bluuebunny/crossref_metadata_2025 huggingface dataset:
A Challenging Case of Neurodegenerative type of Central Nervous System Langerhans Cell Histiocytosis
Authors: Navalkele Pournima , Guzman Miguel , Mercier Philippe
Published: January 2024

Neurodegenerative (ND) type of Central Nervous System (CNS) Langerhans
Cell Histiocytosis (LCH) is a very rare disease. We report a case of a
pregnant teenager found to have central diabetes insipidus and T2 FLAIR
contrast-enhancing lesions on MRI brain. Extensive workup including
brain biopsy showed inflammation and concern for LCH. Progressive
neurological symptoms prompted the start of low-dose cytosine
arabinoside chemotherapy. Her symptoms and serial MRI brain scans showed
a complete tumor response to the chemotherapy. Off-therapy tumor
recurrence prompted the use of MAPK (mitogen-activated protein kinase)
pathway agent Trametinib with good response.
Do Covid-19 patients needing ICU admission have worse 6 months follow up outcomes when compared with hospitalized non-ICU patients? A prospective cohort study
Authors: yildirim suleyman , Susam Seher , Cimen Pınar , Yapicioglu Sena , Sunecli Onur , Ediboglu Özlem , Kirakli Cenk
Published: January 2024

Objectives Long-term outcomes of COVID-19 patients who discharge ICU are
unclear. We investigated the effect of COVID-19 on lung structure,
pulmonary functional, exercise capacity and quality of life in patients
discharge from ICU and medical ward. Methods A prospective single-centre
study conducted in PCR confirmed COVID-19 patients who has been
discharged from University of Health Sciences, Dr. Suat Seren Chest
Disease and Thoracic Surgery Teaching and Research Hospital between 15
January and 5 March 2021. Patients who followed up for more than 48
hours in ICU and more than 72 hours in medical ward were included the
study. Computed tomography scores, pulmonary functional tests (PFT),
6-min walking distance and health related quality of life by SF-36 were
compared between ICU and medical ward patients at 6 months after
discharge. Results Seventy patients were included final analyses and 31
of them discharged from ICU. ICU patients had higher CT scores than
non-ICU patients at admission (17 vs 11) and follow up visit (6 vs 0).
Two-three of ICU patients had at least one abnormal finding at control
CT. Advanced age (OR 1.08, 95% CI 1.02-1.15) and higher CT score at
admission (OR 1.13, 95% CI 1.01-1.27) were risk factors for having
radiological abnormalities at control CT. 90% of the patients
discharged from the ICU had at least one persistent symptom. Conclusion
A number of COVID-19 survivors could not fully recover after 6 months of
hospital discharge. COVID-19 survivor needs to support therapies at
recovery phase of the disease.
Mechanism of polarized electromagnetic force generated by electromagnetic synergy on migration mode of droplets
Authors: Guo Kai , Liu Xiaoya , Lü Yuling , Ling Xiao , Zhao Jie
Published: January 2024

The device of oil-water separation enhanced by electromagnetic synergy
could potentially play a pivotal role in realizing the green oil
gathering and transportation pretreatment in the future. In this paper,
the high-speed microscopic experiment shows that the migration mode of a
single droplet under the action of the polarized electromagnetic force
is not consistent with the previous theoretical analysis. Theoretical
analysis shows that the longitudinal migration mode of a droplet under
the polarized electromagnetic force is oscillatory displacement.
However, the experimental results show that the longitudinal movement
direction of a droplet remains unchanged, and there is no oscillatory
displacement. Moreover, the effect of the polarized electromagnetic
force on a droplet is reflected in the form of enhancing longitudinal
displacement. In addition, by solving the motion equation, the velocity
difference of the droplet after a period is obtained, and the influence
mechanism of the polarized electromagnetic force is discussed.
The gliptin: one type of potential drug for the treatment of fibrotic diseases
Authors: liang zhongyao
Published: January 2024

Fibrosis is a common terminal state of many chronic diseases and there
are few effective treatments at present. The gliptin is a class of DPP4
inhibitors used in the treatment of type 2 diabetes. At present, many
studies show that it may have the effect of inhibiting fibrosis. In
order to explore the role of the gliptin in different fibrotic diseases,
we searched the related literature about the fibrotic diseases and the
gliptin. In our review, we found that the gliptin can inhibit the
fibrotic process through a variety of mechanisms. The evidence for the
inhibition of atherosclerosis by the gliptin is strong. For pulmonary,
renal and cardiac fibrosis, more clinical studies are needed to support
it. However, there is no benefit in the treatment of liver fibrosis with
the gliptin. To sum up, it is true that the gliptin has the
broad-spectrum anti-fibrotic effects.
Evaluation of bioaccumulation pattern of toxic heavy metals in commonly consumed fishes from East Kolkata Wetlands, a designated Ramsar site of India
Authors: DUTTA JOYSTU , Thakur Tarun , Zaman Sufia , Mitra Abhijit
Published: January 2024

Waste water fed pisciculture is nowadays a feature that is common in
aquaculture belts across the globe. East Kolkata Wetlands (EKW) is a
nature’s wonder where waste water fed natural aquaculture belt is active
for more than 70 years now and is efficiently operating as a natural
waste management system.The peri urban wetland is also a site of
international importance and is listed in Ramsar. Field and lab-based
investigations were carried out with three commonly edible carp variety
of fishes such as Rohu (Labeorohita), Catla(Catlacatla) and Nile Tilapia
(Oreochromisniloticus) collected from ponds (bheries) of the wetland
located on the eastern fringes of Kolkata, India. The lab-based analysis
reveals the presence of many toxic heavy metals like Lead (Pb), Cadmium
(Cd), Chromium (Cr), and Mercury (Hg) in the samples with the seasonal
order of accumulation being monsoon >post-monsoon
>winter >pre-monsoon in the successive years
2016, 2017 and 2018. The order in which toxic metals are bio-accumulated
in fishes is Tilapia>Rohu>Catla.
Bioaccumulation of toxic heavy metals shows the trend
Pb>Cd>Cr>Hg across all the
seasons and years.The ambient media is also investigated to better
understand the bioaccumulation pattern at different trophic levels of
the ecosystem. Water and sediments were analyzed to evaluate the
contamination of toxic heavy metals from point as well as non-point
sources. In this study, the observed bioaccumulation pattern of the
toxic heavy metals in one of the fragile ecosystems raises questions of
environmental management. This study further raises considerable doubt
on environmental safety of daily consumed food items.
Sialoblastoma: A historical review of diagnosis and management
Authors: Costa Pamela , Nasr Mariana , Goncalves Pedro Henrique , Ferman Sima , Freitas Andressa de , Santos Izabella
Published: January 2024

The Sialoblastoma is a rare malignant tumor of the epithelial cells of
the salivary glands, with less than 100 cases reported. Its main
location is in the parotid gland, but it may affect other salivary
glands. The diagnose should be investigated in cases of a congenital
tumor in the topography of these salivary glands and may be confirmed by
open biopsy, or after complete excision. Due to rarity of the disease,
there is no consensus for the conduct in the literature, but surgical
treatment shown better outcomes. The adjuvant treatment with
chemotherapy may be feasible to advanced metastatic cases.
Theoretical Study of the Reactions of Nitrogen Dioxide with Dimethyl Ether and 1,2-Ethanediol
Authors: Shi Gai , Song Jinou
Published: January 2024

The reactions of nitrogen dioxide (NO2) with dimethyl ether (CH3OCH3)
and 1,2-ethanediol((CH2OH)2) were characterized at a reliable
computational level with large basis sets. The results showed that the
channel of hydrogen abstraction from -CH3 group was predominant for the
CH3OCH3 + NO2 reaction and the channel of hydrogen abstraction from
–CH2 group was predominant for the (CH2OH)2 + NO2 reaction. The
reaction rate coefficients were calculated at the canonical variational
transition state theory (CVT) with the small curvature tunneling (SCT)
correction. The effects of reactant complexes on barrier heights and
tunneling factors were considered.
Fatty acid composition of Eucommia rubber particles, content and molecular weight distribution of Eu-rubber in Eucommia ulmoides leaves and samaras
Authors: Liu Ping , Qin Li-Jun , Yuan Ting , Yang Zheng-Wei , Zhao De-Gang
Published: January 2024

The results from optical microscope and scanning electron microscope
found that small rubber particles (SRPs) (1~4 μm) and
medium rubber particles (MRPs) (4~7 μm) respectively
from E. ulmoides leaves and samaras (collected in October, 2019)
accounted for 39%, 53% and 38%, 34%, while the content of the large
rubber particles (LRPs) (7~11 μm) were 23% and
13%respectively. Analysis of FAs composition of EuPRs from EuPRs
extracted from leaf and samara by GC-MS showed that there was a
significant difference of fatty acid composition in different E.
ulmoides organs. Among the 35 kinds of FAs determined, three kinds of
saturated fatty acids (SFAs) including eleven carbonic (C11:0), thirteen
carbonic (C13:0), arachidic acids (C20:0) were uniquely detected in leaf
rubber particles (LeRPs), while γ-linolenic acid (C18:3n6) was
exclusively found in samara rubber particles (SaRPs) although in very
low content, which indicated the γ-linolenic acid might be a constituent
of NRCs of rubber chian in SaRPs. Notably, the seven most important FAs
in SaRPs accounted for 95.19% of the total FAs, while the counterparts
accounted for 89.40%. Synchronously, the molecular weight (Mw) and
molecular weight distribution (MWD) were also be analyzed by GPC and the
resulted that there were 5 peaks in the mass distribution of rubber
molecules in Eucommia rubber particles in leaves, namely P1, P2, P3, P4
and P5, while the samara showed two to three peaks (P1, P2 or/and P3).
The D value (MWD, D = Mw/Mn) of gutta-percha from E. ulmoides leaves and
samaras were 6.76 and 40.61 respectively, which there was a larger
molecular weight difference of gutta-percha molecules from samara EuRPs
while there was a smaller one in gutta-percha molecules from leaf EuRPs.
A-stable, explicit formula for solving stiff ordinary differential equations in science and engineering
Authors: Chang Shuenn-Yih
Published: January 2024

It is generally recognized that there is no explicit method that can be
A-stable among the linear multi-step methods. However, a novel
problem-dependent method is shown to be one-step, explicit, A-stable and
second order accurate. To emphasize that the new method can possess the
repelling properties of the A-stability and explicit implementation, a
variety of first order stiff problems are solved and the results are
consistent with the analytical predictions. Since A-stability and second
order accuracy allow the use of a large step size and explicit
implementation implies no nonlinear iterations, thus it is
computationally efficient for solving stiff problems. The trapezoidal
method has the same properties except for explicit formulation. It is
also adopted in this study for comparison. Numerical tests reveal that
the CPU demand for the new method is as small as 1.9%, 1.3%, 1.0% and
0.51% of that consumed by the trapezoidal method for a set of 250, 500,
1000 and 2000 first order ODEs. Consequently, it is computationally much
more cheap than the trapezoidal method in the solution of stiff
problems.
Numerical Simulation of Fuzzy Wave-Like Equations with Spatial Variable Coefficients by Lattice Boltzmann Method
Authors: zhang zongning , Li Chunguang , Dong Jianqiang , Yang Wei
Published: January 2024

In this paper, we develop a lattice Boltzmann model for a class of 1+1
dimensional nonlinear fuzzy wave-like equations with spatial variable
coefficients. By choosing properly the conservation condition between
the macroscopic quantity $u_{t}$ and the distribution functions and
applying the Chapman-Enskog expansion, the governing equation is
recovered correctly from the lattice Boltzmann equation. Moreover, the
local equilibrium distribution function is obtained. The results of
numerical examples have been compared with the analytical solutions to
confirm good accuracy and the equilibrium of our scheme.
Leukapheresis in Pediatric Acute Leukemia with Hyperleukocytosis: A Single-Center Experience
Authors: Jones Sandra , Rahrig April , Saraf Amanda
Published: January 2024

Background: Hyperleukocytosis in pediatric acute leukemia is associated
with increased morbidity and mortality and using leukapheresis (LPH) as
management is controversial. Procedure: At our tertiary referral center,
pediatric patients with newly diagnosed acute leukemia and a leukocyte
count of 100k/µL or greater were evaluated and compared based on the use
of LPH or not in management. Results: At our institution, LPH was used
in 8 of 62 (13%) patients with hyperleukocytosis with minimal
complications. Mean leukocyte count in patients who received LPH versus
those who did not was 498k/µL and 237k/µL, respectively. Patients who
received LPH were more likely to have symptoms of neurologic or
pulmonary leukostasis (63% vs 17%, 75% vs 17%, respectively).
Conclusions: The addition of LPH did not alter time to chemotherapy or
survival outcomes. Leukapheresis was safe and well tolerated at our
institution.
Crocin in eye diseases, a comprehensive review
Authors: Heydari Mojtaba , Zareh Mosa , Badie Mohammad Reza , Watson Ronald Ross , Talebnejad‬ Mohammad Reza , Afarid Mehrdad
Published: January 2024

Background Background: Crocin is a natural ingredient of saffron (Crocus
sativus L.) flower. Crocin has been examined for its potential to treat
various eye diseases such as glaucoma, macular dystrophies, diabetic
retinopathy, and age-related macular degeneration. Methods: This review
briefly discusses the role of crocin in different eye diseases. The
underlying pathophysiological pathways involved in the effect of crocin
on ophthalmologic diseases are also reviewed. Results: Preclinical
evidence shows the cytoprotective, antioxidative, anti-inflammatory, and
blood flow enhancing effects of crocin in retinal tissue. Crocin also
affects the retinal pathologies through activation of PI3K/Akt and
inhibition of NF-κB signaling pathways. Clinical evidence suggests that
crocin improves outcomes in patients with retinal degenerations, retinal
dystrophies, and glaucoma. Conclusion: Crocin can be used as a potential
vision supplement in healthy population and patients with eye diseases.
Vasculature regulator CsIVP modulates transport and high-temperature resistance in cucumber
Authors: Yan Shuangshuang , Yu Bingwei , Ming Fangyan , Liang Yonggui , Zhong Yanting , Wang Zhongyi , Zhang Xiaolan , Li Xuexian , Qiu Zhengkun , Cao Bihao
Published: January 2024

Crop plants experience various abiotic stresses that reduce yield and
quality. Although several adaptative physiological and defense responses
to single stress have been identified, the behavior and mechanisms of
plant response to multiple stresses remain underexamined. Herein, we
determined that the leaf and vascular changes in CsIVP-RNAi cucumber
plants can enhance resistance to nitrogen deficiency and
high-temperature stress. CsIVP negatively regulated high nitrate
affinity transporters (NRT2.1, NRT2.5) and reallocation transporters
(NRT1.7, NRT1.9, NRT1.12) under low nitrogen stress. Furthermore,
CsIVP-RNAi plants have high survival rate with low heat injury level
under high temperature condition. CsIVP mediated key high-temperature
regulators, including HSFs, HSPs, DREB2C, MBF1b, and WRKY33, in response
to high temperature. Altogether, these results show that CsIVP
integrates innate programming of plant development, nutrient transport,
and high-temperature resistance, providing a potentially valuable target
for breeding nutrient-efficient and heat-resistant crops. Identification
or creation of elite alleles conferring optimal fruit production,
nutrient use efficiency, and high-temperature resistance will bring
tremendous scientific and economic benefits.
Gender differences of patients treated with wearable cardioverter-defibrillator
Authors: Abumayyaleh Mohammad , El-Battrawy Ibrahim , Rosenkaimer Stephanie , Dreher Tobias C. , Kuschyk Juergen , Röger Susanne , Borggrefe Martin , Akin Ibrahim
Published: January 2024

Aims The treatment with the wearable cardioverter defibrillator (WCD)
may protect against sudden cardiac death (SCD) as a bridging therapy
until a cardioverter defibrillator may be implanted. Data regarding the
impact of WCD on the outcome of patients according gender differences
are limited. We analysed a consecutive patient cohort wearing WCD to
explore gender differences. Methods and results We analysed 153
consecutive patients of whom were 118 males and 35 females (age, 60±13
vs. 60±16 years old; p=0.88). More males receiving WCD as compared to
females suffered from ischemic cardiomyopathy (ICM) (41% vs. 23%;
p=0.05), while females were diagnosed with non-ischemic cardiomyopathy
(NICM) (60% vs. 42%); p=0.05). The wear time of WCD was equivalent in
both groups (21±4 in males vs. 22±3 hours/days in females; p=0.18; and
65±42 in males vs. 65±43 days in females; p=0.96). In both groups, the
left ventricular ejection fraction (LVEF) improved in males from 29±10%
to 41±12% and in females from 28±12% to 45±13%; p=0.12. At 6-12
month-follow-up, the LVEF increased more in females as compared to males
(40% vs. 17%; p=0.003). The rate of rehospitalization due to
cardiovascular cause and all-cause-mortality were comparable in both
groups at 6-12 month-follow-up (55% in male vs. 54% in female group;
p=0.93) (9% in male vs. 11% in female group; p=0.71). Conclusion
Compliance for wearing of WCD was excellent regardless of gender. During
follow-up, LVEF improved more in females as compared to males. All-cause
mortality and the rate of rehospitalization were comparable in both
groups.
Clofarabine monotherapy in two patients with refractory Langerhans cell histiocytosis
Authors: Irie Masahiro , Nakano Tomohiro , Katayama Saori , Suzuki Tasuku , Moriya Kunihiko , Watanabe Yuko , Suzuki Nobu , Saitoh-Nanjyo Yuka , Onuma Masaei , Rikiishi Takeshi , Niizuma Hidetaka , Sasahara Yoji , Kure Shigeo
Published: January 2024

Clofarabine (CLO) monotherapy reportedly induces a better clinical
response in some patients with refractory Langerhans cell histiocytosis
(LCH). We successfully treated two patients with refractory multisystem
LCH with CLO monotherapy after recurrence. We administered 23 courses of
CLO monotherapy in patient 1 and 4 courses in patient 2. Both patients
achieved a durable complete response with acceptable adverse effects of
transient myelosuppression. CLO monotherapy is a better therapeutic
option for high efficacy and feasibility than other combination
chemotherapies or allogeneic hematopoietic stem cell transplantation for
refractory LCH.
Evaluating the SARS-CoV-2 Specific Antibodies in Saliva
Authors: YU Siyang , Zhang Peiyan , Liao Mingfeng , Zhang Juanjuan , Luo Suisui , Zhai Jinglei , Zhang Yaxi , Lin Jingyan , Yuan Jing , Zhang Zheng , Wang Fuxiang , Wei Lanlan
Published: January 2024

Molecular assays on nasopharyngeal swabs act as the confirmatory test in
CoronaVIrus Disease (COVID-19) diagnosis. Despite massive efforts had
been made, the high technicalities of nasopharyngeal sampling and
molecular assays limit the testing capabilities. Currently, the use of
saliva for diagnosis has been recently suggested for COVID-19 diagnostic
testing. In a recent research, salivary IgA was associated with the
presence of pneumonia, which might illuminate that salivary IgA was
independent from serum immunoglobulins. In this study, a total of 44
patients diagnosed with COVID-19 in the Third People’s Hospital of
Shenzhen were enrolled. Saliva specimens and serum specimens were
obtained at different time points and the immunoglobulins against the
SARS-CoV-2 was measured. The results showed that saliva IgA presented
higher COI value than IgG and IgM. In matched saliva and serum samples,
all saliva presented lower IgG level than serum, and only one saliva
sample presented higher IgM level. The conversion rates of saliva IgA
and the detection of viral nucleic acid were analyzed in the first and
second week after hospitalization. The positive rates were obviously
increased when combining the saliva IgA and viral nucleic acid
detection. Saliva IgA could serve as useful index for early diagnosis of
COVID-19.
Biotechnology: use of available carbon sources on the planet to generate alternatives energy
Authors: Junior Jefferson Alves da Costa , Vicente Elisabete José , Marasca Elza Teresinha Grael , Torres Fernando Araripe Gonçalves , Moraes Lidia Maria Pepe , Bones Ubiratan Alegransi
Published: January 2024

Biotechnology has been an essential tool in the search for solutions and
in the optimization of bioprocesses associated with issues of human,
plant, animal, energy and also the balance of ecosystems on planet
Earth. The objective of this research was to present an unconventional
substrate (cellulose), in abundance on the planet, to be used as a
substitute source of carbon and energy for biotechnology processes, with
the possibility of increasing industrial production of biomass and
energy. As basis for the research, an extensive literature review and
quantitative and qualitative analyzes were carried out. We chose to
qualify the yeast Saccharomyces cerevisiae for partial cellulose
degradation, through the use of genetic transformation methods to insert
a plasmid carrying the cellobiohydrolase cDNA. It was found that the
recombinant and biologically active cellobiohydrolase protein was
expressed and excreted in haploid and diploid laboratory yeast strains.
The analyzes allowed the visualization of cellulolysis halos around
colonies of recombinant strains grown in solid YPD medium with 1%
microgranular cellulose. The recombinant clones derived from the haploid
lineage yielded in average of 1.70 mg ART/mL, while recombinant clones
derived from the diploid lineage produced in average of 2.05 mg ART/mL.
Lessons from a patient with tetralogy of Fallot, dextrocardia and cardiac arrest
Authors: Lin Manxin , Zhu Kailun , Chang Dong , Li Qiang
Published: January 2024

We report a rare case with a history of tetralogy of Fallot with
dextrocardia, who presented with palpitation and cardiac arrest upon
admission. This unusual complex condition and the atypical symptoms
obscured the primary cause of his cardiac arrest and posed challenges on
his diagnosis and treatment along with concomitant cardiac arrythmias.
Attitudes and experiences with termination of pregnancy among Irish obstetrics & gynaecology trainees in the context of recent legal change: a survey study
Authors: Stifani Bianca , McDonnell Brendan , Corbett Gillian , Avila Karina , Chavkin Wendy , Russell Noirin , Benfield Nerys
Published: January 2024

Objective: The objective of this study was to examine Irish obstetrics
and gynaecology trainees’ experiences with and opinions of termination
of pregnancy (ToP) after legal change. Design: this is a cross-sectional
web-based survey study. Setting: Republic of Ireland. Population: We
invited obstetrics & gynaecology non-consultant hospital doctors
(NCHDs) to participate in a web-based survey through a professional
e-mail listserv. Methods: We conducted descriptive statistical analyses
of responses using Stata SE Version 16. Main outcome measures: Irish
NCHDs’ reported future willingness to provide ToP. Results: A total of
102/202 (50.5%) trainees responded to the survey. Of these, 61.8%
believe that ToP should be allowed on request up to 12 weeks and in
limited circumstances thereafter (in line with current Irish law), and
19.6% believe ToP should be allowed on request even after 12 weeks.
Knowledge about the abortion law was high (70.6% achieved a perfect
knowledge score). Since the new law came into effect, 61.8% of trainees
reported having participated in abortion care, though only 25.5% have
performed surgical procedures. More than 75% of respondents would like
to receive more training in all clinical skills related to ToP (early
pregnancy ultrasound, first and second trimester medical and surgical
abortion). In the future, 67.6% of respondents would be willing to
provide TOP in all circumstances allowed by law. Conclusions: Irish
obstetrics & gynaecology trainees are generally supportive of the
legislation. Few trainees have performed surgical abortions, and most
would like to receive additional training in clinical skills related to
abortion care.
The relationship of Fetuin-A, Omentin-1 and Chemerin with clinical classification in Heart Failure
Authors: ömür Sefa , CERİK İDRİS BUĞRA , tekin Gülaçan
Published: January 2024

BACKGROUND: Heart failure (HF) is a clinical syndrome in which the heart
cannot pump enough blood for the needs of the human body in terms of
life functions. Some biochemical diagnostic tests as well as
echocardiography play a role in the early diagnosis of this syndrome.
The complex pathophysiology of HF suggests that many other markers may
be useful in diagnosis and follow-up. AIM: After many recent studies, it
has been suggested that adipokines fetuin-A, omentin-1 and chemerin may
be suitable biomarkers for the diagnosis of HF. Our main aim in this
study is to determine the relationship between fetuin-A, omentin-1 and
chemerin levels with HF clinical classification. METHOD: The patients
admitted to the cardiology service with symptomatic HF with heart
failure with preserved ejection fraction (HF-pEF, n=62), heart failure
with reduced EF (HF-rEF, n=61) and heart failure with mid-range EF
(HF-mrEF, n=63) were included in the study. A total of 246 participants
were evaluated by taking the control group (n=60) for comparison. The
main characteristics of all groups were recorded and serum levels of
fetuin-A, omentin-1 and chemerin were evaluated. RESULTS: When compared
with the control group, there was a significant difference for fetuin-A
with the HF-rEF group [452.3 (441.4-528.9); 555.3 (453.7-615.6)
p<0.001, respectively]. When evaluating for omentin-1, there
was a significant difference between the control group and HF-rEF
[19.3 (16.9-22.7); 22.9 (16.8-29.7) p<0.001,
respectively]. However, there was no significant difference for
chemerin between the HF groups and the control group. Significant
cut-off value for fetuin-A was found to be 485 in ROC analysis (AUC:
0.74 sens: 0.72 (95% CI: 0.57-0.82), spec: 0.69 (95% CI: 0.59-0.83),
p<0.001). CONCLUSION: Serum fetuin-A levels were found to be
increased in HF, especially in the HF-rEF group and it can be used in
the diagnosis of this patient group.
Synthesis and characterization of electroactive PEDOT platform with biologically active N-octylphenotiazine derivative
Authors: Krawczyk Sara , Golba Sylwia , Jurek-Suliga Justyna , Słodek Aneta
Published: January 2024

Poly(3,4-ethylenedioxythiophene) was synthesized in the presence of a
phenothiazine derivative (PTZN_C8). The purpose of the research is to
determine the influence of the presence of PTZN_C8 on state of order of
forming PEDOT chains and analysis of PTZN_C8 release. Synthesis of
PEDOT in the presence of a PTZN_C8 by cyclic voltammetry allowed to
characterize the resulting polymer films by determining the accumulated
charge capacity. Different synthetic protocols were used to obtain
layers of PEDOT as a matrix and phenothiazines derivative as a substance
which changed structure of material. Layers were investigated by FTIR to
identify the presence of compound incorporated during synthesis. The
degree of polymerization was calculated to characterize the length of
chains. UV-Vis spectra allowed to calculate the releasing curves of
PTZN_C8 from PEDOT matrix. Results showed that PEDOT was modified by
changing the length of the chains – as the content of the PTZN_C8 was
higher the chains were longer.
Study on Controllability Results for Semilinear Integrodifferential Evolution System with Non-local Delayed Impulses
Authors: BHEEMAN RADHAKRISHNAN , Thangavel Sathya
Published: January 2024

The foremost aim of this paper is to reveal the extent of the
controllability of the semilinear evolution integrodifferential impulse
system with delayed impulses and non local conditions. This paper begins
with the grit of the control formula for the same impulse system in
Banach space. Moreover, As a result, is extended to controllability. The
sufficient conditions are introduced by utilizing the Hausdorff measure
of noncompactness, Sadovskii fixed point theorem, and operator
semigroups in appropriate dropping compactness of the operator.
Sequentially, an example is provided to show our results.
Immunopathologic characteristics of Chinese pediatric chronic rhinosinusitis
Authors: Jiang Lijie , Zeng Yinhui , Huang Zhaoqi , tang yiquan , Zeng Qing-Xiang , Shi Jian-Bo , Liu Wenlong
Published: January 2024

Background: The histopathology of pediatric chronic rhinosinusitis with
nasal polyps (CRSwNP) and without nasal polyps (CRSsNP) is rarely
reported due to their low prevalence or the unavailability of tissue
samples. Hence, we aimed to characterize and compare the histologic
features and protein expression of Th1/Th2/Th17-related cytokines in
pediatric CRSsNP and CRSwNP. Methods: The histologic characteristics of
15 children with CRSsNP, 52 children with CRSwNP, and 12 control
participants were analyzed using hematoxylin and eosin staining. The
expression of Th1/Th2/Th17-related cytokines were examined using
immunohistochemistry and the enzyme-linked immunosorbent assay. Results:
Pediatric subjects with CRSwNP had more intact epithelium and less
submucosal mucous glands compared to those with CRSsNP. Tissue
eosinophils were more prevalent in the young CRSwNP group compared to
the old CRSwNP or the CRSsNP groups. The protein concentrations of Th2
cytokines were significantly higher in the CRSwNP group than the CRSsNP
group or the control group. Moreover, the protein concentrations of Th17
cytokines were significantly higher in the young CRSwNP group than the
old CRSwNP group or the CRSsNP and control groups. The protein
concentrations of Th1 and Th17 cytokines were also significantly higher
in the CRSsNP group than the control group. Compared with
non-eosinophilic CRSwNP, eosinophilic CRSwNP presented with elevated
protein concentrations of Th1 and Th17 cytokines. Conclusion: For the
first time, we showed that pediatric CRSwNP presents as eosinophilic
with Th2/Th17 inflammation, whereas CRSsNP presents as Th1/Th17
inflammation. Our study may provide a theoretical basis for the precise
treatment of pediatric CRS in the future.
Peptidylglycine alpha-amidating monooxygenase as a therapeutic target or biomarker
Authors: Merkler David , Hawley Aidan , Eipper Betty , Mains Richard
Published: January 2024

Peptides play a key role in controlling many physiological and
neurobiological pathways. Many bioactive peptides require a C-terminal
α-amide for full activity. The bifunctional enzyme catalyzing
α-amidation, peptidylglycine α-amidating monooxygenase (PAM), is the
sole enzyme responsible for amidated peptide biosynthesis, from
Chlamydomonas reinhardtii to Homo sapiens. Many neuronal and endocrine
functions are dependent upon amidated peptides; additional amidated
peptides are growth promoters in tumors. The amidation reaction occurs
in two steps, glycine α-hydroxylation followed by dealkylation to
generate the α-amide product. Currently, most potentially useful
inhibitors target the first reaction, which is rate-limiting. PAM is a
membrane-bound enzyme that visits the cell surface during peptide
secretion. PAM is then used again in the biosynthetic pathway, meaning
that cell-impermeable inhibitors or inactivators could have therapeutic
value for the treatment of cancer or psychiatric abnormalities. To date,
inhibitor design has not fully exploited the structures and mechanistic
details of PAM.
A comparison between GeneXpert testing and the Berlin-Charité diagnostic protocol for the detection of SARS-CoV-2 in a cohort of Mexican patients.
Authors: Vargas Eduardo Becerril , Cueva Andrea Delgado , Konigsberg Gabriel Cojuc , Razon Gaston Becherano , Garcia Yessica Velasco , orozco José Martinez , Tinajero Angel Sanchez , Santillán Danna Patricia Ruiz , Vilar-Compte Diana , Martinez Daniel de la Rosa , Juarez Etzael Antonio , Sanchez Victor Rodriguez , Trujillo Daniel Valencia , Colin Maria Garcia , Sanchez Mario Mujica , Davalos Christian Mireles , Molina Yamil Monitel
Published: January 2024

Since the beginning of the SARS-CoV-2 pandemic healthcare professionals
have found it necessary to generate diagnostic methods for the disease
that are easy to use, reliable, and accessible. The Berlin-Charité
protocol has been one of the most recommended methods for detecting
SARS-CoV-2 from the onset of the pandemic. However, new diagnostic
techniques such as GeneXpert have been developed and proven to be
efficient, fast, and easy to use to detect infected patients. The
purpose of this study, conducted at the National Institute for
Respiratory Diseases in Mexico, was to compare the diagnostic
performance of the Berlin-Charité protocol and GeneXpert for the
detection of SARS-CoV-2, evaluating a cohort of 135 Mexican patients.
For statistical analysis, sensitivity, specificity, positive predictive
value, negative predictive value, and likelihood ratios for each assay
were calculated. The diagnostic parameters for GeneXpert were found to
be 100% in both sensitivity and specificity. The Berlin-Charité
protocol performance had a sensitivity of 72% and specificity of 100%.
With this study, it can be concluded that the diagnosis of SARS-Cov_2
infection through GeneXpert was 29% more specific than the Berlin
protocol.
A More Accurate Half-Discrete Hilbert-Type Inequality Involving One Higher-Order Derivative Function
Authors: He Bing , Yang Bicheng
Published: January 2024

By means of the weight functions, Hermite-Hadamard’s inequality and the
technique of real analysis, a new more accurate half-discrete
Hilbert-type inequality involving one higher-order derivative function
is given. The equivalent conditions of the best possible constant factor
related to a few parameters, the equivalent forms, several particular
inequalities and the operator expressions are considered.
Superior mediastinal syndrome in a child with B-cell acute lymphoblastic leukemia: A case report
Authors: Ain Rahat Ul , Faizan Mahwish , Fatima Saba , Mahmood Khalid
Published: January 2024

Superior mediastinal syndrome secondary to an anterior mediastinal mass
can be seen in acute lymphoblastic leukemia of T-cell lineage. We report
a 3 years old child with B-cell ALL, who presented with superior
mediastinal syndrome. The CT scan chest showed a huge anterior
mediastinal mass and the peripheral blood immunophenotying showed B-cell
acute lymphoblastic leukemia. High-risk remission induction chemotherapy
was given and he achieved remission by the end of induction therapy,
both in terms of medullary and extramedullary disease. This is the first
reported case of a pediatric B-cell ALL presenting with the superior
mediastinal syndrome.
Congenital aorto-right ventricular fistula in a 31-year-old female
Authors: Okino Arnaldo , Petinelli Renan , Pires Marcos , Fonseca João , Khalil Kalil , Luvizotto Jaqueline
Published: January 2024

Aorto-right ventricular fistula is a rare condition that communicates
the ascending aorta to the right ventricle. This case describes a
31-year-old female attended at the outpatient clinic with a complain of
dyspnea and edema in the lower limbs lasting about 2 months. Physical
evaluation showed a holosystolic heart murmur on cardiac auscultation.
Echocardiography and cardiac catheterization revealed a communication
between the right coronary sinus to the right ventricular outflow tract.
The patient underwent cardiac surgical treatment to correct the defect,
in which fistula tissue was resected and the orifice was closed with
bovine pericardium. The patient was discharged at the fifht day after
procedure, and a postsurgical echocardiography did not show
communication between the right sinus of valsalva to the right ventricle
anymore.
Torsade de Pointes: A Nested Case Control Study in an Integrated Health Care Delivery System
Authors: Mantri Neha , Lu Meng , Zaroff Jonathan , Risch Neil , Hoffmann Thomas , Oni-Orisan Akinyemi , Lee Catherine , Iribarren Carlos
Published: January 2024

Background. TdP is a form of polymorphic ventricular tachycardia which
develops in the setting of a prolonged QT interval. There is limited
data describing risk factors, treatment and outcomes of this potentially
fatal arrhythmia. Objective: Our goals were: 1) to validate cases
presenting with Torsade de Pointes (TdP); 2) to identify modifiable risk
factors; and 3) to describe the management strategies used for TdP and
its prognosis in a real-world health care setting. Methods. Case-control
study (with 2:1 matching on age, sex and race/ethnicity) nested within
the Genetic Epidemiology Research on Aging (GERA) cohort. Follow-up of
the cohort for case ascertainment was between 01/01/2005 and 12/31/2018.
Results. A total of 56 cases of TdP were confirmed (incidence rate= 3.6
per 100,000 persons/years). The average (SD) age of the TdP cases was 74
(13) years, 55 percent were female and 16 percent non-white. The
independent predictors of TdP were potassium concentration <
3.6 mEq/L (OR=10.6), prior history of atrial fibrillation/flutter
(OR=6.2), QTc > 480 ms (OR=4.4) and prior history of
coronary artery disease (OR=2.6). Exposure to furosemide and amiodarone
were significantly greater in cases than in controls. The most common
treatment for TdP was IV magnesium (78.6%) and IV potassium repletion
(73.2%). The in-hospital and 1-year mortality rates for TdP cases were
10.7% and 25.0% percent, respectively. Conclusions. These findings may
inform quantitative multivariate risk indices for the prediction of TdP
and could guide practitioners on which patients may qualify for
continuous ECG monitoring and/or electrolyte replacement therapy.
Bloom timing explains succession of protistan functional effect trait community structure
Authors: Péquin Bérangère , LaBrie Richard , St-Gelais Nicolas , Maranger Roxane
Published: January 2024

Given the important role of protists in trophodynamics and major
biogeochemical cycles, identifying which factors influence the
distribution of their biomass and species composition is a central tenet
in oceanography. However, understanding the drivers of that distribution
from a functional trait perspective would allow us to better link
protistan biogeography to ecosystem function. Here we evaluated the
distribution of protistan functional traits across the Labrador Sea
during spring over three consecutive years. More variability in the
biogeography of protistan functional traits was explained across water
masses, and among years than taxonomic composition. Furthermore,
patterns in trait variability were more apparent when site-specific
timing of peak chlorophyll-a was considered. By recreating bloom
phenology, we found that approximately 20 days prior to peak, mixotrophs
were replaced by autotrophs of different size classes, supporting the
critical role of bloom timing in structuring protistan community trait
succession with consequences on modelling of ecosystem function.
Combined use of S-ICD and absorbable antibacterial envelopes: a proof-of-concept study
Authors: Gasperetti Alessio , Schiavone Marco , Ziacchi Matteo , Zanchi Simone , Leonida Lombardi , Viecca Maurizio , Greca Carmelo La , Lavalle Carlo , Biffi Mauro , Forleo Giovanni
Published: January 2024

Absorbable antibacterial envelopes (AAEs) are currently recommended in
patients undergoing a transvenous ICD implantation in cases at high-risk
of infection, who are indeed now preferably implanted with a
subcutaneous ICD (S-ICD), whenever possible. Nevertheless, experiences
using a combined approach with S-ICD and AAE have not been reported,
therefore, aim of our study was to evaluate this strategy in patients at
very high-risk of infection. Sixteen patients were implanted with the
S-ICD+AAE using our combined approach, restricted to patients who would
fit our decisional flow algorithm. Despite a very high-risk, only a
single pocket infection was observed over the entire follow-up that was
managed conservatively and solved with antibiotic therapy. The
preliminary data of this proof-of-concept study show how a combined
deployment of AAE and S-ICD in selected patients at very high-risk of
infection is safe, feasible and may offer a true clinical benefit in
specific clinical settings.
Treatment of Type 2 diabetes mellitus case leading to successful IVF pregnancy and birth outcome.
Authors: Hashimoto Tomomi , Nakabayashi Akira , Yanagisawa Keiko , Toma Chihiro , Horibe Yu , Tabata Tsutomu
Published: January 2024

In type 2 diabetes patients, attempting oocyte retrieval for egg
cryopreservation without having established glycemic control does not
yield good results. Strict dietary treatment and appropriate insulin
administration is the best way to pregnancy.
Effects of different nitrogen sources on methane production and removal of free ammonium and hydrogen sulfide in anaerobic digestion of cheese whey
Authors: Cueva Sergio Cisneros de la , Balagurusamy Nagamani , Vega Samuel Perez , Reyes Ildebrando Perez , Castillo José Vazquez , Serna Francisco Zavala Díaz de la , Salmerón Ivan
Published: January 2024

In the present study, the effect of different nitrogen sources on the
anaerobic digestion of cheese whey was tested in batch scale reactors
concerning methane production, free ammonia, and hydrogen sulfide. The
results showed that supplementation with urea at a concentration of 1000
mg L-1 led to less variation in the FOS/TAC ratio, permitting greater
stability to the anaerobic digestion process and as well as having the
highest methane production values of 513.95 ± 2.12 mL CH4 g VS-1. On the
other hand, supplementation with ammonium nitrate at a concentration of
1000 mg L-1 gave a lower value of methane 415.93 ± 5.44 mL CH4 g VS-1
and exhibited the lowest value of hydrogen sulfide 267.69 ± 0.37 ppm, as
well as recorded the lowest free ammonium concentration of 49.18 ± 9.66
mg L-1. The findings from this research contributed to elucidate the
role of urea, ammonium sulfate, and ammonium nitrate in the anaerobic
digestion process, which could help to solve some problems related to
the reduction in biogas and methane yield, correlated to the presence of
hydrogen sulfide and free ammonium in cheese whey fed biodigesters.
Assessment of breast cancer screening services uptake amid women of childbearing age in three senate zones of Abia State, Nigeria
Authors: Onwuchekwa Elendu , Ekeleme Uzochkwu , Nwokoro Roseline , Oha Ndubuisi , Onuigbo Martin , Maduagwu Queen Chinyeree , OWOLABI MUTIU , Ikwuagwu Vivian
Published: January 2024

Introduction: Globally, breast cancer is a threat to human life in which
Nigeria is not excluded. One of the best techniques in tackling breast
cancer disease is to get women screened for the disease earlier enough.
Aim: Assessment of breast cancer screening services uptake amid women of
child-bearing age in three senate zones of Abia State, Nigeria. Method:
A total of 1176 women were sampled using a multi-stage technique, a
validated questionnaire was administered to obtain information from the
respondents that consented to the study. Breast cancer uptake was
considered as having been screened with at least one of the three known
methods such as breast self-examination (BSE), clinical breast
examination (CBE), and mammography. Data analysis was performed using
descriptive technique and Chi-square test for association in the data.
Results: The overall level of breast cancer screening services uptake
was 25.1% and uptake was 23.7% for BSE, 21.3% for CBE, and 3.7% for
mammography. Up to 85.1% of those have been screened only once a year.
The women (52.2%) are aware of any breast cancer screening services.
Significant socio-demographic associating factors of uptake for breast
cancer screening services include age (χ2=50.44, p=0.0001), marital
status (χ2=47.81, p=0.001), education (χ2=393, p=0.0001) occupation
(χ2=319.4, p=0.0001), income (χ2= 268.7, p=0.0001) and age at first
pregnancy (χ2=74.8, p=0.0001). Uptake was highest among the 45 -49 years
(32.9%), married (31.4%), tertiary education level participants
(68.7%), Public / civil servants (66.5%). Family history was also
found as another significant associating factor and up to 80.5% among
the family history group undertook breast cancer screening services
uptake compared to 9.2% among the non-family history group. Conclusion:
Uptake in breast cancer screening is quite low among the study group
possibly due to low level of knowledge, poor attitude, family history,
and other associating factors.
A Case Report of Ventricular Fibrillation Supported by Left Ventricular Assist Device For Hours.
Authors: Doğanözü Ersin , Ersoy Ozgur , Sezgin Atilla , Özin Mehmet
Published: January 2024

In recent years, patients with left ventricular assist device (LVAD) has
been increasing result of ageing population increased heart failure.
LVAD implantation is a challenging operation, has lots of perioperative
and post operative complications. In this case, we aimed to discuss the
therapeutic approach to a patient with LVAD with ventricular
fibrillation and the pathophysiology of his clinical condition.
Short term effects of Technetium-99 conjugated with methylene diphosphonate (99Tc-MDP) & oral glucocorticoids on lipid profiles in Chinese patients with active rheumatoid arthritis
Authors: Huang Heqing , Wang Ying , Lin Qingyan , He Yan , Chen Rongjuan , Zhang Mengqin , Zeng Xiaoli , Li Yan , Xuan Jingxiu
Published: January 2024

Objective Consideration of 99Tc-MDP and glucocorticoids are widely
treated the patients with active RA in China, we wondered whether
99Tc-MDP or and oral glucocorticoids had an effect on lipid profiles in
short term. Patients & Methods Patients with active RA were divided
into two groups, who were treated with 99Tc-MDP or and GCs for 10 days.
ESR, CRP and DAS28, lipid profiles were detected at baseline and the
10th day of treatment. Comparison of inflammatory markers and lipid
profiles between treatment before and after was run by t test. The
correlation coefficient between inflammatory markers and lipid levels
was computed by nonparametric Spearman correlation analysis and line
regression analysis. Results ESR, CRP and DAS28CRP or ESR were decreased
significantly after treatment in the two groups. The levels of TG and
ApoA1 were increased significantly in the group of 99Tc, while the ratio
of ApoB/ApoA1 was decreased. In the group of 99Tc & GC, CHO, TG, and
HDL-C, ApoA1 were increased after treatment, atherogenic index and the
ratio of ApoB/ApoA1 both got down. Correlation analysis showed that CHO,
LDL-C and ApoB inversely related to DAS28CRP or ESR in the group of
99Tc. HDL-C, TG and ApoA1, and ratio of ApoB/ApoA1 or atherogenic index
were correlated with CRP, ESR or DAS28 ESR or CRP in the group of 99Tc
& GC. Conclusions RA patients treated with 99Tc-MDP or and oral
glucocorticoids occurred inflammatory attenuation, disease activity
reduction as well as lipid profile changes.