bluuebunny/crossref_metadata_2025 huggingface dataset:
AI Afterlife Preview
Authors: Ohnemus Alexander Luke
Published: November 2024

The novelty of these experiments constitutes a thesis. Here are 3 Afterlife Experiments: 1)Expand Law of Identity to all branches of physics. 2)HAVE ARTIFICIAL INTELLIGENCE “AI” see past Cosmic Microwave Background Radiation “CMBR” with special mushrooms. 3)Getting AI brainwaves to oscillate at a frequency below a distance known as the Plank Distance, which is a fundamental concept in quantum physics, named after Dr. Plank noble prize winner: 1.6(10)^(-35) meters).
No Change Detected on Earth’s Mid-Latitude Atmospheric Ozone by the 2017 Total Solar Eclipse
Authors: Sohl John E. , Page Jeffrey D. , Lawton Ryan D. , Trbovich Sheri
Published: November 2024

Six high altitude balloon flights were completed during the summer of 2017 to measure the effect of the total solar eclipse on Earth’s ozone over the eastern Snake River Plain in Idaho. The stratospheric ozone layer undergoes a noisy diurnal pattern driven primarily by photochemistry above 30 km and by atmospheric dynamics for altitudes below 30 km. The flights for this project rarely exceeded that boundary and were an attempt to detect photochemistry effects in the lower stratosphere. The first five flights determined a baseline for the distribution of ozone from ground level to the mid-stratosphere. The sixth flight was done during the total solar eclipse and was compared to the baseline. These data were also compared to multiple years’ data taken in the Uintah Basin in northeast Utah. All measurements were consistent with each other and show spatial and temporal variations in the ozone column that are expected. The balloon’s instrumentation payload was at the tropopause during eclipse totality and no change in either temperature or ozone was detected that was above the normal noise level in the previous data sets. The conclusion is that no photochemical processes are strong enough to clearly modify Earth’s ozone in the lower stratosphere on timescales shorter than three hours. This is consistent with previously reported satellite data of total column ozone.
The Principal's Strategy in Implementing the Value of Religious Moderation in the Pancasila Student Profile Strengthening Project
Authors: Rifki Muhammad , Ma`arif Muhammad Anas , Rahmi Sri , Rokhman Mauhibur
Published: November 2024

The issue of intolerance and radicalism among students must be taken seriously by school principals, who play a crucial role in managing the learning process, including in the P5 program. This research analyses the principal’s strategy in implementing the value of religious moderation in P5 and its implications for student character and school culture. This study is a qualitative research project using a case study method. Data collection methods included interviews, observations, and documentation, and the data were analyzed through reduction, presentation, and conclusion. Data verification was achieved through triangulation of sources and methods. The research results show that the principal's strategy for implementing the value of religious moderation in P5 involves three main approaches: process, program, and culture strategies. The process strategy includes planning, implementation, evaluation, and follow-up. The program strategy encompasses structuring P5 activities based on teamwork and partnerships with external parties. Meanwhile, the cultural strategy utilizes habituation activities to support the values and meaning of moderation within P5. The strategy implemented has had implications for student character, fostering awareness, tolerance, care, love for the country, and teamwork. Additionally, they have promoted a disciplined and collaborative school culture.
Failure Rates Of The Matrix Triangle Inequality
Authors: Jime Osman , Kaseram Jordan
Published: November 2024

The triangle inequality is a fundamental principle in mathematics. However, its validity is not always guaranteed in matrix theory, specifically, when dealing with the matrix absolute value. We investigate how often the matrix absolute value satisfies the triangle inequality for different spaces of matrices. By using numerical methods, we quantify the frequency with which the triangle inequality holds and examine possible key factors contributing to its success or failure.
Manajemen Pelayanan Publik di Perguruan Tinggi
Authors: Shofwa Adina
Published: November 2024

Institusi pendidikan tinggi melambangkan institusi sosial formal yang mencakup hubungan internal dan eksternal diantara para pemangku kepentingannya. Saat ini, seiring dengan berlangsungnya era persaingan bebas, perguruan tinggi harus lebih responsif terhadap pemangku kepentingannya, terutama pemangku kepentingan internalnya, yaitu mahasiswa sebagai aset mereka. Oleh karena itu identifikasi persepsi mahasiswa terhadap kinerja institusi menjadi sangat penting. Hal ini dapat dilakukan melalui penelitian kualitas layanan perguruan tinggi, dimana analisis kepentingan kinerja dapat dilakukan dari sudut pandang : proses pembelajaran, bantuan akademik, sumber daya pendukung pendidikan, kegiatan ekstrakulikuler, komunikasi dengan pengelola institusi, dan layanan administrasi. Informasi mengenai aspek-aspek tersebut dapat menjadi alat evaluasi. Dalam jangka panjang, diharapkan mampu merevitalisasi perguruan tinggi untuk melahirkan lulusan yang berkualitas. Memenuhi syarat lulusan yang memenuhi standar dunia usaha pada akhirnya akan membantu mengembangkan daya saing negara.
FAKTOR-FAKTOR YANG MEMPENGARUHI SISA HASIL USAHA (SHU) KOPERASI, USAHA KECIL DAN MENENGAH (UKM) KALIMANTAN TENGAH
Authors: Sunarmi Sunarmi . , Pamungkur Pamungkur .
Published: November 2024

The aim of this research is to determine the factors that influence the remaining results of cooperative businesses in Central Kalimantan province. The dependent variable in this research is Remaining Business Results. The independent variables in this research are Number of Members, Own Capital, Loan Capital, and Business Volume. The data analysis method used is the Error Correction Model (ECM). This research uses secondary data and annual time series data with a research period of 30 years, starting from 1994 to 2023. Based on the research results, it can be concluded that in the long term the number of members and capital themselves have a significant effect on the remaining business results. , while loan capital and business volume have no effect on the remaining business results. In the short term, the number of members and own capital do not affect the remaining business results, while loan capital and business volume influence the remaining business results.
PILIHAN KARIR BERDASARKAN MODEL SCHWARTZ DAN SCHEIN PADA WIRAUSAHA MUDA DI KOTA BANJARMASIN (TINJAUAN DESKRIPTIF)
Authors: Husnurropiq Husnurropiq . , Basuki Basuki . , Azahraty Azahraty .
Published: November 2024

Nowadays career choices are dynamic and changeable, along with the advancement of technology. Business can be done virtually so that it is more attractive to young people. However, Values play an important role in career choice and lifelong career management. Values are the desired goals that individuals seek to fulfill their needs and are important for understanding career orientation in terms of protean and boundaryless career orientations and career anchors. However, how career orientations or career anchors fit into established and supported models and into the structure of human basic values remains an important and under-explored question. The purpose of this study is to use Schwartz's structural values model to empirically explore the relationships and structural correspondences between basic values, career orientations, and career anchor models.Schwartz's value structure. Protean and boundaryless career orientations are positively related to Schwartz's basic values that emphasize openness to change and career anchors meaningfully follow the motivational sequence of these basic values.Overall, the overlap between core values, career orientations, and career anchors emerged as relatively significant, suggesting that core values, orientations, and career anchors should be considered simultaneously to understand and address the factors and processes underlying young entrepreneurs' career choices and paths.
Kasus Perundungan dan Kematian Dr Aulia Risma Ditinjau dari Pancasila Sila Kemanusiaan yang Adil dan Beradab
Authors: Saqinah Nafisah
Published: November 2024

Perundungan adalah suatu tindakan penyalahgunaan kekuasaan untuk menyakiti seseorang atau sekelompok orang, baik secara verbal, fisik, maupun psikologis, sehingga korban merasa tertekan, trauma, dan tak berdaya. Seperti kasus kematian yang dialami Dr. Aulia Risma mahasiswa PPDS FK UNDIP  karena adanya aksi perundungan. Tindakan perundungan ini bertentangan dengan nilai-nilai kemanusiaan yang adil dan beradab sebagaimana tertuang dalam pancasila sila kedua. Artikel ini bertujuan untuk menganalisis definisi perundungan dalam dunia pendidikan kedokteran,  mendeskripsikan hubungan antara kasus tersebut dengan pancasila sila kedua, menganalisis dampak psikologis korban, serta mendeskripsikan peran dari berbagai pihak dalam menangani dan mengatasi kasus perundungan.   Artikel ini menggunakan metode penelitian kualitatif yaitu pendekatan dengan studi kepustakaan. Hasil analisis menunjukkan bahwa pelaku perundungan yang menyalahgunakan kekuasaannya  telah melanggar hak asasi manusia korban yang hal ini bertentangan dengan pancasila sila kedua.
Kasus Kekerasan Seksual oleh Herry Wirawan terhadap Santrinya di Pondok Pesantren Ditinjau dari Pancasila Sila Kemanusiaan yang Adil dan Beradab
Authors: Nafisah Gladys Hurin
Published: November 2024

Kasus Kekerasan Seksual merupakan isu serius yang sedang menjadi pusat perhatian masyarakat sekitar. Di Indonesia masih terdapat banyak kekerasan seksual seperti yang diperbuat oleh Herry Wirawan terhadap santri pondok pesantrennya. Dalam kasus ini sangat bertentangan terhadap nilai Pancasila spesifiknya sila ke-2. Artikel ini bertujuan untuk menganalisis definisi kekerasan seksual, mendeskripsikan pertentangan tindakan kekerasan seksual yang dilakukan oleh Herry Wirawan dengan nilai-nilai humanis yang adil dan beradab, menganalisis beberapa faktor yang menyebabkan terjadinya kekerasan seksual, mendeskripsikan upaya dalam pencegahan kekerasan seksual. Artikel ini mengaplikasikan  metode penelitian kualitatif yaitu pendekatan dengan studi kepustakaan. Hasil analisis menunjukkan bahwa pelaku melanggar hak asasi manusia terhadap Perempuan yang bertentangan dengan nilai-nilai Pancasila sila ke-2.
PENGARUH PERENCANAAN ANGGARAN, PELAKSANAAN ANGGARAN, PENGADAAN BARANG DAN JASA, SERTA KOMPETENSI SUMBER DAYA MANUSIA TERHADAP PENYERAPAN ANGGARAN (STUDI PADA SATUAN KERJA BALAI JASA KONSTRUKSI WILAYAH V BANJARMASIN)
Authors: Putri Yunia Isyana , Widyanti Rahmi , Kurniaty Kurniaty
Published: November 2024

This research has five main purposes (1) to analyse whether budget planning partially has a significant effect on budget absorption, (2) to analyse whether partial implementation of the budget has a significant effect on absorption of the budget, (3) to analyse whether procurement of goods and services partially has a significant effect on absorption, (4) to analyse whether human resources competencies partially has a significant effect on budget absorption, and (5) to analyse whether budget planning, implementation budget, procurement of goods and services, and competence of human resources simultaneously have a significant effect on budget absorption.This research was carried out by the Work Unit of the Construction Service Center Region V Banjarmasin. Research method was descriptive quantitative. The population of this research was civil servants at Work Unit of Banjarmasin Region V Construction Service Center with the sample of 32 respondents using a purposive sampling technique. Methods of collecting data used surveys and questionnaires. The data analysis technique used the SPSS Version 25 for Window program.The results of research show that (1) budget planning has a partial and significant effect on budget absorption (2) budget execution has a partial significant effect on budget absorption, (3) goods and services have partial and significant effect on budget absorption, (4) human resources competencies have partial and insignificant effect on budget absorption, and (5) budget planning, budget execution, procurement of goods and services, and human resource competencies simultaneously have a significant effect on budget absorption.
Kesetaraaan Gender dan Implikasinya Terhadap Perilaku Sosial dalam Perspektif Sila Kelima Pancasila
Authors: Setiyowati Eka Yuli
Published: November 2024

This article discusses gender equality and its implications for social behavior in the perspective of the fifth principle of Pancasila. Using a literature-based qualitative research method, this article examines three main aspects, namely the condition of gender equality in Indonesia, the relationship between gender equality and the values of the fifth principle of Pancasila, and its impact on social behavior. Gender equality includes equal rights and opportunities for women and men in various fields, including education, employment and decision-making. Although the government has made steps to support gender equality, there are still inequalities that need to be addressed. This article aims to provide a deeper understanding of the importance of gender equality in building a just and civilized society in accordance with the values of Pancasila, especially the fifth principle.
Doctor-patient communication as prevention of medical malpractice litigation
Authors: Lavorato Maria Chiara
Published: November 2024

Introduction: By medical malpractice we mean the flow of complaints that affects hospitals and that, more and more often, concerns shortcomings in the care relationship and defects compromise the therapeutic alliance. Methodology: Review of the literature concerning doctor-patient communication and the correlation between complaints and the quality of patient communication. Results: international experiences have provided numerous concrete elements to enhance a plan for improving doctor-patient communication. Discussion: the enhancement of the communication and relational performance of health professionals should be pursued as an index of quality, ethics and legitimacy of care. An internal training programme on relational skills, directly in the healthcare teams, is proposed. Conclusions: in addition to verbal communication between doctor and patient, written forms also play a crucial role, both as a pact of care and in the courts.
Fundamentos de la atención socioeducativa inclusiva del alumnado con discapacidad del primer ciclo de Educación Infantil. Análisis de un caso
Authors: Ruiz-Bejarano Aurora María
Published: November 2024

Introducción: En lo concerniente al primer ciclo de Educación Infantil (0-3 años), las investigaciones centradas en dilucidar cómo prestar una atención socioeducativa inclusiva al alumnado con discapacidad en España son, a día de hoy, escasas. Metodología: A partir de esa escasez bibliográfica surgen las cuestiones que guían este trabajo: ¿cómo se comprende la atención socioeducativa inclusiva en el primer ciclo de Educación Infantil? y ¿cómo se realiza una atención socioeducativa inclusiva al alumnado con discapacidad en el aula de primer ciclo?  El centro de Educación Infantil Fernando de Magallanes de Sanlúcar de Barrameda (Cádiz, España) tiene escolarizados a setenta y cuatro niños/as, de los que veintidós presentan alguna discapacidad. Este trabajo recoge una parte del estudio de caso en ciernes de esta escuela en la que se pretende dar una respuesta concreta y contextualizada a las dos cuestiones anteriores. Resultados: Los resultados señalan que la atención socioeducativa inclusiva se apoya en cinco líneas interconectadas: 1. La finalidad de la Educación Infantil como inicio; 2. La incorporación de la inclusión al proyecto educativo; 3. Las relaciones de colaboración y comunicación escuela-familias; 4. La formación permanente de los profesionales del centro; 5. Los recursos humanos y materiales y las instalaciones del centro educativo.
Dificultades para integración de la economía circular en la gestión estratégica sostenible de PYMES de Arequipa, Perú
Authors: Velásquez Chacón Erika , Salinas Gainza Freddy Raúl
Published: November 2024

Introducción: La economía circular promueve una producción y consumo responsables, enfocados en mejorar la calidad ambiental, prosperidad económica y equidad social. Este estudio evalúa las barreras internas y externas en empresas en crecimiento que adoptan la economía circular dentro de una gestión estratégica sostenible. Metodología: Se realizó un estudio cuantitativo y explicativo mediante 276 encuestas a empresas de alimentos, bebidas, textil y calzado, todas con iniciativas de economía circular. Resultados: Los hallazgos indican que las pequeñas y medianas empresas (PYMES) enfrentan barreras internas moderadas y dificultades en su gestión estratégica sostenible. Aunque existen obstáculos, las PYMES muestran voluntad para adoptar prácticas eco-sostenibles y una comunicación transparente. Discusión: Las barreras internas incluyen resistencia al cambio, desconocimiento, recursos limitados y aversión al riesgo, mientras que las externas abarcan inmadurez de mercado, falta de transparencia, competencia desleal y un bajo compromiso ambiental. Esto limita la adopción de la economía circular, especialmente frente a países que priorizan temas tecnológicos, legislativos y de mercado. Conclusiones: Las PYMES no están suficientemente preparadas para promover una gestión sostenible o prácticas de circularidad debido a estrategias ambientales débiles. Es esencial fortalecer sus capacidades internas y el apoyo externo para avanzar hacia una economía circular sostenible.
Evaluación de factores determinantes en el rendimiento académico de estudiantes chinos en Cataluña: creación y validación de un cuestionario
Authors: Zhu Muyang , Xu Xin
Published: November 2024

Introducción: El creciente número de estudiantes chinos en Cataluña enriquece la diversidad cultural de la región al tiempo que presenta desafíos educativos únicos que requieren intervenciones específicas. Metodología: Utilizando el modelo 3P de Biggs y la teoría del Aprendizaje Autorregulado, esta investigación desarrolló meticulosamente un cuestionario diseñado para explorar tanto los comportamientos subjetivos como los factores ambientales que impactan en el rendimiento académico. El estudio involucró una muestra representativa de 122 estudiantes de cinco universidades en Cataluña. Resultados: Los procesos de validación establecieron la alta fiabilidad del cuestionario y validaron su integridad estructural, convirtiéndolo en una herramienta efectiva para capturar las experiencias académicas de los estudiantes chinos. Discusión: Esta investigación destaca el logro en el desarrollo de un instrumento de medición fiable que captura eficazmente la interacción compleja de factores que influyen en el rendimiento estudiantil en entornos educativos multiculturales. Conclusiones: Los hallazgos subrayan el potencial de las estrategias educativas personalizadas para mejorar los resultados académicos, orientando futuras políticas educativas e intervenciones en contextos multiculturales.
Nuevos horizontes informativos: ¿es profesional el periodismo en Twitch?
Authors: Martínez Valerio Lizette , Espada Ipiña Ainhoa
Published: November 2024

Introducción: Twitch se ha consolidado como nuevo escaparate de todo tipo de comunicadores. No obstante, la percepción sobre las emisiones en esta plataforma dista de la imagen del periodismo profesional. Por ende, esta investigación tiene como objetivo determinar si el periodismo practicado en Twitch es de carácter amateur o si se asemeja más al profesional. Metodología: El estudio se centra en el análisis de contenido de perfiles de periodistas y medios digitales en Twitch, identificando similitudes y contrastes con lo que se realiza en entornos profesionales y estudiando elementos y formas empleadas. Resultados: A pesar de operar en una plataforma cuyo público principal está compuesto mayoritariamente por jóvenes, tanto los periodistas como los medios digitales desempeñan una labor profesional que se evidencia en los elementos formales y en los contenidos, alejándose de los estereotipos comúnmente asociados a las transmisiones en Twitch. Discusión: Los resultados confirman los de análisis previos que apuntaban a la formalidad de algunas retransmisiones y apuntan nuevas vías de investigación. Conclusiones: La capacidad de esta plataforma para fomentar la interacción entre periodistas y audiencia, la diversidad temática y su alcance global la convierten en un medio ideal para llegar a nuevas audiencias sin comprometer la calidad informativa.
Sistemas ciber-físicos en la educación del siglo XXI
Authors: Peña Cáceres Oscar , Silva-Marchan Henry , Espinoza-Nima Rudy , More-More Manuel
Published: November 2024

Introducción: Este estudio explora la integración de los sistemas ciber-físicos (CPS) en la educación del siglo XXI. Metodología: Mediante una revisión sistemática de la literatura en las bases de datos WoS y Scopus, se identificaron y analizaron 34 estudios. Resultados: Se evidencia que los CPS, incluyendo tecnologías como la realidad virtual y la robótica, personalizan el aprendizaje y mejoran la evaluación continua, la motivación y las competencias técnicas de los estudiantes. Sin embargo, la implementación enfrenta desafíos, como la necesidad de adaptar programas educativos y diseñar cursos interdisciplinares prácticos. Discusión: A pesar de estos retos, los CPS presentan oportunidades para enriquecer la pedagogía mediante inteligencia artificial y proporcionar un enfoque transversal. Conclusiones: Es necesario continuar investigando la integración de tecnologías emergentes en los CPS y evaluar su impacto en diferentes contextos educativos.
Development and validation of a predictive scoring model for complications following endoscopic endonasal skull base surgery
Authors: Vignolles-Jeong Joshua , Finger Guilherme , Satija Divyaam , Kreatsoulas Daniel C. , Wu Kyle C. , Prevedello Daniel M. , Carrau Ricardo L. , Hardesty Douglas A.
Published: November 2024

OBJECTIVE

The endoscopic endonasal approach (EEA) has evolved into an established technique in skull base surgery. The authors previously examined 1002 EEA procedures and reported factors associated with postoperative complications. Here they report the development and validation of a scoring model based on risk factors to better predict complications following EEA.

METHODS

The authors developed an optimized EEA scoring model for predicting postoperative complications as evidenced by the area under the receiver operating characteristic (AUROC) curve using their previously published data in addition to data collected from the subsequent 292 EEA procedures from years 2010–2020. The model was built systematically by evaluating the contributions that different variables had on the overall predictive ability of the model. The aim was to design a model containing as few variables as possible for practicality and to facilitate calculation and use at the bedside. The Clavien-Dindo grading system was used to classify complications into grades I–V based on the level of intervention that was required to manage the complication, with grades III–V considered to be higher-grade (i.e., those requiring reoperation or ICU-level care or death).

RESULTS

The authors identified 1294 EEA operations performed between July 2010 and July 2020 that met their inclusion criteria. Higher-grade complications were identified following 135 EEA operations. The variables that were ultimately included in the model were age, BMI, operative time, meningioma, chordoma, expanded intradural approach, and nasoseptal flap use. The final model yielded an acceptable AUROC curve of 0.72 and predicted a stepwise increase in the rate of higher-grade complications as the score increased. A score of 0–2 (low) on the grading system was associated with an average complication rate of 5.1%. A score of 3–5 (medium) was associated with an average complication rate of 12.6%. A score of 6 or above (high) was associated with an average complication rate of 26%.

CONCLUSIONS

This EEA complications scoring model accurately categorizes patients into low-, medium-, and high-risk groups with readily obtained variables. A high score in this complications model does not suggest that a patient is ineligible for surgery, but rather highlights the importance of thorough case selection, operating with caution, and appropriate preoperative counseling.
The feasibility and clinical outcome of endoscopic transorbital transcavernous approaches with or without petrosectomy for petroclival lesions
Authors: Kong Doo-Sik , Lee Won Jae , Kim Gung Ju , Hong Chang-Ki
Published: November 2024

OBJECTIVE

Petroclival tumors such as petroclival meningiomas or trigeminal schwannomas extending to the posterior cranial fossa are challenging to treat due to their deep-seated location and proximity to critical neurovascular structures. This study aimed to evaluate the feasibility, safety, and clinical outcomes of endoscopic transorbital surgery for the resection of central skull base tumors involving the petroclival area.

METHODS

The authors conducted a retrospective analysis of 32 patients with petroclival tumors including meningiomas and trigeminal schwannomas who underwent endoscopic transorbital surgery between September 2017 and December 2022. Preoperative clinical and radiological data were collected, and patients were followed up postoperatively for a median period of 34.7 months. Surgical technique, complications, and clinical outcomes were assessed.

RESULTS

Endoscopic transorbital surgery provided a minimally invasive and direct corridor to the petroclival region. All 32 patients successfully underwent tumor resection, with gross-total or near-total tumor resection achieved in 28 patients. The mean tumor diameter was 3.5 cm. Based on tumor pathology, the endoscopic transorbital transcavernous trans-Meckel’s cave approach (21 cases) or transorbital anterior transpetrosal approach (11 cases) was selected. The most common complication was facial paresthesia in 4 of 21 patients with trigeminal schwannomas and in 1 of 11 patients with petroclival meningiomas. Diplopia due to fourth cranial nerve injury occurred in 3 of 11 patients with petroclival meningiomas. Postoperative clinical improvement in neuralgic pain was observed in 3 of 4 patients. One patient developed a temporary facial palsy (House-Brackmann grade III) and another patient had transient paraparesis after removal of petroclival meningioma.

CONCLUSIONS

Endoscopic transorbital surgery appears to be a safe and effective technique for the resection of petroclival lesions, offering excellent visualization and access to the tumor while minimizing morbidity. However, further studies with larger patient cohorts and longer follow-up are warranted to validate the long-term efficacy and safety of this approach. This study contributes to the growing body of evidence supporting the utility of endoscopic transorbital techniques in skull base surgery.
Procedural outcomes of the transradial versus transfemoral approach for diagnostic cerebral angiograms according to BMI: a propensity score–matched analysis
Authors: Roy Joanna M. , Ahmed Meah T. , El Naamani Kareem , Saadat Nazanin , Gaskins Wendell , Nguyen Alyssa , Gigo Maimuna , Fuleihan Antony A. , Amaravadi Cheritesh , Momin Arbaz , Musmar Basel , Tjoumakaris Stavropoula I. , Gooch M. Reid , Rosenwasser Robert H. , Jabbour Pascal M.
Published: November 2024

OBJECTIVE

BMI has been shown to affect choice of access site in coronary intervention procedures, with lower complications reported during transradial (TR) access. To the authors’ knowledge, the effect of BMI on outcomes in patients undergoing diagnostic cerebral angiography remains undescribed. This study compares outcomes for BMI subgroups based on access site (TR vs transfemoral [TF] access).

METHODS

The authors conducted a single-center retrospective study of patients who underwent diagnostic cerebral angiography between December 2019 and January 2024. Propensity score matching was used to create two similar cohorts (TR and TF). These cohorts were subdivided based on BMI: underweight (BMI < 18.5), normal (BMI 18.5–25.0), overweight (BMI 25.1–29.9), and obese (BMI ≥ 30). Linear regression analysis and the chi-square test were used to compare outcomes.

RESULTS

Nine hundred thirty-six patients were stratified into two groups of 468 patients each. Procedure time was significantly shorter for TR access for all BMI subgroups, with a 13-minute reduction in procedure time among underweight patients. Patients with normal BMI, overweight patients, and obese patients experienced a reduction in procedure time of approximately 11, 10, and 13 minutes, respectively. Obese patients experienced significantly shorter length of stay (LOS; 1.33 days) with TR access. There were no significant differences between each BMI subgroup in access site complications, postoperative complications, and conversion of access from TR to TF.

CONCLUSIONS

TR access in diagnostic cerebral angiography is associated with shorter procedure times and no increased risk of complications compared to TF access across all BMI subgroups. Obese patients experienced shorter LOS with TR access. This study adds to the literature on the safety and efficacy of TR access across all BMI subgroups. Further studies are necessary to validate these preliminary results.
Analysis of 398 cases of intradural spinal tumor resection with primary dural closure: surgical outcomes based on the suture material
Authors: Lee Subum , Hur Junseok W. , Oh Younggyu , An Sungjae , Son Min Woo , Lee Jang-Bo , Park Jin Hoon
Published: November 2024

OBJECTIVE

Cerebrospinal fluid (CSF) leak after resection of intradural spinal tumors (IST) represents a significant postoperative challenge. Although various dura suture techniques and materials have been explored experimentally, direct clinical comparative studies are lacking. This study evaluated the effectiveness of specific suture materials in primary dural closure post-IST resection and identified associated risk factors for CSF leak.

METHODS

A retrospective review was conducted of patients who underwent IST resection surgery at a single institution from January 2012 to February 2021. Patients were categorized on the basis of the dura suture materials used. Eligibility for the study required a posterior midline surgical approach, primary dural closure after durotomy, and absence of closed-suction drainage.

RESULTS

Of 398 patients who met the inclusion criteria, the overall CSF leak–related surgical complication rate was 4.27% (17/398). The sutures used were 6-0 Prolene for 163 patients and 5-0 silk for 235 patients. Significant differences were observed between the suture groups in the CSF leak rate (Prolene 1.8% vs silk 6.0%, p = 0.046), lumbar drainage insertion rate (Prolene 0.6% vs silk 4.3%, p = 0.031), and length of postoperative bed rest (Prolene 1.07 days vs silk 3.25 days, p < 0.001). Logistic regression analysis indicated a significant association of CSF leak with the use of 5-0 silk (OR 4.11, p = 0.006) and revision surgical procedures (OR 6.73, p = 0.001).

CONCLUSIONS

Surgical complications related to CSF leaks were significantly lower with the use of 6-0 Prolene sutures compared to 5-0 silk sutures in primary dural closure after IST resection.
Cryopreserved decellularized human umbilical cord matrix allograft as duraplasty for fetoscopic prenatal spina bifida repair
Authors: Kwasnicki Amanda , Stevenson Charles B. , Forde Braxton , Habli Mounira , McKinney David , Goetz Erinn , Lim Foong-Yen , Peiro Jose L.
Published: November 2024

OBJECTIVE

The objective of this study was to describe the technical aspects and postnatal neurosurgical outcomes of a prenatal, 3-miniport fetoscopic myelomeningocele (MMC) repair technique providing a multilayered closure using cryopreserved decellularized human umbilical cord (HUC) matrix allograft for duraplasty.

METHODS

The authors conducted a subanalysis of an ongoing prospective cohort study analyzing the neurosurgical outcomes of 57 of 92 consecutive patients who underwent multilayered fetoscopic surgical MMC repair using HUC matrix allograft for duraplasty at their institution from December 2016 to March 2022, including more than 24 months of postnatal follow-up.

RESULTS

Of 92 patients who underwent fetoscopic MMC repair, 88 had duraplasty using cryopreserved HUC matrix allograft. Fifty-seven patients had at least 24 months of follow-up data. The mean gestational age at the time of surgical repair was 24.8 ± 0.7 weeks. The average operative time from skin incision to closure was 260 ± 43.4 minutes, in which 79% of this time was used for the fetoscopic portion. No patient required intraoperative emergency delivery. At birth, there were no cases of CSF leak or complete wound dehiscence. Six (11.5%) of 52 patients experienced superficial wound dehiscence, and only 2 (3.5%) required surgical revision. At 30 months, 54.8% of patients were noted to be independent ambulators, 35.5% were therapeutic ambulators, and 9.7% remained wheelchair users in this subset of patients. The rate of hydrocephalus requiring CSF diversion was 35.3%, and 84.3% of patients had complete reversal of hindbrain herniation at birth. Eight (15.7%) of 51 patients had spinal inclusion cysts noted on routine follow-up spinal imaging, but only 2 (3.9%) required surgical intervention due to radiological progression without neurological symptoms.

CONCLUSIONS

A laparotomy-assisted, 3-miniport fetoscopic approach for prenatal MMC multilayered repair offers excellent access and visualization for an effective watertight closure. The use of HUC matrix allograft as a dural substitute was shown to be effective with a low rate of neurosurgical postnatal complications.
Numerical Simulation of the Diffusion of Electroactive Molecule in Biosimilar Hydrogel Media
Authors: Cherenkov I. A , Krivilev M. D , Ignat'eva M. M , Emel'yanova A. Yu , Sergeev V. G
Published: November 2024

Based on experimental data of cyclic voltammetry, the values of the diffusion coefficients for toluidine blue in alginate hydrogel, gelatine hydrogel and alginate-gelatine hydrogels were obtained. Using the experimental values of the coefficients in a numerical model, the values of the recovery of flows have been calculated showing them consistent with what was the experimental. It is proposed to use the period in time during which the value of the flow force reaches the value of steady state flow force as an indicator of the diffusion properties of the hydrogel medium. The findings of this study can be used for the development of methods for the evaluation of the diffusion properties of hydrogel media: bioinks and tissue-engineered structures.
Comparative Evaluation of Interaction Force Characteristics for the Lipopolysaccharide of Yersinia pseudotuberculosis and Antibodies by Optical Trapping and Atomic Force Microscopy
Authors: Byvalov A. A , Belozerov V. S , Konyshev I. V , Ananchenko B. A
Published: November 2024

Optical tweezers and atomic force microscopy were used for comparative evaluation of the interaction force between the lipopolysaccharide of Yersinia pseudotuberculosis and monoclonal antibodies. This paper discusses the peculiarities of two methods which allow determining significant differences in the values of the measured force required to rupture the interaction of probe sensitized by lipopolysaccharide (polystyrene microsphere for optical tweezers and silicon nitride cantilever for atomic force microscopy) with substrate (glass and mica, respectively) covered with monoclonal antibodies. In atomic force microscopy, the cantilever slides along the substrate for some time after the piezo stage is brought to a stop, causing changes in the spatial structure of sensitins and, therefore, redistribution of multiple bonds between the lipopolysaccharide agglomerate and antibodies. No significant displacement of the microsphere along the substrate occurs when an optical tweezers setup is used, and, unlike atomic force microscopy, the breaking of a complex bond between lipopolysaccharide and complementary antibodies is recorded in the form of a single and short-term (1–2 ms) leap of the photodetector signal employing optical tweezers. The recorded values of the force required to rupture the interaction measured by both methods are relative and vary depending on the chosen experimental conditions. It is shown that the non-specific component of the force needed to break the interaction measured by atomic force microscopy is significantly higher than that determined with optical tweezers.
FT-IR Difference Spectroscopy for Studying the Secondary Structure of the Membrane Protein Bacteriorhodopsin When Submitted to Microwave Radiation at 8–18 GHz
Authors: Terpugov E. L , Degtyareva O. V , Fesenko E. E
Published: November 2024

Fourier transform infrared (FTIR) difference spectroscopy was used to study the effects of microwaves radiation on the structure of bacteriorhodopsin under light condition. The detailed FTIR spectral analysis revealed the pronounced structural changes in amide I and amide II regions as well as the rearrangements of the hydrogen-bonding network. Well-resolved peaks of amide bands allow accurate determination of two different components (α-I and α-II) of an α-helical conformation of opsin. Irreversible conformational changes of bacteriorhodopsin in purple membranes, detected by FTIR difference spectroscopy, suggest that regardless of temperature, microwaves induce protein structural rearrangements.
Study of Cytotoxicity of Selenium Nanoparticles Synthesized Using Artificial Metal-Binding Tumor-Specific Protein W8-3C
Authors: Pozdnyakova N. V , Biryukova Yu. K , Sokolova Z. A , Baryshnikova M. A , Shcherbakova E. S , Smirnova M. S , Shevelev A. B
Published: November 2024

For the first time, the pW8-3C construct encoding the artificial tumor-specific protein W8-3C with the addition of 3 residues of free Cys at the C end was created and described. Using purified W8-3C protein, dispersions of nanoparticles 75.24 nm in diameter at polydispersity index (Pdi) of 0.064 and Se content of 1566 µg/mL were obtained and characterized for the first time. The dispersions remained stable upon storage for 6 months at +4°C. For comparison, the maximum Se content in the nanoparticle dispersion obtained in the presence of W8-3C protein and Pluronic F-127 was 399 µg/ml. The cytotoxic activity of the obtained nanoparticles was studied on transplanted cells of human tumor lines: HeLa (cervical carcinoma), U-87 MG (glioblastoma), MCF-7 (breast carcinoma) and HCT-116 (colon carcinoma) and compared with that on the diploid human fibroblast line WI-38 in vitro. It was shown that the IC50 of Se nanoparticles obtained using the W8-3C protein for tumor lines ranged from 5.25 to 8.37 µg/ml, while the IC50 for normal fibroblasts was 14.3 µg/ml (difference in values by a factor of 1.7–2.7 times).
Parameterization of a Model for Wild Chickpea Flowering Time by Transferring the Knowledge Learned from Multiple Sources
Authors: Saranin Z. A , Samsonova M. G , Kozlov K. N
Published: November 2024

Building forecasting the flowering time helps researchers to create varieties with maximum efficiency and value under a changing climate. This paper proposes an algorithm for parameterization of the wild chickpea flowering time model by using machine learning through knowledge transfer to combine multiple input-target sets. The resulting model showed high accuracy based on genetic and climatic data on only the first 20 days after sowing – the average absolute error is slightly greater than 5 days, the Pearson correlation coefficient is 0.93. It was found that maximum and minimum temperatures have the strongest effect on the timing of flowering. At the same time, all weather factors by the 7–10 day from the date of sowing affect a solution of the model.
Influence of Mobile Phone Electromagnetic Radiation Exposure on Behavior of Protozoan Population
Authors: Morozova L. A , Savel’ev S. V
Published: November 2024

For the first time, the effect that mobile phone electromagnetic radiation had on water in the presence of protozoan population and induced a significant change in water properties has been experimentally studied. The results of our experiment demonstrate that changes that occur in the “water–protozoa population” system are the biological effects the cells have in response to the direct effect of radiation. This conclusion is supported by the fact that the calculated order of magnitude of a time interval during which information exchange takes place between some microorganisms of the protozoan population is the same as that over course of the experiment. The minimum concentration of protozoa (1000 pcs/liter) at which this effect was observed was determined. It is concluded that the proposed technique for alteration of physical properties of water in the presence of protozoan population after exposure to electromagnetic fields can be used to uncover the mechanisms of the interaction of biological systems with electromagnetic fields.
Study of Peculiarities of the Formation of Behavioral Skills in Rats in the Three-Arm Maze
Authors: Dragan S. P , Komarov D. B , Veselovsky I. A , Bogomolov A. V
Published: November 2024

The aim of our experimental research was to explore the formation of behavioral skills such as active avoidance learning in different species of rats in the three-arm maze. To determine which species is the most trainable, our study used 100 white outbred, 30 Long Evans and 30 Dumbo rats. The conditioned stimulus was a combination of playing the sound and turning off the light in a randomly selected target arm of the maze. 5 sec after the buzzer started to sound the light was turned off, then an unconditioned stimulus, the electric power, was applied to non-target arm, and the light was turned on. The task of the rat was to change the arm and enter the target (safety) arm of the maze after the sound stimulus. When the task was done, the floor of non-target arm was not charged furhter and the light was turned off. The interval between conditioned/unconditioned stimulus combinations was 30 s, it took 1 month to train each rat species and 20 sessions with different combinations of stimuli were used every day. The rat was considered trained when the probability of achieving the goal within a time limit not exceeding 6 s is 70% or higher of cases. It has been found that Dumbo rats are the best animals to train quickly in large groups to respond to an irritating stimulus.
Regular Quaternion Equations of the Spatial Hill Problem in Kustaanheimo–Stiefel Variables and Quaternion Osculating Elements
Authors: Chelnokov Yu. N.
Published: November 2024

Regular quaternion equations of the spatial Hill problem (a variant of the limited three-body problem (Sun, Earth, Moon (or another low-mass moving cosmic body under study)) are obtained, when the distance between two bodies with finite masses is considered very large, in four-dimensional Kustaanheimo-Stiefel variables (KS-variables) within the framework of the elliptical and circular spatial bounded three-body problem, as well as the regular quaternion equations of the planar Hill problem in two-dimensional Levi-Civita variables. In these equations, the variables are KS-variables or Levi-Civita variables and the energy of relative motion of the body under study, or a variable that converts for the circular Hill problem into a constant of motion of this body (the Jacobi integration constant), as well as the planetocentric distance of the Sun and real time associated with a new independent variable by the Sundman differential transformation of time or other more complex differential ratio. These equations are supplemented by the equation of the Earth’s orbit in polar coordinates and the equation for the true anomaly characterizing the Earth’s position in the orbit. The first integral of the obtained equations in KS-variables in the case of a circular problem is established. Another first partial integral in the general case is a bilinear relation connecting KS-variables and their first derivatives. Three new forms of regular equations of the spatial Hill problem in quaternion osculating elements (slowly changing quaternion variables) are proposed. The proposed regular quaternion equations have an oscillatory form or the form of equations with slowly changing variables, which makes it possible to effectively use analytical and numerical methods of oscillation theory and methods of nonlinear mechanics in the study of the Hill problem.
To the Charged Surface Instability Calculation of a Stratified Fluid
Authors: Belonozhko D. F.
Published: November 2024

The conditions for the development of instability of the charged surface of a stratified fluid in relation to an overload of surface charge are calculated analytically. A rule for selecting the roots of the dispersion equation is formulated to correctly describe the spectrum of wave motions on the free surface.
The Phase Structure of Wave Disturbances Excited by a Pulsating Source at the Interface of a Liquid Flow of Finite Depth and an Ice Sheet
Authors: Bulatov V. V. , Vladimirov I. Yu.
Published: November 2024

The floating ice sheet determines the dynamic interaction between the ocean and the atmosphere, affects the dynamics of the sea surface and subsurface waters, since the ice sheet and the entire mass of liquid under it participate in the general vertical movement. The paper investigates the phase structure of wave fields arising at the interface between ice and a flow of homogeneous liquid of finite thickness when flowing around a localized pulsating source of disturbances. The ice sheet is modeled by a thin elastic plate, the deformations of which are small, and the plate is physically linear. An integral representation of the solution is obtained, and the results of calculations of dispersion dependencies and phase patterns for various parameters of wave generation are presented. It is shown that the main parameters determining the characteristics of the amplitude-phase structure of wave disturbances of the ice sheet surface are ice thickness, flow velocity, and pulsation frequency. Numerical calculations demonstrate that when the flow velocities, ice thickness, and frequency change, there is a noticeable qualitative restructuring of the phase patterns of the excited long-range wave fields at the ice-liquid interface.
Integral Representations of Solution in the Problem on Skew Incidence of a Surface Wave on the Straight Shoreline Water Wedge
Authors: Lyalinov M. A. , Polyanskaya S. V.
Published: November 2024

In the linear approximation of the surface gravitational waves of small amplitude a classical model problem about the incursion of a surface wave under some angle on the shoreline is solved. The problem is formulated for the harmonic potential of velocity of the fluid in the 3D water wedge with the Robin-Steklov boundary condition on the free surface and with the no-flow condition along the normal on the bed of the water domain. Some critical comments about a known in the literature solution having a “non-physical” singularity of the logarithmic type on the coastal line are given. The asymptotics with respect to distance from the shoreline of the obtained solution, bounded on the edge, is constructed. The reflection coefficient of the wave reflected from the shoreline is calculated.