bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring the Nexus of Tourism and Technology Acceptance: A Bibliometric Analysis
Authors: KALIPÇI M. Bahadır
Published: April 2024

This article offers a comprehensive bibliometric analysis examining the complex relationship between technological acceptance and tourism. The study examines 313 documents from 183 different sources between 1995 and 2023, with a primary focus on articles (n = 213). Key findings show that this research area first appeared in 1995 and that 856 authors contributed 966 times to its changing environment. Global collaborations are led by China, the USA, and, surprisingly, Malaysia; this highlights the international character of modern research. The selection of essential journals is guided by Bradford's Law, which emphasizes "Sustainability" as a key resource. Lodka's Law highlights the contributions of a small number of extremely productive writers while revealing complex authorship interactions. Information technology and user acceptance are two examples of thematic focal points that are found through word cloud analysis. Global research clusters are identified by Collaboration Network analysis across nations, organizations, and authors. These analyses provide important information for future research orientations, industry, and academia. This research adds to the growing body of knowledge regarding how technology affects travel by offering guidance to academics, industry professionals, and decision-makers on how to navigate this complex intersection.
Turizmde Sürdürülebilirliğin Bibliyometrik Analiz Yöntemi ile İncelenmesi (Investigation of Sustainability in Tourism Using Bibliometric Analysis)
Authors: HARMANDAROĞLU Seyda Fatih
Published: April 2024

Turizm dünyanın en geniş kapsamlı ve hareketli endüstrilerinden biridir. Turizm alanında öne çıkan paradigmalardan biri olan sürdürülebilir turizm konusunda alan yazında tartışma ve eleştiriler devam etmektedir. Bu makalenin amacı son yirmi yılda sürdürülebilir turizmdeki eğilimleri ve desenleri bibliyometrik analiz yöntemi ile araştırarak alana katkı sunmaktır. Araştırma kapsamında WoS veri tabanına erişim sağlanarak “*sustain* *tourism*” anahtar sözcükleri ile tarama gerçekleştirilmiştir. Elde edilen veriler öncelikle betimsel özellikler açısından, ardından VOSviewer programı yardımıyla atıf sayıları, ortak atıf, ortak yazarlık, birlikte bulunma ve bibliyografik eşleştirme analiz tipleri bakımından yazar, kurum ve ülkelere göre analiz edilmiştir. Araştırma bulguları, sürdürülebilir turizme dair araştırmaların son yıllarda dikkat çekici bir büyüme gösterdiğini ortaya koymakta ve araştırmaların yarıya yakınının son beş yılda gerçekleştirildiğini göstermektedir. Ayrıca en yaygın makale türlerinin ampirik çalışmalar ve eleştirel incelemeler olduğu anlaşılmaktadır. Analiz sonuçlarının araştırmacılara rehberlik edebilir nitelikte olduğu düşünülmektedir.
Uzak Doğu Restoranlarında Çalışan Bireylerin Gıda Neofobi Düzeylerinin Belirlenmesi: İstanbul ve Bodrum Örneği (Determination of Food Neophobia Levels of Individuals Working in Far Eastern Restaurants: Istanbul and Bodrum Example)
Authors: BÜYÜKYILDIRIM Cemile , GÜNEŞ Eda
Published: April 2024

Değişim ve yenilik olgusu, yaşamımızın her alanında var olan ve sonsuz olarak devam eden olgulardır. Bu iki olgu her sektörü etkilediği gibi yiyecek içecek sektörünü de büyük ölçüde etkilemektedir. Yiyecek-içecek sektörü yeniliğe açık olsa da tüketicilerin hepsi yeniliğe açık değildir. Yeni gıdalara açık olmama durumu yiyecekte yenilik korkusu (gıda neofobisi) olarak adlandırılmaktadır. Bu çalışma kapsamında Uzak Doğu restoranlarında çalışan Türk bireylerin gıda neofobi düzeylerinin değişkenlere göre belirlenmesi amaçlanmıştır. Bu kapsamda İstanbul ve Bodrum’da Uzak Doğu restoranlarında çalışan 168 bireye ulaşılmıştır. Araştırmada nicel araştırma yöntemlerinden yararlanılmıştır ve veri toplama aracı olarak anket formu kullanılmıştır. Katılımcılara toplam 10 tanımlayıcı soru ve 11 tane de gıda neofobisiyle doğru ya da ters orantılı olan ifadeler yöneltilmiştir. Elde edilen verilere çarpıklık-basıklık, frekans, t-testi ve varyans analizi uygulanmıştır. Betimleyici istatistiklere göre bireylerin yaş değişkenine göre anlamlı farklılık tespit edilmiştir (p<0,05). Çalışmada yer alan diğer değişkenlere göre gıda neofobisi kapsamında anlamlı bir farklılık ortaya çıkmamıştır.
Sivas Yerel Halkının Turizmin Gelişimine Yönelik Niyetsel ve Davranışsal Desteklerinin Belirlenmesinde Yer Aidiyetinin ve Turizm Etkilerinin Rolü (The Role of Place Attachment and Tourism Impacts in Determining Sivas Residents Intentional and Behavioral Support for Tourism Development)
Authors: KARACABEY Furkan Atasoy , ERUL Emrullah
Published: April 2024

Turizm faaliyetleri ekonomik ve sosyal gelişmeyi teşvik edebileceği gibi yerel halkın kültürüne ve doğal kaynaklarına zarar verebileceği de bilinmektedir. Bu nedenle turizmin ekonomik, sosyo-kültürel ve çevresel anlamda olumlu ve olumsuz etkilerinin yerel halk ile turizm gelişimi açısından desteklenip desteklenmediğinin ölçülmesi önemlidir. Genellikle yerel halk odaklı turizm gelişmeleri ile ilgili çalışmalar turizm açısından gelişmiş bölgelerde yapılmaktadır. Ancak mevcut çalışma, Sivas gibi turizm açısından yeterince gelişmemiş bir destinasyonda gerçekleştirilmiştir. Çalışmanın temel amacı, Sivas yerel halkının turizm gelişimine niyetsel ve davranışsal desteklerini, yer aidiyeti ve turizmin etkileri (olumlu ve olumsuz) faktörlerini kullanarak belirlemek ve literatürdeki bu boşluğu gidermektir. Çalışma kapsamında, Sivas'ta yaşayan 450 kişiye anket yapılmış ve elde edilen veriler, doğrulayıcı faktör analizi ve yapısal eşitlik modeli analizleri ile değerlendirilmiştir. Analiz sonuçlarına göre yer kimliği ile destekleme niyeti arasında bir ilişki saptanırken, yer bağlılığı ile niyetsel destek arasında bir ilişki saptanamamıştır. Ayrıca turizmin etkilerinin yer aidiyeti üzerinde etkili olduğu, niyetsel desteğin ise davranışsal desteği etkilediği tespit edilmiştir. Çalışmanın sonunda, sınırlılıklar ve öneriler sunulmuştur.
Gastronomi Turizminde Beslenme Engelleri Kapsamında Glütensiz Ürün Geliştirme: Coğrafi İşaretli Gaziantep Şekerli Böreği (Gluten-free Product Development within the Scope of Nutritional Barriers in Gastronomy Tourism: Gaziantep Sugar Pastry with Geographical Indication)
Authors: KASAR Hüsnü , MADENCİ Ayşe Büşra , SEÇİM Yılmaz
Published: April 2024

Başta buğday olmak üzere bazı tahılların yapısında bulunan glütenin son yıllarda çeşitli hastalıklar ile ilişkisi sıklıkla değerlendirilen konulardan biri olmuştur. Bu durum gıdaların glütensiz olarak üretilmesine ve buğday ununa alternatif ürünlere yönelik talebi arttırmıştır. Glütensiz ürün pazarı son yıllarda hızla büyürken buğday temelli yöresel ürünlerin bu pazardaki yeri sınırlı durumdadır. Yöresel ürünlerin glütensiz alternatiflerinin üretilmesinin gastronomi turizmine katkı sağlayacağı düşünülmektedir. Bu çalışmada, Gaziantep mutfağında sıklıkla tüketilen coğrafi işaretli tescillenmiş şekerli böreğin glütensiz olarak üretilmesi amaçlanmıştır. Bu kapsamda mısır unu, karabuğday unu, keçiboynuzu unu ve pirinç unu kullanılmış ve ayrıca buğday unu ile kontrol örneği hazırlanmıştır. Üretilen şekerli börek örneklerinin duyusal analizleri gerçekleştirilmiş ve duyusal özelliklerde istatistiki açıdan farklılık olup olmadığı gözlemlenmiştir. Tüketiciler tarafından glütensiz şekerli börek örneklerinin beğenilme düzeylerini tespit etmek amacıyla renk, tat, koku, yumuşaklık, çiğneme özelliği ve genel beğeni parametrelerinden oluşan duyusal analizler Muş Alparslan Üniversitesi Çölyak ve Glütensiz Beslenme Topluluğu ile Aşçılık programı ön lisans öğrencilerinden oluşan gönüllü yarı eğitimli panelistlere uygulanmıştır.
Türkiye nin Binicilik Turizmi Potansiyelinin İncelenmesi (The Examination of Türkiye s Equestrian Tourism Potential)
Authors: DEĞİŞGEL Sedat
Published: April 2024

Dünya genelinde turizmin gelişmesine paralel olarak talep gören turizm aktivitelerinden birisi de biniciliktir. Bu çalışmanın temel amacı, Türkiye’nin sahip olduğu binicilik turizmi potansiyelinin bütüncül bir yaklaşımla ele alınarak incelenmesidir. Özellikle Türkçe turizm literatüründe binicilik turizminin bağımsız ve bütüncül olarak incelendiği özgün çalışmalar konusunda bir boşluk olduğu görülmüştür. Bu çalışmanın bu boşluğu dolduracağı ve binicilik turizmi ile ilgili yapılacak farklı araştırmalara kaynak niteliği taşıyacağı düşünülmektedir. Betimsel bir araştırma olan bu çalışmada, belge taraması yöntemi kullanılmıştır. Araştırma kapsamında Türkçe ve yabancı alan yazın, binicilik ve turizm olguları ekseninde tarama modeli uygulanarak incelenmiştir. Çalışma sonucunda, Türkiye’nin dünyada binicilik turizminden yüksek gelir elde eden birçok ülkeye kıyasla önemli avantajlara sahip olduğu ancak bu potansiyelin henüz yeterince kullanılmadığı ortaya çıkmıştır. Bunun yanı sıra Türkiye’de binicilik turizminin geliştirilmesi ile, coğrafi ve iklimsel koşullar fark etmeksizin Türkiye’nin her bölgesinde on iki ay turizm hareketliliğinin sağlanabileceği, bu sayede ekonomik sorunların ve göç sorununun çözümüne katkı sağlanarak kırsal kalkınmanın doğayla uyumlu sürdürülebilir şekilde artırılabileceği sonuçlarına ulaşılmıştır.
Bedevi İmajından Gastronomi Merkezliğine: Körfez Ülkelerinde Gastrodiplomasi Uygulamaları (From Bedouin Image to Gastronomy-Centeredness: Gastrodiplomacy Practices in Gulf Countries)
Authors: TÜYLÜOĞLU Esra
Published: April 2024

Yıllar içerisinde yemek yemek fizyolojik bir eylem olmanın ötesine geçip, kültürel bir unsur haline gelmiştir. Yiyecekler bulundukları milletlerin kültürünü de temsil etmekte, bu yönüyle de ülkelerin yemek kültürleri, kültürlerarası iletişim ve etkileşim aracına dönüşmektedir. Günümüzde ülkeler için diğer ülke halkları nezdinde mevcutta var olan önyargıları yıkmak ve yanlış anlaşılmaları düzeltmek önem arz etmektedir. Gastrodiplomasiden faydalanan ülkeler, mutfak kültürleri sayesinde diğer ülkelerin halkları üzerinde olumlu bir ülke imajı yaratmaya çalışmaktadır. Bu çalışmada Katar, Birleşik Arap Emirlikleri ve Suudi Arabistan Krallığı özelinde Körfez ülkelerinin gastrodiplomasi uygulamalarının incelenmesi amaçlanmıştır. Derinlemesine literatür çalışması sonucu hazırlanan araştırmada üç ülkenin geçmişten bugüne gastrodiplomasi alanındaki çalışmalarına yer verilmiş ve bu çalışmalardan hareketle gastrodiplomasi alanının önemi tartışılmıştır. Yapılan incelemelerde bilhassa XXI. yüzyılın başından itibaren oryantalist tasvirlerdeki “Ortadoğulu profili” ile özdeşleşen petrolün ve “thobe” adı verilen beyaz entarilerin en yaygın olarak görüldüğü Körfez Bölgesi’nde hem ekonominin güçlendiği hem de ülkelerin her geçen gün daha fazla turist çekme arayışları ön plana çıkarttıkları tespit edilmiştir. Çalışmada misafirperverliği ve kalabalık sofraları ile ünlü olan Körfez ülkelerinin, yemek ve sofra kültürüne diplomatik temaslarda da olağanüstü önem vermeye başladığı sonucuna ulaşılmıştır. Yapılan alanyazın taramasında özellikle Körfez bölgesine ve çalışma özelinde araştırılan üç ülkeye ilişkin bilimsel çalışmaların sayısının çok az olması çalışmayı özgün kılarken, aynı zamanda bu alanda çalışma yapmayı düşünenler için de kaynak olacağı öngörülmüştür.
A STUDY ON HUMAN RIGHTS VIOLATIONS AND DOMESTIC VIOLENCE
Authors:   Research Scholar, Department of Law, Shri JJT University., S. Nair Reshmi , Gupta Kavita ,   Research Guide, Assistant Professor, Shri JJT University, Rajasthan.
Published: April 2024

Domestic violence, a grave issue that spreads geographic, cultural, and socioeconomic boundaries, is a problem that has existed for centuries. It involves a range of abusive behaviour within intimate relationships, often causing physical, emotional, and psychological harm to victims.As a grave violation of human rights, domestic abuse is examined in-depth in this article. The definitions, prevalence, and various forms of domestic violence, bringing to light the significant effects and challenges it has on victims and the community at large are being dealt into.
RARE CAS DE MACRO-PROLACTINOME GEANT SIMULANT UN CRANIOPHARYNGIOME
Authors:   Department of Endocrinology, Diabetology, Metabolic Diseases and Nutrition. Hassan II University Hospital. Fez. Morocco., Es-Souabni A. , Melki F. El ,   Department of Endocrinology, Diabetology, Metabolic Diseases and Nutrition. Hassan II University Hospital. Fez. Morocco., Henda S. ,   Department of Endocrinology, Diabetology, Metabolic Diseases and Nutrition. Hassan II University Hospital. Fez. Morocco., Aynaou H. ,   Department of Endocrinology, Diabetology, Metabolic Diseases and Nutrition. Hassan II University Hospital. Fez. Morocco.,   Laboratory of Epidemiology, Research in Health Sciences, Faculty of Medicine and Pharmacy, USMBA, Fez, Morocco., Salhi H. ,   Department of Endocrinology, Diabetology, Metabolic Diseases and Nutrition. Hassan II University Hospital. Fez. Morocco.,   Laboratory of Epidemiology, Research in Health Sciences, Faculty of Medicine and Pharmacy, USMBA, Fez, Morocco.
Published: April 2024

Bien que le craniopharyngiome reste la tumeur sellaire et supra-sellaire la plus frequemment caracterisee parpresence des calcifications, celles-ci sont tres rarement observees dans les adenomes hypophysaires posant ainsi un probleme de diagnostic differentiel et de prise en charge. Nous rapportons un cas tres rare de prolactinome geant invasif et calcifie donnant un aspect radiologique inhabituellement identique a celui dun craniopharyngiome chez un jeune homme de 30 ans, raison pour laquelle il a beneficie initialement dun traitement chirurgical, puis readresse a notre formation pour evaluation post-operatoire, oÃ¹ le bilan endocrinien est revenu en faveur dune hyperprolactinemie avec taux tumoral. Lhistopathologie a confirme le diagnostic de prolactinome calcifie.
THEME: EVALUATION OF THE TECHNIQUE OF PERFORMING ANGIO-SCANNING AT CHME LUXEMBOURG
Authors:   Radiology Department of the Mother-Child University Hospital Center Luxembourg (Bamako, Mali)., Kouma Alassane ,   Faculty of Medicine and Odontostomatology (FMOS)., Dembele Mamadou ,   Faculty of Medicine and Odontostomatology (FMOS)., Coulibaly Sylvain ,   Radiology Department of the Mother-Child University Hospital Center Luxembourg (Bamako, Mali)., Drako Nouhoum ,   Radiology Department of the Mother-Child University Hospital Center Luxembourg (Bamako, Mali)., Sanogo Souleymane ,   Radiology Department of the Mother-Child University Hospital Center Luxembourg (Bamako, Mali).,   Faculty of Medicine and Odontostomatology (FMOS)., Diarra Oucoumba ,   Radiology Department of the Mother-Child University Hospital Center Luxembourg (Bamako, Mali).,   Faculty of Medicine and Odontostomatology (FMOS)., LY Seydou ,   Radiology Department of the Mother-Child University Hospital Center Luxembourg (Bamako, Mali)., Cisse Issa ,   Radiology Department of the Mother-Child University Hospital Center Luxembourg (Bamako, Mali).,   Faculty of Medicine and Odontostomatology (FMOS)., Zoumana Berete Cheick ,   Department of Teaching and Research in Public Health and Specialties (DERSP) (Bamako, Mali)., Diaman Keita Adama ,   Faculty of Medicine and Odontostomatology (FMOS).,   Urology Department of the G Point University Hospital Center (Bamako, Mali)., Sidibe Siaka ,   Faculty of Medicine and Odontostomatology (FMOS).
Published: April 2024

Objectives :Evaluate the technique of performingangio-scanning at CHME Luxembourg. Methodology: This is a 2-month prospective and descriptive studyfrom April 1 to May 31, 2021. Any patient presenting an examination bulletin sent to the imagingdepartment for angio-CT and havingagreed to participate in ourstudy. Results:Duringourstudyperiod, 1025 CT scans wereperformed, amongwhichwefound 78 angio-CT scans, representing a frequency of 7.60%. Among the 78 cases of CT angioperformed, weidentified 61 angio-thoracic (78.20%), 7 lowerlimbangio (7.90%), 5 thoraco-abdominopelvicangio-CT (6.40%). , 3 cerebral CT angio-CT (3.80%) 1 CT angiogram of the upperlimbs and the aortawith a frequency of 1.30% each. The averageage of our patients was 57 yearswithextremes of 1 month (born) and 82 years. The femalegenderwas the mostrepresentedwith 53%. Dyspnea and chest pain were the mostcommonclinicalfindings. Meglumineioxitalamate (TÃƒÂ©lÃƒÂ©brix*) was the mostusediodinatedcontrastproductwith 65.4%. The average flow rate was 3.92 ml/s in ourstudy. The average value of Dose-Length-Product (DLP) per acquisition was 353.79 mGy.cm withextreme values Ã¢Â€Â‹Ã¢Â€Â‹of 91 to 775mGy.cm. Hot flashes were the mostfrequentlyencounteredsideeffect in our patients with a frequency of 26.9%. Among the angio-TTDM performed, 80.8% of ourexaminationscorresponded to the successcriteria Conclusion: The CT angiography technique remains the gold technique for the exploration of veins and arteries. In the majority of cases it leads to a satisfactorydiagnosis.
POSTOPERATIVE RADIOTHERAPY IN SALIVARY DUCTCARCINOMA: A CASE REPORT AND REVIEW OF THE LITERATURE
Authors:   Radiotherapy Department, Mohammed VI University Hospital Center, Tangier, Morocco., Morchid S. , Sellal N. ,   Radiotherapy Department, Mohammed VI University Hospital Center, Tangier, Morocco., Chellakhi M. ,   Radiotherapy Department, Oncology Center of Tangier, Tangier, Morocco., Hfid M. El ,   Radiotherapy Department, Mohammed VI University Hospital Center, Tangier, Morocco.
Published: April 2024

Salivary duct carcinoma(SDC) is a rare and aggressive tumor of the salivary glands that often occurs in men between the fifth and sixth decades of life. standard treatment is based on wide surgical resection of the primary tumor with lymph node dissection, followed by postoperative radiotherapy. The place of chemotherapy in the treatment of SDC remains unknown. In this publication, authors report a case of SDC of the left parotid gland. A 28-year-old male suffered from a painful neck mass associated with hearing loss that had been evolving for 6 months. The patient initially had a cervical CT scan and a parotid MRI, which showed a tumor of the left parotid gland. He initially had a total parotidectomy preserving the facial nerve with an ipsilateral neck dissection, as the intraoperative histological examination was in favor of malignancy. The final analysis of the surgical specimen concluded to a ductal carcinoma of the parotid with lymph node metastasis. Adjuvant radiation therapy has been indicated. The evolution was unfavorable due to the appearance of multisite metastases after one year.
CONGENITAL TRICHOFOLLICULOMA: A CASE REPORT
Authors:   Final Year Post Graduate, Department of DVL, Narayana Medical College, Nellore, 524003., Ravalika B.T , Chakravarthy N. ,   Assistant Professor, Department of Dvl, Narayana Medical College, Nellore, 524003., Vijaya Mohan Rao A. ,   Professor and Head of Department, Department of DVL, Narayana Medical College, 524003.
Published: April 2024

Congenital trichofolliculoma is a rare benign cutaneous tumor characterized by the presence of hair follicles in different stages of development within a dilated central follicular cavity.Veryrarely congenital cases have been reported.We present a case of fiveyearold girl with an asymptomatic hairy elevated lesion on her nose since birth. Laboratory investigations revealed normal complete blood picture,liver functionand renal function tests. Dermoscopy showed small tuft of hair protuding from centre of lesion. Skin biopsy confirmed the diagnosis of congenital trichofolliculoma. Simple surgical excision of the lesion was performed, resulting in complete healing without scarring. This case highlights the importance of recognizing and managing congenital trichofolliculoma in pediatric patients.
ASTAXANTHIN SYNTHESIS IN SYNECHOCOCCUS PC7002: OPTIMIZATION AND PRODUCTSECRETIONTO CULTURE MEDIUM
Authors:   Applied Plant Sciences, Department of Biology, Technical University of Darmstadt, SchnittspahnstraÃŸe 1064287 Darmstadt., Greulich Simon , Kaldenhoff Ralf ,   Applied Plant Sciences, Department of Biology, Technical University of Darmstadt, SchnittspahnstraÃŸe 1064287 Darmstadt.
Published: April 2024

Synechococcus sp. PCC7002 can produce theastaxanthin precursor Î²-carotene but not astaxanthin.Using a synthetic ketolase-and a synthetic hydroxylase-gene we modifiedSynechococcuscarotene metabolism to produce astaxanthin. The total cellular content of astaxanthin was further increased by over-expressing the intrinsic phytoene synthase. Besides a beneficial step in astaxanthin production our results indicate for some modifications in the suggestedprocess of carotenoid metabolism. In addition, we were expressing an E. coli ABC-transporter to export astaxanthinand decrease intracellular product accumulation. By this, the synthesis was increased further and significant amounts of astaxanthin can be recovered from culture medium without cell destruction.
A CASE REPORT OF MYELOMENIGOCELE WITH ARNOLD CHIARI MALFORMATIN II-HIGHLIGHTING THE IMPORTANCE OF ANEMIA MUKTH BHARATH PROGRAMME
Authors:   Postgraduate Student., Shirisha Danavath , a Sreelatha ,   Associate Professor, Dept of Obstetrics &Gynaecology, Kurnool Medical College, Kurnool.
Published: April 2024

Introduction:Neural tube defects are common complex congenital malformations resulting from failure of neural tube closure during embryogenesis, which usually completes by 28 days post conception. Myelomeningocele is almost always associated with Arnold Chiari Malformation II (CM II)and vice versa. Aims &Objectives : As most of the neural tube defects can be prevented by pre-conceptional folate supplements, we would like to high light the importance of proper implementation and utilization of Anemia Mukhth Bharath Programme. Background: Neural tube defects (NTDs) are caused by a combination of multiple genes and multiple environmental factors like folic acid deficiency, insulin dependent diabetes, obesity and certain medications which interfere with folate metabolism.One of the beneficiaries under the Anemia Mukth Bharath programme are women in the reproductive age group in the pre-conception period and up to the first trimester of the pregnancy. They are advised to have400 mcg of Folic Acid tablets, daily, to reduce the incidence of neural tube defects in the fetus. Case report :We present a case of Chiari malformation associated with megaloblastic anemia with an attempt to highlight the importance of proper utilization of national program for prevention of iron and folate deficiency in women of reproductive age group. Clinical relevance : Neural tube defects are largely preventable anomalies by simple and effective management of folate deficiency preconceptionally. Conclusion :Proper utilization of the Anemia Mukth Bharath program which is available to the beneficiaries at their doorstep can not only prevent maternal anemia but also prevent fetal loss due to NTD.
MAFFUCCI SYNDROME, UNILATERAL LOWER LIMB INVOLVEMENT WITH GROSS SHORTENING: A CASE REPORT
Authors:   Consultant Orthopaedic Surgeon, Oberoi Hospital, Jalandhar City, Punjab, MS, DNB Orthopaedics Postal Address- Oberoi Hospital, 8 Gujral Nagar, Jalandhar City, Punjab, India., Singh Oberoi MS. DNB Ortho Harsharan , Singh Oberoi MS Ortho MPH Baldish ,   Pathologist, Gargi Diagnostic lab 202/5 Gujral Nagar, Jalandhar City, Punjab, India., Sharma MD Pathology Gargi ,   Postal Address of the hospital where work was done- Oberoi Hospital, 8 Gujral Nagar, Jalandhar City, Punjab, India, Pin code-144001.
Published: April 2024

Maffuci syndrome is a rare type of multiple enchondromatosis associated with hemangiomas in soft tissues. The presence of hemangiomas and a very high risk of malignant transformation of enchondromas to chondrosarcomas differentiates Maffucci syndrome from Olliers disease.We report a case of9 years old girl child with multiple enchondromas and hemangiomas. She had shortening and deformity of left lower limb, fracture of left tibia following a trivial trauma, and a history of surgical interventions to correct valgus deformity at the knee by figure of 8 plating and nailing and bone grafting for fracture tibia that failed to unite. X-rays were suggestive of multiple enchondromas affecting the bones unilaterally, of only the left lower limbs with multiple lesions in the left femur, tibia and fibula. The right lower limb was normal. The resultant shortening was 6.5 inches (16.5 centimeters.).There was, in addition, a painful, warty growth in the lower third of the posterior aspect of the left thigh measuring 1.5 cm x 1.5 cm.An excisional biopsy was done and the histopathology report was a Hemangioma. The child was diagnosed as a case of Maffucci syndrome. The child was fitted with a KAFO with an extension prosthesis (a double decker).
Editorial
Authors:   UNSW Sydney, Jung Jae Yup
Published: April 2024

Welcome to the first issue of the Australasian Journal of Gifted Education for 2024. In this issue of the journal, we have three highly interesting articles that each delve into different aspects of giftedness and gifted education, that have been prepared by emerging and established scholars in the field. The fourth article is an interview of Genevieve Thraves, who is an author of one of the articles in this issue, and a regular contributor to the Australasian Journal of Gifted Education. The preparation of this issue was possible due to the contributions of Margaret Plunkett and Geraldine Townend, as acting editors on those articles on which I was coauthor, and Marie Young, who interviewed Genevieve Thraves and provided copyediting support.
El Platón de Hegel: propiedad privada y libertad subjetiva
Authors: Gutiérrez Alejandro Mauro
Published: April 2024

En este artículo analizo la interpretación de Hegel de la filosofía política platónica (particularmente la República) en determinados pasajes de dos obras puntuales: los Fundamentos de la filosofía del derecho y las Lecciones sobre Platón. Considero dos ejes específicos de análisis: la propiedad privada y la libertad subjetiva. El objetivo del artículo es señalar la relación que Hegel establece con Platón o, al menos, con República. Muestro que, en realidad, en este diálogo existen ciertos matices con respecto a los dos ejes mencionados; estos matices implican diferencias de análisis respecto de la lectura hegeliana.
¿Es el acto algo real? Hipótesis para solucionar algunos problemas derivados de la interpretación praxeológica del concepto noológico de “acto”
Authors: Prada Rodriguez Manuel Leonardo
Published: April 2024

La primera parte de este artículo expone la interpretación praxeológica del concepto noológico de “acto”. En la segunda, se muestra la crítica que Antonio González Fernández hace de esta. Su objeción consiste en que los actos no pueden ser considerados cosas reales, sino solo el surgir de estas. A partir de dicha observación a la noología, González Fernández no solo da surgimiento a su praxeología (también conocida como hiparqueología), sino que su sistema filosófico comienza a ser cuestionado por no explicar qué son, en el mundo de los hechos, los actos, más allá de la suposición de que ellos están ahí a pesar de ser invisibles. En la tercera y última sección se presentan algunas hipótesis para procurar solucionar ciertas objeciones al concepto praxeológico de “acto”, tales como el anteriormente mencionado y las aparentes circularidades y posibles contradicciones que hay al interior del sistema praxeológico.
Hacerse cargo. Reflexiones acerca de la memoria, el juicio y el perdón
Authors: Muñoz Sánchez María Teresa
Published: April 2024

Este artículo está motivado por el problema de la responsabilidad colectiva frente a las acciones cometidas por nuestros antepasados y por la pregunta acerca de la legitimidad de las demandas de perdón. Acudiendo al universo conceptual heredado de Hannah Arendt, en este texto se aboga por el ejercicio de la capacidad de juicio como detonante tanto de la demanda de perdón como de la responsabilidad colectiva. El perdón se presenta así no solo como una categoría moral sino fundamentalmente política, imprescindible para reconciliarse con lo acontecido y mirar al futuro con esperanza.
Development of Cross-Linked Gelatin Hydrogel Films Using Tannic Acid as Anti-Aging Active with Skin Care Potential
Authors: de Oliveira Gabriele , Zamataro Isadora , de Oliveira Mariana , Gomes André , Barros Maria Gabriela , Oliveira Angélica , Zanella Karine , Gonçalves Caroline
Published: April 2024

Hydrogel films based on gelatin, glutaraldehyde and glycerol are widely reported in many studies with applications focused on food packaging, microencapsulation and release of active drugs. Thus, this study used this composition to produce hydrogel films and brought as a novelty the incorporation of tannic acid (TA) as anti-aging active, due to its great antioxidant capacity. The presence of TA in the hydrogel films was verified by the C-O stretch absorption band at 1020 cm-1, as well as by its thermal degradation between 200 and 300 ºC. Furthermore, the presence of this active compound, which influenced the physical, morphological and mechanical properties of the film, was also confirmed by qualitative release tests. Additionally, the mechanical properties of the HT2 hydrogel film showed acceptable values of elongation at break (28.9 ± 3.1%) and Young modulus (6.4 ± 1.1 MPa), suggesting that this film has the potential to be applied in skin care routines.
Methodology for assessing the level of development and efficiency of the functioning of the traffic management system, taking into account the environmental factor
Authors: Tulenov Aidarali , Baubekov Yermek , Bakyt Gabit , Bekbolatov Gabit , Tanshanlo Mansur
Published: April 2024

The scientific article presents a methodology for assessing the level of development and efficiency of traffic management systems, taking into account environmental factors. The order and algorithms for all calculations to assess the level of effectiveness for road traffic management systems of motor transport, while taking into account the impact of environmental factors, are provided. The methodology for assessing the current state of the traffic management system relies on the degree of deviation of each individual indicator from its target value. The resulting value of the composite indicator for the system’s condition is then compared to its standard value, and an estimated overall state for the system is determined. According to some indicators, there has been an increase in emissions of toxic substances in the city's streets and roads, which are assessed as “poor”. To improve the state of the environment, an immediate set of organizational and technical measures has been proposed for the rational development of the traffic management system.
A Systematic Review on the Evolution of Natural Mutation-dependent Antiviral Drug Resistance in Hepatitis C Virus (HCV) Genotypes Prevalent in Saudi Arabia: A Genomic and Therapeutic Perspective
Authors: Izhari Mohammad Asrar
Published: April 2024

Background:

The characterization of resistance-associated amino acid substitution
(RAAS) in direct-acting antivirals (DAA) molecular targets could reshape the treatment strategy for
HCV infection. Hence, this review aimed to provide evidence on the impact of the RAASs on DAA
treatment for HCV.

Methods:

PRISMA model was followed for the literature survey and evaluation (sources: PubMed,
Sci-Hub, and Google Scholar). RAASs in DAA target proteins and their locations were mapped on
3-D proteins using two reference protein sequences: NS3/ID: AAA72945.1 and NS5A/NS5B/ID:
NP_671491.1. NCBI-Basic Local Alignment Tool, UniProt and AlphaFold2/MMSeqs2, PyMol, and
R-base/R-studio were used for alignment, retrieval of protein sequences, 3-D protein structure modeling,
visualization of locations of RAASs, and diagrammatic representations, respectively.

Results:

Genotype 4 afterwards genotype 1 was the most prevalent in Saudi Arabia. L2003M,
Y2065N, M2000T, L2003V, and Q2002H RAASs were anti-NS5A inhibitor. NS5A-Q2002H was
anti-daclatasvir in genotype 4. NS5A-Y2065H and NS5B-S2702T in genotype 1 were antisofosbuvir-
resistant. NS3-A1182V, NS3-Q1106K/R, and NS3-T1080S RAASs exhibited resistance
to double antivirals. NS3-D1194A RAAS was a multi-drug resistant variant (against 3 DAAs). NS3-
V1062A, NS3-D1194G, NS3-D1194E/T, NS3- S1148R, NS3-V1196A, NS3-V1062LNS3-S1148A,
and NS3-S1148G RAASs in genotype 1 were single drug-resistant variants. NS3- S1148R and NS3-
S1148A in genotypes 2 and 5 were anti-simeprevir-resistant variants.

Conclusions:

An array of identified RAASs, RAAS-dependent DAA treatment failure, and recommended
combination DAA therapy in such clinical scenarios of RAASs are the significant outcomes
of this research. RAAS-linked in vitro and in vivo resistance profiling at genotype/sub-genotype level
will be crucial in treatment choice and for future DAA design strategies.
Role of miRNAs in Brain Development
Authors: Sharma Himanshu , Kaushik Monika , Goswami Priyanka , Sreevani Sanakattula , Chakraborty Ananya , Ashique Sumel , Pal Radheshyam
Published: April 2024

Non-coding RNAs that are small in size, called microRNAs (miRNAs), exert a conse-quence in neutralizing gene activity after transcription. The nervous system is a massively ex-pressed organ, and an expanding body of research reveals the vital functions that miRNAs play in the brain's growth and neural activity. The significant benefit of miRNAs on the development of the central nervous system is currently shown through new scientific methods that concentrate on targeting and eradicating vital miRNA biogenesis pathways the elements involving Dicer and DGCR8. Modulation of miRNA has been associated with numerous essential cellular processes on neural progenitors, like differentiation, proliferation, and destiny determination. Current re-search discoveries that emphasize the significance of miRNAs in the complex process of brain development are included in this book. The miRNA pathway plays a major role in brain devel-opment, its operational dynamics, and even diseases. Recent studies on miRNA-mediated gene regulation within neural discrepancy, the circadian period and synaptic remodeling are signs of this. We also discussed how these discoveries may affect our comprehension of the fundamental processes behind brain diseases, highlighting the novel therapeutic opportunities miRNAs pro-vide for treating various human illnesses.
Correlación entre teorías constitucionales y métodos de interpretación: la eutanasia como caso de estudio en Colombia
Authors: Mondragón Duarte Sergio Luis , Guzmán Quintero Aldemar , Franco Mateus Laura Marcela , Sánchez Rengifo Sergio Luis
Published: April 2024

Introduction: The text addresses the relationship between constitutional theories and methods of interpretation, using euthanasia in non-terminal illnesses in Colombia as a case study. Objective: Determine the relationship between constitutional theories and interpretation methods in the context of euthanasia, highlighting the change in Colombian jurisprudence in 2020. Reflection: The application of interpretation methods by the Constitutional Court in specific cases, such as Martha Liria, is evident. Sepúlveda and Víctor Julio Escobar, based on the analysis made in this regard from constitutional theories, such as the original, customary law, judicial activism and approaches of authors such as Dworkin, Alexy, Habermas and Nino. Which results in generating an impact on the fundamental guidelines and principles for constitutional interpretation, as well as different types of interpretation, such as authentic, doctrinal and judicial. Conclusion: The importance of having interpretation methods to guarantee rights in modernStates is highlighted, highlighting the complexity and dynamism of the constitutional interpretation process, making it pertinent to establish a more deep-rooted connection between constitutional theories and interpretation techniques in the context of euthanasiain Colombia, analyzing specific cases and providing data on its practice in the country.
Ambiguity, Ambivalence, and Activism: Data Organizing Inside the Institution
Authors: Horgan Leah , Dourish Paul
Published: April 2024

Investigations of data-centered efforts in advocacy and activism are often cast in terms of a narrative of opposition between grassroots activists working through and with data, and corporations or institutions whose actions data might expose. The boundaries are, however, not so distinct in practice. Indeed, one outcome of successful advocacy efforts for opening big data to the public is that the activists may find themselves drawn into the institutions they critique or view as impediments in order to actualize those efforts from the inside. Drawing on an ongoing ethnographic investigation of urban data initiatives inside city government, we explore the productive ambivalences of activism and advocacy that arise when those with data activist ideals find themselves operating within the government structure.
Analisis Hubungan Self-Efficacy dan Representasi Matematis terhadap Pemecahan Masalah Matematis
Authors: Supriadi Nanang , Sari Anggun Lupita , JL Ana Risqa
Published: April 2024

Pemecahan masalah merupakan hal dasar yang seharusnya dimiliki siswa, terutama dalam mempelajari matematika, jika pemecahan masalah yang dimiliki baik maka kemampuan matematika nya juga akan baik. Penelitian ini memiliki  tujuan untuk mengetahui hubungan langsung maupun tidak langsung antara self-efficacy, dan representasi matematis terhadap pemecahan masalah matematis siswa. Penelitian ini menggunakan pendekatan kuantitatif dengan jenis penelitian ex post facto. Populasi dalam penelitian ini seluruh siswa SMP Negeri di Kebupaten Pesawaran Provinsi Lampung. Teknik pengambilan sampel yang digunakan yaitu stratified random sampling jumlah strata sebanyak 3 dan untuk masing-masing strata berjumlah 24, 30 dan 26 siswa, kemudian dengan menggunakan rumus slovin maka diperoleh jumlah sampel sebanyak 60 siswa. Instrumen yang digunakan dalam pengumpulan data berupa angket self-efficacy serta tes kemampuan pemecahan masalah matematis dan representasi matematis. Hasil dari penelitian ini menunjukkan bahwa terdapat hubungan langsung positif dan signifikan antara self-efficacy terhadap representasi matematis, serta representasi matematis  dan self-efficacy terhadap pemecahan masalah matematis, juga representasi matematis secara signifikan memediasi hubungan tidak langsung antara self-efficacy terhadap pemecahan masalah matematis. Problem-solving is a basic thing that students should have, especially in mathematics lessons, if the problem-solving they have is good then their math skills will also be good. This study aims to determine the direct or indirect relationship between self-efficacy and mathematical representation of students' mathematical problem-solving. This study uses a quantitative approach to the type of research ex post facto. The population in this study were all-state junior high school students in Pesawaran District, Lampung Province. The Slovin formula was used to determine the number of samples, a sample of 60 students was obtained and the sampling technique used was stratified random sampling. The instruments used in data collection were self-efficacy questionnaires and tests of mathematical problem-solving abilities and mathematical representations. The results of this study indicate that there is a direct relationship between self-efficacy on mathematical representations, as well as mathematical representations and self-efficacy on solving mathematical problems. Mathematical representations also significantly mediate the indirect relationship between self-efficacy on mathematical problem-solving.
Review on the Development of Titanium Diboride Ceramics
Authors: Lv Xinran , Yin Ziqiang , Yang Zhigang , Chen Junshuai , Zhang Shen , Song Shaolei , Yu Gang
Published: April 2024

Titanium diboride (TiB2) materials have garnered significant attention due to their remarkable comprehensive properties. They offer potential applications in high-temperature structural materials, cutting tools, armor, electrodes for metal smelting, and wear-resistant parts. However, due to the low self-diffusion coefficient, the TiB2 exhibits poor sinterability, excessive grain growth at elevated temperatures, and inadequate oxidation resistance, limiting its wide application. Therefore, many research works are devoted to processing TiB2 at a lower sintering temperature and improving the properties through various sintering additives and more advanced techniques. This article comprehensively reviews the multiple synthesis methods and sintering technologies of TiB2, and at the same time, critically discusses the impacts of sintering additives and reinforcing agents on densification, microstructure, and various properties, including those at high temperatures, and finally predicts the future development of TiB2 composite materials.
Telemedicine With Wearable Technologies in Patients Undergoing Hematopoietic Cell Transplantation and Chimeric Antigen Receptor T-Cell Therapy (TEL-HEMATO Study): Prospective Noninterventional Single-Center Study
Authors: Hurtado Lidia , Gonzalez Concepcion Melinda , Flix-Valle Aida , Ruiz-Romeo Marina , Gonzalez-Rodriguez Sonia , Peña Marta , Paviglianiti Annalisa , Pera Jambrina Maria Angeles , Sureda Anna , Ochoa-Arnedo Cristian , Mussetti Alberto
Published: April 2024

Background

Patients with hematological malignancies receiving hematopoietic cell transplantation (HCT) or chimeric antigen receptor (CAR) T-cell therapy are at risk of developing serious clinical complications after discharge.

Objective

The aim of the TEL-HEMATO study was to improve our telehealth platform for the follow-up of patients undergoing HCT or CAR T-cell therapy during the first 3 months after discharge with the addition of wearable devices.

Methods

Eleven patients who received autologous (n=2) or allogeneic (n=5) HCT or CAR T-cell therapy (n=4) for hematological malignancies were screened from November 2022 to July 2023. Two patients discontinued the study after enrollment. The telehealth platform consisted of the daily collection of vital signs, physical symptoms, and quality of life assessment up to 3 months after hospital discharge. Each patient received a clinically validated smartwatch (ScanWatch) and a digital thermometer, and a dedicated smartphone app was used to collect these data. Daily revision of the data was performed through a web-based platform by a hematologist or a nurse specialized in HCT and CAR T-cell therapy.

Results

Vital signs measured through ScanWatch were successfully collected with medium/high adherence: heart rate was recorded in 8/9 (89%) patients, oxygen saturation and daily steps were recorded in 9/9 (100%) patients, and sleeping hours were recorded in 7/9 (78%) patients. However, temperature recorded manually by the patients was associated with lower compliance, which was recorded in 5/9 (55%) patients. Overall, 5/9 (55%) patients reported clinical symptoms in the app. Quality of life assessment was completed by 8/9 (89%) patients at study enrollment, which decreased to 3/9 (33%) at the end of the third month. Usability was considered acceptable through ratings provided on the System Usability Scale. However, technological issues were reported by the patients.

Conclusions

While the addition of wearable devices to a telehealth clinical platform could have potentially synergic benefits for HCT and CAR T-cell therapy patient monitoring, noncomplete automation of the platform and the absence of a dedicated telemedicine team still represent major limitations to be overcome. This is especially true in our real-life setting where the target population generally comprises patients of older age with a low digital education level.
Optimization of Pengga Reservoir in The Mandalika Special Economic Zone for Irrigation and Water Supply
Authors: Agastya Dewandha , I Wayan Yasa  , I Dewa Gede Jaya Negara
Published: April 2024

Mandalika Special Economic Zone is tourism area that is expected to improve the economy in West Nusa Tenggara Province. To support these activities, an allocation of domestic water needs of 200 liters second -1 is needed. The potential availability of water in the Pengga Reservoir is planned to be a source of domestic water needs in the Mandalika Special Economic Zone. Pengga Reservoir has an effective storage volume of 17.26 MCM. Potential water resources in Pengga Reservoir are obtained from reservoir outflow upstream and lateral inflow from several tributaries. The study was carried out to determine the reservoir storage capacity to meet domestic water needs and irrigation water needs covering an area 3189 ha. The cropping pattern used in the Pengga irrigation area is Paddy – Paddy/Secondary Crops – Paddy/Secondary Crops. To optimize the potential of water resources in the Pengga Reservoir, a linear programming optimization method is used. Indicators of the success of optimization calculations are indicated by the value of cropping intensity, k factor and reliability that have met the minimum limit value. The k factor value for irrigation water needs is 0.70 and domestic water needs is 0.85. Based on the optimization results, it is known the largest annual cropping intensity value occurs in the November I planting season. This conclusion can be seen from the comparison of annual cropping intensity values for the November I and November II planting schedules for the dry year inflow discharge scenario of 99.98% and 97.22% respectively. The cropping intensity value in the November I planting season is greater than November II, namely 100% and 97.25%, for the normal year discharge inflow scenario. This study provides an information for policy makers can use the November I planting schedule to obtain values for maximum cropping intensity and domestic water requirements.
Analysis of Chloride Contaminant Transport in Tailings Storage Facility Dam (Case Study: Gold Mine in Sumatra)
Authors: Pascayulinda Devina , Widjaja Budijanto , Wijaya Martin
Published: April 2024

In the practice of gold mining industry, hazardous waste known as tailings is produced during the ore extraction process. These tailings are typically stored in a dam structure called a Tailings Storage Facility (TSF). The planning and construction of a TSF are critical considerations, as the failure of a TSF can have substantial environmental impacts, pose risks to human safety, and result in industrial losses. Therefore, strict control is necessary in the development of TSFs to minimize the potential negative consequences. This research focuses on the transport of contaminants within a TSF, specifically examining the concentration of chloride contaminants and conducting particle movement analysis. The study utilizes modeling through the GeoStudio SEEP/W program to simulate groundwater flow profiles and the GeoStudio CTRAN/W program to understand contaminant movement over a 100-year period. GeoStudio modeling employs 10 materials: impermeable clay soil, filter sandy soil, transition gravel rock, three mine waste types (Fine, Rockfill, and Rockfill with fine), hard rock bedrock layer, in-situ soil representing the original layer, landslide with colluvial soil, and the tailings itself. Back analysis is employed to iterate model parameters and ensure modeling accuracy against field data, including comparisons with water quality test results and readings from vibrating wire piezometer (VWP) instrumentation. The contaminant transport is influenced by advection-dispersion processes and tends to concentrate within the TSF boundary toward the dam toe over a 100-year timeframe. The analysis emphasizes the influence of advection in contaminant transport and underscores the importance of particle position relative to the groundwater level, with Particle Tracking Analysis shows significant movement within the groundwater flow area. This research provides crucial insights into the dynamics of contaminant concentration, informing better decision-making in TSF planning and management. The findings underscore the imperative of strict control measures to minimize environmental impacts and human safety risks associated with TSFs, thereby advancing knowledge in gold mining waste management.