bluuebunny/crossref_metadata_2025 huggingface dataset:
Cell-free tumour DNA analysis detects copy number alterations in gastro-oesophageal cancer patients
Authors: Wallander Karin , Eisfeldt Jesper , Lindblad Mats , Nilsson Daniel , Billiau Kenny , Foroughi Hassan , Nordenskjöld Magnus , Liedén Agne , Tham Emma
Published: February 2021

Background

Analysis of cell-free tumour DNA, a liquid biopsy, is a promising biomarker for cancer. We have performed a proof-of principle study to test the applicability in the clinical setting, analysing copy number alterations (CNAs) in plasma and tumour tissue from 44 patients with gastro-oesophageal cancer.

Methods

DNA was isolated from blood plasma and a tissue sample from each patient. Array-CGH was applied to the tissue DNA. The cell-free plasma DNA was sequenced by low-coverage whole-genome sequencing using a clinical pipeline for non-invasive prenatal testing. WISECONDOR and ichorCNA, two bioinformatic tools, were used to process the output data and were compared to each other.

Results

Cancer-associated CNAs could be seen in 59% (26/44) of the tissue biopsies. In the plasma samples, a targeted approach analysing 61 regions of special interest in gastro-oesophageal cancer detected cancer-associated CNAs with a z-score >5 in 11 patients. Broadening the analysis to a whole-genome view, 17/44 patients (39%) had cancer-associated CNAs using WISECONDOR and 13 (30%) using ichorCNA. Of the 26 patients with tissue-verified cancer-associated CNAs, 14 (54%) had corresponding CNAs in plasma. Potentially clinically actionable amplifications overlapping the genesVEGFA,EGFRandFGFR2were detected in the plasma from three patients.

Conclusions

We conclude that low-coverage whole-genome sequencing without prior knowledge of the tumour alterations could become a useful tool for cell-free tumour DNA analysis of total CNAs in plasma from patients with gastro-oesophageal cancer.
Niche construction mediates climate effects on recovery of tundra heathlands after extreme event
Authors: González Victoria T. , Lindgård Bente , Reiersen Rigmor , Hagen Snorre B. , Bråthen Kari Anne
Published: February 2021

Climate change is expected to increase the frequency and intensity of extreme events in northern ecosystems. The outcome of these events across the landscape, might be mediated by species effects, such as niche construction, with likely consequences on vegetation resilience. To test this hypothesis, we simulated an extreme event by removing aboveground vegetation in tundra heathlands dominated by the allelopathic dwarf shrub Empetrum nigrum, a strong niche constructor. We tested the hypothesis under different climate regimes along a 200-km long gradient from oceanic to continental climate in Northern Norway. We studied the vegetation recovery process over ten years along the climatic gradient. The recovery of E. nigrum and subordinate species was low and flattened out after five years at all locations along the climatic gradient, causing low vegetation cover at the end of the study in extreme event plots. Natural seed recruitment was low at all sites, however, the addition of seeds from faster growing species did not promote vegetation recovery. A soil bioassay from 8 years after the vegetation was removed, suggested the allelopathic effect of E. nigrum was still present in the soil environment. Our results provide evidence of how a common niche constructor species can dramatically affect ecosystem recovery along a climatic gradient after extreme events in habitats where it is dominant. By its extremely slow regrowth and it preventing establishment of faster growing species, this study increases our knowledge on the possible outcomes when extreme events harm niche constructors in the tundra.
Disposal practices of expired and unused medications among households in Mwanza, Tanzania
Authors: Marwa Karol Julius , Mcharo Glory , Mwita Stanley , Katabalo Deogratias , Ruganuza Deodatus , Kapesa Anthony
Published: February 2021

Background

The community practice towards disposal of expired and unused medications in spite of its adverse impact have been widely neglected in many developing countries. The available guidelines in Tanzania focus on the disposal of expired medications and cosmetics in hospitals and community pharmacies only.

Aim

The aim of this study was to assess the disposal practice of expired and unused medications at household level in Mwanza city, north-western Tanzania.

Methodology

The household based cross-sectional study was conducted among 359 randomly selected household members. Semi-structured questionnaires were used for interview during data collection and while STATA®version 13 was used for analysis.

Results

Out 359 households visited, 252 (70.19%) had medications kept in their houses at the time of data collection. Among them, 10 (4.0%) households had kept medications at their houses because they were still continuing with treatment while 242 (96.0%) kept unused medications which were supposed to be discarded. The main reason for keeping unused or expired medications at home was uncompleted course of treatment (199 (82.20%) after feeling that they had recovered from illness. The main reason for discarding medications were recovering from illness (141(48.7%) and expiry (136 (46.9%). The major discarding practices for medications were disposing into domestic trashes (219 (75.5%) and pit latrines (45 (15.5%). Majority of respondents (273 (76%) were aware that improper disposal of expired medications are detrimental to human health and environment in general.

Conclusion

Improper disposal of unused and expired medications at household level was a common practice in the study area. Tailor-made interventions by the Food and Drugs Authority (FDA) and other national as well as local stake holders are urgently needed to address the situation.
Sustained benefits of cognitive training in children with inattention, three-year follow-up
Authors: Jurigova Barbora G. , Gerdes Molly R. , Anguera Joaquin A. , Marco Elysa J.
Published: February 2021

The goal of this study was to test for long-term benefits three years after the completion of a cognitive training intervention (Project: EVO™) in a subset of children with Sensory Processing Dysfunction (SPD). Our initial findings revealed that children with SPD who also met research criteria for Attention Deficit Hyperactivity Disorder (SPD+IA) showed a significant decrease in parent-observed inattentive behaviors, which remained stable in a nine-month follow-up assessment. Forty nine caregivers of participants who completed the Project: EVO™ training were contacted to be included in this follow up study. Each was emailed an invitation to complete the Vanderbilt ADHD Diagnostic Parent Rating Scale, which yielded a completion rate of 39/49 (80%). A Generalized Estimating Equations analysis was used to assess changes in symptoms over time, specifically to determine whether the initial improvements were retained. The SPD+IA cohort continued to show sustained benefits on their parent-reported scores of inattention, with 54% of SPD+IA individuals no longer meeting criteria for ADHD three years following intervention. These findings provide initial insights into the potential long-term benefits of a digital health intervention for children with attention-based issues.
Explaining mobile government social media continuance from the valence perspective: A SEM-NN approach
Authors: Peng Yubo , Wang LingWu , Yang Shuiqing
Published: February 2021

Different from many previous studies explain mobile social media usage from a technical-center perspective, the present study investigates the factors that influence citizens’ mobile government social media (GSM) continuance based on the valence framework. The research model was calculated by using data collected from 509 citizens who are the mobile GSM users in China. A structural equation modeling (SEM)-neural network (NN) method was employed to test the research model. The results of SEM indicated that the positive utilities included social value and hedonic value positively affect mobile GSM continuance, while the negative utility reflected by self-censorship negative affect mobile GSM continuance. This is further supported by the results of the neural network model analysis which indicated that hedonic value is more influencing predictor of continuous usage of mobile GSM, following by social value and self-censorship.
Prevalence and associated factors of impaired renal function and albuminuria among adult patients admitted to a hospital in Northeast Ethiopia
Authors: Fiseha Temesgen , Ahmed Ermiyas , Chalie Semagn , Gebreweld Angesom
Published: February 2021

Background

Chronic kidney disease (CKD) is increasingly common in hospitalized patients and is associated with increased risk for in-hospital morbidity and mortality. However, data regarding the prevalence of CKD in the African hospitalized patient population are limited. We therefore examined the prevalence and associated factors of impaired renal function and albuminuria among adult patients admitted to the internal medicine wards of a hospital in Northeast Ethiopia.

Methods

A cross-sectional study was conducted from January 1 to April 30, 2020 at the inpatient settings of Dessie referral hospital. Data on demographics and medical history were obtained, and serum creatinine and albuminuria were analyzed. Estimated glomerular filtration rate (eGFR) was calculated using the Modification of Diet in Renal Disease (MDRD) equation. CKD was defined as impaired eGFR (<60 ml/min/1.73m2) and/or albuminuria. Univariate and multivariable analysis were conducted to determine factors associated with impaired eGFR and albuminuria.

Results

A total of 369 patients were included in this study. The prevalence of impaired eGFR was 19.0% (95%CI: 15.2%–23.2%) and albuminuria was 30.9% (95%CI: 26.3%–35.7%). Overall, 33.9% (95%CI: 29.2%–38.9%) of the patients had some degree of CKD, but only 21.6% (95%CI: 15.1%–29.4%) were aware of their renal disease. In multivariable analysis, older age, a family history of kidney disease, diabetes, hypertension and HIV were independently associated with both impaired eGFR and albuminuria while male gender was independently associated with only albuminuria.

Conclusions

CKD is common in adult patients admitted to the internal medicine wards, but only few patients are aware of their condition. These findings highlight the need for feasible approaches to timely identify kidney disease and raise awareness on the importance of detection and early intervention in the inpatient settings.
Use of advanced PET-volume metrics predicts risk of local recurrence and overall survival in anal cancer
Authors: Susko Matthew S. , Lazar Ann A. , Wang Chia-Ching Jackie , Van Loon Katherine , Feng Mary , Hope Tom A. , Behr Spencer , Anwar Mekhail
Published: February 2021

Objective

Anal cancer is an uncommon malignancy with the primary treatment for localized disease being concurrent radiation and chemotherapy. Pre-treatment PET/CT is useful for target delineation, with minimal exploration of its use in prognostication. In the post-treatment setting there is growing evidence for advanced PET metrics in assessment of treatment response, and early identification of recurrence essential for successful salvage, however this data is limited to small series.

Methods

Patient with non-metastatic anal cancer from a single institution were retrospectively reviewed for receipt of pre- and post-treatment PET/CTs. PET data was co-registered with radiation therapy planning CT scans for precise longitudinal assessment of advanced PET metrics including SUVmax, metabolic tumor volume (MTV), and total lesion glycolysis (TLG), for assessment with treatment outcomes. Treatment outcomes included local recurrence (LR), progression free survival (PFS), and overall survival (OS), as defined from the completed radiation therapy to the time of the event. Cox proportional hazard modeling with inverse probability weighting (IPW) using the propensity score based on age, BMI, T-stage, and radiation therapy dose were utilized for assessment of these metrics.

Results

From 2008 to 2017 there were 72 patients who had pre-treatment PET/CT, 61 (85%) had a single follow up PET/CT, and 35 (49%) had two follow up PET/CTs. The median clinical follow-up time was 25 months (IQR: 13–52) with a median imaging follow up time of 16 months (IQR: 7–29). On pre-treatment PET/CT higher MTV2.5 and TLG were significantly associated with higher risk of local recurrence (HR 1.11, 95% CI: 1.06–1.16, p<0.001; and HR 1.12, 95% CI: 1.05–1.19, p<0.001), and worse PFS (HR 1.09, 95% CI: 1.04–1.13, p<0.001; and HR 1.09, 95% CI: 1.03–1.12, p = 0.003) and OS (HR 1.09, 95% CI: 1.04–1.16, p = 0.001; and HR 1.11, 95% CI: 1.04–1.20, p = 0.004). IPW-adjusted pre-treatment PET/CT showed higher MTV2.5 (HR 1.09, 95% CI: 1.02–1.17, p = 0.012) and TLG (HR 1.10, 95% CI: 1.00–1.20, p = 0.048) were significantly associated with worse PFS, and post-treatment MTV2.5 was borderline significant (HR 1.16, 95% CI: 1.00–1.35, p = 0.052).

Conclusion

Advanced PET metrics, including higher MTV2.5 and TLG, in the pre-treatment and post-treatment setting are significantly associated with elevated rates of local recurrence, and worse PFS and OS. This adds to the growing body of literature that PET/CT for patient with ASCC should be considered for prognostication, and additionally is a useful tool for consideration of early salvage or clinical trial of adjuvant therapies.
Experiences, distress and burden among neurologists in Norway during the COVID-19 pandemic
Authors: Kristoffersen Espen Saxhaug , Winsvold Bendik Slagsvold , Sandset Else Charlotte , Storstein Anette Margrethe , Faiz Kashif Waqar
Published: February 2021

Background

The ongoing COVID-19 pandemic has caused rapid changes in the healthcare system. Workforce reorganization, reduced standard of care and a lack of personal protection equipment (PPE) for health care workers were among the concerns raised in the first wave of the pandemic. Our aim was to explore the experiences, distress and burden among Norwegian neurologists during the first weeks of the pandemic.

Methods

Hospital-based neurologists in Norway (n = 400) were invited to a web-based survey in April 2020. The study focused on patient management, organizational changes and personal stress during the first weeks of the pandemic lockdown. Work-home interface stress was assessed by the Cooper Job Stress Questionnaire.

Results

In total, 135 neurologists participated. Seventy-three% experienced a change in their personal work situation, and 67% examined patients with suspected COVID-19 infection and neurological disease. Changed access to resources, and the perception that medical follow-up was unsatisfactory, were associated with a high degree of burden and stress. Neurologists were also worried about the potential lack of PPE and the fear of spreading SARS CoV-2 to close family members. The mean score of work-home interface stress was 2.8 with no significant differences between gender or specialist status. Reduced standard of care was reported for all neurological conditions, and in particular for non-emergency treatments.

Conclusion

The vast majority of neurologists in Norway experienced a change in their personal work situation during the first phase of the pandemic. The fear of becoming infected and ill was not a major contributor to burden and stress.
N-Glycans and sulfated glycosaminoglycans contribute to the action of diverse Tc toxins on mammalian cells
Authors: Song Nan , Chen Lihong , Ren Xingmei , Waterfield Nicholas R. , Yang Jian , Yang Guowei
Published: February 2021

Tc toxin is an exotoxin composed of three subunits named TcA, TcB and TcC. Structural analysis revealed that TcA can form homopentamer that mediates the cellular recognition and delivery processes, thus contributing to the host tropism of Tc toxin.N-glycans and heparan sulfates have been shown to act as receptors for several Tc toxins. Here, we performed two independent genome-wide CRISPR-Cas9 screens, and have validated glycans and sulfated glycosaminoglycans (sGAGs) as Tc toxin receptors also for previously uncharacterized Tc toxins. We found that TcdA1 form Photorhabdus luminescens W14 (TcdA1W14) can recognizeN-glycansviathe RBD-D domain, corroborating previous findings. Knockout ofN-glycan processing enzymes specifically blocks the intoxication of TcdA1W14-assembled Tc toxin. On the other hand, our results showed that sGAG biosynthesis pathway is involved in the cell surface binding of TcdA2TT01(TcdA2 fromP.luminescensTT01). Competition assays and biolayer interferometry demonstrated that the sulfation group in sGAGs is required for the binding of TcdA2TT01. Finally, based on the conserved domains of representative TcA proteins, we have identified 1,189 putative TcAs from 1,039 bacterial genomes. These TcAs are categorized into five subfamilies. Each subfamily shows a good correlation with both genetic organization of the TcA protein(s) and taxonomic origin of the genomes, suggesting these subfamilies may utilize different mechanisms for cellular recognition. Taken together, our results support the previously described two different binding modalities of Tc toxins, leading to unique host targeting properties. We also present the bioinformatics data and receptor screening strategies for TcA proteins, provide new insights into understanding host specificity and biomedical applications of Tc toxins.
Peindre à Rouen au XVIe siècle: quelques résultats
Authors: Elsig Frédéric
Published: February 2021

L’article présente quelques résultats du programme Peindre en France à la Renaissance, débuté à l’Université de Genève en 2010, et en particulier du sixième volume de la série: Peindre à Rouen au XVIe siècle. En vue de comprendre le contexte de la formation du sculpteur Jean de Rouen, il se focalise sur la production du premier tiers du XVIe siècle à travers deux phénomènes: d’une part, la tradition locale, illustrée par la famille Le Vieil; d’autre part, le courant néerlandais, représenté par Arnoult de Nimègue.
Identification of Multi-Faults in GNSS Signals using RSIVIA under Dual Constellation
Authors: Liu Shuchen , Gehrt Jan-Jöran , Abel Dirk , Zweigel René
Published: February 2021

This publication presents the development of integrity monitoring and fault detection and exclusion (FDE) of pseudorange measurements, which are used to aid a tightly-coupled navigation filter. This filter is based on an inertial measurement unit (IMU) and is aided by signals of global navigation satellite system (GNSS). Particularly, the GNSS signals include global positioning system (GPS) and Galileo. By using GNSS signals, navigation systems suffer from signal interferences resulting in large pseudorange errors. Further, a higher number of satellites with dual-constellation increases the possibility that satellite observations contain multiple faults. In order to ensure integrity and accuracy of the filter solution, it is crucial to provide sufficient fault-free GNSS measurements for the navigation filter. For this purpose, a new hybrid strategy is applied, combining conventional receiver autonomous integrity monitoring (RAIM) and innovative robust set inversion via interval analysis (RSIVIA). To further improve the performance, as well as the computational efficiency of the algorithm, the estimated velocity and its variance from the navigation filter is used to reduce the size of the RSIVIA initial box.  The designed approach is evaluated with recorded data from an extensive real-world measurement campaign, which has been carried out in GATE Berchtesgaden, Germany. In GATE, up to six Galileo satellites in orbit can be simulated. Further, the signals of simulated Galileo satellites can be manipulated to provide faulty GNSS measurements, such that the fault detection and identification (FDI) capability can be validated. The results show that the designed approach is able to identify the generated faulty GNSS observables correctly and improve the accuracy of the navigation solution. Compared with traditional RSIVIA, the designed new approach provides a more timely fault identification and is more computational efficient.
Egyes informatikai munkakörök betöltésének tendenciái a Diplomás Pályakövetési Rendszer (DPR) adatai alapjánEmployment trends of graduates in certain IT positions based on Graduate Career Tracking System
Authors: Seli Júlia , Hosznyák András , Harkányi Ádám Máté
Published: February 2021

A digitalizáció, az automatizáció és az ipar 4.0 jelentős befolyást gyakorol a munkaerőpiac alakulására. Az átalakulás hatására új szakmák keletkeznek, régiek tűnnek el vagy alakulnak át. Az Oktatási Hivatal által működtetett Diplomás Pályakövetési Rendszer (DPR) állami adatbázisokat pályakövetési céllal, „Big Data” szinten integráló modulja, az Adminisztratív Adatbázisok Egyesítése (DPR AAE) lehetőséget ad számunkra, hogy legalább a FEOR kódok adminisztratív nyilvántartásai segítségével teljeskörűen nyomon követhessük a végzett hallgatók különböző munkakörökben való elhelyezkedését, akár 7 éves időtávot is lefedve. Tanulmányunk célja betekintést adni arról, hogy miként változott 7 egymást követő évfolyamban az abszolvált hallgatók munkakörének megoszlása a végzés után másfél évvel egyes informatikához kötődő FEOR kódok vonatkozásában. Megmutatjuk egyúttal, hogy az informatika mellett milyen más képzési területek végzettjei töltenek be nagyobb arányban bizonyos informatikus munkaköröket.
Út az okos városoktól a városi rezilienciáig Way from smart city concepts to urban resilience
Authors: Nagy Zoltán , Szendi Dóra , Szép Tekla
Published: February 2021

Tanulmányunkban a Visegrádi Négyek 10 jelentős városát hasonlítjuk össze keresztmetszeti adatok (2015. év) alapján. Egy három (társadalmi, környezeti és gazdasági reziliencia) komponensből álló reziliencia index kialakításával mérjük ezen városok rugalmas ellenállóképességét, rangsoroljuk azokat. Jelentős eltérések tapasztalhatók a vizsgálatba bevont városok adaptációs kapacitása tekintetében. Habár gazdasági értelemben a Visegrádi Négyek fővárosai tekinthetők a legellenállóbbnak, ugyanakkor a társadalmi és a környezeti reziliencia komponens esetében eredményeik inkább átlagosak vagy átlagon aluliak. Kijelenthető, hogy egy város gazdasági sikere nem feltétlenül jelent nagyobb mértékű rezilienciát: a gazdasági értelemben sikeres város szükséges, de nem elégséges feltétele a reziliens városnak.
Vajon mit rejt a turizmus és az időskori foglalkoztatás metszete? Lehetőség a társadalom elöregedése okozta kihívások proaktív kezelésére Intersection of Elderly Employment and Tourism – Opportunities for proactively addressing the challenges brought by aging societies
Authors: Kovács Edina , Kiss Kornélia , Kenesei Zsófia , Kolos Krisztina , Michalkó Gábor , Pinke-Sziva Ivett
Published: February 2021

A társadalom elöregedésének folyamata olyan demográfiai jelenség, amely komoly gazdasági és társadalmi kihívásokat jelez előre, amelyek megoldásához átfogó stratégiára van szükség. Az idősek társadalmon belüli részarányának növekedésével párhuzamosan egyre szaporodik az elöregedéshez való alkalmazkodás sikerességét, valamint ennek területi ösz-szevethetőségét mérő indexek száma is. E nemzetközi mutatószámok tekintetében azonban Magyarország rendszerint a mezőny hátsó felében végez, amely azt feltételezi, hogy van még fejlődési lehetőség ezen a téren. Mélyinterjúkon alapuló kvalitatív kutatásunk az időskorúak szubjektív életminősége és a turisztikai szolgáltatói szerepvállalásuk közötti kapcsolatot tárja fel. Eredményeink azt mutatják, hogy ezen időskorúak készségei és tapasztalatai kiválóan alkalmassá teszik őket az örökségbemutatással összefüggő feladatok ellátására.
Ne vedd komolyan! Vagy mégis?Interjú Szentes Tamással
Authors: Sipos Júlia
Published: February 2021

Szentes Tamás akadémikus, a Budapesti Corvinus Egyetem professor emeritusa több tucatnyi tudományos könyve, köztük számos idegen nyelvű, külföldön megjelent műve után ezúttal egy egészen másfajta könyvecskével lepte meg az olvasókat. A Tinta Kiadónál jelent meg Ne vedd komolyan! Vagy mégis? avagy hogyan viseljük el ironikus humorral életünk visszássága-it címmel, „Ridendo dicere verum” alcímmel. Tudomány és irónia kapcsolatáról olvashatunk tehát, vagy inkább ironikusan szemlélt jelenségek, a tudomány által használt paradigmatikus formában megjelenített megfogalmazásait olvashatjuk. A szerző 1961-től 2002-ig, nyugdíjba vonulásáig volt egyetemünk állandó alkalmazottja, 1974-től egyetemi tanárként a Világgazdasági Tanszéken. Ő vezette be a multidiszciplináris fejlődéstanulmányokat, illetve az interdiszciplináris szemléletű fejlődésgazdaságtan tárgyat, és dolgozta ki a világgazdaságtan elméleti és módszertani alapjai tananyagát. Néhány évig (1995-1998) a Világgazdasági Tanszék vezetője volt. 2002-ben ment nyugdíjba, de professor emeritusként még tovább oktatott a „Nemzetközi kapcsolatok” multidiszciplináris doktori iskolában (amelynek első elnöke is volt), valamint az egyetem angol nyelvű programjában. Néhány éve már csak tanácsaival és publikációival segíti a tanszék munkáját.Az alcím, vagyis a Ridendo dicere verum, nevetve kimondani az igazságot, komoly intellektuális kihívás, mert a humor az egyik legösszetettebb kognitív képességeket igénylő sajátosság. Szentes Tamást Sipos Júlia kerestemeg kérdéseivel.
FinTech – a jövő? FinTech – Is this the future?
Authors: Szobonya Réka
Published: February 2021

A pénzügyi szektorban terjedő innovációk a fogyasztói társadalom kényelmi igényét egyre magasabb szinten elégítik ki. Az internet hullámaira csatlakozó eszközökön keresztül a hagyományos pénzügyi szervezetek és a piacra belépő FinTech cégek újabb és újabb termékeket fejlesztenek ki, melyek nagy valószínűséggel számottevően megváltoztatják a pénz-ügyi környezetet. Az alkalmazkodás nélkülözhetetlen komponense – pénzügyi kultúra, a digitális kompetenciák, a bizalom, az elfogadás mellett – a tájékozódás az adott közegben megjelenő materiális és immateriális tényezők terén. Tanulmányomban a pénzügyi intézmények, a digitális technológiák, termékek és szolgáltatások terén végbement változások, átalakulások produktumait és azok hatásait foglalom össze – a teljesség igénye nélkül.
Berend T. Iván: Naplementék (történelmi korszakvázlatok)
Authors: Okolicsányi Ádám
Published: February 2021

Az Éghajlat Könyvkiadó interjúköteteinek sorában jelent meg a Berend T. Ivánnal készített interjúsorozat. A mű alapötlete igen egyszerű, ám annál szebben nyer kifejezést a Naplementék cím allegóriájában: a Berend T. Iván által megélt korszakváltásokat követi nyomon, gyakori kitekintésekkel az európai vagy világtörténelemre, de mindig a megkérdezett szempontjából. Az MTA volt elnöke, a Marx Károly Közgazdaságtudományi Egyetem volt rektora pedig minden alkalmat kihasznál, hogy azzal a lelkesedéssel és éleslátással meséljen az olvasónak az általa is megélt történelemről, amely gondolatébresztő, hasznos tudással látja el.
How are the Portuguese coping with the mandatory confinement by COVID-19? Association between mental health and coping strategies
Authors: Jarego Margarida , Pimenta Filipa , Pais-Ribeiro José , M. Costa Rui , Patrão Ivone , Coelho Lina , Ferreira-Valente Alexandra
Published: February 2021

Background. This study aimed at assessing the mental health status of adults living in Portugal during the national lockdown of March 2020 to May 2020, how study participants coped with stress during the national lockdown, as well as the association between coping responses and mental health status.

Methods. 430 adults from the general population living in Portugal completed measures of mental health status and coping.

Results. Participants reported a mental health status in the normal range. Most commonly used coping responses were acceptance, planning and active coping. The use of instrumental and emotional support, self-blame, venting, denial, behavioural disengagement, and substance use were associated with poorer mental health. Active coping, positive reframing, acceptance, and humour were associated with better mental health. However, only positive reframing and humour significantly predicted better mental health, while only substance use predicted poorer mental health.

Conclusions. Findings suggest that there was not a significant negative impact of the Portuguese national lockdown in the adults living in Portugal. Findings supported positive reframing and humour as being adaptive coping responses in this context.

These responses should be encouraged by healthcare professionals and targeted in the context of psychosocial intervention programs directed to most vulnerable populations.
Poster for an Organic Fertilizer
Authors: Perera Kavindu Dilshan
Published: February 2021

This poster was actually designed for the academic project known as the Entrepreneurship Based Project which launchedin the Faculty of Management and Finance University of Colombo, Sri Lanka. The Project is a part of the Bachelor of Business Administration Degree program at the University. The Poster shows the benefits of Organic fertilizer products.
Perbandingan Model Logistic Regression dan Artificial Neural Network pada Prediksi Pembatalan Hotel
Authors: Putra Moch Shandy Tsalasa , Azhar Yufis
Published: February 2021

Prediction for canceled booking hotels is an important part of hotel revenue management systems in the modern era. Because the predicted result can be used for the optimization of hotel performance. The application of machine learning will be very helpful for predicting canceled booking hotels because machine learning can process complex data. In this research, the proposed methods are Artificial Neural Network (ANN) and Logistic Regression. Later it will be done five times experiments with hyperparameter tuning to see which method is the most optimal to do prediction canceled booking hotel. From five times experiments, experiments number five (logistic regression with GridSearchCV) is the most optimal for predicting canceled booking hotels, with 79.77% accuracy, 85.86% precision, and 55.07% recall.
Usability Testing pada Sistem Informasi Akademik IAIN Salatiga Mengunakan Metode System Usability Scale
Authors: Prabowo Mei , Suprapto Agung
Published: February 2021

One of the goals of implementing a smart campus is to improve public services. Whereas the Academic Information System (Siakad) is a very important type of management information system (MIS) digital service. To find out the quality of service from the viewpoint of the user of this information system, a usability test was made. Usability is a qualitative analysis in determining the quality of an information system based on the user. The purpose of this study is to conduct usability testing SIAKAD in IAIN Salatiga using the System Usability Scale (SUS) method. Based on the usability test results, the majority of respondents use and utilize this information system well, this is proven by the value of the test results of 84,75. The evaluation results show that the Academic Information System at IAIN Salatiga is categorized as excellent.
Ketuntasan Belajar Siswa Pada Mata Pelajaran PAI Melalui Metode Kisah
Authors: Kuswoyo Pandi
Published: February 2021

This study aims to improve the mastery of learning through the application of methods of stories on the subjects of Islamic religious education aspects of morality. This is a classroom action research that is carried out in three cycles. The cycle 1, the average of the student learning achievement values reached 82 with the completeness of 86%. Cycle 2, the average of the student learning achievement values reached 91.79 with the completeness of 92%.While on cycle 3, the average of the student learning achievement values reached 92.14 with the completeness of 96%. In Addition, Increased activity of teachers in the learning process also tends to increase of the cycle I reached 63.6%, the second cycle Increased to 85.5%, and 96.4%.
Deradicalization of Religion Through Pluralism Education Methods in Jembrana Bali
Authors: Made Saihu
Published: February 2021

Deradicalization through education is one of the main agendas in counteracting the massive spread of radicalism in Indonesia. This study aims to describe the effectiveness of the religious pluralism education method from the perspective of "Allison Cumming-McCann" at SMPN 4 and SMAN 1 Negara Jembrana to implement deradicalization. This study uses a qualitative method with the type of case study (multiple cases). Data were obtained through observation and unstructured interviews. This study's results indicate that the optimization of several religious pluralism education methods of "Allison Cumming-McCann" is in the form of contribution, enrichment, and decision-making & social action methods. Even though Muslims' position in the two educational institutions is a minority, this optimization is expected to strengthen harmonious relations between students of different religions and cultures. To a certain extent, there is also active involvement between students to prepare for each religious ceremony. This study provides an example of a pluralism educational model in a multicultural environment in the deradicalization effort through education.
The Paradox of Pesantren Education in the Implementation of Islamic Law: Study of Pesantren Kyai Notion in Mojokerto
Authors: Ainul Yaqin  , Rozi Syaikhu , Sham Fariza Md
Published: February 2021

The teaching of classical books (Kitab Kuning) is a tradition of pesantren education that has lasted a long time. The teaching aims so that students and Muslims can implement the teachings contained in classical books in everyday life. The purpose of this study is to reveal the paradoxical problems faced by santri and Muslims regarding the differences between the content of classical books and their daily application. This research focuses on pesantren Kyai in Mojokerto regarding this paradoxical problem, which is a determining factor in the style and variety of pesantren education management. This study used qualitative methods. Data were collected using interviews, observation, and documentation techniques.  This study's results indicate that Kyai pesantren's notions in Mojokerto can be categorized in the textual-moderate category with the characteristics that they cannot accept the contextual interpretation of Islamic law and tend to be textual. However, this attitude does not encourage Kyai to impose Islamic law and does not force the form of an Islamic state. The education style that results from this notion is that pesantren education tends to be closed and does not accept religious values changes. However, it is open and accepts changes in general education by opening formal educational institutions. This study provides an overview of the style of pesantren education and the factors that influence it.
Politics of Education in Curriculum Development Policy in Indonesia from 1947 to 2013: A Documentary Research
Authors: Alhamuddin  , Fanani Ahmad , Yasin Ilyas , Murniati Andi
Published: February 2021

The dynamics of curriculum development in Indonesia from 1947 to the latest 2013 curriculum cannot be separated from political influence. This paper investigates the politics of educational policy in Indonesia’s curriculum development from 1947 to 2013, a critical analysis of various polemics about Indonesian education’s aims and contents in schools. This paper is documentary research, which refers to related previous documents or literature. The study results indicate that the development of Indonesia’s education curriculum is closely influenced by political, economic, social, cultural, and globalization factors. The formulated curriculum content cannot be separated from these factors’ influence, as the 2013 curriculum was recently implemented. Of all these factors, government interests and political paradigms have the most significant influence in changing, developing, and refining the curriculum from time to time. The 2013 curriculum policy is intended to improve the various deficiencies that existed in the previous curriculum. The 2013 curriculum is structured by developing and strengthening attitudes, knowledge, and skills in a balanced manner. This research’s implication is hoped that policymakers can consider it in developing curriculum in Indonesia.
THE USE OF DIGITAL SIGNAL PROCESSING AND A NEURAL NETWORK WHEN GENERATING A FORECAST OF TIME SERIES OF DATA FOR THE PURPOSE OF DETECTING ANOMALIES IN THE IN THE AUTOMATED CONTROL OF TECHNOLOGICAL PROCESSES
Authors:   Candidate of Sciences in Technology,  Department of Information Security, Department of Information Technology Federal State Autonomous Educational Institution of Higher Education «South Ural State University (national research university), Ragozin A. N.
Published: February 2021

n order to detect anomalies and improve the quality of forecasting dynamic data flows observed from sensors in Industrial Control System (ACS)., it is proposed to use a predictive mod-ule consisting of a series-connected digital signal processing unit (DSP) and a predictive unit using a neural network (predictive autoencoder ( Auto Encoder), predictive Autoencoder (PAE)). The study showed that the preliminary DSP block of the predicted input signal, consisting of a parallel set (comb) of digital low-pass filters with finite impulse responses (FIR-LPF), leads to a non-equilibrium account of the correlation relationships of the time samples of the input signal and to increase the accuracy of the final prediction result. The predicted autoencoder (PAE) pro-posed and considered in the work, in addition to restoring the input signal or part of the input signal at the PAE output, also generates the predicted samples of the input signal for the speci-fied number of «forward» time steps at the output, which increases the accuracy of the predic-tion result. The reduction of the forecast error occurs due to the imposition of restrictions in the formation of the forecast, that is, an additional requirement to restore the input samples of the samples – «stabilizers» at the NS output. The introduction of «stabilizers» increases the accuracy of the prediction result.
THE FEATURES OF MANDATORY ACCESS CONTROL MODEL IN MODERN UNAUTHORIZED ACCESS DATA PROTECTION TOOLS
Authors:   senior teacher of the  Training and Scientific Center “Information Security”,  Ural  Federal  University  named  after  the  first  President  of  Russia  B.N.Yeltsin., Kuts D. V. , Porshnev S. V. ,   Doctor  of  Technical  Sciences,  Full  Professor,  Head  of  Unit,  Training  and  Scientific  Center  “Information  Security”,  Ural  Federal  University  named  after  the  first  President  of  Russia  B.N.Yeltsin.
Published: February 2021

This article describes the features of mandatory access control model in unauthorized ac-cess data protection tools, which can affect its efficiency. Also, some flaws of unauthorized ac-cess data protection tools and possible scenarios of unauthorized access bypassing these tools are analyzed. The countermeasures and methods of its application, eliminating detected flaws are offered. The conclusions about necessarity of analyze of unauthorized access data protec-tion tools policies and revision of its severeness, if it is necessary, were made.
EVOLUTION OF INFORMATION SECURITY SYSTEMS IN VIDEO GAMES
Authors:   Student  of  Department  of  Information  Security,  South  Ural State University (National Research University), Anfinogenov M. V. , Antyasov I. S. ,   Senior  Lecturer  of  Department  of  Information  Security,  South  Ural State University (National Research University).
Published: February 2021

This article covers the video games as a unique phenomenon in the information environ-ment, the development of security technologies and unauthorized access methods since the first video game release until the position of the video game industry in our time. Represented a step change in the interaction systems, the technical features of both hardware and software security which were used by video game developers and companies producing platforms. The analysis of the hacking techniques and methods intended for these protection systems and re-lated global incidents is made. Illustrated the formation and development of security systems of the video game consoles of subsequent generations under the influence of the mistakes and shortcomings in the data security of the prior console generations. The process of centralization and generalization of the user data integrity systems in the modern world is considere
Wstęp. Literatura Europy Środkowej w nowym tysiącleciu
Authors: Šidáková Fialová Alena , Scheibner Tamás , Németh Vítová Lenka
Published: February 2021

Wstęp. Literatura Europy Środkowej w nowym tysiącleciu Dzień
The Figure of Ophelia in Expressionist Poetry: German and Czech Comparison
Authors: Malý Radek
Published: February 2021

The study deals with the rendition of the figure of Ophelia in Czech modern poetry in comparison with the poetry of European Expressionism. The image of Ophelia’s aesthetic death from Shakespeare’s drama Hamlet has influenced and inspired a whole range of artworks. It strongly reverberated in German Expressionist poetry, especially that by Georg Heym, Gottfried Benn and Georg Trakl. The Czech poets who approached this topic in the spirit of Expressionism include Jan Skácel, Vladimír Holan and Jiří Orten. The study further addresses these works in the light of the Ophelia complex as defined by Bachelard.
Literary Internet: Online Criticism and Literary Communication
Authors: Winiecka Elżbieta
Published: February 2021

This article is devoted to the transformations that literary communication has undergone on the Internet. The author describes how literary criticism and its role in the digital medium has changed, indicates the deep cultural changes resulting from the development of forms of communication in social media, and characterizes how the Internet has transformed literature. New media has given rise to new literary genres; it has also altered literature itself, recasting it in a hybrid form on the border between the literature and audiovisual media. The ongoing changes do not pose a threat to printed literature, but are an expression of the strength of the Internet’s impact on literary communication and its participants. It is necessary to refrain from easy evaluations of the ongoing processes and to focus on accurately describing, analyzing and interpreting them as a new and relatively unknown part of the expanding literary field.
Hot Deformation Behavior of Al-20Si-5Fe-2Ni Alloy Obtained by Spray Forming
Authors: Menapace C. , Menapace L. , Perricone G.
Published: February 2021

The hot deformation behavior of an aluminum alloy containing 20 % silicon, 5 % iron, and 2 % nickel produced by spray forming has been investigated through hot compression tests. Tests were carried out at 400°C, 450°C, and 500°C and 2 strain rates (0.25 and 1 s−1). It was found that, under the deformation conditions applied, stress–strain curves were characterized by a distinct stress peak or a multipeaks trend indicating the occurrence of dynamic recrystallization (DRX). Microstructural observations, together with X-ray diffraction (XRD) analysis, also indicated a change in the type of intermetallics during hot deformation, with a reduction of δ-Al4FeSi2 and a corresponding increase of the stable β-Al5FeSi phase.
Support Vector Machine-based Soft Sensors in the Isomerisation Process
Authors: Herceg Srećko , Ujević Andrijić Željka , Bolf Nenad
Published: February 2021

This paper presents the development of soft sensor empirical models using support

vector machine (SVM) for the continual assessment of 2,3-dimethylbutane and 2-methylpentane mole percentage as important product quality indicators in the refinery isomerisation process. During the model development, critical steps were taken, including selection and pre-processing of the industrial process data, which are broadly discussed in this paper. The SVM model results were compared with dynamic linear output error model and nonlinear Hammerstein-Wiener model. Evaluation of the developed models on independent data sets showed their reliability in the assessment of the component contents. The soft sensors are to be embedded into the process control system, and serve primarily as a replacement during the process analysersb failure and service periods.
Vicia faba Crop Residues for Sustainable Electricity Generation Using a Sludge-based Microbial Fuel Cell
Authors: Mamani-Asqui Leonard Javier , Peredo-Berlanga Lucero Nataly , Roque Rodríguez Francisco Javier , Salazar-Banda Giancarlo Richard
Published: February 2021

Microbial fuel cells (MFC) simultaneously degrade organic substrates and generate electricity in a sustainable and eco-friendly way. Here, we built a 4-unit MFC and studied

the efficiency of MFC at different conditions, including pH, substrate concentration of

Vicia faba agricultural wastes with exoelectrogenic bacteria P. aeruginosa. The exoelectrogenic bacteria were obtained from industrial effluents and used to inoculate the MFCs. The optimized conditions in terms of yielding maximum potential of 802 mV, yielding maximum power density of 283 mW mb2 were reported at a substrate concentration of 6 g Lb1 of V. faba waste and pH of 5.5, corresponding to a current density 1255.93 mA mb2. Using exoelectrogenic bacteria from industrial effluents and agricultural wastes resulted in efficient MFC. Thus, the developed MFCs using V. faba agricultural wastes can be used in rural areas that have limited access to electricity, by reusing agricultural wastes and concomitant electricity generation.
Reactive Distillation for the Production of Cyclohexanol
Authors: Sun Dahai , Tian Hui , Sun J. , Xu W.
Published: February 2021

Cyclohexanol is an organic chemical intermediate product widely used in chemical

industry and commonly produced by cyclohexene hydration. Because of the low mutual

solubility of cyclohexene and water, the reaction is limited by chemical equilibrium,

which has the disadvantage of low conversion of cyclohexene. In this paper, the hydration reaction of cyclohexene catalysed by A-36 cation exchange resin catalyst was analysed by Aspen Plus V8.6 simulation software in the presence of isophorone as cosolvent.

The process model of synthesising cyclohexanol by catalytic distillation was verified by

process experiments. The simulation experiments were carried out using the process

model, and suitable operating conditions of the catalytic distillation column were obtained. These are: ketene feed ratio 1.5, alkene/water ratio 0.5, distillation stage trays 5,

reaction stage trays 12, stripping stage trays 6, cyclohexene feed at the 18th tray, water

and isophorone feed at the 5th tray, reflux ratio 3, feed ratio (D/F) 0.25. Under these

operating conditions, the conversion of cyclohexene can reach 40.63 %.
Understanding Caking Phenomena in Industrial Fertilizers
Authors: Ulusal Aysu , Avsar Cemre
Published: February 2021

One of the most important problems of the fertilizer industry is that fertilizers show caking tendency during transportation and storage. Caking occurs as a result of interaction at the contact points formed between solid fertilizer particles. These interactions, also called contact mechanisms, are activated by a number of properties that fertilizers have and by environmental conditions. Prevention of caking mechanism is a substantial research subject that directly affects the quality and financial value of the final product and ensures its applicability. Fertilizer in good quality can provide ease in agricultural applications, and directly affect plant nutrition and crop productivity. At this point, there are various promoter practices for obtaining the free-flowing property in fertilizers that can be maintained or suggested during or after production, both in industry and in R&D studies. In order to develop new process control points in the industry, it is important to understand the factors that cause caking and the mechanism of physicochemical interactions that progress depending on these factors. In addition, it is essential to improve the storage conditions of the fertilizer, as well as to maintain its quality until end-use. This paper focuses on the caking behavior of fertilizers in detail, giving brief information about the prevention of caking and various types of anticaking agents.