bluuebunny/crossref_metadata_2025 huggingface dataset:
Uso de tecnologías digitales por estudiantes universitarios para fines educativos en la era postpandemia
Authors: Chaparro Medina Paola Margarita , Cervantes Hernández Rubén , Cordero Hidalgo Aixchel
Published: September 2023

La pandemia de COVID-19 impulsó la adopción de herramientas digitales en los sistemas educativos para facilitar los procesos formativos. Este estudio tuvo como propósito examinar el uso de plataformas, aplicaciones y redes sociodigitales con fines educativos por parte de estudiantes universitarios en Zacatecas, México. Para lograr dicho objetivo se empleó un enfoque cuantitativo con un diseño transversal descriptivo, obteniendo datos a través de un cuestionario analizado con SPSS, con una muestra de 266 individuos, con un nivel de confianza de 95% y un margen de error de 6%. Entre los resultados se obtuvo que los estudiantes universitarios en Zacatecas hacen uso de herramientas digitales con fines educativos. Se observa que la aplicación considerada de mayor utilidad es Google, mientras que Google Classroom es la más empleada. Asimismo se destaca que WhatsApp y Google Classroom son percibidas como las más eficaces. Por último, las personas participantes consideran óptimas, eficientes y seguras a las redes sociodigitales para el proceso de aprendizaje, lo que contribuye significativamente al desarrollo académico del estudiantado. Las redes sociodigitales desempeñan un papel fundamental en la formación de los individuos en el siglo XXI, por lo que su utilización con fines educativos resulta indispensable.
Categorisation of Fields of Study in Light of Data
on Three Years of Graduates
Authors: Rocki Marek
Published: September 2023

W artykule przedstawiono wyniki kategoryzacji kierunków studiów wykorzystującej
dane o trzech rocznikach absolwentów, dostępne w ogólnopolskim systemie
monitorowania ekonomicznych losów absolwentów. Kategoryzacja ta stosuje dwa
wybrane syntetyczne wskaźniki wyznaczane dla pierwszego i piątego roku od uzyskania
dyplomu. Kombinacje wartości tych wskaźników pozwalają na wyodrębnienie
kategorii kierunków, których absolwenci są w różny sposób oceniani przez
pracodawców. Wyniki kategoryzacji wskazują na związek ekonomicznych losów
absolwentów z dziedziną nauki, do której przypisano kierunek, z poziomem rozwoju
województw, a także na zróżnicowanie kategorii ze względu na formę i poziom studiów.
Szczególną uwagę poświęcono kierunkom przypisanym do nauk społecznych.
Wskazano uczelnie, których absolwenci trwale uzyskują wyodrębnione kategorie.
Community Archaeology at Tell Balata, Palestine
Authors: Taha Hamdan , van der Kooij Gerrit
Published: September 2023

This chapter introduces the community archaeology experience at Tell Balata, Palestine. It contextualises the aims, objectives and activities of a four-year joint project of the Palestinian Department of Antiquities and Cultural Heritage, the Faculty of Archaeology of the University of Leiden, and UNESCO’s Ramallah office, in cooperation with the local community. The site is identified with ancient Shechem and had been excavated in the last century by a series of archaeological expeditions, using a typical colonial archaeology, in which the involvement of the local community has been limited to physical work and dirt removal. The project’s main concern was the rehabilitation of the neglected archaeological site, and its development into a modern archaeological park for the benefit of the local community. The Tell Balata Archaeological Park was guided by a management plan based on UNESCO and ICOMOS principles and the management guidelines for World Cultural Heritage sites, in line with provisions of international charters and conventions. The plan determined the level and nature of community involvement. Community outreach activities included clearance work, excavations at certain spots to build capacity in the heritage sector in marginalised areas, involving workers in excavation and restoration work, and connecting the people with the place. Other outreach activities included promotion work, such as signposting outside the site, a site map and trail signage on site, leaflets, education and awareness programmes, the oral history survey, site staff training, and the interpretation centre. Complementary activities included excavation reports, a teacher’s handbook, a guidebook, a documentary film, and additional visitor-friendly provisions on site to facilitate and promote domestic and international tourism.
Tata Kelola Koperasi Syari’ah untuk Keberlanjutan Usaha
Authors: Suryana  , Muhammad Ali  , Syafrizal Ikram  , Dudi Abdul Halim  , Tria Apriliana  , Ingrid Larasati Agustina
Published: September 2023

Pengabdian kepada Masyarakat ini bertujuan untuk memberi pelatihan mengenai tata kelola koperasi syari’ah dan menyusun pembentukan pengurus dan pengawas pada koperasi sekunder. Peserta merasa mendapat pengetahuan langsung ke pokok permasalahan sehingga merasa terbantu dalam memahami sistem tata kelola koperasi syari’ah untuk keberlanjutan usaha mereka. Pengetahuan, pemahaman dan keterampilan peserta tentang pentingnya tata kelola, keberlanjutan usaha koperasi syari’ah mengalami peningkatan yang signifikan, hal ini dapat dilihat dari luaran yang dicapai, yaitu  kemampuan peserta merumuskan kembali tata kelola dan berhasil membentuk kepengurusan yang baru pada koperasi sekunder syari’ah.
Pemberdayaan Pengusaha UMKM Binaan KADIN Kota Bandung Berkarakter Technopreneurship Yang Berdaya Saing Global Melalui Implementasi Digital Marketing
Authors: Brahmana Sunardi Sembiring , Pratminingsih Sri Astuti , Sugandi Gagan , Suganda Uce Karna
Published: September 2023

Perkembangan teknologi informasi saat ini berjalan dengan cepat dan merubah perilaku konsumen. Setiap perusahaan berusaha untuk beradaptasi terhadap perubahan ini, salah satunya dengan mengadopsi digital marketing. UMKM yang merupakan mayoritas pengusaha di Indonesia juga harus mengikuti perkembangan ini. Tujuan penelitian ini untuk mengetahui adopsi atau implementasi digital marketing diantara para pelaku UMKM binaan KADIN kota Bandung. Penelitian ini menggunakan teknik observasi, wawancara, dokumentasi dan teknik pengambilan sampel adalah purposive sampling dengan objek penelitian adalah pemilik UMKM yang menjadi binaan KADIN Bandung. Hasil dari penelitian ini menunjukkan bahwa adanya ketertarikan pelaku UMKM untuk menggunakan digital marketing dalam memasarkan produk UMKM. Kemampuan, kesadaran akan manfaat digital marketing dan juga implementasi digital di UMKM sudah cukup baik, terutama bagi generasi yang lebih muda. Peran pemerintah, perguruan tinggi dan organisasi lainnya dibutuhkan oleh para pelaku UMKM untuk meningkatkan kemampuan mereka dalam mengimplementasikan digital marketing
Penerapan Sistem Informasi Akuntansi Dalam Kualitas Laporan Keuangan SMPN 12 Bandung
Authors: Heriansyah Dasep , Pardian Andra
Published: September 2023

Penelitian ini bertujuan untuk mengetahui besarnya pengaruh sistem informasi akuntansi terhadap kualitas laporan keungan di SMPN 12 Bandung. Dengan variabel independen yaitu sistem informasi akuntansi dan variabel dependen yaitu kualitas laporan keuangan. Sumber data yang didapatkan berupa data primer, yakni menggunakan kuisioner dengan jumlah responden 50 orang. Teknik analisis yang digunakan dalam penelitian ini adalah regresi linier sederhana. Selain itu, uji hipotesis yang dipakai adalah uji statistik t. Dengan persyaratan uji validitas, uji reliabilitas dan uji prasyarat analisis. Hasil uji t yang didapatkan yaitu sebesar 4,120 lebih besar dari nilai t tabel 2,011. Dan dari hasil koefisien determinasi menjelaskan bahwa nilai hubungan variabel sistem informasi akuntansi terhadap kualitas laporan keuangan 63,7% sedangakan 36,3% dipengaruhi oleh variabel lain yang penulis tidak cantumkan dalam penelitian ini.
High School Students' Mathematical Communication Skills Through Ethnomatematics-Based Realistic Mathematics Learning Approaches in Geometry Transformation Materials
Authors: Khusnul Hotimah  , Lujeng Lestari Isnawati
Published: September 2023

Mathematical communication ability is the ability of students to use mathematics as a form of communication (the language of mathematics) and student's ability to convey the mathematics they learn as the content of the message to be conveyed. This study aims to describe the Mathematical Communication Skills of High School Students Through an Ethnomatematics-Based Realistic Mathematics Learning Approach on Geometry Transformation Materials. This research is a type of descriptive research with a qualitative approach. The selection of subjects used in this study used an interpersonal intelligence questionnaire, which involved all students of class XI IIS 3 State Islamic High School 1 Pasuruan. Based on the interpersonal intelligence questionnaire scores, three subjects were selected with high, medium, and low levels of interpersonal intelligence. Then, these three subjects will examine the student's ability to draw the correct solution, explain the answer systematically, and construct a problem into a mathematical model. The results of this study indicate that the mathematical communication skills of students with high, medium, and low levels of interpersonal intelligence have many differences in problem-solving on the questions given
PEMANFAATAN LAHAN PEKARANGAN RUMAH SEBAGAI APOTIK HIDUP
Authors: Fachriansyah Aditya , Pratama Ade Waluyo , Prasandi Malpin , Pranata Egi Patli , Rahayu Ega , Pradita Ratna Nabila , Silalahi Iren Rosalina , Wahyuni Sri , Kencana Anindia Tri Rahma , Herliza Mipi , Zahara Nela
Published: September 2023

TOGA (Tanaman Obat Keluarga) merupakan upaya untuk meningkatkan pemanfaatan tanaman berkhasiat obat. Selain sebagai sarana untuk menjaga kesehatan masyarakat, toga juga berfungsi sebagai sarana penghijauan, sarana untuk pelestarian alam, saranamemperbaiki gizi, sarana untuk pemerataan pendapatan, sarana penyebaran gerakan penghijauan dan sarana keindahan pekarangan atau lingkungan. Kegiatan Kuliah Kerja Nyata (KKN) ini melalui beberapa tahap yang diawali dengan melakukan pembersihan lahan yang akan diolah sampai pada pembuatan plang TOGA dengan nama latin dari masing masing tanaman pada Kelurahan Jitra.
Kata Kunci: TOGA, Bengkulu, Jitra
 
ABSTRACT
UTILIZATION OF HOME YARD LAND AS A LIVING PHARMACY. TOGA (Family Medicinal Plants) is an effort to increase the use of medicinal plants. Aside from being a means of maintaining public health, the toga also functions as a means of greening, a means of preserving nature, a means of improving nutrition, a means of equalizing income, a means of spreading the greening movement and a means of beautifying yards or the environment. This Field Work Lecture (KKN) activity went through several stages, starting with clearing the land to be processed up to making TOGA signs with the Latin names of each plant in the Jitra Village.
Keywords    : TOGA, Bengkulu, Jitra
PEMANFAATAN LIMBAH DAPUR SEBAGAI PUPUK ORGANIK CAIR (POC) UNTUK BUDIDAYA TANAMAN DI LINGKUNGAN PERKARANGAN MASYARAKAT KELURAHAN SURABAYA KECAMATAN SUNGAI SERUT
Authors: Asmawanti S Dri , Riski Muhammad Hidayat , Cibro Roy Jumadi , Ilahi Fikri Rizqi
Published: September 2023

Pupuk organik adalah pupuk yang dibuat dari bahan tanaman dan atau hewan yang telah mengalami serangkaian proses .Pupuk Organik Cair (POC) merupakan pupuk yang umumnya berasal dari limbah syuran yang sangat mudah ditemukan dan dibuat.Pupuk organic cair dibuat secara alami yakni dengan proses fermentasi,dimana akan menghasilkan pembusukan dari sisa tanaman maupun kotoran hewan.Tujuan pembuatan pupuk organic cair (POC) untuk memanfaatkan limbah dapur atau rumah tangga menjadi hal yang berguna. Pembuatan Pupuk Organik Cair (POC) ini lakukan untuk mengetahui proses yang efektif dalam pembuatan pupuk organik organik cair dengan memanfaatkan sampah organik dari rumah tangga sebagai bahan bakunya dan dengan penambahan EM4 (effective microorganisms).
Kata Kunci: POC, Pupuk Organik, EM4
 
ABSTRACT
 UTILIZATION OF KITCHEN WASTE AS LIQUID ORGANIC FERTILIZER (POC) FOR CULTIVATION OF PLANT IN THE COMMUNITY ENVIRONMENT OF SURABAYA SUB-DISTRICT. A fertilizer is a fertilizer made from materials and or animals that have undergone a process. Liquid Organic Fertilizer (POC) is a fertilizer that generally comes from vegetable waste which is very easy to find and make. Liquid organic fertilizer is made naturally by the fermentation process, which will produce the decay of plant residues and animal waste. The purpose of making liquid organic fertilizer (POC) to utilize kitchen or household waste becomes useful. The manufacture of Liquid Organic Fertilizer (POC) is carried out to determine the effective process in making liquid organic fertilizer by utilizing organic waste from households as raw material and with the addition of EM4 (effective microorganisms).
Keywords: POC, Organic Fertilizer, EM4
PEMBENTUKAN KEGIATAN KELOMPOK BELAJAR KECIL TINGKATAN SEKOLAH DASAR DI MASA PANDEMI
Authors: Lestari Martini Tria , Umar Liya Agustin
Published: September 2023

Pelaksanaan pendidikan di Indonesia dalam masa pandemi Covid-19 mengalami beberapa perubahan yang terlihat nyata. Beberapa upaya yang dilakukan oleh pemerintah untuk mengurangi angka penyebaran covid-19 yang salah satunya dengan menerapkan pelaksanaan kegiatan belajar mengajar dilaksanakan dengan system dalam jaringan (daring) yang diterapkan sejak bulan Maret 2020.  Dalam proses pembelajaran daring, peran orang tua (baik Ayah ataupun Ibu) sangat penting dan sebisa mungkin untuk dapat mendampingi sang Anak, dikarenakan pembelajaran dengan sistem online atau jarak jauh melalui daring sangat dibutuhkan pendampingan bagi anak. Selain itu peran pendampingan orang tua yang juga sebagai guru pendamping apabila ada materi dan tugas sekolah yang guru jelaskan, namun anak masih belum memahami. Sehingga dengan pendampingan orang tua, proses pembelajaran pun akan berjalan dengan baik. Namun cara sistem pembelajaran jarak jauh tidak menutup kemungkinan akan timbul beberapa masalah didalam berlangsungnya proses pembelajaran.
Kata Kunci: Pandemi, Pendidikan, Pendampingan Belajar
 
ABSTRACT
 THE FORMATION OF SMALL GROUP ACTIVITIES AT THE ELEMENTARY SCHOOL LEVEL DURING THE PANDEMIC. The implementation of education in Indonesia during the Covid-19 pandemic underwent several visible changes. Some of the efforts made by the government to reduce the spread of COVID-19, one of which is by implementing the implementation of teaching and learning activities carried out with an online system that has been implemented since March 2020. In the online learning process, the role of parents (both father and mother) is very important, and as much as possible to be able to accompany the child, because learning with an online system or remotely online is very much needed assistance for children. In addition, the role of mentoring parents who are also assistant teachers if there are school materials and assignments that the teacher explains, but the children still do not understand. So, with parental assistance, the learning process will run well. However, the way the distance learning system does not rule out the possibility that some problems will arise in the ongoing learning process.
Keywords: Pandemic, Education, Study Assistance
WORKSHOP PEMBUATAN PUPUK ORGANIK BERBASIS LIMBAH RUMAH TANGGA DI DESA PURWODADI KABUPATEN LAMPUNG SELATAN
Authors: Sylvia Teny , Wandahlia Jambak Agis , Hafid Irawan Ahmad , Ash Shiddiqi Fadleoni Akbar , Permata Mulia Z Alda , Maharani Cynthia , Rahmawati Fadila , Ikhsan Fauzi , Muhammad Ahsani Fairuz , Brigtia Tarigan Eugenia , Auliya Azzahra Adisty , Anggraini Azizah , Nawangsari Defi , Puspita Ningrum Dita
Published: September 2023

Masyarakat di Desa Purwodadi masih belum terlalu peduli dalam mengatasi persoalan limbah, khususnya limbah yang berasal dari rumah tangga. Ketidakpedulian terlihat terlihat dari masih banyaknya warga yang membuang limbah sembarangan seperti di aliran sungai dan saluran irigasi. Limbah tersebut sebenarnya memiliki nilai guna apabila dilakukan pengolahan kembali. Namun, kurangnya pengetahuan masyarakat terutama di desa purwodadi dalam pengolahan limbah, sehingga limbah tersebut hanya dikumpulkan, diangkut, dan dibuang ataupun dibakar.  Salah satu pengolahan limbah organik adalah dapat dijadikan pupuk organik. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk memberi pengetahuan mengenai limbah, pemilahan dan pengolahan limbah menjadi pupuk organik yang nantinya dapat digunakan untuk memupuk tanaman baik yang ada di kebun maupun  di pekarangan rumah. Pengabdian ini dilakukan mahasiswa dalam rangkaian kegiatan kuliah kerja nyata (KKN) untuk mendukung program zero waste yang dicanangkan oleh pemerintah. Kegiatan pengabdian ini diawali dengan sosialisasi mengenai limbah, cara memilah limbah, pengolahan limbah, pupuk organik dan komposter. Lalu dilanjutkan dengan demonstrasi pembuatan pupuk organik. Hasil kegiatan demonstrasi kepada warga desa memberikan respon yang positif. Hal ini dapat dilihat dari antusias warga dalam mengikuti kegiatan workshop, baik pada kegiatan pemberian materi maupun demonstrasi pembuatan pupuk organik.

 

Kata Kunci : Desa Purwodadi, Kuliah Kerja Nyata, Limbah, Pupuk Organik, Zero Waste.
David Prieto García-Seco (2021). «Un eslabón recuperado de la lexicografía española. La reimpresión retocada del “Diccionario” académico de 1780», pról. de Pedro Álvarez de Miranda
Authors: Díaz Rosales Raúl
Published: September 2023

David Prieto García-Seco (2021). «Un eslabón recuperado de la lexicografía española. La reimpresión retocada del “Diccionario” académico de 1780». Pról. de Pedro Álvarez de Miranda. Madrid, Visor (col. Visor Lingüística, n.º 30), 124 pp. ISBN: 978-84-9895-633-7
María Águeda Moreno Moreno (dir./coord.) (2020). «Un mundo en retazos léxicos. Ambientes lingüísticos en la literatura oral de Jaén»
Authors: Cabello Pino Manuel
Published: September 2023

María Águeda Moreno Moreno (dir./coord.) (2020). «Un mundo en retazos léxicos. Ambientes lingüísticos en la literatura oral de Jaén», Madrid/Fráncort del Meno, Iberoamericana/Vervuert (Lengua y Sociedad en el Mundo Hispánico), 2020, 153 pp. ISBN 978-84-9192-196-7 (Iberoamericana). ISBN 978-3-96869-116-9 (Vervuert). ISBN 978-3-96869-123-7.
A multi-branch network to detect post-operative complications following hip arthroplasty on X-ray images
Authors: Guo Sijia , Zhang Jiping , Li Huiwu , Zhang Jingwei , Cheng Cheng-Kung
Published: September 2023

Background: Postoperative complications following total hip arthroplasty (THA) often require revision surgery. X-rays are usually used to detect such complications, but manually identifying the location of the problem and making an accurate assessment can be subjective and time-consuming. Therefore, in this study, we propose a multi-branch network to automatically detect postoperative complications on X-ray images.

Methods: We developed a multi-branch network using ResNet as the backbone and two additional branches with a global feature stream and a channel feature stream for extracting features of interest. Additionally, inspired by our domain knowledge, we designed a multi-coefficient class-specific residual attention block to learn the correlations between different complications to improve the performance of the system.

Results: Our proposed method achieved state-of-the-art (SOTA) performance in detecting multiple complications, with mean average precision (mAP) and F1 scores of 0.346 and 0.429, respectively. The network also showed excellent performance at identifying aseptic loosening, with recall and precision rates of 0.929 and 0.897, respectively. Ablation experiments were conducted on detecting multiple complications and single complications, as well as internal and external datasets, demonstrating the effectiveness of our proposed modules.

Conclusion: Our deep learning method provides an accurate end-to-end solution for detecting postoperative complications following THA.
Economic resilience during COVID-19: the case of food retail businesses in Seattle, Washington
Authors: Sun Feiyang , Whittington Jan , Ning Siman , Proksch Gundula , Shen Qing , Dermisi Sofia
Published: September 2023

The first year of COVID-19 tested the economic resilience of cities, calling into question the viability of density and the essential nature of certain types of services. This study examines built environment and socio-economic factors associated with the closure of customer-facing food businesses across urban areas of Seattle, Washington. The study covers 16 neighborhoods (44 census block groups), with two field audits of businesses included in cross-sectional studies conducted during the peak periods of the pandemic in 2020. Variables describing businesses and their built environments were selected and classified using regression tree methods, with relationships to business continuity estimated in a binomial regression model, using business type and neighborhood socio-demographic characteristics as controlled covariates. Results show that the economic impact of the pandemic was not evenly distributed across the built environment. Compared to grocery stores, the odds of a restaurant staying open during May and June were 24%, only improving 10% by the end of 2020. Density played a role in business closure, though this role differed over time. In May and June, food retail businesses were 82% less likely to remain open if located within a quarter-mile radius of the office-rich areas of the city, where pre-pandemic job density was greater than 95 per acre. In November and December, food retail businesses were 66% less likely to remain open if located in areas of residential density greater than 23.6 persons per acre. In contrast, median household income and percentage of non-Asian persons of color were positively and significantly associated with business continuity. Altogether, these findings provide more detailed and accurate profiles of food retail businesses and a more complete impression of the spatial heterogeneity of urban economic resilience during the pandemic, with implications for future urban planning and real estate development in the post-pandemic era.
Mimicking lipolytic, adipogenic, and secretory capacities of human subcutaneous adipose tissue by spheroids from distinct subpopulations of adipose stromal/stem cells
Authors: Côrtes Isis , Alves Gutemberg , Claudio-Da-Silva Cesar , Baptista Leandra Santos
Published: September 2023

Background: Adipose tissue engineering may provide 3D models for the understanding of diseases such as obesity and type II diabetes. Recently, distinct adipose stem/stromal cell (ASC) subpopulations were identified from subcutaneous adipose tissue (SAT): superficial (sSAT), deep (dSAT), and the superficial retinacula cutis (sRC). This study aimed to test these subpopulations ASCs in 3D spheroid culture induced for adipogenesis under a pro-inflammatory stimulus with lipopolysaccharide (LPS).

Methods: The samples of abdominal human subcutaneous adipose tissue were obtained during plastic aesthetic surgery (Protocol 145/09).

Results: ASC spheroids showed high response to adipogenic induction in sSAT. All ASC spheroids increased their capacity to lipolysis under LPS. However, spheroids from dSAT were higher than from sSAT (p = 0.0045) and sRC (p = 0.0005). Newly formed spheroids and spheroids under LPS stimulus from sSAT showed the highest levels of fatty acid-binding protein 4 (FABP4) and CCAAT/enhancer-binding protein-α (C/EBPα) mRNA expression compared with dSAT and sRC (p < 0.0001). ASC spheroids from sRC showed the highest synthesis of angiogenic cytokines such as vascular endothelial growth factor (VEGF) compared with dSAT (p < 0.0228). Under LPS stimulus, ASC spheroids from sRC showed the highest synthesis of pro-inflammatory cytokines such as IL-6 compared with dSAT (p < 0.0092).

Conclusion: Distinct physiological properties of SAT can be recapitulated in ASC spheroids. In summary, the ASC spheroid from dSAT showed the greatest lipolytic capacity, from sSAT the greatest adipogenic induction, and sRC showed greater secretory capacity when compared to the dSAT. Together, all these capacities form a true mimicry of SAT and hold the potential to contribute for a deeper understanding of cellular and molecular mechanisms in healthy and unhealthy adipose tissue scenarios or in response to pharmacological interventions.
Estimation of cAMP binding in hippocampus CA1 field by a fluorescent probe
Authors: Mucignat-Caretta Carla , Caretta Antonio
Published: September 2023

The hippocampus is an allocortex structure involved in many complex processes, from memory formation to spatial navigation. It starts developing during prenatal life but acquires its adult functional properties around the peripubertal age, in both humans and mice. Such prolonged maturation is accompanied by structural changes in microcircuitry and functional changes involving biochemical and electrophysiological events. Moreover, hippocampus undergoes plasticity phenomena throughout life. In murine rodents, the most relevant maturation steps in Cornu Ammonis 1 (CA1) hippocampal subfield occur during the third-fourth weeks of life. During this period, also the expression and localization of cAMP-dependent protein kinases (PKA) refines: many regulatory (R1A) PKA clusters appear, bound to the cytoskeleton. Here the binding characteristics of R1A are determined in CA1 by using confocal microscopy. Apparently, two binding sites are present with no evidence of cooperativity. Equilibrium dissociation constant is estimated around 22.9 nM. This value is lower from that estimated for R1A in soluble form, suggesting a different binding site conformation or accessibility in the tissue. The method described here may be useful to track the developmental changes in binding activity, which affects cAMP availability at selected intracellular microzones. Possible relations with functional consequences are discussed.
Ni–Rh-based bimetallic conductive MOF as a high-performance electrocatalyst for the oxygen evolution reaction
Authors: Zu Shu , Zhang Huan , Zhang Tong , Zhang Mingdao , Song Li
Published: September 2023

Metal–organic frameworks (MOFs) have recently been considered the promising catalysts due to their merits of abundant metal sites, versatile coordination groups, and tunable porous structure. However, low electronic conductivity of most MOFs obstructs their direct application in electrocatalysis. In this work, we fabricate an Ni–Rh bimetallic conductive MOF ([Ni2.85Rh0.15(HHTP)2]n/CC) grown in situ on carbon cloth. Abundant nanopores in the conductive MOFs expose additional catalytic active sites, and the advantageous 2D π-conjugated structure helps accelerate charge transfer. Owing to the introduction of Rh, [Ni2.85Rh0.15(HHTP)2]n/CC exhibited substantially improved oxygen evolution reaction (OER) activity and exhibited only an overpotential of 320 mV to achieve the current density of 20 mA cm-2. The remarkable OER performance confirmed by the electrochemical tests could be ascribed to the synergistic effect caused by the doped Rh together with Ni in [Ni2.85Rh0.15(HHTP)2]n/CC, thereby exhibiting outstanding electrocatalytic performance.
Circular RNAs in vascular diseases
Authors: Liu Qiaoyuan , Wang Yaofeng , Zhang Tinghong , Fang Jianwen , Meng Shu
Published: September 2023

Vascular diseases are the leading cause of morbidity and mortality worldwide and are urgently in need of diagnostic biomarkers and therapeutic strategies. Circular RNAs (circRNAs) represent a unique class of RNAs characterized by a circular loop configuration and have recently been identified to possess a wide variety of biological functions. CircRNAs exhibit exceptional stability, tissue specificity, and are detectable in body fluids, thus holding promise as potential biomarkers. Their encoding function and stable gene expression also position circRNAs as an excellent alternative to gene therapy. Here, we briefly review the biogenesis, degradation, and functions of circRNAs. We summarize circRNAs discovered in major vascular diseases such as atherosclerosis and aneurysms, with a particular focus on molecular mechanisms of circRNAs identified in vascular endothelial cells and smooth muscle cells, in the hope to reveal new directions for mechanism, prognosis and therapeutic targets of vascular diseases.
The roles of Black women principals: evidence from two national surveys
Authors: Cheng Albert , Coady Emily , Maranto Robert
Published: September 2023

While two-thirds of Black principals are female, the extant research on Black female principals is almost entirely qualitative. Using data from the 2017–2018 National Teacher and Principal Survey (n = 7,170 with 450 Black female principals) and the 2011–2012 Schools and Staffing Survey (n = 7,510, with 360 Black female principals), we quantitatively examine the career paths, reported influence, and reported time use of Black female principals compared to other principals. Black female principals are relatively less likely than Black male principals to have experience as athletic coaches, and less likely to have non-education management experience. Relative to non-Black female principals, Black female principals are less likely to have experience as curriculum directors. Relative to other principals, Black female principals generally report having comparable influence over their schools, while spending somewhat more time on parent interactions, suggestive of roles representing minority parents. We discuss implications and directions for future research.
Influence of a groove-structured vortex generator on the drag reduction characteristics of a multiphase pump
Authors: Han Wei , Yang Xiang , Zhang Jing , Xiao Mingzhen , Yan Lumin , Zhou Juping , Gu Zhenye , Yang Shiqi
Published: September 2023

The oil–gas mixture pump significantly contributes to marginal oil field extraction and remote transportation of deep-sea oil. Nevertheless, during the operation of the mixture pump, it is inevitable to encounter problems like the separation of the mixed media from the hydraulic components as well as the gas phase from the liquid phase, which leads to enhancing the flow resistance of the mixed media. Therefore, this study investigates the influence of a groove-structure vortex generator on the drag reduction characteristics of a helical axial-flow gas–liquid multiphase pump under the design flow rate condition and various inlet gas content rates. The findings show that the vortex generator with diverse groove depths can prevent the separation of the mixed media from the blade suction surface effectively and minimize the flow resistance of the media in the 1/10 of the blade inlet. In particular, excellent drag reduction results were gained with a maximum drag reduction rate of 36.7% when the relative depth was 3/40. In addition, the efficiency of the mixture pump increased by a maximum of 2.1%, and the head increased by a maximum of 4.3%. The significance of this study lies in its potential to further optimize the design and performance of gas–liquid multiphase pumps. It provides new insights into the design and application of vortex generators. It offers robust support for the optimization and enhancement of gas–liquid multiphase pumps.
Patent signal and financing constraints: a life cycle perspective and evidence from new energy industry
Authors: Li Qianjie , Pang Liyuan , Yin Shi
Published: September 2023

Based on the data of China’s new energy listed companies, this paper empirically studies the impact of the patent signal on the financing constraints of new energy enterprises and its mechanism. The results show that: (i) Both the invention patent application and the non-invention patent application can play a signaling role to alleviate the financing constraints of new energy enterprises; (ii) Analyst attention plays an intermediary role between the patent signal and the financing constraints of new energy enterprises. Compared with non-invention patents, analyst attention plays a more vital intermediary role on invention patents; (iii) Patent signal can alleviate the financing constraints of new energy enterprises in the growth and maturity stages by increasing analyst attention but has no apparent effect on the recession period; (iv) Compared with non-main board listed and small-scale new energy enterprises, patent signal has a more substantial effect on alleviating the financing constraints of main board listed and large-scale new energy enterprises.
Vulnerability and risk assessment mapping of Bhitarkanika national park, Odisha, India using machine-based embedded decision support system
Authors: Mohanty Shantakar , Mustak Sk. , Singh Dharmaveer , Van Hoang Thanh , Mondal Manishree , Wang Chun-Tse
Published: September 2023

The vulnerability and flood risk assessment of Bhitarkanika National Park in Odisha, India, was conducted using a data-driven approach and a machine-based embedded decision support system. The park, located in the estuaries of the Brahmani, Baitarani, Dharma, and Mahanadi river systems, is home to India’s second-largest mangrove environment and the world’s most active and diverse saline wetland. To evaluate its vulnerability and risk, various threats were considered, with a focus on floods. Satellite imageries, such as Landsat 8 OLI, SRTM digital elevation model, open street map, Google pro image, reference map, field survey, and other ancillary data, were utilized to develop vulnerability and risk indicators. These indicators were then reclassified into ‘Cost’ and ‘Benefit’ categories for better understanding. The factors were standardized using the max-min standardization method before being fed into the vulnerability and risk model. Initially, an analytical hierarchy approach was used to develop the model, which was later compared with machine learning algorithms (e.g., SVM) and uncertainty analysis indices (e.g., overall accuracy, kappa, map quality, etc.). The results showed that the SVM-RBF machine learning algorithm outperformed the traditional geostatistical model (AHP), with an overall accuracy of 99.54% for flood risk mapping compared to AHP’s 91.12%. The final output reveals that a large area of Bhitarkanika National park falls under high flood risk zone. The Eastern coastal regions of Govindapur, Kanhupur, Chinchri, Gobardhanpur and Barunei fall under high risk zone of tidal floods, The Northern and western regions of Ramachandrapur, Jaganathpur, Kamalpur, Subarnapur, Paramanandapur, etc., Fall under high risk region of riverine floods. The study also revealed that the areas covered with mangroves have a higher elevation and hence are repellent to any kind of flood. In the event of a flood high priority conservation measures should be taken along all high flood risk areas. This study is helpful for decision-making and carrying out programs for the conservation of natural resources and flood management in the national park and reserve forest for ecological sustainability to support sustainable development goals (e.g., SDGs-14, 15).
Optimized layout of supporting facilities in mountainous industrial parks: a case study of Chongqing Dadi Industrial Park
Authors: Duan Ran , Tang Rui , Wang Zhigang , Yang Jiyi , Su Jiafu
Published: September 2023

Industrial parks play a pivotal role in driving urban economic growth in China, particularly in light of the country's extensive mountainous terrain. Effective arrangement of supporting facilities within these parks is crucial for steering industries towards high-quality development. However, the intricate topography of mountainous regions presents challenges in devising optimal layouts for these facilities. This article adopts a user-centric perspective to investigate the impact of mountainous terrain on user fatigue within industrial parks. We employ equivalent coefficient methods to establish a correlation between undulating paths in mountainous terrain and flat paths. This correlation serves as the foundation for a visual analytical tool designed to facilitate the rational placement of supporting facilities in mountainous industrial parks. To validate our approach, we conduct an empirical analysis of the supporting facility layout at Chongqing Dadi Industrial Park. The insights gleaned from our study provide a basis for optimizing the placement of supporting facilities in mountainous industrial parks, enhancing user experiences and aligning with urban growth trajectories. In conclusion, our research offers dual benefits: firstly, it provides a scientific framework for guiding the rational layout of supporting facilities in mountainous industrial parks, addressing the challenges posed by complex terrain. Secondly, it offers practical insights into the comprehensive planning and design of these parks, promoting sustainable urban and economic growth. Our research thus emerges as a valuable resource for the advancement and optimization of mountainous industrial parks in China.
Assessment of timber value and carbon credits provided by pure and mixed forests in Taiwan
Authors: Lin Yow-Ru , Liu Wan-Yu
Published: September 2023

Introduction

Clear-cutting an even-aged pure forest is a conventional forest operation for wood production. However, this type of operation is unsuitable for sustainable management with multiple disadvantages. By contrast, mixed forests are a forestation strategy that accommodates diversity. This study aims to assess and compare the timber value and carbon credits of a pure forest and a mixed forest, which is transformed from a pure forest. Two alternative options in managing plantations of pure forest (with Cryptomeria japonica) and mixed forest (with part of C. japonica cut and Cinnamomum camphora replanted) are evaluated considering both timber value and carbon credits. Scenarios with various harvesting intensities and carbon payments were also considered.

Method

A theoretical model was applied, converting pure forest into mixed forest, then two species are cut or replanted in the second round. By contrast, in the pure forest situation, the setting for the second rotation period is a pure forest for 20 years. The model was applied in a simulation experiment and the study area is Taiwan. The selected tree species are representative and have been chosen for analysis.

Results

This study showed that even-aged pure forests had higher wood sales and lower carbon payments than uneven-aged mixed forests. The net present value from market value would be from −255,403 NTD ha−1 to −74,134 NTD ha−1 and that from carbon value will be from 156,076 NTD ha−1 to 208,937 NTD ha−1.

Discussion

This study showed strategies by which values could be increased during the transition from an even-aged pure forest to a mixed forest. Feasible methods included reducing the costs of reforestation, management, and cutting while increasing carbon prices to increase profits from wood and carbon income. A higher harvesting intensity could contribute to greater production and increase the area available for planting, resulting in greater profits from wood and carbon income.
Enhancing biosecurity against virus disease threats to Australian grain crops: current situation and future prospects
Authors: Maina Solomon , Jones Roger A. C.
Published: September 2023

Australia is a major grain exporter, and this trade makes an important contribution to its economy. Fortunately, it remains free of many damaging virus diseases and virus vectors found elsewhere. However, its crop biosecurity is under increasing pressure from global ecological, climatic, and demographic challenges. Stringent biosecurity and plant health programs safeguard Australian grain production from damaging virus and virus vector incursions entering via different pathways. These programs formerly relied upon traditional testing procedures (indicator hosts, serology, PCRs) to intercept incoming virus-contaminated plant material. Recently, the integration of rapid genomic diagnostics innovation involving High Throughput Sequencing (HTS) smart tools into sample testing schedules is under exploration to improve virus testing accuracy, efficiency, and cost effectiveness under diverse circumstances. This process includes evaluating deployment of Illumina and Oxford Nanopore Technology shotgun sequencing. It also includes evaluating targeted viral genome HTS and virus vector metabarcoding approaches. In addition, using machine learning and deep learning capacities for big data analyses and remote sensing technologies will improve virus surveillance. Tracking damaging virus variants will be improved by surveillance networks which combine virus genomic-surveillance systems with an interoperable virus database. Sequencing Australian virus specimen collections will help ensure the accuracy of virus identifications based solely on genetic information. Enhancing routine diagnosis and data collection using these innovations will improve post entry virus interception and background virus and vector surveillance. This will help reduce the frequency of new incursions, improve virus management during eradication, containment and other plant health activities, and achieve more profitable Australian grain production.
Research progress of NF-κB signaling pathway and thrombosis
Authors: Wang Zilong , Fang Chucun , Yao Mengting , Wu Dongwen , Chen Maga , Guo Tianting , Mo Jianwen
Published: September 2023

Venous thromboembolism is a very common and costly health problem. Deep-vein thrombosis (DVT) can cause permanent damage to the venous system and lead to swelling, ulceration, gangrene, and other symptoms in the affected limb. In addition, more than half of the embolus of pulmonary embolism comes from venous thrombosis, which is the most serious cause of death, second only to ischemic heart disease and stroke patients. It can be seen that deep-vein thrombosis has become a serious disease affecting human health. In recent years, with the deepening of research, inflammatory response is considered to be an important pathway to trigger venous thromboembolism, in which the transcription factor NF-κB is the central medium of inflammation, and the NF-κB signaling pathway can regulate the pro-inflammatory and coagulation response. Thus, to explore the mechanism and make use of it may provide new solutions for the prevention and treatment of thrombosis.
Metabolic profiling of Apostichopus japonicus body wall exposed to a typical type of PBDEs: potential health risks and impact on sea cucumber health
Authors: Ding Kui , Zhuo Pengji , Ge Meiling , Liao Xiaomei , Mo Jing , Liu Shilin , Xu Qinzeng , Zhang Xuelei
Published: September 2023

Introduction

Sea cucumbers are cultivated mainly for their valuable body wall. Polybrominated diphenyl ethers are common persistent pollutants in sea waters with known impacts on aquatic animals nonetheless not yet studied for the body wall of sea cucumbers.

Methods

Using ltra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Triple-TOF-MS), we investigated the metabolic impact of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) on the body wall of Apostichopus japonicus. etabolite changes and metabolic pathway alterations were assessed in response to three distinct concentrations of BDE-47: 0.1 µg/L, 1.0 µg/L, and 10.0 µg/L.

REsults

Exposure to BDE-47 led to notable alterations in the metabolic profiles of the body wall. A total of 95~102 metabolites in the 0.1 ~ 10.0 µg/L BDE-47 treated group were altered significantly, and various disrupted metabolic pathways were identified and characterized. These metabolites and metabolic pathways were mainly involved in lipid metabolism, energy metabolism, immunity, oxidative stress, inflammation, and neurotoxicity.

Discussion

The findings of our study shed light on the potential health risks that polybrominated diphenyl ethers present to sea cucumbers. This underscores the imperative for both researchers and policymakers to delve deeper into further investigations and studies. These results indicate the necessity for enhanced monitoring and management practices within the sea cucumber aquaculture industry to mitigate the impact of these persistent organic pollutants and protect the health and safety of this valuable resource.
Adverse drug events in Chinese elder inpatients: a retrospective review for evaluating the efficiency of the Global Trigger Tool
Authors: Yu Nan , Wu Liuyun , Yin Qinan , Du Shan , Liu Xinxia , Wu Shan , Tong Rongsheng , Yan Junfeng , Bian Yuan
Published: September 2023

Background

Elderly patients frequently experience a high incidence of adverse drug events (ADEs) due to the coexistence of multiple diseases, the combination of various medications, poor medication compliance, and other factors. Global Trigger Tool (GTT) is a new method for identifying ADEs, introducing the concept of a trigger, that is, clues including abnormal laboratory values, reversal drugs, and clinical symptoms that may suggest ADEs, and specifically locating information related to ADEs in the medical record to identify ADEs. The aim of this study was to establish a GTT-based trigger tool for adverse medication events in elderly patients and to investigate the risk variables associated with such events.

Methods

The triggers were identified by reviewing the frequency of ADEs in elderly patients in Sichuan, China, retrieving relevant literature, and consulting experts. A retrospective analysis was carried out to identify adverse medication occurrences among 480 elderly inpatients in Sichuan People’s Hospital.

Results

A total of 56 ADEs were detected in 51 patients (10.62%), 13.04 per 1,000 patient days, and 11.67 per 100 admissions. The overall positive predictive value (PPV) of the triggers was 23.84, and 94.64% of ADEs caused temporary injury. Gastrointestinal system injury (27.87%) and metabolic and nutritional disorders (24.53%) were the primary organ-systems affected by ADEs. The majority of ADEs were caused by drugs used to treat cardiovascular diseases. 71.43% of ADE occurred within 2 days of administration and the risk factor analysis of ADE revealed that the number of medicines had a significant correlation.

Conclusion

This study demonstrated GTT’s value as a tool for ADEs detection in elderly inpatients in China. It enhances the level of medication management and comprehensively reflects the situation of ADE of the elderly.