bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementation of an anaerobic selector step for the densification of activated sludge treating high-salinity petrochemical wastewater
Authors: Poelmans Sven , Dockx Lennert , Seguel Suazo Karina , Goettert Dorothee , Dries Jan
Published: February 2023

Sludge bulking is a common challenge in industrial biological wastewater treatment. Leading to difficulties such as bad sludge settling and washout, which is a problem also encountered in the petrochemical industry. Anaerobic feeding strategies can be used to induce the growth of storage-capable organisms, such as glycogen-accumulating organisms (GAO), leading to denser sludge flocs and better settling. In this study, the implementation of an anaerobic feeding strategy was investigated for high-salinity petrochemical wastewater (±35 g salts·L−1), using a sequencing batch reactor. Influent, effluent and sludge characteristics were analyzed throughout the operational period, which can be divided into three stages: I (normal operation), II (increased influent volume) and III (longer anaerobic mixing). Good effluent quality was observed during all stages with effluent chemical oxygen demand (COD) < 100 mgO2·L−1 and removal efficiencies of 95%. After 140 days, the sludge volume index decreased below 100 mL·g−1 reaching the threshold of good settling sludge. Sludge morphology clearly improved, with dense sludge flocs and less filaments being present. A maximum anaerobic dissolved oxygen carbon (DOC) uptake was achieved on day 80 with 74% during stage III. 16S rRNA amplicon sequencing showed the presence of GAOs, with increasing relative read abundance over time from 1 to 3.5%.
Sustainability assessment of retrofitting alternatives for large and old wastewater treatment plants in Seoul
Authors: Kwon Soonwon , Zhang Chuanli , Oh Jeill , Park Kyoohong
Published: February 2023

Old wastewater treatment plants (WWTPs) must be upgraded to alleviate the problems associated with aging and reduce their total environmental impacts. To enhance the environmental sustainability in retrofitting large and old WWTPs, the decision-making process for selecting the most appropriate alternative is complicated. In this study, evaluation criteria were proposed to select the most sustainable alternatives for mid- to long-term retrofitting plans for a large WWTP with the treatment capacity of 1.6 M m3/d, which is initially built in 1987. An analytic hierarchy process was applied to estimate the weights of each criterion. Fourteen experts evaluated the relative importance of criteria through pairwise comparisons. In order to assess the current retrofitting opinions, three retrofitting alternatives were constructed: A focused on energy sufficiency; B expanded the bioreactor capacity and enhancement of the facility for incinerating the sludge leaving the anaerobic digestor; C emphasized the treatment of contaminants of emerging concerns (CECs). A achieved the highest score (0.623) owing to the environmental benefits associated with recycling and first flush stormwater treatment. C exhibited the second highest score (0.612) as the focus on CECs removal. B corresponded to the lowest sustainability (0.426), with the lowest scores pertaining to effective land use and first flush stormwater treatment.
Early T-cell precursor leukemia: questions of diagnosis, treatment and description of own clinical case
Authors: Korkina Yu. S. , Valiev T. T. , Kirgizov K. I. , Varfolomeeva S. R.
Published: February 2023

Early T-cell precursor leukemia (early T-cell precursor, ETP-ALL) is a new subvariant of acute lymphoblastic leukemia (ALL). Tumor blasts have a unique phenotype, including signs of both stem and myeloid cells. This fact significantly complicates differential diagnosis. Cytogenetic and molecular biological features of cells in ETP-ALL are the most important diagnostic criteria. Nowadays the leading scientific international groups of pediatric leukemia conduct researches to develop new treatment protocols for ETP-ALL or to optimize existing chemotherapy regimens by including targeted drugs (bortezomib, ruxolitinib, venetoclax). Currently, hematopoietic stem cell transplantation is a mandatory option in the treatment of ETP-ALL. Targeted drugs and CAR-T-cell (chimeric antigen receptor of T-cells) therapy are the most perspective ways of posable treatment. In this article there are summarized data on diagnosis and therapy and a description of a successful treatment of a patient with ETP-ALL.
Resolution on the results of the Council of Experts on the topic: “Infantile hemangioma is an interdisciplinary problem that has a unified solution: from detection/diagnosis and treatment to reimbursement”
Authors: Belysheva T. S. , Varfolomeeva S. R. , Zakharova I. N. , Zuev A. V. , Katukova N. P. , Polyaev Yu. A. , Fedyaeva V. K. , Kyrgyzov K. I. , Sagoyan G. B.
Published: February 2023

On October 19, 2022, the Council of Experts considered and discussed a number of issues related to the treatment of patients with infantile hemangioma in the Russian Federation.
Reconstructive vascular surgery in pediatric oncology: literature review
Authors: Gurgenidze N. N. , Popov G. I. , Kutenkov A. A. , Trushin A. A. , Zayceva A. N. , Shvetsov A. N. , Kazantsev I. V. , Zakharenko A. A.
Published: February 2023

Background. In some rare cases pediatric solid tumors may infiltrate or incase major vessels, which may require vascular plastics as part of radical tumor resection. As these situations are rare in pediatric surgeon practice, there is no common approach to this problem. In order to analyze the available experience we reviewed published cases concerning vascular plastics in pediatric oncosurgery.   Materials and methods. The references from MEDLINE (PubMed), HighWire Press, and eLibrary electronic databases were analyzed for references describing practical vascular surgery experience with vascular implants published in 2002–2022.   Results. There is few published data on major vessels reconstruction in patients with pediatric solid tumors. Most publications describe single cases or small case series. The vascular plastics in these children is difficult due to small vessel diameter, difficulties in choosing the right graft, risk of thrombosis, and the need to provide adequate circulation in a rapidly growing child. As there are no major studies of this subject we still have no consensus on optimal vascular reconstruction tactics in children with solid tumors. Therefore, new systematic studies are needed.   Conclusion. We provide a brief review on currently used methods of vascular plastics and reconstruction available for use in children with solid tumors.
Therapeutic Potential of Thiophene Compounds: A Mini-Review
Authors: Chawla Shivani , Sharma Shweta , Kashid Sarfraj , Verma Prabhakar Kumar , Sapra Ashu
Published: February 2023

A rising number of researchers are interested in thiophene-based analogs as they have wide
possibilities of biological potential in the largely developing chemical world of the heterocyclic moiety.
It also occupies a central position in synthetic organic chemistry and is of the highest theoretical
and practical importance. It became an important moiety for researchers to discover combinatorial
libraries and implement the efforts in search of the lead entity. Moreover, it helps medicinal chemists
to improve sophisticated molecules with a broad range of pharmacological activities. Thiophene and
its synthetic derivatives are a prominent heterocyclic compound class with intriguing uses in medical
chemistry. It has been manifesting to be an effective drug in current respective diseases scenario. It
has been discovered that thiophene had an extensive spectrum of pharmacological potential with numerous
applications in academic interest, in the pharmaceutical industry, material science, and medicinal
chemistry. Antimitotic, antimicrobial, anti-inflammatory, anticonvulsant, antipsychotic, antiarrhythmic,
anti-anxiety, antifungal, antioxidant, estrogen receptor regulating, and anti-cancer are one
of the pharmacological and physiological activities of thiophene moiety. However, there are some
marketed formulations available such as Thiophenfurin, Teniposide, Cefoxitin, Ticaconazole,
Sertaconazole, Suprofen, ketotifen, Brinzolamide, Dorzolamide, Tiotropium which contain thiophene
nucleus. Thus, in brief, gathering recent data is necessary to comprehend the present scenario of thiophene
moiety for scientific research purposes and highlights a broad view of the biological potential
of compounds having a thiophene nucleus.
Digital Intervention for the Management of Alzheimer’s Disease
Authors: Manchanda Namish , Aggarwal Akanksha , Setya Sonal , Talegaonkar Sushama
Published: February 2023

Alzheimer’s disease (AD) is a progressive, multifactorial, chronic, neurodegenerative disease with high prevalence and limited therapeutic options, making it a global health crisis. Being the most common cause of dementia, AD erodes the cognitive, functional, and social abilities of the individual and causes escalating medical and psychosocial needs. As yet, this disorder has no cure and current treatment options are palliative in nature. There is an urgent need for novel therapy to address this pressing challenge. Digital therapeutics (Dtx) is one such novel therapy that is gaining popularity globally. Dtx provides evidence based therapeutic interventions driven by internet and software, employing tools such as mobile devices, computers, videogames, apps, sensors, virtual reality aiding in the prevention, management, and treatment of ailments like neurological abnormalities and chronic diseases. Dtx acts as a supportive tool for the optimization of patient care, individualized treatment and improved health outcomes. Dtx uses visual, sound and other non-invasive approaches for instance-consistent therapy, reminiscence therapy, computerised cognitive training, semantic and phonological assistance devices, wearables and computer-assisted rehabilitation environment to find applications in Alzheimer's disease for improving memory, cognition, functional abilities and managing motor symptom. A few of the Dtx-based tools employed in AD include "Memory Matters", "AlzSense", "Alzheimer Assistant", "smart robotic dog", "Immersive virtual reality (iVR)" and the most current gamma stimulation. The purpose of this review is to summarize the current trends in digital health in AD and explore the benefits, challenges, and impediments of using Dtx as an adjunctive therapy for the management of AD.
Pesticide Exposure and Alzheimer’s Disease: A Case-control Study
Authors: Kiani Zohreh , Asadikaram Gholamreza , Faramarz Sanaz , Salimi Fouzieh , Ebrahimi Hosseinali
Published: February 2023

Purpose:

This study aimed to investigate the levels of organochlorine pesticides (OCPs) in the serum of Alzheimer's disease (AD) patients.

Methods:

63 AD patients and 50 healthy individuals participated, and the levels of some OCPs derivatives (including; α-HCH, β-HCH, γ-HCH, 2,4-DDT, 4,4-DDT, 2,4-DDE, and 4,4-DDE), total antioxidant capacity (TAC), protein carbonyl (PC), malondialdehyde (MDA), Nitric oxide (NO) along with the activity of superoxide dismutase (SOD), glutathione peroxidase (GPx), paraoxonase 1(PON1), and acetylcholinesterase (AChE) were measured.

Results:

The mean OCP level of OCPs in AD patients was significantly higher than in the control group. However, the patients' mean levels of TAC, PC, MDA and activity of SOD, GPx, PON1 and AChE were significantly lower than controls. A significant positive correlation was also observed between 2,4-DDE and MDA and between γ-HCH and PC in AD patients. These findings showed that pesticide exposure is associated with an increased risk of AD. Furthermore, the mean levels of oxidative stress markers, which may result from pesticide exposure, were significantly lower in AD patients compared to healthy individuals.

Conclusion:

Therefore, it may conclude that pesticides, at least in part, contribute to AD development through several mechanisms, including the induction of oxidative stress.

conclusion:

These results suggest that pesticides contribute to AD development, at least in part, through several mechanisms, including induction of oxidative stress.
Application of Improved Support Vector Machine for Pulmonary
Syndrome Exposure with Computer Vision Measures
Authors: Khadidos Adil O. , Alshareef Abdulrhman M. , Manoharan Hariprasath , Khadidos Alaa O. , Selvarajan Shitharth
Published: February 2023

Background:

In many medically developed applications, the process of early diagnosis in
cases of pulmonary disease does not exist. Many people experience immediate suffering due to the lack
of early diagnosis, even after becoming aware of breathing difficulties in daily life. Because of this,
identifying such hazardous diseases is crucial, and the suggested solution combines computer vision and
communication processing techniques. As computing technology advances, a more sophisticated mechanism
is required for decision-making.

Objective:

The major objective of the proposed method is to use image processing to demonstrate computer
vision-based experimentation for identifying lung illness. In order to characterize all the uncertainties
that are present in nodule segments, an improved support vector machine is also integrated into the
decision-making process.

Methods:

As a result, the suggested method incorporates an Improved Support Vector Machine (ISVM)
with a clear correlation between various margins. Additionally, an image processing technique is introduced
where all impacted sites are marked at high intensity to detect the presence of pulmonary syndrome.
Contrary to other methods, the suggested method divides the image processing methodology into
groups, making the loop generation process much simpler.

Results:

Five situations are taken into account to demonstrate the effectiveness of the suggested technique,
and test results are compared with those from existing models.

Conclusion:

The proposed technique with ISVM produces 83 percent of successful results.
Newly Synthesized Arylazo Derivatives Induce Apoptosis and G2/M Cell Cycle Arrest
With Molecular Docking Validation in Human Cancer Cell Lines
Authors: Laboud Yara N. , Hassan Nourhan , Hassaneen Hamdi M. , Hassaneen Huwaida M. E. , Saleh Fatma M. , Mohamed Teleb Mohamed A.
Published: February 2023

Objective:

We reported herein the synthesis of novel arylazo derivatives 3a-e incorporating isoquinoline
moiety.

Methods:

A coupling reaction of 2-(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)acetonitrile 1 with diazotized heterocyclic
amines 2 in ethanol in the presence of sodium acetate to give arylazo derivatives 3a-e.

Results:

Cytotoxic effect of five arylazo derivatives on breast carcinoma MCF7 and hepatocellular carcinoma HepG2
was carried out, followed by molecular and functional-based assays, to estimate the anticancer effect of these compounds.
The fibroblast growth factor receptor (FGFR) and epithelial growth factor receptor (EGFR) were found to
interact and bind with the compounds 3a and 3d through several hydrophobic and hydrogen bonds, which were validated
by molecular docking.

Conclusion:

The two promising compounds 3a and 3d demonstrated various anticancer potential activities on tumorigenesis,
cytotoxicity, and apoptotic effects, exhibited in the deregulation of the expression of different genes involved
in apoptotic and anti-apoptotic mechanisms, cell cycle arrest at G2/M, and induction of apoptosis in both cell lines.
Development of an Isothermal Point-of-care Genetic Rapid Test for
the Detection of the HLA-B*57:01 Allele, a Predictor for Hypersensitivity
Reaction Caused by Abacavir, for Stratifying Patients for Antiretroviral
Abacavir HIV Therapy
Authors: Jacobsen Alexander E. , Jüngling Antje , Gorges Corinna , Eidens Moritz
Published: February 2023

Background:

Abacavir is used in the treatment of HIV-infected patients. A hypersensitive
reaction (HSR) occurs in about 5-8% of patients treated with Abacavir. The
HLA-B*57:01 allele is a valuable predictor for HSR and its screening is mandatory prior to
treatment with Abacavir.

Objective:

Current screening methods require considerable investments for equipment. In
order to lower the required investments and enable physician practices to perform the
screening in a point-of-care (PoC) setting, our objective was to develop a novel isothermal
genetic rapid test that requires a minimal setup cost, does not require specific training and
thus is suitable for a physician practice setting.

Methods:

We developed an isothermal recombinase polymerase amplification (RPA) for the
specific amplification of the HLA-B*57:01 allele using allele-specific primers coupled to Biotin.
Primers specific for human lactase gene, coupled to Digoxigenin, were used as an internal
amplification control (IAC). Lateral flow dipstick provided rapid and accurate detection of
HLA-B*57:01 allele and IAC via the respective antibodies sprayed on the strips surface.

Results:

The reference method identified the HLA-B*57:01 allele in the reference sample,
in 2 out of 28 buccal swab samples and in 2 out of 13 blood samples. The initial isothermal
RPA resulted in unspecific amplification of the HLA-B*57:01 allele. By further optimization
steps the specific amplification of the allele and the detection on lateral flow dipstick
was observed. The newly developed isothermal RPA was validated.

Conclusion:

The method developed fulfils the requirements for a genetically based PoC
screening system for the HLA-B*57:01 variant, requiring a minimal investment for a heating
block and a pipette.
Biogenic Nanoparticles: Synthesis, Characterization, and Biological Potential
of Gold Nanoparticles Synthesized using Lasiosiphon eriocephalus
Decne Plant Extract
Authors: Datkhile Kailas D. , Durgawale Pratik P. , Chakraborty Shuvronil , Jagdale Nilam J. , More Ashwini L. , Patil Satish R.
Published: February 2023

Introduction:

Recent advancements in biomedicine have revolutionized nanomedicine
as a therapeutic moderator in the management of both infectious and noninfectious diseases.

Purpose:

In the current study we demonstrated biosynthesis of gold nanoparticles using aqueous
leaf extract of Lasiosiphon eriocephalus as a capping and reducing agent and evaluation of their
antioxidant, antibacterial, and anticancer properties.

Methods:

The biosynthesized LE-AuNPs were characterized by UV-Vis spectrophotometry,
SEM, TEM, XRD, FTIR, DLS, and Zeta potential analysis. The antibacterial activity was
checked by a minimum inhibitory concentration assay. The anticancer potential of biogenic
LE-AuNPs was checked by cytotoxicity and genotoxicity assay against HeLa and HCT-15 cells.

Results:

The characteristic surface plasmon resonance peak of the colloidal solution at 538 nm
by UV-Vis spectrum confirmed the formation of LE-AuNPs in the solution. The SEM, TEM, and
XRD revealed 20-60 sized hexagonal and crystalline LE-AuNPs. The LE-AuNPs displayed significant
inhibition potential against DPPH and ABTS radicals in vitro. The LE-AuNPs demonstrated
significant antibacterial potential. The results of cytotoxicity interpreted that biogenic
gold nanoparticles exhibited strong dose and time-dependent cytotoxicity effect against selected
cancer cell lines where IC50 of LE-AuNPs required to inhibit the growth of HeLa cells after 24 h
and 48 h exposure were 5.65± 0.69 μg/mL and 4.37±0.23 μg/mL respectively and that of HCT-
15 cells was 6.46 ± 0.69 μg/mL and 5.27 ± 0.34 μg/mL, 24h and 48h post-exposure respectively.

Conclusions:

Findings from this study revealed that gold nanoparticles synthesized using L. eriocephalus,
showed remarkable antioxidant, antimicrobial, and extensive cytotoxicity and genotoxicity
activities.
STRATEGY TO STRENGTHEN THE LEGALITY SUPERIOR PRODUCTS IN PENGADAH VILLAGE, NATUNA REGENCY
Authors:   Faculty of Engineering, University of Brawijaya, Malang, 65145, East Java, Indonesia, Sugeng Widodo Agung
Published: February 2023

As an archipelagic country, Indonesia has border areas with neighboring countries. Natuna Regency is one of the outermost regions of Indonesia administratively bordering three countries, namely Vietnam, Cambodia, and Malaysia. The geographical location in the middle of the North Natuna Sea, problems with climate influences is very vulnerable to occur in the agricultural and fishery potential development in Natuna Regency. The majority of the livelihoods of the Pengadah Village residents are fishermen. Implementing the Research Program by the Institute of Research and Community Service, Universitas Brawijaya in Pengadah Village, Northeast Bunguran District, Natuna Regency has entered its 4th year (2021) with the topic of strengthening the institutional and legality for superior products. The Research Program carried out institutional strengthening and legality of superior village products through marketing and branding content training activities, making souvenirs from seashells, developing Geopark tourism, assisting marine cuisine and preparing legal legality for Village Owned Enterprises, Tourism Awareness Group and Batik SMEs. The acceleration of Pengadah Village to become an independent village in the National Border area requires cooperation between Universitas Brawijaya and the local Natuna Regency Government.
THE DESIGN OF TEMPERATURE CALIBRATION BATH USING THE QUALITY FUNCTION DEPLOYMENT (QFD) APPROACH
Authors:   Industrial Engineering, Universitas Brawijaya, Indonesia, Oktavianty Oke
Published: February 2023

A temperature calibration bath is a calibrator with a uniform liquid enclosure that can be set to a certain temperature for the test point. In this study, a product design was carried out to make a temperature calibration bath instrument by modifying several parts so that it could achieve the desired temperature interval. The QFD approach was used to design tools that are in accordance with the Voice of Customer, among which are a wide temperature range, rust-resistant materials, ease of maintenance and operation, high accuracy, and affordable prices. Furthermore, the design also considered ease of reading the instrument, uniformity and stability of temperature, and speed of temperature change using the appropriate propeller and stirrer. The technical response was determined systematically to fulfil the customer’s wants and needs until the specifications of temperature calibration bath with oil operating fluid was decided.
ANALYSIS OF ALCOHOL AND SUGAR LEVELS IN KOMBUCHA WITH GREEN TEA AT UKM DEE PARFAIT USING MQ3 AND PHOTODIODES SENSORS
Authors:   Agricultural Technology Faculty, Brawijaya University, Malang, East Java, Indonesia, Endelita Musdian Magita
Published: February 2023

Kombucha tea is a fermented drink between sugar and tea with a starter culture called SCOBY which can trigger an increase in body immunity and is rich in nutrients. Kombucha Tea at UKM Dee Parfait uses green tea as raw material which is fermented using SCOBY starter culture using 200 grams of sugar. Testing the sugar content in kombucha tea can take advantage of the phenomenon of optical substances, where when polarized light passes through a solution containing sugar groups, the light will rotate because it can change the direction of the light and will be captured by the photodiode sensor. Testing the alcohol content using the MQ3 sensor, this gas sensor is sensitive to detect the ethanol content that evaporates in the free air. Analysis of alcohol and sugar content can be determined by linear equations. Based on the results of research from the green tea leaves kombucha tea product of UKM Dee Parfait by using the MQ3 sensor to detect alcohol content, a linear equation of alcohol content was obtained y=0,115x-3,565, while using a photodiode sensor to detect sugar content obtained a linear equation of sugar content y=0,23-7.13.
PHYSICAL AND CHEMICAL CONTENTS ANALYSIS OF PHYLLANTHUS URINARIA POWDER AS HERBAL BEVERAGES
Authors:   Faculty of Agricultural Technology, Universitas Brawijaya, Jl. Veteran, Faculty of Agricultural Technology  Universitas Brawijaya, Malang 65145, Indonesia, Atsari Dewi Ika
Published: February 2023

The development of Indonesian heritage herbal beverages from traditional forms to powder herbal beverages which are processed into powder or beverage form is expected to be able to improve the quality of these herbal beverages. This herbal drink has several health benefits such as the presence of antioxidant compounds that can scavenge free radicals to maintain immunity. The powdered herbal drink is made to make it easier to consume, efficiently, and maintain health. This study aims to produce herbal beverages from herbal medicine from commodities of meniran, ginger, java ginger, lemongrass, and palm sugar to determine the physical, chemical, and antioxidant activity of powder herbal beverages. The research method used foam mat drying with herbal formulas in the form of meniran, ginger, java cucumber, lemongrass, and palm sugar. This study was observed with several parameters, namely physical analysis with pH measurement, chemical analysis of moisture content and ash content, and analysis of DPPH antioxidant activity. The form of the product is a powdered powder herbal drink based on SNI standards the quality of traditional powdered beverages. The results obtained in comparing four samples of herbal drink powder from the parameters of the optimum moisture content, ash content, pH and antioxidant activity were, respectively, 2.72%; 3,63%; 6.31; 5.33 μg/ml.
IMPLEMENTATION OF INNOVATION 4.0 THROUGH THE DEVELOPMENT OF DIGITAL START UPS MALANG GO
Authors:   Department of Management, Faculty of Economis and Business Brawijaya University, Palupi Prabandari Sri
Published: February 2023

The development of science and technology give impact for society. Nowadays, technology and humans have become an inseparable part. People use technology especially in digital technology to make easily and simplify the work. Digital technology provides services to access various information and services to support human activities. Creators strive to develop innovation and creativity in digital technology more broadly. Digital technology innovations have also been developed to improve business service activities. The innovation in business is needed to enlarge the market, optimize distribution channels, and maximize business productivity. Therefore, digital services or platforms are indispensible needed for business development, especially on a micro scale. MSME managers can use digital technology, one of which is in their distribution and logistics channels. Digital technology innovation can be embedded in the request process and between products to customers. In addition, and delivery services can also be applied to ordering and delivering raw materials from suppliers. By using digital technology for distribution and logistic it will increase efficiency and productivity of MSMEs. Responding to the problems that arise, Malang Go become a digital technology innovation to increase the efficiency and productivity of MSMEs in Malang City. Malang Go offers delivery or courier services for products produced by MSMEs. Malang Go has excellent services that support the sustainability of MSME business in Malang City and does not set high-cost services and increases the price of products produced by MSMEs. This Start Up only charges administration fees to MSME partners every 6 months. Thus, MSME owners can increase efficiency and productivity in the business they run. This is one of the advantages of Malang Go application compared to other similar applications.
Case Study Of Dft (Deep Flow Technique)- Nft (Nutrient Flow Technique) Hydroponic Planting Patterns In First Middle School Students State 1 And 5 Karangploso Malang
Authors:   Department of Agricultural Engineering, Faculty of Agricultural Technology Universitas Brawijaya, Wahyu  Indriani Dina , Kresna  Maharsih Inggit , Wahyu  Putranto Angky , Wibisono Yusuf , Dwi Argo ambang , Lastriyanto Anang
Published: February 2023

Farming patterns for urban residents to cultivate crops is a difficult thing to do because of limited land. Currently, the pattern of building residents of the city is apartments and minimalist housing where residents have a narrow land area, critical landconditions and limited amount of water. Therefore, a solution is needed so that city residents can cultivate crops. Based on this, the hydroponic planting pattern is a good alternative for city residents so that they can continue to grow crops in their surrounding environment. The Deep Flow Technique (DFT) method combined with the Nutrient Film Technique system. The purpose of this service activity is the first to organize training on the manufacture of simple DFT-NFT hydroponics, with methods and materials that are safe to use and serve as material for debriefing and providing entrepreneurial motivation for community groups in Malang district. The implementation of this service is at SMP N 1 and SMPN 5 Karangploso, Malang Regency. The webinar participants were attended by 61participants consisting of 8th and 9th grade students, accompanying teachers, and a team of service lecturers. As for the results of this activity 81% of the webinar participants are familiar with the pattern of farming using the DFT NFT hydroponic system well. So that participants have benefited from this activity and these academics are able to apply knowledge to society significantly
The Dynamics of the Oceanic Air-Sea Boundary Layer
Authors: Bye John A. T.
Published: February 2023

This paper presents a model for the similarity structure of the velocity profiles in air and water in the wave boundary layer, which provides predictions in terms of two parameters, F and R, of all its important properties, including the Charnock parameter, the surface drift velocity and the condition for the cancellation of the surface Stokes velocity by the surface current. The parameter, F, arises from the fetch variability of the wave field, and the parameter, R, arises from the duration variability of the wave field. In the analysis two regimes emerge, namely the Ekman regime and the Hasselmann regime. In the Ekman regime, which occurs for R > ½(1 + F), there is a net loss of energy from the wave field to the deep ocean, and in the Hasselmann regime which occurs for R < ½(1 + F), there is a net gain of energy from the atmosphere to the wave field. The predictions are compared with observations from classical wave formulae, wind-wave studies, and also ROMS and SWAN modelling in the South Australian Basin. A general conclusion is that the condition, F = 1, which was used in the original inertial coupling model of Bye [1], is a good approximation for large scale theoretical ocean studies, and hence the wind-wave interaction is determined principally by R.
Improving Communication in Intensive Care Unit to Ward Transitions: Protocol for Multisite National Implementation of the ICU-PAUSE Handoff Tool
Authors: Fukui Elle Mizuki , Lyons Patrick G , Harris Emily , McCune Emma K , Rojas Juan C , Santhosh Lekshmi
Published: February 2023

Background

The intensive care unit (ICU)–ward transfer poses a particularly high-risk period for patients. The period after transfer has been associated with adverse events and additional work for care teams related to miscommunication or omission of information. Standardized handoff processes have been found to reduce communication errors and adverse patient events in other clinical environments but are understudied at the ICU-ward interface. We previously developed an electronic ICU-ward transfer tool, ICU-PAUSE, which embeds the key elements and diagnostic reasoning to facilitate a safe transfer of care at ICU discharge.

Objective

The aim of this study is to evaluate the implementation process of the ICU-PAUSE handoff tool across 10 academic medical centers, including the rate of adoption and acceptability, as perceived by clinical care teams.

Methods

ICU-PAUSE will be implemented in the medical ICU across 10 academic hospitals, with each site customizing the tool to their institution’s needs. Our mixed methods study will include a combination of a chart review, quantitative surveys, and qualitative interviews. After a 90-day implementation period, we will conduct a retrospective chart review to evaluate the rate of uptake of ICU-PAUSE. We will also conduct postimplementation surveys of providers to assess perceptions of the tool and its impact on the frequency of communication errors and adverse events during ICU-ward transfers. Lastly, we will conduct semistructured interviews of faculty stakeholders with subsequent thematic analysis with the goal of identifying benefits and barriers in implementing and using ICU-PAUSE.

Results

ICU-PAUSE was piloted in the medical ICU at Barnes-Jewish Hospital, the teaching hospital of Washington University School of Medicine in St. Louis, in 2019. As of July 2022, implementation of ICU-PAUSE is ongoing at 6 of 10 participating sites. Our results will be published in 2023.

Conclusions

Our process of ICU-PAUSE implementation embeds each step of template design, uptake, and customization in the needs of users and key stakeholders. Here, we introduce our approach to evaluate its acceptability, usability, and impact on communication errors according to the tenets of sociotechnical theory. We anticipate that ICU-PAUSE will offer an effective handoff tool for the ICU-ward transition that can be generalized to other institutions.

International Registered Report Identifier (IRRID)

DERR1-10.2196/40918
Tracking Population-Level Anxiety Using Search Engine Data: Ecological Study
Authors: Gilbert Barnabas James , Lu Chunling , Yom-Tov Elad
Published: February 2023

Background

Anxiety disorders are the most prevalent mental disorders globally, with a substantial impact on quality of life. The prevalence of anxiety disorders has increased substantially following the COVID-19 pandemic, and it is likely to be further affected by a global economic recession. Understanding anxiety themes and how they change over time and across countries is crucial for preventive and treatment strategies.

Objective

The aim of this study was to track the trends in anxiety themes between 2004 and 2020 in the 50 most populous countries with high volumes of internet search data. This study extends previous research by using a novel search-based methodology and including a longer time span and more countries at different income levels.

Methods

We used a crowdsourced questionnaire, alongside Bing search query data and Google Trends search volume data, to identify themes associated with anxiety disorders across 50 countries from 2004 to 2020. We analyzed themes and their mutual interactions and investigated the associations between countries’ socioeconomic attributes and anxiety themes using time-series linear models. This study was approved by the Microsoft Research Institutional Review Board.

Results

Query volume for anxiety themes was highly stable in countries from 2004 to 2019 (Spearman r=0.89) and moderately correlated with geography (r=0.49 in 2019). Anxiety themes were predominantly long-term and personal, with “having kids,” “pregnancy,” and “job” the most voluminous themes in most countries and years. In 2020, “COVID-19” became a dominant theme in 27 countries. Countries with a constant volume of anxiety themes over time had lower fragile state indexes (P=.007) and higher individualism (P=.003). An increase in the volume of the most searched anxiety themes was associated with a reduction in the volume of the remaining themes in 13 countries and an increase in 17 countries, and these 30 countries had a lower prevalence of mental disorders (P<.001) than the countries where no correlations were found.

Conclusions

Internet search data could be a potential source for predicting the country-level prevalence of anxiety disorders, especially in understudied populations or when an in-person survey is not viable.
Using Twitter-Based Data for Sexual Violence Research: Scoping Review (Preprint)
Authors: Xue Jia , Zhang Bolun , Zhang Qiaoru , Hu Ran , Jiang Jielin , Liu Nian , Peng Yingdong , Li Ziqian , Logan Judith
Published: February 2023

BACKGROUND

Scholars have used data from in-person interviews, administrative systems, and surveys for sexual violence research. Using Twitter as a data source for examining the nature of sexual violence is a relatively new and underexplored area of study.

OBJECTIVE

We aimed to perform a scoping review of the current literature on using Twitter data for researching sexual violence, elaborate on the validity of the methods, and discuss the implications and limitations of existing studies.

METHODS

We performed a literature search in the following 6 databases: APA PsycInfo (Ovid), Scopus, PubMed, International Bibliography of Social Sciences (ProQuest), Criminal Justice Abstracts (EBSCO), and Communications Abstracts (EBSCO), in April 2022. The initial search identified 3759 articles that were imported into Covidence. Seven independent reviewers screened these articles following 2 steps: (1) title and abstract screening, and (2) full-text screening. The inclusion criteria were as follows: (1) empirical research, (2) focus on sexual violence, (3) analysis of Twitter data (ie, tweets or Twitter metadata), and (4) text in English. Finally, we selected 121 articles that met the inclusion criteria and coded these articles.

RESULTS

We coded and presented the 121 articles using Twitter-based data for sexual violence research. About 70% (89/121, 73.6%) of the articles were published in peer-reviewed journals after 2018. The reviewed articles collectively analyzed about 79.6 million tweets. The primary approaches to using Twitter as a data source were content text analysis (112/121, 92.5%) and sentiment analysis (31/121, 25.6%). Hashtags (103/121, 85.1%) were the most prominent metadata feature, followed by tweet time and date, retweets, replies, URLs, and geotags. More than a third of the articles (51/121, 42.1%) used the application programming interface to collect Twitter data. Data analyses included qualitative thematic analysis, machine learning (eg, sentiment analysis, supervised machine learning, unsupervised machine learning, and social network analysis), and quantitative analysis. Only 10.7% (13/121) of the studies discussed ethical considerations.

CONCLUSIONS

We described the current state of using Twitter data for sexual violence research, developed a new taxonomy describing Twitter as a data source, and evaluated the methodologies. Research recommendations include the following: development of methods for data collection and analysis, in-depth discussions about ethical norms, exploration of specific aspects of sexual violence on Twitter, examination of tweets in multiple languages, and decontextualization of Twitter data. This review demonstrates the potential of using Twitter data in sexual violence research.
Bone mineral density and other risk factors in children and adolescents with low-energy fractures of long bones
Authors: Umarov F.Х. , Matanov Z.М.
Published: February 2023

Background. There are an increasing number of children and adolescents with reduced age-related rate of bone mass accumulation, low bone mineral density (BMD) and low-energy fractures. This problem is widely discussed in the scientific literature. Purpose of the study was to assess the BMD in children and adolescents with low-energy fractures of long bones and to investigate some biochemical parameters of bone metabolism. Materials and methods. Body mass index (BMI), bone densitometry, levels of vitamin D, calcium, phosphorus and alkaline phosphatase in blood serum of 230 children and adolescents with low-energy fractures of long bones, aged 6 to 17 years, who underwent treatment due to the fractures were studied. Results. Fractures occurred predominantly in 41.3% of the humerus and 43% of the forearm bones. 20% of children and adolescents had abnormal BMI values. Low BMD values in 86 of 230 examinees were detected in the lumbar spine, of which only 66 (76.7%) had BMD abnormalities in the hip. In assessing vitamin D status, 19.3% of the girls and 9.2% of the boys had normal vitamin D values. A decrease in calcium level and an increase in alkaline phosphatase in blood serum were found. In terms of BMD and vitamin D status, the dependence of boys was statistically significant in the elementary and high school groups, while in girls it was only in the elementary school group. A direct link between low BMD and vitamin D has been established. Conclusions. Low BMD, vitamin D, impaired calcium-phosphorus metabolism and obesity in children and adolescents may be considered predictors of fracture occurrence.
Study on App Contents for Building a Daily Life Safety Information System at Home: Targeting Infants and Toddlers
Authors:   Residential Environment Institute Of Korea, Choi Jung min , Kim Yu na
Published: February 2023

This study aims to provide information for the development of an information system related to the daily life safety of infants and young children at home. An online survey was conducted on 500 women aged 20-49 across the country who had experience in child-rearing on their experiences and perceptions related to safety in the process of raising infants and toddlers, as well as their demands for a daily life safety information system. As a result, first, in Korea, a lot of information related to childcare safety is provided through the community bulletin board of Mom Cafe, but it is operated privately for men, showing difficulties in accessibility and limitations in reliability. Second, information related to daily life safety for children in online is mainly supplied by public institutions, but the content provided is common sense and has many overlapping contents, especially it is very difficult to find information targeting infants and toddlers in the home. Third, while the survey participants' demand for emergency medical information was high, the urgent need for improvement measures was improvement of the quantity and quality of content and comprehensive and customized content. Finally, as a result of subdividing the characteristics of the survey participants in order to provide content customized to consumers related to safety issues, they were divided into 'sensitive' and 'general', which are very sensitive to living safety. Among them, the safety-sensitive type showed more active demand and demand for participation in all evaluation items of hope for information system related to safety for infants and toddlers at home.
A Review about the Applicability of French Action Logement Services to a New Funding Source for National Housing and Urban Fund
Authors:   Residential Environment Institute Of Korea, Kim Jin
Published: February 2023

There has been a thin literature concerning NHUF (National Housing and Urban Fund), specifically how to extend its cash-inflow sources circulatable on a long-term basis. Two main funding sources of NHUF, Korea Treasury Bond and Housing Subscriptive Savings Account, are so vulnerable to the changes of economic cycles and have a fine limit to upgrade the amount. The purpose of this study is to review the French case of ALS (Action Logement Services) using the employers’ compulsory donation, named as PEEC (Participation des employeurs a l'effort de construction: Participation of Employers in the Construction Effort), and then examine its applicability to NHUF in Korea. In the PEEC, all the business entities which hire more than 50 employees must donate 0.45% of payrolls in the previous year to ALC. Applying the system only to 500 big firms in Korea can increase around 450 billion KRW each year thereby being very beneficial to securing a long-run funding source. Firms may raise complaints against the introduction of a new quasi-tax, thus the government must consider mitigation measures to blunt the firms’ burden, e.g. firms’ lending to NHUF and the immediate securitization of those loan assets in the capital market. An alternative collection idea is to add some more percentage to the registration fees for new buildings, e.g. 0.5% of building value. It is expected to generate more than half a trillion KRW each year.
A Study on Improvement Plans for a Local Financial Investment Project Evaluation System
Authors:   Residential Environment Institute Of Korea, Shim Hee cheol , Kim Jae hwan
Published: February 2023

This study aimed to summarize previous research on local financial investment reviews and the project evaluation method for rational investment decisions related appraising local financial investment projects. Measures were developed to quantify qualitative reviews, and new indicators were created. Lastly, academic and practical implications were considered, and a new evaluation system and sub-system for divisional investment projects were proposed based on these considerations. The results include a score table for each grade, with perfect scores set at 10 points for each element. A proposal for a new division was also made based on the classification of basic, intermediate, and optional investment projects. Taking the current division system into account, the proposal suggested the basic investment division, the intermediate investment first division, the intermediate investment second division, and the optional investment division. With this study, it is expected that investment screening can be conducted from a more objective and consistent standpoint, because it provides basic data for solving problems related to subjective screening standards, which have been seen as problematic.
Pengaruh Ekspor dan Impor terhadap Pertumbuhan Ekonomi di Provinsi Aceh
Authors: Muhammad Adnan  , Yulindawati  , Mifda Fernandi
Published: February 2023

Salah satu tolak ukur kemajuan suatu negara ditandai dengan meningkatnya pertumbuhan ekonomi, meningkatnya pertumbuhan ekonomi dihitung dari bertambahnya jumlah produksi barang atau jasa dalam perekonomian sehingga meningkatkan pendapatan perkapika penduduk di suatu negara. Pertumbuhan ekonomi dapat dicapai dengan spesialisasi dalam produksi barang dan jasa. Spesialisasi dapat terjadi jika ada pasar yang besar untuk menampung produksi, pasar ada jika suatu negara melakukan perdagangan internasional. Adapun pertumbuhan ekonomi Provinsi Aceh tahun 2020 sebesar -0,37% dengan total ekspor US$ 300.412.290 dan impor US$ 25.776.341, sedangkan pertumbuhan ekonomi tahun 2018 sebesar 4,14% dengan total ekspor US$ 250.735.059 dan impor US$ 29.690.002. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh ekspor dan impor terhadap pertumbuhan ekonomi di Provinsi Aceh. Penelitian ini menggunakan pendekatan kuantitatif. Data yang digunakan adalah jumlah ekspor, impor dan pertumbuhan ekonomi Provinsi Aceh dari tahun 1990-2020. Metode analisis data menggunakan Vector Error Correction Model (VECM). Hasil uji VECM dalam jangka panjang bahwa ekspor berpengaruh positif dan signifikan terhadap pertumbuhan ekonomi, sedangkan impor berpengaruh negatif dan signifikan terhadap pertumbuhan ekonomi. Hasil uji VECM dalam jangka pendek bahwa ekspor berpengaruh negatif dan tidak signifikan terhadap pertumbuhan ekonomi, sedangkan impor berpengaruh negatif dan signifikan terhadap pertumbuhan ekonomi, untuk meningkatkan pertumbuhan ekonomi dapat dilakukan dengan meningkatkan ekspor barang jadi dan impor bahan baku untuk keperluan industri yang tidak ditemukan di wilayah tersebut.