bluuebunny/crossref_metadata_2025 huggingface dataset:
ВПЛИВ РІВНЯ ЦИФРОВОЇ ПІДГТОВКИ УЧИТЕЛІВ НА ФОРМУВАННЯ ІНФОРМАЦІЙНО-ЦИФРОВОЇ КОМПЕТЕНТНОСТІ ЗДОБУВАЧІВ ОСВІТИ
Authors: Березіна Ірина Володимирівна
Published: September 2024

У статті висвітлено питання впливу рівня цифрової підготовки учителя на формування інформаційно-цифрової компетентності здобувачів освіти. Показано, що успішне існування особистості в епоху цифровізації може бути забезпечене у разі високого рівня сформованості в неї інформаційно-цифрової компетентності. Представлено генезис досліджень науковцями питання формування інформаційно-цифрової компетентності здобувачів освіти. Зазначено, що інформаційно-цифрова компетентність може бути розглянута як комплекс набутих знань, умінь і навичок або як результат отримання та опрацювання інформації за допомогою цифрових ресурсів. Визначено основні компоненти інформаційно-цифрової компетентності. Наголошено на проблемах, котрі перешкоджають ефективному використанню цифрових технологій в освітньому процесі (відсутність розвиненої методики впровадження цифрових технологій в педагогічний процес; низькі технічні можливості закладів освіти; небажання педагогічних працівників підвищувати рівень власної цифрової компетентності). Здійснено аналіз опитування, проведеного на базі комунального закладу «Харківський ліцей № 12 Харківської міської ради», що дозволив оцінити рівень готовності педагогів до використання цифрових освітніх ресурсів у процесі навчання та рівень знань й умінь педагогічних працівників у сфері цифрових технологій. Представлено заходи з підвищення рівня цифрової підготовки педагогічних працівників, які дали можливість сформувати у педагогічних працівників готовність до застосування цифрових технологій у освітньому процесі. Доведено вплив рівня цифрової підготовки учителя на формування інформаційно-цифрової компетентності здобувачів освіти та наведено приклади використання цифрових застосунків на уроках, що сприяють формуванню у здобувачів освіти зазначеної компетентності.
СУЧАСНІ ТЕНДЕНЦІЇ В ЕКОЛОГІЧНІЙ ОСВІТІ ТА ФОРМУВАННЯ ІНШОМОВНОЇ КОМПЕТЕНТНОСТІ
Authors: Дужик Наталія Степанівна
Published: September 2024

У статті проаналізовано низку актуальних методів викладання англійської мови як іноземної, запропонованих західними та вітчизняними освітянами. Основна увага приділяється підходам, які допомагають викладачам створити комфортне навчальне середовище для українських студентів, які потерпають від війни з Росією. Потреба у міждисциплінарному навчанні обґрунтовується з погляду засвоєння знань. Інтегруючи міждисциплінарний контент, спів-викладачі сприяють поглибленому опануванню матеріалу, удосконалюють дослідницькі та творчі навики студентів, а також розвивають їх здатність досліджувати предмет, що вивчається, з різних точок зору. Показовий приклад спільного навчання демонструє, як представники різних спеціальностей працювали разом над проектом зі збереження морської природи. Разом з ідеєю сталого розвитку, взаємовідносини з природою відіграють ключову роль у створенні комфортного та позитивного навчального середовища. Ставлення суспільства до природи часто визначається міркуваннями економічного зростання та особистими цілями людей. У сучасній освіті переосмислюються питання ставлення до природи як такої, пристосування колективного та індивідуального життя до її потреб, а також проблеми надмірного споживання та виробництва товарів. Низка прикладів ілюструє, як інтегрувати екологічно-доцільну діяльність у вищу освіту. Як частина неформальної освіти, навчання на свіжому повітрі та в Інтернеті аналізується як засіб розвитку творчого та інтроспективного пізнання. Хоча онлайн-навчання не замінює спілкування віч-на-віч, воно дозволяє багаторівнево презентувати навчальний контент за допомогою сучасних технологій, таких як платформи Zoom, Skype, Google meets тощо. Розвиток навиків, які дозволяють студентам здобувати освіту самостійно, є однією з основних ознак сучасної освіти.
ДІЯЛЬНІСНО-ОРІЄНТОВАНЕ НАВЧАННЯ В НІМЕЧЧИНІ ТА УКРАЇНІ: ПОРІВНЯЛЬНИЙ АНАЛІЗ ОРГАНІЗАЦІЙНИХ ТА МЕТОДИЧНИХ АСПЕКТІВ
Authors: Мудра Олена Василівна , Коропатніцька Тетяна Петрівна
Published: September 2024

Стаття присвячена опису можливостей для вивчення іноземних мов, які відкриває діяльнісно-орієнтоване навчання, оскільки воно забезпечує велику рухливість, гнучкість та адаптивність освіти в сучасних умовах. Це є однією з умов формування мобільності учнів у майбутній професійній діяльності. У рамках нашого дослідження вивчається діяльнісно-орієнтоване навчання у школах Німеччини, німецька модель «навчання, орієнтованого на діяльність учнів», та досвід даного дослідження для освіти в Україні. Суперечливий розвиток економічних відносин в Україні виправдовує необхідність осмислення історичного досвіду підготовки учнів до іншомовного спілкування, пошуку пріоритетних напрямів сучасної професійно-педагогічної діяльності, вивчення зарубіжної практики в цій галузі. З огляду на особливості історично сформованих ділових і культурних зв’язків між Україною та Німеччиною й різних форм ділової взаємодії між двома країнами, наочними прикладами якого є високий рівень розвитку україно-німецьких відносин у галузі економіки та німецько-українські проекти з навчання іноземної мови, зокрема LATILL, зростає значення порівняльного аналізу систем навчання Німеччини та України. Аналіз саме німецької моделі навчання обумовлений також тим, що Німеччина є економічно високо розвиненою країною. У ході дослідження було вивчено одну з моделей навчання, застосовуваних у західній практиці, зокрема в Німеччині, – навчання, орієнтоване на діяльність майбутнього фахівця. Це один із методів навчання навичкам прийняття рішень самими учнями та самостійного вирішення проблем, що відіграє важливу роль у розвитку економіки країни. На основі німецької моделі нами розроблено діяльнісно-орієнтовану модель навчання читання іноземною мовою учнів середньої школи. Нами було проведено дослідно-пошукову роботу та проаналізовано її результати. Зокрема, визначено значущість діяльнісно-орієнтованого підходу у навчанні читання іноземною мовою та виявлено вихідний рівень сформованості цих навичок. У ході дослідження з’ясувалося, що для вдосконалення навчання читання іноземною мовою необхідні використання нових форм, методів та технологій, інтеграція природничих, економічних та гуманітарних знань, а також структурування матеріалу. Введення диференційованого підходу до вибору текстів також сприятиме підвищенню ефективності навчання читання іноземною мовою.
ВІЗУАЛІЗАЦІЯ ІНФОРМАЦІЇ В ЛОГОПЕДІЇ: ПОТЕНЦІАЛ ІНТЕРАКТИВНОЇ ІНФОГРАФІКИ ДЛЯ ДІТЕЙ СТАРШОГО ДОШКІЛЬНОГО ВІКУ З ПОРУШЕННЯМИ МОВЛЕННЯ
Authors: Курєнкова Анна Володимирівна , Бойко Світлана Петрівна
Published: September 2024

Стаття присвячена актуальній проблемі використання інтерактивної інфографіки в логопедичній роботі зі старшими дошкільниками, які мають порушення мовлення. Розглянуто особливості монологічного мовлення та його ключову роль у розвитку дитини, наголошуючи на важливості формування зв’язного мовлення для соціальної адаптації та когнітивного розвитку дошкільнят. У роботі ґрунтовно висвітлюється поняття інфографіки, її основні принципи та завдання в контексті корекційно-логопедичної роботи. Акцентовано увагу на перевагах візуалізації інформації, зокрема на її здатності підвищувати ефективність засвоєння матеріалу та стимулювати пізнавальну активність дітей. Стаття містить опис етапів створення інфографіки для дітей 5–7 років з порушеннями мовлення, що включає визначення ідеї, збір та обробку інформації, вибір типу інфографіки, компонування та розробку структури. Надано огляд популярних програм та онлайн-сервісів для розробки інфографіки, аналізуючи їх особливості та можливості застосування в логопедичній практиці. Особлива увага приділяється функціям інтерактивної інфографіки та її впливу на розвиток зв’язного мовлення, пам’яті, уваги та образного мислення дошкільників. Підкреслено, що використання інтерактивної інфографіки сприяє підвищенню мотивації дітей до навчання, робить корекційний процес більш захоплюючим та ефективним. У статті запропоновано поетапний алгоритм роботи з інтерактивною інфографікою в логопедичній практиці, який включає введення елементів схем та умовних позначень, використання візуальних картинок з текстом, застосування прийому від протилежного, навчання комбінування символів та самостійного пошуку образів. Наголошено на важливості адаптації цього підходу до вікових особливостей дітей та специфіки їх мовленнєвих порушень. Робота містить практичні рекомендації щодо впровадження технології інтерактивної інфографіки в освітній процес та підготовки педагогів до її використання.
Valcanale/Kanaltal/Kanalska Dolina 1919-­1950. Crocevia di migrazioni tra le politiche nazionaliste del novecento
Authors: Noto Giada
Published: September 2024

Il presente contributo rappresenta l'esito del progetto di ricerca "Option Digital", condotto dalla Libera Università di Bolzano in collaborazione con la facoltà di Scienze Storiche dell'Università di Innsbruck, che prevedeva la digitalizzazione di documenti relativi alle opzioni di cittadinanza del 1939. L'autrice si è occupata in particolare di un caso di studio relativo all'area della Valcanale (prov. Udine) per cui all'analisi delle fonti digitalizzate è stata affiancata la ricerca presso l'Archivio di Stato di Udine, l'Ufficio Tavolare di Gradisca, l'Archivio della Carinzia, l'Archivio del Tirolo e l'Archivio Provinciale di Bolzano. Il saggio si propone analizzare le diverse migrazioni in Valcanale tra 1919 e 1950. Particolare attenzione sarà posta all'analisi delle Opzioni del 1939, al ruolo dell'Ente Nazionale per le Tre Venezie, al fine di mostrare come il tentativo di colonizzazione procedesse parallelamente sia sul fronte economico che su quello socioculturale. Verrà inoltre evidenziata anche una certa continuità nelle politiche antislave.
Lotta e autorganizzazione. Formazione della classe e mobilitazioni nel comparto della logistica
Authors: Gardini Emilio
Published: September 2024

Il concetto di "lotta di classe" che ha caratterizzato le mobilitazioni del movi-mento operaio fino agli anni settanta del Novecento, non è più ricorrente per de-scrivere i conflitti di lavoro. Questo è avvenuto perché il capitale è riuscito a "rimodellare" la classe operaia attraverso operazioni di "segmentazione di clas-se", introducendo nel sistema produttivo nuovi meccanismi di divisione della for-za-lavoro. Il ricorso all'outsorcing e al subappalto con imprese che assumono a tempo determinato hanno prodotto una frammentazione tra i lavoratori che ha evidenti effetti sull'organizzazione della classe lavoratrice. È possibile, in questo contesto, immaginare nuove possibilità di formazione della classe lavoratrice? Nel paper, attraverso la voce di lavoratori, facchini e driver iscritti al Sindacato di base Intercategioriale SI Cobas che lavorano in aziende e cooperative del set-tore logistica a Napoli e in Campania, si indagano la portata e i significati che assume il conflitto di lavoro oggi.
The Impact of ESG Performance on Corporate Value : Focusing on Managerial Characteristics
Authors:   Korean Association Of Computers And Accounting, Pang Yuan-Long , Jung Woo-Sung
Published: September 2024

[Purpose] It analyzes how ESG management (environment, society, and governance) affects corporate value and analyzes whether these correlations differ according to the CEO’s personal characteristics to further confirm the CEO’s role in ESG activities. Through this, it is intended to present a new perspective on the characteristics of managers and provide an opportunity to increase the importance of ESG activities.
[Methodology] This study collected data from 2,469 companies listed on the Korea Exchange from 2020 to 2022. The data included ESG activity metrics, demographic characteristics of managers, overconfidence, and capabilities. Using multiple regression analysis, the relationship between managerial characteristics and ESG activities was examined.
[Findings] The results indicate that managers with higher levels of overconfidence tend to participate more actively in ESG activities. Additionally, the higher the managerial capability, the more vigorous the ESG activities, which positively influenced corporate value.
[Implications] This study suggests that companies can actively introduce and effectively perform ESG management to improve corporate value. In particular, managers with excellent abilities can actively implement ESG management to improve the corporate image, improve the company’s sustainable management, and maintain the company’s long －term competitive advantage. It can help companies and investors recognize this fact. In the future, more efficient ESG management and investment strategies will be established in consideration of the characteristics of the CEO in the management and investment process.
Research on the Path and Mechanism of Enhancing Student Subjectivity in the Process of University Textbook Selection: A Case Study of S College
Authors: Li Zhi
Published: September 2024

This paper discusses how to promote students' subjectivity in the process of selecting teaching materials in colleges and universities and constructs an effective teaching material selection mechanism. By analyzing the actual situation of S College, this paper reveals the marginalization of students in the decision-making of textbook selection and probes into the significance of enhancing students' subjectivity from both theoretical and practical dimensions. A number of strategies are put forward, including establishing a textbook selection committee, developing an online textbook evaluation system, encouraging individualized textbook selection, and implementing a textbook recycling strategy in order to build an open, active, and student-centered textbook selection mechanism. These strategies not only help to improve teaching quality and students' learning experience but also promote students' all-round development. The purpose of this study is to provide a reference for the reform of higher education and promote the promotion of students' subjectivity and the continuous improvement of education quality.
بناء مقیاس شغب الملاعب لدوري کرة القدم في اقليم کوردستان – العراق
Authors: Asst. Prof. Dr. Diyar Kamal Asaad
Published: September 2024

استخدم الباحث المنهج الوصفي بأسلوب المسحي لملاءمته لطبيعة البحث، وقام ببناء مقايس في كل مجالات متعلقة بشغب الملاعب على حدة من (الاداريين – المدربين – اللاعبين-الحكام-الجمهور – الاعلامين) في محافظات اقليم كوردستان، وشمل مجتمع البحث من (660) شخصا يمثلون المعنيين بشغب الملاعب، واستعان الباحث ب(600) شخصاً منهم كعينة البناء، وتوصل الى بناء مقايس في كل مجال المذكورة لمعالجة البيانات استخدم الحقيبة الاحصائية (SPSS-Vertion 20)
تأثير استخدام أسلوب التدريب الذهني المباشر في تطوير بعض المهارات الاساسية بالكرة الطائرة للطالبات
Authors: Lec. Dr. Jalela Jweer Abdullah
Published: September 2024

ان التدريب الذهني لا يقتصر استخدامه على الاشتراك في المنافسات فقط بل يستخدم في مجال الحركة بشكل عام وفي مراحل اكتساب المهارات الحركية بشكل خاص ويهدف البحث للكشف عن أثر استخدام اسلوب التدريب الذهني المباشر في تطوير بعض المهارات الاساسية بالكرة الطائرة.
وقد وجدت الباحثة بان قلة استخدام اسلوب التدريب الذهني المباشر ضمن المناهج التعليمية المخصصة للكرة الطائرة ظهرت بشكل واضح وبالأخص في السنة الدراسية التي تلي المرحلة التي يتم فيها تعلم الطالبات للمهارات الاساسية بالكرة الطائرة والتي تحتاج إلى زيادة في استخدام اسلوب التدريب الذهني من اجل تطوير المهارات الاساسية بالكرة الطائرة لدى طالبات الكلية.
 واستخدمت الباحثة المنهج التجريبي لملائمة وطبيعة البحث وتكونت عينة البحث من (24) طالبة من طالبات المرحلة الرابعة في كلية التربية البدنية وعلوم الرياضة -جامعة ديالى وتم توزيعهم الى مجموعتين بواقع (12) طالبة لكل مجموعة. واستخدمت الباحثة منهج الكلية بالكرة الطائرة للمرحلة الرابعة مضافا اليه اسلوب التدريب الذهني المباشر للمجموعة التجريبية، اما المجموعة الضابطة فاستخدمت منهج الكلية. ويتكون كل برنامج تعليمي من (12) وحدة تعليمية على مدى (6) اسابيع، بواقع وحدتين تعليميتين في الاسبوع الواحد، ومدة كل وحدة تعليمية (90) دقيقة. واستنتجت الباحثة ان اسلوب التدريب الذهني المباشر فضلا عن المنهاج المقرر لطالبات المرحلة ذو تأثير ايجابي في تطوير بعض المهارات الاساسية بالكرة الطائرة.
بناء وتطبيق مقياس الهشاشة النفسية على طالبات كلية التربية البدنية وعلوم الرياضة في جامعة بابل
Authors: Lec. Dr. Firas Hadi Mohammed Al Jassar
Published: September 2024

يهدف البحث الى بناء مقياس الهشاشة النفسية لدى طالبات كلية التربية. البدنية وعلوم الرياضة في جامعة بابل، والتعرف على واقع الهشاشة النفسية بين طالبات كلية التربية البدنية وعلوم الرياضة في جامعة بابل. واستخدم الباحث المنهج الوصفي بأساليب المسحي والعلاقات الارتباطية لملاءمته لطبيعة ومشكلة البحث واشتمل مجتمع البحث على طالبات المراحل الاربعة في. كلية التربية البدنية وعلوم الرياضة-جامعة بابل للعام الدراسي (2023-2024) والبالغ عددهم (129) طالبة، وتم اختيار عينة البحث بالطريقة. العشوائية وعددهم (117) طالبة لذلك، وتم بناء مقياس خاص به لغرض التعرف على درجة الهشاشة لدى الطالبات وبني المقياس على وفق الخطوات العلمية لأعداد المقاييس. وتكون مقياس الهشاشة النفسية من (36) فقرة مقسمه الى ثلاثة ابعاد (التكبير، الاجترار، العجز) وبلغت فقرات التكبير (12) وفقرات الاجترار(12) وفقرات العجز (12) فقرات وبدائل للإجابة ثلاثية وهي (تنطبق علي دائماً، تنطبق علي احياناً، لا تنطبق علي ابداً) ومفتاح التصحيح لمقياس الهشاشة النفسية (1،2،3).
وخرج البحث باستنتاج تميز طالبات كلية التربية البدنية وعلوم الرياضة في جامعة بابل بانخفاض الهشاشة النفسية بوجه عام، وخرج البحث بعدة توصيات منها ضرورة العمل الجاد على التخلص من الهشاشة النفسية للطلبة لما لها دوراً سلبي كبيراً في تحقيق أهداف العملية التربوية والتعليمية والأهداف المستقبلية للطلبة، العمل على تقليل مستوى الهشاشة النفسية عن طريق البرامج الارشادية، واجراء دراسات تتعلق الهشاشة النفسية لرياضات اخرى وعدد من المتغيرات النفسية للطلبة واللاعبين.
Merger Precursor: Year-long Transients Preceding Mergers of Low-mass Stripped Stars with Compact Objects
Authors: Tsuna Daichi , Wu Samantha C. , Fuller Jim , Dong Yize , Piro Anthony L.
Published: September 2024

Binary mass transfer can occur at high rates due to rapid expansion of the donor’s envelope. In the case where mass transfer is unstable, the binary can rapidly shrink its orbit and lead to a merger. In this work we consider the appearance of the system preceding merger, specifically for the case of a low-mass ( ≈2.5- 3M⊙) helium star with a neutron star (NS) companion. Modeling the mass transfer history as well as the wind launched by super-Eddington accretion onto the NS, we find that such systems can power slowly rising transients with timescales as long as years, and luminosities of ∼1040- 1041 erg s −1 from optical to UV. The final explosion following the merger (or core-collapse of the helium star in some cases) leads to an interaction-powered transient with properties resembling Type Ibn supernovae (SNe), possibly with a bright early peak powered by shock cooling emission for merger-powered explosions. We apply our model to the Type Ibn SN 2023fyq, that displayed a long-term precursor activity from years before the terminal explosion.
Ömer B. Sâlim Bâzmûl’un El-Kırâât Ve Eseruhâ Fi’t-Tefsîr Ve’l-Ahkâm İsimli Eseri Bağlamında Kırâat-Yorum İlişkisi
Authors: Şahin Aynur Hatice
Published: September 2024

Bu makalede, son dönem tefsîr-kırâat geleneğinde kırâat-yorum ilişkisi çerçevesinde kaleme alınan Ömer b. Sâlim Bâzmûl’un el-Kırâât ve eseruhâ fi’t-tefsîr ve’l-ahkâm isimli eseri, kırâat meseleleri ve kırâat farklılıklarının âyetlerin yorumuna etkisi bağlamında ele alınacaktır. Bu çalışma; tarihi ve meseleleri etrafında kırâat ilmi ile kırâatlerin Kur’ân’ı anlamaya etkisi şeklinde iki ana bölümden oluşmaktadır. Bu çerçevede eser, ilk bölümde kırâât, tefsîr, ulûmu’l-Kur’ân, me‘âni’l-Kur’ân ve nahiv kitaplarında muhtelif başlıklar altında yer alan kırâât birikiminin düzenlenip bir araya getirilmesi itibariyle orijinallik arz etmektedir. Ayrıca alana katkı sağlayarak araştırmacıların hedeflenen bilgiye ulaşımını kolaylaştırmaktadır. Eserde birinci cildin neredeyse tamamını kapsayacak şekilde kırâat/kırâat meseleleri ve kırâat tarihine yer verilmektedir. İkinci bölümde ise kırâat-yorum bağlamında kırâatin ayetlerin yorumuna etkisi incelenmektedir. Eserin isminde kırâatlerin ahkâm âyetlerinin tefsirine tesiri yer almış olsa da kitabın muhtevâsında kırâatlerin birçok boyutuyla âyetlere etkisi geniş bir perspektifle ele alınmaktadır. Esere bağlı olarak bu makalede kırâatlerin ahkâm âyetleri de dâhil olmak üzere âyetlere tesirinin incelenmesi çalışmanın ana hedefidir. Ayrıca çalışmada tevcîhte bulunulan kırâatlerin sahih kırâatlere uygunluğunun yansıtılması da araştırmanın amaçları arasında yer almaktadır.
PROTOTYPE PARKING SENSOR ON A SHIP AT THE DOCK USING SENSOR BASED ON ARDUINO UNO R3
Authors: Candli Candli , Pernando Yonky
Published: September 2024

The main issue that needs to be addressed in this research is to enhance the safety and efficiency of the vessel berthing process by reducing the risk of collisions with the dock. With the advancement of technology in the maritime industry, there is still a reliance on various parties such as tugboats, ship crew, and dock authorities to ensure safe vessel berthing. Therefore, it is necessary to design a modern technology-based parking sensor system to provide assistance in the vessel berthing process. By using a parking sensor system based on the Arduino Uno R3 and ultrasonic sensors JSN-SR04T and AJ-SR04M, this research aims to address the risk of collisions with the dock, which can result in serious damage to the vessel, dock, and the surrounding environment. This parking sensor system is designed to reduce this risk by providing early warnings to the users. Furthermore, the research aims to reduce dependence on human factors and minimize human errors. Lastly, the research also aims to improve the efficiency of the vessel berthing process. By designing and implementing this prototype, the research aims to provide a technological solution to address the above-mentioned issues, enhance safety, and optimize the vessel berthing process around Motor Vessel BIN NO.2 EKS. SANYO MARU NO.8.
PREDICTING STUNTING IN TODDLERS IN WEST JAVA USING LINEAR REGRESSION BASED ON POVERTY LEVELS
Authors: Rahmah Nabila Aulia , Khairunisa Nabila , Hidayatulloh Naufal Ammar , Enri Ultach
Published: September 2024

Children's growth is disrupted by stunting, a chronic nutritional condition brought on by a prolonged shortage of nutrient intake. Under-five stunting is a major issue that affects many nations, particularly those with high rates of poverty. The aim of this research is to use the linear regression method based on the proportion of poverty to predict the risk of stunting in children under five in West Java. Growing children are particularly vulnerable to stunting, which can have long-term effects on their development and health. The research site was selected in West Java Province due to the region's high stunting rates and nofigur poverty rate. Precise forecasts are required to surmount the current issues. The research methodology employed is the descriptive quantitative technique. The data, which was projected using percentage values, covered the years 2014–2020. This study uses linear regression as its algorithm. According to the study's findings, there will be an 8.55% chance of toddler stunting in West Java in 2024. It is hoped that the government would be able to lower the risk of stunting by estimating the proportion of risk.
QUALITY ANALYSIS OF THE ELECTRONIC GOVERNMENT PROCUREMENT ORDER SYSTEM USING WEBQUAL AND EUCS METHODS
Authors: Anshar Maulidi Muhammad , Wahyuni Evi Dwi , Wiyono Briansyah Setio
Published: September 2024

Within district of Hulu Sungai Selatan there is a website for the community to offer goods or services, namely SIOPEN, SIOPEN functions as a forum for the HSS community and umkm to offer their goods or services to the local government. The goal of this research is to evaluate SIOPEN's quality using the Webqual approach and users' degree of satisfaction using the EUCS approach. The Webqual approach, which has three dimensions information quality, usability, and interaction service was employed in this research together with the EUCS approach. The EUCS approach has some variables in partikular ease of use, accuracy, format, content, and timeliness. The approach of gathering information data through respondents via sending out online questionnaires to SIOPEN users and determining the sample using the formula from Slovin obtained 88 users then obtained by Webqual Index and Average Satisfaction. The results of research measuring the three dimensions of Webqual show that are in very good interpretation, The information quality dimension obtained 0.8392, the usability dimension obtained 0.8292, then the service interaction dimension obtained 0.8284. The findings  from assessing the level of the satisfied user three variables of EUCS in particular content at a score of 4.27, ease of use at a score of 4.21, and timeliness at a score of 4.28 are at very satisfied level, then the other two variables are accuracy at a score of 4.15 and format at a score of 4.11 at a satisfied level.
MULTILEVEL MODAL VALUE ANALYSIS FOR INTERPRETING CATEGORICAL K-MEDOIDS CLUSTERS DATA
Authors: Fitriyanto Rachmad , Syafiqoh Ummi
Published: September 2024

Consumer segmentation plays a crucial role for business owners in developing their enterprises. K-Medoid is commonly used for segmentation functions due to its low computational complexity. However, K-Medoid has limitations, such as the variability in cluster sizes across different iterations and the challenge of determining the optimal number of clusters. The Davies-Bouldin Index (DBI) is a metric used to evaluate the number of clusters by calculating the ratio between the within-cluster distance and the between-cluster distance. Most segmentation studies typically stop at the formation of clusters without further interpretation, particularly when dealing with categorical data. This study aims to modify the use of K-Medoid and propose a method for interpreting clusters with categorical data. The research began with questionnaire design and the data collecting from 100 respondents, which was normalized in the second stage. Clustering used K-Medoid with variations K values from K=2 to K=10, with each K value tested 10 times. The clustering results were evaluated using the DBI to select the optimal clusters. Data interpretation conducted using modal values, calculated as the ratio of the number of times a specific attribute variable was selected by respondents to the total number of data points in the cluster. Utilization and hierarchical visualization of modal values proposed in this study offer insights into the dominant variables within an attribute and also depict the relationships between attributes based on the ranking of modal values. These advantages facilitate business analysts in labeling clusters for developing consumer-driven business strategies.
BCL-2 targeting combination therapies for neuroblastoma
Authors:   , Vernooij Lindy
Published: September 2024

High-risk neuroblastoma remains one of the most challenging pediatric cancers to treat, with survival rates below 50% and an even poorer prognosis for relapsed patients. Current treatment strategies heavily rely on chemotherapy, often causing severe side effects by targeting both cancerous and healthy cells. Precision medicine, which tailors therapies to the molecular characteristics of each tumor, offers a more personalized therapeutic approach that enables effective targeting of cancer cells while potentially reducing side effects.

This thesis focuses on identifying targeted combination therapies for neuroblastoma patients with high BCL-2 expression. Venetoclax, a selective BCL-2 inhibitor, has shown promise in preclinical studies, but its effectiveness is limited by the development of therapy resistance. In the first part of this work, strategies to prevent or overcome venetoclax resistance were explored. Combining venetoclax with the MDM2 inhibitor idasanutlin was found to resensitize venetoclax-resistant cells, providing support for the clinical development of this combination. Additionally, MCL-1 inhibitors were shown to enhance the effectiveness of venetoclax by preventing therapy-induced resistance.

In the second part of this thesis, we investigated targeted combination therapies for patients with high BCL-2 expression alongside mutations in the RAS-MAPK pathway or ALK. Combining venetoclax with the MEK inhibitor trametinib or the ALK inhibitor lorlatinib resulted in tumor regression across multiple preclinical models, suggesting that these are promising therapeutic strategies for these subgroups of neuroblastoma patients.

In conclusion, the findings presented in this thesis highlight the potential of targeted combination therapies to improve treatment outcomes in high-risk neuroblastoma.
Text VS Discourse: Reformulating the Definition, Integrating Different Perceptions
Authors: Muttaqien Muhammad Zainal , Ulinnuha Roma , Heriyanti Rina
Published: September 2024

There have long been different perceptions on what text and discourse are. Some experts in linguistics view these two objects as the same thing whereas others see them as two different forms. Occasionally, text and discourse are parallel to each other but often the former is seen as the subordinate of the latter and vice versa. This paper aimed at formulating new definitions of text and discourse in order to clarify the nature of each as well as the relations that may exist between them.  The method applied in this study was by collecting as many as definitions of text and discourse as stated by linguistic experts and quoted in references. These data were then compared and contrasted to find out the similarities and the differences between the objects for drawing a conclusion in the form of definitions and descriptions that precisely represent the characteristics of each. The result shows that, text and discourse share both similarities and differences. At certain level, they can be seen as the same entity but in other conditions one may take position as part of the other.
Language Patterns on Music Festival Posters from the 80s Era to the 2020s Era
Authors: Puspahaty Novita , Rahmawati Putri
Published: September 2024

Differences in eras can affect language patterns in naming posters at music festivals. This study aimed to discover the differences in language patterns in music festival posters from the 80s to the 2020s. At the morphological level, we used Yule's theory (2010) to analyze word formation. Then, at the syntactic level, we used Morley's theory (2000) to examine phrases. We also used a content analysis to examine data collected from newspapers and social media. The results of the study showed that at the morphological level, the most commonly used in naming music festival titles from the 80s to the 2020s is the type of word borrowing and clipping. The borrowing word formation type is used up to 18 times, while the clipping word formation type is used 6 times. In addition, at the syntactic level, the results found are included in the category of noun phrase types from the 80s to the 2020s.
Coarctation of Aorta Masquerading as a Spinal Arteriovenous Malformation: A Case Report
Authors: Badhe Padma Vikram , Varrior Ajith , Waghela Meet , Nagwekar Chandranshu
Published: September 2024

Coarctation of the aorta is a congenital disease involving the cardiovascular system. It has a varied presentation and is often under-diagnosed in clinical practice. The authors report a case of an unusual presentation of coarctation of the aorta with a series of events leading to the final diagnosis. A 28-year-old man presented with complaints of backache and pain in both lower limbs with tingling and numbness for 8 months. He was provisionally diagnosed with spinal arteriovenous malformation based on investigations done elsewhere and was referred to the authors’ hospital for further management. On angiography, the transfemoral catheter and guide wire could not be negotiated beyond the descending thoracic aorta distal to the origin of the left subclavian artery. Transradial access demonstrated the coarctation of the aorta. Coarctation presenting as a spinal pathology is rare and has been described only in few of the literatures, so it is important to recognise it. This article also describes the pathophysiology and radiological features of coarctation.
Association between automatic milking system parameters and intramammary infections in dairy cows at dry-off
Authors: Ongom Jonathan , Okella Hedmon , Ferreira Fernanda C. , Okello Emmanuel
Published: September 2024

Introduction

The current global concern over increasing antimicrobial resistance among animal and human pathogens has motivated efforts to reduce antimicrobial drug use in food animals and its impact on antimicrobial resistance. One such strategy is to use selective dry cow therapy (SDCT) in dairy cows, which involves treating only cows with intramammary infection (IMI) at dry-off. However, efficient methods are needed to identify cows with IMI at dry-off to implement SDCT. Automatic Milking Systems (AMS) data may help farmers identify cows with IMI when individual Somatic Cell Count (SCC) is not routinely tested. This study assessed the correlation between cow-level and quarter-level AMS parameters and IMI at dry-off.

Methods & Results

A total of 733 udder quarters (comprising both Primiparous [PRIM] and Multiparous [MULT] cows) were sampled and categorized for IMI based on bacterial growth and SCC. Data were aggregated both daily and into 7-day and 15-day intervals preceding dry-off. The quarter-level prevalence of bacterial growth at dry-off was 24.28% overall. When stratified by parity, logistic regression analysis at 15 days to dry-off revealed that the average difference in mastitis detection index (MDi) in PRIM, MDi, and standard deviation milk flow rate in MULT were associated with increased odds of IMI at dry-off. Similarly, data from 7 days to dry-off revealed that average peak milk flow rate in PRIM, and MDi in MULT were associated with increased odds of IMI at dry-off. However, an increase in average milk yield was associated with decreased odds of IMI.

Discussion & Conclusion

Our findings underscore the significance of MDi, milk flow rate, peak milk flow rate, and milk yield in predicting IMI at dry-off. Notably, stronger associations were observed with data collected 7 days preceding dry-off. Further research is warranted to refine and validate algorithms amalgamating these variables for precise IMI prediction in cows at dry-off.
Enhancing the photoelectrochemical performance of TiO2 photoanode by employing carbon nanoparticles as electron reservoirs and photothermal materials
Authors: Huang Jing , Huang Yijie , Guo Puwen , Li Yinchang
Published: September 2024

Photoelectrochemical (PEC) water splitting is regarded as a potential technique for converting solar energy. However, the fast charge recombination and slow water oxidation kinetics significantly have hindered its practical application. It is found that an elevation in operation temperature can activate the charge transport in the photoanodes. Here, a strategy was performed that carbon nanoparticles were employed to TiO2 nanorods, acting as electron reservoirs as well as photothermal materials. More specifically, a record photocurrent density of 1.62 mA cm−2 at 1.23 V vs. RHE has been achieved, accompanied by a high charge separation efficiency of 96% and a long-term durability for 8 h. The detailed experimental results reveal that under NIR light irradiation, the synergistic effect between electron storage and temperature rise leads to accelerated charge transport in the bulk and water oxidation kinetics on the surface. This research offers a new perspective on how to boost the PEC performance of photoelectrodes.
Associations of vaginal microbiota with the onset, severity, and type of symptoms of genitourinary syndrome of menopause in women
Authors: Zeng Qianru , Shu Han , Pan Heng , Zhang Yonghong , Fan Ling , Huang Yubin , Ling Li
Published: September 2024

Introduction

Genitourinary syndrome of menopause (GSM) describes the symptoms and signs resulting from the effect of estrogen deficiency on the female genitourinary tract, including genital, urinary, and sexual symptoms. However, besides estrogen deficiency, little is known about the etiology of GSM. The objective of this study was to investigate the effects of vaginal microbiota dysbiosis on the occurrence and development of GSM in perimenopausal and postmenopausal women.

Methods

In total, 96 women were enrolled in this cross-sectional study and clinical data were collected. GSM symptoms were divided into three types: genital, urological, and sexual symptoms. Full-length 16S rRNA gene sequencing using the third-generation PacBio sequencing technology was performed to analyze the vaginal microbiome using vaginal swabs of non-GSM and GSM women with different types of GSM symptoms. Live Lactobacillus Capsule for Vaginal Use (LLCVU) treatment was used to verify the effects of Lactobacillus on GSM symptoms.

Results

We found that 83.58% (56/67) of women experienced GSM symptoms in the perimenopausal and postmenopausal stages. Among these women with GSM, 23.21% (13/56), 23.21% (13/56), and 53.57% (30/56) had one type, two types, and three types of GSM symptoms, respectively. The richness and diversity of vaginal microbiota gradually increased from reproductive to postmenopausal women. There were significant differences in vaginal microbial community among non-GSM women and GSM women with different types of symptoms. Lactobacillus was found to be negatively associated with the onset, severity, and type of GSM while some bacteria, such as Escherichia-shigella, Anaerococcus, Finegoldia, Enterococcus, Peptoniphilus_harei, and Streptococcus, were found to be positively associated with these aspects of GSM, and these bacteria were especially associated with the types of genital and sexual symptoms in GSM women. LLCVU significantly relieved genital symptoms and improved the sexual life of GSM women in shortterm observation.

Conclusions

The onset, severity, and type of GSM symptoms may be associated with changes in vaginal microbiota in perimenopausal and postmenopausal women. Vaginal microbiota dysbiosis probably contributes to the occurrence and development of GSMsymptoms, especially vaginal and sexual symptoms. Lactobacillus used in the vagina may be a possible option for non-hormonal treatment of GSM women with genital and sexual symptoms.

Clinical Trial Registration

https://www.chictr.org.cn/indexEN.html, identifier ChiCTR2100044237.
Study of the causal relationship between gastroesophageal reflux disease and hypertension through two-sample Mendelian randomization analysis
Authors: Li Weige , Wang Qian , Li Wenjie , Liu Xiang , Li Zuobin , Dai Qi
Published: September 2024

Objective

The purpose of this study was to investigate the causal relationship between gastroesophageal reflux disease (GERD) and hypertension using a two-sample Mendelian randomization analysis.

Methods

The associated data of GERD with hypertension were derived from the genome-wide association study (GWAS) database, and two-sample Mendelian randomization (MR) analysis was performed using methods including inverse variance weighting (IVW), MR-Egger, and weighted median (WM) to investigate the causal association between GERD and hypertension.

Results

A total of 16 single nucleotide polymorphisms (SNPs) strongly associated with GERD were screened out, and the IVW suggested a causal relationship between GERD and hypertension (OR: 1.057; 95% CI: 1.044–1.071; P < 0.05). The weighted median also showed a similar relationship (OR: 1.051, 95% CI: 1.032–1.07; P < 0.05). In addition, no heterogeneity or horizontal pleiotropy was observed, suggesting a robustness of the outcome.

Conclusion

There is a positive causal relationship between GERD and hypertension.
Let’s get on-board: a practical framework for designing and implementing educational board games in K-12 classrooms
Authors: Nautiyal Vijit V. , Silverio Sandro A. , Salvador Erika Eunice P.
Published: September 2024

Educational board games are a promising tool for implementing game-based learning to improve the teaching-learning process. However, the absence of comprehensive scholarly guidance on designing educational board games impedes the effective implementation of game-based learning in classrooms. The sparsely available studies on game design frameworks often confine themselves to the design of the educational game itself, without including guidelines for the classroom integration of such games within the design framework. Additionally, the literature often neglects that teachers, burdened by limited time and excessive workload, are often the sole participants in the game design process. To address these gaps, we introduce a practical framework for educators to design and seamlessly integrate educational board games in their classrooms. Our approach prioritizes minimizing additional teacher workload while using game-based learning to foster student-led problem-solving sessions and game revision. Drawing from game design principles and existing literature on game-based learning, we propose a comprehensive framework that guides educators through the design and implementation of educational board games tailored for conducting problem-solving sessions. The framework is validated and refined using qualitative analysis of teacher and student feedback after its seamless integration into the regular mathematics instruction and curriculum of a Philippine K-12 high school. Results indicate positive student experiences and highlight the framework’s efficacy in promoting student engagement, learning outcomes, and teacher convenience. Thematic analysis of student feedback highlights key design preferences and game features that enhance student experiences in GBL sessions. The study contributes to the advancement of GBL methodologies by offering practical guidelines for independent use by educators and promoting exchanges between teacher colleagues. Overall, the proposed framework offers a systematic and feasible approach to designing and implementing educational board games, fostering effective learning experiences in diverse educational contexts.
Information literacy research of technical and vocational education and training in China in the past 10 years: a systematic literature review
Authors: Dai Jiali , Jambari Hanifah , Noh Nur Hazirah , Hisham Mohd Hizwan Mohd
Published: September 2024

Social and economic systematic changes create a new pattern of industrial structure and profession; technical and vocational education and training (TVET) is deeply connected to industrial upgrading and digital transformation because of its high relevance to cultivate emerging professional talents. Information literacy inevitably becomes the prevailing condition of sustainable development of TVET. Through a literature study, this systematic review selected and studied 61 journal articles related to information literacy in the TVET context in China from Web of Science (WOS) databases and China National Knowledge Infrastructure (CNKI) between 2014 and 2023. The main findings include; (a) technological, social and educational circumstances influence which receive extensive attention from researchers, (b) frequent use of narrative inquiry method with lack of empirical studies, (c) themes identified of information literacy among TVET institutions in China shows significant differences as compared to the themes of information literacy in higher education, and the reasons underlying this finding has been critically analysed. This review may interest academics, decision-makers and trainers in improving information literacy education among TVET institutions in China in line with the sophisticated demands of the industry and community.
ATF4-dependent and independent mitokine secretion from OPA1 deficient skeletal muscle in mice is sexually dimorphic
Authors: Streeter Jennifer , Persaud Luis , Gao Jason , Manika Deeraj , Fairman Will , García-Peña Luis Miguel , Marti Alex , Manika Chethan , Gaddi Shreya , Schickling Brandon , Pereira Renata O. , Abel E. Dale
Published: September 2024

Introduction

Reducing Optic Atrophy 1 (OPA1) expression in skeletal muscle in male mice induces Activation Transcription Factor 4 (ATF4) and the integrated stress response (ISR). Additionally, skeletal muscle secretion of Fibroblast Growth Factor 21 (FGF21) is increased, which mediates metabolic adaptations including resistance to diet-induced obesity (DIO) and glucose intolerance in these mice. Although FGF21 induction in this model can be reversed with pharmacological attenuation of ER stress, it remains to be determined if ATF4 is responsible for FGF21 induction and its metabolic benefits in this model.

Methods

We generated mice with homozygous floxed Opa1 and Atf4 alleles and a tamoxifen-inducible Cre transgene controlled by the human skeletal actin promoter to enable simultaneous depletion of OPA1 and ATF4 in skeletal muscle (mAO DKO). Mice were fed high fat (HFD) or control diet and evaluated for ISR activation, body mass, fat mass, glucose tolerance, insulin tolerance and circulating concentrations of FGF21 and growth differentiation factor 15 (GDF15).

Results

In mAO DKO mice, ATF4 induction is absent. Other indices of ISR activation, including XBP1s, ATF6, and CHOP were induced in mAO DKO males, but not in mOPA1 or mAO DKO females. Resistance to diet-induced obesity was not reversed in mAO DKO mice of both sexes. Circulating FGF21 and GDF15 illustrated sexually dimorphic patterns. Loss of OPA1 in skeletal muscle increases circulating FGF21 in mOPA1 males, but not in mOPA1 females. Additional loss of ATF4 decreased circulating FGF21 in mAO DKO male mice, but increased circulating FGF21 in female mAO DKO mice. Conversely, circulating GDF15 was increased in mAO DKO males and mOPA1 females, but not in mAO DKO females.

Conclusion

Sex differences exist in the transcriptional outputs of the ISR following OPA deletion in skeletal muscle. Deletion of ATF4 in male and female OPA1 KO mice does not reverse the resistance to DIO. Induction of circulating FGF21 is ATF4 dependent in males, whereas induction of circulating GDF15 is ATF4 dependent in females. Elevated GDF15 in males and FGF21 in females could reflect activation by other transcriptional outputs of the ISR, that maintain mitokine-dependent metabolic protection in an ATF4-independent manner.
Very early and severe presentation of Triple A syndrome – case report and review of the literature
Authors: Cehic Maja , Mitrovic Katarina , Vukovic Rade , Milenkovic Tatjana , Kovacevic Gordana , Todorovic Sladjana , Panic Zaric Sanja , Cvetkovic Dimitrije , Paripovic Aleksandra , Huebner Angela , Koehler Katrin , Quitter Friederike
Published: September 2024

Triple A syndrome (TAS), also known as Allgrove syndrome (OMIM#231550), is a rare, autosomal recessive disorder characterized by the triad of alacrima, achalasia, and adrenal insufficiency. Additional neurological features may be present in two-thirds of patients, involving central, peripheral, and autonomic nervous system manifestations. TAS is caused by genetic alterations in the AAAS gene on chromosome 12q13, which encodes the nuclear pore complex protein termed ALADIN (ALacrima, Achalasia, aDrenal Insufficiency, and Neurologic disorder). ALADIN plays a crucial role in nucleocytoplasmic transport of specific proteins, including the transport of DNA repair proteins. TAS exhibits significant phenotypic variability in terms of symptom onset, frequency, and severity, often presenting with a progressive clinical course indicative of an underlying degenerative process. In this study, we report the case of an infant with exceptionally early and severe manifestations of triple A syndrome, with a review of the literature. Our patient exhibited the complete classical triad of TAS at six months of age, being among the youngest reported cases of the syndrome. The clinical course was complicated by severe involvement of the autonomic nervous system, neurogenic bladder, and recurrent urinary tract infections. Subsequently, the patient developed acute pancreatitis, leading to multiorgan dysfunction and a fatal outcome at 25 months of age. This case underscores the potential for atypical disease presentations and the need for clinical awareness in diagnosing and managing patients with TAS.