bluuebunny/crossref_metadata_2025 huggingface dataset:
Cathepsin B Deficiency Improves Memory Deficits and Reduces Amyloid-β in hAβPP Mouse Models Representing the Major Sporadic Alzheimer’s Disease Condition
Authors: Hook Gregory , Kindy Mark , Hook Vivian
Published: March 2023

The lysosomal cysteine protease cathepsin B (CTSB) has been suggested as a biomarker for Alzheimer’s disease (AD) because elevated serum CTSB in AD patients has been found to correlate with cognitive dysfunction. Furthermore, CTSB gene knockout (KO) in non-transgenic and transgenic AD animal models showed that elimination of CTSB improved memory deficits. However, conflicting CTSB KO results on amyloid-β (Aβ) pathology in transgenic AD models have been reported. The conflict is resolved here as likely being due to the different hAβPP transgenes used in the different AD mouse models. CTSB gene KO reduced wild-type (Wt) β-secretase activity, brain Aβ, pyroglutamate-Aβ, amyloid plaque, and memory deficits in models that used cDNA transgenes expressing hAβPP isoform 695. But in models that used mutated mini transgenes expressing hAβPP isoforms 751 and 770, CTSB KO had no effect on Wt β-secretase activity and slightly increased brain Aβ. All models expressed the AβPP transgenes in neurons. These conflicting results in Wt β-secretase activity models can be explained by hAβPP isoform specific cellular expression, proteolysis, and subcellular processing. CTSB KO had no effect on Swedish mutant (Swe) β-secretase activity in hAβPP695 and hAβPP751/770 models. Different proteolytic sensitivities for hAβPP with Wt versus Swe β-secretase site sequences may explain the different CTSB β-secretase effects in hAβPP695 models. But since the vast majority of sporadic AD patients have Wt β-secretase activity, the CTSB effects on Swe β-secretase activity are of little importance to the general AD population. As neurons naturally produce and process hAβPP isoform 695 and not the 751 and 770 isoforms, only the hAβPP695 Wt models mimic the natural neuronal hAβPP processing and Aβ production occurring in most AD patients. Significantly, these CTSB KO findings in the hAβPP695 Wt models demonstrate that CTSB participates in memory deficits and production of pyroglutamate-Aβ (pyroglu-Aβ), which provide rationale for future investigation of CTSB inhibitors in AD therapeutics development.
Development and Characterization of Mouse-Specific Anti-Tau Monoclonal Antibodies: Relevance for Analysis of Murine Tau in Cerebrospinal Fluid
Authors: Rodrigues Martins Dina , Vandermeeren Marc , Van Kolen Kristof , Brepoels Eddy , Borgers Marianne , Wintmolders Cindy , Delay Charlotte , Bottelbergs Astrid , Mercken Marc , Theunis Clara
Published: March 2023

Background: Clearance of tau seeds by immunization with tau antibodies is currently evaluated as therapeutic strategy to block the spreading of tau pathology in Alzheimer’s disease and other tauopathies. Preclinical evaluation of passive immunotherapy is performed in different cellular culture systems and in wild-type and human tau transgenic mouse models. Depending on the preclinical model used, tau seeds or induced aggregates can either be of mouse, human or mixed origin. Objective: We aimed to develop human and mouse tau-specific antibodies to discriminate between the endogenous tau and the introduced form in preclinical models. Methods: Using hybridoma technology, we developed human and mouse tau-specific antibodies that were then used to develop several assays to specifically detect mouse tau. Results: Four antibodies, mTau3, mTau5, mTau8, and mTau9, with a high degree of specificity for mouse tau were identified. Additionally, their potential application in highly sensitive immunoassays to measure tau in mouse brain homogenate and cerebrospinal fluid is illustrated, as well as their application for specific endogenous mouse tau aggregation detection. Conclusion: The antibodies reported here can be very important tools to better interpret the results obtained from different model systems as well as to study the role of endogenous tau in tau aggregation and pathology observed in the diverse mouse models available.
Emotional Investment, Commitment and Quality of Life in Pre-Marital Relationships among Young Adults in Pakistan
Authors: Kashaf Maqbool  , Bilal Ahmed , Arham Fatima  , Mehroze Farooq Khan
Published: March 2023

The purpose of the current research was to explore the relationship between emotional investment, commitment, and quality of life in pre-marital relationships in youth. The cross-sectional survey design was used. In total, 150 men and women participated in the research. Investment Model Scale, Relationship Assessment Scale, Quality-of-Life Scale, and Pre-marital Sexual Permissive Scale were used to assess the study variables. Findings revealed that men demand women to engage more in sexual relationships as a marital requisite which is why most male partners convince their female partner to have sex as a commitment to marriage. Furthermore, emotionally satisfying relationships promote positivity and vice versa impacting academic achievement whilst promoting anxiety, depression, and low self-esteem among both men and women. Also, women have more negative mental health in their pre-marital relationships as compared to men. Researchers also found that care, happiness, and empathy in the relationship have positive effects on mental health of young adults. This research will enable young adults and marital counselors alike in dealing with the complexities of premarital relationships.
Job Satisfaction and Work and social Adjustment between Retired Army Employees and Civil Employees Working at Civilian Setting
Authors: Sumbal Rosheen  , Saira Maqsood
Published: March 2023

The study explores the relationship of job satisfaction and work and social adjustment between retired army and civil employees working in civilian setting. 150 employees were selected in the study in which 75 were retired army persons and 75 were civilian which was working at civil settings. Cross sectional research design and convenient sampling was used to collect data. Generic Job Satisfaction Scale and Work and Social Adjustment Scale were used to collect data. Independent Samples t-Test, Pearson Correlation analysis and Linear Regression analysis was applied to find out results. The findings showed that the difference was significant, as retired army employees were more satisfied than civilians. Work adjustment and job satisfaction had a significant relationship and work adjustment was significantly predicting job satisfaction. This study will help authorities figure out for organization to how to improve working environment and increase productivity and standardized work settings.
Perceived Stigma, Help Seeking Behavior and Psychological Well-being, among Substance Abuse Patient
Authors: Hassan Noor , Asad Shamaila , Jamil Farheen
Published: March 2023

This research was intended to examine the interrelationship of perceived stigma, help-seeking behavior, and psychological well-being among Substance abuse patients. A correlational research design was employed and 80 substance abuse patients between the age range 18-45 (Mean=31.46, SD=4.77) were recruited in the study. The Perceived Stigma of Addiction Scale, Psychological Wellbeing Scale, and general Help-seeking Questionnaire was used as assessment measures. The results showed that perceived stigma of substance abuse was negatively correlated with psychological well-being while no significant correlation was found between help-seeking behavior and psychological well-being. Perceived stigma came out to be a significant negative predictor of psychological well-being among substance abuse patients. Help-seeking behavior did not mediate the relationship between perceived stigma and psychological well-being. The results of this study will be used in designing and modifying future assessment measures, treatment practices, and fitness strategies.
Alapjog-korlátozás a helyi képviseleti szerv által?!
Authors: Magyar Áron
Published: March 2023

A magyar alkotmányos gyakorlatban és a szakirodalomban meglehetősen jól kikristályosodott fogalma és definíciója van a tulajdon alkotmányos védelmének. Amikor a tulajdonhoz való jog korlátozását vizsgáljuk, az első fogalom, amellyel találkozunk, a kisajátítás, illetve ezzel kapcsolatban az Alaptörvény XIII. cikk (2) bekezdése, esetenként a Grundgesetz Artikel 14, vagy talán az Emberi és polgári jogok nyilatkozatának 17. cikkelye juthat eszünkbe. Eme fogalmi keretek összefüggenek, mivel végső soron a hatályos jogrendszerben is a kisajátításra modellezve alkalmazzuk a tulajdonkorlátozó intézkedéseket. Jelen írás fő célja, hogy problémafelvető jelleggel megjelöljön egy kevésbé ismert és talán kevésbé alkalmazott jogintézményt, amely nagyon sok hasonlóságot mutat a kisajátítással, azonban a helyi képviseleti szerv (a helyi önkormányzat képviselő-testületének) alkotmányos beágyazottságának vizsgálatához is elvezethet.
Pandemi Sürecinde Gastronomi Turistlerinin Yöresel Yemek Tüketim Alışkanlıkları, Tutumları ve Tatil Tercihlerindeki Değişimlerinin Belirlenmesi
Authors: ÇELEBİ Emre , İLBAN Mehmet Oğuzhan
Published: March 2023

Bu çalışmanın temel amacı gastronomi turistlerinin pandemi döneminde değişiklik gösteren tatil tercihlerinin, gastronomi turizminin pandemi sürecinde hissedeceği etkilerin ve gastronomi turistlerinin yöresel yemek tüketim alışkanlıkları ile tutumlarının belirlenmesidir. Edremit Körfezi' nde ikamet eden gastronomi turistlerinin evreni oluşturduğu bu çalışmada; 316 anket formu değerlendirmeye alınmıştır. Veriler SPSS programında incelenmiştir. Verilerin analizi için bağımsız örneklem T-Testi, One Way ANOVA, Pearson korelasyon analizi ve basit doğrusal regresyon analizi kullanılmıştır. Gerçekleştirilen analizlere göre; katılımcıların tatil tercihlerinde anlamlı düzeyde değişiklikler olduğu; buna göre doğa odaklı turizm türlerine ilginin arttığı, tatil yerlerinde hijyen unsurunun daha önemli olacağı ve bireysel tatil programlarının ön planda tutulacağı gibi sonuçlara ulaşılmıştır. Ek olarak katılımcıların gastronomi turizmine katılım isteklerinde azalma olmasına karşın yöresel yemek tüketim alışkanlıkları ve tutumlarının yüksek olması ve gastronomi turizmine katılım isteğindeki değişimin yöresel yemek tutumları üzerinde anlamlı etkiye sahip olduğu sonuçlarına varılmıştır.
Kadın Gezginlerin Deneyimleri Üzerine Bir Sosyal Medya Araştırması
Authors: ÇİÇEK Dönüş , AŞAN Kübra
Published: March 2023

Bu çalışmanın amacı kadın gezginlerin Instagram hesaplarında yaptıkları paylaşımlar kapsamında deneyimlerinin incelenmesidir. Çalışma sonuçları kadın gezgin deneyimlerinin anlaşılmasında yeni bakış açıları sunmaktadır. Çalışmanın veri seti, Phantombuster uygulaması kullanılarak kaydedilen, 11 Ağustos 2021 ve 15 Ekim 2021 tarihleri arasında #gezginkadinlar etiketiyle yapılan toplam 3072 Instagram gönderisinden oluşmaktadır. Çalışmada ilk olarak veri seti düzenlemesi yapılmış, ticari girişim ve işletmelerin reklam veya tanıtımlarıyla ilgili olduğu belirlenen gönderiler veri setinden çıkarılmıştır. İkinci olarak, deneyimin bireysel bir kazanım olduğu varsayımıyla çalışmanın kapsamı, “ben” dilinin kullanıldığı ifadeler ile sınırlandırılmıştır. Böylece 276 farklı hesaptan gönderilen toplam 461 gönderi betimsel ve tematik içerik analizine tabi tutulmuştur. Analiz sonucunda hakikat deneyimi, eğlence deneyimi, varoluş deneyimi ve sosyo-kültürel topluluk deneyimi olmak üzere dört farklı tema altında kadın deneyimleri açıklanmıştır. Bulgulardan hareketle kadın gezgin deneyimlerine ilişkin teorik ve pratik çıkarımlar sunulmuştur.
An 8-year-old boy with diffuse cystic pulmonary tuberculosis: An intriguing story
Authors: Tsanglao Wonashi R , Kikon Sulanthung , Aier Tenukala
Published: March 2023

Diffuse cystic lung disease due to pulmonary tuberculosis (TB) is rare. We describe an 8-year-old boy who presented with acute onset respiratory distress while on a compliant anti-tubercular treatment for a recently diagnosed pulmonary TB. On clinical examination, hypoxemia, clubbing, and features of the right-sided heart failure were observed. High-resolution computed tomography of the chest revealed extensive cystic lung parenchymal changes with ground glassing and consolidation, and echocardiography indicated the presence of pulmonary arterial hypertension. His treatment included supplemental oxygen, sildenafil, prednisolone, and anti-tubercular drugs. At the two-year follow-up, the patient showed complete clinical recovery and resolution of cysts on the chest X-ray.
Human Anatomi Recognition Using Augmented Reality With Marker Based Method Tracking
Authors: Setiawan Agustinus Eko , Aras Irsan , Andika Tahta Herdian , Hendrawan Putri Adelia Insi
Published: March 2023

Pembelajaran secara online adalah terobosan baru dalam dunia pendidikan. Adaptasi kehidupan baru setelah pasca covid-19, dunia pendidikan harus mampu membuat terobosan baru dalam sistem pembelajaran. Khususnya dalam mata kuliah atau pelajaran praktikum, jika tidak mampu menyiapkan sistem pembelajaran yang efisien maka akan memperburuk kondisi pengetahuan dan pemahaman mahasiswa atau pelajar.Upaya yang perlu dilakukan adalah pemanfaatan teknologi augmented reality, salah satunya adalah pengenalan anatomi tubuh manusia untuk pembelajaran bagi mahasiswa atau pelajar. Anatomi tubuh manusia bisa ditampilkan ke dalam bentuk nyata tiga dimensi (3D), sehingga mahasiswa atau pelajar sekolah dapat memvisualisasikan anatomi tubuh manusia dalam bentuk gambar 3D yang mirip dengan organ tubuh manusia aslinya. Dalam penelitian ini akan dibuat aplikasi ANAR (Anatomy in Augmented Reality), aplikasi pembelajaran anatomi ini menggunakan teknologi mobile augmented reality dengan menggunakan metode Marker Based Tracking. Berdasarkan System Usability Score (SUS), range nilai kebergunaan Aplikasi ANAR (Anatomy in Augmented Reality) ada pada range excellent yaitu sebesar 85,5%. Maka dari itu, aplikasi ANAR (Anatomy in Augmented Reality) berhasil membangun sistem yang user-friendly dengan tingkat usability yang tinggi dengan menunjukkan akurasi mudah dipelajari (learnability), 87,6% akurasi efisiensi (efficiency), 90% akurasi mudah diingat (memorability), 70% akurasi kesalahan (errors), dan 85,50% akurasi dari kepuasan (satisfaction). Aplikasi ini sangat bermanfaat dalam memberikan visualisasi materi pembelajaran dan menciptakan minat yang lebih baik dalam mempelajari mata pelajaran materi anatomi.
Методичні аспекти розрахунку показників рентабельності суб’єкта малого підприємництва
Authors: Гавриш Ольга , Порсюрова Ірина
Published: March 2023

За сучасних умов розвитку бізнес-середовища суб’єкти малого підприємництва відіграють важливу роль в економіці. Діяльність суб’єктів малого підприємництва спрямована на отримання прибутку у короткостроковій перспективі, і їх прибутковість указує на якість управлінських рішень. Рентабельність є якісним показником ефективності діяльності суб’єкта малого підприємництва, на основі отриманих результатів розрахунків приймають управлінські рішення, пов’язані з фінансовими ресурсами, тобто мають вплив на розподіл прибутку. Зважаючи на вищезазначене, актуалізується дослідження методики розрахунку показників рентабельності суб’єктів малого підприємництва у теоретичній та практичній площинах. У статті розглянуто особливості малого підприємства як одного із суб’єктів ринкової економіки, проаналізовано динамічні коливання їх кількості за 2010–2020 рр. та визначено причини змін організаційно-економічного характеру. Для фінансового аналізу систематизовано показники рентабельності, а саме розрахунок співвідношення чистого прибутку до рівня продажів, активів, власного капіталу і витрат, що характеризують ефективність діяльності малого підприємства та його фінансовий стан. На базі фінансової звітності діючого суб’єкта господарювання здійснено розрахунок показників рентабельності та охарактеризовано рівень його прибутковості та фінансовий стан. Практичну цінність становлять запропоновані заходи для фінансової стабілізації малого підприємства та напрями, що спрямовані на зменшення фінансових зобов’язань і збільшення грошових активів, що забезпечують ці зобов’язання. Визначено резерви зростання прибутку суб’єкта малого підприємництва, що спрямовані на зміцнення його фінансового стану та соціальної сфери. Окреслено, що порядок використання прибутку малого підприємства визначає власник, та переважно прибуток розподіляється на економічний розвиток та соціальні потреби підприємства. Отримані результати дослідження повинні забезпечити поліпшення організації методики аналізу фінансових результатів суб’єктів малого підприємництва та підвищити ефективність фінансового управління підприємством.
Developing systems theory in soil agroecology: Incorporating heterogeneity and dynamic instability
Authors: Medina Nicholas , Vandermeer John
Published: March 2023

Ecosystem management is integral to the future of soils, yet anthropogenic drivers represent a key source of uncertainty in ecosystem models. First- and new-generation soil models formulate many soil pools using first-order decomposition, which tends to generate simpler yet numerous parameters. Systems or complexity theory, developed across various scientific and social fields, may help improve robustness of soil models, by offering consistent assumptions about system openness, potential dynamic instability and distance from commonly assumed stable equilibria, as well as new analytical tools for formulating more generalized model structures that reduce parameter space and yield a wider array of possible model outcomes, such as quickly shrinking carbon stocks with pulsing or lagged respiration. This paper builds on recent perspectives of soil modeling to ask how various soil functions can be better understood by applying a complex systems lens. We synthesized previous literature reviews with concepts from non-linear dynamical systems in theoretical ecology and soil sciences more broadly to identify areas for further study that may help improve the robustness of soil models under the uncertainty of human activities and management. Three broad dynamical concepts were highlighted: soil variable memory or state-dependence, oscillations, and tipping points or hysteresis. These themes represent less intuitive yet key dynamics that can emerge after assuming nuanced observations, such as reversibility of organo-mineral associations, dynamic aggregate- and pore hierarchies, persistent wet-dry cycles, higher-order microbial community and predator-prey interactions, cumulative legacy land use history, and social management interactions and/or cooperation. We discuss how these aspects may contribute useful analytical tools, metrics, and frameworks that help integrate the uncertainties in future soil states, ranging from micro- to regional scales, including those indirectly affected by human activities and management decisions. Overall, this study highlights the potential benefits of incorporating spatial heterogeneity and dynamic instabilities into future model representations of whole soil processes. Additionally, it advocates for transdisciplinary collaborations between natural and social scientists, extending research into anthropedology and biogeosociochemistry, to better integrate and understand longer-term anthropogenic drivers of soil processes, potentially from soil structural dynamics to microbial community and food web ecology.
WORK EXPERIENCE OF AN ENTOMOLOGIST IN THE SYSTEM OF SANITARY AND EPIDEMIOLOGICAL SERVICE
Authors:   Center of Hygiene and Epidemiology in the Voronezh Region, Voronezh, Gerik E.P.
Published: March 2023

The main issues of medical entomology are considered, in the solution of which the author of the article, who has worked in the sanitary service of the Voronezh region for 50 years, participated. Key words: blood-sucking arthropods, malaria, natural focal infections.
Innovation And Creativity Based Training Untuk Meningkatkan Kompetensi Pedagogik Guru Dalam Pembelajaran Bahasa Inggris
Authors: Hawanti Santhy , Suwartono Suwartono , Purwidianti Wida , Mujirahayu Tri Septin , Anjarani Shelia
Published: March 2023

Abstract: Improving the competence of English teachers is necessary to make English learners more qualified. Technological developments and the demands of the global era have created problems in ELT, one of which is the limited competence of teachers to conduct creative and innovative learning. Training is one solution to improve teachers’ pedagogical competence in implementing learning. Innovative and Creative-Based Training is training to develop teacher pedagogical competence in learning English through technology integration in the classroom. The training is attended by English teachers online. The training presents some materials on social media and technology for teaching English. The training participants reported that their knowledge of how to teach creatively and innovatively through integrating technology in the classroom improved after attending this training. This report is obtained from analyzing the questionnaire results after the training activities.          Keywords: pedagogic competence, innovative, creative, learningAbstrak: Peningkatan kompetensi guru Bahasa Inggris menjadi suatu kebutuhan dalam upaya menjadikan pembelajaran bahasa Inggris yang lebih berkualitas. Perkembangan teknologi dan tuntutan jaman meninggalkan beberapa masalah, salah satunya adalah keterbatasan kompetensi guru untuk melaksanakan pembelajaran yang kreatif dan inovatif. Pelatihan menjadi salah satu solusi meningkatkan kompetensi pedagogik guru dalam melaksanakan pembelajaran. Innovative and Creative Based Training merupakan pelatihan pengembangan kompetensi pedagogik guru dalam pembelajaran bahasa Inggris melalui integrasi teknologi di kelas. Pelatihan diikuti oleh guru bahasa Inggris SMP dan SMA sederajat di Kabupaten Purbalingga. Kegiatan pelatihan di-lakukan secara daring atau online. Pelatihan menyajikan materi tentang penggunaan media   sosial dan teknologi untuk pengajaran Bahasa Inggris. Peserta pelatihan menyampaikan bahwa setelah mengikuti pelatiahn ini pengetahuan mereka terkait bagaimana mengajar yang kreatif dan inovatif melalui integrasi teknologi di kelas. Hal ini diperoleh dari analisis hasil angket yang diberikan setelah kegiatan pelatihan.Kata kunci: kompetensi; kreatif; inovatif; pedagogik; pembelajaran
Pendampingan TPACK (Technological Pedagogic and Content Knowledge) di SMA Negeri 1 Pengasih
Authors: Nuryadi Nuryadi , Marhaeni Nafida Hetty , Rozi Anief Fauzan
Published: March 2023

The TPACK (Technological Pedagogic Content Learning) approach is an approach that contains four types of mandatory competencies for professional teachers. This is because the mastery of the interaction between pedagogy and content to implement strategies that help students understand the material needs to be mastered by professional teachers. Therefore, the purpose of this service is to provide TPACK assistance in the form of developing technology-based learning content at Pengasih 1 Public High School. The method of implementing community service is carried out online through training, workshops and mentoring. The results of the service show that teachers at SMA Negeri 1 Pengasih are able to create learning content that is integrated with technology through the help of a liveworksheet website. In addition, teachers' knowledge of the integration of pedagogic, content, and technology in learning is increasing because of this training. Therefore, this service has been able to achieve the target set by the servant, namely making teachers at SMA Negeri 1 Pengasih able to implement TPACK in learning.
Sosialisasi Pemahaman Guru Tentang Pendidikan Anti Kekerasan Seksual di SD Negeri 104/II Sungai Pinang Kabupaten Bungo
Authors: Putra Randi Eka , Agrita Tri Wera , Wulandari Titis , Habibi Zirul
Published: March 2023

Pelecehan anak merajalela di era digital pada saat ini, bahkan kekerasan seksual sudah menjadi pemikiran yang menakutkan bagi anak-anak di Indonesia. Kekerasan fisik dan atau psikis di Indonesia di latarbelakangi oleh beberapa faktor, salah satunya pengaruh negatif teknologi dan lingkungan sosial-budaya. Kasus perundungan di media sosial sering terjadi, tahun 2021 kekerasan seksual mencapai 8.730. Kasus pemerkosaan kini sering terdengar di publik, seperti juga diberitakan secara luas di media. Kegiatan sosialisasi dilakukan secara tatap muka pukul 13.00 s/d 15.00 wib, pada hari selasa, tanggal 18 Oktober 2022 diikuti oleh 30 peserta. Para peserta yang mengikuti kegiatan ini adalah para guru yang mengajar di SD Negeri 104/II Sungai Pinang dengan harapan guru dapat memahami tentang anti kekerasan seksual dan dapat di implementasikan pada proses pembelajaran. Hasil kegiatan yang telah dilaksanakan di SD Negeri 104/II Sungai Pinang mendapat respon baik dari Kepala sekolah dan majelis guru SD Negeri 104/II Sungai Pinang. Melalui kegiatan pengabdian ini diharapkan dapat menciptakan penerapan sejak dini tentang nilai-nilai dampak dari kekerasan seksual pada siswa SD Negeri 104/II sungai pinang khususnya dan SD yang ada di Muara Bungo pada umumnya.
Pelatihan Pembuatan Abon Lele Sebagai Nilai Tambah Perekonomian dan Diversifikasi Pangan di Kota Malang
Authors: Meiji Nanda Harda Pratama , Kodir Abdul , Purnama Emilia Putri , Widianto Faizal Gustian , Putra Egi Baskara
Published: March 2023

Pandemi membuat banyak perubahan dalam konteks kehidupan bermasyarakat. Oleh karena itu diperlukan Kerjasama yang berkesinambungan untuk memulihkan kondisi sosial ekonomi masyarakat. Tujuan dari pengabdian yaitu menghasilkan produk olahan abon lele dan sistem manajemen usaha masyarakat untuk penjualan secara meluas. Metode yang diterapkan dalam pengabdian ini adalah metode Training of Trainer (ToT) dengan cara melakukan pemberian materi melalui ceramah sekaligus memberikan praktik langsung bersama masyarakat. Selain itu diberikan kegiatan pendampingan kepada masyarakat, dengan Langkah yang meliputi Identifikasi Potensi Lokal; Persiapan Kegiatan; Sosialisasi Kegiatan; Pelaksanaan Kegiatan; Monitoring dan Evaluasi; serta Publikasi. Hasil dari pengabdian ini masyarakat RT 06 dan 10 Kampung Mergan Sekolahan mampu menghasilkan produk olahan Abon Lele yang telah dipublikasikan dalam acara yang diselenggarakan oleh Diskoperindag Kota Malang.
Pelatihan Pengembangan Multimedia Interaktif Berbasis Android pada Mata Pelajaran di SDN
Authors: Mudeing  , Thahir Irmawati , Rauddin  , Syam Nurmadina
Published: March 2023

Pengembangan media pembelajaran multimedia interaktif dengan memakai smarphone dan sejenisnya memiliki dampak positif pada aspek kognitif, emosional, dan sosiokultural anak dikarenakan mampu mentransformasikan pengalaman belajar. Dengan menggunakan multimedia pembelajaran siswa dapat belajar kapanpun dan dari mana saja dengan menggunakan software berupa aplikasi yang disajikan secara interaktif dan menarik minat belajar pesrta didik. Salah satunya multimedia pembelajaran berbasis Android yang dapat dikembangkan adalah powerpoint yang dikemas dalam bentuk aplikasi Android dengan alat bantu aplikasi IspirinSite untuk menjadikan multimedia yang dibuat dalam bentuk android yang dikembangkan oleh pendidik. Aplikasi ini berisi materi pembelajaran berserta kuis yang dapat dipelajari peserta didik secara mandiri tanpa bantuan guru. Aplikasi ini menggunakan ponsel berplatform android. Tujuan pengabdian ini dilakukan adalah untuk membuat produk berupa multimedia pembelajaran interaktif berbasis android dengan menggunakan software powerpoint, dan mengedukasi pendidik terhadap penggunaan aplikasi android dan pengambilan keputusan siswa. Berbasis media pembelajaran melalui aplikasi powerpoint untuk pembelajaran. Pengabdian ini menggunakan metode pelatihan, analis peserta didik, desain multimedia, pengembangan multimedia dan revisi.
Cervical Myelopathy Induced by Posterior Vertebral Body Osteolysis after Cervical Disc Arthroplasty
Authors: Choi Man Kyu , Lee Jun Ho
Published: March 2023

Cervical disc arthroplasty (CDA) has become more widespread and diverges from the conventional technique used in anterior cervical fusion for cervical degenerative disc disease. As arthroplasty has become a popular treatment option, few complications have been reported in the literature. These include subsidence, expulsion, posterior avulsion fractures, heterotopic ossification, and osteolysis. One of the critical complications is osteolysis, but current studies on this subject are limited in terms of not elucidating the incidence, etiology, and consequences. The authors present two cases, who presented with clinical signs of gradually worsening myelopathy induced by posterior vertebral body osteolysis, 2 years after CDA. Subsequently, the patient underwent posterior decompression and fusion without prosthesis removal. Postoperatively, the clinical symptoms gradually resolved, with no severe deficits. The present rare cases highlight the osteolysis that occurs after CDA, which can cause cervical myelopathy, and suggest spine surgeons to be alert to this fatal complication.
Cooperative of Team Games Tournament to Enhance Learning Outcomes in English Learning
Authors: Yusuf Faidah , Usman Hikmawati , Irfan Muhammad , Aras Latri , Rahman Hardianto
Published: March 2023

The challenge of teaching English to students with low academic achievement is what inspired this line of inquiry. The purpose of this research was to provide an explanation of how the Team Games Tournament was implemented Elementary class in order to improve the English learning outcomes of the pupils. The type of action research that was conducted in the classroom for the purpose of this study was approached from a qualitative point of view. A total of 24 students took part in this research project, both as instructors and as research subjects. As means of collecting data for the purpose of this investigation, observation reports, learning progress examinations, and documentation were utilized. The findings of the research are that the implementation of the Team Games Tournament was generally carried out in an effective manner. Less teacher activity was recorded during Cycle I Meeting I, which sufficient category, however, more teacher activity was recorded during Meeting II, which rated as "good." Because of this, the student's results in learning English have iincreased. The implementation of the Team Games Tournament learning model in an educational of elementary school to improve the learning outcomes for students has been shown to be beneficial.
Approaches and Methods to Teaching Grammar in Textbooks Used in First Semester of English Department Students at ABA Balikpapan
Authors: Rochman Muhammad
Published: March 2023

This study aims to describe, compare, and contrast approaches and methods to teaching grammar in textbooks used in First Semester of English Department Students at ABA Balikpapan. It chooses, as samples for analysis, textbooks of one particular class to focus on the approaches to teaching grammar in these textbooks. These textbooks are taught for first intermediate class and belong to two different series titled First Semester of English Department Students at ABA Balikpapan opportunities and English for First Semester of English Department Students at ABA Balikpapan. Each of these textbooks follows essentially different approaches to teaching grammar. This study aims to highlight the similarities and differences between the books and reveals the weaknesses and strengths of the approaches in these books. The purpose of the study is changing these textbooks and to reveal the similarities and differences between the old and new textbooks. The data collection method of this research is the collation texts for analysis. The information is breaking down subjectively and quantitatively. The study considerably contributes to the field of language teaching in First Semester of English Department Students at ABA Balikpapan especially grammar teaching through drawing attention of language lecturers, textbook writers, as well as learners to a certain degree, to the weaknesses and strengths of the PPP method (Presentation Practice Production)  in the First Semester of English Department Students at ABA Balikpapan opportunities textbook and task-based approach in the English for First Semester of English Department Students at ABA Balikpapan textbook.
Students’ Perspectives on Their Writing Skills and The Application of Process Writing Approach in the Academic Writing Classroom
Authors: Marantika I Made Yogi , Tustiawati Ida Ayu Mela
Published: March 2023

This paper describes the result of student self-reflection on their writing ability and the application of the process writing approach conducted in their academic writing class. The data was collected through a self-reflection written by the participants. The students were guided to reflect on their learning experience in two aspects: their views on their writing ability and the application of the process writing approach in the classroom. Forty-four students of the English literature program from the Faculty of Foreign Languages, Mahasaraswati Denpasar University, were chosen as the participants for this study through a purposive sampling method. This method was ideal because these students have undergone similar learning experiences within the same context, which provided rich data for the study. The result of their self-reflection was analysed using a qualitative approach. The findings indicate that more than half of the participants perceived their writing ability as lacking. Less than 10% of the participants were confident in their writing ability, and the rest saw improvement in their ability but required further practice and guidance. In terms of the application of process writing, the majority of participants agreed that it had a positive impact on their writing process.
The Causes of Code Switching and Code Mixing by Low Level of EFL Learners
Authors: Halwiyah Halwiyah , Oktaviana Fadilla , Hendra Hendra
Published: March 2023

The objective of this study is to analysis the proses occurred the code switching and code mixing, to find out the types and the cause seventh grades at SMPN 1 KIBIN. This study was categorized into qualitative research design embracing particularly the content analysis. The data in this thesis were collected through observation, transcript conversation and documentation. In analysing the data the writer used triangulation data that consist of data reduction, data display and conclusion drawing/verification. The conclusion for this thesis is that in the conversation in seventh grades at SMPN 1 KIBIN occurred code switching and code mixing with the result of this thesis showed that each have three types of code switching and code mixing used in seventh grade at SMPN 1 KIBIN. (1) The calculation of the percentage code switching, the highest percentage results above are intra sentential switching (52%) because in this type of students are able to say words in English. The ssecond percentage is inter sentential switching (36%)  not much different from the previous type, but in this type there are no explanatory sentences after or before. And the last smallest percentage is tag switching (12%) only one student does this type. (2) The calculation of the code mixing percentage, the highest percentage results above are alternation approaches (50.98%), students are able to speak explanatory sentences. The second in this percentage are insertions (word phrases) ( 33.33%) because in this type of students are able to say words in English. And the last, the smallest percentage is congruent lexicalization (dialect) (15.68%) only two students who do this type.
Measuring the impact of employment on persons with a disability as a means of improving the quality of employment outcomes
Authors: Smith Peter , Parmenter Trevor
Published: March 2023

Aim: Current measures for disability employment focus on system outputs, not individual outcomes. This paper proposes an employment outcome measurement approach based on social quality theory as a means of improving the quality of employment outcomes for individuals.
Introduction: There is a paucity of government policies that promote practices which address the measurement of employment outcomes that reflect the goals of the individual. While there has been a recent trend towards a focus on quality of life as an outcome, process measurement and compliance to procedural regulations are still dominant.
Method: A scoping review of disability employment research from the year 2000 revealed only eleven papers which specifically addressed approaches to measuring disability employment outcomes at an individual impact level. Overall, the search failed to highlight any measure that focused on the impact of employment on the individual with existing measures focused on process measurement.
Conclusion: An outcomes-based approach, based on the four pillars of social quality theory, namely, social inclusion, social cohesion, self-determination, and social-economic security provide an opportunity to shift disability employment service provision towards individual outcomes rather than its existing focus on system outputs as a measure of success.
Experience, Thoughts, and Attitudes of Orthopaedic Surgeons about Chronic Postsurgical Pain after Arthroplasty
Authors: BALTA Selin , GÜLTEKİN Muhammet Zeki
Published: March 2023

Objective: Arthroplasty constitutes a major procedure commonly used in orthopaedic and traumatology surgery, and chronic pain develops in 7%–34% of patients after arthroplasty. This study aims to evaluate the experience, thoughts and attitudes of orthopaedic surgeons about chronic postsurgical pain after arthroplasty.

Methods: The survey was sent to orthopaedic surgeons via the Google survey system. The questionnaire consisted of 17 questions in total; four were related to demographic information, two asked about the surgeons’ experience, three asked for their thoughts, and eight queried their attitudes.

Results: The study evaluated 319 participants. All the orthopaedic surgeons reported that they routinely prescribe for postoperative pain control when discharging patients after arthroplasty. Of those surveyed, 69.7% have used multimodal analgesic therapy to treat chronic postsurgical

pain after arthroplasty. Consultation rates were 5% and 20% for psychiatry and pain physician, respectively. A weak positive correlation was

found between the rate of referring patients with chronic postsurgical pain after arthroplasty to pain physician and the beliefs of orthopaedic surgeons that pain physician can help patients with chronic postsurgical pain after arthroplasty who are unresponsive to pharmacological treatments (p = 0.008, r = 0.148).

Conclusion: Orthopaedic surgeons employ pre-emptive approaches to chronic postsurgical pain after arthroplasty and engage in pharmacological management of chronic postsurgical pain after arthroplasty, but they need to advance further with multidisciplinary treatments and directions.
The Relationship Between Somatization and Depression Types: Comparison of Unipolar Depression and Bipolar Depression
Authors: AKÇA Erdoğdu , DEMİROK AKÇA Zeynep Nur , YILDIZ Mesut
Published: March 2023

Objective: Somatic symptoms are more likely to be present in depression and anxiety, which causes to waste medical resources due to excessive hospital addmissions. It has been observed that the unclarity of qualitative and quantitative characteristics of somatization depending on the type of depression influences clinical practice less than expected. In the present study, it was aimed to determine the hallmarks of somatic symptoms in depression groups and to investigate the factors that might have an effect on somatic symptoms.

Method: One hundred consecutive patients (50 with Bipolar Depression (BD), 50 with Unipolar Depression (UD)) who met the criteria participated in the study. Patients were assessed for depressive symptoms with Montgomery Asberg Depression Scale and for somatic symptoms with Bradford Somatic Symptom Inventory. Clinical features were obtained by the clinician via Sociodemographic Data Form.

Results: It was found that no significant difference in somatization characteristics between the depression groups. (p> .05). Somatic symptom severity was higher in the UD group in the presence of psychiatric comorbidity (p= .013), but not in BD. Another prominent finding was that the severity of depression was noted the only predictor of severe somatization.

Conclusion: The results show that increased somatic symptoms are associated with the severity of depression, suggesting treatment of depression with somatization rather than differential diagnosis should be primary concern.
RANCANG BANGUN APLIKASI BELAJAR ARAB UNTUK ANDROID MENGGUNAKAN JETPACK COMPOSE DAN KOTLIN
Authors: Dzulqarnain Fahmi , Tukino Tukino
Published: March 2023

Indonesia has the world's largest Muslim population, so learning Arabic is quite important and is widely practised throughout the country. However, learning Arabic is often done with less efficient and effective methods due to the problem of language differences that are quite far from the Indonesian Language. These differences can be seen in sound or phonetic systems, letters, grammar, and vocabulary management. This research was conducted with the aim of designing and building a system in the form of a simple language game with self-dictionary to overcome the problems faced by Indonesians who have or will learn Arabic. This Arabic learning app will be designed to be interactive and fun for Arabic learners in Indonesia with the default app instruction language also using The Indonesia Language. The design method will use the Agile method. The result of designing and building this Arabic Learning app is successful because all of the feature test conducted has been passed.
ANALISIS USABILITY PADA APLIKASI ALINGKA MENGGUNAKAN METODE COGNITIVE WALKTHROUGH
Authors: Fadila Aprilina Ajeng , Azrino Gustalika Muhamad
Published: March 2023

Perkembangan saat ini mengemban misi untuk mencapai inovasi melalui pemanfaatan teknologi. Teknologi ini membuat interaksi antara pemerintah dan warga lebih mudah diakses. Kehidupan teknologi memaksa Kota Baubau menciptakan software ALINGKA yang dapat membantu masyarakat dalam situasi darurat. Keberhasilan perangkat lunak Anda dapat ditentukan oleh pengujian kegunaan. Padahal, aplikasi ini belum diuji. Usability testing adalah untuk mengetahui sejauh mana aplikasi ALINGKA dapat berjalan dengan baik. Tujuannya untuk mengetahui hasil penerapan ALINGKA dengan metode cognitive walkthrough, dan memberikan rekomendasi perbaikan. Data responden dikumpulkan dengan kuesioner. Responden dalam penelitian ini adalah masyarakat Kecamatan Wolio Kota Baubau yang diperoleh menurut rumus Taro Yamane, kemudian disaring menggunakan purposive sampling sesuai dengan kriteria yang telah ditentukan sehingga diperoleh 15 responden tertentu. Diperoleh dengan menghitung tingkat keberhasilan sebesar 84% yang merupakan rata-rata tingkat keberhasilan situasi kerja responden. Responden menghabiskan waktu mengerjakan skenario tugas yang dihitung menggunakan waktu untuk menyelesaikan tugas dengan laju 0,118 gol/detik. Perhitungan dari penelitian ini menunjukkan bahwa dari segi kegunaan aplikasi ALINGKA masih banyak menu aplikasi yang perlu diperbarui.
Systematic analysis of cell morphodynamics in C. elegans early embryogenesis
Authors: Azuma Yusuke , Okada Hatsumi , Onami Shuichi
Published: March 2023

The invariant cell lineage ofCaenorhabditis elegansallows unambiguous assignment of the identity for each cell, which offers a unique opportunity to study developmental dynamics such as the timing of cell division, dynamics of gene expression, and cell fate decisions at single-cell resolution. However, little is known about cell morphodynamics, including the extent to which they are variable between individuals, mainly due to the lack of sufficient amount and quality of quantified data. In this study, we systematically quantified the cell morphodynamics in 52 C. elegansembryos from the two-cell stage to mid-gastrulation at the high spatiotemporal resolution, 0.5 μm thickness of optical sections, and 30-second intervals of recordings. Our data allowed systematic analyses of the morphological features. We analyzed sphericity dynamics and found a significant increase at the end of metaphase in every cell, indicating the universality of the mitotic cell rounding. Concomitant with the rounding, the volume also increased in most but not all cells, suggesting less universality of the mitotic swelling. Combining all features showed that cell morphodynamics was unique for each cell type. The cells before the onset of gastrulation could be distinguished from all the other cell types. Quantification of reproducibility in cell-cell contact revealed that variability in division timings and cell arrangements produced variability in contacts between the embryos. However, the area of such contacts occupied less than 5% of the total area, suggesting the high reproducibility of spatial occupancies and adjacency relationships of the cells. By comparing the morphodynamics of identical cells between the embryos, we observed diversity in the variability between cells and found it was determined by multiple factors, including cell lineage, cell generation, and cell-cell contact. We compared the variabilities of cell morphodynamics and cell-cell contacts with those in ascidianPhallusia mammillataembryos. The variabilities were larger inC. elegans, despite smaller differences in embryo size and number of cells at each developmental stage.
A computational framework for testing hypotheses of the minimal mechanical requirements for cell aggregation using early annual killifish embryogenesis as a model
Authors: Montenegro-Rojas Ignacio , Yañez Guillermo , Skog Emily , Guerrero-Calvo Oscar , Andaur-Lobos Martin , Dolfi Luca , Cellerino Alessandro , Cerda Mauricio , Concha Miguel L. , Bertocchi Cristina , Rojas Nicolás O. , Ravasio Andrea , Rudge Timothy J.
Published: March 2023

Introduction: Deciphering the biological and physical requirements for the outset of multicellularity is limited to few experimental models. The early embryonic development of annual killifish represents an almost unique opportunity to investigate de novo cellular aggregation in a vertebrate model. As an adaptation to seasonal drought, annual killifish employs a unique developmental pattern in which embryogenesis occurs only after undifferentiated embryonic cells have completed epiboly and dispersed in low density on the egg surface. Therefore, the first stage of embryogenesis requires the congregation of embryonic cells at one pole of the egg to form a single aggregate that later gives rise to the embryo proper. This unique process presents an opportunity to dissect the self-organizing principles involved in early organization of embryonic stem cells. Indeed, the physical and biological processes required to form the aggregate of embryonic cells are currently unknown.

Methods: Here, we developed an in silico, agent-based biophysical model that allows testing how cell-specific and environmental properties could determine the aggregation dynamics of early Killifish embryogenesis. In a forward engineering approach, we then proceeded to test two hypotheses for cell aggregation (cell-autonomous and a simple taxis model) as a proof of concept of modeling feasibility. In a first approach (cell autonomous system), we considered how intrinsic biophysical properties of the cells such as motility, polarity, density, and the interplay between cell adhesion and contact inhibition of locomotion drive cell aggregation into self-organized clusters. Second, we included guidance of cell migration through a simple taxis mechanism to resemble the activity of an organizing center found in several developmental models.

Results: Our numerical simulations showed that random migration combined with low cell-cell adhesion is sufficient to maintain cells in dispersion and that aggregation can indeed arise spontaneously under a limited set of conditions, but, without environmental guidance, the dynamics and resulting structures do not recapitulate in vivo observations.

Discussion: Thus, an environmental guidance cue seems to be required for correct execution of early aggregation in early killifish development. However, the nature of this cue (e.g., chemical or mechanical) can only be determined experimentally. Our model provides a predictive tool that could be used to better characterize the process and, importantly, to design informed experimental strategies.