bluuebunny/crossref_metadata_2025 huggingface dataset:
Delay Discounting and Risk Tolerance in Obsessive Compulsive Disorder: Results From the Global OCD Study
Authors: Lempert Karolina M. , Huber Benjamin , Batistuzzo Marcelo C. , Sheshachala Karthik , Hezel Dianne M. , de Joode Niels T. , Marincowitz Clara , Lochner Christine , Stein Dan J. , Narayanaswamy Janardhanan C. , van den Heuvel Odile A. , Wall Melanie , Simpson Helen Blair
Published: November 2024

Although obsessive compulsive disorder (OCD) features maladaptive decision-making, previous research that examined economic decision-making in OCD has yielded inconsistent results. Here, we examined whether unmedicated adults with OCD ( n = 268) differ from healthy control subjects (HCSs; n = 256) on two measures of decision-making about potential rewards: (a) delay discounting, the tendency to prefer rewards sooner rather than later, even if the delayed reward is larger, and (b) risk tolerance, the willingness to gamble for uncertain rewards when the risk is known. Data were collected in Brazil, India, the Netherlands, South Africa, and the United States as part of the Global OCD study. After controlling for age, sex, education, socioeconomic status, IQ, and site, individuals with OCD did not differ from HCSs in either delay discounting or risk tolerance. However, patients with OCD who reported more anxiety and depression showed higher delay discounting, or a relative preference for immediate rewards.
Apparent lncRNAs involvement in pathogenesis of endometriosis
Authors: Kwas Katarzyna , Szubert Maria , Wilczyński Jacek
Published: November 2024

Endometriosis is an estrogen-dependent, debilitating gynecologic disease impacting millions of women globally. One of the main characteristics of this benign condition is the presence of endometrial-like tissue outside the uterus, causing dysmenorrhea, chronic pelvic pain, and infertility. However, despite many reports on the origin and molecular pathogenesis of endometriosis, the etiology of this disease has not been fully explored yet. Recently, significant attention has been paid to long noncoding RNAs (lncRNAs). Numerous studies focused on exploring the association between lncRNAs and the progression of various human diseases. LncRNAs function as competing endogenous RNAs (ceRNAs) interacting with microRNAs as a “sponge” to regulate cell functions. According to multiple studies, lncRNAs seem to have the potential as markers for diagnosing, and monitoring progression and staging in endometriosis. In this review, we summarized the lncRNAs that were found to influence the pathogenesis of endometriosis. Furthermore, we tried to assess its potential in the process of endometriosis transition from benign through atypical forms, up to EAOC (Endometriosis Associated Ovarian Cancer).
Effect of Platelet-Rich Plasma Injection on the Treatment of Achilles Tendinopathy: A Systematic Review and Meta-analysis
Authors: Ling Samuel Ka-Kin , Mak Clarence Tsz-Kit , Lo Jasmine Pui-Yin , Yung Patrick Shu-Hang
Published: November 2024

Background:

Achilles tendinopathy is a common condition without a reproducible and timely treatment modality. Platelet-rich plasma (PRP) injection has been proposed as an enticing treatment option, but there is no consensus regarding its effectiveness.

Purpose:

To pool the available data and evaluate the evidence of the effect of PRP injections on Achilles tendinopathy.

Study Design:

Systematic review; Level of evidence, 1.

Methods:

This review was conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. CINAHL via EBSCOhost, Cochrane Library, and PubMed databases were searched for randomized controlled trials comparing PRP injection with nonoperative treatment, with the Victorian Institute of Sport Assessment–Achilles (VISA-A) questionnaire score or maximal Achilles tendon (AT) thickness on ultrasound as outcome measures. Risk-of-bias assessment was performed of the included studies, and meta-analyses compared differences in outcome measures between PRP injection and control at the short-term (3-month), intermediate-term (6-month), and long-term (12-month) follow-ups.

Results:

Of 409 publications, 6 publications (N = 422 patients with chronic midportion Achilles tendinopathy) were identified from the literature search. Risk-of-bias assessment revealed 2 studies were low risk, 1 was of some concern, and 3 were high risk of bias. Meta-analysis revealed no significant differences between PRP injection and control at any time point for both VISA-A score (short term: P = .29; intermediate term: P = .42; long term: P = .57) and maximal AT thickness (short term: P = .60; intermediate term: P = .20; long term: P = .55).

Conclusion:

Our review demonstrated that although recent trends have shown an increasing popularity of PRP injection, no solid evidence has been established. The heterogenicity of the tendinopathy pathology and the PRP injection content and methodology should be controlled by better-designed clinical trials. Further research is needed before it should be recommended as a standard treatment.
A systematic review about strategies to reduce kinesiophobia after Anterior Cruciate Ligament Reconstruction (ACLR)
Authors: Serafim TT , Lehmkuhl SL , Andrade A
Published: November 2024

Objectives

Anterior Cruciate Ligament (ACL) injuries are common injuries within sports. While these are common injuries, they are also feared injuries due to the surgical procedure, the long period of rehabilitation and the uncertainty of returning to sport (RTS), with kinesiophobia being one of the main causes that prevent athletes from this RTS. The objective of this systematic review is to verify which strategies can be used and which are effective in reducing kinesiophobia during the rehabilitation of anterior cruciate ligament injuries. A secondary objective is to analyze whether any of these strategies can facilitate RTS.

Methods

This is a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) model. The search was carried out in the databases: PubMed (MEDLINE), Web of Science, ScienceDirect (Elsevier) and PsycINFO (APA) and was closed on December 16, 2023 with the following terms: "Anterior Cruciate Ligament" AND “ACL injur *” OR kinesiophobia OR Fear OR Psychological AND Therapy OR Rehabilitation OR Treatment.

Results

Eight clinical trials were selected for data analysis. In total, 396 individuals were evaluated with a mean age of 16.0±5.0 years to 35.0±11.9 years. The most used questionnaires to assess kinesiophobia were the Tampa Scale for Kinesiophobia (TSK) and the Anterior Cruciate Ligament – Return to Sport Index (ACL-RSI). Most studies showed the effectiveness of interventions in reducing kinesiophobia. Other outcomes were also evaluated and were found to be favorable for the intervention groups (IG), compared to the control groups (CG).

Conclusion

Education about treatment, progressive physical training and variation in the post anterior cruciate ligament reconstruction rehabilitation process prove to be an effective alternative in reducing kinesiophobia and improving knee function.
Adipose tissue harvesting for microfragmented adipose tissue injection: A pilot study to evaluate safety and learning curve for orthopedic surgeons
Authors: Varone BB , Leite CBG , Giglio PN , Kubota BS , Gobbi RG , Demange MK
Published: November 2024

Objectives

The objective of this study is to compare the complication rate between plastic and orthopedics surgeons on harvesting adipose tissue for osteoarthritic knee mFAT injections.

Methods

We evaluated patients with knee osteoarthritis who were submitted to a one-stage procedure that included the harvesting of abdominal adipose fat tissue, the processing of the adipose tissue using a single-use device Lipogems®, and the injection of the processed micro fragmented adipose tissue (mFAT) into the knee. One group of patients had the adipose tissue harvested by a plastic surgeon and the other group had the procedure performed by a recently trained orthopedic surgeon. We compared the adverse effects, minor and major complications related to the adipose tissue harvesting during the procedure and after 15 days.

Results

Both groups showed no major complications such as fat embolism, thromboembolic event, abdominal perforation, wound infection, dehiscence or cosmetic changes. Minor complications, such as abdominal discomfort during the harvesting showed no statistical difference. Adverse effects such as abdominal ecchymosis and abdominal discomfort after the procedure were prevalent in both groups and were solved within 15 days of the procedure

Conclusion

For small adipose tissue volume harvesting, our study supports that low complication rates can be achieved by an orthopedic surgeon with adequate training.
Magnetic Resonance Imaging of the knee anteromedial quadrant
Authors: Jorge PB , Jorge RB , Oliveira DE , Helito CP , Sato FT , Silva IP
Published: November 2024

Objectives

This study aims to evaluate the possibility of characterizing an extra-articular thickening in the knee anteromedial quadrant in routine MRI scans, the Anterior Oblique Ligament (AOL).

Methods

Firstly, in a pilot study, for a better understanding of this extra-articular thickening trajectory in MRI, polytetrafluoroethylene (PTFE) tubes were attached to the ligament structure topography in two dissected pieces. Afterward, 100 knee MRI studies were randomly selected from our database, and 97 met the inclusion criteria. Two musculoskeletal radiologists interpreted the exams separately. Both had previously studied the ligament in the cadaveric knee MRI with the PTFE tube.

Results

The intraobserver and interobserver agreement for the ligament identification was calculated using Cohen’s Kappa coefficient. The first radiologist identified the structure in 41 of the 97 scans (42.2%), and the second radiologist in 38 scans (39.2%). The interobserver agreement was substantial, with a Kappa of 0.68 and an agreement of 84.5%. The results suggest that this extra-articular thickening, recently called Anterior Oblique Ligament (AOL) in the literature, is a structure that can be frequently visualized on MRI scans with a high level of interobserver agreement in a relatively large number of exams.

Conclusion

Therefore, this study indicates that MRI is a promising method for evaluating this anteromedial thickening, and it may be used for future studies of the Anterior Oblique Ligament.
Patients with knee hyperextension who regained preoperative range of motion after ACL reconstruction have worse knee stability but better subjective outcomes than patients who did not regained preoperative range of motion
Authors: Helito CP
Published: November 2024

Objectives

To evaluate patients submitted to ACL reconstruction with preoperative hyperextension and compare patients who recovered the entire range of motion with patients who recovered full extension but not hyperextension.

Methods

Patients submitted to surgery from June 2013 to June 2021 were evaluated. Patients aged 18 to 60 years with acute or chronic ACL injuries submitted to anatomical ACL reconstruction with a single bundle and any graft with at least 24 months of follow-up were included. The following data were collected: age, sex, time from injury to surgery, passive knee hyperextension, pre-and postoperative KT-1000 arthrometer laxity and pivot-shift, associated meniscal injury and treatment (meniscectomy or repair), type of graft used, intra-articular graft diameter, associated extra-articular procedure, follow-up time, and postoperative Lysholm Knee Scoring Scale and International Knee Documentation Committee (IKDC) subjective scores.

Results

Among 225 patients evaluated, 48 (21.3%) did not recover preoperative hyperextension, and 177 recovered range of motion. Regarding the pre-and intraoperative variables, there was no difference between the groups, except that who did not recover hyperextension had a larger diameter graft than patients who recovered hyperextension (8.7 ± 0.7 vs. 8.3 ± 0.7; p = 0.018). Regarding the postoperative variables evaluated, patients who recovered the preoperative hyperextension showed improvement on all scales evaluated compared to patients who did not recover the range of motion. However, patients who recovered hyperextension showed more laxity on physical examination, measured by the KT-1000 and the pivot-shift.

Conclusion

Patients with knee hyperextension greater than 5 degrees who regained preoperative range of motion after ACL reconstruction have worse knee stability according to KT-1000 and pivot-shift tests than patients who regained full extension but not hyperextension. However, patients who recover full range of motion show improvement on all subjective function scales.
Evaluation of KLIC and CRIME80 scores for analysis of the risk of failure of the debridement, antibiotics and implant retention procedure in acute postoperative periprosthetic joint infections of the knee
Authors: Oliveira Filho NG , Mozella AP , De Oliveira ACL , Corrêa VK
Published: November 2024

Objectives

The primary objective of the study was to evaluate the efficiency of KLIC and CRIME80 scores in assessing the risk of failure of the Debridement, Antibiotics and Implant Retention (DAIR) procedure for the treatment of acute postoperative periprosthetic joint infection after total knee arthroplasty (TKA). Secondary objectives included determining the failure rate of DAIR and identifying factors related to DAIR treatment failure.

Methods

A retrospective study was conducted with patients undergoing DAIR within 30 days post-TKA or TKA revision at a specialized SUS hospital for high-complexity orthopedic surgeries. Patient records were evaluated to collect the necessary information for score assessment. Procedure failures were considered if re-intervention was required within 60 days, death occurred within 60 days, or if suppressive antibiotic therapy was needed.

Results

The study included 17 patients undergoing the DAIR procedure. 52% of infections were caused by Staphylococcus aureus, and 29% occurred after revision surgery. Six (35%) patients experienced DAIR failure, and the mortality rate was 11%. Patients who failed had a higher score on the KLIC score (p<0.0001). Regarding the CRIME80 score, only 33% of those with a score of less than 3 experienced procedure failure. Results also showed that for patients with a KLIC score between 2,5 and 5, the presence of a comorbidity or risk factor resulted in DAIR failure. Additionally, 100% of patients with chronic kidney disease experienced treatment failure, with 66% of them progressing to death.

Conclusion

Our results demonstrated that the KLIC and CRIME80 scores proved to be effective methods in predicting the likelihood of failure in the treatment of acute postoperative periprosthetic joint infection with DARI and patients in intermediate KLIC groups with comorbidities are subject to a higher chance of failure.
Evaluation of the peroneus longus tendon as an autologous graft in knee surgery
Authors: De Oliveira DE , Canuto SMG , De Padua VBC , Horita MM , Malpaga JMD , Jorge PB
Published: November 2024

Objectives

Our hypothesis is that the peroneus longus (PL) is a great option for ligament reconstruction in the knee, and therefore the objective of the study is to determine if the use of this graft is safe and does not cause secondary damage to the harvested area.

Methods

A prospective study was conducted between April 2019 and September 2022. Patients who underwent any type of knee ligament reconstruction using the PL or just the anterior half (AHPL) as grafts were followed up. These patients were evaluated according to the Tegner–Lysholm score and the International Knee Documentation Committee (IKDC) guidelines for functional evaluation of the knee and the American Orthopedic Foot and Ankle Score (AOFAS) and the Foot and Ankle Disability Index (FADI) for the functional evaluation of the ankle.

Results

Most patients had an increase in the IKDC score, Tegner–Lysholm score, AOFAS and FADI regardless of the graft used in the surgical procedure, with mean values at the 24-month follow-up of, respectively, 99.02± 1.02, 98.69± 1.08, 99.92± 0.27, and 99.92± 0.27 for those with PL grafts and 99.31± 0.54, 98.88± 0.95, 100± 0.00, and 100± 0.00 for those with AHPL grafts. The differences in the scores between the two graft groups during each of the follow-up periods were significant (P = 0.001).

Conclusion

The use of the peroneus longus tendon as a graft in knee surgeries was shown to be adequate for achieving good knee functional results.
Unicompartimental Knee Arthroplasty In Patients With or Without Patellofemoral Arthritis: 2-Year Clinical Outcome
Authors: IGN Reis , GMA Silva , TVO Campos , MAP Andrade
Published: November 2024

Objectives

Evaluate patients submitted to unicompartimental knee arthroplasty (UKA) by two surgeons with partial knee replacement expertise and, analyze the outcomes comparing a group of patients with preoperative isolated medial compartment arthritis to another group of patients with associated patellofemoral arthritis.

Methods

We conducted a retrospective cohort study to compare the clinical results of all patients submitted to UKA by two senior surgeons, between 2009 and 2020. All patients were submitted to partial knee arthroplasty using fixed-bearing Zimmer Unicondylar Knee System (ZUK). During analysis, they were divided into two groups, without patellofemoral arthritis (Group 1) and with patellofemoral arthritis (Group 2). Data collected from patient’s records included demographic information, range of motion (ROM), patient-reported outcome measures (PROMs) and preoperative radiographs. Only patients with minimum 2-year follow-up were included.

Results

Preoperative ROM was 122.6º (±6.2º) and 122.2º (±9.2º), in Group 1 and in Group 2, respectively (p-value = 0.9). While postoperative ROM was 114.5º (±2.9º) in Group 1 and 112.5º (±3.6) in Group 2 and, there was no statistical significance (p-value = 0.4). There was also no statistical significance regarding PROMs (Table 3). In Group 1, Oxford Knee Score was 17.1 (±1.8) and 40.2 (±2.1), before and after surgery, respectively. In Group 2, Oxford Knee Score changed from 18.8 (±1.9) to 40.5 (±2.5). The KOOS went from 129.3 (±15.2) preoperatively to 61.4 (±18.3) after surgery, in Group 1, while Group 2 evolved from 137.2 (±14.8) to 57.3 (±11.9). No complications were identified during the period studied.

Conclusion

UKA is an acceptable treatment option for unicompartimental tibiofemoral arthritis of the knee in patients with associated PFOA. There was an improvement in ROM of the knee, Oxford Knee Score and KOOS, with no differences between patients with or without PFOA.
Calculation of the Minimal Important Clinical Difference of the Lysholm and IKDC Scores After Anterior Cruciate Ligament Reconstruction
Authors: BF Nascimento , Mendes AF , Dias JM , J Antunes Filho
Published: November 2024

Objectives

To calculate the minimal important clinical difference (MICD) value for the Lysholm and International Knee Documentation Committee (IKDC) scores in a sample of patients submitted to anterior cruciate ligament reconstruction.To calculate the minimal important clinical difference (MICD) value for the Lysholm and International Knee Documentation Committee (IKDC) scores in a sample of patients submitted to anterior cruciate ligament reconstruction.

Methods

Primary, observational, retrospective, analytical study of participants submitted to anterior cruciate ligament reconstruction from March 2019 to December 2020 by the same surgeon, with a minimum follow-up of 6 months, analysis of knee function in the pre- and postoperative period by the Lysholm and IKDC scores, and answer to an anchor question at 6 months postoperatively for the calculation of the MICD of each score.

Results

A total of 59 patients participated in the study, with a mean age of 27.1 +- 5.7 years old. In the comparison between pre- and postoperative scores of all groups, there was an increase in values with statistical significance after intervention. The MICD was 5.5 for the Lysholm score, and the MICD value for the IKDC score could not be determined.

Conclusion

For the Lysholm score, the calculation of the MICD value by the anchor question method in the sample evaluated was 5.5. It was not possible to determine the value of the MICD for the IKDC score.
Challenges of Implementing a Human Multi-Tissue Bank in a Public Hospital: From the Perspective of the Quality Management System
Authors: GC Campos , LH Freitas Filho , CCS Neves , SR Piedade , JB Miranda , AR Zorzi
Published: November 2024

Objectives:

Various techniques have been developed to manage bone defects in revision knee arthroplasties, including bone grafts, which can be sourced from living or deceased donors as fresh-frozen or freeze-dried bone allografts, typically from bone banks. Human Multi-tissue Banks (HMTB) are crucial health institutions specializing in the procurement, processing, and distribution of human tissues for transplantation and research. They aim to ensure safety and quality in providing tissues for reconstructive surgeries and injury repair, while also advancing research in regenerative medicine. This study reports on the experience of implementing an HMTB and developing its own Quality Management System.

Methods:

This descriptive, experience report study identifies the historical actions of the HMTB over five years of implementing and operating the bone bank service.

Results:

The establishment of an HMTB with modern infrastructure and technological advancements, alongside the development and implementation of a quality management system, enabled excellent organization of work processes and the acquisition of the necessary health license to initiate activities.

Conclusion:

This report serves as a valuable source of information and provides recommendations applicable to the implementation of other human HMTBs.
Combined Anterior Cruciate Ligament and Anterior Oblique Ligament Reconstruction Using the Rectus Femoris Tendon: Surgical Technique Description
Authors: MCF Rego , BG Barroso , CP Helito , MCF Rego , SMG Canuto , PB Jorge
Published: November 2024

Objectives:

Present a combined anterior cruciate ligament (ACL) and anterior oblique ligament (AOL) reconstruction technique using a rectus femoris tendon graft harvested in a minimally invasive approach.

Methods:

Examination under anesthesia should confirm ACL insufficiency and associated anteromedial rotational instability. The graft is harvested from the lateral portion of the rectus femoris tendon using a closed tendon stripper with the knee at 20 degrees of flexion. The distal portion is folded to form a double graft for the ACL, while the proximal remainder is used for the AOL without folding. The femoral tunnel is made using an outside-in technique, and the tibial tunnel is created within the native ACL tibial footprint. ACL graft fixation is performed with an interference screw in both the femur and tibia, with the knee at 20° of flexion. The medial epicondyle is identified by palpation (or fluoroscopy) for AOL graft fixation. The remaining graft is tunneled subcutaneously and fixed with an interference screw at the femoral tunnel in neutral rotation and full extension.

Results:

The technique improved knee stability and controlled anteromedial rotational instability. It is reproducible and presents few complications.

Conclusion:

The described technique using the rectus femoris graft harvested via a minimally invasive approach is a viable alternative for combined ACL reconstruction and anteromedial reinforcement in both primary and revision surgeries.
Transtibial Femoral Tunnel Technique in ACL Reconstruction and Osteoarthritis Incidence
Authors: DANIELI MARCUS VINICIUS , MOLINARI ALLAN VIKTOR PIRES , SUZZE JOÃO VITOR GUEDES , DE ABREU VICTORIA , GUERREIRO JOÃO PAULO FERNANDES
Published: November 2024

Objectives

Evaluate osteoarthritis incidence in patients that undergone ACL reconstruction using the transtibial technique, with a minimum of 5 years of follow up, with isolated ACL injury.

Methods

Patients from a private clinic who underwent to ACL reconstruction by transtibial technique, with hamstrings graft, and with at least 5 years of follow-up, without any associated injury to the operated knee at the day of the surgery, were selected. All patients were operated on by the same surgeon. The patients were invited to perform X-Ray images of the operated knee to assess the presence of osteoarthritis. The Kellgren & Lawrence radiographic osteoarthritis classification was used. The grade I classification was already considered as the presence of osteoarthritis. The obtained results were analyzed by simple descriptive statistics, ie, obtaining the percentage of patients with osteoarthritis among those analyzed. Patients were also divided into 2 groups: between 5 and 10 of surgery, and with more than 10 years. The obtained data were evaluated by descriptive statistics.

Results

Forty-two patients (44 knees) were evaluated, with a mean age of 31 years old (SD: 8), being 23 right knees and 28 male patients. Mean time from surgery to imaging evaluation was 94.1 months (ranging from 60 to 154 months; SD: 28). Of the evaluated knees, 37 did not have osteoarthritis (83.3%) and 7 had (16.7%).

Conclusion

The ACL reconstruction performing the femoral tunnel through the transtibial technique in patients without another associated injuries to the operated knee, using quadruple hamstring graft, with a minimum of 5 years of follow up, showed an osteoarthritis incidence of 16.7% with a mean follow-up of 94.1 months.
Complete medial meniscal root injury and medial collateral ligament injury are risk factors for increased medial meniscal extrusion
Authors: Astur DC , Cohen M
Published: November 2024

Objectives

To evaluate the association between medial meniscus posterior root tear (MMRT) with anthropometric characteristics of the patient (age, weight, and height) and associated injuries identified on MRI (meniscal extrusion, medial collateral ligament [MCL] injury, bone edema, and subchondral fracture of the tibia).

Methods

The characteristics and associated injuries of 55 patients diagnosed with an injury (either partial or complete) of the root of the posterior horn of the medial meniscus, diagnosed on MRI and confirmed arthroscopically, were compared. Specifically, age, sex, anthropometric data, meniscal extrusion, associated MCL injury, and presence of associated bone edema were evaluated.

Results

There was a moderate positive correlation between the age of the patients and the degree of extrusion (r = 0.565; p < 0.0001). Greater meniscal extrusion was observed in patients who had complete medial meniscus root tear (C-MMRT) (p = 0.008). Patients with MCL injury presented with significantly greater meniscal extrusion when compared to individuals without MCL injury (p = 0.042). Similarly, the incidence of bone bruising was higher in patients with a MMRT with an associated MCL injury, when compared to patients without concomitant MCL injury (p=0.012).

Conclusion

Patients with a C-MMRT had greater meniscal extrusion than patients with a partial medial meniscus root tear (P-MMRT). The presence of a concomitant MCL injury was significantly associated with the meniscal extrusion in patients with concomitant meniscal root injury. The presence of associated bony edema was not associated with meniscal extrusion, but was significantly more common in patients with C-MMRT when there was an associated MCL injury compared to those without an associated MCL injury.
Defining Risk Factors for Medial Meniscus Posterior Root Repair Surgical Failure
Authors: Helito CP , Sobrado MF , Guimaraes TM , Silva da AGM , Pecora JR , Gobbi RG
Published: November 2024

Objectives

To evaluate the risk factors for failure of a repair of the posterior root of the medial meniscus, including the patient's preoperative factors, factors related to surgery and rehabilitation, already excluding factors such as uncorrected varus axis deviation and changes advanced degenerative diseases in the medial compartment.

Methods

Patients who underwent repair of the posterior root of the medial meniscus were evaluated retrospectively, although with prospective data collection. Repair of the meniscal root was performed using an arthroscopic method, using stitches tying the meniscus using high-resistance suture threads or tapes and fixation through one or two transtibial tunnels in the anterior cortex of the tibia with a button or anchor.

Results

Among the 125 patients evaluated, considering the adopted failure criteria, 28 (22.4%) were considered repair failure and 97 (77.6%) were considered successful. Comparing the groups, patients who were considered to have repair failure presented as pre- and intra-operative factors a greater proportion of female patients (p=0.0004), higher BMI (p=0.0009), greater number of associated procedures at the time of root repair (0.02) and greater number of chondral injuries in the femur (0.0005). Patients who failed the repair underwent surgery with a greater number of stitches (p=0.02), although only repairs with 2 or 3 stitches were included, and had worse compliance with rehabilitation (p=0.0001).

Conclusion

Repairs of injuries to the posterior root of the medial meniscus with transtibial tunnel have 77.6% good results with an average follow-up of around 4 years. Female gender, high BMI, surgery to correct the axis or treatment of cartilage injury concomitant with root repair, more pronounced chondral injury in the femoral cartilage, repair with 3 stitches instead of 2, and poor patient compliance with rehabilitation were related factors of repair failure.
Caregiver's Knowledge of Childhood Diarrhea Disease Prevention Strategies and Their Associated Factors in Dodoma, Tanzania. A Cross-Sectional Study
Authors: Saguda Nonhy , Msisiri Laidi S. , Masika Golden M. , Masanja Pendo P.
Published: November 2024

Introduction

Childhood diarrhea remains a leading cause of death in children under 5 years of age worldwide, although the disease is both preventable and treatable. Effective caregiver involvement, rotavirus vaccinations, and parallel diarrhea prevention are critical.

Objectives

This study aimed to assess caregiver's knowledge of childhood diarrheal disease prevention, rotavirus vaccination knowledge, and associated factors in Dodoma, Tanzania.

Methods

A hospital-based analytical cross-sectional study was conducted at Makole Health Center, Dodoma. Data were collected from 274 caregivers of children under 5 years of age who attended a routine immunization clinic. Respondents were interviewed using a semi-structured, pretested questionnaire. Data were analyzed for frequency, percentages, and mean, followed by multivariable linear logistic regression to examine the association between sociodemographic factors and caregiver's knowledge.

Results

A total of 274 subjects were involved in the study. The majority (93.8%) were women, all had formal education, (62.8%) knew that diarrhea in children can be prevented by proper handwashing, and only (9.9%) knew about the rotavirus vaccine. Educational level (β = 0.565 CI; 0.490, 0.873) p-value < .001, age of parents (β = 0.738 CI; 0.427, 1.050) p-value .022 and age of child (β = −0.306 CI; − 0.490, −0.122), p-value <.001 and the fact that the child was male (β = 1.116, 95% CI = 0.712, 1.520) p-value < .001) were the factors associated with participants’ knowledge.

Conclusion

The results highlight the great need for public health programs to increase awareness of rotavirus vaccines and parallel diarrhea prevention interventions, which in turn will significantly improve caregivers’ knowledge and therefore the prevention of diarrhea in children
Socio-economic Condition and Rehabilitation of Joginis in Telangana State
Authors: Bhasker K.
Published: November 2024

This article is an attempt to study the factors contributing to the prevalence of Jogini system in Telangana and looks at its day today practice. In contrast to the Devadasi attached to the temple, Joginis from the lower caste especially from the downtrodden and marginalized communities who are more vulnerable neither have any rights in the temple nor they have any skills to make livelihood but are still involved in a begging profession. An attempt is made here to analyse the socio-economic conditions and distribution of government schemes, their implementation and utilization as a part of the rehabilitation programmes to Joginis at micro-level. It also explores the impact of the rehabilitation programmes on the victims of the Jogini system as such these programmes are really transforming their livelihood pattern into better form or maintaining the same vulnerability as before.
Guthlee Ladoo: A Testimony of Persistence of Caste and Epistemic Injustice: A Critical Film Review
Authors: Das Kiran , Das Saswat Samay
Published: November 2024

The Hindi film Guthlee Ladoo strives to address the lacuna in the constitutionally protected Right to Education Act (RTE) by depicting a Dalit boy’s arduous journey to educational rights in a caste-ridden rural setting. Exploring the film’s portrayal of the continuation of caste-based untouchability and the unequal power dynamics among different castes, this critical film review discusses the distinctiveness of the director’s art in attempting to formulate a Dalit cinematic lens with the movie. Additionally, the film demonstrates how the privatization of education becomes a weapon at the hand of the upper castes in debarring the Dalit students from school premises. Finally, it examines how the film’s picturization of manual scavenging instantiates an unprecedented sketch of the Dalit body’s proximity to waste and its concomitant epistemic injustice.
Identifying CFIR Inner Setting Factors in the Implementation of a Salon-Based Intervention to Reduce Barriers and Improve Pre-Exposure Prophylaxis (PrEP) Uptake Among Black Women in US South
Authors: Jeter Elizabeth , Bacon Cynthia , Johnson Ragan , Lane Hannah , Randolph Schenita D.
Published: November 2024

US Black women are disproportionally represented in new HIV diagnoses. PrEP is effective in HIV prevention, but Black women’s uptake is low. The UPDOs salon-based intervention is effective in overcoming barriers to care but scaling implementation is needed. This mixed-method pilot study sought to understand how salon organizational factors may have influenced UPDOs implementation with a focus on organizational culture, team culture, relational connection, and communication within a Consolidated Framework for Implementation Research (CFIR) inner setting lens. Organizational culture and team culture were measured using the Organizational Culture Survey (OCS) and Team Psychological Safety Scale (TPS). Relational connection and communication were explored qualitatively using participant observations and semi-structured interviews. Findings were positive towards teamwork, morale, information flow, involvement, and supervision as well as reflected positive organizational environment that were supportive of developing knowledge and skills. Relational connection and communication created a trusting environment that facilitated implementation. Future research can benefit from examining organizational environment when scaling interventions to overcome HIV and PrEP inequities.
Is allogeneic transplantation for sickle cell disease still relevant in the era of gene therapy?
Authors: Jones Richard J. , Kassim Adetola A. , Brodsky Robert A. , DeBaun Michael R.
Published: November 2024

Sickle cell disease (SCD) is the most common inherited blood disease. Disease-modifying therapy and supportive care have improved the survival of children with SCD in the United States and Europe. Yet, adults with SCD continue to have high risks of morbidity and early death. Recently, 2 US Food and Drug Administration–approved genetic therapies offer the potential for a short-term decrease in acute vaso-occlusive pain events if not cure. Allogeneic hematopoietic cell transplantation (allo-HCT) is also curative but, until recently, was constrained by limited donor availability and the risks of graft-versus-host disease, graft rejection, and death. Importantly, recent advances have attenuated these barriers. Here, we discuss the current state of therapies with curative intent for SCD. Both genetic therapy and allo-HCT offer the potential for cure for most with SCD. However, the cost (∼5 times higher), the current need for myeloablation, and associated late-health effects may make genetic therapies less favorable choices than allo-HCT.
Integrating asthma care guidelines into primary care electronic medical records: a review focused on Canadian knowledge translation tools
Authors: McFarlane Matheson , Morra Alison , Lougheed M. Diane
Published: November 2024

Introduction

Asthma is one of the most common chronic respiratory diseases globally. Despite national and international asthma care guidelines, gaps persist in primary care. Knowledge translation (KT) electronic tools (eTools) exist aiming to address these gaps, but their impact on practice patterns and patient outcomes is variable. We aimed to conduct a nonsystematic review of the literature for key asthma care gaps and identify limitations and future directions of KT eTools optimised for use in electronic medical records (EMRs).

Methods

The database OVID Medline was searched (1999–2024) using keywords such as asthma, KT, primary healthcare and EMRs. Primary research articles, systematic reviews and published international/national guidelines were included. Findings were interpreted within the knowledge-to-action framework.

Results

Key asthma care gaps in primary care include under-recognition of suboptimal control, underutilisation of pulmonary function tests, barriers to care delivery, provider attitudes/beliefs, limited access to asthma education and referral to asthma specialists. Various KT eTools have been validated, many with optimisation for use in EMRs. KT eTools within EMRs have been a recent focus, including asthma management systems, decision support algorithms, data standards initiatives and asthma case definition validation for EMRs.

Conclusions

The knowledge-to-action cycle is a valuable framework for developing and implementing novel KT tools. Future research should integrate end-users into the process of KT tool development to improve the perceived utility of these tools. Additionally, the priorities of primary care physicians should be considered in future KT tool research to improve end-user uptake and overall asthma management practices.
TikTok and frozen shoulder: a cross-sectional study of social media content quality
Authors: D’Ambrosi Riccardo , Bellato Enrico , Bullitta Gianluca , Cecere Antonio Benedetto , Corona Katia , De Crescenzo Angelo , Fogliata Valentina , Micheloni Gian Mario , Saccomanno Maristella Francesca , Vitullo Fabrizio , Celli Andrea ,   SICSeG (Italian Society of Shoulder, Elbow Surgery) Research Committee
Published: November 2024

Purpose

This study aimed to assess the validity and informational value of the material provided on TikTok regarding frozen shoulders. The hypothesis was that the video content on this platform would not provide adequate and valid information.

Methods

The current study focused on frozen shoulder videos on the TikTok social media platform. The terms “frozen shoulder” and/or “adhesive capsulitis” were used as keywords for an extensive online search of video content on TikTok, and the first 100 videos were included. Out-of-topic, non-English, and duplicated videos were excluded from the analysis. The duration and numbers of likes, shares, and views were recorded for each video. Further, videos were categorized based on the source (physiotherapist/osteopath, medical doctor, or private user), type of information (physical therapy, etiopathogenesis, anatomy, clinical examination, patient experience, or symptoms), video content (rehabilitation, education, or patient experience/testimony), and the presence of music or a voice. The assessment of the video content’s quality and reliability was performed by two experienced shoulder surgeons using the DISCERN instrument, the Journal of the American Medical Association (JAMA) benchmark criteria, and the Global Quality Score (GQS).

Results

A total of 100 videos were included in the analysis, of which 86 (86.0%) were published by physiotherapists/osteopaths. Most of the information and video content focused on physical therapy and rehabilitation (83.0% and 84.0%, respectively). Eighty-four (84.0%) videos included voice comments, while the remaining featured music. The mean number of views was 2,142,215.32 ± 6,148,794.63, while the mean numbers of likes, comments, and shares were 58,438.67 ± 201,863.54, 550.81 ± 1712.22, and 3327.43 ± 7320.81, respectively. The mean video duration was 110.20 ± 116.43 s. The mean DISCERN score, JAMA score, and GQS were 16.17 ± 2.36, 0.61 ± 0.51, and 1.18 ± 0.41, respectively. Videos posted by medical doctors or private users received higher scores than those posted by physiotherapists/osteopaths (p < 0.05).

Conclusions

The educational value of videos published on TikTok was poor; videos posted by medical doctors exhibited better quality and educational value than those of physiotherapists or osteopaths. It is the responsibility of orthopedic surgeons to investigate the potential benefits, consequences, and implications of TikTok video content for the health of frozen shoulder patients and to propose necessary adjustments. Given the rapid growth of TikTok, further research is needed.

Level of evidence

Level IV—cross-sectional study.
Association of serum uromodulin with diabetic kidney disease: a systematic review and meta-analysis
Authors: Barr Shaimaa I. , Abd El-Azeem Eman M. , Bessa Sahar S. , Mohamed Tarek M.
Published: November 2024

Background

Several studies have investigated the association between the changes of serum uromodulin and diabetic kidney disease (DKD). However, the results are still controversial. Therefore, this meta-analysis was conducted to provide a comprehensive evaluation of the association between serum uromodulin levels and DKD.

Methods

PubMed, Cochrane library, Web of Science, and Scopus were systemically searched following the PRISMA protocol to identify the studies that reported the relationship between serum uromodulin level and DKD. To investigate the association between uromodulin and DKD, a standardized mean difference (SMD) with a 95% confidence interval (CI) was used. When significant heterogeneity was detected (I2 > 50%), sensitivity and subgroup analyses were performed to determine the source of heterogeneity. The quality assessment was determined using the Newcastle-Ottawa scale (NOS), and the publications bias were determined by the funnel plot and Egger’s test.

Results

In total, 6 studies with 1774 patients were included in the final analysis. The random effect model was used. The pooled results showed that the serum uromodulin levels were significantly decreased in patients with DKD (SMD: -0.31; 95% CI: -0.48 to -0.13) (I2 = 45%). Upon applying the sensitivity analysis, it showed (SMD: -0.38; 95% CI: -0.49 to -0.27) (I2 = 3%). Subgroup analysis showed that uromodulin level was significantly decreased in DKD regardless of the region of study, in America (SMD: -0.34; 95% CI: -0.51 to -0.17; p < 0.0001), Europe (SMD: -0.54; 95% CI: -1.06 to -0.02; p = 0.04), and Asia (SMD: -0.63; 95% CI: -1.15 to -0.11; p = 0.02), with stronger predictive value in America and Asia than in Europe. Additionally, uromodulin levels were significantly decreased in both type 1 (SMD: -0.34; 95% CI: -0.51 to -0.17; p < 0.0001) and type 2 diabetes (SMD: -0.58; 95% CI: -0.95 to -0.22; p = 0.002).

Conclusion

This meta-analysis showed a significant association between low levels of serum uromodulin and DKD. So, it could have a predictive role for DKD. However, its performance varied across subgroup analyses restricted by race and clinical settings. Moreover, further studies are required with a focus on the cut-off value for predicting diagnostic accuracy.
Detection of human enteric viral genes in a non-native winter crane fly, Trichocera maculipennis (Diptera) in the sewage treatment facilities at Antarctic stations
Authors: Lee Sook-Young , Kim Ji Hee , Kang Seunghyun , Park Kye Chung , Cho Sung Mi , Salinas Carla Ximena , Rebolledo Lorena , Benítez Hugo A. , Mejías Tamara Contador , Soutullo Alvaro , Juri Eduardo , Kim Sanghee
Published: November 2024

Background

The Antarctic environment is susceptible to the introduction of non-native species due to its unique ecosystem, which has evolved under geographical isolation and extreme climatic conditions over an extended period. The recent introduction of the non-native winter crane fly, Trichocera maculipennis, to maritime Antarctica may pose a potential threat to the Antarctic ecosystem. In this study, we evaluated the possibility of the mechanical transmission of viruses by T. maculipennis.

Methods

We assessed the potential for the mechanical transmission of viruses using next-generation sequencing (NGS), quantitative PCR (qPCR), and virus isolation methods from T. maculipennis (Tm)-related samples (Tm body-wash fluid and Tm body-ground samples) collected from habitats and sewage treatment facilities located at three research stations in Antarctica.

Results

Virome analysis detected the genomic fragments of human adenovirus (AdV) and human endogenous retrovirus (HERV) in Tm-related samples. These viruses are commonly found in human feces. In addition, plant viruses, such as pepper mild mottle virus (PMMoV) and cucumber green mottle mosaic virus (CGMMV), both known indicators of enteric viruses, were identified in all Tm-related samples, likely originating from wastewater. However, the low quantities of AdV and HERV genomes detected in Tm-related samples through qPCR, coupled with the non-viability of AdV in virus isolation tests, indicate that T. maculipennis has limited potential for mechanical transmission under the conditions in the studies.

Conclusions

Our study represents the first evaluation of the potential risk of non-native species serving as vectors for viral pathogens in Antarctica. Although the viruses detected were in relatively low quantities and non-viable, this study highlights the importance of further evaluating the risks associated with non-native species, particularly as the likelihood of their introduction increases to Antarctica due to climate change and increased human activity.

Graphical abstract