bluuebunny/crossref_metadata_2025 huggingface dataset:
La perspectiva de género como factor del desarrollo urbano sostenible en la práctica judicial
Authors: Montalbán Huertas Inmaculada
Published: October 2024

Este trabajo analiza la evolución de la jurisprudencia del Tribunal Supremo, en relación con los efectos del trámite de emisión del informe de impacto de género en los instrumentos de planificación territoriales y urbanísticos. Abordará el punto de inflexión que supone la STS 1750/2018, de 10 de diciembre. En ella se afirma que el principio de igualdad de género no es una cuestión neutral en urbanismo; y, lo que es especialmente trascendente para la práctica judicial, concluye que no es necesario el sometimiento del plan a un trámite específico para que la perspectiva de género deba ser tenida en cuenta y para que los planes puedan ser impugnados y controlados judicialmente desde tal perspectiva.
El derecho de los menores a una justicia adaptada a la infancia. Experiencia del juzgado especializado en violencia contra la infancia
Authors: Rincón Acereda Mónica
Published: October 2024

El juzgado especializado en violencia contra la infancia y la adolescencia es una experiencia piloto del Consejo General del Poder judicial, puesta en marcha en el partido judicial de Las Palmas de Gran Canaria en octubre de 2021, con previsión de 2 años de funcionamiento. Entre los objetivos prioritarios del juzgado se encuentra poner en marcha estrategias que favorezcan una justicia accesible, centrada en las personas menores y amigable hacia los niños y las niñas. Se mencionan brevemente el marco normativo y las directrices sobre justicia adaptada a la infancia, el funcionamiento, características y resultados preliminares de los asuntos tramitados durante el primer año, así como el papel de la psicología forense en la valoración pericial de menores víctimas de violencia intrafamiliar física o sexual. Asimismo, se analizan las características de aquellos procedimientos en los que se presentan denuncias previas en el mismo o distinto orden jurisdiccional y sus implicaciones psicológico-forenses.
El derecho administrativo español en Iberoamérica: retos y desafíos actuales
Authors: Rodríguez-Arana Muñoz Jaime
Published: October 2024

La presencia del derecho público en América se remonta a finales del siglo XV y, desde entonces, ha dado lugar a un sistema jurídico que, con el tiempo, llegó a superar en humanismo al ordenamiento español. Respecto de esta realidad, tres son los aspectos clave en el actual contexto: la influencia de la Constitución española de 1978 en América, los cambios que deben producirse en las Administraciones públicas de Iberoamérica y el sentido y funcionalidad de la Carta Iberoamericana de los Derechos y Deberes del Ciudadano en Relación con la Administración Pública.
El control de la sumisión a arbitraje: una revisión del principio favor arbitrandum
Authors: Sánchez Lorenzo Sixto
Published: October 2024

El principio favor arbitrandum se formula en el arbitraje como una petición de principio en relación con la eficacia del acuerdo arbitral. Esta ponencia trata de delimitar los supuestos en los que dicho principio es susceptible de aplicación por los órganos jurisdiccionales en apoyo o control del arbitraje y se decanta, en determinados supuestos, por un principio opuesto, partidario de una interpretación restrictiva de la eficacia del acuerdo arbitral, en la medida en que conlleva una renuncia a la tutela judicial.
Teacher Evaluation Program Based on Students’ Ratings: The Effects of Students’ Grades
Authors: Mascaro Guillermo , Alba Enrique
Published: October 2024

This investigation tested the effects of exam grades received by students on the students’ evaluations of their professors. In accord with predictions based on reinforcement and on adaptation-level theory, it was found that changes In evaluative ratings given by students to a teacher were significantly related to the students’ “obtained grades” and to the students’ “relative grades” (i.e., ratio of obtained grade to expected grade).
1,001 handshakes
Authors: Lapointe François-Joseph ,   École nationale supérieure des Arts Décoratifs Paris
Published: October 2024

I inhabit the microbial world. Microbes live on my body and inside my body. Every opening in my body envelope is populated by millions and millions of different microbes. I eat microbes, swallow microbes, digest microbes, and defecate microbes. When I kiss my wife, I share microbes with her. When I shake hands with my neighbor, we swap our microbes. We are both part of a complex network of microbes commonly referred to as the microbiome, which is an essential part of our individual and collective bodies. The composition of my microbiome fluctuates on a daily basis, according to my all my actions and encounters. Although my genome is fixed, my microbiome is changeable and adaptable. I can transform my microbiome as I wish to change my identity. As part of my artistic practice, I expose my own body to various types of experiments aimed at changing the makeup of my microbiome. I then use the tools of science to quantify the effects produced.

On February 3, 2016, I shook hands with 1,001 people at the Berlin Transmediale, gradually transforming the invisible community of microbes living in the palm of my right hand. At regular intervals, assistants took samples of this skin microbiome to study how contact with others transforms who we are. Since then, I have repeated this hybrid project, at the interface of art and science, in Copenhagen, Montreal, Perth, San Francisco, Baltimore, and Paris. The performance of 1,001 handshakes raises awareness through physical engagement, through acts of participation and exchange at the social, individual, and microbial levels. As a scientist, the objective of this experiment was to collect scientific data on the human microbiome, the dynamics of contamination of my microbiome in contact with the microbiome of others. As a bioartist, it was more the notion of individuality that appealed to me, a philosophical concept that I formalize through microbiome self-portraits, or microbiome selfies generated from the DNA of bacteria harvested from the palm of my hand. Hidden beyond the visible, in the palm of a hand, as the most curious visitors zoom in, these microbiome selfies reveal themselves on a micro scale. Am I still the same after a thousand handshakes with strangers? These multicolored bacterial networks attest to my metamorphosis.

This mundane action of the handshake comes to us today in a new light amidst a global pandemic exacerbated by social distancing. The limits of my body are not those of my skin. I touch therefore I am. I carry traces of your microscopic identity with me. I am a network of microbial cells that dance with my own cells to construct the person that I am in real time.
Trasplante de órganos: ¿Hacia dónde vamos?
Authors: Alfaro Varela Julio César
Published: October 2024

Hablar de donación y trasplante de células, tejidos y órganos en la época actual es de suma relevancia, especialmente con los cambios en la actual ley de donación que hay en El Salvador. Para poder comprender de manera adecuada esta temática hay que definir ciertos conceptos básicos. Los conceptos son los siguientes: Donación: es el acto de remover quirúrgicamente un órgano que cede voluntariamente una persona para salvar o mejorar la calidad de vida de una o varias personas. Trasplante: es el acto de trasladar un órgano, tejido o conjunto de células de una persona (donante) a otra (receptor).
STUDI POTENSI BIOMASSA HUTAN SAGU (Metroxylon Sp) DI DESA TULEHU KECAMATAN SALAHUTU KABUPATEN MALUKU TENGAH
Authors: Haduaci Doni , Mardiatmoko Gun , Pattimahu Debby
Published: October 2024

Sago forests (Metroxylon sp) in Tulehu Village, Salahutu District, Central Maluku Regency are one of the staple food sources of the Maluku community that have been consumed for generations. Various parts of sago from leaf stalks to trunks have been widely studied. However, research related to sago biomass has not been done much. In this regard, this paper aims to determine the potential biomass and carbon reserves stored in sago forests in Tulehu Village for the purposes of handling climate change. The biomass and carbon content reserves to be determined are sago at the pole and tree levels. The method used was 3 survey routes with 30 measurement plots using purposive sampling, observation, then analysis and estimation of biomass and stored carbon reserves. The calculation results at the pole level of sago obtained a biomass of 27 tons/ha and stored carbon reserves of 14 tons/ha. At the tree level of sago, a biomass of 42 tons/ha and stored carbon reserves of 20 tons/ha were obtained.
KARAKTERISTIK KIMIA DAN ORGANOLEPTIK JELLY DRINK FILTRAT DAUN KELOR YANG DITAMBAHKAN GELATIN
Authors: Bernard Rianty , Lopulalan Cynthia G. Christina , Picauly Prisylia
Published: October 2024

Tropical plants that have health benefits are moringa plants. Moringa is currently the most widely consumed food. The aim of this study was to analyze the chemical and organoleptic characteristics of moringa leaf extract jelly drinks processed with gelatin concentrate. The design used was a Randomized Design (CRD) with gelatin concentration treatments of 30, 40 and 50%, 3 replications. The results obtained were that the higher the concentration of gelatin had a significant effect on fiber, vitamin C and dissolved solids content, and reduced water content. The results of the organoleptic test showed that the three treatments did not provide a significant effect between treatments.
BERAT POTONG AYAM BROILER YANG DIBERI EKSTRAK KUNYIT PUTIH (Curcuma zedoaria) DENGAN DOSIS YANG BERBEDA SECARA ORAL
Authors: Tuarita Hejer , Ralahalu Tabita naomi , Patty Christian
Published: October 2024

This research was conducted to determine the effect of oral administration of white turmeric extract (Curcuma Zedoaria) at different levels on the slaughter weight of broiler chickens. This research will take place for 3 months, August – October 2023 at the Faculty of Agriculture, Department of Animal Husbandry, Livestock Unit, Pattimura University, Ambon. Completely Randomized Design (CRD) was used in this study with 4 replications and 4 treatments, the replications consisted of 6 chickens.  The treatments applied were P0 = feed without giving turmeric extract (control), P1= feed + turmeric extract 0.7 ml/head, P2= feed + turmeric extract 1.4 ml/head, P3= feed + turmeric extract 2.1 ml /tail. The variables observed were feed consumption and slaughter weight.  The results of the research conducted showed that oral administration of white turmeric extract had no significant effect (P > 0.05) on feed consumption and slaughter weight of broiler chickens. However, numerically the administration of white turmeric extract resulted in a higher increase in the slaughter weight of broiler chickens compared to the slaughter weight of broiler chickens without the administration of white turmeric extract.
METODOLOGIA BIM NA GRADUAÇÃO DE ARQUITETURA E URBANISMO: UMA ANÁLISE DAS MATRIZES CURRICULARES DAS INSTITUIÇÕES PRESENCIAIS DE VITÓRIA DA CONQUISTA – BA
Authors: Bastos Maria Luísa Pereira , David Alline Maria Trancoso Ferraz Silva
Published: October 2024

This study addresses the importance of introducing the BIM (Building Information Modeling) methodology into the Architecture and Urbanism undergraduate curriculum, considering the continuous transformations in the construction sector. Given the growing need for adaptation to new market demands, it is essential that future architects are qualified to integrate practices that promote greater agility and efficiency in project development. The research adopts a qualitative approach, using bibliographic, to demonstrate the relevance of teaching BIM from the academic stage. The study highlights how this innovative methodology not only prepares students for professional challenges but also significantly enhances their performance in the job market. The inclusion of BIM in the educational environment is identified as a competitive advantage, allowing for a deeper understanding of the design and execution phases, as well as fostering more efficient integration between the various actors involved in the construction process. Thus, this study reinforces the need for curricular reform that incorporates BIM as an essential component of the training of architects and urban planners.
Hipomelanismo en la tortuga jicotea de agua Trachemys venusta
Authors: Rosales-Martinez Carlos Santiago , Silva-Molina Francisco Javier , Cupul-Magaña Fabio Germán
Published: October 2024

The Mesoamerican Slider Trachemys venusta ocurr from several Central American countries to Mexico. The first case of hypomelanism in a captive-born specimen is formally reported. In this chromatic aberration or pigmentary anomaly resulting from genetic factors, the dark tones of specimen’s body with carapace length 77 mm and undetermined sex, were observed pale (discolored), except for the eyes which retained normal coloration, were the patterns of lines and ocelli in yellow and green tones also persisted. Additionally, the plastron exhibited a lighter yellow hue compared to the typical coloration. In the wild, such color abnormalities can be considered a disadvantage as they contrast with the specimen in aqueous murky environments, making it more susceptible to detection and predation compared to specimens with normal coloration.
Artificial Intelligence in Academic Libraries: Applications and Impact Review
Authors: Mandal Moumi
Published: October 2024

The field of artificial intelligence (AI) has opened up new opportunities for advancing research across the board. The future seems bright since artificial intelligence technologies are present in every aspect of business. The supply and use of library information resources as well as the accomplishment of the library's aims and objectives have benefited greatly from the use of AI. An overview of the literature on the use of artificial intelligence (AI) in libraries and its effects is given in this article. The goal of this project is to provide scholars with a thorough grasp of artificial intelligence in the context of libraries. This paper investigates the possibilities of AI in academic libraries, emphasizing advantages like increased effectiveness, better accessibility, and customized user experiences. Even if AI has drawbacks like algorithmic bias, data privacy, and ethical concerns, it also has advantages like growth and innovation potential. In order to effectively incorporate AI into library services in India, the study highlights the need for librarians to educate themselves, experiment with AI technologies, and keep updated about developing trends.
News Broadcasting Media and Misinformation: an Assessment of Viability of Various Regulatory Mechanisms in India
Authors: Choudhary Ishika , Mishra Asish
Published: October 2024

In recent times, India is not only dealing with pandemic of Covid-19 but also dealing with another kind of pandemic which is far more dangerous to the citizens of India. And, still there is no progress made to prevent this another kind of pandemic which is brought in the nation by news broadcasting media with the virus of “misinformation”. In democratic country news media plays important role as it is considered as fourth pillar of democracy, but nowadays, it is seen that news media houses are more interested in giving misinformation to make their news content more sensational and to promote indirectly political parties’ agendas. And, the self-regulatory mechanism is failing to maintain the ethical standards required in such profession. This paper attempts to analyze various regulatory mechanism to see best possible mechanism to prevent this pandemic. In this research paper doctrinal and descriptive research methodologies have been used. And it can be concluded that more balanced and co- regulatory mechanism can be most feasible to held responsible news media houses and to bring the standard ethical values which are required in this profession.
Analisa Kepuasan Pelanggan Terhadap Pelayanan di Toko XX di Gunungsitoli
Authors: Zebua Yesni Anggraini
Published: October 2024

Customer satisfaction is an important indicator in evaluating business success. Toko XX in Gunungsitoli has the responsibility to ensure that customers are satisfied with their services. This study uses a quantitative method with a survey approach and the SERVQUAL model to measure customer satisfaction. A sample of 385 respondents was randomly selected. The results of the study show that customers are generally satisfied, with 60% giving a rating of 4 (satisfied) and 20% giving a rating of 5 (very satisfied). The dimensions of reliability and responsiveness have a significant impact on customer satisfaction, while the dimensions of tangibles and empathy need improvement. These findings provide insights for Toko XX to improve service quality and customer satisfaction
Med tingene som landemerker
Authors: Østrem Arild Julius
Published: October 2024

I denne artikkelen undersøker jeg hvordan fysiske gjenstander i barnehagen kan påvirke barns interaksjoner og relasjoner med hverandre. Jeg tar utgangspunkt i feltnotater fra deltakende observasjon og undersøker et utdrag fra materialet hvor barn er opptatt av en navngitt trehjulssykkel. Materialet er analysert i lys av begreper fra Hannah Arendt, med vekt på Arendts begrep om verden. I denne analysen vektlegges relasjonene mellom mennesker, mens omgivelsene forstås som fundamentet for disse relasjonene. Studien viser at barna bruker navngitte og unike ting i utforskning og etablering av relasjonell identitet. Jeg argumenterer for at trehjulssyklene i feltnotatutdraget fungerer som unike landemerker som barna bygger sine relasjoner på.AbstractThings as landmarks – the meaning of objects in children’s peer relations in kindergarten.In this study I examine how physical objects in preschool can play a part in children’s interactions and relations with each other. Using field notes from participant observation, I examine an excerpt where the children are oriented towards a named tricycle. The data is analysed using terms from theorist Hannah Arendt and her concept of the world. The analysis emphasizes the relation between people, while their surroundings are understood as the foundation for these relationships. The study shows that the children use named and unique items in their exploration and establishment of a relational identity. I argue that the tricycles in the field notes function as unique landmarks, on which the children base their relations.
Bevægelsespraksisser i dagtilbud
Authors: Lund Ole , Blume Michael , Jensen Jens-Ole
Published: October 2024

Med afsæt i en empirisk undersøgelse analyserer artiklen, hvilke bevægelsespraksisser der er til stede i dagtilbud. I artiklen anvendes et bevægelsesbegreb der tilstræber at balancere mellem en opfattelse af, at alt er bevægelse, fx at trække vejret, og snævre forståelser som betragter bevægelse som regelbaserede idrætsaktiviteter eller som ren og skær fysisk aktivitet. Artiklen foreslår tre overordnede måder at forstå bevægelsespraksisser i dagtilbud på. Det handler om funktionel, struktureret og “fri” bevægelse. De tre kategorier bliver diskuteret i forhold til tre formålsdomæner, som Gert Biesta foreslår, at al pædagogik og uddannelse bør orientere sig imod. Hensigten hermed er at komme nærmere en forståelse af, hvordan pædagogisk personale kan arbejde med bevægelse indenfor de tre kategorier på en meningsfuld måde både for børnene og dem selv.AbstractMovement practices in daycareBased on an empirical investigation, the article investigates movement practices in Danish day care. The article’s concept of movement aims to balance between a broad understanding of movement as everything, e.g. breathing, and narrow understandings, which consider movement as rule-based and sport-like activities or as sheer physical activity. The article proposes three general ways of understanding movement practices in day care: functional, structured and “free” movement. The three categories are discussed against three educational domains, which Gert Biesta suggests is involved in all pedagogy and education to varying degrees. The aim is to better understand how educators can work with movement within the three categories in a way that is meaningful to both children and educators themselves.
Nuevos retos tras 25 años de historia: microcredenciales, formación dual e IA
Authors: Sanz Martos Sandra
Published: October 2024

El Día Mundial de las y los Docentes se celebra el 5 de octubre desde 1994 como conmemoración del aniversario de la suscripción de la Recomendación de la UNESCO relativa a la situación del personal docente. Esta Recomendación establece criterios de referencia en cuanto a los derechos y responsabilidades del personal docente y normas para su formación inicial y perfeccionamiento, la contratación, el empleo, y las condiciones de enseñanza y aprendizaje. Es un día para celebrar el modo en que los profesores están transformando la educación, reflexionar sobre el apoyo que necesitan para desplegar plenamente su talento y vocación, y repensar el camino que queda por delante con respecto a la profesión a nivel mundial.
Моделирование течения воздуха в упруго-деформируемой пористой среде, аппроксимирующей легкие человека: алгоритм реализации и анализ результатов применения модели
Authors: Трусов Петр Валентинович , Зайцева Нина Владимировна , Цинкер Михаил Юрьевич , Нурисламов Владислав Владимирович
Published: October 2024

The work is devoted to the implementation of the mathematical model of the human respiratory system developed by the authors to predict the occurrence of respiratory pathologies caused by the negative effects of atmospheric air pollution. The proposed model describes human lungs as an elastically deformable saturated two-phase porous medium with large displacement gradients. Since the analytical solution of the formulated essentially nonlinear problem seems unfeasible, it is suggested that the solution can be obtained by applying numerical methods with step-by-step procedures. An algorithm is proposed for solving the related problem of air filtration in an elastic deformable porous medium. The nonlinear sub-problem of deformation of a two-phase lung medium is solved numerically by finite element method, and the filtration subproblem — by finite volume method. A set of programs was developed (in the C++ programming language) using parallel computing technologies to implement the algorithm. Based on the tomographic images of the lungs obtained with the ITK-SNAP software package, the three-dimensional shape of the lungs was reconstructed. Using the engineering software ANSYS ICEM CFD, a volumetric finite element mesh was constructed. Numerical modeling of air flow in the human lungs was performed for personalized three-dimensional geometry. The pressure fields of the gas phase in the human lungs at various moments of the respiratory cycle are presented. The developed model is planned to be used in the future to determine the areas of risk of respiratory pathologies caused by the negative impact of aerogenic environmental factors.
Journalist in the Terror Scenery: Camille Desmoulins and the Old Cordelier
Authors: Gotovtseva Anastasiya Gennad'evna
Published: October 2024

The article presents a detailed history of Camille Desmoulins' newspaper "The Old Cordelier" in the historical and political context of the Jacobin terror. The content of seven issues of the newspaper is examined, and an attempt is made to reveal Desmoulins' concept of the publication in his dispute with the leader of the extreme left, Hébert, and the all-powerful dictator Robespierre. The first issues of "The Old Cordelier" satisfied Robespierre because they aimed at Hébert and the cult of Reason preached by him. However, gradually the meaning of Desmoulins' texts began to change. The journalist began to write about the shortcomings of the entire machine of state terror and, eventually, inevitably, to criticize Robespierre. Already with his third issue, Desmoulins aroused the discontent of the Jacobin and Cordelier Clubs, from which he was expelled shortly after. The sixth issue was held up by the publisher Desenne, who demanded that the most acute fragments be removed. The seventh issue of the newspaper, which Desmoulins was editing when he was arrested, was published only after Thermidor, and even then with cuts. Desmoulins' political views, which were quite radical at the beginning of the Revolution, underwent a significant evolution against the backdrop of the Terror. In order to influence events, he returned to journalism and began publishing his own newspaper again - an activity he had abandoned when he moved away from publishing the periodical brochure "Revolutions of France and Brabant". A talented journalist, Desmoulins constructed the texts of his issues using "Aesopian" language and allegorical images, which, however, were quite understandable to his contemporaries. Desmoulins' political position became increasingly irreconcilable with the government's terrorist policy. In the end, the fight against Robespierre from the pages of the newspapers led to Desmoulins ending up on the guillotine.
A neurotrophin functioning with a Toll regulates structural plasticity in a dopaminergic circuit
Authors: Sun Jun , Rojo-Cortes Francisca , Ulian-Benitez Suzana , Forero Manuel G , Li Guiyi , Singh Deepanshu ND , Wang Xiaocui , Cachero Sebastian , Moreira Marta , Kavanagh Dean , Jefferis Gregory SXE , Croset Vincent , Hidalgo Alicia
Published: October 2024

Experience shapes the brain as neural circuits can be modified by neural stimulation or the lack of it. The molecular mechanisms underlying structural circuit plasticity and how plasticity modifies behaviour are poorly understood. Subjective experience requires dopamine, a neuromodulator that assigns a value to stimuli, and it also controls behaviour, including locomotion, learning, and memory. In Drosophila, Toll receptors are ideally placed to translate experience into structural brain change. Toll-6 is expressed in dopaminergic neurons (DANs), raising the intriguing possibility that Toll-6 could regulate structural plasticity in dopaminergic circuits. Drosophila neurotrophin-2 (DNT-2) is the ligand for Toll-6 and Kek-6, but whether it is required for circuit structural plasticity was unknown. Here, we show that DNT-2-expressing neurons connect with DANs, and they modulate each other. Loss of function for DNT-2 or its receptors Toll-6 and kinase-less Trk-like kek-6 caused DAN and synapse loss, impaired dendrite growth and connectivity, decreased synaptic sites, and caused locomotion deficits. In contrast, over-expressed DNT-2 increased DAN cell number, dendrite complexity, and promoted synaptogenesis. Neuronal activity modified DNT-2, increased synaptogenesis in DNT-2-positive neurons and DANs, and over-expression of DNT-2 did too. Altering the levels of DNT-2 or Toll-6 also modified dopamine-dependent behaviours, including locomotion and long-term memory. To conclude, a feedback loop involving dopamine and DNT-2 highlighted the circuits engaged, and DNT-2 with Toll-6 and Kek-6 induced structural plasticity in this circuit modifying brain function and behaviour.
Extramacrochaetae regulates Notch signaling in the Drosophila eye through non-apoptotic caspase activity
Authors: Nair Sudershana , Baker Nicholas E
Published: October 2024

Many cell fate decisions are determined transcriptionally. Accordingly, some fate specification is prevented by Inhibitor of DNA binding (Id) proteins that interfere with DNA binding by master regulatory transcription factors. We show that the
Drosophila
Id protein Extra macrochaetae (Emc) also affect developmental decisions by regulating caspase activity. Emc, which prevents proneural bHLH transcription factors from specifying neural cell fate, also prevents homodimerization of another bHLH protein, Daughterless (Da), and thereby maintains expression of the
Death-Associated Inhibitor of Apoptosis
(
diap1
) gene. We found that multiple effects of
emc
mutations on cell growth and on eye development were all caused by reduced
Diap1
levels and corresponding activation of caspases. These effects included acceleration of the morphogenetic furrow, failure of R7 photoreceptor cell specification, and delayed differentiation of non-neuronal cone cells. Within
emc
mutant clones, Notch signaling was elevated in the morphogenetic furrow, increasing morphogenetic furrow speed. This was associated with caspase-dependent increase in levels of Delta protein, the transmembrane ligand for Notch. Posterior to the morphogenetic furrow, elevated Delta cis-inhibited Notch signaling that was required for R7 specification and cone cell differentiation. Thus,
emc
mutations reveal the importance of restraining caspase activity even in non-apoptotic cells to prevent abnormal development, in the
Drosophila
eye through effects on Notch signaling.
Receptor tyrosine kinases CAD96CA and FGFR1 function as the cell membrane receptors of insect juvenile hormone
Authors: Li Yan-Xue , Kang Xin-Le , Li Yan-Li , Wang Xiao-Pei , Yan Qiao , Wang Jin-Xing , Zhao Xiao-Fan
Published: October 2024

Juvenile hormone (JH) is important to maintain insect larval status; however, its cell membrane receptor has not been identified. Using the lepidopteran insect
Helicoverpa armigera
(cotton bollworm), a serious agricultural pest, as a model, we determined that receptor tyrosine kinases (RTKs) cadherin 96ca (CAD96CA) and fibroblast growth factor receptor homologue (FGFR1) function as JH cell membrane receptors by their roles in JH-regulated gene expression, larval status maintaining, rapid intracellular calcium increase, phosphorylation of JH intracellular receptor MET1 and cofactor Taiman, and high affinity to JH III. Gene knockout of
Cad96ca
and
Fgfr1
by CRISPR/Cas9 in embryo and knockdown in various insect cells, and overexpression of CAD96CA and FGFR1 in mammalian HEK-293T cells all supported CAD96CA and FGFR1 transmitting JH signal as JH cell membrane receptors.
Derivation and Internal Validation of Prediction Models for Pulmonary Hypertension Risk Assessment in a Cohort Inhabiting Tibet, China
Authors: Tang Junhui , Yang Rui , Li Hui , Wei Xiaodong , Yang Zhen , Cai Wenbin , Jiang Yao , Zhuo Ga , Meng Li , Xu Yali
Published: October 2024

Due to exposure to hypoxic environments, individuals residing in plateau regions are susceptible to pulmonary hypertension (PH). Consequently, there is an urgent need for a simple and efficient nomogram to assess the risk of PH in this population.This study included a total of 6,603 subjects, who were randomly divided into a validation set and a derivation set at a ratio of 7:3. Optimal predictive features were identified through the least absolute shrinkage and selection operator regression technique, and nomograms were constructed using multivariate logistic regression. The performance of these nomograms was evaluated and validated using the area under the curve (AUC), calibration curves, the Hosmer-Lemeshow test, and decision curve analysis. Comparisons between nomograms were conducted using the net reclassification improvement (NRI) and integrated discrimination improvement (IDI) indices.Nomogram
I
was established based on independent risk factors, including gender, Tibetan ethnicity, age, incomplete right bundle branch block (IRBBB), atrial fibrillation (AF), sinus tachycardia (ST), and T wave changes (TC). The AUCs for Nomogram
I
were 0.716 in the derivation set and 0.718 in the validation set. Nomogram
II
was established based on independent risk factors, including Tibetan ethnicity, age, right axis deviation (RAD), high voltage in the right ventricle (HVRV), IRBBB, AF, pulmonary P waves, ST, and TC. The AUCs for Nomogram
II
were 0.844 in the derivation set and 0.801 in the validation set. Both nomograms demonstrated satisfactory clinical consistency. The IDI and NRI indices confirmed that Nomogram
II
outperformed Nomogram
I
. Therefore, the online dynamic Nomogram
II
was established.A reliable and straightforward nomogram was developed to predict the risks of PH in the plateau population.
Systematic genetic characterization of the human PKR kinase domain highlights its functional malleability to escape a poxvirus substrate mimic
Authors: Chambers Michael J , Scobell Sophia B , Sadhu Meru J
Published: October 2024

Evolutionary arms races can arise at the contact surfaces between host and viral proteins, producing dynamic spaces in which genetic variants are continually pursued. However, the sampling of genetic variation must be balanced with the need to maintain protein function. A striking case is given by protein kinase R (PKR), a member of the mammalian innate immune system. PKR detects viral replication within the host cell and halts protein synthesis to prevent viral replication by phosphorylating eIF2α, a component of the translation initiation machinery. PKR is targeted by many viral antagonists, including poxvirus pseudosubstrate antagonists that mimic the natural substrate, eIF2α, and inhibit PKR activity. Remarkably, PKR has several rapidly evolving residues at this interface, suggesting it is engaging in an evolutionary arms race, despite the surface’s critical role in phosphorylating eIF2α. To systematically explore the evolutionary opportunities available at this dynamic interface, we generated and characterized a library of 426 SNP-accessible nonsynonymous variants of human PKR for their ability to escape inhibition by the model pseudosubstrate inhibitor K3, encoded by the vaccinia virus gene
K3L
. We identified key sites in the PKR kinase domain that harbor K3-resistant variants, as well as critical sites where variation leads to loss of function. We find K3-resistant variants are readily available throughout the interface and are enriched at sites under positive selection. Moreover, variants beneficial against K3 were also beneficial against an enhanced variant of K3, indicating resilience to viral adaptation. Overall, we find that the eIF2α-binding surface of PKR is highly malleable, potentiating its evolutionary ability to combat viral inhibition.
Acute responses and recovery in the femoral cartilage morphology following running and cool-down protocols
Authors: Park Sanghyup , Lim Junhyeong , Lee Jinwoo , Jeon Seonggyu , Kim Jaewon , Park Jihong
Published: October 2024

This study compared the immediate effects of two common post-exercise cool-down methods to a control condition on subsequent morphologic change in femoral cartilage and vascular response in the posterior tibial artery after running. Sixteen healthy young males (23.6 ± 2.2 years, 172.8 ± 4.9 cm, 72.2 ± 7.1 kg) visited the laboratory during three separate sessions and performed 30-min of treadmill running (7.5 km/h for the initial 5-min, followed 8.5 km/h for 25-min). After running, participants experienced one of three 30-min cool-down protocols: active cool-down, cold application, or control (seated rest with their knee fully extended), in a counterbalanced order. Ultrasonographic assessments of femoral cartilage thickness (intercondylar, lateral, and medial) and posterior tibial artery blood flow were compared. To test condition effects over time, two-way analysis of variances and Tukey tests were used (p < 0.05) with Cohen’s d effect sizes (ES). There was no condition by time interaction in femoral cartilage thickness (intercondylar: F30,705 = 0.91, p = 0.61; lateral: F30,705 = 1.24, p = 0.18; medial: F30,705 = 0.49, p = 0.99). Regardless of time (condition effect: F2,705 > 3.24, p < 0.04 for all tests), femoral cartilage in the cold application condition was thicker than the control condition (intercondylar: p = 0.01, ES = 0.16; lateral: p < 0.0001, ES = 0.24; medial: p = 0.04. ES = 0.16). Regardless of condition (time effect: F15,705 > 10.31, p < 0.0001 for all tests), femoral cartilage thickness was decreased after running (intercondylar: p < 0.0001, ES = 1.37; lateral: p < 0.0001, ES = 1.58; medial: p < 0.0001, ES = 0.81) and returned to baseline levels within 40-min (intercondylar: p = 0.09; lateral: p = 0.64; medial: p = 0.26). Blood flow volume was different (condition × time: F30,705 = 2.36, p < 0.0001) that running-induced blood flow volume was maintained for 30-min for the active cool-down condition (p < 0.0001, ES = 1.64), whereas it returned to baseline levels within 10-min for other conditions (cold application: p = 0.67; control: p = 0.62). Neither blood flow nor temperature had a significant impact on the recovery in femoral cartilage after running.
Silver nanoparticles can be sampled by ultrafiltration probe but elution into & recovery from plasma and Dulbecco’s Phosphate Buffered Saline differs in vitro
Authors: Risselada Marije , McCain Robyn R. , Bates Miriam G. , Anderson Makensie L.
Published: October 2024

Locally sustained release antimicrobials such as silver nanoparticles (AgNPs) might prove useful in combating local infections. Their elution has been investigated in Phosphate Buffered Saline (PBS) including from poloxamer 407 (P407). No information exists on possible interactions with proteins, nor have ultrafiltration (UF) probes been evaluated to measure Ag. These investigations would provide helpful data prior to investigating the sustained release after subcutaneous implantation in vivo over time. We compared (1) the influence of elution fluid on AgNP elution, and (2) UF probe and direct sampling in vitro. Six AgNP-P407 specimens in a dialysis tube were placed in Dulbecco’s PPBS (DPBS) (n = 3) or canine plasma (n = 3) for 96 h on a stirred hot plate (37 °C and 600 rpm) and sampled 20 times. A 0.001 mg/mL AgNP solution was prepared in DPBS or plasma. Six pipette and UF probe samples were taken of each. Inductively coupled plasma mass spectrometry was used to analyze Ag. Stock plasma contained Ag. At 96 h, 5/6 dialysis tubes had not fully released AgNP. One peak in hourly Ag increase was present in DPBS (10–13 h), and two peaks in plasma (6–8 and 10–13 h). The hourly Ag increase in plasma decreased earlier than in DPBS. Ultrafiltration probe sampling was possible in both DPBS and plasma and resulted in higher Ag concentrations but with more variation. While in vitro use of DPBS might be more cost effective, plasma should be considered due to difference in elution and recovery. Ultrafiltration probes can be used to sample Ag, but results will have a greater degree of variation, and multiple samples and increased time points should be considered.
WATER LEGISLATION IN INDIA AS PRIORITY ASPECT OF WATER RESOURCES MANAGEMENT
Authors: Irfan Ali
Published: October 2024

Effective water resource management is contingent on sound water legislation, which plays a crucial role in shaping worldwide water management strategies. The objective of this review is to analyze water policies and legislation in India, and pinpoint issues in water policy implementation and management. Additionally, the review includes an examination of the European Water Framework Directive (WFD) to explore the differences between European water legislation assumptions and water management, which can aid in adapting certain EU assumptions to Indian legislation. India faces urgent water-related problems due to inadequate water resource management in individual states and nationwide, which can be mitigated by implementing coherence in water policies and collaborating with policymakers, practitioners, and stakeholders from various economic sectors to enhance water governance strategies. Comparative analysis revealed that the European Water Framework Directive adopts a more specific and integrated approach, supported by precise legal regulation, wide-ranging stakeholder involvement, and investments in technology and infrastructure to achieve its set water management goals. In contrast, the Indian water legislation framework lacks a systemic approach, and the main gap lies in the inconsistency between national and state water legislation and the lack of proper coordination between the state and central governments. Unifying legal regulations at the national and state levels in cooperation with responsible legislative and executive institutions at appropriate governmental levels can help solve water management problems and achieve set goals.
Quality Management And Its Applicability As A Management Tool For Customer Satisfaction In The Service Sector
Authors: Lima Lucas Alves De Oliveira , Junior Paulo Lourenço Domingues , Silva Robson Tavares Da
Published: October 2024

The aim of this research was to analyse quality management in the service sector in order to clarify how quality management can be implemented to guarantee customer satisfaction and excellence in service provision, taking into account the peculiar characteristics of services compared to tangible products. To this end, bibliographical research was carried out by searching for articles in databases such as SciELO, Scopus, Web of Science and Google Scholar, as well as institutional repositories. During the search, specific keywords were used in association with Boolean operators AND and OR. The analysis of quality management in the service sector showed that the application of specific practices is crucial to meeting the challenges inherent in this sector, with the aim of guaranteeing customer satisfaction and operational excellence. The research addressed the intangibility of services, emphasising the need to create tangible evidence of quality through communication and visual materials, to help customers evaluate the service before purchase. Variability was also discussed, highlighting the importance of standardising processes and implementing technology and continuous training to reduce differences in the quality of the service provided. The perishability of services, with their dynamic nature and impossibility of storage, was addressed with a focus on adaptive strategies, such as capacity management and the use of technologies to adjust demand, including reservation systems and price flexibility. Inseparability, meanwhile, highlighted the importance of interaction between provider and customer, highlighting the need for effective staff training and the adoption of technologies for personalisation and queue management. Therefore, adopting an integrated approach, which takes into account the unique characteristics of services and adopts adapted practices, is essential for improving perceived quality, strengthening companies' competitiveness and ensuring their long-term sustainability.
Plano De Negócios E As Contribuições Para Micro E Pequenos Empreendedores
Authors: Silva Amanda Firmina Da , Alcantara Beatriz Tereza Dos Reis Anselmo , Garcia Rafaela Dos Santos , Roque Camila Martins
Published: October 2024

Esta pesquisa teve como objetivo analisar as contribuições do Plano de Negócios para micro e pequenos empreendedores, destacando sua importância na estruturação e sucesso desses negócios. A metodologia utilizada foi a pesquisa bibliográfica, com levantamentos em plataformas reconhecidas como SciELO, Scopus e Google Acadêmico, além de repositórios brasileiros, o que garantiu uma base teórica sólida. Os resultados indicaram que o Plano de Negócios proporciona uma visão clara das estratégias a serem adotadas, facilita a análise de mercado e define objetivos financeiros, além de ser uma ferramenta crucial para a comunicação com investidores. A análise revelou que, ao permitir a adaptação às mudanças do mercado, o plano se torna um guia contínuo para o empreendedor. A conclusão enfatiza que, além de ser um documento organizacional, o Plano de Negócios é fundamental para aumentar as chances de sucesso dos micro e pequenos empreendedores, promovendo a inovação e contribuindo para o desenvolvimento econômico.
Cidades Sustentáveis: As Contribuições De Tecnologias Para A Sustentabilidade E O Meio Ambiente
Authors: Santos Rômulo Ferreira Dos , Pupio Elizamar Gomes Da Silva , Santos Adelcio Machado Dos , Silva Givanildo Rodrigues Da , Meller Guilherme Semprebom
Published: October 2024

O objetivo desta pesquisa foi explorar como as tecnologias contribuem para o desenvolvimento de cidades inteligentes e sustentáveis, promovendo a eficiência urbana e a preservação ambiental. Utilizando uma metodologia de pesquisa bibliográfica, foram revisados diversos materiais acadêmicos e publicações especializadas em plataformas como Scielo, Scopus e Google Acadêmico, além de repositórios brasileiros. As leituras flutuantes e a análise crítica dos documentos permitiram identificar as principais inovações tecnológicas e práticas sustentáveis aplicadas nas cidades. Os resultados indicam que tecnologias como a Internet das Coisas (IoT), inteligência artificial (IA) e big data são fundamentais para otimizar a gestão de recursos urbanos, melhorar a eficiência do transporte e promover a construção de edifícios ecológicos. Essas tecnologias facilitam o monitoramento ambiental e a participação cidadã, oferecendo um modelo integrado para enfrentar desafios urbanos e ambientais. A análise conclui que, embora as tecnologias ofereçam soluções significativas, é crucial superar barreiras econômicas e garantir a segurança dos dados para maximizar os benefícios das cidades inteligentes e sustentáveis. O futuro das cidades dependerá da contínua inovação tecnológica e da colaboração entre setores para criar ambientes urbanos que equilibrem desenvolvimento e sustentabilidade
The PICS Technique: A Novel Approach for Residual Curvature Correction During Penile Prosthesis Implantation in Patients With Severe Peyronie's Disease Using the Collagen Fleece TachoSil
Authors: Hatzichristodoulou Georgios
Published: January 2018

Background

Correction of residual curvature during inflatable penile prosthesis (IPP) implantation in patients with Peyronie's disease (PD) by plaque incision and grafting is a common approach.

Aim

To present a novel technique for residual curvature correction during IPP implantation using collagen fleece (TachoSil, Baxter Healthcare Corp, Deerfield, IL, USA).

Methods

After the IPP (Titan Touch, Coloplast, Minneapolis, MN, USA) is placed, the implant is inflated maximally. When residual curvature exceeds 40°, the PICS (penile implant in combination with the Sealing technique) technique is performed. The device is deflated, and a circumcising skin incision and penile degloving are performed. After elevation of the neurovascular bundle, the device is reinflated maximally. Plaque incision is performed at the point of maximum curvature using electrocautery. This leads to penile straightening because the tension is removed. In the next step, the defect of the tunica is closed with collagen fleece, which sticks to the tunica and defect without any sutures needed. The neurovascular bundle is reapproximated and the Buck fascia is closed. This is followed by closure of penile skin.

Outcomes

Primary outcome measurements were straightening rates, operative times, 5-item International Index of Erectile Function (IIEF-5) scores at follow-up, immediate and late complications, and patient satisfaction.

Results

The PICS technique was applied to 15 patients. Mean patient age was 61.7 years (52–79 years). Mean residual curvature after IPP was 66.7° (50–90°). Mean operative time was 117.3 minutes (100–140 minutes). Mean follow-up was 15.1 months (1–29 months). 12 of 15 patients (80%) showed a totally straight penis. 3 patients (20%) had residual curvature of 10° at follow-up, which did not interfere with sexual intercourse. Mean IIEF-5 score at follow-up was 24.2 (22–25). No immediate or late complications occurred. All patients were satisfied with the surgical outcomes.

Clinical Implications

This novel technique prevents puncture or injury of the device, because the collagen fleece does not require suture fixation into the defect after plaque incision.

Strengths and Limitations

This technique can be applied to patients with severe PD who display residual curvature greater than 40° after IPP placement. It is a fast approach with low complication rates. Limitations include the small patient population and short follow-up.

Conclusion

The PICS technique represents a safe and time-saving approach for residual curvature correction during IPP placement in patients with PD and prevents device puncture.