bluuebunny/crossref_metadata_2025 huggingface dataset:
H2S and homocysteine control a novel feedback regulation of cystathionine beta synthase and cystathionine gamma lyase in cardiomyocytes
Authors: Nandi Shyam Sundar , Mishra Paras Kumar
Published: June 2017

Hydrogen sulfide (H2S), a cardioprotective gas, is endogenously produced from homocysteine by cystathionine beta synthase (CBS) and cystathionine gamma lyase (CSE) enzymes. However, effect of H2S or homocysteine on CBS and CSE expression, and cross-talk between CBS and CSE are unclear. We hypothesize that homocysteine and H2S regulate CBS and CSE expressions in a dose dependent manner in cardiomyocytes, and CBS deficiency induces cardiac CSE expression. To test the hypothesis, we treated murine atrial HL1 cardiomyocytes with increasing doses of homocysteine or Na2S/GYY4137, a H2S donor, and measured the levels of CBS and CSE. We found that homocysteine upregulates CSE but downregulates CBS whereas Na2S/GYY4137 downregulates CSE but upregulates CBS in a dose-dependent manner. Moreover, the Na2S-treatment downregulates specificity protein-1 (SP1), an inducer for CSE, and upregulates miR-133a that targets SP1 and inhibits cardiomyocytes hypertrophy. Conversely, in the homocysteine-treated cardiomyocytes, CBS and miR-133a were downregulated and hypertrophy was induced. In vivo studies using CBS+/−, a model for hyperhomocysteinemia, and sibling CBS+/+ control mice revealed that deficiency of CBS upregulates cardiac CSE, plausibly by inducing SP1. In conclusion, we revealed a novel mechanism for H2S-mediated regulation of homocysteine metabolism in cardiomyocytes, and a negative feedback regulation between CBS and CSE in the heart.
Clinical Features and Sleep Analysis of Chinese Patients with Fatal Familial Insomnia
Authors: Wu Liyong , Lu Hui , Wang Xianling , Liu Jia , Huang Chaoyang , Ye Jing , Li Cuijiang , Lu Jun , Wang Yuping , Jia Jianping , Zhan Shuqin
Published: June 2017

This study aimed to examine clinical features, sleep, abnormal sleep-wake transition and non-sleep disturbances as well as lab tests in Chinese fatal familial insomnia (FFI) subjects. Patients with confirmed clinical and laboratory diagnosis of FFI have been retrospectively reviewed. The clinical features and the results of the complementary tests, including polysomnography (PSG), brain imaging and genetic analysis, were used. Two male and three female patients were recruited in this study. Three of the five patients had more comprehensive family medical records. The most typical clinical manifestations in all 5 patients were sleep disturbances, including insomnia, laryngeal stridor, sleep breath disturbance, and sleep-related involuntary movements. PSG of all these five cases showed reduction in total sleep time, sleep fragmentation, abnormal short non-rapid eye movement - rapid eye movement (REM) cycling, REM sleep reduction or loss, and REM sleep instruction in wakefulness. Patient 2's emission tomography scan demonstrated a reduction in glucose uptake in the left thalamus and bilateral inferior parietal lobe. In summary, Chinese FFI patients are typically characterized by organic sleep related symptoms, rapidly progressive dementia and sympathetic symptoms. We propose that structural damages in the thalamus and cortex are mostly responsible for clinical manifestations of FFI.
Ab initio molecular dynamics simulation of low energy radiation responses of α-Al2O3
Authors: Yuan Y. G. , Jiang M. , Zhao F. A. , Chen H. , Gao H. , Xiao H. Y. , Xiang X. , Zu X. T.
Published: June 2017

In this study, an ab initio molecular dynamics method is employed to investigate the response behavior of α-Al2O3 to low energy irradiation. Different from the previous experiments, our calculations reveal that the displacements of oxygen dominate under electron irradiation and the created defects are mainly oxygen vacancy and interstitial. The experimental observation of the absorption peaks appearing at 203, 233 and 256 nm for α-Al2O3 under electron irradiations should be contributed by the oxygen defects and these defects will reduce the transmittance of α-Al2O3, which agrees well with the very recent experiment. This study demonstrates the necessity to reinvestigate the threshold displacement energies of α-Al2O3, and to introduce recombination center for oxygen defects to improve its optical properties and performance under radiation environment.
Integration of DNA methylation and gene transcription across nineteen cell types reveals cell type-specific and genomic region-dependent regulatory patterns
Authors: Tang Binhua , Zhou Yufan , Wang Chiou-Miin , Huang Tim H.-M. , Jin Victor X.
Published: June 2017

Despite numerous studies done on understanding the role of DNA methylation, limited work has focused on systems integration of cell type-specific interplay between DNA methylation and gene transcription. Through a genome-wide analysis of DNA methylation across 19 cell types with T-47D as reference, we identified 106,252 cell type-specific differentially-methylated CpGs categorized into 7,537 differentially (46.6% hyper- and 53.4% hypo-) methylated regions. We found 44% promoter regions and 75% CpG islands were T-47D cell type-specific methylated. Pyrosequencing experiments validated the cell type-specific methylation across three benchmark cell lines. Interestingly, these DMRs overlapped with 1,145 known tumor suppressor genes. We then developed a Bayesian Gaussian Regression model to measure the relationship among DNA methylation, genomic segment distribution, differential gene expression and tumor suppressor gene status. The model uncovered that 3′UTR methylation has much less impact on transcriptional activity than other regions. Integration of DNA methylation and 82 transcription factor binding information across the 19 cell types suggested diverse interplay patterns between the two regulators. Our integrative analysis reveals cell type-specific and genomic region-dependent regulatory patterns and provides a perspective for integrating hundreds of various omics-seq data together.
Design for Fe-high Mn alloy with an improved combination of strength and ductility
Authors: Lee Seung-Joon , Han Jeongho , Lee Sukjin , Kang Seok-Hyeon , Lee Sang-Min , Lee Young-Kook
Published: June 2017

Recently, Fe-Mn twinning-induced plasticity steels with an austenite phase have been the course of great interest due to their excellent combination of tensile strength and ductility, which carbon steels have never been able to attain. Nevertheless, twinning-induced plasticity steels also exhibit a trade-off between strength and ductility, a longstanding dilemma for physical metallurgists, when fabricated based on the two alloy design parameters of stacking fault energy and grain size. Therefore, we investigated the tensile properties of three Fe-Mn austenitic steels with similar stacking fault energy and grain size, but different carbon concentrations. Surprisingly, when carbon concentration increased, both strength and ductility significantly improved. This indicates that the addition of carbon resulted in a proportionality between strength and ductility, instead of a trade-off between those characteristics. This new design parameter, C concentration, should be considered as a design parameter to endow Fe-Mn twinning-induced plasticity steel with a better combination of strength and ductility.
Characterization of an iron oxide nanoparticle labelling and MRI-based protocol for inducing human mesenchymal stem cells into neural-like cells
Authors: Lu Chen-Wen , Hsiao Jong-Kai , Liu Hon-Man , Wu Chung-Hsin
Published: June 2017

The aim of the current study was to develop an iron oxide nanoparticle (ION) labelling and magnetic resonance imaging (MRI)-based protocol to allow visualization of the differentiation process of mesenchymal stem cells (MSCs) into neural-like cells (NCs) in vitro. Ferucarbotran, a clinically available ION, which can be visualized under MRI, is used for tracking cells implanted in vivo. The NCs were verified morphologically and histologically by light microscopy, and their functions were verified by measuring their action potentials. Conformational conversion of axon-like structures was observed under light microscopy. These NCs exhibited frequent, active action potentials compared with cells that did not undergo neural differentiation. The labelling of ION had no influence on the morphological and functional differentiation capacity of the MSCs. We conclude that the MSCs that were differentiated into NCs exhibited in vitro activity potential firing and may be used to replace damaged neurons.
Analysis of Müller glia specific genes and their histone modification using Hes1-promoter driven EGFP expressing mouse
Authors: Ueno Kazuko , Iwagawa Toshiro , Ochiai Genki , Koso Hideto , Nakauchi Hiromitsu , Nagasaki Masao , Suzuki Yutaka , Watanabe Sumiko
Published: June 2017

Retinal neurons and Müller glia are generated from a common population of multipotent retinal progenitor cells. We purposed to identify Müller glia-specific molecular signatures during retinal development. Using transgenic mice carrying the Hes1 promoter (pHes1) followed by EGFP, we purified EGFP-positive Müller glia and other EGFP-negative retinal cells from developing retinas and subjected them to RNA sequencing analysis. Gene expression pattern of EGFP-positive cell was similar to genes expressed in retinal progenitors, and they were downregulated in other cell lineages. Then, we examined the modification profiles of H3K27me3 and H3K4me3 by referring to chromatin immunoprecipitation-sequencing data of rods and other cells. Clustering of the H3K4me3 and H3K27me3 values followed by ontology analysis revealed a high incidence of transcription factors including Hes1 in clusters with high H3K27me3 levels. Hes1 expression level decreased dramatically, and the H3K27me3 level at the Hes1-locus was upregulated strongly during retinal development. Furthermore, the Hes1 expression level was upregulated in an Ezh2-knockout retina. These results suggest that downregulation of Müller glia-related genes in other lineage rather than upregulation of them in Müller glia contributed Müller-specific molecular features, and a role for modified H3K27me3 in suppressing Müller glia-related genes in other retinal cell lineages to avoid unfavorable expression.
Ascorbate induces apoptosis in melanoma cells by suppressing Clusterin expression
Authors: Mustafi Sushmita , Sant David W. , Liu Zhao-Jun , Wang Gaofeng
Published: June 2017

Pharmacological levels of ascorbate have long been suggested as a potential treatment of cancer. However, we observed that EC50 of ascorbate was at a similar level for cultured healthy melanocytes and melanoma cells, suggesting a limit of pharmacological ascorbate in treating cancer. Loss of 5-hydroxymethylcytosine (5 hmC) is an epigenetic hallmark of cancer and ascorbate promotes 5 hmC generation by serving as a cofactor for TET methylcytosine dioxygenases. Our previous work demonstrated that ascorbate treatment at physiological level (100 μM) increased 5 hmC content in melanoma cells toward the level of healthy melanocytes. Here we show that 100 µM of ascorbate induced apoptosis in A2058 melanoma cells. RNA-seq analysis revealed that expression of the Clusterin (CLU) gene, which is related to apoptosis, was downregulated by ascorbate. The suppression of CLU was verified at transcript level in different melanoma cell lines, and at protein level in A2058 cells. The anti-apoptotic cytoplasmic CLU was decreased, while the pro-apoptotic nuclear CLU was largely maintained, after ascorbate treatment. These changes in CLU subcellular localization were also associated with Bax and caspases activation, Bcl-xL sequestration, and cytochrome c release. Taken together, this study establishes an impending therapeutic role of physiological ascorbate to potentiate apoptosis in melanoma.
Prognostic value of olfactory nerve damage measured with thallium-based olfactory imaging in patients with idiopathic olfactory dysfunction
Authors: Shiga Hideaki , Taki Junichi , Okuda Koichi , Watanabe Naoto , Tonami Hisao , Nakagawa Hideaki , Kinuya Seigo , Miwa Takaki
Published: June 2017

Idiopathic olfactory disorder is resistant to treatment, and the recovery time is long. This study investigated the prognostic value of the migration of nasally administered thallium-201 to the olfactory bulb (thallium migration to the OB), a measure of olfactory nerve damage, in patients with idiopathic olfactory disorders. Twenty-four patients with idiopathic olfactory disorders were enrolled in the study (7 women and 17 men; aged 23–73 years). We retrospectively analyzed potential prognostic markers in subjects who underwent thallium-based olfactory imaging with the nasal administration of thallium-201 before conventional treatment with the Japanese herbal medicine tokishakuyakusan and compared those data with the prognosis. Log-rank tests were performed to assess the relationship between thallium migration to the OB (<4.6% [low] vs. ≥4.6% [high]; data dichotomized at the optimal cutoff value) and the duration until recovery of the odor recognition threshold determined by a standard olfactory function test (T&T olfactometry) after the treatment. Upon statistical analysis, we found that high thallium migration to the OB was significantly correlated with better prognosis in patients. Our results suggest that patients with intact olfactory nerve fibers could be selected using thallium-based imaging for the long-term follow-up of olfactory dysfunction.
A non-ionotropic activity of NMDA receptors contributes to glycine-induced neuroprotection in cerebral ischemia-reperfusion injury
Authors: Chen Juan , Hu Rong , Liao Huabao , Zhang Ya , Lei Ruixue , Zhang Zhifeng , Zhuang Yang , Wan Yu , Jin Ping , Feng Hua , Wan Qi
Published: June 2017

NMDA receptor (NMDAR) is known for its ionotropic function. But recent evidence suggests that NMDAR also has a non-ionotropic property. To determine the role of non-ionotropic activity of NMDARs in clinical relevant conditions, we tested the effect of glycine, a co-agonist of NMDARs, in rat middle cerebral artery occlusion (MCAO), an animal model of cerebral ischemia-reperfusion injury after the animals were injected with the NMDAR channel blocker MK-801 and the glycine receptor antagonist strychnine. We show that glycine reduces the infarct volume in the brain of ischemic stroke animals pre-injected with MK-801 and strychnine. The effect of glycine is sensitive to the antagonist of glycine-GluN1 binding site and blocked by Akt inhibition. In the neurobehavioral tests, glycine improves the functional recovery of stroke animals pre-injected with MK-801 and strychnine. This study suggests that glycine-induced neuroprotection is mediated in part by the non-ionotropic activity of NMDARs via Akt activation in cerebral ischemia-reperfusion injury.
Chinese Milk Vetch Improves Plant Growth, Development and 15N Recovery in the Rice-Based Rotation System of South China
Authors: Xie Zhijian , He Yaqin , Tu Shuxin , Xu Changxu , Liu Guangrong , Wang Huimin , Cao Weidong , Liu Hui
Published: June 2017

Chinese milk vetch (CMV) is vital for agriculture and environment in China. A pot experiment combined with 15N labeling (including three treatments: control, no fertilizer N and CMV; 15N-labeled urea alone, 15NU; substituting partial 15NU with CMV, 15NU-M) was conducted to evaluate the impact of CMV on plant growth, development and 15NU recovery in rice-based rotation system. The 15NU-M mitigated oxidative damage by increasing antioxidant enzymes activities and chlorophyll content while decreased malondialdehyde content in rice root and shoot, increased the biomass, total N and 15N uptake of plant shoots by 8%, 12% and 39% respectively, thus inducing a noticeable increase of annual 15N recovery by 77% versus 15NU alone. Remarkable increases in soil NH4+ and populations of bacteria, actinomycetes and azotobacter were obtained in legume-rice rotation system while an adverse result was observed in soil NO3− content versus fallow-rice. CMV as green manure significantly increased the fungal population which was decreased with cultivating CMV as cover crop. Therefore, including legume cover crop in rice-based rotation system improves plant growth and development, annual N conservation and recovery probably by altering soil nitrogen forms plus ameliorating soil microbial communities and antioxidant system which alleviates oxidative damages in plants.
Designing a molecular magnetic button based on 4d and 5d transition-metal phthalocyanines
Authors: Ferriani P. , Heinze S. , Bellini V.
Published: June 2017

The field of molecular spintronics exploits the properties of organic molecules possessing a magnetic moment, either native in the form of radicals or induced by the insertion of transition metal magnetic ions. To realize logic or storage molecular spin-tronics devices, molecules with stable different magnetic states should be deposited on a substrate, and switching between the states controllably achieved. By means of a first-principles calculations, we have devised a functional molecule exhibiting different magnetic states upon structural changes induced by current injection. We investigate the prototypical case of non-planar M-Phthalocyanine (MPc), where M is a transition-metal ion belonging to the 4d and 5d series. We find that for ZrPc and HfPc deposited on a graphene decorated Ni(111) substrate, two different structural conformations could be stabilized, for which the molecules attain different magnetic states depending on the position of the M ion – whether above the Pc or between the Pc and the substrate –, acting therefore as molecular magnetic button. Our work indicates an intuitive way to engineer a magnetic molecular switch with tailored properties, starting from the knowledge of the basic atomic properties of elements and surfaces.
Improved Growth Patterns in Cystic Fibrosis Mice after Loss of Histone Deacetylase 6
Authors: Rymut Sharon M. , Corey Deborah A. , Valerio Dana M. , Erokwu Bernadette O. , Flask Chris A. , Kelley Thomas J. , Hodges Craig A.
Published: June 2017

Growth failure in cystic fibrosis (CF) patients has been well-documented and shown to correlate with poorer disease outcomes. This observation is also true in CF animal models, including mouse, pig, rat, and ferret. The etiology underlying growth deficits is unknown, and our previous work demonstrated reduced tubulin acetylation in CF cell models and tissue that is correctable by inhibition of histone deacetylase-6 (HDAC6). Here, we hypothesize that loss of HDAC6 will improve growth phenotype in a CF mouse model. Hdac6 knockout mice were crossed with F508del (CF) mice to generate F508del/Hdac6 (CF/HDA) mice. Growth, fat deposits, survival, and bioelectric measurements were analyzed. CF/HDA mice displayed improvements in length and weight with no correction of CFTR function. Mechanistically, Igf1 levels likely account for increased length and improvements in fertility. Weight gain is attributed to increased fat deposits potentially mediated by increased adipocyte differentiation. CF-related growth deficits can be improved via inhibition of HDAC6, further implicating it as a potential therapeutic target for CF.
Dengue virus activates cGAS through the release of mitochondrial DNA
Authors: Sun Bo , Sundström Karin B. , Chew Jun Jie , Bist Pradeep , Gan Esther S. , Tan Hwee Cheng , Goh Kenneth C. , Chawla Tanu , Tang Choon Kit , Ooi Eng Eong
Published: June 2017

Cyclic GMP-AMP synthetase (cGAS) is a DNA-specific cytosolic sensor, which detects and initiates host defense responses against microbial DNA. It is thus curious that a recent study identified cGAS as playing important roles in inhibiting positive-sense single-stranded RNA (+ssRNA) viral infection, especially since RNA is not known to activate cGAS. Using a dengue virus serotype 2 (DENV-2) vaccine strain (PDK53), we show that infection creates an endogenous source of cytosolic DNA in infected cells through the release of mitochondrial DNA (mtDNA) to drive the production of cGAMP by cGAS. Innate immune responses triggered by cGAMP contribute to limiting the spread of DENV to adjacent uninfected cells through contact dependent gap junctions. Our result thus supports the notion that RNA virus indirectly activates a DNA-specific innate immune signaling pathway and highlights the breadth of the cGAS-induced antiviral response.
Salivary testosterone measurement in women with and without polycystic ovary syndrome
Authors: Sathyapalan Thozhukat , Al-Qaissi Ahmed , Kilpatrick Eric S. , Dargham Soha R. , Adaway Joanne , Keevil Brian , Atkin Stephen L.
Published: June 2017

Clinical and/or biochemical hyperandrogenism is one of the diagnostic criteria for PCOS. An evaluation of the role of salivary testosterone (salT) and androstenedione (salA) for the diagnosis of PCOS was undertaken in a cross sectional study involving 65 women without PCOS and 110 women with PCOS fulfilling all 3 diagnostic Rotterdam criteria. Serum and salivary androgen measurements were determined by LC-MS/MS. salT and salA were significantly elevated in PCOS compared to controls (P < 001). No androgen marker was more predictive than another using ROC curves, but multiple logistic regression suggested salT was more predictive than free androgen index (FAI) (p < 0.01). The combination of salT or FAI identified 100% of PCOS women. PCOS women with both biochemical and clinical hyperandrogenism as opposed to clinical hyperandrogenism alone showed a metabolic phenotype (p < 0.05) and insulin resistance (p < 0.001). PCOS patients with an isolated elevated FAI showed increased insulin resistance compared to those with an isolated salT (P < 0.05). salT appeared to be at least as predictive as FAI for the diagnosis of the classical PCOS phenotype, and the combination of salT or FAI identified 100% of PCOS patients. This suggests that salT measurement by LC-MS/MS holds the promise of complementing existing laboratory tests as a means of assessing hyperandrogenemia.
Regulation of Angiopoietin Signalling by Soluble Tie2 Ectodomain and Engineered Ligand Trap
Authors: Alawo Deborah O. A. , Tahir Tariq A. , Fischer Marlies , Bates Declan G. , Amirova Svetlana R. , Brindle Nicholas P. J.
Published: June 2017

Angiopoietin-1 (Angpt1) is a glycoprotein ligand important for maintaining the vascular system. It signals via a receptor tyrosine kinase expressed on the surface on endothelial cells, Tie2. This receptor can undergo regulated ectodomain cleavage that releases the ligand-binding domain (sTie2) into the circulation. The concentration of sTie2 is increased in a range of conditions, including peripheral arterial disease and myocardial infarction, where it has been suggested to bind and block Angpt1 resulting in vascular dysfunction. Here we use a joint mathematical modelling and experimental approach to assess the potential impact of sTie2 on the ability of Angpt1 to signal. We find that the concentrations of sTie2 relative to Angpt1 required to suppress signalling by the ligand are more than ten–fold higher than those ever seen in normal or disease conditions. In contrast to the endogenous sTie2, an engineered form of sTie2, which presents dimeric ligand binding sites, inhibits Angpt1 signalling at seventy-fold lower concentrations. While loss of Tie2 ectodomain can suppress Angpt1 signalling locally in the cells in which the receptor is lost, our study shows that the resulting increase in circulating sTie2 is unlikely to affect Angpt1 activity elsewhere in the body.
Factors controlling the mechanical properties degradation and permeability of coal subjected to liquid nitrogen freeze-thaw
Authors: Qin Lei , Zhai Cheng , Liu Shimin , Xu Jizhao
Published: June 2017

Freeze-thaw induced fracturing coal by liquid nitrogen (LN2) injection exerts a significant positive effect on the fracture permeability enhancement of the coal reservoir. To evaluate the different freeze-thaw variables which modify the mechanical properties of treated coals, the effects of freezing time, number of freeze-thaw cycles, and the moisture content of coal were studied using combined uniaxial compression and acoustic emission testing systems. Freezing the samples with LN2 for increasing amounts of time degraded the strength of coal within a certain limit. Comparison to freezing time, freeze-thaw cycling caused much more damage to the coal strength. The third variable studied, freeze-thaw damage resulting from high moisture content, was restricted by the coal’s moisture saturation limit. Based on the experimental results, equations describing the amount of damage caused by each of the different freeze-thaw variables were empirically regressed. Additionally, by using the ultrasonic wave detection method and fractal dimension analyses, how freeze-thaw induced fractures in the coal was quantitatively analyzed. The results also showed that the velocity of ultrasonic waves had a negative correlation with coal permeability, and the freeze-thaw cycles significantly augment the permeability of frozen-thawed coal masses.
UV-induced damage to DNA: effect of cytosine methylation on pyrimidine dimerization
Authors: Martinez-Fernandez Lara , Banyasz Akos , Esposito Luciana , Markovitsi Dimitra , Improta Roberto
Published: June 2017

Methylation/demethylation of cytosine plays an important role in epigenetic signaling, the reversibility of epigenetic modifications offering important opportunities for targeted therapies. Actually, methylated sites have been correlated with mutational hotspots detected in skin cancers. The present brief review discusses the physicochemical parameters underlying the specific ultraviolet-induced reactivity of methylated cytosine. It focuses on dimerization reactions giving rise to cyclobutane pyrimidine dimers and pyrimidine (6–4) pyrimidone adducts. According to recent studies, four conformational and electronic factors that are affected by cytosine methylation may control these reactions: the red-shift of the absorption spectrum, the lengthening of the excited state lifetime, changes in the sugar puckering modifying the stacking between reactive pyrimidines and an increase in the rigidity of duplexes favoring excitation energy transfer toward methylated pyrimidines.
Kinetically modulated specificity against single-base mutants in nucleic acid recycling circuitry using the destabilization motif
Authors: Fan Tsz Wing , Hsing I-Ming
Published: June 2017

Signal amplification in nucleic acid sensing improves detection sensitivity, but difficulties remain in sustaining specificity over time, particularly under excess amounts of single-base mutants.
Beyond sulfide-centric catalysis: recent advances in the catalytic cyclization reactions of sulfur ylides
Authors: Lu Liang-Qiu , Li Tian-Ren , Wang Qiang , Xiao Wen-Jing
Published: June 2017

This Tutorial Review highlighted recent achievements on the catalytic cyclization reactions of sulfur ylide reagents, especially the asymmetric processes avoiding the use of structurally complex chiral sulfides.
Polymeric carbon nitride for solar hydrogen production
Authors: Li Xiaobo , Masters Anthony F. , Maschmeyer Thomas
Published: June 2017

The developments of polymeric carbon nitride in photocatalysis are reviewed focusing on the three primary processes of a photocatalytic reaction.
A new AIE multi-block polyurethane copolymer material for subcellular microfilament imaging in living cells
Authors: Niu Yu-qing , He Tao , Song Jun , Chen Si-ping , Liu Xiang-yu , Chen Zhi-gang , Yu Ying-jie , Chen Shi-guo
Published: June 2017

A multi-block fluorescent amphiphilic polyurethane copolymer (TPE-PU), self-assembling into hairy, water-soluble micelles, is used as a subcellular microfilament probe in living cells.
A hyaluronidase/temperature dual-responsive supramolecular assembly based on the anionic recognition of calixpyridinium
Authors: Wang Kui , Cui Jian-Hua , Xing Si-Yang , Ren Xiao-Wei
Published: June 2017

We constructed a supramolecular assembly based on the anionic recognition of calixpyridinium for the first time, which showed hyaluronidase/temperature dual-response.
Practical in situ-generation of phosphinite ligands for palladium-catalyzed carbonylation of (hetero)aryl bromides forming esters
Authors: Wang Lin , Neumann Helfried , Spannenberg Anke , Beller Matthias
Published: June 2017

An effective method for alkoxycarbonylation of (hetero)aryl bromides is developed in the presence of in situ-generated phosphinite ligands tBu2POR (R = nBu, nPr, Et or Me).
A biocatalytic and thermoreversible hydrogel from a histidine-containing tripeptide
Authors: Garcia A. M. , Kurbasic M. , Kralj S. , Melchionna M. , Marchesan S.
Published: June 2017

Minimalist biocatalyst: a thermoreversible hydrogel from an unprotected tripeptide bearing histidine.
Three-component reactions of isocyanoacetates, amines and 3-formylchromones initiated by an unexpected aza-Michael addition
Authors: Liao Jia-Yu , Yap Wei Jie , Wu Ji'En , Wong Ming Wah , Zhao Yu
Published: June 2017

We present herein a new mode of three-component reactions between isocyanoacetates, amines and 3-formylchromones. Mechanistic and DFT studies reveals that this Ag-catalyzed process is initiated by a facile aza-Michael addition.
Facile access to 2,2-disubstituted indolin-3-ones via a cascade Fischer indolization/Claisen rearrangement reaction
Authors: Xia Zilei , Hu Jiadong , Gao Yu-Qi , Yao Qizheng , Xie Weiqing
Published: June 2017

From readily accessible arylhydrazines and allyloxyketones, 2,2-disubstituted indolin-3-ones could be obtained in good to excellent yields via a cascade Fischer indolization/Claisen rearrangement process.
A modular synthesis approach to multinuclear heterometallic oxo clusters in polyoxometalates
Authors: Minato Takuo , Suzuki Kosuke , Ohata Yusuke , Yamaguchi Kazuya , Mizuno Noritaka
Published: June 2017

A “modular synthesis approach” to multinuclear heterometallic oxo clusters in lacunary polyoxometalates was successfully developed.
Quantifying the exchange coupling in linear copper porphyrin oligomers
Authors: Richert Sabine , Kuprov Ilya , Peeks Martin D. , Suturina Elizaveta A. , Cremers Jonathan , Anderson Harry L. , Timmel Christiane R.
Published: June 2017

The unique combination of EPR, DFT and novel large-scale simulation methods provides information on exchange coupling between metal centers in molecular wires.
Anisotropic longitudinal electronic relaxation affects DNP at cryogenic temperatures
Authors: Weber E. M. M. , Vezin H. , Kempf J. G. , Bodenhausen G. , Abergél D. , Kurzbach D.
Published: June 2017

Anisotropic longitudinal electronic relaxation in nitroxide radicals can impact DNP at low temperatures in cases of slow spectral diffusion.
Noninnocent ligands: heteroleptic nickel complexes with α-diimine and 1,2-diketone derivatives
Authors: Yang Hong , Zhao Yanxia , Liu Bin , Su Ji-Hu , Fedushkin Igor L. , Wu Biao , Yang Xiao-Juan
Published: June 2017

Heteroleptic nickel complexes that contain the noninnocent α-diimine and 1,2-diketone ligands were synthesized and their crystal and electronic structures were characterized.
Synthesis and characterization of rhenium(iii) complexes with (Ph2PCH2CH2)2NR diphosphinoamine ligands
Authors: Salvarese Nicola , Refosco Fiorenzo , Seraglia Roberta , Roverso Marco , Dolmella Alessandro , Bolzati Cristina
Published: June 2017

The reactivities of diphosphinoamine ligands [(Ph2PCH2CH2)2NR] toward rhenium(iii,v) precursors have been studied. The obtained complexes have been fully characterized.
Two-step FRET mediated metal ion induced signalling responses in a probe appended with three fluorophores
Authors: Biswal Biswonath , Pal Ajoy , Bag Bamaprasad
Published: June 2017

A tri-fluorophore appended Tren receptor based probe exhibited chelation induced ratiometric fluorescence signalling through a two-step FRET process; enhancement of FAn→ FRhenergy transfer efficiency through an FNBDintermediate was observed.
Correction: Platinum complexes as light promoted anticancer agents: a redefined strategy for controlled activation
Authors: Mitra Koushambi
Published: June 2017

Correction for ‘Platinum complexes as light promoted anticancer agents: a redefined strategy for controlled activation’ by Koushambi Mitra, et al., Dalton Trans., 2016, 45, 19157–19171.
Bioaccessibility and bioavailability of phenolic compounds in bread: a review
Authors: Angelino Donato , Cossu Marta , Marti Alessandra , Zanoletti Miriam , Chiavaroli Laura , Brighenti Furio , Del Rio Daniele , Martini Daniela
Published: June 2017

Cereal-based products, like breads, are a vehicle for bioactive compounds, including polyphenols.
Unveiling a VEGF-mimetic peptide sequence in the IQGAP1 protein
Authors: Capasso Domenica , Di Gaetano Sonia , Celentano Veronica , Diana Donatella , Festa Luisa , Di Stasi Rossella , De Rosa Lucia , Fattorusso Roberto , D'Andrea Luca D.
Published: June 2017

A peptide able to recapitulate the VEGF effect on ECs was derived from the IQGAP1 protein sequence.
Aggregation-induced emission enhancement and aggregation-induced circular dichroism of chiral pentaphenylpyrrole derivatives and their helical self-assembly
Authors: Zhang Longlong , Liang Kaichang , Dong Lichao , Yang Peipei , Li Yuanyuan , Feng Xiao , Zhi Junge , Shi Jianbing , Tong Bin , Dong Yuping
Published: June 2017

AIEE-active chiral pentaphenylpyrrole derivatives possess AICD and circularly polarized luminescence features with self-assembling to regular nanofibers.
Rational design, preparation and adsorption study of a magnetic molecularly imprinted polymer using a dummy template and a bifunctional monomer
Authors: Li Geyuan , Zhang Kai , Fizir Meriem , Niu Muchuan , Sun Cheng , Xi Shuangling , Hui Xuanhong , Shi Jianrong , He Hua
Published: June 2017

In this study, a molecular docking method and solvation model in computer simulation were applied to simultaneously screen a dummy template and a bifunctional monomer in the rational design of a magnetic molecularly imprinted polymer.
Preparation, characterization and catalytic application of nano-Fe3O4-DOPA-SnO2 having high TON and TOF for non-toxic and sustainable synthesis of dihydroquinazolinone derivatives
Authors: Dam Binoyargha , Patil Ranjit A. , Ma Yuan-Ron , Pal Amarta Kumar
Published: June 2017

A novel class of heterogeneous magnetically separable nano catalysts was designed by encapsulating SnO2 on nano-Fe3O4-DOPA. And is applied for the synthesis of dihydroquinazolinone derivatives.
The first electrochemical and surface analysis of 2-aminobenzimidazole as a corrosion inhibitor for copper in chloride solution
Authors: Xhanari Klodian , Finšgar Matjaž
Published: June 2017

High corrosion inhibition effectiveness of 2-aminobenzimidazole is proven after a long-term immersion period in 3 wt% NaCl solution.
Microwave-induced combustion: towards a robust and predictable sample preparation method
Authors: Schmidt Lucas , Bizzi Cezar A. , Rosa Francisco C. , Cruz Sandra M. , Barin Juliano S. , Flores Erico M. M.
Published: June 2017

Ideal gas equation was used as a tool for calculating the stoichiometric amount of O2 for efficient sample digestion using MIC method.
Controllable growth of Au@TiO2yolk–shell nanoparticles and their geometry parameter effects on photocatalytic activity
Authors: Sun Hang , He Qinrong , Zeng Shan , She Ping , Zhang Xiaochen , Li Jiayi , Liu Zhenning
Published: June 2017

The one-pot hydrothermal approach has been used to achieve Au@TiO2yolk–shell NPs with different geometry parameters: smaller cavities, thinner TiO2shells and medium Au cores facilitate more efficient photocatalysis.
Evidence of electric field-tunable tunneling probability in graphene and metal contact
Authors: Peng Songang , Jin Zhi , Zhang Dayong , Shi Jingyuan , Zhang Yanhui , Yu Guanghui
Published: June 2017

The tunneling probability in metal/graphene contact is not constant, but highly dependent on the Fermi level of graphene under the metal.
Coordination polymer nanoparticles from nucleotide and lanthanide ions as a versatile platform for color-tunable luminescence and integrating Boolean logic operations
Authors: Gao Ru-Ru , Shi Shuo , Li Yu-Jie , Wumaier Maierhaba , Hu Xiao-Chun , Yao Tian-Ming
Published: June 2017

Color-tunable luminescence, trichromatic white light and gate cascades have been realized based on the CPNs assembled from nucleotides and Ln3+.
Display of functional proteins on supramolecular peptide nanofibrils using a split-protein strategy
Authors: DiMaio John T. M. , Raymond Danielle M. , Nilsson Bradley L.
Published: June 2017

The display of functional proteins on self-assembled peptide nanofibrils is accomplished by noncovalent attachment using a split-protein strategy.
An unprecedented stereoselective base-induced trimerization of an α-bromovinylsulfone
Authors: Fisher Brendan , Lepage Romain J. , White Jonathan M. , Ye Young , Krenske Elizabeth H. , Rizzacasa Mark A.
Published: June 2017

A unprecedented base-induced trimerization of bromovinylsulfone 1 afforded the cyclohexene 6 as a single diastereoisomer.
N-Hydroxy sulfonamides as new sulfenylating agents for the functionalization of aromatic compounds
Authors: Wang Fu-Xiang , Zhou Shao-Da , Wang Chengming , Tian Shi-Kai
Published: June 2017

A conceptually new synthetic application of N-hydroxy sulfonamides has been established in the catalytic sulfenylation of aromatic compounds.
Customizing plasmonic diffraction patterns by laser interference
Authors: Peláez R. J. , Ferrero A. , Škereň M. , Bernad B. , Campos J.
Published: June 2017

This work reports a versatile and efficient production of periodic microstructures surrounded by metallic alloy nanoparticles supported on glass with customized visible diffraction patterns by using the technique of phase mask laser interference.
Silica template-assisted synthesis of SnO2@porous carbon composites as anode materials with excellent rate capability and cycling stability for lithium-ion batteries
Authors: Guo Jian , Li Ping , Chai Liying , Su Yi , Diao Jinxiang , Guo Xiaohui
Published: June 2017

A kind of porous carbon coated SnO2-based composites was successfully produced under direction of a silica template. The prepared SnO2@PC anodes deliver high specific capacity, excellent cycling durability and remarkable rate capability in LIBs.
Low thermal conductivity in Si/Ge hetero-twinned superlattices
Authors: Dong Huicong , Wen Bin , Zhang Yuwen , Melnik Roderick
Published: June 2017

Low thermal conductivity of Si/Ge hetero-twinned superlattice, in comparison with that of single crystal Si, twinned Si, Si/Ge alloy and conventional Si/Ge superlattice.
Gas detection based on quantum dot LEDs utilizing differential optical absorption spectroscopy
Authors: Yu Siyao , Yan Long , Zhang Tieqiang , Zhang Yu , Zhang Xiaoyu , Sun Guang , Yu William W.
Published: June 2017

Acetylene and ammonia detections were realized by employing PbSe QD-based LED and differential optical absorption spectroscopy.
A highly effective Ag–RANEY® nickel hybrid catalyst for reduction of nitrofurazone and aromatic nitro compounds in aqueous solution
Authors: Khorshidi Alireza , Ghorbannezhad Bahareh
Published: June 2017

RANEY® nickel reduced Ag+ ions to form ultrafine spherical silver nanoparticles over itself, and the obtained hybrid material was used as catalyst for efficient and selective reduction of nitro compounds, in aqueous solution by using NaBH4.
Hydrogenation/oxidation induced efficient reversible color switching between methylene blue and leuco-methylene blue
Authors: Liu Ya-Nan , Zhou Xiao , Wang Xin , Liang Kuang , Yang Zheng-Kun , Shen Cong-Cong , Imran M. , Sahar Shafaq , Xu An-Wu
Published: June 2017

A novel reversible color switching system based on one-pot hydrogenation/oxygenation reactions, and with excellent cycling performance and high switching rates as an oxygen indicator.
Graphene-decorated silica stabilized stearic acid as a thermal energy storage material
Authors: Li Chuanchang , Xie Baoshan , Chen Jian
Published: June 2017

Graphene-decorated silica stabilized stearic acid composites with interesting thermal energy storage behaviors.
Correction: Spatial control of direct chemical vapor deposition of graphene on silicon dioxide by directional copper dewetting
Authors: van den Beld Wesley T. E. , van den Berg Albert , Eijkel Jan C. T.
Published: June 2017

Correction for ‘Spatial control of direct chemical vapor deposition of graphene on silicon dioxide by directional copper dewetting’ by Wesley T. E. van den Beld et al., RSC Adv., 2016, 6, 89380–89386.
Rapid access to substituted 2-naphthyne intermediates via the benzannulation of halogenated silylalkynes
Authors: Hein Samuel J. , Lehnherr Dan , Dichtel William R.
Published: June 2017

A ZnCl2-catalyzed, regioselective benzannulation of halogenated silylacetylenes provides access to 2-naphthyne precursors.
H2/O2enzymatic fuel cells: from proof-of-concept to powerful devices
Authors: Mazurenko I. , Wang X. , de Poulpiquet A. , Lojou E.
Published: June 2017

H2/O2enzymatic fuel cells are sustainable devices for electricity generation that have undergone great developments during the last 5 years, thanks to the concomitant improvement of the involved enzymes,i.e.hydrogenases and bilirubin oxidase, and their immobilization procedure on electrodes.
Tensile force-induced tearing and collapse of ultrathin carbon shells to surface-wrinkled grape skins for high performance supercapacitor electrodes
Authors: Zhang Guofeng , Zhang Jing , Qin Qing , Cui Yingxue , Luo Wenhao , Sun Yan , Jin Cen , Zheng Wenjun
Published: June 2017

Mesoporous carbon nano grape skins have been fabricated via a facile hydrothermal method. The resulting carbon nano grape skins showed excellent performance when used as supercapacitor electrode.
Fluorescent carbon dots with tunable emission by dopamine for sensing of intracellular pH, elementary arithmetic operations and a living cell imaging based INHIBIT logic gate
Authors: Lan Chuanqing , Zhang Liangliang , Shi Bingfang , Chen Dongxia , Zhao Limin , Zhao Shulin
Published: June 2017

Luminescent carbon dots with tunable emission were prepared by the pyrolysis of citric acid and dopamine for sensing of intracellular pH, elementary arithmetic operations and a living cell imaging based INHIBIT logic gate.
A dual-channel optical magnetometer based on magnetically responsive inverse opal microspheres
Authors: Zhang Yuqi , Jiang Yitong , Wu Xiaojie , Ge Jianping
Published: June 2017

The chain assembly of inverse opal microspheres in a ferrofluid and their reflection quenching are used to detect magnetic field strength.
Stochastic optimal control problem with infinite horizon driven by G-Brownian motion
Authors: Hu Mingshang , Wang Falei
Published: June 2017

The present paper considers a stochastic optimal control problem, in which the cost function is defined through a backward stochastic differential equation with infinite horizon driven by G-Brownian motion. Then we study the regularities of the value function and establish the dynamic programming principle. Moreover, we prove that the value function is the unique viscosity solution of the related Hamilton−Jacobi−Bellman−Isaacs (HJBI) equation.
Efficacité des techniques de décortication alvéolaire sélective dans l’accélération du traitement orthodontique : une revue systématique de la littérature
Authors: Fau Victor , Diep Dany , Bader Gérard , Brézulier Damien , Sorel Olivier
Published: June 2017

Introduction : Les publications scientifiques concernant l’accélération du traitement orthodontique, et plus particulièrement les techniques chirurgicales de corticotomies alvéolaires ont vu leur nombre croître exponentiellement au cours de ces dernières années. L’objectif de cette revue systématique de la littérature était d’évaluer l’efficacité de ces corticotomies en se basant sur des études réalisées chez l’Homme. Matériel et méthode : La revue fut entreprise à partir des bases de données Medline et Web of Science Core Collection afin d’identifier les essais cliniques prospectifs contrôlés ayant pour critère de jugement principal la durée du traitement orthodontique ou la vitesse du déplacement dentaire. Résultats : Onze études répondaient à l’ensemble des critères d’inclusion. Six analysaient la durée du traitement et trouvaient des valeurs plus courtes dans le groupe expérimental que dans le groupe contrôle, avec un gain variant de 8 à 34 semaines. Cinq analysaient la vitesse du déplacement dentaire et trouvaient des valeurs 2,3 fois supérieures en moyenne au cours du premier mois dans les groupes expérimentaux et 1,9 fois au cours du deuxième et du troisième mois, enfin 1,3 fois au cours du quatrième mois. La technique semblait par ailleurs diminuer le risque de résorption radiculaire et améliorer l’ancrage molaire. De plus, elle présentait une bonne tolérance parodontale. Conclusion : La littérature actuelle met en exergue l’efficacité des décortications chirurgicales pendant les trois à quatre premiers mois post-opératoires. Des études prospectives plus longues devront être menées afin d’évaluer leurs effets sur le long terme.
Optimisation de l’occlusion statique linguale terminale : une analyse
Authors: Fourquet Lucile , Philippe Julien , Kerbrat Jean-Baptiste
Published: June 2017

Introduction : L’objectif de tout traitement orthodontique est d’aboutir à une occlusion fonctionnelle, esthétique et pérenne. Cependant, l’analyse se borne souvent à l’étude de sa partie vestibulaire, facilement observable en bouche. Or, l’occlusion linguale présente elle aussi une importance majeure. Matériel et méthode : Après avoir rappelé les objectifs statiques idéaux de fin de traitement, décrits dans la littérature et définis par certaines sociétés scientifiques, cet article étudie les différents supports d’analyse de l’occlusion statique linguale et propose un nouveau protocole de taille des moulages orthodontiques. Résultats : Les objectifs de fin de traitement du point de vue de l’occlusion linguale sont peu détaillés, que ce soit dans la littérature scientifique ou dans les critères des sociétés scientifiques, bien que nous disposions de moyens simples pour les étudier. Discussion : La partie linguale de l’occlusion reste rarement étudiée dans notre pratique quotidienne, notamment parce que son analyse ne peut se faire par une vision directe intrabuccale. Néanmoins, elle est d’une importance majeure dans la réussite et la stabilité de nos traitements.
Clinical Scoring Systems in Thrombotic Microangiopathies
Authors: Upadhyay Vivek , Sun Lova , Marques Marisa , Makar Robert , Bendapudi Pavan
Published: June 2017

Thrombotic microangiopathies (TMAs) are a group of rare but potentially lethal hematologic disorders characterized by platelet-rich thrombi in the microvasculature. In evaluating patients with TMA, it is crucial to identify those who have thrombotic thrombocytopenic purpura (TTP), a subtype of TMA that occurs due to a severe deficiency in ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 motif, member 13). Individuals with TTP require urgent therapeutic plasma exchange, which is associated with a significant reduction in mortality; however, at most centers, the results of ADAMTS13 activity testing are usually not available for 3 to 5 days. Given the possible need for urgent intervention and the lack of timely test results to guide therapy, the assessment of patients with TMA represents an ideal situation for the deployment of diagnostic scoring systems to predict the presence of severe ADAMTS13 deficiency. Here, we review the literature surrounding clinical prediction tools in the diagnosis and prognostication of patients with TMA, describe the experience at our center with evaluating TMA patients, and discuss the utility of clinical scoring systems for TMA in the context of patient care.