bluuebunny/crossref_metadata_2025 huggingface dataset:
Study on the relationship between Cardio-cerebrovascular events and the level of Atherosclerosis evaluated by Heart-brain Integrated CTA
Authors: Yu Huan , Zhang Yue , Zhu Dong , Duan Kai , Hu Yi , Song Chunhua
Published: January 2020

Objective: To establish a one-stop cardio-cerebral vascular scanning technique based on double-source helical CT by analyzing the relationship between the nature of coronary artery, extracranial and extracranial vascular plaque, the degree of lumen stenosis and the occurrence and development of cardio-cerebrovascular disease (CCVD). Methods: the plaque properties, vascular stenosis degree, and plaque quantitative analysis results of coronary artery, extracranial and intracranial segments of coronary artery, extracranial and intracranial carotid artery in 39 patients who underwent combined heart-brain CTA scanning were analyzed. The correlation between the load degree of cardio-cerebrovascular plaque and cardio-cerebrovascular events was analyzed comprehensively. Results: there were significant differences in age, high-density lipoprotein, diabetes, hypertension, smoking, plaque nature, plaque location, plaque composition and NIHSS score between the two groups. Conclusion: the combination of heart and brain CTA can help to establish the best clinical predictive model to prevent and stop the occurrence and development of coronary heart disease and stroke in time.
Acupuncture for amnestic mild cognitive impairment (aMCI): study protocol for a pilot multicenter, randomized, parallel controlled trial
Authors: Zhang Jiayu , Kuang Xu , Tang Chunzhi , Xu Nenggui , Xiao Songhua , Xiao Lingjun , Wang Shengwen , Lu Liming , Zhang Liang
Published: January 2020

Background: Patients with amnesic mild cognitive impairment (aMCI) are more likely to develop Alzheimer's disease (AD) than corresponding age normal population. Because AD is irreversible, early intervention for aMCI patients seems important and urgent. We have designed a pilot multicenter, randomized, parallel controlled trial to assess the efficacy and safety of acupuncture on aMCI, and explore the feasibility of acupuncture in the treatment of aMCI, so as to provide a reference for large-sample clinical trials in the next stage. Method: We designed a pilot multicenter, randomized, parallel controlled trial. This trial aims to test the feasibility of carrying out a large-sample clinical trial. In this trial, 50 eligible patients with aMCI will be included and allocated to acupuncture group (n = 25) or sham acupuncture group (n = 25) at random. Subjects will accept treatment 2 times a week for 12 weeks continuously, with a total of 24 treatment sessions. We will select six acupoints (GV20, GV14, bilateral BL18 , bilateral BL23). For the clinical outcomes, the primary outcome is Montreal cognitive assessment (MoCA), which will be assessed from baseline to the end of this trial. And the secondary outcomes are Mini-mental State Examination (MMSE), Delayed Story Recall (DSR), Clinical Dementia Rating scale (CDR), Global Deterioration Scale (GDS), Activity of Daily Life (ADL), Alzheimer's Disease Assessment Scale-Cognitive Section (ADAS-cog), brain Magnetic Resonance Imaging (MRI) , brain functional Magnetic Resonance Imaging (fMRI) and Event-related potential (ERP) P300, which will be assessed before and after treatment. In addition, we will asses the safety outcomes from baseline to the end of this trial and feasibility outcome after treatment. We will evaluate neuropsychological assessment scale (MoCA, MMSE, ADAS-cog) at 3 months and 6months after treatment. Discussion: This pilot trial aims to explore the feasibility of the trial, and verify essential information of its efficacy and safety. This pilot study will provide a preliminary basis for carrying out a larger clinical trial of acupuncture on aMCI in near future. Trial registration: Chinese Clinical Trial Registry , ChiCTR1900021557. Registered on 27 February 2019, http://www.chictr.org.cn/showproj.aspx?proj=35460. Keywords: amnestic Mild Cognitive Impairment , Acupuncture, Clinical trial
Preemptive Infiltration with Betamethasone and Ropivacaine for Postoperative Pain in Laminoplasty or Laminectomy (PRE-EASE): A Study Protocol
Authors: Shrestha Niti , Wu Liang , Wang Xianodi , Jia Wenqing , Luo Fang
Published: January 2020

Background: Laminoplasty and laminectomy have been used for decades for the treatment of intraspinal space occupying lesions, spinal stenosis, disc herniation, injuries, etc. After these procedures, patients often experience severe postoperative pain at the surgical site. Intense immediate postoperative pain after many spinal procedures makes its control of utmost importance.Preemptive injection of local anesthetics can significantly reduce postoperative pain during rest and movement, however, the analgesic effect is maintained for a relatively short period of time. Whether betamethasone combined with local anesthetic for laminoplasty or laminectomyhas better short-term and long-term effects than the local anesthetic alone has not been reported yet. Method: The PRE-EASEtrial is a prospective, randomized, open-label, blinded endpoint, single-center clinical study including 116 participants scheduled for elective laminoplasty or laminectomy, with a 6 months’ follow-up process. Preemptive local infiltration with betamethasone and ropivacaine (treatment group) or ropivacaine alone (control group) throughout the entire thickness of the planned incision site will be performed by the surgeon, prior to making the incision. The primary outcome will be the cumulative butorphanol consumption within the first 48 hours’ postoperative period. Discussion: This study will add significant new knowledge to the effect and feasibility of preemptive local infiltration of betamethasone for postoperative pain management in laminoplasty and laminectomy.
Weight management barriers and facilitators after breast cancer in Australian women: a national survey
Authors: Ee Carolyn , Cave Adele Elizabeth , Naidoo Dhevaksha , Bilinski Kellie , Boyages John
Published: January 2020

Background Breast cancer is the most common cancer in women worldwide. Weight gain after breast cancer is associated with poorer health outcomes. The aim of this study was to describe how Australian breast cancer survivors are currently managing their weight.Methods Online cross-sectional survey open to any woman living in Australia who self-identified as having breast cancer, between November 2017 and January 2018.Results We received 309 responses. Most respondents described their diet as good/excellent and reported moderate-high levels of weight self-efficacy. Despite this, the proportion of overweight/obesity increased from 47% at time of diagnosis to 67% at time of survey. More than three quarters of respondents did not receive any advice on weight gain prevention at the time of diagnosis. 39% of women reported being less active after cancer diagnosis, and and few weight loss interventions were perceived to be effective. Facilitators were structured exercise programs, prescribed diets, and accountability to someone else, while commonly cited barriers were lack of motivation/willpower, fatigue, and difficulty maintaining weight. Women who cited fatigue as a barrier were almost twice as likely to be doing low levels of physical activity or no physical activity than women who did not cite fatigue as a barrier.Conclusions We report high levels of concern about weight gain after BC and significant gaps in service provision around weight gain prevention and weight management. Women with BC should be provided with support for weight gain prevention in the early survivorship phase, which should include structured physical activity and dietary changes in combination with behavioural change and social support. Weight gain prevention or weight loss programs should address barriers such as fatigue. More research is required on the effectiveness of diet and exercise interventions in BC survivors, particularly with regard to weight gain prevention.
Collective occurrence of rhabdomyolysis after high-intensity resistance training--- A prospective study
Authors: Tu Haitao , Cai Xiaoqing , Wang Liangliang , Wu Xingbo , Zhang Liangyou , Lu Huan , Wang Chao , Luo Yuanyuan , Yu Xuguang
Published: January 2020

Background: Rhabdomyolysis is a syndrome characterized by muscle necrosis and release of intracellular muscle components into systemic circulation. Common causes include high-intensity exercise, crush injury, high fever, drugs, and inflammation. Here, we have a prospective observational study of collective rhabdomyolysis caused by infrequent short-term high-intensity exercise. Methods: The patients were a group of adolescents, of which 35 developed severe muscle pain and dark-brown urine after military training and were hospitalized, while others developed mild symptoms and returned to school after relief of symptoms following outpatient treatment. We used SPSS 13.0 to calculate the sample mean and standard deviation of various laboratory indicators. Results: The average serum creatinine kinase was 33532.43±39982.95 U/L, and average serum lactate dehydrogenase was 1816.97±1413.59 U/L at the time of admission. When they were discharged, the above two indicators became 1902.2±1366.37 U/L and 210.31±61.27 U/L. Signs and symptoms improved in all patients after the intravenous injection of average 5000ml within 5.5 days of normal saline and balance solution and implementation of a bed rest regimen. No complications occurred (e.g., acute renal failure, disseminated intravascular coagulation, or electrolyte imbalance). All patients were relieved of symptoms and discharged after an average of 5.47 days of hospitalization. Of these, 20 patients were prescribed medical treatment and returned to the clinic within 1 month after discharge. Conclusions: Suddenly and dramatically increase the amount of exercises in a short period of time is easy to cause rhabdomyolysis. We hope that everyone can avoid similar situations.
Depression Does Not Predict Clinical Outcome of Chinese Peritoneal Dialysis Patients After Adjusting for the Degree of Frailty
Authors: CHAN Gordon Chun-Kau , NG Jack Kit-Chung , CHOW Kai-Ming , Kwan Bonnie CH , KWONG Vickie Wai-Ki , PANG Wing-Fai , CHENG Phyllis Mei-Shan , LAW Man-Ching , LEUNG Chi-Bon , LI Philip Kam-Tao , Szeto Cheuk Chun
Published: January 2020

Background Depression and frailty contribute to the adverse clinical outcome of peritoneal dialysis (PD) patients. However, the interaction between depression and frailty in PD patients remains uncertain. We determined the prevalence of depression and frailty in prevalent Chinese PD patients, dissected the internal relationship between depression and frailty, and determined their relative contribution to the adverse clinical outcome in PD patients. Methods In a prospective observational study, we recruited 267 prevalent PD patients. Depression was identified by Patient Health Questionnaire (PHQ-9). Frailty was identified by a validated Frailty Score. All cases were followed for one year. Outcome measures included number and duration of hospitalization, peritonitis rate, and all-cause mortality. Results Of the 267 patients, 197 patients (73.8%) were depressed, and 157 (58.8%) were frail. There was a substantial overlap between depression and frailty. Although depression and frailty were associated the number and duration of hospitalization by univariate analysis, the association became insignificant after adjusting for confounding factors by multivariate analysis. Both depression and frailty were associated with one-year mortality by univariate analysis. One-year patient survival was 95.9%, 86.5%, 82.4% and 71.0% for patients with nil, mild, moderate and severe frailty, respectively (p = 0.001). Frailty was an independent predictor of patient survival by multivariate analysis (adjusted hazard ratio 1.424, 95% confidence interval 1.011-2.005. p = 0.043), while the prognostic effect of depression disappears after adjusting for frailty score. Conclusion Depression and frailty were common among Chinese PD patients. Frailty, but not depression, was an independent predictor of one-year mortality.
Screen time and eating during screen time: associations with dietary intake in children and adolescents
Authors: Jensen Melissa L , Carpentier Francesca Dillman , Corvalán Camila , Popkin Barry M. , Evenson Kelly , Adair Linda , Taillie Lindsey Smith
Published: January 2020

Background: Increased TV viewing is associated with overweight and obesity in children and adolescents. Excess weight gain might be a result of increased dietary intake during television viewing, eating foods that are highly advertised at other times, or lack of physical activity. The objectives of this cross-sectional study were (1) to determine the extent of screen time and eating during screen time, and the correlation between these two different exposures, (2) to compare food and nutrient consumption of on- versus off-screen eating occasions, and (3) to determine whether screen time and eating during screen time is associated with overall dietary intake.
Methods: Participants were part of the Food Environment Chilean Cohort (FEChiC, n=938, 4-6 y) and the Growth and Obesity Cohort Study (GOCS, n=752, 12-14 y), recruited in the southeast region of Santiago, Chile in 2016. Dietary data was collected via 24-h food recalls. For each eating occasion, participants or their primary caregiver reported activity performed during consumption. Analyses included Spearman correlations, multivariable linear regression models and logistic regression. For daily consumption analyses, post-hoc pairwise comparisons examined differences in our main outcomes by tertiles.
Results: In our sample, 87.5% reported consuming at least one meal or snack per day while on a screen. The median kilocalories contributed by eating during screen time was 387 kcal/d in children and 848 kcal/day in adolescents, which represents 34.7% and 42.3% of daily energy intake, respectively. There were no consistent differences in the nutrient profile or food groups consumed for either age group when comparing eating occasions consumed on-screen versus off-screen. Daily consumption analyses revealed that higher weekly hours of TV viewing was associated with elements of a less healthy diet including more sweets and desserts in children, and more sugar sweetened beverages in adolescents.
Conclusions: A large percentage of children and adolescents’ daily energy intake is consumed while watching television or on their phone. In depth, longitudinal work is needed to understand how screen time eating affects diet quality and nutritional status.
Efficacy of Different Recruitment Maneuvers for Improved Lung Inhomogeneity in a Pig Model of ARDS
Authors: Xia Feiping , Pan Chun , Wang Lihui , Liu Ling , Liu Songqiao , Guo Fengmei , Yang Yi , Huang Yingzi
Published: January 2020

Background: In acute respiratory distress syndrome (ARDS), lung recruitment maneuvers can recruit collapsed alveoli in gravity-dependent lung regions, improving the homogeneity of ventilation distribution. This study used electrical impedance tomography (EIT) to investigate the efficacy of different recruitment maneuvers for alveolar recruitment in a pig model of ARDS. Methods: ARDS was induced in ten healthy male pigs with repeated bronchoalveolar lavage until the arterial partial pressure of oxygen (PaO 2 )/fraction of inspired oxygen (FiO 2 ) (P/F ratio) was < 100 mmHg and remained stable for 30 minutes (TARDS). ARDS pigs underwent three sequential recruitment maneuvers, including sustained inflation (SI), increments of positive end-expiratory pressure (PEEP) (IP), and pressure-controlled ventilation (PCV) applied in random order, with 30 mins at a PEEP of 5 cmH 2 O between maneuvers. Respiratory mechanics, hemodynamics, arterial blood gas, and EIT were recorded at baseline, TARDS, and before and after each recruitment maneuver.Results: In all ten pigs, ARDS was successfully induced with a mean 2.8±1.03 (2800±1032.80ml) bronchoalveolar lavages. PaO 2 , SO 2 , P/F, and compliance were significantly improved after recruitment with SI, IP or PCV (all p<0.05), and there were no significant differences between maneuvers. Global inhomogeneity (GI) was significantly decreased after recruitment with SI, IP, or PCV. There were no significant differences in GI before or after recruitment with the different maneuvers. The decrease in GI (ΔGI) was significantly greater after recruitment with IP compared to SI (p=0.023), but there was no significant difference in ΔGI between IP and PCV. Conclusion: SI, IP, and PCV increased oxygenation, regional compliance and lung compliance, and decreased inhomogeneous gas distribution with no adverse effects on hemodynamics in ARDS pigs. IP significantly improved inhomogeneity of the lung compared to SI.
The efficacy and safety of intrathecal bupivacaine alone versus bupivacaine combined with magnesium sulfate in adults using spinal anesthesia: a meta-analysis of randomized controlled trials
Authors: Wang Mi-Zhou , Dong Rui , Jia Li-Na , Ai Deng-Bin , Zhang Jian-Hua
Published: January 2020

Background: Several studies have investigated the effects of intrathecal magnesium sulfate as an adjuvant for bupivacaine; however, their conclusions are inconsistent. Therefore, it is necessary to conduct a meta-analysis on this topic.Methods We searched Pubmed, EMBASE (OvidSP) and Cochrane Central Register of Controlled Trials (CENTRAL) for randomized controlled trials (RCTs) comparing the effect of intrathecal bupivacaine combined with magnesium sulfate versus bupivacaine alone in adults using spinal anesthesia.Results Eighteen studies that met our inclusion criteria were included in our analysis. We found that the addition of intrathecal magnesium sulfate to bupivacaine provided a longer duration of analgesia (SMD 0.99; 95% CI [0.45, 1.52], P = 0.0003, I2 = 93%), prolonged the duration of sensory block (MD=106.69; 95% CI, 60.93-152.45; P<0.00001), delayed the onset of sensory block (SMD 1.20; 95% CI [0.65, 1.75], P =<0.0001, I2 = 91%) and motor block (SMD 1.46; 95% CI [0.23, 2.69], P =0.02, I2 = 96%), decreased the requirement for rescue analgesia (SMD -0.81; 95% CI [-1.06, -0.56], P < 0.00001, I2 = 11%). For duration of motor block, and incidence of postoperative adverse events (such as nausea and vomiting, hypotension, bradycardia, pruritus, shivering and neurological deficit), no statistically differences were observed between the 2 groups.Conclusions Our meta-analysis demonstrated that intrathecal magnesium sulfate combined with bupivacaine prolongs the dusration of analgesia, without an impact on the adverse events. However, the quality of evidence was very low when using GRADE to assess it. Given adverse effects before use, more high-quality trials with large samples are required before magnesium sulfate is routinely used as a intrathecal adjunct.
Troponin I as a mortality marker after lung resection surgery – a prospective cohort study.
Authors: Uchoa Ricardo , Caramelli Bruno
Published: January 2020

Background: Cardiovascular complications associated with thoracic surgery increase morbidity, mortality, and treatment costs. Elevated cardiac troponin level represents a predictor of complications after non-cardiac surgeries, but its role after thoracic surgeries remains undetermined. The objective of this study was to analyze the relationship between troponin I elevation and morbidity and mortality after one year in patients undergoing lung resection surgery. Methods : This prospective cohort study evaluated 151 consecutive patients subjected to elective lung resection procedures using conventional and video-assisted thoracoscopic techniques at a University Hospital in Brazil, from July 2012 to November 2015. Preoperative risk stratification was performed using the scores obtained by the American College of Physicians (ACP) and the Society of Cardiology of the state of São Paulo (EMAPO) scoring systems. Troponin I levels were measured in the immediate postoperative period (POi) and on the first and second postoperative days. Results : Most patients had a low risk for complications according to the ACP (96.7%) and EMAPO (82.8%) scores. Approximately 49% of the patients exhibited increased troponin I (≥0.16 ng/ml), at least once. Multivariate analysis showed that the elevation of troponin I, on the first postoperative day, correlated with a 12-fold increase in mortality risk within one year (HR 12.02, 95% CI: 1.82-79.5; p=0.01). Conclusions : In patients undergoing lung resection surgery, with a low risk of complications according to the preoperative evaluation scores, an increase in troponin I levels above 0.16 ng/ml in the first postoperative period correlated with an increase in mortality within one year. Keywords: Troponin, non-cardiac surgery, thoracic surgery, cardiovascular complications, cardiovascular risk, perioperative care.
Long-term, in toto live imaging of the developing mouse heart
Authors: Yue Yanzhu , Li Xin , Zhang Youdong , He Aibin
Published: January 2020

Mapping holistic cell behaviors sculpting mammalian heart has been a goal, but so far only successes in transparent invertebrates and lower vertebrates. Using a live-imaging system comprising a customized vertical light-sheet microscope equipped with a culture module, a heartbeat-gated imaging strategy, and a digital image processing framework, we realized imaging of developing mouse hearts with uninterrupted cell lineages for up to 1.5 days. Four-dimensional landscapes of cell behaviors revealed a blueprint for ventricle chamber formation in which biased outward migration of outermost cardiomyocytes coupled with cell intercalation and horizontal division. The trabeculae, an inner muscle architecture, was developed through early fate segregation and transmural cell arrangement involving both oriented cell division and directional migration. Thus, live-imaging reconstruction affords a transformative means for deciphering mammalian organogenesis.
Developing smart Tele-ECG system for early detection and monitoring heart diseases based on ECG signal: progress and challenges
Authors: Jatmiko Wisnu , Ma’sum M. Anwar , Wisesa Hanif Arief , Sanabila Hadaiq Rolis
Published: January 2020

Technology is developed to benefit society. One of the applications of technology in the healthcare sector is telehealth monitoring system. The system proposes a new way of communication between the doctor and the patient, even in a very remote location. In this paper, we elaborate the progress and challenges regarding the development of Tele-ECG in Indonesia, which includes data acquisition, feature extraction, data compression, classification algorithm, mobile and web development system and small device implementation on an FPGA board. The classification is conducted by using LVQ, GLVQ, FNLVQ, FNLVQ-PSO, FNGLVQ, and AM-GLVQ. The compression is conducted by using SPIHT algorithm. Tele-ECG can assist in monitoring heartbeat anomalies and reduce the risk of heart attack. It could also be a solution for infrastructure discrepancy in healthcare.
Features of the protection of the rights of doctors — anesthesiologist-reanimatologists at the stage of a preliminary consequence. Federation of anaesthesiologists and reanimatologists legal committee information
Authors: Unzhakov V. V. , Gorbachev Vladimir I.
Published: January 2020

The article discusses the concept of the degree of guilt in the actions of a physician — anesthesiologist and resuscitator with philosophical and legal approaches. An example is a rational approach to the examination in determining the guilt of a doctor in the event of a critical condition in a patient.
New criteria for sepsis-induced coagulopathy. Review
Authors: Sinkov Sergey V. , Roitman E. V. , Zabolotskikh I. B.
Published: January 2020

In 2017 a new criteria for sepsis-induced coagulopathy (SIC) were issued following the revised sepsis definition in 2016. They aimed to the earliest detection of the sepsis-specific thrombotic phenotype of disseminated intravascular coagulation (DIC) in order to improve outcomes with early anticoagulant treatment in critically ill patients with sepsis. The following validation of SIC score demonstrated higher forecast value of that and revealed higher correlation with mortality compared to DIC score by the International Society on Thrombosis and Haemostasis (ISTH).
In the future the ISTH plans to offer a simplified two-step scoring system for early DIC syndrome revealing in which SIC scale is as the first step, and the next step is the assessing of overt-DIC in patients who meet the criteria of SIC. The main goal of that should become the opportunity of timely therapeutic effects to the hemocoagulation in order to improve the treatment effectiveness of a sepsis.
Efficacy and safety of retrobulbar blockade with ropivacaine during selective intraarterial chemotherapy in children with retinoblastoma. Article
Authors: Belousova E. I. , Matinyan Nune V. , Martynov L. A. , Letyagin I. A. , Ushakova T. L. , Polyakov V. G.
Published: January 2020

Background. The goal of treatment of retinoblastoma is not only the preservation of life and vision, but also the minimization of systemic complications, a cosmetic defect, which is achieved through the development of selective intraarterial chemotherapy (SIACT). Repeated conduction of the SIACT at the time of catheterization a. ophtalmica is accompanied by cardio-respiratory disorders (CRD).
Objectives. We analyze the effectiveness and safety of retrobulbar blockade with a 0.,5 % solution of ropivacaine to prevent or reduce CRD.
Materials and methods. The study included patients from the Blokhin National Medical Research Center of Oncology with retinoblastoma under conditions of general anesthesia in 2017–2018 SIACT procedures were performed (n = 267). 83 patients were primary. 83 % of them had a mild and moderate degree of cardio-respiratory disorders during the second SIAHT procedure, 17 % of patients who were included in the study developed marked CRD (n = 14), for the prevention of which, during the third procedure of SIACT was performed retrobulbar blockade (RBB).
Results. 4 (28.57 %) patients after retrobulbar blockade did not develop CRD in the third SIACT procedure, in 5 (35.7 %) patients after performing RBB, CRD symptoms decreased to moderate and in 5 (35.7 %) mild expressiveness. After the RBB, there was a lesser increase in airway resistance during inhalation of Pinsp 25.4 ± 7.4, versus 33.8 ± 3.2 with OA and more stable hemodynamics. When conducting retrobulbar blockade with a solution of ropivacaine 0.5 % with a volume of up to 1.5 ml, no complications were observed in children with retinoblastoma. Conclusion. In our experience, pronounced cardio-respiratory complications are often observed during repeated sessions of SIACТ in children with retinoblastoma and can be potentially life-threatening. Using of retrobulbar blockade with severe CRD may reduce the frequency and degree of development of respiratory disorders and is accompanied by greater hemodynamic stability.
Objectification of the prognosis of postoperative outcomes in abdominal surgery of the newborn. Article
Authors: Budarova K. V. , Shmakov Aleksej N. , Elizarʼeva N. L. , Kokhno V. N.
Published: January 2020

Background. Predicting outcomes in infants with surgical bowel disease based on routinely monitored indicators is an unresolved problem.
Objectives. To create a predicting model of the probability of survival in newborns with surgical pathology of the intestine by using the method of logistic regression.
Material and methods. The study involved 77 newborns with acute gastrointestinal pathology. All patients were divided into two groups according to the outcome. Analyzed parameters: gestational age, birth weight, dynamic evaluation of multiple organ failure at the study stages. Ranging of predictors is done using the Forward method. The predicting model is developed by the method of logistic regression. A critical level of significance is p < 0.05.
Results. High rates of gestational age (p = 0.002) and assessment of multi-organ failure on the NEOMOD scale at stage 3 (p = 0.000) had high predictive power. Body weight at birth did not show a significant effect on outcome.
Conclusions. The outcome predicting in neonatal surgery is possible at the stage of short-term prognosis. Independent significant predictors are the duration of gestation and the severity of multiple organ failure in newborns.
Prevention, the algorithm of reference, anesthesia and intensive care for postpartum hemorrhage. Guidelines
Authors: Shifman E. M. , Kulikov A. V. , Ronenson Alexander M. , Abazova I. S. , Adamyan L. V. , Andreeva M. D. , Artymuk N. V. , Baev O. R. , Barinov S. V. , Belokrinitskaya T. E. , Blauman S. I. , Bratishchev I. V. , Bukhtin A. A. , Vartanov V. Y. , Volkov A. B. , Gorokhovskiy V. S. , Dolgushina N. V. , Drobinskaya A. N. , Kinzhalova S. V. , Kitiashvili I. Z. , Kogan I. Yu. , Korolev A. Yu. , Krasnopolskii V. I. , Kukarskaya I. I. , Kurcer M. A. , Marshalov D. V. , Matkovskiy A. A. , Ovezov A. M. , Penzhoyan G. A. , Pestrikova T. Yu. , Petruhin V. A. , Prihodko A. M. , Protopopova N. V. , Protsenko D. N. , Pyregov A. V. , Raspopin Yu. S. , Rogachevskiy O. V. , Ryazanova O. V. , Savelyeva G. M. , Semenov Yu. A. , Sitkin S. I. , Fatkullin I. F. , Fedorova T. A. , Filippov O. S. , Shvechkova M. V. , Shmakov R. G. , Shchegolev A. V. , Zabolotskikh I. B.
Published: January 2020

The article observes the main provisions of the clinical recommendations for prevention, anesthesia and intensive care for postpartum hemorrhage. The main risk factors, possible complications, principles of clinical and laboratory diagnosis in this pathology are consistently presented. Particular attention is paid to issues of infusion, transfusion therapy and correction of coagulopathic disorders. The problems of estimating the amount of blood loss, diagnosing disorders of the hemostatic system, regulation of hemodynamics in hemorrhagic shock are discussed. The use of recombinant coagulation factors in coagulopathy on the background of massive blood loss has been substantiated.
Finding the derivative price using the Vasicek model with multidimensional stochastic volatility
Authors: Burtnyak Ivan , Malytska Anna
Published: January 2020

Methods of calculating the approximate price of options using instruments of spectral analysis, singular and regular wave theory in the context of influence of fast and slow acting factors are developed. By combining methods from the spectral theory of singular and regular disturbances, one can approximate the price of derivative financial instruments as a schedule of its own functions. The article uses the theory of spectral analysis and the singular and regular theory of perturbations, which are applied to the short-term interest rates described by the Vasicek model with multidimensional stochastic volatility. The approximate price of derivatives and their profitability are calculated. Applying the Sturm-Liouville theory, the Fredholm alternative, and the analysis of singular and regular disturbances in different time scales, explicit formulas were obtained for the approximation of bond prices and yields based on the development of their own functions and eigenvalues of self-adjoint operators using boundary value problems for singular and regular perturbations. The theorem for estimating the accuracy of derivatives price approximation is established. Such a technique, in contrast to existing ones, makes it possible to study the stock market dynamics and to monitor the financial flows in the market. This greatly facilitates the statistical evaluation of their parameters in the process of monitoring the derivatives pricing and the study of volatility behavior for the profitability analysis and taking strategic management decisions on the stock market transactions.
The case of prenatal ultrasound diagnosis of isolate bilateral anophthalmia
Authors: E.L. Kucheva, E.V. Potolova, E.I. Kopytova
Published: January 2020

The case of prenatal ultrasound diagnosis of isolate bilateral anophthalmia at 19–20 weeks of gestation is
presented. The pregnancy was terminated, the diagnosis was confirmed. The incidence of this rare fetus pathology
at Sverdlovsk region during last 10 years and combination with other defect and chromosome anomalies is
analyzed. Possibility of early detection of eyes pathology and necessity of genetic consulting of patients with
burdened familial history are discussed.
Определение структуры децеллюляризированных дермальных матриксов
Authors: Камышинский Р. А. , Антипова К. Г. , Куевда Е. В. , Кузнецова Д. М. , Пацаев Т. Д. , Мороков Е. С. , Храмцова Е. А. , Алейник Д. Я. , Егорихина М. Н. , Григорьев Т. Е. , Губарева Е. А. , Васильев А. Л.
Published: January 2020

Одним из важнейших аспектов регенеративной медицины является подбор матрикса — биологического каркаса тканеинженерной конструкции. Для наилучшей воспроизводимости структуры и свойств поврежденной ткани, а также поддержания клеточной адгезии и пролиферации оптимальным является использование матриксов, полученных при децеллюляризации нативных органов с последующей рецеллюляризацией различными клеточными линиями. Методами растровой электронной микроскопии в режиме естественной среды и сканирующей импульсной ультразвуковой микроскопии определена микроструктура нативных и децеллюляризированных матриксов дермальных тканей.
Optimization of the sorption of selected polycyclic aromatic hydrocarbons by regenerable graphene wool
Authors: Adeola Adedapo O. , Forbes Patricia B. C.
Published: January 2020

A novel graphene wool (GW) material was used as adsorbent for the removal of phenanthrene (PHEN) and pyrene (PYR) from aqueous solution. Adsorption kinetics, adsorption isotherms, thermodynamics of adsorption and effect of pH, ionic strength, and temperature on the adsorption of PHEN and PYR onto GW were comprehensively investigated. Isothermal and kinetic experimental data were fitted to Langmuir, Freundlich, Temkin, Sips and Dubinin–Radushkevich models, as well as pseudo-first-order and pseudo-second-order kinetic models. The adsorption kinetic data best fit the pseudo-second-order kinetic model for PHEN and PYR sorption with R2 value >0.999, whilst the Sips model best fit isotherm data. Kinetic data revealed that 24 hr of contact between adsorbent and polycyclic aromatic hydrocarbons (PAHs) was sufficient for maximum adsorption, where the Langmuir maximum adsorption capacity of GW for PHEN and PYR was 5 and 20 mg g−1 and the optimum removal efficiency was 99.9% and 99.1%, respectively. Thermodynamic experiments revealed that adsorption processes were endothermic and spontaneous. Desorption experiments indicated that irreversible sorption occurred with a hysteresis index greater that zero for both PAHs. The high adsorption capacity and potential reusability of GW makes it a very attractive material for removal of hydrophobic organic micro-pollutants from water.
Combinatorial Synthesis of Novel 9R-Acyloxyquinine Derivatives as Insecticidal Agents
Authors: Che Zhiping , Yang Jinming , Sun Di , Tian Yuee , Liu Shengming , Lin Xiaomin , Jiang Jia , Chen Genqiang
Published: January 2020

Background:

It is one of the effective ways for pesticide innovation to develop new
insecticides from natural products as lead compounds. Quinine, the main alkaloid in the bark of
cinchona tree as well as in plants in the same genus, is recognized as a safe and potent botanical
insecticide to many insects. The structural modification of quinine into 9R-acyloxyquinine
derivatives is a potential approach for the development of novel insecticides, which showed more
toxicity than quinine. However, there are no reports on the insecticidal activity of 9Racyloxyquinine
derivatives to control Mythimna separata.

Methods:

Endeavor to discover biorational natural products-based insecticides, 20 novel 9Racyloxyquinine
derivatives were prepared and assessed for their insecticidal activity against M.
separata in vivo by the leaf-dipping method at 1 mg/mL.

Results:

Among all the compounds, especially derivatives 5i, 5k and 5t exhibited the best
insecticidal activity with final mortality rates of 50.0%, 57.1%, and 53.6%, respectively.

Conclusion:

Overall, a free 9-hydroxyl group is not a prerequisite for insecticidal activity and C9-
substitution is well tolerated; modification of out-ring double-bond is acceptable, and
hydrogenation of double-bond enhances insecticidal activity; Quinine ring is essential and open of
it is not acceptable. These preliminary results will pave the way for further modification of quinine
in the development of potential new insecticides.
Exploiting XG Boost for Predicting Enhancer-promoter Interactions
Authors: Yu Xiaojuan , Zhou Jianguo , Zhao Mingming , Yi Chao , Duan Qing , Zhou Wei , Li Jin
Published: January 2020

Background:

Gene expression and disease control are regulated by the interaction
between distal enhancers and proximal promoters, and the study of enhancer promoter interactions
(EPIs) provides insight into the genetic basis of diseases.

Objective:

Although the recent emergence of high-throughput sequencing methods have a
deepened understanding of EPIs, accurate prediction of EPIs still limitations.

Methods:

We have implemented a XGBoost-based approach and introduced two sets of features
(epigenomic and sequence) to predict the interactions between enhancers and promoters in
different cell lines.

Results:

Extensive experimental results show that XGBoost effectively predicts EPIs across three
cell lines, especially when using epigenomic and sequence features.

Conclusion:

XGBoost outperforms other methods, such as random forest, Adadboost, GBDT, and
TargetFinder.
Hepatitis E Genotype 1 Outbreak in Jharkhand, India: A Descriptive Analysis
Authors: Mehta Neelam , Gupta Minakshi , Mishra Minakshi , Singh Santosh Kumar
Published: January 2020

Introduction:

A waterborne outbreak of hepatitis E virus occurred in the Jamshedpur city
of Jharkhand from March 2018 to October 2018. The aim of the present study is to study the hepatitis
E virus outbreak clinically, serologically and etiologically.

Methods:

Five hundred and eighty-four clinically and biochemically documented cases were
screened for the hepatotropic viral markers (HepatitisA, B, C, and E) by the ELISA. Demographic
data such as gender, age, clinical diagnosis, location, outcome and time of admission were extracted
from the online hospital management system. Water samples from the affected area were tested for
HEV RNA detection. Genotyping of HEV virus was carried out by sequencing and phylogenetic
analysis.

Results:

Hepatitis E genotype 1 was confirmed as the major etiological agent in this outbreak due to
the faecal contamination of drinking water supply while establishing illegal water connections.
Mixed infection of HEV-HAV (5.31%) or HEV-HBV (0.91%) was also detected in the present
series of acute viral hepatitis.

Conclusions:

The study highlights the importance of screening for both enterically transmitted hepatotropic
viral markers as well as the parenterally transmitted hepatotropic viral markers during the
outbreaks of acute viral hepatitis.
An Explainatory Study on Cooperative Investment Risk of Joint Venture Companies from an Economics of Organization Perspective
Authors: Dai Hao , Zhang Chaoqi , Yang Xiaojing
Published: January 2020

Background:

Joint investment has increasingly become a popular investment method
for venture capitalists. From the two traditional perspectives of investors and start-ups, research on
Joint Venture Capital in the past 40 years has achieved rich results. Most recent literature is based
on research from the perspective of organisational economics, which further advances the vertical
development of research on Joint Venture Capital.

Objective:

The objective of this paper is to review research topics and core literature on Joint Venture
Capital from the perspective of organisational economics, and through introducing the model
of venture capitalists' ‘bounded rationality’ and evolutionary game in the joint investment risk
analysis. This paper distinguishes the influence of the game model on the formation of joint investment.
Finally, it reaches a conclusion and suggests a direction for future research.

Methods:

This paper finds and reviews literature on joint venture capital and dynamic game model
of joint investment risk that is collated to reduce the actual risk assumed by each investor. Additionally,
the paper summarises research topics and progress from the perspective of organisational
economics to identify possible research directions for the future.

Results:

Based on the evolutionary game method for analysis of the model of joint investment, the
following conclusion is drawn: the greater the heterogeneity of the participating entities, the smaller
the unit conflict cost benefit and the greater the probability of successful joint venture investment.
The joint investment operation mechanism will also be maintained on a long-term and stable
manner.

Conclusion:

From the perspective of organisational economics, the latest research on Joint Venture
Capital has extensively absorbed new research results of relevant disciplines. Joint Venture Capital
activities can be understood from a broader perspective and with new insights, which reflect complex
and dynamic interaction and correlative dependence on network members. To establish a more
successful joint investment model, the paper introduces a relatively novel evolutionary game method
for analysis of the joint investment model.
Synthesis, Characterization and Evaluation of Antioxidant and Antimicrobial activity of Spirochromones Derivatives
Authors: Shinde Achut R. , Muley Dyanoba B.
Published: January 2020

Background:

Plethora of literature reported hitherto, depicts impending biological activities
for spirochromones. This fact encouraged us for the exploration of the synthesis of new
substituted spirochromones and their evaluation of their bioactivities.

Objective:

To synthesize different substituted spirochromones derivatives from a spirochromones salt
using (R)-pyroglutamic acid as catalyst and their evaluation for antimicrobial and antioxidant activities.

Methods:

Herein, Aldol cascade method was used for the syntheses of spirochromone derivatives
from its salt. A mild protocol is developed for the syntheses of spirochromones derivatives by using
(R)-pyroglutamic acid as catalyst. Further, the derivatives and its precursor salt were screened
for antimicrobial and antioxidant activity. The antioxidant potentials of the synthesized compounds
were checked by DPPH and hydroxyl free radical scavenging assay. Consequently, in vitro antimicrobial
activities were performed by well diffusion assay against gram negative bacterium (E.
coli) and gram positive bacterium (S. aureus).

Results:

In the present work, 10 synthesized derivatives are obtained in harmonious yield from a
precursor spirochromones salt using (R)-pyroglutamic acid as catalyst. Amongst the studied compounds,
6a depicted maximum antimicrobial activity against the screened microorganisms along
with maximum antioxidant activity. Albeit, the synthesized motifs showed moderate to good antioxidant
and antimicrobial activities.

Conclusion:

A mild protocol was developed for the synthesis of spirochromone derivatives from
their precursor spirochromones salt by using (R)-pyroglutamic acid as catalyst, which showed
moderate to good antimicrobial and antioxidant activity.
RELATIONSHIP BETWEEN LEVEL OF DISASTER KNOWLEDGE AND ATTITUDE OF LANDSLIDE DISASTER PREPAREDNESS IN VOLUNTEERS "KELURAHAN TANGGUHâ€ IN MALANG CITY
Authors: Rini Ika Setyo , Kristianingrum Niko Dima , Widyastikasari Rizka
Published: January 2020

Indonesia is located between the Eurasian Continent Plate, the Indian-Australian Plate and the Pacific Ocean Plate. It is passed through a series of Mediterranean Circuits and the Pacific Circum. The process of plate and volcanic activity results in natural disasters including landslides. Indonesia has 918 vulnerable location points that are spread in various parts of Indonesia which cause natural disasters in Indonesia to increase every year. BPBD of Malang Citymade a program â€œKelurahan Tangguhâ€ to improve community preparedness against disasters. The purpose of this study was to explore the relationship between landslide disaster preparedness knowledge andattitude on volunteers of â€œKelurahan Tangguhâ€ in KotaLama, Bandungrejosari and Polehan because these three villages experienced the most landslides during 2018. The design of this research is observational correlational analytic with cross sectional research. The research respondents were 39 volunteers in Kotalama, Bandungrejosari and Polehan with a total sampling method. Data were collected using a questionnaire to determine the level of knowledge and attitudes of preparedness. Data analysis used Spearmanâ€™s rank correlation test. The results of the study state that there is a relationship between the level of knowledge and attitudes of preparedness. There is a positive relationship between the level of knowledge with landslide preparedness attitudes (p = 0.000, Î± = 0.05), r = 0.610. There is a undirectional relationship between the level of knowledge and attitudes of preparedness for landslides. Health workers, especially nurses and other professionals can partner with BPBD to actively conduct education, motivation and various training for volunteer empowerment in disaster preparedness in Malang City
Faceless books
Authors: Frias Joana Matos
Published: January 2020

Leitura crítica das obras parque das ruínas, de Marília Garcia, e Manual do Condutor de Máquinas Sombrias, de Rui Pires Cabral (ambas de 2018), com vista a uma problematização dos modos e do valor do vínculo que em ambas se propõe entre a expressão verbal e a impressão fotográfica, muito em particular a de carácter retratístico.
O retrato em ruínas e o corpo que nos olha
Authors: Serra Filomena
Published: January 2020

Este artigo discute a pintura Olympia de Édouard Manet e a cópia pintada por Guilherme de Santa-Rita, apresentada na exposição da Academia de Belas-Artes, inaugurada em 18 de Março de 1911, entendendo que esse trabalho deve ocupar um lugar significativo na historiografia da arte em Portugal, sobretudo para a história do modernismo português nas artes plásticas. O artigo destaca a recepção dessa cópia apresentada naquela exposição, precisamente no dia anterior à Exposição Livre de 1911.

A Olympia de Santa-Rita, hoje lamentavelmente esquecida, questionou a pintura e o género do retrato em Portugal, a sua relação com o corpo logo no início do século, quando não toda a hipocrisia de uma sociedade. Relembrá-la é fundamental para a história da arte do retrato em Portugal.
Теплопроводность твердых растворов Cu-=SUB=-2-=/SUB=-ZnGe-=SUB=-1-x-=/SUB=-Sn-=SUB=-x-=/SUB=-Se-=SUB=-4-=/SUB=-
Authors: Боднарь И.В.
Published: January 2020

Abstract Cu_2ZnGeSe_4 and Cu_2ZnSnSe_4 and Cu_2ZnGe_1 –_ x Sn_ x Se_4-alloy crystals are grown by the Bridgman method (vertical variant). The composition and structure of the crystals are determined. It is established that both the initial compounds and their alloys crystalize with the formation of tetragonal structure. The unit-cell parameters a and c of the crystals are calculated, and the dependences of these parameters on the composition of the alloys are constructed. It is shown that, under variations in the composition parameter x , the parameters a and c vary in accordance with Vegard’s law. The thermal conductivity of the Cu_2ZnGeSe_4 and Cu_2ZnSnSe_4 compounds and Cu_2ZnGe_1 –_ x Sn_ x Se_4 alloys is measured in the temperature range 300–600 K. It is found that the thermal conductivity varies with x , with a minimum for the medium composition.