bluuebunny/crossref_metadata_2025 huggingface dataset:
DO LIVRO ARTESANAL CASA DE PAPEL, DE GLAUCIA DE SOUZA, AO LIVRO INDUSTRIAL AVOADA, DE MARILIA PIRILLO: CASAS PARA MORAR E BRINCAR
Authors: Debus Eliane Santana Dias
Published: February 2019

O presente artigo traz à cena os livros brasileiros para infância Casa de papel, de Gláucia de Souza (2017), e Avoada, de Marilia Pirillo (2014), buscando analisar os aspectos brincantes de suas feituras. O primeiro é marcado pela construção manual, edição comemorativa aos 20 anos de carreira literária, e o segundo, embora marcado pela construção industrial, apresenta estrutura dobrável, em forma de sanfona. O projeto gráfico-editorial de ambos os livros, alvos da análise, são originais e criativos, distanciando-se, de certo modo, da estrutura mercadológica dos livros para infância. Pela elaboração original, como objeto manuseável, a potência comunicativa do livro se amplia, expandindo, por certo, os horizontes do leitor.
Teología y neurociencias. Una articulación para otra comprensión de la especificidad interna de la teología
Authors: Valenzuela Osorio Vicente
Published: February 2019

El encuentro entre teología y neurociencias exige una articulación mediada por conceptos filosóficos y hermenéuticos. Pero no basta con establecer puentes reflexivos entre lenguajes y campos epistémicos. De cara a la teología, es necesario generar una comprensión alternativa que incida en la formulación de su especificidad interna. Aparecen claves interpretativas fundamentales como carne viviente, sensibilidad, relacionalidad, ser proyecto, organismo viviente. Ellas permiten la estructuración del discurso que se pretende. Lo específico de la teología queda formulado a partir del establecimiento de una racionalidad epistemológica y de una sola fuente primera y constitutiva de la teología (distinta a la escritura, tradición y magisterio, que no se reconocen como fuentes sino como medios de transmisión).
Człowiek – Media – Edukacja, red. nauk. Janusz Morbitzer, Danuta Morańska, Emilia Musiał, Dąbrowa Górnicza: Wydawnictwo Naukowe Wyższa Szkoła Biznesu 2017, s. 236. ISBN 978-83-65621-29-0
Authors: Wojciechowski Jacek
Published: February 2019

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Rejestr ksiąg Stanisława Smoły z Wolborza w inkunabule ze zbiorów Biblioteki Uniwersyteckiej w Poznaniu
Authors: Łukaszewski Jakub
Published: February 2019

Biblioteka Uniwersytecka w Poznaniu w 2017 roku nabyła wydanie dzieła Wilhelma Duranta Rationale divinorum officiorum (Nürnberg: Antonius Koberger, 19 IV 1480, 2o). Na wyklejce przedniej okładki tego inkunabułu znajduje się spis ksiąg z 1553 roku. W artykule przedstawiono losy tego woluminu (dotąd uchodził za stratę wojenną) oraz dokonano analizy spisu ksiąg. Wynika z niej, że właścicielem księgozbioru ujętego w rejestrze był Stanisław Smoła z Wolborza (pierwsza połowa XVI wieku), bakałarz sztuk i rektor szkoły przy kościele św. Szczepana w Krakowie. Do tekstu artykułu dołączono edycję treści spisu ksiąg z objaśnieniami.
Jan Aleksiński (1949–2018)
Authors: Jazdon Andrzej
Published: February 2019

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Druki jezuickie w kręgach prawosławnych: dwa przykłady z XVII-wiecznej Rzeczypospolitej
Authors: Korzo Margarita A.
Published: February 2019

Tłumaczenia dzieł jezuitów Fulvia Androzziego (1523–1575) i Marcina Śmigleckiego (1563/64–1618) na język cerkiewnosłowiański i tzw. prostą mowę rozpatrywane są jako ciekawy przykład funkcjonowania utworów katolickich w XVII-wiecznym środowisku prawosławnym w Rzeczypospolitej. Della frequenza della communione (1579) Androzziego powstał jako traktat o częstym przyjmowaniu komunii. Oba jego przekłady polskie: w wersji skróconej Stanisława Grochowskiego (Scieszka poboznego chrześcianina, 1600) i pełnej Szymona Wysockiego (Skarbnica duchowna, 1600) stały się źródłem lakonicznego kazania wzorcowego na pogrzeb w składzie prawosławnego Rytuału (Wilno 1621). Traktat teologiczno-prawny o pobieraniu procentów i o kontraktach Śmigleckiego (O lichwie i trzech przednieyszych kontrakciech, Wilno 1596) został częściowo włączony do pierwszego prawosławnego manuale spowiedniczego Mir s Bogom čeloveku (Kijów 1669). Zarówno kazanie wzorcowe, jak i manuale spowiednicze należały do nowych gatunków literatury religijnej, które zaczęły powstawać w piśmiennictwie prawosławnym dopiero w XVII wieku pod wpływem tradycji katolickiej.
Biblioteka akademicka i nauka w procesie transformacji cyfrowej: próba diagnozy
Authors: Hudzik Krystyna
Published: February 2019

Rozważania dotyczą bibliotek akademickich oraz nauki w znaczeniubadań naukowych. Obydwa obszary – biblioteka i nauka – od prawie 30 lat znajdują się w procesie przemian określanych ostatnio mianem transformacji cyfrowej. Nauka tworzy nowoczesne technologie cyfrowe, a te z kolei zmieniają ją samą przez dostarczanie nowych narzędzi i metod badawczych oraz sposobów komunikacji. Z kolei zadaniem bibliotek jest dopasowanie się do nauki i nadążanie za jej oczekiwaniami w zapewnieniu potrzebnej do badań literatury i informacji. Podstawowe pytaniebrzmi: czy biblioteka i nauka są dziś na tym samym torze transformacji cyfrowej?
Dwudziestolecie Zakładu i Katedry Historii Wychowania w Uniwersytecie Szczecińskim (1992–2012)
Authors: Jankowski Robert
Published: February 2019

The History of Education, one of the courses offered at teacher education studies at the University of Szczecin, has been taught since the 1960’s. It was then when Teacher Education College in Szczecin was set up as a branch of Adam Mickiewicz University, Poznań. In 1973 Teacher Education College was transformed into an independent unit – Pedagogy Academy. The establishment of the University of Szczecin in 1985 marked a new chapter in the process of the development of the history of education as a course offered at pedagogical studies. History of Education Department was set up in 1992 and professor Danuta Koźmian was chair of the department throughout its existence. Scientific and didactic work of professor Danuta Koźmian first at Teacher Education College, through Pedagogy Academy and the University of Szczecin has been crucial for the development of the history of education as a course taught at teacher education studies in Szczecin. In 2008 professor Danuta Koźmian retired and the Council of the Faculty of Humanities at the University of Szczecin established the Chair for the History of Education appointing professor Wiesław Andrukowicz,  Ph.D its head.
Reformy dyktuje system – o naradzie oświatowej KC PZPR z 24 października 1958 roku
Authors: Król Joanna
Published: February 2019

The system dictates the reforms – on the educational conference of the Central Committee of the Communist Party on 28 October 1958The subject of the article is the educational conference which was held on 28 October 1958. It is believed that this meeting, in particular W. Gomulka’s speech, designated the main directions of future educational policy. Gomulka’s speech contained the following conclusions: the extension of compulsory education, the development of vocational education, professionalization of education and ideologisation of teacher training. A very important part of Gomulka’s speech was the issue of teaching religion. Although Gomulka promised to comply with the agreement concluded with the Church on teaching religion, he on the other hand criticized the conduct of the clergy on emblems and religious practices. The participants of the conference were more radical than Gomulka and advocated the total elimination of religious education in school. Strangely enough, all of the main conclusions of the meeting were subsequently turned into legislation. The crowning achievement of the speakers of 1958 became the law on the development of the system of education in 1961, which introduced secular schools and socialist educational ideals.
A new method for constructing Pb-210 chronology of young peat profiles sampled with low frequency
Authors: Sikorski Jarosław
Published: February 2019

The paper presents the results of measurements the specific concentration of lead-210 for six peat profiles representing four peat bogs from two regions of Poland and the problem of creating age-depth models. For the construction of age-depth models, it is proposed to use mathematical functions, the best fit to the measured activity. The F-statistics were used as a measure of the match quality. The obtained models are visualized in two ways – showing the age calculated on the basis of direct measurements of activity and indicating points that are the results of the used approximation. Such visualization is important to clearly distinguish the places of the age-depth model that result from the measurements of activity from those places that are the result of the approximation used.

This paper proposes and tests the application of activity modelling for the cores shorter than the range of the lead method. The paper also outlines the limitations and potential dangers related to the interpretation of core dating results i) obtained by using the activity approximation resulting in the smoothing of the age-depth profile, and ii) for the cores of a length smaller than the depth of the presence of the unsupported lead.

Additionally, the proposed models were compared with the models obtained by using SIT, Mod-Age, OxCal, Clam, and Bacon programs.
In vitro and in vivo toxicity assessment of biologically synthesized silver nanoparticles from Elaeodendron croceum
Authors: Odeyemi S. W. , De La Mare J. , Edkins A. L. , Afolayan A. J.
Published: February 2019

Background

The cytotoxic properties of nanoparticles have attracted a great deal of attention in the field of nanoscience and nanotechnology due to their small size and ability to penetrate cellular membranes.

Methods

The silver nanoparticles were synthesized using Elaeodendron croceum stem bark and characterized. The oral acute toxicity studies were carried out by administration of 500, 1000, 2000 mg/kg body weight to Wister rats in respective groups. An in vitro cytotoxicity assay was evaluated in MDA-MB-231 breast cancer cells using the WST-1 Cell Proliferation assay. The percentage of cell viability after treatment with aqueous extracts of Elaeodendron croceum (ECE) and Elaeodendron croceum silver nanoparticles (ECAgNPs) was compared with that of paclitaxel.

Results

The in vivo studies revealed that the LD50 was higher than 2000 mg/kg and there was no significant difference (p>0.05) between the treatment groups compared with the control group for mean organ-to-body weight ratio except in the liver and in all hematological parameters except WBC and hematocrit. Similarly, there was no significant difference (p>0.05) for serum electrolytes (Na+, Mg2+ K+, Cl−, and Ca2+), total protein, urea, ɣ-glutamyl transferase (GGT), Aspartate aminotransferase (AST), Alkaline phosphatase (ALP), Alanine aminotransferase (ALT), albumin, total and conjugated bilirubin between the treatment and the control group. However, there were changes in creatinine, urea, and cholesterol. In the in vitro assays, ECE and ECAgNPs showed IC50 values of 70.87±2.99 and 138.8±3.98 µg/mL respectively against MDA-MB-231 cells compared to paclitaxel, which showed an IC50 value of 80 ng/mL.

Conclusion

The results showed that the LD50 of the ECE and ECAgNPs in Wister rats was determined to be greater than 2000 mg/kg body weight. The aqueous extract also showed more cytotoxic than the ECAgNPs suggesting that the toxic compounds in aqueous extract were involved in the capping of the AgNPs.
Numerical Analysis of Optical Properties Using Octagonal Shaped Photonic Crystal Fiber
Authors: Rashed Ahmed Nabih Zaki , Tabbour Mohammed Salah F. , Vijayakumari P.
Published: February 2019

In this paper, we propose a design of octagonal photonic crystal fiber with relevant parameters such as effective mode index, propagation constant, second-order dispersion and field distribution of fundamental mode (LP01). The measured parameters can be applied for generating supercontinuum, and also this model is used especially for generating vortex modes and OAM modes in space division multiplexing (SDM) applications. Highly negative dispersion is achieved at −800 ps/nm.km at wavelength of 1.1 μm, and second-order dispersion profile leads to study about the nonlinearity as well as broadband spectrum of the proposed model.
Mechanism of amyloid protein aggregation and the role of inhibitors
Authors: Linse Sara
Published: February 2019

Inhibition of amyloid β peptide (Aβ) aggregation is an important goal due to the connection of this process with Alzheimer’s disease. Traditionally, inhibitors were developed with an aim to retard the overall macroscopic aggregation. However, recent advances imply that approaches based on mechanistic insights may be more powerful. In such approaches, the microscopic steps underlying the aggregation process are identified, and it is established which of these step(s) lead to neurotoxicity. Inhibitors are then derived to specifically target steps involved in toxicity. The Aβ aggregation process is composed of at minimum three microscopic steps: primary nucleation of monomers only, secondary nucleation of monomers on fibril surface, and elongation of fibrils by monomer addition. The vast majority of toxic species are generated from the secondary nucleation process: this may be a key process to inhibit in order to limit toxicity. Inhibition of primary nucleation, which delays the emergence of toxic species without affecting their total concentration, may also be effective. Inhibition of elongation may instead increase the toxicity over time. Here we briefly review findings regarding secondary nucleation of Aβ, its dominance over primary nucleation, and attempts to derive inhibitors that specifically target secondary nucleation with an aim to limit toxicity.
Can we safely predict solvation Gibbs energies of pure and mixed solutes with a cubic equation of state?
Authors: Moine Edouard , Privat Romain , Jaubert Jean-Noël , Sirjean Baptiste , Novak Nefeli , Voutsas Epaminondas , Boukouvalas Christos
Published: February 2019

Solvation Gibbs energies are basically defined as a chemical potential change when transferring a fixed molecule from a perfect gas to a real liquid mixture. This quantity is of special interest for many practical applications as it quantifies the degree of affinity of a solute for its solvent. Few methods are currently available in the literature for the prediction of solvation Gibbs energies. In this article, a new approach is proposed: the use of a predictive cubic equation of state (EoS). The UMR-PRU (Universal Mixing Rule Peng-Robinson UNIFAC) EoS has been selected for its known capacity to semi-predict behaviors of complex systems including polar and associating compounds (by semi-prediction, it is meant that the EoS predicts binary interaction parameters but requires pure-component properties as input parameters). UMR-PRU predictions have been compared to experimental data extracted from the extensive CompSol database (containing around 22 000 pure component data and 70 000 binary data). Accurate predictions were obtained (a mean absolute deviation of 0.36 kcal/mol was obtained for all the binary data). Finally, when using a fully-predictive approach (i.e. pure-component EoS parameters are predicted from group-contribution methods), the prediction accuracy is roughly preserved.
Meta-analytic framework for modeling genetic coexpression dynamics
Authors: Kinzy Tyler G. , Starr Timothy K. , Tseng George C. , Ho Yen-Yi
Published: February 2019

Methods for exploring genetic interactions have been developed in an attempt to move beyond single gene analyses. Because biological molecules frequently participate in different processes under various cellular conditions, investigating the changes in gene coexpression patterns under various biological conditions could reveal important regulatory mechanisms. One of the methods for capturing gene coexpression dynamics, named liquid association (LA), quantifies the relationship where the coexpression between two genes is modulated by a third “coordinator” gene. This LA measure offers a natural framework for studying gene coexpression changes and has been applied increasingly to study regulatory networks among genes. With a wealth of publicly available gene expression data, there is a need to develop a meta-analytic framework for LA analysis. In this paper, we incorporated mixed effects when modeling correlation to account for between-studies heterogeneity. For statistical inference about LA, we developed a Markov chain Monte Carlo (MCMC) estimation procedure through a Bayesian hierarchical framework. We evaluated the proposed methods in a set of simulations and illustrated their use in two collections of experimental data sets. The first data set combined 10 pancreatic ductal adenocarcinoma gene expression studies to determine the role of possible coordinator gene USP9X in the Hippo pathway. The second experimental data set consisted of 907 gene expression microarray Escherichia coli experiments from multiple studies publicly available through the Many Microbe Microarray Database website (http://m3d.bu.edu/) and examined genes that coexpress with serA in the presence of coordinator gene Lrp.
Über das Sichtbare hinaus. Eine Soziologie künstlerischer Praxis
Authors: Schürkmann Christiane
Published: February 2019

Mit einer ethnografischen Perspektive untersucht der Aufsatz künstlerische Praxis im Feld der bildenden Kunst. Ins Zentrum rückt die Frage, wie Kunstwerke beziehungsweise künstlerische Arbeitenin situhervorgebracht werden. Dabei folgt die Ethnografin den PraktikerInnen respektive den KünstlerInnen und ihrem situierten Tun. In Form soziologisch-ethnografischer Analysen wird gezeigt, 1) wie eine bestimmte Praxis künstlerisch qualifizierten Sehens an Kunsthochschulen geübt wird, 2) wie künstlerische Praxis als Interaktion zwischen Körper und Material hervortritt, 3) wie KünstlerInnen ihre Arbeiten durch ästhetisches Antizipieren entwickeln und beurteilen und schließlich 4) wie KünstlerInnen sich gegenüber ausgestellten Werken kritisch positionieren. Formuliert wird der Ansatz einer Soziologie künstlerischer Praxis mit dem Ziel, Kunst in ihren epistemischen und sinnlichen Potenzialen für die Kunst- und Wissenssoziologie weitergehend zugänglich zu machen.
Increased Alcohol-Drinking Induced by Manipulations of mGlu5 Phosphorylation within the Bed Nucleus of the Stria Terminalis
Authors: Campbell Rianne R. , Domingo Racquel D. , Williams Amy R. , Wroten Melissa G. , McGregor Hadley A. , Waltermire Ryan S. , Greentree Daniel I. , Goulding Scott P. , Thompson Andrew B. , Lee Kaziya M. , Quadir Sema G. , Jimenez Chavez C. Leonardo , Coelho Michal A. , Gould Adam T. , von Jonquieres Georg , Klugmann Matthias , Worley Paul F. , Kippin Tod E. , Szumlinski Karen K.
Published: February 2019

The bed nucleus of the stria terminalis (BNST) is part of the limbic-hypothalamic system important for behavioral responses to stress, and glutamate transmission within this region has been implicated in the neurobiology of alcoholism. Herein, we used a combination of immunoblotting, neuropharmacological and transgenic procedures to investigate the role for metabotropic glutamate receptor 5 (mGlu5) signaling within the BNST in excessive drinking. We discovered that mGlu5 signaling in the BNST is linked to excessive alcohol consumption in a manner distinct from behavioral or neuropharmacological endophenotypes that have been previously implicated as triggers for heavy drinking. Our studies demonstrate that, in male mice, a history of chronic binge alcohol-drinking elevates BNST levels of the mGlu5-scaffolding protein Homer2 and activated extracellular signal-regulated kinase (ERK) in an adaptive response to limit alcohol consumption. Male and female transgenic mice expressing a point mutation of mGlu5 that cannot be phosphorylated by ERK exhibit excessive alcohol-drinking, despite greater behavioral signs of alcohol intoxication and reduced anxiety, and are insensitive to local manipulations of signaling in the BNST. These transgenic mice also show selective insensitivity to alcohol-aversion and increased novelty-seeking, which may be relevant to excessive drinking. Further, the insensitivity to alcohol-aversion exhibited by male mice can be mimicked by the local inhibition of ERK signaling within the BNST. Our findings elucidate a novel mGluR5-linked signaling state within BNST that plays a central and unanticipated role in excessive alcohol consumption.

SIGNIFICANCE STATEMENTThe bed nucleus of the stria terminalis (BNST) is part of the limbic-hypothalamic system important for behavioral responses to stress and alcohol, and glutamate transmission within BNST is implicated in the neurobiology of alcoholism. The present study provides evidence that a history of excessive alcohol drinking increases signaling through the metabotropic glutamate receptor 5 (mGlu5) receptor within the BNST in an adaptive response to limit alcohol consumption. In particular, disruption of mGlu5 phosphorylation by extracellular signal-regulated kinase within this brain region induces excessive alcohol-drinking, which reflects a selective insensitivity to the aversive properties of alcohol intoxication. These data indicate that a specific signaling state of mGlu5 within BNST plays a central and unanticipated role in excessive alcohol consumption.
Heterogeneity of Activity-Induced Sodium Transients between Astrocytes of the Mouse Hippocampus and Neocortex: Mechanisms and Consequences
Authors: Ziemens Daniel , Oschmann Franziska , Gerkau Niklas J. , Rose Christine R.
Published: February 2019

Activity-related sodium transients induced by glutamate uptake represent a special form of astrocyte excitability. Astrocytes of the neocortex, as opposed to the hippocampus proper, also express ionotropic glutamate receptors, which might provide additional sodium influx. We compared glutamate-related sodium transients in astrocytes and neurons in slices of the neocortex and hippocampus of juvenile mice of both sexes, using widefield and multiphoton imaging. Stimulation of glutamatergic afferents or glutamate application induced sodium transients that were twice as large in neocortical as in hippocampal astrocytes, despite similar neuronal responses. Astrocyte sodium transients were reduced by ∼50% upon blocking NMDA receptors in the neocortex, but not hippocampus. Neocortical, but not hippocampal, astrocytes exhibited marked sodium increases in response to NMDA. These key differences in sodium signaling were also observed in neonates and in adults. NMDA application evoked local calcium transients in processes of neocortical astrocytes, which were dampened upon blocking sodium/calcium exchange (NCX) with KB-R7943 or SEA0400. Mathematical computation based on our data predict that NMDA-induced sodium increases drive the NCX into reverse mode, resulting in calcium influx. Together, our study reveals a considerable regional heterogeneity in astrocyte sodium transients, which persists throughout postnatal development. Neocortical astrocytes respond with much larger sodium elevations to glutamatergic activity than hippocampal astrocytes. Moreover, neocortical astrocytes experience NMDA-receptor-mediated sodium influx, which hippocampal astrocytes lack, and which drives calcium import through reverse NCX. This pathway thereby links sodium to calcium signaling and represents a new mechanism for the generation of local calcium influx in neocortical astrocytes.

SIGNIFICANCE STATEMENTAstrocyte calcium signals play a central role in neuron–glia interaction. Moreover, activity-related sodium transients may represent a new form of astrocyte excitability. Here we show that activation of NMDA receptors results in prominent sodium transients in neocortical, but not hippocampal, astrocytes in the mouse brain. NMDA receptor activation is accompanied by local calcium signaling in processes of neocortical astrocytes, which is augmented by sodium-driven reversal of the sodium/calcium exchanger. Our data demonstrate a significant regional heterogeneity in the magnitude and mechanisms of astrocyte sodium transients. They also suggest a close interrelation between NMDA-receptor-mediated sodium influx and calcium signaling through the reversal of sodium/calcium exchanger, thereby establishing a new pathway for the generation of local calcium signaling in astrocyte processes.
Regional Delta Waves In Human Rapid Eye Movement Sleep
Authors: Bernardi Giulio , Betta Monica , Ricciardi Emiliano , Pietrini Pietro , Tononi Giulio , Siclari Francesca
Published: February 2019

Although the EEG slow wave of sleep is typically considered to be a hallmark of nonrapid eye movement (NREM) sleep, recent work in mice has shown that slow waves can also occur in REM sleep. Here, we investigated the presence and cortical distribution of negative delta (1–4 Hz) waves in human REM sleep by analyzing high-density EEG sleep recordings obtained in 28 healthy subjects. We identified two clusters of delta waves with distinctive properties: (1) a frontal-central cluster characterized by ∼2.5–3.0 Hz, relatively large, notched delta waves (so-called “sawtooth waves”) that tended to occur in bursts, were associated with increased gamma activity and rapid eye movements (EMs), and upon source modeling displayed an occipital-temporal and a frontal-central component and (2) a medial-occipital cluster characterized by more isolated, slower (<2 Hz), and smaller waves that were not associated with rapid EMs, displayed a negative correlation with gamma activity, and were also found in NREM sleep. Therefore, delta waves are an integral part of REM sleep in humans and the two identified subtypes (sawtooth and medial-occipital slow waves) may reflect distinct generation mechanisms and functional roles. Sawtooth waves, which are exclusive to REM sleep, share many characteristics with ponto-geniculo-occipital waves described in animals and may represent the human equivalent or a closely related event, whereas medial-occipital slow waves appear similar to NREM sleep slow waves.

SIGNIFICANCE STATEMENTThe EEG slow wave is typically considered a hallmark of nonrapid eye movement (NREM) sleep, but recent work in mice has shown that it can also occur in REM sleep. By analyzing high-density EEG recordings collected in healthy adult individuals, we show that REM sleep is characterized by prominent delta waves also in humans. In particular, we identified two distinctive clusters of delta waves with different properties: a frontal-central cluster characterized by faster, activating “sawtooth waves” that share many characteristics with ponto-geniculo-occipital waves described in animals and a medial-occipital cluster containing slow waves that are more similar to NREM sleep slow waves. These findings indicate that REM sleep is a spatially and temporally heterogeneous state and may contribute to explaining its known functional and phenomenological properties.
Identification and Functional Testing of Novel Interacting Protein Partners for the Stress Sensors Wsc1p and Mid2p ofSaccharomyces cerevisiae
Authors: Santiago-Cartagena Ednalise , González-Crespo Sahily , Vélez Vladimir , Martínez Nelson , Snider Jamie , Jessulat Matthew , Aoki Hiroyuki , Minic Zoran , Akamine Pearl , Mejías Inoushka , Pérez Luis M , Rymond Brian C , Babu Mohan , Stagljar Igor , Rodríguez-Medina José R
Published: February 2019

Wsc1p and Mid2p are transmembrane signaling proteins of cell wall stress in the budding yeast Saccharomyces cerevisiae. When an environmental stress compromises cell wall integrity, they activate a cell response through the Cell Wall Integrity (CWI) pathway. Studies have shown that the cytoplasmic domain of Wsc1p initiates the CWI signaling cascade by interacting with Rom2p, a Rho1-GDP-GTP exchange factor. Binding of Rom2p to the cytoplasmic tail of Wsc1p requires dephosphorylation of specific serine residues but the mechanism by which the sensor is dephosphorylated and how it subsequently interacts with Rom2p remains unclear. We hypothesize that Wsc1p and Mid2p must be physically associated with interacting proteins other than Rom2p that facilitate its interaction and regulate the activation of CWI pathway. To address this, a cDNA plasmid library of yeast proteins was expressed in bait strains bearing membrane yeast two-hybrid (MYTH) reporter modules of Wsc1p and Mid2p, and their interacting preys were recovered and sequenced. 14 previously unreported interactors were confirmed for Wsc1p and 29 for Mid2p. The interactors’ functionality were assessed by cell growth assays and CWI pathway activation by western blot analysis of Slt2p/Mpk1p phosphorylation in null mutants of each interactor under defined stress conditions. The susceptibility of these strains to different stresses were tested against antifungal agents and chemicals. This study reports important novel protein interactions of Wsc1p and Mid2p that are associated with the cellular response to oxidative stress induced by Hydrogen Peroxide and cell wall stress induced by Caspofungin.
Ion Channel Contributions to Wing Development inDrosophila melanogaster
Authors: George Laura Faith , Pradhan Sarala Joshi , Mitchell Danae , Josey Megan , Casey Justin , Belus Matthew T , Fedder Karlie N , Dahal Giri Raj , Bates Emily Anne
Published: February 2019

During morphogenesis, cells communicate with each other to shape tissues and organs. Several lines of recent evidence indicate that ion channels play a key role in cellular signaling and tissue morphogenesis. However, little is known about the scope of specific ion-channel types that impinge upon developmental pathways. The Drosophila melanogaster wing is an excellent model in which to address this problem as wing vein patterning is acutely sensitive to changes in developmental pathways. We conducted a screen of 180 ion channels expressed in the wing using loss-of-function mutant and RNAi lines. Here we identify 44 candidates that significantly impacted development of the Drosophila melanogaster wing. Calcium, sodium, potassium, chloride, and ligand-gated cation channels were all identified in our screen, suggesting that a wide variety of ion channel types are important for development. Ion channels belonging to the pickpocket family, the ionotropic receptor family, and the bestrophin family were highly represented among the candidates of our screen. Seven new ion channels with human orthologs that have been implicated in human channelopathies were also identified. Many of the human orthologs of the channels identified in our screen are targets of common general anesthetics, anti-seizure and anti-hypertension drugs, as well as alcohol and nicotine. Our results confirm the importance of ion channels in morphogenesis and identify a number of ion channels that will provide the basis for future studies to understand the role of ion channels in development.
La geopolítica en la Península Coreana
Authors: Solórzono Tello Octavio Alonso , Portador García Teresa de Jesús
Published: February 2019

El artículo examina y analiza la geopolítica en la Península Coreana, enlazando analíticamente los elementos globales, interregionales, regionales y estatales, de tal suerte, que permite explicar cómo se está reconfigurando geopolíticamente el poder global y cómo se están reposicionando Estados Unidos, Rusia y China en Asia Pacífico, con el fin de tener mayor injerencia y control, aprovechando la pérdida de liderazgo de Estados Unidos en la región para posicionarse como líderes mundiales. Por otro lado, aborda los acercamientos entre Corea del Norte y Corea del Sur para una posible solución del conflicto. Estas dinámicas tienen un impacto en la reconfiguración del orden global, el cual tiende a ser multipolar, pero al mismo tiempo incrementa la inestabilidad, el riesgo global y la violencia, poniendo en duda la gobernanza global.
Empatía y tacto pedagógico profesional: ¿un saber pedagógico y humanista?
Authors: Müller-Using Susanne
Published: February 2019

Esta contribución examina la importancia educacional de la empatía, con base en el estado del arte de la investigación interdisciplinaria. La causa de esta discusión es la percepción de una falta de empatía vivida en la sociedad. La metodología aplicada se fundamenta en soportes científicos e investigaciones del comportamiento de las personas. Más aún, este trabajo trata de la experiencia de ser un educador y, por consiguiente, de la tarea que implica trabajar con niños y adolescentes. Además, el artículo se enfoca en la discusión del cómo y el porqué de la empatía en la personas, tomando en cuenta la historia y la actualidad. Además habla de cómo la empatía podría ser un elemento importante en cuestiones pedagógicas de la educación en valores para niños y adolescentes, ya que la empatía incrementa la confianza en el propio proceso de aprendizaje que fortalece la confianza en el marco de las relaciones interpersonales. Asimismo, el artículo describe el tacto pedagógico y la empatía como actitudes que se complementan y resultan igual de importantes para el desarrollo, aprendizaje y la formación de un niño.
Co-crystal of carbazole-based thiourea derivative compound with acetic acid: Crystallography and Hirshfeld surface analysis
Authors: GUMUS İlkay
Published: February 2019

Co-crystal of the N,N´-(((3,6-dichloro-9H-carbazole-1,8-diyl)bis(azanediyl))bis(carbonothioyl))bis(2,2-dimethylpropanamide)
as a carbazole-based thiourea derivative (CBT) with acetic acid (AcOH) was
prepared and its molecular structure examined using
the single crystal X-ray diffraction study and the Hirshfeld surface analysis.
This co-crystal was designed to explore the supramolecular synthons and
intermolecular interactions diversity between the components of co-crystal. The
analysis of the crystal structure and packing revealed that the CBT:AcOH co-crystal
are formed by a strong O–H⋯S and
C-H···O hydrogen bonding interactions between components of
co-crystal. In addition, its’ structure is further stabilized by strong C-H···π
stacking interactions and N-H···O and N-H···S homosynthons
between CBT molecules. The Hirshfeld surfaces and associated two-dimensional fingerprint plots of the
co-crystal were also analyzed to clarify the nature of the hydrogen bond
interactions and close intermolecular interactions in the crystal structure.
The Hirshfeld surfaces and the associated two-dimensional fingerprint plots
analysis revealed that the majority of close contacts forming supramolecular
structure were associated with relatively weak interactions such as H···H, C···H and N···H. So, it can be said that these interactions play a major role
in molecular crystal packing.
Monte Carlo Evaluation of the Methods Estimating Structural Change Point in Panel Data
Authors: DAĞLIOĞLU Selim , BAKIR Mehmet Akif
Published: February 2019

In this study, we investigate the existence of
structural break in a panel data consisting of N time series of T unit length,
and the estimation performance of Simple Mean Shift Model, Fluctuation Test,
Wald Statistic Test, Kim Test which are based on common break assumption are
examined to determine the break date. In this context, 108 Monte Carlo
simulations are performed, each of which consisted of 3000 repetitions for the
factors number of cross-sections, time dimension, break size and break rate
factors, which are considered to influence the performance of the tests. As a
result of the Monte Carlo simulations, the Simple Mean Shift Model approach
predicts the break point with a higher performance than the other methods. In
addition, if the breakpoints are at the midpoint of the series, the Wald
Statistic and Kim Tests show the highest performances, while the Fluctuation
Test shows the highest breakpoint predictive performance if break occur in the
third quarter of the series. Generally, as the number of cross-sections
increases, the estimation performance of the tests increases, whereas as the
time dimension increases, the performance of methods other than the Simple Mean
Shift Model decreases. As a final point, it has been observed that there is no significant
effect of the break size on the predictive performance of the methods.
Controlled Laboratory Experiments on Radon Diffusion Coefficient
Authors: İÇHEDEF Mutlu
Published: February 2019

Radon which occurs in
uranium decay series is a noble gas and it moves from the deeper layers of the
earth crust to the atmosphere. Formation of the radon gas in the Earth's crust
and its migration to atmosphere are quite complex process because of too many
factors. In this process, both the advection and diffusion are effective
mechanisms on radon transport. But mostly the dominant mechanism is diffusion.
In this study, radon diffusion of soils taken from Küçük Menderes Basin was
investigated by controlled laboratory experiments and the radon diffusion
coefficient of these soils were calculated
Polypyrrole Modified Graphite Electrode for Supercapacitor Application: The Effect of Cycling Electrolytes
Authors: YAVUZ Abdulcabbar , AKTAŞ Sıtkı , DURDU Salih
Published: February 2019

Graphite
electrode was modified by polypyrrole (PPy) thin film. PPy was electrodeposited
potentiostatically by applying -1.5 V from acidic aqueous solution having
pyrrole monomers. The waiting time of deposition solution effect the surface
coverage of resulted films. PPy modified electrodes fabricated by old solution
have lower surface coverage than PPy obtained from freshly prepared solution.
PPy films were transferred to aqueous (acidic, neutral, alkaline) and a non-aqueous
(Deep Eutectic Solvent) solutions for cycling. Capacitance performance of PPy
film in a choline chloride based ionic liquid (Ethaline) was compared with that
of PPy films in aqueous solutions. As PPy film in salt solution (LiClO4
and NaCl) was evolved because deposition electrolyte was different (H2SO4)
than deposition electrolyte and salt ions are exchanged at the beginning of
cycling. Film obtained in acidic media was transferred into alkaline solution
or ionic liquid is electroinactive. PPy film is strongly electroactive in an
acidic media for hundreds of cycles as acidic media can cause the highest
charge which is directly related to capacitive performance. Upon increasing pH
value of cycling electrolyte, current and charge value decreases. PPy film in a
salt solution (NaCl or LiClO4 in water) and acidic solution (H2SO4)
is electroactive and can be used for supercapacitor application. As PPy film in
ionic liquids and alkaline solution cannot be electroactive, they cannot be
used for supercapacitor applications. Capacity retention of PPy in KOH and
Ethaline is low (around 5%). However, PPy thin film in H2SO4
has 77% of capacitance retention after 500 scans.
Utilização do diodo emissor de luz (led) na cicatrização de queimaduras: revisão sistemática da literatura
Authors: Araújo Marlise de Jesus Santos , Martins Gabriela Botelho
Published: February 2019

INTRODUÇÃO: O tratamento de vítimas de queimadura é desafiador pela gravidade da própria lesão e das complicações que podem ocorrer durante o processo de cicatrização. A fisioterapia dermatofuncional tem atuação no tratamento de cicatrizes, utilizando de terapias para acelerar o processo cicatricial e recuperação funcional adequada. O diodo emissor de luz ou LED tem sido descrita como uma possibilidade terapêutica valiosa para fisioterapia com o intuito de reduzir complicações funcionais e estéticas em processos cicatriciais de indivíduos queimados.  OBJETIVOS: Revisar a literatura acerca da utilização da luz LED e seus efeitos na cicatrização tecidual na lesão por queimadura. MATERIAIS E MÉTODOS: Trata-se de uma revisão sistemática da literatura, realizada no mês de agosto de 2017, utilizando as bases de dados Bireme, PubMed e PeDro, baseado nos critérios PRISMA. Foram incluídos no estudo os artigos que abordassem a utilização do LED na cicatrização específica de queimaduras, publicados nos últimos cinco anos (2012 -2017), nos idiomas inglês e português. Os critérios de exclusão foram artigos que abordaram o uso do LED na cicatrização tecidual em geral. A seleção dos artigos foi realizada por dois autores, não havendo consenso entre ambos, um terceiro autor seria convocado, o que não foi necessário nesta busca. RESULTADOS: Foram encontrados 1.029 artigos na busca, destes foram incluídos 04 artigos, que abordaram a utilização do LED na cicatrização específica de queimaduras publicados de 2012 a 2017. Todos os estudos encontraram melhoras do processo cicatricial com uso do LED, mesmo sendo utilizados comprimentos de onda distintos nos trabalhos analisados. CONCLUSÃO: A utilização do LED no tratamento de queimaduras demonstrou favorecer o processo de cicatrização tecidual em animais e melhorar os aspectos histológicos nos tecidos tratados, porém ainda pouco utilizado na Fisioterapia.
Taking signals seriously
Authors: Baysan Alper
Published: February 2019

While researchers broadly agree that a credible EU membership perspective is vital for effective rule transfer to candidate countries, scholarship has so far conceived of membership credibility in formal and dichotomous terms. This is emblematic in the empirical focus on accession stages or types of EU incentives. As a result, the literature has not taken seriously the role of political signals shaping credibility perceptions. This article develops and systematically tests a novel argument: the credibility of the EU’s membership hinges on whether a given country believes in the EU’s ability to deliver on its promise. As such, I opt for conceiving of membership credibility as a perceptive issue. Specifically, it is argued that credibility perceptions are influenced by official EU announcements as they are by political signals from the big three (France, the UK and Germany). The argument finds empirical corroboration in a pooled regression analysis based on an original dataset of rule transfer from the acquis communautaire comprising 16 candidate countries from 1998 to 2009. While future research should assess the veracity of the hypothesis across countries and time, at the very minimum, the findings suggest to take the issue of conflicting political signals more seriously when gauging the EU’s membership credibility.
Pegida
Authors: Kocyba Piotr
Published: February 2019

The following paper will discuss whether Pegida participants can be accused of having extreme right-wing attitudes or, on the contrary, the movement should be acknowledged as a legitimate form of protest by ‘concerned citizens’. To answer this question, the paper will refer to data collected at demonstrations and to general population polls. It transpires, despite other claims (also formulated by experts on Pegida), that Pegida demonstrators indeed lean sharply to the extreme right of the political spectrum. This is indicated both by the party’s electoral preferences (after all, a vast majority of the protesters would vote for the AfD) and the worldview of Pegida’s supporters that indicates their proximity to the extreme right.
Az Daha Fazladır: Dijital Seyir Platformlarının Tüketim Kültürü Açısından İzleyicilerin Seyir Alışkanlıklarına Olan Etkisi
Authors: DİKER Can
Published: February 2019

Dijital yayıncılığın teknik altyapısının gelişmesinin ardından çevrimiçi seyir platformları, 2010 yılı
sonrasında Türkiye’de giderek yaygınlaşmışlardır. Bu platformlar gerek televizyonlardaki gerekse
tablet ve telefonlardaki uygulamalar aracılığıyla geleneksel televizyon ve film/dizi anlayışından
farklı bir seyir tecrübesini kullanıcılarına sunmaya başlamışlardır. Biçim ve içerik olarak farklılaşan
seyir deneyimlerinde, izlenilen içeriğin süresinin uzunluğunun değişimi ya da tıpkı dizi mantığında
olduğu gibi parçalı hale geldiğinde kısa bölümlerden oluşup büyük bir içerik yaratırken izleyicinin
kendi seyir hızını ayarlayabilmesi olanağı, en belirgin teknolojik özelliklerden olmaktadır.
1980’lerden sonra giderek etkisini gösteren tüketim kültürü ile birlikte yeni nesilde uzun süreli
film ya da dizilere, romanlara, hatta cümlelere dahi olan tahammülün azalması sonucu, dijital
platformlar da bu durumu göz önünde bulundurarak yeni neslin tüketim alışkanlıklarına göre
kendilerini biçimlendirmektelerdir. Bu durum, iki saat üzerinde süren dizilerin ve filmlerin tercihen
daha az tüketilmesi ihtimaline yol açmaktadır. Bu çalışmada, YouTube ile başlayarak alternatif bir
seyir tecrübesini deneyimleyen genç kuşak bireylerin, günümüzde Netflix, Puhutv, BluTV, Hulu
vb. dijital platformları ne sıklıkla kullandığına ve bu platformlardan beklediği özgün içeriğin
biçimsel özelliklerinin ne olduğuna yönelik bir anket çalışması yapılacaktır. Anket çalışmasının
ulaşılabilir evrenini, İstanbul ili içerisinde üniversitelerin iletişim fakültelerinde eğitim görmekte
olan öğrenciler oluşturacaktır. Bu evren sınırları dâhilinde İstanbul’daki iki devlet ve iki vakıf
üniversitesinin İletişim Fakülteleri bünyesinde 29 yaş altı yaklaşık yüz kişilik bir öğrenci grubuna
‘tipik örnekleme yöntemi’ uygulanacak olup, çalışmanın sonuçları İstanbul ilindeki modern tüketim
biçimleriyle yetişip onu benimsemiş, küreselleşme ile uyumlu ve kent kültürünü içinde bulunan
bir toplumsal gruba dair bulgular olarak kabul edilecektir. Ardından anket sonuçları, uzun süreli
dikkat gerektiren materyale tahammülsüzlüğün oluştuğu hipotezi üzerinden, tüketim kültürü ve
seyir deneyimleri arasındaki ilişki bağlamında değerlendirilecektir. Bu bağlamda günümüzde uzun
metraj yapımlardan ziyade kısa ve orta metraj yapımların daha popülerleşmesi ve bu durumun
gelecekteki yapımcılık anlayışına olan etkisi ele alınacaktır.
SOIL EROSION INDICATION BY MAGNETIC METHODS IN KHARKIV REGION
Authors: Kruglov O. , Menshov O. , Ulko E. , Kucher A. , Nazarok P.
Published: February 2019

The new land regulation system in Ukraine, as well as European integration strategy, require to update the methodological approaches of farming land monitoring, increasing the accuracy of research and reducing the cost of the studies. Among such effective tools is soil magnetism application to study the erosion processes. The introduction of magnetic methods at the technology level is associated with methodological problems: density of the sampling network, the reliability of the statistics. The object of the research was soil erosion processes at the territory of Rusko-Tishkivska land council (Kharkiv region). Field, statistical, laboratory, and cartographic methods were used. The parameters of magnetic susceptibility (MS) and humus content (G) were obtained for soil samples from three genetic horizons of the sections (the depth is 0–10, 10–20 and 25–40 cm). A sequence of indicators was formed, the numerical values of MS 1, MS 2, MS 3, and G 1, G 2, G 3 were systematized. The humus content index is characterized by a greater degree of variation than the magnetic susceptibility. The sample data has a more dense distribution than the humus content in all horizons of the soil. Comparison of the studied indicators with respect to the magnitude of the relative sampling error established that more reliable results are observed for magnetic susceptibility. The maximum sampling errors for all horizons of the soil are lower than for the humus content. The article widely considers the statistical tests to check the homogeneity of the collection of selected field data. According to the Cramer–Welch T criterion, the homogeneity of the mathematical expectation is satisfied for all samples except MS 3. The correlation analysis of the samples showed that the small coefficients of rank correlation of Spearman were found in the pair of G 1 and MC 1, and in the pair G 1 and MC 3. The corellation is 0,697 and 0,641 respectively. Magnetic susceptibility and humus content show a high degree of correlation, which can be traced for different genetic horizons.