bluuebunny/crossref_metadata_2025 huggingface dataset:
Regra secundária de reconhecimento
Authors: Andréa Gianfranco , Francisco José , Gundim Wagner
Published: September 2023

O positivismo jurídico é predominantemente ensinado e aplicado há décadas por profissionais da área jurídica brasileira, geralmente com referência à construção teórica de Hans Kelsen (1881-1973), deixando à margem muitos outros estudos que oferecem importantes formulações e conceitos para a compreensão do Direito contemporâneo. Este artigo se junta a algumas poucas pesquisas sobre outros referenciais teóricos acerca do positivismo jurídico, analisando a regra de reconhecimento no pensamento teórico de Herbert Hart (1907-1992), apresentando-a como incremento e superação da teoria imperativista de John Austin (1790-1859). A partir de pesquisa bibliográfica, mostramos que, em Hart, a regra de reconhecimento (modalidade de regra secundária) apresenta-se indispensável para a certeza necessária ao Direito, bem como para aferir a validade do sistema jurídico.
PENEGAKAN HUKUM PIDANA PEMILU/PILKADA ELEKTRONIK PADA PEMILU/PILKADA SERENTAK 2024
Authors: Pirmansyah Redi , Junaidi Junaidi , Merta Martindo
Published: September 2023

ABSTRACTElection criminal provisions regulated in Law Number 7 of 2017 concerning General Elections only cover 80 articles of election crimes and do not comprehensively regulate election criminal acts in the electronic field for all applications to be used in the 2024 Election. This can create a legal vacuum or the obscurity of election crimes in the field of electronics in the use of electronic election systems. Although Law Number 19 of 2016 concerning Amendments to Law Number 11 of 2008 concerning Electronic Information and Transactions generally regulates electronic crimes, the 11 articles of electronic crimes do not regulate electronic crimes at the time of the election stage. The electronic election crime above will guarantee protection for all applications that will be implemented by the KPU in carrying out the 2024 election stages. In the context of this crime, the "electronic election system" includes all electronic systems used by the KPU in accordance with the Decree of the General Election Commission of the Republic of Indonesia Number 13/TIK.03/14/2022 concerning Plans for Electronic-Based Government Systems. This regulation will provide legal clarity for the prosecution of electronic election crimes in Indonesia  ABSTRAKKetentuan pidana pemilu yang diatur dalam Undang-Undang Nomor 7 Tahun 2017 tentang Pemilihan Umum hanya mencakup 80 pasal tindak pidana pemilu dan tidak secara menyeluruh mengatur tindak pidana pemilu di bidang elektronik untuk semua aplikasi yang akan digunakan dalam Pemilu 2024. Ini dapat menimbulkan kekosongan hukum atau ketidakjelasan pidana pemilu di bidang elektronik dalam penggunaan sistem elektronik pemilu. Meskipun Undang-Undang Nomor 19 Tahun 2016 tentang Perubahan atas Undang-Undang Nomor 11 Tahun 2008 tentang Informasi dan Transaksi Elektronik, secara umum mengatur tindak pidana elektronik, namun 11 pasal tindak pidana elektronik tersebut tidak mengatur pidana elektronik pada saat terjadinya tahapan pemilu. Kejahatan pemilu elektronik di atas akan menjamin perlindungan terhadap seluruh aplikasi yang akan diterapkan oleh KPU dalam melaksanakan tahapan pemilu 2024. Dalam konteks tindak pidana tersebut, "sistem elektronik pemilu" mencakup semua sistem elektronik yang digunakan oleh KPU sesuai dengan Keputusan Komisi Pemilihan Umum Republik Indonesia Nomor 13/TIK.03/14/2022 tentang Rencana Sistem Pemerintahan Berbasis Elektronik. Aturan ini akan memberikan kejelasan hukum bagi penindakan kejahatan pemilu elektronik di Indonesia
Ultrasound potential in sarcopenic obesity diagnosis: a literature review
Authors: Tsygankov D. A. , Krivoshapova K. E. , Tsygankova D. P.
Published: September 2023

With an increase in the average life expectancy of the population, the prevalence of sarcopenic obesity (SO) is correspondingly growing. Existing definitions of SO are based on description of sarcopenia and obesity, but there is currently no consensus defining thresholds for either of these conditions, making an accurate diagnosis difficult. At the same time, its treatment is important to prevent disability in the elderly. In this regard, the purpose of this review was to analyze the ultrasound potential for SO diagnosis. Since ultrasound is cheaper, more portable, and more accessible than other methods, it has the potential to be widely used as a clinical screening tool for identifying people with SO. Also, this method can be used to diagnose obesity, thereby leveling the errors in body mass index.
Position of the Russian Society of Cardiology experts on improving the cardiology education in medical schools in compliance with the educational continuity
Authors: Khasanov N. R. , Zagidullin N. Sh. , Shaposhnik I. I. , Zvereva T. N. , Grigoryeva N. Yu. , Tarlovskaya E. I.
Published: September 2023

on behalf of the Committees of the Russian Society of Cardiology for work with medical schools of the Russian Federation and for educational activities and youth policy

Cardiovascular diseases take a leading place in the morbidity pattern worldwide, and therefore improving the cardiology education in medical schools is very relevant. In addition, the rapid development of diagnostic and treatment methods poses very different challenges for students and teachers. In particular, at present, high-tech methods, such as radiofrequency ablation, molecular diagnostics, are practically not included in the standard curriculum. Also, differences in educational tracks in different universities often do not allow creating a single educational cardiology space. The article discusses the continuity of cardiology education at the university at different departments (study years), as well as theoretical, practical competencies of 3-6 study years at internal medicine departments, as well as electives and academic competitions in cardiology and the related problems.
Postoperative complications and predictors of mortality in surgery for left-sided infective endocarditis: a single-center retrospective study
Authors: Enginoev S. T. , Demetskaya V. V. , Kozmin D. Yu. , Pasyuga V. V. , Demin D. A. , Demina E. V. , Stompel D. R. , Chernov I. I.
Published: September 2023

Aim. To assess postoperative complications and predictors of mortality in surgery for left-sided infective endocarditis (IE).

Material and methods. The retrospective analysis included 222 cases of IE in 216 patients who were operated on from January 2015 to November 2022. Inclusion criteria: age of patients ≥18 years, definite or probable (Duke criteria) left-sided IE of aortic and/or mitral valves. There were following exclusion criteria: isolated right-sided IE (tricuspid valve, pacemaker endocarditis), nonbacterial thrombotic endocarditis and chronic IE. Endpoints: inhospital mortality, postoperative complications (delirium; perioperative stroke; resternotomy for bleeding; perioperative myocardial infarction; acute heart failure requiring extracorporeal membrane oxygenation or intra-aortic balloon pumping; respiratory failure requiring tracheostomy; acute kidney injury requiring renal replacement therapy; conduction disorder requiring pacemaker implantation).

Results. Median age was 53 [38,0; 61,0] years, while the majority of patients were men (73,9%). Inhospital mortality was 8,6%. The most common postoperative complications were delirium (19,8%) and bleeding requiring resternotomy (10,4%). The incidence of perioperative stroke was 2,3%, perioperative myocardial infarction - 0,9%, respiratory failure with tracheostomy – 4,5%, pacemaker implantation – 2,7%, renal replacement therapy – 6,8%. According to multivari ate analysis, Predictors of inhospital mortality were creatinine clearance level (odds ratio (OR), 0,976; 95% confidence interval (CI): 0,956-0,996; p=0,020), time of cardiopulmonary bypass (OR, 1,014; 95% CI: 1,006-1,021 , p<0,001), deli rium (OR, 7,058; 95% CI: 1,824-27,330, p=0,005) and acute kidney injury requiring renal replacement therapy (OR, 28,620; 95% CI: 6,508-125,964; p<0,001).

Conclusion. Surgical treatment of left-sided IE has satisfactory inho spital outcomes. The study identified simple clinical factors (creatinine clearance, cardiopulmonary bypass time, delirium, acute kidney injury) associated with inhospital mortality.
Chronic myocarditis as a cause of recurrent episodes of ventricular tachycardia and dilated cardiomyopathy requiring heart transplantation: a case report
Authors: Stavtseva Yu. V. , Teterina M. A. , Ubaydullaeva D. A. , Vorobyov A. S. , Meray I. , Kobalava Zh. D.
Published: September 2023

We present a clinical description of a patient with recurrent resistant episodes of ventricular tachycardia that first appeared at the myocarditis onset and remained the only disease manifestations for several years. During follow-up, the patient was diagnosed with dilated cardiomyopathy, which required heart transplantation.
Surgical treatment of aortic root abscess: 10-year single center experience
Authors: Enginoev S. T. , Zenkov A. A. , Magomedov G. M. , Abdulmejidova U. K. , Guliyev M. A. , Chernov I. I. , Gubareva E. Yu.
Published: September 2023

The issue of optimal surgical scope in patients with aortic root abscess due to infective endocarditis remains open, since there are different strategies and interventional methods. In addition, the guidelines do not give preference to any particular type of surgical intervention and recommend an individual approach to each situation. The study included 25 patients with aortic root abscess due to aortic valve infective endocarditis. The most frequently performed surgical intervention in patients was the Ross procedure (n=12, 48%). Eight (32%) patients of the center underwent aortic homograft root replacement. Combined surgery was performed in 7 (28%) patients as follows: 3 (12%) patients — interventions on the mitral valve (all patients underwent mitral valve repair due to mitral valve involvement in abscess), 3 (12%) — coronary artery bypass grafting, 1 (4%) — ascending aortic replacement due to dilatation. Five- and ten-year survival after surgical treatment of patients with aortic root abscess was 86,9% and 78,6%, respectively. There was no reintervention and recurrence of infective endocarditis in the long-term period.
Avaliação preliminar de uma série de casos prospectiva e randomizada comparando placa e parafusos x fixador externo circular de Ilizarov para fraturas do pilão tibial
Authors: Matias Victor Elzio Gasperoni , Brito Gustavo Venancio de , Spósito Aurélio Lazzaroni , Zamboni Caio , Mercadante Marcelo , Christian Ralph Walter
Published: September 2023

OBJETIVO: comparar duas abordagens cirúrgicas para fraturas do pilão tibial: redução aberta e fixação interna com placa e parafusos versus redução fechada e fixação externa com o fixador externo circular de Ilizarov, constituindo um estudo prospectivo randomizado e busca determinar quais pacientes se beneficiam mais com cada abordagem cirúrgica. MÉTODOS: A pesquisa envolveu 19 pacientes com fraturas do pilão tibial, divididos em dois grupos de acordo com seus respectivos números de prontuário e foram avaliados considerando a qualidade da redução articular, complicações agudas em relação a esses dois métodos e com lesões associadas e comorbidades por um seguimento ambulatorial mínimo de quatro meses. RESULTADOS: não houve diferença quanto a qualidade de redução, já em relação a complicações agudas e necessidade de reabordagens o grupo de pacientes submetido a redução aberta e fixação interna com placa e parafusos apresentou piores resultados. CONCLUSÃO: a escolha entre os métodos deve ser individualizada, considerando as lesões e comorbidades específicas de cada paciente.
m6A Writer METTL3-Mediated lncRNA LINC01125 Prevents the Malignancy of Papillary Thyroid Cancer
Authors: He Tianyou , Xia Hailiang , Chen Baojie , Duan Ziqi , Huang Chaogang
Published: September 2023

Background: Long non-coding RNA (lncRNA) LINC01125 is an anti-tumor factor in a variety of tumors, and regulates cancer cell function. However, its function and mechanism of N6-methyladenosine (m6A) modification in papillary thyroid cancer (PTC) tumorigenesis remain unclear.

Aims: This study aimed to reveal the function and m6A modification of LINC01125 in PTC tumorigenesis.

Methods: The LINC01125 and methyltransferase-like 3 (METTL3) levels in PTC cells and tissues was assessed by qRT-PCR. The binding relationship among LINC01125 and METTL3 was determined by MeRIP, Pearson, bioinformatics, and RNA stabilization analysis. Transwell assays were performed to confirm the changes of PTC cell migration and invasion. Cell proliferation was revealed by CCK-8 as well as colony formation assays.

Results: Low expression of LINC01125 and METTL3 was identified in PTC. LINC01125 was a downstream target of METTL3-mediated m6A modification and was stably upregulated via METTL3. Cell invasion, migration, viability, and colony formation levels were decreased when LINC01125 or METTL3 was upregulated. Inhibition of LINC01125 had the opposite impact, promoting cell proliferation and metastasis, and reversing METTL3 overexpression-resulted cell malignancy suppression.

Conclusions: Overall, this study proved that the m6A modification of LINC01125 was mediated by METTL3 and LINC01125 inhibited cell invasion, migration and proliferation, thereby suppressing the development of PTC. This points to the LINC01125-m6A-METTL3 axis as a possible prospective target for future treatment of PTC.
THE EFFICACY OF CT-GUIDED PERCUTANEOUS CORDOTOMY ON INTRACTABLE PAIN IN PATIENTS WITH LUNG CANCER
Authors: EGE Ferhat , AKBAS Mert , DAĞISTAN Gözde
Published: September 2023

ABSTRACT

Aim

This study was carried out to evaluate the efficacy of CT-guided percutaneous cordotomy and postoperative complications in the treatment of intractable pain associated with lung cancer.

Material &Method

Computed tomography (CT) guided-cordotomy was performed on 10 lung cancer patients unresponsive to medical and interventional pain management methods.

Results

The mean pretreatment and post treatment visual analogue scale (VAS) scores of the patients were determined as 10 ± 0.0001 and 1.00 ± 0.67, respectively. Additionally, the mean pretreatment and posttreatment Karnofsky Performance Scale (KPS) scores of the patients were calculated as 40± 9.42 and 73±10.59, respectively. Accordingly, there was a statistically significant difference between the pretreatment and posttreatment VAS and KPS scores. Furthermore, the mean pretreatment and posttreatment morphine equivalent dose of the patients were found as 860.2±199.8 mg and 220.7±69.08 mg, respectively.

Conclusion

The findings of this study suggest that cordotomy is a valuable treatment option for intractable pain problems in patients suffering from lung cancer.
Yaşa Bağlı Makula Dejenerasyonu İle Serum Anneksin A3 (ANXA3) Düzeylerinin İlişkisi
Authors: ÖZTÜRK Alpaslan , GÜL Mehmet Ali , AĞBEKTAŞ Tuğba , ZONTUL Cemile , ÇİFTÇİ Cem Hakan , TAŞ Ayça , YALINBAŞ YETER Duygu , SİLİĞ Yavuz
Published: September 2023

Giriş: Yaşa bağlı maküler dejenerasyonu gelişmiş toplumlarda ileri derecede görme kaybının en sık nedenidir. ANXA3, hücre sinyal yolakları, hücre profilerasyonu, invazyon, metastaz ve hücre apoptozuna etki ederek tümör gelişimine katkı sağlamaktadır.

Yöntemler: Bu çalışma yaş tip YBMD tanısı alan 39 hasta, aynı zaman diliminde kuru tip YBMD tanısı alan 39 olmak üzere toplam 78 hasta ve daha önce herhangi bir maküler dejenerasyon tanısı almamış sağlıklı 39 kontrol grubundan oluşturuldu. ANXA3 düzeyleri enzim bağlantılı immünosorbent tahlil (ELISA) yöntemi ile tespit edildi.

Bulgular: Bu çalışmada serum ANXA3 düzeyleri kontrol grubuna göre kuru tip YBMD hastalığında anlamlı bir farklılık tespit edildi (p
The Case for Neutrality: Understanding African Stanceson the Russia-Ukraine Conflict
Authors:   Leeds Beckett University, Ajala Olayinka
Published: September 2023

The war in Ukraine is impacting most countries in the world. Economically, prices of goods and services are rising and manycountries around the world are experiencing energy crises that can be linked to the war in Ukraine. Politically, fracturesare appearing in long-established political structures with many countries around the world deciding on how to respondto the war in Ukraine based on their political, economic, and strategic interests. Surprisingly, Africa is generating a lot ofattention due to the stance of several notable countries – including some seen as key allies of Western countries. Contraryto expectations that most African countries except those ruled by despots would follow the West in condemning and puttingpressure on Putin to end the war, many African countries chose to stay neutral without condemning Russia or supportingresolutions to put pressure on Putin to end the war. This article has explored not only the role of neo-imperialism in shiftingpolitical alliances away from the West as well as a key factor fostering neutrality, but also other factors. It has made use ofUN resolution voting patterns as well as statements made by African leaders as lenses through which the stances of Africanleaders can be understood. The article “The Case for Neutrality: Understanding African Stances on the Russia-Ukraine Conflict” by Olayinka Ajala is translated and published with permission of the author and и Journal of Military and Strategic Studies, where it was originally published in English (Journal of Military and Strategic Studies (2022), vol. 22, iss. 2). Available at: https://www.mapleleafnavy.com/index.php/2023/02/16/journal-of-military-andstrategic-studies-volume-22-issue-2/.
Mega FTAs and the Indo-Pacific Economic Framework (IPEF) in the Asia Pacific Region: Will It Be Cooperation or Competition?
Authors:   Tech University of Korea, Park Sang-Chul
Published: September 2023

The Regional Comprehensive Economic Partnership (RCEP) and the Comprehensive and Progressive Agreement for Trans-Pacific Partnership (CPTPP) are two mega free trade agreements (FTAs) in the Asia and Pacific region. However, theireconomic interests are rather deeply divided and related to political and security issues. Trade conflicts between the U.S.and China have continued since 2018. To tackle Chinese expansion, the Biden administration initiated the Indo-PacificEconomic Framework (IPEF) in 2021 instead of returning to the CPTPP. This article reviews the two mega FTAs and theIPEF, as well as East Asian collaboration and competition in the region. It examines the East Asian countries’ economicinterests in participating in the mega FTAs and the IPEF and considers how to overcome the protectionism caused by thetrade conflicts between G2. Finally, it analyzes the roles and strategies of major economies overcoming protectionism as thenew global supply and value chains are reshaping in the region.
noesypr1d_metab.nan v1
Authors: KB NAN
Published: September 2023

This is a protocol for running the Bruker pulse program "noesypr1d".
Parametric study on the performance of industrial byproducts based geopolymer concrete blended with rice husk ash & nano silica
Authors:   Department of Civil Engineering, Kalasalingam Academy of Research and Education, Maheswaran M. , Christy C. Freeda ,   Department of Civil Engineering, Kalasalingam Academy of Research and Education, Muthukannan M. ,   Department of Civil Engineering, KCG College of Technology, Arunkumar K. ,   Department of Civil Engineering, Mangalam College of Engineering, Vigneshkumar A. ,   Department of Civil Engineering, Kalasalingam Academy of Research and Education
Published: September 2023

In this study, Geopolymer concrete (GPC) blended with fly ash (FA), ground granulated blast furnace slag (GGBS), rice husk ash (RHA), and nano-silica (NS) developed and investigated in three aspects: In the first aspect of GPC (FA+GGBS), FA varied from 0-100% of GGBS at 10 % intervals to determine the optimum proportion of FA-GGBS. In the second aspect of GPC (FA+GGBS+RHA), RHA varied from 0-25% of FA at 5% intervals with a constant of 30% GGBS attained from the first aspect of the study. In the third aspect of GPC (FA+GGBS+RHA+NS), NS was replaced with 1, 3, and 5% with the optimum proportions of GGBS (30%) and RHA (15%) obtained from the first and second aspects of the study. The fresh and hardened properties of GPC were obtained at 7 and 28 days under ambient curing. The compressive strength improved while FA was replaced by GGBS (0-100%) from 27.75 to 45 MPa. Meanwhile, workability has decreased to 0.81 from 0.97. Hence, the optimized proportion of FA and GGBS was obtained as 70:30 from the workability aspect. RHA replacement provided compressive strength increment up to 15% (39.5 MPa), but workability gradually decreased (0.92 to 0.84) from 0 to 25%. So, the optimum proportion of RHA was achieved by 15% from the second aspect. In the third aspect, the workability increased from 0.89 to 0.92 while NS replacement (0-3%) with FA. Also, compressive strength has improved from 39.52 to 41.95 MPa. Thus, the optimized NS proportion gained at 3% of NS. Overall, this study provides a view of industrial by-product utilization as part of GPC in optimal proportions.
Minor histocompatibility antigens represented in HLA-A*02:01 and their search strategies
Authors: Romanyuk D. S. , Pilunov A. M. , Efimov G. A. , Bogolyubova A. V. , Parovichnikova E. N.
Published: September 2023

Minor histocompatibility antigens (MiHAs) are polymorphic peptides on the cell surface derived from self-proteins that are capable to induce an immune response during allogeneic hematopoietic stem cells transplantation. Their presentation occurs in the context of the certain major histocompatibility complex (HLA – human leucocyte antigen) alleles. One of the most common HLA alleles is HLA-A*02:01. Accordingly, for a significant number of donors and recipients pairs, it is possible to use the MiHAs presented in the HLA-A*02:01 as a target for relapsed leukemia therapy. This review discusses the main known MiHAs presented in the context of HLA-A*02:01, their characteristics and approaches used for identification. The described approaches may be used to search for new MiHAs for immunotherapy.
Toxicity of L-asparaginase drugs in acute lymphoblastic leukemia treatment
Authors: Valiev T. T.
Published: September 2023

Currently no therapy of acute lymphoblastic leukemia is conceivable without L-asparaginase drugs, with its antileukemic effect by extracellular asparagine depletion, thus preventing its admission to leukemic cell. Besides high antitumor effect, L-asparaginase drugs have side and toxic effects, such as hypersensitivity reactions, thrombosis, pancreatitis / pancreatic necrosis, and hepatotoxicity. For L-asparaginase safety profile improvement a technology of pegylation was lay down and PEG-aspargase drug produced. This drug has less toxic effects and recommended as first-line therapy of acute lymphoblastic leukemia. Drug monitoring for assessment the effectiveness and toxicity of L-asparaginase is optimal. Such therapy individualization helps for L-asparaginase dose finding and decrease frequency and severity of side effects.
An integrated treatment approach in patient with metastatic colorectal cancer and concomitant late cardiovascular complications of chemoradiotherapy for Hodgkin’s lymphoma. Clinical case
Authors: Ryabukhina Yu. E. , Zeynalova P. A. , Akhobekov A. A. , Chekini D. A. , Ibragimov E. K. , Cheishvili Z. M. , Kopaliani T. I. , Gruzdev V. E. , Zhukov A. G. , Valiev T. T.
Published: September 2023

The high efficacy of the currently used combined chemoradiotherapy for Hodgkin’s lymphoma not only significantly increased overall survival, but also made it possible for most patients to achieve the same quality of life as in a healthy population. at the same time, the problem of identifying late treatment complications, in particular cardiovascular the high efficacy of the currently used combined chemoradiotherapy for Hodgkin’s lymphoma not only significantly increased overall survival, but also made it possible for most patients to achieve the same quality of life as in a healthy population. at the same time, the problem of identifying late treatment complications, in particular cardiovascular diseases, remains an urgent problem, the timely diagnosis of which is an important task. the development of a second malignant neoplasm and the appointment of drug antitumor therapy with cardiotoxic agents necessitate a multidisciplinary approach. In the presented clinical observation, such tactics of patient management made it possible not only to timely identify late cardiovascular complications of Hodgkin’s lymphoma chemoradiotherapy, but also to conduct treatment for the second malignant disease with cardiotoxic agents with a positive antitumor effect.
Experience of 2nd line therapy with eltrombopag in patients with immune thrombocytopenia
Authors: Zakharov S. G. , Mitina T. A. , Vardanyan R. V. , Tekeeva Z. R. , Kontievskiy I. N. , Chuksina Yu. Yu. , Zakharova A. V.
Published: September 2023

Background. Immune thrombocytopenia (ITP), or idiopathic thrombocytopenic purpura, is a hematological autoimmune disease characterized by bleeding and an isolated decrease in platelet count <100 × 109 / l. The decision to start treatment for ITP depends on several factors. The ITP treatment strategy is based on the clinical symptoms, with a focus on reducing the risk of severe bleeding and increasing platelet counts.

   Aim. To evaluate the efficacy of 2nd line therapy with the thrombopoietin receptor agonist eltrombopag in patients with ITP.

   Materials and methods. 490 patients with ITP are under observation at the center for orphan diseases of M. F. Vladimirskiy Moscow Regional Research Clinical Institute. The present study included 186 patients with primary ITP after 1st line glucocorticosteroid therapy. eltrombopag, a thrombopoietin receptor agonist, was prescribed as the 2nd line of therapy.

   Results. The median platelet count prior to eltrombopag therapy in all patients was 27.5 × 109 / l. after eltrombopag therapy, a significant (by 490 %) increase in platelet levels (median 135 × 109 / l) and a complete response according to clinical recommendations were noted.

   Conclusion. Glucocorticosteroids (prednisolone, dexamethasone) remain the drugs of choice for the 1st line of therapy. Treatment with drugs of this group in most cases allows achieving an optimal platelet level and preventing bleeding. In case of inefficiency, intolerance, occurrence of side effects, the appointment of thrombopoietin receptor agonists eltrombopag or romiplostim is recommended. therapy with eltrombopag at a dose of 50 mg daily for several weeks has been able to achieve an increase in platelet levels, correct hemorrhagic syndrome, reduce the number of side effects during first-line glucocorticosteroid therapy, and improve the patient’s quality of life.
Clonal hematopoiesis and acute myeloid leukemia
Authors: Kashlakova A. I. , Biderman B. V. , Parovichnikova E. N.
Published: September 2023

During aging phenotypic changes in the hematopoietic system occur, and possible reason of these changes can be accumulation of gene mutations in hematopoietic stem cells or early blood progenitors. Although these mutations are mostly neutral, some may give hematopoietic stem cells and progenitor cells a proliferative advantage. In this case clonal hematopoiesis will arise, which is characterized by the formation of a genetically distinct subpopulation of blood cells. Clonal hematopoiesis may become a basis for the development of hematologic malignancies, such as acute myeloid leukemia. Clonal hematopoiesis associated genes which are most commonly mutated in acute myeloid leukemia patients are DNMT3A, TET2 and ASXL1. The prognostic significance of these gene mutations currently remains a subject of study.
Location of inception point of alternating steps stepped spillways
Authors:   University of Sulaimani, College of Engineering, Department of Water Resources Engineering, Muhammed Burhan , Abdulrahman Kawa ,   University of Sulaimani, College of Engineering, Department of Water Resources Engineering
Published: September 2023

This study explored the effects of flat-stepped spillways having alternating steps on the inception point location. Two wooden stepped spillways with a longitudinal slope of 26.6° were constructed in a rectangular flume and tested at various discharges, ranging from 0.003 to 0.05 m3/s. Each model had twenty-seven steps, and the channel's width, depth, and length were 0.605 meters, 1.35 meters, and 8 meters. The outcomes showed that the Alternating Model (MA), compared to the Regular Model (MR), has shortened the inception point distance (Li) from the downstream crest of the spillway by an average of 27% (e.g., the Li of the MR model was 59 cm, and the Li of the MA model was 43 cm). The MA model's skimming flow was discovered to begin at higher discharges, at yc/h 1.24 (as opposed to yc/h=0.98 for the MR model). Two equations were also developed to compute the inception point positions for flows over the MA and MR stepped spillways.
Big Data Guided Unconventional Digital Reservoir Energy Ecosystem and its Knowledge Management
Authors:   Curtin University, Nimmagadda Shastri , Mani Neel ,   Amity University, Reiners Torsten ,   Curtin University, Wood Lincoln C. ,   Otago University
Published: September 2023

Abstract Background: In shale basins, petroleum systems are complex; they hold data sources in Big Data scales. The motivation of research lies with the facts of exploring effective inherent connectivity between unconventional petroleum systems. The connectivity between energy reservoir systems is ambiguous within a distinctive petroleum ecosystem. Heterogeneity and multidimensionality of unstructured data sources are additional challenges, precluding systematic modelling of diverse petroleum systems and their data integration process, including growing demand for storage systems. The research aims to establish the knowledge-based connectivity between petroleum systems through Information System (IS) articulations, visual analytics and data management. Method: We investigate the knowledge-based IS guided exploration and production systems to explore the connectivity between diverse unconventional petroleum systems and forecast the reservoir energy. We articulate Design Science Information System (DSIS), bring various IS artefacts, unify multiple domains of petroleum provinces and analyze the associativity between petroleum systems. In addition, use, reuse, effectiveness and interoperability are utility properties of IS artefacts that we evaluate. We implement IS solutions in the oil and gas industries to facilitate database management and reservoir energy exploration. Results: We simulate DSIS as an Unconventional Digital Petroleum Ecosystem (UDPE) as it allows us to investigate and ascertain the interplay between petroleum systems’ elements and processes. Metadata cubes are computed for data views to visualize, interpret, and implement IS articulations in energy systems. We compute the structure and reservoir attribute views for interpreting energy-driven petroleum systems, prospect evaluation and business-knowledge management with a viable DSIS solution. Conclusions: The DSIS emerges as a knowledge-based digital ecosystem innovation, demonstrating how it can effectively interconnect geographically controlled petroleum systems. Its development, in the exploration of unconventional shale basins, is a knowledge-based reservoir-energy management solution. This research is beneficial to IS practitioners who wish to pursue energy research in reservoir ecosystem contexts.
A Review of Research Methodologies Employed in Serendipity Studies in the Context of Information Research
Authors:   Faculty of Science and Engineering, University of Nottingham, Sun Xu , Zhou Xiaosong ,   School of Mechanical and Electrical Engineering, Guizhou Normal University, Wang Qingfeng ,   University of Nottingham Business School Ningbo China, University of Nottingham, Sharples Sarah ,   Human Factors Group, University of Nottingham, Zhang Yaorun ,   Faculty of Science and Engineering, University of Nottingham
Published: September 2023

Abstract Background: The concept of serendipity has become increasingly interesting for those undertaking serendipity research in recent years. However, serendipitous encounters are subjective and rare in a real-world context, making this an extremely challenging subject to study. Methods: Various methods have been proposed to enable researchers to understand and measure serendipity, but there is no broad consensus on which methods to use in different experimental settings. A comprehensive literature review was first conducted, which summarizes the research methods being employed to study serendipity. It was followed by a series of interviews with experts that specified the relative strengths and weaknesses of each method identified in the literature review, in addition to the challenges usually confronted in serendipity research. Results: The findings suggest using mixed research methods to produce a more complete picture of serendipity and contribute to the verification of any research findings. Several challenges and implications relating to empirical studies in the investigation of serendipity have been derived from this study. Conclusions: This paper investigated research methods employed to study serendipity by synthesizing finding from a literature review and the interviews with experts. It provides a methodological contribution to serendipity studies by systematically summarizing the methods employed in the studies of serendipity and identifying the strengths and weakness of each method. It also suggests the novel approach of using mixed research methods to study serendipity. This study has potential limitations related to a small number of experts involved in the expert interview. However, it should be noted that the nature of the topic is a relatively focused area, and it was observed after interviewing the experts that new data seems to not contribute to the findings owing to its repetition of comments
Mobile Healthcare Design Research: A Special Issue for Information Systems Researchers
Authors:   University of Newcastle, Miah Shah J. , Burmeister Oliver K. ,   Charles Sturt University, Australia
Published: September 2023

Abstract Special Section Editorial - Mobile Decision Support and Analytics for Healthcare: Citizen, Organization, Governmental and Technological Perspectives
Transition from Offline to Online through Digital Resource Bricolage in A Health Crisis: A Case Study of Two Primary Schools
Authors:   Dalian University of Technology, Cui Miao , Qian Jinfang ,   Dalian University of Technology, Dai Xin ,   Huazhong University of Science and Technology, Liu Mengjun ,   Hubei University
Published: September 2023

Abstract Background: Health crisis responses underline maintaining normal operations. By utilizing digital resources, organizations are able to maintain essential operations through transiting their operations from offline to online during a health crisis. However, little is known about how organizations rapidly adapt to online operations. By taking resource bricolage as the theoretical lens, this study investigates the process that organizations rapidly transit from offline to online through digital resource bricolage during health crises. Methods: A case study of two primary schools that maintained operations during COVID-19 was conducted, with a focus on the utilization of digital resources and resource bricolage. Secondary data collection, interviews and coding strategy were utilized to collect and analyze data to reveal the process that organizations rapidly transit from offline to online through digital resource bricolage. Results: The findings reveal a sequential three-step resource bricolage process, including redeploying digital resource functions, combining digital and non-digital resources, and coordinating interaction among participants, as well as the corresponding resource bricolage behaviors and domains. Conclusions: This study contributes to information systems (IS) studies on crisis responses by identifying the sequential steps of digital resource bricolage to transit from offline to online during health crises. In addition, this study contributes to the development of resource bricolage perspectives by identifying new resource bricolage actions that suitable for the health crisis response.
GÜZEL SANATLAR EĞİTİMİNDE UYGULAMALI ATÖLYE DERSLERİNİN UZAKTAN EĞİTİMİNE YÖNELİK ÖĞRENCİ GÖRÜŞLERİ
Authors: Özpolat Kainat
Published: September 2023

Bu araştırma dünyanın yaşadığı salgın ve Türkiye’de yaşanan depremlerde eğitim ve öğretimin çevrim içi yapılmasından dolayı, güzel sanatlar eğitiminde uygulamalı atölye derslerinin uzaktan eğitimine yönelik öğrenci görüşlerinden oluşmaktadır. Güzel sanatlar eğitimi atölye dersleri doğası gereği fiziki bir alana ihtiyaç duymaktadır. Aynı zamanda bir öğretici nezaretinde yapılması sanat eğitiminin gelişiminde olumlu etkilerle sonuçlanmaktadır. Araştırma bu bağlamda güzel sanatlar eğitiminde atölye dersini alan öğrenciler üzerine yönelmiştir. Güzel sanatlar eğitimi kategorisine ait öğrencilerin bu duruma yönelik görüşleri yarı yapılandırılmış görüşme formlarıyla toplanmıştır. Toplanan verilerde sanat eğitimi alan öğrenciler atölye derslerinin önemini kabul etmiş ve yeteneklerini artırmayı arzulamışlardır. Sanat eğitimi atölye dersi alan 21 öğrenci ile görüşmeler gerçekleştirilmiştir. Bu görüşmelerde, öğrencilerin atölye derslerinde ihtiyaç duydukları durumlar ve çevrim içi eğitimin avantajları ve dezavantajları bakımından görüşler bildirmişlerdir. Sanat eğitimi atölye dersi alan öğrenciler ile yapılan görüşme formlarının analiz edilmesi ile 5 kategoriye ulaşılmıştır. Kategoriler; öğrencilerin atölye derslerinin uzaktan ya da yüz yüze olması gerektiğine yönelik düşüncelerini göstermektedir. Bu kategoriler; avantajlar, dezavantajlar, fiziki ortam, yüz yüze eğitim ve sanatsal gelişime olumlu ya da olumsuz katkılar başlıklarından oluşmaktadır. Araştırmaya katılan görüşleri alınan öğrencilere K1, K2. K3… kodu verilmiştir. Araştırmanın bulgular bölümünde kategoriler başlıklar halinde incelenecek ve öğrenci görüşleri verilirken de Katılımcının kısaltması olarak K kullanılacaktır.
Combination of Mucocele of the Appendix and Chronic Calculous Cholecystitis: Case Report
Authors: Akhtanin Evgeny A. , Goev Aleksander  A. , Shukurov Komildzhon  U. , Markov Pavel  V.
Published: September 2023

Background: The analysis of the data presented in the foreign and national literature shows that a combination of the appendix mucocele and calculous cholecystitis is extremely rare, and the implementation of simultaneous surgical treatment in the laparoscopic version is the optimal approach. Clinical case description. Here, we present a clinical case of chronic calculous cholecystitis in combination with mucocele of the appendix in an 84-year-old patient. The main complaint was pulling pain in the right iliac region. The diagnosis was made on the basis of the main and additional methods of examination: clinical picture, ultrasound, multispiral computed tomography and magnetic resonance imaging of the abdominal organs. In a planned manner, a simultaneous surgical intervention was performed consisting of laparoscopic appendectomy and cholecystectomy. The operation duration was 1 hour 15 minutes. The morphological examination confirmed the diagnosis of calculous cholecystitis and mucocele of the appendix. The patient was discharged in a satisfactory condition on the 4th day. Conclusion. This clinical case shows that the dynamic observation of mucocele of the appendix, even in elderly patients with a comorbid pathology, is unjustified. A simultaneous surgical intervention in the form of laparoscopic appendectomy and cholecystectomy treats the two nosologies and prevents repeated hospitalization and surgery.
Sifat fungsional choux pastry kering dengan substitusi konsentrat protein ikan gabus
Authors: Arsil Yuliana , Asih Esthy Rahman
Published: September 2023

Choux pastry kering dengan substitusi konsentrat protein ikan (KPI) gabus adalah produk pangan olahan yang mengandung protein yang cukup tinggi. Produk pangan olahan harus memiliki nilai gizi dan sifat fungsional yang baik. Tujuan penelitian ini untuk menentukan sifat fungsional choux pastry kering substitusi KPI gabus melalui parameter kekerasan, komposisi asam amino, dan daya cerna protein secara in vitro. Penelitian ini merupakan penelitian eksperimen dengan analisis laboratorium yang terdiri dari dua kelompok perlakuan yaitu kontrol dan choux pastry kering substitusi KPI gabus 15%. Uji kekerasan diukur dengan LLYOD texture analyzer. Komposisi asam amino diukur dengan metode UPLC, sistina dan metionina secara LC-MS/MS dan triptofan secara HPLC. Uji daya cerna protein secara in vitro dengan teknik enzimatis. Hasil penelitian menunjukkan nilai kekerasan choux pastry kering substitusi 15% KPI gabus lebih tinggi (35,42 N) dari kontrol (24,48 N). Kandungan asam amino choux pastry kering substitusi 15% KPI gabus lebih tinggi dari kontrol, dengan asam amino esensial tertinggi yaitu leusina (1,65%) dan lisina (1,30%), dan asam amino nonesensial tertinggi yaitu asam glutamat (4,23%) dan asam aspartat (1,87%). Nilai skor kimia, skor asam amino, dan indeks asam amino esensial choux pastry kering substitusi 15% KPI gabus lebih tinggi (12,98; 17,58; 16,83) dibandingkan kontrol (9,55; 14,10; 11,93). Daya cerna protein in vitro choux pastry kering substitusi 15% KPI gabus lebih rendah (38,22%) dibandingkan kontrol (47,96%).
Keamanan krim anti jerawat berbasis kitosan cangkang kerang bulu
Authors: Purwanto Ukhradiya Magharaniq Safira , Vachyra Dara Anggun , Andrianto Dimas
Published: September 2023

Kitosan merupakan senyawa hasil modifikasi kitin yang memiliki sifat antimikroba. Pembuatan krim berbasis kitosan sebagai sediaan kosmetik terutama untuk mencegah jerawat dinilai memiliki potensi yang cukup baik. Penelitian ini bertujuan untuk menentukan keamanan krim anti jerawat dengan penambahan kitosan cangkang kerang bulu (Anadara antiquata Linn.) dari cemaran logam berat dan mikroba. Pengujian cemaran logam berat dilakukan terhadap cangkang kerang bulu dengan Atomic Absorption Spectrophotometry (AAS). Pengujian cemaran mikroba yang dilakukan terdiri dari angka lempeng total (ALT) dan angka kapang khamir (AKK) dengan metode cawan tuang. Kadar timbel dan merkuri cangkang kerang bulu telah memenuhi standar dengan nilai berturut-turut sebesar 1,78 mg/kg dan <0,004 mg/kg. Nilai ALT untuk basis krim dan krim 5% juga sudah memenuhi standar dengan nilai berturut-turut 8,3x102 cfu/mL dan 7,2x104 cfu/mL, sedangkan nilai AKK belum memenuhi standar dengan nilai berturut-turut 2,2x104 cfu/mL dan 1,4x104 cfu/mL. Krim dengan penambahan kitosan 5% menunjukkan nilai ALT dan AKK yang lebih rendah dibandingkan basis krim (kontrol). Sediaan krim dengan penambahan kitosan belum memenuhi standar keamanan BPOM Indonesia untuk nilai AKK.
Pengaruh penambahan tepung ikan teri hitam (Stolephorus insularis) terhadap karakteristik kimia dan tekstur pizza base
Authors: Istifada Dina Shofa , Swastawati Fronthea , Wijayanti Ima
Published: September 2023

Ikan teri memiliki kandungan protein dan kalsium yang tinggi sehingga dapat difortifikasikan pada pizza base. Fortifikasi tepung ikan teri pada pizza base menjadi alternatif peningkatan konsumsi ikan pada masyarakat melalui diversifikasi produk. Penelitian ini bertujuan untuk menentukan konsentrasi terbaik pizza base dengan penambahan tepung ikan teri berdasarkan karakteristik fisik, kimia, dan sensori. Perlakuan pada penelitian ini adalah penambahan tepung ikan teri dengan konsentrasi 0, 4, 6, dan 8% pada pizza base. Parameter yang diuji meliputi protein, lemak, karbohidrat, abu, air, kalsium, cohesiveness, dan hedonik. Penelitian ini menggunakan model rancangan acak lengkap dan pengolahan data statistik menggunakan SPSS 25. Data parametrik dianalisis menggunakan uji sidik ragam (ANOVA) dan beda nyata jujur (BNJ), sedangkan data nonparametrik dianalisis menggunakan uji Kruskal Wallis. Hasil penelitian pizza base dengan penambahan tepung ikan teri memberikan pengaruh yang berbeda nyata (p<0,05) terhadap peningkatan protein, lemak, abu, dan kalsium serta penurunan karbohidrat, air, cohesiveness, dan hedonik. Konsentrasi 8% memiliki nilai nutrisi yang lebih baik, namun pizza base dengan konsentrasi tepung ikan teri 4% paling disukai panelis sehingga menjadi konsentrasi terbaik. Hasil uji hedonik pizza base dengan penambahan tepung ikan teri konsentrasi 4% memiliki nilai rata-rata 8,39±0,54 berdasarkan parameter warna, rasa, tekstur, dan aroma. Kandungan nutrisi pizza base dengan penambahan 4% ikan teri yaitu protein 17,39±0,44%, lemak 5,15±0,03%, karbohidrat 75,73±0,41%, abu 1,73±0,02%, air 7,42±0,69%, cohesiveness 0,71±0,02, dan kalsium 239,87±0,76 mg/100 g. Penambahan tepung ikan teri berpotensi meningkatkan nutrisi pizza base dengan tetap dapat diterima secara sensori.
Identifikasi kandungan ikan tenggiri (Scomberomorus commerson) dan ikan sapu-sapu (Pterygoplichthys sp) pada otak-otak
Authors: Suseno Dedy , Razari Intan
Published: September 2023

Ikan tenggiri merupakan jenis ikan yang umumnya digunakan dalam pembuatan otak-otak. Autentikasi produk pangan berbahan dasar ikan sulit dilakukan jika dilihat dengan mata telanjang sehingga adanya pemalsuan atau mislabeling pada produk tersebut sangat mungkin terjadi. Daging ikan sapu-sapu juga dapat digunakan sebagai bahan baku produk berbahan dasar ikan karena memiliki kandungan protein yang tinggi. Namun sumber ikan sapu-sapu yang diambil dari Sungai Ciliwung berpotensi mengandung logam berat di antaranya Pb, Cd, Hg, Sn, dan As. Tujuan penelitian yaitu mengidentifikasi kandungan ikan tenggiri dan ikan sapu-sapu pada produk otak-otak, dan identifikasi kandungan logam berat pada sampel otak-otak yang mengandung ikan sapu-sapu. Sampel otak-otak yang dianalisis sebanyak 19 dengan tiga sampel menuliskan keterangan ikan tenggiri pada kemasannya. Analisis DNA ikan sapu-sapu dan tenggiri pada otak-otak menggunakan metode Polymerase Chain Reaction (PCR) yang menggunakan primer spesifik. Analisis logam berat menggunakan metode Atomic Absorption Spectrophotometry (AAS). Hasil penelitian menunjukkan bahwa sebanyak 12 sampel teridentifikasi adanya pita berukuran 423 pb pada gel elektroforesis. Pita tersebut terkonfirmasi spesies ikan sapu-sapu (Pterygoplichthys sp.). Pita berukuran 238 pb juga ditemukan pada 9 sampel yang sesuai dengan produk PCR menggunakan primer ikan tenggiri (Scomberomorus commerson). Total 12 sampel otak-otak teridentifikasi mengandung ikan sapu-sapu, 11 di antaranya mengandung logam Pb dengan konsentrasi <0,034 mg/kg dan 1 sampel mengandung logam Pb dengan konsentrasi 0,34 mg/kg. Adanya kandungan logam berat pada sampel otak-otak yang konsentrasinya melebihi ambang batas maksimum menjadikan otak-otak tersebut tidak halalan thayyiban untuk dikonsumsi.