bluuebunny/crossref_metadata_2025 huggingface dataset:
Mathematical Model of Foot and Mouth Disease Considering Vaccination Disinfection And Early Quarantine
Authors: Nur Wahyudin , Darmawati Darmawati , Afni Nur , Bulawan Sriwana , Haeni Nur , Abdullah Abdullah , Nirma Nirma , Aspar Muhammad , Salim Salim
Published: June 2023

Foot and Mouth Disease (FMD) is a highly contagious disease that can infect all cloven hoofed animals. FMD is one of the most important infectious viral diseases in the world. This disease is responsible for international losses in livestock production and trade. In this article, we formulate a mathematical model for the spread of FMD in goat farms that considers early quarantine, vaccination, and disinfection interventions. The model constructed is expressed as a system of ordinary differential equations consisting of eight state variables. We determine the basic reproduction number using the next-generation matrix method. Our numerical simulation results show that vaccination has a very crucial role in controlling the spread of FMD and reducing the basic reproduction number. In addition, quarantine interventions for latent and infectious goats are also effective in controlling the spread of FMD. The basic reproduction number can also be suppressed by disinfection and quarantine interventions. Therefore, we recommend implementing routine vaccination, screening and disinfection programs. In addition, farmer should be given education so that they have the ability to identify goats exposed to FMDV so that quarantine can be carried out early.
Impairement of Left Ventricular Global Longitudinal Strain in Hypertensive Patients, A Serial of 333 Moroccan Patients
Authors: Ouarrak Safia
Published: June 2023

Heart failure with preserved ejection fraction (HFpEF) is a major public health problem. It indicates a primary problem in the ability of the ventricles to relax and fill normally. HFpEF is associated with high morbidity and mortality particularly in hypertensive patients. It is responsible for approximately half of all heart failure hospitalizations, with mean survival similar to those with heart failure with reduced ejection fraction. A strong correlation exists between impaired diastolic function and longitudinal systolic dysfunction. It is due to left ventricle (LV) remodeling and hypertrophy. The Early detection of subclinical LV systolic dysfunction in hypertensive patients is important for the prevention of progression of the disease, and to avoid symptomatic heart failure.
Survei Tingkat Kebugaran Jasmani Siswa Kelas X SMA Negeri 4 Bantaeng
Authors: Rahmiati Nur , Janwar Muhammad , Cakrawijaya Muhammad Hidayat
Published: June 2023

Penelitian ini bertujuan untuk mengetahui tingkat kebugaran jasmani siswa kelas X SMA Negeri 4 Bantaeng. Variabel dalam penelitian ini adalah tingkat kebugaran jasmani, dengan populasi sebanyak 277 siswa dan jumlah sampel dalam penelitian ini sebanyak 55 siswa yaitu 28 siswa laki-laki dan 27 siswa perempuan. Dengan teknik pengambilan sampel menggunakan teknik Random Sampling. Penelitian ini menggunakan instrumen Tes Kebugaran Jasmani Indonesia (TKJI) untuk usia 16-19 tahun yaitu: tes lari 60 meter, tes gantung angkat tubuh/gantung siku tekuk 60 detik, tes baring duduk 60 detik, tes loncat tegak, dan tes lari 1200/1000 meter. Teknik analisis data yang digunakan adalah statistik deskriptif dengan menggunakan  analisis statistik dengan bantuan SPSS (Statistical Package for Sosial Science) versi 24. Hasil penelitian menunjukkan bahwa tingkat kebugaran jasmani siswa kelas X SMA Negeri 4 Bantaeng dengan klasifikasi baik sekali sebanyak 0 siswa dengan persentase 0%, klasifikasi  baik sebanyak 3 siswa dengan persentase 5.5%, klasifikasi sedang sebanyak 26 siswa dengan persentase 47,3%, klasifikasi kurang sebanyak 23 dengan persentase 41.8%, klasifikasi kurang sekali sebanyak 3 siswa dengan persentase 5.5%. Sebagian besar tingkat kebugaran jasmani siswa kelas X SMA Negeri 4 Bantaeng termasuk dalam klasifikasi sedang.
أثر نظم المعلومات الإستراتيجية في تحقيق الميزه التنافسيه
Authors: عبد الغنى أحمد عثمان  , د. وليد  أحمد خلف  الله
Published: June 2023

هدفت هذه الدراسة الى معرفة أثر نظم المعلومات الإستراتيجية في تحقيق الميزة التنافسية لمنظمات الأعمال العاملة بولاية الخرطوم. إستخدمت الدراسة المنهج الوصفي التحليلي لاختبار العينات الغير احتمالية باستخدام اسلوب العينات القصدية. استخدمت الأستبانه كاداءة رئيسية لجمع البيانات وتحليلها، حيث تم توزيع عدد(50) استبانة ومن ثم جمعها وتحليلها وإجراء إختبارات الصدق والثبات عليها اضافة الى الاحصاء الوصفي . ولاختبار فرضيات الدراسة تم استخدام طريقة الإنحدار عن طريق برنامج التحليل الأحصائي للاغراض الأجتماعية (SPSS). وتوصلت الدراسه الى وجود أثر لنظم المعلومات الإستراتيجية بابعادها المتطلبات التنظيمية والمتطلبات التكنولجية في تحقيق الميزة التنافسية. واوصت الدراسة المنظمات بالأهتمام بنظم المعلومات الإستراتيجية لتحقيق الميزه التنافسية واشراك العاملين في مختلف مراحل صياغة الخطة الاستراتجية.
الخطاب التعليمي في أندلس الخلافة الأموية
Authors: الدكتور ابن عمر عمر عبيدالله  , د. علي اجمد علي جادالله
Published: June 2023

هذه الورقة تتناول الخطاب التعليمي في أندلس الخلافة الأموية ( 316-399هـ )(929-1008م) ويأتي تناول الورقة للخطاب متسقا مع التطورات والمتغيرات التاريخية التي شهدتها تلك الفترة ، وتركز تحديدا على مرحلة الخلافة الأموية، وتهدف عبر محاورها المختلفة إلى التعرف على الخطاب التعليمي في أندلس تلك الفترة ، كما تهدف الورقة إلى توضيح أهم ملامح الخطاب التعليمي في الأندلس والحضور المذهبي والفقهي وسمات الحركة العلمية ودور مؤسسات ونظام التعليم ومشاركة النساء في التعليم في تلك الفترة
أثر التسويق الريادي على الأداء المستدام، دراسة على عينة من الشركات الصناعية العاملة في ولاية الخرطوم (2023م)
Authors: أ. عماد محمد محمد الحسن دفع الله  , أ.د. علي عبدالله محمد الحاكم
Published: June 2023

هدفت الدراسة إلى معرفة أثر التسويق الريادي على الأداء المستدام في الشركات الصناعية العاملة بولاية الخرطوم، وقد استخدمت الدراسة المنهج الوصفي التحليلي، إستناداً إلى نظرية أصحاب المصلحة  ومراجعة الأدبيات، تم بناء نموذج الدراسة وفرضياتها إعتماداً على أدبيات الدراسة وكذلك تم الإستعانة بالدراسات السابقة في تطوير مقاييس الدراسة، وصممت إستبانه لجمع البيانات من عينة غير إحتمالية (ميسرة)، حيث تم توزيع عدد (354) إستبانه واسترد منها (290) بنسبة إستجابة بلغت (81%)، وللتأكد من درجة الإعتمادية في البيانات تم إستخدام إختبار ألفا كرونباخ، واستخدام أسلوب تحليل المسار ونمذجة المعادلة البنائية لإختبار الفرضيات. وحزمة برنامج التحليل الإحصائي (AMOSv25) في إجراء عملية التحليل العاملي التوكيدي للنموذج، وقد توصلت الدراسة إلى مجموعة من النتائج منها: أن هنالك أثر  عند مستوى دلالة  (α≤ 0.05)  للتسويق الريادي على الأداء المستدام، ووجود علاقة إيجابية بين التسويق الريادي بعدي (الإستباقية وتعظيم الموارد) والأداء المستدام بعدي (الأداء التنظيمي، والأداء الاقتصادي)، بالشركات الصناعية العاملية في ولاية الخرطوم ، وبناءاً على هذه النتائج أوصت الدراسة بضرورة زيادة الوعي بالتسويق الريادي من قبل الشركات الصناعية العاملة في ولاية الخرطوم وذلك لما له من آثار واضحة على الأداء المستدام لهذه الشركات وإستمراريتها.
Effectiveness of the Presidential Secondary School Bursary (PSSB) on Education of Orphans and Vulnerable Children in Selected Sub-Counties in Nairobi City County, Kenya
Authors:   Mount Kenya University, Kenya, Sanganyi Noah M. O, , Nyandoro Kepha , Ontita Edward Gizemba ,   University of Nairobi, Gakunga Harrison Ng’ang’a ,   Directorate of Children’s Services, Onyango Eric Ater ,   Masinde Muliro University of Science and Technology, Muhingi Wilkins Ndege ,   Pan Africa Christian University, Ndung’u Esther Mugure ,   Directorate of Children’s Services
Published: June 2023

The Presidential Secondary School Bursary (PSSB) was initiated as a complementary service to support Orphans and Vulnerable Children (OVC) in Secondary education in Kenya. However, there is limited evidence on the impact of the scheme on the enrolment, retention, and transition of OVC into higher and tertiary level education. This study examined the contribution of PSSB to the education of OVCs in Nairobi. The study anchored on the Theory of Socialist Economics of Education and Human Capital Theory. The study deployed a qualitative research design. Using purposive sampling, Nairobi County and Kasarani, Westlands, and Langata Sub-Counties were selected respectively. In each Sub-County, student beneficiaries, Principals, and Children’s Officers were the respondents. The sample size consisted of 7 students, 5 Principals, and 6 Children’s Officers selected using a purposive sampling method. In-depth interviews were conducted and data analysed using content and thematic analysis. The results show that the profile of student beneficiaries fit with the selection criteria of OVC benefitting from the scheme and that the PSSB was not adequate as most beneficiary absenteeism from schools was due to fee balances. Deserving students were left out due to non-observance of scheme procedures and guidelines. In terms of its impact, the beneficiaries’ psycho-social wellbeing was good leading to improvement in academic performance. The retention of students also improved. The study recommends an increase in the annual allocation of funds to the PSSB.
THE EFFECT OF WORK DISCIPLINE, WORK ENVIRONMENT AND WORK MOTIVATION ON EMPLOYEES’ PERFORMANCE AT THE PORT AUTHORITY AND HARBORMASTER OFFICE CLASS II TELUK PALU
Authors: Febrilita Febrilita , Thahir Harifuddin , Evvy Rossanty Niluh Putu
Published: June 2023

This study aims to analyze the effect of work discipline, work environment, and work motivation on employees’ performance at the Port Authority and Harbormaster Office Class II Teluk Palu. This study applied a survey type and causal descriptive using a research population of 80 civil servants at the Port Authority and Harbormaster Office Class II Teluk Palu where all employees are designated as research samples through the census method. The data analysis technique used multiple linear regression analysis. The result of this study indicates that work discipline, work environment, and work motivation variables simultaneously have a significant effect on employees’ performance at the Port Authority and Harbormaster Office Class II Teluk Palu, with a Sig-F value of 0.000 < α 0.05. The work discipline variable partially has a significant effect on employees’ performance at The Port Authority and Harbormaster Office Class II Teluk Palu with a Sig-t X1 value is 0.000 < α 0.05; The work environment variable partially has a significant effect on employees’ performance at The Port Authority and Harbormaster Office Class II PTeluk Palu with a Sig-t X2 value of 0.018 < α 0.05; and the work motivation variable partially has a significant effect on employees’ performance at the Port Authority and Harbormaster Office Class II Teluk Palu with a Sig-t X3 value is 0.029 < 0 α.05. Keywords: Work Discipline, Work Environment, Work Motivation, Employees’ Performance
THE INFLUENCE OF SERVICE QUALITY AND CUSTOMER VALUE ON INPATIENT SATISFACTION AT BHAYANGKARA HOSPITAL PALU CITY
Authors: Razak Abd , Miru Sulaeman , Santi Ira Nuriya
Published: June 2023

This study aims to determine the effect of service quality and customer value on inpatient satisfaction at Bhayangkara Hospital Palu City. The type of research was descriptive – verification. The research sample was inpatients at Bhayangkara Hospital Palu, which was determined by the purposive sampling method and totaled 105 patients. This study applied a multiple linear analysis method using SPSS software version 23. The results of this study indicate that (1) service quality and customer value have a significant effect on inpatient satisfaction at Bhayangkara Hospital Palu City, (2) service quality has a significant effect on inpatient satisfaction at Bhayangkara Hospital Palu City, ((3) customer value has a significant effect on inpatient satisfaction at Bhayangkara Hospital Palu City. Keywords: Service Quality, Customer Value, Patient Satisfaction
THE INFLUENCE OF LEADERSHIP AND MOTIVATION ON THE PERFORMANCE OF CIVIL SERVANTS AT PALU COURTHOUSE CENTRAL SULAWESI
Authors: Marpaung Darwis D , Miru Sulaeman , Hasanuddin Bakrie
Published: June 2023

This study aims to determine the influence of leadership and motivation, simultaneously influencing the employees’ performance at the Courthouse of Palu, Central Sulawesi and the influence of leadership partially on the employees’ performance at the Courthouse of Palu, Central Sulawesi. The population and sample in this study were the entire employees of the Courthouse of Palu, Central Sulawesi which were 60 people. The method of the study applied was descriptive through multiple regression analysis. The results show that leadership and motivation variables simultaneously have a significant influence on the employees’ performance of the Courthouses of Palu, Central Sulawesi, with an R-Square value is 0.611 on sig. 0.000. The leadership variable significantly influences the employees’ performance with a regression coefficient is 0.507 at sig 0.000; motivation notably influences the employees’ performance with a regression coefficient is 0.538 at sig 0.011.

Keywords: Leadership, Motivation and Performance
THE INFLUENCE OF THE GOVERNMENT'S INTERNAL CONTROL SYSTEM AND THE USE OF ACCOUNTING INFORMATION SYSTEMS ON THE QUALITY OF FINANCIAL REPORTS (AN EMPIRICAL STUDY ON THE RADIO FREQUENCY SPECTRUM MONITORING UNIT OF DIRECTORATE GENERAL OF RESOURCES AND EQUIPME
Authors: Syahriyani Syahriyani , Mattulada Andi , Fattah Vitayanti
Published: June 2023

This research aims to determine the effect of the Government's Internal Control System and the Use of Accounting Information Systems on the Quality of Financial Reports. The samples were taken through the saturated sampling (census) technique, a sampling technique from all population members, as many as 70 respondents. The data used are quantitative and qualitative, and the data sources used are secondary and primary data. The data analysis used in this research is multiple regression analysis. Based on statistical tests on the Government's Internal Control System and the use of Accounting Information Systems, it influences the quality of financial reports at the office of Radio Frequency Spectrum Monitoring Unit, Directorate General of Resources and Equipment of Post and Information Technology. The Government's Internal Control System partially influences the quality of financial reports at the office of Radio Frequency Spectrum Monitoring Unit, Directorate General of Resources and Equipment of Post and Information Technology. Accounting Information Systems partially influences the quality of financial reports at the office of Radio Frequency Spectrum Monitoring Unit of the Directorate General of Resources and Equipment of Post and Information Technology.

Keywords: Internal Control System, Accounting Information System, Financial Report Quality.
PENGARUH CELEBRITY ENDORSER DAN DISKON TERHADAP MINAT BELI KONSUMEN BYFIT
Authors: Rachmawati Alvy , Zulfahmi Ahmad
Published: June 2023

Penelitian ini bertujuan untuk menguji dan menganalisis pengaruh Celebrity Endorser dan Diskon Terhadap Minat Beli Konsumen Byfit baik secara parsial maupun simultan. Dalam penelitian ini populasi berjumlah 100 responden dan semuanya diambil sebagai sampel. Pengumpulan data melalui kuesioner, analisis data dalam penelitian ini menggunakan SPSS versi 23. Teknik pengambilan sampel menggunakan metode kuantitatif. Metode pengambilan sampel yang digunakan adalah teknik pengambilan sampel nonprobability sampling dengan jenis sampel jenuh. Pengujian data yang digunakan dalam penelitian ini meliputi uji validitas, uji realibilitas, uji asumsi klasik, analisis variabel berganda, koefisien determinasi, dan uji hipotesis. Hasil analisis menunjukan bahwa secara parsial dan simultan Celebrity Endorser dan Diskon berpengaruh positif terhadap minat beli konsumen Byfit.
PENGARUH KINERJA KARYAWAN MENGGUNAKAN METODE GRAPHIC RATING SCALE DAN 360 MANAGERIAL FEEDBACK TERHADAP PENJUALAN IKLAN (STUDI KASUS IKLAN DREAMSHOP DAN DIGITAL PRINTING TANGERANG)
Authors: Kusuma Feri , Hutapea Tigor
Published: June 2023

Tujuan penelitian ini adalah untuk mengetahui dan menganalisis pengaruh Kinerja karyawan dengan metode Penilaian Tradisional dan Umpan Balik Manajerial 360 terhadap penjualan advertising di PT. Dreamshop Advertising and Digital Printing yang berada di Tangerang. Metode penelitian yang dilakukan adalah penelitian asosiatif, dimana variabel diukur dengan skala likert. Metode pengumpulan data dilakukan dengan daftar pertanyaan (questionnaire). Populasi dalam penelitian ini adalah 40 Karyawan Dreamshop dan 30 orang dari pihak external Dreamshop. Penarikan sampel dengan metode purpose sampling atau yang bisa di katakan sample yang tertuju terhadap beberapa pihak. Dalam penelitian ini jumlah populasi relatif sedang yaitu sebanyak 70 orang. Pengolahan data menggunakan perangkat lunak SPSS versi 25, dengan analisis deskriptif dan pengujian hipotesis analisis regresi linier berganda. Hasil penelitian menunjukkan bahwa: (1) secara parsial variabel penilaian tradisional memiliki pengaruh positif tetapi tidak signifikan terhadap penjualan advertising dari PT. Dreamshop Advertising and Digital Printing; (2) secara parsial variabel umpan balik manajerial 360 memiliki pengaruh positif dan signifikan terhadap penjualan advertising dari PT. Dreamshop Advertising and Digital Printing; (3) secara simultan terdapat pengaruh yang positif dan signifikan antara variabel graphic rating scale dan umpan balik manajerial 360 terhadap penjualan advertising di PT. Dreamshop Advertising and Digital Printing.
Avanços conceituais em nutrição humana: ciência e tecnologia de alimentos
Authors: Sgarbieri Valdemiro Carlos
Published: June 2023

Este livro tem por objetivo descrever os avanços ocorridos nas áreas de tecnologia de alimentos e de nutrição humana durante o século XX até os dias de hoje. Novos paradigmas e conceitos foram estabelecidos a partir da segunda metade do século passado, particularmente em nutrição humana, com descobertas nos alimentos de compostos bioativos, até então considerados “não nutrientes”. O primeiro capítulo é uma descrição histórica dos principais avanços ocorridos e da importância das descobertas no período supracitado. Nos capítulos seguintes, é descrito e conceituado o que se convencionou chamar de compostos bioativos e nutrição funcional. Os últimos capítulos tratam de inovações em pesquisas, nas quais os conceitos de dieta funcional, nutrigenômica e nutrição personalizada são introduzidos. Esses conceitos poderão conduzir o leitor à seguinte indagação: Dieta ideal é um desafio atingível ou uma utopia? Para os pesquisadores parece ser mais um desafio inatingível, por se tratar de alcançar uma fronteira que se move constantemente pela pressão evolutiva.
Combined lineage tracing and scRNA-seq reveals unexpected first heart field predominance of human iPSC differentiation
Authors: Galdos Francisco X , Lee Carissa , Lee Soah , Paige Sharon , Goodyer William , Xu Sidra , Samad Tahmina , Escobar Gabriela V , Darsha Adrija , Beck Aimee , Bak Rasmus O , Porteus Matthew H , Wu Sean M
Published: June 2023

During mammalian development, the left and right ventricles arise from early populations of cardiac progenitors known as the first and second heart fields, respectively. While these populations have been extensively studied in non-human model systems, their identification and study in vivo human tissues have been limited due to the ethical and technical limitations of accessing gastrulation-stage human embryos. Human-induced pluripotent stem cells (hiPSCs) present an exciting alternative for modeling early human embryogenesis due to their well-established ability to differentiate into all embryonic germ layers. Here, we describe the development of a TBX5/MYL2 lineage tracing reporter system that allows for the identification of FHF- progenitors and their descendants including left ventricular cardiomyocytes. Furthermore, using single-cell RNA sequencing (scRNA-seq) with oligonucleotide-based sample multiplexing, we extensively profiled differentiating hiPSCs across 12 timepoints in two independent iPSC lines. Surprisingly, our reporter system and scRNA-seq analysis revealed a predominance of FHF differentiation using the small molecule Wnt-based 2D differentiation protocol. We compared this data with existing murine and 3D cardiac organoid scRNA-seq data and confirmed the dominance of left ventricular cardiomyocytes (>90%) in our hiPSC-derived progeny. Together, our work provides the scientific community with a powerful new genetic lineage tracing approach as well as a single-cell transcriptomic atlas of hiPSCs undergoing cardiac differentiation.
Intermediate filament network perturbation in the C. elegans intestine causes systemic dysfunctions
Authors: Geisler Florian , Remmelzwaal Sanne , Jankowski Vera , Schmidt Ruben , Boxem Mike , Leube Rudolf E
Published: June 2023

Intermediate filaments (IFs) are major components of the metazoan cytoskeleton. A long-standing debate concerns the question whether IF network organization only reflects or also determines cell and tissue function. Using Caenorhabditis elegans, we have recently described mutants of the mitogen-activated protein kinase (MAPK) SMA-5 which perturb the organization of the intestinal IF cytoskeleton resulting in luminal widening and cytoplasmic invaginations. Besides these structural phenotypes, systemic dysfunctions were also observed. We now identify the IF polypeptide IFB-2 as a highly efficient suppressor of both the structural and functional deficiencies of mutant sma-5 animals by removing the aberrant IF network. Mechanistically, perturbed IF network morphogenesis is linked to hyperphosphorylation of multiple sites throughout the entire IFB-2 molecule. The rescuing capability is IF isotype-specific and not restricted to sma-5 mutants but extends to mutants that disrupt the function of the cytoskeletal linker IFO-1 and the IF-associated protein BBLN-1. The findings provide strong evidence for adverse consequences of the deranged IF networks with implications for diseases that are characterized by altered IF network organization.
The impact of task context on predicting finger movements in a brain-machine interface
Authors: Mender Matthew J , Nason-Tomaszewski Samuel R , Temmar Hisham , Costello Joseph T , Wallace Dylan M , Willsey Matthew S , Ganesh Kumar Nishant , Kung Theodore A , Patil Parag , Chestek Cynthia A
Published: June 2023

A key factor in the clinical translation of brain-machine interfaces (BMIs) for restoring hand motor function will be their robustness to changes in a task. With functional electrical stimulation (FES) for example, the patient’s own hand will be used to produce a wide range of forces in otherwise similar movements. To investigate the impact of task changes on BMI performance, we trained two rhesus macaques to control a virtual hand with their physical hand while we added springs to each finger group (index or middle-ring-small) or altered their wrist posture. Using simultaneously recorded intracortical neural activity, finger positions, and electromyography, we found that decoders trained in one context did not generalize well to other contexts, leading to significant increases in prediction error, especially for muscle activations. However, with respect to online BMI control of the virtual hand, changing either the decoder training task context or the hand’s physical context during online control had little effect on online performance. We explain this dichotomy by showing that the structure of neural population activity remained similar in new contexts, which could allow for fast adjustment online. Additionally, we found that neural activity shifted trajectories proportional to the required muscle activation in new contexts. This shift in neural activity possibly explains biases to off-context kinematic predictions and suggests a feature that could help predict different magnitude muscle activations while producing similar kinematics.
Inhibition of type I PRMTs reforms muscle stem cell identity enhancing their therapeutic capacity
Authors: Dominici Claudia , Villarreal Oscar D , Dort Junio , Heckel Emilie , Wang Yu Chang , Ragoussis Ioannis , Joyal Jean-Sebastien , Dumont Nicolas , Richard Stéphane
Published: June 2023

In skeletal muscle, muscle stem cells (MuSC) are the main cells responsible for regeneration upon injury. In diseased skeletal muscle, it would be therapeutically advantageous to replace defective MuSCs, or rejuvenate them with drugs to enhance their self-renewal and ensure long-term regenerative potential. One limitation of the replacement approach has been the inability to efficiently expand MuSCs ex vivo, while maintaining their stemness and engraftment abilities. Herein, we show that inhibition of type I protein arginine methyltransferases (PRMTs) with MS023 increases the proliferative capacity of ex vivo cultured MuSCs. Single cell RNA sequencing (scRNAseq) of ex vivo cultured MuSCs revealed the emergence of subpopulations in MS023-treated cells which are defined by elevated Pax7 expression and markers of MuSC quiescence, both features of enhanced self-renewal. Furthermore, the scRNAseq identified MS023-specific subpopulations to be metabolically altered with upregulated glycolysis and oxidative phosphorylation (OxPhos). Transplantation of MuSCs treated with MS023 had a better ability to repopulate the MuSC niche and contributed efficiently to muscle regeneration following injury. Interestingly, the preclinical mouse model of Duchenne muscular dystrophy had increased grip strength with MS023 treatment. Our findings show that inhibition of type I PRMTs increased the proliferation capabilities of MuSCs with altered cellular metabolism, while maintaining their stem-like properties such as self-renewal and engraftment potential.
Loss of Ptpmt1 limits mitochondrial utilization of carbohydrates and leads to muscle atrophy and heart failure in tissue-specific knockout mice
Authors: Zheng Hong , Li Qianjin , Li Shanhu , Li Zhiguo , Brotto Marco , Weiss Daiana , Prosdocimo Domenick , Xu Chunhui , Reddy Ashruth , Puchowicz Michelle , Zhao Xinyang , Weitzmann M Neale , Jain Mukesh K , Qu Cheng-Kui
Published: June 2023

While mitochondria in different tissues have distinct preferences for energy sources, they are flexible in utilizing competing substrates for metabolism according to physiological and nutritional circumstances. However, the regulatory mechanisms and significance of metabolic flexibility are not completely understood. Here, we report that the deletion of Ptpmt1, a mitochondria-based phosphatase, critically alters mitochondrial fuel selection – the utilization of pyruvate, a key mitochondrial substrate derived from glucose (the major simple carbohydrate), is inhibited, whereas the fatty acid utilization is enhanced. Ptpmt1 knockout does not impact the development of the skeletal muscle or heart. However, the metabolic inflexibility ultimately leads to muscular atrophy, heart failure, and sudden death. Mechanistic analyses reveal that the prolonged substrate shift from carbohydrates to lipids causes oxidative stress and mitochondrial destruction, which in turn results in marked accumulation of lipids and profound damage in the knockout muscle cells and cardiomyocytes. Interestingly, Ptpmt1 deletion from the liver or adipose tissue does not generate any local or systemic defects. These findings suggest that Ptpmt1 plays an important role in maintaining mitochondrial flexibility and that their balanced utilization of carbohydrates and lipids is essential for both the skeletal muscle and the heart despite the two tissues having different preferred energy sources.
RBP-J regulates homeostasis and function of circulating Ly6Clo monocytes
Authors: Kou Tiantian , Kang Lan , Zhang Bin , Li Jiaqi , Zhao Baohong , Zeng Wenwen , Hu Xiaoyu
Published: June 2023

Notch-RBP-J signaling plays an essential role in the maintenance of myeloid homeostasis. However, its role in monocyte cell fate decisions is not fully understood. Here, we showed that conditional deletion of transcription factor RBP-J in myeloid cells resulted in marked accumulation of blood Ly6Clo monocytes that highly expressed chemokine receptor CCR2. Bone marrow transplantation and parabiosis experiments revealed a cell-intrinsic requirement of RBP-J for controlling blood Ly6CloCCR2hi monocytes. RBP-J-deficient Ly6Clo monocytes exhibited enhanced capacity competing with wildtype counterparts in blood circulation. In accordance with alterations of circulating monocytes, RBP-J deficiency led to markedly increased population of lung tissues with Ly6Clo monocytes and CD16.2+ interstitial macrophages. Furthermore, RBP-J deficiency-associated phenotypes could be genetically corrected by further deleting Ccr2 in myeloid cells. These results demonstrate that RBP-J functions as a crucial regulator of blood Ly6Clo monocytes and thus derived lung-resident myeloid populations, at least in part through regulation of CCR2.
Stock price movement prediction based on Stocktwits investor sentiment using FinBERT and ensemble SVM
Authors: Liu Jin-Xian , Leu Jenq-Shiou , Holst Stefan
Published: June 2023

Investor sentiment plays a crucial role in the stock market, and in recent years, numerous studies have aimed to predict future stock prices by analyzing market sentiment obtained from social media or news. This study investigates the use of investor sentiment from social media, with a focus on Stocktwits, a social media platform for investors. However, using investor sentiment on Stocktwits to predict stock price movements may be challenging due to a lack of user-initiated sentiment data and the limitations of existing sentiment analyzers, which may inaccurately classify neutral comments. To overcome these challenges, this study proposes an alternative approach using FinBERT, a pre-trained language model specifically designed to analyze the sentiment of financial text. This study proposes an ensemble support vector machine for improving the accuracy of stock price movement predictions. Then, it predicts the future movement of SPDR S&P 500 Index Exchange Traded Funds using the rolling window approach to prevent look-ahead bias. Through comparing various techniques for generating sentiment, our results show that using the FinBERT model for sentiment analysis yields the best results, with an F1-score that is 4–5% higher than other techniques. Additionally, the proposed ensemble support vector machine improves the accuracy of stock price movement predictions when compared to the original support vector machine in a series of experiments.
Financial Sustainability of Sorsogon State University: An Assessment
Authors: Niemo–Gamba Maryjean , Tabuena II Jose Winston
Published: June 2023

The study aimed to analyze the status of the financial sustainability of Sorsogon State University. Determining the extent of financial sustainability as viewed by the administrative staff and the faculty members along with the strategic financial planning, income diversification, and; administration and finance. This study utilized the null hypothesis and tested it with a significant level of 0.05 to measure the difference in the perception of the two groups of respondents. This study could assist the SUC's administrators in formulating policies regarding financial aspects to improve financial literacy and promote the value of transparency, accountability, responsibility, and trust. This descriptive research used documentary analysis and survey questionnaires to measure and analyze the financial sustainability status of Sorsogon State University from the fiscal year 2010 to 2012 along the three pillars of financial sustainability. From this result, an intervention in the form of an income or resource generation manual was proposed to serve as a guide/basis for implementing internally generated projects for Sorsogon State University. Following the findings of the study, it was established that Sorsogon State University has two main sources of budget and income that allow it to continue its operations: government allocations and income created internally by the university.
Needs for Discharge Education of Family Caregivers of Pediatric Patients: An Integrative Review
Authors: Lee Hyunjie , Lee Seung Eun , Lee Sang Hwa
Published: June 2023

Purpose: The purpose of this study was to explore needs for discharge education of family caregivers of pediatric patients through an integrated literature review.Methods: A systematic search was performed using four electronic databases (PubMed, CINAHL, Embase, and PsycINFO) guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analysis. Data were extracted, categorized, and analyzed using the thematic analysis method. The quality of each study reviewed was assessed using the Mixed Methods Appraisal Tools (MMAT).Results: In total, 10 studies that were published between January 2012 and December 2021 were included. The MMAT quality scores ranged from 60% to 100%. In this review, needs for discharge education were categorized into contents, methods, and materials.Conclusion: Pediatrics patients’ families wanted to receive clear and standardized discharge education using visual materials. In addition, they wanted to receive education in a separate place, without their children present, and with sufficient time. Thus, for effective discharge education, standardized educational methods should be developed, and visual materials, such as simulations and videos, should be used.
Effects of Virtual Reality Program on Glycated Hemoglobin, Static and Dynamic Balancing Ability, and Falls Efficacy for Diabetic Patients: A Systematic Review and Meta-Analysis
Authors: Yim Yi-Rang , Hur Myung-Haeng
Published: June 2023

Purpose: We aimed to confirm the effects of virtual reality programs used for patients with diabetes on reducing blood glucose levels and improving physical function.Methods: In this systematic literature review and meta-analysis, literature was collected from various databases for randomized controlled trials published in Korean, Chinese, and English by May 2021. The search yielded 1,243 studies. Eight studies were selected for the systematic literature review, and six studies were included in the meta-analysis.Results: In the eight selected studies, a non-immersive virtual reality programs were employed as the intervention method. The effect size of the virtual reality programs on glycated hemoglobin (HbA1c) was -0.40, with no significant difference between experimental and control groups. The effect size on static balancing ability was 1.04, and the effect size on dynamic balancing ability was 2.39. The effect size on falls efficacy was 0.69, and all functional outcomes differed significantly between the experimental and control groups (p<.05). A subgroup analysis of static balancing ability was performed according to the duration of the interventional virtual reality program. When the virtual reality programs lasting for more than six weeks, shows an effect size of 1.27 for static balance ability, which was statistically significant (Z=3.32, p<.001).Conclusion: Virtual reality programs for participants with diabetes did not reduce HbA1c, but improved balance ability and falls prevention efficacy. The virtual reality program is an effective method for diabetics to be interested and consistently self-care.
Influences of COVID-19 Knowledge, eHealth Literacy, COVID-19 Literacy, and Social Support on COVID-19 Preventive Behaviors among Foreign Students in Korea
Authors: Lee Eunmi , Kang Jeong Hee
Published: June 2023

Purpose: This study was conducted to identify the factors affecting coronavirus disease 2019 (COVID-19) preventive behaviors among foreign students in Korea.Methods: The study administered a descriptive cross-sectional survey to 201 foreign students. Data were collected from June 25 to July 6, 2022 using self-report structured questionnaires and analyzed using descriptive statistics and hierarchical regression analysis with SPSS for Windows version 27.0.Results: The participants were from China (n=58) or Vietnam (n=143), with a mean age of 22.28 years (SD=2.25 years) and length of stay in Korea of 13.94 months (SD=9.12 months). COVID-19 preventive behaviors were significantly different based on participants’ nationality (t=-3.31, p=.001), gender (t=2.05, p=.042), education level (t=-2.41, p=.017), and perceived health status (t=-4.46, p<.001), and were significantly correlated with COVID-19 knowledge (r=.17, p=.016), eHealth literacy (r=.33, p<.001), COVID-19 literacy (r=.22, p=.001), and social support (r=.26, p<.001). Hierarchical multiple regression analysis with those aforementioned variables explained approximately 16% of the variance in preventive behaviors.Conclusion: Based on the results of this study, it is necessary to find ways to improve eHealth literacy in order to create a safe environment for foreign students in Korea during outbreaks of infectious diseases such as COVID-19.
Habitat de inovação em biotecnologia – elementos que constituem o ambiente de inovação
Authors: Da Silva Gilson José , Amaral Creusa Sayuri Tahara
Published: June 2023

A biotecnologia é uma ciência que está em amplo desenvolvimento e vem se mostrando como uma das tecnologias de maior relevância para inovação. Nessa perspectiva, o presente trabalho tem como objetivo apresentar uma proposta de modelo de habitat para inovações em biotecnologia, que descreve os elementos que influenciam o processo de inovação nesses ambientes. A identificação desses elementos possibilita o planejamento das atividades do habitat de inovação com os parceiros e o adequado monitoramento dos resultados. A pesquisa foi baseada no método Design Science Research (DSR), amparada por uma revisão sobre os temas correlatos. A pesquisa oferece contribuições à literatura sobre modelos e centros de inovação, além de contribuições metodológicas relativas ao Design Science Research. Foi possível identificar os elementos relevantes para o habitat de inovação em biotecnologia, consolidados em um modelo de inovação. A política de inovação, integrada a um sistema de governança da inovação são fundamentais para que os demais elementos tenham sucesso, como os centros de inovação. Assim, espera-se que o modelo contribua para a estruturação dos habitats de inovação e sejam uma referência de apoio para a implantação de centros de inovação em biotecnologia no Brasil.
Influência das doenças parasitárias na produção de subsistência do pequeno produtor da agricultura familiar
Authors: Câmara Isadora de Menezes Brasil , Amora Sthenia Santos Albano , Queiroz Paulo Gabriel Gadelha , Alves Andressa Bandeira de Sousa , Bezerra Rebeca Colares , Macedo Renata Cristina Borges da Silva , Soares Karoline Mikaelle de Paiva , Bezerra Ana Carla Diógenes Suassuna
Published: June 2023

Os produtores da agricultura familiar são considerados uma classe específica no sistema social, visto que reúnem características das duas outras classes sociais, assim, ao mesmo tempo em que atuam como donos dos meios de produção também são trabalhadores. Nesse sentido o sistema de criação deve evitar erros de manejo sanitário para possibilitar uma maximização do lucro para os produtores. Dentre os erros mais comuns estão os que possibilitam as doenças parasitárias constituindo um dos principais entraves quando o manejo é inadequado. Portanto, o objetivo deste trabalho foi identificar a influência das doenças parasitárias na produção de subsistência do pequeno produtor da agricultura familiar. Foram visitadas 30 propriedades rurais escolhidas aleatoriamente na região Oeste Potiguar da zona rural do município de Mossoró, onde foi realizado um diagnóstico parasitário de endoparasitos (contagem de ovos por grama e larvas) e ectoparasitos. De acordo com o local e diagnóstico parasitários foram identificados ovos de Strongyloidea em 100% (30/30) das propriedades, Moniezia 23,3% (7/30) e oocistos de Eimeria 73,3% (22/30). As larvas identificadas por propriedade foram Haemonchus spp 90% (27/30), Trichostrongylus spp 86,6% (26/30), Oesophagostomum spp 20% (6/30) e Trichuris spp 3,3% (1/30). Quanto aos ectoparasitos foram identificados por locais de coleta em Damalinia caprae 46,6% (14/30) e Rhipicephalus microplus 10% (3/30). Concluindo que os produtores pesquisados apresentam criação de rebanhos caprinos com erros de manejo sanitário, ocasionando a presença de ecto e endoparasitos que podem influenciar nos baixos lucros associado a elevados gastos.
Suitability Evaluation of Pumpkin Seed Oil Biodiesel as a Possible Diesel for Zambia
Authors: Jimmy Daka J. , Muthali Aline Ishimwe , Simwatachela Hyden
Published: June 2023

The global concern about ways through which fuels, are free from greenhouse gases and other environmental contaminants has been growing. The solution can be achieved by producing fuels from renewable feedstock such as biodiesel which is marked as a non-greenhouse emission energy source. Biodiesel can be derived from natural sources such as vegetable oils, which have gained significant attention as a promising substitute for conventional diesel fuel. Fuel produced from biodiesel has a higher flash point above 70℃, a high viscosity of 4.692, and relatively low contaminants of 15.3 mg/Kg and a low residue count of 1.8%. The parameters rate fairly as desirable for use.
Effect of Integrated Nutrient Management on Growth and Yield Parameters of Maize (Zea mays.) (Poaceae)
Authors: Ramesh Bandla , ManvirKaur  , Chhabra Vandna
Published: June 2023

Aim: To study effect of integrated nutrient management on growth and yield of maize                 (Zea mays L.).

Study Design: A field experiment was conducted at Agronomy farm, school of agriculture, Lovely Professional University, Punjab, India during kharif season of 2022.

Methodology: The experiment trail was laid out in randomized block design. It consisted of three replications with ten treatment combinations i.e. T1- 100% Recommended dose fertilizers (RDF) + Farmyard manure(FYM)15 t ha-1;, T2- 100% RDF + Vermicompost7.5 t ha-1;, T3-100% RDF + seed priming with Biofertilizers (Azotobacter), T4- 75% RDF + FYM 11 t ha-1;, T5- 75% RDF + Vermicompost 5.6 t ha-1;, T6-75% RDF +seed priming with Biofertilizers (Azotobacter);,T7- 50% RDF basal dose + Nano urea spray 0.15% (25 and 50 Days After Sowing);, T8- 50% RDF basal dose + Nano urea spray0.30% (25 and 50 DAS);, T9- Vermicompost 3.5 t ha-1 + seed priming with Biofertilizers (Azotobacter); T10- control.

Results: The results showed that application of T2 100% RDF + Vermicompost 7.5 t ha-1 had significant effect on growth and yield of maize. The plant height, number of leaves per plant and dry matter accumulation were also significantly higher in T2followed by T1100% RDF + FYM 15 t ha-1. The highest grain yield (64.36 q ha-1) was obtained in T2 followed by T1 (63.6 q ha-1), T3 (57.92 q  ha-1) andT8 (56.16 q ha-1).

Conclusion: Overall, the results and the study suggest the use of integrated nutrient management can improve the growth and yield of maize and provide sustainable solution to meet the nutrient requirements of the crop.
Effect of Integrated Nutrient Management on Yield, Economics and Available Soil Nutrient of Kharif Sorghum (Sorghum bicolor L.)
Authors: Sallawar S. C. , Alse U. N. , Mane S. G.
Published: June 2023

The field experiment was laid out at Sorghum Research Station, VNMKV, Parbhani. Dist. Parbhani during kharif season of 2015 to study the “Integrated Nutrient Management in Kharif Sorghum (Sorghum bicolor L.)”. The experiment was laid out in randomized block design with three replications and variety CSH -16 as test crop along with nine (09) treatment combinations. The quantity of organic and inorganic fertilizer dose was calculated and applied in the plots as per the treatments. Sowing was done on 21th June 2015 by seeds are dibbling and distance between 45cm x 15 cm. The crop was harvested at physiological maturity and data on yield attributes and yield were recorded. The study revealed that the application of 75% RDN through inorganic fertilizer + 25% RDN through vermicompost + seed treatment with PSB + Azospirillum (T8) gave significantly higher   GMR (76,068  ha-1), NMR (37,999  ha-1) and B:C ratio (2.07) over rest of the treatments, however it was at par with application of 75 % RDN through inorganic fertilizer + 25% RDN through FYM + seed treatment with PSB + Azospirillum (T7).
Field Screening of Garlic Genotypes for Identification of Resistant Sources against Purple Blotch Disease
Authors: Vijaykumar K. N. , Kulkarni Shripad , Hiremath S. M. , Shashidhar T. R. , Kambrekar D. N. , Mahajan Vijay , Khar Anil , Patil P. V.
Published: June 2023

Garlic (Allium sativum L.) is one of the oldest cultivated plants in the world and belongs to the family Amaryllidaceae. Purple blotch caused by Alternaria porri (Ellis) Ciferri is one such disease which causes a great deal of loss for farmers. The best method to manage purple blotch is to adopt resistant genotypes for cultivation, which is highly necessary in areas with a high incidence. In order to identify resistant sources, 37 genotypes were field screened under artificial epiphytotic conditions at AINRPOG (All India Network Research Project on Onion and Garlic), MARS (Main Agricultural Research Station), Dharwad during Rabi, 2019 and 2020. Results from two years showed that no genotype was immune to purple blotch. Among the genotypes tested, five genotypes viz., G50, Bhima Purple, DOGR426, DOGR543 and DOGR569 were resistant to infection (1-10%), 17 genotypes moderately resistant to infection (11-20%), while 4 genotypes were moderately susceptible to infection (21-40%). On a scale of 0 to 5, only one genotype (HRG Local) showed susceptible (41-75%) in reaction. Among the remaining genotypes, disease reactions differed between years. The genotypes that are resistant can be utilized by breeders to produce high yielding purple blotch resistant varieties.
Artificial miRNAs derived from miR‐181 family members have potential in cancer therapy due to an altered spectrum of target mRNAs
Authors: Chira Sergiu , Ciocan Cristina , Bica Cecilia , Calin George A. , Berindan‐Neagoe Ioana
Published: June 2023

miRNAs are a class of noncoding RNAs with gene regulation properties, and they function as key factors in cell homeostasis. The interaction of miRNAs with their target mRNAs is largely considered to rely on sequence complementarity; however, some evidence indicates that mature miRNAs can adopt diverse conformations with implications for their function. Using the oncogenic miR‐181 family as a study model, we suggest that a potential relationship between the primary sequence and secondary structure of miRNAs may have an impact on the number and spectrum of targeted cellular transcripts. We further emphasize that specific alterations in miR‐181 primary sequences might impose certain constraints on target gene selection compared with the wild‐type sequences, leading to the targeting of new transcripts with upregulated function in cancer.