bluuebunny/crossref_metadata_2025 huggingface dataset:
REQUISITOS PARA A CONCESSÃO DO BENEFÍCIO POR INCAPACIDADE PERMANENTE NO REGIME GERAL DE PREVIDÊNCIA SOCIAL (RGPS)
Authors: Galvão Gabrielle Costa , Oliveira Tamar Ramos de
Published: June 2022

A Constituição Federal em seu art. 201 preconiza acerca da organização da previdência social, nos apresentando ao Regime Geral de Previdência Social e sus características. O Decreto 3.048 Regulamenta a Previdência Social, e a Lei 8.213/91, por sua vez, dispõe sobre os planos de benefícios do RGPS. Assim, apesar da existência de inúmeros benefícios previdenciários, o presente estudo tem como objeto de estudo a Aposentadoria por Incapacidade Permanente, popularmente conhecida como aposentadoria por invalidez. Para a concessão deste benefício, é necessário o preenchimento de alguns requisitos, dentre eles estão qualidade de segurado, a carência e a incapacidade, que deve ser comprovada através da realização de exame médico pericial, e é geralmente nesse momento de perícia que os segurados costumam ter problemas, haja vista a arbitrariedade no indeferimento do pedido. Deste modo, o que se pretende no presente estudo é analisar a Aposentadoria por Incapacidade Permanente e a subjetividade do profissional responsável pelo exame médico pericial, frente à padronização no procedimento. Para tanto, utilizou-se o método de pesquisa bibliográfica, baseada na legislação atualizada, doutrina e jurisprudência existente acerca do tema, tendo como método de abordagem o dedutivo através de um procedimento estruturalista que permitiu buscar informações acerca do problema, obtendo-se as conclusões adequadas.
Menerapkan K-Means Clustering untuk Segmentasi Gambar Database Berwarna
Authors: Sidik Aryo De Wibowo Muhammad , Himawan Kusumah Ilman , Suryana Anang , Edwinanto  , Artiyasa Marina , Pradiftha Junfithrana Anggy , Imamulhak Yufriana , Putra Yudha
Published: June 2022

Segmentasi gambar sangat penting dalam pendekatan analisis gambar untuk mempelajari gambar apa pun. Teknik pengelompokan K-means adalah algoritma yang banyak digunakan dalam sistem segmentasi citra. Karya ini memanfaatkan ruang warna L*a*b* dan pengelompokan K-means untuk menawarkan segmentasi gambar berbasis warna. Penelitian ini menunjukkan segmentasi gambar database berdasarkan karakteristik warna menggunakan teknik K-means clustering unsupervised yang diimplementasikan dengan coding MATLAB. Seluruh pekerjaan dipisahkan menjadi dua fase. Pertama, augmentasi pemisahan warna dari gambar warna database ditingkatkan melalui peregangan de-korelasi. Kemudian keenam area citra database tersebut dikelompokan menjadi tiga kelompok dengan menggunakan teknik K-means clustering. Dengan menggunakan ruang warna L*a*b* dan metode pengelompokan k-means dalam gambar basis data warna, kita hanya dapat menunjukkan wilayah tengah dari gambar apa pun. Kami dapat mengisolasi daerah yang terkontaminasi dalam gambar berwarna database medis dengan pendekatan ini dan mengobati penyakitnya dengan cepat. Kami dapat menggunakan berbagai pendekatan seperti Particle swarm Optimization (PSO) untuk hasil yang lebih baik.
Analyzing the Potential for Utilization of New Renewable Energy to Support the Electricity System in the Cianjur Regency Region
Authors: Sidik Aryo De Wibowo Muhammad , Akbar Zafar
Published: June 2022

Energy is one of the basic human needs to support activities whose numbers continue to increase along with population and economic growth. On the other hand, most of the energy used today comes from fossil-based energy which has non-renewable properties so its reserves will run out if used continuously. Indonesia in general and the Cianjur region of West Java Province, in particular, has a wide variety of potential for new and renewable energy spread over most of its territory, including solar energy, wind energy, bioenergy, marine energy, and geothermal. This study aims to map the potential of New Renewable Energy in the Cianjur area to support the government's target of achieving the national energy mix and encourage energy diversification in the electricity system. The results of the study indicate that there is a large potential for renewable energy from various types of energy in the Cianjur area which can be utilized in the conversion process into electrical energy.
Functional aspects of Pistia stratiotes, an invasive plant of Al Jawahir (Fez) wadi lentic habitats
Authors: Chadli Chaimae , Libiad Mohamed , Khabbach Abdelmajid , Bouslamti Rabia , Ennabili Abdeslam
Published: June 2022

Excessive growth of invasive alien aquatic plants threatens local ecosystems and has both ecological and economic impacts. This work highlights morphological and functional aspects of Pistia stratiotes L., first reported in Fez in 2012. The total photosynthetic surface of a Pistia plant is highly correlated (R2=0.72) to the product of the length and maximum width of the external leaf. The total biomass of Pistia was highly related (R2=0.71) to plant size and averaged 67.54±26.35 g dw.m-2. Its peak does not necessarily co-occur with flowering and/or high production of stolons. The total nitrogen and phosphorus mineralomasses correspond to 11.46±4.55 kg N.ha-1 and 0.83±0.33 kg P.ha-1. The biomass and mineralomasses of Pistia, estimated under these invasive conditions, ranks it among the least productive Moroccan wetland plants.
El estrés generado por los estudios durante la pandemia en función del sexo, la edad, el hábitat y el nivel de estudios en jóvenes españoles: Un modelo predictivo
Authors: Durán Díaz Rebeca M.
Published: June 2022

La pandemia por coronavirus ha generado un cambio en la forma de vida, las costumbres y la educación de muchas sociedades. El objetivo de este estudio es conocer el poder predictivo que tiene la edad, el sexo, el hábitat y el nivel de estudios de los jóvenes españoles de entre 15 y 29 años en el nivel de estrés generado por los estudios, dada la digitalización educativa forzada por la pandemia. A partir de una base de datos elaborada por el Centro Reina Sofía sobre Adolescencia y Juventud y la Fundación de Ayuda contra la Drogadicción (FAD), se ha desarrollado un análisis de regresión lineal múltiple, obteniendo un modelo predictivo en el que el sexo figura ser buen predictor del nivel de estrés académico. El resto de los hallazgos han sido contraintuitivos, dado que cabría pensar que las personas mayores sufren mayor estrés, igual que las de mayor nivel de estudios, y que el hábitat podría ser muy relevante. Para mayor enriquecimiento y fundamentación, se han contrastado los resultados con las investigaciones más relevantes y recientes en materia de educación.
Desigualdad educativa en medio de una pandemia: El papel inclusivo y exclusivo de los medios sociales según el profesorado
Authors: Papanikolopoulou Arco Laura Joana
Published: June 2022

En marzo de 2020 la emergencia sanitaria producida por COVID-19 obligó a las autoridades estatales y autonómicas a decretar el confinamiento. Como medida de protección, los centros educativos fueron obligados a continuar con la formación del alumnado a distancia, utilizando distintos medios tecnológicos que se convirtieron en su herramienta principal de trabajo. No obstante, el uso exclusivo de estos medios dificultó la continuidad formativa. El objetivo de este estudio es conocer las opiniones del profesorado de educación secundaria obligatoria sobre los efectos de la enseñanza digital en la inclusión y exclusión social del alumnado. La metodología empleada se basa en la recopilación de datos mediante un cuestionario de carácter autoadministrado que fue distribuido a los centros de educación secundaria en el País Vasco y la comunidad Foral de Navarra mediante correo electrónico. Los resultados muestran que una educación plenamente digital presenta ventajas y desventajas tanto para el alumnado como para el profesorado. El artículo concluye que los medios sociales podrían promover la inclusión social en entornos ideales, pero que no pueden lograrlo en las situaciones actuales.
Imagen educativa de la tecnología en la COVID-19. La mirada del alumnado de Magisterio con mención TIC
Authors: Suárez-Guerrero Cristóbal , Lloret-Catalá Carmen , Lizandra Jorge
Published: June 2022

Este artículo tiene como objetivo caracterizar la percepción educativa de la tecnología digital en la crisis de la COVID-19 de un colectivo singular: el alumnado de magisterio en la especialidad en Tecnologías de la Información y la Comunicación. Para ello se realizaron, en pleno confinamiento, cuarenta y tres entrevistas asíncronas a partir de una pregunta abierta a los y las estudiantes de la especialidad de TIC del Grado en Maestro/a en Educación Primaria de la Universitat de València. La visión educativa de la tecnología que tiene este grupo de alumnos y alumnas no es la clásica visión instrumental basada en soluciones tecnológicas para males educativos en pandemia. Es más bien una lectura analítica del problema educativo que evalúa el calado de la respuesta digital durante el COVID-19, y que identifica alternativas a la educación digital de emergencia además de hacer suya una visión integrada de la función docente anclada en la competencia digital como exigencia formativa.
Tecno-nacionalismo y nacionalismo digital en la cuarta revolución industrial
Authors: Gayozzo Piero
Published: June 2022

El fenómeno nacionalista ha jugado un rol importante en la historia contemporánea. Actualmente nos adentramos a la Cuarta Revolución Industrial, un proceso de cambios sociales y políticos impulsados por la inteligencia artificial, la conectividad 5G y otras herramientas tecnológicas de vanguardia. El presente trabajo explora la manifestación del nacionalismo en la Cuarta Revolución Industrial. Para ello, se abordarán los conceptos de tecno-nacionalismo y nacionalismo digital, su relación y sus diferencias. Luego se explicará cómo los medios digitales afectan el auge del tecno-nacionalismo y se ofrecerá una definición más amplia del concepto, el cual incluye las ideas de territorio digital, cultura digital e identidad digital. Finalmente, se concluye que el tecno-nacionalismo es una manifestación compleja del nacionalismo que incluye no solo la búsqueda de soberanía tecnológica de un país, sino que posee un componente ideológico fuertemente vinculado al uso político de las tecnologías de vanguardia.
LEADERSHIP AND DICTATORY IN CONTROL THE COUNTRY: FASCISM AND WAR
Authors: Yu. Batyr , I. Lopatchenko
Published: June 2022

The problem of leadership in the system of public administration is studied. The factors of formation and the role of leadership in public administration in the 21st century are substantiated. The main factors and stages of dictatorial leadership in the Russian Federation have been identified and Putin is the most dangerous and schizophrenic entity in the 21st century, which has started a bloody war not only with Ukraine but with the entire civilized world. In contrast, the President of Ukraine Volodymyr Zelensky is the most powerful, outstanding leader in the modern world. Its mission is to unite Ukraine and the world to defeat the bloody dictator, a terrorist country and save the democratic world.
THEORETICAL ASPECTS OF MECHANISMS OF FORMATION OF SUSTAINABLE DEVELOPMENT OF THE REGION
Authors: N. Leonenko
Published: June 2022

The article comprehensively examines the conceptualization of national interests in the field of international relations. The author through a comprehensive analysis of scientific and methodological literature determined that based on the conceptualization of mechanisms for the formation of sustainable development of regions, the mechanism for implementing sustainable development strategies at the regional level should be considered as a tool for direct impact on socio-economic system. Analysis of the socio-economic situation in specific regions, aimed at developing an active policy of sustainable development, showed that a special approach to solving the problem of sustainable development, related to the structure of the district's economy, its demographic, national and religious composition, natural conditions, state of use subsoil and their prospects. Such an analysis showed that in order to ensure sustainable socio-economic development of the region, it is necessary to adhere to a certain hierarchy of goals and priorities.
Emphasis is placed on the fact that among the many mechanisms for the formation of sustainable development, special attention is paid to such methods as organizational and technological, socio-economic; administrative. In particular, the organizational and technological method, first of all, involves the creation of a specialized, dedicated organizational structure, the area of responsibility of which is the creation, maintenance and operation of the entire structure of the mechanism. Performance of official duties is carried out by means of the modern software and hardware complex which separate aspects are used for the decision of the set tasks, within the limits of achievement of the purposes of sustainable development. It stated that the fact that all the problems of social and economic development of the region cannot be solved without financial support, bearing in mind the whole range of budget financing, monetary circulation, liquidity, and the functioning of the securities market, because for a market economy mobilization of financial resources and their effective use are gaining importance in the implementation of social and economic programs.
STATE POLICY OF UKRAINE'S INTEGRATION INTO THE INTERNATIONAL SAFTY AREA IN THE CONDITIONS
OF GLOBAL TRANSFORMATIONS
Authors: V. Kropyvnytskyi , Yu. Krykhtina , A. Treskov , S. Maistro
Published: June 2022

The article describes the peculiarities of the state policy of Ukraine's integration into the international security space in the conditions of global transformations. The degree of effectiveness of the state policy of Ukraine's integration into the international security space in the conditions of global transformations is determined. The problematic aspects and contradictions of the state policy of Ukraine's integration into the international security space in the conditions of global transformations are highlighted. The directions of transformation of the state policy of Ukraine 's integration into the international security space in the conditions of global transformations are determined.
OPPORTUNITIES AND CHALLENGES FOR DEVELOPMENT OF RURAL GREEN TOURISM IN UKRAINE: THE PUPLIC MANAGEMENT ASPECT
Authors: N. Hrabar , L. Hren , S. Karlyuk
Published: June 2022

The role of rural green tourism as one of the ways for agricultural production sustainable development is researched in this article; it is proved that rural tourism in Ukraine enhances development of villages’ infrastructure, enables popularizing the history, folklore, culture and traditions among the local citizens and on the global scale alike; it is also a cause for rural homesteads improvement and benefits the hosting families’ financial state. The following problem issues for rural tourism subjects are distinguished: organizational disjointedness, insufficient development of the basic and auxiliary infrastructure, not high enough service level, and lack in advertising and informing activity in promoting the relevant products and services. It is accentuated on regional offices for agriculture, local authorities and public organizations having great opportunities for green rural tourism development and influencing it significantly; micro-social and macro-social barriers are mentioned that impede this sector’s development. The importance of agri-tourist homesteads owners’ interest and initiative in forming and development of local and regional unions and significance of their support by local authorities and the regional and central power bodies, scientific and public organizations in facilitating the activation of green rural tourism development in Ukraine is proved.
PSYCHOLOGICAL FEATURES OF THE SUCCESS OF THE LEADER IN PUBLIC ADMINISTRATION
Authors: I. Lopatchenko
Published: June 2022

The general characteristics of the head of public administration has been justified. The main components of the psychology of success of the head of a modern public institution has been considered. Foreign experience in the psychology of success of the head of a modern state institution has been studied.
Psychological features of the success of the leader has been identified. The main recommendations on the main problems of success of a modern leader in public administration has been developed.
PECULIARITIES OF APPLICATION OF THE PROJECT APPROACH IN PUBLIC ADMINISTRATION
Authors: D. Tokarchuk
Published: June 2022

The article reveals the essence of the project approach as one of the most effective mechanisms for improving efficiency in public administration. The essence, features of projects and their application in the public sphere are determined. The development of the project approach in recent years in Ukraine is analyzed.
Fabrication and Evaluation of Cefpodoxime Proxetil Niosomes
Authors: Fouziya Bandagisa , Abdul Ahad Hindustan , Swamy Charan Dontha , Sri Vidya Jagarlamudi , Chandana Reddy Ummadi , Nandini Reddy Puli
Published: June 2022

The authors aimed to create and characterise Cefpodoxime Proxetil (CDP) niosomes with site-specific delivery in order to minimise disruptions in gastric disintegration and absorption and achieve the desired therapeutic response. CDP niosomes were created using an Ether injection process with a variety of CDP, cholesterol, and Sorbitans concentrations (Span 40, 60 and 80). Compatibility studies with the excipients used, vesicular shape, size, entrapment efficiency, drug content, and in-vitro drug release were all performed on the fabricated niosomes. The results revealed that the primed niosomes pass and satisfy all physicochemical characterizations performed. The study concludes that CDP can be formulated as niosomes by ether injection techniques for enhanced absorption of drug.
Assess Knowledge and Attitude regarding health effects of over usage of internet among GNM students
Authors: M J Shaiji , Verma Adarsh , Mandal Ashalata , Jetha Geeta , Rani Manisha , Kaur Payal , Husain Risalat , Swati Swati , Joshi Vidya
Published: June 2022

A descriptive study was conducted to assess the knowledge and attitude regarding health effects of over usage of internet among GNM students of selected nursing colleges in Udham Singh Nagar, district with a view to develop a information booklet. Methodology: Quantitative research approach was used for the study non experimental descriptive survey research design was selected. The data were collected from 60 students, who were selected by non-probability purposive sampling technique.. The tools used for the study was structured questionnaire to assess socio demographic data, structured questionnaire to assess the knowledge and attitude assessment scale to assess the attitude regarding health effects of over usage of internet. Results: The findings of the study revealed that knowledge level of student’s majority 50% had good knowledge, 41.66% had average and 8.33% had poor knowledge. The attitude of students regarding health effects of over usage of internet was positive. The correlation implied that there was a very week positive relationship between knowledge and attitude of students (r 0.02, p >0.05). The result showed that there was no significant association between knowledge regarding health effects of over usage of internet with any of the selected socio demographic variables.
Effectiveness of Video-assisted teaching on knowledge and skill regarding prevention of breast cancer among nuns
Authors: George Betcy
Published: June 2022

Cancer is a group of more than 200 diseases characterized by uncontrolled and unregulated growth of cells. Breast cancer is probably the most feared among women, due to its high incidence, and above all, to the psychological effects that affect their perception of sexuality and their self image. An early diagnosis is the best guarantee of success in the treatment of breast cancer and the woman gives a relevant contribution in the early detection when she systematically does the self-examination. The objectives of this study were to assess the effectiveness of video-assisted teaching programme on knowledge and skill regarding prevention of breast cancer among the nuns and to find the association between the pre-test knowledge level and pre-test skill with selected demographic variables. A quantitative one group pre-test post-test design (quasi experimental) was adopted for the study. The conceptual framework of this study was based on the Health Belief Model (HBM) presented by Rosenstoch’s (1974) and Becker and Maiman’s (1975). Thirty nuns were selected by non probability purposive sampling technique. Video-assisted teaching was administered to the samples after the pre-testing of both knowledge and skill. Data was collected by using demographic proforma, structured knowledge questionnaire and observational checklist. The data was analyzed using descriptive and inferential statistics. The data concerning the effectiveness of video-assisted teaching was established by analyzing the pre-test and post-test knowledge score and skill of the respondents. In order to find out the effectiveness of video-assisted teaching on prevention of breast cancer of experimental group, paired ‘t’ was computed. The computed ‘t’ value of knowledge score and skill (11.0 and 15.5) was greater than the table value (t29=2.05; p<0.05). This represented that video-assisted teaching was effective in improving the level of knowledge and skill of nuns on prevention of breast cancer. Chi-square test was used to test the significant association between pre-test knowledge scores and skill in performing BSE with selected demographic variables. The test revealed that there was no significant association between pre-test knowledge scores and selected demographic variables at 0.05 level of significance. On the other hand, it showed a significant association between the pre-test skill and the demographic variables namely, educational qualification and awareness of samples with relatives, friends or colleagues with breast cancer. The study concluded that the video-assisted teaching programme for nuns significantly improved their understanding and skill on prevention of breast cancer.
A Study on The Effectiveness of Structured Teaching Programme on Knowledge regarding Prevention of Hospital Acquired Infection among student nurses of selected colleges of Meerut
Authors: Raj M.A. Meera , Singh Harimohan
Published: June 2022

Introduction: Hospital acquired infections are most common in the developing countries like India. Improper handling and management of the biomedical or hospital waste is also an important cause of the health associated infections. Hospital acquired infections also referred to as health care associated infections (HAI), are infections acquired during the process of receiving health care that was not present during the time of admission. Adequate knowledge regarding use of techniques like standard safety precautions, universal precautions and aseptic techniques can reduce hospital acquired infections to a great extent. Materials and method: The design used for study was experimental research design. The study was conducted on a sample of 50 student nurses. Self structured questionnaire was used as a tool for data collection. Results: The study result reveals that 0(0%) student nurses had good knowledge regarding prevention of hospital acquired infection and 30(60%) student nurses had average knowledge before administering structured teaching program and 20(40%) had poor knowledge. Post test results revealed that 9(18%) student nurses had good knowledge score and 41(82%) had average knowledge score after administration of structured teaching program on prevention of hospital acquired infection. Association of different demographical variables with the level of knowledge before undergoing structured teaching program was assessed using x2 and it has been found that there is no significant association between the level of knowledge and socio-demographic variable. Conclusion: The findings of the study revealed that application of structured teaching program has increased the level of knowledge of student nurses to a great extent and there is no association between the level of knowledge regarding prevention o hospital acquired infection among the student nurses of selected colleges in Meerut to their socio demographic variables.
A Study to assess the Effectiveness of Billig’s Exercise in reducing Dysmenorrhoea among Adolescent Girls
Authors: V Priya. , Malarpriya Malarpriya
Published: June 2022

Statement of the Problem: A study to assess the effectiveness of Billig’s exercise in reducing dysmenorrhoea among adolescent girls at Alchemy school, saravanampatti, Coimbatore. Study objective: (a) To assess the pre test level of dysmenorrhoea among adolescent girls in the experimental and control group(b)To assess the post test level of dysmenorrhoea among adolescent girls in the experimental and control group (c)To assess the effectiveness of Billigs exercise on dysmenorrhoea among adolescent girls in the experimental group (d) To find out the association between post test level of dysmenorrhoea among adolescent girls with their selected demographic variables. Methodology: Experimental approach, a subtype of quantitative approach, the research design was quasi experimental design, non equivalent control group pre test and post test was used for the present study. The sample for the study consists of 60 adolescent girls with dysmenorrhoea, 30 in experimental group and 30 in control group, selected by purposive sampling techniques, a type of non probability sampling method. Numerical Pain Intensity Scale was used to assess the level of menstrual pain of adolescent girls is both group. Results: Inferential and descriptive statistical were used to analyze the data. The pre test value of menstrual pain in adolescent girls for experimental and control group was 5.2 and 4.63 respectively. The mean post test score was 1.8 and 4.33 for experimental and control group. The comparison was done between two group by performing the independent‘t’ test and the value was 5.57.Conclusion: The study shows that Billig’s exercise is effective to reduce menstrual pain among adolescent girls.
QUEM QUER A SUA MTV? CAMINHOS DE UMA NOVA EMISSORA NO BRASIL (1984-1990)
Authors: Oliveira Carlos Eduardo
Published: June 2022

O presente trabalho analisa as tentativas de entrada da MTV no Brasil durante a década de 1980, no contexto de transição democrática e a promulgação da Constituição Federal de 1988. A MTV Brasil inicia suas operações em 1990, através do acordo entre Grupo Abril e Viacom, sendo a primeira emissora segmentada no país, direcionada ao público jovem e transmitida em UHF. Sua particularidade repousa na transmissão em rede aberta e inserida no contexto de renovação e liberdade da sociedade brasileira, que estruturaram narrativas de abertura política, social e cultural, tendo como marco a promulgação da Constituição Federal de 1988. Assim, este artigo procura aproximar os motivos pelo qual as propostas de entrada da MTV não se efetivaram, nos acordos com TV Gazeta em 1985, e Rede Manchete em 1986, e o processo pós-ditatorial envolto por rupturas e permanências na construção da democracia. O acordo entre MTV e Grupo Abril foi possível por conta da efetivação da Carta Constitucional, que garantia o fim do aparato censório estatal, e a nova regulação das concessões de televisão. Utilizo como fonte os jornais Folha de São Paulo e Jornal do Brasil, com matérias que versaram essas questões. Para isso, diálogo com Renato Ortiz e Marcos Napolitano, na compreensão do processo de modernização cultural brasileira e os caminhos políticos nos anos 1980, e Reinhart Koselleck na análise dos futuros-passados que envolveram a MTV.
Design, Formulation and In Vitro Evaluation of Oxybutynin HCl Floating Matrix Tablets
Authors: Saleh N. Safiya , Vikas Swati , Panda Niranjan
Published: June 2022

The goal of this study was to prepare and test a hydrodynamically balanced floating matrix controlled Oxybutynin HCl drug delivery system. The muscarinic acetylcholine receptor subtypes M1, M2, and M3 are competitively antagonized by oxybutynin HCl. It is used to treat urinary and bladder problems. It has a 10-12 h elimination half-life. The effervescence produced by the combination of sodium bicarbonate with hydrochloric acid in the stomach causes the Oxybutynin HCl tablets to float in the stomach. Twelve alternative floating tablet formulations were made utilizing direct compression using hydrophilic polymers like HPMC K4M, K15M, and K100M and hydrophobic polymers such ethyl cellulose in various ratios. The produced formulation was characterized using FTIR and DSC analysis. In terms of general appearance, content consistency, hardness, friability, and buoyancy, the examination found that all formulations meet the specifications of official pharmacopoeias and/or standard reference. Formulation F11, which contained 25% HPMC K100M and 12.5% ethyl cellulose, had the best in vitro drug release up to 99% after 12 hours. The formulations with more than 12.5% NaHCO3 had a floating time of more than 12 hours. In vitro drug release kinetics of improved formulation F11 were discovered to be zero order, with anomalous diffusion coupled with erosion being the drug release mechanism. At the conclusion of 90 days, accelerated stability studies revealed negligible change in physicochemical attributes and drug release profiles, indicating that all the formulations were stable.
Clinical and subclinical features of 612 cases of hematospermia at hanoi medical university hospital
Authors: Bac Nguyen Hoai , Quan Pham Minh
Published: June 2022

Six hundred twelve patients with hematospermia were involved in a study to investigate the clinical and subclinical features of hematospermia. The average age of the patients was 39.42 ± 11.67 years. In the episodes of hematospermia, 22.45% of patients had a history of alcohol consumption. 16.25% of patients described a pattern of postponed or interrupted sexual intercourse before ejaculation. The rate of positive tuberculosis in PCR tests was 1.27%. 1.92% of patients had elevated total PSA. Positive culture accounted for 8.94 %. The testosterone level of these patients was relatively low for their age. While 26.01% of these patients had a decreased testosterone concentration (12.1nmol/L), 2.7% had low testosterone values (12.1 - 15 nmol/L).
Stability and safety study of liquid-suspension bacillus clausii spore probiotics (livespo clausy)
Authors: My Tran Thi , Dung Le Phuong , Lien Nguyen Thi , Anh Nguyen Thi Van , Anh Nguyen Hoa
Published: June 2022

Bacillus clausii has been used as probiotic bacteria in dietary supplements because of its prominent probiotic activities including its multi-antibiotic resistance, digestive enzyme production, vitamin synthesis, and immunomodulatory effects. In this study, heat and acid-stability, acute and sub-acute toxicity were conducted to evaluate the stability and safety of liquid-suspension probiotics (LiveSpo® Clausy, LiveSpo Pharma) containing ≥ 2 billion spores/5 mL of Bacillus clausii ANA39 strain. The result showed that the B. clausii ANA39 spores were heat- and acid pH-stable with the remaining survival rate of 60% and 40% at treatment conditions of 80oC and pH 2.0 for 20 min, respectively. Acute toxicity data in mice indicated LD50 was not detectable, even at extremely high dosage of 2.4 x 1010 CFU/kg, indicating LiveSpo® Clausy was in unclassified category. The sub-acute toxicity results showed that the rabbits administrated with B. clausii ANA39 at the dosages of 0.93 mL/kg rabbit/day (equivalent to 0.37 x 109 CFU ANA39 spores/kg rabbit/day) and 2.80 mL/kg rabbit/day (equivalent to 1.12 x 109 CFU of B. clausii ANA39 spores/kg rabbit/day) were healthy and steadily gained weight without any abnormal physiology and anatomy. Thus, LiveSpo® Clausy is resistant to high temperatures and low pH acids, stable for at least 24 months at room temperature, and safe for use as food supplements.
Effectiveness of communication intervention to improve the sexual function of pregnant women
Authors: Thanh Phan Chi , Cuong Tran Danh , Toan Ngo Van
Published: June 2022

Sexual dysfunction is common during pregnancy. This disorder will continue and worsened during the postpartum period, greatly affecting family happiness. The objective of the study was to access the effectiveness of communication and counseling interventions to improve sexual function of pregnant women. We used Female Sexual Functuin Function Index to assess sexual dysfunction for pregnant women. The study’s results showed that the FSFI score in the control group decreased by -2.5 (IQR: -7.2 to 0.2) points while in the intervention group, the decrease was only -1.1 (IQR: -5 to 2.6) points. This difference is statistically significant with p < 0.05. In the intervention group, pregnant woman who did not read media books or read less than 20% had the same reduction in FSFI scores after 1 month as the control group. The higher the reading level, the better the FSFI score. The risk of no intercourse during pregnancy in the control group was 2.81 times higher (95% CI 1.26 - 6.29) than in the intervention group. There was 64.0% of reduction in the risk of not having intercourse in the intervention group in comparison with the control group.
Port-site metastasis after laparoscopic radical nephrectomy for renal cell carcinoma: Report of 2 cases and review of the literature
Authors: Hoang Nguyen Huy , Thanh Do Truong , Long Hoang , Hung Le Van
Published: June 2022

Port site metastasis (PSM) after laparoscopic Surgery for Renal Cell Carcinoma is asporadic disease. At Viet Duc Friendship Hospital, the first case of renal cell carcinoma was operated by laparoscopic surgery in 2006. Since then, we have only recorded 2 cases of PSM. Case 1: Tumor recurred 17 months after laparoscopic radical nephrectomy with the diagnosis of sarcomatoid RCC T1bN0M0; Case 2: Tumor recurred three months after laparoscopic radical nephrectomy with the diagnosis of clear cell RCC T1bN0M0. We take this opportunity to review similar recurrence cases mentioned in the literature to understand further the causes, treatment methods, and experience in preventing this pathological phenomenon.
A case report of the first hereditary transthyretin cardiac amyloidosis diagnosed in Vietnam
Authors: Anh Duong Thu , Lan Nguyen Thi Ngoc , Ha Le Manh
Published: June 2022

Amyloid cardiomyopathy is a cardiovascular disease characterized by infiltration of amyloid into the heart muscle and other organs in the body, triggering impaired function of the heart and other organs. There are three main subtypes of amyloidosis including primary or AL amyloidosis, secondary or AA amyloidosis and hereditary or familial amyloidosis. Hereditary amyloidosis is less common, caused by an autosomal-dominant mutation most frequently in the transthyretin gene and has a more favorable prognosis.1,3 In this paper, we will be looking into a rare case of hereditary transthyretin amyloid disease with a genetic mutation (mutant TransThyRetin Amyloidosis - ATTRm), the first to be reported in Vietnam. That is a 47-year-old Vietnamese man with various clinical manifestations, including gastrointestinal disturbances (diarrhea, watery stool), periorbital purpura, macroglossia, autonomic neuropathy (dizziness, orthostatic hypotension, limb numbness, faint), and cardiovascular symptoms (dyspnea, leg edema, severe heart arrhythmias). The patient has a notable family history of many members appeared to have shown signs of the same disease and passed on without a diagnosis. A multimodality team in hematology, nuclear medicine, genetics, dermatology, and cardiology was assigned to the patient. We concluded that the patient was suffering from a form of ATTRm with a different genetic mutation from the common gene mutation in the world. Our patient is currently enrolled in a research program with a pharmaceutical manufacturer providing specific treatment and free medication. He is responding well to treatment and has shown signs of improvement.
Effect of Synchronized Lifestyle Modification Program and Physiotherapy in Improving Type 2 Diabetic Neuropathy patients having Increased Body Mass Index
Authors: Rameez Rubab , Ali Shazia , Chaudhry Tayyaba Anis , Shaukat Sidra , Zafar Ayesha , Iqbal Fatima
Published: June 2022

Background: Prevalence of diabetic neuropathy (DPN) is associated with increased Body Mass Index (BMI). Synchronized lifestyle modification program attempts to synchronize the circadian rhythm of the body through diet and exercise. Objective: Determine the role of Synchronized Lifestyle Modification Program (SLP) and Physiotherapy on fasting blood glucose (FBG), HbA1c, lipid profile, and degree of neuropathy in Type 2 DPN patients on Oral Hypoglycemic Agents (OHAs) having increased BMI. Materials and Methods: Randomized-controlled trial. Evaluation of 120 DPN patients on OHAs included, MNSI, BBS, FBG, HbA1c, Lipid profile and NCS. Participants divided into Group A and B, then divided into A1 and B1, that were overweight and A2 and B2, that were obese. B1 was divided into 1, 2 and 3 and B2 was divided into 4, 5 and 6. Groups 1 and 4 received SLP, Groups 2 and 5 received both SLP and Physiotherapy and Groups 3 and 6 received Physiotherapy for 12 weeks. p≤0.05 was considered significant. Results: MNSI, BBS, FBG, HbA1c, Total Cholesterol, TGs, HDL and LDL were significantly improved in Group 2. Conclusion: Combined Synchronized Lifestyle Modification Program and Physiotherapy is effective in DSPN patients that were overweight. Keywords: Diabetic neuropathy, Synchronized lifestyle modification program, Physiotherapy.
Comparison of Accuracy of IOL Master and a Scan Acoustic Biometry in Silicon Oil Filled Eyes
Authors: Anwar Faisal , Khan Asad Aslam , Majhu Tehseen Mahmood , Javaid Rana Mohammad Mohsin , Bokhari M. Hasan , Ghaffar M. Tahir
Published: June 2022

Objective: Objective of our study was to determine accuracy of IOL Master and A scan acoustic biometry in silicon filled eyes in terms mean difference of axial length pre-operatively and mean post-operative refractive error Study design: Comparative cross sectional study Study settings and duration: Study was conducted at department of Ophthalmology (Eye Unit III) Mayo hospital Lahore (KEMU) from November 2019 to April 2020. Material and methods: WHO calculator was used for calculation of patient sample (N=34). Patients were randomly divide in two groups Group I underwent preoperative axial length (AXL) measurement by using IOL Master and by acoustic a-scan ultrasound in Siliconized mode. Results: Total 34 patients were included in study. There were 18(52.9%) male and 16(47.1%) female. Mean age of patients was 44.2±6.4 years. Patients undergone biometry with Master IOL showed better visual acuity (Log Mar) (0.25±0.7, 0.63±0.09, p=0.000), less post-operative refractive error (0.22±0.02, 0.72±0.17, p=0.000) as compared to those in which A scan acoustic biometry was done. A significant difference in post-operative axial length was reported (p=0.04) Conclusion: IOL master is more accurate and reliable method of IOL power calculation resulting in better visual outcomes and less post-operative refractive error as compared to A scan acoustic biometry in silicon filled eyes. Keywords: A scan Acoustic biometry, Axial length, IOL Master
Normal Saline Versus Betadine use to Reduce the Incidence of Wound Infection in Cesarean Section, A Cross Sectional Comparative Study
Authors: Yasin Asma , Hussain Samar , Javeria Mehvish , Qurban Saima , Ashraf Muhammad Naim
Published: June 2022

Aims and Objectives: The aims and objectives of this study was to observed the difference between using betadine or normal saline irrigation of wound prior to skin closure in reducing the surgical site infections. Design of the Study: It’s a case-control study Study Settings: The study was conducted at Department of Obstetrics &Gynecology Rashid Latif Medical College, Lahore from June 2021 to November 2021. Material and Methods: For current study 200 pregnant women were selected and equally divided them into two different groups i.e. Group A and Group B. All individuals of Group A, used betadine liquid for surgical wound irrigation while the individuals of Group B, were used normal saline for such purpose. The observed raw data were statistically analyzed by SPSS 21, one –way ANOVA in which analysis of variance followed by mean standard deviation (Mean±SD) and P values (p<0.05) for significant. Results: The findings of current study indicated that wound irrigation with betadine liquid or normal saline have their own importance. The results are significant (p<0.05) in comparative analysis of Group A and Group B regarding allergy, postoperative wound cellulitis, postoperative wound abscess, postoperative fever and obstetric hemorrhages. Conclusion: The findings of current study indicated that Normal saline irrigation is better than betadine because of skin irritation and allergy due to iodine and toxicity of povadine iodine solution against healthy cells. Keywords: Cesarean delivery, surgical site infection, Normal saline, Betadine, surgical wound irrigation
Prevalence of Congenital Birth Defects among Pediatric Patients of Interior Punjab
Authors: Langah Azizullah , Hussain Abid , Baig Salman , Riffat Sumaira , Qureshi Jabbar Ahmed , Afreen Uzma
Published: June 2022

Objective: To find out the prevalence of congenital birth defects among the pediatric patients of Sialkot. Methods: A descriptive cross-sectional study was conducted at the pediatrics medicine, pediatric surgery and obstetrics ward of Khawaja Muhammad Safdar Medical College and hospital Sialkot Pregnant women irrespective of the parity were enrolled in the study. Demographic variables, detailed history and examination before and after delivery were noted on a preformed proforma. The data was entered and analyzed through Statistical Package for Social Science (SPSS) version 20. p-value less than 0.05 was considered as significant. Results: The mean age of the pregnant mothers included in the study was 25.45 ± 5.12 The most common age group affected was having age more than 30 years (58.1%) and majority were multiparous (52.4%). Cousin marriage was the most common factor leading to birth defects among their children and the result was significant (p-value ≤0.05). The prevalence of congenital birth defect was 14.7%. The cleft palate was the most common anomaly followed by hydrocephalus, cleft lip, down syndrome, polydactyly, undescended testes, club foot, microcephaly, meningyomyelocele, ambiguous genitalia and bradydactyly. Conclusion: The prevalence of congenital birth defect was 14.7% and cleft palate was the most common anomaly followed by hydrocephalus and down syndrome. The most common associated factor was cousin marriages.
Dental Anomalies in Children with Cleft Lip and Palate at a Tertiary Care Hospital
Authors: Ain Qurat-ul- , Malik Faiza , Khan Sumaira Anwar , Khawaja Hamna , Sadaf Ayesha , Qadeer Mustafa
Published: June 2022

Objective: To determine the dental anomalies in children with cleft lip and palate at a tertiary care hospital. Design of the Study: descriptive cross-sectional. Study Settings: Study was conducted at conducted in the OPD of Dentistry at Abbottabad International Medical Institute between the months of January 2021to June 2021. Material and Methods: The convenience sampling strategy was used to obtain the 208 radiographs of patients with cleft lip and/or palate for Data A. In order to conduct the study, the Institutional Review Board granted its approval. Radiographs were examined for suspected dental defects and demographic information was gathered. Results of the Study: A total of 76 (38 in group A and B) patients were included. Mean age in groups A and B was 39.25±3.91 and 38.71±4.01. Out of 38 patients in group A and B, effectiveness of large antecubital vein versus small vein on dorsum of hand in prevention of propofol injection was 81.6% vs. 36.87%. Conclusion: A high rate of dental abnormalities has been found in patients who have had a cleft lip or palate. The most common aberration in the study was tooth agenesis, with the lateral incisor having the highest rate of agenesis. Keywords: Dental Anomalies, Panoramic Radiograph, Cleft Lip and Palate
Comparison of Dental Caries and Gingival Bleeding Status among Diabetic and Non-Diabetic Type 2 Children
Authors: Afzal Muhammad , Anwaar Ali , Rana Adeel Ijaz , Ahmad Fareed , Azhar Shehnoor , Manzar Saadia
Published: June 2022

Objective: To compare the dental caries and gingival bleeding status among diabetic and non-diabetic type 2 children Design of the Study: Cross sectional study Study Settings: The current study was conducted in the OPD of Dentistry at the CMH Lahore between the months of January 2021 and June 2021. Material and Methods: A total of 400 children aged 6–18 years enrolled in the research. Children with Type 2 Diabetes Mellitus (T2DM) were included in the study group, whereas children without T2DM were included in the control group (non-diabetic group). Results of the Study: Among non-diabetic subjects, there were 191 (47.8%) males and 209 (52.2%) females respectively and among diabetic subjects, there were 198 (49.5%) males and 202 (50.5%) females respectively. Prevalence of teeth with dental caries among Non-diabetic subjects was found to be 87% (350) whereas among diabetic subjects, it was found to be 93% (371). Conclusion: According to the findings, diabetics were more likely than non-diabetics to have dental caries and periodontal disease. There was a high prevalence of dental caries and missing teeth in diabetic participants, which led to an overall higher mean DMFT score. Keywords: Gingival Bleeding, Dental Caries, Diabetic, Non-Diabetic, Children
Assessment of Knowledge about Halitosis and its Management Amongst Fresh Medical Graduates in Lahore, A Survey
Authors: Asghar Rija , Malik Aiman , Sadiq Muhammad Shairaz , Ahmed Fareed , Javed Mehek , Mir Bersha , Sohail Zaid Bin
Published: June 2022

Introduction: The origin of halitosis comes from the Latin word "Halitus" meaning 'breath, exhaled air.' Halitosis is an unpleasant odour exhaled in breathing, also known by the name of bad breath. The purpose of this research is to evaluate the level of knowledge of fresh medical graduates and their management skills towards halitosis. Methods & Materials: A questionnaire was designed to collect the required information from the fresh medical graduates. The duration of the study was 6 months January 2020 to June 2020. Study was conducted on fresh medical graduates from private and public sector across Lahore visiting the dental Outpatient Department of Institute of Dentistry, CMH Lahore Medical College Results: The study sample comprised of 59.3% females and 40.7% of males. Astonishing, 71.4% did not treat halitosis amongst patients visiting for treatment whilst 28.6% provided treatment for halitosis. Surprisingly, only 28.6% of medical doctors treated oral malodour. Alarmingly 71% doctor did not treat oral malodour. A whopping 95.2 % blamed poor oral hygiene to the biggest cause of halitosis. Stagnation of food secured 2nd place with 70% followed by chronic periodontal disease at 64.8%. Surprisingly, 0.4% mentioned that eating Garlic/raw food was considered as a least reason for oral malodour. Discussion: Conclusion: Halitosis was prevalent among patients visiting medical doctors for treatment. They can benefit from enhanced understanding and encouragement to improve their own and the patient's oral hygiene because of their responsibilities to diagnose and improve oral health..