bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Extract of Getih-Getihan (Rivina humilis L.) on Armyworm (Spodoptera litura F.) Mortality
Authors: Nurhayati Dewi , Subchan Wachju , Prihatin Jekti
Published: August 2019

Armyworm (Spodoptera litura F.) is a leaf-eating pest causes the loss of crops from 85% until causing crop failure. Alternative pest control and to reduce the negative impact of synthetic pesticides include using botanical pesticide. Getih-getihan plant (Rivina humilis L.) is one of the plants having potency as a botanical pesticide. Based on the description, this study was conducted to determine LC50 value by using probit analysis and analysis of an extract of Rivina humilis L. leaves on the mortality of Spodoptera litura F. using ANOVA test. Rivina humilis L. leaves are extracted by using ethanol solvent to get active chemical to kill Spodoptera litura F.. TLC (Thin Layer Chromatography) result test of an extract of Rivina humilis L. are positively contain an alkaloid, flavonoid, tannin, and terpenoid. The method of the research uses CRD (Complete Random Design) with five times repetition. Concentration serial being tested are 0%, 0.5%, 1%, 1.5%, 2%, and 2.5%. The result of probit analysis is 1.42% of LC50 value and ANOVA test shows that extract of Rivina humilis L. leaves affects very significantly on the Spodoptera litura F. mortality (p=0.000).

Keywords: Spodoptera litura F., Rivina humilis L., leaves extract.
Analysis of Student Ability to Develop ICT-Based Teaching Materials (Case Study in Biology Education Study Program UIN Syarif Hidayatullah Jakarta)
Authors: Susanti Baiq Hana
Published: August 2019

Global competitions require human resources that have competitive advantages, including in the field of education. UIN biology education program has responded by developing ICT-based lecture system. The development of the most up-to-date courses is e-learning, which is one of the learning system which use communication and information technology. Learning object becomes very important part. Students become accustomed to utilize the various learning sources available online. On the other hand, the ability to develop teaching materials is one of the required skill as professional teachers. The research purpose was to obtain more information about the ability of students to develop ICT-based teaching materials. This research used descriptive qualitative method, the assessment of teaching materials developed by students done before and after the lecture. The subject of research was the 25 students who were enrolled in Vertebrata courses. The validity of the teaching materials assessed by experts using specific instrument, students respond data also collected using questionnaire.The results showed that the average value given by the expert validators was 83 that fall into good category. While the average response of students to teaching materials fall into moderate category. Teaching materials developed by students before and after the lecture also showed significant changes. Before the lecture, all teaching materials developed by students are still in the form of power point. After attending lectures, the types of teaching materials developed by the students were varied. Those consist of wordpress (24%), wix (20%), webnode (12%), prezi (12%), android (8%), macromedia 3D Presentation, Power Point Inspiring, and Website UIN respectively by 4%.

Keywords: ICT-based learning materials, learning object, e-learning.
Development of Edmodo-Based E-Learning Media on the Plantae's Discussion for Learning Biological High School
Authors: . Ivaturrohmah , Mudakir Imam , Fikri Kamalia
Published: August 2019

Biology is a science whose concept is abstract and has a wide scope. One of them is the subject of Plantae that requires appropriate media to help to visualize the material being taught. Some things to consider in the selection of media such as material and learner characteristics. Characteristics of learners today is known as the Z generation so that the appropriate media is one that involves the use of technology. One of them is Edmodo-based e-learning media. The use of Edmodo-based e-learning media enables the delivery of more varied and much-involved students. This study aimed to find out the development process of Edmodo-based e-learning media and to produce a valid product as well as to know the effectiveness and practicality of the product. This research was a development research using a method by Borg and Gall (1983) model that has been modified by Sugiyono (2006). Stage of limited scale trial was conducted in SMAN 2 Jember and SMAN 4 Jember. The result of the product validation test of e-learning media development on average produced a valid product. Effectiveness test at SMAN 2 Jember and at SMAN 4 Jember resulted in a high N-Gain score. The result of the practicality test through the students and teachers responses of SMAN 2 Jember and SMAN 4 Jember created a response with strongly agree category.

 

Keywords: Edmodo, e-learning, development, Plantae subject.
PENGARUH EMPLOYEE ENGAGEMENT TERHADAP WORK-LIFE BALANCE KARYAWAN
Authors: Ariawaty R. Rina Novianty
Published: August 2019

A company’s objective to create employee engagement is to maintain the loyalty of its human resources. Employee engagement is directly related to the allocation of employee’s role and time inside and outside of their work environment as part of the work-life balance dimension. The purpose of this research is to analyze the effect of employee engagement on the employee’s work-life balance in the BRI Branch Office of Tanah Abang, Jakarta. The sample consisted of 39 employees collected by applying census sampling. Data were analyzed using PLS. The results indicated that employee engagement had a significant effect on employee work-life balance in the BRI Branch Office of Tanah Abang, Jakarta. This finding implies that employee’s work-life balance could be weakened or strengthen depends on the level of their engagement towards the company or organization.
Pengaruh Pendekatan Kontekstual dalam Motivasi Belajar Siswa Sekolah Menengah Pertama
Authors: Nurmawarni Sukma
Published: August 2019

This study has the aim of knowing students' understanding and motivation with the CTL approach. In the learning process is bound to the learning approach so that the learning process can run optimally, fun and full of meaning. In contextual learning students must connect knowledge through material provided by educators and connect with real life. Data collection was carried out by giving questionnaires to students' subjects from SMPN 1 Sukorambi. If you use the CTL method, students' memory will become strong and will not be forgotten.

 

Keywords: students, CTL, meaningful learning.
Mathematical Analysis Method for Stock Market Using MA and KDJ Indicator
Authors: Yuan Man
Published: August 2019

With the rapid development of Economic Globalization as well as international trade and capital transaction, stock market take a more and more important position in the finance analysis.In this thesis, I combined the MA the KDJ, MA for long term trend analysis and KDJ for short term analysis. First I introduced MA and KDJ separately, their strength and weakness. Then I try to put them together, adjust the parameters to make them suitable for Shanghai Stock Exchange Composite Index.Then I use my model to simulate transaction in real world, estimate the rate of return and comparing with the stocks’ holding rate and inflation rate. The result is pleasant. At last, I give a conclusion and a further advice to this model.
Priority Issues from a Health Implementation Plan: A Qualitative Study of Local Foundation and Nonprofit Leaders’ Perceptions
Authors: Schober Daniel John , Bowers Shannon M. E. , Posner Anne
Published: August 2019

The purpose of this article is to examine how local leaders of health foundations and nonprofit organizations perceive key health issues (such as violence, housing, and chronic disease) included in a municipal health department’s implementation plan. Specifically, we examine how these leaders prioritize health issues and what their ideas are regarding how to address them. To do this, we used a semistructured interviewing strategy to gather feedback from 10 senior leaders of health foundations and 13 senior leaders of nonprofit agencies in the City of Chicago. We conducted a content analysis of these interviews and found that participants emphasized the importance of addressing broad conditions related to violence, economic development, and education across the lifespan using multisector collaboration strategies. These findings suggest that these foundation and nonprofit representatives consider social determinants of health to be key in promoting population health.
Type 2 Diabetes Mellitus Increases The Risk of Late-Onset Alzheimer’s Disease: Obesity, Aging, Intersects and Continuum Of Progression
Authors: Hayden Melvin R.
Published: August 2019

Type 2 diabetes mellitus (T2DM) and late-onset Alzheimer’s disease-dementia (LOAD) have become parallel global pandemics and current predictions indicate they will only increase over the coming decades. These pandemics may result from the coexistent increase of obesity and aging. T2DM is associated with cognitive impairments associated with both metabolic factors, diabetic cognopathy (DC) and an increased risk of LOAD. This review addresses possible mechanisms due to obesity, aging, intersects and mechanisms for the continuum of progression. Multiple ultrastructural images in female diabetic db/db models are utilized to demonstrate marked cellular remodeling changes and provide for the discussion of functional changes in T2DM. Throughout this review multiple endeavors to demonstrate how T2DM increases the vulnerability of the brain’s neurovascular unit (NVU), neuroglia and neurons are presented. It is difficult to condense so many links between T2DM and LOAD; however, five major intersections could be considered: i. aging (chronic age-related diseases); ii. metabolic (hyperglycemia - advanced glycation end-products and its receptor (AGE/RAGE) interactions and hyperinsulinemia – insulin resistance (a linking linchpin); iii. oxidative stress (reactive oxygen-nitrogen species); iv. inflammation (peripheral macrophage and central brain microglia); v. vascular (macrovascular accelerated atherosclerosis - vascular stiffening and microvascular NVU remodeling with resulting impaired cerebral blood flow).
Enzymatic Hydrolyzed Potato Powder Stabilizes the Properties and Rheological Performance of Yogurt
Authors: Ahmad Ishtiaq , Xiong Zhouyi , Xiong Hanguo , Din Zia ud , Bakhsh Javaid Allah , Nawaz Asad , Walayata Noman
Published: August 2019

The current study emphasizes on optimizing a suitable ratio of enzymatically hydrolyzed potato powder (EHPP) and whole milk powder (WMP) to produce a quality yogurt by evaluating the physicochemical and rheological properties. The results showed that the addition of EHPP decreased the pH towards acidic conditions which resulted in the high acidity of yoghurt. The proximate composition showed that EHPP increased the ash, protein, water holding capacity (WHC) while fat, synersis, color parameters and total solid were decreased when compared to control yoghurt (CY) sample. Moreover, texture profile (TPA) analysis showed that the addition of EHPP decreased the hardness and cohesiveness while springiness did not show significant difference. Furthermore, rheological properties revealed that EHPP decreased the storage modulus (G’) and loss modulus (G”) when compared with control. In addition to this, sensory analysis revealed that the treatment P4M (1:3) was found as optimum ratio regarding taste, flavor, and aroma. Besides this, scanning electron microscopy (SEM) confirms that the high amount of EHPP resulted in the void holes while CY showed dense gel structure. The prepared yogurt with EHPP provides an excellent flavor, satisfying sweetness and homogeneous texture. These findings suggest the optimum formulation ratio of prepared yogurt was found to be P4M (1:3) for desirable attributes and consumer acceptance. The prepared yogurt from the EHPP presents the potential industrial applications.
Castanea sativa Mill. Shells Aqueous Extract Exhibits Anticancer Properties Inducing Cytotoxic and Pro-apoptotic Effects
Authors: Cacciola Nunzio Antonio , Squillaci Giuseppe , D’Apolito Mariella , Petillo Orsolina , Veraldi Francesco , La Cara Francesco , Peluso Gianfranco , Margarucci Sabrina , Morana Alessandra
Published: August 2019

In this study, bioactive compounds present in chestnut shells (CS) - derived from the industrial peeling processing - were extracted through different procedures. The aqueous extracts were characterized and the highest extraction yield and total phenolic content was obtained by Conventional Liquid Extraction (CLE). Gallic and protocatechuic acids were the main simple phenols in the extract with 86.97 and 11.20 mg/g chestnut shells dry extract (CSDE), respectively. Six tumor cell lines (DU 145, PC-3, LNCaP, MDA-MB-231, MCF-7 and Hep G2) and one normal prostate epithelial cell line (PNT2) were exposed to increasing concentration of CSDE (1-100 µg/mL) for 24 h and cell viability was evaluated using MTT assay. A reduced rate in cell viability was observed in DU 145, PC-3, LNCaP and MCF-7 cells while viability of MDA-MB-231 and Hep G2 cells was not affected except for PNT2 cells at a concentration of 100 µg/mL. Furthermore, CSDE-at concentrations of 55.5 and 100 µg/mL- lead to a significant increase of apoptotic cells in DU 145 cells of 28.2% and 61%, respectively. In conclusion, our findings showed that CS might be used for the extraction of several polyphenols that may represent good candidates for alternative therapies or in combination with current chemotherapeutics.
Effect of Tea Polyphenol on Serum Hormone, Serum Enzyme Activity and Antioxidant-Related Gene Expression in Chinese Yellow Chicken under Heat Stress
Authors: Yang Minxuan , Lu Yinglin , Zhu Qizhao , Gao Peng , Xie Xiaolei , Yu Debing
Published: August 2019

The present study was conducted to evaluate the effects of dietary supplementation of tea polyphenol （TP） on serum hormone, serum enzyme activity, antioxidant-related and immune-related gene expression of laying hens under heat stress. A total of 288 Chinese yellow chicken (186 days old) were randomly distributed among two treatments, each of which included 6 replicates of 24 hens. Dietary treatments were that the basal diet was supplemented with 200 mg / kg tea polyphenol. The study lasted for 7 weeks, including 1 week of adaptation and 6 weeks of the formal test. The content of high-density lipoprotein cholesterol (HDL-C) and total protein (TP) in serum significantly decreased by dietary supplementation with tea polyphenol. Dietary tea polyphenol supplementation improved serum superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) enzyme activity and decreased serum malondialdehyde (MDA) content in treatments compared to the control. However, supplementation of tea polyphenol did not affect the activity of serum catalase (CAT). The results indicated that long-term feeding of tea polyphenols help to increase the amount of hormones (FSH, E2) associated with reproduction in laying hens and thus improve egg production. It also improved the immune function of laying hens in high temperature environments. Adding tea polyphenols to the diet can significantly increase the serum IgG, IgM content of the laying hens and can upregulate the IgA content. Dietary supplementation of tea polyphenols in the laying hens significantly increased the expression of antioxidant enzyme-related genes (SOD, CAT and GPX1) in the liver. Moreover, the addition of tea polyphenols significantly increased the expression of immune-related genes (Interferon-γ (INF-γ), Interleukin 2 (IL-2) and Interleukin 4 (IL-4)) in the spleen. It is concluded that addition of tea polyphenols has a positive effect on antioxidant activity and immune function of laying hens.
KESIAPAN FUNGSI JALAN PERINTINS KEMERDEKAAN, PANDANARAN, NANGKA GUMULAN SETELAH ADANYA KANTOR PEMERINTAHAN TERPADU KABUPATEN BOYOLALI
Authors: Permatasari Citra ayu , Soedwiwahjono Soedwiwahjono , Nurhadi Kuswanto
Published: August 2019

Transportasi merupakan kebutuhan dasar manusia dalam melakukan aksesibilitas dan mobilitas. Untuk memenuhi kebutuhan manusia tersebut, dibutuhkan jalan sebagai fungsi utama dari sistem transportasi. Fenomena transportasi di Kabupaten Boyolali adalah Pemindahan Kantor Pemerintahan Terpadu Kabupaten Boyolali yang terletak di antara ruas Jalan Perintis Kemerdekaan, Jalan Pandanaran dan Jalan Nangka Gumulan. Isu pemindahan Kantor Pemerintahan nantinya akan berdampak pada meningkatnya arus lalu lintas. Oleh karena itu kesiapan fungsi jalan dapat diukur dari sistem jaringan jalan yang digunakan dalam melayani kebutuhan di kantor pemerintahan terpadu Kabupaten Boyolali. Tujuan dalam penelitian ini adalah untuk mengetahui kesiapan ruas Jalan Perintis Kemerdekaan, Pandanaran dan Nangka Gumulan setelah adanya Kantor Pemerintahan terpadu Kabupaten Boyolali dengan beberapa variabel penelitian diantaranya, (1) ketuntasan dalam pengembangan jaringan jalan, (2) tingkat pelayanan jalan, (3) ketersediaan moda transportasi, (4) ketersediaan lahan parkir, (5) fungsi sarana dan prasarana jalan, (6) tingkat fungsi lembaga. Penelitian ini merupakan penelitian kuantitatif dengan menggunakan teknik analisis deskriptif kuantitatif dan analisis skoring. Analisis skoring dilakukan pada masing-masing variabel penelitian. Hasil akhir yang diperoleh, bahwa ke tiga ruas jalan siap mendukung keberadaan Kantor Pemerintahan Terpadu Kabupaten Boyolali. Namun terdapat beberapa variabel penelitian yang masih memerlukan peningkatkan guna pengoptimalan fungsi jalan pada masing-masing ruas jalan. Salah satunya adanya rekayasa lalu lintas untuk mengoptimalkan fungsi jalan pada ruas Jalan Kantor Pemerintahan Terpadu Kabupaten Boyolali.

Kata kunci: Kesiapan, Sistem Jaringan Jalan, Sistem Kegiatan
IMPROVING THE COLLEGE STUDENTS’ SPEAKING SKILL OF POTENSI UTAMA UNIVERSITY THROUGH TOTAL PHYSICAL RESPONSE METHOD
Authors: Amaniarsih Dwi Suci , Firdaus Firdayanti
Published: August 2019

Abstract

 

The purpose of this study is to find out how the application of the Total Physical Response method in an effort to improve English language skill. The subjects in this study were the college students of Potensi Utama University in Medan. While the object of this research is the application of the TPR method, to improve students' skill to speak English. Based on the results of the study it can be seen that the percentage of the results of the completeness of the students' scores between the preliminary conditions and the first and the second cycle has increased. In the preliminary conditions the percentage of completeness in student grades is only 24%. In the first cycle, the percentage of completeness of students' scores increased to 40%, while in the second cycle there was a significant increase to 68%. If a comparison is made between students 'speaking abilities during the preliminary conditions and after the application of the TPR method, there is a 53% increase in students' English speaking skill using the TPR method. Thus it can be said that the use of the TPR method can improve students' English skill in the procedure text.

Keywords: Speaking skill, Total Physical Response method
Regression of Retro-odontoid Pseudotumor Using External Orthosis without Atlantoaxial Fusion
Authors: Nakazawa Toshiyuki , Inoue Gen , Imura Takayuki , Miyagi Masayuki , Saito Wataru , Shirasawa Eiki , Kawakubo Ayumu , Takaso Masashi
Published: August 2019

Case:

We treated an 87-year-old woman with noninflammatory retro-odontoid pseudotumor induced by atlantoaxial instability (AAI) using only a Philadelphia collar. Because of perioperative risk factors, fusion surgery was canceled; nevertheless, the neurological symptoms improved gradually. After 11 months of nonoperative treatment, the follow-up magnetic resonance imaging demonstrated that the pseudotumor's size was obviously diminished. Orthosis was applied for 2 years, and after its removal, the pseudotumor's size remained the same at the final 7-year follow-up.

Conclusions:

External orthosis is one treatment option for pseudotumor with AAI, especially in patients with significant comorbidities for whom surgical procedures are relatively contraindicated.
Acute Pesticide Poisoning amongst adolescent girls and women in Northern Tanzania
Authors: Lekei Elikana Eliona , Ngowi Aiwerasia V , Kapeleka Jones , London Leslie
Published: August 2019

Background: Acute pesticide poisoning (APP) is reported to affect community health worldwide but its burden in Tanzania is unknown particularly in women. This study examines APP involving adult females and adolescent girls 10 to 19 years in 3 regions of Tanzania which are famous for coffee and vegetable production Methods. A one year prospective study in 10 Tanzanian healthcare facilities was conducted using methods previous published by the same authors in 2014 Results. The study identified 108 APP cases of whom 31 (28.7%) occurred amongst adolescent girls. Suicide was the leading poisoning circumstances (60.2%) and the most vulnerable women were 20-29 years old who comprised 38.4% of all cases with suicide as circumstance. Organophosphates (OPs), zinc phosphide, paraquat and endosulfan were common amongst known reported poisoning agents. The annual APP incidence, mortality and Case Fatality Rate for women were 5.1/100,000, 0.2/100,000 and 3.7/100, respectively Conclusion. APP amongst women in Tanzania is common and this call for diverse preventive interventions to reduce poisoning incidents.
Effect of climatic factors on the seasonal fluctuation of human brucellosis in Yulin, Northern China
Authors: Liu Kun , Yang Zurong , Liang Weifeng , Guo Tianci , Long Yong , Shao Zhongjun
Published: August 2019

Background: Brucellosis is a serious public health problem primarily affecting livestock workers. The strong seasonality of the disease indicates that climatic factors may play important roles in the disease transmission. However, the associations between climatic variability and human brucellosis are still poorly understood. Methods: Data for a 14-year series of human brucellosis cases and seven climatic factors were collected in Yulin City from 2005 to 2018, one of the most endemic areas in northern China. Using the cross-correlation analysis, the Granger causality test, and the distributed lag non-linear model (DLNM), we assessed the quantitative relationships and exposure-lag-response effects between monthly climatic factors and human brucellosis. Results: A total of 7,103 cases of human brucellosis were reported from 2005 to 2018 in Yulin City with a distinct peak between April and July. Seasonal fluctuations in the transmission of human brucellosis were significantly affected by temperature, sunshine duration, and evaporation. The effects of climatic factors were non-linear over the 6-month period, and higher values of these factors usually increased disease incidence. The maximum separate relative risk (RR) was 1.36 (95% confidence interval (CI), 1.03–1.81) at a temperature of 17.4 °C, 1.12 (95% CI, 1.03–1.22) with 311 hours of sunshine, and 1.18 (95% CI, 0.94–1.48) with 314 mm of evaporation, respectively. In addition, the effects of these three climatic factors were cumulative, with the highest RR of 2.27 (95% CI, 1.09–4.57), 1.54 (95% CI, 1.10–2.18), and 1.27 (95% CI, 0.73–2.14), respectively. Conclusions: In Yulin, northern China, variations in climatic factors, especially temperature, sunshine duration, and evaporation, contributed significantly to seasonal fluctuations of human brucellosis within 6 months. The key determinants of brucellosis transmission and the identified complex associations are useful references for developing strategies to reduce disease burden.
TRANSPORTATION MANAGEMENT IN A DISTRIBUTED LOGISTIC CONSUMPTION SYSTEM UNDER UNCERTAINTY CONDITIONS
Authors: Raskin Lev , Sira Oksana , Karpenko Viacheslav
Published: August 2019

The problem of supply management in the supplier-to-consumer logistics transport system has been formed and solved. The novelty of the formulation of the problem consists in the integrated accounting of costs in the logistic system, which takes into account at the same time the cost of transporting products from suppliers to consumers, as well as the costs for each of the consumers to store the unsold product and losses due to possible shortages. The resulting optimization problem is no longer a standard linear programming problem. In addition, the work assumes that the solution of the problem should be sought taking into account the fact that the initial data of the problem are not deterministic. The analysis of traditional methods of describing the uncertainty of the source data. It is concluded that, given the rapidly changing conditions for the implementation of the delivery process in a distributed supplier-to-consumer system, it is advisable to move from a theoretical probability representation of the source data to their description in terms of fuzzy mathematics. At the same time, in particular, the fuzzy values of the demand for the delivered product for each consumer are determined by their membership functions.

Distribution of supplies in the system is described by solving a mathematical programming problem with a nonlinear objective function and a set of linear constraints of the transport type. In forming the criterion, a technology is used to transform the membership functions of fuzzy parameters of the problem to its theoretical probabilistic counterparts – density distribution of demand values. The task is reduced to finding for each consumer the value of the ordered product, minimizing the average total cost of storing the unrealized product and losses from the deficit. The initial problem is reduced to solving a set of integral equations solved, in general, numerically. It is shown that in particular, important for practice, particular cases, this solution is achieved analytically.

The paper states the insufficient adequacy of the traditionally used mathematical models for describing fuzzy parameters of the problem, in particular, the demand. Statistical processing of real data on demand shows that the parameters of the membership functions of the corresponding fuzzy numbers are themselves fuzzy numbers. Acceptable mathematical models of the corresponding fuzzy numbers are formulated in terms of bifuzzy mathematics. The relations describing the membership functions of the bifuzzy numbers are given. A formula is obtained for calculating the total losses to storage and from the deficit, taking into account the bifuzzy of demand. In this case, the initial task is reduced to finding the distribution of supplies, at which the maximum value of the total losses does not exceed the permissible value.
METHODS FOR FUZZY DEMAND ASSESSMENT FOR IT SPECIALTIES
Authors: Mammadovа Masuma
Published: August 2019

The rapid development of information technologies and their penetration into various spheres of human activity cause a sharply increased demand for IT specialists, in many countries of the world far exceeding the supply on them. High rates of technological transformation contribute to the diversification of the IT segment of the labor market, on the one hand, stimulate the disappearance of some and the emergence of new IT specialties, on the other. This creates a discrepancy between the structure of IT-related education and the labor market demand for IT specialists of the required profile and determines the relevance of developing methods for assessing the demand for IT specialties.

This article is devoted to the study and solution of the problem of identifying the demand for IT specialties in the absence of accurate and complete information about the situation in the IT market segment. For the assessment of IT specialties and their ranking by the degree of demand in the labor market, the tasks of making individual and group decisions in the context of fuzzy initial information are formulated and solved. The methodological basis of the tasks posed is multi-criteria decision support methods based on fuzzy relations of expert preferences.

The proposed approach as a mathematical tool for minimizing the structural imbalance of supply and demand for IT specialties is one of the components of the system of intellectual management of the labor market of IT specialists. The latter is designed to support the adoption of scientifically based management decisions to eliminate the mismatch of supply and demand in the IT segment of the labor market in professional, quantitative and qualitative sections.
METHOD OF PROTECTING SPECIALLY IMPORTANT OBJECTS BASED ON THE APPLICATION OF THE BISTATIC RADIOLOCATION TECHNIQUE
Authors: Kondratenko Aleksandr , Boikov Igor , Marenko Hennadii , Tsebriuk Ivan , Koval Oleksandr , Koval Andrii
Published: August 2019

The solution of the tasks assigned to the National Guard of the state implies the presence of certain forces and means with the appropriate technical equipment. A well-known place among such tasks is security of important state facilities. Various physical effects and methods, including radar, are used to create security systems.

The development of radar technology and technology made it possible to increase both the quantity and quality of the received information, as well as the use of radar stations for observing living objects.

The industry today produces bioradioradars for detecting people and controlling their movements. All samples are made in a single-position version and have a relatively high cost, the fact of their work is easily detected, which facilitates their suppression, including force.

In order to increase the secrecy of work, it is proposed to use the methods of separated, more precisely, bistatic location to control the area in front of particularly important objects.

The defining detection index is the effective reflective surface (ERS), which is about 1 m2 for a person. Equipment, weapons and protective equipment contributes to the increase in the ERS.

Given the small reflective surface of biological objects, it is proposed to limit the area of responsibility to the sector form in which, at a certain bistatic angle, the effect of a significant increase in the signal/(interference+noise) ratio is manifested. For a specific definition of the gain, it is necessary to choose the operating frequency of the bistatic system and its geometry.

For greater secrecy, it is advisable to use the transmitters of radio and television broadcasting, mobile communications, etc. The estimates found, for example, when using digital television transmitters (T2), indicate that the creation of a secretive bistatic system is quite possible – at least in a geometric interpretation.
DEVELOPMENT OF A POTENTIOMETRIC SENSOR SENSITIVE TO POLYSORBATE 20
Authors: Mironyak Maria , Volnyanska Olena , Labyak Oksana , Kovalenko Vadym , Kotok Valerii
Published: August 2019

Polyoxyethylated sorbitans (polysorbates) are widely used in the chemical, pharmaceutical, and cosmetic industries, but only quantitative determination is used mainly for chromatographic methods. In this paper, the results of the development and testing of a potentiometric sensor sensitive to nonionic surfactant polyoxyethylene sorbitan monolaurate (polysorbate-20) are presented. An anion of the heterogeneous acid of the Keggin structure (12-molybdophosphate heteropolyacid) was used as a counterion to obtain the electrode-active substance for the potentiometric sensor membrane. Polysorbate-20 does not form cations when dissociating in water and cannot directly interact with heteropolyanion; therefore, a cationic complex of polysorbate-20 with barium ions was previously prepared (similar to the interaction of metals with crown ethers). The resulting ion associate meets the basic requirement for the electrode-active substance of plasticized film polyvinyl chloride membranes of potentiometric sensors (poor water solubility and good solubility in organic solvents). Phthalic acid derivatives (dibutyl phthalate and dioctyl phthalate) were used as solvent-plasticizers for a polyvinyl chloride membrane. To determine the optimum conditions for the functioning of a potentiometric sensor sensitive to polysorbate-20, the influence of various factors on the electrode characteristics was studied. Quantitative content of the ionic associate in the polyvinyl chloride membrane, the nature of the membrane solvent-plasticizer, pH of a series of standard polysorbate-20 solutions) on the electrode characteristics of the plasticized membrane of the potentiometric sensor (sensitivity or slope of the electrode function, lower limit of linearity and minimum detectable concentration of polysorbate-20, which can be determined with the help of the developed potentiometric sensor) was studied. The optimal conditions for using the developed potentiometric sensor were found. The developed sensor allows for a short period of time (5–10 min) determining the quantitative content of polysorbate-20 in industrial products at the level 10–5–10‑6 mol/l. The potentiometric sensor sensitive to polysorbate-20 can be used for the development of a potentiometric method for determining the clinical reception of polysorbate-20 in various types of industrial products.
INVESTIGATION OF THE DYNAMIC LOADING OF A BODY OF PASSENGER CARS DURING TRANSPORTATION BY RAIL FERRY
Authors: Lovska Alyona , Fomin Oleksij , Horban Anatoliy , Radkevych Valentyna , Skok Pavel , Skliarenko Inna
Published: August 2019

To ensure the safety of passenger carriages by rail ferries, mathematical modeling of dynamic loading is performed. The accelerations are determined as components of the dynamic load acting on the body of a passenger car. This takes into account the actual hydrometeorological characteristics of the water area of the railway ferry. The calculations are made in relation to the railway ferry "Mukran", which moves the Baltic Sea. The model takes into account that the car body is rigidly fixed relative to the deck and during the oscillations of the railway ferry follows the trajectory of its movement. The solution of the mathematical model is implemented in the Mathcad software environment using the Runge-Kutta method. It is established that the maximum value of the acceleration acting on the car body is 1.8 m/s2.

Determination of the dynamic loading of the passenger car body during transportation by sea is also carried out by computer simulation. The calculations were carried out in the CosmosWorks software package using the finite element method. Numerical values and acceleration distribution fields are obtained relative to the carriage body structure of a passenger car.

A modal analysis of the car body during transportation by rail ferry is carried out. The numerical values of the critical frequencies and waveforms are obtained.

To check the adequacy of the developed models, a calculation is made according to the Fisher criterion. It is established that the hypothesis of adequacy is not rejected.

The research will contribute to the creation of recommendations on the safety of passenger carriages by railway ferries, as well as the manufacture of their modern structures in terms of car-building enterprises.
PECULIARITIES OF TLR-2 (ARG753GLN) AND TLR-4 (ASP299GLY) POLYMORPHISM PREVALENCE IN PATIENTS WITH ACUTE BRUCELLEIS AND CARDIOVASCULAR SYSTEM DISEASES
Authors: Huseynov Elchin Mammad oglu
Published: August 2019

Currently, there are single data on the relationship between TLR-2 polymorphisms (Arg753Gln) and TLR-4 (Asp299Gly) polymorphisms and susceptibility to brucellosis. Therefore, the aim of the study was to determine the frequency of TLR-2 (Arg753Gln) and TLR-4 (Asp299Gly) polymorphisms in patients with acute brucellosis with cardiovascular lesions in the Republic of Azerbaijan.

Materials and methods: 178 patients with a brucellosis clinic were examined. According to the criteria for inclusion in the study, only 120 people fully met all the criteria, which made up the main group. The control group consisted of 30 healthy individuals. TLR-2 (Arg753Gln) and TLR-4 (Asp299Gly) polymorphisms were also determined for all patients in both groups. In order to assess the state of the cardiovascular system, an electrocardiogram was recorded, blood pressure was measured, and an ultrasound scan of the heart was performed for all patients.

Results: it was found that 93 patients (77.50±3.13 %) with acute brucellosis had some or other signs of impairment in the work of the cardiovascular system, identified clinically or as a result of functional examination. Among carriers of the Asp / Gly genotype of the TLR-4 gene, an increased risk of brucellosis with CVS diseases was determined (χ2=30.19; p <0.0001; OR=24.29; 95 % CI [5.45 – 108.37]), while the carriage of the homozygous genotype Asp / Asp, by contrast, had a protective effect on the development of brucellosis (OR=0.06, 95 % CI [0.02 – 0.20]). Among the carriers of the Arg / Gln genotype and the Gln / Gln genotype of the TLR-2 gene, a significantly increased risk of brucellosis with CVS diseases was determined (χ2=5.68; p=0.02; OR=3.10; 95 % CI [0.99 – 9.67]) and (OR=2.48; 95 % CI [0.53 – 11.61]), respectively. While the carriage of the homozygous Arg / Arg genotype, by contrast, was rarely seen in patients with brucellosis (OR=0.28, 95 % CI [0.10 – 0.74]).

Conclusions: The Asp / Gly genotype of the TLR-4 gene was 12.7 times more frequently detected in patients with acute brucellosis with CVS diseases than in healthy individuals and 9.5 times more often than in patients without CVS diseases (p<0.05). The Arg / Gln genotype of the TLR-2 gene was 2.4 times more frequently detected in patients with acute brucellosis with CVS diseases than in healthy individuals (p<0.05).
STUDY OF MAIN QUALITY AND SAFETY PARAMETERS OF STRUCTURED OLIVES AND THEIR CHANGE UNDER THE INFLUENCE OF TECHNOLOGICAL FACTORS
Authors: Tishchenko Olga , Grynchenko Nataliya , Stepankova Galina , Pyvovarov Pavel
Published: August 2019

Today scientific-practical bases of technologies of structured food products allow to create a principally new segment of products at the food market. Introduction of new principles of processing raw materials and ingredients, practical production methods allows to get food products with a new commodity and consumption form.

There were studied technological aspects of producing structured food products of a round form on the example of the structured olive technology. Experimental studies and practical achievements in structuring (capsulation) allowed to create a product-analogue with quality and safety parameters, maximally approximated to the natural product. Principles of extruding formation with the synchronous combination of principles of external gel-creation allow to get a three-phase structure of a product (skin, internal content, filler), high organoleptic indices and target food value. At the same time the developed technology allows to involve in the technological process low-value parts of an olive-fruit and raw materials with decreased commodity-technological properties. In its turn, it allows to increase profitability indices and economic capacity of the new technology.
Genetic Parameters for Phenotypic Traits in Annual Ryegrass
Authors: Rios Esteban F. , Kenworthy Kevin E. , Gezan Salvador A. , Munoz Patricio R.
Published: August 2019

Characterizing phenotypes in germplasm collections and making data publicly available is crucial to ensure the utilization of the accessions in breeding programs. Variance component estimates are used to calculate genetic parameters needed to make strategic decisions for germplasm conservation and its utilization in plant breeding. This information is lacking for annual ryegrass (Lolium multiflorum Lamarck) germplasm from the USDA National Plant Germplasm System (NPGS). In this study, we estimated variance components, repeatability, genotypic values, genetic correlations, and genotype × year correlations for 18 traits in 167 annual ryegrass populations. Repeatability (H2) ranged from 0.11 to 0.93 for single‐year analyses, and from 0.03 to 0.86 for traits evaluated during two growing seasons, evidencing the presence of genetic variability. Genotype × year correlations ranged from 0.17 up to 0.99, demonstrating variable consistency in phenotypic performance across years. Combining multiple traits in one cultivar is a challenge for breeders, particularly for traits negatively correlated. Establishment, plant vigor, leaf width and length, and chlorophyll content were negatively correlated with disease traits. Heading date was positively correlated with number of tillers, crown size, and biomass production. High positive correlations were also found between biomass and plant height, crown size, tiller number and size, and leaf/stem ratio. The data presented in this study will become publicly available via the Germplasm Resource Information Network (GRIN)‐Global database of the NPGS.
Melting in the Fe-FeO system to 204 GPa: Implications for oxygen in Earth's core
Authors: Oka Kenta , Hirose Kei , Tagawa Shoh , Kidokoro Yuto , Nakajima Yoichi , Kuwayama Yasuhiro , Morard Guillaume , Coudurier Nicolas , Fiquet Guillaume
Published: August 2019

We performed melting experiments on Fe-O alloys up to 204 GPa and 3500 K in a diamond-anvil cell (DAC) and determined the liquidus phase relations in the Fe-FeO system based on textural and chemical characterizations of recovered samples. Liquid-liquid immiscibility was observed up to 29 GPa. Oxygen concentration in eutectic liquid increased from >8 wt% O at 44 GPa to 13 wt% at 204 GPa and is extrapolated to be about 15 wt% at the inner core boundary (ICB) conditions. These results support O-rich liquid core, although oxygen cannot be a single core light element. We estimated the range of possible liquid core compositions in Fe-O-Si-C-S and found that the upper bounds for silicon and carbon concentrations are constrained by the crystallization of dense inner core at the ICB.
Where is the 'Middle East'? : West-centric knowledge-power perception towards the ‘East’
Authors: KOÇ Mehmet Akif
Published: August 2019

Historically, all cultural, geographical and political names, descriptions, definitions etc. clearly reflect intense categorization, political prejudice, cultural bias, and in general ‘otherization’ to a certain extent. Orientalism, as an influential political-cultural tradition, unambiguously reveals discriminating and arrogant Western stance regarding the rest of the world, particularly the ‘East’ and the Islamic world. This general trend, as a mainstream tradition, can easily be observed within the context of historical Western approach towards the using of the term ‘Middle East’. This paper aims at reviewing the term of ‘Middle East’ as an outcome of the Orientalist perspective both in cultural and political terms, and emphasizes the importance of using alternative ‘regionalist’ terms and concepts to describe the region’s contemporary realities.
A 2D vertical model for simulating surface and subsurface flows using finite element–finite volume methods
Authors: Farrokhpour Leila , Namin Masoud Montazeri , Eskandari-Ghadi Morteza
Published: August 2019

A numerical model is presented for simulation of hydrodynamics of a 2D vertical free surface domain consisting of an arbitrary partitioned porous and non-porous area. To this end, modified Navier–Stokes equations are considered which could be applied in surface water and in subsurface flows, simultaneously. A wide range of Reynolds number has been considered, from which non-Darcy effects have also been taken into account. A fractional step method has been used in the time discretization procedure, where the convection and diffusion terms are separated from the pressure term while solving the momentum equations. To include the variation of surface elevation in computation, the domain has been divided into two parts, namely, ‘interior subdomain’, which never gets dry during the simulation period, covered by fixed unstructured triangular grids and ‘top layer’ with only a one layer structured grid, the position of which varies with the water surface. The validation of the proposed model has been achieved by comparison of its results with both theoretical and experimental data reported in the literature.
Accessing Public Compound Databases with KNIME
Authors: Hemmerich Jennifer , Gurinova Jana , Digles Daniela
Published: August 2019

Background:

The KNIME platform offers several tools for the analysis of chem- and pharmacoinformatics
data. Unless one has sufficient in-house data available for the analysis of interest, it is
necessary to fetch third party data into KNIME. Many data sources offer valuable data, but including
this data in a workflow is not always straightforward.

Objective:

Here we discuss different ways of accessing public data sources. We give an overview of
KNIME nodes for different sources, with references to available example workflows. For data sources
with no individual KNIME node available, we present a general approach of accessing a web interface
via KNIME.

:

In addition, we discuss necessary steps before the data can be analysed, such as data curation, chemical
standardisation and the merging of datasets.
Potential Role of Endonuclease Inhibition and Other Targets in the Treatment of Influenza
Authors: Szollosi Doreen , Bill Ashley
Published: August 2019

Background:

Influenza is a single-stranded RNA virus that is highly contagious and infects
millions of people in the U.S. annually. Due to complications, approximately 959,000 people were
hospitalized and another 79,400 people died during the 2017-2018 flu season. While the best methods
of prevention continue to be vaccination and hygiene, antiviral treatments may help reduce symptoms
for those who are infected. Until recently, the only antiviral drugs in use have been the neuraminidase
inhibitors: oseltamivir, zanamivir, and peramivir.

Objective:

We reviewed novel drug targets that can be used in the treatment of influenza, particularly
in the case of neuraminidase inhibitor-resistant strains that may emerge.

Results:

More recently, a drug with a new mechanism of action has been approved. Baloxavir marboxil
inhibits the influenza cap-dependent endonuclease that is needed for the virus to initiate replication
within the host cell. This endonuclease target is within the polymerase acid (PA) subunit of RNA
polymerase. Since the RNA-dependent RNA polymerase consists of two other subunits, polymerase
basic 1 and 2, RNA polymerase has several targets that prevent viral replication. Other targets still under
investigation include viral kinases, endocytosis, and viral fusion.

Conclusion:

Due to the possibility of viral mutations and resistance, it is important to have antivirals
with different mechanisms available, especially in the case of a new pandemic strain. Several novel
antivirals are within various stages of development and may represent new classes of treatments that
can reduce symptoms and complications in those patients who may be at higher risk.
Zebra Fish in Toxicology Research: Streptavidin Conjugated Peroxidase Assay in the Development Phase of Zebrafish Embryos to Study Liver Toxicities
Authors: Bala Asis , Mondal Chaitali , KantiHaldar Pallab
Published: August 2019

Background:

Zebrafish have similar hepatic anatomy and cellular architecture just like
mammals. Therefore, a number of investigators are using zebrafish to study liver pathologies. However,
the evaluation model specific to liver toxicities in zebra fish was not clearly stated earlier.
Aims and Objectives: The present study was designed to develop a model of embryonic liver toxicity
using dexamethasone (DEXA, 0-20 μM) as a standard hepatotoxic agent.

Methods:

such toxicities are easily measured by streptavidin-conjugated peroxidase assay after 48-
hour post-fertilization (hpf) of DEXA treatment.

Results:

In addition to morphological toxicities at different hpf, DEXA showed significant (*p<
0.05 &**p<0.01) reduction of peroxidase-chromogenic dye reaction in the assay as compared to
DEXA untreated embryos at 10 & 20 μM concentration that concluded the hepatocellular toxicity
of dexamethasone.

Conclusion:

Hopefully, the developed model for hepatotoxicity evaluation will be a promising
model for the evaluation of new drugs or chemicals as an easy vertebrate model before the commencement
of another animal model.