bluuebunny/crossref_metadata_2025 huggingface dataset:
Explosion of Excess Stock Ammunition. The Impact on the Health of the Civil Community and the Army.
Authors: Nikollari Luan , Bejleri Adriana , Vasha Dorela , Dogjani Agron
Published: January 2019

Albania, like all the former communist countries, has inherited in 50 years a large arsenal of weapons and ammunition stockpiles, as shells and projectiles of various calibers, which constituted a negative phenomenon and seriously jeopardized the lives of people and communities throughout the geography of their deployment. After the 1990s, the Albanian Armed Forces embarked on the path of transformation and integration of Albania into NATO. In this framework, the implementation of defense reforms aimed the reduction and modernization of the military. In this context, one of the transformation goals was the getting rid of the remaining excess ammunition that was being destroyed under the programs of the Ministry of Defense and partner countries and the role of the University Hospital of Trauma and the Military Hospital in Tirana, Albania. This paper aims to discuss the security threat that these stockpiles pose to our nation and the wiser region. It also explains how the excess munitions eliminating process was completed in Albania.
Acute Traumatic Pericardial Tamponade.
Authors: Kuçi Saimir , Bulku Esmerilda , Ibrahimi Alfred , Bejko Ervin , Llazo Stavri , Burimi Jonela , Likaj Ermal
Published: January 2019

Acute traumatic pericardial tamponade is a serious and rapidly fatal injury. As penetrating chest wounds are becoming more cammon, early diagnosis of tamponade is important so that life savingtreatement can be started. The classical features of tamponade may a be modified by hypovolemia and the presence of associated injuries. Acute tamponade may also be precipitated by rapid administration of large volumes of fluid. Echocardiography is limited by availability and operator dependence. Pericardiocentesis, while sometimes life saving is dangereous and limited value. A higher deagree of clinical suspincion in patients with chest injuries, together with close monitoring and revaluation, particulary during volume remplancement is essential. This paper describes one patient presented to the emergency department of University Hospital Center “Mother Theresa “ and it discusses the epidemiology and management principles of acute tamponade.
Surgical approach on Reccurent Retroperitoneal Liposarcoma with Involvement of Surrounding Organs
Authors: Selmani Rexhep , Karadzov Zoran , Begovic Goran , Rushiti Qemal , Vrgovic Nenad , Gogovski Dejan , Domazetovski Darko
Published: January 2019

Background: Retroperitoneal sarcomas are neoplasm that are only 0,3-3% of all solid tumors. Liposarcomas is most freguent soft tissue sarcomas in adults. Symptoms would only be detected if the liposarcoma presses on the surrounding organs.

Case presentation:  A 58-year-old woman presented with complaint of progressive abdominal distension, loss of appetite, malaise, constipation and weight loss of about 7 kg. Abdominal CT scanning showed the presence of a retroperitoneal tumor that occupies almost the entire right part of abdominal cavity. 16 months earlier, the patient was operated in another surgical facility due to liposarcom, derived from retroperitoneum (Histopathological finding: Poorly differentiated (G3) liposarcoma pleomorphic cell type). The patient was operated under the diagnosis of retroperitoneal liposarcoma.

Conclusions: Treatment of choice is radical surgical procedure including elimination of all the structures and organs involved by the tumour process - RO resection as a basic principle of surgical treatment.
Gastrointestinal Complications Following Cardiac Surgery.
Authors: Ibrahimi Alfred , Kuçi Saimir , Bejko Ervin , Llazo Stavri , Burimi Jonela , Bulku Esmerilda
Published: January 2019

Purpose: gastrointestinal complication (GIC) following open heart surgery usually are rare but with high morbidity and mortality. The aim of this study was to see the outcome of these patients after complication, compared with a similar study found in literature. Identifying risk factors preoperatively and postoperatively in our patient’s series, for GIC.Materials and methods: Between January 2012 and December 2017 from 1990 operated cardiac patient 34 of them developed GIC, presenting gastro duodenal bleeding due to active ulcer, liver failure, pancreatitis, cholecystitis, or intestinal ischemia. We performed a retrospective analysis.Results: From all consecutive patient only 1.7 % developed GIC. Mortality rate was 55.8%, especially 100 % mortality in intestinal ischemia patient. Regarding risk factors, those were the same found in other similar study (age, atherosclerosis disease, by pass time, postoperative ARF, Low cardiac output syndrome.)Conclusion: GIC after cardiac surgery are rare but when it happens the mortality is very high not even of late diagnosis. In ages patients, diabetes, long by pass time, long hypoperfusion state. It is recommended to be alert for GIC for detection in early phase, and for reducing as much as possible morbidity and mortality.
Effects of Octreotide and Allopurinol on Liver Histology and Functions in Surgical Jaundice: An Experimental Study
Authors: Ekinci Özgür , Eren Tunç , Gapbarov Aman , Gacemer Mert , Ozkinet Tulay , Çelik Faik
Published: January 2019

Aim: Mechanical jaundice may lead to adverse metabolic effects in surgical patients. Our aim was to investigate the effects of octreotid and allopurinol on liver histology and functions in rats with experimantally created mechanical jaundice.

Methods: The subjects were divided into five main groups. The rats in Group I (Control) received no interventions. In Group II, common bile duct ligation (CBDL) was performed. In Group III, the same ligation procedure was performed followed by the administration of octreotid. In Group IV, the rats received allopurinol following CBDL and in Group V (Sham), the common bile duct was dissected and left intact. After sacrification of each rat on the seventh postoperative day, blood samples were collected for serum hematocrit, direct bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), amylase, and albumin measurements in addition to the histopathologic examinations of the collected tissue specimens from the liver, terminal ileum, and pancreas. According to statistical analysis, a value of p<0.05 was considered as significant.

Results: The direct bilirubin, AST and ALT levels were detected to be significantly elevated in the groups II, III and IV, in which CBDL was performed (p<0.05). While significant reductions of serum direct bilirubin, AST and ALT levels were detected in the octreotide group, these parameters were significantly elevated in the allopurinol group (p<0.05 and p<0.05, respectively). There was no significant difference of hematocrit and albumine levels among the study groups (p>0.05). Additionally, in the allopurinol group four rats were found to have increased serum amylase levels and the histopathologic evaluations of their pancreatic samples revealed findings of pancreatitis. According to the histopathologic examinations, significant alterations were detected between the control and sham groups (groups I, V) and the CBDL groups (groups II, III, IV). However, these histopathological findings revealed no significant differences within the subgroup of subjects including CBDL alone (Group II), and CBDL along with the administration of either octreotide (Group III), or allopurinol (Group IV).

Conclusion: The use of octreotide in mehanical jaundice may have protective metabolic effects. Further studies are considered necessary to be carried to support these findings.
Surgical Treatment of Radial Head Fractures: Review of Literature.
Authors: Selmani Edvin , Dogjani Agron
Published: January 2019

The aim of this systematic review was to search for and critically appraise articles directly comparing functional outcomes and complications for fixation (ORIF) versus arthroplasty for comminuted radial head fractures (Mason type 3) in adults.

Material and methods: A comprehensive study of Medline, Embase and Cochrane databases using specific search terms and limits was conducted. Strict eligibility criteria were applied to stringently screen resultant articles. Three comparative studies were identified and reviewed.

Results: Two studies found significantly better functional scores after replacement compared with ORIF in Mason type 3 fractures. The third study found no significant differences in functional score or range of motion, but did find that grip strength was better after ORIF. Complication rates were too heterogenous for conclusion.

Conclusion: Fixation with good reduction may be attempted in unstable Mason type 3 fractures, and arthroplasty may be considered if this is not possible. Further randomised comparative trials are required to clarify the decision-making between fixation and replacement. Functional outcomes and complications were conflicting in the studies included here. Ideally, treatment decision should take into account elbow stability and degree of comminution.
Ethnoreligia as a scientific concept: the definitions of "knowledge" and "faith", "natural" and "supernatural"
Authors: Lozko G. S.
Published: January 2019

Religion is a phenomenon of the spiritual life of mankind, its world-view basis, which regulates the daily life and behavior of man, and also allows communication with the "supernatural" (the Supreme Mind, the Absolute God) through the rites.The overwhelming majority of definitions of the religious phenomenon relies mainly on two categories of religious studies: "supernatural" and "faith." For example, religion is defined as: "a spiritual phenomenon, which expresses not only the belief in the existence of a supernatural Beginning, which is the source of existence of all existing, but also acts as a means of communicating with him, entering into his world."
Religious and philosophical system "Ise monogatari zui"
Authors: Kapranov S. V.
Published: January 2019

Richard Browring called "Isi monogatari" one of the most important and at the same time one of the most mysterious texts of Japanese culture. Created at the beginning of the tenth century, at a turning point, at the dawn of the early and mature phases of Hayan's days, this work was one of the first written in classical Japanese, one of the first works of the genre of monogatari, the first work of the genre Uta-monogatari, and others like that. He then laid down standards for the entire development of the Japanese literary tradition. However, we are not interested in the philological aspect of the problem (well-studied by both Japanese and foreign researchers), and such an aspect that was still on the periphery of the studios "Isi monogatari", namely, the religious and philosophical interpretation of the work. A vivid example of such an interpretation is one of the most ancient commentary on this work, "Isa monogatari zuiṇo:" ("The essence of Isa monogatari"). Next, for convenience, we will call it just "Zuino"
The doctrine of Vyacheslav Lipinsky about religious ideology in the context of religious studies of the era of Ukrainian national renaissance
Authors: Kondratyk Leonid
Published: January 2019

An important place in the religious studies concept of the outstanding Ukrainian scientist and social thinker V.Lipinsky (1882-1931) is the problem of the formation of religious ideology and overcoming its crisis status. The question of religious ideology in the legacy of a scientist is in organic relation with his own theory of ideology as such.
Development of the Jewish religious movement "Khabad" in Ukraine in the 20's of the twentieth century
Authors: Kozerod O. V.
Published: January 2019

The development of the Jewish religious movement "Khabad" and its organizations in the first quarter of the twentieth century - one of the important research problems, which is still practically not considered in the domestic Judaica. At the same time, this problem is relevant in connection with the fact that the religious movement "Khabad" during the twentieth century became the most widespread and influential area of Judaism in Ukraine and throughout the world.
The motive of God's loss in Ukrainian fairy tales
Authors: Yatchenko V.
Published: January 2019

If we approach the analysis of fairy tales from the point of view of revealing in them a metaphysical dimension of human intentions, then in their subjects one can identify several paradigms. The most important of these should include, in particular, the following: the combination of man with the deity (God); the loss of God's person as a result of her violation of some conditions for coexistence with God; the search for the lost man of God and the rejoining of him. These through-world ideological paradigms, embodied in specific themes (plots), may be adjoined in the same tale, and may exist separately, encompassing all of its plot. All the above applies to Ukrainian fairy tales.
In memory of colleague Anatoly Yerisheva
Authors: Of the Journal Editorial board
Published: January 2019

In memory of colleague Anatoly Yerisheva
Editorial Announces
Authors: Of the Journal Editorial board
Published: January 2019

Editorial Announces
Orthodoxy of pre-war Ukraine (1921-1939): the main tendencies of development
Authors: Sagan Oleksandr N.
Published: January 2019

The violent events of the revolutionary 1917 rocked the church life in Ukraine. Church movement began to become quite controversial in its content of national-political character. In the new political conditions, not only the clergy but also secular authorities, public organizations and private individuals took an active part in discussing the problems of church life, which politicized in some way Orthodoxy. The Civil War of 1918-1920 did all the efforts of church activists and clergy dependent on the state of affairs - the activity of many church and church organizations ceased or, on the contrary, restored under the rule of certain political forces. It was only from the beginning of 1921 that we could speak of more clearly defined lines of church development.
Factors affecting customer satisfaction and loyalty: A case study in Ben Tre
Authors: Si Nguyen Van , Bang Nguyen Viet
Published: January 2019

The paper defines and measures key factors affecting Homestay tourist loyalty in Ben Tre using qualitative and quantitative methods, in which the qualitative research is carried out through focus group discussions with 10 tourists and the other through direct interviews with 294 tourists in Ben Tre Province, Vietnam. The results show that: (i) tourist loyalty is affected by tourist satisfaction, Homestay service quality, cultural contact, tourist satisfaction, and local food; and (ii) tourist satisfaction is affected by Homestay service quality, cultural contact, and local food. However, the research has certain limitations, namely small sample size of 294 tourists and convenient sampling technique through direct interviews with respondents who are using Homestay service in Ben Tre.
Les principales questions juridiques posées par l’informatique en nuage
Authors: Ha Nguyen Nhu
Published: January 2019

Résumé—Les implications juridiques de l’utilisation de solutions de Cloud computing sont largement similaires à celles de tout contrat d’externalisation avec une tierce partie. Une différence majeure en utilisant un fournisseur de Cloud découle de la souplesse du mouvement des données entre les serveurs qui peuvent être situés dans diverses parties du monde. Il est donc difficile de déterminer quelle loi s’applique à un moment donné pour les données, notamment parce que les données peuvent également avoir été fragmentées en fonction notamment de la disponibilité ou de la capacité du service Cloud. Cet article recense les principales questions juridiques posées par l’informatique en nuage afin de déterminer l’ordre juridique qui assure une protection adéquate.
EVALUATION OF ELECTROMYOGRAPHIC NOISE STATISTICAL CHARACTERISTICS IN MULTICHANNEL ECG RECORDINGS
Authors: Grigoriev Evgene B. , Krasichkov Alexander S. , Nifontov Evgeny M.
Published: January 2019

Electromyographic noise is one of the most common noises in electrocardiogram. In case of several electrocardiogram leads, electromyographic noise affects each lead to different extent. It can be taken into account when developing algorithms for multilead electrocardiogram record processing. However, in the existing literature, there is no information about the relationship of electromyographic noise in various ECG leads and their joint probability distribution. The purpose of this paper is to study statistical characteristics of electromyographic noise in ECG signal, from which the electromyographic noise is extracted. The paper proposes a method for extracting electromyographic noise from electrocardiogram signal, based on a polynomial approximation of electrocardiogram signal fragments in sliding window with overlapping fragment subsequent weight averaging. Using this method, fragments of electromyographic noise are extracted from multichannel electrocardiogram records. Based on the obtained data, a joint probability distribution function of electromyographic noise in two adjacent leads is selected, and the correlation relationships between the electromyographic noise in various ECG leads are investigated. The results show that the joint probability distribution function of electromyographic noise in two adjacent leads in the first approximation can be described using bivariate normal distribution. In addition, between the samples of electromyographic noise from two adjacent leads quite strong correlation relationships can be observed.
BROADBAND MICROWAVE VIVALDI ANTENNA USING COPLANAR FEED LINE
Authors: Golovkov Alexander A. , Terenteva Polina V. , Zhuravlev Alexander G. , Shmyrin Michail S. , Stenyukov Nikolay S.
Published: January 2019

Nowadays Vivaldi antennas are used as directional emitters with matching and balancing device at the input. As a rule, these devices cause additional losses in case of broadband operation. Besides, the use of the device leads to radiator pattern distortions, especially when operating in a wide frequency range. Stringent operating requirements (wide operating temperature, high humidity, salt fog, vibration, etc.), make the choice of proper chip very complicated. The aim of the study is to develop a slot antenna with a 50-ohm port at the input, which would be easy to manufacture and operate, while maintaining high gain in a wide frequency range. As is known, the field structure in the coplanar line is close to the field structure in the slit field close to it. As is known, the field structure in the coplanar line is similar to the field structure in the slot line. Using mathematics for such fields, means of electrodynamic modeling and numerical calculation, a system is developed that consists of two Vivaldi antennas fed by one coplanar line. Thus, the emitter has a close to a circular pattern and low losses in the structure of feeding, matching and balancing, the functions of which are performed by the coplanar line. The results are given for the frequency range of 1-6 GHz. The device as a whole is a dielectric substrate with radiating structure made as double-sided metallization. Finline-based emitters are acceptable to use for operation in higher frequencies. Antenna has low manufacturing cost and it is easy to repeat. Currently the authors are continuing work on the study of the use of such elements as part of antenna arrays.
SIKAP KEMANDIRIAN SISWA DAN KEGIATAN EKSTRAKURIKULER DI SEKOLAH MAN 2 BOJONEGORO
Authors: Basith Abdul
Published: January 2019

This study aims to prove whether there are differences in independence attitudes possessed by active and non-active students in extracurricular activities. The results of this study are expected to provide useful information relating to the relationship between extracurricular activities and student independence. in addition, the results of this study are expected to be useful as a reference in developing extracurricular activities. The technique used for the normality test in this study was Lilliefors test and homogeneity testing between group A and group B was carried out before treatment was given.
PENINGKATAN KETERAMPILAN MENULIS PUISI DENGAN STRATEGI PIKIR PLUS MENGGUNAKAN MEDIA GAMBAR PERISTIWA
Authors: Tawakkal M Iqbal
Published: January 2019

The issues raised in this study is the low ability students' writing class VIII-A MTS Negeri Bojonegoro. It is caused by learning to write poetry that has not done well so class VIII-A MTS Negeri Bojonegoro have difficulty when asked to write a poem. Therefore, the necessary learning strategies and instructional media fun and appropriate. To overcome these problems Plus used Thought strategies and media images of events contained in the newspaper in teaching poetry writing class VIII-A MTS Negeri Bojonegoro. The research was conducted in two cycles. Each cycle consists of planning, action, observation and reflection. The results of this study indicate the existence of a process of learning, improvement, and change behavior in a positive direction
Distribution trend rabies in cats in Ukraine
Authors: Makovska I. F. , Nedosekov V. V. , Polupan I. M. , Latmanizova T. S.
Published: January 2019

In recent decades, there has been a rapid increase in the incidence of rabies in cat population due to lack of proper vaccination among domestic and stray animals. In such conditions, the virus is approaching the humans due to the increase in the number of cases of attacks of these animals on humans. Therefore, our aim was to carry out a retrospective analysis of the prevalence of rabies virus in Ukraine, to study the trends of rabies virus spread among domestic carnivores in recent decades, to establish the reasons for an increase in the proportion of cats in epizootic and epidemic processes in Ukraine. Having conducted a retrospective analysis from 1950 to 2017, we found that in 1950–1954 rabies in cats in the epizootic situation constituted a small percentage – 1.58%. In 1975–1979 there was an increase in the number of cases of the disease up to 17%, which occurred as a result of the epizootic outbreaks of rabies among the foxes that were most in contact with cats, especially stray, having common spatial and trophic bonds. Subsequently, trend of the development of rabies acquired a slight fluctuation, but the general trends of species distribution did not change significantly. However, in recent decades, the epizootic situation regarding this zoonosis among cats has become under constantly tension. An analysis of changes in the species structure from the total number of cats, who died of rabies in 1950 compared to 2017 showed an increase in the proportion from 1.58% to 30.5%. It is the highest percentage of cat rabies in Europe. After conducting an epidemiological analysis, we found that over the past decades, cats became the source of hydrophobia for every third patient. Our further research will be aimed at creating a database on the incidence of rabies in all species of animals in order to improve the program of rabies control among domestic carnivores and conduct a GIS-analysis on the territory of Ukraine.
Dynamics of blood immunological indicators in the period of the reproductive cycle under different technologies of keeping
Authors: Krempa N. U.
Published: January 2019

The obtained results of search on the influence of technology and conditions of sows holding of different physiological states on immunological parameters indicate that that the content of T-lymphocytes in the blank and sows of the first half of fertility in both farms was very high and exceeded the upper limit of physiological norm by 1–3% on average. However, with the onset of the second half of fertility and lactation in sows, a decrease in its level, fluctuating within the limits of the physiological norm (49.12%–51.37%), was noted. The content of T-helper cells in sows of all physiological groups of both farms was within the limits of the physiological norm. The difference between the indicators was the highest in sows of the second half of fertility – 8%, in favor of sows from the farm of the Staryi Sambir district. In other groups of sows the T-helper's content varied from 0.12% to 1.7%, with the overwhelming majority in favor of sows from the Zolochiv district. In fact, the same percentages were the indexes of the contents of T-suppressors of  blank and sows of the first half of the fertility of both farms. In the sows of the second half of fertility, the difference between the indicators of this population of lymphocytes was 3.37%, the predominantly higher rate was observed in sows from the farm of the Zolochiv district. In lactating sows, the difference in rates was significantly lower, only 0.88%, with a tendency for growth in animals from the Staryi Sambir district. An analysis of the level of humoral protection of the sow's blood of reproduction period showed, that in all physiological groups, except lactating, the content of B-lymphocytes was on average 0.38% – 0.95% higher was in sows from the farm of Zolochiv district. In lactating animals, the level of these lymphocytes was 3.75% higher in females from the economy of the Staryi Sambir district. The immunoregulatory index in almost all animal groups exceeded the upper limit of the physiological norm by 0.11%–0.48%. The exception was only sows of the second half of fertility from the farm of Zolochiv district and lactating sows from the economy of the Staryi Sambir district, where the index of IRI was at the level of the upper limit of the physiological norm, but did not exceed it. The phagocytic activity of neutrophils ranged from 38.68% to 63.05% and did not exceed the physiological norm. The index of phagocytic number in all groups of sows corresponded to physiological norms. Exceptions were sows from the economy of the Staryi Sambir district, the indicator corresponded to the value of 3.44, which is 0.56 less than the lower limit of physiological norm.
Investigation of the parameters of acute and acute toxicity of the “VetMicoDerm” liniment under the skin application
Authors: Martynyshyn V.
Published: January 2019

The toxicity parameters of “VetMikoDerm” for one-time and long-term skin treatment were investigated. The studied liniment as an off-white substance has a thio derivative of 1,2,4-triasole.  Spotted thistle oil is used as a solvent. The research of the determination of acute and low acute skin toxicity has been performed on young, healthy, healthy skin of the laboratory rats. The drug was applied in different doses to the stripped areas of the skin (area is not less than 10% of the total area of the skin). It was established that after a single application of the drug (24 hours) in a dose of less than 2000 mg/kg of body weight, the death of experimental animals or any signs of general intoxication of the body is not observed.  Local reaction (redness, itching, allergy, combing) is absent. According to GHS under the assessment in this dose studying the “VetMicoDerm” drug belongs to the 5th safety category (Grade 5, not classified). During a long-lasting application of the drug (28 days), the death of the rats was not adversed, the animals had a preserved appetite, responded adequately to external stimuli, reflex excitability was completely preserved.  Under hematological and biochemical studies of blood of the experimental animals, it was found that against the backdrop of insignificant increase in the number of white blood cells in their blood, the number of neutrophils increases and the percentage of lymphocytes decreases significantly. However, under the usage of the drug in the therapeutic dose (50 mg/kg body weight) the liver function has a tendency to increase. Increasing in dose (500 mg/kg) of the VetMikoDerm a 10-fold continued its application which  led to an increase in serum concentrations of urea and creatinine,increasing  the mass index can serve as a marker of renal decline functional condition of the body.
Morphological peculiarites and functional activity of adipose-derived mesenchimal stem cells during in vitro cultivation conditions
Authors: Kladnytska L. V. , Mazurkevych A. I. , Khomych V. T. , Mazurkevych T. A. , Stegney Z. G. , Maluk M. O. , Garmanchuk L. V. , Velychko S. V. , Danilov V. B. , Kharkevych Y. O. , Shelest D. V. , Velychko V. S. , Stupak I. A.
Published: January 2019

The studies were conducted on 2-3-months-old males of C57BL/6 mice weighing 20–24 g. Obtaining and cultivating of adipose-derived mesenchimal stem cells (AD MSCs) were carried out in a sterile laminar box with compliance of conditions of asepsis and antiseptics. AD MSCs of the 2, 4, 7 and 12 passages were analyzed. Morphometric analysis was performed using a light microscopy. Morphometric parameters such as cell and nucleus area or nuclear-cytoplasmic ratio (NCR) were calculated using the Axiovision light microscope (Carl Zeiss, Germany) and ImageJ 1.45 software. Trypan blue dye used for investigation of the viability of MSC. The morphological characteristics of mesenchymal stem cells from adipose tissue during the process of cultivation changes: at the first passages of cultivation, the cells are spindle-shaped with two, at least three, long long cytoplasmic processes, located bipolar. Near the nucleus the Golgi complex is clearly visible – a sign of active cells. At later passages cells have a small cytoplasmic processes and the bipolar arrangement of processes changes by stellar arrangement. Golgi complex is also clearly visualized. The indicator of the nuclear-cytoplasmic ratio in MSC from adipose tissue is significantly reduced at 7 passage to 0.2189 ± 0.0122 (P < 0.01), and at 12 passage to 0.1111 ± 0.0086 (P < 0.001) compared to the 2 passage. The coefficient of proliferation of MSC from adipose tissue is significantly reduced at 12th passage. The viability of mesenchymal stem cells from adipose tissue with an increasing of a number of passages significantly reduces and at the 12th passage of cultivation reaches 84,67 ± 1,36* (P < 0.05). The content of apoptotic cells that exhibited sensitivity to serum-free significantly increased at 7 and 12 passages and was respectively 21.33 ± 1.36 (P < 0.05) and 23.67 ± 0.97% (P < 0.05).
PCR-test system specific identification Parachlamydia acanthamoebae
Authors: Zezekalo V. K. , Peredera S. B. , Buslik T. V. , Pochernyaev K. F.
Published: January 2019

Chlamydia-like bacteria Parachlamydia acanthamoebae belongs to the phylum Chlamydiae, class Chlamydiia, order Chlamydiales, family Parahlamydiaceae, genus Parachlamydia. The following terms were introduced to designate Chlamydiales bacteria that are not members of the Chlamydia genus: Chlamydia-related bacteria – CRB, Chlamydia-like bacteria and Chlamydia-like organisms – CLOs. Parachlamydia acanthamoebae is associated with respiratory diseases in humans and ruminants, as well as diseases of the reproductive organs leading to abortions, or the birth of weak or non-viable offspring. Unfortunately, there are no such test systems in the arsenal of humane and veterinary medicine of Ukraine, which could identify and differentiate Сhlamydia-related organisms, Parachlamydia acanthamoebae in particular. In this regard, PCR test system has been developed for the identification and species differentiation of Parachlamydia acanthamoebae, the bacteria of the Parachlamydiaceae family, which is the causative agent of chlamydiosis in ruminants and humans. Conducted bioinformatics studies revealed species-specific regions of the Parachlamydia acanthamoebae genome, which were used to develop the nucleotide structure of oligonucleotide primers, which allow to amplify the DNA fragment of the 16S rRNA gene specific for the bacterium Parachlamydia acanthamoebae, the size of 88 base pairs. Verification of the analytical specificity of the PCR test system was confirmed by amplifying 9 control DNA of members of the order Chlamydiales: Waddlia chrondophila, Clavochlamydia salmonicola, Piscichlamydia salmonis, Chlamydia avium, Chlamydia pecorum, Chlamydia abortus, Chlamydia psittaci, Chlamydia suis, Chlamydia caviae. The demand for such test systems is due not only to their use in scientific research to isolate and study individual strains, to conduct epizootic monitoring, but also for the purpose of effective treatment, since distinct species have diverse sensitivity or even insensitivity to different types of antibiotics and vary in the source of infection and mode of transmission.
Toxicological characteristics of the preparation FORTICEPTTM Hoof Oinment
Authors: Ishchenko V. D. , Shevchenko A. M. , Slobodyuk N. M. , Vasiv R. O. , Yarova H. V. , Ishchenko Y. A.
Published: January 2019

Antibiotic resistance of the main infectious disease pathogens is one of the biggest problems of present time, which causes the need for searching for new antimicrobial medicinal substances and developing effective medicinal agents. One of the innovative medicinal preparations with the antimicrobial action, which is recommended for application for animals with hoof diseases, is ForticeptTM Hoof Oinment. Integration in the practice new medicinal preparations needs their strict toxicological control, which involves the exploring of acute and chronic toxicity and remote effects of possible side effect. The purpose of work was the determination of the acute toxicity parameters of the ForticeptTM Hoof Oinmentduring the oral administration to white laboratory mice and evaluation of the skin resorptive action of the preparation after it was administrated on rats’ skin. For determination of the acute toxicity there were used male laboratory mice with the average weight of the body 20 g – two groups with 10 animals in each. For the first group (the control one) with the help of the probe there was injected the distilled water (0.1 ml) into stomach. For the second group there was injected ForticeptTM Hoof Oinment (0.1 g), where the dose of the preparation is equal 500 mg/kg. For evaluation of the skin resorptive action of the preparation there were used 6 white rats with the average weight of the body 175 g. On the pre-prepared patch of skin there was administrated the preparation in the number that is equal 2857 mg/kg of body weight. For control there was leaved a free from preparation patch of bare skin. Exposition lasted for 4 hours. The indicators were explored in dynamics after 6, 24, 48 hours from the exposition started. After the research results there was established that ForticeptTM Hoof Oinment doesn’t cause death after its intragastric administration to the white laboratory mice in the number that is equal 5000 mg/kg of the body weight, that’s why depending on the degree of toxicity it belongs to the V toxicity class (Practically nontoxic). After one-time application of the preparation to the white rats in the number which is equal 2857 mg/kg of the body weight there wasn’t observes no death or pronounced changes in the behavior reactions, motor activity, state of the nervous system, amount of the consumed food and water. Therefore ForticeptTM Hoof Oinmentaccording to the results of the determination of the acute toxicity after its administration on the skin to the white rats depending on the degree of toxicity it belongs to the V toxicity class (Practically nontoxic). ForticeptTM Hoof Oinment doesn’t detect skin resorptive action, that points on the absence of toxic effects of the preparation due to its application on the skin.
Distribution and structure of the pathology of the prostate gland in dogs
Authors: Bondar S. V.
Published: January 2019

The article presents the results of the study of the structure of the pathology of the prostate gland in dogs in the age aspect. The study of the spread of the pathology of the prostate gland in dogs was conducted on the basis of the center of veterinary medicine “Health”, Sumy and clinics of the Department of Obstetrics and Surgery, Sumy National Agrarian University during 2014–2018. At the same time, 985 dogs of all ages and breeds were examined for this period, from which 101 animals with pathology of the prostate were isolated. Pathology of the prostate gland in dogs is 10.3% of the total number of examined animals. Among prostate diseases the most common are benign hyperplasia – 47.5%, prostatitis – 36.6% and neoplasms – 10.1%, from the total number of animals with diseases of the prostate gland. For dogs most widespread among pathology of prostate gland are of high quality гіперплазії, простатити and неоплазії that fold 47.5%, 36.6% and 10.1%, from the incurrence of animals with illnesses of prostate. On the stake of chronic inflammation among the general amount of animals with простатитом, there is 2.6%, and on a sharp and festering form – 0.7% and 0.4%, accordingly. For dogs it follows reasons and contributory infringement factors of origin of простатитів to count cystitises, urethritiss, pyelonephritises, баланопостити, traumas of penis, and also obesities of animals, reductions of motive activity, that arise up as secondary distribution of inflammatory process on a prostate gland. Researches of age-old dynamics of простатитів testify for dogs, that frequency of this pathology grows with age. In the age-old aspect, the rate of detection of prostatitis reaches a maximum at the age of 7–8 years, and somewhat less in 5–6 and 9–12 years, accounting for 54.1%, 18.9% and 13.5% of the total number of animals with inflammatory processes prostate gland, respectively. At the age of 7–8 and 9–12 years, the dominant form of prostatitis is chronic, accounting for 80% and 100% of the total number of diagnosed cases of prostate inflammation for each group, while at the age of 5–6 and 3–4 years the frequency of detection of acute and purulent forms of prostatitis is 40% and 20% and 50% and 25%, respectively.
The effect of silicon compounds on hematological indicators and content of lipids in blood of rabbits
Authors: Ivanitskaya A. I. , Lesyk Ya. V.
Published: January 2019

The aim of the study was to find out the effect of casting of citrate nanosіlicon absorption and metasilicate sodium on the hematological parameters and lipid content and their fractional composition in blood plasma preparatory period 10 days prior to insemination and 20 days of lactation. The research was carried out on 60 rabbits of the Hyla hybrid, divided into three groups (control and two experimental), with 20 animals in each. The control animals were fed without limitation full-grain granulated feed with free access to water. Animals of the first experimental group (E-I) fed the diet of the control group and during the course of the day poured out the silicon citrate obtained using the nanotechnology method, 50 mkg Si/kg body weight with water. Samples of the second experimental group (E-II) feed the diet of the control group and set the sodium metasilicate (Na2SiO3H2O) 2.5 mg Si/kg body weight with water. The trial lasted 95 days, including the preparatory period of 10 days, the trial – 85 days. In the preparatory period of 10 days from the beginning of the study and in a trial of 20 days of lactation (65 days of supplements) in the rabbits, samples of blood from the marginal ear vein were taken. Hematologic studies were performed using the automatic hematologic analyzer “Orphee Mythic 18”, in the blood plasma, the content of total lipids and their fractional composition were determined. It was established that the number of erythrocytes and hemoglobin concentration in the blood of the rabbits of experimental group, which were given silicon citrate, were respectively higher by 15.2% (P < 0.05) and 12.0% (P < 0.01) by 20 days lactation versus control. This may indicate a more pronounced effect of the organic compound of silicon on the hematopoietic function of the body of the rabbits. According to white blood, the differences from control were found during the presentation of supplements with higher (P < 0.05) changes in 20 days of lactation in animal blood and experimental group. It was noted that the content of triacylglycerols in plasma of blood of groups I and II was lower by 31.2 and 32.8%, respectively (P < 0.05) compared to control. In blood plasma of animals in experimental groups an increase in the fractions of phosphatidylcholine, sphingomyelin and lysolecetin was observed compared to control. Such a redistribution was due to the reduction of the fractions of phosphatidic acid, phosphatidyl ethanolamine and phosphatidylinositol, and apparently, is associated with changes in the activity of the enzymes concerned. Hematological studies and determination of the fractional composition of lipids and phospholipids of blood plasma of the rabbits show positive changes that contribute to the metabolic accumulation of energy and plastic components of their organism.
Glutathione peroxidase of blood of dogs and cats with mammary tumors
Authors: Fedets O. M. , Kurlyak I. M. , Zayats O. I.
Published: January 2019

For timely diagnostics and successful treatment of mammary tumors in human and animals a necessary search of compounds that can be the biomarkers of this disease is needed. The aim of our work was to measure the activity of glutathione peroxidase (GPx) in blood plasma and erythrocytes of dogs and cats with mammary tumors and healthy animals for establishment of intercommunication between enzyme's activity and tumors. For researches took away blood at three groups of animals: 1) four healthy females of dogs (Canis familiaris) – the German Shepherd dogs by age 3, 6, 7 and 7; 2) four females of dogs with mammary tumors – the Russian Spaniel dog by age 8, Boxer dog by age 9 and the German Shepherd crossbred dogs by age 11 and 12; 3) four females of cats (Felis catus) with mammary tumors – crossbred cats by age 6, 8 and 10 and the Persian crossbred cat by age 13. Activity of GPx was determined by decrease of reduced glutathione in a presence of hydrogen peroxide for time unit with a count on the gramme of protein in blood plasma, or haemoglobin in erythrocytes. In the sick dogs’ erythrocytes the activity of GPx presents 30.45 ± 3.08 mmol GSH/min×g haemoglobin and it is more than for the healthy animals of 27.84 ± 5.24 mmol GSH/min×g haemoglobin, these differences aren't statistically reliable however. This index is the highest for the sick German Shepherd crossbred dog aged 11 and presents 38.5 mmol GSH/min×g haemoglobin. In sick dogs’ activity of GPx in blood plasma is 7.45 ± 1.60 mmol GSH/min×g protein and it is statistically reliable less than the healthy animals of 12.77 ± 1.18 mmol GSH/min×g protein. This index is the lowest for the the 12 years old sick German Shepherd crossbred dog and it is 3.41 mmol GSH/min×g protein. In sick cats activity of GPx in erythrocytes is 41.57 ± 4.10 mmol GSH/min×g haemoglobin, and the greatest it is in the sick crossbred cat age 10 – 52.52 mmol GSH/min×g haemoglobin. The activity of the enzyme in blood plasma of sick cats is 11.58 ± 1.99 mmol GSH/min×g protein and this index is similar to the healthy dogs. Activity of GPx of the erythrocytes of dogs and blood plasma of cats with mammary tumors did not differ from healthy dogs. The activity of GPx of sick dogs only in blood plasma is less than in healthy ones. It can be the consequence of this “exhaustion” of the enzyme and its involving in the process of neutralizing of active forms of reactive oxygen species in those tissues of organism where oxidizing stress develops. Next to the study of expression on the future it is necessary to pay attention to the study of polymorphism of GPx.
Retos epistemológicos de la interculturalidad en contexto indígena
Authors: Quilaqueo Daniel , Sartorello Stefano
Published: January 2019

En este ensayo examinamos la concepción de interculturalidad a partir de las asimetrías epistémicas entre los conocimientos indígenas y los conocimientos de la escuela. El análisis considera una perspectiva crítica del concepto de interculturalidad y un enfoque epistémico-pedagógico indígena de generación de conocimientos educativos interculturales, basado en lo social y cultural. Argumentamos que el sistema escolar niega las racionalidades epistémicas que sustentan el sistema de conocimiento indígena y dificulta la articulación intercultural cuando se enfatizan solo los aspectos culturales propios. Concluimos que el desafío para una interculturalidad crítica, en contexto indígena, es epistemológico estructural.
El amor destructor de la interdicción: una propuesta de análisis de la autotraducción en la poesía mapuche desde el giro afectivo
Authors: Stocco Melisa
Published: January 2019

Este trabajo intenta esbozar ciertas reflexiones en torno al papel de los afectos en la práctica de la autotraducción en la poesía mapuche. Vemos en el “giro afectivo” una posibilidad de comprender la producción literaria bilingüe de autores mapuches como un proyecto ético de reapropiación lingüística y de transgresión de límites culturales originado en afectos de “pulsión genealógica” que ponen en cuestión la autoridad de la lengua del colonizador, a la vez que resultan en la generación de los llamados “afectos activos”, propios de un aumento del grado de potencia expresiva y de agenciamiento de los sujetos. Para ello trazaremos una cartografía de conceptos de distintos pensadores que han reflexionado acerca de los afectos y la lengua, desde Jacques Derrida a Gloria Anzaldúa, pasando por el ineludible Gilles Deleuze en su estudio de los afectos en la Ética de Baruch Spinoza. Asimismo, pondremos estos conceptos en diálogo con las propias reflexiones de varios autores mapuches: Liliana Ancalao, Adriana Paredes Pinda, María Teresa Panchillo, Leonel Lienlaf y Elicura Chihuailaf.
Del Essex a Melville. Reescrituras del mito de la ballena blanca en la novela gráfica Mocha Dick
Authors: García Reyes David
Published: January 2019

La imagen de Moby Dick de Herman Melville, novela fundacional de la narrativa estadounidense, tiene su origen en las costas del sur chileno. El repertorio precedente de la obra literaria propuesto por Wolfgang Iser presenta un proceso en el que se producen diferentes versiones del mito. La novela gráfica Mocha Dick, con textos de Francisco Ortega y dibujos de Gonzalo Martínez, es una de esas versiones. La historieta chilena plantea un diálogo con los textos precedentes y propone una revisión de Melville y de los orígenes de la legendaria ballena blanca.
Geología de un planeta sombrío.
Authors: Arancibia Venegas Felipe
Published: January 2019

Geología de un planeta desierto (2013) es una novela que se desarrolla en Antofagasta; una ciudad del norte de Chile cuyas tierras acogieron a Patricio Jara –el autor de este libro– y su familia durante gran parte de su vida. En Geología, Jara cuenta la relación de un hijo (Rodrigo) con su padre –quien aparece en la novela como un fantasma; el progenitor de Rodrigo–, aquel hombre trabajador, que por razones externas a el, tuvo que jubilar  prematuramente a los cincuenta años. Aquel hombre no pudo reponerse a aquel golpe, por lo que se vuelve un hombre alcohólico como forma de olvidar su desdicha.
¿Ut pictura poesis? relaciones entre pintura y literatura en la teoría estética de Diderot
Authors: Olszevicki Nicolás
Published: January 2019

El abordaje especulativo de los problemas artísticos realizado por el philosophe Denis Diderot (1713-1784) a lo largo de su carrera, desde sus tempranos Pensamientos filosóficos (1746) hasta El sobrino de Rameau –obra póstuma que fascinó a Goethe– ha sido objeto de estudio de una bibliografía vastísima, algunas de cuyas tesis no dejan de sorprender al estudioso: no tanto por el carácter original o provocativo que presentan sino por el mucho más simple hecho de que, a menudo, suelen contradecirse entre sí.Esto resulta evidente cuando se revisa el modo en que nuestro autor, en consonancia con las preocupaciones epocales, concibe y elabora la relación entre las artes particulares, específicamente, entre la pintura y la poesía. En efecto –y aquí está lo que nos ha llamado la atención en nuestra investigación– críticos e historiadores del arte y de la literatura que han abordado desde una perspectiva histórica y teórica las implicancias del tópico ut pictura poesis en la tradición estética occidental toman frente a Diderot.