bluuebunny/crossref_metadata_2025 huggingface dataset:
Antitumor Activity of Ziziphus Jujube Fruit Extracts in KG-1 and NALM-6 Acute Leukemia Cell Lines
Authors: Manshadi Shiva Mosadegh , Ardekani Mohammad Reza Shams
Published: October 2023

Background: Ziziphus jujube Mill. belongs to the Rhamnaceae family. It has been reported to have a variety of biological activities such as antitumor, antioxidant, and anti-inflammatory effects. This study investigates the antiproliferative effect of Ziziphus jujube on KG-1 and NALM-6 acute leukemia cell lines.
Materials and Methods: In this experimental study, the aqueous, ethyl acetate, and hydroalcoholic extracts of the Ziziphus jujube were prepared. Total phenolic and flavonoid components were detected because the presence of these compounds is associated with antioxidant and anticancer effects. Different concentrations of extracts were prepared, and KG-1 and NALM-6 cell lines were treated with them at 12, 24, 36, and 48 hours. Cell viability and IC50 values of the extracts were calculated using MTT assays. BD Cycle TEST PLUS DNA Kit was used for cell cycle progression analysis. Bcl2, Bax, and caspase-3 mRNA expressions were also assessed.
Results: Cell viability decreased in a concentration-dependent manner. The best efficacy belonged to the ethyl acetate extract. Investigation of cell cycle progression demonstrated that the number of G0/G1 cells enhanced and the number of G2/M cells decreased when the ethyl acetate extract was applied in its IC50 concentration. A considerable increase in Caspase-3 and Bax and a decrease in Bcl2 gene expression were detected in molecular examination.
Conclusion: According to our research, Ziziphus jujube ethyl acetate extract has antitumor properties on KG-1 and NALM-6 cell lines, possibly through induction of apoptosis and cell cycle regulation.
A Study of Association of ABO and Rh Blood Group with Colorectal Cancer in Khuzestan Province, Iran
Authors: Jodat Hosein , Jodat Javad , Khodadadi Ali , Talaiezadeh Abdolhassan , Joudaki Nazanin , Asadirad Ali
Published: October 2023

Background: Colorectal cancer, a solid tumor with a high prevalence, contributes significantly to annual mortality rates. Various factors, including blood groups, may influence cancer risk. Multiple studies have suggested a potential connection between ABO and Rh blood groups and colorectal cancer risk. This study aims to investigate the role of ABO and Rh blood groups as risk factors in colorectal cancer patients.
Materials and Methods: We conducted a retrospective study involving 71 colorectal cancer patients diagnosed between 2018 and 2020 in Khuzestan province, Iran, with known ABO blood types. Large-scale data from 29,922 blood donors in Khuzestan served as the healthy population control. The study analyzed the distribution of ABO blood groups among the blood donors.
Results: Our findings revealed that the distribution of blood groups among colorectal cancer patients was as follows: O (31.0%), A (29.6%), B (29.6%), and AB (9.8%). However, our analysis did not establish a significant association between colorectal cancer risk and ABO antigens (P-value = 0.636) or Rh blood group (P = 0.198). Additionally, no significant differences in ABO blood types were observed concerning gender (P = 0.802), cancer type (P = 0.338), or tumor type (P = 0.207) among colorectal cancer patients.
Conclusion: This study does not support a significant correlation between ABO and Rh blood groups and the risk of colorectal cancer, nor does it find associations with cancer type or tumor type.
No Association of AS3MT Gene Polymorphisms with Susceptibility to Hepatotoxicity and in APL Patients Treated with AS2O3: A Single Center Study
Authors: Joneidi Zeinab , Mortazavi Yousef , Chahardouli Bahram , Rostami Shahrbano , Vaezi Mohammad , Nabipour Majid , Biglari Alireza , Ghavamzadeh Ardeshir
Published: October 2023

Background: Arsenic three oxide (As2O3) is the treatment choice for acute promyelocytic leukemia (APL). Little is known about possible risk factors with predictive value for toxicity caused by As2O3. Biomethylation is considered to be a major pathway of detoxification for inorganic arsenics (iAs). Arsenic Methyltransferase (AS3MT) is one of the key enzymes involved in the transfer of a methyl group from S-adenosyl-L-methionine to trivalent arsenical and plays a critical role in arsenic detoxification. Polymorphisms in hAS3MT lead to a change in the catalytic activity of the enzyme and may increase the risk of arsenic-related toxicity. In this study, we investigated the association of the AS3MT polymorphisms (rs11191439, rs3740390, and rs3740393) genes with hepatotoxicity in APL patients treated with As2O3.
Materials and Methods: Genotyping was performed in 140 adult patients with APL treated with As2O3 using PCR-RFLP for rs11191439 and tetra-primer ARMS-PCR for rs3740390 and rs3740393. The results of PCR-RFLP and ARMS-PCR were confirmed by direct sequencing of 10 % of DNA samples. The results were analyzed using SNPStats, SPSS, and FinchTV. Hepatotoxicity was graded according to the National Cancer Institute's Common Toxicity Criteria (CTC).
Results: Hepatotoxicity was seen in 52 of the 140 patients (37.1%), with grades I and II hepatotoxicity in 40 (28.6%) and grades III and IV hepatotoxicity in 12 (8.5%) patients.  The association between the three polymorphisms and hepatotoxicity was evaluated using five genetic models and none of the three studied polymorphisms were significantly associated with hepatotoxicity.
Discussion: The results of our study showed that AS3MT rs11191439, rs3740390, and rs3740393 polymorphisms are not associated with hepatotoxicity in APL patients. Genetic polymorphisms in enzymes which are involved in arsenic metabolism have been shown to have ethnicity and race-related differences. To more precisely characterize the association between AS3MT gene polymorphism and hepatotoxicity, future large-scale studies in non-Asian populations and other ethnicities are needed.
The potentially nephrotoxic substances in food: a review
Authors: Sadighara Parisa , Mohammadi Sara , Irshad Namra , Sadighara Melina , Ramezankhani Reyhaneh
Published: October 2023

Food is the most unavoidable substance for contamination. It can be contaminated naturally and unintentionally by toxins. Some of these food contaminants contain nephrotoxins. For this purpose, a narrative review study was performed to identify the types of nephrotoxin found in food. This study was performed with the keywords; nephrotoxin, contamination, pollution, and food. The nephrotoxic toxins consist mainly of three categories of toxins; mycotoxins, heavy metals, and Aristolochic acids. About 70% of the selected studies investigated ochratoxin A (OTA). Evaluation of OTA contamination in baby food and infant formula should be considered. From the category of nephrotoxic heavy metals in food, we can mention nickel, lead, and cadmium. Also, from compounds with radionucleotide activity, contamination with uranium was observed. Onions and carrots can be good biomarkers for contamination of an area with Aristolochic acids. Some of the nephrotoxins occurred more than permissible levels. Given that the kidneys are a vital organ of the body, therefore, human biomonitoring of nephrotoxins is recommended in countries where food is over the permissible level.
Prevalence and antibiotic susceptibility of Listeria innocua in seafood from selected markets of Lagos, Nigeria
Authors: Amusan Esak Ester , Sanni Abiodun , Onipede Gbemisola
Published: October 2023

Listeria is a bacterial genus that is widely distributed in fish and fishery products and is a vehicle for food-borne bacterial infections and intoxications. Listeria innocua, though considered nonpathogenic, is a close relative to L. monocytogenes a known food-borne pathogen. It has been implicated in the transfer of antimicrobial-resistant genes. Therefore, this study investigates the prevalence of Listeria innocua and its antimicrobial susceptibility pattern in seafood found in Badagry, Iyana Ipaja, Liverpool, Makoko and Mushin, Nigeria. A total of 500 samples comprising of fresh and smoked blue whiting, croaker and shrimps were collected aseptically from retail outlets across Lagos. Culture, biochemical and sugar tests were carried out to identify L. innocua. 16S rRNA gene sequencing was conducted to confirm the isolates as L. innocua. The antimicrobial susceptibility testing was determined by the disk diffusion assay. Out of 500 seafood samples analysed, 36 (7.2%) were positive for Listeria innocua. Raw croaker had the highest occurrence of 13.0%. The antimicrobial susceptibility test revealed that all isolates were resistant to ceftazidime and cloxacillin. However, high sensitivities to ofloxacin (83.3%) and erythromycin (72.2%) were exhibited by the isolates. The recovery of these antimicrobial-resistant Listeria innocua strains in the seafood samples analysed warrants the need for suitable control procedures as this could constitute a great risk to public health.
Microbial load and aflatoxin contamination in locally formulated herbal mixtures obtained from Itoku market, Nigeria
Authors: Oni Eniola Oluyemisi , Oni Nathaniel Olorunsogo , Bamidele Julius , Taiwo Odunayo Anthony , Blessing  Oyetibo Olubukola , Badmos Amina Omodolapo , Adeleye Tolulope Modupeolu , Olatunbosun Mariam Omobolanle , Oluwafemi Flora
Published: October 2023

Contamination of locally formulated herbs with aflatoxins and pathogenic organisms poses major health concerns to humans and animals, especially in recent times when herbal mixtures are on the rise. This study aimed to determine the herbs' microbial profile and aflatoxin level. Two different herbal medicines (malaria and typhoid; each prepared with water and alcohol) were obtained at Itoku market, Ogun-state, Nigeria. The samples were isolated using the serial dilution technique and isolates were identified morphologically. Aflatoxin quantification was done on the herbal samples using High-Performance Liquid Chromatography (HPLC). The viable bacteria count ranged from 1.0×105 cfu/g to 20.0×105 cfu/mL with the typhoid herbs prepared with water recording the highest count. The microorganisms obtained in the herbs were confirmed as, Escherichia coli, Staphylococcus aureus, Micrococcus luteus, Salmonella sp, Proteus sp, Aspergillus flavus, Penicillium chrysogenum, Saccharomyces cerevisae and Fusarium sp. Typhoid herbs prepared with water showed high aflatoxin detection limits of 7.60 μg/mL. The result showed that the locally formulated herbs were highly contaminated with microorganisms and that consumption of the locally formulated herbs with aflatoxin could cause aflatoxicosis.
License obligation for bread safety and business and the effect of bakeries using oven under the building in earthquake damages; a case of February 2023 Earthquakes, Türkiye
Authors: Özçakmak Sibel , Molaee-Aghaee Ebrahim , Yıldız Hüseyin
Published: October 2023

Food and water supply is important for people's health affected by earthquakes. Food manufacturing areas must be built earthquake-resistant and in accordance with the conditions specified in the legal legislation to provide food security and safety through disasters. A bread and bread varieties business using ovens could be damaged and pose a risk to their neighborhood due to their activities. Production of bread and bread varieties using stone/wood ovens could cause the separation of iron from concrete with the effect of warming and cooling. This study aimed to evaluate the impact of bread and bread varieties businesses located at the entrances of the apartments on the destruction or damage of buildings caused by earthquakes and lack of access to enough safe food. Therefore, the damage to buildings with stone/wood ovens at apartment entrances caused by the earthquake that occurred in Türkiye on 6 February 2023 was evaluated. Some bread producers with ovens that have no independent structures and obtained licenses before the regulation dated 2014, should determine their infrastructural features. Using stove/wood ovens under or at the entrance of the apartments in bakery places could be a risk of causing damage to the column structure. The inspections of bakery places of the municipality and the other authorized organizations must be done more often, and official monitoring should be mandatory for food and environmental safety.
Letˋs Pay Attention to Covid and Move Forward
Authors: T. Avramov
Published: October 2023

Introduction: Zoonoses are diseases transmitted from animals to humans and pose a major threat to human health and life. Animals are often asymptomatic carriers of pathogens and spread them in the environment with their excreta. Their course varies from the common cold to more severe and often fatal diseases in humans. Before the COVID-19 infection caused the global pandemic in 2020, coronavirus diseases were primarily of veterinary interest.
The COVID-19 pandemic has changed the way we live and strained healthcare systems around the world. This pandemic has necessitated the development of protective and therapeutic measures against the spread of SARS-CoV-2. The lack of optimal vaccine against SARS-CoV-2 offering long-lasting protection against the different viral variants, as well as a drug, allowing the treatment of all variants of COVID-19 directed us to the use of dietary components and agents that are applicable in the context of competitive inhibition by blocking part of the receptors to protect against coronavirus-related diseases.
Discussion: Lactobacillus and carrageenans may have a protective effect against SARS-CoV-2 infection alone or in combination in healthy subjects. Reducing the viral load in the nasopharynx may drastically reduce the risk of transmission of COVID-19.
Infectious diseases are among the strongest types of selective pressure driving human evolution. Genetics in the coming decades will likely allow us to understand the dynamics of human immune system formation. By learning from our mistakes and successes, we will be able to more successfully deal with the challenges posed by zoonoses in the future.
Investigation of nonlinear deformation and stability of a composite cylindrical shell under combined loading with torque, edge transversal force and internal pressure
Authors: Zheleznov L.P.
Published: October 2023

The paper presents a finite element formulation for solving stability problems of the composite cylindrical shells taking into account momentness and nonlinearity of their subcritical stress-strain state. The nonlinear problem of strength and stability was solved by the finite element methods and the Newton-Kantorovich linearization. Critical loads were determined in the process of solving the geometrically nonlinear problem using the Sylvester criterion. Finite elements of the composite cylindrical shells with natural curvature previously developed on the basis of Timoshenko’s hypothesis were used. Their rigid motions were explicitly identified in the movement approximation. Stability of a circular cylindrical shell made of the polymer composite material was studied under combined loading with torque, transverse force and internal pressure. Interaction curves of the external loads were obtained. Influence was determined of monolayers laying methods, nonlinearity of deformation and internal pressure on the critical loads of the shell buckling and the weight efficiency of composite shells in comparison with the metal ones.
Studying the impact of the optimal control problem components on its frequency for a quadruple walking robot
Authors: Khusainov R.R. , Linyushin A.A. , Vorochaeva L.Yu. , Savin S.I.
Published: October 2023

There exist a large number of classes of the walking robots differing in the number of limbs, principles and modes of motion and control. Each class of robots has its own advantages and disadvantages depending on the tasks to be solved. A quadruple walking robot is considered capable of moving over the rough terrain. Its advantages over the biped systems include higher stability, and over the six- and eight-legged systems - simpler control due to the smaller number of limbs, and the possibility of using animals as the prototypes. One of the important and not completely solved problems is development of approaches to control a quadruple walking robot, as well as establishing the influence of computational complexity of the control system separate elements on its overall operation frequency. Such robot control system is represented in the form of three modules: inverse kinematics, predictive control and model parameters calculation. Each module requires solving a certain problem. A study was conducted on the time distribution between the control system modules in a single iteration. Average time distribution values and their standard deviations were determined for the two robot motion modes: standing and walking. Results of the numerical experiments established that the standard deviations were not depending on the device motion mode, which indicated independence of the computational load created by the control system on the robot motion mode.
Investigation of properties of the regular structures obtained by additive technologies in combination with the powder metallurgy methods
Authors: Gordeev Y.I. , Binchurov A.S. , Moskvichev Е.V. , Zeer G.M. , Zelenkova E.G. , Yasinsky V.B.
Published: October 2023

Despite significant amount of research and applied works in the additive technologies, problems of the topological optimization of structures obtained by combining 3D printing and the powder metallurgy methods remain insufficiently studied both theoretically and experimentally. Results of simulating regular structures made of plastics and studying their destruction processes could be effectively used as a starting approach in developing technology for production of the composite materials based on the titanium alloys with the increased level of strength properties. Based on numerical experiments and full-scale tests, the most preferred types of structures were determined. They include honeycomb structures based on PLA with the following strength properties: elastic modulus — 342.3 MPa; ultimate compressive strength — 20.4 MPa; specific strength — 81 MPa cm3/g. 3D models realized on plastics were used in manufacture of the metal composites using technology combining selective laser melting and powder metallurgy. In addition to increasing density and eliminating porosity of structures made from the titanium alloy powders, the strength properties level also increases after infiltration with the lower-melting alloys, since redistribution of stresses arising in the titanium frame under load is ensured. Bending strength alters in the range of 1140...1560 MPa and elastic modulus - in the range of 49 500...54 000 MPa depending on the composite composition and selective laser melting modes. Rockwell hardness increases from 35 to 45 HRC, and Brinell hardness — from 340 to 410 HB, which is by 20...25 % higher than hardness of the rolled products from the VT6 alloy. The increased strength values could be explained by the material composite structure formed by combination of the two mutually penetrating frames. Results of testing samples for strength are another argument in favor of the proposed infiltration method implying combined additive and powder metallurgy methods.
Improvement of the gas separator flow path using the multiphase coefficient of the discrete particles relative motion speed
Authors: Trulev A.V. , Timushev S.F. , Lomakin V.O. , Klipov A.V. , Shmidt E.M.
Published: October 2023

The paper analyzes features of the flowing formation fluid that contains free gas bubbles in the flow part of a vortex-type separator with the movable screw. Expressions are derived for a dimensionless multiphase coefficient of the discrete particles relative separation rate and the multiphase similarity criterion, which are making it possible to evaluate the gas separator efficiency, design and develop new devices based on the previously created highly efficient models. The derived equations allow determining the main geometric dimensions of the gas separator flow part based on the given radial dimensions, nominal flow rate and permissible content of free gas at the inlet. For the obtained geometric dimensions of the gas separator flow part, it becomes possible to construct dependences of the separation coefficient and the permissible amount of free gas at the inlet on the rotor rotation speed, flow rate and physical properties of the multiphase mixture.
Methods for calculating fuel heating at injection with pressure of up to 400 MPa in a diesel engine
Authors: Grekhov L.V. , Markov V.A. , Onishchenko D.O. , Moiseev D.A.
Published: October 2023

The study is driven by the trend of the rapidly growing injection pressure in diesel and gasoline engines with fuel injection into the combustion chamber. Experimental results were obtained by pouring fuel through a model nozzle and through the electrohydraulic diesel injectors. The paper describes reasons for the fuel significant heating at the injection and proposes its mathematical substantiation. For different tasks and fuels, three methods for the heating calculation during fuel injection at the ultra-high pressures were demonstrated. It was revealed that most important was fuel heating by the Joule-Thomson effect in the injector nozzle. Due to action of several heat release factors, fuel temperature could reach 240...260°C at the injection pressure of 350...400 MPa. The paper proposes most convenient relationships for computational analysis of the thermal conditions of the fuel supply process. Fuel heating assessment makes it possible to find the boundary conditions for calculating the intra-cylinder processes and the fuel outflow crisis at the ultra-high pressures.
Printed circuit board stress strain strength analysis using the particle approach
Authors: Arinchev S.V.
Published: October 2023

Traditionally, the load-carrying printed circuit boards are applied as an electrical engineering device. At the same time, the promising nanosatellites are using them as the spacecraft load-bearing structural elements. The printed circuit board is able to accommodate a relatively heavy solar cell, rotating gyroscopes and a folding antenna. Load-carrying board strength calculation is a complicated task, as a large number of stress concentrators and structural defects are effecting its surface. This makes it difficult to use the traditional concept of “stress at a point” applicable in continuous and differentiable media. In this regard, the paper proposes to introduce the concept of the “model rupture-start time moment for a given particle pair”. Calculations show that even slow loading of the model under consideration leads to extremely intense particles motion, i.e. the static loading hypothesis does not work. To analyze strength of the board under consideration, the Cauchy problem with initial conditions was formulated. The problem solution convergence based on the number of particles in the model was analyzed. The paper shows that the convergence rate is quite high, and to solve the problem under consideration it is sufficient to take a model containing about 100 particles.
Sosyal Medya Kullanım Amaçları Ölçeği: Üniversite Öğrencileri Üzerinde Bir Validasyon Çalışması
Authors: ÖKTEN Mehmet Salih
Published: October 2023

Sosyal medya platformlarının hızlı büyümesi, insanların iletişim kurma, bilgi edinme ve kendini ifade etme şekillerini dönüştürdü. Farklı kullanıcı grupları arasında, üniversite öğrencileri sosyal medyayla aktif olarak etkileşim kuran önemli bir demografik gruptur. Üniversite öğrencilerinin sosyal medya kullanımının motivasyonlarını ve amaçlarını anlamak, araştırmacılar, eğitimciler ve platform tasarımcıları için önemlidir. Bu makale, Üniversite Öğrencilerinin “Sosyal Medya Kullanım Amaçları Ölçeği”nin (SMKAÖ) geliştirilmesini amaçlamaktadır. Bu ölçek, üniversite öğrencilerinin sosyal medya platformlarını nasıl ve hangi amaçlarla kullandıklarını belirlemek, kullanım motivasyonlarını ve tercihlerini saptamak amacıyla tasarlanmıştır.
Ölçeğin saha çalışması, Türkiye’nin yedi farklı coğrafi bölgelerinde ve KKTC’de bulunan toplam 70’in üzerindeki üniversitede ön lisans, lisans, yüksek lisans ve doktora düzeyinde örgün öğrenim gören 293’ü kadın ve 200’ü erkek olmak üzere toplam 493 sosyal medya kullanan öğrencilerin katılımıyla gerçekleştirilmiştir. Evren içindeki her tabakanın (bölgenin) örneklemde anlamlı ve gerekli bir büyüklükte temsil edilmesi arzu edildiğinden orantısız tabakalı örnekleme yöntemi tercih edilmiştir.
Elde edilen veriler, istatistiksel analizlere tabi tutulmuş ve ölçeğin iç tutarlılık ve faktör yapısı gibi istatistiksel analizlerle değerlendirilmiştir. Ölçeğin Cronbach Alpha iç tutarlılık katsayısının 0,904 olarak hesaplanması, ölçeğin öğeleri arasındaki ilişkinin oldukça güçlü olduğunu göstermiştir. Faktör analizi sonucunda ise ölçeğin kullanım amaçlarını belirlemek için geçerli ve güvenilir bir araç olduğu görülmüştür. Analiz sonuçlarına dayanarak SMKAÖ, 18 maddeden ve dört ayrı faktörden meydana gelmiştir.
Adoption of Scientific Fish Farming of Pengba (Osteobrama belangeri) by the Fish Farmers in the Valleys of Manipur
Authors: Naresh Khuman Oinam , Singh Y. J. , Sarkar A. , Patel A. B. , Pal P. , Bharati H. , Singh K. , Pegu C. , Borah K.
Published: October 2023

The present study examined the extent of adoption of scientific fish farming of Pengba (Osteobrama belangeri) by the fish farmers in the valleys of Manipur. Three districts viz., Bishnupur, Imphal West and Thoubal were purposively selected for the study. A sample size of 80 respondents was selected after consultation with Department of Fisheries, Government of Manipur and with the village key informants. Pre tested and structured interview schedule was administered for data collection. The study found that only 40.06 per cent of the respondents had fully adopted the scientific fish farming of Pengba. The variables such as experience in fisheries activities, knowledge level, family size, annual income and scientific orientation had significant and positive relationship with the extent of adoption of scientific fish farming of Pengba. This study also revealed that knowledge level, scientific orientation, annual income and family size were the best predictors to the total explained variation of 52.50 per cent to the extent of adoption of scientific fish farming of Pengba.
Sequence Characterization of Anti Tumorigenic (IL12B) and Pro Tumorigenic (IL17A) Ovine Interleukins for an Immune Approach to Cancer Immunotherapy
Authors: Gaur Kritika , Anuradha J. , Pratap Singh Vivek , Meena A. S. , Kumar Rajiv
Published: October 2023

Cancer is a complex illness characterized by uncontrolled cell growth and the spread of abnormal cells throughout the body. Immunotherapy is one of the cancer treatment modalities gained prominence in recent years. Immunotherapy is a type of bio-therapy that works by retraining the patient's immune system to recognize cancer, boosting selectivity, and decreasing side effects. Immune modulation is a complex process involving several cell types and factors. High-dose of IL-12 provides long-term responses in a subset of patients with metastatic melanoma and renal cell carcinoma. IL-17 has been identified as a frequent cytokine in the tumour microenvironment that can have dual roles in cancer growth and tumour eradication. In present study, ovine Interleukin 12B and 17A genes were amplified, cloned, and in silico analyzed for its potential in cancer treatment.
Major Histocompatibility Complex-DQA Variants Analysis: Rich Repertoire with Selection Advantages and Disadvantages
Authors: Mishra Amit , Kumar Rajiv , Sharma Ravi Kumar , Singh Meena Amar , Gaur Kritika
Published: October 2023

Insulin dependent diabetes mellitus, an autoimmune disorder in human being, is associated with MHC class-II, which reacts with auto peptide released by MHC class-II. HLA-DQ alleles (DQA1 and DQB1) are revealed to be linked with type 1 diabetes in humans. The DQ alleles passed from parents to the offspring predisposes them with risk of type I diabetes. In present study, DQ variants (DQA1 and DQA2) were amplified and sequenced with product size 826 bp (DQA1) and 865 bp (DQA2) from sheep’s blood. Sequences were insilico characterized for percent identity, phylogeny, and protein property. Phylogeny analysis suggests a rich repertoire of DQA alleles in sheep. Ramachandran plot analysis had shown the residues are occurring under the core region of both the DQ loci with 90.8% and 92.1% of residues lie in the favored region in DQA1 and DQA2 loci, respectively.
Impact of Organic Starter Solution on Vase Life of Chrysanthemum (Dendranthema grandiflora Tzvelev)
Authors: Chouhan Ankita , Tirkey T. , Sharma G.
Published: October 2023

The present investigation entitled “Impact of organic starter solution on vase life of chrysanthemum (Dendranthema grandiflora Tzvelev)” was carried out at Department of Floriculture and Landscape Architecture, College of Agriculture, Indira Gandhi Krishi Vishwavidyalaya, Raipur during 2018-19. The experiment was laid out in Completely Randomized Design with thirteen treatments and three replications consisting of organic starter solution alone and in combination with PSB and Trichoderma. The purpose of the experiment was to evaluate the result of applying organic starter solution in plants, comparing it to inorganic starter solutions to evaluate the vase life of chrysanthemum grown in potted condition. Studies showed organic starter solutions significantly improved the freshness of flower over control. Maximum vase life (19.67 days) was recorded at application of treatment T8 (Goatery slurry + PSB) which was significantly superior over all the other treatments including control. Minimum vase life (17.20 days) was recorded in the treatment T13 (RDF 2% inorganic liquid19:19:19) taken as control.
Standardization of Age of Kokum Seedling (Garcinia indica Choisy) for Transferring in Polybag
Authors: Pralhadrao Debaje Prashant , Gawankar M. S. , Naik H. P. , Haldavanakar P. C. , Khandakar G. , Haldankar P. M.
Published: October 2023

The demand of kokum graft, as well as, seedlings, is more in konkan region and Maharashtra, Goa region. To fulfill the demand, as well as for healthy grafts the experiment was laid out at AICRP Oil Palm, College of Horticulture, Mulde along with 12 treatments and 2 replications. Fresh clean seeds of ripe kokum fruits were sown on nursery bed and after germination they were used for transferring in 6x8’’poly bags having 4x6’’Soil +FYM +Rice husk+2gm VAM (2:1:1). As per T1 treatment some seeds sown directly in poly bag, some seedling transfer as per treatments after sprouting T2, 10 days T3, 20 days T4, 30 days T5, 40 days T6, 50 days T7, 60 days T8, 70 days T9, 80 days T10, 90 days T11, 100 days seedling T12. Observation were recorded at 30,180,270 and 360 days after transferring in poly bags. The result recorded that T3 10 days seedling recorded significantly minimum days to attain the graftable stage i.e., 173 days after transferring along with highest percentage of survival 98.17 %.
Estimation of Soil Temperature and Moisture Using STM Model in Varanasi District of Uttar Pradesh, India
Authors: Singh Bhavna , Nema A. K. , K. Srivastava Prashant
Published: October 2023

The STM2 is a simple and potentially useful tool for modeling soil moisture and temperature conditions to plan agricultural management operation. The quality of STM2 soil moisture estimates varies with soil textural groups. The model worked best with the Sandy and Loamy soil textural groups, which had the lowest RMSE values and the highest d indices. Its moisture estimates were only moderately good for the Clayey soil, and they were unacceptable for the Gravelly soil. Addition of data on the percentage of coarse fragments in the soil or PTFs based on gravelly soil types would probably improve soil moisture prediction. The quality of soil temperature estimates was not as dependent on the soil textural group. In fact, the performance of the model was better for temperature than moisture at all soil types. The quality of soil moisture estimates also generally decreased with increasing depth. Weeds germinate at shallow depths; thus, the model was not designed to estimate conditions at greater depths.
Review on Exogenous Hormone Administration in Aquaculture
Authors: Kranthirekha Mukkeri , Narshivudu Daggula , Mayekar Akshaya Vinod
Published: October 2023

Aquaculture is the fastest expanding sector of animal food production and has a lot of potential as a long term solution for global food security. The ability to controllinggrowth, reproduction and sex is crucial aspects of aquaculture for increasing aquaculture production. Many natural and synthetic hormones are used in aquaculture.This present review focused on the use of various hormones in fish breeding, sex reversal, growth promotion and immune boosting in aquaculture. In fish breeding, pituitary gland extract and gonadotropic releasing hormone analogues are commonly used to induce spawning in captive condition and produce good quantity and quality seed throughout the year. Estrogen and androgen are the mostly used in sex reversal of fish when one gender of species has the potential to grow faster and bigger than other gender.Administration of thyroid hormone and tryptophan helps fish grow bigger and less stressed. In order to increase food safety and limit environmental impact, these hormones should be used with caution in aquaculture. In order to increase food safety and limit environmental impact, these hormones should be used with caution in aquaculture. In order to increase food safety and limit environmental impact, these hormones should be used with caution in aquaculture.
Root and Leaf Phenomenons of C3 Plants Infected with Vesicular Arbuscula Mycorrhizal
Authors: Akhsan Akib Muh. , rawati Syat , Prayudyaningsih Retno
Published: October 2023

The utilization of VAM in plants generally uses powder dosage forms and not yet used dosage forms of sachet and tablet. The research aimed to examine the phenomenon of the roots and leaves of C3 plants infected with VAM in different dosage forms at the screen house scale. The research was conducted at the Agrotechnology Laboratory and Screen House, Faculty of Agriculture, Animal Husbandry and Fisheries, Muhammadiyah University of Parepare, using factorial design. The first factor was the VAM dosage forms, namely powder/control, sachet, and tablet dosage forms. While, other factors were the C3 plant species, namely Puero (Pueraria javanica)/control, mung bean (Vigna radiata), and red spinach (Amaranthus tricolor). The parameter observations on the percentage of infected roots, root volume, leaf area, and stomata density. Data were analyzed using variance analysis. The results showed that the VAM dosage form had a significant effect on all parameters observed with various root and leaf phenomena so VAM in a sachet and tablet dosage form can be recommended as a new dosage form for VAM application in the field.
Management Strategies for Zero Fungicides Residue in Grapes
Authors: Suryawanshi K. T. , Sawant S. D. , Sawant I. S.
Published: October 2023

Research was attempted for growing grapes by using pesticides whenever obligatory and keeping time of applications and choice of pesticides such that at harvest residue will be minimum possible. Strategically outlook for control of diseases was different before fruit set and thereafter. For the management of downy mildew, dithiocarbamate group, such as mancozeb are used, due to which use of bio-control agents as spray was not possible. Induce systemic resistance (ISR) activities of microbes was exploit, to achieve highest ISR activities use of Trichoderma was given before and instantly after fruit pruning. For years, grapes powdery mildew management is dominated by use of trialzole fungicides. But in recent year resistance to triazole fungicides in powdery mildew accentuated up to 50 ppm. Therefore, strategically it was decided that triazole fungicides will not be used 60 days after fruit pruning. The sulfur was safer substitute, an obvious choice which meant if only sulfur was sprayed bio-control agents also can use. Only sulfur and bio-control agents such as Trichoderma and Ampelomyces were used in all FLD locations 60 days after pruning with alternation, till about 15 days before harvest. Based on bio-efficacy experiments chlorine dioxide, nano silver in complex with hydrogen peroxide were selected as ecologically low profile chemicals for management of powdery mildew. In all four FLD plots on this strategy was implemented and in all FLD plots disease PDI for downy mildew, powdery mildew and anthracnose were kept to be bare minimum. Dissipation of pesticide residue in vineyards may be dependent on many factors; microbial degradation is one of such important factors. ICAR-NRCG has developed and commercially formulated Bacillus subtilis name DR-39 applied at 2.5 g/L as effective dose to increase the rate dissipation of about 10 pesticides. Total fungicide residues detected in grapes from different FLD, during 2017-18 was in the range of 0-3. All fungicides detected were below MRLs (Maximum Residue Limits) and their concentrations were very less in parts per billion (ppb) range. The shelf life of the grapes grown in zero residue plots, per cent physiological weight loss (PLW) and per cent rotten berries were found less as compared to farmers practiced plot. The FLDs have success for growing grapes without any detectable pesticides residue (zero residue grapes) by using updated technology and strategy.
Phytochemistry and Therapeutic Applications of Eucalyptus – An Overview
Authors: Suganya S. , Vijayanand S. , Vanmathiselvi K.
Published: October 2023

Eucalyptus globulus, which is commonly seen, has immense potential for medicinal purposes. The blue gum, scientifically called Eucalyptus globulus, is a type of plant that belongs to the Myrtaceae family. It consists of abundant amounts of phytochemical constituents such as flavonoids, alkaloids, tannin, and propanoids which can be found in the leaves, stem, bark and roots of the plant. Multiple researchers have reported the existence of different attributes in these properties, including anti-inflammatory, antibacterial, antiseptic, astringent, anti-diabetic, anti-oxidative, antiviral, antitumor, antihistaminic, anticancer cytochrome p450 inhibitor, and hepatoprotective effects. This review article thoroughly examines different phytochemicals present in Eucalyptus globulusand highlights the various therapeutic uses of these compounds.
As materialidades como um fundamento para o trabalho docente na Educação Infantil
Authors: Pereira Evangelista Lidiane , Vieira da Rosa Alves Camila , Dias Julice
Published: October 2023

Este artigo tem por objetivo apresentar reflexões a respeito da análise da relação curricular entre os elementos estruturais da docência com bebês e as materialidades presentes no planejamento das professoras da Rede Municipal de Ensino de Florianópolis, tomando como base uma pesquisa em nível de Mestrado nos Núcleos Municipais de Educação Infantil. Toma-se como fontes os documentos oficiais e legais que orientam o cuidado e a educação de bebês, crianças bem pequenas e crianças pequenas. E como sustentação teórica ancora-se na produção que se debruça sobre a especificidade da docência com os bebês, a organização dos espaços, ambientes e materialidades na e para a Educação Infantil. O estudo afirma a importância e o sentido curricular das materialidades dispostas aos bebês na organização do trabalho pedagógico.
Palavras-chave: crianças, espaços, docência.
 
Materialities as a foundation for teaching work in Early Childhood Education
ABSTRACT. This article aims to present reflections about the analysis of the curricular relationship between the structural elements of teaching with babies and the materialities present in the planning of teachers of the Municipal Education Network of Florianópolis, based on a research at the Master's level in the Municipal Centers of Early Childhood Education. The sources are the official and legal documents that guide the care and education of babies, very young children and young children. And as a theoretical support, it is anchored in the production that focuses on the specificity of teaching with babies, the organization of spaces, environments and materialities in and for Early Childhood Education. The study affirms the importance and curricular meaning of the materialities arranged to babies in the organization of pedagogical work.  
Keywords: children, spaces, teaching.
 
Las materialidades como base para el trabajo docente en Educación Infantil
RESUMEN. Este artículo tiene como objetivo presentar reflexiones sobre el análisis de la relación curricular entre los elementos estructurales de la enseñanza con bebés y las materialidades presentes en la planificación de los maestros de la Red Municipal de Educación de Florianópolis, a partir de una investigación a nivel de maestría en los Centros Municipales de Educación Infantil. Las fuentes son los documentos oficiales y legales que guían el cuidado y la educación de los bebés, los niños muy pequeños y los niños pequeños. Y como soporte teórico, se ancla en la producción que se centra en la especificidad de la enseñanza con bebés, la organización de espacios, entornos y materialidades en y para la Educación Infantil. El estudio afirma la importancia y el significado curricular de las materialidades dispuestas a los bebés en la organización del trabajo pedagógico.  
Palabras clave: niños, espacios, enseñanza.
Gestão democrática: experiências de práticas de gestores em escolas de educação básica
Authors: Bonez Juliane , Paulo dos santos Almir , Prsybyciem Moises Marques
Published: October 2023

O artigo tem o objetivo de analisar as experiências de práticas de gestão democrática em escolas de educação básica, desenvolvidas por gestores escolares. A abordagem metodológica utilizada na pesquisa foi a qualitativa, em relação ao objeto de estudo, sendo classificada como pesquisa de campo. Evidenciou-se a importância do papel da gestão escolar como mediadora. A participação do todo gera autonomia em cada sujeito, propiciando a tomada de decisão de forma coletiva. Esses resultados contribuem para estimular a democratização da educação para e pela democracia por meio de uma gestão democrática, bem como para repensar a formação de gestores escolares.
Palavras-chave: gestão democrática, democracia, experiências, comunidade escolar, gestão escolar.
 
Democratic management: experiences of management practices in basic education schools
ABSTRACT. The article aims to analyze the experiences of democratic management practices in basic education schools, developed by school managers. The methodological approach used in the research was qualitative and in relation to the object of study it was classified as field research. The importance of the role of school management as a mediator was highlighted. The participation of the whole generates autonomy in each subject, providing collective decision-making. These results contribute to encourage the democratization of education for and through democracy through democratic management, as well as to rethink the training of school managers.
Keywords: democratic management, democracy, experiences, school community, school management.
 
Gestión democrática: experiencias de prácticas gerenciales en escuelas de educación básica 
RESUMEN El artículo tiene como objetivo analizar las experiencias de prácticas de gestión democrática en escuelas de educación básica, desarrolladas por gestores escolares. El enfoque metodológico utilizado en la investigación fue cualitativo y en relación al objeto de estudio se catalogó como investigación de campo. Se destacó la importancia del papel de la dirección escolar como mediador. La participación del conjunto genera autonomía en cada sujeto, facilitando la toma de decisiones colectiva. Estos resultados contribuyen a incentivar la democratización de la educación para y por la democracia a través de la gestión democrática, así como a repensar la formación de directivos escolares.
Palabras clave: gestión democrática, democracia, experiencias, comunidad escolar, gestión escolar.
Precise Land Evaluation Implementation of the Regional Spatial Plan in the Sleman Regency to Maintain Human Health and Food Security
Authors: Wahyuti Isnaeni Sri , Zulaika Isti , Supriyadi Supriyadi , Tonabut Wasuthon
Published: October 2023

Agricultural land in Sleman Regency has changed many functions, including constructing toll roads and settlements. The conversion of agricultural land to non-agricultural land, without being balanced by the creation of new farmland, resulted in the threat of crisis. This research aims to adjust the spatial plan and its application in the field to suppress and control the rate of agricultural land conversion, thus supporting the maintenance and the realization of food security and good health. It was implemented in the Sleman Regency area covering 17 sub-districts. This research uses the institutional survey method, which collects secondary data from development policies and programs from relevant agencies via email, website or coming directly to the office. The results show that the total area of agricultural land conversion in Sleman Regency is 69.93 ha per year. Agricultural land needs to increase its size by 356 ha in 2019 to meet the demands of the applicable laws and regulations. Land use unrelated to the area's function can impact ecological imbalances and potential disasters. Efforts to optimize land use include land certification, granting, signage and tightening permits. Finally, this research study concluded that by optimizing land use, it is hoped that it will be able to maintain and realize food security and good health, especially in Sleman Regency.
Effectiveness of Media-Based Health Education on Stunting Prevention in Adolescents: A Systematic Review
Authors: Marlinawati Dwi Ayu , Rahfiludin Mohammad Zen , Mustofa Syamsulhuda Budi
Published: October 2023

Efforts to promote stunting prevention from an early age can be carried out by media that is effective at targeting youth, where youth activities cannot be separated from the digital world. This systematic review uses a scoping review approach and aims to identify media as an intervention in efforts to prevent stunting in adolescents. Article searches were conducted through Google Scholar, ScienceDirect, and PubMed published in 2018 to 2022 with criteria of full text, open access and keywords such as ‘media AND prevention AND stunting AND effective AND teen’ found 16,508 articles which were then obtained based on the inclusion criteria 8 selected papers. This research describes 5 media interventions for adolescent stunting prevention, including audiovisual; Android applications, social media, leaflets, and booklets. Social media is the most influential media in preventing stunting in adolescents with an increase in the pre-test and post-test difference by TikTok (36.75%), Instagram (22.29%), Twitter (20.25%), Youtube (16.66%), and Facebook (12.61%). Audiovisual videos accompanied by explanations are the second medium that is effectively used, marked by an increase in knowledge from 50.9% to 76.6% compared to the use of videos without reasons. The media interventions have proven effective in increasing adolescents understanding of stunting prevention. Information dissemination to the public, especially youth, is expected to utilize digital media to increase adolescents’ knowledge of stunting prevention which is more effective and efficient.