bluuebunny/crossref_metadata_2025 huggingface dataset:
Current GPS Deformation Characteristics of Southern North China and its seismicity
Authors: Gao Jiayi , Lu Xiaofei , Zhang Yang , Sun Jie
Published: February 2024

Using GPS data from 1998 to 2020, this study investigates the characteristics of the current crustal horizontal velocity field in Southern North China and adjacent areas. The relationship between deformation characteristics and earthquake activity, as well as the activity of major faults in the study area, are analyzed based on the spatial variations of regional crustal main strain rate field and surface dilatation strain rate field, and the distribution of earthquakes with magnitudes greater than or equal to 3. The results show that: (1) The GPS velocity field has an increasing trend from the northern North China Basin to the southern North China Basin and the Qinling-Dabie Orogen, but the overall movement rate is lower than that of the South China Block. (2) The distribution of earthquakes with magnitudes 3.0-5.9 is closely related to fault structures, while earthquakes with magnitudes greater than 6 are more closely related to regional crustal deformation characteristics, mainly occurring in the transition zone between areal expansion and areal compression. (3) The crustal deformation field can more intuitively indicate the movement characteristics of major faults in the study area. Major faults with strike-slip properties correspond to compressive deformation characteristics, while significant normal faults mainly exhibit extensional deformation characteristics. The segmentation and changes in the extension direction of faults are closely related to the transformation of crustal deformation characteristics. (4) These findings can provide a scientific basis for urban planning and site selection of important engineering projects, in addition to assessing the risk of earthquakes in the study area.
Impact of Dividend Regulation on Islamic Banking Performance in Pakistan
Authors: Iqbal Muhammad Saeed , Fikri Sofi Mohd
Published: February 2024

Islamic banks operate in a similar environment but have different dividend regulations. There appears to be a lack of agreement regarding Pakistan's dividend regulations. Dividend distribution is essential to a company's financial success, but it has not yet been resolved in the finance field. In Pakistan, this study was undertaken to determine whether dividend distribution regulation has a significant impact on Islamic banking's financial performance. This study has the following specific objectives: to examine the impact of RIBA on Islamic banking performance in Pakistan; and to determine the impact of dividend payout ratio on that performance. A theoretical framework was developed based on dividend irrelevance and signal impact. The study was conducted with a descriptive research design A study of all five Islamic financial institutions registered with SBP was performed. During (2019-2023), data was collected. Using a secondary data collection sheet of paper, secondary data was obtained from the State Bank of Pakistan's Supervisory Reports. Secondary data was also collected from Islamic banks. Data processing and analysis were performed with STATA software version 13. Panel data regression and descriptive analysis were conducted to analyze the data. The results were presented in tables and figures. The data were analyzed using multiple regression models, and SPSS version 21 was selected as the data analysis program. Statistics show 76.9% of Islamic banks fail to generate sufficient income to cover financing costs. There are three types of operating costs: total operating costs, loan loss reserves, and financing costs excluding capital costs. According to the analysis of variance (ANOVA) table, the predictor factors significantly impacted the predictor variable at the 5% level of significance. Islamic banking organizations perform by 0.347 points for every unit change in dividend payout ratio or RIBA, respectively. Consequently, Islamic banking institutions must take advantage of all available borrowing opportunities in order to continue to operate in the lending sector. As well as reinvesting earnings in their business, they must also grow it.
Autistic recognition from EEG signals by extracted features from several time series models
Authors: Rajabioun Mehdi
Published: February 2024

Autism is a neurological and psychological disorder that typically manifests in childhood and persists into adulthood. It is characterized by atypical social, behavioral, and communication skills, as well as diminished attention to the surrounding environment. The detection and recognition of autism can contribute to the prevention of its development and the enhancement of social and communicational abilities. Various methods are employed for autism recognition, including questionnaire tests and neurological techniques. One such neuroimaging method is electroencephalography (EEG), which records the brain's electrical activities through sensors placed on the scalp. This paper proposes a method for identifying individuals with autism using EEG signals and features extracted from a multivariate autoregressive moving average (MVARMA) and multivariate integrated autoregressive(ARIMA) models. The approach begins by estimating active sources through source localization methods, followed by the application of a dual Kalman filter to estimate source activity. Subsequently, the MVARMA and ARIMA models are applied to the EEG sensor and active source data, enabling the calculation of model parameters. Principal component analysis is then utilized to select important parameters, and a K nearest neighbor classifier is employed to classify participants as either autistic or neurotypical. The results demonstrate superior classification performance, achieving higher accuracy compared to alternative methods. The proposed method yields superior classification outcomes when compared to other approaches, as it exhibits improved classification measures.
Package W2CWM2C: description, features and applications
Authors: Martínez Josué Polanco- , Fernández-Macho Javier
Published: February 2024

This article describes new graphical tools that help with the interpretation of wavelet correlation and cross-correlation analysis, in both bivariate and multivariate cases. We have created an R package called W2CWM2C with the following main functions: Wavelet (Cross) Correlation and Wavelet Multiple (Cross) Correlation. To illustrate its strengths, we use data from several European Union stock market indices, comparing the new graphical output with the classical plots.
Reabilitação Oral com Overdenture Mandibular Retida por Raízes: Relato de Caso
Authors: Pereira Emezaque Kennedy Costa , Pinheiro Lucas Teixeira , Soares Tamilles Barcellos , Bitencourt Sandro Basso
Published: February 2024

A reabilitação oral de pacientes com a presença de poucos dentes naturais muitas vezes se torna um desafio. O presente estudo tem por objetivo relatar um caso clinico onde a paciente se encontrava parcialmente desdentada no arco inferior e procurou a clínica odontológica do Centro Universitário do Espirito Santo – UNESC para realizar uma prótese total inferior. Após exame clínico e radiográfico, foi observada a presença de somente dois dentes inferiores, os elementos 34 e 43. O plano de tratamento foi definido, com objetivo de reabilitar a saúde bucal, devolvendo função, estética e autoestima através de uma overdenture mandibular suportada sobre raiz. Esse método reabilitador contribui para a preservação do rebordo alveolar que, juntamente com o sistema de retenção implementados nas raízes dos dentes naturais, melhoram significativamente a retenção, suporte e estabilidade da prótese. A overdenture sobre raiz é uma opção de tratamento consolidada, vantajosa e eficaz, que aumenta significativamente a eficiência mastigatória quando comparada a prótese total convencional.
The study of the efficiency evaluation of the ventilation system of the poultry house in the summer
Authors: Hajiyev Rovshan , Huseynova Mehriban , Taghiyev Urfan , Mammadov Gabil , Allahverdiyeva Gahira
Published: February 2024

With the onset of cold weather, heat transfer through the walls and especially the roofs of bird rooms, unlike in the summer period, increases significantly, which leads to a sharp decrease in warm indoor air. Therefore, in order to maintain the regulatory conditions of the ventilation system, it is reduced to a transitional mode, and then to a minimum ventilation mode. Low ventilation repeatability limits inside the building determine the minimum volume of air supplied by the ventilation system. The economic and production efficiency of poultry farming is related to the premises and climatic conditions, which can seriously affect the well-being of broilers. Heat stress contributes to behavioral, physiological and biochemical changes in broilers, which leads to economic losses.

The purpose of this study is to influence the annual efficiency of the poultry house ventilation system, mainly in summer, in order to evaluate the efficiency during the reconstruction of the cooling system, that is, to improve the ventilation system of the room, as well as to give an economic assessment of waste disposal technology.

Energy– and resource-saving, environmentally friendly technologies and technological tools, plastic-type recuperators, a bird droppings removal system, as well as lighting and irrigation processes were taken as the object of the study. In conducting our research, let’s use classical and special methods, including a decomposition method for analyzing the functional use of recycling technology, a logical and linguistic method for assessing the safety of nitrogen during disposal, microclimate technology, nutrition and storage.

Based on the mathematical model, a computer research methodology was developed to improve the energy efficiency of the poultry house. Using a computer program, the number of LEDs (α=200, I0=20 cd) for an enclosure measuring 66×12 m is N=273 pieces, and the number of LEDs (α=200, I0=20 cd) for a building measuring 78×18 m is N=259 pieces. The design parameters of the illuminators are justified
Integrability and complexity in quantum spin chains
Authors: Craps Ben , De Clerck Marine , Evnin Oleg , Hacker Philip
Published: February 2024

There is a widespread perception that dynamical evolution of integrable systems should be simpler in a quantifiable sense than the evolution of generic systems, though demonstrating this relation between integrability and reduced complexity in practice has remained elusive. We provide a connection of this sort by constructing a specific matrix in terms of the eigenvectors of a given quantum Hamiltonian. The null eigenvalues of this matrix are in one-to-one correspondence with conserved quantities that have simple locality properties (a hallmark of integrability). The typical magnitude of the eigenvalues, on the other hand, controls an explicit bound on Nielsen’s complexity of the quantum evolution operator, defined in terms of the same locality specifications. We demonstrate how this connection works in a few concrete examples of quantum spin chains that possess diverse arrays of highly structured conservation laws mandated by integrability.
Interculturalidad. Lenguaje del mundo y de la humanidad
Authors: Fornet-Betancourt Raúl
Published: February 2024

La interculturalidad, antes que ser un método o una teoría para comprender el mundo y la humanidad que somos, constituye una dimensión fundamental del proceso histórico por el que el mundo y la humanidad van desarrollando en el tiempo sus formas de realidad y de convivencia.
Assistência estudantil: Uma avaliação a partir do desempenho acadêmico dos discentes da Universidade de Brasília (UnB)
Authors: Ferreira Marília de Faria , De Almeida Alexandre Nascimento , Cabello Andrea Felippe , Angelo Humberto
Published: February 2024

A efetividade de políticas de acesso e democratização do ensino superior (Cotas, FIES, REUNI, entre outras no Brasil) depende da qualidade das políticas de permanência como, por exemplo, a Assistência Estudantil. O descompasso entre essas políticas pode levar a evasão e/ou prejuízos na formação dos estudantes. A avaliação de políticas públicas no Brasil é escassa, essencialmente na área de educação, onde qualquer dispêndio de recurso é considerado investimento e, comumente, apreciado como inquestionável. Este estudo contribui para a avaliação dos programas de assistência estudantil na Universidade de Brasília (UnB). O objetivo foi de avaliar o efeito da assistência estudantil no desempenho acadêmico dos estudantes. Foram utilizados Testes-t para comparação de médias do desempenho acadêmico: antes e após a concessão da assistência estudantil e entre os alunos contemplados e não contemplados com o benefício. Os resultados ensejam que a assistência estudantil na UnB não impactou no desempenho acadêmico dos estudantes ou esse efeito é muito pequeno ou ocorre de forma defasada, portanto não amenizando dificuldades de desempenho no curto prazo. Os resultados contribuem com reflexões quanto a efetividade dos programas de assistência estudantil, tendo em vista que o desempenho acadêmico dos estudantes está relacionado com os objetivos previstos na política brasileira de assistência estudantil, bem como desperta a realização de outras pesquisas para melhor compressão do impacto da assistência estudantil.
Dinâmica das empresas multinacionais chinesas: Uma análise comparativa
Authors: de Carvalho Danielle Evelyn , Cechin Alicia , Truzzi Bruno
Published: February 2024

A intensificação do processo de desenvolvimento da China e o surgimento de grandes empresas chinesas produziu profundo impacto na estrutura geopolítica internacional. A superioridade econômica dos Estados Unidos foi colocada sob ameaça com o crescimento da China e a expansão das multinacionais chinesas. Propõe-se compreender o processo de expansão das multinacionais chinesas e sua consolidação como importantes agentes da economia global, comparando-se indicadores financeiros (das empresas) e econômico-estruturais (dos países) entre as principais potências do capitalismo mundial, dentre as quais os Estados Unidos, Japão, Reino Unido, França e Alemanha. As análises revelam a expansão das multinacionais chinesas desde os anos 2000, em detrimento de uma redução das transnacionais de outros países, especialmente dos Estados Unidos e do Japão. Essa expansão se concentrou especialmente no setor de finanças, com importante relevância dos bancos, devido ao papel que desempenham na escolha de projetos para o desenvolvimento nacional e regional do país.
Modelos Lineares Assistidos por Redes Neurais para Estimação Online da Energia do Calorímetro de Telhas do ATLAS
Authors: Gonçalves Guilherme , Libotte Gustavo , Peralva Bernardo , Andrade Filho Luciano , Balabram Filho Luiz Eduardo , Seixas José Manoel
Published: February 2024

O experimento ATLAS no LHC esta passando por uma atualização significativa, dividida em duas fases, para lidar com a alta luminosidade do LHC. Na Fase-II, prevista para entrar em operação em 2029, haver a uma evolução da arquitetura eletrônica de leitura, permitindo a realocação dos componentes eletrônicos visando a implementação do modo free-running de processamento digital de sinais. Durante esta fase de operação, espera-se um aumento substancial no numero de interações de partículas por colisão, o que pode apresentar desafios para os algoritmos de processamento de sinais, especialmente para os calorímetros onde as flutuações causadas pelo efeito de empilhamento de sinal degradam a resolução de energia. O método do Filtro ótimo, utilizado atualmente no calorímetro de telhas do ATLAS, busca minimizar a variância do ruído eletrônico, mas pode resultar em erros sistemáticos quando os pulsos se sobrepõem, levando a uma estimativa imprecisa da amplitude do sinal em cenários de alta luminosidade e de processamento ininterruptos de sinais. Neste trabalho, avaliamos a alternativa de usar o método de mínimos quadrados, que busca encontrar um estimador que minimize a diferença entre os dados observados e o modelo do sinal, sujeito a restrições lineares. Esta estrategia e conjugada com o emprego de uma rede neural perceptron multicamadas, visando a sua atuação como um corretor não-linear das estimativas da energia estimada pelo método de mínimos quadrados, tornando este significativamente mais preciso.
TÜRKİYE’DE TARİKATLARIN SİYASİ VE EKONOMİK ALANLARDAKİ SEKÜLER YÜKSELİŞİ VE YOKSULLAR / YOKSULLUK
Authors: Ateş Hakan
Published: February 2024

Max Weber’in “Protestan Ahlakı ve Kapitalizm” adlı çalışmasının yayımlandığı 1905 yılından bu yana dinin insanların ekonomik etkinlikleri üzerindeki etkilerine ilişkin bir tartışma süregelmektedir. Weber’e göre Protestan inancın insanları çalışmaya teşvik etmesi nedeniyle Protestan devletler başarılı bir ekonomik yaşam sürmektedir. Dahası, Batı’da inanç vasıtasıyla dünyevi çalışmaların önem kazanması ile ekonomik gelişim hızlanmıştır. Böylece, Batı bu ekonomik gelişmelerle siyasi konjonktürünü değiştirmiş ve Osmanlı bu konjonktüre ayak uyduramamıştır. Bu ortamda Osmanlı’daki tarikatlar / cemaatler, Batılılaşma hareketinin önündeki engel olarak kapatılmıştır. Ancak, 1960’lı yıllarda oluşan yeni siyasi akımlarla bu cemaatler hem ekonomik hem de siyasi alanda kendilerini görünür kılmaya başlamışlardır. Bu FETÖ-PDY gibi “sözde” cemaatler, terör örgütü olarak hareket edip insanların dini duygularını suiistimal ederek, yoksullar için para toplamış ve bu paralarla kendilerine bir ekonomik güç oluşturmuştur. Bu çalışmada, günümüzde FETÖ-PDY örgütü gibi “cemaat” adıyla Türkiye’de ekonomi ve siyaset alanında yer alan gruplara ve bu grupların dünyevi alandaki “yoksulluk” sorununa karşı tutumlarına ışık tutmak amaçlanmaktadır.
OBTENÇÃO DE AMINAS PRIMÁRIAS A PARTIR DA REDUÇÃO DE NITROCOMPOSTOS AROMÁTICOS VIA PROTOCOLOS DE REAÇÕES SUSTENTÁVEIS PARTE II: EM MEIO ORGÂNICO
Authors: Pinto Ligia , Facchinetti Victor , Bernardes Breno , da Costa Thamires , da Silva Letícia , Macedo Daniel , de Oliveira Isabela , Vasconcelos Thatyana , de Souza Marcus Vinícius
Published: February 2024

SYNTHESIS OF PRIMARY AMINES FROM THE REDUCTION OF AROMATIC NITRO COMPOUNDS THROUGH SUSTAINABLE REACTION PROTOCOLS PART II: REACTIONS IN ORGANIC MEDIA. The reduction of nitroarenes is the main methodology to produce anilines, important precursors of building blocks, dyes, and drugs. Continuing our goal of describing sustainable methodologies for the reduction of nitroarenes to their respective anilines, herein we compile selected reaction protocols, using organic medium, reported from 2017 to 2023, in order to provide a comprehensive and complementary view of the new processes and catalysts developed during this period.
Análisis comparativo entre dos pautas metodológicas para la extracción de fitolitos en metates de la Sierra Nevada de Santa Marta
Authors: Sandoval Carabali Rober
Published: February 2024

El presente escrito tiene como principal objetivo mostrar los resultados de la contrastación de dos pautas metodológicas utilizadas para la extracción y análisis de fitolitos en materiales de molienda (Metates) procedentes de la Sierra Nevada de Santa Marta; para observar mediante porcentajes como los de extracción, degradación, fragmentación e índices de pureza, cuál de las pautas permitía una menor pérdida de información y, por ende, una mejor extracción e interpretación de los procesos de molienda efectuados en estos artefactos. Los análisis se realizaron sobre dos metates encontrados en la terraza 2 del sitio arqueológico 15, ubicado a 074°03'44.6'' W y 10°59'13.2'' N, en la microcuenca de la quebrada el Congo, Sierra Nevada de Santa Marta.
Los resultados del estudio comparativo situaron a la primera metodología, la cual implementó las pautas y reactivos utilizados en la extracción de fitolitos en sustratos, sobre la segunda que no empleó ningún reactivo. Además, las caracterizaciones permitieron la identificación de múltiples especies vegetales, entre las que se encuentran algunas reportadas por la etnohistoria y la arqueología como el Zea mays, y Manihot esculenta, que permite inferir que estos utensilios fueron usados para el procesamiento de múltiples especies, lo que permite que este estudio sea entendido como una primera aproximación puntual, teórica y metodológica a las dinámicas de procesamiento de los antiguos pobladores que habitaron la terraza 2 del sitio arqueológico 15 de la microcuenca el Congo, Sierra Nevada de Santa Marta.
Nas amarras das competências
Authors: Lopes Luís Augusto
Published: February 2024

Este artigo analisa a Resolução CNE/CP nº. 1, de 05 de janeiro de 2021, sobre as novas Diretrizes Curriculares Nacionais (DCN) para a Educação Profissional e Tecnológica (EPT) em comparação às normas por ela revogada, a partir de uma análise documental obtida através da codificação eletrônica em software de análise qualitativa, e posterior análise do conteúdo político dos termos utilizados, bem como as relações estabelecidas entre eles. Tomou-se como base a concepção materialista histórico-dialética e os referenciais da pedagogia histórico-crítica, e observou-se uma ênfase ampliada nas competências profissionais. Sustentamos a tese de que a nova normativa está em consonância com vários movimentos do capital visando à manutenção da sua hegemonia, com atenção especial àqueles direcionados a uma captura mais intensa da subjetividade do trabalhador, e para a qual alega-se a necessidade de uma adequação do aparato escolar.
Pan-cancer Multi-omics Analysis Reveals HMGN1 as a Potential
Prognostic and Immune Infiltration-associated Biomarker
Authors: Guo Yangyang , Zhang Rongrong , Xu Hongjie , Hong Kai , Cen Kenan , Mai Yifeng , Wu Zhixuan
Published: February 2024

aims:

To investigate the expression of HMGN1 in different types of cancer and its potential role in cancer diagnosis and prognosis.

background:

The High Mobility Group N (HMGN) family of genes includes the High Mobility Group Nucleosomal Binding Domain 1 Gene (HMGN1), which is crucial for epigenetic regulation. However, the specific function of HMGN1 in cancer development is not known.

objective:

The High Mobility Group N (HMGN) family of genes includes the High Mobility Group Nucleosomal Binding Domain 1 Gene (HMGN1), which is crucial for epigenetic regulation. However, the specific function of HMGN1 in cancer development is not known.

method:

Raw data on HMGN1 expression were procured from Genotype-Tissue [removed]GTEx), the University of Alabama- Birmingham CANcer data analysis Portal (UALCAN), and The Cancer Genome Atlas (TCGA). Thereafter, the pan-cancer analysis was implemented to understand the HMGN1 expression patterns, prognostic value, and immunological features. Furthermore, the Gene Set Enrichment Analysis (GSEA) was executed with the help of the R language. In addition, the relationship between HMGN1 and the sensitivity of antitumor drugs was also determined. Finally, real-time PCR (RT-PCR) experiments were conducted to validate the differential expression of HMGN1.

result:

The findings of the pan-cancer analysis revealed that HMGN1 was upregulated in several solid tumors and was strongly associated with pathological staging and poor prognosis in several cancers. In addition, HMGN1 was found to be involved in regulating the TIME. The findings of the GSEA enrichment analysis indicated that HMGN1 assisted in the regulation of oncogenic processes, especially metabolic and immune pathways. Furthermore, HMGN1 expression was linked to microsatellite instability (MSI) and tumor mutational burden (TMB) in a variety of tumors. RT-PCR assays indicated that HMGN1 was significantly overexpressed in the gastric and breast cancer cell lines and tissues.

conclusion:

This study highlighted the potential of the epigenetic regulator, HMGN1, as an oncogene and a biomarker for pan-cancer analysis.

other:

None
A Five-gene Signature based on MicroRNA for Predicting Prognosis
and Immunotherapy in Stomach Adenocarcinoma
Authors: Wang Tianwei , Chen Piji , Li Tingting , Li Jianong , Zhao Dong , Meng Fanfei , Zhao Yujie , Zheng Zhendong , Liu Xuefei
Published: February 2024

Aims:

We aimed to classify molecular subtypes and establish a prognostic gene
signature based on miRNAs for the prognostic prediction and therapeutic response in
Stomach adenocarcinoma (STAD).

Background:

STAD is a common diagnosed gastrointestinal malignancy and its heterogeneity
is a big challenge that influences prognosis and precision therapies. Present study
was designed to classify molecular subtypes and construct a prognostic gene signature
based on miRNAs for the prognostic prediction and therapeutic response in STAD.

Objective:

The objective of this study is to investigate the molecular subtypes and prognostic
model for STAD.

Methods:

A STAD specific miRNA-messenger RNA (mRNA) competing endogenous
RNA (ceRNA) network was generated using the RNA-Seq and miRNA expression profiles
from The Cancer Genome Atlas (TCGA) database, in which miRNA-related mRNAs
were screened. Molecular subtypes were then determined using miRNA-related genes.
Through univariate Cox analysis and multivariate regression analysis, a prognostic model
was established in GSE84437 Train dataset and validated in GSE84437 Test, TCGA,
GSE84437 and GSE66229 datasets. Immunotherapy datasets were employed for assessing
the performance of the risk model. Finally, quantitative reverse transcription-polymerase
chain reaction (qRT-PCR) was applied to validate the expression of hub genes used for
the risk score signature.

Results:

We constructed a ceRNA network containing 84 miRNAs and 907 mRNAs and
determined two molecular subtypes based on 26 genes from the intersection of TCGASTAD
and GSE84437 datasets. Subtype S2 had poor prognosis, lower tumor mutational
burden, higher immune score and lower response to immunotherapy. Subtype S1 was
more sensitive to Sorafenib, Pyrimethamine, Salubrinal, Gemcitabine, Vinorelbine and
AKT inhibitor VIII. Next, a five-gene signature was generated and its robustness was validated
in Test and external datasets. This risk model also had a good prediction performance
in immunotherapy datasets.

Conclusion:

This study promotes the underlying mechanisms of miRNA-based genes in
STAD and offers directions for classification. A five-gene signature accurately predicts
the prognosis and helps therapeutic options.
Mannose: A Promising Player in Clinical and Biomedical Applications
Authors: Chen Sijing , Wang Kana , Wang Qiao
Published: February 2024

:

Mannose, an isomer of glucose, exhibits a distinct molecular structure with the same formula
but a different atom arrangement, contributing to its specific biological functions. Widely distributed
in body fluids and tissues, particularly in the nervous system, skin, testes, and retinas, mannose
plays a crucial role as a direct precursor for glycoprotein synthesis. Glycoproteins, essential for
immune regulation and glycosylation processes, underscore the significance of mannose in these
physiological activities. The clinical and biomedical applications of mannose are diverse, encompassing
its anti-inflammatory properties, potential to inhibit bacterial infections, role in metabolism regulation,
and suggested involvement in alleviating diabetes and obesity. Additionally, mannose shows
promise in antitumor effects, immune modulation, and the construction of drug carriers, indicating a
broad spectrum of therapeutic potential. The article aims to present a comprehensive review of mannose,
focusing on its molecular structure, metabolic pathways, and clinical and biomedical applications,
and also to emphasize its status as a promising therapeutic agent.
Risk Factors and Prognosis of Early Neurological Deterioration after
Bridging Therapy
Authors: Xie Yiju , Li Shengyu , Liu Liuyu , Tang Shiting , Liu Yayuan , Tan Shuangquan , Liang Zhijian
Published: February 2024

Background:

Early neurological deterioration (END) after bridging therapy (BT) of
acute ischemic stroke (AIS) patients is associated with poor outcomes.

Objective:

We aimed to study the incidence, risk factors and prognosis of END after BT.

Methods:

From January to December 2021, the clinical data of AIS patients treated by BT (intravenous
thrombolysis with alteplase prior to mechanical thrombectomy) from three comprehensive
stroke centers were analyzed. Patients were divided into non-END group and END
group according to whether they developed END within 72 hours of symptom onset. Modified
Rankin scale (mRS) was used to assess the patient’s prognosis at 90 days, and favorable outcomes
were defined as mRS≤2. The incidence of END was investigated, and binary logistic regression
analysis was used to explore its associated factors.

Results:

The incidence of END after BT was 33.67%. The eligible 90 patients included 29 cases
in the END group and 61 cases in the non-END group. Multivariate Logistic regression analysis
showed that increase of systolic blood pressure (SBP) (OR=1.026, 95%CI:1.001-1.051, p
=0.043), higher level of blood glucose at admission (OR=1.389, 95%CI:1.092-1.176, p =0.007)
and large artery atherosclerosis (LAA) subtype (OR=8.009, 95%CI:2.357-27.223, p =0.001)
were independent risk factors of END. Compared with the non-END group, the END group had
significantly lower rates of good outcomes (6.90% versus 65.57%, p =0.001) while higher rates
of mortality (44.83% versus 4.92%, p =0.001).

Conclusion:

It was found that the incidence of END after BT in AIS patients was 33.67%. An
increase in SBP, higher glucose levels at admission, and LAA were independent risk factors of
END that predicted a poor prognosis.
Association between Oxidative Balance Score and Severe Headache or
Migraine among American Adults A Cross-Section Study
Authors: Geng Dandan , Liu Huanxian , Wang Haoyuan , Dong Zhao , Wang Hebo
Published: February 2024

Background:

Migraine is implicated in oxidative stress. The oxidative balance score
(OBS) assesses the combined impact of diet and lifestyle on oxidative and antioxidant balance in
diseases. However, the association between OBS and migraine remains underexplored.

Objective:

We aimed to examine the relationship between OBS and severe headaches or migraines
among American adults

Methods:

This cross-sectional study utilized data from the National Health and Nutrition Examination
Survey (NHANES) 1999-2004, defining severe headaches or migraine via self-reports
and calculating OBS from 16 diaries and 4 lifestyle factors. Multivariable weighted logistic regression
models were used to explore the OBS-migraine relationship, with stratified analysis for
result validation.

Results:

The study included 6,653 participants (average age 45.6, 52.1% male), and 19.1% reported
severe headaches or migraines. There was a significant inverse association between OBS
and severe headache or migraine, with an adjusted odds ratio (OR) of 0.97 (95% [confidence
interval] CI: 0.96, 0.98, p < 0.001). The highest OBS tertile had an adjusted OR of 0.58 (95%
CI: 0.47, 0.73) compared to the lowest. This pattern was consistent across sexes, with an adjusted
OR of 0.98 (0.95, 1.00) in males and 0.97 (0.95, 1.00) in females. The adjusted OR for migraine
was 0.61 (0.44, 0.87) and 0.54 (0.37, 0.79) in the highest tertile for males and females,
respectively.

Conclusion:

The study highlights a significant association between OBS and severe headaches
or migraines, suggesting the potential role of oxidative stress in these conditions. The findings
emphasize the importance of a balanced, antioxidant-rich diet and lifestyle in managing severe
headaches or migraine.
Enlarged Perivascular Space in the Basal Ganglia is Associated with Cerebral
Venous Reflux in Patients with Recent Small Subcortical Infarction
Authors: Wu Zhengrong , Zhang Ke , Zong Ce , Liu Hongbing , Wang Yanhong , Xu Yuming , Gao Yuan
Published: February 2024

Background:

Research has linked enlarged perivascular spaces (EPVS) to cerebral
venous reflux (CVR) in patients with hypertensive intracerebral hemorrhage, but it is unclear
whether this association exists in recent small subcortical infarct (RSSI) patients.

Objective:

This study aimed to investigate the correlation between EPVS and CVR in patients
with RSSI.

Method:

This study included 297 patients, selected from patients with RSSI in the lenticulostriate
artery admitted to the Department of Neurology of the First Affiliated Hospital of Zhengzhou
University. CVR was assessed by time-of-flight magnetic resonance angiography (TOF-MRA).
The relationship between EPVS and CVR was studied using multiple logistic regression analysis.

Results:

This study included patients with an average age of 59.84±12.27 years, including 201
males (67.7%). CVR was observed in 40 (13.5%) patients. Compared to the group without CVR,
the proportions of male patients and patients with a history of smoking and drinking were higher
in the CVR group. The proportions of high-grade EPVS in the centrum semiovale region [23
cases (57.5%) vs. 108 cases (42.0%), p =0.067] and the basal ganglia region [30 cases (75.0%)
vs. 133 cases (51.8%), p =0.006] were higher in the CVR group. After multiple logistic regression
analysis, high-grade EPVS in the basal ganglia region was still associated with CVR (OR,
2.68; 95% CI, 1.22-5.87; p =0.014).

Conclusion:

In the population with RSSI, EPVS in basal ganglia is significantly associated with
CVR, suggesting a close relationship between venous dysfunction and the formation of EPVS.
A Case Report of Chronic Inflammatory Demyelinating Polyneuropathy
following COVID-19 Vaccination
Authors: Karbasforooshan Hedyieh , Amini Shahram , Boostani Reza , Mousavian Pourandokht , Hosseinjani Hesamoddin
Published: February 2024

Introduction::

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is a peripheral
polyneuropathy. Chronic damage to neuronal myelin by the immune system results in inflammation
and demyelination of the peripheral nervous system. Several side effects have been reported
with Coronavirus disease 2019 (COVID-19) vaccines. There are some reports of vaccineinduced-
CIDP. In this study, we described the occurrence of CIDP in a patient with a history of receiving
the first dose of a COVID-19 vaccine, Sputnik V.

Case Report::

We presented a patient receiving the COVID-19 vaccine Sputnik V two weeks before
progressive flaccid tetraparesis and dysautonomia. He was first diagnosed with Guillain-
Barre Syndrome (GBS). Two episodes of worsening the weakness occurred within 8 weeks
from the onset of the disease, and the treatment was repeated as GBS-Treatment-related Fluctuations
(TRF) and relapse. Also, a few relapses happened eight weeks after the disease's onset.
Hence, he was diagnosed with “acute-onset CIDP”. The patient received several intravenous immunoglobulin
(IVIG) courses as maintenance therapy. No further deterioration was reported during
the follow-up.

Conclusion::

Post-vaccination GBS is a known phenomenon. However, there are several reports
of vaccine-induced-CIDP. This is the first reported case of acute-onset CIDP associated with the
Sputnik V vaccine in Iran. Subsequent studies are required to determine the definite relationship
between COVID-19 vaccination and CIDP.
Probiotics as an Adjunct Approach to the Prevention and Treatment of
Colon Cancer: A Review
Authors: Kumar Akash , Goyal Nandani , Pramanik Jhilam , Bawa Yashna , Singh Sudarshan , Prajapati Bhupendra
Published: February 2024

One out of every six people in the world is suffering from cancer disease. The major
causes of cancer are high consumption of tobacco, high body mass index, and alcoholic beverages
with low intake of a healthy diet and limited physical activity. Colon cancer is one of the leading
causes of cancer-related morbidity worldwide. In the past few years, probiotics have drawn a lot
of interest as potential preventive and therapeutic anticancer agents. This literature review addressed
both human and animal research that has explored the association between probiotics and
colon cancer. Probiotic administration has remarkable potential for the prevention and treatment
of colon cancer through various mechanisms such as inhibiting the growth of cancer cells via apoptosis,
improving immune activity, restoring gut microbiota, improving intestinal barrier properties,
synthesizing anticarcinogenic compounds, and degrading carcinogenic compounds. Therefore, probiotics
emerge as an adjunct therapy, holding the potential to significantly reduce the risk of colorectal
cancer.
Enhanced CT Findings in a Case of Recurrent Pelvic Follicular Dendritic Cell
Sarcoma
Authors: Feng Wenhan , Yu Mingchuan , Li Haibo
Published: February 2024

Introduction::

Follicular Dendritic Cell Sarcomas (FDCS)was first found in 1986; the specificity of the disease is its rarity, with an incidence of only 0.4%,
numerous doctors for its lack of understanding, the accuracy of imaging diagnosis is not great, which is easy to delay the treatment. This article
summarizes several characteristic imaging manifestations of FDCS to provide imaging physicians with an understanding of the imaging properties
of this rare disease. When faced with complex cases, the radiologist can consider this disease and include it in the differential diagnosis. FDCS
occurs mainly in lymph nodes, mainly in the head and neck. The main symptoms are fatigue, local pain, or painless mass. The treatment method is
not uniform, but scholars agree that we should strive for the opportunity of surgery as much as possible.

Case Presentation::

This paper reported a case of FDCS with pelvic recurrence 3 years after surgery. The patient was suspected to have lymphoma by postoperative
pathology in the local hospital, and it is recommended that the patient be reexamined regularly. A soft tissue mass was recently found again in the
left pelvic cavity. After an enhanced CT examination, the radiologist was skeptical of the previous diagnosis of lymphoma. Subsequently, a needle
biopsy was performed at Peking University Shougang Hospital. The pathological results rejected the prior diagnosis of lymphoma after
consultation with additional hospitals, and the patient was diagnosed with FDCS.

Conclusions::

The imaging manifestations of FDCS lack absolute specificity, but it also has imaging characteristics, such as large areas of necrosis in the huge
mass, rough mass calcification in the mass, enhanced scan showed “fast in and slow out” mode, and there were blood vessels in the tumor. FDCS
mainly occurs in lymph nodes and is easily misdiagnosed as GIST, inflammatory myoblastoma, lymphoma, etc. Radiologists should continue to
collect cases of this disease and include suspected cases in the differential diagnosis in clinical work.
Quality Evaluation of Banlangen Granule based on Bioassays of
Anti-influenzal and Anti-inflammatory Effects
Authors: Qian Xiu-yu , Zhang Ming-lu , Wu Yan-Lin , Ma Shuang-cheng , Liu Jin-mei , Kuang Yan-hui , Nie Li-xing
Published: February 2024

Objective::

In order to control the quality better, this study aimed to develop two bioassay
methods of Banlangen Granule (BLGG) based on its anti-influenza activity and antiinflammatory
activity and to verify the necessity of established methods by relating the results
tested by chemical methods.

Methods:

First, the bioassay methods for determining the biopotency of the anti-influenza effect
and anti-inflammatory activity were established and applied, taking neuraminidase and cyclooxygenase-
2 as disease targets, respectively. Secondly, the ultra-high-performance liquid
chromatography coupled photo-diode array detector (UPLC-PDA) technique was used to perform
fingerprints and quantify chemical compounds. Finally, the correlation analysis was performed
on the results of bioassay methods and chemical methods to assist in choosing the effective
quality markers for the BLGG.

Results::

Two accurate, stable, and repeatable bioassay methods were developed and applied to
the determination of 57 batches of samples. The chemical fingerprints and contents of seven
quality compounds were obtained based on UPLC-PDA methods. From the results of correlation
analysis, the highest intensity correlation between these quality markers was medium with
a r=0.495 (P<0.01), which indicates the need for establishing a bioassay method for BLGG.

Conclusion::

This present work illuminated that bioassay methods can be a great means to
evaluate the quality of BLGG effectively and also provided a paradigm case for the quality
control of other traditional Chinese medicine preparations.
Bone Marrow Mesenchymal Stem Cell-derived Exosomal microRNA-99b-5p Promotes Cell Growth of High Glucose-treated Human Umbilical Vein Endothelial Cells by Modulating THAP Domain Containing 2 Expression
Authors: Ruan Hongru , Shi Hui , Luan Wenkang , Pan Sida
Published: February 2024

Introduction:

Bone marrow mesenchymal stem cell-derived exosomes (BMSC-exos)
may function as novel candidates for treating diabetic wounds due to their ability to promote angiogenesis.

Materials and Methods:

This study investigated the effects of BMSC-exos on the growth and metastasis
of human umbilical vein endothelial cells (HUVECs) treated with high glucose (HG). The
exosomes were separated from BMSCs and identified. The cell phenotype was detected by 3-(4,5-
dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide and 5-ethynyl-2’-deoxyuridine, wound
healing, and transwell assays, while the number of tubes was measured via tube formation assay.

Result:

The RNA and protein expression levels were studied using reverse transcription-quantitative
polymerase chain reaction and western blotting, whereas integration of microRNA-99b-5p
(miR-99b-5p) with THAP domain containing 2 (THAP2) was confirmed via dual-luciferase reporter
and RNA pull-down assays. Results of transmission electron microscopy, nanoparticle
tracking analysis, and laser scanning confocal microscopy revealed that exosomes were successfully
separated from BMSCs and endocytosed into the cytoplasm by HUVECs. Similarly, BMSC-exos
were found to promote the growth of HG-treated HUVECs, while their growth was inhibited
by suppressing miR-99b-5p. THAP2 was found to bind to miR-99b-5p, where THAP2 inhibition
reversed the miR-99b-5p-induced effects on cell growth, migration, and tube numbers.

Conclusion:

In conclusion, miR-99b-5p in BMSC-exo protects HUVECs by negatively regulating
THAP2 expression.
A Review of Dysuria in Traditional Persian Medicine
Authors: Nazari Vida , Mofid Bahram , Hajimehdipoor Homa , Babaei Hanieh , Heydarirad Ghazaleh
Published: February 2024

Background:

Background: Dysuria is a very prevalent urinary symptom experienced by the majority
of people at least once over their lifetime. Despite the advantages of conventional medications
for the management of dysuria, in some patients, there is no thoroughly successful treatment, so
numerous patients have a tendency to use complementary or traditional treatments. Persian medicine
(PM) consists of the sum total of all the knowledge and practices used in identification,
prevention, and treatment in Iran from ancient times to the present. Persian Medicine (PM) manuscripts
are a valuable source of experiences of Iranian scholars over the centuries, which contain
a lot of information about medicinal herbs that have been used for dysuria.

Objectives:

The goal of this study was to assess the etiology of dysuria, its types, and treatment
according to the principles of PM.

Methods:

A literature search compiled some PM manuscripts, including the Canon of Medicine,
Exir-e-Azam, and Tebb-e-Akbari, on the concept of dysuria as a prevalent disorder to review the
etiology, types, and management of dysuria by PM scholars' approaches.

Results:

According to PM manuscripts, there are three main causes of dysuria. Also, dysuria was
treated with three major approaches, including lifestyle modification, food substances, medicinal
herbs, and finally, manual therapy.

Conclusion:

In conclusion, it seems while there are flaws in the conventional management of
dysuria, and PM recommendations have found empirical support over the centuries, some PM
treatments can be helpful to conventional medicine as complementary medicine; however, more
studies are necessary to confirm their effectiveness.
Formulation, Optimization and Evaluation of Dabigartan Etexilate
Encapsulated Solid Supersaturated Self-Nanoemulsifying Drug Delivery
System
Authors: Shanthi Nithya , Mittal Heena , Kumar Manish , Mahato Arun Kumar , Mishra Brahmeshwar
Published: February 2024

Objective:

The present study proposed Dabigatran Etexilate loaded solid supersaturat-ed self-nanoemulsifying drug delivery system (solid S-SNEDDS) for enhancement of payload, drug solubility, dissolution rate as well as minimization of drug precipitation.

Methods:

The study involved formulation optimization using the Box-Behnken design. The op-timal SNEDDS consisting of Caprylic acid (32.9% w/w), Cremophor EL (50.2% w/w) and Transcutol HP (18.8% w/w) as Oil, Surfactant and Co-surfactant, respectively were formulated and evaluated for particle size, PDI, Zeta potential and saturation solubility. The SNEDDS was further incorporated with PPIs for the preparation of supersaturated SNEDDS (S-SNEDDS) to in-crease the drug payload in the formulation. S-SNEDDS was converted to solid S-SNEDDS by ad-sorption onto the porous carrier i.e., Aerosil®200. The in-vitro drug release study was also con-ducted for solid S-SNEDDS.

Results:

SNEDDS had size, PDI, and Zeta potential of 82 nm, 0.347, -10.50 mV, respectively. SNEDDS enhanced the saturation solubility of the drug by 93.65-fold. Among PPIs, HPMC K4M showed the most effective response for the formulation of S-SNEDDS. The S-SNEDDS had a more substantial drug payload, which further increased the solubility by 150 times of pure drugs and 16 times of SNEDDS. Solid S-SNEDDS exhibited free-flowing properties. Reconstituted sol-id S-SNEDDS had acceptable size, PDI, and Zeta potential of 131.3 nm, 0.457, and -11.3 mV, respectively. In-vitro drug release study revealed higher drug dissolution and minimized drug pre-cipitation by SNEDDS compared to marketed products and pure drugs.

Conclusion:

Proposed nano-formulation was found to efficiently improve the aqueous solubility of the drug and avoid the drug precipitation, thereby avoiding drug loss and improving drug bioa-vailability.
Influence of LaMnO3 Nanocrystallite Size on its Optical and Raman Spectra
Authors: Shukur Mohd Abdul , Kumar K. Vijaya , Rao G. Narsinga
Published: February 2024

:

In the current study, nanocrystalline LaMnO3 perovskite was prepared by
combustion method and annealed at different annealing temperatures. The X-ray diffraction
(XRD) patterns provided evidence that the structure formed has a Rhombohedral
structure with R3 ̅c space group. The remarkable growth in the crystallite size,
reduction in microstrain, and dislocation density were observed with annealing temperature.
Ultraviolet-visible spectroscopy was used to determine the optical band gap
by the Tauc-plot method. The optical band gap was found to be 3.5 ± 0.4eV and 2.9 ±
0.5eV for 600°C and 1200°C annealed samples, respectively. The observed results
were influenced by crystallite size. Raman spectra of the LaMnO3 nanocrystallites
revealed five Raman-active modes, like out-of-phase rotation modes and bending
mode of MnO6 octahedra. Moreover, the intensity of vibrational modes also varied
significantly with annealing temperature.