bluuebunny/crossref_metadata_2025 huggingface dataset:
ИЗМЕНЕНИЯ МИКРОБИОМА КОЖИ ПРИ АКНЕ: СОВРЕМЕННЫЕ ИССЛЕДОВАНИЯ И ПЕРСПЕКТИВЫ ПРИМЕНЕНИЯ В ТЕРАПИИ АКНЕПОДОБНЫХ ДЕРМАТОЗОВ
Authors: Оспанова А.М. , Кудабай А.У. , Сапаева Ф.А. , Сапаева К.А. , Копбай А.А.
Published: July 2024

Термин «микробиом» охватывает целый ряд микроорганизмов, включая бактерии, вирусы и грибы, их гены и метаболиты, а также окружающую их среду. Слово «микробиота» более ограничено и описывает группу комменсалов, симбиотических и патогенных микроорганизмов, обитающих в фиксированной среде. Количество микробных клеток, колонизирующих организм человека, в 10 раз превышает количество клеток человека. Помимо их количества, исследователи начинают понимать, что местные микробы кожи и кишечника жизненно важны для иммунологического, гормонального и метаболического равновесия хозяина [1,2]. Микробиом кожи выполняет защитную функцию, предотвращая колонизацию патогенами и поддерживая оптимальный уровень влажности в кожи. Это особенно важно для предотвращения различных кожных заболеваний и воспалительных процессов. Нарушение баланса микробиома может привести к различным кожным заболеваниям, таким как акне и акнеподобные дерматозы. Факторы, такие как неправильное питание, стресс и антибиотики, могут оказать негативное воздействие на состав и функции микробиома. Акне – это широко распространенное , хроническое воспалительное заболевание кожи, поражающее сальные железы. Все чаще считается, что взаимодействие между микроорганизмами кожи и иммунитетом хозяина играет важную роль в течение акне. Тогда как, у пациентов с акне обнаруживаются нарушения микробного состава и их активности в коже. Cutibacterium Acnes ( C. Acnes ; ранее называвшаяся Propionibacterium Acnes ) обычно встречается в областях, богатых кожным салом, и долгое время считалось, что ее чрезмерная пролиферация способствует заболеванию. Таким образом, исследование микробиома кожи не только расширяет наше понимание течения акне но и открывает новые перспективы в лечении.
СРАВНИТЕЛЬНЫЙ АНАЛИЗ АНАТОМО-МОРФОЛОГИЧЕСКОГО СТРОЕНИЯ КОРНЕВИЩА POTENTILLA BIFURCA L С НЕК ОТО РЫ МИ П РЕ ДС ТАВИТ Е ЛЯ МИ РОД А POTENTILLA L
Authors: Мурзалиева Г.Т. , Ануарова Н.М. , Хасенов Г.Т. , Ишмуратова М.Ю.
Published: July 2024

Лапчатка вильчатая (Potentilla bifurca L., семейство Розоцветные — Rosaceae) представляет собой многолетнее растение, 10-25 см высотой, с многочисленными почти-стелющимися побегами. Подземные органы данного вида обладают потенциально лекарственными свойствами, что может служит основой для практического применения данного вида лекарственного сырья. В ходе работы были проведены сравнительные исследования анатомо — морфологического строения корневищ 5 видов Potentilla (P.). На основании проведенных исследований определены диагностические признаки на макроскопическом и микроскопическом уровнях Potentilla bifurca L., произрастающего в Карагандинской области.
ШКАЛЫ-ОПРОСНИКИ CAT И MMRC ДЛЯ ВЫЯВЛЕНИЯ БОЛЬНЫХ С ХРОНИЧЕСКОЙ ОБСТРУКТИВНОЙ БОЛЕЗНЬЮ (ХОБЛ)
Authors: Есетова Г.У. , Идрисова Л.Р. , Салимова С.С. , Калдыбаева Г.
Published: July 2024

Актуальность: Европейское респираторное общество обозначило раннюю доклиническую диагностику и профилактику хронической обструктивной болезни легких (ХОБЛ) как одну из важнейших задач (GOLD, 2019) . ы Цель и задачи: Провести информационно-разъяснительную работу пациентам, выявить положительные и отрицательные отзывы влияющие на прогрессирование заболевании органов дыхания и распространенность курения путем использования анкетирования, доказать эффективность опросников CAT и MmRC. Материалы и методы исследования: По вопросам ранней диагностики и профилактики ХОБЛ, Дорожной карты пульмонологической помощи в РК на 2017-2019 годы», была проведена информационно-разъяснительная беседа в виде лекции и раздаточных материалов, с последующим анкетированием 30-ти пациентам терапевтического отделения Областной больницы г. Алматы. Из них мужчин-30. Их возраст составляет от 35 до 68 лет, в среднем — 42,8. Результаты и обсуждение: В результате проведенной беседы и анкетирование выявлено три категории пациентов. 1. Курящие и не имеющие представления о заболевании ХОБЛ-6 пациентов. (от 35-42 лет) баллы по САТ тесту посчитали до 10-ти. 2. Курящие и не имеющие представления о развивающихся признаков обструктивной болезни легких, но не имеющие клинических признаков -11 пациентов. (от 42-55 лет) баллы до 20-ти 3. Выявлены явные признаки заболевания респираторной системы, но при этом не имеющие желание бросить курить –у 13 пациентов. (их возраст составляет от 55-68 лет) баллы по САТ тесту показали до 30-ти. У всех последних 2-х групп людей, то есть 24 пациентов были признаки хронической обструктивной болезни легких. Выводы: 1. Широко использовать опросники врачами первичного звена здравоохранения для максимального снижения нагрузки на узких специалистов, учитывая высокую распространенность респираторных симптомов в популяции. 2. Использовать опросники, предназначенные для анкетирования пациента, а не для самостоятельного заполнения.
«ЖЕЛТАЯ КАРТА» В ПРАКТИКЕ ВРАЧЕЙ ДЕТСКИХ СТАЦИОНАРОВ
Authors: Исангужина Ж.Х. , Мусина А.З. , Кульдеева Г.А.
Published: July 2024

Актуальность. Безопасность больных детей не только важная медицинская, социальная и экономическая проблема, но также является важной составной частью национальной безопасности страны. Риски, связанные с возможными неблагоприятными реакциями на лекарственные средства (ЛС) у детей, подчеркивают актуальность необходимости более эффективного мониторинга Цель. Проведение анкетирования среди врачей для выявления уровня заполнения «Желтой карты» Материалы и методы. Исследование проводилось путем опроса 120 врачей, в сентябре 2023 г. на базе детских стационаров г. Актобе, по специально разработанной, валидированной анкете. Результаты. Наличие побочного действия лекарственного препарата в практике респондентов встречалось у 49%, не встречалось у 51 % врачей. Побочные реакции проявлялись в 30% случаев сыпью, 40% — жидким стулом, 9% — рвотой, 12 % — одышкой, 16% — отеками, 7% — судорогами, а 9% опрошенных отметили категорию «другие», такие как: заторможенность, боль в животе, кровотечение, гипертермия. В перечне групп препаратов, вызвавших побочные действия, отмечены: 40% случаев антибиотики, 15% противовирусные, 12% антипиретики, 22% сиропы от кашля, 7% случаев на нестероидные противовоспалительные средства и антикоагулянты, категория «другие» составило 4% (инфузионные растворы, витамины групп В). О форме 192-1/у (ЖК) знают от клинического фармаколога в 44%, из литературы 30%, от коллег 24% случаев, не знают и затрудняются ответить 2% случаев. На вопрос о важности заполнении ЖК 78 % респондентов ответили положительно, 5% отрицательно и 17% воздержались от ответа. Заполняют ЖК 39% врачей, не заполняют и не всегда заполняют 55 % и 6 % соответственно. Несмотря на то, что 78% респондентов отметили важность заполнений «желтых карт», на практике 55 % не заполняют карту сообщение. Заключение. Побочные действия ЛП встречаются в практике врача. Малое количество «желтых карт» не говорит об отсутствии побочного действия лекарственного средства, а скорее о недостаточном их заполнении. Неосведомленность врачей, «боязнь административных мер», «показаться некомпетентным» при заполнении карт сообщений нежелательной побочной реакции (НПР), требует проведения школ и семинаров в медицинских организациях
MORPHOLOGICAL CHANGES IN RAT SKIN AFTER THERMAL BURNS
Authors: Yessimsiitova Z.B. , Yeltay G.E. , Yestemirova G.A. , Kozhamzharova A.S. , Karbozova A.G. , Kydyrkhanova A.A. , Mombekov S.E.
Published: July 2024

Every day around the world, children and adults suffer from burn injuries. Burn injury is one of the global health problems due to its high prevalence and mortality. The skin is the largest multifunctional human organ. The area of the entire skin is on average 1.7-1.9 square meters. The skin has a wide variety of functions from protective to energy-saving and tactile. Burns have a long history, but new methods of study are needed, this is due to the increase in the frequency of burns in everyday life, production, as well as the complexity of the pathogenesis and treatment of burn disease. Pathological changes that occur in the body of burned animals lead to the fact that in the first hours with extensive burn injury, circulatory disorders occur in parenchymal organs, especially in the liver, lungs and adrenal glands. In the future, with severe intoxication, severe dystrophic processes occur in the muscles of the heart and other internal organs. Recently, the main areas of research into the pathogenesis of inflammation have become immunological, at the morphological level it has not been sufficiently studied. The article shows the morphological features of the study in thermal burns of the skin of rats during treatment with a different mechanism of action. Rats in the amount of 15 pieces were divided into 3 groups: the first control group with a burn without treatment, the second group with a thermal burn, to which levomekol gel was applied to the burn area, the third group was treated with powder from the medicinal plant yarrow Achillea millefolium L. On the 3rd, 7th, 14th, and 21st days, the rats were taken out of the experiment, after which the skin pieces were fixed in 10% formalin for further histological examination.
A Review On Optimization Of Process Parameters Of Weld Bead Using Taguchi Analysis For Steel 2062
Authors: Suman Aman Kumar , Chauhan Jagdip
Published: July 2024

Submerged arc welding is a type of welding process; it is mostly used in industry applications. Because of its efficiency and consistency in high production quality for welding. In this paper the optimization of process parameters for welding bead using Taguchi analysis, basically focusing on steel 2062. In this paper, the investigation on various parameters such as arc voltage, welding current, welding speed, wire diameter and granular flux, which are, affect weld quality and its properties. The complete review of literature related to submerged arc welding and its process parameters and optimization techniques. This review includes study of Taguchi method, fuzzy logic, artificial neural network and other optimization approaches that are used to enhance weld quality, characteristics and its mechanical properties. After optimizing process parameters, submerged arc welding shows advantages like high production rate, automation abilities and best qualities production. Form the conclusion highlights of submerged arc welding parameters to achieve desired mechanical properties and weld bead geometry, therefore, it is required to improve the efficiency of submerged arc welding for various industrial applications.
Experiencia familiar de agricultura urbana y manejo de residuos sólidos en el municipio de Emiliano Zapata, Veracruz, México
Authors: Abato Zárate Marycruz , Reyes Pérez Noel , Escalona Aguilar Miguel Ángel , Castillo Rocha Doris Guadalupe , Hernández Pérez Reyna Ruth
Published: July 2024

A nivel global existe preocupación por reducir la huella ecológica, generar estrategias de adaptación al cambio climático y lograr la seguridad y soberanía alimentaria. Las iniciativas locales en las zonas urbanas, como la promoción de huertos agroecológicos, contribuyen a lograr tales propósitos. El objetivo de este trabajo fue describir una experiencia familiar de Agricultura urbana y manejo de residuos sólidos en el municipio de Emiliano Zapata, Veracruz, México. Se aplicó un enfoque cualitativo, explorando y describiendo la experiencia objeto de estudio a través de una entrevista abierta, donde participa una familia de 4 integrantes. Se identifican tres etapas cronológicas en el desarrollo de esta experiencia: la etapa inicial (2001-2013), la etapa de integración a la red de agricultura urbana y periurbana de Xalapa-Veracruz (2014-2020), y la etapa de permanencia en casa derivada de la pandemia COVID-19. La separación de residuos sólidos se inicia a partir de 2001. Los residuos orgánicos se utilizan para producir abonos orgánicos mediante composteo y lombricomposteo, y los inorgánicos se clasifican en no reciclables y reciclables, estos últimos se llevan a centros de acopio o se utilizan para elaborar artesanalmente parasoles y revisteros. Entre las ecotecnias adoptadas está la captura agua de lluvia, con una captación de 24 m3 anuales; y la farmacia viviente, con más de 40 especies de plantas medicinales y aromáticas. En el huerto a través del tiempo se incrementó la agrobiodiversidad y se han implementado prácticas agroecológicas para el manejo de plagas. Otra actividad productiva es la cría de gallinas para obtención de huevo. El estudio constata que los beneficios de los huertos urbanos son multidimensionales, pues contribuyen a proteger la biodiversidad, son farmacias vivientes, preservan la memoria biocultural y son espacios de aprendizaje y de participación social. Los actores políticos deben promover iniciativas a favor de la agricultura urbana y periurbana.
Microplásticos en un ecosistema lagunar del trópico húmedo nicaragüense y su incidencia en poblaciones de Crassostrea rhizophorae
Authors: Ebanks Mongalo Billy Francis , Rivas Suazo Enoc Geremías , Siu Estrada Eduardo Alexander , Flores-Pacheco Juan Asdrúbal
Published: July 2024

El objetivo del estudio fue identificar microplásticos en agua, arena, sedimento y en la biota (Crassostrea rhizophorae) en la barra de Houn Sond, al sur de la laguna de Bluefields, Nicaragua. Dado que no existen estudios previos que permitan referenciar las afectaciones, este análisis proporciona datos fundamentales. Las muestras de agua se obtuvieron utilizando una red Bongo de 65 µm a una velocidad de 3 km/h, con tres réplicas; las de arena mediante un transecto sobre la línea costera de pleamar; el sedimento con una draga Van Veen de 6” x 6” pulgadas; y las de ostiones en bancos identificados al azar. La identificación de microplásticos se realizó mediante saturación de agua con cloruro de sodio y observación estereoscópica, mientras que las muestras de ostiones se analizaron por digestión química con H2O2 al 30%. De 1,296.073 m³ de agua filtrada, se identificaron 0.475 g de microplásticos y una partícula de goma de 0.022 g, siendo el color más abundante el blanco hueso con 0.329 g. En la arena se encontraron 23.282 g de microplásticos, con una mayor presencia del color blanco hueso (13.473 g). No se observaron microplásticos en el sedimento ni en las muestras de ostiones.
Assessment of antiurolithiatic activity of some herbal-fractions using in vitro techniques
Authors: Babita Rana  , Umera M Alvi
Published: July 2024

There is an extended inventory of medicinal plants used for urolithiasis due to their fewer side effects and because they contain copious phytochemicals that show advantageous effects in renal stones. The current research focuses on the in vitro evaluation of Trigonella foenum-graecum L., and Nigella sativa L., traditionally used in the treatment of urolithiasis by turbidity and titrimetric assay. Three different concentrations (1.0 mg/ml, 2.0 mg/ml, and 5.0 mg/ml) of the plant extracts were tested in each assay. The methanolic seed extracts of Trigonella foenum-graecum and Nigella sativa at 5.0 mg/ml exhibited a significant percentage of inhibition of calcium oxalate formation by turbidity method as well as percentage dissolution of calcium oxalate crystals by titrimetric method. The results of test groups displayed a near match to the standard drug Neeri used at 0.1mg/ml. This study has been primary evidence for Trigonella foenum-graecum and Nigella sativa as potential contributors to anti-urolithiasis.
Tinea capitis due to Microsporum canis in the ‎university hospital Hassan II of fez: ‎Epidemiological and mycological ‎profile
Authors: Kenza Bennani  , Mohammed Sekal  , Soukaina Adadi  , Zineb Tlamçani
Published: July 2024

Microsporum canis (M. canis) is a widespread zoophilic dermatophyte worldwide and is identified as the primary causative agent of scalp ringworm in prepubescent children. The objective of this study is to describe the epidemiological and mycological profile of scalp tinea due to M. canis diagnosed at the Hassan II University Hospital in Fes. This was a descriptive cross-sectional study conducted from January 1, 2016, to December 31, 2023, involving all patients referred to our parasitology-mycology laboratory for scalp mycological sampling, excluding those already under antifungal treatment. Out of a total of 251 patients, 72 patients were confirmed to have scalp ringworm based on fungal culture (28.68%). Among the positive samples, 33 cases were confirmed as M. canis positive (45.83%). The mean age of patients with M. canis scalp ringworm was 8.75 years, with a predominance (63.63%) in children aged 5 to 10 years. The male-to-female sex ratio was 1.35. A history of contact with animals was found in 60.6% of cases, and immunosuppression was noted in 3.03% of cases. The tinea capitis presenting as large alopecic patches was exclusive to the 33 patients. Direct examination was positive in 66.66% of cases, showing an endo-ectothrix pattern of hair parasitism in all cases. Our study confirmed the predominance of M. canis scalp ringworm in school-aged male children and its rarity in adults, consistent with the literature, particularly studies from Tunisia, Cameroon, and Germany.
Innovations in fixed asset management: Enhancing efficiency through advanced tracking and maintenance systems
Authors: Patience Okpeke Paul  , Jane Osareme Ogugua  , Nsisong Louis Eyo-Udo
Published: July 2024

This paper explores the transformative impact of advanced tracking and maintenance systems on organizational efficiency and asset management practices. It examines key technological innovations such as RFID, GPS, IoT integration, AI-driven predictive maintenance, and CMMS platforms. These technologies enable organizations to enhance operational efficiency by reducing downtime, optimizing asset utilization, improving lifecycle management, and ensuring accurate tracking and reporting. Despite the benefits, implementing these systems poses challenges, including technical complexity, initial financial investment, and data security and privacy concerns. However, AI and machine learning advancements offer opportunities to mitigate these challenges by predicting asset failures and optimizing maintenance schedules.
Resistência à punção de ligações laje-pilar com aberturas simétricas e reforço ao cisalhamento: comparativos de prescrições normativas
Authors: Santos Júnio Carvalho dos , Melo Guilherme Sales Soares de Azevedo
Published: July 2024

Na construção civil contemporânea, as ligações laje-pilar desempenham um papel crucial, especialmente em sistemas de concreto armado sem vigas. Esses sistemas são altamente valorizados por otimizarem o pé-direito e oferecerem maior flexibilidade no layout interno dos edifícios. No entanto, eles também apresentam uma susceptibilidade à ruptura frágil por cisalhamento do concreto na região do pilar, um fenômeno conhecido como punção. Este estudo se propõe a investigar a resistência à punção em lajes lisas de concreto armado. O foco está particularmente em situações que exigem aberturas próximas aos pilares para acomodar instalações complementares. Para isso, foram analisadas as prescrições de cálculo das normas NBR 6118:2023, ACI 318-19, Eurocode 2 e fib Modelcode 2010. A análise comparativa dessas normas revelou diferenças significativas em como cada código aborda as ligações laje-pilar internas com duas aberturas simétricas adjacentes ao pilar, tanto com quanto sem armadura de reforço ao cisalhamento. Os resultados principais indicam que o perímetro externo proposto pela NBR 6118:2023 e pelo Eurocode 2 limita teoricamente a resistência das ligações reforçadas com armadura em cruz. Em situações ideais, essa resistência é cerca de 30% superior à resistência de uma ligação similar sem reforço. No entanto, ao se utilizar estribos fechados comuns, essa resistência é apenas 17% superior à resistência sem armadura. Isso limita a aplicabilidade prática do estribo. Além disso, o estudo também analisa outras situações de posicionamento de armaduras, tanto com quanto sem a presença de armaduras e aberturas. Essa análise abrangente fornece uma visão valiosa sobre a eficácia e as limitações das ligações laje-pilar na construção civil moderna.
Políticas de dividendos no Brasil: um modelo pedagógico de apoio à decisão
Authors: Ambrozini Marcelo Augusto , Pimenta Junior Tabajara
Published: July 2024

O objetivo deste trabalho é apresentar a proposta de um modelo de apoio à decisão de dividendos que leve em consideração fatores como a geração de valor econômico ao acionista, as particularidades legais e tributárias brasileiras, o poder de distorção da inflação na formação do lucro contábil, a estrutura ótima de capital da empresa, a existência de projetos futuros com valor presente líquido positivo, o fluxo de caixa livre para o acionista e outros fatores não considerados pelo Modelo de Dividendos Residuais (MDR). O modelo de apoio à decisão de dividendos aqui proposto parte da premissa de que a decisão sobre a distribuição ou retenção de lucros deve ser iniciada pela ótica da capacidade de geração de riqueza por parte da empresa. Com base nisso, o modelo é dividido em dois grandes ambientes. Um deles será chamado de “ambiente de retenção de lucros” enquanto o outro denominado “ambiente de distribuição de lucros”. O que direciona a decisão dos dividendos para um ou outro ambiente é a geração de valor econômico ao acionista. Além de fornecer um mapa conceitual para apoio à decisão de dividendos, algumas considerações são feitas aos gestores com relação à forma de devolução de fundos aos acionistas e também com relação aos aspectos comportamentais que envolvem a decisão de alterações nas políticas de dividendos. Ao parametrizar a decisão dos dividendos pela lógica financeira da maximização da riqueza dos acionistas, o modelo permite que o gestor justifique sua decisão de retenção ou de distribuição dos lucros. Isso pode ajudar inclusive a fornecer as bases para a elaboração do relatório anual no tocante às justificativas apresentadas pelos gestores na sua decisão de dividendos.
Validação de questionário para análise da identidade de estudantes de Medicina: relato de experiência
Authors: Oliveira Márcia Farsura de , Chacham Alessandra Sampaio
Published: July 2024

O artigo relata a experiência do processo de pré-testagem do instrumento de pesquisa questionário, explorando suas adaptações e validações preliminares para garantir a confiabilidade e a eficácia na coleta de dados. Seis estudantes de Medicina foram selecionados para avaliar o questionário utilizando uma escala Likert. O processo envolveu adaptação inicial, piloto e análise das sugestões dos avaliadores. O questionário obteve um alto nível de concordância (97,5%) entre os avaliadores. Os termos que foram considerados confusos, e questões impraticáveis para estudantes do primeiro ano foram revistos. As intervenções resultaram em um instrumento mais claro e aplicável. As descobertas destacam a importância de uma abordagem cuidadosa na criação de questionários para pesquisas em educação médica. Além disso, o estudo ressalta a importância da continuidade da pesquisa sobre as influências externas na formação da identidade médica, uma vez que pode fornecer diretrizes valiosas para a melhoria contínua dos currículos de Medicina. O aprimoramento de programas de ensino médico possibilita a formação de profissionais tecnicamente competentes, sensíveis às demandas sociais e capazes de atuar de forma ética e responsável.
Herança digital: a integração do acervo digital ao patrimônio à luz das regras sucessórias do Ordenamento Jurídico Brasileiro
Authors: Santos Paulo Henrique Oliveira dos , Delmondes João Paulo Sales , Alencastro Maria Fernanda Borges Daniel de
Published: July 2024

Este estudo se cinge à análise dos casos práticos e doutrinários, frente à integração do patrimônio digital ao direito sucessório, tendo em vista não haver uma norma regulamentadora responsável para solucionar os conflitos existentes no mundo fático, e, assim, criam-se lacunas jurídicas. Para tal, foi utilizado o método de revisão bibliográfica, documental e jurisprudencial, a partir da linha de pesquisa Função Social do Direito e Interculturalidade, na subárea Direito e Mudanças Sociais. Nessa intenção, o objetivo foi analisar a incorporação do acervo digital ao patrimônio, mediante as regras sucessórias no ordenamento jurídico brasileiro, haja vista a mutabilidade do conceito de bens, a partir do momento em que os meios digitais se tornaram protagonistas nas atividades humanas, e assumiram o papel que antes era exclusivo do mundo físico. O estudo demonstrou a diferença de bens e como eles podem ser abordados, tanto digitais existenciais quanto patrimoniais. Analisou-se, também, a aplicabilidade das regras sucessórias nos bens digitais e se buscou entender a aplicabilidade diante das constantes evoluções tecnológicas da sociedade, verificando-se a possibilidade da transmissão post mortem. Os casos examinados evidenciam que as decisões, mesmo em casos similares, são controversas, sendo indicada pela doutrina a produção testamentária na observância da expressa manifestação de vontade pela transmissão desses ativos digitalizados. Por fim, concluiu-se que, embora o testamento não ocorra na maioria dos casos, é evidente a necessidade de uma norma efetiva para regulamentar a sucessão dos bens digitais da pessoa falecida, a fim de que não existam lacunas e indefinições.
“Held from the Mainland”: Political Deportation, Detention, and Immigrants’ Rights during the Cold War
Authors: Chen Michelle
Published: July 2024

Throughout the 1950s, as anti-communism shaped immigration law, the Los Angeles Committee for the Protection of Foreign Born developed a leftist rhetoric of immigration justice that cast the quest for equal justice for the foreign-born as a test for the integrity of democracy and the Bill of Rights. While the group was marginalized by the anti-communist crackdowns of the postwar era, it managed to create a unique multi-racial, multi-ethnic coalition and crafted a rhetoric that knitted together ideas of migration as a basic right, universal due process, free speech for all non-citizens, and deportation as an inhumane and politically repressive state intervention.
Overview of Trauma Injuries Caused by Traffic Accidents in Baixada Santista, Brazil
Authors: Rocha Luís Fernando Rosati , Rocha Ana Paula de Carvalho Miranda Rosati , Sobral Ana Paula Taboada , Gallo Juliana Maria Altavista Sagretti , Silva Nathálie Beatriz do Carmo , Bussadori Sandra Kalil , Martimbianco Ana Luiza Cabrera , Mendes Gustavo Duarte , Santos Elaine Marcílio , Gonçalves Marcela
Published: July 2024

Background: In Brazil, traffic accidents have been on the rise. There is a very high social and economic impact in the country, either by the direct sequelae that are left by the trauma, or by the deaths caused by it. Objective: This study aims to analyze the medical care associated with traffic accident-induced trauma in Baixada Santista, a Brazilian region comprising nine cities (six of which were included in this paper), along with the causes and consequences of such incidents for the population. Methods: For data collection, DATA SUS BRASIL, which is a governmental website, was used. The impact that trauma causes on people and the main bodily injuries produced in them, the most affected groups and the cities of the Baixada Santista where the accidents occurred were collected. The data were analyzed using descriptive statistics / relative frequencies. Results: The analysis reveals that young men, particularly those who ride motorcycles, are most susceptible to traffic accidents. In relation to the cities of the Baixada Santista, we verified that the city of Santos emerges as the primary location for these accidents, primarily due to its substantial motorcycle fleet. Conclusions: There is a pressing need to implement preventive measures targeting young male motorcyclists in this region. It is through awareness that it will be possible to act in the prevention of accidents and reinforce to the public power, not only the need for consciousness, but also the importance of qualifying the nurses and professionals involved in the treatment and rescue of victims.
MATERNAL AND FETAL HEALTH CHALLENGES IN HEPATITIS E-INFECTED PREGNANCIES
Authors: HUSSAIN J , NOOR N , REHMAN F , ILYAS A , TOFAIL S
Published: July 2024

The emergence of Hepatitis E virus (HEV) infection presents a mounting apprehension in less developed areas. When contracted during pregnancy, this infection instigates dire ramifications, posing grave threats to the well-being of both the expectant mother and the developing fetus. Notably, HEV accounts for a substantial fraction of maternal fatalities, encompassing a range of 19% to 25%, while also contributing to a noteworthy 7-13% of neonatal deaths. The primary objective of this study is to delve into the intricate relationship between HEV infection and the ensuing consequences for maternal and fetal health during pregnancy. Objectives: To explore the e maternal and fetal outcomes in pregnant women with Hepatitis E. Methods: A prospective study design was implemented, and 160 pregnant women were enrolled. The study was conducted at a tertiary healthcare facility over the period spanning from April 2021 to September 2022 after fulfilling the inclusion criteria and consent form. The collected data were entered and analyzed by using SPSS version 23. Results: A total of 160 pregnant women enrolled in this study, the mean age 30.90±7.323 (Age Range 18-44); gestational age was divided into two groups  ≥  36 weeks  77(48.1%) compared with ≥ 36 weeks as 83(51.9%).The frequency distribution of table -2 showed postpartum hemorrhage 82(51.2%), disseminated intravascular coagulation 70(43.8%) and hepatic encephalopathy 46(28.8%). The mode of pregnancy termination due to hepatitis E virus infection showed induction of labor 64(40%), hysterectomy 111(69.4%), and dilation and evacuation (D&E) 84(52.5%). While comparing maternal HEV infection with other research variables, it was observed that there was a significant difference found in HEV-positive pregnant women and low birth weight (< 2500g), fetal scalp monitors during delivery, and hysterectomy as p-value < 0.05. Conclusion: A high mortality rate was evident in hepatitis E virus infection-affected pregnancies in this study. There is a need to educate pregnant ladies regarding preventive measures to avoid fulminant consequences. Emphasis should be given to following hygienic practices during pregnancy, and proper antenatal visits should be mandatory to educate the women.
EVALUATION OF CHICKPEA VARIETIES FOR CLIMATE RESILIENCE AND YIELD STABILITY AT DIFFERENT PLANTING DATES
Authors: RASOOL I , HUSSAIN K , AMEEN MA , BATOOL A , ANAM M , AZIZ A , HUSSAIN A , MAHMOOD MT , MAQSOOD Z , AHMAD RT , SAMAD RA
Published: July 2024

The study was conducted to check the impact of variable date of sowing for climate resilience in two consecutive years 2021-2022 and 2022-2023 at Faisalabad. Three different dates of sowing 25th of October, 10th, and 20th of November were selected for screening of sixteen Desi chickpea, genotypes, and commercial variety Bittal-2016 as check. Data were recorded for days to 50% flowering, plant height, primary and secondary branches, pods per plant, 100-grain weight, and grain yield kg/ha. The highest grain yield per ha in both years was produced by D-20004 and D-20007. The comparison of sowing dates manifested that on 25th October the plant health remained good and was less affected by climate and produced enhanced grain yield. On the 10th of November and 20th of November, plant growth remained stunted and bear the low number of pods per plant ultimately producing a low yield. The selected lines can be used in breeding programs for the development of climate-resilient chickpea genotypes.
Unleashing the potential: Exploring the ubiquitin-proteasome system as a potential treatment for the Alzheimer's disease
Authors: Yan Wuji , Zhang Jinfan
Published: July 2024

Alzheimers disease (AD) is a neurological disorder that causes the buildup of amyloid-beta plaques and neurofibrillary tangles in the brain. One key mechanism designed to mitigate the buildup of these misfolded proteins is the ubiquitin-proteasome system (UPS). In healthy individuals, the UPS marks these amyloid-beta plaques and neurofibrillary tangles with ubiquitin markers, facilitating their subsequent degradation by the proteasome complex. The UPS is critical for the degradation of the proteins, and its dysfunction has been observed in AD. In this paper, a potential treatment for diminishing dysfunction of the ubiquitin-proteasome system is composed for Alzheimers disease individuals. This research paper explores the correlation between impaired UPS and AD, focusing on its role in degrading damaged proteins. The paper also collects evidence suggesting that enhancing the ubiquitin-proteasome system can have a positive impact on clearing amyloid-beta plaques and neurofibrillary tangles. Additionally, potential UPS-based treatments for AD, such as PA28 activators and natural compounds, are investigated.
Exploring combined therapeutic strategies: S-adenosylmethionine (SAM) and conventional medications in polycystic ovary syndrome (PCOS) management
Authors: Cao Yaoyuan , Wen Xuanang , Lin Yihong
Published: July 2024

Polycystic Ovary Syndrome (PCOS) remains a prevalent endocrine disorder among women of reproductive age, with treatments often facing significant limitations. This research article delves into an innovative therapeutic strategy that bridges the potential epigenetic capabilities of S-adenosylmethionine (SAM) with the established benefits of traditional PCOS medications, notably metformin and contraceptive pills. Drawing inspiration from contemporary literature, the manuscript highlights the limited role of SAM in DNA methylation processes and the unclear long-term effects of Sam in attenuating PCOS-related traits in specific animal models. The paper meticulously outlines an experimental design, encapsulating aspects such as precise drug formulation, systematic administration regimens, and methodical data collection and analysis techniques. Such a holistic approach facilitates a robust evaluation of the synergetic effects of combining SAM with established drugs. In spotlighting this combined therapeutic method, the article aspires to offer fresh perspectives in the realm of PCOS management, ultimately emphasizing the pivotal importance of subsequent clinical trials and more extensive studies in solidifying these preliminary findings.
Expression of gene CG13427 in Drosophila embryo and its regulation by the transcription factor Zelda
Authors: Wang Zixuan
Published: July 2024

This study focuses on the moiety influencing gene expression in Drosophila embryonic development, including RNA polymerase II, transcription factor (TF) Zelda, and interactive neighboring genes. The CG13427 gene in Drosophila was used as an experimental model. Chromatin Immunoprecipitation (ChIP) was conducted to examine the DNA sequence targeted by Polymerase II and Zelda at different time points. Since previous evidence indicates that Zelda may play a key role in activating the zygotic genome, a well-controlled experiment here was designed to investigate whether the expression of adjacent genes would be interrupted if Zld-binding sites in one gene are abolished hence determining the correlation. Based on the research works done by Y. Ma and Rushlow (unpublished data), the exact binding site of Zelda in the CG13427 was found at the CAGGTAG motif. Therefore, a series of experiments were designed to investigate how Zelda affects the expression of CG13427 in Drosophila embryos. Validation experiments were subsequently designed using gene editing tools to abolish CAGGTAG when the mutation was introduced to further verify the previous findings.
Association between screen usage and two core symptom changes in children with autism during Covid-19: A study in Italy
Authors: Luo Yihan , Cui Jiayi
Published: July 2024

As a result of covid-19, children with autism have experienced a substantial increase in screen time at home. This study delves into a dataset from Italy, exploring the impact of the severity of a child's doctor's diagnosis of autism on the child's choice of online activities and on the improvement of social interaction and behavioral problems. Results showed that television viewing was most strongly associated with these core symptoms, and that most children with varying severity of symptoms showed some improvement in social interaction and behavioral problems through watching TV.
Streptococcus pneumoniae: Virulence factor, pathogenesis, and two typical drugs with distinctive mechanism
Authors: Yue Lifan
Published: July 2024

Streptococcus Pneumoniae is one of the major respiratory pathogens. It causes respiratory tract infection, Otitis media, meningitis, septicaemia, and other diseases, which can develop fast and become life-threatening in several days if left untreated. This gram-positive bacterium has toxic cell wall and secreted proteins, invading human body when the immune system is weak. One common treatment against S. Pneumoniae is through Augmentin, the combination of amoxicillin and clavulanic acid. The former is an -lactam antibiotic, which kill the cells by binding to PBPs and arrest cell wall synthesis, while the latter is an -lactamase inhibiter frequently combined with -lactam antibiotics, as a countermeasure of developing antibiotic resistance. Another drug is Azithromycin, a macrolide antibiotic, works by binding the 50S subunit in the bacterial ribosome and partially blocks NPET, a channel for newly synthesized peptides to leave. The drugs in this family have a specificity on amino acid sequence, rather than simply block and stop translation thoroughly.
Explore the impact of the use of two different odors in training on the behavioural and neuroanatomical of reversing intergenerational stress in mice
Authors: Zhu Fangjie , Gu Jiani , Lin Lang , Zhang Weitong
Published: July 2024

Current research has indicated that stress from relatives affects not only relatives but also their offspring, and that therefore, effective intergenerational genetics to prevent stress would be beneficial to public health, while odor-based fear adjustment provides a way to address the problem. So our research is aimed at examining the intergenerational genetic trauma and stress. We adjusted the odor fear of F0 mice before they were conceived, and we trained F0 mouse with two different odors (cumin and cinnamon). We expose mice in a particular group of experiments to a specific odor (cumin or cinnamon) and train them to associate the odor with current stimulation (conditioning). At the same time, we will also help mice to eliminate their fear of extinction in a way that shows only the smell after the conditioning training of other specific groups of mice. We then performed behavioral and neurosynthesis tests on F0 offspring of F1 mice under different conditions, with specific smell and no specific odor (two of which were used to train F0 mice), and tested the egg cells of offsprings of females. We hope to use the findings to further explain the previously undetected methods of intergenerational stress genetic reversal, further explaining how environmental information, as well as multiple environmental data, are transgenetic at the behavioral, neuro-anatomical and epigenetic levels. This will further reveal the potential for extinction training to be applied to family training to reverse the impact of family stress sources on offspring.
Restoring the acidifying function of lysosomes for Alzheimer's disease therapy
Authors: Zhou Xinyan , Xie Yile , Li Xiang , Cao Yixuan
Published: July 2024

Alzheimers disease, abbreviated as AD, is a clinical syndrome that often occurs in the elderly, characterized by progressive deterioration of memory and cognitive function. The disease usually manifests gradually, following a slow and irreversible progression. It leads to brain atrophy and eventual cell death. Recent research suggests that Alzheimers disease may result from nerve cell death followed by the appearance of extracellular amyloid plaques. This study will focus on lysosomal acidification disorders, which lead to lysosomal rupture and subsequent cell death. The abnormal acidic environment in lysosomes is mainly due to the increase in pH value and the loss of activity of V-ATPase. This work will investigate the potential of pharmacological agents and nanoparticles to restore lysosomal acidification by enhancing V-ATPase activity and lowering pH levels. The research demonstrates that nanoparticle-based and pharmacological methods hold promise for addressing the dysfunction in lysosomal acidification, a key issue in Alzheimers disease.
A review of research status of self-healing hydrogels for treating a diabetic wound
Authors: Chan Pengshan , Zhang Jiatong , Zhang Ruoqing
Published: July 2024

Diabetes presents a challenge in wound healing management due to its propensity to lead to chronic non-healing wounds and injuries. Due to neurotherapy and dysfunction of the immune system, impaired wound sensation is caused. Over time, such factors hinder wound detection and create a condition prone to infection and inflammation. Consequently, these wounds demand specialized interventions for successful resolution. Self-healing hydrogels appear as a solution, possessing the remarkable ability to autonomously repair damage sustained during use, mimicking the regenerative ability of native tissues. These advanced materials offer extensive benefits in wound management. Their rapid restoration of the structure upon mechanical disruption ensures prolonged contact with wound sites, maintaining an optimal healing environment. This review explores the current advances made in self-healing hydrogels as an effective and efficient biomaterial through their properties for addressing these challenges in diabetic wound treatment. With wound dressings playing an important role in promoting healing and preventing infections, this review focuses on self-healing hydrogels potential to revolutionize wound care practices.
Effect of Arc gene on intergenerational memory
Authors: He Tianyi
Published: July 2024

Recent studies have revealed that parental exposure to environmental stimuli could induce epigenetic modifications that affect gametes, pass on to offspring, and affect the phenotype of several later generations persistently. This is a phenomenon known as trans-generational memory. The VLPs encoded by Cer1 retrotransposon in C. elegans has been shown to be crucial for trans-generational transmission of learned avoidance behaviour memory, which is propagated and functions via germlines. Arc is a neuronal gene that similar to Cer1, encoding a protein involved in consolidation of animal memory. Here, we hypothesized that Arc and Cer1 shared a similar mechanisms and RNA in Arc VLPs can be spread by germline. GAG is a retroviral protein also encoded by Arc gene, mediating RNA transfer between nerve cells. Therefore, four experiments on mice are designed in this paper in order to confirm the hypothesis above and investigate the functions of GAG protein in trans-generational memory, namely (1) dependency of Arc in intergenerational memory, (2) if there is Arc expressed in sperm, (3) the specific RNA sequences that involved in the process, and (4) the role of the GAG protein.
Assessment of cellular signaling pathways in cancer: Targeting aberrant kinases and phosphatases for personalized therapy
Authors: Mao WangHao
Published: July 2024

Cancer is a group of diseases where cell proliferation is uncontrolled leading to formation of tumors which can spread to other parts of the body in a process called metastasis. With a mortality of about ten million deaths each year, cancer is responsible for one in six deaths which makes it one of the leading health problems worldwide. Because of this it is necessary for scientists to research cancer thoroughly to stop this problem as soon as possible. Cellular signaling pathways regulate cell proliferation, depending on the ligand that binds to cells it can lead to cell growth or apoptosis. So if a mutation happens in one of these pathways it can lead to serious problems such as the constant activation of the pathway causing uncontrolled cell growth and thus, cancer. In this review, I will focus on the aberrant kinases and phosphatases describing their pathways with detail and seeing how to target these mutations using combinatorial therapy with signal-transduction inhibitors to try to stop the pathogenesis of cancer. So far, there is no known cure for cancer and only some treatments in phase III are available. Trying to cure cancer is very complex, especially in cancer treatment as each patient may have genetic variations, the molecular profile of the tumor, and other unique biological characteristics, herein, personalized therapy based on different patients situation to increase treatment effectiveness while minimizing side effects. In this review, we intend to elucidate the significance of targeting aberrant kinases and phosphatases in the pathogenesis of cancer.
LNPs as delivery platform of Rituximab for SMZL
Authors: Huang Zhengnong , Tang Zifu , Zhang Xianwen
Published: July 2024

Splenic Marginal Zone Lymphoma (SMZL) is a low-grade B-cell non-Hodgkin lymphoma from which patients may suffer anemia, autoimmune disorder and splenomegaly respectively. Due to its chronic nature, it has been increasingly hard to identify and treat effectively. The study establishes an SMZL mouse model and explores the potential of enhancing Rituximab treatment using Lipid Nanoparticles (LNPs). Designed experiment includes how to establish the NFS.N mice model, characterization of the disease on mice and recovery standard of mice. First, SMZL mice model is establish followed by histology and immunocytochemistry investigation which looks directly at the mices lesion. Then flow cytology is carried out which looks at the expression level of IgM, IgK, CD23, CD45 etc., before bone marrow infiltration is carried out. A controlled experiment of three groups of mice is designed, including mice treated with conventional Rituximab, delivery with LNPs and delivering empty LNPs, respectively. The effect of LNPs on treating mice SMZL is investigated. And some expected results and analysis methods were also discussed alongside with recovery standard. This experiment aims to provide theoretical support to the development of more effective and targeted therapies for this specific type of lymphoma. However, this is only an design rigorous experimentation strengthens the scientific validity of these findings.
Zelda regulates expression of slam in early Drosophila embryo
Authors: Li Yujun
Published: July 2024

The transcription activation of the zygotic genome is meaningful in the starting stage of development of embryos, it is regulated by a complicated network of protein-DNA interactions and protein-protein interactions including transcription factors and signaling pathways, that follows a time sequence precisely to result in patterned expression and cell fate determination. Zelda as a pioneering transcription factor, modifies expression by binding to highly conserved TAGteam sites. In the present study, we focus on the regulation specific to the gene slow as molasses(slam). The results from in situ hybridization and ChIP-seq assays support the vital influence of Zelda on the expression of slam, yet a TAGteam knockout in vitro mutagenesis experiment is proposed to validate and provide insights to the precise manner of the binding of Zelda. The paper provides analysis of the cis-regulatory event, while more investigations shall be done on the effect of the micro-three-dimensional dynamics of transcription that may result in PolII binding ChIP peaks that appear scattered contiguous crowd, or into the flanking region.