bluuebunny/crossref_metadata_2025 huggingface dataset:
Adsorption of vancomycin, gentamycin, ciprofloxacin and tygecycline on the filters in continuous renal replacement therapy circuits: in full blood in vitro study
Authors: Onichimowski Dariusz , Nosek Krzysztof , Ziółkowski Hubert , Jaroszewski Jerzy , Pawlos Aleksandra , Czuczwar Mirosław
Published: October 2020

The aim of this study was to assess the in vitro adsorption of antibiotics: vancomycin, gentamicin, ciprofloxacin and tigecycline on both polyethyleneimine-treated polyacrylonitrile membrane of AN69ST filter and polysulfone membrane of AV1000 filter using porcine blood as a model close to in vivo conditions. The porcine blood with antibiotic dissolved in it was pumped into hemofiltration circuit (with AN69ST or AV1000 filter), ultrafiltration fluid was continuously returned to the reservoir containing blood with antibiotic. Blood samples to determine antibiotic concentrations were taken at minutes 0, 5, 15, 30, 45, 60, 90 and 120 from the pre- blood pump of the hemofiltration circuit. To assess possible spontaneous degradation of the drug in the solution there was an additional reservoir prepared for each antibiotic, containing blood with the drug, which was not connected to the circuit. In the case of vancomycin, ciprofloxacine and tigecycline, a statistically significant decrease in the drug concentration in the hemofiltration circuit in comparison to initial value as well as to the concentrations in the control blood was observed, both for polyacrylonitrile and plolysulfone membrane. In the case of gentamicin, significant adsorption was noted only on polyacrylonitrile membrane. Our studies demonstrated that in full blood adsorption of antibiotics may be big enough to be of clinical significance. In particular in the case of polyacrylonitrile membrane.
Bacillus spores: a review of their properties and inactivation processing technologies
Authors: Cho Won-Il , Chung Myong-Soo
Published: October 2020

Many factors determine the resistance properties of a Bacillus spore to heat, chemical and physical processing, including thick proteinaceous coats, peptidoglycan cortex and low water content, high levels of dipicolinic acid (DPA), and divalent cations in the spore core. Recently, attention has been focused on non-thermal inactivation methods based on high pressure, ultrasonic, high voltage electric fields and cold plasmas for inactivating Bacillus spores associated with deterioration in quality and safety. The important chemical sporicides are glutaraldehyde, chorine-releasing agents, peroxygens, and ethylene oxide. Some food-grade antimicrobial agents exhibit sporostatic and sporicidal activities, such as protamine, polylysine, sodium lactate, essential oils. Surfactants with hydrophilic and hydrophobic properties have been reported to have inactivation activity against spores. The combined treatment of physical and chemical treatment such as heating, UHP (ultra high pressure), PEF (pulsed electric field), UV (ultraviolet), IPL (intense pulsed light) and natural antimicrobial agents can act synergistically and effectively to kill Bacillus spores in the food industry.
The stroke mothership model survived during COVID-19 era: an observational single-center study in Emilia-Romagna, Italy
Authors: Zini Andrea , Romoli Michele , Gentile Mauro , Migliaccio Ludovica , Picoco Cosimo , Dell’Arciprete Oscar , Simonetti Luigi , Naldi Federica , Piccolo Laura , Gordini Giovanni , Tagliatela Francesco , Bua Vincenzo , Cirillo Luigi , Princiotta Ciro , Coniglio Carlo , Descovich Carlo , Cortelli Pietro
Published: October 2020

Introduction

A reduction of the hospitalization and reperfusion treatments was reported during COVID-19 pandemic. However, high variability in results emerged, potentially due to logistic paradigms adopted. Here, we analyze stroke code admissions, hospitalizations, and stroke belt performance for ischemic stroke patients in the metropolitan Bologna region, comparing temporal trends between 2019 and 2020 to define the impact of COVID-19 on the stroke network.

Methods

This retrospective observational study included all people admitted at the Bologna Metropolitan Stroke Center in timeframes 1 March 2019–30 April 2019 (cohort-2019) and 1 March 2020–30 April 2020 (cohort-2020). Diagnosis, treatment strategy, and timing were compared between the two cohorts to define temporal trends.

Results

Overall, 283 patients were admitted to the Stroke Center, with no differences in demographic factors between cohort-2019 and cohort-2020. In cohort-2020, transient ischemic attack (TIA) was significantly less prevalent than 2019 (6.9% vs 14.4%, p = .04). Among 216 ischemic stroke patients, moderate-to-severe stroke was more represented in cohort-2020 (17.8% vs 6.2%, p = .027). Similar proportions of patients underwent reperfusion (45.9% in 2019 vs 53.4% in 2020), although a slight increase in combined treatment was detected (14.4% vs 25.4%, p = .05). Door-to-scan timing was significantly prolonged in 2020 compared with 2019 (28.4 ± 12.6 vs 36.7 ± 14.6, p = .03), although overall timing from stroke to treatment was preserved.

Conclusion

During COVID-19 pandemic, TIA and minor stroke consistently reduced compared to the same timeframe in 2019. Longer stroke-to-call and door-to-scan times, attributable to change in citizen behavior and screening at hospital arrival, did not impact on stroke-to-treatment time. Mothership model might have minimized the effects of the pandemic on the stroke care organization.
A machine learning algorithm supports ultrasound-naïve novices in the acquisition of diagnostic echocardiography loops and provides accurate estimation of LVEF
Authors: Schneider Matthias , Bartko Philipp , Geller Welf , Dannenberg Varius , König Andreas , Binder Christina , Goliasch Georg , Hengstenberg Christian , Binder Thomas
Published: October 2020

Left ventricular ejection fraction (LVEF) is the most important parameter in the assessment of cardiac function. A machine-learning algorithm was trained to guide ultrasound-novices to acquire diagnostic echocardiography images. The artificial intelligence (AI) algorithm then estimates LVEF from the captured apical-4-chamber (AP4), apical-2-chamber (AP2), and parasternal-long-axis (PLAX) loops. We sought to test this algorithm by having first-year medical students without previous ultrasound knowledge scan real patients. Nineteen echo-naïve first-year medical students were trained in the basics of echocardiography by a 2.5 h online video tutorial. Each student then scanned three patients with the help of the AI. Image quality was graded according to the American College of Emergency Physicians scale. If rated as diagnostic quality, the AI calculated LVEF from the acquired loops (monoplane and also a “best-LVEF” considering all views acquired in the particular patient). These LVEF calculations were compared to images of the same patients captured and read by three experts (ground-truth LVEF [GT-EF]). The novices acquired diagnostic-quality images in 33/57 (58%), 49/57 (86%), and 39/57 (68%) patients in the PLAX, AP4, and AP2, respectively. At least one of the three views was obtained in 91% of the attempts. We found an excellent agreement between the machine’s LVEF calculations from images acquired by the novices with the GT-EF (bias of 3.5% ± 5.6 and r = 0.92, p < 0.001 in the “best-LVEF” algorithm). This pilot study shows first evidence that a machine-learning algorithm can guide ultrasound-novices to acquire diagnostic echo loops and provide an automated LVEF calculation that is in agreement with a human expert.
The role of caspase-8 in the tumor microenvironment of ovarian cancer
Authors: Kostova Izabela , Mandal Ranadip , Becker Sven , Strebhardt Klaus
Published: October 2020

Caspase-8 is an aspartate-specific cysteine protease, which is best known for its apoptotic functions. Caspase-8 is placed at central nodes of multiple signal pathways, regulating not only the cell cycle but also the invasive and metastatic cell behavior, the immune cell homeostasis and cytokine production, which are the two major components of the tumor microenvironment (TME). Ovarian cancer often has dysregulated caspase-8 expression, leading to imbalance between its apoptotic and non-apoptotic functions within the tumor and the surrounding milieu. The downregulation of caspase-8 in ovarian cancer seems to be linked to high aggressiveness with chronic inflammation, immunoediting, and immune resistance. Caspase-8 plays therefore an essential role not only in the primary tumor cells but also in the TME by regulating the immune response, B and T lymphocyte activation, and macrophage differentiation and polarization. The switch between M1 and M2 macrophages is possibly associated with changes in the caspase-8 expression. In this review, we are discussing the non-apoptotic functions of caspase-8, highlighting this protein as a modulator of the immune response and the cytokine composition in the TME. Considering the low survival rate among ovarian cancer patients, it is urgently necessary to develop new therapeutic strategies to optimize the response to the standard treatment. The TME is highly heterogenous and provides a variety of opportunities for new drug targets. Given the variety of roles of caspase-8 in the TME, we should focus on this protein in the development of new therapeutic strategies against the TME of ovarian cancer.
Generalized isotopic shift construction for APN functions
Authors: Budaghyan Lilya , Calderini Marco , Carlet Claude , Coulter Robert , Villa Irene
Published: October 2020

In this work we give several generalizations of the isotopic shift construction, introduced recently by Budaghyan et al. (IEEE Trans Inform Theory 66:5299–5309, 2020), when the initial function is a Gold function. In particular, we derive a general construction of APN functions which covers several unclassified APN functions for $$n=8$$

n
=
8

and produces fifteen new APN functions for $$n=9$$

n
=
9

.
Differentially low uniform permutations from known 4-uniform functions
Authors: Calderini Marco
Published: October 2020

Functions with low differential uniformity can be used in a block cipher as S-boxes since they have good resistance to differential attacks. In this paper we consider piecewise constructions for permutations with low differential uniformity. In particular, we give two constructions of differentially 6-uniform functions, modifying the Gold function and the Bracken–Leander function on a subfield.
The Anelastic Ericksen Problem: Universal Deformations and Universal Eigenstrains in Incompressible Nonlinear Anelasticity
Authors: Goodbrake Christian , Yavari Arash , Goriely Alain
Published: October 2020

Ericksen’s problem consists of determining all equilibrium deformations that can be sustained solely by the application of boundary tractions for an arbitrary incompressible isotropic hyperelastic material whose stress-free configuration is geometrically flat. We generalize this by first, using a geometric formulation of this problem to show that all the known universal solutions are symmetric with respect to Lie subgroups of the special Euclidean group. Second, we extend this problem to its anelastic version, where the stress-free configuration of the body is a Riemannian manifold. Physically, this situation corresponds to the case where nontrivial finite eigenstrains are present. We characterize explicitly the universal eigenstrains that share the symmetries present in the classical problem, and show that in the presence of eigenstrains, the six known classical families of universal solutions merge into three distinct anelastic families, distinguished by their particular symmetry group. Some generic solutions of these families correspond to well-known cases of anelastic eigenstrains. Additionally, we show that some of these families possess a branch of anomalous solutions, and demonstrate the unique features of these solutions and the equilibrium stress they generate.
Exports and inputs of organic carbon on agricultural soils in Germany
Authors: Jacobs Anna , Poeplau Christopher , Weiser Christian , Fahrion-Nitschke Andrea , Don Axel
Published: October 2020

The quantity and quality of organic carbon (Corg) input drive soil Corg stocks and thus fertility and climate mitigation potential of soils. To estimate fluxes of Corg as net primary production (NPP), exports, and inputs on German arable and grassland soils, we used field management data surveyed within the Agricultural Soil Inventory (n = 27.404 cases of sites multiplied by years). Further, we refined the concept of yield-based Corg allocation coefficients and delivered a new regionalized method applicable for agricultural soils in Central Europe. Mean total NPP calculated for arable and grassland soils was 6.9 ± 2.3 and 5.9 ± 2.9 Mg Corg ha−1 yr−1, respectively, of which approximately half was exported. On average, total Corg input calculated did not differ between arable (3.7 ± 1.8 Mg ha−1 yr−1) and grassland soils (3.7 ± 1.3 Mg ha−1 yr−1) but Corg sources were different: Grasslands received 1.4 times more Corg from root material than arable soils and we suggest that this difference in quality rather than quantity drives differences in soil Corg stocks between land use systems. On arable soils, side products were exported in 43% of the site * years. Cover crops were cultivated in 11% of site * years and contributed on average 3% of the mean annual total NPP. Across arable crops, total NPP drove Corg input (R2 = 0.47) stronger than organic fertilization (R2 = 0.11). Thus, maximizing plant growth enhances Corg input to soil. Our results are reliable estimates of management related Corg fluxes on agricultural soils in Germany.
Control of fouling in the aquaculture of Fucus vesiculosus and Fucus serratus by regular desiccation
Authors: Meichssner Rafael , Stegmann Nadja , Cosin Anna-Sarah , Sachs Dagobert , Bressan Matthias , Marx Henriette , Krost Peter , Schulz Rüdiger
Published: October 2020

Fouling is a major problem in seaweed aquaculture and one of the main obstacles during the domestication process for new culture species. During first attempts to cultivate Fucus vesiculosus and Fucus serratus in the Kiel fjord (Western Baltic Sea), fouling by the epizoans Electra pilosa, Mytilus sp., and Amphibalanus improvisus rendered the production of marketable biomass impossible. This study tested (1) if regular desiccation by air exposure is effective in decreasing the abundance and size of foulers and (2) if and how regular desiccation affects the growth performance of the cultivated Fucus thalli. For this purpose, thalli of F. vesiculosus and F. serratus were cultivated freely floating in baskets directly deployed in the fjord and desiccated to defined percentages of the wet weight (ww) by air exposure. The treatments comprised controls and desiccations of different intensities (from 90 to 40% of ww) and at different frequencies (1× week−1, 3× week−1). Growth rates of both Fucus species were not or only slightly reduced by the desiccation treatments. The final harvested biomass of F. vesiculosus under frequent mild desiccations (3× week−1 to 80% of ww) was even higher than the biomass of undesiccated controls. The size of the epizoans E. pilosa and A. improvisus was significantly reduced by the desiccation treatments and the abundance of all epizoan species was drastically reduced by the desiccation regimes. Frequent mild desiccations (F. vesiculosus: 3× week−1 to 80% of ww, F. serratus: 3× week−1 to 90% of ww) proved to be most effective and decreased the epizoan ww share of the total harvest from 13.0 ± 4.8% in the control to 1.8 ± 0.2% for F. vesiculosus and from 19.1 ± 2.7 to 1.0 ± 0.1% for F. serratus. Thus, desiccation seems to be an effective measure for the production of clean Fucus biomass in culture which is necessary for further valorization. A technical solution for the implementation of this procedure in large-scale cultures remains to be developed.
Who will go the extra mile? Selecting organizational citizens with a personality-based structured job interview
Authors: Heimann Anna Luca , Ingold Pia V. , Debus Maike E. , Kleinmann Martin
Published: October 2020

Employees’ organizational citizenship behaviors (OCB) are important drivers of organizational effectiveness. Yet, there exist no established tools for selecting employees with a propensity to engage in OCB. Given that personality traits describe typical behavioral tendencies and are established OCB predictors, we propose that personality assessment is a useful approach for selecting employees who are likely to exhibit OCB. To test this proposition, we developed a structured job interview measuring the Big Five traits and then compared this interview to a personality self-report measure to determine which method of personality assessment works best for selecting organizational citizens. Employees (N = 223) from various occupations participated in the structured job interview and completed the personality self-report in a simulated selection setting. We then obtained supervisor ratings of employees’ OCB. Results supported the assumption that structured job interviews can be specifically designed to assess the Big Five personality traits and, most importantly, to predict OCB. Interview ratings of specific personality traits differentially predicted different types of OCB (i.e., OCB-compliance, OCB-helping, and OCB-initiative) and explained incremental variance in OCB over and above personality self-reports and verbal cognitive ability. Taken together, these findings expand our knowledge about dispositional predictors of OCBs, personality assessment in selection, and the design of job interviews.
Composition of Strawberry Floral Volatiles and their Effects on Behavior of Strawberry Blossom Weevil, Anthonomus rubi
Authors: Mozūraitis Raimondas , Hall David , Trandem Nina , Ralle Baiba , Tunström Kalle , Sigsgaard Lene , Baroffio Catherine , Fountain Michelle , Cross Jerry , Wibe Atle , Borg-Karlson Anna-Karin
Published: October 2020

The strawberry blossom weevil (SBW), Anthonomus rubi, is a major pest in strawberry fields throughout Europe. Traps baited with aggregation pheromone are used for pest monitoring. However, a more effective lure is needed. For a number of pests, it has been shown that the attractiveness of a pheromone can be enhanced by host plant volatiles. The goal of this study was to explore floral volatile blends of different strawberry species (Fragaria x ananassa and Fragaria vesca) to identify compounds that might be used to improve the attractiveness of existing lures for SBW. Floral emissions of F. x a. varieties Sonata, Beltran, Korona, and of F. vesca, were collected by both solid-phase microextraction (SPME) and dynamic headspace sampling on Tenax. Analysis by gas chromatography/mass spectrometry showed the floral volatiles of F. x ananassa. and F. vesca were dominated by aromatic compounds and terpenoids, with 4-methoxybenzaldehyde (p-anisaldehyde) and α-muurolene the major compounds produced by the two species, respectively. Multi-dimensional scaling analyses separated the blends of the two species and explained differences between F. vesca genotypes and, to some degree, variation between F. x ananassa varieties In two-choice behavioral tests, SBW preferred odors of flowering strawberry plants to those of non-flowering plants, but weevils did not discriminate between odors from F. x ananassa and F. vesca flowering plants. Adding blends of six synthetic flower volatiles to non-flowering plants of both species increased the preference of SBW for these over the plants alone. When added individually to non-flowering plants, none of the components increased the preference of SBW, indicating a synergistic effect. However, SBW responded to 1,4-dimethoxybenzene, a major component of volatiles from F. viridis, previously found to synergize the attractiveness of the SBW aggregation pheromone in field studies.
How Do Memories of Having Been Parented Relate to the Parenting-Experience of Fathers in Treatment for Intimate Partner Violence? A Phenomenological Analysis
Authors: Mohaupt Henning , Duckert Fanny , Askeland Ingunn Rangul
Published: October 2020

Few studies have examined how men who use intimate partner violence (IPV) experience being a parent. This study describes how Norwegian men in treatment for IPV reflect upon the impact of their childhood experiences on their fathering. We interviewed 11 men in treatment for IPV regarding their fathering experience, and their memories of having been parented. We performed a descriptive phenomenological analysis of the data. We identified two superordinate themes that described the participants’ fathering experience: being a benign versus being a detrimental force in the child’s life and having the intention of not repeating and the actual repetition of harmful parenting. The participants described being conflicted regarding being potentially damaging for their child’s development. They generally described a lack of stable positive relationships, both early in life and in the present. Partner-violent men’s meaning making of their fathering seems to be influenced by their early-life experiences with their parents in several problematic ways. Fathers who use IPV may both accept and reject that they have been harmed by the parenting they received as children. Similarly, they may both acknowledge and discard that their use of violence harms their children. We suggest that therapy should explore these themes and their consequences for the father - child relationship.
Analysing experiences and issues in self-built shelters in Bangladesh using transdisciplinary approach
Authors: Klansek Tonja , Coley David A. , Paszkiewicz Natalia , Albadra Dima , Rota Federico , Ball Richard J.
Published: October 2020

There are currently 70.8 million forcibly displaced people, globally. Bangladesh hosts the largest refugee camp in the world. Much effort has gone into the research, design and delivery of mass-produced shelters. Yet most refugees live in self-built shelters using simple shelter materials. This paper aims to demonstrate the benefits of using a transdisciplinary approach for holistic data collection in such shelters. A total of 1594 households were surveyed in refugee camps in Bangladesh using diverse methods—e.g. surveys, semi-structured interviews, physical measurements. It was only because of the use of various methods that the reasons behind identified issues were discovered or quantified. For example, household surveys uncovered the issue of poor ventilation, but only the semi-structured interviews exposed the reasons behind it, while physical measurements assessed the implications of this—annual particulate exposure 13 times the recommended limit. Furthermore, several methods pointed to issues with materials, but only the focus groups discussions exposed the need for gender-sensitive technical training tailored for women on the correct use of the materials. This study demonstrates that a diverse team (humanitarian staff, building physicists, and anthropologists) using several approaches to data-gathering and working in a transdisciplinary manner has much to offer the sector, and by including quantitative physical measurements allows costed improvement plans to be developed, targets to be set and general, rather than case specific, knowledge to be generated. The findings of this study have resulted in new shelter interventions by the aid sector that were rolled out in over 70,000 shelters.
A Metric for Evaluating a Transformation of Subscription-Based Journals into Open-Access Journals
Authors: Mielke Corinna , Kuballa Stefanie , Schulze Mareike , Haux Reinhold
Published: October 2020

Open Access is an upcoming paradigm to communicate scientific knowledge. The Trans-O-MIM Project works on strategies, models, and evaluation metrics for the goal-oriented, stepwise, sustainable, and fair transformation of established subscription-based scientific journals into open-access-based journals. This research intends to present an evaluation metric and the associated identified appropriate parameters for such transformations. To develop the evaluation metric, it has been implemented in the context of a business management method for planning, steering and controlling action and corporate strategies. The central element was a 3-step procedure for developing the metric. In stage 1 necessary preconditions for a transformation were considered. Stage 2 is the actual elaboration of the evaluation metric by means of a scenario analysis and stage 3 comprises the exemplary testing at the journal Methods of Information in Medicine. The three methodological steps have primarily resulted in 5 scenarios with 9 different final states from the scenario analysis. Thus, the metric is now composed of these 5 scenarios, which can be used to evaluate the success or failure of a transformation. A list of 65 suitable parameters to measure changes in scenario were compiled. So, it is possible to evaluate the transformation and to find the current final state. Parameters like submissions, publications, and time as well as the scenario states could be applied to the transformation process of the Methods of Information in Medicine journal. The proposed evaluation metric can be used to evaluate the transformation processes of subscription-based journals into open-access-based journals.
Generalized Swift–Hohenberg and phase-field-crystal equations based on a second-gradient phase-field theory
Authors: Espath Luis , Calo Victor M. , Fried Eliot
Published: October 2020

The principle of virtual power is used derive a microforce balance for a second-gradient phase-field theory. In conjunction with constitutive relations consistent with a free-energy imbalance, this balance yields a broad generalization of the Swift–Hohenberg equation. When the phase field is identified with the volume fraction of a conserved constituent, a suitably augmented version of the free-energy imbalance yields constitutive relations which, in conjunction with the microforce balance and the constituent content balance, delivers a broad generalization of the phase-field-crystal equation. Thermodynamically consistent boundary conditions for situations in which the interface between the system and its environment is structureless and cannot support constituent transport are also developed, as are energy decay relations that ensue naturally from the thermodynamic structure of the theory.
Expensive multi-objective optimization of electromagnetic mixing in a liquid metal
Authors: Prinz Sebastian , Thomann Jana , Eichfelder Gabriele , Boeck Thomas , Schumacher Jörg
Published: October 2020

This paper presents a novel trust-region method for the optimization of multiple expensive functions. We apply this method to a biobjective optimization problem in fluid mechanics, the optimal mixing of particles in a flow in a closed container. The three-dimensional time-dependent flows are driven by Lorentz forces that are generated by an oscillating permanent magnet located underneath the rectangular vessel. The rectangular magnet provides a spatially non-uniform magnetic field that is known analytically. The magnet oscillation creates a steady mean flow (steady streaming) similar to those observed from oscillating rigid bodies. In the optimization problem, randomly distributed mass-less particles are advected by the flow to achieve a homogeneous distribution (objective function 1) while keeping the work done to move the permanent magnet minimal (objective function 2). A single evaluation of these two objective functions may take more than two hours. For that reason, to save computational time, the proposed method uses interpolation models on trust-regions for finding descent directions. We show that, even for our significantly simplified model problem, the mixing patterns vary significantly with the control parameters, which justifies the use of improved optimization techniques and their further development.
Inclusive education in Italy: Historical steps, positive developments, and challenges
Authors: Ianes Dario , Demo Heidrun , Dell’Anna Silvia
Published: October 2020

The Italian school system has a long tradition of inclusive education, starting in the 1970s with the first experiences of integrating students with disabilities into regular schools. Since then, legislation has developed to guarantee students with disabilities and other special educational needs the right to individualization and personalization. This article presents the main developments in Italian inclusive education, documenting both positive outcomes and ongoing challenges, especially those which could be of interest for international readers. The article is structured around three relevant themes: the persistent influence of an individual-medical model of disability on school practices; support opportunities and additional resources for inclusion; and monitoring and evaluation mechanisms and their role in the improvement of the quality of inclusion.
Randomized controlled trial of a group intervention combining self-hypnosis and self-care: secondary results on self-esteem, emotional distress and regulation, and mindfulness in post-treatment cancer patients
Authors: Grégoire C. , Faymonville M.-E. , Vanhaudenhuyse A. , Jerusalem G. , Willems S. , Bragard I.
Published: October 2020

Purpose

Cancer patients often report low self-esteem and high emotional distress. Two factors seem particularly linked to these symptoms: emotion regulation strategies and mindfulness. The interest of hypnosis and self-care to relieve these symptoms is not well documented. Our randomized controlled trial aimed at assessing the effect of a group intervention combining self-hypnosis and self-care on self-esteem, emotional distress, emotion regulation, and mindfulness abilities of post-treatment cancer patients, as well as investigating the links between these variables.

Methods

One hundred and four patients who had suffered from cancer were randomized into the intervention group (N = 52) and the wait-list control group (N = 52). They had to answer questionnaires before (T1) and after the intervention (T2). Nine men were excluded from the analyses, leading to a final sample of 95 women with cancer. Group-by-time changes were assessed with MANOVA, and associations with self-esteem and emotional distress were investigated with hierarchical linear regression models.

Results

Participants in the intervention group (mean age = 51.65; SD = 12.54) reported better self-esteem, lower emotional distress, a decreased use of maladaptive emotion regulation strategies, and more mindfulness abilities after the intervention, compared to the WLCG. This increase in mindfulness explained 33% of the improvement of self-esteem and 41.6% of the decrease of emotional distress in the intervention group. Self-esteem and emotional distress also predicted each other.

Conclusion

Our study showed the efficacy of our hypnosis-based intervention to improve all the investigated variables. Mindfulness predicted the improvement of self-esteem and emotional distress. The primary impact of our intervention on mindfulness abilities seems to explain, at least in part, its efficacy.

Registration: ClinicalTrials.gov (NCT03144154). Retrospectively registered on the 1st of May, 2017.
Links between psychological disengagement from school and different forms of self-esteem in the crucial period of early and mid-adolescence
Authors: Martinot Delphine , Beaton Ann , Tougas Francine , Redersdorff Sandrine , Rinfret Natalie
Published: October 2020

The purpose of this study was to test the links between psychological disengagement from academics and self-esteem during two different periods of adolescence. Previous research provided mixed findings on the links between both psychological disengagement mechanisms (i.e., discounting and devaluing) and self-esteem. To clarify this relationship, global self-esteem as well as self-esteem in school attainment and social domains were assessed among 142 early-adolescents (aged 11 to 12) and 172 mid-adolescents (aged 13 to 15). According to the Psychological Disengagement Model, it was predicted that experience of personal deprivation due to perceived relative academic underachievement would be associated with discounting of academic grades. In turn, a link between discounting and devaluing from school was expected. Both psychological disengagement mechanisms were predicted to harm global self-esteem and self-esteem in the school attainment domains. However, discounting and devaluing were expected to increase self-esteem in the social domains among mid- rather than early-adolescents. Path analyses support in part prediction. Both psychological disengagement mechanisms played a different role on global and domain-specific self-esteem. Among early-adolescents, discounting reduced global self-esteem and self-esteem in school attainment domains. Findings pointed to the self-protective role of discounting on self-esteem in social domains among mid-adolescents as well as the non-protective function of devaluing on global self-esteem, school attainment and social domains of self-esteem. This study contributes by clarifying the links between psychological disengagement from academics and self-esteem at two distinct periods in adolescence and the specific domains of self-esteem.
The Psychobiology of Hunger – A Scientific Perspective
Authors: Beaulieu Kristine , Blundell John
Published: October 2020

From a scientific perspective, hunger can be regarded as an identifiable conscious sensation which can be distinguished from other conscious states (e.g., pain, fear). The hunger state can be measured and is a marker of the existence of underlying biological processes. Measured hunger is functional and is normally associated with the act of eating. However, the conscious state of hunger, although driven physiologically, is not exclusively determined by biology; there is an environmental influence that can modulate its intensity and periodicity, and cultural factors that shape the appropriateness of the expression of hunger. Within a psychobiological framework, hunger can be considered as the expression of a ‘need state’ which mediates between biological requirements and environmental (nutritional) satisfaction. Our empirical studies show that hunger is clearly associated with biological signals (e.g., resting metabolic rate and some gastrointestinal peptides) and is central to the relationship between energy expenditure and energy intake.
Multiscale determinants of Pacific chorus frog occurrence in a developed landscape
Authors: Green Jemma , Govindarajulu Purnima , Higgs Eric
Published: October 2020

Pacific chorus frog (Pseudacris regilla) populations have persisted despite urban and rural development throughout the species’ range; yet it is possible thatP. regilla, like other anurans with which it historically co-occurred, will become extirpated from cities and suburbs if urbanization intensifies as predicted. An improved understanding of the conditions that enable this species to persist in developed landscapes is needed to identify and conserve suitable habitats. We investigated species-habitat relationships forP. regillain a mixed urban-rural landscape in southwestern British Columbia, Canada, to identify potential criteria for habitat suitability. We conducted repeat auditory surveys of chorusing males at 52 potential breeding wetlands and modeled occupancy at 26 of these sites using local and landscape variables representing competing hypotheses and spatial scales of influence. The models that best explainedP. regillaoccupancy included a combination of terrestrial habitat and connectivity factors and the presence of non-native predators. We found that the proportion of impervious cover within 250 m of a wetland had the strongest negative impact on occupancy. Our findings suggest that availability of terrestrial habitat adjacent to breeding sites is the primary driver of species presence in the developed landscape. Conservation efforts should seek to limit impervious cover to less than 20% within a 250-m buffer around breeding wetlands. Further, restored and created wetlands in urban and rural areas may be more likely to supportP. regillaif they are designed with a seasonal hydroperiod that excludes non-native aquatic predators and are placed in an area of high pond density.
Characterization of plasma lipidomics in adolescent subjects with increased risk for type 1 diabetes in the DiPiS cohort
Authors: Andersson Svärd Agnes , Kaur Simranjeet , Trôst Kajetan , Suvitaival Tommi , Lernmark Åke , Maziarz Marlena , Pociot Flemming , Overgaard Anne Julie ,   The DiPiS Study Group
Published: October 2020

Introduction

Type 1 diabetes (T1D) is caused by the destruction of pancreatic islet beta cells resulting in total loss of insulin production. Recent studies have suggested that the destruction may be interrelated to plasma lipids.

Objectives

Specific lipids have previously been shown to be decreased in children who develop T1D before four years of age. Disturbances of plasma lipids prior to clinical diagnosis of diabetes, if true, may provide a novel way to improve prediction, and monitor disease progression.

Methods

A lipidomic approach was utilized to analyze plasma from 67 healthy adolescent subjects (10–15 years of age) with or without islet autoantibodies but all with increased genetic risk for T1D. The study subjects were enrolled at birth in the Diabetes Prediction in Skåne (DiPiS) study and after 10–15 years of follow-up we performed the present cross-sectional analysis. HLA-DRB345, -DRB1, -DQA1, -DQB1, -DPA1 and -DPB1 genotypes were determined using next generation sequencing. Lipidomic profiles were determined using ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometry. Lipidomics data were analyzed according to genotype.

Results

Variation in levels of several specific phospholipid species were related to level of autoimmunity but not development of T1D. Five glycosylated ceramides were increased in insulin autoantibody (IAA) positive adolescent subjects compared to adolescent subjects without this autoantibody. Additionally, HLA genotypes seemed to influence levels of long chain triacylglycerol (TG).

Conclusion

Lipidomic profiling of adolescent subjects in high risk of T1D may improve sub-phenotyping in this high risk population.
Intervention by international organizations in regime complexes
Authors: Margulis Matias E.
Published: October 2020

This article identifies the existence of a previously unknown but important type of self-directed political behavior by International Organizations (IOs) that I termintervention. Intervention occurs when an IO secretariat acts with the intention of altering an anticipated decision at a partially-overlapping IO in a regime complex. Intervention is a distinct type of behavior by IOs that differs from either bureaucratic competition among IOs for mandates, resources and policy influence, or cooperation to achieve joint regulatory goals and enhance performance. I probe the plausibility of intervention through an analysis of three illustrative case studies in the regime complex for food security showing self-directed political actions by the secretariats of the Food and Agriculture Organization (FAO), World Food Programme (WFP) and Office of the High Commissioner for Human Rights (OHCHR) directed at altering decision-making by states at the World Trade Organization (WTO). I identify three distinct intervention strategies – mobilizing states, public shaming and invoking alternative legal frameworks – in which IOs utilize their material, ideational and symbolic capabilities to influence decision-making not within their own institutions, but at other, overlapping organizations in a regime complex over which they have no direct control.
Transformation of β-SiC from Charcoal, Coal, and Petroleum Coke to α-SiC at Higher Temperatures
Authors: Jayakumari Sethulakshmy , Tangstad Merete
Published: October 2020

SiC is one of the main intermediate compounds formed during the industrial production of silicon (Si). In the Si process, SiC is produced when carbon added to the raw materials reacts with the silicon monoxide gas (SiO(g)) formed in the furnace. Carbon materials used are either biomass-based (charcoal and wood chips) or based on fossil sources (coal, coke, petroleum coke). The most common forms of SiC prevailing at atmospheric pressure are the polytypes of α-SiC and β-SiC. β-SiC is formed at low temperatures and transforms to α-SiC at higher temperatures (> 2000 °C). In this study, β-SiC with elemental Si of varying amounts, formed from industrial carbon materials (charcoal, coal, and petroleum coke), were utilized to study the transformation of β-SiC to α-SiC. A graphite tube furnace efficient for high-temperature experiments was utilized for the heat treatment of β-SiC particles at temperatures ranging from 2100 °C to 2450 °C. The transformation to α-SiC was greatly influenced by the original carbon source. Charcoal-converted β-SiC particles easily transformed to α-SiC at 2100 °C, compared with β-SiC produced from coal and petroleum coke. Moreover, the amount of elemental Si in SiC particles enhanced the transformation to α-SiC at 2100 °C.
Intra-coronary Imaging for the Evaluation of Plaque Modifications Induced by Drug Therapies for Secondary Prevention
Authors: Kilic Ismail Dogu , Fabris Enrico , Kedhi Elvin , Ghilencea Liviu-Nicolae , Caiazzo Gianluca , Sherif Sara Abou , Di Mario Carlo
Published: October 2020

Purpose of Review

Patients diagnosed with coronary artery disease are at a high risk of subsequent cardiovascular events; therefore, secondary prevention in the form of therapeutic lifestyle changes, and drug therapies is vital. This article aims to review potential application of intra-coronary imaging for the evaluation of plaque modifications, induced by medications for secondary prevention for CAD.

Recent Findings

Intra-coronary imaging provides detailed information on the atherosclerotic plaque which is the primary pathological substrate for the recurrent ischemic cardiovascular events. These modalities can detect features associated with high risk and allow serial in vivo imaging of lesions. Therefore, intravascular imaging tools have been used in landmark studies and played a role in improving our understanding of the disease processes.

Changes in size and plaque composition over time can be evaluated by these tools and may help understanding the impact of a treatment. Moreover, surrogate imaging end points can be used when testing new drugs for secondary prevention.
Deformations of Calabi-Yau manifolds in Fano toric varieties
Authors: Bini Gilberto , Iacono Donatella
Published: October 2020

In this article, we investigate deformations of a Calabi-Yau manifold Z in a toric variety F, possibly not smooth. In particular, we prove that the forgetful morphism from the Hilbert functor HZF of infinitesimal deformations of Z in F to the functor of infinitesimal deformations of Z is smooth. This implies the smoothness of HZF at the corresponding point in the Hilbert scheme. Moreover, we give some examples and include some computations on the Hodge numbers of Calabi-Yau manifolds in Fano toric varieties.
Bi-directional online transfer learning: a framework
Authors: McKay Helen , Griffiths Nathan , Taylor Phillip , Damoulas Theo , Xu Zhou
Published: October 2020

Transfer learning uses knowledge learnt in source domains to aid predictions in a target domain. When source and target domains are online, they are susceptible to concept drift, which may alter the mapping of knowledge between them. Drifts in online environments can make additional information available in each domain, necessitating continuing knowledge transfer both from source to target and vice versa. To address this, we introduce the Bi-directional Online Transfer Learning (BOTL) framework, which uses knowledge learnt in each online domain to aid predictions in others. We introduce two variants of BOTL that incorporate model culling to minimise negative transfer in frameworks with high volumes of model transfer. We consider the theoretical loss of BOTL, which indicates that BOTL achieves a loss no worse than the underlying concept drift detection algorithm. We evaluate BOTL using two existing concept drift detection algorithms: RePro and ADWIN. Additionally, we present a concept drift detection algorithm, Adaptive Windowing with Proactive drift detection (AWPro), which reduces the computation and communication demands of BOTL. Empirical results are presented using two data stream generators: the drifting hyperplane emulator and the smart home heating simulator, and real-world data predicting Time To Collision (TTC) from vehicle telemetry. The evaluation shows BOTL and its variants outperform the concept drift detection strategies and the existing state-of-the-art online transfer learning technique.
mxkernel: A Novel System Software Stack for Data Processing on Modern Hardware
Authors: Mühlig Jan , Müller Michael , Spinczyk Olaf , Teubner Jens
Published: October 2020

Emerging hardware platforms are characterized by large degrees of parallelism, complex memory hierarchies, and increasing hardware heterogeneity. Their theoretical peak data processing performance can only be unleashed if the different pieces of systems software collaborate much more closely and if their traditional dependencies and interfaces are redesigned.

We have developed the key concepts and a prototype implementation of a novel system software stack named mxkernel. For MxKernel, efficient large scale data processing capabilities are a primary design goal. To achieve this, heterogeneity and parallelism become first-class citizens and deep memory hierarchies are considered from the very beginning. Instead of a classical “thread” model, mxkernel provides a simpler control flow abstraction: mxtasks model closed units of work, for which mxkernel will guarantee the required execution semantics, such exclusive access to a specific object in memory. They can be a very elegant abstraction also for heterogeneity and resource sharing. Furthermore, mxtasks are annotated with metadata, such as code variants (to support heterogeneity), memory access behavior (to improve cache efficiency and support memory hierarchies), or dependencies between mxtasks (to improve scheduling and avoid synchronization cost). With precisely the required metadata available, mxkernel can provide a lightweight, yet highly efficient form of resource management, even across applications, operating system, and database.

Based on the mxkernel prototype we present preliminary results from this ambitious undertaking. We argue that threads are an ill-suited control flow abstraction for our modern computer architectures and that a task-based execution model is to be favored.