bluuebunny/crossref_metadata_2025 huggingface dataset:
Cardiac phenylethanolamine N-methyltransferase: localization and regulation of gene expression in the spontaneously hypertensive rat
Authors: Peltsch Heather , Khurana Sandhya , Byrne Collin J. , Nguyen Phong , Khaper Neelam , Kumar Aseem , Tai T.C.
Published: October 2015

Phenylethanolamine N-methyltransferase (PNMT) is the terminal enzyme in the catecholamine biosynthetic pathway responsible for adrenaline biosynthesis. Adrenaline is involved in the sympathetic control of blood pressure; it augments cardiac function by increasing stroke volume and cardiac output. Genetic mapping studies have linked the PNMT gene to hypertension. This study examined the expression of cardiac PNMT and changes in its transcriptional regulators in the spontaneously hypertensive (SHR) and wild type Wistar-Kyoto (WKY) rats. SHR exhibit elevated levels of corticosterone, and lower levels of the cytokine IL-1β, revealing systemic differences between SHR and WKY. PNMT mRNA was significantly increased in all chambers of the heart in the SHR, with the greatest increase in the right atrium. Transcriptional regulators of the PNMT promoter show elevated expression of Egr-1, Sp1, AP-2, and GR mRNA in all chambers of the SHR heart, while protein levels of Sp1, Egr-1, and GR were elevated only in the right atrium. Interestingly, only AP-2 protein-DNA binding was increased, suggesting it may be a key regulator of cardiac PNMT in SHR. This study provides the first insights into the molecular mechanisms involved in the dysregulation of cardiac PNMT in a genetic model of hypertension.
Cosmic acceleration from varying masses in five dimensions
Authors: Moraes P. H. R. S.
Published: October 2015

Much effort has been made in trying to solve or at least evade the inconsistencies that emerge from general relativity as the framework for a cosmological model. The extradimensional models rise as superb possibilities in this regard. In this work, I present cosmological solutions for Wesson’s space–time–matter theory of gravity. A relation between mass variation at cosmological scales and the expansion velocity of the universe is obtained. Such a relation yields novel features on space–time–matter theory of gravity, which are carefully discussed.
Nonlinear System Identification Using Clustering Algorithm Based on Kernel Method and Particle Swarm Optimization
Authors: Ahmed Troudi , Mohamed Bouzbida , Abdelkader Chaari
Published: October 2015

Many clustering algorithms have been proposed in literature to identify the parameters involved in the Takagi–Sugeno fuzzy model, we can quote as an example the Fuzzy C-Means algorithm (FCM), the Possibilistic C-Means algorithm (PCM), the Allied Fuzzy C-Means algorithm (AFCM), the NEPCM algorithm and the KNEPCM algorithm. The main drawback of these algorithms is the sensitivity to initialization and the convergence to a local optimum of the objective function. In order to overcome these problems, the particle swarm optimization is proposed. Indeed, the particle swarm optimization is a global optimization technique. Thus, the incorporation of local research capacity of the KNEPCM algorithm and the global optimization ability of the PSO algorithm can solve these problems. In this paper, a new clustering algorithm called KNEPCM-PSO is proposed. This algorithm is a combination between Kernel New Extended Possibilistic C-Means algorithm (KNEPCM) and Particle Swarm Optimization (PSO). The effectiveness of this algorithm is tested on nonlinear systems and on an electro-hydraulic system.
Clustering Methods Based on Weighted Quasi-Arithmetic Means of T-Transitive Fuzzy Relations
Authors: Yang Miin-Shen , Wang Ching-Nan
Published: October 2015

In this paper we propose clustering methods based on weighted quasiarithmetic means of T-transitive fuzzy relations. We first generate a T-transitive closure RT from a proximity relation R based on a max-T composition and produce a T-transitive lower approximation or opening RT from the proximity relation R through the residuation operator. We then aggregate a new T-indistinguishability fuzzy relation by using a weighted quasiarithmetic mean of RT and RT. A clustering algorithm based on the proposed T-indistinguishability is thus created. We compare clustering results from three critical ti-indistinguishabilities: minimum (t3), product (t2), and Łukasiewicz (t1). A weighted quasiarithmetic mean of a t1-transitive closure [Formula: see text] and a t1-transitive lower approximation or opening [Formula: see text] with the weight [Formula: see text], demonstrates the superiority and usefulness of clustering begun by using a proximity relation R based on the proposed clustering algorithm. The algorithm is then applied to the practical evaluation of the performance of higher education in Taiwan.
A Finite Element Method for Inhomogeneous Deformation of Viscoelastic Dielectric Elastomers
Authors: Foo Choon Chiang , Zhang Zhi-Qian
Published: October 2015

Viscoelasticity is known to adversely affect the performance of a dielectric elastomer actuator and limit its application. In this paper, we present a finite element method for dielectric elastomers based on a nonlinear field theory that couples viscoelasticity and electrostatics. This method is implemented in a commercial finite element software. We use the method to solve electromechanical coupling problems of viscoelastic dielectric elastomers under inhomogeneous deformation in various configurations.
Flexural Vibration Characteristics of Micro-Rotors Based on the Strain Gradient Theory
Authors: Asghari Mohsen , Hashemi Mehdi
Published: October 2015

In this paper, the coupled three-dimensional flexural vibration of micro-rotors is investigated by taking into account the small-scale effects utilizing the strain gradient theory, which is a powerful nonclassical continuum theory in capturing small-scale effects. A micro-rotor consists mainly of a flexible micro-rotating shaft and a disk. With the aid of Hamilton's principle, governing equations of motion are derived and then transformed to the complex form. By implementing the Galerkin's method, a coupled ordinary differential equation is attained for the system. Expressions for the first two natural frequencies of the spinning micro-rotors are obtained with truncated two-term equation. Parametric studies on the results for different responses illustrate that the values of higher-order material constants may have significant effects on the natural frequencies of the system.
Cell-specific regulation of L-WNK1 by dietary K+
Authors: Webb Tennille N. , Carrisoza-Gaytan Rolando , Montalbetti Nicolas , Rued Anna , Roy Ankita , Socovich Alexandra M. , Subramanya Arohan R. , Satlin Lisa M. , Kleyman Thomas R. , Carattino Marcelo D.
Published: October 2015

Flow-induced K+secretion in the aldosterone-sensitive distal nephron is mediated by high-conductance Ca2+-activated K+(BK) channels. Familial hyperkalemic hypertension (pseudohypoaldosteronism type II) is an inherited form of hypertension with decreased K+secretion and increased Na+reabsorption. This disorder is linked to mutations in genes encoding with-no-lysine kinase 1 (WNK1), WNK4, and Kelch-like 3/Cullin 3, two components of an E3 ubiquitin ligase complex that degrades WNKs. We examined whether the full-length (or “long”) form of WNK1 (L-WNK1) affected the expression of BK α-subunits in HEK cells. Overexpression of L-WNK1 promoted a significant increase in BK α-subunit whole cell abundance and functional channel expression. BK α-subunit abundance also increased with coexpression of a kinase dead L-WNK1 mutant (K233M) and with kidney-specific WNK1 (KS-WNK1), suggesting that the catalytic activity of L-WNK1 was not required to increase BK expression. We examined whether dietary K+intake affected L-WNK1 expression in the aldosterone-sensitive distal nephron. We found a paucity of L-WNK1 labeling in cortical collecting ducts (CCDs) from rabbits on a low-K+diet but observed robust staining for L-WNK1 primarily in intercalated cells when rabbits were fed a high-K+diet. Our results and previous findings suggest that L-WNK1 exerts different effects on renal K+secretory channels, inhibiting renal outer medullary K+channels and activating BK channels. A high-K+diet induced an increase in L-WNK1 expression selectively in intercalated cells and may contribute to enhanced BK channel expression and K+secretion in CCDs.
Efficiency Evaluation for Smart Grid Management Based on Stochastic Frontier Model and Data Envelope Analyses Model
Authors: Xiaobao Yu , Zhongfu Tan , Kangting Chen , Liwei Ju , Puyu He
Published: October 2015

For the technical and allocative efficiency evaluation of smart grid, this paper has proposed two methods. One is based on Data Envelopment Analysis and another is based on Stochastic Frontier Model. Among them, the former considered the dynamics of smart grid development and development dynamics is the influence parameter. The latter analyzed self-duality between the Cobb-Douglas production function and cost function; then, it deduced the smart grid resources optimization allocative efficiency evaluation model which can avoid price information needs of input factor in conventional allocative efficiency evaluation. The validity and rationality of the two methods are verified by a case study.
Evaluation of the Anxiolytic and Antidepressant Activities of the Aqueous Extract fromCamellia euphlebiaMerr. ex Sealy in Mice
Authors: He Dongye , Wang Xitao , Zhang Ping , Luo Xinxing , Li Xiaoyu , Wang Lili , Li Shuying , Xu Yongping
Published: October 2015

Camellia euphlebiaMerr. ex Sealy is a traditional Chinese medicine that has been widely used for improvement of human emotions in the Guangxi Province of southern China. However, there are no studies about the anxiolytic and antidepressant activities ofCamellia euphlebia. This study evaluated the anxiolytic and antidepressant activities of the aqueous extract fromCamellia euphlebia(CEE) in mice. We found that administration of 400 mg/kg CEE or 20 mg/kg fluoxetine for 7 days significantly reduced the immobility time in both TST and FST. Oral administration of 100 mg/kg extract or 4 mg/kg diazepam for 7 days significantly increased the percentage of time spent and the number of entries into the open arms of the EPMT. In addition, the time spent by mice in the illuminated side of the LDBT was increased. Furthermore, pretreatment with 400 mg/kg CEE for 7 days significantly elevated the level of 5-HT and DA in the whole brain of mice. These results provide support for the potential anxiolytic and antidepressant activity ofCamellia euphlebiaand contribute towards validation of the traditional use ofCamellia euphlebiain the treatment of emotional disorders.
The Use of Project Time Management Processes and the Schedule Performance of Construction Projects in Mexico
Authors: Solís-Carcaño Rómel G. , Corona-Suárez Gilberto A. , García-Ibarra Aldo J.
Published: October 2015

Delays have been frequently reported as the cause of several conflicts that affect the different parties involved in construction projects. Project Time Management (PTM) includes a number of planning and controlling processes that are recommended for complying with requirements related to project time. The study reported in this paper aimed at assessing the use of PTM processes and its relation with project schedule performance (i.e., timely completion). Seven PTM processes and seventy-seven tasks associated with them were identified from the literature that is globally relevant to project management. The study included the assessment of fourteen school construction projects executed by a public agency in the Yucatan Peninsula, Mexico. These projects were monitored during the construction phase in order to measure two different variables: the use of processes related to PTM (i.e., schedule planning and controlling processes) and the project schedule performance. For each of these projects a Use Index was obtained for assessing the first variable, while the Schedule Performance Index and the Schedule Variance were computed to assess the second one. The results demonstrated there is statistical dependence between these two variables. Most of the projects that attained timely completion also made a greater use of the PTM processes.
Medical and Surgical Treatment in Pediatric Orbital Myositis Associated with Coxsackie Virus
Authors: Gil Pedro , Gil João , Paiva Catarina , Castela Guilherme , Castela Rui
Published: October 2015

Purpose.To report a case of orbital myositis associated with Coxsackie virus and its medical and surgical approach.Methods.Complete ophthalmological examination and imaging and analytical investigation were performed.Results. A 6-year-old male presented with subacute painless binocular horizontal diplopia. Examination revealed bilateral best-corrected visual acuity (BCVA) of 20/20 and right eye 45-prism-dioptre (PD) esotropia in near and distance fixations, with no motility restrictions. Serologic screening was positive for Coxsackie virus acute infection and computerized tomography (CT) suggested right eye medial rectus orbital myositis. An oral corticosteroid 1.0 mg/kg/day regimen was started. A new CT after two months showed symmetrical lesions in both medial rectus muscles. Corticosteroids were increased to 1.5 mg/kg/day. After imagiological resolution on the 4th month, alternating 45 PD esotropia persisted. Bilateral 7 mm medial rectus recession was performed after 1 year without spontaneous recovery. At 1-year follow-up, the patient is orthophoric with 200′′ stereopsis and bilateral 20/20 BCVA.Conclusions. To our knowledge, this is the first reported case of orbital myositis associated with Coxsackie virus. This is also the first reported case of isolated strabismus surgery after orbital myositis in pediatric age, highlighting the favourable aesthetic and functional outcomes even in cases of late ocular motility disorders.
Next-Generation Sequencing to Guide Clinical Trials
Authors: Siu Lillian L. , Conley Barbara A. , Boerner Scott , LoRusso Patricia M.
Published: October 2015

Rapidly accruing knowledge of the mutational landscape of malignant neoplasms, the increasing facility of massively parallel genomic sequencing, and the availability of drugs targeting many “driver” molecular abnormalities have spurred the oncologic community to consider how to use these new tools to improve cancer treatment. In order to assure that assignment of patients to a particular targeted treatment is likely to be beneficial to the patient, it will be necessary to conduct appropriate clinical research. It is clear that clinical (histology and stage) eligibility criteria are not sufficient for most clinical trials using agents that target mutations that are present in only a minority of patients. Recently, several clinical trial designs have been suggested to test the benefit of targeted treatment in molecular and/or clinical subgroups of patients. However, challenges remain in the implementation of such trials, including choice of assay, levels of evidence regarding gene variants, tumor heterogeneity, identifying resistance mechanisms, the necessity of screening large numbers of patients, infrastructure needs, and collaboration of investigators and industry. This article reviews current trial designs and discusses some of the considerations, advantages, and drawbacks of designing clinical trials that depend on particular molecular variants as eligibility criteria. Clin Cancer Res; 21(20); 4536–44. ©2015 AACR.

See all articles in this CCR Focus section, “Innovations to Speed Drug Development.”
Hepatic Arterial Infusion Chemotherapy for Advanced Hepatocellular Carcinoma with Portal Vein Thrombosis: Impact of Early Response to 4 Weeks of Treatment
Authors: Lin Chen-Chun , Hung Chien-Fu , Chen Wei-Ting , Lin Shi-Ming
Published: October 2015

Aim: The aim of the study was to investigate the impact of early response (ER) to hepatic arterial infusion chemotherapy (HAIC) on outcomes of patients with advanced hepatocellular carcinoma (HCC) complicated with major portal vein tumor thrombosis (PVTT). Methods: Thirty-nine patients receiving HAIC with low-dose cisplatin, 5-fluorouracil (5FU), and leucovorin were enrolled. One course of HAIC consisted of 5 days of treatment and 2 days rest per week for 4 consecutive weeks. ER was categorized as complete response, partial response, or minor response and was determined by World Health Organization criteria with dynamic computed tomography findings performed within 1 week after the first course of HAIC. Results: Thirteen (33%) patients achieved an ER. Twelve (92.3%) of these 13 ER patients achieved a higher overall response than all but one (3.8%) of the 26 non-early responders (NERs) (p<0.001). ER was the exclusive independent favorable factor for survival (p=0.003). Downstaging of tumors was noted in 76.9% of ERs, and these patients could proceed to locoregional therapies. ER patients subsequently had a higher 1-year survival (76.9% vs. 3.8%, p<0.001) and 6-month progression-free survival (PFS) (84.6% vs. 15.4%, p<0.001) than those for NERs. Only 8% of patients experienced grade 3 or higher toxicity during the first 4-week course of HAIC. Conclusions: HAIC can yield a satisfactory ER for advanced HCC with PVTT. Moreover, achievement of ER after HAIC in advanced HCC with PVTT is strongly associated with better overall survival and PFS.
Further insights into the anti-PF4/heparin IgM immune response
Authors: Jouni Rabie , Hackbarth Christine , Hietkamp Bernhard , Selleng Sixten , Koster Andreas , Jensch Inga , Linde Julia van der , Schwertz Hansjörg , Bakchoul Tamam , Hundt Matthias , Krauel Krystin , Schulze Annika , Greinacher Andreas
Published: October 2015

Anti-platelet factor 4 (PF4)/heparin antibodies are not only the cause of heparin-induced thrombocytopenia but might also play a role in the antibacterial host defence. Recently, marginal zone (MZ) B cells were identified to be crucial for anti-PF4/heparin IgG antibody production in mice. Combining human studies and a murine model of polymicrobial sepsis we further characterised the far less investigated anti-PF4/heparin IgM immune response. We detected anti-PF4/heparin IgM antibodies in the sera of paediatric patients < 6 months of age after cardiac surgery and in sera of splenectomised mice subjected to polymicrobial sepsis. In addition, PF4/heparin-specific IgM B cells were not only found in murine spleen, but also in peritoneum and bone marrow upon in vitro stimulation. Together, this indicates involvement of additional B cell populations, as MZ B cells are not fully developed in humans until the second year of life and are restricted to the spleen in mice. Moreover, PF4/heparin-specific B cells were detected in human cord blood upon in vitro stimulation and PF4-/- mice produced anti-PF4/heparin IgM antibodies after polymicrobial sepsis. In conclusion, the anti-PF4/heparin IgM response is a potential innate immune reaction driven by a B cell population distinct from MZ B cells.

Supplementary Material to this article is available online at www.thrombosis-online.com.
As ruas e as bobagens: anotações sobre o delirium ambulatorium de Hélio Oiticica
Authors: Dos Anjos Moacir
Published: October 2015

O artigo discute a centralidade da prática de deambular no Programa que Hélio Oiticica desenvolve a partir do início da década de 1960, embora somente ganhe maior evidência no final da década seguinte. Propõe o delirium ambulatorium como expressão mais radical do Parangolé, afirmando-o como proposta de emancipação do corpo não mais assistida por objetos e situações criados ou propostos pelo artista, mas, antes, deflagrada pelo embate direto e imediato com o mundo.
Anatomia de um Móvel Moderno: algumas questões em torno do Mobiliário da Casa Modernista, de Gregori Warchavchik
Authors: Simioni Ana Paula Cavalcanti
Published: October 2015

A afirmação da estética modernista no Brasil perpassa diversas práticas artísticas, entre elas o da decoração de interiores. De um modo geral, o protagonismo na introdução do design modernista no Brasil é atribuído ao suíço John Graz e ao ucraniano Gregori Warchavchik, dois imigrantes aportados no país em inícios da década de 19202. Sem contestar o papel que ambos desempenharam para a promoção de uma atualização do design de interiores, o presente artigo pretende analisar o mobiliário concebido por Gregori Warchavchik para a Casa Modernista procurando mostrar que esse, em sua materialidade, apresenta contradições que transparecem os impasses então vivenciados entre um certo ideário modernista almejado e as práticas concretas possíveis para sua realização na cidade de São Paulo em inícios do século XX.
Dossiê: Arte-Pesquisa: Inter-relações
Authors: Tavares Monica
Published: October 2015

Este dossiê da revista ARS reúne textos apresentados no evento ARTE_PESQUISA: INTER-RELAÇÕES promovido pelos três Programas de Pós-Graduação em Artes e Artes Visuais do Estado de São Paulo: o Programa de Pós-Graduação em Artes da UNESP, sob coordenação da Profª. Rejane Coutinho; o Programa de Pós-Graduação em Artes Visuais da USP, sob coordenação da Profª. Monica Tavares; e o Programa de Pós-Graduação em Artes Visuais da UNICAMP, sob coordenação do Prof. Mauricius Farina. ARTE_PESQUISA: INTER-RELAÇÕES pretendeu incentivar e estreitar o intercâmbio acadêmico entre os três programas de pós-graduação, ao mesmo tempo em que procurou aprofundar o debate sobre as pesquisas em desenvolvimento. Configurou-se como um fórum privilegiado de discussão acerca das relações entre a criação e a investigação em arte. Os eixos temáticos tratados foram os seguintes: Poéticas e Linguagens, História, Teoria e Crítica da Arte e Arte-educação.
De Rousseau ao Modernismo: ideias e práticas históricas do ensino do desenho
Authors: Iavelberg Rosa , De Menezes Fernando Chui
Published: October 2015

No presente artigo refletimos sobre a história particular do ensino do desenho – tratamos a passagem da visão tradicional à moderna e o olhar contemporâneo acerca do tema. Baseados no trabalho de pensadores como Ana Mae Barbosa, Arthur Efland, Juan Bordes e Elliot Eisner, buscamos situar e compreender as concepções que configuraram o ensino de desenho na história. Destacamos no estudo as implicações das ideias construídas historicamente no sentido de compreender e discutir os caminhos da educação em arte na contemporaneidade.
Yves Klein, Ícaro do modernismo
Authors: Torres Fernanda Lopes
Published: October 2015

Consideramos a obra de Yves Klein como uma (das últimas) poética(s) moderna(s) ao reconhecer a polaridade entre cor e vazio do monocromo junto ao tópos do instante. Apoiados no conceito de suddenness do crítico literário Karl-Heinz Bohrer, identificamos, entre a saturação máxima do azul e o vazio (emergência e potência da forma), experiência do presente absoluto equivalente à produção do novo. Nos anos 60, porém, esse coeficiente do novo começa a ser cada vez mais rapidamente apropriado pelo discurso cultural. Klein se apega então aos instantes que “insistem em nos abandonar” (Cioran) através de uma “farsa monocromo”.
Porque as águas dobram?
Authors: Vinci Leonardo da , Bagolin Luiz Armando
Published: October 2015

Derivam as águas dos rios do mar, não apenas se originam, pois os sentidos seguem como em torrente e quando algum deles se expõe explícito, escorrem os outros por baixo, em subterrâneos.
O Movimento de Arte Pornô: a Aventura de uma Vanguarda nos Anos 80
Authors: Kac Eduardo
Published: October 2015

O Movimento de Arte Pornô foi um movimento de arte experimental que iniciei no Rio de Janeiro e que durou, como um intervencionismo programático, por dois anos, de fevereiro de 1980 a fevereiro de 1982. Foi o último movimento de vanguarda organizado na arte e na poesia brasileiras. Também ficou conhecido como Poesia Pornô, Pornismo, ou Movimento Pornô ; neste artigo, usarei alternadamente os vários nomes desse movimento. O movimento realizou diversas intervenções públicas, editou três zines, duas antologias, diversos opúsculos e variadas publicações, e dirigiu-se a um público amplo1. O Pornismo começou como um movimento poético e rapidamente expandiu-se para outras áreas, subvertendo as normas estéticas em diferentes meios, desestabilizando as convenções que regem a experiência cotidiana e dando forma a novos modos de ser e estar no mundo.
Obras à mostra: articulações do trabalho de arte pelo desenho de exposição
Authors: Menotti Gabriel
Published: October 2015

Esse artigo examina processos tradicionalmente envolvidos nas práticas curatoriais e a maneira pela qual estas se definiriam historicamente em contraposição ao gesto artístico. Serão delineadas as origens institucionais da curadoria, a renegociação do papel do curador durante o modernismo e algumas perspectivas contemporâneas sobre a curadoria independente. Nesse percurso, analisaremos como projetos de exposição realizados tanto por curadores quanto por artistas contribuem ativamente na produção de trabalhos artísticos e na consolidação de determinadas técnicas e linguagens. Por fim, procuraremos sustentar que as práticas curatoriais constituem uma forma de design, podendo ser mais bem compreendidas em termos de arranjos expositivos (exhibition designs).
Dimensões comunicacionais no conceito de escultura social de Joseph Beuys como possibilidade de tradução criativa
Authors: Vicini Magda Salete
Published: October 2015

O presente artigo é resultado de pesquisa de doutorado em Comunicação e Semiótica, realizada na PUC-SP, sobre o conceito de Escultura Social na obra de Joseph Beuys, com recorte em pesquisadores como Matthias Bunge e Caroline Tisdall, bem como a influência dos filósofos românticos Schiller, Goethe, Hegel e de Novalis na construção deste conceito na obra de Rudolf Steiner. O contexto da arte é abordado através de críticos de arte que analisam o trabalho artístico de Beuys, cujas características comunicacionais são apresentadas em relação a Humberto Maturana e Francisco Varella e à crítica da comunicação. Finalmente, o artigo aborda a possibilidade de tradução criativa (Walter Benjamin, Georg Steiner e Haroldo de Campos) deste conceito de Joseph Beuys.
O cinema e a imagem verdadeira
Authors: Jorge Marina Soler
Published: October 2015

Este artigo procura analisar a questão ontológica no cinema conforme teorizada por André Bazin a partir de novas pesquisas em História da Arte desenvolvidas por Hans Belting. Com os escritos deste autor, veremos que a crença na imagem cinematográfica ultrapassa o suporte técnico e sua gênese mecânica, conforme colocava Bazin, e tem sua origem na cultura do Cristianismo que difunde a crença na imagem como prova da existência do Salvador, estabelecendo desta maneira uma identificação entre suporte material, representação e realidade que repercutirá no cinema.
Vibrações possíveis: Arte/Educação e Saúde Mental na Contemporaneidade
Authors: Avers Paula Carpinetti
Published: October 2015

O artigo pretende desenvolver a ideia que a Arte/Educação, campo do universo artístico que se dedica aos fundamentos históricos, filosóficos e metodológicos do ensino das artes, pode ser um recurso importante para articular arte e Saúde Mental na contepmporaneidade, ao oferecer o contato rico e substancioso com as artes, favorece a experiência estética e as condições de enlace social; alinhando-se; desta forma, às propostas da Reforma Psiquiátrica brasileira.
Livro/Acervo, Para Além do Arquivo e Arquivo Vivo: uma trilogia possível
Authors: Arantes Priscila
Published: October 2015

Livro/Acervo, Para Além do Arquivo e Arquivo Vivo: uma trilogia possível discute as modificações no conceito de arquivo no contexto atual tomando como ponto de partida a cultura e a arte contemporânea. Analisa, ainda, três projetos curatoriais desenvolvidos no Paço das Artes que dialogam com o tema em questão.
Jackson Pollock e a descoberta do inconsciente na arte americana do pós-guerra
Authors: Silva Sara Gomes da
Published: October 2015

Este artigo situa Jackson Pollock, uma das figuras mais importantes do Expressionismo Abstrato, no quadro do debate, caraterístico dos anos 1950 e 1960, sobre a relação entre arte e vida. Analiso, nesse contexto, os limites da crítica face a um pintor que nos deixou inúmeros testemunhos sobre o papel do inconsciente no seu processo criativo. Qual o lugar reservado pela crítica, à época, para essa via de interpretação? Procurando responder a essa questão, o artigo põe em confronto as diversas perspectivas dos críticos e relaciona-as com a reflexão de Pollock sobre si mesmo.
Falsa interface como recurso poético na obra interativa
Authors: Sogabe Milton Terumitsu
Published: October 2015

O conceito de “falsa interface” nasce da observação e produção de instalações interativas mediadas pela tecnologia digital. A “falsa interface” não é uma interface tecnológica que permite ao público a interação com um sistema digital, mas é um recurso poético, geralmente um aparato ou objeto artesanal com o qual o público interage com a obra de arte, que é um sistema. A “falsa interface” apresenta uma relação física, uma conexão com uma interface tecnológica. O público se relaciona ludicamente com a falsa interface e a interface tecnológica passa despercebida, em segundo plano, embora seja ela que capte e envie para o sistema a atuação do público.
A-thing: body-animal, body-device, body-thing
Authors: Carvalho Agda , Paraguai Luisa
Published: October 2015

This paper is concerned with the a-thing project (2013) and its discussions about body's singularities, tracking the visceral data to amplify bodily noises and to represent them as the information visualisation in the space. The wearable artefact presents itself in three different situations of use and contexts of significance named as “body-animal”, which organizes material attributes of shape by changing the silhouette and reordering the body; “body-device”, which captures physiological data; and “body-thing” that evokes modes of perception and process of individuation, considering that the user/performer can inhabit a-thing and recognise different spaces.
Audiovisuality of the mist: video-cliffs vs video-clips
Authors: Rincón Omar , Tono Lina
Published: October 2015

Transparency is the value of our time: Political transparency as a democratic principle. Visual transparency on the digital. Body transparency as aesthetics of seduction. This essay-creation claims that, from and on audiovisual, the visual transparency is an explicit way to conceal, hide, losing the polysemy of images. And proposes the ambiguous of the visible, the dirty look, the bastard identities as a creative tactic to reach narrative, aesthetics, truth and audiovisual representation. Thus, the figure of the fog as in-between visibility gain power to intervene the digital and television transparency. This essay-creation seeks to rethink the visual aesthetics and audiovisual narrative through the figure of the mist. At the end, it propose the video-cliff format (or narrative vertigo over the fog) as impure alternative that breaks the transparency of the our vide-clip era.
From comics to the museum: the democratization of information in arts for children
Authors: Carvalho Cristina , Lopes Thamiris Bastos , Cancela Clarisse Duarte Magalhães
Published: October 2015

The article discusses works of art for children in museums, understood as informational devices that should extract information from their collections in order to generate knowledge for different audiences. From the cartoonist Mauricio de Souza's initiative in transforming his comic book characters into works of art for museum spaces, and based on Wallon’s perspective on child development, we discuss the inclusion of children in art museums and the possibilities of developing educational activities able to include this specific audience.
Producing Miss Saigon
Authors: Keith Jeffrey A.
Published: October 2015

This essay examines Western representations of Saigon as a feminine and sensual place, providing examples of continuity between French colonial portrayals of the city and print journalism during the u.s. presence in Vietnam from the mid-1950s to 1975. Femininity and sexual allure feature prominently in an array of 19th Century works about Saigon, yet those writings vary considerably. By the early 20th Century, Western writers had begun to personify Saigon as a woman engaged in a relationship with a Western man. In similar ways, femininity and sensuality figured prominently in how Western journalists covered Saigon throughout the Vietnam War. Such representations cast a mold for tragic postwar narratives—a genre that the celebrated musical Miss Saigon best exemplified. Weighing the possibilities and shortcomings of collectively interpreting these writings as an Orientalist discourse, this article surveys more than a century of work that describes Saigon as a sensual maiden whom the West courted, exploited, and abandoned.
New combinations for East European species of Sabulina (Caryophyllaceae)
Authors: Mosyakin Sergei L. , Fedoronchuk Mykola M.
Published: October 2015

Recent molecular studies (Greenberg & Donoghue 2011, Dillenberger & Kadereit 2014) clearly demonstrated that the genus Minuartia Linnaeus (1753: 89) (Caryophyllaceae Juss.) is highly polyphyletic and the taxa previously placed in that genus (e.g., McNeill 1962, Halliday 1993) represent several distinct phylogenetic lineages less related to each other than to some other readily recognized Caryophyllaceae genera. As a consequence, many taxa, which were earlier treated in Minuartia, should be now placed in several distinct genera. Dillenberger & Kadereit (2014) proposed to recognize within the former Minuartia s.l. several genera which are supported by both morphological and molecular characters. Three genera, Mcneillia Dillenberger & Kadereit (2014: 83), Minuartiella Dillenberger & Kadereit (2014: 84), and Pseudocherleria Dillenberger & Kadereit (2014: 84), were described as new ones. Resurrection and re-circumscription was proposed for previously neglected genera Cherleria Linnaeus (1753: 425), Facchinia Reichenbach (1841: 63), Mononeuria Reichenbach (1841: 118), Rhodalsine J. Gay (1845: 25), Sabulina Reichenbach (1832: 24), and Triplateia Bartling (1830: 305), as well as re-circumscription of Minuartia sensu stricto and Eremogone Fenzl (1833: 13). A key to the new proposed classification and a nomenclatural synopsis of the currently recognized species were provided as well (Dillenberger & Kadereit 2014). Accordingly other authors already validated additional nomenclatural combinations in Eremogone (Rabeler & Wagner 2015), Mcneillia (Bartolucci et al. 2015), and Sabulina (Iamonico 2014).
Three new species, two newly recorded species and one newly recorded genus of Lithocolletinae (Lepidoptera: Gracillariidae) from China
Authors: BAI HAIYAN , XU JIASHENG , DAI XIAOHUA
Published: October 2015

The Chinese representatives of the genera Chrysaster Kumata and Cameraria Chapman (Gracillariidae: Lithocolletinae) were studied. Chrysaster is recorded for the first time in China. Three species belonging to Cameraria, C. diplodura Bai, sp. nov., C. rhynchophysa Bai, sp. nov. and C. jiulianshanica Bai, sp. nov., are described as new. Chrysaster hagicola Kumata and Cameraria magnisignata Kumata are new records for China. Adults and genitalia of the five species are illustrated. A key to the Chinese species of Cameraria is provided.
Life among crevices: osteology of Nannophrys marmorata (Anura: Dicroglossidae)
Authors: SENEVIRATHNE GAYANI , MEEGASKUMBURA MADHAVA
Published: October 2015

Nannophrys Günther, 1868, a group of flat-bodied frogs, is an endemic Sri Lankan genus bearing three extant and one extinct species, adapted to live among narrow and horizontal rock crevices adjacent to clear water streams. One of these species, Nannoprhys marmorata Kirtisinghe, 1946 is mostly restricted to the rock strewn streams of the Knuckles region (200–1200 m asl). Here, we re-describe the osteology of Nannophrys marmorata highlighting apomorphies and adaptations for life between narrow spaces. Previous studies on skeletal morphology of the genus Nannophrys include Gunther (1869), Boulenger (1882, 1890), Noble (1931), Kirtisinghe (1946), Clarke (1983) and Scott (2005). Basic descriptions of the skeleton of N. marmorata have been done (Kirtisinghe 1946; Clarke 1983), on which we build and elaborate. We describe the osteology using three adult specimens (SVL= 35.2–36.5 mm) of N. marmorata, stained differentially for bone and cartilage following the procedure by Taylor and Van Dyke (1985); we follow the osteological terminology of Trueb (1973), Duellman and Trueb (1986), and Pugener and Maglia (1997, 2009).
Platybracon Yang et al. (2008) (Hymenoptera: Braconidae), junior homonymy and subjective synonymy—a systematic and nomenclatural note
Authors: KITTEL REBECCA N. , QUICKE DONALD L. J.
Published: October 2015

Yang et al. (2008) described a distinctive, small braconine wasp, Platybracon sinicus, from China as a new genus and new species. They discussed similarities with other braconine genera and to which genus it would belong to when using the only available key to the Braconinae (Quicke, 1987). However, they failed to notice that their genus name Platybracon would be a junior homonym of Platybracon Szépligeti, 1900. Additionally, Platybracon is itself a junior subjective synonym of Chaoilta Cameron 1899, also a member of the Braconinae, synonymised by Baltazar, 1966 and upheld by Quicke (1987). Platybracon sinicus described by Yang et al. does not belong to the genus Chaoilta, which belongs to the Aphrastobraconini (sensu van Achterberg 1989) but instead is a member of the Plesiobracon genus group of the Braconini.
The tadpole of Hylodes meridionalis (Mertens, 1927), a lotic stream anura from the Atlantic Rainforest of Brazil
Authors: Nogueira-Costa Paulo , Wachlevski MILENA
Published: October 2015

The genus Hylodes Fitzinger, 1826, comprises 25 species (Sá et al. 2015), of small to medium-sized diurnal frogs, that habit lotic stream habitats of the Atlantic Rainforest domain. Only 17 species of Hylodes genus had its larvae described so far (Costa et al. 2010; Sá et al. 2015). Regarding the osteology, only one species has its chondrocranium described (Bilate et al. 2012). Herein we describe the tadpole of H. meridionalis and its osteology.
Two new species of the genus Loxopamea Hreblay & Plante 1995 (Lepidoptera: Noctuidae) from China
Authors: GYULAI PETER , SALDAITIS AIDAS
Published: October 2015

The genus Loxopamea Hreblay & Plante, 1995 (Noctuidae, Xyleninae: Apameini) was erected by Hreblay & Plante (1995) with type species Loxopamea albitracta Hreblay & Plante, 1995, comprises seven known species with very restricted range in Himalayan–Sino-Pacific subregions. Recently a detailed revision of the tribe Apameini, including the genus Loxopamea was elaborated by Zilli et al. (2009). Taxonomic nomenclature used in this study is constituted according to that revision. In 2014 two further species of the genus were discovered in Sichuan Province of China during a zoological expedition by A. Floriani & A. Saldaitis, which were recognized as new to science. The descriptions of the new species are presented below.
Tydeus shabestariensis sp. nov. and description of the male of Neopronematus sepasgosariani (Acari: Tydeoidea), with a key to the Iranian species of Tydeus
Authors: AKBARI ALI , IRANI-NEJAD KARIM HADDAD , KHANJANI MOHAMMAD , ARZANLOU MAHDI , KAŹMIERSKI ANDRZEJ
Published: October 2015

A new species of the family Tydeidae from Iran, Tydeus shabestariensis sp. nov., is described from adult males and females collected from soil in apple orchards. A key to species of Tydeus of Iran, based on females, is provided. The male of Neopronematus sepasgosariani (Tydeoidea: Iolinidae) is also described and illustrated for the first time.
Endecous peruassuensis n. sp. (Orthoptera: Grylloidea: Phalangopsidae)
from caves of Eastern Brazil: evidence of isolation in the subterranean realm and discussion about troglomorphisms
Authors: BOLFARINI MARCIO P. , BICHUETTE MARIA ELINA
Published: October 2015

We describe a new species of the genus Endecous Saussure (1878), recorded at the Lapa do Cipó and Olhos d’Água caves, which are located in the Itacarambi municipality, Minas Gerais state, Eastern Brazil. Another species, E. aguassay Mews, 2008 was recordedin the surroundings of the caves. The genus Endecous corresponds to the most common cricket in Brazilian hypogean environments. In general, these crickets inhabit the areas around cave entrances up to the aphotic zones of caves. The genus Endecous is the only cave cricket to present troglobiomorphosis, i.e., an apterous condition. The distribution of the new species is limited to these two caves, which suggests an endemism in this karst system similar to the distribution of other endemic animals, such as harvestmen and amblypygid arachnids. This species is the sixth troglobitic one described for Olhos d’Água cave, which sets this cave as a spot of subterranean fauna in Brazil.
Clustering of Regional-Scale Extreme Precipitation Events in Southern Switzerland
Authors: Barton Yannick , Giannakaki Paraskevi , von Waldow Harald , Chevalier Clément , Pfahl Stephan , Martius Olivia
Published: October 2015

Temporal clustering of extreme precipitation events on subseasonal time scales is of crucial importance for the formation of large-scale flood events. Here, the temporal clustering of regional-scale extreme precipitation events in southern Switzerland is studied. These precipitation events are relevant for the flooding of lakes in southern Switzerland and northern Italy. This research determines whether temporal clustering is present and then identifies the dynamics that are responsible for the clustering.

An observation-based gridded precipitation dataset of Swiss daily rainfall sums and ECMWF reanalysis datasets are used. Also used is a modified version of Ripley’s K function, which determines the average number of extreme events in a time period, to characterize temporal clustering on subseasonal time scales and to determine the statistical significance of the clustering. Significant clustering of regional-scale precipitation extremes is found on subseasonal time scales during the fall season.

Four high-impact clustering episodes are then selected and the dynamics responsible for the clustering are examined. During the four clustering episodes, all heavy precipitation events were associated with an upper-level breaking Rossby wave over western Europe and in most cases strong diabatic processes upstream over the Atlantic played a role in the amplification of these breaking waves. Atmospheric blocking downstream over eastern Europe supported this wave breaking during two of the clustering episodes. During one of the clustering periods, several extratropical transitions of tropical cyclones in the Atlantic contributed to the formation of high-amplitude ridges over the Atlantic basin and downstream wave breaking. During another event, blocking over Alaska assisted the phase locking of the Rossby waves downstream over the Atlantic.
Store-operated calcium entry and diabetic complications
Authors: Chaudhari Sarika , Ma Rong
Published: October 2015

Store-operated Ca2+ entry (SOCE) is mediated by the store-operated Ca2+ channel (SOC) that opens upon depletion of internal Ca2+ stores following activation of G protein-coupled receptors or receptor tyrosine kinases. Over the past two decades, the physiological and pathological relevance of SOCE has been extensively studied. Recently, accumulating evidence suggests associations of altered SOCE with diabetic complications. This review focuses on the implication of SOCE as it pertains to various complications resulting from diabetes. We summarize recent findings by us and others on the involvement of abnormal SOCE in the development of diabetic complications, such as diabetic nephropathy and diabetic vasculopathy. The underlying mechanisms that mediate the diabetes-associated alterations of SOCE are also discussed. The SOCE pathway may be considered as a potential therapeutic target for diabetes-associated diseases.
Prospective analysis of antigen-specific immunity, stem-cell antigens, and immune checkpoints in monoclonal gammopathy
Authors: Dhodapkar Madhav V. , Sexton Rachael , Das Rituparna , Dhodapkar Kavita M. , Zhang Lin , Sundaram Ranjini , Soni Sonal , Crowley John J. , Orlowski Robert Z. , Barlogie Bart
Published: October 2015

Key Points

Prospective analysis of antigen-specific B/T-cell immunity in natural history of human premalignancy. Stemness antigens and ICPs may be targets for cancer prevention.
Metabolic activation of mitochondria in glioma stem cells promotes cancer development through a reactive oxygen species-mediated mechanism
Authors: Yuan Shuqiang , Lu Yunxin , Yang Jing , Chen Gang , Kim Sangbae , Feng Li , Ogasawara Marcia , Hammoudi Naima , Lu Weiqin , Zhang Hui , Liu Jinyun , Colman Howard , Lee Ju-Seog , Li Xiao-Nan , Xu Rui-hua , Huang Peng , Wang Feng
Published: October 2015

Introduction

Cancer stem cells (CSCs) possess characteristics associated with normal stem cells, specifically the abilities to renew themselves and to give rise to all cell types (differentiation). It is assumed that induction of differentiation in CSCs would reduce their ability to form tumors. What triggers CSC differentiation and the role of “differentiation” in tumorigenesis remain elusive.

Methods

Glioma stem cell (GSC) lines and subcutaneous as well as orthotopic xenografts established from fresh surgical specimens of glioblastoma multiforme were used.

Results

Exposure of GSCs to serum activates mitochondrial respiration and causes an increase in mitochondrial reactive oxygen species (ROS) as well as oxidative stress responses, leading to the appearance of differentiation morphology and a deceased expression of CSC markers. Chemical perturbation of the mitochondrial electron transport chain causes ROS increase and further downregulation of stem cell markers, while antioxidant N-acetyl-cysteine reduces ROS and suppresses the differentiation of GSCs. Surprisingly, the serum-induced differentiated GSCs exhibit greater ability to form tumor in both orthotopic and subcutaneous xenograft models, which can be suppressed by N-acetyl-cysteine. Mitochondrial ROS from the serum-stimulated cells triggered the activation of nuclear factor-kappa-B (NFκB) pathway, which is a potential mechanism for the promotion of tumorigenesis.

Conclusion

This study suggests that ROS generated from active mitochondrial respiration in the presence of serum is critical in CSCs activation, which promotes tumor development in vivo.