bluuebunny/crossref_metadata_2025 huggingface dataset:
A Bioinformatics Investigation of Hub Genes Involved in Treg Migration and Its Synergistic Effects, Using Immune Checkpoint Inhibitors for Immunotherapies
Authors: Kim Nari , Na Seoungwon , Pyo Junhee , Jang Jisung , Lee Soo-Min , Kim Kyungwon
Published: August 2024

This study aimed to identify hub genes involved in regulatory T cell (Treg) function and migration, offering insights into potential therapeutic targets for cancer immunotherapy. We performed a comprehensive bioinformatics analysis using three gene expression microarray datasets from the GEO database. Differentially expressed genes (DEGs) were identified to pathway enrichment analysis to explore their functional roles and potential pathways. A protein-protein interaction network was constructed to identify hub genes critical for Treg activity. We further evaluated the co-expression of these hub genes with immune checkpoint proteins (PD-1, PD-L1, CTLA4) and assessed their prognostic significance. Through this comprehensive analysis, we identified CCR8 as a key player in Treg migration and explored its potential synergistic effects with ICIs. Our findings suggest that CCR8-targeted therapies could enhance cancer immunotherapy outcomes, with breast invasive carcinoma (BRCA) emerging as a promising indication for combination therapy. This study highlights the potential of CCR8 as a biomarker and therapeutic target, contributing to the development of targeted cancer treatment strategies.
Durability of Magnesium Potassium Phosphate Cements (MKPCs) under Chemical Attack
Authors: Chhaiba Salma , Martinez-Sanchez Sergio , Husillos-Rodriguez Nuria , Palomo Ángel , Kinoshita Hajime , Garcia-Lodeiro Inés
Published: August 2024

Magnesium phosphate cements (MPCs), also known as chemically bonded ceramics, represent a class of inorganic cements that have garnered considerable interest in recent years for their exceptional properties and diverse applications in the construction and engineering sectors. However, the development of these cements is relatively recent (they emerged at the beginning of the 20th century), so there are still certain aspects relating to their durability that need to be evaluated. The present work analyses the chemical durability of magnesium potassium phosphate cements (MKPCs) during 1 year of immersion in three leaching media: seawater, a Na2SO4 solution (4% by mass) and deionized water. For this, pastes of prismatic specimens of MKPC, prepared with different M/P ratio (2 and 3), were submitted to the different chemical attacks. At different ages, the changes on the mechanical strengths, microstructure (BSEM, MIP) and mineralogy (XRD, FTIR, TG/DTG) were evaluated. The results obtained indicate that, in general terms, MKPC systems show good behavior in the three media, with the more resistant system being the one prepared with a M/P molar ratio of 3.
Streamlining YOLOv7 for Rapid and Accurate Detection of Rapeseed Varieties on Embedded Device
Authors: Gu Siqi , Meng Wei , Sun Guodong
Published: August 2024

Real-time seed detection on resource-constrained embedded devices is essential for the agriculture industry and crop yield. However, traditional seed variety detection methods either suffer from low accuracy or cannot directly run on embedded devices with desirable real-time performance. In this paper, we focus on the detection of rapeseed varieties and design a dual-dimensional (spatial and channel) pruning method to lighten the YOLOv7 (a popular object detection model based on deep learning). We design experiments to prove the effectiveness of the spatial dimension pruning strategy. And after evaluating three different channel pruning methods, we select the custom ratio layer-by-layer pruning, which offers the best performance for the model. The results show that using custom ratio layer-by-layer pruning can achieve the best model performance. Compared to the YOLOv7 model, this approach results in mAP increasing from 96.68% to 96.89%, the number of parameters reducing from 36.5 M to 9.19 M, and the inference time per image on the Raspberry Pi 4B reducing from 4.48 s to 1.18 s. Overall, our model is suitable for deployment on embedded devices and can perform real-time detection tasks accurately and efficiently in various application scenarios.
Strategies to Exclude: Temporariness and Return/Readmission Policies of the EU
Authors: Samuk Şahizer , Ince-Beqo Gül , Hennebry Jenna L.
Published: August 2024

Migration governance, migration management and migration crises have been key themes among migration scholars and governments over the last decade. Historically, systemic political economic crises are accompanied by the scapegoating of migrants, often as a strategy to shift the focus away from political and economic decisions taken by states. The EU has been no exception, and political and social tensions around migration are arguably at an all-time high, as European governments aim to protect their interests and manage their borders amidst increasing migration pressures globally. In this paper, we will examine these three EU immigration prevention strategies, with a focus on the recently adopted Pact on Migration and Asylum. Specifically, we ask the following research question: what are the roles of temporariness and return/readmission as important EU strategies to hinder, stop, and exclude the movement of migrants to EU (and Schengen)?
Developing Accurate Repetition Prediction Equations for Trained Older Adults with Osteopenia
Authors: Beia Rose , Wassermann Alfred , Raps Sebastian , Mayhew Jerry , Uder Michael , Kemmler Wolfgang
Published: August 2024

The aim of this study was to evaluate prediction equations to estimate 1RM in different exercises in older men and women with osteopenia/osteoporosis. Forty well-trained older women and men (73 ± 8 years) with osteopenia/osteoporosis performed 1RM dynamic and isometric maximum strength tests on resistance devices. In addition, each participant performed repetitions-to-fatigue (RTF) in the 5–8RM, 9–12RM, and 13–16RM zones. After evaluating the predictive performance of available 1RM prediction equations from the literature, new prediction equations were developed for all seven exercises. One of the available equations that focus on postmenopausal women already acceptably predicted 1RM from RTF for all but one exercise. Nevertheless, new exercise-specific prediction equations based on a cubic polynomial most accurately predict 1RM from RTF in the 5–8 reps range with mean absolute differences between predicted and actual 1RM of 3.7 ± 3.7% (leg-press) to 6.9 ± 5.5% (leg flexion) that is roughly within the acceptable coefficient of variation. For some exercises, the inclusion of the isometric maximum strength tests slightly increases the prediction performance of the 5–8RM. In conclusion, the present prediction equation accurately estimates 1RM in trained, older women and men with osteopenia/osteoporosis. Further evaluation of this new equation is warranted to determine its applicability to different age groups and populations.
Central and Peripheral Nervous System Manifestations Associated with Dengue Illness
Authors: Guzman Maria G. , Martinez Eric
Published: August 2024

Dengue illness, caused by the dengue viruses, continues to be a major global health concern, with increasing incidence and the emergence of severe manifestations such as neurological complications. An overview of the current understanding of dengue epidemiology, clinical manifestations, and research priorities is presented here. Dengue transmission has escalated in recent years, exacerbated by factors such as vector expansion, climate change, and socioeconomic challenges. The clinical spectrum of dengue ranges from mild febrile illness to severe manifestations, including hemorrhagic fever and neurological complications. Neurological manifestations of dengue, once considered rare, are now increasingly reported, encompassing encephalitis, myelitis, and Guillain–Barré Syndrome, among others. Diagnosis primarily relies on laboratory methods such as RT/PCR, NS1 antigen detection, and serological assays. Despite advancements in understanding the dengue pathogenesis, there remains a critical need for effective vaccines, antiviral drugs, improved surveillance methods, predictive models for disease severity, and long-term studies on post-Dengue sequelae. Integrated programs and holistic approaches to dengue control are essential for mitigating its impact. Addressing these research priorities will be pivotal in combating dengue and reducing its global burden.
Pengaruh Insentif terhadap Tingkat Disiplin Kerja Karyawan di PT. Perkebunan Nusantara III (Persero) Medan
Authors: Syahputra Rizaldy , Miftahuddin Miftahuddin , Laili KS Isnaniah
Published: August 2024

This study aims to determine the impact of incentives on the level of employee work discipline at PT. Perkebunan Nusantara III (Persero) in Medan. The research conducted is quantitative, aiming to identify the influence or relationship between independent and dependent variables, the strength of the influence or relationship, and to determine the correlation between independent variables. The study's population consists of 50 individuals, sampled using a saturated sample, and with 50 participants serving as respondents. The research results from the t-test indicate that the calculated t for incentives is 7.418, exceeding the t-table value of 1.677, with a t probability (sig) of 0.000, smaller than the significance threshold of 0.05. This demonstrates that incentives, partially, significantly influence work discipline at PT. Perkebunan Nusantara III Medan. Based on the coefficient of determination, the Adjusted R Square value obtained is 0.524. To ascertain the magnitude of the influence of independent variables on the dependent variable, the coefficient of determination (KD) can be calculated as R2 x 100%, yielding a KD of 52.4%. This suggests that 52.4% of work discipline (dependent variable) can be explained by the incentive variable, while the remaining 47.6% is influenced by other factors not accounted for in this study.
Manajemen Strategi Dalam Upaya Peningkatan Kinerja Guru Melalui Supervisi Akademik
Authors: Karoso Subianto
Published: August 2024

The existence of an educational institution lies in the quality of human resources created by the institution. This study focuses on the strategic management role of school principals to improve the quality of Human Resources (HR) management in an effort to improve teacher performance through academic supervision. This research uses the Systematic Literature Review (SLR) method where researchers review and identify journals in a structured and analyzable manner which is carried out in depth from scientific literature according to the research topic with the aim of increasing understanding regarding the research topic used. As for the literature used to strengthen the results of the analysis, researchers succeeded in identifying 30 articles or journals indexed by Sinta and several others found on Google Scholar related to strategic management in efforts to improve teacher performance through academic supervision carried out by school principals. Thus, from the 30 articles it could be filtered and 8 articles were found that were suitable, and the other 22 articles were excluded. Because this research focuses on strategic management in an effort to improve teacher performance through academic supervision. The results obtained are able to determine the role of the school principal in improving teacher performance through academic supervision.
Pengaruh Customer Relationship Management dan Servicescape Terhadap Kepuasan Konsumen Produk KFC (Studi Kasus Pada SMA St Yoseph Medan)
Authors: Sirait Yosi Irma Liza , Tarigan Eka Dewi Setia
Published: August 2024

This research aims to determine the influence of customer relationship management and servicescape on KFC consumer satisfaction (case study at St Yosep High School, Medan). This research uses quantitative methods. The sample in this study was 81 St Joseph High School students. Data collection was carried out by distributing questionnaires. Data analysis in this study used SPSS 25. The research results show that customer relationship management has a positive effect on KFC consumer satisfaction, this is proven by the t-count value of 2.311, which is significant of 0.022. Servicescape has a positive and significant effect on KFC consumer satisfaction, this is proven by the t value of 5.567 and a significant value of 0.000. customer relationship management and servicescape are simultaneously significant to KFC consumer satisfaction, this is proven by the Fcount value of 114,958 and is significant of 0.000.
Influência da Sonata K.448 de Mozart na extinção da memória do medo no camundongo idoso
Authors: Esteves Vilela Romualda Maria , Da Silva Mariana Mendes , De Faria Rodolfo Souza , Trzesniak Clarissa Maria Ferreira
Published: August 2024

Introdução. A memória é um estado cerebral persistente após estímulos sensoriais, influenciando a atividade neuronal. Experiências aversivas geram memórias que perduram, desencadeando respostas defensivas. Estudos indicam que sonatas de Mozart beneficiam a memória de animais jovens e adultos. No entanto, há escassez de estudos sobre os efeitos dessas sonatas na extinção da memória em animais idosos. Objetivo. Investigar o efeito da sonata K.448 de Mozart na extinção da memória de medo contextual de camundongos machos idosos. Método. Foram utilizados 36 camundongos machos da linhagem C57BL/6J, que foram divididos em três grupos: G1-Mozart (n=12), G2-Ambiente (n=13) e G3-Controle (n=11). Apenas o grupo G1 foi exposto à música; G2 e G3 foram expostos ao som ambiente, por 360 dias. Posteriormente, realizou-se treinamento aversivo com os grupos G1 e G2. No dia 396, foi realizado o teste de extinção, durando cinco dias. Ao 421º dia, ocorreu o teste de recordação. Resultados. No teste de extinção, houve efeito principal nos dias (p=0,035). O contraste de seguimento entre os dias 1 vs. 2 (p<0,001) foi significante, indicando diferença no comportamento de freezing entre esses dias. Já em relação ao teste de recordação, não houve diferença entre os grupos. Conclusão. A exposição à sonata K.448 parece não influenciar significativamente a redução da resposta do medo contextual. No entanto, são oportunos novos estudos para o esclarecimento do efeito da música na extinção da memória do medo em camundongos idosos.
Tratamento endoscópico da neoplasia gástrica precoce por dissecção endoscópica da submucosa: análise da eficácia e segurança
Authors: Haurani Carolina Louise Bueno , Bergamaschi Eduardo Zanetti , Ivano Flávio Heuta , Bez Giulia Regina Colaço , Dias Júlia Formes , Porto Letícia Fernandes de Souza
Published: August 2024

Introdução: O câncer gástrico é muito frequente no Brasil e o segundo que mais causa mortes no mundo. A ressecção endoscópica da mucosa (EMR) ou dissecção endoscópica da submucosa (ESD) possibilita o tratamento precoce. Lesões precoces incluem adenocarcinoma restrito a mucosa ou submucosa, independentemente do acometimento linfonodal. ESD é indicada para adenocarcinomas diferenciados com diâmetro > 2cm, não ulcerados e profundidade de invasão T1a, ou adenocarcinomas diferenciados ≤ 3cm, com profundidade T1a e ulceração. Complicações principais são sangramento e perfuração, geralmente tratáveis endoscopicamente. A ESD ainda é pouco difundida, necessitando avaliação da segurança e eficácia para ampla implementação. Objetivo: Avaliar a segurança e eficácia da ESD no tratamento de câncer gástrico precoce, analisando margens de ressecção e índice de complicações. Métodos: Aprovado pelo Comitê de Ética, utilizou-se o prontuário Tasy do Hospital Sugisawa para coleta e análise estatística. Foram incluídos pacientes com câncer gástrico precoce, displasia de alto grau ou tumores neuroendócrinos, submetidos à ESD entre janeiro de 2012 e janeiro de 2023. Resultados: Incluídos 28 pacientes com média de 66,8 anos. A localização predominante foi o antro gástrico (64,3%) e o tamanho médio foi 19,4mm. A taxa de intercorrências intraoperatórias foi 28,6% e pós-operatórias 14,3%. Dois casos tiveram margens comprometidas (7,7%). A idade foi associada a intercorrências pós-operatórias (p=0,027), com média de 76,8 anos. Lesões com margens comprometidas tinham tamanho médio de 37,5mm. Conclusão: A ESD é segura e eficaz para tratar o câncer gástrico precoce, com taxas altas de ressecção completa e baixas de complicações.
UroliftR VS Holep: melhora sintomatológica pós cirúrgica em pacientes com Hiperplasia Prostática benigna
Authors: Bergamaschi Eduardo Zanetti , Grillo Felipe Lopes , Haurani Carolina Louise Bueno , Bez Giulia Regina Colaço , Dias Júlia Formes , Porto Letícia Fernandes de Souza , Meschino Gustavo Soares Paes Giugliano , Bruscato Julia Rosembach , Machado Filho Christiano , Meyer Fernando
Published: August 2024

Justificativa: A hiperplasia prostática benigna é comum em homens, especialmente após os 50 anos. A eficácia dos tratamentos com enucleação da próstata usando Holmium Laser (HoLEP) ou UroliftR na melhoria dos sintomas pós-tratamento ainda é incerta. Objetivo: Comparar a eficácia dos procedimentos cirúrgicos HoLEP e UroliftR na resolução dos sintomas urinários e na satisfação do paciente. Metodologia: Estudo retrospectivo com 35 pacientes de um hospital privado em Curitiba, tratados entre agosto de 2021 e março de 2023. Realizada análise e comparação entre grupos submetidos a HoLEP e UroliftR, para avaliar qual proporcionava uma melhoria mais significativa dos sintomas urinários pré-operatórios e na qualidade de vida dos pacientes. Resultados: A média de idade dos pacientes foi de 67,6 anos, com um volume prostático médio de 63,9 ml. Ambos os procedimentos resultaram em melhorias nos escores de sintomas urinários (IPSS) pós-operatórios. Não houve diferença significativa entre os procedimentos em termos de proporção de pacientes com urgeincontinência ou disfunção erétil. Apenas 16 pacientes do grupo UroliftR tiveram as variáveis de fluxo urinário médio e máximo coletadas, mostrando uma melhora no padrão obstrutivo pós-operatório. Conclusão: Tanto o HoLEP quanto o UroliftR melhoraram a qualidade de vida dos pacientes, sem vantagem significativa de um sobre o outro em termos de disfunção erétil ou urgeincontinência. Além disso, o HoLEP foi preferencialmente usado em pacientes com próstatas maiores.
O uso da lidocaína na prevenção do crescimento tumoral
Authors: Melo Igor de Freitas , Miranda Giovanna de Liz , Corrêa Luísa Santos Barreto , Moura Joana Paula Mendes de , Spagnol Júlia Derzi
Published: August 2024

Introdução: O tratamento das doenças oncológicas é de suma importância na sociedade, uma vez que estas apresentam alta taxa de prevalência na população. As formas de tratamento disponíveis incluem quimioterapia, radioterapia, cirurgia e terapia hormonal, sendo a cirurgia a opção mais associada à cura e à melhor sobrevida. Pacientes, que passam por este procedimento, são submetidos à analgesia, que pode incluir tanto opióides, quanto anestésicos, como a lidocaína, cuja administração reduz o crescimento tumoral e promove a apoptose de células tumorais, favorecendo a sobrevida do paciente. Metodologia: Revisão integrativa da literatura com base em ensaios clínicos randomizados, revisões sistemáticas, revisões literárias, estudos de coorte e caso-controle, de impacto acadêmico e científico. Foram selecionados 11 artigos publicados entre 2018 e 2024. Discussão: O estado inflamatório do corpo, provocado pelos procedimentos cirúrgicos, prejudica a resposta antitumoral do organismo, reduzindo a atividade das células natural killer (NK). A lidocaína demonstra preservar e aumentar a atividade das células NK, além de inibir a aderência e a proliferação das células cancerígenas. Esse anestésico, assim como outros fármacos, inibe os canais de sódio e de cálcio, necessários para a disseminação das células tumorais. Como observado, a infusão da lidocaína diminui, significativamente, a taxa de recorrência dos cânceres colorretal e de mama, mas não apresenta resultado frente ao câncer de pâncreas. Conclusão: Diante de uma doença tão prevalente na população, a administração da lidocaína apresenta resultados positivos para a taxa de sobrevida geral e livre em relação aos cânceres de mama e colorretal. A infusão intraoperatória não apresenta relevância no tratamento do câncer de pâncreas, o que reforça a necessidade de estudos adicionais para determinar a importância da lidocaína no tratamento oncológico.
Cosmetonews - orientações sobre produtos cosméticos para pets
Authors: Barbosa Adrielly dos Santos , Prado Ana Beatriz Costa , Lima Antonio Kassio Silva , Feitoza Jéssica Maruyama , Bemfica Larissa Alvarenga , Rodrigues Mayara da Silva , Souza Rebeca Vitória Rodrigues de , Andrade Vívian Lopes de , Pereira Marcela Monteiro , Paes-Pereira Pâmela , Paes Ellen Regina da Costa , Silva Antonio Batista da
Published: August 2024

No Brasil, mais da metade dos domicílios possuem um animal de estimação. Em 2020, mesmo com a pandemia do novo coronavírus, o mercado pet cresceu em cerca de 13,5%, faturando acima de R$40 bilhões. O país hoje é o terceiro maior mercado pet do mundo, estando atrás apenas dos Estados Unidos e China. A humanização do pet é um dos fatores que auxiliam o crescimento desse mercado. A ausência  de  critérios  e  procedimentos  para  implementação  da cosmetovigilância  veterinária  pela  autoridade  competente,  faz-se necessário investigar junto aos tutores e profissionais da área veterinária a incidência de reações adversas oriundas  do  uso  destes  produtos em cães e  gatos  e  avaliar a  percepção sobre a segurança dos tutores e profissionais em relação a estes produtos. Da  mesma  forma  que  os  humanos,  os  animais  também  podem  apresentar doenças de pele. Uma das doenças de pele mais comuns é a Dermatite atópica (DA), que  ocorrem  em  gatos e cães. O presente projeto  orientou e esclareceu a população sobre o uso seguro de cosméticos  em animais de estimação.
Incidência de dumping precoce e tardio em pacientes pós gastroplastia
Authors: Passos Thiago Carvalho , Vale Leonardo Turquette Lellis do
Published: August 2024

A obesidade é uma condição que está presente em uma grande parcela da população mundial, que desencadeia ou agrava vários problemas de saúde, como hipertensão, diabetes, inflamação crônica e disfunções metabólicas. A cirurgia bariátrica, basicamente consiste em modificações no trato gastro intestinal com redução da cavidade gástrica e dependente da técnica desvio do duodeno e primeiras porções jejunais. A cirurgia acarreta perda da capacidade do estômago reter o alimento até que seja cumprida a primeira etapa da digestão, podendo acarretar chamada de Síndrome de Dumping, um conjunto de sinais e sintomas que ocorrem pela chegada do alimento em macromoléculas no intestino delgado. Este trabalho tem como objetivo avaliar a incidência da Síndrome de Dumping precoce e tardia em pacientes pós gastroplastia. A pesquisa trata-se de um um estudo retrospectivo de coorte, em que sua população é composta por pacientes obesos que já realizaram o procedimento bariátrico e se encontram na fase pós-operatória. A pesquisa será realizada por via telefónica, através de aplicação de questionário. Os dados serão comparados através de gráficos, e em relação às perguntas referente à percepção dos mesmos frente às ações realizadas, serão agrupadas as respostas que forem semelhantes.
Efficacy and Tolerance Evaluation of pbserum smartker Equilibrium Professional
Authors: Arenas Daniel , Svitlana Korkunda , Eloy Soto Andres , López Berroa Jorge , Marín Rivera Daniela
Published: August 2024

Introduction. Skin acts as a complete barrier protecting against external aggressions and keeps the body’s internal balance. The loss of its firmness and elasticity is a complex process associated with cutaneous aging, which implies intrinsic and extrinsic factors that promote changes in the dermis, epidermis, and abnormal pigmentation. In recent years, treatments for improving skin health and beauty have advanced significantly, which has raised great interest in the related technology. Objective. To evaluate the efficacy and tolerability of pbserum smartker Equilibrium Professional in terms of skin firmness and tone improvement, wrinkle reduction, and visible signs of skin aging. Materials and Methods. A non - controlled study was carried out on 22 subjects aged 24 to 70 years old. They had normal and mixed skin with minor imperfections, excluding those with relevant dermatologic pathologies or under specific treatments. Measurements were made by subjective dermatologic evaluation, high - definition photography with the VISIA® device, and non - comedogenicity evaluation. Subjects applied the product once a week for four weeks, and the product was well tolerated with no reported adverse effects. Results. An average improvement of 27 % was observed regarding the unification of skin tone and imperfections after 28 days of use; 77 % of the patients were satisfied, and 63 % were willing to buy the product. The dermatologic evaluation did not find evidence of comedogenicity, high user satisfaction and good product tolerability. Conclusions. A significant improvement was shown in tone unification and skin imperfections, with high satisfaction from the users and a good tolerability of the product.
Oncoguía de cáncer de colon 2023
Authors: López Basave Horacio , Castillo Vega Ángel Omar , Pastor Sifuentes Francisco , Zilli Hernández Stefan , Vela Sarmiento Itzel , Aiello Crocifoglio Vincenzo , Ruiz Molina Juan Manuel , García Herrera Juan Sebastián , Padilla Rosciano Alejandro , Miranda Dévora Gerardo , León Takahashi Alberto Mitsuo , Hernández Castañeda Karla Fabiola
Published: August 2024

Colon cancer is the third leading cause of cancer in Mexico and the world. In Mexico, it is commonly diagnosed in early and locally advanced stages. The main risk factor is lifestyle. Specialists from Instituto Nacional de Cancerología developed Oncoguía de cáncer de colon 2023 [Colon Cancer Guidelines 2023] through consensus work, based on their experience and analysis of the most recent evidence. Herein, risk factors, screening, diagnostic elements (clinical and histological), staging, and treatment (surgery as the cornerstone) are presented in early disease, locally advanced, oligometastatic scenarios, and after conversion therapy. Discussion and multidisciplinary management in decision - making for adjuvant treatment are emphasized.
Penentuan Lokasi Prioritas untuk Pengembangan Pelabuhan Perintis Menggunakan Metode Analytical Hierarchy Process
Authors: Martono Ricky Virona
Published: August 2024

This article discusses the application of the Analytical Hierarchy Process (AHP) method by considering the weight of criteria to determine the best location alternative for pioneer port development in Indonesia. The criteria for choosing the best alternative of ports is based on Government Regulation number 61 / 2009; they are Availability of Port Facilities, Distance to Regional Port, and Economic Growth. The first step is to rank the criteria for all port alternatives based on each port’s current condition. These criteria are given weight relative to each other. This weighting benefits from prioritizing the location of pioneer ports based on the investor's point of view. Priority scores are given based on a comparison of qualitative data for each port, and then they are calculated in the Adjusted Matrix. The results determine the priority location of pioneer ports to be developed first because they are considered to provide the best benefits for development and for investors. On the other hand, other alternative locations that are not a priority do not mean they are rejected for development. To validate the consistency in giving scores, the consistency ratio was calculated, which score is less than one. The result of this article is to give the most priority to Kalimantan Tengah Port, followed by Nusa Tenggara Barat Port and Bangka Belitung Port.
Unveiling the Impact of Audience Involvement, Celebrity Worship, Brand Awareness, and Perceived Product Quality on Purchase and Visit Intentions
Authors: Siahaan Juniarty , Sari Yuca Yolanda , Wijayanti Cynthia Anna
Published: August 2024

The level of popularity of Korean music is in line with the increasing number of K-pop fans in Indonesia. Despite K-Pop's increasing popularity in Indonesia, K-beauty's reputation has declined. This study explores the influence of the Korean wave on consumer behavior in Indonesia, focusing on the K-Pop and K-Beauty industries. The research analyzes the effects of audience involvement, celebrity worship, brand awareness, and perceived product quality on purchase and visit intentions using survey data of 221 K-pop fans. Data were analyzed using Partial Least Squares (PLS). Findings reveal that audience involvement positively influences celebrity worship, which, in turn, boosts brand awareness, and sigficantly impacts perceived product quality. This perceived product quality positively affects consumers' intentions to purchase and visit, highlighting the interconnectedness of these factors. These results underscore the substantial role of audience involvement and celebrity worship in enhancing brand awareness and perceived product quality, which are pivotal in shaping purchase and visit intentions. The study offers valuable insights for businesses and marketers in the K-Pop and K-Beauty industries, emphasizing the need to understand and leverage these dynamics within the Indonesian consumer market.
Pengaruh Konsumsi Air Kelapa Muda Hijau (Cocos Viridis) Terhadap Penurunan Tekanan Darah Pada Penderita Hipertensi
Authors: Nugraha Moch. Didik , Komalasari Mala , Salahudin Rastipiati
Published: August 2024

Latar Belakang: Angka kejadian hipertensi berdasarkan data dari organisasi kesehatan dunia WHO tahun 2023 memperkirakan sebanyak 1,28 miliar orang dewasa berusia 30-79 tahun di seluruh dunia menderita hipertensi. Salah satu pengobatan yang dapat dikonsumsi Masyarakat yaitu pengobatan non farmakologi dengan mengkonsumsi air kelapa muda hijau (Cocos Viridis) yang dianggap sebagai salah satu terapi alternatif mudah untuk menurunkan tekanan darah pada penderita hipertensi. Tujuan penelitian ini adanya pengaruh konsumsi air kelapa muda hijau (Cocos Viridis) terhadap penurunan tekanan darah pada penderita hipertensi. Metode: Jenis penelitian yang digunakan adalah Quasy Eksperimental dengan One Group Pre and Post-test design. Jumlah sampel sebanyak 19 responden dengan teknik Purposive Sampling. Analisis data bivariat menggunakan Uji statistik Wilcoxon Signed Rank Test dan instrumen penelitian yang digunakan dalam penelitian ini Spigmomanometer, SOP pengukuran tekanan darah, SOP pemberian air kelapa muda hijau (Cocos Viridis) dan lembar observasi. Hasil: Nilai rata-rata tekanan darah sistolik sebelum dan sesudah diberikan air kelapa muda hijau (Cocos Viridis) dengan hasil 166,84 mmHg dan 131,37 mmHg dan hasil rata-rata tekanan darah diastolik sebelum dan sesudah diberikan air kelapa muda hijau (Cocos Viridis) dengan hasil 96,89 mmHg dan 77,95 mmHg. Yang artinya keduanya mengalami penurunan. Nilai Bivariat Uji Normalitas Data dengan nilai sig sistolik (Pre) 0,203, Sistolik (Post) 0,030, Diastolik (Pre) 0,107, Diastolik (Post) 0,011 menunjukkan data tidak berdistribusi normal maka peneliti menggunakan uji alternatif uji Wilcoxon Signed Ranks Test. Kesimpulan: Terdapat pengaruh pemberian Air Kelapa Muda Hijau (Cocos Viridis) terhadap penurunan tekanan darah pada penderita hipertensi.
THEORY OF CONSERVATION OF CULTURAL VALUES: TO THE PROBLEM OF CONTRADICTIONS INTERPRETATION
Authors: Макарова Анастасия Сергеевна
Published: August 2024

В статье приводится краткий обзор и анализ сформировавшихся представлений о развитии теории реставрации культурных ценностей. Автор статьи отмечает, что традиционно эволюция теории реставрации представляется как движение от поновления к научной реставрации. При этом эти два основополагающих подхода сосуществуют как в исторической перспективе, так и в актуальной практике. Вероятно, отчасти снять это противоречие возможно, рассмотрев теорию реставрации в свете аксиологической концепции культуры, которая позволяет представить культуру как совокупность ценностных ориентиров. Целью реставрационных работ в этом случае можно назвать актуализацию ценностных критериев объекта реставрации, а задачами - поиск методов ее достижения.

The article provides a brief overview and analysis of the theory of restoration of cultural values. The author notes that traditionally evolution of the theory of conservation is presented as a movement from renovation to scientific restoration. Moreover, these two fundamental approaches coexist both in a historical perspective and in actual practice. Probably, it is possible to partially remove this contradiction by viewing the theory of conservation in the light of the axiological theory of culture, which allows us to present culture as a set of value orientations. The goal of conservation in this case can be in actualization of the value criteria of the object, and the tasks in the search for methods of achieving it.
RESEARCH OF OLD RUSSIAN FURNITUREIN THE FIRST HALF OF THE TWENTIETH CENTURY. TO THE QUESTION OF HISTORIOGRAPHY
Authors: Углева Наталья Владимировна
Published: August 2024

Начало и развитие изучения древнерусской мебели приходится на первую половину ХХ в. В это время вышли в свет публикации А.А. Бобринского (1910), Г.К. Лукомского (1923), Д.Д. Иванова (1924), А.И. Батенина (1925), Н.Н. Соболева (1939), в которых обозначен такой феномен культурного наследия как древнерусская мебель. Памятники объединялись в раздел «Народная мебель», сочетая древние образцы и предметы крестьянского быта XIX в..

The beginning and development of the study of old Russian furniture falls on the first half of the twentieth century. At this time, the publications of A. A. Bobrinsky (1910), G. K. Lukomsky (1923), D. D. Ivanov (1924), A. I. Batenin (1925), and N. N. Sobolev (1939) were published. These researches identified the phenomenon of cultural heritage as old Russian furniture. These artefacts were United under the name "folk furniture", combining ancient samples of peasant household items of the XIX century.
THE ROLE OF SCIENTIFIC EXPEDITIONS AND «SEA STATIONS» IN SHAPING THE ART NOUVEAU STYLE IN RUSSIA AND EUROPE
Authors: Графова Елена Олеговна
Published: August 2024

Формирование стиля «модерн» тесным образом связано с развитием науки рубежа XIXXX вв. Результаты научно-исследовательских экспедиций данной эпохи оказали серьёзное влияние на становление художественных форм искусства модерна и, в значительной мере, содержат в себе ключ к пониманию искусства и культуры данного исторического периода в Европе и в России.

The formation of the "modern" style is closely related to the development of science at the turn of the XIX-XX centuries. The results of research expeditions of this era had a serious impact on the formation of art forms of art Nouveau and, to a large extent, contain the key to understanding the art and culture of this historical period in Europe and in Russia.
PROBLEMS OF ESTABLISHMENT AND EXISTENCE OF PROTECTIVE ZONES OF CULTURAL HERITAGE OBJECTS
Authors: Андреева Александра Юрьевна , Халиков Искандер Альфредович
Published: August 2024

В статье проведен анализ условий создания защитных зон вокруг объектов культурного наследия. По мнению авторов, подобные охранные меры должны были стать формой противодействия незаконному освоению территорий, неразрывно связанных с памятниками, принятыми на государственную охрану. Разрабатывая их, законодатель стремился создать механизм оперативной защиты ценных в историко-культурном плане земельных участков с находящимися на них архитектурными сооружениями, вводимый в действие сразу после включения объекта в государственный реестр. Однако практическое применение положений ст. 34.1 Федерального закона от 25 июня 2002 г. № 73-ФЗ «Об объектах культурного наследия (памятниках истории и культуры) народов Российской Федерации» вызвало затруднения. Так, создание защитных зон в городах с плотной исторической застройкой, связано с необходимостью проведения государственной историко-культурной экспертизы с целью установления территориальных границ. Как следствие, происходит затягивание сроков создания защитных зон памятников истории и культуры. Кроме этого, в статье обращено внимание на то, что сохранение объектов культурного наследия, выявленных объектов культурного наследия, находящихся в границах защитных зон памятников истории и культуры, осложнено общим запретом на хозяйственную и строительную деятельность. Авторами даны рекомендации по изменению условий организации и ведения реставрационных работ на территории защитных зон.

The article analyzes the conditions for creating protective zones around cultural heritage objects. According to the authors, such protective measures should have been a form of counteraction to the illegal development of territories that are inextricably linked with monuments accepted for state protection. When developing them, the legislator sought to create a mechanism for the operational protection of historically and culturally valuable land plots with architectural structures located on them, which is put into effect immediately after the object is included in the state register. However, the practical application of the provisions of art. 34.1 of Federal law № 73-FZ «On objects of cultural heritage (historical and cultural monuments) of the peoples of the Russian Federation» caused difficulties. Thus, the creation of protective zones in cities with dense historical buildings is associated with the need for state historical and cultural expertise in order to establish territorial boundaries. As a result, there is.
FORMATION AND DEVELOPMENT OF THE SYSTEM OF PAROCHIAL AND RURAL SCHOOLS ON THE TERRITORY OF THE KURSK PROVINCE IN THE XIX CENTURY
Authors: Капнин Владислав Олегович
Published: August 2024

Становление и развитие народного просвещения в Российской Империи началось в начале XVIII века, но в Курской губернии данная образовательная реформа была проведена только в середине XVIII века. Одним из главных элементов новой системы образования стали церковно-приходские и земские школы. В Курской губернии имелись свои специфические предпосылки к переходу на новую систему образования, а также индивидуальные черты нового устройства учебных заведений.

The formation and development of public education in the Russian Empire started at the beginning of the XVIII century, but in the Kursk province this educational reform was carried out only in the middle of the XVIII century. One of the main elements of the new education system was the parochial and rural schools. The Kursk province had its own specific prerequisites for the transition to a new system of education, as well as individual features of the new structure of educational institutions. This will be discussed in this article
Clinical Diagnostic Algorithm and Management Tactics for Suspected Ectopic Pregnancy
Authors: Смолей Н.А.
Published: August 2024

Приведен анализ различных клинических случаев эктопической беременности, включающих шеечную беременность, эктопическую беременность в культе маточной трубы после перенесенной тубэктомии, сочетание нарушенной трубной беременности слева и прогрессирующей трубной беременности справа. Рассмотрены основные этиологические факторы, приводящие к возникновению данной патологии, клинико-диагностический алгоритм и тактика ведения.

There is analysis of various clinical cases of ectopic pregnancy that include cervical pregnancy, ectopic pregnancy in the fallopian tube stump after tubectomy, the case of a combination of disturbed tubal pregnancy on the left and progressive tubal pregnancy on the right. The etiological factors of this pathology, clinical and diagnostic aspects and management tactics are discussed.
COMPLEXING OF AREAL MAGNETIC DATA AND PALEOMAGNETIC STUDIES IN CRIMEA TO CLARIFY A GEOLOGICAL STRUCTURE OF BODRAK FORMATION INTRUSIONS OF THE MIDDLE JURASSIC
Authors: Золотая Л.А. , Коснырева М.В. , Паленов А.Ю. , Филиппович А.В.
Published: August 2024

Магматические образования в Крыму изучаются геологами более ста лет. Эти исследования совершаются преимущественно методом натурных наблюдений, которые не могут дать ответ на многие важные вопросы о строении и генезисе этих образований. Магматические тела имеют высокие значения намагниченности, по сравнению с вмещающими породами, что является физическими предпосылками для применения магниторазведки. Статья посвящена анализу новых данных высокоточной площадной магнитной съемки масштаба 1:10000, выполненной на периферийной части Качинского антиклинория Крыма в районе реки Бодрак у села Трудолюбовка в комплексе с палеомагнитными исследованиями интрузий средней юры J2bd. Авторы по площадным магнитным данным показывают вариант площадного картирования сложнодислоцированного интрузивного комплекса и дополняют свои исследования построением магнитных моделей геологического разреза с учетом данных остаточной намагниченности, значения которой получены по данным отобранной палеомагнитной коллекции. Полученные результаты позволяют по-новому рассмотреть пространственно-временные соотношения интрузий бодракской свиты и вмещающих их горных пород на исследуемой территории.

Magmatic formations in Crimea have been studied by geologists for over a hundred years. These studies are carried out mainly by the method of field observations, which cannot answer many important questions about the structure and genesis of these formations. Magmatic bodies have high magnetization values in comparison with containing rocks, which is the physical prerequisite for use of magnetic prospecting. This article focuses on the analysis of new high-precision areal magnetic survey data at a scale of 1:10000, performed on peripheral part of the Kachinsky anticlinorium in Crimea, near to the Bodrak river and Trudolubovka village, in a complex with paleomagnetic studies of the Middle Jurassic J2bd intrusions. The authors, using magnetic data, show a variant of areal mapping of a complexly deployed intrusive complex and supplement their studies with magnetic modeling of a geological section. Magnetic modeling was carried out taking into account a remanent magnetization data, which values were obtained from data of selected paleomagnetic collection. The results allow us to re-examine the spatiotemporal relationships between intrusions of the Bodrak formation and rocks enclosing them in the study area.
THE DETECTION OF FROZEN AND GAS-SATURATED SOILS IN THE GULF OF OB OF THE KARA SEA ACCORDING TO THE DATA OF THE UNDERWATER ELECTRICAL RESISTIVITY TOMOGRAPHY WITH ACOUSTIC PROFILING AND DRILLING
Authors: Миринец А.К. , Бобачев А.А. , Миронюк С.Г.
Published: August 2024

В статье приведены результаты работ методом электротомографии в донной модификации, которые проводились с целью изучения электрических свойств грунтов в верхней части разреза и построения геологических разрезов с привлечением данных бурения инженерно-геологических скважин. В ходе работы получена новая информация о физических свойствах донных отложений. Результаты показали эффективность использования электротомографии в Обской губе Карского моря, так как удалось проследить кровлю многолетнемерзлых пород и проанализировать, как изменяются физические свойства грунта по разрезу до 50 м от донной поверхности, несмотря на наличие газонасыщенных отложений в верхней части разреза. Помимо этого, проведен совместный анализ атрибутов среднеквадратичных амплитуд для методов акустического профилирования и электротомографии для выявления закономерностей в областях распространения газонасыщенных отложений.

We present the results of underwater electrical resistivity tomography surveys that were carried out in order to research the electrical properties of soils in the upper part of the section and create geological sections using drilling data from engineering geological boreholes. During investigations, new information was obtained about physical characteristics of bottom sediments. The results are showed the effectiveness of electrical resistivity tomography in the Gulf of Ob of the Kara Sea, as it was possible to trace the surface of permafrost and analyze how the physical characteristics of the soil change along the section up to 50 m from the seafloor, despite the gas-saturated sediments in the upper part of the section. Moreover, a joint analysis of the RMS amplitude attributes for acoustic profiling and electrical resistivity tomography was carried out to identify trends in the gas-saturated areas.
FEATURES OF INTERPRETIVE RE-PROCESSING OF SEISMIC DATA MOGT-3D IN THE CONDITIONS OF EASTERN SIBERIA
Authors: Чистякова П.И. , Арутюнянц И.В. , Клешнин А.Б. , Пронина М.Н.
Published: August 2024

Работа посвящена особенностям интерпретационной переобработки сейсмических данных МОГТ-3D в условиях Восточной Сибири в пределах Непско-Ботуобинской антеклизы. Исследуемый район обладает хорошим ресурсным потенциалом, при этом в связи со сложным геологическим строением качество получаемого сейсмического материала не всегда пригодно для проведения динамической интерпретации. Представляемый авторами подход к переобработке архивных сейсмических данных приводит к улучшению качества сейсмического изображения, повышению надежности интерпретации и точности прогноза. Использование предлагаемой методики приобретает все большую актуальность в связи с необходимостью получения геологически более достоверных результатов, не привлекая дополнительного финансирование на проведение новых полевых сейсмических работ.

The work is devoted to the peculiarities of interpretative re-processing of seismic data of MOGT-3D in the conditions of Eastern Siberia within the Nepsko-Botuobinskaya anteclise. The area under study has a good resource potential, while, due to the complex geological structure, the quality of the resulting seismic material is not always suitable for dynamic interpretation. The approach presented by the authors to the re-processing of archival seismic data leads to an improvement in the quality of the seismic image, an increase in the reliability of interpretation and accuracy of the forecast. The use of the proposed methodology is becoming increasingly relevant due to the need to obtain geologically more reliable results without attracting additional funding for new field seismic work.
WELLBORE STABILITY ANALYSIS IN THE MAIKOP SERIES OF CISCAUCASIA
Authors: Роженков Е.А. , Гальперина А.А. , Кулапова М.В.
Published: August 2024

На примере отложений майкопской серии Центрального и Восточного Предкавказья проведено геомеханическое моделирование на основе данных ГИС и определены безопасные границы плотности бурового раствора. Показано, что первоначально использованных при бурении значений недостаточно для обеспечения стабильности. Повышение плотности бурового раствора на 0,2 г/см3 приведет к уменьшению разрушения стенок скважины и снижению рисков возникновения осложнений.

A geomechanical model based on well log data was constructed by the example of the deposits of the Maikop series of the Middle and Eastern Ciscaucasia. Based on the determined safe mud weight window it is shown that the original values are not sufficient to ensure wellbore stability. Mud density increase by 0,2 g/cc will reduce wellbore failure and mitigate the risks of stability problems.