bluuebunny/crossref_metadata_2025 huggingface dataset:
The Cardiac Neural Crest Cells in Heart Development and Congenital Heart Defects
Authors: Erhardt Shannon , Zheng Mingjie , Zhao Xiaolei , Le Tram P. , Findley Tina O. , Wang Jun
Published: July 2021

The neural crest (NC) is a multipotent and temporarily migratory cell population stemming from the dorsal neural tube during vertebrate embryogenesis. Cardiac neural crest cells (NCCs), a specified subpopulation of the NC, are vital for normal cardiovascular development, as they significantly contribute to the pharyngeal arch arteries, the developing cardiac outflow tract (OFT), cardiac valves, and interventricular septum. Various signaling pathways are shown to orchestrate the proper migration, compaction, and differentiation of cardiac NCCs during cardiovascular development. Any loss or dysregulation of signaling pathways in cardiac NCCs can lead to abnormal cardiovascular development during embryogenesis, resulting in abnormalities categorized as congenital heart defects (CHDs). This review focuses on the contributions of cardiac NCCs to cardiovascular formation, discusses cardiac defects caused by a disruption of various regulatory factors, and summarizes the role of multiple signaling pathways during embryonic development. A better understanding of the cardiac NC and its vast regulatory network will provide a deeper insight into the mechanisms of the associated abnormalities, leading to potential therapeutic advancements.
Fetal Blood Flow and Genetic Mutations in Conotruncal Congenital Heart Disease
Authors: Dyer Laura A. , Rugonyi Sandra
Published: July 2021

In congenital heart disease, the presence of structural defects affects blood flow in the heart and circulation. However, because the fetal circulation bypasses the lungs, fetuses with cyanotic heart defects can survive in utero but need prompt intervention to survive after birth. Tetralogy of Fallot and persistent truncus arteriosus are two of the most significant conotruncal heart defects. In both defects, blood access to the lungs is restricted or non-existent, and babies with these critical conditions need intervention right after birth. While there are known genetic mutations that lead to these critical heart defects, early perturbations in blood flow can independently lead to critical heart defects. In this paper, we start by comparing the fetal circulation with the neonatal and adult circulation, and reviewing how altered fetal blood flow can be used as a diagnostic tool to plan interventions. We then look at known factors that lead to tetralogy of Fallot and persistent truncus arteriosus: namely early perturbations in blood flow and mutations within VEGF-related pathways. The interplay between physical and genetic factors means that any one alteration can cause significant disruptions during development and underscore our need to better understand the effects of both blood flow and flow-responsive genes.
Impact of Renal Replacement Therapy on Mortality in Critically Ill Patients—The Nephrologist’s View within an Interdisciplinary Intensive Care Team
Authors: Klingele Matthias , Baerens Lea
Published: July 2021

Acute kidney injury (AKI) is a common complication in critically ill patients with an incidence of up to 50% in intensive care patients. The mortality of patients with AKI requiring dialysis in the intensive care unit is up to 50%, especially in the context of sepsis. Different approaches have been undertaken to reduce this high mortality by changing modalities and techniques of renal replacement therapy: an early versus a late start of dialysis, high versus low dialysate flows, intermittent versus continuous dialysis, anticoagulation with citrate or heparin, the use of adsorber or special filters in case of sepsis. Although in smaller studies some of these approaches seemed to have a positive impact on the reduction of mortality, in larger studies these effects could not been reproduced. This raises the question of whether there exists any impact of renal replacement therapy on mortality in critically ill patients—beyond an undeniable impact on uremia, hyperkalemia and/or hypervolemia. Indeed, this is one of the essential challenges of a nephrologist within an interdisciplinary intensive care team: according to the individual situation of a critically ill patient the main indication of dialysis has to be identified and all parameters of dialysis have to be individually chosen with respect to the patient’s situation and targeting the main dialysis indication. Such an interdisciplinary and individual approach would probably be able to reduce mortality in critically ill patients with dialysis requiring AKI.
The Effects of Calculated Remnant-Like Particle Cholesterol on Incident Cardiovascular Disease: Insights from a General Chinese Population
Authors: Chen Yanli , Li Guangxiao , Guo Xiaofan , Ouyang Nanxiang , Li Zhao , Ye Ning , Yu Shasha , Yang Hongmei , Sun Yingxian
Published: July 2021

Background: Growing evidence suggests that remnant cholesterol (RC) contributes to residual atherosclerotic cardiovascular disease (ASCVD) risk. However, the cutoff points to treat RC for reducing ASCVD are still unknown. This study aimed to investigate the relationships between RC and combined cardiovascular diseases (CVDs) in a general China cohort, with 11,956 subjects aged ≥ 35 years. Methods: Baseline RC was estimated with the Friedewald formula for 8782 subjects. The outcome was the incidence of combined CVD, including fatal and nonfatal stroke and coronary heart disease (CHD). The Cox proportional hazards model was used to calculate hazard ratios (HRs) with 95% confidence intervals. The restricted cubic spline (RCS) model was used to evaluate the dose–response relationship between continuous RC and the natural log of HRs. Results: After a median follow-up of 4.66 years, 431 CVD events occurred. In the Cox proportional models, participants with a high level of categorial RC had a significantly higher risk for combined CVD (HR: 1.37; 95% CI: 1.07–1.74) and CHD (HR: 1.63; 95% CI: 1.06–2.53), compared to those with a medium level of RC. In the stratification analyses, a high level of RC significantly increased combined CVD risk for subgroups females, age < 65 years, noncurrent smokers, noncurrent drinkers, normal weight, renal dysfunction, and no hyperuricemia. The same trends were found for CHD among subgroups males, age < 65 years, overweight, renal dysfunction, and no hyperuricemia; stroke among subgroup females. In RCS models, a significant linear association between RC and combined CVD and a nonlinear association between RC and CHD resulted. The risk of outcomes was relatively flat until 0.84 mmol/L of RC and increased rapidly afterwards, with an HR of 1.308 (1.102 to 1.553) for combined CVD and 1.411 (1.061 to 1.876) for CHD. Stratified analyses showed a significant nonlinear association between RC and CVD outcomes in the subgroup aged < 65 years or the diabetes subgroup. Conclusions: In this large-scale and long-term follow-up cohort study, participants with higher RC levels had a significantly worse prognosis, especially for the subgroup aged 35–65 years or the diabetes mellitus subgroup.
Minor Allele Frequencies and Molecular Pathways Differences for SNPs Associated with Amyotrophic Lateral Sclerosis in Subjects Participating in the UKBB and 1000 Genomes Project
Authors: D’Antona Salvatore , Bertoli Gloria , Castiglioni Isabella , Cava Claudia
Published: July 2021

Amyotrophic lateral sclerosis (ALS) is a complex disease with a late onset and is characterized by the progressive loss of muscular and respiratory functions. Although recent studies have partially elucidated ALS’s mechanisms, many questions remain such as what the most important molecular pathways involved in ALS are and why there is such a large difference in ALS onset among different populations. In this study, we addressed this issue with a bioinformatics approach, using the United Kingdom Biobank (UKBB) and the European 1000 Genomes Project (1KG) in order to analyze the most ALS-representative single nucleotide polymorphisms (SNPs) that differ for minor allele frequency (MAF) between the United Kingdom population and some European populations including Finnish in Finland, Iberian population in Spain, and Tuscans in Italy. We found 84 SNPs associated with 46 genes that are involved in different pathways including: “Ca2+ activated K+ channels”, “cGMP effects”, ”Nitric oxide stimulates guanylate cyclase”, “Proton/oligopeptide cotransporters”, and “Signaling by MAPK mutants”. In addition, we revealed that 83% of the 84 SNPs can alter transcription factor-motives binding sites of 224 genes implicated in “Regulation of beta-cell development”, “Transcription-al regulation by RUNX3”, “Transcriptional regulation of pluripotent stem cells”, and “FOXO-mediated transcription of cell death genes”. In conclusion, the genes and pathways analyzed could explain the cause of the difference of ALS onset.
Coronary Flow, Left Ventricular Contractile and Heart Rate Reserve in Non-Ischemic Heart Failure
Authors: Daros Clarissa , Ciampi Quirino , Cortigiani Lauro , Gaibazzi Nicola , Rigo Fausto , Wierzbowska-Drabik Karina , Kasprzak Jaroslaw , Dodi Claudio , Villari Bruno , Antonini-Canterin Francesco , Lorenzoni Valentina , Nes Michele , Carpeggiani Clara , Picano Eugenio ,   on behalf of the Stress Echo Study Group of the Italian Society of Echocardiography and Cardiovascular Imaging
Published: July 2021

Background: Left ventricular contractile reserve (LVCR), coronary flow velocity reserve (CFVR), and heart rate reserve (HRR) affect outcome in heart failure (HF). They can be simultaneously measured during dipyridamole stress echocardiography (DSE). Aim: To assess the value of comprehensive DSE in patients with non-ischemic HF. Methods: We evaluated 610 patients with HF, no history of coronary artery disease, and no inducible regional wall motion abnormalities: 270 patients with preserved ejection fraction (≥50%), 146 patients with mid-range ejection fraction (40–49%), and 194 patients with reduced ejection fraction (<40%). All underwent DSE (0.84 mg/kg in 6′) in 7 accredited laboratories. We measured LVCR (abnormal value ≤ 1.1), CFVR in left anterior descending artery (abnormal value: ≤2.0), and HRR (peak/rest heart rate; abnormal value: ≤1.22). All patients were followed up. Results: Abnormal CFVR, LVCR, and HRR occurred in 29%, 45%, and 47% of patients, respectively (p < 0.001). After a median follow-up time of 20 months (interquartile range: 12–32 months), 113 hard events occurred in 105 patients with 41 deaths, 8 myocardial infarctions, 61 admissions for acute HF, and 3 strokes. The annual mortality rates were 0.8% in 200 patients with none abnormal criteria, 1.8% in 184 patients with 1 abnormal criterion, 7.1% in 130 patients with 2 abnormal criteria, 7.5% in 96 patients with 3 abnormal criteria. Conclusions: Abnormal LVCR, CFVR, and HRR were frequent during DSE in non-ischemic HF patients. They target different pathophysiological vulnerabilities (myocardial function, coronary microcirculation, and cardiac autonomic balance) and are useful for outcome prediction.
Dynamic Gelation of Conductive Polymer Nanocomposites Consisting of Poly(3-hexylthiophene) and ZnO Nanowires
Authors: Santos Franceska A. , Christensen Dana J. , Cox Ryan Y. , Schultz Spencer A. , Fernando Raymond H. , Zhang Shanju
Published: July 2021

The sol–gel transition of conductive nanocomposites consisting of poly(3-hexylthiophene) (P3HT) and ZnO nanowires in o-dichlorobenzene (o-DCB) has been investigated rheologically. The physical gelation of P3HT in o-DCB spontaneously occurs upon adding the small amount of ZnO nanowires. The rheological properties of the P3HT/ZnO nanocomposite gels have been systematically studied by varying factors such as polymer concentration, nanowire loading, and temperature. The nanocomposite gel exhibits shear-thinning in the low shear rate range and shear-thickening in the high shear rate range. The elastic storage modulus of the nanocomposite gel gradually increases with gelation time and is consistently independent of frequency at all investigated ranges. The isothermal gelation kinetics has been analyzed by monitoring the storage modulus with gelation time, and the data are well fitted with a first-order rate law. The structural analysis data reveal that the polymer forms the crystalline layer coated on ZnO nanowires. A fringed micelle model is proposed to explain the possible gelation mechanism.
Increasing Mechanical Properties of 3D Printed Samples by Direct Metal Laser Sintering Using Heat Treatment Process
Authors: Živčák Jozef , Nováková-Marcinčínová Ema , Nováková-Marcinčínová Ľudmila , Balint Tomáš , Puškár Michal
Published: July 2021

The paper deals with the evaluation of mechanical properties of 3D-printed samples based on high-strength steel powder system maraging steel using direct metal laser sintering (DMLS), which is currently being put into technical practice. The novelty of this article is that it analyzes mechanical properties of samples both printed and age hardened as well as examining the fracture surfaces. When comparing the manufacturer’s range with our recorded values, samples from Set 1 demonstrated strength ranging from 1110 to ultimate 1140 MPa. Samples from Set 2 showed tensile strength values that were just below average. Our recorded range was from 1920 to ultimate 2000 MPa while the manufacturer reported a range from 1950 to 2150 MPa. The tensile strength was in the range from 841 to ultimate 852 MPa in Set 1, and from 1110 to ultimate 1130 MPa in Set 2.
Effect of Modified Clay on the Growth Dynamics and Physio—Biochemical Response of Newly Hatched Larvae of the Marine Medaka (Oryzias melastigma)
Authors: Zhang Peipei , Song Xiuxian , Zhang Yue , Shen Huihui , Dong Xueyi , Li Jing , Yu Zhiming
Published: July 2021

An outbreak of harmful algal blooms (HABs) often leads to the death of fish and other marine organisms and causes serious losses to human economic activities. Modified clay (MC) technology is an effective way to control HABs. Although the material and preparation process are based on the premise of green and safety, the potential eco-environmental impacts of MC on non-target organisms should still have to receive attention before field applications can occur. Therefore, the effects of one commonly used modified clay, polyaluminum chloride-modified clay (PAC-MC), on the survival, growth, and oxidative stress of the marine medaka (Oryzias melastigma) were studied. The toxicity test results showed that the 96-h median lethal concentration (96-h LC50) of PAC-MC for newly hatched medaka larvae was 5.204 g/L, which was much higher than the concentration used on site (4–10 t/km2). Within the concentration range of PAC-MC used in this experiment (≤2 g/L), the morphology, heart rate, growth, and aluminum content of larvae did not change with the increase in the modified clay concentration. Low concentrations of PAC-MC (≤0.5 g/L) did not significantly affect catalase (CAT) activity, superoxide dismutase (SOD) activity, peroxidase (POD) activity, and the content of malondialdehyde (MDA), but higher concentrations of PAC-MC (such as 2 g/L) caused oxidative damage to the larvae and increased the antioxidant enzyme activity of the larvae. The present study revealed that under an effective dosage for treating harmful algal blooms on site, PAC-MC had no adverse effects on the survival, growth, oxidative stress, and aluminum content of the newly hatched marine medaka, which provides a scientific basis for the field application of modified clay.
Assessing the Impact of Wave–Current Interactions on Storm Surges and Waves during Cold Air Outbreaks in the Northern East China Sea
Authors: Mo Dongxue , Li Jian , Hou Yijun
Published: July 2021

Storm surges and disastrous waves induced by cold air outbreaks, a type of severe weather system, often impact the coastal economic development. Using the Climate Forecast System Reanalysis wind product and the Coupled Ocean–Atmosphere–Wave–Sediment Transport model, we developed a coupled numerical model and applied it to examine the interaction between surface gravity waves and ocean currents during cold air outbreaks in two case studies in the northern East China Sea. The results revealed that wave–current interactions improved the simulation accuracy, especially the water level, as verified by tidal station measurements. We conducted sensitivity experiments to explore the spatiotemporal variation of the impact of wave–current interactions on storm surges and waves in the northern East China Sea, away from the coastline. The wave-induced surge (up to 0.4 m) and the wave-induced current (up to 0.5 m/s) were found to be related to the difference between wave direction and current direction. The significant wave height difference (up to 0.5 m) was sensitive to the storm surge nearshore and sensitive to the current field offshore, while the mean wave direction change (up to 40°) was more sensitive to the current field than to the storm surge. Additionally, the wave–current interaction regulated the momentum balance and wave action balance, respectively. By comparison, the momentum residuals of pressure gradient, Coriolis force, Coriolis–Stokes force, and bottom stress, which were pronounced in different areas, were modulated more significantly by the wave effect than other terms. The dominant mechanisms of wave–current interactions on waves included the current-induced modification of energy generation caused by wind input, the current-induced modification of energy dissipation caused by whitecapping, and the current-induced wave advection.
Observer-Based Autopilot Heading Finite-Time Control Design for Intelligent Ship with Prescribed Performance
Authors: Zhu Liyan , Li Tieshan
Published: July 2021

Traffic engineering control is a major challenge in marine transportation. Cost efficiency and high performance demand advanced technologies for the ship control systems. This paper develops an autopilot heading control scheme based on a fuzzy state observer for an intelligent ship on this subject to track the prescribed function while calling for performance limitation and order execution time. A fuzzy logic system (FLS) is adopted to approximate the unknown uncertainties caused by the changes in water depth, wind, wave, ship loading, and speed in navigation. State observer is required to obtain unknown yaw rate. By adopting performance function and tracking error transformation techniques, the heading tracking error can converge to prescribed performance bounds. Taking settling time into account, the finite-time adaptive prescribed performance control algorithm can save more resources effectively. Based on the Lyapunov stability theory, the observer-based adaptive fuzzy control approach does not cause any unbounded signal, the system remains stable. Meanwhile, the autopilot heading control system with an unknown yaw rate and constraint state can benefit from the given design.
Investigations into Chemical Components from Monascus purpureus with Photoprotective and Anti-Melanogenic Activities
Authors: Wu Ho-Cheng , Chen Yih-Fung , Cheng Ming-Jen , Wu Ming-Der , Chen Yen-Lin , Chang Hsun-Shuo
Published: July 2021

Monascus species are asexually or sexually reproduced homothallic fungi that can produce a red colorant, specifically the so-called red yeast rice or Anka, which is used as a food ingredient in Asia. Traditional experiences of using Monascus for treating indigestion, enhancing blood circulation, and health remedies motivate us to investigate and repurpose Monascus-fermented products. Here, two new 5H-cyclopenta[c]pyridine type azaphilones, 5S,6S-monaspurpyridine A (1) and 5R,6R-monaspurpyridine A (2), two new xanthonoids, monasxanthones A and B (3 and 4), one new naphthalenone, monasnaphthalenone (5), and one new azaphilone, monapurpurin (6), along with two known compounds were isolated from the 70% EtOH extract of a citrinin-free domesticated strain M. purpureus BCRC 38110. The phytochemical properties of the xanthonoid and naphthalenone components were first identified from Monascus sp. differently from the representative ingredients of polyketide-derived azaphilones. UVB-induced cell viability loss and reactive oxygen species (ROS) overproduction in human keratinocytes were attenuated by monascuspirolide B (7) and ergosterol peroxide (8), indicating their photoprotective potentials. Ergosterol peroxide (8) decreased the melanin contents and tyrosinase activities of mouse melanocytes, depending on the concentration, suggesting their anti-melanogenic effects. In conclusion, six new and two known compounds were isolated from M. purpureus BCRC 38110, and two of them exhibited dermal protective activities. The results revealed the novel potential of M. purpureus for developing natural cosmeceutics against skin photoaging.
LAG-3 Expression Predicts Outcome in Stage II Colon Cancer
Authors: Rhyner Agocs Gaëlle , Assarzadegan Naziheh , Kirsch Richard , Dawson Heather , Galván José A. , Lugli Alessandro , Zlobec Inti , Berger Martin D.
Published: July 2021

Introduction: LAG-3 is an inhibitory immune checkpoint molecule that suppresses T cell activation and inflammatory cytokine secretion. T cell density in the tumor microenvironment of colon cancer plays an important role in the host’s immunosurveillance. We therefore hypothesized that LAG-3 expression on tumor-infiltrating lymphocytes (TILs) predicts outcome in patients with stage II colon cancer. Patients and Methods: Immunohistochemical staining for LAG-3 was performed on tissue microarrays (TMAs) of formalin-fixed paraffin-embedded tissue from 142 stage II colon cancer patients. LAG-3 expression was assessed in TILs within both the tumor front and tumor center and scored as either positive or negative. The primary endpoint was disease-free survival (DFS). Results: In patients diagnosed with stage II colon cancer, the presence of LAG-3 expression on TILs was significantly associated with better 5-year DFS (HR 0.34, 95% CI 0.14–0.80, p = 0.009). The effect on DFS was mainly due to LAG-3-positive TILs in the tumor front (HR 0.33, 95% CI 0.13–0.82, p = 0.012). Conclusion: Assessment of LAG-3 might help to predict outcomes in patients with stage II colon cancer and potentially identify those patients who might benefit from adjuvant chemotherapy. Therefore, LAG-3 may serve as a prognostic biomarker in stage II colon cancer.
Genetic Association of the Functional WDR4 Gene in Male Fertility
Authors: Wang Yu-Jia , Mugiyanto Eko , Peng Yun-Ting , Huang Wan-Chen , Chou Wan-Hsuan , Lee Chi-Chiu , Wang Yu-Shiuan , Irham Lalu Muhammad , Perwitasari Dyah Aryani , Hsu Ming-I , Chang Wei-Chiao
Published: July 2021

Infertility is one of the important problems in the modern world. Male infertility is characterized by several clinical manifestations, including low sperm production (oligozoospermia), reduced sperm motility (asthenozoospermia), and abnormal sperm morphology (teratozoospermia). WDR4, known as Wuho, controls fertility in Drosophila. However, it is unclear whether WDR4 is associated with clinical manifestations of male fertility in human. Here, we attempted to determine the physiological functions of WDR4 gene. Two cohorts were applied to address this question. The first cohort was the general population from Taiwan Biobank. Genomic profiles from 68,948 individuals and 87 common physiological traits were applied for phenome-wide association studies (PheWAS). The second cohort comprised patients with male infertility from Wan Fang Hospital, Taipei Medical University. In total, 81 male participants were recruited for the genetic association study. Clinical records including gender, age, total testosterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), total sperm number, sperm motility, and sperm morphology were collected. In the first cohort, results from PheWAS exhibited no associations between WDR4 genetic variants and 87 common physiological traits. In the second cohort, a total of four tagging single-nucleotide polymorphisms (tSNPs) from WDR4 gene (rs2298666, rs465663, rs2248490, and rs3746939) were selected for genotyping. We found that SNP rs465663 solely associated with asthenozoospermia. Functional annotations through the GTEx portal revealed the correlation between TT or TC genotype and low expression of WDR4. Furthermore, we used mouse embryonic fibroblasts cells from mwdr4 heterozygous (+/‒) mice for functional validation by western blotting. Indeed, low expression of WDR4 contributed to ROS-induced DNA fragmentation. In conclusion, our results suggest a critical role of WDR4 gene variant as well as protein expression in asthenozoospermia.
Do Terror Attacks Affect the Euro? Evidence from the 21st Century
Authors: Markoulis Stelios
Published: July 2021

The objective of this paper is to examine whether terror attacks that took place in the Eurozone in the 21st century had a significant effect on the price of the Euro. Its novelty is twofold: it is the first study that assesses the impact of such events on the price of the Euro and employs a relatively large number of these events. The event-study methodology is used to deduce whether, after a terror event, the value of the Euro declines vs. other major currencies. We found that it does not, since following such an event, the decline was seldom over 0.5%. We also found, however, evidence of some diversion to safe-haven currencies, such as the Swiss Franc. Regression analysis revealed that factors such as the ‘number of attacks’, the ‘type of target’ and the ‘type of attack’, but not the number of casualties, affected the price of the Euro.
Determinants of Insurance Penetration in West African Countries: A Panel Auto Regressive Distributed Lag Approach
Authors: Olarewaju Odunayo , Msomi Thabiso
Published: July 2021

This study analyses the long- and short-term dynamics of the determinants of insurance penetration for the period 1999Q1 to 2019Q4 in 15 West African countries. The panel auto regressive distributed lag model was used on the quarterly data gathered. A cointegrating and short-run momentous connection was discovered between insurance penetration along with the independent variables, which were education, productivity, dependency, inflation and income. The error correction term’s significance and negative sign demonstrate that all variables are heading towards long-run equilibrium at a moderate speed of 56.4%. This further affirms that education, productivity, dependency, inflation and income determine insurance penetration in West Africa in the long run. In addition, the short-run causality revealed that all the pairs of regressors could jointly cause insurance penetration. The findings of this study recommend that the economy-wide policies by the government and the regulators of insurance markets in these economies should be informed by these significant factors. The restructuring of the education sector to ensure finance-related modules cut across every faculty in the higher education sector is also recommended. Furthermore, Bancassurance is also recommended to boost the easy penetration of the insurance sector using the relationship with the banking sector as a pathway.
Spatiotemporal Dynamics of Green Infrastructure in an Agricultural Peri-Urban Area: A Case Study of Baisha District in Zhengzhou, China
Authors: Xia Hua , Ge Shidong , Zhang Xinyu , Kim Gunwoo , Lei Yakai , Liu Yang
Published: July 2021

Quantifying the dynamics of green infrastructure (GI) in agricultural peri-urban areas is of great significance to the regional ecological security, food security, and the sustainable development of urban integration. Based on remote sensing images, this study aims to provide a spatiotemporal dynamic assessment of the GI in Baisha District from 2007 to 2018 to improve the layout of GI and planning policies from the perspective of ecological security and food security. Research methods include landscape pattern indices, spatial autocorrelations, and grid analyses in this case study. The results suggest that ensuring the dominant position of farmland is critical to maintaining the composition and connectivity of the overall GI. The recreation, inheritance of farming culture, and ecosystem service functions of farmland should be improved to meet the growing needs of urban residents. GI includes the farmland, greenspace, and wetland on both sides of the Jialu River that should be retained and restored as much as possible to protect natural ecological processes. Simultaneously, construction of important urban facilities and residential areas in flooded areas should be banned. A part of the evenly distributed large greenspace patches should be moved to both sides of the Jialu River to increase the agglomeration effect of GI. Optimization measures in this case study also offer a perspective for other agricultural peri-urban areas that have experienced similar urbanization.
Interaction between Land Financing Strategy and the Implementation Deviation of Local Governments’ Cultivated Land Protection Policy in China
Authors: Zhang Xupeng , Chen Danling , Lu Xinhai , Tang Yifeng , Jiang Bin
Published: July 2021

The deviation of implementation of China’s cultivated land protection policy is the core problem urgently needing to be solved in the process of protecting the country’s cultivated land. This paper aims to explain the universality of this implementation deviation from the perspective of the spatial interaction of fiscal land strategies. Based on the data of 30 provinces in China from 2000 to 2015, the spatial Durbin model is used to validate the corresponding theoretical hypothesis. The results show that: (1) At the national or regional level, the given local government’s behavior with regard to land conveyance and land-orientation investment will aggravate implementation deviations of the cultivated land protection policy in the local area. (2) Land conveyance and land-orientation investment behaviors cause a spatial spillover effect. As a result, these behaviors not only exacerbate the implementation deviation of the cultivated land protection policy in the local area, but also exacerbate this deviation in adjacent areas. (3) The spatial spillover effects of land conveyance and land-orientation investment strategies in the eastern, central and western regions of China show marked differences. However, in general, compared with the land transfer strategy, the spatial interactions of the land-orientation investment strategy represent the more important factor that gives rise to the widespread deviation in the implementation of the cultivated land protection policy. (4) The transformation of the performance appraisal system can help to weaken the interactive behavior of the land financing strategy. This can, in turn, not only alleviate the deviation degree of the implementation of the local cultivated land protection policy, but also the deviation degree of the implementation of the latter in adjacent areas.
Supplementing Closed Ecological Life Support Systems with In-Situ Resources on the Moon
Authors: Ellery Alex
Published: July 2021

In this review, I explore a broad-based view of technologies for supporting human activities on the Moon and, where appropriate, Mars. Primarily, I assess the state of life support systems technology beginning with physicochemical processes, waste processing, bioregenerative methods, food production systems and the robotics and advanced biological technologies that support the latter. We observe that the Moon possesses in-situ resources but that these resources are of limited value in closed ecological life support systems (CELSS)—indeed, CELSS technology is most mature in recycling water and oxygen, the two resources that are abundant on the Moon. This places a premium on developing CELSS that recycle other elements that are rarified on the Moon including C and N in particular but also other elements such as P, S and K which might be challenging to extract from local resources. Although we focus on closed loop ecological life support systems, we also consider related technologies that involve the application of biological organisms to bioregenerative medical technologies and bioregenerative approaches to industrial activity on the Moon as potential future developments.
Biochemical Correlates of Video Game Use: From Physiology to Pathology. A Narrative Review
Authors: Carpita Barbara , Muti Dario , Nardi Benedetta , Benedetti Francesca , Cappelli Andrea , Cremone Ivan Mirko , Carmassi Claudia , Dell’Osso Liliana
Published: July 2021

In the last few decades, video game playing progressively became a widespread activity for many people, in childhood as well in adulthood. An increasing amount of literature has focused on pathological and non-pathological correlates of video game playing, with specific attention towards Internet Gaming Disorder (IGD). While many neurobiological studies in this field were based on neuroimaging, highlighting structural and functional brain changes among video game users, only a limited number of studies investigated the presence of biochemical correlates of video gaming. The present work aims to summarize and review the available literature about biochemical changes linked to video game use in IGD patients as well as non-pathological users, and the differences in between. Results may shed light on risks and benefits of video games, providing directions for further research on IGD treatment and, on other hand, on the potential role of video games in therapeutic or preventive protocols for specific conditions.
Dual-Laser PBF-LB Processing of a High-Performance Maraging Tool Steel FeNiCoMoVTiAl
Authors: Graf Gregor , Nouri Niki , Dietrich Stefan , Zanger Frederik , Schulze Volker
Published: July 2021

As part of an international research project (HiPTSLAM), the development and holistic processing of high-performance tool steels for AM is a promising topic regarding the acceptance of the laser powder bed fusion (PBF-LB) technology for functionally optimized die, forming and cutting tools. In a previous work, the newly developed maraging tool steel FeNiCoMoVTiAl was qualified to be processed by laser powder bed fusion (PBF-LB) with a material density of more than 99.9% using a suitable parameter set. To exploit further optimization potential, the influence of dual-laser processing strategies on the material structure and the resulting mechanical properties was investigated. After an initial calibration procedure, the build data were modified so that both lasers could be aligned to the same scanning track with a defined offset. A variation of the laser-based post-heating parameters enabled specific in-situ modifications of the thermal gradients compared to standard single-laser scanning strategies, leading to corresponding property changes in the produced material structure. An increase in microhardness of up to 15% was thus obtained from 411 HV up to 471 HV. The results of the investigation can be used to derive cross-material optimization potential to produce functionally graded high-performance components on PBF-LB systems with synchronized multi-laser technology.
Nano-Porous-Silicon Powder as an Environmental Friend
Authors: Nabil Marwa , Mahmoud Kamal Reyad , Nomier Raghda , El-Maghraby El-Maghraby , Motaweh Hussien
Published: July 2021

Nano-porous silicon (NPS) powder synthesis is performed by means of a combination of the ultra-sonication technique and the alkali chemical etching process, starting with a commercial silicon powder. Various characterization techniques {X-ray powder diffraction, transmission electron microscopy, Fourier Transform Infrared spectrum, and positron annihilation lifetime spectroscopy} are used for the description of the product’s properties. The NPS product is a new environmentally friendly material used as an adsorbent agent for the acidic azo-dye, Congo red dye. The structural and free volume changes in NPS powder are probed using positron annihilation lifetime (PALS) and positron annihilation Doppler broadening (PADB) techniques. In addition, the mean free volume (VF), as well as fractional free volume (Fv), are also studied via the PALS results. Additionally, the PADB provides a clear relationship between the core and valence electrons changes, and, in addition, the number of defect types present in the synthesized samples. The most effective parameter that affects the dye removal process is the contact time value; the best time for dye removal is 5 min. Additionally, the best value of the CR adsorption capacity by NPS powder is 2665.3 mg/g at 100 mg/L as the initial CR concentration, with an adsorption time of 30 min, without no impact from temperature and pH. So, 5 min is the enough time for the elimination of 82.12% of the 30 mg/L initial concentration of CR. This study expresses the new discovery of a cheap and safe material, in addition to being environmentally friendly, without resorting to any chemical additives or heat treatments.
Preparation of W-C-Co Composite Micropowder with Spherical Shaped Particles Using Plasma Technologies
Authors: Samokhin Andrey , Alekseev Nikolay , Astashov Aleksey , Dorofeev Aleksey , Fadeev Andrey , Sinayskiy Mikhail , Kalashnikov Yulian
Published: July 2021

The possibility of obtaining composite micropowders of the W-C-Co system with a spherical particle shape having a submicron/nanoscale internal structure was experimentally confirmed. In the course of work carried out, W-C-Co system nanopowders with the average particle size of approximately 50 nm were produced by plasma-chemical synthesis. This method resulted in the uniform distribution of W, Co and C among the nanoparticles of the powder in the nanometer scale range. Dense microgranules with an average size of 40 microns were obtained from the nanopowders by spray drying. The spherical micropowders with an average particle size of 20 microns were received as a result of plasma treatment of 25.36 microns microgranule fraction. The spherical particles obtained in the experiments had a predominantly dense microstructure and had no internal cavities. The influence of plasma treatment process parameters on dispersity, phase, and chemical composition of spherical micropowders and powder particles microstructure has been established.
Influence of High Temperature Curing and Surface Humidity on the Tensile Strength of UHPC
Authors: Kalthoff Matthias , Raupach Michael , Matschei Thomas
Published: July 2021

The objective of this study is an investigation of the different parameters that influence the tensile strength of ultra-high performance concrete (UHPC). Apart from the shrinkage and stiffness, the tensile strength is an important parameter for the design of crack-free concrete elements, e.g., in machine tool construction. One focus of our work is the influence of concrete curing and the great impact of the mechanical and physical characteristics of hydrated UHPC. For this reason, different curing regimes were investigated. The results show that even after heat treatment or autoclaving, the centric tensile strength of UHPC specimens is strongly influenced by the surrounding ambient humidity. Test specimens that were stored under water after a heat treatment or autoclaving and were still wet during the test had the highest tensile strengths. Storage at 20 °C and 65% relative humidity (rH), however, results in a 25% reduction in tensile strength. Alternating storage between water storage at 20 °C water and storage at 65% rH can also reduce the tensile strength dramatically by up to 70%. In particular, samples that were stored at 65% rH right before testing had very low tensile strengths. Surprisingly, the initially low tensile strength of previously dry stored UHPC can be restored by subsequent water storage. In the absence of any microstructural defects, e.g., microcracks, a possible explanation for this phenomenon can be the stress differences due to a humidity gradient between the core and surfaces and shrinkage combined with a continued reaction of the unhydrated binders of the UHPC.
Influence of Fluorine-Containing Monomer Content on the Hydrophobic and Transparent Properties of Nanohybrid Silica Polyacrylate Coating Materials
Authors: Huang Chih-Ming , Wang Her-Yung , Fang Sing-Yuan , Yang Wein-Duo
Published: July 2021

Nanosilica-modified, fluorine-containing polyacrylate hybrid coating materials, consisting of dodecafluoroheptyl methacrylate (DFMA), methyl methacrylate (MMA), 2-ethyl hexyl acrylate (2-EHA), 3-(trimethoxysilyl) propyl methacrylate (KH-570), and tetraethylorthosilicate (TEOS), are synthesized successfully by free radical polymerization and the sol–gel process. It is revealed that the content of the fluorine-containing polyacrylate hybrid coating materials from DFMA monomers significantly improves the properties of the films. The polyacrylate coating film prepared with a weight ratio of DFMA/MMA at 1:5 exhibits the largest water contact angle of 105.4°, which demonstrates that DFMA can effectively improve the hydrophobicity of the coating film. Moreover, the silicon coupling agent (KH-570) is used to graft silica with acrylate. Spherical in shape, the surface morphology of the nanohybrid film exhibits a core–shell structure, which increases the surface roughness and enhances the hydrophobic properties. The as-prepared fluorine-containing nanohybrid silica polyacrylate film possesses a high transmittance of 89–97% in the visible light region, indicating its potential as a very attractive solution in many practical areas.
Characteristics of Impulse Carburization LPC Process
Authors: Filip Ryszard , Ochał Kamil , Gancarczyk Kamil , Nowak Wojciech Jerzy , Kościelniak Barbara , Wierzba Bartek
Published: July 2021

In the present work, Pyrowear53 steel was subjected to the impulse carburizing LPC process. After carburation, the material was quenched and tempered. Postprocessing analyses included the measurement of hardness, carbon content, residual austenite, and residual stresses. The results revealed that the thermochemical treatment resulted in the formation of an approximately 1200 µm wide carburized layer. The results of hardness, carbon content, and residual austenite measurement showed a continuous gradient (drop) in the measured values within the carburized layer. However, the results of residual stresses revealed the existence of a local extremum, namely, a zone with higher compressive stresses at the depth between 600 and 1000 µm. This was explained by a different temperature for initiation of martensite transformation as a function of carbon content. This difference resulted in the occurrence of two martensite expansion fronts at two different depths, resulting in an increase in compressive stresses at the noted depth range. Moreover, it was concluded that this region was present for material containing between 0.8 and 0.4 wt% carbon for Pyrowear53.
Comprehensive Assessment from Optimum Biodiesel Yield to Combustion Characteristics of Light Duty Diesel Engine Fueled with Palm Kernel Oil Biodiesel and Fuel Additives
Authors: Sabapathy Senthur Prabu , Ammasi Asokan Morappur , Khalife Esmail , Kaveh Mohammad , Szymanek Mariusz , Kuruvakkattu Reghu Gokul , Sabapathy Prathiba
Published: July 2021

Biodiesel is considered as a key prospective renewable energy source in India. Hence, a study was carried out for the improvement of palm kernel oil biodiesel production using a transesterification process at different molar ratios. This study comprehensively examined all aspects of biodiesel from optimum production to the effect of additives on its combustion behavior. The optimum yield condition was validated with the MINITAB-17 software and analyzed using the Taguchi method. Two different additives, 5% diethyl ether (DEE) and 2000 ppm Butylated hydroxyltoluene (BHT), were also experimented. Engine experiments were conducted at constant speed (1500 rpm) and five different engine loads (0, 25, 50, 75 and 100%) on a single-cylinder direct injection diesel engine. Heat release rate, brake specific fuel consumption, brake thermal efficiency, engine emissions, such as CO, HC, NOx, and smoke opacity were analyzed. The maximum palm kernel oil (PKO) biodiesel yields, obtained at 55 °C, for the KOH and NaOH catalysts were 86.69% and 75.21% at the molar ratio of 6:1. B20BHT combustion showed 4.6% higher brake thermal efficiency (BTE). NOx emission was reduced by 19.4%, compared to the diesel fuel values. DEE resulted in higher CO and HC emissions compared to diesel fuel values by 39.2% and 7.6%, respectively, whereas smoke emission was improved by 11.5%.
Enhanced Storage Performance of PANI and PANI/Graphene Composites Synthesized in Protic Ionic Liquids
Authors: Al-Zohbi Fatima , Ghamouss Fouad , Schmaltz Bruno , Abarbri Mohamed , Zaghrioui Mustapha , Tran-Van François
Published: July 2021

Polyaniline (PANI) was synthesized using oxidative polymerization in a mixture of water with pyrrolidinium hydrogen sulfate [Pyrr][HSO4], which is a protic ionic liquid PIL. The obtained PANI (PANI/PIL) was compared with conventional PANI (PANI/HCl and PANI/HSO4) in terms of their morphological, structural, and storage properties. The results demonstrate that the addition of this PIL to a polymerization medium leads to a fiber-like morphology, instead of a spherical-like morphology, of PANI/HSO4 or an agglomerated morphology of PANI/HCl. In addition, PAN/PIL exhibits an improvement of the charge transfer kinetic and storage capability in H2SO4 1 mol·L−1, compared to PANI/HCl. The combination of PANI/PIL and graphene oxide (GO), on the other hand, was investigated by optimizing the PANI/GO weight ratio to achieve the nanocomposite material with the best performance. Our results indicate that the PANI/PIL/GO containing 16 wt% of GO material exhibits a high performance and stability (223 F·g−1 at 10 A·g−1 in H2SO4 1 mol·L−1, 4.9 Wh·Kg−1, and 3700 W·Kg−1 @ 10 A·g−1). The obtained results highlight the beneficial role of PIL in building PANI and PANI/GO nanocomposites with excellent performances for supercapacitor applications.
A Comparison Study on the Strengthening and Toughening Mechanism between Cu-Bearing Age-Hardening Steel and NiCrMoV Steel
Authors: Luo Xiaobing , Xiang Chongchen , Chai Feng , Wang Zijian , Zhang Zhengyan , Ding Hanlin
Published: July 2021

Cu-bearing age-hardening steel has significant potential in shipbuilding applications due to its excellent weldability as compared to conventional NiCrMoV steel. Not much research has been carried out to analyze the differences in the mechanisms of strength and toughness between Cu-bearing age-hardening and NiCrMoV steel. Both steels were heat treated under the same conditions: they were austenized at 900 °C and then quenched to room temperature, followed by tempering at 630 °C for 2 h. The uniaxial tensile test reveals that the Cu-bearing age-hardening steel exhibits relatively lower strength but larger plasticity than NiCrMoV steel. The lower contents of Carbon and other alloying elements is one of possible reasons for these differences in mechanical properties. Transmission Electron Microscope observations show that two types of precipitates, Cr carbides and Cu-rich particles, exist in tempered Cu-bearing age-hardening steel. Cu-rich particles with sizes of 20–40 nm can inhibit the dislocation motion during deformation, which then results in dislocation pile ups and multiplication; this makes up the strength loss of Cu-bearing age-hardening steel and simultaneously improves its plasticity.