bluuebunny/crossref_metadata_2025 huggingface dataset:
Identidad y localidad en los nombres personales indígenas. Sakaka en el siglo XVII
Authors: Medinaceli Ximena
Published: April 2023

¿CÓMO SE LLAMABAN LAS PERSONAS de una comunidad indígena a comienzos de la Colonia y qué significado tienen estos nombres? Nos preguntamos si es posible, a través de ellos, conocer algo más de aquellos tiempos de particular importancia. Entendemos que los nombres personales son un bien simbólico, propio e individual, que se articula de manera compleja con una tradición cultural de larga data. Son, en definitiva, parte de los símbolos colectivos que ha construido una sociedad para identificar y, tal vez, clasificar a las personas; por lo tanto, su estudio permitirá el acercamiento a percepciones, prioridades, preocupaciones y formas de relación entre los hombres y la sociedad, así como con el cosmos .. Este trabajo, por tanto, tiene como telón de fondo una propuesta metodológica que plantea que el estudio de los nombres personales es una vía para estudiar aspectos de algo tan cercano y, a la vez, tan escurridizo como la identidad.
Quilcar los indios: a propósito del vocabulario minero andino de los siglos XVI y XVII
Authors: Salazar-Soler C.
Published: April 2023

En este trabajo, nuestra aproximación a una historia cultural de las minas andinas se realizará a través del estudio del lenguaje: revelador privilegiado del contacto entre los dos mundos. 1 Nos limitaremos al análisis de tres fuentes: la Relación General de la Villa Imperial de Potosí de Luis Capoche de l 5 85, el primer diccionario de términos mineros andinos: el Diccionario de García de Llanos de l 6 l l, y el manual de minería y metalurgia más importante del Renacimiento, El arte de los metales, de Alvaro Alonso Barba, publicado en Madrid en l 640. Estas obras fueron elaboradas en el Virreinato del Perú y están centradas en el centro minero más importante de la época: el Cerro Rico de Potosí.
SOCIAL MEDIA, ISLAMIC FINANCIAL LITERACY, AND ISLAMIC BANKING PRODUCT OWNERSHIP: A MODERATING MODEL
Authors: Lutfi Lutfi , Prihatiningrum Vita
Published: April 2023

The role of social media and Islamic financial literacy is critical in influencing the consumer to have Islamic financial products. However,  no studies on this topic have been conducted in Indonesia. The use of social media by a millennial is snowballing. This study examines the impact of social media, represented by the attractiveness of influencers and social media engagement, on the intention to own Sharia banking investment products among the millennial generation. This study also examines the role of Islamic financial literacy and income as independent and moderating variables. Data is collected using purposive sampling, followed by convenience sampling through a Google form questionnaire distributed to the social media users of Gen Z in the Surabaya agglomeration area. This study used 216 questionnaires and analyzed them using Partial Least Square - Structural Equation Model (PLS-SEM). The results show that influencer attractiveness, social media engagement, and Sharia financial literacy positively influence millennials' ownership intention of Islamic banking investment products. Islamic financial literacy weakens influencer attractiveness's impact on the ownership intention of Islamic banking investment products, while income does not moderate the relationship. Furthermore, social media engagement is most significant in determining product ownership intentions. The practical implication of the findings suggests the importance of Islamic banks to encourage more engagement of their social media users by providing useful information about bank products. This research provides a theoretical contribution to the theory of consumer behavior and social media that using social media is one of the most effective ways of influencing consumer purchasing decisions.
The Role of Legal Clinics in Promoting Human Rights: The Experience of Nigeria Law School Yenagoa Law Clinic and The Legal Support and Care Centre at GD Goenka University School of Law Gurgaon India
Authors: Odigie-Emmanuel Omoyemen Lucia , Dahiya Shiksha
Published: April 2023

Legal clinics are playing a very prominent role in promoting human rights and filling global access to justice gaps through justice education. In turn, they provide access to justice for the poor and marginalized in fulfilment of this social justice mandate. Clinicians realize that human rights and justice education is key to their social justice mission. Apart from adding statements about the importance of justice to their mission statement, clinics have in place programs fundamentally oriented around a vision of justice. Students in clinics play very important roles in achieving their clinics’ social justice mission and goals by sensitizing youths, women, children, inmates and citizens to change thought processes and mold the social fabric needed for a just society, promoting a culture of lawfulness through generating solutions to several social issues that results in good citizenship, improved policies, good governance, access to justice and effective remedies. Generally, the objective of this paper is to share case studies from the Nigerian Law School Yenagoa Legal Clinic, the Legal Support and Care Centre at GD Goenka University and Legal Aid Society at The NorthCap University, Gurugram, Haryana, India of how legal clinics are promoting human rights, access to justice, a culture of lawfulness and sustainable development through their work in communities, schools and prisons. The first section lays a background on the role of law in shaping society, the second focuses on the conceptual and theoretical frameworks. The third section examines the framework that provides the mandate education for justice and human rights. The fourth section assesses the role of law schools and clinics in promoting education for justice, human rights and a culture of lawfulness while the fifth section deals with conclusions and recommendations.
The Abolition of Sex/Gender Registration in the Age of Gender SelfDetermination: An Interdisciplinary, Queer, Feminist and Human Rights Analysis
Authors: Decoster Ariël , Cannoot Pieter
Published: April 2023

It is commonly accepted that gender matters (whether cisgender, transgender/trans*, gender non-binary, genderfluid, gender queer, agender, or other) and many are raising awareness about the fact that gender always seems to matter. That gender matters, and always matters, does not necessarily mean, however, that gender needs to be authenticated or endorsed by the state.

In fact, based on a feminist and queer reading of human rights, this interdisciplinary article asserts that state-sponsored sex/gender assignment through the practice of sex/gender registration must halt. It argues that mandatory (binary) sex/gender registration disproportionately infringes the emerging right to gender identity autonomy and the right to the legal recognition thereof. Most often, our Western heterosexual cultural system of gender, which posits the existence of two oppositional and complementary gender identities, anchored in so-called natural and binary sex, goes hand in hand with material and discursive forms of violence and entails various forms of unequal power dynamics. Hegemonic in nature, the heterosexual cultural system of gender pervasively regulates many (if not every) aspects of all bodies’ lives and being, including by legal means. The law upholds and certifies that specific gender regime, inter alia, by assigning a sex to individuals at birth (through the registration of a claimed evident, objective, natural element to be found on or in the body by inspection). Policies of mandatory (binary) sex/genderregistration therefore constitute the cornerstone of the legalisation of the heterosexual cultural system of gender, which produces not only the conventional feminine and masculine gender identity (i.e. women and men) but also sex (i.e. females and males).

This article suggests that, as long as the law refuses to go beyond the compulsory male/female (or even male/female/other) framework, it will be complicit in upholding the undesired consequences of the heterosexual cultural system of gender, which affect all persons of whatever gender or physical features. Therefore, undoing remaining forms of global gender injustice, as well as respecting, protecting and fulfilling human rights relating to gender identity, requires the abolishment of sex/gender registration instead of expanding the available gender markers. Indeed, this article finds that current state practices do not pursue a legitimate aim, and even if they do, mandatory sex/gender registration does not pass the proportionality test that is required in the assessment of restrictions of fundamental rights. A human rights analysis of official sex/gender in the age of gender self-determination finds mandatory sex/gender registration to be a disproportionate measure and recommends that states change their current practices. Doing so would be beneficial to cisgender and trans* individuals alike.
From the Field: Law-Related Education as a Branch of Civics Education in the United States
Authors: Ward Latia
Published: April 2023

Law-related education is “education to equip nonlawyers with knowledge and skills pertaining to the law, the legal process and the legal system, and the fundamental principles and values on which these are based.” Law-related education is a branch of civics education although there is overlap between law-related topics and civics topics because both areas include the study of the Bill of Rights, the study of the function of government institutions, and the study of one’s rights with respect to voting, jury duty, etc. Often, the terms law-related education and civics education are used interchangeably. However, there is a trend for law-related education to be associated with violence prevention. In this article, I provide an overview of the origin of law-related education, a discussion of a law-related education program that I developed for K-12 students, my reflections on implementing the program, key resources that I found during my planning, an overview of state laws that address K-12 law-related and civics education requirements, an analysis of North Carolina’s civics education requirement, and an overview of civics education programs outside the K-12 classroom.
The Journey To Legal Capability: Challenges for Public Law from Public Legal Education
Authors: Olatokun Abiodun Michael
Published: April 2023

Citizens whose rights are infringed by a public authority are often unable to attain a court judgment to challenge those adverse decisions. The trite explanation is the most compelling; judicial review is a prohibitively expensive process. This high cost of litigation combined with the fees charged by public lawyers can make fighting for one’s legal rights inaccessible to those without independent means or publicly funded legal representation. There is no question that this is a complete explanation for many instances of unmet legal need, but this paper seeks to raise another important barrier to access to justice that is seldom discussed in the recent literature.

Legal capability is defined as the knowledge, skills and confidence required to participate in legal systems and to deal with one’s legal issues. It is thought to be improved through programmes of Public Legal Education (PLE). Whilst the author reiterates that legal education is no replacement for state-funded legal advice for the poor, PLE is a crucial tool in helping people to challenge public decision making.
Enhancing the Measurement of Sentence Severity through Expert Knowledge Elicitation
Authors: Pina-Sanchez Jose , Gosling John Paul
Published: April 2023

Quantitative research on judicial decision-making faces the methodological challenge of analysing disposal types that are measured in different units (e.g. money for fines, days for custodial sentences). To overcome this problem a wide range of scales of sentence severity have been suggested in the literature. One particular group of severity scales that has achieved high validity and reliability are those based on Thurstone’s pairwise comparisons. However, this method invokes a series of simplifying assumptions, one of them being that the range of severity covered by different disposal types is constant. We undertook an expert elicitation workshop to assess the validity of that assumption. Responses from the six criminal law practitioners and researchers that participated in our workshop unanimously pointed at severity ranges being highly variable across disposal types (e.g. much wider severity ranges were identified for suspended custodial sentences than for fines). We used this information to re-specify Thurstone’s model allowing for unequal variances. As a result, we obtained a new, more robust, scale of sentence severity.
Aerodynamic Shape, Scaling Law of Drag and Terminal Speed of the Dandelion
Authors: Sun Bohua , Guo Xiao-Lin
Published: April 2023

The common dandelion uses a bundle of drag-enhancing bristles (the pappus) that enables seed dispersal over formidable distances; however, the scaling laws of aerodynamic drag underpinning pappus-mediated flight remains unresolved. In this paper, we study the aerodynamic shape of dandelion, derive the scaling law of resistance, determine the Vogel exponent. In particular, we find that the total drag coefficient is proportional to the -2/3 power of the dandelion pappus Reynolds number, and obtain the terminal velocity of the dandelion seed under gravitation field.
Current Applications of Liposomes for the Delivery of Bioactives: A Review on the Encapsulation of Vitamins
Authors: Chaves Matheus A. , Ferreira Letícia S. , Baldino Lucia , Pinho Samantha C. , Reverchon Ernesto
Published: April 2023

Liposomes have been used for several decades for the encapsulation of drugs and bioactives in cosmetics and cosmeceuticals. On the other hand, the use of these phospholipid vesicles in food applications is more recent and has been increasing significantly in the last ten years. Although in different stages of technological maturity - in the case of cosmetics, many products are on the market - processes to obtain liposomes suitable for the encapsulation and delivery of bioactives are highly expensive, especially aiming at scaling-up. Among the bioactives proposed for cosmetics and food applications, vitamins are the most frequently used. Despite the differences between the administration routes (oral for food and mainly dermal for cosmetics), some challenges are very similar (e.g., stability, bioactive load, average size, increase of drug bioaccessibility and bioavailability). In the present work, a systematic review of the technological advancements in the nanoencapsulation of vitamins using liposomes and related processes was performed; challenges and future perspectives were also discussed in order to underline the advantages of these drug loaded biocompatible nanocarriers for cosmetics and food applications.
Soil Organic Carbon Stocks of Myanmar’s Shwe Thaung Yan Coastal Region and Accumulation in Magyi’s Mangroves Over Six Years
Authors: Aung Htay , Koirala Saroj , Htun Soe Thaw Thaw , Kontny Joacim , Naing Htun Thiri
Published: April 2023

We investigated and quantified soil organic carbon (SOC) stock at the mangrove forest (Magyi, That Bot Khan and Wette) of Shwe Thaung Yan coastal region in Myanmar and estimated the SOC stock changes in Magyi mangrove forest over six years using repeated field measurements. The study sites were characterized by different mangrove vegetation, soil types, and sediment deposition from different water sources. Results showed that the mangrove preservation and restoration efforts had a significant effect on soil C storage, with soil carbon stocks in 2021 (1954.43 ± 33.24 ton/ha) being 2.7 times higher than the estimated carbon stock in 2015 (732.26 ± 6.99 ton/ha). The results also revealed slight differences in SOC between Magyi and the Tha-Bot-Khan and Wette areas, as the mangrove plants in the latter areas have an additional source of nutrients from Pho-Thoung-Gyi, a deep-sea bay near the forest. Our research findings are beneficial in understanding the role of Myanmar’s mangrove ecosystems in carbon sequestration and climate change mitigation efforts.
Response of C:N:P in the plant-litter-soil system to phosphorus addition and stoichiometric homeostasis of plant tissues in a subtropical slash pine plantation
Authors: Jia Ting , Yi Min , Chen Fusheng , Lai Meng , Jin Cangfu , Nie Zixuan , Zhou Linjin , Xie Jinwen , Zhang Lu
Published: April 2023

Plants do need a fixed proportion of carbon (C), nitrogen (N) and phosphorus (P) elements to maintain normal metabolic activities. The P fertilizers are widely used to supplement nutrients in subtropical plantations. Stoichiometric homeostasis reflects the strategy of plants to cope with various environments (including P fertilizer supply rate). It is thus of great significance to understand C:N:P stoichiometry in the plant-litter-soil system under P addition and stoichiometric homeostasis of plant tissues for fertilization management of slash pine (Pinus elliottii Engelm) plantations. We measured the C, N and P contents in root, branch, needle, litter and soil in slash pine plantations fertilized with four treatments - P1 (25 kg P ha−1 yr−1), P2 (50 kg P ha−1 yr−1), P3 (100 kg P ha−1 yr−1), and a control (CK) in subtropical China and calculated stoichiometric homeostasis of plant tissues. Results showed that P addition increased the capacity of needle to obtain C, N and P elements and altered the C:N:P stoichiometry of plant tissues, as well promoted the accumulation of C and P elements in soil, but had no significant effect on soil stoichiometry. The nutrient contents of needle and branch were higher than those of root and litter, indicating that slash pine was more inclined to allocate nutrient to the aboveground tissues. The stoichiometric homeostasis of C, N and P among plant tissues was ranked as follows: root > branch > needle, and homeostasis of nutrient elements in the needle was C > N > P. This indicated that the C, N and P stoichiometric homeostasis was various among plant tissues and elements types under P addition. These findings suggest P addition would alleviate the P limitation of slash pine growth in subtropical regions. In the future, long-term observation experiments should be conducted and the trade-off between P addition rates and economic and ecological benefits should be considered.
The Limits of Artificial General Intelligence
Authors: Cárdenas-García Jaime F.
Published: April 2023

Recent developments, begun by the ascending spiral of the anticipated endless prospects of ChatGPT, promote artificial intelligence (AI) as an indispensable tool and commodity whose time has come. Yet the sinister specter of a technology that has hidden and unmanageable attributes that might be harmful to society looms in the background. As well as the likelihood that it will never deliver on the purported promise of artificial general intelligence (AGI). Currently the prospects for the development of AI and AGI are more a matter of opinion than based on a consistent methodological approach. Thus the need to take a step back to develop a general framework from which to evaluate current AI efforts, which also permits the determination of the limits to its future prospects as AGI. To gain insight into the development of a general framework, a key question that needs resolution is, what is the connection between human intelligence and machine intelligence? This is the question that needs a response because humans are at the center of AI creation and realize that without an understanding of how we become what we become, we have no chance of finding a solution. This work proposes infoautopoiesis, the self-referential, recursive and interactive process of self-production of information, as the needed general framework. Infoautopoiesis shows how the key ingredient of information is fundamental to an insightful resolution to this crucial question and allows predictions as to the present and future of AGI.
The Challenge of Emerging Resistant Gram-Positive Pathogens in Hip and Knee Periprosthetic Joint Infections
Authors: Garvin Kevin L. , Kildow Beau J. , Hewlett Angela L. , Hartman Curtis W. , Fey Paul D.
Published: April 2023

➤ An increase in resistant bacterial pathogens has occurred over the last 4 decades.

➤ Careful patient selection and improving or correcting risk factors for periprosthetic joint infection (PJI) before elective surgical treatment are strongly recommended.

➤ Appropriate microbiological methods, including those used to detect and grow Cutibacterium acnes, are recommended.

➤ Antimicrobial agents used in the prevention or management of infection should be selected appropriately and the duration of therapy should be carefully considered in order to mitigate the risk of developing bacterial resistance.

➤ Molecular methods including rapid polymerase chain reaction (PCR) diagnostics, 16S sequencing, and/or shotgun and/or targeted whole-genome sequencing are recommended in culture-negative cases of PJI.

➤ Expert consultation with an infectious diseases specialist (if available) is recommended to assist with the appropriate antimicrobial management and monitoring of patients with PJI.
From we ask to iASK: a self-reflection strategy that enables students to connect assessment and employability
Authors: Spagnoli Dino , Kinash Shelley , Jorre De St Jorre Trina , Male Sally , Mouat Clare M , McDougall Kevin
Published: April 2023

Most students acknowledge shared responsibility, with the university, for their employability development. Many academics use assessments as the main driver for motivating students to learn. At the intersection between employability, assessment and learning, the emergent research question is - what are the mechanisms by which course-based employability is fostered? Prior research reveals that although academics identified course-based assessment as the key employability mechanism, neither students nor employers registered this conceptualisation, and thus purpose of assessment. The aim of this research was to stimulate and communicate the direct connection between assessment and employability to students and interpret their response. Over 100 first-year students, across a metropolitan and regional Australian university, participated. Students were directed to use a simple reflective tool, dubbed iASK by the researchers, that probed employability elements of identity, Attributes, Skills, and Knowledge. The research revealed the resulting student view that regular course-based assessment can develop their employability skills in communication and independence, but not in critical thinking and global citizenship.
Improvement the expression and purification of Loa22: a lipoprotein with OmpA domain from pathogenic Leptospira serovars
Authors: Gharakhani Mehdi , Ghasemi Mohammad Faezi , Khaki Pejvak , Esmaelizad Majid , Tebianian Majid
Published: April 2023

Outer membrane proteins (OMPs) are the main surface antigens of the pathogenic Leptospires. One of the highly conserved outer membrane proteins expressed only by pathogenic Leptospires is Loa22. This study aims is to obtain the optimum conditions for high expression and purification of Loa22 recombinant (rLoa22) protein. Based on evidence of phylogenetic studies, complete coding sequence of loa22 gene was optimized based on codon usage chart and sub-cloned into a pET32a (+) expression vector. BL21 (pLysS) was used as expression host for transformation. The recombinant clones selected on ampicillin plates and subjected to PCR by using pET T7 primers and expression conditions optimized then by adjusting parameters such as culture media, induction time, temperature, and IPTG concentration. SDS-PAGE Analysis showed that the production of rLoa22 protein was at the highest level when post induction incubation, IPTG concentration, and duration of induction were 37ºC, 0.1 M and 5 h in 2xTY medium respectively. Due to the soluble nature of the protein, the purification of the rLoa22 protein under native conditions using Ni-NTA pull-down was optimum in one hour binding process at 37°C, five times washing process and elution buffer with a pH 7.4 and a 0.3 M imidazole concentration. Based on the results of this study, optimizing the expression and purification process for over production of rLoa22 protein resulted in the large quantity of pure recombinant antigen that forms the basis for future investigation on the design of rapid diagnostic tests and more effective subunit vaccine candidates for leptospirosis.
Physicochemical characterization of a lycopene-loaded mesoporous silica nanoparticle formulation
Authors: Carvalho Gabriela Corrêa , Marena Gabriel Davi , Nascimento André Luiz Carneiro Soares do , Camargo Bruna Almeida Furquim , Sábio Rafael Miguel , Lourenço Felipe Rebello , Santos Hélder A. , Chorilli Marlus
Published: April 2023

Lycopene (LYC), a carotenoid extracted mainly from tomatoes, has several biological properties, making its use desirable as a nutraceutical and pharmaceutical active ingredient. However, the use of LYC in therapy has limitations related to its solubility and stability. In this study, mesoporous silica nanoparticles (MSNs) are used to load and protect LYC from degradation. The exact amount of drug incorporated was determined by analytical techniques, such as high performance liquid chromatography (HPLC) and thermal analysis. For this we developed and validated an HPLC method for LYC quantification and evaluated the LYC impregnated in MSNs, followed by thermogravimetry analysis (TGA) technique analysis. Differential scanning calorimetry (DSC) was also used in order to confirm drug incorporation. Additionally, an in vitrorelease study was also carried out. The HPLC method was duly validated for the range of 26–125 µg/mL and proved to be suitable for LYC quantification. DSC measurements suggest an improvement in the stability of the impregnated drug, which was reinforced by the release assay. Overall, the developed method is suitable to test LYC-loaded porous materials to enable the use in therapeutic applications.
Flavopiridol suppresses cell proliferation and migration and induces apoptotic cell death by inhibiting oncogenic FOXM1 signaling in IDH-wild type and -mutant GBM cells
Authors: Güler Ahsen , Hamurcu Zuhal , Ulutabanca Halil , Cınar Venhar , Nurdinov Nursultan , Erdem Serife , Ozpolat Bulent
Published: April 2023

Glioblastoma multiforme (GBM) remains one of the most challenging solid cancers to treat due to its highly aggressive and drug resistant nature. Flavopiridol is synthetic flavone that was recently approved by the FDA for the treatment of acute myeloid leukemia. Flavopiridol exhibits antiproliferative activity in several solid cancer cells and currently evaluated in clinical trials in several solid and hematological cancers. In this study, we investigated the molecular mechanisms underlying antiproliferative effects of Flavopiridol in GBM cell lines with wild type and mutant IDH1 (encoding isocitrate dehydrogenase 1). We found that Flavopiridol inhibits proliferation, colony formation, migration, and induces apoptosis in IDH1-wild type and IDH-mutant cells through inhibition of FOXM1 oncogenic signaling. Furthermore, flavopiridol treatment also inhibits of NF-KB, mediators unfolded protein response (UPR) (GRP78, PERK, IRE1α) and DNA repair enzyme PARP, which have been shown, be potential therapeutic targets by downregulating FOXM1 in GBM cells.
Our findings suggest for the first time that flavopiridol suppresses proliferation, survival and migration and induces apoptosis in IDH1-wild type and mutant GBM cells by targeting FOXM1 oncogenic signaling which also regulates NF-KB, PARP, UPR responsein GBM cells. Flavopiridol may be a potential novel therapeutic strategy in the treatment of patients IDH1-wild type and mutant GBM.
Variability of toe pressures during haemodialysis: Comparison of people with and without diabetes; a pilot study
Authors: Carle Rachel , Tehan Peta , Stewart Sarah , Semple David , Pilmore Andrew , Carroll Matthew
Published: April 2023

Background Diabetes, end stage renal disease (ESRD), and peripheral arterial disease (PAD) are associated with a higher risk of diabetes-related lower limb amputation. Timely identification of PAD with toe systolic blood pressure (TSBP) and toe-brachial pressure index (TBPI) is critical in order to implement foot protection strategies to prevent foot complications in people with ESRD. There is limited evidence describing the effect of haemodialysis on TSBP and TBPI. This study aimed to determine the variability of TSBP and TBPI during haemodialysis in people with ESRD, and to determine whether any observed variability differed between people with and without diabetes.Methods TSBP and TBPI were taken before dialysis (T1), one hour into dialysis (T2) and in the last 15 minutes of dialysis (T3) during a single dialysis session. Linear mixed effects models were undertaken to determine the variability in TSBP and TBPI across the three time points and to determine whether this variability differed between people with and without diabetes.Results Thirty participants were recruited, including 17 (57%) with diabetes and 13 (43%) with no diabetes. A significant overall reduction in TSBP was observed across all participants (P < 0.001). There was a significant reduction in TSBP between T1 and T2 (P < 0.001) and between T1 and T3 (P < 0.001). There was no significant overall change in TBPI over time (P = 0.62). There was no significant overall difference in TSBP between people with diabetes and people with no diabetes (mean difference [95% CI]: -9.28 [-40.20, 21.64], P = 0.54). There was no significant overall difference in TBPI between people with diabetes and people with no diabetes (mean difference [95% CI]: -0.01 [-0.17, 03.16], P = 0.91).Conclusion TSBP and TBPI are an essential part of vascular assessment of the lower limb. TBPI remained stable and TSBP significantly reduced during dialysis. Given the frequency and duration of dialysis, clinicians taking toe pressures to screen for PAD should be aware of this reduction and consider how this may have an impact wound healing capacity and the development of foot related complications.
Zero To Hero? Reducing The Rate of Acute Kidney Injury in Transcatheter Aortic Valve Replacement: The Low Contrast Approach
Authors: Giraldo-Grueso Manuel , Bedi Ryan S. , Tafur-Soto Jose , Spindel Stephen M.
Published: April 2023

Background: Acute kidney injury is a complication after transcatheter aortic valve replacement (TAVR) that increases hospital stay, morbidity, and mortality; moreover, the amount of contrast has been linked to acute kidney injury. Reducing the contrast during TAVR is hypothesized to decrease acute kidney injury without compromising outcomes.
Methods: A single-institution retrospective analysis was performed on patients undergoing TAVR from 2017 to 2019. Patients with 20 mL or less of contrast were labeled as group I, and patients with more than 20mL of contrast were labeled as group II. Primary endpoints were 30-day mortality, acute kidney injury, and early aortic regurgitation.
Results: Between 2017 and 2019, 597 patients underwent TAVR, of which 594 met the inclusion and exclusion criteria. Four hundred twenty-nine (71%) patients were included in group I, and 165 (29%) were included in group II. Two hundred eight patients (51%) and 41 patients (24.6%) from group I and group II had chronic kidney disease stage III or IV. The mean contrast volume was 8.5mL (± 6) for group I and 33mL (± 16) for group II (p<0.001).Thirteen patients (3%) from group I had acute kidney injury; six (1.5%) required hemodialysis. In group II, nine (5.5%) patients had acute kidney injury (p=0.146); one required hemodialysis (p=0.435). Of all, 579 (97%) had less than moderate aortic regurgitation in the postoperative echocardiogram.
Conclusion: Low contrast TAVR is safe and effective and can reduce the incidence of acute kidney injury without affecting outcomes such as death, aortic regurgitation, and the need for a permanent pacemaker.
Profiling virulence genes in Palestinian strains of community- acquired methicillin-resistant Staphylococcus aureus, exposing those encoding exfoliative toxin
Authors: Azmi Kifaya , Qrei Walaa , Abdeen Ziad
Published: April 2023

The genes of Staphylococcus aureus encode several toxins causing or strongly suspected of causing specific diseases and adverse symptoms. The distribution of genes encoding superantigens and the gene profiles and genetic background of Palestinian strains of methicillin-resistant Staphylococcus aureus (MRSA) were determined. Strains separated into 12 clonal complexes (CCs) and 41 spa types, and possessed at least one of the studied enterotoxin genes: seo being most prevalent in 69.7% of the strains: followed by seh in 53.3% of the strains. Many (42.6%) of the strains possessed the genes for the classic staphylococcal enterotoxin (SE) sea, seb, sec, sed, and see, whereas 69.2% of the strains possessed the genes of the enterotoxin gene cluster, (egc), seg, seo, seh, sei, sem, seq, sej, sen, sek, sep, seu, sel, ser. Of the strains of S. aureus possessing the genes for Panton-Valentine leucocidin (PVL, n=105) among the strains of CA-MRSA, 16.2% (17/105) belonged to CC8-t008 and 18.1% (19/105) to CC80-t044. All four accessory gene regulator (agr) groups were present with agr group 1 being predominant in 44.1% of the strains. Forty-nine (25%) strains were multidrug resistant (MDR). This study provides information on the molecular markers of strains of S. aureus in clinical samples taken from Palestinian patients, including the characteristics of toxin genes possessed by Palestinian strains of CA-MRSA.
Evaluation of the influence of flame retardant additives on the creep behavior of ABS
Authors: Silva Thiago Moreira da , d’Almeida José Roberto Moraes , Cardoso Daniel Carlos Taissum
Published: April 2023

In this work, the effect of flame redardant additives on the creep behavior of ABS polymer was studied. Three ABS/flame redardant systems were compared with the bare ABS samples, namely: a commercial additive system based on bromine (Br-ABS), which served as a basis for comparison, and two systems recently developed, using tannic acid (TA) and ammonium polyphosphate (APP) bio-retardants. The results obtained in the creep tests showed that the commercial additive did not change the creep behavior in relation to ABS without additive. On the other hand, the results indicated that creep behavior was reduced when APP was incorporated into ABS and increased when TA was added. Experimental data from creep tests were used to evaluate the viscoelastic behavior of the four groups of materials. ABS had its behavior adequately represented by the Stretched Burgers model, as well as ABS with bromine-based additive, although with a low correlation coefficient. The model that best described the behavior of ABS with ammonium polyphosphate (APP) was also the modified Burgers model (Streched Burgers model). For ABS with tannic acid (TA), the model that best described the behavior was the standard linear solid.
Comprehensive and individualized surgical treatment strategy for distal tibia osteomyelitis: a retrospective study of 70 patients
Authors: Alimujiang Abudusalamu , Jia Qiyu , Guo Jian , Wu Tong , Zhang Jun , Wang Xi , Chen Guoqing , Ma Chuang
Published: April 2023

Background Distal tibia osteomyelitis (DTO) treatment has become a challenging problem due to its difficult treatment and special location. Our goal is to provide a comprehensive and individualized treatment strategy, and to investigate the associated complications.Methods We retrospectively analyzed the data of 70 patients with DTO diagnosed and treated in our hospital from January 2015 to January 2022. The average age was 42.5 years (12–73 years), there were 34 cases accompanied by bone defects, and the average length of the bone defect was 3.2 cm (2 cm–17 cm). We divided the patients into three groups based on infection severity and specific location: 25 cases of a simple type (S type), 23 cases of complex ankle non-involved type (CAN type), and 22 cases of complex ankle involved type (CAI type). Comprehensive individualized treatment, including debridement, reconstruction, arthrodesis, and other surgical methods, was performed on patients of various types, rehabilitation exercises were guided, and patients were closely monitored. The efficacy was assessed using the following criteria: (1) treatment and related complications; (2) infection and defect healing; (3) improvement of ADL, VAS, and AOFAS scores; (4) evaluation of patients undergoing Ilizarov distraction osteogenesis; and (5) evaluation of patients undergoing ankle arthrodesis.Results The follow-up time was 30 months (10–84 months). With the exception of three patients who required amputation due to aggravated infection and concomitant basic diseases, all patients achieved infection control and healing, and the complications were properly treated. Three scores of patients with different types were significantly improved, and the differences were statistically significant. Patients undergoing Ilizarov distraction osteogenesis had satisfactory results, and the superior rates of ASAMI bone evaluation and function evaluation were 89%. All patients with ankle arthrodesis finally achieved bone healing, and the average fusion time was 4.5 months (3–7 months).Conclusion The comprehensive individualized treatment strategy is reliable for the treatment of DTO, as it can guide individualized treatment under different conditions, solve the problem of bone and soft tissue defects while controlling infection, reduce complications and properly handle them, and save as much function of the affected limb as possible.
Application of Slam Method in Big Data Rural Tourism Management in Dynamic Scene
Authors: Hao Yingcheng , Zheng Lili
Published: April 2023

Under the background of the rapid development of science and technology, technologies in many fields are advancing accordingly. The same artificial intelligence and computer vision technologies are also constantly being updated. Similarly, in vision On the basis of, positioning and mapping (technology is the core technology for mobile robots to complete the intelligentization) has also had a great response in the academic and industrial circles, and has attracted the attention of most scholars. Today, the construction of smart tourism is in a prosperous stage. Based on the big data of rural tourism construction in a certain province, this article mainly uses the SLAM method that relies on visual characteristics under dynamic scenes to study the construction of rural tourism platform. In this paper, considering the influence of many factors, based on the ORB-SLAM2 system, a visual SLAM system is established. At the same time, the mathematical model of the SLAM system is established and used RGB-D The depth camera is used as the input sensor, the visual odometer locates the camera, the nonlinear optimization optimizes the data association, the closed-loop detection completes the camera repositioning, the map construction completes the environment description and other multi-module collaborations, which together complete the simultaneous positioning of the camera and the map Build work.
Design of financial management database for automobile enterprises based on image encryption algorithm
Authors: Gao Lin
Published: April 2023

The automobile industry has a history of more than 100 years in foreign countries, so it is the continuous progress of professional automobile enterprises that has promoted the continuous development of the automobile industry. Financial management and database system provide many automobile companies with the best financial management solutions in the industry. As the core of financial management, it is highly integrated with the fixed assets module, which makes the financial management in the information management system of automobile enterprises closely connected with the daily management of automobile enterprises. At present, the original data management of each unit in the financial management system of automobile enterprises is still not subject to regulatory control, and the financial responsibility and financial data are often inaccurate. The current financial system is not scientific in product pricing, and it is difficult to provide detailed and accurate cost analysis and difference analysis results. Finally, for automobile enterprises, a unified and integrated financial management database system should be used to better manage the financial and operating conditions of automobile companies. After outlining the general procedures of the encryption algorithm, this document introduces the security characteristics and sensitivity analysis of the image encryption algorithm key. The security of the image encryption algorithm is strengthened, and the encrypted image is checked separately. Based on this content, this paper analyzes the financial management system of automobile enterprises in general, and explains the process of fixed assets storage and special storage in the software. Then, by optimizing the overall structure design of financial management, the system design of financial management database is proposed. After understanding the shortcomings of current financial software in meeting user needs, the design objectives and tasks of financial management database are provided, and the system design of automobile financial management database is summarized, and the outlook after the system design is put forward.
Evaluation of tornadic environments and their trends and projected changes in Japan
Authors: Kawazoe Sho , Inatsu Masaru , Fujita Mikiko , Sugimoto Shiori , Okada Yasuko , Watanabe Shingo
Published: April 2023

Tornadoes are responsible for several high impact weather related disasters in Japan. However, little is known about how these events have changed over the last several decades or how they may change in future climates. This study examines environmental conditions associated with tornados in Japan using pseudo-soundings from the high-resolution fifth-generation ECMWF reanalysis. We first determine appropriate discriminators of F2 + tornadoes using thermodynamic (convective available potential energy, convective inhibition, lifting condensation level, and the K-index), kinematic (deep layer shear and storm-relative helicity), and multivariate tornado parameters (energy helicity index, K-helicity index, and the significant tornado parameter), and confirm that F2 + tornadoes occur in environments with higher instability and helicity, but are better distinguished using multivariate parameters. Recent trends indicate that in some of the most densely populated regions, F2 + environments have increased significantly over the last four decades. We also examined future changes for each parameter using a large ensemble 2-K warming experiment. Robust increases in strong tornado environments are depicted in many regions in Japan, particularly on the Sea of Japan side and the Kanto region. This indicates that despite projected decreases in deep layer shear and higher convective inhibition, significant increases in atmospheric instability compensate, leading to more days with F2 + tornado potential.
Evaluating skill in predicting the Interdecadal Pacific Oscillation in initialized decadal climate prediction hindcasts in E3SMv1 and CESM1 using two different initialization methods and a small set of start years
Authors: Meehl Gerald , Kirtman Ben , Glanville Anne A. , Richter Jadwiga , Rosenbloom Nan , Yeager Stephen
Published: April 2023

Having to run a large set of initialized hindcasts with many ensemble members for enough samples of start years to form a drifted climatology from which to compute anomalies to compare to observations (to quantify skill of the hindcasts) is a daunting computational challenge. This limits the ability to experiment with case studies and other applications where only a few initial years are needed. Here we run a set of hindcasts with CESM1 and E3SMv1 using two different initialization methods for a limited set of start years and use the respective uninitialized free-running historical simulations to form the model climatologies. Since the drifts from the observed initial states in the hindcasts toward the uninitialized model state are large and rapid, after a few years the drifted initialized models approach the uninitialized model climatological errors. Therefore, hindcasts from the limited start years can use the uninitialized climatology to represent the drifted model states after about lead year 3, providing a means to compute forecast anomalies in the absence of a large hindcast sample. There is comparable skill for predicting the Interdecadal Pacific Oscillation using this method compared to the conventional methodology with a large hindcast data set. The drifts are somewhat different in the two initialization methods, but the drifts are so large and consistent that by about lead year 3 the two methods are roughly comparable, though there is a model dependence to the drifts in the two initialization methods.
Gene Identification, Expression Analysis, and Molecular Docking of SAT/OASTL Reveal the Molecular Mechanisms of Selenocysteine Synthesis in Cardamine hupingshanensis
Authors: chen yushan , Luo Cihang , Liu Yi , Xiao Zhijing , Lu Yanke , Hou Zhi , Xiao Qiang , Zhou Yifeng , Tang Qiaoyu
Published: April 2023

Background A complex coupled with serine acetyltransferase (SAT) and O-acetyl serine (thiol) lyase (OASTL) is the key enzyme that catalyses selenocysteine synthesis in plants. The basic bioinformatics and functions of these two gene families have been reported for many plants in addition to Cardamine hupingshanensis, and the response of the ChSAT and ChOASTL family members under selenium stress has not been examined to date.Results In this study, genome-wide identification and comparative analysis of ChSAT and ChOASTL were performed. The eight genes from the ChSAT family were divided into three branches, and the thirteen genes from the ChOASTL family were divided into four branches by phylogenetic analysis and sequence alignment, indicating the evolutionary conservation of the gene structure and its association with other plant species. The expression of members in the ChSAT and ChOASTL families was studied under selenium stress, and ChSAT1;2 and ChOASTLA1;2 were upregulated by 9.4- and 7.4-fold, respectively, showing that these two proteins are involved in the synthesis of selenocysteine. Likewise, ChCS-like protein was upregulated by 8.8-fold, playing key roles in degradation. In addition, molecular docking simulations showed that ChOASTL binds to the test compound selenophosphate more strongly than selenide and sulfide, and the major motifs that bind the target compound are usually located at residues of amino acids Lys46, Gly181, Thr182, Gly183, Thr185 and Ser269.Conclusions This study revealed that selenophosphate was the optimal substrate of ChOASTL and participated in selenocysteine synthesis. The results of gene expression and molecular docking indicated that the ChSAT and ChOASTL genes were upregulated under selenium stress, and ChOASTL family genes could both synthesize and degrade cysteine/selenocysteine, which provided a theoretical basis for the regulation of selenocysteine synthesis.