bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative analysis of prostatoliths and corpora amylacea effects on the immunophenotype of prostate cancer
Authors: Piddubnyi A.M.
Published: July 2019

Prostate cancer (PC) has the highest incidence rate in a male population all over the world. The aim of the work was to compare the effect of prostatic calculi and corpora amylacea on the immunophenotype of PC. 10 samples of PC with calculi, 20 samples with a corpora amylacea and 30 control samples were used for this study. Histochemical techniques (alizarin red, von Kossa, Congo red stainings), scanning electron microscopy with energy dispersive X-ray spectroscopy and immunohistochemistry (antibodies against AR, p53, Casp3, Bax, MMP1, HSP70, Hsp90, VEGF, CD68 and MPO) were used. Statistical processing was carried out by the Shapiro-Wilk test, Mann-Whitney U-test and Student t-test. The presence of intraluminal inclusions is accompanied by increased expression of proapoptotic markers Casp3 and Bax by tumor tissue. It was found that in the group of samples with intraluminal inclusions, the expression level of VEGF and Hsp90 is lower in comparison to control group (p<0.05). The difference between VEGF and Hsp90 expression in the PC with calculi and PC with corpora amylacea was not detected (p> 0.05). In the future, it is planned to study the effect of intraluminal inclusions on the development of bone metastasis of PC.
Dynamics of distribution WGA+ receptors in pancreas in norm and after intranatal action of antigens
Authors: Hrinivetska Nataliya , Hryhorieva Olena
Published: July 2019

Study of features of expression of carbohydrate bits (receptors to lectins) on the surface of cells, in the contests of intracellular granules and on components of extracellular matrix allows to widen the understanding of processes of organs morphogenesis and fabrics and understand the features of reactivity in reply to the action of various factors in the antenatal period of development. Research aim — to set the features of distribution and dynamics of expression of receptors to the wheat germ agglutinin (WGA) in the structures of pancreas in a norm and after the intranatal action of antigens. 126 pancreases of white laboratory rats from a moment birth to ninetieth time of postnatal life were examined in the research work. Rats were retained in a vivarium according to corresponding recommendations. The investigated animals were divided into three groups. The first group is intact rats; the second are control rats, the third are rats, what were undergone intranatal injection of Vaxygrip vaccine. During work with experimental animals followed European convention for defense of vertebrates that are used in experimental and other scientific aims (Strasbourg, 18.03.86). Exposure of carbohydrate bits and pieces of N-acetyl-D-glucosamine in microsections was conducted with application of wheat germ agglutinin (WGA), drawing on the standard set of lectins of SEC “Lectintest” (Lviv). Intensity of deposit of benzidine mark was estimated semi-quantitative. It is set that for experimental animals regardless of way of introduction to the antigen is observed increase of closeness of distribution of carbohydrate bits and pieces of N-acetyl-D-glucosamine in all investigated structures, most expressive in the wall of channels and vessels. Fastening of zymogenic granules of pancreatic exocrine cells acinus with bits and pieces of carbohydrate of N-acetyl-D-glucosamine testifies, that converting of proenzyme into an active form takes place at participation of glycopolymers. As carbohydrate determinants enter in the complement of zymogenic granules of pancreatic exocrine cells, the educed increase in an amount receptor to the lectin of embryos of wheat can influence on composition and properties of enzymes that is synthesized in acinar cells.
The dynamics of coagulation hemostasis markers in patients with an increased body mass index with polytrauma
Authors: Kucheriavchenko V.V. , Volkova Yu.V. , Sharlai K.Yu.
Published: July 2019

The hemostasis system is one of the fast response systems of the body. The aim of the work was to analyze the dynamics of coagulation hemostasis markers in patients with an increased body mass index (IBMI) with polytrauma. A study of complex hemostasiograms was conducted in 224 patients with IBMI during a month of hospital stay with a diagnosis of Polytrauma and on the 360th control day of the outpatient visit. The patients were divided into 3 groups depending on the starting numbers of the BMI. The study included the study of activated partial thromboplastin time, prothrombin index, antithrombin III, plasma tolerance to heparin and fibrinogen. To process the data obtained, Student’s t test and correlation analysis were used. The condition of the coagulation situation in patients with IBMI in group I (BMI≤29.9) included a slight increase in the aggregative capacity of platelets without disturbing their number, non-intensive increases in the hemostatic potential in all coagulation tests, dysfibrinogenemia and the absence of disturbances in the system of natural anticoagulants in the early period of traumatic illness. For patients in group II (BMI 30.0–39.9) in the early stages — up to the 14th day — hyperfibrinogenemia was characteristic, with a decrease in fibrinolytic activity. For patients in group III (BMI≥40.0), it was characteristic: in the first week there was dysfibrinogenemia, a sharp — by 50% decrease in antithrombin III, and a decrease in plasma tolerance to heparin. It should be noted that a significant and growing in dynamics reduction in the amount of antithrombin III was less than 80% unfavorable for the progression of coagulation disorders. Thus, it is necessary to note the clinical and pathogenetic significance of hemostasiological disorders in traumatic disease in patients with IBMI with polytrauma, the nature, intensity, dynamics and direction of which determine the consequences and possible complications, and require specific correction. In the future we plan to study the functional state of the system of immunological protection in traumatic disease in patients with IBMI.
Modification of laparoscopic catheter setting for peritoneal dialysis in patients with chronic kidney disease
Authors: Kebkalo A. B. , Reyti A. O. , Gryanila V. V. , Yatsyk I. M.
Published: July 2019

Reducing the complications of the peritoneal dialysis (PD) procedure prolongs its use. The purpose of the work was to justify prolongation of peritoneal dialysis by modifying its setting. The study included 54 patients with chronic renal insufficiency, they carried out laparoscopic setting of PD; 14 patients were with omentopexy and 40 – with a classical statement. The operation was performed under general anesthesia. Surgical tactics were as follows: omentum folds were fixed to the parietal peritoneum; the control catheter was inserted through the window into the mesentery of the colon, and the dialysis portion at the bottom of the pelvis; sutured the window of the mesentery of the colon. Before insertion of the camera port, pneumoperitoneum was induced with a Veress needle, 10 mm below the navel. The pressure of abdominal gas was 12 mm Hg. Art. The point of entry into the abdominal cavity was established by the Hassan method: 5 cm lateral and 7 cm below the navel along the outer edge of the rectus abdominis muscle. A control catheter was inserted into the window under the transverse colon and inflated the balloon, the omentum was fixed to the parietal peritoneum 3 cm above the navel and the window in the colon mesentery was sutured. All early and late postoperative complications of the patients were recorded for 12 months (wound infections, including “tunnel infection”, dialysate leakage past the catheter, obturation of the catheter lumen, loss of tightness of omentoperitoneopexy). The study included 8 men and 6 women, aged from 43 to 76 years, of whom 2 patients had previously been operated on the abdominal organs. The operative intervention time averaged 54,6±15,4 min. No obstruction, catheter migration, or “tunnel infection” was established during the study. We have developed a laparoscopic technique of peritoneopexy of the upper half of the abdominal cavity, which will be used when the resource of the lower half of the abdominal cavity is exhausted and the effectiveness of preventing mechanical complications of the catheter PD has been proven.
O fenômeno do MMA na contemporaneidade: um ensaio sobre a relação entre sua veiculação e o público infanto-juvenil
Authors: Castelo Branco Telles Thabata , Roque Antunes Barreira Cristiano , Ferreira Ângelo Luciana
Published: July 2019

O presente trabalho objetivou analisar o Projeto de Lei 5.534/2009 do deputado federal José Mentor (PT-SP), cuja proposta visava “proibir a transmissão televisiva de toda e qualquer luta marcial violenta”, com destaque para o MMA (sigla em inglês para mixed martial arts) e seu potencial impacto negativo sobre os espectadores infantojuvenis. A presunção desse impacto, questão pertinente à Psicologia do Esporte, é o que se buscou problematizar e discutir, a partir de três eixos principais: um conceitual e histórico, referente ao MMA; um psicossocial, que investiga as percepções e reações sociais ao fenômeno; e um teórico, relativo ao modo como a criança reage à sua inserção cultural e àquilo que a legislação já prevê a fim de garantir seu direito a um contexto de desenvolvimento saudável.
Intervenções físicas e cognitivas combinadas para melhora cognitiva no envelhecimento: uma revisão sistemática
Authors: Sacramento Angela Maria , Soares Chariglione Isabelle Patriciá Freitas
Published: July 2019

O envelhecimento leva a mudanças fisiológicas e funcionais, afetando as habilidades e funcionamento cognitivo dos idosos, que se beneficiam com intervenções combinadas, especialmente com o exercício físico. Esta revisão sistemática realizou a análise de 99 artigos, em espanhol, inglês e português, pelo software IRaMuTeQ, sem demarcação de tempo, utilizando-se da base MEDLINE/PUBMED, e tendo como eixos norteadores as palavras combined intervention, physical exercise, cognition e elderly, sendo elegíveis revisões sistemáticas, meta-análises, estudos experimentais ou teóricos. Foram analisados os resumos dos artigos, e os resultados evidenciaram três grandes categorias de temas (intervenção multimodal, capacidade funcional e fragilidade). Os resultados sugerem que os efeitos da intervenção combinada podem ser mais eficazes à intervenção isolada e os idosos com idade mais avançadas parece que lograram melhores benefícios. Ressalta-se que pesquisa com desenhos mais controlados em estudos brasileiros se fazem necessários para se obter mais informações a respeito do efeito e da eficácia da intervenção combinada física e cognitiva em idosos brasileiros.
KEANEKARAGAMAN FAMILI ARTHROPODA TANAH DI KAWASAN HUTAN PENDIDIKAN WANAGAMA KABUPATEN GUNUNGKIDUL DAERAH ISTIMEWA YOGYAKARTA
Authors: Abdillah Muhammad Muhibbuddin , Handayani Wuri , Prakarsa Tatag Bagus Putra
Published: July 2019

Wanagama Education Forest is the forest made by the ecosystem successions. Wanagama developed on barren hills located at Gunungkidul Province of Yogyakarta Special Region. The succession results providing a new habitat for the wild flora and fauna including soil arthropods. The soil arthropods having an important role in the ecosystem a detritivore etc. This study aimed to knowing soil arthropods diversity at Wanagama. The study conducted at Wanagama Education Forest in December 2017. The soil arthropods collected by six pitch fall trap that was spread at each collection point. Collected specimen by pitch fall trap method then identified and analyzed using diversity, evenness and dominance index. Based on the results, there is 25 family from 13 order of soil arthropods. Based on the data analysis diversity index results are H’=1, 53 and evenness index E=0, 47. The dominant individual is from Formicidae that playing a role as predators at Wanagama. Highest diversity is from Coleoptera order.
LEVEL PEMBERIAN TEPUNG BIJI KARET TERHADAP PRODUKSI DAN BOBOT TELUR BURUNG PUYUH (Coturnix coturnix Japonica)
Authors: Novita Ririn , Herlina Betty , Permata Lepsi
Published: July 2019

The purpose of this study was to determine how the effect of giving rubber seed flour to the production and weight of quail eggs. Includes ration consumption, egg production, egg weight, and feed conversion, which this research was carried out in this research has been carried out Tanjung Sanai II Village, Kec. Ulak Tanding Padang. This research was experimental and carried out using factorial randomized complete variance analysis (RAL) consisting of 6 treatment levels and 4 replications and each treatment consisted of 4 quails. The treatment used is: P0: 100% Commercial ration without rubber seed flour, P1: 94% Commercial ration + 6% rubber seed flour, P2: 91% Commercial ration + 9% rubber seed flour, P3: 88% Commercial ration + 12% rubber seed flour, P4: 85% Commercial ration + 15% rubber seed flour, P5: 82% Commercial ration + 18% rubber seed flour. The results of this study used the rate of addition of rubber seed flour as much as 18% from the ration given, and significantly affected the conversion of rations and did not significantly affect ration consumption, egg production and egg weight.
INVENTARISASI JENIS-JENIS TUMBUHAN FAMILI EUPHORBIACEAE DI KECAMATAN TOPOS KABUPATEN LEBONG PROVINSI BENGKULU
Authors: Yanti Nopa Nopi , Fitriani Linna
Published: July 2019

This study aims to determine the types of plants of the Euphorbiaceae family in Topos District, Lebong Regency, Bengkulu. The research was conducted in May-June 2018 in 7 villages in Topos District, Lebong Regency, Talang Baru 1 Village, Talang Baru 2 Village, Talang Donok 1 Village, Talang Donok 2 Village, Anjay Siang Village, Suka Negri Village, and Villages Bandar Agung. The study was conducted by survey and interview the specimens were taken and analyzed descriptively. From the results of the study founded 20 plant spesies Euphorbiaceae family with 11 genera, namely: Acalypha 1 spesies (Acalypha indica), Aleurites 1 spesies (Aleurites maluccana), Codiaeum 5 spesies (Codiaeum Sp, Codiaeum 'Finger', Codiaeum 'Cronstandt', Codiaeum variegatum 'Norma', Codiaeum variegatum 'Exsotica red'), Euphorbia 4 spesies (Euphorbia hirta, Euphorbia pulcherrima, Euphorbia milli, Euphorbia milli 'Golden eagle'), Excoecaria 1 spesies (Excoecaria chinchinensis), Hevea 1 spesies (Hevea brasilensis), Jartopha 2 spesies (Jatropha curcas, Jatropha gossypiifolia), Manihot 1 spesies (Manihot esculenta), Pedilanthus 1 spesies (Pedilanthus tithymaloides), Phyllanthus 2 spesies (Phyllanthus urinaria, Phyllanthus acidus), Sauropus 1 spesies (Sauropus androguns).
BOXTARIK (BOX PINTAR LISTRIK) INOVASI MEDIA PEMBELAJARAN DENGAN MEMANFAATKAN LIMBAH BOTOL OLI
Authors: Nugroho Toyib Wahyu , Wulandari Nusroh , Budhi Henry Setya
Published: July 2019

One of the most important components in the learning process is learning media. Hamlik (1986) suggests that the use of instructional media in the teaching and learning process can increase new desires and interests, increase motivation and stimulation of learning activities, and even bring psychological effects to students. Utilization of used goods and simple equipment as a medium of learning is not something new in the world of education. As is known, waste is a major problem in Indonesia. Based on data from the Central Bureau of Statistics in 2014 shows that Indonesia produces around 187.2 million tons / year of waste and ranks second as the largest waste producer in the world. Waste does not only come from households but also from the automotive environment, for example used oil bottles. Making learning media from used oil bottles aims to arouse creativity and also instill environmental care, so that they will strive to maintain life for the next, besides that it can also grow the entrepreneurial spirit if it can develop its creativity in making learning media. This study uses an experimental method to obtain appropriate learning media and literature studies from several books, journal articles, and other relevant sources.
EFEKTIVITAS BUKU AJAR BERBASIS HIGHER ORDER THINKING SKILLS (HOTS) PADA MATERI ELASTISITAS DAN HUKUM HOOKE SISWA KELAS XI SMA NEGERI TUGUMULYO TAHUN PELAJARAN 2018/2019.
Authors: S Novitasari
Published: July 2019

This study aims to determine the learning outcomes of class XI students in Tugumulyo State Senior High School 2018/2019 Academic Year after using the physics-based teaching material of elasticity and hooke’s law and to find out the students response to learning using the higher order thinking skills approach to elasticity and hooke’s law material of class XI students at Public High School Tugumulyo 2018/2019 Academic Year. The population of this study were all students of class XI and the subject of this study consisted of 34 students of class XI IPA 5 of State Senior High School Tugumulyo. Data collection is done by questionnaires, tests, and observations. The overall percentage of teaching material components was 79,24% (very good). The percentage of student responses to higher order thinking skills -based teaching materials is 76,53% (very good). In addition, from the results of daily test tests, the effectiveness percentage of 88.89% (very good) of students who scored above 70 out of 10 test items. The value of t count> t table with the value of t count = 2,13and t table = 1,697. So that the use of higher order thinking skills -based teaching materials can be said to be valid, practical and effective.
Perencanaan Strategis Sistem Informasi Dinas Perhubungan Kota Sukabumi dengan Metode Ward and Peppard
Authors: Jaenudin Jaenudin , Permana Budi
Published: July 2019

Penerapan sistem informasi di Dinas Perhubungan (Dishub) Kota Sukabumi memerlukan suatu kerangka kerja perencanaan strategis yang dapat membatu mengoptimalkan peran organisasi, meningkatkan value, serta menciptakan keunggulan kompetitif. Penelitian ini bertujuan untuk membuat perencanaan strategis sistem informasi Dishub Kota Sukabumi dengan metode Ward and Peppard. Dalam menyusun kerangka kerja perencanaan strategis, digunakan tools analisis seperti SWOT, PEST, 5 Force Porter, Critical Success Factors, dan Mc Farland’s Strategic. Di dalam kerangka kerja yang dibuat, terdapat beberapa hal yang sebaiknya perlu diperhatikan oleh Dishub Kota Sukabumi seperti portofolio aplikasi di masa mendatang. Hal tersebut perlu diperhatikan agar apa yang diterapkan nantinya dapat berjalan dengan baik dan sesuai dengan apa yang diharapkan. Dengan adanya perencanaan strategis sistem informasi ini, Dishub Kota Sukabumi diharapkan dapat memiliki sistem informasi sebagai solusi total berbasis pengetahuan dengan infrastruktur dan SDM yang handal. Selain itu, diharapkan sistem informasi ini dapat digunakan untuk mengoptimalkan pelayanan bisnis, mendukung pengambian keputusan, dan menetapkan strategi bisnis yang tepat untuk jangka panjang.
Studi Tentang Keamanan Pejalan Kaki di Kampus Unsika Menggunakan Uji Wilcoxon Signed Rank dan Aplikasi SPSS
Authors: Dampang Sarah , Ramayanti Cindy , Nugraha Billy
Published: July 2019

Keselamatan pejalan kaki di lingkungan kampus sangatlah penting untuk diperhatikan. Banyaknya lalu-lalang kendaraan seperti motor, mobil, dan kendaraan lainnya di lingkungan kampus menjadi beberapa hal yang dapat membahayakan para pejalan kaki. Penelitian ini dilakukan sebagai studi awal untuk mengetahui bagaimana kondisi yang menunjang keamanan pejalan kaki di Kampus Universitas Singaperbangsa Karawang (Unsika) guna menghindari kecelakaan lalu lintas yang tidak diinginkan. Metode pengumpulan data yang digunakan dalam penelitian ini adalah melalui dokumentasi, angket, dan wawancara. Analisa uji coba yang digunakan adalah uji Wilcoxon Signed Rank dan menggunakan aplikasi SPSS (Statistical Products and Service Solution) versi 23. Hasil penelitian menunjukan bahwa dari 200 responden yang merasa tidak aman berjalan kaki di Kampus Unsika sebesar 77%. Selain itu, dari segi kenyamanan, pejalan kaki di lingkungan Kampus Unsika belum merasa nyaman. Hal ini ditunjukkan dari hasil pengamatan yang diperoleh 85% responden tidak merasa nyaman. Untuk meningkatkan rasa keamanan dan kenyamanan, persentase responden membutuhkan fasilitas seperti trotoar, rambu-rambu, dan peneduh jalan berturut-turut sebesar 92%, 86%, dan 77%.
Analisis Kategori Iklan Berbasis Facebook Ads untuk UKM
Authors: Hadining Aulia Fashanah , Sari Elfrida Iriana , Kusnadi Kusnadi
Published: July 2019

Pertumbuhan pengguna internet yang cepat serta jumlah pengguna social media Facebook yang menduduki peringkat pertama dibandingkan dengan social media lain di Indonesia, membuka peluang besar bagi para pelaku Usaha Kecil dan Menengah (UKM) untuk menggunakannya sebagai media pemasaran yang efektif dan efisien. Penelitian ini bertujuan untuk menganalisis kategori iklan berbasis Facebook Ads sebagai media promosi UKM. Metode yang digunakan adalah dengan menguji tiga tipe gambar dan empat lokasi iklan Facebook yaitu Desktop Facebook (News Feed), Mobile Messenger (Messenger Home), Mobile Instagram (News Feed), dan Mobile Facebook (News Feed). Dari pengujian tersebut, akan diperoleh data hasil pengujian iklan yang diukur tingkat efektivitas dan efisiensinya berdasarkan metrik iklan reach, Unique Click Through-Rate (UCTR), Unique Click, dan Cost per Unique Click (CUC). Ketiga iklan Facebook tersebut dilakukan uji perbandingan iklan ke dalam setiap metrik pengukuran iklan. Hasil analisis diperoleh iklan paling efektif dan efisien adalah iklan dengan lokasi Mobile Facebook (News Feed). Diperoleh jumlah klik iklan sebanyak 3.449 unique click, biaya iklan Rp. 2.000,00 sampai Rp. 2500,00 per klik yang masih terjangkau, serta nilai UCTR adalah 120% dibagi 8 hari diperoleh 15%.
Pembuatan Serbuk Mangan Sulfat dari Pelindian Bijih Mangan Kadar Rendah dengan Metode Kristalisasi
Authors: Royani Ahmad
Published: July 2019

Mangan Sulfat adalah bahan baku penting dalam produksi beberapa senyawa mangan di berbagai industri. Oleh karena itu, pembuatan Mangan Sulfat dari bijih mangan kadar rendah untuk produksi senyawa dengan kemurnian yang tinggi menjadi hal yang sangat penting. Untuk membuat serbuk MnSO4.H2O dengan kemurnian tinggi dari larutan hasil pelindian bijih mangan, maka perlu dilakukan proses kristalisasi. Penelitian ini bertujuan untuk membuat serbuk Mangan Sulfat dari pelindian bijih mangan kadar rendah dengan metode kristalisasi. Kristalisasi dilakukan pada setiap sampel sebanyak 500 mL larutan Mangan Sulfat pada suhu ± 98oC dalam berbagai waktu. Kemudian didinginkan pada temperatur kamar ± 30oC dan pada media air es ± 3oC. Analisis kadar mangan sebelum dan sesudah proses kristalisasi dilakukan menggunakan Atomic Absorption Spectrometer. Morfologi serbuk produk mangan dikarakterisasi menggunakan Scanning Electron Microscope yang dilengkapi dengan Energy Dispersive Spectrometer. Hasil kristalisasi sangat efektif untuk menghilangkan unsur pengotor dalam serbuk MnSO4.H2O. Unsur pengotor mengalami penurunan sebesar 99,15% dan 98,96% dalam proses kristalisasi dengan pendinginan di udara dan pendinginan menggunakan air es. Sementara itu, serbuk kristal yang dihasilkan mengandung lebih dari 98% MnSO4.H2O dengan unsur pengotor dibawah 2%. Serbuk kristal pada pendinginan udara cenderung memiliki struktur yang lebih teratur dan berukuran relatif lebih kecil dibandingkan dengan struktur dan ukuran kristal pada pendinginan air es.
Kajian Tekno Ekonomi Upgrading Biogas Berbasis POME Dengan Teknologi Water Scrubber
Authors: Sugiyono Agus , Juwita Asmi Rima , Hastuti Zulaicha Dwi , Fitriana Ira
Published: July 2019

Biometana dari POME (palm oil mill effluent) merupakan energi terbarukan yang dapat dimanfaatkan sebagai substitusi gas alam dan LPG. Produksi biometana dapat mencapai 10% dari konsumsi gas bumi saat ini atau setara dengan 20% dari konsumsi LPG bila keseluruhan kapasitas produksi pabrik kelapa sawit dioptimalkan. Salah satu teknologi untuk produksi biometana yang sudah komersial untuk skala industri adalah water scrubber. Penerapan teknologi ini, khususnya di pabrik kelapa sawit Sei Pagar, Riau dengan kapasitas 250 Nm3/jam, belum ekonomis. Makalah ini bertujuan untuk melakukan kajian tekno ekonomi upgrading biogas berbasis POME dengan teknologi water scrubber. Berdasarkan hasil kajian yang dilakukan, biaya investasi upgrading biogas plant mencapai 53,2 miliar rupiah, sedangkan biaya operasi dan perawatannya mencapai 8,3 miliar rupiah. Harga biometana masih lebih mahal dari pada harga gas bumi sebesar 5,62 USD/MMBTU. Pada harga gas di atas 18,5 USD/MMBTU, upgrading biogas plant layak untuk dikembangkan. Kendala yang dihadapi dalam mencapai kelayakan adalah biaya investasi yang mahal serta harga gas bumi yang lebih murah. Berbagai kebijakan seperti transisi energi dan feed in tariff untuk energi terbarukan serta penerapan biaya eksternalitas dan depletion premium untuk energi fosil diharapkan dapat mendorong kelayakan penggunaan biometana berbasis POME di masa mendatang.
Perancangan Sistem Pemantau dan Pengendali Alat Rumah Tangga Berbasis NodeMCU
Authors: Saputra Dede Irawan , Fajrin Isti Maulani , Zainal Yuda Bakti
Published: July 2019

Seiring padatnya aktivitas di luar rumah, penghuni rumah terkadang mengalami kesulitan dalam memantau dan mengendalikan peralatan elektronik yang terdapat di rumah. Salah satu alternatif pemantauan peralatan elektronik dapat memanfaatkan fasilitas internet sebagai media pembawa dan penerima informasi dengan keunggulan dapat diakses di manapun dan kapanpun. Penggunaan divais mikrokontroler yang terintegrasi dengan sensor dapat menjadi salah satu solusi untuk memudahkan penghuni rumah agar dapat memantau status perangkat elektronik dari jauh melalui sebuah aplikasi pada smartphone-nya. Pada penelitian ini, dikembangkan sebuah divais pemantau dan pengontrol alat rumah tangga berbasis internet sebagai media informasi status peralatan rumah tangga. Mikrokontroler NodeMCU digunakan sebagai pengolah data dan pengendali yang terintegrasi dengan modul WiFi. Sensor yang digunakan adalah sensor arus ACS712. Pada penelitian ini variabel yang dipantau adalah daya penggunaan alat rumah tangga pada sebuah dispenser. Pembuatan alat pemantauan tersebut dilengkapi dengan perangkat lunak Blynk dan IFTTT. Hasil penelitian menunjukkan bahwa peralatan elektronik rumah tangga dapat dikendalikan menggunakan smarthphone dari jarak jauh dan dapat memantau status alat rumah tangga beserta mengetahui konsumsi daya dan biaya yang digunakan. Kelebihan dari perangkat pemantauan adalah jarak tidak berpengaruh pada alat. Akan tetapi, koneksi internet yang terhubung pada alat sangat berpengaruh untuk mengendalikan alat elektronik rumah tangga.
Research of antimicrobial efficacy of modern antiseptic agents based on decamethoxine and povidone-iodine
Authors: Nazarchuk Oleksandr
Published: July 2019

Under conditions of wide increased resistance of pathogens of infectious complications to antimicrobial agents, a considerable attention is paid to the use of antiseptic drugs. The research of their antimicrobial efficacy remains valid for substantiation of the rational use. The purpose was to carry out a comparative study of the antimicrobial efficacy of medicinal antiseptic agents based on decamethoxine and povidone-iodine.

In the study there was examined antimicrobial activity of mentioned antiseptics against 682 clinical strains of microorganisms (A. baumannii, S. aureus, P. aeruginosa, Enterococcus spp., E. coli, Enterobacter spp., K. pneumoniae, Proteus spp.), isolated from patients with infectious complications. Minimum inhibitory and bactericidal concentrations of 1–2– 10 % iodine, 0.02 % decamethoxine (decasan) were determined. Antimicrobial efficacy of medicines, based on studied antiseptics was evaluated with the use of an index of antiseptic activity, calculated by means of commonly used methods.

The study revealed high bactericidal properties of decasan against clinical strains of S. aureus, Enterococcus spp., E. coli, K. pneumoniae and Enterobacter spp. The advantages of antimicrobial activity of decamethoxine-based antseptis (decasan, p < 0.001) were proved. Iodine has expressed antimicrobial properties against Enterococcus spp., S. aureus, A. baumannii, bacteria of the Enterobacteriаcеae family and P. aeruginosa. It is proven that the dissolution of povidone-iodine leads to the reduction of the antimicrobial efficacy of 2 % antiseptic solution. There was found inefficacy of 1 % povidone-iodine against infectious agents (p < 0.001).

Thus, the leading Gram-positive (S. aureus, Enterococci) and Gram-negative pathogens (Escherichia, Klebsiella, Enterobacteria, Acinetobacteria, Pseudomonas) have a sensitivity to iodine and to domestic preparation based on decamethoxin 0.02 % (decasan), with a definite advantage of the antimicrobial properties of the latter to Gram-positive and some Gram-negative microorganisms (p < 0.001).
Formação acadêmico-profissional de professores(as)
Authors: Mello Elena Maria Billig , Salomão de Freitas Diana Paula
Published: July 2019

Este é um verbete sobre a formação acadêmico-profissional de professores(as) que poderá compor o "Dicionário crítico de formação de professores" desta Revista.
Being a Girl Who Gets into Trouble
Authors: Arnull Elaine
Published: July 2019

In this article I focus on the narratives of girls who describe the events that shape their lives and get them into trouble. The narratives are explored against Darrell Steffensmeier and Emilie Allan’s (1996) proffered Gender Theory, to consider whether it offers an adequate explanatory framework. The article adds to the body of knowledge about girlhood, gender norms, and transgression and provides fresh insight into the relevance of physical strength to girls’ violence. I conclude that girls are defining girlhood as they live it and it is the disjuncture with normative concepts that leads them into conflict with institutions of social control.
Hydrogeochemistry of urban areas in the Southern Urals
Authors: Abdrakhmanov R. F.
Published: July 2019

On the basis of full-scale studies the features of the formation of the chemical composition of groundwater in urban areas of the Southern Urals have been clarified. Changes in the salt composition of pore solutions of clay rocks and their exchange-adsorption properties, distribution and accumulation of supertoxicants in rocks and water have been established. The influence of changes in the chemical composition of water on hazardous geological processes was evaluated. It was found that the most intense impact of the geological environment is exposed to the surface to a depth of 15-20 m. Dioxins and heavy metals in soils on the territory of industrial enterprises are concentrated in the near-surface zone (up to 5-7 m). In the range of depths from 5-7 m to 20 m their content is significantly reduced. Liquid organic pollutants and water-soluble salts penetrate almost the entire zone of active circulation. The processes of self-purification of aquifers and restoration of natural conditions even after the elimination of the source of pollution continue for tens or even hundreds of years, i.e. exceed the life of one generation.
La influencia de las devoluciones de IVA en el capital de trabajo para productores de huevo en Sabana Centro
Authors: Guevara Garzón Catherine Ninoska
Published: July 2019

Introducción. El sector productor de huevos en la sabana centro se ve enfrentado a nuevos retos con la Ley 1819 de 2016, que gravó con nuevos tributos e implantó nuevos procedimientos para gozar de los beneficios del sector primario en el Impuesto del IVA.  Objetivo. Se hace necesario entones poder identificar las principales características de la facturación electrónica en Colombia y los beneficios a nivel de procedimiento tributario.  Materiales y métodos. Investigación cuantitativa basada en analizar información de las microempresas en el área de devoluciones de IVA. Resultados. Se evidencia la trazabilidad del comportamiento de las solicitudes de este impuesto con respecto al capital de trabajo. Conclusión. Se concluye que debe haber una armonía total al momento de presentar los impuestos y solicitar las devoluciones en forma ágil y oportuna, para garantizar un flujo de efectivo constante en las entidades.
Investigation of the Pathogenesis and Treatment Efficiency of Bevacizumab-Induced Hypertension in the Rat Model
Authors: Balci Mehmet Ali , Özyiğit Musa Özgür , İpek Volkan , Kafa İlker Mustafa , Kurt Ender
Published: July 2019

Bevacizumab is known to reduce Vascular Endothelial Growth Factor (VEGF) to undetectable levels when used in conjunction with chemotherapy. Hypertension is a frequent adverse effect of bevacizumab, although its mechanism(s) remain unclear. In this study, our aim was to examine the pathogenesis of bevacizumab-induced hypertension and to investigate the treatment efficacy of valsartan. A total of 24 Wistar Albino female rats were included in the study. Rats were divided into three groups with 8 rats in each, as follows: The control group, bevacizumab group and bevacizumab + valsartan group. Blood pressure, blood urea nitrogen and serum creatinine levels were measured, urine samples were collected for 24 hours statistical analyses were performed using IBM SPSS 20 software pack. Nephrectomy specimens in bevacizumab and bevacizumab + valsartan groups exhibited varying degrees of renal injury. Although valsartan was able to reduce the bevacizumab-induced rise in blood pressure, it could not prevent the development of nephropathy. Conclusions these findings suggest that hypertension occurring secondary to bevacizumab treatment in rats may be associated with mechanisms involving renal injury.
Prognostic Value of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Lung Cancer
Authors: Beyhan Sagmen Seda , Dogan Coskun , Comert Sevda , Kiral Nesrin , Fidan Ali , Torun Parmaksiz Elif
Published: July 2019

Numerous studies determined that the neutrophil/lymphocyte (NLR) and platelet/lymphocyte ratios (PLR) had prognostic value in several cancer types. This study aimed to evaluate the relationship between NLR and PLR values with the survival time of lung cancer patients. Patients diagnosed with lung cancer between January 2014 and December 2016, were retrospectively evaluated. Demographic characteristics, disease stages, laboratory parameters recorded, and the relationship of NLR and PLR values with the survival time and the disease stage evaluated. NLR and PLR were categorized into two groups. SPSS 17.0 software package was used for the statistical analysis. ROC analysis, Student T-test, Chi-square, and Mann-Whitney U test were used. Mean age of 62±8 years were included in the study. In the NSCLC group, the average NLR and PLR values were 4±3.35 and 194.6±144.4 respectively. Regarding the NSCLC group, the overall survival time was shorter in the subgroup with an NLR >3.43 (13.1 months) compared to the subgroup with an NLR ≤3.43 (24.3 months). The mean survival time was shorter in the group with a PLR > 136.9 compared to the group with a PLR ≤136.9 (15.9 and 24.6 months respectively). Subgroups consisting of survivors and non-survivors in the NSCLC group showed a statistically significant difference considering neutrophil and lymphocyte count, CRP, NLR, and PLR values (p<0.05). As NLR and PLR values are easily accessible, they have an essential role in the prognosis of lung cancer as well as other cancer types.
Science Communication and Education of Future Researchers. To the Question of Teaching the History and Philosophy of Science at University
Authors: Shipovalova L. V.
Published: July 2019

The article aims to legitimate teaching the history and philosophy of science at contemporary Russian university. It assumes to contribute to the answering the questions of what and how should future researchers and science teachers be taught. It attempts to complement the relevant researches with one aspect connected with the communication of scientists as a subject of study and education. The author argues that the theory and practice of communication can be an important element of teaching the history and philosophy of science courses for future researchers. She explains this importance by two reasons. Firstly, the communication of scientists is problematic; secondly, it can be interpreted as a condition for innovative research. The author makes a distinction between professional communication in science and science communication of scientists with other public actors. The main problem of communication between scientists is an ambiguous connection between the goals of these two types of communication. The article answers the following issues: why and how future researchers should be taught the theory and practice of these two types of communication. In the last part of the article the author analyzes the method of teaching and describes three educational strategies: historical critique, philosophical assembling and experience of dialogue. All of them can be an integral part of teaching the history and philosophy of science for future researchers.
Theory and Practice of Using Robotics in Educational Process
Authors: Ruslyakova E. E. , Pustovoitova O. V. , Kiseleva Yu. P. , Yakovleva L. A.
Published: July 2019

This article discusses the problem of using robotics in higher education, highlights the theoretical and practical aspects of the problem. The article describes the current trend of the inclusion of robotics in the educational process as one of the effective tools for the formation of students’ professional competencies, psychological readiness to implement educational programs at any level in the modern post-industrial world. The authors present psychological and pedagogical research, in which the organization of project work with fourth-grade and fifth-grade students was studied using a robot-assistant. Practical research was devoted to the perception of anthropomorphic robots by students. They studied a number of disciplines in direct contact with a static robot. The authors analyzed the possibility of using robotics in educational process while preparation of students majoring both in engineering and pedagogy. The results of this research support the idea that robots can be assistants for a teacher and motivators for students. Interaction between robot and students enhances their general emotional background, activates cognitive processes and learning in general.
EFFECT OF MODIFICATION OF THE EXTRACTION TECHNIQUE OF THE SUBSTANCE IN A SOXHLET FOR CONTENT OF FATTY ACIDS
Authors: Natrus L.V. , Kryvosheyeva O.I. , Lamazyan G.R. , Bruzgina T.S.
Published: July 2019

Relevance. The search for new forms of herbal medicine is an important area of modern biotechnology, pharmacology and pharmacy. More and more attention is paid to the development of extracts from plant materials, since the extraction products provide the maximum content of biologically active substances, which increases the rationality of their use, due to the accuracy of dosing, the therapeutic effect is increased, the period of use increases and storage conditions are simplified. The extraction of the fruit mixture of Citrullus сolocynthis in the Soxhlet apparatus was modified by reducing the procedure time 5-10 times and improving the processing of raw materials by using a press at the same time and increasing the temperature, or even by modifying the apparatus.

Objective: to study the composition of FA in an aqueous solution of the dry extract of Citrullus сolocynthis when modifying the extraction mixture in the Soxhlet apparatus by increasing the temperature and technological reduction of processing time.

Materials and methods. We carried out the determination and comparison of the composition of FA’s by gas-liquid chromatography of all parts of the fruit of Citrullus сolocynthis and in an aqueous solution of its dry extract with various concentrations of the substance.

Results. Chromatographic analysis showed that all parts of the fetus Citrullus colocynthis are promising sources of saturated and unsaturated FA. In all parts of the fruit of Citrullus colocynthis, linoleic acid prevails in quantitative content. The modification of the extraction of the mixture in the Soxhlet apparatus by increasing the temperature and technological reduction in the processing time of the raw materials led to the production of a substance with a new composition and FA content. The ratio of unsaturated / saturated FA in the resulting dry extract is 5 times greater than the similar ratio separately in seeds, pulp and shell. At the same time, the distribution of separate unsaturated and polyunsaturated FA’s in the dry extract solution is fairly uniform. The relative amount of linoleic FA in the dry extract was smaller, and the linolenic FA was greater than in the seeds and pulp of the fruit.

Conclusions. Modifying the extraction of the mixture in the Soxhlet apparatus by increasing the temperature and technological reduction of the processing time did not lead to complete degreasing of the substrate and allowed to obtain a dry extract of Citrullus solvent with content of microdoses of the FA, their balanced (uniform) in amount, and predominance of 5 times the amount of unsaturated polyunsaturated FA over the amount of saturated. We assume that such a redistribution of FA, and especially their micro doses, can be the basis for creating medicines with more effective effects on the body.
INTRAPERITONEAL USING OF BUPIVАCAIN FOR THE ANESTHESIA OF PATIENTS AFTER LAPAROSCOPIC CHOLECYSTECTOMY
Authors: Glumcher F.S. , Solyaryk S.O. , Oliynyk O.V. , Kolosovych A.I.
Published: July 2019

Relevance. The local anesthetics were used intraperitoneally after some minimally invasive gynecological interventions like a component of postoperative multimodal anesthesia in recent years.  

Objective. The aim of  work was to study the effectiveness of intraperitoneal administration  of bupivokain  for the anesthesia of patients after laparoscopic cholecystectomy.

Material and methods. 28 patients aged 32-60 years  (16 women, 12 men) were examined. The patients were divided into two groups. In the first group for anesthesia after the operation, was used ketorolac trometamine in dose 0.2 mg/kg intramuscularly each 6 hours. If the patient complained of postoperative pain, which was assessed by Visual-analog scale in 7 points or higher, fentanyl was administered intramuscularly in dose of 0.003 μg/kg. In the second group, besides the components of multimodal anesthesia used in the first group, at the end of the surgical intervention at the drainage tubes were injected 40 ml of 0.125% solution of bupivocaine (50 mg). This injection was repeated throughout the first day each 6 hours. The condition of patients was assessed by a Visual-analog scale after 1, 4, 8, 12 and 24 hours after the finishing of surgery. The average dose of fentanyl in μg/kg used for postoperative anesthesia  first 24 hours after operation was also determined.

Results.  We have received a significant reduction in the rates of pain evaluation for Visual-analog scale in patients who used bupivacaine as a component of multimodal anesthesia. One hour after the end of the operation, the pain score for Visual-analog scale was less than the corresponding one in the control group in 1.77 times, after 4 hours – in 1.47, and in 8 hours – in 1.55 times. In all cases, P <0.001. The mean dose of fentanyl used for treatment in the study group was 1.55 times less than that in the control group. There were no significant complications in both groups. A patient in group 1 had nausea, requiring a single dose of ondasetron 2 mg

Conclusion. Intraperitoneal administration of bupivocaine had a significant  anesthetic effect after laparoscopic cholecystectomy.
A GENETIC STUDY OF PATIENTS WITH CHRONIC VENOUS INSUFFICIENCY BASED ON CLINICAL AND GENEALOGICAL METHOD
Authors: Korolova Kh.O. , Teplyi V.V.
Published: July 2019

Relevance. Practically 10-15 % of the world's population has varicose veins as a manifestation of chronic venous insufficiency. The clinical and genealogical method is the method allows to identify family cases of disease in patients with chronic venous insufficiency.
Objective: to demonstrate the role of heredity in varicose disease, to analyze family cases of varicose disease, to determine the type of disease inheritance and to give a prediction of heredity for descendants, using the clinical and genealogical method.
Materials and methods. The study involved 72 patients, mostly women – 46 (63.9 %) persons, with different classes of varicose veins according to the CEAP classification. To determine the type of inheritance we used clinical and genealogical method of pedigrees’ study. The nature of the trait – hereditary or non-hereditary disease; type of the inheritance – autosomal-dominant, autosomal-recessive, sex-linked, were defined.
Results. The family nature of the varicose disease was revealed in 17 (23 %) of the 72 examined patients. The autosomal-dominant type of inheritance was determined. There is direct inheritance across generations.
Conclusions. We determined the family nature of the disease inheritance, with the autosomal-dominant type of inheritance with a high degree of gene expression. In these families there is a high risk of the birth of the children who will have chronic venous insufficiency.
ANALYSIS OF WORKING CONDITIONS ON THE STATE OF EALTH WORKERS IN THE TEXTILE INDUSTRY
Authors: Zavada M.I.
Published: July 2019

Relevance. The textile industry is one of the leading industries in the light industry, in which most workers are women. However, manufacturing technologies are harmful, and equipment of enterprises is outdated. Therefore, the optimization of working conditions in the industry is extremely relevant and important for improving the demographic situation in Ukraine.

Objective: to analyze literary data on working conditions in the textile industry, to identify the main hazards in the industry and their impact on the health of workers.

Method. Retrospective search in Ukrainian scientific sources for 2003-2015.

Results. Influence chemical (dyes, acids, alkali, formaldehyde, carbon disulfide, chlorine compounds); physical (noise, vibration, microclimate); biological factors (microorganisms in the raw material); as well as unfavourable factors of the labour process (static load, slopes of the case, awkward posture, tension of the muscles of the hands and eyes) and dust onto textile workers It was found. Workers experience changes in the functional state of the central nervous system (vegetative-vascular disorders, hearing loss); respiratory tract (laryngotracheitis, bronchitis, bronchial asthma, bisynosis); bone marrow (flatfoot, osteochondrosis, varicose disease, radiculitis); genital system (violation of reproductive function); skin diseases (dermatitis, burns) and eyes (conjunctivitis, cataracts).

Conclusions. The combination of chemical agents, noise and vibration is a leading factor in the negative impact on the health of workers in the textile industry.
The Role of Recombinant Human Cyclophilin A in the Antitumor Immune Response
Authors: Kalinina A. A. , Silaeva Yu. Yu. , Kazansky D. B. , Khromykh L. M.
Published: July 2019

Cyclophilin A (CypA) is a multifunctional protein that exhibits an isomerase activity and exists in the intracellular and secretory forms. Secretory CypA promotes regeneration of the hematopoietic and the immune systems of an organism by stimulating stem cell migration from the bone marrow. New approaches based on CypA are currently being developed for the treatment of limb ischemia, neutralization of the side effects of Cyclosporine A (CsA) therapy, etc. However, the role of CypA in the antitumor immune response is still unexplored. In this work, we used the model experimental system of lymphoma EL-4 rejection in B10.D2(R101) mice and showed that recombinant human CypA (rhCypA) stimulates the antitumor immune response via early recruitment of granulocytes to the tumor cell localization site and rapid accumulation of effector T-killers