bluuebunny/crossref_metadata_2025 huggingface dataset:
Sodium-Glucose Co-Transporter 2 inhibitors and the Short-term Risk of Bladder Cancer: An International Multi-Site Cohort Study
Authors: Abrahami Devin , Tesfaye Helen , Yin Huimin , Vine Seanna , Hicks Blanaid , Yu Oriana H.Y. , Campeau Lysanne , Platt Robert W. , Schneeweiss Sebastian , Patorno Elisabetta , Azoulay Laurent
Published: September 2022

  

Objective: To determine whether sodium-glucose co-transporter 2 (SGLT2) inhibitors, compared with glucagon-like peptide-receptor agonists (GLP-1RAs) or dipeptidyl peptidase-4 (DPP4) inhibitors are associated with an increased risk of early bladder cancer events.

Research Design & Methods: We conducted a multi-site, population-based, new-user active comparator cohort study using the United Kingdom Clinical Practice Research Datalink, Medicare fee-for-service, Optum© Clinformatics® Data Mart, and MarketScan Health from January 2013 through December 2020. We assembled two cohorts of adults with type 2 diabetes initiating (1) SGLT2 inhibitors or GLP-1RAs, and (2) SGLT2 inhibitors or DPP4 inhibitors. Cox proportional hazards models were fit to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of incident bladder cancer. The models were weighted using propensity score fine stratification. Site-specific HRs were pooled using random-effects models.

Results: SGLT2 inhibitor (n=453,560) and GLP-1RA (n=375,997) users had a median follow-up ranging from 1.5-2.2 years. Overall, SGLT2 inhibitors were not associated with an increased risk of bladder cancer, compared with GLP-1RAs (HR=0.90; 95% CI: 0.81-1.00). Similarly, when compared with DPP-4 inhibitors (n=853,186), SGLT2 inhibitors (n=347,059) were not associated with an increased risk of bladder cancer (HR: 0.99, 95% CI: 0.91-1.09) over a median follow-up ranging from 1.6-2.6 years. Results were consistent across sensitivity analyses.

Conclusions: Contrary to previous randomized controlled trials, these findings indicate that the use of SGLT2 inhibitors is not associated with an increased risk of bladder cancer when compared with GLP-1RAs or DPP4 inhibitors. This should provide reassurance on the short-term effects of SGLT2 inhibitors on bladder cancer incidence.
Longitudinal association of DNA methylation with type 2 diabetes and glycemic traits: A 5-year cross-lagged twin study
Authors: Hong Xuanming , Wu Zhiyu , Cao Weihua , Lv Jun , Yu Canqing , Huang Tao , Sun Dianjianyi , Liao Chunxiao , Pang Yuanjie , Pang Zengchang , Cong Liming , Wang Hua , Wu Xianping , Liu Yu , Gao Wenjing , Li Liming
Published: September 2022

Previous cross-sectional Epigenome-Wide Association Studies (EWASs) in adults have reported hundreds of 5′-cytosine-phosphate-guanine-3′ (CpG) sites associated with type 2 diabetes mellitus (T2DM) and glycemic traits. However, the results from EWASs have been inconsistent, and longitudinal observations of these associations are scarce. Furthermore, few studies have investigated whether DNAm could be modified by smoking, drinking and glycemic traits, which have broad impacts on genome-wide DNAm, and results in altering the risk of T2DM. Twin studies provide a valuable tool for epigenetic studies, as they are naturally matched for genetic information. In this study, we conducted a systematic literature search in PubMed and EMBASE for EWASs, and 214, 33, and 117 candidate CpG sites were selected for T2DM, HbA1c and fasting blood glucose (FBG). Based on 1,070 twins from the Chinese National Twin Registry, 67, 17 and 16 CpG sites from previous studies were validated for T2DM, HbA1c and FBG. Longitudinal review and blood sampling for phenotypic information and DNAm were conducted twice in 2013 and 2018 on 308 twins. A cross-lagged analysis was performed to examine the temporal relationship between DNAm and T2DM or glycemic traits in the longitudinal data. 11 significant paths from T2DM to subsequent DNAm and 15 paths from DNAm to subsequent T2DM were detected, suggesting both directions of associations. For glycemic traits, we detected 17 cross-lagged associations from baseline glycemic traits to subsequent DNAm, and none was from the other cross-lagged direction, indicating CpG sites may be the consequences, not the causes, of glycemic traits. Finally, a longitudinal mediation analysis was performed to explore the mediation effects of DNAm on the associations of smoking, drinking and glycemic traits with T2DM. No significant mediations of DNAm in the associations linking smoking and drinking with T2DM were found. In contrast, our study suggested the potential role of DNAm of cg19693031, cg00574958 and cg04816311 in mediating the effect of altered glycemic traits on T2DM.
A Pilot Study: The Effectiveness of Augmenting Alveolar Bone Defects with Bone Marrow Aspirate Impregnated Allogeneic Graft
Authors: C Calhoun Colonya
Published: September 2022

Purpose: The purpose of this pilot study was to evaluate the effectiveness of bone marrow aspirate impregnated allogeneic graft as compared with autogenous bone grafting in inducing adequate bone for endosseous dental implants. Materials and Methods: Sixteen patients with alveolar bone defects secondary to trauma, pathology or infection were augmented with bone marrow aspirate impregnated allogeneic bone. Bone induction was assessed by alveolar ridge height and width using cone beam CT obtained before and 4 months after treatment as compared to published controls using autogenous harvesting sites. Results: Mean increases in alveolar ridge height at 4 months after treatment were similar to established controls using traditional autogenous harvesting sites: 3.9 mm and 3.8 respectively. Mean increases in alveolar ridge width (buccal to lingual) at the crest of the ridge were similar between both autogenous, allogeneic and bone marrow aspirate groups: 4.33, 4.56 and 3.97 respectively. Seven of the 10 patients have received dental implants which have remained osseointegrated at least 1 year post-implantation. In addition, subject undergoing BMA harvest had VAS scores of one 1 week after harvest as compared to a VAS of 5.5 in published controls using traditional anterior iliac bone harvest. Also only 9% of subjects reported any pain 1 week after BMA harvest versus 15% and 70% in published controls using the proximal tibia as a harvest site. Conclusion: This study is the first pilot study using BMA impregnated allogeneic bone to augment alveolar bone defects as an adequate source of bone for functional loading of endosseous dental implants as compared to more traditional forms of grafting
La gamificación como estrategia de evaluación bajo el enfoque flipped learning
Authors: Morales Salas Rubí Estela
Published: September 2022

El flipped learning como metodología activa en la educación se ha convertido en una de las más usadas por los docentes de todo el mundo. Consiste en un enfoque integral de procesos y estrategias didácticas centradas en mejorar la experiencia de aprendizaje de los estudiantes y aumentar su compromiso e implicación en su propio proceso. Se presenta una experiencia educativa de un curso de estudiantes de posgrado desarrollada durante el primer semestre del 2021 cuyo objetivo fue identificar el nivel de satisfacción respecto a la implementación de la gamificación como estrategia de evaluación bajo el enfoque de flipped learning. Se sitúo como una investigación exploratoria, descriptiva-transversal, con un enfoque mixto y un muestreo no probabilístico por conveniencia. Se aplicó una encuesta mediante un cuestionario que consistió en una serie de preguntas. Los resultados muestran que la intervención fomentó la participación y proactividad de los estudiantes, por lo tanto, impulsó el aprendizaje y permitió aprovechar eficientemente el tiempo en el aula.
PERDAS POR IMPAIRMENT DO GOODWILL – ANÁLISE DOS FATORES QUE DETERMINAM O SEU RECONHECIMENTO
Authors: Thiago Leonardo Esteves , Silva Fabiana Lopes da , Grecco Marta Cristina Pelucio , Silva Júnior Luís Carlos Gomes da , Leão Cícero Pereira
Published: September 2022

O objetivo deste artigo é apresentar uma análise sobre quais fatores podem influenciar o reconhecimento de perdas por impairment do goodwill, considerando uma amostra de 46 companhias brasileiras no período de 2010 a 2016. Os dados foram tratados e analisados com a utilização da regressão múltipla com dados em painel. O resultado ilustrou que as variáveis relevantes para tal objetivo foram o plano de bonificação baseado em opções, a mudança de gestão e o valor do goodwill.
ANÁLISE DE SENSIBILIDADE DAS PREMISSAS ATUARIAIS DOS PLANOS PREVIDENCIÁRIOS: IMPACTO POTENCIAL NAS DEMONSTRAÇÕES CONTÁBEIS DAS COMPANHIAS BRASILEIRAS LISTADAS NO IBOVESPA
Authors: Lopes da Silva Fabiana
Published: September 2022

O objetivo do estudo foi avaliar o possível impacto na obrigação atuarial das companhias brasileiras listadas no IBOVESPA patrocinadoras de planos de benefícios, decorrente da análise de sensibilidade das premissas atuariais. Foram analisadas 24 empresas que apresentaram informações em Notas Explicativas sobre planos de benefícios pós-emprego, na modalidade de benefício definido (BD) e/ou plano de saúde pós-emprego, no exercício social de 2018. Com base nas análises efetuadas à luz do Pronunciamento Técnico CPC 33 (R1), verificou-se que as premissas significativas mais utilizadas na análise de sensibilidade foram: taxa de desconto (95,83%), custos médicos (54,17%), tábua de mortalidade (41,67%), crescimento salarial (29,17%) e reajuste de benefícios (8,33%). Com base nos valores informados na análise de sensibilidade, foram calculados os possíveis impactos da alteração de premissas no valor presente da obrigação atuarial das empresas. Considerando o efeito da taxa de juros no cálculo da obrigação atuarial do plano de benefício, verificou-se no cenário de aumento da obrigação atuarial o percentual médio de 8,50%. Já no cenário de redução da obrigação, a estimativa média seria de 6,31%.
A RELAÇÃO DOS RECURSOS DE GREEN BONDS (TÍTULOS VERDES) NO ENDIVIDAMENTO DAS EMPRESAS BRASILEIRAS
Authors: Mantovani Flavio Roberto , Cassajus Bruna , Takaasi Gustavo
Published: September 2022

A presente pesquisa apresenta a relação dos títulos verdes com o nível de endividamento das empresas brasileiras responsáveis pelas maiores emissões destes títulos. Para alcançar esse objetivo, utilizou-se de seis empresas emissoras de títulos verdes, sendo estas, as três maiores emissoras deste título em moeda nacional e as outras três em moeda estrangeira, até o ano de 2018. A pesquisa é descritiva e os dados foram coletados por meio do relatório anual da FEBRABAN e das demonstrações financeiras das empresas objeto de estudo. Esses dados coletados foram processados em duas etapas, a primeira calculando a razão entre o capital de terceiros sobre o capital de terceiros somado ao patrimônio líquido e a segunda calculando o valor dos títulos verdes sobre o capital de terceiros, o resultado obtido após o processamento dos dados é de que o endividamento das empresas objeto de pesquisa cresceu ao decorrer dos anos e que a representatividade dos títulos verdes sobre o total da dívida com terceiros é baixa.
A AUDITORIA TRIBUTÁRIA COMO INSTRUMENTO DE APOIO À GESTÃO
Authors: Stuque Lilian da Silva Ribeiro , Pereira de Carvalho Francisco José , Lopes Juliano de Jesus , Da Silva Carlos Eduardo , Gimenez Levi
Published: September 2022

A proposta inserida na presente pesquisa foi a de apresentar a Auditoria Tributária como ferramenta de apoio aos gestores da empresa e em especial aos responsáveis pelos aspectos contábeis e tributários da empresa. Os estudos revelaram que mesmo os profissionais experientes e que também atuam na academia possuem interpretações diferentes sobre os textos legais que compõem a legislação tributaria e que, em algumas vezes apresentam eventualmente dificuldades de entendimento ou informações não muito claras e com aparentes divergências entre os parágrafos e artigos de uma mesma lei ou de uma carta consulta. O trabalho evidencia isso quando aborda duas questões apresentadas em recentes exames de suficiência do CFCConselho Federal de Contabilidade para as quais cabem interpretações divergentes. A Metodologia aplicada foi composta, além das consultas bibliográficas, foram simultaneamente as pesquisas quantitativas em razão dos valores coletados e dos cálculos realizados; bem como a qualitativa quanto a realização de analises e interpretações sobre textos legais, comparandoos com a realidade vivenciada nos Exames de Suficiência do CFC – Conselho Federal de Contabilidade e no comportamento das respectivas Bancas Examinadores no enfrentamento dos recursos interpostos pelos candidatos para a eliminação de questões.
PRINCIPAIS HABILIDADES PARA O DESENVOLVIMENTO PROFISSIONAL NO BRASIL: UMA ANÁLISE SOB A ÓTICA DOS ATUÁRIOS
Authors: Baltazar Leonardo , Carvalho da Silva Laura , Lumertz José Antônio , Junges da Silva Fernanda Beatriz
Published: September 2022

O objetivo desta pesquisa foi identificar quais habilidades são consideradas mais importantes para o desenvolvimento do profissional de atuário no Brasil, tendo em vista sua importância para o setor econômico-financeiro, sua base de conhecimentos multidisciplinar e o pouco esclarecimento da sociedade sobre esta profissão. Assim, realizou-se uma pesquisa de levantamento direcionado aos profissionais da área atuarial no Brasil. As habilidades analisadas foram classificadas em comportamentais, analíticas, técnicas em sistemas, técnicas, raciocínio lógico, habilidade textual ou idioma e experiência técnica. A análise dos dados considerou informações como faixa etária, sexo, formação acadêmica, região de formação e faixa salarial. Como resultados, obteve-se que as habilidades comportamentais são consideradas as mais importantes, na perspectiva dos atuários, para o seu desenvolvimento profissional.
MÉTODO DE CÁLCULO DE REAJUSTE POR VARIAÇÃO DE CUSTOS PARA CONTRATOS DE PLANOS DE SAÚDE SUPLEMENTAR A PARTIR DA TEORIA DA CREDIBILIDADE
Authors: Marques de Oliveira Dias Monize , Baltazar Leonardo , Lumertz José Antônio
Published: September 2022

A estimação do percentual de reajuste por variação de custos em contratos de planos de saúde ainda é um processo subjetivo no meio atuarial. A análise do índice de sinistralidade, normalmente utilizada como ferramenta nesse processo, pode resultar em um reajuste viesado, dada a assimetria na distribuição probabilística dos dados de custo assistencial desse setor. Dessa forma, este estudo objetivou desenvolver um método de cálculo para o percentual de reajuste a partir da Teoria de Credibilidade. Para isso, foram utilizados dados de uma operadora de saúde de grande porte. Concluiu-se que a sinistralidade média por contrato seria de 73%, que é menor do que a sinistralidade observada, permitindo inferir que o método proposto se demonstrou adequado, pois, além de ser coerente, apresentando embasamento estatístico e atuarial, possibilitou um cálculo satisfatório do reajuste, contribuindo tanto para a comunidade acadêmica, quanto para o setor de saúde suplementar, considerando que este estudo pode ser base para o cálculo do reajuste que as operadoras aplicam em seus contratos. Como limitações, o estudo utilizou uma base de dados históricos referente a 12 meses, o que pode impactar na eficiência do modelo estatístico de predição em virtude dos cenários de alta variabilidade e imprevisibilidade.
princípio da dignidade da pessoa humana como fundamento do reconhecimento da identidade sexual como direito de personalidade: análise da ADPF 527
Authors: Esmanhotto Maria Victória da Fonseca , Lins Rafael Santana Barros , Gunther Luiz Eduardo
Published: September 2022

O objetivo do presente trabalho foi analisar o princípio da dignidade humana se materializar por meio dos direitos de personalidade aplicados à possibilidade de escolha da pessoa transexual em optar pelo encarceramento na facilidade prisional do gênero que lhe proporcionar maior segurança a integridade física e psicológica. Para tanto, utilizou-se o método teórico-bibliográfico, analisando doutrina constante em livros, artigos e publicações jurídicas, bem como o estudo jurisprudencial. Foram visitados também os textos legais que versam sobre o tema. Ao final, concluiu-se que o Estado deve assegurar condições mínimas de garantia à preservação dos direitos de personalidade às pessoas transexuais.
Acordo de Não Persecução Penal e sua aplicação no tempo aos casos anteriores a sua vigência
Authors: Bomfim Luciano Sérgio Ventin , Melo Robson Silva , Alves Jaiza Sâmmara de Araujo
Published: September 2022

O Acordo de não Persecução Penal (ANPP) é o mais novo instituto de justiça penal negociada a ser entabulado entre Ministério Público e indiciado. O ANPP é um mecanismo de promoção de política criminal desencarceradora, uma vez que sua aplicação se estende à maioria dos crimes previstos no Código Penal e legislação extravagante, trazendo como punição o cumprimento de obrigações diversas da privação de liberdade. Todavia, a sua aplicação ainda não é uniforme, pois a doutrina, assim como os tribunais superiores, ainda não pacificou a questão da retroatividade do acordo, por se tratar de lei processual mista com caráter mais benéfico aos acusados/réus. O objetivo do presente artigo é traçar um panorama geral sobre o instituto do ANPP estabelecendo conceituando os seguintes pontos: constitucionalidade, natureza jurídica, aplicação no tempo e a partir das premissas estabelecidas firmar os limites de alcance da referida norma, assim como conferir-lhe a interpretação mais justa e adequada tendo como parâmetro o sistema acusatório e as normas constitucionais que regem a matéria. A metodologia adotada é pesquisa bibliográfica, utilizando como método de estudo o hipotético logico-dedutivo. Nesse diapasão, o Acordo de Não Persecução Penal é entendido como um direito subjetivo do réu, oriundo de uma norma mista, processual e penal, que trata de direitos materiais como a extinção da punibilidade, devendo, portanto, retroagir para alcançar todos os casos anteriores a sua vigência, ressalvado o trânsito em julgado, conforme disciplina a Constituição Federal de 1988 em seu art. 5º inciso XL.
Dalrymple e a importância do preconceito
Authors: Salatini Rafael
Published: September 2022

O livro Em defesa do preconceito, escrito por Theodore Dalrymple, um dos vários pseudônimos do psiquiatra e ensaísta britânico Anthony Daniels, apresenta diversos ensaios curtos defendendo uma visão axiologicamente positiva do tema do preconceito, representando uma vertente conservadora desse debate.
Canibalismo social
Authors: Gonçalves Rodrigo Portão Puzine , Cenci Daniel Rubens , Steffler Hellin Thaís
Published: September 2022

O presente artigo busca analisar a questão da fome de dignidade no Brasil a partir de uma análise do controle social através da economia, bem como do discurso capitalista e neoliberalista sobre o desenvolvimento econômico. O problema que orienta a pesquisa pode ser sintetizado na seguinte pergunta: Em que medida o desenvolvimento econômico seguindo as teorias liberais ou neoliberais afeta a população mais pobre? Com base nos dados levantados a partir de um conjunto de pesquisas realizadas sobre o tema nas áreas do Direito, Antropologia e Sociologia, refletidas a partir da bibliografia que dá sustentação ao presente estudo, torna-se possível afirmar que o atual modelo de desenvolvimento fomenta a pobreza, desigualdade, elimina direitos e a própria dignidade. O objetivo geral do texto consiste em avaliar como o desenvolvimento econômico neoliberal acaba por ser alimentado pela miséria da população. Os objetivos específicos do texto, que se refletem na sua estrutura em três seções, são: a) Avaliar, a partir de estudos já realizados no âmbito do Direito, Antropologia e Sociologia o atual estado do desenvolvimento econômico escolhido e implementado no Brasil; b) Esclarecer como esse desenvolvimento amplia desigualdades; c) Explicitar a incongruência de tal modelo. O método de pesquisa empregado foi o hipotético-dedutivo, mediante o emprego de técnica de pesquisa bibliográfica e documental.
Akım Modlu Logaritmik Tabanlı AB Sınıfı Dördüncü Derece Chebyshev Alçak Geçiren Süzgeç Tasarımı
Authors: KIRÇAY Ali , KÖROĞLU Derya Barış
Published: September 2022

Bu çalışmada akım modlu durum uzay sentez metodu kullanılarak, dördüncü derece fark alıcı AB sınıfı logaritmik ortam Chebyshev alçak geçiren filtre tasarlanmıştır. Önerilen filtrenin kesim frekansı 50Mhzdir. Tasarımda sadece npn tipi transistör , topraklı kapasitör ve 2.5 V besleme kaynağı kullanılarak çalışılmıştır. Süzgeç parametreleri kolayca değiştirilerek kesim frekansı ayarlanabilmektedir. Bu ayarlama akım değeri değiştirilerek yapılmaktadır. Literatürde bulunan Chebyshev süzgeçlere göre yüksek frekanslarda çalışıyor olması en büyük üstünlükleri arasında yer almaktadır. Teorik analiz sonuçları SPICE yardımıyla doğrulanmıştır. Tasarlanan filtre için ideal BJT ve AT&T CBIC-U2 tip transistör kullanılmıştır.
Farklı Su/Bağlayıcı Oranına Sahip Betonlarda Nano Silika ve Granüle Yüksek Fırın Cürufu Kullanımın Mekanik ve Elastik Özellikler Üzerine Etkisi
Authors: TÜRKMENOĞLU Hasan Nuri , ÖNDER Esen , ATAHAN Hakan Nuri
Published: September 2022

Yapılan çalışmada, farklı su/bağlayıcı oranına sahip üç farklı beton karışımına, ağırlıkça %1 oranında nano silika (NS) ve/veya ağırlıkça %20 oranında granüle yüksek fırın cürufu (GYFC) eklenmesi ile birlikte basınç dayanımı, elastisite modülü ve Poisson oranı değerlerinde meydana gelen değişimler ve mineral katkıların, farklı su/bağlayıcı oranlarına sahip beton karışımlarının özellikleri üzerindeki etkinlikleri araştırılmıştır. Elde edilen sonuçlar incelendiğinde, su/bağlayıcı oranı 0,68 olan beton grubunda NS ve/veya GYFC kullanımının beton özelliklerine olumlu bir etkisinin olmadığı görülmüştür. Fakat su/bağlayıcı oranının azalması ile birlikte, mineral katkı kullanımı hem basınç dayanımı hem de elastisite modülü değerleri üzerinde belirgin iyileştirmeler sağlamıştır. Bu etki, özellikle NS ve GYFC’nin birlikte kullanıldığı karışımlarda en yüksek seviyeye ulaşmıştır. Örneğin, 0,53 su/bağlayıcı oranına sahip betonlarda sadece NS veya sadece GYFC kullanımı ile referans karışıma göre basınç dayanımında elde edilen artış oranları sırasıyla %8,8 ve %7,8 iken, NS ve GYFC’nin birlikte kullanılmasıyla artış oranı %15,1 olarak elde edilmiştir. Bunlara ek olarak, Poisson oranı değerlerinin referans betonlarda su/bağlayıcı oranının azalması veya karışımda GYFC kullanılması ile birlikte azaldığı fakat karışıma NS eklenmesi ile birlikte arttığı belirlenmiştir. Bunlara ek olarak, su/bağlayıcı oranının azalmasıyla ve özellikle NS kullanımı ile birlikte, betonun davranışı belirgin bir şekilde lineer-elastik davranışa yakınlaşmıştır.
Oseanografi dalam Perspektif Al-Qur`an
Authors: Hasani Z Jufri
Published: September 2022

Tulisan ini mencoba mengungkap mukjizat Al-Qur`an di bidang kelautan. Laut memiliki sumber daya alam yang melimpah, Allah telah menciptakan laut yang begitu luas, selain tempat berdiamnya ikan dan binatang laut lainnya, di laut juga tersimpan mutiara indah dan bernilai tinggi, energi laut yang sangat bermanfaat bagi manusia. Selain sumber kekayaan alam yang melimpah, di laut juga tersimpan energi yang bisa mendatangkan kerusakan bagi kehidupan manusia. Al-Qur`an memberikan informasi yang cukup kepada manusia tentang laut sehingga informasi-informasi Al-Qur`an tersebut menjadi dasar bagi manusia untuk mengembangkan ilmu dan teknologi kelautan sehingga ayat-ayat Al-Qur`an tentang laut semakin terungkap dan manfaat laut yang begitu banyak bisa diambil untuk kepentingan manusia. Penelitian ini menggunakan metode penelitian tafsir tematik sederhana di mana  penulis mengumpulkan ayat-ayat tentang laut dan memilih beberapa ayat untuk ditafsirkan sesuai dengan tema dan sub pembahasan yang penulis susun sebelumnya. Ayat-ayat tersebut ditafsirkan dengan pendekatan sains dan teknologi untuk mendapatkan informasi secukupnya tentang pesan-pesan Al-Qur`an terkait laut.
Pemikiran Sayyid Quthb tentang Makna Qital dalam Kitab Tafsir Fi Zhilal Al-Qur’an
Authors: Ismail Hidayatullah , Arni Jani , Arham Ihfasni , Hermanto Edi
Published: September 2022

Tulisan ini merupakan kajian tafsir tematik dengan fokus pembahasan seputar makna ayat-ayat perang (qital) dalam Al-Qur’an perspektif Sayyid Quthb. Secara umum qital dalam Al-Qur’an dimaknai oleh sebagian mufassir dengan perang melawan kelompok kâfirîn yang menyerang terlebih dahulu, atau dengan kata lain bersifat defensif (dhifâ’iyah) dan melarang perang yang bersifat menyerang atau ofensif (thalabah). Berbeda Sayyid Quthb yang kental dengan basic pergerakan (haraki), bahwa qital dalam Al-Qur’an tidak hanya bermakna defensif, namun juga ofensif, dan itu bukan merupakan sebagai bentuk ekstremisme dan radikalisme, sebab Islam memiliki batasan dan kode etik dalam berperang, sehingga perang menjadi tidak serampangan. Selain itu tujuan utamanya adalah menegakkan kalimat Allah dan melepaskan manusia dari penghambaan kepada selain Allah.
Reaktualisasi Moderasi Islam Terhadap Problematika Syariah Pada Era 4.0
Authors: Novendri S Mochammad , Ismail Hidayatullah , Yahya Maali Dasman
Published: September 2022

Artikel ini membahas tentang reaktualisasi moderasi Islam terhadap problematika syariah pada era 4.0. Problematika syariah adalah permasalahan yang tiap hari berada dilingkungan kaum muslimin , baik berupa muamalah maupun ibadah. Maka penelitian bertujuan untuk memberikan gambaran mengenai moderasi islam terhadap problematika syariah pada era 4.0. Penelitian ini merupakan penelitian pustaka. Metode pengumpulan data pada penelitian ini meliputi buku-buku dari data primer dan data sekunder, serta sumber lainnya. Metode analisis dalam penelitian ini dengan menggunakan pendekatan konten analisis. Adapun hasil penelitian dapat disimpulkan bahwa moderasi Islam perspektif syari’ah dapat dikelompokkan dalam bentuk tiga aspek diantaranya dengan meringakan beban (taklil al-taklif), mempermudah urusan (‘adam al-harj) dan pelaksanaan hukum dengan bertahap (al-tadarraj al-tasyri’). Reaktulisasi moderasi Islam di era 4.0 adalah sebagai perwujudan dari implementasi konsep moderasi Islam berbasis syariah dalam mengikuti kemajuan zaman, dengan memperhatikan aspek prinsip dan dasar dalam memahami agama Islam.
Ayat Mutasyabihat Tentang Keberadaan Allah Perspektif Para Ulama
Authors: Susanti Riska
Published: September 2022

Dalam Islam rukun iman pertama ialah iman kepada Allah SWT, Bila seorang selaku muslim tidak meyakini adanya Allah SWT, sungguh orang tersebut berada didalam kesesatan yang nyata. Di antara ayat-ayat  mutasyabihat  adalah  ayat  yang  berbicara  tentang  zat  Allah SWT, seperti ayat tentang tangan, mata, wajah, istawa', dan sebagainya. Dalam jurnal ini ditulis Secara spesifik, mencoba  untuk  memaparkan  dan  mengulas  Ayat Mutasyabihat Tentang Keberadaan Allah Prespektif Para Ulama, pada kitab tafsir yang digunakan  oleh  para  mufasir  dalam  memahami  ayat-ayat  Istiwa’, guna mempelajari ayat terkait keberadaan Allah SWT yaitu tinjauan ulang QS Thaha ayat 5, tentang ayat mutasyabihat yang ada di dalam Al-Qur’ an yang mengatakan jika Allah SWT itu bersemayam di atas Arsy. Peneliti merujuk kepada komentar yang ditulis oleh sebagian para ulama. Dalam hal ini komentar ulama-ulama yakni mengembalikan arti tersebut kepada Allah SWT. dan mayoritas mufasir tidak memahami istawa’ secara literal. Mereka tidak meyakini bahwa maksud istiwa’ adalah Allah duduk atau menetap di ‘Arsy. Mereka memalingkan makna istawa’ dari makna literalnya kepada makna lain yang sesuai dengan sifat-sifat keagungan yang dimiliki- Nya. Jurnal ini merupakan library research, yakni riset kepustakaan. Data-datanya didapat yang bersumber pada buku-buku serta jurnal yang berkaitan dengan permasalahan ini, paling utama kitab tafsir sebagian ulama, yaitu: tafsir Al-Qur’an al- Adzim karya Imam Ibnu Katsir, tafsir al- Munir karya Wahbah Al- Zuhaili. Jurnal ini memakai metode pengelolaan serta seterusnya mengumpulkan informasi dan membuat kesimpulan.
The Ethanol Extract of Tangse Liberica Coffee (Coffea liberica) Inhibited the Reduction of Leydig Cell Number and Testosterone Levels in Male Wistar Rats (Rattus norvegicus) Exposed to Ultraviolet B Light
Authors: Frisilla Dhea , Pangkahila Wimpie , Darwinata Agus Eka
Published: September 2022

Background: Aging is a complex mechanism related to various factors including free radicals. Free radicals that occur due to exposure to ultraviolet light can cause oxidative stress and damage the spermatogenesis process, including Leydig cells and testosterone. Therefore, antioxidants play a very important role in inhibiting these reactions, which are abundant in coffee. This study aimed to analyze the effect of the ethanol extract of Tangse liberica coffee (Coffea liberica) in inhibiting the decrease in Leydig cell number and testosterone levels in male Wistar (Rattus norvegicus) rats exposed to Ultraviolet B light.
Methods: This study includes a post-test-only control group type of laboratory experimental study. The research group was divided into three groups, namely positive control (without giving coffee), treatment 1 (giving coffee extract 216 mg/kgBW), and treatment 2 (giving coffee extract 432 mg/kg BW). A total of 30 rats were used in this study and exposed to UV-B 0.225 MW/cm² 8 hours per day for 28 days. Testosterone assessment was carried out by examining blood specimens and Leydig cell counts were carried out histologically with Hematoxylin-Eosin staining. One-way ANOVA analysis and Kruskal Wallis test followed by post hoc test were performed in this study with a significance level of 95%.
Results: The result showed a significant difference in the number of Leydig cells between the study groups (p = 0.016) with the highest mean in group 1, 48.27 9.12 cells/LFoV. The same thing also happened to the difference in testosterone levels between groups (p < 0.001) with the most dominant mean in treatment group 2 being 76.42 nmol/L.
Conclusion: The conclusion of this research is the administration of the ethanol extract of Tangse liberica coffee (Coffea liberica) can inhibit the decrease in Leydig cells number and testosterone levels in male Wistar (Rattus norvegicus) rats exposed to Ultraviolet B light.
The Impact of Ethical Leadership on Teacher’s Creativity in Public Universities of Democratic Republic of Congo (D.R.C): Mediating Role of Trust in Leader and Moderating Role of Advisor Support for Creativity
Authors: Glody Kapinga Beni , Meirong Zhen
Published: September 2022

This reseаrсh аims tо investigаte the imрасt оf ethiсаl leаdershiр оn teасher’s сreаtivity in рubliс universities оf Demосrаtiс Reрubliс оf Соngо (D.R.С) thrоugh mediаting rоle оf trust in leаder аnd the mоderаting rоle оf аdvisоr suрроrt fоr сreаtivity. Questiоnnаire wаs used аs the dаtа соlleсtiоn methоd. The number оf sаmрles is 225 school members оf different рubliс universities оf D.R.С. The results оf this study shоw thаt there is а роsitive relаtiоnshiр between ethiсаl leаdershiр аnd teacher’s сreаtivity; trust in leаder mediаtes the relаtiоnshiр between ethiсаl leаdershiр аnd teacher’s сreаtivity, аnd аdvisоr suрроrt fоr сreаtivity dоes nоt mоderаte the relаtiоnshiр between trust in leаder аnd teасher’s сreаtivity.
Monetary Policy Under Uncertainty: The Case of COVID-19 Health Crisis in Morocco
Authors: Najab Amal , Lajfari Kaltoum , Amrani Oumniya
Published: September 2022

The COVID-19 health crisis marked the beginning of a series of shocks that are a source of uncertainty that impacts the decision-making process of central banks around the world. The aim of this paper is to analyze the conduct of Morocco's monetary policy in a context of uncertainty, that of the COVID-19 health crisis. The results of our analysis have shown that in a context of uncertainty, the central bank is called upon to increase its communication to better guide the expectations of economic agents and ensure better transmission of the various monetary policy measures to the real economy. In addition, it must show itself to be credible by transmitting clear signals to restore the confidence of economic agents. However, central bank action alone is not enough. Conditions must be met, on the credit supply and credit demand sides, to remedy the structural imbalances that are holding back the competitiveness of our economy and to counter uncertainty.
Is Education a Tool for a Good Life? A Phenomenological Analysis of Views of University Students in Tanzania
Authors: Mpiluka Godfrey , Malenya Francis Likoye , Ndichu Francis Murira
Published: September 2022

Education is perceived to be one of the means through which people could achieve a good life. In this paper part of the data of the study that examined Tanzanian university students’ conceptions of a good life was used to assess students’ views on the extent to which education has promoted the attainment of a good life among Tanzanian citizens. It employed a qualitative research paradigm in which Interpretive Phenomenological Analysis (IPA)was used to analyse and interpret data from twenty-five (25) participants who consisted of twenty (20) third-year student teachers and five (5) lecturers of education from Dar es Salaam University College of Education. The findings indicated that education has promoted the attainment of a good life among Tanzanian citizens by eradicating and reducing poverty, creating employment opportunities, eradicating, and reducing some bad cultural practices, beliefs, misconceptions, and ignorance, promoting moral excellence, and adopting and deployment of science and technology. The study recommended that the government of Tanzania in collaboration with other educational stakeholders should continue investing in the provision of relevant and quality education to Tanzanians to promote the attainment of a good life among Tanzanian citizens.
Time Series Analysis and Forecast of COVID-19 Data in Southern African Countries
Authors: Sangaré Harouna , Fané Abdou
Published: September 2022

In this paper, we begin by analyzing different time series COVID-19 data by exploring confirmed, death and recovered daily reports from January 22, 2020 to September 2nd, 2021 in the southern African counties. We then use the Prophet model to forecast the total numbers of infected cases from September 3rd, 2021 to December 1st, 2021 by providing graphics and by giving tables containing the total numbers of infected cases from November 27, 2021 to December 1st, 2021 for each country in the zone.
Prolonged Opioid Use following Cervical Spine Fusion Surgeries-Incidence and Predictors of Use
Authors: Abolfotouh Sameh M. , Fogarty Casey , Matera Julia A. , Berry Abigale M. , Abolfotouh Mostafa A. , Choma Theodore J. , Goldstein Christina L.
Published: September 2022

Purpose: To determine the incidence and predictors of prolonged opioid use (OU) following cervical spine fusion surgery.

Methods: This is a retrospective cohort study of all patients who underwent cervical arthrodesis for degenerative cervical spine disease over 7 years, between 2010 and 2016, who had at least one year of postoperative follow up at the University of Missouri hospitals. Review of medical records was done to collect data on patient's characteristics, associated pain measures (pre/postoperative VAS), ASA score, and pre/postoperative OU. The predictors of prolonged OU at 3, 6 and 12 months following surgery were identified using the logistic regression analyses. Significance was considered at p<0.05.

Results: Incidences of postoperative OU were 50%, 42.5% and 30.2% at 3, 6 and 12 months respectively. After adjustment for all possible confounders, preoperative OU was a significant predictor of postoperative OU at 3 months (OR=3.06, 95% CI: 1.28-7.34, p=0.012), 6 months (OR=2.86, 95% CI: 1.01-8.14, p=0.049) and 12 months (OR=7.22, 95% CI: 2.76-18.90, p<0.001). Patients with cancer diagnosis were 23 times more likely to be prolonged opioid users for 12 months after surgery (OR= 23.13, 95% CI: 1.68-317.98, p=0.019).

Conclusion: Perioperative opioid prescription for patients with cervical spine fusion is quite common. Further prospective study is necessary to minimize the effect of confounding variables such as; disease severity, and postoperative functional status on the associations between pre-and postoperative opioid use. Minimizing preoperative opioid use should be investigated as a way to mitigate long–term opioid use.
Konsep Pendidikan Kepemimpinan Berbasis Tradisi: Telaah Etnopedagogi pada Tembang Tradisional Gundul-Gundul Pacul
Authors: Irsani Kholid , Aman Aman , Rochmat Saefur
Published: September 2022

Leadership education is one of the principles in the development of a nation. Various paradigms and theories of leadership have come from various backgrounds. This study focuses on examining the concept of tradition-based leadership education contained in the gundul-gundul pacul song. This study uses a qualitative research method with a literature approach to examine and integrate the concept of leadership contained in gundul-gundul pacul song with the concept of contemporary leadership education. This study found that song of gundul-gundul pacul has various concepts that are ideal to be applied in contemporary leadership ethnopedagogy because they have similarities in various factors such as communication, discipline knowledge, and problem solving.
Strategi Pengembangan Pembelajaran Sejarah Masa Pendudukan Jepang di Indonesia Berbasis Diorama Museum di Sekolah
Authors: Birsyada Muhammad Iqbal , Gularso Dhiniaty , Fairuzabadi Muhammad
Published: September 2022

Strategi serta upaya dalam mengajarkan sekaligus memahamkan materi sejarah pada pokok bahasan kependudukan Jepang yang diajarkan di kelas XI dengan Kompetensi Dasarnya adalah (1) menganalisis sifat pendudukan Jepang dan respon bangsa Indonesia, (2) menganalisis peran tokoh-tokoh nasional dan daerah dalam memperjuangkan kemerdekaan Indonesia. Pada tataran praksis masih banyak guru sejarah mengalami hambatan dalam setiap pembelajaran karena sulitnya menggambarkan lokasi serta visualisasi sejarah. Oleh sebab itu diperlukan sebuah strategi bagaimana mengajarkan peserta didik dalam memahami sejarah kependudukan Jepang. Penelitian ini bertujuan untuk mengungkap sekaligus menjelaskan bagaimana museum dapat menginformasikan tentang sejarah kependudukan Jepang sehingga dapat meningkatkan pemahaman peserta didik dalam tiap pembelajaran sejarah. Penelitian ini merupakan penelitian literatur yang dipadukan dengan sumber-sumber media dalam bentuk diorama museum. Melalui pemanfaatan sumber sejarah dapat dianalisis secara kritis, intepretatif sehingga menghasilkan historiografi untuk kepentingan pembelajaran sejarah. Hasil penelitian ini dapat dijelaskan bahwa dalam strategi pengembangan media pembelajaran, museum dapat dipakai sebagai salah satu sarana media pembelajaran sejarah yang interaktif. Diantara museum yang dapat dipakai adalah museum Benteng Vredeburg. Hal ini karena museum menawarkan berbagai sisi yang kompleks dan komperhernsif khusunya dalam hal visualisasi, intepretasi dan generasi dalam mengggambarkan sebuah peristiwa sejarah. Dengan demikian dalam pembelajaran sejarah materi pendudukan Jepang perlu adanya penguatan penggunaan media pembelajaran menggunakan museum.
Pengaruh Manajemen Laba Riil terhadap Audit Fee: Studi Empiris pada Perusahaan yang Terdaftar di Bursa Efek Indonesia Tahun 2015-2019
Authors: Arbi Panji Mustipa , Cheisviyanny Charoline , Septiari Dovi
Published: September 2022

This study aims to examine the effect of real earnings management (REM) on audit fees. This research was conducted on companies listed on the Indonesia Stock Exchange (IDX) in 2015-2019. The sample from this study was selected using purposive sampling technique that produces sample of 138 companies. The dependent variable of Audit fee is measured using the actual value of the audit fee divided by 100,000. REM as an independent variable is measured using Roychowdhury (2006) model which has been modified by Suksonghong and Amran (2020) which focuses on abnormal discretionary costs and abnormal production costs. The results of this study found that companies involved in REM activities carried out by client companies had a positive and significant effect on the audit fees paid to auditors.
Pengaruh Ukuran Perusahaan, Listing Age, Profitabilitas dan Reputasi KAP terhadap Corporate Internet Financial Reporting (CIFR) pada Bank Konvensioal Tahun 2018 - 2020
Authors: Hendasri Muhammad Raihan , Taqwa Salma
Published: September 2022

This study aims to determine the effect of firm size, Listing age, profitability and Reputation of audit firms on Corporate Financial Reporting (CIFR). The independent variables are company size, company age, profitability, audit firm reputation. While the dependent variable is CIFR. The sample used is Conventional Banks on the Indonesia Stock Exchange for the period 2018-2020. The statistical method used is multiple linear regression analysis. The results showed that firm size, profitability and reputation of the audit firm had no significant negative effect on CIFR, while firm age had a significant positive effect on CIFR.
Model Kolaborasi Pengembangan Geopark Bayah Dome
Authors: Fathahillah Mas Moch
Published: September 2022

A geopark is a geographical area that has a prominent geological heritage site and is part of a holistic concept of protection, education and sustainable development. Geoparks do not only include geological sites, but also have clear geographical boundaries and the synergy between the geological, biological, and cultural diversity that exists within the area. Communities living in the legacy play a role in protecting and enhancing the function of the natural heritage. The purpose of this research is to describe a collaboration model that is in accordance with the conditions in the development process of the Bayah Dome Geopark. This research is a descriptive research with a qualitative approach. Qualitative research was conducted because this research requires in-depth information with the aim of identifying the roles of collaborative actors in the development of the Bayah Dome Geopark. This study uses descriptive research in order to determine the Bayah Dome Geopark Development Collaborative Model which involves many stakeholders. The results of this study are that there are 8 collaborative processes that occur in the development of the boyah dome geopark, namely: (1) Network Structure, (2) Commitment To Common Purposes, (3) Trust Among Participants, (4) Governance, (5) Access To Authority, (6) Distributive Accountability, (7) Access To Resources, (8) Information Sharing.
Model Baru Pelayanan Administrasi Pemerintahan Daerah dalam Era New Normal di Indonesia
Authors: Lerrick Baskara Adyaksa
Published: September 2022

This study departs from a new habit adaptation movement that changes people's social interactions as a rational choice amid the threat of the Covid-19 outbreak. The purpose of this article is to empirically test that the current model of local government administration services in the island sub-district is very inefficient and less productive so that it has an impact on meeting the basic needs of the community comfortably and equitably. Furthermore, the study offers a new model for Duo-TM, namely Face and Machine Meeting. This article demonstrates the need for empirical studies in the development of local government administrative service models to trace the difficulties and geographical risks caused by the Covid-19 outbreak. This is especially relevant if the author refers to the reasons for massive changes in various social dimensions and forces the adaptation of new habits. On the other hand, the era of the industrial revolution 4.0 places the power of technology and information as a means of innovating services that are convenient, fast, cheap, and of high quality
MERANCANG PENELITIAN TINDAKAN KELAS (PTK) BAGI GURU DI SMA NEGERI 3 BUNGO
Authors: Despita Despita
Published: September 2022

In order to increase the graduate competency, SMA N 3 Bungo has been consistent to make the improvement during the learning process. Various attempts were made as sustainable development for teachers, administrators, and all elements of the school. As a professional educator, teachers are managed to get a competence development. To increase the ability of teachers in education, teachers are developed to doing research in learning process. The main purpose of this article is a reference to enhance the capabilities of teachers in conducting action research, so the methods of this study can be applied in SMA N 3 Bungo. This article discusses the various alternative teaching methods and strategies for classroom action research that can be applied by teachers.
PENINGKATAN AKTIFITAS DAN HASIL BELAJAR MENGGUNAKAN MEDIA KOMIK DAN QUIZ CREATOR PADA PELAJARAN TIK
Authors: Arman Arman
Published: September 2022

The study of information technologies have not run optimally because description of the lesson in the form is more theory than practice. From early observations that authors do look a lot of student who are less active during learning and concrentation when seen from the results of daily value activity, many students  not get  the KKM (Kriteria Ketuntasan Minimum) is 80 score. The problem  because teacher who prefer knowledge,  put students as objects  not as a subject, as well teachers less varying methods used, consequenltly increasing learning motivation of students does not occur. This type of research is a class  action research which to improve the learning results of activity and learners by utilizing the medium of comics and quiz creatior on the subjects of information and communication technologies (ICT) in  class IX.8 SMP Negeri 7 Padang as well as expected educators can employ the use of comics and  quiz creator in ICT learning. The goal of ICT learning achieved and can increase the activity of learners who have an impact on the results of the learning.
PENINGKATAN AKTIVITAS DAN HASIL BELAJAR MATEMATIKA SISWA DENGAN PENERAPAN PENDEKATAN INKUIRI TERBIMBING DI KELAS XII IPA3 SMA NEGERI 4 KOTA BENGKULU
Authors: Asiah Deny
Published: September 2022

This research aims to increase activity and mathematics student learning outcomes through inquiry learning approach. Places that are used in this study were SMA Negeri 4 Kota Bengkulu with research subjects are class XII IPA3  student, amounting to 32  students. This type of research is a descriptive qualitative research methods class action, which is implemented in two cycles, each cycle consisting of three meetings. The process of implementation of research include: the planning, implementation actions, monitoring and reflection. The results obtained in this study show that: 1) Average activity in cycle I (48.73%) increased by 14.92% in cycle II (63.65%), 2) Improved student learning outcomes of the cycle I to the second cycle of 28.57% from 57.14% to 85.71% cycle I to cycle II on the subject of mathematic. Based on these results, the suggestions can be submitted are: to improve the quality of teachers should be teaching mathematic in the inquiry learning approach. For researchers, in order to do further research on the effectiveness of learning by using the inquiry approach related to learning outcomes and learning processes, and are expected to contribute to the awakening of science and technology, especially learning mathematics.
JOYFUL LEARNING DALAM MENINGKATKAN KEMAMPUAN ANALISIS SISWA PADA MATA PELAJARAN AKUNTANSI
Authors: Cerya Efni
Published: September 2022

The main purpose of this study, researchers are as motivation for teachers in order to implement contextual learning approach and encourage students' interest because it uses a learning model that is attractive.  Accounting is indeed one of rich analysis and mathematical subject and delivers its own challenges. Nevertheles, creating a joyfull and quality learning is the responsibility of a teacher. The creativity of a teacher will be able to reduce the saturation and difficulty student in learning. Create joyfull learning is one of the alternatives that can be applied by teachers in achieving this. Interesting and effective process that it will be able to achieve learning objectives in the cognitive, affective and psychomotor.