bluuebunny/crossref_metadata_2025 huggingface dataset:
An Overview of Concepts and Applications of Fintech with Emphasis on Simulation and Artificial Intelligence
Authors: Sharma Suman , Chopra Kamal Nain
Published: May 2023

This paper discusses the Concepts and Applications of Fintech with emphasis on Simulation and Artificial intelligence for Optimization of the Financial outputs. The true amalgamation of the two topics (Finance and Technology) has taken place to give rise to Fintech, a topic which is evolving very fast in recent times. This paper is expected to be very useful for the researchers and managers engaged in this important field.
A COMPARISON OF KINETIC STUDIES OF KAOLIN CLAY AND RICE HUSKS FOR CIPROFLOXACIN ADSORPTION
Authors: SINBAH HAYFAA JASIM , KHAZAAL MAJIDA HAMEED , HASSEN HUDA SABAH , HASSAN EKHLAS SABAH
Published: May 2023

Objective: to compare the absorption of this drug on two surfaces of Iraqi kaolin and rice husks, which are considered environmentally friendly natural products and available locally.
Methods: Ciprofloxacin adsorption from an aqueous solution was studied with respect to contact time, pH, and concentration. 30 min was determined to be the equilibrium time. Increasing the drug concentration on both adsorbents increased the adsorption rate, and the data fit well into a pseudo-second-order model. The solution concentration was analysed by UV-visible spectroscopy. Then the amount of adsorption was calculated, as well as the study of the reaction kinetics for both surfaces. The rice husk adsorbent showed faster removal with higher uptake than the Kaolin clay in both SGF and SIF solutions.
Results: The adsorption isotherms of type (S4, S2) were found on the surface of rice husks and kaolin clay type (L3, L4) in stomach and intestine fluids, respectively. On Iraqi kaolin clay, adsorption is well described by the pseudo-second-order model, and the Tempkin adsorption isotherm provides a good fit for the Stomach. Whereas adsorption on rice husk is well described by the Freundlich isotherm, which is a good fit for the intestine. the adsorption is predominantly physical. The best maximum adsorption capacities were calculated on both surfaces in the following order: stomach-kaolin>intestinal fluids-rice husks>stomach-rice husks>intestinal fluids-kaolin.
Conclusion: Both kaolin and rice husk are possible adsorbents that could be used to get antibiotics out of water.
THE INFLUENCE OF CATHARANTHUS ROSEUS (L.) G. DON. ETHANOL EXTRACT IN CLOVE OIL NANOEMULSION: PHYSICAL CHARACTERIZATION, ANTIOXIDANT AND ANTIBACTERIAL ACTIVITIES
Authors: LAILA LIA , CANDRA ANDY , PERMATA YADE METRI , PRASETYO BAYU EKO
Published: May 2023

Objective: This study aimed to develop a topical nanoemulsion using clove oil and ethanol extract of catharanthus roseus (L.) G. for antioxidant and antibacterial dosage form.
Methods: The nanoemulsion was produced using a spontaneous emulsification method. The formulation was carried out using tween 80 and pluronic 127 as surfactants with different extract concentrations (0.5–2%). The characterizations of the formula included organoleptic test, homogeneity, pH determination, emulsion type, viscosity, particle size determination, zeta potential, and stability test were evaluated. Antioxidant activity was conducted using DPPH method and antibacterial activity was determined against propionibacterium acnes and Staphylococcus epidermidis.
Results: The result showed that all the formulations produced a stable nanoemulsion with semisolid, clarity, transparent and homogenous characteristic. The nanoemulsion had pH of 5.5-6.5 and belong to oil in water (O/W) type of emulsion. The formula showed viscosity ranged from 121.33±0.29 until 211.01±1.00 cps, had particle size below than 300 nm, and were stable for 3 mo of storage and after accelerated evaluation. nanoemulsion contained 2% of c. roseus extract showed moderate antioxidant activity with IC50 value of 96.29±3.64 and antibacterial activity with 10.65±0.15 and 13.27±0.21 mm of inhibition zones for propionibacterium acnes and Staphylococcus epidermidis, respectively.
Conclusion: Clove oil combined with the ethanol extract of c. roseus produced a stable nanoemulsion, which demonstrated concentration-dependent antioxidant and antibacterial activities.
PLACENTA EXTRACT-LOADED NOVASOME SIGNIFICANTLY IMPROVED HAIR GROWTH IN A RAT IN VIVO MODEL
Authors: ROSALINA AJENG I. , ISKANDARSYAH  , SAGITA ERNY
Published: May 2023

Objective: This study aims to improve the hair-growing effect of bovine placenta extract (PE) by loading it to a novasome vesicle.
Methods: PE-loaded novasome was prepared by thin layer hydration method. A 23 full factorial design was used to obtain the most optimum formula by varying the type of surfactants, the type of free fatty acid (FFA), and the ratio of surfactants and FFA. The resulting PE-loaded novasomes were characterized by entrapment efficiency (%EE), particle size (PS), polydispersity index (PDI), and zeta potential (ZP).
Results: PE-loaded novasome composed of Span 60: cholesterol: oleic acid (10:10:3) demonstrated the most optimum characteristics with PS 155.0 nm; PDI 0.139; ZP-63.73 and EE 79.60%. Transmission electron microscopy (TEM) of the most optimum novasome revealed non-aggregating oligo-lamellar nanovesicles. In addition, novasome showed ultra-deformable properties and good stability during 90 d storage at 4 °C. A hair growth study in rats showed that the PE-loaded novasome demonstrated better hair-growing effect compared to PE-loaded liposome and minoxidil 2% solution.
Conclusion: Novasome is a potential carrier for bringing such a big molecule as PE. PE-loaded in novasome showed vesicles with good physical characteristics and In vivo assessment demonstrated better hair-growing effect than minoxidil and PE-loaded liposomes.
STRUCTURE-BASED DRUG DESIGN METHOD: MOLECULAR DOCKING STUDY AND PHARMACOPHORE MODELLING OF APIGENIN AS AN ANTIMALARIAL
Authors: HERMANTO FAIZAL , SYAM AKHIRUL KAHFI , HAQ FAHMY AHSANUL , RACHMAWAN R. LUCKY
Published: May 2023

Objective: Uses molecular docking and pharmacophore modeling methods to examine the antimalarial activity of apigenin (API) on distinct kinds and varieties of P. falciparum (Pf) receptors.
Methods: Using Autodock 4.0.1 and ligandscout software, molecular docking was conducted on multiple types of Pf receptors, including lactate dehydrogenase (Oxidoreductase), Enoyl-acyl carrier-protein (Oxidoreductase), Triose-phosphate (Isomerase), and plasmepsin II (Hydroxylase).
Results: The lowest free energy binding values found in two of the four investigations (API on an enoyl-acyl carrier and triose-phosphate receptors) suggested a potential effect. These values were-8.06 kcal/mol and-8.76 kcal/mol, respectively. The API had lower values of the inhibitory constant on the lactate dehydrogenase, enoyl-acyl carrier-protein, Triose-phosphate, and plasmepsin II receptors (44.06 µM, 1.24 µM, 376.76 nM, and 57.04 µM, respectively). In terms of the essential elements of amino acid residue interaction, the API and the native ligand were identical (SER218 for 1LF3 receptor; LEU315, GLY110, and TYR111 for 1NWH receptor; VAL212, LYS12, ASN233, and GLY232 for 1O5X receptor; and ILE31, PRO250, and PRO246 for 1U4O receptor). According to the findings of the pharmacophore modeling, the functional groups of hydroxyl were the most important functional groups to interact with the important amino acid residues of the receptors.
Conclusion: The API considerably displays competitive antimalarial potency in various Pf receptors.
On some P-Q modular equations of degree 45
Authors: Sharath G.
Published: May 2023

On page 330 of his second notebook, Srinivasa Ramanujan recorded a P-Q modular equation of degree 45, proof of which has been given by Bruce C. Berndt via theory of modular forms. We in this paper, give a simple proof of the same using the identities of Ramanujan and also establish few new P-Q modular equations of degree 45. Further using these, we establish certain new modular equations of signature 3.
Formulation and Evaluation of Herbal Shampoo from Spinacia Oleracea Leaves, Ipomoea Batatas Extracts
Authors: Gupta Laxmi
Published: May 2023

Abstract: The current aimed to formulate herbal shampoo and to evaluate the various property of herbal shampoos. The herbal shampoo was formulated by adding the extracts of Spinacia Oleracea leaves, Ipomoea batatas roots, Acacia concinna, Sapindus Indica, Cymbopogon citrus in different proportions to a 100 ml. Small amount of gelatin and citric acid were also added for viscosity and pH respectively. Several tests such as visual inspection, pH, dirt dispersion, rheological evaluation and skin irritation test etc, were performed to determine the physicochemical properties of prepared shampoos. The formulated herbal shampoo was clear and appealing. It showed good cleansing and detergency and good foam stability. The results indicated the formulated shampoo is having excellent conditioning performance, similar to commercially available shampoo. However, further research and development is required to improve its quality and safety.
MAHAPARIWAR Application
Authors: Prachi Ashtivkar , Bhargavi Lakeshri , Sagar Misal , Mihir Patil
Published: May 2023

Abstract: An Android family app aims to providea platform for family members to communicate and stay connected with each other. This app is designed to have a user-friendly interface that allows family members to share their schedules, create shopping lists, and share important documents, such as emergency contacts and medical information. It also features a built-in messaging system that enables users to send text,voice, and video messages to each other. The appwill also allow users to create and share events, such as family gatherings, birthdays, and anniversaries, and receive reminders for these events. The primary objective of this app is to foster communication and strengthen the bond between family members by providing them with a centralized platform for staying connected.
The Relationship between Loneliness and Psychological Distress among Young Adults
Authors: Jo Femi
Published: May 2023

Abstract: The purpose of the present study is to assess the relationship between loneliness and Psychological distress among young adults. The study also assesses whether there are significant difference in gender with respect to loneliness and psychological distress. A sample of 100 young adults (50 males, 50 females) aged between 18-25 years participated in the study. The UCLA Loneliness Scale Revised Version 3 designed by Russel D. (1996) and the Kessler Psychological distress Scale (K10) developed by Kessler R. (2003) were used to measure the variables in the study. Pearson’s correlation coefficient and independent sample t-test were used for statistical analysis of data. The findings indicated that there was a significant positive correlation between loneliness and psychological distress among young adults. There was no significant difference between loneliness and psychological distress among males and females. Implications and suggestions for future research are discussed.
Automatic Thoughts and Aggression among Adolescents
Authors: Suresh Swathi Mary , Rose Ms. Shruthi
Published: May 2023

Abstract: The purpose of the present study is to assess the role of automatic thoughts on adolescents aggression. The study also assesses whether there are significant difference in gender with respect to aggression. A sample of 100 young adults (50 males, 50 females) aged between 15-22 years participated in the study. The Buss-Perry Aggression Questionnaire (BPAQ) by Drs. Arnold Buss and Robert Perry and the Automatic Thought Questionnaire 30 (ATQ 30) by Steven D. Hollon and Phillip C. Kendall were used to measure the variables in the study. The data were statistically analyzed using the independent sample t-test and Pearson's correlation coefficient. According to the results, aggression and automatic thinking are significantly positively correlated. Aggression in males and females does not significantly differ based on gender.
Object Detection using Salesforce
Authors: S Mahalingam. , I Jayasuriya. , V Nantheeskumar. , K Santhosh.
Published: May 2023

Abstract: Our Project deals with integrating an object detection API with Salesforce, it is a popular customer relationship management (CRM) platform. Object detection APIs can help automate tasks, extract data from images, and enhance the customer experience, which can lead to increased productivity, improved analysis. The integration process involves choosing an object detection API, obtaining necessary credentials, determining how to use the API within Salesforce, connecting to the API using Salesforce APIs, implementing code to handle API response, and thoroughly testing the integration
Utilizing Deep Learning to Detect Objects in Real Time
Authors: V Annapoorani , S Ananth , N Pradeep
Published: May 2023

Abstract: Computer vision is related to object detection. Detecting instances of objects in images and videos is made possible by object detection. It recognizes the component of Pictures rather than conventional article recognition techniques and produces an keen comprehension of pictures very much like human vision works. In this paper, We restored starts the concise presentation of profound learning and item discovery system like Convolutional Brain Network (CNN), Repetitive brain network (RNN), quicker RNN, You just look once (Consequences be damned). After that, we concentrate on the modifications to our object detection architectures that we have proposed. In images, the conventional model can identify a small object. We have a few changes to the model. The method we propose yields the correct result precisely.
Gallium Oxide Nanostructures for Wastewater Treatment: Photocatalytic Degradation of Methyl Orange
Authors: Das Uday
Published: May 2023

Abstract: In recent years, various fabrication methods of photocatalytic materials have been developed for photo degradation of organic and inorganic pollutants from consumable resources. Particularly, inorganic semiconductor nanomaterials have been considered as most promising agents for photocatalytic applications due to their remarkable physical and chemical properties with large effective surface area, and a variety of morphologies, such as nanorods, cubes, spheres and flowers, synthesized by cost effective chemical route.
Outbreak Prediction System using Machine Learning
Authors: Yerlekar Prof. Ashwini , Suralkar Pranav
Published: May 2023

Abstract: Outbreaks have significant social and political impacts such as clashes between nations, population displacement, and increased social tension and discrimination. The work proposes to help in the process of detecting the outbreak and finding the illness using data collected from verified medical professionals and using machine learning algorithm design tree to analysis data collected to identify communities which are in most danger of the outbreak. Thus the system helps to predict and monitor outbreak scenarios.
Revolutionizing Alzheimer’s Disease Diagnosis using Deep Learning Approach
Authors: A Arsah , R Karolin Kiruba , I Kishan , C Neekitha , M Padmapriya
Published: May 2023

Abstract: Disorders of the brain are one of the most difficult diseases to cure because of their fragility, the difficulty of performing procedures, and the high costs. On the other hand, the surgery itself does not have to be effective because the results are uncertain. Adults who have hypertension, one of the most common brain illnesses, may have different degrees of memory problems and forgetfulness. Depending on each patient's situation. For these reasons, it's crucial to define memory loss, determine the patient's level of decline, and determine his brain MRI scans are used to identify Alzheimer's disease. In this project, we discuss methods and approaches for diagnosing Alzheimer's disease using deep learning. The suggested approach is utilized to enhance patient care, lower expenses, and enable quick and accurate analysis in sizable investigations. Alzheimer's disease is a progressive neurodegenerative disorder that affects millions of people worldwide. Early detection of the disease can improve patient outcomes, and brain MRI scans have shown promise as a tool for detecting Alzheimer's disease in its early stages. In recent years, deep learning algorithms, such as convolutional neural networks (CNNs), have been increasingly used in Alzheimer's disease analysis from brain MRI scans. This paper proposes a CNN-based system for Alzheimer's disease analysis from brain MRI scans. The proposed system involves several steps, including data preprocessing, feature extraction, training the CNN model, and evaluating its performance on a test set. The results demonstrate the effectiveness of the proposed CNN-based system in accurately detecting Alzheimer's disease from brain MRI scans. The proposed system has the potential to improve early detection and monitoring of Alzheimer's disease, leading to improved patient outcomes.
Smart Dustbin
Authors: Shukla Priyank , Asthana Ritul , Prakash Siddhant , Trivedi Shikhar , Rawat Archit
Published: May 2023

Abstract: Solid waste generation has been increased in recent times. The concept of sustainable development is really important for co-existence of biosphere and human civilization. Solid waste management is a major issue toward global sustainability crises. An effective mechanism is needed to tackle this problem and to bring a change to the society. Way to sustainability is an efficient use of technology to bring a change to global environmental issues
Developing STEM students’ worksheet to improve students' creative thinking ability
Authors: Pasaribu Khairunnisa , Khairuna K. , Adlini Miza Nina , Abrori Fadhlan Muchlas
Published: May 2023

Changes in the learning paradigm that prioritizes the optimization of creative thinking skills require a lot of consistent innovation and development. This study aims to develop students' worksheets based on STEM on viruses. This development research uses a 4D model by Thiagarajan. The instruments used in this study included interview sheets, validation sheets for content experts and media experts, questionnaires for biology teacher responses, and questionnaires for student responses, as well as tests. Product effectiveness on students' creative thinking skills was carried out using a pretest-posttest design and analyzed using the N-gain calculation. The results showed that the STEM-based students' worksheets on the Virus material that was developed received an assessment of 98% from content experts and 87% from media experts with very valid criteria. The responses of teachers and students were 93.3% and 90% respectively with very practical criteria. The developed STEM-based students' worksheets are also effective in increasing students' creative thinking skills by 0.75 with moderate criteria. These results indicate that STEM-based students' worksheets are appropriate for use in learning to improve students' creative thinking abilities.
Revitalização da pele pós mastectomia: Um relato de caso
Authors: Peres Paines Gabrielle , Brollo Berni Eduarda , Foletto Pivetta Hedioneia Maria
Published: May 2023

Introdução: O tratamento do câncer de mama (CA) ocasiona experiências de vida muitas vezes negativas e traumatizantes. A retirada da mama afeta diretamente a autoestima e a autoimagem corporal, sendo que a reconstrução com prótese de silicone pode melhorar a autoconfiança, funcionalidade e qualidade de vida de mulheres submetidas à mastectomia radical. Entretanto, a taxa de complicações de cirurgias de reconstrução varia em sua incidência considerando diversos fatores, e com isso, a retirada da prótese se faz necessária. A perda da prótese, como consequência, consiste em mais um evento traumático para a mulher, pois cada vez mais formam-se fibroses e aderências que implicam em menor funcionalidade e menos tecido viável para um re-protetização. Objetivo: Analisar os efeitos da fisioterapia sobre revitalização da pele pós mastectomia radical. Metodologia: Relato de caso de paciente com 50 anos, diagnóstico de CA de mama esquerda. Por complicações pós-operatórias evoluiu para a retirada da prótese. Na avaliação fisioterapêutica identificou-se aderência da pele na parede torácica, pele fina, friável e mamilo desviado da linha média. O tratamento fisioterapêutico estabelecido constou de fotobiomodulação com Laser 660nm, associado a cinesioterapia ativa de membros superiores, terapia manual e ventosaterapia em bordos da cicatriz cirúrgica e regiões de aderência da pele à parede torácica. Resultados:  Observou-se melhora da elasticidade da pele com formação de prega cutânea e melhora da aparência da mesma, aumento da espessura e vitalidade da pele e mamilo mais centralizado. Conclusão: A fisioterapia com a utilização da fotobiomodulação associada à ventosaterapia mostrou-se eficaz no tratamento de revitalização e funcionalidade da pele pós mastectomia radical.
Dayah Entrepreneur dan Budaya Akademis Santri: Pendidikan Islam dan Pembelajaran Bahasa Arab di Dayah Darussalam SMK ASD Bireuen, Aceh
Authors: Fikri Mumtazul
Published: May 2023

Dayah is a progressive educational institution in Aceh that constantly to adapt and adjust to developments in education. Lately, the development of dayah education is entrepreneurship with its peculiarities and characteristics. This research aims to determine the model of Islamic education and Arabic Language learning in Dayah Entrepreneur Darussalam SMK ASD. This research is a qualitative approach with the case study method. Data collection process using interviews, observation and documentation. The research subject is the dayah leader, vice headmaster of curriculum, Arabic teacher and students. Analysis of the research data using data analysis techniques Miles and Huberman with data collection, data reduction, data presentation and drawing conclusions. The results of the reseacrh show that the application of Islamic education in Dayah Entrepreneur Darussalam uses an integrative curriculum. The collaboration and integration between the Vocational High School curriculum into the Islamic boarding school education curriculum. The curriculum integration model used is the across several disciplinary integration model. Learning Arabic at Dayah Entrepreneur Darussalam SMK ASD uses a boarding school educational model with the characteristics of a conservative boarding school. The Arabic material presented is integrated into the teaching of the kitab kuning text. The problems of learning Arabic at Dayah Entrepreneur Darussalam ASD Vocational School, lack of native speakers teaching Arabic, lack of focus in daily Arabic conversation (muhadatsah) and students unable to read the kitab kuning in learning Arabic. The solution is published a concise edition of the Matan Taqrib kitab for the convenience of students to understand Fiqh as well as Arabic. Launched Arabic and English week with rewards and punishments and inviting teachers from Middle East alumni as substitutes for native Arabic speakers.
Indigenous Wisdom of Ayurvedic Drugs to Treat Liver Disorders-Review Article
Authors: Maheshwari Devanshi , Rathi Bharat , Rathi Renu , Shinde Aditi R.
Published: May 2023

The liver, a vital organ in the body, synthesizes hormones, decomposes RBC in the blood, and regulates glycogen storage. The liver also performs detoxification and is the primary site for drug metabolism. Therefore, hepatoprotective medications are necessary to keep the liver in good health. Ayurvedic drugs are widely used as hepatoprotective agents. The study aims to review the Yakrit (liver) concept in Ayurvedic literature, identify hepatoprotective plants from classical Ayurveda texts, and understand their mode of action on the liver based on existing scientific evidence. The classical Ayurveda literature and electronic databases such as Google Scholar, PubMed, Web of Science, and ARP were searched until October 2022 to find relevant studies using MESH terms. The search of classical Ayurveda texts showed several herbal sources that are advocated for use in liver disorders. The in vivo studies for these plants showed that seven protected the liver from CCl4-induced hepatic damage. Furthermore, the levels of liver enzymes were reduced, and there was evidence of reversal of fatty changes in the liver in mice fed with a high-fat diet. One of the essential organs that aid in sustaining bodily health is the liver. Some plants have been endowed by nature with the ability to treat, prevent, and cure liver disorders while causing fewer negative effects. Herb-based Ayurveda drugs can be a potent source of hepatoprotective agents, though detailed studies need to be conducted to generate more substantial evidence.
Sistema Nacional Integrado de Salud: Una aproximación al cuidado de la salud en Uruguay
Authors: Rodríguez Facal Ana Mariela
Published: May 2023

El objetivo del presente trabajo es realizar una descripción de los avances en la implantación de la reforma del sistema de salud uruguayo, a más de quince años de su implantación; mediante un análisis bibliográfico, considerando que las reformas de los sistemas de salud son constantes aproximaciones mediante ensayo y error. En el presente caso, se entiende que se debe seguir trabajando en la sostenibilidad económico-financiera del sistema, la complementación entre instituciones y en determinar cuál es la unidad básica de negocio para este mercado en Uruguay.
Propuesta de Evaluación de Gestión de Residuos y el impacto ambiental de la atención de los servicios de salud en el Área de Salud de Curridabat de la Caja Costarricense del Seguro Social en el 2023-2024
Authors: Murillo Rodríguez Ericka Carolina
Published: May 2023

RESUMEN: Los efectos de los servicios de la salud son imprescindibles para la salud pública ya que están produciendo serios impactos en el presupuesto de los hospitales, cada vez más, se requiere mayor inversión económica para atender pacientes con enfermedades asociadas a la contaminación ambiental y aunque las acciones son para proteger y restaurar la salud, la generación de los desechos y subproductos que se generan son considerables (OMS, 2015). En tal sentido, el sector salud puede tener un rol importante en la mitigación de la generación de los residuos de la atención. Por lo que el objetivo que se plantea es establecer el impacto ambiental de la gestión de los residuos de la atención sanitaria en el Área de Salud de Curridabat entre los años 2023-2024.

Se realizará un estudio observacional descriptivo longitudinal utilizando una muestra a conveniencia de un área de salud de la institución Caja Costarricense del Seguro Social; en este caso pertenecientes a Curridabat 2, incluyendo las 5 sedes de EBAIS, Servicios de Odontología, Farmacia, CEYE y oficinas administrativas. La información se recogerá directamente por los investigadores o intermediarios del centro de salud en los días de recolección de residuos sólidos comunes y  reciclaje mediante la aplicación de los documentos de Protocolos de Evaluación elaborado por el DIGECA del MINAE. Se realizará la matriz de desempeño ambiental con el cálculo de los indicadores correspondientes para la zona de estudio. Se hará la correlación con los datos de las consultas brindadas por el centro de salud y/o servicios realizados. Se realizará el análisis del impacto ambiental de los residuos recolectados, así como la evaluación de los conocimientos y prácticas de los funcionarios del área.
Scientific writing for publication: A transdisciplinary approach
Authors: Link Stephanie
Published: May 2023

This book presents a genre-based approach emphasizing strategies that derive from a field of research focusing on strengthening the language skills of multilingual English speakers.
The impact of COVID-19 on the corporate social responsibility reporting of listed corporations: A case of South Pacific Stock Exchange
Authors: Tanzil Sheikh Ali
Published: May 2023

This research paper aims to investigate the impact of COVID-19 on corporate social responsibility (CSR) reporting of listed entities in the South Pacific Stock Exchange (SPX) through a content analysis of annual reports of selected companies listed on the SPX over two years, using a mixed approach of qualitative and quantitative methods, including a case study methodology with archival data and word count analysis. The study found that the pandemic has significantly affected CSR reporting, with companies focusing on societal needs related to the crisis rather than traditional CSR activities. It highlights the need for companies to be more transparent in their CSR reporting, especially during a crisis such as COVID-19, to build trust and confidence with stakeholders. The research contributes to the growing body of knowledge on the impact of the pandemic on businesses globally, informed by legitimacy theory consistent with Suchman’s (1995) findings.
Social Relation of Production and Conflict of Economic Interests in Smallholder Oil Palm Plantations: A Case Study of Sintang District, West Kalimantan
Authors: Borni Kurniawan Kharis Fadlan , Dharmawan Arya Hadi , Sumantri Titik , Maksum Mohammad
Published: May 2023

An agricultural partnership is one of the ways adopted by oil palm plantation smallholders to survive and be sustainable in the face of global competition. The agricultural partnership that is based on a contract agreement is also aimed at maintaining the welfare of the involved smallholders. Partnership in agricultural production is part of the management system or mode of economic production agreed upon by both large-scale companies and smallholders. An unbalanced arrangement sometimes occurs due to the power dominance of large-scale company interests that leads to unfair relationships in the partnership between smallholders and large-scale corporations. This study used a qualitative research method with a case study as the main approach. By taking the case of the agricultural partnership of oil palm plantation smallholders in Perembang Village and Begori Village, Regency of Sintang of West Kalimantan, this study found four typologies of social agricultural production relations, namely asymmetric partnership, exploitative partnership, distrust partnership, and forced partnership.
Lipopolysaccharides protect Mesenchymal Stem Cell against Cardiac Ischemia-reperfusion Injury by HMGB1/STAT3 signaling
Authors: Xu Bing , Wen Jing-Yi , Peng Hui-Xi , Wang Dan , Wen Zhi-Min , Liu Yu-Tong , Qu Jian , Cui Hong-Xuan , Wang Yu-Ying , Du Yan-Lin , Wang Ting , Geng Cong
Published: May 2023

Myocardial ischemia-reperfusion (I/R) is a serious and irreversible
injury. Bone marrow-derived mesenchymal stem cells (MSCs) is considered
to be a potential therapy for I/R injury due to the paracrine effects.
High-mobility group box 1 (HMGB1) is a novel mediator in MSC and
regulates the response of inflammation injury. Signal Transduction and
Transcription Activator 3 (STAT3) is a critical transcription factor and
important for release of paracrine factors. However, the relationship
between HMGB1 and STAT3 in paracrine effect of MSC remains unknown.
In vitro, Hypoxia/Reoxygenation injury model was established by
AnaeroPack System and examined by Annexin V flow cytometry, CCK8 assay
and morphology observation. Detection of apoptotic proteins and protein
expression of HMGB1 and STAT3 by Western blot. The conditioned medium of
MSC with or without LPS pretreatment was cocultured with H9c2 cells for
24h before hypoxia treatment and MSC showed obvious cardiomyocytes
protect role, as evidence by decreased apoptosis rate and improved cells
viability, and LPS pretreated MSC exhibited better protect role than
untreated MSC. However, such effect was abolished in HMGB1 deficiency
group, silencing HMGB1 decreased the secretion of VEGF, HGF, IGF, cell
viability, and the expression of STAT3. Furthermore, STAT3 silence
attenuated the protective effect of LPS in MSC. Collectively, these
findings suggested that LPS improved MSC-mediated cardiomyocytes
protection by HMGB1/STAT3 signaling.
A transformerless Z-Source photovoltaic grid-connected inverter with coupled inductor coil
Authors: Dai Yunzhong , Zhang Huaiyu
Published: May 2023

The quasi-Z-source H-bridge grid-connected inverter (QHGCI) is well
known with its advantages of the void of shoot-through problem and the
high DC-voltage utilization. But the existence of the common-mode
leakage current in the power frequency cycle, lower power density and
higher thermal stress makes it hardly applicable to the grid-penetrating
application. Thus with a purpose to conquer the problem relating to the
QHGCI, an innovative transformerless Z-Source photovoltaic
grid-connected inverter with coupled inductor coil (TZPGCI-CIC) is
proposed. The circuitry topology and an unipolar SPWM strategy are
firstly introduced in short. And thereafter the common-mode voltage in
the whole working process is derived and evaluated through the detailed
operating mode analysis, in which a constant value of it has been
theoretically revealed. Lastly, a prototype platform of TZPGCI-CIC is
setup and its good performance on leakage current suppression, lower
thermal stress are validated with the experimental results.
Design of A Compact Multiband Microstrip Antenna for WiMAX, WLAN and X-Band Applications
Authors: Suthar Akansha , Agrawal Navneet
Published: May 2023

In this research work, a compact triple-band antenna for WiMAX, WLAN and
X-band applications is presented. The proposed antenna has compact size
of 18x21.3mm2. The miniaturization of 52.10% is achieved compared with
the conventional antenna. For achieving compactness and multiple
frequency operation a square patch is loaded with inverted U-shaped
slots and partial ground is used and can resonates at 3.26 GHz, 5.95 GHz
and 8.83 GHz with a return loss of -29.15 dB, -43.40 dB, -41.14 dB
respectively with highest gain of 2.69 dB. The proposed multiband
structure yields good impedance matching, acceptable gain, and wide
bandwidth.
Timosaponin BⅡ alleviates DSS-induced ulcerative colitis in mice by inhibiting NLRP3
Authors: Feng Meng , Zhou Yingya , Gao Zhenyv , Liu Changhui
Published: May 2023

Background and Purpose Inhibition of NLRP3 inflammasome plays a critical
therapeutic potential in the colonic inflammatory responses. The
Timosaponin BⅡ (TBII) isolated from the traditional Chinese medicine
Anemarrhena asphodeloides has outstanding anti-inflammatory effects in a
variety of diseases. Here, we investigated the protective effects of
TBII against dextran sulfate sodium (DSS)-induced ulcerative colitis in
mice. Experimental Approach Wild-type (WT) and NLRP3 knockout (NLRP3-/-)
mice were applied to evaluate the protective effects of TBII in
DSS-induced mice colitis. The role of TBII in LPS+ATP-induced cell model
was evaluated by inhibiting or overexpressing NLRP3. RNA-seq, ELISA,
western blots, immunofluorescence staining and the expression analysis
by qPCR were performed to examine the alterations of colonic NLRP3
expression in colon tissues and cells, respectively. Key Results In mice
with DSS-induced ulcerative colitis, TBII treatment repaired the
intestinal mucosal barrier and alleviated colonic inflammation. RNA-seq
analysis and levels of protein expression demonstrated that TBII could
prominently inhibit NLRP3 signaling. TBII-mediated NLRP3 inhibition was
associated with the alleviation of intestinal permeability and the
inflammatory response via blocking the communication between epithelial
cells and macrophages. However, pharmacological inhibition of NLRP3 or
NLRP3 overexpression significantly impaired TBII-mediated the
anti-inflammatory effect. Mechanistically, TBII-mediated NLRP3
inhibition may be partially associated with the suppression of NF-κB.
Conclusion and Implications TBII exerted a prominent protective effects
against colitis via impeding the crosstalk between epithelial cells and
macrophages, partially in the NLRP3-mediated the inhibitory mechanism.
These beneficial effects could make TBII as a promising drug for
relieving colitis.
Clinical Strategies and Therapeutics for Human Monkeypox Virus: A Revised Perspective on Recent Outbreaks
Authors: Kandimalla Ramesh , Ghosh Nilanjan , Cahcko Leena , Vallamkondu Jayalakshmi , Banerjee Tanmoy , singh Birbal , Kalra Rajkumar Singh , Bhatti Jasvinder Singh , Dewanjee Saikat
Published: May 2023

An enveloped double-stranded DNA monkeypox virus (MPXV) is a causative
agent of zoonotic viral disease viz. Human monkeypox (HMPX). MPXV
belongs to the genus Orthopoxviridae, a family of notorious smallpox
viruses, and so it shares similar clinical pathophysiological features.
The recent multi-country HMPX outbreak (May 2022 onwards) is recognized
as an emerging global public health emergency by WHO, shunting its
endemic status as opined over the past few decades. Re-emergence of HMPX
raises concern to re-assess the present clinical strategy and
therapeutics as its outbreak evolves further. Keeping a check on these
developments, here we provide insights into the HMPX epidemiology,
pathophysiology, and clinical representation. Weighing on its early
prevention, we reviewed the strategies that are being enrolled for HMPX
diagnosis. In the line of expanded MPXV prevalence, we further reviewed
its clinical management and the diverse employed preventive/ therapeutic
strategies, including vaccine (JYNNEOS, ACAM2000, VIGIV) and antiviral
drugs/inhibitors (Tecovirimat, Cidofovir, Brincidofovir). Taken
together, with a revised perspective of HMPX re-emergence, the present
report summarizes new knowledge on its prevalence, pathology, and
prevention strategies.
Overcoming the constraints of competitive clientelism? Explaining the success of Ghana's Poorest Region in Reducing Maternal Mortality.
Authors: ABDULAI ABDUL-GAFARU
Published: May 2023

Maternal mortality remains a health challenge that many developing
countries struggle to address. Drawing on 64 key informant interviews,
this article shows how Ghana’s most impoverished administrative region,
the Upper East, emerged as a bureaucratic ‘pocket of effectiveness’ in
reducing maternal mortality in a context where national political
settlement dynamics are undermining progress in improving maternal
health. At the national level, Ghana’s progress in reducing maternal
mortality has been disappointing because public investments are
disproportionately directed to reforms that contribute to the short-term
political survival of ruling elites. Competitive electoral pressures
have contributed to greater elite commitment towards health sector
investments with visual impact, while weakening elite incentives for
dedicating resources to interventions that are necessary for enhancing
the quality of health. In the Upper East Region, the rapid
reduction in maternal mortality in recent years has been driven by a
hybrid form of accountability that combines top-down pressures from the
regional health directorate with horizontal forms of accountability that
result in a competitive spirit among health workers. These findings show
that even in contexts where resources are limited, the capacity of
sub-national leaders in devising local solutions to local problems can
lead to improved performance of health systems at the sub-national
level. The findings also suggest the need for academic debates to go
beyond the binary distinctions regarding the usefulness of top-down
versus bottom-up accountability measures and focus on building effective
and legitimate forms of accountability that run both top-down and
bottom-up when seeking to improve health service delivery.
­­­Comprehensive overview on 2022 human monkeypox outbreak and its pathology, prevention, and treatment: A strategy for disease control
Authors: Rana Rashmi , H Yashavarddhan M , Bohra Deepika , Tuli Hardeep Singh , Ranjan Vivek , Rana Devinder Singh , Ganguly Nirmal Kumar
Published: May 2023

As the COVID-19 pandemic scare fades in early 2022, governments
throughout the world are now battling a fear of monkeypox outbreaks in
various regions. The human monkeypox virus is a double-strand DNA virus
that was first discovered in Africa. The 2022 monkeypox virus can spread
from person to person and through infected animals. Nevertheless, the
host or carrier for the same has not yet been cleared. The relatively
low transmission rate has barred it from attracting attention on a
global scale. However, as cases increase, the 2022 monkeypox virus
creates a panic. Around 103 countries were affected due to this virus
till September 2022. There is currently no global preventive or cure
available for this virus. Only two vaccinations that were previously
authorized for smallpox are licensed for this virus. Similarly, there is
only one drug available for therapy. The article will give comprehensive
knowledge regarding available virus epidemiology, morphology, immune
invasion prevention, and treatment which help the researcher to come
forward and develop a strategy for the disease prevalence.
BIBLIOMETRIC ANALYSIS AND CLINICAL STUDY OF DYSPHAGIA IN HEAD-AND-NECK CANCER
Authors: Fakhriani Rizka , Ulfa Maria , Surono Agus
Published: May 2023

Background: Dysphagia is the inability to swallow liquid or
solid food due to structural or functional problems. This study aims to
help people learn more about dysphagia in head and neck cancer.
Design: This research used the PRISMA technique and
bibliometric indices to navigate the results of global publication
trends regarding dysphagia in head and neck cancer for five years from
2018 to 2022. Furthermore, the paper creates a graphical picture of the
bibliographic material by mapping keywords and countries with
bibliographic analysis using VOSviewer and NVIVO 12 Plus.
Results: A distinct publishing trend was seen in statistics
from 137 scientific journal articles published between 2018 and 2022.
The United States had the most Scopus-indexed scientific research
publications, and 2020 was the year that produced the most publications.
The VOSviewer results demonstrated four clusters. According to the NVIVO
12-plus application, this topic was elated to five issues: therapy,
neck, radiotherapy, carcinoma, and outcome. Conclusions:
Dysphagia in head and neck cancer should not be overlooked, as it may be
close to 60% to 70%. This may have both clinical and research
implications. We suggest other researchers can develop other topics that
we had presented regarding a systematic and comprehensive summary of
research on dysphagia in head and neck cancer.
Phytochemical analysis and biological activities of Salvia candidissima subsp. candidissima mericarps
Authors: Guzel Kara , Oksuz Zehra , Gungor Uras , Belveren Samet , Kahraman Ahmet
Published: May 2023

The sterol, amino acid, mineral, total phenolic, and total flavonoid
contents, and the antioxidant, antimicrobial, and antibiofilm activities of
Salvia candidissima subsp. candidissima mericarps were investigated. The
mericarps were collected in the province of Bayburt, Turkey. Gas
chromatography was used for sterol analysis, Prominence ultra-fast liquid
chromatography for amino acid analysis, and ICPMS for mineral analysis.
Folin-Ciocalteu, Al(NO3)3, and DPPH radical scavenging activity assays were
performed on ethanol extracts of the mericarps to evaluate the total
phenolic and flavonoid contents, and antioxidant potential, respectively.
The ethanol and hexane extracts of the mericarps were tested for their
antimicrobial activity against seven bacterial and three fungal strains
using the microdilution method and for antibiofilm activity against
Pseudomonas aeruginosa biofilm using the crystal violet staining method. The
sterol, amino acid, and mineral contents and antibiofilm activity of the
mericarps were studied for the first time. The most abundant components of
the mericarps are determined as ?-sitosterol (69.8%), glutamic acid (4895
mg/100 g), and potassium (11474 ?g/g). The results of total phenolic and
flavonoid contents and DPPH free radical scavenging activity were 3.47 ?g
GAE/mg extract, 0.35 ?g QE/mg extract, and 79.79%, respectively. Both of the
tested extracts exhibited antimicrobial activity against all the tested
microorganisms, however, the efficiency of the extracts was not as strong as
the reference drugs ampicillin and fluconazole. While both extracts were
effective in preventing biofilm formation, the ethanol extract was found to
be more effective than the hexane extract in preformed biofilm inhibition.
In conclusion, S. candidissima subsp. candidissima mericarps have good
nutritional potential with high amounts of amino acids, sterols (especially
?-sitosterol), minerals, and phenolics and flavonoids. Additionally, our
findings provide important preliminary data for the literature in terms of
the antibiofilm activity of Salvia candidissima subsp. candidissima
mericarps.
New records and noteworthy data of plants, algae and fungi in SE Europe and adjacent regions, 13
Authors: Sabovljevic Marko , Tomovic Gordana , Kunev Georgi , Taşkın Hatıra , Bozok Fuat , Sovran Sanja , Knezevic Ana , Cimerman Zan , Strgulc-Krajsek Simona , Kuzmanovic Nevena , Lazarevic Predrag , Assyov Boris , Stoykov Dimitar , Szeląg Zbigniew , Vladimirov Vladimir , Rakonjac Aleksandra , Simic Snezana , Sabovljevic Aneta , Papp Beata , Pantovic Jovana , Stankovic Mihajlo
Published: May 2023

This paper presents new records and noteworthy data on the following taxa in
SE Europe and adjacent regions: brown alga Heribaudiella fluviatilis, red
alga Batrachospermum skujae, saprotrophic fungus Gnomonia
geranii-macrorrhizi, mycorrhizal fungi Amanita alseides and Russula
griseascens, liverwort Ricciocarpos natans, moss Blindia acuta, Leucodon
sciuroides var. morensis and Pseudostereodon procerrimus, monocots Allium
ampeloprasum, Carex ferruginea and Carex limosa and dicots Convolvulus
althaeoides, Fumana aciphylla, Hieracium petrovae, Lamium bifidum subsp.
bifidum and Ranunculus fontanus are given within SE Europe and adjacent
regions.
In the maelstrom of crises: The European Union and the ‘Zeitenwende’
Authors: Gabrisch Hubert
Published: May 2023

This essay aims to promote discussion on fundamental reforms of the European
Union (EU). Its thesis is that the global turning point triggered by
multiple crises affects the entirety of the EU architecture and that reforms
can therefore not be limited to piecemeal reforms in individual areas.
Methodologically, the essay takes an ideology-critical approach with what is
commonly referred to as ?neoliberalism? at its centre. As a result, the
essay draws a Union that gains its own sovereignty through democratic
reforms in decisionmaking.
Where did all the papers go? A bibliometric overview of publications in economics from Serbia
Authors: Stamenkovic Mladen
Published: May 2023

In this paper, we provide a bibliometric overview of publications in
economics by authors with affiliations from Serbia. We use the Web of
Science database, analyse all the articles published from 1996 onwards, and
provide an overview of publications, journals targeted, trends, and the
effects of collaboration. We identify the main topics of interest of the
published papers. To do this, we use bibliographic mapping and provide the
most common terms used in the titles and abstracts of the papers, grouped in
clusters. Using these clusters, we present the main interests and focus of
the papers in the dataset. The robustness of the conclusions is obtained by
extending the analysis to another citation database, the SCImago Journal
Rank.