bluuebunny/crossref_metadata_2025 huggingface dataset:
Stichwort Truth Social
Authors: Müller Marcus
Published: December 2024

Nachdem die Social-Media-Accounts des ehemaligen US-Präsidenten Donald Trump aufgrund diverser öffentlicher Provokationen auf Facebook und Twitter gesperrt wurden, kündigte Trump kurz darauf an, sein eigenes Soziales Netzwerk zu gründen. Im Februar 2022 startete er dann mit Truth Social seine eigene Plattform und versprach, exklusiv auf dieser Plattform zu posten. Nun ist Trump mit dem Mutterkonzern von Truth Social namens Trump Media & Technology Group an die Börse gegangen. Investor*innen schätzen den Wert von Truth Social auf über 9 Milliarden Dollar. Als die Aktie an die Börse ging, ist diese stark gestiegen. Zugleich hat die Trump Media & Technology Group im Jahr 2023 3,4 Million Dollar Umsatz und 49 Millionen Dollar Verlust gemacht. Das wirft die Frage auf, ob es sich bei dieser Aktie um eine Meme-Aktie handelt, also eine Aktie, die sich unabhängig von den tatsächlichen Unternehmensleistungen viral verbreitet und so ihr Handelsvolumen steigert. Interessant ist auch die Frage, welche Rolle die App und das Unternehmen bezüglich des US- Wahlkampfes 2024 spielen könnten. Im Prozess gegen Trump, in dem er aufgrund von manipulierten Vermögenswerten angeklagt ist, wurde eine Kaution von über 175 Million US-Dollar hinterlegt. Falls der Vorstand von Trump Media & Technology Group zustimmen würde, könnte Trump die Aktien vor einer sechsmonatigen Haltefrist verkaufen, um so seine Kauti- on von 175 Millionen Dollar zu zahlen. Die Social Media App könnte somit für ihn nicht bloß als Kommunikationskanal, sondern auch als Einnahmequelle relevant werden. Zudem könnte die Aktie nicht bloß aufgrund des echten Unternehmenswertes, sondern auch aufgrund politischer Zustimmung an Wert gewinnen.
#72 - Jugend, Medien, Krieg und Frieden Folge 2: Kinder und Krieg in den Medien mit Michael Gurt vom Flimmo
Authors: Merz Redaktion , Gurt Michael
Published: December 2024

Krieg in den Medien ist für Kinder ein herausforderndes Thema. Warum Kinder trotzdem ein Recht auf Nachrichten haben und wie Eltern und pädagogische Fachkräfte sie unterstützen und begleiten können - darüber reden wir mit Michael Gurt vom Flimmo. Flimmo ist der Elternratgeber für TV, Streaming und YouTube und Michael ist der verantwortliche Redakteur vom Flimmo. Er hat viele gute Tipps für Eltern und Pädagog*innen zum Thema Kinder und Krieg in den Medien.
Zum Flimmo
Zu unserem aktuellen Heft - Jugend, Medien, Krieg und Frieden
Heritage Branding and The Value of Nostalgia
Authors: Benedikta Clara , Ekomadyo Agus S. , Viana Anita
Published: December 2024

Coffee is embedded in everyday life as a tradition or ritual within individuals or social communities. Coffee shapes social interactions and cultural practices. Kopi Toko Djawa Pasar Cihapit evokes memories through its spatial dimension. The existence of Kopi Toko Djawa Cihapit gives a nostalgic impression because of its location. Apart from that, the impression of nostalgia from an architectural perspective is also reflected in the interior, which presents a “heritage” atmosphere and strengthens the visitor’s experience in interpreting heritage values in the spatial dimension. The contribution that will be conveyed through this article is a deeper understanding of nostalgia in the form of memory and architecture through coffee in traditional markets, as well as highlighting how this influences community to its dynamics and local identity. This article explores nostalgia in memory and architecture through coffee in conventional markets. The article examines coffee’s cultural and historical significance, using ethnographic methods and interviews to reveal the coffee heritage at Kopi Toko Djawa Cihapit. This research enriches understanding of cultural nuances and underscores the importance of preserving coffee heritage in an architectural context. Qualitative data from the literature, field observations, and interviews with the first barista at Kopi Toko Djawa Cihapit underlie this research.
Assessing the relationship between organizational culture and strategic decision-making through the mediating effect of the dynamic environment in the Jordanian ICT industry
Authors: A. Abou-Moghli Azzam
Published: December 2024

The need for organizations to remain flexible is crucial. This study aims to assess the way organizational culture, dynamic environments, and strategic choices can be related in the case of the Jordanian ICT industry with emphasis on the mediating effect of the dynamic environment. The paper employed a questionnaire sent to 256 employees from several ICT companies involved in strategic decision-making and planning. The analyses showed that organizational culture significantly affects strategic decision-making, with the dynamic environment serving as an important mediator. More precisely, it explained 50.6% of the variance in decision-making (R² = 0.506) and 52.2% of the variance in perceptions about the dynamic environment (R² = 0.522). Thus, consistency (p = 0.007) and adaptability (p = 0.006) emerged as critical cultural dimensions that enhance effective strategic decision-making. Additionally, the prominent effect of the dynamic environment on decision-making was identified (p = 0.000). Therefore, Jordan’s ICT companies can enhance their strategic decision-making and gain a competitive advantage in a sustainable manner by focusing on organizational culture with priorities on consistency and adaptability. This kind of culture ensures better alignment with strategies and quick responses to market or technological changes, contributing to long-term business sustainability.
Acknowledgment Acknowledgments are expressed to Middle East University, Amman, Jordan, for the financial support to cover this article’s publishing fee.
Building Customer and Product Networks with Cosine Similarity in Graph Analytics for Deep Customer Insight
Authors: Albone Aan
Published: December 2024

The goal of social networks is to establish a link that facilitates information sharing and product recommendations between users. For the purpose of comprehending and evaluating links, relationships, and networks, graph theory is indispensable. Our customer network allows us to engage current customers with more products from similar customers and recommend products from one customer to another that are connected by a cosine similarity to the 70% above. If the price of a product is higher than that of comparable products, we can observe the demand for that product in the product network.
IMPORTÂNCIA DOS ENSAIOS FÍSICO-QUÍMICOS NO CONTROLE DE QUALIDADE DE VACINAS
Authors: P. Blanco Maria , Barata Silva Cristiane , A. Vicentini Neto Santos , M. Catarino Lara , de Lima Leitão Ozeias , P. Figuerêdo Elizabete , H. M. Neves Mateus , C. Jacob Silvana , M. G. dos Santos Lisia
Published: December 2024

IMPORTANCE OF PHYSICAL-CHEMICAL TESTS IN VACCINE QUALITY CONTROL. The National Immunization Program (NIP), established in 1973, is recognized nationally and internationally as one of the largest vaccination programs in the world, integrated into the Unified Health System (SUS). Over the years, the NIP has faced challenges in vaccine quality control, leading to significant evolution, especially since 1983 when the National Institute of Quality Control in Health (INCQS) centralized this control. INCQS conducts biological, microbiological, and physicochemical assays, such as pH, appearance, aluminum content, and thiomersal, the latter present in multidose vaccines as a preservative. Retrospective analysis of physicochemical assays reveals variations in analysis quantities, often correlated with specific vaccination campaigns. The introduction of new vaccines in the NIP, such as the pentavalent and inactivated polio vaccines, impacted quality control. Regarding the pH and appearance of vaccines, assays demonstrate improvements over time, including the adoption of more sensitive and specific techniques. The implementation of visual inspection aspect analysis as a preventive measure after occurrences of unsatisfactory lots underscores the commitment to vaccine safety. Public laboratories, like INCQS, play a crucial role in this process, ensuring the safety of immunobiological for the entire Brazilian population. The current challenge lies in the need to keep up with technological advancements to maintain vaccine quality.
Higenamine Detection and Metabolism Study Using High-Performance Liquid Chromatography Coupled to AgIII-Luminol Chemiluminescence
Authors: Wang Haoran , Sha Hanyu , Liu Mengying , Shi Hongmei , Ma Li
Published: December 2024

Herein, we developed a sensitive, selective, efficient, and low-cost method for higenamine (HG)
detection. This method employs high-performance liquid chromatography with a chemiluminescence
detector (HPLC-CL) coupled with an AgIII-luminol system. Lotus plumule and human urine samples
were purified using a mixed weak cation exchange column (PWCX) solid-phase extraction
cartridge, and a C18 column was employed for chromatographic separation using an aqueous
solution of acetonitrile and 0.1% formic acid as the mobile phase. Under optimal conditions, the
chemiluminescence (CL) signal decreased linearly with the logarithm of the concentration of HG
in the range of 5-800 ng mL-1
. The limit of detection (LOD) and limit of quantification (LOQ) of
HG in the urine sample were 0.41 and 1.35 ng mL-1, respectively. The average recovery of HG in
the urine and lotus plumule samples at three levels ranged from 80.02 to 110.40% with a relative
standard deviation of less than 10%. Furthermore, we proposed a mechanism for CL signal reduction
in the system. Finally, the urinary pharmacokinetics of HG in humans were studied to provide
valuable information and reference for athletes on medication or diet during events.
Evaluation of the effects of climatic variabilities on future hydrological scenarios: application to a coastal basin in Central Chile
Authors: Cortés Gonzalez Alejandra Camila , Alcayaga Hernán , Escanilla-Minchel Rossana , Aguayo Mauricio , Aguayo Miguel , Orellana Camila
Published: December 2024

Evaluating the impacts of climate change on coastal basins with a Mediterranean climate represents a significant challenge concerning water security. Consequently, an assessment was conducted on the effects of climate change on hydrological components in a basin within the Coastal Mountain Range of Central Chile. The hydrological model SWAT+ was used, forced by two Shared Socioeconomic Pathways (SSP2-4.5 and SSP5-8.5), incorporating a downscaling process and analyzing both extreme and non-extreme events. Climate projections were made for the following three periods: near (2015–2030), middle (2015–2060), and distant (2015–2100) future. Results indicate a consistent rise in average temperatures across all periods, coupled with decreased precipitation for most of the year. Particularly in the distant future, austral summer stands out as the most impacted season, with projections showing a substantial decrease in precipitation (27 and 54% for SSP2-4.5 and SSP5-8.5, respectively), accompanied by significant increases in both maximum and minimum temperatures. Moreover, the streamflow is anticipated to decline considerably in the austral autumn (−8 and −83% for SSP2-4.5 and SSP5-8.5, respectively). Additionally, as consequences of climate change an increase in droughts (during the dry season) and flooding problems (during the wet season) are expected in the basin, increasing the risk for both extremes.
Study on the ecosystem service value and inter-basin ecological compensation between provinces in China
Authors: Zhao Gaolei , Tian Shimin , Chen Rongxu , Cao Yongtao , Chang Jingyi , Wang Wanwan , Zhang Yang , Wang Xin
Published: December 2024

Land-use/land-cover change (LUCC) in China's seven major basins (SMBs) had a significant impact on the ecosystems, resulting in increasingly prominent contradictions between ecological protection and economic benefits in provinces located upstream and downstream. Therefore, it is urgent to establish inter-basin ecological compensation (EC) mechanisms between provinces in the SMB. Based on five periods of LUCC from 1980 to 2020, the equivalent factor method was applied to evaluate the ecosystem service value (ESV) of the LUCC, and ecological compensation priority sequence (ECPS), horizontal EC (HEC), and vertical EC (VEC) were determined. We found that: (1) The total ESV fell from 11,522 billion yuan (BY) in 1980 to 11,375 BY in 2020. (2) The elasticity index indicated that 1% of LUCC in the SMB resulted in a change of 0.34% in ESV. (3) The province with the highest ECPS was Xizang, with higher ECPS in the SMB southwest and northeast regions. (4) The total VEC was 357.5 BY, with Songhua River Basin and Inner Mongolia having the highest VEC of 134.13 and 97.13 BY, respectively. (5) The total HEC was 103.78 BY. The maximum HEC in the Songhua River Basin was 31.12 BY. Heilongjiang undertook the highest HEC, 31.09 BY.
CRIMES AMBIENTAIS COMETIDOS POR PESSOAS FÍSICAS E DEVIDO PROCESSO NO DIREITO BRASILEIRO
Authors: Alves de Souza Wilson , Trajano de Almeida Silva Tagore , Mota Alves de Souza Valnei
Published: December 2024

Este artigo tem por objeto responder ao problema de saber, em matéria de devido processo penal, ínsitas aí as garantias penais (substanciais e processuais), qual o papel do juiz ao processar e julgar crimes ambientais, em caso de dúvida e outras situações processuais. Para tanto, se defende a tese de que o papel do juiz não se altera, à luz da necessidade de efetivar as garantias penais e processuais penais, pelo fato de estar julgando crimes ambientais.
RESPONSABILIDADE CIVIL DA ADMNISTRAÇÃO PÚBLICA MUNICIPAL PELA VIOLAÇÃO DE DADOS PESSOAIS SENSÍVEIS:
Authors: Franzolin Claudio José , Carmo Letícia Pardo Rodrigues do
Published: December 2024

O artigo explora a intersecção entre responsabilidade civil, cidades inteligentes e a proteção de dados pessoais sensíveis, com ênfase na proteção da saúde. Trata-se de estudo de objetivo exploratório, que coteja a literatura analisada com previsões legais a partir do diálogo das fontes (Constituição Federal, Lei Geral de Proteção de Dados, Código Civil) e, também, aponta decisões judiciais, merecendo destaque a do Supremo Tribunal Federal (STF). Apresenta-se, inicialmente, a interface da saúde de cidades inteligentes. Após, são abordadas diferentes nuances do dever de proteção dos dados pessoais sensíveis dos cidadãos em matéria de saúde e, em sequência, expõem-se aspectos da responsabilidade civil do Município em caso de violação desses dados, sem excluir uma abordagem acerca das limitações orçamentárias municipais para investimento em tecnologia e segurança da informação. Ao final, ressalta-se a necessidade de preparo da comunidade jurídica e dos órgãos competentes para lidar com proteção de dados pessoais sensíveis de saúde dos indivíduos, incluindo a necessidade de despertar uma cultura de dados dos cidadãos.
Resíduos de antiparasitários e agrotóxicos em leite bovino no rio grande do norte
Authors:   , Moreira Josué de Oliveira
Published: December 2024

O leite é uma das vias de eliminação de resíduos de antiparasitários e agrotóxicos que podem afetar a saúde dos consumidores. Sendo assim, objetivou-se verificar a presença de resíduos de antiparasitários e agrotóxicos em leite bovino no Rio Grande do Norte. Foram coletadas 35 amostras de leite, 15 pasteurizados comercializadas formalmente e 20 in natura, comercializadas informalmente para análises de resíduos. Foram utilizadas a Cromatografia Líquida acoplada à Espectrometria de Massas (LC-MS/MS) para detecção de resíduos de antiparasitários e Cromatografia Gasosa acoplada à Espectrometria de Massas (GC-MS/MS) para detecção de resíduos de agrotóxicos. Observou-se ausência de resíduos de antiparasitários nas 35 amostras analisadas. Em relação a determinação de agrotóxicos, as 23 amostras analisadas foram consideradas satisfatórias, abaixo do Limite Máximo de Resíduo (LMR). Foram detectados e quantificados resíduos de agrotóxicos em cinco amostras de leite (22%), três pasteurizado (60%) e duas (40%) in natura com sete (6,6%) compostos químicos. Foi detectada a presença de resíduos de agrotóxicos proibidos no leite como flusilazol, penconasol e tebufempirade, o que indica um alerta em relação à qualidade do produto e a saúde dos consumidores, bem como a necessidade de um maior controle na entrada e comercialização destes produtos no Brasil
Produção de milho verde, seco e para silagem sob doses de nitrogênio fertirrigadas em duas safras de cultivo no semiárido brasileiro
Authors:   , Souza Ênio Gomes Flôr
Published: December 2024

Os agricultores do semiárido brasileiro têm cultivado o milho irrigado, visando, principalmente, à comercialização de espigas verdes e silagem. Entretanto, o cultivo irrigado para grãos secos tem questionamentos quanto aos custos e competitividade de preço frente ao produto não irrigado, oriundo de outras regiões. Nos últimos anos, o uso de fitas gotejadoras e fertirrigação tem se disseminado entre os produtores de milho da região. O nitrogênio (N) é o nutriente mais exigido pelo milho, em que doses crescentes podem incrementar a produtividade da lavoura. Neste sentido, objetivou-se determinar a dose de N via fertirrigação, que proporciona a máxima produção econômica de milho para espigas verdes, silagem e grãos secos, em duas safras agrícolas (verão e inverno), no município de Canindé de São Francisco, Estado de Sergipe, semiárido brasileiro. O delineamento experimental foi em blocos casualizados, com quatro repetições. Em ambas as safras, os tratamentos consistiram em quatro doses de N (0; 80; 160 e 240 kg ha-1), na forma de ureia. No milho híbrido Bt Feroz, quando verde, foram avaliados: teor de N na folha diagnóstica, número e massa de espigas (total e comercializável). No milho destinado à silagem: produtividade de massas fresca e seca da parte aérea. Para grãos secos: alturas da planta e de inserção da espiga, diâmetro do colmo, massa de 100 grãos e produtividade de grãos. Para todos os produtos, foram levantados os custos totais de produção, rendas bruta e líquida, taxa de retorno e índice lucratividade para cada dose de N e safra agrícola. Análises conjuntas foram realizadas para as características com homogeneidade de variâncias entre as safras. Para milho verde, os maiores números de espigas comercializáveis foram alcançados com 152,52 kg ha-1 de N no verão (41.183,84 espigas ha-1) e 190,31 kg ha-1 de N no inverno (53.291,25 espigas ha-1). A renda líquida atingiu valores máximos de R$ 13.473,50 ha-1 (verão) e R$ 18.266,30 ha-1 (inverno), quando aplicadas fertirrigações com 146,58 e 185,83 kg ha-1 de N, respectivamente. Na safra de verão do milho para silagem, a produtividade de massa fresca (26,92 t ha-1) e a renda líquida (R$ 4.318,94 ha-1) foram máximas quando as plantas são fertirrigadas com 87,62 e 71,14 kg ha-1 de N, respectivamente. No inverno, a produtividade de massa fresca (38,14 t ha-1) e a renda líquida (R$ 8.322,79 ha-1) do milho para silagem aumentam até a dose de 240 kg ha-1 de N. Independente das safras, a produtividade de grãos secos (5.441,03 kg ha-1) foi máxima quando o milho foi fertirrigado com a dose de 104,05 kg ha-1 de N. As maiores rendas líquidas de grãos secos foram observadas nas doses de 80 kg ha-1 de N no verão (R$ 1.190,78 ha-1) e 160 kg ha-1 de N no inverno (R$ 2.757,54 ha-1). A safra de inverno foi mais favorável à produção econômica de espigas verdes, silagem e grãos secos
Functional assessment of major salivary glands using scintigraphy
Authors: Luciana Munhoz  , Plauto Christopher Aranha Watanabe  , Christyan Hiroshi IIda  , Emiko Saito Arita
Published: December 2024

To demonstrate a methodology of scintigraphy imaging interpretation considering pixel intensity values in groups of patients presenting lupus erythematosus, Sjögren’s Syndrome (SS), SS associated to systemic lupus erythematosus, parotiditis, drug-induced sialorrhea and salivary glands disease-free. Material and methods: A total of 36 salivary gland scintigraphy images that were from patients with lupus erythematosus, SS, SS combined lupus, parotiditis, and drug-induced sialorrhea were assessed. The pixel intensity of the scintigrams was also evaluated using the standardized grayscale at 8 bits, Images were analyzed under a region of interest (ROI) of 2 cm2 at maximum uptake using ImageJ. Results: Significant differences between the groups were obtained both for parotid (p=0.026) and submandibular glands (p=0.0952). Statistical significant differences were observed in post-hoc tests between Lupus combined with SS patients, for parotid and submandibular glands, when compared to normal group (p=0.04 and p=0.03 respectively). Pixel values were higher for Lupus combined with SS patients, representing a lower uptake. Conclusion: The pixel intensity assessment was able to differentiate and point to lower salivary flow rates for the systemic lupus erythematosus combined with SS patients when compared to other disorders affecting the salivary gland function.
Comparative analysis of the effectiveness of instrumentation with manual stainless steel and NiTi files in the endodontic treatment
Authors: Agatha Lara Santana Prudencio  , Letycia Accioly Simões Coelho  , Maurilio Zandona  , Lucas José dos Santos Antoniassi  , Heitor Garcia Perini  , Ana Victória Lourenço Pontes França  , Bruno da Silva Rocha  , João Pedro Gasparin Tadano
Published: December 2024

The aim of this study was to assess the effectiveness in instrumentation and the main differences between the manual systems K and M. Material and methods: Forty Type IV Vertucci standardized lower molars, considering the degree of curvature, were divided into 2 groups (n=10): M Files and K-File Files. After biomechanical preparation, the teeth were filled using the Tagger Hybrid technique. Digital radiographs were taken in the buccolingual and mesiodistal directions, and the quality of the filling was determined by three calibrated and blinded evaluators using a 4-point scoring system. The instrument fracture index was also recorded. The obtained data were subjected to Mann-Whitney tests (p<0.05). Results: In the analysis conducted by experienced professionals, a higher radiographic quality of obturation was observed in the M file group compared to the K-file group (p<0.05). Regarding the perception of undergraduate students regarding the difficulty of procedures, a greater difficulty was observed in preparing molars with K-Files compared to M Files (p<0.05). A higher percentage of fractured K-Files was observed compared to M Files. Conclusion: M Files provided less difficulty in preparing molars for undergraduate students, had a lower incidence of fracture, and favored better radiographic quality of obturation.
Enhancing Renal Autophagy via Yangshen Paidu Decoction:
AMPK/mTOR Pathway Modulation in Chronic Renal Failure Management
Authors: Tang Hao , Tao Qi , Li Yifan , Bai Xiaohui , Lv Dan , Wang Fang , Pan Ronghua , Zhao Yanmei
Published: December 2024

Objective:

Chronic Renal Failure (CRF) refers to the gradual decline in renal function
caused by various chronic kidney diseases, eventually leading to end-stage renal failure. Yangshen
Paidu Decoction (YPD) is a Traditional Chinese medicine (TCM) formula utilized in CRF treatment.
This work has analyzed the effects of YPD on CRF and the specific mechanism.

Methods:

Network pharmacology was performed to screen effective components and targets of
YPD, from which key targets and signaling pathways contributing the most to the treatment effects
on CRF were determined. Subsequently, we validated the therapeutic role of YPD and the underlying
pathological mechanisms using the 5/6-nephrectomy rat model.

Results:

Network pharmacology analysis showed the mTOR pathway to be a pivotal mechanism
underlying the effectiveness of YPD in CRF treatment. YPD significantly suppressed urine protein
levels, blood urea nitrogen, and serum creatinine in 5/6 nephrectomized rats. Furthermore, YPD remarkably
improved renal pathological injuries. Western blot analysis revealed that YPD enhanced
autophagy and upregulated the expression of nephrin, podocin, beclin1, p-AMPK/AMPK, and p-
ULK1/ULK1, and attenuated the ratios of p-mTOR/mTOR to its downstream protein phosphorylated
eIF4E-binding protein (p-4EBP1). However, these effects were notably reversed by the AMPK inhibitor
compound C.

Conclusion:

Our findings have demonstrated YPD to suppress the mTOR pathway and stimulate
autophagy by modulating AMPK pathways, thereby mitigating podocyte injury and enhancing renal
function. Our study has confirmed autophagy and the AMPK/mTOR pathway as potential targets for
YPD in CRF treatment.
Diabetes Mellitus: Exploring Biomarkers, Complications, and Therapeutic Strategies with a Spotlight on Cyanobacterial Bioactive Compounds - A
Comprehensive Review
Authors: Ahmad Suhail , Akhtar Salman , Kamal Mohammad Amjad , Farooqui Alvina
Published: December 2024

Diabetes, regarded as a prevalent metabolic disorder with multifactorial origins, contributes
to a myriad of global complications. These cumulate an elevated susceptibility to kidney
failure, nerve impairment, blindness, atherosclerosis, heart ailments, and even strokes. Recent
investigations underscore the diverse roles of associated biomarkers in diabetes progression.
Among these are biomarkers for diabetes mellitus such as DPP-4, PPAR-ϒ, SGLT-2, α-amylase,
and α-glucosidase, which are linked to the onset of diabetes and its related problems. As a result
of undesirable adverse consequences linked to extant synthetic antidiabetic medications, research
attention is increasingly directed towards formulating natural antidiabetic drugs, aiming for enhanced
efficacy and reduced complications. Cyanobacteria stand out as a pivotal repository of
natural bioactive metabolites extensively harnessed for pharmaceutical and nutraceutical development.
The potent bioactive compounds sourced from cyanobacteria hold substantial promise,
kindling high expectations in scientific research and presenting vast prospects for drug discovery
and advancement. Some of these bioactive compounds have demonstrated impressive effectiveness,
displaying successful applications across various phases of clinical trials. This review
strives to provide a more precise understanding of diabetes mellitus, encompassing its clinical
manifestation, epidemiological data, complications, and prevailing treatment modalities. The objective
of this review is to contribute researchers and readers an enhanced and accurate understanding
of diabetes mellitus by covering its clinical manifestation, epidemiological evidence,
difficulties, and prevailing therapeutics possibilities.
A Cross-sectional Study on Utilization of Herbal Medications for Anxiety in the Lebanese Population: Usage Patterns and Implications for Harmonizing Mental Health
Authors: Assi Mohammad , Nasser Sahar , Almoussawi Rasha , Hamed Faten , Boukhary Rima , Wattar Jana
Published: December 2024

Background

Anxiety is a highly prevalent mental health issue worldwide, but it is also notably prevalent in Lebanon, where herbal medications and plants are commonly used as complementary or alternative treatments to manage anxiety. Lebanese citizens have undergone various disasters, starting with the economic crisis in 2019, the Beirut port explosion in 2020, and the COVID-19 pandemic, which led to several mental disorders such as anxiety, unipolar depression, and insomnia.

Objective

This study aimed to measure the prevalence and patterns of herbal medications and plant usage for anxiety among the Lebanese population, as well as to explore the factors influencing the decision to use herbal remedies, patient perspectives, and potential implications for mental health support.

Methods

A cross-sectional study was conducted to assess the prevalence of anxiety and the usage of herbal medications and plants among 501 Lebanese outpatients (General Population) aged 20 years and older at Lebanese community pharmacies within Beirut, Mount Lebanon, South, North, Beqaa. Data was collected through personal face-to-face and online structured interviews and surveys, capturing information on herbal medications and plants usage, sources of recommendations, patient perspectives, and perceived efficacy and safety of herbal medications and plants for anxiety.

Results

The study revealed that anxiety was a prevalent medical condition among Lebanese outpatients, with more than 50% reporting anxiety through various symptoms. Furthermore, 27.34% of Lebanese patients had consumed herbal medications, with a notable proportion advising others to use herbal remedies for anxiety. The sources of recommendations for herbal medication usage included mass media, pharmacists, and personal reading/internet. Additionally, a considerable percentage of patients expressed beliefs in the effectiveness and safety of herbal remedies for anxiety while also indicating a lack of awareness regarding potential side effects.

Conclusion

The findings of this study underscore the need for increased awareness, education, and regulatory oversight in Lebanese pharmacists regarding anxiety management using herbal medications and plant-based treatments. This includes public education campaigns, healthcare provider training, and regulatory oversight. Prioritizing patient counseling and further research is essential to assess the efficacy and safety of these treatments within the Lebanese context. This integrative approach, blending traditional practices with evidence-based mental health care, could drive policy changes and improve mental health outcomes in Lebanon.
The Impact of the COVID-19 Pandemic on Lifestyle Behaviors among School Children in Morocco
Authors: Lahyani Youssef , Adarmouch Latifa , Sebbani Majda , El Mouaddib Hicham , Amine Mohamed
Published: December 2024

Introduction

Usually, active children were the first to be affected during the COVID-19 pandemic. This study aimed to describe and assess the impact of the COVID-19 pandemic on the lifestyle behaviors of schoolchildren in Marrakech, Morocco.

Methods

Parents of children from three private voluntary primary schools were asked to complete an online questionnaire. Diet, physical activity, and sleep information were collected from May 11 to June 04, 2020. Changes in lifestyle before and during the COVID-19 pandemic were assessed and analyzed.

Results

There were 124 participants. There were 54% males, the average age was 9.77 ± 1.96 years, and the average BMI was 20.46 ± 6.32 kg. During the COVID-19 pandemic, the following behavioral trends were reported: an increase in the consumption of sugary drinks (53.2%), an increase in the consumption of sweets and chips (50%) (Control no variation of 27.4% and a decrease of 22.5%), increased sedentary time (TV/mobile: 52.4%; video games: 54%), decreased quality of sleep (51.6%) and increased physical game activity (54%).

Conclusion

When encouraging pandemic measures to address COVID-19, it is crucial to consider the invisible effects of these restrictions on the health of childern and to plan for parallel actions to maintain healthy lifestyles and prevent possible impacts on the level of overweight in this vulnerable population.
Segmented Market of Indonesian Coffee Exports to International Market: RFM Approach
Authors:   University of Jember, Rondhi Mohammad , Nugroho Hari ,   University of Jember, Soetriono Soetriono ,   University of Jember, Mori Yasuhiro ,   Rakuno Gakuen University
Published: December 2024

This study aims to determine the characteristics of coffee products in the international market. Data is collected from coffee product export transaction data from 2011-2021, Indonesia Statistic. Export data were selected based on the Harmony system (HS) code of coffee and its derivatives. The analysis method used is RFM (Recency, Frequency, Monetary) Analysis. The results show that there are 12 categories of coffee products exported to 90 countries divided into 9 regions/zones respectively. Coffee export products with the highest interest are arabica WIB (not roasted and not decaffeinated wet-processed Arabica coffee beans) or Robusta OIB (unroasted, with caffeine) coffee. Then the best markets for coffee products exported by Indonesia are the United States, Japan, Malaysia, Germany, Egypt, Georgia, Australia, United Arab Emirate, and Ecuador. The second-best exported coffee product is roasted coffee, with caffeine, unground that being imported Malaysia, China, and New Zealand. The two categories contribute 98% of export volume of Indonesia’s exported coffee and 78% frequency. The study confirms that the choice of coffee and its derivative products in importing countries is influenced by purchase timing, frequency, and funds used. In addition, purchasing factors are also influenced by the characteristics of consumers and processed industries in these importing countries
Aperfeiçoamento da Formação de Bombeiros Através da Realidade Virtual: Perspetivas Sobre Benefícios, Desafios e Integração Tecnológica
Authors: Pinheiro Bruno Miguel , Veiga Pedro Alves da , Branco Paulo Duarte
Published: December 2024

A utilização da realidade virtual (RV) na formação de bombeiros é uma inovação promissora, com o potencial de transformar métodos de treino tradicionais, ao permitir simulações de cenários de alto risco de forma controlada e segura. Este artigo explora os benefícios e os desafios da integração da RV em programas de formação, destacando as suas vantagens no desenvolvimento de competências práticas e na preparação para situações de emergência complexas. O realismo proporcionado pela RV facilita a imersão dos bombeiros em ambientes virtuais onde podem praticar manobras e tomada de decisões sem os riscos inerentes ao uso de fogo real, aumentando a segurança e permitindo a repetição de cenários sem custos adicionais significativos.
 

Contudo, a aplicação da RV enfrenta desafios técnicos e de aceitação. Barreiras como o custo elevado de equipamentos, as dificuldades na criação de simulações completamente realistas, especialmente para replicar fatores como o calor e o fumo, e a resistência de alguns profissionais em adotar tecnologias novas são questões relevantes. Além disso, a necessidade de hardware especializado e a possível ocorrência de desconfortos físicos, como enjoos, indicam a importância de um período de adaptação.
 

Ainda assim, estudos indicam que a RV pode oferecer benefícios significativos, como o feedback imediato e a possibilidade de personalização do treino para responder às necessidades individuais. A integração eficaz da RV requer uma abordagem colaborativa entre corporações de bombeiros e de quem desenvolve a tecnologia para adaptar a inovação às especificidades do treino de emergência. O potencial da RV para elevar o nível de preparação dos bombeiros de forma segura e eficiente aponta para uma aplicação crescente dessa tecnologia na área de segurança pública, destacando a importância de investigações futuras para otimizar o seu uso em cenários reais de emergência.
Pérdida de ecosistemas forestales en dos subcuencas del estado de Oaxaca, México, por el incremento de plantaciones de Agave
Authors: Sandoval García Rufino , Sandoval García Celestino , Sandoval García Carmela , Marroquín Morales Pablo
Published: December 2024

Antecedentes y Objetivos: En las últimas dos décadas, en el estado de Oaxaca, México, se ha incrementado el cambio de uso del suelo para la agricultura, ganadería y el establecimiento de plantaciones de Agave para la producción de mezcal. En la presente investigación se evaluó la pérdida de ecosistemas forestales y de captura de carbono por el incremento de plantaciones de Agave en las subcuencas Río Alto Tehuantepec y Río Tequisistlán en el estado Oaxaca. Métodos: Se realizó un análisis multitemporal, mediante la digitalización a mano alzada de imágenes satelitales de alta resolución (0.28 a 1.5 m/píxel), en el programa QGIS.Resultados clave: La tasa acumulada de cambio de uso del suelo del periodo 1995 al 2022 fue en promedio de 3.07%. La agricultura representó 38% de pérdida de cobertura forestal, mientras que las plantaciones de Agave 62%. En 27 años se han perdido un total de 34,953 ha de ecosistemas forestales en las subcuencas, siendo las más afectadas por su extensión: selva baja caducifolia con 52.91%, seguida del bosque de pino-encino (17.92%) y el bosque de encino (13.20%). La superficie ocupada por la agricultura en 1995 era de 18,704 ha, con una disminución del 29% al 2022 (13,273 ha), mientras que las plantaciones de Agave tuvieron un incremento de más del 400% al pasar de 4889 ha en 1995 a ocupar una extensión de 21,679 ha en el 2022. Conclusiones: La pérdida de cobertura forestal representa una disminución en la captura de carbono, siendo de 3,033,144 Mg C por la selva baja caducifolia, 487,998 Mg C por los bosques de pino-encino y 323,126 Mg C por los bosques de encino. La subcuenca que presentó mayor pérdida fue Río Alto Tehuantepec con el 75%, motivo por el cual se deben priorizar e implementar estrategias de restauración ecológica.
Evaluation of YOLOv8 Algorithm for Vehicle License Plate Detection System in UNY Integrated Parking Lot
Authors: Al Matiin Muhammad Azril Haidar , Arifin Fatchul
Published: December 2024

The YOLOv8 algorithm for the license plate detection system of vehicles entering the integrated parking lot of Universitas Negeri Yogyakarta (UNY) needs to be evaluated because license plate detection is crucial in integrated parking management to improve the security and efficiency of parking lot usage. YOLOv8, as a deep learning-based object detection algorithm, was chosen to improve the accuracy and speed of detection. This research combines the YOLOv8 approach with a dataset specifically designed for the context of UNY parking lots. The testing process was conducted using the required hardware and software to ensure the algorithm's ability to adapt to the real environment. In addition, the performance of YOLOv8 in detecting vehicle license plates under different vehicle license plate conditions, such as black plates or white plates, was also evaluated. The results show that YOLOv8 is able to provide adequate vehicle license plate detection results. This research contributes to give development result of a vehicle license plate detection system for parking management by utilizing the latest object detection technology, as well as providing an overview of the challenges and solutions for implementation of this algorithm in the specific context of UNY parking lots.
Analyzing the Impact of Academic and Financial Factors on the Employment Prosperity of Engineering Graduates: A Case Study from Universitas Negeri Yogyakarta
Authors: Indrihapsari Yuniar , Luthfi Muhammad Irfan , Ardy Satya Adhiyaksa , Shittu Abdul Jaleel Kehinde
Published: December 2024

The rapid technological advancements and evolving job markets present a pressing need to understand how academic experiences shape the career outcomes of engineering graduates. This understanding is crucial for educational institutions aiming to align their curricula with industry demands and for graduates seeking to maximize their career prospects. Notably, the role of financial support, academic performance, and early career experiences in influencing graduate prosperity remains underexplored. This study aims to analyze the correlation between finance support, GPA, study period, job waiting times, salary details, and the prosperity of graduates from the Faculty of Engineering at Universitas Negeri Yogyakarta. The prosperity of graduates is defined as earning wages equal to or exceeding the Indonesian minimum average wage. Using data from a tracer study questionnaire, the research employed logistic regression and correlation analysis to investigate these relationships. The data underwent several stages of filtering, resulting in a refined dataset of 70 records for analysis. This study used SPSS software for statistical analysis, focusing on descriptive statistics, correlation, and logistic regression models. The results highlighted significant predictors of graduate prosperity, including GPA and types of financial support, while illustrating the limited predictive power of early career experiences on long-term earnings. The study also indicated that extended study periods do not necessarily correlate with higher wages. In conclusion, the study underscores the importance of targeted educational strategies and student support systems that are responsive to the dynamics of the job market, enhancing the readiness and prosperity of engineering graduates.
The Implementation of Project-Based Learning (PBL) with ADDIE Model to Improve Students' Creative Thinking Ability
Authors: Wahyudin Wahyudin , Qobus Muhammad Shofwan , Fatimah Nusuki Syariati , Riza Lala Septem , Adedokun-Shittu Nafisat Afolake
Published: December 2024

Creative thinking ability is one of the thinking concepts used to find ideas that people are starting to be interested in. Creative thinking can be used as a relevant tool in building innovation and as a method for building innovation models, one of which is a learning model. The project-based learning model is a solution that influences students' activeness and creativity in learning. The purpose of this research is to apply a project-based learning model that is expected to improve students' creative thinking abilities on creative product and entrepreneurship subjects on the Internet of Things material. The development model used in this research is ADDIE (Analyze, Design, Development, Implementation, Evaluation) with a One Group Pretest-Posttest research design. Based on the research results, there are several conclusions, including the following: 1) Students' creative thinking abilities by implementing the project-based learning model can be seen from the average pretest score of 38.24 and the average posttest score of 70.15. 2) The normalized gain test results obtained a mean of 0.517 with the "Medium" criteria, which means there is a difference in creative thinking abilities after the treatment process. There are four aspects given when giving the TAM questionnaire to students, namely the user's perception of usefulness with a percentage of 86.67%, the user's perception of ease of use with a percentage of 84.71%, attitude towards use with a percentage of 83.53 and attention. With a percentage of 86.27%, and the average obtained for the four aspects was 85.29% in the "Very Good" category.
A Local-level App vs A National-level App: Evaluation of M-Grocery Apps From The UX and The Service Performance Perspective
Authors: Asyari Hasyim , Ulya Devy Alfianur Fathu , Muhammad Katon , Prakoso Indro , Al Hakim Reza Azizul Nasa
Published: December 2024

In Indonesia, the increase in internet users, reaching 215.63 million in 2022-2023, has facilitated the growth of mobile shopping applications like Sayurbox and Beceran, which cater to daily needs such as groceries and fresh food items. Despite receiving high user ratings, these applications face technical issues that could impact user satisfaction and company revenue. This study aims to evaluate the service quality and user experience of the Sayurbox and Beceran applications using the M-S-QUAL and UX Benchmarking methods. The M-S-QUAL method assesses service quality across nine dimensions, while UX Benchmarking evaluates user satisfaction, ease of use, error counts, success rates, and task completion times. The results of UX Benchmarking reveal that Sayurbox has fewer errors and higher user satisfaction compared to Beceran, which has faster loading times but more errors. The M-S-QUAL analysis indicates that both applications have negative gap values in most service attributes, with Sayurbox performing slightly better than Beceran. Sayurbox received a score of -0.25 for the value gap on the M-S-QUAL scale, while Beceran received a score of -0.41 for the value gap.
Diagnosis of the anatomic preconditions of intermittent testicular torsion
Authors: Sablin D. E. , Sizonov V. V. , Kagantsov I. M. , Shamik V. B. , Lukash Yu. V.
Published: December 2024

Introduction. In a series of studies, patients with intermittent testicular torsion (ITT) have a 29% to 50% chance of gonad loss. The «bell clapper» type testicular fixation abnormality is a predisposing factor for TT. In cases of ITT, episodes of hemiscrotal pain attack are not a sufficient reason to scrotal revision, which makes it important to develop imaging techniques to document the presence of anatomical preconditions for ITT.

Objective. To find a methodology beneficial in solving the problem of documenting the anatomical preconditions for ITT.

Materials & methods. To diagnose anatomical preconditions of ITT, we have developed a method of ultrasound. Ultrasound can be used to prove the presence of a “bell clapper» deformity by visualizing the spermatic cord proximal to the testis surrounded by fluid. Fix the testis with a slight traction in a caudal direction while moving the fluid inside the sheaths upward. Place the transducer over the spermatic cord in a horizontal position. The fluid is displaced abnormally high along the spermatic cord within the peritoneal vaginal sheath and surrounds the spermatic cord on all sides, allowing good visualization of the spermatic cord above the testis within the testicular sheaths. If we continue with the bell analogy, the resulting ultrasound picture can be called «bell clapper rod» symptom. A patient with an ultrasound-derived «bell clapper rod» symptom can be diagnosed with a testicular fixation anomaly that creates anatomic conditions for intermittent testicular torsion. The ultrasound arguments obtained allow us to confidently form indications for testicular fixation.

Results. Eight patients were examined according to the described method, all of them showed the symptom of ‘bell clapper rod’, and testicular fixation was recommended. The average age of the patients was 12.4 years. The average time after scrotal pain resolution was 8 hours (from 1 to 18 hours). All eight patients had intraoperative verification of abnormal testicular fixation of the ‘bell clapper rod’.

Conclusion. A patient with the acute hemiscrotal pain and then its spontaneous disappearance with the ultrasound-derived «bell clapper rod» symptom can be diagnosed with a testicular fixation anomaly that creates anatomic conditions for ITT. Preoperative diagnosis based on ultrasound combined with clinical data transforms the ITT from a diagnosis of exclusion to a diagnosis based on proven anatomical preconditions for testicular torsion. The ultrasound arguments obtained allow us to confidently form indications for testicular fixation.
Expression of angiotensin II type 2 receptors and syndecan-1 in prostate cancer
Authors: Chernogubova E. A. , Avetyan A. V. , Chibichyan M. B. , Kogan M. I.
Published: December 2024

Introduction. Prostate cancer (PCa) remains an urgent problem of modern oncological urology due to high morbidity and mortality rates.

Objective. To evaluate the expression of angiotensin II type 2 receptor (AT2-R) and syndecan-1 (CD138) receptors in prostatic intraepithelial neoplasia (PIN) and PCa.

Materials & methods. For the immunohistochemical (IHC) study, the prostate biopsy cores of 20 men was used: 10 men with PIN, 10 men with PCa. Primary antibodies to AT2-R and CD138 antibodies were used for IHC staining, the EnVision FLEX imaging system. Formulation of IHC reactions, interpretation of the results obtained were carried out according to generally accepted rules.

Results. The results of the study showed that AT2-R deficiency increases in the range of PIN-3 – PCa. Mild AT2-R expression or its absence was noted in tumor cells with PCa, while the AT2-R localisation was nuclear. In PIN-3, the expression of syndecan-1 was localised on the membrane of basal cells and the basolateral side of secretory epithelial cells, without expression in the adjacent stroma, while the expression level of syndecan-1 always remained high. In PCa, the membrane expression of syndecan-1 was preserved. With a decrease or absence of AT2-R nuclear expression in PCa tissue with an increase in ISUP, the expression level of syndecan-1 decreased.

Conclusion. Simultaneous decrease in the expression levels of AT2-R and syndecan-1 in PCa has been demonstrated for the first time. A comprehensive determination of the expression levels of AT2-R and syndecan-1 seems to be promising for the development of diagnostic and prognostic markers of PCa initiation and development.