bluuebunny/crossref_metadata_2025 huggingface dataset:
CENPW as a biological indicator: predicting prognosis and guiding treatment in a patient with Kidney Renal Clear Cell Carcinoma
Authors: Deng Shijie , Han Tingting , Huang Qimei , Lu Jing , Yu Zhaoxia
Published: March 2023

Purpose: Employing data obtained from The Cancer Genome Atlas (TCGA)and GEO database to investigate whether the centromere protein W(CENPW) gene can be used as a biological marker for prognosis and guiding therapy for kidney renal clear cell carcinoma (KIRC).
Methods: KIRC patient’s transcriptome profiling data and clinical data were downloaded from the TCGA and GEO database. Thereafter, TIMER2.0 was used to analyze the expression of CENPW in normal and tumor tissues. Single-gene differential analysis and survival analysis were used to demonstrate the relationship between CENPW expression and prognosis. Clinical correlation analysis and univariate and multivariate analysis were utilized to identify the expression relationship of target genes in clinical features. Receiver operating characteristic curves ROC was harnessed to assess the reliability and sensitivity of CENPW as a predictor of prognosis. Further, Nomo plots and prognostic nomograms were established to predict probable 1-, 3-, and 5-year overall KIRC patient survival. Moreover, gene co-expression analysis was used to analyze the relationship between target genes and co-expressed genes. In addition, functional enrichment analysis was employed to identify the biological functions of CENPW. GSEA was performed to explore underlying biological processes and cellular pathways. Finally, immune cell infiltration analysis, clustered KIRC patients were performed according to the expression of CD8(+)T cells and performed immunotherapy analysis and drug sensitivity tests among the two clusters. At the same time, we also performed HE staining and CD8 immunochemical staining in tumor tissues and normal tissues. The results of IHC staining were quantified for differential and survival analysis.
Results: We constructed and validated the CENPW prognostic signature of KIRC patients in the TCGA and GEOdatabase. It was thereafter confirmed that patients with high CENPW expression had a poor prognosis, while the ROC curve (AUC at 5 years: 0.658) indicated that CENPW had reliable predictive power. Subsequently,a prognostic nomogram was built and achieved strong predictive accuracy. Some chemical drugs such as 17-AAG, CCT018159 and CI-1040 were more sensitive in cluster 1 than in cluster 2. In addition，there was significant difference between cluster 1 and cluster 2 in PD-1 and CTLA4 immunotherapy.
Conclusion: CENPW may be employed as a biological indicator for prognosis and guiding treatment in KIRC patients.
Primary bladder neck obstruction in men – what´s new in the pathophysiology of this underestimated problem?
Authors: Cash Hannes , Wendler Johann , Minore Antonio , Goumas Ioannis Kartlas , Cindolo Luca
Published: March 2023

Primary bladder neck obstruction (PBNO) is a dysfunction of the bladder neck (BN) in which the collum vesicae is narrow or fails to open adequately during voiding, resulting in a bladder outlet obstruction. PBNO causes storage or voiding LUTS often years before a correct diagnosis of PBNO is made. These patients have often been seen by many physicians and misdiagnosed as having psychogenic voiding dysfunction because of a normal prostate on rectal examination, a negligible residual urine volume, and a normal endoscopic bladder and prostate appearance. The cause of PBNO has not yet been clarified and has so far been a clinical differential diagnosis after the exclusion of the usual differential diagnoses of LUTS and bladder emptying disorders. Several publications let assume that PBNO could be induced by inflammatory processes, possibly by the same inflammatory patterns that have been previously described for BPH development, leading to an initially reversiblel and later irreversible remodeling of the connective tissue of the BN. The clinical value of these observations consists of a correct and precise diagnostic framework especially in young men referring pelvic pain and LUTS despite their small prostate volumes. The proper diagnosis could provide a tempestive calculated therapy proposal that can stop illness progression or in same cases reverse inflammation and collagenic deposition, limiting the risk of future obstruction and symtomatic progression.
The Role of T1 and T2 Mapping on Cardiovascular Magnetic Resonance Imaging in Sudden Cardiac Arrest Survivors
Authors: Gil Katarzyna Elżbieta , Truong Vien T , Zareba Karolina M , Varghese Juliet , Simonetti Orlando P , Rajpal Saurabh
Published: March 2023

Purpose
Etiology of sudden cardiac arrest (SCA) is identified in less than 30% of survivors without coronary artery disease. We sought to assess the diagnostic role of myocardial parametric mapping using cardiovascular magnetic resonance (CMR) in identifying SCA etiology.
Methods
Consecutive SCA survivors undergoing CMR with myocardial parametric mapping were included in the study. The determination if CMR was decisive or contributory in identifying SCA etiology was made if the diagnosis was unclear prior to CMR, and the discharge diagnosis was consistent with the CMR result. Parametric mapping was considered essential for the CMR diagnosis if the SCA etiology could have not been determined without its utilization, and contributory if the diagnosis could have been potentially based on the combination of cine and LGE imaging, without optimal assessment of the severity and prognosis of the disease (offered by parametric mapping).
Results
Of the 35 patients (mean age 46.9 ± 14.1 years; 57% males) included, diagnosis was based on CMR in 23 (66%) patients. Of those, parametric mapping was essential for the diagnosis of myocarditis and tako-tsubo cardiomyopathy (11/48%) and contributed to the diagnosis in 10 (43%) additional cases.
Conclusion
Inclusion of quantitative T1 and T2 parametric mapping in the SCA CMR protocol has the potential to increase diagnostic yield of CMR and further specify SCA etiology, especially myocarditis. CMR performed early after SCA may aid in the decision-making regarding ICD implantation.
The Comparison of the mental health of nurses and non-medical staff during the coronavirus outbreak
Authors: Ardestani Seyed Abolfazl Fatemi , Mohammadi Amir Hossein , Salehi Ali , Rahimi Habibollah , Sepehrmanesh Zahra
Published: March 2023

Background: Given the importance of improving the hospital's staff’s mental health and its key role in the quality of the services provided and also paying attention to the fact that the mental health of nurses and the non-medical staff in Iran hasn't been compared before during the covid-19 pandemic; this study was conducted with the aim of comparing the mental health of these two groups during the mentioned time.
Methods: This cross-sectional study was conducted on 67 non-medical staff and 61 nurses in 2020 in Kashan, Iran. Samples were obtained using the convenience sampling method and in order to collect the required data, the GHQ-28 (general health questionnaire) and the demographic characteristic questionnaire were used. At the end the data were analyzed using SPSS software.
Results: The mean and standard deviation of participants' age was 36.29±8.58 and their work experience was 11.76±8.34. The sex ratio was, 97 (75.8%) female and 31 (24.2%) male. Sixty six (51.6%) participants had a score higher than the questionnaire cut-off. GHQ-based mental health score in nurses was significantly higher than the non-medical staff (p= 0.007). Also, the prevalence of possible disorders based on GHQ cut-off point in nurses was significantly higher (p= 0.002).
Conclusion: Our study showed that the non-medical staff had better mental health during the covid-19 outbreak compared to nurses. Thus, taking nurses' mental health into consideration is of great importance.
Efficient Implementation of Double Random Phase Encoding and Empirical Mode Decomposition for Cancelable Biometrics
Authors: Salama Gerges M. , El-Shafai Walid , El-Gazar Safaa , Omar Basma , Hassan A. A , El-Samie Fathi Abd , Hussein Aziza
Published: March 2023

The authors have requested that this preprint be removed from Research Square.
Fault Diagnosis Evaluation Method and Index System in Digitalized Distribution Substation Areas
Authors: CHEN Jie , SHENG Wanxing , GUAN Shilei , ZHOU Feiyan , ZHAO Bo , SHI Changkai
Published: March 2023

Digitalized distribution substation areas constructed with intelligent transformer terminals can realize various advanced application scenarios using IoT technology, which provides a new perspective for fault diagnosis problem solving in power distribution systems. This paper briefly introduces the principle of fault diagnosis based on a digitalized substation area. Then, we propose a fault diagnosis effectiveness evaluation index system containing first priority qualification indices, second priority performance indices, and an index weight calculation method based on the hierarchical analysis method and improved entropy weight method. Through a fuzzy comprehensive evaluation method, a comprehensive evaluation of the fault diagnosis effectiveness is carried out. At the end of this article, the effectiveness of the proposed evaluation method and index system is verified through example analysis.
Characterization of a novel VenusX orthogonal dual-layer multileaf collimator
Authors: Wang Qingxin , Wang Zhongqiu , Yang Chengwen , Zhang Daguang , Wang Jun , Wang Ping , Li Qifeng , Wang Wei
Published: March 2023

Background
We investigated and characterized the performance of a novel orthogonal dual-layer multileaf collimator (αMLC) mounted on the LinaTech VenusX medical linear accelerator.
Methods
We evaluated leaf positioning accuracy and reproducibility using electronic portal imaging device (EPID) images of the picket fence test. The average, interleaf, and leaf-end transmissions of the upper, lower, and both αMLC layers were measured using an ionization chamber or EPID. The square and rhombus fields were used to evaluate the leaf penumbra of αMLC. To investigate the advantages of an orthogonal dual-layer MLC in field shaping, a right triangular pattern field, and a circular pattern field were formed using both layers and a single layer of the αMLC. These two evaluation pattern fields imaged were acquired by EPID and compared.
Results
The deviations in the positioning accuracy of the upper and lower MLC were 0.76 mm and 0.62 mm, respectively. Reproducibility was 0.29 mm and 0.26 mm correspondingly. The measured average transmissions were 1.86%, 1.82% and 0.03% for upper-, lower- and dual-layer MLC, respectively. The maximum interleaf transmission of the lower-layer MLC was 2.22% and 0.21% for the dual-layer. The maximum leaf-end transmissions were 23.90% and 0.44% correspondingly. Penumbra of the square field is 6.2 mm in X direction and 8.0 mm in Y direction. Average penumbras of the rhombus fields with side lengths of 5 cm and 10 cm were 3.6 mm and 4.9 mm, respectively. For the right triangular and circular fields, the fields shaped by the dual-layer of the αMLC were much closer to the planned field than the single-layer MLC. The dose undulation amplitude of the 50% isodose lines and the leaf stepping angle change of both layers was smaller than the single-layer MLC.
Conclusions
The αMLC benefits from its orthogonal dual-layer design. Leaf transmission, dose undulations at the field edge, and MLC field dependence of the leaf stepping angle of the dual-layer αMLC were remarkably reduced. αMLC can potentially improve the quality of IMRT and VMAT plans.
Ultrasound of Non-Hodgkin Lymphoma Involving Soft Tissue of the Arm: a case report.
Authors: Ciampi Saverio Antonio , Petrelli Cosimo
Published: March 2023

An 80-year-old woman presented to the hospital with a 11-month history of swelling that progressively involved the whole left upper limb. Her clinical history was rilevant for arterial hypertension, obesity and rheumatoid arthritis. Ultrasonography revealed hypoechoic nodules in soft tissue of the left arm,brachial vein thrombosisandmalignant left axillary lymphadenopathy. The patient started antithrombotic therapy and underwent axillary lymph nodes excisional biopsy: a diagnosis of diffuse large B-cell lymphoma was made and she was referred to hematology clinic for chemotherapy. At a 3-month follow-up visit, the patient showed decrease of the swelling of her upper limb; the ultrasonographic control demonstrated reduction in size and number of soft tissue nodules and resolution of vein thrombosis.
Trade-in Goods and Trade in Services: The Picture After 2008
Authors: Noor Thuhid , Tabassum Bushra
Published: March 2023

The goods and services sectors are contributing to a larger scale of GDP in OECD countries following the great recession of 2008. Using a structural gravity model and the constructed home bias index in a panel structure from 2007 to 2017 for OECD countries, this paper shows that trade in goods facilitates trade in services for the USA and the UK. Also, the USA has the highest magnitudes with a surplus in the services sector among all OECD countries. At the country level, a country with higher trade in goods will have more top trade in services. This study finds that the pattern of trade for OECD countries is ambiguous. Surprisingly, the services sector is growing faster than the goods sector in Canada after 2015 as the Canadian government opened the door to skilled immigrants.
JEL Codes: F13, F14, F15, and F62.
Does occupational radiation exposure affect retinal nerve fiber thickness?
Authors: Koc Hakan , Ozen Serkan
Published: March 2023

Purpose
To evaluate the thickness of peripapillary nerve fibers in radiation-exposed healthcare workers.
Method
The study included 60 radiation-exposed healthcare workers and 60 healthy control groups. SD-OCT was used to measure mean peripapillary RNFL thickness along with peripapillary RNFL thickness in the upper, lower, nasal, and temporal quadrants.
Results
The mean age of the subjects participating in the study was 37 ± 6.3 in the radiation-exposed group and 38 ± 4.9 in the control group. The mean duration of exposure to radiation in healthcare workers was 11 ± 5 years. While the mean total rim thickness was 94.25 ± 8.2 in the radiation exposed group, it was 102.8 ± 7.4 in the control group. (p < 0.001) The mean superior rim thickness was 123.93 ± 15.13 in the radiation exposed group, was measured as 129.75 ± 14.64 in the control group. (p = 0.34) While the mean inferior rim thickness was 110.88 ± 13.43 in the group exposed to radiation, it was 130.08 ± 13.44 in the control group. (p < 0.001) The mean nasal rim thickness was 70.25 ± 9.50 in the group exposed to radiation, while it was 75.38 ± 13.77 in the control group. (p = 0.46) While the mean temporal rim thickness was 71.77 ± 8.73 in the group exposed to radiation, it was measured as 75.78 ± 13.15 in the control group. (p = 0.52). Significant thinning of nerve fiber thickness was found statistically significant in all and especially the inferior quadrants of the healthcare workers exposed to radiation compared to the control group.
Conclusion
After at least 5 years of radiation exposure, the thickness of the peripapillary retinal nerve fibers may decrease in healthcare workers.
Weak interaction based interpretation of crystal packing characteristics of aromatic rings accumulating molecules: Hirshfeld surface analyses reinforced X-ray crystal study on 1,8-dibenzoyl-7-ethoxynaphthalen-2- ol and its 2-ethoxylated homologue
Authors: Iida Kikuko , Doi Taiki , Isogai-Koda Atsumi , Noguchi Keiichi , Yonezawa Noriyuki , Okamoto Akiko
Published: March 2023

The molecular vicinity characteristics in the crystal of two
dibenzoylnaphthalene derivatives having intimately similar
molecular formula with solely one substituent difference, 2-hydroxy
group or 2-ethoxy one, were comparatively investigated in relation
to the types of weak interactions with the aid of X-ray
crystal structural study reinforced by Hirshfeld surface analyses
and two-dimensional plotting of the normalised interatomic distance
crossing the molecular surface. The general X-ray crystal
structural analysis has selected the effective non-covalent bonding
intra/intermolecular interactions as the governing interactions for
the molecular packing on the basis of short interatomic distances.
The minute spatial structure around respective interaction
demonstrates the characteristics of the non-covalent bonding
interatomic interactions. The general X-ray crystal structural
analysis also reveals the relationship between the whole
crystalline symmetricity and the fashion of the interactions. The
Hirshfeld surface analysis displays the location of the short
contacts on the molecular surface. The two-dimensional plotting
reveals the contribution of the interacting atomic pairs covering
the molecular surfaces as the geometrical distribution of the
effective intermolecular non-covalent bonding interactions. The
difference in the revealed packing features and whole proximity for
two compounds are rationally interpreted according to the strength
categorization of the non-covalent bonding interactions especially
in relation with the proportional/disproportional distribution of
the molecular contact index. The comparison illustrates the
superior intermolecular interaction concentrates the short
interatomic distances and strain at the specified region of the
molecular aggregate resulting in arise of satisfactory flexibility
of the extroverted sides to realise highly symmetrical
interactions.
Cell clusters in intervertebral disc degeneration:An attempted repair mechanism aborted via apoptosis
Authors: Lama Polly
Published: March 2023

Cell clusters are a histological hallmark feature of intervertebral disc degeneration. Clusters arise from cell proliferation, are associated with replicative senescence, and remain metabolically active. Their precise role in stages of disc degeneration remain obscure. The aim of this study was therefore to investigate small, medium, and large size cell-clusters during degeneration. For this purpose, human disc samples were collected from 55 subjects, aged 37-72 years, 21 patients had disc herniation, 10 had degenerated non-herniated discs, and 9 had degenerative scoliosis of spinal curvature < 45°. 15 non-degenerated control discs were from cadavers. To corelate, abnormal loading on clustering process, 18-month-old, 10 male and 10 female sprague dawley rat spines were compressed with a custom-built loading device to induce tissue damage and stimulate attempted repair response. Clusters and matrix changes were investigated with histology, immunohistochemistry, and SDS-PAGE. Data obtained were analyzed with spearman rank correlation and ANOVA. Results revealed, small and medium-sized clusters were positive for cell proliferation markers Ki-67 and proliferating cell nuclear antigen (PCNA) in control, slightly degenerated human, and rat discs loaded for <= 7 days. Large cell clusters were typically more abundant in severely degenerated and herniated human discs, and in rat discs loaded for <=30 days. Large clusters associated with matrix fissures, proteoglycan loss, MMP-1, and Caspase-3. Spatial association findings were reconfirmed with SDS-PAGE that showed the presence of target markers within the dense matrix by its molecular weight. Controls, slightly degenerated discs showed smaller clusters, less proteoglycan loss, MMP-1, and caspase 3. In conclusion, this study shows cell clusters in the early stages of degeneration could be indicative of repair, however sustained loading and inflammatory catabolism alters cellular metabolism facilitating formation of large clusters, thus attempted repair process fails and is aborted at least in part via apoptosis.
Efficiency evaluation of public hospitals in Kuwait: an application of data envelopment analysis
Authors: Alsabah Abdullah M. , Alatawi Ahmed D. , Koornneef Erik
Published: March 2023

Background: Kuwait overall health expenditure, in 2019, was 5.5% from the gross-domestic product and the state is the biggest healthcare provider in secondary and tertiary hospitals. Hospital efficiency and productivity are, therefore, an important issue to analyse, specifically in terms of number of visits to outpatient clinics, the number of surgical procedures performed, bed turnover and bed occupancy. Data envelopment analysis has been used to provide insights in the understanding of this growth in other countries.
Methods: Data envelopment analysis (DEA) was used to estimate technical and scale efficiency scores for seventeen public hospitals in Kuwait from 2015 to 2019 using a two-stage DEA. Technical efficiency scores were regressed against institutional characteristics using Tobit regression to investigate the determinants of efficiency differences amongst hospitals.
Results: The mean technical efficiency score for all hospitals was 75%, and it improved by 1% since 2015. The mean pure technical efficiency score was 85% in 2015 and improved to 86% in 2019. The mean scale efficiency score was 89% in 2015 and decreased to 88% in 2019. Only five hospitals were constantly technically and scale efficient. Tobit regression showed that hospital efficiency was significantly associated with the hospital level (secondary or tertiary), number of beds, bed occupancy rate and the average length of stay.
Conclusions: Most public hospitals in Kuwait were not technically and scale efficient, but improvements were observed in the overall scores and pure technical efficiencies of these hospitals throughout the study. The identification of the factors influencing efficiency is crucial for hospital managers and policymakers to take evidence-based decisions to improve the technical efficiency of the main health-producing units in the country.
Studying the Awareness of Syrian Private University Students About H. Pylori
Authors: Shekri Ahmad , dayoub Kumait , Ali Ayman
Published: March 2023

Introduction: Helicobacter pylori (H. pylori) is a spiral-shaped, Gram-negative bacterium that affects up to 50% of the population worldwide. In our study, we aim to determine the level of awareness of the students of the Syrian Private University about this germ. Methods: A cross-sectional study in which a knowledge questionnaire was relied upon that included asking about a group of personal information and measuring knowledge of H. pylori, and this knowledge was tested with appropriate statistical tests. Results: Our study shows that there is average knowledge among university students about H. pylori, and their information is closely related to previous knowledge of the bacterium, the academic year, and sources of knowledge.
Influence and viability of IgG with altering ionic strength for multianalysis on microprinted biosensor.
Authors: Sruj D M
Published: March 2023

This paper elaborates on the biochemical nature of an IgG in a low or deionized environment. It has comparisons with two extremes of ionic strength, one is the Dulbecco’s Phosphate Buffer Saline (DPBS) and the other is the Deionised water (DIW). The experimentation performed is a prerequisite for orientation and immobilization of the IgG by exploiting its dipolar nature. However, no electric field is used in this setup, but the functionality of Ab-Ag interaction in respective media is emphasized. An additional epoxy layer has been used as support matrix to hold the capture IgG molecules, and also to understand its survival in a non-ionic atmosphere. A non-competent site directed assay is chosen, a mathematical estimate of the fluorescent endpoint can be analyzed and minimize the sample preparation time. The device built, is a step towards miniaturized immunosensor and a microarray is designed with improvisations for better signal and noise estimations. Therefore, the substrate developed is portable and aids quick analysis of multiple samples on microprinted platform.
Analysis of Writing Errors on the Abstracts Submitted for the Research Conferences Hosted by Arsi, Jimma and Wellega Universities
Authors: Idao Bashir
Published: March 2023

The objective of this study was to analyze writing errors on the abstracts submitted for the research conferences hosted by Arsi, Jimma and Wellega Universities. The study used qualitative research method and case study design. The data collection tools were document review and interview. The study used purposive and availability sampling techniques. Findings revealed the common writing errors were grammar, subject-verb-agreement, spacing and mechanics (spelling, capitalization and punctuation). The basic causes for the errors were lack of knowledge of English, lack of attention given to the language and lack of practice of editing own writings. The strategies to mitigate writing errors were through practice of proofreading and editing of own writings before submission. The data from table 5 showed as the highest writing errors were made on grammar (31.8%), spacing (28.2%), subject-verb-agreement (27.3%), spelling (26.4%), capitalization (6.4%) and punctuation (4.5%) respectively. Thus, the study recommends the researchers/authors of the abstracts to deeply scrutinize their English language on the above identified errors, give due attention to the rules and grammar of the language and develop the practice of editing own works before submission. Likewise, it is better to work together with colleagues who are better in English language, have the practice of editing own works and ready to admit comments and feedbacks given to learn from the errors committed. In addition, Ethiopian universities should do on their lecturers/researchers English language competencies to fill their language skill gaps via short term training.
WITHDRAWN: Transdifferentiation of Human Neonatal Foreskin Fibroblasts into Keratinocyte-like Cells via Regulating the AKT/P53/WNT/LEF1 Axis
Authors: Zhao Hongqing , Luo Peng , Liu Xinzhu , Sun Jiachen , Li Zhisheng , Zhang Kun , Shen Chuan’an
Published: March 2023

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been
withdrawn from the journal Current Stem Cell Research & Therapy.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham editorial policy on article withdrawal can be found at https://benthamscience.com/pages/editorial-policies-main

BENTHAM SCIENCE DISCLAIMER:

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and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate
action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors
agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.
Adaptive Event-triggered Sliding Mode Control for Spacecraft Attitude Tracking
Authors: Zhang Jianqiao
Published: March 2023

The spacecraft attitude tracking control problem with limited communication is addressed by employing event-triggered based sliding mode control theory. The attitude dynamics are directly developed on the Special Orthogonal Group SO(3), and singularities and ambiguities associated with other attitude representations are avoided successfully, taking model uncertainties and external disturbances into consideration. Based on the developed model, an adaptive eventtriggered sliding mode controller is designed to ensure the closed-loop system that is uniformly ultimately bounded, by using fuzzy logic theory to deal with the disturbance. Due to the application of the event-triggered theory, the control signal is only updated and transmitted at some discrete instants. Therefore, the communication burden is decreased significantly. Finally, numerical simulations are conducted to demonstrate the effectiveness of the proposed control method.
Attitude Stabilization of Flexible Spacecraft Using Output Feedback Controller
Authors: Yang Ziyu , Yue Xiaokui , Liu Chuang
Published: March 2023

Spacecraft in space may have some certain non-cooperative characteristics due to the service life limit, fuel exhaustion, component fault, structural fatigue damage, or after performing certain space tasks such as capturing non-cooperative targets. In modeling, these non-cooperative characteristics are often manifested in uncertain and unknown inertia, model parameters uncertainty, actuator faults, etc. In this paper, aiming at the attitude stability control problem of such flexible spacecraft, the attitude dynamics modeling is completed by introducing the nominal inertia to construct the comprehensive disturbance term including external disturbance, inertia uncertainty and actuator failure. Then, a static output feedback (SOF) controller is applied to model the closed-loop attitude control system a stable negative imaginary (NI) system with H∞ performance constraints according to NI theory. As long as the optimization variables approach zero, the LMI-based iterative algorithm can find such the static output feedback controller to stabilize the flexible spacecraft. It is worth mentioning that an event-trigger mechanism is introduced into the control scheme to reduce communication pressure. Finally, the numerical simulation is carried out in the presence of controller gain perturbations and model parameter uncertainty. The results of the simulation demonstrate the effectiveness, robustness and non-fragility of the control method.
Targeted Nanocarriers-based Approach For Prostate Cancer Therapy
Authors: Garg Ashish , Madamsetty Vijay Sagar , Ashique Sumel , Gauttam Vinod , Mishra Neeraj
Published: March 2023

Prostate cancer is the most common malignancy in men, with elevated
morbidity and mortality. The current management, along with dope, leads to chemo
defiance. On molecular imaging, many researchers have assisted with staging,
restaging, early diagnosis, and, particularly, prostate cancer healing. At the site of
cancer, treatment of prostate cancer, including chemo, has encountered many
difficulties, such as quick clearance of dope or defiance of drug and short
accumulation. Nanotechnology applications and their use in biomedicine to deliver
various therapeutic carriers fitted to relieve deputy chemotherapy for cancer treatment.
The tumor-targeted dope delivery-related carriers are outlined for prostate cancer
healing. Among them, the developing nanotechnology has introduced several
innovative new testing technologies, and medications for prostate cancer
nanotechnology can significantly increase the management operation of prostate cancer
by using specific physical and chemical properties, targeting techniques, or anchoring
with imaging / pharmacological substances to provide an innovative theranostics
device. This chapter focused on the ultra-modern outgrowth in the observation of
nanomaterial and the identity of prostate cancer, including the representation of modes
used to point biomolecules operationalization and the various prostate cancers along
with nanoparticles, multifunctional nanoplatforms, and nano-related methods of dope
delivery in the administration. 
Cancer Drug Products Containing Nano-materials: Key Regulatory Issues
Authors: Mathew Jinu , Namdeo Pallav , Garg Ashish
Published: March 2023

Nanoparticles are expected to have a broad array of applications, ranging from delivery of therapeutic agents to bio-imaging and, quite lately, personalized treatments, due to their diameter ranging (1-100 nm), which coincides with fundamental biomolecules, such as Genetic material (DNA), significantly increased surface area (1000 m2/g), and remarkable mechanical, electrical, magnetic and photonic characteristics. The capacity to deliver targeted anti-cancer drugs to tumors, cancer detection, their capability to contain hundreds of pharmaceutical units, and their ability to resist dispersion, stability, and tolerance difficulties are all significant benefits of employing nanoparticles as a transporter for chemotherapeutics. Numerous nanomaterials and therapeutic & diagnostic compounds are now conducting clinical tests, and a couple has already received regulatory approval. The “Enhanced Permeation and Retention Effect”, a distinguishing trait of tumor cells, is used to promote controlled administration of chemotherapeutic agents. In contrast to passive targeting, depending on size, the surface of the nano-materials may be changed with a range of ligands that bind with particular receptors highly expressed on the membrane of tumor cells, resulting in precise active targeting. Yet a novel technique for site-specific delivery is using environmental stimulation like heat to a thermo-responsive apparatus to deliver a medicine encapsulated in a nanosized structure at a specified location. This chapter offers information on accepted tumour nanoparticles, such as Oncaspar, Daunoxome, Doxil, Abraxane, and DepoCyt, as well as nanoplatforms utilizing albumin nanospheres, lipoplexes, lipid nanoparticles, liposomes, micelles and gold nanoparticles, which have attained an advanced level of clinical testing.
Exogenous Lipoid Pneumonia
Authors: Effendi Tiar Oktavian , Setyawan Ungky , Putra Ngakan , Erawati Dini
Published: March 2023

Background : Lipoid pneumonia is a rare disease and usually reported as sporadic cases. Exogenous lipoid pneumonia is a more common form of lipoid pneumonia. Untypical characteristics makes incidence rate of this cases are often imprecise. The diagnosis is made from a history of lipid containing material aspiration, radiologic imaging, and histopathological examination. There is no treatment of choice because diagnosis of this cases are rarely made.

Case Report : We report one case at Dr. Saiful Anwar hospital, a 35 years old man with accidental kerosene ingestion and aspiration. Based on examination of the patient, laboratory results, radiological imaging, and BAL fluid analysis and cytology, diagnosis of exogenous lipoid pneumonia was made. Our treatment of choice was combination of antibiotic, corticosteroid and BAL to manage this patient. After 2 weeks of treatment, there were improvements on clinical and radiological imaging.

Conclusion: Exogenous lipoid pneumonia is a rare disease. Using antibiotic, corticosteroid, and BAL through bronchoscopy can be a therapeutic option that provides clinical and radiological improvement.

Key words : Lipoid Pneumonia, Exogenous Lipoid Pneumonia, Treatment of Lipoid Pneumonia
Thymoma (Case Report): Importance of Comorbidity, Lifestyle, and Thymoma Size in Treatment Success
Authors: Suryaman Rachmat , Djajalaksana Susanthy , Setyawan Ungky , Wardhana Koernia , Erawati Dini , Yudhanto Hendy
Published: March 2023

Thymoma is a rare malignancy with an incidence of 0,15 case per 100.000 population and is the most commonly diagnosed anterior mediastinal malignancy. With 12,5% 15-year survival rate, and is often accompanied by autoimmune disease such as myasthenia gravis, pure red blood cell aplasia, and hypogammaglobulinemia, better understanding of factors affecting prognosis is needed to improve patient quality of life and survival.
A 30-year-old Woman with Multiple-Sites Metastasis Lung Adenocarcinoma and Coronavirus-19 Disease (COVID-19)
Authors: Naftali Yokanan , Sugiri Jani Jane Rosihaningsih , Pratiwi Suryanti Dwi , Yudhanto Hendy Setyo
Published: March 2023

Background: Adenocarcinoma is the most common Non-Small Cell Lung Cancer (NSCLC) in non-smokers in Indonesia. It often metastasizes in multiple sites. Metastasis is a negative predictor for prognosis in lung adenocarcinoma. In this covid pandemic era we present a case of a 30-years-old woman with adenocarcinoma and multiple-sites metastasis, and Coronavirus-19 Disease (COVID-19).

Case: A 30-year-old woman came to our hospital with multiple complaints of hearing loss, visual loss, and occasional shortness of breath. The patient had a history of wild-type EGFR adenocarcinoma and has been treated with 4 cycles of gemcitabine. She also presented with a lump in her neck. Further examination revealed multiple metastasis tumours in her brain, right eye, neck, and spine. Pleural fluid examination also showed a malignant pleural effusion. Nasopharyngeal swab using reverse transcriptase-polymerase chain reaction (rt-PCR) method revealed that she also suffers from COVID-19 with positive swab result. Despite adequate treatment, she rapidly deteriorates and passed away in hospital.

Discussion: Management in this patient is complex due to multiple complications and limitation of management given in COVID-19 isolation ward. She presented with multiple equally complicated metastasis, in which treatment priority should be carefully assessed. Despite treatment by multiple specialists, her problems still persist and proved to be fatal.

Conclusion: Although metastasis is common in adenocarcinoma, multiple metastasis is uncommon, and this case highlights the need of careful management priority in such patients in COVID-19 pandemic setting.

Keywords: Adenocarcinoma, Multiple Metastasis, Lung Cancer, COVID-19
Lexicale achterstand van kinderen met farmacoresistente epilepsie is leeftijdsafhankelijk - Een onderzoek naar benoemen van afbeeldingen
Authors: De Koning Trudi , Versnel Huib , Meekes Joost , Braams Olga , Jennekens-Schinkel Aag
Published: March 2023

Achtergrond en doel
Kinderen met epilepsie scoren bij taalonderzoek meestal significant lager dan gezonde leeftijdgenoten. Tot beter begrip hiervan vergeleken wij kinderen met farmacoresistente epilepsie met gezonde leeftijdgenoten in een benoemtaak als index van het lexicon. Onderzoeksvragen waren: verschillen de groepen in aantallen goede benoemingen en/of in hoeveelheid baat bij geboden hulp; hebben verwervingsleeftijd en gebruiksfrequentie van de woorden (namen van de afgebeelde voorwerpen) invloed; zijn de verschillen door de kindertijd heen gelijk; en is invloed vaststelbaar van epilepsievariabelen, demografische variabelen (leeftijd, geslacht, intelligentiequotiënt), en van de omgevingsvariabele opleiding van de ouders.
Methode
Vijfenveertig kinderen met farmacoresistente epilepsie (leeftijd 3,4 - 17,9 jaar; 20 meisjes) en 86 gezonde, per patiënt op geslacht en leeftijd gematchte kinderen/jongeren benoemden lijntekeningen van voorwerpen die verwezen naar vroeggeleerde hoogfrequente (VH), vroeggeleerde laagfrequente (VL) en laatgeleerde laagfrequente woorden (LL).
Bij een willekeurig deel van de onjuiste of uitblijvende benoemingen gaf de onderzoeker hulp door een vraag te stellen naar de functie van het afgebeelde voorwerp. Als dat niet hielp, volgde een fonologische aanwijzing. Goede benoemingen en baat bij de hulp werden per categorie woorden geanalyseerd. Groepsverschillen werden niet-parametrisch getoetst. Exploratief werden met lineaire regressie ziekte- en andere invloeden geanalyseerd.
Resultaten
Er was geen significant verschil in de percentages epilepsie- en controlekinderen die direct alle plaatjes goed benoemden. Ook de percentages kinderen die baat hadden bij hulp verschilden niet significant tussen beide groepen. Wel waren de gemiddelde benoemscores van de kinderen met epilepsie lager dan die van de controlekinderen. Dit groepsverschil verdween met toenemende leeftijd in de VH- en VL-woorden maar niet in de LL-woorden. De baat bij hulp nam in beide groepen toe met de leeftijd als het ging om VH- en VL-woorden. Voor LL-woorden toonde de epilepsiegroep minder leeftijdgebonden toename. Hoe vroeger in het leven de epilepsie was ontstaan, des te zwakker was het benoemen van de plaatjes die verwezen naar LL-woorden.
Conclusie
Kinderen met farmacoresistente epilepsie kunnen hun achterstand in ontwikkeling van het lexicon althans voor vroeg geleerde woorden inhalen. Ook bij kinderen met epilepsie stimuleert hulp (i.c. vragen naar de functie van het voorwerp of een fonologische aanwijzing) het zoeken in het lexicon.
Association of nurses' mental well-being and professional quality of life (ProQOL) to their resiliency during the COVID-19 pandemic crisis
Authors:   Nursing Department, College of Applied Medical Sciences, Majmaah University, Majmaah 11952, Al Majma'ah, Saudi Arabia, Alrasheadi Bader A.
Published: March 2023

This study was conducted in determining the factors that affect nurses’ resiliency while working in public hospitals during the COVID-19 pandemic. A cross-sectional design was used and self-administered surveys were completed by 420 nurses. Nurses working in public hospitals have had high levels of resilience and mental well-being during the outbreak of the COVID-19 pandemic, with their ProQOL found to be average. Higher levels of mental well-being and ProQOL contributed to developing better resiliency. The study poses the significance of taking preemptive measures on the parts of both the government and the healthcare institutions themselves to assist nursing professionals in enduring disasters such as the pandemic.
Antiferrodisorsion transition and dielectric relaxation in SrTiO-=SUB=-3-=/SUB=--SrMg-=SUB=-1/3-=/SUB=-Nb-=SUB=-2/3-=/SUB=-O-=SUB=-3-=/SUB=-
Authors: Smirnova E. P.  , Zaitseva  N. V.  , Guk E. G.  , Sotnikov A. V.
Published: March 2023

Dielectric and acoustic studies of solid solutions were carried out (1-x)SrTiO3-xSrMg1/3Nb2/3O3. The dependence of the temperature of the antiferrodisorsion phase transition on the concentration x of the second component is obtained. The suppression of dielectricrelaxation at x≤0.03 and temperatures below the temperature of the antiferrodisorsion transition, as well as the coexistence of dielectric relaxation and antiferrodisorsion instability at 0.03<x≤0.15. The reasons for the blurring of the dependence of the relative speed of sound in the transition region and the features of the interaction of antiferrodisorsion instability and the dielectric subsystem are discussed. Keywords: antiferrodisorsion transition, dielectric relaxation, acoustic properties. Keywords: antiferrodisorsion transition, dielectric relaxation, acoustic properties.
Structure formation processes in fullerene mixtures
Authors: Khusnutdinov R.M.  , Khairullina R.R.
Published: March 2023

Glass formation processes in condensed matter are characterized by some specific short-range order changes in the arrangement of particles (atoms/molecules/ions). So, the short-range structural order in supercooled liquids and glasses is characterized by fivefold symmetry in the arrangement of particles, often referred to as icosahedral (ideal or distorted) short-range order. This article is devoted to the study of local structural features of the supercooled melt of the A20B80 fullerene mixture (where A = C60 and B = C70) obtained under various cooling protocols in order to elucidate the mechanism of formation of the icosahedral short-range order in binary molecular liquids. Comprehensive studies of the properties of a fullerene mixture melt were carried out using large-scale molecular dynamics simulations followed by structural and cluster analysis. The crystallization temperature and the critical glass transition temperature of the system were calculated to be T_m~1439 K and T_c~1238 K, respectively. It has been established that the crystallization of a binary fullerene mixture proceeds according to the polycrystalline scenario with the formation of clusters with fcc and hcp symmetries. It is shown that in a supercooled fullerene mixture, the short-range icosahedral order is formed by an insignificant number of ideal icosahedral clusters and a certain set of distorted icosahedral clusters, the fraction of which remains practically unchanged at temperatures below the critical glass transition temperature. Keywords: molecular dynamics, fullerenes, short-range order, structural ordering.
Do Antioxidants Extend Longevity in Invertebrate and Vertebrate Animals?
Authors: Badwan Sami , Bailey Elizabeth , Harper James M.
Published: March 2023

In the 1950’s Denham Harman proposed the Free Radical Theory of Aging whereby species lifespan and individual longevities are the consequence of free radical driven damage to biomolecules. This led to decades of research to ascertain the effect of altered antioxidant defense systems on aging and mortality in an array of species using reverse genetics and dietary manipulation. Within invertebrates, the data generally support the Free Radical Theory in that overexpression of antioxidant enzymes or dietary supplementation with antioxidant compounds increases longevity and resistance to oxidative damage. Likewise, genetic knockdown of antioxidant defenses generally shortens longevity within invertebrates. On the other hand, for endothermic vertebrates (i.e., birds and mammals) the results have been equivocal. Downregulation of antioxidant enzymes typically results in an increased oxidative burden, but without an appreciable effect on longevity, while dietary supplementation with antioxidants has little-to-no effect, at least at the concentrations used. Upregulation of antioxidant enzyme genes also fails to increase longevity in vertebrates most of the time. Interestingly, manipulating antioxidant defenses in fishes increases longevity in conjunction with reduced oxidative damage akin to what is seen in invertebrates. Since invertebrates and fishes are both exothermic this raises the possibility that the evolution of endothermy interferes with the ability of antioxidants to slow the aging process.
360° Diagnostic Tool to Personalize Lifestyle Advice in Primary Care for People With Type 2 Diabetes: Development and Usability Study
Authors: Harakeh Zeena , de Hoogh Iris M , van Keulen Hilde , Kalkman Gino , van Someren Eugene , van Empelen Pepijn , Otten Wilma
Published: March 2023

Background

Various multifaceted factors need to be addressed to improve the health and quality of life of people with type 2 diabetes (T2D). Therefore, we developed a web-based decision support tool that comprises a more holistic diagnosis (including 4 domains: body, thinking and feeling, behavior, and environment) and personalized advice. This 360° diagnostic tool enables people with T2D and health care professionals at the general practice to obtain an overview of the most important T2D-related issues and, subsequently, determine the most suitable intervention for the person with T2D.

Objective

This study aimed to describe the systematic and iterative development and evaluation of the web-based 360° diagnostic tool.

Methods

We defined the requirements for the web-based 360° diagnostic tool based on previously developed tools, a literature review, and inputs from a multidisciplinary team of experts. As part of the conceptualization, we defined 3 requirements: diagnostics; feedback; and advice, consultation, and follow-up. Next, we developed and designed the content for each of these requirements. We evaluated the diagnostic part of the tool (ie, measurement instruments and visualization) with a qualitative design, in a usability study with a think-aloud strategy and interview questions, among 8 people with T2D at a Dutch general practice.

Results

For each of the 4 domains, specific parameters and underlying elements were selected, and measurement instruments (including clinical data and questionnaires) were chosen. Cutoff values were defined to identify high-, middle-, and low-ranking scores, and decision rules were developed and implemented using R scripts and algorithms. A traffic light color visual design was created (profile wheel) to provide an overview of the scores per domain. We mapped the interventions that could be added to the tool and developed a protocol designed as a card deck with motivational interview steps. Furthermore, the usability study showed that people with T2D perceived the tool as easy to use, useful, easy to understand, and insightful.

Conclusions

Preliminary evaluation of the 360° diagnostic tool by experts, health care professionals, and people with T2D showed that the tool was considered relevant, clear, and practical. The iterative process provided insights into the areas of improvement, which were implemented. The strengths, shortcomings, future use, and challenges are also discussed.