bluuebunny/crossref_metadata_2025 huggingface dataset:
Izotechnologies in the work of the teacher-speech therapist
Authors:   «Kindergarten №148», Yaroslavl, Nagle Kristina V.
Published: August 2021

The stage of automating the set sounds, especially in children with severe speech disorders, is a long and complex process. To make this process more interesting and entertaining for the child, we actively use visual technologies in our work. By making plasticine pictures, a speech therapist teacher can effectively interact with children who receive speech therapy assistance.
Clinical, psychological and pedagogical study of a child with special educational needs of preschool age in the framework of "team counseling»
Authors:   Kuzbass regional center for psychological, pedagogical, medical and social assistance, Anzhero-Sudzhensk, Shevkova Svetlana A.
Published: August 2021

The article is devoted to complex clinical and psycho-pedagogical study of children with disabilities of preschool age in the framework of "team consulting" in "Kuzbass regional center of psycho-pedagogical, medical and social care "Health and personal development."
Inclusive education: on the inclusion of a "special" child in a peer group
Authors:   Belarusian State Pedagogical University named after Maxim Tank, Khitryuk Vera V. , Kiseleva Tatyana G. ,   Yaroslavl state pedagogical university named after К. D. Ushinsky
Published: August 2021

The article describes the problem of including a "special" child in interaction with peers; identifies ways to resolve existing contradictions; outlines areas of work to modernize the content of teacher education in the context of the principle of inclusion.
Features of syntax and coherent speech in primary schoolchildren with developmental disabilities
Authors:   Khakass State University named after N.F. Katanov, Abakan, Fotekova Tatyana A.
Published: August 2021

The article presents the results of a comparative study of grammatical structuring and the construction of a coherent utterance in younger schoolchildren with general speech underdevelopment and mental retardation in comparison with the norm. A significant similarity in manifestations and the presence of specific features are shown. The predominance of the deficit of semantic programming in the case of mental retardation and the difficulties of semantic programming, serial organization and lexical formulation of the utterance in the general speech underdevelopment was revealed.
reeva Work on speech restoration in people with aphasia
Authors:   Volgograd State Social and Pedagogical University, Fureeva Elena P.
Published: August 2021

The article deals with the problem of speech restoration in persons with local lesions of the cerebral cortex, the peculiarities of interaction with patients and their relatives. The principles, tasks of restorative work in aphasia, the value of complex treatment are revealed.
Features of formation of understanding of prepositional-case constructions and their use by children of 2.5-3 years
Authors:   Leningrad State University named after A S. Pushkin, Yeletskaya Olga V. , Reshetko Marina A. ,   Children's center «Logos», Moscow
Published: August 2021

The development of prepositional-case constructions at the initial stage of the formation of expressive speech in early childhood is an important element of speech development. This article describes the organization and results of the examination of the state of understanding and production of prepositional-case constructions by children with delayed speech development and in the norm according to the modified method of speech therapy examination by V.D. Korolev and diagnostic materials by D.A. Shchukina. The features of understanding and producing prepositional-case constructions in locative and temporal meanings in children aged 2.5-3 years are considered.
Assistance to parents of children with disabilities in the process of counseling
Authors:   Institute of Correctional Pedagogy of the Russian Academy of Sciences, Moscow, Russia, Strebeleva Elena A. , Kinash Elena A. ,   Institute of Correctional Pedagogy of the Russian Academy of Sciences
Published: August 2021

The article is devoted to the problems of teaching children with special educational needs, the content presents the results of the analysis of the questions of parents who have applied to specialists (psychiatrist and teachers-defectologists) for psychological and pedagogical power. The most common questions that parents address for individual consultation of children with special educational needs and children with disabilities are systematized. The recommendations to parents on education and training of children with developmental disabilities are revealed.
The work of a speech therapist on the understanding of texts of different genres by preschoolers with speech disorders
Authors:   Irkutsk State University, Gostar Anna A. , Golzitskaya Olesya E. ,   Irkutsk State University
Published: August 2021

The article is devoted to the discussion of the activities of a speech therapist teacher to improve the understanding of texts of different genres by preschoolers with speech disorders. The article describes the understanding of fairy tales, poems and stories by children of older preschool age who have different levels of speech development with general speech underdevelopment. The directions of the speech therapist's work on understanding texts of different genres are highlighted and differentiated recommendations for speech therapist teachers are proposed.
Study of graphomotor skills in older preschoolers with dysarthria
Authors:   Yaroslavl state pedagogical university named after К. D. Ushinsky, Grosenkova Victoria A. , Ibragimova Sabina Z. ,   Yaroslavl state pedagogical university named after К. D. Ushinsky, Loginova Inna N. ,   Belarusian State Pedagogical University named after Maxim Tank
Published: August 2021

The article is devoted to the actual problem of studying graphomotor skills in preschool children with erased dysarthria. The authors of the article offer the results of a study of the formation of graphomotor skills in older preschoolers with normal speech development and general speech underdevelopment; they offer criteria for assessing the level of formation of this skill
On some results of training students-defectologists for health-preserving and health-forming activities
Authors:   Yaroslavl state pedagogical university named after К. D. Ushinsky, Tikhomirova Larisa F. , Skrigan Galina V. ,   Belarusian State Pedagogical University named after Maxim Tank
Published: August 2021

The function of preserving and strengthening the health of children occupies a special place in the activities of teachers of each educational institution. To carry out effective work on the preservation, strengthening and formation of children's health, it is necessary that the teachers themselves be ready to engage in health-preserving activities. The author notes that the most relevant and effective is the preparation of students at the university for the implementation of the function of preserving and strengthening the health of schoolchildren. The author reveals the conditions necessary to increase the level of readiness of students-defectologists for activities to preserve and strengthen the health of children.
About the professional competence of special education teachers
Authors:   Karaganda University named after E.A. Buketov, Ashimkhanova Gulbanu S. , Autaeva Akbota N. ,   Abai Kazakh National Pedagogical University
Published: August 2021

In this article, the authors consider the main conditions and ways to improve the quality of professional competence of teachers of special education. The main conditions for successful professional competence are the improvement of psychological and pedagogical and special knowledge about the competent interaction of a teacher and a child with special educational needs, the organization of the educational process aimed at developing the professional competence of teachers in teaching and raising children with special educational needs.
Family factors of psychosocial rehabilitation of children with hearing and visual impairments
Authors:   Tomsk State Pedagogical University, Karaush Irina S.
Published: August 2021

. The article presents the results of a survey of 368 students of 7-18 years of special (correctional) schools, including 186 students with hearing impairments (hard of hearing and deaf) and 182 visually impaired students and 280 parents of students of special schools. The characteristics of families are given, the main characteristics that affect the mental health of children, as well as the possibilities of rehabilitation intervention are identified
The originality of cognitive processes and the influence on forming of spelling competencies in schoolchildren with dysorphography
Authors:   School №10 of the Kalininsky district of St. Petersburg, Baigildina Vladlena V. , Yeletskaya Olga V. ,   Leningrad State University named after A S. Pushkin
Published: August 2021

The present study deals with an investigation of dysorthography at junior high school students who have a lack of form of non-speech processes. The characteristic features of the dysorthography source as a persistent and specific violation of the writing is highlightedand described.
Psychological and pedagogical support for families raising children with disabilities
Authors:   Priamursky State University Sholom Aleichem, Shklyar Natalia V. , Karynbaeva Olga V. ,   Priamursky State University Sholom Aleichem, Levkova Tatyana V. ,   Priamursky State University Sholom Aleichem
Published: August 2021

The article presents the main activities of the Advisory and Methodological Center for Assistance to families raising children aged 0 to 18 years, including children with disabilities, created within theframework of the federal project "Support for families with children" of the national project "Education". The experience of implementing a regional project on the territory of the Jewish Autonomous Region is summarized.
Validity of Urine Syndecan-1 as A Predictor of Acute Kidney Injury In Pediatric Sepsis Patients
Authors: Semedi Bambang Pujo , Utariani Arie , Budi Nugroho Setia , Asmaningsih Ninik , Andriyanto Lucky
Published: August 2021

Introduction: AKI (Acute Kidney Injury) complications in sepsis patients generally occur 24 hours after admission to ICU. Creatine Serum Concentration is a standard parameter to diagnose AKI. Unfortunately, the changes in creatine serum concentration will only be seen several days after the decrease of renal function to 50%.  The low detection ability has been linked with time loss before preventive therapy is commenced. Furthermore, this instigates the need for biomarkers to ensure early detection. Objective: This study aimed to identify cut-off points of urine syndecan-1 and to measure the prediction ability of urine syndecan-1 towards the AKI occurrence in pediatric sepsis patients. Materials and methods: This study was a prospective cohort study performed at a single center in Dr. Soetomo General Hospital, Surabaya. The inclusion criterion was all children admitted to the resuscitation room from October until December 2019. Furthermore, urine sampling is carried out at 0, 6, 12, and 24 hours for a syndecan-1 urine examination, and every procedure performed on the patient will be recorded. This action was continued up to the third day and aimed to evaluate some factors related to AKI at 48-72 hours of admission. Result and Discussion: Out of 41 pediatric sepsis patients, 30 patients fulfilled the inclusion criteria and 57% had AKI. The value of urine syndecan-1 at hour-0 and hour-6 was significantly featured a cut-off point. Conclusion: The value of urine syndecan-1 at hour-0 and hour-6 are valid parameters to predict the occurrence of AKI grades 1, 2, and 3 in pediatric septic patients at 48-72 hours after their hospital admission. The best cut-off value of urine syndecan-1 at the 0th hour was 0.67 ng/ml.
DISCREPANCY INR VALUE (INTERNATIONAL NORMALIZED RATIO) IN OPTICAL AND ELECTROMECHANICAL METHOD
Authors: Yunensie Putri Adelia
Published: August 2021

Background: INR examination services at laboratories in hospitals and clinics use different methods and tools therefore, results of the INR examination are different. Purpose: To determine whether there are differences in the INR value between using the photo optic method and electromechanical method. Method: This study used a citrate blood sample with a ratio of blood and anticoagulant 9: 1 and used the Sysmex CA-600 device for the photo optic method and used the Thrombostat device for the electromechanical method. The sample consisted of 32 samples, namely 10 treatment samples to be analyzed and 22 normal samples. Using SPSS 25.0 to test data that was tested for normality test and in a different test. Result: The result of INR with the electromechanical method was significantly longer than INR with the photo optic method. In the hemolytic sample, the result was significantly higher than the INR result with normal samples. Conclusion: There are significant differences between results of the INR value using photo optic and electromechanical due to the difference in the detection principle between the two methods.
MODES OF SARS-COV-2 TRANSMISSION
Authors: Patel Nilesh D. , Desai Kairavi J. , Patel Shirishkumar M.
Published: August 2021

Background: On 12th December 2019, pneumonia of unknown etiology was reported in number of human cases from Wuhan, central China. On 11th February 2020, the WHO named the disease COVID-19, short for “COronaVIrus Disease 2019”. This COVID-19 out-break has grown substantially to that of pandemic nature currently. Close personal contact and respiratory droplets from sneezes and coughs of patient can disseminate SARS-CoV-2. The WHO continues to stress the usefulness of environmental cleaning and disinfection, frequent hand hygiene, respiratory etiquette. The WHO also suggests avoidance of close, unprotected contact and maintenance of physical distance with people having fever or respiratory symptoms. Purpose: To develop strategies for lowering transmission of COVID-19, development of ways for distinguishing the various modes of transmission such as urine and fecal samples is need of the hour. Review: In a clinical scenario where possibility of vertical transmission of Covid-19 is increasingly being reported and transplacental transmission of the SARS-COV-2 cannot be ruled out, medical fraternity requires more evidence on vertical transmission for better mother and newborn care. Conclusion: In order to study the vertical dissemination of SARS-CoV-2, the heath authorities should include additional examinations of maternal and newborn samples in standard treatment guideline for pregnant women.
Analysis of Sub-Sector Performance of Agriculture in Pekalongan Regency, 2013-2017
Authors: Wati Rahayu Mustika , Setiarso Oke , Arifin Agus
Published: August 2021

This research is secondary data research in the agricultural sub-sectors, those are food crops, horticulture, plantations, animal husbandry, agriculture and hunting services, forestry and logging, and fisheries in Pekalongan Regency in 2013-2017. The purpose of this research is to analyze the classification of growth and the contribution of plantations sub-sector production. This research used analysis tools, they were Klassen Typology and Contribution Production of superior products in each district. The results of this research show growth classification consist of four quadrants: quadrant I that doesn’t have advanced agricultural sub-sectors. Quadrant II contained horticultural crops, forestry and logging, and fisheries, while in Quadrant III there were plantation crops, and in Quadrant IV there were food crops, livestock, and agricultural and hunting services. Pekalongan Regency has 19 districts, with 15 products of plantation crop. Contribution Production shows that Paninggaran District had the highest contribution of plantation crops in the Pekalongan Regency.Keywords: Agriculture Sub Sector, Growth Classification, Contribution
Determinants of Big and Medium Industrial Manufacturing Agglomeration in West Java Province
Authors: Karima Nur Annisa , Badriah Lilis Siti , Gunawan Diah Setyorini
Published: August 2021

The aims of this research are to analyze whether or not the manufacture industrial agglomeration in West Java Province and to analyze the factors that can affect the agglomeration especially manufacture industrial agglomeration in West Java Province. This research using Hoover Balassa Index and panel data regression with time period data 6 years (2014-2019) and 27 regencies/cities as cross-section data. The results of this research are : (1) there is no manufacture industrial agglomeration in West Java Province, (2) gross regional domestic product has a negative effect on manufacture industrial agglomeration, (3) minimum wage has a positive effect on manufacture industrial agglomeration, (4) population has a negative effect on manufacture industrial agglomeration. As an implication of the conclusion above, every province or regency/city should seek and make their region as a pole of the agglomeration and the effort that can be done are create some regulations which can support industrial establishment and development easier, giving the information about business and capital, create some regulations about wage, building partnership among companies to create backward and forward linkage.Keywords: Agglomeration, Hoover Balassa Index, Concentration Index
Antioxidant Activity and Total Phenol Extract of Kecombrang Flower, Stem and Leaves with Different Types of Solutions
Authors: Nuryanti Siti , Latifasari Nurul , Naufalin Rifda , Wicaksono Rumpoko , Erminawati Erminawati
Published: August 2021

Kecombrang (Etlingera elatior) is one of the spices which is quite widespread in Indonesia and has many uses. Kecombrang extract has the potential as an antioxidant and natural antimicrobial to extend the shelf life of food products. Extraction was carried out by multilevel maceration method with different types of solvents. This study aims to determine the effect of extraction on the bioactive components of flowers, stems and leaves of kecombrang in different types of solvents and determine the antioxidant activity and total phenols of each type of kecombrang plant extract.The results showed that extraction with distilled water produced the highest total phenol, antioxidant activity and yield on kecombrang leaves. The total phenol extracts of n-hexane leaves, leaves of ethyl acetate, and leaves of kecombrang distilled water were 19.116, 10.276, and 45.008 (mg TAE g db -1) respectively. The antioxidant activity value of flowers, stems and leaves of distilled water solvent kecombrang are 69.754, 72.648, and 78.003 (%) respectively. The yield for flowers, stems and leaves with distilled water solvent is 15.9; 16.6 and 32.95 (%) respectively.
The HMG-CoA Reductase Inhibitor Activities of Soy Protein Hydrolysates from Papain Hydrolysis
Authors: Hermanto Sandra , Octavio Aldi , Azrifitria Azrifitria , Kusumaningrum Susi
Published: August 2021

The search for an HMG-CoA reductase inhibitor agent as a safe and inexpensive alternative treatment for hypercholesterolemia has been carried out using soy protein hydrolysates as one of the bioactive peptide sources. This study was conducted to explore the potency of soy protein hydrolysates as an anti hypercholesterolemia agent by an in vitro assay, through the inhibition capacity of the HMG-CoA (3-hydroxy-3-methyl glutaryl-coenzyme A) reductase enzyme as a key component of cholesterol biosynthesis. Sample preparation started with soy protein isolation through acid precipitation and separated by centrifugation. The samples were analyzed the proximate content and hydrolyzed by papain enzyme at concentration 0.2% (w/v), for 0-6 hours and at 37, 50, and 55 oC. The protein hydrolysates were subsequently evaluated for hydrolysis degree (% DH), hydrolysates profile with SDS-PAGE (Sodium Dodecyl Sulphate Polyacrylamide Gel Electrophoresis), and anti-cholesterol assay through HMG-CoA reductase inhibition tests. The sample with the highest inhibition activity was fractionated using gel filtration chromatography (Sephadex G-10) and the molecular weight of fractions was characterized by LCMS QTOF (Liquid Chromatography-Mass Spectrometry Quadrupole Time-of-Flight) for molecular weight determination. The results indicated the optimum hydrolysis conditions of soy protein isolates were obtained at 3 hours incubation, at 50 °C with DH 33.39% and the inhibition value was 95.65% (protein concentration 39.21 μg / mL). LCMS data showed the molecular weight of fractionated peptides were 1514 and 2029 Da. We assumed that both peptides have the same affinity as previous peptides in inhibiting HMG-CoA reductase.
Chemical Sensor for Detection of Lead Levels in Herbal Medicine
Authors: Mulyasuryani Ani , Prananto Yanuar Ponco , Krisnaniningrum Elvian Eka
Published: August 2021

A new tube type Pb2+ sensor made from two types of mixtures, namely clay-PbI2 and chitosan-PbI2 were prepared. An electromotive force (EMF) with Ag/AgCl as the reference electrode was used as the output signal. The highest performance of the Pb2+ sensor from clay-PbI2 was obtained at Pb2+ solutions in HNO3 and pH 3 with sensor sensitivity of 20.67 mV/decade. The highest performance of the Pb2+ sensor from chitosan-PbI2 was obtained at Pb2+ solutions in demineralized water with sensor sensitivity of 32.49 mV / decade. Application of the two sensors on several commercial herbal samples resulted in an average recovery of 85.62% and 94.10% for sensor from chitosan-PbI2 and clay-PbI2, respectively
Backmatter (Instruction for author and back cover)
Authors: Fatoni Amin
Published: August 2021

Backmatter (Instruction for author and back cover)
Requirements Engineering of Village Innovation Application Using Goal-Oriented Requirements Engineering (GORE)
Authors: Kartiko Condro , Wardhana Ariq Cahya , Saputra Wahyu Andi
Published: August 2021

The delay in the absorption of village funds from the central government to the village government is due to the village government's difficulty preparing village development innovation programs. The innovation tradition will grow if the cycle of transformation of knowledge and acceptable practices from one village to another, especially villages with similar conditions and problems, can run smoothly.  For the process of exchanging knowledge and experiences between villages to run smoothly, it is necessary to codify best practices in a structured, documented, and disseminated manner. This research aims to design an application that functions as a medium for sharing knowledge about the use of village funds through government innovation narratives. The application is expected to become a reference for villages to carry out innovative practices by conducting replication studies and replicating acceptable practices that other villages have done. Therefore, it is necessary to have a system requirements elicitation method that can explore the village's requirements in sharing knowledge so that the resulting system is of high quality and by the objectives of being developed. There are several Goal-Oriented Requirements Engineering (GORE) methods used, such as Knowledge Acquisition in Automated Specification (KAOS) and requirements engineering based on business processes. In this research, the KAOS method was demonstrated as the elicitation activity of a village innovation system. Then the results were stated in the Goal Tree Model (GTM). Model building begins with discussions with the manager of the village innovation program to produce goals. The goals are then broken down into several sub-goals using the KAOS method. The KAOS method is used for the requirements elicitation process resulting in functional and non-functional requirements. This research is the elicitation of the requirement for the village innovation system so that it can demonstrate the initial steps in determining the requirements of the village innovation system before carrying out the design process and the system creation process. The results of this requirement elicitation can be used further in the software engineering process to produce quality and appropriate village innovation applications.
Petri Net-Based Semi-Compiled Code Generation for Programmable Logic Controllers
Authors: Azkarate Igor , Ayani Mikel , Mugarza Juan Carlos , Eciolaza Luka
Published: August 2021

Industrial discrete event dynamic systems (DEDSs) are commonly modelled by means of Petri nets (PNs). PNs have the capability to model behaviours such as concurrency, synchronization, and resource sharing, compared to a GRAphe Fonctionnel de Commande Etape Transition (GRAFCET) which is a particular case of a PN. However, there is not a systematic way to implement a PN in a programmable logic controller (PLC), and so it is very common the implementation of such a controller outside a PLC, in some external software that will communicate with the PLC. There have been some attempts to implement PNs within a PLC, but they are dependent on how the logic of places and transitions is programmed for each application. This work proposes a novel application-independent and platform-independent PN implementation methodology. This methodology is a systematic way to implement a PN controller within industrial PLCs. A great portion of the code will be validated automatically prior to PLC implementation. Net structure and marking evolution will be checked on the basis of PN model structural analysis, and only net interpretation will be manually coded and error-prone. Thus, this methodology represents a systematic and semi-compiled PN implementation method. A use case supported by a digital twin (DT) is shown where the automated solution required by a manufacturing system is carried out and executed in two different devices for portability testing, and the scan cycle periods are compared for both approaches.
Heterogeneous Double Metal Cyanide Catalyzed Synthesis of Poly(ε-caprolactone) Polyols for the Preparation of Thermoplastic Elastomers
Authors: Tran Chinh Hoang , Lee Min Woong , Park Sang Woo , Jeong Jae Eon , Lee Soo Jeong , Song Wenliang , Huh PilHo , Kim Il
Published: August 2021

A series of polycaprolactones (PCLs) with molecular weights of 950–10,100 g mol−1 and Ð of 1.10–1.87 have been synthesized via one-pot, solvent-free ring-opening polymerization (ROP) of ε-caprolactone (CL) using a heterogeneous double metal cyanide (DMC) catalyst. Various initiators such as polypropylene glycol, ethylene glycol, propylene glycol, glycerol, and sorbitol are employed to tune the number of hydroxyl end groups and properties of the resultant PCLs. Kinetic studies indicate that the DMC-catalyzed ROP of CL proceeds via a coordination mechanism. Branched PCLs copolymers are also synthesized via the DMC-catalyzed copolymerization of CL with glycidol. The α,ω-hydroxyl functionalized PCLs were successfully used as telechelic polymers to produce thermoplastic poly(ester-ester) and poly(ester-urethane) elastomers with well-balanced stress and strain properties.
Stochastic Planning and Operational Constraint Assessment of System-Customer Power Supply Risks in Electricity Distribution Networks
Authors: Kisuule Mikka , Hernando-Gil Ignacio , Serugunda Jonathan , Namaganda-Kiyimba Jane , Ndawula Mike Brian
Published: August 2021

Electricity distribution network operators face several operational constraints in the provision of safe and reliable power given that investments for network area reinforcement must be commensurate with improvements in network reliability. This paper provides an integrated approach for assessing the impact of different operational constraints on distribution network reliability by incorporating component lifetime models, time-varying component failure rates as well as the monetary cost of customer interruptions in an all-inclusive probabilistic methodology that applies a time-sequential Monte Carlo simulation. A test distribution network based on the Roy Billinton test system is modelled to investigate the system performance when overloading limits are exceeded as well as when preventive maintenance is performed. Standard reliability indices measuring the frequency and duration of interruptions, and the energy not supplied are complemented with a novel monetary reliability index. The comprehensive assessment includes not only average indices but also their probability distributions to adequately describe the risk of customer interruptions. Results demonstrate the effectiveness of this holistic approach as the impacts of operational decisions are assessed from both reliability and monetary perspectives. This informs network planning decisions through optimum investments and consideration of customer outage costs.
ZFTool: A Software for Automatic Quantification of Cancer Cell Mass Evolution in Zebrafish
Authors: Carreira María J. , Vila-Blanco Nicolás , Cabezas-Sainz Pablo , Sanchez Laura
Published: August 2021

Background: Zebrafish (Danio rerio) is a model organism emerged for the study of human cancer. Compared with the murine model, the zebrafish model has several properties ideal for personalized therapies. The transparency of the zebrafish embryos and the development of the pigment-deficient “casper” zebrafish line give the capacity to directly observe cancer formation and progression in the living animal. Automatic quantification of cellular proliferation in vivo is critical to the development of personalized medicine. Methods: A new methodology was defined to automatically quantify the cancer cellular evolution. ZFTool was developed to establish a base threshold that eliminates the embryo auto-fluorescence and automatically measures the area and intensity of GFP (green-fluorescent protein) marked cells and define a proliferation index. Results: Proliferation index automatically computed on different targets demonstrates the efficiency of ZFTool to provide a good automatic quantification of cancer cell evolution and dissemination. Conclusion: Our results demonstrate that ZFTool is a reliable tool for the automatic quantification of the proliferation index, being a measure of cancer mass evolution in zebrafish eliminating the influence of its autofluorescence.
PrimeNet: Adaptive Multi-Layer Deep Neural Structure for Enhanced Feature Selection in Early Convolution Stage
Authors: Khan Farhat Ullah , Abdul Aziz Izzatdin , Akhir Emelia Akashah Patah
Published: August 2021

The colossal depths of the deep neural network sometimes suffer from ineffective backpropagation of the gradients through all its depths. Whereas, The strong performance of shallower multilayer neural structures prove their ability to increase the gradient signals in the early stages of training which easily gets backpropagated for global loss corrections. Shallow neural structures are always a good starting point for encouraging the sturdy feature characteristics of the input. In this research, a shallow, deep neural structure called PrimeNet is proposed. PrimeNet is aimed to dynamically identify and encourage the quality visual indicators from the input to be used by the subsequent deep network layers and increase the gradient signals in the lower stages of the training pipeline. In addition to this, the layerwise training is performed with the help of locally generated errors which means the gradient is not backpropagated to previous layers, and the hidden layer weights are updated during the forward pass, making this structure a backpropagation free variant. PrimeNet has obtained state-of-the-art results on various image datasets, attaining the dual objective of (1) compact dynamic deep neural structure, which (2) eliminates the problem of backwards-locking. The PrimeNet unit is proposed as an alternative to traditional convolution and dense blocks for faster and memory-efficient training, outperforming previously reported results aimed at adaptive methods for parallel and multilayer deep neural systems.
Oleuropein-Rich Leaf Extract as a Broad Inhibitor of Tumour and Macrophage iNOS in Apc Mutant Rat Model
Authors: Ruzzolini Jessica , Chiccoli Sofia , Monaco Noemi , Peppicelli Silvia , Andreucci Elena , Urciuoli Silvia , Romani Annalisa , Luceri Cristina , Tortora Katia , Calorini Lido , Caderni Giovanna , Nediani Chiara , Bianchini Francesca
Published: August 2021

Abstract: Oleuropein, the major compound of olive leaves, has been reported to exert numerous pharmacological properties, including anti-inflammatory, antidiabetic and anticancer. The purpose of this study is to evaluate, for the first time, the effect of oleuropein-rich leaf extracts (ORLE) in already-developed colon tumours colon tumours arising in an Apc (adenomatous polyposis coli) mutated PIRC rats (F344/NTac-Apcam1137). Here, we were able to investigate in parallel the anti-cancer effect of ORLE, both in vivo and in vitro, and its anti-inflammatory effect on macrophages, which represents a critical and abundant population in most solid tumours microenvironment. We found that in vivo ORLE treatment promoted apoptosis and attenuated iNOS activity both in colon tumours as in peritoneal macrophages of PIRC rats. We confirmed in vitro using primary RAW264.7 cells: ORLE reduced iNOS activity in parallel with COX-2 and pro-inflammatory cytokines, such as IL-1, IL-6 and TGF-. These findings suggest that ORLE possess a strong anti-inflammatory activity, which could be crucial for dampening the pro-tumourigenic activity elicited by a chronic inflammatory state generated by either tumour cells or tumour-associated macrophages.
Relationship Among Welding Defects with Convection and Material Flow Dynamic Considering Principal Forces in Plasma Arc Welding
Authors: Nguyen Loc , Nguyen Van Anh , Duy Han Le , Nguyen Thanh-Hai , Tashiro Shinichi , Tanaka Manabu
Published: August 2021

The material flow dynamic and velocity distribution on the melted domain surface play a crucial role on the joint quality and formation of welding defects. In this study, authors investigated the effects of the low and high currents of plasma arc welding on the material flow and thermodynamics of molten pool and its relationship to the welding defects. The high-speed video camera (HSVC) was used to observe the convection of the melted domain and welded-joint appearance. Furthermore, to consider the Marangoni force activation, the temperature on the melted domain was measured by a thermal HSVC. The results revealed that the velocity distribution on the weld surface was higher than that inside the molten weld pool due to the difference of the massive density between the air and the steel. Moreover, in the case of low welding current (80A) the convection speed of molten was faster than that of the high welding current case (160A) owing to the difference of main driving forces direction and strength, which leading to undercut and humping defects on the weld surface and excessive convex (burn-through) defect at the bottom weld side, respectively. The medium welding current (120A) had two convection patterns with the main flow in backward direction, which resulted in better welding quality without defect. The interaction between the shear force and Marangoni force played a solid state on the convection and heat transportation processes in the plasma arc welding process.
The Biology of Colicin M and Its Orthologs
Authors: Chérier Dimitri , Patin Delphine , Blanot Didier , Touzé Thierry , Barreteau Hélène
Published: August 2021

The misuse of antibiotics during the last decades led to the emergence of multidrug resistant pathogenic bacteria. This phenomenon constitutes a major public health issue. Consequently, the discovery of new antibacterials in the short term is crucial. Colicins, due to their antibacterial properties, thus constitute good candidates. These toxin proteins, produced by E. coli to kill enteric relative competitors, exhibit cytotoxicity through ionophoric activity or essential macromolecule degradation. Among the 25-colicin types known to date, colicin M (ColM) is the only one colicin interfering with peptidoglycan biosynthesis. Accordingly, ColM develops its lethal activity in E. coli periplasm by hydrolyzing the last peptidoglycan precursor, lipid II, into two dead-end products, thereby leading to cell lysis. Since the discovery of its unusual mode of action, several ColM orthologs have also been identified based on sequence alignments; all of the characterized ColM-like proteins display the same enzymatic activity of lipid II degradation and narrow antibacterial spectra. This publication aims at being an exhaustive review about what is currently known on this new family of antibacterial enzymes as well as on their potential use of food preservatives or therapeutic agents.
Designing in the Cultural Rural Landscape. A Teaching Opportunity to Experiment a Research-by-Design Process Applied to an Italian UNESCO Wine Site
Authors: Dezio Catherine , Zhang Can , Zhang Yilan , Marino Davide
Published: August 2021

Rural landscapes all over the world are subject to great transformations, first of all the continuous and slow depopulation of land and villages. It is a dramatic phenomenon that causes devastating consequences for environmental systems and for the tangible and intangible heritage of entire territories. The situation becomes more ambiguous when it comes to cultural landscapes, especially those internationally recognized as exceptional (i.e. inscribed on the UNESCO World Heritage List). In this case, the risk is to abandon agricultural production in favor of consumerist tourist economies, which can damage the territorial authenticity. In this paper we question the role of the landscape project in strengthening territorial resilience. In particular, a composite and interdependent action is proposed between landscape design and implementation of a multifunctional agriculture model, oriented towards teaching and tourism. To undertake this investigation, a master's thesis work on Landscape Architecture is examined, as an opportunity for a research-by-design method. The application case is the Italian UNESCO site of Vignale Monferrato, a depopulated rural village, characterized by abandoned land and buildings. The paper concludes by outlining replicability application scenarios for the proposed model.
Mathematical Modelling from the Instrumentation of Improper Integrals
Authors: Mateus-Nieves Enrique , Wilfaver Hernández Montañez
Published: August 2021

Background: There is little clarity in the application of content related to improper integrals in university students, due to the absence of meaning, which prevents them from making a connection with everyday problem situations. Methods: we designed a mathematical modelling proposal where a specific situation involving the instrumentation, use and application of this type of integrals is experimented and solved with a population of engineering students, who learn to use them. Results: The importance of using mathematical modelling as a didactic-dynamic resource is highlighted because it helps students to reach an understanding of real situations involving improper integrals in different contexts. Conclusions: Despite the numerous errors detected in the students, this strategy made it possible to demonstrate the development of advanced mathematical thinking skills in young people.
Characterization of Conserved and Promiscuous Human Rhinovirus CD4 T Cell Epitopes
Authors: Gomez-Perosanz Marta , Fiyouzi Tara , Fernandez-Arquero Miguel , Sidney John , Sette Alessandro , Reinherz Ellis L. , Lafuente Esther M. , Reche Pedro A.
Published: August 2021

Human Rhinovirus (HRV) is the most common cause of upper respiratory infections and exacerbations of asthma. In this work, we selected 14 peptides (6 from HRV A and 8 from HRV C) encompassing potential CD4 T cell epitopes. Peptides were selected for being highly conserved in HRV A and C serotypes and predicted to bind to multiple HLA II molecules. We found positive T cell recall responses by IFNγ-ELISPOT assays to 8 peptides, validating 7 of them (3 from HRV A and 4 from HRV C) as CD4 T cell epitopes through intracellular cytokine staining assays. Additionally, we verified their promiscuous binding to multiple HLA II molecules by quantitative binding assays. According to their experimental HLA II binding profile, the combination of all these 7 epitopes could be presented and recognized by > 95 % of the world population. We actually determined IFNγ responses to a pool encompassing these CD4 T cell epitopes by intracellular cytokine staining, finding positive responses in 29 out of 30 donors. The CD4 T cell epitopes identified in this study could be key to monitor HRV infections and to develop peptide-based vaccines against most HRV A and C serotypes.
Single Cell Center of Mass for the Analysis of BMP Receptor Heterodimers Distributions
Authors: Boog Hendrik , Medda Rebecca , Cavalcanti-Adam Elisabetta Ada
Published: August 2021

At the plasma membrane, transmembrane receptors are at the interface between cells and their environment. They allow sensing and transduction of chemical and mechanical extracellular signals. The spatial distribution of receptors and the specific recruitment of receptor subunits to the cell membrane is crucial for the regulation of signaling and cell behavior. However, it is challenging to define what regulates such spatial patterns for receptor localization, as cell shapes are extremely diverse when cells are maintained in standard culture conditions. Bone morphogenic protein receptors (BMPRs) are serine-threonine kinases, which build heteromeric complexes of BMPRI and II. These are especially interesting targets for receptor distribution studies, since the signaling pathways triggered by BMPR-complexes depends on their dimerization mode. They might exist as pre-formed complexes, or assemble upon binding of BMP, triggering cell signaling which leads to differentiation or migration. In this work we analyzed BMPR receptor distributions in single cells grown on micropatterns, which allows not only to control cell shape, but also the distribution of intracellular organelles and protein assemblies. We developed a script called ComRed (Center Of Mass Receptor Distribution), which uses center of mass calculations to analyze the shift and spread of receptor distributions according to the different cell shapes. ComRed was tested by simulating changes in experimental data, showing that shift and spread of distributions can be reliably detected. Our ComRed-based analysis of BMPR-complexes indicates that receptor distribution depends on cell polarization. The absence of a coordinated internalization after addition of BMP suggests that a rapid and continual recycling of BMPRs occurs. Receptor complexes formation and localization in cells induced by BMP might yield insights into the local regulation of different signaling pathways.
Using Cloud-Based Array Electromagnetics on the Path to Zero Carbon Footprint during the Energy Transition
Authors: Strack Kurt , Davydycheva Sofia , Passalacqua Herminio , Smirnov Maxim Y. , Xu Xiayu
Published: August 2021

One of the key geophysical technologies for the energy industry during energy transition to zero footprint is fluid imaging. Knowledge of fluid distribution allows better, more optimized production reducing thus CO2 footprint per barrel produced and for CO2 storage the knowledge of where stored fluids go is mandatory to monitor reservoir seals. Electromagnetic is the preferred way to image fluid due to its strong coupling to the fluid resistivity. Unfortunately, acquiring and interpreting the data takes too long to contribute significantly to field operation and cost optimization. Using artificial intelligence and Cloud based data acquisition we can reduce the operational feedback to near real time and for the interpretation to close to 24 h. This then opens new door for the usefulness of this technology from exploration, monitoring and allows the application envelope to be enlarged to much noisier environment where real time acquisition can be optimized based on the acquired data.
Islam and State: A Study on Al-Mawardi and An-Nabhani’s thought and its Compatibility in Indonesian Context
Authors: Rohman Fathor , Basya M Hilali , Sopa Sopa
Published: August 2021

Even though study concerning Islam and politics has been conducted by many researchers, few of them investigating about compatibility of Islamic political thoughts, which originated from the classical and medieval periods that have been influencing Islamic political movements and thoughts in Indonesia, with Indonesian context. Thoughts of Imam al-Mawardi (lived in the 12th Century) and Taqiyuddin al-Nabhani (lived in the 20th Century) are some of them that should be mentioned in this regard. Islamic political thoughts of al-Mawardi become the main reference for Sunni Muslims who are majority in Indonesia, while Islamic political thought of al-Nabhani become the main guidance of HTI (Hizbut Tahrir Indonesia) movement of which its members and followers are many in Indonesia. This article investigates about the political thoughts of al-Mawardi and al-Nabhani concerning the relationship between Islam and state as well as their compatibility with Indonesian context. This study uses the library research in which its primary resources are books written by al-Mawardi entitled Al-Ahkam al-Sulthaniyah and al-Nabhani entitled Ad-Daulah al-Islamiyah. By utilizing qualitative content analysis, data were collected and analyzed. This article argues that the Islamic political thought of al-Mawardi has been adopted by majority of Indonesian Sunni Muslims with some adjustments with Indonesian context, so that his thoughts become compatible with the concept of modern nation-state of Indonesia.  On the other side, Islamic political thought of al-Nabhani which developed within a spirit of resistance to Western (European) colonialism has been adopted and campaigned by HTI without adjustment with Indonesian context. This causes al-Nabhani’s thought clashes with the concept of modern nation-state of Indonesia.
The Tafsīr Bi Al-Ma’ṡūr and Bi Al-Ra’yī in The Commentary of Abū Ja’far Al- Ṭaḥāwī
Authors: Hasan Moh. Abdul Kholiq
Published: August 2021

This study aims to investigate the tafsīr bi al-ma’ṡūr and bi al-ra’yī in the commentary of Abū Ja’far al-Ṭaḥāwī and its application methods. This study employed analytical descriptive method by employing content analysis theory towards the commentary of Aḥkām Al-Qur’ān Al-Karīm. The results suggest that Al-Ṭaḥāwī incorporates the tafsīr bi al-ma’ṡūr and bi al-ra’yī in his commentary although the general style is still the tafsīr bi al-ma’ṡūr. Al- Ṭaḥāwī has his own method in implementing the tafsīr bi al-ma’ṡūr and bi al-ra’yī. Among his methods in tafsīr bi al-ma’ṡūr is to compromise amongst narrations if it is possible, select and scientifically criticize the narrations, no comment, and avoid rejected Isrāiliyyāt narrations and false hadiṡ, unlike the commentary of al-Ṭabari. It is possible due to the differences of character between these two commentaries. Meanwhile, his method in tafsīr bi al-ra’yī is to reconcile both reasons and narrations in balance and equally important, avoid reasons outside their domain, interpret mutasyābihāt with muḥkamāt, and avoid wrong interpretation. Therefore, al-Ṭaḥāwī’s commentaries have been based on correct principles.