bluuebunny/crossref_metadata_2025 huggingface dataset:
Large-scale deep learning analysis for the early diagnosis of primary immunodeficiencies
Authors: Papanastasiou Giorgos , Yang Guang , Fotiadis Dimitris , Dikaios Nikolaos , Wang Chengjia , Huda Ahsan , Sobolevsky Luba , Sidhu Gurinder , Palumbo Donna
Published: December 2022

Primary immunodeficiency (PID) is a group of heterogeneous disorders resulting from immune system defects. The early PID diagnosis is compromised by the heterogeneous manifestations along with low clinical awareness. Most PID cases are significantly underdiagnosed leading to increased mortality, co-morbidities and healthcare visits and costs. Among PID, combined immunodeficiencies (CID) are characterized by complex immune defects. Common variable immunodeficiency (CVID) is among the most common types of PID. In light of available treatments for CID and CVID, it is critical to systematize their early diagnosis. Our study objectives were two-fold. First, we developed and evaluated an accurate deep learning model to analyze administrative medical claims data from EHRs towards systematizing screening and early identification of CID and CVID. Second, we revealed the most important CID- and CVID-associated clinical phenotypes and their combinations, demonstrating a systematic methodology to improve early identification of these PID. All data were composed of medical claims derived from the Optum® de-identified electronic health record (EHR) database. Four large cohorts were generated: 797, 797, 2,312, and 19,924 CID/CVID cases and equal control sizes in Cohorts 1–4, respectively (a total of 47,660 cases and controls). Two deep learning models were developed (TabMLPNet and TabResNet) and compared against baseline models. Univariate logistic regression was used to calculate odds ratios across all clinical phenotypes and their combinations. The TabMLPNet model showed the highest diagnostic performance across cohorts with sensitivity, specificity, and overall accuracy ranging from 0.82–0.88, 0.82–0.85, and 0.80–0.87, respectively. For the first time, we identified distinctive combinations of antecedent phenotypes associated with CID/CVID per cohort, being consisted of respiratory infections/conditions, genetic anomalies, cardiac defects, autoimmune diseases, blood disorders and malignancies. Most phenotypes emerged were well described in the literature, which validated our findings. Moreover, several less well documented individual phenotypes (i.e., asthma, coagulation defects complicating pregnancy, cancer of lymphoid histiocytic tissue, lymphoid leukemia chronic) were also identified, which can lead to better clinical surveillance of PID. We demonstrated a generalized and accurate method evaluated on a large EHR-derived cohort of CID/CVID cases and controls. Our methodology can lead to the development of new clinical guidelines and pathways for earlier identification of the most important antecedent phenotypes and their combinations, enhance clinical awareness and be used to improve PID diagnosis and outcomes on a population level.
Various forms of programmed cell death, including apoptosis and regulated necrosis, are concurrently activated in retinal ganglion cells after ischemia and reperfusion
Authors: Dvoriantchikova Galina , Adis Emily Victoria , Lypka Karin Rose , Ivanov Dmitry
Published: December 2022

Retinal ischemia–reperfusion (IR) injury – the ultimate consequence of which is retinal ganglion cell (RGC) death – is a common cause of visual impairment and blindness worldwide, largely due to rather ineffective treatments. A special role here belongs to various forms of programmed cell death (PCD), since they can be prevented by inhibiting the activity of the corresponding signaling cascades. To study the PCD pathways in ischemic RGCs, we used a mouse model of retinal IR and a variety of approaches including high-throughput expression profiling (RNA-seq), animals with reduced expression of target genes (FAS and TNFR1/Tnfrsf1a deficient mice), and animals treated with the oral iron chelator deferiprone (1 mg/ml in the drinking water). In our RNA-seq analysis, we utilized RGCs isolated from ischemic and control retinas 24 hours after reperfusion using the two-step immunopanning protocol. Our RNA-seq analysis has shown increased expression in ischemic RGCs compared to control RGCs of many genes that regulate (e.g., Tlr4, Ticam1, Zbp1, Tnfrsf1a, Tnfrsf10b, Fas) or are directly involved in such types of PCD as apoptosis (e.g., Bid, Bcl2l11, Bak1, Hrk, Casp8), necroptosis (Ripk1, Ripk3, Mlkl), pyroptosis (e.g., Pycard, and Casp1), oxytosis/ferroptosis (e.g., Acsl5, Ftl1, Hmox1, Lpcat3, Slc39a14, Steap3), and parthanatos (Parp1). These data indicate that multiple types of PCD are active simultaneously in ischemic RGCs. We found that genetic ablation of death receptors (TNFR1 and FAS) protects RGCs from retinal IR. Our data indicate that the signaling cascades that regulate ferrous iron (Fe2+) metabolism undergo significant changes in ischemic RGCs, leading to retinal damage after IR. All this data set allows us to assume that activation of death receptors and toll-like receptors on the surface of ischemic RGCs, increased ferrous iron (Fe2+) production in these neurons may be responsible for the simultaneous triggering of apoptosis, necroptosis, pyroptosis, oxytosis/ferroptosis, and parthanatos. Thus, therapy is needed that could concurrently regulate the activity of the multiple PCD pathways to significantly reduce RGC death after IR.
Axiological Culture of a Journalist in the Digital Era
Authors:   Transbaikal State University, Erofeeva Irina V. , Safronova Olga V. ,   Transbaikal State University
Published: December 2022

The values of modern journalism are directly related to the era of a special informational narrative conditioned by ratings and the economic factor combined with the dominant information technology and the current confrontation between the traditional and the new. The research results are based on data from a three-stage survey conducted in 2018–2022 with the participation of more than 240 journalists of the Transbaikal Region and other regions of Russia aged 18 to 75.The survey was focused on identifying the civil, ethical and spiritual-moral views of journalists, the dominant axiological strategies of professional activity, determining the role of moral guidelines in the professional consciousness of the journalistic community and the specifi cs of ethical norms’ infl uence on the daily work of a journalist. The purpose of this article is to present a characteristic of a journalist’s axiological culture in the digital era, to identify the value dominants of his professional activity, determining their signifi cance, meaning and levels of experience, based on the conducted sociological survey. The research has been conducted within the framework of the linguocultural approach, which emphasizes the unity of culture and language in the process of creating and perceiving a media text, as well as the sociocultural approach, focused on the integrative potential of the media and the translation of values, which contribute to national identity. The article offers a defi nition of the “axiological culture of a journalist” as a hierarchical system of professional values, refl ecting unifi ed and socially signifi cant ideals and meanings, normative bases for acts of consciousness and behavior that provide the context for the journalist’s interpretation of reality and organize reality through an evaluative implication. The results of the sociological study have made it possible to identify the causes and conditions of professional ethics violations by journalists. The predominant motivations for informational interaction are formulated, value priorities in journalists’ work are identifi ed, and typical cultural markers demonstrating the actualization of memories in the “past-present-future” paradigm are singled out. The present article is the fi rst experience of systematization of the integral system of journalistic axiological culture on the basis of sociological material, which implies further interdisciplinary research of this issue.
KukArt Magazine as a Cultural Project
Authors:   Udmurt State University, Zvereva Tatyana V.
Published: December 2022

The present research raises a question on functioning of magazines in the digital era. The author of the paper addresses the KukArt magazine (1992–2006) which used to be a hallmark in the Russian intellectual life at the turn of the century and has not lost its relevance at present. The research proposes a discursive analysis to identify features of the KukArt magazine strategy. According to the author of the paper, the KukArt longevity phenomenon can be explained by the fact that the magazine became a testing ground to try some mutually exclusive ideas, and the place where different discourse practices coexisted. The article formulates the idea that the purpose of the magazine was to form a new cultural space which synthesizes various fi elds of art. The author gives a detailed description of all issues of the magazine in the synchronous and diachronic aspects. The main feature of KukArt is absence of a unifi ed framework (making features which were based on objectives set and problems solved: the puppet and the avant-garde, the puppet and literature, the puppet and folklore, the puppet and the masquerade mask, the puppet and home theatre, the puppet and the mannequin, etc.) Originally targeted at the puppet, the magazine shifted gradually towards an anthropological pole trying to answer the question: ‘What is a human?’ Due to such an editorial strategy KukArt drew a wide reading audience attention and went beyond theatre environment bounds. Limited edition and absence of a digital format led to the rise of the magazine ‘aura value’, for the unique and non-reproducible things only have had the greatest value in human culture system.
Hypertext as a Form of Artistic Refl ection of Reality in the Digitalization Era
Authors:   Transbaikal State University, Zeynalova Ksenia V.
Published: December 2022

The article considers hypertext as a form of artistic refl ection of reality that emerged at the end of the twentieth century, where individualization and computer technologies come to the fore. Initially, the concept of “hypertext” was used in the fi eld of programming. However, the concept of “branching” turned out to be promising, and researchers started talking about hypertext literature. In this regard, the purpose of the study is to consider hypertext as a form of artistic refl ection of reality in the era of digitalization. The article uses the following literary methods: cultural-historical, phenomenological, the method of structural analysis of the text. The scientifi c novelty of the research is determined by the need to determine the patterns of development of hypertext literature and to identify its specifi cs. The article reveals the main features of literary hypertext: non-linearity, fragmentation, multi-authorship, interactivity. In addition, we can see how the form of interaction with the text is changing: there is no traditional paradigm of “author – text – reader” in front of us. Bakhtin’s concept of dialogue is replaced by R. Barth’s idea of the author’s death. Hypertext literature builds a new way of interacting with the text, in which the reader takes the place of the author. The theoretical provisions of the work were confi rmed by the analysis and evaluation of foreign and Russian hypernovels. The article also suggests that the main reason for the collapse of the traditional linear narrative in literature is social atomization, which inevitably leads to the disappearance of genuine dialogue in the modern world. The results of the study can be used in the study of the culture of the era of digitalization. In addition, the identifi cation of examples of genuine dialogism associated with the reader’s understanding of the author’s idea in the works of electronic hypertext literature, intertextual references to other texts as a way of semantic increment and not the implementation of a purely game strategy seems quite promising for the complex of sciences involved in the identifi cation of meanings in modern culture: philosophy, literary studies, semiotics, cultural studies.
Networked Language Communities: From Constructed Languages to Natural Languages
Authors:   Khakass State University, Chistanov Marat N.
Published: December 2022

Activities for the preservation and development of ethnic minority languages are considered as the most important part of the actions to preserve the cultural heritage of the peoples inhabiting the Russian Federation. The obligatory nature of such activities is enshrined in our country constitutionally. For the ethnic intelligentsia, any attempts to infringe on the linguistic rights of their peoples turn out to be very painful. This problem in domestic science is most often considered in the tradition of linguistic relativism. This approach comes from the Humboldtian tradition in linguistics and in modern practice is associated with the Sapir-Whorf hypothesis. With all the advantages of this approach, it is not without a number of disadvantages. The theory of a unique linguistic world view leads to the sacralization of the language, conserving and ritualizing it, depriving it of vitality. The situation with the functioning of regional languages will change either with the revitalization of old language communities, or with the formation of new language communities in which the language can function as a real means of communication and will gain a new lease on life. Accepting the fact that it is hardly possible to return to traditional economic systems in which the languages of ethnic minorities were rooted, it seems interesting to study the experience of the functioning of communities of modern artifi cial languages. The network forms of organization of such communities are interesting, because in the context of globalization, the emergence and functioning of local linguistic communities based on a geographical principle becomes diffi cult. This turn makes us take a different look at the problems of the functioning of natural and artifi cial languages: it is not its internal structure, semantics and syntactics that comes to the fore but the conditions for its use and the reasons that make people turn to it, that is, pragmatics. In other words, the problem of the viability of a language is not so much a question of its morphology and syntax, and not even a question of its expressive possibilities and means, but a question of the motives of people’s linguistic behavior.
Limitations of Smithian Sympathy: Smith’s Social Sympathy and Wordsworth’s Unreadable City
Authors:   British And American Language And Literature Association Of Korea, Shin Sung Jin
Published: December 2022

In The Theory of Moral Sentiments (1759), Adam Smith suggests an important theory about moral sentiments that influenced many contemporary writers. While some praised Smith’s original theory of moral sentiments that emphasized the importance of society, others have been more skeptical about the workings of Smithian sympathy. In this essay, I first explore the primary elements of Smith’s theory that make it unique and significant. Then, I turn to the evaluation of Smithian sympathy by another important thinker in the early nineteenth century, the Romantic poet William Wordsworth. Wordsworth evaluates the workings of Smithian sympathy in his portrayal of London in Book Seventh of The Prelude (1805), where the emerging city of London serves as a counterexample to the mechanism of Smithian sympathy as the London society fails to work as a mirror for its members. The examination of Book Seventh of The Prelude will not only illuminate the flaws in the Smithian scheme of sympathy but also highlight Wordsworth’s insights on the subject as well as his corrections to Smith’s system.
USABILIDADE APLICADA AOS SISTEMAS M-LEARNING: ANÁLISE DE DISPOSITIVOS MÓVEIS COMO FERRAMENTA DE ENSINO
Authors: Nunes Tolentino Costa Karolina , Anthero Nunes Vianna dos Santos Flávio
Published: December 2022

O presente estudo, fruto de uma dissertação produzida no curso de mestrado em Design, propõe avaliar a interação entre estudantes e dispositivos móveis sob a ótica da Usabilidade, buscando averiguar os principais problemas de uso inseridos no contexto educacional. O método utilizado divide-se em três etapas: Revisão Bibliográfica, que explora as especificidades, conceitos e teorias aplicados a este domínio. Coleta de Dados, realizada com oito participantes, sendo cinco estudantes de curso pré-vestibular (público-alvo) e três especialistas na área de usabilidade móvel, convidados a contribuir com o estudo por meio de pareceres técnicos sobre usabilidade. A amostra de estudantes foi submetida a simulações de atividades educacionais nas interfaces da plataforma móvel de aprendizagem AppProva, por onde se tornou possível investigar a satisfação do usuário em relação à navegabilidade do sistema, engajamento de atividades, padronização e consistência de elementos visuais e liberdade de controle na plataforma. Por fim, realiza-se a análise dos resultados encontrados, apurando as principais complexidades e limitações presentes no m-learning, sendo estas: isolamento do aluno, baixa autonomia da bateria, instabilidade de conexão com a internet, esforço excessivo da visão, distrações e interferências virtuais, barreiras de acessibilidade e dificuldade para corrigir erros apresentados pelo sistema.
REFLEXÕES TEÓRICAS SOBRE ENSINO DE FÍSICA: UMA ABORDAGEM FILOSÓFICA
Authors: Santos Carlos Alberto Andrade Serra dos , Freitas Gisele Bosso de , Façanha Filho Pedro de Freitas
Published: December 2022

Este trabalho propõe uma reflexão acerca do ensino de Física, seja na educação básica ou superior, considerando a Filosofia da Ciência, na tese de Gaston Bachelard, como prática pedagógica e associando-a ao paradigma específico do professor reflexivo, proposto por Donald Schön. Trata-se de um estudo teórico-reflexivo de natureza exploratória com abordagem qualitativa, que enxerga a Física além do ensino de suas teorias e práticas experimentais. Desse modo, idealiza-se que o ensino de Física possa promover discussões acerca do funcionamento da Ciência e sua interação com as diferentes áreas do conhecimento humano, assim como suas implicações na sociedade. Para isso, considera-se então, a questão da formação de profissionais reflexivos que, no que se trata especificamente da formação de discentes de cursos de Licenciatura em Física, possam contribuir para um processo de ensino-aprendizagem mais amplo e inter-relacionado com a vida cotidiana e no que diz respeito aos estudantes do Ensino Médio, que possam compreender a contribuição da ciência para a geração de tecnologias que impactam a sociedade e perceber seu papel diante desse contexto.
Causes of Reduced Revenue Generation in Federal Staff Hospital (Fsh) Laboratory; Annex 111 Federal Capital Territory, Abuja
Authors: M G Bassey
Published: December 2022

The healthcare delivery system has been criticized for its “culture of blame” in which culpability for failure has been attributed to the human elements of the system: The Study was designed to identify and ascertain reasons for low-revenue generation in Federal staff hospital (FSH) laboratory; annex 111, Abuja and to proffer solutions, as well as deliver health care that minimizes risks and harm to service users, including avoiding preventable injuries and reducing medical errors. According to World Health Organization (WHO), a well-functioning healthcare system requires a financing mechanism, well trained and adequately paid workforce, reliable Information on which to base decisions and policies, and well-maintained health facilities to deliver quality services and technologies. Out of a total number of two hundred (200) respondents interviewed using questionnaires, hundred and sixty (160) were received using the random sampling method. 41% of the respondents believed that there are no barriers to accessing the facility, 48.0% indicated a Lack of Knowledge, and 11.0% said proximity. The year 2017/2018 to 2019 report showed a tremendous improvement. Revenue generated and the number of patients for the year 2018 was to the tune of twenty-nine million, nine hundred and seventy-six thousand, six hundred and sixty naira only (₦29,976,660.00) and twelve thousand, seven hundred and twenty-six patients (12,726) respectively. In comparing the year 2017/2018, respectively, this Study concluded that for overall improvement of the quality and performance in the healthcare environment, there is a need for the development of new inter-organizational patterns of care delivery and complex multitier governance structures. Keywords: Federal staff hospital (FSH) laboratory, Health care, Knowledge. Preventable injuries, World Health Organization (WHO).
Utilization of Community-Based Health Insurance among Residence of Katsina State, Nigeria
Authors: Suleiman Yahaya Shamsuddeen
Published: December 2022

Enrollment Into Any Form Of Insurance Is Very Low In Katsina State, With Most People Paying Out Of Pocket For Health Care. The Utilization Of Community-Based Health Insurance Will Provide Financial Risk Protection And Improve Health Outcomes. The Objective Of The Study Is To Compare Differences In Utilization Between Community-Based Health Insurance Member Households And Non-Member Households And To Identify Factors Associated With The Utilization. A Comparative Cross-Sectional Descriptive Study Was Conducted Among Household Heads In Katsina State, Nigeria. Targeted Participants Were Selected Using Multistage Sampling Techniques. Primary Data Was Generated Using Open Data Kit (ODK), Which Was Later Downloaded And Exported To SPSS Version 20® For Statistical Analysis. Mean, And Standard Deviation From The Mean (Mean ± SD) Were Used To Study Population Characteristics Towards Utilization Of CHI. The Statistical Significance Level Of Analyzed Variables Were Accepted At P≤0.05. The Mean Age Of Respondents Was 46.82±13 And 44±12.5 Years For CBHI Enrolled And Non-Ensured Groups, Respectively. Heads Of The Households Were Predominantly Males And Currently Married, With 97.3% And 93.3% For CBHI Members Compared To 82.7% And 99.3% Of Non-Member Households, Respectively. The Enrolled CBHI Group Utilizes PHC Services More Than The Non-Enrolled Group(P<0.05) With Age, Marital Status, Education, Number Of Children, And Distance To Health Facilities All Associated With Utilization. Utilization Of CBHI Was Higher Among Enrolled Groups Than Non-Enrolled Groups. Many Factors, Such As Age, Marital Status, Education Level, And Payment Of Transportation To The Facility, Affect Utilization Of These Services. We Recommend CBHI Be Expanded, Poor And Vulnerable Groups Are Given Special Consideration, And People Not Enrolled Should Be Encouraged To Join. Keywords: Community, Comparative, Health, Insurance, Utilization.
A Reappraisal of Various Animal Models used in Periodontology with Future Perspectives and Alternatives
Authors: Parveen Sameena
Published: December 2022

Periodontitis is an inflammatory infectious disease that occurs when the supporting tissues of the teeth are infected by a mix of gram-positive bacteria (GPB), and anaerobic bacteria. Periodontitis must be treated as soon as possible to avoid more injury and worsening of the condition. Prior to evaluating new treatments, animal studies are used in conjunction with in vitro studies in periodontitis research. Even though cultured cells can be used to examine physiological processes that occur in periodontitis development, the complex host response that is at the root of the illness is impossible to replicate in vitro. Mice, rats, rabbits, hamsters, nonhuman primates, dogs, and pigs have all been used to imitate human periodontitis, each with its own set of benefits and drawbacks. Animals have played an important part in researching periodontal diseases and developing effective treatments. There is a limitation in the usage of large animals due to their housing problems. Animals for periodontitis are selected based on their resemblance with that human structure and functioning. The usage of these animals will aid in the better and more precise replication of human disease. This will improve the disease’s prognosis and treatment outcome. As a result, the medications utilized can provide a better indication of the effect they will have on the human body based on the effects they have on animal models. Therefore, it is critical to use appropriate animals in periodontal research in order to develop improved treatments for these disorders. Thus, animal models play a crucial role in periodontal research. Keywords: Animal models; Bacteria; In vitro; Periodontitis; Treatment.
Prevalence of Worm Infestation and Associated Risk Factors among Rural and Urban Lower Primary School Going Children in Kasama District, Northern Province, Zambia
Authors: Mutale Ernest Chama
Published: December 2022

Regardless of the many health promotion communications and public health interventions that the Government of the Republic of Zambia continues to provide to its citizens via the Ministry of Health that are directed at the prevention and reduction of worm infestation in Kasama District, Northern Province of Zambia, a lot of lower primary school going children still continue to miss school attendance in order to access health services due to worm infestation cases which have continued to be on the increase in both rural and urban areas. The high levels of poverty and other related risk factors in such resource-limited areas have put many of these children at increased risk of worm infestation. Thus, this study investigated the relationship between those risk factors and the prevalence of worm infestation in both rural and urban areas with respect to area of residency of the children. The study used retrospective quantitative methods in eliciting information from data sources from six health facilities in Northern Province covering a 2year period (2018-2020). Consequently, 120 children were identified and included in the study. Thereafter, data were analyzed using a statistical package for the social sciences (SPSS v19). Findings indicate; low socio-economic status and areas of residency were the main contributing risk factors in rural than urban areas. Therefore, recommendations on the country’s policies towards mass deworming programs and basic hygiene in lower primary school going children were availed to government after completing the study. Keywords: Residency, Primary School Children, Prevalence, Worm Infestations, Zambia.
Assessment of Injection Safety Practice in Health Care Settings: a Case from the Gambia
Authors: Ninson Robert
Published: December 2022

Unsafe injection practices transmit bloodborne pathogens on a large scale worldwide and thus the Ministry of Health was assisted in conducting an assessment of injection safety in the Gambia in 2021. Interviews and observation of injection practices in all of the public health facilities and a sample of private health facilities including NGO. A total of 81 health facilities had been involved. Sterilisation of injection material observed in 3 facilities (3.7%) for therapeutic injection. Vaccinations, used either AD syringe (83.7%) or disposable syringes (16.3%). Re-used injection equipment without sterilisation in facilities was 8.6%. Proportion of health facilities in lack of AD syringes is 6.3%. 87.3% of the health facilities the availability of AD syringes was over than 50 units. Lack of disposable syringes was 17.3% of the health facilities. In 46 health facilities (56.8%), the availability of disposable syringes was over 20 units. Lack of safety box in facilities was 50.6% (n=41). Needle stick injuries have been observed in 79.7% (n=74) of the health facilities. A proportion of 70.9% of vaccinators and 52.1% of curative injection providers reported experiencing at least one needle-stick injury. Lack of safety boxes and waste disposable facilities, unsafe behaviours and poor sharp waste management lead to unsafe injection practices in the Gambia, exposing patients, health care workers and community to bloodborne infections. A coordinated strategy, training of health workers, and encouraging of the proper disposal of sharp required to prevent injection-associated infections in the Gambia. Keywords: AD syringes, Injection, Needles, Safety boxes.
Self-Medication of Prescription Only Non-Steroidal Anti-Inflammatory Drugs among Households in Alimosho LGA, Lagos State, Nigeria
Authors: Afam Dunoi Onwuemezie
Published: December 2022

The purpose of this study is to determine the knowledge, attitude, and practice of self-medication of NSAIDs among adults in Alimosho Local Government Area (LGA) of Lagos State. The study is descriptive inferential form cross-sectional study that involved collection of data from adults in the LGA. The data collected from questionnaires administered to adults who were randomly selected across the LGA was analyzed to evaluate the association between demographic characteristics and knowledge, attitude, and practice of self-medication. The respondents who participated in the research were adults who were 18 years and above. Of the 652 respondents 50.8% were males and while 49.2% were females. Demographic profile and Information sources were tested for association with self-medication. Among respondents, 80.6% admitted that they are self-medicated, and a binary logistic regression was performed to ascertain the effect of gender, age, marital status, and educational attainment on the likelihood of respondents engaging in self-medication. The overall logistic regression was statistically significant, χ2 (1) = 24.824, p< 0.005. The model explained 10.2% (Nagelkerke R2) of the variance in self-medication and correctly classified 80.4% of cases. Keywords: Alimosho, Attitude, Knowledge, Lagos State, NAFDAC, NSAID, Perception, Self-medication.
The legal system of ukraine among legal systems of the present
Authors: М. Г. Хаустова
Published: December 2022

Based on the analysis of different typologies of legal families it was found that the national legal families it was found that the national legal system of Ukraine should be considered the legal system of the transitional period, striving for Romance and German legal family and being its original associated member. It is justified that the legal system of Ukraine reters to the group of Romance and German legal family of Eastern Europe.
Modernisation measuring of organization and activity of organs of state administration culture
Authors: І. Г. Ігнатченко
Published: December 2022

The necessity of modernisation is grounded by state managements in the field of culture taking into account home and foreign experience. The special attention is sanctified to the search of ways of optimization of processes of forming and realization of public policy in the investigated area.
Internationally - legal facilities of functioning of offshore financial centers
Authors: І. М. Товкун
Published: December 2022

In the article investigated problems that can generate offshore financial centers and events sent to adjusting of activity of such centers. Essence, terms of activity, classification of world offshore financial centers, is considered. Drawn conclusion that Ukraine also must set forth the legal position through this question.
Criminal responsibility for making deliberately unjust sentence, decision, definition or ruling by a judge (judges): analysis of the main corpus delicti
Authors: В. А. Козак
Published: December 2022

The article deals with objective and subjective signs of corpus delicti, presupposed by p. 1 Art. 375 of the CC (making deliberately unjust sentence, decision, definition or ruling by a judge (judges), forms conclusions concerning interpretation of several corresponding provisions of the criminal legislation of Ukraine regarding researched problem.
Definition of the concept use information in the anthropocentric approach
Authors: Д. О. Біленська
Published: December 2022

Definition of the term "information" is analyzed in the concept of substantive approach, benefits are determined and their flaws. The author's interpretation of this category.
Legal and economic grounds of conclusion agreements about creation of IMF
Authors: С. Г. Фіннік
Published: December 2022

The complex of legal and economic pre-conditions of conclusion of IMF treaty is examined in the article. It is underlined that Fund was created as organization on collaboration between the states with a purpose of adjusting of the international currency system.
Trends in the development of law in the context of globalization
Authors: М. Г. Хаустова
Published: December 2022

The article substantiales that for the profound understanding of law that the exists in terms of globalization, is important to identify the main trends of its development. This allows to establish the current state of law, and also to outline the general direction of the development of law in the future.
Some theoretical questions about the nature of ukrainian constitutionalism after 1991
Authors: С. Ю. Лукаш
Published: December 2022

The attempt to research the nature of Ukrainian constitutionalism after 1991, which consists of three levels: social interest, constitutional model, quality of a person on the basis of using of the research method system including integral, systematic, systematic analysis, consideration of all internal and external variables is taken in this article.
In search of an optimal model of fixing administrative responsibility in the sphere of housing and communal services
Authors: О. Є. Кущ
Published: December 2022

The article describes the various options for fixing the administrative responsibility for housing and communal services in different countries. The basic model of such a fixation. On the basis of theory and practical experience suggested an optimal model for Ukraine.
The essence and significance of the preparatory process in the criminal proceedings: a national and international legal aspects
Authors: Ю. В. Лисюк
Published: December 2022

The article is devoted to the issues of the preparatory stages of production in the criminal process. The characteristic of a preparatory essence of production as a separate stage of the criminal proceedings. Determine the value of production in the course of preparatory proceedings in the first instance. Conducted a separate analysis of national and international legislation regarding this issue.
The reasonableness among the rule-making principles
Authors: К. О. Мандрікова
Published: December 2022

The article describes the principles on which the process of creation of the law is based. The role of reasonableness as rule-making requirement is explained.
Kinds of founding documents of legal entities
Authors: Т. І. Бровченко
Published: December 2022

The article is devoted to kinds of founding documents of legal entities, their variety and peculiarities. It is considered the meaning of founding documents, and the connection between them and the status of certain formation as an artificial person. It is stressed on special activity features of the legal entity according to its model charter.
Media competence of prosecutor: formulation of the question
Authors: Г. В. Гаврюшенко
Published: December 2022

The problems of implementation of the Prosecutor's Office of Ukraine professional approaches to cooperation with the media communication by increasing media competence prosecutors. Defined the legal nature, the main components of this phenomenon and reveals the method of forming the so-called "Media card". Focused on the necessity of monitoring the development of the media and media strategy in the prosecution.
Combined method of renal denervation in an animal model
Authors: Bashta D.I. , Vilenskiy L.I. , Krivosheev Yu.S. , Simonyan A.A. , Romanov A.B.
Published: December 2022

Background: Currently, intra-arterial radiofrequency renal denervation is an only interventional treatment for resistant hypertension. However, available data are controversial since this method does not provide the long-term hypotensive effect.Objective: To compare the safety and efficacy of laparoscopic mechanical renal denervation and laparoscopic combined renal denervation using a radiofrequency clamp.Methods: Thirty sheep weighing 93.00 ± 3.72 kg were divided into two groups for mechanical laparoscopic renal denervation (group I, n = 15) and combined laparoscopic renal denervation with a radiofrequency clamp (group II, n = 15). The observation period lasted for six months. We assessed the following parameters: blood pressure (BP) in response to high-frequency electric stimulation from the lumen of the vessel, creatinine and uric acid levels, iatrogenic damage to the renal arteries based on angiography findings, and destruction of nerve fibers based on histological findings.Results: All the animals survived throughout the observation period. Creatinine and uric acid levels were within the normal ranges. Renal angiography did not reveal any iatrogenic stenosis. After six months, we found some BP response (elevated systolic BP ∆66.73 ± 6.63 mm Hg [p < 0.001], elevated diastolic BP ∆47.27 ± 5.98 mm Hg [p < 0.001]) to high-frequency electric stimulation in group I and no hypertensive response in group II. After six months, the animals were withdrawn for further histological assessment. Histology revealed complete destruction of the nerve fiber (demyelination) in group II and vacuolized swollen nerve fibers without any signs of demyelination in group I.Conclusion: Laparoscopic combined renal denervation is a safe and efficacious method with a stable hypotensive effect after six months in an animal model as compared to laparoscopic mechanical renal denervation.
Received 30 March 2022. Revised 5 December 2022. Accepted 9 December 2022.
Funding: The study did not have sponsorship.
Conflict of interest: Authors declare no conflict of interest.
Contribution of the authorsConception and study design: D.I. Bashta, L.I. Vilenskiy, A.B. RomanovData collection and analysis: D.I. Bashta, Yu.S. Krivosheev, A.A. SimonyanStatistical analysis: D.I. Bashta, Yu.S. KrivosheevDrafting the article: D.I. Bashta, Yu.S. Krivosheev Critical revision of the article: L.I. Vilenskiy, Yu.S. Krivosheev, A.B. Romanov Final approval of the version to be published: D.I. Bashta, L.I. Vilenskiy, Yu.S. Krivosheev, A.A. Simonyan, A.B. Romanov
Sekularyzm i wielokulturowość – wzajemnie połączone wyzwania polityczne
Authors: Modood Tariq
Published: December 2022

Istnieje szereg powodów, by raz jeszcze przemyśleć sekularyzm polityczny. Najbardziej znaczącym z nich jest wyzwanie wielokulturowości, z którym mierzy się Europa Zachodnia. Państwa zachodnioeuropejskie są obecnie bardzo skoncentrowane na wyzwaniach wynikających z różnorodności etniczno-religijnej będącej następstwem imigracji. Nowe osiedla muzułmańskie powstałe na przestrzeni ostatnich pięćdziesięciu lat znajdują się w samym centrum tego problemu. Okoliczności te zmuszają do nowego sposobu myślenia, nie tylko o kwestiach integracji społecznej, ale także o roli religii w odniesieniu do państwa i obywatelstwa. Fundamentalna kwestia, którą wielu uważało za dawno rozstrzygniętą, wyłania się ponownie z nową siłą i budzi nowe kontrowersje – jest nią sekularyzm polityczny, szczególnie w kontekście tolerancji, uznania i zarządzania. Autor niniejszego artykułu twierdzi, że postsekularyzm czy kryzys sekularyzmu mają w Europie Zachodniej dość zasadniczy związek z rzeczywistością wielokulturowości.
Narody Zjednoczone, Stolica Apostolska i „globalny reset”
Authors: Adolphe Jane
Published: December 2022

Celem niniejszego opracowania jest przyjrzenie się stanowisku Stolicy Apostolskiej w  sprawie „globalnego resetu” poprzez analizę jej kluczowych wypowiedzi i działań w odniesieniu do Światowego Forum Ekonomicznego (WEF), będącego organizacją pozarządową (NGO), oraz Organizacji Narodów Zjednoczonych (ONZ), będącej organizacją międzyrządową. Artykuł został podzielony na trzy części. W  części pierwszej zdefiniowano pojęcia i przedstawiono tło dyskusji. W części drugiej omówiono i  poddano krytyce prace Klausa Schwaba, przewodniczącego Światowego Forum Ekonomicznego (WEF), który postrzega COVID-19 jako impuls do rozpoczęcia procesu określanego przez niego mianem „globalnego resetu”. Część trzecia zawiera przegląd obecnych działań Stolicy Apostolskiej w ramach systemu ONZ, które wydają się ściśle powiązane z inicjatywami WEF dotyczącymi globalnego resetu. Rozważane są zarówno uzasadnienia stanowiska Stolicy Apostolskiej, jak i głosy krytyczne wobec niego. Artykuł stwierdza, że Stolica Apostolska przyjęła pewne inicjatywy globalnego resetu i celowo używa języka podobnego do tego, którym posługuje się WEF, jednocześnie utrzymując, że jej podejście jest ugruntowane w Piśmie Świętym i stanowi roztropne zastosowanie społecznej doktryny Kościoła. Nie wszyscy zgadzają się z taką oceną.
Lewicowa ofensywa w Unii Europejskiej
Authors: Grosse Tomasz Grzegorz
Published: December 2022

Artykuł ma trzy główne cele badawcze. Po pierwsze, pokazać założenia strategii proponowanej przez myślicieli lewicowych pod koniec XX wieku. Po drugie, założenia teoretyczne i filozoficzne tej strategii zostaną skonfrontowane z praktyką funkcjonowania ugrupowań lewicowych w Parlamencie Europejskim i innych instytucjach UE, zwłaszcza po wybuchu kryzysu w strefie euro po roku 2010. Po trzecie, wcześniejsze rozważania zostaną podsumowane z perspektywy globalnej i europejskiej. Celem artykułu jest odpowiedź na pytanie, czy ofensywa lewicy widoczna w UE w drugiej dekadzie XXI wieku może przyczynić się do sukcesu tej formacji oraz do uzdrowienia projektu europejskiego.
Faith Based Organizations as Instigators of Development: the contribution of Alfagems Secondary School in Morogoro (Tanzania)
Authors: Jarosz Tadeusz , Komba Emmanuel
Published: December 2022

The study attempts to capture the impact of the religious element upon the development of a developing country. Due to the range of difficulties in outlining the field of study, from the outset it was assumed that the pro-developmental activity of Faith-Based Organizations (FBO) is carried out as an immanent part of the socio-economic processes of development. As FBO insiders target a given developmental goal, they start to act upon the secular proponents which are continually being reinforced from within the religious dimension. As indicated, this leads to measurable goals (the results of state examinations).
Amerika Birleşik Devletleri’nde Ermeni Diasporası [1890-1915]
Authors: Özkan Selim Hilmi
Published: December 2022

Uzun yıllar Türkler ile aynı coğrafyada huzur ve barış içerisinde yaşayan Ermeniler, 19. yüzyılda kısmen kendi istekleri, kısmen diğer devletlerin teşviki, kısmen diaspora Ermenilerinin baskısı ile başta Amerika Birleşik Devletleri olmak üzere yurtdışına göç etmeye başladılar. Bu göç nedenlerini de Osmanlı Devleti’nin siyasi baskısına bağladılar. Fakat Osmanlı Devleti bu süreçte kendi vatandaşı olarak gördüğü ne Ermenilerin, ne diğer Hristiyan grupların ne de Müslümanların göçmesinden yanaydı. Fakat tüm tedbirlere rağmen 19. yüzyılın ikinci yarısı ve 20. yüzyılın başlarında göç hadisesi yoğun bir şekilde devam etti. Göç sonrası Amerika Birleşik Devletleri’ne göç eden Ermeniler, burada oluşturdukları kolonileri ile milli benliklerini korumaya çalıştı. Fakat bu benlik korumada Osmanlı ve Türk düşmanlığı yapmayı ortak hedef olarak belirlediler. Bilhassa diasporanın oluşmaya başlaması ile yerel ve ulusal basında Türklük ve Osmanlı aleyhine sayısız yazı çıkmıştır. Bu haberlerin birçoğu gerçeklikten uzak tamamen Ermeni ve büyük devletlerin çıkarlarına hizmet etmek için ve onların yönlendirmesi ile yapılmıştır.
Bu çalışmamızda Osmanlı Arşiv Belgelerinin yanı sıra Amerika Birleşik Devletleri’nde 1777-1963 yılları arasında yayın yapan ve dijital ortama aktarılan 19.717.204 sayfalık gazete arşivinden 1890-1915 yılları arası anahtar kelimeler üzerinden taranmıştır. Bu bilgiler metin analizi yöntemi ile değerlendirmeye tabi tutulurken konu ile ilgili kitap ve makaleler de incelenmiştir.
Palladium-catalyzed C-N Coupling Reactions in the Synthesis of Dibenzodiazepines
Authors: Grewal Pooja , Kaur Navjeet
Published: December 2022

In today’s world, aryl halides have attracted our attention toward the amination
reactions catalyzed by palladium. In this review article, there are some selected developments
in the field of catalysis, and the Buchwald-Hartwig amination reaction is one of them. It is a
common and highly efficient method reported for forming dibenzodiazepines. The readily
accessible precursors and ammonia undergo cross-coupling reactions in the presence of a palladium
catalyst; after that, the intermediate immediately undergoes intramolecular condensation
to give the desired dibenzodiazepines in one step. Due to the structural characteristics of
these compounds, the potential for diversification - principally for functional group incorporation
- is immense. New and advanced technologies are also employed to form these medicinally
important molecules and are reviewed here. Our purpose is to inform the researchers about
recent advances in this protocol for the C-N bond formation, especially used for synthesizing dibenzodiazepines.
Machine Learning in Drug Metabolism Study
Authors: Sinha Krishnendu , Ghosh Jyotirmoy , Sil Parames Chandra
Published: December 2022

Metabolic reactions in the body transform the administered drug into metabolites. These metabolites exhibit diverse biological activities. Drug metabolism is the major underlying cause of drug overdose-related toxicity, adversative drug effects and the drug’s reduced efficacy. Though metabolic reactions deactivate a drug, drug metabolites are often considered pivotal agents for off-target effects or toxicity. On the other side, in combination drug therapy, one drug may influence another drug’s metabolism and clearance and is thus considered one of the primary causes of drug-drug interactions. Today with the advancement of machine learning, the metabolic fate of a drug candidate can be comprehensively studied throughout the drug development procedure. Naïve Bayes, Logistic Regression, k-Nearest Neighbours, Decision Trees, different Boosting and Ensemble methods, Support Vector Machines and Artificial Neural Network boosted Deep Learning are some machine learning algorithms which are being extensively used in such studies. Such tools are covering several attributes of drug metabolism, with an emphasis on the prediction of drug-drug interactions, drug-target-interactions, clinical drug responses, metabolite predictions, sites of metabolism, etc. These reports are crucial for evaluating metabolic stability and predicting prospective drug-drug interactions, and can help pharmaceutical companies accelerate the drug development process in a less resourcedemanding manner than what in vitro studies offer. It could also help medical practitioners to use combinatorial drug therapy in a more resourceful manner. Also, with the help of the enormous growth of deep learning, traditional fields of computational drug development like molecular interaction fields, molecular docking, quantitative structure-toactivity relationship (QSAR) studies and quantum mechanical simulations are producing results which were unimaginable couple of years back. This review provides a glimpse of a few contextually relevant machine learning algorithms and then focuses on their outcomes in different studies.