bluuebunny/crossref_metadata_2025 huggingface dataset:
Asas legalitas Hubungannya dengan Pasal 10 UU No 48 Tahun 2009 Tentang Kekuasaan Kehakiman Perspektif Konsep Ijtihad dalam Hukum Islam
Authors: Wandi Deden
Published: December 2020

Asas legalitas menimbulkan pro dan kontra, tidak bisa menjawab sepenuhnya permasalahan hukumyang terus berkembang dan berbenturan dengan ketentuan Pasal 10 Ayat 1 UU No. 48 Tahun 2009 tentang Kekuasaan Kehakiman yang menyatakan hakim tidak boleh menolak  untuk memeriksa, mengadili, dan memutus suatu perkara yang diajukan dengan dalih bahwa hukum tidak ada atau kurang jelas, melainkan wajib untuk memeriksa dan mengadilinya.  Sehingga Hakim dituntut untuk menemukan hukum sebagaimana yang ditegaskankan  dalam Pasal 5 Ayat 1 UU No. 48 Tahun 2009 tentang Kekuasaan Kehakiman yang berbunyi “hakim dan hakim konstitusi wajib menggali, mengikuti, dan memahami nilai-nilai hukum dan rasa keadilan yang hidup dalam masyarakat.”. Proses menggali dan memahami nilai hukum ini dalam konsep hukum islam disebut ijtihad.
PERAN MAJELIS PENGAWAS TERHADAP KETAATAN NOTARIS DALAM UPAYA PENEGAKKAN KODE ETIK DAN UNDANG-UNDANG NOMOR 2 TAHUN 2014 TENTANG PEMBAHARUAN ATAS UNDANG-UNDANG NOMOR 30 TAHUN 2004 TENTANG JABATAN NOTARIS
Authors: Santiaji Dera Reswara
Published: December 2020

Majelis Pengawas Notaris merupakan suatu badan yang mempunyai kewenangan dan kewajiban untuk melaksanakan pengawasan dan pembinaan terhadap Notaris sehingga tetap patuh terhadap Kode Etik dan Undang-Undang Nomor 2 Tahun 2014 tentang Pembaharuan atas Undang-Undang Nomor 30 Tahun 2004 tentang Jabatan Notaris (UUJN). Dalam menjalankan tugas jabatannya, tidak jarang ditemukan sebagian Notaris melakukan segala cara untuk mendapatkan klien bahkan tidak patuh terhadap Kode Etik dan UUJN, sebagaimana salah satu contoh kasus pelanggaran Notaris berdasarkan Putusan Majelis Pengawas Wilayah Provinsi Jawa Barat Nomor: 131/MPW-JABAR/2008. Oleh karena itu, penelitian ini bertujuan mengetahui peran Majelis Pengawas terhadap pengawasan ketaatan Notaris sebagai upaya penegakkan Kode Etik dan UUJN serta mengetahui peran Majelis Pengawas Daerah (MPD) dalam menindaklanjuti laporan pelanggaran Kode Etik dan UUJN. Penelitian ini menggunakan pendekatan yuridis normatif meliputi pendekatan perundang-undangan, pendekatan konsep, pendekatan kasus. Analisis data dilakukan dengan metode berpikir deduktif dengan menarik kesimpulan berdasarkan hal yang khusus dalam penelitian ini. Hasil penelitian bahwa peran Majelis Pengawas dalam upaya penegakkan Kode Etik dan UUJN terhadap ketaatan Notaris sangat dibutuhkan khususnya peran MPD yang berada pada tingkat Kabupaten/Kota dalam pengawasan secara langsung terhadap ketaatan Notaris. Dalam tindaklanjut laporan masyarakat, MPD menyikapi laporan tersebut berdasarkan UUJN dan Permenkumham No. M.02.PR.08.10 Tahun 2004, dengan tiga tahap yaitu menindaklanjuti dugaan pelanggaran, memanggil Notaris yang bersangkutan, dan memeriksa Notaris. MPD harus objektif dalam melakukan pemeriksaan salah satunya dengan menempatkan akta sebagai objek pemeriksaan yang dapat dibuktikan secara pembuktian lahiriah, pembuktian formal, dan pembuktian materiil. Dengan demikian, peran MPD sebagai lembaga yang mengawasi Notaris secara langsung mampu menegakkan Kode etik dan UUJN dengan cara dan metode yang terencana dengan baik.
PENERAPAN UNDANG-UNDANG TINDAK PIDANA KORUPSI DALAM MENANGANI KEJAHATAN PERBANKAN
Authors: Hindriana Linda
Published: December 2020

Perkembangan zaman, perkembangan ilmu pengetahuan, perkembangan ekonomi dan perdagangan memacu perkembangan tindak pidana korupsi. Korupsi merupakan suatu kejahatan yang sangat kompleks. Korupsi tidak saja terjadi pada sektor publik tapi merambah pada sektor swasta manakala aktifitas bisnisnya berhubungan atau terkait dengan sektor publik seperti sektor perbankan dan pelayanan publik. Perkembangan tindak pidana korupsi di bidang perbankan berkembang seiring meningkatnya industri perbankan sebagai lokomotif pembangunan nasional. Tujuan penelitian ini adalah untuk menganalisis faktor-faktor yang terjadi tindak pidana korupsi di bidang perbankan dan untuk menganalisis peran Bank Indonesia dalam upaya penanggulangan tindak pidana. Metode penelitian ini menggunakan metode yuridis normatif. Data yang digunakan data sekunder. Teknik Pengambilan data melalui studi kepustakaan. Hasil penelitian diperoleh bahwa terjadinya tindak pidana korupsi dibidang perbankan disebabkan beberapa aspek yaitu aspek individu pelaku yang berasal dari diri pelaku itu sendiri, aspek organisasi, aspek masyarakat dan aspek peraturan perundang-undangan, serta penegakan hukum dalam pencegahan dan pemberantasan korupsi di perbankan dapat dilakukan melalui sarana penal (penggunaan hukum pidana dan hukum administrasi pidana) dan non penal (peningkatan sistem pengawasan, penerapan prinsip kehati-hatian, financial safety net, dan penetapan sistem perbankan yang mengarah kepada praktik good corporate goverance.
Jangka Waktu Perlindungan Hukum Atas Hak Merek Dalam Tinjauan Maslahah Mursalah
Authors: Susanto Yoghi Arief
Published: December 2020

AbstrakPenelitian ini bertujuan untuk mengkaji kesesuaian terhadap jangka waktu perlindungan hukum atas hak merek dalam UU No. 20 tahun 2016 tentang Hak Merek dan Indikasi Geografis dengan Konsep Maslahah Mursalah dalam Hukum Islam. Penelitian ini menggunakan  pendekatan yuridis normatif, dengan metode deskriptif analitis, dengan analisis menggunakan library research.   Hasil penelitian ini menjelaskan bahwa jangka waktu dalam UU merek  tidak bersifat mutlak karena bisa diperpanjang , dengan tujuan kemaslahatan agar barang/jasa dari merek tersebut bisa dirasakan manfaatnya bagi masyarakat, tidak dibiarkan setelah di daftarkan, hal ini berkaitan dengan perpanjangan merek di pasal 36 UU Merek. Kedudukan merek yang tidak terdaftar tidak memiliki kekuatan hukum dan perlindungan hukum, sehingga berpotensi menimbulkan mafsadat padahal hal tersebut harus di hindari karena tidak memberikan kepastian hukum.Kata Kunci : Hak Merek, Perlindungan, Maslahah Mursalah.
ANALISIS YURIDIS PENERAPAN DIVERSI TERHADAP ANAK YANG BERHADAPAN DENGAN HUKUM DIHUBUNGKAN DENGAN PERATURAN MAHKAMAH AGUNG NOMOR 4 TAHUN 2014 TENTANG PEDOMAN PELAKSANAAN DIVERSI DALAM SISTEM PERADILAN PIDANA ANAK
Authors: Danawiharja Yusuf Luqita
Published: December 2020

Penanganan anak yang berkonflik dengan hukum seringkali disamakan dengan penanganan orang dewasa yang melakukan tindak pidana. secara yuridis di Indonesia, perlindungan hukum terhadap anak dapat dijumpai di berbagai peraturan perundang-undangan. Semua peraturan perundang-undangan bertujuan untuk menciptakan kesejahteraan, melindungi hak-hak anak untuk mewujudkan keadilan bagi anak. Dalam penelitian ini penulis menggunakan metode pendekatan yuridis normatif. Spesifikasi Penelitian, penelitian ini bersifat deksriptif analitis. Jenis data, yaitu data sekunder. Pengumpulan data dilakukan melalui studi kepustakaan (Library Research) terhadap data sekunder. Data yang diperoleh dalam penelitian ini dianalisis dengan menggunakan metode normatif kualitatif.  Hasil dari penelitian ini ialah. Pertama, Penerapan diversi terhadap anak baik pada tingkat Penyidikan, Penuntutan dan Peradilan dapat dilaksanakan selama memenuhi persyaratan, sebagaimana diatus dalam Pasal 7 angka 2 Undang-Undang Sistem Peradilan Pidana Anak dan sesuai dengan Perma Nomor 4 Tahun 2014 tentang Pedoman Pelaksanaan Diversi Dalam Sistem Peradilan Pidana Anak yang menyatakan bahwa diversi dapat dilaksanakan dalam hal tindak pidana yang dilakukan dengan diancam pidana penjara di bawah 7 (tujuh) tahun dan bukan merupakan pengulangan tindak pidana. Kedua, Kendala Implementasi Diversi dalam penanganan tindak pidana yang dilakukan oleh anak, dimana korban merasa haknya tidak dilindungi karena tersangka diberikan keistimewaan dalam proses hukum. Adapun pihak korban dan keluarganya dalam hal ini beranggapan bahwa pelaksanaan hukum cenderung berat sebelah dan memihak kepada tersangka.
STRATEGI KEBIJAKAN MENGURANGI FRAUD DALAM KLAIM BPJS DITINJAU DARI PERMENKES NO.36 TAHUN 2015
Authors: Marriska Keika
Published: December 2020

Setiap individu berhak mendapatkan pelayanan kesehatan. Untuk itulah pemerintah membuat program BPJS Kesehatan.  Namun dalam pelaksanaanya, ditemukan kendala berupa fraud. Sebagai upaya pencegahan fraud, pemerintah menerbitkan Permenkes 36/2015. Metode penelitian: yuridis normatif. Kesimpulan: (1) Mekanisme fraud oleh peserta : pemalsuan status kepesertaan dan  kondisi kesehatan; oleh pemberi pelayanan: upcoding, fragmentation,readmisi, no medical value, type of room charge; oleh pembuat kebijakan: menahan pembayaran ke fasilitas kesehatan, membayarkan dana kapitasi tidak sesuai dengan ketentuan; (2) Implementasi Kebijakan: penyusunan kebijakan dan pedoman pencegahan fraud, pengembangan budaya pencegahan fraud, pembentukkan tim pencegahan fraud; (3) Strategi pencegahan fraud: kesadaran pihak terkait terhadap fraud, menentukan standar pelayanan kedokteran, meninjau ulang secara berkala paket INA-CBG’s/kapitasi; keseragaman penyediaan dan pemakaian obat/alkes sesuai fornas.; memperkuat pengawasan di Kemenkes dan BPJS Kesehatan.Kata Kunci :  Fraud, Klaim BPJS, Permenkes 36/2015.
PERLINDUNGAN HUKUM BAGI BIDAN YANG MENERIMA PELIMPAHAN KEWENANGAN TINDAKAN KEBIDANAN DIHUBUNGKAN DENGAN UNDANG-UNDANG NOMOR 4 TAHUN 2019 TENTANG KEBIDANAN DAN UNDANG-UNDANG NOMOR 44 TAHUN 2009 TENTANG RUMAH SAKIT
Authors: Mujiwati Mujiwati
Published: December 2020

Kesehatan merupakan bagian penting dari kesejahteraan masyarakat. Kesehatan juga merupakan salah satu kebutuhan dasar manusia. Sejalan dengan amanat Pasal 28 H Undang-Undang Dasar 1945 telah ditegaskan bahwa setiap orang berhak memperoleh pelayanan kesehatan Bidan dalam menjalankan praktiknya harus sesuai dengan standar, baik standar pelayanan, standar profesi, dan standar operasional prosedur. Akan tetapi dalam praktiknya terkadang bidan menerima pelimpahan tindakan dari dokter dalam menangani pasiennya, dalam hal terjadinya kerugian terhadap pasien maka diperlukan peraturan yang jelas dalam akibat hukumnya. Atas dasar latar belakang diatas maka yang menjadi persoalan yaitu bagaimana pelimpahan wewenang tindakan kebidanan dihubungkan dengan Undang-Undang Nomor 4 Tahun 2019 Tentang Kebidanan dan Undang-Undang Nomor 44 Tahun 2009 Tentang Rumah Sakit serta bagaimana perlindungan hukum bagi bidan yang menerima pelimpahan tindakan kebidanan dihubungkan dengan Undang-Undang Nomor 4 Tahun 2019 Tentang Kebidanan dan Undang-Undang Nomor 44 Tahun 2009 Tentang Rumah Sakit. Untuk maksud tersebut, dilakukan penelitian dengan menggunakan pendekatan yuridis normatif yaitu melihat hukum dari aspek norma, sehingga hanya melalui proses studi kepustakaan atau hanya pada hukum yang tertulis saja. Pendekatan masalah yang digunakan oleh peneliti adalah pendekatan perundang-undangan (statute approach). Berdasarkan hasil analisis bahwa Pelimpahan kewenangan tindakan kebidanan berdasarkan Undang-Undang No. 4 Tahun 2019 tentang Kebidanan belum diatur secara tegas terkait tindakan apa saja yang dapat dilimpahkan sehingga bidan belum memiliki perlindungan hukum secara jelas. Sejauh tindakan bidan tersebut tidak melebihi batas kewenangan serta sesuai dengan SOP dan pelimpahan wewenang maka bidan tidak dapat dimintakan pertanggungjawabannya kecuali terbukti bahwa bidan melakukan tindakan yang menyebabkan pasien cacat sampai meninggal dunia dapat dimintakan pertanggungjawaban baik melalui hukum administrasi, perdata maupun pidana.
Mental training and influence of temperamental dimensions in preparation of the Czech Republic weightlifting representative in junior category under 23 years: Case study
Authors:   Czech Weightlifting Association, Prague, Czech Republic, Krol Petr , Štěrbová Dana ,   Palacký University Olomouc, Czech Republic
Published: December 2020

Background. According to the coaches, the weightlifters of the national team show deficiencies in mental skills, which leads to unbalanced performance at top competitions. Based on the knowledge of the efficacy of mental training (MT) from other sports, it is possible to conclude the potential of the MT in top weightlifting. Objective. The main aim of the authors was to create and verify a program based on mental training techniques implemented in sports training of weightlifter of the junior category of the Czech Republic, and also to reflect the influence of the competitor's tem­peramental dimensions on the implementation of the MT program in her sports training. Methods. Semi-structured interviews with the athlete and the coach before and after the implementation of the mental training program were conducted. A psychodiagnostic tests – Test of attention d2 and TEZADO measuring attention resp. temperamental dimensions were used in addition to subjective statements. Self-assessing scales were also used to obtain more quantitative data. Results. Results showed that some of the mental training techniques had a positive effect on deficient mental skills. These mental skills are crucial in the preparation of the weightlifting representative and can have a significant influence on a sports athlete's per­formance. The most significant difference was achieved in the skill of refocusing and the smallest difference in imagination. According to the subject, the influence of the temperamental dimensions on the mental training program had a significant impact in connection with the refocusing and anger coping. Conclusion. Mental training techniques can help top weightlifters to overcome the mental skills deficiencies used in their sports training, which may have a positive influence on performance in both training and competitions. Self-knowledge of the temperamental dimensions is significant to the success of the program.
Vyjádření k rozhovoru Radima Uzla ze dne 8. 12. 2020
Authors:   Masaryk University Brno, Czech Republic, Bartošová Kateřina , Cíglerová Jana , Cígler Hynek
Published: December 2020

Dne 8. 12. 2020 byl na DVTV odvysílán rozhovor s Radimem Uzlem. Protože v rozhovoru zaznívají informace a názory, které jsou v rozporu nejen s aktuálními psychologickými poznatky, ale i s etickými normami a obyčejným slušným chováním, považujeme za nezbytné se k němu vyjádřit.
Pengembangan Model Pembelajaran Student Oriented dalam Meningkatkan Kemampuan Pemecahan Masalah Fisika Peserta Didik
Authors:   Program Studi Pendidikan Fisika, PMIPA, Universitas Mataram, A Syahrial , Afifah Gusti ,   SMA Negeri 2 Mataram, Dinas Pendidikan dan Kebudayaan Mataram, Gunada I Wayan ,   Program Studi Pendidikan Fisika, PMIPA, Universitas Mataram
Published: December 2020

In the development of student oriented learning models to improve students' physics problem solving ability aims to develop a student-oriented learning model consisting of a syllabus, lesson plans, student worksheet and problem solving ability evaluation tools (KPM). This study uses a research and development type with a 4D model research design, namely Define, Design, Develop, and Desseminate. At the Define stage, curriculum analysis, student ability analysis, task analysis, concept analysis and analysis of learning objectives are carried out. The design stage is carried out by designing the learning device. At the Develop stage, product manufacturing, product expert validation, product revisions, testing of problem-solving ability evaluation tools were carried out, while at the Desseminate stage there was no product distribution on the grounds that it was still in the COVID 19 pandemic. The try out was conducted on a research sample (30 students) class XI MIPA4 SMA Negeri 2 Mataram which was conducted online. The results of the expert validator analysis of the student oriented learning model obtained valid results. Reliability and validity tests of the problem solving ability evaluation (KPM) instrument obtained reliable and valid results. Based on these findings, it can be concluded that the learning tools and problem solving ability evaluation tools are feasible to be applied to classroom learning.
YI 1.1 Aortic Impedance and Total Arterial Compliance from Regional Pulse Wave Velocities
Authors: Bikia Vasiliki , Rovas Georgios , Pagoulatou Stamatia , Stergiopulos Nikolaos
Published: December 2020

Background

In-vivo assessment of aortic characteristic impedance (Zao) and total arterial compliance (CT) has been hampered by the need for invasive methods to access simultaneous recordings of aortic pressure and flow, wall thickness, and cross-sectional area. In contrast, regional pulse wave velocity (PWV) measurements are noninvasive and clinically available. Given that PWV is strongly related to aortic stiffness (1), we assume that carotid-to-femoral PWV (cfPWV) and carotid-to-radial PWV (crPWV) may contain sufficient information to evaluate the elasticity of the ascending aorta. Concretely, here, we present a noninvasive regression method for estimating Zao and CT using cuf pressure, cfPWV, and crPWV.

Methods

Gradient Boosting is employed for predicting Zao, and CT. The regressors are trained/tested using a pool of virtual subjects (n = 4833) generated from a previously validated in-silico model (2). The cross validation is performed using a 10-fold cross-validation (3).The population used has been previously generated (4) and reflects a wide range of hemodynamical properties and states.

Results

Predictions had a high accuracy (Figure) achieving a normalized-RMSE equal to 6.24 ± 1.19% (r = 0.85, p < 0.001) for Zao, and 4.38 ± 0.36% (r = 0.97, p < 0.001) for CT, respectively. High errors were reported for high values of Zao due to the limited amount of similar data.

Conclusion

The proposed approach constitutes a step forward to noninvasive screening of elastic vascular properties in human by exploiting easily obtained measurements. This study could introduce a valuable tool for assessing aortic stiffness reducing the cost and the complexity of the required measuring techniques. Clinical evaluation is required to validate the method in-vivo.
YI 2.2 Spontaneous Cardiovascular Ageing of C57BL6 Mice Results in the Development of Aortic Stiffness Prior to Periphral Blood Pressure Alterations
Authors: De Moudt Sofie , Hendrickx Jhana O. , De Munck Dorien G. , Leloup Arthur J. , Martinet Wim , De Meyer Guido R. Y. , Fransen Paul
Published: December 2020

Background

Although generally assumed to be an adaptive response to increased blood pressure (BP), arterial stiffness is now recognized as an independent predictor of cardiovascular (CV) events [1]. Moreover it precedes hypertension in at least two mouse models [2,3]. Therefore, the present study aims to investigate the temporal development of aortic stiffening and peripheral blood pressure (BP) alterations in spontaneously ageing mice.

Methods

A longitudinal cardiovascular characterization of spontaneously ageing C57Bl6 mice (2, 4, 6, 9, 12 and 24- month old) (male, n > 8) was performed. This includes in vivo analysis of peripheral BP (Coda) and aortic pulse wave velocity (aPWV, Vevo2100), combined with ex vivo aortic studies of isometric reactivity (organ baths) and aortic stiffness measurements (Peterson modulus, Ep) in the Rodent Oscillatory Tension set-up for Arterial Compliance (ROTSAC).

Results

In vivo and ex vivo characterisation confirms that aortic stiffness precedes peripheral BP alterations in spontaneously ageing C57Bl6 mice, with significantly increased aPWV from 6 month of age (Figure A), whereas peripheral BP measurement only shows elevated pulse pressure in 24 month old mice (30% increase vs. all other ages, Figure B). Ex vivo investigation of the thoracic aorta further reveals that the aortic stiffening is both contraction-independent (Figure C) and dependent (Figure D), since older mice display increased contractions to phenylephrine (PE) (Figure E and F).

Conclusion

Spontaneously ageing C57Bl6 mice present with significant aortic stiffness by 6-months of age, which is both contraction-dependent and independent in origin. Aortic stiffness thereby precedes the development of peripheral BP alterations by 18 months.
P.01 Where Does the Reflected Wave Observed in the Ascending Aorta Come from?
Authors: Abdullateef Shima , Khir Ashraf W.
Published: December 2020

Background

Wave reflections play a major role in changing the shape of the pressure waveform. Reflections measured at the aortic root (AR) are thought to be due to the tapering of the aorta [1] and multiple reflection sites, however, there is no consensus on the source of those reflected waves. This research aims to better understand the origin of the reflected waves observed in AR.

Methods

A 1D computational model of arterial wave propagation was used to study the reflections in an arterial network that consists of 37 segments of large arteries [2]. A pulse was inserted in 3 peripheral vessels (Figure 1) and followed as it travelled back towards AR. A pressure ratio (PR) was described as the ratio between the pressure at AR to the inlet pressure to allow for comparisons between the effect of various reflected sites.

Results

The pulse wave lost its magnitude travelling back towards the heart. The pulse inserted from the iliac artery could hardly be observed in AR (Figure 2), and only 1% of the waves’ magnitude could be detected. PR of the wave inserted at the carotid artery is approximately 18 times larger than those generated at the iliac artery; both measured in the ascending aorta.

Conclusion

Waves reflected from the carotid bifurcation and the cerebral circulation are more likely to be seen in AR in comparison to reflected sites such as renal and iliac arteries. Further work is warranted to establish the contribution of reflections generated from various sites along the arterial bed.
P.02 Differential ‘Mediators’ of Low-Flow ‘Mediated’ Constriction in Healthy vs Patients of Ischemic Heart Disease
Authors: Badhwar Smriti , Chandran Dinu , Jaryal Ashok , Narang Rajiv , Patel Chetan , Deepak Kishore Kumar
Published: December 2020

Background

Low-flow mediated constriction (LFMC) has emerged as a non-invasive tool for assessment of endothelial dysfunction [1]. There is insufficient data on association between change in artery diameter during occlusion with its possible stimulus; ‘low flow’ state. This study aims to evaluate the association between change in brachial-artery diameter during constriction with alterations in retrograde, anterograde and oscillatory flow profile in healthy subjects and patients with ischemic heart disease (IHD).

Methods

Brachial-artery responses to occlusion were assessed from artery diameter and blood flow using B-mode and pulsed-wave doppler ultrasound respectively in 89 patients with IHD and 29 healthy subjects. Change in anterograde, retrograde and net flow velocity, shear rate (AFV, RFV, NFV, ASR, RSR and NSR respectively) and oscillatory shear index (OSI) during forearm occlusion at 50 mmHg above systolic pressure, from baseline was calculated.

Result

Diameter deceased significantly in healthy subjects and patients during occlusion compared to baseline. Interestingly, in stepwise forward-selection analysis, change in maximum AFV, ASR, RSV and RSR emerged in best fit model, explaining 76.2% of total variability in delta LFMC in IHD patients, with maximum contribution by ASR (70.4%). On the other hand, in healthy, change in maximum RFV, RSR, NFV and NSR emerged in best-fit model explaining 89.9% of total variability, of which 47% was by NSR and 33% by RSR.

Conclusion

Brachial-artery constriction during occlusion is ‘mediated’ by decrease in ASR in patients of IHD and decrease in NSR and increase in RSR in healthy, highlighting the possibility of differential ‘mediators’ of constriction in healthy vs diseased.
P.05 Development and Validation of a Novel Centroid Method for Estimating Effective Reflection Time
Authors: Kondiboyina Avinash , Smolich Joseph J , Cheung Michael M H , Mynard Jonathan P
Published: December 2020

Background

The time at which reflected waves arrive at central arteries has an important influence on ventricular afterload. Current methods of estimating reflection time (RT), including zero-crossover [1], inflection-point [2], and foot methods [3], use only a single point on the pressure waveforms, and their accuracy is uncertain because no ground truth reflection time (GTRT) has been available. We here introduce a novel centroid method that accounts for the entire waveform and compare the accuracy of RT methods by comparison with a GTRT for the first time.

Methods

Using computational linear wave-tracking, we followed an impulse as it traversed through an anatomical model of the systemic arterial circulation; GTRT was calculated as the weighted mean arrival time of reflected waves at the inlet. Linear convolution of the resulting impulse response with a realistic input waveform (flow waveform multiplied by characteristic impedance) produced a pressure waveform that was separated into forward and backward components. The time difference between the centroids of the backward pressure and input waveforms was taken as RT in the centroid method. We also conducted a parameter sweep (n = 300) on the model to test the accuracy and robustness of the various methods.

Result

Compared to the zero-crossover, inflection-point, and foot methods, the centroid method estimated RT with the least mean difference to GTRT (104, 107, 171 vs. 8 ms; p < 0.001) and least standard deviation (34, 109, 97 vs. 28 ms).

Conclusion

The centroid method substantially improved accuracy and robustness for estimating RT compared with current methods.
P.09 Differential Low Flow Mediated Constriction (LFMC) Responses in Radial and Brachial Arteries of Healthy Humans are Attributed to Occlusion Induced Flow Changes
Authors: Sen Sakshi , Chandran Dinu , Jaryal Ashok , Deepak Kishore Kumar
Published: December 2020

Background

Literature describes differences in Low flow mediated constriction (LFMC) of radial versus brachial artery [1,2]. We investigated whether differences in occlusion induced changes in luminal flow and shear rates could explain the observed radial vs brachial differences in LFMC responses.

Methods

Twenty Healthy volunteers (Age 23.50 ± 2.06 years) underwent examination of Brachial and radial arteries of both the arms. Arteries were visualized in Pulsed wave doppler in duplex mode (Vivid-e; GE Healthcare) using a 12 MHz probe at baseline and during low flow state produced using an occluding cuff placed around the forearm (for brachial artery) and over the wrist joint (for radial artery) inflated to supra-systolic pressures.

Results

LFMC in Radial artery was significantly higher than that of Brachial artery [delta LFMC of –0.58 mm (–0.24––0.76) in radial artery vs 0.03 mm (0.21––0.13) in brachial artery; p < 0.0001). Occlusion induced reduction in anterograde shear rate was comparatively higher in radial artery than brachial artery [–67.9% (–43––77) in radial vs –56.7% (–40.9––65.4) in brachial; p = 0.0098] whereas, the rise in retrograde shear rate and changes in oscillatory shear index were comparable between both. Percentage changes in anterograde shear rate and anterograde flow velocities emerged as independent predictors in the regression model that explained 86% of the variance in LFMC responses of brachial artery.

Conclusion

Discrepancies in the LFMC responses of radial vs brachial artery could be attributed to the occlusion induced differences in the anterograde shear rate and anterograde flow velocities.
P.18 Carotid Stiffness Parameters and Cerebral Blood Flow Pulsatility in Young Healthy Individuals across Races
Authors: Liu Jie , Favre Michelle E. , Iring Stephanie G. , Knox Allan , Serrador Jorge M.
Published: December 2020

Background

Higher cerebral blood flow (CBF) pulsatility was found to be associated with severer brain white matter lesions in the elderly [1]. It was hypothesized that the central/elastic arterial stiffness/compliance may directly affect CBF pulsatility. However, it is still unclear which carotid stiffness parameters may better reflect this impact, and whether race and sex differences are present.

Methods

To study the correlations among those parameters with comparisons between different races and sexes, we enrolled 35 young healthy subjects (19 females), aged 29 ± 5 (18~40) years, with three races of comparable age and sex ratio, i.e. White (n = 16), Black (n = 7), and Asian (n = 12). All subjects were in resting seated position, with continuous transcranial Doppler recording of CBF velocity at middle cerebral artery (MCA), simultaneous 1-min ultrasound echo-tracking on bilateral common carotid arteries, and multiple measurements of brachial blood pressure (BP).

Results

All derived parameters [2], including MCA pulsatility index (PI), showed no significant racial differences but with significantly (p < 0.05) higher carotid stiffness index (β), Peterson’s pressure modulus (Ep), BP pulsatility index (mostly driven by higher systolic BP but similar diastolic BP), and lower arterial compliance (AC, p = 0.07) in males than in females. Only AC (but not β and Ep) showed a significant correlation with PI (r = 0.49, p = 0.004) even after controlling for BP pulsatility index, which negatively correlated with AC (β = −0.35, p = 0.038).

Conclusions

Higher carotid AC (i.e. decreased stiffness) seems to enhance CBF pulsatility in young healthy populations, which might differ from the elderly.
P.31 Von Willebrand Factor Induces Vascular Smooth Muscle Cell Proliferation and Migration Through Low Density Lipoprotein-Related Receptor Protein 4 and αvβ3 Integrin
Authors: Denis Cécile V. , Lacolley Patrick , Lagrange Jeremy , Lenting Peter J. , Michel Jean-Baptiste , Raoul Alexandre , Regnault Veronique
Published: December 2020

Background and Objectives

Von Willebrand factor (VWF) is a plasma glycoprotein involved in primary hemostasis but recent data suggest additional roles beyond hemostasis in angiogenesis and potentially in vascular smooth muscle cell (VSMC) proliferation. Our aim was to investigate how VWF can modulate VSMC proliferation and identified the underlying mechanisms and the in vivo pathophysiological relevance.

Methods and Results

Cultured aortic VSMCs proliferation and migration were increased in the presence of VWF. VSMCs treatment with a siRNA targeting αv integrin or the RGT-peptide blocking αvβ3 signaling completely inhibited proliferation. VWF did not bind directly to αvβ3 on VSMCs. We identified that VWF A2 domain was able to bind VSMCs. Since the lowdensity lipoprotein-related receptor protein (LRP) family are known to act as co-receptors we hypothesized the involvement of a member in the signaling pathway. Using the universal LRP-inhibitor (RAP), we confirmed LRP-mediated VSMC proliferation. siRNA experiments and proximity ligation assay staining identified LRP4 as the VWF-counterreceptor on VSMCs and showed co-localization between αvβ3 and LRP4. Carotid ligations were applied to VWF +/+ and −/− mice and intimal hyperplasia (IH) was measured. Less VWF−/− mice developed IH compared to VWF +/+ mice. Finally the proliferative effect of VWF was confirmed in human atherosclerotic lesions from different vessels (aortas, carotids) showing a proximity between VWF and a-SM actin positive cells.

Conclusions

VWF mediates VSMC proliferation through its A2 domain binding to the LRP4 receptor and integrin αvβ3signaling. The decreased IH following vascular injury suggests that targeting VWF-LRP4 interactions may contribute to limit remodeling.
P.66 Radial Artery Systolic-Diastolic Pulse Transit Time After Kidney Transplantation
Authors: Philibert Emy , Obeid Hasan , Paré Mathilde , Côté Nadège , Fortier Catherine , Goupil Rémi , Agharazii Mohsen
Published: December 2020

Purpose/Background/Objective

We have previously shown that restoration of kidney function through kidney transplantation (KTx) is associated with improved aortic stiffness. In this study, we aim to examine whether this change in aortic stiffness translates into improvement of radial artery systolic-diastolic pulse transit time.

Methods

Before and three months after KTx, we obtained radial pressure waveforms using applanation tonometry, in a group of 61 patients with restored renal function (eGFR > 45 ml/min/1,73 m2). Radial waveforms were recorded over a 10 seconds period and ensemble-averaged (using in house-MATLAB program) to obtain a single waveform and then modelled using two Gaussian functions, was then determined as the transit time between the first systolic peak T1 and the early diastolic peak T2.

Results

61 patients (66% male, mean age: 48 ± 14 years, mean eGFR 3 months after Ktx: 66.0 ± 17.1) were assessed. After KTx, there was a significant reduction in central systolic (125,266 ± 21,848 to 108,994 ± 14,407, p < 0.001) and diastolic BP (84,718 11,679 to 74,092 9,774, p < 0.001), carotid-femoral PWV (11,444 2,626 to 10,235 1,890, p < 0.001) and carotid-radial PWV (9,350 1,485 to 8,831 1,291, p = 0,003). While T1 declined (0.184 [0.173–0.198] to 0.180 [0.168–0.194], p = 0.018), there were no significant changes in T2 (0.322 [0.295–0.360] to 0.318 [0.283–0.355], p = 0.169) and in dT1-2 (0.135 [0.119–0.161] to 0.134 [0.117–0.167], p = 0.457).

Conclusions

Contrary to our expectation, three months after KTx, we did not observe a significant change in radial systolic-diastolic pulse transit time after kidney transplantation, despite an improvement of BP, aortic and brachial stiffness.
P.67 The Effects of Chemotherapy on Arterial Inflammation Assessed by 18FDG PET-CT in Patients with Lymphoma
Authors: Anagnostopoulos Constantinos , Giannouli Stavroula , Ioakimidis Nikolaos , Kafouris Paulos , Koutagiar Iosif , Sioni Anastasia , Solomou Eirini , Terentes-Printzios Dimitrios , Tousoulis Dimitrios , Vlachopoulos Charalampos
Published: December 2020

Introduction

Anti-cancer treatment can lead to increased cardiovascular morbidity among lymphoma survivors[1]. This may be the result of direct effect of treatment on heart function, or indirect acceleration of atherosclerosis. 18F-fluorodeoxyglucose (FDG) uptake is a sensitive and robust marker for assessment of atherosclerotic inflammation [2,3,4].

Purpose

To investigate the effects of chemotherapy on arterial inflammation using FDG-PET CT in patients with lymphoma.

Methods

Fifty nine (mean age 58 ± 17 years) patients with Hodgkin (n = 39) or non-Hodgkin lymphomas (n = 20) underwent 18FDG PET-CT imaging at baseline, interim and after completion of chemotherapy as part of their routine protocol. Arterial inflammation was assessed by arterial target to background ratio (TBR) of the aortic wall along the entire aorta. The index vessel TBR (the vessel with the higher value at baseline) was used for assessment of arterial inflammation. Patients with Hodgkin Lymphomas (HL) underwent therapy with Doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD). The interim of their treatment was set at 1 to 3 days prior to initiating the 3rd chemotherapy cycle. Patients with non Hodgkin Lymphomas (NHL) underwent therapy with cyclophosphamide, doxorubicin, vincristine, and prednisone + rituximab (R-CHOP). The interim of their treatment was set at 2 weeks post the 4th chemotherapy cycle. All patients we reassessed 6 weeks after chemotherapy completion.

Results

There were no differences in age and atherosclerotic risk factors (hypertension, diabetes, dyslipidemia and smoking), between the two groups (all p > 0.05). Similarly, there were no differences in mean (± SD) index vessel TBR between HL and NHL patients (2.4 ± 0.7 vs 2.7 ± 0.9, respectively, p = 0.65). In the whole study population the index vessel TBR progressively decreased after the end of therapy (by 0.53 ± 0.11, from baseline to 6 weeks following the end of therapies) (F = 10.94, p < 0.001, ANOVA). The index vessel TBR decreased in both HL and NHL patients at 6 weeks after therapy compared to baseline level (all p < 0.01, ANOVA, Figure). The decrease at the interim scan was more pronounced in NHL compared to HL patients, however at 6 weeks after chemotherapy completion the index vessel TBR decreased further in patients with HL, while it increased slightly compared to interim levels in NHL patients (Figure).

Conclusion

Arterial inflammation is reduced during and post-chemotherapy in patients with lymphoma. The index vessel TBR changes at the interim phase and 6 weeks after therapy completion indicate a different effect of specific treatment regimes in arterial inflammation between HL and NHL patients.
Hoaks, Politik dan Risiko Masyarakat Modern
Authors: Jehamat Lasarus , Jelahut Yosef Emanuel , Damanik Dasma A.
Published: December 2020

Indonesia’s social space in the past year has been filled with the phenomenon of hoax. The phenomenon of hoax develops alongwith the strengthening and thickening of the national political axis. Society is not treated by true news but it is filled withvarious emotional outbursts. The implication is that the community is divided into small groups based on interests. This causesthe social and cultural space to be rigid and inflexible. By Ulrich Beck, such phenomena are called risk society. Risks arise notonly because of technological developments in physical reason but also because of erroneous social and political practices. In itsdevelopment, Indonesian politics follows the trend of thickening into groups. A society divided into groups has the potential tostrengthen internal integration. As a result, the level of external adaptation is low. Politics is called the most vulnerable regionand is therefore responsible for social divisions. Because of politics, elements of society make social media not only a tool butalso their ultimate goal. There, the people practice various news provocation movements the truth of which cannot be verified.Such reality demands state responsibility in managing the media. Media management is not the same as controlling media.Managing the media is providing literacy education not only to the media and the political elite but also to the general public.Consequently, the logical reasoning for the existence of a civilized Indonesian society should be honed contiously.
MEMBACA FENOMENA KABAR BOHONG PILPRES 2019 DI INDONESIA BERDASARKAN KACA MATA HERBERT MARCUSE, JÜRGEN HABERMAS, DAN ZYGMUNT BAUMAN
Authors: Prasetyo Yohanes Wahyu
Published: December 2020

Abstract

Hoaxes were rampant before, during and after the 2019 presidential election. According to Herbert Marcuse’s point of view, the hoax phenomenon is closely related to capitalism, hence prioritizing profit gaining and ignoring truth. Consequently, the people are seen as things and objects. Further, according to Jürgen Habermas, the hoax phenomenon takes place because of lack of communicative dialog and ethical responsibility where mass media are used as weaponry means by political parties to make public opinions. In the meantime, Zygmunt Bauman is of the opinion that the hoax phenomenon demonstrates that the people are treated as outsiders, foreigners and the out-group
Clinical efficacy of the combined therapy of patients having urolithiasis using the Solidagoren
Authors: Д. В. Черненко  , В. В. Черненко
Published: December 2020

The article is dedicated to the problem of treating the patients with urolithiasis. The authors present the results after treatment the patients with residual concrements in the upper urinary tracts after extracorporeal shoch wave lithotripsy (ESWL), surgical extraction of calculi, contact lithotripsy. It was shown that the “Solidagoren” usage during 3 monthеs promotes passage of calculus remnants, normalizes hypercrystalluria, is well tolerated by patients, favours the restoration of functioning of an injured kidney.
Combined treatment of benign prostatic hyperplasia
Authors: О. О. Люлько  , О. О. Бурназ  , І. М. Нікітюк  , О. С. Сагань  , В. А. Депутат
Published: December 2020

The article described the modern state of relevance, diagnostics, treatment, clinical symptoms of benign prostatic hyperplasia (ВРН). Established that the transrectal microwave effect in combination therapy in patients with BPH achieves lasting results. This treatment has a positive clinical effect and lasting result of treatment of BPH in its initial stage.
SUSTAINABLE TOURISM DEVELOPMENT IN THE BACKWATERS OF SOUTH KERALA, INDIA: THE LOCAL GOVERNMENT PERSPECTIVE
Authors:   Christ College, Mahatma Gandhi University, Idukki, Kerala, India, JOSEPH Emilda K. , KALLARAKAL Tomy K. ,   School of Commerce, Finance and Accountancy, CHRIST (Deemed to be University), Bengaluru, Karnataka, India, VARGHESE Bindi ,   School of Business and Management, CHRIST (Deemed to be University), Bengaluru, Karnataka, India
Published: December 2020

Improper waste management continues to be a major challenge in the backwater destinations of South Kerala, India and the local government has been identified as a key player having a strong influence on sustainable tourism development initiatives in the destination. The study examines the major obstacles encountered while implementing sustainable tourism development practices in the backwater destinations of South Kerala, India. Qualitative data collected with the support of semi-structured interviews with top government officials of the Tourism Industry is used for the study. The findings from the study show that improper waste management affects sustainable tourism development in the backwater destinations, and that community involvement and community support are pre-requisites for implementing solid waste management practices in the backwater destinations of the state. The study also enlightens the roles of various stakeholders in waste management so as to develop a strong perspective of sustainable tourism development in the region.
Hypothesizing a New Standard for Environmental Injunctions
Authors: Murari Kalpana S.
Published: December 2020

Environmental litigation expands into economic activities that contribute to global warming and promotes inequitable distribution of natural resources. In the context of climate change litigation, international courts have consistently held that governments need to act on climate change and strive towards sustainable development. Courts are expected to act proactively and provide long-term solutions to environmental problems and address climate change impacts by ensuring compliance of legislative norms. Courts exercise discretionary powers when granting injunctive relief that provide a threshold for courts to intervene and guide economic activities of a nation towards sustainable development. Courts need to protect the legislative intent of the executive, preserve fundamental rights of parties not present before the court while preventing any injury to the defending party by protecting their rights under law or in equity. In the absence of statutory prescriptions for testing environmental harm, courts have established standards for granting interim relief, to ensure there is no abuse of powers to grant injunctions and that such orders are not set aside on grounds of abuse of judicial discretion. This paper prescribes a single, uniform and sufficient standard that calls for ‘Natural Capital’ accounting by federal agencies and private businesses that exploit natural resources for commercial purposes. Keywords: Environmental injunctions; Natural capital; Natural Capital accounting; Injunctive relief; Precautionary principle
POOR ACEH: THE IMPACT OF SPECIAL AUTONOMY AS EFFORT POVERTY REDUCTION IN ACEH
Authors: Setiawan Deni , Ulfa Khalida , Purwaningsih Titin
Published: December 2020

Special autonomy as one of the strategies in overcoming social welfare issues is one of them in Aceh Province. The implementation of regional autonomy after the reforms marked by the issuance of Law Number 33 of 2004 concerning the financial balance between the central government to the regions. The hope is to make the regions more autonomous or independent in government, and a more equal financial structure and the right to manage financial resources that are more transparent. This research focuses on the impact of the implementation of special autonomy in Aceh Province, limited from 2015 to 2019 in poverty alleviation efforts. This study uses a qualitative method with a descriptive approach to literature study and statistical data analysis. Data analysis techniques in this study were using statistical data analysis obtained from BPS. The results showed that special autonomy as an effort to reduce poverty in Aceh has a very good contribution because it has reduced poverty in Aceh from 819 thousand in March 2019 to 810 thousand people in September 2019. And the use of the special autonomy fund was channeled through programs made by the Aceh government in the fields of Education, Health, and the economy.
Determinação dos coeficientes de cultivo e a evapotranspiração real da cana-de-açúcar com o uso do modelo SAFER
Authors: Avilez Alberto Mario Arroyo , Hernandez Fernando Braz Tangerino , Galvão Ícaro Monteiro , Teixeira Antônio Heriberto de Castro
Published: December 2020

O conhecimento dos coeficientes de cultivo e da evapotranspiração das culturas é uma importante ferramenta para o planejamento agrícola em áreas irrigadas. Essas informações são utilizadas para determinar a demanda hídrica dos cultivos. O objetivo deste trabalho foi determinar os coeficientes de cultura através da relação ETr/ET0 nas diferentes fases fenológicas com a aplicação do modelo SAFER por meio do sensoriamento remoto. No cálculo da relação ETr/ET0 o comportamento da curva formada pelos valores determinados mostrou coerência com as curvas encontrados na literatura, entretanto os valores encontrados foram menores do que aqueles atualmente indicados.
Hilfer-Hadamard Fractional Differential Equations; Existence and Attractivity
Authors: Sİ BACHİR Fatima , SAİD Abbas , BENBACHIR Maamar , BENCHOHRA Mouﬀak
Published: December 2020

This work deals with a class of Hilfer-Hadamard differential equations. Existence and stability of solutions are presented. We use an appropriate fixed point
theorem.
MOTIVASI BERPRESTASI MAHASISWA DI MASA PANDEMI
Authors: KAMILA SYIFA'AN
Published: December 2020

Pada masa pandemi Covid-19 ini, pembelajaran dilakukan secara daring demi memutus rantai penyebaran Covid-19, sehingga mahasiswa dituntut untuk dapat lebih mandiri dalam belajar karena pembelajaran tidak dilakukan secara tatap muka. Pada masa ini, kemandirian belajar merupakan salah satu aspek penting yang harus dimiliki oleh mahasiswa demi tercapainya kompetensi pembelajaan secara optimal. Untuk mencapai kualitas pendidikan khususnya dalam kegiatan pembelajaran perlu menggunakan beberapa prinsip-prinsip pembelajaran yang telah ditetapkan. Bukan hanya dosen yang menyampaikan materi, namun mahasiswak juga ikut andil dalam mengikuti pembelajaran seperti diskusi, memberikan pendapat, memberi pertanyaan, dan lain-lain. Jika mutu pendidikan sudah baik maka motivasi belajar mahasiswa akan meningkat. Mahasiswa akan melakukan hal yang terbaik untuk setiap proses pembelajaran, kemungkinan besar juga akan berdampak pada hasil belajar mahasiswa yang akan lebih baik. Tujuan dari analisis ini adalah untuk mengetahui motivasi berprestasi mahasiswa di masa pandemi. Motivasi ini timbul karena adanya pengaruh dari luar mahasiswa, seperti: adanya ajakan, suruhan, bahkan paksaan dari orang lain, dengan demikian akan mahasiswa akan melakukan sesuatu untuk mencapai target belajar yang optimal.