bluuebunny/crossref_metadata_2025 huggingface dataset:
The classic prognostic factors in advanced Hodgkin’s lymphoma patients are losing their meaning at the time of Pet-guided treatments
Authors:   Fondazione Italiana Linfomi (Onlus), Bari Alessia , Marcheselli Raffaella , Sacchi Stefano , Re Alessandro , Pagani Chiara , Tucci Alessandra , Botto Barbara , Vitolo Umberto , Molinari Anna Lia , Puccini Benedetta , Pulsoni Alessandro , Santoro Armando , Tani Monica , Nassi Luca , Meli Erika , Pavone Vincenzo , Bonfichi Maurizio , Evangelista Andrea , Gioia Daniela , Levis Alessandro , Zinzani Pierluigi
Published: December 2019

The International Prognostic Score (IPS) is the most commonly used risk stratification tool for patients with advanced Hodgkin lymphoma (HL). It incorporates seven clinical parameters independently associated with a poorer outcome: male sex, age, stage IV, hemoglobin level, white blood cell and lymphocyte counts, and albumin level. Since the development of the IPS, there have been significant advances in therapy and supportive care. Recent studies suggest that the IPS is less discriminating due to improved outcomes with ABVD therapy. The aim of the present study was to asses if classic prognostic factors maintain their prognostic meaning at the time of response-adapted treatment based on interim PET scans. We evaluated the prognostic significance of IPS in the 520 advanced stage HL patients enrolled in the PET-guided, HD0801 trial in which PET2-positive patients underwent a more intense treatment with an early stem-cell transplantation after 2 cycles of ABVD. We observed that in these patients, the IPS completely loses its prognostic value together with all the single parameters that contribute to the IPS. Furthermore, neutrophils, monocytes, lymphocytes, and the ratio among them also no longer had any predictive value. We believe that the substantial improvement in survival outcomes in PET2-positive patients treated with early autologous transplantation could explain the complete disappearance of the residual prognostic significance of the IPS.
Colonization pressure: a second null model for invasion biology
Authors: Blackburn Tim M. , Cassey Phillip , Duncan Richard P.
Published: December 2019

Understanding the causes of spatial variation in the distribution and richness of alien species is a key goal of invasion biology. Thanks to the increasing availability of geographical compendia of alien species it is also the subject of a burgeoning scientific literature. Here, we review elements of this literature to argue that understanding the causes of variation in alien species richness cannot be achieved without knowledge of the number of species introduced to an area—termed colonization pressure. The implications of a lack of information on colonization pressure are widespread and, we believe, poorly recognised. We start by discussing a recent general model for alien species richness that demonstrates why colonization pressure is a fundamental determinant of this. We then explore the literature on alien species richness, particularly on islands, to demonstrate how failing to account for colonization pressure affects our perception of richness drivers. We further show that ignoring colonization pressure can bias our understanding of patterns in the distributions of alien species. We finish by discussing situations when colonization pressure may be more or less important for our understanding of alien invasions.
Dissent in Consensusland: An Agonistic Problematization of Multi-stakeholder Governance
Authors: Fougère Martin , Solitander Nikodemus
Published: December 2019

Multi-stakeholder initiatives involve actors from several spheres of society (market, civil society and state) in collaborative arrangements to reach objectives typically related to sustainable development. In political CSR literature, these arrangements have been framed as improvements to transnational governance and as being somehow democratic. We draw on Mouffe’s works on agonistic pluralism to problematize the notion that consensus-led multi-stakeholder initiatives bring more democratic control on corporate power. We examine two initiatives which address two very different issue areas: the Roundtable on Sustainable Palm Oil (RSPO) and the Bangladesh Accord on Fire and Building Safety (The Accord). We map the different kinds of adversarial relations involved in connection with the issues meant to be governed by the two initiatives, and find those adversarial relations to take six main shapes, affecting the initiatives in different ways: (1) competing regulatory initiatives; (2) pressure-response relations within multi-stakeholder initiatives; (3) pressure-response relations between NGOs and states through multi-stakeholder initiatives; (4) collaboration and competition between multi-stakeholder initiatives and states; (5) pressure-response relations between civil society actors and multi-stakeholder initiatives; and (6) counter-hegemonic movements against multi-stakeholder initiatives as hegemonic projects. We conclude that multi-stakeholder initiatives cannot be democratic by themselves, and we argue that business and society researchers should not look at democracy or politics only internally to these initiatives, but rather study how issue areas are regulated through interactions between a variety of actors—both within and without the multi-stakeholder initiatives—who get to have a legitimate voice in this regulation.
A Tale of Two Markets: How Lower-end Borrowers Are Punished for Bank Regulatory Failures in Nigeria
Authors: Omede P. I.
Published: December 2019

In 2009, the Nigerian banking system witnessed a financial crisis caused by elite borrowers in the financial market. Regulatory response to the Nigerian crisis closely mirrored the international response with increased capital and liquidity thresholds for commercial banks. While the rise of consumer protection on the agenda of prudential supervisors internationally was logical in that consumer debt was the main cause of the global recession, the Nigerian banking reforms of 2009 disproportionately affected access by poorer consumers, who ironically had little to do with the underlying causes of the crisis. As lending criteria become more stringent, poorer consumers of credit products are pushed into informal markets because of liquidity-induced credit rationing. Overall, consumer protection is compromised because stronger consumer protection rules for the formal sector benefits borrowers from formal institutions who constitute the minority of borrowers in all markets. While the passage of regulation establishing credit bureaux and the National Collateral Registry will, in theory, ease access to credit especially by lower-end borrowers, the vast size of the informal market continues to compound the information asymmetry problem, fiscal policies to tackle structural economic issues such as unemployment and illiteracy remain to be initiated, and bank regulators continue to pander to elite customers with policy responses that endorse too big to fail but deems lower-end consumers too irrelevant to save. The essay concluded that addressing the wide disparity in access to credit between the rich and poor through property rights reforms to capture the capital of the informal class, promoting regulation to check loan concentration, and stimulating competition by allowing Telecommunication Companies (TELCOs) and fintech companies to carry on lending activities because of their superior knowledge of lower-end markets will facilitate greater access. The risk of systemic failure deriving from consumer credit in Nigeria is insignificant compared to the consumer vulnerabilities resulting from the exposure of consumers to unregulated products in the informal market.
Rationale and design of “Can Very Low Dose Rivaroxaban (VLDR) in addition to dual antiplatelet therapy improve thrombotic status in acute coronary syndrome (VaLiDate-R)” study
Authors: Gue Ying X. , Kanji Rahim , Wellsted David M. , Srinivasan Manivannan , Wyatt Solange , Gorog Diana A.
Published: December 2019

Impaired endogenous fibrinolysis is novel biomarker that can identify patients with ACS at increased cardiovascular risk. The addition of Very Low Dose Rivaroxaban (VLDR) to dual antiplatelet therapy has been shown to reduce cardiovascular events but at a cost of increased bleeding and is therefore not suitable for all-comers. Targeted additional pharmacotherapy with VLDR to improve endogenous fibrinolysis may improve outcomes in high-risk patients, whilst avoiding unnecessary bleeding in low-risk individuals. The VaLiDate-R study (ClinicalTrials.gov Identifier: NCT03775746, EudraCT: 2018-003299-11) is an investigator-initiated, randomised, open-label, single centre trial comparing the effect of 3 antithrombotic regimens on endogenous fibrinolysis in 150 patients with ACS. Subjects whose screening blood test shows impaired fibrinolytic status (lysis time > 2000s), will be randomised to one of 3 treatment arms in a 1:1:1 ratio: clopidogrel 75 mg daily (Group 1); clopidogrel 75 mg daily plus rivaroxaban 2.5 mg twice daily (Group 2); ticagrelor 90 mg twice daily (Group 3), in addition to aspirin 75 mg daily. Rivaroxaban will be given for 30 days. Fibrinolytic status will be assessed during admission and at 2, 4 and 8 weeks. The primary outcome measure is the change in fibrinolysis time from admission to 4 weeks follow-up, using the Global Thrombosis Test. If VLDR can improve endogenous fibrinolysis in ACS, future large-scale studies would be required to assess whether targeted use of VLDR in patients with ACS and impaired fibrinolysis can translate into improved clinical outcomes, with reduction in major adverse cardiovascular events in this high-risk cohort.
Lessons for blue degrowth from Namibia’s emerging blue economy
Authors: Carver Rosanna
Published: December 2019

Globally there has been recognition that there is little consensus attributed to the definition of the blue economy. However, despite this acknowledgement, the blue economy is championed for its development potential by the African Union and subsequently, several African states. Having formalised the agenda in its fifth National Development Plan Namibia is working to implement a governance and management framework to “sustainably maximise benefits from marine resources” by 2020 (Republic of Namibia in Namibia’s 5th National Development Plan (NDP5) 2017). Concurrently, new entrants, such as marine mineral mining projects, have emerged in recognition of the potential offered within the state’s Exclusive Economic Zone. This article argues that the uptake of the blue economy is shaped by multiple, and often conflicting, interests. The emergence of the agenda is not apolitical, nor has it been established in isolation from exogenous actors and interests. Subsequently, this article suggests that the critique of the emerging blue economy should be applied to discussions of a blue degrowth movement, to avoid transposing a new agenda over another. As demonstrated with reference to Namibia, contextual and historical issues need to be recognised by degrowth discussions, and their inherent and continued structural effects analysed. This is of particular importance when considering whose voices are represented or excluded by such agendas, complicated by the (geo)physical characteristics of the marine sphere.
Reservoir heterogeneity and fracture parameter determination using electrical image logs and petrophysical data (a case study, carbonate Asmari Formation, Zagros Basin, SW Iran)
Authors: Aghli Ghasem , Moussavi-Harami Reza , Mohammadian Ruhangiz
Published: December 2019

Assessment of reservoir and fracture parameters is necessary to optimize oil production, especially in heterogeneous reservoirs. Core and image logs are regarded as two of the best methods for this aim. However, due to core limitations, using image log is considered as the best method. This study aims to use electrical image logs in the carbonate Asmari Formation reservoir in Zagros Basin, SW Iran, in order to evaluate natural fractures, porosity system, permeability profile and heterogeneity index and accordingly compare the results with core and well data. The results indicated that the electrical image logs are reliable for evaluating fracture and reservoir parameters, when there is no core available for a well. Based on the results from formation micro-imager (FMI) and electrical micro-imager (EMI), Asmari was recognized as a completely fractured reservoir in studied field and the reservoir parameters are mainly controlled by fractures. Furthermore, core and image logs indicated that the secondary porosity varies from 0% to 10%. The permeability indicator indicates that zones 3 and 5 have higher permeability index. Image log permeability index shows a very reasonable permeability profile after scaling against core and modular dynamics tester mobility, mud loss and production index which vary between 1 and 1000 md. In addition, no relationship was observed between core porosity and permeability, while the permeability relied heavily on fracture aperture. Therefore, fracture aperture was considered as the most important parameter for the determination of permeability. Sudden changes were also observed at zones 1-1 and 5 in the permeability trend, due to the high fracture aperture. It can be concluded that the electrical image logs (FMI and EMI) are usable for evaluating both reservoir and fracture parameters in wells with no core data in the Zagros Basin, SW Iran.
Salinity Effects on Survival and Reproduction of Hydrozoan Eleutheria dichotoma
Authors: Dańko Aleksandra , Schaible Ralf , Dańko Maciej J.
Published: December 2019

Salinity conditions experienced by organisms in coastal regions may shape their life histories. Here, salinity’s impact on reproduction and survival of the hydrozoanEleutheria dichotomawas investigated using laboratory-cultured individuals originating from Banyuls-sur-Mer (southern France) collected several decades ago. During the experiment (October 2014–July 2015), hydroid colonies and medusae were exposed to three salinities (25, 35, 45). Asexually budded medusae were collected from colonies and reared for three generations obtained by asexual budding of medusae. Salinities experienced by hydroid colonies had only minor effects on initial size, time to maturity, medusa budding, sexual production of planulae by medusae, and survival. In contrast, salinities experienced by medusae influenced their life histories. Compared with medium salinity (35), low-salinity medusae (25) had an earlier onset and higher rates of asexual budding, a later onset and slower rates of sexual reproduction, and higher mortality, which could result from allocation tradeoffs. The increased production of planulae by medusae in low salinity indicated that they were transitioning to a benthic polyp life form more resistant to environmental stress. High salinity (45) delayed asexual maturity, prevented sexual maturity in medusae, and led to lower survival and asexual reproduction rates. Budding rates decreased across the generations; however, planula production rates decreased in medium salinity but increased in low salinity. This might be explained by the accumulation of damage with each generation, and/or by internal rhythms. The flexible responses of this tractable model organism,Eleutheria dichotoma, to salinity change may be useful in future studies on changing estuarine conditions.
Relationships Between Perspective-Taking, Empathic Concern, and Self-rating of Empathy as a Physician Among Medical Students
Authors: Yu Jihye , Lee Sukyung , Kim Miran , Lim Kiyoung , Chang Kihong , Lee Mijin
Published: December 2019

Objective

The aim of this study was to ascertain the relationships between perspective-taking, empathic concern, and self-rating of empathy as a physician among medical students.

Methods

This study analyzed the questionnaire responses of 152 medical students enrolled in Ajou University School of Medicine, Suwon, Republic of Korea, in 2018. As measurement instruments, the authors applied the Interpersonal Reactivity Index (IRI) and Korean Student Version of the Jefferson Scale of Physician Empathy (Korean JSPE-S), and then examined participant characteristic variables based on the obtained data and conducted subsequent correlation analyses of subscales, one-way ANOVA, and regression analyses.

Results

Medical students with clinical clerkship experience demonstrated higher levels of perspective-taking and empathy as physicians than did students without experience. Moreover, perspective-taking and empathic concern were significant predictors of medical students’ empathy as physicians in the regression model.

Conclusions

Medical students with higher scores in perspective-taking and empathic concern demonstrated higher levels of perception regarding the necessity and importance of empathy as a physician in patient-physician relationships. Therefore, in actual medical situations with patient-centered therapy, to enhance the levels of physician empathy, medical education should focus on the understanding of other persons’ opinions and interpersonal interactions accompanied by empathic concern.
A review of stochastic block models and extensions for graph clustering
Authors: Lee Clement , Wilkinson Darren J.
Published: December 2019

There have been rapid developments in model-based clustering of graphs, also known as block modelling, over the last ten years or so. We review different approaches and extensions proposed for different aspects in this area, such as the type of the graph, the clustering approach, the inference approach, and whether the number of groups is selected or estimated. We also review models that combine block modelling with topic modelling and/or longitudinal modelling, regarding how these models deal with multiple types of data. How different approaches cope with various issues will be summarised and compared, to facilitate the demand of practitioners for a concise overview of the current status of these areas of literature.
The Hydrogen Bond, the Halogen Bond and Rotational Spectroscopy: A Personal Retrospective
Authors: Legon Anthony
Published: December 2019

This article is a personal, chronological account of experimental work carried out on the hydrogen bond, the halogen bond and other non-covalent interactions by my research group using (mainly) rotational spectroscopy since 1974. It is not intended to be comprehensive, and therefore does not include contributions made by many groups in the last 40 years or so.
On the primeness of near-rings
Authors: Al-Shaalan Khalid H.
Published: December 2019

In this paper, we study the different kinds of the primeness on the class of near-rings and we give new characterizations for them. For that purpose, we introduce new concepts called set-divisors, ideal-divisors, etc. and we give equivalent statements for 3-primeness which make 3-primeness looks like the forms of the other kinds of primeness. Also, we introduce a new different kind of primeness in near-rings called K-primeness which lies between 3-primeness and e-primeness. After that, we study different kinds of prime ideals in near-rings and find a connection between them and new concepts called set-attractors, ideal-attractors, etc. to make new characterizations for them. Also, we introduce a new different kind of prime ideals in near-rings called K-prime ideals.
On Seasons of an Indigenous Feminism, Kinship, and the Program of Home Management
Authors: Anderson Kim
Published: December 2019

It's early evening, a Friday night in October, and I have hauled myself off the couch to make dinner for my son and me. It's just us; the more active cooks in our family are away and the house is quiet. I've spent all afternoon immersed in scholarly literature about the history of home economics, and I chuckle at the irony as I pour premade marinara sauce over the noodles. I call up my son from the basement, where he's been immersed in his own studies, and find myself musing about our beginnings together—that spring when he arrived twenty-three years ago just as the trees were beginning to bud. I mutter about how perplexing cooking and mothering have been for me, and realize that these glimpses of me as a young mother and ponderings of how to take up increasing responsibilities as a middle-aged Indigenous “academic auntie” bookend my seasons of Indigenous feminist growth.
Stacked Regression and Poststratification
Authors: Ornstein Joseph T.
Published: December 2019

I develop a procedure for estimating local-area public opinion called stacked regression and poststratification (SRP), a generalization of classical multilevel regression and poststratification (MRP). This procedure employs a diverse ensemble of predictive models—including multilevel regression, LASSO, k-nearest neighbors, random forest, and gradient boosting—to improve the cross-validated fit of the first-stage predictions. In a Monte Carlo simulation, SRP significantly outperforms MRP when there are deep interactions in the data generating process, without requiring the researcher to specify a complex parametric model in advance. In an empirical application, I show that SRP produces superior local public opinion estimates on a broad range of issue areas, particularly when trained on large datasets.
Emergence of Hilltop Settlements in the Southeastern Baltic: New AMS14C Dates from Lithuania and Revised Chronology
Authors: Podėnas Vytenis
Published: December 2019

The emergence of hilltop settlements presents a pattern of the first enclosed sites that reflect economic development in several regions within the Southeastern Baltic Bronze Age. This novelty reflects increasing social complexity, differentiating economic relations, as well as rising tension in the region. The phenomenon has received a great deal of interpretation, but chronological problems still remain understudied. Researchers tend to seek the start of hilltop settling practice from early to late II millennium BC. This paper presents14C dates from 7 sites in inland Lithuania, where hitherto no absolute dates were published. The majority of absolute dates has been calibrated to the Hallstatt radiocarbon calibration plateau (ca. 800–400 cal BC) which is significantly later than previously presumed based on dates from Belarusian sites. However, several dates from previously dated hilltop settlements in the region predate the effect. These results indicate the start of hilltop settling practice around 11th–9th centuries cal BC. Review of new and previously published radiocarbon dates suggests a different internal development between SE Baltic coastal and inland regions, likely locating zones, where economic outside stimulus preconditioning emergence of hilltop settlements occurred earlier.
Open Access and Academic Journals in Canada: A Political Science Perspective
Authors: Papillon Martin , O'Neill Brenda , Bourque Mélanie , Marland Alex , White Graham
Published: December 2019

The push to implement Open Access (OA) as the new standard for academic research dissemination is creating very real pressures on academic journals. In Canada, the Social Science and Humanities Research Council (SSHRC) recently adopted a policy requiring that journals applying for its Aid to Scholarly Journals (ASJ) grant make their scholarly content freely accessible after no more than a 12-month delay. For journals such as the Canadian Journal of Political Science (CJPS) that not only publish high-quality, peer-reviewed articles to a specialized audience but also support the work of scholarly associations through the revenues they generate, the push to move to OA comes with a number of challenges. The Canadian Political Science Association (CPSA) and the Société québécoise de science politique (SQSP) established a committee to chart the best course of action for the CJPS in light of this changing landscape. This article summarizes the key findings of the committee and underscores some of the challenges of OA for journals with a profile similar to the CJPS, as well as for the broader research ecosystem that they support.
An artificial intelligence algorithm that differentiates anterior ethmoidal artery location on sinus computed tomography scans
Authors: Huang J , Habib A-R , Mendis D , Chong J , Smith M , Duvnjak M , Chiu C , Singh N , Wong E
Published: December 2019

Objective

Deep learning using convolutional neural networks represents a form of artificial intelligence where computers recognise patterns and make predictions based upon provided datasets. This study aimed to determine if a convolutional neural network could be trained to differentiate the location of the anterior ethmoidal artery as either adhered to the skull base or within a bone ‘mesentery’ on sinus computed tomography scans.

Methods

Coronal sinus computed tomography scans were reviewed by two otolaryngology residents for anterior ethmoidal artery location and used as data for the Google Inception-V3 convolutional neural network base. The classification layer of Inception-V3 was retrained in Python (programming language software) using a transfer learning method to interpret the computed tomography images.

Results

A total of 675 images from 388 patients were used to train the convolutional neural network. A further 197 unique images were used to test the algorithm; this yielded a total accuracy of 82.7 per cent (95 per cent confidence interval = 77.7–87.8), kappa statistic of 0.62 and area under the curve of 0.86.

Conclusion

Convolutional neural networks demonstrate promise in identifying clinically important structures in functional endoscopic sinus surgery, such as anterior ethmoidal artery location on pre-operative sinus computed tomography.
Three-dimensional printing as a tool in otolaryngology training: a systematic review
Authors: Chen G , Jiang M , Coles-Black J , Mansour K , Chuen J , Amott D
Published: December 2019

Objective

Three-dimensional printing is a revolutionary technology that is disrupting the status quo in surgery. It has been rapidly adopted by otolaryngology as a tool in surgical simulation for high-risk, low-frequency procedures. This systematic review comprehensively evaluates the contemporary usage of three-dimensional printed otolaryngology simulators.

Method

A systematic review of the literature was performed with narrative synthesis.

Results

Twenty-two articles were identified for inclusion, describing models that span a range of surgical tasks (temporal bone dissection, airway procedures, functional endoscopic sinus surgery and endoscopic ear surgery). Thirty-six per cent of articles assessed construct validity (objective measures); the other 64 per cent only assessed face and content validity (subjective measures). Most studies demonstrated positive feedback and high confidence in the models’ value as additions to the curriculum.

Conclusion

Whilst further studies supported with objective metrics are merited, the role of three-dimensional printed otolaryngology simulators is poised to expand in surgical training given the enthusiastic reception from trainees and experts alike.
An introductory guide to fluid models with anisotropic temperatures. Part 2. Kinetic theory, Padé approximants and Landau fluid closures
Authors: Hunana P. , Tenerani A. , Zank G. P. , Goldstein M. L. , Webb G. M. , Khomenko E. , Collados M. , Cally P. S. , Adhikari L. , Velli M.
Published: December 2019

In Part 2 of our guide to collisionless fluid models, we concentrate on Landau fluid closures. These closures were pioneered by Hammett and Perkins and allow for the rigorous incorporation of collisionless Landau damping into a fluid framework. It is Landau damping that sharply separates traditional fluid models and collisionless kinetic theory, and is the main reason why the usual fluid models do not converge to the kinetic description, even in the long-wavelength low-frequency limit. We start with a brief introduction to kinetic theory, where we discuss in detail the plasma dispersion function

$Z(\unicode[STIX]{x1D701})$

, and the associated plasma response function

$R(\unicode[STIX]{x1D701})=1+\unicode[STIX]{x1D701}Z(\unicode[STIX]{x1D701})=-Z^{\prime }(\unicode[STIX]{x1D701})/2$

. We then consider a one-dimensional (1-D) (electrostatic) geometry and make a significant effort to map all possible Landau fluid closures that can be constructed at the fourth-order moment level. These closures for parallel moments have general validity from the largest astrophysical scales down to the Debye length, and we verify their validity by considering examples of the (proton and electron) Landau damping of the ion-acoustic mode, and the electron Landau damping of the Langmuir mode. We proceed by considering 1-D closures at higher-order moments than the fourth order, and as was concluded in Part 1, this is not possible without Landau fluid closures. We show that it is possible to reproduce linear Landau damping in the fluid framework to any desired precision, thus showing the convergence of the fluid and collisionless kinetic descriptions. We then consider a 3-D (electromagnetic) geometry in the gyrotropic (long-wavelength low-frequency) limit and map all closures that are available at the fourth-order moment level. In appendix A, we provide comprehensive tables with Padé approximants of

$R(\unicode[STIX]{x1D701})$

up to the eighth-pole order, with many given in an analytic form.
Re-establishment of the Mediterranean monk seal Monachus monachus in Cyprus: priorities for conservation
Authors: Nicolaou Haris , Dendrinos Panagiotis , Marcou Melina , Michaelides Savvas , Karamanlidis Alexandros A.
Published: December 2019

Once widespread throughout the Black and Mediterranean Seas and the coasts of north Africa, the Endangered Mediterranean monk seal Monachus monachus has disappeared throughout most of its original range. In Cyprus evidence suggests that the species became effectively extinct at the end of the 20th century. Following an increase of seal sightings around the island, a monitoring programme was established in 2009 to evaluate the status of the species. During 2009–2018, using field surveys, photographs from camera traps and an information network, we recorded an increasing number of seal sightings, and the birth of several pups, indicating the permanent presence of the species on the island. This is the first recorded re-establishment of a Mediterranean monk seal population in an area of its former range following near eradication.
The Qualifying Field Exam: What Is It Good For?
Authors: McMahon Nicole , Alcantara Christopher , Stephenson Laura B.
Published: December 2019

Most political scientists self-identify as a comparativist, theorist, Americanist, or another label corresponding with the qualifying field exams (QFE) that they passed during their doctoral studies. Passing the QFE indicates that a graduate student or faculty member is broadly familiar with the full range of theories, approaches, and debates within a subfield or research theme. The value of the QFE as a form of certification, however, depends on the extent to which the subfield or theme is cohesive in and of itself as well as whether departmental lists draw on a common pool of publications. This article investigates the value of the QFE by examining the cohesiveness of 16 Canadian politics PhD QFE lists. Our findings suggest that it is problematic to assume that scholars who pass a QFE share a common knowledge base.
Let’s Talk about Sex: Examining the Factors Influencing Congressional Response to #MeToo on Twitter
Authors: Clark Jennifer Hayes , Evans Heather K.
Published: December 2019

This article examines the factors that influence whether members of Congress tweet about the #MeToo movement. Whereas social-identity theory suggests that congresswomen would be more likely to tweet about #MeToo, congressional research argues that increased polarization has resulted in congresswomen bucking gender stereotypes and embracing more partisan behavior than might otherwise be expected (Pearson and Dancey 2011). We examine how gender, partisanship, and ideology shape the Twitter activity of members of Congress surrounding the #MeToo movement using an original dataset of their tweets since October 2017 when the #MeToo movement gained prominence on Twitter. Our findings show that gender and ideology are the strongest predictors of whether Congress members tweet about the #MeToo movement. Liberals—particularly liberal women—are leading the charge in bringing prominence to the #MeToo movement on Twitter.
Government-Corroborated Conspiracies: Motivating Response to (and Belief in) a Coordinated Crime
Authors: Calfano Brian Robert
Published: December 2019

Accusations of conspiracy are nothing new in American politics, but examples in which the government—usually cast as a key player in conspiracy theories—goes on record to corroborate that a conspiracy occurred are rare. I leveraged an experiment that randomly exposes both college-student and general-public subject pools to information about the 1979 House Select Committee on Assassination report of a probable conspiracy in the assassination of President John F. Kennedy. I find that those exposed to government corroboration of a conspiracy (1) are more prone to anger in response to the government report; (2) engage in an increased search of available media information about the assassination; and (3) are more likely to agree with the conclusion of a conspiracy in Kennedy’s murder. Implications for additional research about government pronouncements on controversial issues and follow-on public reaction also are discussed.
Between ‘Everyday’ and ‘Extraordinary’: Partition, violence and the communal riots of 1946 in Bihar
Authors: DUBEY ISHA
Published: December 2019

The year 1937 saw the establishment of Congress Ministries in eight of the eleven provinces in which the provincial elections had been held, Bihar being one of them. The resounding victory of the Congress which secured a clear majority in the province of Bihar and the dismal performance of the Muslim League seemed at the time to depict the mood of the people in general. It was taken as a clear rejection of the politics of communalism and separatism and as an expression of faith in the secular credentials of the Indian National Congress. However, less than a decade later, the province was gripped by severe communal tensions and had become one of the most prominent parts of India from where the movement for Pakistan drew support. This article thus explores the nature of the communal violence that occurred in Bihar in 1946 against the backdrop of the ‘escalating’ communal tensions during the late 1930s and early 1940s. It seeks to problematise the dichotomy that exists in literature on communal violence between moments of what have been called ‘extraordinary’ violence (such as riots) and the everyday structures of (what Gyanendra Pandey has called) ‘routine violence’. Through its analysis of contemporary material produced by the Muslim League, the Congress Ministry and the provincial British administration to explain the causes of the 1946 riots in Bihar, it argues that it is in the moments of rupture presented by riots that everyday structures of violence are trivialised or normalised through processes of ‘dichotomisation’, ‘dehumanisation’ and ‘denial’.
Metachronous NSCLC in previously irradiated patients: is re-irradiation with SBRT a good option as definitive treatment?
Authors: Spatola Corrado , Milazzotto Roberto Massimo , Tocco Alessandra , Raffaele Luigi , La Monaca Viviana , Salamone Vincenzo , Milone Pietro , Foti Pietro Valerio , Pergolizzi Stefano , Basile Antonio , Privitera Giuseppe
Published: December 2019

Aim:

Treatment of metachronous second primary non-small cell lung cancer (NSCLC) in patients already treated with definitive radiotherapy is a matter of debate, since most patients are excluded from surgical treatment, which remains a therapeutic standard for patients with isolated lung masses. Salvage chemotherapy or immunotherapy alone offers a low probability of disease control. The option of re-irradiation often remains the only viable, but the risks of severe acute or late toxicities affecting the surrounding normal tissues make this a real clinical challenge.

Materials and methods:

From January 2015 to April 2018, five patients (male/female: 4/1; age 54–81 years, median 68) with previously irradiated NSCLC presented with a second primary lung tumour.

Results:

A partial response was seen in four patients, one complete responses in the fifth. The toxicity was low: two patients experienced a grade 2 asymptomatic radiation pneumonitis after 6 and 12 months from the end of stereotactic body radiation therapy, resolved with cortisone therapy. No acute or late oesophageal or cardiac toxicity was found.

Findings:

In this work, we present our initial experience about the use of stereotactic radiotherapy technique in already irradiated patients. We reported a local disease control in all cases with an acceptable toxicity.
Radiotherapy treatment planning for prostate and nodes using variable planning ring
Authors: Yadav Poonam , Yan Yue , Paliwal Bhudatt R.
Published: December 2019

Background:

Prostate cancer is one of the most common solid malignancies and has a high morbidity rate. The uncertainty of the prostate location compromises the overall treatment plan optimisation. To account for the location uncertainty, the radiation oncologist needs to expand the margin of the planning target volume (PTV), which may increase the radiation toxicity to organs in proximity.

Materials and methods:

In this study, we investigated the quality of treatment plans for a patient with different ring sizes (2 and 3 cm). A small ring-shaped structure circumferentially around the PTV helps in defining the location of PTV. Prostate and pelvic node plans were analysed with dose prescription to 99% of PTV.

Results:

Additional ring-shaped structures led to more conformal dose coverage for target with reduced radiation side effects to nearby organ at risk (OAR). Expected treatment time was slightly higher for 2 cm ring compared to 3 cm ring. In case of prostate, expected duration was 4% higher, while for node plan, expected duration for 2 cm ring was 16% higher compared to 3 cm ring plan.

Conclusions:

It was observed that using a smaller size ring can lead to improved dose sparing to OAR with same target coverage as with larger dimension ring. The composite plans do not show any clinically significant difference in dose to OARs.
IN BATTLE FOR PEACE DURING ‘SCOUNDREL TIME’
Authors: Burden-Stelly Charisse
Published: December 2019

Using the praxis and persecution of William Edward Burghardt Du Bois as a case study, this article analyzes the ways in which anticommunism became a tool of investigating, policing, discrediting, and ultimately curtailing what I call “Radical Black Peace Activism.” During the Cold War, the U.S. state apparatus treated this form of activism as an anti-American, foreign-inspired threat to national security attributable to the Communist “peace offensive.” Radical Black Peace Activists linked the end of global conflict, disarmament, and non-proliferation with antiracism, anticolonialism, anti-imperialism, and socialism. They argued that progress and justice could only be realized through international cooperation and peaceful coexistence. In other words, they demanded a new world order that would displace the United States, and its relentless militarism, as the world’s police. The investigation, indictment, and defamation of W. E. B. Du Bois, which coincided with the intensification of the Korean War, is illustrative of how Radical Black Peace Activism was treated as a form of Soviet-backed subversion. Through anticommunism, the U.S. state apparatus deemed the use of anti-Black and antiradical repression imperative to its security, stability, and status as the global defender of freedom and democracy.
The Do’s and Don’ts of Psychophysical Methods for Interpretability of Psychometric Functions and Their Descriptors
Authors: García-Pérez Miguel Ángel , Alcalá-Quintana Rocío
Published: December 2019

Many areas of research require measuring psychometric functions or their descriptors (thresholds, slopes, etc.). Data for this purpose are collected with psychophysical methods of various types and justification for the interpretation of results arises from a model of performance grounded in signal detection theory. Decades of research have shown that psychophysical data display features that are incompatible with such framework, questioning the validity of interpretations obtained under it and revealing that psychophysical performance is more complex than this framework entertains. This paper describes the assumptions and formulation of the conventional framework for the two major classes of psychophysical methods (single- and dual-presentation methods) and presents various lines of empirical evidence that the framework is inconsistent with. An alternative framework is then described and shown to account for all the characteristics that the conventional framework regards as anomalies. This alternative process model explicitly separates the sensory, decisional, and response components of performance and represents them via parameters whose estimation characterizes the corresponding processes. Retrospective and prospective evidence of the validity of the alternative framework is also presented. A formal analysis also reveals that some psychophysical methods and response formats are unsuitable for separation of the three components of observed performance. Recommendations are thus given regarding practices that should be avoided and those that should be followed to ensure interpretability of the psychometric function, or descriptors (detection threshold, difference limen, point of subjective equality, etc.) obtained with shortcut methods that do not require estimation of psychometric functions.
Cognitive Aging and Tests of Rationality
Authors: Park Sanghyuk , Davis-Stober Clintin P. , Snyder Hope K. , Messner William , Regenwetter Michel
Published: December 2019

We investigated whether older adults are more likely than younger adults to violate a foundational property of rational decision making, the axiom of transitive preference. Our experiment consisted of two groups, older (ages 60-75; 21 participants) and younger (ages 18-30; 20 participants) adults. We used Bayesian model selection to investigate whether individuals were better described via (transitive) weak order-based decision strategies or (possibly intransitive) lexicographic semiorder decision strategies. We found weak evidence for the hypothesis that older adults violate transitivity at a higher rate than younger adults. At the same time, a hierarchical Bayesian analysis suggests that, in this study, the distribution of decision strategies across individuals is similar for both older and younger adults.
Non-locality Correlation in Two Driven Qubits Inside an Open Coherent Cavity: Trace Norm Distance and Maximum Bell Function
Authors: Mohamed A. -B. A. , Eleuch H. , Ooi C. H. Raymond
Published: December 2019

We analytically investigate two separated qubits inside an open cavity field. The cavity is initially prepared in a superposition coherent state. The non-locality correlations [including trace norm measurement induced non-locality, maximal Bell-correlation, and concurrence entanglement] of the two qubits are explored. It is shown that, the generated non-locality correlations crucially depend on the decay and the initial coherence intensity of the cavity field. The enhancement of the initial coherence intensity and its superposition leads to increasing the generated non-locality correlations. The phenomena of sudden birth and death entanglement are found.
Using road class as a replacement for predicted motorized traffic flow in spatial network models of cycling
Authors: Chan Eric Yin Cheung , Cooper Crispin H. V.
Published: December 2019

Recent years have seen renewed policy interest in urban cycling due to the negative impacts of motorized traffic, obesity and emissions. Simulating bicycle mode share and flows can help decide where to build new infrastructure for maximum impact, though modelling budgets are limited. The four step model used for vehicles is not typically used for this task as, aside from the expense of use, it is designed around too-large zone sizes and a simplified network. Alternative approaches are based on aggregate statistics or spatial network analysis, the latter being necessary to create a model sufficiently sensitive to infrastructure location, although still requiring considerable modelling effort due to the need to simulate motor vehicle flows in order to account for the effect of motorized traffic in disincentivising cycling. The model presented uses an existing spatial network analysis methodology on an unsimplified network, but simplifies the analysis by substituting explicit prediction of motorized traffic flow with an alternative based on road classification. The method offers a large reduction in modelling effort, but nonetheless gives model correlation with actual cycling flows (R2 = 0.85) broadly comparable to a previous model with motorized traffic fully simulated (R2 = 0.78).
Sideroflexin 4 affects Fe-S cluster biogenesis, iron metabolism, mitochondrial respiration and heme biosynthetic enzymes
Authors: Paul Bibbin T. , Tesfay Lia , Winkler C. R. , Torti Frank M. , Torti Suzy V.
Published: December 2019

Sideroflexin4 (SFXN4) is a member of a family of nuclear-encoded mitochondrial proteins. Rare germline mutations in SFXN4 lead to phenotypic characteristics of mitochondrial disease including impaired mitochondrial respiration and hematopoetic abnormalities. We sought to explore the function of this protein. We show that knockout of SFXN4 has profound effects on Fe-S cluster formation. This in turn diminishes mitochondrial respiratory chain complexes and mitochondrial respiration and causes a shift to glycolytic metabolism. SFXN4 knockdown reduces the stability and activity of cellular Fe-S proteins, affects iron metabolism by influencing the cytosolic aconitase–IRP1 switch, redistributes iron from the cytosol to mitochondria, and impacts heme synthesis by reducing levels of ferrochelatase and inhibiting translation of ALAS2. We conclude that SFXN4 is essential for normal functioning of mitochondria, is necessary for Fe-S cluster biogenesis and iron homeostasis, and plays a critical role in mitochondrial respiration and synthesis of heme.
The prognostic significance of hematogones and CD34+ myeloblasts in bone marrow for adult B-cell lymphoblastic leukemia without minimal residual disease
Authors: Liao Hongyan , Zheng Qin , Jin Yongmei , Chozom Tashi , Zhu Ying , Liu Li , Jiang Nenggang
Published: December 2019

This study was aimed to dissect the prognostic significances of hematogones and CD34+ myeloblasts in bone marrow for adult B-cell acute lymphoblastic leukemia(ALL) without minimal residual disease(MRD) after the induction chemotherapy cycle. A total of 113 ALL patients who have received standardized chemotherapy cycle were analyzed. Cases that were not remission after induction chemotherapy or have received stem cell transplantation were excluded. Flow cytometry was used to quantify the levels of hematogones and CD34+ myeloblasts in bone marrow aspirations, and the patients were grouped according to the levels of these two precursor cell types. The long-term relapse-free survival(RFS) and recovery of peripheral blood cells of each group after induction chemotherapy were compared. The results indicated that, after induction chemotherapy, patients with hematogones ≥0.1% have a significantly longer remission period than patients with hematogones <0.1% (p = 0.001). Meanwhile, the level of hematogones was positively associated with the recovery of both hemoglobin and platelet in peripheral blood, while CD34+ myeloblasts level is irrelevant to the recovery of Hb and PLT in peripheral blood, level of hematogones and long-term prognosis. This study confirmed hematogones level after induction chemotherapy can be used as a prognostic factor for ALL without MRD. It is more applicable for evaluation prognosis than CD34+ myeloblasts.