bluuebunny/crossref_metadata_2025 huggingface dataset:
Improving Outcomes Through Personalized Recommendations in a Remote Diabetes Monitoring Program: Observational Study (Preprint)
Authors: Kamath Sowmya , Kappaganthu Karthik , Painter Stefanie , Madan Anmol
Published: March 2022

BACKGROUND

Diabetes management is complex, and program personalization has been identified to enhance engagement and clinical outcomes in diabetes management programs. However, 50% of individuals living with diabetes are unable to achieve glycemic control, presenting a gap in the delivery of self-management education and behavior change. Machine learning and recommender systems, which have been used within the health care setting, could be a feasible application for diabetes management programs to provide a personalized user experience and improve user engagement and outcomes.

OBJECTIVE

This study aims to evaluate machine learning models using member-level engagements to predict improvement in estimated A1c and develop personalized action recommendations within a remote diabetes monitoring program to improve clinical outcomes.

METHODS

A retrospective study of Livongo for Diabetes member engagement data was analyzed within five action categories (interacting with a coach, reading education content, self-monitoring blood glucose level, tracking physical activity, and monitoring nutrition) to build a member-level model to predict if a specific type and level of engagement could lead to improved estimated A1c for members with type 2 diabetes. Engagement and improvement in estimated A1c can be correlated; therefore, the doubly robust learning method was used to model the heterogeneous treatment effect of action engagement on improvements in estimated A1c.

RESULTS

The treatment effect was successfully computed within the five action categories on estimated A1c reduction for each member. Results show interaction with coaches and self-monitoring blood glucose levels were the actions that resulted in the highest average decrease in estimated A1c (1.7% and 1.4%, respectively) and were the most recommended actions for 54% of the population. However, these were found to not be the optimal interventions for all members; 46% of members were predicted to have better outcomes with one of the other three interventions. Members who engaged with their recommended actions had on average a 0.8% larger reduction in estimated A1c than those who did not engage in recommended actions within the first 3 months of the program.

CONCLUSIONS

Personalized action recommendations using heterogeneous treatment effects to compute the impact of member actions can reduce estimated A1c and be a valuable tool for diabetes management programs in encouraging members toward actions to improve clinical outcomes.
Locating Youth Exposed to Parental Justice Involvement in the Electronic Health Record: Development of a Natural Language Processing Model (Preprint)
Authors: Boch Samantha , Hussain Syed-Amad , Bambach Sven , DeShetler Cameron , Chisolm Deena , Linwood Simon
Published: March 2022

BACKGROUND

Parental justice involvement (eg, prison, jail, parole, or probation) is an unfortunately common and disruptive household adversity for many US youths, disproportionately affecting families of color and rural families. Data on this adversity has not been captured routinely in pediatric health care settings, and if it is, it is not discrete nor able to be readily analyzed for purposes of research.

OBJECTIVE

In this study, we outline our process training a state-of-the-art natural language processing model using unstructured clinician notes of one large pediatric health system to identify patients who have experienced a justice-involved parent.

METHODS

Using the electronic health record database of a large Midwestern pediatric hospital-based institution from 2011-2019, we located clinician notes (of any type and written by any type of provider) that were likely to contain such evidence of family justice involvement via a justice-keyword search (eg, prison and jail). To train and validate the model, we used a labeled data set of 7500 clinician notes identifying whether the patient was ever exposed to parental justice involvement. We calculated the precision and recall of the model and compared those rates to the keyword search.

RESULTS

The development of the machine learning model increased the precision (positive predictive value) of locating children affected by parental justice involvement in the electronic health record from 61% (a simple keyword search) to 92%.

CONCLUSIONS

The use of machine learning may be a feasible approach to addressing the gaps in our understanding of the health and health services of underrepresented youth who encounter childhood adversities not routinely captured—particularly for children of justice-involved parents.
Emotion-Based Reinforcement Attention Network for Depression Detection on Social Media: Algorithm Development and Validation (Preprint)
Authors: Cui Bin , Wang Jian , Lin Hongfei , Zhang Yijia , Yang Liang , Xu Bo
Published: March 2022

BACKGROUND

Depression detection has recently received attention in the field of natural language processing. The task aims to detect depressed users based on their historical posts on social media. Existing works are mainly divided into using all historical posts, and selecting depression indicator posts. However, these methods fail to effectively extract deep emotional semantic features or simply concatenate emotional representation. To solve this problem, we propose a model to extract deep emotional semantic features and select indicator posts based on the emotional states.

OBJECTIVE

We developed an emotion-based reinforcement attention network for depression detection of users on social media.

METHODS

The proposed model is composed of two components: the emotion extraction network used to capture deep emotional semantic information, and the RL attention network used to select depression indicator posts based on the emotional states. Finally, we concatenate the output of these two parts and send them to the classification layer for depression detection.

RESULTS

Experimental results of our model on the MDDL dataset outperforms the state-of-the-art baselines. Specifically, the proposed model achieves accuracy, precision, recall, and F1-score by 90.6%, 91.2%, 89.7%, and 90.4%, respectively.

CONCLUSIONS

The proposed model utilizes historical posts of users for depression detection that can effectively identify users’ depression tendencies. The experimental results show that the emotion extraction network and the RL selection layer based on emotional states can effectively improve the accuracy of detection. In addition, sentence-level attention layer can capture core posts.
Identification of Intracranial Lesions Using Machine Learning. A Decision Support System Prototype for Critical Situations in Neuro-Oncology Clinics (Preprint)
Authors: Akakın Akın , Sümerkent Kadir , Demirci Otluoglu Gulden , Zorlu Emre , Demir Mustafa Kemal , Kılıç Turker
Published: March 2022

BACKGROUND

Detection and classification of intracranial lesions using MRI is a difficult procedure because of the variety and complexity of the lesions. Despite MRI application and interpretation is a time-consuming procedure, it is the most preferred modality in neuro-oncology cases and is the most commonly used neuro-imaging technique in clinics.

OBJECTIVE

Efficient classification of the MRI scans is another problem in most neuro-oncology clinics due to several reasons but primarily heavy workload especially in critical situations. Unfortunately, misdiagnosis, delayed diagnosis and intervention are frequently encountered problems due to these reasons. This article proposes a technique we have developed to distinguish human cranial MRI images with and without brain tumors using artificial neural networks.

METHODS

Material and Methods: In the first stage of the proposed technique, the basic features of each image are defined by discrete wavelet transformation (DWT) technique by sequentially analyzing MRI scans falling into a central storage area. Then, the features of MRI images are grouped using principal component analysis (PCA) technique, and the number of features to be considered in the analysis is minimized. During the classification, two classifiers based on feed-forward artificial neural network (FF-ANN) and back-propagation neural network are used to mark each image as "normal" or `abnormal".

RESULTS

Results: Magnetic resonance images of 1.900 cases analyzed with the algorithm. Of these 1,641 patients with radiology-confirmed brain tumors were operated and 359 patients included in the test dataset used for validation purposes. Radiology department confirmed that there were no brain tumors in the validation group.

CONCLUSIONS

Conclusion: With the proposed method, our goal is to reduce the misdiagnosis rate while prioritizing scans involving cranial lesions by analyzing the scans that are waiting for evaluation in the MRI pool for the first stage. In the upcoming stages of our study, we aim to add a second level of classification for the classified MRI scans that will prioritize the cases like aneurysms which also require urgent attention.

CLINICALTRIAL

N/A
Multifaceted Intervention to Increase the Use of Home Dialysis
Authors: Manns Braden J. , Garg Amit X. , Sood Manish M. , Ferguson Thomas , Kim S. Joseph , Naimark David , Nesrallah Gihad E. , Soroka Steven D. , Beaulieu Monica , Dixon Stephanie N. , Alam Ahsan , Allu Selina , Tangri Navdeep
Published: March 2022

Background and objectives

Home dialysis therapies (peritoneal and home hemodialysis) are less expensive and provide similar outcomes to in-center hemodialysis, but they are underutilized in most health systems. Given this, we designed a multifaceted intervention to increase the use of home dialysis. In this study, our objective was to evaluate the effect of this intervention on home dialysis use in CKD clinics across Canada.

Design, setting, participants, & measurements

We conducted a cluster randomized controlled trial in 55 CKD clinic clusters in nine provinces in Canada between October 2014 and November 2015. Participants included all adult patients who initiated dialysis in the year following the intervention. We evaluated the implementation of a four-component intervention, which included phone surveys from a knowledge translation broker, a 1-year center-specific audit/feedback on home dialysis use, delivery of an educational package (including tools aimed at both providers and patients), and an academic detailing visit. The primary outcome was the proportion of patients using home dialysis at 180 days after dialysis initiation.

Results

A total of 55 clinics were randomized (27 in the intervention and 28 in the control), with 5312 patients initiating dialysis in the 1-year follow-up period. In the primary analysis, there was no difference in the use of home dialysis at 180 days in the intervention and control clusters (absolute risk difference, 4%; 95% confidence interval, −2% to 10%). Using a difference-in-difference comparison, the use of home dialysis at 180 days was similar before and after implementation of the intervention (difference of 0% in intervention clinics; 95% confidence interval, −2% to 3%; difference of 0.8% in control clinics; 95% confidence interval, −1% to 3%; P=0.84).

Conclusions

A multifaceted intervention did not increase the use of home dialysis in adults initiating dialysis.

Clinical Trial registry name and registration number:

A Cluster Randomized Trial to Assess the Impact of Patient and Provider Education on Use of Home Dialysis, NCT02202018
Glossophobia: Fear of Public Speaking Among Senior High School Students of Aliaga National High School
Authors: T. Tamayo Vladimir , T. Caber Jonalyn
Published: March 2022

Globalization had attracted millions of students around the world and there is a huge flux of students who are travelling abroad for educational purposes. The aim of these students is to gain education and achieve their dreams. But travelling abroad for education and living in a foreign country is not an easy process. During this educational journey and transition from their home country to host country international students face huge challenges of adaptation and the challenges can be in terms of Academics, socio-cultural, personal, etc. So in order to acheieve the main goal of education, International students must adapt to the new envirnoment of the host country. The study aimed to develop validity and reliability of the International adjustment scale in Turkey. A pool of 100 statements was reduced to 35 after validation resulting in five distinct domains of adjustment, such as Academic adjustment (11), Social adjustment (9), Personal adjustment (6), General Living adjustment (4) and Institutional adjustment (3). The multidimensional adjustment was developed and validated for International students in Turkey.
VOJNA NEUTRALNOST REPUBLIKE SRBIJE KAO STRATEGIJSKA KATEGORIJA
Authors: Vračar Milinko , Ćurčić Milica
Published: March 2022

Strategija kao svojevrsna ideja ili zamisao kako ostvariti nacionalne interese ima važnu ulogu u egzistenciji države. Njen uspeh počiva na osmišljavanju i implementaciji racionalnih idejnih rešenja, tačnije, onih rešenja koja su realno ostvariva u praksi a, pri tome, efektna i isplativa. Zato je važno razumeti da strateško mišljenje, iako pretežno umna i kreativna delatnost, ima i svoju razumsku i kritičku zasnovanost. Ona se prepoznaje u „strategijskoj logici“ kao svojevrsnom logičko-metodološkom postupku dolaženja do racionalnih rešenja. Međutim, ignorisanje te logike ili, pak, njeno nerazumevanje i pogrešna primena u procesu formulisanja strategije, ima za posledicu iznalaženje neracionalnih rešenja što dovodi do pojave spontanosti i neizvesnosti u egzistenciji države. Male zemlje, poput Srbije, nemaju privilegiju spontanog ponašanja u međunarodnoj politici poput velikih sila jer posledice takvog ponašanja obično plaćaju visokom cenom. Upravo zbog toga one moraju krajnje pažljivo da pristupe formulisanju strategija kojima se kreira njihova politika nacionalne bezbednosti. Između ostalog, to podrazumeva pravilno razumevanje i jasno definisanje strategijskih kategorija, poput nacionalnih interesa, ciljeva, sredstava i koncepata, a zatim i razumevanje njihovih odnosa u procesu strateškog mišljenja čije su faze odvijanja definisane strategijskom logikom. Polazeći od činjenice da u Srbiji postoji izvesni deficit teorijskih znanja u formulisanju strateških dokumenata, postavlja se pitanje pravilnosti određenja vojne neutralnosti u Strategiji odbrane Republike Srbije. Oslanjajući se na postojeće teorijske okvire strateških studija, istraživačka pažnja u radu usmerena je ka dokazivanju teze da ovo spoljnopolitičko opredeljenje Srbije ne predstavlja njen odbrambeni interes, kako je definisano u navedenoj strategiji, već sredstvo kojim se takvi njeni interesi ostvaruju.
ZNAČENJA VOJNE NEUTRALNOSTI SRBIJE
Authors: Jovanović Miloš
Published: March 2022

Vojna neutralnost Srbije, proklamovana u Rezoluciji Narodne skupštine o zaštiti suvereniteta, teritorijalnog integriteta i ustavnog poretka Republike Srbije od 26. decembra 2007. godine, neretko je pogrešno shvatana, tendenciozno tumačena i neosnovano kritikovana. U radu se preciznije određuju smisao i domašaj vojne neutralnosti kroz tačno definisanje različitih kategorija koje se vezuju za pojam vojne neutralnosti odnosno neutralnosti. Nadalje se u radu ispituje primerenost pozicije vojne neutralnosti Srbije odnosno postojanje dubljeg kulturološko-istorijskog utemeljenja s jedne strane, kao i primerenost predmetnog spoljnopolitičkog i bezbednosnog opredeljenja u datom međunarodnom kontekstu i geopolitičkom okruženju s druge strane.
STRATEŠKO PROMIŠLJANJE VOJNE NEUTRALNOSTI SRBIJE: MOGUĆNOSTI, IZAZOVI I RIZICI
Authors: Blagojević Veljko
Published: March 2022

Koncept neutralnosti je u istorijskom padu, najviše zbog procesa globalizacije, ali i negativnih iskustava neutralnih država u svetskim ratovima. Tri države u Evropi su se odlučile za neutralnu politiku u posthladnoratovskom periodu, među kojima je i Srbija. Problemi sa kojima se suočava srpski narod posledica su „razbi-raspada“ bivše Jugoslavije i negativnog međunarodnog imidža koji je formiran u javnom mnjenju na Zapadu tokom devedesetih. Srbija se opredelila za dugoročnu primenu koncepta vojne neutralnosti, nakon višegodišnjeg nastojanja da formira adekvatan strategijski okvir koji bi trebalo da obezbedi optimalne mogućnosti za realizaciju nacionalnih interesa u realnom geopolitičkom i geostrateškom okruženju. Hipotetički okvir rada se zasniva na stanovištu da opredeljenje za vojnu neutralnost nudi mnoge strateške prednosti za realizaciju nacionalnih interesa, ali se u previziji strategijskih opcija njene realizacije kriju i mnoga ograničenja. Imajući u vidu specifičnosti koncepta vojne neutralnosti, u radu će se analizirati osnovne teorijske postavke neutralnosti, posebnosti primene navedenog koncepta u geopolitičkoj i geostrateškoj realnosti Srbije i usklađenosti strategijsko-doktrinarnih rešenja prema navedenom dugoročnom političkom opredeljenju. Posebna pažnja biće posvećena doktrini sveobuhvatne odbrane i odvraćanju kao defanzivnom strategijsko-doktrinarnom opredeljenju koje je imanentno neutralnosti.
VOJNO NESVRSTAVANjE POJAM, RAZVOJ, PERSPEKTIVE
Authors: Jončić Miloš
Published: March 2022

Pojam vojnog nesvrstavanja, vojne nesvrstanosti ima svoje korene u pravnom institutu neutralnosti, čiji je sastavni deo vojna neutralnost. Kako bi se izbegle terminološke nedoumice autor definiše pojmove neutralnost, neutralizacija, nesvrstanost, vojna neutralnost, vojna nesvrstanost. Da bi se izbeglo pogrešno tumačenje i mešanje pojma vojna neutralnost koja podrazumeva prava i obaveze, autor iznosi mišljenje da je prihvatljiviji i precizniji termin vojno nesvrstavanje i doktrinarno to dokazuje. Rad ukazuje na društvene okolnosti i momente u međunarodnim odnosima i razvoju međunarodnog prava koji su uticali na nastanak neutralnosti. Neutralnost u savremenim međunarodnim odnosima postaje koncept koji zahteva reformu i otvara perspektivu vojnoj nesvrstanosti. Mnoge države koje su proglasile neutralnost, sve više taj koncept usmeravaju isključivo na vojnu nesvrstanost. Izmenjene okolnosti multilateralnog svetskog poretka primoravaju čak i neutralne države da se odreknu svog položaja neučestvovanja u oružanim sukobima i da se okrenu položaju nečlanstva u vojno-političkim savezima. Vojno nesvrstavanje nije moguće primenjivati povremeno ili delimično, zato rad ukazuje na neke prednosti, ali i mane ovog položaja u međunarodnim odnosima.
MAKEDONIJA U NATO: (NE)NAUČENE LEKCIJE IZ GEOPOLITIKE BALKANA
Authors: Vankovska Biljana
Published: March 2022

Priča o makedonskom uspehu ulaskom u NATO je priča o samoispunjavajućem proročanstvu: pokušavajući da izbegnu loše prognoze o opstanku države, makedonske vlasti su upravo pomogle da se stvore uslovi za ugrožavanje nacionalne bezbednosti, pa i blagostanja građana. Godinu dana u Alijansi pokazuje da je sindrom slabe države i dalje prisutan, a da je geopolitička pozicija na „liniji fronta“ slaba bezbednosna garancija za celokupnost države i nacionalnih interesa. Ovaj rad predstavlja analizu geopolitičke i geostrateške pozicije najmlađe članice NATO u regionalnom kontekstu, uz elaboraciju političkog narativa koji je pratio put ka Alijansi. Pored reality-check-a u odnosu na to što je Makedonija dobila, a šta izgubila ulaskom u NATO, u analizi će se indirektno referirati na srpsku politiku vojne neutralnosti, i uopšte na srpsku spoljnu politiku. Polazna premisa je da zemlje tzv. Zapadnog Balkana i dalje predstavljaju sistem povezanih sudova, pa se svaka promena u jednom delu regiona odražava i na sve ostale. S druge strane, slabe države ostaju sitan novčić u transakcijama velikih sila (ili bolje rečeno, korporativnog kapitala koji upravlja njima), tako da članstvo u NATO i vojna neutralnost ne predstavljaju pravi odgovor za zavisnost od zapadnih centara moći i za izgubljenog (ili uopšte nestečenog) suvereniteta. U eri dezintegracije evroatlantizma i rastućeg autoritarijanizma, jedino rešenje, ali i najnedostižnije, je uspostavljanje bliže regionalne saradnje, na političkom, kulturnom i bezbednosnom planu, što bi vodilo stvaranju balkanske bezbednosne zajednice.
STRATEŠKI OKVIRI OSPORAVANjA VOJNE NEUTRALNOSTI SRBIJE
Authors: Mitić Aleksandar , Matic Petar
Published: March 2022

Iako potvrđena rezolucijom Narodne skupštine Republike Srbije, strateškim dokumentima i izjavama srpskih i inostranih, pa i NATO zvaničnika, vojna neutralnost Srbije je istovremeno osporavana. To osporavanje je prati od usvajanja rezolucije 2007. godine, i neprestano se podgreva u nevladinim, stranačkim, ekspertskim i međunarodnim krugovima. U radu se analiziraju strateški okviri (frejmovi) koji se koriste u tu svrhu.
U analizi se istražuje da li se i kako u evroatlantskim krugovima koristi dvostruki narativ prema vojnoj neutralnosti Republike Srbije. Prvi, formalan i odobravajući. Drugi, neformalan i osporavajući. Takav dvostruki narativ balansira između, s jedne strane, težnji srpskog javnog mnjenja koje se protiv članstvu, i s druge strane, nadanja da će „politika otvorenih vrata“ za proširenje NATO ipak dati rezultata kada je u pitanju integracija Republike Srbije u ovu organizaciji. Ovakav pristup potencijalno destabilizuje koncept vojne neutralnosti Srbije ali i jača porive za njenim daljim normativnim utvrđivanjem.
Osteogenic differentiation of human dental pulp stem cells in decellularised adipose tissue solid foams
Authors:   Department of Cell Biology and Histology, Faculty of Medicine and Nursing, University of the Basque Country, UPV/EHU, Leioa, 48940, Bizkaia, Spain, Luzuriaga J , García-Gallastegui P , García-Urkia N , Pineda JR , Irastorza I , Fernandez-San-Argimiro F-J , Briz N , Olalde B , Unda F , Madarieta I , Ibarretxe G
Published: March 2022

3D cell culture systems based on biological scaffold materials obtainable from both animal and human tissues constitute very interesting tools for cell therapy and personalised medicine applications. The white adipose tissue (AT) extracellular matrix (ECM) is a very promising biomaterial for tissue engineering due to its easy accessibility, malleability and proven biological activity. In the present study, human dental pulp stem cells (hDPSCs) were combined in vitro with ECM scaffolds from porcine and human decellularised adipose tissues (pDAT, hDAT) processed as 3D solid foams, to investigate their effects on the osteogenic differentiation capacity and bone matrix production of hDPSCs, compared to single-protein-based 3D solid foams of collagen type I and conventional 2D tissue-culture-treated polystyrene plates. pDAT solid foams supported the osteogenic differentiation of hDPSCs to similar levels to collagen type I, as assessed by alkaline phosphatase and alizarin red stainings, reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) and osteocalcin/bone gamma-carboxyglutamate protein (BGLAP) immunostaining. Interestingly, hDAT solid foams showed a markedly lower capacity to sustain hDPSC osteogenic differentiation and matrix calcification and a higher capacity to support adipogenesis, as assessed by RT-qPCR and oil red O staining. White ATs from both human and porcine origins are relatively abundant and available sources of raw material to obtain high quality ECM-derived biomedical products. These biomaterials could have promising applications in tissue engineering and personalised clinical therapy for the healing and regeneration of lesions involving not only a loss of calcified bone but also its associated soft non-calcified tissues.
The Enchanting Swab Cleaner
Authors: Bhavsar Falguni , Sakalkar Mayuri , Satpute Dhanshri , Sonar Tejas , Suryawanshi Prathmesh
Published: March 2022

Abstract: Cleaning residences and the environment has become more difficult due to today's hectic routine. There are cleaners in the market now that demand humans to bend and remove spots from the floor by sprinkling their liquid to clean it. As a result, there is a pressing need to implement a cleaner that is as efficient as possible. This project has used a cost-effective way for cleaning the desired region. Hazardous locations can be cleaned using this cleanser, reducing human risks. This is accomplished by incorporating a new concept into an existing one. A pipe is attached to the lip of the bottle by the cleaner's design. Which of the following will be Which will be aided by the motor at the end of the pipe, which will pressurise the liquid and sprinkle it where it is needed. When used with a detergent cleaner, the microfiber method removed more bacteria than cotton string mops. The addition of a disinfectant had no effect on the microfibre system's germ removal. When a cotton string mop was employed, however, the use of disinfectant greatly improved germ elimination (95 percent vs 68 percent , respectively). When compared to a traditional view system, the testing results utilising a scale model show that the proposed view system can reduce work time, stoppage time, and help operators swap views more frequently and relieve their concentration from a single view. These findings imply that the proposed view system has the potential to improve productivity. The goal of this study was to evaluate the upper limb's musculoskeletal risk variables (repetitions, posture, and forces) during domestic floor mopping duties.
Pollution Study Of Near By River (Nag River)
Authors: Rahangdale Kushal , Khaire Joshua , Bhoyar Vasundhara , Patil Himani , Thakre Gajendra , Bawane Yugandhara , Parashar Gaurav , Kamble Shubham
Published: March 2022

Abstract: A nature is changing its form day by day. As we seen change in natures form, the quality of environment is depleting day by day and Environment mainly depends on the air & water. The water in the river exposes to environment during flowing and passes through various regions & may result in carrying polluted water. Water quality of river is depleting day by day due the wanted and unwanted activities of the human being. The majority of India's rivers are heavily polluted as a result of human activity, which is a huge worry. The water quality of the Nag river in Nagpur, Maharashtra, India, is determined in this project. Recently, different unending attempts have been done in this field to add Nag River to the city's historical list. This river runs through the city and serves as a waste water drainage system for Nagpur. Nagpur's urban waste pollution has severely harmed the environment of the rivers. Because such polluted waste affects all metabolic, physiological, and biological processes of aquatic organisms, it is critical to research physic-chemical features of water. The water will be tested for pH, dissolved oxygen, total dissolved solids, ammonia, and other important water quality characteristics. The effluent samples will be collected from different locations. Keywords: Quality of Water Nag River, Parameter.
Recommendation System on Questions and Answers on Social Issues with Lifestyle in the Cloud
Authors: Sahu Kapil Kumar , Tajammul Mohd
Published: March 2022

Abstract: Social Questions and Answers are a relatively recent feature on social media sites. It presents unique obstacles as well as potential for referral. In this project, we will examine the user's lifestyle. We will compute based on the results of the search. In this, we search any question, and the system reads these things and identifies the user's character. Based on this, we recommend the query to a user with a similar character. We show via trials with actual social networking sites, that social network and appears information may greatly improve the accuracy of popularity-based voting recommendations, but also that social media site information dominates corresponds information in NN-based methods. voting traces. We also discovered that chilly users value social and group information far more than heavy users. (Abstract) Keywords: Life-Style,, Aws services,
How Have Social Media Changed Communication?
Authors: Gupta Shivani , Katiyar Dr. Devesh , Goel Gaurav
Published: March 2022

Abstract: Over specific times, the manner human beings speak took numerous paperwork, which includes meeting, traveling, mailing, posting, and calling. Currently, maximum of those communications are changed with digital on line platform which include Facebook, what’s app etc. In spite of the truth that of the internet is open for every body and people appears abuse it. It is widely regular that higher procedures of conversation are on hand for us because the internet becomes made. A few Individuals help the concept folk’s affiliation thru social media, no matter the truth that others take into account this as something wrong. This studies paper will speak approximately each of those perspectives and could supply my non-public opinion. This studies paper will too delineate the additives which have pushed to the upward push of social media as a success communications medium. You can also additionally in addition to pick up information of ways social media has modified the circulation of conversation
Improving Band Ratings in Carbon Disclosure Project Reports
Authors: Upadhyay Dr. Aditya
Published: March 2022

Abstract: In 2014, only 48% of S&P companies scored high-performance band B ratings and above in their Carbon Disclosure Project (CDP) reports to attract the interest of institutional investors holding U.S. $92 trillion plus assets under management. This multiple case study explored the business leaders’ strategic decisions to improve the performance band ratings in the companies’ CDP reports. The conceptual framework for this research was stakeholder theory, which suggests that businesses should incorporate the interest of institutional investors to minimize the climate-related risks that could affect their investment decisions. The target population was business leaders from S&P 500 companies in the eastern United States who have experience in making strategic decisions to improve performance band ratings in the CDP reports. Data collection included semistructured face-to-face interviews with 4 business leaders and an exploration of company archival documents related to carbon management. Using Yin’s data analysis method 5 themes emerged: governance, risk management, target and initiatives, measurement and verification, and transparency and disclosure. These themes highlighted companies’ governing strategies for better carbon management, which are essential in achieving better performance band ratings in the CDP reports to attract the interest of intuitional investors. Better carbon management by S&P 500 companies will facilitate a positive social change by reducing greenhouse gas emissions that are detrimental to human health and well-being of its stakeholders.
Data Science Helping in Decision Making
Authors: Bhatnagar Prakhar , Katiyar Dr. Devesh , Goel Gaurav
Published: March 2022

Abstract: Technology is changing at a very fast rate. It is affecting our day to day life. It is being upgraded to make our life easier and make the things work faster. Earlier computers used to be a very simple machine with some basic tasks such as calculating, saving data and for playing games. But now many algorithms and technologies came into existence that made computers a faster, intelligent and super machines which is capable of doing tasks which humans can’t do. One such technology is Data science, earlier computers were used only to save data but analysis of that data could only be done by the humans. Data science now helped humans to get the analysis of the saved data from the computers itself. Many such algorithms and applications can be installed in the computers to analyse the data and bring out the meaningful trends from it. Keywords: Data Science, statistics, Big data, graphs, decision making
Development and Validation of RP-HPLC Method for the Simultaneous Estimation of Lansoprazole, Clarithromycin and Tinidazole in Combined Dosage Form
Authors: Dadhich Bharat , Goyal Rakesh , Agarwal Dilip
Published: March 2022

Analytical chemistry is one of the supreme branches of science which deals with the separation, identification and quantification of various natural and chemical compounds. It includes both qualitative and quantitative analysis. Quantitative analysis is having importance from the point of pharmaceutical chemistry. Quantification methods include chromatographic techniques, spectrophotometery, fluorimetery etc. One of the most popular method for quantitative analysis is High Performance Liquid Chromatography (HPLC). In this article, a reverse phase – HPLC method was developed for the simultaneous determination of Lansoprazole, Clarithromycin and Tinidazole in combined dosage form and validation of the developed method. The development of method includes selection of mobile phase, chromatographic method and wavelength whereas validation involves the parameters like linearity, accuracy, precision, Limit of detection (LOD), Limit of Quantification (LOQ), robustness, system suitability of the developed method. The result showed that the developed method is best fitted to the simultaneous determination of Lansoprazole, Clarithromycin and Tinidazole and validated as per standards.
Development and Validation of RP-HPLC Method for the Simultaneous Estimation of Methionine, Pyridoxine Hydrochloride and Nicotinamide in Combined Dosage Form
Authors: Saini Shipra , Mandal Sulekha , Agarwal Dilip
Published: March 2022

Analytical chemistry is one of the important branches of science which deals with the study of separation, identification and quantification of various natural and chemical compounds. Quantitative analysis is having supremacy from the point of pharmaceutical chemistry. Quantification methods include chromatographic techniques, spectrophotometery, fluorimetery etc. One of the accurate method for quantitative analysis is High Performance Liquid Chromatography (HPLC). In the present manuscript, a reverse phase – HPLC method was developed for the simultaneous determination of Methionine, Pyridoxine hydrochloride and Nicotinamide in combined dosage form and validation of the developed method. The development of method includes selection of mobile phase, chromatographic method and wavelength whereas validation involves the parameters like linearity, accuracy, precision, Limit of detection (LOD), Limit of Quantification (LOQ), robustness, system suitability of the developed method. The result showed that the developed method is best suited to the simultaneous determination of Methionine, Pyridoxine hydrochloride and Nicotinamide and validated as per standards.
Tuberculosis a globalized disease: Review
Authors: Nyarko Richard Owusu , Prakash Amit , Kumar Nayan , Saha Purabi , Kumar Roshan
Published: March 2022

One of the deadliest infectious diseases in the world that causes millions of deaths per year is tuberculosis (TB). In this document we present an overview of TB including pathogenesis, diagnosis and recommendations for treatment. We searched PubMed for related articles on TB in preparation for this post. We have also checked for similar reporting and clinical recommendations on the websites of international organisations such as the World Health Organization and the United States Centers for Disease Control and Prevention (CDC). The aim of this paper was to give health staff, policy-makers, patients and the public general education.
An Overview Of Phytochemical Identification Of Secondary Metabolites Ofmedicinal Plant Dactylorhiza Hatagirea
Authors: Vishwakarma Shivani , Karole Dr. Sarita
Published: March 2022

Plants are a valuable source of new natural products. Despite the availability of different approaches for the discovery of therapeutically, natural products still remain as one of the best reservoirs of new structural types. The standardized extracts of plants, provide unlimited opportunities for new drug discoveries because of the unmatched availability of chemical diversity. According to the World Health Organization (WHO), more than 80% of the world’s population relies on traditional medicine for their primary healthcare needs.HPLC is a versatile, robust, and widely used technique for the isolation of natural products, HPLC is a chromatographic technique that can separate a mixture of compounds and is used in phytochemical and analytical chemistry to identify, quantify and purify the individual components of the mixture. Currently, this technique is gaining popularity among various analytical techniques as the main choice for fingerprinting study for the quality control of herbal plants. Natural products are frequently isolated following the evaluation of a relatively crude extract in a biological assay in order to fully characterize its properties. Early studies showed that Dactylorhizahatagirea root are rich source of phytochemicals including flavonoids, phenolics, alkaloids. Therefore this study was conducted with the aim to investigate phytoconstituents present in Dactylorhizahatagirea root and assessment of their antioxidant characteristics.
Potential anti-inflammatory effects of Psidium guajava L.: A review
Authors: Souri M. Sofyan , Oktavia Sri , Ifora Ifora
Published: March 2022

Inﬂammation is a defence mechanism of a body against foreign substances. However, Inﬂammation also plays a key role in diseases such as diabetes, asthma, cardiovascular diseases, and cancer. Increasing scientiﬁc evidence has shown that fruits, vegetables, and legumes can have anti-inﬂammatory properties. This paper aims to provide recent studies on the anti-inflammatory properties of Psidium guajava L. A review was conducted on the studies of Psidium guajava L. anti-inflammatory properties performed during the past 10 years with the literature databases such as Pub Med, Science Direct, Google Scholar. Based on our eligibility criteria, a total of ten studies were included in this paper. The studies suggest that the anti-inflammatory activity of Psidium guajava occurs mainly through inhibition of PGE2, COX-2, NO, iNOS, ERK1/2, leukocyte cell migration, and suppression of edema, paw withdrawal latency as well as exhibited a membrane stabilization effect. This review has demonstrated the importance of Psidium guajava L. as a natural anti-inflammatory potential.
Orodispersible Tablets: A Compendious Review
Authors: Roshan Kenneth , Keerthy H.S
Published: March 2022

In recent times, there has been an enhanced demand for more patient compliant dosage forms. Oral route has been the gold standard in the administration of medications due to its safety, good patient compliance, ease of ingestion, pain avoidance and versatility. Dysphagia poses a problem especially in geriatric and paediatric patients. Mentally retarded patients, institutionalized patients and those travelling without access to water face a challenge as well. Orodispersible tablets are solid unit dosage form which when placed in the oral cavity swiftly disintergrates or dissolves without the need of water. ODT technology helps overcome the above mentioned challenges. Literature on ODT, their formulation and evaluation, challenges, manufacturing techniques along with patented technologies are reviewed in this article.
Elemental analysis of Andrographis echioides (L.)Nees. leaves, a potential pharmaceutical plant using atomic absorption spectroscopy (AAS).
Authors: P.S Preetha. , Kartha. A.J. Anjana
Published: March 2022

Andrographis echioides (L.) Nees.is a herbaceous plant belonging to the Acanthaceae family, which is widely used for traditional medicinal purposes. The present study was aimed to analyze the elemental composition in leaves of Andrographis echioides (L.) Nees. using atomic absorption spectroscopy (AAS)..A total of 12 elements Calcium, Iron, Magnesium, Manganese, Cadmium, Nickel, Sodium, Lead, Chromium, Zinc, Silver, and Copper have been analyzed quantitatively. The results showed that Calcium has the highest concentration among other elements analyzed. It shows the ability of this plant to maintain the proper functioning of cells in our body. It also plays an important role in the functioning of our nervous system. The concentration of iron and magnesium was also significant. Iron is an essential element for blood production and Magnesium play an important role in human body to maintain cholesterol levels, maintains heart rhythm and also has the capacity to converts blood sugar into energy. Andrographis echioides (L.) Nees. plant can be utilized for treating deficiencies of different essential macro and micro-nutrients for maintaining good health. The plant can be utilized for various other pharmaceutical purposes also.
A Review Article on Proniosome: As A Drug Carrier
Authors: Sachan Anupam Kr. , Kumar Sunil , Dwivedi Tapasya
Published: March 2022

A drug carrier is any substrate used in the process of drug delivery.  

The basic component of the drug delivery system is an appropriate drug carrier that sets out to improve the selectivity, effectiveness, and safety of drug administration. So, based on their biocompatible, biodegradable, and non-immunogenic structure, Proniosomes are promising drug carriers that are non-ionic surfactant-based multilamellar or unilamellar vesicle are now widely used as an alternative to the liposome. On the basis of structure, they are similar to liposomes in having bilayer but having chemical differences in monomer units which make Proniosomes stable. They can entrap both hydrophilic and lipophilic drugs of using either in an aqueous layer or in the vesicular membrane. Proniosomal carriers are suitable for the transdermal delivery of numerous pharmacological agents, including antioxidant, anticancer, anti-inflammatory, antimicrobial, and antibacterial molecules.
Büyük Azı-Keser Diş Hipomineralizasyonunun Tedavi Başarısı Üzerine Deproteinizasyon İşleminin ve Farklı Adeziv Sistemlerin Etkisinin Değerlendirilmesi
Authors: AKDİK Canan , CEYHAN Derya
Published: March 2022

Amaç: Bu çalışmanın amacı, çocuk hastalarda, dişin mine tabakasında inorganik içerik ve mineralizasyon yetersizliği nedeniyle oluşan büyük azı-keser diş hipomineralizasyonunun (BAKH) tedavi başarısı üzerine, deproteinizasyon işleminin ve farklı adeziv sistemlerin etkisinin değerlendirilmesidir. Materyal ve Metot: Kliniğimize başvuran ve onamı alınan hastalardan, 7-10 yaş aralığındaki, orta derecede BAKH saptanan 102’sinde, deproteinizasyon ajanı ve self-etch veya total-etch adeziv sistem kullanımına bağlı olarak 4 grup (Grup 1: NaOCl+Clearfil SE Bond+Filtek Z250, Grup 2: Clearfil SE Bond+Filtek Z250, Grup 3: NaOCl+Fosforik Asit+Prime&Bond NT+Filtek Z250, Grup 4: Fosforik Asit+Prime&Bond NT+Filtek Z250) oluşturularak restorasyonlar yapıldı. Deproteinizasyon işlemi, %5’lik NaOCl ile sağlandı. Hastalar, modifiye USPHS kriterleri ile klinik olarak değerlendirildi. Veriler istatistiksel olarak analiz edildi; p<0,05 anlamlı kabul edildi. Bulgular: Restorasyonlarda, 12 ay sonunda; anatomik form, renk uyumu, yüzey düzgünlüğü ve restorasyon sonrası duyarlılık kriterlerinde başarısızlığa rastlanmadı. Kenar bütünlüğü ve kenar renklenmesi kriterlerinde, en fazla başarı Grup 3’te gözlendi (p<0,05). Sekonder çürük kriterlerinde, Grup 1, 2 ve 3’te tüm restorasyonların başarılı olduğu, Grup 4’te ise 4 restorasyonda başarısızlık olduğu görüldü (p>0,05). Hipomineralize dişlerin tedavisinde, en başarılı grubun, deproteinizasyon işlemi ve total-etch adeziv sistem uygulanan Grup 3 olduğu anlaşıldı (p<0,05). Sonuç: BAKH tedavisinde, deproteinizasyon ve total-etch adeziv sistemlerdeki asit uygulamasının birlikte kullanımı, başarıyı arttırmaktadır. Konu ile ilgili daha fazla sayıda çalışma yapılmasına ihtiyaç vardır.
Perspectives on the problem-posing activity by prospective teachers: A cross-national study
Authors: Fitriana Linda Devi , Ekawati Rooselyna , Kovács Zoltán
Published: March 2022

There is an ongoing research interest to disclose factors that influence problem-posing performance by involving cross-national backgrounds. This research extends that effort by conducting a comparative analysis on the performance of Indonesian and Hungarian prospective teachers in a problem-posing task. A total of eighty-three prospective teachers from Indonesia and Hungary were asked to pose a problem based on the current calendar. For more in-depth insights, an interview was conducted with a representative participant. The obtained data were analysed quantitatively using Fisher's exact test and qualitatively in nature. Their mathematical background seems to influence the characteristic of their proposed problem and the solution approach they utilized. The typical tasks proposed by Indonesian prospective teachers are exercise and mostly related to arithmetic operations, while those by Hungarian prospective teachers are challenging problems and generally connected to arithmetic sequences. Moreover, in solving their problems, Indonesians tend to show arithmetic reasoning while Hungarians often denote algebraic reasoning. These disparities might be attributed to the types of problems that each group typically encounters during their mathematics lessons.
Өнгөт гэрэл үүсгэгч ашигласан синхрон удирдлагатай гурван хэмжээст Цэгэн гэрэл үүсгэгч дэлгэц
Authors: Номин-Эрдэнэ Д. , Төгөлдөр Т. , Ганбат Б.
Published: March 2022

Цэгэн гэрэл үүсгэгч (ЦГҮ) дэлгэц нь хар цагаан Spatial Light Modulator (SLM) ашигладаг учраас хар цагаан гурван хэмжээст (3D) дүрс үүсгэдэг. Өндөр үнэтэй өнгөт SLM ашиглахгүйгээр хар цагаан 3D дүрс үүсгэдэг ЦГҮ дэлгэцийн гэрэл үүсгэгчийн өнгийг улаан, ногоон, цэнхэр (RGB) болгосноор хар цагаан ЦГҮ дэлгэц нь өнгөт 3D дүрсийг үүсгэдэг болох юм. Хоёр болон түүнээс дээш тооны ялгаатай өнгийн 3D дүрс үүсгэдэг өнгөт ЦГҮ дэлгэцийг хэрэгжүүлэхдээ RGB гэрэл үүсгэгчийн өнгө болон SLM-д үзүүлэхElemental Image (EI)-үүдийг 15 Гц давтамжтайгаар синхрон удирдаж ажиллуулсан. Ингэснээр хүний нүд ялгаатай өнгөтэй 3D дүрсүүдийг харж чадсан. Бид RGB гэрэл үүсгэгч ашиглан түүнийг SLM-тэй синхрон удирдсанаар өнгөт ЦГҮ дэлгэцтэй болсон бөгөөд өнгөт SLM ашиглаагүй учраас бага өртгөөр, хялбар аргаар шийдвэрлэсэн давуу талтай.