bluuebunny/crossref_metadata_2025 huggingface dataset:
Postembryonic development and male paedomorphosis in Osedax (Siboglinidae, Annelida)
Authors: Worsaae Katrine , Rouan Alice , Seaver Elaine , Miyamoto Norio , Tilic Ekin
Published: March 2024

Most species of the bone-devouring marine annelid, Osedax, display distinct sexual dimorphism with macroscopic sedentary females rooted in bones and free-living microscopic dwarf males. The paedomorphic male resembles the non-feeding metatrochophore larva in size, presence of eight pairs of chaetae, and a head ciliation potentially representing a residual prototroch. The male development may thus uniquely reiterate and validate the theoretical heterochrony process “progenesis”, which suggests that an accelerated sexual maturation and early arrest of somatic growth can lead to a miniaturized and paedomorphic adult. In this study, we describe the postembryonic larval and juvenile organogenesis of Osedax japonicus to test for a potential synchronous arrest of somatic growth during male development. Five postembryonic stages could be distinguished, resembling day one to five in the larval development at 10°C: (0D) first cleavage of fertilized eggs (embryos undergo unequal spiral cleavage), (1D) pre-trochophore, with apical organ, (2D) early trochophore, + prototroch, brain, circumesophageal connectives and subesophageal commissure, (3D) trochophore, + telotroch, four ventral nerves, (4D) early metatrochophore, + protonephridia, dorsal and terminal sensory organs, (5D) metatrochophore, + two ventral paratrochs, mid-ventral nerve, posterior trunk commissure, two dorsal nerves; competent for metamorphosis. The larval development largely mirrors that of other lecithotrophic annelid larvae but does not show continuous chaetogenesis or full gut development. Additionally, O. japonicus larvae exhibit an unpaired, mid-dorsal, sensory organ. Female individuals shed their larval traits during metamorphosis and continue organogenesis (including circulatory system) and extensive growth for 2–3 weeks before developing oocytes. In contrast, males develop sperm within a day of metamorphosis and display a synchronous metamorphic arrest in neural and muscular development, retaining a large portion of larval features post metamorphosis. Our findings hereby substantiate male miniaturization in Osedax to be the outcome of an early and synchronous offset of somatic development, fitting the theoretical process “progenesis”. This may be the first compelling morpho-developmental exemplification of a progenetic origin of a microscopic body plan. The presented morphological staging system will further serve as a framework for future examination of molecular patterns and pathways determining Osedax development.
Effects and safety of Ginkgo biloba on depression: a systematic review and meta-analysis
Authors: Lin Jingya , Sun Xiaojing , Yang Lingli
Published: March 2024

Background: Because depression is a major factor contributing to the global disease burden, we tried to analyze the effects and safety of Ginkgo biloba (GKB) on patients with depression.

Methods: We conducted a literature search for articles published between January 2002 and May 2022 in seven online databases (PubMed, Scopus, Embase, Google Scholar, Web of Sciences, Cochrane Library, and China National Knowledge Infrastructure). A systematic literature review and meta-analysis were performed to compare the effects and safety of GKB on patients with depression, including subjective and objective indicators of depression evaluation.

Results: In total, 21 eligible articles with nine indicators among 2074 patients were included. Several outcomes showed a difference, and the GKB group had better results than the control group, including the Hamilton Depression Scale (HAMD), after taking GKB for 4 weeks (MD = −2.86, 95%CI [−4.27, −1.46], p < 0.01), 6 weeks (mean difference (MD) = −3.36, 95%CI [−4.05, −2.67], p < 0.01), and 8 weeks (MD = −4.58, 95% CI [−6.11, −3.05], p < 0.01), modified Barthel index (MBI) (MD = 14.86, 95%CI [12.07, 17.64], p < 0.01), modified Edinburgh-Scandinavian stroke scale (MESSS) (MD = −4.57, 95%CI [−6.34, −2.79], p < 0.01), brain-derived neurotrophic factor (BDNF) (MD = 16.35, 95%CI [7.34, 25.36], p < 0.01), 5-hydroxytryptamine (5-HT) (MD = 4.57, 95%CI [3.08, 6.05], p < 0.01), and clinical efficacy (risk ratio, RR = 1.24, 95%CI [1.17, 1.32], p < 0.01). However, there were no differences in adverse events between GKB and controls.

Conclusion: In conclusion, the main finding was that patients treated with GKB had better MBI, MESSS, BDNF, 5-HT, and HAMD values after 4 weeks, 6 weeks, and 8 weeks than the control group. GKB might reduce the risk of depression or depressive symptoms with safe clinical efficacy.

Systematic Review Registration: identifier (INPLASY2023100052)
Traditional Tibetan medicine: therapeutic potential in lung diseases
Authors: Li Canlin , Li Yuan , Huang Xi , Li Si , Sangji Kangzhuo , Gu Rui
Published: March 2024

Lung diseases have become a major threat to human health worldwide. Despite advances in treatment and intervention in recent years, effective drugs are still lacking for many lung diseases. As a traditional natural medicine, Tibetan medicine has had a long history of medicinal use in ethnic minority areas, and from ancient times to the present, it has a good effect on the treatment of lung diseases and has attracted more and more attention. In this review, a total of 586 Tibetan medicines were compiled through literature research of 25 classical works on Tibetan medicine, drug standards, and some Chinese and English databases. Among them, 33 Tibetan medicines have been studied to show their effectiveness in treating lung diseases. To investigate the uses of these Tibetan medicines in greater depth, we have reviewed the ethnomedicinal, phytochemical and pharmacological properties of the four commonly used Tibetan medicines for lung diseases (rhodiola, gentian, sea buckthorn, liexiang dujuan) and the five most frequently used Tibetan medicines (safflower, licorice, sandalwood, costus, myrobalan). It is expected to provide some reference for the development of new drugs of lung diseases in the future.
Black Americans suppress emotions when prejudice is believed to stem from shared ignorance
Authors: Chaney Kimberly E. , Pham Minh Duc , Cipollina Rebecca
Published: March 2024

Past research examining lay theories of the origins of prejudice has focused on white Americans and has not considered how Black Americans’ lay theories of prejudice may impact emotion regulation following discrimination. Across three samples of Black Americans (N = 419), the present research examined relationships between endorsement of two lay theories of prejudice origins (1, beliefs that prejudice stems from shared social ignorance and 2, that prejudice stems from malice). Stronger beliefs that prejudice stems from shared ignorance were associated with greater expression suppression following experiences of racial discrimination (studies 1b and 2), which was, in turn, associated with psychological distress (study 2). By centering the beliefs and experiences of Black Americans in response to discrimination events, the present research has implications for understanding how emotion regulation following racial discrimination is impacted by marginalized groups’ conceptualizations of prejudice. Future research should investigate how these factors impact health disparities.
Specificity of tilt illusion reduction through perceptual learning
Authors: Jeong Na-Ri , Han Seungmin , Choi Hoon
Published: March 2024

Human perceptual ability can be improved by perceptual learning through repeated exposure or training. Perceptual learning studies have focused on achieving accurate perception of stimuli by improving perceptual sensitivity. However, eliminating illusions can also be one of the ways of accurate perception. To determine whether the illusion can be attenuated by perceptual learning, the current study used a tilt illusion where the orientation of the grating presented in the center (central grating) was misperceived because of the orientation of the grating presented in the periphery (surrounding grating). In Experiment 1, participants were trained either in the illusion training condition, in which they trained with illusory stimuli presenting both surrounding and central gratings together, or in the control training condition, where only the central grating was presented. The results confirmed that the tilt illusion was reduced only in the illusion training condition. Experiment 2 tested the transfer effect of learning, which is not often observed in perceptual learning. During training, the orientation of the surrounding grating was fixed to see whether the elimination of the illusion also occurred in the surrounding grating with an orientation that was not used during training. A decrease in the illusion was found only in the case of a surrounding grating with trained orientations, and not in the case of surrounding gratings with untrained orientations. These results suggest that the reduction in tilt illusion through training is due to perceptual learning.
Tislelizumab versus sorafenib as first-line treatment for advanced hepatocellular carcinoma in China: a cost-effectiveness analysis
Authors: Zheng Zhiwei , Lin Yuxuan , Cai Hongfu
Published: March 2024

Objective

The goal of this study is to compare the cost-effectiveness of tislelizumab and sorafenib as first-line treatment for advanced hepatocellular carcinoma in China.

Methods

A comprehensive cost-effectiveness analysis was undertaken within the framework of a partitioned survival model to accurately gage the incremental cost-effectiveness ratio (ICER) of tislelizumab compared to sorafenib. The model incorporated relevant clinical data and all survival rates were from RATIONALE-301 trials. The stability of the partitioned survival model was assessed by performing one-way and two-way sensitivity analyses.

Results

The total cost incurred for the tislelizumab treatment was $16181.24, whereas the sorafenib was $14306.87. The tislelizumab regimen resulted in a significant increase of 0.18 quality-adjusted life years (QALYs) and an extra cost of $1874.37 as compared to chemotherapy. The ICER was $10413.17 per QALY, which was found to be below the willingness-to-pay (WTP) threshold of $37304.34/QALY. The results of the sensitivity analysis found that no fluctuations in any of the factors affected our results, even when these parameters fluctuated.

Conclusion

Tislelizumab appears to be a cost-effective first-line treatment for advanced hepatocellular carcinoma when compared to sorafenib in China. These findings can inform decision-making processes regarding the selection of the most cost-effective treatment option for advanced hepatocellular carcinoma.
Life course socioeconomic status, chronic pain, and the mediating role of allostatic load: findings from the midlife in the United States
Authors: Liang Yunlong
Published: March 2024

Introduction

Low socioeconomic status (SES) has been linked to chronic pain (CP); however, the mechanisms by which SES over the life course influences downstream CP outcomes remain unclear.

Methods

This study utilizes data from the Midlife in the United States (MIDUS) survey, a prospective sample of community-dwelling individuals (N=781), to investigate the chain of risk additive model of SES in relation to CP. Additionally, the study examines the mediating role of allostatic load (AL) in the relationship between life course SES and CP. Confirmatory factor analysis was employed to capture the multidimensionality of life course SES and path analysis was used to examine the direct and indirect effects on CP. AL was computed by quartile-based summation and by latent class analysis.

Results

Results indicated lower SES in MIDUS 2 was associated with greater high-interference CP odds in MIDUS 3 (OR=1.069, 95% CI=1.006-1.136, P < 0.05) and no association was found between distal SES and levels of CP interference. Similarly, no significant relationship was observed between SES and the number of CP locations. Additionally, no additive effects of SES were found, and AL did not present mediation effects on the association between life course SES and CP.

Discussion

The present study emphasizes the importance of directly proximal effects of SES on CP, underscoring the need for equitable distribution of health resources and the implementation of policies focused on diminishing socioeconomic inequalities. Further research is needed to examine alternative pathways by which proximal SES impact CP.
Arterial spin labeled perfusion MRI for the assessment of radiation-treated meningiomas
Authors: Manning Paul , Srinivas Shanmukha , Bolar Divya S. , Rajaratnam Matthew K. , Piccioni David E. , McDonald Carrie R. , Hattangadi-Gluth Jona A. , Farid Nikdokht
Published: March 2024

Purpose

Conventional contrast-enhanced MRI is currently the primary imaging technique used to evaluate radiation treatment response in meningiomas. However, newer perfusion-weighted MRI techniques, such as 3D pseudocontinuous arterial spin labeling (3D pCASL) MRI, capture physiologic information beyond the structural information provided by conventional MRI and may provide additional complementary treatment response information. The purpose of this study is to assess 3D pCASL for the evaluation of radiation-treated meningiomas.

Methods

Twenty patients with meningioma treated with surgical resection followed by radiation, or by radiation alone, were included in this retrospective single-institution study. Patients were evaluated with 3D pCASL and conventional contrast-enhanced MRI before and after radiation (median follow up 6.5 months). Maximum pre- and post-radiation ASL normalized cerebral blood flow (ASL-nCBF) was measured within each meningioma and radiation-treated meningioma (or residual resected and radiated meningioma), and the contrast-enhancing area was measured for each meningioma. Wilcoxon signed-rank tests were used to compare pre- and post-radiation ASL-nCBF and pre- and post-radiation area.

Results

All treated meningiomas demonstrated decreased ASL-nCBF following radiation (p < 0.001). Meningioma contrast-enhancing area also decreased after radiation (p = 0.008) but only for approximately half of the meningiomas (9), while half (10) remained stable. A larger effect size (Wilcoxon signed-rank effect size) was seen for ASL-nCBF measurements (r = 0.877) compared to contrast-enhanced area measurements (r = 0.597).

Conclusions

ASL perfusion may provide complementary treatment response information in radiation-treated meningiomas. This complementary information could aid clinical decision-making and provide an additional endpoint for clinical trials.
Developing outdoor spaces for work and study—an explorative place-making process
Authors: Jansson Märit , Mårtensson Fredrika , Vogel Nina
Published: March 2024

Introduction

The development of outdoor spaces for work and study is part of a larger transition toward sustainable communities, which can take advantage of more flexible ways of organizing everyday life. Governance processes supported by physical spatial changes have the potential to bring together various actors and experts for local development. The aim of this study was to explore the possibilities of developing outdoor spaces for work and study in a collaborative process.

Methods

The study involved an upper secondary school, a local government administration, local businesses and research. The process took place in a South-Swedish small town and included developing outdoor areas for tasks traditionally carried out indoors, participatory workshops and meetings followed up through questionnaires and interviews.

Results

Overall, the introduction of outdoor places was positively evaluated, but engagement varied across actors and over time, and a number of obstacles and challenges in the process were identified.

Discussion

The study showed how vital it is to anchor ideas for place-making locally and having key persons in leading positions with allocated time to support the process. It also indicates how decisive spatial changes can be and how important it is that any physical intervention becomes an integrated part of a wider local process in order to make an imprint on local life and pedagogical practice.
Retrospective analysis of the incidence and outcome of late acute and chronic graft-versus-host disease—an analysis from transplant centers across Europe
Authors: Langer Ronja , Lelas Antonela , Rittenschober Michael , Piekarska Agnieszka , Sadowska-Klasa Alicja , Sabol Ivan , Desnica Lana , Greinix Hildegard , Dickinson Anne , Inngjerdingen Marit , Lawitschka Anita , Vrhovac Radovan , Pulanic Drazen , Güneş Sibel , Klein Stefan , Moritz Middeke Jan , Grube Matthias , Edinger Matthias , Herr Wolfgang , Wolff Daniel
Published: March 2024

Introduction

Chronic graft-versus-host disease (cGvHD) is a serious late complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT).

Methods

This multicenter analysis determined the cumulative incidence (CI) of cGvHD and late acute GvHD (laGvHD) and its impact on transplantation-related mortality (TRM), relapse (R), and overall survival (OS) in 317 patients [296 adults, 21 pediatrics (<12 years of age)] who underwent their first allo-HSCT in 2017.

Results

The CI of laGvHD was 10.5% in adults and 4.8% in pediatrics, and the CI of cGvHD was 43.0% in all adult transplant patients and 50.2% in the adult at-risk cohort at the study end. The onset of cGvHD was de novo in 42.0% of patients, quiescent in 52.1%, and progressive in 5.9%. In adults, prophylactic use of antithymocyte globulin or posttransplant cyclophosphamide was associated with a significantly lower incidence of cGvHD (28.7%) vs. standard prophylaxis with calcineurin inhibitors (30.6%) and methotrexate/mycophenolate mofetil (58.4%) (all p < 0.01). TRM was significantly higher in patients with aGvHD (31.8%) vs. cGvHD (12.6%) and no GvHD (6.3%) (all p = 0.0001). OS in the adult at-risk cohort was significantly higher in patients with cGvHD (78.9%) vs. without (66.2%; p = 0.0022; HR 0.48) due to a significantly lower relapse rate (cGvHD: 14.5%; without cGvHD: 27.2%; p = 0.00016, HR 0.41). OS was also significantly higher in patients with mild (80.0%) and moderate (79.2%) cGvHD vs. without cGvHD (66.2%), excluding severe cGvHD (72.7%) (all p = 0.0214).

Discussion

The negative impact of severe cGvHD on OS suggests a focus on prevention of severe forms is warranted to improve survival and quality of life.
The high energy X-ray probe (HEX-P): bringing the cosmic X-ray background into focus
Authors: Civano F. , Zhao X. , Boorman P. G. , Marchesi S. , Ananna T. , Creech S. , Chen C.-T. , Hickox R. C. , Stern D. , Madsen K. , García J. A. , Silver R. , Aird J. , Alexander D. M. , Baloković M. , Brandt W. N. , Buchner J. , Gandhi P. , Kammoun E. , LaMassa S. , Lanzuisi G. , Merloni A. , Moretti A. , Nandra K. , Nardini E. , Pizzetti A. , Puccetti S. , Pfeifle R. W. , Ricci C. , Spiga D. , Torres-Albà N.
Published: March 2024

Since the discovery of the cosmic X-ray background (CXB), astronomers have strived to understand the accreting supermassive black holes (SMBHs) contributing to its peak in the 10–40 keV band. Existing soft X-ray telescopes could study this population up to only 10 keV, and, while NuSTAR (focusing on 3–24 keV) made great progress, it also left significant uncertainties in characterizing the hard X-ray population, crucial for calibrating current population synthesis models. This paper presents an in-depth analysis of simulations of two extragalactic surveys (deep and wide) with the High-Energy X-ray Probe (HEX-P), each observed for 2 Ms. Applying established source detection techniques, we show that HEX-P surveys will reach a flux of ∼10−15 erg s−1 cm−2 in the 10–40 keV band, an order of magnitude fainter than current NuSTAR surveys. With the large sample of new hard X-ray detected sources (∼2000), we showcase HEX-P’s ability to resolve more than 80% of the CXB up to 40 keV into individual sources. The expected precision of HEX-P’s resolved background measurement will allow us to distinguish between population synthesis models of SMBH growth. HEX-P will leverage accurate broadband (0.5–40 keV) spectral analysis and the combination of soft and hard X-ray colors to provide obscuration constraints even for the fainter sources, with the overall objective of measuring the Compton-thick fraction. With unprecedented sensitivity in the 10–40 keV band, HEX-P will explore the hard X-ray emission from AGN to flux limits never reached before, thus expanding the parameter space for serendipitous discoveries. Consequently, it is plausible that new models will be needed to capture the population HEX-P will unveil.
Training zones in competitive swimming: a biophysical approach
Authors: Fernandes Ricardo J. , Carvalho Diogo D. , Figueiredo Pedro
Published: March 2024

Since swimming performance depends on both physical conditioning and technical proficiency, training zones should be built based on physiology and biomechanics inputs to dispose of structured and effective training programs. This paper presents a zone-based swimming training, supported by the oxygen uptake (V˙O2) kinetics at low, moderate, heavy, severe and extreme intensities concurrently with lactate and heart rate values. Since technique is vital for efficiently moving through the water, upper limbs frequency and length should also be targeted during the workouts. The index of coordination was also added to our proposal since upper limbs synchronization is a key technical factor. To better establish and characterize a wide range of swimming intensities, the training methods and corresponding contents that better fit each training zone will be suggested. It will be shown that when under/at the anaerobic threshold (at low-to-moderate intensities), swimmers are at homeostasis and can maintain stable internal and external load indicators. However, above that boundary (at heavy and severe intensities), the physiological stable state is no longer observed and the anaerobic metabolism starts contributing significantly, with a technical degradation being more evident when performing near/at the V˙O2max intensity. Then, when performing above aerobic power, on typical anaerobic intensities, V˙O2 kinetics presents a very evident fast rise, ending abruptly due to exhaustion caused by muscle acidosis. This overall knowledge allows advancing toward more objective training programs and highlights the importance of systematic training control and swimmers' evaluation and advice.
The future of the sugarcane industry in Fiji: climatic, non-climatic stressors, and opportunities for transformation
Authors: Medina Hidalgo Daniela , Mallette Angela , Nadir Suhayl , Kumar Salesh
Published: March 2024

This study explores the complex dynamics of Fiji’s sugarcane industry, shedding light on the challenges it faces and the implications for agricultural system resilience and sustainability. The primary aim of the study was to investigate the relationship between climatic and non-climatic stressors and farmers’ decisions to abandon sugarcane farming. A total of 900 farmers were surveyed, which corresponds to approximately 7.5% of the sugarcane farming population in the country. Farmers were sampled using a stratified disproportional random sampling technique, by surveying 300 farmers from each of the three primary sugarcane mill regions in Fiji (Labasa, Lautoka, and Rarawai). Results depict an aging farming population with small land holdings, and limited income and agricultural diversification. While only 4% of farmers are currently considering abandoning sugarcane farming, a further 17.9% are uncertain about their future in the industry. The majority of farmers have been impacted by climate hazards, primarily tropical cyclones and floods, but the degree to which these hazards have affected livelihoods has had an effect on farmers’ willingness to remain in the industry and on the extent to which they implement reactive or anticipatory responses to hazards. The study highlights the need for coordinated efforts to support sustainable intensification and planned adaptation, especially in the face of climate-induced vulnerabilities, this should be a priority as the sector continues to navigate sustainability issues. Additionally, it underscores the importance of transforming the industry to address both climatic and non-climatic stressors. Ultimately, this research offers valuable insights into the multifaceted issues confronting Fiji’s sugarcane sector, and the broader agricultural systems it represents.
Green synthesis of silver and iron nano composites using aqueous extract of zanthoxylum armatum seeds and their application for removal of acid black 234 dye
Authors: Bashir Nadia , Gulzar Saba , Shad Salma
Published: March 2024

Green nanotechnology has gained attraction in recent years due to the growing awareness of the environmental and health risks associated with traditional methods of nanomaterial synthesis. In the present study, nanocomposite (NCs) of silver and Iron were prepared using Zanthoxylum Armatum seeds aqueous extract which acts as a reducing, stabilizing, and capping agent. The synthesized NCs were characterized using UV/Vis Spectroscopy, powder X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), and EDX. The UV/Vis spectroscopy analysis of the NCs revealed the presence of a surface plasmonic resonance band occurring at 420 nm. Examination of the NCs through SEM demonstrated that they exhibited a nearly spherical morphology, with an average particle diameter measuring 54.8 nm. The crystalline nature of these NCs was verified through X-ray diffraction (XRD), and the calculation of crystallite size using the Scherrer-Debye equation yielded a value of 12.6 nm. The adsorption ability of newly synthesized nanocomposites was investigated against Acid Black 234 Dye. The results showed that a 0.5 g of NCs dose at pH 4 removed 99.3% of 10 mg/L of Acid Black 234 Dye within 60 min. Based on the findings of this research, it can be inferred that the that Ag-Fe NCs synthesized from Zanthoxylum Armatum seeds aqueous extract hold significant potential for addressing environmental pollution caused by Acid Black 234 Dye. The NCs were used as adsorbent for the removal of Acid Black 234 dye from the wastewater sample and showed 98% removal of dye from the commercial sample within 60 min. In this context, the research highlights that the environmentally friendly synthesis of Ag-Fe nanocrystals (Ag-Fe NCs) using Zanthoxylum Armatum as a mediator offers an efficient and cost-effective solution for mitigating environmental pollution.
Physicochemical properties, mechanism of action of lycopene and its application in poultry and ruminant production
Authors: Long Yong , Paengkoum Siwaporn , Lu Shengyong , Niu Xinran , Thongpea Sorasak , Taethaisong Nittaya , Han Yong , Paengkoum Pramote
Published: March 2024

Lycopene is a kind of natural carotenoid that could achieve antioxidant, anti-cancer, lipid-lowering and immune-improving effects by up-regulating or down-regulating genes related to antioxidant, anti-cancer, lipid-lowering and immunity. Furthermore, lycopene is natural, pollution-free, and has no toxic side effects. The application of lycopene in animal production has shown that it could improve livestock production performance, slaughter performance, immunity, antioxidant capacity, intestinal health, and meat quality. Therefore, lycopene as a new type of feed additive, has broader application prospects in many antibiotic-forbidden environments. This article serves as a reference for the use of lycopene as a health feed additive in animal production by going over its physical and chemical characteristics, antioxidant, lipid-lowering, anti-cancer, and application in animal production.
Descriptive Anatomy of the Porcine Ventral Abdominal Wall as a Basis for Training Ventral Hernia Repair Techniques
Authors: Vierstraete Maaike , Van Der Vekens Nicky , Beckers Roel , Renard Yohann , Muysoms Filip
Published: March 2024

Background: In recent times there has been a surge in innovative techniques concerning complex abdominal wall surgery. The availability of simulation models for comprehensive training and skill set development remains limited.

Methods: Cadaveric dissections of the porcine abdominal wall were conducted to assess the suitability of anesthetized porcine models for training in both minimally invasive and open surgical procedures.

Results: The panniculus carnosus, a typical muscular layer in mammals, is the outermost layer covering the anterolateral abdominal wall. Beneath it, there are four main pairs of abdominal wall muscles, mirroring the human anatomy. The rectus abdominis muscle runs straight along the linea alba and is surrounded by the rectus sheath, which is formed by the fusion of the lateral abdominal wall muscles and differs along the different regions of abdominal wall. The orientation of the muscle fibers in the lateral abdominal wall muscles, i.e., musculus obliquus externus, internus and transversus, is comparable to human anatomy. Although the transition lines between their muscular and aponeurotic part differ to some extent. Relevant for the adoption of surgical techniques, the transversus abdominis muscle is well-developed and resembles a bell curve shape as it transitions from its muscular to aponeurotic part.

Conclusion: Despite minor differences in abdominal wall anatomy between pigs and humans, the porcine model provides a high level of fidelity in terms of both anatomical features and the development of skill sets relevant to hernia surgery.
Updates in Skin Cancer in Transplant Recipients and Immunosuppressed Patients: Review of the 2022–2023 Scientific Symposium of the International Immunosuppression and Transplant Skin Cancer Collaborative
Authors: Pisano Catherine , Leitenberger Justin J. , Pugliano-Mauro Melissa , Carroll Bryan T.
Published: March 2024

The International Immunosuppression and Transplant Skin Cancer Collaborative (ITSCC) and its European counterpart, Skin Care in Organ Transplant Patients-Europe (SCOPE) are comprised of physicians, surgeons, and scientist who perform integrative collaborative research focused on cutaneous malignancies that arise in solid organ transplant recipients (SOTR) and patients with other forms of long-term immunosuppression. In October 2022, ITSCC held its biennial 4-day scientific symposium in Essex, Massachusetts. This meeting was attended by members of both ITSCC and SCOPE and consisted of specialists including Mohs micrographic and dermatologic oncology surgeons, medical dermatologists, transplant dermatologists, transplant surgeons, and transplant physicians. During this symposium scientific workshop groups focusing on consensus standards for case reporting of retrospective series for invasive squamous cell carcinoma (SCC), defining immunosuppressed patient status for cohort reporting, development of multi-institutional registry for reporting rare tumors, and development of a KERACON clinical trial of interventions after a SOTRs’ first cutaneous SCC were developed. The majority of the symposium focused on presentation of the most up to date research in cutaneous malignancy in SOTR and immunosuppressed patients with specific focus on chemoprevention, immunosuppression regimens, immunotherapy in SOTRs, spatial transcriptomics, and the development of cutaneous tumor registries. Here, we present a summary of the most impactful scientific updates presented at the 2022 ITSCC symposium.
The Effect of Long-Term Crop Rotations for the Soil Carbon Sequestration Rate Potential and Cereal Yield
Authors: Skinulienė Lina , Marcinkevičienė Aušra , Dorelis Mindaugas , Bogužas Vaclovas
Published: March 2024

Depending on the type of agricultural use and applied crop rotation, soil organic carbon accumulation may depend, which can lead to less CO2 fixation in the global carbon cycle. Less is known about organic carbon emissions in different crop production systems (cereals, grasses) using different agrotechnologies. There is a lack of more detailed studies on the influence of carbon content in the soil on plant productivity, as well as the links between the physical properties of the soil and the absorption, viability, and emission of greenhouse gases (GHG) from mineral fertilizers. The aim of this study is to estimate the long-term effect of soil organic carbon sequestration potential in different crop rotations. The greatest potential for organic carbon sequestration is Norfolk-type crop rotation, where crops that reduce soil fertility are replaced by crops that increase soil fertility every year. Soil carbon sequestration potential was significantly higher (46.72%) compared with continuous black fallow and significantly higher from 27.70 to 14.19% compared with field with row crops and cereal crop rotations, respectively, intensive crop rotation saturated with intermediate crops. In terms of carbon sequestration, it is most effective to keep perennial grasses for one year while the soil is still full of undecomposed cereal straw from the previous crop. Black fallow without manure fertilization, compared to crop rotation, reduces the amount of organic carbon in the soil up to two times, the carbon management index by 2–5 times, and poses the greatest risk to the potential of carbon sequestration in agriculture.
Enhancing Fruit Fly Detection in Complex Backgrounds Using Transformer Architecture with Step Attention Mechanism
Authors: Zhang Lexin , Chen Kuiheng , Zheng Liping , Liao Xuwei , Lu Feiyu , Li Yilun , Cui Yuzhuo , Wu Yaze , Song Yihong , Yan Shuo
Published: March 2024

This study introduces a novel high-accuracy fruit fly detection model based on the Transformer structure, specifically aimed at addressing the unique challenges in fruit fly detection such as identification of small targets and accurate localization against complex backgrounds. By integrating a step attention mechanism and a cross-loss function, this model significantly enhances the recognition and localization of fruit flies within complex backgrounds, particularly improving the model’s effectiveness in handling small-sized targets and its adaptability under varying environmental conditions. Experimental results demonstrate that the model achieves a precision of 0.96, a recall rate of 0.95, an accuracy of 0.95, and an F1-score of 0.95 on the fruit fly detection task, significantly outperforming leading object detection models such as YOLOv8 and DETR. Specifically, this research delves into and optimizes for challenges faced in fruit fly detection, such as recognition issues under significant light variation, small target size, and complex backgrounds. Through ablation experiments comparing different data augmentation techniques and model configurations, the critical contributions of the step attention mechanism and cross-loss function to enhancing model performance under these complex conditions are further validated. These achievements not only highlight the innovativeness and effectiveness of the proposed method, but also provide robust technical support for solving practical fruit fly detection problems in real-world applications, paving new paths for future research in object detection technology.
Electrolyzed Oxidizing Water in Controlling Pseudomonas syringae pv. tomato in Tomato Crops
Authors: Mexicano Lilia , Medina Tarsicio , Mexicano Adriana , Carmona Jesús-Carlos
Published: March 2024

Bacterial speck disease in tomato crops is caused by Pseudomonas syringae pv. tomato. Chemical control is mainly used for the control of phytopathogens, which carries a risk for both human health and the environment, making it necessary to search for environmentally friendly alternatives, such as the use of electrolyzed water. In the present study, preventive treatments were applied to tomato plants of the saladette variety. The treatments employed were electrolyzed oxidizing water (EOW), electrolyzed reduced water (ERW), a commercial bactericide (Kasumin), and untreated plants as the base control. During the vegetative stage, the disease severity, stem diameter, number of leaves, and number of clusters were determined. In addition, the soluble solids (°Brix), titratable acidity (TA), pH, color, polar and equatorial diameter, weight, and weight loss of the harvested fruit were determined. According to the results, the lowest severity was obtained in the plants treated with oxidizing water, achieving results similar to those achieved with the commercial bactericide Kasumin. It can be concluded that oxidizing water can be applied to tomato crops since its effect is similar to that of Kasumin, but without affecting the growth and development of the crop. Moreover, it is environmentally friendly.
Impact of Winter Cover Crops on Total and Microbial Carbon and Nitrogen in Black Soil
Authors: Li Yubo , Zhu Qin , Zhang Yang , Liu Shuang , Wang Xiaoting , Wang Enheng
Published: March 2024

Winter cover crops have been shown to promote the accumulation of microbial biomass carbon and nitrogen, enhance nutrient cycling, reduce erosion, improve ecosystem stability, etc. In the black soil area of Northeast China, Triticum aestivum L., Medicago sativa L., Vicia villosa Roth., Triticum aestivum L. and Medicago sativa L. mixed planting, Triticum aestivum L. and Vicia villosa Roth. mixed planting, and winter fallow fields (CK) were selected to investigate the effects of winter cover crops on soil total carbon and nitrogen and microbial biomass carbon and nitrogen. The results showed that (1) after seasonal freeze-thaw, the rate of change in SOC (−2.49~6.50%), TN (−1.54~5.44%), and C/N (−1.18~1.16%) was less than that in SMBC (−80.91~−58.33%), SMBN (−65.03~332.22%), and SMBC/SMBN (−45.52~−90.03%); (2) winter cover crops not only alleviated the negative effects of seasonal freeze-thaw, which reduces SMBC and qMBC, but also increased SMBN and qMBN; (3) there was an extremely significant (p < 0.01) positive correlation between SOC and TN, a significant (p < 0.05) negative correlation between SMBC and SMBN, and there was no significant correlation between SOC and SMBC or between TN and SMBN; (4) alkali-hydrolysable nitrogen had the greatest impact on SOC and TN, while the soil’s saturation degree had the greatest impact on SMBC and SMBN; and (5) the Triticum aestivum L. monoculture was the most effective in conserving soil microbial carbon and nitrogen. In conclusion, winter cover crops can mitigate the reduction in soil microbial biomass carbon caused by seasonal freeze-thaw and also increase the soil microbial nitrogen content in the black soil region of Northeast China, of which Triticum aestivum L. monoculture showed the best performance.
Oliviculture and Viticulture Crop Byproducts Use for Peat Partial Substitution for Carnation Production
Authors: Chrysargyris Antonios , Xylia Panayiota , Tzortzakis Nikolaos
Published: March 2024

The intensive cultivation of olive trees and grapevines in the Mediterranean region not only results in large yields but also generate wastes, with high restrictions on their impact on people’s well-being and the environment. The current study sought to investigate the potential use of olive-mill waste (OW), grape-mill waste (GW) and their mixtures (OW + GW) at different levels (0%, 5%, 10% and 20% v/v) for partial peat substitution in the production of carnation (Dianthus caryophyllus L.) plants. The presence of OW, GW and OW + GW wastes raised the pH, the electrical conductivity, the content of organic matter and mineral content in substrate mixtures, while they decreased the total porosity and the available free air. The use of OW had more negative impacts than GW, while the OW + GW mixture alleviated, to some extent, the negative OW impacts. The use of high levels of residues decreased plant growth, chlorophyll content and mineral accumulation in plant tissue due to inappropriate growing media properties. The increased OW presence caused oxidative stress to the plants, as verified by the increased malondialdehyde and hydrogen peroxide content. This resulted in an upsurge in the total phenolics. However, GW presence did not impact any oxidative stress. It can be suggested that 10% OW, 10% GW or 20% OW + GW can be used in growing media, as they resulted in suitable plant growth. To ensure sufficient yields, nevertheless, the growing media’s characteristics also need to be enhanced.
Enhancing Soil Health and Plant Growth through Microbial Fertilizers: Mechanisms, Benefits, and Sustainable Agricultural Practices
Authors: Wei Xinpei , Xie Benkang , Wan Chu , Song Renfeng , Zhong Wanru , Xin Shuquan , Song Kai
Published: March 2024

Soil microorganisms play a crucial role in maintaining the structure and function of soil ecosystems. This study aims to explore the effects of microbial fertilizers on improving soil physicochemical properties and promoting plant growth. The results show that the application of microbial fertilizers significantly increases the richness of soil microorganisms, maintains soil microecological balance, and effectively improves the soil environment. Through various secondary metabolites, proteins, and mucilage secreted by the developing plant root system, microbial fertilizers recruit specific fungal microorganisms. These microorganisms, by binding soil particles with their extracellular polysaccharides and entwining them, fix the soil, enhance the stability of soil aggregates, and ameliorate soil compaction. Moreover, after the application of microbial fertilizers, the enriched soil microbial community not only promotes the plant’s absorption and utilization of key elements such as nitrogen (N), phosphorus (P), and potassium (K), thereby increasing fruit yield and quality, but also competes with pathogens and induces systemic resistance in plants, effectively warding off pathogenic invasions. This study highlights the potential and importance of microbial fertilizers in promoting sustainable agricultural development, offering new strategies and perspectives for future agricultural production.
The Role of Carbon Nanotubes in Improving Drought Tolerance via Upregulation of the Physiological Processes of Peanut Plants Grown in Sandy Soils
Authors: Bakry Bakry A. , Sadak Mervat Sh. , Al Ashkar Nagla M. , Ibrahim Omar M. , Okla Mohammad K. , El-Tahan Amira M.
Published: March 2024

Drought stress is an important challenge to global food security and agricultural output, and dramatic and rapid climate change has made the problem worse, causing unexpected impacts on the growth, development, and yield of different plants. Understanding the biochemical, ecological, and physiological reactions to these pressures is essential for improved management. Carbon materials’ impacts on plants subjected to different stresses are still poorly studied. Thus, this study was carried out investigate the feasibility of applying carbon nanotubes (CNTs) (0, 20, and 40 mg/L) as a foliar treatment for mitigating the effect of water stress (100%, 75%, and 50% irrigation water, IW) on peanut plants growing in sandy soil through assessments of growth and productivity and some physiological and biochemical measurements. Exposure of peanuts to decreased irrigation water led to significant decreases in growth, yield, photosynthetic pigments, indole acetic acid (IAA), and some nutritional components in peanut seeds, but increased levels of osmolytes such as total soluble carbohydrates (TSS) and proline, in addition to free amino acids and phenolics. However, foliar spraying with CNTs could ameliorate the impacts of decreased irrigation water on growth and production via enhancing the studied physiological parameters, such as photosynthetic pigments, IAA, osmolytes, and phenolics. Furthermore, the application of carbon nanotubes improved the nutrient contents, as expressed by the oil yield, protein yield, total carbohydrates, antioxidant activities (DPPH), B-carotene, lycopene, and flavonoids in peanut seeds, either under normal or water stress conditions. The higher level of CNTs (40 mg/L) was more effective than the lower one (20 mg/L) at increasing the above-mentioned parameters. In conclusion, foliar treatment with carbon nanotubes has the ability to enhance peanut drought tolerance and increase its growth and productivity under sandy soil conditions.
Pro-Environmental Transformation of the Equine Sector—Facilitators and Challenges
Authors: Hedenborg Susanna , Kronborg Mathilde , Sätre Anna , Radmann Aage , Torell Palmquist Gabriella , Andersson Petra
Published: March 2024

To improve horse welfare and ensure a sustainable equestrian future, we need to understand human behavior in relation to the challenges of the sector. The purpose of this paper is to map and analyze how individuals within the equine sector in Sweden and Norway define the environmental challenges they are faced with and how these are related to questions about horse welfare. A mixed-methods parallel design was used. The data consist of survey answers and semi-structured interviews. The survey, responded to by 697 Swedish and Norwegian participants, ensured statistical validity and power through a sample size calculation yielding approximately 385 participants. To deepen the understanding, 36 semi structured interviews with Swedish and Norwegian interviewees were conducted. An analysis of convergencies and divergencies between the data sets provided robust insights into the perceptions and behaviors within the equine sector in Sweden and Norway. The findings show that the equine sector has cultivated a stronger environmental commitment over the last 15 years (Svala, 2008). However, many participants express a perceived lack of influence on this transformation. The COM-B model (Michie, Van Stralen & West, 2011; Michie, Atkins & West, 2014) and previous research on ‘thinking structures on climate delay’ (Wormbs & Wolrath, 2023) are used to interpret the data. The analysis indicates that there is an overall capacity for change, and that skills and knowledge exist, but some individuals desire more information and a deeper understanding of the issues at hand. Higher barriers to change were found in the opportunity component, where physical constraints such as location, resources, and time seem challenging for individual actors to influence. Economic factors are also identified as impediments to transformation. Cultural norms related to orderliness within stables, although not directly addressing ecological nor ethical challenges, might serve as a foundation for promoting environmental initiatives that will also improve horse welfare.
Integrated Metagenomic and Metabolomic Analysis on Two Competing Mussels, Mytella strigata and Perna viridis, in China
Authors: Zuo Chenxia , Ma Peizhen , Ma Xiaojie , Zhu Yi , Yan Shaojing , Zhang Zhen
Published: March 2024

Biological invasion is a primary direct driver of biodiversity loss. Recently, owing to exploitation competition with an invasive mussel, Mytella strigata (Hanley, 1843), there has been a drastic decrease in the population of native Perna viridis (Linnaeus, 1758) in several western Pacific regions. In the present study, intestinal microbiota, metabolome, and key digestive enzyme activities were compared between the two competing mussels, M. strigata and P. viridis, to elucidate the differences in intestinal microbiota and metabolic points. We observed that Proteobacteria, Firmicutes, and Bacteroidota were the three predominant bacterial phyla in the two species. The relative abundance of Bacteroidota related to carbohydrate-degrading ability was significantly higher in M. strigata than in P. viridis. Compared to P. viridis, different metabolites including maltose and trehalose were enriched in M. strigata. Lastly, higher carbohydrases activities of alpha-amylase, cellulase, and xylanase were observed in M. strigata than in P. viridis. These differences might play an important role in the adaptation process of M. strigata to the new environment. This study provides important basic knowledge for investigating the competition between M. strigata and P. viridis in terms of food resources utilization.