bluuebunny/crossref_metadata_2025 huggingface dataset:
The Algal Chloroplast as a Testbed for Synthetic Biology Designs Aimed at Radically Rewiring Plant Metabolism
Authors: Jackson Harry O. , Taunt Henry N. , Mordaka Pawel M. , Smith Alison G. , Purton Saul
Published: October 2021

Sustainable and economically viable support for an ever-increasing global population requires a paradigm shift in agricultural productivity, including the application of biotechnology to generate future crop plants. Current genetic engineering approaches aimed at enhancing the photosynthetic efficiency or composition of the harvested tissues involve relatively simple manipulations of endogenous metabolism. However, radical rewiring of central metabolism using new-to-nature pathways, so-called “synthetic metabolism”, may be needed to really bring about significant step changes. In many cases, this will require re-programming the metabolism of the chloroplast, or other plastids in non-green tissues, through a combination of chloroplast and nuclear engineering. However, current technologies for sophisticated chloroplast engineering (“transplastomics”) of plants are limited to just a handful of species. Moreover, the testing of metabolic rewiring in the chloroplast of plant models is often impractical given their obligate phototrophy, the extended time needed to create stable non-chimeric transplastomic lines, and the technical challenges associated with regeneration of whole plants. In contrast, the unicellular green alga, Chlamydomonas reinhardtii is a facultative heterotroph that allows for extensive modification of chloroplast function, including non-photosynthetic designs. Moreover, chloroplast engineering in C. reinhardtii is facile, with the ability to generate novel lines in a matter of weeks, and a well-defined molecular toolbox allows for rapid iterations of the “Design-Build-Test-Learn” (DBTL) cycle of modern synthetic biology approaches. The recent development of combinatorial DNA assembly pipelines for designing and building transgene clusters, simple methods for marker-free delivery of these clusters into the chloroplast genome, and the pre-existing wealth of knowledge regarding chloroplast gene expression and regulation in C. reinhardtii further adds to the versatility of transplastomics using this organism. Herein, we review the inherent advantages of the algal chloroplast as a simple and tractable testbed for metabolic engineering designs, which could then be implemented in higher plants.
Toward Integrated Multi-Omics Intervention: Rice Trait Improvement and Stress Management
Authors: Iqbal Zahra , Iqbal Mohammed Shariq , Khan M. Iqbal R. , Ansari Mohammad Israil
Published: October 2021

Rice (Oryza sativa) is an imperative staple crop for nearly half of the world’s population. Challenging environmental conditions encompassing abiotic and biotic stresses negatively impact the quality and yield of rice. To assure food supply for the unprecedented ever-growing world population, the improvement of rice as a crop is of utmost importance. In this era, “omics” techniques have been comprehensively utilized to decipher the regulatory mechanisms and cellular intricacies in rice. Advancements in omics technologies have provided a strong platform for the reliable exploration of genetic resources involved in rice trait development. Omics disciplines like genomics, transcriptomics, proteomics, and metabolomics have significantly contributed toward the achievement of desired improvements in rice under optimal and stressful environments. The present review recapitulates the basic and applied multi-omics technologies in providing new orchestration toward the improvement of rice desirable traits. The article also provides a catalog of current scenario of omics applications in comprehending this imperative crop in relation to yield enhancement and various environmental stresses. Further, the appropriate databases in the field of data science to analyze big data, and retrieve relevant informationvis-à-visrice trait improvement and stress management are described.
Arabidopsis thaliana PRR7 Provides Circadian Input to the CCA1 Promoter in Shoots but not Roots
Authors: Nimmo Hugh G. , Laird Janet
Published: October 2021

The core of the plant circadian clock involves multiple interlocking gene expression loops and post-translational controls along with inputs from light and metabolism. The complexity of the interactions is such that few specific functions can be ascribed to single components. In previous work, we reported differences in the operation of the clocks in Arabidopsis shoots and roots, including the effects of mutations of key clock components. Here, we have used luciferase imaging to study prr7 mutants expressing CCA1::LUC and GI::LUC markers. In mature shoots expressing CCA1::LUC, loss of PRR7 radically altered behaviour in light:dark cycles and caused loss of rhythmicity in constant light but had little effect on roots. In contrast, in mature plants expressing GI::LUC, loss of PRR7 had little effect in light:dark cycles but in constant light increased the circadian period in shoots and reduced it in roots. We conclude that most or all of the circadian input to the CCA1 promoter in shoots is mediated by PRR7 and that loss of PRR7 has organ-specific effects. The results emphasise the differences in operation of the shoot and root clocks, and the importance of studying clock mutants in both light:dark cycles and constant light.
Mapping and Characterization of a Wheat Stem Rust Resistance Gene in Durum Wheat “Kronos”
Authors: Li Hongna , Hua Lei , Rouse Matthew N. , Li Tianya , Pang Shuyong , Bai Shengsheng , Shen Tao , Luo Jing , Li Hongyu , Zhang Wenjun , Wang Xiaodong , Dubcovsky Jorge , Chen Shisheng
Published: October 2021

Wheat stem (or black) rust is one of the most devastating fungal diseases, threatening global wheat production. Identification, mapping, and deployment of effective resistance genes are critical to addressing this challenge. In this study, we mapped and characterized one stem rust resistance (Sr) gene from the tetraploid durum wheat variety Kronos (temporary designation SrKN). This gene was mapped on the long arm of chromosome 2B and confers resistance to multiple virulent Pgt races, such as TRTTF and BCCBC. Using a large mapping population (3,366 gametes), we mapped SrKN within a 0.29 cM region flanked by the sequenced-based markers pku4856F2R2 and pku4917F3R3, which corresponds to 5.6- and 7.2-Mb regions in the Svevo and Chinese Spring reference genomes, respectively. Both regions include a cluster of nucleotide binding leucine-repeat (NLR) genes that likely includes the candidate gene. An allelism test failed to detect recombination between SrKN and the previously mapped Sr9e gene. This result, together with the similar seedling resistance responses and resistance profiles, suggested that SrKN and Sr9e may represent the same gene. We introgressed SrKN into common wheat and developed completely linked markers to accelerate its deployment in the wheat breeding programs. SrKN can be a valuable component of transgenic cassettes or gene pyramids that includes multiple resistance genes to control this devastating disease.
Theanine Improves Salt Stress Tolerance via Modulating Redox Homeostasis in Tea Plants (Camellia sinensis L.)
Authors: Chen Ziping , Lin Shijia , Li Juan , Chen Tingting , Gu Quan , Yang Tianyuan , Zhang Zhaoliang
Published: October 2021

Theanine, a unique non-proteinogenic amino acid, is one of the most abundant secondary metabolites in tea. Its content largely determines green tea quality and price. However, its physiological roles in tea plants remain largely unknown. Here, we showed that salt stress significantly increased the accumulation of glutamate, glutamine, alanine, proline, and γ-aminobutyric acid, as well as theanine, in the new shoots of tea plants. We further found that salt stress induced the expression of theanine biosynthetic genes, including CsGOGATs, CsAlaDC, and CsTSI, suggested that salt stress induced theanine biosynthesis. Importantly, applying theanine to the new shoots significantly enhanced the salt stress tolerance. Similar effects were also found in a model plant Arabidopsis. Notably, exogenous theanine application increased the antioxidant activity of the shoots under salt stress, suggested by reduced the reactive oxygen species accumulation and lipid peroxidation, as well as by the increased SOD, CAT, and APX activities and expression of the corresponding genes. Finally, genetic evidence supported that catalase-mediated antioxidant scavenging pathway is required for theanine-induced salt stress tolerance. Taken together, this study suggested that salt stress induces theanine biosynthesize in tea plants to enhance the salt stress tolerance through a CAT-dependent redox homeostasis pathway.
To Score or Not to Score? A Simulation Study on the Performance of Test Scores, Plausible Values, and SEM, in Regression With Socio-Emotional Skill or Personality Scales as Predictors
Authors: Bhaktha Nivedita , Lechner Clemens M.
Published: October 2021

This article addresses a fundamental question in the study of socio-emotional skills, personality traits, and related constructs: “To score or not to score?” When researchers use test scores or scale scores (i.e., fallible point estimates of a skill or trait) as predictors in multiple regression, measurement error in these scores tends to attenuate regression coefficients for the skill and inflate those of the covariates. Unlike for cognitive assessments, it is not fully established how severe this bias can be in socio-emotional skill assessments, that is, how well test scores recover the true regression coefficients — compared with methods designed to account for measurement error: structural equation modeling (SEM) and plausible values (PV). The different types of scores considered in this study are standardized mean scores (SMS), regression factor scores (RFS), empirical Bayes modal (EBM) score, weighted maximum likelihood estimates (WLE), and expected a posteriori (EAP) estimates. We present a simulation study in which we compared these approaches under conditions typical of socio-emotional skill and personality assessments. We examined the performance of five types of test scores, PV, and SEM with regard to two outcomes: (1) percent bias in regression coefficient of the skill in predicting an outcome; and (2) percent bias in the regression coefficient of a covariate. We varied the number of items, factor loadings/item discriminations, sample size, and relative strength of the relationship of the skill with the outcome. Results revealed that whereas different types of test scores were highly correlated with each other, the ensuing bias in regression coefficients varied considerably. The magnitude of bias was highest for WLE with short scales of low reliability. Bias when using SMS or WLE test scores was sometimes large enough to lead to erroneous research conclusions with potentially adverse implications for policy and practice (up to 55% for the regression coefficient of the skill and 20% for that of the covariate). EAP, EBM, and RFS performed better, producing only small bias in some conditions. Additional analyses showed that the performance of test scores also depended on whether standardized or unstandardized scores were used. Only PV and SEM performed well in all scenarios and emerged as the clearly superior options. We recommend that researchers use SEM, and preferably PV, in studies on the (incremental) predictive power of socio-emotional skills.
Beyond the Distributed Practice Effect: Is Distributed Learning Also Effective for Learning With Non-repeated Text Materials?
Authors: Greving Carla Elisabeth , Richter Tobias
Published: October 2021

Distributed learning is often recommended as a general learning strategy, but previous research has established its benefits mainly for learning with repeated materials. In two experiments, we investigated distributed learning with complementary text materials. 77 (Experiment 1) and 130 (Experiment 2) seventh graders read two texts, massed vs. distributed, by 1 week (Experiment 1) or 15 min (Experiment 2). Learning outcomes were measured immediately and 1 week later and metacognitive judgments of learning were assessed. In Experiment 1, distributed learning was perceived as more difficult than massed learning. In both experiments, massed learning led to better outcomes immediately after learning but learning outcomes were lower after 1 week. No such decrease occurred for distributed learning, yielding similar outcomes for massed and distributed learning after 1 week. In sum, no benefits of distributed learning vs. massed learning were found, but distributed learning might lower the decrease in learning outcomes over time.
With a Hint of Sudachi: Food Plating Can Facilitate the Fondness of Food
Authors: Kokaji Nao , Nakatani Masashi
Published: October 2021

Among the senses of food, our subjective sense of taste is significantly influenced by our visual perception. In appetite science, previous research has reported that when we estimate quality in daily life, we rely considerably on visual information. This study focused on the multimodal mental imagery evoked by the visual information of food served on a plate and examined the effect of the peripheral visual information of garnish on the sensory impression of the main dish. A sensory evaluation experiment was conducted to evaluate the impressions of food photographs, and multivariate analysis was used to structure sensory values. It was found that the appearance of the garnish placed on the plates close to the main dish contributes to visual appetite stimulants. It is evident that color, moisture, and taste (sourness and spiciness) play a major role in the acceptability of food. To stimulate one’s appetite, it is important to make the main dish appear warm. These results can be used to modulate the eating experience and stimulate appetite. Applying these results to meals can improve the dining experience by superimposing visual information with augmented reality technology or by presenting real appropriate garnishes.
The Effect of VR Avatar Embodiment on Improving Attitudes and Closeness Toward Immigrants
Authors: Chen Vivian Hsueh Hua , Ibasco Gabrielle C. , Leow Vetra Jing Xuan , Lew Juline Yun Yee
Published: October 2021

Past research has discussed how the embodiment of an outgroup avatar in virtual reality (VR) can reduce intergroup bias. However, little is known about the mechanisms and boundary conditions that shape this effect. This study examines how the embodiment of both outgroup and ingroup VR avatars in different orders influences attitudes and perceived closeness toward a co-ethnic immigrant outgroup in Singapore. It also investigates the role of empathy and social identity orientation (SIO) in this relationship. An experiment with four avatar embodiment conditions (ingroup-then-outgroup, outgroup-then-ingroup, ingroup-only, and outgroup-only) was carried out with 171 participants from a public university in Singapore. Results showed that embodying an outgroup avatar alone, compared to embodying an ingroup avatar alone, significantly improves both attitudes and closeness toward an immigrant outgroup. The order of embodiment matters to an extent, suggesting the greater effectiveness of outgroup-first over ingroup-first embodiment in reducing bias. Empathy mediates the effect of all three outgroup embodiment conditions on improved attitudes and closeness toward immigrants. It was also found that the stronger one’s SIO is, the more effective embodiment is in improving perceived closeness with the outgroupviaempathy. Theoretical implications of these findings are discussed.
Stress at Work: Can the Spiritual Dimension Reduce It? An Approach From the Banking Sector
Authors: Robina-Ramírez Rafael , Medina-Merodio José Amelio , Estriegana Rosa , Sánchez-Oro Marcelo , Castro-Serrano José
Published: October 2021

Stress at work motivated by pressures and labour control can alter the behaviour of workers. Since the 2008 economic crisis, banking in Spain has suffered a series of massive lay-offs to adjust to the new market situation. This new financial restructuring has meant greater labour pressure to achieve the required results. Faced with this adversity, employees have experienced greater stress at work. This work analyses the effect of reinforcing employees’ spiritual dimension to transcend and correctly manage work pressure and stress at work. In so doing, 601 employees from 294 financial entities of five large IBEX banks participated in this pilot project. Through a participatory methodology based on a review of the literature, the study indicators have been delimited. The data obtained have been treated using the SEM-PLS method. The results propose the incorporation of a series of tools to reinforce values and transcendent employee behaviour.
The Hierarchy of Defense Mechanisms: Assessing Defensive Functioning With the Defense Mechanisms Rating Scales Q-Sort
Authors: Di Giuseppe Mariagrazia , Perry J. Christopher
Published: October 2021

The psychodynamic concept of defense mechanisms is nowadays considered by professionals with various theoretical orientations of great importance in the understanding of human development and psychological functioning. More than half century of empirical research has demonstrated the impact of defensive functioning in psychological well-being, personality organization and treatment process-outcome. Despite the availability of a large number of measures for their evaluation, only a few instruments assess the whole hierarchy of defenses, based on the Defense Mechanisms Rating Scales (DMRS), which arguably offers an observer-rated gold standard of assessment. The present article illustrates the theoretical and methodological background of the DMRS-Q, the Q-sort version of the DMRS for clinical use. Starting from the definition and function of the 30 defense mechanisms included in the hierarchy, we extracted 150 items that captured a full range of defensive manifestations according to the DMRS theory. The DMRS-Q set is described in this paper with reference to the DMRS manual. Directions are also provided for using the DMRS-Q online software for the free and unlimited coding of defense mechanisms. After each coding, the DMRS-Q software provides a report including qualitative and quantitative scores reflecting the individual’s defensive functioning. Qualitative scores are displayed as theDefensive Profile Narratives(DPN), while quantitative scores are reported as Overall Defensive Functioning (ODF), defensive categories, defense levels, and individual defense mechanisms. Syntax for the scoring is displayed in the results and a clinical vignette of a psychotherapy session coded with the DMRS-Q is provided. The DMRS-Q is an easy-to-use, free, computerized measure that can help clinicians in monitoring changes in defense mechanisms, addressing therapeutic intervention, fostering symptoms decreasing and therapeutic alliance. Moreover, the DMRS-Q might be a valid tool for teaching the hierarchy of defense mechanisms and increase the observer-rated assessment of this construct in several research fields.
The Clinical Relevance of Interdisciplinary Research on Affect Regulation in the Analytic Relationship
Authors: Altimir Carolina , Jiménez Juan Pablo
Published: October 2021

After more than a century of existence, theoretical development, research, and clinical practice within the psychoanalytic movement have consistently demonstrated that psychoanalysis is not a unitary and autonomous discipline. This has been evidenced by the various ways in which psychoanalytic thought and practice have been informed by and have established a dialogue—more or less fruitful—with related disciplines (neurosciences, developmental psychology, psychotherapy research, attachment theory and research, feminism, philosophy). This dialogue has contributed to a better understanding of the functioning of the human psyche, and therefore of the analytic process, informing clinical interventions. In turn, it has enriched research on psychoanalytic practice and process, underlining the fact that research in psychoanalysis is fundamentally about clinical practice. Since its origins, psychoanalysis has made explicit the work on the patient-analyst relationship as the terrain in which the analytic process unfolds. For its part, research in psychotherapy has demonstrated the relevance of the therapeutic relationship for the good development and outcome of any psychotherapeutic process. This supports the argument that research in clinical psychoanalysis should be research on the impact of the analyst interventions on the analyst-patient relationship. In this context, a central element of what happens in the analytic relationship refers to affect communication and therefore, affect regulation, which is manifested in the transferential and counter-transferential processes, as well as in the therapeutic bond. On the other hand, affective regulation is found at the crossroads of etiopathogenesis, complex personality models and psychopathology, allowing the understanding of human functioning and the staging of these configurations in the patient-analyst relationship. In this way, research on affective regulation in the analytic process is proposed as a path that exemplifies interdisciplinary research and scientific pluralism from which psychoanalysis enriches and progresses as a discipline. The case of a line of research on affective regulation in psychoanalytic psychotherapy is illustrated. The need to resort to other disciplines, as well as the translational value of our research and its clinical usefulness, is discussed.
Social Comparison on Social Media Increases Career Frustration: A Focus on the Mitigating Effect of Companionship
Authors: Fukubayashi Nao , Fuji Kei
Published: October 2021

Social media has become a platform for the daily exchange of information. Although some studies have explored the role and influence of social media on career development, few have examined how daily social media use impacts individuals’ perceptions and emotions regarding their careers. The present study examined this issue using two surveys. We predicted that social comparison would mediate the link between social media usage and its psychological impact. Moreover, we hypothesized that the impact would be mitigated by social interactions (companionship). Study 1 (a self-reported survey that included 309 Japanese employees) demonstrated that viewing other users’ positive posts about their careers could lead to career frustration through social comparison. Concurrently, this study revealed that daily casual interaction with others reduced career frustration. Study 2 was based on an analysis of 1,254 responses obtained from a 7-day experience sampling method survey. It revealed that viewing other people’s career-related posts was associated with upward, downward, and non-directional social comparison. In turn, upward social comparison evoked career frustration at both between- and within-person levels, while downward comparison decreased career frustration at a between-person level. Similar to Study 1, the results of Study 2 indicated that career frustration was mitigated by casual communication with others. Both studies provide evidence that (1) daily social media use affects one’s perception and feelings about their career through social comparison, and (2) career frustration evoked through virtual interactions with others is mitigated by casual interactions in a face-to-face setting.
Physical Activity and Mental Health Among Physicians in Tertiary Psychiatric Hospitals: A National Crosssectional Survey in China
Authors: Luo Jin , Liu Huanzhong , Liu Yuanli , Jiang Feng , Tang Yi-Lang
Published: October 2021

This study aimed to examine the level of mental health and its correlates, particularly physical activity (PA) frequency, among physicians in tertiary psychiatric hospitals. In a national crosssectional survey, 4,520 physicians nested in 41 tertiary psychiatric hospitals from 29 provinces completed the online questionnaire. Their mean age was 38.5 ± 8.6 years, and 41.86% of physicians were men. More than one-third (35.24%) of physicians reported no PA in the past month, and only 21.88% reported happiness. Only 55.15 and 58.10% of the physicians reported normal status of depression and anxiety, respectively. In the adjusted multivariable ordinal logistic regression, higher PA frequency was associated with depression, anxiety, and happiness, except those who reported PA almost every day. Programs that aim to increase PA may promote the mental health of physicians in tertiary psychiatric hospitals.
COVID-19, Telecommuting, and (Virtual) Sickness Presenteeism: Working From Home While Ill During a Pandemic
Authors: Ruhle Sascha Alexander , Schmoll René
Published: October 2021

This study explored (virtual) sickness presenteeism in the context of the COVID-19 pandemic. Using qualitative data from 505 members of the German working population, it investigates how working from home, which rapidly increased because of the COVID-19 outbreak, is perceived with regard to the pandemic. The study explored how this development affects the decision to show absence or presence in case of illness. More than 1,300 responses to different open-end questions by presenteeists and non-presenteeists were analyzed. The findings suggest that many previously identified reasons for deciding for or against presenteeism are still applicable. However, noteworthy differences with regard to both telecommuting and the pandemic occurred. Virtual sickness presenteeism seems to be strongly encouraged by the possibility to adjust working conditions at home. Additionally, COVID-19 has affected the perceptions of health at work. The study contributes to a more in-depth understanding of (virtual) sickness presenteeism during a global pandemic. Six propositions for future research are developed, and the importance of context for the consequences of virtual sickness presenteeism is discussed.
Using Heartfulness Meditation and Brainwave Entrainment to Improve Teenage Mental Wellbeing
Authors: Yadav Ghazal Suhani , Cidral-Filho Francisco José , Iyer Ranjani B.
Published: October 2021

Teenagers are highly susceptible to mental health issues and this problem has been exacerbated by the quarantine restrictions of COVID-19. This study evaluated the use of Heartfulness Meditation and Audio Brainwave Entrainment to help teenagers cope with mental health issues. It used 30-min Heartfulness meditation and 15-min brainwave entrainment sessions with binaural beats and isochronic tones three times a week for 4 weeks. Using a pretest-posttest methodology, participants were asked to complete a survey battery including the Pittsburgh Quality of Sleep Index, Perceived Stress Scale, Patient Health Question-9, Profile of Mood States, and Cambridge Brain Health assessment. Participants (n = 40) were divided into four experimental groups: the control group (n = 9), Audio Brainwave Entrainment group (n = 9), Heartfulness Meditation group (n = 10), and a combined group (n = 12), for a 4-week intervention. Data were analyzed with paired t-tests. The singular Audio Brainwave Entrainment group did not see statistically significant improvements, nor did any of the intervention groups for brain health (p > 0.05). This study, however, proved the efficacy of a 4-week Heartfulness Meditation program to regulate overall mood (p = 0.00132), stress levels (p = 0.0089), state depression (POMS; p = 0.0037), and anger (p = 0.002). Results also suggest adding Audio Brainwave Entrainment to Heartfulness Meditation may improve sleep quality (p = 0.0377) and stress levels (p = 0.00016).
The Effect of Fear of the COVID-19 on Depression Among Chinese Outbound Students Studying Online in China Amid the COVID-19 Pandemic Period: The Role of Resilience and Social Support
Authors: Chen Yikang , Liu Yifan , Zhang Yuxuan , Li Zheng , Zhou Tianshu
Published: October 2021

Objective:The present study focused on examining fear of the coronavirus disease 2019 (COVID-19) is correlated with depression and explored the potential role of resilience and social support on the association between fear of the COVID-19 (FoC) and depression among Chinese outbound students studying online in China amid the COVID-19 pandemic period.

Methods:A total of 476 Chinese outbound students from different universities worldwide, currently studyingviaonline mode in China, completed an online survey including measures on FoC, resilience, social support, and depression.

Results:(1) Fear of the COVID-19 was positively correlated with depression and negatively correlated with resilience and social support. Both resilience and social support were negatively correlated with depression. Social support showed a positive correlation with resilience. (2) The effect of FoC on depression mainly occurred through two paths: the mediating effect of resilience and the moderating effect of resilience. However, the moderating effect of social support on the association between FoC and depression was not sustained in this study.

Conclusion:This study indicated the mediating and moderating effects of resilience on the association between FoC and depression among Chinese outbound students studying online in China during the COVID-19 pandemic period. The current findings confirmed that resilience has significant implications in preventing negative mental states under the COVID-19 context among this particular group.
The Economic Effects of Direct and Indirect Employee Involvement: Evidence From Corporate Social Responsibility Reports of Chinese Listed Companies
Authors: Jiang Yongzhong , He Xixi , Zhu Yutao , Wu Guosong , Gao Xinzhi
Published: October 2021

Employee direct involvement and indirect involvement have been identified as essential forms of an enterprise’s democratic management in the digital economy. Research on the complementary effects of direct and indirect involvement is still in a blank state in China, which limits the external validity and accumulation of employee participation theory. The present study aimed to investigate the complementary effects of employee direct involvement and indirect involvement on the firm’s financial performance. Although previous research suggests that the influence of employee direct or indirect involvement on corporate financial performance has been examined separately, it is unclear whether the association between employee direct involvement and indirect involvement is complementary or conflictual. Based on strategic human resource management theory, we semantically encode 2,680 corporate social responsibility reports and the annual reports of 268 state-owned listed enterprises published from 2014 to 2018 via content analysis method, and the economic effects of employee direct involvement and indirect involvement were concurrently measured. We use configuration theory to explore the complementary effects between employee direct involvement and indirect involvement. Our results reveal that (1) employee involvement in Chinese enterprises was unbalanced, (2) both employee direct involvement and indirect involvement were positively related to enterprise’s financial performance, and (3) there is a complementary effect between the two forms of employee involvement. Theoretical and practical implications of these findings are discussed.
Internet Gaming Disorder, Risky Online Behaviour, and Mental Health in Hong Kong Adolescents: The Beneficial Role of Psychological Resilience
Authors: Tsui Yvonne Yin-yau , Cheng Cecilia
Published: October 2021

In the present cyber age, Internet gaming disorder (IGD) and risky online behaviour are prevalent, and adolescents are especially vulnerable to such emergent problems. Few studies have explored the protective factors that mitigate harm caused by IGD and various common risky online behaviours. This study examined the prevalence of IGD and risky online behaviour, their hypothesised associations with depressive symptoms, and the beneficial role of psychological resilience as an underlying psychological mechanism. The participants included 1,099 Chinese junior secondary school students (33% boys, mean age = 13.5 years, age range = 10–17 years) who completed a battery of validated self-report questionnaires at their schools. The results revealed that 4% of the participants were at high risk of IGD and 6% were at an overall risk level of IGD. Depressive symptoms were positively associated with IGD and risky online behaviour, and psychological resilience mediated both of these associations. These results imply that clinicians and teachers should incorporate psychological resilience training into intervention approaches to mitigate IGD and risky online behaviour.
GDP Forecasting: Machine Learning, Linear or Autoregression?
Authors: Maccarrone Giovanni , Morelli Giacomo , Spadaccini Sara
Published: October 2021

This paper compares the predictive power of different models to forecast the real U.S. GDP. Using quarterly data from 1976 to 2020, we find that the machine learning K-Nearest Neighbour (KNN) model captures the self-predictive ability of the U.S. GDP and performs better than traditional time series analysis. We explore the inclusion of predictors such as the yield curve, its latent factors, and a set of macroeconomic variables in order to increase the level of forecasting accuracy. The predictions result to be improved only when considering long forecast horizons. The use of machine learning algorithm provides additional guidance for data-driven decision making.
Kinematic-Based Classification of Social Gestures and Grasping by Humans and Machine Learning Techniques
Authors: Hemeren Paul , Veto Peter , Thill Serge , Li Cai , Sun Jiong
Published: October 2021

The affective motion of humans conveys messages that other humans perceive and understand without conventional linguistic processing. This ability to classify human movement into meaningful gestures or segments plays also a critical role in creating social interaction between humans and robots. In the research presented here, grasping and social gesture recognition by humans and four machine learning techniques (k-Nearest Neighbor, Locality-Sensitive Hashing Forest, Random Forest and Support Vector Machine) is assessed by using human classification data as a reference for evaluating the classification performance of machine learning techniques for thirty hand/arm gestures. The gestures are rated according to the extent of grasping motion on one task and the extent to which the same gestures are perceived as social according to another task. The results indicate that humans clearly rate differently according to the two different tasks. The machine learning techniques provide a similar classification of the actions according to grasping kinematics and social quality. Furthermore, there is a strong association between gesture kinematics and judgments of grasping and the social quality of the hand/arm gestures. Our results support previous research on intention-from-movement understanding that demonstrates the reliance on kinematic information for perceiving the social aspects and intentions in different grasping actions as well as communicative point-light actions.
Anatomy of Orion Molecular Clouds—The Astrochemistry Perspective/Approach
Authors: Sahu Dipen , Liu Sheng-Yuan , Liu Tie
Published: October 2021

The Orion molecular cloud (OMC) complex is the nearest and perhaps the best-studied giant molecular cloud complex within which low-mass and massive star formation occur. A variety of molecular species, from diatomic molecules to complex organic molecules (COMs), have been observed in the OMC regions. Different chemical species are found at different scales—from giant molecular clouds at parsec scales to cloud cores around young stellar objects at hundreds of au scales, and they act as tracers of different physical and chemical conditions of the sources. The OMC, therefore, is an ideal laboratory for studying astrochemistry over a broad spectrum of molecular cloud structures and masses. In this review, we discuss the usage of astrochemistry/molecular tracers and (sub) millimeter observations to understand the physical and chemical conditions of large-scale molecular clouds, filaments, and clumps down to cores and protostars in the OMC complex as a demonstration case.
The Occurrence and Prevalence of Time Domain Structures in the Kelvin-Helmholtz Instability at Different Positions Along the Earth’s Magnetospheric Flanks
Authors: Wilder F. D. , Ergun R. E. , Gove D. , Eriksson S. , Hansel P. , Ahmadi N. , Malaspina D. M. , Burch J. L. , Torbert R. B. , Strangeway R. J. , Giles B. L.
Published: October 2021

The Kelvin-Helmholtz instability (KHI) is thought to be an important driver for mass, momentum, and energy transfer between the solar wind and magnetosphere. This can occur through global-scale “viscous-like” interactions, as well as through local kinetic processes such as magnetic reconnection and turbulence. An important aspect of these kinetic processes for the dynamics of particles is the electric field parallel to the background magnetic field. Parallel electric field structures that can occur in the KHI include the reconnection electric field of high guide field reconnection, large amplitude ion acoustic waves, as well as time domain structures (TDS) such as double layers and electrostatic solitary waves. In this study, we present a survey of parallel electric field structures observed during three Kelvin Helmholtz events observed by NASA’s Magnetospheric Multiscale (MMS), each at different positions along the magnetosphere’s dusk flank. Using data from MMS’s on-board solitary wave detector (SWD) algorithm, we statistically investigate the occurrence of TDS within the KHI events. We find that early in the KHI development, TDS typically occur in regions with strong field-aligned currents (FACs) on the magnetospheric side of the vortices. Further down the flanks, as the vortices become more rolled up, the prevalence of large electric currents decreases, as well as the prevalence of SWDs. These results suggest that as the instability develops and vortices grow in size along the flanks, kinetic-scale activity becomes less prevalent.
Stormtime Energetics: Energy Transport Across the Magnetopause in a Global MHD Simulation
Authors: Brenner Austin , Pulkkinen Tuija I. , Al Shidi Qusai , Toth Gabor
Published: October 2021

Coupling between the solar wind and magnetosphere can be expressed in terms of energy transfer through the separating boundary known as the magnetopause. Geospace simulation is performed using the Space Weather Modeling Framework (SWMF) of a multi-ICME impact event on February 18–20, 2014 in order to study the energy transfer through the magnetopause during storm conditions. The magnetopause boundary is identified using a modified plasma β and fully closed field line criteria to a downstream distance of −20Re. Observations from Geotail, Themis, and Cluster are used as well as the Shue 1998 model to verify the simulation field data results and magnetopause boundary location. Once the boundary is identified, energy transfer is calculated in terms of total energy flux K, Poynting flux S, and hydrodynamic flux H. Surface motion effects are considered and the regional distribution of energy transfer on the magnetopause surface is explored in terms of dayside X>0, flank X<0, and tail cross section X=Xmin regions. It is found that total integrated energy flux over the boundary is nearly balanced between injection and escape, and flank contributions dominate the Poynting flux injection. Poynting flux dominates net energy input, while hydrodynamic flux dominates energy output. Surface fluctuations contribute significantly to net energy transfer and comparison with the Shue model reveals varying levels of cylindrical asymmetry in the magnetopause flank throughout the event. Finally existing energy coupling proxies such as the Akasofu ϵ parameter and Newell coupling function are compared with the energy transfer results.
Clopidogrel Loading Dose 300 vs. 600 mg in Patients Undergoing One-Stop Hybrid Coronary Revascularization: A Prospective Single-Center Randomized Pilot Study
Authors: Guo Yulin , Li Dongjie , Gao Yingdi , Zhao Jing , An Xiangguang , Liu Yan , Gu Song , Zhang Xitao , Gao Jie , Su Pixiong
Published: October 2021

Background: The optimal loading dose of clopidogrel in one-stop hybrid coronary revascularization (HCR) remains an “evidence-free” zone. This study aimed to compare the major bleeding and ischemic thrombotic events between different clopidogrel loading doses (300 vs. 600 mg) in one-stop HCR.

Methods: In this prospective, single-center, randomized, and parallel pilot study, 100 patients receiving one-stop HCR were randomly assigned to the clopidogrel loading dose 300-mg group or 600-mg group in a 1:1 ratio. Major bleeding events and composite in-hospital ischemic thrombotic and adverse complications were evaluated after the procedure.

Results: The results showed that postoperative mean chest drainage of the first 4 days and total drainage were comparable between the two groups. No differences were found in Bleeding Academic Research Consortium (BARC) coronary artery bypass grafting (CABG) related bleeding (4 vs. 2%, P = 1), PLATelet inhibition and patient Outcomes (PLATO) life-threatening bleeding (20 vs. 26%, P = 0.48), and PLATO major bleeding (70 vs. 76%, P = 0.5) in the two groups. The composite ischemic thrombotic and adverse events were also similar.

Conclusions: In patients receiving one-stop HCR, clopidogrel 600 mg loading dose did not increase major bleeding events compared with 300 mg. More sufficient data is necessary to evaluate the potential benefits of 600 mg loading dose in one-stop HCR.
Development of the SciRAP Approach for Evaluating the Reliability and Relevance of in vitro Toxicity Data
Authors: Roth Nicolas , Zilliacus Johanna , Beronius Anna
Published: October 2021

Efficient and successful integration of data generated from non-animal test methods must rely on reliable and relevant data. It is important therefore to develop tools and criteria that facilitate scientifically sound, structured, and transparent evaluation of reliability and relevance of in vitro toxicity data to efficiently inform regulatory hazard and risk assessment. The Science in Risk Assessment and Policy (SciRAP) initiative aims to promote such overarching goals. We present the work to develop and refine the SciRAP tool for evaluation of reliability and relevance of in vitro studies for incorporation on the SciRAP web-based platform (www.scirap.org). In the SciRAP approach, reliability evaluation is based on criteria for reporting quality and methodological quality, and is explicitly separated from relevance evaluation. The SciRAP in vitro tool (version 1.0) was tested and evaluated during an expert test round (April 2019-September 2020) on three in vitro studies by thirty-one experts from regulatory authorities, industry and academia from different geographical areas and with various degree of experience in in vitro research and/or human health risk assessment. In addition, the experts answered an online survey to collect their feedback about the general features and desired characteristics of the tool for further refinement. The SciRAP in vitro tool (version 2.0) was revised based on the outcome of the expert test round (study evaluation and online survey) and consists of 24 criteria for evaluating “reporting quality” (reliability), 16 criteria for “methodological quality” (reliability), and 4 items for evaluating relevance of in vitro studies. Participants were generally positive about the adequacy, flexibility, and user-friendliness of the tool. The expert test round outlined the need to (i) revise the formulation of certain criteria; (ii) provide new or revised accompanying guidance for reporting quality and methodological quality criteria in the “test compounds and controls,” “test system,” and “data collection and analysis” domains; and (iii) provide revised guidance for relevance items, as general measures to reduce inter-expert variability. The SciRAP in vitro tool allows for a structured and transparent evaluation of in vitro studies for use in regulatory hazard and risk assessment of chemicals.
Perspectives for Buck Kids in Dairy Goat Farming
Authors: Meijer Ellen , Goerlich Vivian C. , Brom René van den , Giersberg Mona F. , Arndt Saskia S. , Rodenburg T. Bas
Published: October 2021

To start milk production, dairy goats need to give birth at least once. While most female kids are reared to become the next generation of dairy goats, only a small proportion of male kids (buck kids) are reared with reproduction aims. The market for buck kid meat, especially within Northern European countries, is currently relatively small compared to the number of bucks born. Therefore, the purposes for buck kids are limited and a substantial proportion of buck kid meat is used for pet food. Due to the limited economic value of buck kids, farmers are faced with a dilemma. Although raising bucks costs more money than it yields, the birth of kids is a prerequisite for production of milk and should be seen as an investment for business-wise healthy dairy goat farming. In that perspective, dairy goat farmers have an ethical responsibility toward buck kids, as well. In this paper, we compare various scenarios of dealing with the issue of surplus male animals. We provide recommendations for the rearing of buck kids based on the sector‘s experience and current practice in the Netherlands. Reducing the number of surplus (male) offspring, e.g., by an optimized prolonged lactation management and/or by artificial insemination with sex-sorted semen, could alleviate the issue of low value buck kids. Killing surplus animals before or directly after birth, on the other hand, is met with increasing societal scrutiny. Initiatives to propagate a market for buck kid meat for human consumption are important to enable a suitable and sustainable production system. To maintain the health and welfare of goat kids, amongst other factors, sufficient and good quality colostrum, milk, and an appropriate diet as they grow older, needs to be provided. One option to assure the safeguarding of health and welfare of all goat kids are quality assurance schemes for milk production. These schemes make dairy farmers accountable for the health and welfare of all kids in the rearing period, including the provision of colostrum and adequate care for newborn buck kids. We conclude that the combination of reducing the number of surplus kids, increasing the demand for goat products, and quality assurance schemes that may help to safeguard the welfare of buck kids.
The Animal Welfare Science of Working Dogs: Current Perspectives on Recent Advances and Future Directions
Authors: Cobb Mia L. , Otto Cynthia M. , Fine Aubrey H.
Published: October 2021

Working dogs are prevalent throughout our societies, assisting people in diverse contexts, from explosives detection and livestock herding, to therapy partners. Our scientific exploration and understanding of animal welfare have grown dramatically over the last decade. As community attitudes toward the use of animals continue to change, applying this new knowledge of welfare to improve the everyday lives of working dogs will underpin the sustainability of working with dogs in these roles. The aim of this report was to consider the scientific studies of working dogs from the last decade (2011–2021) in relation to modern ethics, human interaction, and the five domains of animal welfare: nutrition, environment, behavioral interaction, physical health, and mental state. Using this framework, we were able to analyze the concept and contribution of working dog welfare science. Noting some key advances across the full working dog life cycle, we identify future directions and opportunities for interdisciplinary research to optimize dog welfare. Prioritizing animal welfare in research and practice will be critical to assure the ongoing relationship between dogs and people as co-workers.