bluuebunny/crossref_metadata_2025 huggingface dataset:
The Influence of the Internal Environment on the Empowerment of MSMEs
Based on Environmental Management
Authors: Syntia R , . Badaruddin , Sadalia I , Budi Mulya M
Published: November 2018

.
The Creation of Entrepreneurship Class for Juvenile Resident: An
Entrepreneurial Behavior Review for Residents of Penitentiary Class II
Mojokerto
Authors: Wisnu Wardana L , Handayati P
Published: November 2018

.
Lecturer’s Performance: Leadership, Organizational Culture, Work
Motivation, and Work Behavior
Authors: Langgeng Ratnasari S , . Rahmawati , Sutjahjo G , Yana D
Published: November 2018

.
Service Quality of Banking Credit Based on Six-Sigma Method
Authors: Tejaningrum A
Published: November 2018

.
Factors Affecting Customer Switching Intentions in the Sharia Banking
Industry in Malang (A Conceptual Framework)
Authors: . Sunaryo
Published: November 2018

.
The Influence of Product Quality on Purchase Intention Through Electronic
Words of Mouth in PT. Telkomsel Medan
Authors: Septy Purba F D , Sulistyarini E , Sadalia I
Published: November 2018

.
Bond Market Development, Economic Growth, and the Role of Foreign
Investment
Authors: Muharam H , Ghozali I , Denny Arfinto E
Published: November 2018

.
Analysis of Human Development Index of 13 Districts in West
Kalimantan
Authors: Sulistianingsih E , Junian R , Wirarizki S
Published: November 2018

.
The Impact of the Implementation of Corporate Governance on the Financial
Performance of Non-finance Companies Registered in the Indonesian Stock
Exchange
Authors: Fitri Andriyani Muzakir M , Darmawan A
Published: November 2018

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Is Job Performance Affected By Job Motivation and Job
Satisfaction?
Authors: Eliyana A , Sawitri D , Bramantyo H
Published: November 2018

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Analysis of Impact of Consumer Emotional Aspects on Brand Loyalty in Gold
Installment Product
Authors: Lestari S , Fauzi A , Sadalia I
Published: November 2018

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The Effectiveness of Financial Accounting Information System with
Approach of Organizational Culture and User Competency in Baznas North of
West Java
Authors: . Nurhayati , Nurhayati N , Koesdiningsih N
Published: November 2018

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The Impacts of Carbon Emission Disclosure, Environmental Performance, and
Social Performance on Financial Performance (Empirical Studies in Proper
Participating Companies Listed in Indonesia Stocks Exchange, Year
2013–2016)
Authors: Soewarno N , Tjahjadi B , Hanifah Firdausi R
Published: November 2018

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Company Performance Predictions By Agency Cost, Earning Management Using
the Z-Score (Case Study in Indonesia)
Authors: Irawati N , Sadalia I , Marlina L
Published: November 2018

.
The Technology Acceptance Model for Playing Mobile Games in
Indonesia
Authors: Kaltum U , Rimadina R , Zusnita W
Published: November 2018

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The Problems of Women Education in Rimba Tribe and Solutions
Authors: Anwar K , Marmoah S
Published: November 2018

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The Effect of Current Ratio, Debt to Equity Ratio and Return on Asset on
Dividend Payout Ratio in Sub-sector Automotive and Component Listed in
Indonesia Stock Exchange in Period 2012–2016
Authors: Herawati A , Irradha Fauzia F
Published: November 2018

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Capital Strengthening of Micro-enterprises for Poverty Reduction in East
Java
Authors: Purmiyati A , Berma M , Abdul Talib B , Sabila Rakhima M
Published: November 2018

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Integration of Social and Economic Functions of Sharia Microfinance
Institutions in Empowerment of Micro-enterprises
Authors: Herianingrum S , Shofawati A , Ratnasari R T
Published: November 2018

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Supply Chain Quality Management Practice Model As an Enabler for
Operational Academic Process Toward Excellence Performance: An Explorative
Study
Authors: Usman I , . Windijarto , Putri R
Published: November 2018

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Disclosing Professionalism Behaviour of Internal Auditor in Preventing
Fraud By Using the Local Cultural Wisdom ‘Longko’ (A Case Study at Toraja
Tribe, South Sulawesi, Indonesia)
Authors: Paranoan N , Peleng Roreng P , Jeane Tandirerung C , Sadesto Tandungan E
Published: November 2018

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Factors Affecting Indonesian Consumers to Switch, Using Mobile Banking
and Internet Banking Service
Authors: Fahmi S , . Noermijati , Rohman F , . Sunaryo
Published: November 2018

.
Ownership Structure, Corporate Governance and Dividend Policy: Evidence
from Indonesia
Authors: Malavia Mardani R , . Moeljadi , . Sumiati , Khusniyah Indrawati N
Published: November 2018

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Corporate Governance and Disclosure Level in Mining Companies: Evidence
from Regulation Changes in Indonesia
Authors: Harymawan I , Nur Fadlillah R , Nasih M , Intan Paramitasari Y
Published: November 2018

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The Influence of Website Trust on Recommendation Adoption and
Word-of-Mouth Communication: Study on TripAdvisor Website
Authors: Alhabsyi S , Mardhiyah D
Published: November 2018

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Effect of Price, Products, Market Atmosphere and Trust on Rebuying
Interests Through Customer Satisfaction at Traditional Markets in
Surabaya
Authors: . Khuzaini
Published: November 2018

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Research on the Competitive Intelligence Alliance of Medical Devices
Based on Industrial-University-Hospital-Administration-Research
Authors: Kai-jun Y , Rui-yi G
Published: November 2018

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The Current Situation and Thinking of Ideological and Political Education
in College Students
Authors: Li R
Published: November 2018

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Research on the Application of Artistic Education Method in Ideological
and Political Work in Medical Colleges
Authors: Li R , Shi Q
Published: November 2018

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The Target Tracking Algorithm Based on Environment Technology
Authors: Shen Y
Published: November 2018

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The Exploration of the Cultural Contents of Pastry Totems and the Study
on Consumer Preference
Authors: Lee Y-J , Lee W-C
Published: November 2018

.
Overseas Communication and Acceptance of Hou Hsiao-Hsien’s
Films-Centering on Franch Cahiers Du Cinéma
Authors: Xiaohan T
Published: November 2018

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Computer Axial Flow Fan Optimization Design
Authors: Lin H-H , Cheng J-H
Published: November 2018

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Development of New Products by DEMATEL
Authors: Lin H-H , Huang Y-Y , Ko Y-C , Chen Y-T
Published: November 2018

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A Study of iPhone’s Attractiveness Factors By the Miryoku Engineering
Approach
Authors: Lo C-H , Liao G-Y , Tang Z-X , Chen X-W , Xu H-F , Hu J , . Linda
Published: November 2018

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A Study of the Application of Design By Metaphors to the User Interface
of Smartphones
Authors: Ko Y-C , Lo C-H , Chen C-C
Published: November 2018

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Exploration on Improving the Effectiveness of Quality Education for
Higher Vocational College Students under the New Situation
Authors: Cheng F , Hu L
Published: November 2018

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The Feeding Behavior of Costa Rican Velvet Worms: Food Hiding, Parental Feeding Investment and Ontogenetic Diet Shift (Onychophora: Peripatidae)
Authors: Barquero-González José Pablo , Vega-Hidalgo Álvaro , Monge-Nájera Julián
Published: November 2018

We report, for the first time in onychophorans, food hiding, parental feeding investment and an ontogenetic diet shift, from adhesive to prey, after their first two weeks of life.
PERPUSTAKAAN PERGURUAN TINGGI SEBAGAI PRIME MOVER PENINGKATAN KOMPETENSI LITERASI INFORMASI MAHASISWA
Authors: Handari Budi
Published: November 2018

Pesatnya perkembangan teknologi informasi mempengaruhi semua aspek kehidupan, termasuk pendidikan. Di bidang Pendidikan Tinggi, kompetensi literasi informasi memainkan peran penting dalam keseluruhan pendidikan mahasiswa.

       Salah satu misi perpustakaan perguruan tinggi adalah meningkatkan literasi informasi pengguna. Karena itu perpustakaan perguruan tinggi harus mampu berfungsi sebagai prime mover peningkatan kompetensi literasi mahasiswa.

       Literasi informasi berhubungan erat dengan tugas pokok pelayanan perpustakaan. Peningkatan kompetensi literasi informasi merupakan upaya pemberdayaan mahasiswa di bidang informasi, di antaranya melalui pendidikan pengguna.

       Dampak lain dari perkembangan teknologi informasi adalah meningkatnya permintaan informasi digital. Pencari informasi tidak lagi puas hanya dengan materi cetak. Untuk memenuhi tuntutan tersebut, pembangunan dan pendayagunaan perpustakaan digital sangat mendukung terlaksananya fungsi perpustakaan perguruan tinggi sebagai prime mover peningkatan kompetensi literasi informasi mahasiswa.
Modeling of Methane/Shale Excess Adsorption Under Reservoir Conditions
Authors: Yang Sheng , Wu Wei , Xu Jinze , Ji Dongqi , Chen Zhangxing , Wei Yizheng
Published: November 2018

Micropores and mesopores are the main storage volumes in shale matrix. Because of their small pore sizes, the force between pore boundary and gas molecules is significant. A larger amount of adsorbed gas is in a shale gas reservoir than in a conventional gas reservoir. People usually measure adsorption through volumetric methods under an isothermal condition. Because of a limitation of volumetric methods, only excess adsorption data are directly measured; then, a chosen model is applied to calculate an absolute adsorption through fitting the measured data.

An adsorption process induces changes in free-gas volume. However, the changes in absorbent volume and methane absorption into organic matter also alter the measured gas volume, which is widely neglected in previous studies. In this study, one volume term, which accounts for the unexpected changes in gas volumes caused by the other mechanisms except adsorption, is added to the Dubinin-Astakhov (DA) model (pore-filling theory). The in-situ methane is in a supercritical condition under reservoir conditions. Because of the lack of a saturation pressure of a supercritical fluid, an adsorbed-phase gas density is used to replace the saturation pressure in the DA model.

The modified model is validated by the isothermal adsorption data from four different shale plays. The calculated data by the proposed model have a better match with the measured data than those by the DA model. All shale samples demonstrate a nonmonotonic deformation of adsorbent (volume shrinkage in the low-pressure region, then swelling as pressure increases), which coincides with the results of previous molecular simulation. The key parameters of the proposed model such as a maximum adsorption capacity are more accurate and reasonable than the ones of the DA model. The proposed model provides a good approach to quantify absolute adsorption through experimental data, especially under reservoir conditions, and to emphasize the important effects of volume on methane/shale adsorption.
Coupling of Wellbore and Surface-Facilities Models With Reservoir Simulation To Optimize Recovery of Liquids From Shale Reservoirs
Authors: Fragoso Alfonso , Trick (ret.) Mona D. , Harding Thomas G. , Selvan Karthik , Aguilera Roberto
Published: November 2018

The objective of this paper is to couple wellbore and surface-production-facilities models with reservoir simulation for a shale reservoir that contains dry gas, condensate, and oil in separate geologic containers within the same structure. The goal of this integration is to improve liquid recoveries by dry-gas injection and gas recycling.

Methods previously published investigate possible means of improving recovery from shales and have concentrated on laboratory work and the reservoir itself, but have ignored the wellbore and surface-production facilities. The coupling of these facilities in the simulation work is critical, particularly in cases involving condensate and oil reservoirs, gas injection, and recycling operations. This is so, because a change in pressure in the reservoir is reflected almost immediately in a change in pressure in the wellbore and in the surface installations.

The development presented in this paper considers multistage hydraulically fractured horizontal wells. Dry gas is injected into zones that contain condensate and oil. Gas stripped from the condensate production is reinjected in the condensate zone in a recycling operation. The study focuses on the Eagle Ford Shale, which has separate containers for each fluid within the same structure.

The study leads to the conclusion that, for the studied system, liquid recoveries can be maximized with continuous and huff ’n’ puff gas-injection schemes. In general, huff ’n’ puff injection provides better results in terms of production and economics. Molecular diffusion is found to play a crucial role in continuous gas-injection operations. Conversely, the effect of this phenomenon is negligible in huff ’n’ puff gas injection. This research demonstrates that proper design of wellbore and surface installations, including, for example, downhole pumps and compressors, is important because it plays a critical role in the performance of production and injection operations and in maximizing recovery of liquids from shale reservoirs.

The novelty of the methodology developed in this paper is the coupling of models that handle surface facilities; wellbores; numerical simulation including oil, condensate, and dry-gas reservoirs; gas injection; and gas/condensate-recycling operations. Essentially, the shale containers, wellbore, and surface facilities are continuously “talking” to each other. To the best of our knowledge, this integration for shales has not been published previously in the literature.
Flow Interference Between Hydraulic Fractures
Authors: Weijermars Ruud , van Harmelen Arnaud , Zuo Lihua , Alves Ibere Nascentes , Yu Wei
Published: November 2018

The flow toward hydraulic fractures is visualized at high resolution using a newly developed analytical streamline simulator that is based on complex potentials. Drainage contours show progressive fluid recovery from the stimulated rock volume (SRV). The method plots streamlines, time-of-flight contours, velocity-field contours, and pressure distribution around fractured wells. Independent simulations with a commercial reservoir simulator confirm that visualizations with complex potentials are accurate, and that the latter method provides high-resolution images of the pressure and flow fields around individual fractures. Contours for the drained rock volume (DRV) that are based on particle-velocity tracking outline the actual region drained by a well through its fractures. First, matrix drainage by two-fracture and three-fracture clusters is studied in detail. Flow-separation surfaces between two clustered fractures (with equal length and flux) are always straight, creating planes of symmetry between adjacent drainage regions. Clusters of three fractures develop curved-flow-separation surfaces, convex toward the inner fracture. For fracture spacing less than four times total fracture length, drainage of the central region of the three-fracture clusters slows down because of flow interference, which confirms earlier findings that production gains become insignificant above certain fracture length/spacing ratios. Next, the analysis shows the flow field, drainage contours, velocity contours, and pressure distribution for a horizontal, synthetic well with 11 transversal, kinked fractures. A final section shows a brief example of application to a field case.
Tile Drainage as a Hydrologic Pathway for Phosphorus Export from an Agricultural Subwatershed
Authors: Michaud Aubert R. , Poirier Simon‐Claude , Whalen Joann K.
Published: November 2018

Cyanobacteria growth in Missisquoi Bay of Lake Champlain is triggered by the P load carried by tributaries in surrounding watersheds where agriculture is a dominant land use. The objective of this study was to apportion the total P (TP) load in streamflow from an agricultural subwatershed into distinct hydrologic pathways: groundwater resurgence, surface runoff, and tile drainage components (matrix flow and preferential flow). Stream discharge during peak flow was separated into these four components using electrical conductivity (EC)–discharge relationships developed from the stream water EC at the subwatershed outlet and from EC values of surface runoff and tile drain water in 10 fields within the subwatershed. The four‐component hydrograph model revealed that 46 to 67% of the TP load at the outlet originated from surface runoff during peak flow. Preferential flow was responsible for most of the particulate P and dissolved reactive P loads lost through tile drainage. Groundwater resurgence was a minor source of TP, whereas other sources such as streambank erosion and resuspended sediments contributed up to 21% of the TP load and from 36 to 41% of the particulate P load at the subwatershed outlet. This work confirms that tile drainage contributes to the TP load in agricultural subwatersheds in the Missisquoi Bay region.

Core Ideas

Field water sources affected electrolytes and electrical conductivity in streamflow.

Water yield from field hydrologic pathways was deduced from the stream hydrograph.

Matrix and preferential flows to tile drainage, and surface runoff, were quantified.

Preferential flow was an important source of sediment and P loads in streamflow.

Stream water quality may be negatively affected by tile drainage outflows.
Soil Domain and Liquid Manure Affect Pesticide Sorption in Macroporous Clay Till
Authors: Albers Christian Nyrop , Ernstsen Vibeke , Johnsen Anders Risbjerg
Published: November 2018

Pesticides frequently leach through clayey tills, even when they are expected to be strongly adsorbed. In this study, we observed that sorption of two strongly sorbing pesticides, tebuconazole and glyphosate, varied by more than an order of magnitude across soil domains in 5‐m‐deep clay till profiles with biopores and fractures. Eight soil domains were identified in each of the profiles: five matrix soils and three in the macropores. Tebuconazole sorption was controlled by soil organic matter content, except in the reduced matrix, which was low in organic matter, where there was surprisingly high sorption. Glyphosate showed high variation in sorption between fractures and matrix soil from the same depths. The domain‐specific sorption of both tebuconazole and glyphosate was, however, overruled by dilute liquid manure. Sorption of tebuconazole was, as expected, decreased by liquid manure in several domains, but tebuconazole sorption increased in a few domains due to sorption of the manure‐derived organic matter itself. Liquid manure unexpectedly had a greater effect on glyphosate sorption, which was strongly decreased by dissolved organic matter and phosphate in the manure. The variation in sorption across domains, as well as the effects of liquid manure, should be taken into account when assessing leaching risks.

Core Ideas

Pesticide sorption varied by an order of magnitude across eight domains in a clayey till profile.

Domain‐specific pesticide sorption was overruled by dilute liquid manure.

Dissolved organic matter and phosphate changed glyphosate sorption.

These variations in sorption should be considered in the risk assessment of pesticide leaching.
Options for treatment of atrophic rhinitis of different etiology
Authors: Gurov A. V. , Yushkina M. A.
Published: November 2018

Atrophy is the medical term for shrinkage in the size of an organ, tissue, or a single cell with a corresponding decrease or failure of their function. Rhinitis atrophica simplex is one of the diseases associated with the development of such involutional processes. Atrophic rhinitis is a disease that is a classic example of a chronic pathological process that can be diffuse or local and can be combined with atrophic changes in the nasopharynx and other parts of the pharynx and larynx.
Application of QSAR Analysis and Different Quantum Chemical Calculation Methods in Activity Evaluation of Selected Fluoroquinolones
Authors: Kawczak Piotr , Bober Leszek , Bączek Tomasz
Published: November 2018

Background:

A set of antibiotic fluoroquinolones with confirmed antimicrobial activity
were analyzed with the use of two types of quantum chemical calculation methods and quantitative
structure-activity relationships (QSAR).

Objective:

The purpose of this study was to demonstrate the common and differentiating
characteristics of the above-mentioned chemical compounds alike physicochemically as well as
pharmacologically based on the quantum chemical calculations and microbiological activity data.

Methods:

During the study PCA and MLR analysis were performed, as the types of proposed
chemometric approach. The semi-empirical level of in silico molecular modeling was performed for
calculations of molecular descriptors.

Results:

QSAR models were proposed based on chosen descriptors. The relationship between the
structure and microbiological activity and physicochemical parameters data was able to class and
describe them with the use of statistically significant molecular descriptors.

Conclusion:

The applied chemometric approaches revealed the influential features of tested structures
responsible for the antimicrobial activity of analyzed compounds.
Anxiety Disorders: Sex Differences in Serotonin and Tryptophan Metabolism
Authors: Songtachalert Tanya , Roomruangwong Chutima , Carvalho Andre F. , Bourin Michel , Maes Michael
Published: November 2018

Introduction: Anxiety disorders manifest in women more than in men by almost twofold.
This narrative review aims to summarize the sex-related biological factors, which underpin anxiety, focusing
on the interactions of sex and tryptophan/serotonin with anxiety.

Methods:

A literature search was conducted using Google Scholar, PubMed/MEDLINE, Scopus, and
EMBASE databases from inception until December 31, 2017.

Results:

This review shows that sex may interact with many serotonin functions thereby modulating
anxiety, including 5-HT1A and 5-HT2C receptors, 5-HT transporter and central 5-HT concentrations
and metabolism. Sex-steroids modulate the expression of serotonin transporter genes, creating a difference
in serotonin availability. Sex and estrous cycle phases lead to varying anxiety responses to tryptophan
depletion. Testosterone, progesterone and estrogen are important factors in mediating sex differences
in serotonin responses to anxiety-generating behavioral tests. At prenatal levels, there are sexrelated
differences in the reciprocal relationships between serotonin and the HPA-axis, which modulate
anxiety-like behaviors. Activated immune-inflammatory pathways induce indoleamine-2,3-dioxynease
(IDO) and the tryptophan catabolite (TRYCAT) pathway thereby increasing tryptophan degradation and
increasing the production of TRYCATs including kynurenine and quinolinic acid, which may create an
overall anxiogenic effect. The effects of immune activation on IDO are significantly more pronounced
in women than men, and therefore, females may show increased levels of anxiogenic TRYCAT following
immune challenge. Aberrations in the IDO-activated TRYCAT pathway are found in pregnant females
and parturients and are associated with increased anxiety levels in the postnatal period.

Conclusion:

The results of this review underscore the necessity of studying the associations between
serotonin and anxiety in both sexes taking into account the effects of immune activation on IDO and
production of anxiogenic TRYCATs. Future anxiety research should focus on the interactions between
serotonin/tryptophan and sex, sex hormones, the menstrual cycle, pregnancy, the HPA axis and the immune
system through the production of anxiogenic TRYCATs.
The Natural Products as Hydroxymethylglutaryl-Coa Reductase Inhibitors
Authors: Gulcan Hayrettin Ozan , Yigitkan Serkan , Orhan Ilkay Erdogan
Published: November 2018

High cholesterol and triglyceride levels are mainly related to further generation of lifethreating metabolism disorders including cardiovascular system diseases. Therefore, hypercholesterolemia (i.e., also referred to as hyperlipoproteinemia) is a serious disease state, which must be controlled. Currently, the treatment of hypercholesterolemia is mainly achieved through the employment of statins in the clinic, although there are alternative drugs (e.g., ezetimibe, cholestyramine). In fact, the original statins are natural products directly obtained from fungi-like molds and mushrooms and they are potent inhibitors of hydroxymethylglutaryl-CoA reductase, the key enzyme in the biosynthesis of cholesterol. This review focuses on the first identification of natural statins, their synthetic and semi-synthetic analogues, and the validation of hydroxymethylglutaryl-CoA reductase as a target in the treatment of hypercholesterolemia. Furthermore, other natural products that have been shown to possess the potential to inhibit hydroxymethylglutaryl-CoA reductase are also reviewed with respect to their chemical structures.
Diffusion Tensor Imaging in Preclinical and Human Studies of Huntington’s Disease: What Have we Learned so Far?
Authors: Gatto Rodolfo Gabriel , Weissmann Carina
Published: November 2018

Background:

Huntington’s Disease is an irreversible neurodegenerative disease characterized by the progressive deterioration of specific brain nerve cells. The current evaluation of cellular and physiological events in patients with HD relies on the development of transgenic animal models. To explore such events in vivo, diffusion tensor imaging has been developed to examine the early macro and microstructural changes in brain tissue. However, the gap in diffusion tensor imaging findings between animal models and clinical studies and the lack of microstructural confirmation by histological methods has questioned the validity of this method.

Objective:

This review explores white and grey matter ultrastructural changes associated to diffusion tensor imaging, as well as similarities and differences between preclinical and clinical Huntington’s Disease studies.

Methods:

A comprehensive review of the literature using online-resources was performed (Pub- Med search).

Results:

Similar changes in fractional anisotropy as well as axial, radial and mean diffusivities were observed in white matter tracts across clinical and animal studies. However, comparative diffusion alterations in different grey matter structures were inconsistent between clinical and animal studies.

Conclusion:

Diffusion tensor imaging can be related to specific structural anomalies in specific cellular populations. However, some differences between animal and clinical studies could derive from the contrasting neuroanatomy or connectivity across species. Such differences should be considered before generalizing preclinical results into the clinical practice. Moreover, current limitations of this technique to accurately represent complex multicellular events at the single micro scale are real. Future work applying complex diffusion models should be considered.
Extraction Methods for Obtaining Natural Blue Colorants
Authors: Prado Juliana M. , Veggi Priscilla C. , Náthia-Neves Grazielle , Meireles M. Angela A.
Published: November 2018

Background:

Blue is a color not often present in food. Even so, it is especially attractive
to children. Today, most blue coloring agents used by the food industry are synthetic. With increasing
health issues concern by the scientific community and the general population, there is a trend to look
for natural alternatives to most synthetic products. There only exist few natural blue colorants, which
are presented in a literature survey, along with the methods currently used for their recovery from
natural sources. The best extraction methods and process parameters for the extraction of blue anthocyanins,
iridoids and phycocyanin are discussed.

Methods:

A literature survey was conducted to detect the main sources of blue colorants found in nature.
The focus was on the extraction methods used to recover such molecules, with the objective of
finding efficient and environmentally safe techniques for application at industrial level, and, thus, allowing
the production of natural blue colorants at scale high enough for food industry consumption.

Results:

The main natural blue colorants found in literature are anthocyanins, phycocyanin, and genipin.
While anthocyanins can be recovered from a variety of plants, the source of phycocyanin are
algae, and genipin can be obtained specifically from Gardenia jasminoides Ellis and Genipa americana
L. Several extraction techniques have been applied to recover blue colorants from such sources,
from classical methods using organic solvents, to more sophisticated technologies as ultrasoundassisted
extraction, supercritical fluid extraction, pressurized liquid extraction, high-pressure extraction,
and enzyme-assisted extraction.

Conclusion:

There is great potential for anthocyanins, phycocyanin and genipin use as natural food
additives with health benefits, besides imparting color. However, the technologies for the colorants
recovery and application are not mature enough. Therefore, this area is still developing, and it is necessary
to evaluate the economic feasibility of the proposed extraction processes, along with the safety
and acceptance of colored food using these additives.
The Unprecedented Role of Gold Nanomaterial in Diabetes Management
Authors: Kumari Simpal , Kamboj Vipan Kumar , Rajpoot Diksha , Teotia Anil Kumar , Verma Prabhakar Kumar , Singh Gyanendra Nath
Published: November 2018

:

Gold nanoparticles possess unique mechanical, chemical, photo-optical and biological properties and have been an interesting field of research on life sciences. The research studies produced new nanodevices and nanotechnology-based biosensing, diagnostics therapeutics, and targeted drug delivery systems. In this review, the unique potential aspects of gold nanoparticles/ nanoformulations/ or devices related to diabetes management have been discussed together with the recent patent on the gold nanoparticles developed for diabetes management. The first part of this review will focus on recent strategies for the treatment of hyperglycemia and its management with the help of gold nanoparticles and the second part of the review focused on recent patents on gold nanoparticles useful in the diabetes management. Gold nanoparticles have proved themselves useful in diabetes therapeutics and diagnostics. Due to the high surface area, and low toxicity, gold nanoparticles have become a unique aspect of the delivery approach. The main issues that need to be covered are the biopharmaceutics, biocompatibility, and potential clinical applications.
Effect of Montelukast 10 mg in Elderly Patients with Mild and Moderate Asthma Compared with Young Adults. Results of a Cohort Study
Authors: Sánchez Guillermo , Buitrago Diana
Published: November 2018

Background:

The clinical characteristics and physio-pathogenic mechanisms of asthma in patients older than 60 years appear to differ from the behavior described for other age groups. Therefore, the effectiveness of medications for elderly patients with asthma should not be extrapolated from studies conducted on teenagers or young adults.

Objective:

The study aimed

to establish the clinical effect of montelukast 10 mg in elderly patients with mild and moderate asthma compared to its effect on young adults.

Method:

A prospective cohort study was conducted during 12 weeks of follow-up, which consecutively included the total population of adult patients attended by a group of 21 general practitioners, between July and December 2016. Young adults (18-59 years) and older adults were included (60 years or older) with mild or moderate asthma, which, according to the criteria of his treating physician, had been prescribed montelukast 10 mg/day. The variables of interest were: use of inhaled corticosteroids during the last month, use of inhaled beta-2 adrenergic agonists as a rescue in the last month, having attended the emergency service during the last month due to an asthma attack, presence of wheezing in the physical examination, the number of attacks in the last month and the number of days without symptoms in the last month.

Results:

A total of 126 patients entered the cohort and 104 completed the follow-up, of which 29% were older adults. On admission, 65.4% of patients (68/104) had used rescue inhaled beta2 in the last month and had been using schemes with corticosteroids. After 12 weeks of follow-up, 58.1% (43/74) of the young adults required treatment schedules with corticosteroids, while in the elderly, only 36.7% of the patients (11/30) required this treatment scheme (p-value: 0.047). Regarding the use of rescue inhaled beta-2 at 12 weeks, 55% of young adults reported using them, compared to 33.3% of older adults (p-value: 0.041).

Conclusion:

In this cohort of patients, treated with montelukast 10 mg/day for 12 weeks, there was a reduction of broncho-obstructive symptoms and exacerbations of the disease. In older adults compared to young adults, a greater reduction in the use of beta2 agonists rescue medications and in the concomitant use of inhaled corticosteroid schemes was documented.
Asia’s Reticence Towards Universal Jurisdiction
Authors: Yun Xing
Published: November 2018

Universal jurisdiction is often heralded as an essential tool in the global fight against impunity. For a principle that contains the word “universal” in its name, it is striking though, perhaps unsurprising to discover that only two Asian states have ever exercised it. This paper goes on to provide some context for the Asian experience, positing a few indigenous explanations for Asia’s ambivalence towards this fundamental principle of international criminal law. It will be shown that unlike other areas of international law, Asia cannot hide behind the usual excuse of “refusing to play by Western rules”. The paper concludes by arguing that Asia should take up the unique opportunity it has to shape the future of international criminal law.
Balancing Energy Development and Environmental Rights: From Foreign Litigation to International Insurance?
Authors: Duruigbo Emeka
Published: November 2018

This article examines the use of foreign direct liability suits, including the ones currently in the Dutch court system by Nigerian plaintiffs against Shell Petroleum, to protect environmental and economic interests in oil-producing communities. The paper suggests that while these suits are a valuable tool in advancing the cause of a clean environment, they fall short in accomplishing the goal. Additional tools, such as an international insurance scheme, may need to be introduced to create a more effective framework.
Arbitration in EU Jurisdiction Regulation: Brussels I Recast and a New Proposal
Authors: Dowers Neil , Tang Zheng Sophia
Published: November 2018

The relationship between the European jurisdiction regime and arbitration is one of the areas generating confusion and disputes. The Brussels I Regulation clearly excludes arbitration from its scope to avoid conflicts with the New York Convention, but arbitration-related issues, such as the validity of arbitration agreements, either as an independent claim or an incidental question, frequently arise in courts. The scope of the Brussels I Regulation in terms of arbitration has been addressed by the Court of Justice of the European Union in a number of decisions, such as Marc Rich v Societa Italiano Impianti, Van Uden, and Front Comor. None of them have provided a satisfactory answer. In order to provide clarification and to reconcile the European jurisdiction Regulation and the New York Convention, the Brussels I Recast has inserted a new recital specifically addressing the relationship between court jurisdiction and arbitration. This article aims to assess the effect of the new recital and whether it has appropriately resolved the difficult questions on the relationship between jurisdiction and arbitration in the European Union.
Universal Jurisdiction and Terrorism
Authors: Fernández-Sánchez Pablo Antonio
Published: November 2018

Universal jurisdiction has a relatively long history. There is evidence from the seventeenth century of recourse to this legal institution as a means of avoiding the existence of areas of impunity. State practice, however, is quite recent, emerging from the concepts of war crimes and crimes against humanity. Regardless of how they are classified or categorised, it is within this framework that terrorist acts need to be viewed. The issue of the exercise of universal jurisdiction for crimes classed as terrorism arises when they are qualified by taking into account certain specific acts, such as serious violations of IHL, illegal seizure of aircraft, hostage-taking, kidnapping, acts committed with bombs, etc. Most treaties therefore provide for application of the principle of aut dedere aut judicare as a corollary to universal jurisdiction. However, conventional law, general or specific, is not the only basis for the exercise of universal jurisdiction in the case of terrorism offences. The customary basis is also very important, as are the unilateral acts of states when they legislate or pass judgement taking this framework — conventional or not— into account. The purpose of this article is to analyse all such aspects.
The Evolution of UN Anti-Terrorist Conventions towards the Universal Treaty-Based Model of Combating Terrorism
Authors: Marcinko Marcin
Published: November 2018

Adopted in Montreal in 2014, the Protocol to Amend the Convention on Offences and Certain Other Acts Committed on Board Aircraft is the nineteenth international legal instrument in the acquis of the United Nations (‘UN’) and its related organisations devoted to prevention and suppression of terrorism. Considering the first of such instruments – the Tokyo Convention on Offences and Certain Other Acts Committed on Board Aircraft (‘the Tokyo Convention’) – was adopted in 1963, it may be assumed that throughout the period of 55 years the UN has succeeded in solving the specific model of combating international terrorism. Although the existing and binding international conventions on suppression of terrorism do not form a uniform group and differ in terms of material scope of offences described therein, it is still possible to indicate one significant feature common to all conventions, and that is a set of legal measures and remedies available at the international level which guarantee an effective fight against terrorism. The above-mentioned set of regulatory measures – including, inter alia, jurisdictional clauses – constitutes a consistent collection of rules to be applied in cases of the majority of terrorist activities. The aforesaid model is based on the principle of aut dedere aut judicare supplemented with a rational control of extradition and jurisdictional issues. This model is also enriched with rules concerning other forms of co-operation such as mutual legal assistance, exchange of information and preventive measures. The rationale for the above-referred measures is to ensure that perpetrators of specific international terrorist offences shall be prosecuted regardless of their place of residence or motives that triggered such action. International anti-terrorist conventions adopted under auspices of the UN help to achieve this goal, confronting the internationalisation of terrorism with internationalisation of means and methods of combating this dangerous phenomenon.
Interpretation of International Law by National Judges: Opportunities and Challenges. The Case of International Investment Law in Latin America
Authors: Lozada Gómez Marcelo , Acosta Alvarado Paola
Published: November 2018

The role of national judges in international law is still an undecided subject matter. Most scholars consider the decisions from national judges merely as acts of States, denying the possibility that those judgments constitute an autonomous source of international law. This position is grounded in the idea that national judges do not regularly employ sources of international law, and therefore, their opinion about them is not quite important. Nevertheless, recent phenomena have highlighted and triggered the intervention of national judges regarding the interpretation and enforcement of international law. The growing scope of international rules, which now regulate intra-states issues, as well as the fragmentation of international law, and the internationalisation of national orders, inter alia, have demanded domestic courts’ intervention in order to face these changes and avoid undesirable consequences. In this context, this article aims to: 1. bring an outlook on the evolution of the role assigned to national judges; 2. explore the phenomena that triggered their intervention; 3. analyse the outcomes of this increasing participation, namely how national judges change the usual dynamics of interpretation and evolution of international law; 4. apply these ideas to explain the intervention of national judges in Latin America regarding the enforcement of foreign investment law; and 5. conclude with some remarks about the future of this relationship between national and international law as well as the importance of a better understanding of the role of national judges.
Assessing the contextual factors influencing RFID implementation in hospitals of a developing country: A conceptual model (Preprint)
Authors: Sadeghi Malihe , Ramezani Pour Zahra , Goharinejad Elham , Kahouei Mehdi
Published: November 2018

BACKGROUND

Wasting economic resources in a developing country like Iran will have numerous negative consequences. Thus, in order to avoid possible failures, necessary infrastructures must be provided before implementing new technologies.

OBJECTIVE

The present study aimed at assessing the degree of readiness for implementing RFID in the hospitals of a developing country through a conceptual model.

METHODS

The research study adopted a descriptive design and structural equation modeling was used for data analysis. Data were collected from the hospitals affiliated to Semnan University of Medical Sciences. A questionnaire designed by the researchers was used to collect participants’ ideas about organizational readiness, cultural readiness, and human resource readiness in implementing RFID. Data were fed into Path SPSS (Version 16) and LISREL 8.8, followed by conducting path analysis.

RESULTS

The results showed that human resource readiness significantly predicted RFID implementation, with cultural readiness playing the role of a mediator variable. Cultural readiness itself was influenced by organizational readiness (p<0.01). Cultural factors play an important role in implementing RFID projects in developing countries like Iran.

CONCLUSIONS

Paying more attention to these factors can reduce the risk of failure in implementing such technological projects. Hospitals should strengthen organizational factors and enhance top rank managers’ support for implementing RFID. By so doing, they will promote cultural readiness, prepare human resources, and win the cooperation of the personnel in implementing such a technological project.

CLINICALTRIAL

what is it?
Sleep Quality and Sleep Duration with CKD are Associated with Progression to ESKD
Authors: Yamamoto Ryohei , Shinzawa Maki , Isaka Yoshitaka , Yamakoshi Etsuko , Imai Enyu , Ohashi Yasuo , Hishida Akira ,   for the CKD-JAC Investigators
Published: November 2018

Background and objectives

Shorter or longer sleep duration and poor sleep quality are risk factors for numerous cardio-metabolic diseases, cardiovascular disease, and mortality in subjects with normal kidney function. The association of sleep duration and sleep quality with health outcomes in patients with CKD remains uncertain.

Design, setting, participants, & measurements

A 4-year prospective cohort study in 17 nephrology centers in Japan, the CKD Japan Cohort (CKD-JAC) Study, assessed an association of self-reported sleep duration and sleep quality, on the basis of the Pittsburgh Sleep Quality Index (PSQI) questionnaire, with incidence of ESKD in 1601 patients with eGFR 10–59 ml/min per 1.73 m2 using multivariable-adjusted Cox proportional hazards models.

Results

Baseline sleep duration and PSQI global score for the 1601 patients were mean±SD 7.0±1.3 hours and median 4 (interquartile range, 3–7), respectively. Poor sleep quality (PSQI global score ≥6) was common (n=588 [37%]). During a median of 4.0 (2.6–4.3) years of the follow-up period, 282 (18%) patients progressed to ESKD. After adjusting for age, sex, eGFR, urinary albumin excretion, smoking status, body mass index, history of diabetes and cardiovascular disease, systolic BP, blockade of the renin-angiotensin system, use of hypnotics, and Beck depression inventory score, both shorter (≤5 hour) and longer (>8 hour) sleep duration were associated with ESKD (adjusted hazard ratios [95% confidence intervals] for ≤5.0, 5.1–6.0, 6.1–7.0, 7.1–8.0, and ≥8.0 hours were 2.05 [1.31 to3.21], 0.98 [0.67 to 1.44], 1.00 [reference], 1.22 [0.89 to 1.66], and 1.48 [1.01 to 2.16]), suggesting a U-shaped relationship between sleep duration and ESKD. PSQI global score ≥6 was also associated with incidence of ESKD (adjusted hazard ratios [95% confidence intervals] for PSQI global score ≤5 and ≥6 were 1.00 [reference] and 1.33 [1.03 to 1.71]).

Conclusions

Shorter (≤5 hour) and longer (>8 hour) sleep duration and poor sleep quality (PSQI global score ≥6) were associated with ESKD in patients with CKD.
STUDY OF MAO-B INHIBITOR ANALOUGES FOR PARKINSON’S DISEASE THROUGH CADD APPROACHES
Authors: Bachhar Manish , Singh BK
Published: November 2018

New derivatives are designed as target directed MAO-B Inhibitors for medical care of the patients for neurodegenerative disorder. Molecular design and estimated pharmacokinetic properties have been evaluated by using Inventus v 1.1 software. The binding mode of the proposed compounds with target protein i.e. 1S2Q was evaluated and the resulting data from docking studies explained that newly designed derivatives have high and better affinity towards target protein. Based on these properties, the binding affinities are used for speeding up drug discovery process by eliminating less potent compounds from synthesis.

Keywords: MAO-B, Inventus, Target protein, Neurodegenerative, Docking.
Merlin-Arthur with efficient quantum Merlin and quantum supremacy for the second level of the Fourier hierarchy
Authors: Morimae Tomoyuki , Takeuchi Yuki , Nishimura Harumichi
Published: November 2018

We introduce a simple sub-universal quantum computing model, which we call the Hadamard-classical circuit with one-qubit (HC1Q) model. It consists of a classical reversible circuit sandwiched by two layers of Hadamard gates, and therefore it is in the second level of the Fourier hierarchy. We show that output probability distributions of the HC1Q model cannot be classically efficiently sampled within a multiplicative error unless the polynomial-time hierarchy collapses to the second level. The proof technique is different from those used for previous sub-universal models, such as IQP, Boson Sampling, and DQC1, and therefore the technique itself might be useful for finding other sub-universal models that are hard to classically simulate. We also study the classical verification of quantum computing in the second level of the Fourier hierarchy. To this end, we define a promise problem, which we call the probability distribution distinguishability with maximum norm (PDD-Max). It is a promise problem to decide whether output probability distributions of two quantum circuits are far apart or close. We show that PDD-Max is BQP-complete, but if the two circuits are restricted to some types in the second level of the Fourier hierarchy, such as the HC1Q model or the IQP model, PDD-Max has a Merlin-Arthur system with quantum polynomial-time Merlin and classical probabilistic polynomial-time Arthur.
Linking Postpartum and Parenting Women With a National Diabetes Prevention Program: Recruitment Efforts, Challenges, and Recommendations
Authors: Gómez Maria L. , Hieronymus Laura B. , Ashford Kristin B. , Barnett Janine M. , Renn Theresa A.
Published: November 2018

IN BRIEF Women with a history of gestational diabetes mellitus (GDM) are at higher risk for type 2 diabetes. This project piloted the National Diabetes Prevention Program lifestyle change program in cohorts of women with a history of GDM. The article describes recruitment efforts, challenges, and study participation and provides recommendations for future program implementation.