bluuebunny/crossref_metadata_2025 huggingface dataset:
Lower gastrointestinal bleeding due to pancreatic cancer: an unusual presentation
Authors: Larrosa Camila , Moratorio Ignacio , Canavesi Adrián
Published: October 2023

Pancreatic cancer is a malignant neoplasm with a poor prognosis. When it manifests clinically with cold jaundice, general repercussion or dyspepsia, it usually corresponds to a locally advanced tumor. Enterorrhagia as a form of presentation of pancreatic cancer is extremely infrequent; it corresponds to a severe form with an ominous prognosis. We present the case of a 61-year-old man who attended emergency service for enterorrhagia associated with organic abdominal pain and general repercussions, to whom a diagnosis of pancreatic tail cancer was diagnosed. Colonoscopy revealed mucosal infiltration with intense edema, erythema, necrosis, and spontaneous bleeding at the level of the splenic flexure of the colon. Histology confirmed colonic infiltration by pancreatic neoplasm. Computed tomography allowed staging in stage IV. Palliative surgical treatment was performed, with a survival of 3 months.
Alat Bantu Jalan Tunanetra menggunakan Sensor Ultrasonik
Authors: Chandra Harits , Pratama Firman
Published: October 2023

Abstract— Penelitian ini bertujuan untuk mengembangkan alat bantu jalan tunanetra menggunakan sensor ultrasonik berbasis Arduino. Alat ini dirancang untuk membantu mobilitas tunanetra dalam menjalankan aktivitas sehari-hari dan meningkatkan kewaspadaan terhadap halangan atau benda di depan. Penelitian ini menggunakan metode studi literatur, observasi, dan Rapid Application Development (RAD) dalam pengembangan sistem. Sistem ini menggunakan sensor ultrasonik untuk mendeteksi benda atau halangan yang memantulkan gelombang ultrasonik, dan dilengkapi dengan buzzer yang berbunyi sebagai tanda peringatan. Metode logika fuzzy Mamdani untuk mengontrol intensitas bunyi buzzer berdasarkan jarak yang terdeteksi oleh sensor ultrasonik memiliki potensi untuk meningkatkan akurasi dalam memberikan informasi tentang keberadaan hambatan atau halangan bagi pengguna alat bantu jalan tunanetra.

Keywords — Alat bantu jalan tunanetra, Sensor ultrasonic, Arduino, Fuzzy
Unravelling the Depths of Sanatana Dharma: Exploring the Eternal Principles of Hinduism
Authors: Srinivasan Ramanathan , Aithal P. S.
Published: October 2023

Purpose: Sanatana Dharma, also known as Hinduism is an ancient cultural tradition that originated in India. It encompasses a range of beliefs, practices, and philosophies that emphasise concepts, like karma, dharma, and moksha. Hinduism is one of the most revered religions in the world.
Methodology: This study aims to explore the tapestry of Hinduism uncovering the timeless principles that have guided its followers for thousands of years. It will delve into the aspects of Hinduism including its deities and sacred texts as well as its vibrant traditions and rituals.
Result/Analysis: This exploration will shed light on the philosophical and ethical dimensions that form the foundation of this faith.
Originality/Value: By analysing the core principles of Sanatana Dharma this paper seeks to offer an understanding of the wisdom embodied by Hinduism while fostering cross-cultural dialogue and appreciation, for this enduring spiritual tradition.
Type of Paper: Exploratory.
Psilocybin, Depression, and Synaptogenesis: Insights into the Field’s Past, Present, and Future
Authors: Douglas Anna , Staas Daniel , Hampton Anna , Burns Kylie , Suter Fenn
Published: October 2023

Depression remains one the most commonly diagnosed mental health disorders in the United States. The Food and Drug Administration granted psilocybin breakthrough therapy status four years ago as a possible solution to this pervasive disorder. Since then, psilocybin, and hallucinogens in general, have produced promising results as alternatives to classical antidepressants. As more research confirms psilocybin’s potential therapeutic effect, research surrounding the mechanistic action of these 5-HT2A receptor agonists has increased as well. Hallucinogens have different downstream effects compared to non-hallucinogenic 5-HT2A receptor agonists, including the formation of a 5-HT2A receptor and metabotropic glutamate receptor complex. Psilocybin’s unique synaptogenic effect may play a role in its therapeutic effect for major depressive disorder; however, the underlying mechanism by which synaptogenesis is induced upon psilocybin administration has not been explored. Psilocybin’s distinctive upregulation of transcription factors, such as egr-2, c-fos, and brain-derived neurotrophic factors, and its connection with the TrkB signaling pathway, may be the answer to this unexplained mechanism.
WRITING A THESIS IN A PANDEMIC: THE CASE OF SPECIAL EDUCATION
Authors: UÇAR Ahmet Serhat
Published: October 2023

In this study, it was aimed to determine the effects of Covid-129 pandemic on the thesis writing processes of academicians working in the field of special education. The research was conducted with a phenomenological approach from qualitative research methods. Purposive sampling was used to determine the participants in the study. The participants of the study were 11 research assistants who completed their doctoral studies in the Department of Special Education. Research data were collected through semi-structured interviews and researcher's diary. The data obtained were analyzed using content analysis and eight themes were reached. The themes are; I should continue with this topic, I insisted on my method, I had difficulty finding participants, how was my data collection process affected, how was my reporting phase, what did my advisor do, how did other factors affect my research, and if the pandemic happens again. The Covid-19 pandemic has caused significant disruptions in academic studies as in every field. Academics tried to eliminate the problems they experienced with distance education platforms and individual solutions and to complete the process with minimal disruption. It is recommended that studies be conducted to identify, implement and disseminate methods that can be used to overcome similar processes more easily in future research.
Language Teacher Wellbeing across the Career Span
Authors: YÜZLÜ Muhammet Yaşar
Published: October 2023

Teacher wellbeing is gaining prominence in the realm of educational psychology, although it remains a relatively nascent domain. This trend is propelled by a perceptible shift in research focus, transitioning from an overwhelming emphasis on student-centered paradigms to a recognition of the indispensability of catering to teacher-centric considerations. This shift in emphasis underscores the evolving dynamics. Within this milieu, the domain of language teacher wellbeing emerges as a pivotal locus of inquiry within the broader landscape of language teacher psychology.
Sub-cloud rain evaporation in the North Atlantic winter trade winds derived by pairing isotopic data with a bin-resolved microphysical model
Authors: Sarkar Mampi , Bailey Adriana , Blossey Peter , de Szoeke Simon P. , Noone David , Quiñones Meléndez Estefanía , Leandro Mason D. , Chuang Patrick Y.
Published: October 2023

Abstract. Sub-cloud rain evaporation in the trade wind region significantly influences the boundary layer mass and energy budgets. Parameterizing it is, however, difficult due to the sparsity of well-resolved rain observations and the challenges of sampling short-lived marine cumulus clouds. In this study, sub-cloud rain evaporation is analyzed using a steady-state, one-dimensional model that simulates changes in drop sizes, relative humidity, and rain isotopic composition. The model is initialized with relative humidity, raindrop size distributions, and water vapor isotope ratios (e.g., δDv, δ18Ov) sampled by the NOAA P3 aircraft during the Atlantic Tradewind Ocean–Atmosphere Mesoscale Interaction Campaign (ATOMIC), which was part of the larger EUREC4A (ElUcidating the RolE of Clouds–Circulation Coupling in ClimAte) field program. The modeled surface precipitation isotope ratios closely match the observations from EUREC4A ground-based and ship-based platforms, lending credibility to our model. The model suggests that 63 % of the rain mass evaporates in the sub-cloud layer across 22 P3 cases. The vertical distribution of the evaporated rain flux is top heavy for a narrow (σ) raindrop size distribution (RSD) centered over a small geometric mean diameter (Dg) at the cloud base. A top-heavy profile has a higher rain-evaporated fraction (REF) and larger changes in the rain deuterium excess (d=δD-8×δ18O) between the cloud base and the surface than a bottom-heavy profile, which results from a wider RSD with larger Dg. The modeled REF and change in d are also more strongly influenced by cloud base Dg and σ rather than the concentration of raindrops. The model results are accurate as long as the variations in the relative humidity conditions are accounted for. Relative humidity alone, however, is a poor indicator of sub-cloud rain evaporation. Overall, our analysis indicates the intricate dependence of sub-cloud rain evaporation on both thermodynamic and microphysical processes in the trade wind region.
Revision of an open-split-based dual-inlet system for elemental and isotope ratio mass spectrometers with a focus on clumped-isotope measurements
Authors: Räss Stephan , Nyfeler Peter , Wheeler Paul , Price Will , Leuenberger Markus Christian
Published: October 2023

Abstract. In this work, we present a revision of an open-split-based dual-inlet system for elemental and isotope ratio mass spectrometers (IRMSs), which was developed by the division of Climate and Environmental Physics of the University of Bern 2 decades ago. Besides discussing the corresponding improvements we show that with this inlet system (NIS-II, New Inlet System II) external precisions can be achieved that are high enough to perform measurements of multiply substituted isotopologues (clumped isotopes) on pure gases. For clumped-isotope ratios 35/32 and 36/32 of oxygen, we achieved standard deviations of 3.4×10-9 and 4.9×10-9, respectively, that we calculated from 60 interval means (20 s integration) of pure-oxygen gas measurements. Moreover, we report various performance tests and show that delta values of various air components can be measured with precisions of the order of tens of per meg and higher with the NIS-II. In addition, we demonstrate that our new open-split-based dual-inlet system allows us to measure some of these delta values with significantly higher precisions than an NIS-I (precursor of the NIS-II) and conventional changeover-valve-based dual-inlet systems (tests performed with two dual-inlet systems built by Elementar and Thermo Finnigan). Especially, our measurements point out that our inlet system provides reliable results at short idle times (20 s) and that the corresponding data do not need to be corrected for non-linearity. However, the sample consumption of our open-split-based dual-inlet system is several orders of magnitude higher than that of changeover-valve-based ones (0.33 sccm versus 0.005 sccm; standard cubic centimetres per minute). Due to the successful preliminary tests regarding measurements of clumped-isotope ratios, we will continue our work in this area to perform clumped-isotope studies according to common practices.
Characterisation of dust aerosols from ALADIN and CALIOP measurements
Authors: Song Rui , Povey Adam , Grainger Roy G.
Published: October 2023

Abstract. Atmospheric aerosols have a pronounced effect on climate dynamics at both regional and global scales, but the magnitude of these effects is subject to considerable uncertainties. A major contributor to these uncertainties is the incomplete understanding of aerosol's vertical structure, largely due to observational limitations. Spaceborne lidars can directly observe the vertical distribution of aerosols globally, and are increasingly used in atmospheric aerosol remote sensing. As the first spaceborne High Spectral Resolution Lidar (HSRL), the ALADIN instrument onboard the Aeolus satellite was operational from 2018 to 2023. With its sophisticated design, ALADIN can retrieve aerosol backscatter and extinction coefficients separately without an assumption of the lidar ratio. This study is dedicated to assessing the performance of ALADIN's aerosol retrieval capabilities by comparing them with CALIOP measurements. A statistical analysis of retrievals from both instruments during the June 2020 Saharan dust event indicates good consistency between the observed backscatter and extinction coefficients. A detailed comparison of extinction coefficients for dust layers reveals that ALADIN is more susceptible to signal attenuation than CALIOP. During this extreme dust event, CALIOP-derived aerosol optical depth (AOD) exhibited large discrepancies with MODIS Aqua measurements. Using collocated ALADIN observations to revise the dust lidar ratio to 63.5 sr, AODs retrieved from CALIOP are increased by 46 %, improving the comparison with MODIS data. Further, the combination of measurements from ALADIN and CALIOP can enhance the tracking of aerosols' vertical transport. This study demonstrates the potential for spaceborne HSRL to retrieve aerosol optical properties. It highlights the benefits of spaceborne HSRL in directly obtaining the lidar ratio, significantly reducing uncertainties in extinction retrievals. This work paves the way for forthcoming spaceborne HSRL missions, particularly the ESA ATLID space lidar (set for a 2024 launch) and Aeolus-2.
Significant role of physical transport in the marine carbon monoxide (CO) cycle – Observations in the East Sea (Sea of Japan), the Western North Pacific, and the Bering Sea in summer
Authors: Kwon Young Shin , Rhee Tae Siek , Kim Hyun-Cheol , Kang Hyoun-Woo
Published: October 2023

Abstract. The carbon monoxide (CO) in the marine boundary layer and in the surface waters and water column were measured along the Northwestern Pacific limb from Korean Peninsula to Alaska, U.S.A. in summer 2012. The observation allows us to estimate the CO budgets in the surface mixed layer of the three distinct regimes, the East Sea (ES), the Northwest Pacific (NP), and the Bering Sea (BS). Microbial consumption rates were 33(±22) μmol m-2 day-1, 23(±11) μmol m-2 day-1, and 77(±32) μmol m-2 day-1, and CO production rates were 70(±49) μmol m-2 day-1, 20(±11) μmol m-2 day-1, and 19(±7) μmol m-2 day-1 in ES, NP and BS, respectively, both of which are the dominant components of the CO budget in the ocean. The other two known components, air-sea gas exchange and downward mixing remain negligible (less than 2 μmol m-2 day-1) in all regimes. While the CO budget in the surface mixed layer of NP is in balance, the CO production surpassed the consumption in ES and vice versa in BS. The significant imbalances in the CO budget in ES and BS requires external physical transport such as lateral advection, subduction, or ventilation. Indeed, the first order increase of the CO column burden to the extent that the imbalance in the CO budget increases points to the significant play of the physical transport in the CO cycles. Our observation, for the first time, points to the potential importance of physical transport in the marine CO cycle.
Understanding biases in ICESat-2 data due to subsurface scattering using Airborne Topographic Mapper waveform data
Authors: Smith Benjamin , Studinger Michael , Sutterley Tyler , Fair Zachary , Neumann Thomas
Published: October 2023

Abstract. The process of laser light reflecting from surfaces made of scattering materials that do not strongly absorb at the wavelength of the laser can involve reflections from hundreds or thousands of individual grains, which can introduce delays in the time between light entering and leaving the surface. These time of flight biases depend on the grain size and density of the medium, and so can result in spatially and temporally varying surface height biases estimated from NASA’s ICESat-2 (Ice Cloud, and land Elevation Satellite-2) mission. In this study, we investigate these biases using a model of subsurface scattering, altimetry measurements form NASA’s ATM (Airborne Topographic Mapping system), and grain-size estimates based on optical imagery of the ice sheet. We demonstrate that distortions in the shapes of waveforms measured using ATM are related to the optical grain size of the surface estimated using optical reflectance measurements, and argue that they can be used to estimate an effective grain radius for the surface. Using this effective grain radius as a proxy for the severity of subsurface scattering, we use our model with grain-size estimates from optical imagery to simulate corrections for biases in ICESat-2 data due to subsurface scattering, and demonstrate that on the basis of large-scale averages, the corrections calculated based on the optical imagery match the biases in the data. This work demonstrates that waveform-based altimetry data has the potential to measure the optical properties of granular surfaces, and that corrections based on optical grain-size estimates have the potential to correct for subsurface-scattering biases in ICESat-2 data.
ТҰЛҒАНЫҢ СЫБАЙЛАС ЖЕМҚОРЛЫҚҚА ҚАРСЫ САНАНЫ ЖӘНЕ ҚАЗАҚСТАН РЕСПУБЛИКАСЫНДАҒЫ СЫБАЙЛАС ЖЕМҚОРЛЫҚҚА ҚАРСЫ МӘДЕНИЕТ
Authors: СЕЙТХОЖИН Б. , САРСЕМБАЕВ Б.
Published: October 2023

В настоящей статье рассматриваются вопросы антикоррупционной правовой культуры в обществе, являющиеся фундаментом формирования правосознания личности, направленные на первостепенное создание атмосферы нетерпимости по отношению к коррупционерам, в современных социально-экономических условиях развития нашего государства. Одной из актуальных и социально значимых задач, безусловно, является поиск путей снижения роста коррупционных преступлений и повышенная эффективность их предупреждения.

Осы мақалада жеке тұлғаның құқықтық санасын қалыптастырудың іргетасы болып табылатын, мемлекетіміздің қазіргі әлеуметтік-экономикалық даму жағдайында сыбайлас жемқорлыққа төзбеушілік атмосферасын бастапқы құруға бағытталған қоғамдағы сыбайлас жемқорлыққа қарсы құқықтық мәдениет мәселелері қарастырылады. Өзекті және әлеуметтік маңызы бар міндеттердің бірі, сөз жоқ, Сыбайлас жемқорлық қылмыстардың өсуін төмендету жолдарын іздеу және олардың алдын алудың жоғары тиімділігі болып табылады.

This article examines the issues of anti-corruption legal culture in society, which are the foundation of the formation of legal consciousness of the individual, aimed at the primary creation of an atmosphere of intolerance towards corrupt officials in the modern socio-economic conditions of the development of our state. One of the urgent and socially significant tasks, of course, is to find ways to reduce the growth of corruption crimes and increase the effectiveness of their prevention.
The Assessment of Groundwater Availability in Sedimentary Environments Using the Electrical Resistivity Method: A Case of Ekpoma and Its Environs, Southern Nigeria
Authors: Idiahi Endurance , Adiat Kola Abdul Nafiu , Ozegin Kesyton Oyamenda , Salufu Samuel Obomheile , Adebayo Stephen , Akinlalu Ayokunle Adewale
Published: October 2023

Groundwater resources are an ephemeral aspect of the ecosystem, especially in the university town of Ekpoma, where the issue of severe water shortages brought on by failed or unproductive boreholes has lingered over time. This study makes an effort to thoroughly define the groundwater-bearing zones and estimate their thicknesses and depths in order to identify the cause(s) of groundwater scarcity in Ekpoma and its peri-urban area. In order to accomplish the objectives of the work, fifteen (15) Vertical Electrical Soundings (VES) were conducted across the study location, leveraging Schlumberger electrode array, with current electrode spacing varying from 5.00 to 550.00 m. The results show there were five distinct geoelectrical strata identified: top soil, clayey sandstone, sand, consolidated sandstone, and unconsolidated sandstone. The unconsolidated sandstone layer constituted the aquifer units in the area, whose depth ranges between 103.00 m and 258.00 m. Besides, this study showed that there is strong indication/evidence of saturation of the aquifer identified in the Imo Shale Formation surrounding Irrua with highly porous and permeable materials atop it, justifying the region's highly productive wells and boreholes. The aquifers delineated in and around the Ekpoma community, on the other hand, have relatively high resistive values (3404.20–5303.00 ?m), indicating less saturation, and are equally overlain by less porous and permeable materials, establishing why Ekpoma (located within the Bende-Ameki and Ogwashi Asaba Formations) has a perennial groundwater shortage.  The shallow aquifer units in the area of study were discovered to be rather thin, with the majority having a thickness of less than 30 m, making them less sustainable for long-term groundwater abstraction and resulting in failed boreholes in most portions of Ekpoma town. The study indicates that the groundwater prospects of Ekpoma and its environs are poor, and deep boreholes reaching a minimum depth of 250.00 m should be drilled since it is sustainable due to its significant thickness to serve the Ekpoma community and its environs. The present investigation findings can aid in improving knowledge of underlying geological conditions, evaluating the feasibility of the researched area for predicted urban and economic development, and sustaining water supply for connected activities.
Harmonization of ASEAN Policy in Responding to the Phenomenon of Migration and Prevention of Transnational Crime
Authors: Bakker Felix Ferdin , Putri Respati Triana , Deputra Ale Alfero
Published: October 2023

The existence of migration and technological developments at present make the boundaries between countries even more invisible. ASEAN's position in Southeast Asia is becoming increasingly problematic. Currently, the development of crimes in the Southeast Asian region which is increasingly widespread makes it necessary to strengthen cooperation between countries through the ASEAN organization. Until now, the ASEAN Ministerial Meeting on Transnational Crimes (AMMTC) has not been able to equalize perceptions between ASEAN countries in formulating policies. This research itself is based on these problems with research based on juridical normative research methods. Normative legal research is also called doctrinal legal research, library research, or documentary studies. It is hoped that with an organization that brings together elements of border and security in ASEAN, policies can be more focused. Besides, Indonesia's position as a large country in ASEAN is also required to play a more active role in solving this problem.
The Role Of Immigration Civil Servant Investigator In The Legal History Of Indonesia
Authors: Prabowo Yogi
Published: October 2023

To deal with the excesses of the flow of cross-border human movement, immigration is present as an apparatus in regulating the traffic of people in and out of the territory of Indonesia, monitoring the presence and activities of foreigners while in Indonesia, as well as carrying out law enforcement activities in a sustainable and intensive manner. The legal history of Indonesia records that at first the immigration crime was a general crime which later turned into a special crime. With this paradigm change, of course, the authority of the Immigration Civil Servant Investigator will change in carrying out law enforcement. The research used in the preparation of this journal is normative legal research. Normative legal research, which can also be called doctrinal legal research, usually only uses secondary data sources, namely laws and regulations, court decisions, legal theory, and the opinions of leading scholars. Analysis of the data used is normative legal analysis because the object of this research is legislation that has permanent and binding legal force. There are 3 (three) laws and regulations that mention the role of Immigration Civil Servant Investigator in conducting criminal investigations. Immigration, namely through Emergency Law Number 8 of 1955 regarding Immigration Crimes, Law Number 9 of 1992 regarding Immigration and Law Number 6 of 2011 regarding Immigration. In each period of enactment of this regulation, the role of Immigration Civil Servant Investigator in carrying out law enforcement is increasing. It is hoped that with the increase in duties and authorities, Immigration Civil Servant Investigator can become independent Investigator in investigating immigration crimes.
Overview Of Home Ownership Law For Foreigners In The Context Of A Second Home In Indonesia
Authors: Abdullah N Apriansyah , Nirwana Ridwan , Kamilah Anita
Published: October 2023

The presence of Act Number 11 of 2020 concerning Job Creation provides several changes in several sectors including in the field of immigration which provides opportunities for foreigners to live in the framework of a second home with a residence permit period of 5 to 10 years and can be extended. The purpose of the study is to find out the conditions that must be met by foreigners to get a second home in Indonesia, and the legal basis for owning a second home from foreigners in Indonesia. The approach method used in normative juridical research is to provide legal certainty of land ownership for foreigners in the context of a second home while living in Indonesia. The results of the study are that foreigners who are permitted to obtain residential property in Indonesia are foreign nationals whose existence provides benefits, conducts business, works, or invests in Indonesia, and has a residence permit in accordance with the provisions. As for the dwellings that can be owned by foreigners in the context of a second house, they consist of landed houses which are on the right of use on state land or landed houses which are above the right of use on land with ownership rights or management rights, as well as flats located on above the right of use or right to build on land with management rights and above the right of use or right to build on land with ownership rights.
JURIDICAL STUDY OF STATE ADMINISTRATIVE COURT RULING RELATED TO IMMIGRATION PREVENTION (CASE STUDY NUMBER: 219/G/2017PTUN-JKT SETYA NOVANTO VS. DIRECTOR GENERAL OF IMMIGRATION)
Authors: Prabowo Yogi , Syahuri Taufiqurrohman
Published: October 2023

Prevention means temporary prohibition of person from exiting from the Territory of Indonesia based on particular Immigration reasons or others prescribed by the Law. In the case of immigration prevention against Setya Novanto ordered by the Chairman of the Corruption Eradication Commission (KPK), a lawsuit was filed to the Administrative Court and recorded in Decision Number: 219/G/2017/PTUN-JKT. This research was conducted to answer the following questions: 1) What were the legal considerations of the Judges in issuing Decision Number: 219/G/2017/PTUN-JKT? 2) How was the analysis of the State Administrative Court Decision Number: 219/G/2017/PTUN-JKT? and 3) What were the recommendations for resolving legal issues in administrative disputes within the Directorate General of Immigration? This study used a normative legal research approach, analyzing secondary data in the form of legislation and literature. The research results concluded that the Prevention carried out by the Director General of Immigration was in accordance with the authority specified in legislation and had fulfilled the General Principles of Good Governance. Therefore, the Judges rejected the Plaintiff's lawsuit in its entirety. However, the Defendant's exception was not fully accepted by the Judges, highlighting the need for improvement in resolving administrative disputes within the Directorate General of Immigration to achieve greater quality and professionalism
ASEAN POLICIES IN RESPONDING TO MIGRATION PHENOMENA AND PREVENTING TRANSNATIONAL CRIME
Authors: Samuel Karunia Ferdyan , Rahmat Regita Cahyani , Qolby Ajeep Akbar , Ayu Herdian Adira Khansa
Published: October 2023

Migration and transnational crime are global phenomena that affect this study. The aims of this study are to identify and analyze the policies adopted by ASEAN in dealing with the phenomenon of migration and prevention of transnational crime which is a global problem. This policy has a significant impact on security and stability in the ASEAN region. Through evaluating the effectiveness of their implementation, this study also aims to evaluate the extent to which these policies have been successful in maintaining peace and security in the region. By extending this abstract, this research will investigate the strategy, legal framework, and concrete steps taken by ASEAN to address the challenges of transnational migration and crime. This analysis is expected to provide in-depth insight into the role and impact of ASEAN policies in dealing with this problem, as well as provide recommendations for future policy improvements.
IMPLICATIONS OF AUTOGATE AS THE OPTIMIZATION OF IMMIGRATION TECHNOLOGY IN RELATIONSHIP TO REDUCE THE CRIMINAL ACTION OF HUMAN TRAFFICKING
Authors: Gibran Atsil Syah , Prakita Sekar Arini , Yusuf Muhammad Choirul , Riyadi Sarina
Published: October 2023

Human Trafficking is an extraordinary crime because it is generally involved with sexual offenses and forced labour; which is a clear violation of human rights. Autogate technology has been implemented at Soekarno-Hatta Airport to speed up departure and arrival procedures at the country's entrance; however, it is seen as a potential risk factor for trafficking. While technologies such as biometric scanning and automated processing speed up document checks for immigration with Autogate, fewer opportunities for people to interact directly with security agents increase the risk of trafficking. Some analyzes must consider many variables, such as the security of autogate technology, the expansion of human movement, and the protection of human rights. This essay aims to attenuate how implementing autogate can impact human trafficking. Moreover, with the existence of an autogate, these findings will help policy makers develop more effective steps to prevent human trafficking.
Examining the impact of YouTube vlogging on communication skills in teens with speech and language disorders
Authors: Alelaimat Ali M. , Baibers Haitham Salem , Khasawneh Mohamad Ahmad Saleem
Published: October 2023

The major goal of this research is to examine how vlogging on YouTube affects the communication skills of Jordan teenagers with language and speech disorders. Fifty people, ranging in age from 13 to 18, participated in an eight-week vlogging intervention program designed to improve their communication skills. The results of the pre- and post-tests showed a statistically significant improvement in communicative competence, with the mean difference between the two measures being 10.5. Vlogging has a significant effect as an intervention because of its remarkable ability to actively engage participants in the creation of relevant content, the facilitation of authentic real-life communication experiences, the encouragement of creative and self-expressive expression, and the provision of individualized therapeutic approaches. Adolescents with speech and language disabilities have unique obstacles in communicating, and this study gives insight on the possible use of novel tools, such as vlogging, to address these issues.
Rekreasyonel Egzersizlere Katılan Çocukların Egzersiz Motivasyonu İle Ebeveynlerin Ders Dışı Sportif Etkinliklere Yönelik Tutumları Arasındaki İlişkinin İncelenmesi
Authors: KARAHASAN İlknur , MÜFTÜLER Mine
Published: October 2023

Bu araştırmada rekreasyonel egzersize katılan çocukların egzersiz motivasyonu ile ebeveynlerinin ders dışı sportif etkinliklere yönelik tutumu incelenmiştir. Buna yönelik olarak bu araştırmanın üç amacı bulunmaktadır. Birincisi rekreasyonel egzersizlere katılan çocukların egzersiz motivasyonu ile ebeveynlerin ders dışı sportif etkinliklere yönelik tutumu arasındaki ilişkinin incelenmesidir. Ayrıca rekreasyonel egzersize katılan çocukların egzersiz motivasyonu ve ebeveynlerinin ders dışı sportif etkinliklere yönelik tutumlarının bazı demografik değişkenlere göre farklılıklarının incelemesi de araştırmanın amaçları arasında yer almaktadır. Araştırma grubunu Muğla’nın Menteşe ilçesindeki spor kulüplerinde rekreasyonel egzersizlere katılan ve araştırmaya gönüllü olarak katılmayı kabul eden 245 çocuk sporcu ve onların ebeveynleri oluşturmuştur. Araştırmada veri toplama aracı olarak Rekreasyonel Egzersiz Motivasyon Ölçeği Çocuk Sporcular İçin: Kısa Form (Dinç ve Yavaş Tez, 2019) ve Ders Dışı Sportif Etkinliklere Yönelik Ebeveyn Tutum Ölçeği (Yılmaz ve Güven, 2015) kullanılmıştır. Araştırma anket yoluyla çevrim içi ve yüz yüze toplanmıştır. Araştırmada nicel araştırma yönteminden korelasyonel desen kullanılmıştır. Veri analizinde, normallik testleri uygulanmış olup değişkenler arası ilişkinin incelenmesi için Pearson Korelasyon testi ve demografik bilgilerin karşılaştırılması için bağımsız gruplarda t test ve tek yönlü varyans analizi (ANOVA) uygulanmıştır. Araştırmanın sonucunda rekreasyonel egzersize katılan çocukların egzersiz motivasyon düzeyleri ile ebeveynlerinin ders dışı sportif etkinliklere yönelik tutum düzeyi arasında olumlu yönde ilişki olduğu görülmektedir. Rekreasyonel egzersizlere katılan çocukların bulgularına göre 11-14 yaş arası ve tenis branşıyla ilgilenen çocukların egzersiz motivasyon düzeyi daha yüksek olduğu tespit edilmiştir. Ebeveynlerin ders dışı etkinliklere yönelik tutumu bulgularına göre; kadın velilerin sosyal destek alt boyutunda, memur olan velilerin kişisel gelişim ve sosyal destek alt boyutunda, tek çocuğa sahip olan velilerin akademik algı ve sosyal destek alt boyutunda, spor yapan velilerin kişisel gelişim ve sosyal destek alt boyutunda, aylık aile geliri 10000 TL ve üstü olan velilerin kişisel gelişim ve sosyal destek alt boyutunda diğer değişkenlere göre tutum düzeylerinin daha yüksek olduğu görülmektedir.
LncRNAs 60248.51 and 9826.1 are identified as potential regulators of endometrial receptivity in Tibetan Northwest Cashmere goats
Authors: SUO Langda , WEI Yucheng , WANG Bin , DE Ji , AWANG Cuoji , RENQING Cuomu , CUI Jiuzeng , LIU Xiaorui , BA Gui , ZHANG Lei
Published: October 2023

Endometrial receptivity is a key determinant of embryo implantation, which is the initial step of a successful pregnancy. In this study, high-throughput RNA sequencing was conducted in pre-receptive endometrium (PE) and receptive endometrium (RE) derived from Tibetan Northwest Cashmere goats. There were only a handful of miRNAs and circRNAs differentially expressed between PE and RE tissues, while there were 250 upregulated coding genes and 193 upregulated lncRNAs and 135 downregulated coding genes and 123 downregulated lncRNAs in RE tissues, suggesting the predominant role of coding genes and lncRNAs in the regulation of endometrial receptivity. Moreover, gene ontology and Kyoto Encyclopedia of Genes and Genomes analyses revealed that differentially expressed lncRNAs are significantly enriched in Wnt, Hedgehog, and Hippo signaling pathways. Furthermore, the two most upregulated lncRNAs, MSTRG.60248.51 (1264 bp) and MSTRG.9826.1 (1362 bp), were screened as candidate lncRNAs, and both upregulation of 60248.51 and 9826.1 could activate Wnt and Hippo signaling and promote cell viability, migration, and secretion of endothelin-1, epidermal growth factor, and colony stimulating factor in primary goat endometrial epithelial cells. In summary, lncRNAs 60248.51 and 9826.1, identified as potential regulators of endometrial receptivity in Tibetan Northwest Cashmere goats, improve cell viability, migration, and secretion functions in endometrial epithelial cells, which may be associated with the Wnt and Hippo signaling pathways.
Keywords: Tibetan Northwest cashmere goats; endometrial receptivity; lncRNA 60248.51 and lncRNA 9826.1; primary goat endometrial epithelial cells; the Wnt and Hippo signaling pathways.
Yoğun Bakımda Nadir Bir Ateş Nedeni: Sıtma
Authors: ARICAN ÇELİK Aslı , TAMALI Rıfat , YILMAZ Gülruhsar , KARABACAK Pınar , ÖZCAN Mustafa Soner
Published: October 2023

Sıtma, anofel cinsi sivrisineklerin insanları sokması sonucu bulaşan paraziter bir hastalıktır. Plasmodium falciparum (P Falciparum) en ölümcül tabloya yol açan türüdür, ülkemizde nadir görülür ve genellikle yurtdışı kaynaklıdır. Yoğun bakımda yüksek ateş pek çok klinik durumda karşımıza çıksa da nadir görülen bir durum olan P. Falciparuma bağlı sıtma aklımızda bulunmalıdır Bu olgu sunumunda, yurt dışı seyahat öyküsü bulunan P. Falciparum sıtma tanısı konulan hastanın yoğun bakım takip ve tedavi süreci sunulmuştur.
Nazal Valv ve Tip Stabilitesini Korumak Amacıyla Modifiye Sliding Alar Kartilaj Tekniği Uygulanan Hastaların Retrospektif Analizi
Authors: ÜNVERDİ Ömer Faruk , YÜCEL Sercan
Published: October 2023

GİRİŞ ve AMAÇ: Rinoplastide, internal nazal valv ve eksternal nazal valv stabilitelerinin sağlanması hem görsel hem de fonksiyonel sonuçları doğrudan etkilemektedir. Scroll ligaman kompleksinin bütünlüğü korunarak hazırlanan scroll ligaman kompleksi destekli alar kartilaj flebi internal ve eksternal valv stabilitesinin korunmasında önemli bir görev üstlenmektedir.

YÖNTEM ve GEREÇLER: Nazal şekil bozukluğu nedeniyle opere edilen 25 primer rinoplasti hastası çalışmaya dahil edildi. Nazal flep, scroll ligaman kompleksinin horizontal ve vertikal lifleri tamamen korunarak kaldırıldı. Tip plasti aşamasında alt lateral kartilaj, caudalde 5 mm lik segment korunacak şekilde caudal ve sefalik iki parçaya ayırıldı. Sefalik parça scroll ligaman kompleksi ile bütünlüğü bozulmadan flep olarak caudal parçanın altında hazırlanan cepe yerleştirildi. BULGULAR: Çalışmaya katılan hastaların 19’ u Kadın 6’sı Erkek idi. Hastaların yaş ortalaması 29,6 yıl idi. Takip süresi 14,5 ay idi. Hastaların tümü nefes alıp vermede belirgin iyileşme olduğunubildirdi. Görünümün 24 hastayı memnun ettiği 1 hastayı ise memnun etmediği sözel olarak öğrenildi. Kıkırdakların dışarıdan görünürlüğünde artma veya palpe edilmesi gibi bir komplikasyon gözlenmedi. Hastaların ameliyat sonrası muayenelerinde, internal veya eksternal nazal valv yetmezliği bulguları gözlenmedi.

TARTIŞMA ve SONUÇ: Scroll ligaman kompleksi vertikal ve longitudal liflerden oluşmaktadır. Kompleksin fonksiyonunu yerine getirebilmesi amacıyla bütünlüğünün korunması veya bütünlüğü bozulmuş olgularda tekrar onarılması gerekmektedir. Skroll ligament destekli alar kartilaj flebi, internal ve eksternal nazal valv stabilitesini sağlayan ve scroll ligaman kompleksini bir bütün olarak koruyan bir tekniktir.
Periarticular Injection of Ranawat Suspension in Combination with Tranexamic Acid Reduces Bleeding and Postoperative Pain in Total Knee Arthroplasty
Authors: MORALAR Ülker , PAMUK Çağdaş
Published: October 2023

Objective: The benefits of periarticular injections of local anesthetic agents or tranexamic acid have been previously evaluated in terms of their effects on postoperative pain in a number of orthopedic studies. However, data is lacking on the efficacy of local anesthetic and tranexamic acid combinations that may be used for this purpose. We aimed to investigate the effects of periarticular injection of both tranexamic acid and Ranawat suspension on postoperative pain and bleeding in patients undergoing total knee arthroplasty.

Methods: A total of 124 patients who underwent total knee arthroplasty were consecutively enrolled in this study. Patients were divided into two groups: those receiving the periarticular injection of a cocktail containing the combination of Ranawat suspension and Tranexamic acid and those receiving no injections. Postoperative pain, postoperative tramadol requirement and blood loss were compared between groups.

Results: Hemoglobin and hematocrit levels were significantly higher at third day postoperatively in recipients of periarticular Ranawat suspension and tranexamic acid combination (p=0.044 and p=0.047, respectively). In addition, the amount of drainage blood loss (p
DETERMINATION OF THE EFFECT OF RUTIN ON EPITHHELIAL AND MESENCHIMAL TRANSITION IN PROSTATE CANCER CELLS
Authors: BAL Esra , DEVECİ ÖZKAN Asuman , BETTS Zeynep
Published: October 2023

Objective: The difficulties experienced in the treatment of prostate cancer and the excess of side effects due to chemotherapy have brought the search for alternative treatment strategies. In recent studies, it is known that Rutin (RUT) has an anti-cancer effect on cancer cells. Our study aimed to determine the effects of RUT on epithelial-mesenchymal transition (EMT) in prostate cancer cells, for the first time.

Methods: The anticancer activity of RUT in prostate cancer cells (PC-3) was determined by WST-1, Annexin V ELISA, DAPI and Acridine Orange staining, and the anti-cancer and anti-metastatic properties of RUT were evaluated with the Scratch Assay test. The mRNA expression level of Bax, Bcl-2, Snail, Twist, Vimentin and E-cadherin genes was determined by RT-PCR.

Results: PC-3 cells were treated with RUT (500, 750, 1000, 1500 µM) for 24 and 48 hours. The viability rates decreased with increasing RUT concentration depending on dose and time (p
ARTIFICIAL INTELLIGENCE BASED RATING OF CARPAL TUNNEL SYNDROME EFFICACY IN CLINICAL DIAGNOSIS
Authors: SARICA  DAROL Elif , ECE Yıldız , UZUN Süleyman , ALEMDAR Murat
Published: October 2023

Objective: The most common entrapment neuropathy seen by the clinician is Carpal tunnel syndrome (CTS). CTS is graded as mild, moderate, and severe according to the results obtained on electroneuromyography (ENMG) by clinicians. We aimed to show the effectiveness of the use of artificial intelligence in clinical diagnosis in the grading of CTS.

Methods: In our study, the data of 315 people with a pre-diagnosis of CTS were used and classified into four classes based on AI as CTS grade. Machine Learning (ML) algorithms Ensemble, Support Vector Machine (SVM), K-Nearest Neighbor (KNN), and Decision Tree (Tree) algorithms were used in classification processes. 10% Hold-out validation was used and the learning rate was determined as 0.1. As a result of the classification, accuracy, precision, sensitivity, specificity, and F1-score performance values were obtained.

Results: SVM made the best estimation and KNN made the worst estimation in the 0 class. The best estimate in class 1 belongs to the Support Vector Machine. Ensemble and Tree made the best guesses in the 2nd and 3rd grades. In our study, the best algorithm with an overall success rate is SVM with 93.55%.

Conclusions: The results showed that ML algorithm models consistently provided better predictive results and would assist physicians in determining the medical treatment modality of CTS. Artificial intelligence (AI) techniques are reliable methods that assist clinicians to deliver quality healthcare.
Folded-Stent: The Third Generation Trick to Improve The Microvascular Stenting Technique
Authors: PAMUK Çağdaş
Published: October 2023

Objective: Although microsurgical vessel anastomoses have become a routine procedure today, they are still among the difficult techniques to apply. The most important step in the success of the technique is the clear presentation of the vessel lumen. In this study, we aimed to describe a new technique that will provide an easier anastomosis by keeping the lumen open during microvascular anastomoses.

Methods: Four groups were formed using the chicken wing radial artery, which is an inanimate animal model. One of these was the control group who underwent standard microvascular repair. The second and third groups that followed were those in which two previously defined intravascular stenting techniques were applied. The fourth group was the Folded stent group that we just defined.

Results: Anastomosis time was found to be significantly longer when compared to other groups in our newly defined technique. This time was an average of 3 minutes. No significant difference was observed in terms of the number of sutures used in anastomoses. No posterior wall suture complication was observed in any specimen.

Conclusions: “Folded-Stent” technique provides a great advantage over other stenting techniques in terms of keeping the lumen open during the anastomosis and preventing the adhesion of the vessel walls. It is an advantageous technique that can be used in clinical practice, especially during venous repairs, to prevent posterior wall suturing of small caliber vessels.
Evaluation of colonoscopy and pathology results of patients who underwent colonoscopy due to fecal occult blood test positivity: A single center experience
Authors: SUBAŞI Özkan , TURGUT Hamdi Taner , GUNES Abdullah , DİNDAR Gokhan
Published: October 2023

Objective: The most important part of improving colorectal cancer prognosis is to detect and treat in the early stage. The most effective way to do this is screening programs. Fecal occult blood test is one of the most frequently used methods in the screening program. In this study, we aimed to evaluate the colonoscopy and histopathological findings of patients who underwent colonoscopy due to positive fecal occult blood test.

Methods: Patients who had a positive fecal occult blood test between January 2016 and December 2018 and underwent colonoscopy to investigate the etiology were included in the study. Demographic characteristics, colonoscopy findings and histopathological results of the patients were reviewed retrospectively from hospital records.

Results: A total of 325 patients were included in the study. Of the patients, 146 (44.9%) were male, 179 (55.1%) were female, and their mean age was 58.4±9.3 years. Colonoscopic findings of 140 patients (43.1%) were normal. Polyps in 89 (27.4%) patients, perianal disease in 46 (15.1%), diverticulum in 20 (6.2%), inflammatory bowel disease in 8 (2.4%), solitary rectal ulcers in 4 (1.2%) patients and colorectal cancer in 18 (5.5%) of them was detected.

Conclusion: Fecal occult blood test is a cost-effective and easy-to-apply method used in colorectal cancer screening programs together with colonoscopy, helping to detect both cancer and precancerous lesions and increase the survival rate.
Antineutrophil cytoplasmic antibody serotypes may affect the clinical presentation of patients with granulomatosis with polyangiitis: a single-center, retrospective cross-sectional study
Authors: YAZICI Ayten , SADİOĞLU ÇAĞDAŞ Öznur , ARISAL Ali Osman , ÖZDEMİR IŞIK Özlem , GÖKÇEN Neslihan , ÇEFLE Ayşe
Published: October 2023

Objective: Granulomatosis with polyangiitis (GPA) is one of the systemic vasculitis included in antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV). Clinical characteristics, ANCA serotypes, and their frequencies vary depending on the type of vasculitis. In this study, we aimed to investigate the link between ANCA serotypes and clinical variables documented at the time of admission.

Methods: This study was a retrospective cross-sectional study including 40 patients with GPA. The demographic, clinical, laboratory, and radiological findings were extracted from medical records. Logistic Regression Analysis was performed to estimate the relationship between ANCA serotypes and other variables.

Results: The mean age was 53.95±12.94 years, and there was a delay of 15.85±23.03 months in diagnosis. While constitutional symptoms were observed in 42% of patients, symptoms related to ear-nose-throat in 70%, lung in 87.5%, kidney in 62.5%, neurological findings in 30%, eye in 25%, skin in 25% and musculoskeletal system findings in 90% were noted. Male gender was seen more frequently in cANCA (60.7%) positive patients; however, pANCA-positive patients were mainly female (83.3%) (p=0.050). Delay in diagnosis was longer (p=0.001) and subglottic stenosis was more common (p