bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical Efficacy of Pathyadi Kwath Arka & Katphala Churna Nasya in the Management of Ardhavabhedaka with special reference to Migraine - A pilot Study
Authors: Bolkuntwar Shital
Published: January 2022

Ardhavabhedaka  can be correlated with migraine having similar symptom as half-sided headache. It is mentioned as tridoshapradhana by Sushruta and vatakaphapradhana by Vagbhata. Pathyadi Kwath is a proven formulation for urdhwajatrugata disorders including Ardhavabheaka. In addition, importance of Nasya karma in shirogata vyadhi cann’t be ignored so here pradhamana nasya with kataphala churna mentioned in Yogaratnakara is selected to evaluate its efficacy. Aim & Objective: The present study aimed to evaluate the clinical efficacy of Pathyadi Kwath Arka & Katphala Churna Nasya in the management of Ardhavabhedaka with special reference to Migraine. Material and method: The fruit of haritaki, bibhitaki, Amalaki, stem bark of nimba, whole plant of bhunimba, rhizome of haridra and stem of guduchi were used for the preparation of Pathyadi Kwath and its extract (arka) was prepared using the same ingredients by the process of distillation. Course powder of Kataphala was prepared in grinder, then filtered from mesh size 500 micron (BS 30, ASTM 35) and smooth powder of Kataphala obtained. Botanists carried out authentication of drugs. The study conducted on 10 samples for the duration of 12 weeks. Pathyadi kwath given in the dose of 10 drops/ 10 ml of water and kataphala churna pradhaana nasya; morning and evening daily. Result: Statistically significant p value was noted i.e.(P<0.05), the null hypothesis is accepted, hence it is clear that all the parameters show a significant difference in the observations (before treatment and after treatment). Conclusion: Pathyadi Kwath Arka & Katphala Churna Nasya is effective in the management of Ardhavabhedak.
Antimicrobial effect of Siddha preparation Vazhai kizhangu neer and Amuri against common urinary pathogens
Authors: A Sherin Nisha , S Sivakkumar , R Meenakumari
Published: January 2022

Urinary tract infection (UTI) is an infection.It occurs in any part of the urinary tract mostly affects lower urinary tract which is common in women. Almost half of all women will experience UTI once during their lifetime. The elderly, patients with diabetes or multiple sclerosis, patients with acquired immunodeficiency syndrome/human immunodeficiency virus, patients with spinal cord injuries and/or catheters are at high risk for UTI. Resistance development, adverse reactions of antibiotics, and other problems lead to find out the alternative approaches like remedies from natural resources in controlling UTIs. This study is aimed to validate the anti-microbial effect of natural products VazhaiKizhangu Neer and Amuri obtained from plantain tree (Musa paradisiaca Linn.) which are used for UTI in siddha system. The both samples were subjected to antimicrobial activity by well diffusion method. The result shows that, the zone of inhibition (in mm) for VazhaiKizhangu Neer and Amuri against common urinary pathogens E.coli, Pseudomonas aeuriginosa, Proteus mirabilis and Klebsiella pneumoniae was 14, 15; 9, 11; 0, 12; 14,13 respectively. These results revealed that both samples are potentially effective in suppressing microbial growth of urinary pathogens. Comparatively, the Antimicrobial activity of Amuri was almost equal to VazhziKizhzngu Neer. This study may authenticate the usage of VazhaiKizhangu Neer and Amuri for the management of Urinary Tract Infections.
Efficacy of Nyagrodh Twak Lepa in Honey bee sting: In-vivo study
Authors: Malik Amrit , Goyal Chinky , S P Abhiram , N G Gramopadhye
Published: January 2022

Introduction- As Acharya Charaka has explained the local application of Kshirivruksha Twak to cure all types of keeta visha, hence Nyagrodh (Ficus benghalensis L.) Twak Lepa with water as base is selected as Trial drug on Apis Cerana Indica bee sting poisoning. Material and Methods- An in-vivo study on albino mice to know the efficacy of trial drug has been planned after animal ethical clearance. 18 albino mice were prorated into three groups with 6 animals in each group viz. Control group, Trial drug (Nyagrodh Twak Lepa Churna) group and Standard drug (Beclomethasone Dipropionate 0.025% w/w) group. 6 stings were given to each mice and 3 stings were removed after sting operation. All mice were observed for allergic reactions viz. erythema, scaling, fissures, oedema and mortality for a period of 7 days. Histo-pathological changes were also noted after completion of study. Statistical analysis was done using Paired t test. Results- Results revealed that Trial drug had worked more efficiently on Erythema and Oedema while Standard drug worked more efficiently on Scaling and Fissure. Histo-pathology showed that wound healed with Nyagrodh twak lepa and Standard drug have shown almost similar changes while wound in control group showed extensive areas of necrosis. Conclusion- Present study suggests that both Nyagrodh and Beclomethasone can be used in Honey bee sting poisoning but as Nyagrodh being a religious tree can be easily identified by a common man, it can be employed as preliminary treatment for the same before reaching hospital.
Assessment of the Effect of Raga Therapy & Nisha Amalaki Churna on Prehypertension - A clinical study
Authors: Sharma Sunil , Bansal Charu , Shukla Umesh , Trupti Jain
Published: January 2022

Background: Prehypertension is classified as elevated blood pressure above normal by American medical classification. JNC 7 suggested systolic between 120 to 139 mmHg or diastolic 80 to 89 mmHg should be consider as Pre-hypertension. Oxidative stress develops due to stress and anxiety is recognized as main risk factor for initiation of hypertension. The Nada Yoga (sound based yoga) practices has been reported to decreases stress and anxiety. Nisha Amalaki Churna the combination of Amalaki (Indian gooseberry) and Haridra (turmeric) powder also reported to effectively reduces oxidative stress. Aim - To assess the combined effect of Indian Classical Raga Ahirbhairav and Hindol along with Nisha Amalaki Churna on Prehypertension. Material and method- It was clinical study. Total 48 patients selected by purposive sample technique and then divided into 2 groups (n = 24 each) randomly. Assessment was done by criteria of pre hypertension given by JNC 7. Result - In present study group A (Raga Ahirbhairav, Raga Hindol and Nisha Amalki Churna) patients the mean score of Systolic B.P. had decreased from 135.50 to 120.76 (Mean difference 14.74) with extremely significance (p <0.0001) compare to group B (only Nisha Amalki Churna orally) and mean score of Diastolic B.P. had decreased from 88.61 to 79.706 (Mean difference 8.904) with extremely significant (p <0.0001) compare to group B. Relief in mild headache 31.94% (p<0.01), relief in Anxiety 52.67% (p<0.0001) and relief on stress was reported 34.56% (p<0.0001) in Group A were reported, compare to Group B. Conclusion- result of study indicating that Raga therapy with Nisha Amalaki Churna had potential in the management of pre hypertension.
Comparative chemical profiling of purified and unpurified Strychnos nux-vomica Linn seeds: An attempt to reduce toxic Brucine content
Authors: Meena Ajay Kumar , Venktaraman Poorna , P Panda , C Murali Krishna , Ganji Kusuma , Dwivedi Durgesh Kumar , N Srikanth
Published: January 2022

Vishamusthi (Strychnos nux-vomica Linn.), a medicinal plant described as Upavisha (semi-poisonous) group of Ayurvedic Pharmacopoeia of India. Vishamusthi has widely been used and being practiced in several illness namely nervous debility, paralysis, weakness of limbs, sexual weakness, dyspepsia and etc. Ayurveda practices strictly recommend the use of Vishamusthi in therapeutics only after proper shodhana (purificatory procedure) through specific medias such as Gomutra (cow’s urine), Godugdha (cow’s milk), Goghrita (cow’s ghee), and etc. Although various shodhana procedures are recommended in Ayurvedic treatise, but updated scientific researches regarding the shodhana methods are lacking. The present study was undertaken to investigate the physicochemical and phytochemical parameters, quantitative estimation of brucine using cutting edge research tools such as high-performance thin layer chromatography (HPTLC), liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS) analyses of Vishamusthi seeds before and after purification. The remarkable changes have been observed in different physicochemical parameters, HPTLC, HPLC, GC-MS and LC-MS chromatographic profiling before and after shodhana process of Vishamusthi seeds. Quantitative HPLC studies revealed that the process of shodhana resulted in depletion of toxic brucine (chief poisonous constituent of Vishamusthi seeds) reduced to 79.66% in chloroform extract and 64.54% in ethanol extract after shodhana process.
Pharmacological aspects & medicinal uses of Trigonella foenum-graecum: A Current Review
Authors: Singh Veer Inder , Sharma Rahul Kumar , Kumar Yogesh , Saqulain Sadique
Published: January 2022

Globally a large number of people are affected by acute and chronic diseases resulting in high morbidity and mortality rate. A huge amount of pharmaceutical drugs are being manufactured on a daily basis to combat these diseases. But due to their high cost and deleterious effects, it becomes critically important to state emphasis on finding an alternative way to manage these long term conditions. Medicinal herbs could provide a good source of dietary supplement combined with existing therapies. Many scientific studies have demonstrated that medicinal plants and herbs have the potential for the treatment of many serious infections and many disorders. Out of these herbs, Fenugreek is recognized as an oldest herb with great medicinal potential. Fenugreek harbors many essential macronutrients and micronutrients along with trace elements. Numerous chemical constituents present in fenugreek highlights a variety of pharmacological activity such as anti-glycemic activity, anti-oxidant capacity, anti-inflammatory effects, hypocholesterolemic activity and many more. This article explores the diverse active compounds and potential pharmacological applications of Trigonella foenum-graecum also known as fenugreek. It also focuses on the medicinal significance and health impact of taking fenugreek in our day to day nutrition.
Antibacterial and antioxidant activity of different extracts obtained from Withania somnifera (Ashwagandha)
Authors: W W Kubukgolla , A M H S Attanayake , J A A S Jayaweera
Published: January 2022

Ashwagandha (W. somnifera) is widely known as the queen of Indian Ayurveda. The objective of this study was to determine the antioxidant and antibacterial activity of the different parts of the Ashwagandha.  The antioxidant activity of different extracts from different parts of Ashwagandha was determined using DPPH free radical scavenging method. Ashwaghanda root inhabiting bacteria was isolated using pour-plate technique. The agar well method and filter paper method were followed to assess the antibacterial activity of the extracts. Ethanol-water extracts (1:1 v/v) gave higher yield of extractable matter than methanol extracts. The antioxidant activity of fresh root extract was significantly higher than other parts of the plant (stem and leaves) as well as the plant material bought from open market. The minimal inhibitory concentration (MIC) values of Ethanol-water extract against MRSA, Candida Sp. and Salmonella Sp. were >256 mg/L. The commensal bacteria (Bacilli Sp.) inhabiting Ashwagandha roots displayed mild antibacterial activity against pathogenic P. aeruginosa.

Keywords:  Ashwaghanda, commensal bacteria, Antibacterial activity, Antioxidant activity, Crude extracts
Thrombolytic effect of Siddha herbal formulation Sikkanjar Manapagu using in-Silico model
Authors: N R Panneerselvam , B Anbarasan , T Subathra
Published: January 2022

Background: Thromboembolic disorders are one of the important causes leading to death. In the Siddha system of medicine, many drugs have been mentioned in the literature and their thrombolytic potential needs to be scientifically evaluated. Aim: The study aims to perform the In Silico computational studies of Phytoconstituents of Siddha formulation Sikkanjar Manapagu (SM) to evaluate its thrombolytic potential. Methods: Autodock program was used for the molecular docking studies of the retrieved phytoconstituents such as Zingiberene, Gingerenone-A, 6 Gingerol of Zingiber officinale, Menthol, Luteolin, Citronellol of Mentha arvensis, Eugenol, Limonene, Myrcene, and Linalool of Citrus aurantium against target protein Human Plasminogen Activation Loop Peptide - PDB 4DCB. Results: A total of ten compounds were screened, of these Zingiberene, Menthol, Citronellol, Eugenol, Limonene, Myrcene, and Linalool showed high binding against active amino acid residue 195. Conclusion: Based on further experiments and clinical trials, the formulation Sikkanjar Manapagu could be proved to be effective in thrombolytic treatment.
Go Ark; an ameliorative bio-product (in vitro) on Phenyl induced cytotoxicity
Authors: Gautam Daya Shankar , Mishra Saraswati , Marskole Prahlad , Tiwari Nisha , Kumari Anjali , Dwivedi Sakshi , Naz Kahkashan
Published: January 2022

Phenyl (PHY) is one of the chemicals which are used as a disinfectant in the world due to its toxic potential. Cleaning workers are directly exposed to it in institutes, hospitals and houses. Cow urine/Go Ark (GA) has been proved as a bioenhancer in many studies. The present study dealt with the in vitro analysis of PHY induced cytotoxicity (CT) on human peripheral blood lymphocytes and ameliorative potential of Distillate cow urine/Go Ark (DGA) and Fresh Go Ark (FGA) as GA is believed to be an elixir in Ayurved. MTT assay was used to study CT and Cell viability % on Human peripheral blood lymphocytes (HPBL) in vitro. CT of PHY was found to be higher than that of DGA and FGA treated groups. This showed that when PHY induced cells were treated with DGA and FGA, they showed increase in the cell viability %. It was also found that FGA had more potential for enhancing cell viability % of HPBL than that of DGA. We suggest that GA can be used as an ameliorative agent on PHY induced CT. It can be explored by in vivo experiments further for its detoxification properties. Now a day, PHY is used in combination with GA for cleaning purposes as “Gonyl”, it may be safe for cleaning workers to use GA based disinfectants to diminish the CT induced due to PHY exposure at the time of cleaning.
An obesrvational study to compare bala in Adana and visarga kaala with respect to physiological parameters
Authors: K Viswambharan Bindu , M Abhilash , Yohannan Anny
Published: January 2022

Introduction - Ayurveda gives utmost importance to the maintenance of positive health. Health and longevity in turn depends on bala or inherent strength of the individual. Bala is different in different seasons. Bala is examined as the capacity to do exercise, which is indicative of physical power of an individual. If the reflection of variation of bala on the basis of hematological parameters is identified, then it will provide many possibilities to modify the diet and lifestyle of healthy individuals in order to maintain health in all seasons. This work is a humble effort to analyze the seasonal variations in bala with respect to physiological objective parameters in the settings of Govt. Ayurveda medical college, Kannur, Kerala, India. Methods - In this study 30 healthy individuals between the age group of 20-30 were selected having similar vyayamasakthi- ie, based on the time taken to attain ardhasakthi lakshanas in treadmill test. First assessment was done in adanakaala. Their basic details, dasavidha pareeksha were taken before treadmill test. After 3 days of treadmill test, blood investigations were analyzed. The same procedure was done in visarga kaala also.Results - On the basis of analysis, the bala assessed by vyayamasakthi in visarga kaala was increased than adana kaala. Hemoglobin and HDL cholesterol were increased and serum calcium was decreased in visarga kaala. Considering vital parameters, increase in pulse rate, heart rate, systolic and diastolic BP was noticed in visarga kaala; all within physiological limits. Discussion – Bala was decreased in adana kaala due to the intensity of sunrays and intense dry wind. It causes decreased time to attain the ardhasakthi lakshana. Sweat occurs early. The bala was higher in visarga kaala compared to adaana kaala.
Modification of Kakubhadi Churna into malahara and its physicochemical analysis
Authors: Semwal Neha , D Rakshitha , K Govinda Sharma
Published: January 2022

Samskara is the process of modification of Guna of a given substance which is responsible for conversion of a raw material into medicine. These Samskara are responsible for the change in quality and property of any medicine. Primary preparations of Bhaisajya Kalpana known as Panchavidha kashaya Kalpana are modified into secondary dosage forms like Vati, Avaleha, Malahara, Sneha kalpana etc in order to achieve better shelf life, easy administration and palatability. Churna kalpana is an Upkalapana of Kalka kalpana, it is mentioned to be used in many disease conditions. One among these is Kakubhadi churna, which is indicated to be sprinkled externally on Dushta Vrana. As this method of application is cumbersome and not patient friendly, an attempt has been made to modify Kakubhadi churna into Malahara. Malahara is similar to ointments and creams in modern pharmaceutics. When compared to Churna, it has as an extended shelf life and also drugs in the form of Malahara are easy to apply and store. Taking all this under consideration, present study was taken up to modify Kakubhadi churna into Malahara. Physico chemical analysis of prepared Churna and Malahara was also done to achieve preliminary standard.
Efficacy of Ayurvedic herbal gel in the management of Dandruff: A case study
Authors: Dharkar Nilima , Pawar Madhuri , Jibi Vargese , Wele Asmita
Published: January 2022

Dandruff (Darunak)is the common skin disease affecting the scalp area with the presence of itching, hair fall, dryness of scalp and dander. It is affecting the half of the adult population of either gender worldwide. Even though the prevalence is so high, its etiology being varied the treatment modalities are also different. Although dandruff is not among those disease to cause severe illness or morbidity, but it has a lot of social concern which reflects individual’s confidence and self-esteem. This paper aims to present clinical case study presentation with diagnosis using advance technique of Trochoscopy and the management of dandruff with the topical application of Dashemani Kandughna gel which showed excellent results.
Hypolipidemia activity testing protocol or Guizotia Abyssinica Cass. seed oil: An Experimental study report
Authors: B Bani Shashikala , V Mallya Suma , Sudhakara Bhat
Published: January 2022

Hyperlipidemia is characterized by increased level of cholesterol in the form of low-density lipoprotein (LDL), chylomicrons, VLDL. Guizotia abyssinica Cass (Ramtil) seeds are one among the sources for the edible oil, which are low in saturated fat, cultivated commonly in Northern part of Karnataka. Materials and Methods: Guizotia abyssinica Cass (Ramtil) seeds were collected authenticated seed oil extracted by Cold compression method. The experiment carried out in Wistar albino rats, inducing Hyperlipidemia by HFD, along with administration of test drugs (Guizotia abyssinica Cass. seed oil Single and double dose) and Standard Atorvastatin.  Results & Discussion: G. abyssinica Cass seed oil found to decrease total cholesterol and LDL. Even not showed significant increase in HDL. Protective action over the Liver, Kidney and heart through histopathological study exhibit its safety aspect. Conclusion: G. abyssinica Cass seed oil in HFD induced Hyperlipidemia found effective and safe.
Practices of Niruha Vasti in Low back pain from an Academic Hospital of Kerala - An observational study
Authors: P Shabna , P P Jigeesh , V R Subin
Published: January 2022

Introduction: Niruha Vasti plays a major role when compared to Anuvasana, because of its variety of drug combinations and utility in a wide range of clinical conditions. Many formulations of Vasti are, in practice which came from the clinical experiences of eminent physicians and from researches. There is a deficit of baseline data regarding the current practices of Niruha Vasti in LBP and the preparation of which may help to prioritize the topics for further research. Materials and Methods: The study design was prospective cross-sectional observational study and sample included all the patients admitted in VPSV Ayurveda College Hospital, Kottakkal during January-December 2018, presented with LBP and posted for Niruha Vasti. Study tool used was a Data collection form which was prepared from available literatures. Data was verified, analyzed and presented with the help of tables and charts. Statistical analysis was done by Microsoft office 2016 and IBM SPSS Statistics version 16. Observation and Results: Total 141 patients were observed and among them 474 Vasti done in 174 schedules and 16 different types of Vasti were used. Vaitarana Vasti, Madhutailika Vasti, Kshira Vasti, Ruksha Vasti, Erandamuladi Vasti and Grdhrasihara Vasti are the major Vasti prescribed in LBP patients. Conclusion: There are certain characteristic patterns in the practice of Niruha Vasti administered in cases of Low Back Pain.
Качество и безопасность продукции как фактор национальной безо-пасности России: вопросы правового обеспечения в условиях политики импортозамещения
Authors:   Юго-Западный государственный университет, г. Курск, Россия, Воронцова Е.В. , Воронцов А.Л. ,   Юго-Западный государственный университет, г. Курск, Россия
Published: January 2022

В монографии исследуются вопросы правового обеспечения качества и безопасности пищевой продукции с позиций значимости данной проблемы для обеспечения продовольственной и национальной безопасности российского государства. Указанные вопросы анализируются с учетом геополитических реалий современного мира и необходимости для России противостоять санкционному давлению. В работе подвергнуты изучению общетеоретические и практические проблемы обеспечения продовольственной безопасности, а также концептуальные подходы законодателя к их решению. Характеризуются организационно-правовые аспекты обеспечения национальной безопасности в продовольственной сфере в условиях глобализации пищевого рынка и политики импортозамещения. Особое внимание уделено вопросам правового обеспечения качества и безопасности продуктов питания в контексте реализации основных прав потребителей, в том числе конституционного права на охрану здоровья. Авторами выявляются недостатки действующего правого механизма обеспечения качества и безопасности пищевой продукции, а также проблемы, осложняющие формирование более эффективного механизма в данной области. Исследуются основные направления контрольно-надзорной деятельности государственных органов в сфере обеспечения качества и безопасности пищевой продукции. На основе проведенного исследования предлагаются рекомендации по совершенствованию организационно-правовых механизмов обеспечения качества и безопасности продуктов питания. Материалы, изложенные в монографии, предназначены для специалистов в сфере контрольно-надзорной деятельности по обеспечению качества и безопасности продовольствия; ученых, занимающихся данными вопросами; представителей государственных и общественных организаций по защите прав потребителей. Исследование выполнено при финансовой поддержке РФФИ в рамках научного проекта №19-011-00926.
Kesabaran Ibu Merawat Bayi Berat Lahir Rendah (BBLR)
Authors: Sukirno Rita Setyani Hadi
Published: January 2022

Bayi Berat Lahir Rendah adalah bayi yang lahir kurang dari 2500gram. Merawat bayi BBLR membutuhkan perhatian lebih dibanding dengan merawat bayi dengan berat lahir normal karena BBLR memiliki kerentanan lebih tinggi terinfeksi penyakit, gagal tumbuh organ dan resiko kematian dibanding bayi lahir dengan berat normal. Penelitian ini bertujuan untuk mengetahui gambaran kesabaran ibu dalam merawat bayi BBLR. Desain penelitian ini adalah penelitian kualitatif. Subjek dalam penelitian ini: lima ibu yang melahirkan dan merawat bayi BBLR. Hasil penelitian menunjukan bahwa kelima subjek mampu bersabar dalam merawat bayi mereka. Kesabaran mereka dilandasi adanya keyakinan pada Allah sehingga membuat semua subjek mampu dengan tabah, gigih dan bersikap tenang dalam merawat bayinya. Kesabaran ibu dalam merawat bayi BBLR ini dipengaruhi oleh beberapa faktor seperti: faktor individu, faktor bayi dan faktor lingkungan sosial. Abstract. Low Birth Weight (LBW) Babies are babies born weighing less than 2500gram. Caring for LBW babies requires more attention than caring for babies of normal birth weight because LBW babies have a greater susceptibility to disease, organ failure and have a higher mortality rate than babies born at normal weight. This study aims to determine the description of the patience of mothers in caring for LBW babies. The design of this research is qualitative research. The results showed that the five subjects were able to be patient in caring for their babies. Their patience is based on a belief in God that makes all subjects able to be steadfast, persistent and calm in caring for their baby. A mother's patience in caring for an LBW baby is influenced by several factors such as: individual factors, infant factors and social environmental factors.
Rhabdomyolysis as a rare complication of bariatric surgery
Authors: Usta Sertaç , Karabulut Koray
Published: January 2022

Rhabdomyolysis after bariatric surgery is a quite rare occurrence with low recognition. Due to the breakdown of striated muscle fibers, creatine kinase and myoglobin are released into systemic circulation with variable effects on renal filtering functions. Herein, it was aimed to present a patient who de- veloped rhabdomyolysis following revision bariatric surgery. This 34-year-old male patient was admitted for bariatric surgery. He had had a gastric band surgery approximately six years ago, with regain of weight starting one year after surgery gradually reaching the previous weight level. Consequently, the gastric band had been removed with open surgery three years ago. The patient had a body mass index of 69 kg/m2 as well as an incisional hernia due to previous surgery. Although initially laparoscopic sleeve gastrectomy was planned, a switch to open surgery was made due to the presence of diffuse intra-abdominal adhesions and giant incisional hernia precluding laparoscopic intervention. The total duration of surgery was 420 minutes. Postoperative laboratory work-up showed elevated blood creatine kinase (25837 U/L). Upon the failure of fluid replacement and diuretics, hemodialy- sis was initiated at postoperative day 1. Despite daily sessions of hemodialysis, acidosis did not improve, his general status worsened and the patient died on postoperative day 14. Rhabdomyolysis is a severe and potentially life-threatening complication of bariatric surgery. Its severity may vary from asymptomatic elevations of creatine kinase to death. Postoperative creatine kinase levels should be routinely checked in high-risk patients as a practical and inexpensive laboratory modality for early diagnosis.
Comparison of laparoscopic percutaneous internal ring suturing method and open inguinal hernia repair in children under 3 months of age
Authors: Ergün Ergun , Yağız Beytullah , Alper Kara Yusuf , Nur Abay Aslı , Balcı Özlem , Eryılmaz Sibel , Faruk Özgüner İsmet , Karaman Ayşe , Karaman İbrahim
Published: January 2022

Objective: Laparoscopic inguinal hernia repair in younger infants has not been completely accepted worldwide. The aim of this study was to evaluate the safety and feasiblity of laparoscopic percutaneous internal ring suturing method in children aged younger than 3 months and compare the recurrence and complication rates with open repair; which may still be mentioned as the gold standard procedure.

Material and Methods: A total of 387 children underwent inguinal hernia repair in the clinic between 2016 and 2019. One hundred and forty of them were under 3 months old and divided into two groups; children who underwent laparoscopic percutaneous internal ring suturing (Group 1) and open surgery (Group 2). Selection of the surgical method was regardless of weight, sex or any patient characteristics other than surgeon’s choice. Operation durations, complications and recurrences were compared between the two groups.

Results: A total of 140 patients underwent surgery due to inguinal hernia. Group 1 included 85 and Group 2 included 55 children. There were two recurrences in each group (p> 0.05). Operative durations were shorter in Group 1 for both; unilateral and bilateral repairs (< 0.0001). There were no intraoperative complications in any group. There was one major postoperative complication in Group 2: iatrogenic undescended testis, and none was observed in Group 1. In the laparoscopic group, 47% of the children who were diagnosed to have unilateral hernia were revealed to have bilateral inguinal hernias (n= 31).

Conclusion: Laparoscopic percutaneous internal ring suturing method seems favourable in terms of operative time. It also has the advantage of detecting contralateral patent processus vaginalis or asymptomatic contralateral inguinal hernia.
COVID-19 disease information management model to reduce the negative impact on the infodemics of the university community
Authors: Montañez Flor B. , Morán Alberto L. , Meza-Kubo Victoria
Published: January 2022

The COVID-19 disease has put official health institutions on alert. They are aware of the problem of infodemics and the negative impact it has on health emergencies, and of the need to disseminate objective, complete and useful information on COVID-19 disease to all types of audiences. These have been supported by the different existing media and information systems that allow them to manage the infodemics. For this reason, this research topic proposes to define a model to manage information on COVID-19 disease, through a screening process (selecting, verifying, validating and presenting information) to deliver information in customized formats for specific audiences and reduce the negative impact of infodemics.
Feel and touch: a haptic mobile game to assess tactile processing
Authors: Monarca Ivonne , Tentori Monica , Cibrian Franceli L.
Published: January 2022

Haptic interfaces have great potential for assessing the tactile processing of children with Autism Spectrum Disorder (ASD), an area that has been under-explored due to the lack of tools to assess it. Until now, haptic interfaces for children have mostly been used as a teaching or therapeutic tool, so there are still open questions about how they could be used to assess tactile processing of children with ASD. This article presents the design process that led to the development of Feel and Touch, a mobile game augmented with vibrotactile stimuli to assess tactile processing. Our feasibility evaluation, with 5 children from 3 to 6 years old, shows that children accept vibrations and are able to use the proposed vibrotactile patterns. However, it is still necessary to work on the instructions to make the game dynamic clearer and rewards to keep the attention of children. We close this article by discussing future work and conclusions.
UTERHAP: Immersive virtual reality simulator for postpartum uterine involution using haptic devices
Authors: Cortes Francisco , Vázquez Diego , Ricárdez Eusebio
Published: January 2022

This work describes a virtual simulator integrating haptic devices with tactile feedback. The simulator allows users to perform the practice for palpation of uterine involution, where the user immerses in a virtual reality that brings closer to a real practice, the objective of this virtual environment is to speed up the learning process, since it provides practical notions to nursing students before having contact with real patients, highlighting that this simulator does not seek to replace real practice but rather to be an auxiliary tool.
Digital Disease Tracker v1.X, a mobile application to monitor the health of Mexican schools
Authors: García Mariángel , Luna Jesús Enrique , Morales Dorian Jesús , Rivera Armando , Magallanes Yazmín
Published: January 2022

After the recent return to face-to-face classes in schools in Mexico, after they were suspended due to the COVID-19 pandemic, it became clear that it was necessary to control students' health better. For this reason, we proposed the design of the Digital Disease Tracker, a system that works on mobile devices applying the User-Centered Design approach. Our system aims to allow a more complete, clear, and updated record of the student community. With this registry, educational institutions can better know the status of their students and know the level of risk in that institution to take measures to reduce it. With the evaluation carried out, we observed that the application is useful, and it is also an easy-to-use tool, which allows most users to use it without problems. It is essential to use these types of registries to help control the spread of various diseases in Mexico.
Interactive technology to support therapeutic interventions for emotional regulation of people with intellectual disabilities
Authors: Hernández Lara Marisela , Martínez-García Ana I. , Caro Karina
Published: January 2022

People with intellectual disabilities might experience difficulties in recognizing emotions, problems in understanding the causes and consequences of emotions, and problems with self-control, inhibition, and emotional regulation. Emotional regulation represents a significant hallmark of cognitive development and an important achievement associated with social, behavioral, and academic competence; therefore, people with intellectual disabilities need to learn how to regulate their emotions appropriately. An approach to support the emotional regulation interventions of this population is interactive technology such as video games, interactive floors, and virtual reality.  The literature includes some works on the design, development, and evaluation of technology for emotional regulation for populations that share some characteristics with people with intellectual disabilities, such as ASD and ADHD; however, the design of this technology does not consider some characteristics of people with intellectual disabilities. In this research, we propose to develop a model based on a set of technologies to support therapeutic interventions of emotional regulation of people with intellectual disabilities.
Design of user-centered technologies to facilitate the mobilization of social media data
Authors: Alvarado Garcia Adriana
Published: January 2022

My research aims to address the challenges involved in using social media data within institutional contexts such as non-governmental organizations that focus on facing human rights crises through programmatic and legal interventions. The central question guiding my research is: How do we design human-centered technologies that facilitate the migration of social media data flows from online communities to legal and political contexts that support the defense of human rights and institutional change? To answer this question, I propose the design and development of a set of computational and qualitative tools that will allow organizations to make use of social media data as evidence to inform their work.
How to The Impact on Transformational Leadership Style and Job Motivation On Organizational Citizenship Behaviour (OCB) With Job Satisfaction as Mediating Variables at Outsourcing Company
Authors: Arijanto Agus
Published: January 2022

This study aims to analyze the effect of transformational leadership style and work motivation on employee organizational citizenship behavior (OCB) mediated by employee job satisfaction. The object of the research is employees of PT. Sumberdaya Dian Mandiri with a sample of 95 people. Methods of data collection using questionnaire data collection and library research. Data analysis method using Partial Least Square. The result of this study show that (1) transformational leadership has a positive but not significant effect on organizational citizenship behavior (OCB); (2) work motivation has a positive and significant effect on organizational citizenship behavior (OCB); (3) transformational leadership has a positive and significant effect on job satisfaction; (4) work motivation has a positive and significant effect on job satisfaction; (5) job satisfaction has a positive but not significant effect on organizational citizenship behavior (OCB); (6) job satisfaction in mediating transformational leadership on organizational citizenship behavior (OCB) has a positive but not significant effect, and (7) job satisfaction in mediating work motivation on organizational citizenship behavior (OCB) has a positive and significant effect.
REVISÃO DA LITERATURA SOBRE O TRATAMENTO FARMACOLÓGICO DOS TRANSTORNOS ALIMENTARES
Authors: Ferreira Jacqueline Gabriele Soares , Oliveira Chrislen Nascimento de , Chagas Jhéssyca Glaycianne Souza das , Quemel Gleicy Kelly China , Galucio Natasha Costa da Rocha , Moreira Danilo Reymão
Published: January 2022

Os distúrbios alimentares são doenças de caráter psicopatológico e quando não tratadas corretamente prejudicam o indivíduo afetando-o socialmente, mentalmente e biologicamente. Dentro desse contexto, o trabalho avaliou, com base na literatura, os fármacos utilizados no tratamento dos transtornos alimentares. A metodologia utilizada foi a revisão integrativa da literatura com apoio da análise documental de Bardin. Para a busca das literaturas foram utilizados descritores, contidos nos DECs: [Transtornos da compulsão alimentar/Binge-Eating Disorder], [Tratamento Farmacológico/Drug therapy], [Bulimia/bulimia] e [Anorexia/anorexia]. Para coleta de dados, foram utilizadas literaturas encontradas na base de dado MEDLINE, na biblioteca do SCIELO e em repositórios. Foram selecionadas 22 literaturas, sendo que 63,6% (14) são da biblioteca do SCIELO, 18,2% (4) da base de dados MEDLINE e 18,2% (4) de repositórios de Ensino Superior. Foi observado que o uso de medicamento é essencial quando a terapia não medicamentosa não surtir efeito, uso de fármacos a Fluoxetina, Imipramina e Sibutramina são as principais medicações para o tratamento. Além disso, o tratamento dos transtornos alimentares exige uma equipe multidisciplinar para auxiliar no processo, com isto, o profissional farmacêutico exerce uma função primordial que garante um diagnóstico favorável e um tratamento adequado. Portanto, medicamento  como o dimesilato de lisdexanfetamina, utilizado no tratamento de lúpus, entre outros fármacos para tratar outras doenças podem ser de suma importância para o tratamento dos transtornos alimentares, quando associados a outras terapias não farmacológica e do acompanhamento com profissionais especializados
DETERMINAÇÃO DO TEOR DE VITAMINA C EM COMPRIMIDOS EFERVESCENTES DE DIFERENTES MARCAS COMERCIAIS DISPONÍVEIS EM DROGARIAS DA CIDADE DE ALMENARA - MG
Authors: Esteves Thamires Brandão , Moraes Breno Silva e Castro , Gomes Fernando José Santana , Matos Roberta Pereira , Gama Ednilton Moreira
Published: January 2022

A vitamina C tem importantes funções bioquímicas no corpo humano, como redução do envelhecimento da pele, acúmulo de ferro na medula óssea que proporciona maior imunidade, entre outras. A ingestão insuficiente de vitamina C via alimentos exige suplementação alimentar com suplementos, que estão disponíveis comercialmente, disponíveis na forma de comprimidos convencionais, efervescentes e mastigáveis, pós, grânulos ou cápsulas. Assim, o objetivo deste trabalho foi determinar o teor de vitamina C de 3 amostras de medicamentos e comparar com o valor do fabricante especificado na embalagem. As três amostras foram analisadas utilizando-se o método balentina por titulação, através da reação de redução de oxidação do iodato de potássio com ácido ascórbico identificado pelo aparecimento da cor verde característica do complexo ácido iodo-ascórbico. As amostras foram analisadas em triplicado e com os resultados obtidos (95,0±4,5%), 98,0±3,0%) e 94±5,4%) das análises pode-se verificar que estão em conformidade com os valores estabelecidos pela legislação.
A ANÁLISE CRÍTICA DO MOMENTO CONSUMATIVO NOS DELITOS DE FURTO E ROUBO
Authors: Oliveira Tatiane Leal de
Published: January 2022

O tema tem como finalidade abordar a respeito da diferença do momento em que se consuma os delitos de roubo e furto e, para isso, será realizada a conceituação, de forma clara e suscinta, cada delito e suas principais semelhanças e divergências. Nesse sentido, a determinação do momento consumativo do crime de furto consiste em um assunto bastante polêmico no âmbito doutrinário e na jurisprudência. Por esse motivo, diversas teorias surgiram com o intuito de estabelecer o momento exato da consumação do delito. Com base nisso, este trabalho utilizará doutrinas com o objetivo de compreender se a consumação é necessária para haver a posse tranquila da coisa e, ainda, se é necessário o emprego de violência ou grave ameaça à pessoa em casos de roubo e, por sim, se o agente, para consumar o delito, precisa retirar o bem material da posse da vítima e passar para a sua posse.
ESTUDO DA PRESUNÇÃO DE INOCÊNCIA - CONDENAÇÃO EM SEGUNDA INSTÂNCIA E A INFLUÊNCIA MIDIÁTICA
Authors: Oliveira Tatiane Leal de
Published: January 2022

O presente artigo tem como objetivo discutir o cumprimento da pena a partir da condenação em segunda instância, o conceito de presunção de inocência, mesmo que ainda caiba recurso, analisar casos existentes e as possíveis consequências dessa execução e compreender o entendimento do Supremo Tribunal Federal, do ministro da justiça e do atual presidente da república, acerca do tema, bem como a mídia e a opinião pública podem influenciar nos casos de grande comoção. O tema começou a ser debatido em 2009, pelo Supremo Tribunal Federal, que já entendia que a presunção de inocência não impediria execução da pena determinada em segunda instância. Muito se debate sobre o assunto, há opositores que questionam sua constitucionalidade, no que tange aos princípios discorridos na Carta Magna, em seu artigo quinto. Mas atualmente, a maioria dos ministros são a favor, ao destaque o da justiça e o atual Chefe de Governo. O trabalho foi realizado por meio da pesquisa bibliográfica através de livros, artigos, leis, sites. Após esse estudo, foi possível concluir o entendimento de que a partir da condenação em segunda instância esgota-se a presunção de inocência e culpabilidade do réu, por não se discutir fatos e provas, e também, que não há uma doutrina majoritária a cerca dessa nova tipologia de condenação e demonstra como a mídia exerce influência sobre os casos.
Cloning and Expression Analysis of bZIP Transcription Factor from Finger Millet (Eleusine coracana L.) Under Abiotic Stress Conditions
Authors: Lolita C Jenifer
Published: January 2022

Basic leucine zipper (bZIP) transcription factors comprise one of the largest gene families in plants. They play a key role in almost every aspect of plant growth and development and also in biotic and abiotic stress tolerance. In this study, we were attempted to study characterization of bZIP, a transcription factor from a climate smart cereal finger millet (Eleusine coracana L.). Seeds of Eleusine coracana (finger millet) was purchase from local market and were grown under field conditions drought and salt stress conditions. In this study, EcbZIP gene was isolated from finger millet, cloned into DH5α cells, screened by using colony PCR and expression analysis in response to two abiotic stresses was carried out by using qRT PCR. EcbZIP coding DNA sequence and protein sequence were retrieved from NCBI Nucleotide Database and Genpept of Accession number KP033192.1 and AJP67539.1 and validated by using SMART (simple modular architecture tool) Domain Tool. Cloning and expression studies were carried out using standardized molecular biology protocol. Results depicted that EcbZIP transcription factor showed significant upregulation under both salt and drought stress conditions, indicating that it plays an important role in tolerance towards these stresses. In conclusion, expression analysis of bZIP gene from finger millet seed cultivar ML-365 showed 5-fold upregulation to salt stress to drought stress and 8-fold upregulation to salt stress. Hence, it can serve as a candidate gene for improving abiotic stress tolerance and can be helpful in enhancing the crop productivity under stress conditions.
Netflix Bigdata Analytics- The Emergence of Data Driven Recommendation
Authors: Maddodi Srivatsa , K. Krishna Prasad
Published: January 2022

Netflix is one of the largest online streaming media providers. It began its operations in1997.Founded by two tech entrepreneur Reed Hastings and Marc Randolph. The Company’shead office is in Los Gatos, California. Netflix’s initially started selling DVDs or providethem on a rental basis. Over the period with growth of internet users and the decline of DVDsales and rental services, it changed its business model to video on demand. From 2012onwards, it started producing its original TV-series and movies. Netflix uses bigdata analyticsto understand its customers base better. By using these data, they provide better service orproduct to the customer. Netflix collects huge amounts of data from a vast variety ofsubscriber base. It collects data such as the location of a user; content watched by the user,user interests, the data searched by the user, and the time at which user watched. Based onthese parameters its algorithm gives a personalized recommendation based on the userinterest. Netflix has constantly focused on changing business needs they have moved theirbusiness model from DVD rental to video on demand and currently producing originalshows. In this paper we analyze various business strategies of Netflix. This paper alsoanalyzes how Netflix with the help of bigdata analytics focused on improving thesubscriber’s experience and how it helped to be more customer-centric and increased its userbase. Based on the SWOT and PESTLE analysis we have provided some suggestion that canbe incorporated by Netflix as business strategy.
El comercio en el centro histórico de Cartagena de Indias en pandemia: caso almacenes boutiques
Authors:   Universidad de Cartagena. Colombia, LONDOÑO Emperatriz , NAVAS Maria E. ,   Universidad de Cartagena. Colombia, DE LEON Natalia ,   Universidad de Cartagena. Colombia
Published: January 2022

En el presente trabajo se miran los cambios que han afectado la gestión de los empresarios de comercio en el subsector de las boutiques en el centro histórico de la ciudad de Cartagena, Colombia, durante la pandemia COVID-19 y en el marco de las necesarias medidas restrictivas adoptadas para mitigar la propagación del virus y la incursión en nuevas estrategias que apuntan a la recuperación y captura de nuevos segmentos del mercado.
La necesidad de establecer políticas públicas gubernamentales en Ecuador para garantizar el derecho a la salud de los adultos mayores
Authors:   Pontificia Universidad Católica. Ecuador, MONJE Emma A. , SAN LUCAS Maria F. ,   Pontificia Universidad Católica. Ecuador
Published: January 2022

El derecho a la salud está garantizado por el Estado ecuatoriano, sin embargo, las instituciones que se encuentran a cargo de responder por este, no garantizan la accesibilidad oportuna para los adultos mayores. Por ello, es importante analizar las políticas públicas dirigidas a este sector. La metodología a utilizar en la investigación es descriptiva. A través de métodos teóricos, se busca alcanzar resultados que determinen la atención prioritaria por parte de las instituciones estatales que ofrecen el servicio de salud.
Tres revistas: Tres visiones
Authors:   Universidad de Los Andes. Venezuela, FERRER-E Argelia
Published: January 2022

Se presentan tres entrevistas a los académicos que dirigen las revistas científicas de Comunicación Social en el ámbito iberoamericano Comunicar, Comunicación y Sociedad, y Disertaciones. Sus respuestas a un cuestionario sencillo permiten conocer los retos y pespectivas de esas publicaciones, así como las deficiencias y fortalezas de los artículos que reciben.