bluuebunny/crossref_metadata_2025 huggingface dataset:
A Novel Series of [1,2,4]Triazolo[4,3-a]Pyridine Sulfonamides as Potential Antimalarial Agents: In Silico Studies, Synthesis and In Vitro Evaluation
Authors: Karpina Veronika R. , Kovalenko Svitlana S. , Kovalenko Sergiy M. , Drushlyak Oleksandr G. , Bunyatyan Natalya D. , Georgiyants Victoriya A. , Ivanov Vladimir V. , Langer Thierry , Maes Louis
Published: September 2020

For the development of new and potent antimalarial drugs, we designed the virtual library with three points of randomization of novel [1,2,4]triazolo[4,3-a]pyridines bearing a sulfonamide fragment. The library of 1561 compounds has been investigated by both virtual screening and molecular docking methods using falcipain-2 as a target enzyme. 25 chosen hits were synthesized and evaluated for their antimalarial activity in vitro against Plasmodium falciparum. 3-Ethyl-N-(3-fluorobenzyl)-N-(4-methoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridine-6-sulfonamide and 2-(3-chlorobenzyl)-8-(piperidin-1-ylsulfonyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one showed in vitro good antimalarial activity with inhibitory concentration IC50 = 2.24 and 4.98 μM, respectively. This new series of compounds may serve as a starting point for future antimalarial drug discovery programs.
Superior Properties and Biomedical Applications of Microorganism-Derived Fluorescent Quantum Dots
Authors: Abdel-Salam Mohamed , Omran Basma , Whitehead Kathryn , Baek Kwang-Hyun
Published: September 2020

Quantum dots (QDs) are fluorescent nanocrystals with superb photo-physical properties. Applications of QDs have been exponentially increased during the past decade. They can be employed in several disciplines, including biological, optical, biomedical, engineering, and energy applications. This review highlights the structural composition and distinctive features of QDs, such as resistance to photo-bleaching, wide range of excitations, and size-dependent light emission features. Physical and chemical preparation of QDs have prominent downsides, including high costs, regeneration of hazardous byproducts, and use of external noxious chemicals for capping and stabilization purposes. To eliminate the demerits of these methods, an emphasis on the latest progress of microbial synthesis of QDs by bacteria, yeast, and fungi is introduced. Some of the biomedical applications of QDs are overviewed as well, such as tumor and microRNA detection, drug delivery, photodynamic therapy, and microbial labeling. Challenges facing the microbial fabrication of QDs are discussed with the future prospects to fully maximize the yield of QDs by elucidating the key enzymes intermediating the nucleation and growth of QDs. Exploration of the distribution and mode of action of QDs is required to promote their biomedical applications.
Cicer arietinum L. Sprouts’ Influence on Mineralization of Saos-2 and Migration of MCF-7 Cells
Authors: Zakłos-Szyda Małgorzata , Gałązka-Czarnecka Ilona , Grzelczyk Joanna , Budryn Grażyna
Published: September 2020

In the present study, we investigated the biological activity of four extracts obtained from Cicer arietinum L. sprouts. The fermentation of the sprouts with Lactobacillus casei and their incubation with β-glucosidase elevated the concentrations of isoflavonoids, especially coumestrol, formononetin and biochanin A. To study the biological activity of C. arietinum, the human osteosarcoma Saos-2 and human breast cancer MCF-7 cell lines were used. The extracts obtained from fermented sprouts exhibited the strongest ability to decrease intracellular oxidative stress in both types of cells. They augmented mineralization and alkaline phosphatase activity in Saos-2 cells, as well as diminished the secretion of interleukin-6 and tumor necrosis factor α. Simultaneously, the extracts, at the same doses, inhibited the migration of MCF-7 cells. On the other hand, elevated concentrations of C. arietinum induced apoptosis in estrogen-dependent MCF-7 cells, while lower doses stimulated cell proliferation. These results are important for carefully considering the use of fermented C. arietinum sprouts as a dietary supplement component for the prevention of osteoporosis.
Myrcene Attenuates Renal Inflammation and Oxidative Stress in the Adrenalectomized Rat Model
Authors: Islam Azim Ullah Shamsul , Hellman Björn , Nyberg Fred , Amir Naheed , Jayaraj Richard L. , Petroianu Georg , Adem Abdu
Published: September 2020

Physiological Glucocorticoids are important regulators of the immune system. Pharmacological GCs are in widespread use to treat inflammatory diseases. Adrenalectomy (ADX) has been shown to exacerbate renal injury through inflammation and oxidative stress that results in renal impairment due to depletion of GCs. In this study, the effect of myrcene to attenuate renal inflammation and oxidative stress was evaluated in the adrenalectomized rat model. Rats were adrenalectomized bilaterally or the adrenals were not removed after surgery (sham). Myrcene (50 mg/kg body weight, orally) was administered post ADX. Myrcene treatment resulted in significant downregulation of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) compared to untreated ADX rats. In addition, myrcene resulted in significant downregulation of immunomodulatory factors (IFNγ and NF-κB) and anti-inflammatory markers (IL-4 and IL-10) in treated ADX compared to untreated ADX. Myrcene significantly increased the antioxidant molecules (CAT, GSH, and SOD) and decreased MDA levels in treated ADX compared to untreated. Moreover, myrcene treatment reduced the expression of COX-2, iNOS, KIM-1, and kidney functional molecules (UREA, LDH, total protein, and creatinine) in ADX treated compared to ADX untreated. These results suggest that myrcene could be further developed as a therapeutic drug for treatment of kidney inflammation and injury.
Versatility of the Cyano Group in Intermolecular Interactions
Authors: Scheiner Steve
Published: September 2020

Several cyano groups are added to an alkane, alkene, and alkyne group so as to construct a Lewis acid molecule with a positive region of electrostatic potential in the area adjoining these substituents. Although each individual cyano group produces only a weak π-hole, when two or more such groups are properly situated, they can pool their π-holes into one much more intense positive region that is located midway between them. A NH3 base is attracted to this site, where it forms a strong noncovalent bond to the Lewis acid, amounting to as much as 13.6 kcal/mol. The precise nature of the bonding varies a bit from one complex to the next but typically contains a tetrel bond to the C atoms of the cyano groups or the C atoms of the linkage connecting the C≡N substituents. The placement of the cyano groups on a cyclic system like cyclopropane or cyclobutane has a mild weakening effect upon the binding. Although F is comparable to C≡N in terms of electron-withdrawing power, the replacement of cyano by F substituents substantially weakens the binding with NH3.
ST09, A Novel Curcumin Derivative, Blocks Cell Migration by Inhibiting Matrix Metalloproteases in Breast Cancer Cells and Inhibits Tumor Progression in EAC Mouse Tumor Models
Authors: Nirgude Snehal , Mahadeva Raghunandan , Koroth Jinsha , Kumar Sujeet , Kumar Kothanahally S. Sharath , Gopalakrishnan Vidya , S Karki Subhas , Choudhary Bibha
Published: September 2020

Purpose: Curcumin is known for its anticancer and migrastatic activity in various cancers, including breast cancer. Newer curcumin derivatives are being explored to overcome limitations of curcumin like low bioavailability, stability, and side effects due to its higher dose. In this study, the synthesis of ST09, a novel curcumin derivative, and its antiproliferative, cytotoxic, and migrastatic properties have been explored both in vitro and in vivo. Methods: After ST09 synthesis, anticancer activity was studied by performing standard cytotoxicity assays namely, lactate dehydrogenase (LDH) release assay, 3-(4, 5-dimethylthiazol-2-yl)-2–5-diphenyletrazolium bromide (MTT), and trypan blue exclusion assay. Annexin-FITC, cell cycle analysis using flow cytometry, and Western blotting were performed to elucidate cell death mechanisms. The effect on the inhibition of cell migration was studied by transwell migration assay. An EAC (Ehrlich Ascites carcinoma) induced mouse tumor model was used to study the effect of ST09 on tumor regression. Drug toxicity was measured using aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), and flow-cytometry based lymphocyte count. Histological analysis was performed for assessment of any tissue injury post ST09 treatment. Results: ST09 shows an approximate 100-fold higher potency than curcumin, its parent compound, on breast tumor cell lines MCF-7 and MDA-MB231. ST09 arrests the cell cycle in a cell type-specific manner and induces an intrinsic apoptotic pathway both in vitro and in vivo. ST09 inhibits migration by downregulating matrix metalloprotease 1,2 (MMP1,2) and Vimentin. In vivo, ST09 administration led to decreased tumor volume in a mouse allograft model by boosting immunity with no significant drug toxicity. Conclusion: ST09 exhibits antiproliferative and cytotoxic activity at nanomolar concentrations. It induces cell death by activation of the intrinsic pathway of apoptosis both in vitro and in vivo. It also inhibits migration and invasion. This study provides evidence that ST09 can potentially be developed as a novel antitumor drug candidate for highly metastatic and aggressive breast cancer.
Effects of Two Kinds of Iron Nanoparticles as Reactive Oxygen Species Inducer and Scavenger on the Transcriptomic Profiles of Two Human Leukemia Cells with Different Stemness
Authors: Luo Tao , Gao Jinliang , Lin Na , Wang Jinke
Published: September 2020

Leukemia is a common and lethal disease. In recent years, iron-based nanomedicines have been developed as a new ferroptosis inducer to leukemia. However, the cytotoxicity of iron nanoparticles to leukemia cells at the transcriptomic level remains unclear. This study investigated the effects of two kinds of iron nanoparticles, 2,3-Dimercaptosuccinic acid (DMSA)-coated Fe3O4 nanoparticles (FeNPs) as a reactive oxygen species (ROS) inducer and Prussian blue nanoparticles (PBNPs) as an ROS scavenger, on the transcriptomic profiles of two leukemia cells (KG1a and HL60) by RNA-Seq. As a result, 470 and 1690 differentially expressed genes (DEGs) were identified in the FeNP-treated HL60 and KG1a cells, respectively, and 2008 and 2504 DEGs were found in the PBNP-treated HL60 and KG1a cells, respectively. Among them, 14 common upregulated and 4 common downregulated DEGs were found, these genes were representative genes that play key roles in lipid metabolism (GBA and ABCA1), iron metabolism (FTL, DNM1, and TRFC), antioxidation (NQO1, GCLM, and SLC7A11), vesicle traffic (MCTP2, DNM1, STX3, and BIN2), and innate immune response (TLR6, ADGRG3, and DDX24). The gene ontology revealed that the mineral absorption pathway was significantly regulated by PBNPs in two cells, whereas the lipid metabolism and HIF-1 signaling pathways were significantly regulated by FeNPs in two cells. This study established the gene signatures of two kinds of nanoparticles in two leukemia cells, which revealed the main biological processes regulated by the two kinds of iron nanoparticles. These data shed new insights into the cytotoxicity of iron nanoparticles that differently regulate ROS in leukemia cells with variant stemness.
Importance of Dietary Phosphorus for Bone Metabolism and Healthy Aging
Authors: Serna Juan , Bergwitz Clemens
Published: September 2020

Inorganic phosphate (Pi) plays a critical function in many tissues of the body: for example, as part of the hydroxyapatite in the skeleton and as a substrate for ATP synthesis. Pi is the main source of dietary phosphorus. Reduced bioavailability of Pi or excessive losses in the urine causes rickets and osteomalacia. While critical for health in normal amounts, dietary phosphorus is plentiful in the Western diet and is often added to foods as a preservative. This abundance of phosphorus may reduce longevity due to metabolic changes and tissue calcifications. In this review, we examine how dietary phosphorus is absorbed in the gut, current knowledge about Pi sensing, and endocrine regulation of Pi levels. Moreover, we also examine the roles of Pi in different tissues, the consequences of low and high dietary phosphorus in these tissues, and the implications for healthy aging.
The Relevance of Selenium Status in Rheumatoid Arthritis
Authors: Turrubiates-Hernández Francisco Javier , Márquez-Sandoval Yolanda Fabiola , González-Estevez Guillermo , Reyes-Castillo Zyanya , Muñoz-Valle José Francisco
Published: September 2020

Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease that can cause joint damage. Among the environmental risk factors, diet plays an important role because it can aggravate or attenuate inflammation. Selenium (Se) is considered an essential trace element since it is a structural component of antioxidant enzymes; however, its concentration can be affected by diet, drugs and genetic polymorphisms. Studies have reported that RA patients have a deficient diet in some food groups that is associated with parameters of disease activity. Furthermore, it has been shown that there is an alteration in serum Se levels in this population. Although some clinical trials have been conducted in the past to analyze the effect of Se supplementation in RA, no significant results were obtained. Contrastingly, experimental studies that have evaluated the effect of novel Se nanoparticles in RA-induced models have shown promising results on the restoration of antioxidant enzyme levels. In particular, glutathione peroxidase (GPx) is an important selenoprotein that could have a modulating effect on inflammation in RA. Considering that RA patients present an inflammatory and oxidative state, the aim of this review is to give an overview of the current knowledge about the relevance of Se status in RA.
Microscopic Structure from Motion (SfM) for Microscale 3D Surface Reconstruction
Authors: Um Dugan , Lee Sangsoo
Published: September 2020

In microscale photogrammetry, the confocal microscopic imaging technique has been the dominant trend. Unlike the confocal imaging mostly for transparent objects, we propose a novel method to construct a 3D shape in microscale for various micro-sized solid objects in a broad spectrµm of applications. Recently, the structure from motion (SfM) demonstrated reliable 3D reconstruction capability for macroscale objects. In this paper, we discuss the results of a novel micro-surface reconstruction method using the Structure from Motion in microscale. The proposed micro SfM technique utilizes the photometric stereovision via microscopic photogrammetry. The main challenges lie in the scanning methodology, ambient light control, and light conditioning for microscale object photography. Experimental results of the microscale SfM, as well as the modeling accuracy analysis of a reconstructed micro-object, are shared in the paper.
Biosensors Based on Mechanical and Electrical Detection Techniques
Authors: Chalklen Thomas , Jing Qingshen , Kar-Narayan Sohini
Published: September 2020

Biosensors are powerful analytical tools for biology and biomedicine, with applications ranging from drug discovery to medical diagnostics, food safety, and agricultural and environmental monitoring. Typically, biological recognition receptors, such as enzymes, antibodies, and nucleic acids, are immobilized on a surface, and used to interact with one or more specific analytes to produce a physical or chemical change, which can be captured and converted to an optical or electrical signal by a transducer. However, many existing biosensing methods rely on chemical, electrochemical and optical methods of identification and detection of specific targets, and are often: complex, expensive, time consuming, suffer from a lack of portability, or may require centralised testing by qualified personnel. Given the general dependence of most optical and electrochemical techniques on labelling molecules, this review will instead focus on mechanical and electrical detection techniques that can provide information on a broad range of species without the requirement of labelling. These techniques are often able to provide data in real time, with good temporal sensitivity. This review will cover the advances in the development of mechanical and electrical biosensors, highlighting the challenges and opportunities therein.
Management of Anterocapitis and Anterocollis: A Novel Ultrasound Guided Approach Combined with Electromyography for Botulinum Toxin Injection of Longus Colli and Longus Capitis
Authors: Farrell Michael , Karp Barbara I. , Kassavetis Panagiotis , Berrigan William , Yonter Simge , Ehrlich Debra , Alter Katharine E.
Published: September 2020

Chemodenervation of cervical musculature using botulinum neurotoxin (BoNT) is established as the gold standard or treatment of choice for management of Cervical Dystonia (CD). The success of BoNT procedures is measured by improved symptomology while minimizing side effects and is dependent upon many factors including: clinical pattern recognition, identifying contributory muscles, BoNT dosage, and locating and safely injecting target muscles. In patients with CD, treatment of anterocollis (forward flexion of the neck) and anterocaput (anterocapitis) (forward flexion of the head) are inarguably challenging. The longus Colli (LoCol) and longus capitis (LoCap) muscles, two deep cervical spine and head flexor muscles, frequently contribute to these patterns. Localizing and safely injecting these muscles is particularly challenging owing to their deep location and the complex regional anatomy which includes critical neurovascular and other structures. Ultrasound (US) guidance provides direct visualization of the LoCol, LoCap, other cervical muscles and adjacent structures reducing the risks and side effects while improving the clinical outcome of BoNT for these conditions. The addition of electromyography (EMG) provides confirmation of muscle activity within the target muscle. Within this manuscript, we present a technical description of a novel US guided approach (combined with EMG) for BoNT injection into the LoCol and LoCap muscles for the management of anterocollis and anterocaput in patients with CD.
Stormwater Filtration Performance for the Ecosol Storm Pit (Class 2): Statistical Analysis of Field Data
Authors: Pooya Nejad Fereydoon , Zecchin Aaron C.
Published: September 2020

An independent field performance evaluation for a secondary stormwater filtration device, named the Ecosol Strom Pit (Class 2), was performed between May 2017 and July 2019 in an urban catchment in Queensland, Australia. During the testing period, a total of 37 rainfall events were recorded, of which between 15 and 21 events were evaluated as qualifying for the purposes of characterizing the removal efficiency performance of the device. A statistical analysis of the event mean concentrations (EMCs) of the flow streams through the device indicate a statistically significant difference between the influent and effluent streams. A variety of pollutant removal evaluation metrics, including concentration-based and total load-based metrics, were utilized in this study to characterise the efficacy of the device. Two new approaches are proposed for facilitation the analysis: a nonlinear regression approach to more effectively deal with nonlinear patterns in the influent and effluent data and the regression of concentration (ROC), which is an added concentration-based metrics. In summary, the removal efficiencies of the Ecosol Storm Pit (Class 2) were evaluated to be 72–74% for total suspended solids (TSS), 45–50% for total phosphorus (TP), 41–45% for total nitrogen (TN), 27–32% for total heavy metals (THM), 79–85% for total petroleum hydrocarbons (TPH), and 80–88% for total recoverable hydrocarbons (TRH).
Applicability of Benthic Diatom Indices Combined with Water Quality Valuation for Dish Lake from Nanjishan Nature Reserve, Lake Poyang
Authors: Yang Junfei , Ji Yong , Yan Ruyu , Liu Xingchen , Zhang Jie , Wu Naichen , Wang Kai
Published: September 2020

Benthic diatom indices developed in the Europe Union have been widely accepted as indicators of the trophic state and water quality in freshwater ecosystems. In China, most of the benthic diatom-based indices have not been widely tested or evaluated before. For this purpose, the water quality parameters and benthic diatoms community structures at 20 sample sites in the dish lake of Nanjishan Nature Reserve in Poyang Lake were investigated in this study and 18 widely-applied diatom indices were established. The statistical results indicated that most water quality parameters including Total Nitrogen (TN), Total Phosphorus (TP), ammonia nitrogen (NH4+), Chemical Oxygen Demand (COD) and Chlorophyll (Chl) were highly correlated with each other at a confidence level of 0.05. Water quality sampling sites from 8 lakes could be classified into 4 groups based on the integrated comprehensive scores using principal components analysis (PCA). Monitoring sites could also be divided into 4 groups based on clustering analysis with hierarchical methods for diatom dominant species in 20 sampling sites. According to the status of water ecological health recognition and box plot analysis in different water quality groups and diatom dominant species groups, only 3 diatom indices including the Biological Diatom Index (IBD), Specific Pollution Sensitivity Index (IPS) and Louis Leclercq Diatom Index (IDSE) demonstrated good evaluation suitability and good correlation within different water quality grades at the final stage. The above results revealed that IBD, IPS and IDSE were the most suitable diatom indices for the water quality evaluation of the dish lake in the Nanjishan Nature Reserve, Lake Poyang.
Assessing the Climate Tendency over the Yangtze River Delta, China: Properties, Dry/Wet Event Frequencies, and Causes
Authors: Wu Yanfei , Xu Yu
Published: September 2020

In view of the important role to in revealing climate wet/dry tendency, Standardized Precipitation Index (SPI) was applied to identify wetness/dryness trends and their relationship with large-scale climate oscillations in the Yangtze River Delta (YRD) from 1957 to 2016. The daily precipitation in 43 meteorological stations was used to calculate SPI time series for a time scale of 12 months. The results indicate that there are three dominant geographic sub-regions of SPI-12 modes. Increasing trends dominate, except for some of the northern regions. High frequencies of wet and dry events are mainly located in the southern regions and part of the northwestern and southeastern regions, respectively. Temporally, large-scale dry events mainly happened in the 1960s–1970s, and wet events in the 1990s and the 2010s. They show a tendency towards more wet conditions of the regional climate in the YRD. The climate variations are primarily controlled by large-scale atmospheric oscillations. The North Atlantic Oscillation (NAO) and Southern Oscillation Index (SOI) have much higher influence on the variation of SPI in the mid and east; whereas the Pacific Decadal Oscillation (PDO) and North Pacific Index (NP) show higher correlations with SPI in the northern regions of the YRD.
Rational antibiotic prescribing in primary care: qualitative study of opportunities and obstacles
Authors: Sundvall Pär-Daniel , Skoglund Ingmarie , Hess-Wargbaner Maria , Åhrén Christina
Published: September 2020

Background

The Swedish strategic programme against antibiotic resistance (Strama) has worked towards rational use of antibiotics, and Swedish antibiotic prescribing is low.

Aim

To explore how opportunities and obstacles for rational antibiotic prescribing were perceived by primary health care centres (PHCCs).

Design & setting

A qualitative study of 50 randomly selected reports from approximately 200 PHCCs in 2013 and 2016 in Region Västra Götaland, Sweden.

Method

One assigned GP at each PHCC reported yearly in an open-ended questionnaire on how the PHCC worked to improve antibiotic prescribing. The report included several antibiotic-related tasks and a summary of reflective meetings with the doctors, the head of the PHCC, and, preferably, also the nurses. The reports were qualitatively analysed using Malterud’s systematic text condensation (STC).

Results

'Everyone wants to do right, but sometimes you do not know what's right or wrong.' Knowledge about diagnosis and treatment of infectious diseases was highlighted. Knowledge and skills had to be internalised by the clinician in order to bring about behavioural change. This could be achieved through reflective, collegial dialogues where consensus often was found. Structural factors at the PHCC could provide good conditions for 'doing right', but could also constitute obstacles. Teamwork involving all personnel was important to achieve rational antibiotic prescribing.

Conclusion

Enablers for rational antibiotic prescribing were knowledge, reflective collegial dialogues, a well organised workplace, and a collaborating team. Obstacles were lack of knowledge, insufficient staffing, perceived lack of time, and overuse of laboratory tests. Patients’ attitudes and expectations could be both.
A 4G LTE Evolved packet Core Planning and Deployment in Freetown Sierra Leone
Authors: Koroma Mohamed , Sawaneh Ibrahim Abdulai
Published: September 2020

Wireless broadband subscribers have tripled in the past two decades in the world. It subsequently adds more burden on the network traffic, thereby pressuring the current 2G / 3G wireless network infrastructural development in Freetown, Sierra Leone. The existing 2G / 3G network infrastructures in Freetown offer limited resources for download and upload speed of 12.54Mbps and 2.59Mbps, respectively, to active subscribers. The exponential increase in the country’s population has adverse effects on the subscriber’s database. Therefore, a considerable task is faced by the country’s telecommunication network infrastructures to devise an improvement and efficient technologies to augment the current system to handle the numerous issues. Three active private mobile network operators (X, Y, & Z) and one Government-owned operator (W) exist in the country. The only operator that runs across the country is operator X, and it has the highest number of subscribers. The country has just rollout it Long Term Evolution (LTE) by the private MNOs.

The research is to encourage the Sierra Leone National Telecommunication Commission (NATCOM), a telecommunication regulatory body, to mandate all MNOs in the country to roll out the 4G LTE core network infrastructure in Freetown. ARIMA model is used to analyze the throughputs (kbps) prediction to ascertain 4G LTE rollout using the Python programming language is an effective alternative. Statistical data from operator X for ten years for Freetown municipality from January 2010 - November 2019 was collected. The research concludes that 4G LTE deployment or upgrade was necessary for the Freetown municipality.
Assessing Resilience in Youth (U16) Volleyball National Teams
Authors: Patsiaouras Asterios , Stirbu Catalin
Published: September 2020

The objective of this study was to investigate the resilience of youth high level volleyball players. Forty-eight volleyball national team players U16 from Greece and Romania participated to the study (18 females and 30 males). The Self Evaluation Resilience test was used for the study. The data were analyzed with SPSS 21.0 using one-way ANOVA with post hoc Bonferroni adjustment test. Results showed statistically significant differences between the males and females national team volleyball players in variables ‘‘healthy lifestyle’’ and ‘‘self-efficacy’’. It was concluded that coaches and volleyball players should recognize that female’s volleyball players focused more in healthy life style and having less self-efficacy comparing to same aged male’s volleyball players.
Rhetoric in Purananuru
Authors: S Suja
Published: September 2020

The word has a history; The words by nature are telling history because the nature of the word and its mechanism of action are inherent in the nature of change. These changes have been periodically taken into preferred action beyond the memory of time and society. These changes involve the development of the language itself. The grandiloquence research on the glossary of diction or phraseology that has been taking place since the last century has set the stage for the endorsing of the myth and uniqueness of Tamil in the order of world languages. This article elucidates the linguistic richness of the epistles and the villanelle compositions based on the tenuous words found in the Purananuru, alone, one of the oldest literary works in Tamil.
ANALISA SIMULASI MONTE CARLO DALAM MENENTUKAN PENDAPATAN PENJUALAN KERIPIK MACO BADARAI ISTIQOMAH PADANG SUMATERA BARAT
Authors: Hafizh Muhammad , Gema Rima Liana
Published: September 2020

Desain sistem ini menentukan jumlah penjualan barang-barang dengan menggunakan metode monte carlo di industri rumahan Istiqomah bertujuan untuk memprediksi penjualan setiap produk untuk bulan berikutnya dan mencari pendapatan kotor di setiap barang yang dijual. Sistem dirancang untuk memprediksi barang dan mencari keuntungan kotor di setiap jenis barang di toko yang dibuat menggunakan PHP dan MySQL sebagai databasenya. Dengan sistem ini dapat digunakan oleh industri rumahan untuk mensimulasikan penjualan barang di toko, dan dapat memudahkan pemilik industri rumahan untuk mendapatkan informasi tentang kemungkinan yang akan terjadi pada penjualan produk keripik maco.
SISTEM PENDUKUNG KEPUTUSAN MENGGUNAKAN METODE WEIGHTED PRODUCT UNTUK PENENTUAN PRIORITAS PEMBANGUNAN JALAN UMUM DI DESA PEGAGAN JULU VII
Authors: Lingga Duy Murdy , Marbun Murni
Published: September 2020

Terbatasnya bantuan dana dari pemerintah untuk perbaikan fasilitas pembangunan jalan umum di desa-desa, maka pemerintah desa sebagai penyelenggara pembangunan jalan mempunyai kewajiban untuk memprioritaskan pembangunan jalan secara berkala dalam rangka mempertahankan tingkat pelayanan jalan sesuai dengan standar pelayanan minimal yang ditetapkan.Penelitian ini bertujuan untuk membuat System Pendukung Keputusan (SPK) untuk membantu pemerintah desa untuk menentukan prioritas pembangunan jalan umum di desa Pagagan Julu VII. Kriteria prioritas pembangunan jalan umum adalah kondisi jalan, jumlah penduduk, jarak terhadap pusat perekonomian, Jarak terhadap pusat pendidikan dan panjang jalan yang akan diperbaiki.Sistem dibangun dengan bahasa pemrograman Visual Bacic 2010 dan menerapkan metode Weighted Product (WP) untuk menentukan prioritas pembangunan jalan umum.Hasil dari penelitian adalah sebuah sistem pendukung keputusan yang dapat menentukan prioritas pembangunan jalan umum. Implementasi sistem menunjukkan dari delapan (8) dusun yang terdapat pada desa Pagagan Julu VII, jalan umum di DesaTanggiang merupakan prioritas pembangunan jalan umum.
OPTIMALISASI CLOUD STORAGE UNTUK AKSESBILITAS DATA IMAGE PADA MOBILE APPS DI STMIK AMIK RIAU
Authors: Nasution Torkis
Published: September 2020

Dalam meningkatkan aksesibilitas terhadap data, perlu mempertimbangkan media penyimpanan cloud storage. Aplikasi dapat mengakses data menjadi informasi sehingga user dapat menggunakan secara optimal. Pada saat ini belum tersedia media penyimpanan data resmi. Sulit mengidentifikasi historis sebuah foto secara detail. Foto aktivitasi telah ada di setiap kegiatan, namun pada saat dibutuhkan tidak tersedia dan belum ada aplikasi foto capture yang terintegrasi dengan agenda. Walaupun setiap kegiatan tersedia dokumentasi, namun tidak dikelola berbasis teknologi. Cloud storage sudah menjadi trend dalam pengelolaan data, namun belum dimanfaatkan secara optimal. Penelitian ini menyediakan aplikasi yang dapat digunakan untuk meng-capture foto secara otomatis upload ke cloud storage. Perangkat smartphone berbasis Android, secara umum terjangkau dan umum digunakan. Setiap foto yang di upload dilengkapi dengan informasi waktu, koordinat, momentum, dan lokasi. Aplikasi telah dilakukan uji black box dengan akurasi kehandalan 76.5%.
POLA FREKUENSI PENJUALAN BARANG BALI MART MENGGUNAKAN FP-GROWTH
Authors: Putri Dewi Eka
Published: September 2020

Tingginya persaingan dalam bisnis, terutama dalam industri minimarket, membuat para pengelola minimarket harus memikirkan cara agar dapat meningkatkan penjualan di minimarket mereka. Salah satunya  bisa dilakukan dengan memanfaatkan data transaksi di minimarket tersebut. Bali Mart merupakan salah satu minimarket yang berada di Padang. Masalah di Bali Mart adalah banyaknya barang yang tidak terjual karena pihak minimarket tidak bisa melihat pola beli konsumen. Pola beli konsumen diperlukan agar pihak minimarket bisa melihat frekuensi barang yang dibeli konsumen dan mengelola tata letak barang di minimarket tersebut, sehingga akan sangat memudahkan konsumen dalam mencari barang saat berbelanja. Data mining merupakan pendekatan yang dinilai cocok untuk mendapatkan pola frekuensi barang di Bali Mart. Penelitian ini menggunakan 12 transaksi penjualan di Bali Mart. Contoh pola penjualan barang yang diperoleh adalah dari 12 transaksi yang membeli GR, 6 transaksi membeli ST. Algoritma yang digunakan adalah FP-Growth dapat memecahkan masalah pihak minimarket dalam melihat kecenderungan barang yang dibeli secara bersamaan oleh konsumen, sehingga akan memudahkan pihak pengelola minimarket dalam mengatur pengadaan barang yang akan dijual dan mengatu tata letak barang di minimarket agar memudahkan konsumen dalam mencari barang.
RANCANG BANGUN SISTEM INFORMASI POS (POINT OF SALE) UNTUK KASIR MENGGUNAKAN KONSEP BAHASA PEMROGRAMAN ORIENTASI OBJEK
Authors: Siddik Muhammad , Samsir Samsir
Published: September 2020

Kafe Filoscoffee merupakan tempat usaha di bidang kuliner yang banyak diminati oleh pengunjung. Kafe ini memiliki kendala dalam sistem transaksi penjulan dan pengolahan data rekapitulasi laporan transaksi penjulan dikarenakan belum memanfaatkan sistem aplikasi Point of Sales (POS). Peran kasir yang masih cukup sederhana seperti proses penjumlahan dan pengurangan transaksi masih menggunakan kalkulator yang mana tidak dikerjakan secara otomatis dan sering menghambat transaksi penjualan. POS yang dirancang dan dibagun bertujuan mencatat transaksi penjualan dan mengolahan data stok barang sehingga membantu meningkatkan kinerja kegiatan operasional dan mempercepat proses pelayanan. Sistem informasi POS dibangun menggunakan bahasa Pemrograman Orientasi Objek (OOP) sistem ini mampu mengolah semua data transaksi penjualan. Proses penjumlahan dan pengurangan dapat dilakukan lebih cepat, tepat dan akurat sehingga terhindar dari resiko kesalahan dalam perhitungan keuangan serta pendataan stok barang, Sistem ini juga dapat melakukan proses pencarian data, penyimpanan data, pengelompokkan data sehingga dalam pembuatan laporan dapat berberjalan dengan efektif dan efisien.
Introduction
Authors: Brown Nathan , Arjomand Saïd Amir
Published: September 2020

The understanding of law in the Middle East requires not simply different disciplinary perspectives but bringing disciplines into dialogue with each other. It also requires analysis that crosses historical periods in order to understand legal systems as ones that develop over time based on longstanding traditions and earlier transformations, not simply European intrusion. We present a series of analyses by scholar who, while anchored in their own discipline, historical focus, and geographical specialization consciously work to address a broad social scientific audience.
Метафізика Декарта як вчення про умови саморозбудови особистості
Authors: Malivskyi Anatoly
Published: September 2020

Опонуючи дискусійній рецепції метафізики Декарта, автор зосереджується на її тлумаченні як умов особистісної самореалізації. Інтерпретація мислителя в контексті незавершеної революції Коперника прояснює чинники актуалізації належних засадин людської поведінки. У процесі звернення до приватного листування обґрунтовується правомірність а) оцінки періоду роботи над незавершеними «Правилами для керування розумом» як етапу метафізики та б) з’ясування мотивів роботи над незавершеним ним текстом. Аналіз спадщини Декарта як осмислення умов розбудови особистості увиразнює її змістовну спорідненість із вченням Канта. Йдеться насамперед про межі людського знання як передумову свободи, а також про принципову відмінність знань людини та зовнішніх речей. Глибоке знайомство з метафізикою Декарта свідчить про її дистанціювання від науки та релігії та його розважливе ставлення до ідеї абсолютизації мислення. А оскільки усвідомлення метафізичності людської природи зумовлює звертання Декарта до мистецтва, то подальші перспективи дослідження автор пов’язує з вивченням його ролі.
Національні філософські традиції як джерело пам’яті і примирення: на матеріалі українофільського дискурсу ХІХ ст.
Authors: Volkovskyi Volodymyr
Published: September 2020

У статті фокусується увага на проблематиці національної ідентичності, аналізуючи проблеми конструювання історичної пам’яті, пов’язані з ними ситуації забуття, пам’яті, примирення і ворожнечі, конструювання політичного та історичного суб’єктів. Звертаючись до українофільського дискурсу ХІХ століття, автор показує, як конструюється ідеальний суб’єкт, його умоглядний простір і час, і як це може допомогти у розв’язанні актуальних питань сучасної політики, зокрема дебатах довкола історичної пам’яті, національної ідеї, суспільної єдності та діалогу тощо.
ANALISIS KINERJA KEUANGAN PADA SWALAYAN SUMBER MAKMUR KOTA KUPANG
Authors: Kerihi Anthon Simon Yohanis
Published: September 2020

Penelitian ini bertujuan untuk menganalisis perkembangan kinerja keuangan di Swalayan Sumber Makmur dari tahun 2013-2017. Analisis peningkatan kinerja keuangan diukur dengan menggunakan analisis Ratio Financial Statement untuk mengetahui pencapaian keuangan perusahaan. Jenis rasio yang digunakan adalah Rasio Likuiditas, Rasio Solvabilitas, Rasio Aktivitas, dan Rasio Profitabilitas. Hasil penelitian menunjukkan bahwa kinerja keuangan dengan perhitungan analisis dengan Rasio Likuiditas memiliki kinerja yang buruk diukur dengan Rasio Lancar dengan rata-rata 174%, Rasio Cepat dengan rata-rata 70%, Rasio Kas dengan rata-rata 70%. Rasio Solvabilitas memiliki kinerja yang baik diukur dengan Debt to Equity Ratio dengan rata-rata 99% dan Times Earned Ratio dengan rata-rata 354%. Rasio Aktivitas memiliki kinerja yang buruk diukur dengan Perputaran Persediaan 1,4 kali dan Rata-rata Persediaan 288 hari. Rasio Profitabilitas memiliki kinerja yang baik diukur dengan ROA dengan rata-rata 14% dan ROE dengan rata-rata 14%. Hasil penelitian ini digunakan untuk mempertahankan manajer sumber daya dan meningkatkan kemampuan perusahaan untuk menghasilkan laba. Selain itu, dapat juga digunakan sebagai fungsi kontrol dalam evaluasi implementasi program di supermarket sehingga semua perbedaan yang tidak menguntungkan perusahaan dapat lebih cepat diatasi.

Kata kunci: Rasio Likuiditas, Rasio Solvabilitas, Rasio Aktivitas, dan Rasio Profitabilitas.

 

This study aims to analyze the development of financial performance at Sumber Makmur Supermaket from year 2013-2017. The development of financial performance analysis is measured by using Ratio Financial Statement analysis to know the company’s financial achievement. The type of ratio used Liquidity Ratio, Solvability Ratio, Activity Ratio, and Profitability Ratio. The results showed that the financial performance with the calculation of analysis with Liquidity Ratio has a poor performance measured by Current Ratio with an average of 174%, Quick Ratio with an average of 70%, Cash Ratio with an average of 70%. Solvency Ratio has a good performance measured by Debt to Equity Ratio with an average of 99% and Times Earned Ratio with an average of 354%. The Activity Ratio has a poor performance measured by Inventory Turnover of 1.4 times and an Inventory Average of 288 days. Profitability ratios have good performance measured by ROA with an average of 14% and ROE with an average of 14%. The results of this study are used to maintain resource managers and improve the company's ability to generate profits. In addition, it can also be used as a control function in the evaluation of the implementation of the program in supermarkets so that all differences that are not profitable companies can be more quickly overcome.

Keywords: Liquidity Ratio, Solvability Ratio, Activity Ratio, and Profitability Ratio.
KEMUNGKINAN PENERAPAN SISTEM JUST IN TIME PRODUKSI PADA HOME INDUSTRY “IXXES” KUPANG
Authors: Balich Ali Hardin , Mutia Karmila Dwi Lestari
Published: September 2020

Tujuan dari penelitian ini adalah untuk menentukan apakah sistem Just In Time dapat diterapkan di Home Industry "IXXES", sebuah UMKM yang bergerak di industri makanan. Penelitian ini berfokus pada bagian produksi yang sesuai dengan persyaratan penerapan Sistem produksi Just In Time, yaitu (1) organisasi pabrik, (2) pelatihan tim atau keterampilan, (3) pembentukan alur atau penyederhanaan, (4) kanban pull system, (5) visibilitas visual atau kontrol, (6) eliminasi bottleneck , (7) ukuran lot dan pengaturan waktu pengukuran, (8) total pemeliharaan produktif, (9) kemampuan untuk memproses dan perbaikan berkelanjutan, dan (10) pemasok. Metode pengumpulan data yang digunakan dalam penelitian ini adalah wawancara, observasi dan dokumentasi. Teknik analisis data yang digunakan adalah analisis komparatif, yaitu suatu metode yang digunakan untuk membandingkan objek penelitian dengan teori sebagai konseppembanding. Hasil penelitian ini adalah bahwa sistem produksi Just In Time dimungkinkan untuk Home Industry "IXXES" karena ada tiga kondisi yang belum terpenuhi dan dapat dipenuhi dimasa depan.
KEMUNGKINAN PENERAPAN SISTEM JUST IN TIME PRODUKSI PADA HOME INDUSTRY “IXXES” KUPANG
Authors: Balich Ali Hardin , Mutia Karmila Dwi Lestari
Published: September 2020

Tujuan penelitian ini adalah untuk mengetahui apakah sistem Just In Time mungkin untuk diterapkan pada Home Industry “IXXES" yakni sebuah UMKM yang bergerak dibidang industri makanan. Penelitian ini berfokus pada bagian produksi yang sesuai dengan syarat penerapan sistem Just In Time produksi, yaitu (1) organisasi pabrik, (2) pelatihan atau tim atau keterampilan, (3) membentuk aliran atau penyederhanaan, (4) kanban pull sistem, (5) visilibilitas atau pengendalian visual, (6) eliminasi kemacetan (bottleneck), (7) ukurun lot dan pengukuran waktu set up, (8) total productive maintenance, (9) kemampuan proses dan perbaikan berkesinambungan, serta (10) pemasok. Metode pengumpulan data yang digunakan dalam penelitian ini yaitu wawancara, observasi, dan dokumentasi. Teknik analisis data yang digunakan adalah analisis komparatif yaitu suatu cara yang digunakan untuk membandingkan objek penelitian dengan teori sebagai konsep pembanding. Hasil dari penelitian ini menunjukan bahwa sistem Just In Time produksi mungkin diterapkan pada Home Industry “IXXES" karena terdapat tiga syarat yang belum dipenuhi akan tetapi dapat dipenuhi dimasa yang akan datang.

Kata Kunci : Sistem Just In Time produksi
PENGARUH AKUNTABILITAS DAN TRANSPARANSI TERHADAP PENGELOLAAN ALOKASI DANA DESA (ADD) DALAM PENCAPAIAN GOOD GOVERNANCE PADA DESA MANULEA, KECAMATAN SASITAMEAN, KABUPATEN MALAKA
Authors: Garung Christina Yunnita , Ga Linda Lomi
Published: September 2020

Penelitian ini bertujuan untuk mengetahui pengaruh akuntabilitas dan transparansi terhadap pengelolaan alokasi dana desa dan menginginkan tata kelola yang baik di Desa Manulea, Kecamatan Sasitamean, Kabupaten Malaka. Dalam penelitian ini, jenis penelitian yang digunakan oleh peneliti adalah penelitian kuantitatif dengan menggunakan data. Populasi penelitian ini adalah semua masyarakat desa dan perangkat desa di Manulea. Berdasarkan metode purposivesampling, jumlah sampel yang diperoleh adalah 50 orang. Data yang digunakan oleh peneliti adalah data primer dan data sekunder dengan teknik pengumpulan data menggunakan observasi dan kuesioner yang dianggap instrumen utama. Pada fase pengujian, peneliti menggunakan beberapa metode pengujian yang dianggap sangat penting untuk digunakan. Metode tersebut adalah: statistik deskriptif, statistik infrasional, tes asumsi klasik, pengujian hipotesis, dan ujikoefisien determinasi.Berdasarkan hasil penelitian yang telah dilakukan, dapat disimpulkan bahwa akuntabilitas dan transparansi secara parsial berpengaruh signifikan, terhadap pengelolaan alokasi dana desa. Sedangkan akuntabilitas dan transparansi secara simultan memiliki pengaruh yang signifikan terhadap pengelolaan alokasi dana desa dalam mewujudkan pemerintahan yang baik di Desa Manulea, Kabupaten Sasitamean, Kabupaten Malaka. Kata kunci: Pengelolaan Alokasi Dana Desa, Akuntabilitas, Transparansi.
SURTO DE INTOXICAÇÃO POR SÓDIO EM SUÍNOS NO SEMIÁRIDO DA PARAÍBA
Authors: Filho Hodias Sousa de Oliveira , Brito Mariely Pessoa de , Sousa Higor Gabriel Figueiredo de , Ramos Maria Estrela de Oliveira , Matias Isabela Calixto , Nascimento Maria Jussara Rodrigues do , Galize Glauco José Nogueira de , Maia Lisanka Ângelo
Published: September 2020

Descreve-se um surto de intoxicação por sódio em suínos no semiárido da Paraíba. Os suínos eram alimentados com soro de queijo,24 animais jovens adoeceram, 23 morreram e um foi eutanasiado e necropsiado. Os suínos demonstravam sinais neurológicos como incoordenação, tremores musculares, opistótono, andar em círculo e pressão da cabeça contra objetos, seguidos de óbito, pouco tempo depois. Na necropsia observou-se área focal acinzentada no córtex parietal e, microscopicamente, meningoencefalite eosinofílica associada à polioencéfalomalacia. O diagnóstico de intoxicação por sal em suínos foi realizado com base nos dados epidemiológicos, sinais clínicos e confirmado através dos achados histopatológicos. Conclui-se que a intoxicação por sal ocorre em suínos do alto sertão paraibano. O fornecimento de soro de queijo associada à privação de água foram responsáveis pelo quadro da intoxicação.
CONHECIMENTO DE CRIANÇAS DE ESCOLAS PÚBLICAS DE MOSSORÓ/RN SOBRE ZOONOSES
Authors: Alves Nilza Dutra , Soares Karla Karielly De Souza , Landim Camila Pontes , Santos Paula Vivian Feitosa dos , Rodrigues Gardênia Silvana de Oliveira , Feijó Francisco Marlon Carneiro , Oliveira Alysson Leno Marques de , Santos Caio Sérgio
Published: September 2020

As zoonoses são doenças transmissíveis entre os animais e os humanos, sendo a educação em saúde essencial para sua prevenção. A escola é um ambiente propício para abordar o tema, visto que a noção das crianças sobre zoonoses é um ponto essencial na saúde pública, pois assumem papel de difusoras de informação. O objetivo do trabalho foi avaliar o conhecimento de crianças de escolas públicas sobre zoonose. Foram entrevistados 80 alunos de escolas públicas em Mossoró/RN, entre 8 a 11 anos. Foi aplicado um questionário sobre o conceito de zoonose. Depois, foram realizadas atividades educativas sobre o tema e reaplicação dos questionários. Antes da realização das atividades, 100% responderam não conhecer zoonose. Após a reaplicação, 61,25% conheciam zoonose, porém 38,75% continuavam a não conhecer. Visto que houve alteração positiva no padrão de respostas dos alunos após as atividades em sala de aula, as ações educativas podem ser importantes na construção do conhecimento sobre zoonoses.