bluuebunny/crossref_metadata_2025 huggingface dataset:
Reporte de caso: trombosis venosa cerebral en un paciente con virus de inmunodeficiencia humana
Authors: Ferrer-Valencia Valentina , Guevara-Pulido Freddy Orlando , Medina-Debedout María Isabel
Published: April 2021

La trombosis venosa cerebral (TVC) es una presentación clínica poco común del tromboembolismo venoso caracterizada por cefalea, crisis convulsivas, déficits neurológicos focales y papiledema. El diagnóstico es confirmado con Tomografía axial computarizada (TAC) de cráneo y Resonancia magnética nuclear (RMN) cerebral. La TVC tiene una relación importante con el virus de inmunodeficiencia humana (VIH), ya que los pacientes VIH positivos cursan con hiperviscosidad sanguínea, alteraciones de factores anticoagulantes endógenos y riesgo de sobreinfección, entre otros; que predisponen a estados protrombóticos y lesión vascular como lo es la TVC. El tratamiento de la TVC es terapia anticoagulante, por lo general se utiliza heparina no fraccionada o heparina de bajo peso molecular para la fase aguda y anticoagulantes orales como la warfarina para el mantenimiento posterior. Reportamos el primer caso documentado de TVC en un paciente VIH positivo en Colombia.
Morten Qvenild – The HyPer(sonal) Piano Project
Authors: Morten Qvenild
Published: April 2021

Towards a (per)sonal topography of
grand piano and electronics

How can I develop a grand piano with live electronics through iterated development loops in the cognitive technological environment of instrument, music, performance and my poetics?

The instrument I am developing, a grand piano with electronic augmentations, is adapted to cater my poetics. This adaptation of the instrument will change the way I compose. The change of composition will change the music. The change of music will change my performances. The change in performative needs will change the instrument, because it needs to do different things. This change in the instrument will show me other poetics and change my ideas. The change of ideas demands another music and another instrument, because the instrument should cater to my poetics. And so it goes… These are the development loops I am talking about.

I have made an augmented grand piano using various music technologies. I call the instrument the HyPer(sonal) Piano, a name derived from the suspected interagency between the extended instrument (HyPer), the personal (my poetics) and the sonal result (music and sound). I use old analogue guitar pedals and my own computer programming side by side, processing the original piano sound. I also take out control signals from the piano keys to drive different sound processes. The sound output of the instrument is deciding colors, patterns and density on a 1x3 meter LED light carpet attached to the grand piano. I sing, yet the sound of my voice is heavily processed, a processing decided by what I am playing on the keys. All sound sources and control signal sources are interconnected, allowing for complex and sometimes incomprehensible situations in the instrument´s mechanisms.

Credits:
First supervisor: Henrik Hellstenius
Second Supervisors: Øyvind Brandtsegg and Eivind Buene
Cover photo by Jørn Stenersen, www.anamorphiclofi.com
All other photo, audio and video recording/editing by Morten Qvenild, unless stated.
The soloist in contemporary piano concerti
Authors: Ellen Kristine Ugelvik
Published: April 2021

The project grew out of a need to improve my ability to tackle challenges I had faced playing contemporary piano concerti. The embodying of new aesthetics is a great challenge in premieres of new works. While the soloist has great potential for expressing personal artistic ideas within a large-scale concert-hall environment, the classical pianist education just does not cover all challenges of performing brand new concerti. The new music suffers. The general lack of contemporary music in educational repertoires has consequences for how the field of classical music develops, what kind of music we value, how we work and what kind of music we play and listen to in a musical society.

I wanted to explore the potential of my role and investigate how I could behave and play to help to improve the sounding result of new piano concerti. I created this project with the overarching research question: Which abilities do I need to develop further, and to enable a progressive soloist role when faced with challenges in entirely new music, and what are the extended effects of such an expanded role awareness?

As the project moved forward, this progressive role awareness, I discovered, was useful to me by giving me greater flexibility and confidence about the massive collective apparatus surrounding the new piano concerti.

The project is based around five new piano concerti I have premiered at national and international venues: Diamond Dust by D. Fujikura, Konsertstykke i tre deler by M. Hegdal, at the tips of my fingers / on the tip of my tongue by B.L. Thorsen, Wowen Fingerprints by T.B. Ulvo and Theory of the Subject by T. Reinholdtsen. Through the evolution of these works, I examine the role of the soloist in all the processes of musical creation, from initialization to realisation in performance.

The research material provides insights into how new music is dealt with in the standard classical music world. I provide rare awareness of the role of the soloist and suggest several improvements of how we lay the foundations for premiering new music. A central outcome of my project is a ‘toolbox’ of proposed techniques and approaches for pianists encountering new works. The toolbox, I argue, is also valuable when applied to older music and to how we approach any musical situation on a general level.
The otherness of the self - how to curate a seventeenth century opera and sing all the roles yourself
Authors: Elisabeth Holmertz  , Elisabeth Laasonen Belgrano  , Jonas Howden Sjøvaag
Published: April 2021

The Otherness of the Self
- how to curate a Seventeenth century Opera and sing all the Roles yourself. (or: -how to connect and disconnect the roles of the Baroque soprano and her postmodern Otherness. ) (or - a Voce sola in dialogo)

-Is it possible to perform an opera and sing all the roles yourself? Is it even possible that we’ll come closer to the core in the music and the narrative if everything is anchored in one single person?
-Can I use the interpretation of opera characters to better understand my different roles as a musician - the baroque soprano and the new music singer?
- Am I two (or three, or fifty) different singers/musicians/roles depending on what genre or style I’m performing? What divides them? What ties them together? What factors determine how the voice will work, or not?
- What can I use from my knowledge of early music in my practice as a performer of contemporary music, and vice versa?
Interimp
Authors: Lisa Dillan
Published: April 2021

Denne nettsiden dokumenterer refleksjonsarbeid fra det kunstneriske utviklingsprosjektet Improvisasjon som møtepunkt i en intermedial kontekst (INTERIMP) – et samarbeidsprosjekt mellom Norges musikkhøgskole (NMH) og Balletthøgskolen ved Kunsthøgskolen i Oslo (KHiO), med ekstern finansiering fra det nasjonale Program for kunstnerisk utviklingsarbeid/Prosjektprogrammet (2012–2015).

Prosjektdeltakere har vært musikerne Lisa Dillan, Sidsel Endresen (2012–2014) og Ivar Grydeland (alle NMH), og danserne Siri Jøntvedt, Cecilie Lindeman Steen og Ingunn Rimestad (alle KHiO).

Formålet med prosjektet har vært å undersøke og øke bevisstheten rundt prosesser og problemstillinger som oppstår når improviserende dansere og musikere møtes på gulvet.

Aktiviteten i prosjektet har bestått av arbeid på gulvet og arbeid på møterommet, og det har vært en gjensidig og kontinuerlig veksling mellom disse fasene. Utprøvinger og tester på gulvet har informert diskusjonene på møterommet, som igjen har generert nye utprøvinger og tester på gulvet.
Performing Hanne Darboven's Opus 17a and long duration minimalist music
Authors: Michael Duch
Published: April 2021

Hanne Darboven’s (1941-2009) Opus 17a is a composition for solo double bass that is rarely performed due to the physical and mental challenges involved in its performance. It is one of four opuses from the composers monumental 1008 page Wünschkonzert (1984), and was composed during her period of making “mathematical music” based on mathematical systems where numbers were assigned to certain notes and translated to musical scores. It can be described as large-scale minimalism and it is highly repetitive, but even though the same notes and intervals keep repeating, the patterns slightly change throughout the piece.

This is an attempt to unfold the many challenges of both interpreting, preparing and performing this 70 minute long solo piece for double bass consisting of a continuous stream of eight notes. It is largely based on my own experiences of preparing, rehearsing and performing Opus 17a, but also on interviews I have conducted with fellow bass players Robert Black and Tom Peters, who have both made recordings of this piece as well as having performed it live. One is met with few instrumental technical challenges such as fingering, string crossing and bowing when performing Opus 17a, but because of its long duration what one normally would take for granted could possibly prove to be challenging.
Artistic Research as a Process of Unfolding
Authors: Darla Crispin
Published: April 2021

As artistic research work in various disciplines and national contexts continues to develop, the diversity of approaches to the field becomes ever more apparent. This is to be welcomed, because it keeps alive ideas of plurality and complexity at a particular time in history when the gross oversimplifications and obfuscations of political discourses are compromising the nature of language itself, leading to what several commentators have already called ‘a post-truth’ world. In this brutal environment where ‘information’ is uncoupled from reality and validated only by how loudly and often it is voiced, the artist researcher has a responsibility that goes beyond the confines of our discipline to articulate the truth-content of his or her artistic practice. To do this, they must embrace daring and risk-taking, finding ways of communicating that flow against the current norms.

In artistic research, the empathic communication of information and experience – and not merely the ‘verbally empathic’ – is a sign of research transferability, a marker for research content. But this, in some circles, is still a heretical point of view. Research, in its more traditional manifestations mistrusts empathy and individually-incarnated human experience; the researcher, although a sentient being in the world, is expected to behave dispassionately in their professional discourse, and with a distrust for insights that come primarily from instinct. For the construction of empathic systems in which to study and research, our structures still need to change. So, we need to work toward a new world (one that is still not our idea), a world that is symptomatic of what we might like artistic research to be.

Risk is one of the elements that helps us to make the conceptual twist that turns subjective, reflexive experience into transpersonal, empathic communication and/or scientifically-viable modes of exchange. It gives us something to work with in engaging with debates because it means that something is at stake.

To propose a space where such risks may be taken, I shall revisit Gillian Rose’s metaphor of ‘the fold’ that I analysed in the first Symposium presented by the Arne Nordheim Centre for Artistic Research (NordART) at the Norwegian Academy of Music in November 2015. I shall deepen the exploration of the process of ‘unfolding’, elaborating on my belief in its appropriateness for artistic research work; I shall further suggest that Rose’s metaphor provides a way to bridge some of the gaps of understanding that have already developed between those undertaking artistic research and those working in the more established music disciplines.
Percussion Theatre: a body in between
Authors: Jennifer Torrence
Published: April 2021

What does the musician become when sound and instrumental thinking are no longer privileged as the foundation of a musician's practice? In what ways does an emphasis on the musician's body cause music to approach art forms such as theatre and performance? After a generation of pioneering work from Mauricio Kagel, Dieter Schnebel, John Cage and many others, where is the theatrical and the performative in music today? How do its recent developments shape, alter, constitute a musician's artistic practice? Through her research, Jennifer Torrence argues that this type of music demands the musician assume a different understanding and relation to their instrument and therefore a different relation to their body. This relation calls for new ways of making and doing (new artistic practices) that foreground the body as a fundamental performance material. Through an emphasis on the body, the musician emerges as a performer.

This exposition is a reflection on the research project Percussion Theatre: a body in between. This project is comprised of a collection of new evening-length works that approach the theatrical and performative in contemporary music performance. These works are created with and by composers Wojtek Blecharz, Carolyn Chen, Neo Hülcker, Johan Jutterström, Trond Reinholdtsen, François Sarhan, and Peter Swendsen. The exposition contains reflections on recent developments in contemporary music that mark a mutation of the executing musician into a co-creating performer, as well as images, artefacts, videos, and texts that unfold the process of creating and performing the work that constitutes this project. The ambition of this exposition is that through the exposure of a personal artistic practice an image of a larger field may come into focus.
Site Awareness in Music – recontextualizing a sensation of another place
Authors: Knut Olaf Sunde
Published: April 2021

The project argues that a sensation of another place is vital to the recognition of unfamiliar perspectives.
Space and sound are inextricably connected. The surroundings and context are central to how we perceive external stimuli, such as images, events, history, ideas or music. The brain interprets and make choices by association, based on what the body perceives and based on previous knowledge and experience. How humans listen, hear, see, perceive, interpret and react to our surroundings are based on our cognitive structures.

An unformatting of society is needed.

A risk makes the body and brain aware and alert. Adrenalin is released to the blood, enabling the organism to sudden and severe effort. Risk implies something unestablished, uncertain, a danger, something unknown. Risk implies the possibility of failure and ultimately death. Risk increase anxiety and excitement, enabling the alertness needed to maneuver away from or solve problems. When something is at stake, interest is set into play. The unknown is by its very nature beyond the body’s experience.

The project is about increasing the awareness of the situational and contextual implications of music. This is enquired through three works. For each site or situation I work with, I analyze its characteristics, such as acoustical conditions, the relations of the place to its surroundings, the shape of the landscape and historical or political context.
I try to create immersive, audiovisual projects that are connected to a certain place.
I aim to involve qualities and characteristics from the place, shaping a conversation, putting something at stake.
I conceive a music activating the place, making created situations.
I do this because there is a close link between memory, comprehension and place.

The sense of place and ability to navigate is essential to our memory and bodily existence in the world.

Main supervisor: Ole Lützow-Holm
Second supervisor: Marianne Heier
Creating with timbre
Authors: Magda Mayas
Published: April 2021

Unfolding processes of timbre and memory in improvisational piano performance

This exposition is an introduction to my research and practice as a pianist, in which I unfold processes of timbre and memory in improvised music from a performer’s perspective.
Timbre is often understood as a purely sonic perceptual phenomenon. However, this is not in accordance with a site-specific improvisational practice with changing spatial circumstances impacting the listening experience, nor does it take into account the agency of the instrument and objects used or the performer’s movements and gestures.

In my practice, I have found a concept as part of the creating process in improvised music which has compelling potential: Timbre orchestration. My research takes the many and complex aspects of a performance environment into account and offers an extended understanding of timbre, which embraces spatial, material and bodily aspects of sound in improvised music performance.

The investigative projects described in this exposition offer a methodology to explore timbral improvisational processes integrated into my practice, which is further extended through collaborations with sound engineers, an instrument builder and a choreographer:

-experiments in amplification and recording, resulting in Memory piece, a series of works for amplified piano and multichannel playback
- Piano mapping, a performance approach, with a custom-built device for live spatialization as means to expand and deepen spatio-timbral relationships;
- Accretion, a project with choreographer Toby Kassell for three grand pianos and a pianist, where gestural approaches are used to activate and compose timbre in space.

Together, the projects explore memory as a structural, reflective and performative tool and the creation of performing and listening modes as integrated parts of timbre orchestration. Orchestration and choreography of timbre turn into an open and hybrid compositional approach, which can be applied to various contexts, engaging with dynamic relationships and re-configuring them.
Anesthetic management of a patient with Freeman-Sheldon syndrome undergoing oral surgery: A case report
Authors: (Boku) Aiji Sato , Sento Yoshiki , Hasegawa Tatsuya , Tsutsumi Kosuke , Kamimura Yuji , So MinHye , Kako Eisuke , Sobue Kazuya
Published: April 2021

Freeman-Sheldon syndrome (FSS) is characterized by multiple joint
contractures, characteristic facial features, such as microtia, defects
of the hands and feet, such as clubfoot, and skeletal malformations.
This report illustrates the case of a patient with FSS who was managed
under local anesthesia with intravenous sedation for oral surgery.
Analysis of digitalization referred to in strategic policy documents in the lifelong education context
Authors:   Latvia University of Life Sciences and Technologies, Pelse Modrite , Lescevica Maira ,   Vidzeme University of Applied Sciences
Published: April 2021

Previous research studies on digitalization as an important driver of development has been largely discussed in the context of entrepreneurship, determining its effects on economic growth. Over the past decade, the role of digitalization in public administration – in providing quality and user-friendly services – has been stressed, with less emphasis being placed on its importance in strategic planning. The driving force of change is digital transformation, which requires digital skills and knowledge. The digital literacy of European Union residents has improved, yet in seven EU Member States it was rated as low or very low. Lifelong education helps to deal with this problem, and it has become a necessity for the entire society. The aim of the present research is to determine the role of digitalization in strategic policy documents in the context of lifelong education. The paper analysed the National Development Plan of Latvia 2021-2027 (final version), the Digital Agenda 2020 for Estonia and the Progress Strategy “Lithuania 2030”. The mentioned strategic documents have set a number of goals and objectives directly relating to the implementation of digitalization in order to facilitate the work of society, enterprises and public administration. The policy documents refer to digitalization in lifelong education as mostly a communication and information tool requiring adequate digital skills to be provided by educational institutions. The research employed the monographic, content analysis and descriptive methods. The strategic policy documents of Latvia have been compared with the corresponding documents of the other Baltic States, as the historical and economic development of the countries has followed a relatively similar scenario, and all the Baltic States are EU Member States.
The Rapid Transition to Telemedicine and Its Effect on Access to Care for Patients With Type 1 Diabetes During the COVID-19 Pandemic
Authors: Tilden Daniel R. , Datye Karishma A. , Moore Daniel J. , French Benjamin , Jaser Sarah S.
Published: April 2021

OBJECTIVE

We compared the uptake of telemedicine for diabetes care across multiple demographic groups during the coronavirus disease 2019 pandemic to understand the impact of telemedicine adoption on access to care.

RESEARCH DESIGN AND METHODS

The study analyzed demographic information of patients with type 1 diabetes seen between 1 January 2018 and 30 June 2020 at a single center. We compared the odds of completing a visit via telemedicine across multiple demographic characteristics.

RESULTS

Among 28,977 patient visits, the odds of completing a visit via telemedicine were lower among non-English-speaking (1.7% vs. 2.7%; adjusted odds ratio [aOR] 0.45, 95% CI 0.26–0.79) and Medicaid-insured (32.0% vs. 35.9%; aOR 0.83, 95% CI 0.72–0.95) pediatric patients. No clinically significant differences were observed for other demographic factors.

CONCLUSIONS

Rapid transition to telemedicine did not significantly impact access to diabetes care for most demographic groups. However, disparities in access to care for historically marginalized groups merit close attention to ensure that use of telemedicine does not exacerbate these inequities.
Absenteeism as a mechanism of repression of demand in the Brazilian public sector: accounting reflex in federal education public institutions
Authors: Mendes Nara Cristina Ferreira , Serrano André Luiz Marques , Ferreira Lucas Oliveira Gomes , Meneses Pedro Paulo Murce
Published: April 2021

Absenteeism is seen as a critical problem in public organizations, since the factors that generate it negatively impact the productivity of organizations. In this sense, considering that Federal Institutions of Higher Education represent almost half of the entire workforce existing in the Federal Executive Branch, this article aims to identify absenteeism, as well as its typification, in addition to measuring its accounting reflex. The methodology adopted was panel data analysis, through the analysis of the absenteeism index with time series from 2008 to 2018. The research findings reinforce that absenteeism is more representative when it is due to a stricto sensu graduate program and medical licenses. Furthermore, it was found that the absenteeism rate doubles every 5 years.
Acute Bowel Obturation: Treatment Outcomes
Authors: Charyshkin A. L. , Keshyan E. A.
Published: April 2021

Background. Two-stage colostomy is a common choice in treatment for obstruction-complicated colorectal cancer.

Aim. Research into paracolostomy complications in obese and non-obese patients.

Materials and methods. Material on obstruction-complicated colorectal cancer was collected from 50 patients divided into two cohorts by the body mass index (BMI). Cohort 1 contained 25 patients with BMI <24, and cohort 2 — patients with BMI >30.

Results. Compared to cohort 1 with BMI <24, obese cohort 2 revealed more paracolostomy complications, the increase in parastomal skin lesions by 32% (p < 0.05), pyoinflammatory complications by 36% (p < 0.05) and abscesses by 24% (p < 0.05).

Discussion. Paracolostomy complications in patients with BMI >30 are due to obesity, a poorly fitting colostomy bag, faecal leakage, skin irritation, infection and crude coagulation in haemostasis. Stoma gradually becomes difficult to visualise, faecal leakage continues and the paracolostomy space is poorly drained in obese patients, contributing to pyoinflammatory parastomal complications.

Conclusion. The main causes of pyoinflammatory parastomal complications in obese patients are a low stoma positioning and poor paracolostomy drainage. The circumstances described warrant improvement of colostomy techniques in obese patients.
A Tool for Thyroid and Breast Punch Biopsy
Authors: Sigal Z. M. , Surnina O. V.
Published: April 2021

Background. Diagnosis of thyroid and mammary gland neoplasms is a persisting challenge. The common punch biopsy techniques exhibit significant drawbacks responsible for biasing the gland tumour inspection. The authors propose technical and methodological novelties in punch biopsy for improving the sensitivity and accuracy of neoplasm differential diagnosis in surgery.

Materials and methods. A control cohort of 1406 patients had a conventional punch biopsy without ultrasonic guidance, whereas the study cohort of 1870 patients had puncturing with a novel device suitable for voluminous thyroid and mammary gland neoplasm biopsy.

Results. A novel punch biopsy method is developed basing on the oscillation amplitude and tissue optical density determination. The novel puncture appliance and technique allowed an accuracy improvement of voluminous thyroid and mammary gland neoplasm puncture up to 90 %. No complications of thyroid neoplasm punch biopsy were observed in the study cohort. The control group exhibited the complications of impaired swallowing, local inflammation and haematomas at the puncture site.

Discussion. The punch biopsy technique based on the pulse oscillation amplitude and optical tissue density measurement was proved to allow an earlier detection of voluminous neoplasms compared to visual inspection, while an additional canal allows concurrent biopsy of the lesion-adjacent tissue and the assessment of therapeutic efficacy and disease progression.

Conclusion. Creative surgical approaches to punch biopsy based on emitter and optic sensor-geared pulse optometry and their implementing tool have been developed. The method improves the efficiency and accuracy of voluminous neoplasm differential diagnosis, provides control of treatment efficacy and prevents false positive and false negative detections.
Modified Porro’s Operation in Ovarian Cancer: a Clinical Case
Authors: Yashchuk A. G. , Fatkullina I. B. , Rahmatullina I. R. , Musin I. I. , Molokanova A. R.
Published: April 2021

Background. Ovarian cancer in pregnancy is quite rare having a top 5th incidence among other pregnancy-associated tumours [1]. Due to a low population rate in pregnant women, the lack of standardised management of such patients and the paucity of relevant randomised and cohort studies, analyses of individual clinical cases acquire particular importance.

Materials and methods. This article presents a clinical case of de novo diagnosed ovarian cancer in pregnancy tackled with a modified Porro’s operation of peritonectomy, para-aortic and parametric lymphadenectomy and greater omentum resection at a gynaecology unit of the Kuvatov Republican Clinical Hospital of Ufa.

Results and discussion. This clinical case is special in terms of a rare occurrence of ovarian cancer in pregnancy. The choice of this radical surgical technique is considered optimal for inspecting most plausible metastatic foci and ensuring a life-preserving prognosis.

Conclusion. In the absence of standardised management protocols in pregnancy-associated ovarian cancer, further analyses and discussions of routine clinical case evidence are imperative.
Modern Techniques for Cervical Cancer Radiotherapy
Authors: Lushnikova P. A. , Sukhikh E. S. , Izhevsky P. V. , Sutygina Ya. N. , Tatarchenko M. A. , Pyzhova I. B.
Published: April 2021

Cervical cancer is a socially significant illness often impacting women of reproductive and working age. The patients’ young age and social activity warrant the development of effective and safe therapies.

The past decades have witnessed the novel radiation techniques to contain cervical cancer: 3DCRT-3D, IMRT, and VMAT, adaptive radiotherapy, CT/MRI-guided intracavitary radiation, combined interstitial and intracavitary radiation, abandoning intracavitary intervention for external beam delivery with sequential or concurrent cervical dose escalation, under brachytherapy unfeasible.

Modern equipment and treatment planning systems allow a high dose delivery to the tumour and intracavitary treatment with visual control of the target and organs at risk. Combining of intracavitary and interstitial radiotherapy enables a better dose coverage of the target at a minimal radiation impact on organs at risk.

Phasing-out of intracavitary for external radiotherapy may enable a cancericide dose delivery to the tumour under intractable intracavitary treatment.

The major goal of technic novelties is the establishment of personalised radiotherapy for improving treatment outcomes and reducing the incidence and/or severity of radiation side effects. The article overviews the radiotherapy techniques for cervical cancer treatment and routes of their development.
Antitumour Activity of Dehydroxymethylepoxyquinomycin (DHMEQ): a Literature Review
Authors: Umezawa K. , Gantsev Sh. Kh. , Kzyrgalin Sh. R. , Yamidanov R. S. , Amirov R. A. , Zhuk E. I.
Published: April 2021

Carcinogenesis research uncovers new pathogenesis links as vulnerable targets of effective antitumour therapies. Among the key mediators of immune response, cell proliferation, cell apoptosis and inflammation is transcription factor NF-κB. Misregulation of an NF-κB-dependent pathway is found in solid and haematopoietic tumour cells. One of the best known NF-κB functions is expression regulation of genes involved in the apoptosis inhibition or activation and survival in both intact and malignant cells. The NF-κB-mediated pathways’ involvement in carcinogenesis, angiogenesis and tumour resistance to chemo- and radiotherapies makes this factor a promising target for drug anti-cancer interventions. This review summarises evidence on the antitumour and anti-inflammatory activity of a high-potent and specific low molecular-weight NF-κB inhibitor, dehydroxymethylhepoxyquinomycin (DHMEQ), as a candidate therapeutic agent in treatment for variant malignancies.
Confocal Laser Scanning Microscopy in Cancer Diagnosis: Current Issues and Application Outlook
Authors: Khismatullina Z. R. , Chebotarev V. V. , Zakirova Yu. A. , Jashkina A. A.
Published: April 2021

The review highlights the power and prospects of confocal laser scanning microscopy in cutaneous cancer diagnosis. This non-invasive technology allows optical skin sectioning at a varying depth with no special tissue treatment or staining. This diagnostic method is currently considered the most promising in imaging and assessment of superficial skin neoplasms. It enables a deeper investigation of skin structures at higher beam powers, which, however, implies possible skin damage. Recent technological advances in the field facilitated the development of new, portable, more practical personal confocal laser scanning microscopy devices providing for an efficient and deeper imaging of skin lesions less accessible otherwise. The technology enables a multiple repeated visualisation of the same skin spot at different time intervals for monitoring the neoplasm progression, therapy impact and cancer dynamics in skin. Numerous studies have determined the basic confocal properties of various tumoural lesions and showed a good correlation with dermatoscopy and histology data. This diagnostic technique allows a multiple non-damaging examination of same skin area, as well as the monitoring of tumourigenesis, clinical dynamics and treatment outcome.
Risk factors and AGTR1 gene polymorphism (1166A>C) in patients with essential hypertension
Authors: Semianiv M.
Published: April 2021

Objective – to analyze the association of risk factors with the 1666 A>C polymorphism of the AGTR1 gene in patients with essential hypertension.Material and methods. 100 patients were screened, 72 of whom were genotyped. The control group consisted of 48 healthy individuals who did not differ in gender and age, and with the group of patients.Results. The obtained data confirmed that the level of blood pressure elevation is associated, to some extent, with modified (diabetes mellitus 2, smoking, body mass index) and unmodified factors (family history, gender) the risk of essential hypertension. The results of the analysis of blood pressure levels considering the A1166C polymorphism of the AGTR1 gene showed that the values of systolic and diastolic blood pressure in the group of patients with C-allele carriers were higher than in carriers of AA genotype: SBP – by 5.38% (p<0.05), DBP – by 5.15% (p<0.05). Conclusions. The level of blood pressure in patients with essential hypertension depends on body mass index and smoking. In carriers of the C-allele of the AGTR1 gene (A1166C), the level of systolic and diastolic blood pressure exceeds the ones of the carriers of the AA genotype. The presence of the C-allele of the AGTR1 gene (A1166C) almost doubles the risk of severe essential hypertension [OR = 2.75; p = 0.037].
Association between gene polymorphism of the tissue inhibitor matrix metalloproteinase-2 (G303→A) and enterocutaneous fistula
Authors: Voitiv Ya. , Usenko O.
Published: April 2021

Objective – to analyze the frequency of polymorphic variants of tissue inhibitors of metalloproteinase-2 (G303→A) gene in patients with enterocutaneous fistula. Material and methods. The object of the study comprises 19 patients with enterocutaneous fistula who were treated in the Shalimov National Institute of Surgery and Transplantology during 2016-2019. Laboratory, genetic, histological studies and statistical analysis were performed.Results. As a result of genetic and statistical analysis of the tissue inhibitors of metalloproteinase-2 (G303→A) gene single nucleotide polymorphisms, genotype variants have been identified that are associated with the risk of enterocutaneous fistula development. All models of inheritance were analyzed and the best model with the lowest Akaike information criterion, which turned out to be a recessive model, has been determined.Conclusions. Enterocutaneous fistula is 1,58 times more common in carriers of homozygous GG genotype of the tissue inhibitors of metalloproteinase-2 (G303→A) gene and twice less common in heterozygotes GA (21,1% vs. 40%, p=0,057). Carriers of minor homozygotes of AA genotype in the group with enterocutaneous fistula were not detected, while a similar genotype in the control group was found in 10% of cases.
Ser una wianbu en la Corea del Sur de la posguerra
Authors: Park Morgan Mok-won
Published: April 2021

El artículo compara dos textos que ofrecen distintas perspectivas sobre una misma situación de opresión ejercida sobre las mujeres desde el poder. En primer lugar, examina un informe emitido por la policía del distrito de Yongsan de Seúl en 1971. Se trata de unas directrices que, con un lenguaje retórico, pretendían condonar los crímenes que los soldados americanos cometían contra las prostitutas al mismo tiempo que trataban de imponer a la población coreana una actitud benévola hacia aquéllos. Paralelamente, el artículo analiza la novela Chinatown, escrita por Oh Jung-hee en 1979, en la que se muestra una visión de los acontecimientos de la época desde la perspectiva de los habitantes locales. En contraposición al texto anterior, en esta obra se refleja la creciente escalada de violencia que las prostitutas sufrieron a manos de los militares americanos. Con base en el análisis crítico del discurso, cotejo estos dos textos para revelar cómo determinados mecanismos lingüísticos contribuyen a la transmisión de una ideología patriarcal e imperialista.
La casuística homoerótica a través de la antología poética de al-Minhāŷī: imberbes y barbipungentes
Authors: Lucena Romero Miguel Ángel
Published: April 2021

El objetivo del presente artículo es analizar la casuística homoerótica y pederasta en el islam clásico, a través de la antología poética Basṭ al-a‘ḏār ‘an ḥubb al-‘iḏār [Exposición de los pretextos sobre el amor de los aladares] del jatib al-Minhāŷī (m. 1585). Se parte de una introducción al concepto de homoerotismo en la legalidad islámica y se presentan los factores principales acuñados por los poetas árabes sobre esa pasión platónica-homosexual por muchachos adolescentes, imberbes y barbipungentes.
“El alma de las flores”. La compasión del Buda Gotama en la poesía de Kaneko Misuzu
Authors: Villamor Herrero Efraín
Published: April 2021

La poesía infantil de Kaneko Misuzu es una de las más populares de la literatura moderna japonesa. Destaca por describir el mundo con una sensibilidad especial, avivada, según muchos estudios previos, por la influencia de las enseñanzas de la escuela Jōdoshinshū, a la cual Misuzu tuvo acceso desde muy temprana edad. Sin embargo, ciertas reflexiones en su poesía hablan de la benevolencia con las plantas y otros objetos inanimados, pensamientos similares a las enseñanzas del Buda Gotama. El presente trabajo analiza estas semejanzas en algunos de sus poemas y se centra en el concepto de compasión que Misuzu profesa a las plantas y otros objetos inertes en el contexto filosófico budista.
Uso y abuso del término ὄχλος en Tucídides
Authors: Donoso Johnson Paulo
Published: April 2021

En griego antiguo existen al menos cinco términos que definen la masa, la muchedumbre y la multitud. Uno de ellos es ὄχλος, concepto nacido en el siglo V a.C. el cual es utilizado de manera reiterativa por Tucídides como un tendencioso sinónimo de δῆμος. A partir del análisis de algunas de las dieciocho menciones al término ὄχλος en su obra, es posible reafirmar el poderoso efecto político de este concepto con el fin de demostrar, una vez más, el fuerte componente antidemocrático en su obra.
Sobre la presencia de Orobanche hederae Vaucher ex Duby en el Parque Nacional Marítimo-Terrestre de las Islas Atlánticas (Galicia, España)
Authors: Camaño Portela José Luís , Pino P´érez Juan José , Silva-Pando Francisco Javier , Pino Pérez Rubén
Published: April 2021

Durante la campaña de herborización de 2019, realizada en el territorio del Parque Nacional de las Islas Atlánticas (Pontevedra, España) con el objetivo de mejorar el conocimiento de su flora, se encontró una población estable de Orobanche hederae Vaucher ex Duby. El hallazgo supone una interesante novedad para el catálogo del Parque y una ampliación muy notable de su presencia en Galicia.
Datos sobre las comunidades ibéricas de Pinguiculion longifoliae F. Casas 1970 (Cl. Adiantetea capilli-veneris Br.-Bl. in Br.-Bl., Roussine & Nègre 1952)
Authors: Crespo Villalba Manuel B. , Alonso Vargas Mª Ángeles , Martínez Azorín Mario
Published: April 2021

Se presentan nuevos datos sobre las comunidades rupícolas de la alianza Pinguiculion longifoliae en la Península Ibérica. Estos tipos de vegetación crecen en roquedos calcáreos y dolomíticos, particularmente en paredones y abrigos umbrosos, sobre suelos apenas desarrollados donde se forman tobas que permanecen húmedas y rezumantes durante gran parte del año, debido al afloramiento continuo de agua. Aunque hasta el momento se venía aceptando la existencia de cinco asociaciones en la Península Ibérica, estudios recientes sobre la taxonomía de las especies rupícolas de Pinguicula en el este y sur peninsulares permite una nueva interpretación de estos frágiles hábitats. En la presente aportación se reconocen ocho asociaciones en la alianza, de las que una se describe como nueva (Eucladio verticillati-Pinguiculetum casperianae ass. nov.); se realiza una nueva combinación nomenclatural en el rango de asociación (Adianto capilli-veneris-Pinguiculetum dertosensis comb. nov.); y se corrige el nombre de otra asociación (Southbyo tophaceae-Pinguiculetum tejedensis nom. corr.). Para todas ellas se ofrecen datos sobre su sinonimia, composición florística habitual, ecología y corología, y se indica también su tipo nomenclatural (incluyendo la designación de un lectótipo para la Adianto-Pinguiculetum dertosensis).
Acerca de unas presuntas novedades taxonómicas y corológicas de gramíneas para Extremadura (España)
Authors: Romero-Zarco Carlos Manuel
Published: April 2021

Se discuten ciertos datos taxonómicos y corológicos de nueve taxones de gramíneas (Poaceae) de los géneros Anthoxanthum, Arrhenatherum, Avena y Helictochloa publicados recientemente en relación con la flora de Extremadura (España).
Víctimas de delincuencia en Málaga
Authors: Díez Ripollés José Luis
Published: April 2021

La sección de Málaga del Instituto Andaluz Interuniversitario de Criminología inicia con este ejemplar la publicación de un boletín criminológio. A través de él, y en una periodicidad mensual, se pretende hacer llegar a los grupos de investigación, instituciones públicas y privadas, y medios de comunicación social interesados información rápida, sencilla y breve sobre datos relativos a la criminalidad obtenidos por las investigaciones en curso del Instituto.

Sin que en ningún momento se quiera sustituir la publicación completa y plenamente acorde con los parámetros académicos y científicos de la correspondiente investigación y sus resultados, este Boletín aspira a satisfacer necesidades más inmediatas, tanto de investigadores deseosos de conocer los datos ya disponibles sobre estudios conectados a sus áreas de interés, como de instituciones y medios de comunicación directamente preocupados por la evolución de las realidades sociales ligadas a la criminalidad.

Esperamos con ello aumentar la difusión del conocimiento sobre la delincuencia en Andalucía, y facilitar así los esfuerzos para su comprensión y confrontación.
La legalización de la Eutanasia: Seminario sobre su tratamiento Jurídico
Authors: Del Rosal  , Stangeland  , Escohotado  , Seminara  , Koch  , V. Kalmthout  , Gonzálvez  , Queloz  , Nakayama  , Kuzuhara  , Kelly  , Winslade  , Cairoli  , Keyserlingk
Published: April 2021

La Sección de Málaga del Instituto Andaluz Interuniversitario de Criminología celebró los días 3 a 5 de Noviembre un Seminario jurídico internacional sobre Eutanasia. A tal efecto representantes de España (Del Rosal, Stangeland, Escohotado), Italia (Seminara), Alemania (Koch), Holanda (v. Kalmthout), Francia (Gonzálvez), Suiza (Queloz), Japón (Nakayama/Kuzuhara), Australia (Kelly), Estados Unidos (Winslade), Uruguay (Cairoli) y Canadá (Keyserlingk) presentaron ponencias donde, tras recoger un conjunto de datos criminológicos, analizaron la situación legal y las propuestas de reforma de sus respectivos países en relación con las variadas situaciones en las que se plantea la problemática de la eutanasia. El Seminario, que contó igualmente con la presencia de los profesores españoles Mu-oz Conde, Carbonell Mateu, Valle Muñiz, Mapelli Caffarena, así como de una buena parte de los profesores integrantes de la Sección de Málaga del I.A.I.C, dedicó una parte importante de su tiempo al desarrollo de intensos debates entre el restringido número de participantes. Lo que aquí sigue es un brevísimo resumen de lo que sucedió, estando prevista la publicación de un volumen con todas las ponencias, así como con una relación general de los debates que llevarán a cabo los profesores Muñoz Sánchez y Prieto del Pino.
Llamadas de urgencia a la policía local
Authors: Carbonero Torres Rafael , Cea Espinosa Antonio , Guerrero Checa Antonio , Piña Carranza Francisco
Published: April 2021

En España existen cuatro Cuerpos de policía: Guardia Civil, Policía Nacional, Policía Autonómica y Policía Local. Cada uno de ellos tiene sus tradiciones, sus razones de ser y su campo de actuación delimitado en leyes y reglamentos. Sin embargo, el público puede quedarse confuso ante tantos uniformes distintos y quizás darse cuenta de que, cuando le hace falta la asistencia policial, no aparecen ninguno de los cuatro. En la guía telefónica existen tres números para llamadas urgentes a la policía: 091 para la Policía Nacional, 092 para la Policía Local y 062 para la Guardia Civil. Es probable que muchos de los ciudadanos que marcan uno de estos números no sepan a quién corresponde ayudarle en su problema y que las actuaciones de los distintos Cuerpos con mucha frecuencia se solapen.

Este trabajo analiza las llamadas realizadas por parte de los ciudadanos de Málaga al teléfono de urgencias de la Policía Local. Este teléfono, el más usado de los tres, recibe cerca de cien mil llamadas al año, de las cuales en este boletín se analizan más detalladamente las llamadas de una semana. En números futuros esperamos poder presentar material sobre la actuación de los demás Cuerpos de policía y así analizar el perfil de trabajo de cada uno.
Prevención de la delincuencia en el casco urbano y en zonas turísticas
Authors: Stangeland Per , Felson Marcus
Published: April 2021

Una pregunta que nos han hecho de forma más o menos directa muchos abogados, policías y jueces sobre este boletín es la siguiente: «¿Para qué sirven tantas encuestas y estadísticas sobre los delitos?» La respuesta concisa es: «Para poder prevenirlos.» Sin un amplio bagaje de conocimientos sobre las diversas formas de delincuencia y un análisis objetivo sobre el funcionamiento de la policía y los juzgados, difícilmente se pueden desarrollar propuestas sobre mejoras en la respuesta social ante el delito, ni tampoco poner en marcha programas para la prevención de la delincuencia. Sin embargo, un instituto universitario no tiene los recursos económicos ni personales para organizar iniciativas de este tipo. Nuestro papel ha de estar limitado, por tanto, a la presentación de propuestas, mientras a otros órganos les corresponde tomar decisiones sobre su desarrollo. Si las sugerencias presentadas resultan viables y despiertan interés, el IAIC, sección de Málaga, está en condiciones de desarrollar y coordinar la puesta en práctica de los proyectos, así como de realizar el seguimiento y evaluación de los mismos.
Violadores y agresores sexuales
Authors: Bueno García Mª José , Sánchez Rodríguez Luis M.
Published: April 2021

Los datos que se exponen en este boletín forman parte de dos trabajos de investigación más amplios, de los cuales uno ha sido presentado como tesis doctoral en la cátedra de Medicina Legal de la Universidad de Málaga. El objetivo de este último fue contrastar la personalidad, actitudes y experiencias sexuales de delincuentes sexuales violentos con los de un grupo control formado por delincuentes no sexuales. El segundo trabajo, aún en fase de realización, trata de establecer parámetros discriminadores entre los delincuentes sexuales en función de la edad de sus víctimas.

Las conclusiones mostradas corresponden a un apartado común a ambos estudios, en el cual se describe, por una parte, el perfil del delincuente sexual violento (entendiendo por tal al autor de conductas tipificadas en el Código Penal como «violación» y «agresiones sexuales») y las circunstancias presentes en la ejecución de estos delitos y, por otra, se analizan algunas características de las víctimas.