, foi seguida a metodologia do Standard Methods for the Examination of Water and Wastewater; e os métodos fotométrico, turbidimétrico, potenciométrico e colorimétrico foram utilizados nas análises físico-químicas. Cistos de Giardia foram encontrados em 10% das amostras e oocistos de Cryptosporidium não foram detectados. Todas as amostras de água tratada foram aprovadas nas análises microbiológicas, e 66,7% das amostras de água bruta não atenderam a legislação. Para a cor, 20% das amostras de água bruta estavam em desacordo com a legislação e 40% das águas tratadas apresentaram turbidez acima do limite seguro para remoção desses protozoários. A detecção de cistos de Giardia demonstrou a importância do monitoramento de águas para consumo, contudo não houve correlação entre a presença de cistos e os demais parâmetros avaliados.