bluuebunny/crossref_metadata_2025 huggingface dataset:
Qualidade de aprendizado de alunos em uma faculdade de Medicina durante a Pandemia do COVID-19
Authors: Chan Daniely , Nascimento Khaíza da Vitória , Oppenheimer Drauzio
Published: November 2023

Introdução: O ensino dos alunos da área da saúde durante o período de isolamento social foi constituído de diversas adaptações e inovações, entretanto, os resultados dos anos de estudo remoto ainda estão sendo observados com o retorno da população às atividades coletivas, fazendo-se necessário estudos para avaliar esta questão. Objetivo: Avaliar o desempenho e as dificuldades enfrentadas no âmbito acadêmico durante a pandemia da COVID-19 em uma Faculdade de Medicina do Sul de Minas Gerais. Métodos: Estudo transversal utilizando questionário pré-formulado realizado em uma Faculdade do Sul de Minas Gerais. Resultados: 51% dos alunos discordam que as aulas realizadas online tiveram a mesma eficácia, em termos de conhecimento, que aquelas realizadas presencialmente, 66,7% afirmaram que nível de concentração e rendimento nos estudos não foi o mesmo durante o isolamento social, 54,9% dos alunos se sentem inseguros com o conteúdo aprendido durante a pandemia da COVID-19, 54,9% afirmaram terem apresentado dificuldades de expandir atividades extracurriculares durante o período pandêmico. Conclusão: Percebe-se que as ferramentas disponibilizadas pela faculdade foram úteis e aparenta ter atendido a demanda, porém no que diz respeito a qualidade do aprendizado, esta não parece ter melhorado, uma vez que mais da metade dos participantes da pesquisa se sentem inseguros com o conteúdo abordado de maneira remota, durante a pandemia.
Consequências das dietas da moda na saúde da mulher
Authors: Coelho Alyna Comap , Brandão Elizandra dos Santos , Silva Wilkens Leandro Cardoso da , Freitas Francisca Marta Nascimento de Oliveira , Lobo Rosimar Honorato
Published: November 2023

O artigo visa demonstrar através de uma revisão literária as consequências que as dietas feitas por influência das diversas plataformas de mídias sociais existentes podem impactar na saúde das mulheres, visto que a busca pelo corpo ideal  em um curto período de tempo tem se intensificado cada vez mais, é nítido que  a mídia interfere de maneira significativa nas ações dos indivíduos relacionadas ao comportamento alimentar,  a maioria  deste grupo em questão passa primeiramente pelas redes sociais antes de procurar um profissional que de fato seja habilitado na área, essas mudanças abruptas no comportamento alimentar podem gerar graves consequências tanto físicas, emocionais e psicológicas, podemos destacar como principais os transtornos alimentares, como bulimia, anorexia, baixa autoestima, distorção da autoimagem corporal, podem gerar intolerâncias alimentares que antes não existiam, em alguns casos  podem levar até mesmo ao óbito. A restrição de um ou mais grupos alimentares são comuns nas dietas citadas neste artigo, e na sua maioria essa proibição não possui nenhum respaldo científico. o principal objetivo desta pesquisa é enfatizar que a adoção de dietas populares pelo público leigo, sem a devida orientação de um nutricionista, pode impor riscos e malefícios a saúde, que todo este cenário associado à rapidez de circulação das informações provoca ainda mais o crescimento de distúrbios alimentares e a globalização de padrões de beleza que fogem da realidade de muitas mulheres.
Clinical and ultrasonographic correlation of changes in the equine axial skeleton with thoracic and pelvic lameness detected by objective evaluation
Authors: Bastiani Grasiela de , Azevedo Marcos da Silva , Jacobsen Tainã Kuwer , Rodrigues Ana Paula , De La Côrte Flávio Desessards
Published: November 2023

Cervical and thoracolumbar changes are commonly found in sports animals and may be related to biomechanical alterations, driving movement, and the type of saddle used. The objective of this study was to characterize the correlation between clinical and ultrasonographic findings of the equine axial skeleton with objective evaluation lameness in the thoracic or pelvic limbs. A total of 76 horses of the mounted cavalry with an average of ten years of age, divided between castrated males and females of indeterminate breeds, were submitted to clinical, ultrasonographic and objective evaluations. The evaluated variables were classified in scores from 0 to 4, for later statistical analysis spearman correlation through the RStudio® software. The animals were classified into six groups according to the objective, clinical and ultrasonographic changes. A weak positive correlation was observed between the objective evaluation variable in relation to the clinical (r = 0.1, p > 0,05) and ultrasonographic (r = 0.1, p > 0,05) evaluation variables. In the present study, it was impossible to consider the correlations statistically significant since the p-value was higher than the significance level of 5%. Therefore, the associated evaluation of the axial and appendicular skeleton is of fundamental importance in the clinical routine to investigate musculoskeletal changes. This was demonstrated in the present study, where 68.42% (n=52) presented both clinical and ultrasonographic changes of the axial skeleton concomitantly with thoracic and/or pelvic lameness.
A dieta cetogênica como intervenção para melhoria da qualidade de vida em pacientes diagnosticados com Síndrome de West: Uma revisão sistemática
Authors: Mendes Rayanne da Cunha , Souza Sâmara Pesqueira , Silva Junior Luis Claudio Almeida da , Carvalho Jordy Silva de , Coelho Victor Hugo Oliveira Martins , Horta Wagner Gonçalves
Published: November 2023

O presente estudo tem como objetivo avaliar a eficácia da dieta cetogênica na melhoria da qualidade de vida dos pacientes com Síndrome de West, sobre o controle de espasmos e convulsões, os benefícios de seu uso isoladamente e adjunto às terapias conservadoras, as suas consequências a curto e longo prazo quanto a sua tolerância e os seus efeitos colaterais. Trata-se de uma Revisão Sistemática da Literatura de natureza qualitativa, com estratégia de busca os Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) e avaliação metodológica Critical Appraisal Skill Programme (CASP), analisando-se ao total 6 artigos. Os artigos foram pesquisados nas bases de dados PubMed e SciELO, excluindo revisões simples de literatura. Foram incluídos artigos publicados nos últimos 10 anos (2013-2023) e disponibilizados em inglês. Após análise sistemática dos estudos, depreende-se que a dieta cetogênica mostra-se eficaz na redução de espasmos infantis, principalmente, em casos refratários a tratamentos medicamentosos combinados, além disso os efeitos colaterais e as recaídas ao quadro foram menores do que em pacientes que fizeram uso do hormônio adrenocorticotrófico. A abordagem da dieta Atkins também teve sucesso na suspensão de espasmos. A dieta cetogênica foi bem tolerada, com efeitos colaterais mínimos quando combinada com a Vigabatrina. Efeitos colaterais incluíram aumento de triglicerídeos e corpo cetônico. Espera-se que estudos futuros continuem a destacar os benefícios e melhorias na qualidade de vida dos pacientes com Síndrome de West.
Fatores relacionados à qualidade de vida e sobrecarga dos cuidadores informais de pessoas idosas com demência
Authors: Corral Amanda Curiel Trentin , Oliveira Naila Albertina de , Taminato Mônica , Hino Paula , Okuno Meiry Fernanda Pinto
Published: November 2023

Objetivo: Associar as variáveis referentes à atividade de cuidador com a qualidade de vida e a sobrecarga; e correlacionar a qualidade de vida com a sobrecarga dos cuidadores informais de pessoas idosas com demência. Metodologia: Pesquisa online e transversal, com 112 cuidadores familiares de pessoas idosas com demência, entre os meses de novembro de 2021 e julho de 2022. Aplicados: questionários sociodemográficos; clínicos; atividade de cuidador; Questionário de Avaliação da Sobrecarga do Cuidador Informal e Qualidade de Vida Controle, Autonomia, Autorrealização e Prazer. Foram realizadas a análise descritiva, a correlação de Spearman e o post-hoc de Bonferroni. Resultados: Para a qualidade de vida, observou-se se uma correlação negativa de nível moderado para sobrecarga (ρspearman = -0,656; p < 0,01). Cuidadores que exerciam atividade remunerada (36,3 ± 3,03) e que se sentiam valorizados (38,8 ± 3,12) apresentaram escore maior de qualidade de vida. Aqueles que não exerciam atividade remunerada (90,3 ± 5,82) e que não se sentiam valorizados (77,3 ± 5,39) apresentaram maior sobrecarga. Conclusão: Quanto maior o escore de sobrecarga, mais baixo o escore de qualidade de vida. Exercer atividade remunerada e se sentir valorizado associou-se a um escore maior de qualidade de vida. Não exercer atividade remunerada e não se sentir valorizado associou-se a maior sobrecarga.
Evidências acerca da associação causal entre hipotireoidismo e depressão
Authors: Brito Luana Mesquita , Carvalho Bruna Damas de , Vasconcelos Milena Bentivoglio Cunha Naves , Oliveira Lizandra Gomes de , Martins Matheus Vaz , Medeiros Thaisa , Torrico Gabriel Rosa , Rodrigues Gabriella Leon , Kitahara Fernanda Retore , Rozalem Livia Del’Santo
Published: November 2023

Introdução: A função tireoidiana está intimamente associada às funções neuropsicológicas, incluindo o estado mental e as funções cognitivas. O hipotireoidismo subclínico (HSC) é definido como uma condição com níveis elevados de hormônio estimulador da tireoide (TSH) e níveis normais de tiroxina livre (T4). Objetivo: evidenciar a relação entre hipotireoidismo e transtorno depressivo. Metodologia: trata-se de uma pesquisa descritiva do tipo revisão integrativa. A pesquisa foi realizada através do acesso online nas bases de dados National Library of Medicine (PubMed MEDLINE), Scientific Electronic Library Online (Scielo), Cochrane Database of Systematic Reviews (CDSR), Google Scholar, EBSCO Information Services, no mês de agosto de 2021. Resultados: Ainda que não seja claro o papel desempenhado pelos hormônios tireoidianos na fisiopatologia dos transtornos mentais, tem sido sugerido que pequenas mudanças nos níveis de hormônio da tireoide, mesmo dentro da faixa normal, podem estar relacionadas à alteração da função cerebral na depressão. Atualmente, existem 2 hipóteses explicativas: o déficit de serotonina e o déficit de noradrenalina no sistema nervoso central provocados pelos distúrbios hormonais. É importante ressaltar que a via tireoidiana-psíquica é bidirecional, portanto, tanto alterações tireoidianas podem provocar sintomas depressivos ou exacerbar uma patologia psiquiátrica prévia, quanto a depressão pode promover distúrbios tireoidianos, sendo este segundo caso menos frequente.  Conclusão: O papel da função tireoidiana nas doenças depressivas é pouco claro. Embora existam algumas evidências de que discretas alterações tireoidianas predisponham a casos de depressão, as anormalidades específicas envolvendo a tireoide e os quadros depressivos permanecem pouco conhecidas. No entanto, existe um vínculo de causalidade.
A importância do Nutricionista para a promoção da saúde do indivíduo com resistência insulínica
Authors: Barretto Camilla Brand de Mattos , Santos Raphael Silva Lopes dos , Oliveira Narcisio Rios
Published: November 2023

A resistência à insulina acarreta na maior necessidade de insulina circulante para efetivação de suas funções e efeitos, requerendo do profissional de saúde atenção especial. Este trabalho buscou contribuir com reflexões acerca dos cuidados nutricionais e não farmacológicos para a resistência à insulina, enfatizando o papel do profissional nutricionista para a promoção da saúde do indivíduo com resistência insulínica. Trata-se de uma revisão de literatura, com buscas nas bases de dados da Biblioteca Virtual em Saúde e PubMed, utilizando materiais dos últimos 5 anos, com complementação de materiais oficiais do Ministério da Saúde, Conselho Federal de Nutricionistas e Associação Brasileira para o Estudo da Obesidade e da Síndrome Metabólica. Tendo sido observado o papel de hábitos de estilo de vida saudável, como tratamentos não farmacológicos eficazes para a resistência à insulina, com destaque a prática regular de atividade e exercício físico, redução do peso corporal, terapia comportamental, boa alimentação e nutrição. Cabendo ao profissional nutricionista papel de fundamental importância no incentivo, estabelecimento e fortalecimento desses hábitos. Por fim, destaca-se a necessidade e importância da implementação e fortalecimento de ações interdisciplinares voltadas a ações de atenção primária e promoção da saúde a fim de minimizar complicações relacionadas à resistência à insulina.
Classification of Credit Card Frauds Detection using machine learning techniques
Authors: Ismail Rasha Rokan , Khorsheed Farah Hatem
Published: November 2023

Credit card fraud refers to the illegal activities carried out by criminals. In this research paper, we delve into the topic by exploring four different approaches to analyze fraud, namely decision trees, logistic regression, support vector machines, and Random Forests. Our proposed technique encompasses four stages: inputting the dataset, balancing the data through sampling, training classifier models, and detecting fraud. To analyze the data, we utilized two methods: forward stepwise logistic regression analysis (LR) and decision tree analysis (DT), in addition to Random Forest and support vector machine. Based on the outcomes of our analysis, the decision tree algorithm produced the highest AUC and accuracy value, achieving a perfect score of 1. On the other hand, logistic regression yielded the lowest values of 0.33 and 0.2933 for AUC and accuracy, respectively. Moreover, the implementation of forest algorithms resulted in an impressive accuracy rate of 99.5%, which signifies a significant advancement in automating the detection of credit card fraud.
Perencanaan Pembangkit Listrik Tenaga Surya Skala Industri Berbasis PVsyst
Authors: Kartika Sari Resi Dwi Jayanti , Murdianto Ady
Published: November 2023

Pembangkit Listrik Tenaga Surya merupakan salah satu energi terbarukan yang sangat efisien dan efektif dalam upaya pemenuhan kebutuhan energi listrik yang terus meningkat. Hal tersebut sejalan dengan sasaran KEN sesuai peraturan pemerintah tentang tercapainya peran energi terbarukan sebesar 23% pada bauran Energi Primer di tahun 2025 dalam penyediaan dan pemanfaatan energy. Penelitian menggunakan Software Pvsyst dimungkinkan untuk melakukan perancangan system PLTS, menentukan komponen-komponennya serta memprediksi energi listrik yang dihasilkan oleh Sistem PLTS. Besarnya sistem PLTS dipengaruhi oleh lokasi geografis dan meteorologi serta I radiasi matahari. Pemilihan kapasitas panel surya yang tepat dapat mereduksi penggunaan lahan pembangunan PLTS. Hasil simulasi dan kajian PLTS diperoleh bahwa instalasi PLTS rooftop dengan kapasitas 4 MWp dibangun pada lahan sekitar 2 Ha dengan perencanaan komponen yang  terdiri dari modul PV 330 Wp, 30Vsebanyak 12.121 on-grid dengan inverter sebanyak 22 unit sebesar 150kW. Dari segi  energi listrik yang dihasilkan sebesar 902.7 kWh/ tahun.
Metode CNN Dan Metode Haar Cascade Untuk Mendeteksi Sepeda Motor Yang Melintasi Area Trotoar
Authors: Zaini Utsman Hadi , Rabi Abd
Published: November 2023

Penggunaan trotoar di indonesia masih belum optimal dikarenakan masih banyak yang menggunakan trotoar sebagai lahan parkir, tempat berjualan, dan pengendara sepeda motor yang nekat melewati trotoar pada saat terjadi kemacetan yang dapat membahayakan pejalan kaki. Adapun tujuan dari penelitian ini adalah untuk mendeteksi objek sepeda motor yang melewati trotoar dengan menggunakan pengolahan citra digital dengan metode CNN dan metode Haar Cascade sebagai perbandingannya untuk mendeteksi pelanggaran sepeda motor diarea trotar agar pengendara bermotor lebih tertib dan disiplin dalam berkendara. Pengolahan citra digital dapat digunakan untuk mendeteksi keberadaan sepeda motor pada trotoar yang dihasilkan oleh kamera yang kemudian akan diolah melalui beberapa proses segmentasi, deteksi, dan klasifikasi untuk mendapatkan hasilnya. Adapun hasil penelitian ini bahwa metode deteksi objek menggunakan CNN menghasilkan tingkat akurasi sebesar 88,4% dan metode Haar Cascade mendapatkan hasil akurasi 63,4% dari hasil pengujian menggunakan beberapa gambar untuk diuji.
Increasing the Effectiveness of Electricity-Generating Floors Through the Mechanical Energy of DC Generators
Authors: Rochman Sagita , Aini Rasyida Shabihah Zukro , Billah Mussafa
Published: November 2023

The increasing electricity consumption of the Indonesian population requires renewable energy as an alternative to electricity generation supplies. Renewable energy can be formed through mechanical energy in its simplest form, namely in the form of a footrest. Generally, energy-harvesting floors that utilise human footsteps are designed with piezoelectric sensors. This sensor is responsible for converting mechanical energy into electrical energy. However, the power generated from piezoelectrics is only around 0.041 μW to 240.59 μW. So, in this study, an alternative design for a footstep floor is proposed capable of harvesting electrical energy using a DC generator. The proposed platform consists of a platform design that utilises the translational motion of the gears on the gear rack and is assisted by four springs surrounding the sides of the iron plate. Apart from that, the platform has a power management and storage system. Unlike controllers in general, solar charger controllers are used for charging (voltage and current in the accumulator) and flowing current to the load (lights). The subjects used in this floor test ranged from 20-100 kg. Compared to floors that use piezoelectrics, the results are that floors with DC generators experience an increase in power of around 0.62%. Hence, DC generators are more effective in harvesting electrical energy.
Perancangan Papan Petunjuk Arah Menggunakan Mikrokontroler Dan Solar Panel Di Pondok Pesantren Nurul Jadid
Authors: Kiani Yoga , Sulistiyanto Sulistiyanto
Published: November 2023

Petunjuk arah dapat kita jumpai di tepi jalan yang berfungsi memberi petunjuk bagi pengguna jalan terhadap suatu lokasi atau tempat tertentu. Dengan melihat papan petunjuk arah kita dituntun atau  diberi pedoman kearah mana kita menuju sesuai dengan tempat yang hendak kita tuju. Biasanya petunjuk arah menunjukkan tempat atau lokasi tempat berupa nama lokasi, nama jalan kota, nama kantor, nama wisata, nama pertokoan, nama terminal, dan lain-lain yang biasanya di tempatkan di tempat yang mudah terlihat penggunajalan. Adanya petunjuk arah ini setiap pengguna jalan dituntun menuju kesuatu tempat sesuai tujuan dan sasaran perjalanan. Energi yang dihasilkan dari sinar matahari dapat dimanfaatkan untuk lampu display berberntuk penunjuk arah jalan dengan bantuan suatu alat yaitu, sel surya (solar panel). Sistem sel surya sangat memungkinkan untuk memanfaatkan energi sinar matahari pada saat waktu bersinarnya. Sistem PLTS yang dirangkai bekerja sesuai dengan yang dinginkan sebagai pemasok sumber tegangan adapun hasil pengujiannya dalam 3 hari yaitu: Di hari ke-1 tegangan yang dihasilkan dari tegangan 9,11v dc hingga 13,31v dc, hari ke-2 tegangan yang dihasilkan adalah dari tegangan 8,51v dc hingga 13,23v dc, dan hari ke-3 `8,43v dc hingga 13,26v dc. Sistem kontrol pada arduino digunakan sebagai pengatur on/off lampu dengan berpatokan kepada jam dan pengatur sensor ultrasonik sebagai sensor jarak untuk mengetahui jika ada sesorang yang melewati depan papan petunjuk arah sehingga membunyikan speaker yang sudah di atur suaranya.
Recent Advances in Diagnosing and Treating Helicobacter pylori through Botanical Extracts and Advanced Technologies
Authors: Addissouky Tamer A. , Ali Majeed M. A. , El Tantawy El Sayed Ibrahim , Wang Yuliang
Published: November 2023

Helicobacter pylori (H. pylori) infection is a major global health concern, with an estimated 50% of the world's population infected. The bacterium colonizes the stomach and is associated with a range of gastrointestinal diseases, including chronic gastritis, peptic ulcers, and gastric cancer. The current standard of care for H. pylori infection involves a combination of antibiotics and proton pump inhibitors (PPIs), but the widespread use of antibiotics has led to the development of antibiotic-resistant strains of H. pylori, making treatment more difficult. Recent advances in diagnostic strategies include the use of non-invasive tests and serological biomarkers. While the use of antibiotics and PPIs remains the primary treatment approach, there is a growing interest in alternative therapies, including botanical extracts, natural products, and traditional medicines. Recent research has also explored the potential of probiotics, phage therapy, and novel antibiotics, such as rifabutin and furazolidone, in the treatment of H. pylori infection. Recent studies have also explored the potential of artificial intelligence (AI) in the diagnosis and management of H. pylori infection. AI-assisted screening methods have identified novel botanical extracts and natural products with anti-H. pylori activity, providing new avenues for therapeutic development. Additionally, AI can improve diagnostic accuracy and treatment outcomes. Although these alternative approaches show promise, further research is needed to confirm their efficacy, safety, and optimal dosing. Novel therapies such as phage therapy and new antibiotics may provide an alternative to traditional treatments and help overcome antimicrobial resistance.
PELATIHAN GOOGLE CLASSROOM PADA GURU SEKOLAH DASAR DI DESA BALONGGEMEK JOMBANG
Authors: Dedy Rahman Prehanto  , Aries Dwi Indriyanti  , Mochamad Arif Irfaâ€™i
Published: November 2023

mastery of skills in the field of Information Technology. The purpose of implementing Community Service activities which took place in Balonggemek Village, Jombang Regency is to provide training and assistance for Google classroom training for elementary school teachers so that learning for elementary school students is more interesting and fun. The partners of this community service are elementary school teachers in Balonggemek Village, Jombang Regency. The methods used are identifying partner problems, preparation of activities (compilation of materials, necessary equipment), determining training capacity, schedule and arrangement of training events, implementation of activities and evaluation of activity implementation. The google classroom training materials consist of the functions and uses of google classroom, accessing google classroom, adding students to the class, viewing the class assignment page, viewing user pages, creating assignments, providing input and grades. The implementation of the community service activities went well and smoothly. This can be seen from the enthusiasm of the participants in the training. The evaluation results of the level understanding of the participants in the training can be seen by comparing the pre-test and post-test score, which shows 45% and 92%, respectively.Keywords: google classroom training, primary school teachers, Balonggemek Village, Jombang RegencyAbstrak: Pembelajaran di masa pandemi Covid-19 yang memprioritaskan pembelajaran secara daring atau online membutuhkan penguasaan kemampuan di bidang Teknologi Informasi. Tujuan pelaksanaan kegiatan Pengabdian Kepada Masyarakat (PKM) yang mengambil lokasi di Desa Balonggemek Kabupaten Jombang adalah memberi pelatihan dan pendampingan pelatihan google classroom bagi guru-guru Sekolah Dasar agar pembelajaran kepada murid-murid Sekolah Dasar lebih menarik dan menyenangkan. Mitra kegiatan PKM adalah guru-guru Sekolah Dasar di Desa Balonggemek Kabupaten Jombang. Metode yang dilakukan adalah mengidentifikasi permasalahan mitra, persiapan kegiatan (penyusunan materi, perlengkapan yang diperlukan), menentukan kapasitas pelatihan, jadwal dan susunan acara pelatihan, pelaksanaan kegiatan serta evaluasi pelaksanaan kegiatan. Materi pelatihan google classroom terdiri dari fungsi dan kegunaan google classroom, mengakses google classroom, menambahkan siswa ke kelas, melihat halaman tugas kelas, melihat halaman pengguna, membuat tugas, memberikan masukan dan nilai. Kegiatan pelaksanaan Pengabdian Kepada Masyarakat (PKM) berlangsung baik dan lancar. Hal ini terlihat dari antusias para peserta dalam mengikuti pelatihan. Hasil evaluasi terhadap tingkat pemahaman peserta dalam mengikuti pelatihan terlihat dari hasil sebelum pelatihan (pre test) sebesar 45% dan sesudah pelatihan (post test) yang menunjukkan hasil 92%.Kata kunci: Pelatihan google classroom, guru Sekolah Dasar, Desa Balonggemek Kabupaten Jombang
ALUR PENDAFTARAN, PENETAPAN DAN PEMBAYARAN PBB WAJIB PAJAK BARU DI BAPENDA JOMBANG
Authors: Moh. Fathulloh  , Siti Ulfah Rochmawati  , Rachma Agustina
Published: November 2023

Abstract: One of the sources of tax funds comes from the Land and Building Tax. Land and Building Duty (PBB) is the middle recorded in the State Income and Consumption Spending plan (APBN). The motivation behind this examination is: "To discover the Method for Enrollment, Assurance, and Installment of Land and Building Duty for New Citizens at BAPENDA Jombang'. The examination strategy utilized in this exploration is spellbinding subjective exploration. Concerning how to direct research, in particular by perceptions made by the creator and meetings with workers in regards to the investigation of the degree of consistence of individual citizens at the Workplace of the Jombang Regime Income Organization. The aftereffects of this exploration in the current time, there are as yet many lay circles who don't comprehend and think that it is troublesome with regards to the strategies and components of this PBB-P2 transformation.Keywords: registration, determination, paymentAbstrak: Salah satu sumber dana pajak berasal dari Pajak Bumi dan Bangunan. Pajak Bumi dan Bangunan (PBB) merupakan yang tengah tercatat dalam Rencana Anggaran Pendapatan dan Belanja Negara (APBN). Motivasi yang melatarbelakangi penelitian ini adalah: â€œUntuk mengetahui Tata Cara Pendaftaran, Penjaminan, dan Angsuran Pajak Bumi dan Bangunan Bagi Warga Negara Baru di BAPENDA Jombangâ€. Strategi pengujian yang digunakan dalam eksplorasi ini adalah eksplorasi subyektif memukau. Tentang bagaimana mengarahkan penelitian, khususnya persepsi yang dibuat oleh pencipta dan pertemuan dengan pekerja mengenai penyelidikan tingkat konsistensi individu warga di Tempat Kerja Organisasi Pendapatan Rezim Jombang. Efek dari eksplorasi ini saat ini, masih banyak kalangan awam yang kurang paham dan menganggap merepotkan terkait strategi dan komponen transformasi PBB-P2 ini.Kata kunci: pendaftaran, penetapan, pembayaran
SEKOLAH RAKYAT DI DUSUN RAPAH OMBO MELALUI KEGIATAN SUPER CAMP
Authors: M. Bambang Edi Siswanto  , Ratih Asmarani  , Muhammad Nuruddin
Published: November 2023

Abstract: This research was carried out on the basis of the awareness of the devotees who were moved by their enthusiasm for the people of the Rapah Ombo hamlet. This activity is a unique activity that has never existed in the village so that residents and children are very enthusiastic about participating in this activity. This activity was carried out in the hamlet of Rapah Ombo which is a partner in this service activity, which is one of the hamlets left behind in Jombang Regency because of the difficulty of road access to Dusun Rapah Ombo. This activity is carried out through the Community Learning method or learning community known as the People's School with a Super Camp approach which is a more familiar designation in the ears of the Rapah Ombo community. The results of this study are community service which has been carried out by 60 participants who were divided into 12 groups, each group of 5 people, each group prepared 1 tent, the participants took part in this activity until the end which was closed in the morning with outbound activities and distribution. gifts as an appreciation for their enthusiasm for participating in this activity. This activity is important to continue because it has made the people of the rapah ombo hamlet go viral because it has changed the civilization that initially studied only indoors, now becomes more enthusiastic because they can learn while playing with a tent as a place for them to take shelter.Keywords: People's School, Super Camp, Rapah OmboAbstrak: Pengabdian ini dilaksanakan atas dasar kesadaran dari pengabdi sebagai pemerhati keilmuan yang tergugah semangatnya kepada masyarakat dusun Rapah Ombo kegiatan ini merupakan kegiatan unik yang belum pernah ada di desa tersebut sehingga warga dan anak -anak sangat antusias mengikuti kegiatan ini. Kegiatan ini di laksanakan di dusun rapah ombo yang merupakan mitra dalam kegiatan pengabdian ini, merupakan salah satu dusun yang tertinggal di Kabupaten Jombang sulitnya akses jalan menuju Dusun Rapah Ombo. Kegiatan ini di lakukan melalui metode learning Community atau masyarakat belajar yag di kenal dengan sebutan Sekolah Rakyat dengan pendekatan Super camp yang merupakan sebutan yang lebih femilier di telinga ,masyarakat rapah ombo. Adapun hasil dari Pengabdian ini adalah Pengabdian masyarakat yang telah di lakukan 60 peserta yang di bagi menjadi 12 kelompok setiap kelompok ada 5 orang yang setiap kelompok di siapkan 1 tenda, para peserta mengikuti kegiatan ini hingga selesai yang pagi nya di tutup dengan kegiatan outbond dan pembagian hadiah sebagai apresiasi atas semangat mereka mengikuti kegiatan ini. Kegiatan ini penting untuk terus diadakan karena menjadikan masyarakat dusun rapah ombo menjadi viral karena mengubah peradaban yang awalnya belajar hanya dalam ruangan sekarang menjadi lebih semangat karena bisa belajar sambil bermain dengan tenda sebagai tempat mereka berteduh.Kata kunci: Sekolah Rakyat, Super Camp, Rapah Ombo
PENGEMBANGAN PUSAT KEGIATAN WARGA ASEM PAYUNG KEL. GEBANG PUTIH SURABAYA
Authors: Josephine Roosandriantini  , Lucia Ina Trisjanti  , Y.A. Widriyakara Setiadi  , Anas Hidayat  , Stefanus Prabani Setio  , Heristama Anugerah Putra
Published: November 2023

The Gebang Putih area is a fairly densely populated settlement because each residence does not have an open yard. The activities of the youth or local residents are limited to gathering at locations outside the RW 003 environment. The results of observations and interviews with community leaders in RT. 02, it was found that residents of RW 003 needed a place for sports activities, gatherings, and discussions for residents of RW 003. The purpose of this community service was so that residents had a new activity center that was able to accommodate gathering, exercise, and socializing activities. This community service is expected to enable residents to carry out activities in a sustainable manner around their homes, thereby creating a friendly atmosphere and increasing a sense of brotherhood and harmony among residents. Community service activities carried out were utilizing the sewer side as a place for sports activities, and discussions for residents of RW 003. The method used was an observation, and interviews with the chairman of RW 003 and also residents of 003 Asem Umbrella. As a result of this community service, Asem Payung RW 003 village has infrastructure for joint activities between residents, such as ping pong, table tennis, or a gathering area.
Redesign Model Instalasi Pipa Saluran Air Bersih Di Desa Toniku Jailolo Selatan
Authors: Herbelubun Muhammad Muzni , Hartono Rudi , Hardi Witono
Published: November 2023

The purpose of the service program to redesign the installation of clean water pipelines is to provide new installations and repair clean water distribution pumps that are able to distribute clean water originating from river water in the Toniku Village area so that the water distribution system runs more evenly, both to the reservoir and to the reservoir. the community directly. The implementation of the activity begins with an initial survey to see the condition of the artificial wells and water reservoirs that will be repaired where there are artificial wells installed on the banks of the river. Repairs to the pipe installation are carried out by replacing 2 4-inch pipes so that the flow of water that will enter the reservoir does not suffer losses or is wasted. The initial design before the change was that there were many pipe connections that were installed from the pump to the reservoir so that the water flowing into the reservoir experienced a lot of loss or wasted a lot. From the results of the field review, the electrical capacity to drive the pump is not sufficient because the type of electrical cable connected is not suitable or unable to drive the two pumps. Errors also occur in the installation of capacitors where the pump has a 40 F capacitor type but the one installed is 50 F. For the problem of electricity capacity, the village government has tried to coordinate with PLN to replace the power cable. As for the capacitor problem, in this program we bought 2 capacitors to be replaced and installed. Keywords: Redesign, Water Pump, Reservoir, Drain Installation
Perbaikan Instalasi Pipa Saluran Distribusi Air dan MCK Di Desa Takofi
Authors: Hi Abbas Said , Umron Amat , Bahri LM Syamsul , Rais Sandi
Published: November 2023

Takofi Village is one of the sub-districts in Moti District. It has an area of 111.39 Km² and is divided into 6 RTs. Because this village is located on the coast, access to clean water and toilet facilities is minimal and unsupportive in terms of health. PKM 2022 activities carried out by the mechanical engineering study program at the Khairun University Faculty of Engineering, one of which is the repair of water distribution pipe installations and toilets, where the current condition of MCK in Takofi village is still inadequate. As for the implementation of repairs to the structure of water distribution channel pipes and toilets, repairs to the installation of water distribution channel pipes and toilets are carried out as well as advice on how to utilize clean water supply and be able to provide a place for waste disposal from toilets so as not to pollute the water, air, and soil in the Takofi village neighborhood. The results of the identification of problems in the implementation of this activity include; a lack of knowledge about the behavior of using MCK, Lack of knowledge about the use of clean water, damage to MCK distribution channel pipes, and improper arrangement of pipe installations, resulting in the malfunction of the water distribution network in MCK..Keywors; Pipeline Installation, Clean Water, MCK, Takofi Village
Baicalin-modified polyethylenimine for miR-34a efficient and safe delivery
Authors: Wang Yingying , Wang Baiyan , Xiao Yangfan , Cai Qingchun , Xing Junyue , Tang Hao , Li Ruiqin , Zhang Hongtao
Published: November 2023

The security and efficiency of gene delivery vectors are inseparable for the successful construction of a gene delivery vector. This work provides a practical method to construct a charge-regulated, hydrophobic-modified, and functionally modified polyethylenimine (PEI) with effective gene delivery and perfect transfection performance through a condensation reaction, named BA-PEI. The carrier was shown to possess a favorable compaction of miRNAs into positively charged nanoparticles with a hydrodynamic size of approximately 100 nm. Additionally, BA-PEI possesses perfect degradability, which benefits the release of miR-34a from the complexes. In A549 cells, the expression level of the miR-34a gene was checked by Western blotting, which reflects the transfection efficiency of BA-PEI/miR-34a. When miR-34a is delivered to the cell, the perfect anti-tumor ability of the BA-PEI/miR-34a complex was systematically evaluated with the suppressor tumor gene miR-34a system in vitro and in vivo. BA-PEI-mediated miR-34a gene transfection is more secure and effective than the commercial transfection reagent, thus providing a novel approach for miR-34a-based gene therapy.
Profound and selective lymphopaenia in primary lymphatic anomaly patients demonstrates the significance of lymphatic-lymphocyte interactions
Authors: Pearce Julian , Hadcocks Linda , Mansour Sahar , van Zanten Malou , Jeffery Steve , Gordon Kristiana , Ostergaard Pia , Mortimer Peter , Macallan Derek C.
Published: November 2023

Introduction

The lymphatic system has a pivotal role in immune homeostasis. To better understand this, we investigated the impact of Primary Lymphatic Anomalies (PLA) on lymphocyte numbers and phenotype.

Methods

The study comprised (i) a retrospective cohort: 177 PLA subjects from the National Primary Lymphatic Anomaly Register with clinical and laboratory data, and (ii) a prospective cohort: 28 patients with PLA and 20 healthy controls. Patients were subdivided using established phenotypic diagnostic categories and grouped into simplex (localised tissue involvement only) and systemic (involvement of central lymphatics). Further grouping variables included genital involvement and the likelihood of co-existent intestinal lymphangiectasia. Haematology laboratory parameters were analysed in both cohorts. In the prospective cohort, prospective blood samples were analysed by flow cytometry for markers of proliferation, differentiation, activation, skin-homing, and for regulatory (CD4+Foxp3+) T cells (Treg).

Results

In patients with PLA, lymphopaenia was frequent (22% of subjects), affected primarily the CD4+ T cell subset, and was more severe in subjects with systemic versus simplex patterns of disease (36% vs 9% for lymphopaenia; 70% vs 33% for CD4+ cells). B cells, NK cells and monocytes were better conserved (except in GATA2 deficiency characterised by monocytopaenia). Genital oedema and likelihood of concomitant intestinal lymphangiectasia independently predicted CD4+ T cell depletion. Analysing CD4+ and CD8+ T cells by differentiation markers revealed disproportionate depletion of naïve cells, with a skewing towards a more differentiated effector profile. Systemic PLA conditions were associated with: increased expression of Ki67, indicative of recent cell division, in naïve CD4+, but not CD8+ T cells; increased levels of activation in CD4+, but not CD8+ T cells; and an increased proportion of Treg. Skin-homing marker (CCR10, CLA and CCR4) expression was reduced in some patients with simplex phenotypes.

Discussion

Patients with PLA who have dysfunctional lymphatics have a selective reduction in circulating lymphocytes which preferentially depletes naïve CD4+ T cells. The presence of systemic disease, genital oedema, and intestinal lymphangiectasia independently predict CD4 lymphopaenia. The association of this depletion with immune activation and increased circulating Tregs suggests lymphatic-lymphocyte interactions and local inflammatory changes are pivotal in driving immunopathology.
A global examination of ecological niche modeling to predict emerging infectious diseases: a systematic review
Authors: Lawrence Ted J. , Takenaka Bryce P. , Garg Aastha , Tao Donghua , Deem Sharon L. , Fèvre Eric M. , Gluecks Ilona , Sagan Vasit , Shacham Enbal
Published: November 2023

Introduction

As emerging infectious diseases (EIDs) increase, examining the underlying social and environmental conditions that drive EIDs is urgently needed. Ecological niche modeling (ENM) is increasingly employed to predict disease emergence based on the spatial distribution of biotic conditions and interactions, abiotic conditions, and the mobility or dispersal of vector-host species, as well as social factors that modify the host species’ spatial distribution. Still, ENM applied to EIDs is relatively new with varying algorithms and data types. We conducted a systematic review (PROSPERO: CRD42021251968) with the research question: What is the state of the science and practice of estimating ecological niches via ENM to predict the emergence and spread of vector-borne and/or zoonotic diseases?

Methods

We searched five research databases and eight widely recognized One Health journals between 1995 and 2020. We screened 383 articles at the abstract level (included if study involved vector-borne or zoonotic disease and applied ENM) and 237 articles at the full-text level (included if study described ENM features and modeling processes). Our objectives were to: (1) describe the growth and distribution of studies across the types of infectious diseases, scientific fields, and geographic regions; (2) evaluate the likely effectiveness of the studies to represent ecological niches based on the biotic, abiotic, and mobility framework; (3) explain some potential pitfalls of ENM algorithms and techniques; and (4) provide specific recommendation for future studies on the analysis of ecological niches to predict EIDs.

Results

We show that 99% of studies included mobility factors, 90% modeled abiotic factors with more than half in tropical climate zones, 54% modeled biotic conditions and interactions. Of the 121 studies, 7% include only biotic and mobility factors, 45% include only abiotic and mobility factors, and 45% fully integrated the biotic, abiotic, and mobility data. Only 13% of studies included modifying social factors such as land use. A majority of studies (77%) used well-recognized ENM algorithms (MaxEnt and GARP) and model selection procedures. Most studies (90%) reported model validation procedures, but only 7% reported uncertainty analysis.

Discussion

Our findings bolster ENM to predict EIDs that can help inform the prevention of outbreaks and future epidemics.

Systematic review registration

https://www.crd.york.ac.uk/prospero/, identifier (CRD42021251968).
Effects of Age on Compounds, Metabolites and Meat Quality in Beijing-You Chicken Breast Meat
Authors: Chen Xia , Cao Jing , Chang Cheng , Geng Ailian , Wang Haihong , Chu Qin , Yan Zhixun , Zhang Xiaoyue , Zhang Yao , Liu Huagui , Zhang Jian
Published: November 2023

The physical properties, free amino acids, and metabolites of Beijing-You chicken (BYC) breast meat aged 90, 120, and 150 days were analyzed to investigate the flavor changes with age. The shear force and intramuscular fat increased from 90 to 120 days significantly. The contents of total free amino acids and essential amino acids decreased from 90 to 120 days significantly. No significant differences were detected between 120 and 150 days. The contents of sweet amino acids, bitter amino acids, and umami amino acids showed no significant differences between different ages. In addition, GC-MS and LC-MS were integrated for metabolite detection in breast meat. A total of 128, 142, and 88 differential metabolites were identified in the comparison groups of 120 d vs. 90 d, 150 d vs. 90 d, and 150 d vs. 120 d. Amino acids and lipids were the main differential metabolites. The pathway analysis showed that arginine biosynthesis, histidine metabolism, purine metabolism, and cysteine and methionine metabolism were the main pathways involved in flavor formation during BYC development. It was also found that the metabolites associated with flavor, such as methionine, cysteine, glucose, anserine, arachidonic acid, and glycerol 1-phosphate, were significantly affected by age.
Low Plasma Levels of Soluble Endoglin and Cardiovascular Events in Patients Undergoing Coronary Angiography
Authors: Saita Emi , Kishimoto Yoshimi , Aoyama Masayuki , Ohmori Reiko , Kondo Kazuo , Momiyama Yukihiko
Published: November 2023

TGF-β is recognized as playing a protective role against atherosclerosis. Endoglin is a receptor for TGF-β, and its expression is upregulated in atherosclerotic plaques. Endoglin is secreted from the cell membrane into the circulation as a soluble form (sEng). We previously reported that plasma sEng levels were low in patients with coronary artery disease (CAD). However, the prognostic value of sEng levels has not been clarified. We investigated the association between plasma sEng levels and cardiovascular events in 403 patients who had an elective coronary angiography and were then followed up. Cardiovascular events were defined as cardiovascular death, myocardial infarction, unstable angina, heart failure, stroke, or coronary revascularization. Of the 403 patients, 209 (52%) had CAD. Plasma sEng levels were lower in patients with CAD than in those without CAD (median 4.26 vs. 4.41 ng/mL, p < 0.025). During a mean follow-up period of 7.5 ± 4.5 years, cardiovascular events occurred in 79 patients. Compared with 324 patients without events, 79 with events had lower sEng levels (3.95 vs. 4.39 ng/mL) and more often had an sEng level < 3.9 ng/mL (47% vs. 28%) (p < 0.02). A Kaplan–Meier analysis showed lower event-free survival in patients with sEng < 3.9 ng/mL than in those with ≥3.9 ng/mL (p < 0.02). In a multivariate Cox proportional hazards analysis, the sEng level (<3.9 ng/mL) was an independent predictor of cardiovascular events (hazard ratio: 1.59; 95%CI: 1.01–2.49). Furthermore, only among the 209 patients with CAD, the sEng level was also a predictor of further cardiovascular events (hazard ratio: 2.07; 95%CI: 1.24–3.45). Thus, low plasma sEng levels were found to be associated with an increased risk of cardiovascular events in patients with CAD and patients undergoing coronary angiography.
Two-Stage Surgical Management for Acutely Presented Large Vestibular Schwannomas: Report of Two Cases
Authors: Keles Abdullah , Ozaydin Burak , Erginoglu Ufuk , Baskaya Mustafa K.
Published: November 2023

The surgical management of vestibular schwannomas should be based on their presentation, neuro-imaging findings, surgeons’ expertise, and logistics. Multi-stage surgery can be beneficial for large-sized lesions with acute presentations. Herein, we highlighted the indications for two cases managed initially through the retrosigmoid and, subsequently, translabyrinthine approaches. The first case presented with acute balance and gait issues and a long history of hearing loss and blurred vision. Neuroimaging findings revealed a cerebellopontine angle lesion, resembling a vestibular schwannoma, with significant brainstem compression and hydrocephalus. Due to the rapidly deteriorating clinical status and large-sized tumor, we first proceeded with urgent decompression via a retrosigmoid approach, followed by gross total resection via a translabyrinthine approach two weeks later. The second case presented with gradually worsening dizziness and hemifacial numbness accompanied by acute onset severe headaches and hearing loss. Neuroimaging findings showed a large cerebellopontine angle lesion suggestive of a vestibular schwannoma with acute intratumoral hemorrhage. Given the acute clinical deterioration and large size of the tumor, we performed urgent decompression with a retrosigmoid approach followed by gross total resection through a translabyrinthine approach a week later. Post-surgery, both patients showed excellent recovery. When managing acutely presented large-sized vestibular schwannomas, immediate surgical decompression is vital to avoid permanent neurological deficits.