bluuebunny/crossref_metadata_2025 huggingface dataset:
Educação Ambiental como Temática Transversal: Concepções dos Coordenadores de uma Rede Pública
Authors: Carvalho Júnior Expedicto Ribeiro de , Tomachuk Célia Regina , Neto Morun Bernardino
Published: July 2022

A Educação Ambiental (EA) vista sob a ótica emancipatória e libertadora é aquela que leva em consideração aspectos éticos, estéticos, políticos, econômicos, culturais e ambientais. Nesse sentido, a EA como transversalidade está entre, atravessa e se projeta além das disciplinas do currículo, constituindo eixo transversal e deflagradora de problemas cujas reflexões estão para além dos conhecimentos contidos em uma única disciplina curricular. Dentro dessa concepção, será que os coordenadores pedagógicos que atuam nas escolas públicas municipais de uma cidade do Vale do Paraíba entendem a EA nessa perspectiva transversal? A abordagem dessa pesquisa teve como método a aplicação de um questionário estruturado elaborado em escala Likert com análise de variância de postos de Kruskal-Wallis e pós-teste de Student-Newman-Keuls aos 41 coordenadores pedagógicos da rede de ensino em questão. Para melhor compreender os resultados, os coordenadores foram divididos em três grupos, ou seja, os que atuam em escolas rurais, urbanas e centrais e urbanas e periféricas. Os resultados apontaram para uma concepção dos coordenadores para uma pseudotransversalidade, indicando que enquanto concepção há um entendimento da necessidade de uma abordagem dessa temática no campo transversal, mas que na prática cotidiana ela não ocorre, implicando uma ação educadora fragmentada, cognicista e massificada.
Emerging Trends in Bioinformatics for Breast Cancer Molecular Research
Authors: Mandape Sammed N.
Published: July 2022

Applications of bioinformatic methods and high-throughput sequencing
techniques have increased exponentially over the last decade, transforming the way we
understand complex malignancies such as breast cancer. In this chapter, an overview of
recent advances in molecular research in breast cancer using emerging bioinformatics
methods is presented. Learnings from scientific studies that have successfully
integrated and interpreted massive amounts of data generated from various platforms
(multi-omics data) using bioinformatics approaches are also outlined. Additionally,
pan-cancer studies that help identify the differences and commonalities across multiple
cancers are reviewed. We also discuss bioinformatics applications that transform the
way we decipher the OncoGenomic landscape of breast cancer. Finally, this study also
summarizes current publicly available bioinformatics tools and databases for breast
cancer research.
Role of Nitric Oxide in Breast Cancer
Authors: Khan Ekhlaque A. , Parwez Akhtar
Published: July 2022

Nitric oxide (NO) is a universal, water-soluble, free radical gas, which plays
an important role in the physiological along with pathological processes. NO has been
shown in the literature as a key player in carcinogenesis as well as tumor development.
Still, there is a lot of debate and misunderstanding about its involvement in cancer. It is
believed to have both tumoricidal as well as tumor-promoting effects, which are
determined by its timing, location, and concentration. NO has been linked to
angiogenesis, apoptosis, cell cycle, invasion, and metastasis. On the other hand, it is
emerging as a possible anti-oncogenic agent. Strategies for manipulating in vivo
production and exogenous delivery of this molecule for therapeutic gain are being
investigated. For therapeutic advantage, strategies for controlling in vivo synthesis and
exogenous distribution of this molecule are being investigated. Further research in
experimental settings and clinical trials is required to enhance innovative NO-based
cancer prevention and treatment strategies. The spectrum of NO actions in cancer and
the mechanisms by which NO acts in breast cancer are addressed in this article.
Dietary Polyphenols and its Molecular Mechanism in the Management of Breast Cancer
Authors: Rai Girish , Shekhar Sudhir Kumar
Published: July 2022

Despite clinical and pharmacological advancement in medical science breast
cancer has become a global concern due to the high mortality rate. Breast cancer is
mainly associated with altered redox status, cell cycle, chronic inflammation, and
increased proliferative rate. Breast cancer has various molecular subtypes and adequate
knowledge of these altered cell cycle regulatory cascades and molecular subtypes of
breast cancer is a must for proper prognosis and its successful treatment. The discovery
of drugs with anticancer properties, particularly against the specific subtype of breast
cancer has become a challenging task for cancer researchers. Dietary polyphenolic
compounds as cancer chemopreventive agents have drawn much attention among
researchers because polyphenolic compounds are natural in origin with lesser side
effects and have a wide range of action against various subtypes of breast cancer.
Dietary compounds with antioxidant properties have been reported to act on an array of
genes and proteins associated with breast cancer pathogenesis and thus regulate the
signaling cascade related to autophagy, chronic inflammation, apoptosis, and cell cycle
regulation. All in all, these natural compounds regulate growth and progression of a
tumour with less or no side effects. Thus, the current article focuses primarily here on
various aspects of breast cancer and food polyphenolic compounds as wellas their
molecular mechanism for managing breast cancer.
Editorial. CRISPR: 10 años de su descubrimiento, un Premio Nobel y en proceso, el aprendizaje de edición de genes
Authors: Hernández Fernández Javier
Published: July 2022

El 28 de junio de 2012 seis autores publicaron el artículo A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity, con dos autoras para correspondencia: las genetistas Jennifer A. Doudna y Emmanuelle Charpentier, quienes recibieron el Premio Nobel de Química en 2020 por el descubrimiento. En esta década de investigación con Crispr (Clustered Regularly Interspaced Short Palindromic Repeats o, en español, Repeticiones Palindrómicas Cortas Agrupadas y Regularmente Espaciadas), ha evolucionado a tal punto de convertirse en uno de los hallazgos más importantes de la biología molecular moderna. Con la técnica desarrollada se puede hacer edición de genes o cirugía molecular o alteración del adn en humanos, plantas, animales y microorganismos.
Comptuer Based Instruction (CBI)-flipped classroom development in learning: The experts' validity
Authors: Sakti Rizki Hardian , Sukardi Sukardi
Published: July 2022

Technology has reached a level where it is time for genuine education reforms that increase student content attainment by teaching lessons relevant to the 4.0 industrial revolution. Generation Z students prefer to use technology in learning because, in the digitalization era, students raised on new media technology are impatient if they only fill out worksheets and listen to lectures. However, based on the observation, many students are bored of instructional media implemented in learning is not computer-based innovative and creative media. Therefore, the CBE-Flipped classroom is a computer-based learning media solution that is relevant to the development of learning in the 4.0 industrial revolution. After developing the CBE-Flipped Classroom, researchers need to know whether the CBE-flipped classroom is what is expected. Researchers also need a paradigm of whether they have developed a valid CBE-flipped classroom so that the CBE-flipped classroom can be applied effectively as an instructional media in the classroom during the learning process. So, this study aims at describing the expert validity of CBE-Flipped Classroom before implementing it in the learning process. Based on the results of the study, it can be concluded that the media design has been valid in terms of didactic, construction, and technical aspects. While the results of material validation also indicated that the material on the media has been valid in terms of quality of content, learning, interaction, and appearance. It can be concluded that the CBE-Flipped Classroom can be applied effectively as an instructional media in the classroom during the learning process.
Analisis kemitraan guru dan orang tua dalam pembentukan karakter anak berdasarkan Kurikulum 2013 di SMA
Authors: Handayani Ilen Putri , Hasrul Hasrul
Published: July 2022

Permasalahan  kareakter anak sangat beragam di Sekolah Menengah Pertama (SMA), mulai dari displin, sampai dengan juga toleransi, sehingga diperlukan kemitraan guru dan orang tua dalam membentuk karakter anak. Metode penelitian yang digunakan adalah metode penelitian deskriptif dengan menggunakan pendekatan kualitatif. Lokasi penelitian dilakukan di SMA N 2 Ranah Pesisir. Pengambilan sampel penelitian menggunakan teknik purposive sampling. Teknik pengumpulan data dalam penelitian ini menggunakan dua cara, yaitu wawancara terstruktur dan observasi. Sumber data dalam penelitian ini adalah data primer dan data sekunder. Teknik analisis data yang digunakan dalam penelitian ini adalah model interaktif analisis Miles dan Hiberman. Hasil penelitian ini menunjukkan bahwa: kemitraan guru dan orang tua dalam pembentukan karakter anak berdasarkan kurikulum 2013 di SMA guru dan orang tua siswa dalam bekerjasama membentuk karakter anak dengan selalu mengarkan bersyukur dengan pemberian orang lain, perilaku jujur, disiplin, tanggung jawab, peduli, santun, ramah lingkungan, gotong royong, kerjasama, dan menunjukan sikap dalam berinteraksi secara efektif dengan lingkungan dan alam, serta dalam menempatkan diri sebagai cerminan bangsa dalam pergaulan, suka bergaul dengan teman-teman, ramah, dan gotongroyong, dan bersosilisasi dengan masyarakat yang berlandasrkan kurikulum 2013.Analysis of the partnership between teachers and parents in the formation of children's character based on the 2013 Curriculum in SMA AbstractThe problem of children's character is very diverse in high school, ranging from discipline to tolerance, so a partnership between teachers and parents is needed in shaping children's character. The location of the research was carried out at SMA N 2 Ranah Pesisir. The research sample was taken using the purposive sampling technique. Data collection techniques in this study used two ways, namely structured interviews and observation. Sources of data in this study are primary data and secondary data. The data analysis technique used in this research is the interactive model of Miles and Huberman's analysis. The results showed that: The partnership of teachers and parents in shaping the character of children based on the 2013 curriculum in high school teachers and parents of students in working together to shape children's character by always showing gratitude with the gifts of others, honest behavior, discipline, responsibility, caring, polite, environmentally friendly, mutual cooperation, cooperation, and showing attitudes in interacting effectively with the environment and nature as well as in placing oneself as a reflection of the nation in association, likes to hang out with friends, friendly, and mutual cooperation, and socialize with the community based on the 2013 curriculum.
Pemberdayaan masyarakat Indonesia melalui pendidikan nonformal: Sebuah kajian pustaka
Authors: Laila Dinda Alifatul , Salahudin Salahudin
Published: July 2022

Penelitian ini bertujuan untuk melihat bagaimana pemberdayaan masyarakat melalui pendidikan nonformal di Indonesia. Penelitian ini menggunakan metode kajian pustaka dengan cara menguraikan, merangkum, dan mengkonstruk gagasan teori maupun hasil penelitian yang relevan. Data yang didapatkan bersumber dari kumpulan beberapa artikel-artikel yang dipublikasikan pada jurnal ilmiah yang berstandar internasional dengan menggunakan kata kunci “empowerment of Indonesia society through non-formal education”, dengan mengajukan beberapa pertanyaan yang akan digunakan sebagai referensi untuk studi berdasarkan penemuan artikel pada basis data Scopus. Pada penelitian ini mengungkapkan bahwa, tingginya angka kemiskinan dan angka putus sekolah di Indonesia maka pemberdayaan melalui pendidikan nonformal digunakan sebagai solusi agar tiap masyarakat mempunyai kemampuan dan kredibilitas yang sama demi mensejahterakan dirinya juga negara. Dengan itu angka kemiskinan dan angka putus sekolah anak dapat menurun. Keberadaan pendidikan nonformal di harapkan mampu untuk memcahkan masalah yang ada di Indonesia terutama pada masalah ekonomi dan lapangan pekerjaan. Diharapkan pula kursus dan pelatihan yang diselenggarakan sebagai pendidikan nonformal di Indonesia dapat mencapai kompetensi dan sebagai pemanfaatan teknologi mengingat saat ini sudah berada pada era revolusi indutri 4.0 dimana persaingan akan semakin ketat.AbstractThis study aims to see how community empowerment through non-formal education in Indonesia. This study uses a literature review method by describing, summarizing, and constructing theoretical ideas and relevant research results. The data obtained is sourced from several articles published in scientific journals with international standards using the keyword "empowerment of Indonesian society through non-formal education" by asking several questions that will be used as references for studies based on article findings on Scopus data. This study reveals that, due to the high poverty rate and dropout rate in Indonesia, empowerment through non-formal education is used as a solution so that every community has the same ability and credibility for their welfare and the country. This will reduce the poverty rate and dropout rate for children. The existence of non-formal education is expected to solve problems in Indonesia, especially in terms of economic problems and employment. It is also hoped that courses and training held as non-formal education in Indonesia can achieve competence and the use of technology, considering that we are currently in the era of the industrial revolution 4.0, where the competition will be even tighter.
Observasi keterampilan bertanya mahasiswa melalui implementasi Student Questioning Card (SQC)
Authors: Syazali Muhammad , Nursaptini Nursaptini
Published: July 2022

Kemampuan komunikasi merupakan salah satu tantangan di abad ke-21. Keterampilan bertanya juga dibutuhkan oleh mahasiswa calon guru. Di Program Studi Pendidikan Guru Sekolah Dasar (PGSD) FKIP Universitas Mataram, kemampuan tersebut sulit dieksplorasi karena fasilitas pembelajaran yang selama ini diimplementasikan belum dapat menjangkau seluruh mahasiswa untuk bertanya selama perkuliahan tatap muka maupun pembelajaran daring. Penelitian bertujuan untuk mendeskripsikan keterampilan bertanya mahasiswa melalui implementasi Student Questioning Card (SQC). Sampel terdiri dari 35 mahasiswa Program Studi PGSD FKIP Universitas Mataram yang dipilih secara random. Untuk mengoleksi pertanyaan, setiap mahasiswa menuliskan minimal 3 pertanyaan di SQC selama perkuliahan berlangsung. Kualitas pertanyaan dinilai dari aspek kesesuaian dengan topik makalah, struktur bahasa, dan tingkatan kognitif berdasarkan taksonomi Bloom hasil revisi. Kami menemukan bahwa kualitas pertanyaan mahasiswa berada pada kategori tidak baik di atas 61%. Proporsi HOTS pada kelompok pertanyaan benar sebesar 34.25%, dan LOTS sebesar 65.75 %. Untuk Proporsi HOTS pada kelompok pertanyaan kurang benar sebesar 22.38%, dan LOTS sebesar 77.62 %. Adapun pada kelompok pertanyaan yang salah HOTS sebesar 37.93%, dan LOTS sebesar 62.07 %.AbstractCommunication skills are one of the challenges in the 21st century. Asking skills are also needed by prospective teacher students in the Elementary School Teacher Education Study Program (PGSD) at FKIP University of Mataram. This ability is difficult to explore because the learning facilities that have been implemented so far have not been able to reach all students to ask questions during face-to-face lectures or online learning. This study aims to describe students' questioning skills through the implementation of the Student Questioning Card (SQC). The sample consisted of 35 students of the PGSD FKIP University of Mataram who were randomly selected. Each student writes down at least three questions in SQC during the lecture to collect questions. The quality of the questions was assessed from the aspect of suitability with the paper's topic, language structure, and cognitive level based on Bloom's revised taxonomy. We found that the quality of student questions was in the poor category, above 61%. The proportion of HOTS in the correct question group is 34.25%, and LOTS is 65.75%. The proportion of HOTS in the question group that is less true is 22.38%, and LOTS is 77.62%. As for the wrong question group, HOTS is 37.93%, and LOTS is 62.07%.
Contrasting the Expectations and Experiences Related to Mobile Health Use for Chronic Pain: Questionnaire Study
Authors: Kheirinejad Saba , Alorwu Andy , Visuri Aku , Hosio Simo
Published: July 2022

Background

Chronic pain is a prolonged condition that deteriorates one's quality of life. Treating chronic pain requires a multicomponent approach, and in many cases, there are no “silver bullet” solutions. Mobile health (mHealth) is a rapidly expanding category of solutions in digital health with proven potential in chronic pain management.

Objective

This study aims to contrast the viewpoints of 2 groups of people with chronic pain concerning mHealth: people who have adopted the use of mHealth and those who have not. We highlight the benefits of mHealth solutions for people with chronic pain and the perceived obstacles to their increased adoption. We also provide recommendations to encourage people to try mHealth solutions as part of their self-care.

Methods

The Prolific crowdsourcing platform was used to collect crowdsourced data. A prescreening questionnaire was released to determine what type of pain potential participants have and whether they are currently using mHealth solutions for chronic pain. The participants were invited based on their experience using mHealth to manage their pain. Similar questions were presented to mHealth users and nonusers. Qualitative and quantitative analyses were performed to determine the outcomes of this study.

Results

In total, 31 responses were collected from people (aged 19-63 years, mean 31.4, SD 12.1) with chronic pain who use mHealth solutions. Two-thirds (n=20, 65%) of the users identified as female and 11 (35%) as male. We matched these mHealth users with an equal number of nonusers: 31 responses from the pool of 361 participants in the prescreening questionnaire. The nonusers’ ages ranged from 18 to 58 years (mean 30.8, SD 11.09), with 15 (50%) identifying as female and 15 (50%) as male. Likert-scale questions were analyzed using the Mann-Whitney-Wilcoxon (MWW) test. Results showed that the 2 groups differed significantly on 10 (43%) of 23 questions and shared similar views in the remaining 13 (57%). The most significant differences were related to privacy and interactions with health professionals. Of the 31 mHealth users, 12 (39%) declared that using mHealth solutions has made interacting with health or social care professionals easier (vs n=22, 71%, of nonusers). The majority of the nonusers (n=26, 84%) compared with about half of the users (n=15, 48%) expressed concern about sharing their data with, for example, third parties.

Conclusions

This study investigated how mHealth is currently used in the context of chronic pain and what expectations mHealth nonusers have for mHealth as a future chronic pain management tool. Analysis revealed contrasts between mHealth use expectations and actual usage experiences, highlighting privacy concerns toward mHealth solutions. Generally, the results showed that nonusers are more concerned about data privacy and expect mHealth to facilitate interacting with health professionals. The users, in contrast, feel that such connections do not exist.
Factors Influencing How Providers Assess the Appropriateness of Video Visits: Interview Study With Primary and Specialty Health Care Providers
Authors: Gray Caroline , Wray Charlie , Tisdale Rebecca , Chaudary Camila , Slightam Cindie , Zulman Donna
Published: July 2022

Background

The rapid implementation of virtual care (ie, telephone or video-based clinic appointments) during the COVID-19 pandemic resulted in many providers offering virtual care with little or no formal training and without clinical guidelines and tools to assist with decision-making. As new guidelines for virtual care provision take shape, it is critical that they are informed by an in-depth understanding of how providers make decisions about virtual care in their clinical practices.

Objective

In this paper, we sought to identify the most salient factors that influence how providers decide when to offer patients video appointments instead of or in conjunction with in-person care.

Methods

We conducted semistructured interviews with 28 purposefully selected primary and specialty health care providers from the US Department of Veteran’s Affairs health care system. We used an inductive approach to identify factors that impact provider decision-making.

Results

Qualitative analysis revealed distinct clinical, patient, and provider factors that influence provider decisions to initiate or continue with virtual visits. Clinical factors include patient acuity, the need for additional tests or labs, changes in patients’ health status, and whether the patient is new or has no recent visit. Patient factors include patients’ ability to articulate symptoms or needs, availability and accessibility of technology, preferences for or against virtual visits, and access to caregiver assistance. Provider factors include provider comfort with and acceptance of virtual technology as well as virtual physical exam skills and training.

Conclusions

Providers within the US Department of Veterans Affairs health administration system consider a complex set of factors when deciding whether to offer or continue a video or telephone visit. These factors can inform the development and further refinement of decision tools, guides, and other policies to ensure that virtual care expands access to high-quality care.
Testing English Speakers’ Perception of Arabic Contrasts
Authors: Alsuhaibani Alwaleed A.
Published: July 2022

This paper presents the results of an experiment conducted to investigate how adult native speakers of English perceive some Arabic contrasts within Brown’s Phonological Interference Model (PIM) (1998, 2000), based on the theory of Feature Geometry. Three Arabic pairs of contrasts were chosen for the experiment: the contrast /b – d/ consisting of consonants present in both English and Arabic; the contrast /x – ?/ consisting of consonants that are non-native to English but are distinguished by the features [dorsal, voice, continuant] which are available in the English feature geometry; and finally the contrast /h – ?/, of which only the former exists in English, whereas the latter is non-native to English and is distinguished by the feature [RTR], which is unavailable in the English feature geometry, thereby rendering /?/ completely alien to the English sound system. The experiment consisted of an AX Discrimination task where subjects heard two sounds and were asked to decide whether they were the same or different. Three groups participated in the experiment: an Arabic L1 control group, an English L1 group, and finally an Arabic L2 group. The results of the experiment confirm Brown’s findings in a similar experiment with Japanese and Chinese speakers’ perception of English.
TRANSDERMAL PATCHES FOR THE TREATMENT OF ANGINA PECTORIS: AN EFFECTIVE DRUG DELIVERY SYSTEM-A REVIEW
Authors: KUMAR CH. ANIL , ASHWINI J. , G. L. ARCHANA , LAXMI SEPURI VIJAYA , GARIGE ANIL KUMAR , CHANDUPATLA VIJITHA , HAQUE M. AKIFUL , KHAN SHARUK L.
Published: July 2022

Topical delivery methods have been used since the dawn of time, employed to cure a wide range of ailments and for aesthetic purposes. Transdermal drug delivery has evolved throughout time, with the development of passive and active technologies that have resulted in enhanced distribution, accuracy in drug dosage, and better fulfilment of the requirements of the individual. The search for more powerful pharmaceuticals that can be delivered to the skin through appropriate transdermal technologies will continue to be a focus in the development of drugs for transdermal patches and other forms of delivery. Topical and transdermal distribution has been around for a while, but this review will focus on transdermal patches and how they've evolved. The articles have been searched on different search engines such as Scopus database, Science direct, PubMed, Google scholar, and Bentham science using multiple keywords. An adhesive transdermal patch is applied to the skin and contains medicine that is absorbed into the bloodstream through the skin. It aids in the recovery of an afflicted part of the body. When compared to oral, topical, i. v., and i. m. administration systems, transdermal drug delivery allows a controlled release of the medicine into patients, often by either a porous membrane or by body heat melting small layers of medication embedded in the adhesive. The fundamental drawback of transdermal delivery methods is that the skin is a highly efficient barrier, therefore, only tiny molecules can enter the skin and be administered in this manner.
PHARMACEUTICAL EQUIVALENCE OF METRONIDAZOLE TABLETS USING THE FLOW-THROUGH CELL (USP APPARATUS 4) AND MEDIA OF PHYSIOLOGICAL pH RANGE
Authors: JIMENEZ-FLORES YADIRA , HURTADO MARCELA , MEDINA-LOPEZ JOSE RAUL
Published: July 2022

Objective: The aim of this work was to evaluate the pharmaceutical equivalence of metronidazole tablets through the study of hydrodynamics of the flow-through cell (USP Apparatus 4) on the dissolution performance of four commercial formulations (500 mg). The results were compared with those found using the USP basket apparatus.
Methods: Experiments were performed with 0.1 N hydrochloric acid (pH 1.2), acetate buffer pH 4.5 and phosphate buffer pH 6.8. A USP Apparatus 4 was used with laminar flow at 16 ml/min and 22.6-mm cells. USP basket apparatus was used with 900 ml of each dissolution medium. The dissolution profiles were compared in terms of the mean dissolution time and dissolution efficiency.
Results: Significant differences in MDT and DE values of generic formulations vs. reference with both USP apparatuses were found (*P<0.05) hence, dissolution profiles of metronidazole generic formulations cannot be considered similar to the dissolution profile of the reference. After using some equations to explain the release performance of metronidazole, dissolution data were well adjusted to Peppas-Sahlin and logistic models when the flow-through cell was used.
Conclusion: The main problem found with the studied formulations was that generic drug products showed different dissolution performances than the reference, and they did not meet the biowaiver criteria for either class I or class III drugs; therefore, they cannot be considered therapeutic equivalents.
A NEW STABILITY INDICATING UPLC METHOD FOR THE DETERMINATION OF TWO ANTIDIABETIC DRUGS IN COMBINATION: APPLICATIONS TO BULK AND TABLET FORMULATION
Authors: PAWAR A. KRISHNAMANJARI , UNADE TAREKEGN TADESSE
Published: July 2022

Objective: This work was intended to develop a rapid and sensitive stability-indicating ultra-performance liquid chromatographic (UPLC) method for the determination of Metformin and Gliclazide simultaneously in their pharmaceutical bulk and tablet formulation.
Methods: Separation was performed on Lunna C18 (100 mm x 2.6 mm, 1.6µ) column by using trifluoroacetic acid buffer: acetonitrile (70: 30, v/v) as a mobile phase at a flow rate of 1 ml/min and a wavelength of detection of 227 nm. Method validation and forced degradation studies were conducted per the respective guidelines of the International Conference on Harmonization.
Results: Retention times under the optimized condition were 1.719 min and 2.845 min for Metformin and Gliclazide, respectively. Linearity ranged between 25.0-375.0 µg/ml for Metformin and 4.0-60.0 µg/ml for Gliclazide with a coefficient of determinations (r2) of greater than 0.99. The limit of detection values was 0.25 µg/ml for Metformin and 0.04 µg/ml for Gliclazide. Recovery results ranged from 99.63-101.23 %, and the % RSDs for the precision studies were less than 1.11% for both drugs. The % degradations at various stress conditions ranged from 14.0-5.0% for Metformin and 13.3-2.4% for Gliclazide. The analyte peaks were clearly resolved from the degradant peaks in forced degradation studies.
Conclusion: A fast, sensitive and efficient ultra-performance liquid chromatographic method was successfully developed and validated for the concurrent estimation of Metformin and Gliclazide in their combination, and thus the proposed method can be effectively applied for routine quality control works.
OVERVIEW OF PECTIN AS AN EXCIPIENT AND ITS USE IN THE PHARMACEUTICAL DOSAGE FORM
Authors: SOPYAN IYAN , GOZALI DOLIH , K. S. INSAN SUNAN , GUNTINA RIZKA KHOIRUNNISA
Published: July 2022

Pectin is a polysaccharide that is abundant in nature and has promising uses in the pharmaceutical field. Pectin is resistant to digestive enzymes but pectin gel can swell in aqueous media and small amounts of compounds can be released into the gastrointestinal tract. This problem can be solved by developing pectin composites obtained from the incorporation of pectin polymers with other polymers. This article discusses the interaction of pectin with other polymers in various drug delivery systems. The method used in review articles is to review nationally and internationally published scientific journals obtained from Google, Google Scholar, Pubmed and Science Direct. From several related studies, delivery systems that have been developed and reported in the form of films, hydrogels, particulate systems and tablets. Other polymers such as Alginatee, protein, chitosan, gelatin and starch are known to improve the properties of pectin so that pectin composites can be used as controlled drug delivery. Thus, the development of other drug delivery systems with pectin composites becomes an opportunity and challenge in the future.
Research on Densely-deployed Air Quality Monitoring
Authors: Kong In-Yeup
Published: July 2022

In this paper, the limitations of the existing air quality measurement system were identified, and factors and related cases were studied to overcome them. In the existing measurement system, it is difficult to properly understand the environment in which the user lives because the area to be covered by the measurement station is too large. In addition, since the reliable measurement method is used, the average of the previous hour's data is shared, so it is not possible to quickly grasp changes in air quality that change every minute. Based on the contents examined, it is expected that the elements to be configured so that users can receive and utilize close air quality information in real time at the location where they live is expected to be concrete.
Old Man Patrikeich: An Introduction to the Cultural Biography of a Hack Writer at the Turn of the 19th Century
Authors: Vinitsky Ilya Yu.
Published: July 2022

In this essay I establish the real addressee of Denis Fonvizin’s satirical epistle to the very bad poet Iamshchikov and reconstruct the literary legend of this colorful character, seen in the context of the cultural history of the image of the untalented poor writer who imposes his works upon wealthy and influential patrons. I introduce an unknown work of Timofei Patrikeevich Iamshchikov called “The permanent love of the Starling clock. A curious-serious drama,” which was first staged in St. Petersburg in 1796. At the turn of the 19th century quotes from this curious work were cited by contemporaries as examples of “the apotheosis of stupidity,” and the figure of the poetaster Patrikeich became a comic symbol of poetic ugliness. The text of the comedy gives us a unique opportunity to hear the voice of Iamshchikov himself, as he formulated his creative credo of the “little author,” mocked by representatives of the literary elite. The fact of the existence of the writer Patrikeich changes our perception of the social structure and dynamics of Russian literature at the turn of the nineteenth century, introducing the image of the poet-clown, of an inspired army versifier who brings his own simple word into the world.
“They Both had their own Pontius Pilate:” Leonid Dolgopolov and Miron Petrovsky Discussing on Bulgakov and Mayakovsky
Authors: Molodiakov Vassili E.
Published: July 2022

Russian Modernism scholar Leonid Konstantinovich Dolgolopov (1928–1995) in the late 1980s and early 1990s wrote several research articles on life and works of Vladimir Mayakovsky whom he considered one of the greatest Russian poets of the 20th century. Dolgopolov also highly appreciated works of Mikhail Bulgakov; he wrote no papers on him but closely watched other scholars’ research, especially during “Bulgakov’s boom” of the Perestroika years. Dolgopolov carefully read the article about Bulgakov vs. Mayakovsky confrontation by a literary critic and scholar Miron Semenovich Petrovsky (1932–2020) published in influential magazine “Literaturnoe obozreniye” (“Literary Review”) in 1987, June. Petrovsky sent him a copy inscribed “as a sign of agreement and disagreement.” Dolgopolov made detailed marginalia and wrote separated notes on this subject which are published here for the first time (originals in the present author’s collection). Dolgopolov criticised Petrovsky’s approach to the subject which was important to him and briefly outlined his own view. Dolgopolov was interested in the both Bulgakov and Mayakovsky not as much as participants of the literary process, belonging to different camps and polemicizing with each other, but as examples of a collision between the great artist and the political power. Tragic destiny of the Poet / Prophet endowed with a higher mission and dying while completing it was a major subject of Dolgopolov’s late research and literary work.
Vladimir Burnashev as an Anecdotist
Authors: Reitblat Abram I.
Published: July 2022

Being a journalist, author of many books for children, popular science essays and compilations, a newspaper day laborer, Vladimir P. Burnashev is especially interesting for literary historians as a memoirist who in the 1870s performed with the memoirs about contemporary writers and historical figures, mainly of the 1820s –1840s. The publication is devoted to the anecdotes collected from the literary and social life of Russia in the 19th century, which were recorded by Burnashev. It is an important and still unsufficiently studied aspect of his creative heritage. The article is accompanied by the publication of a selection of uncensored (mostly scandalous in their subjects) texts by Burnashev from the archives of the Pushkin House and the National Library of Russia. The article raises the question of the anecdotes genre specifics in the 19th century as well.
The Plan for a Soviet Academy in Rome (1924): Viacheslav Ivanov, Anatoly Lunacharsky, Petr Kogan and Others
Authors: Shishkin Andrei B.
Published: July 2022

In spring of 1924 Viacheslav Ivanov was invited to Moscow to participate in the June celebrations of the 125th anniversary of Aleksandr Pushkin’s birth. The months he spent in the capital reflect an unusually active social schedule. As his address book of the summer of 1924 indicates, he met with a wide range of people: composers and performers (Reinhold Glière, Mikhail Gnesin, Aleksandr Grechaninov, Aleksandr Goldenweiser, Nikolai Miaskovsky, Nikolai Medtner, Leonid Sabaneev), poets and prose writers (Valery Briusov, Iurgis Baltrushaitis, Andrei Globa, Vasily Kazin, Vladimir Lidin, Isaiah Lezhnev, Vladimir Nilender, Ivan Novikov, Sergei Poliakov, Ivan Rukavishnikov, Sergei Shervinsky, Anastasia Tsvetaeva), theater directors (Vsevolod Meyerhold, Aleksandr Tairov), literary scholars (Mikhail Gershenzon, Leonid Grossman, Viktor Zhirmunsky, Boris Eichenbaum), artists (Anatoly Arapov, Nikolai Ulianov, Nikolai Vysheslavtsev, Konstantin Yuon), priests and theologians (Sergei Sidorov, Pavel Florensky), art historians and museum curators (Count Valentin Zubov, Nikolai Mashkovtsev, Boris Ternovets, Abram Efros) and others. Many of these people were in one way or another connected to the activity of the State Academy for the Study of the Arts (GAKhN). It was in fact for GAKhN that Ivanov gave a series of well-received lectures. After receiving his passport to travel to Italy on 4 July 1924, Ivanov decided to postpone his departure for an entire month.

It would seem that this delay was connected to the need to draw up a project for the creation in Rome of a Soviet State Institute for History, Archeology and Art History. The project was supported by Petr Kogan, the president of GAKhN, and by Anatoly Lunacharsky, the head of the People’s Commissariat of Enlightenment. The Institute was envisioned as an organization that would serve both researchers and students, following the models of the corresponding academies in Rome — the French Academy, the French School of Archeology, the German Archeological Institute, etc. As Ivanov formulated it in the first plan that he gave to Lunacharsky on 24 August 1924: “The absence of Russia in the arena where cultured peoples are jointly and competitively pursuing scholarly work and cooperating in advanced scholarly colloquy is a kind of voluntary exclusion from contemporary civilization and an indirect affirmation of false rumors about the decline of our culture.”
Proporcionalidade entre grandezas na EJA: experiências no ensino remoto
Authors: Rodrigues Ribeiro Jéssica , Correia Ferreira Ana Rafaela
Published: July 2022

Esse texto apresenta o relato de ações desenvolvidas em três aulas de Matemática com foco na proporcionalidade entre grandezas e regra de três, por uma professora em formação inicial, sob orientação, junto a uma turma dos anos finais do Ensino Fundamental, na modalidade Educação de Pessoas Jovens e Adultas (EJA). Nosso propósito é o desenvolvimento do pensamento algébrico em aulas de Matemática síncronas, desenvolvidas em um ambiente remoto de ensino, devido à pandemia de COVID-19 e a suspensão das aulas presenciais. Temos como foco analítico os saberes dos estudantes jovens e adultos e seus argumentos e exemplos, no que tange à sua vida cotidiana. Tivemos como estratégia pedagógica central a resolução de problemas. Os principais resultados encontrados apontam a importância de se desenvolver um trabalho com Álgebra mais significativo, que leve em conta os saberes dos educandos e suas formas de pensar ao resolver os problemas. Outro ponto importante é a necessidade de que professores em formação inicial vivenciem na prática experiências na docência, de modo a contribuir para o seu fazer pedagógico.
Ferramentas didáticas de Geometria no Ensino Fundamental I
Authors: Silva Pedro Henrique da Conceição , E Silva Roberta Araújo , De Sá Aleandra Ribeiro , Dos Santos Dione Cléia Pereira
Published: July 2022

Há muito tempo o ensino de Geometria é colocado em segundo plano e, muitas vezes, nem é ensinado, ainda mais agora perante a pandemia. A forma de ensinar Geometria pouco é discutida. Usar metodologias ativas para se mudar o ensino de Geometria vem sendo a maneira de resgatar a disciplina que deveria ser estudada mais amplamente. O objetivo deste trabalho foi mostrar novas formas de se ensinar Geometria, buscando usar metodologias que pouco são lembradas e usadas, tais como a tecnologia (R.e.C.) e o velho e sábio Tangram. A análise foi realizada em duas escolas municipais de Ensino Fundamental I (1º ao 5º ano), da cidade de Paraíso do Tocantins –TO, em uma turma de 4º ano, onde foi aplicada uma metodologia em cada escola. Identificou-se que, independente da forma como é ensinada, a Geometria desperta o interesse do aluno e também mostra que as metodologias ativas abrem ao aluno uma visão real para a disciplina.
Rare Fibrolipoma of Attached Gingiva: A Case Report and Review of the Literature
Authors: rezazadeh fahimeh , Jaafari Zohreh , Afshari Aylar , Tarjan Armaghan
Published: July 2022

Fibrolipoma is a variant of lipoma that is relatively uncommon in the
mouth tissues, especially the attached gingiva. It is diagnosed by
histopathologic and immunohistochemistry evaluation and treated by total
excision. A case of a patient with attached gingiva fibrolipoma, treated
by surgical excision under local anesthesia is reported.
ROTA ABLATION -- WHEN THERE IS NO OTHER OPTION. A COMPLEX CASE OF 86 YEARS OLD MALE WITH MULTIPLE COMORBIDS PRESENTING WITH STEMI
Authors: Sahar Tooba , khan asaad , Rehman Taha Abdul , Satti Danish Iltaf
Published: July 2022

The aim of this report is to explore the direct and long-term outcome in
a high risk patient who was treated with rotational atherectomy to
assist the placement of drug eluting stents in heavily calcified
lesions.
Efficacy and safety analysis of PARP inhibitors combined with drugs for primary and relapsed ovarian cancer: A meta-analysis of randomized controlled trials
Authors: Ye Wanlu , Wang Yue , Xiang Nan , Lu Yanming
Published: July 2022

Background: Poly ADP-ribose polymerase (PARP) inhibitors have emerged as
maintenance therapy for advanced ovarian cancer. However, due to the
development of drug resistance, combination of PARP inhibitors with
other chemotherapeutic agents has become a contemporary research
hotspot. Methods: We conducted a meta-analysis of phase II or III
randomized controlled trials to analyze the efficacy and safety of
combinations of PARP inhibitors with various chemotherapeutic agents on
the progression-free survival (PFS) and overall survival (OS) of
patients with ovarian cancer. Results: A total of eight trials that
contained the combination of PARP inhibitors and chemotherapeutic agents
were included. Combination of PARP inhibitors with bevacizumab benefited
patients with BRCA mutations and HRD-positive status(HR=0.34 (95% Cl:
0.23–0.5; P<0.05); HR=0.35 (95% Cl: 0.27–0.45;
P<0.05)), while combination with chemotherapy prolonged the
PFS in the BRCA mutation, HRD, and homologous recombination proficiency
subgroups(HR=0.39 (95% Cl: 0.26–0.58; P<0.05);HR=0.57 (95%
Cl: 0.43–0.76; P<0.05); HR=0.79 (95% Cl: 0.64–0.98;
P<0.05) ). However, patients with BRCA wild-type or unknown
type benefited most from combination with cediranib. PARP inhibitors
increased the risk of G≥3 neutropenia when combined with
bevacizumab(RR=2.25, 95% Cl 1.09–4.62; P<0.05) and G≥3
anemia(RR=1.54, 95% Cl 1.16–2.05; P<0.05) and
neutropenia(RR=1.25,95% CL 1.00-1.57; P<0.05) when combined
with chemotherapy. Conclusion: Combination regimens of PARP inhibitors
showed benefits in both primary and recurrent ovarian cancer, and the
population subsets benefiting varied among different combinations. G≥3
adverse reactions were mainly hematological toxicities.
Plant roots fuel tropical soil animal communities
Authors: Zhou Zheng , Lu Jing-Zhong , Preiser Jooris , Scheu Stefan , Widyastuti Rahayu , Potapov Anton
Published: July 2022

Belowground life is traditionally considered to rely on leaf litter as
the main basal resource, whereas the importance of roots remains little
understood, especially in the tropics. Here, we analysed the response of
30 soil animal groups to root trenching and litter removal in rainforest
and plantations in Sumatra and found that roots are similarly important
to soil fauna as litter. Trenching effects were stronger in soil than in
litter with animal abundance being overall decreased by 42% in
rainforest and by 30% in plantations. Litter removal little affected
animals in soil, but decreased the total abundance by 60% both in
rainforest and rubber plantations but not in oil palm plantations.
Litter and root effects were explained either by the body size or
vertical distribution of specific animal groups. Our findings highlight
the importance of root-derived resources for soil animals and quantify
principle carbon pathways in tropical soil food webs.
Epidemiological and clinical features of SARS-CoV-2 Infection in children during the outbreak of Omicron Variant in Shanghai, March 7-March 31, 2022
Authors: Zeng Mei , Wang Xiangshi , Chang Hailing , Tian He , Zhu Yanfeng , Li Jingjing , Wei Zhongqiu , Wang Yixue , Xia Aimei , Ge Yanling , Liu Gongbao , Cai Jiehao , Zhai Xiaowen , Zhu Qirong
Published: July 2022

Objectives: To understand the epidemiological and clinical
characteristics of pediatric SARS-CoV-2 infection during the early stage
of Omicron variant outbreak in Shanghai. Study designs: This study
included local COVID-19 cases<18 years in Shanghai referred to
the exclusively designated hospital by the end of March 2022 since
emergence of Omicron epidemic. Clinical data, epidemiological exposure
and COVID-19 vaccination status were collected. Relative risks (RR) were
calculated to assess the effect of vaccination on symptomatic infection
and febrile disease. Results: A total of 376 pediatric cases of COVID-19
(median age:6.0±4.2 years) were referred to the designated hospital
during the period of March 7-31, including 257 (68.4%) symptomatic
cases and 119 (31.6%) asymptomatic cases. Of the 307 (81.6%) children
≥3 years eligible for COVID-19 vaccination, 110 (40.4%) received 2-dose
vaccines and 16 (4.0%) received 1-dose vaccine. The median interval
between 2-dose vaccination and infection was 3.5 (IQR: 3, 4.5) months
(16 days-7 months). Two-dose COVID-19 vaccination reduced the risks of
symptomatic infection and febrile disease by 35%(RR 0.65, 95% CI:
0.53-0.79) and 33% (RR 0.64, 95% CI: 0.51-0.81). Two hundred and
sixteen (83.4%) symptomatic cases had fever (mean duration:1.7±1.0.8
days), 104 (40.2%) had cough, 16.4% had transient leukopenia; 307
(81.6%) had an epidemiological exposure in household (69.1%) , school
(21.8%) and residential area (8.8%). Conclusion: The surge of
pediatric COVID-19 cases and multiple transmission model reflect wide
dissemination of Omicron variant in the community. Asymptomatic
infection is common among Omicron-infected children. COVID-19
vaccination can offer some protection against symptomatic infection and
febrile dise
Genomic Features of Transposase and Randomly Derived Recombinant CHO Clones
Authors: Huhn Steven , Chang Meiping , Jiang B. , Tang Xiaoyan , Betenbaugh Michael , Du Zhimei
Published: July 2022

The use of transposase in cell line development (CLD) programs has
experienced increased popularity over the past decade. However, few
studies have described the mechanism of action and the genomic and
phenotypic characteristics of clones derived from transposase.
Additionally, how these traits impact long-term bioproduction is
unknown. Here, we use chromosome painting, deep sequencing, and ddPCR to
characterize the unique fingerprints associated with transposase-derived
clones. Transposase reduces the cellular pool of transient vector as
early as three days post transfection following transfection and
expedites stable pool establishment by up to two weeks. Furthermore, ,
recombinant DNA expression is significantly improved up to
~3 fold along with a greater balance of antibody heavy
and light chain transcripts, resulting in higher titers in transposase
generated pools. Transposase derived pools contained an often
innumerable number of integration sites, representing a vast increase in
integration site diversity over randomly generated pools, which were
bottlenecked at 1-3 integration sites per pool. These transposase
mediated integrations typically occurred in clean singlets, free of
genomic scars such as deletions, inversions, and other modifications
associated with legacy transfection methods which exhibited higher copy
numbers per integration site. Also we observed a relative decline in
gene expression with copy number increase in the randomly generated, but
not the transposase derived clones. Furthermore, transposase-derived
clones were more likely to exhibit enhanced a long term stability
profile, including product quality attributes such as Mannose-5. This
improved stability may result from circumventing mechanisms associated
with the silencing of tandem repeats. Thus, transposase-mediated
approaches can provide multifaceted molecular and phenotypic advantages
in cell line development when compared to legacy random-integration
methods.