bluuebunny/crossref_metadata_2025 huggingface dataset:
Digital Marketing Development Strategy of Cocoa Products
Authors: Adha Wahyu Maulid , Mas'ud Anis Anshari , Erwin
Published: March 2024

Purpose: In the context of the issue regarding the implementation of digital marketing strategies for cocoa businesses in West Sulawesi Province, Indonesia, there is a need for an analysis to develop effective solutions. This research aims to analyze the appropriate digital marketing strategies for cocoa product businesses to access a broader market, including the international market.
 
Method: This research employed a qualitative exploratory approach, gathering data through in-depth interviews with relevant stakeholders, data collection, data reduction, data presentation, and drawing conclusions. We adopted the Miles and Huberman model, which is commonly utilized in the data analysis process for qualitative research.
Result and Conclusion: The research findings reveal three primary approaches to developing digital marketing strategies for international market access: (1) Enhancing the readiness of business actors in formulating strategies through digital platforms, such as utilizing websites and social media; (2) Aligning the appropriate international marketing mix, including innovation and creativity in presenting products; (3) Designing a digital marketing framework that aligns with web-based Key Performance Indicators (KPIs).
 
Research Implications: These findings enhance cocoa product business operators' understanding of what is required to implement digital marketing strategies and appropriate international marketing mix in the global market.
 
Originality/value: This study introduces a novel, more intricate model compared to previous research. It emphasizes the necessity of reassessing the international marketing mix within the current landscape of digital transformation. Additionally, it addresses a research gap by focusing on antecedents preceding the adoption of digital marketing, while also exploring the post-adoption experiences of digital marketing, a facet that has received limited attention in prior studies.
Examining the Relationship Between Financial Knowledge, Risk Tolerance, and Past Behavioural Bias on Investors Actual Investment Behavior
Authors: D. Yuvaraj , Venugopal Pulidindi
Published: March 2024

Purpose:  The present study aims to determine the factors influencing investment intention and actual investment behaviour in mutual funds. The study uses financial knowledge and risk tolerance as moderators and past behavioral bias as a mediator.
 
Theoretical framework:  The Theory of Planned Behaviour (TPB) appears to have become a very useful model for predicting various investing behaviours. Therefore, the present utilises the TPB model to analyse mutual fund investment behaviour.
 
Design/methodology/approach:  The convenience sampling method was used to collect respondents from a population of 582 retail investors through questionnaire survey This research used partial least squares structural equation modelling (PLS-SEM) as the main method of data analysis using SmartPLS 4.
 
Findings:  Attitude, financial knowledge, and risk tolerance emerged as the most important determinants of mutual fund investment intention. This highlights the significance of creating favorable conditions in terms of accessibility, which may encourage and ease the decision of investors to purchase mutual funds.
 
Research, Practical & Social implications:  Marketers can explain how their mutual fund offerings would help both the market and investors. Marketers should prioritize proper communication about the benefits of mutual funds to investors, as communication is regarded as a critical tool for the success of mutual fund products.
 
Originality/value:  To understand individual investors' intentions to engage in mutual funds, the impact of attitude, subjective norms, and perceived behavioural control on investor intentions and, actual investment behaviour were hypothesised and analysed, financial knowledge and risk tolerance functioning as moderators. Additionally, past behavioural bias is a mediator.
The Role of Company Reputation as a Moderating Variable in The Relationship Between CSR and Firm Performance
Authors: Juniarti  , Nathania Caroline , Krisnanda Adetya
Published: March 2024

Purpose: This study focuses on whether the company's reputation moderates the role of CSR in improving financial performance.
 
Method/Design/Approach: This research was conducted on companies that follow the Corporate Image Index (CII) 2015-2019 and are listed on the Indonesian Stock Exchange. A company's CII score indicates its reputation level. A total of 180 observations met the research sample criteria.
 
Results and Conclusion: The results indicate that CSR has no direct relationship with good financial performance. However, reputation has a positive effect on financial performance. It has been proven that the more reputable a company is, the stronger its appeal to improve financial performance. Interestingly, when CSR is moderated by reputation, it shows a positive relationship with financial performance.
 
Research Implications: These results contribute to fixing previous findings by confirming the role of a firm's reputation in the association between CSR and firm performance. Therefore, ignoring a firm's reputation will mislead the conclusion of the benefits of CSR.
Transformation of Traditional Islamic Education: Dayah as a Modern Educational Institution in Post-Conflict Aceh
Authors: Erawadi Erawadi , Setiadi Fadlan Masykura
Published: March 2024

This study explored the transformation of Dayah institutions in Aceh, focusing on their change from traditional religious schools to a modern Islamic educational institutions, particularly in the post-conflict era. The integration of modern education into Dayah has sparked a dynamic contestation between tradition and modernity, reflecting broader social and political changes in Aceh. This study also emphasized Dayah's resilience and continued influence on post-conflict reconciliation and contemporary religious practices in Aceh. Meanwhile, this research employed qualitative research with a type of literature review. The findings showed that the transformation of Dayah has formed an integrated educational system that combines traditional Islamic teachings with modern education, fostering the development of science and technology. The Dayah system has successfully cultivated a society with a profound, comprehensive understanding of Islam and has contributed to the cultivation of tolerant individuals by alienating students from radical thought patterns.
Reconstruction of Tafsir Learning in Dayah Aceh
Authors: Anshari Ismail , Rijal Fakhrul , Amin Maimun Abdurrahman
Published: March 2024

Dayah or pesantren as a traditional Islamic educational institution that has given birth to many Acehnese scholars. The existence and number of dayah in Nanggroe Aceh Darussalam is increasing. However, the fact is not balanced with innovations in learning methods, especially interpretation learning. This study aims to provide a detailed picture related to tafsir learning in Dayah Aceh. This research uses qualitative methods with a library research approach. Based on the results of the study, it was found, among others, that the learning of interpretation of most of Dayah Aceh uses the qodim (non-classical) system so that the role of students is limited. The existence of this phenomenon requires the reconstruction of interpretive learning in Dayah Aceh through the use of discovery or inquiry-discovery learning strategies; mastery of learning strategies; Unit Learning Strategies and Reception Learning Strategies
Evaluasi kegiatan seleksi koleksi perpustakaan sebagai pemenuhan kebutuhan informasi dosen di lingkungan UIN Imam Bonjol Padang
Authors: Husnah Husnah , Latifa Maizi
Published: March 2024

Lecturers are involved in the collection selection process prior to procurement. There are various ways of selecting collections such as using publisher catalogs, publisher websites, user suggestions, google forms, syllabus. The purpose of this study was to find out the collection selection process carried out by the Library UPT UIN Imam Bonjol Padang, the response of lecturers in the selection process, and the fulfillment of lecturers' information needs regarding the selection results. This research is descriptive quantitative in nature. The author will describe the collection selection process along with lecturer responses and to fulfill information needs. Then the number of fulfillment of lecturers' information needs on collection proposals is described in percentage form. The results showed that only a small proportion of lecturers (12.2%) of the participating lecturers responded to the collection proposals by filling out the Google form, Google Doc, document files, syllabus delivery and course distribution. UPT Library UIN Imam Bonjol Padang can fulfill most (73.5%) of the proposed collection. Libraries need to increase promotion related to proposing collections to lecturers. Collaboration with the academic and student affairs divisions as well as TIPD needs to be improved to obtain syllabus data and distribution of courses for collection selection
Kajian pemanfaatan teknologi motion capture dalam melestarikan tarian budaya nusantara
Authors: Ratmono Damaji
Published: March 2024

This article discusses methods for preserving Indonesian dances in Indonesia using motion capture technology. Indonesian archipelago dances such as the Khas Semarangan dance, Topeng Cirebon, and Lengger Lanang have had their movements recorded using motion capture. This article discusses how this dance is preserved using motion capture technology along with its advantages and disadvantages.  This article aims to determine the advantages and disadvantages of motion capture technology in preserving Indonesian dances in Indonesia.  This research is literature review research and the method used is literature study. The preparation of this literature review research used several national journals and media reports. Literature collection was carried out using the Google Scholar search engine.  The results obtained are that motion capture technology can be used as an introduction tool, basic learning, and as a reference for learning dance, especially the Semarangan Typical dance, Cirebon Mask, and Lengger Lanang. Motion capture technology can also produce dance simulation game applications. Apart from that, there are seven advantages and seven weaknesses in preserving Indonesian dance using motion capture technology. Preserving and documenting traditional Indonesian dances digitally using motion capture technology is very possible while still considering the existing advantages and disadvantages.
Analisis bibliometrik tren publikasi topik penelitian preservasi audiovisual pada database Scopus tahun 2018 – 2023 menggunakan VOSviewer
Authors: Wardhana Arya Wijaya Pramodha , Salim Tamara Adriani , Sugihartati Rahma
Published: March 2024

This research is intended to examine the development of audiovisual preservation research topics, with the aim of finding out: (1) How the trend of international scientific publications on the topic of audiovisual preservation is developing in 2018 - 2023 on Scopus; (2) What is the distribution of core research journals on the topic of audiovisual preservation in 2018 - 2023 on Scopus; (3) What is the map of the development of international research publications on the topic of audiovisual preservation based on keywords in 2018 - 2023 in Scopus. Data collection by searching through Scopus with keywords and filtering data according to needs. Subjects are explained and visualized with Microsoft Excel, Scopus Results Analyzer and VOSviewer. The research results show that the trend in the development of audiovisual preservation topics from 2018 to 2023 on Scopus peaked in 2022 with a total of 161 articles. Meanwhile, the publisher of the Inti Journal in first place is the Professional Journal De La Información which published 19 articles on the topic of audiovisual preservation, and Spain is the country with the largest number of published articles with 240 articles or (33.76%). For further research, researchers can provide suggestions that it is necessary to add keywords so that the research results obtained can be more accurate, richer and comprehensive.
Tren skripsi mahasiswa Program Studi Pendidikan Islam Anak Usia Dini (PIAUD) UIN Saizu Purwokerto 2018-2022
Authors: Antasari Indah Wijaya
Published: March 2024

The Bachelor's program in Early Childhood Islamic Education (PIAUD) at UIN Saizu Purwokerto was established in 2014. Student theses for the PIAUD program began appearing in the UIN Saizu repository in 2018. The research objective is to describe the research trends in the theses of PIAUD students at UIN Saizu Purwokerto from 2018 to 2022. This study is done using a quantitative approach through bibliometric analysis. The application used for data mining is Zotero, and data visualization is carried out using VOSviewer version 1.6.18. The thesis data source is from repository.uinsaizu.ac.id, with a total of 272 theses processed. The research results indicate that the trends in the themes of the theses by PIAUD students at UIN Saizu Purwokerto from 2018 to 2022 align with the program's focus, revolving around early childhood themes, optimization, and creativity development. Four (4) clusters were formed. No words or phrases indicating a concentration on Islamic Education were observed in the titles of the theses by PIAUD students at UIN Saizu Purwokerto. However, one word in the cluster indicates an Islamic theme, which is the word "RA" (Raudhatul Athfal), representing Islamic educational institutions at the early childhood level.
STRATEGI PENGEMBANGAN MASYARAKAT BERBASIS BUMDES
Authors: Intan Fikri Dina
Published: March 2024

Badan Usaha Milik Desa (BUMDes) merupakan salah satu program desa yang sangat penting yang dibuat untuk meningkatkan taraf ekonomi masyarakat pedesaan sesuai dengan kebutuhan dan potensi desa. Badan Usaha Milik Desa (BUMDes) di Balapulang Wetan dinamakan BUMDes Gemilang. Penelitian ini untuk mendeskripsikan strategi pengembangan masyarakat berbasis BUMDes dan untuk menganalisis SWOT pengembangan masyarakat berbasis BUMDes. Penelitian ini menggunakan metode kualitatif dengan pendekatan deskriptif yang menggunakan analisis SWOT (Strength, Weakness, Opportunities dan Threats) untuk menganalisis datanya. Hasil penelitian ini menunjukkan bahwa BUMDes Gemilang memiliki Strength (kekuatan) BUMDes Gemilang letak tokonya strategis serta adanya delivery order sehingga menjadi Opportunity (peluang) BUMDes dan menarik minat masyarakat untuk berkunjung. Weaknesses (kelemahan) yang BUMDes Gemilang miliki yaitu kurangnya sosialisasi dan kurang lengkapnya barang yang disediakan maka akan menimbulkan Threats (ancaman) yakni kalah saing dengan usaha yang sama yang sudah ada diluar BUMDes.
Strategi Pemberdayaan Muzaki oleh Rumah Zakat Cabang Palmerah Jakarta Barat melalui Platform Digital Islamic Style
Authors: Muhtadi Muhtadi Muhtadi
Published: March 2024

Di era Revolusi Industri 4.0 Indonesia telah banyak berubah. Teknologi yang sudah dapat di akses dengan mudah membuat masyarakat semakin nyaman. Tetapi dalam penggunaan internet juga mempunyai sisi positif dan negatif. Masyarakat diharapkan untuk menggunakan internet secara positif yakni memanfaatkan untuk kebaikan sesama manusia sebagaimana yang dilaksanakan oleh Lembaga Rumah Zakat yang telah membuat platform Digital Islamic Style. Platform digital ini untuk kenyamanan Muzakki dalam membayar zakat. Penelitian dilakukan pada platform Digital Islamic Style dalam memberdayakan muzakki untuk membayar zakat secara online, dengan menggunakan metode penelitian kualitatif dalam bentuk studi kasus dan penjelas deksriptif. Hasil penelitian bahwa terdapat strategi yang digunakan oleh Rumah Zakat untuk memberdayakan muzakki dalam membayar zakat secara online dengan tujuan untuk mempermudah muzakki di antara ruang dan waktu.
OPTIMIZING NAHWU LEARNING: COMBINATION OF ELECTRONIC AND CONVENTIONAL MIND MAPPING
Authors: Putra Arifdo , Ritonga Mahyudin , Triana Hetti Waluati
Published: March 2024

Penelitian ini membahas tentang hasil penelitian tindakan kelas yang bertujuan untuk meningkatkan pembelajaran Nahwu melalui kombinasi strategi pembelajaran mind map elektronik dan konvensional. Permasalahan yang diangkat dalam penelitian ini adalah rendahnya pemahaman siswa terhadap materi Nahwu. Sebelum intervensi, tingkat kelulusan siswa hanya 55%. Kombinasi strategi pembelajaran pemetaan pikiran elektronik dan konvensional dirancang dan diterapkan di kelas untuk mengatasi masalah ini. Metode penelitian yang digunakan dalam penelitian ini adalah penelitian tindakan kelas, yang melibatkan sekelompok siswa dalam proses pembelajaran yang berkesinambungan selama beberapa siklus. Hasil penelitian menunjukkan bahwa strategi pembelajaran mind map secara elektronik dan konvensional meningkatkan pemahaman siswa terhadap materi Nahwu secara signifikan. Peningkatan tersebut terlihat dari tingkat penyelesaian yang meningkat menjadi 81% pada Siklus I dan 90% pada Siklus II. Siswa menunjukkan peningkatan dalam kemampuan mereka untuk mengidentifikasi dan menerapkan aturan Nahwu. Selain itu, mereka menunjukkan peningkatan dalam keterampilan komunikasi lisan dan tertulis dalam bahasa Arab. Oleh karena itu, kombinasi strategi pembelajaran mind map elektronik dan konvensional dapat menjadi pendekatan yang efektif untuk meningkatkan pembelajaran Nahwu. Temuan penelitian ini memberikan wawasan berharga bagi para pendidik yang ingin meningkatkan kualitas Nahwu.
Development Of Conventional Savings And Loan Business Activities Into Sharia Savings And Loan Business Activities
Authors: Sova Mohamad Sofan , Firdaus Achmad , Mulyana Rahmat
Published: March 2024

Seeing the potential of the Muslim majority in this country and the euphoria of desire from the leader in the region to apply the Sharia economic principle. However, it is not by the quantity of the successful conversion of the conventional Savings and Loans Business Cooperatives into Sharia Saving and Financing Cooperatives. This research aims to identify problems, formulate solutions, and design strategies for converting conventional Savings and Loans Business Cooperatives into Sharia Saving and Financing Cooperatives. This research uses the Analytic Network Process (ANP) method by collecting opinions from various experts, such as practitioners, regulators, and experts in converting conventional Savings and loan cooperatives into Sharia Savings and loan cooperatives. This research discovers that there were similar opinions on the problems, that internal aspects caused the low conversion rate. Stakeholder interests and human resource needs are the dominant internal problems influencing the most. To solve this problem by processing data from all the respondents based on average results, the priority is the aspect of education and communication. The second priority is the aspect of gradual conversion. The proposed solution will be more effective using a market-driven strategy and rational persuasion. The implication is that the government and other stakeholders can promote the education and communication sector, where education in the form of internships and DPS or Sharia Economics training will have a significant impact.
The Effectiveness Of Village Microfinance Financing Program By Baznas In Encouraging The Development Of Micro-Entreprises
Authors: Jasri Jasri , Wahdah Andi Syarifah , Malik Abdul
Published: March 2024

This research aims to identify how the implementation of the village microfinance program by Baznas affects the development of micro-enterprises owned by the beneficiaries in BAZNAS Maros Regency. The research methodology employed in this study involves a qualitative approach with a descriptive nature. Data collection methods include observations, face-to-face interviews, and documentation. The research findings reveal that the execution of the Village Microfinance program by the National Zakat Agency in Maros Regency significantly contributes to micro-entrepreneurs in enhancing their businesses, especially those facing difficulties in accessing capital. The program also assists micro-entrepreneurs in mitigating the decreased income impacts caused by the COVID-19 pandemic. In addition to financial support, beneficiaries entering the micro-business sector also receive market access support from the BAZNAS Village Microfinance program, aiding them in promoting their commercial products more effectively.
The Influence Of Beauty Influencers, Lifestyle, And Halal Label On The Purchase Decision Of Somethinc Cushion Product
Authors: Fadilla Dina , Sitepu Novi Indriyani , Sari Nurma , Nurlina Eka , Syukri Sarah
Published: March 2024

This study analyzes the effect of Beauty influencers, Lifestyle, and Halal labels on purchasing Cushion Somethinc products. This study uses a quantitative method using a Likert scale. The sample for this study were students of the Faculty of Economics and Business at Syiah Kuala University who used the Cushion Somethinc product. 110 respondents were taken through purposive sampling using the Hair formula. The analytical method used is multiple regression analysis. The results of this study indicate that Beauty Influencer, Lifestyle, and the Halal Label have a positive and significant effect on the decision to buy cushion Somethink products. Beauty influencers are helpful for brands wishing to adopt the marketing strategy for developing local cosmetic products and making lifestyle and halal labels an indicator in purchasing decisions.
A Study On The Positive Impact Of Digital Visibility On Marketing For Micro, Small, And Medium Enterprises
Authors: Aviva Itsla Yunisva , Ardiansyah Mawar , Puspita Widya Husna , Salim Mohammed Salim
Published: March 2024

This study examined the positive impact of the visibility of MSMEs in the digital world on marketing. This study used a qualitative method with a descriptive approach. The data used is secondary data. Data analysis was performed using qualitative analysis techniques. The study results show that the visibility of MSMEs has a crucial role in the sustainability of MSMEs. There are several positive impacts from the emergence of MSMEs in the digital world on marketing, such as: increasing Brand Awareness, making it easier for customers to find information, increasing the number of customers which indirectly can also increase sales and customer loyalty. In addition, there are several strategies that can be used to increase the visibility of MSMEs in the digital world related to marketing, namely building websites, using social media, doing SEO (Search Engine Optimization), creating online advertisements, and getting positive reviews. . By utilizing good digital marketing, MSMEs can more easily promote their products and services to a wider audience. In addition, it can attract more potential customers. This also allows MSMEs to more easily compete with larger companies as they can reach the same audience at a lower cost.
Influential Celebrities In Sustainable Online Shopping: A Theory Of Reasoned Action Insights
Authors: Pane Mujahidun Hapisni , Rukiah Rukiah , Siregar Budi Gautama , Nasirin Wanda Khairun , Hidayat Randi Friscilla
Published: March 2024

ABSTRACTThe implementation of lockdown in 2020 as a response to COVID-19 has led to significant behavioral changes, pushing society to adapt to online transactions. This research aims to analyze the influencing factors such as e-trust, e-wom, e-servqual, and celebrity endorsers on online purchase decisions, as well as examine the moderating effect of celebrity endorsers on these decisions. The research methodology used is quantitative with stratified sampling techniques, employing the Structural Equation Model Partial Least Square (SEM-PLS) with WarpPLS 8.0 software. The results of the study indicate that e-trust and e-WOM have a positive and significant impact on online purchase decisions, while e-service quality does not have a significant influence. Another finding is that celebrity endorsers can moderate e-trust, strengthen consumer trust in online transactions, and impact purchase decisions. However, celebrity endorsers are not effective in moderating e-WOM and e-service quality in online purchase decisions. In this context, e-trust, e-WOM, and celebrity endorsers play crucial roles in influencing online purchase decisions, in line with the Theory of Reasoned Action. The practical implications of this research emphasize the importance of building consumer trust in online transactions and managing the use of celebrity endorsers wisely to enhance purchase decisions. E-commerce companies and online platforms need to provide high-quality services to strengthen consumer trust. Moreover, the role of e-WOM should also be considered to influence purchase decisions and improve online service quality according to consumer expectations. The policy recommendations resulting from this research highlight the need for companies to focus on managing consumer trust and utilizing celebrity endorsers wisely to enhance sustainable online shopping.
Synthesis of a New Series of Chromones Based on Formylthiazoles
Authors: Tarasenko Dmytro O. , Chumak Andriy Y. , Kolomoitsev Oleksii O. , Kotliar Volodymyr M. , Roshal Alexander D.
Published: March 2024

A preparative approach to thiazole-containing chromone derivatives has been developed by modifying the corresponding aldehydes with their further transformation into propenone derivatives, and finally introducing them into the Algar-Flynn-Oyamada reaction. Several methods for obtaining propenones have been analyzed, and the most effective and practically convenient one has been found. The thiazole-containing analogs of chromones obtained have a great potential as probes for a wide range of studies.
An Efficient Synthesis of PARP Inhibitors Containing a 4-Trifluoromethyl Substituted 3,6,7,7a-Tetrahydro- 1H-pyrrolo[3,4-d]pyrimidine-2,5-dione Scaffold
Authors: Lukianov Oleh O. , Tkachuk Viktor M. , Stepanova Diana S. , Gillaizeau Isabelle , Sukach Volodymyr A.
Published: March 2024

Poly(ADP-ribose) polymerases (PARPs) are key enzymes in the DNA repair pathway. Inhibitors of these enzymes belong to a new type of anticancer drugs that selectively kill cancer cells by targeting the homologous recombination genetic defects. This study presents a new synthetic approach to PARP inhibitors containing a 4-trifluoromethyl substituted 3,6,7,7a-tetrahydro-1H-pyrrolo[3,4-d]pyrimidine-2,5-dione scaffold. The method is based on a practical one-step cyclocondensation of 2-(2-oxo-1,2,3,4-tetrahydropyrimidin-4-yl)acetic acid derivatives via the Curtius rearrangement of the corresponding acyl azides formed in situ upon the treatment with diphenylphosphoryl azide. The resulting products have been found to possess a potent inhibitory effect on PARP-1 and PARP-2 isoforms of poly(ADP-ribose) polymerases. The structure–activity analysis has revealed that the N1-aryl substituent is crucial to the selectivity and high potency towards PARP-2, and that the p-fluorobenzyl group is the optimal group for the non-selective and potent PARP-1 and PARP-2 inhibition.
The Synthesis of Functionalized Dimethylphosphinoyl Cyclopropanes and Cyclobutanes
Authors: Aleksandrova Anastasiia M. , Cherednichenko Alona S. , Rassukana Yuliya V.
Published: March 2024

A simple preparative approach to a series of functionalized dimethylphosphinoyl-containing cyclopropanes and cyclobutanes has been developed; it is based on cyclocondensation of dimethylphosphinoyl acetonitrile with 1,2- and 1,3-dibromoalkanes. Synthetic procedures for obtaining nitriles, amines and carboxylic acids containing in their structure small saturated cyclic rings of cyclopropane or cyclobutane and a dimethylphosphine oxide fragment, which are popular in drug design, have been developed.
The Study of Compounds Distilled with Water Vapor in Cetraria islandica (L.) Ach. Thalli Harvested in Ukraine
Authors: Shpychak Alina O. , Khvorost Olga P.
Published: March 2024

The component composition and the quantitative content of compounds distilled with water vapor in the thalli of Cetraria islandica (L.) Ach. harvested in Ukraine were determined using the method of gas chromatography with mass spectrometric detection (GC/MS). 24 compounds distilled with water vapor were identified with the prevalence of fatty acids and their derivatives (57.86±2.00% of the total compounds), terpenoids and their derivatives (23.57±0.97% of the total compounds) and acyclic saturated hydrocarbons (10.99±0.45% of the total compounds). The highest percentage was observed for octadecadienoic (linoleic) acid (20.08±0.67% of the total compounds), hexadecanoic (palmitic) acid (19.21±0.77% of the total compounds) and 9,17-octadecadienal (18.57±0.56% of the total compounds). The presence of 4 monoterpenoids and 6 sesquiterpenoids in the raw material studied was determined for the first time.
Nature-Inspired Tetrahydropentalene Building Blocks: Scalable Synthesis for Medicinal Chemistry Needs
Authors: Smyrnov Oleh K. , Pashenko Olexandr Ye.
Published: March 2024

Inspired by the bioactivity of natural compounds with a bicyclo[3.3.0]octane core, the study focuses on developing tetrahydropentalene-2,5-dione (2,5-THP-dione) derivatives as potential building blocks for the use in medicinal chemistry. Using the commercially available 2,5-THP-dione, a number of alkylated derivatives and a monofunctional ketone were synthesized. Using optimized protocols for synthesis, target compounds were obtained with high yields on a multigram scale. These compounds are promising derivatives for further chemical derivatization and therapeutic use, and thus highlight the value of 2,5-THP-dione in creating complex molecular structures for drug discovery, as well as the importance of tetrahydropentalene derivatives as valuable building blocks in synthetic chemistry.
A pesquisa jurídica no mestrado: uma introdução aos seus fundamentos
Authors: Marques Leonardo , Guimarães Claudio , Lobato Andrea
Published: March 2024

Os cursos de graduação em Direito no Brasil, assim como, os cursos de pós-graduação lato sensu, as também denominadas Especializações, também, na área jurídica, não têm entre suas prioridades a pesquisa acadêmica, jurídico-científica, razão pela qual os alunos que ingressam na pós-graduação stricto sensu, mormente nos cursos de Mestrado, têm muito pouca familiaridade com conteúdos afetos à epistemologia e a metodologia da pesquisa no Direito. A partir de tal percepção, tem o presente artigo o objetivo de apresentar as principais categorias e conceitos ligados a esta temática, de maneira concatenada, conforme desenvolvidos quando do estudo da disciplina, como forma de facilitar a iniciação daqueles que se interessem pela elaboração do conhecimento cientificamente válido.
Inconstitucionalidades intencionais : racionalidade e dinâmica política da câmara legislativa do Distrito Federal
Authors: Silveira e Silva Rafael , Aires de Menezes Júnior Gilson
Published: March 2024

No exercício da função típica do Poder Legislativo, na ânsia de defender ideias e pautas, em muitas ocasiões os parlamentares partem, de forma proposital, para a iniciativa de proposições que facilmente seriam consideradas inconstitucionais, por flagrante vício de iniciativa. Essas “inconstitucionalidades propositais”, ou seja, iniciativas parlamentares eivadas de vício de iniciativa, mas com plena consciência quanto sua inconsistência, são respaldadas tanto pela necessidade de demonstração de conexão com os eleitores, quanto, indiretamente, como movimento estratégico para atrair a atenção do Poder Executivo para se associar à pauta de interesses, incentivando-o a sanear o inconstitucionalidade. Tal movimento se opera por meio do fenômeno da Apropriação da agenda do Legislativo por meio do veto. O artigo apresenta a estratégia política de sanear as “inconstitucionalidades propositais” por meio da associação com a Apropriação da agenda no panorama legislativo do Distrito Federal, contrariando o senso comum de que leis inconstitucionais por vício formal são traço de irresponsabilidades por falta de rigor técnico ou expertise das casas legislativas.
Saúde pública baseada em evidências (SPBE) como conteúdo essencial da política pública de direito à saúde
Authors: Pae Kim Richard
Published: March 2024

O artigo decorre de pesquisa científica realizada sobre a importância da Medicina Baseada em Evidências (MBE) e sua relação com o direito à saúde, indicando que o novo paradigma estabelecido pela MBE exige dos profissionais da área da saúde, gestores e até do Judiciário que as decisões sejam fundamentadas na ciência e nas experiências sistêmicas a garantir os direitos individuais e transindividuais dos cidadãos; e que o nosso regime jurídico estabelece uma vinculação normativa de nossas políticas públicas à denominada Evidence-Based Public Health (EBPH), “Saúde Pública Baseada em Evidências” (SPBE), cujos parâmetros estão moldados em protocolos internacionais, além de exigir que os seus parâmetros técnicos imponham barreiras ao acesso a medicamentos e processos técnicos experimentais no âmbito do SUS.
Analysis of the Use of Graphic, Audiovisual and Computer Media in Indonesian Language Learning in Elementary Schools
Authors: Wulandari Retno , Aminah Siti , Pratiwi Veronica Unun , Nugrahaini Farida
Published: March 2024

This research aims to describe the use of learning media in Indonesian language learning used by teachers and students at SDN Jati 2 Masaran. There is an urgency for learning media in elementary schools in the current digital era. First, using media can create a special attraction in learning. Interesting learning media can provide a pleasant learning experience for effective learning. Learning media can help students understand concepts more easily and quickly. Third, increase student participation. This can increase student involvement and participation in learning. Fourth, increase student creativity. This research method uses a qualitative descriptive research type. Research data comes from observations and interviews with data sources of students and teachers in elementary schools. Data collection techniques through observation, interviews and documentation. The results of the research show that at SDN Jati 2 Masaran teachers have used graphic media in the form of whiteboards, KBBI, puzzles, and charts and audiovisual media in the form of tape recorders, speakers and radio, as well as computer-based media in the form of powerpoint, web-based, and applications. in supporting Indonesian language learning.
Operando Nuclear Magnetic Resonance (NMR) Studies of a Trickle-bed Reactor Using D-T2 Correlations
Authors: Sparks Amy , Gladden Lynn , Brennan Colin , Mantle Mick
Published: March 2024

Catalytic conversions in fine-chemical and pharmaceutical production are increasingly performed in trickle-bed rectors. Optimisation of these processes is usually based on end of pipe measurement made at specific residence times. This process is both time-consuming and the data sometimes challenging to interpret. In the present work, operando nuclear magnetic resonance (NMR) techniques both at the scale of the whole bed (global) and spatially resolved within the bed (local) are used to gain new insights into the catalytic conversion process under reaction conditions. Spatially resolved spectroscopic and diffusion-T2-relaxation (D-T2) methods interrogate local differences in chemical conversion and selectivity, and mass transport (molecular self-diffusion) respectively, thereby providing valuable information for process simulation models. This capability is demonstrated using the continuous flow three phase (gas-liquid-solid) hydrogenation of benzonitrile over a fixed bed of 0.5 wt% Pd/Al2O3 catalyst pellets yielding toluene and benzylamine. Global 1H spectroscopic and D-T2 were used to monitor chemical conversion and the approach to steady state; these were subsequently followed by spatially resolved 1H spectra and spatially resolved D-T2 correlations to examine the local differences in axial conversion and selectivity of the catalyst bed packing. At steady-state a global conversion of 63% was achieved with 65% and 25% selectivity to benzylamine and toluene respectively. Heterogeneities in the local (axial) conversion and selectivity differed by 31% along the total catalyst bed length. These techniques should be applicable to many three-phase heterogeneous catalytic systems provided that the T2 relaxation time of the reactants and products is not prohibitively small.
The pKa Values of Water in Water: A Long-Standing, Tiresome, yet Soon Forgotten Issue?
Authors: Togni Antonio
Published: March 2024

The pKa values of water and the hydrogen ion (proton) in water are 14 and 0, respectively. Yet, many textbooks of general, organic, and, to a lesser extent, inorganic chemistry provide the incorrect values 15.74 and -1.74, respectively. This column briefly introduces the long-standing issue of these two different pairs of values, the consequences it bears when teaching general chemistry, and expresses the hope that it may be solved soon.
Counteranion-Controlled Chemodivergent Transfer-Hydrothiolation/Carbothiolation Utilizing Thioethers as Bifunctional Reagents
Authors: Wang Zhen , Tan Hao-Dong , Wang Yao-Xin , Li Qi , Xue Xiao-Song , Yang Xiao-Hui
Published: March 2024

The pursuit of catalysis capable of forging C(sp3)-S bonds is extremely desired because these bonds have substantial importance in pharmaceuticals, functional materials, and organic synthesis. Hydrothiolation and carbothiolation of feedstock alkenes are among the most straightforward and prominent approaches to C(sp3)-S bond formations. However, hydrothiolation of unactivated alkenes typically proceeds in an anti-Markovnikov fashion, and carbothiolation relied on three-component coupling strategies using highly reactive pre-functionalized electrophilic sulfur sources and nucleophilic carbon sources. While carbothiolation of alkenes with a single, bifunctional reagent represents a concise and streamlined synthetic strategy for -alkyl organosulfur compounds, it has not been reported. Herein, by strategically using heterolytic cleavage of C(sp3)−S bond, we report a chemodivergent transfer-hydrothiolation and carbothiolation of alkenes with thioethers serving as bifunctional reagents. These catalytic systems can control the cleavage and reformation of strong C(sp3)−S -bonds. The chemo-control is achieved through careful selection of the counteranion associated with the Rh-centre. Counteranions with relatively strong basicity and coordinating ability, such as TfO-, promote an unusual Markovnikov transfer-thiol-ene reaction. Conversely, less basic and non-coordinating counteranions, such as BF4-, enable an unprecedented thioether-ene reaction, directly adding thioethers across alkenes. Mechanistic and computational studies elucidated that the coordination or non-coordination of counteranions on Rh can alter the basicity of thiolate, resulting in chemodivergence.
Demographic and Clinical Profile of Oral Submucous Fibrosis: A Retrospective Study
Authors: Moin Iftikhar Shapoo  , Mohammad Yunis Saleem Bhat  , Dheeraj Sharma  , Atoofa Zargar
Published: March 2024

BACKGROUND: Oral Submucous Fibrosis (OSMF) is a potentially malignant disorder which is irreversible in nature and has high morbidity and high malignant transformation rate and hence demands focus on prevention of the disease at population and individual level. AIMS: Assessment of risk factors and the role of habit variables such as duration and frequency in the severity of OSMF and to ascertain the association of gender predilection for different habits and severity of OSMF. MATERIALS AND METHOD: This descriptive retrospective study of 1801 OSMF patients was carried out at the Dental hospital in the rural population of Gwalior region. The clinicodemographic data including details of habits was collected for a period of 5 years, from January 2016 to December 2021. Collected data was analysed using Systat version 12 software. RESULTS: The average age of the patient in the study was 32.8 years, with 16.5:1 M:F ratio. Significantly higher proportions of females (69.6%) were illiterate and belonged to low socioeconomic status. There was a statistically significant increase for areca nut chewing (OR=0.135(0.054-0.342), P < 0.0001), gutkha chewing (OR=22.32(10.421-47.817), P < 0.0001), tobacco chewing (OR= 0.111(0.04-0.308), p<0.0001), smoking habits (OR=30.791(7.472-126.89), P < 0.0001) and alcohol (OR=12.692(3.077-52.347, p < 0.0001) in males when compared with females. The maximum patients were seen in stage II (37%) and stage III (34%), followed by stage I (18.73%) and stage IV (10.3%) and the severity of OSMF was more in subjects who had the habits for longer duration. CONCLUSION: There was a definite gender predilection for various habits and their variables (frequency, duration), educational and socioeconomic status, clinical features and disease severity. Significant correlation was also found between habit variables (duration, frequency) and severity of the disease.
pADP-ribosylation regulates the cytoplasmic localization, cleavage, and pro-apoptotic function of HuR
Authors: Ashour Kholoud , Sali Sujitha , Aldoukhi Ali H , Hall Derek , Mubaid Souad , Busque Sandrine , Lian Xian Jin , Gagné Jean-Philippe , Khattak Shahryar , Di Marco Sergio , Poirier Guy G , Gallouzi Imed-Eddine
Published: March 2024

HuR (ElavL1) is one of the main post-transcriptional regulators that determines cell fate. Although the role of HuR in apoptosis is well established, the post-translational modifications that govern this function remain elusive. In this study, we show that PARP1/2-mediated poly(ADP)-ribosylation (PARylation) is instrumental in the pro-apoptotic function of HuR. During apoptosis, a substantial reduction in HuR PARylation is observed. This results in the cytoplasmic accumulation and the cleavage of HuR, both of which are essential events for apoptosis. These effects are mediated by a pADP-ribose–binding motif within the HuR-HNS region (HuR PAR-binding site). Under normal conditions, the association of the HuR PAR-binding site with pADP-ribose is responsible for the nuclear retention of HuR. Mutations within this motif prevent the binding of HuR to its import factor TRN2, leading to its cytoplasmic accumulation and cleavage. Collectively, our findings underscore the role of PARylation in controlling the pro-apoptotic function of HuR, offering insight into the mechanism by which PARP1/2 enzymes regulate cell fate and adaptation to various assaults.
History of Risky Pregnancies and Failure of Exclusive Breastfeeding in Indonesia
Authors: Simbolon Demsa , Yanti Nur Mahdiyah Merly , Ningsih Lisma
Published: March 2024

The coverage of exclusive breastfeeding for infants in Indonesia still needs to be higher compared to the national target (80%). Low coverage of exclusive breastfeeding is a risk factor for various nutritional problems in toddlers. The causes of failure of exclusive breastfeeding are multifactorial, including risky pregnancy. This study aims to determine the association of risky pregnancies with the failure of exclusive breastfeeding using national data from the 2017 Indonesian Health Demographic Survey (IDHS) with a cross-sectional design. The study sample that met the criteria was 6,689 mothers with children aged 6-23 months. The independent variable is risky pregnancy (parity, pregnancy spacing, age during pregnancy), and the dependent variable is the failure of exclusive breastfeeding. Data analysis using multivariate logistic regression. The results found that only 26.2% of exclusive breastfeeding practices. Risky pregnancy is associated with the failure of exclusive breastfeeding. Mothers with too much parity risked 1,195 times, mothers with primiparous parity risked 1,716 times, too close birth spacing risked 1,210 times, and too young mothers were 1,267 times more likely not to exclusively breastfeed than mothers who had normal pregnancies after controlling for the area of residence. It is necessary to improve health promotion programs to the public regarding the importance of offering exclusive breastfeeding to infants and improving fertility characteristics.
Analysis of Determinant Factors of Chronic Energy Deficiency (CED) in Pregnant Women With Modification of Lawrence Green and Snehandu B. Kar’s Theories
Authors: Yuni Fitria Siska , Suhartini  , Ristya Widi Endah Yani
Published: March 2024

Throughout the world, almost every day, 800 mothers die due to complications of pregnancy and childbirth, and more than 5 million babies die every year. One factor that can increase the risk of maternal and infant death is Chronic Energy Deficiency (CED) during pregnancy. This research aimed to analyse the determinants of CED factors in pregnant women with modifications to Lawrence Green's and Snehandu B. Kar's theories. This research used an analytical survey with a cross-sectional approach. In August–September 2023, there were 97 cases and 97 controls. The sampling technique was purposive sampling—bivariate analysis used chi-square and multivariate with a logistic regression test. The statistical analysis showed that education, gravida, parity, pregnancy interval, and husband's support have a significant relationship with CED (p<0.05). Meanwhile, age, knowledge, occupation, Antenatal care (ANC) examination, intention to become pregnant, independence in making health decisions, the role of health workers, family and health cadre support, transportation facilities, and ease of obtaining health information were not significant relationships to CED (p>0.05). Multivariate statistical analysis showed primigravida was the most dominant factor (p<0.05). The factors of education, gravida, parity, pregnancy interval, and husband's support were significant relationships with CED in pregnant women. The most dominant factor causing CED is primigravida. We recommend providing optimal FE tablets and educating adolescents about the importance of adolescent nutrition and integrated services in the school environment.