bluuebunny/crossref_metadata_2025 huggingface dataset:
Integration of microbiome and Koch’s postulates to reveal multiple bacterial pathogens of whitish muscle syndrome in mud crab, Scylla paramamosain
Authors: Hou Dongwei , Lian Taixin , Guo Guangyu , Gong Han , Wu Chengcheng , Han Peiyun , Weng Shaoping , He Jianguo
Published: July 2023

Background

For more than a century, the Koch’s postulates have been the golden rule for determining the causative agents in diseases. However, in cases of multiple pathogens-one disease, in which different pathogens can cause the same disease, the selection of microorganisms that regress infection is hard when Koch’s postulates are applied. Microbiome approaches can obtain relatively complete information about disease-related microorganisms and can guide the selection of target microorganisms for regression infection. In the present study, whitish muscle syndrome (WMS) of Scylla paramamosain, which has typical symptoms with whitish muscle and blackened hemolymph was used as an example to establish a new research strategy that integrates microbiome approaches and Koch’s postulates to determinate causative agents of multiple pathogens-one disease.

Results

Microbiome results revealed that Aeromonas, Acinetobacter, Shewanella, Chryseomicrobium, Exiguobacterium, Vibrio and Flavobacterium, and Kurtzmaniella in hemolymph were bacterial and fungal indicators for WMS. A total of 23 bacteria and 14 fungi were isolated from hemolymph and muscle tissues, and among the bacteria, Shewanella chilikensis, S. xiamenensis, Vibrio alginolyticus, S. putrefaciens, V. fluvialis, and V. parahaemolyticus were present in hemolymph and/or muscle tissues in each WMS crab, and the last three species were also present in three Healthy crabs. The target bacteria and fungi were further screened to regression infections based on two criteria: whether they belonged to the indicator genera for WMS, whether they were isolated from both hemolymph and muscle tissues in most WMS crabs. Only S. chilikensis, S. putrefaciens, S. xiamenensis, V. alginolyticus, V. fluvialis, and V. parahaemolyticus met both two criteria. The six bacteria that met both two criteria and six fungi and another bacterium that unmatched any of two criteria were used to perform regression infection experiments based on Koch’s postulates. S. chilikensis, S. putrefaciens, S. xiamenensis, V. alginolyticus, V. fluvialis, and V. parahaemolyticus met both two criteria, and the results indicate that they cause WMS in crabs independently.

Conclusions

This study fully demonstrated that our research strategy that integrates the microbiome and Koch’s postulates can maximize the ability to catch pathogens in one net for the situation of multiple pathogens-one disease.
Investigating the dark-side of the genome: a barrier to human disease variant discovery?
Authors: Ryan Niamh M. , Corvin Aiden
Published: July 2023

The human genome contains regions that cannot be adequately assembled or aligned using next generation short-read sequencing technologies. More than 2500 genes are known contain such ‘dark’ regions. In this study, we investigate the negative consequences of dark regions on gene discovery across a range of disease and study types, showing that dark regions are likely preventing researchers from identifying genetic variants relevant to human disease.
Percutaneous tracheostomy in patients with COVID-19 infection and acute respiratory failure
Authors: Singh Tushi , Sarwar Hasham , Hurtado Andres , Islam Ebtesam
Published: July 2023

Background: Tracheostomy is often performed in patients who need prolonged intubation. COVID -19 brought unforeseen challenges, thus altering previously established norms. In this study, the outcomes of the patients undergoing tracheostomy for respiratory failure due to COVID -19 were studied.
Methods: This is a single center retrospective observational cohort study of patients who underwent percutaneous tracheostomies between March 1, 2020, and September 30, 2021, due to respiratory failure secondary to COVID-19. Inclusion criteria included performance of percutaneous tracheostomies on patients with confirmed diagnosis of COVID-19. Exclusion criteria included patients undergoing surgical tracheostomies, extubation prior to the performance of a tracheotomy, and death prior to the performance of the tracheotomy.
Results: The study included 49 patients after reviewing the records of 101 patients who underwent tracheostomies during the study period. The average age of the population was 59 ± 11years; 33 patients (67%) were men. The median Sequential Organ Failure Assessment (SOFA) score on admission was 2.  The median duration of mechanical ventilation prior to tracheostomy was 18 days; the median positive end expiratory pressure was 10 cm H2O and the median fraction of inspired oxygen (FiO2) was 0.45. Two patients died during the procedure, one secondary to cardiac arrest and one secondary to bleeding. Eighteen patients (38%) died after the procedure during hospitalization; the median length of mechanical ventilation for all patients was 32.5 days.  Eleven patients (22%) were eventually decannulated. Twenty patients (40%) were discharged to rehabilitation, and nine patients (18%) were discharged home. Eighteen patients (36%) were alive at the end of 90 days. Twelve patients (26%) were lost to follow up after discharge from the hospital. At the time of the tracheostomy, 16 patients (32%) had moderate ARDS as per the Berlin definition, and 12 (24%) had severe ARDS.
Conclusion: Tracheostomy is an important therapeutic intervention in critically ill patients requiring mechanical ventilation.  The COVID-19 pandemic raised important concerns and uncertainties about the management of these patients and the safety of healthcare workers.  In this study, 29 patients (59%) undergoing tracheostomies recovered enough to be discharged to rehabilitation or to their homes.  The risks to patients and to healthcare workers seem reasonable, but the optimal timing is uncertain and is best tailored to each patient based on his/her clinical status and prognosis.
 
Keywords: COVID-19, tracheostomy, mechanical ventilation, acute respiratory failure
Healthcare and Behavior Changes for Adults With Down Syndrome 1-Year Into COVID-19
Authors: Rubenstein Eric , Kyprianou Nichole , Kumar Prisha Sujin , Kriova Anna-Mariya , Sokoloff Alexis , Hillerstrom Hampus , Hendrix James
Published: July 2023

Individuals with Down syndrome (DS) have been disproportionately harmed by the COVID-19 pandemic and may have been more likely to have sacrificed opportunity and activity to avoid potential exposures. Our objective was to describe the experience one to one and half years into the COVID-19 pandemic for adults with DS, as reported by their caregivers in an online survey conducted between April 2021 and September of 2021. In our sample of 438 adults with DS, caregivers reported that adults with DS lost activities, struggled with employment, had negative behavioral changes, lost skills, and developed more mental health conditions. For adults with DS, one in five caregivers reported less healthcare usage, one in four reported delayed routine care, and 86.5% reported lost activities. As the pandemic continues, targeted support for adults with DS is needed to prevent further skill loss and mental health conditions.
Optical bistability in a heterodimer composed of a quantum dot and a metallic nanoshell
Authors: Zhao Wen-Hao , He Meng-Dong , Long Lin-Wen , Peng YU-Xiang , Xiao Si , Li Jian-Bo , Chen Li-Qun
Published: July 2023

We theoretically explore the conditions for generating optical bistability (OB) in a heterodimer comprised of a semiconductor quantum dot (SQD) and a metallic nanoshell (MNS). The MNS is made of a metallic nanosphere as a core and a dielectric material as a shell. For the specific hybrid system considered, the bistable effect appears only if the frequency of the pump field is equal to (or slightly less than) the exciton frequency for a proper shell thickness. Bistability phase diagrams, when plotted, show that the dipole-induced bistable region can be greatly broadened by changing the shell thickness of the MNS in a strong exciton-plasmon coupling regime. In particular, we demonstrate that the multipole polarization not only narrows the bistable zone but also enlarges the corresponding thresholds for a given intermediate scaled pumping intensity. On the other hand, when the SQD couples strongly with the MNS, the multipole polarization can also significantly broaden the bistable region and induce a great suppression of the FWM (four-wave mixing) signal for a fixed shell thickness. These interesting findings offer a fresh understanding of the bistability conditions in an SQD/MNS heterodimer, and may be useful in the fabrication of high-performance and low-threshold optical bistable nanodevices.
Hybrid graphene - silver nanoantenna to control THz emission from polar quantum systems
Authors: Izadshenas Saeid , Gładysz Piotr , Słowik Karolina
Published: July 2023

Fluorescent light emission from atomic quantum systems routinely occurs at the illumination frequency. If the system is polar, an additional fluorescence peak appears at a much lower Rabi frequency, which scales with the illumination field amplitude. This opens the possibility of spectrally controlling the emission, promising tunable coherent radiation sources. However, typically the emission occurs in the MHz to GHz regimes, and its intensity from a single quantum system is relatively low. Here, we propose a hybrid nanoantenna combining noble-metal and graphene elements, exploited for an unusual goal: The silver elements spectrally tune the emission frequency of the molecule and shift it to the THz band, where novel sources of coherent radiation are still desired. Additionally, the graphene elements are used to plasmonically enhance the emission intensity. Their tunability allows for adjustment of the operational frequencies of the device to the illumination conditions and to counteract the fluctuations related to the field modulations in space. All these features are discussed based on the real-life example of a polar molecule of barium monofluoride (BaF).
In silico designing and immunoinformatics analysis of a novel peptide vaccine against metallo-beta-lactamase (VIM and IMP) variants
Authors: Motamedi Hamid , Alvandi Amirhoushang , Fathollahi Matin , Ari Marzie Mahdizade , Moradi Sajad , Moradi Jale , Abiri Ramin
Published: July 2023

The rapid spread of acquired metallo-beta-lactamases (MBLs) among gram negative pathogens is becoming a global concern. Improper use of broad-spectrum antibiotics can trigger the colonization and spread of resistant strains which lead to increased mortality and significant economic loss. In the present study, diverse immunoinformatic approaches are applied to design a potential epitope-based vaccine against VIM and IMP MBLs. The amino acid sequences of VIM and IMP variants were retrieved from the GenBank database. ABCpred and BCPred online Web servers were used to analyze linear B cell epitopes, while IEDB was used to determine the dominant T cell epitopes. Sequence validation, allergenicity, toxicity and physiochemical analysis were performed using web servers. Seven sequences were identified for linear B cell dominant epitopes and 4 sequences were considered as dominant CD4+ T cell epitopes, and the predicted epitopes were joined by KK and GPGPG linkers. Stabilized multi-epitope protein structure was obtained using molecular dynamics simulation. Molecular docking showed that the designed vaccine exhibited sustainable and strong binding interactions with Toll-like receptor 4 (TLR4). Finally, codon adaptation and in silico cloning studies were performed to design an effective vaccine production strategy. Immune simulation significantly provided high levels of immunoglobulins, T helper cells, T-cytotoxic cells and INF-γ. Even though the introduced vaccine candidate demonstrates a very potent immunogenic potential, but wet-lab validation is required to further assessment of the effectiveness of this proposed vaccine candidate.
Restricted Computations and Parameters in Type-Theory of Acyclic Recursion
Authors: Loukanova Roussanka
Published: July 2023

The paper extends the formal language and the reduction calculus of Moschovakis type-theory of recursion, by adding a restrictor operator on terms with predicative restrictions. Terms with restrictions over memory variables formalise inductive algorithms with generalised, restricted parameters. The extended type-theory of restricted recursion (TTRR) provides computations for algorithmic semantics of mathematical expressions and definite descriptors, in formal and natural languages. The reduction calculi of TTRR provides a mathematical foundation of the work of compilers for reducing recursive programs to iterative ones. The type-theory of acyclic recursion (TTAR) has a special importance to syntax-semantics interfaces in computational grammars.
Applying the PERMA model in employee wellbeing
Authors:   West Pomeranian University of Technology in Szczecin, Poland, Wilczyński Artur , Kołoszycz Ewa ,   West Pomeranian University of Technology in Szczecin, Poland
Published: July 2023

The aim of this study is to define the essence of wellbeing in employee management, and present the functionality of the PERMA model in positive psychology. The first part of the study describes the multidimensionality of the concept of wellbeing and the difficulties in defining it. An important element of the conducted analysis is the presentation of the positive effects of the implementation of wellbeing in organisations, including elements of wellbeing dimensions and activities affecting wellbeing, while the most important part of the article is the diagnosis of the applicability of the PERMA model in the study of employee wellbeing and positive education. Different elements of the model are described and the latest solutions with regards to its improvement are presented. An analysis of the literature showed that a model with four additional dimensions - physical health, mindset, work environment and economic security - may be the most useful for analysing employee wellbeing. The next part of this publication is devoted to the use of the PERMA model in the classification of interventions, where we show that the model not only enables diagnosis of the weaknesses of wellbeing, but even facilitates the assigning of specific interventions. These solutions make it possible to build wellbeing that positively impacts employee behaviour, with the authors indicating discrepancies in the activities undertaken by organisations and the needs of employees with regards to wellbeing. The findings suggest that employees expect activities related to the development of their mental dimension and economic security, not necessarily related to physical health, which are most commonly implemented by organisations.
Preparation and surface acid-base properties of porous cellulose
Authors: Wang Huanfeng , Li Bin , Shi Baoli
Published: July 2023

Porous cellulose beads were prepared by solubilizing cellulose in sodium hydroxide/urea/sulfourea aqueous solution and then solidifying liquid beads in hydrochloric acid. Scanning electron microscopy (SEM) was used to characterize the morphologies of surface, cross section, and wall structures of the porous cellulose beads, which are folded and porous. The surface acid-base properties of porous cellulose beads were characterized in detail by inverse gas chromatography (IGC). The Lewis basic number Kb was found to be 0.854, which is indicative of a Lewis basic polymeric material. With the discussion of the results of SEM and IGC, a conclusion can be drawn that the porous cellulose beads showed a good ability of adsorbing the smoking tar of cigarettes.
Religion in the 21st Century
Authors: Beyer Peter
Published: July 2023

Religion as a category and object of study in (Western) academia has undergone a sequence of upheavals over the last several decades, responding to significant transformations in global society and as a reflection of internal disciplinary developments. This paper focuses on such transformations and developments principally within the disciplines the sociology of religion and religious studies. After summarizing these transformations, it presents three interrelated arguments: a) Both transformations, in the disciplines and in the larger social context, are the latest versions of very long discussion and development that have their roots in the nineteenth-twentieth century foundation of religion as an analytic category, in the imperial/colonial spread and glocal appropriation of the category of religion, and in the “Westphalian” institutional modeling of religion with the modern nationstate. b) The current transformations in the “religious field” are a reflection of a decline in that modeling, yielding further uncertainty about how religion should be conceived. c) The ideas of religion and secularization should not be discarded, but should be contextualized in a broader diversity of categorization that goes beyond the binary modeling of religion/not-religion (or secular). A systems-theoretical approach informs all three arguments.
MASS MORTALITY OF CORALS AND REEF LIVING FEATURES AT CON DAO ARCHIPELAGO (VIETNAM) IN OCTOBER 2005
Authors: Ben Hoang Xuan , Tuan Vo Si , Hoang Phan Kim
Published: July 2023

Con Dao archipelago located in the southeastern waters of Vietnam at 8037’ – 8048’ N and  106032’ - 106045’ E is characterised by diverse terrestrial and marine ecosystems. Coral reefs occupy the area around  1000 ha  with more than 320 hard corals species recorded. A catastrophe causing mass mortally of corals and reef  leaving features occurred in October 2005. Almost coral reefs in the northeastern waters of the archipelago was impacted, indicating mortality of corals ranking from 20% to nearly 100%. The mass mortality is more  serious in reef flats in comparison with that in reef slopes. All hard corals of genera Acropora, Leptoria,  Platygyra, Montipora and Porites died in reef flats meanwhile Galaxea is more resilient to the impact.  Almost non-movable benthic invertebrates also died and density of reef fish decreased seriously on  impacted reefs.The analysis of water samples and the data recorded by the Station of Meteorology and Hydrology at Con  Dao showed the reason of the catastrophe. Water temperature in Con Dao increased with temperature more  than 300C in lots of days during October, especially more than 310C on 11th and  12th October. In the same time, salinity also reduced with value less than 25%o in 7 days. Combination impact of these two factors  were considered as the reason for mass mortality in the event. A hypothesis that fresh water from river  mouths of the Mekong river system was dispersed to the archipelago during this period was recommended for further surveys.
Bundle-move analysis in research article of science and technology: connecting lexical bundles and rhetorical move
Authors: Insani Ina , Roselani Ni Gusti Ayu
Published: July 2023

This research identifies lexical bundles which are connected to move analysis in research article of Science & Technology. The corpus-based analysis was used to acquire lexical bundles qualification of frequency and range. A number of bundles which were listed in the corpus were identified structurally and functionally using taxonomy approach by Biber et al., (2004). Further analysis was conducted to connect lexical bundles expression with rhetorical move. Connecting lexical bundles and move analysis in research articles aims to test whether lexical bundles can be used as move markers in academic discourse. The classification of move in a full-length research articles was adapted from Nwogu (1997). In the various structural and functional forms of bundles which are found in this study bring to the list of lexical bundles which indicate various move. The finding of this research is mainly supporting previous study where some bundles expressions have strong connection to rhetorical move in research article. Other finding shows that lexical bundles expressions could occur in more than one move. However, we found that not all of the bundles could express specific move (e.g. the value of the, the length of the, absorption process of the) and not all move is expressed by lexical bundles (move 8).
SARCOMA GRANULOCÍTICO CUTÂNEO: RELATO DE CASO E REVISÃO BIBLIOGRÁFICA
Authors: ORNELAS ANDRÉ , Laviola Poliana , Oliveira Felipe , Trindade Luciana , Brito Marina , Cruz Lafayette
Published: July 2023

O sarcoma granulocítico (SG) é uma massa tumoral formada por mieloblastos ou células mielóides imaturas que aparece em locais extramedulares, como a pele. Geralmente é secundário à leucemia mielóide aguda. Trata-se de uma condição rara e de difícil diagnóstico, principalmente na ausência de anormalidade hematológica. O presente estudo tem o objetivo de relatar um caso de SG restrito à pele e de apresentar uma revisão integrativa sobre o tema. Trata-se do caso de um paciente masculino de 44 anos, com histórico de lesões cutâneas. No exame físico, mostrava lesões cutâneas exuberantes, na forma de tumorações e nódulos eritemato-purpúricos em cabeça, tronco e membros superiores. Não havia evidências clínico-laboratoriais de doença mieloproliferativa e o estudo imuno-histoquímico foi decisivo para determinação do diagnóstico correto de SG restrito à pele. Na revisão da literatura, foram selecionados 25 artigos, focando nos aspectos epidemiológicos, clinico-dermatológicos e perfil imuno-histoquímico do SG cutâneo. A relevância do estudo está relacionada ao estímulo ao reconhecimento precoce da doença pelos dermatologistas e outros médicos, o que poderá repercutir em tratamento adequado e melhoria na qualidade de vida dos afetados.
ANSIEDADE, ATIVIDADE FÍSICA E SOLIDÃO DE ADULTOS DURANTE A PANDEMIA DA COVID-19
Authors: José da Silva Júnior Hamilton , Ferreira Mendes do Nascimento Paula , Maria Mesquita de Lima Quirino Natália , Oliveira Leonardo Santos
Published: July 2023

As medidas de distanciamento social e as diferentes restrições sanitárias, devido à pandemia da COVID-19, levaram, ainda mais, a uma redução nos níveis de atividade física (AF) das pessoas. Outra consequência documentada é o aumento de casos de ansiedade e outros agravos na saúde mental da população. Portanto, o objetivo deste estudo é investigar os níveis de ansiedade, AF e aspectos do distanciamento social de adultos em função da pandemia da COVID-19. Trata-se de um estudo comparativo associativo, em que 127 participantes responderam um formulário online, composto por três seções: i) Aspectos relacionados à pandemia da COVID-19 (ex.: adesão às diretrizes do distanciamento social, solidão, estado vacinal de COVID-19); ii) Aspectos da AF (ex.: nível de AF pré-pandemia e atual); e iii) Aspectos dos transtornos de ansiedade. Associações ordinais entre AF, ansiedade e solidão foram analisadas pelo coeficiente gama (γ). Os resultados apontaram que a ansiedade guarda relação com a solidão (γ= 0,567; P= 0,005), mas não com os níveis de AF durante a pandemia (γ= −0,03; P= 1,000). Além disso, não foram observadas evidências de associação entre AF e solidão (γ= 0,09; P= 0,587). Conclui-se que a AF não apresentou evidências de associação com níveis reduzidos de ansiedade em adultos de ambos os sexos, durante a pandemia da COVID-19. Contudo, indivíduos que se sentiram mais solitários durante a pandemia, mostraram-se mais propensos a sintomas de ansiedade. A combinação entre redução da AF, níveis elevados de sintomas de ansiedade e de solidão pode ser preocupante para a saúde pública.
Innovative low-cost engineered adsorbents based on eggshell waste for nickel removal from aqueous solutions
Authors: SEGNEANU Adina-Elena , TRUSCA Roxana , CEPAN Claudiu , MIHAILESCU Maria , MUNTEAN Cornelia , HEREA Daniel Dumitru , GROZESCU Ioan , SALIFOGLOU Athanasios
Published: July 2023

In contemporary sustainable economy, innovation is prerequisite to waste recycling into new efficient materials, designed to minimize pollution and conserve non-renewable natural resources. Water pollution is a global problem with health, quality of life, and food safety concerns. Thus, waste conversion into cheap, efficient adsorbent materials with high reusability is a challengein wastewater recycling. In that context, starting from eggshell waste in this study, two new low-cost engineered adsorbents were prepared for the retrieval of nickel from aqueous solutions. Scanning electron microscopy (SEM) results show that, in the first eggshell-zeolite (EZ) adsorbent, the zeolite nanoparticles were loaded in the eggshell pores. The preparation for the second (iron(III) oxide-hydroxide)-eggshell-zeolite (FEZ) adsorbent led to double functionalization of the eggshell base with the zeolite nanoparticles, upon simultaneous loading of the pores of the eggshell and zeolite surface with FeOOH particles. Structural modification of the eggshell led to a significant increase of the specific surface, as confirmed by BET analysis. These features enabled the proposed adsorbents (EZ and FEZ) to remove nickel from aqueous solutions with high performance and adsorption capacities 321.1 mg/g and 287.9 mg/g, respectively. The results indicate that nickel adsorption on EZ and FEZ is a multi-molecular layer, spontaneous, and endothermic process. Concomitantly, desorption results reflect high reusability of these two adsorbents, collectively suggesting the use of waste in the design of new, low-cost, and highly efficient engineered adsorbents for environmental bioremediation
Thermohydraulic Performance Analysis of Tube Heat Exchanger using Dual Side Serrated Insert Tape Having Triangular Wings
Authors: Sharma Sohan Lal , Singh Satyendra , Debbarma Ajoy
Published: July 2023

The thermal performance of heat exchangers can be improved by increasing the rate of heat transfer. Heat transmission and fluid flow characteristics have been improved in this experimental study by adopting a dual-side serrated insert tape with triangular wings. Different geometrical parameters such as wing pitch ratio (P/W), wing width ratio (w/W), wing depth ratio (d/W), serration width ratio (x/W), and perforation index (PI) are considered. The work is performed with various configurations of flow direction such as forward and backward flow with and without alternate axis using various ranges of Reynolds Number (i.e., 10000 ≤ Re ≤ 30000). According to the findings, the forward flow configuration of the insert performs better as compared to the backward flow. But the alternate axis with backward flow configurations and without perforation on the winglet improved thermal performance up to 1.05 times. In the alternate axis with forward flow configuration and with perforation on the winglet, the friction factor is at its lowest value. The Nusselt number and thermal performance factor enhanced up to 1.5 times, and 1.03 as compared to the plain tube.
A plant litter decay experiment unveiled anaerobic lignin decomposition in a rewetted peatland
Authors: Reuter Julia , Reuter Hendrik , Zak Dominik
Published: July 2023

The rewetting of long-term drained peatlands leads to the development of eutrophic shallow lakes, gradually inhabited by reed communities. These shallow lakes are characterized by significant nutrient and methane emissions. To gain a better understanding of the fate of organic compounds derived from decaying Phragmites australis litter in both the aquatic phase and underlying anaerobic soil layers, a decomposition experiment was conducted over a period of approximately 1.6 years. The experiment employed bulk and lignin-derived phenol analysis, as well as Fourier-transform infrared spectroscopy. As anticipated, the highest level of decomposition was observed in the surface water body of the shallow lake, while the non-rooted degraded peat exhibited the lowest decay. The bulk mass loss of plant litter decreased with depth from 55–27% across the four decomposition environments. Analysis using infrared spectroscopy indicated that the decrease in mass loss was primarily driven by the breakdown of carbohydrates, which constitute a significant portion of plant litter. Interestingly, the rooted degraded peat layer exhibited the highest degree of lignin decay. Furthermore, the study revealed a preferential loss of vanillin phenols and an accumulation of p-hydroxyl phenols. These findings suggest that the increased methane emissions in rewetted fens may be partially attributed to the demethoxylation of vanillin phenols and the subsequent formation of p-hydroxyl phenols. In conclusion, this study provides valuable insights into anaerobic lignin decomposition of plant litter and sheds light on potential mechanisms underlying methane emissions in rewetted peatlands.
Foscarnet eyedrops for the treatment of refractory herpetic keratitis
Authors: Awh Caroline C. , Knapp Austen N. , Goshe Jeffrey M. , See Craig W. , Lowder Careen Y.
Published: July 2023

Purpose
The purpose of this case series is to describe the clinical course of patients receiving foscarnet eyedrops for the treatment of refractory herpetic keratitis.
Observations:
Six patients diagnosed with herpetic keratitis were treated with foscarnet 24 mg/mL (2.4%) eyedrops with resulting improvement in keratitis.
Conclusion
Topical foscarnet may be a safe and effective treatment for herpetic keratitis in conjunction with, or as an alternative to, conventional antiviral therapy. This is an off-label use of foscarnet.
Factors Influencing Preferences of Patients With Rheumatic Diseases Regarding Telehealth Channels for Support With Medication Use: Qualitative Study (Preprint)
Authors: Haegens Lex L , Huiskes Victor J B , van der Ven Jeffrey , van den Bemt Bart J F , Bekker Charlotte L
Published: July 2023

BACKGROUND

Patients with rheumatic diseases are known to experience drug-related problems at various times during their treatment. As these problems can negatively influence patients’ health, they should be prevented or resolved as soon as possible, for which patients might benefit from additional support. Telehealth has the potential to continuously provide information and offers the possibility to easily contact a health care provider in order to support patients with medication use. Knowledge of factors influencing the patient’s preference for telehealth channels can improve the actual use of telehealth channels.

OBJECTIVE

This study aims to identify factors that influence the preferences of patients with rheumatic diseases regarding telehealth channels for support with medication use.

METHODS

A qualitative study with face-to-face interviews was performed among patients with an inflammatory rheumatic disease in the Netherlands. A total of 4 telehealth channels were used: a frequently asked questions page, a digital human, an app for SMS text messaging with health care providers, and an app for video-calling with health care providers. Using a semistructured interview guide based on domains of the Capability, Opportunity, Motivation, and Behavior (COM-B) model, participants were questioned about (1) their general opinion on the 4 telehealth channels, (2) factors influencing preference for individual telehealth channels, and (3) factors influencing preference for individual telehealth channels in relation to the other available channels. Interviews were recorded, transcribed, and categorically analyzed.

RESULTS

A total of 15 patients were interviewed (female: n=8, 53%; male: n=7, 47%; mean age 55, SD 16.8 years; median treatment duration of 41, IQR 12-106 months). The following 3 categories of factors influencing patient preference regarding telehealth channels were identified: (1) problem-related factors included problems needing a visual check, problems specifically related to the patient, and urgency of the problem; (2) patient-related factors included personal communication preference and patient characteristics; and (3) channel-related factors included familiarity with the telehealth channel, direct communication with a health care provider, methods of searching, and conversation history.

CONCLUSIONS

Preference for telehealth channels is influenced by factors related to the problem experienced, the patient experiencing the problem, and telehealth channel characteristics. As the preference for telehealth channels varies between these categories, multiple telehealth channels should be offered to enable patients to tailor the support with their medication use to their needs.
Comparative geochemical assessment of jotunite rocks from the Suwałki Massif and the Sejny Intrusion (NE Poland)
Authors: Grabarczyk Anna , Wiszniewska Jadwiga
Published: July 2023

Jotunites (hypersthene monzodiorites/ferromonzodiorites) are rocks coeval with plutonic AMCG (anorthosite– mangerite–charnockite–rapakivi granite) suites, which are characteristic of the Proterozoic Eon. It has been experimentally shown that jotunite magma can be recognised as parental to anorthosites and related rocks: since then, research on these rocks has taken on a particular importance. Jotunites were recently described within the deeply buried c. 1.5 Ga Suwałki and Sejny anorthosite massifs in the crystalline basement of NE Poland. The major and trace element compositions of Polish jotunites show them to have a calc-alkalic to alkali-calcic and ferroan character, with a relatively wide range of SiO2 content (40.56 wt. % up to 47.46 wt. %) and high concentrations of Fe (up to 22.63 wt. % Fe2O3), Ti (up to 4.34 wt. % TiO2) and P (up to 1.46 wt. % P2O5). Slight differences in textural features, mineralogical compositions, and geochemistry of whole-rock jotunite samples from distinct massifs allow us to distinguish two kinds: a primitive one, present in the Sejny Intrusion, and a more evolved one, related to the Suwałki Massif.
Vestiges of Cambro-Ordovician continental accretion in the Carpathian-Balkan orogen: First evidence of the ‘Cenerian event’ in the central Serbo-Macedonian Unit
Authors: Spahić Darko , Bojić Zoran , Popović Danica , Gaudenyi Tivadar
Published: July 2023

In the Balkans, the Serbo-Macedonian Unit (SMU), Serbia, is thrust bounded by the composite Tethyan Vardar Zone and the Carpatho-Balkanides. The SMU actually emerges from beneath the Neoalpine Miocene–Pliocene deposits. Both provenance and geodynamic position of the SMU are poorly known and still debated. This paper reviews the data hitherto published and includes some new field data interpretations. The SMU is composed of a Neoproterozoic–Cambrian high-grade (para- and ortho-) gneiss with peraluminous magmatic arc components (560–470 Ma). The SMU is in the contact with Neoproterozoic upper Ordovician–Carboniferous low-grade metasedimentary succession of an accretionary wedge assembly represented by the Supragetic basement. The SMU basement became folded, sheared and metamorphosed around 490–450 Ma. Paleomagnetic data point to high southern latitudes and a peri-Gondwanan position of the SMU at that time, which concurs with glaciomarine evidence recorded from the upper Ordovician sediments at the base of an accretionary wedge succession. Based on the published data and field survey in the Stalać region, we correlate the SMU with the pre-Mesozoic gneiss terrane exposed in the Strona-Ceneri zone of the Alps. This terrane, identified as the Cenerian orogen of the Alaskan subduction type, developed at an active margin of Gondwana during middle Ordovician times. The SMU basement, with augen and migmatitic gneisses and arc-related peraluminous magmatic bodies, developed at this margin as part of the Cenerian belt or its equivalent. Such an orogenic edifice proved transient and in the earliest Silurian the SMU fragments drifted away being bound for Baltica (amalgamated Moesian microplate and Danubian terrane) to which they became accreted in the Carboniferous and included in the southern European branch of the Variscan orogen (Marginal Dacides/Carpatho-Balkanides). Despite considerable Variscan and Alpine reworking, the pre-Variscan, Cenerian-type crustal assembly along with an inferred boundary between the magmatic arc and the accretionary wedge, accompanied by back-arc/forearc deposits, are still decipherable in the Western Balkan countries.
The Jurassic–Cretaceous transition in the High-Tatric succession (Giewont Unit, Western Tatra Mts, Poland): integrated stratigraphy and microfacies
Authors: Lodowski Damian Gerard , Pszczółkowski Andrzej , Wilamowski Andrzej , Grabowski Jacek
Published: July 2023

Herein are presented the results of detailed bio- (calcareous dinocysts, calpionellids, foraminifers, saccocomids) and chemostratigraphic (δ13C) studies combined with high-resolution microfacies, rock magnetic and gamma-ray spectrometry (GRS) investigations performed on the upper Kimmeridgian–upper Valanginian carbonates of the Giewont succession (Tatricum, Giewont and Mały Giewont sections, Western Tatra Mountains, Poland). The interval studied covers the contact between the Raptawicka Turnia Limestone (RTL) Fm. and the Wysoka Turnia Limestone (WTL) Fm. Their sedimentary sequence is composed of micrites, pseudonodular limestones, cyanoid packstones, lithoclastic packstone and encrinites. A precise correlation with the previously published Mały Giewont section is ensured by biostratigraphy, rock magnetic and GRS logs. The methodology adopted has enabled the recognition of two stratigraphic discontinuities, approximated here as corresponding to the latest Tithonian–early (late?) Berriasian and the early Valanginian. The hiatuses are evidenced by biostratigraphic data and the microfacies succession as well as by perturbations in isotopic compositions and rock magnetic logs; they are thought to result from a conjunction of tectonic activity and eustatic changes. A modified lithostratigraphic scheme for the Giewont and the Osobita High-Tatric successions is proposed. The top of the RTL Fm. falls in the upper Tithonian, where cyanoid packstones disappear. At the base of the WTL Fm. a new Giewont Member is defined as consisting of a basal lithoclastic packstone and following encrinites.
Project Management Methodologies in the Organizations of Yesterday, Today and Tomorrow
Authors: Niță Nicoleta-Madălina , Stan Sebastian-Emanuel , țîțu Aurel Mihail
Published: July 2023

The history has shown us over time that each way of managing an activity can lead to a different result, which has given rise to multiple approaches to the project management discipline through diverse models and methodologies, each one coming with a number of advantages and disadvantages. The software engineering branch is a climate where projects have a lot of room for flexibility, change and adaptability. However, this scientific paper aims to highlight the characteristics of these techniques, provided by experts in the field through the scientific literature, along with an original point of view regarding their future improvement. Project management is a complex, diverse and encompassing discipline, so each new model or methodology has come to supplement the shortcomings of the previous one. Starting from these, there are a number of factors that must be taken into account when determining how a project should be managed, such as: industry, size, resources, etc., and this paper presents the areas of applicability for each methodology in part, as well as data in which several approaches intertwine resulting in hybrid project management approaches. In the end, some conclusions and predictions about the methodologies in the field of software development industry are presented.
KONSEP KEBENARAN DALAM PEMILIKAN TANAH DI INDONESIA
Authors: Sihombing Irene Eka
Published: July 2023

Tanah adalah permukaan bumi yang dalam penggunaannya meliputi ruang yang ada di bawah dan di atas permukaan bumi tersebut. Pengaturan tentang pemilikan tanah di berbagai Negara, didasarkan kepada latar belakang, konsepsi yang berbeda-beda. Sebelum UUPA konsep pemilikan tanah di Indonesia bersifat individualistik, di mana Negara menyatakan sebagai pemilik tanah. Sejak UUPA, pemilikan tanah di Indonesia didasarkan kepada konsep bahwa tanah di seluruh wilayah Indonesia adalah karunia Tuhan Yang Maha Esa kepada Bangsa Indonesia. Dengan demikian maka konsepsinya adalah komunalistik religius.  Batas-batas Negara yang semakin “kabur” dapat berakibat kepada saling berpengaruhnya konsep pemilikan tanah di Negara-negara yang mempunyai sistem hukum berbeda. Mengingat bahwa kebenaran itu bukan suatu harga mati, maka dapat saja terjadi pengaruh pemilikan tanah antar Negara termasuk   pemilikan tanah di Indonesia. Pokok permasalahan yang menjadi dasar tulisan ini adalah apakah pemilikan tanah di Indonesia saat ini dianggap sebagai konsep yang benar? Mengapa konsep pemilikan tanah di Indonesia perlu dipertahankan? Kebijakan yang menghendaki perluasan pemilikan tanah oleh orang asing, pemilikan tanah dengan jangka waktu yang lebih panjang, melupakan Hukum Adat sebagai sumber utama dan pelengkap dalam Hukum Tanah Nasional adalah beberapa fakta untuk menggeser kebenaran dalam pemilikan tanah di Indonesia
Prediksi Tren Pergerakan Harga Saham PT Bank Central Asia Tbk, Dengan Menggunakan Algoritma Long Shot Term Memory (LSTM)
Authors: Wathani M. Nurul , Kusrini Kusrini , Kusnawi Kusnawi
Published: July 2023

Shares are valuable documents that prove ownership of a company. Stock investment is one of the right choices to get more profit. There are various stocks in Indonesia, one of which is the shares of PT Bank Central Asia Tbk (BBCA). However, in making stock investments, it is necessary to analyze the data of a company that can determine the increase or decrease in a stock price. Very dynamic movements require data modeling to predict stock prices in order to get a high level of accuracy. In this study, modeling using the Long-Short Term Memory (LSTM) algorithm to predict BBCA stock prices. The data used is secondary daily data obtained from securities with a date range of January 3, 2011 to December 30, 2022. The main objective of this research is to analyze the accuracy of the LSTM algorithm in forecasting stock prices and to analyze the number of epochs in the formation of the optimal model. The optimal epoch variation is obtained with the number of epochs of 5 and batch size 1. The resulting values include Mean Absolute Error (MAE) of 96.92, Mean Squared Error (MSE) of 16185.22 and Root Mean Squared Error (RMSE) of 127.22. The results of this study provide further insight into the performance of the LSTM algorithm in stock price prediction and show that with the right parameter settings, it can be a useful tool for investors in making better investment decisions
Xử lý Nitơ và Phốtpho trong nước thải
Authors: Nguyen Minh Ky
Published: July 2023

Hướng dẫn xử lý N và P trong nước thải.
Daño pulmonar agudo en el parénquima pulmonar asociado al consumo de cigarrillo tradicional vs. cigarrillo electrónico
Authors: Machado Serrano Ana Isabel , Cardoso Landivar José David
Published: July 2023

Introducción: El tabaquismo es la principal causa individual de muertes prevenibles en el mundo por lo que actualmente debido al daño asociado a tabaco se han incorporado nuevas alternativas a los cigarrillos tradicionales, como los cigarrillos electrónicos sin embargo, debido al consumo de estos, existen nuevos informes acerca del síndrome de lesión pulmonar asociado con el uso de cigarrillos electrónicos o productos de vapeo (EVALI) por lo que esta revisión busca detallar cuales son estas lesiones que se producen y compararlas con las lesiones del consumo de cigarrillo tradicional. Objetivo: El objetivo de la presente investigación ha sido realizar una revisión de la bibliografía acerca de las características patológicas que se pueden presentar por el consumo de estos dispositivos. Metodología: Se realizó  una  revisión  bibliográfica narrativa acerca  del  daño pulmonar agudo en el parénquima pulmonar asociado al consumo de cigarrillo tradicional vs. cigarrillo electrónico realizando una búsqueda en diferentes bases de datos como pubmed, scopus, elsevier. Desarrollo: Se piensa que el acetato de vitamina E puede ser uno de las sustancias que se encuentran en el líquido para cigarrillos electrónicos que tenga mayor asociación con EVALI, a su vez los endulzantes y saborizantes que se utilizan en estas preparaciones aumentar la probabilidad de que las personas prueben los productos de cigarrillos electrónicos o continúen usándolos facilitando el uso de nicotina en estos dispositivos ya que enmascaran las propiedades aversivas de la nicotina. En cuanto a las lesiones agudas encontradas por cigarrillo tradicional se detalló la neumonía eosinofílica aguda, la cual comparándola con los hallazgos patológicos causados por EVALI se observó similitudes como la hiperplasia de neumocitos tipo II, el aumento de la cantidad de fibrina intraalveolar e infiltración eosinofílica. Conclusión: Tanto los cigarillos electrónicos como los tradicionales pueden llega a presentar patologías agudas, diferenciandolas en neumonía eosinofílica aguda y EVALI por lo que el cambio a cigarrillos electrónicos no presenta ningun beneficio para el consumidor. Área   de   estudio   general: medicina. Área de estudio específica: Neumología, Patología.
SELENOF Controls Proliferation and Cell Death in Breast-Derived Immortalized and Cancer Cells
Authors: Ekyalongo Roudy C. , Flowers Brenna , Sharma Tanu , Zigrossi Alexandra , Zhang An , Quintanilla-Arteaga Anaisa , Singh Kanishka , Kastrati Irida
Published: July 2023

SELENOF expression is significantly lower in aggressive breast tumors compared to normal tissue, indicating that its reduction or loss may drive breast tumorigenesis. Deletion of SELENOF in non-tumorigenic immortalized breast epithelial MCF-10A cells resulted in enhanced proliferation, both in adherent culture and matrix-assisted three-dimmensional (3D) growth. Modulation of SELENOF in vitro through deletion or overexpression corresponded to changes in the cell-cycle regulators p21 and p27, which is consistent with breast tumor expression data from the METABRIC patient database. Together, these findings indicate that SELENOF affects both proliferation and cell death in normal epithelial and breast cancer cells, largely through the regulation of p21 and p27. In glandular cancers like breast cancer, the filling of luminal space is one of the hallmarks of early tumorigenesis. Loss of SELENOF abrogated apoptosis and autophagy, which are required for the formation of hollow acini in MCF-10A cells in matrix-assisted 3D growth, resulting in luminal filling. Conversely, overexpression of SELENOF induced cell death via apoptosis and autophagy. In conclusion, these findings are consistent with the notion that SELENOF is a breast tumor suppressor, and its loss contributes to breast cancer etiology.
Promising Highly Targeted Therapies for Cholangiocarcinoma: A Review and Future Perspectives
Authors: Kuwatani Masaki , Sakamoto Naoya
Published: July 2023

To overcome the poor prognosis of cholangiocarcinoma (CCA), highly targeted therapies, such as antibody-drug conjugates (ADCs), photodynamic therapy (PDT) with/without systemic chemotherapy, and experimental photoimmunotherapy (PIT), have been developed. Three preclinical trials have investigated the use of ADCs targeting specific antigens, namely HER2, MUC1, and glypican-1 (GPC1), for CCA. Trastuzumab emtansine demonstrated higher antiproliferative activity in CCA cells expressing higher levels of HER2. Similarly, “staphylococcal enterotoxin A-MUC1 antibody” and “anti-GPC1 antibody-monomethyl auristatin F” conjugates showed anticancer activity. PDT is effective in areas where appropriate photosensitizers and light coexist. Its mechanism involves photosensitizer excitation and subsequent reactive oxygen species production in cancer cells upon irradiation. Hematoporphyrin derivatives, temoporfin, phthalocyanine-4, talaporfin, and chlorine e6 derivatives have mainly been used clinically and preclinically in bile duct cancer. Currently, new forms of photosensitizers with nanotechnology and novel irradiation catheters are being developed. PIT is the most novel anti-cancer therapy developed in 2011 that selectively kills targeted cancer cells using a unique photosensitizer called “IR700” conjugated with an antibody specific for cancer cells. PIT is currently in the early stages of development for identifying appropriate CCA cell targets and irradiation devices. Future human and artificial intelligence collaboration has potential for overcoming challenges related to identifying universal CCA cell targets. This could pave the way for highly targeted therapies for CCA, such as ADC, PDT, and PIT.