bluuebunny/crossref_metadata_2025 huggingface dataset:
PENERAPAN METODE TAGUCHI UNTUK PERBAIKAN KUALITAS PENGEMASAN TEPUNG TAPIOKA DI PT. FLORINDO MAKMUR
Authors: Khoiri M Miftahul , Harahap Uun Novalia , Zaharuddin Zaharuddin
Published: July 2024

Peningkatan kualitas pada suatu produk merupakan  hal yang paling esensial bagi suatu perusahaan untuk tetap eksis dalam dunia bisnis dan sebagai faktor penting yang mempengaruhi tingkat perkembangan dan kemajuan perusahaan. Penelitian ini dilakukan untuk mengidentifikasi penyebab kecacatan pada proses pengemasan tepung tapioka di PT. Florindo makmur sehingga dapat mengurangi jumlah kerusakan dan memberikan usulan perbaikan pada kemasan tepung tapioka isi 500 gram. Data yang digunakan adalah data primer dan data sekunder dengan melakukan eksperimen menggunakan metode taguchi. Variabel terikat yang digunakan adalah perbaikan kualitas kemasan tepung tapioka berat 500 gram dengan variabel bebas yaitu kurangnya pekerja (SDM), kecepatan pengisian tepung dan Temperature heater.
Hasil penelitian menunjukkan bahwa kecepatan pengisian tepung sebagai faktor yang berpengaruh secara signifikan terhadap kualitas pengemasan tepung tapioka dengan persen kontribusi sebesar 67,3 % sehingga setting dan model pengaturan yang tepat untuk kemasan tepung tapioka agar di hasilkan kualitas kemasan yang sesuai spesifikasi adalah faktor sumber daya manusia 3 pekerja, faktor kecepatan pengisian tepung diperlambat menjadi 2,7 detik/pcs dan faktor Temperature Heater adalah 150 ℃.
ANALISIS MUTU PRODUK ROTI MAROS SANGGALEA GROUP MENGGUNAKAN METODE QUALITY FUNCTION DEPLOYMENT
Authors: Herdianzah Yan , Mubaraq Husni , Nusran Muhammad , Ahmad Arfandi , Safutra Nur Ihwan , Fole Asrul
Published: July 2024

Bread is a processed food made from wheat flour which is considered practical and filling. Roti Maros Sanggalea Group, Roti Maros Sanggalea Group is a trading business with processed products in the form of wet bread. The type of moist bread that is the flagship of Roti Maros Sanggalea Group is Maros bread. However, there has been a decline in demand for Maros bread over the past year. This decline can be seen in Maros bread production for the period January to March 2023. The decline in sales each month requires producers to develop their products well so they can always compete in the market. Therefore, this research aims to provide suggestions for attributes that consumers prioritize for Maros Sanggalea Group Roti products using the QFD (Quality Function Deployment)  method to improve the quality of Maros bakery products by identifying consumer needs and linking them to improvements in production techniques. The research results show that based on the priority level, the proposed improvement is by completing information about the product on the packaging, as well as adding a halal logo to the packaging, the price given to consumers must be in accordance with the quality of the product both in terms of ingredients and taste. Make the products being marketed easy for consumers to remember, for example uniquely designed packaging or distinctive flavors.
Comparison of simultaneous saccharification and fermentation with LPMO-supported hybrid hydrolysis and fermentation
Authors: Tang Chaojun , Cavka Adnan , Bui Mai , Jönsson Leif J.
Published: July 2024

Enzymatic saccharification is used to convert polysaccharides in lignocellulosic biomass to sugars which are then converted to ethanol or other bio-based fermentation products. The efficacy of commercial cellulase preparations can potentially increase if lytic polysaccharide monooxygenase (LPMO) is included. However, as LPMO requires both a reductant and an oxidant, such as molecular oxygen, a reevaluation of process configurations and conditions is warranted. Saccharification and fermentation of pretreated softwood was investigated in demonstration-scale experiments with 10 m3 bioreactors using an LPMO-containing cellulase preparation, a xylose-utilizing yeast, and either simultaneous saccharification and fermentation (SSF) or hybrid hydrolysis and fermentation (HHF) with a 24-hour or 48-hour initial phase and with 0.15 vvm aeration before addition of the yeast. The conditions used for HHF, especially with 48 h initial phase, resulted in better glucan conversion, but in poorer ethanol productivity and in poorer initial ethanol yield on consumed sugars than the SSF. In the SSF, hexose sugars such as glucose and mannose were consumed faster than xylose, but, in the end of the fermentation >90% of the xylose had been consumed. Chemical analysis of inhibitory pretreatment by-products indicated that the concentrations of heteroaromatic aldehydes (such as furfural), aromatic aldehydes, and an aromatic ketone decreased as a consequence of the aeration. This was attributed mainly to evaporation caused by the gas flow. The results indicate that further research is needed to fully exploit the advantages of LPMO without compromising fermentation conditions.
Metal-based nanoparticle in cancer treatment: lessons learned and challenges
Authors: Hheidari Ali , Mohammadi Javad , Ghodousi Maryam , Mahmoodi Mohammadreza , Ebrahimi Sina , Pishbin Esmail , Rahdar Abbas
Published: July 2024

Cancer, being one of the deadliest diseases, poses significant challenges despite the existence of traditional treatment approaches. This has led to a growing demand for innovative pharmaceutical agents that specifically target cancer cells for effective treatment. In recent years, the use of metal nanoparticles (NPs) as a promising alternative to conventional therapies has gained prominence in cancer research. Metal NPs exhibit unique properties that hold tremendous potential for various applications in cancer treatment. Studies have demonstrated that certain metals possess inherent or acquired anticancer capabilities through their surfaces. These properties make metal NPs an attractive focus for therapeutic development. In this review, we will investigate the applicability of several distinct classes of metal NPs for tumor targeting in cancer treatment. These classes may include gold, silver, iron oxide, and other metals with unique properties that can be exploited for therapeutic purposes. Additionally, we will provide a comprehensive summary of the risk factors associated with the therapeutic application of metal NPs. Understanding and addressing these factors will be crucial for successful clinical translation and to mitigate any potential challenges or failures in the translation of metal NP-based therapies. By exploring the therapeutic potential of metal NPs and identifying the associated risk factors, this review aims to contribute to the advancement of cancer treatment strategies. The anticipated outcome of this review is to provide valuable insights and pave the way for the advancement of effective and targeted therapies utilizing metal NPs specifically for cancer patients.
Methods and instruments for the transformative design of the public space: insight from the Ancient Canal of Yangzhou in China
Authors: Fanzini Daniele , Miao Siqi , Casoni Giorgio
Published: July 2024

This study applies transformative technologies, specifically Geographic Information Systems (GIS) and environmental psychology tools, within the Yangzhou Canal area, enhancing public space utility and resident satisfaction. Using a mixed-methods approach, including a survey with 213 responses and field observations, we explored the socio-psychological impacts of the canal as a historic urban landscape. Questionnaire responses revealed correlations between the spatial characteristics and their usage, perceived and actual uses of space, exploring the canal’s cultural value, visiting methods and temporality, social and spatial characterization, and the residents’ preferences for different canal spaces. Observational studies at three key sites highlighted distinct patterns in activity and engagement, offering insights into locals’ preferences and behaviors. The findings contribute to urban design by providing a research framework that integrates historical canals with contemporary urban life, ultimately enhancing community satisfaction and livability. This study introduces a novel approach by systematically implementing GIS and environmental psychology to analyze and improve public spaces.
Polyploid giant cancer cells: origin, possible pathways of formation, characteristics, and mechanisms of regulation
Authors: Liu Pan , Wang Lili , Yu Huiying
Published: July 2024

Polyploid giant cancer cells (PGCCs) are characterized by the presence of either a single enlarged nucleus or multiple nuclei and are closely associated with tumor progression and treatment resistance. These cells contribute significantly to cellular heterogeneity and can arise from various stressors, including radiation, chemotherapy, hypoxia, and environmental factors. The formation of PGCCs can occur through mechanisms such as endoreplication, cell fusion, cytokinesis failure, mitotic slippage, or cell cannibalism. Notably, PGCCs exhibit traits similar to cancer stem cells (CSCs) and generate highly invasive progeny through asymmetric division. The presence of PGCCs and their progeny is pivotal in conferring resistance to chemotherapy and radiation, as well as facilitating tumor recurrence and metastasis. This review provides a comprehensive analysis of the origins, potential formation mechanisms, stressors, unique characteristics, and regulatory pathways of PGCCs, alongside therapeutic strategies targeting these cells. The objective is to enhance the understanding of PGCC initiation and progression, offering novel insights into tumor biology.
Traditional Chinese medicine lowering lipid levels and cardiovascular events across baseline lipid levels among coronary heart disease: a meta-analysis of randomized controlled trials
Authors: Xie Lihua , Liu Jia , Wang Xiaochi , Liu Birong , Li Jiaqi , Li Jingen , Wu Huanlin
Published: July 2024

Background

Dyslipidemia is a critical driver in the development of coronary heart disease (CHD), which further exacerbates the risk of major adverse cardiovascular events (MACEs). Chinese herbal medicine (CHM) plays an important role in the regulation of lipid levels and improvement of prognosis. However, few systematic reviews report whether the efficacy of CHM therapy for regulating lipid levels and lowering cardiovascular events is associated with baseline lipid levels.

Methods

Randomized controlled trials assessing efficacy of CHM for lipid profiles and MACEs among patients with CHD were searched in six databases. Two authors independently extracted studies according to a predesigned form. Cochrane risk of bias tool and Grading of Recommendations Assessment, Development, and Evaluation system were used to assess the methodological quality of the included studies. The primary outcomes were blood lipid levels and MACEs including cardiovascular mortality, non-fatal myocardial infarction, revascularization, angina pectoris, heart failure, and non-fatal stroke across baseline lipid levels. The secondary outcomes were individual components of the primary outcomes.

Results

A total of 23 trials with 7,316 participants were included in this study. Altogether 377 cardiovascular events occurred in 3,670 patients in the CHM group, while 717 events occurred in 3,646 patients in the Western medicine–alone group. Compared with the Western medicine alone, additional CHM significantly lowered low-density lipoprotein cholesterol (LDL-C) [MD = −0.46, 95% CI (−0.60 to −0.32), P < 0.00001, I2 = 96%]. The risk reduction in MACEs associated with CHM vs. Western medicine therapy was 0.52 [95% CI (0.47–0.58), P < 0.00001, I2 = 0%], but varied by baseline LDL-C level (P = 0.03 for interaction). Triglycerides (TG) level was also significantly lowered by additional CHM vs. Western medicine alone [MD = −0.27, 95% CI (−0.34 to −0.20), P < 0.00001, I2 = 81%], and risk reduction for MACEs also varied with baseline TG, with greater risk reduction in higher baseline TG subgroups (P = 0.03 for interaction). Similar results were observed with total cholesterol and high-density lipoprotein cholesterol.

Conclusion

Compared with Western medicine alone, additional CHM was associated with lower risk of cardiovascular events and improvement of lipid profiles. Risk reduction for cardiovascular events was associated with baseline LDL-C and TG levels.

Systematic Review Registration

https://www.crd.york.ac.uk/PROSPERO, identifier CRD42023425791.
Case Report: Mechanical hemolysis resulting from left ventricular outflow tract obstruction after aortic valve replacement relieved by transapical beating-heart septal myectomy
Authors: Kang Qingwen , Tian Jie , Zhu Ying , Zhou Wei , Wei Xiang , Liu Yani
Published: July 2024

Background

Aortic stenosis (AS) in combination with left ventricular outflow tract obstruction (LVOTO) has occasionally been reported. However, making a precise diagnosis and successfully treating this combination is challenging due to the hemodynamic interaction between the two conditions.

Case summary

A 56-year-old male patient who had been diagnosed with severe AS and asymmetric left ventricular hypertrophy underwent aortic valve replacement (AVR) and a conventional septal myectomy. Immediately after the procedure, significant systolic anterior motion and mitral regurgitation developed, necessitating a surgical mitral edge-to-edge repair. Ten days after the procedure, the patient developed hematuria and LVOTO, which was confirmed by echocardiography. Because the LVOTO might have been the cause of the hematuria, the patient underwent alcohol septal ablation, but this had little effect. Three months later, a transapical beating-heart septal myectomy (TA-BSM) was performed in our hospital. Postoperatively, the LVOTO had been significantly ameliorated and the hematuria had resolved.

Conclusion

For patients with AS and LVOTO due to a hypertrophic interventricular septum, inadequate amelioration of the LVOTO after AVR may lead to severe hemolytic hematuria. TA-BSM is a minimally invasive, safe, and effective surgical procedure for ameliorating LVOTO in patients with aortic valve prostheses.
Geological and glaciological controls of 21,700 active methane seeps in the northern Norwegian Barents sea
Authors: Serov Pavel , Andreassen Karin , Winsborrow Monica , Mattingsdal Rune , Patton Henry
Published: July 2024

Due to tectonic uplift in the Cenozoic and numerous shelf-wide glaciations during the Quaternary, ∼1–2.5 km of sedimentary overburden has been eroded from the Barents Sea shelf, leading to the exhumation and partial uncapping of hydrocarbon accumulations. Widespread natural gas and oil leakage from the glacially eroded middle-upper Triassic reservoir directly into the water column has been documented at the Sentralbanken high in the northern Norwegian Barents Sea. However, it remains unclear whether the hydrocarbon leakage occurs only from the middle-upper Triassic reservoir units in geological settings exceptionally conducive to hydrocarbon leakage, or if other reservoir formations contributed to the release of hydrocarbons into the water column. It is also not clear whether complete erosion of the caprock is a prerequisite for widespread liberation of natural gas and oil from glacially eroded reservoirs across Arctic continental shelves. Here we analyze multibeam echosounder data covering ∼5,000 km2 and a suite of high-resolution P-cable seismic lines from a range of geological structures across the northern Norwegian Barents Sea. Our analyses reveal that ∼21,700 natural gas seeps originate from exhumed, faulted and variably eroded structural highs bearing a range of Mesozoic reservoir formations. All investigated structural highs fuel seabed methane release hotspots with no exception. Evident from observations of seismic anomalies, fluid accumulations are pervasive in the subsurface and likely to continue fuelling seabed gas seepage into the future. We also document that gas seepage through faults piercing overburden, caprocks and reaching potential reservoir levels is pervasive at all investigated structural highs. On the Storbanken high and the Kong Karl platform, such fault-controlled seepage is more prevalent than seepage from reservoir formations subcropping below the seafloor. Using a simple parametrization approach, we estimate that seeps identified within our multibeam data coverage produce a seabed methane flux of 61 x 107 mol/yr (9,803 ton/yr), which is one to two orders of magnitude higher than other globally known submarine methane seepage provinces. Fluxes of methane from sea water to the air above the thermogenic gas seep provinces in the northern Norwegian Barents Sea remain to be determined.
Association between telomere length and erectile dysfunction: a cross-sectional study
Authors: Chen Xiaobao , Liu Binhong , Zhou Junkai , Lin Junwei , Jiang Wei , Xie Ruoyun
Published: July 2024

Background

Leukocyte telomere length (LTL) serves as a significant biomarker of aging. Erectile dysfunction (ED) is a commonly observed condition among middle-aged and older men. The objective of this study is to explore the potential association between LTL and ED.

Methods

We utilized data from the National Health and Nutrition Examination Survey (NHANES) to examine the association between LTL and ED. Weighted multivariate regression analyses were performed as the primary statistical method. Subgroup analyses were conducted to investigate specific population subsets, and restricted cubic spline (RCS) analyses were employed to assess the non-linear relationship between LTL and ED.

Results

The results of weighted multivariate regression analyses revealed a negative correlation between LTL and the risk of ED. Individuals with ED exhibited shorter LTL compared to those without ED. For each unit increase in LTL, there was a 54% reduction in the risk of ED (odds ratios[OR] 0.46, 95% confidence intervals[CI] 0.25-0.85). When LTL was considered as a categorical variable, the group with the longest LTL (Q5) had a 44% lower risk of ED compared to the group with the shortest LTL(Q1) (OR 0.56, 95% CI 0.39-0.81). A non-linear relationship was observed between TL and ED. Various sensitivity analyses were conducted to validate the stability of the results, and consistent findings were obtained.

Conclusion

The negative association between leukocyte LTL and ED suggests that delaying the shortening of LTL may decrease the risk of ED.
Constrained distributionally robust optimization for day-ahead dispatch of rural integrated energy systems with source and load uncertainties
Authors: Zhang Zhihui , Yang Song , Ma Yunting , Sun Shumin , Yu Peng , Yang Fei
Published: July 2024

As a deep connection between agriculture and energy, the rural integrated energy system (RIES) is a micro-scale supply–distribution–storage–demand network, which provides an important means to realize the utilization of rural clean energy. This paper proposes a day-ahead scheduling model of the RIES to improve its economical effectiveness, where three energy carriers, namely, biogas, electric power, and heat, are integrated. To address the source and load uncertainties composed of photovoltaic power, power load, and heat load, this paper develops a constrained distributionally robust optimization (CDRO), which optimizes the cost expectation related to the extreme distribution to enhance the robustness, while limiting the loss of cost expectation in the historical distribution to ensure economical effectiveness. In addition, an ambiguous set of the source and load uncertainties incorporating 1-norm and infinity-norm constraints is established, which realizes a flexible adjustment for the conservativeness of CDRO. The distributionally robust dispatch is formulated as a deterministic programming in a two-stage solving framework, where the subproblem uploads its extreme probability distribution to the master problem, and these two problems are iteratively optimized until the convergence. Finally, the numerical simulations in a modern farm park prove the performance of the constructed dispatch model and the flexibility of CDRO in balancing the economical effectiveness and robustness of the dispatch.
Long-term effects on immunological, inflammatory markers, and HIV-1 reservoir after switching to a two-drug versus maintaining a three-drug regimen based on integrase inhibitors
Authors: Saborido-Alconchel Abraham , Serna-Gallego Ana , Trujillo-Rodriguez María , Muñoz-Muela Esperanza , Álvarez-Ríos Ana I. , Lozano Carmen , Llaves-Flores Silvia , Espinosa Nuria , Roca-Oporto Cristina , Herrero Marta , Sotomayor Cesar , Gutierrez-Valencia Alicia , Lopez-Cortes Luis F.
Published: July 2024

Objective

To compare the long-term effects on immune parameters, inflammation, and HIV-1 reservoir after switching to a two-drug (2DR) versus maintaining an integrase inhibitor (InSTI)-based three-drug regimen (3DR).

Methods

Cross-sectional study in which HIV-1 treatment-naïve people started and maintained an InSTI-based 3DR or, at different times, switched to 2DR (dolutegravir or darunavir/cobicistat + lamivudine). CD4+ and CD8+ T-cell activation and exhaustion, plasma concentrations of hs-CRP, D-dimer, P-selectin, IL-1β, IL-6, TNF-α, IFN-γ, IP-10, sTNFR-I/II, MIP-1α/β, I-FABP, LBP, sCD14, sCD163, MCP-1, and cellular-associated HIV-1-DNA and -RNA were quantified by flow cytometry, different immunoassays, and droplet digital PCR, respectively. The U de Mann-Whitney test evaluated differences between 3DR and 2DR. Immune recovery was evaluated using a general linear model for repeated measures adjusted for different co-variables.

Results

Fifty participants per group were included. The median time on 3DR was 82 months for the 3DR group and 30 months for the 2DR group, after which it switched to 2DR for a median of 57 months. We did not find differences between both groups in any of the parameters analyzed. Specifically, some values in 3DR and 2DR were hs-CRP, 0.92 mg/L (0.45–2.23) vs. 1.23 (0.61–2.38); D-dimer, 190.0 µg/L (150.0–370.0) vs. 190.0 (150.0–397.5); IL-6, 2.8 pg/mL (1.3–5.3) vs. 3.2 (2.1–4.7); sCD14, 4.5 ng/mL (3.3–6.2) vs. 5.0 (3.6–6.1), respectively, all p ≥ 0.399.

Conclusion

In the long term, switching to 2DR does not negatively affect immunologic parameters, inflammatory markers, or HIV-1 reservoir.

Clinical trial registration

identifier NCT04076423.
Protein-A immunoadsorption combined with immunosuppressive treatment in refractory primary Sjögren’s syndrome coexisting with NMOSD: a case report and literature review
Authors: Fan Wei , Chen Xuyan , Xiao Pingping , Wei Bo , Zhang Yi , Huang Jinmei , Wu Shufan , Lu Liangjing
Published: July 2024

The treatment of primary Sjögren’s syndrome (pSS) coexisting with neuromyelitis optica spectrum disorder (NMOSD) using protein-A immunoadsorption combined with immunosuppressive therapy has rarely been reported. Herein, we present the case of a 35-year-old female diagnosed with pSS concomitant with NMOSD (pSS-NMOSD) who demonstrated a positive response to protein-A immunoadsorption after failing to respond to therapy comprising high-dose intravenous methylprednisolone (IVMP) and intravenous immunoglobulin (IVIG). Within one week of receiving three sessions of immunoadsorption combined with immunosuppressive treatment, the patient’s clinical symptoms (blurred vision, paraparesis, and dysfunctional proprioception) significantly improved. Additionally, a rapid decrease in the circulating levels of Aquaporin-4 immunoglobulin G antibodies (AQP4-IgG), immunoglobulin (Ig) A, IgG, IgM, erythrocyte sedimentation rate (ESR), and rheumatoid factor (RF) were observed. Magnetic resonance imaging (MRI) further revealed a significant reduction in the lesions associated with longitudinal extensive transverse myelitis. During the follow-up period, prednisolone was gradually tapered to a maintenance dose of 5-10 mg/day, whereas mycophenolate mofetil (MMF) was maintained at 1.0-1.5 g/day. The patient’s condition has remained stable for four years, with no signs of recurrence or progression observed on imaging examination. Therefore, this case suggests that protein A immunoadsorption may represent a potentially effective therapeutic option for patients with pSS-NMOSD who are refractory to conventional treatments.
Constructing a prognostic model for hepatocellular carcinoma based on bioinformatics analysis of inflammation-related genes
Authors: Li Yinglian , Fang Yuan , Li DongLi , Wu Jiangtao , Huang Zichong , Liao Xueyin , Liu Xuemei , Wei Chunxiao , Huang Zhong
Published: July 2024

Background

This study aims to screen inflammation-related genes closely associated with the prognosis of hepatocellular carcinoma (HCC) to accurately forecast the prognosis of HCC patients.

Methods

Gene expression matrices and clinical information for liver cancer samples were obtained from the Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC). An intersection of differentially expressed genes of HCC and normal and GeneCards yielded inflammation-related genes associated with HCC. Cox regression and the minor absolute shrinkage and selection operator (LASSO) regression analysis to filter genes associated with HCC prognosis. The prognostic value of the model was confirmed by drawing Kaplan–Meier and ROC curves. Select differentially expressed genes between the high-risk and low-risk groups and perform GO and KEGG pathways analyses. CIBERSORT analysis was conducted to assess associations of risk models with immune cells and verified using real-time qPCR.

Results

A total of six hub genes (C3, CTNNB1, CYBC1, DNASE1L3, IRAK1, and SERPINE1) were selected using multivariate Cox regression to construct a prognostic model. The validation evaluation of the prognostic model showed that it has an excellent ability to predict prognosis. A line plot was drawn to indicate the HCC patients’ survival, and the calibration curve revealed satisfactory predictability. Among the six hub genes, C3 and DNASE1L3 are relatively low expressed in HCCLM3 and 97H liver cancer cell lines, while CTNNB1, CYBC1, IRAK1, and SERPINE1 are relatively overexpressed in liver cancer cell lines.

Conclusion

One new inflammatory factor-associated prognostic model was constructed in this study. The risk score can be an independent predictor for judging the prognosis of HCC patients’ survival.
Evidence of mutual non-verbal synchrony in learners with severe learning disability and autism, and their support workers: a motion energy analysis study
Authors: Glass Devyn , Yuill Nicola
Published: July 2024

Introduction

Some research indicates that neurodivergent people are less likely than “neurotypical” people to adapt their movements to a partner’s movements to facilitate interpersonal motor synchrony. Researchers therefore suggest synchrony deficits underlie the social differences associated with autism and other neurodivergences. Intensive Interaction (II) is a client-led approach, where Learning Support Workers (LSW) follow the lead of learners to create balanced and reciprocal interactions.

Methods

We aimed to examine the balance of synchrony in learners with autism and Severe Learning Disabilities and their LSWs in a special education college where learners had prior experience with II. Using Motion Energy Analysis, we assessed the degree to which each partner acted as a leader, and hence which partner acted as a follower, during moments of close synchrony.

Results

Overall, learners and LSWs showed higher than chance synchrony. There were no differences in the degree to which each partner led the moments of synchrony, or the amount pairs synchronized with zero-lag, where there was no delay between each partners’ movements.

Discussion

The equal balance of leading and following in the learner and LSW pairs demonstrates that both partners consistently adapted their movements to their partner’s movements to facilitate synchrony. The findings tentatively challenge the notion of a synchrony deficit in autism and suggest synchrony can be present in cross-neurotype pairs in comfortable and engaging conditions. We discuss the potential for client-led, movement-based approaches to support smooth interactions across neurotypes.
Unveiling the role of O(6)-methylguanine-DNA methyltransferase in cancer therapy: insights into alkylators, pharmacogenomics, and others
Authors: Chen Lizhen , Wen Alex
Published: July 2024

Cancer chemotherapy is advancing as we understand how cellular mechanisms and drugs interact, particularly involving the enzyme MGMT, which repairs DNA damage that can cause cancer. This review examines MGMT’s role in DNA repair, its impact on chemotherapy, and its complex interaction with radiation therapy. MGMT activity can both protect against mutations and cause drug resistance. Modulating MGMT could improve treatment efficacy and tailoring therapy to MGMT status may enhance patient outcomes. Understanding MGMT is crucial for developing precise cancer treatments and advancing patient care.
Molecular mechanisms and therapeutic potential of lithium in Alzheimer’s disease: repurposing an old class of drugs
Authors: Shen Yanxin , Zhao Meng , Zhao Panpan , Meng Lingjie , Zhang Yan , Zhang Guimei , Taishi Yezi , Sun Li
Published: July 2024

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss. Despite advances in understanding the pathophysiological mechanisms of AD, effective treatments remain scarce. Lithium salts, recognized as mood stabilizers in bipolar disorder, have been extensively studied for their neuroprotective effects. Several studies indicate that lithium may be a disease-modifying agent in the treatment of AD. Lithium’s neuroprotective properties in AD by acting on multiple neuropathological targets, such as reducing amyloid deposition and tau phosphorylation, enhancing autophagy, neurogenesis, and synaptic plasticity, regulating cholinergic and glucose metabolism, inhibiting neuroinflammation, oxidative stress, and apoptosis, while preserving mitochondrial function. Clinical trials have demonstrated that lithium therapy can improve cognitive function in patients with AD. In particular, meta-analyses have shown that lithium may be a more effective and safer treatment than the recently FDA-approved aducanumab for improving cognitive function in patients with AD. The affordability and therapeutic efficacy of lithium have prompted a reassessment of its use. However, the use of lithium may lead to potential side effects and safety issues, which may limit its clinical application. Currently, several new lithium formulations are undergoing clinical trials to improve safety and efficacy. This review focuses on lithium’s mechanism of action in treating AD, highlighting the latest advances in preclinical studies and clinical trials. It also explores the side effects of lithium therapy and coping strategies, offering a potential therapeutic strategy for patients with AD.
Evaluation of the anti-obesity effect of Sambucus nigra L. (elderberry) and Vitex agnus-castus L. (chasteberry) extracts in high-fat diet-induced obese rats
Authors: Ulusoy Şeyma , İnal Ebrar , Küpeli Akkol Esra , Çiçek Mahmut , Kartal Murat , Sobarzo-Sánchez Eduardo
Published: July 2024

The aim of this study was to investigate the effects of S. nigra L. and V. agnus-castus L. plants on obesity in vivo. Extracts were prepared from S. nigra leaves, flowers, fruits and from V. agnus-castus leaves, flowers, and fruits using 100% water and 70% ethanol. The total phenol and flavonoid contents of the extracts were quantified spectrophotometrically. The findings revealed that the ethanol extracts of V. agnus-castus and S. nigra flowers had the highest phenolic content, while the ethanol extracts of S. nigra flowers and V. agnus-castus leaves had the highest flavonoid content. Qualification and quantification of the phenolic contents of the extracts were carried out using liquid chromatography-high resolution mass spectrometry (LC-HRMS) analyses. The study investigated the effects of various extracts on plasma levels of leptin, insulin, triiodothyronine (T3), thyroxine (T4), triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL) and lipase enzyme in obesity-induced rats. The results showed that the ethanol extract of V. agnus-castus flowers, as well as the ethanol and water extracts of V. agnus-castus leaves, resulted in body weight reduction in rats with obesity. Additionally, these extracts were found to decrease serum levels of LDL, triglycerides, leptin, lipase, TNF-α, and IL-1β while increasing levels of HDL and adiponectin. The LC-HRMS results demonstrated that all three extracts exhibited relatively high concentrations of luteolin-7-glycoside and kaempferol, in comparison to the other extracts. The ethanol extract of V. agnus-castus flowers contained 653.04 mg/100 g of luteolin-7-glycoside and 62.63 mg/100 g of kaempferol. The ethanol extract of V. agnus-castus leaves contained 1,720.26 mg/100 g of luteolin-7-glycoside and 95.85 mg/100 g of kaempferol. The water extract of V. agnus-castus leaves contained 690.49 mg/100 g of luteolin-7-glycoside and 194.41 mg/100 g of kaempferol. The study suggests that the ethanol extract of V. agnus-castus flowers and leaves, as well as the water extract of V. agnus-castus leaves, may have potential benefits in treating obesity. However, further controlled clinical studies are necessary to evaluate the clinical efficacy of V. agnus-castus in treating obesity and investigate the in vivo anti-obesogenic effects of luteolin-7-glycoside and kaempferol separately, both in their pure form and in combination.
Dynamic evolutionary analysis of opinion leaders’ and netizens’ uncertain information dissemination behavior considering random interference
Authors: Ma Lin , Li Bowen , Wang Junyao
Published: July 2024

This paper investigates the decision-making behaviors of opinion leaders and netizens in the context of uncertain information dissemination with the aim of effectively managing online public opinion crises triggered by major sudden events. The decision-making behaviors of opinion leaders are categorized into positive and negative guidance, while those of netizens are classified into acceptance and nonacceptance. Using an evolutionary game model, this study introduces random factors to examine their influence on the decision-making processes of both groups. A stochastic evolutionary game model is constructed to analyze the behaviors of opinion leaders and netizens in the context of uncertain information dissemination. The evolutionary stability strategies and stochastic evolutionary processes of the model are analyzed based on the theory of Itô stochastic differential equations. The impacts of key variables such as random disturbances, the degree of psychological identification of netizens with opinion leaders, and the intensity of government penalties for those spreading negative information are examined through numerical simulations. The findings indicate that opinion leaders evolve to make stable strategies more rapidly than netizens do; random disturbances slow the evolution of stable strategies for both groups but do not alter their strategic choices; a higher degree of psychological identification increases the likelihood of netizens adopting the views of opinion leaders; and as punitive measures intensify, both opinion leaders and netizens are inclined to choose strategies of positive guidance and acceptance. The results of this study offer theoretical insights and decision-making guidance for future government strategies for managing similar online collective behaviors.
The genetic characterization of grapevines prospected in old Serbian vineyards reveals multiple relationships between traditional varieties of the Balkans
Authors: Tello Javier , Todić Slavica , Ferradás Yolanda , Nikolic Miroslav , Sabovljević Aneta , Ivanišević Dragoslav , Tomanović Željko , Grbić Miodrag , Martínez-Zapater José Miguel , Ibáñez Javier
Published: July 2024

Serbia preserves a high number of local grape varieties, which have been cultivated across the country for centuries. Now, these ancient varieties are in the spotlight, and there is a global trend towards their recovery and characterization because they can revitalize regional, national and international grape and wine sectors. In addition, their genetic study can be useful to find new pedigree relationships to reveal how local varietal assortment evolved over time. Here, the genetic characterization of 138 grapevines from old Serbian vineyards revealed 59 different genetic profiles, 49 of which were identified as grapevine varieties whose origin in the country could be linked to some major Serbian historical periods. Most of the genetic profiles found in this work arranged in a complex pedigree network that integrates numerous grapevine varieties from diverse Balkan countries, agreeing with an intense exchange of plant material among Balkan regions for centuries. This analysis identified some varieties as important founders of Balkan genetic resources, like ‘Alba Imputotato’, ‘Braghina Rosie’, ‘Coarna Alba’, and ‘Vulpea’. After deepening into their genealogy, these major direct founders might have ultimately derived from ‘Visparola’, an ancient variety of likely Balkan origin with a major founding role in some European regions. Our results also indicated the genetic singularity of the grapevine resources from the Balkans when compared to those from other relevant winemaking regions, supporting the interest of their detailed study to evaluate their oenological potential and for the eventual identification of useful traits to counteract current viticulture challenges.
Technology of plant factory for vegetable crop speed breeding
Authors: He Rui , Ju Jun , Liu Kaizhe , Song Jiali , Zhang Shuchang , Zhang Minggui , Hu Youzhi , Liu Xiaojuan , Li Yamin , Liu Houcheng
Published: July 2024

Sustaining crop production and food security are threatened by a burgeoning world population and adverse environmental conditions. Traditional breeding methods for vegetable crops are time-consuming, laborious, and untargeted, often taking several years to develop new and improved varieties. The challenges faced by a long breeding cycle need to be overcome. The speed breeding (SB) approach is broadly employed in crop breeding, which greatly shortens breeding cycles and facilities plant growth to obtain new, better-adapted crop varieties as quickly as possible. Potential opportunities are offered by SB in plant factories, where optimal photoperiod, light quality, light intensity, temperature, CO2 concentration, and nutrients are precisely manipulated to enhance the growth of horticultural vegetable crops, holding promise to surmount the long-standing problem of lengthy crop breeding cycles. Additionally, integrated with other breeding technologies, such as genome editing, genomic selection, and high-throughput genotyping, SB in plant factories has emerged as a smart and promising platform to hasten generation turnover and enhance the efficiency of breeding in vegetable crops. This review considers the pivotal opportunities and challenges of SB in plant factories, aiming to accelerate plant generation turnover and improve vegetable crops with precision and efficiency.
2-(2-Phenylethyl)chromones increase in Aquilaria sinensis with the formation of agarwood
Authors: Sun Yuanyuan , Wang Meiran , Yu Meng , Feng Jian , Wei Jianhe , Liu Yangyang
Published: July 2024

Obtained from Aquilaria Lam. and Gyrinops Gaertn., agarwood is a prestigious perfume and medicinal material in the world. Its primary chemical constituents and indicators of agarwood's development are 2-(2-phenylethyl)chromones (PECs). However, how PECs affect its quality, accumulation, and transformation pattern is still unclear. The present study investigated this issue by monitoring resin filling in agarwood generated by the whole-tree agarwood-inducing technique over a span of a year, observing the ethanol extract concentration at different sampling times, and statistically examining PECs in agarwood from each sampling period. In agarwood, the resin accumulated over time, except during the 4th–6th month due to the creation of a barrier layer. The relative content of total PECs demonstrated an overall increase throughout the year but a decrease from the 4th month to the 6th month, and the relative content of 19 PECs that persisted throughout the year was positively correlated with the content of ethanol extracts. In addition, the process of chromone accumulation was accompanied by the production and transformation of different types of chromones, with flindersia type 2-(2-phenylethyl)chromones, epoxy-2-(2-phenylethyl)chromones, and diepoxy-2-(2-phenylethyl)chromones being the major chromone components; in addition, the content of 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones kept increasing after 6 months of agarwood formation. Three main trends were identified from 58 analogs of PECs, each with notable variation. The first type had the highest content at the beginning of resin formation. The second type had the highest content at 6 months and then started to decrease, and the third type had a slowly increasing content. As a whole, this study systematically investigated the accumulation of PECs during injury-induced agarwood production in A. sinensis, which is of scientific significance in resolving the transformation of PECs and revealing the secret of agarwood formation.
The Brunswik Lens Model: a theoretical framework for advancing understanding of deceptive communication in autism
Authors: Blackhurst Tiegan , Warmelink Lara , Roestorf Amanda , Hartley Calum
Published: July 2024

Due to differences in social communication and cognitive functioning, autistic adults may have greater difficulty engaging in and detecting deception compared to neurotypical adults. Consequently, autistic adults may experience strained social relationships or face increased risk of victimization. It is therefore crucial that research investigates the psychological mechanisms that are responsible for autistic adults’ difficulties in the deception process in order to inform interventions required to reduce risk. However, weaknesses of extant research exploring deception in autism include a heavy focus on children and limited theoretical exploration of underlying psychological mechanisms. To address these weaknesses, this review aims to introduce a system-level theoretical framework to the study of deception in autistic adulthood: The Brunswik Lens Model of Deception. Here, we provide a comprehensive account of how autism may influence all processes involved in deception, including: Choosing to Lie (1), Producing Deception Cues (2), Perceiving Deception Cues (3), and Making the Veracity Decision (4). This review also offers evidence-based, theoretical predictions and testable hypotheses concerning how autistic and neurotypical adults’ behavior may differ at each stage in the deception process. The call to organize future research in relation to a joint theoretical perspective will encourage the field to make substantive, theoretically motivated progress toward the development of a comprehensive model of deception in autistic adulthood. Moreover, the utilization of the Brunswik Lens Model of Deception in future autism research may assist in the development of interventions to help protect autistic adults against manipulation and victimization.
Depression, anxiety, and poor well-being at discharge from psychiatric hospitals: prevalence and risk factors
Authors: Mao Wanying , Shalaby Reham , Owusu Ernest , Elgendy Hossam Eldin , Agyapong Belinda , Eboreime Ejemai , Silverstone Peter , Chue Pierre , Li Xin-Min , Vuong Wesley , Ohinmaa Arto , Taylor Valerie , Greenshaw Andrew J. , Agyapong Vincent I. O.
Published: July 2024

Background

Being ready for discharge is vital to successful hospital-to-home transitions. For many patients, however, the transition from psychiatric hospital care to outpatient care can be challenging. An in-depth understanding of the mental health conditions of patients at discharge is crucial and instructive for recovery research.

Objective

The purpose of this study was to determine the prevalence and risk factors of depression, anxiety, and poor well-being symptoms among patients who are about to be discharged from psychiatric units in Alberta, Canada. Our aim was to help determine the prevalence of anxiety, depression, and overall well-being among the general psychiatric inpatient population in Alberta before discharge and the potential factors which may influence this.

Methods

This epidemiological study used a cross-sectional quantitative survey from March 8, 2022, to November 5, 2023, to assess depression, anxiety, and well-being. Participants were invited to complete an online questionnaire that contained demographics, clinical information, and responses to the PHQ-9, GAD-7, and WHO-5 questionnaires. SPSS version 25 was used to analyze the data. Descriptive, univariate, and multivariate regression analyses were employed.

Result

The study found that the prevalence of likely depression, anxiety, and poor well-being among patients about to be discharged was 37.1%, 56.4%, and 48.3%, respectively. Based on a logistic regression model, there was a statistically significant association between anxiety, depression, and poor well-being diagnoses and multiple socio-demographic and clinical factors such as ethnicity, primary mental health diagnoses, education level, housing status, depression, anxiety, and well-being at baseline.

Conclusion

Mental health assessment at discharge is a critical step in the recovery and transition of care. There is still a need for further research to identify the underlying causes and robust predictors of mental health symptoms in patients about to be discharged and to provide appropriate interventions and supportive resources both before and following discharge. Future research utilizing these findings may help identify key opportunities to improve outcomes for patients after discharge.
Physical literacy and health of Chinese medical students: the chain mediating role of physical activity and subjective well-being
Authors: Yang Xiaoqi , Wang Miaomiao , Wang Jiangong , Zhang Shujie , Yang Xiaoxia , Zhao Liangyuan
Published: July 2024

Background/objective

While Physical Literacy has been highlighted as a determinant in health in recent study, there is a dearth of studies examining its effect on physical health, and there is a little in the way of empirical data linking Physical Literacy to health outcomes. Accordingly, further empirical research is needed to clarify the mechanisms by which Physical Literacy affects physical health. The purpose of this study was to verify the role of medical students’ Physical Literacy on Health-related quality of life as well as to explore the chain mediating role of Physical Activity and Subjective Well-being in it.

Methods

This study utilized a cross-sectional study design. The Physical Literacy, Health-related Quality of Life, Physical Activity ratings, and Subjective Well-being of students at Shanxi Medical University were all measured using an online survey administered in September 2023. A total of 1968 valid questionnaires were returned. First, descriptive statistics and correlation analysis were performed using SPSS software. Second, PROCESS was used to test the mediating role. Finally, we used structural equation modeling (Amos) to test the model fit.

Results

There is a significant correlation between all variables. After mediation effects analysis, we found that there were three indirect pathways of physical literacy on health-related quality of life: a single mediating effect of physical activity, a single mediating effect of subjective well-being, and a chained mediating effect of physical activity-subjective well-being.

Conclusion

The mediating role of physical activity and subjective well-being on the relationship between physical literacy and health-related quality of life has been confirmed. Our research results support the integration of physical literacy into physical education teaching and the modification of curriculum content by physical education teachers as part of efforts to enhance students’ physical activity levels, subjective well-being levels, and overall health. This study provides a new perspective for intervention in improving the health of medical students.