bluuebunny/crossref_metadata_2025 huggingface dataset:
Arthroscopic Superior Capsular Reconstruction with Dermal Allograft for the Treatment of a Massive Irreparable Rotator Cuff Tear
Authors: Chahla Jorge , Cancienne Jourdan M. , Beletsky Alexander , Manderle Brandon J. , Verma Nikhil N.
Published: September 2020

A massive, irreparable rotator cuff tear represents a challenging treatment scenario with respect to surgical intervention. Traditionally, surgical options have included reverse total shoulder arthroplasty, hemiarthroplasty, or rotator cuff repair; however, these techniques may not necessarily restore proper anatomy to the superior capsule, a structure implicated in the maintenance of subacromial contact pressures and the prevention of superior glenohumeral translation. Indications for arthroscopic superior capsular reconstruction include massive, irreparable supraspinatus and/or infraspinatus tears and failure of conservative treatment beyond subjective pain thresholds and dysfunction tolerability. Adequate latissimus dorsi, pectoralis major, and deltoid function helps to ensure the appropriate level of shoulder stability and the ability to complete the necessary rehabilitation protocol. The current surgical guide details the clinical evaluation, surgical technique, and rehabilitation protocol for patients undergoing arthroscopic superior capsular reconstruction for a massive, irreparable rotator cuff tear involving the subscapularis, supraspinatus, and infraspinatus. The procedure is performed arthroscopically with the patient in a beach-chair position, starting first with anterior and lateral portal placement for comprehensive diagnostic shoulder arthroscopy assessing rotator cuff damage. Single-row suture repair of the subscapularis and infraspinatus is performed, followed by concomitant subacromial bursectomy, decompression, and coracoplasty to aid in visualization, avoid graft abrasion, and provide access to marrow elements. Suture anchor placement, allograft fixation, and appropriate suture management are highlighted, as well as rehabilitation timelines, complications, and clinical pearls.
Knee Arthrodesis for Recurrent Periprosthetic Knee Infection
Authors: Conway Janet D.
Published: September 2020

Background:

Knee arthrodesis for recurrent periprosthetic knee infection is a limb salvage procedure that simultaneously provides a stable limb for weight-bearing and effective eradication of the chronic infection. Knee arthrodesis is a final resort for limb salvage that is appropriate for patients with multiple recurrent revisions for infection, a history of failed 2-stage exchanges, medical comorbidities, and an inability to tolerate multiple additional procedures. Another important consideration is whether the patient has a poor soft-tissue envelope that leaves knee arthrodesis as the only viable option. The procedure is a definitive surgery to eliminate return trips to the operating room.

Description:

This technique involves knee arthrodesis using a long intramedullary rod inserted proximally through the piriformis fossa that spans the entire medullary canal of the femur and the tibia. Before insertion, the surgeon may elect to create a long antibiotic cement-coated intramedullary rod. The rod is locked proximally and distally. An alternative method for large bone defects (>6 cm) at the level of the knee is to create intercalary antibiotic-impregnated cement spacers.

Alternatives:

Alternative surgical treatments for this problem include above-the-knee amputation or resection arthroplasty, neither of which provides a functional limb for weight-bearing. The most common alternative methods for knee arthrodesis include external fixation using circular or biplanar frames, as well as short intramedullary modular rods.

Rationale:

Knee arthrodesis using a long intramedullary rod is a very effective and efficient method of fusion. With recurrent periprosthetic knee infections, metaphyseal bone loss is common and short knee-fusion rods may not provide adequate stability. Long rods for knee arthrodesis use the diaphysis for stability and have the additional advantage of being easily accessible for removal in the event of a recurrent infection with a well-healed fusion. Long intramedullary rods also provide the additional advantages of immediate weight-bearing. Immediate weight-bearing on the affected limb is critical because often these patients have been unable to bear weight preoperatively secondary to pain and infection. External fixation techniques are effective but come with pin-site problems. Pin-site problems are amplified in patients with obesity who have large soft-tissue envelopes, and the long intramedullary rod avoids pin problems in such patients. Antibiotic cement coating of the long intramedullary rod also provides local antibiotic delivery.
No Increased Risk of Alopecia in Ankylosing Spondylitis Patients: A Population-based Cohort Study in Taiwan
Authors: Hsieh Jason Peijer , Tsou Hsi-Kai , Lee Yung-Heng , Wang Yu-Hsun , Wei James Cheng-Chung
Published: September 2020

The authors have requested that this preprint be withdrawn due to erroneous posting.
The Efficacy of the Comprehensive Assessment and Multi-Disciplinary Management of Geriatric and Frail Patients: The Study Protocol of a Multi-Center, Randomized, Parallel Controlled Trial (MDT-F)
Authors: Yao Simin , Zheng Peipei , Ji Liwei , Ma Zhao , Wang Lijuan , Qiao Linlin , Wan Yuhao , Sun Ning , Luo Yao , Yang Jiefu , Wang Hua
Published: September 2020

Background: A comprehensive geriatric assessment (CGA) of elderly patients is useful for detecting the patients' vulnerabilities. Exercise and early rehabilitation, nutritional intervention, traditional Chinese medicine (TCM), standardized medication guidance and patient education can, separately, improve and even reverse the physical frailty status. However, the effect of combining a CGA and multi-disciplinary management on frailty in elderly patients remains unclear. The present study assessed the effects of a CGA and multi-disciplinary management on elderly patients with frailty in China.Methods: In this study, 320 inpatients with frailty ≥70 years old will be randomly divided into an intervention group and a control group. The intervention group will be given routine management, a CGA and multi-disciplinary management involving rehabilitation exercise, diet adjustment, multi-drug evaluation, acupoint massage in TCM and patient education for 12 months, and the control group will be followed up with routine management for basic diseases. The primary outcomes are the Fried phenotype and short physical performance battery (SPPB). The secondary outcomes are the clinical frailty scale (CFS), non-elective hospital readmission, basic activities of daily living (BADL), 5­level european quality of life 5 dimensions index (EQ-5D), nutrition risk screening-2002 (NRS-2002), medical insurance expenses, fall events and all-cause mortality. In addition, a cost-effectiveness study will be carried out. Discussion: This paper outlines the protocol for a randomized, single-blind, parallel multi-center clinical study. This protocol, if beneficial, will demonstrate the interaction of various intervention strategies, will help improve elderly frailty patients, and will be useful for clinicians, nurses, policymakers, public health authorities and the general population.Trial registration: Chinese Clinical Trials Register, ChiCTR1900022623. Registered on 19 April 2019, http://www.chictr.org.cn/showproj.aspx?proj=38141.
Circular RNA expression profiles in the development of acute chronic liver failure in hepatitis B virus-infected patients
Authors: Lian Jiangshan , Lin Feiyan , Lu Yinfeng , Hao Shaorui , Yu Jiong , Cai Huan , Zhang Xiaoli , Gu Yuqing , Yang Yida , hu lufeng
Published: September 2020

Hundreds of millions of people worldwide suffer from chronic hepatitis B (CHB), which is thus among the most serious public health problems. CHB can lead to serious acute chronic liver failure (ACLF). Since ACLF has a very high mortality rate, prediction of ACLF risk is a critical issue in clinical practice. To investigate the development of ACLF from CHB, circular RNA (circRNA), a novel type of endogenous non-coding RNA, was examined in healthy control (HC) subjects and CHB and ACLF patients using high-throughput RNA sequencing technology. Differentially expressed circRNAs were selected and analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) biological pathway analyses, circRNA-miRNA co-expression networks, and statistical analyses.The results showed that a total of 21,101 circRNAs were identified in HC, CHB and ACLF subjects. Compared with the HCs, 4 up-regulated and 14 down-regulated circRNAs were identified in ACLF subjects, which exhibited a consistent trend of change in the three groups. GO analysis revealed that regulation of lymphocyte activation and macrophage tolerance induction were the most important biological processes in ACLF progression. KEGG pathway analysis revealed that primary immunodeficiency and NOD-like receptor signaling pathways were the most enriched terms. The circRNA-miRNA co-expression network and statistical analyses showed that circRNA_07734, circRNA_08533, and circRNA_16083 were the most important circRNAs in the process of ACLF. In conclusions, immune dysfunction and immunodeficiency may be critical in the development of ACLF, which results in aberrant expression of circRNAs, especially circRNA_07734, circRNA_08533, and circRNA_16083.
Conjunctive Use of BTC and Batch Methods for Heavy Metal Transport
Authors: Hussein Mohamed Fahmy , Khater Hassan
Published: September 2020

Marginal sediments can be used to combat point-pollution by heavy metals in industrial zones. Such practice requires information on metal-concentration in the workshop discharge water. Knowledge about the reaction of the heavy metal with the sediment available in the landscape is of utmost importance. Modeling of batch experiments and breakthrough curves, BTC, supplies relevant information in this regard. We present the static batch results of Freundlich isotherms testing CdCl2 aqueous solutions equilibria with sandy loam sediments, along with column-data processed by the dynamic codes CfitM and CfitIM under saturated water flow conditions. Three Cd-concentrations (5, 20, and 40 ppm) were employed to investigate the conjunction of using two procedures for obtaining the pertinent parameters for the transport of such a heavy metal and the design of the adequate Cd-trap. The results showed the deviations of the two techniques due to differences in their theoretical concepts, mathematical formulation, and performance. The batch method showed utility in supplying first guesses for the retardation factor, R, to insert into the 4-parameter analytical code, CfitIM, applied for column BTC modeling. The iteratively-obtained-parameters of the Freundlich equation were then employed to generate the distribution coefficient, k d. The generated value was, in turn, used to get more fair guess for the retardation factor, R, to use as a fixed-value in the CfitIM code to get an in-depth insight into the BTC dynamics and to obtain the other pertinent model parameters. The BTC runs indicated that the concentration controls the distinctive adsorption and transport rate and behavior of the heavy metal in the sediment column. The most dilute solution offered the highest Cd impediment, as shown by the most significant values for the distribution coefficient, k d, and retardation factor, R. The malfunction of the sediment as a trap appeared at Cd-concentrations four to eight folds higher than the most dilute solution. However, the loamy sand trap is successful when fed with a dilute aqueous solution. A set of successive traps is to arrange in tandem lines when moderate to high concentration is to discharge from an industrial workshop. The results emphasize the utility of the mutual use of these two lab procedures for the design of adequate traps and landfills and the simulation of more complex situations in the field. The point-pollution control needs to continue running batch and BTC experiments and to carry out their corresponding modeling.
Anatomic Relationship Between the Radial Nerve and the Musculo-Fascial Structures of the Arm and Forearm: A Cadaveric and Sonographic Study
Authors: Martínez José García , Alvarez Gerard , Perez-Bellmunt Albert , Miguel Maribel , Viscor Ginés
Published: September 2020

Background: Radial nerve (RN) compression most commonly occurs at the level of the supinator arch (SA), also called arcade of Fröhse, but other sites of entrapment along the course of the nerve are possible. This study aimed to perform an ultrasound and anatomical examination of these entrapment sites, to provide a solid anatomical base for the differential diagnosis of lateral arm pain, to allow a more precise manual therapy approach. Methods: Nineteen fresh-frozen cadavers were examined, first on ultrasound then on anatomical dissection. Two points of possible RN entrapment were injected with dye under ultrasound guidance: where the RN crosses the lateral intermuscular septum (LIMS) and at the SA. Dissection confirmed the location of the dye at these points and allowed us to describe the relationship of the RN with the adjacent structures; the distances from each of these two points to the lateral epicondyle and the diameter of the RN were also measured. Results: The dye was observed in the correct place in all specimens. We observed a close relationship of the RN with the lateral head of triceps brachialis (LHTB) muscle and the LIMS as it passed through these structures. In both structures, longitudinal aponeurotic extensions were observed. In the anterior compartment of the arm, where the RN glides between the brachialis (B) and brachioradialis (BR) muscles, we observed varying relationships between these three structures (5% had vascular unions, 79% had union of the epimysium, and 16% muscular unions). Finally, in the forearm, just before reaching the SA, we observed a septum that compartmentalize the forearm musculature and created an aponeurotic arch through which the motor branch of the RN passed. Conclusions: Ultrasound study helps correctly identify the RN; the two points identified on US and dissection correlated well. The anatomical findings on the relationship of the RN with its surrounding structures may explain its entrapment.
WITHDRAWN: Nicotinamide Attenuates Streptozotocin-Induced Diabetes Complications and Increases Survival Rate in Rats: Role of Autonomic Nervous System.
Authors: Cruz Paula Lázara , Moraes-Silva Ivana Cinthya , Ribeiro Amanda Aparecida , Machi Jacqueline Freire , Melo Marcelo Dantas Tavares , Santos Fernando dos , Silva Maikon Barbosa da , Strunz Celia Maria Cassaro , Caldini Elia Garcia , Irigoyen Maria Cláudia C
Published: September 2020

Background: Diabetes induced by streptozotocin (STZ) is a well-known model to study diabetes complications in rats and mice. The association of nicotinamide (N) with STZ has been widely used, and the severity of diabetes is attenuated. However, the mechanisms supporting this attenuation are not completely understood. Considering the key role of the autonomic nervous system in the pathophysiology of several diseases, we hypothesized that N could affect baroreflex sensitivity and autonomic modulation, thus protecting from the aggressive effects of STZ. Methods: Male Wistar rats were divided into control (C) and STZ-induced diabetes (D). Half of the rats from each group received a single dose of N (100mg/Kg) before STZ injection (CN and DN). All groups were followed-up for 5 weeks. Results: Body weight loss of more than 40% was observed in D throughout the period (D: 271.00±12.74 g; DN: 344.62±17.82). Increased glycemia was seen in D rats (541.28±18.68 mg/dl) while DN group had a slight decrease (440.87±20.96 mg/dl). However, insulin resistance was observed only in D. In relation to C, heart rate, mean blood pressure and diastolic function were reduced when compared to D, together with parasympathetic modulation (RMSSD D: 5.4±0.2 ms and DN: 9.3±1.2 ms) and baroreflex sensitivity. All of these parameters were improved in DN when compared to D. Improved baroreflex sensitivity and parasympathetic modulation were correlated with glycemia, insulin resistance, and body weight mass. Additionally, DN group increased survival rate. Conclusions: These results suggest that the association of nicotinamide in STZ-induced diabetic rats prevents most of the expected derangements mainly by preserving parasympathetic and baroreflex parameters.
Highly Specific and Ultrasensitive Plasma Test Detects Abeta(1-42) and Abeta(1-40) in Alzheimer’s Disease
Authors: Thijssen Elisabeth H , Verberk Inge M.W. , Vanbrabant Jeroen , Koelewijn Anne , Heijst Hans , Scheltens Philip , Flier Wiesje van der , Vanderstichele Hugo , Stoops Erik , Teunissen Charlotte E.
Published: September 2020

BACKGROUND Plasma biomarkers that reflect specific amyloid beta (Abeta) proteoforms are essential to monitor treatment effects of Alzheimer’s disease (AD) therapies. Our aim was to develop and validate ready-to-use Simoa ‘Amyblood’ assays that measure full length Abeta1-42 and Abeta1-40 and compare their performance with two commercial assays. METHODS Linearity, intra- and inter-assay %CV were compared between Amyblood, Quanterix Simoa triplex, and Euroimmun ELISA. Sensitivity and selectivity were assessed for Amyblood and the Quanterix triplex. Clinical performance was assessed in CSF biomarker confirmed AD (n=43, 68±6 years) and controls (n=42, 62±5 years). RESULTS Prototype and Amyblood showed similar calibrator curves and differentiation (20 AD vs 20 controls, p<0.001). Amyblood, Quanterix triplex, and ELISA showed similar linearity (96%-122%) and intra-assay %CVs (≤3.1%). A minor non-specific signal was measured with Amyblood of +2.4 pg/mL Abeta1-42 when incubated with 60 pg/mL Abeta1-40. A substantial non-specific signal of +24.7 pg/mL Abetax-42 was obtained when 40 pg/mL Abeta3-42 was measured with the Quanterix triplex. Selectivity for Abeta1-42 at physiological Abeta1-42 and Abeta1-40 concentrations was 125% for Amyblood and 163% for Quanterix. Amyblood and Quanterix ratios (p<0.001) and ELISA Abeta1-42 concentration (p=0.025) could differentiate AD from controls. CONCLUSIONS We successfully developed and upscaled a prototype to the Amyblood assays with similar technical and clinical performance as the Quanterix triplex and ELISA, but better specificity and selectivity than the Quanterix triplex assay. These results suggest leverage of this specific assay for monitoring treatment response in trials.
A Novel Rat Model of Persistent Gouty Arthritis by Minimally Invasive Saturated Msu Embedding 
Authors: Xu Hanlin , Li ShengKun , Xue XiaoAo , Chen ZiYi , Hua Yinghui
Published: September 2020

Background: Animal models are valid for in vivo research on the pathophysiological process and drug screening of gout arthritis. Intra-articular injection of monosodium urate (MSU) is commonly used to establish animal model at present, while stable MSU deposition and tophi formation were rarely reported. Method: A total of twenty-four rats were randomly allocated into six groups. Three intervention groups of rats received MSU embedment for 3-5 times, respectively. Sham groups received pseudo surgeries with normal saline (NS). Gross parameters and pathological features of synovium harvested from anterior capsule. Mechanical pain threshold tests of rats were conducted over a 96-hour period postoperatively. Result: Significant synovial swelling was detected in the MSU group compared to the sham group(P<0.05). Behavioral tests showed that the embedding of MSU resulted in prolonged mechanical hyperalgesia (P<0.05 during 2 hours to 96 hours postoperatively). MSU depositions enveloped by neutrophil extracellular traps (NETs) were detected where the IL-1β and TNF-α were co-expressed in embedding groups. Quantitative immunofluorescence suggested that the frequencies of MSU interventions promoted expression of proinflammatory factors (P<0.05).Conclusion: A minimally invasive surgical method was developed to establish the novel rat model of intra-articular MSU deposition. This model was proved to be a simple reproducible method to mimic the pathological characteristics of intra-articular crystal arthritis.
Genome-Wide Mapping of Histone Modifications in Two Species of Leptosphaeria Maculans Showing Contrasting Genomic Organization and Host Specialization
Authors: Soyer Jessica Louise , Clairet Colin , Gay Elise J. , Lapalu Nicolas , Rouxel Thierry , Stukenbrock Eva H. , Fudal Isabelle
Published: September 2020

BackgroundIn plant-associated fungi, the epigenome is increasingly recognized as an important regulator of the expression of genes involved in interaction with the host plant. Leptosphaeria maculans ‘brassicae’ (Lmb) and Leptosphaeria maculans ‘lepidii’ (Lml) are closely-related phytopathogenic species that exhibit a large macrosynteny but contrasting genome structure. Lmb has more than 30% of repeats clustered in large repeat-rich regions, while the Lml genome has only a small amount of evenly distributed repeats. Repeat-rich regions of Lmb are enriched in effector genes, expressed during plant infection. The distinct genome structures of Lmb and Lml provide an excellent model for comparing the organization of pathogenicity genes in relation to the chromatin landscape in two closely related phytopathogenic fungi. Here, we performed chromatin immunoprecipitation (ChIP) during axenic culture, targeting histone modifications typical for heterochromatin or euchromatin, combined with transcriptomic analysis to analyse the influence of chromatin organisation on gene expression.ResultsIn both species, we found that facultative heterochromatin are enriched with genes lacking functional annotation, including numerous effector and species-specific genes. Notably, orthologous genes located in H3K27me3-domains are enriched with effector genes. Compared to other fungal species, including Lml, Lmb is distinct in having large H3K9me3-domains associated with repeat-rich regions that contain numerous species-specific effector genes. ConclusionDiscovery of these two distinctive heterochromatin landscapes now raises questions about their involvement in the regulation of pathogenicity, the dynamics of these domains during plant infection, and the selective advantage to the fungus to host effector genes in H3K9me3- or H3K27me3-domains.
Prognostic and Predictive Values of MAD2L1 in Cholangiocarcinoma
Authors: Gao Yuan , Ouyang Xiwu , Luo Tianping , Zhu Chunfu , Qin Xihu
Published: September 2020

Background: This study aimed to investigate the expression of Mitotic arrest deficient 2-like protein 1 (MAD2L1) in cholangiocarcinoma (CCA) and its biological function. Methods: Our study performed bioinformatics to analyze the microarray data from the Gene Expression Omnibus (GEO) database and obtained the differentially expressed genes (DEGs). Enrichment assay and protein-protein interaction networks analysis were conducted to extract hub genes. Mitotic arrest deficient 2-like protein 1 (MAD2L1) was investigated in tumor and adjacent nonneoplastic biliary ducts in 42 samples by immunohistochemistry. Subsequently, MAD2L1 was manipulated, and its function was examined in CCA cell lines and in vivo model. Results: 297 DEGs were extracted from the microarray data. And seven hub genes were defined through the enrichment assay and protein-protein interaction networks analysis. MAD2L1 was picked up as a novel biomarker, according to hierarchical cluster analysis and Kaplan-Meier survival analysis. MAD2L1 was specifically expressed in cancer tissues but not in the surrounding normal tissue, and 31 (73.81%) of 42 CCAs were MAD2L1 positive by immunohistochemistry. MAD2L1 expression was significantly correlated with tumor size, pathological grade, and clinical stage. Kaplan-Meier analysis demonstrated an inverse correlation between MAD2L1 expression and overall survival. Real-time polymerase chain reaction (RT-PCR) and Immunoblotting results further confirmed the results of immunohistochemistry and bioinformatic analysis from the database. In vitro and in vivo models, decreasing MAD2L1 could significantly suppress tumor growth.Conclusion: High MAD2L1 expression predicts the advanced stage of CCA. Targeting MAD2L1 may be a potential tumor suppressor and may provide the biological basis for a new therapeutic strategy.Trial registration: [2020]KY157-01. Registered 1st April 2020 - Retrospectively registered, http://114.255.48.20/login#.
Bacterial Assessment and Their Antibiotic Sensitivity Patterns of Nasal and Hand Swab Specimens From Food Handlers in Hospital Compounds in Mandalay, Myanmar: A Cross-sectional Descriptive or Observational Study
Authors: Aung Si Thu , Nwe Aung Aung
Published: September 2020

Background: Microbial contamination of food can occur from contaminated or infected food handlers.Methods: This study aimed to assess type of bacteria and their antibiotic sensitivity pattern of nasal and hand swab samples from food handlers working in hospital compounds, Mandalay city, Myanmar. All eligible food handlers working in the government hospital compound, Mandalay City, Myanmar, were subjected to a cross-sectional study conducted from May to August 2018. Hand and nasal swabs were collected from of food handlers for bacterial isolation and identification. Antibiotic sensitivity patterns of isolated bacteria were determined.Results: Among 111 participants, 92 (82.9%) were bacteria-positive by hand swabs and 77(69.37%) were positive by nasal swab. Among Staphylococcus aureus isolated from nasal swabs, just over a half (51.2%) were resistant to oxacillin (probably methicillin resistant Staphylococcus aureus). There were association between hand contamination and nasal bacterial growth (p<0.001).Conclusion: Bacterial contamination status of the food handler working in hospital compound, Mandalay city, Myanmar, was extremely high.
Derivation and Validation of the ED-SAS Score for Very Early Prediction of Mortality and Morbidity with Acute Pancreatitis: A Retrospective Observational Study
Authors: Miller Joseph , MD  , Safa Rawan , Marusca Georgiana , Bhatti BS Sandeep , Ahluwalia Guneet , Dandashi Jad , Acevedo Harold Gomez , Farook Naureen , Scott Ashley , Nair Vidhya , Adhami Angie , Dueweke Jeffrey , Hebbar Sudarshan , Ekstrom Leeland
Published: September 2020

Background: Existing scoring systems to predict mortality in acute pancreatitis may not be directly applicable to the emergency department (ED). The objective of this study was to derive and validate the ED-SAS, a simple scoring score using variables readily available in the ED to predict mortality in patients with acute pancreatitis.Methods: This retrospective observational study was performed based on patient level data collected from electronic health records across 2 independent health systems, one used for the derivation cohort and one for the validation cohort. Adult patients who were eligible presented to the ED, required hospital admission, and had a confirmed diagnosis of acute pancreatitis. Patients with chronic or recurrent episodes of pancreatitis were excluded. The primary outcome was 30-day mortality. Analyses tested and derived candidate variables to establish a prediction score and that was subsequently applied to the validation cohort to assess odds ratio for the primary and secondary outcomes. Results: The derivation cohort included 599 patients, and the validation cohort 2011 patients. Thirty-day mortality was 4.2% and 3.9% respectively. From the derivation cohort, 3 variables were established for use in the predictive scoring score: ≥2 systemic inflammatory response syndrome (SIRS) criteria, age >60 years, and SpO2 <96%. Summing the presence or absence of each variable yielded an ED-SAS score ranging from 0 to 3. In the validation cohort, the odds of 30-day mortality increased with each subsequent ED-SAS point: 4.4 (95% CI 1.8 – 10.8) for 1 point, 12.0 (95% CI 4.9 – 29.4) for 2 points, and 41.7 (95% CI 15.8 – 110.1) for 3 points (c-statistic = 0.77).Conclusion: An ED-SAS score that incorporates SpO2, age, and SIRS measurements provides a rapid method for predicting 30-day mortality in acute pancreatitis.
Adverse Effects of Pre-pregnancy Maternal Underweight on Pregnancy and Perinatal Outcomes in a Freeze-all Policy
Authors: Tang Shengluan , Huang Jialyu , Lin Jiaying , Kuang Yanping
Published: September 2020

Background: Underweight and overweight may affect reproduction and interfere with treatment of infertility. In the present retrospective analysis, we sought to evaluate the effect of low body mass index (BMI) on pregnancy and perinatal outcomes in frozen–thawed embryo transfer (FET) cycles. Methods: This study involved 8,755 FET cycles in a single IVF center during the period from January 2009 to December 2018. Both pregnancy and perinatal outcomes were assessed in women who were underweight, normal weight, and overweight as defined based on a respective BMI < 18.5 kg/m2, ≥ 18.5 BMI <24.9 kg/m2, and BMI ≥ 25 kg/m2.Results: Being underweight was linked to reduced implantation rates as compared to a normal weight (33.56% vs. 37.26%). Similarly, when comparing outcomes in underweight women to those in normal weight women, rates of clinical pregnancy (48.14% vs. 53.85%) and ongoing pregnancy (43.04% vs. 50.47%) were reduced. Rates of miscarriage were markedly reduced in the normal weight group relative to the overweight group (10.73% vs. 13.37%). Perinatal outcomes were largely comparable for all groups, with the exception of very low birth weight rates (normal weight:0.58% vs. overweight: 2.03%) and very preterm delivery rates (normal weight:0.82% vs. overweight: 2.03%), which were significantly elevated for overweight mothers.Conclusions: These results indicate that being underweight is linked to negative pregnancy outcomes when undergoing FET-based IVF.
The Effect of Covid-19 on Anxiety, Quality of Work Life and Fatigue of Health Care Providers in Health Care Centers
Authors: Dehkordi Ali Hasanpour , Gholamzad Shakiba , Myrfendereski Sam , Dehkordi Ayda Hasanpour
Published: September 2020

Background and Aim: The aim of this study was to investigate the effect of Covid-19 on anxiety, quality of work life and fatigue of health center staff in southwestern Iran. Materials and Methods: The present study was a descriptive comparative study and the statistical population of the study included the staff of health centers of Shahrekord University of Medical Sciences. Using random sampling method, 181 people who had direct involvement with patients with Covid-19 were selected and compared with 261 staff in other wards who had no direct contact with patients with Covid-19. For data collection, demographic information (demographic characteristics questionnaire) , Covid-19 Anxiety Questionnaire, quality of work life and Rhoten fatigue questionnaires were used.Results: The results showed that the quality of life in both groups decreased and fatigue and anxiety caused by Covid-19 increased, but there was no statistically significant difference between anxiety derived fatigues of personnel involved with Covid-19 with personnel of other wards which were no directly faced Covid-19 patients. Regarding the quality of work life, no significant difference was observed in other components except in the component of human resource development. The results also showed that there was a statistically significant relationship between the level of anxiety caused by Covid-19 with quality of work life and fatigue.Conclusion: According to the results of the present study, Covid-19 had a negative effect on physical, mental and various aspects of quality of life of health care staff and led to increased fatigue and burnout, resulting in absence from work and its consequences.
Dedifferentiated Liposarcoma of Sigmoid Colon: A Case Report
Authors: Mei Xuepeng , Chen Xiaobin , Fan Haining , Wang Zhixin , Chen Yichong , Wang Haijiu , Zhou Ying
Published: September 2020

BACKGROUND: Primary liposarcoma of the colon with obstruction is a rare tumor, and patients with dedifferentiated liposarcoma of the sigmoid colon have not been reported in Pubmed for decades.CASE PRESENTATION: We reported that a 75-year-old female patient was admitted to the hospital due to abdominal pain and bloating. The imaging examination revealed that the sigmoid colon liposarcoma was considered malignant. She was treated with pelvic mass resection + partial colectomy + intestinal fistula. Postoperative pathological immunohistochemical prompts Differentiated sigmoid colon liposarcoma.CONCLUSIONS: We reported a rare case of dedifferentiated liposarcoma of the sigmoid colon, which is easily confused with atypical lipomatous tumors. Through this case, we hope to provide a reference for the diagnosis and treatment of dedifferentiated liposarcoma of the sigmoid colon.
Groundwater Potential Assessment Using Geoelectrical Data: A Case Study Of Phuket Island, Thailand
Authors: Puttiwongrak Avirut , Men Ratha , Suteerasak Thongchai , Vann Sakanann
Published: September 2020

Groundwater is the dominant source of water supply on Phuket island, Thailand. The water demand on Phuket has been increasing due to rapid urbanization and population growth. A scarcity of freshwater and over-extraction of groundwater may shortly become severe problems for Phuket. Geoelectrical data obtained by Vertical Electric Sounding (VES) were employed in this study to estimate the Dar Zarrouk parameters of the study area. Twenty-four VES stations were set up using Schlumberger configuration with a 1.0 m minimum spacing. The lithology layers from 24 unpublished borehole data indicating each subsurface layer were validated with the resistivity data obtained from VES. The geoelectric profiles gave a maximum of three layers with varying resistivities and thicknesses across each VES station. Two parameters (longitudinal conductance and transverse resistance) of the Dar Zarrouk model were calculated from VES data to generate the thematic maps in a GIS environment, thus the groundwater potential in Phuket Island was represented as a single map by using the weighted overlay technique in ArcGIS, based on both longitudinal conductance and transverse resistance. The groundwater potentials were classified into three potential levels (low, medium, and high). The results reveal that the highest groundwater potential areas are isolated and in specific locations, while the majority of area has medium level groundwater potential. Finally, the low potential zones are in the flank and the top parts of the study area.
Low NOX1 Expression in The Cytoplasm of GISTs Correlates With Poor Prognosis
Authors: Wang Wei , You Wenjun , Huang Fang , He Xin , Yuan Ao , Zhu Huijun
Published: September 2020

Objective: To investigate the expression effect and biological significance of NADPH oxidase l (NOX1) on the growth of human Gastrointestinal stromal tumor (GIST) at a protein level and the correlation between its expression level and patient prognosis.Methods: We enrolled a total of 146 patients confirmed by histopathology to be GIST tumors. Immunohistochemistry(IHC) analysis with GIST tissue microarray was used to assess NOXl level. The relativity study between NOXl expression level and GIST patient prognosis was evaluated. NOX1 mRNA expression was subsequently demonstrated using online database Oncomine.Results: Significance association with mitotic index (χ2 = 9.476, p = 0.009) and grade (χ2 = 11.392, p =0.010) was observed for low NOX1 cytoplasm staining of GIST cells and poor performance status in 78 of 146 (53.42%) GIST tissues, while for GIST patients with high expression of NOX1, there was no significant survival difference in disease progression. By univariate analysis, prognosis of GIST patients for overall survival (OS) rates were significantly positively correlated with NOX1 expression level (c2=2.429, p=0.014), tumor diameter (c2=2.048, p=0.004), mitotic index (c2=2.665, p<0.001), and grade (c2=3.162, p=0.001). Moreover, multivariate analyses demonstrated that low cytoplasm expression of NOX1 (c2=2.144, p=0.046) and mitotic index (c2=2.513, p=0.001) were striking related with OS rates, the difference was statistically significant. Kaplan-Meier survival curves further exhibited that low NOX1 cytoplasm expression and advanced mitotic index had a more unfavorable prognosis in GIST patients.Conclusion: These conclusions indicate that the degree of malignancy of GIST patients is closely related to NOX1 cytoplasm expression and mitotic index, both of which may be taken as an important role in the occurrence and development of GIST. It may act as an unfavorable predictive marker, indicating a new approach of gene therapy for GIST.
Assessing COVID-19 related anxiety among nurses in Malawi
Authors: Chorwe-Sungani Genesis
Published: September 2020

Introduction: Psychological wellbeing of nurses is crucial for them to effectively discharge their duties. However, COVID-19 related anxiety can interfere with nurses’ performance in their duties and reduce their self-efficacy levels.Aim: This study aimed at assessing COVID-19 related anxiety among nurses in Malawi.Method: This was a cross-sectional study that collected data from 102 nurses online. Data were analysed using descriptive statistics and receiver operating curve analysis.Results: This study found that 25.5% (n=26) of respondents had COVID-19 related anxiety and 48% (n=49) functional impairment. There were significant differences in the numbers of respondents who had functional impairment in relation to workplace (χ2=8.7, p= 0.03) with many of those working in hospitals (58.6%, n=34) having highest levels (Mean =20.6±10.4). The Coronavirus Anxiety Scale proved to be an effective instrument (Sensitivity=73.1%; Specificity=60.5%; AUC=0.73) for assessing COVID-19 related anxiety among nurses.Discussion: Prevalence of COVID-19 related anxiety is high among nurses and many of them experience functional impairment. The CAS should be used in clinical practice for detecting COVID-19 related anxiety among nurses.Implications for practiceNurses should be screened of COVID-19 related anxiety using valid instrument. Psychosocial interventions should be part of preparedness to reduce COVID-19 impact on nurses.
Imagenología aplicada a las momias de Tlayacapan, Morelos, México
Authors: Ruiz-González Judith L. , Serrano Sánchez Carlos
Published: September 2020

Las momias de Tlayacapan, Morelos, de inicios del siglo XIX, representan un sector de la élite del poblado y quizá el más vulnerable, por tratarse en su mayoría de infantes. A través del análisis imagenológico realizado en ellas, se pudo concluir que el estatus social de las momias de Tlayacapan no garantizó la sobrevivencia a edades mayores de los individuos momificados; aún para la gente acomodada del lugar fue difícil contrarrestar la mortalidad a ciertas edades de la vida, sobre todo en un periodo crítico en la ontogenia humana. En el siglo XIX se hace referencia constante de la muerte infantil, debida a enfermedades mortales que inciden durante los primeros años de vida postnatal. Este trabajo contribuye al conocimiento sobre las condiciones y estilo de vida que imperaba hacia finales del periodo novohispano, en uno de los poblados aledaños a la Ciudad de México.
Eventos comunicativos interculturales: la reflexividad sociolingüística en el discurso público sobre las diferencias
Authors: Ortega Rodríguez Emma Hilda
Published: September 2020

El presente artículo muestra el tratamiento discursivo que el gobierno mexicano ha conferido al tema de la diversidad cultural y lingüística del país a través de un dispositivo comunicativo propuesto aquí como evento comunicativo intercultural: un arreglo pragmático que cobró auge particularmente en la Ciudad de México durante 2010 y 2012, en el marco del Bicentenario de la independencia y revolución mexicanas, y caracterizado por mantener como eje temático la reivindicación política de las múltiples identidades nacionales a través de formulaciones argumentativas tendientes a una posible coyuntura política. La investigación se sustenta en un enfoque metodológico que vincula dos propuestas teóricas: la etnografía del habla, una perspectiva antropológica casi olvidada para delinear el contexto de una interacción comunicativa; y la reflexividad sociolingüística, paradigma reciente de base filosófica y sociológica, el cual permite concebir al discurso metalingüístico como mecanismo regulativo de permanencia y adscripción cultural. De este modo, los resultados obtenidos enlazan dos niveles de análisis: 1) el arreglo pragmático en donde emerge la naturaleza intercultural de sus participantes, funciones e intenciones discursivas; y 2) los contenidos temáticos emanados de dichas interacciones. Ambos productos, en conjunto, muestran un fenómeno poco señalado por los estudiosos de la interculturalidad, y es que diacrónica y sincrónicamente el discurso público sobre las diferencias no ha mantenido un ánimo unificador hacia la ciudadanía mexicana; por el contrario, ha mostrado compromisos sin cumplir, acuerdos sin ratificar y demandas sin un adecuado seguimiento a manos de quienes participan, a todo nivel jerárquico, de estos encuentros. La conclusión general de ello es que los llamados eventos comunicativos interculturales funcionan como un mecanismo simbólico de contención ante posibles conflictos sociales de ímpetu cultural y con efectos políticos a largo plazo.
Editorial
Authors: Martínez Dueñas William A.
Published: September 2020

En este número damos continuidad al dossier “contribuciones actuales a la bioantropología latinoamericana y del caribe” liderado por el bioantropólogo Miguel Eduardo Delgado (ver editoriales del volumen 18, número 3) (Delgado, 2019; Martínez-Dueñas, 2019). Presentamos cinco contribuciones más, provenientes de equipos de investigación de Argentina, Colombia y México que nos hablan de paleodieta en cazadores recolectores en Colombia, así mismo se aborda de manera general el desarrollo de la bioantropología en este país y sus retos actuales. Se reporta la organización y utilización en formación e investigación, de colecciones osteológicas en Argentina y Colombia. También se presenta un estudio histórico y paleopatológico de momias del siglo XVI en México, ofreciéndonos una aproximación a las dinámicas bioculturales de la época.
Organizmy pożyteczne w strategiach biologicznego zwalczania – grzyby owadobójcze
Authors: Augustyniuk-Kram Anna
Published: September 2020

Fungal entomopathogens are widespread in nature and contribute to the natural regulation of insects. They can be exploited for pest management as biological control agents of pests in attempts to improve the sustainability of crop protection. Four types of biological control are recognized: classical, inoculation, inundation, and conservation biological control. Classical biological control is the intentional introduction and permanent establishment of an exotic biological agent for long-term pest management. Inoculation biological control is the intentional release of a living organism as a biological control agent with the expectation that it will multiply and control the pest for an extended period, but not permanently. Inundation biological control is the release of large numbers of mass-produced biological control agents to reduce a pest population without necessarily achieving continuing impact or establishment. Conservation biological control is a modification of the environment or existing practices to protect and enhance specific natural enemies or other organisms to reduce the effect of pests. The traditional and the most popular approach in biological control with entomopathogenic fungi has been to apply the fungal material to the cropping system (as biopesticide), using an inundation biological control strategy. The term biopesticide is used for microbial biological pest control agents that are applied in a similar manner to chemical pesticides. The use of biopesticides can substitute for some (but not all) chemicals and provide environmentally safe and sustainable control of pests but EU legislation and prohibitive registration costs are discouraging the development and commercialization of many promising new products.
Dopuszczalność kary śmierci w ujęciu Tadeusza Ślipki. Kara śmierci rekapitulacją uprawnionej obrony
Authors: Butowski Krzysztof
Published: September 2020

The above article presents a critical analysis of a conception of limited admissibility of death penalty by Tadeusz Ślipko (restrained retention). Its essence is based on the fact that the victim of a wrongful aggressor has got the right to effectively defend his/her life. The source of such law lies in the absolute inviolability of innocent human’s life as a fundamental right of every man. In case of efficient act of aggression (cold – blooded murder), the state takes over the right to effectively defend the victim’s right of life by administering the perpetrator the death penalty (“life for life”).
Postulat czwartej generacji praw człowieka w politycznym systemie międzynarodowej ochrony – próba filozoficznego uzasadnienia z perspektywy personalizmu etycznego
Authors: Ciszek Mariusz
Published: September 2020

In my article, I presented conception of the fourth generation worked out by Catholic ethics. Mentioned conception according to Catholic ethics should be the law’s standard in the international system of protection of human rights. I tried to explain a sense of this conception from the philosophy perspective linking to the basic law’s acts.
Zadania administracji publicznej w zakresie gospodarki odpadami w Polsce
Authors: Jabłoński Maciej
Published: September 2020

The act on waste defines the rule of conduct with waste into the way protecting the life and the health of people and the environmental protection according to the principle of the sustainable development, in particular, the principle of prevention for coming into existence of waste or limiting the quantity of waste and their negative environmental impact, as well as therecycling or neutralizing of waste.
Od humanizmu ekologicznego i ekofilozofii do ekoteologii. Krytyka koncepcji duchowości ekologicznej H. Skolimowskiego
Authors: Czekalski Rafał
Published: September 2020

The purpose of this article was a review of the concept of ecological spirituality. Prior to this, however, the development of ecophilosophical thought of prof. Skolimowski has been presented. The starting point for Skolimowski’s philosophical thought is the holistic picture of the world (cosmology), which becomes the basis for the formulation of new ethics whose main attitude is reverence for the world and the man immersed in it. It is undoubtedly an original idea, opposing the canons and the paradigms valid in modern science. Skolimowski offers a holistic view of our civilization, the restoration of lost values, and inhibition of unilateral, i.e. materialistic progress. It is amazing how multifaceted Skolimowski’s publications are, ranging from strictly philosophical texts, regarding for instance analytical philosophy, to works concerning religious or social issues. The review of Skolimowski’s eco-theology has been conducted from the perspective of Catholic theology. The concept of God, spirituality, and the random treatment of other religions presented by Skolimowski are unacceptable. In reality, it is an attempt to subordinate religion to the assumptions of his own ecophilosophy.
Miejsce oceny cyklu życia w systemie zarządzania środowiskowego
Authors: Samson-Bręk Izabela , Filip Aleksandra
Published: September 2020

This publication was presented characteristics of the environmental life cycle assessment LCA (Life Cycle Assessment) as one of the methods included in the environmental management system (EMAS). Discusses also the various stages of analysis and guidance on the principles of its preparation regulated by the ISO 14000 standards (International Organization for Standardization), as well as paid attention to the key elements which determine the outcome of the assessments.
Ochrona środowiska przez administrację publiczną w gospodarce morskiej
Authors: Jabłoński Maciej
Published: September 2020

The maritime economy is a field that has a significant impact on the functioning of the entire global economy. Therefore, it is important to comply with high standards of environmental protection, which must be implemented in an effective way by public administrative bodies. Only in this way can the principle of the responsibility for entering into marine environment pollutants be implemented.