bluuebunny/crossref_metadata_2025 huggingface dataset:
FIGURE 1 from Exploring the Onset and Progression of Prostate Cancer through a Multicellular Agent-based Model
Authors: Passier Margot , van Genderen Maisa N.G. , Zaalberg Anniek , Kneppers Jeroen , Bekers Elise M. , Bergman Andries M. , Zwart Wilbert , Eduati Federica
Published: August 2023

Overview of the agents and actions they can perform during each model iteration. The simulation starts with luminal cells (LC) and basal cells (BC) that can proliferate, die, or idle, all within physiologic regions and with fixed probabilities. The starting geometry also contains quiescent fibroblasts (F) and the passive agents (basement membrane and ECM), macrophages enter throughout the simulation. LCs can gain mutations, resulting in an increased M1-macrophage influx, once these mutated cells are sensed by macrophages. These mutated cells (TU) can additionally break down basement membrane and ECM and affect macrophage and fibroblast differentiation upon reaching mutation thresholds. Differentiated fibroblasts (CAF) proliferate, die, and can perform tumor-promoting actions. Just as the differentiated M2 macrophages, they stimulate TU proliferation and allow for TU migration. Macrophages (M1 and M2) can also kill tumor cells and die or migrate. Image created with BioRender.com.
Data from Whole genome CpG-resolution DNA methylation profiling of HNSCC reveals distinct mechanisms of carcinogenesis for fine-scale HPV+ cancer subtypes
Authors: Qin Tingting , Li Shiting , Henry Leanne E , Chou Elysia , Cavalcante Raymond G , Garb Bailey F , D'Silva Nisha J. , Rozek Laura S. , Sartor Maureen A
Published: August 2023

Abstract
DNA methylation is a vital early step in carcinogenesis. Most findings of aberrant DNA methylation in head and neck squamous cell carcinomas (HNSCC) are array-based with limited coverage and resolution, and mainly explored by human papillomavirus (HPV) status, ignoring the high heterogeneity of this disease. In this study, we performed whole-genome bisulfite sequencing (WGBS) on a well-studied HNSCC cohort (n=36) and investigated the methylation changes between fine-scaled HNSCC subtypes in relation to genomic instability, repetitive elements, gene expression, and key carcinogenic pathways. The previously observed hypermethylation phenotype in HPV-positive (HPV+) tumors compared to HPV-negative tumors was robustly present in the immune-strong (IMU) HPV+ subtype but absent in the highly keratinized (KRT) HPV+ subtype. Methylation levels of IMU tumors were significantly higher in repetitive elements, and methylation showed a significant correlation with genomic stability, consistent with the IMU subtype having more genomic stability and better prognosis. Expression quantitative trait methylation (cis-eQTM) analysis revealed extensive functionally-relevant differences, and differential methylation pathway analysis recapitulated gene expression pathway differences between subtypes. Consistent with their characteristics, KRT and HPV-negative tumors had high regulatory potential for multiple regulators of keratinocyte differentiation, which positively correlated with an expression-based keratinization score. Together, our findings revealed distinct mechanisms of carcinogenesis between subtypes in HPV-positive HNSCC and uncovered previously ignored epigenomic differences and clinical implications, illustrating the importance of fine-scale subtype analysis in cancer.
MiR-193b-3p Regulates TLR4 Expression to Inhibit Inflammation by Targeting ETS1 in Allergic Rhinitis
Authors: Jing Yunlong , Xie Jiang , Huang Min , Zhao Weiliang , Long Songliang , Zhao Sijun
Published: August 2023

Introduction: Allergic rhinitis (AR) is identified as a multifactorial disease caused by the interaction of genes and surroundings, which is difficult to cure. MicroRNAs were reported to be engaged in AR development. Here, we aimed to seek the anti-inflammatory effects and regulatory mechanism of miR-193b-3p in AR. Methods: Mucosal tissues from AR patients and healthy volunteers were collected, and human nasal epithelial cells (HNECs) were treated with IL-13 to establish a cell model of AR. The gene expression of miR-193b-3p, ETS1, TLR4, GM-CSF, eotaxin, and MUC5AC was determined by RT-qPCR. The protein levels of ETS1 and TLR4 were examined using Western blot. Enzyme-linked immunosorbent assay was performed to measure protein concentration of GM-CSF, eotaxin, and MUC5AC in cell supernatant. Dual luciferase assay was applied to verify the interaction among miR-193b-3p, ETS1, and TLR4. Results: The expression of miR-193b-3p was declined in clinical samples from AR patients and in IL-13-induced HNECs, while the mRNA and protein levels of ETS1 and TLR4 were elevated. MiR-193b-3p overexpression or ETS1 silencing notably decreased the mRNA and protein levels of GM-CSF, eotaxin, and MUC5AC in IL-13-treated HNECs. Mechanistically, miR-193b-3p directly combined with ETS1 to silence ETS1 expression. ETS1 promoted the transcriptional activity of TLR4 through interacting with TLR4 promoter. Furthermore, rescue experiments revealed that ETS1 overexpression abolished miR-193b-3p sufficiency-mediated suppression of the mRNA and protein levels of GM-CSF, eotaxin, and MUC5AC in IL-13-treated HNECs. Similarly, TLR4 overexpression compromised the inhibitory impacts of ETS1 downregulation on the mRNA and protein levels of GM-CSF, eotaxin, and MUC5AC in IL-13-induced HNECs. Discussion: MiR-193b-3p repressed IL-13-induced inflammatory response in HNECs by suppressing ETS1/TLR4 axis, which indicated that miR-193b-3p might be a therapeutic target for AR treatment.
Construction of Prognostic Nomogram in Patients with N3-Stage Nasopharyngeal Carcinoma
Authors: Cao Wenmiao , Li Xiaoxin , Yang Jianqi , Xing Enming , Wu Wenjuan , Ge Yizhi , Wang Buhai
Published: August 2023

Introduction: The aim of the study was to retrospectively identify the metastatic influence factors and predict the prognosis and develop an individualized prognostic prediction model for patients with N3-stage nasopharyngeal carcinoma (NPC). Methods: The study collected 446 NPC patients with N3 stage from the Surveillance, Epidemiology, and End Results database between 2010 and 2015. The patients were classified into subgroups based on the histological types and metastatic status. Multivariable logistic, Cox regression, and Kaplan-Meier method with the log-rank test were performed. The nomogram model was created using the prognostic factors identified from Cox regression analysis. The predictive accuracy was determined based on the concordance index (c-index) and calibration curves. Results: The 5-year overall survival (OS) of the NPC patients with N3 stage was 43.9%, and the prognosis of patients without any distant metastases was largely longer than that with metastases. No difference was observed between different pathological types in the entire cohort. However, patients with non-keratinized squamous cell carcinoma had a better OS than that of the patients with keratinized squamous cell carcinoma in a nonmetastatic subgroup. Using the Cox regression analysis results, the nomogram successfully classified these patients into low- and high-risk subgroups and presented the survival difference. The c-index of the nomogram for predicting the prognosis was satisfactory. Conclusion: This study identified metastatic risk factors and developed a convenient clinical tool for the prognosis of NPC patients. This tool can be used for individualized risk classification and decision-making regarding treatment of NPC patients with N3 stage.
Diagnostic Gene Panel Testing in (Non)-Syndromic Patients with Cleft Lip, Alveolus and/or Palate in the Netherlands
Authors: Wurfbain Lisca Florence , Cox Inge Lucia , van Dooren Maria Francisca , Lachmeijer Augusta Maria Antonia , Verhoeven Virginie Johanna Maria , van Hagen Johanna Maria , Heijligers Malou , Klein Wassink - Ruiter Jolien Sietske , Koene Saskia , Maas Saskia Mariska , Veenstra - Knol Hermine Elisabeth , Ploos van Amstel Johannes Kristian , Massink Maarten Pieter Gerrit , Mink van der Molen Aebele Barber , van den Boogaard Marie-José Henriette
Published: August 2023

Objectives: Clefts of the lip, alveolus and/or palate (CLA/P) are the most common craniofacial congenital malformations in humans. These oral clefts can be divided into non-syndromic (isolated) and syndromic forms. Many cleft-related syndromes are clinically variable and genetically heterogeneous, making it challenging to distinguish syndromic from non-syndromic cases. Recognition of syndromic/genetic causes is important for personalized tailored care, identification of (unrecognized) comorbidities, and accurate genetic counseling. Therefore, next generation sequencing (NGS)-based targeted gene panel testing is increasingly implemented in diagnostics of CLA/P patients. In this retrospective study, we assess the yield of NGS gene panel testing in a cohort of CLA/P cases. Methods: Whole exome sequencing (WES) followed by variant detection and interpretation in an a priori selected set of genes associated with CLA/P phenotypes was performed in 212 unrelated CLA/P patients after genetic counseling between 2015 and 2020. Medical records including family history and results of additional genetic tests were evaluated. Results: In 24 CLA/P cases (11.3%), a pathogenic genetic variant was identified. Twenty out of these 24 had a genetic syndrome requiring specific monitoring and follow-up. Six of these 24 cases (25%) were presumed to be isolated CLA/P cases prior to testing, corresponding to 2.8% of the total cohort. In eight CLA/P cases (3.8%) without a diagnosis after NGS-based gene panel testing, a molecular diagnosis was established by additional genetic analyses (e.g., SNP array, single gene testing, trio WES). Conclusion: This study illustrates NGS-based gene panel testing is a powerful diagnostic tool in the diagnostic workup of CLA/P patients. Also, in apparently isolated cases and non-familial cases, a genetic diagnosis can be identified. Early diagnosis facilitates personalized care for patients and accurate genetic counseling of their families.
Cruciferous Vegetable Intake and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis
Authors: Long Jiaye , Liu Zhaohui , Liang Shuai , Chen Baoxiang
Published: August 2023

Introduction: The relationship between cruciferous vegetables and prostate cancer (PCa) risk remains contentious. This study aimed to assess the association between consuming cruciferous vegetables and PCa risk. Methods: We carried out a systematic search through PubMed, Embase, Web of Science, and the Cochrane Library until September 20, 2022. The results of the article will be analyzed using the Stata 14 software. This meta-analysis was reported as directed by the PRISMA guidance, and the study protocol was recorded in PROSPERO (CRD42022361556). Results: 7 case-control studies and 9 cohort studies were eventually included, including 70,201 PCa cases and 1,264,437 members. The higher the intake of cruciferous vegetables, the lower the risk of PCa. In comparison to the lowest dose of cruciferous vegetables, the overall relative risk (RR) of cruciferous vegetables having the highest dose was 0.87 (95% confidence interval [CI]: 0.80–0.95; I2 = 59.2%). A significant linear trend (p = 0.002) was observed for the association, with a combined RR of 0.955 (95% CI: 0.928–0.982) for every 15 g of cruciferous vegetables per day. Conclusions: The study revealed that consumption of cruciferous vegetables may be linked to reduced PCa risk.
Onychocytic Matricoma Presenting as Longitudinal Melanonychia in a Skin of Color Patient
Authors: Alvarez Gabriella , Kha Connie , Selim M. Angelica , Fresco Amber
Published: August 2023

Introduction: Onychocytic matricoma (OCM) is a benign acanthoma of the nail matrix that presents with longitudinal melanonychia and nail thickening. Only 18 previously reported cases of OCM are in the literature since it was first described in 2012. Case Presentation: The purpose of this case report was to report a unique presentation of OCM in the toenail of a Black patient as well as to review the clinical presentation, histologic features, and management of this rare entity. Previously described cases presented on the fingernails and were predominantly in white males. Conclusion: OCM is a benign entity that may mimic a nail unit melanoma or squamous cell carcinoma especially when pachyonychia is present. Despite some clinical clues to suggest a diagnosis of OCM, a nail matrix biopsy is often required to rule out malignancy.
Phacoemulsification with and without iStent: A Systematic Review and Meta-Analysis of Comparative Studies
Authors: Kahale Francesca , Chanbour Wassef , El Zein Lulwa , Brenner Jason , You Jae Young , Melki Samir
Published: August 2023

Background: The iStent (Glaukos Corporation; Laguna Hills, CA, USA) is one of the minimally invasive glaucoma devices. It can be inserted at the time of phacoemulsification or as a stand-alone procedure to lower the intraocular pressure (IOP). Objective: Our aim was to conduct a systematic review and meta-analysis comparing the effect of iStent insertion at the time of phacoemulsification with phacoemulsification alone in patients with ocular hypertension or open-angle glaucoma. Methods: We searched EMBASE, MEDLINE (OVID and PubMed), CINAHL, and Cochrane Library for articles published between 2008 and June 2022 (PRISMA 2020 for the checklist). Studies comparing the IOP-lowering effect of iStent with phacoemulsification versus phacoemulsification alone were included. The endpoints were IOP reduction (IOPR) and the mean reduction in the number of glaucoma drops. A quality-effects model was used to compare both surgical groups. Results: Ten studies were included, reporting on 1,453 eyes. Eight hundred fifty three eyes had the combined iStent and phacoemulsification, and 600 eyes underwent phacoemulsification alone. IOPR was higher in the combined surgery at of 4.7 ± 2 mm Hg compared to 2.8 ± 1.9 mm Hg in phacoemulsification alone. A greater decrease in postoperative eye drops was noted in the combined group having a decrease of 1.2 ± 0.3 eye drops versus of 0.6 ± 0.6 drops in isolated phacoemulsification. The quality effect model showed an IOPR weighted mean difference (WMD) of 1.22 mm Hg (confidence interval [CI]: [–0.43, 2.87]; Q = 315.64; p < 0.01; I2 = 97%) and decreased eye drops WMD 0.42 drops (CI: [0.22, 0.62]; Q = 42.6; p < 0.01; I2 = 84%) between both surgical groups. Subgroup analysis shows that the new generation iStent may be more effective in reducing IOP. Conclusion: iStent has a synergetic effect with phacoemulsification. The reduction of IOP and glaucoma eye drops was higher when iStent is combined with phacoemulsification compared with isolated phacoemulsification.
TRAPPC9-Related Intellectual Disability: Report of Two New Cases and Review of the Literature
Authors: Uctepe Eyyup , Yesilyurt Ahmet , Esen Fatma Nisa , Tümer Sait , Mancılar Hanifenur , Sonmez Fatma Mujgan
Published: August 2023

Introduction: Hereditary forms of intellectual disability (ID), an estimated prevalence ranging between 1% and 3% in the general population, are among the most important problems in health care. Especially, autosomal-recessive ID has a very heterogeneous molecular basis and a lack of specific phenotypic features. Methods: Here, we report on two unrelated patients with autosomal-recessive ID, microcephaly, and autistic features and review the patients with TRAPPC9-related ID. Whole-exome sequencing and array CGH were performed for molecular diagnosis of the patients. Results: The first case has a microdeletion on chromosome 8q24.23-q24.3 region which is 1.7 Mb in length and includes the last 5 exons of TRAPPC9, and c.3435delG [p.Thr1146Profs*8] deletion. The second case has a homozygous missense c.623A>C (p.His208Pro) variant in TRAPPC9 which is detected by means of whole-exome sequencing study of the proband. We also reviewed the clinical findings and mutation spectrum of all patients with TRAPPC9-related ID reported so far. Conclusions: Our study showed that the most consistent clinical findings for TRAPPC9-related ID are ID, microcephaly, and some structural brain MRI abnormalities. The mutations in the TRAPPC9 are scattered throughout all exons of TRAPPC9 indicating there is no hot spot mutation region in this gene.
Estrogen‐Related Receptor Gamma Gene Therapy Promotes Therapeutic Angiogenesis and Muscle Recovery in Preclinical Model of PAD
Authors: Sopariwala Danesh H. , Rios Andrea S. , Saley Addison , Kumar Ashok , Narkar Vihang A.
Published: August 2023

Background

Peripheral arterial disease and critical limb ischemia are cardiovascular complications associated with vascular insufficiency, oxidative metabolic dysfunction, and myopathy in the limbs. Estrogen‐related receptor gamma (ERRγ) has emerged as a dual regulator of paracrine angiogenesis and oxidative metabolism through transgenic mouse studies. Here our objective was to investigate whether postischemic intramuscular targeting of ERRγ via gene therapy promotes ischemic recovery in a preclinical model of peripheral arterial disease/critical limb ischemia.

Methods and Results

Adeno‐associated virus 9 (AAV9)
Esrrg
gene delivery vector was developed and first tested via intramuscular injection in murine skeletal muscle. AAV9‐Esrrg robustly increased ERRγ protein expression, induced angiogenic and oxidative genes, and boosted capillary density and succinate dehydrogenase oxidative metabolic activity in skeletal muscles of C57Bl/6J mice. Next, hindlimb ischemia was induced via unilateral femoral vessel ligation in mice, followed by intramuscular AAV9‐Esrrg (or AAV9‐green fluorescent protein) gene delivery 24 hours after injury. ERRγ overexpression increased ischemic neoangiogenesis and markers of endothelial activation, and significantly improved ischemic revascularization measured using laser Doppler flowmetry. Moreover, ERRγ overexpression restored succinate dehydrogenase oxidative metabolic capacity in ischemic muscle, which correlated with increased mitochondrial respiratory complex protein expression. Most importantly, myofiber size to number quantification revealed that AAV9‐Esrrg restores myofibrillar size and mitigates ischemia‐induced myopathy.

Conclusions

These results demonstrate that intramuscular AAV9‐Esrrg delivery rescues ischemic pathology after hindlimb ischemia, underscoring that
Esrrg
gene therapy or pharmacological activation could be a promising strategy for the management of peripheral arterial disease/critical limb ischemia.
Personality and behavioural syndromes in wild-caught Namaqua rock mice (Micaelamys namaquensis)
Authors: Oosthuizen Tasha , Lutermann Heike
Published: August 2023

Rodents from the southern hemisphere are underrepresented in studies of animal personality. In the current study, we assessed personality in 22 wild-caught Namaqua rock mice (Micaelamys namaquensis), a species that is widespread throughout southern Africa. We assessed exploration, aggression and boldness scores and evaluated the effects of intrinsic (i.e., sex) and extrinsic (i.e., captive environment) factors on personality. Rock mice showed personality and behavioural plasticity. While sex alone was not an important factor in the personality of this species, the initial trial differed significantly from subsequent ones, indicative of capture stress and/or subsequent habituation. We found a behavioural syndrome between aggressiveness and exploration, as well as between aggressiveness and boldness scores. Thus, our study extends our knowledge of personality and behavioural syndrome in wild rodents and suggests a role of sex on habituation. The fitness implications of these findings for the study species merit further study in the future.
Hugo’s Moments, Maria’s Everyday Chores? Discords in the Search for Grotian Moments for Women’s Rights in International Law
Authors: Tallgren Immi
Published: August 2023

This chapter would have liked to invite its readers on an exciting but breath-taking journey through the historical landscapes of international law, since ‘time immemorial’ a male-centred and, until the 1990s, almost exclusively male intellectual tradition and professional practice – at least in the eyes of the currently dominating historiography. Helas, the ambition had to be downscaled into a few rapid zooms, touristic snapshots in an impressionistic mode, on seven contexts in time and space in a hasty timeline from the eighteenth century to 2021. They reflect, merely as examples, women’s status in international law in diverse political, social and legal transformations or crisis. Some are representing moments of codification or the break-through of certain interpretations of women’s rights. Others are selected for their role in enabling women’s participation in decision-making or entry to international legal positions, or because they provide an example of women’s international activism for women’s rights. All of them might have preceded, followed, or in fact themselves constituted ‘Grotian Moments’ for ‘women’s rights’ – did they, and if not, why? Should they have? If yes, which ones and how, to what effect for ‘women’?
Pollen morphology and its taxonomic significance in Iranian Colchicum (Colchicaceae)
Authors: VAHDATI FATEMEH BAZDID , Beygom Faghir Marzieh , ASSADI MOSTAFA
Published: August 2023

Pollen morphology of 15 species of Colchicum was studied using light microscopy (LM) and scanning electron microscopy (SEM). The results revealed considerable pollen character variation among the studied species, which provides helpful data for species delimitation in Colchicum. The pollen grains are monad, bilateral symmetrical, isopolar to subisopolar, prolate, perprolate, subprolate and oblate spheroidal and medium to large in size. The outline of pollen grains varies from circular to tetragonal from polar view and elliptical from equatorial view; it is dicolpate, tetrazonoporate or diporate. The results showed five types of sexine ornamentation. The current study demonstrates that the pollen morphological characters are significant in taxonomic classification of the Colchicum and provide valuable information for species identification. We performed multivariate analysis to assess the possible contribution of palynological data to the species relationships. The results of cluster and principal component analysis demonstrated a close relationship among the studied species.
Cyrtomium remotipinnum (Dryopteridaceae), a new species from karst area in Guangxi, China
Authors: NONG SU-YUN , LIU YAN , YAN KE-JIAN , WEI HONG-JIN
Published: August 2023

Cyrtomium remotipinnum, a new species of Dryopteridaceae from the karst areas in Guangxi, China, is described and illustrated. The new species is distinguished from the two most similar species, C. calcis and C. pachyphyllum, by its larger stature and higher length-to-width ratio of pinnae. The new species is classified as Critically Endangered (CR) following IUCN Red List Criteria. In addition, this study attempted to identify some easily confused Cyrtomium species by combining venation patterns and soral distributions with other characters.
Helminthosporium paraoligosporum sp. nov., a new ascomycetous fungus from Ontario, Canada
Authors: ILYUKHIN EVGENY , MARKOVSKAJA SVETLANA
Published: August 2023

A novel anamorphic ascomycetous fungus, Helminthosporium paraoligosporum (Pleosporales, Ascomycota), isolated from branches of linden trees is described and characterized. The species is morphologically distinct from other Helminthosporium spp. by shorter conidiophores and conidia, and culture characteristics. Phylogenetic analysis of a combined set of ITS and LSU sequence data also supports the establishment of a new species. H. paraoligosporum is clustered with H. caespitosum, H. oligosporum, and H. tiliae. The species in this clade have similar morphological characteristics and host affiliation. In particular, conidiophores of the species (except H. tiliae) can be reduced to elongated conidiogenous cells. H. caespitosum is associated with Betula spp., while the other species in this clade have been collected from Tilia spp. only.
First records of cave-dwelling pseudoscorpions of the genus Ephippiochthonius Beier, 1930 (Arachnida: Pseudoscorpiones: Chthoniidae) from the Caucasus, with description of three new species from Abkhazia and taxonomic comments on the genus
Authors: TURBANOV ILYA S. , KOLESNIKOV VASILIY B.
Published: August 2023

Three new hypogean Ephippiochthonius species from karst caves of Abkhazia (Western Caucasus) are described, including detailed diagnoses and illustrations: Ephippiochthonius kovali sp. nov., E. vargovitshi sp. nov. and E. dbari sp. nov. These are the first cave-dwelling species of the genus described from the Caucasus. The taxonomic significance of the position of the intermediate setae ih3 and ih4 on the antiaxial side of chelal hand in the genus Ephippiochthonius is discussed. Based on this and other features, the heterogeneity of the tetrachelatus-group is demonstrated. Given the presence of seta ph3, the following new combinations are proposed for the species formerly assigned to Ephippiochthonius: Occidenchthonius kemza (Ćurčić, Lee et Makarov, 1993) comb. nov. from Pecina u Kozuvarskoj Glami Cave, Serbia and Occidenchthonius romanicus (Beier, 1935) comb. nov. from Comana, Romania (all ex Ephippiochthonius).
Heth longquani sp. n.—(Rhigonematomorpha: Hethidae)—obligate commensalistic nematode of camballoid millipede (Spirostreptida: Cambalopsidae) from Viet Nam
Authors: SPIRIDONOV SERGEI E. , ĐINH DUNG THE
Published: August 2023

A new nematode species, Heth longquani sp. n. (Hethidae, Ransonematoidea, Rhigonematomorpha, Rhabditida) is described from the camballoid millipede, Chonecambala crassicauda from Thanh Hóa province, Viet Nam. The morphological features of this new species were studied with brightfield and scanning electron microscopies. Partial sequences of LSU rDNA and Cox1 mtDNA are provided. The phylogeny of the nematodes of the genus Heth Cobb, 1898 is discussed.
The description of five new species of the genus Pantolyta (Hymenoptera, Diapriidae) from Africa
Authors: CHEMYREVA VASILISA G. , KOLYADA VICTOR A.
Published: August 2023

The genus Pantolyta is recorded for the first time from Africa. Five new species: Pantolyta gabonica sp.n., P. mostovskii sp.n., P. natalensis sp.n., P. noorti sp.n., and P. platycephala sp.n. are described from South Africa and Gabon. All species are keyed and illustrated.
Description of the first brachypterous Lonchidia species (Hymenoptera: Figitidae: Figitinae), with a key to European species
Authors: PAZ VÍCTOR DE , BAÑOS-PICÓN LAURA , ROSAS-RAMOS NATALIA , ASÍS JOSEP D. , LOBATO-VILA IRENE , PUJADE-VILLAR JULI
Published: August 2023

The male and female of a new species of Lonchidia Thomson, 1862, L. atypica Pujade-Villar & de Paz sp. nov., are described from the provinces of Salamanca and Cáceres (Western Spain). Specimens were collected with a G-Vac suction sampler and pitfall traps from traditional almond and cherry orchards. The diagnostic characters of this species are: deep but short notauli, reaching only the anterior part of the mesoscutum, and brachypterous wings. Both sexes are illustrated and an identification key is proposed herein to differentiate the European species. The possibility that the male of L. clavicornis Thomson, 1862 corresponds to a different species is also discussed.
Neotrichia anamariae sp. nov.: The first record of Neotrichia Morton 1905 (Trichoptera: Hydroptilidae) from Maranhão State, Northeast Brazil
Authors: NETO JAIME DE LIEGE GAMA , PASSOS MAHEDY ARAUJO BASTOS
Published: August 2023

The male and female of Neotrichia anamariae sp. nov., a new species of Neotrichia from Northeast Brazil Region, are described and illustrated, representing the first record of Neotrichia from Maranhão State.
Preparation of Molecularly Imprinted Hydrogel Contact Lenses for Extended Atropine Eluting
Authors: Wang Zhao , Li Ting , Li Xinhua , Wu Haitao , Li Yuhang , Hao Lingyun
Published: August 2023

The prevalence of myopia is becoming the primary public health issue globally. Low-concentration atropine showed a significant effect in controlling myopia progression. However, the dosage form of eye drops presents <5% ocular bioavailability and burst release. In this work, a series
of molecularly imprinted hydrogel (MIP) contact lenses with different functional comonomers were prepared for atropine delivery, with non-imprinted hydrogel (NIP) contact lenses being fabricated for control. Key contact lens properties (including light transmission, water content, and surface
wettability) and drug loading/release behavior were evaluated. According to our results, specific MIP adsorption onto atropine promoted drug loading capability while regulating drug release in contact lenses. By using methacrylic acid (MAA) and methacrylamide (MAm) to be the functional comonomers,
the imprinted hydrogel (MIP-2) was most affiliative for atropine, which could delay in vitro drug release time up to 72 h, without affecting key properties of contact lenses. The cytotoxicity study indicated the good biocompatibility of MIPs, revealing their great potential as efficient
ocular drug delivery systems for myopia control.
CD5L is a Potential Biomarker for Clinical Prognosis and Immunotherapy of Hepatocellular Carcinoma
Authors: Zhang Baojian , Ma Xiao , Lin Zhenhua , Liu Yanqun
Published: August 2023

The CD5L molecule (CD5L), also known as macrophage apoptosis inhibitor (AIM), has multiple functions in lipid metabolism and inflammatory processes. However, there is a lack of evaluation of CD5L in human tumors, especially its predictive role in HCC progression. The expression of CD5LmRNA
in patients with hepatocellular Carcinoma was searched by The Tumor Genome Atlas (TCGA) database. CD5L had significant protein interactions with FASN, CD163, STAB2, and LILRB5, which were retrieved by the timer database. The relationship between CD5L survival and prognosis in HCC and hepatitis
was analyzed by the KaplanMeier database. CD5L enrichment was analyzed by KEGG, Biological processes, Molecular functions, and Cellular components. CD5L expression was low in tumor tissues and high in neighboring tissues, showing a tumor inhibitory effect. Low expression of CD5L in patients
with hepatitis is associated with poor prognosis. TP53 mutations with low CD5L expression accounted for a high proportion of HCC. The high expression of CD5L promotes the infiltration of CD4+ T cells, CD8+ T cells, macrophages, Tfh, and other cells, causing an immune response. We comprehensively
evaluated the role of CD5L biomarkers in HCC, and CD5L may be a new target for tumor immunotherapy.
Effect of Different Applied Torque Maintenance Times on Detorque Values of Abutment Screws in Single Implant-Supported Fixed Prostheses
Authors: Alotaibi Hanan , Alnamlah Sarah , Almazroa Rana , Alfouzan Afnan , Altaweel Sara , Alshehri Huda , Labban Nawaf
Published: August 2023

We evaluated the effect of maintaining the applied torque for one minute on the reverse torque value (RTV) as compared to immediate torque application and retorquing after 10 minutes. A total of 48 screws were used to torque the abutment utilizing three different protocols (A–C);
immediate torque application to the recommended 35 Ncm, torque applied to the recommended 35 Ncm, followed by retorquing of the same screw after 10 minutes and abutment screws were torqued to the recommended 35 Ncm, and the torque was held for one minute. The gap size between the implant and
supra-structure was measured at three fixed points for each surface. Data were analyzed using SPSS software (α = 0.05). The mean RTV for 1 minute, immediate, and 10 minutes was 32.68±2.04 Ncm, 32.5±0.93 Ncm, and 30.54±0.90 Ncm, respectively. The difference
between RTV in the 1-min and 10-min protocols was significant (P <0.05). Pearson’s coefficient demonstrated a negative correlation between RTV and the gap between the supra-structure and the implant interface (r =−0.43, P <0.01). When tightening abutment
screws of implant-supported single crowns, holding the applied torque for 1 minute has proven to be efficient. Furthermore, larger gap values between the supra-structure and the implant inversely affect RTV, forcing the clinician to take caution to have a well-fitted supra-structure with as
minimal a gap as possible.
Groundwater Feedbacks on Climate Change in the CNRM Global Climate Model
Authors: Colin Jeanne , Decharme Bertrand , Cattiaux Julien , Saint-Martin David
Published: August 2023

Groundwater and climate interact in a two-way manner. Precipitation ultimately controls groundwater recharge and, conversely, groundwater may influence climate through evapotranspiration. Yet very few global climate models or Earth system models actually simulate groundwater flows. And while the expected impacts of climate change on groundwater resources are the subject of a growing concern, global-scale groundwater–climate feedbacks have received very little attention so far. Here we show that the integration of unconfined aquifers in a global climate model can regionally affect the climate change signal on temperatures and precipitation. We assess the impact of groundwater under preindustrial and 4xCO2 conditions (after climate stabilization). In both cases, we find that groundwater has a cooling and a wetting effect in certain regions of the world. In eastern Europe, both these impacts are stronger in the warmer climate (4xCO2 forcing) where the presence of groundwater reduces the frequency of summer heatwaves by 40%, compared to a 15% reduction in the preindustrial world. This work constitutes one of the very first global assessments of the potential feedbacks of groundwater on climate change. Our results support the idea that groundwater should be represented in global climate models and Earth system models, as it does indeed play an active role in the climate system.
“A Completely Different World”: A Counterstory of Transfronterizx Experiences
Authors: Gerrard Crystal Lynn , Rey
Published: August 2023

This article provides a counterstory to damaging, dominant narratives concerning migrant experiences and border crossings. Through counter-storytelling, I share Rey’s lived experiences as a transfronterizx (transborder) student who crossed the United States–Mexico border daily to attend school and eventually, participate in school music. The overarching question guiding the study was: What are a transfronterizx student’s experiences navigating school and school music in the United States? Based on the findings, Rey encountered literal and metaphorical barriers as he pursued an education in the United States. In particular, navigating language, deficit-based teaching practices, surveillance, and policing were key in his narrative. Currently as a music educator, Rey draws from his personal transfronterizx background to inform his music teaching practices in a predominantly Latine school community. Considerations for working with migrant students and families are discussed in light of ongoing sociopolitical issues, including the need for more culturally and linguistically responsive practices.
Coda and Catharsis: Exploring the Emotional Challenges and Coping of Junior Palliative Physicians Through Cinematic Reflection
Authors: Koh Li Yen Tessa , Yung Sek Hwee , Chia Siew Chin , Chia T-Yunn , Koh Yong Hwang Mervyn , Patinadan Paul Victor , Wong Teck Yee
Published: August 2023

Background: There has been little research on reflective tools for junior doctors, whom may have encountered challenges working in palliative care whereby grief and losses are high. This is a qualitative study aiming to firstly explore the emotional challenges of junior doctors and secondly whether the movie is an effective reflective tool. Setting/participants: 32 junior doctors rotating through the palliative care unit were recruited and underwent a combined movie screening with a focus group discussion after. Results: Emotional challenges highlighted were (1) lifting the veil of death (2) impeded call of action (3) manifesting inner fatigue. Majority found the movie relatable to their clinical practice and felt that the focus group discussion was helpful. Conclusion: Junior doctors do have certain emotional challenges during their palliative care posting. Having a movie session combined with a focus group discussion is a reasonable method to help them reflect about their challenges.
Growing Up in Adversity: A Moderated Mediation Model of Family Conflict, Cyberbullying Perpetration, Making Sense of Adversity and Depression
Authors: Jiang Chaoxin , Jiang Shan
Published: August 2023

Although family conflict is recognized as a detrimental factor for adolescents’ depression, the underlying mechanisms remain unknown. This study investigates the mediating effect of cyberbullying perpetration and the moderating effect of making sense of adversity in this association. A sample of 814 Chinese adolescents (Mean age = 16.79 years) from Zhejiang province, China, is collected through multi-stage cluster random sampling. The moderated mediation model is performed by SPSS macro PROCESS. The results illustrate that cyberbullying perpetration partially mediates the relationship between family conflict and depression. In addition, the effects of family conflict on cyberbullying perpetration and depression are moderated by making sense of adversity, with the impact being weaker for adolescents with high making sense of adversity than for those with low making sense of adversity. These findings contribute to our understanding of the influencing path from family conflict to depression, as well as the significance of making sense of adversity in Chinese culture. The need for policy development and family intervention to improve adolescents’ mental health are emphasized.
The fall of a city: Refugees, exodus and exile in Ernest Hemingway’s Istanbul, 1922
Authors: Maksudyan Nazan
Published: August 2023

Ernest Hemingway arrived in Istanbul on 30 September 1922 to cover the end of the Greek–Turkish War for the Toronto Star. From late October to mid-November 1922, Hemingway wrote 20 articles about the last days of the war and the re-constellation of political legitimacy in the region. There are four distinguishing features of Hemingway’s reports from Constantinople. First, they provided an eloquent depiction of the city, suggesting the charm and squalor of old ‘Constan’ for the young writer. The second was a clear expectation of a ‘second disaster’, which was assumed to be a replica of Smyrna. Hemingway clearly observed the fears of non-Muslims and foreigners in the city, who were panicking over possible new massacres and pillage. Third, Hemingway quickly realized that the exodus of people – the desperate flight of Christian refugees – and Turkification of the country would be his main subject. His repeated emphasis on refugees permanent loss of a home is reminiscent of Hannah Arendt’s famous essay ‘We Refugees’, as well as a precursor to Agamben’s point that refugees are reduced to ‘bare life’. Lastly, his prose relied on irony and cynicism, as a cover for his disappointment and shame for humanity and modern civilization. Juxtaposing his writing with contemporary local accounts, I intend to situate his witnessing into the larger historiography of ‘Armistice Istanbul’ and the homogenization policies of the winning Turkish nationalist leadership. Hemingway’s critique of (homogeneous) nation-state formation after the war and the favourable involvement of the Allied countries and humanitarian agencies in the mass production of refugees was quite exceptional and ahead of his times.
Israel’s priority in Old Testament missiology
Authors: Cornell Collin
Published: August 2023

The present article challenges Walter C. Kaiser, Jr’s influential proposal for evangelical Old Testament missiology. Out of concern to avoid an understanding of “Israel as God’s favored or pet nation,” Kaiser argues that God’s promise to Abraham in Gen 12:3 is for the sake of all nations, and as such, “the first Great Commission mandate of the Bible.” In its three exegetical sections, the article seeks to overturn Kaiser’s Gentile-centric interpretation of the apostle Paul; his reading of the Primeval History in Genesis as a story of universal curse; and his understanding of the blessing of Abraham as remedial. More basically, it asserts the priority of Israel within God’s ways and works.
Customary Mortgages and the Moral Economy of Kinship in Chinese Lineage Villages, 1905–1965
Authors: Chan Kwok-shing
Published: August 2023

This article illustrates the development and characteristics of two customary forms of mortgage lending by analyzing a total of 3,630 mortgage cases found in four lineage communities in rural Hong Kong during the period 1905–1965 under British colonial rule. Two major findings are presented. First, there was a progressive decline of the dian 典 form, in sharp contrast to the increasing popularity of the diya 抵押 form. Second, while dian practices distinctly followed prevailing kinship-based moral values and obligations to help needy agnates, agnatic ties were not a significant factor in determining the terms of diya loans. This suggests that needy villagers did not feel disinclined to get a loan from lineage outsiders who could offer reasonable or attractive terms. The popularity of the diya practice demonstrates the existence of a strategic balance between self-interest and communal moral values and mutual obligations in lineage communities.
The BETTER Traumatic Brain Injury Transitional Care Intervention: A Feasibility Study
Authors: Oyesanya Tolu O. , Loflin Callan , You HyunBin , Myers John , Kandel Melissa , Johnson Karen , Strauman Timothy , Hawes Jodi , Byom Lindsey , Gonzalez-Guarda Rosa , Van Houtven Courtney , Agarwal Suresh , Prvu Bettger Janet
Published: August 2023

This study aimed to investigate the feasibility, acceptability, and clinical outcome measures of BETTER (Brain Injury Education, Training, and Therapy to Enhance Recovery), a culturally tailored traumatic brain injury (TBI) transitional care intervention, among diverse younger adult patients with TBI (age 18-64) and their caregivers. Trained clinical interventionists addressed patient/family needs; established goals; coordinated post-hospital care and resources; and provided patient/family training on self- and family-management coping skills. Fifteen dyads enrolled ( N = 31, 15 patients, 16 caregivers). All completed baseline data; 74.2% ( n = 23; 10 patients, 13 caregivers) completed 8-week data; 83.8% ( n = 26; 13 each) completed 16-week data. Approximately 38% ( n = 12, 3 patients, 9 caregivers) completed acceptability data, showing positive experiences (mea n = 9.25, range 0-10; SD = 2.01). Overall and mental quality of life (QOL) scores did not differ over time but physical QOL scores did improve over time (baseline: 30.3, 8 weeks: 46.5, 16 weeks: 61.6; p = 0.0056), which was considered to be a suitable outcome measure for a future trial. BETTER is a promising intervention with implications to improve TBI care standards. Research is needed to determine efficacy in a randomized trial.
Mitral valve repair in patients with mirror-image dextrocardia and situs inversus: two cases and a review of the literature
Authors: Nie Jun , Tang Tiansheng , Wang Ziao , Zhang Dafa , Wei Jun , Sheng Weiyong
Published: August 2023

Dextrocardia is a rare cardiac malposition that was first described in 1606. Mirror-image dextrocardia is characterized by a mirror-image change of the normal position of the heart. Most cases are accompanied by situs inversus viscerum, whereas only 3% to 10% of cases are associated with intracardiac anomalies. Valve surgery for acquired valvular lesions in patients with mirror-image dextrocardia with situs inversus is rare. Diagnosing situs anomalies in adults is important to prevent errors during surgical operations, emergency procedures, or interventional operations. In this report, we present two cases of mitral regurgitation in patients with mirror-image dextrocardia. One patient had mirror-image dextrocardia with subacute infective endocarditis and mitral regurgitation, and the other patient had mirror-image dextrocardia with mitral Carpentier type I regurgitation. In both patients, mitral valve repair was successfully performed using a transseptal approach.
Evaluating Shared Taxis in Rural Areas from the Perspective of Number of Drivers
Authors: Feng Wenhao , Tanimoto Keishi , Fujimoto Takashi
Published: August 2023

Public transportation is inconvenient in many rural areas, and the number of its users is small. However, for people who cannot drive, such as the elderly, public transportation is necessary. Therefore, public transportation needs to be maintained even if the demand is low. Although various alternatives are available, the taxi is the most suitable form of public transportation for low-demand areas. However, because of a decline in passengers and a shortage of drivers, the taxi business environment is challenging, and its sustainability is in danger. One effective solution for driver shortage is to introduce shared taxis, but its necessity decreases as the number of passengers continues to decline. Based on these factors, taxi operators have to select the mode of transportation between shared and traditional taxis. If there is a method to evaluate shared taxis compared with traditional taxis, it will be useful in mode selection. In this study, we propose a method for evaluating shared taxis based on the perspective that the lower the minimum number of drivers needed for operation, the better the sustainability of taxi operators. Specifically, using mixed integer programming, we formulate a mathematical programming model that can compute the minimum number of drivers needed, and construct an approach to evaluate shared taxis using statistical models estimated from the results calculated by the mathematical programming model. Then, we demonstrate the effectiveness of this approach through a case study.
Prospective Randomized Clinical Trial of Arthroscopic Repair Versus Debridement for Partial Subscapularis Tendon Tears More Than Half of the Entire First Facet
Authors: Jeong Jeung Yeol , Kim Su Cheol , Lee Sang Min , Yoo Jae Chul
Published: August 2023

Background:

Most outcome studies on subscapularis (SSC) tendon tears have focused on large SSC tears rather than partial SSC tendon tears. Therefore, the optimal treatment for partial SSC tendon tears more than half of the first facet of the entire SSC footprint has not yet been clearly defined.

Purpose:

To prospectively investigate the clinical and radiological results between the arthroscopic repair group and the debridement group in SSC partial tear (Yoo and Rhee classification, type 2B: SSC tendon tears of more than half of the entire first facet).

Study Design:

Randomized controlled trial; Level of evidence, 1.

Methods:

A total of 65 patients with SSC tendon type 2B tears were randomized to arthroscopic debridement (n = 33) or arthroscopic repair (n = 32). Clinical evaluation of the patients was performed on the day before surgery and 6 months, 1 year, 2 years, and 5 years postoperatively using active range of motion measurements and other validated scores (pain visual analog scale scores, function visual analog scale scores, Constant score, American Shoulder and Elbow Surgeons score). In addition, SSC muscle strength was measured using instruments in the belly-press position. Magnetic resonance imaging (upper and lower SSC muscle diameters, Goutallier grades) was performed on the day before operation as well as 6 months and 2 years postoperatively.

Results:

There were no clinically or statistically significant differences between the arthroscopic debridement and arthroscopic repair groups with respect to active range of motion, pain visual analog scale scores, function visual analog scale scores, Constant scores, or American Shoulder and Elbow Surgeons scores. There was a statistically significant increase in SSC muscle strength in the repair group compared with the debridement group at 5 years postoperatively ( P = .013). Magnetic resonance imaging assessment was also not significantly different between the 2 groups.

Conclusion:

There were no differences in the patient-reported outcomes of patients with partial SSC tears treated with either arthroscopic debridement or repair, although there was an increase in SSC muscle strength associated with repair, the clinical importance of which may warrant further research.

Registration:

NCT03183466 (ClinicalTrials.gov identifier).