bluuebunny/crossref_metadata_2025 huggingface dataset:
O ESTADO DEPENDENTE E AS POLÍTICAS SOCIAIS: UMA RELAÇÃO DE CONFLITOS FRENTE AO (ULTRA) NEOLIBERALISMO
Authors: Santos Eduardo Henrique Moraes , Oliveira Alan Farley Prates , Mendes Raquel de Oliveira
Published: October 2024

O presente trabalho discute a relação entre as políticas sociais e o Estado marcado pelo momento (ultra) neoliberal do capitalismo sob a ótica materialista histórica dialética, apoiada em pesquisa bibliográfica da literatura da área, com análise qualitativa. Conclui-se que as políticas sociais, enquanto instrumento criado e mantido sob o domínio do Estado Burguês, expressa um papel de conflito ao garantir os meios para a manutenção da ordem social ao tempo que oferece condições para a sobrevivência imediata dos trabalhadores, dentro da dinâmica internacional do capital. O (ultra) neoliberalismo, longe de alterar a finalidade dessa relação, tenciona giros sensíveis na organização das políticas sociais, sobretudo na influência do mercado e do Estado na sua oferta, ampliando a contradição desta relação.
COPING NO ENVELHECIMENTO: ESTRATÉGIAS DE MULHERES IDOSAS
Authors: Dias Alyne de Souza , Silva José André , Reis Jackson dos Santos , Tessarolo Mariana Medeiros Mota , Ferreira José Paulo da Silva , Scorzoni Liliana , Pais-Ribeiro José Luiz , Dias Ewerton Naves
Published: October 2024

O objetivo deste estudo foi avaliar as estratégias de coping de mulheres idosas residentes em uma cidade metropolitana de São Paulo, Brasil. Trata-se de um estudo descritivo, quantitativo e transversal, com 226 mulheres idosas. Em síntese, observou-se que as mulheres idosas utilizam predominantemente estratégias de coping focadas no problema para enfrentar as adversidades presentes nessa etapa da vida. Enfim, destaca-se a necessidade de elaborar estratégias de intervenções de cunho cognitivo e comportamental na área da psicologia positiva que contribuam para um envelhecer com saúde, bem-estar e qualidade de vida.
MANUFACTURING AND CHEMICAL CHARACTERIZATION OF ISABEL RED
Authors: Barbosa Manuella Macêdo , de Sousa Francisco Wagner , Monteiro Inês Cristielle da Cunha , Melo Pedro Augusto Barros , Fernandes Letícia Castro , Alencar Emanuelle Priscila Herculano
Published: October 2024

Considering the potential consumption and economic importance that Isabel wine represents in the Brazilian consumer market, the aim of this research was to study the manufacturing and to determine the chemistry composition of red wine produced from Isabel grapes. The wine fermentation was achieved with 0.2 g/L of Saccharomyces cerevisiae yeast at 25ºC. After seven days of fermentation the correction of sugar was performed. After 40 days, the wine was separated from residues. The wine was clarified with commercial unflavored gelatin at the proportion of 0.2 g/L. The parameters total and volatile acidities, ethanol, dry extract, carotenoids, anthocyanins, total phenolic and reducing sugar were studied. Isabel grapes have the potential to be used to produce wine, hence its economic importance in Brazil. The chemical profile provided essential information about the Isabel red wine and the yeast used for inoculation result in good must fermentation, according to Brazilian legislation.
ANÁLISE DO PERFIL DOS ESTUDANTES DE CONTABILIDADE DO CENTRO UNIVERSITÁRIO UNIFACVEST
Authors: Fernandez Benjamin Nataniel Dimer , de Ramos Ezequiel Lins no S , de Moura Matheus Francisco de Lima , de Oliveira Ruan Borges , Rodrigues Renato
Published: October 2024

Esse artigo busca trazer total fidelidade ao assunto tratado, trazendo discussões por meio de uma pesquisa quantitativa realizada na disciplina de Metodologia da Pesquisa e do Trabalho Científico, pelos próprios estudantes do Centro Universitário Unifacvest, com o intuito de entender o perfil do acadêmico de contabilidade de todas as fases da instituição. O leitor poderá embarcar em uma leitura altamente rica em conhecimento, trazendo dados interessantes do que se passa na mente dos estudantes, dentre eles um perfil de acadêmicos que buscam uma maior projeção no mercado de trabalho. O estudo pode fornecer ideias e tirar dúvidas, daqueles que podem se interessar pela matéria de ciências contábeis, principalmente aos futuros estudantes, que por sua vez, podem ter dúvidas sobre a dificuldade do curso e a percepção dos acadêmicos a respeito do corpo docente da Instituição. Outro fato interessante, são os dados apresentados como as grandes taxas de empregabilidade, para aqueles que são formados na área, que podem influenciar positivamente aqueles que desejam ingressar neste curso. Participaram da pesquisa 75 alunos do curso de graduação de Contabilidade do Centro Universitário Unifacvest, o que corresponde a 81,75% dos alunos ativos no curso.
PERSPECTIVAS CRÍTICAS SOBRE O DIREITO, EDUCAÇÃO E RELAÇÕES DE TRABALHO NA FORMAÇÃO CIDADÃ
Authors: Rodrigues Renato , Rodrigues Gabriél Silva , Rodrigues Neto Artur , da Silva Edi , Varela Giséle do Amaral
Published: October 2024

Este artigo revisita e expande de forma crítica a discussão sobre a interseção entre educação, cidadania, relações de trabalho e cultura no contexto contemporâneo. Enfatiza-se a necessidade de uma abordagem complexa e multifacetada, evidenciando o papel fundamental dos gestores educacionais na promoção de transformações sociais significativas por meio de seu engajamento ativo e dinâmico com a comunidade. O objetivo central é investigar como os atores do processo de ensino-aprendizagem percebem e se relacionam com o trabalho e a cidadania, reconhecendo o potencial das escolas básicas em promover uma compreensão profunda e crítica do direito, cidadania e suas implicações culturais, gerenciais e educacionais. Ao fazer isso, o artigo busca delinear estratégias inovadoras que possam desafiar e reconfigurar as práticas pedagógicas atuais, promovendo uma educação mais inclusiva e voltada para a justiça social.
ROBÓTICA GAMIFICADA: UM CAMINHO EFICAZ PARA O ENSINO DE PROGRAMAÇÃO NO ENSINO FUNDAMENTAL
Authors: Malta Daniela Paula de Lima Nunes , Silva Neto Jorge Sales e , Cardoso Maria do Socorro Fernandes , Cabral Ana Rosa Sales , da Costa Thiago Ranzani , França Erivelton Fernandes
Published: October 2024

O presente estudo examina a eficácia da robótica gamificada como método de ensino de programação para alunos do ensino fundamental. Utilizando uma abordagem metodológica mista, o estudo comparou um grupo experimental, que participou de um programa de voo de lazer semiestruturado, com um grupo controle. Os resultados mostraram um aumento significativo no conhecimento de programação e habilidades relacionadas no grupo experimental, com uma melhoria média de 42% nos resultados dos testes, em comparação com 12% no grupo de controle. Observou-se um elevado nível de envolvimento e motivação intrínseca entre os participantes, com 92% a expressar o desejo de continuar a aprender o programa através desta abordagem. A análise qualitativa revelou melhorias na colaboração, comunicação e resolução de problemas, bem como uma mudança positiva nas atitudes dos alunos face a erros e desafios. Os projetos finais demonstraram criatividade e aplicação prática dos conceitos aprendidos. Apesar dos resultados promissores, o estudo reconhece limitações em termos de tamanho da amostra e duração da intervenção, o que indica a necessidade de novos estudos em maior escala. Conclui-se que a robótica divertida tem um potencial significativo como método de ensino de programação, proporcionando um ambiente de aprendizagem atrativo e eficaz que não só ensina competências técnicas, mas também promove competências essenciais para o século XXI.
O PAPEL DO PROFESSOR NA ERA DAS TECNOLOGIAS EMERGENTES: DESAFIOS E OPORTUNIDADES PARA RECONFIGURAR O ENSINO E A APRENDIZAGEM
Authors: Demuner Jocelino Antonio , Gomes Jefferson de Souza , da Silva Claudia Kreuzberg , da Cruz Neila Aparecida , dos Reis Domingos Aparecido , de Souza Maria de Fátima
Published: October 2024

O advento das tecnologias emergentes tem transformado profundamente o cenário educacional, redefinindo o papel do professor e as práticas pedagógicas. Este estudo teve como objetivo analisar o papel do professor na era das tecnologias emergentes, identificando desafios, oportunidades e perspectivas futuras para sua integração no processo de ensino-aprendizagem. A pesquisa adotou uma abordagem qualitativa, baseada em uma revisão bibliográfica sistemática de fontes acadêmicas brasileiras dos últimos 10 anos, incluindo artigos, teses e dissertações. Os resultados indicaram que o papel do professor, longe de ser diminuído, torna-se mais complexo e crucial, evoluindo para o de um facilitador, curador de conteúdos e arquiteto de experiências de aprendizagem. Observou-se que a integração eficaz das tecnologias emergentes depende significativamente da formação continuada dos professores e da implementação de políticas educacionais adequadas. Desafios importantes foram identificados, incluindo a necessidade de desenvolver novas competências digitais, adaptar metodologias de ensino e lidar com questões éticas e de privacidade. A pesquisa também destacou o potencial das tecnologias emergentes para promover uma educação mais personalizada, colaborativa e inclusiva. Concluiu-se que o futuro da educação na era digital requer uma abordagem equilibrada, que valorize o papel insubstituível do professor enquanto aproveita as oportunidades oferecidas pelas tecnologias emergentes para enriquecer e transformar o processo educativo.
ANÁLISE DE PROCESSAMENTO VISUAL E APRENDIZADO DE MÁQUINA NO DIAGNÓSTICO PRECOCE DO TEA USANDO RASTREAMENTO OCULAR
Authors: Nogueira Filho Ariomar da Luz , Pizo Gerardo Antonio Idrobo , Cardoso Leandro Xavier , da Silva Marlete Maria , da Motta José Maurício Santos Torres
Published: October 2024

Este estudo não clínico explora a eficácia do processamento holístico no reconhecimento facial e a aplicação de sistemas de rastreamento ocular no diagnóstico do Transtorno do Espectro Autista (TEA). São adotadas três abordagens: Faces Compostas, Part-to-Whole e Efeito de Inversão, destacando a importância de análises holísticas para um reconhecimento facial eficiente. A pesquisa utiliza sistemas de rastreamento ocular baseados em câmeras, notáveis por sua abordagem não invasiva e precisão em detectar movimentos oculares específicos. Empregam-se o software OGAMA® e ferramentas de mineração de dados como o Orange Canvas para analisar métricas oculares. A metodologia inclui a identificação, armazenamento e processamento de variáveis oculométricas usando algoritmos de aprendizado supervisionado para prever padrões comportamentais em indivíduos com TEA. Os experimentos realizados demonstraram a eficácia da metodologia proposta. Dados de referência foram utilizados para validar as descobertas, e técnicas de aprendizado de máquina foram empregadas para diferenciar indivíduos com TEA, destacando-se as Redes Neurais como o algoritmo mais eficaz. Conclui-se que a combinação de rastreamento ocular com mineração de dados oferece insights valiosos para o diagnóstico e compreensão do TEA, abrindo novas possibilidades para a pesquisa em processamento holístico e contribuindo significativamente para as áreas de psicologia, medicina e tecnologias assistivas.
CONTRIBUIÇÕES DA PERSPECTIVA ELIASIANA PARA A SOCIOLOGIA DA TRADUÇÃO
Authors: da Costa Junior Euluze Rodrigues , Célio Sobrinho Reginaldo , Lamonica Priscila Andressa Muzy de Almeida
Published: October 2024

Este ensaio tem por objetivo evidenciar os constructos eliasianos que podem servir de ferramentas de fundamentação teórico-metodológicas para as investigações da Sociologia da Tradução. A partir da compreensão de que a tradução é uma prática social, recorremos a estudos nacionais e internacionais, que constituem o adensamento da discussão que propomos com ricas questões norteadoras desenvolvidas no campo da sociologia, especialmente, aquelas decorrentes do pensamento bourdieusiano. Nessa caminhada, tecemos aproximações peculiares desse subcampo de produção do conhecimento dos Estudos da Tradução com a Sociologia Figuracional de Norbert Elias, especialmente, com as noções de figuração, rede de interdependência e habitus. Sem perder de vista a superação da dicotomia indivíduo e sociedade, concluímos com indicações de possíveis investigações em torno das traduções e dos tradutores.
CONSIDERAÇÕES SOBRE A FISIOGRAFIA E AS FITOFISIONOMIAS DO MUNICIPIO DE VITORIA DA CONQUISTA – BA
Authors: Cardoso Sayonara Marques , da Nobrega Marcelo Araujo
Published: October 2024

O presente trabalho faz algumas considerações sobre a fisiografia, o clima e as fitofisionomias do município de vitória da Conquista – BA. Foi realizado uma pesquisa bibliográfica sobre a temática da região e trabalhos de campo para tomada de fotografias das fitofisionomias do município em questão. A tipologia climática varia de úmido a semiárido de leste a oeste, tendo muita influência topográfica nas massas de ar. Os solos normalmente são profundos e ácidos, exceto os da zona da Caatinga. O município é diverso em termos geológicos, geomorfológicos, climáticos resultando em diversas fitofisionomias. A caatinga predomina no oeste do município e no norte, a floresta decídua e semidecídua é encontrada sobretudo no Planalto da Conquista, e a floresta ombrófila densa no leste do município. Poucas áreas estão com a vegetação preservada, sendo a maior parte degradada, sem vegetação, com pastagens ou agricultura, e zonas urbanizadas ou suburbanizadas.
SOLVÊNCIA ORÇAMENTÁRIA DA PREFEITURA DE GOIÂNIA (2014-2023): AVALIAÇÃO DO EQUILÍBRIO ORÇAMENTÁRIO E PERFORMANCE DA PREVISÃO E EXECUÇÃO
Authors: Silva Damarys de Oliveira , de Oliveira Johnny Jorge
Published: October 2024

Este artigo tem como objetivo avaliar a solvência orçamentária da Prefeitura de Goiânia no período de 2014 a 2023, com base na análise do equilíbrio entre a previsão e a execução de receitas e despesas. A pesquisa foi motivada pela necessidade de compreender a sustentabilidade fiscal do município e identificar os principais desafios enfrentados na gestão financeira. Utilizando dados das Demonstrações Contábeis Aplicadas ao Setor Público (DCASP) e aplicando indicadores de Lima e Diniz (2016), a pesquisa adota uma abordagem quantitativa, com ênfase na análise financeira comparativa. Foram analisados indicadores de receita e despesa, como desempenho de arrecadação, eficiência na arrecadação e grau de cobertura dos créditos adicionais. Os resultados apontam uma boa execução orçamentária nas despesas correntes e alta eficiência na arrecadação, mas também revelam desafios relacionados à diversificação de receitas e dificuldades em cobrir créditos adicionais. Conclui-se que ajustes no planejamento e maior flexibilidade fiscal são necessários para enfrentar futuros desafios econômicos e garantir a sustentabilidade fiscal a longo prazo.
THE DIFFERENT APPROACHES IN THE TREATMENT OF HYPERTROPHIC SCARS AND KELOIDS
Authors: Vaz Amanda Souto , Oliveira Igor Chaves Dias , Barreto Luma Solidade
Published: October 2024

The treatment of keloids and hypertrophic scars represents an ongoing challenge in dermatology and plastic surgery. This article reviews current therapeutic approaches and recent innovations in the treatment of these conditions. The efficacy of combination therapy, the use of botulinum toxin and other therapeutic advances are discussed. The information is based on a comprehensive analysis of recent studies and articles, focusing on pathophysiology, risk factors, and management strategies. Method:To achieve the objective of this study, which is a literature review, the PubMed and MedLine databases were used, using the following descriptors: "Hypertrophic Scars" AND "Keloids" AND "Keloid Treatment".
SYSTEMIC SCLEROSIS
Authors: Blanc Gabriela Cortines , de Araújo Bruna Lima Eiras
Published: October 2024

Systemic sclerosis (SSc) is a rare connective tissue disease of unknown etiology, heterogeneous clinical manifestations, and chronic evolution, often progressive.1,6 It is characterized by inflammatory, fibrotic, and atrophic changes.6 The onset of the disease is more common in the age group of 30 to 50 years, and is more prevalent in women. SSc has been reported in all geographic areas and in all races, but it has been observed that the black race has a higher chance of developing it.1.4 SSc can compromise the connective tissue of various organs such as the skin, lungs, heart, gastrointestinal, renal and musculoskeletal tracts.8 In addition, it is classified into two subtypes, the diffuse and limited forms, and it is the extent of skin thickening that differentiates these two. In 10% of patients, the skin is normal, no thickening occurs, and it is called scleroderma sine sclero.4 As it is a disease that affects multiple systems, it imposes limitations on the affected individual and affects their quality of life. Proper diagnosis is very important, since the manifestations can be varied and with some possible differential diagnoses.
NEGLECT IN THE MENTAL AND PHYSICAL HEALTH CARE OF HEALTH PROFESSIONALS
Authors: Leal Mirela Ambrósio , de Souza Fernanda de Freitas Medeiros , Lima Filho Vivaldo Palma , Lordão Samuel Batista Monte Alto do Vale , André Maria Eduarda Guizelini , Sarni Ana Flávia Souto Fonseca , Ribeiro Dener de Freitas , Lima Cintya dos Santos
Published: October 2024

The health area is composed of a multiprofessional team, and each sector of activity has an extreme impact on the quality of life of each patient, considering that their demands are also multidisciplinary. However, even with the stratification of care and division of functions among the responsible team, there is still a significant overload of health professionals, especially in the hospital setting. This overload is reflected in factors such as professional exhaustion or burnout syndrome, which is one of the pillars of neglect regarding physical and mental self-care among health professionals. Likewise, lack of time, poor pay, lack of professional appreciation, poor working conditions, and emotional overload are other examples of factors that contribute to this scenario. With this in mind, this study aims to review the main conditions associated with the self-neglect of health professionals, with regard to physical and mental health, bringing together factors common to all areas of activity and with emphasis on nursing and medical services.
THE PRESENCE OF CLEFT PALATE: PHYSICAL AND SOCIAL CONSEQUENCES
Authors: Silva Matheus Santos , de Queiroz Netto João , Tonet Mariely
Published: October 2024

Introduction: The presence of cleft palate has several consequences for the integral development of the individual who is born with this anomaly, and in turn they vary from the impact on physical and social integrity. Methods: The theoretical framework used the SciELO and PubMed databases to search for studies from 2001 to 2023, in English and Portuguese. Discussion: The consequences of cleft palate are not widely disseminated, so it is insufficiently addressed, the impacts on phonation, breathing and mental health are serious and impact mortality rates. Cheiloplasty is one of the surgeries of choice and the presence of more procedures depends on the extent of the anomaly. Even so, early diagnosis and preparation of the family and the team that will assist the patient are of paramount importance to minimize such impacts. Conclusion: It is concluded that the presence of cleft palate is an enormous challenge for the patient and their companions. The insecurity and physical and social challenges demonstrate the importance of the surgical procedure.
URBANIZATION AND LOCAL AND REGIONAL DEVELOPMENT OF SOUTHEASTERN MEXICO
Authors: Corona Javier Pérez
Published: October 2024

In the multi-scale national urban scenario, the urbanization of the southeast region stands out due to the accelerated dynamics in a rural/dispersed and contrasting environment between metropolization and numerous ethnic localities and indigenous communities in precarious social and environmental conditions, but which have socio-territorial resources, attractive to investment in strategic sectors: oil, agribusiness and tourism services; along with infrastructure projects of mobility and transportation. Urbanization that rethinks development between forms of dispossession of common goods and the resistance of native peoples in their ways of life and territorial habitation. Local and regional development that puts in perspective to face the contradictions of developmentalism and alternatives from the subalternity. What characteristics redefine singular urbanization from rural/dispersed population centers and the forms of municipal development of indigenous communities of regional scope? To this end, the determinants of urbanization are examined with demographic dynamics and the structure of human settlements in agglomeration/dispersal areas and the social/ethnic profile, to identify development trends. A statistical review of the population and localities and conditions of access to common goods is carried out; together with planning/public works in community municipalities. Some results highlight trends of extended urbanization and persistence of concentration/dispersion, but with intermunicipal articulation due to infrastructural undertakings and some progress in local development, due to social/community cohesion.
EFECTIVIDAD DE LA ENSEÑANZA COMBINADA DEL APRENDIZAJE BASADO EN PROBLEMAS (ABP) Y BASADO EN ERRORES (ABE) EN GINECOLOGÍA
Authors: Vargas-Vera Ramón Miguel , Patiño Freddy Alberto Cabrera , Placencia-Ibadango Silvia Maribel , Placencia Saul Alexander Alencastro , Placencia-Ibadango Martha Verónica , Bravo Adriana Leonor Sarango , Placencia Jocelyn Maribel Alencastro , Vargas-Silva Kalid Stefano , Mancero Gonzalo Xavier Fernández , Vargas-Silva Kathiuska Stefany , Zambrano-Burbano Moisés Steven
Published: October 2024

El objetivo de este estudio fue determinar si la enseñanza combinada ABP-ABE fue efectiva en los estudiantes de ginecología. Metodología Se llevó a cabo un estudio prospectivo y observacional con 200 estudiantes de ginecología del décimo semestre e internados, que se dividieron aleatoriamente en dos grupos para el sistema combinado ABP-ABE y el grupo tradicional. Se realizaron encuestas previas y posteriores a la clase para evaluar sus percepciones y experiencias con el método. Resultados: En el cuestionario previo a clase, el sistema tradicional obtuvo puntuaciones significativamente más altas que el grupo ABP-ABE (75.34 frente 70.43 y 35.43 frente 23.34), P = 6.39x10-5). En el grupo ABP-ABE, las puntuaciones de conocimientos básicos y análisis de casos aumentaron significativamente, 72.23 frente a 68.51 y 31.23 frente a 30.24, respectivamente (P 0.612). El grupo ABP-ABE mejoró mucho más que el grupo tradicional; el ABP-ABE experimentó un aumento de 70.43 a 72.23 en comparación con el tradicional de 75.43 a 68.51. Por otro lado, en cuanto al tiempo dedicado a la clase, el sistema ABP-ABE obtuvo puntuaciones significativamente más bajas que el sistema tradicional (P < 0,001). Conclusión: ABP junto con ABE puede ser un método efectivo para mejorar el rendimiento y las habilidades clínicas de los estudiantes e internos de medicina.
IMPACT OF THE COVID-19 PANDEMIC ON PEDIATRIC DENTAL CARE AND THE USE OF MINIMALLY EVASIVE PROCEDURES IN BRAZIL
Authors: de Souza André Sobrinho , Balbino Anne Karoliny Silva , Moraes Darah Sathler Alvim , Miyakawa Gabriela Silva , de Amorim Julia Fernanda Cotta , Balbino Kartesiany Silva , Pivetta Lariza , Milleri Daniela Pertel
Published: October 2024

Considering the COVID-19 pandemic that generated direct impacts on the health area, pediatric dentistry was also affected, since the transmission of the virus occurs from droplets and aerosols from an infected individual. In this way, extra protocols and safety measures were put in place before and during treatment to minimize the spread of infection among dentists, patients and other health professionals. In pediatric dental care, some authors suggest the use of minimally invasive procedures (MIPs) in the management of caries lesions. Therefore, the objective of this study is to review the literature on the impact of the COVID-19 pandemic on the provision of pediatric dental care, and the use of minimally invasive procedures, as an alternative for care in dental offices. To this end, an integrative review study was carried out, in which a bibliographic survey was carried out in the Scielo, Lilacs, Pubmed databases from 2020 to 2024. Thus, it is observed that the COVID-19 pandemic has caused significant changes in children's diet, difficulties in accessing oral health services, and the need to change pediatric dental care protocols, several studies suggest the option for minimally invasive dental procedures, which have the advantage of reducing or eliminating the production of aerosols, with less risk of contamination for professionals, patients and guardians.
ATRAZINE AS AN ENDOCRINE DISRUPTOR AND ITS EFFECTS ON MALE REPRODUCTIVE HEALTH
Authors: Pedrozo Aniely Loiza , Oda Humberto Manabu , Dogan Nasle , Matusiaki Weslen Fernandes da Silva , Inoue Miriam Hiroko
Published: October 2024

Atrazine has been widely used in Brazilian agriculture, especially in corn and soybean crops. Due to its widespread use, this literature review is relevant to systematize the main studies that evaluate the impact of atrazine as an endocrine disruptor leading to changes in fertility quality, especially in males. In several tests and studies carried out with the exposure of animals to atrazine, negative effects related to changes in factors that are essential for male fertility were observed. Therefore, inhibition of the hypothalamic-pituitary-testicular axis, decreased reproductive cells’s metabolic activity, reduced testosterone levels, reduced lactate dehydrogenase (LDH) enzyme, negative effects on spermatogenesis and morphological changes in the gonads and sperm are results of atrazine toxicity on the male reproductive system that contribute to infertility. In general, it is concluded that atrazine has a potential endocrine disruptor effect, leading to changes in the form of hormone production, especially in hormones related to male sexual reproduction. For this reason, assessing the risks of exposure to this toxin at different stages of life and over several generations, combined with knowledge of its pathophysiological mechanism on the male reproductive system, is essential to preserve the reproductive health of future generations.
Green tea (Camellia sinensis) leaf extract inhibits the activity of β-lactamases
Authors: Nisa Faiz Un , Javid Amina , Mehboob Ahmed
Published: October 2024

The most emerging resistance mechanism against β-lactam antibiotics present in bacteria is the production of β-lactamases. The aim of this study was to explore the phytocompounds of Camellia sinensis (green tea) that can inhibit the activity of β-lactamases. Moreover, the antibacterial effect of its extract with a combination of antibiotics against resistant bacterial strains was also appraised. In silico docking was carried out against the resistance causing enzymes such as AmpC and SHV-1. Antimicrobial susceptibility testing against bacterial strains, i.e., Klebsiella pneumoniae and Escherichia coli, was performed. Then, for exploring the synergistic effects, both antibiotics and green tea extract were applied in combination. The docking studies revealed that the inhibitors like epigallocatechin gallate with AmpC, and myricetin with SHV-1 enzyme displayed high binding affinities of -8.2 kJ/mol, and -7.5 kJ/mol, respectively. The in vitro combination of C. sinensis extract with ampicillin and penicillin also potentiated the antibacterial activity of these antibiotics. Thus, the study elucidated that the phytochemicals of C. sinensis could inhibit β-lactamases produced by the pathogens. Also, it has enhanced antimicrobial effects when combined with antibiotics.
Faire silence : approches interdisciplinaires d’une action qui ne dit pas son nom
Authors:   Centre de Savoirs sur le Politique. Recherches et Analyses (EHESS-CNRS), Puccio-Den Deborah , Debiais Vincent ,   Centre de recherches historiques (EHESS-CNRS)
Published: October 2024

L’introduction de ce numéro décrit la genèse du projet de recherche collectif sur le silence mené à l’École des hautes études en sciences sociales depuis 2020 dans le cadre de l’équipe international triennale « Arts et Intelligences du Silence ». Elle pose également les grandes lignes théoriques des recherches sur le silence dans le domaine des sciences humaines et sociales en signalant les contributions majeures qui en ont posé les bases. L’introduction propose enfin un bref survol des articles rassemblés dans le dossier, pointe les résultats les plus significatifs des études proposées par les auteurs et les autrices, et signale les directions dans lesquelles poursuivre les recherches.
Silence du déplacement et technologies de la terreur
Authors:   Laboratoire d’Anthropologie Politique (LAP-CNRS-EHESS), Beneï Véronique
Published: October 2024

À partir de matériaux ethnographiques recueillis et co-construits au long cours (années 2000 et 2010) sur la problématique du déplacement forcé des populations en Colombie, cet article propose de réinterroger le silence comme « potentialité pleine » : une potentialité révélant un espace d’expériences vécues qui ne peuvent être dites que dans des seuils liminaires, hors des lieux et moments de sociabilité ordinaire. Sont également explorées diverses temporalités du silence dans ce contexte et comment leurs dynamiques peuvent rouvrir un espace de parole jusque-là tue. Les pratiques de (mise sous) silence, les technologies de la terreur et, plus largement, les violences auxquelles donne lieu le phénomène du déplacement sont ici étudiées parmi les personnes déplacées comme celles qui ne l’ont pas vécu. En documentant l’expérience phénoménologique qu’elles font respectivement du silence, une observation attentive à la médiation des corps en situation d’énonciation donne à en percevoir les différentes textures, épaisseurs et « tessitures », et le potentiel afférent d’activation, voire de libération, de la parole.
Antioxidant potential and fatty acid composition of Lactarius sanguifluus
Authors: Canpolat Sükrü , Düşgün Cihan , Ildız Elif , Yürümez Canpolat Elif , İşlek Cemil
Published: October 2024

Edible mushrooms have been valued as a source of food and traditional medicines since ancient times. Mushrooms have drawn the attention of numerous researchers in recent decades since they contain a variety of bioactive compounds with antibacterial, antiallergic, antidiabetic, antitumoral, and antioxidant activities. As a member of the Russulaceae family Lactarius sanguifluus (Paulet) Fr. (1838) (also known as bloody milk cap) is an ectomycorrhizal edible mushroom distributed in Asia, the Mediterranean shores and mid-Europe. In this study it was aimed to identify the mushroom sample both by physical traits according to the current literature and by molecular techniques. The antioxidant capability of L. sanguifluus methanol extract was evaluated by stable radical scavenging activity and metal ion reducing capability methods. The content of total phenolic compounds and the fatty acid composition of the mushroom sample were also investigated. The mushroom sample was identified both by comparing the physical traits with the current literature and by comparing the sequence data of the ITS region of rDNA with GenBank. The methanol extract of the dried mushroom sample was used to perform the analysis to determine the antioxidant activity and content of total phenolic compounds. It was found that L. sanguifluus methanol extract contained 3.677±0.207 mg GAE/g DW phenolic compounds and exhibited radical scavenging activities as 211.652±0.537 mg TE/g DW against DPPH and 73.389±1.003 mg TE/g DW against ABTS. L. sanguifluus methanol extract also had metal ion reducing capabilities with ferric reducing and cupric reducing antioxidant capacities of 191.903±0.659 mg AAE/g DW and 379.598±7.527 mg TE/g DW, respectively. The GC-MS analysis of the hexane extract of the mushroom sample revealed that palmitic acid, linoleic acid, oleic acid and stearic acid were the predominant fatty acids found in L. sanguifluus.
Irisin levels in type 2 diabetes mellitus with and without non-alcoholic fatty liver disease: a case-control study
Authors: Nayak Saffalya , Sahu Pratima Kumari , Roma Rattan  , Mahapatra Srikrushna , Mohapatra Debjyoti
Published: October 2024

Background: Fatty liver disease, particularly non-alcoholic fatty liver disease (NAFLD), affects around 25% of adults globally and up to 40% in developed countries. Often coexisting with type 2 diabetes mellitus (T2DM), NAFLD is linked to insulin resistance and metabolic syndrome. Irisin, a myokine induced by exercise, shows promise in enhancing insulin sensitivity, reducing hepatic steatosis, and improving metabolic health. Despite its potential, further research is needed to fully understand irisin's mechanisms and clinical implications in NAFLD and T2DM.
Objectives: This study investigates the irisin levels in T2DM patients with and without NAFLD and compares them with healthy controls.
Methods: A case-control study has been conducted involving 90 T2DM patients and 90 healthy controls, aged 30-55 years, recruited from SCB Medical College, Cuttack, between September 2021 and August 2022. Participants were screened for NAFLD using the Hepatosis Steatosis Index (HSI) and divided into four groups: T2DM with NAFLD, T2DM without NAFLD, controls with NAFLD, and controls without NAFLD. Serum irisin levels were measured using ELISA. Anthropometric data, physical activity, and various biochemical parameters were assessed and analyzed.
Results: The irisin levels were significantly lower in T2DM patients compared to healthy controls (p = 0.001). Among T2DM patients, those with NAFLD had lower irisin levels than those without NAFLD, though not statistically significant (p = 0.299). Significant correlations were observed between irisin levels and insulin sensitivity markers such as HOMA-IR and QUICKI across different groups.
Conclusion: Lower irisin levels in T2DM patients, particularly those with NAFLD, highlight its potential role in the pathogenesis of metabolic disorders. Further research is needed to elucidate irisin's therapeutic implications in T2DM and NAFLD.
УНИКАЛЬНОСТЬ СОСТАВА КОЗЬЕГО МОЛОКА И ПРЕИМУЩЕСТВА ИСПОЛЬЗОВАНИЯ ФОРМУЛ НА ЕГО ОСНОВЕ У МЛАДЕНЦЕВ, ЛИШЕННЫХ ГРУДНОГО МОЛОКА
Authors: Богданова Наталья Михайловна
Published: October 2024

В статье представлен обзор научной литературы по особенностям состава козьего молока. Отмечено, что цельное молоко любых сельскохозяйственных животных, в том числе и коз, не рекомендовано для употребления детьми грудного возраста, так как их состав не соответствует грудному молоку и организм младенцев не способен к адекватному перевариванию и усвоению филогенетически не предусмотренной пищи. Отражено, что применение инновационных технологий при производстве адаптированных молочных формул на основе козьего молока для младенцев позволяет сохранить все естественные ценные компоненты сырья. Приведены клинические исследования, подтверждающие эффективность использования стартовых формул на основе козьего молока.

The article presents a review of the scientifi c literature on the peculiarities of the composition of goat’s milk. It is noted that whole milk of any farm animals, including goats, is not recommended for use by infants, since their composition does not correspond to breast milk and the body of infants is not capable of adequate digestion and assimilation of phylogenetically unsupported food. It is refl ected that the use of innovative technologies in the production of adapted dairy formulas based on goat’s milk for infants allows you to preserve all the natural valuable components of raw materials. Clinical studies confi rming the eff ectiveness of using starter formulas based on goat’s milk are presented.
К ЮБИЛЕЮ ПРОФЕССОРА ГУЗЕВОЙ ВАЛЕНТИНЫ ИВАНОВНЫ
Authors: Гузева Оксана Валентиновна , Гузева Виктория Валентиновна , Разумовский Михаил Анатольевич , Охрим Инна Владимировна
Published: October 2024

К ЮБИЛЕЮ ПРОФЕССОРА ГУЗЕВОЙ ВАЛЕНТИНЫ ИВАНОВНЫ

FOR THE ANNIVERSARY OF PROFESSOR VALENTINA IVANOVNA GUZEVA
Fintech Aplikasi Jaklingko Dalam Bisnis Transportasi Umum Dan Kaitannya Dengan Inovasi Terbuka
Authors: Purwaningsih Eny , Saputra Dita Wahyu , Wahyudi Ickhsanto , Syahzuni Barlia Annis
Published: October 2024

Kemajuan teknologi digital telah mengubah paradigma dalam berbagai sektor, termasuk industri keuangan dengan munculnya Financial Technology (FinTech). Di Indonesia, pertumbuhan urbanisasi dan kepemilikan kendaraan pribadi di Jakarta telah menyebabkan masalah serius dalam sistem transportasi perkotaan. Terutama terkait dengan kemacetan sehingga membutuhkan inovasi baru seperti pembayaran digital sebagai solusinya. Penelitian ini menginvestigasi faktor-faktor yang mempengaruhi adopsi layanan FinTech melalui aplikasi JakLingko, dalam konteks transportasi umum di DKI Jakarta, dengan melibatkan 185 responden. Menggunakan pendekatan kuantitatif dan SEM-PLS dengan software SmartPLS untuk pengujiannya. Berdasarkan teori UTAUT2 yang diperbarui, variabel seperti Performance Expectancy, Effort Expectancy, Facilitation Condition, Price Value, dan Knowledge terbukti memiliki pengaruh signifikan terhadap Fintech Adoption. Sementara variabel seperti Social Influence, Hedonic Motivation, Habit, dan Perceived Security tidak menunjukkan pengaruh yang signifikan. Selain itu, Fintech Adoption mempengaruhi Business Sustainability transportasi umum. Hasil ini memberikan wawasan mendalam tentang dinamika adopsi teknologi FinTech di sektor transportasi umum. Implikasi dari temuan ini adalah pentingnya pemerintah dan penyedia layanan transportasi memahami faktor-faktor ini untuk meningkatkan efisiensi operasional dan pengalaman pengguna dalam penggunaan pembayaran digital di sektor transportasi umum, sehingga mendukung Business Sustainability dan peningkatan layanan transportasi di Jakarta.
Krisis Kesehatan Jiwa dalam Dinamika Peraturan Perundang-Undangan di Indonesia
Authors: Wijayanto Enggar , Sriharini
Published: October 2024

Isu kesehatan jiwa menjadi studi kasus yang bersifat multidimensi, dimana banyak aspek yang terdampak secara individu dan sosial. Indonesia menjadi salah satu negara dengan risiko permasalahan kesehatan jiwa yang cukup tinggi. Hal disebabkan masih minimnya serta atensi serta kesiapan fasilitas pendukung, salah satunya  instrumen kebijakan. Maka,tulisan ini akan menganalisis bagaimana masalah kesehatan jiwa dalam dinamika politik hukum pasca Undang-Undang Nomor 17 Tahun 2023 tentang Kesehatan, serta responsibilitas arah kebijakannya. Metode penelitian di dalam artikel ini menggunakan model library research dengan sumber data yang diperoleh melalui penelusuran data sekunder dengan pendekatan yuridis-normatif. Hasil penelitian menunjukan bahwa negara memiliki tanggung jawab untuk secara responsif mengatasi masalah kesehatan jiwa yang tidak dapat dikesampingkan dari upaya pemberdayaan kesehatan nasional secara holistik. Perhatian melalui formulasi kebijakan terhadap kesehatan jiwa terkait dengan perlindungan kesehatan jiwa adalah pemberdayaan sumber daya manusia untuk terciptanya generasi yang sehat tidak hanya secara fisik melainkan mental sebagaimana tujuan bernegara yang di cita-citakan. Kesimpulan penelitian ini adalah peraturan turunan UU Kesehatan terkait layanan kesehatan jiwa harus segera diaktualisasikan guna mencegah masalah kesehatan jiwa semakin luas.
The Effect Of Product Quality And Price On Coal Purchase Interest Through Sales Based On Non-Kai Logistics At Pt Bukit Asam, Tbk
Authors: Haryadi Rendra , Widiyanti Marlina , Shihab Muchsin Saggaff , Maulana Ahmad
Published: October 2024

This study aims to analyze the effect of product quality and price on coal purchase interest through non-KAI-based logistics sales at PT Bukit Asam, Tbk. The background of this research is driven by the challenges faced by the company in increasing purchase interest through more flexible distribution strategies and reducing reliance on railway transportation. The research method used is quantitative, with data collected through surveys of 150 respondents, consisting of customers and brokers. Data analysis was conducted using multiple linear regression. The results show that product quality and price positively and significantly impact coal purchase interest. High product quality has been proven to enhance customer satisfaction, while competitive pricing is crucial in attracting consumer interest. In conclusion, PT Bukit Asam, Tbk, should continue to improve service quality and offer more competitive prices to expand its market and increase sales through the non-KAI logistics system.
LARGE INFERIOR RECTUS RECESSION WITHOUT LOWER LID RETRACTION: TWO INCREDIBLE TECHNIQUES
Authors: Gokyigit Birsen , Kutlutürk Gizem
Published: October 2024

Relevance. Lower lid retraction is a frequent undesirable result following inferior rectus recession operations. Especially in relatively larger amounts of recession, a special and close relationship between lower lid retractors and muscular fascia makes the complication more severe. 
Purpose of the study. To introduce two methods that allow wide inferior rectus recession without causing lower eyelid retraction and to evaluate the long-term results.
Material and methods. There were 25 cases and 18 control group cases in first operation technique named ‘ninety percent of posterior fibers recession of inferior rectus’ which can be perform for any vertical deviation without muscle fibrosis; and 8 cases were in second operation technique which named ‘muscle elongation with both organic tissue and non-absorbable suture’.
Results and conclusion. In both technique patients’ deviation corrected and all ocular movement was free. Both operation techniques, which introduces by us, does not affected lower lid retractor and operations has both effective results and no lid problem.
ENDOSKOPIK ENDONASAL DAKRIOSISTORINOSTOMIYADA DAKRIOSTOMA YARATISHNING TURLI USULLARINI QIYOSIY TAHLILI
Authors: Juraev T.B. , Yusupov A.F. , Timurov M.N. , Maxkamova D.K.
Published: October 2024

Dolzarbligi. Hozirgi vaqtda endoskopik endonazal dakriosistorinostomia (EndoDCR) surunkali dakriosistitni jarrohlik davolashning samarali usuli hisoblanadi. Bu dakriostoma sohasida (DS) tiklanish jarayonlarining o'ziga xos kechishi va burun bo'shlig'ida sinexiyalarning shakllanishi tufayli yuzaga keladi.
Tadqiqot maqsadi. Surunkali dakriotsistit bilan og'rigan bemorlarda endoskopik endonazal dakriosistorinostomia jarrohligida dakriostoma yaratishning optimal usulini aniqlash.
Materiallar va usullar. Tadqiqot materialiga dakriosistitli 30 nafar bemor kiritilgan bo'lib, ular bajarilgan operatsiyaga qarab 3 guruhga bo'lingan.
Natijalar. Tadqiqot natijalariga ko'ra, optimallashtirilgan lakrimal implant, ya'ni dakriostomani kengaytiruvchi vosita nafaqat dakriostoma qirralarining yopishishini oldini oladi, balki kasalliklarni davolashda zamonaviy amaliyotda qo'llaniladigan mavjud lakrimal implantatlardan farqli o'laroq lakrimal kanallarning burun bo'shlig'ida sinexiya shakllanishiga to'sqinlik qiladi.
Xulosa.Ushbu kombinirlangan usuldan foydalangan holda jarrohlik aralashuvi natijasida 90,0% hollarda to`liq sog`ayishga erishildi, bu boshqa guruhdagi jarrohlik usullariga (DS ni faqat ko`z yosh qopi medial devorining bir qismini plastikasi hisobiga shakillatnirish – 50%, DS ni ko`z yosh qopi medial devorini bir qismini olib tashlab bikanalikulyar silikon implant intubatsiyasi bilan hosil qilish – 70%) nisbatan yuqori natija hisoblanadi.
СУРУНКАЛИ ВИРУСЛИ ГЕПАТИТЛАРДА УЧРАЙДИГАН ЁШГА БОҒЛИҚ МАКУЛАДИСТРОФИЯНИ КОМПЛЕКС ДАВОЛАШНИ САМАРАДОРЛИГИНИ ОШИРИШ
Authors: Ахмедов Т.Б. , Каримова М.Х. , Хусанбаев Х.Ш. , Солиев Т.Ю. , Собиров О.О.
Published: October 2024

Долзарблиги. Ҳар йили 1 миллионга яқин одам гепатит В вируси асоратларидан вафот этади, бу эса барча ўлим сабаблари орасида 10 ўринни эгаллайди.
Тадқиқот мақсади. Сурункали жигар касалликлари учрайдиган ЁМД клиник кечишини гепатопротектор ва ретинопротектор кўллаган ҳолатда самарадорлигини баҳолаш.
Материал ва усуллар. ЁМД қуруқ шакли бошланғич даври СГС ривожланиш даражаси II босқич бўлган 46 та, ўртача ёши 50,5±2,7 бўлган беморлар. Асосий гурух жами 23 та (36 та кўз)  беморлардан иборат бу гурухга бир вақтни ўзида гептрал ва окувайт форте бир йил давомида қўлланилди. Назорат гурух 23 та (42 та кўз) беморларга эса фақатгина окувайт форте бир йил давомида бериб борилди. Барча беморлар стандарт офтальмологик текширувлар билан бирга, порогли периметрия ва ОСТ текширувидан ўтказилди. Кўриш майдонини текшириш АР-3000 автоматик периметр ускунасида, «30-2 SITA standard» дастури асосида 30 градус майдондаги 76 та фиксация нуқталарини нур сезувчанлик ҳусусиятини (MD, MS, PSD, VFI) аниқлайди.
Натижалар ва ҳулоса. Асосий гурух беморларда КЎМК 4 ой давомида 0.01, 8 ой давомида 0.01±0.02, 12 ой давомида 0.02±0.01 га кўтарилган. Назорат гурух беморларда эса КЎМК тушиб бориши, яъни 4 ой ичида 0.04±0.01, 8 ой ичида 0.07±0.02, 12 ой ичида 0.09±0.01 аниқланди. Сурункали жигар касалликлари учрайдиган ЁМД беморларга бир вақтнинг ўзида гепатопротектор ва ретинопротектор кўллаш орқали тўр парда морфо-функционал холати яхшиланиши аниқланди. Гепатопротекторлар таъсирида жигар биофункцияси яхшиланиб, жигар оркали ўтадиган дори воситалар трансформацияси мўътадиллашади.
НЕЙРОМЕТАБОЛОМИКА ПРИ ГЛАУКОМНОЙ ОПТИЧЕСКОЙ НЕЙРОПАТИИ (ОБЗОР ЛИТЕРАТУРЫ)
Authors: Ахмедова Ш.А. , Юсупов А.Ф. , Каримова М.Х. , Махкамова Д.К.
Published: October 2024

Проблема глаукомы имеет большое медико-социальное значение ввиду широкой распространенности и тяжести исходов заболевания, нередко ведущих к слепоте и инвалидности. В статье рассматриваются литературные данные по изучению нейрометаболомики при глаукоме и глаукомной оптической нейропатии. Таким образом, можно сделать вывод, что метаболомика дает ценную информацию о метаболических изменениях, связанных с глаукомой, потенциально открывая путь к новым диагностическим и терапевтическим подходам для улучшения результатов лечения пациентов с этим угрожающим зрению заболеванием.
КОНЦЕПТУАЛЬНЫЙ ПОДХОД К ДИАГНОСТИКЕ И ЛЕЧЕНИЮ МИКСТ-ИНФЕКЦИОННЫХ ВОСПАЛИТЕЛЬНЫХ ЗАБОЛЕВАНИЙ ОРГАНА ЗРЕНИЯ
Authors: Бабаханова Д.М. , Камилов Х.М. , Максудова Л.М. , Ражабов У.Р.
Published: October 2024

Актуальность. Поражения органа зрениямикст-инфекцией представляют значительные трудности вследствие сходства клинических проявлений и чрезвычайной резистентности к терапии. Помимо медикаментозного лечения эффективными оказались малоинвазивные вмешательства: пластика аутоконъюнктивой,амнионом или ксенотранслантатом. Цель исследования. Анализ клинических случаев микст-инфекционных поражений глаз. Материал и методы. В исследовании участвовали 43 пациентов с язвой роговицы, получавших лечение в РКОБ и Термезском филиале РСНПМЦМГ в 2017-2023 годах. Всем пациентам проведены стандартные исследования: визиометрия, рефрактометрия, офтальмоскопия, тонометрия, А-В сканирование, исследована проходимость слёзных путей, по показаниям ультрозвуковой биомикроскопии (УБМ) переднего отдела глаза и передняя ОКТ. Результаты и заключение. В результате исследований установлено: при микробиологическом исследовании содержимого конъюнктивальной полости в 2 случаях обнаружена кишечная палочка, в 17–микст-инфекция (стафилококки и грибки), в 3 - Pseudomona saeruginosa, в 2 – грибковая инфекция. Иммунологический анализ крови обнаружил повышение титров антител (IgG) к вирусу простого герпеса у 12 (28%) и цитомегаловирусу у 6 (14%) пациентов. При угрозе перфорации роговицы (11 пациентов – 25,9%) производилось покрытие очага мобилизованной аутоконъюнктивой с блефароррафией. В случаях перфорации (4 пациента – 9,3%) производилось покрытие дефекта роговицы амнионом или ксенотрансплантатом. В 2 (4,6%) случаях процесс закончился эвисцерацией глаза.