bluuebunny/crossref_metadata_2025 huggingface dataset:
Hubungan Riwayat Positif COVID-19 dengan Perubahan Pola Menstruasi pada Wanita Usia Subur di Poltekkes Kemenkes Bengkulu Tahun 2022
Authors: Yusriadi Septiyana , Nugraheni Diah Eka , Sholihat Suci , Dewi Ratna
Published: January 2023

Coronavirus Disease 2019 atau yang lebih dikenal dengan COVID-19 adalah penyakit menular yang disebabkan oleh Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Diketahui jika virus ini dapat menyerang organ reproduksi dan menyebabkan perubahan siklus menstruasi berupa siklus menstruasi menjadi lebih panjang, aliran darah lebih berat, durasi yang lama dan tingkat nyeri bertambah. Penelitian ini bertujuan untuk mengetahui Hubungan Riwayat Positif COVID-19 dengan Perubahan Pola Menstruasi pada Wanita Usia Subur di Poltekkes kemenkes Bengkulu Tahun 2022.

Desain penelitian yang digunakan adalah analitik observasional dengan pendekatan retrospektif . Populasi penelitian adalah seluruh dosen perempuan dan mahasiswi Poltekkes Kemenkes Bengkulu yang berjumlah 2696 orang. Sampel dalam penelitian ini sebanyak 155 orang yang diambil dengan teknik purposive sampling. Data dianalisis menggunakan uji chi square.

 Hasil penelitian didapatkan 125 orang (80.6%) memiliki riwayat positif COVID-19 dan sebagian besar (54.2%) mengalami perubahan pola menstruasi. Berdasarkan hasil analisis bivariat menggunakan uji chi square menunjukkan nilai p = 0.000 (p-value < 0.05) hal itu berarti adanya pengaruh yang signifikan antara riwayat positif dengan perubahan pola menstruasi di Poltekkes Kemenkes Bengkulu.

Diharapkan kedepannya, penelitian ini dapat dilanjutkan dengan melakukan uji laboratorium untuk mengetahui hubungan secara lebih akurat.

 

Kata Kunci : Coronavirus, COVID-19, Menstruasi
Hazards In Poultry Feed Production: An Appraisal From The Halal Perspective
Authors: Mohd Ashraf Amalina , Abd Rahman Fadilah
Published: January 2023

Animal feed is any processed, semi-processed of raw materials or compound which are fed to animals. Poultry feed are food for farm poultry, including chickens, ducks, geese and other domestic birds (Gallus domesticus), whether it is in mash, crumbles or pellets form. Feed supply is central to all animal production systems and any factor that affects the security of the feed supply is a significant constraint to production. In Malaysia, most of the poultry feed comprises of 95% of the sources that are imported and only 5% are obtained locally. In this situation, feed producers are responsible to communicate with crop producers and at the same time connected with primary food producers involved, such as poultry breeders. These phenomena are crucial in maintaining the halal integrity along the supply chain. To produce halal food materials, it is important to make sure that the feed fed to edible animals are Ḥalālan ṭoyyiban. This paper reviews the hazards presence in poultry feed and its production which include biohazards, chemical hazards and physical hazards. In so doing, it employs library research methodology by reviewing the relevant literatures and analysed using content analysis method. Further to that, it also appraises the presence of the respective hazards from the halal perspective. From the halal point of view, the sources of human food shall not only be halal, but shall also be safe for human consumption, non-poisonous and non-hazardous to human health. In the context of poultry feed, the usage of antibiotics, GMOs with hazardous issue or potential toxicity or allergenicity, toxin contamination and presence of physical contaminants in poultry feed, if not properly controlled and regulated seriously, adverse effects might take place in human and this is indeed not in line with the goal of the Shariah to safeguard the interests of human and the universe, to protect life and lineage, and to bring benefits and repelling harms. Nevertheless, considering that contaminants are present everywhere, and that total elimination is almost impossible, taking proactive actions to reduce their presence to the minimum level possible is in compliance with the spirit of Maqasid Shariah. This could be done by putting in place a comprehensive legislation for the control of several of these chemical compounds, pathogens and physical contaminants in poultry feed, or by implementing feed safety management system such as HACCP in feed plants. In addition, to protect the interest of the Muslim consumers particularly in Malaysia, it is also recommended that a Halal standard for Poultry Feed Production should be developed.
Pengetahuan, Persepsi dan Perilaku Konsumer Mualaf di negeri Terengganu dalam Menggunakan Produk Makanan Halal
Authors: Awang Azarudin , Abdullah Norhana @ Ng Siew Boey , Izudin Irdina Safiah
Published: January 2023

Salah satu ciri seorang Muslim yang komited terhadap ajaran agamanya ialah memelihara dirinya daripada mengambil makanan yang dilarang oleh agama. Komuniti Mualaf merupakan kelompok yang baru memeluk agama Islam dan lazimnya mereka memahami ajaran Islam secara berperingkat termasuk dalam aspek-aspek yang menyentuh konsumerisme dalam sesuatu produk makanan. Objektif kajian ini ialah melihat tahap pengetahuan dan persepsi mualaf terhadap produk makanan halal. Selanjutnya menganalisis sikap mereka terhadap konsumerisme produk makanan dalam menjalani kehidupan sebagai Muslim yang baharu. Kajian ini menggunakan kaedah kuantitatif melalui edaran borang soal selidik ke atas 110 orang mualaf di negeri Terengganu. Data dianalisis melalui perisisan SPSS 22.0 menggunakan peratus, min dan sisihan piawai. Secara keseluruhannya, hasil kajian menunjukkan tahap pengetahuan, persepsi dan sikap mualaf di negeri Terengganu dalam mengambil dan menggunakan produk halal adalah tinggi. Hasil dapatan ini penting kerana ia mampu memberi informasi kepada Majlis Agama dan badan-badan yang berkaitan tentang perlunya bimbingan yang berterusan diberikan kepada mualaf terhadap kepentingan konsumerisme Islam.
The Relationship between the Government Size and Economic Growth in South Sumatra
Authors:   Sriwijaya University, Palembang, Indonesia, Rahmatullah Khairunisah , Azwardi Azwardi ,   Sriwijaya University, Palembang, Indonesia, Sukanto Sairuki ,   Sriwijaya University, Palembang, Indonesia
Published: January 2023

In general, many factors, including government spending, influence economic growth. In many theoretical and empirical studies, government spending is seen from the ratio between government spending and Gross Domestic Product (GDP) or government size. This research aims to examine the influence of government size on economic growth in districts/cities of South Sumatra Province. The government size to be analyzed is the amount of government spending on public services, housing and public facilities, education, and health. The data used in this study is secondary data for the 2010-2020 and covers 15 regencies/cities. The data was obtained from the Central Statistics Agency and the Regional Financial and Asset Management Agency. The analytical technique used in this research is descriptive analysis technique and quantitative analysis. Klassen Typology Approach was used to identify the regencies/cities with fast growth and the relatively lagging regencies/cities of South Sumatra Province. The study results show that government spending on public services and health has a positive and significant effect on economic growth. Meanwhile, the government spending on housing and public facilities has a positive and insignificant effect. In contrast, the government spending on education has a negative and significant impact on economic growth. This study recommends local governments increase the allocation of regional expenditure to sectors that lead to economic growth, especially in newly created regions.
The Taxation of IT and Digital Communications Entities' Activity: Its Legislation and Accounting in Ukraine
Authors:   Uman National University of Horticulture, Uman, Ukraine, Melnyk Liudmyla , Matros Olena ,   Uman National University of Horticulture, Uman, Ukraine, Krochak Oksana ,   Uman National University of Horticulture, Uman, Ukraine, Ratushna Olha ,   Uman National University of Horticulture, Uman, Ukraine
Published: January 2023

Modern challenges of the economy are an adaptation to the changes taking place in the world community. New forms of interaction in human society, transferred to the digital space, are gaining increasing importance. Economic entities must respond fully to the demands of the digital environment. At the same time, the state mustn't reduce its fiscal control over such digital operations. The purpose of the article is to analyze the legislative regulation of taxation of business entities that work in areas related to IT technologies and activities carried out on the Internet. This study covers difficulties and debatable issues arising in the taxation of business entities due to the implementation of digitalization. The authors systematized the features of taxation of the activities of Diya City residents following the current tax legislation of Ukraine. The article contains detailed explanations of which electronic services are subject to VAT and which transactions are not electronic services. The main key points for non-residents and providers of electronic services regarding VAT payment have been systematized. Attention is paid to issues related to the taxation of transactions with cryptocurrency. The authors performed a detailed analysis of the Draft Law of Ukraine “On Amendments to the Code of Criminal Procedure and Some Other Laws of Ukraine Regarding Transactions with Cryptocurrency”, and individual tax consultations of the State Tax Service of Ukraine. It was established that when taxing operations with virtual assets, particularly cryptocurrency, it is necessary to be guided by the norms of the Tax Code of Ukraine. In individual conflicting situations that arise due to various types of operations with cryptocurrency, it is recommended to contact the State Tax Service for individual clarifications.
Determinants of Fraudulent Tendencies on Public Accountancy in Indonesia
Authors:   State University of Malang, Malang, Indonesia, Fauzia Firda Nur , Pujiningsih Sri ,   State University of Malang, Malang, Indonesia, Makaryanawati Makaryanawati ,   State University of Malang, Malang, Indonesia
Published: January 2023

Accounting fraud is the intentional manipulation of accounting data to create a false appearance of corporate financial health or obtain personal benefits. If problems like this occur continuously, it will cause fraud that is detrimental to many parties. Therefore, efforts to minimize fraud need to do an in-depth analysis of the causes of fraud. One of them is analyzing the tendency of public accountant fraud through the fraud hexagon perspective. Georgios L. Vousinas developed the fraud hexagon in 2019. The fraud hexagon explains that fraud can occur due to six factors, namely, 1) pressure, 2) opportunity, 3) rationalization, 4) capability, 5) arrogance and 6) collusion. This theoretical concept is the basis of this research. This research aims to obtain empirical evidence regarding the influence of the fraud hexagon factor on the tendency of public accountant fraud accompanied by a moderating variable of professional ethics. The questionnaire method was used to collect data for analysis. The sample in this study is all public accountants working at public accounting firms registered with the Indonesian Ministry of Finance (Kementerian Keuangan) in 2022. The total sample is 107 respondents. To analyze data Moderated Regression Analysis (MRA) was used. The results of this study are pressure, rationalization, opportunity, capability, and arrogance do not affect public accountant fraud tendencies. Collusion is a factor that influences the tendency of public accountants to commit fraud. The ethics of the accounting profession do not moderate the hexagon fraud factor's effect on public accountants' tendency to commit fraud. Other related parties can use the results of this study to prevent public accountant fraud through policies related to collusive practices because only collusion increases the desire of public accountants to commit fraud.
NÖ Baurecht
Authors: Kienastberger Gerald , Stellner-Bichler Anna
Published: January 2023

Praxistaugliche Hilfestellungen von den Mitgestalter*innen der jüngsten Novellen Die 3. Auflage des Praxiskommentars legt anlässlich der Novellen 2020 und 2021 zu den wichtigsten niederösterreichischen bau- und raumordnungsrechtlichen Vorschriften ihren Schwerpunkt ganz bewusst auf eine praxisnahe Erläuterung der wesentlichen Inhalte. Das Autor*innenteam steht aufgrund seines Tätigkeitsbereiches im ständigen Austausch mit den Betroffenen und Anwender*innen der NÖ Bauordnung und weiß daher über die alltäglichen Problemstellungen Bescheid. Diese Erfahrungen fließen in Form von umfangreichen Anmerkungen zu den neuen Gesetzen und praxistauglichen Hilfestellungen in den Kommentar mit ein. Alle mit baurechtlichen Fragestellungen befassten Behördenorgane in Gemeinden und Bezirksverwaltungsbehörden sowie Sachverständige, Planer*innen und Bauträger erhalten damit Unterstützung aus erster Hand. Der Kommentar umfasst und berücksichtigt die Novelle 2021 und Neufassung zur NÖ Bauordnung 2014 die Novellen 2020 zum NÖ Raumordnungsgesetz 2014 die NÖ Bautechnikverordnung 2014 inklusive der OIB-Richtlinien 1 bis 6 in der für Niederösterreich geltenden Fassung das NÖ Straßengesetz 1999 die wichtigsten Nebengesetze und Durchführungsverordnungen zu den Gesetzen
Comparison of intraocular pressure and retinal nerve fibre layer thickness in pre-menopausal and post-menopausal women attending outpatient department of BSMMU
Authors: Rahman Shaila , Ahmed Md Sharfuddin , Kabir Md Showkat , Chowdhury Nirupam , Hoque Mohammed Moinul , Hossain Muhammad Mahbub , Hassan Shah Noor , Rahman Shish , Khan Nusaffarin , Jahan Sharmin
Published: January 2023

In a menopausal lady, a reduced level of estrogen hormone leads to changes in the intraocular pressure (IOP) and retinal nerve fiber layer (RNFL) thickness in the eyes. This comparative study was carried out in the Outpatient Departments (OPD) of the Community Ophthalmology and Ophthalmology of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from April 2017 to June 2019 to identify any difference in IOP and RNFL thickness in pre-menopausal and post-menopausal women aged 40-65 years. In this study, 60 pre-and post-menopausal women were included. Participants 40-50 years old with irregular menstruation were classified as group A, while those 51-65 years old with no menstruation for at least 12 months were classified as group B. More than one-fourth (26.7%) of participants had HTN in group A and 53.3% in group B. HTN was significantly associated with group B. The rise in menopausal age had a significant impact on the mean IOP and RNFL. The mean IOP in right eye (RE) was 11.80 (3.31) mm of Hg in Group A and 15.63 (3.01) mm of Hg in Group B. The mean IOP in left eye (LE) was 12.27(3.78) mm of Hg and 15.47(2.84) mm of Hg in Group A and Group B, respectively. The mean IOP of both eyes was 12.03±3.48 mmHg in Group A and 15.55±2.82 mmHg in Group B. The mean difference of IOP in RE, LE and both were statistically significant between the two groups. The mean RNFL in RE was 103.97±7.42 μm in Group A and 98.90±}6.21 μm in Group B. The mean RNFL in LE was 101.87±6.69 μm and 97.97±6.65 μm in Group A and Group B, respectively. The mean RNFL of both eyes was 102.92±7.77 μm in Group A and 98.45±7.86 μm in Group B. The mean RNFL was statistically significant between the two groups. Post-menopausal women are at an increased risk of developing elevated IOP and thin RNFL than premenopausal women.
BSMMU J 2022; 15(2): 61-64
Frequency and outcome of thrombocytopenia in neonates who are at risk of developing thrombocytopenia - a prospective observational study
Authors: Saha Sarbari , Roy Debabrata , Jahan Ismat , Hassan Shabuj Mohammad Kamrul , Choudhury Sadeka , Mannan MA , Shahidullah Mohammod , Dey Sanjoy Kumer
Published: January 2023

Thrombocytopenia is the commonest hematological abnormality encountered in the neonatal intensive care unit (NICU). This prospective, observational study was conducted among 78 consecutive at-risk neonates admitted in NICU, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from September 2016 to August 2017. Platelet count was measured in all at risk neonates at enrollment and less than 1,50,000/cmm was consiered as the cut off point for determining thrombocytopenia. Platelet count was measured every alternate day till discharge or normalisation of platelet count if the initial platelet count was low. If initial platelet count revealed normal, then the babies were followed up clinically if they develop any further risk condition for developing thrombocytopenia. During the period from enrollment to discharge, if any baby develops thrombocytopenia at any time then baby was defined as thrombocytopenic. Overall 39.7%patients found to be thrombocytopenic among 78 at-risk neonates. Pregnancy induced hypertension (PIH), neonatal sepsis and small for gestational age (SGA), intra uterine growth restriction(IUGR), prematurity, necrotizing enterocolitis (NEC) were significantly associated with thrombocytopenia. Sepsis and NEC were found to be independent risk factor for thrombocytopenia. Regarding outcome, length of hospital stay was significantly more in thrombocytopenic patients than non-thrombocytopenic patients. Death rate was also higher in thrombocytopenic patients in comparison to non-thrombocytopenic patients.
BSMMU J 2022; 15(2): 115-120
Outcome of classical and reversal stapedotomy in otosclerosis
Authors: Parvez SM Rasel , Akhtar Nasima , Rahman Mohammad Habibur , Sakender Md Sha , Rahaman Md Lutfor , Nusrat Fahmida , Monirul Md , Gunguly Debobroto , Chakma Rasel
Published: January 2023

Classical and reversal stapedotomy both are exclusively done in otosclerosis but definite information regarding surgical advances, postoperative results, complications and information about how and in which patients these surgical techniques should exclusively be used are a source of continuous discussions. This prospective observational study was conducted in the Department of Otolaryngology-Head & Neck Surgery, Bangabandhu Sheikh Mujib Medical University, Shahbagh, Dhaka from July 2019 to December 2020 o compare the outcomes of classical and reversal stapedotomy in patients with otosclerosis. Total 28 cases of otosclerosis who underwent stapedotomy were divided in to two groups i.e. Group A (classical stapedotomy) & Group B (reversal stapedotomy) with 14 patients in each group. All patients were followed up post-operatively up to 3 months with Pure-tone audiometry (PTA). There is no significant difference between classical and reversal stapedotomy approach in terms of hearing improvement and complications. Chorda tympani injury was the main complication in both the groups. Regarding hearing gain and complications there was no significant difference between classical and reversal stapedotomy approach.
BSMMU J 2022; 15(2): 121-126
Multiple arterial and venous thromboses due to protein S deficiency - a case report
Authors: Paul Susanta Kumar , Rahman Mohammed Atiqur , Ahmed Shamim , Chakrabortty Rajashish , Majumder Shuvo , Hamza Md
Published: January 2023

Abstract not available
BSMMU J 2022; 15(2): 132-137
A 19-year-old boy with intra-oral discharging sinus for 28 days
Authors: Das Panna , Hosain Mozammal , Saha Shuvendu , Moral Md Ali Asgor
Published: January 2023

Abstract not available
BSMMU J 2022; 15(2): 138-140
Prothrombin time and activated partial thromboplastin time in women with gestational diabetes mellitus
Authors: Mahjabeen Samira , Selim Shahjada , Mustari Marufa
Published: January 2023

Impact of gestational diabetes mellitus (GDM) on the coagulation system still remains unclear and there is limited data available regarding haemostatic changes in GDM in Bangladesh. This study was aimed at determining plasmaprothrombin time (PT), activated partial thromboplastin time (APTT) in women with GDM. This cross sectional study encompassed 44 GDM (age: 28.5±3.8 years, BMI: 27.2±4.0kg/m2; mean±SD) and equal number of pregnant women with normal glucose tolerance (NGT) diagnosed on the basis of WHO criterion 2013 at or after 24 weeks of gestation to see PT and APTT. Plasma glucose was measured by glucose oxidase method, PT and APTT by automated coagulation analyzer. There was no statistically significant difference between the GDM and NGT groups for PT (12.3±0.5 vs. 12.2±0.4 sec, mean±SD; P=0.40) or APTT (30.53±1.01 vs. 30.9±4.5 sec, mean±SD; P=0.56). In conclusion, PT and APTT do not differ between women with or without GDM.
BSMMU J 2022; 15(3): 146-150
Association of clinico-epidemiological features with locally advanced stage of cervical cancer patients presenting at Bangabandhu Sheikh Mujib Medical University, Bangladesh
Authors: Anika Afsana Sharmin , Bari Md Abdul , Alam Sarwar , Mollah Md Nazir Uddin , Bhuiyan Md Zillur Rahman , Sharmin Sadia , Ruma Rokaya Sultana , Islam Md Hafizul , Talukdhar Sajib Kumar
Published: January 2023

Cervical cancer is one of the most prevalent gynecological cancers in women in Bangladesh. The objective of this study was to assess the clincoepidemiological association with the histology of locally advanced cervical cancer. We have done this observational study in the department of Clinical Oncology at Bangabandhu Sheikh Mujib Medical University from July to December 2019. Sixty-six biopsy-proven locally advanced (stage IIB to IVA) squamous cell carcinoma of uterine cervix were included in this study. The mean age of patients at diagnosis was 48.5 (±8.6) years. Commonly observed epidemiological characteristics of locally advanced carcinoma cervix were illiteracy (46.9%), oral contraceptive use (62.1%), multi para (78.7%) and early marriage (74.2%). Most frequent clinical presentation was post-coital bleeding (37.87%). Most patients presented in stage IIB (65.1%). The association of the stages of the disease with age, parity, oral contraceptive use, age at marriage and clinical presentation were statistically nonsignificant, whereas illiteracy was statistically significant. Most women had poor awareness regarding their need for routine check-up and screening as indicated by the late medical care seeking. Social stigma might have played some role. Relevant programmes should create awareness among women, especially those with socioeconomic deprivation.
BSMMU J 2022; 15(3): 175-179
Comparison of serum homocysteine level in young and middle-aged adult patients with coronary artery disease
Authors: Begum Rokshana , Bhuiyan Mohammad Monzurul Alam , Ferdousi Sheuly , Yesmin Mst Shaila , Paul Debatosh , Sultana Tuhin , Rahman Md Quddusur , Islam Md Saiful , Rahim Khandoker Abdur , Khaled Mohammad Fakhrul Islam
Published: January 2023

Deaths due to coronary artery disease have been increasing in young people aged <40. Studies have reported an association between these deaths with hyperhomocysteinemia. The aim of this study was to compare serum homocysteine levels in middle-aged patients with coronary artery disease. This cross-sectional study was conducted among 52 cardiology inpatients of Bangabandhu Sheikh Mujib Medical University, Dhaka, from March 2021 to February 2022. Among them, 26 were young adults (<40 years, Group I), and 26 were middle-aged (≥40 years, Group II). Serum homocysteine was measured in all of them using an automated immunoassay analyzer. The younger patients had higher (P=0.001) median homocysteine (interquartile range) level, 13.5 (7.7 –28.4 mmol/L) compared to the middle-aged group, 10.0 (5.9 – 38.5 mmol/L). The hyperhomocysteinemia (>15 mmol/L) was 16.2% in Group I compared to 12.4% in Group II (P=0.001). Therefore, control measures for keeping homocysteine levels within the normal range in young people might be useful.
BSMMU J 2022; 15(3): 197-200
Association of Ki-67 expression in radical cystectomy specimens of infiltrating urothelial carcinoma with histopathological parameters
Authors: Rahman Papiya , Khan Kamrul Hasan , Afroz Sadia , Rahman Mohammad Mosiur , Rashid Jubyda Shahnur , Emita Umama-Tun-Nesa
Published: January 2023

Urothelial carcinoma is the most common neoplasm of urinary bladder. Antigen Ki-67 is a nuclear protein that is necessary for cellular proliferation. The aim of this study was to determine the association of expression of Ki-67 with histopathological parameters in radical cystectomy specimens of histologically diagnosed cases of infiltrating urothelial carcinoma. This is a cross-sectional study conducted among 36 cases of infiltrating urothelial carcinoma collected from Department of Pathology, Bangabandhu Sheikh Mujib Medical University. Histopathological parameters i.e. morphologic variants, stage (pT), lympho-vascular invasion, perineural invasion and lymph node metastasis were assessed. Ki-67 immunohistochemistry were performed. Mean ±SD age of the patients was 58.9±13.8 years. Among the morphological variants, 64% cases were microscopically arranged in papillary pattern. Eighteen (50%) patients underwent surgical intervention at stage pT2. Lympho-vascular invasion, perineural invasion and lymph node metastasis were identified in 12 (33.3%), 9 (25%) and 13 (48.1%) of the cases, respectively. Among the morphological parameters, Ki-67 shows association with pathological stages and lymph node metastasis. The use of Ki-67 immunomarker along with grading and staging may provide significant prognostic information in urothelial carcinoma of the urinary bladder.
BSMMU J 2022; 15(3): 186-191
PELAKSANAAN PERJANJIAN KREDIT DENGAN JAMINAN GADAI DEPOSITO BERJANGKA PADA PT. BANK NAGARI
Authors: Ramadhona Ana , Khair Umul
Published: January 2023

Perjanjian  jaminan  gadai  deposito  Berjangka  pada  PT. Bank Nagari dalam  praktek  perbankan,  ditetapkan  prinsip  pemberian  kredit ,  yang  melarang  bank  menanggung  risiko  akibat  pemberian  kredit, sehingga setiap pinjaman yang diberikan harus ada jaminannnya diantaranya  adalah  jaminan  deposito berjangka dengan tahapan: melakukan pengikatan kredit sebagai perjanjian pokok, pengikatan deposito dilakukan dengan pembuatan akta perjanjian gadai antara pemilik deposito dengan pihak bank, penyerahan bilyet deposito berjangka yang dijaminkan, pemilik deposito berjangka/pemberi gadai memberikan kuasa kepada pemegang gadai yaitu pihak bank untuk melakukan pencairan deposito berjangka sedangkan hambatan yang dihadapai dalam pelaksanaan perjanjian jaminan gadai deposito berjangka pada PT. Bank Nagari adalah akta perjanjian yang dibuat dibawah tangan, debitur telah melakukan wanprestasi dalam bentuk kredit macet/kurang lancar.  Upaya yang dilakukan untuk mengatasi kendala tersebut adalah seharusnya dalam pembuatan Perjanjian Kredit dan Pembuatan akta gadai deposito berjangka antara bank dengan Calon Nasabah/debitur dengan akta notaris agar lebih kuat status hukumnya dan perjanjian tersebut memiliki kekuatan pembuktian yang sempurna. disarankan agar akta perjanjian kredit deposito tersebut dibuat dengah akta notaris,  terhadap pelaksanaan perjanjian yang wan prestasi maka penyelesaian dengan jalan perdamaian,  memberikan pengarahan agar nasabah secara maksimal dapat membayar angsuran  tepat pada waktunya.Kata Kunci : Perjanjian Kredit,  jaminan, gadai, Deposito
Hypertension in Patients Receiving Dialysis: A Review of the Current Clinical Approach
Authors: Rowan Colm , Mahony Stephen , Redahan Lynn
Published: January 2023

Cardiovascular disease is a leading cause of morbidity and mortality in end-stage renal disease (ESRD). Hypertension plays a major contributory role, resulting in progressive left ventricular hypertrophy, and increasing the risk of sudden cardiac death. The prevalence and pathophysiological mechanisms differ fundamentally from the non-dialysis-dependent population.

Sodium restriction can be as effective as antihypertensive medication in mitigating the haemodynamic effects resulting from impaired sodium handling. Tailoring dialysate sodium may enhance diffusion and facilitate greater sodium elimination where dietary measures alone prove ineffective.

Unlike hypertension in the wider population, volume overload plays a major pathophysiological role in ESRD. Probing dry weight in patients on dialysis who are seemingly euvolaemic enables clinically significant blood pressure (BP) reduction, and translates to improvements in markers of future cardiovascular morbidity and mortality.

Pharmacotherapy remains an important aspect in controlling hypertension in dialysis. Although no large-scale studies have identified the optimal medical therapy, numerous meta-analyses and randomised control trials (RCT) have demonstrated the efficacy of angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARB), calcium channel blockers, β-blockers, and hydralazine/isosorbide dinitrate in the treatment of hypertension in ESRD. Whether the beneficial haemodynamic properties of mineralocorticoid receptor antagonists outweigh the risk of hyperkalaemia is the subject of ongoing RCTs. Numerous meta-analyses have demonstrated that adequate pharmacological control of BP translates to improved cardiovascular morbidity and mortality.

The fluctuation of volume status in the inter/intra-dialytic period complicates the diagnosis of hypertension in ESRD. As with patients not receiving dialysis, 24-hour blood pressure monitoring appears to have the greatest sensitivity in diagnosing hypertension and predicting outcomes from hypertension. Where resources are limited, home BP monitoring appears to have the greatest value.
Višeslojnost leksika Kerstnerovih Gruntovčana
Authors: Lasić Josip , Macan Željka , Marinković Marina
Published: January 2023

Jednim je od čimbenika koji određuje pojedinu društvenu zajednicu i specifičnost njezina govora (Pon 2009), a leksik se unutar pojedinoga govora pokazuje najuočljivijim indikatorom razlikovnosti te je općenito važnom sastavnicom jezika kao sredstva nacionalne integracije i nacionalne diferencijacije (Pranjković 2007, 488). Na oblikovanje je leksičke razine pojedinih hrvatskih govora bilo puno vanjskih utjecaja u smislu »ulaska« leksema iz drugih, uglavnom susjednih jezika i jezičnih sustava (Lisac 2003, 31). U radu1 se promatra leksik kultne hrvatske igrane serije Gruntovčani autora Mladena Kerstnera na temelju tekstova knjiga snimanja prvih pet epizoda. Riječ je o kajkavskome izričaju kojem je u osnovi autorov materinji ludbreški govor, prošaran i preslojen brojnim inodijalektalnim elementima.Cilj je istraživanja provedenoga u okviru ovoga rada predstavljanje i analiza slojevitosti leksika televizijske serije Gruntovčani koji se promatra iz nekoliko istraživačkih perspektiva – dijalektološke, socio-kulturne i semantičko-pragmatičke. U fokus istraživanja stavljena su tri leksička sloja koja se naziru u Kerstnerovu tekstu: naslijeđeni slavenski leksički sloj, posuđenice te internacionalizmi. Istraživanjem smo došli do triju spoznaja: 1. gruntovečke leksičke potvrde slavenskoga podrijetla umnogome se podudaraju s onima iz čakavskoga i štokavskoga sustava, te slovenskoga jezika, a zamjetan je i znatan broj novih tvorenica i riječi koje su svojstvene samo kajkavskomu narječju; 2. zamjetan je i velik broj posuđenica, pri čemu dominiraju germanizmi; 3. manji udio otpada na internacionalizme koji su u kajkavski sustav ušli i zbog onodobnih društveno-političkih okolnosti. Sve to upućuje na zaključak da je leksik Gruntovčana višeslojnoga karaktera, kao što su to i današnji organski mjesni govori.
PEMBERDAYAAN KELOMPOK TANI DALAM MENINGKATKAN HASIL PERTANIAN DI DESA ARJASARI KECAMATAN LEUWISARI KABUPATEN TASIKMALAYA
Authors: Malindir Gaston Otto , Mashud Aldi Budi
Published: January 2023

Pemberdayaan kelompok tani adalah serangkaian kegiatan yang dilakukan untuk meningkatkan pengetahuan dan keterampilan petani melalui pelatihan dan penyuluhan agar terwujudnya petani yang mandiri dan berdaya saing. Fenomena yang ditemukan dilapangan yaitu kurangnya pengetahuan dan keterampilan petani dalam menerapkan inovasi teknologi serta tidak terberdayakanya kelompok tani berakibat kepada hasil panen produksi yang mengalami fluktuasi atau naik turun setiap musim panennya. Tujuan penelitian ini yaitu tentang pemberdayaan kelompok tani oleh Pemerintah Desa Arjasari dengan menggunakan teori pemberdayaan dengan indikator bina manusia, bina usaha, bina lingkungan dan bina kelembagaan. Metode penelitian yang digunakan yaitu deskriptif kualitatif dengan teknik pengumpulan data studi pustaka dan studi lapangan melalui wawancara dan observasi. Hasil penelitian berdasarkan empat indikator tidak berjalan maksimal karena belum adanya upaya peningkatan kapasitas yang dilakukan Pemerintah Desa baik melalui pelatihan ataupun penyuluhan, adapun beberapa hambatan pelaksanaan pemberdayaan kelompok tani yaitu kurangnya perhatian, keterbatasan anggaran, dan lemahnya pengembangan jejaring kemitraan. Penulis memberikan saran kepada Pemerintah Desa agar melakukan pelatihan dan penyuluhan kepada kelompok tani secara rutin dan bertahap agar tercapainya kemandirian dan kesejahteraan petani.

Kata kunci : Pemberdayaan, Kelompok Tani, Pemerintah Desa
PENGARUH PENGGUNAAN MEDIA SOSIAL TWITTER TERHADAP PARTISIPASI POLITIK ONLINE MAHASISWA DI JAWA BARAT
Authors: Hady Surya Muhamad Satria , Pratamawaty Benazir Bona
Published: January 2023

Menurut beberapa penelitian, terdapat pengaruh penggunaan media sosial terhadap partisipasi politik seseorang. Oleh karena itu, penelitian ini bertujuan untuk mengetahui secara lebih spesifik pengaruh penggunaan media sosial Twitter terhadap partisipasi politik online mahasiswa di Jawa Barat. Metode yang digunakan dalam penelitian ini adalah deskriptif kuantitatif. Dalam penelitian ini, Peneliti menggambarkan apakah penggunaan media sosial Twitter dapat memengaruhi ataupun tidak mempengaruhi partisipasi politik mahasiswa di Jawa Barat. Populasi yang digunakan dalam penelitian ini adalah mahasiswa aktif yang berada di Jawa Barat. Teknik sampling yang digunakan yakni convenience sampling. Penelitian ini menggunakan kuesioner skala likert (5 poin) yang disebar melalui media sosial sebagai teknik pengumpulan data untuk mengumpulkan data primer. Dari hasil analisis data, diperoleh hasil yakni terdapat pengaruh penggunaan media sosial Twitter terhadap partisipasi politik online mahasiswa di Jawa Barat.
Pembinaan Strategi Persiapan Karir bagi Siswa SMK di Kota Batam
Authors: Fajrah Nofriani , Rasid Ridho Muhammat , Wangdra Yvonne , Zetli Sri , Tipa Handra
Published: January 2023

Sekolah Menengah Kejuruan salah satu pendidikan tingkat menengah atas yang menghasilkan sumber daya manusia yang siap pakai di industri. Hal ini ditunjukkan dengan lulusan Sekolah Menengah Kejuruan mempersiapkan kompetensi dan pengalaman siswa dengan melaksanakan kegiatan Praktek Kerja Lapangan (PKL) pada tingkat kelas XI atau XII. Kompetensi dan pengalaman tersebut akan menjadi modal bagi lulusan untuk dapat melanjutkan karir setelah lulus. Namun, kondisi dilapangan yang ditemukan masih banyak lulusan SMK yang masih kehilangan arah dan tujuan untuk melanjutkan karir. Oleh karena itu kegiatan pengabdian kepada masyarakat ini dilaksanakan bertujuan untuk memberikan pembinaan kepada siswa kelas XI dan kelas XII SMK di Kota Batam untuk persiapan melanjutkan karir setelah lulus. Salah satunya dengan memberikan pembinaan tentang pentingnya melanjutkan studi ke jenjang perguruan tinggi. Berdasarkan hasil pelaksanaan kegiatan pengabdian kepada masyarakat ini 50% peserta sudah mulai memahami perlunya pendidikan tinggi untuk mendukung persiapan karir.
A theoretical approach to improving interspecies welfare comparisons
Authors: Gaffney Leigh P. , Lavery J. Michelle , Schiestl Martina , Trevarthen Anna , Schukraft Jason , Miller Rachael , Schnell Alexandra K. , Fischer Bob
Published: January 2023

The number of animals bred, raised, and slaughtered each year is on the rise, resulting in increasing impacts to welfare. Farmed animals are also becoming more diverse, ranging from pigs to bees. The diversity and number of species farmed invite questions about how best to allocate currently limited resources towards safeguarding and improving welfare. This is of the utmost concern to animal welfare funders and effective altruism advocates, who are responsible for targeting the areas most likely to cause harm. For example, is tail docking worse for pigs than beak trimming is for chickens in terms of their pain, suffering, and general experience? Or are the welfare impacts equal? Answering these questions requires making an interspecies welfare comparison; a judgment about how good or bad different species fare relative to one another. Here, we outline and discuss an empirical methodology that aims to improve our ability to make interspecies welfare comparisons by investigating welfare range, which refers to how good or bad animals can fare. Beginning with a theory of welfare, we operationalize that theory by identifying metrics that are defensible proxies for measuring welfare, including cognitive, affective, behavioral, and neuro-biological measures. Differential weights are assigned to those proxies that reflect their evidential value for the determinants of welfare, such as the Delphi structured deliberation method with a panel of experts. The evidence should then be reviewed and its quality scored to ascertain whether particular taxa may possess the proxies in question to construct a taxon-level welfare range profile. Finally, using a Monte Carlo simulation, an overall estimate of comparative welfare range relative to a hypothetical index species can be generated. Interspecies welfare comparisons will help facilitate empirically informed decision-making to streamline the allocation of resources and ultimately better prioritize and improve animal welfare.
Evaluation of a yeast β-glucan blend in a pet food application to determine its impact on stool quality, apparent nutrient digestibility, and intestinal health when fed to dogs
Authors: Kilburn-Kappeler Logan R. , Aldrich Charles G.
Published: January 2023

Oral supplementation of β-glucans may be able to improve the health of companion animals. However, little is understood regarding the effects of yeast β-glucan on diet processing and intestinal function. Therefore, the objectives of this research were to determine the carry through of yeast β-glucan during extruded diet production and its impact on diet utilization by dogs. Three diets were formulated to contain increasing levels of a yeast β-glucan blend at 0, 0.012 and 0.023% inclusion. Processing inputs were held constant during extrusion to allow for evaluation of output parameters and physical characteristics of kibble. Yeast β-glucan concentration was analyzed in extruded diets using the glucan enzymatic method, resulting in >100% recovery. Twenty-four Labrador Retrievers were assigned to one of three dietary groups of 8 dogs each with an equal distribution of sex and age. Dogs were fed dietary treatments for 24-d adaption followed by 4-d total fecal collection. Feces were scored on a 1-5 scale, with 1 representing liquid diarrhea and 5 hard pellet-like with a fecal score of 3.5-4 considered ideal. Fresh fecal samples were collected for analysis of short chain fatty acid concentrations. Apparent total tract digestibility was calculated by total fecal collection (TFC) and titanium (TI) marker methods. Data were analyzed using a mixed model procedure in software (version 9.4, SAS Institute, Inc., Cary, NC). Dry bulk density, kibble diameter, and kibble length did not differ among dietary treatments. Intake was similar among dietary treatments (P > 0.05). Dogs required about 26% more food than estimated [130*BWkg0.75] to maintain body weight among all treatments. Fecal score was not different (P > 0.05) among dietary treatments but was lower than ideal at an average of 2.6. Nutrient digestibility was not affected (P > 0.05) by inclusion of the yeast β-glucan. By method, the TFC procedure resulted in higher (P< 0.05) digestibility values when compared to the TI procedure. In addition, yeast β-glucan did not alter short or branched chain fatty acid proportions. Overall, processing parameters, physical characteristics of kibble, stool quality, nutrient digestibility, and intestinal health in dogs were not affected by the yeast β-glucan blend.
Poria cocos polysaccharide—functionalized graphene oxide nanosheet induces efficient cancer immunotherapy in mice
Authors: Yang Jinning , Dong Xiaoxiao , Li Boye , Chen Tian , Yu Boyang , Wang Xiaoli , Dou Xiangnan , Peng Bo , Hu Qin
Published: January 2023

Introduction: Tumor vaccines that induce robust humoral and cellular immune responses have attracted tremendous interest for cancer immunotherapy. Despite the tremendous potential of tumor vaccines as an effective approach for cancer treatment and prevention, a major challenge in achieving sustained antitumor immunity is inefficient antigen delivery to secondary lymphoid organs, even with adjuvant aid.

Methods: Herein, we present antigen/adjuvant integrated nanocomplexes termed nsGO/PCP/OVA by employing graphene oxide nanosheet (nsGO) as antigen nanocarriers loaded with model antigen ovalbumin (OVA) and adjuvant, Poria cocos polysaccharides (PCP). We evaluated the efficacy of nsGO/PCP/OVA in activating antigen-specific humoral as well as cellular immune responses and consequent tumor prevention and rejection in vivo.

Results: The optimally formed nsGO/PCP/OVA was approximately 120–150 nm in diameter with a uniform size distribution. Nanoparticles can be effectively engulfed by dendritic cells (DCs) through receptor-mediated endocytosis, induced the maturation of DCs and improved the delivery efficiency both in vitro and in vivo. The nsGO/PCP/OVA nanoparticles also induced a significant enhancement of OVA antigen-specific Th1 and Th2 immune responses in vivo. In addition, vaccination with nsGO/PCP/OVA not only significantly suppressed tumor growth in prophylactic treatments, but also achieved a therapeutic effect in inhibiting the growth of already-established tumors.

Conclusion: Therefore, this potent nanovaccine platform with nanocarrier nsGO and PCP as adjuvants provides a promising strategy for boosting anti-tumor immunity for cancer immunotherapy.
Material characterization of GPX®: A versatile in situ solidifying embolic platform technology
Authors: Stewart Russell J. , Sima Monika , Karz Jessica , Jones Joshua P.
Published: January 2023

Endovascular embolization is a minimally invasive procedure during which blood flow to targeted tissues is selectively occluded. The list of clinical indications for embolization continues to expand. Liquid embolic agents are injectable compositions that transition into a solid or semi-solid form when introduced into blood vessels. The mechanism that triggers the liquid-to-solid transition is a key distinguishing feature of liquid embolic agents. GPX is a waterborne liquid embolic agent comprising oppositely charged polyelectrolytes: polyguanidinum and inorganic polyphoshate. In situ solidification is driven by electrostatic condensation of the polyelectrolytes, triggered by ionic strength differentials. We report in vitro characterization of the material properties of GPX, it is in vivo effectiveness in acute animal studies, and its potential for chemoembolization. The viscosity of GPX can be varied over a wide range by adjusting the polyguanidinium MW and/or concentration. Formulation of GPX with either tantalum microparticles (30 wt%) or iodinated radiocontrast agents (300 mgI ml−1) did not significantly change the flow behavior of GPX; the viscosity was independent of shear rate and remained within a clinically practical range (80–160 cP). Formulation of GPX with doxorubicin substantially increased viscosity at low shear rates and resulted in a power law dependence on shear rate. High contrast and effective vascular occlusion were demonstrated in both swine kidneys and rete mirabile. Contrast from iodinated compounds was temporary, dissipating within hours. The doxorubicin in vitro release profile was linear over 90 days. The results demonstrate that GPX is a versatile liquid embolic platform that can be formulated with a wide range of viscosities injectable at clinically practical flow rates, with either transient or permanent contrast, and that can provide prolonged zero-order delivery of doxorubicin to embolized tissues.
MAPK inhibitors dynamically affect melanoma release of immune NKG2D-ligands, as soluble protein and extracellular vesicle-associated
Authors: López-Borrego Silvia , Campos-Silva Carmen , Sandúa Amaia , Camino Tamara , Téllez-Pérez Lucía , Alegre Estibaliz , Beneitez Alexandra , Jara-Acevedo Ricardo , Paschen Annette , Pardo María , González Álvaro , Valés-Gómez Mar
Published: January 2023

Metastatic melanoma presents, in many cases, oncogenic mutations in BRAF, a MAPK involved in proliferation of tumour cells. BRAF inhibitors, used as therapy in patients with these mutations, often lead to tumour resistance and, thus, the use of MEK inhibitors was introduced in clinics. BRAFi/MEKi, a combination that has modestly increased overall survival in patients, has been proven to differentially affect immune ligands, such as NKG2D-ligands, in drug-sensitive vs. drug-resistant cells. However, the fact that NKG2D-ligands can be released as soluble molecules or in extracellular vesicles represents an additional level of complexity that has not been explored. Here we demonstrate that inhibition of MAPK using MEKi, and the combination of BRAFi with MEKi in vitro, modulates NKG2D-ligands in BRAF-mutant and WT melanoma cells, together with other NK activating ligands. These observations reinforce a role of the immune system in the generation of resistance to directed therapies and support the potential benefit of MAPK inhibition in combination with immunotherapies. Both soluble and EV-associated NKG2D-ligands, generally decreased in BRAF-mutant melanoma cell supernatants after MAPKi in vitro, replicating cell surface expression. Because potential NKG2D-ligand fluctuation during MAPKi treatment could have different consequences for the immune response, a pilot study to measure NKG2D-ligand variation in plasma or serum from metastatic melanoma patients, at different time points during MAPKi treatment, was performed. Not all NKG2D-ligands were equally detected. Further, EV detection did not parallel soluble protein. Altogether, our data confirm the heterogeneity between melanoma lesions, and suggest testing several NKG2D-ligands and other melanoma antigens in serum, both as soluble or vesicle-released proteins, to help classifying immune competence of patients.
Mimicking the neural stem cell niche: An engineer’s view of cell: material interactions
Authors: Yazdani Narges , Willits Rebecca Kuntz
Published: January 2023

Neural stem cells have attracted attention in recent years to treat neurodegeneration. There are two neurogenic regions in the brain where neural stem cells reside, one of which is called the subventricular zone (SVZ). The SVZ niche is a complicated microenvironment providing cues to regulate self-renewal and differentiation while maintaining the neural stem cell’s pool. Many scientists have spent years understanding the cellular and structural characteristics of the SVZ niche, both in homeostasis and pathological conditions. On the other hand, engineers focus primarily on designing platforms using the knowledge they acquire to understand the effect of individual factors on neural stem cell fate decisions. This review provides a general overview of what we know about the components of the SVZ niche, including the residing cells, extracellular matrix (ECM), growth factors, their interactions, and SVZ niche changes during aging and neurodegenerative diseases. Furthermore, an overview will be given on the biomaterials used to mimic neurogenic niche microenvironments and the design considerations applied to add bioactivity while meeting the structural requirements. Finally, it will discuss the potential gaps in mimicking the microenvironment.