bluuebunny/crossref_metadata_2025 huggingface dataset:
Академическая прокрастинация студентов 1 курса: психологические аспекты и особенности
Authors: Попова Дарья И.
Published: September 2021

В статье представлены результаты исследования аспектов академической прокрастинации у студентов первого курса университета. Во Введении дано определение академической прокрастинации, представлен типичный пример ситуации, в которой находится прокрастинирующий студент, приведены подходы к пониманию природы прокрастинации, обозначены масштабы распространения данного явления и его возможные причины. Новизна исследования заключается в изучении аспектов академической прокрастинации студентов 1 курса в связи с их смысложизненными ориентациями. В разделе «Методы» описаны основные методики эмпирического исследования: авторская анкета-опросник, «Тест смысложизненных ориентаций» Д. А. Леонтьева, методика «Общий уровень прокрастинации для студентов» C. H. Lay. При обработке данных использовались U-критерий Манна-Уитни и корреляционный анализ. В исследовании приняли участие 46 обучающихся 1 курса ВУЗа в возрасте 18–21 лет. В разделе «Результаты» представлены результаты изучения особенностей академической прокрастинации по пяти направлениям: проявления, причины, эмоциональное сопровождение, последствия для учебного процесса и пути преодоления состояния прокрастинации. С помощью U-критерия Манна-Уитни определено отсутствие различий между «ситуативными» и «хроническими» прокрастинирующими студентами в связи со смысложизненными ориентациями. Проведение корреляционного анализа показало обратную значимую связь (-0,338, при r=0.05) между данными по опроснику C. H. Lay и общим уровнем осмысленности жизни по методике СЖО. В разделе «Обсуждение результатов» приведено сравнение полученных результатов с данными исследований зарубежных авторов и данными нашего предыдущего исследования. В Заключении обобщены выводы по результатам исследовании и поставлен вопрос об экспериментальном характере будущих исследований в данном направлении, что должно поспособствовать пониманию природы академической прокрастинации у студентов и способов снижения ее влияния на учебный процесс.
Pandemia-aika hoivakotiasukkaiden läheisten näkökulmasta: huolta, turhautumista ja uusia avauksia
Authors: Paananen Jenny , Rannikko Johanna , Harju Maija , Pirhonen Jari
Published: September 2021

Tutkimuksessa tarkastellaan hoivakotiasukkaiden läheisten kokemuksia koronapandemiasta. Laadullisen tutkimuksen aineistona on 41 läheisten kanssa tehtyä teemahaastattelua (794 sivua litteroituna) ja metodina aineistolähtöinen sisällönanalyysi. Tulosten perusteella vierailukiellot ja etäisyyden pitäminen ovat heikentäneet läheisten hyvinvointia sekä suhdetta asukkaaseen ja hoitotahoon. Läheiset olivat huolissaan asukkaan voinnista ja hoidosta ja kokivat tilanteen vuoksi ahdistusta, surua ja voimakasta stressiä. Moni kertoi asukkaan terveyden tai toimintakyvyn heikentyneen pandemian aikana huomattavasti, ja voinnissa tapahtuneiden muutosten uskottiin johtuvan aktiviteettien ja sosiaalisten kontaktien puutteesta. Läheiset kärsivät myös siitä, etteivät he saaneet turvavälivaatimuksen vuoksi osoittaa hellyyttä tai osallistua asukkaan hoitamiseen, kuten syöttämiseen. Vierailemista ilman yhteisiä aktiviteetteja ei aina koettu mielekkääksi, ja osa oli turhautunut epäreiluiksi kokemiensa käytäntöjen vuoksi. Läheisillä oli kuitenkin myös hyvin myönteisiä kokemuksia hoivakotien joustavasta toiminnasta ja poikkeusoloja varten kehitetyistä uusista yhteistyön muodoista. Tulokset korostavatkin tarvetta kehittää turvallisia tapoja, joilla läheiset voivat osallistua hoivakotiasukkaiden elämään ja hoivaan myös poikkeuksellisina aikoina.
Primary Hyperparathyroidism Superimposed on a Pre-existing Familial Hypocalciuric Hypercalcemia Diagnosis
Authors: Alkundi Alamin , Momoh Rabiu
Published: September 2021

Familial hypocalciuric hypercalcemia is a rare clinical condition of persistently elevated serum calcium and reduced urinary calcium levels with an autosomal dominance inheritance pattern to the three out of four large types of this condition known. This rare condition goes largely undiagnosed as patients are largely asymptomatic and where symptoms are present, other causes of hypercalcemia are considered first. Hyperparathyroidism, super-imposing on FHH, is an even rarer occurrence. We present the case of an adult male with an initial provisional assessment of FHH, which was later confirmed with a genetic study. He went on to develop hyperparathyroidism (with evident enlarged parathyroid glands on Sestamibi parathyroid scan done, and an eventual histologic diagnosis of parathyroid adenoma after surgery). It remains to be established if this is an incidental occurrence or if there is a causal relationship between FHH and an onward development of parathyroid hypertrophy or adenoma(ta).
A novel method for the evaluation of the contamination dispersing ability of lubricants (CONTA-DISP)
Authors: Ronai Bettina , Franz Rainer , Frauscher Marcella
Published: September 2021

Water and solid particulate contamination are the two most common contaminants of lubricated systems and may be highly problematic for these systems. To reduce downtime and prevent failure, lubricant formulations contain detergent and dispersant additives that play an important role in terms of contamination tolerance. In lack of a practical procedure for the determination of the relevant properties, a novel method for the evaluation of the dispersing ability of lubricating oils is introduced. Following and combining established lubricant analysis methods, a procedure with optimum parameters was found. An assessment of the method using fresh and artificially altered lubricating oils allowed a differentiation concerning their dispersing ability.
Regional marketing as capitalization tool of territory resources
Authors: Shendo Maria Vladimirovna , Sviridova Elena Viktorovna , Gordienko Svetlana O.
Published: September 2021

Any territory within the framework of its development and maintenance of the economy needs certain resources such as highly qualified workforce and external investments as the basis for creating an attractive business climate, working and living conditions. The higher the quality indicators of the economic development of the region from the point of view of territorial marketing, the higher its competitiveness and resistance to fluctuations in the economy and various markets. The fact is emphasized that regional marketing, provided that it is successfully integrated into the management of the territory, contributes to the transition of the regional economy to an innovative and socially-oriented type of economy, which today is one of the most promising from the point of view of the region’s survival in a globalized economy. The aspects of the application of regional marketing in the framework of improving the management of the territory are disclosed, and the main tasks, which it can solve regarding the promotion of a territorial product to the interregional and global market, are described. The possibilities of using regional marketing methods as effective tools for managing the process of capitalization of economic resources are determined on the example of the mechanisms of modern territorial management of the Astrakhan region. The economic indicators related to capitalization are presented, which prove the lack of investment in the economy of the Astrakhan region and the Southern Federal District, the conditions for the introduction of regional marketing as the main method of stimulating the development of the economy of the Astrakhan region are specified. Marketing strategies for the promotion and development of a territorial product have been developed, in which the process of implementing marketing technologies will be as effective as possible. There are described the tools of innovative development of the territory, based on the progressive increase in the capitalization of territorial resources, which will lead to the reorientation of the regional economy, increase the added value of the territorial product, improve the business and investment climate, and increase the competitiveness of the Astrakhan region.
Assessing impact of determinants on enterprise value in producing and processing industries
Authors: Kotova Tatyana Vladimirovna , Chernikina Elena Vladimirovna , Gladysheva Yulia Aleksandrovna
Published: September 2021

The article is devoted to studying the evaluation of the determinant factors of the value of state-owned companies, which present the competitive and investment-attractive segment of the economy with high export potential. There are considered the applied aspects of the problem and the influence of financial and non-financial factors on the value of companies, such as: return on assets, return on equity, return on invested capital, leverage, earnings per share, dividends per share, company size, company age, share of fixed assets. The research hypothesis that the selected determinants are significant and affect the value of companies with state participation are examined. The analysis is based on data from public reports of Russian producing and processing companies. The sample includes the data for 2010-2019. Companies with state participation and industry affiliation were selected; a database of indicators of financial statements of selected companies was formed; the financial indicators-factors have been calculated; the relationship of factors with the resulting indicator is determined. It has been inferred that the determinants “earnings per share” and “net working capital” are statistically significant and have an impact on the enterprise value in the industry under study
Implementing concept of smart city in Russian regions (case of Volgograd region)
Authors: Akimova Olga Evgen'evna , Volkov Sergey Konstantinovich , Kuzlaeva Irina Mikhailovna , Kozhukhova Margarita Tagirovna
Published: September 2021

The article presents the analysis of the key directions for developing a smart city concept through the prism of perception by residents participating in the strategic guidelines in the context of digitalization and a changing economic space. There has been considered the problem of implementing the concept of smart city and low awareness of residents about the regional policy on digitalization of urban space. Trigger spheres of the economy are proposed, whose digitalization should be carried out in the first place. The actual scenarios for building a smart city are presented, and their prospects for the Volgograd region are determined. A model for the development of smart urban space is proposed. The necessity of a direct financial support for advanced technological solutions for the development of urban systems through subsidies, as well as indirect tax incentives is determined. A smart city requires unconventional solutions and flexibility in municipal policies. Principles are proposed that can contribute to the sound management of sustainable smart cities. The obtained results of the study can be used by local governments to implement the most acceptable scenario for the transition to the concept of a smart city in accordance with the current level of development and preparedness of urban space for digitalization. The main advantage of the transformation of urban space and the use of digital technologies is an increase in the quality of services provided to residents, saving financial resources, time and energy required for the city functioning
PROJECT-BASED INCIDENT RATE BASED ON WEIGHTED AVERAGE METHOD
Authors: Rasmani Khairul Anwar , Yusof Noreha Mohamed , Amit Norani , Lip Norliana Mohd , Ramli Hazwani , Rosli Nur Nadiah , Rusli Anis Dayana
Published: September 2021

The incident rate has been widely used to indicate safety performance. The incident rate of a company can be compared with the national or international incident rate within similar  industry or among different type of industries. The comparison is particularly very useful as a safety benchmark to gauge performance with other companies in the same business area. However, many existing methods produce the annual incident rate, which has been formulated on an annual basis. This will lead to incompatibility of the method used in calculating the incident rate for a project that runs for a specific period. This is because the annual incident rate does not consider the duration of the project; it  becomes less meaningful in indicating the safety performance of project-based activities such as those in construction industries. The proposed method which is Project-Based Incident Rate (PIR) is found to be able to reflect the actual situation of project-based companies better than the existing annual incident rate method, and it is also can be expressed both on a monthly and yearly basis.
THE STABILITY OF THE CRITICAL POINTS OF THE GENERALIZED GAUSE TYPE PREDATOR-PREY FISHERY MODELS WITH PROPORTIONAL HARVESTING AND TIME DELAY
Authors: Wan Hussin Wan Natasha , Embong Rohana , Noor Che Noorlia
Published: September 2021

In the marine ecosystem, the time delay or lag may occur in the predator response function, which measures the rate of capture of prey by a predator. This is because, when the growth of the prey population is null at the time delay period, the predator’s growth is affected by its population and prey population densities only after the time delay period. Therefore, the generalized Gause type predator-prey fishery models with a selective proportional harvesting rate of fish and time lag in the Holling type II predator response function are proposed to simulate and solve the population dynamical problem. From the mathematical analysis of the models, a certain dimension of time delays in the predator response or reaction function can change originally stable non-trivial critical points to unstable ones. This is due to the existence of the Hopf bifurcation that measures the critical values of the time lag, which will affect the stabilities of the non-trivial critical points of the models. Therefore, the effects of increasing and decreasing the values of selective proportional harvesting rate terms of prey and predator on the stabilities of the non-trivial critical points of the fishery models were analysed. Results have shown that, by increasing the values of the total proportion of prey and predator harvesting denoted by qx Ex and qy Ey respectively, within the range 0.3102 ≤ qx Ex ≤ 0.9984 and 0.5049 ≤ qy Ey ≤ 0.5363, the originally unstable non-trivial critical points of the fishery models can be stable.
Human Germline Genome Editing: Curse or Blessing?
Authors:   Biomedical Ethics at the Faculty of Health, Medicine and Life Sciences, at Maastricht University, The Netherlands, g.dewert@maastrichtuniversity.nl, de Wert Guido
Published: September 2021

"Technological developments in genome editing raise high expectations for clinical applications, also for germline genome editing (GGE). Clinical (reproductive) GGE is currently categorically prohibited in many countries, in line with relevant European regulations. What are the arguments behind this prohibitive legislation - and are they convincing? If a technique could help to avoid serious genetic disorders in future children in a safe and effective way, would this be a reason to reconsider a categorical prohibition? Taking account of both deontological and (different types of) consequentialist ethical arguments, it is argued that: - both basic and preclinical research regarding GGE can be morally justified on conditions; - while clinical GGE would be totally premature, it might become a responsible intervention in the future, both as an add-on to and an alternative for preimplantation genetic testing (PGT) for genetic conditions, but only after adequate pre-clinical research suggesting that GGE is sufficiently safe and effective; - the categorical prohibition of clinical GGE needs critical discussion, also at a European level; - a strict regulation of clinical GGE is warranted given the relevant safety and societal concerns about unsound applications.
Medical Ethics: Uncommon Morality and the Implications for Medical Ethics Education
Authors:   ", Rhodes Rosamond ,   Professor of Medical Education and Director of Bioethics Education at Icahn School of Medicine at Mount Sinai,   Professor of Philosophy at The Graduate Center, CUNY,   Professor of Bioethics and Associate Director of the Clarkson-Mount Sinai Bioethics Program,   rosamond.rhodes@mssm.edu"
Published: September 2021

"Common morality has been the touchstone for addressing issues of medical ethics since the publication of Beauchamp and Childress’s Principles of Biomedical Ethics in 1979. In my presentation, I will challenge that reigning view by presenting two arguments. The negative argument shows why common morality cannot be the ethics of medicine. The positive argument explains why medical professions require their own ethics. I will then explain medicine’s distinctive ethics in terms of the trust that society allows to the profession. By distinguishing roles from professions, I will explicate sixteen specific duties that medical professionals undertake when they join the profession. My derivation of medicine’s distinctive ethics begins with a thought experiment demonstrating that trust is at the core of medical practice. Society allows doctors to develop special knowledge and skills and allows them to employ special powers, privileges, and immunities that could be particularly dangerous to members of society. Society, therefore, has to be assured that professional’s use of their remarkable powers and privileges will be constrained to their intended use. Professions’ publically declared codes and oaths go a long way to engender public confidence in medical professionals. Medical education must complete the job by helping our trainees understand their professional obligations and become clinicians who uphold their profession’s ethics. Medical educators therefor have to help our students comprehend and internalize their duty to “seek trust and be deserving of it,” and uphold their fiduciary responsibility to “use medical knowledge, skills, powers and privileges for the benefit of patients and society.” "
Why Goodness and Integrity in Research Matters, and Perhaps Most
Authors:   Professor of medical ethics at Center for Ethics, University of Oslo, Solbakk Jan Helge ,   Ethics expert for various international organizations (UNESCO, the European Commission, the European and Developing Countries Clinical Trials Partnership, and the Council of Europe),   j.h.solbakk@medisin.uio.no
Published: September 2021

In this key note I will address four interrelated questions: What is this ‘thing’ called goodness? Second, what kind – or type - of goodness should we strive for in research? Third, why does goodness in research matter? Fourth, what kind of goodness matters most in research, and why? These questions will be addressed by introducing a typology of goodness making it possible to differentiate between 6 distinct types of goodness. In addition, a distinction between the doing and the being of a researcher will be made use of to answer these questions.
Translating Researchers’ Experiences into Training on Research Integrity at Universities of Applied Sciences (TETRIAS)
Authors:   Junior Researcher, HAN University of Applied Sciences, Nijmegen, The Netherlands, Berentsen Susan ,   E-mail: susan.berentsen@han.nl, Blom Fenneke ,   Senior Researcher and Trainer, HAN University of Applied Sciences, Nijmegen, The Netherlands; E-mail: F.Blom@han.nl, van der Sande Rob ,   HAN University of Applied Sciences, Nijmegen, The Netherlands
Published: September 2021

"In the Dutch Universities of Applied Sciences (UASs) applied research is gaining an increasingly important place in their activities, not only as a means to improve teaching but as a means to develop innovations and professionalism as well. The establishment of a clear framework of research integrity is an important condition to foster the research environment. Up to now, in the UASs there is no specific training for researchers that helps researchers to develop the necessary competencies. This project seeks to address this issue by developing a training program on ‘Responsible Conduct of Research’. To identify what topics should be covered twelve researchers from six different UASs and seven different domains were interviewed (Economics, Arts and Culture, Pedagogy, Technology, Healthcare, Business Administration, and Bioinformatics). Their input resulted in a picture of the state of the art in integrity issues that the interviewees considered as important. Based on an explorative qualitative data analysis and the project team’s expertise tailored learning objectives and appropriate learning methods were formulated. The training program will likely be offered through the Association of UASs (Vereniging van Hogescholen) to all UASs in our country. "
Theorising and Critiquing ‘Best Interests’: A Systematic Review
Authors:   Research Fellow, University of Bristol, United Kingdom, Birchley Giles ,   E-mail: giles.birchley@bristol.ac.uk
Published: September 2021

"The ‘best interests’ standard is a key part of international law and bioethics, governing the medical treatment of children and adults who lack decision-making capacity. While the concept is used in various circumstances, ‘best interests’ has a long association with medical decision-making, appearing in English language medical journals from at least the early-19th century. Despite its history, the concept of ‘best interests’ has been fiercely criticised within bioethics and law. Critics argue that ‘best interests’ is vague and lacks specificity, and because of this, is an unchallengeable repository of medical power, and an affront to patient autonomy or parental rights. These critiques have fuelled recent calls to replace or radically reform the ‘best interests’ standard from international bodies (the Committee on the Rights of Persons with Disabilities), and national campaign groups (the Charlie Gard Foundation in the United Kingdom). This paper, undertaken as part the BABEL Wellcome Trust Collaborative Award, presents a systematic review of fifty-three theoretically rich analyses of best interests from the 1970s to the present. The discussions consider best interests primarily in clinical situations, such as withdrawal of treatment, dementia, organ donation and circumcision. They reveal a range of theories that underlie best interests including objectivism, paternalism, patient rights, pragmatism and utilitarianism. We discuss what this multiplicity of theoretical bases can reveal about the coherence of current critiques as well as the fundamental structure, and prospects of survival, of the ‘best interests’ standard. "
A Smart Ethics is an Ethics Committed to Close-Listening
Authors:   MD, Msc, University of Humanistic Studies, Utrecht, The Netherlands, Blesgraaf-Roest Bernadette ,   E-mail: bernadette.roest@phd.uvh.nl
Published: September 2021

"A ‘smart’ bioethics is an ethics that is able to recognize and address the real-life and context-embedded moral concerns of the people it intends to serve, whether those people are patients, relatives, healthcare professionals, researchers or policy-makers. Therefore, close-listening to what those people have to say, should be at the start of each bioethics-undertaking. In this presentation, I will explore how narrative approaches taken from the humanities and social sciences could help bioethicists in the 21st century to attune to and examine both the stories of others and the stories we create ourselves in medicine and bioethics. I will discuss why this is an essential first step before we embark on the normative task of bioethics, and how it entails a scrutinization of epistemological and meta-ethical positions. Following, I will use my own research project –an empirical-ethical exploration of physician-assisted dying in Dutch general practice– as an example of how narrative approaches used in empirical research, training of researchers and normative evaluation may change one’s perspective on a highly contested bioethical issue. Last, I will discuss the question whether concepts such as narrative humility and epistemic (in)justice could and should receive more attention in bioethics-training and-research. "
Advance Care Planning and Shared Decision-Making: Paving the Way
Authors:   Chair of geriatric palliative care, Lausanne University Hospital and Lausanne University, Switzerland, Bosisio Francesca ,   E-mail: francesca.bosisio@chuv.ch, Ritzenthaler Daniela ,   Lausanne University Hospital and Lausanne University, Switzerland, Rubli Truchard Eve ,   Lausanne University Hospital and Lausanne University, Switzerland, Jox Ralf J. ,   Lausanne University Hospital and Lausanne University, Switzerland
Published: September 2021

"Advance care planning (ACP) has become widely used in medical care in order to plan ahead of a loss of decision-making capacity. Since ACP aim is to promote anticipatory and substitute autonomy by engaging people ‒ and possibly their relatives ‒ in deciding about future goals of care and treatments, scientific literature in this field often posits that ACP involve shared decision-making. This assumption however is rarely backed up by an in-depth reflection on how shared decision-making might operate within ACP and which shared decision-making template is more likely to foster ACP. Our ACP tool, based on a model created at the Zurich University Hospital (Krones et al, 2019), engages patients in a structured communicational process about their values and preferences for care. In this tool, ACP facilitators help patients set goals of care and document treatments decisions in three paradigmatic situations of loss of decision-making capacity. Because our ACP tool entails discussions about goals of care, quality of life, and options in terms of disease- or symptom-management, we turned to Elwyn and al.’s three talk’s model (2012) and Vermunt et al.’s three level goal model (2018) in order to incorporate elements of shared decision-making in our ACP tool. In this presentation we discuss how these models might be combined in order to foster shared decision-making within our ACP tool and, by then, broaden its scope and eventually improve its effectiveness, strengthen its theoretical foundations and uphold the ethics of care in the event of a loss of decision-making capacity. "
Egg Donation in Art. Legal and Logical Arguments
Authors:   PhD in clinical and experimental medicine and medical humanities, University of the studies of Insubria, Varese, Italy, Capulli Emma ,   E-mail: ecapulli@studenti.uninsubria.it, Passaro Elvira ,   University of the studies of Insubria, Varese, Italy
Published: September 2021

"The procuring of eggs and compensatory measures for donors today present unresolved ethical and conceptual issues, which fuel the growth of the assisted reproductive technology (ART) industry. The speech proposes a problematization of the phenomenon from a legal point of view, supported by a rhetorical-argumentative analysis of the legal institutions. The legal provision of oocytes admits the only donation. It was deduced by analogy from the legislative provisions of available of organs and tissues (law no. 458 of 1967; law no. 301 of 1993; law no. 91 of 1999; law no. 483 of 1999), which provides for the balance between impairment of the psycho-physical sphere and goods that benefit from it. Is this balance comparable to the available of oocytes? Or does it need an autonomous redefinition? The various national regulations show that in Europe the term donation includes not only solutions of substantial gratuity, but also various forms of compensation. On one side this shows the fragility of the definition of donation, rhetorically constructed through the Aristotelian argument of the dissociation between reimbursement and remuneration, and on the other it makes clear the need to use logical-argumentative tools to disclose the criterion of hierarchization of values in game. It remains to be understood how ethical reflection, led by an argumentative legal analysis, can provide the tools to improve the functioning of a system that seems to render donors’ rights unfit for use. "
MODAL SOSIAL SEBAGAI UPAYA KEBERLANGSUNGAN USAHA DITENGAH PANDEMI COVID-19 (STUDI KASUS PADA DEBITUR ULTRA MIKRO (UMI) PT. PEGADAIAN (PERSERO) AREA LAMPUNG)
Authors: Aprilia Rini Aprilia , Gunarto Toto , Taher Arivina Ratih Yanti
Published: September 2021

The Covid-19 pandemic has not only impacted the health sector, but also in the economic and social sectors. Social restrictions and decreased purchasing power of the community led to a decrease in economic activity, especially lower-layer businesses or so-called ultra-micro enterprises. In addition to stimulus or physical capital, social capital is also required for a business sustainability. Social capital is conceptually a relational relationship obtained from social interaction between ultra-micro enterprise. Trust indicates that there is a network that shows a link between individuals or groups that interact with each other continuously so that a trust between members is formed. The network that generates benefits that lead to interdependence between members. Values and norms become the basis of the formation of social capital because it becomes the basis in the formation of a reciprocal relationship between individuals or groups. The elements contained in social capital that has the potential to be the efforts of businesses in maintaining their business. Respondents in this study numbered 85 customers, selected using random sampling. Hypothesis testing is conducted with multiple regression analysis. The results of this study are social capital positive and significant influence on the business sustainability of ultra micro debtors PT. Pegadaian (Persero) area Lampung.
DNA HASIL EKSTRAKSI DARI BERCAK SPERMA PADA KAIN KATUN DAN POLIESTER YANG DISIMPAN HINGGA 40 HARI
Authors: Yeyen Suharta I Gede , Junitha I Ketut , Alit Sukmaningsih Anak Agung Sagung
Published: September 2021

DNA adalah alat bukti penting dalam penyidikan berbasis forensik yang berguna dalam proses pemecahan dan penyelesaian kasus kriminal. Pemerkosaan adalah tindak kriminalitas yang dapat meninggalkan barang bukti berupa bercak sperma pada kain. Bercak tersebut dapat diproses agar diperoleh DNA milik pelaku, sehingga identitasnya dapat diungkap. Penelitian ini bertujuan untuk mengetahui apakah DNA dari bercak sperma pada kain berjenis katun dan poliester yang tersimpan selama 0, 20, dan 40 hari dapat diekstraksi, serta untuk mengetahui bagaimana kualitas dan kuantitas DNA yang berhasil diekstraksi dari bercak sperma tersebut. Penelitian dilaksanakan pada bulan September hingga Desember 2020 di Laboratorium Serologi dan Molekuler UPT Forensik dan Laboratorium Biomedik Terpadu Universitas Udayana. Metode penelitian terdiri dari preparasi sampel, ekstraksi DNA menggunakan Chelex 100 resin, dan kuantifikasi serta kualifikasi DNA menggunakan NanoDrop. Perolehan data kuantitas DNA dianalisis dengan metode two-way ANOVA dan chi-squared test. Hasil penelitian menunjukkan bahwa DNA dapat diekstraksi dari bercak sperma pada kain katun dan poliester yang disimpan hingga 40 hari. Kualitas dan kuantitas DNA hasil ekstraksi mengalami penurunan seiring dengan pertambahan periode masa simpan. Penurunan kuantitas DNA pada kain katun terjadi sebesar 80.42% (segar-0 hari), 12.02% (0 hari-20 hari), dan 0.78% (20 hari-40 hari). Penurunan pada kain poliester terjadi sebesar 62.16% (segar-0 hari), 11.40% (0 hari-20 hari), dan 8.47% (20 hari-40 hari). Analisa statistik terhadap kuantitas DNA menunjukkan bahwa laju penurunan konsentrasi DNA dipengaruhi oleh jenis kain yang digunakan.
STRUKTUR KOMUNITAS PLANKTON DI DANAU TAMBLINGAN KABUPATEN BULELENG BALI
Authors: Wadi Fendria , Yusup Deny Suhernawan , Suartini Ni Made
Published: September 2021

Tujuan penelitian ini adalah untuk mengetahui struktur komunitas plankton Danau Tamblingan serta aktivitas masyarakat di kawasan sekitar danau dan di badan.  Metode yang digunakan adalah metode survey dan metode kuantitatif-deskriptif. Metode survey dengan mengamati secara visual lokasi berdasarkan pemanfaatan kawasan danau. Metode kuantitatif-deskriptif dengan menggambarkan fenomena-fenomena yang didasarkan pada perhitungan dan dibandingkan dengan indeks – indeks ekologi. Hasil penelitian menunjukkan komposisi plankton terdiri atas lima filum yang di dominasi oleh filum Chlorophyta. Genus yang sering ditemukan serta kelimpahannya tinggi adalah Cosmarium, Staurastum, dan Nitzshia. Kelimpahan plankton berkisar 5.757 – 11.197 sel/liter dengan nilai indeks keanekaragaman (H’) berkisar 1,38 – 1,76 yang tergolong sedang, indeks keseragaman (E) berkisar 0,52-0,65 yang tergolong sedang, indeks dominansi (C) berkisar 0,35-0,48 menunjukkan tidak ada dominasi genus tertentu. Sebagian besar aktivitas masyarakat pada kawasan danau Tamblingan adalah sebagai petani dan nelayan. Aktivitas pertanian sangat rendah sehingga tidak berdampak terhadap perairan Danau Tamblingan.
Determination of the Earliest time Point for Heat-shock Inducing Osteoporosis-like Phenotype in the rankl:HSE:CFP Medaka Fish Model for Osteoporosis
Authors: Thuy To Thanh , Son Phan Cong , Long Tran Duc
Published: September 2021

The transgenic medaka rankl:HSE:CFP expressing Rankl, a stimulator for osteoclastogenesis - the formation and activation of osteoclasts, bone “eating” cells, under control of a heat inducible promotor has been established as a model for osteoporosis to evaluate antiosteoporosis effects of substances. Transgenic larvae were usually heat-shocked for 90 minutes at 39oC when they were at 9 days post fertilization (dpf) and osteoporosis-like phenotype was analysed when they were at 11 dpf. In this study we investigated whether osteoporosis-like phenotype could be induced in the transgenic larvae when heat-shock was applied at earlier time points, when larvae were at 1, 2, 3, 4, 5, or 6 dpf. Results showed that heat-shocks from the time point of 3 dpf onwards resulted in osteoporosis-like phenotype while heat-shock at 1 or 2 dpf did not affect mineralized bone matrix in 11 dpf larvae. These provide important evidence for study on onset of Rankl induced osteoclasts in fish and help improving experimental procedures using this fish model for osteoporosis.
The Toxicity Evaluation of Lycopodiacea Extracts by Mice Neural Cell and Zebrafish Embryo
Authors: Kien Kieu Trung , Trang Pham Thi Huyen , Thanh Nguyen Thi Kim , Dat Nguyen Tien , Thanh Nguyen Lai , Hanh Hoang Thi My
Published: September 2021

Many  species in the family Lycopodiacea possess highly potential medical substances, notably are Huperzine A of Huperzia serrata and alkaloids isolated from Lycopodium clavatum(α-Onocerin , Lycopodine,..). Various members of this family are found throughout of Vietnam and a few researches on its diversity as well as alkaloid isolation has been conducted, however, there is a lack of toxicology studies on this subject. In this study, three crude extracts (labeled AI.1, AI.2 and AI.3), which come from Lycopodium sp.collected from 3 different regions of Vietnam, have been tested on 2 toxicological models: primary neural cells derived from Swiss white mouse (in vitro) and Zebrafish (Danio rerio) embryos (in vivo). Our results show that the all three extracts are relatively low in toxicity, IC50 value on primary neural cell ranging from 800 - 1100 mg/L, while LC50 of fish embryos at 100 - 300 mg/L. AI.2 has the least effect of viability of both cells and embryos compare to the others. This data give the prove showed that the safety using Lycopodium as tradional medicine.
Te veo desde mi ventana
Authors: Lanfranco Estefania P.
Published: September 2021

El interés por la fotografía me ha llevado a los objetos y las atmósferas. Estoy atraída por la posibilidad de que en la creación de una imagen lo inerte sea capaz de suscitar sensaciones.
Dinámica familiar y enamoramiento de personas con discapacidad
Authors: Ponce Freddy
Published: September 2021

El objetivo de esta investigación es analizar teóricamente la dinámica familiar de personas con discapacidad en el proceso de enamoramiento para la conformación de una pareja. Estas personas enfrentan un entorno familiar que, por las creencias y prejuicios que sostienen, afectan negativamente su desarrollo social y afectivo. En este artículo se explora la experiencia amorosa de las personas con discapacidad paracomprender la dinámica entre la persona con discapacidad y su familia. Como respuesta al desafío que estas personas encuentran a nivel individual y familiar, a partir del marco teórico sistémico social y psicoterapéutico, se propone formas de intervención, así como pautas para el acompañamiento en el proceso de enamoramiento.
Una introducción a la psicología económica: áreas, teorías y desafíos
Authors: Rodríguez Luis
Published: September 2021

El propósito del siguiente texto es realizar una revisión de la psicología  económica como área interdisciplinar, en la cual convergen la economía y la psicología. Se delimita la conducta económica como el objeto de estudio, así como las características disciplinares y niveles de explicación científica. Además, se plantea un breve recorrido histórico por las principales figuras que aportaron significativamente a su desarrollo. Por otra parte, se describen algunas de las propuestas teóricas que tienen mayor auge en el área, unas ya conocidas, como la teoría de conducta planificada o la teoría de los dos sistemas, así como otras novedosas, entre ellas la socialización financiera o el paradigma de cursos de vida. Posteriormente, se establece la relación que podrían tener con áreas como el marketing y las políticas públicas, así como las diferencias con la economía conductual. Por último, se concluye con una serie de retos y recomendaciones para la investigación en psicología económica actualmente.
Máscaras de la muerte: las epidemias en los géneros cinematográficos
Authors: Ruiz Ortiz Baldomero
Published: September 2021

Este artículo busca dilucidar las principales características de las crisis epidemiológicas en distintos géneros cinematográficos. A manera de hipótesis, se plantea que en los filmes estudiados sobresalen dos lecturas sobre la naturaleza de las enfermedades. La primera, de corte fantástico, tiene la influencia del romanticismo. En este universo de la ficción habitan personajes monstruosos que le dan rostro a la enfermedad: el diablo, la muerte, vampiros y zombis. La segunda vertiente no incorpora elementos sobrenaturales; en cambio, enfatiza el aspecto dramático, heroico y trágico de la lucha contra infecciones, a las que se combate con las armas de la ciencia.
Parásitos mortales y Rabia: las pandemias sexuales de Cronenberg
Authors: Olivas Arana Diego
Published: September 2021

En la primera etapa de su carrera, David Cronenberg creó relatos oscuros y sangrientos sobre virus y epidemias: Parásitos mortales y Rabia. Siempre es fascinante pensar nuestro presente a partir de las primeras películas del director canadiense y su visión del body horror.
Contagios del futuro en The Twilight Zone
Authors: Honores Elton
Published: September 2021

Esta es una aproximación a dos capítulos de la serie televisiva La dimensión desconocida desconocida , llamados “El efecto placebo” y “No todos los hombres”, a propósito de su trama apocalíptica. Se aborda el miedo a los contagios virales, sea desde la fantasía extraterrestre o a partir de una mirada hacia la violencia de género.
El meme de Parásitos: el caso peruano
Authors: Gutiérrez Rafael
Published: September 2021

A partir de la última película de Bong Joon-ho, Parásitos, que muestra principalmente la desigualdad social de Corea del Sur, se han realizado diversas manifestaciones en redes sociales, entre ellas memes con gran acogida en el Perú.
Comparative evaluation of the results of an immunocytochemical study of P16/Ki-67 coexpression in patients with cervical intraepithelial neoplasia associated with human papillomavirus
Authors: Klinyshkova Tatiana V. , Samosudova Irina B. , Buyan Mariia S.
Published: September 2021

Aim. To evaluate the results of an immunocytochemical study of p16/Ki-67 double staining in the cervical epithelium of patients with cervical intraepithelial neoplasia (CIN) associated with high-risk human papillomavirus (HPVhr) in comparison with patients without cervical pathology.
Materials and methods. The comparative study included the results of examination of 75 patients divided into 4 groups. Patients with CIN1 comprised the 1st main group (n=21), women with CIN2CIN3 the 2nd main group (n=26), the comparison group consisted of patients with latent HPV infection (n=15) and the control group (n=13). The average age of women with cervical HPV infection was 26.46.13 years. Methods of investigation: liquid cytology, colposcopic, histological examination; methods for determining HPVhr DNA; immunocytochemical examination for determining double staining of p16/Ki-67 markers, statistical analysis.
Results. A positive p16/Ki-67 double staining test prevailed among patients with CIN (31.9%) compared to patients without cervical pathology (3.6%) (p=0.003) and correlated with the severity of colposcopic signs (rs=+0.397, p=0.0004). In the 1st main group of patients with verified CIN1 and in the comparison group of patients with latent infection, isolated cases of a positive test of double staining of p16/Ki-67 markers in the epithelium were recorded without significant differences between the groups (9.5 и 6.6%, p0.05). In the 2nd main group of patients with verified CIN2, CIN3, a positive test of double staining of p16 and Ki-67 was observed in every second case, dominating relative to the 1st group, the comparison group and the control group (p=0.003, p=0.005, р=0.001 respectively). In the control group, a negative double staining test was established in all cases.
Conclusion. Every second patient with CIN2+ associated with HPVhr has a positive test of double staining of the cervical epithelium, with CIN1 it is observed in 9.5% of cases (p=0.003). Among patients with CIN1, there were no differences in the expression of p16/Ki-67 in epithelial cells compared to women without cervical pathology. The data of the immunocytochemical study of p16/Ki-67 in the cervical epithelium of HPVhr positive patients with CIN should be taken into account when choosing a differentiated management strategy.
Bacterial vaginosis: modern concepts, approaches to diagnosis and treatment
Authors: Uruimagova Ada T. , Prilepskaya Vera N. , Mezhevitinova Elena A. , Donnikov Andrei E. , Ivanova Angelina A.
Published: September 2021

Microbiota a set of human microorganisms that exist with him in normal and pathological conditions, are involved in physiological and pathophysiological reactions, metabolism. The classic manifestation of a violation of the vaginal microbiota is a clinical non-inflammatory syndrome bacterial vaginosis (BV), characterized by certain changes in the composition of the vaginal microbiota and excessive reproduction of microorganisms, which are normally present in small quantities. To date, literature data emphasize that the issues of the etiology, pathogenesis of BV, the reasons for the recurrence of the process are not fully understood, the reasons for the lack of long-term effectiveness of BV therapy are unknown. Further research in this area should be aimed at studying predictors and prognostic signs of recurrence and persistence of the process, differences in vaginal microbiota in patients with recurrent and persistent BV.
Key issues in the management of adolescents and young women with heavy menstrual bleeding
Authors: Uvarova Elena V. , Salnikova Irina А. , Khashchenko Elena P. , Sokolova Arina P.
Published: September 2021

Despite high prevalence of heavy menstrual bleeding (HMB) in adolescents and young women, most recommendations are not specific for this population, which makes the diagnosis and management challenging. Gynecologists should be able to establish underlying causes of HMB, which most common are nonstructural in adolescents, and the severity of bleeding, to provide early diagnosis, using appropriate therapy for improving quality of life and iron deficiency prevention. First line management consists of hormonal therapy approved for HMB treatment, capable to normalize menstrual blood loss and iron metabolism parameters.
Mastalgia in infertility: search for additional possibilities of therapy
Authors: Krasnopolskaya Ksenia V. , Balan Vera E. , Ershova Irina Y. , Skorik Elena O. , Malygin Sergey E. , Orazov Mekan R. , Toktar Lilia R. , Lagutina Elena V.
Published: September 2021

Aim. To assess the efficacy and safety of using the homeopathic drug Mastopol for the relief of mastalgia in women with infertility, including those associated with endometriosis, as well as to study the drug tolerability and adherence to the treatment, as well as to determine its antiproliferative and analgesic effects in patients of the study cohort. Study design: open-label, randomized, non-comparative, observational study.
Material and methods. 79 infertile women with mastalgia (67 with cyclic mastalgia and 12 with acyclic mastalgia) were examined and treated with Mastopol. Mastopol was prescribed 1 tablet 3 times a day sublingually. The course of treatment was 8 weeks. The efficacy of mastalgia relief was assessed using a Visual Analogue Scale (VAS). Treatment outcomes were considered good if pain severity by the VAS decreased by 4 or more points from the baseline levels at the end of Mastopol treatment course.
Results. One Mastopol treatment course provided good treatment outcomes in 76,2% of patients with cyclic mastalgia and in 33,3% of patients with acyclic mastalgia. There were no adverse reactions or complications in patients treated with Mastopol.
Conclusions. Mastopol has established itself as a quite effective and safe drug in patients of the study cohort; if there is an insufficient effect, Mastopol can supplement traditional pharmacological agents recorded in the current clinical guidelines.
Stress-protective effects of micronized progesterone in treatment of anxiety disorders in pregnant women after in vitro fertilisation
Authors: Tapilskaya Natalya I. , Nekrasov Mikhail S. , Krikheli Inna O. , Ob'edkova Ksenia V. , Gzgzyan Alexander M. , Kogan Igor Y. , Glushakov Ruslan I.
Published: September 2021

Aim. To study a stress-protective efficacy of micronized progesterone (MP) in pregnant women with anxiety disorders after in vitro fertilisation (IVF).
Materials and methods. We conducted a prospective, comparative open-label randomized trial in two IVF-clinics. A total of 98 pregnant women after IVF with anxiety disorders were recruited at the 9th week of pregnancy. Progesterone supplementation after IVF for luteal phase support was administered out until 9 weeks gestation. Then, after randomization, group 1 (n=35) received 400 mg per day of MP vaginally, group 2 (n=33) received 400 mg of MP orally, group 3 (n=30) was comparative for the other groups. The duration of progesterone treatment was 12 weeks. The Spielberger State Trait Anxiety Inventory (STAI), the Montgomerysberg depression rating scale (MADRS), Hospital Anxiety and Depression Scale (HADS), and the Epworth Sleepiness Questionnaires (ESQ) were used to compare maternal mood at 9 weeks (day of randomization) after delivery and at 283, 565, 847 days after randomization.
Results. The mean STAI sumscore in MP-groups was significantly lower than in group 3 starting from day 565 and continued until the end of the study. There were no significant differences between vaginal and oral administration of progesterone. There were no significant differences between the mean sumscores when questioning on the HADS, MADRS and ESQ.
Conclusion. Prolonged use of MP in pregnant women with anxiety disorders led to the prevention of manifestations of an increase in anxiety and depression. The stress-protective and neuromodulating properties of MP can determine additional indications for its prolonged administration in women with anxiety disorders and/or premorbid history.