bluuebunny/crossref_metadata_2025 huggingface dataset:
Psychological Impact of Presymptomatic X-Linked ALD Diagnosis and Surveillance: A Small Qualitative Study of Patient and Parent Experiences
Authors: Videbæk Cecilie S. , Grønborg Sabine W. , Lund Allan M. , Olesen Mette L.
Published: October 2024

X-linked adrenoleukodystrophy (ALD) is a rare metabolic disorder. Symptoms range from cerebral demyelination (cALD) to adrenal insufficiency and slowly progressive myeloneuropathy. cALD is fatal if not treated with hematopoietic cell transplantation in the early stages of the disease course. This can be achieved through cascade testing or newborn screening (NBS). Due to the lack of predictive measures of disease trajectory, patients are monitored with frequent MRI scans and hormone testing to ensure timely intervention. With this study, we wanted to explore how the diagnosis of ALD, before the development of cALD, and the follow-up program affected patients and their parents. Using semi-structured interviews, we interviewed seven parents of children with ALD aged 3–11 and four patients with ALD aged 18–25. Because NBS for ALD has not been implemented in Denmark, the patients were identified through either cascade testing or after having presented with adrenal insufficiency. We generated five themes: (I) ALD patients maintained mental resilience despite diagnosis and surveillance; (II) patients’ concerns matured with age and centered around situations that confronted them with their patient status; (III) parents of children with ALD had both short-term and long-term worries for their children’s health; (IV) parents took on a huge psychological burden; and (V) due to its rarity, the diagnosis of ALD evoked a sense of isolation and disease-related loneliness. Overall, we found a large discrepancy in the experiences reported by parents and patients. Despite the small sample size, we identified patterns that suggest that while the early diagnosis took a significant psychological toll on the parents, patients lived relatively carefree lives despite their ALD diagnosis.
Utilizing Insects as Bioindicators: An Approximation for Conservation in Urban Lentic Ecosystems in Central Chile
Authors: Rodríguez Sebastián , Huerta Amanda , Palma Álvaro , Vicencio Francisco , Araya Jaime E.
Published: October 2024

This study considered using insect families as bioindicators to establish the health status of an ecosystem of lentic bodies. The water quality in urban lentic bodies in the Metropolitan Region, Chile, was evaluated from aquatic insect family assemblages and physicochemical variables for conserving aquatic life. Evaluations were carried out in parallel at four sampling stations of three water bodies (Batuco Wetland, Carén Lagoon, and Chada Reservoir) in a 2–3-year series, spring (2015, 2017, and 2018) and fall (2016 and 2018), with three replicates. Families were randomly sampled and aquatic insects were identified; abundance and richness differences were compared with non-parametric tests. Physicochemical variables were measured using portable multiparametric and laboratory chemical analyses to determine the water quality. A Canonical Correspondence Analysis was applied for insect families and the physical–chemical variable. In order to categorize the health of these water bodies based on aquatic insect composition and abundance, the Family Biotic Index (FBI), British Biological Monitoring Work Party (BMWP), and Stream Invertebrate Grade Number—Average Level (SIGNAL), adapted for Chile by Figueroa et al. (2007), were calculated. The eudominant insect families were Corixidae and Chironomidae in Batuco, Chironomidae and Corixidae in Carén, and Corixidae in Chada. Baetidae was dominant in Carén and Chada. The water bodies were classified in descending order of water quality by Chilean physicochemical standards: Chada > Carén > Batuco. The TSS (total suspended solids), phosphorus, and electrical conductivity were strongly positively correlated and negatively associated with dissolved oxygen. The TSS level was the most significant influential factor. The BMWP value and the SIGNAL differed from the FBI, but the first was more restrictive, contributing to the conservation of these ecosystems. Based on the nitrogen and phosphorus levels in the water bodies, all of them were eutrophic. Given the ecosystem diversity and complexity, studies should delve deeper into wetlands to establish methods that contribute to determining water quality, using insect families as bioindicators and physicochemical variables.
Aedes (Georgecraigius) epactius from Zacatecas and Chihuahua Mexico: New Geographical Distribution and Altitude Records
Authors: Ramos-Lagunes Valeria H. , Laredo-Tiscareño S. Viridiana , González-Peña Rodolfo , Adame-Gallegos Jaime R. , Rodríguez-Alarcón Carlos A. , de Jesús de Luna-Santillana Erick , Hernández-Triana Luis M. , Velasco-Chino Lucia E. , Laredo-Tiscareño A. Gabriela , Garza-Hernández Javier A.
Published: October 2024

Adults and immatures of Aedes epactius were collected in July and December 2022 at sites of high elevation in the states of Chihuahua (2300 masl) and Zacatecas (2182 and 2595 masl), Mexico, respectively. Mosquitoes were identified morphologically and sequenced for a DNA barcode of the cytochrome c oxidase I (COX1). This is the first distributional record of Ae. epactius in Zacatecas and provides evidence of the highest altitude in the Americas, including Mexico. The geographical distribution of Ae. epactius in Mexico was reviewed, and the COX1 analysis, using phylogenetic Bayesian analysis to confirm species identification, was performed.
Comparison of Left Ventricular Global Longitudinal Strain and Left Ventricular Ejection Fraction in Acute Respiratory Failure Patients Requiring Invasive Mechanical Ventilation
Authors: Bashir Zubair , Ataklte Feven , Wang Shuyuan , Chen Edward W. , Kadiyala Vishnu , Sherrod Charles F. , Has Phinnara , Song Christopher , Ventetuolo Corey E. , Simmons James , Haines Philip
Published: October 2024

Left ventricular (LV) dysfunction is associated with poor clinical outcomes in acute respiratory failure (ARF). This study evaluates the efficacy of LV strain in detecting LV dysfunction in ARF patients requiring invasive mechanical ventilation (IMV) compared to conventionally measured left ventricular ejection fraction (LVEF). ARF patients requiring IMV who had echocardiography performed during MICU admission were included. LV global longitudinal strain (LVGLS) and LVEF were measured retrospectively using speckle tracking (STE) and traditional transthoracic echocardiography (TTE), respectively, by investigators blinded to the status of IMV and clinical data. The cohort was divided into three groups: TTE during IMV (TTE-IMV), before IMV (TTE-bIMV), and after IMV (TTE-aIMV). Multivariable regression models, adjusted for illness severity score, chronic cardiac disease, acute respiratory failure etiology, body mass index, chronic obstructive pulmonary disease, and obstructive sleep apnea, evaluated associations between LV function parameters and the presence of IMV. Among 376 patients, TTE-IMV, TTE-bIMV, and TTE-aIMV groups constituted 223, 68, and 85 patients, respectively. The median age was 65 years (IQR: 56–74), with 53.2% male participants. Adjusted models showed significantly higher LVGLS in groups not on IMV at the time of TTE (TTE-bIMV: β = 4.19, 95% CI 2.31 to 6.08, p < 0.001; TTE-aIMV: β = 3.79, 95% CI 2.03 to 5.55, p < 0.001), while no significant differences in LVEF were observed across groups. In a subgroup analysis of patients with LVEF ≥55%, the significant difference in LVGLS among the groups remained (TTE-bIMV: β = 4.18, 95% CI 2.22 to 6.15, p < 0.001; TTE-aIMV: β = 3.45, 95% CI 1.50 to 5.40, p < 0.001), but was no longer present in those with LVEF < 55%. This suggests an association between IMV and lower LVGLS in ARF patients requiring IMV, indicating that LVGLS may be a more sensitive marker for detecting subclinical LV dysfunction compared to LVEF in this population. Future studies should track and assess serial echocardiography data in the same cohort of patients pre-, during, and post-IMV in order to validate these findings and prognosticate STE-detected LV dysfunction in ARF patients requiring IMV.
Clinical Efficacy and Safety of Misoprostol During Abdominal Myomectomy: An Updated Systematic Review and Meta-Analysis of 16 Randomized Controlled Trials
Authors: Abu-Zaid Ahmed , Al Baalharith Maha , Alsabban Mohannad , Alomar Osama , Abuzaid Mohammed , Alsehaimi Saud Owaimer , Albelwi Hedaya , Alqarni Saad M. S. , Alqahtani Manal Ali , Jamjoom Mohammed Ziad , Baradwan Saeed , Sabban Hussein , Himayda Samah , Albouq Bayan , Badghish Ehab , Baradwan Afnan , Sindi Raghad , Al-Badawi Ismail A.
Published: October 2024

Objective: This study offered an updated meta-analysis of randomized controlled trials (RCTs) that assessed preoperative misoprostol compared to control (matched placebos or no treatment) during abdominal myomectomies. Methods: Six databases underwent screening until 7 April 2024. The risk of bias was assessed using the Cochrane Collaboration tool. The results were presented as mean differences (MDs) or risk ratios (RRs) along with 95% confidence intervals (CIs) using the random-effects model. Results: Sixteen RCTs were analyzed, involving 975 women. The overall quality of the studies was rated as “low” or had “some concerns” of bias in seven and eight RCTs, respectively; one RCT had an overall “high” risk of bias. For primary endpoints, the misoprostol intervention had significantly lower mean intraoperative blood loss (n = 15, MD = −180.2 mL, 95% CI [−224.04, −136.35], p < 0.001), mean hemoglobin drop (n = 13, MD = −0.58 g/dl, 95% CI [−0.82, −0.35], p < 0.001), and rate of perioperative blood transfusion (n = 13, RR = 0.43, 95% CI [0.29, 0.63], p < 0.001) compared to the control intervention. For secondary endpoints, the misoprostol intervention had significantly lower mean hematocrit drop (MD = 2.15, 95% CI −3.34, −0.96], p < 0.001), mean operative time (MD = −12.95 min, 95% CI [−19.89, −6.01], p < 0.001), and mean hospital stay (MD = −0.14 days, 95% CI [−0.25, −0.02], p = 0.02) compared to the control intervention. Nonetheless, no significant change was indicated between both interventions regarding the rate of postoperative fever. Conclusions: During abdominal myomectomy, the administration of preoperative misoprostol was generally safe and yielded statistically significant reductions in intraoperative blood loss, hemoglobin drop, and perioperative blood transfusion.
The Validity of a Smartphone-Based Method for Acquiring 3D Images of the Face
Authors: Papadopoulou Alexandra K. , Di Santo Francesca , Antonarakis Gregory S. , Ghislanzoni Luis Huanca
Published: October 2024

Objectives. To evaluate the accuracy and reproducibility of measurements obtained using the Bellus3D Face Application on a mobile smartphone by comparing them to direct measurements on pre-marked and blank face scans. Materials and Methods. Twenty-five healthy young adults (six males and nineteen females; age range 20–30 years) were included in this prospective cross-sectional study, with the only exclusion criterion being the presence of significant facial hair interfering with the placement and visualization of landmarks. Image acquisitions were performed using an iPhone XR with the Bellus3D FaceApp face scanning application, an iOS application for smartphones. Ten single midfacial and five paired bilateral landmarks were defined and marked. Two face scans were performed on each patient, both on blank and marked faces, and distances were measured directly with calipers and digitally. Results. The random error values were 1.0 mm and 0.4 mm for the manual point placement and measurements and virtual point placement on blank faces, respectively. The two methods used (the direct method and acquisition on faces with landmarks) demonstrate relatively similar reliability (ICC > 0.8); however, a paired t-test showed that the differences between several measurements were statistically significant (p < 0.05). Regardless of the method used, there was a systematic error for various values that included the nose and mouth (p < 0.05). The measurements demonstrating the most significant differences between the methods were those that included the tip of the nose, with the mean differences being −4.4–3.3 mm. The measurements of the distances that estimate face “depth” showed the greatest consistency irrespective of the tested method (p > 0.05 and ICC > 0.8). Conclusions. The use of the Bellus3D FaceApp is precise and reproducible for certain areas of the face, but digital reconstruction errors prohibit, for the time being, the use of this technology in everyday clinical practice. The noted discrepancies were consistent and more prevalent for specific areas such as the tip of the nose. Further investigations are required to determine other sources of error and for other smartphone-based applications released for 3D face image acquisitions.
Imaging in Large Vessel Vasculitis—A Narrative Review
Authors: Popescu Ioana , Pintican Roxana , Cocarla Luminita , Burger Benjamin , Sandu Irina , Popa George , Dadarlat Alexandra , Rancea Raluca , Oprea Alexandru , Goicea Alexandru , Damian Laura , Manea Alexandru , Mateas Ruben , Manole Simona
Published: October 2024

Vasculitis refers to a group of rare conditions characterized by the inflammation of blood vessels, affecting multiple systems. It presents a diagnostic and therapeutic challenge due to its broad clinical manifestations. Vasculitis is classified based on the size of the affected vessels: small, medium, large, or variable-sized. Large vessel vasculitis (LVV), particularly giant cell arteritis (GCA) and Takayasu arteritis (TAK), has garnered attention due to its significant morbidity and mortality. Both conditions involve immune-mediated inflammation of the vascular wall, despite differing in epidemiology and presentation. Early identification is crucial to prevent complications like organ ischemia and hemorrhage. Diagnostic accuracy can be hampered by false negative results, making comprehensive investigation essential. Vascular imaging, including computed tomography angiography (CTA), ultrasound (US), magnetic resonance imaging (MRI), and positron emission tomography-computed tomography (PET-CT), is key in diagnosing vasculitis, revealing vessel wall thickening and other suggestive features. This article reviews typical and atypical CT and CTA findings in LVV, discusses imaging modalities, and highlights their role in therapeutic management and prognosis. It emphasizes the importance of a multidisciplinary approach and the critical role of radiologists in improving patient outcomes in LVV.
Heart Rate Recovery Index and Improved Diastolic Dyssynchrony in Fusion Pacing Cardiac Resynchronization Therapy
Authors: Gurgu Andra , Luca Constantin-Tudor , Vacarescu Cristina , Gaiță Dan , Crișan Simina , Faur-Grigori Adelina-Andreea , Cozlac Alina-Ramona , Tudoran Cristina , Margan Mădălin-Marius , Cozma Dragos
Published: October 2024

Background: Restoring electrical synchrony with cardiac resynchronization therapy (CRT) reverses the heart failure phenotype developed by left-ventricular (LV) dyssynchrony. This study aimed to identify new predictors of response to LV-only fusion pacing CRT. Methods: A select group of patients with CRT-P indications received a right atrium (RA)/LV DDD pacing system. LV dyssynchrony was assessed via offline TDI timing focusing on the temporal difference between peak septal (E″T) and lateral wall (A“T) motion. CRT effectiveness was evaluated at each follow-up, involving the heart rate recovery index (HRRI) parameter (acceleration/deceleration time) derived from exercise testing along with the echocardiographic parameters. Patients were classified into super-responders (SR), responders (R), and non-responders (NR). Results: Baseline initial characteristics: 62 patients (35 male) aged 62 ± 11 y.o. with non-ischemic dilated cardiomyopathy (DCM). Ejection fraction (EF) 27 ± 5.2%; QRS 164 ± 18 ms; 29% had type III diastolic dysfunction (DD), 63% type II DD, and 8% type I DD. Average follow-up was 45 ± 19 months: 34% of patients were SR, 61% R, and 5% NR. The E″T decreased from 90 ± 20 ms to 25 ± 10 ms in SR, with a shorter deceleration time (DT) during exercise test compared to NR (109 ± 68 ms vs. 330 ± 30 ms; p < 0.0001). The responders present a higher HRRI (2.87 ± 1.47 vs. 0.98 ± 0.08; p = 0.03) compared to NR and a significantly decrease in E“T and A“T from 76 ± 13 ms to 51 ± 11 ms (p < 0.0001). Prolonged DT was associated with an accentuated LV dyssynchrony and nonoptimal response to CRT. Conclusions: The study identified new parameters for assessing responsiveness to LV-only fusion pacing CRT, which could improve candidate selection and CRT implementation.
Comparison of the Determinants of the “Chronic Obstructive Pulmonary Disease Assessment Test” (CAT) and the “Asthma Control Test” (ACT) in Patients with Asthma–COPD Overlap
Authors: Aljama Cristina , Granados Galo , Callejas-González Francisco Javier , Martínez-Rivera Carlos , Pallarés-Sanmartín Abel , Rodríguez-Pons Laura , Cabrera-César Eva , Márquez-Martín Eduardo , Boldova-Loscertales Ana , Naval-Sendra Elsa , Abascal-Bolado Beatriz , Cabrera-López Carlos , Miravitlles Marc , Esquinas Cristina , Barrecheguren Miriam
Published: October 2024

Objective: The objective of this study was to investigate which of two short questionnaires, the Asthma Control Test (ACT) or the COPD Assessment Test (CAT), correlates better with severity variables and whether they share similar determinants in patients with asthma–COPD overlap. Method: This observational, cross-sectional, multicentric study included smokers and former smokers of more than 10 pack-years, with non-fully reversible airflow obstruction and either a concomitant diagnosis of asthma or signs of type 2 inflammation, from 15 centres in Spain. Results: A total of 157 patients were included, 109 (69.4%) were men, the mean age was 63.3 (SD: 9) years and the mean FEV1 (%) was 59.7% (SD: 20.5%). The mean CAT score was 14.5 (SD: 8.7), and the mean ACT score was 17.9 (SD: 5.2). Both scores showed good correlations (r = 0.717; p < 0.001). In the multivariate analysis, the Hospital Anxiety and Depression Scale and mMRC dyspnoea scores were independently and significantly associated with both the CAT and ACT scores; however, age was only significantly associated with the CAT, and the EQ-5D scores and the number of exacerbations in the previous year were only significantly associated with the ACT scores. The ACT had a slightly better predictive value for exacerbations than the CAT (AUC = 0.70 (95% CI: 0.62 to 0.79 vs. 0.65 (95% CI: 0.56 to 0.74))). Conclusions: There is a good correlation between ACT and CAT scores in patients with ACO. However, severe patients scored worse on the CAT than the ACT. Anxiety, depression and dyspnoea were significantly associated with both the CAT and ACT scores. The ACT was a slightly better predictor of exacerbations than the CAT in this population.
Optimization of the Properties of Microsilica-Based Composite Briquettes Depending on Their Granulometry
Authors: Baisanov Alibek , Vorobkalo Nina , Shabanov Yerbol , Zobnin Nikolay , Baisanova Aidana , Sharieva Symbat , Akuov Askhat , Samuratov Yerulan , Ibrakhimova Zhanna , Zhumagaliev Temirlan
Published: October 2024

This paper presents the results of optimizing the physicochemical properties of microsilica-based composite briquettes for metallurgical-grade silicon production. Microsilica, a waste product of silicon production, contains a sufficiently high amount of silicon dioxide (96–97%). This fact makes microsilica a promising composite material for metallurgical processing. However, its granulometric composition limits its direct use. The method of briquetting on an industrial briquetting press was used. The influence of the granulometric composition of the composite mixture on the heat tolerance and reactivity of the finished briquettes was studied. The methods of obtaining and testing the briquettes, their composition, and the briquetting and drying process were described. The obtained briquettes were tested for the smelting of metallurgical silicon. The silicon recovery rate in the metal with the standard charge was 71%, while the recovery rate with the briquetted monocharge was 85%. The results of silicon smelting from the briquettes demonstrated the high quality of the obtained metal, corresponding to the standards of metallurgical-grade silicon. The implementation of these technologies improves the quality of the finished product and addresses environmental issues related to the disposal of microsilica, reducing its accumulation and minimizing its impact on the environment.
Estimate Anaerobic Work Capacity and Critical Power with Constant-Power All-Out Test
Authors: Tsai Ming-Chang , Thomas Scott , Klimstra Marc
Published: October 2024

Background: The critical power model (CPM) is used extensively in sports to characterize fitness by estimating anaerobic work capacity (W’) and critical power (CP). Traditionally, estimates of CP and W’ require repeated, time-consuming tests. Alternatively, a 3 min all-out test yields good estimates of W’ and CP. However, adoption of the 3 min protocol for regular fitness monitoring is deterred by the mentally/physically strenuous nature of the test. Objective: We propose to examine an alternative single-session testing protocol that can accurately estimate critical power model parameters. Methods: Twenty-eight healthy competitive athletes (cyclists or triathletes) (mean ± SD: age: 38.5 ± 10.4 years, height: 177.9 ± 8.6 cm, mass: 73.4 ± 9.9 kg) participated in 5 sessions on a Lode cycle ergometer in isokinetic mode within a 2-week period. A 3 min all-out test (3MT) was conducted on the first visit to determine CPM parameters from which power outputs for 4 subsequent constant-power plus all-out tests (CPT) were selected to result in exhaustion in 1–10 min. The subjects were to maintain the prescribed power output as consistently as possible at their preferred race cadence. Once the power output could no longer be maintained for more than 10 s, the subjects were instructed to produce an all-out effort. Tests were terminated after power output fell to an asymptote which was sustained for 2 min. Results: The CPM parameters for all of the CPT durations were compared to the traditional CP protocol (significant parameter differences were identified for all CPT durations) and the 3MT (only CPT durations > 3 min were different [3–6 min test, p < 0.01; >6 min test, p < 0.01]). CPT does not estimate traditional CP and W’ parameters well. However, the CPT with a duration < 3 min accurately estimates both parameters of a 3MT. Conclusion: Therefore, CPT has the capacity to serve as an alternative tool to assess CP parameters.
Multi-Head Attention Refiner for Multi-View 3D Reconstruction
Authors: Lee Kyunghee , Cho Ihjoon , Yang Boseung , Park Unsang
Published: October 2024

Traditional 3D reconstruction models have consistently faced the challenge of balancing high recall of object edges with maintaining a high precision. In this paper, we introduce a post-processing method, the Multi-Head Attention Refiner (MA-R), designed to address this issue by integrating a multi-head attention mechanism into the U-Net style refiner module. Our method demonstrates improved capability in capturing intricate image details, leading to significant enhancements in boundary predictions and recall rates. In our experiments, the proposed approach notably improves the reconstruction performance of Pix2Vox++ when multiple images are used as the input. Specifically, with 20-view images, our method achieves an IoU score of 0.730, a 1.1% improvement over the 0.719 of Pix2Vox++, and a 2.1% improvement in F-Score, achieving 0.483 compared to 0.462 of Pix2Vox++. These results underscore the robustness of our approach in enhancing both precision and recall in 3D reconstruction tasks involving multiple views.
Development of AI-Based Multisensory System for Monitoring Quay Wall Events
Authors: Shin Junsik , Park Junyoung , Won Jongbin , Park Jongwoong , Min Jiyoung
Published: October 2024

Structural monitoring of quay walls, where various events occur due to unexpected high waves, vessels, and heavy equipment, is essential. However, real-time events cannot be constantly monitored by on-site personnel. To resolve the aforementioned issues, this study proposes an innovative AI-powered, cloud-based wireless sensor system that incorporates a high-sensitivity accelerometer with an ultra-low noise level of 0.003 mg, designed to monitor the low response amplitude of massive quay walls. The sensor can be activated by a scheduled trigger or a long-rangefinder. Vessel detection is performed utilizing the AI-based object detection method, Faster R-CNN, which employs ResNet as the backbone network. The detected anchor box’s position and dimensions are subsequently processed to confirm the presence of a berthing vessel. The collected data are then transmitted wirelessly to a proposed cloud server through LTE communication in real-time. The developed system was installed on a caisson-type quay wall in Korea, where acceleration, tilt, temperature, and camera image data were analyzed to assess its performance for real-time event monitoring. The results demonstrated that the safety of quay walls can be automatically managed by monitoring events during berthing and mooring with the proposed system.
Effects of Elevated Seawater Temperatures on Cellular Immune Function in the Top Shell, Turbo sazae
Authors: Yang Hyun-Sung , Park Areumi , Park Heung-Sik , Kang Do-Hyung , Hong Hyun-Ki
Published: October 2024

The top shell, Turbo sazae, occurs commonly in the shallow rocky subtidal area of Jeju Island off the south coast of Korea, and it is one of the most valuable gastropod resources supporting the local shellfish industry. T. sazae landings in Jeju have declined dramatically in recent years, although the factors involved in this decline are yet to be identified. Recent studies also have reported that T. sazae is expanding its distribution range to the east coast of Korea, possibly due to the increasing seawater temperature. In this study, we investigated the hemocyte responses of T. sazae to elevated seawater temperatures in order to gain a better understanding of its immunological response to higher water temperatures. In this experiment, we exposed top shells to a gradual increase in seawater temperature, ranging from 22 °C to 30 °C, over a span of 9 days. We employed flow cytometry to assess various cellular immune responses, including hemocyte viability, phagocytosis capacity, and the production of reactive oxygen species (ROS) in T. sazae. The results showed that top shells exposed to elevated seawater temperature exhibited a significant decrease in phagocytosis capacity and an increase in ROS production after 3 days of the experiment. These findings indicate that an elevated seawater temperature imposes a stressful condition on T. sazae, characterized by reduced phagocytosis capacity and increased oxidative stress.
Application of Advanced Algorithms in Port State Control for Offshore Vessels Using a Classification Tree and Multi-Criteria Decision-Making
Authors: Boko Zlatko , Skoko Ivica , Sanchez-Varela Zaloa , Pincetic Tony
Published: October 2024

This article examines the methods and application of classification trees and multi-criteria decision-making in the process of holding offshore vessels in port (Port State Control—PSC). This work aims to improve the efficiency and precision of the control processes in the detention of offshore vessels by using advanced analytical methods. Methodologically, a classification decision tree was used to identify the most important risk factors, enabling a faster and more accurate assessment of the possibility of detaining offshore vessels in port. Multi-criteria decision-making (MCDM) also enabled the simultaneous assessment of multiple factors, ensuring a balanced, robust, accurate, and objective approach. The research results show that the integration of these methods into the PSC process can significantly increase the safety of shipping and reduce the operating costs of offshore vessels. The application of these analytical tools can lead to a more systematic and transparent inspection process. This paper suggests further research and training of inspectors in the use of these techniques to maximize their applicability and effectiveness. Finally, this paper emphasizes the potential of classification trees and MCDM for safer and more efficient maritime transport by improving PSC procedures.
Diversity and Anti-Infectious Components of Cultivable Rhizosphere Fungi Derived from Three Species of Astragalus Plants in Northwestern Yunnan, China
Authors: Zhou Guo-Jun , Xiong Wei-Jia , Xu Wei , Dou Zheng-Rong , Liu Bo-Chao , Li Xue-Li , Du Hao , Li Hai-Feng , Zhang Yong-Zeng , Jiang Bei , Wang Kai-Ling
Published: October 2024

Astragalus, a group of legume plants, has a pronounced rhizosphere effect. Many species of Astragalus with limited resource reserves are distributed in the high-altitude area of northern Yunnan, China. Although some of these plants have high medicinal value, the recognition of them is still at a low level. The aim of this research is to explore the species diversity of cultivable rhizofungi derived from Astragalus acaulis, A. forrestii and A. ernestii growing in a special high–cold environment of northwest Yunnan and discover anti-infective components from these fungi. A total of 93 fungal strains belonging to 38 species in 18 genera were isolated and identified. Antibacterial and antimalarial screening yielded 10 target strains. Among them, the ethyl acetate crude extract of the fermented substrate of the rhizofungus Aspergillus calidoustus AA12 derived from the plant A. acaulis showed broad-spectrum antibacterial activity and the best antimalarial activity. Further chemical investigation led to the first discovery of seven compounds from the species A. calidoustus, including sesterterpine 6-epi-ophiobolin G; three sesquiterpenes, penicisochroman A, pergillin and 7-methyl-2-(1-methylethylethlidene)-furo [3,2-H]isoquinoline-3-one; and three polyketides, trypacidin, 1,2-seco-trypacidin and questin. Among them, the compound 6-epi-ophiobolin G exhibited moderate to strong antibacterial activity against six Gram-positive pathogens with the minimum inhibitory concentration (MIC) ranging from 25 to 6.25 μg/mL and a prominent inhibitory effect on the biofilm of Streptococcus agalactiae at an MIC value of 3.125 μg/mL. This compound also displayed potent antimalarial activity against Plasmodium falciparum strains 3D7 and chloroquine-resistant Dd2 at the half-maximal inhibitory concentration (IC50) values of 3.319 and 4.340 µmol/L at 72 h, respectively. This study contributed to our understanding of the cultivable rhizofungi from characteristic Astragalus plants in special high–cold environments and further increased the library of fungi available for natural anti-infectious product screening.
New Polyketide Congeners with Antibacterial Activities from an Endophytic Fungus Stemphylium globuliferum 17035 (China General Microbiological Culture Collection Center No. 40666)
Authors: Li Yingying , Zhu Guoliang , Wang Jing , Yu Junjie , Ye Ke , Xing Cuiping , Ren Biao , Zhu Bin , Chen Simin , Lai Lijun , Li Yue , Hsiang Tom , Zhang Lixin , Liu Xueting , Zhang Jingyu
Published: October 2024

Four new polyketides, heterocornol Y (1), stemphyindan (2), pestalospirane C (3), and stemphyspyrane (4), along with five known ones (5–9) were isolated from the endophytic fungus Stemphylium globuliferum 17035 (SG17035) based on the One Strain Many Compounds (OSMAC) strategy allied with an LC-MS approach. These structures were elucidated through extensive spectroscopic analyses, single-crystal X-ray diffraction, and 13C NMR-DP4 analysis. Pestalospirane C (3) and stemphyspyrane (4) featured unprecedented spiroketal skeletons. In addition, the putative biosynthetic logic for compounds 1–4 was proposed. Antibacterial and cytotoxic activities of compounds 1–9 were evaluated. Stemphyspyrane (4) displayed promising antibacterial activity against different pathogens, especially against Staphylococcus aureus, Porphyromonas gingivalis, and methicillin-resistant Staphylococcus aureus (MRSA) with MIC values of 3.125 μM, 6.25 μM, and 12.5 μM, respectively. It is promising as an antibacterial agent for further optimization.
Assessing the Impact of the Pandemic on Treatment Outcomes for Cardiac Arrest Patients Utilizing Mechanical CPR: A Nationwide Population-Based Observational Study in South Korea
Authors: Kim Jae Hwan , Oh Young Taeck , Ahn Chiwon
Published: October 2024

Introduction: Cardiopulmonary resuscitation with mechanical devices (MCPR) was developed to provide high-quality cardiopulmonary resuscitation (CPR) for patients with cardiac arrest. However, the effect of this procedure on treatment outcomes remains controversial. Nevertheless, during the coronavirus disease-19 (COVID-19) pandemic, in-hospital MCPR gained attention, owing to its advantages such as saving medical staff and preventing infection. This study compared the treatment outcomes of in-hospital MCPR and manual CPR for out-of-hospital cardiac arrest (OHCA) patients during the COVID-19 pandemic. Materials and Methods: This retrospective nationwide population-based study was conducted in South Korea. Data were collected from the Out-of-Hospital Cardiac Arrest surveillance database managed by the Korea Disease Control and Prevention Agency. We included adult OHCA patients transported by emergency medical services from 2016 to 2021. The study compared outcomes during the COVID-19 pandemic years (2020–2021) with the preceding non-pandemic years (2018–2019). The primary outcome was survival to hospital discharge, and the secondary outcomes were good neurological outcome and sustained return of spontaneous circulation (ROSC). Results: The entire study included 72,050 patients with OHCA and, in the multivariable analyses, MCPR was associated with lower survival rates compared to manual CPR (AOR 0.63; 95% CI 0.51–0.77; p < 0.001). Interestingly, during the COVID-19 pandemic, while MCPR use increased, the survival rate did not differ significantly between the MCPR and manual-CPR groups. Conclusion: Our study findings suggest that while MCPR may offer potential benefits, such as decreased infection risk for healthcare workers, it did not demonstrate superior outcomes compared to manual CPR in our study population.
Market Volatility vs. Economic Growth: The Role of Cognitive Bias
Authors: Parashar Neha , Sharma Rahul , Sandhya S. , Joshi Apoorva
Published: October 2024

This study aims to investigate the interaction between market volatility, economic growth, and cognitive biases over the period from April 2006 to March 2024. Market volatility and economic growth are critical indicators that influence economic stability and investment behavior. Financial market volatility, defined by abrupt and erratic changes in asset values, can have a big impact on the expansion and stability of the economy. According to conventional economic theory, there should be an inverse relationship between market volatility and economic growth since high volatility can discourage investment and erode trust. Market participants’ cognitive biases are a major aspect that complicates this connection. Due to our innate susceptibility to cognitive biases, including herd mentality, overconfidence, and loss aversion, humans can make poor decisions and increase market volatility. These prejudices frequently cause investors to behave erratically and irrationally, departing from reasonable expectations and causing inefficiencies in the market. Cognitive biases have the capacity to sustain feedback loops, which heighten market turbulence and may hinder economic expansion. Similarly, cognitive biases have the potential to cause investors to misread economic indicators or ignore important details, which would increase volatility. This study uses the generalized autoregressive conditional heteroskedasticity (GARCH) model on GDP growth data from the US, the UK, and India, alongside S&P 500, FTSE 100, and NIFTY 50 data sourced from Bloomberg, to examine evidence of these biases. The results show evidence of the predictive nature of market fluctuations on economic performance across the markets and highlight the substantial effects of cognitive biases on market volatility, disregarding economic fundamentals and growth, emphasizing the necessity of considering psychological factors in financial market analyses and developing strategies to mitigate their adverse effects.
Is the Foot a Prosodic Domain in European Portuguese?
Authors: Vigário Marina , Martínez-Paricio Violeta
Published: October 2024

It is widely accepted that languages organize speech material into prosodic domains, which are hierarchically arranged. However, it is still a matter of debate whether this prosodic hierarchy is composed of a small number of universal categories, or whether these prosodic categories are language-particular and emergent. In this article, we concentrate on one of these categories, the foot, and we investigate its role in European Portuguese (EP). Whereas research on EP has shown that other prosodic domains commonly found crosslinguistically are active in the language, it seems that EP may lack this prosodic constituent. Therefore, the goal of this article is to systematically investigate the role of the foot in a number of areas within EP grammar. In our study, we defend some new approaches to several long-standing issues in EP phonology and we conclude that many facts of the language can be, in fact, better understood resorting to the foot domain. Namely, the distribution of stress in the most frequent morphological classes (thematic non-verbs and present tense verbs), -inh-/-zinh- diminutive formation, the domain for regular vowel reduction, obligatory glide formation, the stress window, and poetic rhyme seem to benefit from a metrically-governed account. By contrast, other facts, such as vowel lowering, word clipping, minimal words, secondary stress, and schwa deletion are shown not to be conditioned by the foot in EP. Importantly, the evidence we found for metrical structure only cues the prominent foot of the word, suggesting that pretonic material may not be footed. All in all, in addition to shedding light on facts previously poorly understood, and exposing some noteworthy specificities of EP in the realm of Romance languages and other varieties of Portuguese, we draw implications for the universal characterization of the prosodic hierarchy and its acquisition.
Weight Gain in HIV Adults Receiving Antiretroviral Treatment: Current Knowledge and Future Perspectives
Authors: Markakis Konstantinos , Tsachouridou Olga , Georgianou Eleni , Pilalas Dimitrios , Nanoudis Sideris , Metallidis Symeon
Published: October 2024

Body weight is impacted by several individual host and environmental factors. In a person living with HIV (PLWH), weight is also influenced by the disease stage. Wasting syndrome is derived from disease progression, and it can be reversed by the effective use of highly active antiretroviral therapy (HAART). Body weight alterations have been studied and compared in several clinical ART trials, and they differ according to antiviral regimens. The newer integrase strand transfer inhibitors (INSTIs), such as bictegravir and dolutegravir, especially when co-administered with tenofovir alafenamide fumarate (TAF), seem to lead to greater weight increases compared to regimens that include tenofovir disoproxil fumarate (TDF), which seem to have an attenuating effect on weight gain. Nevertheless, despite the established association between INSTI and TAF and the negative impact on weight, more recent data suggest a more cautious approach when HAART treatment decisions are taken. In this manuscript, we review weight changes among PLWH receiving HAART and the relevant underlying pathogenic mechanisms described in recent literature. We try to provide a more critical appraisal of the available data and to underline the challenges in assessing the role of HAART in weight changes in both ART initiation and setting switching.
Abrasive Wear Characteristics of 30MnB5 Steel for High-Speed Plough Tip of Agricultural Machinery in Southern Xinjiang Region
Authors: Han Xiaorui , Yao Qiang , Li Mingjian , Guo Zhanhong , Fan Pengwei , Zhou Ling , Zhang Youqiang
Published: October 2024

The high-speed plough tip is the core soil-touching component in southern Xinjiang field cultivation, but the interaction of the plough tip with the soil results in severe wear of the tip. The friction behaviour of sand and soil on plough tips was investigated with a homemade rotary abrasive wear tester in a one-factor multilevel test with three parameters: moisture content, velocity/rotational speed and friction distance. The objective was to study the friction behaviour of the sand soil and plough tip and analyse and characterise the wear amount, wear thickness and compressive stress distribution, three-dimensional wear morphology and microscopic wear morphology of the plough tips. The results show that with increasing speed, the wear amount changes more gently; with increasing soil water content, the soil adhesion force and lubricating water film increase so that the wear amount follows a second-order parabolic law; and with increasing friction distance, the wear amount gradually increases, and the wear rate also shows an upward trend when the plough tip is in the abrasive wear stage. The tip makes contact with the firmer soil with higher surface compressive stresses, causing the most wear. As the friction distance increases, sand particles become embedded in the contact surfaces, creating a groove effect along with spalling pits caused by fatigue wear. During the whole wear period, the groove effect is always accompanied by spalling pits appearing repeatedly. The analysis of the wear micromorphology of the plough tip shows that the number of flaking pits gradually decreases in the direction of soil movement, and the form of damage changes from impact wear to plough groove scratches. Abrasive wear interacts with corrosive wear to exacerbate plough tip wear.
New Allyl Derivative of Curcumin: Synthesis and Crystal Structure of (1E,6E)-4-allyl-1,7-bis(4′-allyloxy-3′-methoxyphenyl)hepta-1,6-diene-3,5-dione
Authors: Druzina Anna A. , Zhidkova Olga B. , Anufriev Sergey A. , Dubasova Ekaterina V. , Ananyev Ivan V. , Banerjee Samya , Sivaev Igor B. , Bregadze Vladimir I.
Published: October 2024

A new allyl derivative of curcumin containing three allyl groups (1E,6E)-4-allyl-1,7-bis(4′-allyloxy-3′-methoxyphenyl)hepta-1,6-diene-3,5-dione was synthesized by the reaction of curcumin with the excess of allyl bromide in the presence of K2CO3 in acetone under reflux. The triple-allylated curcumin was characterized by 1H and 13C-NMR spectroscopy and single-crystal X-ray diffraction analysis.
The Effect of Fractional Composition on the Graphite Matrices’ Porosity
Authors: Gritskevich Mariya D. , Gracheva Alexandra V. , Filippova Mariya S. , Konstantinov Maxim S. , Aitbaev Rashit R. , Morozov Nikolai S. , Chebotarev Sergei N. , Avdeev Viktor V.
Published: October 2024

Synthetic graphite of complex fractional composition was mixed with phenolic resin as a binder and pore-forming component. The mixtures were pressed and subsequently heat-treated to obtain porous matrices. The structural transformations of phenolic resin by heating up to 900 °C in oxygen and inert gas media were studied and the patterns of amorphization of fixed carbon formed on the walls of the pore system during carbonization were investigated. We found regularities in the changes in matrix volume density in the function of the open porosity and the average pore diameter. It is shown that, in order to obtain graphitized carbon matrices with a density of 1 g/cm3 and an open porosity of at least 50%, it is necessary to introduce no more than 20% of phenolic resin into the molding powder with an equal content of 60, 100 and 250 μm graphite fractions. This allows for high intensity and completeness of bulk silicon infiltration.
Impact of DBD Plasma Jet Treatment on the Enamel Surface of Primary Teeth
Authors: Kwiatkowski Michał , Pawłat Joanna , Starek-Wójcicka Agnieszka , Krajewska Marta , Terebun Piotr , Zarzeczny Dawid , Machoy Monika , Mazur-Lesz Agnieszka , Matsuyama Narumol , Murakami Tomoyuki , Hayashi Nobuya , Grządka Elżbieta
Published: October 2024

The impact of cold atmospheric plasma (CAP) treatment on the enamel of twelve primary teeth (incisors, canines, and molars) collected from six children was examined in order to evaluate the possibility of using the CAP technique in dental applications. A radio-frequency dielectric barrier discharge (DBD) plasma jet operating at a voltage of 3.25 kV using a mixture of helium and oxygen as the working gas was used for the generation of plasma as part of the electro-technological method for the treatment of biological material. The plasma exposure time for the primary teeth was 5, 10, and 20 min. The properties of tooth enamel (color, contact angles, surface roughness, surface topography, elemental composition) were examined before (control) and after the plasma treatment. As shown by the results, the plasma treatment time is a key parameter that can induce desired features, such as whitening or improved wettability. However, with prolonged plasma treatment (20 min), the enamel surface may be permanently damaged. The cold-plasma-treated samples were characterized by a higher value of the brightness L* parameter and thus a lighter color, compared to the CAP-untreated teeth. It was also evidenced that the plasma treatment increased the hydrophilicity of tooth surfaces, and the contact angles effectively decreased with the time of the CAP treatment. The tooth surface also became much more heterogeneous and rough with much greater amplitudes in heights. The surface of the primary teeth after the CAP treatment lost its homogeneity, as evidenced by the SEM micrographs. The analysis of the elemental composition revealed only minor changes after the plasma process, which may suggest that the observed morphological changes in the enamel surface are mainly physical and are not a consequence of chemical reactions between the enamel and the reactive components of the cold plasma. Plasma treatment of teeth opens up new possibilities of using this method as an alternative to whitening or pre-treatment before other dental procedures.
Effect of Laser on the Interface and Thermal Conductivity of Metallized Diamond/Cu Composite Coatings Deposited by Supersonic Laser Deposition
Authors: Chen Yiyun , Zhang Qunli , Li Bo , Chen Zhijun , Liu Shaowu , Ma Xiaofei , Tofil Szymon , Yao Jianhua
Published: October 2024

To achieve the rapid heat dissipation of components in the industrial field, the heat dissipation coating is prepared on the surface, which is conducive to improving the service life of the parts and greatly reducing the industrial costs. In this paper, metallized diamond/Cu composite coatings were fabricated on 1060Al substrate by supersonic laser deposition. The composite coatings were prepared at a nitrogen pressure of 3.0 MPa, a scanning speed of 10 mm/s, and a 1060 nm semiconductor coupled fiber laser with different laser power. The research results show that the laser power affects the interface bonding by affecting the temperature of adiabatic shear instability during particle impact. The metallized diamond forms a good bonding at the interface through the plastic deformation of the Cu matrix. Appropriate parameters ensure that the jet does not affect the subsequent particle deposition and build a good heat transfer bridge to elevate the heat transfer efficiency. The coating prepared at a laser power of 1000 W has the highest thermal diffusion coefficient of 89.3 mm2/s and thermal conductivity of 313.72 W/(m·K), which is 8.92% higher compared to the coating prepared without laser. Experiments with thermal imaging have also demonstrated that the coating at optimal parameter transferred heat faster. Our research provides a technical guidance for rapid preparation of high-quality heat dissipation coatings in industry.