bluuebunny/crossref_metadata_2025 huggingface dataset:
Dynamic Mechanical Properties of Slag Mortar with Alkali-Resistant Glass Fiber
Authors: Ma Haibin , Yang Shaofan , Xu Ying , Chen Peiyuan , Wang Liang
Published: February 2022

To investigate the influence of alkali-resistant glass fiber on the dynamic mechanical properties and microstructure of slag cement mortar (SCM), five SCM blocks with different volumes of alkali-resistant glass fiber (0%, 0.25%, 0.5%, 0.75%, and 1%) were prepared. A split Hopkinson pressure bar (SHPB) test device with a diameter of Φ50 mm was used to test the impact compression under different loading pressures. In this way, the stress–strain curve of SCM under average strain rates corresponding to different loading air pressures is obtained, and the relationship between the ultimate toughness, the dynamic increase factor (DIF), and the fiber content of SCM can be comprehensively analyzed in combination with the dynamic and static mechanical parameters. Research results showed that, with the increase in fiber content, the static compressive strength of the SCM showed a trend of first increasing and then decreasing, where 0.75% can be the optimal one with the maximum compressive strength. Under the impact load, the dynamic compressive strength of the SCM had a positive correlation with the average strain rate. Within the strain rate range of 75.03 s−1~141.47 s−1, When the fiber volume content is 0.75%, the dynamic compressive strength, ultimate toughness and DIF of SCM are higher than those of other groups, showing good impact resistance. According to the analysis of SEM images, the bonding performance between alkali-resistant glass fiber and cement matrix was strong, and the fibers were interlaced in the mortar to form a network structure, which has a good effect on toughening and strengthening the SCM.
Optimal Control of Chilled Water System Based on Improved Sparrow Search Algorithm
Authors: Zhu Qixin , Zhuang Mengxiang , Liu Hongli , Zhu Yonghong
Published: February 2022

Chilled water systems have large time delays and large inertia, and the traditional PID controller has a poor control effect. In this paper, an improved sparrow search algorithm is proposed to optimize the control of chilled water systems. Firstly, the random walk strategy was used to randomly perturb the sparrows to improve the searching ability of the sparrows. Then, a Gauss mutation was added in the iteration process of sparrows to enhance the local search ability. Finally, the values of the PID parameters as obtained by the above methods were substituted into the controller for simulation. The simulation results show that the method proposed in this paper improves the search accuracy of the sparrow search algorithm and effectively solves the problems of large time delays and large inertia in the chilled water system. The method in this paper took the least amount of time for the system to reach the steady state at only 12.75 s. The control effect of the proposed method was also better than that of the improved ant colony optimization algorithm. The rise time was 2.713 s, and the adjustment time was 4.95 s.
Human Cytomegalovirus Seropositivity and Viral DNA in Breast Tumors Are Associated with Poor Patient Prognosis
Authors: Yang Zelei , Tang Xiaoyun , Hasing Maria Eloisa , Pang Xiaoli , Ghosh Sunita , McMullen Todd P. W. , Brindley David N. , Hemmings Denise G.
Published: February 2022

Human cytomegalovirus (HCMV) infects 40–70% of adults in developed countries. Detection of HCMV DNA and/or proteins in breast tumors varies considerably, ranging from 0–100%. In this study, nested PCR to detect HCMV glycoprotein B (gB) DNA in breast tumors was shown to be sensitive and specific in contrast to the detection of DNA for immediate early genes. HCMV gB DNA was detected in 18.4% of 136 breast tumors while 62.8% of 94 breast cancer patients were seropositive for HCMV. mRNA for the HCMV immediate early gene was not detected in any sample, suggesting viral latency in breast tumors. HCMV seropositivity was positively correlated with age, body mass index and menopause. Patients who were HCMV seropositive or had HCMV DNA in their tumors were 5.61 (CI 1.77–15.67, p = 0.003) or 5.27 (CI 1.09–28.75, p = 0.039) times more likely to develop Stage IV metastatic tumors, respectively. Patients with HCMV DNA in tumors experienced reduced relapse-free survival (p = 0.042). Being both seropositive with HCMV DNA-positive tumors was associated with vascular involvement and metastasis. We conclude that determining the seropositivity for HCMV and detection of HCMV gB DNA in the breast tumors could identify breast cancer patients more likely to develop metastatic cancer and warrant special treatment.
Contemporary Management of Locally Advanced and Recurrent Rectal Cancer: Views from the PelvEx Collaborative
Authors: PelvEx Collaborative PelvEx Collaborative
Published: February 2022

Pelvic exenteration is a complex operation performed for locally advanced and recurrent pelvic cancers. The goal of surgery is to achieve clear margins, therefore identifying adjacent or involved organs, bone, muscle, nerves and/or vascular structures that may need resection. While these extensive resections are potentially curative, they can be associated with substantial morbidity. Recently, there has been a move to centralize care to specialized units, as this facilitates better multidisciplinary care input. Advancements in pelvic oncology and surgical innovation have redefined the boundaries of pelvic exenterative surgery. Combined with improved neoadjuvant therapies, advances in diagnostics, and better reconstructive techniques have provided quicker recovery and better quality of life outcomes, with improved survival This article provides highlights of the current management of advanced pelvic cancers in terms of surgical strategy and potential future developments.
Advance of SOX Transcription Factors in Hepatocellular Carcinoma: From Role, Tumor Immune Relevance to Targeted Therapy
Authors: Luo Xiangyuan , Ji Xiaoyu , Xie Meng , Zhang Tongyue , Wang Yijun , Sun Mengyu , Huang Wenjie , Xia Limin
Published: February 2022

Sex determining region Y (SRY)-related high-mobility group (HMG) box (SOX) factors belong to an evolutionarily conserved family of transcription factors that play essential roles in cell fate decisions involving numerous developmental processes. In recent years, the significance of SOX factors in the initiation and progression of cancers has been gradually revealed, and they act as potential therapeutic targets for cancer. However, the research involving SOX factors is still preliminary, given that their effects in some leading-edge fields such as tumor immune microenvironment (TIME) remain obscure. More importantly, as a class of ‘undruggable’ molecules, targeting SOX factors still face considerable challenges in achieving clinical translation. Here, we mainly focus on the roles and regulatory mechanisms of SOX family members in hepatocellular carcinoma (HCC), one of the fatal human health burdens worldwide. We then detail the role of SOX members in remodeling TIME and analyze the association between SOX members and immune components in HCC for the first time. In addition, we emphasize several alternative strategies involved in the translational advances of SOX members in cancer. Finally, we discuss the alternative strategies of targeting SOX family for cancer and propose the opportunities and challenges they face based on the current accumulated studies and our understanding.
The Bilateral Interplay between Cancer Immunotherapies and Neutrophils’ Phenotypes and Sub-Populations
Authors: Kaisar-Iluz Naomi , Arpinati Ludovica , Shaul Merav E. , Mahroum Sojod , Qaisi Mohamad , Tidhar Einat , Fridlender Zvi G.
Published: February 2022

Immunotherapy has become a leading modality for the treatment of cancer, but despite its increasing success, a substantial number of patients do not benefit from it. Cancer-related neutrophils have become, in recent years, a subject of growing interest. Distinct sub-populations of neutrophils have been identified at advanced stages of cancer. In this study, we aimed to evaluate the role of neutrophils in mediating the efficacy of immune checkpoint inhibitors (ICI) treatments (α-PD-1/PD-L1), by assessing lung tumor models in mice. We found that G-CSF overexpression by the tumor significantly potentiates the efficacy of ICI, whereas neutrophils’ depletion abrogated their responses. Adoptive transfer of circulating normal-density neutrophils (NDN) resulted in significantly reduced tumor growth, whereas low-density neutrophils (LDN) had no effect. We next investigated the effect of ICI on neutrophils’ functions. Following α-PD-L1 treatment, NDN displayed increased ROS production and increased cytotoxicity toward tumor cells but decreased degranulation. Together, our results suggest that neutrophils are important mediators of the ICI treatments and that mainly NDN are modulated following α-PD-L1 treatment. This research provides a better understanding of the function of neutrophils following immunotherapies and their impact on the efficacy of immunotherapy, supporting better understanding and future improvement of currently available treatments.
The Splicing Variant TFIIIA-7ZF of Viroid-Modulated Transcription Factor IIIA Causes Physiological Irregularities in Transgenic Tobacco and Transient Somatic Depression of “Degradome” Characteristic for Developing Pollen
Authors: Matoušek Jaroslav , Steger Gerhard
Published: February 2022

Viroids are small, non-coding, pathogenic RNAs with a significant ability of adaptation to several basic cellular processes in plants. TFIIIA-7ZF, a splicing variant of transcription factor IIIA, is involved in replication of nuclear-replicating viroids by DNA-dependent polymerase II. We overexpressed NbTFIIIA-7ZF from Nicotiana benthamiana in tobacco (Nicotiana tabacum) where it caused morphological and physiological deviations like plant stunting, splitting of leaf petioles, pistils or apexes, irregular branching of shoots, formation of double-blade leaves, deformation of main stems, and modification of glandular trichomes. Plant aging and senescence was dramatically delayed in transgenic lines. Factors potentially involved in viroid degradation and elimination in pollen were transiently depressed in transgenic leaves. This depressed “degradome” in young plants involved NtTudor S-like nuclease, dicers, argonoute 5, and pollen extracellular nuclease I showing expression in tobacco anthers and leaves. Analysis of the “degradome” in tobacco leaves transformed with either of two hop viroids confirmed modifications of the “degradome” and TFIIIA expression. Thus, the regulatory network connected to TFIIIA-7ZF could be involved in plant pathogenesis as well as in viroid adaptation to avoid its degradation. These results support the hypothesis on a significant impact of limited TFIIIA-7ZF on viroid elimination in pollen.
Neutrophil Extracellular Traps Do Not Induce Injury and Inflammation in Well-Differentiated RSV-Infected Airway Epithelium
Authors: Linssen Rosalie S. N. , Sridhar Adithya , Moreni Giulia , van der Wel Nicole N. , van Woensel Job B. M. , Wolthers Katja C. , Bem Reinout A.
Published: February 2022

Respiratory syncytial virus (RSV) lower respiratory tract infection (LRTI) causes a major burden of disease. The host response in RSV-LRTI is characterized by airway epithelial injury, inflammation and neutrophil influx, with the formation of neutrophil extracellular traps (NETs). However, the precise role of NETs in the pathophysiology of RSV-LRTI remains to be elucidated. Here, we used well-differentiated human airway epithelial cultures (HAE) of a pediatric and adult donor to study whether NETs cause airway epithelial injury and inflammation in the setting of RSV infection. The exposure of uninfected and RSV-infected HAE cultures to NETs, as produced by stimulation of neutrophils by a low dose of phorbol 12-myristate 13-acetate (PMA), did not induce or aggravate cell injury or inflammation. RSV infection of HAE cultures caused release of pro-inflammatory cytokines such as IL-6 and RANTES in both adult and pediatric cultures, but the differential gene expression for regulated cell death differed between culture donors. In this in vitro airway epithelial model, NETs in the setting of RSV infection did not cause or aggravate epithelial injury or inflammation.
DNA Methyltransferase 3b in Myeloid Cells Does Not Affect the Acute Immune Response in the Airways during Pseudomonas Pneumonia
Authors: Qin Wanhai , Brands Xanthe , van’t Veer Cornelis , de Vos Alex F. , Scicluna Brendon P. , van der Poll Tom
Published: February 2022

DNA methyltransferase 3b (Dnmt3b) has been suggested to play a role in the host immune response during bacterial infection. Neutrophils and other myeloid cells are crucial for lung defense against Pseudomonas (P.) aeruginosa infection. This study aimed to investigate the role of Dnmt3b in neutrophils and myeloid cells during acute pneumonia caused by P. aeruginosa. Neutrophil-specific (Dnmt3bfl/flMrp8Cre) or myeloid cell-specific (Dnmt3bfl/flLysMCre) Dnmt3b-deficient mice and littermate control mice were infected with P. aeruginosa PAK via the airways. Bacteria burdens, neutrophil recruitment, and activation (CD11b expression, myeloperoxidase, and elastase levels), interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF) were measured in bronchoalveolar lavage fluid (BALF) at 6 and 24 h after infection. Our data showed that the bacterial loads and neutrophil recruitment and activation did not differ in BALF obtained from neutrophil-specific Dnmt3b-deficient and control mice, whilst BALF IL-6 and TNF levels were lower in the former group at 24 but not at 6 h after infection. None of the host response parameters measured differed between myeloid cell-specific Dnmt3b-deficient and control mice. In conclusion, dnmt3b deficiency in neutrophils or myeloid cells does not affect acute immune responses in the airways during Pseudomonas pneumonia.
Cerebral Biomarkers and Blood-Brain Barrier Integrity in Preeclampsia
Authors: Friis Therese , Wikström Anna-Karin , Acurio Jesenia , León José , Zetterberg Henrik , Blennow Kaj , Nelander Maria , Åkerud Helena , Kaihola Helena , Cluver Catherine , Troncoso Felipe , Torres-Vergara Pablo , Escudero Carlos , Bergman Lina
Published: February 2022

Cerebral complications in preeclampsia contribute substantially to maternal mortality and morbidity. There is a lack of reliable and accessible predictors for preeclampsia-related cerebral complications. In this study, plasma from women with preeclampsia (n = 28), women with normal pregnancies (n = 28) and non-pregnant women (n = 16) was analyzed for concentrations of the cerebral biomarkers neurofilament light (NfL), tau, neuron-specific enolase (NSE) and S100B. Then, an in vitro blood–brain barrier (BBB) model, based on the human cerebral microvascular endothelial cell line (hCMEC/D3), was employed to assess the effect of plasma from the three study groups. Transendothelial electrical resistance (TEER) was used as an estimation of BBB integrity. NfL and tau are proteins expressed in axons, NSE in neurons and S100B in glial cells and are used as biomarkers for neurological injury in other diseases such as dementia, traumatic brain injury and hypoxic brain injury. Plasma concentrations of NfL, tau, NSE and S100B were all higher in women with preeclampsia compared with women with normal pregnancies (8.85 vs. 5.25 ng/L, p < 0.001; 2.90 vs. 2.40 ng/L, p < 0.05; 3.50 vs. 2.37 µg/L, p < 0.001 and 0.08 vs. 0.05 µg/L, p < 0.01, respectively). Plasma concentrations of NfL were also higher in women with preeclampsia compared with non-pregnant women (p < 0.001). Higher plasma concentrations of the cerebral biomarker NfL were associated with decreased TEER (p = 0.002) in an in vitro model of the BBB, a finding which indicates that NfL could be a promising biomarker for BBB alterations in preeclampsia.
Effects of the Mutant TP53 Reactivator APR-246 on Therapeutic Sensitivity of Pancreatic Cancer Cells in the Presence and Absence of WT-TP53
Authors: Abrams Stephen L. , Duda Przemysław , Akula Shaw M. , Steelman Linda S. , Follo Matilde L. , Cocco Lucio , Ratti Stefano , Martelli Alberto M. , Montalto Giuseppe , Emma Maria Rita , Cervello Melchiorre , Rakus Dariusz , Gizak Agnieszka , McCubrey James A.
Published: February 2022

The TP53 tumor suppressor is mutated in ~75% of pancreatic cancers. The mutant TP53 protein in pancreatic ductal adenocarcinomas (PDAC) promotes tumor growth and metastasis. Attempts have been made to develop molecules that restore at least some of the properties of wild-type (WT) TP53. APR-246 is one such molecule, and it is referred to as a mutant TP53 reactivator. To understand the potential of APR-246 to sensitize PDAC cells to chemotherapy, we introduced a vector encoding WT-TP53 into two PDAC cell lines, one lacking the expression of TP53 (PANC-28) and one with a gain-of-function (GOF) mutant TP53 (MIA-PaCa-2). APR-246 increased drug sensitivity in the cells containing either a WT or mutant TP53 protein with GOF activity, but not in cells that lacked TP53. The introduction of WT-T53 into PANC-28 cells increased their sensitivity to the TP53 reactivator, chemotherapeutic drugs, and signal transduction inhibitors. The addition of WT-TP53 to PDAC cells with GOF TP53 also increased their sensitivity to the drugs and therapeutics, indicating that APR-246 could function in cells with WT-TP53 and GOF TP53. These results highlight the importance of knowledge of the type of TP53 mutation that is present in cancer patients before the administration of drugs which function through the reactivation of TP53.
Physicochemical Characterization of Europium-Doped Hydroxyapatite Thin Films with Antifungal Activity
Authors: Ciobanu Carmen Steluta , Predoi Mihai Valentin , Buton Nicolas , Megier Christelle , Iconaru Simona Liliana , Predoi Daniela
Published: February 2022

Owing to its unique biological and physicochemical properties, hydroxyapatite (HAp) represents one of the most extensively studied biomaterials for biomedical applications. It is well known that Candida is currently one of the fungi frequently involved in the onset and development of post-implant infections and, owing to the appearance of antifungal resistance, it is quite difficult to treat despite all the tremendous efforts made in this regard by the scientific world. Therefore, in this context, we report for the first time in this paper, the development and characterization of europium-doped thin films (5EuHAp, xEu = 0.05) on a Si substrate by a spin-coating method. The results of ultrasound (US), zeta (ζ) potential, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), scanning electron microscopy (SEM), and Fourier-transform infrared spectroscopy (FTIR) studies are presented. The XRD studies conducted on 5EuHAp suspension revealed the nanometric dimensions of the particles and sample purity. In addition, a moderate stability of the 5EuHAp suspension was observed. XPS measurements revealed the presence of Eu 3d in the 5EuHAp thin films. In the SEM micrographs, the surface uniformity and the absence of the surface defects could be observed. Moreover, the results of the FTIR studies showed the presence of the vibrational bands specific to the HAp structure in the studied sample. The antifungal activity of the HAp and 5EuHAp suspensions and coatings was evaluated using the Candida albicans ATCC 10231 (C. albicans) fungal strain. The qualitative assays of the antifungal properties of HAp and 5EuHAp coatings were also visualized by SEM and CLSM. The antifungal studies revealed that both 5EuHAp suspensions and coatings exhibited noticeable antifungal activity against C. albicans cells.
Cyclohexylammonium Hexaisothiocyanatonickelate(II) Dihydrate as a Single-Source Precursor for High Surface Area Nickel Oxide and Sulfide Nanocrystals
Authors: Aboud Mohamed F. Aly , BinTaleb Abdulmalik M. , Yahia Hamdi Ben , Albaid Abdelhamid , Albishi Sultan , Arasheed Rasheed , Albinali Ibrahim , Albaqi Fahad , Anojaidi Khalid , Alqahtani Fahad , Alenad Asma M. , Taha Kamal , Bagabas Abdulaziz
Published: February 2022

Cyclohexylammonium hexaisothiocyanatonickelate(II) dihydrate, (C6H11NH3)4[Ni(NCS)6]·2H2O, was synthesized, for the first time, by a four-step method in a yield of 95%. The compound was fully characterized by elemental microanalysis, Fourier transform infrared (FTIR), ultraviolet-visible-near infrared (UV-Vis-NIR), and nuclear magnetic resonance (NMR) spectroscopy and thermogravimetry. A single crystal X-ray diffraction (SXRD) gave the monoclinic space group P21/c with a = 15.8179 (5) Å, b = 10.6222 (3) Å, c = 13.8751 (4) Å, β = 109.362 (1)°, V = 2199.45 (11) Å3, Z = 2 (T = 293 K) for this novel hybrid organic–inorganic compound. The title compound was employed as a single-source precursor for the synthesis of mesoporous, high surface area nickel oxide (53 Å; 452 m2/g) and nickel sulfide (46 Å; 220 m2/g) via pyrolysis under air at 550 °C or helium atmosphere at 500 °C, respectively. X-ray powder diffraction (XRPD) demonstrated the nanocrystalline nature of both NiO and NiS with an average crystallite size of 16 and 54 nm, respectively. Scanning electron microscope (SEM) indicated the formation of agglomerated, quasi-spherical particles of nickel oxide and agglomerated flake-like structures of nickel sulfide. The high surface area, porosity, and nanocrystallinity of both NiO and NiS, obtained via this approach, are promising for a wide spectrum of applications.
Urothelial Bladder Carcinomas with High Tumor Mutation Burden Have a Better Prognosis and Targetable Molecular Defects beyond Immunotherapies
Authors: Voutsadakis Ioannis A.
Published: February 2022

Background: Urothelial bladder carcinomas had traditionally been difficult to treat cancers, with high morbidity and mortality rates when invasive and metastatic. In recent years, immunotherapy with immune checkpoint inhibitors has improved outcomes in several cancers, including bladder carcinomas. Despite positive overall results, many bladder cancer patients do not respond to immunotherapies. Validated predictive biomarkers of response would advance the selection of patients for these treatments. Tumor mutation burden (TMB) has been suggested as an immunotherapy biomarker and thus delineation of attributes of tumors with a high TMB is clinically relevant. Methods: Publicly available genomic and clinical data from the urothelial bladder carcinoma cohort of The Cancer Genome Atlas (TCGA) project are used to analyze characteristics and molecular alterations of the subset of cancers with an increased tumor mutation number compared with those with lower number of mutations. The cut-off for the high mutation burden in the analysis was set at 10 mutations per Megabase (MB). Results: In addition to their sensitivity to immune checkpoint inhibitors, urothelial carcinomas with high TMB possess several molecular defects that could be exploited for combinatorial treatments. Compared with bladder carcinomas with low TMB, carcinomas with high TMB display higher prevalence of mutations in tumor suppressor TP53, PIK3CA, in FAT4 cadherin and in genes encoding for several epigenetic modifier enzymes. The frequency of mutations in mismatch repair and DNA damage response genes is higher in cancers with high TMB. The group of urothelial carcinomas with high TMB has a better prognosis than the group with low TMB. This improved Overall Survival (OS) stems from improved survival of stage III cancers with high TMB compared with stage III cancers with low TMB, while stage II and stage IV cancers have similar OS, independently of their TMB. Conclusion: Differences of the landscape of high and low TMB urothelial cancers provides leads for further pathogenesis investigations and may prove useful for development of combination therapies including immunotherapies with targeted inhibitors.
Radiomics in Cross-Sectional Adrenal Imaging: A Systematic Review and Quality Assessment Study
Authors: Stanzione Arnaldo , Galatola Roberta , Cuocolo Renato , Romeo Valeria , Verde Francesco , Mainenti Pier Paolo , Brunetti Arturo , Maurea Simone
Published: February 2022

In this study, we aimed to systematically review the current literature on radiomics applied to cross-sectional adrenal imaging and assess its methodological quality. Scopus, PubMed and Web of Science were searched to identify original research articles investigating radiomics applications on cross-sectional adrenal imaging (search end date February 2021). For qualitative synthesis, details regarding study design, aim, sample size and imaging modality were recorded as well as those regarding the radiomics pipeline (e.g., segmentation and feature extraction strategy). The methodological quality of each study was evaluated using the radiomics quality score (RQS). After duplicate removal and selection criteria application, 25 full-text articles were included and evaluated. All were retrospective studies, mostly based on CT images (17/25, 68%), with manual (19/25, 76%) and two-dimensional segmentation (13/25, 52%) being preferred. Machine learning was paired to radiomics in about half of the studies (12/25, 48%). The median total and percentage RQS scores were 2 (interquartile range, IQR = −5–8) and 6% (IQR = 0–22%), respectively. The highest and lowest scores registered were 12/36 (33%) and −5/36 (0%). The most critical issues were the absence of proper feature selection, the lack of appropriate model validation and poor data openness. The methodological quality of radiomics studies on adrenal cross-sectional imaging is heterogeneous and lower than desirable. Efforts toward building higher quality evidence are essential to facilitate the future translation into clinical practice.
Quantum Bitcoin Mining
Authors: Benkoczi Robert , Gaur Daya , Nagy Naya , Nagy Marius , Hossain Shahadat
Published: February 2022

This paper studies the effect of quantum computers on Bitcoin mining. The shift in computational paradigm towards quantum computation allows the entire search space of the golden nonce to be queried at once by exploiting quantum superpositions and entanglement. Using Grover’s algorithm, a solution can be extracted in time O(2256/t), where t is the target value for the nonce. This is better using a square root over the classical search algorithm that requires O(2256/t) tries. If sufficiently large quantum computers are available for the public, mining activity in the classical sense becomes obsolete, as quantum computers always win. Without considering quantum noise, the size of the quantum computer needs to be ≈104 qubits.
Mixedness, Coherence and Entanglement in a Family of Three-Qubit States
Authors: Kalaga Joanna K. , Leoński Wiesław , Szczȩśniak Radosław , Peřina Jan
Published: February 2022

We consider a family of states describing three-qubit systems. We derived formulas showing the relations between linear entropy and measures of coherence such as degree of coherence, first- and second-order correlation functions. We show that qubit–qubit states are strongly entangled when linear entropy reaches some range of values. For such states, we derived the conditions determining boundary values of linear entropy parametrized by measures of coherence.
Restricted Access to Working Memory Does Not Prevent Cumulative Score Improvement in a Cultural Evolution Task
Authors: Dunstone Juliet , Atkinson Mark , Renner Elizabeth , Caldwell Christine A.
Published: February 2022

Some theories propose that human cumulative culture is dependent on explicit, system-2, metacognitive processes. To test this, we investigated whether access to working memory is required for cumulative cultural evolution. We restricted access to adults’ working-memory (WM) via a dual-task paradigm, to assess whether this reduced performance in a cultural evolution task, and a metacognitive monitoring task. In total, 247 participants completed either a grid search task or a metacognitive monitoring task in conjunction with a WM task and a matched control. Participants’ behaviour in the grid search task was then used to simulate the outcome of iterating the task over multiple generations. Participants in the grid search task scored higher after observing higher-scoring examples, but could only beat the scores of low-scoring example trials. Scores did not differ significantly between the control and WM distractor blocks, although more errors were made when under WM load. The simulation showed similar levels of cumulative score improvement across conditions. However, scores plateaued without reaching the maximum. Metacognitive efficiency was low in both blocks, with no indication of dual-task interference. Overall, we found that taxing working-memory resources did not prevent cumulative score improvement on this task, but impeded it slightly relative to a control distractor task. However, we found no evidence that the dual-task manipulation impacted participants’ ability to use explicit metacognition. Although we found minimal evidence in support of the explicit metacognition theory of cumulative culture, our results provide valuable insights into empirical approaches that could be used to further test predictions arising from this account.
Robust Beamforming Based on Graph Attention Networks for IRS-Assisted Satellite IoT Communications
Authors: Cao Hailin , Zhu Wang , Feng Wenjuan , Fan Jin
Published: February 2022

Satellite communication is expected to play a vital role in realizing Internet of Remote Things (IoRT) applications. This article considers an intelligent reflecting surface (IRS)-assisted downlink low Earth orbit (LEO) satellite communication network, where IRS provides additional reflective links to enhance the intended signal power. We aim to maximize the sum-rate of all the terrestrial users by jointly optimizing the satellite’s precoding matrix and IRS’s phase shifts. However, it is difficult to directly acquire the instantaneous channel state information (CSI) and optimal phase shifts of IRS due to the high mobility of LEO and the passive nature of reflective elements. Moreover, most conventional solution algorithms suffer from high computational complexity and are not applicable to these dynamic scenarios. A robust beamforming design based on graph attention networks (RBF-GAT) is proposed to establish a direct mapping from the received pilots and dynamic network topology to the satellite and IRS’s beamforming, which is trained offline using the unsupervised learning approach. The simulation results corroborate that the proposed RBF-GAT approach can achieve more than 95% of the performance provided by the upper bound with low complexity.
COVID-19’s Impact on International Trade
Authors: Coquidé Célestin , Lages José , Ermann Leonardo , Shepelyansky Dima L.
Published: February 2022

We analyze how the COVID-19 pandemic affected the trade of products between countries. With this aim, using the United Nations Comtrade database, we perform a Google matrix analysis of the multiproduct World Trade Network (WTN) for the years 2018–2020, comprising the emergence of the COVID-19 as a global pandemic. The applied algorithms—PageRank, CheiRank and the reduced Google matrix—take into account the multiplicity of the WTN links, providing new insights into international trade compared to the usual import–export analysis. These complex networks analysis algorithms establish new rankings and trade balances of countries and products considering all countries on equal grounds, independent of their wealth, and every product on the basis of its relative exchanged volumes. In comparison with the pre-COVID-19 period, significant changes in these metrics occurred for the year 2020, highlighting a major rewiring of the international trade flows induced by the COVID-19 pandemic crisis. We define a new PageRank–CheiRank product trade balance, either export or import-oriented, which is significantly perturbed by the pandemic.
Development of a Grinding Tool with Contact-Force Control Capability
Authors: Lin Yu-Heng , Liu Ming-Wei , Lin Pei-Chun
Published: February 2022

The grinding normal force is one of the main factors that affect grinding quality. We report on the development of a compact grinding tool which not only can rotate the grind wheel but also can actively control the wheel in the fore/aft direction to modulate the contact force. The two motion degrees of freedom are coupled in the sense of mechanism yet their motions are independent. The designed grinding tool was modeled and its parameters were systemically identified. A repetitive controller was designed to suppress periodic force variation, which was mainly caused by the rotational motion of the grinding wheel, and the results were compared with other control methods. The selection of the grinding parameters was conducted using the Taguchi method. Finally, the grinding tool and the repetitive controller were experimentally evaluated, and the experimental results confirm that the proposed control strategy can reduce the force disturbance and improve the surface quality of the flat and curvy workpieces.
Self-Healing Silicones for Outdoor High Voltage Insulation: Mechanism, Applications and Measurements
Authors: Kamand Fadi Z. , Mehmood Basharat , Ghunem Refat , Hassan Mohammad K. , El-Hag Ayman , Al-Sulaiti Leena , Abdala Ahmed
Published: February 2022

This paper discusses the state of the art in the application of self-healing silicone-based materials for outdoor high-voltage insulation. Both the dynamic behavior of the dimethyl side groups of silicone rubber and the diffusion of a bulk siloxane to maintain low surface energy are respectively reported as intrinsic mechanisms responsible for the self-healing of silicone rubber. Localization, temporality, mobility, and the type of synthesis are the aspects defining the efficiency of the self-healing ability of silicone rubber. In addition, the deterioration of the self-healing ability with filler loaded into silicone rubber insulation housing composites is discussed. Taking the self-healing property into consideration among the other properties of silicone rubber insulators, such as tracking and erosion resistance, can be a useful design practice at the material development stage. Hydrophobicity retention, recovery, and transfer measurements are discussed as useful indicators of the self-healing ability of silicone rubber. Nevertheless, there remains a need to standardize them as design tests at the material development stage. The paper is intended to shed the light on the hydrophobicity recovery, a key material design parameter in the development of silicone rubber outdoor insulating composites, similar to the tracking and erosion resistance.
Design and Control of Modular Multilevel Converter for Voltage Sag Mitigation
Authors: Muhammad Fazal , Rasheed Haroon , Ali Ihsan , Alroobaea Roobaea , Binmahfoudh Ahmed
Published: February 2022

Voltage sag in a power system is an unavoidable power quality issue, and it is also an urgent concern of sensitive industrial users. To ensure the power quality demand and economical operation of the power system, voltage sag management has always drawn great attention from researchers around the world. The latest research that realizes the power quality conditioning has used dynamic voltage restorers (DVRs), static VAR compensator (SVCs), adaptive neuro-fuzzy inference systems (ANFISs), and fuzzy logic controllers based on DVR to mitigate voltage sag. These devices, methods, and control strategies that have been recently used for voltage sag mitigation have some limitations, including high cost, increased complexity, and lower performance. This article proposes a novel, efficient, reliable, and cost-effective voltage sag mitigation scheme based on a modular multilevel converter (MMC) that ensures effective power delivery at nominal power under transient voltage conditions. The proposed method, the MMC, compensates for the energy loss caused by voltage sags using its internal energy storage of the submodules, and ensures reliable power delivery to the load distribution system. Furthermore, control strategies are developed for the MMC to control DC voltage, AC voltage, active power, and circulating current. Detailed system mathematical models of controllers are developed in the dual synchronous reference frame (DSRF). Validation of the results of back-to-back MMC for dynamic load distribution system is analyzed which proves the effectiveness of the proposed scheme for voltage sag mitigation.
Design and Analysis of a Multi-Input Multi-Output System for High Power Based on Improved Magnetic Coupling Structure
Authors: Zhang Zijia , Liu Jun , Li Yansong
Published: February 2022

Conventional inductive contactless power transfer (ICPT) systems have only one energy transmission path, which makes it challenging to meet the power transmission requirements of high-power and reliability. This study proposes a novel multiple-input multiple-output (MIMO) ICPT system. The three-dimensional finite element analysis tool COMSOL is utilised to study various magnetic coupling structures, analyse the influence of cross-coupling between coils on the same side, design the circuit based on this, propose a parameter configuration method for resonance compensation, and, finally, build an experimental platform with small magnetic coupling structures for single-input single-output systems (SISO) and MIMO systems. The results indicate that the co-directional connection of the coils of the E-shaped and UE-shaped magnetic coupling structures has a strengthening effect on the secondary side coupling. The magnetic coupling structure of the E-shaped iron core exhibits the best transmission performance. The transmission power of the MIMO system with the E-shaped magnetic coupling structure as the core device is significantly improved. In addition, the output power is unchanged after a secondary side fault, which verifies the accuracy of the proposed method.
Distribution Network Reconfiguration Considering Voltage and Current Unbalance Indexes and Variable Demand Solved through a Selective Bio-Inspired Metaheuristic
Authors: Gerez Cassio , Coelho Marques Costa Eduardo , Sguarezi Filho Alfeu J.
Published: February 2022

Operation of distribution networks involves a series of criteria that should be met, aiming for the correct and optimal behavior of such systems. Some of the major drawbacks found when studying these networks is the real losses related to them. To overcome this problem, distribution network reconfiguration (DNR) is an efficient tool due to the low costs involved in its implementation. The majority of studies regarding this subject treat the problem by considering networks only as three-phase balanced, modeled as single-phase grids with fixed power demand, which is far from representing the characteristics of real networks (e.g., unbalanced loads, variable power and unbalance indexes). Due to the combinatorial nature of the problem, metaheuristic techniques are powerful tools for the inclusion of such characteristics. In this sense, this paper proposes a study of DNR considering balanced and unbalanced systems with variable power demand. An analysis of the direct influence of voltage unbalance index (VUI) and current unbalance index (CUI) is carried out for unbalanced cases. To solve the DNR problem, a selective bio-inspired metaheuristic based on micro bats’ behavior named the selective bat algorithm (SBAT) is used together with the EPRI-OpenDSS software (California, US, EPRI). Tests are initially conducted on balanced systems, aiming to validate the technique proposed for both demands and state their differences, and then they are conducted on unbalanced systems to study the influence of VUI and CUI in the DNR solution.
Mesh-Based 3D MEC Modeling of a Novel Hybrid Claw Pole Generator
Authors: Cao Yu , Liu Chuang , Yu Junyue
Published: February 2022

A brushless parallel hybrid excitation claw pole generator (HECPG) is proposed for electric vehicle (EV) application. Permanent magnet (PM) excitation method can reduce the volume of the machine and improve the power density and efficiency. Moreover, the voltage regulation can be ensured by field excitation. The flux path of the proposed HECPG is complex, and it will take a long time for 3D finite element analysis (FEA) to process it. To reduce simulation time, the mathematical model of the generator is given by a mesh-based 3D magnet equivalent circuit (MEC) network method considering radial and axial flux, magnetic saturation, and magnetic flux leakage. The performance of the generator is analyzed by FEA and prototype experiment. Finally, the results of 3D MEC, FEA, and experiment are compared. There is little difference between the three results, so 3D MEC can ensure the accuracy and significantly reduce the simulation time. The efficiency of the proposed HECPG is 90%, and the DC-Bus voltage can be modulated by changing the amplitude of field current.
Patterns and Abundance of Rare Earth Elements in Sediments of a Bedrock River (Miño River, NW Iberian Peninsula)
Authors: Álvarez-Vázquez Miguel Ángel , De Uña-Álvarez Elena , Prego Ricardo
Published: February 2022

Bedrock rivers, whose sedimentary geochemistry has been scarcely investigated, are suitable to test geochemical approaches in order to assess the existence and extent of human alterations in the natural abundance of rare earth elements. This work presents the study of REE contents in fine-grained sediments of the (bedrock) Miño River, in an urban reach of its middle course. Different statistical procedures were employed in order to decipher the abundances and patterns of distribution of REE in different environments, showing a higher REE accumulation in surface sediments trapped by potholes and other rock cavities. Background contents were estimated by iterative simple regression. After checking several possible reference elements, Y showed the highest potential for the series of REE from La to Lu. The regression result, namely background function, is very useful to minimize the effect of the natural variability in sediment contents. Background functions also allow for environmental assessment by the calculation of the so-called local enrichment factors. As a general conclusion, contamination, if it exists, is negligible in the area and low enrichments can be attributed to postdepositional processes related to organic matter and the geochemistry of Fe and Mn.
Efficiency of Gum Rosin-Coated Personal Protective Clothing to Protect against Chlorpyrifos Exposure in Applicators
Authors: Sapbamrer Ratana , Naksata Manoch , Hongsibsong Surat , Chittrakul Jiraporn , Chaiut Wilawan
Published: February 2022

An ideal theoretical model for personal protective clothing (PPC) is to protect wearers from external workplace hazards while meeting certain ergonomic requirements. This study aims to compare the efficiency of different personal protective clothing in its protection against chlorpyrifos, including gum rosin-coated PPC, commercial PPC (Tychem® coverall), and everyday clothing, during application under field conditions. Perception of discomfort and physiological effects after wearing PPC were also investigated. Thirty-one applicators were invited and consented to participate in the study. The study established that the median percentage of chlorpyrifos protection efficiency was 90.7% for commercial PPC, 89.2% for gum rosin-coated PPC, and 76.5% for everyday PPC. When the protection efficiency was compared among the different types of PPC, the percentage protection efficiency of gum rosin-coated PPC was not significantly different from that of commercial PPC. The percentage protection efficiencies of commercial PPC and gum rosin-coated PPC were significantly higher than that of everyday PPC. The major characteristics of gum rosin-coated PPC were water-repellency, breathability, low cost, and ease of manufacture. Therefore, this study suggests that gum rosin-coated PPC is a reasonable alternative PPC for farmers, particularly in low and middle-low-income countries and tropical climates, to protect against pesticides while providing acceptable comfort.
Fixed-Bed Adsorption of Lead from Aqueous Solution Using Chitosan-Coated Bentonite
Authors: Futalan Cybelle Morales , Wan Meng-Wei
Published: February 2022

In this study, fixed-bed adsorption of Pb(II) from an aqueous solution using chitosan-coated bentonite (CCB) was investigated. Characterization of CCB was performed using Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The effects of varying bed height (1.3 to 4.3 cm), flow rate (0.20 to 0.60 mL/min), and initial concentration (500 to 1500 mg/L) on the length of mass transfer zone (Zm) and adsorption capacity at breakthrough (qb) and exhaustion (qe) were examined. Low flow rate and high bed height were determined to cause a longer time to reach breakthrough and exhaustion. Meanwhile, the fixed-bed system was observed to quickly attain breakthrough and exhaustion under high initial concentrations. Kinetic column models such as the Thomas, Yoon–Nelson, and Clark models were used to predict the breakthrough curves. High R2 values (0.9758 ≤ R2 ≤ 0.8087) were attained for the Thomas model, which indicates that there is good agreement between experimental data and linear plots generated by the Thomas model. Moreover, the Thomas model is best in describing the breakthrough curves of Pb(II) removal under a fixed-bed system.
Effect of TOC Concentration of Humic Substances as an Electron Shuttle on Redox Functional Groups Stimulating Microbial Cr(VI) Reduction
Authors: Zhou Yi , Duan Jingtao , Jiang Jie , Yang Zhen
Published: February 2022

Humic substances as an electron shuttle play an essential role in the biogeochemistry processes. However, the influence of total organic carbon (TOC) concentrations of humic substances on microbial Cr(VI) reduction remains unclear. In this study, the rates and extents of Cr(VI) reduction by Shewanella oneidensis MR-1 in the presence of Leonardite humic acids (LHA) and Pahokee peat humic acids (PPHA) with different TOC concentrations were evaluated. We found that the enhanced reduction in Cr(VI) was associated with TOC concentrations of 2.5–50 mg C/L of HA samples. The result shows that HA as an electron shuttle impacted both rates and extents of microbial Cr (VI) reduction, which delivered differently in terms of low TOC concentration range of 2.5 to 15 mg C/L and high concentration range of 15–50 mg C/L. The rates of Cr(VI) reduction significantly enhanced in the low TOC concentration range of HA compared to a high concentration range. The highest acceleration rate of Cr(VI) reduction was achieved at 15 mg C/L of HA. The quinone-like fluorophore was responsible for the main redox-active functional groups of HA by the three-dimensional excitation-emission spectroscopy. The fluorescence intensity of quinone-like fluorophore of HA in the low TOC concentration range was positively correlated with its acceleration coefficient, corresponding to the highest microbial Cr(VI) reduction rate obtained in 15 mg C/L of HA. These findings highlighted the effect of the TOC concentration of HA on microbial Cr(VI) reduction processes. It emphasized that the low TOC concentration of HA contributed to the high rates of Cr(VI) reduction, which is critical for better understanding the fate of Cr(VI) and evaluating the effectiveness of Cr(VI) restoration strategies in the future.