bluuebunny/crossref_metadata_2025 huggingface dataset:
The Source of the Legislative Professionalism Advantage: Attracting More Knowledgeable Candidates
Authors: Nemerever Zoe , Butler Daniel
Published: June 2020

Legislators who know their constituents' opinions are more likely to be successful in providing substantive representation on issues of the day. However, previous work suggests that state legislators and candidates commonly misestimate their constituents' preferences. Some of that work also finds that candidates and current incumbents in highly professionalized legislatures are less likely to misestimate constituent opinion. We investigate why this professionalism advantage exists. We use a Blinder–Oaxaca decomposition to determine how much of the professionalism advantage can be attributed to three sources: attracting knowledgeable candidates, fostering legislator knowledge in office, and retaining incumbents. We apply the decomposition to data on candidates' perceptions of public opinion from the 2014 National Candidate Survey. Fostering knowledge in office and retaining incumbents are not responsible for the professionalism advantage. We find evidence that the professionalism advantage occurs because higher professionalism legislatures attract more knowledgeable nonincumbent candidates.
Research on nonlinear modeling and dynamic characteristics of lateral stiffness of vehicle air spring system
Authors: Xu Liufeng
Published: June 2020

This paper established a lateral stiffness coupling model to investigate the lateral characteristics of air spring system under crosswind conditions. The nonlinear super-elastic characteristics, coupling characteristics of the air spring, lateral stiffness characteristics of emergency spring, and damping force are studied. The accuracy of the lateral stiffness model is validated by comparing with experimental data. In addition, the impact of geometric parameters on the lateral stiffness characteristics is discussed by a sensitivity analysis method, as well as the effect of the lateral stiffness model on vehicle mechanical performance is analyzed. The conclusions show that the lateral stiffness model can well predict the lateral characteristics of the air spring system, and provide theoretical guidance for the parameter design of rail vehicles and vehicle ride comfort improvement.
COVID-19: Africa’s relation with epidemics and some imperative ethics considerations of the moment
Authors: Tangwa Godfrey B. , Munung Nchangwi Syntia
Published: June 2020

COVID-19 is a very complex pandemic. It has affected individuals, different countries and regions of the world equally in some senses and differently in other senses. While sub-Saharan Africa has weathered a range of outbreaks of emerging and re-emerging infectious diseases, the manner in which the COVID-19 pandemic has evolved necessitates some observations, remarks and conclusions from our own situated observation point. Compared to previous epidemics/pandemics, many African countries have displayed a sense of solidarity in the face of COVID-19 that convincingly demonstrates that an Ubuntu ethic is viable and globalizable. The African continent seems, at last, to have realized that ethics dumping must be avoided and has made strides in defining its COVID-19 research agenda and strengthening its epidemic response for both public health and health research. More needs to be done in terms of public engagement, funding and technical support for research on potential therapies/candidate vaccines that are a product of scientific studies on the continent.
OXY-SCORE: a new perspective for left ventricular hypertrophy diagnosis
Authors: Quintana-Villamandos Begoña , Pazó-Sayós Laia , González del Pozo Irene , Rodríguez-Rodríguez Pilar , Bellón Jose María , Pedraz-Prieto Álvaro , Pinto Ángel G , González Maria Carmen
Published: June 2020

Background:

A recently developed global indicator of oxidative stress (OXY-SCORE), by combining individual plasma biomarkers of oxidative damage and antioxidant capacity, has been validated in several pathologies, but not in left ventricular hypertrophy (LVH). The aim of this study was to design and calculate a plasma oxidative stress global index for patients with LVH.

Methods:

A total of 70 consecutive adult patients were recruited in our institution and assigned to one of the two study groups (control group/LVH group) by an echocardiography study. We evaluated plasmatic biomarkers of oxidative damage (malondialdehyde and thiolated proteins) and antioxidant defense (total thiols, reduced glutathione, total antioxidant capacity, catalase, and superoxide dismutase activities) by spectrophotometry/fluorimetry in order to calculate a plasma oxidative stress global index (OXY-SCORE) in relation to LVH.

Results:

The OXY-SCORE exhibited a highly significant difference between the groups ( p < 0.001). The area under the receiver operating characteristic curve was 0.74 (95% confidence interval (CI), 0.62–0.85; p < 0.001). At a cut-off value of −1, the 68.6% sensitivity and 68.6% specificity values suggest that OXY-SCORE could be used to screen for LVH. A multivariable logistic regression model showed a positive association ( p = 0.001) between OXY-SCORE and LVH [odds ratio = 0.55 (95% CI, 0.39–0.79)], independent of gender, age, smoking, glucose, systolic and diastolic arterial pressure, dyslipidemia, estimated glomerular filtration rate, body mass index, and valvular/coronary disease.

Conclusion:

OXY-SCORE could help in the diagnosis of LVH and could be used to monitor treatment response.
Suboptimal glycemic control among subjects with diabetes mellitus in India: a subset analysis of cross-sectional wave-7 (2016) data from the International Diabetes Management Practices Study (IDMPS)
Authors: Ramachandran Ambady , Jain Sunil M. , Mukherjee Sagarika , Phatak Sanjeev , Pitale Shailesh , Singh Shailendra K. , Agrawal Navneet , Majumdar Anirban , Deshpande Neeta , Jhulka Sandeep , Minakshisundaram Shunmugavelu , Chawla Manoj , Lodha Sailesh , Maheshwari Anuj , Makkar Brij Mohan , Rao Sadashiva , Shah Parag , Ghosh Romik , Mohanasundaram Senthilnathan , Menon Shalini , Chodankar Deepa , Kanade Vaishali , Trivedi Chirag
Published: June 2020

Objective:

To assess the real-world management practices of subjects with type 2 diabetes mellitus (T2DM) and type 1 diabetes mellitus (T1DM) in India.

Methods:

This cross-sectional study was conducted between 7 March 2016 and 15 May 2016 in India as part of the seventh wave (2016) of the International Diabetes Management Practices Study (IDMPS). Adult subjects with T1DM or T2DM visiting physicians during a 2-week recruitment period were included.

Results:

A total of 55 physicians included 539 subjects who met eligibility criteria. Of 495 subjects with T2DM, 303 were treated with oral glucose lowering drugs (OGLDs) only, 158 were treated with OGLD + insulin, and 27 received insulin only. Among 44 subjects with T1DM receiving insulin, 13 (29.5%) were also treated with OGLD therapy. The most commonly used insulin regimens were basal alone (69/184; 37.5%) and premixed alone (63/184; 34.2%) in subjects with T2DM, and basal + prandial insulin (24/44; 54.5%) in subjects with T1DM. Proportions of subjects achieving glycemic targets were low [glycated haemoglobin (HbA1c) <7%: T1DM = 7.3% (3/44), T2DM = 25.2% (106/495); as targeted by the treating physician: T1DM = 31.8% (14/44), T2DM = 32.1% (59/185); global target: T1DM = 4.8% (2/42) and T2DM = 1.7% (8/482)]. In subjects with T2DM, HbA1c <7% was noted in 11/22 subjects receiving insulin only and 76/260 receiving only OGLDs. Lack of experience in self-managing insulin dosing, poor diabetes education and failure to titrate insulin dosages were the main reasons for non-achievement of glycemic targets.

Conclusion:

Timely insulinization, education and empowerment of people with diabetes may help improve glycemic control in India.
Subcutaneous nodules in children: Don’t forget deep granuloma annulare: A Case Report
Authors: Ran Cai Zhuo , Mamet Françoise , Kokta Viktor , Coulombe Jérôme
Published: June 2020

Deep granuloma annulare is an uncommon benign granulomatous skin disorder that presents almost exclusively in the paediatric population. It presents as an asymptomatic subcutaneous nodule with normal overlying skin on distal extremities, the scalp, or the forehead. It shows a deep palisading granuloma with areas of central necrobiosis on histologic examination. Due to its self-limited nature, clinical follow-up is recommended over surgical interventions. We present a case of cephalic deep granuloma annulare in a healthy 5-year-old girl who remains free of recurrence after surgical excision at the 6-month follow-up. Our case emphasizes the importance of differentiating the lesion from its clinical and histopathological mimickers, such as the rheumatoid nodule. The awareness of this entity is important to avoid the overinvestigation and overtreatment of a benign and self-limited disease.
Romantic Relationship Quality and Suicidal Ideation in Young Adulthood
Authors: Still Darla
Published: June 2020

Sociological research on suicidal ideation has often focused on structural factors, such as marital status, when analyzing the protective effects of social integration; however, less is known about how the quality of romantic relationships shapes suicidality among young adults. This study uses the National Longitudinal Study of Adolescent to Adult Health to examine the association between romantic relationship quality and suicidal ideation in young adulthood. Results indicate that simply being in a romantic relationship is unrelated to suicidal ideation. In fact, odds of reporting suicidal ideation are comparable for respondents who are married or cohabiting and respondents who are single or dating. Findings show that respondents who report greater romantic relationship quality in any romantic relation type are less likely to report suicidal ideation. This study contributes to previous research in the sociology of mental health by extending our understanding of the protective role of relationship quality.
Can Your Students Save the World? Utilizing Pandemic®, a Cooperative Board Game, to Teach Management
Authors: van Esch Chantal , Wiggen Todd
Published: June 2020

This article focuses on using the cooperative board game Pandemic® to teach management. In Pandemic, players must work together to cure four diseases and save the world. In this article, we suggest how it can be used in the classroom to teach decision making and also give guidance on how the game can help students learn how to reflect and put into practice the leadership, teamwork, goal setting, and ethical theories presented during management, leadership, and organizational behavior courses. Pandemic is a useful experiential teaching tool that engages students in complex decisions.
Educational Strategies to Develop and Implement a Comprehensive Health Care Model Focused on Primary Care in Colombia
Authors: Quintero Gustavo-Adolfo , Vergel John , Laverde Ángelo , Ortíz Luis-Carlos
Published: June 2020

The traditional, subject-based medical curriculum in Colombia has been mainly focused on the biomedical model proposed by Flexner in 1910. This means learning outcomes or competences are framed on curative care and the specialization of physicians. Students are mainly trained to work in highly complex hospitals in urban centers and encouraged to enroll (as soon as possible) in residencies. This curriculum lacks pertinence to implement the new Colombian Primary Health Care Model as the focus is a shift toward the promotion of health and prevention of illness. Recommendations to provide light on how to implement a change for ensuring pertinence of medical education in this context are discussed.
Development of a Hybrid, Interprofessional, Interactive Quality Improvement Curriculum as a Model for Continuing Professional Development
Authors: Kusters Isabelle S , Gregory Megan E , Bryan Jennifer L , Hysong Sylvia J , Woodard LeChauncy D , Naik Aanand D , Godwin Kyler M
Published: June 2020

Over the past 20 years, there has been an increased focus on quality improvement (QI) in health care, which is critical in achieving care that is patient-centered, safer, timelier, and more effective, efficient, and equitable. At the center of this movement is QI education, which is known to lead to learning, behavior change, and improved outcomes. However, there is a need for the development and provision of long-duration, interactive, interprofessional training in QI, to allow for in-depth learning and application of learned skills. To this end, we designed a curriculum for an established interprofessional, interactive, web-based QI fellowship for doctorally prepared clinicians. Curricular content is delivered virtually to geographically dispersed learners over a 2-year time span. The didactic curriculum and experiential learning opportunities provide learners with the foundational knowledge and practical skills to engage in—and eventually, lead—QI initiatives around the country. Evaluation of learner satisfaction and cognitive, affective, and skills-based learning has found that this model is an effective method to train geographically distributed learners. A hybrid training structure is used, where learners interact with the material through 3 distinct delivery modes: (1) virtual instruction in QI topics; (2) face-to-face training, mentorship, and the opportunity for practical application of applied knowledge and skills through the completion of QI projects; and (3) opportunities for other types of training, tailored to each learner’s Individual Development Plan. This training program model holds value for QI learning in various health care settings, which are interprofessional by nature. These foundational concepts of hybrid learning to distributed learners—wherein an instructor delivers curriculum in small, face-to-face batches, interprofessional learning is supplemented in a virtual, longitudinal manner, and learners are allowed the opportunity to put skills into action for real-world problems in interdisciplinary clinical teams—can be applied in a multitude of settings, with comparatively lower time and cost expenditure than traditional training programs.
Outcomes and comparison of nasolacrimal probing for patients older than 12 months
Authors: Zor Kürsad Ramazan , Küçük Erkut , Yılmaz Öztorun Zeynep
Published: June 2020

Objective:

In this study, we report the results of probing done in our clinic. We also want investigate role of late probing on outcome, especially in children older than 24 and 48 months.

Methods:

We retrospectively evaluated records of patients who underwent probing under general anaesthesia due to congenital nasolacrimal duct obstruction between 2013 and 2017 in Nigde Ömer Halisdemir University Faculty of Medicine in Nigde, Turkey. Success rates of probing for different age groups were compared.

Results:

143 eyes of 123 patients were included in the study. Overall success rate was 93.7% (134 eyes out of 143). We found the success rate as 95.5 in 12–18 months age group, 93.3% in 18–24 months age group, 93.8% in the 24–48 months age group, 86.6% in the 48 months and older age group. Overall success rate in 24 months and older age group was 91.5%. The second operation was performed on seven of the nine patients where the initial surgery failed, and successful results were achieved in six patients. Success rate was 100% after the second surgery in patients older than 48 months.

Conclusion:

The success rate of probing is high in patients with congenital nasolacrimal duct obstruction from 12 to 84 months. In patients with congenital nasolacrimal duct obstruction who are older than 48 months probing is effective and should be first-choice in this age group in management of congenital nasolacrimal duct obstruction. Probing may be used even in older patients who had previous unsuccessful probing.
Comparative Stability of Compounded Omeprazole Suspension Versus Commercial Omeprazole Kit When Stored in Oral Syringes Under Refrigerated Conditions
Authors: Jackson Remonica , Lewis Paul , Brown Stacy D.
Published: June 2020

Background: Omeprazole is a proton pump inhibitor used to manage gastrointestinal disorders. Special populations may require omeprazole to be given as an oral suspension. Objective: The purpose of this project was to compare the stability of omeprazole in the FIRST kit product to a traditionally compounded omeprazole suspension, when stored in refrigerated unit-dosed syringes. NG tube delivery of the 2 products was also investigated. Methods: Five batches of compounded omeprazole oral suspension and 5 kits of FIRST-Omeprazole were prepared to an initial concentration of 2 mg/mL. Suspensions were aliquoted into 5-mL doses in clear plastic oral syringes, and stored at 2-8 °C. Syringes from each batch were analyzed at baseline and after 7, 14, 21, and 30 days for omeprazole potency using HPLC. To assess suitability for NG tube administration, 20 mL of each suspension were administered through NG tubes (8Fr, 10Fr, and 18Fr), and percent omeprazole recovery assessed. Results: The chemical potency remained within 90-110% for 14 days and 30 days for compounded samples and FIRST-Omeprazole samples, respectively. There was a statistically significant difference in initial concentration; 1.89 mg/mL versus 1.98 mg/mL for compounded and FIRST-Omeprazole, respectively. After 30 days, FIRST-Omeprazole demonstrated 97.20% API recovery. Neither suspension experienced statistically significant loss of potency following NG tube passage. Conclusion: FIRST-Omeprazole suspension may be stored in refrigerated clear luer-lock oral syringes for 30 days. Traditionally compounded omeprazole suspension should be used within 14 days. Both suspensions are suitable for NG tube administration.
Rosetting T cells in Hodgkin lymphoma are activated by immunological synapse components HLA class II and CD58
Authors: Veldman Johanna , Visser Lydia , Huberts-Kregel Magdalena , Muller Natasja , Hepkema Bouke , van den Berg Anke , Diepstra Arjan
Published: June 2020

A unique feature of Hodgkin lymphoma (HL) is the presence of CD4+ T cells that surround, protect, and promote survival of tumor cells. The adhesion molecules involved in this so-called T-cell rosetting are important components of the immunological synapse (IS). However, it is unknown whether this synapse is fully assembled and leads to T-cell activation by enabling interaction between the T-cell receptor (TCR) and human leukocyte antigen class II (HLA-II). We established a novel rosetting model by coculturing HLA-II–matched peripheral blood mononuclear cells with HL cell lines and showed IS formation with activation of rosetting T cells. HLA-II downregulation by class II transactivator knockout did not affect the extent of rosetting, but almost completely abrogated T-cell activation. Intriguingly, the level of CD58 expression correlated with the extent of rosette formation, and CD58 knockout or CD2 blockade reduced both rosette formation and T-cell activation. The extension of our findings to primary HL tissue by immunohistochemistry and proximity ligation assays showed interaction of CD2 with CD58 and of TCR-associated CD4 with HLA-II. In conclusion, T-cell rosetting in HL is established by formation of the IS, and activation of rosetting T cells critically depends on the interaction of both TCR-HLA-II and CD2-CD58.
Bridging therapy prior to axicabtagene ciloleucel for relapsed/refractory large B-cell lymphoma
Authors: Pinnix Chelsea C. , Gunther Jillian R. , Dabaja Bouthaina S. , Strati Paolo , Fang Penny , Hawkins Misha C. , Adkins Sherry , Westin Jason , Ahmed Sairah , Fayad Luis , Lee Hun Ju , Nair Ranjit , Steiner Raphael E. , Iyer Swaminathan P. , Rodriguez M. Alma , Wang Michael , Flowers Christopher , Neelapu Sattva S. , Nastoupil Loretta J.
Published: June 2020

The impact of bridging therapy (BT) administered between leukapheresis and chimeric antigen receptor (CAR) T-cell therapy for large B-cell lymphoma (LBCL) is unclear. We evaluated the influence of BT (systemic therapy [ST], radiation therapy [RT], or combined-modality therapy [CMT]) on outcomes of 148 LBCL patients who underwent leukapheresis for planned axicabtagene ciloleucel (axi-cel) infusion. The 55% (n = 81) of patients who received BT were more likely to have international prognostic index (IPI) score ≥3 (P ≤ .01), bulky disease (P = .01), and elevated lactate dehydrogenase (LDH; P ≤ .01). The 1-year progression-free (PFS) and overall survival (OS) rates were 40% and 65% in non-BT patients vs 21% and 48% in BT patients (P = .01 and .05, respectively). Twenty-four patients (16%) did not receive axi-cel, most commonly because of lymphoma progression (88%), despite 80% (n = 19) receiving BT. Among 124 patients who received axi-cel, 50% (n = 62) received BT with ST (n = 45), RT (n = 11), or CMT (n = 6); 1-year PFS and OS rates were not significantly different between BT and non-BT cohorts (P = .06 and .21, respectively). There was no difference in proportion of patients with IPI ≥3, limited-stage disease, or elevated LDH between ST, RT, and CMT groups. Compared with non-BT patients, 1-year PFS was inferior for ST-bridged patients (P = .01). RT-bridged patients had improved PFS compared with ST-bridged patients (P = .05). Despite the poor prognosis associated with requiring BT, RT can be an effective bridging strategy. Future studies are necessary to identify strategies that may improve access to CAR T-cell therapy and outcomes.
Expressive language development in adolescents with Down syndrome and fragile X syndrome: change over time and the role of family-related factors
Authors: del Hoyo Soriano Laura , Thurman Angela John , Harvey Danielle , Kover Sara T. , Abbeduto Leonard
Published: June 2020

Background

It is well known that individuals with Down syndrome (DS) or fragile X syndrome (FXS) demonstrate expressive language difficulties beginning early in childhood. It is less clear, however, whether expressive language skills change during the adolescent period in these individuals, and if any of these changes are syndrome specific. Studying this, as well as the role of maternal and family-related factors in expressive language development, may provide the foundation for efficacious interventions for adolescents with DS or FXS.

Methods

In this study, we examined expressive language trajectories, assessed through conversation and narration, in 57 adolescent males with intellectual disability (ID) (20 DS and 37 FXS) in relation to the diagnostic group (DS vs. FXS) and family-related factors (maternal IQ, maternal psychological distress, closeness in the mother–child relationship, family income, and maternal and paternal education) after adjusting for chronological age (CA) and nonverbal cognition.

Results

Changes over repeated annual assessments for males with DS or FXS were observed only during conversation, such as an increase in talkativeness, but a decrease in syntax complexity and lexical diversity. We found a diagnosis-related effect in the change over time in conversational talkativeness favoring those with FXS. Finally, a closer mother–child relationship predicted less decrease over time in lexical diversity during conversation, and participants of mothers who graduated college showed a greater increase in conversational talkativeness over time compared to those of mothers with a high school education.

Conclusions

Our results suggest that, during the adolescent period for males with DS or FXS, there is an increase in the amount of talk produced in conversational contexts, but also a decrease in the quality of the language produced. In addition, our results indicate syndrome-specificity for aspects of expressive language development and reinforce the protective role of family-related factors.
Coexistence of multiple ureteral and ureterocele stones in a patient
Authors: Turkyilmaz Zafer , Yesil Suleyman , Karabulut Ramazan , Polat Fazli , Seref Kivanc , Oral Hayrunnisa , Sonmez Kaan
Published: June 2020

Background

Uroterocele causes atony and stagnation in the ureter, thus predisposing the patient to stone formation. Multiple calculi in uroteroceles are common in adults but very rare in children.

Case presentation

We describe the case of a 3-year-old boy who presented with hematuria and was found to have multiple ureteral and ureterocele stones. The diagnosis was made during endoscopic lithotripsy. A holmium/yttrium–aluminum–garnet (Ho–YAG) laser was used to excise the uroterocele and for lithotripsy.

Conclusions

In appropriate cases, minimally invasive techniques, for example, Ho–YAG laser lithotripsy and ureterocele excision may be preferred.
High mobilization of CD133+/CD34+ cells expressing HIF-1α and SDF-1α in septic abdominal surgical patients
Authors: Cotoia Antonella , Cela Olga , Palumbo Gaetano , Altamura Sabrina , Marchese Flavia , Mangialetto Nicoletta , La Bella Daniela , Lizzi Vincenzo , Capitanio Nazzareno , Cinnella Gilda
Published: June 2020

Background

The control of endothelial progenitor cells (CD133+/CD34+ EPCs) migrating from bone marrow to peripheral blood is not completely understood. Emerging evidence suggests that stromal cell-derived factor-1α (SDF-1α) mediates egression of EPCs from bone marrow, while the hypoxia inducible factor (HIF) transcriptional system regulates SDF-1α expression. Our study aimed to investigate the time course of circulating CD133+/CD34+ EPCs and its correlation with the expression of HIF-1α protein and SDF-1α in postoperative laparoscopic abdominal septic patients.

Methods

Postoperative patients were divided in control (C group) and septic group (S group) operated immediately after the diagnosis of sepsis/septic shock. Blood samples were collected at baseline (0), 1, 3 and 7 postoperative days for CD133+/CD34+ EPCs count expressing or not the HIF-1α and SDF-1α analysis.

Results

Thirty-two patients in S group and 39 in C group were analyzed. In C group CD133+/CD34+ EPCs count remained stable throughout the study period, increasing on day 7 (173 [0–421] /μl vs baseline: P = 0.04; vs day 1: P = 0.002). In S group CD133+/CD34+ EPCs count levels were higher on day 3 (vs day 1: P = 0.006 and day 7: P = 0.026). HIF-1α expressing CD133+/CD34+ EPCs count decreased on day 1 as compared with the other days in C group (day 0 vs 1: P = 0.003, days 3 and 7 vs 1: P = 0.008), while it was 321 [0–1418] /μl on day 3 (vs day 1; P = 0.004), and 400 [0–587] /μl on day 7 in S group. SDF-1α levels were higher not only on baseline but also on postoperative day 1 in S vs C group (219 [124–337] pg/ml vs 35 [27–325] pg/ml, respectively; P = 0.01).

Conclusion

Our results indicate that sepsis in abdominal laparoscopic patients might constitute an additional trigger of the EPCs mobilization as compared with non-septic surgical patients. A larger mobilization of CD133+/CD34+ EPCs, preceded by enhanced plasmatic SDF-1α, occurs in septic surgical patients regardless of HIF-1α expression therein.

Trial registration

ClinicalTrials.gov no. NCT02589535. Registered 28 October 2015.
The Promotoer, a brain-computer interface-assisted intervention to promote upper limb functional motor recovery after stroke: a study protocol for a randomized controlled trial to test early and long-term efficacy and to identify determinants of response
Authors: Mattia Donatella , Pichiorri Floriana , Colamarino Emma , Masciullo Marcella , Morone Giovanni , Toppi Jlenia , Pisotta Iolanda , Tamburella Federica , Lorusso Matteo , Paolucci Stefano , Puopolo Maria , Cincotti Febo , Molinari Marco
Published: June 2020

Background

Stroke is a leading cause of long-term disability. Cost-effective post-stroke rehabilitation programs for upper limb are critically needed. Brain-Computer Interfaces (BCIs) which enable the modulation of Electroencephalography (EEG) sensorimotor rhythms are promising tools to promote post-stroke recovery of upper limb motor function. The “Promotoer” study intends to boost the application of the EEG-based BCIs in clinical practice providing evidence for a short/long-term efficacy in enhancing post-stroke hand functional motor recovery and quantifiable indices of the participants response to a BCI-based intervention. To these aims, a longitudinal study will be performed in which subacute stroke participants will undergo a hand motor imagery (MI) training assisted by the Promotoer system, an EEG-based BCI system fully compliant with rehabilitation requirements.

Methods

This longitudinal 2-arm randomized controlled superiority trial will include 48 first ever, unilateral, subacute stroke participants, randomly assigned to 2 intervention groups: the BCI-assisted hand MI training and a hand MI training not supported by BCI. Both interventions are delivered (3 weekly session; 6 weeks) as add-on regimen to standard intensive rehabilitation. A multidimensional assessment will be performed at: randomization/pre-intervention, 48 h post-intervention, and at 1, 3 and 6 month/s after end of intervention. Primary outcome measure is the Fugl-Meyer Assessment (FMA, upper extremity) at 48 h post-intervention. Secondary outcome measures include: the upper extremity FMA at follow-up, the Modified Ashworth Scale, the Numeric Rating Scale for pain, the Action Research Arm Test, the National Institute of Health Stroke Scale, the Manual Muscle Test, all collected at the different timepoints as well as neurophysiological and neuroimaging measures.

Discussion

We expect the BCI-based rewarding of hand MI practice to promote long-lasting retention of the early induced improvement in hand motor outcome and also, this clinical improvement to be sustained by a long-lasting neuroplasticity changes harnessed by the BCI-based intervention. Furthermore, the longitudinal multidimensional assessment will address the selection of those stroke participants who best benefit of a BCI-assisted therapy, consistently advancing the transfer of BCIs to a best clinical practice.

Trial registration

Name of registry: BCI-assisted MI Intervention in Subacute Stroke (Promotoer).

Trial registration number:NCT04353297; registration date on the ClinicalTrial.gov platform: April, 15/2020.
Modulating effect of vitamin D status on serum anti-adenovirus 36 antibody amount in children with obesity: National Food and Nutrition Surveillance
Authors: Nikooyeh Bahareh , Hollis Bruce W. , Neyestani Tirang R.
Published: June 2020

Background

The association of ADV-36 infection and obesity has been reported in children.

The objective of this study was to examine the hypothesis that the association between ADV-36 infection and adiposity may be mediated by sub-optimal vitamin D status of the host.

Methods

Ninety one apparently healthy children in different weight categories (normal weight: 33, overweight: 33, obesity: 25) aged 5–18 years were randomly selected from the registered population at National Food and Nutrition Surveillance Program (NFNS). The groups were matched based on age and sex. Anthropometric, biochemical and serological assessments were performed.

Results

The amount of anti-ADV36-Ab increased whereas circulating concentrations of 25(OH) D decreased across BMI categories with higher amounts in children with normal weight than in children with overweight and obesity (31.0 ± 16.4, 22.5 ± 10.5 and 21.9 ± 9.8 nmol/L, respectively, p = 0.004). Logistic regression analysis revealed that for each unit increment of anti-ADV36-Ab, the chance of increase in weight was 8.5 times (OR: 8.5, p = 0.029). Interestingly, when 25(OH) D was introduced into the model, anti-ADV36-Ab was no longer the predictor of weight increment and the chance of increase in weight reduced 5% for each unit increase in 25(OH) D concentration (OR: 0.95, p = 0.012).

Conclusion

It is suggested that ADV36-induced lipogenesis may be mediated by vitamin D deficiency in children with obesity.
The association of depression with child abuse among Indonesian adolescents
Authors: Dhamayanti Meita , Noviandhari Anindita , Masdiani Nina , Pandia Veranita , Sekarwana Nanan
Published: June 2020

Background

Depression is one of the most prevalent mental health problems among adolescents. Mental health problems might be the result of child abuse considering that their prevalences are increasing simultaneously in Indonesia. The aim of this study was to determine the association between depression and a history of abuse among adolescents.

Methods

An analytic cross-sectional study was conducted on 786 junior high school students from Bandung City, West Java, Indonesia. Subjects were selected using two-stage cluster sampling. The Children’s Depression Inventory (CDI) and the ISPCAN Child Abuse Screening Tool (ICAST) questionnaires were applied to assess depression and a history of abuse, respectively. Depression was diagnosed by a psychiatrist after a positive score on the CDI. The data were analysed using chi-square tests and multiple regression.

Results

A history of child abuse was associated with depression in adolescents. All dimensions of child abuse had a significant association with depression. Psychological violence had the highest risk factor for the occurrence of depression (PR = 6.51), followed by exposure to violence and physical violence. Sexual violence was not a common dimension of child abuse among students. Psychological violence had the strongest association with depression, and victims were three times more likely to develop depression (POR = 3.302, p = 0.004).

Conclusion

Psychological violence was proven to be a strong risk factor for developing depression symptoms among adolescent students. While each victimization domain remained a significant predictor of depression, the experience of multiple domains during a child’s life-course may predict mental health risk. Early detection and interventions to prevent abuse and its consequences are critical.
Prognostic significance of MYCN related genes in pediatric neuroblastoma: a study based on TARGET and GEO datasets
Authors: Wang Haiwei , Wang Xinrui , Xu Liangpu , Zhang Ji , Cao Hua
Published: June 2020

Background

Neuroblastoma patients with MYCN amplification are associated with poor prognosis. However, the prognostic relevance of MYCN associated genes in neuroblastoma is unclear.

Methods

The expression profiles of MYCN associated genes were identified from Therapeutically Applicable Research to Generate Effective Treatments (TARGET) and Gene Expression Omnibus (GEO) datasets. Enriched transcription factors and signaling pathways were determined using gene set enrichment analysis (GSEA). Kaplan-Meier plotter was used to identify the prognostic relevance of MYCN associated genes. Multivariate cox regression and Spearman’s correlation were used to determine the correlation coefficients of MYCN associated genes.

Results

In TARGET and GSE85047 datasets, neuroblastoma patients with MYCN amplification were associated with worse prognosis. Transcription factor MYC was positively associated with MYCN amplification in GSEA assay. We identified 13 MYC target genes which were increased in neuroblastoma patients with MYCN amplification in TARGET, GSE19274 and GSE85047 datasets. Moreover, six out of the 13 MYC target genes ARMC6, DCTPP1, EIF4G1, ELOVL6, FBL and PRMT1 were associated with adverse prognosis in TARGET and GSE85047 datasets. Transcription factor E2F1 was up-regulated by MYCN amplification and associated with the poor prognosis of neuroblastoma. Furthermore, RPS19 in ribosome signaling pathway was also associated with MYCN amplification and correlated with the poor prognosis of neuroblastoma. At last, we showed that most of MYCN target genes were correlated with each other. However, EIF4G1 was an independent prognostic marker. And the prognostic effects of the combination of MYCN amplification and EIF4G1 expression were more significant than MYCN or EIF4G1 alone.

Conclusions

MYCN target genes ARMC6, DCTPP1, EIF4G1, ELOVL6, FBL, PRMT1, E2F1 and RPS19 had significant prognostic effects in pediatric neuroblastoma. And neuroblastoma patients without MYCN amplification and low EIF4G1 expression had best prognosis.
Correction to: The complex neurobiology of resilient functioning after childhood maltreatment
Authors: Ioannidis Konstantinos , Askelund Adrian Dahl , Kievit Rogier A. , van Harmelen Anne-Laura
Published: June 2020

An amendment to this paper has been published and can be accessed via the original article.
Correction to: microRNA-124 inhibits bone metastasis of breast cancer by repressing Interleukin-11
Authors: Cai Wei-Luo , Huang Wen-Ding , Li Bo , Chen Tian-Rui , Li Zhen-Xi , Zhao Cheng-Long , Li Heng-Yu , Wu Yan-Mei , Yan Wang-Jun , Xiao Jian-Ru
Published: June 2020

An amendment to this paper has been published and can be accessed via the original article.
Virtual follow-up and care for patients with cardiac electronic implantable devices: protocol for a systematic review
Authors: Kelly Shannon E. , Clifford Tammy J. , Coyle Doug , Martin Janet , Welch Vivian , Skidmore Becky , Birnie David , Parkash Ratika , Tang Anthony S. L. , Wells George A.
Published: June 2020

Background

Capacity to deliver outpatient care for patients with cardiac implantable electronic devices (CIEDs) may soon be outweighed by need. This systematic review aims to investigate the comparative effectiveness, safety, and cost for virtual or remote clinic interventions for patients with CIEDs and explores how outcomes may be influenced by patient or system factors in-depth.

Methods

We will perform a systematic literature search in MEDLINE, Embase, PsycINFO, CINAHL, Proquest Dissertations & Theses, other EBM Reviews, and trial registry databases. Two authors will independently screen titles and abstracts for eligibility. We will include randomized and non-randomized controlled trials, quasi-randomized and experimental studies, cohort, and case-control studies. Study populations of interest are individuals with a CIED (pacemaker, ICD, CRT). Eligibility will be restricted to virtual or remote follow-up or care interventions compared to any other approach. The co-primary outcomes of interest are mortality and patient satisfaction. Secondary outcomes include clinical effectiveness (e.g., ICD shock, time-to-detection of medical event, hospitalizations), safety (e.g., serious or device-related adverse events), device efficacy (e.g., transmissions, malfunctions), costs, workflow (e.g., resources, process outcomes, time-saved), and patient reported (e.g., burden, quality of life). Data will be extracted by one author and checked by a second using a standardized template. We will use published frameworks to capture data relevant to intervention effects that may be influenced by intervention definition or complexity, context and setting, or in socially disadvantaged populations. Detailed descriptive results will be presented for all included studies and outcomes, and where feasible, synthesized using meta-analysis. Risk of bias will be assessed by two review authors independently using Cochrane Risk of Bias tools. Certainty of evidence will be assessed using the GRADE approach.

Discussion

Increases in number of CIEDs implanted, combined with an aging population and finite health resource allocations at the system-level may lead to increased reliance on virtual follow-up or care models in the future. These models must prioritize consistent, equitable, and timely care as a priority. Results from this systematic review will provide important insight into the potential contextual factors which moderate or mediate the effectiveness, safety, and cost of virtual follow-up or care models for patients.

Systematic review registration

PROSPERO registration number CRD42020145210
Active Women over 50 online information and support to promote physical activity behaviour change: study protocol for a pilot trial
Authors: Wallbank Geraldine , Sherrington Catherine , Hassett Leanne , Kwasnicka Dominika , Chau Josephine Y. , Martin Fiona , Phongsavan Philayrath , Grunseit Anne , Canning Colleen , Baird Marian , Shepherd Roberta , Tiedemann Anne
Published: June 2020

Background

Physical activity has many physical and mental health benefits and can delay the development of disability in older age. However, uptake of this health behaviour is sub-optimal in women in their middle and older age. This trial aims to establish the acceptability and feasibility of the Active Women over 50 programme involving online information, telephone health coaching and email or SMS support to promote physical activity behaviour change among women aged 50 years and over.

Methods

Sixty community-dwelling women who are insufficiently active according to national guidelines, will be recruited and randomised to 1) receive the Active Women over 50 programme or 2) a wait-list control. Active Women over 50 is a 3-month physical activity programme guided by behaviour change science, providing access to a website, one telephone-delivered health coaching session from a physiotherapist and 8 email or 24 SMS messages. The primary outcome is the proportion of participants at 3 months post-randomisation who would recommend participation in the programme to another person like themselves. Secondary outcomes are feasibility measures: rates of recruitment, retention, completeness of outcome data and uptake of telephone support; and intervention impact measures: accelerometer-assessed average steps/day, proportion of participants meeting national guidelines on moderate to vigorous physical activity; and questionnaire-assessed quality of life, exercise perceptions, mood, physical functioning and self-reported physical activity. Intervention participants will also complete a follow-up survey to assess impressions of the intervention and adoption of strategies for physical activity participation. Data will be analysed descriptively to guide the design of a larger trial. Between-group differences in secondary outcomes will be used to estimate effect sizes for sample size calculations for a fully powered randomised controlled trial.

Discussion

This feasibility pilot trial of an efficient eHealth and health coaching intervention guided by user input and behaviour change theory, will inform future interventions to address low physical activity participation among an under-active group at risk of future disability.

Trial registration

ANZCTR, ACTRN12619000490178, registered 26 March 2019
Engineering and humanitarian intervention: learning from failure
Authors: Arshad-Ayaz Adeela , Naseem M. Ayaz , Mohamad Dania
Published: June 2020

In this paper, we challenge the belief that failure is necessarily a bad outcome. Instead, we argue that failure—specifically articulated as productive failure—should rather be seen as an educational moment and learning opportunity. Furthermore, we examine the field of humanitarian engineering to argue that the failures of various humanitarian engineering interventions are not necessarily because of flaws in the design process but due to the dominance of the mainstream development discourse, which obscures the importance of local contexts, knowledge, and wisdom. We ground the discussion in the broader context of contemporary development discourses and examine some examples of the failure of engineering and humanitarian assistance/development projects that can be converted into “productive failures” and used as learning opportunities.
Unraveling the puzzle of the origin and evolution of cotton A-genome
Authors: MA Zhiying
Published: June 2020

Gossypium hirsutum, the most widely planted cotton species, its evolution has long been an unsolved puzzle because of its hybrid origin from D-genome and A-genome species. To better understand the genetic component of cotton, Huang et al. recently sequenced and assembled the first A1-genome G. herbaceum, and updated the A2-genome G. arboreum and (AD)1-genome G. hirsutum. On the basis of the three reference genomes, they resolved existing controversial concepts and provided novel evolutionary insights surrounding the A-genome.
Applying plant-based irrigation scheduling to assess water use efficiency of cotton following a high-biomass rye cover crop
Authors: MEEKS Calvin D. , SNIDER John L. , CULPEPPER Stanley , HAWKINS Gary
Published: June 2020

Background

This study addressed the potential of combining a high biomass rye winter cover crop with predawn leaf water potential (ΨPD) irrigation thresholds to increase agricultural water use efficiency (WUE) in cotton. To this end, a study was conducted near Tifton, Georgia under a manually-controlled, variable-rate lateral irrigation system using a Scholander pressure chamber approach to measure leaf water potential and impose varying irrigation scheduling treatments during the growing season. ΨPDthresholds were − 0.4 MPa (T1), − 0.5 MPa (T2), and − 0.7 MPa (T3). A winter rye cover crop or conventional tillage were utilized for T1-T3 as well.

Results

Reductions in irrigation of up to 10% were noted in this study for the driest threshold (− 0.7 MPa) with no reduction in lint yield relative to the − 0.4 MPa and − 0.5 MPa thresholds. Drier conditions during flowering (2014) limited plant growth and node production, hastened cutout, and decreased yield and WUE relative to 2015.

Conclusions

We conclude that ΨPDirrigation thresholds between − 0.5 MPa and − 0.7 MPa appear to be viable for use in a ΨPDscheduling system with adequate yield and WUE for cotton production in the southeastern U.S. Rye cover positively impacted water potential at certain points throughout the growing season but not yield or WUE indicating the potential for rye cover crops to improve water use efficiency should be tested under longer-term production scenarios.
Co-administration of 5α-reductase Inhibitors Worsens the Adverse Metabolic Effects of Prescribed Glucocorticoids
Authors: Othonos Nantia , Marjot Thomas , Woods Conor , Hazlehurst Jonathan M , Nikolaou Nikolaos , Pofi Riccardo , White Sarah , Bonaventura Ilaria , Webster Craig , Duffy Joanne , Cornfield Thomas , Moolla Ahmad , Isidori Andrea M , Hodson Leanne , Tomlinson Jeremy W
Published: June 2020

Context

Glucocorticoids (GCs) are commonly prescribed, but their use is associated with adverse metabolic effects. 5α-reductase inhibitors (5α-RI) are also frequently prescribed, mainly to inhibit testosterone conversion to dihydrotestosterone. However, they also prevent the inactivation of GCs.

Objective

We hypothesized that 5α-RI may worsen the adverse effects of GCs.

Design

Prospective, randomized study.

Patients

A total of 19 healthy male volunteers (age 45 ± 2 years; body mass index 27.1 ± 0.7kg/m2).

Interventions

Participants underwent metabolic assessments; 2-step hyperinsulinemic, euglycemic clamp incorporating stable isotopes, adipose tissue microdialysis, and biopsy. Participants were then randomized to either prednisolone (10 mg daily) or prednisolone (10 mg daily) plus a 5α-RI (finasteride 5 mg daily or dutasteride 0.5 mg daily) for 7 days; metabolic assessments were then repeated.

Main Outcome Measures

Ra glucose, glucose utilization (M-value), glucose oxidation, and nonesterified fatty acids (NEFA) levels.

Results

Co-administration of prednisolone with a 5α-RI increased circulating prednisolone levels (482 ± 96 vs 761 ± 57 nmol/L, P = 0.029). Prednisolone alone did not alter Ra glucose (2.55 ± 0.34 vs 2.62 ± 0.19 mg/kg/minute, P = 0.86), M-value (3.2 ± 0.5 vs 2.7 ± 0.7 mg/kg/minute, P = 0.37), or glucose oxidation (0.042 ± 0.007 vs 0.040 ± 0.004 mmol/hr/kg/minute, P = 0.79). However, co-administration with a 5α-RI increased Ra glucose (2.67 ± 0.16 vs 3.05 ± 0.18 mg/kg/minute, P < 0.05) and decreased M-value (4.0 ± 0.5 vs 2.6 ± 0.4 mg/kg/minute, P < 0.05), and oxidation (0.043 ± 0.003 vs 0.036 ± 0.002 mmol/hr/kg, P < 0.01). Similarly, prednisolone did not impair insulin-mediated suppression of circulating NEFA (43.1 ± 28.9 vs 36.8 ± 14.3 μmol/L, P = 0.81), unless co-administered with a 5α-RI (49.8 ± 8.6 vs 88.5 ± 13.5 μmol/L, P < 0.01).

Conclusions

We have demonstrated that 5α-RIs exacerbate the adverse effects of prednisolone. This study has significant translational implications, including the need to consider GC dose adjustments, but also the necessity for increased vigilance for the development of adverse effects.