bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlation analysis of cancer incidence after pravastatin treatment
Authors: Yu Jin , Kim Raeun , Shinn Jiwon , Park Man Young , Kim Hun-Sung
Published: April 2023

Background: Few studies have investigated the cancer-preventive effects of statins, which are known to protect against cardio-cerebrovascular diseases. In this study, we analyzed the degree to which pravastatin, a low-potency statin, could prevent cancer.Methods: This retrospective cohort study used data from the Korean National Health Insurance Service database. Patients diagnosed with diabetes after the age of 50 years were divided into a pravastatin group and a control group that did not receive any statin prescriptions.Results: This study included 557 patients in the pravastatin group and 2,221 patients in the control (no statin) group. During the 5-year follow-up, the incidence of cancer was 16.7% (93 of 557 patients) in the pravastatin group and 19.9% (442 of 2,221 patients) in the control group. The incidence of cancer was 22% higher in the control group than in the pravastatin group (hazard ratio, 1.22; 95% confidence interval, 0.97–1.52; P=0.09). Death from various causes occurred at a 45% higher frequency in the control group than in the pravastatin group (hazard ratio, 1.45; 95% confidence interval, 0.99–2.12; P=0.06). However, neither of those relationships reached statistical significance.Conclusions: Although pravastatin use did not show a significant causal relationship with cancer incidence, fewer cases of cancer occurred in pravastatin users than in controls. However, further large-scale studies are required to confirm these findings.
CHARACTERIZATION OF PHENYLALANINE AMMONIA LYASE PURIFIED FROM LOCALLY CULTIVATED GRAPE SEEDS (Vitis vinifera L.)
Authors: S. Y. Hadeel  , S. A. Khalida
Published: April 2023

This study was conducted to investigate certain characteristics of the purified Phenylalanine ammonia lyase (PAL). The results revealed that the molecular weight was 180 kDa by gel filtration and Native-PAGE. The optimal pH and temperature for enzyme activity were 7 and 40 °C respectively. The enzyme activity was stable against pH values range of 6-8. The enzyme retained 79% of its total activity after incubation for one hour at 50 °C and retained 7% (lost 93%) of its activity at 70 °C. The entire activity was completely lost when the enzyme was incubated for 1 hour at temperatures over 70 °C. Carbohydrate content of the purified enzyme was estimated to be 24.61%. Km, Kcat and Vmax were estimated with phenylalanine as substrate, the values were 0.021 mM, 20.67 sec-1 and 4.13 mM/min respectively.
Simulation Studies of Social Systems – Telling the Story Based on Provenance Patterns
Authors: Reinhardt Oliver , Prike Toby , Hinsch Martin , Bijak Jakub , Wilsdorf Pia , Uhrmacher Adelinde M.
Published: April 2023

Social simulation studies are complex. They typically combine various sources of data and hypotheses, that are integrated by intertwined processes of model building, simulation experiment execution, and analysis. Various documentation approaches exist to support the transparency and traceability of complex social simulation studies. In particular, provenance patterns can be used to capture central activities and entities of a simulation study. Entities can include, simulation models, experiments, or research questions, and activities – model building, calibration, validation, and analysis. The exploitation of provenance standards enables information on sources and activities, which contribute to the generation of an entity, to be queryable and computationally accessible. In this study, we refine the provenance pattern-based approach to address specific challenges of social agent-based simulation studies. Specifically, we focus on the activities and entities involved in collecting and analyzing primary data about human decisions, and the collection and quality assessment of secondary data. We illustrate the potential of this approach by applying it to central activities and results of the Bayesian Agent-Based Population Studies project and by presenting its implementation in a web-based tool.
The Optimal Choice of Hypothesis Is the Weakest, Not the Shortest
Authors: Bennett Michael Timothy
Published: April 2023

Accepted for poster presentation at the 16th Conference on Artificial General Intelligence, taking place in Stockholm, 2023.

If A and B are sets such that A is a subset of B, generalisation may be understood as the inference from A of a hypothesis sufficient to construct B. One might infer any number of hypotheses from A, yet only some of those may generalise to B. How can one know which are likely to generalise? One strategy is to choose the shortest, equating the ability to compress information with the ability to generalise (a ``proxy for intelligence”). We examine this in the context of a mathematical formalism of enactive cognition. We show that compression is neither necessary nor sufficient to maximise performance (measured in terms of the probability of a hypothesis generalising). We formulate a proxy unrelated to length or simplicity, called weakness. We show that if tasks are uniformly distributed, then there is no choice of proxy that performs at least as well as weakness maximisation in all tasks while performing strictly better in at least one. In experiments comparing maximum weakness and minimum description length in the context of binary arithmetic, the former generalised at between 1.1 and 5 times the rate of the latter. We argue this demonstrates that weakness is a far better proxy, and explains why Deepmind's Apperception Engine is able to generalise effectively.
Scalable Addressing Circuits for a Surface Code Silicon-based Quantum Computer
Authors: Absar Rubaya , Merino Zach D. , Elgabra Hazem , Chen Xuesong , Baugh Jonathan , Wei Lan
Published: April 2023

A scalable circuit is designed to provide control signals for local and global operation of surface quantum error correction codes through a modular design of tiered switches controlled by demultiplexers. Critical power, performance, and area (PPA) merits are reported through a TSMC 65 nm technology implementation. The proposed design is an important step toward the implementation of scalable solid-state quantum processors with integrated cryo-electronics.
A Novel IoT-Enabled System for Real-Time Face Mask Recognition Based on Petri Nets
Authors: Shen Victor R.L.
Published: April 2023

Due to Coronavirus Disease 2019 (COVID-19), many countries have formulated pandemic prevention regulations, requiring the masses to wear a face mask before entering public places and taking public transportations. However, if the entrances of some places are manually checked to see whether people are wearing a face mask or not, it becomes not only labor-intensive and time-consuming, but also inefficiently checking each passer-by. Therefore, this paper aims to develop a face mask recognition system based on an edge computing platform. The traditional manual inspection control method is replaced by artificial intelligence (AI) technology to achieve automatic recognition and control. As an edge computing platform, Jetson Nano is an embedded system equipped with an AI platform, which can be used for object detection and image classification. Developed by Ultralytics LLC, a YOLOv5 model using the PyTorch framework runs on the edge computing platform, featuring high speed, high precision, and small size. According to the model training results, the average precision (AP) reaches 95.41%, while the mean average precision (mAP) records 94.42%. The average single-class running time is 0.016 seconds, and the file size of training model is 3.8MB. The recognition distance is up to 8m, and the maximum face rotation angle is 90°. In addition, a Petri net software tool, WoPeD, with graphical features based on mathematical theories, is used to verify the mask recognition system; and ensures the system has acceptable precision and recall values.
Task Space Outer-Loop Integrated DOB-Based Admittance Control of An Industrial Robot
Authors: Samuel Kangwagye , Haninger Kevin , Oboe Roberto , Oh Sehoon
Published: April 2023

Admittance control can improve robot performance and robustness in interactive tasks, but is still limited by stability when implemented on low-admittance hardware, such as position-controlled industrial robots. This limits applications which require the payload, reach, or positioning accuracy. While the idealized reference admittance behavior would be stable with any passive environment (provided positive damping), real robots can be unstable, especially with high-stiffness environments. Thus, instability comes from deviation from the ideal reference model, due to either inner-loop bandwidth, time-delay, or other model error.

To improve accuracy of rendered dynamics and reduce contact forces, a novel integrated disturbance observer-based admittance control method which is implemented on a position/velocity-controlled industrial robot in task space is proposed. The multisensor information, i.e., the velocity command, measured output velocity, inverse model of the velocity controlled system, and the force/torque (F/T) sensor measurement are integrated to estimate and cancel the disturbances, outside the position/velocity control loop, all in task space.

Theoretical analyses and experiments on the actual robot show that the proposed method is able to improve accuracy and reduce contact forces even at higher admittance.
Radar-based Human Activity Recognition: Is it Ready for Aging in Place?
Authors: Dey Ankita
Published: April 2023

With an increase in the population of older adults in developed nations globally, research on radar-based human activity recognition for reliable and accurate fall event detection has accelerated exponentially. Radars are safe, contactless, and privacy-preserving sensors that facilitate ‘aging in place’. A plethora of research papers have been published in this field in the last 5 years. The primary goal of all research works is to recognize the human activities from the backscattered radar returns. Despite being a well-researched field, technology-transfer from lab to market is implausible due to several underlying issues that are yet to be addressed. These issues will serve as a potential barrier when implementing the developed technologies in real-life. This article aims to reveal some of these issues that are important for successful technology-transfer of radar-based human activity recognition systems, and potential solutions to mitigate these issues are proposed.
Cultism in Higher Institutions in River State and its Implications for Educational Development (1960-2020)
Authors: Oroma Dr. Alikor , Godstime Dr. Orlunba Bartholomew
Published: April 2023

The menace of cultism has eaten deep into the Nigerian Institution of higher learning especially in Rivers State and inspite of the jail term for airing members of a cult group caught by the authorities as proscribed in the Nigerian 1999 constitution as amended. This menace is still growing and gaining more grounds in the entire higher institutions on daily basis. Cultism constitutes a major social problem to the peace and harmony that ought to exist within the academic confines of Rivers State. Admittedly the menace have attracted so much tension and concerns of major stakeholders within and outside the educational system and it negative impact affects our universities in terms of disruption of academic calendar, vandalization of school facilities, loss of lives of both innocent and actual cult members within and outside the school environs as well as raping of students. Unfortunately, it has been reported that students who are from disorganized family background that fall prey of joining cult group either in their local environment or when they gain admission into higher institution. This however, is now seen as a very big problem that need immediate solution if the aims and objectives of educating the younger generation are to be actualized. Thus, it further indicates that some factors that motivate the emergence and sustenance of secret cult in the educational system are traceable to the faculty decadence of our immediate society, the parental or student background, the educational environment etc. This study therefore offer some policy recommendations that is needed if we are ready to curtail the activities of cultism in our society and within our educational institutions in Rivers State.
Registration of Transfer of Land Rights in the Justice-Based Indonesian Legal System
Authors: Mashdurohatun Anis , Tambuno Arpa Syura , Wahyuningsih Sri Endah , R Mahmutarom, H.
Published: April 2023

The transfer of land rights is one of the events and/or legal actions which resulted in the transfer of land rights from the owner to the party other. The transition can be intentional due to legal actions such as: buying and selling, leasing and so on, and also not intentional because of this legal events such as the transfer of rights due to inheritance. This study aims to analyze the current construction of regulation on the registration of transfer of land rights, and find the Registration of Transfer of Land Rights in the Indonesian Legal System Based on the Value of Justice. This type of research is qualitative research. This research uses a social legal research approach. The type of data used is primary and secondary data. Data analysis was done through descriptive analysis. The results of the study found that the registration of the transfer of land rights in not guaranteeing legal certainty and based on the value of justice. This is influenced by the land registration system used in Indonesia in the form of a negative publication system with a positive tendency. In a negative registration system (negative system) with a positive tendency, the government does not provide guarantees for legal certainty for holders of legal evidence (certificates). The government is also not responsible for the data and information contained in land rights certificates. Data and information are considered correct as long as no other party is suing. So it is necessary to reconstruct the regulation of the transfer of land rights from a negative system to a positive system.
Diabetes and COVID 19: Experience of the Ibn Sina Hospital Rabat
Authors: Nawal Moussaid , Kaoutar El Moatamid , Manal Azriouil , Zainab El Mazouni , Kaoutar Rifai , Hinde Iraqi , Hassan Gharbi Mohamed El
Published: April 2023

Since the onset of the COVID-19 pandemic, it has become evident that individuals living with diabetes are at a heightened risk of experiencing severe forms of the disease. As such, a retrospective descriptive study was conducted in 236 diabetic patients who were admitted to the Ibn Sina hospital in Rabat due to COVID-19 infection. The study aimed to provide a comprehensive overview of the clinical, biological, radiological, and evolutionary parameters of diabetic patients infected with COVID-19. This article summarizes the results of the study and compares them with existing literature.
KNOWLEDGE MANAGEMENT AS A TOOL TO INCREASE THE ECONOMIC EFFICIENCY OF ENTERPRISES
Authors: CHAIKOVSKA Inna
Published: April 2023

The knowledge management system has a significant impact on the indicators of economic efficiency and competitiveness of the enterprise. To make an effective informed management decision in the field of knowledge management, it is necessary to identify and build models of the relationship between the complex indicator of the knowledge management system and the selected indicator of economic efficiency of the enterprise. The article analyzes the efficiency of utilities in the period 2015-2020. It is established that one of the main indicators of economic efficiency of the surveyed enterprises is labor productivity per employee. Models of dependence of enterprise productivity on the complex indicator of the enterprise knowledge management system (exponential, linear, logarithmic, polynomial, degree dependence) are represented. For each enterprise the optimal dependence model is chosen considering the value of the reliability of the approximation. The selected models allow to determine the required value of the complex indicator of the knowledge management system of the enterprise to achieve the target value of the productivity indicator. The article proposes the following possible scenarios of knowledge management: scenario "People", scenario "Technology", scenario "Learning", scenario " Innovative activity ", scenario "Innovation processes", scenario "Innovation cooperation", scenario "Operational activity" and scenario "Complex". Each of the scenarios reflects the individual threshold value of the complex indicator of the enterprise knowledge management system and, accordingly, labor productivity for each surveyed enterprise, as well as the corresponding level of costs. Depending on the level of the target value of the indicator of economic efficiency of activity, enterprises can choose one of the proposed scenarios of knowledge management.
Keywords: enterprise knowledge management, economic efficiency, labor productivity, economic-mathematical model, scenario.
Adoption of Human Resource Information Systems on Public Sectors in Tanzania
Authors: Ngulugulu Mathew Mgendu , Rwela Evelyne George , Mkwizu Noel Yoeza
Published: April 2023

Tanzania’s public sectors have begun to use Information Systems (IS) in various HR functions over the last fifteen years due to the increased use of Information and Communication Technology (ICT). Organisations are increasingly implementing Human Resource Information Systems (HRIS) to ensure that their human resources are used efficiently (HR). The purpose of this study is to investigate the functions and practices of the adoption of human resource information systems in Tanzania’s public sectors. The study areas were drawn from eight districts in the Mwanza region with the case study design accompanied by a mixed method technique. The population were 75 employees who were drawn from eight districts, yielding a sample size of 63 respondents. A non-probability sampling technique, known as purposive was employed to get relevant information from Human Resource Offices, ICT Officers, and Head of Departments from a sample size. The study employed survey questionnaires and interviews as methods for primary data collection and the self-administered questionnaires with closed-ended, 5-level Likert scale and semi-structured interview questions formats were used as tools for primary data collection. The study employed Statistics Package for Social Science (SPSS) to analyse descriptive and inferential Quantitative data and Atlas.ti to analyse the Qualitative data. The results of the study findings revealed that HRIS has been useful in eight districts in the Mwanza region in the management of human resources functions and practices and the study recommended that all public sectors in Tanzania should adopt HRIS to reduce the cost of HR operations.
Focused ultrasound for treatment of peripheral brain tumors
Authors: Johansen Phillip Mitchell , Hansen Payton Yerke , Mohamed Ali A. , Girshfeld Sarah J. , Feldmann Marc , Lucke-Wold Brandon
Published: April 2023

Malignant brain tumors are the leading cause of cancer-related death in children and remain a significant cause of morbidity and mortality throughout all demographics. Central nervous system (CNS) tumors are classically treated with surgical resection and radiotherapy in addition to adjuvant chemotherapy. However, the therapeutic efficacy of chemotherapeutic agents is limited due to the blood-brain barrier (BBB). Magnetic resonance guided focused ultrasound (MRgFUS) is a new and promising intervention for CNS tumors, which has shown success in preclinical trials. High-intensity focused ultrasound (HIFU) has the capacity to serve as a direct therapeutic agent in the form of thermoablation and mechanical destruction of the tumor. Low-intensity focused ultrasound (LIFU) has been shown to disrupt the BBB and enhance the uptake of therapeutic agents in the brain and CNS. The authors present a review of MRgFUS in the treatment of CNS tumors. This treatment method has shown promising results in preclinical trials including minimal adverse effects, increased infiltration of the therapeutic agents into the CNS, decreased tumor progression, and improved survival rates.
Cardioprotection by methylene Blue Against Epinephrine-Induced Cardiac Arrhythmias and Myocardial Injury
Authors: Abdel-Salam Omar M. E. , Sayed Marawan Abd El Baset Mohamed , Omara Enayat A , Sleem Amany A.
Published: April 2023

Methylene blue is used in the treatment of vasoplegic syndrome after cardiac surgery, anaphylaxis, and septic shock refractory to epinephrine and fluid resuscitation. In this study, we investigated the potential protective effect of methylene blue on the development of cardiac arrhythmias after injection of epinephrine in rats. Methylene blue was given intraperitoneally at doses of 50 or 100 mg/kg. Cardiac arrhythmia was then induced with 10 μg/kg of epinephrine intravenously. In untreated, control rats, epinephrine caused bradycardia (96.48 ± 1.06 vs. 365.03 ± 0.68 beats/min), increased PR interval (0.54 ± 0.04 vs. 0.039 ± 0.004), RR interval (0.64 ± 0.003 vs. 0.16 ± 0.004 sec), shortened QTc interval (0.067 ± 0.05 vs. 0.1 ± 0.004 sec), increased QRS duration (0.048 ± 0.005 vs. 0.028 ± 0.002 sec), decreased R wave amplitude (0.3 ± 0.03 vs. 0.49 ± 0.04 mv), decreased the height of the ST segment (-0.0696 ± 0.004 vs. -0.0054 ± 0.003 mv), and caused ventricular extrasystoles (7.92 ± 0.56 vs. 0.5 ± 0.5). Methylene blue given at 50 or 100 mg/kg increased the heart rate, decreased RR interval, QRS duration and the drop in the ST height, increased duration of QTc interval and R wave amplitude and decreased the number of extrasystoles. The histological study showed that methylene blue protected against myocardial structural disorganization, cellular damage, necrosis, and haemorrhage between muscle fibres induced by epinephrine injection. We conclude that methylene blue dose-dependently prevented epinephrine-induced arrhythmias and cardiac muscle injury.
Density of Scots Pine Wood in Drained Sphagnum Pine Forest
Authors:   Northern (Arctic) Federal University named after M.V. Lomonosov, Zagorodski Mikhail A. ,   Northern Research Institute of Forestry, Tretyakov Sergey V. , Koptev Sergey V.
Published: April 2023

The task of increasing forest productivity has been and remains one of the current interests of the European North of Russia, especially after the period of primary development of the forest areas. In the European Northeast, excessive humidity is observed at rather low average temperatures, which prevents active surface evaporation. In the twentieth century, the hydrotechnical reclamations were conducted on the large areas of swampy forests that increased the total productivity. The ecologists have an ambivalent attitude concerning forest draining. The supporters, who try to protect the undisturbed forest territories, counteract such activities. At the same time, the cultivation of highly productive forests of the right composition and quality requires measures for natural afforestation, or artificial forests must be created. Besides the total productivity of the stands, wood quality is an important factor in the hydroamelioration. It is mainly determined by density and the ratio between early and late wood. The influence of the landscape peculiarities of the drained forests on the quality of the wood was examined by the devotion of the areas according to the most typical groups of microrelief: flat areas, elevations, transitional areas. In cases of extensive humidity, the death of seedlings and artificial forest plantings was observed (soaking, frost extrusion, etc.). The creation of micro-elevations and the drainage of the excessive moisture guarantee the regeneration and establishment of the highly productive forests. The differences in the density of pine wood before and after the hydrotechnical reclamation were detected according to the landscape. The largest changes in the indicator were determined at the elevations and the flat areas, with the increase and the decrease, respectively. The trees that grow on the flat terrain after the reclamation show a relative excess of early wood over late wood, while at the elevations the presence of the late wood is predominant. For citation: Zagorodski M.A., Tretyakov S.V., Koptev S.V. Density of Scots Pine Wood in Drained Sphagnum Pine Forest. Lesnoy Zhurnal = Russian Forestry Journal, 2023, no. 2, pp. 160–171. (In Russ.). https://doi.org/10.37482/0536-1036-2023-2-160-171
The effects of opposition on collective and individual behaviours in soccer: A systematic review
Authors:   Universidade Federal de Viçosa, Machado Victor , Caríssimo João Marcelo , Teoldo Israel
Published: April 2023

Review question / Objective: This systematic review was conducted to verify the effects of opposition on different outcomes (e.g.: tactical, technical, physical and psychological dimensions) in colective (teams) and individual (players) behaviours on trainning sessions in soccer. Eligibility criteria: I)Articles wrote in English, Spanish or Portuguese; II) Articles published in peer-review journals; III) Articles with sample composed of soccer players of both genders (male and female).
I. S. Shmelev's Story ‘Candle’ and the Fate of Prince Golitsyn
Authors:   А.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Kaskina Yulia U.
Published: April 2023

The story “Candle” (1924) tells about a huge exemplary economy in the South of Russia, which name of Star-Novka is consonant with the Crimean Novy Svet, acquired in 1878 by Prince L.S. Golitsyn who created a winery in it. The fate of Star-Novka is described by Shmelev from the words of the Manager, who loved his business, but was forced to go abroad at the risk of his life after the establishment of Soviet power. However even in a foreign land he continues to believe in the undying humanity in people — the light in the soul, metaphorically manifested in the narrative by the image of a candle. The state of affairs of Prince Golitsyn, for 37 years skillfully and fruitfully managed the New World, gradually fell into decay, so that the estate in 1913 was donated to Nicholas II. L.S. Golitsyn died in 1915. His daughter and two granddaughters, underwent the troubles similar to those described in Shmelev's story. Thus, under the threat of execution in 1918, their jewelry was confiscated, in the 1920s their granddaughters were arrested, the husband of one of them managed to escape and settled in Paris. The real events he experienced, perhaps told and heard by Shmelev, could serve, in our opinion, a historical basis for the plot of the story “Candle”.
Z. N. Gippius and O. Mirtov (Olga Negreskul): Literary and Gender Parallels
Authors:   А.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Kaplun Marianna V.
Published: April 2023

In 1893, a story Apple Trees Are in Bloom by Z.N. Gippius was published in the journal Nashe vremya (Our Time). In 1911, a novel by O. Mirtov (pseudonym of the writer Olga Emmanuilovna Negreskul-Rosenfeld) under the same title Apple Trees Are in Bloom was published in the leading literary and political journal Russkaya Mysl’ (Russian Thought), edited by P.B. Struve. A close friend of the Merezhkovsky’s family, D.V. Philosophov in his 1914 essay The Feast Trunk pointed out the similarity of titles, reflecting on the secondary nature of literary and philosophical findings of Negreskul. An analysis of the Gippius’ story of 1893 and Mirtov’s novel of 1911 in the context of philosophical and gender ideas of the turn of the century makes it possible to speak of some literary parallels, both genetic and typological, characteristic of two female authors’ work, one of whom wrote under her own name, and the other worked under a pseudonym. The commonality of the plot arc of the two works, the similarity of philosophical and aesthetic statements, made in the spirit of modernist artistic quest, the proximity of the Negreskul to the symbolist picture of the world, as evidenced by her first literary experiments, make it possible to identify a common artistic concept of the formation of worldview and artistic motives in the work of two modernist writers.
MAPA GEOESTADÍSTICO DEL RUIDO AMBIENTAL PARA LA CIUDAD DE COBIJA: ESTUDIO DE CASO
Authors: Rivas Zenobio Mamani
Published: April 2023

El Plan de Gestión del Ruido Ambiental es fundamental, para conocer el comportamiento del ruido ambiental y definir las estrategias de control de la calidad del ruido ambiental en los 6 Distritos de la ciudad de Cobija; la investigación inicio con el monitoreo del ruido ambiental en 61 puntos, distribuidos de manera no probabilística, más al contario fue dirigida de acuerdo a las necesidades metodológicas y científicas. Para la obtención de los diferentes mapas se han empleado modelos de predicción geoestadística Kriging que permiten determinar el comportamiento de esta variable en lugares que no fueron monitoreados y proponer la línea base del ruido ambiental para el área urbana del municipio de Cobija. La ausencia de un plan de ordenamiento territorial en el municipio impulso a proponer una zonificación estratégica del ruido ambiental para el área de estudio. También se propone el límite de para el control de calidad del ruido ambiental de acuerdo a la zonificación, y como resultados se determinaron que alguno limites en diferentes áreas están por encima de los valores establecidos y propuestos en la presente investigación. En la investigación se pudo determinar que las avenidas principales como la 9 de Febrero, José Manuel Pando y 27 de Mayo, al igual que las zonas comerciales como Mercado Central, Mercado Abasto y la comercio, los valores encontrados son mayores a los límites establecidos en el Reglamento en Materia de Contaminación Atmosférica, como también en la zonificación propuesta. Por todo lo mencionado se puede concluir que el mapa de ruido ambiental marca la línea base, y es primordial realizar el ordenamiento territorial en las zonas mencionadas, ya que existen algunas Unidades Educativas que aparentemente estarían siendo afectadas por las emisiones sonoras, otra alternativa seria realizar el monitoreo constante en las zonas con mayores riesgos.
ARTÉRIA SUBCLÁVIA DIREITA ABERRANTE: RELATO DE CASO
Authors: Ribeiro Gabriel Manfredini de Barros , Tannous Juliana Marques , Ribeiro Ricardo de Barros , Rodrigues Rafael de Paula
Published: April 2023

Artéria subclávia direita aberrante é a anomalia mais comum da aorta e comumente descrita como tendo sua origem após a origem da artéria subclávia esquerda. A dificuldade de deglutição é o sintoma mais comum quando a artéria aberrante causa compressão do esôfago, normalmente, pela presença de aneurisma em sua porção proximal. Estudos alertam para o risco de lesões iatrogênicas e dificuldades em concluir exames de imagem durante procedimentos pré e perioperatórios em pacientes com artéria subclávia direita aberrante. A escolha pelo melhor manejo cirúrgico ainda é debatida e a decisão de intervir deve ser individualizada. Pacientes assintomáticos podem não necessitar de nenhuma intervenção, entretanto, devem ser acompanhados para o monitoramento de possíveis alterações no diâmetro do vaso aberrante. O presente estudo relata o caso de uma paciente com artéria subclávia direita aberrante e discute aspectos anatômicos e clínicos dessa anomalia congênita.
AFLUÊNCIA DA VEIA GONADAL DIREITA NA VEIA RENAL DIREITA
Authors: Araújo Moysés Macedo , Porto Ítalo de Souza , Silva Antônio Levi Alves , Almeida Francisco Emanuel Bezerra de , Maia Windeson Brenner Holanda , Oliveira Gabrielle Andrade de , Carvalho Matheus dos Santos , Lima Mateus de Paula , Cerqueira Gilberto Santos
Published: April 2023

Os vasos sanguíneos participam de todos os sistemas do corpo humano e podem variar em número, posição, irrigação e estrutura. Não obstante, a nefrologia e urologia, cada uma em sua especialidade, lidam de modo geral com a vascularização dos órgãos que lhes competem. Desse modo, o capítulo trata de um achado anatômico importante e atípico, encontrado no Anfiteatro de Anatomia de uma instituição de ensino superior localizada em Fortaleza, Ceará, o qual possui dados de que pouco mais de 1% dos casos estudados apresentaram essa variação além deste relato de experiência detalhando a peça anatômica encontrada. Ademais, é importante a discussão e a difusão desse conhecimento para o setor clínico cirúrgico, de forma a possibilitar que os profissionais tenham maior destreza em tratar desses pacientes e consigam taxas mais elevadas de sucesso operatório dos casos de nefrectomias, varizes pélvicas, varicocele e trombose da veia testicular direita.
CONFIGURAÇÃO DA ANATOMIA INTERNA DE PRÉ-MOLARES POR MEIO DE DIAFANIZAÇÃO
Authors: Oliveira Lucas Sabino , Lemos Ana Georgina Leite Matos de , Morais Ellen Soares de , Rocha Francisco Vinicius Teles , Peres Francisco Emanuel Andrade , Costa Neta Edith Pereira da Silva , Palombit Kelly , Guerra Sérgio Paulo Lima , Cardoso Arquimedes Cavalcante , Leite Carla Maria de Carvalho
Published: April 2023

Objetivo: Um dos requisitos essenciais no tratamento endodôntico é o entendimento da complexidade dos canais para o trabalho do cirurgião dentista. A falta de conhecimento da anatomia interna tem influência no sucesso do tratamento endodôntico, essa realidade se agrava ainda mais devido à complexidade das estruturas anatômicas destes dentes. Verificar a configuração do sistema de canais radiculares de pré-molares. Metodologia: Foi realizado o estudo in vitro da anatomia interna de 44 pré-molares, utilizando a técnica de descalcificação/diafanização associada com a injeção de tinta nanquim no interior da câmara pulpar. Resultados: Após análise dos resultados segundo a classificação de VERTUCCI, a maior incidência com 49,99% foi o Tipo V; seguido do Tipo II, com 45,44%; o Tipo IV, foi encontrado em 40,09% da amostra; também foram observados os Tipos II e III, em 27,26% cada; enquanto o Tipo VII só foi observado em 9,09% da amostra. Conclusões: Baseado na classificação proposta houve maior prevalência para o Tipo V, não sendo encontrado nenhum Tipo VI e VIII. Os resultados da pesquisa poderão identificar lacunas existentes, vindo complementar estudo sobre a temática.
UMA REVISÃO SOBRE AS PRINCIPAIS ALTERAÇÕES NEUROANATÔMICAS ENCONTRADAS EM INDIVÍDUOS COM TRANSTORNO DO ESPECTRO AUTISTA (TEA)
Authors: Santos LB , Martins LV , Oliveira MCS , Paffaro TA , Abreu BJ , Amaral EA
Published: April 2023

O autismo é um distúrbio do desenvolvimento neurobiológico que geralmente se manifesta antes dos três primeiros anos de vida, e que é reconhecido, atualmente, como Transtorno do Espectro Autista (TEA). Os indivíduos que apresentam TEA possuem alterações na socialização, na cognição e na comunicação. Embora não se conheça nenhuma alteração morfológica que seja determinante para o desenvolvimento do TEA, algumas alterações estruturais no encéfalo têm sido identificadas em indivíduos com o transtorno, dentre as quais vale ressaltar as mais recorrentes: alterações no volume cerebral total, nas dimensões do corpo caloso e no volume do cerebelo. Nesse sentido, o presente trabalho tem como objetivo abordar as alterações neuroanatômicas mais frequentes em indivíduos com TEA. Trata-se de uma revisão narrativa por meio de estratégia de busca nas bases de dados BVS, Google Acadêmico, Pubmed, ScienceDirect e Scielo, com inclusão das referências que possuíam disponibilidade de acesso ao texto completo. A análise da literatura indica que o aumento de volume cerebral total em indivíduos com TEA pode desencadear alterações funcionais na comunicação, embora tal acometimento se manifeste em diferentes graus e o desempenho em algumas tarefas seja essencialmente normal. Além disso, a diminuição no tamanho e no volume do corpo caloso possui relação com alguns défices comportamentais, motores e não-motores. Por sua vez, as alterações cerebelares podem determinar comprometimento comportamental, à medida que se relacionam com a disfunção sensorial observada no TEA.
MÚSCULO ARTICULAR DO JOELHO COM MÚLTIPLOS FEIXES MUSCULARES: RELATO DE CASO
Authors: Aragao José Aderval , Barros Junior Flavio de Souza , dos Santos Juliana Lima , Alarcon Mady Barbosa Maria Luiza , Nascimento Marcelo Diaz , Gomes de Souza Gladson , Prado Reis Francisco
Published: April 2023

O músculo articular do joelho é um pequeno músculo que se estende da face anterior da diáfise femoral até a bolsa suprapatelar. A incidência e a quantidade de feixes musculares que formam o músculo varia de 1 a 7 feixes. O presente trabalho é um relato de caso de um músculo articular do joelho com quatro feixes musculares. Todos os feixes tinham inserção proximal no terço distal do fêmur e a inserção distal na cápsula articular acima da bolsa suprapatelar, com exceção do feixe intermédio medial. O conhecimento anatômico desta variação seria relevante não só para os anatomistas, mas também para os cirurgiões nas ressecções de tumores ósseos.
ESPONDILITE ANQUILOSANTE EM VÉRTEBRAS LOMBOSSACRAIS: RELATO DE CASO
Authors: Brockmann Carolina , Rosa Davi , Petrica Gabriel , Gomes Thaís , Cezar Vitória , Isaac Andréia , Segat Laura , Pereira Kleber
Published: April 2023

A Espondilite Anquilosante (EA), popularmente conhecida como coluna em bambu, é uma doença inflamatória progressiva, de caráter autoimune, crônica, com forte correlação genética, caracterizada pela inflamação articular que pode resultar na calcificação patológica permanente que abrange os discos intervertebrais, causando uma fusão de vértebras, de modo que o movimento do indivíduo torna-se limitado, prejudicando sua qualidade de vida. O objetivo desse estudo foi relatar um achado anatômico lombossacral, encontrado em esqueletos humanos do laboratório de Anatomia da Universidade Federal do Paraná (UFPR), campus Toledo. Foram analisadas 18 ossadas provenientes do Cemitério Municipal de Cascavel-PR, preparadas através de osteotécnica. Entre essas peças, uma apresentou calcificação em sindesmófitos marginais simétricos entre a última vértebra torácica, as 5 vértebras lombares e o sacro, com aparente retificação do ângulo da lordose em relação à média, que corrobora EA. Essa doença, comumente ligada a presença do gene HLA-B27, acomete cerca de 1% da população, sendo mais prevalente em homens de descendência caucasiana entre 20 e 40 anos. Os primeiros sintomas incluem: dor e rigidez lombar, principalmente pela manhã e após períodos de inatividade. Embora o acometimento axial seja predominante, articulações periféricas também podem ser afetadas. A disseminação de informações pertinentes é fundamental para o diagnóstico precoce, melhorando significativamente o prognóstico, aprimorando a movimentação por fisioterapia, restabelecendo realização de tarefas e qualidade de vida do indivíduo, amenizando substancialmente a progressão da doença, ao diminuir a reação autoimune com utilização de fármacos. O achado exemplifica a alteração física mais frequentemente associada na EA e reforça a importância do estudo da anatomia para a melhor compreensão dos efeitos de dessa e os impactos sobre a vida de seus portadores.
APÊNDICE VERMIFORME SUB-HEPÁTICO
Authors: Aragão José Aderval , Batalha Filho Airton Lima , Santana Trindade João Gabriel , Sant’Anna Aragão Iapunira Catarina , Sant’Anna Aragão Felipe Matheus , Rocha de Almeida João Victor , Siqueira Kuhn Caio , de Carvalho Barros Lucimário , Lourenço Bárbara Costa , Prado Reis Francisco
Published: April 2023

Uma discussão recorrente na literatura é que trata a respeito da localização do apêndice vermiforme. Para tanto, há na literatura várias descrições e classificações. Enquanto era realizada uma dissecção anatômica de rotina, encontramos em um feto masculino um apêndice vermiforme localizado abaixo da face visceral do fígado, entre o ligamento redondo do fígado e a vesícula biliar. Este achado vem reforçar a atenção que deve ser dirigida às variações do apêndice, em especial para cirurgiões e aqueles profissionais que trabalham em urgência médica.
Variações Anatômicas: o avanço da ciência no Brasil
Authors: Aragão José Aderval
Published: April 2023

Esta obra constituiu-se a partir de um processo colaborativo entre professores, estudantes e pesquisadores que se destacaram e qualificaram as discussões neste espaço formativo. Resulta, também, de movimentos interinstitucionais e de ações de incentivo à pesquisa que congregam pesquisadores das mais diversas áreas do conhecimento anatômico de diferentes Instituições de Ensino Superior, seja públicas e privadas, de abrangência nacional e internacional. Tem como objetivo integrar ações interinstitucionais nacionais e internacionais com redes de pesquisa que tenham a finalidade de fomentar a formação continuada dos profissionais da área de saúde, por meio da produção e socialização de conhecimentos anatômicos nas diversas áreas dos saberes.
Agradecemos aos autores pelo empenho, disponibilidade e dedicação para o desenvolvimento e conclusão dessa obra. Esperamos também que esta obra sirva de instrumento didático-pedagógico para estudantes, professores dos diversos níveis de ensino em seus trabalhos e demais interessados pela temática.
AGILITY IN MARKETING: A BIBLIOMETRIC ANALYSIS
Authors: Thümler Nico
Published: April 2023

Research on agility in marketing has been shaped by a great number of articles published in recent decades. My research contributes to the literature by examining the basis of different intellectual frameworks and by identifying relevant references, authors, topics, and journals for the matter. With this focus, I used bibliometric techniques to investigate over 1,200 articles published between 1992 and 2022. I regarded publication periods that shaped the progression of the research subject. Results show that there are 75 relevant publications. Those could be divided into three research streams. The first stream considers frameworks and agile supply chains, the second IT infrastructure to improve enterprise agility, and the third enterprise and organizational agility in general. I applied a historical perspective, identified the social, intellectual, and conceptual structure of marketing agility research.
How Ram Pressure Drives Radial Gas Motions in the Surviving Disk
Authors: Akerman Nina , Tonnesen Stephanie , Poggianti Bianca Maria , Smith Rory , Marasco Antonino
Published: April 2023

Galaxy evolution can be dramatically affected by the environment, especially by the dense environment of a galaxy cluster. Recent observational studies show that massive galaxies undergoing strong ram-pressure stripping (RPS) have an enhanced frequency of nuclear activity. We investigate this topic using a suite of wind-tunnel hydrodynamical simulations of a massive M
star = 1011
M
⊙ disk galaxy with 39 pc resolution and including star formation and stellar feedback. We find that RPS increases the inflow of gas to the galaxy center regardless of the wind impact angle. This increase is driven by the mixing of interstellar and nonrotating intracluster media at all wind angles, and by increased torque on the inner disk gas, mainly from local pressure gradients when the intracluster medium (ICM) wind has an edge-on component. In turn, the strong pressure torques are driven by rising ram pressure. We estimate the black hole (BH) accretion using Bondi–Hoyle and torque models, and compare it with the mass flux in the central 140 pc region. We find that the torque model predicts much less accretion onto the BH of a RPS galaxy than the Bondi–Hoyle estimator. We argue that both models are incomplete: the commonly used torque model does not account for torques caused by the gas distribution or local pressure gradients, while the Bondi–Hoyle estimator depends on the sound speed of the hot gas, which includes the ICM in stripped galaxies. An estimator that accounts for this missing physics is required to capture BH accretion in a RPS galaxy.
Asteroseismic Determination of Stellar Rotation: On Synchronization in the Close Eclipsing Binaries AB Cas and OO Dra
Authors: Kim Seung-Lee
Published: April 2023

A star’s rotation rate is difficult to estimate without surface inhomogeneities such as dark or bright spots. This paper presents asteroseismic results to determine the rotation rates of δ Sct-type pulsating primary stars in two eclipsing binary systems, AB Cas and OO Dra. After removing the binarity-induced light variations from archival TESS data and carefully examining the combination frequencies, we identified 12 independent frequencies for AB Cas and 11 frequencies for OO Dra, with amplitudes higher than ∼0.3 mmag, as δ Sct-type pulsation frequencies excited in each primary star. The theoretical frequencies for seismic analysis were obtained by fully considering rotation effects. Grid fitting for various stellar properties, such as mass, radius, metallicity, and rotation rate, yielded the best solutions for which the theoretical frequencies and stellar parameters agreed well with the observations. The rotation rate of the AB Cas primary was tightly constrained to 0.81 ± 0.01 day−1 (f
rot/f
orb =

1.11

−
0.02

+
0.01

), which is slightly faster than the synchronized rotation. In contrast, the rotation rate of 0.63 ± 0.01 day−1 for the OO Dra primary is lower than the synchronous value of approximately 0.81 day−1. Subsynchronous rotation is uncommon in short-period binaries, and its physical mechanism is not yet well understood. Our results show that asteroseismology can be used to measure the rotation rate of fast-rotating δ Sct stars precisely and thus provide a valuable constraint on rotation–orbit synchronization in close binary systems.
CTLA4-Ig protects tacrolimus-induced oxidative stress via inhibiting the AKT/FOXO3 signaling pathway in rats
Authors: Jin Long , Shen Nan , Wen Xinyu , Wang Weidong , Lim Sun Woo , Yang Chul Woo
Published: April 2023

Background/Aims: Although the conversion from tacrolimus (TAC) to cytotoxic T-lymphocyte-associated antigen 4-immunoglobulin (CTLA4-Ig) is effective in reducing TAC-induced nephrotoxicity, it remains unclear whether CTLA4-Ig has a direct effect on TAC-induced renal injury. In this study, we evaluated the effects of CTLA4-Ig on TAC-induced renal injury in terms of oxidative stress.Methods: In vitro study was performed to assess the effect of CTLA4-Ig on TAC-induced cell death, reactive oxygen species (ROS), apoptosis, and the protein kinase B (AKT)/forkhead transcription factor (FOXO) 3 pathway in human kidney 2 cells. In the in vivo study, the effect of CTLA4-Ig on TAC-induced renal injury was evaluated using renal function, histopathology, markers of oxidative stress (8-hydroxy-2’-deoxyguanosine) and metabolites (4-hydroxy-2-hexenal, catalase, glutathione S-transferase, and glutathione reductase), and activation of the AKT/FOXO3 pathway with insulin-like growth factor 1 (IGF-1).Results: CTLA4-Ig significantly decreased cell death, ROS, and apoptosis caused by TAC. TAC treatment increased apoptotic cell death and apoptosis-related proteins (increased Bcl-2-associated X protein and caspase-3 and decreased Bcl-2), but it was reversed by CTLA4-Ig treatment. The activation of p-AKT and p-FOXO3 by TAC decreased with CTLA4-Ig treatment. TAC-induced renal dysfunction and oxidative marker levels were significantly improved by CTLA4-Ig in vivo. Concomitant IGF-1 treatment abolished the effects of CTLA4-Ig.Conclusions: CTLA4-Ig has a direct protective effect on TAC-induced renal injury via the inhibition of AKT/FOXO3 pathway.
Autour d’un tableau méconnu du Louvre : Bertholet Flémal, François Chauveau, Sébastien Leclerc, trois artistes pour un commanditaire à l’heure de la révocation de l’édit de Nantes.
Authors: le Pas de Sécheval Anne
Published: April 2023

Anne le Pas de Sécheval est maître de conférences à l’Université Paris Nanterre. Sa recherche est actuellement centrée sur la peinture dans les églises de Paris et l’art religieux en France au xvii e siècle. Elle a publié en 2018 « Hardouin-Mansart et la genèse du décor intérieur du Dôme » dans l’ouvrage Saint-Louis-des-Invalides : la cathédrale des armées françaises dirigé par Alexandre Gady et Antoine de Romanet. Paraîtra en 2020 l’article « Philippe de Champaigne et Charles Le Brun lecteurs du livre d’Ézéchiel ? Réflexions sur la culture biblique des peintres au xvii e siècle » dans les actes du colloque international Mise(s) en œuvre (s) des Écritures 2 de l’École des Chartes. Université Paris Nanterre, 200, avenue de la République, 92001 Nanterre Cedex.