bluuebunny/crossref_metadata_2025 huggingface dataset:
Análisis Documental de la Gestión Educativa: Influencias y Resultados
Authors: Ardila Ariza María Hasbleidy Alejandra , Carrillo Cruz Carlos Enrique
Published: January 2025

Este artículo presenta un análisis documental sobre la gestión educativa. El estudio caracteriza los resultados de la gestión y su influencia en la educación mediante la comparación. La recolección de datos se realizó a través de la codificación de artículos científicos y el establecimiento de categorías y variables. Los resultados muestran que la gestión educativa impacta positivamente en el pensamiento crítico, la equidad y la participación. En conclusión, es relevante profundizar en modelos estandarizados de gestión de alta calidad que sean flexibles y adaptables, permitiendo una implementación efectiva en diversos contextos educativos.
“In My Experience.. Innovations in Reverse Shoulder Arthroplasty: The Roles of The Greater Tuberosity and Deltoid”
Authors: Routman, MD Howard
Published: January 2025

The author discussions his views on innovations in reverse shoulder arthroplasty.
Análisis del Síndrome de Burnout en Docentes de la Ciudad de Guayaquil
Authors: Salmerón Yinis , Molina Castro Jorge , Gary Murillo Wilvir , Martínez Martínez Erika , Salazar Navarrete José
Published: January 2025

La presente investigación buscó determinar la presencia de sobrecarga de trabajo en docentes de la ciudad de Guayaquil y la relación que tiene esta con el síndrome de Burnout, con el único objetivo de analizar el indicio por medio de un estudio estadístico comparativo y explicar la técnica de inoculación de estrés para lidiar con él de un modo efectivo. Según los estudios realizados en algunos países de América Latina se ha observado que los índices de Burnout son elevados, lo cual varía dependiendo de los climas sociales a los que los docentes se encuentran expuestos a diario, así como también muchos factores psicosociales, esto incluye factores psicosomáticos, con influencia en las relaciones laborales, sociales y personales. Para llevar a cabo esta investigación se utilizó dos tipos de encuestas, se contó también con la participación de docentes de cuatro unidades educativas. Según los resultados, un cierto porcentaje de docentes sufre de Burnout, algunos mostrando despersonalización, otros, agotamiento laboral. El estudio es cuantitativo, midiendo la efectividad de las respuestas por medio del Alpha de Cronbach, y un estudio descriptivo, como conclusión, se trató de justificar la importancia de formar a los futuros docentes en encarar competencias emocionales, no sólo de prevenir el burnout, sino también de lograr el éxito personal en las distintas circunstancias de la vida.
Comunidades Ribeirinhas Amazônicas e a Expansão do Agronegócio
Authors: Maciel de Araújo João
Published: January 2025

Os dois últimos verões amazônicos (2023 e 2024) impressionam o mundo devido a seca severa que atinge a porção ocidental da Amazônia brasileira. O baixíssimo volume de água dos rios criou uma paisagem desoladora e aterrorizante, transformando o cotidiano de comunidades ribeirinhas e de toda a sociedade regional. Este trabalho busca provocar a reflexão acerca da realidade de comunidades ribeirinhas estabelecidas nos vales dos rios Madeira e Purus, no Sul do estado do Amazonas. Por meio de uma abordagem relacional, com dados produzidos a partir de levantamento documental, entrevistas abertas e observação direta realizadas entre janeiro de 2023 e agosto de 2024, em seis comunidades (três em cada vale), a pesquisa lança luz sobre as rupturas e continuidades do processo histórico de (re)existência de um campesinato ribeirinho nesta região, pressionado pelo avanço do agronegócio e dos recentes eventos climáticos. Os dados revelam que os sistemas simbólico-práticos que orientam estas comunidades são também portadores de elementos para imaginar um futuro possível para a Amazônia.
Komunikasi Efektif Dalam Keperawatan : Strategi Penggunaan Bahasa Yang Sederhana Edukasi Pasien
Authors: Al Jamiliyati Nasikhatul Ulla , N.A Septia Rizqi , Hayunnisa Rizky , Eka Salsabila , Farihatul Sintia , Rochma Siti , Sofia
Published: January 2025

This article discusses the importance of effective communication in nursing, especially the use of simple language in patient education. Effective communication, using language that is easy to understand, increases patient satisfaction, reduces anxiety, and increases adherence to treatment. Literature studies show that clear and empathetic communication reduces the risk of medical errors, increases patient participation in care decision making, and results in better care outcomes. This article suggests effective communication strategies such as active listening and the use of visual aids to achieve optimal results. In conclusion, effective communication using simple language is the key to quality and holistic patient care.
Analysis of the Implementation of SP4N-LAPOR Policy as a Form of Public Service Reporting Mechanism at Diskominfo of Southeast Sulawesi Province
Authors: Andi Fatwa Mahdika Candra  , Hartono Supri , Ilman Ghulam Maulana
Published: January 2025

E-government implementation is a strategic step to create transparent, accountable and efficient governance. One of the main programs that support this achievement is SP4N-LAPOR (National Public Service Complaint Management System), a digital platform that provides access to the public to convey aspirations and complaints related to public services. This research focuses on analyzing the implementation of the SP4N-LAPOR policy at the Diskominfo of Southeast Sulawesi Province, using Edward III's policy implementation theory based on four assessment indicators Communication, Resources, Disposition, Bureaucratic Structure to identify the effectiveness of its implementation and reveal supporting and inhibiting factors. The results showed some significant challenges in implementing this policy. From the communication aspect, the lack of socialization has led to a lack of understanding among the public and government officials regarding the mechanism of using SP4N-LAPOR. Limited resources, both in terms of the quality of human resources and budget, are also an obstacle. The fragmented bureaucratic structure and lack of coordination between agencies exacerbate the situation. In addition, the non- uniform attitude of policy implementers or disposition shows that some agencies have not prioritized the use of this platform. However, there are also supporting factors, such as national regulations that support the implementation of SP4N-LAPOR, governor instructions, and the availability of digital systems that facilitate the management of public reports. This study concludes that SP4N-LAPOR implementation in Southeast Sulawesi still needs improvement. The low report completion rate indicates the need to strengthen human resources through training, budget increases, and more equitable development of information technology infrastructure. Socialization to the community must also be improved to encourage active participation in reporting complaints. This research not only makes a theoretical contribution to the study of E-government policy implementation but also offers practical recommendations to improve public complaint management.
https://www.ijppna.org/post/editorial-du-pr-serigne-omar-sarr-ijppna-vol-02-n-04
Authors: DOFFON, et al.. Parfait Mahugnon
Published: January 2025

Abstract: To study the quality of the honeys consumed in the city of Cotonou, physico-chemical and microbiological analyses were carried out on thirty-two (32) samples of honey of different brands marketed in the supermarkets of the city of Cotonou, of which twenty-seven (27) brands were locally produced. These honey samples were collected in seven (07) districts of the city of Cotonou.

The study of labeling was done by visual inspection; the physico-chemical parameters analyzed were density, pH, water content, electrical conductivity, free acidity and level of Hydroxy Methyl Furfural (HMF). Five (05) microbiological parameters: yeasts and molds, salmonella, sulphite-reducing anaerobic bacteria (Clostridium spp), Escherichia coli and Total Mesophilic Aerobic Flora (FAMT) were determined in each sample.

93.75% of samples analyzed did not fulfill the recommended mentions on their labels. The determination of the physico-chemical parameters of the honeys showed pH values varying between 3.50 and 6.83 and electrical conductivity between 0.142 and 1.351. The density of the honeys analyzed varied between 1.205 and 1.456 and HMF content ranged from 3.0 to 223.7 mg/kg; the free acidity values were between 4.67 and 71 meq/kg and the insoluble matter content varied from 0.063 g to 0.719 g per 100 g of honey.

According to the specifications relating to honey in Benin, the microbiological analysis showed that for 65.63% of our samples the microbiological quality were not acceptable: 59.38% contained several total mesophilic aerobic flora, 18.75% contained salmonella and a number of yeasts and molds that exceeded the standards; 9.38% contained bacteria of the Clostridium genus and 3.13% contained Escherichia coli strains.

Key words: honey, quality, Cotonou, physico-chemical and microbiological analysis.
Etude de la qualité de médicaments à base d’oméprazole commercialisés au Sénégal
Authors: TIRERA Harouna
Published: January 2025

Abstract: Omeprazole is a medicine used in the treatment of peptic ulcer disease with an estimated prevalence of 10% of the adult population worldwide. In Africa, the data are fragmentary and vary depending on the series. In Senegal, it is estimated at 12.4% in 2011. Its treatment involves the use of antiulcer drugs. The objective of the present study was to evaluate the quality of omeprazole-based medicines. The study focused on 20 samples of omeprazole-based medicines collected from private pharmacies, hospital pharmacies and health centers in the city of Dakar. Physical and visual inspection, pharmacotechnical tests and dosage of the active ingredient were carried out. The results showed that the samples complied with the mass uniformity test and 85% had a compliant water content, 15 of the 20 samples collected had an active ingredient content compliant with the standard, i.e. 75% .Thus, the majority of samples tested were found to comply with the tests. However, the study was carried out on a limited number of samples and given the global context of drug quality, more detailed monitoring by the national medecines regulatory authority is recommended.
Knowledge, Attitudes and Practices of Surgical Trainees and Trainers on Recommended Surgical Site Infection Prevention Protocols
Authors: Saguil Esther , Abellera Jose Modesto , Florendo Daniel Ernest , Uyquienco George Robert
Published: January 2025

Rationale/Objective:
This study aimed to determine the knowledge, attitudes and practices of surgeons and surgical trainees regarding published SSI prevention guidelines. Specifically, the study described knowledge and attitudes towards SSI prevention guidelines among members of surgical training programs, described preoperative, intraoperative, and postoperative practices in SSI prevention and identified the presence of surgical site infection surveillance programs among various institutions

Methods:
This was a retrospective cross-sectional study that evaluated the knowledge, attitudes, and practices of surgeons and surgical trainees to published SSI prevention guidelines in the Philippines. It utilized existing data from an October 2022 online survey done by the Philippine College of Surgeons distributed to various surgical training institutions in the country.

Results:
There were a total of 213 respondents. The different attitudes and knowledge gaps towards present SSI prevention guidelines are described

Conclusion:
Despite the existence of local and international guidelines there still appears to be a significant lack of awareness and variability in practice among the different institutions as well as with surgeons of different levels of expertise or training. Varying preoperative, intraoperative and postoperative practices have also been described, including evident deviations from SSI guidelines. Lastly, there is a lack of standardized SSI surveillance programs among institutions and these are not aligned towards improved patient safety and quality improvement.
Exploring ChatGPT as a Tool for Thesis Writing: Perspectives of EFL Supervisors in Jordanian Universities
Authors: Rababah Mahmoud Ali
Published: January 2025

This study examines Jordanian EFL supervisors' views on ChatGPT's usage and effects on thesis writing at private and public universities in Jordan. A questionnaire was used to collect data from 47 EFL supervisors. Closed-ended Likert-scale questions were used to quantify supervisors' opinions on ChatGPT's correctness, dependability, and usefulness in thesis writing. Supervisors gave varied views on ChatGPT's usefulness and effects on thesis writing. They agreed that ChatGPT helps students generate ideas, enhance their vocabulary, and improve their thesis writing skills. Supervisors were impartial to ChatGPT's ability to assist students in organising the thesis, delivering arguments, and overcoming writer's block. The findings also showed conflicting opinions on ChatGPT's thesis organization comments and their influence on students’ autonomy. Supervisors perceive ChatGPT's influence on supervisor-student interactions differently. The study adds to technology integration in EFL writing teaching, especially thesis writing. It quantifies supervisors' ChatGPT impressions to understand numerical trends and patterns. The results may help educational institutions and policymakers integrate ChatGPT into thesis-writing pedagogy.
Attracting and Retaining International Students in Iranian Universities: Pathology, Prerequisites and Requirements
Authors: Eynolahi Masoum Bahram
Published: January 2025

Today, attracting international students, beyond its imported currency, is a determining factor in achieving the strategic aims of countries. In this sense, the internationalization of universities can be a route to Iran's ascension in the world power cycle. With this consideration, the current article has a comprehensive look at the issue of attracting and retaining international students. In this order, the first part of the research is devoted to the context and situation of Iran in attracting and retaining international students, by explanatory and interpretative methods. By considering current problems and challenges facing this issue, along with the pathology of the existing situation, it has been explained and the material and immaterial prerequisites and requirements of attracting and retaining international students at macro and micro levels, in the second part, in such a manner that it has been prescribed necessary structures and infrastructures of attracting and retaining international students in material, immaterial and legal aspects. Finally, by considering the mentioned situation, challenges, prerequisites, and requirements, some strategies have been presented for attracting and retaining international students at both macro and micro levels, by inference from the content of the research. Adopting appropriate policy-making related to preparing the mentioned prerequisites and requirements can be a problem solver, at both fundamental and functional levels. Also, it can improve the situation and procedure of attracting and educating international students, quantitatively and qualitatively, by preserving and promoting the international credit of Iranian universities. The approach of this article is critical, in the analysis of existing situations, and is creative in strategizing.
The Salt and Dust of the Aral Sea Could Turn Central Asia into A Second Sahara
Authors: Bahodir Asomovich Kamolov
Published: January 2025

The Aral Sea is located in the heart of Asia, in Central Asia, spanning the western part of Kazakhstan and the northwestern part of Uzbekistan. It is a transient lake that emerged in its current location approximately 600–700 years ago. Until the 1960s, the surface level of the Aral Sea continued to rise due to the inflow from the Amu Darya and Syr Darya rivers.
bello y lo útil
Authors: Durán Cecilia
Published: January 2025

El pueblo tiene derecho a la belleza. Artes aplicadas, educación e industria en Buenos Aires (1910-1940).
Mantovani, Larisa. Buenos Aires, Argentina: Miño y Dávila Editores, 2023, 384 páginas.
Formulation of Larvicide from Capsicum frutescens (Linn.) Fruit Extract Against Aedes aegypti (L.)
Authors:   College of Pharmacy, University of the Philippines Manila, Pedro Gil St., Ermita, Manila City, Philippines, Soria Marie Claire , Argonza Femina Grace ,   College of Pharmacy, University of the Philippines Manila, Pedro Gil St., Ermita, Manila City, Philippines, Claros Christine ,   College of Pharmacy, University of the Philippines Manila, Pedro Gil St., Ermita, Manila City, Philippines, Quiming Noel ,   College of Arts and Sciences, University of the Philippines Manila, Pedro Gil St., Ermita, Manila City, Philippines, Alvarez Michael Russelle ,   Institute of Chemistry, College of Arts and Sciences, University of the Philippines Los Baños, College, Laguna, Philippines, Balotro Bienvenido ,   College of Pharmacy, University of the Philippines Manila, Pedro Gil St., Ermita, Manila City, Philippines
Published: January 2025

The crude ethanolic extract of Capsicum frutescens fruit was used in the formulation of larvicidal granules. The extract was first screened for phytochemical content and larvicidal activity against Aedes aegypti. Five trial formulations were developed using different combinations of excipients identified to be compatible with the active extract. These formulations were evaluated using Quality by Testing (QbT) Method (organoleptic evaluation, moisture content, powder flow property, particle size distribution, dissolution in water and larvicidal bioactivity). The C. frutescens extract (500 ppm) killed 100% of the test larvae after 24 and 48 h. Phytochemical analysis revealed the presence of steroids, indoles, alkaloids, flavonoids, sugars, coumarins and anthraquinones. Among the formulations tested, formulation # 5 (25% extract, 59% lactose, 1% 5% PVP-ethanol solution, and 15% microcrystalline cellulose (MCC) was the most active, with LC50-24 h=108.68 ppm, LC90-24 h=233.44 ppm, LC50-48 h=102.68 ppm, and LC90-48 h=182.50 ppm. Larvicidal granules (Formulation #5) against A. aegypti were developed. The granules were able to kill 100% of the test larvae after 24 and 48 h of exposure. In addition, the formulation passed all the quality control measurements (low moisture content, excellent powder flow, soluble in water, and 90% cumulative frequency within 0.420–0.841 mm).
The use of deep learning in intelligent athlete motion recognition: Integrating biological mechanisms
Authors: Zhang Ming , Li Yanfeng , Cui Yuhong
Published: January 2025

This work explores the effective application of deep learning for recognizing athletes’ movements, aiming to enhance precision in competitive sports. Traditional motion analysis methods primarily rely on manual observation, which can introduce subjective bias and limit accuracy. To address these limitations, we propose an automated method based on deep learning for recognizing and classifying athletes’ technical movements while evaluating their performance. A hybrid model, combining Convolutional Neural Networks (CNN) and Long Short-Term Memory (LSTM) networks, is utilized to extract key frames from video data. The CNN is responsible for feature extraction, capturing the intricate details of movement, while the LSTM captures the temporal sequence characteristics, providing context to the actions. To further strengthen our approach, we delve into the biological mechanisms underlying athletic movements. Understanding the biomechanics of motion—such as joint angles, muscle activation patterns, and energy expenditure—can enhance the accuracy of deep learning models. By integrating these biological insights into our model, we improve the recognition process, allowing for a more nuanced understanding of how movements impact performance. Through experiments, we demonstrate that the model achieves high accuracy across multiple benchmark datasets (UCF-101, HMDB-51, Kinetics-400, and Sports-1M), with a particularly high accuracy of 93.5% on the UCF-101 dataset. These results indicate that the proposed method is both accurate and reliable, making it suitable for athlete training and competition analysis. The findings of this research have significant implications for sports science, training evaluation, and injury prevention. By providing coaches and athletes with precise feedback based on deep learning analysis, we can facilitate targeted training interventions that enhance performance while reducing injury risks. This work aims to offer a powerful tool for athletes, coaches, and researchers, contributing to the advancement of competitive sports through a deeper understanding of movement dynamics and their biological underpinnings.
The effect of core strength combined with sensory integration training on the walking ability of children with cerebral palsy
Authors: He Weiqi
Published: January 2025

Objective: To compare the influence of core strength training combined with sensory integration training and routine rehabilitation training on the walking ability of children with cerebral palsy, and to provide a basis for the selection of reasonable rehabilitation training for them. Methods: Thirty children with cerebral palsy aged 7–12 years were randomly divided into an experimental group (15) and a control group (15), with the former conducted for 8 months of core strength training and sensory integration training three times a week, and the latter conducted for the same period of conventional rehabilitation therapy training three times a week. Besides, the research respectively investigates the gross motor function measure (GMFM), parameters of gait, physiological consumption index as well as the balance and postural control of the children in the two groups before and after the training. Results: (1) The scores of GMFM-D and GMFM-E are increased in the experimental and control groups after the intervention, with the former achieving higher scores than the latter (p < 0.01); (2) All parameters of gait improved in both groups after the intervention, the experimental group showing better improvement than the control group in terms of stride length, width, left and right support phases and swing phase(p < 0.05) (3) The physiological consumption index of the experimental group was significantly lower after training (p < 0.05). (4) The COP of the experimental group was remarkably higher than that of the control group after training (p < 0.05). Conclusion: Core strength combined with sensory integration training and conventional rehabilitation training can improve the motor function and walking capacity of children with spastic cerebral palsy, but the former method has a better intervention effect.
“课程思政”视域下职业院校体育教师队伍建设的困境与策略
Authors: Feng Zhibo , Huang Fei
Published: January 2025

职业院校体育教师队伍建设事关“三全育人”综合改革工作目标，事关“立德树人”根本任务的完成和时代新人的培育。客观审视职业院校体育教师队伍建设的机遇与挑战，发现新时代背景下职业院校体育教师队伍建设存在师德弱化、能力不足、地位边缘、培训偏离的现实问题。对此，要积极优化队伍管理和师德考核，提升科研水平和数字技术，完善激励政策和工资待遇，加大政策支持和制度保障，加强业务培训和体育进修，以促使体育教师队伍切实发挥出强大的体育育人正能量。
高校党建工作在引导大学生网络舆情中的作用探究
Authors: Zhou Jianming , Wang Jingwen
Published: January 2025

本文通过分析高校党建工作在大学生网络舆情中的引导作用，探讨了高校党组织如何发挥其政治优势和思想引导功能，以应对互联网时代下大学生群体对信息的强烈需求及网络舆情的挑战。文章首先回顾了网络舆情的定义、特征及其对大学生的影响，继而分析了高校党建工作在引导大学生网络舆情中的作用，最后提出了加强党建工作在网络舆情引导中的创新路径。研究表明，党建工作能够通过增强大学生的政治意识、道德责任感和网络安全意识，有效提高他们的舆情辨识能力和引导能力，为维护校园网络的健康发展发挥重要作用。
Quantification of visceral fat deposition: Comparison of conventional and local bioimpedancemetry in the abdominal region
Authors:   Lopukhin Federal research and clinical center of physical-chemical medicine, Bondareva Elvira , Parfenteva Olga ,   Lopukhin Federal research and clinical center of physical-chemical medicine, Gadzhiakhmedova Aida ,   Lopukhin Federal research and clinical center of physical-chemical medicine, Generozov Eduard ,   Lopukhin Federal research and clinical center of physical-chemical medicine,, Komshilova Kseniya ,   Endocrinology Research Center, Mazurina Natalya ,   Endocrinology Research Center, Ershova Ekaterina ,   Endocrinology Research Center, Troshina Ekaterina
Published: January 2025

The aim. Analysis of the relationships between local bioimpedance measurements and quantitative estimates of visceral fat deposition
obtained by various indirect methods.
Material and methods. The program included measurement of anthropometric features and determination of body composition in traditional
(octopolar for 770InBody and tetrapolar for ABC-02 Medas) and local schemes in the abdominal area (ABC-02 Medas). The 770InBody
analyzer was used to determine the visceral fat area (VFA), and the ABC-02 Medas – for local impedances in the subcutaneous (Z_sc) and
visceral (Z_visc) leads.
Results. A cross-sectional continuous study was conducted at the National Medical Research Center of Endocrinology of the Ministry of
Health of the Russian Federation. A total of 48 people (38 women and 10 men) aged 24 to 74 years were examined using a single program.
A comparative analysis of a set of features in the subgroups of men and women was carried out. Sexual dimorphism was not detected for
the features characterizing visceral fat deposition (BF10 <3.0). A positive dependence close to linear was observed between the features;
the nature of the relationship in the subgroups of men and women did not differ. Correlation analysis revealed a strong relationship between
local impedances and VFA (0.751 [0.594; 0.853] and 0.819 [0.697; 0.895]). Analysis in subgroups with different nutritional status revealed
significant differences (p <0.001) for all the studied features. Subgroups with grade 1 and 2 obesity do not differ in all studied characteristics,
whereas subgroups with underweight, normal body weight, and morbid obesity demonstrate significant differences.
Conclusion. The results of the conducted study allow us to conclude that local BIA leads in the abdominal region, obtained on a domestic
analyzer, have a strong correlation with other signs characterizing visceral fat deposition (VFA, SAD, WC)
Adrenocortical cancer: Prognosis, treatment and immune microenvironment
Authors:   Endocrinology Research Centre, Pachuashvili Nano , Porubayeva Erika ,   Endocrinology Research Centre, Urusova Liliya ,   Endocrinology Research Centre
Published: January 2025

Adrenocortical cancer (ACС) is a rare malignant endocrine tumor from cells of the adrenal cortex with an incidence of 0.7–2 cases per
1 million population per year. Due to difficulties in diagnosis, ACС is detected already at the stage of metastasis, which limits the possibilities
of surgical intervention and implies an unfavorable prognosis. The composition of the tumor microenvironment is crucial for the development
of strategies for immunotherapeutic treatment of cancer. One component of the tumor microenvironment is immune cells, the presence of
which is often associated with a better prognosis for patients. The purpose of this review is to describe the current possibilities for predicting
the course and treatment of patients with ACC, as well as to focus on the latest published data on the immune microenvironment of the tumor in order to give some ideas about the prospects for its use for personalized patient management.
Medical treatment of obesity: Modern approaches and prospects
Authors:   Pirogov Russian National Research Medical University, Titova Victoria , Ushanova Fatima ,   Pirogov Russian National Research Medical University, Demidova Tatyana ,   Pirogov Russian National Research Medical University
Published: January 2025

Obesity is a chronic progressive disease that poses a major problem for modern healthcare due to the high and rapidly growing prevalence
and development of severe complications such as cardiovascular diseases, type 2 diabetes mellitus, malignant neoplasms, etc. Effective
treatment of obesity requires an integrated approach, where drug therapy and, in some cases, bariatric intervention complement lifestyle
measures – nutrition correction and the use of regular physical activity. Successful treatment of obesity requires an individual approach
to the patient, taking into account the initial body weight, the presence of risk factors or developed concomitant diseases, as well as the
dynamics of weight loss during therapy. Drug therapy is an important part of the treatment of obese patients, because it allows you to achieve
a more significant result of weight loss, and, importantly, to maintain a reduced weight. Drugs of the GLP-1 agonists, widely used today in
the treatment of obesity, not only directly affect body weight, but also reduce the risks of severe cardiovascular diseases and metabolic
disorders, thus leading to an improvement in the quality of life and an increase in its duration. The article presents the main approaches to the treatment of obese patients with a description of the modern possibilities of pharmacological treatment of obesity.
The role of glucagon-like peptide-1 receptor agonists in cardiometabolic health management
Authors:   Pirogov Russian National Research Medical University, Demidova Tatiana , Nikitin Igor ,   Pirogov Russian National Research Medical University, Kislyak Oksana ,   Pirogov Russian National Research Medical University, Starodubova Antonina ,   Pirogov Russian National Research Medical University
Published: January 2025

Glucagon-like peptide-1 receptor agonists (GLP-1) represent an innovative class of hypoglycemic drugs, the clinical effects of which have gone far beyond glycemic control. The wide prevalence of GLP-1 receptors in organs and tissues of the human body provides many clinically significant pleiotropic effects of GLP-1. The results of a series of large randomized clinical trials demonstrated the high efficacy, good tolerability and safety of GLP-1 agonists in the management of cardiometabolic health, which determined their preferential position in clinical guidelines. A special place in the line of drugs of the GLP-1 receptor agonist class is occupied by liraglutide and semaglutide, due to their special additional effects on weight loss and effect on major cardiovascular outcomes, which allowed to expand the indications for their use in the treatment of obesity and reduction of CVD and overall mortality. The article presents a literature review of current data on the mechanisms of action and metabolic effects of GLP-1 receptor agonists.
Cardiac Manifestations of Coronavirus (COVID-19)-An Updated Review for Healthcare Professionals
Authors: Alrakkad Abdullah Abdulkarim , Al-Hamzani Abdulaziz Menwer , Alsalman Laila Hassan Abdullah , Hospital Muzahmiyah General , Alotaibi Mohammed Abdulah , Alanazi Fatimah Ahmed Hattab , Bakaralanzi Eidh Khalaf , Al Salman Laila Hassan , Somily Sultan Mohammed , Ayyashi Yasir Jubran Mousa , Alqahtani Jamla Omar , Alomar Khalid Abdualiziz , Khormi Hayat Gazy , Alrakkad Abdullah Abdulkarim , Al-Hamzani Abdulaziz Menwer
Published: January 2025

Background: Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, primarily affects the respiratory system, but also presents significant cardiac manifestations. While acute respiratory symptoms are typical, COVID-19 is linked to numerous cardiovascular complications such as ischemic heart disease, arrhythmias, heart failure, and myocarditis. These complications, particularly in individuals with preexisting cardiovascular conditions, are associated with poorer outcomes. Aim: This review aims to comprehensively explore the cardiac manifestations of COVID-19, evaluate their pathophysiology, and assess current treatment strategies for managing these complications. Methods: This updated review consolidates findings from recent studies on the cardiovascular impact of COVID-19, drawing from clinical, epidemiological, and pathophysiological data. Literature sources were reviewed from various academic and clinical studies focusing on the prevalence, diagnosis, and management of cardiac issues associated with COVID-19. Results: COVID-19-related cardiac complications, including acute cardiac injury, myocarditis, arrhythmias, and heart failure, have been reported across multiple studies. The prevalence of cardiac injury among hospitalized COVID-19 patients ranges from 22% to 30%, with a notable increase in those over 60 years old. Acute coronary syndrome and arrhythmias are particularly common in older patients with preexisting cardiovascular risk factors. Post-mortem studies reveal myocardial necrosis, edema, and endothelial damage, suggesting a multifactorial pathophysiology involving inflammation, thrombosis, and viral invasion. Conclusion: COVID-19 presents a complex challenge for healthcare professionals due to its significant cardiovascular impact, particularly in patients with pre-existing heart conditions. Cardiac complications must be closely monitored, and appropriate management strategies are critical in improving patient outcomes. Future studies should focus on refining diagnostic methods and exploring long-term cardiac health in post-COVID-19 patients.
Uric Acid Nephrolithiasis: An Updated Review
Authors: Al-Qahtani Haya Muhammad , Aldosari Noura Saad , Almalki Turki Mohammad Hasssan , Al Haili Sarah Bhni Mohamed , Hakimi Amal Jadah Abu Al-Qasim , Alharthi Khalid Ayed Aoudh , Nabush Marwah Mohammed , Hakami Adel Ali , Aldawsari Fahad Nigiri , Aldalbahy Naya Shujaa , Aldawsari Fahad Nigiri , Al-Ghamdi Mohammed Ali Abdul Hadi , Alhuwaymil Sultan Abdullah , Al-Mutairi Jazaa Mohsen , Maslof Mohammed Ahmed Hassan
Published: January 2025

Background: Uric acid nephrolithiasis is a prevalent condition marked by the formation of kidney stones from uric acid crystal deposition. This disorder is often linked to hyperuricemia and acidic urine, with multiple risk factors, including obesity, diabetes, hypertension, and metabolic syndrome. Uric acid stones, which account for 5-40% of urinary stones globally, have historically caused significant pain and require advanced treatments. Aim: This review aims to update the understanding of uric acid nephrolithiasis, focusing on its etiology, epidemiology, pathophysiology, and current treatment strategies. Methods: The review synthesizes data from numerous studies on the biochemical formation, risk factors, and management of uric acid stones. It emphasizes the role of urinary pH, hyperuricosuria, low urine volume, and genetic predispositions in stone formation. The impact of diet, genetic disorders, and environmental factors is also discussed. Results: Uric acid stones primarily form under conditions of low urinary pH, which impairs the solubility of uric acid. Diets high in purines, dehydration, and metabolic disorders significantly increase the risk of stone formation. Key risk factors include hyperuricosuria, obesity, and acidic urine. Advances in treatment now allow the dissolution of many uric acid stones by increasing urinary pH and volume while managing hyperuricosuria. However, recurrence remains common, and the condition is associated with high healthcare costs. Conclusion: Uric acid nephrolithiasis remains a significant clinical challenge with diverse etiology and risk factors. Early diagnosis and intervention, including dietary modifications, adequate hydration, and medical management to increase urinary pH and reduce uric acid levels, are crucial in preventing recurrence. Continued research into the molecular mechanisms of stone formation and novel treatments is essential for improving patient outcomes.
Peculiarities of cryptocurrency functioning
Authors: Ishchuk Lesia , Ishchuk Viktoria
Published: January 2025

The article points out the prevalence of cryptocurrencies in modern society and explores the peculiarities of their use. The systematization of literary sources, foreign experience and market data shows that there is a debate and certain differences in the understanding and interpretation of the essence of cryptocurrency, which affects its introduction into business activities and use by citizens both at the legislative level and by the financial system. The urgency of solving this problem lies in the fact that the state must respond quickly to changes in society and adapt to them, preventing negative consequences, first of all, for the state itself, as well as for ordinary citizens. The methodological basis of the study is the use of methods of analysis, synthesis, theoretical generalization, economic and statistical methods. The article identifies the main features of cryptocurrency as a phenomenon and ways of its use. The expediency of its introduction into legal circulation is substantiated. The negative aspects that harm the financial system of the state and the factors that help the latter to develop are highlighted. Foreign experience of regulating the use of cryptocurrency and its taxation is presented, which has a positive impact on the legal and financial spheres of state activity. Given the identified weaknesses and strengths of cryptocurrencies, the threats to the use of cryptocurrencies and further opportunities for it are formulated. The article examines the current state of development of the cryptocurrency market and compares it with the market of 2017: the price, market capitalization and percentage of the total market capitalization of cryptocurrencies are analyzed. The article lists possible investment activities related to cryptocurrency. The impact of cryptocurrencies on the environment is studied. The necessity of state intervention in regulating the circulation of cryptocurrencies is indicated, finding options for overcoming the consequences of the weaknesses of cryptocurrencies
مروری بر خواص معالجوی توکسین‌های کلستریدیوم بوتولینوم
Authors: نیازی عبدالجاوید
Published: January 2025

کلستریدیوم بوتولینوم یک عامل بیماری‌زای عمده­ بوده که با تولید هفت نوع توکسین عصبی (A-G) سبب بیماری شدید و کشنده در میزبان‏های مختلف به‏شمول انسان می­­گردد. افزون بر ایجاد بیماری نتایج تحقیقات اخیر مؤثریت تطبیق برخی از این توکسین­ها را به دوز­های پایین غرض تداوی یک تعداد اختلالات در انسان‏ها  ثابت ساخته است. در این مقاله­ی مروری آخرین مقالات علمی نشر شده در ژورنال­های معتبر بین­اللملی پیرامون مؤثریت توکسین­های باکتری متذکره در تداوی برخی حالات مشخص در انسان‏ها مرور و از نتایج مشخص آن‏ها استفاده به عمل آمده است. نتایج مطالعات مختلف نشان می­دهند که علاوه بر خاصیت شدید و کشنده­ی توکسین­های کلستریدیوم بوتولینوم، یک تعداد توکسین­ها به‌ویژه توکسین­های نوع A و B (خصوصاً بوتاکس) استفاده­­های وسیع­ معالجوی دارند و در تداوی اختلالات مختلف در انسان‏ها استفاده می­شوند که نظر به سایر روش­ها ارزان، مصؤن و مؤثر بوده و تطبیق آن نیز آسان می­باشد.
د لوړو زده کړو په بنسټونو کې د ديني او ملي ارزښتونو د پياوړتيا څرنګوالی
Authors: ستانکزی ميرويس
Published: January 2025

په دې مقاله کې په تحصيلي بنسټونو کې د ديني او ملي ارزښتونو څرنګوالی او د پياوړتيا لارې چارې په تحليلي مېتود څېړل شوي، د افغاني ټولنې له پاره د ديني او ملي ارزښتونو پالنه اړينه ګڼل کېږي، د څېړنې له پايلو ښکاري چې تحصيلي بنسټونو کې له ديني او ملي ارزښتونو څخه موخه د دين په رڼا کې دنيوي اړتياوې په معقول ډول تنظيمول او پياوړي کولو غوره لاره يي په تحصیلي نصاب کې د ديني لارښوونو ځای پر ځای کول دي؛ چې د ديني او ملي ارزښتونو په پياوړي کولو سره د ژمنو او وړ کادرونو روزنه وشي او راتلونکي نسلونه د ديني فکر او ملي هويت په ګاڼه سمبال شي، دا راز په متوازن ډول ورته پاملرنه نه کول ناخوالې له ځانه سره لري.
نقش تحصیلات عالی در تحقق اهداف انکشاف پایدار
Authors: منصوری احمدمسعود , امین روح‌افزا , برمک بهزاد
Published: January 2025

آجندای اهداف انکشاف پایدار در یک بُرهه‌ی حساس تاریخ معاصر، مطرح می­گردد که جهان با موانع فراوانی روبه­رو است. فقر و گرسنه‌گی، بی­کاری و نابرابری، خشونت و بی­عدالتی، ناامنی و بی­ثباتی ـ از جمله چالش‌های بزرگ جهان امروز محسوب می­شوند. برعلاوه، ضعف حکومت­داری خوب و فساد گسترده، عدم شفافیت و پاسخ­گویی، عدم تناسب رشد نفوس و اقتصاد، عدم دست­رسی به انرژی پایدار و آب آشامیدنی صحی، مایه­ی نگرانی جهان بشریت به ویژه افغانستان می‌باشد. انکشاف پایدار یکی از الزامات اساسی هر جامعه است که تکیه بر دانش بشری و سازمانی داشته و برمبنای پالیسی و استراتیژی دولتی تحقق می­یابد که شامل ابعاد مختلفی چون؛ اقتصاد، امنیت، فرهنگ، دانش، محیط زیست، حکومت­داری و ده­ها مورد انکشافی دیگر می‌گردد. بنابراین، پرسشی­که مورد توجه قرار می‌گیرد، نقش تحصیلات عالی در تحقق اهداف انکشاف پایدار است.
د لوګر ولایت پر برکي برک ولسوالۍ د سیلابونو د اغېزو ارزونه
Authors: پیروز شریف الله , سهاک کاوون , مجیب مجیب‌الله
Published: January 2025

سیلاب یوه طبیعي پېښه ده چې د ډيرو او دوامداره اورښتونو،  واورو ویلې کېدو او یا د دواړو د یو ځای کېدو په پایله کې رامنځته کېږي او د ګڼو اقتصادي، ټولنیزو، چاپېریالي او روغتیایي ستونزو سبب کېږي. د دې څېړنې موخه په برکي برک ولسوالۍ باندې د سیلابونو د اغېزو ارزونه ده. د څېړنې میتود ساحوي بڼه لري او د پوښتنپاڼې پوسیله چې د ۱۴ معیاري پوښتنو ټولګه ده مالومات د نوموړې ولسوالۍ له ۲۷۰ تنو اوسیدونکو څخه راټول او د Excel پروګرام په وسیله تحلیل او تجزیه شویدي. پایله په ډاګه کوي چې نوموړې ولسوالۍ د لوګر په کچه له مرکز پل علم وروسته دويمه ولسوالۍ ده چې په زیاته اندازه نفوس یې د سیلابونو پر وړاندې زیانمن دی. د دې ولسوالۍ کرنیزې ځمکې، استوګنځایونه ، څاروي، اوسېدونکي او مواصلاتي لاري د سیلابونو پر وړاندې زیاتې اغېزمنې دي او دې پایلي ته په کتو وړاندیز کېږي چې باید دولت د لوګر سیند په حریم کې د خلکو د مداخلې مخه ونیسي، ځنګلونه پرې نه شي او د سیلابونو پر وړاندې د خبرورکونې او  وړاندوینې سیسټمونه رامنځته کړي.
The Role of Language in Identity Formation: A Linguistic Perspective in Education
Authors: Darwin David , Evizariza Evizariza
Published: January 2025

Language plays an important role in the formation of individual and group identities in educational settings. This research aims to understand how language influences student identity from cultural, social, academic and digital perspectives. Using a qualitative approach and case study design, data was collected through in-depth interviews, participatory observation and document analysis. The research subjects included 30 informants from three schools with diverse cultural and social backgrounds. The results show that local languages strengthen students' cultural identity, despite being pressured by the dominance of national and foreign languages due to globalization. In the social context, language functions as a tool for status negotiation and group dynamics. Teaching foreign languages, such as English, increases students' global competence but risks reducing appreciation for local languages. In the digital age, language use on social media reflects students' creative identities but often clashes with formal language norms in schools. This research emphasizes the importance of a balanced language education policy to support global language acquisition while preserving local languages. With this approach, education can help students build an inclusive identity, integrate local values in a global context, and strengthen their cultural connections holistically.
Embedding Character Values in Elementary School : The Key to Future Skills
Authors: Cahya Aulia Ihza , Supriyanto Dede , Iskandar Sofyan
Published: January 2025

Character education in primary schools is a crucial aspect in shaping quality generations, not only academically but also morally. This article aims to explore various dimensions of character education, including theoretical frameworks, successful models, and the challenges and opportunities in its implementation in Indonesia. Integrating character education with 21st-century skills such as creativity, collaboration, and communication is a primary focus, emphasizing the importance of a holistic approach to learning. Additionally, this article offers practical recommendations for linking character education with various teaching methods, including project-based learning, that involve collaboration between schools, parents, and the community. This research also reflects the novelty compared to previous literature, which often remains disconnected from practical contexts. By emphasizing the synergy among stakeholders, it is hoped that an environment supporting student character development can be created, allowing character education to become a key pillar in primary education in Indonesia.
The Future of Inclusive Education: Preparing Students with Special Needs for the World of Work
Authors: Dewi A. Erni Ratna , Nurfaidah Sitti
Published: January 2025

Inclusive education is an important issue in ensuring equal access to education for individuals with special needs around the world. Despite its implementation in various countries, challenges such as skills gaps, lack of assistive technology, and social stigma still hinder the integration of students with special needs into the workforce. This research aims to explore these issues and find solutions that can support the development of inclusive education that is more oriented towards the needs of the world of work. Using a descriptive qualitative approach, the research involved various stakeholders, including students, teachers, parents, employers and policymakers, to identify challenges and opportunities for collaboration between inclusive education and industry. The results showed the need for curriculum revision, integration of assistive technology and increased collaboration between inclusive schools and the world of work to address the skills gap. In addition, strong regulatory support and adequate investment from the government as well as the private sector are necessary to create an inclusive and equitable work environment for students with special needs
Application of STAR Method in English Language Learning at PAUD Nurnaima Bandung City
Authors: Fauzi Deri Fikri , Handayani Sri
Published: January 2025

This study explores the application of the STAR Method in teaching English at PAUD Nurnaima Kota Bandung using a qualitative approach and a case study design. Over two months, the research involved two lecturers and five students, collecting data from two PAUD Tutors and the Head of School. The results indicate that integrating English language material through various forms of play—such as role play, motor play, and construction play—not only enhances children's engagement but also accelerates their understanding of new vocabulary. Children demonstrated a good ability to recognize basic vocabulary, influenced by their habit of watching English-language videos. The findings also suggest that learning activities involving physical movement are more effective in improving vocabulary retention. Overall, the implementation of the STAR Method successfully created a fun and engaging learning environment, providing valuable insights for educators and practitioners about the importance of collaboration between educators and parents, while also encouraging the development of more innovative teaching methodologies at the PAUD level.
Communication Strategies in Delivering Educational Messages on Song Lyrics “Lamunan” and “Lestari”
Authors: Butsiawan Eka , Roekhan Roekhan , Andajani Kusubakti
Published: January 2025

This research focuses on two songs by Wahyu F. Giri, "Lamunan" and "Lestari," which are popular on various music platforms. The study aims to explore the communication strategies used to convey educational messages in the song lyrics. Employing a pragmatic approach, the research analyzes the lyrics through observation and qualitative methods. The findings reveal that "Lamunan" delivers messages of loyalty, patience, love, and self-reflection, while "Lestari" emphasizes natural beauty, eternal love, loyalty, and tranquility. The communication strategies identified include repetition, audience recognition, factual delivery, and persuasion. These strategies enhance the songs' appeal and effectively impart educational values. Beyond their musicality, the songs teach listeners to appreciate relationships, the beauty of nature, and the pursuit of happiness. This study highlights how music can serve as a medium for education, embedding important values within engaging and emotionally resonant content, making it both enjoyable and meaningful for listeners.