bluuebunny/crossref_metadata_2025 huggingface dataset:
FORMATION IN FUTURE ELEMENTARY SCHOOL TEACHERS READINESS TO WORK WITH PARENTS OF STUDENTS USING COACHING TECHNIQUES
Authors:   Volodymyr Vynnychenko Central Ukrainian State Pedagogical University, Androsova Natalia
Published: October 2022

One of the components of a teacher's readiness for professional activity is his mastery of various educational and upbringing technologies. Coaching techniques develop the potential of people and teams on the basis of subjectivity, reveal the inner potential of the individual, contribute to the achievement of pre-agreed goals, self-generation of optimal ways and methods of achieving goals, self-assessment, monitoring and monitoring tasks, change behavior patterns, implement educational process. In terms of improving the preparation of future elementary school teachers in partnership with parents of primary school children, we pay attention to the use of coaching technologies in the work of teachers with parents and in vocational education. Coaching technology is new for future elementary school teachers, as it is practically not used in work with younger students. However, in working with parents of students, this technology is effective in terms of taking into account the peculiarities of interaction with adults who already have some life experience. The advantage of using coaching technology in working with parents of elementary school children is that it helps adult participants in the educational process to independently determine the goals of activities, quickly find ways to solve difficult situations in the upbringing and development of children based on their own experiences. The article reveals the components of the readiness of primary school teachers to work with parents of primary school children (value- motivational, cognitive, activity-operational and reflective) and gives examples of the use of coaching techniques (transformational conversation, "Cartesian questions"), case studies, R. Dilts ", method" SWOT ", techniques" What if? ") In teaching students of pedagogical specialties in order to achieve professionalism of teachers in further communication with participants in the educational process. Further research should be aimed at detailing the topics of educational and life situations that will inevitably arise in the pedagogical career of working with parents.
CORRECTION OF ATTENTION OF SCHOOLCHILDREN WITH SPECIAL NEEDS BY MEANS OF MUSICAL AND INTONATIONAL INVENTION
Authors:   Anatoly Avdiyevsky National Pedagogical Dragomanov University, Biedna Yuliia
Published: October 2022

The article is devoted to the consideration of means of musical-intonational suggestion for the correction of attention of students with autism spectrum disorders. This correction method is presented in light of its potential to improve the general psycho-emotional state of students with appropriate nosology, which has a positive effect on the mental development of such children by improving the functioning of cognitive mental processes, including voluntary attention. Emphasis is placed on the psychological patterns of perception of a musical work in the process of pedagogical work with autistic children, which in the context of our theoretical study sheds light on the mechanisms of facilitating and intensifying the formation of attention processes during pedagogical interaction in class. The unique ability of music to change and adjust the emotional state of a student with special educational needs in combination with intonationally emphasized verbal instructions of the teacher allow arbitrary management of his educational and cognitive activities, which in turn "pulls" the development of attention and attention of such students. It is determined that to achieve the desired effect in creating a situation of music perception by children with autism, it is necessary to take into account their current emotional state at the beginning of music, their level of mental mobilization, activity, and plan and practice teacher behavior, including expression, pauses, intonations , gestures, facial expressions, selection of information material of the lesson. The function of suggestion for a certain category of children should be aimed at the child's perception of certain kinds of thoughts, positive feelings that directly affect the psyche and, accordingly, become a corrector of its attention. It is proved that the musical- intonational content of pedagogical interaction derives its potential from many sources of non-special content, and its expressiveness is based on associations with other sound sources due to auditory experience, which are prerequisites for psychophysiological influence of music on the child's emotional sphere. As a result of the conducted analytical work it is proved that the process of suggesting musical intonation for autistic children of primary school age is an important suggestive factor that allows to achieve the desired effect in the functioning of their cognitive mental processes.
Comparison of Surgical Outcomes of ventriculoperitoneal (VP) Shunt at Choudhary’s Point vs. Keen’s Point
Authors: Rana Zubair Mahmood  , Faheem Ahmed Usmani  , Mukhtiyar Ahmed Lakho  , Talha Abbas  , M. Yasin Khan  , Sarfraz Khan  , Touqeer Ahmed
Published: October 2022

Objectives:  The study compared the outcomes of VP shunt at Choudhary’s vs Keen’s point.

Material and Methods:  A quasi-observational study was conducted on 50 patients who presented to NS-2, PINS, with the complaint of hydrocephalus. The study was conducted for 3 months from 1st November 2021 to 31th Jan 2022.

Results:  Mean age was 40 years. In 25 (50%) patients, VP shunts were done through Choudhary’s point while in 25 (50%) patients VP shunts were done through Keen’s point. All patients were evaluated on day 3rd POD, 7th POD, 15th POD, and 90th POD.  All patients were improved on 3rd POD. On the 7th POD, 15 (30%) patients deteriorated and showed signs of raised ICP. In these patients, the upper end of VP shunts is again revised due to blockage. On 15th POD, the upper end of VP shunts was blocked in 3 (6%) patients and their upper end was revised. On 90th POD, 2 (4%) patients were presented with upper-end blockage, and again shunt revision was done.  VP shunts in all these patients were done through keen’s point approach. Blockage of the lower end of VP shunt occurred in 10% of patients in which 8% were operated through Keen’s point approach while resting 2% of patients were operated through Choudhary’s point approach. 

Conclusion:  VP shunts through Choudhary’s point approach yield good results as compared to Keen's point approach. This site is described by professor Muhammad Anwar Choudhary, as more convenient for insertion of VP shunt.
Comparison of Cerebrospinal Fluid Leakage in Endoscopic Endonasal Transsphenoidal Surgery for Pituitary Adenoma with and without Sellar Floor Reconstruction
Authors: Majeed Muhammad Naveed , Sumira Kiran  , Tariq Imran Khokhar  , Mubashir Malik  , Zubair Mustafa Khan  , Asif Bashir
Published: October 2022

Objectives:  This study aimed to compare CSF leak in endoscopic endonasal TSS of pituitary adenoma with and without reconstruction of the sellar floor with no intraoperative CSF leakage.
Materials and Methods:  It was a randomized controlled trial of 116 patients of both genders diagnosed case of pituitary adenoma who underwent endoscopic endonasal TSS over 1 year. The cases were randomized into 2 groups. In Group A endoscopic endonasal TSS and the sellar floor, reconstruction was done while in Group B only endoscopic endonasal transsphenoidal surgery was done without reconstruction.
Results:  The patient’s mean age in group A was 40.7 ± 9.56 years, and in group, B was 41.9 ± 10.5 years. The gender distribution, for group A, males and females were 29 each (50%) and in group B, the males were 36 (62%) and females were 22 (38%). There were 52 (89.7%) cases of macroadenoma and 6 (10.3%) cases of microadenoma in each group. On the 1st postoperative day, CSF leakage was noted in 2 (3.4%) patients of group A, and CSF leakage was observed in 2 (3.4%) patients of group B. Results revealed no difference in CSF leakage between both groups. There were minor nasal complications in both groups.
Conclusion:  There is an equal chance of success with endoscopic endonasal transsphenoidal surgery (TSS) of pituitary adenoma with and without reconstruction of the sellar floor, concerning post-operative CSF leak, in patients who have no intraoperative CSF leak which enlarges the pool of options for treatment.
The Influence of Epidural Steroids on Postoperative Pain and Hospital Stay in Patients Having a Single-Level Lumbar Discectomy
Authors: Shah Khalid  , Abdul Aziz khan  , Faiza Khalid  , Shahbaz Ali Khan  , Abdul Majid
Published: October 2022

Objective:   In this study, we looked at how intra-operative epidural steroids affected postoperative pain and stay duration in patients with unilateral single-level lumbar discectomy.

Material & Methods:  A randomized control trial was conducted at Ayub Teaching Hospital Abbottabad. Group A (n = 30) was given intraoperative epidural methylprednisolone, while group B (n = 30) was given normal saline only. The outcome was measured between the two groups in terms of postoperative pain (visual analog scale), time of mobilization, length of hospital stay, and duration to return to work.

Results:  At discharge, the VAS score in group A was 0.40 compared to 2.4 in group B (p = 0.000). At 2 weeks follow-up, the mean VAS score was 1.10 in group A in contrast to 1.4 in group B (p = 0.001). Patients who received local epidural methylprednisolone were mobilized after an average of 1 day, stayed for an average of 1.16 days, and returned to work following 18.2 days, whereas patients in the control group were mobilized after an average of 1.2 days, stayed for an average of 1.86 days and returned to work following 25.9 days. An incidental Dural tear occurs in 2 cases.

Conclusion:  Intra-operative epidural steroid is beneficial in reducing post-operative pain, hospital stay, and time to return to work. It allows early mobilization with enhanced recovery and few complications.
Predictors of Surgical Outcome Following Cerebral Contusion in Severe Head Injuries
Authors: Shahzaib Tasdique  , Diggaj Shrestha  , Zainab Sarwar  , Samra Majeed  , Obaid ur Rehman  , Waqas Mehdi  , Azam Niaz
Published: October 2022

Objective:  There are controversies regarding the management of Cerebral Contusion. The study sought to identify parameters influencing the surgical outcome of individuals suffering from a brain contusion.

Methods:  A quasi-experimental study was conducted at the Department of Neurosurgery, Mayo Hospital Lahore, and 37 patients were included. The information on the mode/mechanism of injury, time of presentation, clinical presentation, and contusion type/location was collected. GCS (at 1st, 2nd and 6th weeks) and GOS were used for the neurological assessment of pre-operative and post-operative status.

Results:  The average age of presentation was 42.57 years. There were 21.6% female and 78.4% male patients. 64.9% presented with road traffic accidents. 4% of patients presented to the hospital within 12 hours of injury, 16.2% between 12 to 24 hours, and 5.4% between 24 to 48 hours. 29% had seizures and upgoing plantar. 18% had hemiparesis or hemiplegia. Light reflex was absent in 40.5% of patients. The GCS kept improving postoperatively. GCS at admission was averaging 8 which improved to 10, 12, and 13 after surgery. The presenting mean GCS at 1st-week, 2nd-week, 6th-week, and mean GOS at 30th PAD. Counter coup injury improved to 15/15 right in 1st week. Mean GOS was 5 at 30th PAD. The most improvement was seen in the frontoparietal, temporoparietal, and fronto-temporo-parietal locations. The mean GOS at 30th PAD was 4.

Conclusion:  The outcome following cerebral contusion depends upon the initial presenting GCS and GOS. Therefore, the better the presenting GCS and GOS better is the prognosis of the patient.
RESPONS PETANI TERHADAP PROGRAM PERLUASAN AREAL TANAM BARU (PATB) PADI DI KECAMATAN POLOKARTO KABUPATEN SUKOHARJO
Authors: Vionita  , Suwarto  , Rusdiana Eksa
Published: October 2022

Abstrak

 

Program Perluasan Areal Tanam Baru (PATB) Padi merupakan program pemerintah tahun 2020 dalam rangka meningkatkan produksi padi di masa pandemi. Program ini memiliki tujuan untuk menjaga daya beli petani di pedesaan yang terkena dampak Covid-19. Untuk mengantisipasi kelangkaan pangan serta memastikan adanya kecukupan stok beras nasional. Tujuan penelitian ini untuk mengkaji respons petani atas program PATB Padi di Kecamatan Polokarto dan mengkaji hubungan karakteristik petani dengan respons petani atas program PATB Padi di Kecamatan Polokarto. Penelitian ini dengan metode tekniksurvei  kuantitatif. Penentuan lokasi penelitian secara sengaja (purposive) yaitu Kecamatan Polokarto, Kabupaten Sukoharjo. Pengambilan sampel ditentukan dengan teknik proportional stratified random sampling yaitu sebanyak 62 responden. Teknik pengumpulan data penelitian ini dengan wawancara melalui kuisioner, observasi serta dokumentasi. Analisis data dengan uji analisis deskriptif dan uji Rank Spearman dengan IBM SPSS 25. Hasil penelitian ini menunjukkan bahwa respons petani terkait program PATB termasuk dalam kategori rendah sebesar 51,61%. Adanya hubungan signifikan antara pendidikan nonformal dan pendapatan dengan respons petani. Adanya hubungan tidak signifikan antara umur, pendidikan formal, luas lahan dan pengalaman usahatani dengan respons petani PATB.

 

Kata Kunci: Respons Petani, Karakteristik Petani, Program PATB
ANALISIS PENDAPATAN DAN TINGKAT KEUNTUNGAN PENCARI CACING SUTRA Tubifex SP
Authors: Faisal Herry Nur
Published: October 2022

ABSTRAK

 

Perikanan menjadi salah satu pilar penting dalam pemajuan perekonomian nasional, perikanan memiliki peluang yang baik untuk bisa dipergunakan sebagai stimulus peningkatan perekonomian masyrakat.  Cacing sutra merupakan komoditi yang menjajikan karena Cacing Sutra merupakan pakan organik untuk Ikan Air Tawar yang masih muda. Pengembangan Cacing Sutra sangat pesat dari Kabupaten Tulungagung sendiri. Cacing Sutra berhabitat di Sungai DAS aliran sungai Brantas yaitu salah satunya sungai di Desa Wajak Lor,dikarenakan sungai di Wajak memiliki arus yang tidak begitu deras dan tempat pembuangan limbah home industri tempe, dan tahu, limbah ampas tahu dan tempe sangat di minati Cacing Sutra untuk berhabitat. Di Desa Wajak banyak sekali para pencari Cacing sutra selain untuk pakan Ikan sendiri juga untuk pekerjaan sampingan warga Desa Wajak Lor untuk menambahkan pendapatan sehari – hari. Oleh karena itu seorang pengusaha atau seorang pencari Cacing Sutra harus mempunyai suatu Alat untuk mengukur tingkat kelayakan finansial dan non finansial.

Kata Kunci: cacing sutra, keuntungan, pendapatan
ANALISIS BAMBU SEBAGAI STRUKTUR BALOK BANGUNAN RUMAH TINGGAL BERTINGKAT
Authors: Aditya Purnama  , Imam Suyadi
Published: October 2022

Abstract
Bamboo material is a renewable natural product that can be obtained easily, cheaply, easily planted, grows fast, can reduce the effects of global warming, and has a very high tensile strength that can be competed with steel. Bamboo is a material that is commonly found in several villages and mountainous areas in Tulungagung, therefore bamboo material has a relatively cheap price.
Loading reviews dead load and lives load. The analysis carried out in this study is loading, calculating the ultimate moment, normal force, and transverse force, then planning the bamboo beam against bending, tensile and compressive axial forces, and planning the shear of the bamboo beam. Then the bamboo beam is controlled against the combined axial bending load.
Based on the results of the analysis and planning calculations, it was obtained that a bamboo beam with a stretch of 5 meters required 3 pieces of bamboo used to resist bending, and 2 pieces of bamboo needed as diagonal support. The bamboo used is bamboo with a diameter of 10 cm with a bamboo wall thickness of 1 cm.
 Keywords: Bamboo; beam; renewable; analysis; design
Abstrak
Material bambu merupakan produk hasil alam yang renewable yang dapat diperoleh dengan mudah, murah, mudah ditanam, pertumbuhan cepat, dapat mereduksi efek global warming serta memiliki kuat tarik sangat tinggi yang dapat dipersaingkan dengan baja. Bambu merupakan material yang banyak ditemui di beberapa desa dan daerah pegunungan di Tulungagung, maka dari itu material bambu memiliki harga yang relatif murah.
Pembebanan meninjau beban mati dan beban hidup. Analisis yang dilakukan pada penelitian ini adalah pembebanan, menghitung momen ultimate, gaya normal, gaya lintang, kemudian merencanakan balok bambu terhadap lentur, gaya aksial tarik dan tekan, dan merencanakan geser balok bambu. Kemudian balok bambu dikontrol terhadap beban kombinasi aksial lentur.
Berdasarkan hasil dari perhitungan analisis dan perencanaan diperoleh hasil balok bambu dengan bentangan 5 meter diperlukan bambu yang digunakan untuk menahan lentur sebanyak 3 buah, bambu yang diperlukan sebagai diagonal support sebanyak 2 buah. Bambu yang digunakan ialah bambu dengan diameter 10 cm dengan ketebalan dinding bambu 1 cm.
Kata Kunci: Bambu; balok; renewable; analisis; perencanaan
Avaliação da formação dos componentes secundários da cachaça durante o processo fermentativo
Authors: Machado Bárbara Dias , Conceição Elaine Cristina da , Teixeira Thatiane Magalhães , Machado Alan Rodrigues Teixeira
Published: October 2022

A cachaça é um produto típico do Brasil que vem ganhando espaço no mercado. Ela é obtida pela destilação do mosto fermentado do caldo de cana-de-açúcar e seu processo de produção pode ser resumido em: preparação dos insumos, extração do caldo, fermentação e destilação. Durante a fermentação alcoólica, são formados álcoois, dióxido de carbono e outros compostos secundários que são responsáveis pelo aroma e sabor dos destilados. Sendo assim, o objetivo deste trabalho foi avaliar a formação desses compostos durante o processo fermentativo realizado em uma fábrica de cachaça localizada em Bom Jesus do Amparo – Minas Gerais. O processo foi acompanhado por 35 dias e a formação dos compostos orgânicos foi investigada em função do tempo. Além disso, foi observada a relação com os padrões estipulados pela legislação brasileira. Ao longo do estudo, foram obtidas variações significativas do produto final em alguns parâmetros, tais como: o aumento da acidez volátil e de ésteres totais e a redução dos álcoois superiores. Por outro lado, contaminantes orgânicos não foram registrados em quantidades significativas.
Pequenos negócios em tempos de Covid-19: impacto e estratégias de sobrevivência
Authors: Enes Wilson Machado
Published: October 2022

Desde seu início, a pandemia da COVID-19 modificou o padrão de consumo e a gestão das empresas, estimulou a inovação afetando a economia global. Em um breve espaço de tempo tudo mudou, e as empresas, principalmente de pequeno porte, não estavam preparadas para isso. O objetivo do estudo foi identificar e analisar os impactos da COVID-19 nos pequenos negócios do município de CláudioMG, bem como descrever as medidas que estão sendo adotadas neste período e estratégias que pretendem adotar no período pós-pandemia. Assim, foi feito um estudo de caso, com abordagem quantitativa e qualitativa, bem como pesquisa com finalidade descritiva. A coleta dos dados foi realizada por meio de questionários enviados por e-mail para pequenos empresários da cidade de Cláudio-MG, buscando compreender como os mesmos estão se ajustando à pandemia. Foi possível concluir que a inovação e o planejamento apresentaram-se como os maiores desafios aos empreendedores locais, visto que os mesmos passaram a analisar cenários e buscar soluções criativas para sobreviverem no mercado.
Análise da viabilidade técnica e econômica entre os sistemas construtivos Light Steel Framing e alvenaria estrutural em habitação de interesse social
Authors: Madeira Nathália Larissa Silva , Rezende Letícia Maria Venâncio , Junior Ladir Antonio Silva
Published: October 2022

Neste artigo é apresentada uma análise da viabilidade técnica e econômica entre os sistemas construtivos em alvenaria estrutural e Light Steel Framing (LSF), com o intuído de avaliar qual o melhor sistema para construções de residências unifamiliares. Tem -se como base para o estudo de caso o projeto padrão da Caixa Econômica Federal em alvenaria estrutural, já para LSF foi utilizado o projeto apresentado por Penna (2009). Utilizou-se como base a tabela SINAPI que apresenta as especificações do custo dos materiais, mão de obra e índice de produtividade, para execução dos orçamentos e cronogramas. Em relação as etapas referentes a estrutura e vedação dos dois sistemas construtivos, notou-se que o projeto em alvenaria estrutural possui vantagens em relação ao custo. Já em relação a viabilidade técnica, o projeto em LSF é o mais bem avaliado, decorrente da rápida execução e baixa geração de resíduos. Assim o LSF é o sistema mais recomendado para solucionar o problema do déficit habitacional no país, uma vez que a redução de tempo na execução pode chegar a 57% se comparado com a alvenaria estrutural, podendo ser construído com maior agilidade, permitindo a construção em grande escala.
Correlation Between Soil Nitrogen Content and NDVI Derived from Sentinel-2A Satellite Imagery
Authors: Trigunasih Ni Made , Saifulloh Moh
Published: October 2022

The United Nations Educational, Scientific, and Cultural Organization (UNESCO) has recognized the Balinese agricultural irrigation system known as subak as part of the world's cultural heritage. Subak is the driver of Bali’s agricultural and tourism sectors and, therefore, must be preserved. Population growth triggers the conversions of land functions, from subak to built-up lands, such as those transpiring in Denpasar City. On the other hand, with the population continuously increasing, the demand for food becomes inevitably higher. This has caused farmers to intensify their agricultural practices through, for instance, applying chemical fertilizers excessively-potentially decreasing soil fertility. An example is urea fertilizer that contains a macronutrient, i.e., nitrogen (N). This study aimed to analyze the soil N content and its correlation with rice growth using the Normalized Difference Vegetation Index (NDVI). The Kjeldahl method was conducted to measure the N levels in the soil laboratory. NDVI was extracted from remote sensing data, namely Sentinel-2A imagery, on a cloud computing platform, Google Earth Engine (GEE), using Band 8 (NIR) with a wavelength of 0.842 m and Band 4 (Red) with 0.665 m. The results showed that the N levels varied from 0.09% to 0.31% and the average NDVI values ranged from 0.47 to 0.54. There is a strong correlation (r = 0.75 to 0.78) between the NDVI values derived from the Sentinel-2A Satellite Imagery and the soil nitrogen content. Spatially, based on the analysis results of the 2019‒2021 data, parts of existing subak systems, i.e., Subak Kerdung, Mergaya, Padanggalak, and Sembung, have high soil N contents and NDVI values.
Evaluasi Kegiatan Corporate Social Responsibility (CSR) Terhadap Pengembangan Sosial Ekonomi Masyarakat Di PT. Holcim Indonesia Tbk. Pabrik Cilacap
Authors: Triyanto Bambang
Published: October 2022

Program Corporate Social Responsibility (CSR) PT. Holcim Indonesia Tbk. Cilacap Factory is intended for residents who live around the factory and mine sites. This program aims to improve living standards and income levels and improve the education of citizens, especially at school age. CSR programs also open job opportunities for the surrounding community in order to provide benefits and improve welfare. In general, CSR formats and concepts have been implemented by PT. Holcim Indonesia Tbk. Cilacap Factory is a combination of community relations and community empowerment. The implementation of this can be seen from the company's policy involving stakeholders in determining the program to be implemented in the CSR program. This format and concept already have planning documents and strategies for achieving targets because it is able to establish and empower the community. Corporate Social Responsibility programs that have been implemented by companies in the socio-economic development of the community are Posdaya, Infrastructure, Education, Social, Culture, Religion, and Environment. Posdaya activities have provided benefits in the economic field in the form of additional family income whereas before CSR activities the average income per month is Rp. 1,068,000.00 per month, and after CSR increased to Rp. 1,372,000.00 per month, or an increase of 9.6 percent. Other programs that have provided benefits for the surrounding community are in the field of infrastructure where there has been an absorption of labor from ongoing projects, as well as the availability of transportation access that makes it easier for people to market production results.
Wohnwort
Authors: Pisano Libera
Published: October 2022

Abstract: One aspect of Elazar Benyoëtz’s poetry is his bold attempt to treat the catastrophe of Auschwitz through a linguistic prism. In this essay, I would like to shed light on his way of inhabiting the German language as an outsider by considering the ethical implications of his bifurcated linguistic soul. To do so, I will first analyze the general representation of language that appears in Benyoëtz’s work. In particular, I will point to the dynamics of language and how its movement shapes a land and a language beyond all constraints of ownership, while providing an alternative way of inhabiting it. I will then examine possible interpretations of Benyoëtz’s bifurcated linguistic soul along with its ethical implications, including not only a coming to terms with the end of German-Jewish symbiosis, but also a utopian way of repairing it.
Differences of inflammatory microenvironment and sensitive correlation to cisplatin-chemotherapy in lung adenocarcinoma and squamous cell carcinoma
Authors: Cui Zhilei , Zhang Linlin , Song Lin
Published: October 2022

Introduction: Non-small cell lung cancer (NSCLC) is the most prevalent type of cancer worldwide and associated with high mortality rate. An effective treatment for NSCLC is urgently needed. This study aimed to investigate differences of inflammatory microenvironment and sensitive correlation to cisplatin-chemotherapy in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC), thereby providing insights into the mechanisms underlying inflammation in NSCLC.

Materials and methods: The resistance of A549 and SK-MES-1 cells to cisplatin treatment was determined by IC50. The migration and invasion capacity of A549 and SK-MES-1 cells was determined using migration and invasion assay kits. The apoptosis rate was evaluated. The protein expression levels of caspase-3 and Ki67 were measured by western blot. ELISA assay was used to determine the levels of inflammatory cytokines, including IL-4, IL-6, IL-8, and TNF-α.

Results: Patients with LUAD showed shorter survival than LUSC patients after the chemotherapy treatment. LUAD was more resistant to cisplatin treatment, corresponding with a higher IC50 observed in A549 cells than SK-MES-1 cells. Moreover, A549 cells showed higher migration and invasion capacity and lower apoptosis rate than SK-MES-1 cells. In addition, SK-MES-1 LUAD samples showed stronger inflammation response than LUAD samples and A549 cells. Accordingly, inflammation cytokines promoted the migration and invasion of SK-MES-1 cells, whereas inhibited cell apoptosis.

Conclusions: The present study suggests that LUAD is more resistant to chemotherapy and shows a stronger inflammation response than LUSC. Inflammatory cytokines could enhance the resistance of LUAD to chemotherapy and further promote tumor cell proliferation, migration, and invasion.
Comparison of Subfoveal Choroidal Thickness Values with Severity of Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients
Authors: Sandiyanto  , Weni Helvinda  , Kemala Sayuti
Published: October 2022

Background: Changes in choroidal thickness may be associated with increased severity of diabetic retinopathy and may occur simultaneously or even earlier than diabetic retinopathy. This study aims to compare the value of subfoveal choroidal thickness (SCT) with the severity of RD in patients with type 2 DM without RD with NPDR at Dr. M. Djamil General Hospital Padang, Indonesia.

Methods: This research is a cross-sectional analytic observational study. The study was conducted on 36 eyes obtained from 29 study subjects. Data analysis was performed with the help of SPSS to determine the ratio of SCT thickness in diabetic retinopathy patients, p<0.05.

Results: The thickest mean SCT value was found in the type 2 DM group without RD (328.78 + 14.78 mm) and the thinnest in the severe NPDR group (234,22 + 12,30 mm).

Conclusion: The more severe the severity of diabetic retinopathy, the thinner the SCT (subfoveal choroidal thickness).
Preliminary Group Classification of nonlinear wave equation utt + ut = f(x, ux)uxx + g(x, ux)
Authors: Masebe Tshidiso
Published: October 2022

The paper discusses the non-linear wave equations whose coefficients are dependent on first order spatial derivatives. We construct the principal Lie algebra, the equivalence Lie al- gebra, and the extensions by one of the princi- pal Lie algebra. We further construct the op- timal system of one-dimensional subalgebras for rst three extended five-dimensional Lie alge- bras. These are finally used to determine invari- ant solutions of some examples.
Efficient Ranking Function Methods for Fully Fuzzy Linear Fractional Programming problems via Life Problems
Authors: Mustafa Rebaz , Sulaiman Nejmaddin
Published: October 2022

In this paper, we propose two new ranking function algorithms to solve fully fuzzy linear fractional programming (FFLFP) problems, where the coefficients of the objective function and constraints are considered to be triangular fuzzy numbers (TrFN) s. The notion of a ranking function is an efficient approach when you want to work on TrFNs. The fuzzy values are converted to crisp values by using the suggested ranking function procedure. Charnes and Cooper’s method transforms linear fractional programming (LFP) problems into linear programming (LP) problems. The suggested ranking functions methods' applicability to actual problems of daily life, which take data from a company as an example, is shown, and it presents decision-making and exact error with the main value problem. The study aims to find an efficient solution to the FFLFP problem, and the simplex method is employed to determine the efficient optimal solution to the original FFLFP problem.
ON THE DOMINATION AND INDEPENDENT SETS OF G^M_{m,n} GRAPH
Authors: Sravanthi K. , Parvathi S.
Published: October 2022

In graph theory, the theory of domination has several applications in various fields of science and technology, which is considered as a turn up field of research. In real life, it is extremely important in fields like network desigh, wireless sensor networks,logistics, mobile computing, telecommunication and others, Problems with facility location, communication or electrical network monitoring can lead to dominance. Undirected graphs is one of the most excellent models in connection with distributed computation and parellel processing. A set $S\subset V$ is said to be a dominating set of a graph $G$ if every vertex in $ V-S $ is adjacent to atleast one vertex in $S$. The domination number $\gamma{(G)}$ of the graph $ G $ is the minimum cardinality of a dominating set of $ G $. An independent dominating set $ S \subset V $ is exists if no edges in the induced subgraph $\langle S \rangle$ and the independent dominating number $\gamma_i(G)$ is the minimum cardinality of an independent dominating set of $ G $. in this paper, some results on dominating sets and independent dominating sets of $\uppercase{G}^{M}_{m,n}$ graph on a finite sebset of natural numbers are presented and the domination numbers are obtained for various values of $m,n$.
Notas Históricas Sobre a Constituição de 1988
Authors: Carreiro Silva Raimundo
Published: October 2022

O decurso de três décadas de vigência de uma Constituição em regime democrático estável é, sem dúvida, um marco inédito na história brasileira.

Conquanto a Constituição de 1891, a primeira da República, tenha perdurado por quase quarenta anos, suas características não permitiam considerá-la como uma constituição democrática. Isso é ilustrado, por exemplo, pelo voto a descoberto, que alimentou o coronelismo por meio do “voto de cabresto”[1].

Embora a Constituição de 1934 tenha sido marcada por feições democráticas, sua vida foi curta. Em pouco tempo foi superada pela Constituição de 1937, outorgada por Getúlio Vargas, sob circunstâncias ditatoriais.

A Constituição de 1946 sobreviveu em ambiente democrático até a ruptura político-institucional de 1964, ou seja, não completou dezoito anos de vigência material em ambiente democrático[2].

 

[1]     O voto secreto foi formalmente instituído apenas com o Código Eleitoral de 1932. (BRASIL. Código Eleitoral de 1932. Disponível em: www.planalto.gov.br).

[2]     No plano formal, a Constituição de 1946 “sobreviveu” até a promulgação da Constituição de 1967, em 24 de janeiro daquele ano. Porém, segundo os próprios termos usados pela junta militar (autointitulada de “Comando Supremo da Revolução”), ao emitir o Ato Institucional n° 1, de 9/4/1964, o governo militar avocou um poder constituinte originário, embora mantivesse formalmente a Carta de 1946. Veja-se o que dizia ementa do AI 1/1964: “Dispõe sobre a manutenção da Constituição Federal de 1946 e as Constituições Estaduais e respectivas Emendas, com as modificações introduzidas pelo Poder Constituinte originário da revolução Vitoriosa.”
Tópicos de Liberdade na Jurisprudência Constitucional do Supremo Tribunal Federal
Authors: Mello Filho José Celso de
Published: October 2022

A celebração de uma data impregnada de relevo histórico e político. 2. O significado da defesa da Constituição. - 3. O Supremo Tribunal Federal, em tema de interpretação constitucional, quando no desempenho de sua atividade jurisdicional, tem o monopólio da última palavra, notadamente em sede de controle normativo abstrato. - 4. A proteção jurisdicional dos direitos humanos: um encargo irrenunciável do Supremo Tribunal Federal e de todos os órgãos integrantes do Poder Judiciário. - 5. Extradição e terrorismo. - 6. O acesso das pessoas em geral, inclusive de estrangeiros não domiciliados no Brasil, ao remédio constitucional do “habeas corpus” e à garantia constitucional do “due process of law”. - 7. A prerrogativa constitucional contra a autoincriminação e os atos de persecução estatal. - 8. A delação anônima nos procedimentos penais.
Consideraciones Breves Sobre Los Fundamentos de La Propuesta de Ley de Inteligencia Artificial de La Comisión Europea
Authors: Masseno Manuel David
Published: October 2022

Objetivo del estudio: poner a disposición de los parlamentarios mexicanos, y asimismo de los demás parlamentarios iberoamericanos, una síntesis informativa, crítica y contextualizada del procedimiento legislativo en marcha en la UE - Unión Europea con respecto a la regulación de la IA – Inteligencia Artificial, también de utilidad para los investigadores.

Metodología: fue seguido fundamentalmente el método histórico-jurídico, pero con aperturas hacia los métodos comparativo y hermenéutico.

Relevancia: expone como es viable pasar de un enfoque basado en principios hacia un enfoque basado en reglas, incluso en un campo tan nuevo y desafiante como la IA.

Resultados principales: expone las ventajas, y las debilidades, de un procedimiento descendiente en lo que concierne una tecnología del mayor riesgo, para la propia Humanidad, como la IA. 

 Contribuciones metodológicas: destaca como la UE mantuvo Valores constitucionales la Dignidad Humana, los Derechos Fundamentales y el Estado de Derecho por encima de cualquier criterio económico primario al legislar sobre IA, poniéndose como punto de referencia mundial.

Contribuciones sociales: intenta proporcional a los parlamentarios mexicanos, y asimismo de los demás parlamentarios iberoamericanos, referencias comparativas consistentes cuando están a punto de enfrentar los retos de la regulación de la IA.
Kontaktinė alergija augalinės kilmės alergenams: odos lopo mėginių su Europos bazinės serijos alergenais šešerių metų tyrimų analizė
Authors: Žemaitytė Julija , Linauskienė Kotryna , Malinauskienė Laura
Published: October 2022

Įvadas. Augalai – tai neatsiejama mūsų gyvenimo dalis, o augaliniai produktai tampa vis plačiau naudojami modernioje visuomenėje. Tačiau neretai augalinės medžiagos sukelia kontaktinį įsijautrinimą, kurio klinikinė išraiška – alerginis kontaktinis dermatitas. Alerginiam kontaktiniam dermatitui būdingi nespecifiniai odos išbėrimai, tad diagnozei pagrįsti, alergenui nustatyti indikuotina atlikti odos lopo testą. Tyrimo tikslas. Išanalizuoti kontaktinės alergijos augaliniams Europos bazinės serijos alergenams dažnių pokyčius 2015–2020 m. ir aptarti tiriamųjų demografinius ir klinikinius savitumus. Metodai. Į tyrimą įtraukti 1 970 dermatitu sergantieji, kuriems Vilniaus universiteto ligoninės Santaros klinikose atlikti odos lopo mėginiai Europos bazinės serijos alergenais. Rezultatai. 2015–2020 m. bendras kontaktinio įsijautrinimo dažnis Europos bazinės serijos alergenams siekė 55,22 proc. tarp dermatitu sergančių tiriamųjų. Įsijautrinimas augalinėms medžiagoms buvo didžiausias 2018 m., kai siekė 14,21 proc. Sensibilizacija Peru balzamui patvirtinta 7,05 proc., kanifolijai – 4,56 proc., seskviterpeno laktonų mišiniui – 0,81 proc. Įsijautrinimas augaliniams alergenams moterims pasireiškė 84,89 proc. patvirtintų kontaktinės alergijos atvejų. Sergantiesiems gretutinėmis alerginėmis ligomis kontaktinė alergija augaliniams alergenams patvirtinta 33,06 proc. atvejų. Dažniausiai įsijautrinimas augaliniams alergenams pasireiškė 30–39 metų amžiaus grupėje (27,02 proc.). Veido dermatitas nustatytas 40,81 proc., rankų – 25,30 proc., kojų – 6,12 proc. atvejų. Apibendrinimas. Kontaktinė alergija augaliniams alergenams statistiškai reikšmingai dažniau patvirtinama moterims ir esant atopinei anamnezei. Įsijautrinimo kanifolijai dažnis su amžiumi statistiškai reikšmingai mažėja. Dažniausia pirminė augalinių medžiagų sukelto alerginio kontaktinio dermatito sritis – veido oda. Įsijautrinimo dažnis Europos bazinės serijos alergenams – 55,22 proc., augalinėms medžiagoms – 11,55 proc. Dažnių pokyčiai 2015–2020 m. statistiškai nereikšmingi.
Budezonido, glikopironio ir formoterolio derinio veiksmingumas gydant LOPL
Authors: Malakauskas Kęstutis
Published: October 2022

Budezonidas / glikopironis / formoterolis (BUD / GLI / FORM) yra įkvepiamasis fiksuotų dozių gliukokortikoido, ilgai veikiančio muskarino receptorių blokatoriaus (IVMB) ir ilgai veikiančio β2 agonisto (IVBA) derinys, patvirtintas lėtinės obstrukcinės plaučių ligos (LOPL) palaikomajam gydymui. BUD / GLI / FORM sumažino vidutinio sunkumo ir sunkių LOPL paūmėjimų dažnį, pagerino plaučių funkciją labiau nei BUD / FORM ir (arba) GLI / FORM, taip pat pasireiškė dusulį lengvinamuoju ir su sveikata susijusiu gyvenimo kokybę gerinamuoju poveikiu. BUD / GLI / FORM sumažino mirtingumo dėl visų priežasčių riziką. BUD / GLI / FORM buvo gerai toleruojamas, o toleravimo profilis buvo panašus į atskirų šio derinio komponentų. BUD / GLI / FORM yra veiksmingas ir patogus LOPL palaikomojo gydymo pasirinkimas pacientams, kurių liga nepakankamai kontroliuojama naudojant įkvepiamojo gliukokortikoido / LABA arba LAMA / LABA derinį.
Nintedanibas veiksmingai lėtina FVC mažėjimą gydant sergančiuosius idiopatine plaučių fibroze, kitomis progresuojančiomis fibrozuojančiomis intersticinėmis plaučių ligomis bei su sistemine skleroze susijusia intersticine plaučių liga
Authors: Biekšienė Kristina
Published: October 2022

Nintedanibas – tai priešfibrozinis vaistas, viduląstelinis tirozino kinazės receptorių inhibitorius. Nintedanibas patvirtintas idiopatinės plaučių fibrozės, kitų progresuojančių fibrozuojančių intersticinių plaučių ligų ir su sistemine skleroze susijusios intersticinės plaučių ligos gydymui. Nintedanibas veiksmingai sulėtino gyvybinės plaučių talpos mažėjimą gydant šias plaučių ligas ir toks poveikis buvo ilgalaikis.
Структурно-текстурные и вещественные свойства сульфидных медно-никелевых руд.
Authors:   Геологический институт Кольского научного центра Российской академии наук, Никулин И. И. , Михайлова Ю. А. ,   Геологический институт Кольского научного центра Российской академии наук, Калашников А. О. ,   Геологический институт Кольского научного центра Российской академии наук, Грошев Н. Ю. ,   Геологический институт Кольского научного центра Российской академии наук, Степенщиков Д. Г. ,   Геологический институт Кольского научного центра Российской академии наук, Пахомовский Я. А. ,   Геологический институт Кольского научного центра Российской академии наук, Кадыров Р. И.
Published: October 2022

В книге приведены результаты изучения структурно-вещественных характеристик руд Норильского района. Использовались методы трехмерной рентгеновской томографии, локального анализа химического состава минералов, химического анализа пород, морфогеометрического анализа распределения рудных минералов. Выявлена взаимосвязь фрактальной размерности рудных агрегатов с химическим и минеральным составом руд и химическим составом породообразующих и рудных минералов. Установлено, что по структурным характеристикам пород возможно распознавать и прогнозировать химический состав сульфидов, содержание элементов платиновой группы в породе, морфологию сульфидных агрегатов. Показана возможность использования структурных характеристик пород для восстановления рудогенетических процессов.
Mechanochemical synthesis of unsymmetrical salens for the preparation of Co–salen complexes and their evaluation as catalysts for the synthesis of α-aryloxy alcohols via asymmetric phenolic kinetic resolution of terminal epoxides
Authors: Zuo Shengli , Zheng Shuxiang , Liu Jianjun , Zuo Ang
Published: October 2022

In this paper, we report the mechanochemical synthesis of unsymmetrical salens using grinding and ball milling technologies, respectively, both of which were afforded in good yield. The chelating effect of the unsymmetrical salens with zinc, copper, and cobalt was studied and the chiral Co–salen complex 2f was obtained in 98% yield. Hydrolytic kinetic resolution (HKR) of epichlorohydrin with water catalyzed by complex 2f (0.5 mol %) was explored and resulted in 98% ee, suggesting complex 2f could serve as an enantioselective catalyst for the asymmetric ring opening of terminal epoxides by phenols. A library of α-aryloxy alcohols 3 was thereafter synthesized in good yield and high ee using 2f via the phenolic KR of epichlorohydrin.
El jardín escolar un escenario pedagógico para la transmisión de saberes ancestrales y la siembra de plantas medicinales, Cumbal, Colombia
Authors: Cuaical Tapie Alba Nelly , Tapie Alpala Segundo Polibio
Published: October 2022

Este artículo hace parte de una investigación de maestría que pretendió generar aprendizajes a través de la práctica relacionada con la implementación del jardín escolar como escenario pedagógico, para el aprendizaje de saberes ancestrales asociados a las plantas medicinales, en el grado 6º de la Institución Educativa Divino Niño Jesús, Cumbal - Nariño. Se enmarcó en la investigación cualitativa basada en el paradigma sociocrítico con un diseño de investigación-acción, trabajando con 42 sujetos (estudiantes, docentes, padres de familia y sabedores). Entre las técnicas utilizadas figuran la observación, revisión documental, entrevista, encuesta y grupo focal, procesados y analizados cualitativamente para extraer las categorías, trianguladas para obtener el cruce dialéctico de la información. Los hallazgos sugieren la necesidad de un espacio como el huerto escolar para dar continuidad a la transmisión de los conocimientos ancestrales. Se concluyó con una propuesta educativa que evidencia que el jardín escolar es un escenario pedagógico propicio para el aprendizaje a través de la práctica adherida al conocimiento ancestral sobre el uso de las plantas medicinales que preserva la identidad cultural y garantiza la salud mental, física y espiritual de la población indígena
Incidencia de la pandemia en los índices de deserción escolar en el sistema educativo ecuatoriano
Authors: Borbor Gonzalez Shirley Denisse , Briones Cruz Johanna Gricelda , Torres Gómez Olga Teresa
Published: October 2022

El objetivo de la presente investigación fue establecer ciertas causas y consecuencias e identificar algunos datos estadísticos referentes a la deserción escolar que se dio a raíz de la pandemia ocasionada por el COVID-19, para efecto se empleó la investigación bibliográfica mediante la búsqueda de información actualizada y difundida en algunas revistas indexadas e información de bases de datos de entidades gubernamentales en las cuales se socializa el índice de deserción en los diferentes periodos educativos, mismos que han tenido un proceso de filtraje para determinar si son pertinentes con el tema de estudio.

La discusión está basada en la comparación de la información de las diferentes fuentes. La deserción escolar será abordada como problema social y se verificará de manera más latente con números y estadísticas fiables. Los principales resultadas denotan que más de 90 mil estudiantes abandonaron los procesos educativos durante la pandemia, porcentajes que agravaron la situación que se vivía en el Ecuador, puesto que ya se tenía una cantidad considerable de estudiantes que desertaron de la educación antes de la pandemia. No obstante, organizaciones como la UNICEF desarrollaron algunas acciones que ayudaron a evitar mayor cantidad de deserción y dar continuidad al aprendizaje de los niños, niñas y adolescentes, con actividades en concreto como la estrega de tablets y chips de llamada e internet, y también la creación del programa de televisión A-Prender la Tele.
STATUS OF COVID-19 IN THE WORST AFFECTED TWENTY COUNTRIES AND THE WORLD AT THE END OF 2020
Authors: Joshi Rushikesh G. , Rajput Kiransinh N. , Raval Vikram H. , Arya Prashant S. , Gohil Rinkal B. , Patani Aanal N. , Mahla Kalpesh L. , Pandya Jaimin B. , Panchal Rakeshkumar R.
Published: October 2022

The COVID-19 become ‘the first-worst pandemic’ of 21st century. The causative agent SARS-CoV-2 is a respiratory virus and is primarily transmitted between people through respiratory droplets. At the end of year 2020, COVID-19 has infected 84,532,824 people and carried out 1,845,597 deaths across the globe. Here, the epidemiology of COVID-19 in the worst affected twenty countries and the world up to December 2020 is reviewed. The distribution of COVID-19 across the globe observed about 78.70% of reported positive cases and 81.63% of the reported deaths in twenty countries viz. USA, India, Brazil, Russia, France, United Kingdom, Italy, Spain, Germany, Columbia, Argentina, Mexico Turkey, Poland, Iran, South Africa, Ukraine, Peru, Indonesia and Belgium. The highest COVID-19 cases were observed in the USA (20,640,214) with 6,235.66 cases per lakh people and this is far ahead than the world average of 2,910 cases per lakh people. The highest 351,590 number of deaths occurred in the USA but the highest deaths per lakh people is observed in Belgium (172.4) which is very higher than the world average (13.9). In the starting of year 2020, the case fatality rate was 2.17 % in January month, the highest 8.12 % in April and controlled to 1.78 % in December. The case fatality rate of Mexico (8.8 %) is very high compared to the world average (2.2 %). With the collective efforts of scientists and the governments, eight vaccines are in market and vaccination is in progress to combat the worst pandemic Covid-19.