bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Congenital Cytomegalovirus Infection in Pregnant Women Admitted to a University Hospital in Istanbul
Authors: Ozdemir Evrim , Sarac Sivrikoz Tugba , Sarsar Kutay , Tureli Dilruba , Onel Mustafa , Demirci Mehmet , Yapar Gizem , Yurtseven Eray , Has Recep , Agacfidan Ali , Kirkoyun Uysal Hayriye
Published: March 2024

Cytomegalovirus (CMV) can cause serious complications in immunocompromised individuals and fetuses with congenital infections. These can include neurodevelopmental impairments and congenital abnormalities in newborns. This paper emphasizes the importance of concurrently evaluating ultrasonography findings and laboratory parameters in diagnosing congenital CMV infection. To examine the prenatal characteristics of CMV DNA-positive patients, we assessed serum and amniotic fluid from 141 pregnant women aged 19–45 years, each with fetal anomalies. ELISA and PCR tests, conducted in response to these amniocentesis findings, were performed at an average gestational age of 25 weeks. Serological tests revealed that all 141 women were CMV IgG-positive, and 2 (1.41%) had low-avidity CMV IgG, suggesting a recent infection. CMV DNA was detected in 17 (12.05%) amniotic fluid samples using quantitative PCR. Of these, 82% exhibited central nervous system abnormalities. Given that most infections in pregnant women are undetectable and indicators non-specific, diagnosing primary CMV in pregnant women using clinical findings alone is challenging. We contend that serological tests should not be the sole means of diagnosing congenital CMV infection during pregnancy.
Herpes Simplex Virus Bronchopneumonitis in Critically Ill Patients with Acute on Chronic Liver Failure: A Retrospective Analysis
Authors: Dibos Miriam , Triebelhorn Julian , Schneider Jochen , Rasch Sebastian , Schmid Roland M. , Lahmer Tobias , Mayr Ulrich
Published: March 2024

(1) Background: Critically ill patients are frequently diagnosed with pulmonary Herpes simplex virus-1 (HSV) reactivation, which then can lead to HSV bronchopneumonitis and is associated with higher mortality and longer mechanical ventilation. For the particular subgroup of critically ill patients with acute on chronic liver failure (ACLF), however, the impact of HSV reactivation is unknown. We investigated the impact of HSV reactivation in these patients. (2) Methods: We conducted a retrospective analysis, evaluating data from 136 mechanically ventilated patients with ACLF between January 2016 and August 2023. Clinical parameters were compared between patients with and without HSV bronchopneumonitis. (3) Results: 10.3% were diagnosed with HSV bronchopneumonitis (HSV group). Mortality did not differ between the HSV and non-HSV group (85.7% vs. 75.4%, p = 0.52). However, the clinical course in the HSV group was more complicated as patients required significantly longer mechanical ventilation (14 vs. 21 days, p = 0.04). Furthermore, fungal superinfections were significantly more frequent in the HSV group (28.6% vs. 6.6%, p = 0.006). (4) Conclusions: Mortality of critically ill patients with ACLF with HSV bronchopneumonitis was not increased in spite of the cirrhosis-associated immune dysfunction. Their clinical course, however, was more complicated with significantly longer mechanical ventilation.
A Streptococcus suis Strain Δcps/ssna-msly (P353L)-SC19 Provides Cross-Protection against Serotypes 2 and 9 Strain Challenges in a Mouse Model
Authors: Lu Xi , Xu Lei , Lin Lan , Zhou Liting , Dai Bingqian , Cui Shuyue , Zhang Anding
Published: March 2024

Streptococcus suis is an important zoonotic pathogen that mainly causes meningitis, septicemia, and arthritis. Due to the limited cross-protection between numerous serotypes, the existing inactive vaccines in clinical use fail to offer sufficient protection. In this study, a gene deletion-attenuated strain Δcps/ssna-msly (P353L)-SC-19 was constructed by deleting cps and ssna genes from the epidemic strain SC-19 with a mutation of SLY (P353L). The safety of Δcps/ssna-msly (P353L)-SC-19 was confirmed in both in vitro and in vivo experiments. We further demonstrated that immunization with Δcps/ssna-msly (P353L)-SC-19 induced significant cellular immunity and humoral immunity in mice and protected against infections caused by type 2 strain SC-19 (100% protection) and type 9 strain S29 (50% protection), while also preventing meningitis induced by S29. This study highlights the potential of using CPS-deficient strains to achieve cross-protection against different Streptococcus suis serotypes and develop a promising universal live vaccine.
Anti-SARS-CoV-2 IgG Seroprevalence in Tyrol, Austria, among 28,768 Blood Donors between May 2022 and March 2023
Authors: Siller Anita , Seekircher Lisa , Astl Manfred , Tschiderer Lena , Wachter Gregor A. , Penz Julia , Pfeifer Bernhard , Huber Andreas , Gaber Manfred , Schennach Harald , Willeit Peter
Published: March 2024

Background: To provide updated estimates on SARS-CoV-2 antibody seroprevalence and average antibody titres for Central Europe. Methods: In repeat cross-sectional investigations (1 May 2022 to 9 March 2023) involving 28,768 blood donors in the Federal State of Tyrol, Austria (participation rate: 87.0%), we measured Spike receptor-binding domain (RBD) and Nucleocapsid IgG antibodies (37,065 and 12,645 samples), and estimated monthly seroprevalences and geometric mean titres. Results: Median age of participants was 45.4 years (range 18–70); 43.2% were female. Spike RBD IgG antibody seroprevalence was 96.3% (95% CI: 95.6–96.9%) in May 2022, 97.4% (96.7–98.0%) in December 2022, and 97.9% (96.4–98.8%) in March 2023. Among seropositive participants, geometric mean titres increased from 1400 BAU/mL (95% CI: 1333–1471) in May 2022 to 1821 BAU/mL (1717–1932) in December 2022, and dropped to 1559 BAU/mL (1405–1729) by March 2023. Furthermore, titres differed markedly by vaccination status and history of infection, with being the highest in participants with booster vaccination and prior infection. In autumn 2022, Nucleocapsid IgG antibody seroprevalence ranged from 36.5% (35.0–38.1) in September to 39.2% (37.2–41.2) in December 2022. Conclusion: Seroprevalence of SARS-CoV-2 antibodies in blood donors from Tyrol, Austria, was remarkably stable from May 2022 to March 2023. In contrast, average Spike RBD IgG antibody titres peaked in December 2022.
Study of the River Discharge Alteration
Authors: Bărbulescu Alina , Mohammed Nayeemuddin
Published: March 2024

This article aims to analyze the alteration in water discharge due to the building of one of the largest dams in Romania. Modifications in the hydrological patterns of the studied river were emphasized by a complex technique that includes decomposition models of the series into trends, seasonal indices, and random components, as well as into Intrinsic Mode Functions (IMFs). The Mann–Kendall trend test indicates the existence of different positive slopes for the subseries S1 and S2 (before and after the inception of the Siriu dam, respectively) built from the raw series, S. The stationarity hypothesis was rejected for all series. The multifractal analysis shows two different patterns of the data series. After decomposing the subseries S1 and S2, it resulted that the seasonality indices are not the same. Moreover, the seasonal variations decreased after building the dam. Empirical Mode Decomposition (EMD) unveils different short- and long-term patterns of the series before and after building the dam, concluding that there is a significant alteration in the river discharge after the dam’s inception.
Potential of Decentral Nature-Based Solutions for Mitigation of Pluvial Floods in Urban Areas—A Simulation Study Based on 1D/2D Coupled Modeling
Authors: Neumann Jonas , Scheid Christian , Dittmer Ulrich
Published: March 2024

Urban drainage systems are generally designed to handle rainfall events only up to a certain intensity or volume. With climate change, extreme events that exceed the design storms and consequently result in flooding are occurring more frequently. Nature-based solutions (NBSs) have the potential to reduce the pressure on urban drainage systems and to increase their resilience. This study presents an approach to compare and evaluate the effectiveness of NBSs for flood mitigation using a coupled 1D/2D model of surface and sewer flow. The study analyzes the effect of infiltration systems (dimensioned to return periods of T = 5 and 100 years), various green roofs, and tree pits considering the different degrees of implementation. The NBSs are represented as LID elements according to SWMM. As expected, the mitigation effect of NBSs declines with increasing rainfall intensities. However, infiltration systems dimensioned to T = 100 years achieve almost three times the flood reduction compared to systems dimensioned to T = 5 years, even during extremely heavy rainfall events (100 mm), resulting in a reduced total flood volume of 15.1% to 25.8%. Overall, green roofs (excluding extensive green roofs) provide the most significant flood reduction (33.5%), while tree locations have the least effect.
Inclined Obstacle Recognition and Ranging Method in Farmland Based on Improved YOLOv8
Authors: Yan Xianghai , Chen Bingxin , Liu Mengnan , Zhao Yifan , Xu Liyou
Published: March 2024

Unmanned tractors under ploughing conditions suffer from body tilting, violent shaking and limited hardware resources, which can reduce the detection accuracy of unmanned tractors for field obstacles. We optimize the YOLOv8 model in three aspects: improving the accuracy of detecting tilted obstacles, computational reduction, and adding a visual ranging mechanism. By introducing Funnel ReLU, a self-constructed inclined obstacle dataset, and embedding an SE attention mechanism, these three methods improve detection accuracy. By using MobileNetv2 and Bi FPN, computational reduction, and adding camera ranging instead of LIDAR ranging, the hardware cost is reduced. After completing the model improvement, comparative tests and real-vehicle validation are carried out, and the validation results show that the average detection accuracy of the improved model reaches 98.84% of the mAP value, which is 2.34% higher than that of the original model. The computation amount of the same image is reduced from 2.35 billion floating-point computations to 1.28 billion, which is 45.53% less than the model computation amount. The monitoring frame rate during the movement of the test vehicle reaches 67 FPS, and the model meets the performance requirements of unmanned tractors under normal operating conditions.
Improvement of micro-perforated panel absorbers sound performance using resistive screens and sensitivity analysis of the composite absorber models
Authors: Laly Zacherie , Attalla Noureddine
Published: March 2024

The sound attenuation performance of a composite absorber constituted by a micro- perforated panel, a resistive screen that is inserted into the air cavity and a rigid back plate, is studied. Using a nonlinear acoustic impedance model, the surface impedance of the absorber is determined
by transfer matrix method, and the models are validated by comparison with experimental measurements performed at different sound pressure levels up to 150 dB. The contribution of the resistive screens in improving the acoustic performances of micro-perforated panel absorbers is presented.
It is shown that the resistive screen increases the resistance of the absorber resulting in broadening of the absorption frequency band and improvement of the absorption coefficient when an appropriate perforation ratio of the panel is used. Sensitivity analysis is performed at higher pressure
excitations, and the dimensionless input parameters are the perforation ratio of the panel, the ratio of the perforation diameter by the thickness of the panel, the ratio of the cavity depth by the thickness, the orifice Mach number and the resistance per unit area of the screen. The analysis
shows the impact of the input parameters on the normalized surface impedance and the sound absorption coefficient of the absorber. It is demonstrated that the resistance per unit area of the screen influences strongly the acoustic properties of the absorber in the linear regime, while the
perforation ratio of the panel and the orifice Mach number are the dominant parameters which control the acoustic behavior of the absorber in the nonlinear regime.
Inteligencia emocional y habilidades sociales en estudiantes de nivelación de una universidad
Authors: León Navarrete Marco Marcelo , Arbeláez Hurtado Ana Milena , Terán Placencia Katia Isabel , Muzo Toapaxi María José
Published: March 2024

La inteligencia emocional y las habilidades sociales son fundamentales para los estudiantes universitarios, ya que les permiten mejorar sus relaciones interpersonales, adaptarse a las demandas diarias y desarrollarse de manera efectiva. El objetivo del estudio fue relacionar la relación entre la inteligencia emocional y las habilidades sociales en los estudiantes de nivelación de una de las facultades de la Universidad Central del Ecuador, Quito, Ecuador.

Se trabajó un enfoque cuantitativo descriptivo y correlacional con un diseño no experimental y de tipo transversal, para una muestra de 128 estudiantes. Se aplicó como técnica la encuesta y el Cuestionario (TMMS-24). Los resultados destacan que el 60.16% de los estudiantes presenta un nivel adecuado de atención emocional, las dimensiones de claridad y reparación emocional se encuentran en el nivel bajo con 50.78% y 46.8% respectivamente. Las mujeres sobresalen en reparación emocional. El coeficiente de correlación Rho de Spearman, revela una correlación positiva baja.
L’origine delle proscrizioni stilane nei frammenti di Cassio Dione
Authors: Urso Gianpaolo
Published: March 2024

Les fragments de Dion Cassius sur l’origine des proscriptions ont été l’objet, dans les traductions usuelles, de quelques erreurs d’interprétation : certaines reconstructions historiques modernes, désormais abandonnées, ont influencé la lecture de ces passages, dans un sens qui ne correspond pas à la pensée de notre source. Dion Cassius a en réalité le mérite de nous restituer, dans un but polémique, certains éléments significatifs de la perspective dans laquelle Sylla lui-même interprétait son ascension au pouvoir.
Las tropas auxiliares del exercitus Hispanicus
Authors: Palao Vicente Juan Jose
Published: March 2024

Cet article est une étude sur les troupes auxiliaires dans la péninsule Ibérique au Haut-Empire. En se fondant sur les sources disponibles (littéraires, épigraphiques et archéologiques) et les travaux précédents, l’auteur analyse les problèmes posés par l’étude des auxilia hispaniques et propose de nouvelles voies de réflexion.
The proxeny -lists of Karthaia
Authors: Mack William Joseph Behm Garner
Published: March 2024

This article re-edits IG XII, 5, 542, our earliest surviving catalogue of proxenoi, arguing that it was produced by Karthaia on Keos, probably in the aftermath of the unsuccessful Kean revolt from Athens in the middle of the fourth century BC. Concentrating on the internal structure of this catalogue, the regional sections into which proxenoi were divided are identified. These provide a unique view of the horizons of this polis and its interactions with other poleis and regions which can be compared with the information provided by a shorter list from same city in the Hellenistic period (IG XII, 5, 1073 + II2, 2455).
Augustus, les astres et la mutation de l’autorité à Rome
Authors: Bakhouche Béatrice
Published: March 2024

L’attribution à Octave du titre d’Augustus signe, d’une certaine façon, le passage de la République à l’Empire. Il s’agira ici de montrer que la date du 16 janvier a été délibérément choisie par le fils adoptif de César pour des raisons astrologiques, en lien avec son signe zodiacal de prédilection, le Capricorne.
Les acrostiches de Denys à la lumière de la structure de sa Périégèse. Pour une lecture cartographique
Authors: Marcotte Didier
Published: March 2024

Les acrostiches de Denys le Périégète constituent un unicum par leur nombre et leur longueur. Leur relation entre eux et au contexte dans lequel ils apparaissent n’a jamais encore été expliquée. Cet article procède à un nouvel examen de la structure et de la méthode de la Description du monde de Denys et propose d’interpréter les acrostiches en rapport avec les itinéraires maritimes qui y sont décrits et avec la carte à laquelle Denys se réfère implicitement.
El barroco teodosiano en el poema De mortibus boum
Authors: Warburg Inés
Published: March 2024

Le poème De mortibus boum, du rhéteur Severus Sanctus Endelechius composé vers la fin IVe s. présente les signes distinctifs du baroque théodosien ou baroque tardif romain. Cette conception de l’esthétique qui a eu une grande influence dans la littérature latine de l’antiquité tardive se traduit en particulier par une rénovation totale du genre bucolique et la suprématie du surnaturel sur l’ordre naturel troublé, selon l’idéologie triomphaliste de la poesie theodosienne.
Jean-Pierre Vernant et le mythe hésiodique des races. Essai d’analyse sociologique
Authors: Pébarthe Christophe
Published: March 2024

Dans sa dernière livraison (n° 218, 2016), la revue L’Homme consacre notamment deux articles aux analyses fameuses que Jean-Pierre Vernant a naguère consacrées au mythe hésiodique des races. Le premier, «Jean-Pierre Vernant et l’analyse structurale. Le mythe hésiodique des races » , rédigé par Aurélien Gros, qui a récemment soutenu une thèse le 7 mars 2015 sous la direction de François Hartog et intitulée L’anthropologie historique de Jean‑Pierre Vernant. Enquête épistémologique,

tente d’expliquer comment l’helléniste articulait de manière originale la psychologie historique d’Ignace Meyerson et l’anthropologie structurale de Claude Lévi-Strauss. Cette articulation serait à l’origine de l’anthropologie historique. Le second, «Le mythe hésiodique des races, oeuvre de langage. Jean‑Pierre Vernant et après » , écrit par Pierre Judet de La Combe, souligne l’intérêt qu’il y a à intégrer une dimension pragmatique à cette analyse structurale du mythe, c’est-à-dire à considérer l’intervention singulière d’Hésiode sur le matériau mythique. Or, lorsque sont rappelés le contexte intellectuel et académique des années 1950 et 1960 et les principes de l’analyse structurale lévi-straussienne des mythes, le rapport de Jean-Pierre Vernant au structuralisme apparaît comme critique. Derrière son «Essai d’analyse structurale » , l’helléniste proposait en réalité une démarche différente de celle de Claude Lévi-Strauss. À l’aune de ce qui apparaît surtout comme une analyse sociologique, le mythe des races, tout autant rapporté que composé par Hésiode, témoigne d’un temps présent conçu comme indéterminé duquel le poète tente de faire surgir un ordre, celui de la justice (dikê), dans un récit mythique rendant compte de la genèse et de la structure de son monde social.
Greek cults and their sacred laws on dress-codes: The laws of Greek sanctuaries for clothing, colour, and penalties against misbehaviour
Authors: Karatas Aynur-Michèle-Sara
Published: March 2024

Les inscriptions grecques sur les codes vestimentaires cultuels réglementaient le coût maximum, le tissu, la couleur des vêtements, les coiffures et les bijoux autorisés dans les sanctuaires, lors des rituels et des festivals. La réglementation sur les vêtements cultuels visait à renforcer l’expérience religieuse partagée plutôt qu’à afficher la richesse et la vanité qui peuvent se manifester par des vêtements, des bijoux et des coiffures. Certains règlements interdisaient les vêtements de couleur, les chaussures, les bijoux en or et les coiffures sophistiquées. Les vêtements blancs semblent avoir été privilégiés pour les rituels et les festivals cultuels. Contrairement aux adorateurs, les prêtres, en tant qu’agents rituels, étaient autorisés à porter des vêtements violets et des bijoux en or lors des festivals et des cérémonies. Le présent document rassemble toute une série de sources épigraphiques sur les réglementations en matière de vêtements cultuels.
Afficher le spectacle en Gaule Belgique : l’Énéide de Virgile au théâtre de Vendeuil-Caply (vicus des Bellovaques)
Authors: Hoët-van Cauwenberghe Christine
Published: March 2024

Les fouilles de Gérard Dufour ont révélé en 1979 un titulus pictus sur le mur extérieur du premier état de construction du grand théâtre de Vendeuil-Caply (cité des Bellovaques). Nous proposons une nouvelle lecture de cet écrit incomplet peint en rouge comme élément d’une affiche de spectacle. Nous l’identifions à un vers de l’Énéide de Virgile, qui a été utilisé deux fois dans ce poème épique (I, 313 et XII, 165). Le titulus pictus trouvé dans une villa d’Otford (Kent) pour la même période, nous donne un parallèle. Ce vers et peut-être d’autres ainsi que des images, peints sur ce mur, étaient susceptibles d’attirer le public et de faire naître un suspens pour le spectacle du type pantomime donné à l’intérieur du théâtre.
Entre Nîmes et Rome : sur les traces d’une famille nîmoise, les Sammii
Authors: Christol Michel
Published: March 2024

The revision of an incomplete inscription from Nîmes makes it possible to study the Sammii family, which is attested most of all at the end of the first and beginning of the second centuries. The family reached the highest levels of the provincial nobility, but its importance can also be appreciated through a series of Roman inscriptions, which allows us to measure the networks of relationships it had established within the upper levels of society in the city of Nîmes, in particular with the senatorial family of the Aemilii.
MAKĀSID-I ŞERÎA BAĞLAMINDA KUR’ÂN AHKÂMININ DEĞİŞMESİ -MUHAMMED TÂHİR B. ÂŞÛR ÖRNEĞİ-
Authors: Şola Hanefi
Published: March 2024

Son iki yüzyılda Müslümanların Batı karşısında yaşadıkları mağlubiyetler sonucu İslam dünyasında dine karşı faklı yaklaşımlar ortaya çıkmıştır. Bu kapsamda bir kesim İslam dünyasının mağlubiyetinin temel sebebi olarak dini görmüştür. Bir diğer kesim bunun nedenin dinden uzaklaşmak olduğunu söylemiştir. Bir grup ise bunun sebebini din ile geleneğin iç içe girmesiyle açıklamıştır. Mağlubiyetin gerekçesinin din ile geleneğin iç içe geçmesi olarak görenlerin bazıları dinin gelenekten tamamen arındırılması gerektiğini savunurken bazıları gelenekteki bazı imkanlardan faydalanılması gerektiğini düşünmüştür. Bu bağlamda gelenekteki var olan ve kendisinden faydalanılması gereken imkanların içinde en fazla öne çıkan düşüncenin makâsıd-maslahat olduğu görülmektedir. Geleneğin önemli bir konusu olan makâsıd-maslahat düşüncesinden faydalanılması gerektiğini düşünenler, bu düşünceden hareketle hakkında ayet bulunan bazı hükümlerin çağdaş dönemin ihtiyaçları doğrultusunda değişebileceği şeklinde yorumlamışlardır. Bu çalışmada da makâsıd-maslahat düşüncesini gündemine alan Muhammed Tâhir b. Âşûr’un (1879-1973) özellikle Kur’ân hükümlerinin değişip değişemeyeceği konusundaki yaklaşımının ortaya konması amaçlanmıştır. Çalışmada öncelikle İbn Âşûr’ûn makâsıd-maslahat düşüncesi ele alınmıştır. Ardından da çağdaş dönemde, farklı yorumlanması gerektiği düşünülen bazı Kur’an hükümlerine temas edilmiş ve İbn Âşur’un bu hükümler hakkındaki yaklaşımı ortaya konmaya çalışılmıştır.
TAHAKKÜMÜN MUHAKEMESİ: İHVÂN-I SAFÂ’DA HAYVANLARIN ÖZGÜRLEŞME MÜCADELESİ
Authors: Özkan Abdullah
Published: March 2024

İslam düşüncesinde hayvan etiğiyle alakalı karşımıza çıkan en dikkat çekici metinlerden biri, İhvân-ı Safâ Risâleleri’nin “Hayvanların Yaratılışının Keyfiyeti ve Onların Sınıfları Üzerine” başlıklı yirmi ikinci risâlesidir. Risâlede hayvanlar tasnif edilmekte ve onların sınıfları ve türleri hakkında betimlemeler yapılarak ayrıntılı bilgiler verilmektedir. Bu yönüyle risâle zoolojiye dairdir. Fakat bu risâle, içinde bulundurduğu ilginç hikâye nedeniyle teorik felsefenin bir alt dalı olan zoolojiye dair bir eser olmanın ötesine geçer. Bu yönüyle risâle bütün varlıkların ahlaki bir ideal perspektifinden incelendiği ve pratik felsefenin geleneksel kısımları olan siyaset, ekonomi ve kişisel ahlakın konuları içinde incelenebilecek konuların ele alındığı bir esere dönüşür. Hikâyede hayvanlar insanların kendilerine yaptıkları zulüm nedeniyle onları cinlerin kralına şikâyet edip Peter Singer’in Hayvan Özgürleşmesi kitabının mesajını andırırcasına özgürlüklerini talep ederler. Dolayısıyla risâle hayvan hakları ile alakalı günümüzde yürütülen tartışmaların Orta Çağda yapılmış iyi bir örneğidir. Risâle, insanın türe özgü özellikleri nedeniyle üstün olduğu iddiasına hayvanların ağzından meydan okumakta, insanlar ve hayvanlar arasındaki muhtemel eşitliğe dikkat çekmektedir. Bu çalışmada insanların sahip oldukları üstünlüğe dair delilleri ve hayvanların onlara itirazları risâlenin teorik taraflarına çok fazla girilmeden sunulacaktır.
Iemanjás espetacularizadas e imagens do patrimônio especulares: as religiões de matrizes africanas no litoral Catarinense reiteradamente invisibilizadas
Authors: Benício Danielle Rocha , Otero Júlia Charão , Geremias Rafael Costa
Published: March 2024

Visa-se, diante do espelho de Iemanjá, refletir acerca da invisibilização/desaparição do patrimônio religioso afrodescendente implantado em espaços naturais do litoral catarinense, em lócus da divindade à beira-mar, a partir de esculturas da orixá Mãe do Mar pertencentes às religiões de matrizes africanas, matérias de reiterados ataques de vandalismos e danos, por exemplo, nas costas de Florianópolis, Laguna e Itajaí. Daí decorrem os objetivos específicos de: adentrar a encruzilhada entre o campo da História do Tempo Presente e da revisão decolonial e os movediços da preservação do legado afrodiaspórico, ratificando a abertura de caminhos para a proteção de bens representativos de sujeitos históricos negros subalternizados; mergulhar nas ideias e nos ideais envoltos na imaginária e na estatuária da Mãe Sereia; fitar as amarrações entre a imagem da divindade feminina e os seus contextos natural, ligado às águas, e cultural, articulado à pesca; mirar o espelhamento entre a instância dos monumentos e os entes detentores da herança monumental; e, então, desvelar as tentativas de desaparição dos bens potentes de empoderamento identitário vinculados à religiosidade afrodescendente. Para isso, incorpora-se a pesquisa qualitativa, assentada na decolonialidade e estruturada na cosmovisão afro-centrada e afro-referenciada, transfigurando o saber/fazer hegemônico remanescente no tempo em espiral, não linear, onde o início entrelaça-se com o fim. Desse modo, recorre-se à revisão bibliográfica, à investigação iconográfica, à vivência e ao registro fotográfico no território sagrado (natureza). Fecha-se essa gira refletida, abrindo-se visadas de (re)existência, (re)encantamento e salvaguarda das realizações patrimoniais diversas da ancestralidade preta em Santa Catarina. Tal propósito justifica-se frente à violência crescente dos atos de aniquilamento e exterminação das obras monumentais testemunhos presentes da negritude e suas manifestações sagradas, explicitando a realidade extremada de preconceito, racismo e intolerância religiosa em Santa Catarina. Em concomitância, contribui para a revisão sobre a seleção e a oficialização do acervo monumental a ser protegido legalmente pelo Estado, como também mantido e restaurado com recursos governamentais.
Professional development of english foreign language teachers in Indonesia: non-english educational background
Authors: Dewi Melawati , Kurniawan Eri
Published: March 2024

The paper reports on the results of a study aiming to analyze the teachers’ perception of their professionalism in teaching English as non-English education graduates as well as the challenges that are faced by the teachers. The data were collected from observation and interview with two English teachers of the Senior High School in Subang, West Java, Indonesia. The data were analyzed by a qualitative method through three steps: reduction, display and conclusion. From the interview result, two teachers have similar perceptions of professionalism in teaching. They believed that professional development can be improved by joining some events and programs in an effort of developing their pedagogical competence such as seminars, workshops, short courses or teacher training related to teaching in order to develop their knowledge of teaching methods. Meanwhile, the observation results show that both teachers have not applied all practical professional development activities in their classrooms, such as the implementation of lesson study is not achieved well and the teachers are not familiar with self-reflection.  The result highlighted from two teachers’ perceptions of being professional that they are consciously confident that professionalism is undeniable for the sake of students’ achievement in learning English by having various of professional development courses or trainings. In conclusion, the researcher assumed that their teaching English professionalism could be developed as long as they have taught English skills which can be reinforced by some experiences in teaching English, applying pedagogical knowledge and attending teacher’s programs that can improve their competence in teaching.
Mahatma Gandhi - Liquor addiction is a curse to the nation's economic growth
Authors: Annapurna Indukuri
Published: March 2024

Mahatma Gandhi identified the difficulties faced by wives of alcohol/liquor addicts in maintenance of family necessities and upbringing their children. And indecent behaviour of drunkards with their spouses and women in their families. Children are deprived from their education,  provision of nutritious food,  healthy environment, their psychology and character of children are also disturbed that is the alcohol addictions is destroying National future itself, because the children are the future of Nation. But, because of misbehaviour of drunkard family member and continuous quarrels within the family forced the children to become child labour. This problem is persistent even in 21st century. If the humanity doesn't realize this evil of liquor drinking habit the future of the mankind ends up in melancholy. The money earning by State Governments from taxation on or liquor sales is heinous and crime destroying peace and prosperity of many families.  The deprivation to the State Governments of the alcohol revenue is of the least importance in the prohibition campaign. The country is simply impatient of the evil itself. In no country in the World will it be possible to carry on this illegal business in the face of the united and the enlightened opposition of a people, such as is now to be witnessed in the economy of India.
Advancing Organoid Engineering for Tissue Regeneration and Biofunctional Reconstruction
Authors: Jin Hairong , Xue Zengqi , Liu Jinnv , Ma Binbin , Yang Jianfeng , Lei Lanjie
Published: March 2024

Tissue damage and functional abnormalities in organs have become a considerable clinical challenge. Organoids are often applied as disease models and in drug discovery and screening. Indeed, several studies have shown that organoids are an important strategy for achieving tissue repair and biofunction reconstruction. In contrast to established stem cell therapies, organoids have high clinical relevance. However, conventional approaches have limited the application of organoids in clinical regenerative medicine. Engineered organoids might have the capacity to overcome these challenges. Bioengineering—a multidisciplinary field that applies engineering principles to biomedicine—has bridged the gap between engineering and medicine to promote human health. More specifically, bioengineering principles have been applied to organoids to accelerate their clinical translation. In this review, beginning with the basic concepts of organoids, we describe strategies for cultivating engineered organoids and discuss the multiple engineering modes to create conditions for breakthroughs in organoid research. Subsequently, studies on the application of engineered organoids in biofunction reconstruction and tissue repair are presented. Finally, we highlight the limitations and challenges hindering the utilization of engineered organoids in clinical applications. Future research will focus on cultivating engineered organoids using advanced bioengineering tools for personalized tissue repair and biofunction reconstruction.
Factors Modulating the Variability of Eddy Kinetic Energy in the Southern Ocean from Idealized Simulations
Authors: Cai Yongqing , Chen Dake , Chen Ru , Lei Ruibo , Wu Lichuan
Published: March 2024

The Southern Ocean is characterized by high levels of eddy activity, which are crucial for the vertical exchange or transfer of matter, energy, and momentum. Previous studies have shown that the variability of eddy kinetic energy (EKE) in the Southern Ocean is primarily intrinsic. However, the factors that modulate the forced and intrinsic variability of the EKE remain unclear. In this study, we conduct a series of idealized simulations and apply ensemble analysis to investigate the impact of topography and wind-stress perturbations on the forced and intrinsic variability of the EKE and their relative contributions. The results show that while the large wind-stress perturbation obviously increases the forced variability of EKE by enhancing the Ekman response, the topography not only amplifies the forced variability by sharpening isopycnals and energizing the mean flow but also intensifies the intrinsic variability of EKE. However, EKE variabilities in both complex-topographic and flat-bottom cases are dominated by their intrinsic components, even when driven by escalated wind-stress perturbations. These findings deepen our understanding of the eddy field, its ongoing variability in the Southern Ocean, and its potential impact on the balance of heat, carbon, and freshwater.
B Cells and IL-21-Producing Follicular Helper T Cells Cooperate to Determine the Dynamic Alterations of Premetastatic Tumor Draining Lymph Nodes of Breast Cancer
Authors: Mao Xinrui , Tang Xinyu , Pan Hong , Yu Muxin , Ji Sihan , Qiu Wen , Che Nan , Zhang Kai , Huang Zhendong , Jiang Yunshan , Wang Ji , Zhong Zhaoyun , Wang Jiaming , Liu Mingduo , Chen Mingkang , Zhou Wenbin , Wang Shui
Published: March 2024

Metastasis is the major cause of cancer-related death, and lymph node is the most common site of metastasis in breast cancer. However, the alterations that happen in tumor-draining lymph nodes (TDLNs) to form a premetastatic microenvironment are largely unknown. Here, we first report the dynamic changes in size and immune status of TDLNs before metastasis in breast cancer. With the progression of tumor, the TDLN is first enlarged and immune-activated at early stage that contains specific antitumor immunity against metastasis. The TDLN is then contracted and immunosuppressed at late stage before finally getting metastasized. Mechanistically, B and follicular helper T (Tfh) cells parallelly expand and contract to determine the size of TDLN. The activation status and specific antitumor immunity of CD8
+
T cells in the TDLN are determined by interleukin-21 (IL-21) produced by Tfh cells, thus showing parallel changes. The turn from activated enlargement to suppressed contraction is due to the spontaneous contraction of germinal centers mediated by follicular regulatory T cells. On the basis of the B-Tfh-IL-21-CD8
+
T cell axis, we prove that targeting the axis could activate TDLNs to resist metastasis. Together, our findings identify the dynamic alterations and regulatory mechanisms of premetastatic TDLNs of breast cancer and provide new strategies to inhibit lymph node metastasis.
Properties of Lunar Dust and Their Migration on the Moon
Authors: Jin Hong , Li Xiongyao , Wei Guangfei , Zhang Xiaoping , Xie Lianghai , Gan Hong , Zhang Aibing , Zhang Xianguo , Li Lifang , He Zhaoguo , Zhao Yuyan
Published: March 2024

Lunar dust, the finest fraction of lunar regolith, has undergone important space weathering on the Moon. It not only serves as a record of the evolution of the lunar surface environment and the modification of mineral properties, but also influences the lunar surface environment through dust transport. Our current understanding of the properties and transport mechanisms of lunar dust on the lunar surface, however, remains limited. With rapid development of lunar exploration, it is necessary to further study the problem and meet the need of future lunar exploration missions. The lunar surface is the primary environmental space where uncrewed lunar rover activity, crewed lunar exploration, and lunar base construction take place. The lunar dust will distribute in such a space area due to electrostatic lifting and impacted sputtering, which will pose a threat to lunar surface exploration activities. In addition, lunar dust transport is closely related to lunar horizon glow, lunar swirl, and lunar magnetic anomaly. Understanding the properties and transport mechanisms of lunar dust is key to comprehending the formation of these scientific phenomena. Therefore, a systematic and in-depth investigation of lunar dust properties and dust transport patterns is urgently required to advance lunar science and implement lunar exploration projects. In this study, we summarize the physical and chemical properties of lunar dust and our understanding of dust transport on the lunar surface, identify remaining challenges and issues in the study of lunar dust, and offer perspectives on this research field.
FORCED OSCILLATION TECHNIQUE (FOT) – A NOVEL METHOD FOR THE DETECTION OF EARLY AIRWAY CHANGES
Authors: Stoimenova Plamena , Mandadzhieva Stoilka , Marinov Blagoi
Published: March 2024

According to the World Health Organization in 2019 chronic obstructive pulmonary disease (COPD) was the third leading cause of death worldwide, causing more than 3 million deaths whereas bronchial asthma affected more than 250 million people and caused 455 000 deaths. Both diseases are chronic obstructive conditions which need to be diagnosed early in order to prevent or slow down the complications. Consequently the world requires new effortless methods for diagnosis of airway obstructions, especially for small children and people who cannot perform the spirometry maneuver. The purpose of this report is to describe the objectives of the forced oscillation technique (FOT) and to establish its applications in the clinical practice. Studies and clinical cases regarding pulmonary function testing are summarized and analyzed. They are found in the following databases - PubMed, Google Scholar and Science Direct. Spirometry is the ‘gold standard’ for the diagnosis of airflow obstruction but it requires effort and can be difficult for patients to perform. Forced oscillation technique (FOT) on the other hand is a relatively new method that may hold the key to identifying smoking-related respiratory early alterations and childhood asthma. FOT requires tidal breathing while applying external, small amplitude oscillations in order to determine the response of the respiratory system. Therefore, it is easy for pre-school children to perform. The benefit of FOT should be taken into account for patients who cannot perform spirometry or other pulmonary function ttests. The minimal cooperation of the patient and the easy tidal breathing maneuvers make this method a great option for every pulmonologist. Compared to spirometry this technique may be more sensitive in the detection of disturbances of the peripheral airways and may be effective for the control of therapy at a long term. The Forced oscillation technique has been successfully applied in many pediatric respiratory disorders, such as asthma, cystic fibrosis, and chronic lung disease. Considering these qualities FOT may be used as an alternative of spirometry in heterogenous ventilatory disturbances of the small airways.
Usulan Strategi Penetapan Value Based Pricing pada UMKM
Authors: Dinanti Maharani Putri
Published: March 2024

way possible. Interviews with purposive sample determination and observation were conducted using the descriptive qualitative approach. The data was analyzed using a variety of approaches, including the Sustainable Competitive Advantage (SCA) framework, the VRIO framework, and TOWS analysis Then the researcher conducted a content analysis to propose a pricing strategy. The recommended proposal is a pricing strategy with a Value-Based Pricing approach.

Keywords: Pricing Strategy, Value-Based Pricing
Las tecnologías de información y comunicación en la modalidad a distancia en educación universitaria
Authors: Velásquez-Humpire Wily , Guerra-de González Yetzy Beatriz
Published: March 2024

Este artículo documental tuvo como propósito realizar una aproximación teórica en base a las experiencias del profesorado y del estudiantado con el uso de las Tecnologías de Información y Comunicación (TIC) en la Educación Superior a Distancia (EAD). La metodología de investigación fue de revisión bibliográfica, exploratoria y explicativa, sustentada en información proveniente de revistas indexadas de Redalyc y Scielo sobre estudios realizados entre los años 2017- 2023. Como resultado, se resalta cómo las TIC contribuyen en el desarrollo del proceso educativo a distancia dentro de la Educación Superior (ES). Por tanto, se concluyó que la incidencia de estas herramientas en la formación profesional ha sido significativa en la educación superior y en el trabajo remoto, pues ha contribuido con el desarrollo de competencias profesionales importantes para el desenvolvimiento en contextos educativos complejos.
Adsorption and desorption characteristics of rare earth ions on halloysite surfaces
Authors: Long Qibang , Yan Huashan , Zhou Xiaowen , Qiu Seng , Qiu Tingsheng
Published: March 2024

Rare earths (REs) are primarily adsorbed in ionic form on the surface of clay minerals such as halloysite in ionic rare earth ores. As a result, understanding the adsorption and desorption behaviors of RE ions on the surface of the halloysite may contribute to clarifying the mineralization process of ionic rare earth ores and provide a theoretical framework for the optimization of the extraction process. The adsorption and desorption characteristics of light (Nd3+), medium (Eu3+), and heavy (Lu3+) RE ions on the surface of halloysite-10 Å were comprehensively examined in this study. Because REs are more inclined to form an outer layer and inner layer adsorption when halloysite is protonated and deprotonated with the range of pH, respectively, pH has a significant impact on how halloysite adsorbs and desorbs. The experiment findings indicate that RE concentration, duration, and pH all increased the adsorption capacity of light, medium, and heavy REEs, and exhibited some selectivity for heavy REEs. Nd3+, Eu3+ and Lu3+ ions adsorption processes on the surface of Halloysite-10 Å are consistent with the Langmuir isothermal adsorption model and pseudo-second-order kinetic equations. The desorption efficiency of Lu3+ decreases dramatically with increasing pH due to hydrolysis and more inner layer adsorption than that of Nd3+ and Eu3+.
2. On How to Distinguish Critique from an Infringement of Academic Freedom
Authors: Kronfeldner Maria
Published: March 2024

Abstract To have a well-functioning principle of academic freedom, we need to distinguish critique from an infringement of academic freedom. To achieve this goal, this paper presents three necessary conditions for something to be an infringement of academic freedom. These
conditions allow to delineate cases in which at least one of the three conditions is not fulfilled. These are contrast cases that might – at first glance – look like infringements of academic freedom but are, in fact, not so. I will refer to five such kinds of contrast cases: (1)
discrimination and thus a more general kind of unjust treatment of a person engaged in academic affairs, (2) infringement of freedom of speech or other non-academic intellectual freedoms, (3) mere critique, (4) justified critique that leads to justified limitations of someone’s academic
freedom and (5) cases of deep disagreement. Special attention will be given to vulnerabilities concerning unjustified silencing of critique, which haunt fields that lack clear and agreed-on ethical or academic standards.
Potential of targeting signal-transducing adaptor protein-2 in cancer therapeutic applications
Authors: Maemoto Taiga , Sasaki Yuto , Okuyama Fumiya , Kitai Yuichi , Oritani Kenji , Matsuda Tadashi
Published: March 2024

Adaptor proteins play essential roles in various intracellular signaling pathways. Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein that possesses pleckstrin homology (PH) and Src homology 2 (SH2) domains, as well as a YXXQ signal transducer and activator of transcription 3 (STAT3)-binding motif in its C-terminal region. STAP-2 is also a substrate of breast tumor kinase (BRK). STAP-2/BRK expression is deregulated in breast cancers and enhances STAT3-dependent cell proliferation. In prostate cancer cells, STAP-2 interacts with and stabilizes epidermal growth factor receptor (EGFR) after stimulation, resulting in the upregulation of EGFR signaling, which contributes to cancer-cell proliferation and tumor progression. Therefore, inhibition of the interaction between STAP-2 and BRK/EGFR may be a possible therapeutic strategy for these cancers. For this purpose, peptides that interfere with STAP-2/BRK/EGFR binding may have great potential. Indeed, the identified peptide inhibitor successfully suppressed the STAP-2/EGFR protein interaction, EGFR stabilization, and cancer-cell growth. Furthermore, the peptide inhibitor suppressed tumor formation in human prostate- and lung-cancer cell lines in a murine xenograft model. This review focuses on the inhibitory peptide as a promising candidate for the treatment of prostate and lung cancers.
THE EFFECT OF Γ-IRRADIATION ON PHOTOLUMINESCENT PROPERTIES OF CDZNSE /ZNSE QUANTUM PITS
Authors:   Karakalpak state univessity named after Berdakh, Uzbekistan, M.B. Sharibaev , Q. Turganbayeva ,   Karakalpak Institute of Agriculture and agricultural technologies, Nukus, Uzbekistan, G. Saparniyazova ,   Karakalpak Institute of Agriculture and agricultural technologies, Nukus, Uzbekistan
Published: March 2024

In this paper, the effect of irradiation with γ-quanta Co60 on the optical characteristics of single and several compressed-stressed CdZnSe /ZnSe is a composition with a composition x = 0.2-0.4 grown by molecular-beam epitaxy. The breakdown of quantum pits after irradiation by γ-quanta was studied.
Sobrecarga en la presencia de ansiedad, depresión y estrés de los cuidadores de discapacitados
Authors: Castelo-Rivas Walter Patricio , Agreda Sigindioy Fany Edilma , Naranjo-Armijo Franklin Gerardo , Vinces Jadán Alisson Melissa , Alcívar Rivadeneira Mauricio Guillermo , Lamar Guale Nayeli Lilibeth
Published: March 2024

Objetivo. Identifcar la relación entre la  sobrecarga y la presencia de estrés, ansiedad y depresión en los cuidadores de personas con  discapacidad. Métodos. El estudio fue cuantitativo, de alcance correlacional y diseño transversal. Un total de 384 cuidadores de personas con discapacidad formaron parte de la  muestra de estudio, seleccionada a partir de un muestreo por conveniencia. Se aplicó una encuesta con 47 preguntas. Los análisis  estadísticos fueron desarrollados en Statistical Package for Social Sciences 24, calculando tanto la normalidad de los datos como las correlacionales de las variables. Resultados. Existía relación entre la sobrecarga del  cuidador y la presencia de estrés, ansiedad y depresión en los cuidadores de personas con discapacidad. puesto que el exceso de actividades generadas a raíz del  cuidado de personas con discapacidad se relacionó fuertemente con la presencia de estrés y de manera moderada con la ansiedad y la depresión. Conclusión. Se identifcó que la sobrecarga del cuidador influye en la presencia de ansiedad, depresión y estrés.