bluuebunny/crossref_metadata_2025 huggingface dataset:
Martensitic Transition, Magnetic, Microstructural and Exchange Bias Properties of Melt Spun Ribbons of Mn-Ni-Sn Shape Memory Heusler Alloy
Authors: Sharma Jyoti , Suresh K. G. , Raja M. Manivel , Walke Pravin
Published: May 2024

In the present report, we have studied the structural, microstructural, magnetic, exchange bias (EB) properties and magnetoresistance (MR) in Mn rich (Mn at. ∼50%) Mn50Ni50−xSnx (x = 10) shape memory Heusler alloy ribbons, prepared using the melt spinning method. These ribbons were found to exhibit a first order structural (i.e., martensitic) transition at around 205 K from the high temperature austenite to the low temperature martensite phase. The martensitic transition occurs at comparatively lower temperatures in these ribbons than in the same bulk alloy. Curie temperature of the austenite phase (TCA) is found to be larger i.e., around room temperature than that of bulk alloy. A significant EB field (HEB) of around 960 Oe has been observed at 2 K for these ribbons, which is found to be comparable to that reported for other Heusler systems. The presence of the EB effect in these ribbons is attributed to the coexistence of FM/AFM exchange interactions in the martensite phase. They are also found to show a maximum negative MR of around 12% near the martensitic transition, for 50 kOe field change. Investigation of DC magnetization, AC susceptibility measurements and the observation of training effect (i.e., characteristic feature of EB) strongly corroborates with the coexistence of FM/AFM exchange interactions in the martensite phase of these ribbons, which results in the large EB. The effects of temperature and magnetic field on the EB properties and MR have also been studied here.
A retrospective study of 68Ga-FAPI PET/CT in differentiating the nature of pulmonary lesions
Authors: Xie Yang , Tang Wenxin , Ma Jiao , Chen Yue
Published: May 2024

Purpose

This study aimed to investigate the characteristics of various pulmonary lesions as revealed by 68Ga-FAPI PET/CT and to determine the utility of 68Ga-FAPI PET/CT in distinguishing the nature of these pulmonary lesions.

Methods

A retrospective analysis was conducted on 99 patients with pulmonary lesions, who were categorized into three distinct groups: primary lung tumors (G1), metastatic lung tumors (G2), and benign lesions (G3). Each participant underwent a 68Ga-FAPI PET/CT scan. Among these groups, variables such as the Tumor/Background Ratio (TBR), Maximum Standardized Uptake Value (SUVmax), and the true positive rate of the lesions were compared. Furthermore, the FAPI uptake in nodular-like pulmonary lesions (d<3cm) and those with irregular borders was evaluated across the groups. A correlation analysis sought to understand the relationship between FAPI uptake in primary and pulmonary metastatic lesions.

Results

The study’s participants were composed of 52 males and 47 females, with an average age of 56.8 ± 13.2 years. A higher uptake and detection rate for pulmonary lesions were exhibited by Group G1 compared to the other groups (SUVmax [G1 vs. G2 vs. G3: 9.1 ± 4.1 vs. 6.1 ± 4.1 vs. 5.3 ± 5.8], P<0.05; TBR [G1 vs. G2 vs. G3: 6.2 ± 2.4 vs. 4.1 ± 2.2 vs. 3.2 ± 2.7], P<0.01; true positive rate 95.1% vs. 88% vs. 75.6%]. In nodular-like lung lesions smaller than 3 cm, G1 showed a significantly higher FAPI uptake compared to G2 and G3 (SUVmax [G1 vs. G2 vs. G3: 8.8 ± 4.3 vs. 5.2 ± 3.2 vs. 4.9 ± 6.1], P<0.01; TBR [G1 vs. G2 vs. G3: 5.7 ± 2.7 vs. 3.7 ± 2.1 vs. 3.3 ± 4.4], P<0.05). Both G1 and G2 demonstrated significantly elevated FAPI agent activity in irregular-bordered pulmonary lesions when compared to G3 (SUVmax [G1 vs. G2 vs. G3: 10.9 ± 3.3 vs. 8.5 ± 2.7 vs. 4.6 ± 2.7], P<0.01; TBR [G1 vs. G2 vs. G3: 7.2 ± 2.1 vs. 6.4 ± 1.3 vs. 3.2 ± 2.4], P<0.01). A positive correlation was identified between the level of 68Ga-FAPI uptake in primary lesions and the uptake in pulmonary metastatic lesions within G2 (r=0.856, P<0.05).

Conclusion

68Ga-FAPI PET/CT imaging proves to be of significant value in the evaluation of pulmonary lesions, offering distinctive insights into their nature.
Drug repositioning in thyroid cancer: from point mutations to gene fusions
Authors: Sánchez-Marín David , Silva-Cázares Macrina Beatriz , González-Del Carmen Manuel , Campos-Parra Alma D.
Published: May 2024

The diagnosis of thyroid cancer (TC) has increased dramatically in recent years. Papillary TC is the most frequent type and has shown a good prognosis. Conventional treatments for TC are surgery, hormonal therapy, radioactive iodine, chemotherapy, and targeted therapy. However, resistance to treatments is well documented in almost 20% of all cases. Genomic sequencing has provided valuable information to help identify variants that hinder the success of chemotherapy as well as to determine which of those represent potentially druggable targets. There is a plethora of targeted therapies for cancer, most of them directed toward point mutations; however, chromosomal rearrangements that generate fusion genes are becoming relevant in cancer but have been less explored in TC. Therefore, it is relevant to identify new potential inhibitors for genes that are recurrent in the formation of gene fusions. In this review, we focus on describing potentially druggable variants and propose both point variants and fusion genes as targets for drug repositioning in TC.
Predicting the geographical distribution and niche characteristics of Cotoneaster multiflorus based on future climate change
Authors: Huang Qiuliang , Liu Haoyang , Li Changshun , Zhu Xiaoru , Yuan Zongsheng , Lai Jialiang , Cao Minghui , Huang Zhenbei , Yang Yushan , Zhuo Shenglan , Lü Zengwei , Zhang Guofang
Published: May 2024

Introduction

Arid and semi-arid regions are climate-sensitive areas, which account for about 40% of the world’s land surface area. Future environment change will impact the environment of these area, resulting in a sharp expansion of arid and semi-arid regions. Cotoneaster multiflorus is a multi-functional tree species with extreme cold, drought and barren resistance, as well as ornamental and medicinal functions. It was found to be one of the most important tree species for ecological restoration in arid and semi-arid areas. However, bioclimatic factors play an important role in the growth, development and distribution of plants. Therefore, exploring the response pattern and ecological adaptability of C. multiflorus to future climate change is important for the long-term ecological restoration of C. multiflorus in arid and semi-arid areas.

Methods

In this study, we predicted the potential distribution of C. multiflorus in China under different climate scenarios based on the MaxEnt 2.0 model, and discussed its adaptability and the major factors affecting its geographical distribution.

Results

The major factors that explained the geographical distribution of C. multiflorus were Annual precipitation (Bio12), Min air temperature of the coldest month (Bio6), and Mean air temperature of the coldest quarter (Bio11). However, C. multiflorus could thrive in environments where Annual precipitation (Bio12) >150 mm, Min air temperature of the coldest month (Bio6) > -42.5°C, and Mean air temperature of the coldest quarter (Bio11) > -20°C, showcasing its characteristics of cold and drought tolerance. Under different future climate scenarios, the total suitable area for C. multiflorus ranged from 411.199×104 km² to 470.191×104 km², which was 0.8~6.14 percentage points higher than the current total suitable area. Additionally, it would further shift towards higher latitude.

Discussion

The MaxEnt 2.0 model predicted the potential distribution pattern of C. multiflorus in the context of future climate change, and identified its ecological adaptability and the main climatic factors affecting its distribution. This study provides an important theoretical basis for natural vegetation restoration in arid and semi-arid areas.
Plant virus transmission during seed development and implications to plant defense system
Authors: Escalante Cesar , Sanz-Saez Alvaro , Jacobson Alana , Otulak-Kozieł Katarzyna , Kozieł Edmund , Balkcom Kipling S. , Zhao Chaoyang , Conner Kassie
Published: May 2024

Most plants produce large amounts of seeds to disperse their progeny in the environment. Plant viruses have evolved to avoid plant resistance mechanisms and use seeds for their dispersal. The presence of plant pathogenic viruses in seeds and suppression of plant host defenses is a major worldwide concern for producers and seed companies because undetected viruses in the seed can represent a significant threat to yield in many economically important crops. The vertical transmission of plant viruses occurs directly through the embryo or indirectly by getting in pollen grains or ovules. Infection of plant viruses during the early development of the seed embryo can result in morphological or genetic changes that cause poor seed quality and, more importantly, low yields due to the partial or ubiquitous presence of the virus at the earliest stages of seedling development. Understanding transmission of plant viruses and the ability to avoid plant defense mechanisms during seed embryo development will help identify primary inoculum sources, reduce virus spread, decrease severity of negative effects on plant health and productivity, and facilitate the future of plant disease management during seed development in many crops. In this article, we provide an overview of the current knowledge and understanding of plant virus transmission during seed embryo development, including the context of host-virus interaction.
Mentalization-based approach for schizophrenia spectrum disorders: a psychotherapeutic proposal for evolved schizophrenic trajectories and serious mental disorders
Authors: Sanz Pedro , Tur Nuria , Lana Fernando
Published: May 2024

There is a growing interest in psychotherapeutic approaches to pre-psychotic high-risk states or first-episode psychosis, where mentalization-based treatment has shown its utility. This article presents a mentalization-based approach for the treatment of those individuals diagnosed with an evolved schizophrenia spectrum disorder, whose characteristics make them especially inaccessible to reflective psychotherapeutic treatment. A synthesis of the conceptual frameworks that justify the needs for technical modification of the mentalization-based treatment foundational techniques is carried out, followed by the proposal of adaptations, with a focus in self-agency and patient-therapist dyad. Therapeutic interventions are outlined, including illustrative examples. The mentalizing approach presented here holds promise for future research and treatment opportunities for patients with evolved schizophrenia and other serious mental disorders.
Mycobactin analogue interacting with siderophore efflux-pump protein: insights from molecular dynamics simulations and whole-cell assays
Authors: Shyam Mousumi , Thakur Abhishek , Velez Caroline , Daniel Chris , Acevedo Orlando , Bhakta Sanjib , Jayaprakash Venkatesan
Published: May 2024

Introduction

In response to continued public health emergency of antimicrobial resistance (AMR), a significant key strategy is the discovery of novel mycobacterial efflux-pump inhibitors (EPIs) as potential adjuvants in combination drug therapy. Interest in identifying new chemotypes which could potentially synergize with the existing antibiotics and can be deployed as part of a combination therapy. This strategy could delay the emergence of resistance to existing antibiotics and increase their efficacy against resistant strains of mycobacterial species. In recent decades, notable approaches have been accounted for EPI development and have resulted in the discovery of several EPIs including SQ109 and AU1235. In context, to accelerate newer EPIs with novel mode of action here we have discussed mycobactin analogues and highlighted in silico binding orientation with siderophore efflux-pump proteins MmpL4/5.

Methods

3-(2-hydroxyphenyl)-5-(aryl)-pyrazoline series was investigated for whole-cell efflux-pump inhibitory activity against Mycobacterium smegmatis and Mycobacterium abscessus. Machine learning and molecular dynamics were performed to construct a MmpL4/5 complex embedded in a lipid bilayer to identify the putative binding site and to predict ligand-protein binding energetics. Furthermore, the identified HIT compound was investigated in synergistic assay with bedaquiline.

Results

Compound Il, 2-(5-(4-fluorophenyl)-4,5-dihydro-1H-pyrazol-3-yl)phenol, was identified as the most potent efflux pump inhibitor against M. smegmatis in whole-cell efflux-pump investigation. Followed HIT Il employed against M. abscessus for efflux-pump inhibition investigations and notable whole-cell efflux-pump inhibitory profile has been observed. The theoretical investigations predicted compound Il to be selective towards MmpL4, with significant hydrogen bonding and π-π stacking interactions effectively blocking a critical Asp-Tyr dyad interaction network necessary for proton translocation. Compound Il with bedaquiline highlighted an additive profile against the M. abscessus pathogen.

Conclusions

MD simulations and whole-cell assays are indicating potential development of compound Il as an adjunct to the existing therapeutic regimen against mycobacterial infections.
AL amyloidosis: an overview on diagnosis, staging system, and treatment
Authors: Morè Sonia , Manieri Valentina Maria , Corvatta Laura , Morsia Erika , Poloni Antonella , Offidani Massimo
Published: May 2024

Systemic light-chain (AL) amyloidosis is a monoclonal plasma cell disease characterized by the deposition of amyloidogenic monoclonal light-chain fragments in organs, causing their dysfunction. Clinical manifestations could be very aspecific, but the most frequent ones are proteinuria with or without renal failure or heart failure, with the kidney and the heart being the first two involved organs. Histological diagnosis with Congo red staining is the gold standard, but typing the amyloid with immunohistochemistry or mass spectrometry of the Congo red positive tissue is necessary to establish if an AL or ATTR amyloidosis could be diagnosed. Staging AL amyloidosis before treatment could help physicians to prognosticate the disease. Recently, staging systems were set separately for different involved organs, using biomarkers. Autologous stem cell transplant after a daratumumab-based induction treatment is the cornerstone of therapy in younger and fit patients, with the goal of reaching a deep and rapid disease hematological and organ response. Novel therapies, borrowed from a therapeutical model of multiple myeloma, are studied to optimize AL amyloidosis outcomes. In this review, we make an overview of diagnostic procedures, staging system, and therapies of AL amyloidosis.
Exploring the Impact of Pandemic Measures on Airport Performance
Authors: Liou James J. H. , Chien Chih Wei , Gudiel Pineda Pedro Jose , Li Chun-Sheng Joseph , Hsu Chao-Che
Published: May 2024

The impact of COVID-19 measures on airport performance is obvious, and there have been numerous studies on this topic. However, most of these studies discuss prevention measures, the effects on airport operations, forecasts of economic impacts, changes in service quality, etc. There is a lack of research on the effects of various prevention measures on airport operations and the interrelationships between these measures. This study focuses on addressing this gap. In this study, an integrated approach is devised that combines the decision-making trial and evaluation laboratory (DEMATEL) method and interpretive structural modeling (ISM). This integrated method is useful for exploring the relationship between pandemic measures and airport performance as well as the complex relationship between them, and the combination of methods improves upon the shortcomings of the original models. This study reveals that mandating vaccination certificates for entry into a country is the most significant measure affecting airport performance. Additionally, aircraft movement at the airport has the greatest overall impact and can be considered the most crucial factor influencing airport performance from an operational standpoint. The findings show that both factors directly influence financial performance, as reflected in the net income. Some management implications are provided to mitigate the consequences of the measures taken to counter the pandemic crisis. This integrated approach should also assist authorities and policy-makers in planning cautious action for future crises.
Brucella Manipulates Host Cell Ferroptosis to Facilitate Its Intracellular Replication and Egress in RAW264.7 Macrophages
Authors: Zhang Guangdong , Hu Hai , Yin Yi , Tian Mingxing , Bu Zhigao , Ding Chan , Yu Shengqing
Published: May 2024

Brucella virulence relies on its successful intracellular life cycle. Modulating host cell death is a strategy for Brucella to survive and replicate intracellularly. Ferroptosis is a novel regulated cell death characterized by iron-triggered excessive lipid peroxidation, which has been proven to be associated with pathogenic bacteria infection. Thus, we attempted to explore if smooth-type Brucella infection triggers host cell ferroptosis and what role it plays in Brucella infection. We assessed the effects of Brucella infection on the lactate dehydrogenase release and lipid peroxidation levels of RAW264.7 macrophages; subsequently, we determined the effect of Brucella infection on the expressions of ferroptosis defense pathways. Furthermore, we determined the role of host cell ferroptosis in the intracellular replication and egress of Brucella. The results demonstrated that Brucella M5 could induce ferroptosis of macrophages by inhibiting the GPX4-GSH axis at the late stage of infection but mitigated ferroptosis by up-regulating the GCH1-BH4 axis at the early infection stage. Moreover, elevating host cell ferroptosis decreased Brucella intracellular survival and suppressing host cell ferroptosis increased Brucella intracellular replication and egress. Collectively, Brucella may manipulate host cell ferroptosis to facilitate its intracellular replication and egress, extending our knowledge about the underlying mechanism of how Brucella completes its intracellular life cycle.
Electrode Blending Simulations Using the Mechanistic Degradation Modes Modeling Approach
Authors: Beck David , Dubarry Matthieu
Published: May 2024

Blended electrodes are becoming increasingly more popular in lithium-ion batteries, yet most modeling approaches are still lacking the ability to separate the blend components. This is problematic because the different components are unlikely to degrade at the same pace. This work investigated a new approach towards the simulation of blended electrodes by replicating the complex current distributions within the electrodes using a paralleling model rather than the traditional constant-current method. In addition, a blending model was used to generate three publicly available datasets with more than 260,000 unique degradations for three exemplary blended cells. These datasets allowed us to showcase the necessity of considering all active components of the blend separately for diagnosis and prognosis.
Sleep-Disordered Breathing, Advanced Age, and Diabetes Mellitus Are Associated with De Novo Atrial Fibrillation after Cardiac Surgery
Authors: Tafelmeier Maria , Kuettner Sabrina , Hauck Christian , Floerchinger Bernhard , Camboni Daniele , Creutzenberg Marcus , Zeman Florian , Schmid Christof , Maier Lars Siegfried , Wagner Stefan , Arzt Michael
Published: May 2024

Background: Postoperative de novo atrial fibrillation (POAF) is one of the most frequently encountered complications following cardiac surgery. Despite the identification of several risk factors, the link between sleep-disordered breathing (SDB) and POAF has barely been examined. The objective of this prospective observational study was to determine whether severe SDB is associated with POAF in patients after elective coronary artery bypass grafting (CABG) surgery. Study design and methods: The incidence and preoperative predictors of in-hospital POAF were assessed in 272 patients undergoing CABG surgery at the University Medical Center Regensburg (Germany). In-hospital POAF was detected by continuous telemetry-ECG monitoring and 12-lead resting ECGs within the first seven postoperative days. POAF that occurred after hospital discharge within 60 days post CABG surgery was classified as post-hospital POAF and was ascertained by standardized phone interviews together with the patients’ medical files, including routinely performed Holter-ECG monitoring at 60 days post CABG surgery. The night before surgery, portable SDB monitoring was used to assess the presence and type of severe SDB, defined by an apnea–hypopnea index ≥ 30/h. Results: The incidence of in-hospital POAF was significantly higher in patients with severe SDB compared to those without severe SDB (30% vs. 15%, p = 0.009). Patients with severe SDB suffered significantly more often from POAF at 60 days post CABG surgery compared to patients without severe SDB (14% vs. 5%, p = 0.042). Multivariable logistic regression analysis showed that severe SDB (odds ratio, OR [95% confidence interval, CI]: 2.23 [1.08; 4.61], p = 0.030), age ≥ 65 years (2.17 [1.04; 4.53], p = 0.038), and diabetes mellitus (2.27 [1.15; 4.48], p = 0.018) were significantly associated with in-hospital POAF. After additional adjustment for heart failure, the association between sleep apnea and postoperative atrial fibrillation was attenuated (1.99 [0.92; 4.31], p = 0.081). Conclusions: Amongst established risk factors, severe SDB was significantly associated with in-hospital POAF in patients undergoing CABG surgery. Whether SDB contributes to POAF independently of heart failure and whether risk for POAF may be alleviated by proper treatment of SDB merits further investigation.
The Association between Urine N-Glycome and Prognosis after Initial Therapy for Primary Prostate Cancer
Authors: Vermassen Tijl , Lumen Nicolaas , Van Praet Charles , Callewaert Nico , Delanghe Joris , Rottey Sylvie
Published: May 2024

Next to prostate-specific antigen, no biochemical biomarkers have been implemented to guide patient follow-up after primary therapy for localized prostate cancer (PCa). We evaluated the prognostic potential of urine N-glycome in terms of event-free survival (EFS) in patients undergoing primary therapy for PCa. The prognostic features of the urine N-glycosylation profile at diagnosis, assessed in 77 PCa patients, were determined in terms of EFS next to standard clinical parameters. The majority of patients were diagnosed with International Society of Urological Pathology grade ≤ 3 (82%) T1–2 tumors (79%) and without pelvic lymph node invasion (96%). The patients underwent active surveillance (14%), robot-assisted laparoscopic prostatectomy (48%), or external beam radiotherapy (37%). Decreased ratios of biantennary core-fucosylation were noted in patients who developed an event, which was linked to a shorter EFS in both the intention-to-treat cohort and all subcohort analyses. Combining the urine N-glycan biomarker with the D’Amico Risk Classification for PCa resulted in an improved nomogram for patient classification after primary therapy. The rate of urine N-glycan biantennary core-fucosylation, typically linked to more aggressive disease status, is lower in patients who eventually developed an event following primary therapy and subsequently in patients with a worse EFS. The combination of urine N-glycan biomarkers together with clinical parameters could, therefore, improve the post-therapy follow-up of patients with PCa.
Gate-Tunable Asymmetric Quantum Dots in Graphene-Based Heterostructures: Pure Valley Polarization and Confinement
Authors: Belayadi Adel , Vasilopoulos Panagiotis
Published: May 2024

We explore the possibility of attaining valley-dependent tunnelling and confinement using proximity-induced spin-orbit couplings (SOCs) in graphene-based heterostructures. We consider gate-tunable asymmetric quantum dots (AQDs) on graphene heterostructures and exhibiting a C3v and/or C6v symmetry. By employing a tight-binding model, we explicitly reveal a pure valley confinement and valley signal in AQDs by streaming the valley local density, leading to valley-charge separation in real space. The confinement of the valley quasi-bound states is sensitive to the locally induced SOCs and to the spatial distribution of the induced AQDs; it is also robust against on-site disorder. The adopted process of attaining a pure valley-Hall conductivity and confinement with zero charge currents is expected to provide more options towards valley-dependent electron optics.
The Role of FKBPs in Complex Disorders: Neuropsychiatric Diseases, Cancer, and Type 2 Diabetes Mellitus
Authors: Agam Galila , Atawna Bayan , Damri Odeya , Azab Abed N.
Published: May 2024

Stress is a common denominator of complex disorders and the FK-506 binding protein (FKBP)51 plays a central role in stress. Hence, it is not surprising that multiple studies imply the involvement of the FKBP51 protein and/or its coding gene, FKBP5, in complex disorders. This review summarizes such reports concentrating on three disorder clusters—neuropsychiatric, cancer, and type 2 diabetes mellitus (T2DM). We also attempt to point to potential mechanisms suggested to mediate the effect of FKBP5/FKBP51 on these disorders. Neuropsychiatric diseases considered in this paper include (i) Huntington’s disease for which increased autophagic cellular clearance mechanisms related to decreased FKBP51 protein levels or activity is discussed, Alzheimer’s disease for which increased FKBP51 activity has been shown to induce Tau phosphorylation and aggregation, and Parkinson’s disease in the context of which FKBP12 is mentioned; and (ii) mental disorders, for which significant association with the single nucleotide polymorphism (SNP) rs1360780 of FKBP5 intron 7 along with decreased DNA methylation were revealed. Since cancer is a large group of diseases that can start in almost any organ or tissue of the body, FKBP51’s role depends on the tissue type and differences among pathways expressed in those tumors. The FKBP51–heat-shock protein-(Hsp)90–p23 super-chaperone complex might function as an oncogene or as a tumor suppressor by downregulating the serine/threonine protein kinase (AKt) pathway. In T2DM, two potential pathways for the involvement of FKBP51 are highlighted as affecting the pathogenesis of the disease—the peroxisome proliferator-activated receptor-γ (PPARγ) and AKt.
Prevalence of Obesity and Dental Caries in High School Adolescents during the First Decade of Saudi Vision 2030: A Cross-Sectional Study
Authors: Farsi Deema J. , Farsi Nada J. , Elkhodary Heba M. , Alattas Logain K. , Alshaikh Ali B. , Farsi Najat M.
Published: May 2024

Saudi Vision 2030 was launched in 2016. Obesity and dental caries are both highly prevalent in Saudi adolescents and have been targeted by the Vision’s health initiatives. The aim is to assess their prevalence in adolescents during the first decade since the launch of the Vision. This cross-sectional study was conducted in Jeddah, Saudi Arabia using a stratified sample of 571 high school students, with an average age of 16.7 (0.6). Their height and weight were measured, and their body mass index (BMI) was calculated. The decayed, missed, and filled scores (DMFTs) were recorded after an oral examination. Non-parametric tests were used to assess the associations of DMFT with BMI, sex, and school type; and its predictors were assessed. One-third of males were overweight/obese compared with 22% of females. Males exhibited higher DMFTs than females. DMFTs were higher among public school students than among their private school counterparts. No significant association was observed between DMFT and BMI. Sex and school type were significant predictors of DMFT. The prevalence of obesity has slowly decreased in adolescents, but the prevalence of dental caries has not. There was no significant relationship between these conditions. Saudi Vision 2030’s current preventive/educational initiatives may be more effective in combating obesity than dental caries.
Shedding Light on Pediatric Fractures: Bridging the Knowledge Gap
Authors: van Bergen Christiaan J. A. , Colaris Joost W.
Published: May 2024

After the great success of the printed edition of the Special Issue “Pediatric Fractures—Volume I”, which was published in 2023 containing 24 high-quality papers [...]
Investigating the Effects of the COVID-19 Pandemic on Stock Volatility in Sub-Saharan Africa: Analysis Using Explainable Artificial Intelligence
Authors: Ncube Mbongiseni , Sibanda Mabutho , Matenda Frank Ranganai
Published: May 2024

This study examines the impact of the COVID-19 pandemic on sector volatility in sub-Saharan Africa by drawing evidence from two large and two small stock exchanges in the region. The analysis included stock-specific data, COVID-19 metrics, and macroeconomic indicators from January 2019 to July 2022. This study employs generalized autoregressive conditional heteroskedasticity (GARCH) models to estimate volatility and Explainable Artificial Intelligence (XAI) in the form of SHapley Additive exPlanations (SHAP) to identify significant factors driving stock volatility during the pandemic. The findings reveal significant volatility increases at the onset of the pandemic, with government stringency measures leading to increased volatility in larger exchanges, while the introduction of vaccination programs helped to reduce volatility. Weaker macroeconomic fundamentals impact volatility in smaller exchanges. The healthcare sector has emerged as the most resilient, while non-essential sectors, such as consumer discretionary, materials, and real estate, face greater vulnerability, especially in smaller exchanges. The research findings reveal that the heightened stock market volatility observed was mainly a result of the government’s actions to combat the spread of the pandemic, rather than its outbreak. We recommend that governments introduce sound policies to balance public health measures and economic stability, and that investors diversify their investments to reduce the impact of pandemics.
Screening and In Silico Analyses of the Yeast Saccharomyces cerevisiae Σ1278b Bank Mutants Using Citral as a Natural Antimicrobial
Authors: El Harati Rolla , Fancello Francesco , Multineddu Chiara , Zara Giacomo , Zara Severino
Published: May 2024

The antimicrobial function of citral, one of the main compounds of the essential oils (EO) of the Citrus genus, and widely used by the food industry toward spoilage yeast, was previously proven. In this study, the possible mode of action of citral against yeast cells was evaluated by using a global deletome approach. Firstly, the suitability of Saccharomyces cerevisiae Σ1278b to serve as model yeast was assessed by determining its sensitivity to citral (MIC = 0.5 μL/mL). Subsequently, the complete library of Σ1278b haploid mutants deleted in 4019 non-essential genes was screened to identify potential molecular targets of citral. Finally, the deleted genes in the 590 mutants showing increased citral resistance was analyzed with an in-silico approach (Gene Ontology). The significantly enriched GO Terms were “cytoplasm”, “vacuole”, and “mitochondrion” (cellular components); “catalytic activity” (molecular function); “pseudohyphal growth” (biological process). For molecular function, resistant mutants were grouped into thiosulfate sulfur transferase activity, transferase activity, and oxidoreductase activity; for cellular components, resistant mutants were grouped as: cytoplasm, intracellular organelle, membrane-bounded organelle, mitochondrion, organelle membrane, and vacuole; and finally, with regard to biological process, deleted genes were grouped as: pseudohyphal growth, mitochondrion organization, lipid metabolic process, DNA recombination and repair, and proteolysis. Interestingly, many identified genes were associated with the cellular response to oxidative stress and ROS scavenging. These findings have important implications for the development of citral-based antimicrobials and the elucidation of its mechanism of action.
Associations between Fluid Intelligence and Physical Fitness in School Children
Authors: Bazalo Borja , Morales-Sánchez Verónica , Pérez-Romero Nuria , Contreras-Osorio Falonn , Campos-Jara Christian , Hernández-Mendo Antonio , Reigal Rafael E.
Published: May 2024

Previous research has highlighted that active lifestyles that contribute to improved physical fitness are positively related to cognitive functioning in children and adolescents. Specifically, the increase in physical condition at school age is considered relevant because it is related to better cognitive ability and greater academic performance. Thus, the aim of this study was to analyze the relationships between explosive strength, speed–agility, and fluid reasoning in schoolchildren. To achieve this objective, an associative, comparative, and predictive design was used in this research. A total of 129 children participated in this study (age: M = 9.48; SD = 0.99). To assess fluid reasoning, the Raven test’s Standard Progressive Matrices Subtest and the Wechsler Intelligence Scale for Children (WISC-V) were used. To assess physical fitness, the speed–agility test and the horizontal jump test (ALPHA-fitness battery tests), as well as the ball throw test (2 kg), were used. The results showed that the speed–agility test significantly predicted WISC-V Fluid Reasoning Index scores, and the medicine ball toss test significantly predicted Raven test scores. The results obtained highlight the associations between physical condition at these ages and fluid intelligence. This suggests that promoting active lifestyles that improve physical fitness could have a positive impact on children’s cognitive health.
Inflatable Penile Prosthesis Complication in the Emergency Department
Authors: Sedaghat Farzad , Kamona Aws
Published: May 2024

Inflatable penile prostheses are a widely utilized treatment for erectile dysfunction. While MRI is the optimal imaging modality for patients with suspected implant complications, it is often unavailable in the acute setting. In light of these limitations, we present a case of urethral perforation by an implanted penile cylinder and its evaluation with contrast-enhanced computed tomography (CT) in an emergent setting.
Adapting and Evaluating a Theory-Driven, Non-Pharmacological Intervention to Self-Manage Pain
Authors: Kawi Jennifer , Yeh Chao Hsing , Grant Lauren , Thrul Johannes , Wu Hulin , Christo Paul J. , Evangelista Lorraine S.
Published: May 2024

Background: The existing literature has limited detail on theory-driven interventions, particularly in pain studies. We adapted Bandura’s self-efficacy framework toward a theory-driven, non-pharmacological intervention using auricular point acupressure (APA) and evaluated participants’ perceptions of this intervention on their pain self-management. APA is a non-invasive modality based on auricular acupuncture principles. Methods: We mapped our study intervention components according to Bandura’s key sources of self-efficacy (performance accomplishments, vicarious experience, verbal persuasion, and emotional arousal) to facilitate the self-management of pain. Through a qualitative study design, we conducted virtual interviews at one and three months after a 4-week APA intervention among 23 participants using purposive sampling to describe their experiences in managing their pain based on our theory-driven APA intervention. Results: Using thematic analyses, we found four themes: the enhanced self-management of pain, improved pain outcomes, the feasibility of technology, and the sustainability of APA. Conclusions: Describing how interventions are mapped according to the elements of theoretical frameworks can help to guide intervention development, advance science and knowledge development, and promote the implementation of interventions. As such, using Bandura’s self-efficacy theory as a foundation for the APA intervention, APA was found to be feasible and sustainable, improving self-management, pain intensity, and pain-related outcomes. Participants provided recommendations for the further improvement of this theory-driven intervention.
Telerehabilitation in Children and Adolescents with Cystic Fibrosis: A Scoping Review
Authors: Pessoa Ezequiel , Ferreira Mara , Baixinho Cristina Lavareda
Published: May 2024

Cystic fibrosis requires regular monitoring and intervention by healthcare teams; despite that, adherence to therapeutic measures is less than desired. The evolution of technology has allowed much of the care provided in person to be replaced by a telehealth delivery model, but studies on telerehabilitation are scarce and dispersed. This scoping review aimed to identify which domains of rehabilitation intervention are mediated by information and communication technologies and how they are developed in the provision of care to children and adolescents with cystic fibrosis. The data collection was conducted in February and June 2023, following the three steps recommended by the JBI for this type of review: (1) the search was conducted in MEDLINE, CINAHL, Scopus, JBI, and Web of Science; (2) the bibliographic references obtained from the included articles were analysed; and (3) the grey literature was checked. The eligibility criteria were children and adolescents and rehabilitation interventions mediated by information and communication technologies. The five studies included in this review were subjected to analysis, and a narrative synthesis of the results was carried out. The interventions identified included physical exercise programs (60%), management of the therapeutic regimen (40%), and symptom control (40%). The information and communication technologies were web-based platforms, video games, and telephones. The use of telerehabilitation included face-to-face meetings to ensure participants performed the exercises correctly, monitor their response to exercise, and teach them how to avoid risky situations during home workouts. In all studies, exercise sessions were supervised by the participants’ parents or caregivers.
Effect of Biotic Stress Due to Phyllophaga spp. on Antioxidant Compounds during Jicama Root (Pachyrhizus erosus) Development
Authors: Cuellar-Sánchez Verónica , Arreguín-Centeno José Honorato , González-Vázquez Marcela , Salgado-Cruz Ma. de la Paz , Farrera-Rebollo Reynold R. , Gutiérrez-López Gustavo F. , Calderón-Domínguez Georgina
Published: May 2024

The levels of different nutraceutical metabolites present in the jicama root were measured when subjecting the plant to induced biotic stress via infestation with Phyllophaga spp. (white grubs). The change in secondary metabolites on the stressed jicama roots (SJ), mostly antioxidants, was followed over 100, 140, and 180 days and compared against the non-infested control jicama (CJ). Our results show that infested (SJ) samples contained higher concentrations of tannins, flavonoids, and total phenols, measured using spectrophotometric methods, peaking at 140 days, and higher overall concentration of saponins. SJ samples showed higher DPPH inhibition, peaking at 100 days. Chlorogenic acid had the highest concentration among the phenolic compounds (7.47 mg g−1), followed by protocatechuic acid, both in SJ, which was possibly related to the lower observed concentrations of caffeic and ferulic acids. As for flavonoids, we observed a high concentration of rutin in CJ and a low concentration of pelargonidin and myricetin in SJ, possibly promoted via the dihydrokaempferol pathway. Taken together, these results show that Phyllophaga spp.-mediated biotic stress affects the concentrations of secondary metabolites in the different maturity stages in jicama, having an effect on its metabolic pathways, which presents an opportunity for the use of material such as agro-industrial waste.
A Preliminary Study on the Identification of Genes Involved in Lignification in the Endocarp of Bared-Nut Walnut (Juglans regia L.) in Xinjiang, China
Authors: Yu Shangqi , Fu Jiazhi , Ye Qian , Wu Pengyu , Bao Jianping , Hu Haifang , Guo Zhongzhong , Zhang Rui , Jin Qiang
Published: May 2024

This study focused on the “Xinlu” walnut and explored the molecular regulatory mechanism of lignin synthesis in the endocarp, aiming to explain the formation of bared-nut walnuts through morphological, metabolomic, and transcriptomic techniques. It was found that the synthesis of lignin, cellulose, p-coumaryl alcohol, and sinapyl alcohol was severely inhibited in the pulpy-hue (PUH) of the endocarp. We obtained 14 modules (gene sets) significantly correlated with the lignification factor (LIG) and 1548 hub genes. Additionally, we identified a MEplum3 module involved in endocarp lignin synthesis, primarily participating in phenylalanine biosynthesis and the lignin biosynthetic process. Meanwhile, we constructed a gene co-expression network for the MEplum3 module and identified a key hub gene for lignin synthesis—JrCAD10. Among the different tissues of “Xinlu”, the expression level of JrCAD10 in the scleritic-hue (SCH) was significantly higher than in other tissues, with a relative copy number (RCN) of 3.2. However, JrCAD10 expression was severely suppressed in the PUH. The suppression of JrCAD10 expression led to the inhibition of lignin monomer synthesis, which further resulted in inhibited lignin synthesis, thus forming the bared-nut walnut. Our findings provide new insights into understanding the regulation of lignin synthesis and offer a possible explanation for the formation of bared-nut walnuts.
Computational Study on Influence Factors and Vortical Structures in Static Drift Tests
Authors: Yang Chen , Zeng Ke , Chu Jilong , Bu Shuxia , Zhu Zhang
Published: May 2024

This paper conducted a computational study on the KCS benchmark model at static drift conditions. At the first instance, the roles played by the grid size, turbulence model, and time step are qualitatively and quantitatively analyzed with the orthogonal experimental method (OEM). After the verification of simulated results compared with experimental data in a Static Oblique Towing Test (OTT), hydrodynamic performance is obtained with the employment of the SST κ-ω turbulence model. The grid size is set as 0.07 m while the time step as 0.01 s. The characteristics of the wake field are illustrated in different forms, such as contours of the free surface, distribution of pressure and hydrodynamic forces, variation of turbulent kinetic energy (TKE), and so on. For a deep insight into the physical mechanisms of the asymmetrical flow field, the Detached Eddy Simulation (DES) method is also utilized to capture vortical structures occurring around the hull, in comparison with results obtained through the Reynolds Averaged Navier Stokes (RANS) model. With the aim of a hydrodynamic derivative estimation or detailed flow characteristics analysis, corresponding selections of the computational method are disparate.
Potential Environmental Reservoirs of Candida auris: A Systematic Review
Authors: Silva Isabel , Miranda Isabel M. , Costa-de-Oliveira Sofia
Published: May 2024

Candida auris, a multidrug-resistant yeast, poses significant challenges in healthcare settings worldwide. Understanding its environmental reservoirs is crucial for effective control strategies. This systematic review aimed to review the literature regarding the natural and environmental reservoirs of C. auris. Following the PRISMA guidelines, published studies until October 2023 were searched in three databases: PubMed, Web of Science, and Scopus. Information regarding the origin, sampling procedure, methods for laboratory identification, and antifungal susceptibility was collected and analyzed. Thirty-three studies published between 2016 and 2023 in 15 countries were included and analyzed. C. auris was detected in various environments, including wastewater treatment plants, hospital patient care surfaces, and natural environments such as salt marshes, sand, seawater, estuaries, apples, and dogs. Detection methods varied, with molecular techniques often used alongside culture. Susceptibility profiles revealed resistance patterns. Phylogenetic studies highlight the potential of environmental strains to influence clinical infections. Despite methodological heterogeneity, this review provides valuable information for future research and highlights the need for standardized sampling and detection protocols to mitigate C. auris transmission.
Arbuscular Mycorrhizal Fungi Diversity in Sophora japonica Rhizosphere at Different Altitudes and Lithologies
Authors: Yu Limin , Zhang Zhongfeng , Liu Peiyuan , Zhou Longwu , Tan Shuhui , Kuang Shitou
Published: May 2024

Arbuscular mycorrhizal fungi play a key role in mediating soil–plant relationships within karst ecosystems. Sophora japonica, a medicinal plant with anti-inflammatory and antitumor properties, is widely cultivated in karst areas of Guangxi, China. We considered limestone, dolomite, and sandstone at altitudes ranging from 100 to 800 m and employed Illumina sequencing to evaluate AMF diversity and identify the factors driving S. japonica rhizosphere AMF community changes. We showed that the increase in altitude increased S. japonica AMF colonization and the Shannon index. The colonization of limestone plots was higher than that of other lithology. In total, 3,096,236 sequences and 5767 OTUs were identified in S. japonica rhizosphere soil. Among these, 270 OTUs were defined at the genus level and divided into 7 genera and 35 species. Moreover, available nitrogen, soil organic matter, and available calcium content had a coupling effect and positive influence on AMF colonization and Shannon and Chao1 indices. Conversely, available phosphorus, available potassium, and available magnesium negatively affected AMF Shannon and Chao1 indices. Lithology, altitude, pH, and available phosphorus are important factors that affect the dynamics of AMF in the S. japonica rhizosphere.
Simplified Strategy for Trajectory Tracking Application of a Passive Suspension Rover-Type Mobile Robot
Authors: Diaz-Ortega Jheison Duvier , Gutiérrez-Frías Octavio , Aguirre-Anaya José Alejandro , Luviano-Juárez Alberto
Published: May 2024

In the present work, based on an approximate modelling of a rover-type robot and a proportional control law, a simplified trajectory tracking strategy for a passive suspension rover-type mobile robot was developed. This strategy achieves trajectory tracking and the autonomous displacement of a rover, of which its configuration involves complex kinematics and dynamics. All these lineaments reduce the complexity of the analysis, the number of electronic components to implement, the computational requirements and the energy consumption. The robotic system used is based on the Shrimp rover, which is a robot with a passive suspension that is capable of carrying out displacements over rough terrain. The tests were performed using numerical simulations with different desired trajectories, and also using experimental tests using a passive suspension rover-type mobile robot.