bluuebunny/crossref_metadata_2025 huggingface dataset:
Duration of Cattle Ranching Affects Dung Beetle Diversity and Secondary Seed Removal in Tropical Dry Forest Landscapes
Authors: Morales-Trejo Juan J. , Dáttilo Wesley , Zurita Gustavo , Arellano Lucrecia
Published: September 2024

Cattle ranching is an economic activity responsible for the loss of large extensions of tropical dry forest around the world. Several studies have demonstrated that the use of inadequate practices of this activity in tropical forests (e.g., fire, agrochemicals, and lack of rotational grazing systems of cattle in pastures) have negative consequences on dung beetle diversity and their ecological functions. In the present study, the influence of the cattle ranching duration gradient on the diversity of dung beetles and seed removal was evaluated. This study was carried out in pastures with different times of establishment of cattle ranching (between 4 and 40 years) in a tropical dry forest of Mexico. Overall, the species richness of dung beetles was similar along the gradient of grazing ages. However, the diversity of common (q1) and dominant (q2) species decreased and was associated with an increasing abundance of exotic species and a decreasing abundance of native species. Seed removal was mainly carried out by four beetle species, among which the exotic species Digitonthophagus gazella was the most important. The results establish that the duration of cattle ranching primarily influences the composition of dung beetle communities, as reflected in changes in the structure and function of their assemblages in the pastures. Although native dung beetles persist at low abundances along this gradient, the consequences of land use changes are undeniable in other similar ecosystems where these species could definitively disappear.
Exploring the Impact of Inhaled Corticosteroids on Endothelial Function in Chronic Obstructive Pulmonary Disease Patients Undergoing Pulmonary Rehabilitation
Authors: Ambrosino Pasquale , Candia Claudio , Merola Claudia , Lombardi Carmen , Mancusi Costantino , Matera Maria Gabriella , Cazzola Mario , Maniscalco Mauro
Published: September 2024

Background: Chronic obstructive pulmonary disease (COPD) is associated with subclinical atherosclerosis and endothelial dysfunction, which can be assessed non-invasively through flow-mediated dilation (FMD). In this study, we evaluated the potential impact of inhaled corticosteroid (ICS) therapy on FMD of COPD patients undergoing pulmonary rehabilitation (PR). Methods: Medical records of COPD patients undergoing FMD assessment upon admission to our Pulmonary Rehabilitation Unit were reviewed in this retrospective post hoc analysis. Results: A total of 46 patients with COPD (median age 71.5 years, 28.3% postmenopausal females) were included in the final analysis. Among these, 27 participants were currently receiving ICS therapy, while 19 were not. At baseline, the two groups showed no difference in the main clinical and functional variables. Similarly, no significant difference was observed in vascular reactivity parameters, with a median FMD of 3.12% (IQR: 2.23–4.45) in ICS users and 3.39% (IQR: 2.45–4.08) in ICS nonusers (p = 0.544). After PR, a significant improvement in the main rehabilitation and patient-reported outcomes was observed in all groups, with a significant improvement in FMD documented in both patients treated with steroids (from 3.12%; IQR: 2.23–4.45 to 4.77%; IQR: 3.25–5.63, p = 0.022) and in those who were not (from 3.39%; IQR: 2.45–4.08 to 5.04%; IQR: 3.98–6.06, p = 0.005). FMD changes were of comparable magnitude among groups. Conclusions: Our preliminary findings do not indicate a significant impact of medications containing ICS on the endothelial function of COPD patients, suggesting that the potential beneficial effect of PR on this surrogate marker of cardiovascular risk is independent of inhaled therapy.
Detection Rate of Fetal Anomalies in Early Mid-Trimester Compared to Late Mid-Trimester Detailed Scans: Possible Implications for First-Trimester Sonography
Authors: Yehudit Zangi , Rachel Michaelson-Cohen , Ari Weiss , Ori Shen , Eyal Mazaki , Yitzhak Sela Hen
Published: September 2024

Objective: A late mid-trimester fetal organ scan (lMTS) is recommended between 18 and 22 weeks of pregnancy. Evidence has been accumulating on the effectiveness of first-trimester anatomy scans. Early mid-trimester fetal scans (eMTSs; 14–17 weeks) may have the advantage of visualization of most organs, hence allowing earlier genetic assessment and decision making. Our aim is to examine the effectiveness of eMTSs in identifying fetal anomalies compared to lMTSs. Methods: A retrospective study was conducted based on data from the multidisciplinary prenatal diagnosis clinic in a tertiary center. During the study period (2011–2021), an out-of-pocket eMTS in a community setting was offered routinely to the general population. Women who had previously undergone an eMTS and were later assessed due to a fetal anomaly in our clinic were included in the study. The cohort was divided into two groups according to whether the anomaly had been detected during the eMTS. We then compared the groups for factors that may be associated with anomaly detection in eMTSs. We used t-tests and chi-square tests, for quantitative and qualitative variables, respectively, to determine variables related to eMTS anomaly detection, and logistic regression for multivariate analysis. Results: Of 1525 women assessed in our multidisciplinary clinic, 340 were included in the study. The anomaly detection rate of the eMTS compared to the lMTS was 59.1% The eMTS detection rates for specific organ systems were as follows: skeletal, 57%; cardiac, 52%; congenital anomalies of the kidneys and urinary tract (CAKUT), 44%; central nervous system, 32.4%; chest, 33%; and abdominal, 28%. In multivariate analysis, abnormal first-trimester screening (aOR 3.2; 95%CI 1.26–8.08) and multiple anomalies (aOR 1.86; 95%CI 1.02–3.37) were found to be associated with eMTS anomaly detection. Conclusions: The eMTS detection rate was nearly 60% and was most accurate in detecting skeletal, cardiac, and CAKUT anomalies. Since the eMTS was community-based, this rate likely reflects a “real-world” scenario. Our findings support consideration of performing an eMTS or first-trimester scan routinely for earlier diagnosis and decision making, as an adjunctive to lMTSs. Future studies will examine the cost-effectiveness of early scans.
Avoiding Misdiagnosis in Global Rostral Midbrain Syndrome (GRMS): Clinical Insights and Neurorehabilitation Approaches
Authors: Jöhr Jane , Alioth Aurea , Catalano Chiuvé Sabina , Nazeeruddin Sameer , Belouaer Amani , Daniel Roy Thomas , Momjian Shahan , Diserens Karin , Bally Julien F.
Published: September 2024

This study reports two cases of Global Rostral Midbrain Syndrome (GRMS) and corpus callosum infarction in the context of shunt overdrainage caused by obstructive hydrocephalus due to aqueductal stenosis. We detail how thorough clinical evaluation and appropriate investigation helped avoid a coma misdiagnosis and describe the excellent response to pharmacological treatment and successful neurorehabilitation in both cases. We analyze the cognitive profile of patients with GRMS, a rare condition that mimics disorders such as coma and progressive supranuclear palsy at various stages. In conscious cases, GRMS typically presents with parkinsonian syndrome, Parinaud syndrome, and cognitive issues. The awareness of this rare complication of shunt overdrainage facilitates more accurate diagnosis and better management.
Frailty and Medication Appropriateness in Rural Adults: Proposing Interventions through Pharmacist–Physician Collaborative Efforts
Authors: García Cristina , Ocaña José M. , Alacreu Mónica , Moreno Lucrecia , Martínez Luis A.
Published: September 2024

Background: Frailty and polymedication are closely interrelated. Addressing these concurrent conditions in primary care settings relies on the utilization of potentially inappropriate medication (PIM) lists and medication reviews (MRs), particularly in rural areas, where healthcare professionals serve as the sole point of access to the medical system. The aim of this study was to examine the relationship between medication appropriateness and variables related to frailty in a rural municipality in order to propose potential strategies for therapy optimization. Methods: This cross-sectional study included all adult community dwellers aged 50 and above officially registered in the municipality of Tiriez (Albacete, Spain) in 2023 (n = 241). The primary outcome variable was frailty (assessed using the fatigue, resistance, ambulation, illness, and loss of weight (FRAIL) scale). The independent variables were age, gender, medication regimen, history of falls, comorbidities, PIMs (evaluated using the screening tool of older persons’ prescriptions (STOPP) 2023 criteria), fall-risk-increasing drugs (FRID), and anticholinergic burden (ACB). Results: The prevalence of frailty was approximately 20%. FRID and ACB scores were statistically associated (p-value < 0.001) with frailty, 1.1 ± 1.3 vs. 2.5 ± 1.7, and 1.0 ± 1.3 vs. 2.8 ± 2.5, respectively. Regardless of age, frailty was observed to be more prevalent among females (odds ratio (OR) [95% confidence interval (CI)]: 3.5 [1.5, 9.0]). On average, 2.1 ± 1.6 STOPP criteria were fulfilled, with the prolonged use of anxiolytics and anti-peptic-ulcer agents being the most frequent. Priority interventions (PIs) included opioid dose reduction, benzodiazepine withdrawal, and the assessment of antidepressant and antiplatelet treatment plans. Conclusions: The optimization of medication in primary care is of paramount importance for frail patients. Interventional measures should focus on ensuring the correct dosage and combination of drugs for each therapeutic regimen.
Transforming Heart Failure Management: The Power of Strain Imaging, 3D Imaging, and Vortex Analysis in Echocardiography
Authors: Galzerano Domenico , Savo Maria Teresa , Castaldi Biagio , Kholaif Naji , Khaliel Feras , Pozza Alice , Aljheish Saif , Cattapan Irene , Martini Marika , Lassandro Eleonora , Cordoni Gabriele , Tansella Donatella , Cozac Dan Alexandru , Alamro Bandar , Di Salvo Giovanni
Published: September 2024

Heart failure (HF) remains a critical global health challenge, necessitating advancements in diagnostic and therapeutic strategies. This review explores the evolution of imaging technologies and their impact on HF management, focusing on three-dimensional echocardiography (3DE), myocardial strain imaging, and vortex dynamics imaging. Three-dimensional echocardiography enhances traditional echocardiography by providing more accurate assessments of cardiac structures, while myocardial strain imaging offers the early detection of subclinical myocardial dysfunction, crucial in conditions such as chemotherapy-induced cardiotoxicity and ischemic heart disease. Vortex dynamics imaging, a novel technique, provides insights into intracardiac flow patterns, aiding in the evaluation of left ventricular function, valve diseases, and congenital heart anomalies. The integration of these advanced imaging modalities into clinical practice facilitates personalized treatment strategies, enabling the earlier diagnosis and more precise monitoring of disease progression. The ongoing refinement of these imaging techniques holds promise for improving patient outcomes and advancing the field of precision medicine in HF care.
The Challenges of Treating a Helicobacter pylori Infection following the COVID-19 Pandemic in Croatia: A Review
Authors: Jukic Ivana , Vukovic Jonatan
Published: September 2024

Background: Helicobacter pylori (H. pylori) is a prevalent bacterial pathogen implicated in different stomach and duodenal diseases, including chronic gastritis, gastric and duodenal ulcer, and stomach cancer. The COVID-19 pandemic has significantly influenced antibiotic prescription practices, potentially exacerbating antibiotic resistance in H. pylori. Objective: This study aims to investigate antibiotic prescription during the COVID-19 pandemic in Croatia and its possible impact on H. pylori antibiotic resistance, with a focus on Croatia. Methods: An extensive literature search was conducted to identify relevant studies from March 2020 to June 2024. The search strategy included terms related to COVID-19, antibiotic prescription, and Croatia. Studies were selected based on predefined eligibility criteria, focusing on observational research addressing antibiotic use during the pandemic. Results: The COVID-19 pandemic has led to significant fluctuations in community antibiotic consumption within the European Union/European Economic Area. In Croatia, antibiotic use in 2022 surpassed 2019 levels, driven by increased consumption of macrolides and other antibiotics. This surge, influenced by early pandemic treatment claims and penicillin shortages, contributed to rising antibiotic resistance in H. pylori. Resistance rates to clarithromycin and levofloxacin were notably high, driven by mutations in the 23S rRNA, gyrA, and gyrB genes. Discussion: The increased antibiotic use during the COVID-19 pandemic has highly likely complicated H. pylori eradication efforts, highlighting the necessity of judicious antibiotic use and robust antimicrobial stewardship. The pandemic underscored the need for new therapeutic strategies, optimized eradication regimens, and advanced diagnostic methods to manage bacterial infections effectively. Conclusions: The COVID-19 pandemic has significantly affected antibiotic use and resistance patterns, posing new challenges for H. pylori eradication. Addressing these challenges requires a multifaceted approach, including the development of new drugs and advanced diagnostics, coupled with sustained efforts in antimicrobial stewardship to combat emerging resistance threats.
Utilization of Partial Cytoreductive Nephrectomy in Patients with Metastatic Renal Cell Carcinoma
Authors: Hauser Nicholas , Giakas Julian , Robinson Hunter , Davaro Facundo , Hamilton Zachary
Published: September 2024

Objectives: Cytoreductive nephrectomy for metastatic renal cell carcinoma (mRCC) is a standard of care. Partial nephrectomy (PN) in the setting of metastatic disease is an uncommon occurrence, and we aimed to characterize its utilization in a modern cohort. Methods: The National Cancer Database was reviewed for patients with mRCC from 2010 to 2017. Patients with cTanyNanyM1 who underwent cytoreductive surgery in the form of PN or radical nephrectomy (RN) were compiled. Our primary outcome was survival outcome for patients who underwent PN compared to RN. Secondary outcomes included 30-day readmission, length of stay, and survival outcomes. Results obtained: A total of 13,896 patients with mRCC who underwent cytoreductive surgery were identified. In total, 13,242 underwent RN and 654 underwent PN. The RN population was more likely to have cN positive disease, while the PN population was more likely to have cT1 disease. Length of stay, readmission and 30-day mortality were not significantly different between PN and RN, but overall mortality and 90-day mortality favored PN (p < 0.001). Cox regression for death showed PN with improved overall survival (HR 0.782, p < 0.001). Logistic regression for predictors of cytoreductive PN revealed cT1 and cN0 as significant factors. Overall survival, as seen on KM analysis, identified that PN exhibited improved 2-year (67.1% vs. 52.0%) and 5-year (40.7% vs. 29.2%) overall survival relative to RN (p < 0.001). Conclusions: PN is an infrequent treatment with mRCC and its utilization is stable from 2010 to 2017. Overall survival is significantly better for those undergoing PN, likely due to their favorable oncologic disease characteristics.
Damage Characteristics of Structure under Underwater Explosion and Bubble Flooding Loads
Authors: Li Qin , Luo Xiao , Zhong Zi-Xian , Zhang Guo-Hui , Wang Zhong , Hu Hai-Bao , Huang Xiao
Published: September 2024

Numerous studies have shown that explosive sequence loads can cause serious damage to underwater vehicles, especially the bubble surge in the later stage of the explosion, which poses a huge threat to the internal structure of the vehicle. This study explores the damage characteristics of cylindrical shell structures under complete sequence loads based on the Arbitrary Lagrangian–Eulerian (ALE) method. By conducting experiments on the surge characteristics near the damaged plate under explosive action and comparing them with numerical results, the effectiveness of the method is verified. Subsequently, the damage characteristics of single- and double-layered cylindrical shell structures under underwater explosion sequence loads (shock waves, bubbles, surges) were explored, and the failure modes of cylindrical shell structures under various loads were summarized. The results indicate that the damage of shock waves to single-layer cylindrical shell structures is most severe at a blast distance of 0.5 m. For double-layer cylindrical shells, increasing the blast distance will reduce the impact of bubble surge on the pressure-resistant shell. The stress and strain in the central area of the pressure-resistant shell also decrease, and the deflection and Z-direction velocity also decrease accordingly. This study laid the foundation for enhancing the impact resistance of underwater vehicles.
A Physic-Informed Data-Driven Relational Model of Plastic Strain vs. Process Parameters during Integrated Heating and Mechanical Rolling Forming of Hull Plates
Authors: Wei Zhenshuai , Zhao Yao , Yuan Hua , Chang Lichun
Published: September 2024

Integrated heat and roll forming (IHMRF) is a process that uses thermal and mechanical loads to produce localized plastic strains in plates to form complex curvature hull plates. The magnitude of the resulting plastic strain depends mainly on the following forming parameters: the machining parameters (power of the heat source, speed of the heat source, and the forming depth of the rollers), the thickness of the plate, and the thermo-physical and mechanical properties of the plate. Finding the correspondence between the plastic strain and forming parameters is the key to selecting the appropriate machining parameters for forming. A data-driven approach is ideal for this purpose. However, due to the characteristics of the IHMRF process, the forming process involves a large number of variables, and different materials have different temperature-dependent yield strengths. These high-dimensional input characteristics create a conflict between the required number of samples and the model training requirements. This paper presents a physically informed data-driven (PIDD) approach for modeling the relationship between forming parameters and plastic strains in IHMRF. Based on dimensional analysis and domain knowledge, the proposed method derives the basic thermal and mechanical relationships between the forming parameters, obtaining a much smaller number of physical parameters. These physical parameters are expressions of the physical knowledge of forming in low-dimensional space. Using the physical parameters yields higher accuracy on fewer sample data points than directly using the forming parameters as input features. Furthermore, the models trained on a variety of commonly used materials and plate thicknesses achieved comparable accuracy to the numerical simulation with unseen materials and plate thicknesses. Experimental and numerical simulations further verify the effectiveness of the proposed method by machining plates of various materials to the same shape.
Embracing Immersive Journalism: Adoption and Integration by News Media Producers
Authors: Eskiadi Ioanna Georgia , Panagiotou Nikolaos
Published: September 2024

Immersive journalism, utilizing virtual reality (VR) and augmented reality (AR) technologies, offers a transformative approach to storytelling by creating deeply engaging news experiences. This study examines the acceptance of immersive journalism by people working in news media industries focusing on different demographic groups. Using qualitative focus groups, participants from varied age groups experienced VR news stories and discussed their perceptions and responses. Key findings revealed high emotional engagement across all demographics, with younger participants showing greater enthusiasm and ease with the technology, while older participants expressed interest but faced technological barriers. Trust in the media and perceived realism were crucial factors influencing acceptance. Concerns about accessibility and inclusivity were also significant, particularly among older and less technologically proficient participants. This study concludes that, for immersive journalism to gain widespread acceptance, media organizations must address technological barriers, enhance user education, and ensure ethical standards in storytelling. These insights contribute to understanding how immersive journalism can be integrated into mainstream media to enhance audience engagement and trust, highlighting the importance of accessibility and emotional resonance in the adoption of innovative media technologies.
Patients’ Satisfaction after the Treatment of Moderate Sleep Apnea and Nocturnal Bruxism with Botox or/and Thermoformed Occlusal Splints: A Pilot Study
Authors: Rezk Gavrilă Taalat Gabriel , Bechir Anamaria , Nicolau Andrada Camelia , Bechir Edwin Sever
Published: September 2024

Background: Sleep apnea and nocturnal bruxism belong to sleep disorders that can affect the quality of life. The aim of this study was to investigate the effects on patients with moderate sleep apnea and nocturnal bruxism of Botox injection as monotherapy or associated with wearing thermoformed occlusal splints and to determine the patients’ satisfaction degree after the applied treatments. Methods: The selected patients for study were divided into two groups: in the first group, the patients (n = 18) treatment consisted of injecting Botox (Allergan) into the masseter muscle as monotherapy; in the second group, the patients (n = 18) benefited from associated therapy, Botox injections in masseter muscle, and the wear of thermoformed occlusal splints. At baseline, at three weeks, at three months, and six months after the effectuation of therapies, the monitoring sessions were realized. Results: The associated therapy presented better results in decreasing the studied symptoms than the monotherapy. Both therapies improved patient satisfaction. Conclusions: The applied therapies for treating the specific symptomatology in moderate sleep apnea and sleep bruxism were efficacious. Patient satisfaction was very good in both groups after the applied treatments, but the associated therapy presented better results than monotherapy.
The Role of Stereotactic Body Radiotherapy (SBRT) in Oligoprogressive Renal Cell Carcinoma (RCC) Treated with ICIs–TKIs: A Retrospective Multicentric Study
Authors: La Vecchia Maria , Federico Manuela , Aiello Dario , Zagardo Valentina , Mazzonello Antonella , Testa Lorella , La Paglia Leonarda , Bruno Tiziana , Fazio Ivan
Published: September 2024

Background: This multicentric, retrospective study investigated the use of stereotactic body radiotherapy (SBRT) in patients (pts) with metastatic renal cell carcinoma (mRCC) who experienced oligoprogression during a combination therapy with an immune checkpoint inhibitor (ICI) and a tyrosine–kinase inhibitor (TKI). Methods: We retrospectively evaluated 34 pts affected by oligoprogressive RCC treated with an ICI–TKI combination between January 2020 and December 2023. SBRT was delivered to each site of oligoprogressive metastatic disease. After SBRT, pts were given follow-up clinical evaluations. 6–12–18-month local control (LC) rates and median next-line treatment-free survival (NEST-FS) were the primary endpoints. The secondary endpoints were overall response rate (ORR), clinical benefits and safety. Results: After a median follow-up of 24 months, 6–12–18-month LC rates were 100%, 71% and 43%, respectively, and the median NEST-FS was 20 months. ORR was 90%, while clinical benefit was 100%. No > G2 adverse events related to SBRT were recorded. Conclusions: In our study, SBRT for oligoprogressive mRCC turned out to be a safe and useful treatment which was able to preserve current treatment. Further prospective studies are necessary to explore the effects of the ICIs–TKIs combination and SBRT upon oligoprogressive sites in mRCC.
Normalising the Implementation of Pharmacogenomic (PGx) Testing in Adult Mental Health Settings: A Theory-Based Systematic Review
Authors: Jameson Adam , Tomlinson Justine , Medlinskiene Kristina , Howard Dane , Saeed Imran , Sohal Jaspreet , Dalton Caroline , Sagoo Gurdeep S. , Cardno Alastair , Bristow Greg C. , Fylan Beth , McLean Samantha L.
Published: September 2024

Pharmacogenomic (PGx) testing can help personalise psychiatric prescribing and improve on the currently adopted trial-and-error prescribing approach. However, widespread implementation is yet to occur. Understanding factors influencing implementation is pertinent to the psychiatric PGx field. Normalisation Process Theory (NPT) seeks to understand the work involved during intervention implementation and is used by this review (PROSPERO: CRD42023399926) to explore factors influencing PGx implementation in psychiatry. Four databases were systematically searched for relevant records and assessed for eligibility following PRISMA guidance. The QuADS tool was applied during quality assessment of included records. Using an abductive approach to codebook thematic analysis, barrier and facilitator themes were developed using NPT as a theoretical framework. Twenty-nine records were included in the data synthesis. Key barrier themes included a PGx knowledge gap, a lack of consensus in policy and guidance, and uncertainty towards the use of PGx. Facilitator themes included an interest in PGx use as a new and improved approach to prescribing, a desire for a multidisciplinary approach to PGx implementation, and the importance of fostering a climate for PGx implementation. Using NPT, this novel review systematically summarises the literature in the psychiatric PGx implementation field. The findings highlight a need to develop national policies on using PGx, and an education and training workforce plan for mental health professionals. By understanding factors influencing implementation, the findings help to address the psychiatric PGx implementation gap. This helps move clinical practice closer towards a personalised psychotropic prescribing approach and associated improvements in patient outcomes. Future policy and research should focus on the appraisal of PGx implementation in psychiatry and the role of pharmacists in PGx service design, implementation, and delivery.
Prognostic Significance of CD11b-, CD8-, and CD163-Positive Tumor-Infiltrating Immune Cells in Distal Bile Duct Cancer
Authors: Choi Jae Hyung , Kim Joo Young , Lee Ki Rim , Lee Gyeong Yun , Hong Mineui , Hwang Hye Won , Lee Moo Yeol , Kim Mi Kyung , Hong Soon Auck
Published: September 2024

Background: Distal bile duct cancer is an aggressive malignancy. Tumor-infiltrating immune cells (TIICs) in the tumor microenvironment are crucial for predicting prognosis in various cancers. In this study, we analyzed TIICs based on CD11b, CD163, and CD8 expression, and evaluated their association with clinicopathologic factors and prognosis in distal bile duct cancer. Methods: A total of 90 patients who underwent curative resection for distal bile duct cancer were enrolled. We analyzed CD11b+ tumor-infiltrating myeloid cells (TIMs), CD163+ tumor-infiltrating macrophages (TAMs), and CD8+ tumor-infiltrating lymphocytes (TILs) using immunohistochemistry and tissue microarrays. The correlation between TIICs and clinicopathologic characteristics was assessed. Results: Low levels of CD11b+ TIMs (p < 0.001) and high levels of CD8+ TILs (p = 0.003) were significantly associated with improved overall survival (OS). A combined low level of CD11b+ TIMs and high level of CD8+ TILs was identified as an independent favorable prognostic factor (hazard ratio, 0.159; confidence interval, 0.061–0.410; p < 0.001). Conclusions: CD11b+ TIMs play a crucial role in the tumor microenvironment and the prognosis of distal bile duct cancer. The combined analysis of CD11b+ TIMs and CD8+ TILs can predict survival in patients with distal bile duct cancer.
The Impact of Land Use and Land Cover Changes on Ecosystem Services Value in Laos between 2000 and 2020
Authors: Ma Jun , Wang Jinliang , Zhang Jianpeng , He Suling , Liu Lanfang , Zhong Xuzheng
Published: September 2024

Land use and land cover changes significantly affect the function and value of ecosystem services (ES). Exploring the spatial correspondence between changes in land cover and ES is conducive to optimizing the land use structure and increasing regional coordinated development. Thus, this study aimed to examine changes in land use and land cover (30 × 30 m) in Laos between 2000 and 2020 and their effects on ecosystem services value (ESV) using the Global Surface Cover Database land use data for 2000 to 2020, ArcGIS technology, and the table of Costanza’s value coefficients. The study results indicated that forest (79.5%), cultivated land (10.6%), and grassland (8.3%) were the dominant land use types in Laos over the past two decades. The forest area decreased significantly, while there were increases in other land types, and the forest was transformed into cultivated land and grassland. ES in Laos was valued at about USD 140–150 billion, with forest contributing the most, followed by cultivated land and grassland. ESV over the last two decades in Laos has increased by USD 3.94 million. Large values were assigned to regulating services (40%) and supporting services (14%). The ESV of food production, soil formation, and water supply increased, and the ESV of climate regulation, genetic resources, and erosion control decreased. In addition, the elasticity value of artificial surfaces was more prominent, with a more evident impact on ESV. For future development, Laos should rationally plan land resources, develop sustainable industries, maintain the dynamic balance of second-category ESV, and achieve sustainable economic and ecological development. This study provides a scientific basis for revealing changes in ESV in Laos over the past two decades, maintaining the stability and sustainable development of the environment in Laos, and realizing the sustainable use and efficient management of the local environmental resources.
Wood Energy and Rural Planning: An Analysis of Land Use Policies in the Siting and Regulation of Forest-Based Bioenergy Technologies
Authors: Mittlefehldt Sarah , Bunting Erin , Welsh Joseph , Silver Emily , Curth Mya , McClure Mari , Neumann Bradley
Published: September 2024

Land use regulations have played a critical role in the siting and operation of renewable energy technologies. While there is a growing literature on the siting of wind and solar technologies, less is known about the relationship between local codes and planning decisions and the development of wood-based bioenergy technologies, particularly in rural places. This research examines the relationship between local land use policies and the siting and operation of different types of wood-based bioenergy technologies in northern Michigan, USA. Land use codes including zoning laws and ordinances related to wood-burning devices from 506 cities, townships, and villages within 36 counties in northern Michigan were combined with US Census data in a GIS database. ArcGIS was used to examine geographical differences between communities and socioeconomic factors related to different regulatory approaches. We found that areas with greater population densities and higher income and education levels tended to have more nuanced land use codes related to all scales of wood-burning, including residential wood heating, commercial-scale heating, and power generation. This paper emphasizes the importance of local decision-making and land use policies in shaping the development of wood-based energy technologies, and suggests the need for greater attention to rural community dynamics in planning the shift to a lower-carbon economy.
Unraveling Projected Changes in Spatiotemporal Patterns and Drought Events across Mainland China Using CMIP6 Models and an Intensity–Area–Duration Algorithm
Authors: Liu Jinping , Wu Junchao , Ali Sk Ajim , Linh Nguyen Thi Thuy , Ren Yanqun , Shalamzari Masoud Jafari
Published: September 2024

In the context of global warming, temperature increases have led to frequent drought events and a sharp increase in economic losses and social risks. In this study, five medium- and high-emission scenario models, the SSP245 and SSP585, CMIP6 monthly scale temperature and precipitation datasets under different global warming contexts (1.5 °C and 2 °C), and the 1984–2014 weather station observations were selected. The latter dataset was used to improve the ability of the CMIP6 to simulate surface drought accuracy. A standardized precipitation–evapotranspiration index dataset was generated. The latest intensity–area–duration framework was adopted to identify regional drought events by considering their continuity and spatial dynamic characteristics. The parameters of intensity, area, and duration were used to characterize the dynamic evolution of drought events. Under the medium- to high-emission scenario model, with a continuous increase in global temperature to 1.5 °C, in the southeastern Qinghai–Tibet Plateau (QTP) and southern Xinjiang (XJ) there is a significant increase in intensity, extent, and duration of drought events and some drought exacerbation in northeastern China. Under the high-emission SSP585 scenario model, the severity of these drought events is reduced when compared with the SSP245 scenario model, but this also shows an increasing trend, especially with the 2 °C global warming background. Significant drought aggravation trends were observed in southern XJ, northern QTP, and northern Northwest. In contrast, a small but significant drought-weakening trend was observed in southwestern south China. The results of this study provide a reference for society and government departments to make decisions in response to future drought events.
Association between Land Use and Urban Vitality in the Guangdong–Hong Kong–Macao Greater Bay Area: A Multiscale Study
Authors: Deng Cefang , Zhou Dailin , Wang Yiming , Wu Jie , Yin Zhe
Published: September 2024

Urban vitality, which indicates the development level of a city and the quality of life of its residents, is a complex subject in urban research due to its diverse assessment methods and intricate impact mechanisms. This study uses multisource data to evaluate the urban vitality of the Guangdong–Hong Kong–Macao Greater Bay Area (GBA) across social, economic, cultural, and environmental dimensions. It analyzes the spatial distribution characteristics of urban vitality and examines the relationships between urban vitality and land use at both regional and city scales. The results indicate that the urban vitality in the GBA generally exhibits a spatial distribution pattern of a high central density and a low peripheral spread, where built-up areas and cropland emerge as key influencing factors. Cities with different developmental backgrounds have unique relationships between land use and urban vitality. In high-vitality cities, the role of the built-up area diminishes, and natural ecosystems, such as wetlands, enhance vitality. In contrast, in low-vitality cities, built-up areas boost urban vitality, and agriculture-related land types exert a lower negative or even positive effect. This research contributes to the understanding of the spatial structures of urban vitality related to land use at different scales and offers insights for urban planners, builders, and development managers in formulating targeted urban vitality enhancement strategies at the regional collaborative and city levels.
Shift in Igbo Personal Naming Patterns
Authors: Ukaegbu Eunice Kingsley , Okon Bassey Andian
Published: September 2024

Some African societies use personal names as a means of conveying their cultural values, traditions, and experiences. Personal names are therefore an important means of identifying their bearers. However, in recent times, it has been observed that the practice of identity construction does not seem to apply in the naming patterns of some African societies. Among the Igbo people of southeastern Nigeria, there has been a shift in the contemporary naming of children as a result of greater media access, global communication, creativity, and the rising profile of Pentecostal Christianity. This study investigates the new trends in naming among the Igbo, as well as the motivations, semantic implications, and the general perception of these names by the Igbo people. Using the causal theory of names, this study adopts a qualitative design approach, and data were elicited from 100 participants who were mainly name-givers, bearers, and users. This study reveals a decline in the observance of the traditional naming patterns or practices of the Igbo, as it was noted that the new naming trend is related to favorableness toward Western culture, religion, and influence, which is seen as a form of style that connects name-bearers with prestige and modernity.
The Microbiota–Gut–Brain Axis and Neurological Disorders: A Comprehensive Review
Authors: Nakhal Mohammed M. , Yassin Lidya K. , Alyaqoubi Rana , Saeed Sara , Alderei Alreem , Alhammadi Alya , Alshehhi Mirah , Almehairbi Afra , Al Houqani Shaikha , BaniYas Shamsa , Qanadilo Haia , Ali Bassam R. , Shehab Safa , Statsenko Yauhen , Meribout Sarah , Sadek Bassem , Akour Amal , Hamad Mohammad I. K.
Published: September 2024

Microbes have inhabited the earth for hundreds of millions of years longer than humans. The microbiota–gut–brain axis (MGBA) represents a bidirectional communication pathway. These communications occur between the central nervous system (CNS), the enteric nervous system (ENS), and the emotional and cognitive centres of the brain. The field of research on the gut–brain axis has grown significantly during the past two decades. Signalling occurs between the gut microbiota and the brain through the neural, endocrine, immune, and humoral pathways. A substantial body of evidence indicates that the MGBA plays a pivotal role in various neurological diseases. These include Alzheimer’s disease (AD), autism spectrum disorder (ASD), Rett syndrome, attention deficit hyperactivity disorder (ADHD), non-Alzheimer’s neurodegeneration and dementias, fronto-temporal lobe dementia (FTLD), Wilson–Konovalov disease (WD), multisystem atrophy (MSA), Huntington’s chorea (HC), Parkinson’s disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), temporal lobe epilepsy (TLE), depression, and schizophrenia (SCZ). Furthermore, the bidirectional correlation between therapeutics and the gut–brain axis will be discussed. Conversely, the mood of delivery, exercise, psychotropic agents, stress, and neurologic drugs can influence the MGBA. By understanding the MGBA, it may be possible to facilitate research into microbial-based interventions and therapeutic strategies for neurological diseases.
Mechanism, Diagnostic and Therapeutic Novelties in Dermatology: Where Are We Going?
Authors: Ruiz-Villaverde Ricardo , Cebolla-Verdugo Marta , Prados-Carmona Alvaro , Pereyra Rodríguez José Juan , Armario-Hita José Carlos
Published: September 2024

Dermatology is one of the oldest specialties and yet one of the most innovative and constantly evolving ones, too [...]
Effect of Graphene on the Mechanical Properties of Recycled High-Density and High-Molecular-Weight Polyethylene Blends
Authors: Kharmoudi Hniya , Lamtai Alae , Elkoun Said , Robert Mathieu , Diez Carl
Published: September 2024

This study uses an extrusion process to formulate blends based on recycled high-density and high-molecular-weight polyethylene (recHDPE, recHMWPE) for the manufacture of rainwater drainage pipes. The main objective of this project is to investigate the effects of incorporating graphene on the mechanical, thermal, and stress-cracking resistance properties of the recycled HDPE and HMWPE blends. Also, it aims to demonstrate that the addition of graphene may enable the use of different recycled polymers without compromising their properties. The effects of adding two amounts of graphene (0.5 and 1%) to recycled blends on the tensile and flexion properties, stress crack resistance (SCR) (using a notched crack ligament stress (NCLS) test), thermal behavior (using a differential scanning calorimeter (DSC) and a rheological plastometer) were investigated. The experimental results showed a significative enhancement when adding graphene in the SCR, some tensile properties (elongation at break and tensile strength), and flexural modulus. However, physical characterization showed that the samples containing 0.5% graphene exhibited lower crystallinity compared to the reference and, for the blend with 1% graphene, the fluidity also decreased for the blend filled with the graphene compared to the reference blend without any filler.
Analysis of Copper Welding Parameters during the Manufacture of Tubular Profiles Using Unconventional Extrusion Processes
Authors: Knapiński Marcin , Bajor Teresa , Kawałek Anna , Banaszek Grzegorz
Published: September 2024

In recent years, there has been a lack of information in the literature regarding the extrusion and connection of closed profiles from oxygen-free copper in bridge dies. Available studies contain information on the processes of extrusion and connection of profiles from aluminium alloys and various types of steel. However, there is a lack of detailed data on the values of technological parameters for which copper is joined in the extrusion process. Therefore, one of the goals of this work is to fill the gap in the literature regarding the extrusion of oxygen-free copper in bridge dies. In this work, the authors determined the thermo-mechanical conditions at which oxygen-free copper will be joined. This paper describes the effects of charge temperature and hydrostatic pressure in the weld zone of a bridge die on copper bonding in the fabrication of tubular profiles. Physical tests of the welding process under the conditions of upsetting a material consisting of two parts were carried out using the Gleeble 3800 metallurgical process simulator with the PocketJaw module in the standard configuration for SICO (strain-induced crack opening) tests. For the numerical simulations, the commercial computer programme FORGE®NxT 2.1. using the finite element method (FEM) was used. Based on the analysis of the test results obtained, it was found that complete material bonding during the extrusion process could be achieved for a charge temperature higher than 600 °C and a hydrostatic pressure of 45–65 MPa.
Effect of N2/Ar Ratio on Wear Behavior of Multi-Element Nitride Coatings on AISI H13 Tool Steel
Authors: Hsu Cheng-Hsun , Chen Hong-Wei , Lin Chun-Yin , Hu Syue-Hong
Published: September 2024

In this study, multi-element nitride coatings composed of (Ti, Cr, Cu, Al, Si)N were synthesized on H13 tool steel using cathodic arc deposition (CAD) technology. The N2/Ar flow ratio varied from 0 to 2 as the experimental parameter, and two targets, Ti-Cr-Cu and Al-Si alloys, were utilized simultaneously. The impact of the gas flow ratio on the coatings’ abrasion properties was investigated, focusing on aspects, such as chemical composition, adhesion, hardness, and wear behavior. The experimental findings indicate that the coated specimens with a nitrogen reaction exhibit superior hardness and abrasion resistance compared to those without nitrogen use. While the surface roughness of the specimens tends to increase slightly with a higher N2/Ar ratio, the coating demonstrates improved hardness, adhesion, and abrasion resistance performance. In summary, the wear-resistant characteristics of H13 tool steel can be significantly enhanced when applying a CAD-(Ti, Cr, Cu, Al, Si)N film with a flow ratio of N2/Ar = 2.
Radiation Resistance of High-Entropy Alloys CoCrFeNi and CoCrFeMnNi, Sequentially Irradiated with Kr and He Ions
Authors: Amanzhulov Bauyrzhan , Ivanov Igor , Uglov Vladimir , Zlotski Sergey , Ryskulov Azamat , Kurakhmedov Alisher , Sapar Asset , Ungarbayev Yerulan , Koloberdin Mikhail , Zdorovets Maxim
Published: September 2024

This work studied the effect of sequential irradiation by krypton and helium ions at room temperature on the composition and structure of CoCrFeNi and CoCrFeMnNi high-entropy alloys (HEAs). Irradiation of the HEAs by 280 keV Kr14+ ions up to a fluence of 5 × 1015 cm–2 and 40 keV He2+ ions up to a fluence of 2 × 1017 cm–2 did not alter their elemental distribution and constituent phases. Blisters formed on the nickel surface after sequential irradiation, where large blisters had an average diameter of 3.8 μm. The lattice parameter of the (Co, Cr, Fe and Ni) and (Co, Cr, Fe, Mn and Ni) solid solutions increased by 0.17% and 0.37% after sequential irradiation, respectively. Irradiation by Kr ions led to a decrease in tensile macrostresses in the HEAs in the region of krypton ion implantation (Region I) and the formation of compressive macrostresses in the region behind the peak of implanted krypton (Region II). Sequential irradiation formed large compressive stresses in Ni and HEAs equal to −131.5 MPa, −300 MPa and −613.5 MPa in Ni, CoCrFeNi and CoCrFeMnNi, respectively, in the Region II. Irradiation by krypton ions decreased the dislocation density by 1.6–2.3 times, and irradiation with helium ions increased it by 11–15 times relative to unirradiated samples for CoCrFeNi and CoCrFeMnNi, respectively. Sequentially irradiated CoCrFeMnNi HEA had higher macrostresses and dislocation density than CoCrFeNi.
New Polymer Biocomposites Based on Biopoly(Ethylene Terephthalate) and Waste Mollusc Shells
Authors: Kuciel Stanisław , Rusin-Żurek Karina , Kurańska Maria
Published: September 2024

Currently, scientific studies have are focusing on environmentally friendly solutions, such as the effective use of waste in new green polymeric materials according to circular economy. Waste valorization is the main driving force for upcoming academic research. In this study, the impact of mussel particle size on reinforced biopoly(terphtalate ethylene) (bPET) is investigated. The waste filler was modified using NaOH. The filler content was 10 wt% and the same for all samples. The strength properties of the materials were determined in static tensile, bending and impact tests. The wetting angle was also analyzed for the obtained biocomposites. A low-cycle dynamic test was carried out to determine changes in dissipation energy and to observe the development of relaxation processes. This present study proves that preparation of new biocomposites based on waste mussels is an effective option in waste management.
Predictions of Lattice Parameters in NiTi High-Entropy Shape-Memory Alloys Using Different Machine Learning Models
Authors: Lam Tu-Ngoc , Jiang Jiajun , Hsu Min-Cheng , Tsai Shr-Ruei , Luo Mao-Yuan , Hsu Shuo-Ting , Lee Wen-Jay , Chen Chung-Hao , Huang E-Wen
Published: September 2024

This work applied three machine learning (ML) models—linear regression (LR), random forest (RF), and support vector regression (SVR)—to predict the lattice parameters of the monoclinic B19′ phase in two distinct training datasets: previously published ZrO2-based shape-memory ceramics (SMCs) and NiTi-based high-entropy shape-memory alloys (HESMAs). Our findings showed that LR provided the most accurate predictions for ac, am, bm, and cm in NiTi-based HESMAs, while RF excelled in computing βm for both datasets. SVR disclosed the largest deviation between the predicted and actual values of lattice parameters for both training datasets. A combination approach of RF and LR models enhanced the accuracy of predicting lattice parameters of martensitic phases in various shape-memory materials for stable high-temperature applications.