bluuebunny/crossref_metadata_2025 huggingface dataset:
Protein Kinase CK2 Expression Predicts Relapse Survival in ERα Dependent Breast Cancer, and Modulates ERα Expression in Vitro
Authors: Williams Marlon , Nguyen Thu , Carriere Patrick , Tilghman Syreeta , Williams Christopher
Published: December 2015

The heterotetrameric protein kinase CK2 has been associated with oncogenic transformation, and our previous studies have shown that it may affect estrogenic signaling. Here, we investigate the role of the protein kinase CK2 in regulating ERα (estrogen receptor α) signaling in breast cancer. We determined the correlation of CK2α expression with relapse free breast cancer patient survival utilizing Kaplan Meier Plotter (kmplot.com/analysis/) to mine breast cancer microarrays repositories. Patients were stratified according to ERα status, histological grade, and hormonal therapy. Luciferase reporter assays and flow cytometry were implemented to determine the impact of CK2 inhibition on ERE-mediated gene expression and expression of ERα protein. CK2α expression is associated with shorter relapse free survival among ERα (+) patients with grade 1 or 2 tumors, as well as among those patients receiving hormonal therapy. Biochemical inhibition of CK2 activity results in increased ER-transactivation as well as increased expression among ERα (+) and ERα (−) breast cancer cell lines. These findings suggest that CK2 may contribute to estrogen-independent cell proliferation and breast tumor progression, and may potentially serve as a biomarker and pharmacological target in breast cancer.
Minority College Women’s Views on Condom Negotiation
Authors: McLaurin-Jones TyWanda , Lashley Maudry-Beverly , Marshall Vanessa
Published: December 2015

This study utilized quantitative and qualitative methods to (1) investigate the relationship between frequency of condom use and negotiation strategies and (2) evaluate experiences with condom negotiations among sexually active, heterosexual, African American college women. One hundred female students from a Historically Black Colleges and Universities (HBCU) completed a questionnaire that included the Condom Influence Strategies Scale (CIS) and participated in a focus group. An ANOVA was conducted to compare differences between never, inconsistent, and consistent condom users. Consistent condom users scored higher than never users on the “withholding sex” subscale of the CIS (4.88 vs. 3.55; p < 0.001) as well as endorsed items more strongly on the “direct request” subscale of the CIS (4.63 vs. 3.82, p < 0.05) than never users. A thematic analysis of open discussions identified overarching themes. Similarly, refusing sex and/or having direct communications with partner emerged as primary strategies. Threats to negotiation included deciding the “right timing” of discussion and having a previous history of sexual intercourse without a condom with their partner. Other key concepts that contribute to condom negotiation are the views that condoms are a male’s responsibility and stigma of women who carry condoms.
Local Health Departments’ Activities to Address Health Disparities and Inequities: Are We Moving in the Right Direction?
Authors: Shah Gulzar , Sheahan John
Published: December 2015

Context: Health disparities are among the critical public health challenges. Objectives: To analyze the extent to which local health departments (LHDs) perform activities for addressing health disparities, changes in proportion of LHDs’ performing those activities since 2005, and factors associated with variation in such engagement. Methods: We used the 2013 National Profile of LHDs Survey to perform Logistic Regression of activities LHDs performed to address health disparities. Results: About 20 percent of LHDs did not perform any activity to address health disparities. Significant decreases occurred since 2005 in the proportion of LHDs that performed health disparity reduction/elimination activities for four activities. LHD characteristics significantly associated (p≤0.05) with the increased likelihood of performing activities to address health disparities were: recent completion of community health assessment, community health improvement plan and agency wide strategic plan. Other significant positive impacts on such activities included per capita expenditures, local governance, having one or more local boards of health, larger population size and metropolitan status of the LHD jurisdiction. Conclusions: Reduced infrastructural capacity of LHDs has resulted in fewer LHDs addressing health disparities in their jurisdictions. LHD characteristics associated with higher performance of activities for health disparity reduction identified by this research have important policy implications.
Computer Optimization of Biodegradable Nanoparticles Fabricated by Dispersion Polymerization
Authors: Akala Emmanuel , Adesina Simeon , Ogunwuyi Oluwaseun
Published: December 2015

Quality by design (QbD) in the pharmaceutical industry involves designing and developing drug formulations and manufacturing processes which ensure predefined drug product specifications. QbD helps to understand how process and formulation variables affect product characteristics and subsequent optimization of these variables vis-à-vis final specifications. Statistical design of experiments (DoE) identifies important parameters in a pharmaceutical dosage form design followed by optimizing the parameters with respect to certain specifications. DoE establishes in mathematical form the relationships between critical process parameters together with critical material attributes and critical quality attributes. We focused on the fabrication of biodegradable nanoparticles by dispersion polymerization. Aided by a statistical software, d-optimal mixture design was used to vary the components (crosslinker, initiator, stabilizer, and macromonomers) to obtain twenty nanoparticle formulations (PLLA-based nanoparticles) and thirty formulations (poly-ɛ-caprolactone-based nanoparticles). Scheffe polynomial models were generated to predict particle size (nm), zeta potential, and yield (%) as functions of the composition of the formulations. Simultaneous optimizations were carried out on the response variables. Solutions were returned from simultaneous optimization of the response variables for component combinations to (1) minimize nanoparticle size; (2) maximize the surface negative zeta potential; and (3) maximize percent yield to make the nanoparticle fabrication an economic proposition.
Epidemiologic, Racial and Healthographic Mapping of Delaware Pediatric Cancer: 2004–2014
Authors: Holmes Laurens , Vandenberg Jonathan , McClarin Lavisha , Dabney Kirk
Published: December 2015

Childhood cancer remains the leading cause of disease-related death among children 0 to 14 years and incidence varies by race, ethnicity, sex, geographic locale, and age at onset. However, data are unavailable in some regions, indicative of a need for such information for cancer awareness, education and prevention program. We utilized retrospective epidemiologic design to assess and characterize pediatric tumors in the Nemours Electronic Medical Records, between 2004 and 2014. Tumor frequency and children population size were used to determine the period prevalence as cumulative incidence (CI) proportion, as well as chi-square and Poisson Regression. The CI for overall childhood cancer in Delaware was 234 per 100,000 children, and varied by race, black (273 per 100,000), white (189 per 100,000). Similarly, sex variability was observed in CI, boys (237 per 100,000) and girls (230 per 100,000). The most commonly diagnosed malignancies were acute lymphoblastic leukemia (ALL), Central Nervous System (CNS)/brain and renal cancer. The geographic locales with relatively higher cancer CI in the state of DE were zip codes 19804 and 19960, but this does not imply cancer clustering. Differences in overall childhood cancer distribution occurred by race, sex, geography, and age. These findings are indicative of the need for cancer-specific health education, awareness and prevention programs in reducing the observed disparities in Delaware.
Persistent HIV Viremia: Description of a Cohort of HIV Infected Individuals with ART Failure in Puerto Rico
Authors: Maldonado-Martínez Gerónimo , Hunter-Mellado Robert , Fernández-Santos Diana , Ríos-Olivares Eddy
Published: December 2015

The introduction of antiretroviral therapy (ART) has allowed human immunodeficiency virus (HIV) suppression in patients. We present data of a cohort of Puerto Rican patients with HIV who were under treatment with a steady regime of ART across a time horizon of eleven years. The time periods were categorized into four year stratums: 2000 to 2002; 2003 to 2005; 2006 to 2008 and 2009 to 2011. Socio-demographic profile, HIV risk factors, co-morbid conditions were included as study variables. One year mortality was defined. The p value was set at ≤0.05. The cohort consisted of 882 patients with 661 subjects presenting with persistent HIV viral load after a self-reported 12 month history of ART use. In this sub-cohort a higher viral load was seen across time (p < 0.05). Illicit drug use, IV drug use, alcohol use, loss of work were associated to having higher viral load means (p < 0.05). HIV viral load mean was lower as BMI increased (p < 0.001). It is imperative to readdress antiretroviral adherence protocols and further study ART tolerance and compliance.
Color It Real: A Program to Increase Condom Use and Reduce Substance Abuse and Perceived Stress
Authors: Zellner Tiffany , Trotter Jennie , Lenoir Shelia , Walston Kelvin , Men-Na’a L’dia , Henry-Akintobi Tabia , Miller Assia
Published: December 2015

Few interventions have targeted perceived stress as a co-occurring construct central to substance use and subsequent HIV/AIDS risk reduction among African American urban young adults. The Color It Real Program was a seven session, weekly administered age-specific and culturally-tailored intervention designed to provide substance abuse and HIV education and reduce perceived stress among African Americans ages 18 to 24 in Atlanta, GA. Effectiveness was assessed through a quasi-experimental study design that consisted of intervention (n = 122) and comparison (n = 70) groups completing a pre- and post-intervention survey. A series of Analysis of Variance (ANOVA) tests were used to assess pre- to post-intervention changes between study groups. For intervention participants, perceived stress levels were significantly reduced by the end of the intervention (t(70) = 2.38, p = 0.020), condom use at last sexual encounter significantly increased (F = 4.43, p = 0.0360), intervention participants were significantly less likely to drink five or more alcoholic drinks in one sitting (F = 5.10, p = 0.0245), and to use clean needles when injecting the drug (F = 36.99, p = 0.0001). This study is among the first of its kind to incorporate stress management as an integral approach to HIV/SA prevention. The program has implications for the design of other community-based, holistic approaches to addressing substance use and risky behaviors for young adults.
Increasing Cervical Cancer Awareness and Screening in Jamaica: Effectiveness of a Theory-Based Educational Intervention
Authors: Coronado Interis Evelyn , Anakwenze Chidinma , Aung Maug , Jolly Pauline
Published: December 2015

Despite declines in cervical cancer mortality in developed countries, cervical cancer incidence and mortality rates remain high in Jamaica due to low levels of screening. Effective interventions are needed to decrease barriers to preventive behaviors and increase adoption of behaviors and services to improve prospects of survival. We enrolled 225 women attending health facilities in an intervention consisting of a pre-test, educational presentation and post-test. The questionnaires assessed attitudes, knowledge, risk factors, and symptoms of cervical cancer among women. Changes in knowledge and intention to screen were assessed using paired t-tests and tests for correlated proportions. Participants were followed approximately six months post-intervention to determine cervical cancer screening rates. We found statistically significant increases from pre-test to post-test in the percentage of questions correctly answered and in participants’ intention to screen for cervical cancer. The greatest improvements were observed in responses to questions on knowledge, symptoms and prevention, with some items increasing up to 62% from pre-test to post-test. Of the 123 women reached for follow-up, 50 (40.7%) screened for cervical cancer. This theory-based education intervention significantly increased knowledge of and intention to screen for cervical cancer, and may be replicated in similar settings to promote awareness and increase screening rates.
Impact of ASUMA Intervention on HIV Risk Behaviors among Puerto Rican Adolescents
Authors: Fernandez-Santos Diana , Miranda-Diaz Christine , Figueroa-Cosme Wanda , Ramon Raul , Mayor Angel , Rios-Olivares Eddy , Hunter-Mellado Robert
Published: December 2015

The purpose of this manuscript is to assess and compare HIV risk behaviors among early adolescents after a three-year pilot study. A total of 135 public and private junior high schools students completed the intervention protocol. A self-administered questionnaire was given at baseline and at the end of the third year (fourth measure). Descriptive and inferential analyses were performed using SPSS 20.0. About 60% of the students were 14 years old at the fourth measure. The proportion of students that did not report at least one HIV risk behavior at baseline and those that reported any risk behavior at the fourth measure was lower in the intervention group (45.0%) than in the control group (54.5%). The proportion of students that reported at least one HIV risk behavior at baseline and those that did not report any HIV risk behavior at the fourth measure was higher in the intervention group than in the control group (33.3% vs. 8.3%). The proportion of students engaging in HIV risk behaviors was higher in the control group than in the intervention group at the fourth measure, suggesting that A Supportive Model for HIV Risk Reduction in Early Adolescence (ASUMA) intervention might be a promising initiative to reduce adolescents’ engagement in HIV risk behaviors.
Rapid Assessment of Environmental Health Impacts for Policy Support: The Example of Road Transport in New Zealand
Authors: Briggs David , Mason Kylie , Borman Barry
Published: December 2015

An integrated environmental health impact assessment of road transport in New Zealand was carried out, using a rapid assessment. The disease and injury burden was assessed from traffic-related accidents, air pollution, noise and physical (in)activity, and impacts attributed back to modal source. In total, road transport was found to be responsible for 650 deaths in 2012 (2.1% of annual mortality): 308 from traffic accidents, 283 as a result of air pollution, and 59 from noise. Together with morbidity, these represent a total burden of disease of 26,610 disability-adjusted life years (DALYs). An estimated 40 deaths and 1874 DALYs were avoided through active transport. Cars are responsible for about 52% of attributable deaths, but heavy goods vehicles (6% of vehicle kilometres travelled, vkt) accounted for 21% of deaths. Motorcycles (1 per cent of vkt) are implicated in nearly 8% of deaths. Overall, impacts of traffic-related air pollution and noise are low compared to other developed countries, but road accident rates are high. Results highlight the need for policies targeted at road accidents, and especially at heavy goods vehicles and motorcycles, along with more general action to reduce the reliance on private road transport. The study also provides a framework for national indicator development.
Food Safety, a Global Challenge
Authors: Uyttendaele Mieke , Franz Eelco , Schlüter Oliver
Published: December 2015

To provide more food and make use of precious water and nutrient resources, communities increasingly value sustainable food production. [...]
Synthesis of Minerals with Iron Oxide and Hydroxide Contents as a Sorption Medium to Remove Arsenic from Water for Human Consumption
Authors: Garrido-Hoyos Sofia , Romero-Velazquez Lourdes
Published: December 2015

Arsenic has been classified as a toxic and carcinogenic chemical element. It therefore presents a serious environmental problem in different regions of the country and the world. In the present work, two adsorbent media were developed and evaluated to remove arsenic from water in the Pájaro Verde mine shaft, Huautla, Tlaquiltenango, Morelos. The media were synthesized and characterized, obtaining a surface area of 43.04 m2·g−1 for the goethite and 2.44 m2·g−1 for silica sand coated with Fe(III). To conduct the sorption kinetics and isotherms, a 23 factorial design was performed for each medium in order to obtain the optimal conditions for the factors of arsenic concentration, pH and mass of the adsorbent. The best results were obtained for goethite, with a removal efficiency of 98.61% (C0 of As(V) 0.360 mg·L−1), and an effluent concentration of 0.005 mg·L−1, a value that complies with the modified Official Mexican Standard NOM-127-SSA1-1994 [1] and WHO guidelines (2004) [2]. The kinetic equation that best fit the experimental data was the pseudo-second-order, resulting in the highest values for the constants for synthetic goethite, with a rate constant sorption of 4.019·g·mg−1·min−1. With respect to the sorption isotherms, both media were fitted to the Langmuir-II linear model with a sorption capacity (qm) of 0.4822 mg·g−1 for goethite and 0.2494 mg·g−1 for silica sand coated with Fe(III).
Effects of Co-Worker and Supervisor Support on Job Stress and Presenteeism in an Aging Workforce: A Structural Equation Modelling Approach
Authors: Yang Tianan , Shen Yu-Ming , Zhu Mingjing , Liu Yuanling , Deng Jianwei , Chen Qian , See Lai-Chu
Published: December 2015

We examined the effects of co-worker and supervisor support on job stress and presenteeism in an aging workforce. Structural equation modelling was used to evaluate data from the 2010 wave of the Health and Retirement Survey in the United States (n = 1649). The level of presenteeism was low and the level of job stress was moderate among aging US workers. SEM revealed that co-worker support and supervisor support were strongly correlated (β = 0.67; p < 0.001). Job stress had a significant direct positive effect on presenteeism (β = 0.30; p < 0.001). Co-worker support had a significant direct negative effect on job stress (β = −0.10; p < 0.001) and presenteeism (β = −0.11; p < 0.001). Supervisor support had a significant direct negative effect on job stress (β = −0.40; p < 0.001) but not presenteeism. The findings suggest that presenteeism is reduced by increased respect and concern for employee stress at the workplace, by necessary support at work from colleagues and employers, and by the presence of comfortable interpersonal relationships among colleagues and between employers and employees.
Research Advances on Pathways of Nickel-Induced Apoptosis
Authors: Guo Hongrui , Chen Lian , Cui Hengmin , Peng Xi , Fang Jing , Zuo Zhicai , Deng Junliang , Wang Xun , Wu Bangyuan
Published: December 2015

High concentrations of nickel (Ni) are harmful to humans and animals. Ni targets a number of organs and produces multiple toxic effects. Apoptosis is important in Ni-induced toxicity of the kidneys, liver, nerves, and immune system. Apoptotic pathways mediated by reactive oxygen species (ROS), mitochondria, endoplasmic reticulum (ER), Fas, and c-Myc participate in Ni-induced cell apoptosis. However, the exact mechanism of apoptosis caused by Ni is still unclear. Understanding the mechanism of Ni-induced apoptosis may help in designing measures to prevent Ni toxicity.
Fibroblast Growth Factor 21 Suppresses Adipogenesis in Pig Intramuscular Fat Cells
Authors: Wang Yongliang , Liu Xinyi , Hou Liming , Wu Wangjun , Zhao Shuhong , Xiong Yuanzhu
Published: December 2015

Fibroblast growth factor 21 (FGF21) plays an important role in the treatment of disease associated with muscle insulin resistance which is characterized by various factors, such as intramuscular triglyceride (IMT) content. Studies have also shown that FGF21 inhibits triglyceride synthesis in vivo. However, the precise mechanism whereby FGF21 regulates triglyceride metabolism in intramuscular fat (IMF), which may influence the muscle insulin sensitivity, is not clearly understood. In order to understand the role of FGF21 in IMF deposition, we performed FGF21 overexpression in IMF cells by stable transfection. Our results showed that FGF21 inhibited the key adipogenesis gene mRNA expression of peroxisome proliferator-activated receptor gamma (PPARG), CCAAT/enhancer-binding protein (CEBP) family by reducing lysine-specific demethylase 1 (LSD1) expression which led to significant decline in lipid accumulation, and the result was confirmed by Western blot. Moreover, triggered by FGF21, parts of the adipokines—fatty acid-binding protein 4 (FABP4), glucose transporter 4 (GLUT4), adiponectin (ADIPOQ), and perilipin (PLIN1)—were also down-regulated. Furthermore, FGF21 gene expression was suppressed by transcription factor CEBP beta (CEBPB) which contributed strongly to triglyceride synthesis. Taken together, our study is the first to experimentally demonstrate FGF21 emerging as an efficient blockade of adipogenesis in IMF, thus also providing a new understanding of the mechanism whereby FGF21 improves insulin sensitivity.
Colliding Epidemics and the Rise of Cryptococcosis
Authors: Chang Christina , Chen Sharon
Published: December 2015

Discovered more than 100 years ago as a human pathogen, the Cryptococcus neoformans–Cryptococcus gattii (C. neoformans–C. gattii) complex has seen a large global resurgence in its association with clinical disease in the last 30 years. First isolated in fermenting peach juice, and identified as a human pathogen in 1894 in a patient with bone lesions, this environmental pathogen has now found niches in soil, trees, birds, and domestic pets. Cryptococcosis is well recognized as an opportunistic infection and was first noted to be associated with reticuloendothelial cancers in the 1950s. Since then, advances in transplant immunology, medical science and surgical techniques have led to increasing numbers of solid organ transplantations (SOT) and hematological stem cell transplantations being performed, and the use of biological immunotherapeutics in increasingly high-risk and older individuals, have contributed to the further rise in cryptococcosis. Globally, however, the major driver for revivification of cryptococcosis is undoubtedly the HIV epidemic, particularly in Sub-Saharan Africa where access to care and antiretroviral therapy remains limited and advanced immunodeficiency, poverty and malnutrition remains the norm. As a zoonotic disease, environmental outbreaks of both human and animal cryptococcosis have been reported, possibly driven by climate change. This is best exemplified by the resurgence of C. gattii infection in Vancouver Island, Canada, and the Pacific Northwest of the United States since 1999. Here we describe how the colliding epidemics of HIV, transplantation and immunologics, climate change and migration have contributed to the rise of cryptococcosis.
Biomass Pyrolysis Solids as Reducing Agents: Comparison with Commercial Reducing Agents
Authors: Adrados Aitziber , De Marco Isabel , López-Urionabarrenechea Alexander , Solar Jon , Caballero Blanca , Gastelu Naia
Published: December 2015

Biomass is one of the most suitable options to be used as renewable energy source due to its extensive availability and its contribution to reduce greenhouse gas emissions. Pyrolysis of lignocellulosic biomass under appropriate conditions (slow heating rate and high temperatures) can produce a quality solid product, which could be applicable to several metallurgical processes as reducing agent (biocoke or bioreducer). Two woody biomass samples (olives and eucalyptus) were pyrolyzed to produce biocoke. These biocokes were characterized by means of proximate and ultimate analysis, real density, specific surface area, and porosity and were compared with three commercial reducing agents. Finally, reactivity tests were performed both with the biocokes and with the commercial reducing agents. Bioreducers have lower ash and sulfur contents than commercial reducers, higher surface area and porosity, and consequently, much higher reactivity. Bioreducers are not appropriate to be used as top burden in blast furnaces, but they can be used as fuel and reducing agent either tuyére injected at the lower part of the blast furnace or in non-ferrous metallurgical processes where no mechanical strength is needed as, for example, in rotary kilns.
Determination of Insulator-to-Semiconductor Transition in Sol-Gel Oxide Semiconductors Using Derivative Spectroscopy
Authors: Lee Woobin , Choi Seungbeom , Kim Kyung , Kang Jingu , Park Sung , Kim Yong-Hoon
Published: December 2015

We report a derivative spectroscopic method for determining insulator-to-semiconductor transition during sol-gel metal-oxide semiconductor formation. When an as-spun sol-gel precursor film is photochemically activated and changes to semiconducting state, the light absorption characteristics of the metal-oxide film is considerable changed particularly in the ultraviolet region. As a result, a peak is generated in the first-order derivatives of light absorption (A′) vs. wavelength (λ) plots, and by tracing the peak center shift and peak intensity, transition from insulating-to-semiconducting state of the film can be monitored. The peak generation and peak center shift are described based on photon-energy-dependent absorption coefficient of metal-oxide films. We discuss detailed analysis method for metal-oxide semiconductor films and its application in thin-film transistor fabrication. We believe this derivative spectroscopy based determination can be beneficial for a non-destructive and a rapid monitoring of the insulator-to-semiconductor transition in sol-gel oxide semiconductor formation.
Extended Functional Groups (EFG): An Efficient Set for Chemical Characterization and Structure-Activity Relationship Studies of Chemical Compounds
Authors: Salmina Elena , Haider Norbert , Tetko Igor
Published: December 2015

The article describes a classification system termed “extended functional groups” (EFG), which are an extension of a set previously used by the CheckMol software, that covers in addition heterocyclic compound classes and periodic table groups. The functional groups are defined as SMARTS patterns and are available as part of the ToxAlerts tool (http://ochem.eu/alerts) of the On-line CHEmical database and Modeling (OCHEM) environment platform. The article describes the motivation and the main ideas behind this extension and demonstrates that EFG can be efficiently used to develop and interpret structure-activity relationship models.
Preparative Isolation of Two Prenylated Biflavonoids from the Roots and Rhizomes of Sinopodophyllum emodi by Sephadex LH-20 Column and High-Speed Counter-Current Chromatography
Authors: Sun Yan-Jun , Pei Li-Xin , Wang Kai-Bo , Sun Yin-Shi , Wang Jun-Min , Zhang Yan-Li , Gao Mei-Ling , Ji Bao-Yu
Published: December 2015

Two prenylated biflavonoids, podoverines B–C, were isolated from the dried roots and rhizomes of Sinopodophyllum emodi using a Sephadex LH-20 column (SLHC) and high-speed counter-current chromatography (HSCCC). The 95% ethanol extract was partitioned with ethyl acetate in water. Target compounds from the ethyl acetate fraction were further enriched and purified by the combined application of SLHC and HSCCC. n-Hexane–ethyl acetate–methanol–water (3.5:5:3.5:5, v/v) was chosen as the two phase solvent system. The flow rate of mobile phase was optimized at 2.0 mL·min−1. Finally, under optimized conditions, 13.8 mg of podoverine B and 16.2 mg of podoverine C were obtained from 200 mg of the enriched sample. The purities of podoverines B and C were 98.62% and 99.05%, respectively, as determined by HPLC. For the first time, podoverins B and C were found in the genus Sinopodophyllum. Their structures were determined by spectroscopic methods (HR-ESI-MS, 1H-NMR, 13C-NMR, HSQC, HMBC). Their absolute configurations were elucidated by comparison of their experimental and calculated ECD spectra. The cytotoxic activities were evaluated against MCF-7 and HepG2 cell lines. The separation procedures proved to be practical and economical, especially for trace prenylated biflavonoids from traditional Chinese medicine.
Synthesis and Crystal Structures of Benzimidazole-2-thione Derivatives by Alkylation Reactions
Authors: El Ashry El , El Kilany Yeldez , Nahas Nariman , Barakat Assem , Al-Qurashi Nadia , Ghabbour Hazem , Fun Hoong-Kun
Published: December 2015

Alkylated, benzylated and bromoalkylated benzimidazole-thione that intramolecularly heterocyclized to 3,4-dihydro-2H-[1,3]thiazino[3,2-a]benzimidazole were synthesized. The chemical structure of the synthesized product was characterized by Infra Red, 1H-NMR, 13C-NMR, and Mass spectroscopy. Furthermore, the molecular structures of 8 and 9 were confirmed by X-ray single crystallography in different space groups, Pbca and P21/c, respectively.
Social Pharmacy and Clinical Pharmacy—Joining Forces
Authors: Almarsdottir Anna , Granas Anne
Published: December 2015

This commentary seeks to define the areas of social pharmacy and clinical pharmacy to uncover what they have in common and what still sets them apart. Common threats and challenges of the two areas are reviewed in order to understand the forces in play. Forces that still keep clinical and social pharmacy apart are university structures, research traditions, and the management of pharmacy services. There are key (but shrinking) differences between clinical and social pharmacy which entail the levels of study within pharmaceutical sciences, the location in which the research is carried out, the choice of research designs and methods, and the theoretical foundations. Common strengths and opportunities are important to know in order to join forces. Finding common ground can be developed in two areas: participating together in multi-disciplinary research, and uniting in a dialogue with internal and external key players in putting forth what is needed for the profession of pharmacy. At the end the question is posed, “What’s in a name?” and we argue that it is important to emphasize what unifies the families of clinical pharmacy and social pharmacy for the benefit of both fields, pharmacy in general, and society at large.
Double Blind Peer-Review in Religions
Authors: Rittman Martyn , Kaufman Peter
Published: December 2015

Pre-publication peer-review forms the basis for how scholarly journals assess whether an article is suitable for publication. [...]
Sea-Ice Wintertime Lead Frequencies and Regional Characteristics in the Arctic, 2003–2015
Authors: Willmes Sascha , Heinemann Günther
Published: December 2015

The presence of sea-ice leads represents a key feature of the Arctic sea ice cover. Leads promote the flux of sensible and latent heat from the ocean to the cold winter atmosphere and are thereby crucial for air-sea-ice-ocean interactions. We here apply a binary segmentation procedure to identify leads from MODIS thermal infrared imagery on a daily time scale. The method separates identified leads into two uncertainty categories, with the high uncertainty being attributed to artifacts that arise from warm signatures of unrecognized clouds. Based on the obtained lead detections, we compute quasi-daily pan-Arctic lead maps for the months of January to April, 2003–2015. Our results highlight the marginal ice zone in the Fram Strait and Barents Sea as the primary region for lead activity. The spatial distribution of the average pan-Arctic lead frequencies reveals, moreover, distinct patterns of predominant fracture zones in the Beaufort Sea and along the shelf-breaks, mainly in the Siberian sector of the Arctic Ocean as well as the well-known polynya and fast-ice locations. Additionally, a substantial inter-annual variability of lead occurrences in the Arctic is indicated.
Investigation on the Weighted RANSAC Approaches for Building Roof Plane Segmentation from LiDAR Point Clouds
Authors: Xu Bo , Jiang Wanshou , Shan Jie , Zhang Jing , Li Lelin
Published: December 2015

RANdom SAmple Consensus (RANSAC) is a widely adopted method for LiDAR point cloud segmentation because of its robustness to noise and outliers. However, RANSAC has a tendency to generate false segments consisting of points from several nearly coplanar surfaces. To address this problem, we formulate the weighted RANSAC approach for the purpose of point cloud segmentation. In our proposed solution, the hard threshold voting function which considers both the point-plane distance and the normal vector consistency is transformed into a soft threshold voting function based on two weight functions. To improve weighted RANSAC’s ability to distinguish planes, we designed the weight functions according to the difference in the error distribution between the proper and improper plane hypotheses, based on which an outlier suppression ratio was also defined. Using the ratio, a thorough comparison was conducted between these different weight functions to determine the best performing function. The selected weight function was then compared to the existing weighted RANSAC methods, the original RANSAC, and a representative region growing (RG) method. Experiments with two airborne LiDAR datasets of varying densities show that the various weighted methods can improve the segmentation quality differently, but the dedicated designed weight functions can significantly improve the segmentation accuracy and the topology correctness. Moreover, its robustness is much better when compared to the RG method.
The Potential Use of Multi-Band SAR Data for Soil Moisture Retrieval over Bare Agricultural Areas: Hebei, China
Authors: Zhang Xiang , Chen Baozhang , Fan Hongdong , Huang Jilei , Zhao Hui
Published: December 2015

The potential use of TerraSAR-X and Radarsat-2 data for soil moisture retrieval over bare agricultural areas was investigated using both empirical and semi-empirical approaches. For the empirical approach, the Support Vector Regression (SVR) model was used with two cases: (1) using only one C-band or X-band image; and (2) using a pair of C-band and X-band images jointly. For the semi-empirical approach, the modified Dubois model based on C-band and X-band SAR data was developed to estimate soil moisture content. The experiments were implemented over two bare agricultural areas, and in-situ measurements were carried out to assess the methods. The results showed that the TerraSAR-X and Radarsat-2 are suitable remote sensing tools for the estimation of surface soil moisture, with an accuracy of about 3 vol % (root mean square error, RMSE) over bare agricultural areas. Compared with the results obtained by Radarsat-2 data, TerraSAR-X data gives a slight improvement in estimating soil moisture. The accuracy of the soil moisture estimation was improved further when the two bands SAR data were used (RMSE of about 2.2 vol %) instead of only one. Moreover, the modified Dubois model showed comparable accuracy to the empirical model independent of the surface roughness.
Optical Thickness and Effective Radius Retrievals of Low Stratus and Fog from MTSAT Daytime Data as a Prerequisite for Yellow Sea Fog Detection
Authors: Yi Li , Thies Boris , Zhang Suping , Shi Xiaomeng , Bendix Jörg
Published: December 2015

Operational nowcasting techniques for sea fog over the Yellow Sea rely on data from weather satellites because ground-based observations are hardly available. While there are several algorithms for detecting low stratus (LST) that are applicable to geostationary weather satellite data, sea fog retrieval is more complicated. These schemes mostly need ancillary data such as Cloud Optical Thickness (COT) and Droplet Effective Radius (DER). To retrieve the necessary parameters for sea fog detection over the Yellow Sea, the Comprehensive Analysis Program for Cloud Optical Measurement (CAPCOM) scheme developed by Kawamoto et al. (2001) was adapted to the Japanese Multifunctional Transport Satellites (MTSAT) system-Japanese Advanced Meteorological Imager (JAMI). COT and DER values were then retrieved for 64 cases over the Yellow Sea (= 85,000 LST pixels) and compared with the COT and DER products from the MYD06/MOD06, CAPCOM-MODIS (Moderate Resolution Imaging Spectroradiometer) and CloudSat (cloud radar). Results showed that the COT and DER values retrieved from JAMI were satisfactory. The MTSAT-2 JAMI data delivered better COT values than the MTSAT-1R JAMI data, due to the re-calibration of MTSAT-2 JAMI’s visible (VIS) band in 2011. Similarly, improvements were seen in DER retrieval, even though the VIS re-calibration primarily affects COT retrieval. By comparing the difference in stratus thickness calculated by MTSAT-1R and MTSAT-2, the COT and DER retrieved from MTSAT-2 JAMI can be used in ground fog retrieval schemes. These values exhibit less bias, especially in cases involving high cloud top and thin cloud thickness. Both the COT and DER retrievals from MTSAT-2 JAMI offer potential as reliable parameters for Yellow Sea fog detection.
Spatially-Explicit Testing of a General Aboveground Carbon Density Estimation Model in a Western Amazonian Forest Using Airborne LiDAR
Authors: Molina Patricio , Asner Gregory , Farjas Abadía Mercedes , Ojeda Manrique Juan , Sánchez Diez Luis , Valencia Renato
Published: December 2015

Mapping aboveground carbon density in tropical forests can support CO2 emission monitoring and provide benefits for national resource management. Although LiDAR technology has been shown to be useful for assessing carbon density patterns, the accuracy and generality of calibrations of LiDAR-based aboveground carbon density (ACD) predictions with those obtained from field inventory techniques should be intensified in order to advance tropical forest carbon mapping. Here we present results from the application of a general ACD estimation model applied with small-footprint LiDAR data and field-based estimates of a 50-ha forest plot in Ecuador’s Yasuní National Park. Subplots used for calibration and validation of the general LiDAR equation were selected based on analysis of topographic position and spatial distribution of aboveground carbon stocks. The results showed that stratification of plot locations based on topography can improve the calibration and application of ACD estimation using airborne LiDAR (R2 = 0.94, RMSE = 5.81 Mg·C·ha−1, BIAS = 0.59). These results strongly suggest that a general LiDAR-based approach can be used for mapping aboveground carbon stocks in western lowland Amazonian forests.
Robust Foot Clearance Estimation Based on the Integration of Foot-Mounted IMU Acceleration Data
Authors: Benoussaad Mourad , Sijobert Benoît , Mombaur Katja , Azevedo Coste Christine
Published: December 2015

This paper introduces a method for the robust estimation of foot clearance during walking, using a single inertial measurement unit (IMU) placed on the subject’s foot. The proposed solution is based on double integration and drift cancellation of foot acceleration signals. The method is insensitive to misalignment of IMU axes with respect to foot axes. Details are provided regarding calibration and signal processing procedures. Experimental validation was performed on 10 healthy subjects under three walking conditions: normal, fast and with obstacles. Foot clearance estimation results were compared to measurements from an optical motion capture system. The mean error between them is significantly less than 15 % under the various walking conditions.
Novel H+-Ion Sensor Based on a Gated Lateral BJT Pair
Authors: Yuan Heng , Zhang Jixing , Cao Chuangui , Zhang Gangyuan , Zhang Shaoda
Published: December 2015

An H+-ion sensor based on a gated lateral bipolar junction transistor (BJT) pair that can operate without the classical reference electrode is proposed. The device is a special type of ion-sensitive field-effect transistor (ISFET). Classical ISFETs have the advantage of miniaturization, but they are difficult to fabricate by a single fabrication process because of the bulky and brittle reference electrode materials. Moreover, the reference electrodes need to be separated from the sensor device in some cases. The proposed device is composed of two gated lateral BJT components, one of which had a silicide layer while the other was without the layer. The two components were operated under the metal-oxide semiconductor field-effect transistor (MOSFET)-BJT hybrid mode, which can be controlled by emitter voltage and base current. Buffer solutions with different pH values were used as the sensing targets to verify the characteristics of the proposed device. Owing to their different sensitivities, both components could simultaneously detect the H+-ion concentration and function as a reference to each other. Per the experimental results, the sensitivity of the proposed device was found to be approximately 0.175 μA/pH. This experiment demonstrates enormous potential to lower the cost of the ISFET-based sensor technology.
The Effects of Interdependence and Cooperative Behaviors on Buyer’s Satisfaction in the Semiconductor Component Supply Chain
Authors: Pai Fan-Yun , Yeh Tsu-Ming
Published: December 2015

The semiconductor industry is characterized by extreme competition in price and product features. Firms need to acquire or exchange resources with their supplier or buyer partners to stay at the leading edge of technology. Cooperation between buyers and suppliers is important and power is the mechanism that can explain the cooperative behaviors. This study aims to investigate how the power structure between the buyer and supplier influences the extent of suppliers’ cooperative behaviors, and the effects of these on buyer satisfaction with the buyer-supplier relationship. Opinions from firms in semiconductor manufacturing supply chain were used to investigate the proposed model. It is found that mutual interdependence between a supplier and its buyer can enhance cooperative behaviors and power asymmetry hurt firms’ investment in cooperative behaviors. Suggestions are then provided to semiconductor supply chain members based on the findings of this work.
Development of Manufacturing Sustainability Assessment Using Systems Thinking
Authors: Moldavska Anastasiia , Welo Torgeir
Published: December 2015

The existing body of knowledge in sustainability assessment of manufacturing indicates that although extensive research is going on, significant shortcomings remain unsolved. In this paper, the specific needs of a new sustainability assessment system are discussed. Systems thinking is suggested as an alternative to the reductionist approach which is commonly applied to sustainability assessment. Although previous research has recognized the potential of systems thinking applied to sustainability assessment, few practical examples have been demonstrated. Therefore, this article focuses on a practical application of systems thinking to the development of a sustainability assessment system of a manufacturing organization. A framework for development is proposed employing systems thinking. It is suggested that systems thinking reveals several aspects usually not addressed by the reductionist approaches. It is demonstrated that a combination of tools like analysis of multiple viewpoints, conceptagon, seven samurai, and model-based systems engineering can enhance a development of a suitable assessment systems.
Research on Consumers’ Use Willingness and Opinions of Electric Vehicle Sharing: An Empirical Study in Shanghai
Authors: Wang Ning , Yan Runlin
Published: December 2015

An empirical study in Shanghai was performed to explore consumers’ use willingness and opinions on electric vehicle sharing (EVS) to help operators effectively operate and expand the new business model. Through the multinomial logistic regression developed for different groups, the results show that the factors of the main trip mode in daily use, monthly transportation expenditure, driving range of electric vehicles, gender, age, marital status and occupation have significant influences on consumers’ use willingness. In short, the population characteristics of people choosing to use EVS are male, aged between 18 and 30 and usually taking the subway and bus as the daily transportation modes. Otherwise, the factors of the acceptable highest price of EVS, occupation and personal monthly income have significant impacts on the use willingness of people who keep a neutral stance. These people pay more attention to convenience and the economy of EVS. These results reveal that a reasonable price, accurate positioning of target groups, convenient site layout and usage are required for operators to successfully launch a new transportation mode of EVS.
TRIM19/PML Restricts HIV Infection in a Cell Type-Dependent Manner
Authors: Kahle Tanja , Volkmann Bianca , Eissmann Kristin , Herrmann Alexandra , Schmitt Sven , Wittmann Sabine , Merkel Laura , Reuter Nina , Stamminger Thomas , Gramberg Thomas
Published: December 2015

The promyelocytic leukemia protein (PML) is the main structural component of the nuclear matrix structures termed nuclear domain 10 (ND10) or PML nuclear bodies (PML-NBs). PML and ND10 structures have been shown to mediate an intrinsic immune response against a variety of different viruses. Their role during retroviral replication, however, is still controversially discussed. In this study, we analyzed the role of PML and the ND10 components Daxx and Sp100 during retroviral replication in different cell types. Using cell lines exhibiting a shRNA-mediated knockdown, we found that PML, but not Daxx or Sp100, inhibits HIV and other retroviruses in a cell type-dependent manner. The PML-mediated block to retroviral infection was active in primary human fibroblasts and murine embryonic fibroblasts but absent from T cells and myeloid cell lines. Quantitative PCR analysis of HIV cDNA in infected cells revealed that PML restricts infection at the level of reverse transcription. Our findings shed light on the controversial role of PML during retroviral infection and show that PML contributes to the intrinsic restriction of retroviral infections in a cell type-dependent manner.
The Assessment of Competitiveness: The Case of Three Alpine Winter Sports Destinations
Authors: Hallmann Kirstin , Mueller Sabine , Peters Mike
Published: December 2015

A number of scientific contributions have attempted to measure destination competitiveness with the help of destination performance indicators either categorized as supply-side or demand-side measures. There is a lack of empirical studies that assess performance evaluation of both supply
and demand side. Therefore, based on the theoretical discussion of destination competitiveness models, a selection of demand- and supply-side relevant indicators were developed and operationalized. The article aims at measuring destination competitiveness both perceived by tourists but also
by stakeholders within three winter sports destinations. A logistic regression analysis for the quality standard of the tourism product as the dependent variable was carried out. The quality of accommodation, hotel staff, and information management, but also destination policy and planning
indicators significantly influence the perception of the quality standard of the tourism product. This article concludes with recommendations for destination marketing.
The Needs of Older Patients for Peritoneal Dialysis: Training and Support at Home
Authors: Hurst Helen , Figueiredo Ana E.
Published: December 2015

Chronic kidney disease (CKD) in all its stages has become an important problem for older patients, stage 3 – 5 is expected to happen in 25 to 30% of the population, and a higher prevalence can be found in residential care and nursing homes, affecting the demand for patient education. Although older patients are able and keen to learn, there are specific needs that must be addressed. The focus of this paper is to review the demands to train and maintain older patients on peritoneal dialysis (PD) at home.