bluuebunny/crossref_metadata_2025 huggingface dataset:
Constrained-Spherical Deconvolution Tractography in the Evaluation of the Corticospinal Tract in Glioma Surgery
Authors: Sheng Zhiyuan , Yu Jinliang , Chen Zhongcan , Sun Yong , Bu Xingyao , Wang Meiyun , Sarica Can , Hernesniemi Juha , Nelson Bradley J. , Zemmar Ajmal , Avecillas-Chasin Josue M.
Published: July 2021

Introduction: Tractography has demonstrated utility for surgical resection in the setting of primary brain tumors involving eloquent white matter (WM) pathways.

Methods: Twelve patients with glioma in or near eloquent motor areas were analyzed. The motor status was recorded before and after surgery. Two different tractography approaches were used to generate the motor corticospinal tract (CST): Constrained spherical deconvolution probabilistic tractography (CSD-Prob) and single tensor deterministic tractography (Tens-DET). To define the degree of disruption of the CST after surgical resection of the tumor, we calculated the percentage of the CST affected by surgical resection, which was then correlated with the postoperative motor status. Moreover, the fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) of the CST generated by the CSD-Prob and the Tens-DET was measured and compared between the ipsilesional and contralesional side.

Results: The CST was identified in all patients and its trajectory was displaced by the tumor. Only the CSD-Prob approach showed the CST with the characteristic fan-like projections from the precentral gyrus to the brainstem. Disruption of the CST was identified in 6/6 with postoperative motor deficit by CSD-Prob approach and in 5/6 in the Tens-DET. The degree of disruption was significantly associated with the motor deficit with the CSD-Prob approach (rho = −0.88, p = 0.021). However, with the Tens-DET approach the CST disruption did not show significant association with the motor function (rho = −0.27, p = 0.6). There was a significant decrease in FA (p = 0.006) and a significant increase in MD (p = 0.0004) and RD (p = 0.005) on the ipsilesional CST compared with the contralesional CST only with the CSD-Prob approach.

Conclusion: CSD-Prob accurately represented the known anatomy of the CST and provided a meaningful estimate of microstructural changes of the CST affected by the tumor and its macrostructural damage after surgery. Newer surgical planning stations should include advanced models and algorithms of tractography in order to obtain more meaningful reconstructions of the WM pathways during glioma surgery.
Impact of Laparoscopic Partial Nephrectomy and Open Partial Nephrectomy on Outcomes of Clear Cell Renal Cell Carcinoma
Authors: Yu Feng , Xu Qian , Liu Xian-Gen
Published: July 2021

Objective: To analyze the impact of laparoscopic partial nephrectomy (LPN) and open partial nephrectomy (OPN) on outcomes of complex clear cell renal cell carcinoma (ccRCC).

Methods: A total of 132 high-complex ccRCC patients with a Radius Exophytic Nearness Anterior Location (R.E.N.A.L) score ≥7 enrolled in our hospital between January 2018 and June 2020 were matched and assigned to an LPN group (given LPN treatment) and an OPN group (given OPN treatment), with 66 cases in each group. Two weeks and 3 months after the operation, the renal indexes, inflammatory factors, basic perioperative conditions, and incidence of complications were compared.

Results: Two weeks after the operation, the levels of SCr and CysC were elevated, with higher levels observed in the LPN group (all P < 0.05), and the eGFR levels were reduced, with a lower result in the LPN group. Three months after the operation, the two groups observed decreased levels of SCr and CysC, and an increased level of eGFR; moreover, the decreased SCr and CysC levels were still higher, and the increased eGFR was lower than those before the operation (P < 0.05). The levels of CRP and TNF-α in the two groups increased after the operation, with a lower outcome in the LPN group (P < 0.05). Moreover, the LPN group had less intraoperative blood loss and shorter postoperative length of hospital stay but longer blocking time compared to the OPN group (P < 0.05). Patients in the LPN group were recorded with a lower complication incidence compared with the OPN group (3.03 vs. 15.15%, P < 0.05).

Conclusion: Both LPN and OPN enjoy significant efficacy in the treatment of complex ccRCC and effectively protect renal function. Moreover, LPN is a more acceptable option for complex ccRCC due to its numerous benefits in postoperative stress response, complications, recovery. which is worthy of promotion with safety and feasibility.
Analytical and Early Detection System of Infectious Diseases and Animal Health Status in Kuwait
Authors: Al-Hemoud Ali , AlSaraf Manar , Malak Mariam , Al-Shatti Musab , Al-Jarba Meshael , Othman Ahmad , Al-Shammari Hanadi , Al-Shatti Alya
Published: July 2021

This study aimed at the development of an analytic web-based system for the assessment of animal health in Kuwait. The data sources were based on the World Organization for Animal Health (OIE) and the World Animal Health Information System (WAHIS) repository with data gathered for the period (2005–2020). An on-line web-based system using TABLEAU Creator was developed for monitoring and surveillance of animal disease outbreaks. Five animal diseases were identified in Kuwait; namely, HPAI, FMD, glanders, LSD and MERS-CoV. The highest numbers of outbreaks were recorded for HPAI, followed by FMD. Examples of spatio-temporal visualizations of the web based mappings are presented and include disease cases, number of outbreaks and farm locations, among other features. The web-based system can serve as a monitoring tool to easily display the status of animal health in Kuwait. It can also serve to quickly identify and track disease outbreaks and monitor the spread patterns of new or emerging animal diseases between neighboring countries.
A Novel Estimation of Unobserved Pig Growth Traits for the Purposes of Precision Feeding Methods
Authors: Misiura Maciej M. , Filipe Joao A. N. , Kyriazakis Ilias
Published: July 2021

Recent technological advances make it possible to deliver feeding strategies that can be tailored to the needs of individual pigs in order to optimise the allocation of nutrient resources and contribute toward reducing excess nutrient excretion. However, these efforts are currently hampered by the challenges associated with: (1) estimation of unobserved traits from the available data on bodyweight and feed consumption; and (2) characterisation of the distributions and correlations of these unobserved traits to generate accurate estimates of individual level variation among pigs. Here, alternative quantitative approaches to these challenges, based on the principles of inverse modelling and separately inferring individual level distributions within a Bayesian context were developed and incorporated in a proposed precision feeding modelling framework. The objectives were to: (i) determine the average and distribution of individual traits characterising growth potential and body composition in an empirical population of growing-finishing barrows and gilts; (ii) simulate the growth and excretion of nitrogen and phosphorus of the average pig offered either a commercial two-phase feeding plan, or a precision feeding plan with daily adjustments; and (iii) simulate the growth and excretion of nitrogen and phosphorus across the pig population under two scenarios: a two-phase feeding plan formulated to meet the nutrient requirements of the average pig or a precision feeding plan with daily adjustments for each and every animal in the population. The distributions of mature bodyweight and ratio of lipid to protein weights at maturity had median (IQR) values of 203 (47.8) kg and 2.23 (0.814) kg/kg, respectively; these estimates were obtained without any prior assumptions concerning correlations between the traits. Overall, it was found that a proposed precision feeding strategy could result in considerable reductions in excretion of nitrogen and phosphorus (average pig: 8.07 and 9.17% reduction, respectively; heterogenous pig population: 22.5 and 22.9% reduction, respectively) during the growing-finishing period from 35 to 120 kg bodyweight. This precision feeding modelling framework is anticipated to be a starting point toward more accurate estimation of individual level nutrient requirements, with the general aim of improving the economic and environmental sustainability of future pig production systems.
High Co-infection Status of Novel Porcine Parvovirus 7 With Porcine Circovirus 3 in Sows That Experienced Reproductive Failure
Authors: Mai Jinhui , Wang Dongliang , Zou Yawen , Zhang Sujiao , Meng Chenguang , Wang Aibing , Wang Naidong
Published: July 2021

Porcine parvoviruses (PPVs) and porcine circoviruses (PCVs) infect pigs worldwide, with PPV1–7 and PCV2 infections common in pigs. Although PPV7 was only identified in 2016, co-infection of PPV7 and PCV2 is already common, and PPV7 may stimulate PCV2 replication. PCV3, a novel type of circovirus, is prevalent in pig populations worldwide and considered to cause reproductive disorders and dermatitis nephrotic syndrome. In recent studies, pigs were commonly infected with both PCV3 and PPV7. Our objective was to investigate the co-infections between PPV7 and PCV3 in samples from swine on farms in Hunan, China, and assess the potential impacts of PPV7 on PCV3 viremia. A total of 209 samples, known to be positive (105) or negative (104) for PCV3, were randomly selected from serum samples that were collected from commercial swine herds in seven regions from 2016 to 2018 in our previous studies; these samples were subjected to real-time PCR to detect PPV7. Of these samples, 23% (48/209) were positive for PPV7. Furthermore, the PPV7 positive rate was significantly higher in PCV3 positive serum (31.4%, 33/105) than in PCV3 negative serum (14.4%, 15/104). Another 62 PCV3 positive sow serum samples and 20 PCV3 positive aborted fetuses were selected from 2015 to 2016 in our other previous study. These samples were designated as being from farms with or without long-standing histories of reproductive failure (RF or non-RF), respectively, and they were also subjected to real-time PCR to detect PPV7 and to determine whether PPV7 affected PCV3 viremia. Among the 62 serum samples (39 PCV3 positive RF-serum and 23 PCV3 positive non-RF-serum), 45.1% (28/62) were positive for PPV7 and PCV3, and the PPV7 positive rate was significantly higher in PCV3 positive RF-serum (51.2%, 20/39) than in PCV3 positive non-RF-serum (34.8%, 8/23). In addition, there was a higher positive rate of PPV7 (55%, 11/20) in PCV3 positive aborted fetus samples. In addition, the copy number of PCV3 in PPV7 positive samples was significantly higher than that in PPV7 negative serum samples. Based on these findings, we concluded that PPV7 may stimulate PCV3 replication.
Damping Performance Analysis of Magnetorheological Damper Based on Multiphysics Coupling
Authors: Hu Guoliang , Wu Lifan , Deng Yingjun , Yu Lifan , Luo Bin
Published: July 2021

Magnetorheological (MR) damper performance is evaluated only by single-field analysis in the design process, which can easily lead to larger design errors. Based on this, a simulation method of MR damper considering multiphysics coupling was proposed. According to a certain automobile shock absorber requirement, an MR damper suitable for automobile suspension was designed. The mechanical model, electromagnetic field model, flow field model, and structural stress field model of the MR damper were deduced and established. To investigate the damping performance of the MR damper more accurately, the multiphysics coupling simulation model was established by COMSOL software, and coupling analysis of the electromagnetic field, flow field, and structural stress field was also carried out. The static magnetic field characteristics, dynamic flow field characteristics, stress distribution, and dynamic performance of the proposed MR damper under the action of multiphysics coupling were obtained. The simulation results show that the damping force is 1134.6 N, and the damping adjustable coefficient is 9.1 at an applied current of 1.4 A. A test system was established to analyze the dynamic performance of the MR damper, and the simulation results were compared with the experimental results. The results show that the simulated and experimental results have the same change rule. Moreover, the damping force increases with the applied current, and different external excitations have little effect on the damping force. The damper can output appropriate damping force and has a wide adjustable damping range. The experimental results illustrate that the damping force is 1200.0 N, and the damping adjustable coefficient is 10.1 when the current is 1.4 A. The error between simulation and experiment of the damping force and damping adjustable coefficient is only 5.5% and 9.9%, respectively.
Straw-Based Biopurification Systems to Remove Ibuprofen, Diclofenac and Triclosan from Wastewaters: Dominant Microbial Communities
Authors: Delgado-Moreno Laura , van Dillewijn Pieter , Nogales Rogelio , Romero Esperanza
Published: July 2021

The continued discharge of pharmaceuticals and personal care products (PPCPs) into the environment due to their widespread use and the lack of effective systems for their removal from water is a global problem. In this study, the dissipation of ibuprofen, diclofenac and triclosan added simultaneously in biopurification systems (BPSs) with different compositions and their effect on the microbial community structure was analysed. Three BPSs, constituted by mixtures of soil (S), peat (P), or raw wet olive mill cake (A) or its vermicompost (V) and straw (S) were prepared (SPS, SAS and SVS). Sorption and degradation experiments were carried out. After 84 days of incubation, more than 85% of each PPCP applied had dissipated. Methyl-triclosan was determined to be highest in the SVS biomixture. Biomixtures with lower C/N ratio and higher alpha diversity were the most effective in the removal of PPCPs. Initially, the BPS biomixtures showed a different microbial structure dominated by Proteobacteria, Actinobacteria and Bacteroidetes but after addition of PPCPs, a similar pattern was observed in the relative abundance of the phylum Chloroflexi, the class Sphingobacteriia and the genus Brevundimonas. These biopurification systems can be useful to prevent point source contamination due to the disposal of PPCP-contaminated waters.
Towards a Fair Scope of Protection for Plant Breeders’ Rights in an Era of New Breeding Techniques: Proposals for a Modernization of the Essentially Derived Variety Concept
Authors: Bostyn Sven J. R.
Published: July 2021

Plant breeders’ rights (PBRs) are an important IP right, and as plant breeding has a crucial role to play in sustainability, it is vital that innovations in plant breeding receive the appropriate innovation incentives. The full breeders’ exemption ensures that there is always free access to the plant variety protected by a PBR for developing new varieties. The price to pay for this exemption is that PBR holders cannot prevent third parties from taking advantage of their efforts and investments in developing a new variety. This invites free-riding, at the detriment of the PBR holder. The concept of “essentially derived varieties” (EDV), introduced in 1991, provided a “fix” for this problem. It allows PBR holders to extend, at least to some extent, the scope of protection of their PBR to those varieties which use all or most essential characteristics of the initial protection variety. Decades have passed, but no adequate interpretation of the complex EDV concept has been found. The advent of new breeding techniques (NBTs) has made the discussion about a fair scope of protection of PBRs all the more relevant. This necessitates a modernization of the EDV concept, if the PBR system is to remain relevant and continue to be an innovation-incentivizing mechanism. I argue that a broader scope for the EDV concept is essential and fair. Determining what essential derivation is will remain a difficult task also in the future. This is why I have additionally proposed a collaborative reward model, which will facilitate the functioning of the EDV system and is capable of providing more legal certainty in this area.
Carbohydrate and Amino Acid Dynamics during Grain Growth in Four Temperate Cereals under Well-Watered and Water-Limited Regimes
Authors: Méndez-Espinoza Ana María , Garriga Miguel , Ben Mariem Sinda , Soba David , Aranjuelo Iker , del Pozo Alejandro
Published: July 2021

Grain development in cereals depends on synthesis and remobilisation compounds such as water-soluble carbohydrates (WSCs), amino acids (AAs), minerals and environmental conditions during pre- and post-anthesis. This study analyses the impact of water stress on metabolite (WSCs, AAs and nitrogen) dynamics between the source (leaves and stems) and sink (grain) organs in triticale, bread wheat, durum wheat and barley. Plants were grown in glasshouse conditions under well-watered (WW) and water-limited (WL) regimes (from flag leaf fully expanded until maturity). The results showed that the stem WSC content and the apparent mobilisation of WSC to the grain were much higher in triticale and were associated with its larger grain size and grain number. In the four cereals, grain weight and the number of kernels per spike were positively associated with stem WSC mobilisation. After anthesis, the AA concentration in leaves was much lower than in the grain. In grain, the main AAs in terms of concentration were Asn, Pro and Gln in triticale, bread, and durum wheat, and Asn, Pro and Val in barley. The water-limited regime reduced grain weight per plant in the four cereal species, but it had no clear effects on WSC content and AAs in leaves and grain. In general, triticale was less affected by WL than the other cereals.
Is There a Difference in Microbiological Epidemiology and Effective Empiric Antimicrobial Therapy Comparing Fracture-Related Infection and Periprosthetic Joint Infection? A Retrospective Comparative Study
Authors: Rupp Markus , Baertl Susanne , Walter Nike , Hitzenbichler Florian , Ehrenschwender Martin , Alt Volker
Published: July 2021

This study aims to investigate (1) microbial patterns in fracture-related infections (FRIs) in comparison to microbiological patterns of periprosthetic joint infections (PJIs), (2) the identification of effective empiric antibiotic therapy for FRIs and PJIs and (3) analysis of difficult-to-treat (DTT) pathogens. Patients treated for FRIs or PJIs from 2017 to 2020 were evaluated for pathogens detected during treatment. Antibiotic susceptibility profiles were examined with respect to broadly used antibiotics and antibiotic combinations. Resistance rates to rifampicin or fluoroquinolone were determined. A total of 81 patients with PJI and 86 with FRI were included in the study. For FRIs Staphylococcus aureus was the most common infection-causing pathogen (37.4% vs. 27.9% for PJI). Overall, there was no statistical difference in pathogen distribution (p = 0.254). For FRIs, combinations of gentamicin + vancomycin (93.2%), co-amoxiclav + glycopeptide and meropenem + vancomycin (91.9% each) would have been effective for empiric therapy, similar to PJIs. Difficult to treat pathogens were more frequently detectable in PJIs (11.6% vs. 2.3%). Empiric therapy combinations such as gentamicin + vancomycin, co-amoxiclav + glycopeptide or meropenem + vancomycin, are effective antibiotic strategies for both FRI and PJI patients. More DTT pathogens were detectable in PJIs compared to FRIs.
Prevalence of and Risk Factors for Nonprescription Antibiotic Use among Individuals Presenting to One Hospital in Saudi Arabia after the 2018 Executive Regulations of Health Practice Law: A Cross-Sectional Study
Authors: Al-Hazmi Ali Mohsen , Arafa Ahmed , Sheerah Haytham , Alshehri Khalid Saeed , Alekrish Khalid Alwalid , Abdulla Aleisa Khalid , Jammah Abdullah Ali , Alamri Nawaf Abdullah
Published: July 2021

Antibiotic resistance is a worldwide public health emergency. Nonprescription antibiotic use is a chief cause of antibiotic resistance. The Saudi Government, as a consequence, imposed in 2018 executive regulations to prevent the distribution of antibiotics without a prescription. Herein, we aimed to investigate the prevalence of and risk factors for nonprescription antibiotic use among individuals presenting to one hospital in Saudi Arabia after enacting these regulations. This cross-sectional study was conducted on people, aged ≥18 years, who presented to the primary healthcare clinics of King Khalid University Hospital in Riyadh during the period between 1/1/2019 and 28/2/2019. Participants were asked to fill out a self-administrated questionnaire assessing their nonprescription antibiotic use during the past year in addition to sociodemographic information. Then, logistic regression analyses were performed to calculate the odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for age, sex, education, and nationality of any nonprescription antibiotic use compared with no use within the past year. Out of 463 participants, 62.9% were females, 67.4% were <40 years, and 93.7% were Saudi citizens. Overall, 30.5% of participants reported nonprescription antibiotic use during the past year (19.7% one to two times and 10.8% more than two times). Male and non-Saudi participants were more likely to report any nonprescription antibiotic use, with HRs (95% CIs) of 1.99 (1.30, 3.04) and 3.81 (1.73, 8.35), respectively. The main reasons behind nonprescription antibiotic use were having previous experience with a health condition (69.2%), inaccessibility of healthcare (26.6%), and recommendation from a relative or a friend (16.1%). A major limitation of this study was that it included individuals attending one hospital. Individuals who seek medical consultation could be dissimilar to those who do not see doctors regarding nonprescription antibiotic use.
Methyl Jasmonate Protects the PS II System by Maintaining the Stability of Chloroplast D1 Protein and Accelerating Enzymatic Antioxidants in Heat-Stressed Wheat Plants
Authors: Fatma Mehar , Iqbal Noushina , Sehar Zebus , Alyemeni Mohammed Nasser , Kaushik Prashant , Khan Nafees A. , Ahmad Parvaiz
Published: July 2021

The application of 10 µM methyl jasmonate (MeJA) for the protection of wheat (Triticum aestivum L.) photosystem II (PS II) against heat stress (HS) was studied. Heat stress was induced at 42 °C to established plants, which were then recovered at 25 °C and monitored during their growth for the study duration. Application of MeJA resulted in increased enzymatic antioxidant activity that reduced the content of hydrogen peroxide (H2O2) and thiobarbituric acid reactive substances (TBARS) and enhanced the photosynthetic efficiency. Exogenous MeJA had a beneficial effect on chlorophyll fluorescence under HS and enhanced the pigment system (PS) II system, as observed in a JIP-test, a new tool for chlorophyll fluorescence induction curve. Exogenous MeJA improved the quantum yield of electron transport (ETo/CS) as well as electron transport flux for each reaction center (ET0/RC). However, the specific energy fluxes per reaction center (RC), i.e., TR0/RC (trapping) and DI0/RC (dissipation), were reduced by MeJA. These results indicate that MeJA affects the efficiency of PS II by stabilizing the D1 protein, increasing its abundance, and enhancing the expression of the psbA and psbB genes under HS, which encode proteins of the PS II core RC complex. Thus, MeJA is a potential tool to protect PS II and D1 protein in wheat plants under HS and to accelerate the recovery of the photosynthetic capacity.
Generation of Proton- and Alpha-Induced Nuclear Cross-Section Data via Random Forest Algorithm: Production of Radionuclide 111In
Authors: Hamid Mohamad Amin Bin , Beh Hoe Guan , Oluwatobi Yusuff Afeez , Chew Xiao Yan , Ayub Saba
Published: July 2021

We investigated the generation of proton- and alpha-induced nuclear cross-section data in the production of Indium-111 (111In) for application in nuclear medicine. Here, we are interested in three reaction channels, which are 109Ag (α, 2n), 111Cd (p, n) and 112Cd (p, 2n), in the production of 111In. A random forest algorithm was used to generate nuclear cross-section data by using an experimental nuclear cross-section from the Experimental Nuclear Reaction Data (EXFOR) database as input. Hence, reasonably accurate regression curves of nuclear cross-section data could be produced with the evaluated nuclear data library ENDF/B-VII.0 set as the benchmark.
Effect of Citrate on the Size and the Magnetic Properties of Primary Fe3O4 Nanoparticles and Their Aggregates
Authors: Atrei Andrea , Mahdizadeh Fariba Fahmideh , Baratto Maria Camilla , Scala Andrea
Published: July 2021

The size, size distribution and magnetic properties of magnetite nanoparticles (NPs) prepared by co-precipitation without citrate, in the presence of citrate and citrate adsorbed post-synthesis were studied by X-ray Diffraction (XRD), Dynamic Light Scattering (DLS), Electron Paramagnetic Resonance (EPR) and magnetization measurements. The aim of this investigation was to clarify the effect of citrate ions on the size and magnetic properties of magnetite NPs. The size of the primary NPs, as determined by analysing the width of diffraction peaks using various methods, was ca. 10 nm for bare magnetite NPs and with citrate adsorbed post-synthesis, whereas it was around 5 nm for the NPs co-precipitated in the presence of citrate. DLS measurements show that the three types of NPs form aggregates (100–200 nm in diameter) but the dispersions of the citrate-coated NPs are more stable against sedimentation than those of bare NPs. The sizes and size distributions determined by XRD are in good agreement with those of the magnetic domains obtained by fitting of the magnetization vs. magnetic field intensity curves. Magnetization vs. magnetic field intensity curves show that the three kinds of sample are superparamagnetic.
Identification of Novel Inhibitors of Type-I Mycobacterium Tuberculosis Fatty Acid Synthase Using Docking-Based Virtual Screening and Molecular Dynamics Simulation
Authors: Singh Nidhi , Mao Shi-Qing , Li Wenjin
Published: July 2021

Mycobacterial fatty acid synthase type-I (FAS-I) has an important role in the de novo synthesis of fatty acids, which constitute a major component of the cell wall. The essentiality of FAS-I in the survival and growth of mycobacterium makes it an attractive drug target. However, targeted inhibitors against Mycobacterial FAS-I have not been reported yet. Recently, the structure of FAS-I from Mycobacterium tuberculosis was solved. Therefore, in a quest to find potential inhibitors against FAS-I, molecular docking-based virtual screening and molecular dynamics simulation were done. Subsequently, molecular dynamic simulations based on binding free energy calculations were done to gain insight into the predicted binding mode of putative hits. The detailed analysis resulted in the selection of four putative inhibitors. For compounds BTB14738, RH00608, SPB02705, and CD01000, binding free energy was calculated as −72.27 ± 12.63, −68.06 ± 11.80, −63.57 ± 12.22, and −51.28 ± 13.74 KJ/mol, respectively. These compounds are proposed to be promising pioneer hits.
Making Order in User Experience Research to Support Its Application in Design and Beyond
Authors: Berni Aurora , Borgianni Yuri
Published: July 2021

The term User Experience (UX) was introduced to define the dynamics of the human-product interaction, and it was thought that design would have been a main recipient of UX research. However, it can be claimed that the outcomes of UX studies were not seamlessly transferred into design research and practice. Among the possible reasons, this paper addresses the fragmentary knowledge ascribable to the field of UX. The authors reviewed the literature analyzing the conceptual contributions that interpret UX, proposing definitions and/or a theoretical framework. This allowed the authors to provide an overview of recurring elements of UX, highlighting their relationships and affecting factors. This research aims to clarify the overall understanding of UX, along with its key components (the user, interaction, the system, and context) and dimensions (ergonomic, affective, and the cognitive experiences). The authors built a semantic construction inspired by the structure of a grammatical sentence to highlight the relationship between those components. Therefore, UX is defined by a subject/user who performs an action-interaction towards an object-system. A complement-context better defines the condition(s) where the action-interaction takes place. This work is expected to lay the foundations for the understanding of approaches and methods employed in UX studies, especially in design.
Technosols Development in an Abandoned Mining Area and Environmental Risk Assessment
Authors: Ferronato Chiara , Vianello Gilmo , Feudis Mauro De , Vittori Antisari Livia
Published: July 2021

The study of Technosols development, spatial distribution and physicochemical characteristics is becoming more and more important in the Anthropocene Era. The aim of the present study was to assess soil features and potential heavy metal release risk of soils developed on different mine tailing types after the waste disposal derived from mining activity in Central Italy. Soils were analyzed for their morphological, physical and chemical properties, and a chemical sequential extraction of heavy metals was performed. The investigated soils were classified as Technosols toxic having in some layer within 50 cm of the soil surface inorganic materials with high concentrations of toxic elements. Our findings showed that the bioavailability of potentially toxic element concentrations in the soil changed according to the origin of the mine tailing. However, because of the acidic pH, there is a serious risk of metals leaching which was reduced where the soil organic matter content was higher.
Early-, Late-, and Very Late-Term Prediction of Target Lesion Failure in Coronary Artery Stent Patients: An International Multi-Site Study
Authors: Pachl Elisabeth , Zamanian Alireza , Stieler Myriam , Bahr Calvin , Ahmidi Narges
Published: July 2021

The main intervention for coronary artery disease is stent implantation. We aim to predict post-intervention target lesion failure (TLF) months before its onset, an extremely challenging task in clinics. This post-intervention decision support tool helps physicians to identify at-risk patients much earlier and to inform their follow-up care. We developed a novel machine-learning model with three components: a TLF predictor at discharge via a combination of nine conventional models and a super-learner, a risk score predictor for time-to-TLF, and an update function to manage the size of the at-risk cohort. We collected data in a prospective study from 120 medical centers in over 25 countries. All 1975 patients were enrolled during Phase I (2016–2020) and were followed up for five years post-intervention. During Phase I, 151 patients (7.6%) developed TLF, which we used for training. Additionally, 12 patients developed TLF after Phase I (right-censored). Our algorithm successfully classifies 1635 patients as not at risk (TNR = 90.23%) and predicts TLF for 86 patients (TPR = 52.76%), outperforming its training by identifying 33% of the right-censored patients. We also compare our model against five state of the art models, outperforming them all. Our prediction tool is able to optimize for both achieving higher sensitivity and maintaining a reasonable size for the at-risk cohort over time.
Parametric Analysis of the Edge Capacitance of Uniform Slots and Application to Frequency-Variation Permittivity Sensors
Authors: Muñoz-Enano Jonathan , Martel Jesús , Vélez Paris , Medina Francisco , Su Lijuan , Martín Ferran
Published: July 2021

This paper presents a parametric analysis relative to the effects of the dielectric constant of the substrate, substrate thickness and slot width on the edge capacitance of a slot-based resonator. The interest is to find the conditions (ranges of the previously cited parameters) compatible with the presence of a quasi-magnetic wall in the plane of the slot (or plane of the metallization). If such magnetic wall is present (or roughly present), the electric field in the plane of the slot is tangential (or quasi-tangential) to it and the edge capacitance can be considered to be the parallel combination of the capacitances at both sides of the slot. Moreover, variations in one of such capacitances, e.g., caused by a change in the material on top of the slot, or by a modification of the dielectric constant of the substrate do not affect the opposite capacitance. Under the magnetic wall approximation, the capacitance of certain electrically small slot-based resonators can be easily linked to the dielectric constant of the material present on top of it. The consequence is that such resonators can be used as sensing elements in a permittivity sensor and the dielectric constant of the so-called material under test (MUT) can be determined from the measured resonance frequency and a simple analytical expression. In this paper, the results of this parametric analysis are validated by considering several sensing structures based on dumbbell defect ground structure (DB-DGS) resonators of different dimensions.
Silver Sintering for Silicon Carbide Die Attach: Process Optimization and Structural Modeling
Authors: Calabretta Michele , Sitta Alessandro , Oliveri Salvatore Massimo , Sequenzia Gaetano
Published: July 2021

The increasing demand in automotive markets is leading the semiconductor industries to develop high-performance and highly reliable power devices. Silicon carbide MOSFET chips are replacing silicon-based solutions through their improved electric and thermal capabilities. In order to support the development of these novel semiconductors, packaging technologies are evolving to provide enough reliable products. Silver sintering is one of the most promising technologies for die attach. Due to their superior reliability properties with respect to conventional soft solder compounds, dedicated reliability flow and physical analyses should be designed and employed for sintering process optimization and durability assessment. This paper proposes an experimental methodology to optimize the pressure value applied during the silver sintering manufacturing of a silicon carbide power MOSFET molded package. The evaluation of the best pressure value is based on scanning electron microscopy performed after a liquid-to-liquid thermal shock reliability test. Furthermore, the sintering layer degradation is monitored during durability stress by scanning the acoustic microscopy and electric measurement of a temperature sensitive electric parameter. Moreover, mechanical elastoplastic behavior is characterized by uniaxial tensile test for a bulk sample and finite element analysis is developed to predict the mechanical behavior as a function of void fraction inside sintering layer.
On Aerodynamic Models for Flutter Analysis: A Systematic Overview and Comparative Assessment
Authors: Berci Marco
Published: July 2021

This work reviews different analytical formulations for the time-dependent aerodynamic load of a thin aerofoil and clarifies numerical flutter results available in the literature for the typical section of a flexible wing; inviscid, two-dimensional, incompressible, potential flow is considered in all test cases. The latter are investigated using the exact theory for small airflow perturbations, which involves both circulatory and non-circulatory effects of different nature, complemented by the p-k flutter analysis. Starting from unsteady aerodynamics and ending with steady aerodynamics, quasi-unsteady and quasi-steady aerodynamic models are systematically derived by successive simplifications within a unified approach. The influence of the aerodynamic approximations on the aeroelastic stability boundary is then rigorously assessed from both physical and mathematical perspectives. All aerodynamic models are critically discussed and compared in the light of the numerical results as well, within a comprehensive theoretical framework in practice. In all cases, results accuracy depends on the aero-structural arrangement of the flexible wing; however, simplified unsteady and simplified quasi-unsteady aerodynamic approximations are suggested for robust flutter analysis whenever the wing’s elastic axis lies ahead of the aerofoil’s control point.
Regional Climate Models Validation for Agroclimatology in Romania
Authors: Bartok Blanka , Telcian Adrian-Sorin , Săcărea Christian , Horvath Csaba , Croitoru Adina-Eliza , Stoian Vlad
Published: July 2021

Regional climate projections are widely used in impact studies such as adaptations in agronomy. The big challenge of the climate modeling community is to serve valuable instructions regarding the reliability of these simulations to encourage agronomists to use this kind of information properly. The study validates 15 high-resolution ensembles from the Coordinated Regional Climate Downscaling Experiment-European Domain (EURO-CORDEX) for maximum temperature, minimum temperature, and precipitation to fulfill this task. Three evaluation metrics are calculated (mean absolute error, root mean square error, and correlation) for the means and the 5th and 95th percentiles. The analyses are elaborated for annual and monthly means and the vegetation periods of maize and winter wheat. Only arable lands are considered to exclude the effects of the topography. Furthermore, an ensemble selection is applied based on the evaluation metrics to reduce the data use. The five models with the best performance in the case of winter wheat are CNRM-CM5-CLMcom-CCLM4-8-17_v1, MOHC-HadGEM2-ES-IPSL-WRF381P_v1, MOHC-HadGEM2-ES-KNMI-RACMO22E_v2, MOHC-HadGEM2-ES-CLMcom-CCLM4-8-17_v1, and MPI-M-MPI-ESM-LR-KNMI-RACMO22E_v1. In the case of the vegetation period of maize, the models with the best skills are MPI-M-MPI-ESM-LR-KNMI-RACMO22E_v1, CNRM-CM5-IPSL-WRF381P_v2, MPI-M-MPI-ESM-LR-SMHI-RCA4_v1a, MOHC-HadGEM2-ES-IPSL-WRF381P_v1, and MOHC-HadGEM2-ES-KNMI-RACMO22E_v2. Quantifying the errors in climate simulations against observations and elaborating a selection procedure, we developed a consistent ensemble of high time and space resolution climate projections for agricultural use in Romania.
Adaptation of an Invasive Pest to Novel Environments: Life History Traits of Drosophila suzukii in Coastal and Mainland Areas of Greece during Overwintering
Authors: Papanastasiou Stella A. , Rodovitis Vasilis G. , Verykouki Eleni , Bataka Evmorfia P. , Papadopoulos Nikos T.
Published: July 2021

Drosophila suzukii is a polyphagous pest of small and soft fruit, originating from Asia, which has spread and established in Europe and the USA. Adults exhibit seasonal phenotypes, i.e., summer morphs (SM) and winter morphs (WM) to cope with fluctuating environmental conditions. WM have a darker cuticle and larger wings compared to SM, while WM females experience reproductive dormancy. We studied the life history traits (lifespan, female reproductive status and number of produced offspring) of WM and SM that were exposed to winter field conditions of a coastal and a mainland agricultural area, with mild and cold winter climates, respectively. Mated adults of each phenotype were individually placed in vials bearing nutritional/oviposition substrate, and transferred to the field from November 2019 to May 2020, when the death of the last individual was recorded. Almost all SM females (90%) and no WM female carried mature ovarioles before being transferred to the field. WM exhibited a longer lifespan than SM adjusting for location and sex. Differences in survival between the two phenotypes were more pronounced for adults kept in the mainland area. The majority of SM females produced offspring during overwintering in the mild coastal area, but only a few SM were reproductively active in the cold mainland area. Some WM females produced progeny during overwintering in the mild conditions of the coastal area, but all WM females were in reproductive arrest in the mainland area. Overwintering females in the coastal area had a shorter lifespan and produced more progeny than those kept in the mainland area. High survival rates of WM provide indications of the successful performance of this phenotype in the adverse conditions of the cold climates. Additionally, the continuous reproductive activity of SM females and the onset of progeny production by WM females during overwintering in the coastal area indicate that the insect remains reproductively active throughout the year in areas with mild climatic conditions. Our findings support the successful adaptation of D. suzukii in both areas tested and can be used for the development of area-specific population models, based on the prevailing climatic conditions.
Real-Time Analysis of Oxygen Gradient in Oocyte Respiration Using a High-Density Microelectrode Array
Authors: Tedjo William , Obeidat Yusra , Catandi Giovana , Carnevale Elaine , Chen Thomas
Published: July 2021

Physiological events related to oxygen concentration gradients provide valuable information to determine the state of metabolizing biological cells. The existing oxygen sensing methods (i.e., optical photoluminescence, magnetic resonance, and scanning electrochemical) are well-established and optimized for existing in vitro analyses. However, such methods also present various limitations in resolution, real-time sensing performance, complexity, and costs. An electrochemical imaging system with an integrated microelectrode array (MEA) would offer attractive means of measuring oxygen consumption rate (OCR) based on the cell’s two-dimensional (2D) oxygen concentration gradient. This paper presents an application of an electrochemical sensor platform with a custom-designed complementary-metal-oxide-semiconductor (CMOS)-based microchip and its Pt-coated surface MEA. The high-density MEA provides 16,064 individual electrochemical pixels that cover a 3.6 mm × 3.6 mm area. Utilizing the three-electrode configuration, the system is capable of imaging low oxygen concentration (18.3 µM, 0.58 mg/L, or 13.8 mmHg) at 27.5 µm spatial resolution and up to 4 Hz temporal resolution. In vitro oxygen imaging experiments were performed to analyze bovine cumulus-oocytes-complexes cells OCR and oxygen flux density. The integration of a microfluidic system allows proper bio-sample handling and delivery to the MEA surface for imaging. Finally, the imaging results are processed and presented as 2D heatmaps, representing the dissolved oxygen concentration in the immediate proximity of the MEA. This paper provides the results of real-time 2D imaging of OCR of live cells/tissues to gain spatial and temporal dynamics of target cell metabolism.
Change in Blood Flow Velocity Pulse Waveform during Plateau Waves of Intracranial Pressure
Authors: Sawicki Karol , Placek Michał M. , Łysoń Tomasz , Mariak Zenon , Chrzanowski Robert , Czosnyka Marek
Published: July 2021

A reliable method for non-invasive detection of dangerous intracranial pressure (ICP) elevations is still unavailable. In this preliminary study, we investigate quantitatively our observation that superimposing waveforms of transcranial Doppler blood flow velocity (FV) and arterial blood pressure (ABP) may help in non-invasive identification of ICP plateau waves. Recordings of FV, ABP and ICP in 160 patients with severe head injury (treated in the Neurocritical Care Unit at Addenbrookes Hospital, Cambridge, UK) were reviewed retrospectively. From that cohort, we identified 18 plateau waves registered in eight patients. A “measure of dissimilarity” (Dissimilarity/Difference Index, DI) between ABP and FV waveforms was calculated in three following steps: 1. fragmentation of ABP and FV signal according to cardiac cycle; 2. obtaining the normalised representative ABP and FV cycles; and finally; 3. assessing their difference, represented by the area between both curves. DI appeared to discriminate ICP plateau waves from baseline episodes slightly better than conventional pulsatility index did: area under ROC curve 0.92 vs. 0.90, sensitivity 0.81 vs. 0.69, accuracy 0.88 vs. 0.84, respectively. The concept of DI, if further tested and improved, might be used for non-invasive detection of ICP plateau waves.
Insomnia, Anxiety, and Depression Symptoms during the COVID-19 Pandemic May Depend on the Pre-Existent Health Status Rather than the Profession
Authors: Wańkowicz Paweł , Szylińska Aleksandra , Rotter Iwona
Published: July 2021

Despite the high number of studies on mental health among healthcare workers, only a few have attempted to assess the mental health of people with chronic diseases during the COVID-19 crisis. Therefore, the aim of this study is to evaluate the symptoms of insomnia, anxiety, and depression among people with chronic diseases working in healthcare and in other professions. The study participants were divided into two groups. The first group consisted of 441 healthcare workers, and the second consisted of 572 non-healthcare professionals. Correlation analysis showed a strong correlation between autoimmune diseases and an increase in GAD-7 scale, ISI score, and PHQ-9 scale. Therefore, only autoimmune diseases were included for further analyses as a predictor of insomnia, depression, and anxiety. After adjusting the results for gender, age, smoking, dyslipidemia, hypertension, and profession, the group with autoimmune diseases showed a more than a 2-fold increase in the risk of anxiety symptoms, a more than 2.5-fold increase in the risk of depressive symptoms, and a 4-fold increase in the risk of insomnia symptoms. This study shows that, during the COVID-19 pandemic, the incidence of insomnia, anxiety disorders, and depressive disorders may depend on the pre-existent health status of an individual rather than on their profession.
Assessment of Summer Overheating in Concrete Block and Cross Laminated Timber Office Buildings in the Severe Cold and Cold Regions of China
Authors: Dong Yu , Wang Rong , Xue Jing , Shao Jingran , Guo Haibo
Published: July 2021

The aims of the paper were to clarify whether office buildings in the severe cold and cold regions are overheating, especially those with natural ventilation, and whether potential overheating is related to the building materials. The severe cold and cold regions of China were considered to be cool regions during summer. However, with global warming, improvements in the thermal performance of the building envelope and the urban heat island effect, office buildings in these regions are showing different degrees of overheating during summer. Two office building materials commonly used in this area, cross laminated timber (CLT) and concrete block, were simulated in this study. With reference to the overheating standard, the degree of overheating in six cities in the severe cold and cold regions was quantitatively analysed and the extent of overheating for the two building materials was compared. Finally, the influence of thermal insulation on building overheating is discussed, and some suggestions are put forward to improve the relevant national regulations in China. The results show that office buildings in the severe cold and cold regions experience overheating during summer, and CLT buildings are more prone to overheating than concrete buildings during summer. This is attributable to the different thermal mass of the materials. Thick insulation does increase the risk of building overheating, and the effect on concrete buildings is more pronounced. Concrete buildings with an insulation layer can experience overheating for 27–71 h more than buildings without an insulation layer. Insulation on CLT buildings only results in an increase of 11–37 h. When considering the current situation with summer overheating in the severe cold and cold regions, relevant codes should also be modified and improved accordingly to guide building design, so as to achieve low-carbon and energy-saving goals.