bluuebunny/crossref_metadata_2025 huggingface dataset:
Outcome analysis of low pressure versus high pressure pneumoperitoneum laparoscopic cholecystectomy: a randomized clinical study
Authors: Mahajan Salil , Shankar Manu , Garg Vinod K. , Gupta Vijender , Sorout Jaya
Published: October 2017

Background: Laparoscopic cholecystectomy is established as gold standard for management of cholelithiasis. Intraoperative pneumoperitoneum affects the postoperative outcomes. The current stress is on increasing patient safety. Hence, this prospective study was undertaken to compare the effect of low pressure pneumoperitoneum (LPP <10 mm Hg) versus high pressure pneumoperitoneum (HPP > 14 mm Hg) on postoperative pain and ileus.Methods: 120 patients undergoing laparoscopic cholecystectomy were randomized into the LPP (<10mm Hg) group (n=60) and the HPP (>14 mm Hg) group (n=60). Total duration of surgery, intra-operative gas consumption, occurrence of bile spillage during operation, shoulder pain and abdominal pain in postoperative period, additional requirement of analgesia in postoperative period and postoperative ileus were assessed.Results: There was no significant difference in terms of operative duration, consumption of CO2 gas, intraoperative bile spillage, total hospital stay and tolerance to early feeding. The incidence of shoulder pain was higher in patients who underwent HPP laparoscopic cholecystectomy (p<0.05). There was early recovery and early return of bowel activity in LPP which was statistically significant.Conclusions: Low-pressure pneumoperitoneum is feasible and safe and results in reduced postoperative shoulder tip pain and near-equal operative time with early return of bowel activity compared with high-pressure pneumoperitoneum.
Surgically benign recovery and histopathologically malignant transformation of a gliomatosis cerebri after radiotherapy: natural course or an unpredictable desired effect?
Authors: Dogan Ihsan , Erdem Atilla , Al-Beyati Eyyub S. M. , Ozgural Onur
Published: October 2017

Gliomatosis cerebri is a rare primary glial neoplasm of the central nervous system characterized by excessive involvement of the brain tissue. Dispersion and infiltrative growth pattern of this insidious pathology limit the utility of total surgical removal and are underlying causes of its poor prognosis. Furthermore, unresponsiveness of gliomatosis cerebri to radiotherapy and its classification as high grade or type 2 is reportedly associated with poor long-term survival. Contrary to our current knowledge, we report the case of a 54-year-old male who was diagnosed with gliomatosis cerebri. He presented with an exceptional clinical and pathological course and poor prognostic factors but was successfully treated with total surgical resection after radiotherapy. The present case findings indicate the potential utility of surgery, usually underestimated, as a curative treatment for gliomatosis cerebri. Clinicians should be aware of negative predictive factors that may help identify a small subset of patients suitable for total surgical tumor removal, as in the present case.
A case of mucinous cystadenoma of appendix
Authors: C. Tharun Ganapathy , Chandrasekar Shruthi , S. Jeyakumar
Published: October 2017

Mucocoele of the appendix is the term used to describe an appendix dilated with mucous collections due to benign or malignant causes. Primary tumors of the appendix are rare. Many a time, a mucocoele of the appendix is reported through histopathological study of the appendix removed in a scenario of acute appendicitis. 25% of the patients with mucocoele of appendix are asymptomatic, however patients may present with acute appendicitis or other obstructive symptoms. Here we report an unusual presentation of mucocoele of appendix who presented with chronic pain and mass in the right lower abdomen.
Successful embolectomy of bilateral femoral artery thrombosis in neonate
Authors: Gautam Bishal , Mathur R. M. , Devgarha Sanjeev , Sisodiya Anula
Published: October 2017

In childhood, the incidence of thrombotic disease, both spontaneous and catheter-induced, is highest in the neonatal period. Depending on the thrombus location, degree of aortic occlusion and involvement of other organs, aortic thrombosis clinical signs range from a completely asymptomatic presentation to a life threatening neonatal emergency. We report a case of aortoiliac thrombosis in a 12 days old baby, who presented with complaints of bluish-black patches on right foot for 4 days. Lower limb CT (Computed Tomography) Angiography showed thrombus in abdominal aorta involving proximal part of right common iliac artery. The anticoagulant therapy was initiated and surgical embolectomy was performed with restoration of blood flow, but the patient developed gangrene of right foot during the follow up period.
Oral teratoma-the devil’s curse: a case report
Authors: Singhvi I. C. , Pawar Jayadatta G.
Published: October 2017

Teratomas are true neoplasms originating from pluripotent cells and are composed of tissues from all three germinal layers, usually benign in nature. The most common sites are the sacrococcyx, anterior mediastinum, testicle, ovary, or retroperitoneum. Teratomas of head and neck are exceedingly rare and only about 10% of teratomas are found in this area. Nasopharynx and cervical region are the most common sites. We describe a one-day old female neonate with a large oral teratoma originating from the tongue which was successfully treated with surgery.
Giant cell tumor of tendon sheath
Authors: Singh Abhishek , Yadav Nagendra , Dogra Bharat Bhushan , Singh Ashutosh
Published: October 2017

Giant Cell Tumor of Tendon Sheath (GCTTS) is the second most common benign tumour affecting hand after ganglion. The tumor generally affects individuals between the age of 30 and 50 years, and is found more often in women than men. The etiological factors responsible for GCTTS are unclear. Some authors consider it as an inflammatory process arising as a consequence of chronic antigenic stimulation. Local excision with or without radiotherapy is the treatment of choice. We recently encountered two cases of Giant cell tumor involving tendon sheath of ring finger in one case and thumb in another case. Both were managed surgically with good results. There has been no evidence of recurrence till date in the follow up varying from 3-6 months.
Gestão do Conhecimento aplicado aos desastres naturais: o caso da Defesa Civil
Authors: Soriano Érico , Hoffmann Wanda Machado Aparecida , Araujo Camila de
Published: October 2017

Os Órgãos de Proteção e Defesa Civil no Brasil possuem profissionais competentes para trabalhar na gestão dos riscos de desastres naturais no país, uma vez que atuam diretamente nas áreas de risco e com os grupos populacionais vulneráveis a estes processos. Neste sentido, o conhecimento tácito e explícito desses profissionais é de grande importância para a prevenção e, principalmente, para as operações realizadas no enfrentamento do desastre e de outros momentos de crise. Porém, esse conhecimento é muitas vezes perdido em função da fragilidade institucional da Defesa Civil, especialmente em seu nível local. Desta forma, buscou-se fazer uma relação teórica sobre a aplicabilidade dos conceitos da Gestão do Conhecimento nos Órgãos de Defesa Civil, de forma a gerar conhecimentos para a melhoria no atendimento às ações de desastres naturais.
Sensitizing Clostridium difficile Spores With Germinants on Skin and Environmental Surfaces Represents a New Strategy for Reducing Spores via Ambient Mechanisms
Authors: Nerandzic Michelle Marie , Donskey Curtis J.
Published: October 2017

Background: Clostridium difficile is a leading cause of healthcare-associated infections worldwide. Prevention of C. difficile transmission is challenging because spores are not killed by alcohol-based hand sanitizers or many commonly used disinfectants. One strategy to control spores is to induce germination, thereby rendering the spores more susceptible to benign disinfection measures and ambient stressors.Methods/Results: C. difficile spores germinated on skin after a single application of cholic acid-class bile salts and co-germinants; for 4 C. difficile strains, recovery of viable spores from skin was reduced by ~0.3 log10CFU to 2 log10CFU after 2 hours and ~1 log10CFU to >2.5 log 10CFU after 24 hours. The addition of taurocholic acid to 70% and 30% ethanol significantly enhanced reduction of viable spores on skin and on surfaces. Desiccation, and to a lesser extent the presence of oxygen, were identified as the stressors responsible for reductions of germinated spores on skin and surfaces. Additionally, germinated spores became susceptible to killing by pH 1.5 hydrochloric acid, suggesting that germinated spores that remain viable on skin and surfaces might be killed by gastric acid after ingestion. Antibiotic-treated mice did not become colonized after exposure to germinated spores, whereas 100% of mice became colonized after exposure to the same quantity of dormant spores.Conclusions: Germination could provide a new approach to reduce C. difficile spores on skin and in the environment and to render surviving spores less capable of causing infection. Our findings suggest that it may be feasible to develop alcohol-based hand sanitizers containing germinants that reduce spores on hands.
Supra R-homeomorphism in supra topological ordered spaces
Authors: El-Shafei M. E. , Abo-Elhamayel M. , Al-shami Tareq
Published: October 2017

In this work, The notions of supra R-open sets and and increasing (decreasing, balancing) sets are utilized to initiate some ordered maps namely, x- supra R-continuous, x-supra R-open, x-supra R-closed and x-supra R homeomorphism maps, for x ∈ {I,D,B}. The equivalent conditions for each concept are given and the relationships among them are illustrated with the help of examples. Decompositions of some types of these maps are presented and investigated.
PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE STAD PADA SUB MATERI KETELADANAN ROSULULLAH SAW PERIODE MEKAH
Authors: Rehaeni Oon
Published: October 2017

Penelitian ini bertujuan untuk Penelitian deskriptif tentang penerapan model pembelajaran kooperatif tipe STAD bertujuan untuk mendeskripsikan aktivitas siswa, aktivitas guru dalam mengelola pembelajaran, serta hasil belajar siswa. Penelitian ini dilakukan ke Kelas X SMK Negeri I Majalengka dengan tindakan yang dilakukan sebanyak 3 siklus. Model penelitian yang dipilih adalah PTK kolaboratif, dengan melibatkan 2 observer sejawat guru Pendidikan Agama Islam. Instrumen yang digunakan adalah Lembar observasi aktivitas siswa, lembar observasi aktivitas guru dan Lembar ter akhir pada akhir siklus. Kesimpulan yang diperoleh dari penelitian ini adalah, bahwa pembelajaran dengan menerapkan metode pembelajaran kooperatif tipe STAD dapat meningkatkan aktivitas siswa yakni termasuk kategori baik, memperbaiki pola pengajaran guru termasuk kategori baik, serta dapat meningkatkan hasil belajar siswa dengan ketuntasan sesuai dengan kurikulum.
PENGARUH PENGGUNAAN MEDIA CD INTERAKTIF PENATAAN TAMAN TERHADAP HASILBELAJAR MAHASISWA PROGRAM STUDI PENDIDIKAN KESEJAHTERAAN KELUARGA UNIVERSITAS NEGERI JAKARTA
Authors: Mashabi Nurlaila Abdullah , Rusilanti Rusilanti , Khasanah Imawaty Nur
Published: October 2017

Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan media CD interaktif terhadap hasil belajar mahasiswa program studi Pendidikan Kesejahteraan Keluarga (PKK) Universitas Negeri Jakarta. Sampel pada penelitian ini berjumlah 40 mahasiswa yang tersebar secara merata pada kelas kontrol dan kelas eksperimen. Metode yang digunakan pada penelitian ini adalah quasi eksperimen dengan desain penelitian nonequivalent control group design. Instrumen penelitian yang digunakan pada penelitian ini adalah jenis tes objektif pilihan ganda. Teknik analisa data yang digunakan pada penelitian ini menggunakan uji t (independent sample t-tes). Sebelum dilakukan pengujian analisis, terlebih dahulu dilakukan uji prasyarat analisis yakni dengan uji normalitas dan uji homogenitas. Hasil pengujian hipotesis menggunakan uji t dengan taraf signifikansi 0,05. Uji analisis dihitung dari hasil selisih skor posttest pretest kelas eksperimen dan kelas kontrol yang menghasilkan thitung lebih besar dari ttabel (thitung>ttabel) yaitu sebesar 2,865>2,093. Hal ini menunjukkan bahwa hipotesis nol (Ho) ditolak. Dari hasil tersebut dapat disimpulkan bahwa bahwa terdapat pengaruh penggunaan media CD interaktif penataan taman terhadap hasil belajar mahasiswa.
PENGARUH POLA ASUH ORANGTUA TERHADAP STABILITAS EMOSI REMAJA AKHIR
Authors: Tidarsari Adita Putri , Muhariati Metty , Tarma Tarma
Published: October 2017

Dalam perilaku kestabilan emosi remaja akhir banyak faktor yang dapat mempengaruhi. Salah satunya faktor pola asuh orangtua dimana pada saat perkembangan remaja orangtua harus menerapkan pola asuh yang tepat sesuai dengan kebutuhan remaja akhir. Penelitian ini bertujuan untuk mengetahui seberapa besar Pengaruh Pola Asuh Orangtua Terhadap Stabilitas Emosi Remaja Akhir. Metode ini menggunakan metode penelitian Kuantitatif. Teknik pengambilan sampel menggunakan Cluster Proportionate random sampling dengan jumlah sampel penelitian sebanyak 270 mahasiswa yang terdiri dari 9 Program Studi di Fakultas Teknik. Teknik pengumpulan data menggunakan kuesioner dengan skala Likert. uji linearitas diperoleh  sedangkan  maka dapat disimpulkan data populasi memilki persebaran data linear. Pengujian hipotesis yang dilakukan adalah  uji korelasi. Hasil dari uji korelasi diperoleh 0,530 dapat disimpulkan terdapat hubungan yang positif antara variabel X dan Y Berdasarkan hasil pengujian kofisein determinan diperoleh hasil sebesar 28,04% hal ini menunjukan bahwa variabel  pola asuh orangtua memberikan sumbangan pengaruh terhadap stabilitas emosi
Análisis de los alimentos publicitados entre la audiencia infantil en la televisión chilena
Authors: González-Hidalgo Catalina
Published: October 2017

Objetivo. Examinar la publicidad de alimentos dirigida a la audiencia infantil en la televisión chilena. Material y métodos. Estudio de diseño transversal. Se registró la publicidad de alimentos emitida por cuatro canales de televisión de señal abierta, durante 12 horas diarias, en 12 días seleccionados aleatoriamente. Los avisos se clasificaron según grupos de alimentos y nivel de procesamiento. Se comparó la frecuencia de avisos de alimentos dirigidos a la audiencia infantil con los destinados a adultos. Se describió el perfil de nutrientes de los alimentos publicitados. Resultados. En 144 horas de grabación aparecieron 530 avisos de alimentos; 53.2% estaban dirigidos a la audiencia infantil. Los alimentos más publicitados entre los niños fueron lácteos azucarados (28.4%), bebidas azucaradas (25.5%) y cereales azucarados (17.7%). De dichos alimentos, 75% supera el criterio para azúcares libres. Conclusiones. En la televisión chilena se publicitan alimentos ultraprocesados que superan los límites de azúcares libres.
Cambios en los patrones de gasto en alimentos y bebidas de hogares mexicanos (1984-2014)
Authors: Garza-Montoya Beatriz Gabriela , Ramos-Tovar María Elena
Published: October 2017

Objetivo. Analizar la proporción del gasto y de su frecuencia en alimentos y bebidas consumidos dentro y fuera del hogar, en los ámbitos nacional y regional en México entre 1984 y 2014. Material y métodos. Se analizaron datos de la Encuesta Nacional de Ingresos y Gastos de los Hogares (ENIGH) 1984, 1994, 2005 y 2014 sobre el gasto monetario de los hogares en alimentos y bebidas. Se utilizaron estadísticas descriptivas tales como porcentajes, tasas de crecimiento y tablas de contingencia. Resultados. Se encontraron cambios en patrones del gasto alimentario a nivel nacional y regional. Aumentó la proporción del gasto y de su frecuencia en bebidas no alcohólicas, alimentos preparados, comidas fue­ra de casa y cereales. Disminuyó la proporción del gasto y de su frecuencia en aceites y grasas, frutas, vegetales y azúcares y mieles. Conclusiones. Los cambios detectados pueden estar relacionados con transformaciones políticas, económi­cas, sociales y culturales manifestadas en las últimas décadas.
Comprendiendo los factores que determinan la distorsión perceptiva de la imagen corporal en adolescentes
Authors: Ramos-Vidal Ignacio
Published: October 2017

Señor editor: Hago llegar avances preliminares de una investigación diseñada para profundizar en los efectos que producen las relaciones sociales y la satisfacción con el entorno relacional en el desarrollo de distorsiones perceptivas de la imagen corporal, en población adolescente de sexo femenino...
Influenza en el Estado de México: de la pandemia a la endemia
Authors: Coria-Lorenzo José De Jesús , Ortíz-García Enrique Rafael , Mirón-Calderón Xochitl , Dávila-Chávez Elizabeth , Pla-Esquivel Evelyn , Reséndiz-Tinajero Héctor Hail , Nava-Ruiz Alfredo , Martínez-Marroquín Martha Yolanda
Published: October 2017

Señor editor: Con el objetivo de tomar ciertas decisiones en cuanto a políticas locales de prevención de influenza, tomando como base la pandemia de 2009,1,2 y considerando cuestionamientos como cuál ha sido el comportamiento de la influenza desde la pandemia y si ha prevalecido AH1N1-PDM09, ponemos a su consideración el análisis epidemiológico de la morbilidad asociada con los casos corroborados de los diferentes tipos de influenza en cada temporada, a partir de la pandemia a la fecha en el Estado de México, enfocados principalmente en la vigilancia de la influenza pandémica, tal y como se ha hecho en otras partes desde la pandemia española de 1918...
Factores de riesgo cardiovascular en pacientes con diabetes mellitus tipo 2 atendidos en consulta externa
Authors: Garza-López Elisa Paola , Silva-Ruiz Rosendo , Rodríguez-Pérez Carlos Vicente
Published: October 2017

Señor editor: La diabetes mellitus tipo 2 (DM2) tiene una prevalencia muy alta en muchos países, incluyendo México, país que se encuentra dentro de los primeros diez lugares, donde esta enfermedad es la primera causa de mortalidad...
Asociación entre índices antropométricos de salud y condición física en mujeres mayores físicamente activas
Authors: Valdés-Badilla Pablo , Godoy-Cumillaf Andrés , Ortega-Spuler Jenny , Herrera-Valenzuela Tomás , Durán-Agüero Samuel , Zapata-Bastias José , Vargas-Vitoria Rodrigo , Guzmán-Muñoz Eduardo , López-Fuenzalida Antonio
Published: October 2017

Objetivo. Asociar los índices antropométricos de salud con la condición física de las mujeres mayores (MM) que participan en talleres de ejercicio físico. Material y métodos. Participaron 272 mujeres chilenas mayores de 60 años. Las variables correspondieron al IMC, perímetro de cintura (PC), índice cintura estatura (ICE) y condición física (CF). Se realizaron correlaciones a través del coeficiente de Pearson o Spearman, y asociaciones bivariadas mediante ji cuadrada de Pearson y el test exacto de Fisher, considerando un p<0.05. Resultados. De las MM, 70.8% alcanzó sobrepeso u obesidad; y 68.8% y 96% riesgo cardiometabólico de acuerdo con PC e ICE, respectivamente. Su CF presentó un rendimiento igual (53.5%) o superior (33.8%) según su edad y sexo. Se encontraron correlaciones inversas entre estado nutricional y riesgo cardiometabólico con las pruebas de CF (excepto la agilidad y equilibrio dinámico, en donde la relación fue directa), y asociación directa con juntar manos. Conclusiones. El exceso de peso en MM físicamente activas no afecta su rendimiento físico-funcional; sin embargo, el riesgo cardiometabólico se asocia inversamente con la funcionalidad motriz.
Mieles de abejas sin aguijón en el tratamiento de úlceras de pie diabético
Authors: Grajales-Conesa Julieta , Ibarias-Toledo Citlalli , Ruíz-Toledo Jovani , Sánchez Daniel
Published: October 2017

Señor editor: La formación de úlceras infecciosas en miembros inferiores de pacientes diabéticos es un motivo de consulta cada vez más frecuente. Debido a la neuropatía y al costo del tratamiento, es común observar úlceras en estados infecciosos avanzados que son imposibles de sanar. En diversos hospitales de países desarrollados se emplean alternativas más económicas para el cuidado profesional de heridas, como la miel de Manuka, producida por Apis mellifera...
Eventos potencialmente traumáticos y sintomatología postraumática en estudiantes de preparatoria
Authors: Mendoza-Mojica Sheila Adriana , Márquez-Mendoza Octavio , Veytia-López Marcela , Ramos-Lira Luciana Esther , Orozco-Zavala Ricardo
Published: October 2017

Objetivo. Describir la ocurrencia de eventos potencialmente traumáticos (EPT) en estudiantes de preparatoria, medir la sintomatología postraumática subumbral en quienes aún sufren repercusiones de un EPT y asociar la sintomatología con variables sociodemográficas y características del EPT. Material y métodos. Estudio transversal analítico realizado en un muestra por conveniencia de 1 000 estudiantes de tres preparatorias del Estado de México. Se aplicó la Escalapara Estrés Postraumático en Universitarios Mexicanos. Se evaluó la presencia de síntomas y su frecuencia; la asociación con variables explicativas se realizó con modelos de regresión logística y cuantílica, respectivamente. Resultados. 80% reportó un EPT. De éstos, 79% aún sufría repercusiones actuales y casi la mitad de ellos presentó sintomatología. El sexo, número de eventos y características del EPT (cambios percibidos y gravedad) se encontraron asociados. Conclusiones. Los resultados sugieren intervenir tempranamente para disminuir el riesgo de desarrollar un trastorno.
Perfil de resistencia de uropatógenos en pacientes con diabetes en Quito, Ecuador, inquietante panorama
Authors: Gordillo-Altamirano Fernando , Barrera-Guarderas Francisco
Published: October 2017

Señor Editor: Las infecciones del tracto urinario (ITU) se encuentran entre las infecciones bacterianas más comunes y los pacientes con diabetes tienen mayor riesgo de sufrirlas. Aunque el espectro de agentes etiológicos es reducido y predecible, los mecanismos y tasas de resistencia a antimicrobianos han aumentado, lo que dificulta el tratamiento empírico.
Fractured–Injection–Well Performance Under Non–Newtonian, Power–Law Fluids
Authors: Raghavan R.. , Chen C..
Published: October 2017

A new source function developed in this work is used to predict well responses to evaluate long-term injectivity and late-time responses of fractured wells after the injection of a non-Newtonian, pseudoplastic fluid. The source function yields integrals of modified Bessel functions of fractional order that are evaluated numerically by techniques developed by the authors. Consideration of well responses after the injection of pseudoplastic fluids into reservoirs through fractured wells requires the solution of a nonlinear differential equation and examination of flow fields in two dimensions. Consequently, numerical methods have been the only recourse. This work explores the applicability of new tools developed in recent times by analytical means. Calculating well injectivity accurately and rapidly for this complex situation by the methods outlined here is particularly convenient. The expressions we derive may be readily applied to concepts such as the Peaceman (1978) probe radius and transient well injectivity. Predictions by use of the new solution are compared with numerical solutions in the literature.
First Implementation of Diversion Stimulation Service with Multimodal Particles in Caspian Offshore Oilfield
Authors: Golenkin M. Y. , Khaliullov I. R. , Byakov A. P. , Charushin A. B. , Burdin K. V. , Vereschagin S. A. , Olennikova O. V. , Borisenko A. A. , Lobov M. A. , Kobets V.
Published: October 2017

In 2016, the first application in Russia of a diversion technology with multimodal granules was performed during matrix treatment of a carbonate reservoir in a water-absorbing well in an offshore field in the northern Caspian Sea.

The operator's main objectives were the recovery of water-absorbing well injectivity while simultaneously straightening the profile by a temporary isolation of high-absorbing intervals. To achieve the objectives, two operations needed to be performed: large-volume acidizing of J3V Volgian regional stage and acid spotting in the interval of the Neocomian superstage.
SILAGEM DE CANA-DE-AÇÚCAR TRATADA COM INOCULANTES MICROBIANOS E SUAS MISTURAS
Authors: Moraes Rodrigo Lopes , Ribeiro Karina Guimarães , Pereira Odilon Gomes , Marcondes Marcos Inácio , Cardoso Lucas Ladeira
Published: October 2017

Objetivou-se avaliar a composição química, o perfil fermentativo, a população de micro-organismo e a recuperação de matéria seca de silagens de cana-de-açúcar tratada com diferentes misturas de inoculantes microbianos. O experimento foi conduzido no delineamento inteiramente casualizado, com seis tratamentos e três repetições. Os tratamentos consistiram de silagem de cana-de-açúcar (SC) (controle); SC + Lactobacillus buchneri; SC + Propionibacterium acidipropionici; SC + P. acidipropionici + Lactobacillus plantarum; SC + L. buchneri + P. acidipropionici; SC + L. buchneri + P. acidipropionici + L. plantarum. A forragem foi picada e ensilada em baldes com capacidade de 20 L, providos com válvulas de “Bunsen”, os quais foram abertos 90 dias após o fechamento. Os inoculantes microbianos e suas misturas não proporcionam resultados promissores sobre a composição química, o perfil fermentativo, as populações microbianas e a recuperação de matéria seca da silagem de cana-de-açúcar. Mais alta produção de etanol ocorreu com a mistura de Lactobacillus buchneri + Propionibacterium acidipropionici e mais baixa recuperação de matéria seca ocorreu com as misturas P. acidipropionici + Lactobacillus plantarum e L. buchneri + P. acidipropionici + L. plantarum, em relação ao controle.
Plasma cell neoplasms in HIV-Infected Patients: A Literature Review and Case Series
Authors: Leigton R.A. , Pivnik Aleksandr Vasil'evich , Sergeeva E.P. , Kremneva N.V. , Mukhin O.V.
Published: October 2017

Aim. Analysis of 37 published and 2 author's cases of multiple myeloma (MM) in HIV-positive patients. Materials & Methods. Description of 37 patients and 2 author's previously unpublished observations. Results. The median age of patients was 37 years (66 in the general population), only 2 % being under 40 years. Abnormal MM progression was observed including the emergence of extramedullary lesions, low levels of M-gradient, and the development of plasmoblastic leukemia. Historically, before highly active antiretroviral therapy (HAART) was introduced, a rapid progression of MM with a short life expectancy was observed. HAART in combination with chemotherapy showed the best results of MM treatment in terms of overall and relapse-free survival. According to the literature data HAART may also be used to treat HIV-negative patients with MM. The cytological analysis of MM showed atypical myeloma cells with no lysozyme, leukocyte common antigen, CD19, and CD20. The CD38 was clearly identified. Anaplastic MM may be regarded as the first manifestation of AIDS. The author's results were similar to the published data. Conclusion. MM in HIV-infected patients in stage with secondary diseases is still considered to be not HIV-related. In HIV-positive MM patients on HAART overall and relapse-free survival rates were higher than that in HIV-negative patients with MM. The serum levels M-gradient was shown to decrease or even become indeterminate in MM patients receiving HAART for HIV infection. Thus, the HAART was proposed for MM HIV-negative patients.
Pathogenetic Characteristics of Anemia in Patients with Solid Tumors
Authors: Sakhin Valery Timofeevich , Madzhanova E.R. , Kryukov E.V. , Sotnikov A.V. , Gordienko A.V. , Rukavitsyn O.A.
Published: October 2017

Aim. To study the impact iron metabolism disturbances and cytokine levels on the development of anemia in patients with solid tumors. Materials & Methods. The research included 42 patients with malignant neoplasms, including 24 patients with anemia (19 men and 5 women, median age 67.7 ± 10 years) and 18 patients without anemia (15 men, 3 women, median age 65.7 ± 14 years). Anemia was diagnosed according to the WHO criteria (in men: erythrocytes < 4.0 x 1012/L, hemoglobin < 130 g/L, hematocrit < 39 %; in women: erythrocytes < 3.8 x 1012/L, hemoglobin < 120 g/L, hematocrit < 36 %). Results. A comparative analysis of iron metabolism in patients with and without anemia was performed. The lower values of serum iron and transferrin saturation in patients with anemia were shown (p < 0.05). The total iron-binding capacity, the levels of ferritin, transferrin, C-reactive protein, indirect bilirubin were similar between groups (p > 0,05). Higher levels of interleukins 6 and 10 (IL-6 and IL-10) were observed in patients with anemia (p < 0.05). For IL-6, correlations were observed with levels of erythrocytes (r = -0,58), hemoglobin (r = -0,57), hematocrit (r = -0,52), and leukocytes (r = 0,42). The levels of IL-10 slightly correlated with the levels of erythrocytes, leukocytes, platelets, MCV, and MCH (r < 0.3). For IL-10, correlations were established with levels of MCHC (r = -0,71), hemoglobin (r = -0,64) and hematocrit (r = -0,32). Correlations between the levels IL-6, IL-6 and hemoglobin, erythrocytes and several color indices may indicate their influence on the development of anemia in patients with malignant neoplasms. Conclusion. A functional iron deficiency in patients with anemia was found. Several causes of anemia development and significant role of interleukins in anemia pathogenesis were also discovered.
Author’s reply to: Comments on “Asymptotically stable equilibrium points in new chaotic systems”
Authors: Casas-García K. , Quezada-Téllez L. A. , Carrillo-Moreno S. , Flores-Godoy J. J. , Fernández-Anaya Guillermo
Published: October 2017

Since theorem 1 of (Elhadj and Sprott, 2012) is incorrect, some of the systems found in the article (Casas-García et al. 2016) may have homoclinic or heteroclinic orbits and may seem chaos in the Shilnikov sense. However, the fundamental contribution of our paper was to find ten simple, three-dimensional dynamic systems with non-linear quadratic terms that have an asymptotically stable equilibrium point and are chaotic, which was achieved. These were obtained using the Monte Carlo method applied specifically for the search of these systems.
Simultaneous Assay of ρ-Coumaric Acid and Coumarin Co-encapsulated in Lipid-core Nanocapsules: Validation of an LC Analytical Method
Authors: Boschetti Ticiane Krapf , de Oliveira Edilene Gadelha , Rigo Lucas Almeida , Coradini Karine , Ruver Beck Ruy Carlos
Published: October 2017

Background:

Lipid-Core Nanocapsules (LNC) containing co-encapsulated-coumaric acid
and coumarin are under development. However, there is a lack of analytical methods to assay these
bioactives in nanoformulations.

Objective:

The aim of this study was to validate an LC analytical method for the simultaneous determination
of ρ-coumaric acid and coumarin in lipid-core nanocapsules.

Methods:

The mobile phase was composed of acetonitrile:water (40:60 v/v) adjusted to pH 4 and a C-
18 reversed-phase column was used. Both bioactives were detected at 275 nm. Specificity, linearity,
range, precision and accuracy of the method were assessed, according to the official requirements.

Results:

Nanocapsules containing ρ-coumaric and coumarin had monomodal particle size distribution,
spherical-shape and Z-average size of 207 ± 2 nm. LC method was specific, linear (5 to 30 µg.mL-1),
precise (RSD < 5%) and accurate (97 - 103%). It was applied to assay the content and encapsulation
efficiency of the bioactive substances in LNC, which were close to 0.5 mg.mL-1 and 72%, respectively.

Conclusion:

The proposed analytical method is reliable for the simultaneous assay of ρ-coumaric acid
and coumarin in nanocapsules and can be further used in their development.
A Simple, Green and Fast Ultraviolet Spectrophotometric Method for the Carbamide Peroxide Determination in Dental Whitening Products
Authors: Lima Fabiana Vieira , Farias Aline , Mendes Cassiana , Cardoso Simone Gonçalves , Segatto Silva Marcos Antônio
Published: October 2017

Background:

The carbamide peroxide is the most commonly active ingredient used for home
dental whitening products, its quantification in pharmaceutical products is of extreme importance due to
the relation with the products potency and the previously related low carbamide peroxide stability.
Once, there is only one official carbamide peroxide determination based on iodometric titration, this
method is time-consuming and generates a lot of residues. The aim of this study was to carry out development
and validation of a simple and fast ultraviolet spectrophotometer assay to quantify an innovative
dental whitening gel.

Methods:

The proposed method was validated according international conference on harmonization
guideline. Procedure is based on the iodide/iodine redox chemistry; iodine released through the action
of hydrogen peroxide of carbamide peroxide with ultraviolet detection at 350 nm.

Results:

The procedure was linear in the concentration range of 1.0-4.0 µg/mL, specific to the excipients,
robust for the evaluated parameters (variation of wavelength (± 5 nm); reagent addition (± 10%)),
showing the results of RSD 1.88 and 0.39% respectively. Repeatability precision was RSD = 1.42%,
with accurate RSD = 2.15% by adding reference solution. The assay used only water as solvent for
sample preparation. In comparison to the pharmacopeial method, the latter is more time-consuming, as
it generates a lot of residues, and it could not quantify small CP dosages.

Conclusion:

Thus, the proposed method was proved to be suitable to determine carbamide peroxide
during the development and characterization of nanoparticle formulations in the present study.
Possible Role of Phosphatidylglycerol-Activated Protein Kinase C-βII in Keratinocyte Differentiation
Authors: Bailey Lakiea J. , Choudhary Vivek , Bollag Wendy B.
Published: October 2017

Background:

The epidermis is a continuously regenerating tissue maintained by a balance between proliferation and differentiation, with imbalances resulting in skin disease. We have previously found that in mouse keratinocytes, the lipid-metabolizing enzyme phospholipase D2 (PLD2) is associated with the aquaglyceroporin, aquaporin 3 (AQP3), an efficient transporter of glycerol. Our results also show that the functional interaction of AQP3 and PLD2 results in increased levels of phosphatidylglycerol (PG) in response to an elevated extracellular calcium level, which triggers keratinocyte differentiation. Indeed, we showed that directly applying PG can promote keratinocyte differentiation.

Objective:

We hypothesized that the differentiative effects of this PLD2/AQP3/PG signaling cascade, in which AQP3 mediates the transport of glycerol into keratinocytes followed by its PLD2-catalyzed conversion to PG, are mediated by protein kinase CβII (PKCβII), which contains a PG-binding domain in its carboxy-terminus. Method: To test this hypothesis we used quantitative RT-PCR, western blotting and immunocytochemistry.

Results:

We first verified the presence of PKCβII mRNA and protein in mouse keratinocytes. Next, we found that autophosphorylated (activated) PKCβII was redistributed upon treatment of keratinocytes with PG. In the unstimulated state phosphoPKCβII was found in the cytosol and perinuclear area; treatment with PG resulted in enhanced phosphoPKCβII localization in the perinuclear area. PG also induced translocation of phosphoPKCβII to the plasma membrane. In addition, we observed that overexpression of PKCβII enhanced calcium- and PG-induced keratinocyte differentiation without affecting calcium-inhibited keratinocyte proliferation.

Conclusion:

These results suggest that the PG produced by the PLD2/AQP3 signaling module may function by activating PKCβII.
Evaluation of Effective Dashboards: Key Concepts and Criteria
Authors: Karami Mahtab , Langarizadeh Mostafa , Fatehi Mansoor
Published: October 2017

Objective:

The aim of this study is to offer appropriate criteria to evaluate effective dashboards for healthcare organizations.

Method:

In a Delphi study, a team of information technology consultants were asked to determine a set of user interface requirements for evaluating, building or selecting the dashboard. In the first round, a list of main features or criteria to be used was determined based on the panel’s rating,.

Results:

In this study, it was revealed that a set of key criteria for evaluating the dashboards can be used for all types of dashboards. These criteria were classified into 7 main categories including user customization, knowledge discovery, security, information delivery, alerting, visual design, and integration and system connectivity.

Conclusion:

Choosing good criteria for selecting effective dashboards for healthcare organizations is very critical because these organizations follow a data-intensive and technology-driven environment. This study revealed the importance of key criteria which can guarantee development of an evaluation checklist.
A Community Based Participatory Approach to Training Young Adults to Design and Implement a Social Marketing Framed Lifestyle Intervention on their College Campus (Preprint)
Authors: Olfert Melissa D. , Barr Makenzie L. , Riggsbee Kristin , Kattelmann Kendra K. , Leischner Krista , Mathews Anne E. , Vilaro Melissa , Colby Sarah E.
Published: October 2017

BACKGROUND

Using a Community-Based Participatory Research (CBPR) approach may increase the likelihood of relevance and acceptability of the designed intervention, especially on a college campus. Furthermore, recruiting and training college students to design and implement a social marketing framed healthy lifestyle intervention for their peers will allow the intervention to be tailored to the needs of the campus

OBJECTIVE

To describe the process of training college students to develop a campus-based, social marketing health promotion intervention

METHODS

Four universities recruited current college students (18+ y.o.) to develop a social marketing and environmental intervention (SMEI), which was completed during a 16-week semester course. Researchers and Extension professionals trained students to design 24 weeks of intervention events that would be implemented the upcoming year.

RESULTS

Seventy-eight students enrolled in the study and SMEI course among the four intervention states (FL=30, SD=8, TN=13, WV=27); students were predominately Caucasian (65.8%), females (84.0%), and sophomore status in college (64.9%). Throughout the semester, students assessed their campus environments, set priorities, and developed weekly events and resources needed to implement the intervention on their campuses. By the end of the semester, the students had designed 24 weeks of intervention events focusing on nutrition/food/diet, physical activity, stress management, sleep, and time management. SMEI students designed interactive events, advertisements, artwork, and social media posts for the intervention. These events and resources were catalogued into a digital toolkit of instructions and activities for each week of intervention events.

CONCLUSIONS

Training students to be social marketing and environmental interventionists via the CBPR process allows for the development of an intervention that stems from grass roots efforts and is tailored to the acceptability and needs of their peers.

CLINICALTRIAL

This study was prospectively registered in October 2016 on clinicaltrials.gov, NCT 02941497.
ANALYSIS OF THE INHIBITORY POTENTIAL OF CLINICAL STREPTOCOCCUS SALIVARIUS ISOLATES FROM SALIVA AND DORSAL OF TONGUE OF ADULTS ON ENTEROCOCCAL FAECALIS GROWTH
Authors: Ardywinoto Yohanes Bosko , Joenoes Hedijanti , Bachtiar Boy M
Published: October 2017

Objective: The aim of this study is to analyze the inhibitory potential of Streptococcus salivarius isolates from the saliva and dorsum of the tongue of adults on Enterococcal faecalis American Type Culture Collection (ATCC) 29212.Methods: Deferred antagonism and agar well diffusion methods were used to analyze the potential of S. salivarius to inhibit E. faecalis growth with S. salivarius ATCC 13419 as the positive control.Result: The maximum inhibitor diameter for each isolation was 11.17 mm at 1010 CFU for the dorsum of tongue isolates and 8.17 mm at 109 CFU for saliva isolates.Conclusions: Clinical S. salivarius isolates from the dorsum of tongue had greater potential for inhibiting E. faecalis growth compared to the saliva isolates and control bacteria.
ANALYSIS OF THE INHIBITION POTENTIAL OF STREPTOCOCCUS SALIVARIUS ISOLATED FROM THE SALIVA AND DORSUM OF THE TONGUE OF ADULTS ON THE GROWTH OF STREPTOCOCCUS MUTANS
Authors: Chintyanita Deborah , Joenoes Hedijanti , Bachtiar Boy M
Published: October 2017

Objective: The aim of this study is to analyze the inhibitory potential of Streptococcus salivarius, after it has been isolated from saliva and the tongue’sdorsum, on the growth of Streptococcus mutans.Method: Polymerase chain reaction, SDS PAGE, Bradford test, deferred antagonism test, and well-diffusion test were used.Result: S. salivarius isolated from saliva and the tongue’s dorsum inhibited the growth of S. mutans, but it was not the case with S. salivarius ATCC13419 (p<0.05). However, there was no significant difference between the inhibition of S. mutans from S. salivarius isolated from saliva and thetongue’s dorsum (p>0.05).Conclusion: S. salivarius isolated from saliva and the tongue’s dorsum can inhibit the growth of S. mutans, but there was no significant difference inthe inhibitory potential of S. salivarius isolated from saliva on the tongue’s dorsum.
EFFECTS OF PROPOLIS EXTRACT AND PROPOLIS CANDIES AGAINST CANDIDA ALBICANS ATCC 10231 GROWTH
Authors: Melinda Wida Priska , Soedarsono Nurtami , Farida Ratna
Published: October 2017

Objectives: This research was aimed at analyzing the effect of propolis extract and candies on Candida albicans growth.Methods: After C. albicans was exposed to propolis extract and candies, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined with spectrophotometry, and post-exposure colonies of C. albicans were counted.Results: The MIC of propolis extract against C. albicans was determined to be 10% and MBC to be 15%. Furthermore, C. albicans colonies were decreased after propolis extract and candies exposure.Conclusions: Propolis extract and candies were effective to inhibit C. albicans growth.
EFFECT OF PROPOLIS EXTRACT AND PROPOLIS CANDIES ON STREPTOCOCCUS SOBRINUS GROWTH
Authors: Faizah Hanny , Farida Ratna
Published: October 2017

Objectives: The objective of this study analyzes the effect of propolis extract and propolis candies on Streptococcus sobrinus growth.Methods: S. sobrinus was exposed to propolis extract and propolis candies. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined through spectrophotometric analysis and the S. sobrinus colonies were counted using the standard plate counted method.Result: MIC was 5% and MBC was 10%. S. sobrinus colonies decreased after exposure to propolis extract and propolis candies.Conclusions: Propolis extract and propolis candies could inhibit the growth of S. sobrinus.
THE EFFECT OF CURCUMA XANTHORRHIZA ETHANOL EXTRACT ON THE VIABILITY OF STREPTOCOCCUS MUTANS AND AGGREGATIBACTER ACTINOMYCETEMCOMITANS (DENTAL BIOFILM RESEARCH: IN VITRO STUDY)
Authors: Diana Royan , Joenoes Hedijanti , Djais Ariadna A
Published: October 2017

Objective: This study aimed to compare the effect of Curcuma xanthrorrhiza ethanol extract to the viability of Streptococcus mutans and Aggregatibacter  actinomycetemcomitans using single- and dual-species biofilm at different phases of formation.Methods: Biofilm models were incubated for 4, 12, and 24 hrs, then exposed to the extract at a concentration of 0.525%.Results: The viability of the single-species S. mutans biofilm was low (p<0.05), and no significant difference (p>0.05) was found between singlespeciesA. actinomycetemcomitans and dual-species biofilm.Conclusions: Curcuma xanthorrhiza ethanol extract is more effective for decreasing the viability of single-species S. mutans biofilm.
EFFECTIVENESS OF SHORT MESSAGE SERVICE REMINDERS AND LEAFLETS IN COMPLYING WITH IRON SUPPLEMENTATION IN PREGNANT WOMEN IN DEPOK CITY, INDONESIA
Authors: Anitasari Dina , Andrajati Retnosari
Published: October 2017

Objective: Lack of knowledge about iron supplementation among pregnant women contributes to poor compliance with the therapy. The use of media such as leaflets and short message service (SMS) reminders can be used to improve compliance. This study assessed the effectiveness of SMS reminders and leaflets in complying with iron supplementation in pregnant women. Methods: This quasi-experimental study used two intervention groups with a pre-test and post-test group design. This study was conducted from March to May 2016 in two public health centers in Depok City, Indonesia. A total of 38 respondents in Sukmajaya were given leaflets, and 36 respondents in Pancoran Mas received SMS reminders. Patients’ compliance was measured using the MMAS-8 questionnaire, and their hemoglobin levels were measured with HemoCue®. Results: A total of 19 respondents in the leaflet group experienced an increase in their hemoglobin levels (with an average of 0.6 g/dl). A total of 17 respondents in the SMS reminders group experienced an increase in hemoglobin levels (with an average of 1.1 g/dl). Conclusions: There was no difference between leaflets and SMS reminders in terms of improving patients’ compliance with iron supplement consumption or with increased hemoglobin levels (p=0.576 and p=0.929, respectively).
INFLUENCE OF PHARMACIST–DOCTOR COMMUNICATION ON PEDIATRIC ANTIBIOTIC PRESCRIPTIONS
Authors: Astuti Diany , Andrajati Retnosari , Supardi Sudibyo
Published: October 2017

Objectives: The purpose of the research was to describe drug-related issues and assess the effect of communication between pharmacists and physicians on decreased prescription drug-related problems in pediatric antibiotics.Methods: Intervention was carried out in the form of pharmacist discussing information-related issues about drugs with physicians prescribing antibiotics to pediatric patients. The research sample included 338 prescription sheets on pediatric outpatient use of antibiotics, and a prospective design was used. Analysis of the data was carried out in the form of a frequency distribution and bivariate analysis Wilcoxon test.Results: The results showed that drug-related problems were recorded on 62.22% of the 338 prescription sheets. The biggest problems that occurred had to do with the effectiveness of therapy (P1; 79.3%) and cost issues (P1; 20.7%). In terms of P1, drug-related problems involved excessive frequency of drug administration (80.1%), inappropriate drug dose selection (17.2%), drug interactions (9.6%), inadequate drug selection (12.2%), a subtherapeutic dose (4.1%), and excessive drug dose (0.5%). For P1, therapy cost problems were a lack of indication for the drug (84.1%) and improper drug selection (15.9%).Conclusions: The influence of pharmacist–physician communication concerning the reduction of drug-related problems for pediatric outpatient prescriptions was statistically significant (p<0.05). Ultimately, communication between pharmacists and physicians can reduce drug-related problems by 22.9%.