bluuebunny/crossref_metadata_2025 huggingface dataset:
SOLID STATE BATTERIES: CHALLENGES AND PROJECTION (Part 1/2)
Authors: Babaei Azin , LLOPIS SEBASTIAN , ZUBIZARRETA SAENZ DE ZAITEGUI LEIRE , GIL AGUSTI MAYTE , QUIJANO LÓPEZ ALFREDO
Published: June 2023

En este artículo se revisa el estado actual y las perspectivas de futuro de las baterías de estado sólido. Se realiza un estudio centrado en la descripción de los retos y las necesidades para el desarrollo tecnológico para las baterías de estado sólido y las investigaciones destinadas a solventar los retos actuales y futuros. Finalmente, se revisan los proyectos relacionados con este tipo de tecnología dentro del programa Horizon 2020.
IFMIF-DONES AND FUSION ENERGY
Authors: WEBER SUÁREZ MOISÉS
Published: June 2023

Fusion is a safe, sustainable and massive energy source whose profitable exploitation is a huge technological challenge. Over the past seventy years, numerous investigations and major experiments have brought us close enough to a viable solution to now have a well-defined roadmap, supported by two big experiments that will confirm, on the one hand, how fusion energy production should be optimized (ITER project) and, on the other hand, which materials are suitable for use in the most critical areas of future fusion reactors (IFMIF-DONES project). This article aims to convey the magnitude and the challenges faced by the latter.
ANALYSIS OF A NEW TOOL FOR ELECTRODE POSITIONING ON THE SCALP ACCORDING TO THE INTERNATIONAL 10/20 SYSTEM
Authors: FABREGAT SANJUAN ALBERT , PAMIES VILLA ROSA , RIGO VIDAL AGNES , PASCUAL RUBIO VICENC
Published: June 2023

The emergence of non-invasive electromagnetic brain stimulation techniques, together with the improvement of electrophysiological recordings, has led to the need to increase the precision of the localization of cranial points close to their cortical target. In the clinical practice, the most common technique for locating there points on the scalp is the International 10/20 system and tape measure and a marker pen are used to carry out the marking process, before the placement of the electrodes. In this study, we have compared the marking for different electrophysiological tests between the conventional method and a new method based on the EPlacement device. The comparison was made taking into account the time spent on each test, the mean distance error per electrode, the direction of the error using the coordinate sign and, finally, a survey of healthcare staff to get their opinions on the 1S-EP and 2S-EP variants of EPlacement. The study involved 10 healthcare workers, 5 of whom had experience in conventional marking and 5 had experience in using the EPlacement device. 90 markings on dummies and 10 markings on volunteers were performed. Once each marking was completed on the dummies, the distances between the experimental points (marked with the EPlacement and tap measure) and the reference positions from 10/20 system determined by a 3D printed template were measured. The results show that with EPlacement, marking accuracy is increased, marking time is reduced, and healthcare personnel is receptive to adopting this technology.
Keywords: 10/20, EEG, neurophysiology, nasion, inion, tragus, evoked potentials, error, 3D, EPlacement, dummy head, rTMS.
INDUSTRY 4.0 REMOTE LAB BASED ON PIC MICROCONTROLLERS
Authors: MARTIN GUTIERREZ SERGIO , GOMEZ ALVARO , CASTRO GIL MANUEL ALONSO
Published: June 2023

This technical note introduces an analysis of the current remote labs for PIC microcontrollers. Based on the analysis results, the paper describes a remote lab developed by the authors to perform remote PIC programming IoT-oriented practices. This remote lab has been implemented with the Microchip PIC-IoT board. The remote lab based on this Internet of Things device is suitable for its use in educational institutions as a first step to get the students familiar with the kit without the need of having to acquire it. Also, it allows connecting more complex peripherals not easily usable by students at home. This the first remote lab for PIC microcontroller programming.
Roxtuna.
Authors: Marnell Gunnar
Published: June 2023

Intet resumé
Trondhjem Tugt- og Verkshus 1639-1814.
Authors: Bugge Kjeld
Published: June 2023

Intet resumé
Mobile Augmented Reality in Biological Education: Perceptions of Austrian Secondary School Teachers
Authors: Schmidthaler Eva , Anđic Branko , Schmollmüller Mathias , Sabitzer Barbara , Lavicza Zsolt
Published: June 2023

Today's teachers play a critical role in preparing students for the integration of educational technologies, such as augmented reality (AR), into their lessons. It is thought that AR implementation improves collaboration, motivation, and learning outcomes. Considering this, this study aims to determine the teachers’ perceptions of the benefits and obstacles of employing mobile AR applications (mAR) in their biology education, along with suggestions for practice, app developers, and policymakers. Therefore, a mixed-methods study was used to examine Austrian secondary school biology teachers’ opinions. A questionnaire containing open-ended and closed-ended questions was distributed to 35 teachers. Descriptive statistics were employed to process quantitative data, whereas grounded theory was utilized to process qualitative data. According to the findings, biology teachers likely utilize mAR apps to teach about human anatomy or to identify living things (e.g., plant determination). According to the teachers, mAR can improve students’ learning outcomes, motivation, and collaboration, and further their enthusiasm for learning biology. The main obstacles that teachers encounter whilst integrating mAR into their lessons are lack of technical devices, Internet issues, inconsistency with the curriculum, and questionable scientific accuracy of information. Despite the promising results, additional future studies with larger sample sizes are needed.
Exercise rehabilitation for recurrent extraocular muscle movement limitation after pediatric blowout fracture surgery: a case report
Authors: Park Jeong Do , Wee Syeo Young , Kim Se Young
Published: June 2023

White-eyed blowout fractures with extraocular muscle (EOM) entrapment necessitate emergency surgical intervention. However, even after surgery, diplopia or EOM motion limitations may persist due to the incomplete reduction of soft tissue herniation caused by inadequate dissection or unresolved muscle strangulation. In this report, we present a case of postoperative EOM movement limitation in a 5-year-old girl who experienced recurrent restriction in the upward gaze of her right eye 14 days after surgery. Instead of revision surgery, the patient was treated with targeted EOM exercises focusing on the inferior rectus muscle and inferior oblique muscle. The patient was instructed to slowly move her pupils from the central point to the upper and outer sides, then in a straight line from the central point to the lower and inner sides before returning to the center point. On the 28th postoperative day, 2 weeks after initiating the exercises, the patient’s EOM motion fully recovered. This case highlights the effectiveness of EOM exercises as a non-surgical treatment approach for improving recurrent EOM movement limitations in the absence of soft tissue herniation following surgical management of blowout fractures in children.
Cleft lip and palate surgery during COVID-19 pandemic in Indonesia: a 36-month experience at the Bandung Cleft Lip and Palate Center
Authors: Sundoro Ali , Hilmanto Dany , Soedjana Hardisiswo , Lesmana Ronny , Suryadinata Kevin Leonard
Published: June 2023

Background: In Indonesia, the prevalence of cleft lip and palate increased from 0.08% to 0.12% between 2013 and 2018. Children with cleft deformities typically undergo staged surgery. However, the coronavirus disease 2019 (COVID-19) pandemic has had negative impacts on the healthcare sector, including the suspension of elective procedures; this has raised concerns about the safety of performing surgery and the functional consequences of delaying treatment, the latter of which is associated with poor prognosis. The purpose of this study was to report the characteristics of clefts treated by the Bandung Cleft Lip and Palate Center team during the pandemic period.Methods: This brief comparative study based on a chart review was conducted at the Bandung Cleft Lip and Palate Center. We statistically evaluated data from all patients treated between September 2018 and August 2021. Frequency analysis was performed to analyze the average number of each procedure by age before and during the COVID-19 pandemic.Results: Data from 18-month periods before (n = 460) and during (n = 423) the pandemic were compared. Cheiloplasty procedures were examined (pre-pandemic, n = 230; pandemic, n = 248); before the pandemic, 86.1% were performed according to the treatment protocol (patient < 1 year old), and this proportion non-significantly dropped to 80.6% during the pandemic (p = 0.904). Palatoplasty procedures were also compared (pre-pandemic, n = 160; pandemic, n = 139); the treatment protocol (patient 0.5–2 years old) was followed for 65.5% of procedures before the pandemic and 75.5% during the pandemic (p = 0.509). Additionally, 70 (mean age, 7.94 years) revision and other procedures were performed before the pandemic and 36 (mean age, 8.52 years) during the pandemic.Conclusion: The cleft procedures performed at the Bandung Cleft Lip and Palate Center did not significantly change during the COVID-19 pandemic.
The Phenomenon of Legal Awareness: Historical and Philosophical Reception in the Context of Educational Problems
Authors: Akimov Oleg Yur'evich
Published: June 2023

The study of the legal awareness in the educational space presumes its exposition as a universal phenomenon. This phenomenon combines two mutually agreed aspects. One aspect includes the theory of the legal awareness, that is determined with the philosophical reception of such concepts as the natural right and the positive right. The another aspect concerns the practical forms, that help to realize the legal awareness in the educational space by means of the creation of the special educational environment. The theoretical analysis of the phenomenon of the legal awareness shows the complexity of this problem, that connects legal and social sides of the phenomenon. The mutual integration of this directions is possible only on the theoretical level and basis on the grounds of the idealist philosophy by Kant, Hegel, Ilijin. The another possibility of such exposition gives the materialist philosophy primarily the marxism. This state can be explained with the antinomy of the phenomenon of the legal awareness. This antinomy allows the situations, when the special features of the phenomenon do not correspond with each other, but its unity keeps safer. This unity keeps safer by means of the theory of the reflection, that accentuates the material external world. The another way of the realization of this unity is connected with the idealist philosophy, that considers the legal awareness as the special structure- third option that corresponds with the human personality as the potency and the educational environment only realizes this third option. The modern theories of forming of educational environment in the educational space, created by V. V. Rubzov, V. A. Jasvin, V.I. Svobodchikov, V. I. Panov integrate this two approaches and emphasize the dialogical features of educational environment and do not reduce it to the ideal or material grounds.
Representation of the concept «ev-mesken|house-dwelling» in the Crimean Tatar and Russian linguistic picture of the world
Authors: Mamutova Zakiiya , Ibragimova Venera Fevzievna , Nasibullaeva Elina Rasimovna
Published: June 2023

The purpose of this article is to identify the features and common features of the concept "ev (mesken) | house (housing)" as a single mental integrity of the picture of the world, to consider the representations of the analyzed concept in the structure of the Crimean Tatar and Russian languages. The scientific novelty of this work lies in the presentation of the comparative specifics of the characteristics of the concept "ev|hause " in the Crimean Tatar and Russian linguistic picture of the world, for the first time an attempt is made to compare the representations of "ev (mesken) | house (housing)" from a linguocultural point of view. The results obtained showed that the attempt to present the concept of "ev|hause" against the background of two national pictures of the world - the Crimean Tatar and Russian, reflects the most specific features of the national picture of the world in comparison. The analyzed material on the research topic may be of interest for further scientific research in the field of linguoculturology, ethnoculturology and intercultural communication.
A back-door insight into the modulation of Src kinase activity by the polyamine spermidine
Authors: Rossini Sofia , Gargaro Marco , Scalisi Giulia , Bianconi Elisa , Ambrosino Sara , Panfili Eleonora , Volpi Claudia , Orabona Ciriana , Macchiarulo Antonio , Fallarino Francesca , Mondanelli Giada
Published: June 2023

Src is a protein tyrosine kinase commonly activated downstream of transmembrane receptors and plays key roles in cell growth, migration, and survival signaling pathways. In conventional dendritic cells (cDCs), Src is involved in the activation of the non-enzymatic functions of indoleamine 2,3-dioxygenase 1 (IDO1), an immunoregulatory molecule endowed with both catalytic activity and signal transducing properties. Prompted by the discovery that the metabolite spermidine confers a tolerogenic phenotype on cDCs that is dependent on both the expression of IDO1 and the activity of Src kinase, we here investigated the spermidine mode of action. We found that spermidine directly binds Src in a previously unknown allosteric site located on the backside of the SH2 domain and thus acts as a positive allosteric modulator of the enzyme. Besides confirming that Src phosphorylates IDO1, here we showed that spermidine promotes the protein–protein interaction of Src with IDO1. Overall, this study may pave the way toward the design of allosteric modulators able to switch on/off the Src-mediated pathways, including those involving the immunoregulatory protein IDO1.
Short-range interactions between fibrocytes and CD8+ T cells in COPD bronchial inflammatory response
Authors: Eyraud Edmée , Maurat Elise , Sac-Epée Jean-Marc , Henrot Pauline , Zysman Maeva , Esteves Pauline , Trian Thomas , Dupuy Jean-William , Leipold Alexander , Saliba Antoine-Emmanuel , Bégueret Hugues , Girodet Pierre-Oliver , Thumerel Matthieu , Hustache-Castaing Romain , Marthan Roger , Levet Florian , Vallois Pierre , Contin-Bordes Cécile , Berger Patrick , Dupin Isabelle
Published: June 2023

Bronchi of chronic obstructive pulmonary disease (COPD) are the site of extensive cell infiltration, allowing persistent contacts between resident cells and immune cells. Tissue fibrocytes interaction with CD8
+
T cells and its consequences were investigated using a combination of
in situ
,
in vitro
experiments and mathematical modeling. We show that fibrocytes and CD8
+
T cells are found in vicinity in distal airways and that potential interactions are more frequent in tissues from COPD patients compared to those of control subjects. Increased proximity and clusterization between CD8
+
T cells and fibrocytes are associated with altered lung function. Tissular CD8
+
T cells from COPD patients promote fibrocyte chemotaxis via the CXCL8-CXCR1/2 axis. Live imaging shows that CD8
+
T cells establish short-term interactions with fibrocytes, that trigger CD8
+
T cell proliferation in a CD54– and CD86-dependent manner, pro-inflammatory cytokines production, CD8
+
T cell cytotoxic activity against bronchial epithelial cells and fibrocyte immunomodulatory properties. We defined a computational model describing these intercellular interactions and calibrated the parameters based on our experimental measurements. We show the model’s ability to reproduce histological ex vivo characteristics, and observe an important contribution of fibrocyte-mediated CD8
+
T cell proliferation in COPD development. Using the model to test therapeutic scenarios, we predict a recovery time of several years, and the failure of targeting chemotaxis or interacting processes. Altogether, our study reveals that local interactions between fibrocytes and CD8
+
T cells could jeopardize the balance between protective immunity and chronic inflammation in bronchi of COPD patients.
Transcriptomic profiling of tissue environments critical for post-embryonic patterning and morphogenesis of zebrafish skin
Authors: Aman Andrew J. , Saunders Lauren M. , Carr August A. , Srivatsan Sanjay R. , Eberhard Colten D. , Carrington Blake , Watkins-Chow Dawn , Pavan William J. , Trapnell Cole , Parichy David M.
Published: June 2023

Pigment patterns and skin appendages are prominent features of vertebrate skin. In zebrafish, regularly patterned pigment stripes and an array of calcified scales form simultaneously in the skin during post-embryonic development. Understanding mechanisms that regulate stripe patterning and scale morphogenesis may lead to discovery of fundamental mechanisms that govern development of animal form. To learn about cell types and signaling interactions that govern skin patterning and morphogenesis we generated and analyzed single cell transcriptomes of skin from wild-type fish as well as fish having genetic or transgenically induced defects in squamation or pigmentation. These data reveal a previously undescribed population of epidermal cells that express transcripts encoding enamel matrix proteins, suggest hormonal control of epithelial-mesenchymal signaling, clarify the signaling network that governs scale papillae development, and identify a critical role for the hypodermis in supporting pigment cell development. Additionally, these comprehensive single-cell transcriptomic data representing skin phenotypes of biomedical relevance should provide a useful resource for accelerating discovery of mechanisms that govern skin development and homeostasis.
DnaJC7 specifically regulates tau seeding
Authors: Perez Valerie Ann , Sanders David W , Mendoza-Oliva Ayde , Stopschinski Barbara Elena , Mullapudi Vishruth , White Charles L , Joachimiak Lukasz A , Diamond Marc I
Published: June 2023

Neurodegenerative tauopathies are caused by accumulation of toxic tau protein assemblies. This appears to involve template-based seeding events, whereby tau monomer changes conformation and is recruited to a growing aggregate. Several large families of chaperone proteins, including Hsp70s and J domain proteins (JDPs), cooperate to regulate the folding of intracellular proteins such as tau, but the factors that coordinate this activity are not well known. The JDP DnaJC7 binds tau and reduces its intracellular aggregation. However, it is unknown whether this is specific to DnaJC7 or if other JDPs might be similarly involved. We used proteomics within a cell model to determine that DnaJC7 co-purified with insoluble tau and colocalized with intracellular aggregates. We individually knocked out every possible JDP and tested the effect on intracellular aggregation and seeding. DnaJC7 knockout decreased aggregate clearance and increased intracellular tau seeding. This depended on the ability of the J domain (JD) of DnaJC7 to stimulate Hsp70 ATPase activity, as JD mutations that block this interaction abrogated the protective activity. Disease-associated mutations in the JD and substrate binding site of DnaJC7 also abolished its protective activity. DnaJC7 thus specifically regulates tau aggregation in cooperation with Hsp70.
Intrinsic protein disorder is insufficient to drive subnuclear clustering in embryonic transcription factors
Authors: Hannon Colleen E , Eisen Michael B
Published: June 2023

Modern microscopy has revealed that core nuclear functions, including transcription, replication, and heterochromatin formation, occur in spatially restricted clusters. Previous work from our lab has shown that subnuclear high-concentration clusters of transcription factors may play a role in regulating RNA synthesis in the early Drosophila embryo. A nearly ubiquitous feature of eukaryotic transcription factors is that they contain intrinsically disordered regions (IDRs) that often arise from low complexity amino acid sequences within the protein. It has been proposed that IDRs within transcription factors drive co-localization of transcriptional machinery and target genes into high-concentration clusters within nuclei. Here, we test that hypothesis directly, by conducting a broad survey of the subnuclear localization of IDRs derived from transcription factors. Using a novel algorithm to identify IDRs in the Drosophila proteome, we generated a library of IDRs from transcription factors expressed in the early Drosophila embryo. We used this library to perform a high-throughput imaging screen in Drosophila Schneider-2 (S2) cells. We found that while subnuclear clustering does not occur when the majority of IDRs are expressed alone, it is frequently seen in full-length transcription factors. These results are consistent in live Drosophila embryos, suggesting that IDRs are insufficient to drive the subnuclear clustering behavior of transcription factors. Furthermore, the clustering of transcription factors in living embryos was unaffected by the deletion of IDR sequences. Our results demonstrate that IDRs are unlikely to be the primary molecular drivers of the clustering observed during transcription, suggesting a more complex and nuanced role for these disordered protein sequences.
Intrinsic protein disorder is insufficient to drive subnuclear clustering in embryonic transcription factors
Authors: Hannon Colleen E. , Eisen Michael B.
Published: June 2023

Modern microscopy has revealed that core nuclear functions, including transcription, replication, and heterochromatin formation occur in spatially restricted clusters. Previous work from our lab has shown that subnuclear high-concentration clusters of transcription factors may play a role in regulating RNA synthesis in the early
Drosophila
embryo. A nearly ubiquitous feature of eukaryotic transcription factors is that they contain intrinsically disordered regions (IDRs) that often arise from low complexity amino acid sequences within the protein. It has been proposed that IDRs within transcription factors drive co-localization of transcriptional machinery and target genes into high concentration clusters within nuclei. Here we test that hypothesis directly, by conducting a broad survey of the subnuclear localization of IDRs derived from transcription factors. Using a novel algorithm to identify IDRs in the
Drosophila
proteome, we generated a library of IDRs from transcription factors expressed in the early
Drosophila
embryo. We used this library to perform a high throughput imaging screen in
Drosophila
S2 cells. We found that while subnuclear clustering does not occur when the majority of IDRs are expressed alone, it is frequently seen in full length transcription factors. These results are consistent in live
Drosophila
embryos, suggesting that IDRs are insufficient to drive the subnuclear clustering behavior of transcription factors. Furthermore, the clustering of transcription factors in living embryos was unaffected by the deletion of IDR sequences. Our results demonstrate that IDRs are unlikely to be the primary molecular drivers of the clustering observed during transcription, suggesting a more complex and nuanced role for these disordered protein sequences.
Extracts from Acta Societatis Regiæ Scientiarum Upsaliensis Ab Anno DMCCXLIV Ad MDCCL
Authors: Hiorter Olof Peter
Published: June 2023

The file is a facsimile of extracts from the Acta Societatis Regiæ Scientiarum Upsaliensis for the years 1744 to 1750 (printed 1751), comprising the Title Page, Editor's Preface, Table of Contents and an article on the aurora borealis by Olof Peter Hiorter. For a detailed summary of contents, see the introduction by Per Pippin Aspaas.
Macroproyectos y excepcionalidad en el Caribe colombiano. El Gran Malecón del Río Magdalena en Barranquilla
Authors: Duque-Franco Isabel
Published: June 2023

El artículo aborda la excepcionalidad como característica de los macroproyectos urbanos y como perspectiva de análisis. Tomando como referencia el Gran Malecón del Río Magdalena en Barranquilla – Colombia, el artículo examina los marcos de excepcionalidad que sirven de sustento a los macroproyectos, considerando su dimensión narrativa, las prácticas de excepción y sus efectos espaciales. Mediante de entrevistas, análisis documental y observación en campo el artículo establece la relevancia del contexto local en la formulación e implementación del macroproyecto. El trabajo concluye que la naturaleza excepcional que rodea a los macroproyectos es un proceso urbano espacialmente situado condicionado por la configuración de actores, dinámicas y prácticas locales.
Antioxidant and Antimicrobial Activity of Psidium guajava (Pomifera and Pyrifera) Aqueous Leaf Extract Varieties’
Authors: Keddy Grace Gakii , Kareru Patrick Gachoki , Wanakai Sammy Indire , Karenju Mercy Wanjuki , Kisoi George Kiprono , Njenga Peter Lemei
Published: June 2023

Aims: Psidium guajava (Pomifera (red) and Pyrifera (white)) is commonly used in traditional medicine to treat gastrointestinal disorders. In this study, the antioxidant and antimicrobial activity of methanol extracts of P. guajava (Pomifera (Red) and Pyrifera (White) leave varieties were investigated.

Methodology:  The total phenolic (TPC) and flavonoid (TFC) contents and antioxidant capacities in terms of 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging, were determined, and the correlations among the results were assessed. The antimicrobial activity was assessed through agar disc diffusion assays.

Results: Phytochemical screening showed that the extracts had alkaloids, glycosides, saponins, triterpenoids, phenols, and flavonoids in different abundances. The aerial part- (Pomifera (red) and Pyrifera (white)) extract contained 106.502.97 and 122.072.73 mg/g in QAE phenolic content, 2650.6527.48 and 2486.829.10 mg/g in RE of flavonoids, 17.860.19 and 10.160.07 mg/g in TAE of Tannins, 69.500.14 and 10.500.01 alkaloid content, and 7.25.500.11 and 17.750.09 saponin content and displayed significant antioxidant capacity in the DPPH (IC50 = 52.17 ± 7.30 μg/mL) assay. By contrast, the P. guajava Pyrifera (white) extract contained high amounts of TPC (87.72 ± 7.75 mg GAE/g) and TFC (25.60 ± 1.57 mg QE/g). The leaf extract showed the highest inhibitory activity against highest activity was observed against E. Coli, S.E, and S. aureus (14, 15, and 16) respectively. GC-MS revealed presence of Sesquiterpenes, terpenes, and triterpenes. The leaves also contain vitamins of measurable amounts. Generally, the extracts evaluated showed potent antifungal activity against selected bacterial strains.

Conclusion: The results showed that P. guajava (Pomifera (red) and Pyrifera (white)) possesses different phytochemicals displaying significant antioxidant and antimicrobial activities, thus lending credence to its use in traditional medicine.
Effect of Tillage and Weed Management Practices on Dry Matter, Yield and Nutrient Uptake by Plant and Depletion by Weed in Lentil Crop (Lens culinaris M.)
Authors: Birla Devilal , Pandey I. B. , Gajanand  , Singh Devendra , Ranjan Prabhat , Solanki Kavita , Sandeep S. N.
Published: June 2023

Aims: To evaluate the impact of tillage and weed management techniques on Plant dry weight, Yield, nutrient uptake by plant and depletion by weed in lentil crop (Lens culinaris M.).

Place and Duration of Study: A field study was conducted at Research Farm of Tirhut College of Agriculture, Dr. Rajendra Prasad Central Agricultural University, Pusa, Bihar, India, from Oct 2020 to Mar 2021.

Methodology: The experiment followed a split-plot design with three replications. The main plots consisted of three tillage practices (M1: Zero tillage, M2: Minimum tillage, and M3: Conventional tillage), while subplots included five weed management practices [T1: control, T2: 1 hand weeding at 20 DAS, T3: chlorimuron-ethyl 4 g/ha (pre-emergence) + paddy straw mulching (5.0 t/ha), T4: quizalofop-ethyl 40 g/ha at 20 DAS (post-emergence) and T5: chlorimuron-ethyl 4 g/ha (pre-emergence) + quizalofop-ethyl 40 g/ha at 20 DAS (post-emergence)].

Results: Among the tillage practices conventional found most effective in term of increasing plant dry weight, grain yield, straw yield, nutrient uptake by crop while effectively reduce the weed dry matter and nutrient depletion by the weed. Among the weed management practices hand weeding proved to be the most effective weed management practice, leading to higher plant dry matter, grain yield, straw yield and nutrient uptake by crop and least weed dry matter weight and nutrient depletion by weeds. Among the chemical weeding chlorimuron ethyl (PE) + paddy straw mulching showed comparable effectiveness to hand weeding in all the parameters. These results highlight the importance of tillage practices and effective weed management techniques in optimizing plant growth, yield, nutrient uptake, and weed control.
Managing Complex Investment Procedures
Authors: Subiyanto Effnu
Published: June 2023

This study aims to obtain notice, knowledge, and practical experience to help-guiding-investors on how to anticipate and deal with complicated investment procedures in Indonesia. As a developing country, Indonesia is well known for applying complicated and overlapped procedures. The complex procedures start in the beginning phase, during construction, and even arise again when the construction phase has nearly completed to enter operation. The methods presented are based on mixed interdisciplinary analyses. In preliminary, we enhanced the initial data using case studies. In the next phase, we validate through an exploratory study combined with an analytical hierarchy process. We provide an additional stage of descriptive analysis before we conclude as research findings. The results found that investors must first build a bolstered project team to address the complicated procedures. The team has addressed five stages that must be carefully handled: the preparation phase, procurement stage, groundbreaking and construction period, commissioning time, and the scheduled closing ceremonies. The most attention is addressing the preparation stage. Despite being proven in the cement projects, the findings can be implemented in other construction projects with several adjustments. This study demonstrated better building governance for societies and Nations and would be beneficial to improve the fairness climate for the Government of Indonesia.
Examining New Media Consumption from the standpoint of OTT Streaming Services
Authors: Karunakaran Rajarathi , S Selvabaskar , M Karthik Ram , R Guhan
Published: June 2023

The study deals with consumer behavior in consuming OTT media streaming services in India. Nine variables of motivations such as Relaxation, Companionship, Habit, Pastime, Entertainment, Social interaction, Information, Arousal, and Escape are studied, which affect the intention to continue to subscribe to these services. Tools such as frequency analysis, One Way ANOVA, and Regression analysis are used to study the demographic characteristics, levels of motivation, differences between the demographic factors and variables of motivation, and the effect of variables of motivation on intention to continue subscription studied, respectively. The sample size was 309. Entertainment was the variable with the highest level of motivation. Except for Entertainment and Escape, all the variables significantly differed in different demographic groups concerning Gender, Age, and Education. Relaxation, Companionship, Habit, Information sharing, and Escape have been found to have a significant relationship with the intention to continue the subscription.
ENVIRONMENTAL, SOCIAL AND GOVERNANCE (ESG)
Authors: Serra de Souza Daniel , De Oliveira Teresa
Published: June 2023

O presente artigo tem por objetivo geral analisar o enquadramento de políticas sociais em favor da comunidade LGBTQIAPN+ em empresas brasileiras e o valor agregado por tal comportamento, e tem por objetivos específicos discutir a realidade dos indivíduos da comunidade LGBTQIAPN+ em relação às empresas, debater a adequação de padrões e políticas no modelo ESG e discutir a importância das empresas de se tornarem aliadas de causas sociais. A abordagem do presente estudo foi qualitativa descritiva, por análise documental e revisão bibliográfica, onde se concluiu que a comunidade LGBTQIAPN+ ainda sofre com ações discriminatórias nas empresas, e, os métodos ESG podem ser um caminho que estabeleça uma solução e uma prosperidade positiva a longo prazo para o grupo social em questão, bem como o desenvolvimento do valor das empresas que adotam tais condutas.
ADOÇÃO HOMOAFETIVA
Authors: Silva de Oliveira Ludmylla , Pinho Carlos Eduardo Romeiro
Published: June 2023

Este artigo tem como finalidade discutir um tema importante dentro do Direito de Família, qual seja, adoção de crianças e adolescentes por casais homoafetivos, já que se trata de uma temática com relevância social e judicial na atualidade. Esse trabalho tem por escopo a pesquisa bibliográfica, por meio da revisão narrativa, realizada em livros, artigos, Constituição Federal e Estatuto da Criança e Adolescente (ECA) com uma abordagem qualitativa a respeito das novas famílias constituídas, possibilidade jurídica de ocorrer a referida adoção, preconceito sofrido por esses casais e, consequentemente, a burocracia que esse procedimento possui e possível averbação no registro de nascimento. Mostra-se, assim, que qualquer casal, independente da orientação sexual, os casais homoafetivos têm o direito de constituir uma família.
O RECONHECIMENTO DA VIOLÊNCIA PSICOLÓGICA PELO ORDENAMENTO JURÍDICO BRASILEIRO COMO UM MECANISMO DE ENFRENTAMENTO À VIOLÊNCIA DE GÊNERO NO BRASIL
Authors: Adono da Silva Juliana
Published: June 2023

A violência de gênero na América Latina tem sido combatida historicamente pelas mulheres organizadas politicamente em movimentos sociais de pautas feministas, bem como pela própria Academia, especificamente no campo dos estudos de gênero. O sistema jurídico vigente, por sua vez, encontra respaldo teórico e político no campo dos estudos de gênero e das teorias que dialogam com as especificidades da violência de gênero em virtude dos problemas sociais e dos antagonismos de classe e raça/etnia presentes na sociedade brasileira. A partir de tal estrutura teórica e política que fundamenta os eixos da violência de gênero situada no Brasil, o sistema jurídico vigente fórmula, mediante a Lei Maria da Penha, o reconhecimento da violência de gênero e as suas diferentes formas de combate. Contudo, apenas em 2018 foi reconhecida, nesse contexto, a violência psicológica como um problema de gênero e de ordem pública. Diante disso, o presente trabalho busca demonstrar o reconhecimento da violência psicológica pelo ordenamento jurídico brasileiro como um mecanismo de enfrentamento à violência de gênero no Brasil, uma vez que pode constituir-se, sobretudo, como arcabouço jurídico de reivindicação de direitos das mulheres pelos diferentes movimentos feministas. Para tanto, realizou-se pesquisa bibliográfica, com base em fontes primárias e secundárias de análise. Conclui-se que, com base nas teorias que fundamentam o campo dos estudos de gênero, o reconhecimento jurídico-legal da violência psicológica como uma forma de violência doméstica e familiar contra a mulher apresenta-se como mecanismo legítimo de enfrentamento à violência de gênero no país.
Transforming Specialty Care Delivery and Payment Under Global Budgets—Insights from the Provision of Surgical Services in Maryland
Authors: Kadakia Kushal T. , Keating Nancy L. , Offodile Anaeze C.
Published: June 2023

This Viewpoint discusses Maryland’s global budget revenue model, which centrally regulates reimbursement rates for all payers via a hospital-specific, prospectively set cap on total annual revenue across all care sites.
Characterization of the Landscape of Joint MD/MBA Programs in the US, 2002 to 2022
Authors: Laditi Folawiyo , Sun Wilton , Forman Howard P.
Published: June 2023

This cross-sectional study characterizes the landscape of joint MD/MBA programs in the US from 2002 to 2022.
Circular Dichroism and Linear Dichroism
Authors: Rodger Alison , Chubb Joel J.
Published: June 2023

Circular dichroism(CD) is the difference in absorption, , of left and right circularly polarized light:For randomly oriented systems such as solutions, only chiral molecules will show any CD intensity corresponding to their absorption bands. Chiral is derived from the Greek word χϵιρ meaning hand and describes something that cannot be superposed on its mirror image by rotation. Two molecules that are mirror images of each other are often referred to as enantiomers and equimolar mixtures of two enantiomers form a racemic mixture which has no net CD intensity in solution. CD can be used to analyze chiral structures, such as a protein secondary structure, and to probe interactions between chiral molecules and other molecules.

Linear dichroism(LD) is the difference in absorption of light linearly polarized parallel and perpendicular to an orientation axis:LD can be used to provide orientation information about subunits of a molecular system such as small molecules absorbed onto stretched films, flow‐oriented DNAs and fibrous proteins, and lipid bilayer systems.

Both circular and LD are absorbance techniques and most CD instruments will also measure LD. Both CD and LD can also be enhanced by fluorescence detection with either incident circularly or linearly polarized light (fluorescence detected circular and linear dichroism) and/or measurement of the circular or linear nature of the emitted light.
Homicide as the first conviction: A retrospective cohort study
Authors: Bojanić Lana , Baird Alison , Ash Kosturika , Shaw Jenny
Published: June 2023

The association between previous convictions and perpetrating homicide has been previously described but little is known about the characteristics of homicide offenders without previous convictions. By utilizing the unique database on homicide offenders held by the National Confidential Inquiry into Suicide and Safety in Mental Health, this study aimed to describe the sample of homicide perpetrators in England and Wales who have committed homicide as their first offense based on their sociodemographic and clinical characteristics. Compared with those with previous convictions, homicide offenders without previous convictions were more likely to be female and a member of an ethnic minority group. More of those without previous convictions belonged to the youngest (<25) and oldest (>55) age groups and were more likely to kill somebody family member or a spouse. Schizophrenia and other delusional disorders as well as affective disorders were more prevalent in those without previous convictions as were mental illness/insanity as a circumstance in homicide, but those without previous convictions were less likely to have been in previous contact with mental health services. There are clear sociodemographic and clinical differences between homicide perpetrators with and without previous convictions. Implications of these findings are discussed.
Patient Perceptions of Rheumatoid Arthritis Blood Work: A Cross‐Sectional Survey in the ArthritisPower Registry
Authors: Nowell William B. , Venkatachalam Shilpa , Gavigan Kelly , George Michael D. , Withers Johanna B. , Stradford Laura , Rivera Esteban , Curtis Jeffrey R.
Published: June 2023

Objective

To examine how patients with rheumatoid arthritis (RA) perceive RA‐related laboratory testing and the potential utility of a blood test to predict treatment response to a new RA medication.

Methods

ArthritisPower members with RA were invited to participate in a cross‐sectional survey on reasons for laboratory testing plus a choice‐based conjoint analysis exercise to determine how patients value different attributes of a biomarker‐based test to predict treatment response.

Results

Most patients perceived that their doctors ordered laboratory tests to check for active inflammation (85.9%) or assess medication side effects (81.2%). The most commonly ordered blood tests used to monitor RA were complete blood counts, liver function tests, and those measuring C‐reactive protein (CRP) and erythrocyte sedimentation rate. Patients felt CRP was most helpful in understanding their disease activity. Most worried their current RA medication would eventually stop working (91.4%) and they would waste time trying a new RA medication that may not work for them (81.7%). For patients who would require a future change in RA treatment, a majority (89.2%) reported that they would be very/extremely interested in a blood test that could help predict whether such new medication would be effective. Highly accurate test results (improving the chance RA medication will work from 50% to 85–95%) were more important to patients than low out‐of‐pocket cost (<$20) or minimal wait time (<7 days).

Conclusions

Patients consider RA‐related blood work important for monitoring of inflammation and medication side effects. They worry about treatment effectiveness and would undergo testing to accurately predict treatment response.
‘In the Womb Yet Out‐of‐Doors’: Penumbra and the Spaces In‐Between
Authors: Kite Stephen
Published: June 2023

In a wide‐ranging and erudite article that is historical, cultural and philosophical, Stephen Kite explores the experiential nature of the penumbra. He reminds us of some of architecture's most celebrated spaces where subdued light calms architectural vistas. Flooding us with notable examples, he examines the penumbra in terms of sublimity, prospect and refuge, and psychoanalysis.
Charged Space: The Anatomy of the In‐between
Authors: Benedito Silvia
Published: June 2023

Co‐founder of design practice OFICINAA, Silvia Benedito highlights alternative ontologies of ‘void’ and ‘penumbra’ – as spaces of expectation and opportunity within which to create areas and objects that exploit these notions in beneficial ways. The ensuing atmospheres cosset natural resource conservation and human delight, related spaces of umbra/penumbra that formed the basis of her studio's Beastie project in New York.
Efficiency Versus Game: Twilight Spaces for Homo Ludens
Authors: Mazzanti Giancarlo
Published: June 2023

Modernist dogma declares that ‘form follows function’, which historically has led to the design of buildings that tightly prescribe what can happen where and when. These uni‐functional spaces often lack a sense of happy expediency and joy. Columbian architect Giancarlo Mazzanti believes spaces and buildings should occupy a twilight zone that facilitates changes of function, is performative, and encourages unexpected social interactions between users and the city. Here he explains some of his firm's spatial tactics.
The Intimacy of Neglect: Thresholds, Interconnectedness and Unexpected Glimpses
Authors: Neri Lyndon , Hu Rossana
Published: June 2023

Architects Lyndon Neri and Rossana Hu situate the output of their practice, Neri&Hu, in spaces of liminality, subverting traditional typologies of buildings and the city, and blurring the boundary conditions. Their spatial and material investigations use Shanghai as a palimpsest microcosm, its historical, cultural and contemporary architectural accretions there to be reimaged and manipulated.
Things In Themselves: The X‐Ray and Its Embodied Space
Authors: Robinson Paul O
Published: June 2023

At the dawn of the 20th century, the development of the X‐ray and new‐found visions of the interior of bodies inspired artists including Marcel Duchamp. Visual artist and architect Paul O Robinson explores these ‘bones and organs’ within contemporary contexts, artistically exploiting the shadowy, invisible world of interiority, visible exterior form and the uncanny correspondence between them through transformative spatial and material manifestations.
Projecting the Indeterminate and Enigmatic: The Painting of Marco Tirelli
Authors: Soldaini Antonella
Published: June 2023

Curator Antonella Soldaini describes the work of Italian artist Marco Tirelli. His enigmatic spatial speculations force us to abandon our usual optical protocols of assessing art, instead bidding us to enter a space of indeterminacy. Our unfamiliarity with the material presence in the work is conducted by the artist's mastery of light, shadow and penumbra, producing a sense of mystery and infinity.
Fabrication and Training of 3D Conductive Polymer Networks for Neuromorphic Wetware
Authors: Hagiwara Naruki , Asai Tetsuya , Ando Kota , Akai‐Kasaya Megumi
Published: June 2023

The human brain possesses an exceptional information processing capability owing to the 3D and dense network architecture of numerous neurons and synapses. Brain‐inspired neuromorphic hardware can also benefit from 3D architectures, such as high integration of circuits and acquisition of highly complex dynamical systems. In this study, for future 3D neuromorphic engineering, 3D conductive polymer networks consisting of poly(3,4‐ethylenedioxy‐thiophene) doped with poly(styrene sulfonate) anions (PEDOT:PSS) are successfully and stably fabricated between multiple electrodes from scratch in precursor solution by electropolymerization. The networks efficiently emulate the 3D local connections between neighboring neurons observed in the cortex. This novel technology, which allows 3D conductive wiring only between desired electrodes, is unprecedented and has potential as an underlying technology for 3D integration. Furthermore, the experimental results also conclusively prove that conductance modification can be performed by manipulating the physical and chemical properties of 3D branch‐wired conductive polymer wires, thus demonstrating for the first time the feasibility of neuromorphic wetware with enhanced biological plausibility in the subsequent post‐Moore era.
A Large Bandgap Organic Salt Dopant for Sn‐Based Perovskite Thin‐Film Transistor
Authors: Go Ji‐Young , Byeon Gwon , Choi Taesu , Yang Shuzhang , Li Wenwu , Noh Yong‐Young
Published: June 2023

Metal halide perovskite optoelectronic devices have made significant progress over the past few years, but precise control of charge carrier density through doping is essential for optimizing these devices. In this study, the potential of using an organic salt, N,N‐dimethylanilinium tetrakis(pentafluorophenyl)borate, as a dopant for Sn‐based perovskite devices, is explored. Under optimized conditions, the thin film transistors based on the doped 2D/3D perovskite PEAFASnI3 demonstrate remarkable improvement in hole mobility, reaching 7.45 cm2V−1s−1 with a low subthreshold swing and the smallest sweep hysteresis (ΔVhysteresis = 2.27 V) and exceptional bias stability with the lowest contact resistance (2.2 kΩ cm). The bulky chemical structure of the dopant prevents it from penetrating the perovskite lattice and also surface passivation against Sn oxidation due to its hydrophobic nature surface. This improvement is attributed to the bifunctional effect of the dopant, which simultaneously passivates defects and improves crystal orientation. These findings provide new insights into potential molecular dopants that can be used in metal halide perovskite devices.