bluuebunny/crossref_metadata_2025 huggingface dataset:
FIRST EXPERIENCE OF USING THE BIOSIMILAR OF ORIGINAL ECULIZUMAB FOR PREVENTION OF ATYPICAL HEMOLYTIC-UREMIC SYNDROME RECURRENCE AFTER RENAL TRANSPLANTATION IN A CHILD
Authors:   Department of Children's Diseases No. 1 of the Belarusian State Medical University, Minsk, Republic of Belarus, Baiko S.V.
Published: January 2021

The article presents a clinical case of atypical hemolytic uremic syndrome (аHUS), the debut of which proceeded under the guise of a typical HUS. After 4 months of hemodialysis, the child did not need renal replacement therapy for the next 9 months. The development of end-stage renal failure required a molecular genetic study to clarify the diagnosis. The child has mutations in the genes of the complement regulatory proteins – factor I and MCP. The risk of aHUS recurrence with these genes mutations to a renal transplant without pathogenetic prophylaxis is up to 80%. The use of the Russian biosimilar eculizumab before and after kidney transplantation allowed to prevent the activation of complement and disease recurrence to transplanted organ.
PECULIARITIES OF THE RADIATION PATTERN OF THE BRAIN AND INTERNAL ORGANS OF NEWBORNS WHO UNDERWENT SEVERE PERINATAL ASPHYXIA AND UNDERWENT GENERAL THERAPEUTIC HYPOTHERMIA, ACCORDING TO THE PILOT STUDY RESULTS
Authors:   Kursk State Medical University, Kursk, Russia, Vorotyntseva N.S. ,   Kursk Oblast Regional Perinatal Center, Kursk, Russia, Orlova V.V. ,   Kursk State Medical University, Kursk, Russia, Motina A.N. ,   Kursk State Medical University, Kursk, Russia, Novikova A.D. ,   Kursk State Medical University, Kursk, Russia
Published: January 2021

Objective of the research: to study the features of the radiological picture of the brain and internal organs of newborns with severe perinatal asphyxia, who underwent general therapeutic hypothermia (GTH). Materials and methods: the study included 116 newborns with severe perinatal asphyxia. GTH was performed in 72 patients (group 1), 44 children did not receive hypothermia in the 2 (control) group. In the first 6 hours of life, children of groups 1 and 2 underwent ultrasound of the brain and abdominal organs and chest x-ray. The complex ultrasound scan was repeated at 3–5, 7–10, 14–16 and 21–28 days. Repeated chest x-ray was carried out strictly according to the indications. Results: GTH reduced the incidence of organic brain lesions by 18% in children with severe perinatal asphyxia (p0,05). The study revealed a number of undesirable consequences associated with GTH. Transient effusion into the abdominal and thoracic cavities was diagnosed by ultrasound in 8 (11%) patients after hypothermia, while there were no such changes in children in the control group (p<0,05). X-ray of the chest in newborns who received GTH during the first 14 days revealed edematous-hemorrhagic changes in the lungs more often than in patients of the control group – 55 (76%) and 24 (55%), respectively (p<0,05). Conclusions: GTH effectively prevented the development of severe post-hypoxic changes in the brain. The negative effect of hypothermia on microcirculation was manifested by the development of effusion into the serous cavities and edematous-hemorrhagic syndrome.
SYNDROME OF INTRACRANIAL HYPERTENSION AND IRON DEFICIENCY IN INFANTS WITH CEREBRAL ISCHEMIA IN THE NEONATAL PERIOD
Authors:   Kazan State Medical University, Kazan, Republic of Tatarstan, Russia, Gaynetdinova D.D. , Galeeva D.F. ,   Kazan State Medical University, Kazan, Republic of Tatarstan, Russia
Published: January 2021

Objective of the research: to study the relationship between severity of clinical manifestations of intracranial hypertension (ICH) syndrome of perinatal genesis and red blood counts in infants who underwent cerebral ischemia (CI) at birth. Materials and methods: 94 children with ICH syndrome of perinatal posthypoxic genesis at the age of 6 months of corrected age were examined: 1st group – with normal hemoglobin (Hb) level, 32 children (34%); 2nd group – with reduced Hb level, 62 children (66%). Researchers used anamnestic, clinico-neurological (assessment of the somatic and neurological status with objectification of ICH severity using a specially developed 60-point «Assessment of intracranial hypertension severity» (AIHS) scale in children aged 1 month to 1 year), laboratory study of Hb level on an automated hematological analyzer Sysmex XE2100, Sysmex, Germany, and ferritin level on a modular analytical system Сobas8000, Roche, Denmark) and statistical methods of research. Results: 77% of children (72 children) were diagnosed with mild ICH, 22% (21 children) had moderate severity, and one child (1%) had severe ICH. A strong negative relationship was obtained between the severity of ICH syndrome (the number of points on AIHS scale) and the Hb level (R=–0,72): the lower the Hb level, the more pronounced the clinical manifestations of the ICH syndrome. The ferritin content turned out to be reduced in 83% (78 children), an average negative correlation was found between the severity of the ICH syndrome (the number of points on AIHS scale and ferritin values (R=–0,55): the lower the ferritin content in the blood, the more severe the clinical manifestations of ICH syndrome. Conclusion: in infants with ICH syndrome in the residual period of neonatal IC, a relationship was found between the severity of clinical and instrumental manifestations of ICH syndrome with red blood parameters (Hb and serum ferritin). In this regard, the participation of latent iron deficiency in the pathophysiological processes of the formation and course of ICH syndrome in infants is not excluded.
EARLY AGE ARTERIAL ISCHEMIC STROKE ASSOCIATED WITH MINERALIZING LENTICULOSTRIATAL ANGIOPATHY AND MILD TRAUMATIC BRAIN INJURY
Authors:   Russian Medical Academy for Continuous Professional Education, Moscow, Russia, Komarova I.B. , Zykov V.P. ,   Russian Medical Academy for Continuous Professional Education, Moscow, Russia
Published: January 2021

Study aims: 1) to evaluate the significance of mineralizing angiopathy of lenticulostriate arteries (MALA) in the development of arterial ischemic stroke (AIS) in children; 2) to study clinical and neuroimaging signs of AIS that develops after a head injury and does not meet the criteria of known disease types. Material and methods: to achieve the first aim, groups were formed: 1) the main group – patients with AI, n=86, Me 2,9 years; control – healthy children, n=131, Me 3,2 years. In the compared groups, neurosonography (NSG) protocols were studied for MALA. For the second aim, anamnesis and data from a clinical neuroimaging examination of 106 patients with AIS (Me 2,9 years) were analyzed. Stroke type was identified by the Childhood Arterial Ischemic Stroke Standardized Classification and Diagnostic Evaluation (CASCADE). Results: MALA increases the risk of AIS (ОR 16,15 [95% CI 5,43–48,1]). Stroke that does not meet the criteria of 1–5 types according to CASCADE is often associated with MALA. Clinical of AIS in patients with MALA are early age and mild head trauma (F=6,9, R=0,73, p<0,0001); the onset is marked by the absence of fever, vomiting, seizures, Glasgow coma scale 13, improvement in the first week (F=8,49, R=0,546, p<0,0001). Neuroimaging signs are the basal ganglia lacunar infarct and the absence of cerebral arteriopathy according to magnetic resonance angiography (F=52,8, R=0,402, p<0,0001). The percentage of this type stroke in children with AIS is 26,4%. Conclusion: MALA is a risk factor of AIS in children. AIS in infants which is associated with mineralizing angiopathy of lenticulostriate arteries and mild head trauma is an independent type of stroke. For its verification, computed tomography or NSG are needed.
FACTORS THAT DETERMINE THE OUTCOME OF PREGNANCY AND HEALTH OF CHILDREN BORN TO WOMEN WITH GENITOURINARY SYSTEM DISEASES USING ASSISTED REPRODUCTIVE TECHNOLOGIES
Authors:   Urals State Medical University, Yekaterinburg, Sverdlovsk Oblast, Russia, Plaksina A.N. , Kovtun O.P. ,   Urals State Medical University, Yekaterinburg, Sverdlovsk Oblast, Russia, Sinotova S.L. ,   Ural Federal University named after the first President of Russia B.N. Yeltsin, Yekaterinburg, Sverdlovsk Oblast, Russia, Limanovskaya O.V. ,   Ural Federal University named after the first President of Russia B.N. Yeltsin, Yekaterinburg, Sverdlovsk Oblast, Russia, Makutina V.A. ,   Family Medicine Center Joint Stock Company, Yekaterinburg, Sverdlovsk Oblast, Russia
Published: January 2021

Objective of the research: identification of risk factors that potentially affect the outcomes of pregnancies achieved by assisted reproductive technologies (ART), with an assessment of the health status of children born to women with genitourinary system (GUS) diseases. Materials and methods: a retrospective uncontrolled non-randomized multicenter study of 821 women and 836 children under the age of 3 years. Results: gynecological history of women has little effect on pregnancy outcomes achieved by ART (Matthews coefficient <0,2). Children born to mothers with GUS diseases are statistically significantly more likely to have some infectious and parasitic diseases (p=0,0002), mental and behavioral disorders (p=0,009), diseases of the nervous system (p=0,031), respiratory system (p=0,009), oral cavity, salivary glands and digestion (p=0,002), musculoskeletal system and connective tissue (p=0,001), genitourinary system (p=0,009), certain conditions arising in the perinatal period (p=0,009), as well as trauma, poisoning, and some other consequences of external causes (p=0,009) than children from mothers without GUS diseases. Conclusion: children born by ART from women with GUS pathology are a risk group for the development of diseases in early age.
HOLTER ECG AND RESPIRATORY CURVE MONITORING IN NEWBORNS WITH CONGENITAL HEART DISEASE: PILOT CASE–CONTROL STUDY
Authors:   National Scientific and Practical Center for Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Moscow, Russia, Rybalko N.A. , Korableva N.N. ,   Pitirim Sorokin Syktyvkar State University, Syktyvkar, Komi Republic, Russia, Kotlukova N.P. ,   Pirogov Russian National Research Medical University, Moscow, Russia, Makarov L.M. ,   Central Children’s Clinical Hospital of the Russian Federal Biomedical Agency, Moscow, Russia,   Academy of Postgraduate Education with the Federal Research and Clinical Center of the Russian Federal Biomedical Agency, Moscow, Russia, Kemaev D.A. ,   N.P. Ogarev Mordovia State University, Saransk, Republic of Mordovia, Russia
Published: January 2021

Objective of the research: analysis of 24-hour ECG indicators with the search for heart rhythm disorders in children with congenital heart defects (CHD) during preparation for surgical correction of heart disease; determination of the number of apnea and periodic breathing (PB) episodes in children with CHD based on the daily pneumogram analysis. Materials and methods: 24-hour ECG monitoring with pneumogram (respiratory curve) recording was performed in 37 newborns in the late neonatal period, on the 13th [10; 16] (Me [95% CI]) day of life. Inclusion criteria: uncorrected congenital heart disease complicated by heart failure (HF) of functional class II – III according to R.D. Ross, and/or arterial hypoxemia. The group included patients whose heart disease hemodynamics did not require urgent or emergency cardiac surgery. The study was performed during the planned preparation for surgical treatment in somatic department. In CHD structure combined heart defects prevailed. Two children with tetralogy of Fallot had only arterial hypoxemia. The comparison group included 73 healthy full-term newborns examined in the early neonatal period – on the 2nd [2; 3] (Me [95% CI]) day of life before discharge. Researchers analyzed the heart rate (HR) during sleep and wakefulness, circadian index, heart rate variability (HRV), the frequency of heart rhythm disorders, the number and duration of apnea and PD episodes. Results and discussion: there was a significantly lower number of PD and sleep apnea episodes in newborns with hemodynamically significant CHD; parameters of HRV and heart rate in children with CHD are characterized by a high level of activity of nervous system sympathetic part due to a severe degree of HF and/or arterial hypoxemia; cardiac arrhythmias in newborns with CHD were represented by a rare single extrasystole.
BIOLOGICAL ROLE OF ERYTHROPOIETIN IN THE PERINATAL PERIOD: NON-ERYTHROPOIETIC FUNCTIONS IN HYPOXIC-ISCHEMIC LESIONS OF THE CENTRAL NERVOUS SYSTEM
Authors:   Scientific and Research Institute for Obstetrics and Pediatrics of the Ministry of Healthcare of Russia with the Rostov State Medical University, Rostov-on-Don, Russia, Berezhanskaya S.B. , Lukianova E.A. ,   Scientific and Research Institute for Obstetrics and Pediatrics of the Ministry of Healthcare of Russia with the Rostov State Medical University, Rostov-on-Don, Russia, Abduragimova M.K. ,   Scientific and Research Institute for Obstetrics and Pediatrics of the Ministry of Healthcare of Russia with the Rostov State Medical University, Rostov-on-Don, Russia
Published: January 2021

Erythropoietin is recognized as a pluripotent glycoprotein with unique biochemical and epigenetic properties that are important for fetal growth and development, as well as in critical conditions in subsequent periods of ontogenesis. In recent decades, researchers and clinicians have increased interest in the problem of the biological significance of erythropoietin, which can form the basis for constructing algorithms for early prognosis and diagnosis, optimizing the treatment of pathology of the perinatal period, including perinatal hypoxic-ischemic damage to the brain and spinal cord, which are at risk of disability and have a risk of disability significant role in neonatology and perinatal neurology.
PERINATAL EFFECTS AND RISK OF ARTERIAL HYPERTENSION IN CHILDREN (PART 2)
Authors:   Pirogov Russian National Research Medical University, Moscow, Russia, Chugunova O.L. , Shumikhina M.V. ,   N.F. Filatov Moscow City Children's Clinical Hospital of the Moscow Department of Healthcare, Moscow, Russia, Yaroshevskaya O.I. ,   Pirogov Russian National Research Medical University, Moscow, Russia, Dumova S.V. ,   Pirogov Russian National Research Medical University, Moscow, Russia, Cherkasova S.V. ,   Pirogov Russian National Research Medical University, Moscow, Russia,   N.F. Filatov Moscow City Children's Clinical Hospital of the Moscow Department of Healthcare, Moscow, Russia, Shumilov P.V. ,   Pirogov Russian National Research Medical University, Moscow, Russia
Published: January 2021

The article presents data about maternal and prenatal influences lead to «programming» of arterial hypertension (AH) in the child's later life. A special group that is threatened by the development of AH at an older age is premature children and children with intrauterine development delay due to a small number of nephrons and the launch of prenatal programming of hypertension. The state of the mother's health before conception, as well as the use of assisted reproductive technologies, despite a normal pregnancy in general and the birth of a healthy newborn can provoke the development of hypertension in childhood.
Pendampingan Penguatan Tata Kelola Sistem Informasi Dinas Pertanian Kota Salatiga
Authors: Haspsari Aprina Nugrahesthy Sulistya , Kurnianingtyas Debora Herni , Aditya Yosua Febrian Putra , Ferosa Meike Indri
Published: January 2021

Information Systems Audit is a mechanism that aims to ensure the internal control in the internal system of an organization has been running in accordance with the design set in an effort to achieve the goals set by evaluating and testing every activity carried out in the organization. In this article, the community service activities in the form of an information system audit on the Farming System in the Department of Agriculture of Salatiga City are explained. The audit was conducted using COBIT. Based on the audit result, it was found that the information system at the Department of Agriculture of Salatiga City, which is the Pa'Tani System, has been running smoothly and is well managed according to the desired goals and needs
Pendidikan Dan Penyuluhan Kepada Masyarakat Desa Kalikurmo Kecamatan Bringin Kabupaten Semarang
Authors: Soetjipto Hartati , Riyanto Cucun Alep , Febriyanti Teresa , Putra Yoga Andika , Krisdayanti Mitra , Nurrohmah Laili
Published: January 2021

This Community Service activity is aimed at improving the quality of teaching and learning of Kalkurmo Village Elementary School children, Beringin District, Semarang Regency in the fields of Science and Mathematics. Kalikurmo Village has human resources who have low educational backgrounds, so that its residents have minimal insight and are less developed. This caused us to be moved in providing counseling to the residents of Kalikurmo Village, which if it could help add to their insight and knowledge. Activities carried out in the form of assisting classroom teaching and tutoring outside class hours. Elementary school student are helped in deepening science and mathematics material by this activity.
Pendampingan Pembuatan Media Budidaya Cacing Sutera pada Kelompok Pembudidaya Ikan di Kota Sorong
Authors: Widya Yanti Dwi Indah , Romanwati Enny , Tabalessy Roger R , Masengi Melisa Ch. , Payung Clara N.
Published: January 2021

Cacing sutera merupakan pakan alami ikan yang memiliki kandungan protein tinggi. Cacing sutera umumnya diperoleh petani ikan dari hasil tangkapan alam karena belum ada yang membudidayakan, disebabkan kurangnya pengetahuan atau keterampilan pembudidaya ikan. Kebiasaan mengandalkan cacing dari pasokan alam menyebabkan ketersediaan cacing sutera semakin sulit di pasaran. Untuk itu peningkatan kemampuan petani ikan dalam membudidayakan cacing sutera perlu dilakukan. Metode yang dilakukan dalam kegiatan pengabdian pada masyarakat adalah dengan memberikan penyuluhan sekaligus mempraktekkan pembuatan media budidaya cacing rambut. Kegiatan pengabdian pada masyarakat yang dilaksanakan dalam bentuk penyuluhan dan praktek pembuatan media untuk budidaya cacing sutera memberikan dampak positif pada kelompok pembudidaya ikan. Hal ini karena kelompok pembudidaya mendapat pengetahuan baru dan bisa mempraktekkannya dalam kegiatan budidaya yang mereka lakukan.
PROBLEM SOLVING: SUATU PENDEKATAN PEMBELAJARAN UNTUK MENINGKATKAN HASIL BELAJAR PESERTA DIDIK
Authors: Angriani Andi Dian , Nur Fitriani , Nur Rahmawati
Published: January 2021

AbstrakPenelitian ini bertujuan untuk mengetahui peningkatan hasil belajar peserta didik melalui pendekatan problem solving. Jenis penelitian yang digunakan adalah penelitian tindakan kelas yang terdiri dari dua siklus, melalui beberapa tahapan, yaitu perencanaan, pelaksanaan tindakan, observasi, dan refleksi. Subjek penelitian ini adalah siswa kelas VIII9 MTs Negeri 1 Makassar yang berjumlah 40 peserta didik. Tindakan yang diberikan adalah dengan menerapkan pendekatan problem solving. Hasil penelitian ini menunjukkan bahwa pendekatan problem solving dapat meningkatkan hasil belajar peserta didik, terlihat pada siklus I skor rata-rata hasil belajar peserta didik yaitu 79,48 dan persentase peserta didik yang memenuhi Kriteria Ketuntasan Minimal (KKM) sebesar 65%, sementara pada siklus II skor rata-rata hasil belajar peserta didik meningkat menjadi 89,40 serta persentase peserta didik yang memenuhi KKM meningkat menjadi 87,50 %. Dengan demikian, hasil belajar matematika peserta didik dapat meningkat melalui penerapan pendekatan problem solving. AbstractThis study aims to determine the improvement in student learning outcomes through a problem solving approach. The type of research used is classroom action research which consists of two cycles, through several stages, namely planning, implementing action, observing, and reflecting. The subjects of this study were 40 students of class VIII9 MTs Negeri 1 Makassar. The action given is to apply a problem solving approach. The results of this study indicate that problem solving approach can improve students' learning achievement, seen in the first cycle the average score of student learning outcomes is 79.48 and the percentage of students who meet the minimum completeness criteria is 65%, while in the second cycle the average score student learning outcomes increased to 89.40 and the percentage of students who met the minimum completeness criteria increased to 87.50%. Thus, students' mathematics learning achievement can be increased through the implementation of problem solving approach.
COOPERATIVE INTEGRATED READING AND COMPOSITION (CIRC) MODEL LEARNING PLAN IN IMPROVING ENGLISH READING SKILL
Authors: Syam Rifqi Zaeni Achmad , Indah Rosiana Nurwa , Sauri R. Supyan , Ruqayah Farah
Published: January 2021

Abstract:This study aimed to obtain an overview of the Cooperative Integrated Reading and Composition learning planning model to improve grade IX students' English reading skills at SMP Negeri 1 Jampang Tengah. The method used in this study was a descriptive method with a qualitative approach, and the research subjects were English teachers at SMP Negeri 1 Jampang Tengah. The data collection was done through document review, observation, and interviews. From the study results, it could be concluded that the Cooperative Integrated Reading and Composition Model's learning planning activities consisted of making annual programs, semester programs, syllabus, and lesson plans. In principle, it was good and appropriate to make lesson plans with the school's provisions and guidelines. Therefore, it was believed to achieve the specified competency standards and improve reading skills in English.Abstrak:Penelitian ini bertujuan untuk memperoleh gambaran tentang perencanaan pembelajaran model Cooperative Integrated Reading and Composition dalam meningkatkan keterampilan membaca bahasa Inggris siswa kelas IX di SMP Negeri 1 Jampang Tengah. Metode dalam penelitian ini menggunakan metode deskriptif dengan pendekatan kualitatif. Subjek penelitian ini adalah guru bahasa Inggris di SMP Negeri 1 Jampang Tengah. Adapun Pengumpulan data dilakukankan melalui pengkajian dokumen, observasi dan wawancara. Dari hasil penelitian, dapat disimpulkan bahwa kegiatan perencanaan pembelajaran model Cooperative Integrated Reading and Composition terdiri dari pembuatan program tahunan, program semester, silabus dan RPP. Pada prinsipnya sudah baik dan sesuai dalam pembuatan perencanaan pembelajaran dengan ketentuan dan pedoman yang di tetapkan oleh pihak sekolah. Oleh karenanya, diyakini dapat mencapai standar kompetensi yang ditentukan dan dapat meningkatkan keterampilan membaca bahasa Inggris.
CONTRIBUTION OF BANJAR ULAMA IN THE DEVELOPMENT OF ISLAMIC EDUCATION IN SAMARINDA CITY
Authors: Khojir Khojir
Published: January 2021

Abstract:Samarinda is a multi-ethnic city, and there are various urban Ulama in Samarinda such as Javanese, Banjar, Bugis, and Madurese Ulama. Urban Ulama has made a significant contribution to the development of Islam. This research specifically examined the contribution of Banjar Ulama in the development of Islamic education. The purpose of this article was to determine the contribution of Banjar Ulama to Islamic Education in Samarinda City. This research used a qualitative study with a historical-phenomenological approach. The data sources were from Banjar figures, Paguyuban Banjar, and Banjar Ulama and data collection procedures were done through in-depth interviews and documentation. Data were analyzed using qualitative analysis, namely data reduction, presentation and concluding. The results showed that Banjar Ulama contributed to the development of Islamic education in Samarinda City. The contribution was 1) establishing various types of Majelis Ta’lim in various cities of Samarinda; 2) functioning the mosque as a community education centre (congregation); 3) establishing formal education in madrasah and Islamic universities; 4) founding the first Islamic boarding school in Samarinda; 5) writing books as a reference in providing material in Majelis Ta’lim and the general public. Therefore, the results of this research were the evidence that the Banjar Ulama contributed in real terms to the development of education in Samarinda City.Abstrak:Samarinda merupakan kota multi etnis dan terdapat berbagai Ulama urban di Samarinda seperti Ulama Jawa, Banjar, Bugis, Madura.  Ulama urban mempunyai kontribusi yang signifikan dalam pengembangan Islam. Penelitian ini secara khusus mengkaji kontribusi Ulama Banjar dalam pengembangan Pendidikan Islam. Tujuan penulisan artikel ini adalah untuk mengetahui kontribusi Ulama Banjar dalam Pendidikan Islam di Kota Samarinda. Jenis penelitian ini adalah penelitian kualitatif dengan pendekatan historis-fenomenologis. Sumber data digali dari para tokoh Banjar, Paguyuban Banjar, dan Ulama keturanan Banjar. Metode penggalian data yaitu wawancara mendalam dan dokumentasi. Analisis data menggunakan analisis kualitatif yaitu reduksi data, penyajian dan penarikan kesmpulan. Hasil penelitian menunjukkan bahwa Ulama Banjar berkontribusi pada pengembangan pendidikan Islam di Kota Samarinda. Bentuk kontribusinya yaitu 1) mendirikan berbagai jenis mejelis Ta’lim diberbagai kota Samarinda; 2) memfungsikan masjid sebagai pusat pendidikan masyarakat (jamaah); 3) mendirikan Pendidikan formal berupa madrasah dan perguruan tinggi Islam; 4) mendirikan pesantren pertama di Samarinda; 5) menulis kitab sebagai referensi dalam memberikan materi dalam Majelis Ta’limmaupun masyarakat umum. Dengan hasi penelitian tersebut membuktikan bahwa Ulama Banjar berkontribusi secara riil pada pengembangan Pendidikan di Kota Samarinda.
HOMESCHOOLING: AN ALTERNATIVE TO NEW NORMAL ADAPTATION OF LEARNING
Authors: Damayanti Eka , Dewi Eva Meizara Puspita , Jalal Novita Maulidya , Rasyid Nurfajriyanti , Haeba Nurhaerani
Published: January 2021

Abstract:This research aims at finding out the public perception about the homeschooling which is chosen as an alternative in adaptation to the new normal learning. This research took forty-eight participants who are dominated by educators and magister or profession. Questionnaire as the instrument on this research was shared via google form. The collected data were analyzed by using descriptive statistics. The findings show that the participants think about the theme "Homeschooling: An Alternative to New Normal Adaptation of Learning" in workshop activities suitable with the conditions of the covid-19 pandemic and fulfill the participants’ needs. The previous studies show that many things should be considered by looking at the advantages and risks of applying homeschooling, which means that other alternatives such as pleasant activities can be applied during the new normal.Abstrak:Penelitian ini bertujuan untuk mengetahui persepsi masyarakat tentang homeschooling yang dipilih sebagai alternatif dalam adaptasi terhadap pembelajaran normal baru. Penelitian ini mengambil empat puluh delapan partisipan yang didominasi oleh tenaga pendidik dan magister atau profesi. Angket sebagai instrumen dalam penelitian ini dibagikan melalui formulir google. Data yang terkumpul dianalisis dengan menggunakan statistik deskriptif. Temuan menunjukkan bahwa peserta memikirkan tema "Homeschooling: Sebuah Alternatif Pembelajaran Adaptasi Normal Baru" dalam kegiatan lokakarya yang sesuai dengan kondisi pandemi Covid-19 dan memenuhi kebutuhan peserta. Studi sebelumnya menunjukkan bahwa banyak hal yang harus diperhatikan dengan melihat keuntungan dan risiko penerapan homeschooling, yang artinya alternatif lain seperti aktivitas menyenangkan dapat diterapkan pada saat baru normal.
KEKUATAN HUKUM PEMBUKTIAN AKTA NOTARIS AKIBAT PENYALAHGUNAAN KEADAAN
Authors: Saffanah Annisa Bella , Rizkianti Wardani
Published: January 2021

Notaries are often placed as defendants or co-defendants in civil lawsuits against the law regarding deeds that contain elements of undue influence. This journal writing focuses on the legal consequences of the state undue influence element against the Notary's authentic deed and the Notary's responsibility in making authentic deeds that contain elements of undue influence. The research method used in writing this journal is juridical normative through a statutory approach, a case approach, and a conceptual approach. The result of this research is that the legal consequences of a Notary deed that contain elements of undue influence can be canceled, degraded into deeds under the hands, can be canceled by agreement of the parties without court process, and can be canceled by the court based on the principle of legitimate presumption. As for the notary's responsibility for deeds that contain elements of abuse of circumstances are civil and administrative.
Covid-19 sürecinde tüketicilerin otel seçimini etkileyen faktörler
Authors: DEMİR Mahmut , DEMİR Şirvan Şen , ERGEN Fatma Doğanay , DALGIÇ Ali
Published: January 2021

Covid-19’un küresel ölçekte turizm sektörünü etkileyerek özellikle otel endüstrisi üzerinde ekonomik kayıplara sebep olduğu görülmektedir. Pandemi sürecinde tüketicilerin otel seçimlerini etkileyen faktörlerin bilinmesi otellerin uygulamalarını bu doğrultuda yeniden gözden geçirmelerine böylece söz konusu kayıpların giderilmesine katkı sağlayabilecektir. Bu kapsamda araştırma ile pandemi sürecinde tüketicilerin tatil satınalma davranışını etkileyen faktörlerin konaklama tesisi ve hizmetlerine yönelik tedbirler çerçevesinde değerlendirilmesi amaçlanmıştır. Araştırma kapsamında anket tekniğinden faydalanılmış olup araştırma 791 yerli turist ile gerçekleştirilmiştir. Pandemi sürecinde tüketicilerin tatil satınalma kararı üzerinde etkisine yönelik oluşturulan 5 hipotezden 4’ü desteklenmiş 1’i reddedilmiştir. Covid-19’a yönelik, tesisin Covid-19 tedbirleri, tesisin özellikleri, tesisin insan yoğunluğu ve tesisin hizmet uygulaması tüketicilerin tatil satınalma sürecinde otel seçim kararını etkilerken hizmet tercihlerinin bir etkisi olmadığı görülmektedir. Araştırmada pandemi koşulları dikkate alınarak tüketicilerin tatillerine ilişkin konaklama tesisi ve çevresine yönelik tedbirler önemli hale gelmektedir.
The Future Perception Gifted Individuals and Society about Gifted Individuals
Authors: Büyük Betül , Çelik Eyüp
Published: January 2021

This study examined the future perception of gifted individuals and society about gifted individuals. The study was carried out with a phenomenological approach, one of the qualitative research methods. The sample of this study was gathered from gifted students and adults in İstanbul and Kocaeli. The result of the research exhibits that gifted individuals were perceived as researcher-type people by both themselves and adults. Also, there is a need to improve gifted students’ educational process and reveal their potential skills. In addition, although people generally have a positive perspective on the future of gifted young people, it is frequently emphasized that the conditions they live in are worrisome.
Therapy with RAS inhibitors during the COVID-19 pandemic
Authors: Spaccarotella Carmen , Mazzitelli Maria , Migliarino Serena , Curcio Antonio , De Rosa Salvatore , Torti Carlo , Indolfi Ciro
Published: January 2021

Coronavirus disease 2019 (COVID-19) is caused by the novel coronavirus first identified in Wuhan, China. The global number of confirmed cases of COVID-19 has surpassed 28,285,700 with mortality that appears higher than for seasonal influenza. About 20% of COVID-19 patients have experienced cardiac involvement and myocardial infarction in patients infected with SARS-CoV-2 had a worse prognosis. Furthermore, the widespread use of antiviral drugs can be linked to a worsening of heart function. Arrhythmias and hypertension have also been reported in patients with Covid-19. On the other hand, previous cardiac diseases are present in 30% of patients infected with SARS-CoV-2. There is uncertainty in the use of ace inhibitors and angiotensin II (Ang II) antagonists in the COVID-19 era.

The mechanism of action of SARS-CoV-2 has been elucidated. It has been demonstrated that angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the new coronavirus SARS-CoV-2 and it is required for host cell entry and subsequent viral replication. The effect of the SARS-CoV-2 infection is the downregulation of ACE2 that may contribute to the severity of lung pathologies as well as the cardiac function.

ACE2, a homolog of ACE, is a monocarboxypeptidase that converts Ang II into angiotensin 1–7 (Ang 1–7) that with its vasodilatory, antifibrotic, antihypertrophic effects counterbalances the negative effects of Ang II. On the other hand, angiotensin-converting enzyme inhibitors (ACEi) and AT1R blockers have been shown to upregulate the expression of ACE2. Based on the mechanism of action of SARS-CoV-2, the use of renin angiotensin system (RAS) inhibitors was questioned although all scientific societies did not recommend discontinuation when clinically recommended. The BRACE CORONA, a phase 4, randomized study tested two strategies: temporarily stopping the ACE inhibitor/angiotensin receptor blockers (ARB) for 30 days versus continuing ACE inhibitors/ARBs in patients who were taking these medications chronically and were hospitalized with a confirmed diagnosis of COVID-19 was also discussed.

Therefore, the goal of this review is to summarize recent laboratory and clinical investigations concerning the use of ACEi and ARBs during the COVID-19 pandemic. The available data, based also on a randomized trial, suggest that ACEIs or ARBs, when clinically indicated, should be regularly used in the COVID-19 era.
Right ventricular endomyocardial biopsy in patients with cardiac magnetic resonance showing left ventricular myocarditis
Authors: Peretto Giovanni , Cappelletti Alberto M. , Spoladore Roberto , Slavich Massimo , Rizzo Stefania , Palmisano Anna , Esposito Antonio , De Cobelli Francesco , Margonato Alberto , Basso Cristina , Della Bella Paolo , Sala Simone
Published: January 2021

Aims

The aim of this study was to evaluate the sensitivity of right ventricular endomyocardial biopsy (EMB) in myocarditis patients with cardiac magnetic resonance (CMR) and electroanatomical mapping (EAM) showing left ventricular abnormalities.

Methods

We performed right ventricular EMB in 144 consecutive patients (66% men, age 43 ± 15 years) with acute symptoms and CMR-proved diagnosis of left ventricular myocarditis. Right ventricular EMB sensitivity has been evaluated in patients with different localization and extension of abnormal substrate at both CMR and -- when performed -- EAM. Abnormal substrate was defined, respectively, by late gadolinium enhancement (LGE) and low-voltage areas (LVAs).

Results

Globally, right ventricular EMB sensitivity was 87.5%. EMB-negative cases had significantly smaller fragment sizes (cumulative area 2.8 ± 1.7 vs. 3.8 ± 1.8 mm2, P = 0.023), and lower LGE surface extension (24.7 ± 14.2 vs. 38.5 ± 20.2%, P = 0.006) and transmurality (32.0 ± 26.1 vs. 49.3 ± 22.6, P = 0.003). Right ventricular EMB sensitivity in patients with LGE involving both right ventricular and interventricular septum (IVS), isolated right ventricular or IVS, and remote left ventricular areas (n = 10, 49 and 67 cases) was 83.3, 84.4 and 90.5%, respectively (P = 0.522). Overall, 34 patients (23.6%) underwent EAM. On the basis of EAM, right ventricular EMB sensitivity was 85.3%: in detail, it was 50.0, 88.2 and 86.7% in patients with both right ventricular and IVS, isolated right ventricular/IVS and distant left ventricular involvement (n = 2, 17 and 15, respectively, P > 0.05). Sample size area was the only factor associated with right ventricular EMB sensitivity (hazard ratio = 1.6/mm2, 95% confidence interval 1.1–2.4, P = 0.013).

Conclusion

Right ventricular EMB is still an accurate technique to confirm diagnosis in patients with CMR-proved left ventricular myocarditis. In particular, provided there is an adequate sample size, its sensitivity is comparable among patients with heterogeneous LGE or LVA localization.
Echoes of architectural modernism in J.G. Ballard’sHigh-Rise
Authors: Topolovská Tereza
Published: January 2021

This article pursues the elements of architectural Modernism in James Graham Ballard’s 1975 novel High-Rise (1975). The enormous tower block represents a triumph of technological and constructional progress envisioned by the pioneers of modernist architecture. However, Ballard’s vision of social development within it is regressive and violent. In order to decipher the nature of the role, or lack thereof, of the tower block in the reformulation of its own social fabric, the paper studies the ways in which the narrative presents aspects analogous to the key elements of architectural modernism. Particular attention is paid to the narrative’s reflections of radical and often contradictory visions of key figures of theoretical roots of modernism, such as Le Corbusier and Karel Teige. Their ambiguous stance on the core of modernism not only determines the outcome of the social experiment performed by Ballard in High-Rise, but can also be seen as deforming the building practice until today.
Tim O’Brien’s representation of the subjugated other’s voice against war in The Things They Carried
Authors: Aqeeli Ammar A.
Published: January 2021

Tim O’Brien’s Vietnam-based The Things They Carried has been criticized for exclusively depicting the painful and traumatic experiences of the American soldiers in the war zone. Despite the limited number of Vietnamese characters in the novel, and despite their relegation to the role of powerless and voiceless onlookers, their presence shows the degree of the power imbalance between Vietnam and America. This article demonstrates how O’Brien infused sentiments in his stories to emphasize his opposition to the war and his concern for the dignity of the Vietnamese people. O’Brien asserts that the main purpose of the United States’s invasion was to make Vietnam a learnable and controllable place. Through his critique of the United States’s imperial ambitions in Vietnam, O’Brien provides a representative voice for the people of Vietnam to share their sufferings from an unjust war.
Reflections on happiness and a happy life
Authors: Jakubovská Viera , Waldnerová Jana
Published: January 2021

The main objective of the following text is to focus on and exemplify the basic axioms of theories of happiness that come from historical and philosophical tradition and are still, at least in some cases, relevant nowadays. As philosophers claim, the longing for happiness is a naturally human desire that has taken various forms in their thinking: happiness was connected with beatitude (Aristotle), with self-preservation (Spinoza), social helpfulness (Hume), living in the present moment without expostulations or false illusions (Comte-Sponville), and others. The desire for happiness means the main aim of a human life drives particular life goals and the values of individuals. Concepts of happiness have accrued in diachronic and synchronic cross-sections. The Aristotelian/Spinozan conception or Kantian, modern and postmodern traditions formed in a diachronic cross-section. Those that accrued in a synchronic cross-section segregated themselves on the basis of an individual’s spiritual and bodily aspect. Spiritual happiness (spiritual bliss, and inner equilibrium, ataraxis) was preferred by the eudaimonic (ευδαιμονία) tradition (Democritus, Socrates, Aristotle, Hellenism, French materialism and others); bodily pleasures were accentuated by the hedonistic traditions (Lipovetsky, Bauman, Keller). Some conceptions examined the problem of happiness through the optics of society and the individual, stressing general goodness and helpfulness (Plato, Aristotle, Kant); or personal goodness, pleasure and benefit – the contemporary hedonistic concepts (Lipovetsky, Maffesoli, Comte-Sponville) All these conceptions of happiness are united by the common desire of people to live happily; however, their means and ways to reach such a goal are different.
Trophoblast stem cells - methods of isolation, histological and cellular characteristic, and their possible applications in human and animal models
Authors: Sibiak Rafał , Jaworski Michał , Barrett Saoirse , Bryl Rut , Gutaj Paweł , Kulus Jakub , Bukowska Dorota , Petitte James , Crha Igor , Ventruba Pavel , Zakova Jana , Mozdziak Paul , Ješeta Michal , Wender-Ożegowska Ewa
Published: January 2021

The placenta is a part of feto-maternal unit that develops from the maternal decidua basalis and fetal-derived trophoblast cells. The regulation of its early development is extremely intricate, albeit the elusive trophoblast stem cells (TSCs) are thought to give rise to the fetal part of the placenta. TSCs may be isolated in both animal and human models. In detail, TSCs can be efficiently obtained from the early conceptus tissues – blastocysts or early placental tissue. The isolation of murine TSCs pave the way for analyses of human trophoblast cell lineages. Both human and animal stem cells retain similar characteristic properties – the ability for unrestricted self-renewal and differentiation into all trophoblast cell lines. Nevertheless, there are some essential differences across the various species which are especially pronounced when pertaining to their distinct optimal cell culture requirements. Moreover, there are several crucial discrepancies in the stemness marker gene transcription profiles between human and murine TSCs models. In vitro TSC models can be adapted to the elucidation of the pathophysiology of various reproductive complications. For instance, their properties may illustrate the conditions observed during the implantation or simulate the state of abnormal placentation. Observations gained from the experimental studies could potentially explain the cause of some cases of infertility, preeclampsia, and fetal growth abnormalities.

Running title: Update on the trophoblast stem cells
qPCR analysis of mesenchymal stem cell marker expression during the long-term culture of canine adipocyte derived stem cells
Authors: Bryl Rut , Dompe Claudia , Jankowski Maurycy , Stefańska Katarzyna , Narenji Afsaneh Golkar , Kulus Jakub , Kulus Magdalena , Wieczorkiewicz Maria , Wąsiatycz Grzegorz , Jaśkowski Jędrzej M. , Kaczmarek Mariusz , Petitte James N. , Mozdziak Paul , Antosik Paweł , Bukowska Dorota
Published: January 2021

Due to its availability and accessibility, adipose tissue has been the subject of various studies in many different medical fields and is believed to be a useful source of stem cells. The ability of ASCs to differentiate towards different cell lineages, with possibility of directing this differentiation, increases their possible clinical applications, and they have been widely employed in multiple therapies and treatment of different pathologies. However, a deeper understanding of the molecular mechanisms underlying the ASCs osteoblastic and chondrocyte differentiation may lead to novel applications treating a multitude of different bone-related diseases through techniques more likely meeting worldwide consensus. In this study, the RT-qPCR method was used to determine the changes in expression of ASC specific markers (CD105, CD73, CD14, CD34, CD90 and CD45) before and after long-term (14-day) in vitro cultures. To confirm the identity of the investigated cells, flow cytometry was used to evaluate the presence of positive (CD44, CD90) and negative (CD45, CD34) ASC markers. Overall, the results of the PCR analysis showed a significant change in expression of most of the marker genes, indicating significant changes in the cultured cells caused by their long-term culture, potentially altering their original stem-like characteristics.

Running title: ASC marker expression during long-term in vitro culture
Apoptosis-related genes expression in primary in vitro culture of human ovarian granulosa cells
Authors: Kocherova Ievgeniia , Stefańska Katarzyna , Bryl Rut , Perek Joanna , Pieńkowski Wojciech , Zakova Jana , Crha Igor , Ventruba Pavel , Mozdziak Paul , Ješeta Michal
Published: January 2021

Ovarian granulosa cells (GCs) play a crucial role in oocyte maturation, creating a favorable microenvironment around the oocyte. Therefore, enhanced apoptosis and GCs loss may negatively affect the intra-follicular milieu and compromise the oocyte quality, reducing pregnancy chances. Based on the RT-qPCR method, the present research revealed the differential expression of apoptosis-related genes (BCL2, BAX, p53, CASP9) during the seven days of primary in vitro culture of GCs isolated from patients undergoing in vitro fertilization (IVF) procedure. Individual gene expression changes may reflect the GCs survival and/or apoptotic status at different time points.

Running title: Apoptosis-related genes expression in granulosa cells in vitro
Study of the expression of genes associated with post-translational changes in histones in the internal thoracic artery and the saphenous vein grafts used in coronary artery bypass grafting procedure
Authors: Kałużna Sandra , Nawrocki Mariusz J. , Bryl Rut , Stefańska Katarzyna , Jemielity Marek , Mozdziak Paul , Nowicki Michał , Perek Bartłomiej
Published: January 2021

Coronary artery disease (CAD) is one of the leading causes of mortality in the world. The most advanced forms of CAD are usually treated by means of coronary artery bypass grafting (CABG). The selection of the appropriate vessels as aortocoronary conduits is of paramount importance. The internal thoracic artery (ITA) or the great saphenous vein (SV) are often harvested. Furthermore, epigenetic processes have been recently associated with atherosclerosis, hypertension, and heart failure, and post-translational histone processes may play a key role in understanding the genetic predisposition of vessels to vascular diseases.

In the experiment performed, the transcript levels of JHDM1D, PHF8, and HDAC 1-3 in SV and ITA used for CABG procedures with RT-qPCR were examined. Total RNA was isolated by the method of Chomczyński and Sachi. RNA samples were reverse transcribed into cDNA using a commercial kit. The determination of the level of the transcripts of the mentioned genes was performed using the Light Cycler® 96 Real-Time PCR kit. Our analyzes confirmed that the studied genes related to post-translational modifications of histones are expressed in SV and ITA. In the saphenous vein, the expression of each of the individual genes was higher. The most considerable difference in transcript levels was recorded for HDAC1 and the smallest difference in expression for HDAC2.

Our research suggests that more processes related to histone demethylation and acetylation occur in the saphenous vein, which may affect the selection of a vessel for CABG, but this research requires more research and additional analysis.

Running title: Histone regulating gene expression in common coronary artery bypass graft vessels
Between Rudimentary and Artistic: Decorated Starčevo-Criș Pots
Authors: Tudorie Anamaria
Published: January 2021

The article presents new information regarding the percentual distribution of Starčevo-Criș decorated pottery, using the information on the Early Neolithic discoveries from the sites of Miercurea Sibiului-Petriș (Sibiu County), Turdaș-Luncă (Hunedoara County), Săliștea (Alba County), Cristian I (Sibiu County) and Cristian III (Sibiu County). Excepting Miercurea Sibiului-Petriș and Cristian I sites for which, besides the information about the category, color, temper, surface treatment, firing and morphology of this pottery were published in different volumes or articles, also some data regarding the different percentages on types of ornaments were published. This time, the author discusses globally the total amount of decorated pottery, taking into consideration also the relative chronological framings for each of the sites
The Central Area of a“ Square” from the Time of Turdaș Culture Turdaș-Luncă. 2011 Campaign. Sector C The Architectural Horizon before the great Migration from Turdaș
Authors: Perianu Florentin
Published: January 2021

The preventive excavation from 2011, at Turdaș-Luncă, led to the discovery of over 2000 archaeological features. Among them is feature 959. Through this article we want to continue the series of publications related to the preventive excavation of 2011 and highlight certain aspects related to a possible organization of the communities that lived here.