bluuebunny/crossref_metadata_2025 huggingface dataset:
Combining Homologous Recombination-Deficient Testing and Functional RAD51 Analysis Enhances the Prediction of Poly(ADP-Ribose) Polymerase Inhibitor Sensitivity
Authors: Korsholm Lea M. , Kjeldsen Maj , Perino Lorenzo , Mariani Luca , Nyvang Gitte-Bettina , Kristensen Elisabeth , Bagger Frederik O. , Mirza Mansoor Raza , Rossing Maria
Published: March 2024

PURPOSE

To meet the urgent need for accessible homologous recombination-deficient (HRD) test options, we validated a laboratory-developed test (LDT) and a functional RAD51 assay to assess patients with ovarian cancer and predict the clinical benefit of poly(ADP-ribose) polymerase inhibitor therapy.

METHODS

Optimization of the LDT cutoff and validation on the basis of samples from 91 patients enrolled in the ENGOT-ov24/NSGO-AVANOVA1&2 trial (ClinicalTrials.gov identifier: NCT02354131 ), previously subjected to commercial CDx HRD testing (CDx). RAD51 foci analysis was performed and tumors with ≥five foci/nucleus were classified as RAD51-positive (homologous recombination-proficient).

RESULTS

The optimal LDT cutoff is 54. Comparing CDx genome instability score and LDT HRD scores show a Spearman's correlation of rho = 0.764 ( P < .0001). Cross-tabulation analysis shows that the sensitivity of the LDT HRD score is 86% and of the LDT HRD status is 91.8% (Fisher's exact test P < .001). Survival analysis on progression-free survival (PFS) of LDT-assessed patients show a Cox regression P < .05. RAD51 assays show a correlation between low RAD51 foci detection (<20% RAD51+ cells) and significantly prolonged PFS ( P < .001).

CONCLUSION

The robust concordance between the open standard LDT and the CDx, especially the correlation with PFS, warrants future validation and implementation of the open standard LDT for HRD testing in diagnostic settings.
Effect of Impaired Awareness of Hypoglycemia on Glucose Decline During and After Exercise in the T1DEXI Study
Authors: Kamimoto Jorge L Jo , Li Zoey , Gal Robin L , Castle Jessica R , Doyle Francis J , Jacobs Peter G , Martin Corby K , Beck Roy W , Calhoun Peter , Riddell Michael C , Rickels Michael R
Published: March 2024

Context

Adults with type 1 diabetes (T1D) face the necessity of balancing the benefits of exercise with the potential hazards of hypoglycemia.

Objective

This work aimed to assess whether impaired awareness of hypoglycemia (IAH) affects exercise-associated hypoglycemia in adults with T1D.

Methods

We compared continuous glucose monitoring (CGM)-measured glucose during exercise and for 24 hours following exercise from 95 adults with T1D and IAH (Clarke score ≥4 or ≥1 severe hypoglycemic event within the past year) to 95 “aware” adults (Clarke score ≤2 and no severe hypoglycemic event within the past year) matched on sex, age, insulin delivery modality, and glycated hemoglobin A1c. A total of 4236 exercise sessions, and 1794 exercise days and 839 sedentary days, defined as 24 hours following exercise or a day without exercise, respectively, were available for analysis.

Results

Participants with IAH exhibited a nonsignificant trend toward greater decline in glucose during exercise compared to “aware” (−21 ± 44 vs −19 ± 43 mg/dL [−1.17 ± 2.44 vs −1.05 ± 2.39 mmol/L], adjusted group difference of −4.2 [95% CI, −8.4 to 0.05] mg/dL [−0.23 95% CI, −.47 to 0.003 mmol/L]; P = .051). Individuals with IAH had a higher proportion of days with hypoglycemic events below 70 mg/dL [3.89 mmol/L] (≥15 minutes <70 mg/dL [<3.89 mmol/L]) both on exercise days (51% vs 43%; P = .006) and sedentary days (48% vs 30%; P = .001). The increased odds of experiencing a hypoglycemic event below 70 mg/dL (<3.89 mmol/L) for individuals with IAH compared to “aware” did not differ significantly between exercise and sedentary days (interaction P = .36).

Conclusion

Individuals with IAH have a higher underlying risk of hypoglycemia than “aware” individuals. Exercise does not appear to differentially increase risk for hypoglycemia during the activity, or in the subsequent 24 hours for IAH compared to aware individuals with T1D.
Dynamics of IGF Signaling During the Ovulatory Peak in Women Undergoing Ovarian Stimulation
Authors: Bøtkjær Jane Alrø , Poulsen Liv la Cour , Noer Pernille Rimmer , Grøndahl Marie Louise , Englund Anne Lis Mikkelsen , Franks Stephen , Hardy Kate , Oxvig Claus , Andersen Claus Yding
Published: March 2024

Context

Insulin-like growth factor (IGF) signaling is known to affect human ovarian follicular function during growth and development. However, the role of the IGF system is unknown during the ovulatory peak, which is characterized by profound changes in granulosa cell (GCs) mitosis and function.

Objective

How is the IGF system expressed and regulated during the midcycle surge in women?

Methods

Follicular fluid (FF) and GCs were collected during the ovulatory peak from 2 specific time points. One sample was obtained before oocyte pickup (OPU): before ovulation trigger (OT) (T = 0 hours) or at 12, 17, or 32 hours after OT, and 1 sample was obtained at OPU 36 hours after OT. Fifty women undergoing ovarian stimulation at a university hospital were included. Gene expression profiles were assessed by microarray analysis of GCs. IGF-related proteins in the FF were assessed by immunoassay or by determination of activity with a proteinase assay.

Results

Gene expression of proteins promoting IGF activity (ie, IGF2, PAPP-A, and IRS1) together with proliferation markers were downregulated on a transcriptional level in GCs after OT, whereas proteins inhibiting the IGF signal (ie, IGFBPs, IGF2, and STC1) were upregulated. STC1 gene expression and protein levels were greatly upregulated after OT with a parallel steep downregulation of PAPP-A proteolytic activity.

Conclusion

These data suggest that downregulation of IGF signaling mediated by increased STC1 expression is instrumental for the sudden cessation in GC proliferation and onset of differentiation during the ovulatory peak.
Art in the First Screen Age: László Moholy-Nagy and the Affordances of Surfaces, Canvases, and Scrims
Authors: Elcott Noam M.
Published: March 2024

Unlike English or French, early twentieth-century German did not adopt a single term for “screen.” Instead, a range of terms—and practices—proliferated. This essay explores three terms and practices developed especially within avant-garde circles: Fläche (surface), Leinwand (canvas), and Schirm (scrim). Fläche was championed as material and real; Leinwand was dismissed as immaterial and illusionistic. Schirm, however, challenged these oppositions. Rather than succumb to the traditional avant-garde choice between material reality and immaterial illusion, László Moholy-Nagy advanced a third option: the immaterial reality of Schirme, that is, phantasmagoric presences in our real time and real space.
Reconsidering Photographic Temporality through Piotr Uklański’s Nazis
Authors: Magilow Daniel H.
Published: March 2024

In The Nazis (1998) and its sequel, Real Nazis (2017), the Polish American artist Piotr Uklański creates glossy photographic assemblages of real and fictional Nazis, which critics have generally interpreted by turns as critiquing or participating in the culture industry’s fascination with and glamourization of Nazism. However, the formal mechanisms of Uklański’s work remain undertheorized. This essay offers a reading of The Nazis and Real Nazis that locates the aesthetic politics of these two products of the “perpetrator turn” in Holocaust studies and memory studies in the ways they manipulate assumptions about photographs’ temporality. Photographic theorists like Siegfried Kracauer, Susan Sontag, André Bazin, and Roland Barthes famously conceptualized photographic time through the category of grammatical tense and on examples of individual still images rather than photographic series. This essay builds on those theories by applying Peter Wollen’s work about narrative and grammatical aspect, which concerns the completedness or duration of what photographs depict, to argue that Uklański’s Nazi projects are more adequately explained as incomplete photographic narratives. By occluding viewers’ expectations about the aspect of photography, The Nazis and Real Nazis critically renarrate Nazism not as a completed historical trauma but as alive today amid a worldwide resurgence of right-wing populism.
Want doctors to use VR simulation? Make it mandatory, accessible, educationally valuable, and enjoyable!
Authors: Houlden Riki , Crichton Fiona
Published: March 2024

Background Virtual reality (VR) simulation training is mandatory for postgraduate year 1-2 doctors at the author’s hospital trust. Despite this, a preceding quantitative study demonstrated uptake below required levels. While the educational value of VR simulation has been highlighted, little attention has been paid to participant utilisation in postgraduate curricula. With the increasing development and incorporation of VR-based clinical education, it is essential to understand the factors influencing how frequently postgraduate doctors utilise it so that its potential can be maximised. Methods A qualitative study design was employed. All 108 postgraduate year 1-2 doctors from the 2020-21 training year were invited for a semi-structured interview. Interviews continued until data saturation was reached in the form of informational redundancy. Reflexive thematic analysis was conducted. Results A total of 17 interviews were conducted. Four main themes that influenced participation in VR simulation were identified: (1) the mandatory nature encouraged participation but led to negative perceptions as a tick-box exercise; (2) there were multiple challenges to accessing the resource; (3) the scenarios were felt to have limited educational value; and (4) there was untapped potential in drawing benefits from VR as an enjoyable leisure activity. Conclusions Recommendations from these findings include: (1) VR simulation should be mandatory but with a degree of learner autonomy; (2) sessions should be integrated into doctors’ rotas as protected time; (3) more challenging scenarios ought to be created aligned with postgraduate courses, examinations, and specialty training, and (4) presented as a difficulty level system akin to gaming experiences.
Pharmacokinetics of antitubercular drugs in patients hospitalized with HIV-associated tuberculosis: a population modeling analysis
Authors: Abdelgawad Noha , Chirehwa Maxwell , Schutz Charlotte , Barr David , Ward Amy , Janssen Saskia , Burton Rosie , Wilkinson Robert J. , Shey Muki , Wiesner Lubbe , McIlleron Helen , Maartens Gary , Meintjes Graeme , Denti Paolo
Published: March 2024

Background Early mortality among hospitalized HIV-associated tuberculosis (TB/HIV) patients is high despite treatment. The pharmacokinetics of rifampicin, isoniazid, and pyrazinamide were investigated in hospitalized TB/HIV patients and a cohort of outpatients with TB (with or without HIV) to determine whether drug exposures differed between groups. Methods Standard first-line TB treatment was given daily as per national guidelines, which consisted of oral 4-drug fixed-dose combination tablets containing 150 mg rifampicin, 75 mg isoniazid, 400 mg pyrazinamide, and 275 mg ethambutol. Plasma samples were drawn on the 3rd day of treatment over eight hours post-dose. Rifampicin, isoniazid, and pyrazinamide in plasma were quantified and NONMEM® was used to analyze the data. Results Data from 60 hospitalized patients (11 of whom died within 12 weeks of starting treatment) and 48 outpatients were available. Median (range) weight and age were 56 (35 - 88) kg, and 37 (19 - 77) years, respectively. Bioavailability and clearance of the three drugs were similar between TB/HIV hospitalized and TB outpatients. However, rifampicin’s absorption was slower in hospitalized patients than in outpatients; mean absorption time was 49.9% and 154% more in hospitalized survivors and hospitalized deaths, respectively, than in outpatients. Higher levels of conjugated bilirubin correlated with lower rifampicin clearance. Isoniazid’s clearance estimates were 25.5 L/h for fast metabolizers and 9.76 L/h for slow metabolizers. Pyrazinamide’s clearance was more variable among hospitalized patients. The variability in clearance among patients was 1.70 and 3.56 times more for hospitalized survivors and hospitalized deaths, respectively, than outpatients. Conclusions We showed that the pharmacokinetics of first-line TB drugs are not substantially different between hospitalized TB/HIV patients and TB (with or without HIV) outpatients. Hospitalized patients do not seem to be underexposed compared to their outpatient counterparts, as well as hospitalized patients who survived vs who died within 12 weeks of hospitalization.
The genome sequence of spotted medick, Medicago arabica (L.) Huds. (Fabaceae)
Authors: Christenhusz Maarten J. M. , Fay Michael F. , Leitch Ilia J. ,   Royal Botanic Gardens Kew Genome Acquisition Lab,   Plant Genome Sizing collective,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: March 2024

We present a genome assembly from an individual Medicago arabica (the spotted medick; Tracheophyta; Magnoliopsida; Fabales; Fabaceae). The genome sequence is 515.5 megabases in span. Most of the assembly is scaffolded into 8 chromosomal pseudomolecules. The mitochondrial and plastid genome assemblies have lengths of 324.47 kilobases and 125.07 kilobases in length, respectively.
The genome sequence of the wood-carving leafcutter bee, Megachile ligniseca (Kirby, 1802)
Authors: Crowley Liam M. , Falk Steven ,   University of Oxford and Wytham Woods Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: March 2024

We present a genome assembly from an individual female Megachile ligniseca (the wood-carving leafcutter bee; Arthropoda; Insecta; Hymenoptera; Megachilidae). The genome sequence is 290.0 megabases in span. Most of the assembly is scaffolded into 16 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 23.71 kilobases in length. Gene annotation of this assembly on Ensembl 11,722 protein coding genes.
The genome sequence of the ten-spot ladybird, Adalia decempunctata (Linnaeus, 1758)
Authors: Crowley Liam M. , Roy Helen E. , Brown Peter M.J. ,   University of Oxford and Wytham Woods Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: March 2024

We present a genome assembly from an individual male Adalia decempunctata (the ten-spot ladybird; Arthropoda; Insecta; Coleoptera; Coccinellidae). The genome sequence is 489.4 megabases in span. Most of the assembly is scaffolded into 12 chromosomal pseudomolecules, including the X and Y sex chromosomes. The mitochondrial genome has also been assembled and is 19.68 kilobases in length.
The genome sequence of the Chalk Hill Pearl moth Mecyna flavalis (Denis & Schiffermüller, 1775)
Authors: Sims Ian , Lees David C. , Januszczak Inez ,   Natural History Museum Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: March 2024

We present a genome assembly from an individual female Mecyna flavalis (Chalk Hill Pearl moth; Arthropoda; Insecta; Lepidoptera; Crambidae). The genome sequence is 531.6 megabases in span. Most of the assembly is scaffolded into 32 chromosomal pseudomolecules, including the Z and W sex chromosomes. The mitochondrial genome has also been assembled and is 15.31 kilobases in length. Gene annotation of this assembly on Ensembl identified 12,508 protein coding genes.
The genome sequence of the Greater Wax Moth, Galleria mellonella Linnaeus, 1758
Authors: Sterling Mark J. , Barclay Maxwell V. L. , Lees David C. ,   Natural History Museum Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: March 2024

We present a genome assembly from an individual male Galleria mellonella (the Greater Wax Moth; Arthropoda; Insecta; Lepidoptera; Pyralidae). The genome sequence is 466.9 megabases in span. Most of the assembly is scaffolded into 30 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled and is 15.37 kilobases in length.
Monika Strączek ps. Halina
Authors: Rojewska Anna
Published: March 2024

"9 IV 2022 r. odeszła na wieczną wartę we Wrocławiu kpt. Monika Strączek z d. Śladewska, sanitariuszka „Halina” 27. Wołyńskiej Dywizji AK, żołnierz 2. Armii WP. [...] W kwietniu 1945 r. wzięła udział w walkach tzw. operacji łużyckiej i jej najkrwawszym epizodzie, jakim była bitwa pod Budziszynem. 6 V 1945 10. Dywizja Piechoty 2. [...] Odznaczona m.in.: Medalem za Odrę, Nysę, Bałtyk (za udział w walkach o Berlin), Srebrnym Krzyżem Zasługi, Krzyżem Kawalerskim, Orderu Odrodzenia Polski, Medalem Polonia Mater Nostra Est, Krzyżem Armii Krajowej, Złotym i Srebrnym Medalem Opiekuna Miejsc Pamięci Narodowej. Na wniosek Zarządu Dolnośląskiego ZW i RWP została awansowana do stopnia kapitana.
Danuta Szyksznian-Ossowska, ps. Sarenka
Authors: Rojewska Anna
Published: March 2024

"1 XII 2022 r. w wieku 97 lat zmarła w Szczecinie ppłk Danuta Szyksznian-Ossowska z d. Janiczak, łączniczka o pseudonimie „Sarenka”wileńskiej AK. [...] Pierwszą przysięgę konspiracyjną złożyła w Związku Wolnych Polaków – podziemnej organizacji młodzieżowej, następnie związała się ze ZWZ. Pierwsze zadania jako łączniczka wykonywała u kpt. Bolesława Zagórnego „Jana” w ZWZ, przyjmując pseudonim „Szarotka”. [...] W lipcu 1944 r. dwa miesiące po zdanej na tajnych kompletach maturze znalazła się w ogniu walk podczas operacji „Ostra Brama” (6–7 lipca). Pełniła funkcję łączniczki w dzielnicy „A” dowodzonej przez kpt. B. Zagórnego „Jana”. Zajmowała się przenoszeniem meldunków w różne części miasta. [...]"
Ta wojna zmieni wszystko... Obraz I wojny światowej w literaturze wspomnieniowej kobiet. Wybór tekstów źródłowych, opracowały Aneta Niewęgłowska, Ilona Zaleska, Wydawnictwo Naukowe Uniwersytetu Mikołaja Kopernika, Toruń 2022, ss. 446
Authors: Kromp Dorota
Published: March 2024

"Nakładem Wydawnictwa Naukowego Uniwersytetu Mikołaja Kopernika ukazało się niezwykle interesujące opracowanie źródłowe prezentujące obraz pierwszej wojny światowej w całości oparty na źródłach kobiecej literatury wspomnieniowo-pamiętnikarskiej – wspomnieniach, pamiętnikach, dziennikach i autobiografiach – w większości wydanych drukiem, ale także relacjach nieopublikowanych lub wydanych fragmentarycznie. Historiografia ostatnio coraz bardziej docenia wartość źródłową przekazów wspomnieniowych i pamiętnikarskich, także kobiecych, większą uwagę w pokazywaniu wojny zwraca się też na problematykęspołeczną, na codzienność wojenną. Książka ta pokazuje, że wojna „to nie tylko męska rzecz”, że kobiety były jej bezpośrednimi uczestniczkami. [...]"
Lidia Smentek, Spadająca co sekundę kropla wody odświeża pamięć: Batalion Śmierci za Wolność, Polskie Wydawnictwo Reklamowe, Toruń 2021, ss. 67
Authors: Mucha Piotr
Published: March 2024

"W styczniu 2020 r. przypadła 80. rocznica wywiezienia przez Niemców więźniów toruńskiego Fortu VII do obozów koncentracyjnych. Był to drugi, obok zbrodni w Barbarce z przełomu października i listopada 1939 r., akt mordu na ludności Torunia podczas zbrodni pomorskiej. Jednym z upamiętnień zamordowanych przez Niemców na początku wojny jest instalacja artystyczna Zbigniewa Mikielewicza w Parku Pamięci Ofiar Zbrodni Pomorskiej. W wyniku rozmowy z artystą Lidia Smentek podjęła się zadania opracowania niewielkiej pracy poświęconej Batalionowi Śmierci za Wolność – młodzieżowej organizacji konspiracyjnej działającej na przełomie 1939 i 1940 r. w Toruniu. [...]"
The contribution of zemstvo institutions to the formation of public education in the Podillya province
Authors: Bourdouvalis K.
Published: March 2024

The article analyses the process of formation and functioning of zemstvo institutions in Podillia from the perspective of cultural and educational space. The political and socio-economic specificity of Podillia province in particular and Right-Bank Ukraine in general largely determined the correction of the zemstvo reform in the region. Zemstvos were forbidden to interfere in the pedagogical process of schools. The state did not assign them the role of rebuilding primary education, but it turned out that as local governments, zemstvos independently expanded their powers. Thanks to the active work of these institutions, primary education became universal. The main achievement of zemstvos in the field of education in Podillia province was the opening and constant financial support of primary schools, the publication of educational literature, and the arrangement of libraries.
Information technologies, geoinformation systems and cartographic support in the system of professional training of tourism experts and geographers
Authors: Prykhodko Z. , Sych V. , Shashero A. , Molodetskiy A. , Nefedova N.
Published: March 2024

The article is devoted to the problems of using information technologies, Geographic Information Systems and cartographic materials in the tourism sector, both in the educational process and directly in the work of tourist enterprises. Emphasis is placed on specialized software products for solving the management problems of tourist enterprises. The article describes the functional features of maps, GIS products, and Internet resources used for cartographic support of tourist and recreational activities.
LEITURA DO MUNDO E IMAGINAÇÃO MATERIAL DA PALAVRA:
Authors: Bispo dos Santos Pablo Silva Machado , Carneiro Waldeck , Araujo Flávia Monteiro de Barros
Published: February 2024

O presente artigo tem por objetivo estabelecer pontos de confluência entre o pensamento de Paulo Freire e de Gaston Bachelard em torno de duas categorias centrais:“leitura do mundo” e “imaginação material da palavra”. Por meio de pesquisa bibliográfica, as ideias dos dois filósofos, notadamente o método de alfabetização de Freire e a epistemologia dialética de Bachelard, são articuladas pelas noções de “consciência”, “imaginação material” e “racionalismo”. O estudo permite concluir que as formulações de Freire, em consonância com o quadro conceitual de Bachelard, ultrapassam a mera aplicação de modelos didáticos prontos e acabados, pois enfatizam a (re)construção da visão de mundo dos educandos, a partir do estímulo à imaginação material desses sujeitos,o que potencializa sua emancipação, baseada em processos de conscientização, crítica e mudança da realidade em que estão inseridos.
LIMITES DO JULGAMENTO POR EQUIDADE NO DIREITO INTERNACIONAL
Authors: Costa Carlos Henrique Batista da , Junior Luiz Carlos Silva Faria
Published: February 2024

Este artigo tem como objetivo investigar os limites do julgamento por equidade através de uma análise exploratória das fontes do Direito Internacional Público e da jurisprudência de cortes internacionais. Para tal aborda-se inicialmente de maneira geral as fontes do DIP listadas no artigo 38 do Estatuto da Corte Internacional de Justiça, quais sejam: os costumes, os tratados e os princípios gerais de direito. Posteriormente tratar-se-á dos atos unilaterais como fontes do DIP e da equidade, para então discutir sobre a hierarquia das fontes e, finalmente, sobre o julgamento por equidade e seus limites.
Palavras-chave: Direito Internacional público; Fontes; Julgamento; equidade; conflito.
conta dos que não contam"
Authors: Massao Fairchild Thomas , Moraes Cardoso Natália
Published: February 2024

Retomamos o problema da produção de textos em sala de aula, investigando o modo como as políticas educacionais das últimas décadas podem estar favorecendo a fragmentação da posição enunciativa do aluno. Analisamos 28 redações produzidas por estudantes do Ensino Fundamental em resposta a um exercício inspirado no ENEM. Partimos de uma noção de Larrosa, para quem a política consiste na “comunicação dos desacordos”, a fim de analisar como os alunos tomam posição a respeito do tema em suas dissertações. Para tanto, lançamos mão de conceitos vinculados à Análise do Discurso (em especial, os de condições de produção, cena da enunciação, ethos e simulacro), com base nos quais analisamos algumas regularidades observáveis nos dados. Identificamos dois movimentos: de um lado, a imitação de um discurso militante tomado como modelo de enunciação presente no próprio exercício; de outro, uma série de “deslizes” por meio dos quais posições divergentes aparecem na superfície textual. Interpretamos estes últimos como ocorrências que podem resgatar o caráter político da escrita em sala de aula, na medida em que são pontos de fuga nos quais um sujeito ainda não se entregou à repetição da doxa escolar.
“The book is on the table":
Authors: Da Luz Mary Neiva surdi , KOHLER IRENE CRISTINA , CAPITANIO ALÂNA
Published: February 2024

Neste artigo analisamos quais sentidos sobre o ensino de língua inglesa circulam em memes sobre a Reforma do Ensino Médio e quais traços de uma memória funcionam nesse arquivo produzindo representações imaginárias ao ensino dessa língua. Enfatizamos a análise discursiva dos memes que abordam a inclusão obrigatória da língua inglesa no currículo do Novo Ensino Médio (NEM), de modo que selecionamos dois destes memes para compor o corpus da pesquisa que se fundamenta na perspectiva teórico-metodológica da Análise de Discurso (AD) de linha franco-brasileira. Mobilizamos conceitos de memória discursiva, memória metálica, memória digital e representações imaginárias para a análise. Lançamos linhas que tecem uma historicidade para o ensino de língua inglesa, o qual perpassou por diferentes condições de produção, das quais o digital passou a constituir outras formas de textualidades que produzem sujeitos e sentidos. Foi possível compreender que ao longo dos anos surgiram muitas propostas que colocavam em dúvida a importância das línguas estrangeiras no currículo escolar. Isso se deu devido à necessidade de professores capacitados para conduzir as abordagens e de estrutura adequada. Esse cenário ressoa e se (re)atualiza na memória que emerge das textualidades dos memes produzidos nas condições de formulação e publicação das mudanças do NEM.
O discurso da inovação no ensino: uma análise semiótica
Authors: SOUSA Silvia Maria de
Published: February 2024

A busca pela inovação está fortemente presente em diversos setores da sociedade, impondo-se como necessidade do fazer pedagógico, em todos os níveis de ensino, e também da pesquisa científica. Gamificação, sala de aula invertida e uso de plataformas digitais, entre outras, são propagadas como práticas inovadoras. Tais práticas estão previstas em documentos e diretrizes oficiais para o ensino, como a Lei que institui a Política Nacional de Educação Digital (PNED/ 2023) e  Base Nacional Comum Curricular (BNCC). Partindo dessa constatação, o trabalho tem por objetivo discutir e problematizar, com base na semiótica discursiva de linha francesa,  o tema da inovação no âmbito da educação, mais especificamente no caso do ensino de Língua Portuguesa. Acredita-se  que,  por meio do instrumental teórico consolidado da semiótica, pode-se contribuir para o debate crítico  sobre a inovação, oferecendo saídas teóricas e metodológicas erigidas da área dos estudos da linguagem.
Childcare staff bonus concerns
Authors: Virdi Amrit
Published: February 2024

Although £1,000 incentive payment is welcomed some say it won't tackle sector's retention problems
Latest figures highlight council youth services at a crossroads
Authors: Hayes Derren
Published: February 2024

YMCA analysis of trends in local authority youth services spending and provision show improvement in all measures, but experts are divided on whether it represents a short-term trend or signs of a wider recovery
Ruth Marvel
Authors: Hayes Derren
Published: February 2024

Derren Hayes speaks to the chief executive of the Duke of Edinburgh's Award scheme
Banning phones will not make children safer
Authors: Carlick Sarah
Published: February 2024

Dr Sarah Carlick is a digital safeguarding consultant
A New Blueprint for Secure Care
Authors: Andow Caroline , Stephenson Jo
Published: February 2024

A shortage of secure placements is affecting the wellbeing of some of the UK's most vulnerable children. A new research partnership is working with the sector to find out what needs to change
Improving agencies' response to tackling serious youth violence
Authors: Simpson Fiona
Published: February 2024

Review of cases in the London borough of Croydon highlights how safeguarding organisations need to work with vulnerable children as early as possible to reduce the risk of them getting involved in violent incidents
Make every contact count
Authors: Steeples Miranda
Published: March 2024

Miranda Steeples discusses the upcoming BDIA Dental Showcase.
Patient attitudes towards day-case hip and knee arthroplasty
Authors: Halken Caroline H. , Bredgaard Jensen Christian , Henkel Cecilie , Gromov Kirill , Troelsen Anders
Published: March 2024

Aims

This study aimed to investigate patients’ attitudes towards day-case hip and knee arthroplasty and to describe patient characteristics associated with different attitudes, with the purpose of providing an insight into the information requirements for patients that surgeons should address when informing patients about day-case surgery.

Methods

A total of 5,322 patients scheduled for hip or knee arthroplasty between 2016 and 2022 were included in the study. Preoperatively, patients were asked if they were interested in day-case surgery (‘Yes’, ‘Do not know’, ‘No’). Patient demographics including age, BMI, sex, and patient-reported outcome measures (PROMs) such as the EuroQol five-dimension three-level questionnaire (EQ-5D-3L) were examined within each attitude group. Additionally, changes in attitude were assessed among patients who had completed the questionnaire in association with prior hip or knee arthroplasty.

Results

Of the surveyed patients, 41.8% were interested in day-case surgery (n = 2,222), 20.8% responded ‘Do not know’ (n = 1,105), and 37.5% were not interested (n = 1,995). Patients who were not interested had a higher mean age (‘No’, 70.2 years (SD 10.0) vs ‘Yes’, 65.2 years (SD 10.7)), with a majority being female (‘No’, 71.9% female (n = 1,434) vs ‘Yes’, 48.6% female (n = 1,081)). Approximately 20% of patients responded ‘Do not know’ regardless of age, sex, and PROMs. Patients reporting anxiety/depression based on EQ-5D-3L more frequently answered ‘No’ (56.9%; 66/116) compared to those not experiencing anxiety/depression (34.9%; 1,356/3,890). Among patients who responded ‘Do not know’ before their first surgery, over 70% changed their attitude to either ‘Yes’ (29.9%; 38/127) or ‘No’ (40.9%; 52/127) at their subsequent surgery.

Conclusion

From 2016 to 2022, 58.3% of hip and knee arthroplasty patients expressed uncertainty or no interest in day-case surgery. In connection with current initiatives to increase the number of day-case arthroplasty procedures, there should be a focus on informing patients to address the prevalent negative or uncertain attitude. Further research is needed to investigate what preoperative information patients consider crucial in their decision-making process regarding day-case surgery.

Cite this article: Bone Joint J 2024;106-B(3 Supple A):3–9.
Excessive posterior pelvic tilt from preoperative supine to postoperative standing after total hip arthroplasty
Authors: Heckmann Nathanael D. , Plaskos Christopher , Wakelin Edgar A. , Pierrepont Jim W. , Baré Jonathan V. , Shimmin Andrew J.
Published: March 2024

Aims

Excessive posterior pelvic tilt (PT) may increase the risk of anterior instability after total hip arthroplasty (THA). The aim of this study was to investigate the changes in PT occurring from the preoperative supine to postoperative standing position following THA, and identify factors associated with significant changes in PT.

Methods

Supine PT was measured on preoperative CT scans and standing PT was measured on preoperative and one-year postoperative standing lateral radiographs in 933 patients who underwent primary THA. Negative values indicate posterior PT. Patients with > 13° of posterior PT from preoperative supine to postoperative standing (ΔPT ≤ -13°) radiographs, which corresponds to approximately a 10° increase in functional anteversion of the acetabular component, were compared with patients with less change (ΔPT > -13°). Logistic regression analysis was used to assess preoperative demographic and spinopelvic parameters predictive of PT changes of ≤ -13°. The area under receiver operating characteristic curve (AUC) determined the diagnostic accuracy of the predictive factors.

Results

PT changed from a mean of 3.8° (SD 6.0°)) preoperatively to -3.5° (SD 6.9°) postoperatively, a mean change of -7.4 (SD 4.5°; p < 0.001). A total of 95 patients (10.2%) had ≤ -13° change in PT from preoperative supine to postoperative standing. The strongest predictive preoperative factors of large changes in PT (≤ -13°) from preoperative supine to postoperative standing were a large posterior change in PT from supine to standing, increased supine PT, and decreased standing PT (p < 0.001). Flexed-seated PT (p = 0.006) and female sex (p = 0.045) were weaker significant predictive factors. When including all predictive factors, the accuracy of the AUC prediction was 84.9%, with 83.5% sensitivity and 71.2% specificity.

Conclusion

A total of 10% of patients had > 13° of posterior PT postoperatively compared with their supine pelvic position, resulting in an increased functional anteversion of > 10°. The strongest predictive factors of changes in postoperative PT were the preoperative supine-to-standing differences, the anterior supine PT, and the posterior standing PT. Surgeons who introduce the acetabular component with the patient supine using an anterior approach should be aware of the potentially large increase in functional anteversion occurring in these patients.

Cite this article: Bone Joint J 2024;106-B(3 Supple A):74–80.
Clinical outcomes and return to dance after total hip arthroplasty or hip resurfacing in professional dancers
Authors: LaValva Scott M. , LeBrun Drake G. , Canoles Haley G. , Ren Renee , Padgett Douglas E. , Su Edwin P.
Published: March 2024

Aims

Professional dancers represent a unique patient population in the setting of hip arthroplasty, given the high degree of hip strength and mobility required by their profession. We sought to determine the clinical outcomes and ability to return to professional dance after total hip arthroplasty (THA) or hip resurfacing arthroplasty (HRA).

Methods

Active professional dancers who underwent primary THA or HRA at a single institution with minimum one-year follow-up were included in the study. Primary outcomes included the rate of return to professional dance, three patient-reported outcome measures (PROMs) (modified Harris Hip Score (mHHS), Hip disability and Osteoarthritis Outcome Score for Joint Replacement (HOOS-JR), and Lower Extremity Activity Scale (LEAS)), and postoperative complications.

Results

A total of 49 hips in 39 patients (mean age 56 years (SD 13); 80% female (n = 39)) were included. Mean follow-up was 4.9 years (SD 5.1). Of these 49 hips, 37 THAs and 12 HRAs were performed. In all, 96% of hips returned to professional dance activities postoperatively. With regard to PROMs, there were statistically significant improvements in mHHS, HOOS-JR, and LEAS from baseline to ≥ one year postoperatively. There were complications in 7/49 hips postoperatively (14%), five of which required revision surgery (10%). There were no revisions for instability after the index procedure. Two complications (5.4%) occurred in hips that underwent THA compared with five (42%) after HRA (p = 0.007), though the difference by procedure was not significantly different when including only contemporary implant designs (p = 0.334).

Conclusion

Active professional dancers experienced significant improvements in functional outcome scores after THA or HRA, with a 96% rate of return to professional dance. However, the revision rate at short- to mid-term follow-up highlights the challenges of performing hip arthroplasty in this demanding patient population. Further investigation is required to determine the results of THA versus HRA using contemporary implant designs in these patients.

Cite this article: Bone Joint J 2024;106-B(3 Supple A):17–23.
Differences in acoustic parameters of hammering sounds between successful and unsuccessful initial cementless cup press-fit fixation in total hip arthroplasty
Authors: Homma Yasuhiro , Zhuang Xu , Watari Taiji , Hayashi Koju , Baba Tomonori , Kamath Atul , Ishijima Muneaki
Published: March 2024

Aims

It is important to analyze objectively the hammering sound in cup press-fit technique in total hip arthroplasty (THA) in order to better understand the change of the sound during impaction. We hypothesized that a specific characteristic would present in a hammering sound with successful fixation. We designed the study to quantitatively investigate the acoustic characteristics during cementless cup impaction in THA.

Methods

In 52 THAs performed between November 2018 and April 2022, the acoustic parameters of the hammering sound of 224 impacts of successful press-fit fixation, and 55 impacts of unsuccessful press-fit fixation, were analyzed. The successful fixation was defined if the following two criteria were met: 1) intraoperatively, the stability of the cup was retained after manual application of the torque test; and 2) at one month postoperatively, the cup showed no translation on radiograph. Each hammering sound was converted to sound pressures in 24 frequency bands by fast Fourier transform analysis. Basic patient characteristics were assessed as potential contributors to the hammering sound.

Results

The median sound pressure (SP) of successful fixation at 0.5 to 1.0 kHz was higher than that of unsuccessful fixation (0.0694 (interquartile range (IQR) 0.04721 to 0.09576) vs 0.05425 (IQR 0.03047 to 0.06803), p < 0.001). The median SP of successful fixation at 3.5 to 4.0 kHz and 4.0 to 4.5 kHz was lower than that of unsuccessful fixation (0.0812 (IQR 0.05631 to 0.01161) vs 0.1233 (IQR 0.0730 to 0.1449), p < 0.001; and 0.0891 (IQR 0.0526 to 0.0891) vs 0.0885 (IQR 0.0716 to 0.1048); p < 0.001, respectively). There was a statistically significant positive relationship between body weight and SP at 0.5 to 1.0 kHz (p < 0.001). Multivariate analyses indicated that the SP at 0.5 to 1.0 kHz and 3.5 to 4.0 kHz was independently associated with the successful fixation.

Conclusion

The frequency bands of 0.5 to 1.0 and 3.5 to 4.0 kHz were the key to distinguish the sound characteristics between successful and unsuccessful press-fit cup fixation.

Cite this article: Bone Jt Open 2024;5(3):154–161.
¿Los consejos fiscales inciden sobre la gestión de las finanzas públicas nacionales? Un estudio cuasiexperimental con datos de panel
Authors: Marcano Jesús , Sánchez Karla , Puente José Manuel
Published: March 2024

The public deficit and debt levels of western countries have increased significantly in the last 30 years. In response to this, the implementation of fiscal councils has been gaining popularity as a measure to contain the deficit bias. These institutions seek to discourage a deficitarian managment of resources by providing information on the status of public finances, in order to increase citizen scrutiny and motivate a responsible government administration. This paper seeks to evaluate the effectiveness of these institutions by following an identification strategy based on synthetic control and difference-in-differences techniques. Although some of the resulting estimates indicate the existence of favorable impacts on the primary balance, most estimates show that the fiscal councils do not significantly influence fiscal management. Therefore, no conclusive evidence was found on the effectiveness of these institutions.
Aplikasi Metode Market Basket Analysis dengan Algoritma Apriori untuk Mengetahui Pola Belanja Konsumen pada Online Shop Amerta Fashion
Authors: Utami Iut Tri , Dapa Rahmila
Published: February 2024

In this era of globalization, society has been facilitated in various ways due to advances in technology, one of which is the use of the internet. One of the goals of the continuous development of technology is to meet human needs. According to a global survey conducted by Nielsen Online in 2009, more than 85% of the world's population has used the internet for buying and selling transactions. The increase in purchases made online, especially during this pandemic period, shows that people have begun to be technology literate. The large number and rapid growth of data often overwhelm business actors in processing data so that they are left unorganized, even though the data obtained can produce useful information to support decisions or assist in determining marketing strategies. This difficulty also occur at Online Shop Amerta Fashion. This study uses one of the data mining methods, namely Market Basket Analysis with a priori algorithm which goes through the stages of data collection, formation of association rules, and concluding. Market basket analysis can determine consumer buying patterns and also find out which items are selling well. The results obtained is that consumers of Online Shop Amerta Fashion didn’t only buy 1 item in a transaction. Boyfriend Jeans Highwaist and Wrap Top Summer are 2 types of items that are popularly purchased by consumers so that they become the most influential items in the overall purchasing transactions from Online Shop Amerta Fashion from January 4, 2021 to June 18, 2021.

Keywords: data mining; association rules; market basket analysis; Apriori; Online Shop Amerta Fashion
FEMALE ENTREPRENEURSHIP: SKILLS FRAMEWORK FOR BRAZIL
Authors: De Azevedo Amanda Trevisan , Liboni Lara Bartocci , Cezarino Luciana Oranges , De Araujo Geraldo Jose Ferraresi , Martins Flavio Pinheiro
Published: February 2024

Female entrepreneurship plays a central role in economic and social development; as a research topic, it has attracted attention from several areas. Work and research on female entrepreneurship are predominantly oriented from the perspective of the roles socially attributed to women. This research is based on Organizational Theory and aims to analyze entrepreneurship-related competencies, developing an integrative framework between macro-skills from scientific literature and the Global Entrepreneurship Monitor (GEM). Through a systematic review of the literature and applying a questionnaire, in which the data was subjected to cluster analysis using the agglomerative method, it was possible to develop a new proposal for grouping female entrepreneurial skills. The results contribute to the literature on female entrepreneurship and to discussions of gender and equality in organizations, stimulating new policies and strategies for the development of female entrepreneurship.
Disparities in oral health according to the socioeconomic status of adults: analysis of data from the 7th Korea National Health and Nutrition Examination Survey
Authors: Jung Eun-Ju
Published: February 2024

Objectives: This study aimed to analyze the relationship between the socioeconomic status and oral health of adults. Methods: Data from the 7th Korea National Health and Nutrition Examination Survey (2016–2018) were analyzed, and 13,199 adults aged 19 years or older were selected as study subjects. Various oral health indicators were used to analyze the effect of socioeconomic status on oral health. Disparities in oral health according to socioeconomic status were analyzed using the complex sample chisquared test and multiple logistic regression analysis. Results: A statistically significant difference was observed between income level, medical aid, and all oral health indicators, which indicated that the lower the income level, the lower the oral health level (p<0.001). Furthermore, all oral health indicators displayed statistically significant differences, with the exception of the prevalence of dental caries and education level. The lower the education level, the lower the oral health level (p<0.001). Therefore, the oral health level of adults presented significant differences according to different socioeconomic status indicators. Conclusions: To prevent oral health inequalities, the government and local governments need to intervene not only in the field of health care but also in the social determinants. Additionally, concerted efforts should be made to eliminate oral health disparities by improving policies and systems.
Awareness and needs for integrated care convergence education among some health students
Authors: Cho Hye-Eun , Lee Ji-Yeon , Han Jong-Hee
Published: February 2024

Objectives: This was carried out to develop an integrated care convergence curriculum. Methods: An online survey was conducted on 312 public health college students, and frequency analysis, t-test, ANOVA, and chi-square test were conducted. Results: Awareness of convergence education (2.55) and experience of convergence education (10.26%) were low, but those with education experience had high awareness of integrated care and convergence education (p<0.001). The need for education (3.07) and manpower training (3.14) were both high, and the preferred training content was first aid (3.57). Conclusions: Additional research is needed on the development of integrated care convergence curriculum.
“I dreamt that the world was on fire”: Boston King’s Memoirs , Visionary Discourse, and Colonial Salvation
Authors: Lockard Joe
Published: February 2024

Abstract: Memoirs of Boston King, a Black Preacher appeared in serial form in The Methodist Magazine between March and June 1798. King escaped slavery in South Carolina, joined the British army to fight in the Revolutionary War, eventually resettled in Nova Scotia, and emigrated to Sierra Leone. This essay argues that readings of King’s Memoirs solely as a historical document are inadequate. The essay first summarizes King’s biography and contextualizes it within early Methodist history; a second section reads epiphanic visionary moments in King’s narrative; and a third section considers how colonial and white supremacist thought in the early Methodist church employed King’s narrative as a conversionary instrument.
Enslavement, Freedom, and Marronage in N. K. Jemisin’s Broken Earth Trilogy
Authors: Anderson Lisa M.
Published: February 2024

Abstract: This essay argues that N. K. Jemisin’s award-winning Broken Earth science fiction trilogy engages the concepts of freedom, enslavement, and marronage through the stories of her orogene narrators Essun and Nessun. Through the complexity of the trilogy, Jemisin challenges her readers to consider the nature of enslavement and freedom, and the challenges and necessity of radical transformation to create new ways of being.