bluuebunny/crossref_metadata_2025 huggingface dataset:
Planning and Construction Strategies for Infrastructure in Traditional Villages of the Grand Canal from the Perspective of Villager Needs
Authors: Zhou Haijun , Chang Jiang
Published: November 2024

The traditional villages along the Jiangsu section of the Grand Canal are facing the threat of decline and disappearance due to the decline of the canal transportation function and the advancement of urbanization, and it is urgent to study the protection and renewal of these villages. Based on the needs of villagers, this study aims to explore the planning and construction strategies of traditional village infrastructure in the Jiangsu section of the Grand Canal. Through a literature review, field investigation, and qualitative and quantitative analysis methods, this paper conducts in-depth research and data analysis on the status quo of six types of infrastructure in 29 traditional villages, including road traffic, water supply and drainage, garbage sanitation, energy utilization, postal communication, and ecological disaster prevention. The research results show that, although the infrastructure construction has made some progress, there are still problems such as unreasonable planning, low construction quality, and the lack of cultural characteristics, which cannot fully meet the actual needs of villagers. Through a regional comparative analysis, it is found that the infrastructure condition of the Jiangnan Canal section is better than that of the Huaiyang Canal section and Middle Canal section, but they all face challenges of protection and renewal. Based on the needs of villagers, this study puts forward corresponding protection and optimization strategies, which provide theoretical guidance and practical methods for the sustainable development of traditional village infrastructure, and it has important reference significance for the infrastructure protection and development of traditional villages in other regions.
Study on the Influence of the Built Environment and Personal Attributes on Commuting Distance: A Case Study of the Tianjin Central Area Divided by TAZ Units
Authors: Zhou Jiayin , Xin Jingyi , Meng Lingxin , Tan Lifeng
Published: November 2024

Long commuting distances pose a significant challenge for many large cities, undermining the principles of sustainable urban development. The factors influencing urban commuting distances among residents are complex and necessitate hierarchical analysis. This study uses Tianjin, one of China’s four municipalities, as a case study, employing transportation analysis zones (TAZ) as research units. We classify these units based on resident and working populations, extracting multiple built environment and personal attribute factors to establish a model that examines the influence of the job–housing balance. The analysis identifies 12 sub-items across two categories of influencing factors, with correlations tested through spatial analysis and linear regression. We found 28 positive associations and 35 negative associations. Notably, the job–housing relationship for the working population was generally more sensitive to changes than that of the resident population. At the TAZ level, personal attributes exerted a more significant influence on the job–housing balance than built environment factors, with commuting mode, life stage, age, and income level notably affecting commuting distances.
Relationship Between Loss of Y Chromosome and Urologic Cancers: New Future Perspectives
Authors: Russo Pierluigi , Bizzarri Francesco Pio , Filomena Giovanni Battista , Marino Filippo , Iacovelli Roberto , Ciccarese Chiara , Boccuto Luigi , Ragonese Mauro , Gavi Filippo , Rossi Francesco , Savoia Cosimo , Suraci Paolo Pietro , Falabella Roberto , Pandolfo Savio Domenico , Napolitano Luigi , Leoni Chiara , Trevisan Valentina , Palermo Giuseppe , Racioppi Marco , Sacco Emilio , Muselaers Stijn , Foschi Nazario
Published: November 2024

Background: The Y chromosome (ChrY) is essential for male sex determination and spermatogenesis. However, recent studies have revealed its broader role in various physiological processes and disease susceptibility, including cancer. Methods: A comprehensive literature review was conducted using databases like MEDLINE, Scopus, Web of Science, and Google Scholar. The review included clinical and preclinical studies in animals and humans focusing on the role of LoY in urological tumors. Data on the frequency of LoY, its clinical implications, and underlying mechanisms were extracted and analyzed. Results: The evidence suggests that LoY is associated with an increased risk of urologic neoplasms, potentially serving as an early marker of genomic instability. Studies reveal that LoY in urologic cancers correlates with worse survival outcomes and may contribute to tumor progression. LoY may interfere with chromatin structure and epigenetic regulation, suggesting its role as a contributor to early tumorigenesis. Conclusions: LoY appears to be a structural aberration with unique biological and clinical relevance in urologic cancers, possibly serving as a biomarker for genomic instability. Further research is necessary to identify specific Y-linked genes affected by LoY, potentially informing targeted therapies and early diagnostic strategies for these cancers.
Effect of Plasma Treatment on Self-Cleaning Features of Acrylic Paint/TiO2-Coated Surfaces for Environmental Pollutant Removal
Authors: Bilić Andrijana , Armaković Sanja J. , Šiljegović Mirjana V. , Kisić Milica , Šćepanović Maja , Grujić-Brojčin Mirjana , Simić Nataša , Gavanski Lazar , Armaković Stevan , Savanović Maria M.
Published: November 2024

This study investigates the characterization and performance of self-cleaning TiO2 surfaces synthesized through a one-step preparation process, followed by enhancement via plasma treatment. The process involved coating aluminum foil with an acrylic paint mixture containing nanoparticles of different mass compositions and subsequent plasma treatment using a continuous plasma arc. Scanning electron microscopy revealed the morphology of the treated surfaces, showing an increase in surface area of plasma-treated materials. Energy-dispersive X-ray spectroscopy revealed changes in oxygen and titanium in acrylic paint/TiO2 surfaces as the TiO2 content increased, indicating successful TiO2 incorporation. Raman spectroscopy showed that the bulk structure of self-cleaning acrylic paints is mainly preserved after plasma treatment. Alternating current impedance spectroscopy assessed that plasma treatment reduced agglomeration and increased active sites, especially for the acrylic paint/TiO2 surfaces with 0.5 mg/cm3 TiO2. The contact angle measurements indicated that plasma treatment enhanced the superhydrophobic characteristics and potential self-cleaning abilities of produced acrylic paint/TiO2 surfaces. The efficacy of these plasma-treated surfaces in self-cleaning was evaluated by testing their performance against puddle sediment and automotive oil samples. The study demonstrated that plasma treatment positively impacted the self-cleaning ability of the acrylic paint/TiO2 surfaces, particularly those with 0.5 mg/cm3 TiO2. This enhancement was attributed to the formation of functional groups, improved water repellency, and possible increases in surface area, which collectively contribute to the sustainable self-cleaning properties of the treated surfaces.
In Situ SERS Monitoring of Schiff Base Reactions via Nanoparticles on a Mirror Platform
Authors: Chen Binbin , Meng Shiyong , Liu Danmin , Deng Qingsong , Wang Cong
Published: November 2024

Schiff base reactions are widely used in pharmacy, catalysis, and volatile aldehyde detection. However, common biomarker sensing methods struggle to monitor this reaction process precisely due to their sensitivity, their time-consuming nature, and complex substrates. Here, we introduce the Nanoparticle-on-Mirror structure for in situ monitoring this reaction process through the application of a Au nanoparticle-p-Aminothiophenol-Au thin-film platform by surface-enhanced Raman scattering (SERS). Owing to the exposure of -NH2 groups and the local ultra-strong electromagnetic field in the nanocavity, the Schiff base reactions process can be rapidly monitored within two minutes. Meanwhile, the monitoring platform can detect benzaldehyde molecules as low as 10−6 M, showing excellent SERS performance. Notably, the Au-nanoparticle-p-Aminothiophenol-Au thin-film platform exhibited anti-interference and specificity, being able to identify BA in the presence of interference. The use of the Au-nanoparticle-p-Aminothiophenol-Au thin-film platform provides a sensing method for Schiff base reactions with accuracy and simplicity of operation, achieving a balanced approach for low-cost and high-performance real-time monitoring, which is expected to be applied in various catalytic reaction process monitoring and catalyst design processes.
DNA Methylation and Histone Acetylation Contribute to the Maintenance of LTP in the Withdrawal Behavior Interneurons in Terrestrial Snails
Authors: Zuzina Alena , Kolotova Daria , Balaban Pavel
Published: November 2024

Accumulated data indicate that epigenetic regulations, including histone modifications and DNA methylation, are important means for adjusting the expression of genes in response to various stimuli. In contrast to the success in studying the role of DNA methylation in laboratory rodents, the role of DNA methylation in the terrestrial snail Helix lucorum has been studied only in behavioral experiments. This prompted us to further investigate the role of DNA methylation and the interaction between DNA methylation and histone acetylation in the mechanisms of neuroplasticity in terrestrial snails using in vitro experiments. Dysregulation of DNA methylation by the DNMT inhibitor RG108 significantly suppressed the long-term potentiation (LTP) of synaptic inputs in identified neurons. We then tested whether the RG108-induced weakening of potentiation can be reversed under co-application of histone deacetylase inhibitors sodium butyrate or trichostatin A. It was found that increased histone acetylation significantly compensated for RG108-induced LTP deficiency. These data bring important insights into the functional role of DNA methylation as an important regulatory mechanism and a necessary condition for the development and maintenance of long-term synaptic changes in withdrawal interneurons of terrestrial snails. Moreover, these results support the idea of the interaction of DNA methylation and histone acetylation in the epigenetic regulation of synaptic plasticity.
18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Large-Vessel Vasculitis During Active and Inactive Disease Stages Is Associated with the Metabolic Profile, but Not the Macrophage-Related Cytokines: A Proof-of-Concept Study
Authors: Palamidas Dimitris Anastasios , Kalykakis Georgios , Benaki Dimitra , Chatzis Loukas , Argyropoulou Ourania D. , Palla Panagiota , Kollia Antonia , Kafouris Pavlos , Metaxas Marinos , Goules Andreas V. , Mikros Emmanuel , Kambas Konstantinos , Anagnostopoulos Constantinos D. , Tzioufas Athanasios G.
Published: November 2024

Giant cell arteritis (GCA) is an autoimmune/autoinflammatory disease affecting large vessels in patients over 50 years old. The disease presents as an acute inflammatory response with two phenotypes, cranial GCA and large-vessel vasculitis (LV)-GCA, involving the thoracic aorta and its branches. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET-CT) is among the imaging techniques contributing to diagnosing patients with systemic disease. However, its association with soluble inflammatory markers is still elusive. This proof-of-concept study aims to identify novel soluble serum biomarkers in PET/CT-positive patients with LV-GCA and associate them with active (0 months) and inactive disease (6 months following treatment), in sequential samples. The most-diseased-segment target-to-background ratio (TBRMDS) was calculated for 13 LV-GCA patients, while 14 cranial GCA and 14 Polymyalgia Rheumatica patients with negative initial PET/CT scans served as disease controls. Serum macrophage-related cytokines were evaluated by cytometric bead array (CBA). Finally, previously published NMR/metabolomics data acquired from the same blood sampling were analyzed along with PET/CT findings. TBRMDS was significantly increased in active versus inactive disease (3.32 vs. 2.65, p = 0.006). The analysis identified nine serum metabolites as more sensitive to change from the active to inactive state. Among them, choline levels were exclusively altered in the LV-GCA group but not in the disease controls. Cytokine levels were not associated with PET/CT activity. Combining CRP, ESR, and TBRMDS with choline levels, a composite index was generated to distinguish active and inactive LV-GCA (20.4 vs. 11.62, p = 0.001). These preliminary results could pave the way for more extensive studies integrating serum metabolomic parameters with PET/CT imaging data to extract sensitive composite disease indexes useful for everyday clinical practice.
Dysregulation of miRNAs in Soft Tissue Sarcomas
Authors: Zoroddu Stefano , Lucariello Angela , De Luca Antonio , Bagella Luigi
Published: November 2024

MicroRNAs (miRNAs) are pivotal regulators of gene expression, influencing key cellular processes such as proliferation, differentiation, apoptosis, and metastasis. In the realm of sarcomas—a diverse group of malignant tumors affecting soft tissues and bone sarcomas—miRNAs have emerged as crucial players in tumorigenesis and tumor progression. This review delves into the intricate roles of miRNAs across various soft tissue sarcoma subtypes, including rhabdomyosarcoma, liposarcoma, leiomyosarcoma, synovial sarcoma, fibrosarcoma, angiosarcoma, undifferentiated pleomorphic sarcoma (UPS), and malignant peripheral nerve sheath tumor (MPNST). We explore how dysregulated miRNAs function as oncogenes or tumor suppressors, modulating critical pathways that define the aggressive nature of these cancers. Furthermore, we discuss the diagnostic and prognostic potential of specific miRNAs and highlight their promise as therapeutic targets. By understanding the miRNA-mediated regulatory networks, this review aims to provide a comprehensive overview of current research while pointing towards future directions for miRNA-based therapies. Our findings underscore the potential of miRNAs to transform the landscape of sarcoma treatment, offering hope for more precise, personalized, and effective therapeutic strategies.
GPS-pPLM: A Language Model for Prediction of Prokaryotic Phosphorylation Sites
Authors: Zhang Chi , Tang Dachao , Han Cheng , Gou Yujie , Chen Miaomiao , Huang Xinhe , Liu Dan , Zhao Miaoying , Xiao Leming , Xiao Qiang , Peng Di , Xue Yu
Published: November 2024

In the prokaryotic kingdom, protein phosphorylation serves as one of the most important posttranslational modifications (PTMs) and is involved in orchestrating a broad spectrum of biological processes. Here, we report an updated online server named the group-based prediction system for prokaryotic phosphorylation language model (GPS-pPLM), used for predicting phosphorylation sites (p-sites) in prokaryotes. For model training, two deep learning methods, a transformer and a deep neural network, were employed, and a total of 10 sequence features and contextual features were integrated. Using 44,839 nonredundant p-sites in 16,041 proteins from 95 prokaryotes, two general models for the prediction of O-phosphorylation and N-phosphorylation were first pretrained and then fine-tuned to construct 6 predictors specific for each phosphorylatable residue type as well as 134 species-specific predictors. Compared with other existing tools, the GPS-pPLM exhibits higher accuracy in predicting prokaryotic O-phosphorylation p-sites. Protein sequences in FASTA format or UniProt accession numbers can be submitted by users, and the predicted results are displayed in tabular form. In addition, we annotate the predicted p-sites with knowledge from 22 public resources, including experimental evidence, 3D structures, and disorder tendencies. The online service of the GPS-pPLM is freely accessible for academic research.
Tunable Optical Properties and Relaxor Behavior in Ni/Ba Co-Doped NaNbO3 Ceramics: Pathways Toward Multifunctional Applications
Authors: Chaabeni Tawfik , Benzarti Zohra , Abdelmoula Najmeddine , Zghal Slim
Published: November 2024

In this study, Ni/Ba co-doped NaNbO3 ceramics (NBNNOx) were synthesized using a solid-state method to explore the effects of Ni2+ and Ba2+ ion substitution on the structural, optical, and dielectric properties of NaNbO3. X-ray diffraction (XRD) confirmed that the ceramics retained an orthorhombic structure, with crystallinity improving as the doping content (x) increased. Significant lattice distortions induced by the Ni/Ba co-doping were observed, which were essential for preserving the perovskite structure. Raman spectroscopy revealed local structural distortions, influencing optical properties and promoting relaxor behavior. Diffuse reflectance measurements revealed a significant decrease in band gap energy from 3.34 eV for undoped NaNbO3 to 1.08 eV at x = 0.15, highlighting the impact of co-doping on band gap tunability. Dielectric measurements indicated relaxor-like behavior at room temperature for x = 0.15, characterized by frequency-dependent anomalies in permittivity and dielectric loss, likely due to ionic disorder and structural distortions. These findings demonstrate the potential of Ni/Ba co-doped NaNbO3 ceramics for lead-free perovskite solar cells and other functional devices, where tunable optical and dielectric properties are highly desirable.
Proportional Trends in Pediatric Opioid Prescribing Between 2005 and 2016 by Age Group, Sex, Ethnicity, Race, Language, and Payer Status from a Large Children’s Hospital in the Southwest United States
Authors: Pielech Melissa , Kruger Eric , Portis Samantha M. , Wilson Khirsten J. , Rivers W. Evan , Vowles Kevin E.
Published: November 2024

Background/Objectives: Prescription opioid use before adulthood is typically effective for acute pain control and is also associated with adverse short- and long-term consequences. Methods: This study examined pediatric opioid prescribing trends over time across different age groups (early childhood, school age, adolescence, young adult) and sociodemographic subgroups (sex, ethnicity, race, language, payer type) from 2005 to 2016. Results: Utilizing 42,020 first outpatient opioid prescriptions for youth aged 0–21 years from a large US children’s hospital, this research found notable trends and disparities. Prescription rates increased by 35% from 2005–2007 to 2008–2010, then decreased by 14% from 2008–2010 to 2011–2013, and decreased again by 22% from 2011–2013 to 2014–2016. Chi-squared tests indicated significant changes in prescription rates across all sociodemographic subgroups, though only age group, ethnicity, and payer type (i.e., the party responsible for payment for hospital services) had changes with non-negligible effect sizes (Cramer’s V). Specifically, age group showed small to medium effects (V = 0.16), while ethnicity and payer demonstrated small effects (V = 0.10 each). This study highlights variations in opioid prescribing trends, particularly among different age groups, ethnicities, and payer statuses up to 2016. Conclusions: These findings reveal differing trends in pediatric opioid prescribing during the peak of the opioid epidemic, highlighting the importance of considering age and sociodemographic variables for understanding prescribing patterns fully and raising potential concerns about inequities in pain management. Future studies should explore similar trends from 2016 onward.
Genetics and Molecular Pathogenesis of the Chondrosarcoma: A Review of the Literature
Authors: Iacobescu Georgian-Longin , Corlatescu Antonio-Daniel , Serban Bogdan , Spiridonica Razvan , Costin Horia Petre , Cirstoiu Catalin
Published: November 2024

The chondrosarcoma, a cartilage-forming bone tumor, presents significant clinical challenges due to its resistance to chemotherapy and radiotherapy. Surgical excision remains the primary treatment, but high-grade chondrosarcomas are prone to recurrence and metastasis, necessitating the identification of reliable biomarkers for diagnosis and prognosis. This review explores the genetic alterations and molecular pathways involved in chondrosarcoma pathogenesis. These markers show promise in distinguishing between benign enchondromas and malignant chondrosarcomas, assessing tumor aggressiveness, and guiding treatment. While these advancements offer hope for more personalized and targeted therapeutic strategies, further clinical validation of these biomarkers is essential to improve prognostic accuracy and patient outcomes in chondrosarcoma management.
Integrating Building- and Site-Specific and Generic Fragility Curves into Seismic Risk Assessment: A PRISMA-Based Analysis of Methodologies and Applications
Authors: Camayang Jhon Philip , Dela Cruz Orlean , Grutas Rhommel
Published: November 2024

Fragility curves are fundamental tools in seismic risk assessments, providing insights into the vulnerability of structures to earthquake-induced damages. These curves, which plot the probability of a structure reaching or exceeding various damage states against earthquake intensity, are critical for developing effective modification strategies. This review aims to present the characteristics between building- and site-specific fragility curves, which incorporate detailed local characteristics, and generic fragility curves that apply broader, more generalized parameters. We utilize the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) methodology to systematically review the literature to address key research questions about the methodological differences, applications, and implications of these curve types in assessing seismic risks. The methods involved a comprehensive search and combination of existing studies on the topic, focusing on how these curves are developed and applied in real-world scenarios. The results from this review show that building- and site-specific curves, while more precise, require extensive data and are therefore more complex and costly to develop. In contrast, generic curves, though less accurate, offer a cost-effective solution for preliminary risk assessments over large areas. The conclusions drawn from this review suggest that while each type has its merits, the choice between building- and site-specific and generic fragility curves should be guided by the specific requirements of the seismic risk assessment task, including available resources and the need for precision in the vulnerability estimations.
The Impact of Marine Heatwaves on Isotherm Displacement and Tuna Distribution in Vanuatu
Authors: Weinberg Hannah , Bhardwaj Jessica , Watkins Andrew B. , Kuleshov Yuriy
Published: November 2024

Marine heatwaves (MHWs) have intensified in frequency, duration, and severity over recent decades. These events, defined by unusually warm sea surface temperatures (SSTs), can cause significant ecological impacts. This is particularly so for Pacific Island countries, such as Vanuatu, where communities rely on marine resources for their food and livelihoods. A common ecological response to MHWs is the movement of oceanic species to cooler waters. Predicting such shifts through monitoring SST isotherms can help identify thermal boundaries that marine species favor. This study explores the connection between MHWs, SST isotherm movement, and tuna abundance in Vanuatu. The displacement of the 28 °C isotherm was analyzed across three major MHW events (2008–2009, 2016, and 2021–2022). It was found that MHWs with longer duration and greater intensity caused more significant isotherm displacement. Additionally, the El Niño–Southern Oscillation had an important influence on MHW formation and isotherm movement. The effects of these displacements on tuna distribution varied between events. The ability to monitor MHWs and SST isotherm movement could be an effective instrument for the prediction of areas of suppressed or abundant tuna activity and can be used to aid in the proactive management of food security and fishery sectors.
An Assessment of the Carbon Budget of the Passively Restored Willow Forests Along the Miho River, Central South Korea
Authors: Lim Bong-Soon , Joo Seung-Jin , Seok Ji-Eun , Lee Chang-Seok
Published: November 2024

Climate change is rapidly progressing as the carbon budget balance is broken due to excessive energy and land use. This study was conducted to find and quantify new carbon sinks to implement the carbon neutrality policy prepared by the international community to solve these problems. To reach this goal, an allometric equation of the willow community, which dominates riparian vegetation, was developed and applied to calculate the net primary productivity of the willow community. Furthermore, after the amount of carbon emitted via soil respiration was quantified, the net ecosystem production was calculated by subtracting the amount of soil respiration from the net primary productivity. In comparisons of the results obtained via this process with those obtained from forest vegetation, the willow community, representative of riparian vegetation, showed a much higher carbon sequestration rate than forest vegetation. Considering these results comprehensively, the willow community could be a new and significant carbon absorption source. In this context, proper river restoration should be realized to contribute to carbon neutrality and secure various ecosystem service functions.
Multidisciplinary Treatment of Hemifacial Microsomia: Several Clinical Cases
Authors: Cano-Rosás Mónica , Benito-Cano Juan , Benito-Cano Javier , Diosdado-Cano José María , Benito-Duque Pablo , Curto Adrián
Published: November 2024

Hemifacial microsomia is the second most common congenital anomaly of the craniofacial region. Hemifacial microsomia is characterised by unilateral hypoplasia of the ear. Treatment of this condition depends on the severity of the lesion. The treatment of hemifacial microsomia must be carried out by a multidisciplinary group of professionals familiar with this pathology, including plastic surgeons, parapsychologists, orthodontists, and paediatricians. In hemifacial microsomia, microtia is usually accompanied by alterations of the middle ear. Since the ear develops embryonically from the first and second branchial arches, the facial areas that also develop from these embryonic origins are usually affected to a greater or lesser degree, including through hypoplasia of the jaw, maxilla, zygomatic bones, and temporal bone, among others. Although jaw hypoplasia is the most evident deformity in craniofacial microsomia, microtia is the alteration that often has the greatest aesthetic impact on patients. Alterations in dentition are also common, typically presenting as a cephalad inclination of the anterior occlusal plane of the maxilla and mandible on the affected side. This study aims to review the surgical approach and evaluate the results of a paediatric case of hemifacial microsomia. Hemifacial microsomia is present at birth, and successful reconstruction is essential for the correct integration of such infantile patients into society. Multiple facial asymmetries as well as neonatal onset are a challenge for reconstructive surgery, and the importance of multidisciplinary treatment in these patients must be emphasised.
High-Performance SAW-Based Microfluidic Actuators Composed of Sputtered Al–Cu IDT Electrodes
Authors: Kim Hwansun , Lee Youngjin , Puneetha Peddathimula , An Sung Jin , Park Jae-Cheol , Mallem Siva Pratap Reddy
Published: November 2024

To realize highly sensitive SAW devices, novel Al–Cu thin films were developed using a combinatorial sputtering system. The Al–Cu sample library exhibited a wide range of chemical compositions and electrical resistivities, providing valuable insights for selecting optimal materials for SAW devices. Considering the significant influence of electrode resistivity and density on acoustic wave propagation, an Al–Cu film with 65 at% Al was selected as the IDT electrode material. The selected Al–Cu film demonstrated a resistivity of 6.0 × 10−5 Ω-cm and a density of 4.4 g/cm3, making it suitable for SAW-based microfluidic actuator applications. XRD analysis revealed that the Al–Cu film consisted of a physical mixture of Al and Cu without the formation of Al–Cu alloy phases. The film exhibited a fine-grained microstructure with an average crystallite size of 7.5 nm and surface roughness of approximately 6 nm. The SAW device fabricated with Al–Cu IDT electrodes exhibited excellent acoustic performance, resonating at 143 MHz without frequency shift and achieving an insertion loss of −13.68 dB and a FWHM of 0.41 dB. In contrast, the Au electrode-based SAW device showed significantly degraded acoustic characteristics. Moreover, the SAW-based microfluidic module equipped with optimized Al–Cu IDT electrodes successfully separated 5 μm polystyrene (PS) particles even at high flow rates, outperforming devices with Au IDT electrodes. This enhanced performance can be attributed to the improved resonance characteristics of the SAW device, which resulted in a stronger acoustic radiation force exerted on the PS particles.
Three-Dimensional Micromechanical Simulation and Evaluation of High-Toughness Ultra-Thin Friction Course with X-Ray Computed Tomography
Authors: Wan Cheng , Yi Qiang , Yang Jiankun , Yu Yong , Fang Shuai
Published: November 2024

As a novel pavement wear layer material, the micromechanical mechanisms of High-toughness Ultra-thin Friction Course (HUFC) have not been fully elucidated. This paper presents a new method for the three-dimensional micromechanical simulation of high-toughness asphalt mixtures based on a viscoelastic parameter calibration model. X-ray Computerized Tomography (CT) was employed to scan samples of high-toughness asphalt mixtures to obtain detailed information on the internal structure (aggregate, fine aggregate matrix FAM and voids), and a three-dimensional micromechanical model was constructed based on the real-scale distribution of these components. Aggregates in the high-toughness asphalt mixture were modeled as elastic bodies, while FAM was treated as a viscoelastic material characterized by the Burgers model. Using the Boltzmann linear superposition principle and Laplace transform theory, the viscoelastic properties of FAM were converted into Prony parameters recognizable by finite element software, and the viscoelastic parameters were calibrated. Micromechanical simulations were conducted for three different gradings of high-toughness asphalt mixtures, and the results show that the predicted deformation closely matched the measured deformation. This method accurately reflects the deformation characteristics of different gradings of high-toughness asphalt mixtures, overcoming the limitations of traditional numerical simulations based on homogeneous material models. It represents an advancement and refinement of micromechanical simulation methods for high-toughness asphalt mixtures.
Modified Multiresolution Convolutional Neural Network for Quasi-Periodic Noise Reduction in Phase Shifting Profilometry for 3D Reconstruction
Authors: Espinosa-Bernal Osmar Antonio , Pedraza-Ortega Jesús Carlos , Aceves-Fernandez Marco Antonio , Ramos-Arreguín Juan Manuel , Tovar-Arriaga Saul , Gorrostieta-Hurtado Efrén
Published: November 2024

Fringe profilometry is a method that obtains the 3D information of objects by projecting a pattern of fringes. The three-step technique uses only three images to acquire the 3D information from an object, and many studies have been conducted to improve this technique. However, there is a problem that is inherent to this technique, and that is the quasi-periodic noise that appears due to this technique and considerably affects the final 3D object reconstructed. Many studies have been carried out to tackle this problem to obtain a 3D object close to the original one. The application of deep learning in many areas of research presents a great opportunity to to reduce or eliminate the quasi-periodic noise that affects images. Therefore, a model of convolutional neural network along with four different patterns of frequencies projected in the three-step technique is researched in this work. The inferences produced by models trained with different frequencies are compared with the original ones both qualitatively and quantitatively.
Manipulation of Phototactic Responses by Two-Spotted Spider Mites to Improve Performance of Miticides
Authors: Nansen Christian , Savi Patrice Jacob , Ward Tora , Khodaverdi Haleh , Lieth Johann Heinrich , Mantri Anil V.
Published: November 2024

Insight into phototactic responses by herbivorous crop pests may be used to manipulate their vertical distribution in crop canopies. Here, we tested the hypothesis that the deployment of specific light sources elicits positive or negative phototactic responses and can be used to enhance performance of miticide applications. We characterized movement responses by two-spotted spider mites (Tetranychus urticae) (spider mites) to seven light sources [ambient (control), UV-C, UV-B, blue, red, white, and near-infrared (NIR)] under experimental conditions. Separate experiments were conducted with/without the presence of a shelter. An analytical approach based on linear regression coefficients (intercept and slope) from observations in ascending order was used. Linear regression coefficients from UV-B indicated significantly negative phototactic bio-response. We examined settlement of spider mites when exposed to 11 light source configurations and with adaxial leaf sides facing either upwards or downwards. This experiment revealed strong positive and negative phototactic bio-responses to blue light and UV-B light, respectively. As a validation experiment, soybean plants were experimentally infested with spider mites and subjected to one of the following three treatments: (1) no treatment (control), (2) miticide [pyrethrins and Beauveria bassiana (BotaniGard Maxx)] only, and (3) a combination of blue and UV-B for 10 min immediately prior to miticide application. Integration of miticide application with prior deployment of blue and UV-B lights significantly increased the performance of miticide application. Results from this study supported the hypothesis. As a pest management approach, the integration of blue light (to elicit positive phototactic response) and UV-B (to elicit negative phototactic response) is believed to be of particular relevance to organic crop producers and/or to producers of crops for which limited numbers of miticides are registered.
Update on Practical Management of Early-Stage Non-Small Cell Lung Cancer (NSCLC): A Report from the Ontario Forum
Authors: Cheema Parneet K. , Wheatley-Price Paul F. , Cecchini Matthew J. , Ellis Peter M. , Louie Alexander V. , Moore Sara , Sheffield Brandon S. , Spicer Jonathan D. , Villeneuve Patrick James , Leighl Natasha B.
Published: November 2024

Therapeutic strategies for early-stage non-small cell lung cancer (NSCLC) are advancing, with immune checkpoint inhibitors (ICIs) and targeted therapies making their way into neoadjuvant and adjuvant settings. With recent advances, there was a need for multidisciplinary lung cancer healthcare providers from across Ontario to convene and review recent data from practical and implementation standpoints. The focus was on the following questions: (1) To what extent do patient (e.g., history of smoking) and disease (e.g., histology, tumor burden, nodal involvement) characteristics influence treatment approaches? (2) What are the surgical considerations in early-stage NSCLC? (3) What is the role of radiation therapy in the context of recent evidence? (4) What is the impact of biomarker testing on treatment planning? Ongoing challenges, treatment gaps, outstanding questions, and controversies with the data were assessed through a pre-meeting survey, interactive cases, and polling questions. By reviewing practice patterns across Ontario cancer centers in the context of evolving clinical data, Health Canada indications, and provincial (Cancer Care Ontario [CCO]) funding approvals, physicians treating lung cancer voiced their opinions on how new approaches should be integrated into provincial treatment algorithms. This report summarizes the forum outcomes, including pre-meeting survey and polling question results, as well as agreements on treatment approaches based on specific patient scenarios.
Influence of Temperature Variability on the Efficacy of Negative Ions in Removing Particulate Matter and Pollutants: An Experimental Database
Authors: Ortiz-Grisales Paola M. , Gutiérrez-León Leidy , Zuluaga-Ríos Carlos D.
Published: November 2024

Cities globally must make urgent decisions to ensure a sustainable future as rising pollution, particularly PM2.5, poses severe health risks like respiratory and heart diseases. PM2.5’s harmful composition also impacts vegetation and the environment. Immediate government intervention is necessary to mitigate these effects. This study tackles the urgent problem of reducing PM2.5 levels in Medellín’s urban and indoor environments, where pollution presents serious health risks. To explore effective solutions, this research provides new data on the interaction between particulate matter from various pollutants and negative ions under different temperature conditions, offering valuable insights into air quality improvement strategies. Using a high-voltage system, ions bind to pollutants, accelerating their removal. Experiments measured temperature, humidity, formaldehyde, volatile organic compounds, negative ions, and PM2.5 in a 40 cm3 chamber across various conditions. Pollutants tested included cigarette smoke, incense, charcoal, and gasoline at two voltage levels and three temperature ranges. The data, available in CSV format, were based on 36,000 samples and repeated tests for reliability. This resource is designed to support studies investigating particulate matter control in urban and indoor environments, as well as to improve our understanding of negative ion-based air purification processes. The data are publicly available and structured in formats compatible with leading data analysis platforms.
Searching for New Antibacterial Compounds Against Staphylococcus aureus: A Computational Study on the Binding Between FtsZ and FtsA
Authors: Demesa-Castañeda Alba V. , Pérez David J. , Millán-Pacheco César , Hernández-Mendoza Armando , Razo-Hernández Rodrigo Said
Published: November 2024

Background: Staphylococcus aureus is a pathogen that has become resistant to different antibiotics, which makes it a threat to human health. Although the first penicillin-resistant strain appeared in 1945, nowadays, there are just a few alternatives to fight it. To circumvent this issue, novel approaches to develop drugs to target proteins of the bacteria cytoskeleton, essential for bacteria’s binary fission, are being developed. FtsZ and FtsA are two proteins that are key for the initial stages of binary fission. On one side, FtsZ forms a polymeric circular structure called the Z ring; meanwhile, FtsA binds to the cell membrane and then anchors to the Z ring. According to the literature, this interaction occurs within the C-terminus domain of FtsZ, which is mainly disordered. Objective: In this work, we studied the binding of FtsZ to FtsA using computational chemistry tools to identify the interactions between the two proteins to further use this information for the search of potential protein-protein binding inhibitors (PPBIs). Methods: We made a bioinformatic analysis to obtain a representative sequence of FtsZ and FtsA of Staphylococcus aureus. With this information, we built homology models of the FtsZ to carry out the molecular docking with the FtsA. Furthermore, alanine scanning was conducted to identify the key residues forming the FtsZ–FtsA complex. Finally, we used this information to generate a pharmacophore model to carry out a virtual screening approach. Results: We identified the key residues forming the FtsZ-FtsA complex as well as five molecules with high potential as PPBIs.
Cardiac Computed Tomography as a Method of Diagnosing the Type of Cardiac Tumor—Example of Interatrial Septal Lipoma Filling the Right Atrium
Authors: Gać Paweł , Jaworski Arkadiusz , Parfianowicz Agnieszka , Surma Alicja , Jakubowska-Martyniuk Anna , Żórawik Aleksandra , Poręba Rafał
Published: November 2024

Cardiac tumors present substantial diagnostic challenges due to their diverse manifestations and similarity to other cardiac pathologies. Cardiac lipomas are rare tumors that originate from adipose cells and can develop in any location within the heart. Cardiac lipomas account for 2.4% of all primary cardiac tumors. Most lipomas are located within the cardiac chambers. Among the lipomas occurring within the cardiac chambers, the most common localization is the right atrium. Currently, the gold standard for imaging cardiac tumors is cardiac magnetic resonance (CMR). Despite the significant advantages of CMR, cardiac computed tomography angiography (CCTA) continues to be a valuable technique when CMR is either unavailable or contraindicated. In some cardiac tumors, CCTA can identify the type of tumor. A classic example of this type is a lipoma. We present images of a large interatrial septal lipoma filling the right atrium diagnosed by CCTA in a 57-year-old female Caucasian patient. In summary, CCTA effectively identifies lipomas’ characteristic features and provides crucial information for appropriate management.
Spontaneous Transvaginal Small Bowel Evisceration After Laparoscopic Hysterectomy
Authors: Kountouri Ismini , Giotas Amyntas , Gkogkos Christos , Katsarelas Ioannis , Nachopoulos Panagiotis , Faseki Afroditi , Chatzinas Dimitrios , Panagiotou Alexandra , Polychronidis Athanasios , Husamieh Mohammad , Dimasis Periklis , Gkiatas Nikolaos , Manolakaki Dimitra , Chandolias Miltiadis
Published: November 2024

Vaginal cuff dehiscence can be a rare complication of total hysterectomy, with an estimated prevalence of 0.032% to 1.25% and a high mortality rate of 6 to 10%. Dehiscence is also reported in cases following total laparoscopic hysterectomy, with a prevalence of 0.87%. This case report details the emergency management of a 59-year-old female who complained of abdominal and pelvic pain and the feeling of a foreign body in her vagina. The patient reported a history of laparoscopic total hysterectomy 6 months prior to presenting at the Emergency Department. A clinical examination revealed small bowel loops protruding through the vagina. The patient underwent exploratory laparotomy through a Pfannenstiel incision, and the terminal ileum was found prolapsing through the vaginal cuff. The bowel loops were identified as viable and the vagina was sutured. The patient had an unremarked post operative course. This case report showcases that in patients with transvaginal evisceration, immediate surgical management is crucial in order to avoid serious life threatening complications, and both surgeons and gynecologists should remain vigilant regarding this pathology.
A Comprehensive Review of Clinical Studies Applying Flow-Mediated Dilation
Authors: Ahn Yuran , Aung Nay , Ahn Hyo-Suk
Published: November 2024

Flow-mediated dilation (FMD) is a noninvasive method to evaluate vascular endothelial function, which manifests the vascular inflammatory response, cell proliferation, and autoregulation. Since FMD is noninvasive and assesses commonly in the brachial artery by ultrasound, compared to other invasive methods such as optical coherence tomography (OCT) and intravascular ultrasound (IVUS), it is widely used to evaluate endothelial function and allows serial assessment. In this review, we present the currently accepted mechanisms and methods of FMD measurement with the studies applied in the current clinical practice using FMD. After all, the association with cardiovascular diseases is of substance, and so we introduce clinical studies of FMD related to cardiovascular disease such as diabetes, hyperlipidemia, chronic kidney disease, coronary artery disease, and peripheral vascular disease. In addition, studies related to pregnancy and COVID-19 were also inspected. Yet, endothelial examination is not endorsed as a cardiovascular prevention measure, for the lack of a clear standardized value methodology. Still, many studies recommend practicable FMD and would be a better prognostic value in the cardiovascular prognosis in future clinical research.
Modified FIB-4 Index in Type 2 Diabetes Mellitus with Steatosis: A Non-Linear Predictive Model for Advanced Hepatic Fibrosis
Authors: Kim Jonghyun , Ito Takanori , Arai Taeang , Atsukawa Masanori , Kawanaka Miwa , Toyoda Hidenori , Honda Takashi , Yu Ming-Lung , Yoon Eileen L. , Jun Dae Won , Cha Kyungjoon , Nguyen Mindie H.
Published: November 2024

Background: The Fibrosis-4 (FIB-4) index is widely recommended as a first-tier method for screening advanced hepatic fibrosis; however, its diagnostic performance is known to be suboptimal in patients with Type 2 diabetes mellitus (T2DM). We aim to propose a modified FIB-4, using the parameters of the existing FIB-4, tailored specifically for diabetic patients with metabolic dysfunction-associated steatotic liver disease (MASLD). Methods: A total of 1503 patients who underwent liver biopsy were divided into T2DM (n = 517) and non-T2DM (n = 986) groups. The model was developed using multiple regression analysis in the derivation cohort and validated in the validation cohort. Diagnostic accuracy was evaluated using the area under the receiver operating characteristic (AUC) curves. Results: Among the 1503 individuals, those with T2DM were older, more likely to be male, and had a higher prevalence of advanced hepatic fibrosis (≥F3) compared to non-T2DM individuals. Independent risk factors for advanced fibrosis in T2DM included age, AST, AST/ALT ratio, albumin, triglycerides, and platelet count. The optimized FIB-4 model for T2DM with MASLD (Diabetes Fibrosis Index) demonstrated superior diagnostic accuracy (AUC 0.771) compared to the FIB-4 (AUC 0.735, p = 0.012). The model showed a higher negative predictive value than the original FIB-4 across all age groups in the diabetic group. Conclusions: The newly optimized FIB-4 model for T2DM with MASLD (Diabetes Fibrosis Index), incorporating a non-linear predictive model, improves diagnostic performance (AUC) and the negative predictive value in MASLD with T2DM.
Combined Use of External Iliac Lymph Node Count and Bone Scintigraphy for PJI Diagnosis: A Prospective Study
Authors: Zhou Haotian , Yang Yaji , Li Jia , Hu Qianshui , Li Feilong , Qin Leilei , Huang Wei , Wang Hai , Cheng Qiang
Published: November 2024

Background: The reactive enlargement of external iliac lymph nodes and increased blood flow in the infected region are commonly observed in lower limb infections. We aimed to differentiate between aseptic loosening and periprosthetic joint infection (PJI) after joint replacement surgery by quantifying the number of enlarged external iliac lymph nodes and using bone scintigraphy to monitor blood flow. Methods: We recruited 124 patients undergoing revision surgery for aseptic loosening or PJI. All the patients underwent preoperative dual-energy computed tomography (DECT) imaging for external iliac lymph nodes and bone scintigraphy. The diagnostic value was evaluated using ROC curve analysis. Results: The number of enlarged external iliac lymph nodes was significantly higher in the PJI group than in the aseptic failure group (4.0 versus. 1.0, p value < 0.001). The median affected/unaffected side ratio in the blood pool phase of ECT in the PJI group was 1.49, significantly higher than the aseptic failure group’s median ratio of 1.04 (p value < 0.001). The AUC for diagnosing PJI using the number of enlarged lymph nodes alone was 0.91, and when using the bone scintigraphy blood pool phase alone, the AUC was 0.89. When both metrics were combined, the AUC increased to 0.95, which was higher than the AUCs for the ESR (AUC = 0.83), CRP (AUC = 0.76), and synovial fluid PMN% (AUC = 0.62). Conclusions: Combining the enlargement of the lymph node count with the bone scintigraphy blood pool phase is a promising approach for diagnosing PJI.