bluuebunny/crossref_metadata_2025 huggingface dataset:
Case Report: Remdesivir and Convalescent Plasma in a Newly Acute B Lymphoblastic Leukemia Diagnosis With Concomitant Sars-CoV-2 Infection
Authors: Dell'Isola Giovanni Battista , Felicioni Matteo , Ferraro Luigi , Capolsini Ilaria , Cerri Carla , Gurdo Grazia , Mastrodicasa Elena , Massei Maria Speranza , Perruccio Katia , Brogna Mariangela , Mercuri Alessandra , Pasqua Barbara Luciani , Gorello Paolo , Caniglia Maurizio , Verrotti Alberto , Arcioni Francesco
Published: August 2021

Introduction:The spread of Covid-19 has worsened the prognosis of oncology patients, interrupting or delaying life-saving therapies and contextually increasing the risk of severe SARS-CoV-2 infections. Acute lymphoblastic leukemia (ALL) is the most frequent cancer in pediatric age and the management of this disease with concomitant SARS-COV-2 infection represents a challenging situation.

Case presentation:We present the case of a 6-year-old female newly diagnosed with ALL during a documented SARS-CoV-2 infection. Our patient was admitted 20 days after SARS-CoV-2 detection for evening-rise fever. Laboratory testing showed severe neutropenia while chest x-ray detected moderate pulmonary involvement. Acute lymphoblastic leukemia diagnosis was made through morphological and molecular analysis on bone marrow aspirate. Given the stability of the blood count and clinical conditions, antiviral therapy with Remdesivir and Convalescent Plasma was started before antileukemic treatment, obtaining a rapid resolution of the infection.

Conclusion:In our experience, the treatment with Remdesivir and Convalescent Plasma led to a rapid resolution of Sars-Cov-2 infection. Our case did not present any adverse event to the therapy. Thus, this treatment could be considered in patients with malignancies, in order to accelerate the resolution of the infection and begin immunosuppressive treatment safely. Further studies are required to confirm this hypothesis.
Physical Activity as a Preventive Lifestyle Intervention Acts Through Specific Exosomal miRNA Species—Evidence From Human Short- and Long-Term Pilot Studies
Authors: Garai Kitti , Adam Zoltan , Herczeg Robert , Banfai Krisztina , Gyebrovszki Adam , Gyenesei Attila , Pongracz Judit E. , Wilhelm Marta , Kvell Krisztian
Published: August 2021

Exercise initiates systemic adaptation to promote health and prevent various lifestyle-related chronic diseases. Emerging evidence suggests that circulating exosomes mediate some of the beneficial effects of exercise via the transfer of microRNAs between tissues. Yet to date, a comprehensive profile of the exosomal miRNA (exomiR) content released following short-term (0.5 year in this study) and long-term (25 + years in this study) regular bouts of exercise is still lacking. However, a better understanding of these miRNA species would assist in clarifying the role of regular exercise at the molecular level in the prevention of chronic diseases. In the present pilot studies we analyzed serum exomiR expression in healthy young, sedentary participants (n = 14; age: 23 ± 2 years) at baseline and following a half year-long moderate-intensity regular exercise training. We also analyzed serum exomiR expression in older, healthy trained participants (seniors, n = 11; age: 62 ± 6 years) who engaged in endurance activities for at least 25 years. Following the isolation and enrichment of serum exosomes using Total Exosome Isolation Reagent (TEI) their exomiR levels were determined using the amplification-free Nanostring platform. Hierarchical cluster analysis revealed that the majority of exomiRs overlap for short-term (0.5 year in this study) and long-term (25 + years in this study) regular bouts of exercise. The top 12 significantly altered exomiRs (let-7a-5p; let-7g-5p; miR-130a-3p; miR-142-3p; miR-150-5p; miR-15a-5p; miR-15b-5p; miR-199a-3p; miR-199b-3p; miR-223-3p; miR-23a-3p, and miR-451a-3p) were used for further evaluation. According to KEGG pathway analysis a large portion of the exomiRs target chronic diseases including cancer, neurodegenerative and metabolic diseases, and viral infections. Our results provide evidence that exosomal miRNA modulation is the molecular mechanism through which regular exercise prevents various chronic diseases. The possibility of using such exomiRs to target diseases is of great interest. While further validation is needed, our comprehensive exomiR study presents, for the first time, the disease-preventive molecular pattern of both short and long-term regular exercise.
Democracy Under Attack: Challenges of Addressing Ethical Issues of AI and Big Data for More Democratic Digital Media and Societies
Authors: Christodoulou Eleni , Iordanou Kalypso
Published: August 2021

The potency and potential of digital media to contribute to democracy has recently come under intense scrutiny. In the context of rising populism, extremism, digital surveillance and manipulation of data, there has been a shift towards more critical approaches to digital media including its producers and consumers. This shift, concomitant with calls for a path toward digital well-being, warrants a closer investigation into the study of the ethical issues arising from Artificial Intelligence (AI) and Big Data. The use of Big Data and AI in digital media are often incongruent with fundamental democratic principles and human rights. The dominant paradigm is one of covert exploitation, erosion of individual agency and autonomy, and a sheer lack of transparency and accountability, reminiscent of authoritarian dynamics rather than of a digital well-being with equal and active participation of informed citizens. Our paper contributes to the promising research landscape that seeks to address these ethical issues by providing an in-depth analysis of the challenges that stakeholders are faced with when attempts are made to mitigate the negative implications of Big Data and AI. Rich empirical evidence collected from six focus groups, across Europe, with key stakeholders in the area of shaping ethical dimensions of technology, provide useful insights into elucidating the multifaceted dilemmas, tensions and obstacles that stakeholders are confronted with when being tasked to address ethical issues of digital media, with a focus on AI and Big Data. Identifying, discussing and explicating these challenges is a crucial and necessary step if researchers and policymakers are to envisage and design ways and policies to overcome them. Our findings enrich the academic discourse and are useful for practitioners engaging in the pursuit of responsible innovation that protects the well-being of its users while defending the democratic foundations which are at stake.
The Interactive Management of the SARS-CoV-2 Virus: The Social Cohesion Index, a Methodological-Operational Proposal
Authors: Turchi Gian Piero , Dalla Riva Marta Silvia , Ciloni Caterina , Moro Christian , Orrù Luisa
Published: August 2021

This contribution places itself within the emergency context of the COVID-19 spread. Until medical research identifies a cure acting at an organic level, it is necessary to manage what the emergency generates among the members of the Community in interactive terms in a scientific and methodologically well-founded way. This is in order to promote, among the members of the Community, the pursuit of the common aim of reducing the spread of infection, with a view to community health as a whole. In addition, being at the level of interactions enables us to move towards a change of these interactions in response to the COVID-19 emergency, in order to manage what will happen in the future, in terms of changes in the interactive arrangements after the emergency itself. This becomes possible by shifting away from the use of deterministic-causal references to the use of the uncertainty of interaction as an epistemological foundation principle. Managing the interactive (and non-organic) fallout of the emergency in the Community is made possible by the formalisation of the interactive modalities (the Discursive Repertories) offered by Dialogical Science. To place oneself within this scientific panorama enables interaction measurements: so, the interaction measurement indexes offers a range of generative possibilities of realities built by the speeches of the Community members. Moreover, the Social Cohesion measurement index, in the area of Dialogical Science, makes available to public policies the shared measure of how and by how much the Community is moving towards the common purpose of reducing the contagion spread, rather than moving towards other personal and not shared goals (for instance, having a walk in spite of the lockdown). In this index, the interaction between the Discursive Repertories and the “cohesion weight” associated with them offers a Cohesion output: the data allow to manage operationally what happens in the Community in a shared way and in anticipation, without leaving the interactions between its members to chance. In this way, they can be directed towards the common purpose through appropriate interventions relevant to the interactive set-up described in the data. The Cohesion measure makes it possible to operate effectively and efficiently, thanks to the possibility of monitoring the progress of the interventions implemented and evaluating their effectiveness. In addition, the use of predictive Machine Learning models, applied to interactive cohesion data, allows for immediate and efficient availability of the measure itself, optimising time and resources.
Melodic Universals Emerge or Are Sustained Through Cultural Evolution
Authors: Verhoef Tessa , Ravignani Andrea
Published: August 2021

To understand why music is structured the way it is, we need an explanation that accounts for both the universality and variability found in musical traditions. Here we test whether statistical universals that have been identified for melodic structures in music can emerge as a result of cultural adaptation to human biases through iterated learning. We use data from an experiment in which artificial whistled systems, where sounds produced with a slide whistle were learned by human participants and transmitted multiple times from person to person. These sets of whistled signals needed to be memorised and recalled and the reproductions of one participant were used as the input set for the next. We tested for the emergence of seven different melodic features, such as discrete pitches, motivic patterns, or phrase repetition, and found some evidence for the presence of most of these statistical universals. We interpret this as promising evidence that, similarly to rhythmic universals, iterated learning experiments can also unearth melodic statistical universals. More, ideally cross-cultural, experiments are nonetheless needed. Simulating the cultural transmission of artificial proto-musical systems can help unravel the origins of universal tendencies in musical structures.
Attending a Biopsychosocially Focused Buprenorphine Training Improves Clinician Attitudes
Authors: Russell Holly Ann , Smith Brian , Sanders Mechelle , Loomis Elizabeth
Published: August 2021

Objective: Substance use disorders remain highly stigmatized. Access to medications for opioid use disorder is poor. There are many barriers to expanding access including stigma and lack of medical education about substance use disorders. We enriched the existing, federally required, training for clinicians to prescribe buprenorphine with a biopsychosocial focus in order to decrease stigma and expand access to medications for opioid use disorder.

Methods: We trained a family medicine team to deliver an enriched version of the existing buprenorphine waiver curriculum. The waiver training was integrated into the curriculum for all University of Rochester physician and nurse practitioner family medicine residents and also offered to University of Rochester residents and faculty in other disciplines and regionally. We used the Brief Substance Abuse Attitudes Survey to collect baseline and post-training data.

Outcomes: 140 training participants completed attitude surveys. The overall attitude score increased significantly from pre to post-training. Additionally, significant changes were observed in non-moralism from pre-training (M = 20.07) to post-training (M = 20.98, p < 0.001); treatment optimism from pre-training (M = 21.56) to post-training (M = 22.33, p < 0.001); and treatment interventions from pre-training (M = 31.03) to post-training (M = 32.10, p < 0.001).

Conclusion: Increasing medical education around Opioid Use Disorder using a Family Medicine trained team with a biopsychosocial focus can improve provider attitudes around substance use disorders. Enriching training with cases may improve treatment optimism and may help overcome the documented barriers to prescribing medications for opioid use disorder and increase access for patients to lifesaving treatments.
Effectiveness of an Individual Cognitive-Behavioral Intervention for Serious, Young Male Violent Offenders: Randomized Controlled Study With Twenty-Four-Month Follow-Up
Authors: Lardén Martin , Högström Jens , Långström Niklas
Published: August 2021

Background:Psychological recidivism-reducing interventions with serious, young violent offenders in residential care have unsatisfactory effects. We tested if a complementary individual cognitive behavioral therapy (iCBT) intervention focusing problem-solving, cognitive self-control, and relapse prevention reduces criminal recidivism beyond usual institutional care encompassing interventions such as social skills training and prosocial modeling (treatment-as-usual; TAU).

Method:We consecutively approached 115 eligible serious, male violent crime offenders in five residential treatment homes run by the Swedish National Board of Institutional Care. Eighty-one (70%) 16 to 21-year-old youth at medium-high violent recidivism risk were included and randomized to an individualized 15 to 20-session CBT intervention plus TAU (n= 38) or to TAU-only (n= 43), 4–6 months before release to the community. Participants were assessed pre- and post-treatment, at 12 months (self-reported aggressive behavior, reconvictions) and 24 months (reconvictions) after release. Intent-to-treat analyses were applied.

Results:The violent reconviction rate was slightly higher for iCBT+TAU vs. TAU-only youth at 12 months (34 vs. 23%,d= 0.30, 95% CI: −0.24 to 0.84) and 24 months following release (50 vs. 40%,d= 0.23, 95% CI: −0.25 to 0.72), but neither of these differences were significant. Cox regression modeling also suggested non-significantly, negligibly to slightly more violent, and any criminal recidivism in iCBT+TAU vs. TAU-only youth during the entire follow-up. Further, we found no significant between-group differences in conduct problems, aggression, and antisocial cognitions, although both iCBT+TAU and TAU-only participants reported small to large within-group reductions across outcome measures at post-treatment. Finally, the 12-month follow-up suggested marginally more DSM-5 Conduct Disorder (CD) symptoms of “aggression to people and animals” in iCBT+TAU vs. TAU-only youth (d= 0.10, 95% CI: −0.40 to 0.60) although this difference was not significant.

Conclusion:We found no additive effect of individual CBT beyond group-based TAU in residential psychological treatment for serious, young male violent offenders. Limited sample size and substantial treatment dropout reduced the robustness of intent-to-treat effect estimates. We discuss the possible impact of treatment dose and integrity, participant retention, and TAU quality.
Sense of Coherence and Burnout in Healthcare Professionals in the COVID-19 Era
Authors: Stoyanova Kristina , Stoyanov Drozdstoy Stoyanov
Published: August 2021

Emotional exhaustion in the context of vulnerability to burnout is a part of the universal narrative of high stress and systematically reported in healthcare professionals. The sense of coherence (SOC) is a salutogenic construct, operationalized by A. Antonovsky as a generalized resistance resource (GRR) to stress in three dimensions: meaningfulness (Me), the desire of a person to be motivated to cope; comprehensibility (C), the belief that the challenge is understood; and manageability (Ma), the belief that coping resources are available. The relation between SOC and the dimensions of burnout—Emotional Exhaustion (EE), Depersonalization (D), and Personal Accomplishment (PA)—is a part of salutogenic functioning, which reveals the inner motivation and self-organization of the psycho-emotional energetic resource. This study traces the salutogenic functioning of Bulgarian healthcare professionals during the pandemic. A general psychological background of coherence and exhaustion has been identified. All components of the SOC were positively correlated to Personal Accomplishment. Emotional Exhaustion and Depersonalization correlated negatively with coherence. SOC was validated as a possible determinant to predict the reduction of exhaustion and depersonalization as well as high levels of professional performance. The dimension of Meaningfulness in the coherence phenomenon was demonstrated to have the highest predictive value for professional burnout.
A Cross-Sectional Survey on Professionals to Assess Health Needs of Newly Arrived Migrants in Spain
Authors: Serre-Delcor Núria , Oliveira Inés , Moreno Ruben , Treviño Begoña , Hajdók Eva , Esteban Esperanza , Murias-Closas Adrià , Denial Abdallah , Evangelidou Stella
Published: August 2021

Heightened conflicts and lack of safety due to reasons related to economic, social, ethnic, religious, sexual orientation, political, or nationality matters have increased migratory movements during the last, few decades. Unfortunately, when migrants arrive in new territories, they can face many barriers. For example, in Spain, some migrants have difficulties in accessing health services. The main objective of this study was to describe, from the perspective of social and healthcare professionals, health needs and barriers faced among migrants who recently arrived in Spain when accessing the health system. To accomplish this aim, we carried out a cross-sectional descriptive study using a newly created self-administered questionnaire. Statistical analysis was done using the SPSS 23.00® program. Survey collection was from April 2018 to October 2018, and the cohort comprised a total of 228 professionals. Most participants were females (76%), with an average age of 35 years [interquartile range (IQR) 29.8–43.0]. The most represented profession in the cohort was physician (48%), followed by social care professionals (32%), nursing (11%), and other (8%). Of these individuals, 61% stated having either little or limited knowledge of international migrant health rights, and 94% believed migrants must overcome barriers to receive health services. The four most reported barriers were as follows: language, cultural differences, administrative issues, and fear of being undocumented. Additionally, by order of importance, professionals viewed mental health disorders and infectious diseases as the most common contributors to disease burden in this group. The four most popular strategies implemented by professionals to improve healthcare access further for migrants included intercultural competency training for professionals; access to community health agents; access to translators; and development of health system navigation skills among those newly arrived. Study results suggest that governments should make greater efforts to provide social and healthcare professionals with more effective tools that overcome communication barriers and cultural competence training modules.
An Empirical Study of Economic Cycle, Air Quality, and National Health Since Reform and Opening Up
Authors: Chai Kuang-Cheng , Li Qiang , Bao Xing-Li , Zhu Jiawei , He Xing-Xing
Published: August 2021

Since the reform and opening up of China, the economy has continued to grow, and diverse needs have generated different types and periods of economic activities. This has caused people to have an unhealthy diet, lack of exercise, irregular work and rest, lack of sleep, mental stress, high psychological pressure, long-term bad moods, and other health problems. The proportion of the sub-healthy population continues to increase and health problems are becoming increasingly prominent. Based on this, we examine the internal mechanism of the economic cycle on national health since the reform and opening up of China. For a long time, China has actively responded to the UN's call for environmental protection and proposed that “clear waters and lush mountains are invaluable assets.” Therefore, this study combines air quality in the process of environmental governance in China to investigate national health. Data from 22 provinces, five autonomous regions, and four municipalities from 2004 to 2017 are selected as research samples to examine the relationship between economic cycles, air quality, and national health for empirical testing. Studies have shown that the economic cycle is significantly correlated with national health. The better the macroeconomy, the better the health of the human body; that is, the lower the unemployment rate, the lower the mortality rate. After introducing air quality, it was found to have a significant regulating effect on the relationship between the economic cycle and national health. Our conclusions reveal that economic development is closely related to national health. China should attach great significance to the environment and air quality in the process of economic development to achieve sustainable development and create a green economy.
Genetic Relationship Between Endometriosis and Melanoma
Authors: Yang Fei , Mortlock Sally , MacGregor Stuart , Iles Mark M. , Landi Maria Teresa , Shi Jianxin , Law Matthew H. , Montgomery Grant W.
Published: August 2021

Epidemiological studies have observed that risk of endometriosis is associated with history of cutaneous melanoma and vice versa. Evidence for shared biological mechanisms between the two traits is limited. The aim of this study was to investigate the genetic correlation and causal relationship between endometriosis and melanoma. Summary statistics from genome-wide association meta-analyses (GWAS) for endometriosis and melanoma were used to estimate the genetic correlation between the traits and Mendelian randomization was used to test for a causal association. When using summary statistics from separate female and male melanoma cohorts we identified a significant positive genetic correlation between melanoma in females and endometriosis (rg = 0.144, se = 0.065, p = 0.025). However, we find no evidence of a correlation between endometriosis and melanoma in males or a combined melanoma dataset. Endometriosis was not genetically correlated with skin color, red hair, childhood sunburn occasions, ease of skin tanning, or nevus count suggesting that the correlation between endometriosis and melanoma in females is unlikely to be influenced by pigmentary traits. Mendelian Randomization analyses also provided evidence for a relationship between the genetic risk of melanoma in females and endometriosis. Colocalization analysis identified 27 genomic loci jointly associated with the two diseases regions that contain different causal variants influencing each trait independently. This study provides evidence of a small genetic correlation and relationship between the genetic risk of melanoma in females and endometriosis. Genetic risk does not equate to disease occurrence and differences in the pathogenesis and age of onset of both diseases means it is unlikely that occurrence of melanoma causes endometriosis. This study instead provides evidence that having an increased genetic risk for melanoma in females is related to increased risk of endometriosis. Larger GWAS studies with increased power will be required to further investigate these associations.
Solar-Wind Structures That Are Not Destroyed by the Action of Solar-Wind Turbulence
Authors: Borovsky Joseph E.
Published: August 2021

If MHD turbulence is a dominant process acting in the solar wind between the Sun and 1 AU, then the destruction and regeneration of structure in the solar-wind plasma is expected. Six types of solar-wind structure at 1 AU that are not destroyed by turbulence are examined: 1) corotating-interaction-region stream interfaces, 2) periodic density structures, 3) magnetic structure anisotropy, 4) ion-composition boundaries and their co-located current sheets, 5) strahl-intensity boundaries and their co-located current sheets, and 6) non-evolving Alfvénic magnetic structure. Implications for the solar wind and for turbulence in the solar wind are highlighted and a call for critical future solar-wind measurements is given.
Behavior Selection Metaheuristic Search Algorithm for the Pollination Optimization: A Simulation Case of Cocoa Flowers
Authors: Syafruddin Willa Ariela , Paweroi Rio Mukhtarom , Köppen Mario
Published: August 2021

Since nature is an excellent source of inspiration for optimization methods, many optimization algorithms have been proposed, are inspired by nature, and are modified to solve various optimization problems. This paper uses metaheuristics in a new field inspired by nature; more precisely, we use pollination optimization in cocoa plants. The cocoa plant was chosen as the object since its flower type differs from other kinds of flowers, for example, by using cross-pollination. This complex relationship between plants and pollinators also renders pollination a real-world problem for chocolate production. Therefore, this study first identified the underlying optimization problem as a deferred fitness problem, where the quality of a potential solution cannot be immediately determined. Then, the study investigates how metaheuristic algorithms derived from three well-known techniques perform when applied to the flower pollination problem. The three techniques examined here are Swarm Intelligence Algorithms, Individual Random Search, and Multi-Agent Systems search. We then compare the behavior of these various search methods based on the results of pollination simulations. The criteria are the number of pollinated flowers for the trees and the amount and fairness of nectar pickup for the pollinator. Our results show that Multi-Agent System performs notably better than other methods. The result of this study are insights into the co-evolution of behaviors for the collaborative pollination task. We also foresee that this investigation can also help farmers increase chocolate production by developing methods to attract and promote pollinators.
Impact of Chelating Agent Salt Type on the Enhanced Oil Recovery from Carbonate and Sandstone Reservoirs
Authors: Hassan Amjed , Mahmoud Mohamed , Patil Shirish
Published: August 2021

In this paper, chelating agents were introduced as standalone fluids for enhancing the oil recovery from carbonate and sandstone reservoirs. Chelating agents such as glutamic acid di-acetic acid (GLDA), ethylene-diamine-tetra acetic acid (EDTA), and hydroxyl-ethylethylene-diamine-tri-acetic acid (HEDTA) were used. Chelating agents can be found in different forms such as sodium, potassium, or calcium salts. There is a significant gap in the literature about the influence of salt type on the hydrocarbon recovery from carbonate and sandstone reservoirs. In this study, the impact of the salt type of GLDA chelating agent on the oil recovery was investigated. Potassium-, sodium-, and calcium-based high-pH GLDA solutions were used. Coreflooding experiments were conducted at high-pressure high-temperature (HPHT) conditions using carbonate and sandstone cores. The used samples had porosity values of 15–18%, and permeability values were between 10 and 75 mD. Seawater was injected as a secondary recovery process. Thereafter, a GLDA solution was injected in tertiary mode, until no more oil was recovered. In addition to the recovery experiments, the collected effluent was analyzed for cations concentrations such as calcium, magnesium, and iron. Moreover, dynamic adsorption, interfacial tension, and contact angle measurements were conducted for the different forms of GLDA chelating agent solutions. The results of this study showed that incremental oil recovery between 19% and 32% of the Original Oil in Place (OOIP) can be achieved, based on the salt type and the rock lithology. Flooding carbonate rocks with the calcium-based GLDA chelating agent yielded the highest oil recovery (32% of OOIP), followed by that with potassium-based GLDA chelating agent, and the sodium-based GLDA chelating agent yielded the lowest oil recovery. The reason behind that was the adsorption of the calcium-based GLDA on the rock surface was the highest without reducing the rock permeability, which was indicated by the contact angle, dynamic adsorption, and flooding experiments. The outcome of this study will help in maximizing the oil recovery from carbonate and sandstone reservoirs by suggesting the most suitable salt type of chelating agents.
Well Knowledge of the Physiology of Actinobacillus succinogenes to Improve Succinic Acid Production
Authors: Salma Alaa , Djelal Hayet , Abdallah Rawa , Fourcade Florence , Amrane Abdeltif
Published: August 2021

The anaerobic fermentation of glucose and fructose was performed by Actinobacillus succinogenes 130Z in batch mode using three different volume of bioreactors (0.25, 1 and 3 L). The strategy used was the addition of MgCO3 and fumaric acid (FA) as mineral carbon and the precursor of succinic acid, respectively, in the culture media. Kinetics and yields of succinic acid (SA) production in the presence of sugars in a relevant synthetic medium were investigated. Work on the bench scale (3 L) showed the best results when compared to the small anaerobic reactor’s succinic acid yield and productivity after 96 h of fermentation. For an equal mixture of glucose and fructose used as substrate at 0.4 mol L−1 with the addition of FA as enhancer and under proven optimal conditions (pH 6.8, T = 37 °C, anaerobic condition and 1% v/v of biomass), about 0.5 mol L−1 of SA was obtained, while the theoretical production of succinic acid was 0.74 mol L−1. This concentration corresponded to an experimental yield of 0.88 (mol-C SA/mol-C sugars consumed anaerobically) and a volumetric productivity of 0.48 g-SA L−1 h−1. The succinic acid yield and concentration obtained were significant and in the order of those reported in the literature.
UAV Thrust Model Identification Using Spectrogram Analysis
Authors: Pizetta Igor Henrique Beloti , Brandão Alexandre Santos , Sarcinelli-Filho Mário
Published: August 2021

This paper deals with a non-contact method to identify the aerodynamic propeller constants of the Parrot AR.Drone quadrotor. The experimental setup consists of a microphone installed in the flight arena to record audio data. In terms of methodology, a spectrogram analysis is adopted to estimate the propeller velocity based on the filtered sound signal. It is known that, in a hovering maneuver, when the UAV mass increases, the propellers rotate faster to produce the necessary thrust increment. In this work, the rotorcraft takes off with its factory settings, first with no hull, corresponding to a mass of 413 g, and after with a small hull, corresponding to a mass of 444 g, and a bigger hull, corresponding to a mass of 462 g. In the sequence, the velocity of the propellers are estimated for each of these three cases using spectrograms of audio recorded by a microphone, corresponding to the sound generated by the four rotors. Finally, the estimated velocity is used to identify the aerodynamic parameters, thus validating the proposal.
The Axioms in My Understanding from Many Years of Experience
Authors: Dimitrov Boyan
Published: August 2021

This is a discussion article that should raise more questions than answers. We write our own point of view about the concept of axioms. We list several examples, mostly known to readers, and focus on examples where the axioms produce separate areas of studies and applications. The classic definitions are schematically presented since these are well known. We briefly notice how they generated various other fields of development. Set theory is, in our opinion, the fundamental for new areas of development. Our focus is on some recent axioms such as uncertainty, probability, and new concepts and results related to these fields. The emphasis is on the meaning of an undefined concept and on its measuring.
Anti-Platelet Properties of Apple Must/Skin Yeasts and of Their Fermented Apple Cider Products
Authors: Moran Donal , Fleming Mary , Daly Eimear , Gaughan Natasha , Zabetakis Ioannis , Traas Con , Tsoupras Alexandros
Published: August 2021

Alcoholic beverages like apple cider are considered functional beverages with several health benefits, when consumed in moderation, which are mainly attributed to their microbiota and the plethora of their bioactive compounds. Among them, bio-functional polar lipids (PL) have recently been found in apple cider, which despite low quantities, have exhibited strong anti-inflammatory and anti-platelet properties, while fermentation seems to affect the functionality of apple cider’s PL bioactives. The aim of the present study was to elaborate yeast strains isolated from the complex mixtures of apple surface and must yeasts for evaluating their effects on the anti-platelet functional properties of PL bioactives from their final fermented apple cider products. First, bio-functional PL were extracted and separated from the biomass of the different isolated apple surface/must yeast strains, and were further assessed for their anti-platelet potency against human platelet aggregation induced by the potent inflammatory and thrombotic mediator platelet-activating factor (PAF), or by a classic platelet agonist like adenosine diphopshate (ADP). Novel functional apple ciders were then produced from the fermentation of apple juice by elaborating the most bioactive and resilient yeast strains isolated from the apple must with optimum fermentation properties. PL bioactives extracted from these novel apple cider products were also further assessed for their anti-platelet properties against both the PAF and ADP pathways of human platelet aggregation. These novel cider products were found to contain PL bioactives with lower IC50 values (~40 μg) and thus increased anti-platelet potency against platelet aggregation induced by PAF and ADP. GC-MS analysis of the PL bioactives extracted from these novel apple ciders showed that apple cider PL bioactives are rich in monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA), such as the omega-6 linoleic acid (LA) and the omega-3 alpha linolenic acid (ALA), with favorably lower levels for their omega-6/omega-3 PUFA ratio, which further support the observed strong anti-platelet properties putative anti-inflammatory potency for the apple cider PL bioactives. However, further studies are needed in order to elucidate and fully characterize the apple yeast strains that can be utilized for increasing the anti-inflammatory, anti-platelet and cardioprotective functional properties of their fermented apple cider products.
Depletion of Psoas Muscle Mass after Systemic Chemotherapy Is Associated with Poor Prognosis in Patients with Unresectable Pancreatic Cancer
Authors: Iwai Naoto , Okuda Takashi , Oka Kohei , Sakagami Junichi , Harada Taishi , Ohara Tomoya , Hattori Chie , Taniguchi Masashi , Sakai Hiroaki , Hara Tasuku , Tsuji Toshifumi , Komaki Toshiyuki , Kagawa Keizo , Dohi Osamu , Yasuda Hiroaki , Itoh Yoshito
Published: August 2021

The impact of the psoas muscle mass index (PMI) on survival is still poorly understood in unresectable pancreatic cancer. Thus, we aimed to investigate whether the PMI at diagnosis or its decrease during chemotherapy can influence the prognosis of unresectable pancreatic cancer. The data of 100 patients were analyzed, and they were divided into two groups according to the median PMI in each sex. Subsequently, 72 patients undergoing computed tomography (CT) within 30–100 days from CT at diagnosis were evaluated in terms of PMI change rate, and divided into two groups based on the median. We evaluated the clinical characteristics and outcomes in terms of the PMI at diagnosis or its decrease during chemotherapy. The median PMI was 5.00 in males, and 3.66 in females. The median overall survival (OS) was 278.0 days in the high-PMI group and 221.0 days in the low-PMI group (p = 0.329). The median PMI change rate was −2.4%. The median OS was 347.0 days in the group without PMI decrease and 172.0 days in the group with PMI decrease (p = 0.001). We determined that a pivotal prognostic factor was not the PMI at diagnosis, but rather PMI decrease during chemotherapy in unresectable pancreatic cancer.
The Role of Natural Killer Cells in Soft Tissue Sarcoma: Prospects for Immunotherapy
Authors: Fortes-Andrade Tânia , Almeida Jani Sofia , Sousa Luana Madalena , Santos-Rosa Manuel , Freitas-Tavares Paulo , Casanova José Manuel , Rodrigues-Santos Paulo
Published: August 2021

Soft-tissue sarcomas (STS) represent about 80% of sarcomas, and are a heterogeneous group of rare and malignant tumors. STS arise from mesenchymal tissues and can grow into structures such as adipose tissue, muscles, nervous tissue and blood vessels. Morphological evaluation has been the standard model for the diagnosis of sarcomas, and even in samples with similar characteristics, they present a diversity in cytogenetic and genetic sequence alterations, which further increases the diversity of sarcomas. This variety is one of the main challenges for the classification and understanding of STS patterns, as well as for their respective treatments, which further decreases patient survival (<5 years). Despite some studies, little is known about the immunological profile of STS. As for the immunological profile of STS in relation to NK cells, there is also a shortage of studies. Observations made in solid tumors show that the infiltration of NK cells in tumors is associated with a good prognosis of the disease. Notwithstanding the scarcity of studies to characterize NK cells, their receptors, and ligands in STS, it is noteworthy that the progression of these malignancies is associated with altered NK phenotypes. Despite the scarcity of information on the function of NK cells, their phenotypes and their regulatory pathways in STS, the findings of this study support the additional need to explore NK cell-based immunotherapy in STS further. Some clinical trials, very tentatively, are already underway. STS clinical trials are still the basis for adoptive NK-cell and cytokine-based therapy.
Age and Cohort Trends of Malignant Melanoma in the United States
Authors: Lashway Stephanie G. , Harris Robin B. , Farland Leslie V. , O’Rourke Mary Kay , Dennis Leslie K.
Published: August 2021

The incidence of malignant melanoma in the United States is increasing, possibly due to changes in ultraviolet radiation (UVR) exposure due to lifestyle or increased awareness and diagnosis of melanoma. To determine if more recent birth cohorts experience higher rates of melanoma as they age, we examined age and birth cohort trends in the United States stratified by anatomic site and cancer type (in situ vs. malignant) of the melanoma diagnosed from 1975–2017. Poisson regression of cutaneous melanoma cases per population for 1975–2017 from the Surveillance, Epidemiology, and End Results (SEER) cancer registries was used to estimate age adjusted incidence for five-year birth cohorts restricted to Whites, ages 15–84. The rate of melanoma incidence across birth cohorts varies by anatomic site and sex. Melanomas at all anatomic sites continue to increase, except for head and neck melanomas in men. Much of the increase in malignant melanoma is driven by cases of thin (<1.5 mm) lesions. While increased skin exams may contribute to the increased incidence of in situ and thin melanoma observed across birth cohorts, the shifts in anatomic site of highest melanoma incidence across birth cohorts suggest changes in UVR exposure may also play a role.
Glutamatergic Signaling a Therapeutic Vulnerability in Melanoma
Authors: Eddy Kevinn , Chen Suzie
Published: August 2021

Like other cancers, melanomas are associated with the hyperactivation of two major cell signaling cascades, the MAPK and PI3K/AKT pathways. Both pathways are activated by numerous genes implicated in the development and progression of melanomas such as mutated BRAF, RAS, and NF1. Our lab was the first to identify yet another driver of melanoma, Metabotropic Glutamate Receptor 1 (protein: mGluR1, mouse gene: Grm1, human gene: GRM1), upstream of the MAPK and PI3K/AKT pathways. Binding of glutamate, the natural ligand of mGluR1, activates MAPK and PI3K/AKT pathways and sets in motion the deregulated cellular responses in cell growth, cell survival, and cell metastasis. In this review, we will assess the proposed modes of action that mediate the oncogenic properties of mGluR1 in melanoma and possible application of anti-glutamatergic signaling modulator(s) as therapeutic strategy for the treatment of melanomas.
Cancer-Testis Antigens in Triple-Negative Breast Cancer: Role and Potential Utility in Clinical Practice
Authors: Lam Runyi Adeline , Tien Tracy Zhijun , Joseph Craig Ryan , Lim Johnathan Xiande , Thike Aye Aye , Iqbal Jabed , Tan Puay Hoon , Yeong Joe Poh Sheng
Published: August 2021

Breast cancer cells commonly express tumour-associated antigens that can induce immune responses to eradicate the tumour. Triple-negative breast cancer (TNBC) is a form of breast cancer lacking the expression of hormone receptors and cerbB2 (HER2) and tends to be more aggressive and associated with poorer prognoses due to the limited treatment options. Characterisation of biomarkers or treatment targets is thus of great significance in revealing additional therapeutic options. Cancer-testis antigens (CTAs) are tumour-associated antigens that have garnered strong attention as potential clinical biomarkers in targeted immunotherapy due to their cancer-restricted expressions and robust immunogenicity. Previous clinical studies reported that CTAs correlated with negative hormonal status, advanced tumour behaviour and a poor prognosis in a variety of cancers. Various studies also demonstrated the oncogenic potential of CTAs in cell proliferation by inhibiting cell death and inducing metastasis. Multiple clinical trials are in progress to evaluate the role of CTAs as treatment targets in various cancers. CTAs hold great promise as potential treatment targets and biomarkers in cancer, and further research could be conducted on elucidating the mechanism of actions of CTAs in breast cancer or combination therapy with other immune modulators. In the current review, we summarise the current understandings of CTAs in TNBC, addressing the role and utility of CTAs in TNBC, as well as discussing the potential applications and advantage of incorporating CTAs in clinical practise.
Pathologic Characteristics of Pregnancy-Related Meningiomas
Authors: Giraldi Laura , Lauridsen Emma Kofoed , Maier Andrea Daniela , Hansen Jørgen Vinsløv , Broholm Helle , Fugleholm Kåre , Scheie David , Munch Tina Nørgaard
Published: August 2021

Meningiomas are the most common intracranial tumor. During pregnancy, explosive growth of a known meningioma occasionally occurs, but the underlying reasons remain unknown. Prolactin has been suggested as a possible key contributor to pregnancy-related meningioma growth. This study sets out to investigate prolactin and prolactin receptor status in 29 patients with pregnancy-related meningiomas in Denmark, from January 1972 to December 2016, as compared to 68 controls aged 20–45 years, also undergoing resection of a meningioma. Furthermore, we investigated potential differences in the progesterone and estrogen receptor statuses, WHO grade, Ki-67 labeling indices, and locations of the resected meningiomas between the cases and controls. Immunohistochemical analyses were performed, and histopathology and intracranial location were assessed with the investigator blinded for the case–control status. None of the samples stained positive for prolactin and very few samples stained positive for prolactin receptors, equally distributed among cases and controls. Estrogen and progesterone receptors generally followed the same distributional pattern between groups, whereas above cut-point Ki-67 labeling indices for both groups were observed. In conclusion, our results did not support the notion of prolactin as a key contributor to pregnancy-related meningioma growth. Rather, the similarities between the cases and controls suggest that meningiomas early in life may comprise a distinct biological entity.
‘I Didn’t Even Recognise Myself’: Survivors’ Experiences of Altered Appearance and Body Image Distress during and after Treatment for Head and Neck Cancer
Authors: Gibson Chandrika , O’Connor Moira , White Rohen , Jackson Melanie , Baxi Siddhartha , Halkett Georgia K. B.
Published: August 2021

Purpose: Preparation for head and neck cancer treatment is focused on practicalities of treatment. Little or no time is spent prior to treatment discussing aesthetic results of treatment or the psychosocial impact of living with an altered appearance after treatment. The objective of this study was to explore the experiences of survivors of head and neck cancers, with a focus on the psychosocial impact of altered appearance. Methods: A qualitative research approach based on social constructionist theory was used. Twenty-one semi-structured interviews were conducted with survivors of head and neck cancer who had been diagnosed in the previous six years. Thematic analysis was used to identify themes. Results: People diagnosed with HNC reported feeling rushed into treatment, with adequate procedural preparation but little or no preparation related to appearance. The main themes included: Preparation (sub-themes: Decision-making; and Preparation for Altered Appearance); Altered Appearance (sub-themes: Weight Loss; Face, Skin and Hair Changes; and Reconstructive Surgery); and Consequences (sub-themes Reactions from Others; Adapting to Altered Appearance). Conclusions: Body image distress related to altered appearance, contributed to psychosocial issues for many people diagnosed with head and neck cancer. Current practice provides information pre-treatment about many aspects of coping; however, the subject of appearance is not routinely addressed. Communication skills training for health professionals that improves their comfort and sensitivity in discussing and conveying compassion around issues of altered appearance, body image, and trauma, is needed to decrease suffering for survivors, support healthy adaptation to living with altered appearance, and increase their satisfaction with health care.