bluuebunny/crossref_metadata_2025 huggingface dataset:
MAGNESIUM ALLOYS: PROSPECTIVE INDUSTRIES OF APPLICATION, ADVANTAGES AND DISADVANTAGES (review) Part 1. Application in medicine. Crystallographic factors affecting the corrosion resistance of magnesium alloys
Authors:   Federal State Unitary Enterprise «All-Russian Scientific-Research Institute of Aviation Materials» of National Research Center «Kurchatov Institute», Petrov A.A. , Speransky K.A. ,   Federal State Unitary Enterprise «All-Russian Scientific-Research Institute of Aviation Materials» of National Research Center «Kurchatov Institute»
Published: October 2021

This article opens a series of publications in which the main problems of magnesium alloys will be considered, such as low corrosion resistance, high anisotropy of mechanical properties, low fire safety, as well as the industries of application of these materials. The cycle of works involves several parts, each of which is devoted to a separate macro-problem characteristic of magnesium alloys, or to industries in which magnesium alloys may be most in demand. This part of the review presents basic information and systems for alloying magnesium alloys. The crystallographic and structural factors influencing the corrosion resistance of magnesium alloys are described. The possibility of using magnesium alloys in medicine is shown, and the reasons for which at the current moment of time their use is difficult.
EVALUATION OF VIBRATION-ABSORBING MATERIAL BASED ON POLYURETHANE USING POSSIBILITY FOR A SEAL
Authors:   Federal State Unitary Enterprise «All-Russian Scientific-Research Institute of Aviation Materials» of National Research Center «Kurchatov Institute», Sagomonova V.A. , Dolgopolov S.S. ,   Federal State Unitary Enterprise «All-Russian Scientific-Research Institute of Aviation Materials» of National Research Center «Kurchatov Institute», Sorokin A.E. ,   Federal State Unitary Enterprise «All-Russian Scientific-Research Institute of Aviation Materials» of National Research Center «Kurchatov Institute», Tselikin V.V. ,   Federal State Unitary Enterprise «All-Russian Scientific-Research Institute of Aviation Materials» of National Research Center «Kurchatov Institute»
Published: October 2021

The article presents the results of a study of the operational properties of the VTP-1V grade material, including cold flow. It was found that the material of the VTP-1V grade hasn’t cold flow and, according to the complex of properties studied in the work, can be recommended as an alternative to layered polymeric composite materials used in the bolted joints of the aircraft wing rib. The possibility of operating VTP-1V in an environment of aggressive liquids was assessed and it was shown that the material is resistant to the effects of TC-1 fuel, including retaining low deformability under prolonged loading.
A semiotic approach to Greek internet memes during the Covid-19 pandemic
Authors: Bardakis Thomas
Published: October 2021

Since late 2019, Covid-19 has spread worldwide, and many people are obliged to stay at home for public health reasons. Confined to their homes, people worldwide flooded the internet by posting photos and images online with funny captions, attracting an abundance of comments, and proving that humor is a vital need even in the most challenging times. This paper focuses on original Greek internet memes (not those translated into Greek) through selected examples. The study aims to investigate fifteen representations about Covid-19 and the Greek experience of lockdown, focused on quarantine lifestyle issues in Greek social media groups (Facebook, Instagram, Twitter). Memes are explored as humorous and composite visual communication works that highlight how Covid-19 and quarantine have affected our everyday lives.
Contagion and capaciousness: The Shifting Worlds of Living Models
Authors: Genosko Gary
Published: October 2021

Today, most models are computer-generated simulations of some kind. However, there is a vast world of living models that serve the biomedical industries. Mouse models are discussed here, but in the context of the questions they raise about agency. Living models, it is maintained, can have abundant relations with their laboratory worlds, that is, they have a capaciousness that may be enhanced by processes of dirtying and wilding. The controlled introduction of contagions allows for living models to get messy in a productive way, expanding their lifeworlds as well as those of their handlers. Configurational enunciations of lively assemblages are detailed in terms of more robust microbial encounters, as well as the affective attunements and attachments of the dirty mice initiative in biomedical laboratories.
An In vivo Experimental Study on Investigation of the Osseointegration of Zeolites A and Silicalite in Rats
Authors: Ceyhan Taşkın , Gülçubuk Ahmet , Tatlıer Melkon , Haktanır Damla , Kocaelli Hümeyra
Published: October 2021

Background: Zeolites are naturally occurring and can be artificially synthesized hydrated microporous crystallized aluminosilicates. Thus far, medical materials have comprised polycrystalline materials, glass, glass-ceramics and ceramic-filled composites for bone repair. The study aimed to investigate the potential in vivo osseointegration of two types of zeolites (A and silicalite) in rats by histologically presenting the repair process. Methods: Bone cavities of 1 mm3 were formed in rats and filled either with zeolite A or silicalite to investigate the possibility of using zeolites to repair bone defects. A comparative histological evaluation was performed regarding the interaction of zeolites with bone tissue and their osseointegration capacity for 15, 30 and 45-day intervals. Result: According to the results obtained, the growth of both fibrous and bone tissues took place around the zeolites placed in the live organism. It was observed that the zeolites used in this study did not give rise to necrosis, local tissue reaction, allergic or and any other harmful response. In conclusion, histopathology revealed that zeolites A and silicalite were biocompatible with the bone and could integrate with it at certain time intervals.
​Impact of Dietary Aflatoxin-B1 on Juvenile Growth in White Pekin Ducks
Authors: Mishra S.K. , Jena C.R. , Naik P.K. , Kumar D. , Swain B.K. , Panda S.K. , Pamia J. , Jena G.R.
Published: October 2021

Background: Aflatoxicosis in ducks is reckoned as a challenge for nutritionists worldwide, for its adverse impacts on growth. A study was conducted to ascertain the precise level of Aflatoxin-tolerance in White Pekin ducklings during juvenile ages. Methods: Day-old-ducklings (240) were randomly distributed into 3 experimental-groups viz., Control ( less than 0.5 ppb), T1 (200 ppb), T2 (400 ppb) and reared for measuring weekly growth, feed efficiency and blood biochemical changes, with treatments terminated at 6weeks age. Result: There was significant depression in live weights for both dietary-toxin groups from 2nd week onwards till completion. Mortality (0-6 weeks) was 85% in T2, while T1 was in between control and T2, both for mortality (45%) and morbidity. Feed-consumption and conversion for either toxin groups remained significantly (p≤0.05) poor, with T2 resulting in erratic FCRs, ranging from 1.23 to 4.95, across weeks. A typical AFB1-induced lameness in ducklings beyond 3 weeks of AFB1-exposure, emerged as a hallmarked morbidity, in varied proportions, in T1 and T2, but not in control. The study confirms that acute-depression of juvenile growth and high-morbidity are distinct outcomes from AFB1’s presence in Pekin diets @ 200 ppb level or higher, with such leg deformities emerging as hallmarked features of Pekins reared on AFB1-spiked diets. It can be concluded that, while the AFB1 content of juvenile White Pekin ducks should be kept limited to the recommended safe levels ( less than 10 ppb); exceeding a threshold of 200 ppb is sure to cause poor growth and FCR, with adverse blood biochemical changes, high mortality, morbidity and lameness.
Effect of L-cysteine Supplementation on Cryopreservation of Black Bengal Buck Semen
Authors: Tudu Krushna Chandra , Sarkar Debajyoti , Mandal Ajoy , Mondal Mohan , Das Subrata Kumar , Rai Saroj , Behera Rajlaxmi , Bhakat Champak , Karunakaran Muthupalani
Published: October 2021

Background: Black Bengal goat is one among the valuable goat breeds of India. Semen preservation and artificial insemination are practical technologies for conservation and improving livestock germplasm. Various biochemical changes that occur during cryopreservation of semen, results in loss of sperm cell structure and their functions. Inclusion of antioxidants to the semen extender has been reported to have positive effects on sperm recovery in various livestock species. The present experiment was carried out to evaluate the effect of antioxidant L-cysteine on post freeze thaw sperm characters, lipid peroxide level and superoxide dismutase (SOD) activity during cryo­preservation of Black Bengal buck semen. Methods: Twenty numbers of semen ejaculates were collected from Black Bengal bucks, antioxidant L cysteine was added to the semen extender @ 0, 1 and 2 mM in control group (CC), treatment group 1 (CT1) and treatment group 2 (CT2), respectively. Semen samples were frozen in liquid nitrogen and measured post freeze-thaw in vitro sperm characters, malondialdehyde (MDA) concentration and SOD activity. Result: Though there was no significant improvement in post thaw sperm motility, functional membrane integrity and viability count, supplementation of L-cysteine significantly improved the percentage of sperm cells with intact acrosome and significantly (P less than 0.05) reduced the level of malondialdehyde. Post thaw SOD activity was found significantly lower in the antioxidant treated groups than the control. It is concluded that supplementation of L cysteine is effective in controlling lipid peroxidation and conserving in vitro sperm characters during freezing of Black Bengal buck semen.
Trichoderma asperellum (NST-009): A Possible Thai Native Antagonistic Fungus for Managing White Root Disease of Rubber Trees (Hevea brasiliensis)
Authors: Promwee Athakorn , Intana Warin , Khomphet Thanet
Published: October 2021

Background: Rigidoporus microporus causes white root disease, which is one of the most harmful diseases in rubber trees in Thailand. The objectives of this study were to determine the efficacy of T. asperellum NST-009 and its antifungal metabolite in inhibiting R. microporus mycelial development and efficacy of T. asperellum NST-009 in controlling white root disease of rubber trees in an open-field house experiment. Methods: Four native strains of T. asperellum from Nakhon Si Thammarat Province and a commercial strain of Thailand were used in this study. This study was conducted at Agricultural Microbial Production and Service Center, Walailak University, Nakhon Si Thammarat, Thailand, during the period 2017-2020. Result: T. asperellum NST-009 significantly inhibited R. microporus mycelial growth by 77.07% in vitro and its antifungal metabolite from the culture filtrate of T. asperellum NST-009 inhibited mycelial growth by 92.31%. T. asperellum NST-009 reduced the disease severity index by 76.38% in the open-field house experiment compared to the inoculated control. Furthermore, T. asperellum NST-009 was found to survive in rhizosphere soil at 4.50 × 105 CFU/g soil and colonized the roots at 100.00%.
Estimasi Parameter Capital Assets Pricing Model Dengan Metode Generalized Method of Moments Dalam Perhitungan Value At Risk
Authors: Wahyuni Diah Maghfiroh , Aziz Abdul , Juhari Juhari
Published: October 2021

Capital Assets Pricing Model merupakan persamaan regresi antara premi risiko aset terhadap premi risiko pasar. Risiko ada jika pembuat keputusan tidak memiliki data untuk menyusun suatu dugaan. Pendugaan tersebut dapat dilakukan dengan generalized method of moments.Penelitian ini bertujuan untuk mengetahui hasil estimasi parameter pada Capital Assets Pricing Model menggunakan Generalized Method of Moments pada data saham PT. Indofood Tbk., serta mendapatkan nilai Value at Risk pada data saham PT. Indofood Tbk..Hasil yang diperoleh  yaitu :  , m=1,2,…. Dengan nilai  maka model regresi pada saham PT. Indofood Tbk.. yaitu . Dengan tingkat signifikansi 5%, investasi awal Rp10.000.000,00 , kerugian yang akan ditanggung oleh investor adalah Rp1.265.800,00 .
Agression against teenagers with health disabilities
Authors:   Baku State University, Ibadullaeva N.T.
Published: October 2021

Identified are the essence and indicators of aggression at the level of interpersonal relations in the educational environment of Azerbaijan were identified. The phenomenon of bullying has been found to consist of systematic or temporary physical or psychological violence committed in a group or individually, with an emphasis on a person who is mentally or physically weak. Under the conditions of bullying, high school students develop a stable relationship between the “victim” and the “criminal”. It is shown that the positive attitude of high school students, individual adaptive potential and neuropsychological stability, activity in interpersonal interactions and positive perception of others, reduction of anxiety can be an important condition for the formation of a number of positive psychological characteristics. Aggression is based on a difficult life situation. The most active factors of the viability of such behavior of schoolchildren who are participants in violence in the educational environment have been identified.
Preservação de documentos audiovisuais
Authors: Machado João Guilherme Nogueira , Mardero Arellano Miguel Angel , Lopes Cleomar Huche
Published: October 2021

O entendimento teórico sobre o que os repositórios digitais se propõem a preservar vem do aprendizado prático de uso e interpretação das ações geradas por esses softwares cada vez mais indispensáveis. A preservação de documentos audiovisuais e suas especificidades, sobretudo a variedade de formatos físicos, formatos digitais de contêineres e codecs, assim como seu alto volume de dados faz com que esse gênero documental mereça uma atenção diferenciada no seu tratamento arquivístico de preservação. O trabalho aqui proposto utilizou como ferramenta de preservação a ser testada o repositório Archivematica na versão 1.9.1, no contexto do seu uso prático para tratamento de documentos audiovisuais que compõem o acervo da VideoSaúde – Distribuidora (VSD) da Fiocruz. Os resultados obtidos foram descritos e avaliados quanto a sua capacidade de criação de pacotes de informação de submissão (SIP), geração de pacotes de informação de arquivamento (AIP) e interpretação de metadados METS dos AIP. Nesse sentido, concluiu-se que a estrutura dos SIP elaborados para teste no software atendeu aos parâmetros de processamento para geração de AIP completos e robustos. Entretanto, destaca-se que testes com outros formatos e abordando outras especificidades de vídeo devem ser pesquisados para complementação da análise sobre o uso da ferramenta frente à preservação digital de documentos audiovisuais.
Does India’s Menstrual Hygiene Management Scheme exclude the disabled?
Authors: Dutta Daisy , Chakraborti Chhanda
Published: October 2021

The Menstrual Hygiene Scheme of the Government of India wishes to generate awareness among adolescent girls, and provide them with hygienic and affordable sanitary napkins. The scheme has been criticised for many reasons by various reviewers. However, we draw attention to a hitherto unaddressed gap that the scheme has effectively overlooked, the menstrual hygiene needs of disabled adolescent girls, and has thereby denied them their right to health and healthcare. This exacerbates health disparities, and raises questions of public health ethics. We conclude with recommendations on how to redress the situation and make the scheme more inclusive.
Exploring the Use of Student-Developed Outreach Videos to Provide Mental Health Wellness Education-A Pilot Project
Authors: Reid Kristin , Armstrong Nancy , Todd Dana
Published: October 2021

BACKGROUND: Mental health and wellness outreach has been an area of concern at colleges and universities in the United States and a variety of electronic methods have been used to successfully promote health and wellness. This pilot project was in response to a previous descriptive study examining mental health issues on campus. AIMS: The primary aim of this project was to determine if implementing a peer-led outreach program in the form of bi-weekly, short-form educational videos would increase knowledge of mental health and wellness in students developing the videos. The secondary aim was to provide students an alternate clinical assignment that improved presentation development and group dynamics. METHODS: Nursing students enrolled in a psychiatric nursing course collaborated in small groups to create bi-weekly videos on topics related to mental health and wellness. RESULTS: The peer-led outreach intervention demonstrated positive outcomes, such as increased understanding of the common mental health issues facing college students and awareness of campus, as well as outside resources to assist with mental health and wellness. CONCLUSION: This project may increase the body of knowledge related to the importance of campus outreach, peer support, and general awareness of mental wellness and resources during pandemic restraints. Utilizing condensed, peer-led educational outreach via video format has the potential to aid in the educational development of psychiatric nursing students.
New options for preeclampsia prevention
Authors:   Krasnoyarsk State Medical University named after Prof. V.F.Voino-Yasenetsky, Krasnoyarsk, Russian Federation, Tskhay V.B. ,   Federal Siberian Research Clinical Center under the Federal Medical Biological Agency of Russia, Krasnoyarsk, Russian Federation, Schindler A.E. ,   Institute for Medical Research and Education, Essen, Germany
Published: October 2021

The analysis of literature data on the role of placenta disorders in the development of preeclampsia (PE) was performed according to Pubmed and eLibrary updates. Although a complete understanding of the pathogenesis of PE remains unclear, the placenta theory was found as one of the principal ones. The appropriateness of prescribing progestogens for the prevention of PE is the subject of an actual debate. Based on the results of our own research, there was demonstrated the efficacy in the preventative prescription of dydrogesterone (at a dose of 30 mg/day) from early periods to 20 weeks of gestation in pregnant women with high-risk factors. The rescription of dydrogesterone contributed to a statistically significant reduction in this pregnancy complication (13.1 and 71/4%, p < 0,001).It was found that women taking dydrogesterone significantly less developed such disorders as arterial hypertension (3.2 and 71.2%, p < 0.001), proteinuria (0 and 66.18%, p < 0.001), fetal growth restriction (2.2 and 21.58%, p < 0.001), uteroplacental vascular insufficiency (3.2 and 21.58%, p < 0.001), and preterm birth (8.6 and 53.95%, p < 0.001). Conclusion. The importance of the placental factor in the pathogenesis of PE, the prescription of progestogens corresponds to the main principle of pathogenetic prevention of this complication. Administration of dydrogesterone in the first and second trimesters (6 to 20 weeks of pregnancy) significantly reduces the incidence of PE in high-risk pregnant women. Key words: preeclampsia, prevention, high-risk groups, progestogens, dydrogesterone
Oxidative stress parameters and pro-inflammatory status of patients with menstrual disorders against obesity treatment
Authors:   Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation, Glazkova O.L. , Podzolkova N.M. ,   Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation, Shmeleva S.V. ,   K.G.Razumovsky Moscow State University of Technologies and Management, Moscow, Russian Federation, Baymeeva N.V. ,   Clinical Diagnostic Laboratory “EuroTest” LLC, Moscow, Russian Federation
Published: October 2021

Objective. To study the effect of cyclical vitamin therapy on the parameters of oxidative stress and pro-inflammatory status of patients with menstrual disorders against the background of obesity treatment. Patients and methods. The study included 49 women aged 20 to 35 years (29.4 (26.5; 33.2) years) with obesity and various menstrual disorders. Twenty-six (53.06%) patients had polycystic ovary syndrome (PCOS). To treat obesity, 26 patients followed a diet and received Orlistat 120 mg three times a day. Twenty-three women received similar treatment and additionally took micronutrient supplements. In both groups, treatment was continued for 4 months. Results. Body mass index decreased by 1.9 (0.3; 2.3) kg/m2 in the group of women who received Orlistat, and by 1.6 (0.5; 2.7) kg/m2 in the group of women who received Orlistat and vitamins. Menstrual cycle normalized in more than a third of patients in each group. Baseline levels of oxidative stress and C-reactive protein concentrations were abnormal in all patients, especially in PCOS. Decrease of tocopherol (12.8 (6.6; 14.7) μg/mL; 7.1 (3.4; 9.1) μg/mL, p = 0.04) and beta-carotene (680.1 (320.3; 810.3) μg/mL; 420.3 (150.4; 510.1) μg/mL, p = 0.01) concentrations in the blood of patients who did not receive vitamins during treatment was expected, as was their increase in those who took vitamins (tocopherol 10.1 (4.5; 15.1) μg/mL; 13.2 (7.1; 15.9) μg/mL, p = 0.045; beta-carotene 610.4 (450.3; 710.5) μg/mL; 630.4 (570.3; 790.5) μg/mL, p > 0.05). In the blood of those patients who received vitamins, the concentration of the antioxidant ubiquinone (0.6 (0.3; 1.4) μg/mL; 1.1 (0.5; 1.7) μg/mL, p = 0.002) increased, and the positive dynamics of oxidative stress parameters were more considerable and statistically more significant. Conclusion. Supplementation of micronutrient complex in the treatment of obesity helps to improve the parameters of antioxidant protection and pro-inflammatory status. Key words: obesity, menstrual disorders, oxidative stress, pro-inflammatory status, cyclical vitamin therapy
Expression of long non-coding RNAs ROR and MALAT1 in uterine fibroids
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Levakov S.A. , Azadova G.Ya. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Mamedova A.E. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Movtaeva Kh.R. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Maslyakova M.I. ,   National Research University Higher School of Economics, Moscow, Russian Federation, Pavlyukov M.S. ,   Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russian Federation, Shakhparonov M.I. ,   Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russian Federation, Antipova N.V. ,   National Research University Higher School of Economics, Moscow, Russian Federation,   Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russian Federation
Published: October 2021

Objective. To study the expression level of long non-coding RNAs ROR and MALAT1 in tissue samples of uterine fibroids. Patients and methods. Samples of myomatous nodes and tissues of normal myometrium in 28 women of reproductive age were examined. The analysis of the expression of long non-coding RNAs was carried out using a real-time reverse-transcription polymerase chain reaction (RT-PCR) with specific primers. Results. There was a significant decrease in the expression level of long non-coding RNA ROR and an increase in the MALAT1 expression in tissue samples of uterine fibroids relative to the control group. Conclusion. The results obtained demonstrate a possible role of long non-coding RNAs in the development of uterine fibroids and correlate with the data which we obtained for patients with endometriosis. Detecting the expression level of long non-coding RNAs can improve the existing methods for diagnosing this disease. However, further research is required to determine the clinical significance of MALAT1 and ROR, and the molecular mechanisms underlying the action of these RNAs in uterine fibroid cells. Key words: long non-coding RNAs, uterine fibroids, myomectomy, lncROR, MALAT1
Penggunaan WhatsApp Grup Sebagai Media Pembelajaran Daring selama Pandemi COVID-19
Authors: Budiyanti Rani Tiyas , Permata Ganggi Roro Isyawati , Herlambang Penggalih Mahardika
Published: October 2021

Latar Belakang : Pandemi Coronavirus Disease -19 (COVID-19) memberikan dampak pada berbagai sektor kehidupan termasuk diantaranya adalah sektor pendidikan. Himbauan mengenai physical distancing selama masa pandemi dan era new normal membuat ranah pendidikan mengoptimalisasikan pembelajaran melalui daring (online). Terdapat berbagai media pembelajaran yang dapat digunakan dalam pembelajaran online, salah satunya dengan memanfaatkan instan messaging seperti WhatsApp Grup. Penelitian ini bertujuan untuk mengetahui efektivitas penggunaan WhatsApp Grup sebagai media pembelajaran selama pandemic COVID-19.

Metode : Penelitian bersifat deskriptif analitik dengan pengumpulan data melalui survei online menggunakan google form. Jumlah responden sebanyak 398 mahasiswa yang telah mendapatkan 3 sesi perkuliahan dengan menggunakan WhatsApp Grup. Waktu penelitian berlangsung pada bulan April hingga Mei 2020.

Hasil : Berdasarkan penelitian, sebanyak 269 responden (67,6%) menyebutkan WhatsApp Grup efektif sebagai media pembelajaran, dengan 350 responden (87,9%) memiliki nilai post test ≥70. WhatsApp Grup memiliki beberapa keuntungan seperti hemat kuota dan dapat dikombinasikan dengan berbagai fitur pembelajaran. Sedangkan kekurangan dalam media ini adalah mahasiswa mudah terdistraksi dengan chat lain dan sukar diterapkan pada pembelajaran yang melibatkan presentasi mahasiswa.

Kesimpulan : WhatsApp Grup dapat digunakan sebagai alternatif media pembelajaran daring di masa pandemi COVID-19. Meskipun demikian, kombinasi penggunaan teks, gambar, video, dan games perlu dilakukan sehingga dapat memfasilitasi berbagai gaya belajar mahasiswa baik audio maupun visual.
Buku Ajar Instrumentasi Medis Dan Aplikasinya
Authors: Suprayitno Eko Agus
Published: October 2021

Kemajuan teknologi dibidang kesehatan dalam mendukung kerja dokter melakukan diagnosa penyakit yang aman, akurat, efektif, dan tidak menimbulkan rasa sakit berlebihan serta mampu membantu masyarakat dalam mendapatkan penanganan medis yang lebih baik. Perkembangan Instrumentasi medis tersebut tidak lepas dari hasil kerja sama antara tenaga kesehatan dan engineer. Sehingga diperlukan integrasi keilmuan secara ilmiah antara engginer dalam memberikan solusi kecanggihan teknologi dan tenaga medis dalam kontribusi keilmuan medis terkait penyakit maupun anatomi fidiologi tubuh, agar menghasilkan teknologi di bidang medis yang akurat dan aman
Buku Ajar Mata Kuliah “Elaborasi Pendidikan Islam: Konsep dan Kajian Islam
Authors: Nadlif Ainun
Published: October 2021

Puji syukur kehadirat Allah swt., Tuhan Yang Maha Esa hanya kepada-Nya kita berserah diri dan mencari ridlaNya. Semoga kita selalu memperoleh petunjuk dan bimbinganNya kejalan yang benar dan mampu meraih kebahagiaan hidup di dunia dan akherat. Shalawat serta salam tetap tercurahkan kepada Nabi Muhammad saw hamba Allah swt terbaik, keluarga, sahabat, dan para pengikutnya yang selalu tunduk kepada ajaran yang disampaikannya. Memasuki awal abad XXI, pendidikan Islam sangat dibutuhkan oleh Ummat. Pendidikan Islam yang diharapkan dalam hal ini adalah pendidikan yang mampu menguatkan nilai-nilai ajaran Islam dalam kehidupan masyarakat. Pendidikan Islam yang mampu mencegah keruntuhan akhlak dan perilaku generasi Bangsa dan Ummat, karena intelektual berkembang dengan cepat, teknologi semakin pregressive, sementara kehidupan beragama dan keyakinan terhadap agama semakin terkikis. Buku yang ada dihadapan pembaca ini berjudul “Elaborasi Pendidikan Islam: Konsep dan Kajian Islam” disusun sebagai bahan introspeksi akan pentingnya eksistensi pendidikan Islam. Konsep Pendidikan dan realita pendidikan adalah dua aspek yang saling berkaitan, karena pendidikan Islam selalu memotret persoalan manusia dari tiga aspek utama pendidikan yaitu, manusia butuh belajar, manusia harus dibimbing, dan manusia harus dilatih. Dalam konteks tersebut, Pendidikan Islam harus disajikan tanpa batas dan tanpa mengenal waktu dan perubahan, karena ia akan dibutuhkan oleh setiap perubahan zaman. Buku “Elaborasi Pendidikan Islam” sangat penting dibaca oleh Mahasiswa Fakultas Agama Islam, Guru-guru Agama Islam baik yang berada di lembaga pendidikan umum maupun Guru-guru dilembaga pendidikan bercirikan Islam sebagai referensi/rujukan kajian pendidikan Islam saat ini.
In Vitro and in Silico Analysis of Recombinant Arginine Deiminase from Pseudomonas Furukawaii as a Potential Anticancer Enzyme
Authors: Dhankhar Rakhi , Gupta Vatika , Mohanty Aparajita , Gulati Pooja
Published: October 2021

Arginine deiminase (ADI) is a promising anti-tumor enzyme that can be employed in amino acid deprivation therapy for the treatment of various arginine auxotrophic tumors. In our previous work, Pseudomonas furukawaii was identified as a potent producer of ADI with optimum activity at physiological pH and temperature. In this study ADI coding arcA gene was cloned and expressed in E. coli BL21. Recombinant ADI of P. furukawaii (PfADI) was purified using affinity chromatography and its molecular mass was estimated to be ~46KDa. PfADI was found to effectively inhibit the HepG2 cells with an IC50 value of 0.1950 IU/ml which is lower than the IC50 value of Mycoplasma hominis ADI (MhADI) which is in phase III clinical trials. The 3D structure of PfADI was modeled. Immunoinformatics analysis was also carried out to compare the immunogenicity of PfADI with MhADI. The PfADI was found to be less immunogenic in terms of number of linear and conformational B cell epitopes and T cell epitope density. The overall antigenicity and allergenicity of PfADI was also lower as compared to MhADI. Thus the present in vitro and in silico studies establish PfADI as a potential anticancer drug candidate with improved efficacy and low immunogenicity.
EATMR: An Energy-Aware Trust Algorithm Based the AODV Protocol and Multi-path Routing Approach in Wireless Sensor Networks
Authors: Yin Huaying , Yang Hongmei , Hajiee Maryam
Published: October 2021

Rapid developments in radio technology and processors have led to the emergence of small sensor nodes that provide communication over Wireless Sensor Networks (WSNs). The crucial issues in these networks are energy consumption management and reliable data exchange. Due to the limited resources of sensor nodes, WSNs become a vulnerable target against many security attacks. Thus, energy-aware trust-based techniques have become a powerful tool for detecting nodes’ behavior and providing security solutions in WSN. Clustering-based routings are one of the most effective methods in increasing the WSN performance. In this paper, an Energy-Aware Trust algorithm based on the AODV protocol and Multi-path Routing approach (EATMR) is proposed to improve the security of WSNs. EATMR consists of two main phases: firstly, the nodes are clustered based on the Open-Source Development Model Algorithm (ODMA), and then in the second phase, clustering-based routing is applied. In this paper, the routing process follows the AODV protocol and multi-path routes approach with considering energy-aware trust. Here, the optimal and safe route is determined based on various parameters, namely energy, trust, hop-count, and distance. In this regard, we emphasize the evaluation of node trust using direct trust, indirect trust, and a multi-objective function. The simulation has been performed in MATLAB software in the presence of a Denial of Service (DoS) attack. The simulation results show that EATMR performs better than other approaches such as M-CSO and SQEER in terms of successfully detecting malicious nodes and enhancing network lifetime, energy consumption, and packet delivery ratio.
Microstructure and Microsegregation Characterization of Laser Surfaced Remelted Al-3wt%Cu Alloys
Authors: Yao Zhenjie , Ren Wenjing , Allison John
Published: October 2021

Solidification rates during laser remelting of solid metals occur under solidification conditions that are far from equilibrium conditions. The microstructural evolution and microsegregation behaviors are affected by these conditions. This study comprised an experimental characterization of the ultra-fine microstructure and microsegregation in laser surface remelted regions of a hypoeutectic Al-Cu alloy. The laser scan speed, which controls the cooling rate within the remelted region, was observed to have a significant effect on microstructural features and microsegregation. Dendrite arm spacing was determined to decrease with increasing scan speed and depended on location within the melt pool. A transition of the dendrite morphology was also observed in the melt pools. This transition, which is attributed to the grain orientation change influenced by the laser beam movement, was experimentally characterized. The measured microsegregation profiles show decreasing microsegregation as cooling rate increases which is typically of increasing undercooling and non-equilibrium solidification.
A Novel Long Non-Coding RNA (Ctcflos) Modulates Glucocorticoid Receptor-Mediated Induction of Hepatic Phosphoenolpyruvate Carboxykinase in Mice
Authors: Yoon Jae-Yeun , Kim Ju-Yeon , Ka Na-Lee , Lee Sang-Heon , Lee Mi-Ock
Published: October 2021

Background
Phosphoenolpyruvate carboxykinase (Pck1) is a key enzyme that catalyzes an irreversible step of hepatic gluconeogenesis; however, the mechanism underlying Pck1 regulation is not fully understood. This study aims to identify a lncRNA that regulates transcription of the Pck1 gene.
Methods
The precise structures of five different hepatic Ctcflos isotypes were identified through rapid amplification of cDNA ends in the mouse liver. The expression level of hepatic Ctcflos level was determined by PCR and the role of Ctcflos were assessed using antisense oligonucleotides and virus encoding Ctcflos both in vitro and in vivo. The target protein interacted with Ctcflos was identified through RNA pull down assay. Contribution of Ctcflos in glucocorticoid receptor (GR)-mediated Pck1 gene expression was evaluated by chromatin immunoprecipitation, co-immunoprecipitation, in situ proximity ligation assay, and reporter gene analysis.
Results
A novel lncRNA Ctcflos was identified in the enhancer region of Pck1 gene. Induction of Ctcflos was dependent on the glucocorticoid receptor (GR) in the livers of fasted or dexamethasone-administered mice. Overexpression of Ctcflos by infusion of an adenovirus encoding Ctcflos increased transcript- and protein-level of Pck1, whereas knockdown of Ctcflos using antisense oligonucleotides suppressed. RNA pulldown experiments showed that Ctcflos bound the heterogeneous ribonucleoprotein L (hnRNPL) which interacts with GR. Interestingly, knockdown of hnRNPL upregulated the Pck1 gene. Finally, we found that, in the presence of Ctcflos, the binding between GR and hnRNPL was weakened, whereas the DNA binding of GR was enriched in the Pck1 enhancer region.
Conclusions
We report the discovery of a novel lncRNA, Ctcflos, that regulates the transcription of Pck1 by modulating GR function. Targeting Ctcflos may provide a new insight into the development of alternative treatments for hyperglycemia by offering specific regulation of hepatic Pck1 gene expression.
Cucurbitacin B Controls M2 Macrophage Polarization to Suppresses Metastasis via Targeting JAK-2/STAT3 Signalling Pathway
Authors: Zhang Haoyue , Zhao Bei , Yan Yu , Zeng Hairong , Sheng Dongya , Zhang Yang
Published: October 2021

Background

Colorectal cancer is one of the most high-risk human malignant tumors. Tumor-associated macrophages (TAMs) represent a substantial proportion of all tumor-infiltrating immune cells in the tumor microenvironment (TME), as it generally displays M1 or M2 phenotype with tumor-inhibiting or tumor-promoting activity. Cucurbitacin B has been reported to produce varieties of pharmacological effects for the treatment of cancer.
Methods

Cell viability and proliferation were measured by CCK8 as well as colony formation assays, and cell apoptosis were analyzed by flow cytometry. The underlying mechanism was determined using western blot, microscale thermophores and immunofluorescence assays. In addition, the supernatant of cucurbitacin B-induced M2-like macrophages and colon cells were co-cultured in vitro, transwell and wound healing assay were employed to the related phenotypes. Two mouse model were established to investigate the anti-apoptosis and anti-metastasis of cucurbitacin B.
Results

Herein, our study was performed to evaluate the anti-tumor and anti-metastasis effect of cucurbitacin B. It was observed that cucurbitacin B inhibited the phosphorylation of JAK2 and STAT3, and translocation from the cytosol to the nucleus. Meanwhile, we observed that cucurbitacin B bound to STAT3. Further experimentation demonstrated that cucurbitacin B reduced the polarization of M2 macrophage by down-regulating JAK2/STAT3 signaling pathway. Cucurbitacin B-induced M2-like macrophages was found to diminish the migration of CRC cells. In vitro study suggested that cucurbitacin inhibited the CRC cells proliferation via JAK2/STAT3 and suppressed the cell migration by suppressing M2-like macrophages polarization. Consistent with in vitro results, the cucurbitacin B therapy significantly inhibited tumor growth and metastasis in mice. Moreover, in vivo the treatment with cucurbitacin B enhanced anti-tumor immunity by regulating M2-like macrophages and promoted the expression of CD4 and CD8 in tumor microenvironment.
Conclusion

Collectively, our results provided that cucurbitacin B might be a potential candidate agent for adjuvant therapy in the process of CRC growth and metastasis.
Machine Learning Based Real Time-Heuristic Sensor Data Analytics For Early Warning Prediction
Authors: Pal Shelendra , Mishra Divyendu Kumar , Haldorai Anandakumar , Parvathy L. Rama , Janupriya S. , Babu D.Vijendra
Published: October 2021

Landslides have the potential to cause significant property damage as well as fatalities. Landslides are identified by real-time heuristic data analysis acquired using wireless sensor networks (WSNs) in changing environments. People can abandon dangerous locations earlier when landslides are forecasted. In this paper, the early warning prediction system developed using machine learning; Artificial Neural Networks (ANNs) provide precise predictions. The weight coefficients of ANN can be adjusted exactly enough by network functional training. In the case of unbalanced data distribution, the proposed ANN model is unable to learn the sample data pattern. This results in incorrect prediction and therefore, a switching method is utilized to switch between alternative predictors based on the current environmental state. Furthermore, the proposed model has been developed to forecast and compensate for errors during the prediction phase. Thus, the proposed model can enhance precise prediction, and an early warning prediction system of landslides can issue warnings 44.2 minutes before a landslide occurrence.
Real-time Visibility, Operational Insights and Actions with SAP Operational Process Intelligence, powered by HANA
Authors: Jegadeesan Harsh
Published: October 2021

Over the past decade, business operations in organizations are increasingly generating vast amounts of data. This steep increase in operational data – often known as big data – is a result of organizations capturing data at more fine-granular levels in business operations. Leveraging operational big data to improve business operations can create a sustainable competitive advantage to organizations. In this paper, we argue that operational big data is ”dead data” unless it is contextualized and made actionable for line-of-business users. Moreover, we explain how organizations can use SAP Operational Process Intelligence and the power of HANA to first, contextualize operational big data for real-time operational intelligence, second, provide line-of-business users visibility into business operations and business situations as they evolve and third, propose appropriate actions to respond to these business situations and help them reach business outcomes.
On Weighted Pál Type (0,2)-interpolation on the Unit Circle
Authors: Bahadur Swarnima , Bano Sariya
Published: October 2021

In this paper, we study the explicit representation of weighted Pál-type (0,2)-interpolation on two pairwise disjoint sets of nodes on the unit circle, which are obtained by projecting vertically the zeros of (1−x2)Pn(x) and Pn′′(x) respectively, where Pn(x) stands for nth Legendre polynomial.AMS Classification (2000): 41A05, 30E10.
The Value of ROX Index in Predicting the Outcome of High Flow Nasal Cannula: A Systematic Review and Meta-analysis
Authors: Junhai Zhen , Jing Yan , Beibei Cao , Li Li
Published: October 2021

Background: High flow nasal cannula (HFNC) therapy is widely employed in acute hypoxemic respiratory failure (AHRF) patients. However, the techniques for predicting HFNC outcome remain scarce.Methods: PubMed, EMBASE, and Cochrane Library were searched until April 20, 2021. We included the studies that evaluated the potential predictive value of ROX (respiratory rate-oxygenation) index for HFNC outcome. This meta-analysis determined sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic score, diagnostic odds ratio (DOR), and pooled area under the summary receiver operating characteristic (SROC) curve.Results: We assessed nine studies with 1933 patients, of which 745 patients experienced HFNC failure. This meta-analysis found that sensitivity, specificity, PLR, NLR, diagnostic score, and DOR of ROX index in predicting HFNC failure were 0.67 (95% CI 0.57-0.76), 0.72 (95% CI 0.65-0.78), 2.4 (95% CI 2.0-2.8), 0.46 (95% CI 0.37-0.58), 1.65(95% CI 1.37-1.93), and 5.0 (95% CI 4.0-7.0), respectively. In addition, SROC was 0.75 (95% CI 0.71-0.79). Besides, our subgroup analyses revealed that ROX index had higher sensitivity and specificity for predicting HFNC failure in COVID-19 patients from non-European countries, while the acquisition time of 6 h after receiving HFNC had a lower sensitivity and specificity when compared to other times.Conclusions: This study demonstrated that ROX index could function as a novel potential marker to identify patients with a higher risk of HFNC failure. However, the prediction efficiency was moderate, and additional research is required to determine the optimal cut-off value and propel acquisition time of ROX index in the future.PROSPERO registration number: CRD42021240607.
Evaluation of a Large-Scale School Wellness Intervention Through the Consolidated Framework for Implementation Research (CFIR): Implications for Dissemination and Sustainability
Authors: McLoughlin Gabriella M , Sweeney Rachel , Liechty Laura , Lee Joey A. , Rosenkranz Richard R. , Welk Gregory J.
Published: October 2021

BackgroundAlthough comprehensive approaches to student health promotion through wellness policy implementation show potential for scale-up, scant empirical research has been conducted to meaningfully integrate dissemination and implementation (D&I) in evaluation procedures. Such application is necessary to understand how and why interventions are sustained over time. The aims of this study were to investigate: 1) implementation determinants of adoption, fidelity, and penetration for school-wide wellness programming; and 2) nuanced determinants between schools with prior experience and those new to the program, to enhance tailored implementation support and sustainability.MethodsThe School Wellness Integration Targeting Child Health (SWITCH®) capacity-building intervention was adopted in 52 elementary and middle (22 new; 30 experienced) schools across Iowa, United States in the 2019–2020 academic year. The Consolidated Framework for Implementation Research (CFIR) guided development of mixed methods data collection and analysis protocols, adapted to school settings. Determinants from CFIR were linked to three key implementation outcomes: 1) fidelity/compliance to established quality elements; 2) adoption of best practices in multiple settings; and 3) penetration of behavior change practices across classrooms and grade levels. Organizational readiness/capacity was also assessed at baseline. Interview data were scored using a systematic process; each CFIR domain was assigned a score (ranging between -2 and +2) to denote either a positive or negative influence on implementation. Independent t-tests were conducted to capture potential differences between new and experienced schools, followed by Pearson bivariate correlation analyses to determine relationships between CFIR determinants and implementation outcomes. ResultsIn experienced schools, fidelity/compliance (t=-1.86 p=.07) and adoption (t=-2.03 p=.04) were slightly higher than new schools. The CFIR determinants of innovation source, culture and relative priority, and leadership engagement were positively related to implementation outcomes, whereas tension for change and networks and communications were observed negative determinants. Unique negative determinants for new schools comprised relative advantage, engaging key stakeholders, and reflecting/evaluating, among others. ConclusionsFindings provide specific areas of need where implementation support may be most valuable, especially for new schools undertaking a comprehensive program such as SWITCH. Tailoring implementation support to both new and existing settings will ultimately enhance dissemination and sustainability of evidence-based interventions.
Resilient Anti-disturbance Dynamic Surface Control of Uncertain Strict-feedback Systems Subject to Partial Loss of Actuator Effectiveness
Authors: Liu Lu , Yang Anxin , Chen Weixing , Zhang Weidong
Published: October 2021

This paper is concerned with the tracking control of a class of uncertain strict-feedback systems subject to partial loss of actuator effectiveness, in addition to uncertain model dynamics and unknown disturbances. A resilient anti-disturbance dynamic surface control method is proposed to achieve stable tracking regardless of partial actuator faults. First, data-driven adaptive extended state observers are designed based on memory-based identifiers, such that the uncertain model dynamics, external disturbances, and the unknown input gains due to actuator faults can be estimated. Next, a resilient anti-disturbance dynamic surface controller is developed based on recovered information from the data-driven adaptive extended state observers. After that, it is proven that the cascade system formed by the observer and controller is input-to-state stable. Finally, comparative studies are performed to validate the efficacy of the resilient anti-disturbance dynamic surface control method for nonlinear strict-feedback systems subject to partial loss of actuator effectiveness.