bluuebunny/crossref_metadata_2025 huggingface dataset:
The Relationship of Activity of Daily Living, Cognition and Anxiety Among the Community Dwelling Elders: A Cross Sectional Study
Authors: Rathod Sahil Sureshbhai , Khristi Siza , Gandhi Mouli
Published: October 2023

ntroduction: Aging affects physiological systems, leading to reduced functional capacity, social isolation, depression, and disability. Musculoskeletal and neurological changes impair daily activities, increasing fall risk and frailty. Cognitive decline impacts thinking, learning, language, and attention, burdening families and society. Anxiety disorders are common, causing mood disturbances and clinical concerns among older adults.
Aims: This study aimed to investigate the relationship between activities of daily living, cognitive functions, and anxiety levels among elderly individuals living in the community, providing valuable insights into their overall well-being and mental health.
Settings and design: Study was carried out among 95 subject’s inclusion criteria was required in this study. Elderly of different age groups (above 65 years of age) of Vadodara city.
Methods and Materials: On the bases of inclusion criteria, a study was carried out among 95 community dwelling elderly of above 65 years age. A cross sectional study is performed for 6 months in Vadodara city of Gujarat.
Statistical analysis used: Data was analyzed by SPSS version 28.0 and Microsoft excel 2019. Data was screened for normal distribution by Shapiro-Wilk test.Demographic data and subjective assessment details was analyzed with the frequency table and pie chart.Outcome measures like KATZ Index, MMSE and GAS-10 by frequency distribution table and charts, and person correlation that was applied to check relationship between KATZ Index, MMSE Scale and GAS-10.
Result: In this study the activity of daily living was evaluated by the KATZ index and cognitive function was assessed by the Mini Mental State Examination (MMSE) and level of anxiety was checked by the Geriatric Anxiety scale-10. Data was analyzed at 5% level of significance with confidence interval (CI) at 95%.
Conclusion: The elderly population with ADL dependency have altered cognitive function and negative relationship between ADLs and anxiety. With impaired ADL function can have low anxiety level. Whereas relationship between cognition and anxiety shows higher cognitive function and low anxiety.

Key words: ADLs, Cognitions, Anxiety, Elderly
An Analysis of the Distribution of Healthcare Facilities, the Population, and the Health Workforce in the Kasaragod District on a Taluk-By-Taluk Basis
Authors: P Sudha , P Angadi Dasharatha
Published: October 2023

Background: The spatial distribution of health care services in the Kasaragod area in relation to the regional population is emphasised in this study. A society's progress towards human development can be seen in the advancement of its improved health care system, educational system, and long-life expectancy. By examining the quantity of healthcare facilities and the healthcare workforce it can be seen that the Kasaragod district's healthcare system has not advanced.
Methods: The approaches utilised here to understand the deficiencies of healthcare in general are Location Quotient, Equal Count, Logarithmic Scale Method, Percentage, etc.
Result: This analysis demonstrates that there are not enough healthcare facilities and health workers in this district depending on the population. The research of the location quotient reveals that the taluks of Vellarikund and Manjeshwaram have fewer medical facilities. But Hosdurg and the Kasaragod taluk have a concentration of healthcare facilities. There are numerous multispecialty hospitals in Mangalore, Karnataka. Manjeshwaram Taluk, which is adjacent, offers subpar medical services.
Conclusion: The entire community in Kasaragod district is pleading with the government for medical development, including the establishment of AIIMS hospital and the prompt completion of the building and operation of the medical college, due to the shortcomings of the healthcare system in this area. The government should grant this community's need for justice and sanction it in order to enhance society. For flourishing the society, the government must grant this community's reasonable needs and acknowledgment.

Key words: spatial distribution, health care facility, Location quotient, Density, Logarithmic scale method.
CytoSorb® in Combination with CRRT in A Patient Suffering from Septic Shock, Acute Respiratory Distress Syndrome (ARDS) and Acute Kidney Injury (AKI): A Case Report
Authors: Sharma Gauri Shankar , Narwal Madhvi
Published: October 2023

OBJECTIVE: We report a case of a patient suffering from septic shock with acute kidney injury (AKI) and acute respiratory distress syndrome (ARDS) treated with standard medical treatment and CRRT, as well as adjuvant extracorporeal hemoadsorption device called CytoSorb® to address the cytokine storm.
CASE PRESENTATION: This case outlines a 53-year-old female patient who was admitted to the hospital with fever and chills, loose stool, vomiting and severe weakness. On admission, she was feverish, hypotensive, with tachycardia, tachypnea, and hypoxic. Vasopressor were started to keep mean arterial pressure (MAP) stable. Chest scan revealed infiltrates, with pleural effusion. she was intubated and placed on mechanical ventilation due to work of breathing (WOB). Later, urine output dropped to anuric levels, followed by acidosis, necessitating the start of Continuous renal replacement therapy (CRRT). Adjuvant CytoSorb® was started due to the condition's deterioration and resistance to therapy.
RESULTS: Post two sessions of CytoSorb®, there was rapid improvement in hemodynamic stability, improvement in respiratory functions, reduction in vasopressors, and decrease in blood lactate.
CONCLUSION: Adjuvant CytoSorb® therapy in conjunction with standard treatment and CRRT was found to be a safe and effective therapeutic alternative in a patient suffering from septic shock, ARDS, and AKI.

Key words: Acute kidney injury, Acute respiratory distress syndrome, CytoSorb, Cytokines, Hemoadsorption, Sepsis, Septic shock
The Sound of Silence: A Study on Tympanic Membrane Perforation and Its Effects on Hearing in Chronic Otitis Media
Authors: B Metgudmath Rajendra , Gulaganji Rahul
Published: October 2023

Introduction: The ear is a sensory organ that picks up sound waves, allowing us to hear. Hearing loss in COM can result from TM perforation. It is generally accepted that severity of hearing loss and site of perforation is connected. Nevertheless, there are several contradictory studies addressing hearing loss related to size and site of TM perforation. Hence, this study is done to correlate the size and site and of TM perforation and to assess impact on the types and degree and of hearing loss in patients with COM.
Objective: The objective of the study was to correlate hearing loss with size and site in TM perforation and to assess its impact with types and degree of hearing loss in patients of COM.
Methods: It was a one-year observational study. The study included a total of 113 ears with TM perforation patients of both sex and between group of 18-60 years. Size of TM perforation was measured using Image J software. Site of TM perforation was assessed using Otoendoscopic examination. Each patient underwent PTA and ENT examination.
Results: Hearing loss was more with increased size of perforation. Hearing loss was comparatively more when perforations were located in the Posterosuperior quadrant. There is a significant association with degree hearing loss and of size of perforation. The degree of hearing loss increases with increased size of the perforation.
Conclusion: Thus, the study shows significant correlation between size and site of TM perforation with the types and degree of hearing loss.

Key words: Size, Site, Tympanic membrane, COM.
Finasteride and Dutasteride for the Treatment of Male Androgenetic Alopecia: A Review of Efficacy and Reproductive Adverse Effects
Authors: Estill Mariah C. , Ford Avery , Omeira Ruba , Rodman Matthew
Published: October 2023

Finasteride and dutasteride are 5-α-reductase inhibitors (5-ARIs) used to treat androgenetic alopecia (AGA). This review evaluates the efficacy of 5-ARIs for treatment of men with AGA and the potential adverse effects on reproduction including sexual dysfunction, infertility, and teratogenicity. A broad literature review was conducted to search for publications on 5-ARI treatment in men with AGA. Hair counts, hair growth assessments, sexual adverse effects (erectile dysfunction, ejaculatory dysfunction, and decreased libido), change in sperm parameters (decreased sperm count, semen volume, sperm motility), and teratogenic drug concentration levels in semen were the measured outcomes of studies included in this literature review. Both finasteride and dutasteride are effective at treating hair loss in male AGA, with studies finding dutasteride was more efficacious than finasteride. Many studies reported sexual adverse effects of 5-ARIs that are uncommon and resolve spontaneously, although there remains no consensus with respect to the presence, severity, and duration of sexual adverse effects. 5-ARIs may have a negative impact on spermatogenesis although the clinical significance of this is unclear and discontinuation of these medications results in improved sperm parameters for most patients. Teratogenicity after paternal exposure is unlikely due to the low concentration of 5-ARIs absorbed in semen. Further research is needed to evaluate the effects of 5-ARI use on reproduction.
Voices on the air: Speech education and campus radio in the postcolonial Philippine university
Authors: Serquiña Oscar Tantoco
Published: October 2023

In the late 1950s and throughout the 1960s, faculty and students of the newly organized Department of Speech and Drama (later Department of Speech Communication and Theatre Arts) at the University of the Philippines (UP) were at the forefront of managing the radio station DZUP, mounting radio productions on campus and shaping the academic curricula for classes in radio speech and writing. These pioneering contributions, though significant, have yet to receive due documentation from communication scholars, researchers, and historians in the country. In this essay, I address this gap by bringing into focus archival documents—photographs, newspaper accounts, official memos, and personal correspondences between academics and administrators—that clarify the academic department’s role in the early systems and operations of DZUP. I argue that these efforts are important because of four main reasons. First, they highlight the often-overlooked relationship between speech education and campus radio in the national university. Second, they emphasize the ways in which the radio booth worked alongside the public speaking platform and the theatre stage as a fundamental space where speech-related pedagogies, performances, and practices played out. Third, they show disciplinary genealogy that links the disciplines of speech communication and mass communication in the University of the Philippines. And finally, they shed light on the pedagogical process involved in teaching, training, and transforming Filipino students into a kind of speaking subjects in the postcolonial Philippines.
Inventory and Spatial Distribution of Invasive Aquatic Plants in the Lower Part of the Nyong River at Lokoundje in the Ocean Department (South-Cameroon)
Authors: R.D. Nwamo , G.P. Ndjouondo , A.E. Essiane Obono , J.J. Tchogom Manga
Published: October 2023

The study, conducted from February to June 2020, presents a specific inventory of aquatic invasive plants and a mapping of their distribution gained from field observations and data collection campaigns on the lower part of the Nyong River. Specifically, it was a question of inventorying plant species and geo-referencing their biotopes. Through the results obtained, 12 taxa of aquatic invasive species are present (10 species upstream, 08 in transition, and 02 downstream). Of the 12 species, 10 have an ornamental mode of introduction and 01 is endemic to the environment. In addition, it also emerges from this study that the spatial distribution of the species of aquatic plants designated in the study area presents clusters mainly around the islets represented and on certain parts of the banks of the river.
Managing Women Empowerment - An Analytical Study on Socioeconomic Conditions of Women Living in Karachi
Authors: Khan Umair , Shah Nasreen Aslam
Published: October 2023

In this research study, an investigation on the socio-economic conditions and historical background of women living in Orangi Town, Karachi, has been chosen, and the purpose of selecting this subject is to get factual information about the lives of women living in this town. The main objective was to scrutinize the actual position of women in socioeconomic contribution and examine their economic status in society. The researcher selected a quantitative research methodology. The research sample consisted of about two hundred (200) women. The researcher used a self-administrative questionnaire to collect data from the respondents. Paid (stitching, embroidery, beauticians, teachers, etc.) and unpaid (homemakers) women were selected as respondents to the research. The study results reveal a strong male-dominant social structure in Orangi town, and women cannot participate in any decision-making activities in public or private spheres of life. The standard education system, patriarchal society, religious misconceptions, the low participation level of women in decision-making, the low level of economic activities, and financial weakness are the main reasons for the decline in the socioeconomic status of women in Orangi town. The researchers suggested that public and private sectors should assist women in small-scale businesses; high-standard educational opportunities because these opportunities increase women's socioeconomic conditions in Orangi town, Karachi.
Influence of the securities market on economic growth
Authors: Litocenco Ana
Published: October 2023

The state securities market represents a reliable source of financing for the economy, which the state can call on, but also can develop, in order to obtain the necessary financial resources for economic development and growth by creating jobs, supporting investment activity, as well as carrying out all actions and measures planned in all spheres of the national economy. At the same time, a developed domestic government securities market can contribute to reducing the state’s dependence on external financial resources, as well as mitigating some of the effects of financial crises. In this context, the purpose of the given article is to analyze the role and influence of the domestic state securities market on the economic growth from a theoretical and practical perspective, being researched based on econometric models, the interdependence between the level and volume of the domestic government securities market of the Republic of Moldova, Brazil, Canada, Romania and Hungary and their economic growth. The results obtained, following the research, show the existence of an interdependence between the analyzed phenomena, the increase in the volume of the domestic securities market generating a certain growth in the economy of that country.
Aspects on the methodology of the attestation, confirmation and recognition of the privileged status of some autochthonous social categories from Bessarabia (1812–1847)
Authors: Frumosu Elena
Published: October 2023

The importance of the multi-aspectual study of the complex political and social processes, which followed after the annexation of Bessarabia to the Russian Empire, derives from the need to establish a concrete model for the incorporation of privileged native social categories into the socio-administrative system of the Russian Empire based on old documents preserved in families. For this reason, approaching the documentary aspect of the process is indispensable and enlightening, contributing to the studies of previous authors. The research undertaken is focused on the typological characterization of the respective documents and on the interdependence between the rights of the autochthonous privileged social categories in Bessarabia and the documentary evidence of their attestation, confirmation and recognition.
Inhabitants of RSSM deported to Siberia and Kazakhstan (June 1940 – July 1941): working conditions and survival
Authors: Zinovii Maria
Published: October 2023

The communist authorities repressed large groups of innocent people, sending them to strenuous physical work in Siberia, without providing them with basic conditions for a decent living, clothing, shoes, necessary work tools. It was only after the collapse of the Soviet Union that historians were able to investigate the horrors of communism. Less has been written about the work and survival conditions from deportation in Romanian historiography from across the Prut River, this study filling some gaps in this regard.
Headquarters of the Academy of Sciences of Moldova – heritage building of national value
Authors: Condraticova Liliana , Ostapov Alina
Published: October 2023

The current headquarters of the Academy of Sciences of Moldova (ASM) was built in the years 1951–1955 according to the project of the renowned architect Valentin Mednec/Mednic and Aleksandr Vedenkin, being a remarkable example of "Stalinist" architecture, characterized by monumentalism, sober aesthetic appearance but also exuberance of decorative elements, perfectly fitted into the urban landscape, including as a starting point for the city's main artery. The present article is a synthesis of archival data that brings to the attention of researchers in the fields of history, architecture, and art the new or less known aspects about the ASM headquarters, as well as arguments in favor of its patrimonial value. The General Assembly of the Academy of Sciences of Moldova from March 22, 2023, unanimously supported the proposal of the general scientific secretary of ASM, dr. hab. Liliana Condraticova, to include this emblematic building from the center of Chisinau into the Register of monuments of the Republic of Moldova protected by the state, approved by the Decision of the Parliament no. 1531 of 1993 (with subsequent additions). There was drawn up a study regarding the history and architectural value of the building, accompanied by unpublished archival images and plans of the building, as well as recent photos, the respective file being submitted for examination to the Ministry of Culture. With the inclusion of the ASM building in the Register of Monuments, the monument classification activities will continue and it will be possible to initiate the inclusion of the entire Ştefan cel Mare şi Sfânt boulevard from Chisinau in the Register of Monuments of the Republic of Moldova thanks to the location of several heritage buildings along the main artery of the city.
Education – a essential premise for a sustainable development
Authors: Ornovetchii Tatiana
Published: October 2023

Education is a fundamental social phenomenon for individual and collective well-being and prosperity. The evolution of this concept over the centuries allowed its transformation into a noble world movement. Today, education is at the center of attention of multiple organizations, unions and summits. Educational policies have become a priority for the European Union, which is working towards the creation of a European Area of education, with the aim of harnessing citizens' knowledge for Europe's prosperity. The continuity of education is one of its most important aspects through which we can create a universal culture of learning. The lifelong education has become an integrative principle for the transformation of any society into an educational fortress, a concept that consists in everyone’s involvement in a continuous educational process.
The Impact of High D-Dimer on The Clinical Outcome of Covid-19 patients at A Private Hospital in Jakarta
Authors: Laila Ramatillah Diana , Ainah Nona , Michael Michael , Kasim Fauzi , Purwati Purwati , Khan Kashifullah
Published: October 2023

D-Dimer is a fibrin degradation product as the resultof thrombus degradation by fibrinolysis. Elevated D-dimer in the blood is a presumptive marker of thrombosis. D-dimer levels above 1g/mL are risk factors for poorprognosis in patients with COVID-19. To evaluate the impact of high D-Dimer on the clinical outcome of Covid-19 patients at Private Hospital in Jakarta. A retrospective cohort study with convenience sampling was applied in this study. There were 980 patients but only 320 patients were eligible for inclusion criteria. This study only included confirmed COVID-19 patients who were hospitalized from March to June 2021, and the study was conducted from March to June 2022. The gender of the majority patients as the sample was male, 165 (52%) and 155(48%) female patients with moderate severity. Correlation between D-dimer and clinical outcome of COVID-19 patients using Fisher's exact method showed a higher survival rate of 287(89.7%) patients compared to 33(10.3%) patients who died with a p-value <0.05. The survival analysis for COVID-19 patients using the Kaplan Meier method showed that patients receiving D-dimer <500ng/mL had a median survival rate of about 90% after approximately 21 days of treatments, whereas patients whowere receiving >500 ng/mL had a 50% survival rate after 30 days of treatment. Patients receiving D-dimer <500ng/mL had a survival rate of about 90% after undergoing treatment for approximately 21 days, while patients who had D-dimer>500 ng/mL had a survival rate of about 50% after 30 days of treatment. Anticoagulants were given to almost all patients, roughly 10 percent died during hospitalization with hypercoagulation complications.
Stability Indicating Bioanalytical Validation of Elexacaftor, Ivacaftor and Tezacaftor using HPLC in Human Plasma
Authors: Marakatham S. , Shanmugapandiyan P.
Published: October 2023

A simple, precised, accurate method was developed for the estimation of Elexacaftor, Ivacaftor and Tezacaftor in human plasma using the Lumacaftor as internal standard by RP-HPLC (Reverse phase-High performance Liquid Chromatographic) technique. Chromatographic conditions used are stationary phase Azilent (250 x 4.6mm, 5m), Mobile phase 0.01N Potassium di-hydrogen phosphate (pH: 3.5) : Acetonitrile in the ratio of 70:30(v/v) and flow rate was maintained at 1.0ml/min, detection wave length was 250nm, column temperature was set to 30oC and diluent was mobile phase Conditions were finalized as optimized method. Retention time of Ivacaftor, Elexacaftor and Tezacaftor were found to be 2.391min, 3.208min and 3.644min. %CV of the Elexacaftor, Ivacaftor and Tezacaftor was found to be 0.08%, 1.05% and 3.59%. %Recovery was obtained as 96.41%, 95.029% and 98.21%. The linearity concentration is in the range of 435-17400ng/mL of Elexacaftor, 60-2400ng/mL of Ivacaftor and 300-1200ng/mL of Tezacaftor (r2 = 0.999) .The lower limits of quantification were 435ng/mL of Elexacaftor, 600ng/mL of Ivacaftor and 300ng/mL of Tezacaftor which reach the level of both drugs possibly found in human plasma. Further, the reported method was validated as per the ICH guidelines and found to be well within the acceptable range. The proposed method is simple, rapid, accurate, precise, and appropriate for pharmacokinetic and therapeutic drug monitoring in the clinical laboratories.
Serahsî’nin Hapis Hayatı İle iİgili Bazı Araştırmalar
Authors: Tashtanova Ayzada
Published: October 2023

Serahsî, h.466/1073 yılında hapse girmiş ve h.480/1087 yılında da özgürlüğüne kavuşmuştur. Bu 14 sene içerisinde Şemsü’l-Mülk II Nasr b. İbrahim (1068-1079), Ebû Şûca Hızır Han (1079-1080) ve Ahmed Han (1081-1088) olmak üzere üç hakan tahta gelmiştir. Bu üç hakanın dönem dönem fukaha ile anlaşmazlıkları olmuş, hatta bazı fakihleri idam ettirene kadar varılmıştır. Imam Serahsî’nin de bu fakihler arasında yer aldığını tahmin etmek mümkün. Tabakât eserlerinde, İmam Serahsî’nin hapse atılmasının nedeni ile ilgili, dönemin emîrine, hakanına “nasihat içeren bir sözü” sarfetmiş olduğundan dolayı hapsedildiği haberi yer alır. Kendisi ise el-Mebsut’un 19 yerinde, Usulü’l-Fıkh’ın 1 yerinde, Şerhu Siyeri’l- Kebîr’in 1 yerinde olmak üzere toplam 23 pasajda, hapis hayatından, o günlerin zorluklarından ve hapse düşüren sebepten bahsetmiştir.
Кыргызстанда дин сабагынын окутуунун негиздери жана дин сабагын окутууда дүйнөдө колдонулган моделдер
Authors: Жумабаев Максат
Published: October 2023

Бул макалада, акыркы мезгилде Кыргызстанда «дин сабагын» тактап айтканда “Дин маданиятынын тарыхы” предметин мектептерде окутуу боюнча коомчулукта айтылып келе жаткан ар кандай сунуш жана демилгелер талкууга алынат. Динди окутуу боюнча  дүйнөлүк практикада колдонулган моделдер, дин таануу предметинин негиздери менен салыштырылып, учурда окутулуп жаткан предмет менен канчалык денгээлде айкалыша тургандыгы изилденет.
Bibliometric Analysis of Higher Education Restructuring
Authors: YÜCEL Fatma Hümeyra , KUZU Yasemin
Published: October 2023

The spread of competitive elements and the well-being of human capital increase productivity capacities in scientific content. Research and development activities are prioritized in higher education, international trends and modern paradigms are taken into consideration. In the study, a visual map of the studies prepared on the restructuring of higher education on a global scale was prepared and it was aimed to determine the trends in the literature with bibliometric analysis. Between 2002 and 2022, a total of 585 articles in the Scopus and WoS database were identified and analyzed by keyword analysis, cooperation network analysis, social network analysis methods. The most commonly used keywords were "higher education, education, university, restructuring and neoliberalism", the largest clusters defined in the network were "higher education, humanities, education policy", and the smallest cluster was "higher education policy". Among these clusters, the largest cluster is the "higher education" cluster, the average year of the publications cited jointly is 2011, and the newest issues are "humanities and higher education policy". According to the timeline map, there was a focus on the keywords "higher education, curriculum, neoliberalism, China, student, administration". In the early days, the focus was on "higher education, curriculum", then "higher education policy, innovation, management, organizational change, university reform, savings", and after 2020, the keywords "Covid 19, pandemic, distance education, student". The keywords with the most citation explosions were initially "Eurasia", in the middle "management, higher education, student", and after 2020, "student, Covid 19, human". The highest explosion of citations occurred from the word "Eurasia" between 2005 and 2009.
Examination of Sports Self-Regulation, Motivational Determination, and Decision-Making Styles in University Students
Authors: AYDOĞAN Rukiye
Published: October 2023

The aim of this research is to examine the sports self-regulation skills and decision-making skills of students studying at sports science faculties. The study was carried out with a sample group of 224 volunteer participants from Aydın Adnan Menderes University Faculty of Sports Sciences. 35.7% (n=80) of the participants were women and 64.3% (n=144) were men. In the study, it was collected with the "Sports Self-Regulation Scale" to measure sports self-regulation skills, the "Motivational Determination Scale" and the "Rational and Decision-Making Styles Scale" to measure decision-making skills. In the analysis of the data, mean, standard deviation, minimum-maximum-median were calculated from descriptive statistics. Mann Whitney U was used in intergroup comparisons and Spearman Correlation analysis was used to examine the relationships between variables. Linear regression analysis was performed with the variables found significant in univariate analyses. According to the results obtained, students' sports self-regulation skills predict their motivational determination. Again, students' sports self-regulation skills predict both rational decision-making and intuitive decision-making styles. While women have a more intuitive decision-making style than men, men have a more rational decision-making style than women. According to the data obtained in the research, it is recommended that self-regulation trainings should be conducted to improve students' decision-making skills.
Diagnosis pada Benign Paroxysmal Positional Vertigo (BPPV)
Authors: Tobing Darryl Jessica , Ratna Maya Ganda
Published: October 2023

Benign Paroxysmal Positional Vertigo (BPPV) adalah sebuah kelainan yang dicirikan dengan vertigo berulang yang diakibatkan perubahan posisi kepala seperti melihat ke atas, mengganti posisi saat berbaring, atau saat mencoba meluruskan posisi tubuh setelah membungkuk. Vertigo menyebabkan adanya kelainan persepsi dan menimbulkan perasaan pusing ringan hingga mual muntah yang menggangg kehidupan sehari-hari. Sumber yang digunakan meliputi 14 artikel yang didapat dari PubMed NCBI dan OJS Universitas Udayana dan 4 buku online dalam rentang publikai tahun 2003-2021.  Sumber bacaan yang digunakan kemudian dianalisis dengan metode systematic literature review yang meliputi aktivitas pengumpulan, evaluasi, dan pengembangan penelitian dengan fokus tertentu. Diagnosis pada BPPV dapat dilakukan dengan anamnesis dan manuver tertentu. Manuver Dix-Hallpike dan Supine Head Roll menjadi  pilihan untuk membantu mendiagnosis BPPV.  Manuver Dix-Hallpike termodifikasi dapat membantu diagnosis BPPV kanal multipel yang sulit untuk dinilai dengan manuver klasik Dix-Hallpike
management of hypertension
Authors: Setia Aldi , Nusadewiarti Azelia
Published: October 2023

Hipertensi adalah meningkatnya tekanan darah sistolik lebih besar dari 140 mmHg dan atau diastolik lebih besar dari 90 mmHg pada dua kali pengukuran dengan selang waktu 5 menit dalam keadaan cukup istirahat (tenang). Beberapa faktor resiko yang berperan dalam peningkatan angka kejadian hipertensi adalah umur, jenis kelamin, riwayat keluarga, genetik, kebiasaan merokok, konsumsi garam, konsumsi lemak jenuh, penggunaan jelantah, kebiasaan konsumsi minum-minuman beralkohol, obesitas, kurang aktifitas fisik, stres, kurangnya pengetahuan terhadap penyakit hipertensi, penggunaan estrogen. Studi ini merupakan laporan kasus berbasis Evidence Base Medicine pada pasien wanita usia 71 tahun dengan mengidentifikasi faktor resiko dan masalah klinis serta penatalaksanaan pasien berdasarkan masalah pasien serta pendekatan patient centred dan family approach. Data primer diperoleh melalui anamnesis (autoanamnesis), pemeriksaan fisik dan kunjungan ke rumah. Data sekunder didapat dari rekam medis pasien. Penilaian berdasarkan diagnosis holistik dari awal, proses, dan akhir studi secara kualitiatif dan kuantitatif. Pasien Ny.S usia 71 tahun di diagnosa dengan hipertensi dan gout atritis, memiliki aspek resiko internal berupa obesitas, Pengetahuan yang kurang tentang penyebab, komplikasi serta pengobatan pada penyakit hipertensi dan gout athritis. Pengetahuan yang kurang mengenai pentingnya aktivitas fisik dan pola makan yang baik sesuai kebutuhan serta konsumsi obat rutin. Aspek resiko eksternal berupa psikososial keluarga pasien yang kurang memahami mengenai penyakit pasien, sosial ekonomi yang kurang. Penatalaksanaan secara holistik dengan pendekatan dokter keluarga dapat meningkatkan pengetahuan ,sikap ,dan perilaku pada pasien. Selain itu, peran keluarga amat penting dalam perawatan dan pengobatan anggota keluarga yang sakit.
HUBUNGAN ANTARA VOLUME SPESIMEN TUR PROSTAT DENGAN USIA DI RUMAH SAKIT PERTAMINA BINTANG AMIN BANDAR LAMPUNG TAHUN 2020 DAN 2021
Authors: Prasetio Iradah Lia , Musthofa Festy Ladyani , Purnanto Eko
Published: October 2023

Latar Belakang. Benign Prostatic Hyperplasia (BPH) merupakan gangguan yang terjadi pada kelenjar prostat. Di Indonesia, BPH merupakan penyakit yang menempati urutan kedua setelah batu saluran kemih.

Tujuan. Menganalisis hubungan antara volume spesimen TUR prostat dengan usia di Rumah Sakit Pertamina Bintang Amin Bandar Lampung tahun 2020 dan 2021.

Metode. Jenis penelitian, analitik kuantitatif. Teknik pengumpulan data, dokumentasi rekam medik. Dari 262 pasien BPH dengan TUR, ada 219 data yang memenuhi kriteria inklusi dan ekslusi. Setelah Penarikan sampel dilakukan dengan menggunakan proporsional simple random sampling, didapatkan sampel 141 orang. Data dianalisis dengan uji Spearman’s rho.

Hasil. Berdasarkan hasil penelitian, usia pasien BPH termuda 47 tahun, tertua 91 tahun. Usia terbanyak >60 tahun (79,4%). Volume spesimen prostat terbanyak berukuran >10 cm (53,2%).

Kesimpulan. Terdapat hubungan yang signifikan antara volume spesimen TUR prostat dengan usia (p=0,018). Semakin tinggi usia maka akan semakin besar volume prostat (r=0,199).
Tatalaksana Frozen Shoulder
Authors: Fitriyana Intan , Ismunandar Helmi , Wintoko Risal , Hadibrata Exsa , Djausal Anisa Nuraisa
Published: October 2023

Frozen shoulder (Adhesive capsulitis) merupakan penyakit yang di tandai dengan penurunan Range Of Motion (ROM) baik secara aktif ataupun pasif pada sendi glenohumeral yang di sertai dengan rasa sakit. Frozen shoulder diklasifikasikan menjadi primer dan sekunder. Frozen shoulder memiliki 3 fase yaitu freezing (painful), frozen (adhesive) dan Resolusi. Pasien dengan frozen shoulder biasanya mengalami kekakuan bahu, nyeri hebat biasanya memburuk pada malam hari, dan hilangnya rotasi eksternal pasif dan aktif bahu. Tujuan  penulisan  ini  untuk mengetahui  tatalaksana pada pasien frozen shoulder.  Metode  yang  digunakan  adalah literature  riview dengan  mencari  frozen shoulder, adhesive capsulitis, management, treatment di  Google  Scholar  dan  Pubmed.  Pencarian  literatur  baik  dari  jurnal  nasional  maupun internasional  kemudian  merangkum  topik  pembahasan  dan  membandingkan  hasil  yang  disajikan  dalam  artikel.  Dari tinjauan  yang  telah  dilakukan  didapatkan tatalaksana pada pasien frozen shouder terbagi menjadi tatalaksana konservatif (Non-operatif) dan tatalaksana Operative. tatalaksana konservatif termasuk farmakoterapi, fisioterapi, dan hidrodilatasi. Tatalaksana operative termasuk  manipulation under anesthesia dan arthroscopic capsular release. Tatalaksana farmakoterapi dapat menggunakan NSID, steroid oral dan steroid injeksi. Fisioterapi baik untuk meningkatkan ROM pada pasien frozen shoulder, namun fisioterapi biasanya di kombinasikan dengan beberapa terapi lain. Hidrodilatasi adalah intervensi radiologi non-bedah yang manfaat terbesarnya dirasakan 3 bulan setelah intervensi. Manipulation under anesthesia dan arthroscopic capsular release adalah tatalaksana operative yang memberikan peningkatan ROM dan pengurangan rasa nyeri.
Efek Pemberian Ginkgo Biloba Terhadap Pasien Generalized Anxiety Disorder
Authors: Azzahra Natasya Jasmine , Oktarlina Rasmi Zakiah
Published: October 2023

Generalized anxiety disorders (GAD) adalah gangguan kecemasan yang ditandai dengan perasaan cemas yang umum dan cemas bahwa sesuatu yang buruk akan terjadi. Tanda-tanda seseorang menderita GAD yaitu adanya perasaan cemas yang persisten yang tidak dipicu oleh suatu objek, situasi, atau aktivitas tertentu, keadaan ini lebih bersifat free floating. Di indonesia terdapat sebanyak 14 juta penduduk mengalami gangguan mental emosional termasuk gangguan kecemasan. Tatalaksana farmakologi yang menjadi pilihan utama dalam penatalaksanaan GAD yaitu benzodiazepin. Namun penggunaan benzodiazepin terkadang menyebabkan beberapa masalah seperti toleransi, ketergantungan, serta gangguan kesadaran. Ginkgo biloba merupakan tanaman yang sejak zaman dahulu digunakan untuk kepentingan pengobatan. Ginkgo biloba memiliki kemampuan untuk mengurangi gejala pada gangguan cemas. Beberapa penelitian menunjukkan bahwa ekstrak ginkgo biloba memiliki efek yang sebanding dengan obat antidepresan modern. Penggunaan ginkgo biloba juga tidak menunjukkan adanya efek ansiolitik kuat baik dalam penggunaan jangka pendek maupun jangka panjang. Mekanisme ginkgo biloba dalam mengurangi gejala gangguan cemas yaitu menekan CRH, menurunkan kadar serotonin dan dopamin, serta manfaat antioksidan.
Faktor Resiko Osteoarthritis
Authors: Swastini Ni Putu , Ismunandar Helmi , Wintoko Risal , Hadibrata Exsa , Djausal Anisa Nuraisa
Published: October 2023

Osteoarthritis (OA) merupakan penyakit sendi degeneratif yang prevalensinya meningkat seiring dengan bertambahnya usia dan menyebabkan penurunan fungsional serta penurunan kualitas hidup pasien. Gejala klinis OA yaitu kekakuan sendi, nyeri sendi dan disfungsi sendi, namun masalah utama bagi sebagian besar pasien adalah rasa sakit atau nyeri pada sendi. Gejala tersebut akan menurunkan kulitas hidup pasien yang menderita osteoarthritis. Penyebab pasti dari OA tidak diketahui. Sejumlah penelitian yang ada saat ini, menyebutkan bahwa penyebab osteoarthritis adalah multifaktorial. Tujuan dari penelitian ini adalah untuk mengetahui faktor resiko dari osteoarthritis. Metode  yang  digunakan  adalah literature riview dengan  mencari  osteoarhtritis, risk factor, determinant di  Google  Scholar  dan  Pubmed.  Pencarian  literatur  baik  dari  jurnal  nasional  maupun internasional  kemudian  merangkum  topik  pembahasan  dan  membandingkan  hasil  yang  disajikan  dalam  artikel.  Dari tinjauan  yang  telah  dilakukan  didapatkan faktor resiko osteoarthritis dibagi menjadi dua yaitu faktor sistemik dan faktor local. Faktor sistemik dari OA adalah usia, jenis kelamin, etnis, genetik, dan diet.Osteoarthritis sering ditemmui pada wanita di atas 50 tahun. Beberapa penelitian telah menganalisis hubungan osteoarthritis dengan beberapa gen. selain itu, etnis minoritas biasanya mengembangkan gejala yang lebih buruk. Diet seperti Vitamin D, glukosamin dan kondroitin sulfat juga dapat menjadi faktor resiko osteoarthritis. Faktor lokal dari OA adalah obesitas, trauma, dan okupasi juga telah diteliti sebagai faktor resiko osteoarthritis.
PENGARUH EKSTRAK BAWANG PUTIH (Allium sativum) TERHADAP MORFOLOGI MIOKARDIUM PADA TIKUS PUTIH (Rattus norvegicus) GALUR SPRAGUE DAWLEY YANG DIINDUKSI STREPTOZOTOCIN
Authors: Hasna Afina , Susianti Susianti , Fiana Dewi Nur
Published: October 2023

Latar Belakang: Diabetes Melitus (DM) merupakan penyakit metabolik dengan angka prevalensi yang tinggi dan menyebabkan komplikasi pada berbagai organ.  Streptozotocin (STZ) merupakan agen diabetogenik yang sering digunakan untuk menginduksi diabetes melitus pada hewan uji. Bawang putih memiliki kandungan allicin yang berperan sebagai antidiabetik. Selain itu, bawang putih juga berpotensi sebagai antioksidan dan antiinflamasi yang dapat mengurangi kerusakan oksidatif akibat diabetes melitus. Penelitian ini bertujuan untuk mengetahui apakah terdapat pengaruh ekstrak bawang putih (Allium sativum) terhadap morfologi miokardium tikus putih yang diinduksi streptozotocin. Metode: Penelitian ini merupakan penelitian eksperimental dengan metode Post Test Only Control Group Design. Sampel berjumlah 24 ekor tikus putih yang dibagi secara acak ke dalam 4 kelompok, yaitu KN (diet standar), K- (STZ 60mg/kgBB), P1 (STZ 60 mg/kgBB + Ekstrak bawang putih 500 mg/kgBB), P2 (STZ 60 mg/kgBB + Ekstrak bawang putih 750 mg/kgBB). Gambaran histopatologi miokardium jantung dinilai dengan menggunakan kriteria Dallas. Hasil: Penelitian menunjukkan bahwa skor kerusakan jantung terendah terdapat pada kelompok KN, sedangkan skor terbesar pada kelompok K-. Skor kerusakan miokardium menurun pada kelompok P1 dan P2. Hasil Uji Kruskal-Wallis menunjukkan terdapat perbedaan yang bermakna secara statistik pada kelompok uji dengan nilai p sebesar 0.000 (p<0.05). Hasil Uji Post Hoc Mann-Whitney menunjukkan perbedaan yang signifikan di antara semua pasangan kelompok, kecuali antara kelompok P1 dan P2 yang memiliki nilai signifikansi 0.545 (p>0.05). Simpulan: Terdapat pengaruh pemberian ekstrak bawang putih (Allium sativum) terhadap morfologi miokardium jantung tikus putih (Rattus norvegicus) galur Sprague dawley yang diinduksi streptozotocin.
Gambaran Kondisi Psikologis Mahasiswa Fakultas Kedokteran Selama Pembelajaran Daring di Era Pandemi Covid-19
Authors: Prameswari Dyah Cahya , Oktafany Oktafany , Carolia Novita , Saputra Oktadoni
Published: October 2023

Pandemi Covid-19 mengharuskan pemerintah menerapkan kebijakan pembelajaran daring untuk memutus rantai penyebaran virus. Penerapan pembelajaran daring dinilai kurang efektif dilakukan pada mahasiswa karena tidak ada interaksi dan kurangnya keterampilan yang diperoleh. Perubahan sistem pembelajaran dan keadaan pandemi Covid-19 memaksa mahasiswa harus beradaptasi dengan sistem pembelajaran baru yang dapat menyebabkan mahasiswa memiliki masalah psikologis, yang jika tidak dideteksi dan diatasi sejak dini gangguan tersebut dapat menetap. Penelitian ini bertujuan untuk mengetahui gambaran kondisi psikologis mahasiswa Fakultas Kedokteran Universitas Lampung selama pembelajaran daring di era pandemi Covid-19. Desain penelitian ini menggunakan metode deskriptif kuantitatif dengan pendekatan survei pada 338 sampel terpilih dengan teknik total sampling pada 4 angkatan aktif mahasiswa. Data dikumpulkan dengan pengisian Self-Reporting Questionnaire (SRQ-20) yang dikembangkan oleh WHO dan telah diadopsi oleh Kemenkes RI. Hasil penelitian ini menunjukkan bahawa mahasiswa yang terindikasi masalah psikologis selama pembelajaran daring di era pandemi Covid-19 sebesar 56,8% dan yang tidak terindikasi masalah psikologis sebesar 43,2%. Masalah psikologis yang dialami yaitu gejala penurunan energi, gejala depresi, gejala cemas, gejala kognitif dan gejala somatik. Pada penelitian ini sebagian besar mahasiswa kedokteran terindikasi masalah psikologis selama pembelajaran daring di era pandemic Covid-19 dan perlu mendapatkan perhatian untuk diselesaikan.
Hubungan Efikasi Diri Terhadap Tingkat Stres dan Ansietas pada Mahasiswa yang Sedang Menyelesaikan Tugas Akhir Program Studi Pendidikan Dokter Universitas Lampung
Authors: Martogi Simalango Eka Yuliana , Oktafany Oktafany , Djausal Anisa Nuraisa , Berawi Khairun Nisa
Published: October 2023

Skripsi merupakan salah satu persyaratan yang wajib diselesaikan oleh mahasiswa tingkat akhir. Penulisan skripsi menuntut mahasiswa untuk berpikir lebih keras dan dapat menimbulkan stress maupun kecemasan. Dalam mengatasi hal tersebut mahasiswa efikasi diri. Penelitian ini bertujuan mengetahui hubungan efikasi diri terhadap tingkat stres dan ansietas pada mahasiswa yang sedang menyelesaikan tugas akhir Program Studi Pendidikan Dokter Universitas Lampung. Desain penelitian ini menggunakan metode analitik observasional dengan pendekatan cross sectional. Responden terdiri dari 180 mahasiswa  dengan menggunakan teknik total sampling. Penelitian ini menggunakan data primer berupa kuesioner. Analisis yang digunakan adalah Kruskall-Wallis. Hasil penelitian menunjukkan terdapat 109 mahasiswa (60,6%) mengalami stres sedang dan 56 mahasiswa (31,1%) mengalami ansietas ringan. Hasil penelitian menunjukkan terdapat hubungan yang signifikan antara efikasi diri dengan tingkat stres (p-value 0,006) dan terdapat hubungan efikasi diri dengan tingkat ansietas (p-value 0,001).
Diagnosis dan Tatalaksana Kolelitiasis
Authors: Adhata Attara Rafilia , Mustofa Syazili , Soleha Tri Umiana
Published: October 2023

Kolelitiasis (batu empedu) adalah kristal yang dapat ditemukan di dalam kandung empedu, saluran empedu, atau keduanya. Batu empedu terbagi menjadi tiga jenis yaitu batu kolestrol, batu pigmen (batu bilirubin), dan batu campuran. Batu pigmen terbagi menjadi pigmen coklat dan pigmen hitam, dan batu kolestrol adalah jenis yang paling sering dijumpai. Kolelitiasis jarang terjadi pada anak-anak namun sebagian besar kasus kolelitiasis pada anak dihubungkan dengan beberapa faktor yaitu penyakit hemolitik, riwayat terapi dengan Total Parenteral Nutrition (TPN), wilson’s disease, kistik fibrosi, dan penggunaan beberapa jenis obat-obatan. Faktor risiko kolelitiasis adalah usia >40 tahun, jenis kelamin perempuan, berat badan berlebih, sering mengkonsumsi makanan tinggi lemak, aktivitas fisik kurang, dan nutrisi intra-vena jangka lama. Kolelitiasis bisa muncul dengan atau tanpa gejala, gejala klinis yang umumnya muncul adalah nyeri kolik bilier yang berlangsung lebih dari 15 menit. Progresifitas kolelitiasis menjadi bergejala cenderung rendah sekitar 10-25%. Kolelitiasis biasanya ditemukan secara tidak sengaja saat melakukan pemeriksaan USG (Ultrasonografi) abdomen. Pemeriksaan penunjang kolelitiasis adalah pemeriksaan laboratorium, pemeriksaan foto polos abdomen, ultrasonografi, pemeriksaan kolisistografi oral, dan pemeriksaan sonogram. Penatalaksanaan non bedah kolelitiasis dapat berupa penatalaksanaan pendukung dan diet, oral dissolution therapy, disolusi kontak, dan Extracorporeal Shock Wave Lithotripsy (ESWL). Penatalaksanaan bedah terdiri dari kolisistektomi terbuka dan kolisistektomi laparoskopi. Baku emas penatalaksanaan kolelitiasis dengan gejala adalah kolisistektomi.
Pengaruh Pemberian Injeksi Intramuskular Sel Punca Mesenkimal Tali Pusat Manusia terhadap Gambaran Histopatologi Hati Tikus Putih (Rattus Norvegicus) yang Diinduksi Aspirin
Authors: Wardoyo Asyraf Vivaldi , Kurniawati Evi , Susianti Susianti , Busman Hendri
Published: October 2023

Penggunaan aspirin secara berlebihan dan tidak terkontrol  dapat menyebabkan beberapa komplikasi dan berbagai kerusakan pada organ, termasuk kerusakan pada organ hati. Sel punca mesenkimal tali pusat manusia merupakan salah satu sumber untuk regenerasi dan perbaikan jaringan yang rusak. Penelitian ini bertujuan untuk membuktikan pengaruh pemberian injeksi intramuskular sel punca mesenkimal tali pusat manusia terhadap gambaran histopatologi hati tikus putih (Rattus Norvegicus)  galur Sprague Dawley yang diinduksi aspirin. Penelitian ini merupakan penelitian eksperimental dengan desain post-test only control group design dengan 27 ekor tikus putih (Rattus norvegicus) galur Sprague dawley yang dibagi menjadi tiga kelompok perlakuan. Kelompok kontrol (K) diberi makanan dan minuman standar selama 42 hari, P1 diberi aspirin 200 mg / kgBB dengan pemberian secara oral selama 14 hari, P2 diberi aspirin 200 mg / kgBB secara oral selama 14 hari dan diberikan injeksi sel punca mesenkimal tali pusat manusia secara intramuskular 0,75 mL pada hari ke-14 dan ke-28. Setelah data hasil penelitian didapatkan, data diamati dengan Uji Non-Parametrik Kruskal-Wallis, diperoleh p = 0,000 (p <0,05). Hasil yang diharapkan diperoleh Ho yang diharapkan. Hasil statistik dengan uji Mann-Whitney yang diperoleh juga ditemukan adanya perbedaan yang signifikan pada setiap kelompok, tetapi P1 dengan P2 (p= 0,199 ) tidak memperoleh perbedaan yang signifikan.Kesimpulan yang didapatkan adalah Terdapat pengaruh pemberian injeksi intramuskular sel punca mesenkimal tali pusat manusia terhadap gambaran histopatologi hati tikus putih (Rattus Norvegicus)  galur Sprague Dawley yang diinduksi aspirin.
Manajemen Anestesi pada Pasien Meningioma Tuberculum Sellae : Sebuah Laporan Kasus
Authors: Edi Dhea Oksala , Wahyuni Ari
Published: October 2023

Meningioma tubercullum sellae merupakan salah satu meningioma intrakranial yang terletak pada daerah limbus sphenoidale, sulcus chiasmaticus dan diaphragma. Gejala dan tanda umum pada meningioma dapat berupa asimtomatis, peningkatan tekanan intrakranial atau timbul akibat kompresi atau destruksi struktur otak yakni berupa defisit neurologis. Diagnosis berdasarkan anamnesis, pemeriksaan klinis dan penunjang radiologis serta histopatologis. Modalitas terapi meningioma meliputi medikamentosa,pembedahan dan radioterapi. Pasien laki-laki berusia 53 tahun, dengan berat badan 70 kg dan tinggi badan 165 cm. Pasien diantar oleh keluarga datang ke instalasi gawat darurat dengan keluhan nyeri kepala sejak 6 bulan yang lalu dan semakin memberat sejak 2 minggu sebelum masuk rumah sakit disertai lemah pada tungkai kaki sehingga pasien tidak dapat berjalan. Riwayat alergi obat dan makanan tidak ada. Riwayat operasi dan pengobatan sebelumnya tidak ada. Pasien dilakukan pembedahan kraniotomi dengan beberapa pertimbangan anestesi sebelumnya. Manajemen anestesi preoperatif, intraoperatif dan pascaoperatif yang lengkap dapat memperbaiki outcome pasien sehingga keberhasilan operasi menjadi lebih baik.