bluuebunny/crossref_metadata_2025 huggingface dataset:
Microbial impact on initial soil formation in arid and semiarid environments under simulated climate change
Authors: Rodríguez Victoria , Bartholomäus Alexander , Witzgall Kristina , Riveras-Muñoz Nicolás , Oses Romulo , Liebner Susanne , Kallmeyer Jens , Rach Oliver , Mueller Carsten W. , Seguel Oscar , Scholten Thomas , Wagner Dirk
Published: January 2024

The microbiota is attributed to be important for initial soil formation under extreme climate conditions, but experimental evidence for its relevance is scarce. To fill this gap, we investigated the impact of in situ microbial communities and their interrelationship with biocrust and plants compared to abiotic controls on soil formation in initial arid and semiarid soils. Additionally, we assessed the response of bacterial communities to climate change. Topsoil and subsoil samples from arid and semiarid sites in the Chilean Coastal Cordillera were incubated for 16 weeks under diurnal temperature and moisture variations to simulate humid climate conditions as part of a climate change scenario. Our findings indicate that microorganism-plant interaction intensified aggregate formation and stabilized soil structure, facilitating initial soil formation. Interestingly, microorganisms alone or in conjunction with biocrust showed no discernible patterns compared to abiotic controls, potentially due to water-masking effects. Arid soils displayed reduced bacterial diversity and developed a new community structure dominated by Proteobacteria, Actinobacteriota, and Planctomycetota, while semiarid soils maintained a consistently dominant community of Acidobacteriota and Proteobacteria. This highlighted a sensitive and specialized bacterial community in arid soils, while semiarid soils exhibited a more complex and stable community. We conclude that microorganism-plant interaction has measurable impacts on initial soil formation in arid and semiarid regions on short time scales under climate change. Additionally, we propose that soil and climate legacies are decisive for the present soil microbial community structure and interactions, future soil development, and microbial responses.
Research progress in brain-targeted nasal drug delivery
Authors: Huang Qingqing , Chen Xin , Yu Sixun , Gong Gu , Shu Haifeng
Published: January 2024

The unique anatomical and physiological connections between the nasal cavity and brain provide a pathway for bypassing the blood–brain barrier to allow for direct brain-targeted drug delivery through nasal administration. There are several advantages of nasal administration compared with other routes; for example, the first-pass effect that leads to the metabolism of orally administered drugs can be bypassed, and the poor compliance associated with injections can be minimized. Nasal administration can also help maximize brain-targeted drug delivery, allowing for high pharmacological activity at lower drug dosages, thereby minimizing the likelihood of adverse effects and providing a highly promising drug delivery pathway for the treatment of central nervous system diseases. The aim of this review article was to briefly describe the physiological structures of the nasal cavity and brain, the pathways through which drugs can enter the brain through the nose, the factors affecting brain-targeted nasal drug delivery, methods to improve brain-targeted nasal drug delivery systems through the application of related biomaterials, common experimental methods used in intranasal drug delivery research, and the current limitations of such approaches, providing a solid foundation for further in-depth research on intranasal brain-targeted drug delivery systems (see Graphical Abstract).
Insulin-like growth factor 2 (IGF-2) rescues social deficits in NLG3–/y mouse model of ASDs
Authors: Pizzarelli Rocco , Pimpinella Domenico , Jacobs Christian , Tartacca Alice , Kullolli Uarda , Monyer Hannah , Alberini Cristina M. , Griguoli Marilena
Published: January 2024

Autism spectrum disorders (ASDs) comprise developmental disabilities characterized by impairments of social interaction and repetitive behavior, often associated with cognitive deficits. There is no current treatment that can ameliorate most of the ASDs symptomatology; thus, identifying novel therapies is urgently needed. Here, we used the Neuroligin 3 knockout mouse (NLG3–/y), a model that recapitulates the social deficits reported in ASDs patients, to test the effects of systemic administration of IGF-2, a polypeptide that crosses the blood-brain barrier and acts as a cognitive enhancer. We show that systemic IGF-2 treatment reverses the typical defects in social interaction and social novelty discrimination reflective of ASDs-like phenotypes. This effect was not accompanied by any change in spontaneous glutamatergic synaptic transmission in CA2 hippocampal region, a mechanism found to be crucial for social novelty discrimination. However, in both NLG3+/y and NLG3–/y mice IGF-2 increased cell excitability. Although further investigation is needed to clarify the cellular and molecular mechanisms underpinning IGF-2 effect on social behavior, our findings highlight IGF-2 as a potential pharmacological tool for the treatment of social dysfunctions associated with ASDs.
Identifying distinctive brain regions related to consumer choice behaviors on branded foods using activation likelihood estimation and machine learning
Authors: Watanuki Shinya
Published: January 2024

Introduction

Brand equity plays a crucial role in a brand’s commercial success; however, research on the brain regions associated with brand equity has had mixed results. This study aimed to investigate key brain regions associated with the decision-making of branded and unbranded foods using quantitative neuroimaging meta-analysis and machine learning.

Methods

Quantitative neuroimaging meta-analysis was performed using the activation likelihood method. Activation of the ventral medial prefrontal cortex (VMPFC) overlapped between branded and unbranded foods. The lingual and parahippocampal gyri (PHG) were activated in the case of branded foods, whereas no brain regions were characteristically activated in response to unbranded foods. We proposed a novel predictive method based on the reported foci data, referencing the multi-voxel pattern analysis (MVPA) results. This approach is referred to as the multi-coordinate pattern analysis (MCPA). We conducted the MCPA, adopting the sparse partial least squares discriminant analysis (sPLS-DA) to detect unique brain regions associated with branded and unbranded foods based on coordinate data. The sPLS-DA is an extended PLS method that enables the processing of categorical data as outcome variables.

Results

We found that the lingual gyrus is a distinct brain region in branded foods. Thus, the VMPFC might be a core brain region in food categories in consumer behavior, regardless of whether they are branded foods. Moreover, the connection between the PHG and lingual gyrus might be a unique neural mechanism in branded foods.

Discussion

As this mechanism engages in imaging the feature-self based on emotionally subjective contextual associative memories, brand managers should create future-oriented relevancies between brands and consumers to build valuable brands.
Treatment effects of N-acetyl cysteine on resting-state functional MRI and cognitive performance in patients with chronic mild traumatic brain injury: a longitudinal study
Authors: Vedaei Faezeh , Newberg Andrew B. , Alizadeh Mahdi , Zabrecky George , Navarreto Emily , Hriso Chloe , Wintering Nancy , Mohamed Feroze B. , Monti Daniel
Published: January 2024

Mild traumatic brain injury (mTBI) is a significant public health concern, specially characterized by a complex pattern of abnormal neural activity and functional connectivity. It is often associated with a broad spectrum of short-term and long-term cognitive and behavioral symptoms including memory dysfunction, headache, and balance difficulties. Furthermore, there is evidence that oxidative stress significantly contributes to these symptoms and neurophysiological changes. The purpose of this study was to assess the effect of N-acetylcysteine (NAC) on brain function and chronic symptoms in mTBI patients. Fifty patients diagnosed with chronic mTBI participated in this study. They were categorized into two groups including controls (CN, n = 25), and patients receiving treatment with N-acetyl cysteine (NAC, n = 25). NAC group received 50 mg/kg intravenous (IV) medication once a day per week. In the rest of the week, they took one 500 mg NAC tablet twice per day. Each patient underwent rs-fMRI scanning at two timepoints including the baseline and 3 months later at follow-up, while the NAC group received a combination of oral and IV NAC over that time. Three rs-fMRI metrics were measured including fractional amplitude of low frequency fluctuations (fALFF), degree centrality (DC), and functional connectivity strength (FCS). Neuropsychological tests were also assessed at the same day of scanning for each patient. The alteration of rs-fMRI metrics and cognitive scores were measured over 3 months treatment with NAC. Then, the correlation analysis was executed to estimate the association of rs-fMRI measurements and cognitive performance over 3 months (p < 0.05). Two significant group-by-time effects demonstrated the changes of rs-fMRI metrics particularly in the regions located in the default mode network (DMN), sensorimotor network, and emotional circuits that were significantly correlated with cognitive function recovery over 3 months treatment with NAC (p < 0.05). NAC appears to modulate neural activity and functional connectivity in specific brain networks, and these changes could account for clinical improvement. This study confirmed the short-term therapeutic efficacy of NAC in chronic mTBI patients that may contribute to understanding of neurophysiological effects of NAC in mTBI. These findings encourage further research on long-term neurobehavioral assessment of NAC assisting development of therapeutic plans in mTBI.
Performance of biomarkers NF-L, NSE, Tau and GFAP in blood and cerebrospinal fluid in rat for the detection of nervous system injury
Authors: Vlasakova Katerina , Tsuchiya Takayuki , Garfinkel Ivy N. , Ruth Michael P. , Tyszkiewicz Cheryl , Detwiler Theodore J. , Somps Christopher J. , Di Cesare Mannelli Lorenzo , Glaab Warren E.
Published: January 2024

Background

Target organ toxicity is often a reason for attritions in nonclinical and clinical drug development. Leveraging emerging safety biomarkers in nonclinical studies provides an opportunity to monitor such toxicities early and efficiently, potentially translating to early clinical trials. As a part of the European Union’s Innovative Medicines Initiative (IMI), two projects have focused on evaluating safety biomarkers of nervous system (NS) toxicity: Translational Safety Biomarker Pipeline (TransBioLine) and Neurotoxicity De-Risking in Preclinical Drug Discovery (NeuroDeRisk).

Methods

Performance of fluid-based NS injury biomarker candidates neurofilament light chain (NF-L), glial fibrillary acidic protein (GFAP), neuron specific enolase (NSE) and total Tau in plasma and cerebrospinal fluid (CSF) was evaluated in 15 rat in vivo studies. Model nervous system toxicants as well as other compounds were used to evaluate sensitivity and specificity. Histopathologic assessments of nervous tissues and behavioral observations were conducted to detect and characterize NS injuries. Receiver operator characteristic (ROC) curves were generated to compare the relative performance of the biomarkers in their ability to detect NS injury.

Results

NF-L was the best performer in detecting both peripheral nervous system (PNS) and CNS injury in plasma, (AUC of 0.97–0.99; respectively). In CSF, Tau correlated the best with CNS (AUC 0.97), but not PNS injury. NSE and GFAP were suitable for monitoring CNS injury, but with lesser sensitivity. In summary, NF-L is a sensitive and specific biomarker in rats for detecting compound-induced central and peripheral NS injuries. While NF-L measurement alone cannot inform the site of the injury, addition of biomarkers like Tau and NSE and analysis in both blood and CSF can provide additional information about the origin of the NS injury.

Conclusion

These results demonstrate the utility of emerging safety biomarkers of drug-induced NS injury in rats and provide additional supporting evidence for biomarker translation across species and potential use in clinical settings to monitor drug-induced NS injury in patients.
Nutrition knowledge, weight loss practices, and supplement use in senior competition climbers
Authors: Gibson-Smith Edward , Storey Ryan , Michael Marisa , Ranchordas Mayur
Published: January 2024

Introduction

Sport climbing has gained increased scientific attention, including studies investigating the dietary habits and nutritional requirements of climbers; however, significant gaps in the literature remain. An assessment of nutritional knowledge, weight loss for competition, and supplement use has not been previously reported in senior competition climbing athletes.

Methods

Fifty climbers (26 male, 24 female; BMI 21.6 ± 1.9; 23.7 ± 5.2 years) participated in the study. Participants answered a 72-item questionnaire, comprised of demographic data and three main sections to assess general and sports nutrition knowledge, weight loss strategies, and supplement use.

Results

The mean nutrition knowledge score was ‘average’, with considerable individual variation (53.5 ± 11.1 %). There were no significant sex differences in the general (GNK) or sport (SNK) nutrition knowledge scores, or effect of age. Significantly higher knowledge was demonstrated by national vs. international athletes for the GNK scores (11.09 ± 1.58 vs. 9.58 ± 1.75; p = 0.028). Participants scored well in questions concerning protein, carbohydrates, alcohol, and supplements, and conversely, performed poorly in hydration and micronutrient related questions. Less than one-fifth of respondents had access to a dietitian. Forty-six percent of males and 38% of female climbers reported intentional weight loss for competition on at least one occasion. Of those, ~76% reported utilizing concerning practices, including methods that conform with disordered eating and/or eating disorders, dehydration, vomiting, and misuse of laxatives. Approximately 65% of athletes reported using at least one nutritional supplement in the previous 6 months, with 44% reporting multiple supplement use. There was no significant difference in supplement use between sexes or competition level.

Discussion

Due to the established importance of nutritional intake on athlete health and performance, educational support should be employed to improve knowledge in climbers and address shortcomings. Moreover, intentional weight loss for climbing competition is common, with most athletes achieving ~3–8% body weight loss over ≥2 weeks. It is crucial that professionals working with competitive climbers are vigilant in identifying athletes at risk of concerning weight management and establish referral pathways to the appropriate specialist services. High quality intervention trials to assess the efficacy of ergogenic aids in climbing remains inadequate.
The effects of intermittent fasting for patients with multiple sclerosis (MS): a systematic review
Authors: Lin Xiaoxiao , Wang Shuai , Gao Yue
Published: January 2024

Some studies have investigated the impact of intermittent fasting (IF) for patients with multiple sclerosis (MS). We aimed to conduct a comprehensive systematic review to analyze and summarize all clinical studies concerning the effects of IF on patients with MS. We conducted an exhaustive review of information available in the Embase, Cochrane, and PubMed databases up until 1 September 2023. All clinical research relating to the impacts of IF for patients with MS were included. In total, this systematic review encompassed 5 studies, which included four RCTs and one pilot study. Each study involved was assessed of high quality. The results from these studies demonstrate that IF protocols could potentially serve as an effective dietary strategy for managing symptoms and improving the quality of life in individuals afflicted with MS. In conclusion, IF might be a potential beneficial dietary intervention for MS. However, the number of trials in this field is relatively limited. The large-scale clinical trials to investigate the effects of IF for MS are urgently needed, which may be helpful to manage this intricate neuroimmune disorder.

Systematic review registration

https://inplasy.com, identifier INPLASY2023100021.
Using coupons to encourage healthier child snack purchases in corner stores: results from the CHOMPS study
Authors: Mayer Megan E. , McAlister Anna R. , Economos Christina D. , Mack Suzanne , Plank Kaela , Cash Sean B.
Published: January 2024

Objectives

To examine youths’ (ages 6–15 years) autonomous snack purchases in corner stores and pilot use of coupons to encourage more healthful snack purchases.

Methods

This pilot study involved four corner stores proximal to K-8 schools in Massachusetts. Kids-only coupons of varying discounts were provided in store and paired with simple visual and verbal economic and health messages. Observational data about youths’ autonomous snack purchases was recorded pre- and post-intervention. Outcomes of interest were snack item, price, and nutrient content. Comparisons of purchase characteristics and nutritional content across intervention conditions were made using Chi-squared and t-tests.

Results

Across all stores, 2,973 purchase observations were recorded totaling approximately $6,000. Researchers estimated that about 55% of shoppers were 10–12 years old. Modest coupon usage (2.2% of purchases) was noted. However, candy purchases decreased, and the percentage of purchase events that included at least one healthier food item more than doubled, regardless of coupon use. Improvements in the nutritional content of snacks were also observed.

Conclusion

Kids-only coupons have the potential to assist with shifting autonomous snack purchase behavior in outside of school settings.
Clinical application of spectral CT perfusion scanning in evaluating the blood supply source of portal vein tumor thrombus in hepatocellular carcinoma
Authors: Pan Chunhan , Dai Feng , Sheng Liuli , Li Kang , Qiao Wei , Kang Zheng , Zhang Xiuming
Published: January 2024

Purpose

To evaluate the characteristic of blood supply of liver portal vein tumor thrombus (PVTT) using perfusion indexes and spectral parameters.

Methods

Between July 2020 and December 2022, the study enrolled 25 liver cancer patients completed with PVTT (male=20, female=5; age 41-74 years (59.48 ± 9.12)) from the Interventional Department of Jiangsu Cancer Hospital. There were 11 cases of type III PVTT, 12 of type II PVTT, and 2 of type I PVTT (Cheng’s classification). All patients underwent spectral perfusion scans through dual-layer spectral detector computed tomography. The PVTTs were divided into proximal and distal groups based on the distance between the tumor thrombus and the main portal vein. The perfusion analysis was performed on the 120-kVp conventional images to generate hepatic perfusion index (HPI). The spectral based images (SBIs) during the artery and venous peak phases were extracted from the perfusion data. The iodine map and 40&100-keV virtual monoenergetic image (VMI) were generated from SBI data. HPI, iodine concentration (IC), CT value at 40 and 100-keV, and spectral slope (40-100keV) of the primary lesion, proximal and distal PVTT, and liver parenchyma were measured and compared. The correlation between the primary lesion and proximal and distal PVTT was analyzed.

Results

The IC and spectral slope during the arterial and venous peak phases and HPI of the primary lesion, proximal PVTT, and distal PVTT were highly correlated (P<0.001). The differences between the IC and spectral slope during the arterial and venous peak phases and HPI of the primary lesion, proximal PVTT were statistically significant (P<0.001). The differences between the IC during venous peak phase and HPI of primary lesion, distal PVTT were statistically significant (P<0.001), and there was no statistically significant difference in arterial phase IC, arterial and venous phase spectral slopes.

Conclusion

The IC, slope, and HPI of the distal and proximal PVTT were highly correlated with the primary lesion, indicating that PVTT was similar to the primary lesion in the liver that they were both mainly supplied by the hepatic artery. However, there was still significant heterogeneity between the proximal PVTT and the primary lesion, while the difference in the distal PVTT was relatively small.
The impact of parental overprotection on the emotions and behaviors of pediatric hematologic cancer patients: a multicenter cross-sectional study
Authors: Yu Yahui , Zheng Xiaofeng , Xu Wenjing , Huang Yuru , Wang Xulu , Hong Wanting , Wang Runping , Ye Xiaojing , Zhang Chunmei
Published: January 2024

Background

Parental overprotection may have an impact on children’s emotional and behavioral problems (EBPs). As pediatric hematologic cancer patients have compromised immune systems, parents of such children often worry excessively, interfering with their daily lives. Therefore, avoiding overprotection is crucial for the overall physical and mental health of pediatric hematologic cancer patients.

Aims

The aim of this study was to examine the current status of EBPs in pediatric hematologic cancer patients and analyze their associated risk factors.

Design

This work was a multicenter cross-sectional observational and correlational study. We collected data anonymously through parental questionnaires from three pediatric hematologic oncology hospitals in China. The Strengths and Difficulties Questionnaire, the Parental Overprotection Measure (POM) scale, and a general information survey designed by the research team were employed to assess children’s EBPs, the degree of parental overprotection, as well as basic demographic and disease-related information. Chi-square tests and generalized linear mixed-effects regression analysis were used to analyze the factors influencing EBPs among the pediatric hematologic cancer patients.

Setting and participants

Using a convenience sampling method, a total of 202 participants’ parents were selected. All participants were invited to complete the questionnaire through one-on-one guidance.

Results

Emotional symptoms accounted for the highest proportion of abnormal EBPs in children (27.72%), followed by peer problems (26.24%), prosocial behavior (25.74%), behavioral problems (14.36%), and total difficulties (13.86%). A minority of children had abnormal hyperactivity scores (4.95%). The results of a generalized linear mixed regression analysis showed that age, duration of illness, and parental overprotection were significant factors influencing abnormal EBPs in children (p < 0.05). A POM score threshold of 37 exhibited good sensitivity (74%) and specificity (90%) in predicting abnormal EBPs in children.

Conclusion

Pediatric hematologic cancer patients under excessive parental protection are more prone to experiencing EBPs. Healthcare professionals should guide parents to reduce this excessive protection, thus mitigating the occurrence of EBPs in children.
Psychometric properties of the Chinese version of the health behavior motivation scale: a translation and validation study
Authors: Ge Yuanhui , Zheng Chen , Wang Xin , Liu Tao
Published: January 2024

Objective

This study’s objectives were to translate the Health Behavior Motivation Scale (HBMS) into Chinese and verify the scale’s validity and reliability among Chinese healthy adults.

Method

The HBMS scales were translated into Chinese based on Brislin’s principles. The Chinese version of HBMS is created through translation, back translation, and cross-cultural adaptation. This investigation implemented the convenience sampling method to conduct a survey on 781 healthy respondents, utilizing the Chinese version of the HBMS and a general demographic questionnaire. We used AMOS (v28.0) and SPSS (v26.0) for statistical analysis. We employed test–retest reliability, split-half reliability, and internal consistency to assess the reliability of the translation questionnaire. Structure validity and content validity were used to assess validity.

Results

The Chinese version of the Health Behavior Motivation Scale (HBMS) had a Cronbach’s alpha coefficient of 0.885, and the range of Cronbach’s alpha values for each dimension was 0.820–0.885. The scale’s test–retest reliability was 0.824, and its split-half reliability was 0.906. Five public factors with a cumulative variance contribution of 56.527% were retrieved from the exploratory factor analysis. Moreover, the factor loading value for each item exceeded 0.4.In confirmatory factor analysis, the indicators were reported as follows: χ2/df = 1.567, GFI = 0.900, CFI = 0.952, IFI = 0.952, TLI = 0.946, AGFI = 0.881, PGFI = 0.757, PNFI = 0.789, RMSEA = 0.039, and the results of the model fit metrics were within the reference range.

Conclusion

The Chinese version of the HBMS exhibits strong discrimination, validity, and reliability. The tool effectively identifies the motivation of healthy people to engage in healthy behaviors. It can be used by healthcare practitioners to assist in the development of follow-up interventions to reduce the prevalence of chronic disease in older people and the incidence of chronic disease in populations of young and middle-aged people.
Relationship between bedtime, nighttime sleep duration, and anxiety symptoms in preschoolers in China
Authors: Qiu Shuang-Yan , Yin Xiao-Na , Yang Yanni , Li Ting , Lu Dali , Li Jie-Min , Yang Wei-Kang , Wen Guo-Ming , Zhang Jing-Yu , Zhang Yan , Lei Hai-Yan , Wang Xin , Wu Jian-Bo
Published: January 2024

Background

Sleep problems in preschoolers are becoming increasingly prominent, and the association between sleep status and anxiety symptoms has attracted growing attention. However, studies investigating the relationship between bedtime and nighttime sleep duration in preschoolers and their anxiety symptoms remain scant. We used the large sample data from the Longhua Cohort Study of Children in Shenzhen, China (LCCS) to analyze the association between bedtime and sleep in preschoolers and their anxiety symptoms.

Methods

A cross-sectional study of 69,138 preschoolers in Longhua District, Shenzhen, China was conducted in 2022. Data on sociodemographic characteristics of families, bedtime, nighttime sleep duration of preschoolers, and their anxiety symptoms (measured by the Spence Preschool Children Anxiety Scale) were collected through a structured questionnaire completed by the parents. Using binary logistic regression models, the relationship between bedtime, nighttime sleep duration, and childhood anxiety symptoms was examined.

Results

The bedtimes of preschoolers were concentrated between 21:01–22:00 (52.41%). Among the preschoolers, 38.70% had bedtimes later than 22:00, and 75.49% had insufficient nighttime sleep duration. The positive screening rate for anxiety symptoms among preschoolers was 3.50%. After adjusting for confounding factors using binary logistic regression models, compared with preschoolers with bedtime ≤21:00, The OR (95%CI) values of anxiety in preschoolers with bedtime ≥23:01, 22:01–23:00 and 21:01–22:00 were 2.86 (2.21–3.69), 1.51 (1.27–1.79) and 1.48 (1.26–1.76), respectively. Compared with those with sufficient nighttime sleep duration, the OR (95%CI) of children with nighttime sleep duration less than 9 h was 1.36 (1.23–1.51).

Conclusion

An association exists between bedtime and nighttime sleep duration in preschoolers and their anxiety symptoms. Preschoolers with 21:00 for bedtime and a nighttime sleep duration of 10 h may have lower anxiety symptoms. These findings support the importance of adequate sleep for preventing anxiety symptoms in children.
Acquisition of educational values at the Real Madrid Foundation’s social-sports schools
Authors: Ortega-Vila Gema , Ortega-Toro Enrique , Giménez-Fuentes-Guerra Francisco Javier , Robles-Rodríguez José , Alarcón-López Francisco , Abad-Robles Manuel Tomás
Published: January 2024

The objective of this study was to analyse the impact of the educational programme of the Real Madrid Foundation (RMF) on the acquisition of educational values at social-sports football and basketball schools among children aged between 12 and 16 years in Italy, Romania, Spain and the United Kingdom. The most significant results showed that: (a) between the 20–21 and 21–22 seasons, there were statistically significant increases in personal and team success, self-fulfilment, personal and group superiority, health and physical fitness, and peaceful behaviour; and (b) the increase in variables being studied was different according to the country analysed in such a way that: in the per-sonal and team success dimension there was a rise in the United Kingdom and Italy; in self-fulfilment there was an increase in the United Kingdom; in the personal and group superiority dimension there was a rise in Italy and Romania; in the health and physical fitness dimension there was an increase in social-sports schools in the United Kingdom and Italy; in the peaceful behaviour dimension there was a rise in social-sports schools in the United Kingdom and a drop in social-sports schools in Romania. There were very significant improvements in the majority of dimensions and countries, although the development of the various dimensions is different and specific to every one of the distinct countries, meaning that it is necessary to keep adapting the educational programme of the Real Madrid Foundation in line with the sociocultural characteristics of each of the countries in which it is implemented.
Effect of computerized cognitive training on mood, cognition, and serum brain-derived neurotrophic factor level in late-life depression — a pilot randomized controlled trial
Authors: Ma Suk Ling , Tang Katsie Tung , Lau Niki Cheuk Ting , Chiu Clement Lek Hin , Lin Cuichan , Lam Linda Chiu Wa , Lee Allen Ting Chun
Published: January 2024

Background

The aim of this pilot randomized controlled trial was to test the feasibility of a computerized cognitive training targeting executive dysfunction in late-life depression and to investigate its impact on mood, cognition, and brain-derived neurotrophic factor (BDNF) levels.

Methods

A total of 28 community-living Chinese individuals aged 55–75 with moderate-to-severe depression and cognitive symptoms (but without mild cognitive impairment or dementia) were recruited from a community centre in Hong Kong. Participants were randomly allocated to either the experimental (receiving computerized cognitive training) or the control group (receiving computer-based health education). Both programs lasted for one hour and were conducted twice a week for 6 weeks at the community centre. We assessed mood using the Hamilton Rating Scale for Depression (HAM-D) and Patient Health Questionaire-9 (PHQ-9), cognition using the Montreal Cognitive Assessment (MoCA), and serum BDNF levels at baseline and follow-up. We performed repeated measures analysis of variance to compare the differences in outcome changes between groups and correlation analysis to test if changes in mood and cognition correlated with changes in BDNF level.

Results

Our sample had a mean age of 66.8 (SD = 5.3) years, a mean HAM-D score of 19.4 (SD = 7.5), and a mean PHQ-9 score of 18.0 (SD = 6.3). No adverse effects were reported. Significant differences were observed between the experimental and control groups in changes in HAM-D (-8.4 vs. -2.9; group difference = -5.5; p = 0.01), PHQ-9 (-6.6 vs. -0.6; -6.0; p < 0.001), MoCA (1.4 vs. -1.3; 2.7; p = 0.001), and serum BDNF levels (in pg/ml; 2088.3 vs. -3277.4; 5365.6; p = 0.02). Additionally, changes in HAM-D, PHQ-9, and MoCA scores correlated significantly with changes in BDNF level.

Conclusion

With computerized cognitive training improving mood and cognition and increasing serum BDNF levels in 6 weeks, it may serve as a safe and effective evidence-based alternative or adjuvant treatment for late-life depression.

Clinical trial registration

https://www.chictr.org.cn/indexEN.html, identifier ChiCTR1900027029.
Prevalence of chronic kidney disease and metabolic related indicators in Mianzhu, Sichuan, China
Authors: Chen Feng , Wang Miao , Jiang Yan
Published: January 2024

Background

Chronic kidney disease (CKD) is a major public health problem worldwide. Periodic surveys are essential for monitoring the prevalence of CKD and its risk factors. We assessed the prevalence of CKD and its risk factors in Mianzhu City in 2020.

Method

The Natural Population Cohort Study surveyed 7,770 individuals aged>20 years in Mianzhu City of Sichuan province in 2020. Our investigation encompassed the measurement of CKD prevalence, the evaluation of various renal function indicators, and comparisons based on age, gender, and hukou status. Additionally, some metabolic indices were also measured to identify the underlying causes of CKD.

Results

(1) Overall, the prevalence of reduced renal function (eGFR<60 mL/min/1.73m2), albuminuria, and CKD were 1.3, 10.0, and 10.4%, respectively, (2) the overall prevalence of CKD was higher among men than among women (14.5% vs. 8.6%). Similarly, the prevalence of CKD was higher among men than women in most age groups, (3) among urban residents, the prevalence of CKD was higher among middle-aged individuals and lower among young individuals and older adults, and (4) considering eGFR, the albuminuria and CKD for group definition, Blood pressure, triglyceride, high-density lipoprotein, blood sugar, and BMI were all statistically different among between normal groups and abnormal groups s in the albuminuria and CKD.

Conclusion

The incidence of CKD greatly varied between Mianzhu City and other regions in China and other countries. The differences in risk factors of CKD should be explored in the future. The gender difference in the prevalence of CKD in this study was markedly different from that in previous studies. More high-quality studies are needed to further explore this controversy. Based on the different prevalence of CKD and metabolism-related indices in rural and urban areas in this study, we speculated that the high incidence of CKD in Mianzhu City might be related to diet, lifestyle, and availability of healthcare services.
Urban green space visitation and mental health wellbeing during COVID-19 in Bangkok, Thailand
Authors: Arifwidodo Sigit D. , Chandrasiri Orana
Published: January 2024

Urban green spaces offer numerous benefits, and their role in supporting mental health, particularly during global crises such as the COVID-19 pandemic, is of growing interest to researchers and policymakers. This study explored the relationship between urban green space visitation and mental health well-being during the COVID-19 pandemic in Bangkok, Thailand. This cross-sectional study, conducted in Bangkok during the COVID-19 lockdown, used a telephone survey of 579 respondents. A logistic regression model was employed to examine the association between urban green space visitation and the WHO-5 mental health well-being score, considering various factors such as socioeconomic variables, healthy behaviors, and COVID-19-related experiences. The findings revealed a significant association between urban green space visitation during the lockdown and higher mental health well-being. Socioeconomic variables and healthy behaviors of respondents were also notably linked to higher WHO-5 mental health well-being scores. These findings collectively indicate that urban greenspace visitation serves as a crucial determinant of mental health and well-being, especially during the COVID-19 pandemic.
Assessing COVID-19 knowledge, attitudes, and practices among hospital employees: identifying sociodemographic determinants for improved public health strategies
Authors: Aljasim Layla , Javed Nargis Begum , Cordoba Carlos , Alyaseen Haider , Aljasim Batool , Aljasim Mariam , Cordoba Magdalena , Bugis Bussma A. , Al-Mohaithef Mohammed
Published: January 2024

Background

The working environment of healthcare institution during pandemic puts all hospital employees at high-risk of being exposed to contagious infections. An individual’s behavior and response are largely determined by their level of knowledge, attitudes and practices (KAP) toward a disease. Therefore, the present study aimed to evaluate and assess the KAP toward COVID-19 among hospital employees working in various positions and to identify the sociodemographic determinants associated with the level of KAP.

Methods

A cross-sectional survey was conducted from July 1 to July 15, 2020 in Almoosa Specialist Hospital, Alhasa, Eastern Province, Saudi Arabia in which 221 hospital employees with varied job titles participated. The data for demographics and history of COVID-19 exposure, KAP related to COVID-19 spread and prevention were collected online using a web-based platform (Survey Monkey). Student’s t-test/One-way ANOVA were used to compare total mean and standard deviation of KAP scores with demographic profiles and history of exposure.

Results

89.1% employees knew that COVID-19 virus is mostly transmitted from human-to-human, and 76.0% employees acknowledged droplet transmission. 64.7% employees preferred to take a sick person with unconfirmed COVID-19 to a health facility. Physicians had higher knowledge scores for COVID-19 infection and non-medical employees had the lowest scores (7.47 ± 1.23 and 6.47 ± 1.44, respectively). Nurses had the highest practice scores and non-medical employees lowest practice score (6.16 ± 0.74 and 5.37 ± 1.14, respectively). Attitude scores were similar among all the employees. All employees reported an increase in hand-washing frequency and physical contact avoidance.

Conclusion

The study results revealed socio-demographic factors; level of education, nationality, and field of service are associated with COVID-19 KAP. The study highlights that there is a gap in the level of knowledge about COVID-19, especially among nonmedical employees. Targeted interventional programs need to be planned and implemented to improve COVID-19 awareness among non-medical employees.
Contribution of radioactive particles to the post-explosion exposure of atomic bomb survivors implied from their stable chromosome aberration rates
Authors: Ohtaki Megu , Otani Keiko , Yasuda Hiroshi
Published: January 2024

Even today when nearly 80 years have passed after the atomic bomb (A-bomb) was dropped, there are still debates about the exact doses received by the A-bomb survivors. While initial airborne kerma radiation (or energy spectrum of emitted radiation) can be measured with sufficient accuracy to assess the radiation dose to A-bomb survivors, it is not easy to accurately assess the neutron dose including appropriate weighting of neutron absorbed dose. Particularly, possible post-explosion exposure due to the radioactive particles generated through neutron activation have been almost neglected so far, mainly because of a large uncertainty associated to the behavior of those particles. However, it has been supposed that contribution of such non-initial radiation exposure from the neutron-induced radioactive particles could be significant, according to the findings that the stable chromosomal aberration rates which indicate average whole-body radiation doses were found to be more than 30% higher for those exposed indoors than for those outdoors even at the same initial dose estimated for the Life Span Study. In this Mini Review article, the authors explain that such apparently controversial observations can be reasonably explained by assuming a higher production rate of neutron-induced radioactive particles in the indoor environment near the hypocenter.
Methane dynamics in vegetated habitats in inland waters: quantification, regulation, and global significance
Authors: Bodmer Pascal , Vroom Renske J. E. , Stepina Tatiana , del Giorgio Paul A. , Kosten Sarian
Published: January 2024

Freshwater ecosystems, including lakes, wetlands, and running waters, are estimated to contribute over half the natural emissions of methane (CH4) globally, yet large uncertainties remain in the inland water CH4 budget. These are related to the highly heterogeneous nature and the complex regulation of the CH4 emission pathways, which involve diffusion, ebullition, and plant-associated transport. The latter, in particular, represents a major source of uncertainty in our understanding of inland water CH4 dynamics. Many freshwater ecosystems harbor habitats colonized by submerged and emergent plants, which transport highly variable amounts of CH4 to the atmosphere but whose presence may also profoundly influence local CH4 dynamics. Yet, CH4 dynamics of vegetated habitats and their potential contribution to emission budgets of inland waters remain understudied and poorly quantified. Here we present a synthesis of literature pertaining CH4 dynamics in vegetated habitats, and we (i) provide an overview of the different ways the presence of aquatic vegetation can influence CH4 dynamics (i.e., production, oxidation, and transport) in freshwater ecosystems, (ii) summarize the methods applied to study CH4 fluxes from vegetated habitats, and (iii) summarize the existing data on CH4 fluxes associated to different types of aquatic vegetation and vegetated habitats in inland waters. Finally, we discuss the implications of CH4 fluxes associated with aquatic vegetated habitats for current estimates of aquatic CH4 emissions at the global scale. The fluxes associated to different plant types and from vegetated areas varied widely, ranging from−8.6 to over 2835.8 mg CH4 m−2 d−1, but were on average high relative to fluxes in non-vegetated habitats. We conclude that, based on average vegetation coverage and average flux intensities of plant-associated fluxes, the exclusion of these habitats in lake CH4 balances may lead to a major underestimation of global lake CH4 emissions. This synthesis highlights the need to incorporate vegetated habitats into CH4 emission budgets from natural freshwater ecosystems and further identifies understudied research aspects and relevant future research directions.
Sport officials’ use of observational learning
Authors: Hancock David J. , Rymal Amanda M.
Published: January 2024

Introduction

Observational learning is a key tool for improving skilled performances. Sport officials (e.g., referees, umpires, and judges) might glean particular benefits from using observation, as most officials do not engage in traditional practice. Unfortunately, little is known about how observational learning can be of benefit to sport officials. Thus, the purpose of this study was to take an exploratory approach to learn more about sport officials' use of observation.

Methods

Participants included 206 sport officials (170 male, 35 female, 1 not specified) from 17 sports (mainly ice hockey, soccer, lacrosse, and volleyball). Sport officials completed a 50-question online survey regarding their use of observational learning. Survey questions revolved around the reasons for using observation (e.g., to learn about positioning or rule application), along with when and how participants used observation (e.g., before versus after competitions; watching an unskilled versus skilled model).

Results

Participants used observation most frequently to learn knowledge and application of rules, personality and game management, and fitness and positioning/mechanics. Results revealed that participants preferred to use observation after their competitions, while watching other sport officials in-person, and while observing a skilled model who was correctly executing their tasks.

Discussion

In the discussion, we expand on the results, connecting it to previous research in sport officiating or observational learning. Lastly, we offer suggestions for future researchers that should help build our understanding of sport officials' use of observation.
Lidocaine constant rate infusion in isoflurane anesthetized neonatal foals
Authors: Lambertini Carlotta , Spaccini Francesca , Mazzanti Alessia , Spadari Alessandro , Lanci Aliai , Romagnoli Noemi
Published: January 2024

Introduction

In horses, lidocaine infusion is administered intraoperatively for analgesia and for a reduction of inhalant anaesthetic requirement. The objective of the study was to describe the anaesthetic effects of lidocaine infusion in isoflurane anaesthetised foals.

Methods

Twelve foals (<3 weeks old) undergoing surgery were included in the study (LIDO group). Foals were premedicated with midazolam and butorphanol IV, anaesthesia was induced with ketamine and propofol IV and maintained with isoflurane. Lidocaine was administered intraoperatively at 0.05 mg/kg/min. Also, the anaesthetic records of 11 foals in which lidocaine was not administered intraoperatively were retrospectively evaluated and they were considered as a historical control group (HC). Heart rate (HR), mean arterial pressure (MAP) and fraction of expired isoflurane were monitored continuously. Time of extubation, time to reach sternal recumbency and standing were recorded. The quality of recovery was assessed.

Results

HR decreased in both groups compared with baseline values and intraoperatively the differences were statistically significant (p = 0.01 and p = 0.03 respectively in the LIDO and HC groups). Intraoperatively the HR was significantly lower in the LIDO group (71.2 ± 13.4 bpm) compared with the HC group (87.1 ± 17.7 bpm) (p = 0.0236). The number of foals requiring inotropic support (LIDO n = 7 and HC n = 9) was not statistically associated with the treatment group (p = 0.371). The extubation time, the time to reach the sternal recumbency and the quality of recovery did not differ significantly between the two groups (p = 0.7 and p = 0.6 respectively).

Discussion

In conclusion, in anaesthetised foals the addition of lidocaine does not provide a sparing effect on isoflurane requirement, and it does not interfere with the quality of recovery, however it decreases significantly the HR, which is pivotal in foals for the maintenance of cardiac output and peripheral perfusion. Therefore, a continuous patient monitoring is essential.
The Flavor Characterization of ‘Huyou’ (Citrus changshanensis) Essential Oils Extracted by Conventional and Novel Methods
Authors: Cheng Huan , Liu Feifei , Zhang Yanru , Ye Zhiyue , Chen Jin , Chen Shiguo , Ye Xingqian
Published: January 2024

The aroma of citrus is among the most appealing natural flavors. ‘Huyou’ (HY) is a hybrid citrus with a unique flavor compared to grapefruit (GF), but few studies have analyzed its characteristic flavor comprehensively. In this study, we extract six essential oils (EOs) from HY and GF peels by cold pressing (CP) and microwave-assisted hydrodistillation (MADH) and spinning cone column (SCC). Further, the flavor of six EOs was investigated by using flavoromics analysis, including e-nose, GC-MS and GC-O combined with chemometric approaches. The results showed that CP EOs exhibited a stronger citrus characteristic flavor, while MADH and SCC EOs contained more diverse volatiles. A total of 23 key odorants were identified in the GC-O-MS analysis, 12 of which were specific to HY. The flavor wheel and partial least squares regression (PLSR) revealed that floral, sweet and fruity odors were positively correlated with linalool, α-terpineol and geraniol, while fatty, green and woody odors with germacrene D, germacrene B and nootkatone. Additionally, based on orthogonal partial least squares discriminant analysis (OPLS-DA), six aroma-active compounds were screened as aroma markers to distinguish HY from GF; i.e., γ-terpinene, D-limonene, germacrene D, nootkatone, germacrene B and terpinolene. The extraction methods and citrus varieties both impact the flavor characterization of citrus EOs, and our study provides guidance on the extraction and application for citrus EOs.