bluuebunny/crossref_metadata_2025 huggingface dataset:
Regularity of center-outward distribution functions in non-convex domains
Authors: del Barrio Eustasio , González-Sanz Alberto
Published: June 2024

For a probability P in

R

d

${\mathbb{R}}^{d}$

its center outward distribution function F
±, introduced in V. Chernozhukov, A. Galichon, M. Hallin, and M. Henry (“Monge–Kantorovich depth, quantiles, ranks and signs,” Ann. Stat., vol. 45, no. 1, pp. 223–256, 2017) and M. Hallin, E. del Barrio, J. Cuesta-Albertos, and C. Matrán (“Distribution and quantile functions, ranks and signs in dimension d: a measure transportation approach,” Ann. Stat., vol. 49, no. 2, pp. 1139–1165, 2021), is a new and successful concept of multivariate distribution function based on mass transportation theory. This work proves, for a probability P with density locally bounded away from zero and infinity in its support, the continuity of the center-outward map on the interior of the support of P and the continuity of its inverse, the quantile, Q
±. This relaxes the convexity assumption in E. del Barrio, A. González-Sanz, and M. Hallin (“A note on the regularity of optimal-transport-based center-outward distribution and quantile functions,” J. Multivariate Anal., vol. 180, p. 104671, 2020). Some important consequences of this continuity are Glivenko–Cantelli type theorems and characterisation of weak convergence by the stability of the center-outward map.
Periodic solutions for a coupled system of wave equations with x-dependent coefficients
Authors: Deng Jiayu , Ji Shuguan
Published: June 2024

This paper is concerned with the periodic solutions for a coupled system of wave equations with x-dependent coefficients. Such a model arises naturally when two waves propagate simultaneously in the nonisotrpic media. In this paper, for the periods having the form

T
=

2
a
−
1

b

(

a
,
b

are positive integers

)

$T=\frac{2a-1}{b}\left(a,b \text{are\,positive\,integers}\right)$

and some types of boundary conditions, we obtain the existence of the time periodic solutions and analyze the asymptotic behaviors as the coupled parameter goes to zero, when the nonlinearities are superlinear and monotone, by using the variational method. In particular, the condition ess inf  η

ϱ
(x) > 0 is not required.
Deciphering the influenza neuraminidase inhibitory potential of naturally occurring biflavonoids: An in silico approach
Authors: Faloye Kolade O. , Ahmad Shaban , Oyasowo Olubunmi T. , Shalom Esther O. , Bano Nagmi , Olanudun Esther A. , Kelani Tawakalit O. , Aliyu Habeeb E. , Raza Khalid , Makinde Boluwaji I. , Alanzi Abdullah R.
Published: June 2024

Influenza infection poses a significant threat to the existence of humans and animals. Its inhibition by secondary metabolites may proffer a lasting solution to its resistance to available synthetic therapeutic agents. In this study, we investigated the influenza neuraminidase (NA) inhibitory potential of naturally occurring C–O–C biflavonoids using integrated computational approaches. The molecular docking method was employed to identify biflavonoids with high binding affinities, and molecular dynamics simulation was performed for 100 ns to examine the stability, binding mode, and interactions elicited by the hit molecules in influenza NA-binding pocket. The bioavailability and pharmacokinetic properties of the hit biflavonoids were examined using swissADME. The molecular docking studies identified lophirone L, delicaflavone, lanaroflavone, pulvinatabiflavone, and ochnaflavone as the hit molecules with the binding affinity of −9.9 to −9.3 kcal/mol. The root means square deviation and root mean square fluctuation plots obtained from the molecular dynamics simulation showed that the selected biflavonoids were reasonably stable at the enzyme’s binding pocket. The ADMET studies showed that the top-ranked biflavonoids exhibit good pharmacokinetic and bioavailability properties. Furthermore, the density functional theory studies showed that the selected hit secondary metabolite possesses good pharmacological properties. Thus, the inhibitory activities of these compounds on viral neuraminidase could be helpful in the management of influenza infections.
Effect of water-absorbent polymer balls in internal curing on punching shear behavior of bubble slabs
Authors: Jaber Imtethal Helal , Awad Waryosh Waleed
Published: June 2024

The punching shear capacity of bubbled slabs is one of the main problems due to its decreased thickness; when there is inadequate curing, the problem becomes more critical, causing the building’s structural performance to deteriorate and exposing it to the risk of collapse. This study aimed to investigate the effect of using water-absorbent polymer balls in internal curing on the punching shear behavior of bubble slabs. Six concrete slabs were cast (1,000 mm × 1,000 mm × 70 mm). The main variables in this study are the type of slab (solid and bubble), type of curing (water and air), and ratio of water-absorbent polymer balls (5 and 10%). Studying the performance use of polymer balls and recycled plastic balls together and in normal strength concretes is limited. Also, investigating their behavior can provide insight into the efficiency of using these materials to improve concrete structures. Results showed that the most effective ratio for using polymer balls in internal curing is 5%, which had a good effect on the ultimate load, the first crack load, deflection, and crack pattern compared to the water-curing sample (reference sample). The water-absorbent polymer balls used in this study can absorb water when added to a concrete mixture. They release the water absorbed and subsequently contract, forming voids that are equivalent in size to the balls. This process facilitates internal curing while reducing the weight of concrete through the air voids left by the balls after they are dry.
Evaluation of aortic elasticity properties in mucopolysaccharidosis patients; effect of enzyme replacement therapy (ERT) on aortic stiffness
Authors: Ertas Kerem , Gul Ozlem , Bozacı Ayse Ergul , Bilgin Huseyin
Published: June 2024

Objectives

We aimed to cardiologically evaluate the consequences of glycosaminoglycan (GAG) accumulation in the large vessels of patients with mucopolysaccharidosis (MPS).

Methods

The left ventricular wall thickness, left ventricular mass (LVmass) were evaluated and aortic annulus diameter (AA), aortic sinus valsalva diameter (SV), sinotubular junction diameter (STJ), systolic aortic diameter (ADs), diastolic aortic diameter (ADd) body indices were obtained by dividing by the surface area. Aortic distensibility and stiffness index were obtained using aortic strain. Ejection fraction, mitral E and A velocities, mitral early diastolic tissue velocity (e′), E/A ratio, and E/e′ ratio were evaluated.

Results

The LVED-i, LVmass-i, AA-i, SV-i, STJ-i, ADs-i, and ADd-i values were significantly higher in the MPS group. While the E and e′ velocities and E/A ratio were significantly low in the MPS group, the A velocity and E/e′ ratio were significantly high. While the stiffness index, SBP, and PP values were significantly higher in the MPS group, the aortic strain and distensibility were significantly lower. There was a correlation between the stiffness index and the aortic strain, distensibility, SBP, PP, and ventricular function. Cardiac function, aortic diameter, and aortic elasticity characteristics were similar between patients with MPS who received ERT and those who did not.

Conclusions

In the MPS group, aortic elasticity properties were impaired, and aortic stiffness increased. ERT has positive effects on cardiac function, aortic diameter, and aortic stiffness in MPS patients. An increased LVmass-i and impaired ventricular geometric structure in patients with MPS may be associated with increased aortic stiffness.
Writing the Other: The Ethics of Out-Group Representation in Art
Authors: Holtug Nils
Published: June 2024

Recently, there have been cases in which out-group representation in art has faced severe criticism. Out-group representation occurs when an artist in her work engages with people, characters, or subject matters that do not fall within her own identity group. This is exemplified by the case of finding a translator for Amanda Gorman’s The Hill We Climb in the Netherlands, where the original choice was criticized because, unlike Gorman, the translator was not Black, and by the case of Dana Schutz’s painting of Emmett Till in his casket at the Whitney Museum in New York, which was criticized for being painted by a White person who could not understand the suffering Emmett Till and his mother had gone through. A number of objections to out-group representation are identified in the debate, namely, an objection from authenticity, an objection from equality of opportunity, and the suggestion that out-group representation is disrespectful and/or harmful. It is argued that none of these objections establishes that it is morally problematic to engage in out-group representation in art per se, although, importantly, there are a number of moral concerns that those who thus engage should be sensitive to.
Multilayer all-dielectric metasurfaces expanding color gamut
Authors: Gu Xin , Li Jiaqi , Liang Zhouxin , Wang Bo , Zhu Zhaoxiang , Chen Yujie
Published: June 2024

Structural color, arising from the interaction between nanostructures and light, has experienced rapid development in recent years. However, high-order Mie resonances in dielectric materials often induce unnecessary sub-peaks, particularly at shorter wavelengths, reducing the vibrancy of colors. To address this, we have developed a multilayer dielectric metasurface based on silicon-rich silicon nitride (SRN), achieving expanded color gamut through precise refractive index matching and suppression of high-order resonances. This strategy introduces more design dimensions and can reduce the complexity of material deposition. It enables the generation of vibrant colors in a 3 × 3 array, with a resolution of approximately 25,400 dpi, demonstrating its potential applications in displays.
Shattered lives, unbroken stories: journalists’ perspectives from the frontlines of the Israel–Gaza war
Authors: Fahmy Shahira S. , Salama Mohamed , Alsaba Mona Raafat
Published: June 2024

Purpose

This study sheds light on the unprecedented complexities of the Israel–Gaza war, offering insights into the challenges that journalists face in this conflict zone. It employs the Hierarchy of Influences Model to analyze the factors influencing conflict reporting within the dynamic landscape of contemporary war journalism.

Design/methodology/approach

Rooted in the Hierarchy of Influences Model, the research is informed by interviews with 18 Palestinian journalists in Gaza. It examines the multifaceted influences on war coverage, encompassing individual, media routines, organizational, and societal factors, offering detailed insights from journalists’ firsthand experiences.

Findings

The research unveils semi-hierarchical influences within the model, illustrating the intertwined nature of micro and macro-level factors impacting war reporting. It sheds light on the complexities of journalistic practices amidst conflicts, underscoring the importance of safety, ethics, and the intricate relationship between personal experiences and professional duties as well as the evolving role of technology, acting both as a facilitator and a limitation in journalistic endeavors.

Practical implications

The study holds substantial implications for war journalism practices, providing valuable perspectives for educators, policymakers, stakeholders, and media practitioners engaged in conflict reporting. It highlights the importance of understanding and addressing the challenges faced by journalists in conflict regions to enhance the quality and accuracy of war reporting.

Social implications

By uncovering the challenges and influences affecting war reporting, this research contributes to the broader discourse on media ethics, safety protocols, and the societal impact of conflict coverage. It emphasizes the need for comprehensive support systems and ethical guidelines to safeguard journalists operating in volatile regions.

Originality/value

Bridging academic and practical perspectives on conflict reporting, this study offers unique insights into reporting complexities in the Israel–Gaza War. It emphasizes the critical role of journalistic practices in navigating hazards and limitations, amid evolving challenges for the media in portraying conflicts accurately.
Random attractors for three-dimensional stochastic globally modified Navier–Stokes equations driven by additive noise on unbounded domains
Authors: Hang Ho Thi , Nguyen Pham Tri
Published: June 2024

This paper is devoted to study the three-dimensional globally modified Navier–Stokes equations driven by additive white noise on some unbounded domains 𝒪.
By using the Ornstein–Uhlenbeck process, we transfer the original equation to a random dynamical system, and then we prove the existence of pullback attractors for the random dynamical system equations under suitable conditions.
Due to the unboundedness of the domains, we get the asymptotic compactness of the solutions by Ball’s idea of energy equations.
The periodicity of the attractors is also proved when the deterministic non-autonomous external terms are periodic in time.
TRANSITION FROM THE CONTINENTAL MARGIN OF KAMCHATKA TO THE ISLAND ARC OF THE KURILE ISLANDS: FEATURES OF VOLCANISM, CRUSTAL DEFORMATION AND GEOPHYSICAL PARAMETERS OF THE SLAB
Authors: БЕРГАЛЬ-КУВИКАС О.В. , БУСЛОВ М.М. , БУШЕНКОВА Н.А. , ДОЛГАЯ А.А.
Published: June 2024

Проведен анализ проявления магматизма в зоне перехода от континентальной окраины Камчатки к Курильской островной дуге и геофизических параметров погружающейся под них океанической плиты Северо-Западной Пацифики. Наличие прибрежного вулканического комплекса миоценового возраста в основании вулканического пояса Южной Камчатки способствует интенсивным коровым процессам, которые, вероятно, привели к формированию кальдерообразующих извержений в голоцене. Для Северных Курил характерно формирование ареального вулканизма, приуроченного к разрывным нарушениям земной коры. Аномальным является отсутствие вулканизма на о. Шумшу, расположенном непосредственно вблизи Камчатки. Отсутствие вулканизма на этом острове связывается с высокоскоростной аномалией, фиксируемой по данным сейсмотомографии. На основе представленных данных выдвигается предположение о наличии океанического поднятия на слэбе, погружение которого привело к дезинтеграции зон плавления, отвечающих за формирование вулканизма.

Magmatism manifestations in the transition zone from the continental margin of Kamchatka to the Kurile island arc and some geophysical parameters of the subducted oceanic plate of the Northwestern Pacific are considered. The presence of the Miocene coastal volcanic (Pribrezhny) complex at the base of the South Kamchatka volcanic belt contributes to intense crustal processes causing caldera-forming eruptions in the Holocene. The Northern Kuriles are characterized by initiation of areal volcanism associated with crustal fault zones. Anomalous is the absence of volcanism on Shumshu island proximal to Kamchatka. Seismic tomography data reveal a high seismic velocity anomaly below it, which can explain this phenomenon. Based on the presented data an assumption is made about existence of a seafloor elevation on the slab, whose submergence led to disintegration of the melting regions responsible for generation of volcanism.
Institutionalization of confidence in monetary policy as a tool for attracting investments for the recovery of Ukraine's economy
Authors: Grytsenko Ruslan
Published: June 2024

One of the economic tasks of the Ukrainian government is to attract external foreign investments to rebuild the economy and expand its own national production, which entails other positive socio-economic effects. This study analyzes how monetary policy becomes an important tool for promoting the attraction of foreign investments through the institutionalization of trust in the National Bank of Ukraine (hereinafter – the NBU). The study identifies the main political and economic contradictions inherent in the instruments of monetary policy, due to which the importance of increasing trust in the NBU by ensuring its institutional independence is substantiated, in particular, via introducing high-quality corporate governance. It has been proven that institutionalized trust via the predictability of the use of monetary policy instruments, has a positive effect on Ukraine’s investment attractiveness, which increases the potential for this country’s economic recovery.
Біологічний захист рослин в Європейському Союзі (на прикладі Німеччини)
Authors: Іутинська Г.О. , Ямборко Н.А.
Published: June 2024

The application of ecological plant protection products against diseases, pests, and weeds is relevant for modern science-provided crop production. Much attention is paid to this problem in the European Union, where the use of pesticides is strictly adjusted by the European Food Safety Authority. Great hopes are pinned on biological plant protection products. However, among the thousands of biological products included in the BioPesticide DataBase, only a small number are authorized for use in agriculture. The requirements for the use of biological protectants in organic farming are even more stringent, regulating not only the properties of the product but also the crops in which they can be used. The aim of the work was to present the main requirements for the safety of biopesticides in the EU countries and to give an overview of biopesticides authorized for use in traditional and organic farming using Germany as an example. Methods. Analysis of EU documents on the requirements for registration of active substances in biological products for plant protection, biopesticide databases, and the list of biopesticides approved for use in general and organic farming in Germany. Results. According to the EU requirements for biopesticide safety, registration of biological plant protection products based on bacteria, fungi, and viruses, individual microbial cellular components or metabolites, as well as insect predators, pheromones, and plant-origin substances is allowed. Among the biopesticides with bactericidal and fungicidal effects registered in Germany, the preparations based on microbial antagonizing plant pathogens are prevalent, as well as preparations elaborated on the fungus Aureobasidium pullulans, Trichoderma asperellum, Verticillium albo-atrum, Coniothyrium minitans, bacteria Pseudomonas chlororaphis, Bacillus amyloliquefaciens, and also the preventive drug Cerevisan based on the cell walls of Saccharomyces cerevisiae. The following bioformulations based on Bacillus thuringiensis, Beauveria bassiana, Cydia pomonella Granulovirus, avermectin antibiotic Abamectine A, herbal products Azadirachtin A and Piretrin, and Maltodextrin are registered as insecticides. A bioformulation based on Bacillus firmus is authorized for use as a nematocide. Conclusions. Registration of biological plant protection products in Germany is carried out in accordance with the EU requirements for the safety of biopesticides. The list includes preparations based on antagonistic microorganisms, predatory microorganisms, microbial metabolites with antibiotic activity, substances for stimulation in plants nonspecific resistance to infectious agents. The fungicidal products are the widest represented. The number of products to control bacterial and nematode infections as well as the bioinsecticides spectrum is very limited. These are the well promising areas for further research and development of biological products.
The Nature of Pyroelectric Polarity
Authors: Poplavko Y.M.
Published: June 2024

The concept of spontaneous polarization in the pyroelectrics is called into a question, since omnipresent free electric charges make impossible to maintain any equilibrium and time-stable polarized state. We conjecture in this paper that pyroelectricity in polar crystals and piezoelectricity in polar-neutral crystals are due to hybridized ionic-covalent polarity-activating bonds. When they are in non-excited state, these bonds do not produce electric field, yet they are capable of generating the electric response to uniform non-electric influence, e.g., heat, pressure, etc. This response is described by some models of different electric moments. Different contributors to these moments can be measured using partial limitation of crystal thermal strain. In fact, the proposed approach modifies and extends the known concept of spontaneous polarization. In this context, ferroelectrics are distinguished by the fact that, in the electric field, they reorient their polarity-activating inter-atomic bonds with a non-linear response and hysteresis.
Комп’ютерно-інтегрована технологія проєктування та виготовлення індивідуальних ендопротезів
Authors: Бобир Микола Іванович
Published: June 2024

У доповіді наведено важливі та актуальні для України наукові й практичні результати зі створення методів проєктування і технологій виготовлення ендопротезів опорно-рухового апарату людини індивідуального призначення. Ці науково-дослідні роботи мають міждисциплінарний характер і виконуються в Національному технічному університеті України «Київський політехнічний інститут імені Ігоря Сікорського» у співпраці з Інститутом електрозварювання ім. Є.О. Патона НАН України, Державною установою «Інститут травматології та ортопедії НАМН України» та Українською військово-медичною академією Міністерства оборони України.
Modification of Coal Fly Ash Waste into Manganese-Oxide-Coated-Zeolite (MOCZ) to Adsorb Heavy Metal Ions Ni2+
Authors: Saputro Sulistyo , Mahardiani Lina , Susilowati Endang , Nurhayati Nanik Dwi , Ciptonugroho Wirawan , Windiasty Ananda Dea , Prihantoro Alita Selvi
Published: June 2024

High consumption of coal as a source of electrical energy in Indonesia has resulted in piles of waste from coal burning, namely fly ash, which can damage the environment and harm health. Fly ash contains main oxides, namely silica (SiO2) and alumina (Al2O3), whose components are similar to zeolite, so they can be synthesized into zeolite-like material (ZLM) which can be used as an adsorbent for heavy metal Ni2+. Therefore, this research discussed the characterization of manganese-oxide-coated-zeolite (MOCZ) from fly ash waste as a heavy metal adsorbent. The research procedure consisted of preparation, purification, and activation stage of fly ash to obtain fly ash that is free from impurities, the stage of making sodium silicate and sodium aluminate, and zeolite synthesis. The resulting zeolite was then coated with manganese oxide to expand the surface area of the zeolite and increase the ability of zeolite to adsorb heavy metal Ni2+. The research results showed that fly ash waste that was coated with manganese oxide can adsorb heavy metal Ni2+. The adsorption of the Ni2+ metal ion solution by zeolite with MOCZ modification is in line with the pseudo-second-order kinetic and Langmuir isotherm.
Mineralogía, granulometría y facies asociadas a sedimentos de fondo en tres embalses de Empresas Públicas de Medellín
Authors: Flórez-Molina María Teresa , Parra-Sánchez Luis Norberto
Published: June 2024

La mineralogía, la granulometría y las facies asociadas en los sedimentos de fondo de los tres embalses Riogrande II, La Fe y Porce II, permiten diferenciar tres episodios relacionados con la evolución de los medios sedimentarios, localizándose los depósitos limosos (episodio medio) en el contacto entre facies lacustres arcillosas (episodio inferior) y aluviales de orla distal arenoso (episodio superior). En estos embalses los datos promedios de los microcomponentes indican la predominancia de tres microfacies, inorgánica, organomineral y orgánica. El análisis de la composición granulométrica combinado con la estructura física del sedimento admite distinguir distintas áreas sedimentarias que reflejan un proceso de sedimentación poco selectiva a lo largo del embalse y que causan cierta heterogeneidad espacial de estos. En todos los casos las proporciones fueron mayores para las arenas, luego para los limos y, por último, para las arcillas.
Estudio comparativo para áreas mínimas en contacto con el suelo de zapatas aisladas rectangulares y circulares trabajando parcialmente bajo compresión
Authors: Luévanos-Rojas Arnulfo , Estrada-Mendoza Blanca Lucia , Juárez-Ramírez Mónico
Published: June 2024

Este trabajo presenta un estudio comparativo para áreas mínimas en contacto con el terreno de ZAR (zapatas aisladas rectangulares) y ZAC (zapatas aisladas circulares) que trabajan total MA (Modelo Actual) o parcialmente NM (Nuevo Modelo) a compresión. La metodología se describe utilizando las ecuaciones desarrolladas por el mismo autor para ZAR y ZAC. Principales hallazgos: las ZAR bajo flexión uniaxial tienen menos área que las ZAC en el MA y en el NM; El NM presenta menor área que el MA para ZAR y ZAC bajo flexión biaxial en todos los casos; El NM para ZAC muestra menos área que las ZAR, cuando los momentos son iguales y la relación de la carga axial dividida por el momento es 0.75 o mayor, cuando el momento más pequeño dividido por el momento más grande está entre 0.50 y 0.75, y la carga axial es mayor que el momento más grande. Por ello, se recomienda realizar un estudio previo para elegir el tipo de zapata.
Project Spotlight: Hollow-core structural flooring saves time on Massachusetts mixed-use project
Authors: Atkinson William
Published: June 2024

The Assembly Row mixed-use complex in Somerville, Mass., features 600,000 sq.ft. (56,000 sq.m.) of retail space, 2.8 million sq.ft. (260,000 sq.m.) of office space, and 1800 residential units. Block 5A of the project, called the Alloy Residences and Autograph Collection Hotel, features 122 high-end condo¬miniums in a 13-story building with an underground parking structure. Block 6 features a 20-story, 273-unit apartment building, along with a six-story, 174-unit wooden structure and a seven-story, 650-car precast concrete parking structure. For several reasons, designers specified precast concrete hol¬low-core for the structural flooring systems in both block proj¬ects. They selected J. P. Carrara & Sons Inc. of Middlebury, Vt., for the work.
Project Spotlight: Design-assist helps overcome challenges for precast concrete church project
Authors: Atkinson William
Published: June 2024

The efficient and creative use of precast concrete played a vital role in the recent construction of the new 1200-parishioner St. George Catholic Church in Baton Rouge, La. Gate Precast of Monroeville, Ala., was the precast producer for the project.
A new process related impurity identification, characterization, development of analytical method by HPLC and method validation for Voriconazole API
Authors: Epuru Manohar Reddy , Allaka Tejeswara Rao , Venna Ravinder Reddy , Narsimhula Shravan , Kishore Pilli Veera Venkata Nanda
Published: June 2024

During the testing of laboratory Voriconazole API batches, one unidentified impurity (IMP-5.312) was detected employing the Pharmeuropa HPLC technique at a level in excess of 0.10%. This IMP-5.312 was synthesized and then characterized as 6-(3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl) butan-2-yl)-5-fluoropyrimidin-4-ol by the corresponding spectral information (MS, 1H-NMR, 13C-NMR, and IR). The IMP-5.312 impurity was effectively quantified using an enhanced HPLC based-technique that was developed as well as validated. The approach made use of a Novapak C18 column with an inner diameter of 3.9 mm and a length of 150 mm (4.0 µm) for chromatographic separation. The analysis of IMP-5.312 was made at 45 °C, with a flow rate (isocratic) of 1.0 mL min−1 and a 256 nm detection wavelength. Acetonitrile, methanol, and 0.1% aqueous trifluoro acetate buffer (pH 4.0) were mixed at a ratio of 15:30:55 (v/v/v) to create the mobile phase for a 20 μL sample injection. The linearity range of 0.25281–1.51690 μg mL−1 had a correlation coefficient more than 0.99942, and the accuracy ranged from 89.3 to 100.3%. It was noted that the established HPLC based-technique was sensitive, specific, and precise. The technique was executed on the current batches of VRC API for IMP-5.312 analysis, and the outcomes were good. For quality control purposes during the manufacturing procedure of VRC, the identification as well as analysis of IMP-5.312 should be helpful. The in silico approach was applied to predict the IMP-5.312 toxicity. The reports indicated that IMP-5.312 in non-mutagenic and categorized as ICH M7 class-5 impurity.
Integrating STEM-related Technologies into Mathematics Education at a Large Scale
Authors: Lavicza Zsolt , Prodromou Theodosia , Fenyvesi Kristof , Hohenwarter Markus , Juhos Istvan , Koren Balazs , Diego-Mantecon Jose Manuel
Published: June 2024

This paper outlines the growing phenomenon and need to integrate technologies into mathematics and science teaching and learning. There are a number of successful projects for valuable integration of technologies around the world, however, these successes are often limited reaching
a relatively small number of teachers and students. In this paper, we aim to offer examples of large-scale technology projects that could create a critical mass of users that could further drive innovation and sustainability for educational technology integration. We outline how GeoGebra became
one of the most widely used dynamic mathematics software with a user base of more than 100 million; highlight directions of research for technology development and integration; and describe the Geomatech project that aimed to train 2500 teachers in 950 schools in Hungary. We hope that such
examples, the developed technology, resources and pedagogies could contribute to further valuable integrations of technologies in mathematics and science education.
Dynamic Geometry Systems in Proving 3D Geometry Properties
Authors: Ferrarello Daniela , Mammana Maria Flavia , Taranto Eugenia
Published: June 2024

A classroom activity for high-school students, aiming at introducing space geometry from plane geometry has been introduced back in 2009 by Mammana, Margarone, Micale, Pennisi and Pluchino (2009a). The activity was based on the use of a Dynamic Geometry System and of the analogy
between figures. Several aspects of the activity have been studied in different research studies. What we focus on, in this paper, is the power of the Dynamic Geometry System and of the analogy in the proof phase when working in a three dimensional environment, highlighting the cognitive process
evolving in some 3D geometry proofs, by using videos recorded during the activities in the classroom.
Visual Mental Images’ Connected Paper-and-Pencil Iconic and Non-Iconic Representations
Authors: Vágová Renáta , Kmetová Mária , Lavicza Zsolt
Published: June 2024

Although we move and live in three-dimensional space, many prefer “two-dimensional” thinking in mathematics lessons. As a result, the transition between physical objects and their graphical representations can be considered one of the most common difficulties in learning
and teaching solid geometry. This paper describes results of our quantitative-qualitative research focused on solving a non-standard spatial visualisation problem. Demanding mathematical operations are not required in its solution, but creating the right mental images of 3D objects and the
ability of their mental manipulation are key to the correct solution. Students’ paper-and-pencil solutions were the main source of research data and the principal aim of the study was to examine the relation between the number of correct external representations (iconic or non-iconic)
and the numerical scores in student solutions. In this article, we focus on the qualitative findings and supplement them with quantitative results.
Visualizing and Understanding Optimization Problems Using Dynamic Software
Authors: Gordon Sheldon P.
Published: June 2024

The article uses dynamic visualizations in Excel to examine a variety of ways in which students can attain a much greater depth of understanding of optimization problems in introductory calculus. The topics discussed include a variety of common optimization problems that appear in
virtually every calculus textbook that can all be enhanced dramatically using dynamic software that provides both graphical and numerical support to increase student understanding.
Research for Curricular Innovation in Action in the Mathematics Classroom
Authors: Galán-García José Luis , González-Marí José Luis , Padilla-Domínguez Yolanda , Rodríguez-Cielos Pedro
Published: June 2024

It is difficult for research in Mathematics Education to have any real impact on teaching practice in the classroom. Conscious of this, we have developed a research model for curricular innovation, involving the teachers responsible for its implementation, improving their training,
and providing scientific information whilst maintaining the integrity of the phenomena analyzed “where they occur and exactly as they occur”. The model is based on an analysis of the principal existing trends, and is tested in the development of Mathematical subjects at distinct
educational levels, chief among them university courses in Engineering, where mixed research methods are used to analyse the effect that carrying out commands in a Computer Algebra System (CAS) has on the performance and attitude of students taking various Mathematics courses. Each teacher
leads the study in his/her group and collaborates with the rest of the groups as an observer and assistant. Teaching protocols are employed in experimental and control groups; observation protocols, testing objectives, and individual questionnaires and interviews are also employed. The complete
analysis provides data that confirms the fitness of the specific innovations applied (with a notable improvement of more than one point over 10 with α = 0, 05), which enables a direct and solidlybased change to the programmes and the development of their corresponding curriculums.
Dynamic Investigation of Area Conservation Properties Using Computer Technology in a Classroom Activity
Authors: Oxman Victor , Stupel Moshe , Tal Idan
Published: June 2024

The article presents some examples of plane geometric variance of an area with the use of computer technology. These tools can offer teachers opportunities for adaptation and preparation of pedagogical presentations which will help students along the process of fruitful conjectures
formation and eventually construction of formal deductive proofs. Some of the examples are original, and all are beautiful and insightful. The mathematical proofs of the selected examples are very simple and do not require the use of any "heavy" mathematical tools. All the examples
have links to applets prepared in GeoGebra-Tube. The consequences of all the examples can be formulized as mathematical propositions, and vice versa, meaning any mathematical proposition might demonstrate a situation of variance and invariance properties.
Transient constrictive pericarditis in Bruton disease: a case report
Authors: Kruchinova S. V. , Skaletsky K. V. , Donets E. K. , Namitokov A. M. , Karibova M. V. , Kosmacheva E. D.
Published: June 2024

Introduction. Constrictive pericarditis is a long-term consequence of any pathological process developing in the pericardium due to fibrinous thickening and calcification of its layers, which prevents normal cardiac diastolic filling. One of its forms is transient constrictive pericarditis, which resolves after anti-inflammatory therapy.

Brief description. A 19-year-old man with Bruton disease was admitted to the clinic with complaints of severe weakness, shortness of breath at rest, cough, chest pain, hyperthermia to 380 C, decreased blood pressure to 80/60 mm Hg, and abdominal distension. During the initial echocardiography, the results did not raise serious suspicions. However, given the rather specific interventricular septum motion, pericardial constriction was suspected.

Discussion. During the additional examination, echocardiography made it possible to verify constrictive pericarditis, which was subsequently confirmed by heart catheterization. Due to significant immunoglobulin level deviations, a decision was made to resume immunoglobulin replacement therapy, followed by a clinical status reassessment.

The article presents a clinical description of a patient with constrictive pericarditis, which was a manifestation of Bruton disease. During follow-up, resolution of constriction was noted with resumption of immunoglobulin replacement therapy.
The role of intravascular physiological assessment of the significance of coronary involvement in patients with severe aortic stenosis
Authors: Petrosyan K. V. , Abrosimov A. V. , Goncharova E. S. , Chobanyan M. A.
Published: June 2024

As technology improves, the number of transcatheter aortic valve implantation (TAVI) procedures performed is steadily increasing. Due to the comparable outcomes with surgical treatment of aortic stenosis, TAVI is increasingly being performed in a group of younger patients. In this connection, there is an increasing need for a reasonable approach to assessing the severity of concomitant coronary lesions. Non-invasive studies in this group of patients have low sensitivity and specificity in identifying significant coronary narrowing. In addition, the use of stress testing is limited by the risks of potential complications due to the severity of patients with critical aortic stenosis. The assessment of fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR), which has become widespread in isolated coronary heart disease (CAD), in the case of a combination of CAD with aortic stenosis, requires careful study and analysis. The literature review shows that today there are the first results of using the assessment of coronary physiology to determine indications for myocardial revascularization in patients with aortic stenosis. New threshold values of FFR and iFR applicable for patients in this group are considered. The results of literature data indicate the need for large randomized studies to better understand the method capabilities and develop the most optimal approach to the treatment of TAVI candidates with concomitant CAD.
New concepts in blood pressure variability
Authors: Gorbunov V. M , Posokhov I. N
Published: June 2024

A review of the recent literature examines novel concepts in blood pressure variability (BPV) and their possible clinical significance. In our opinion, two approaches are promising, in which the underlying pathophysiological processes are considered in the form of a simple linear and more complex nonlinear model. Moreover, both approaches have a specific practical implementation as follows: the first — in the form of a scale, the second — in the form of new BPV parameters. The scale is intended to assess the severity of systemic hemodynamic atherothrombotic syndrome, which is the result of the synergistic interaction of vascular damage and hemodynamic stress accumulating over a long time. Novel indicators describe the beat-to-beat BPV, reflecting the preservation of regulatory mechanisms. The literature analysis also allowed us to suggest possible ways to improve these concepts.
Isolated cardiac sarcoidosis: a case report
Authors: Skomkina I. A. , Mordovin V. F. , Triss S. V. , Stepanov I. V. , Ryumshina N. I. , Polyakova M. A. , Batalov R. E. , Falkovskaya A. Yu.
Published: June 2024

Introduction. Ventricular arrhythmias are a risk factor for sudden cardiac death. Abnormalities of cardiac rhythm and conduction may be the only subjective manifestation of isolated cardiac sarcoidosis, which occurs in 25% of the total number of patients with this disease.

Brief description. We present a case of isolated cardiac sarcoidosis in a young female patient, the main clinical manifestation of which was attacks of palpitations caused by ventricular tachycardia and episodes of cardiogenic shock without a cardiovascular history. Echocardiography and contrast-enhanced cardiac magnetic resonance imaging (MRI) revealed asymmetric left ventricular hypertrophy and focal myocardial masses. Cardiac tumor and sarcoidosis were suspected. The final diagnosis was based on the results of histological and immunohistochemical analysis of endomyocardial biopsies documenting sarcoidosis. No systemic manifestations of sarcoidosis were found.

Discussion. The case demonstrates the potential of a comprehensive paraclinical study in the diagnosis of cardiac sarcoidosis and its differential diagnosis with other cardiac pathologies.

Conclusion. Cardiac sarcoidosis is difficult to diagnose and requires histological verification in patients with LV hypertrophy and arrhythmias, and physicians should be aware about this rare disease with unfavorable prognosis without specific treatment.
Perceived value and loyalty to WeChat: evidence from a sample of Chinese entrepreneurs living in Spain
Authors: Mecinas Cantos Rocío , Martínez Ruiz María del Pilar
Published: June 2024

This paper analyses the influence of functional value in the relationship with suppliers, functional value in communication with suppliers and functional value in business activities on the attitudinal and behavioural loyalty towards the WeChat social network by Chinese entrepreneurs based in Spain. To this end, several research hypotheses were proposed and tested by studying a sample of 57 Chinese entrepreneurs based in Spain. The results obtained from the regression models carried out show the key importance of the functional value variable in business activities on both types of loyalty; the functional value of communication with suppliers only exerted a significant influence on attitudinal loyalty
Flexural behaviour of geopolymer concrete beams with hybrid natural–synthetic fibre reinforcement
Authors: Rajendran Mohana , Athithan Krishna Kumar , Bakthavatchalam Karthiga
Published: June 2024

The requirement of excellent flexural stiffness in construction elements has initiated the use of fibre reinforcement. However, the processing complexity involved in the manufacture of synthetic fibres is environmentally hazardous. The use of natural fibres in geopolymer concrete (GPC) structures was investigated in this work using a hybridisation of natural and synthetic fibre. Natural basalt fibre (BF) was used with synthetic steel fibre (SF) in various proportions in GPC and tests were conducted to evaluate the workability, compressive strength, split tensile strength and flexural strength. It was found that, compared with the plain GPC, the addition of 1.5% BF and 0.5% SF resulted in 45%, 27% and 12% improvements in compressive, split tensile and flexural strengths, respectively. The compatibility between the SF and BF resulted in enhanced post-peak flexural behaviour, with 37% improvements in the modulus of elasticity and stiffness. As BF possesses more tensile strength than SF, the use of 1.5% BF and 0.5% SF provided better flexural and ductility properties than the use of SF alone, which could lead to the development of ductile GPC members under dynamic loading conditions.
Does Globalization Reduce Youth Unemployment? Augmented ARDL Approach
Authors: Uğurlu Süleyman
Published: June 2024

While unemployment is a significant issue that has been extensively discussed in economic literature for decades, it is one of the key indicators that governments and firms consider. In fact, reducing unemployment in a country contributes to both increasing social welfare and economic welfare. Fluctuations in unemployment figures during the globalization process have led researchers to prioritize this issue. The objective of this study is to ascertain the impact of globalization on youth unemployment in Türkiye over the period 1988–2021, utilizing the augmented ARDL approach. The KOF Globalization Index, a frequently utilized indicator in the literature, is selected to represent globalization. However, the study is limited by the fact that the most recent data from the KOF index belongs to 2021, and the data on youth unemployment began in 1988. The limited number of studies on the relationship between globalization and youth unemployment in Türkiye constitutes the starting point of this study. The findings of the study indicate that an increase in globalization in the long run decreases youth unemployment in Türkiye. Furthermore, economic growth, inflation, and foreign direct investments also decrease youth unemployment, while an increase in urbanization increases youth unemployment. In addition, if a deviation occurs in the short run, approximately 85% of these deviations disappear in the first period and converge towards the long-run equilibrium.
The Impact of the Localisation of Economic Activity in a Region on Its Budget Expenditures
Authors:   Ural State University of Economics, Kombarov M. A.
Published: June 2024

The search for internal growth points of the regional economy depends on the current foreign economic situation, as well as Russian economic policy. Strengthening the localisation of certain economic activities within a region can trigger the growth of expenditures of its consolidated budget, and, consequently, one of these points. The study aims to identify types of economic activities, the strengthening of localisation of which on the territory of the Ural macroregion contributes to the growth of expenditures of its consolidated budget. The method of regression analysis is applied. According to the obtained results, such types of economic activity classified as sections B–O and S of the Russian Classification of Economic Activities have this characteristic. The tested approach to searching for triggers of growth in expenditures of the subfederal consolidated budget can be applied in other Russian regions.
Оценка вклада сквозных цифровых технологий в развитие внешнеторговой деятельности регионов России
Authors:   Institute of Economics of the Ural Branch of RAS, Krasnykh S. S.
Published: June 2024

Digitalisation is one of the main trends of economic and social development in the 21st century. Digitalisation covers practically all spheres of human and state activity, including foreign trade. The study aims to assess the contribution of digital technologies such as big data, the Internet of Things, artificial intelligence and digital platforms to the development of foreign trade activity in Russian using panel data regression analysis. The research results confirm the significant contribution of digitalisation to the development of foreign trade activity, especially imports, in particular by reducing transaction costs. The findings can be useful for authorities striving to realise the goals of developing the technological sovereignty of Russia.
Mutual Influence of Migration and Global Value Chains: Country Differences
Authors:   Ural Federal University, Nikolaeva Ya. A. , Bedrina E. B. ,   Ural Federal University,   Institute of Economics of the Ural Branch of RAS
Published: June 2024

The article analyses the relationship between migration and global value chains (GVCs) in the modern development of countries. The perspectives of different authors regarding the concept of GVCs are presented. The most significant opportunities arising from an increase in migration flows that can be used to promote value chains are described. Based on statistical data, the dynamics of the GVC participation index for three examined regions was studied.