bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhancing risk stratification models in localized prostate cancer by novel validated tissue biomarkers
Authors: Olah Csilla , Mairinger Fabian , Wessolly Michael , Joniau Steven , Spahn Martin , Kruithof-de Julio Marianna , Hadaschik Boris , Soós Aron , Nyirády Péter , Győrffy Balázs , Reis Henning , Szarvas Tibor
Published: November 2024

Background

Localized prostate cancer (PCa) is a largely heterogeneous disease regarding its clinical behavior. Current risk stratification relies on clinicopathological parameters and distinguishing between indolent and aggressive cases remains challenging. To improve risk stratification, we aimed to identify new prognostic markers for PCa.

Methods

We performed an in silico analysis on publicly available PCa transcriptome datasets. The top 20 prognostic genes were assessed in PCa tissue samples of our institutional cohort (n = 92) using the NanoString nCounter technology. The three most promising candidates were further assessed by immunohistochemistry (IHC) in an institutional (n = 121) and an independent validation cohort from the EMPACT consortium (n = 199). Cancer-specific survival (CSS) and progression-free survival (PFS) were used as endpoints.

Results

Our in silico analysis identified 113 prognostic genes. The prognostic values of seven of the top 20 genes were confirmed in our institutional radical prostatectomy (RPE) cohort. Low CENPO, P2RX5, ABCC5 as well as high ASF1B, NCAPH, UBE2C, and ZWINT gene expressions were associated with shorter CSS. IHC analysis confirmed the significant associations between NCAPH and UBE2C staining and worse CSS. In the external validation cohort, higher NCAPH and ZWINT protein expressions were associated with shorter PFS. The combination of the newly identified tissue protein markers improved standard risk stratification models, such as D’Amico, CAPRA, and Cambridge prognostic groups.

Conclusions

We identified and validated high tissue levels of NCAPH, UBE2C, and ZWINT as novel prognostic risk factors in clinically localized PCa patients. The use of these markers can improve routinely used risk estimation models.
The contribution of attention-deficit/hyperactivity disorder polygenic load to metabolic and cardiovascular health outcomes: a large-scale population and sibling study
Authors: Du Rietz Ebba , Xie Tian , Wang Rujia , Cheesman Rosa , Garcia-Argibay Miguel , Dong Zihan , Zhang Jia , Niebuur Jacobien , Vos Melissa , Snieder Harold , Larsson Henrik , Hartman Catharina A.
Published: November 2024

Emerging evidence suggests that ADHD is associated with increased risk for metabolic and cardiovascular (cardiometabolic) diseases. However, an understanding of the mechanisms underlying these associations is still limited. In this study we estimated the associations of polygenic scores (PGS) for ADHD with several cardiometabolic diseases and biomarkers. Furthermore, we investigated to what extent the PGS effect was influenced by direct and indirect genetic effects (i.e., shared familial effects). We derived ADHD-PGS in 50,768 individuals aged 18–90 years from the Dutch Lifelines Cohort study. Using generalised estimating equations, we estimated the association of PGS with cardiometabolic diseases, derived from self-report and several biomarkers measured during a physical examination. We additionally ran within-sibling PGS analyses, using fixed effects models, to disentangle direct effects of individuals’ own ADHD genetic risk from confounding due to indirect genetic effects of relatives, as well as population stratification. We found that higher ADHD-PGS were statistically significantly associated with several cardiometabolic diseases (R-squared [R2] range = 0.03–0.50%) and biomarkers (related to inflammation, blood pressure, lipid metabolism, amongst others) (R2 range = 0.01–0.16%) (P < 0.05). Adjustment for shared familial factors attenuated the associations between ADHD-PGS and cardiometabolic outcomes (on average 56% effect size reduction), and significant associations only remained for metabolic disease. Overall our findings suggest that increased genetic liability for ADHD confers a small but significant risk increase for cardiometabolic health outcomes in adulthood. These associations were observable in the general population, even in individuals without ADHD diagnosis, and were partly explained by familial factors shared among siblings.
FXR deficiency induced ferroptosis via modulation of the CBP-dependent p53 acetylation to suppress breast cancer growth and metastasis
Authors: Huang Ping , Zhao Han , Dai Hua , Li Jinying , Pan Xiafang , Pan Wentian , Xia Chunhua , Liu Fanglan
Published: November 2024

Farnesoid X receptor (NR1H4/FXR) functions as a scavenger of lipid peroxide products and drives the proliferation and metastasis of various cancers. However, the underlying molecular mechanisms remain poorly understood. In our study, we found that the expression levels of FXR, vimentin and SLC7A11 were significantly higher in breast cancer tissues, particularly in metastatic cancer tissues compared to non-metastatic ones. Furthermore, the increased FXR expression was positively correlated with vimentin and SLC7A11 in clinical tumor specimens. In addition, a high level of FXR correlated with poor prognosis in patients with breast cancer. Both Z-Guggulsterone (Z-GS), as a pharmacological inhibitor of FXR, and silencing FXR curbed proliferation and migration of breast cancer cells by promoting ferroptosis. Notably, our results showed that FXR competitively bound to CREB-binding protein (CBP) to suppress the interaction between p53 and CBP in the nucleus, and thus prevented p53 acetylation at lys382, which was essential for upregulating the expression of SLC7A11. Conversely, FXR knockdown increased the interaction between p53 and CBP and promoted p53 acetylation, which ultimately led to facilitating ferroptosis in breast cancer cells. More importantly, we also found that Z-GS inhibited TGF-β1-induced tumor growth and metastasis of breast cancer primarily through ferroptosis via regulating CBP-dependent p53 acetylation in nude mice. In conclusion, the FXR was first reported as a tumor promoter that enhanced the proliferation and metastasis of breast cancer cells through regulating CBP-dependent p53 K382 acetylation. It proposes that FXR may serve as a potential therapeutic target for the treatment of breast cancer.
Bringing atom probe tomography to transmission electron microscopes
Authors: Da Costa Gerald , Castro Celia , Normand Antoine , Vaudolon Charly , Zakirov Aidar , Macchi Juan , Ilhami Mohammed , Edalati Kaveh , Vurpillot François , Lefebvre Williams
Published: November 2024

For the purpose of enhancing the structural insights within the three-dimensional composition fields revealed by atom probe tomography, correlative microscopy approaches, combining (scanning) transmission electron microscopy with atom probe tomography, have emerged and demonstrated their relevance. To push the boundaries further and facilitate a more comprehensive analysis of nanoscale matter by coupling numerous two- or three-dimensional datasets, there is an increasing interest in combining transmission electron microscopy and atom probe tomography into a unified instrument. This study presents the tangible outcome of an instrumental endeavour aimed at integrating atom probe tomography into a commercial transmission electron microscope. The resulting instrument demonstrates the feasibility of combining in situ 3D reconstructions of composition fields with the detailed structural analysis afforded by transmission electron microscopy. This study shows a promising approach for converging these two important nanoscale microscopy techniques.
Extreme electron–hole drag and negative mobility in the Dirac plasma of graphene
Authors: Ponomarenko Leonid A. , Principi Alessandro , Niblett Andy D. , Wang Wendong , Gorbachev Roman V. , Kumaravadivel Piranavan , Berdyugin Alexey I. , Ermakov Alexey V. , Slizovskiy Sergey , Watanabe Kenji , Taniguchi Takashi , Ge Qi , Fal’ko Vladimir I. , Eaves Laurence , Greenaway Mark T. , Geim Andre K.
Published: November 2024

Coulomb drag between adjacent electron and hole gases has attracted considerable attention, being studied in various two-dimensional systems, including semiconductor and graphene heterostructures. Here we report measurements of electron–hole drag in the Planckian plasma that develops in monolayer graphene in the vicinity of its Dirac point above liquid-nitrogen temperatures. The frequent electron–hole scattering forces minority carriers to move against the applied electric field due to the drag induced by majority carriers. This unidirectional transport of electrons and holes results in nominally negative mobility for the minority carriers. The electron–hole drag is found to be strongest near room temperature, despite being notably affected by phonon scattering. Our findings provide better understanding of the transport properties of charge-neutral graphene, reveal limits on its hydrodynamic description, and also offer insight into quantum-critical systems in general.
Dichotomous outcomes of TNFR1 and TNFR2 signaling in NK cell-mediated immune responses during inflammation
Authors: McCulloch Timothy R. , Rossi Gustavo R. , Alim Louisa , Lam Pui Yeng , Wong Joshua K. M. , Coleborn Elaina , Kumari Snehlata , Keane Colm , Kueh Andrew J. , Herold Marco J. , Wilhelm Christoph , Knolle Percy A. , Kane Lawrence , Wells Timothy J. , Souza-Fonseca-Guimaraes Fernando
Published: November 2024

Natural killer (NK) cell function is regulated by a balance of activating and inhibitory signals. Tumor necrosis factor (TNF) is an inflammatory cytokine ubiquitous across homeostasis and disease, yet its role in regulation of NK cells remains unclear. Here, we find upregulation of the immune checkpoint protein, T cell immunoglobulin and mucin domain 3 (Tim3), is a biomarker of TNF signaling in NK cells during Salmonella Typhimurium infection. In mice with conditional deficiency of either TNF receptor 1 (TNFR1) or TNF receptor 2 (TNFR2) in NK cells, we find TNFR1 limits bacterial clearance whereas TNFR2 promotes it. Mechanistically, via single cell RNA sequencing we find that both TNFR1 and TNFR2 induce the upregulation of Tim3, while TNFR1 accelerates NK cell death but TNFR2 promotes NK cell accumulation and effector function. Our study thus highlights the complex interplay of TNF-based regulation of NK cells by the two TNF receptors during inflammation.
An interaction network of inner centriole proteins organised by POC1A-POC1B heterodimer crosslinks ensures centriolar integrity
Authors: Sala Cornelia , Würtz Martin , Atorino Enrico Salvatore , Neuner Annett , Partscht Patrick , Hoffmann Thomas , Eustermann Sebastian , Schiebel Elmar
Published: November 2024

Centriole integrity, vital for cilia formation and chromosome segregation, is crucial for human health. The inner scaffold within the centriole lumen composed of the proteins POC1B, POC5 and FAM161A is key to this integrity. Here, we provide an understanding of the function of inner scaffold proteins. We demonstrate the importance of an interaction network organised by POC1A-POC1B heterodimers within the centriole lumen, where the WD40 domain of POC1B localises close to the centriole wall, while the POC5-interacting WD40 of POC1A resides in the centriole lumen. The POC1A-POC5 interaction and POC5 tetramerization are essential for inner scaffold formation and centriole stability. The microtubule binding proteins FAM161A and MDM1 by binding to POC1A-POC1B, likely positioning the POC5 tetramer near the centriole wall. Disruption of POC1A or POC1B leads to centriole microtubule defects and deletion of both genes causes centriole disintegration. These findings provide insights into organisation and function of the inner scaffold.
Ultrafast upconversion superfluorescence with a sub-2.5 ns lifetime at room temperature
Authors: Zhou Mengwei , Huang Ping , Shang Xiaoying , Zhang Ruihuan , Zhang Wen , Shao Zhiqing , Zhang Shuo , Zheng Wei , Chen Xueyuan
Published: November 2024

Photon upconversion through lanthanide-doped nanoparticles is of great significance for various applications. However, the current development of upconversion nanoparticles is hindered by the low quantum efficiency and long radiative lifetimes of lanthanide ions, restricting their applications in time-dependent nanophotonics. Herein, we report ultrafast upconversion superfluorescence with a lifetime of sub-2.5 ns in lanthanide-doped nanoparticles at room temperature. Upon excitation with an 800-nm fs-pulsed laser, we achieve a large number (N = 912) of correlated dipoles in Nd3+-concentrated nanoparticles, resulting in collective coherent emission with two orders of magnitude amplification in intensity and more than three orders of magnitude improvement in the radiative decay rate. Furthermore, we demonstrate that the control of excitation power and emitting sample length enables the lifetime manipulation of upconversion emission in a wide range from μs to sub-ns, accompanied by the typical superfluorescence signature of Burnham-Chiao ringing. These findings may benefit applications in many advanced technologies such as quantum counting and high-speed super-resolution bioimaging.
Assessment of fuzzy logic to enhance species distribution modelling of two cryptic wood boring beetle species in Australia
Authors: Li Xingyu , Emery Robert N. , Coupland Grey T. , Ren Yonglin , McKirdy Simon J.
Published: November 2024

Fuzzy logic presents a promising approach for Species Distribution Modelling by generating a value that can be used for comparative purposes termed ‘environmental favourability’. In contrast to ‘presence probability’, ‘environmental favourability’ remains robust regardless of species prevalence. This characteristic facilitates effective comparisons across species with varying levels of prevalence. In this study, presence probability was predicted using three commonly used Species Distribution Models: Generalised Linear Model, Generalised Additive Modelling, and Boosted Regression Trees for two beetle species, Euwallacea fornicatus and Euwallacea perbrevis in Australia. Fuzzy logic was then employed to derive environmental favourability values based on these models. Additionally, Maxent modelling was included to compare prediction outputs and facilitate a comprehensive analysis. Model performance was evaluated using standard metrics (Area under the receiver operating characteristic curve, True statistical skill, Correct classification rate), as well as Hosmer-Lemeshow test. The research explored fuzzy similarity, fuzzy intersection and potential biotic interaction of these closely related borers, and revealed a favourable distribution pattern for Euwallacea fornicatus across Australia. This study supports the efficacy of fuzzy logic in Species Distribution Modelling and highlights the value of environmental favourability function in enhancing the comparative analysis of the geographical relationship across species. This approach offers a more nuanced perspective on Species Distribution Modelling.
Gaze-based detection of mind wandering during audio-guided panorama viewing
Authors: Kwok Tiffany C. K. , Kiefer Peter , Schinazi Victor R. , Hoelscher Christoph , Raubal Martin
Published: November 2024

Unlike classic audio guides, intelligent audio guides can detect users’ level of attention and help them regain focus. In this paper, we investigate the detection of mind wandering (MW) from eye movements in a use case with a long focus distance. We present a novel MW annotation method for combined audio-visual stimuli and collect annotated MW data for the use case of audio-guided city panorama viewing. In two studies, MW classifiers are trained and validated, which are able to successfully detect MW in a 1-s time window. In study 1 (n = 27), MW classifiers from gaze features with and without eye vergence are trained (area under the curve of at least 0.80). We then re-validate the classifier with unseen data (study 2, n = 31) that are annotated using a memory task and find a positive correlation (repeated measure correlation = 0.49, p < 0.001) between incorrect quiz answering and the percentage of time users spent mind wandering. Overall, this paper contributes significant new knowledge on the detection of MW from gaze for use cases with audio-visual stimuli.
High-intensity interval training is an effective exercise mode to maintain normal blood pressure during pregnancy: a randomized control trial
Authors: Sun Junjiang , Radzimiński Łukasz , Santos-Rocha Rita , Szumilewicz Anna
Published: November 2024

Pregnant women are more susceptible to high blood pressure (BP) than the general adult population; therefore, all means of preventing this condition should be considered. High-intensity interval training (HIIT) is effective in this regard in the general population, but there is a lack of evidence of its effectiveness during pregnancy. This study aimed to compare an 8-week HIIT program to self-performed moderate-to-vigorous physical activity among pregnant women by evaluating changes in BP after a maximal progressive cardiorespiratory exercise test (CPET) performed at pre-intervention and post-intervention time points. A total of 54 Caucasian women in uncomplicated, singleton pregnancies (age 32 ± 4 years, 22 ± 4 weeks of gestation; M ± SD) with normal BP values completed the interventions. The experimental (HIIT) group (n = 34) completed an online supervised HIIT program consisting of three sessions per week and supplemented by an educational class once per week. Participants in the education (EDU) group (n = 20) attended an educational class once per week and were encouraged to perform moderate-to-vigorous physical activity (PA) on their own. Pre- and post-intervention, all women underwent a CPET on a cycle ergometer with a respiratory gas analyzer. On the day of the CPET, maternal systolic and diastolic BP (mmHg) was measured at rest (before the CPET) and approximately 60 min after the CPET using an electronic BP monitor. Identical CPET and BP measurement protocols were employed for both the HIIT and EDU groups at the pre- and post-intervention time points. Pre-intervention, the HIIT and EDU groups both showed a decrease in systolic and diastolic BP after the CPET, though only the change in systolic BP was statistically significant (HIIT group: p = 0.01; EDU group: p = 0.001). Post-intervention, there were no significant differences in either group between resting and post-CPET BP. There were significant post-intervention differences in VO2peak (p < 0.001) and HRmax (p = 0.002) between the HIIT and EDU groups. From pre- to post-intervention, the EDU and HIIT groups both showed decreases in resting systolic or diastolic BP; there was a significant difference in systolic BP in the EDU group (p = 0.005) and a significant difference in diastolic BP in the HIIT group (p = 0.03). Both groups maintained normal BP values throughout the experiment. However, HIIT, in addition to maintaining normotension, improved cardiorespiratory fitness in pregnant women. It seems that both supervised HIIT and self-performed moderate-to-vigorous PA can be recommended as strategies to prevent BP disorders during pregnancy. More studies are needed to confirm our findings.

Trial registration The full study protocol was registered in ClinicalTrials.gov (NCT05009433).
Redistribution of PU.1 partner transcription factor RUNX1 binding secures cell survival during leukemogenesis
Authors: Bender Alexander , Boydere Füsun , Jayavelu Ashok Kumar , Tibello Alessia , König Thorsten , Aleth Hanna , Meyer zu Hörste Gerd , Vogl Thomas , Rosenbauer Frank
Published: November 2024

Transcription factors (TFs) orchestrating lineage-development often control genes required for cellular survival. However, it is not well understood how cells survive when such TFs are lost, for example in cancer. PU.1 is an essential TF for myeloid fate, and mice with downregulated PU.1 levels develop acute myeloid leukemia (AML). Combining a multi-omics approach with a functional genetic screen, we reveal that PU.1-downregulated cells fundamentally change their survival control from cytokine-driven pathways to overexpression of an autophagy-predominated stem cell gene program, for which we also find evidence in human AML. Control of this program involves redirected chromatin occupancy of the PU.1 partner TF Runx1 to a lineage-inappropriate binding site repertoire. Hence, genomic reallocation of TF binding upon loss of a partner TF can act as a pro-oncogenic failsafe mechanism by sustaining cell survival during leukemogenesis.
Taylor dispersion analysis as a tool for size measurement of PAMAM dendrimers: the effect of generation, functionality and pH
Authors: Chhabria Vikesh , Forbes Robert , Zhou Zhengyuan
Published: November 2024

TDA demonstrates accurate Rh with a low standard deviation, for half-generations, and highlights conformational changes in response to ionization and variations in salt concentration.
Unraveling the effect of reagent vibrational excitation on the scattering mechanism of the benchmark H + H2 → H2 + H hydrogen exchange reaction in the coupled 12E′ ground electronic manifold
Authors: Sahoo Jayakrushna , Goswami Sugata , Mahapatra S.
Published: November 2024

A theoretical study of how vibrational excitation affects differential cross sections in the hydrogen exchange reaction, revealing unique forward-scattering dynamics and a new correlation among scattering angle, product rotation and its helicity.
Conformational dynamics of the pyrene excimer
Authors: Parolin Giovanni , Garain Bidhan Chandra , Mukherjee Saikat , Granucci Giovanni , Corni Stefano , Barbatti Mario
Published: November 2024

We characterized the S1 state PES of the pyrene dimer, revealing key excimer conformations. A rapid shift to a stacked-twisted form dominates the excimer's structure and fluorescence.
23.2% efficient low band gap perovskite solar cells with cyanogen management
Authors: Perera W. Hashini K. , Webb Thomas , Xu Yuliang , Zhu Jingwei , Zhou Yundong , Trindade Gustavo F. , Masteghin Mateus G. , Harvey Steven P. , Jenatsch Sandra , Dai Linjie , Sathasivam Sanjayan , Macdonald Thomas J. , Hinder Steven J. , Zhao Yunlong , Stranks Samuel D. , Zhao Dewei , Zhang Wei , Jayawardena K. D. G. Imalka , Haque Saif A. , Silva S. Ravi P.
Published: November 2024

The role of thiocyanates in minimising organohalide diffusion into PEDOT:PSS whilst accelerating device degradation is identified and a route towards improving both device efficiency and stability is demonstrated.
Occurrences of allergenicity to banana pathogenesis-related-10 (PR10) protein variants
Authors: Suhaimi Ahmad Husaini , Rajendram Arullthevan , Khaidizar Fiqri Dizar , Mir Patricia , Pulido-Lucas Elisa , Quirce Santiago , Pedrosa Maria , Rodriguez-Perez Rosa , Al-Idrus Aisyafaznim
Published: November 2024

Banana allergy alert! PR10 proteins enhance plant resistance to pathogens and drought, but are also linked to pollen food syndrome. We found two banana PR10 protein variants recognised by 26.6% of allergic patients.
Enhancing sustainable energy production through co-polyamide membranes for improved pressure-retarded osmosis performance and environmental impact: synthesis and life cycle analysis
Authors: Aghapour Aktij Sadegh , Dadashi Firouzjaei Mostafa , Pilevar Mohsen , Asad Asad , Rahimpour Ahmad , Elliott Mark , Soares João B. P. , Sadrzadeh Mohtada
Published: November 2024

This study investigates the application of co-polyamide (Co-PA) membranes in the pressure-retarded osmosis (PRO) process, highlighting their enhanced performance and sustainability, as shown by life cycle assessment.
AuCu bimetallic nanocluster-modified titania nanotubes for photoelectrochemical water splitting: composition-dependent atomic arrangement and activity
Authors: Chinnappa Chinnabathini Vana , Ag Karthick Raj , Nguyen Thi Hong Trang , Zarkua Zviadi , Abbas Imran , Hoang Thi Hang , Lievens Peter , Grandjean Didier , Verbruggen Sammy W. , Janssens Ewald
Published: November 2024

The relationship between the atomic-level structure and the photoelectrochemical water splitting reaction of AuxCu1−x nanoalloys on titania nanotubes photoanodes was investigated.
Site-selective decarbonylative [4 + 2] annulation of carboxylic acids with terminal alkynes by C–C/C–H activation strategy and cluster catalysis
Authors: Cen Mengjie , Ma Xinyue , Yang Xi , Zhang Shangshang , Liu Long , Szostak Michal , Chen Tieqiao
Published: November 2024

A highly site-selective decarbonylative [4 + 2] cyclization of carboxylic acids with terminal alkynes forming naphthalenes is enabled by palladium cluster catalysis.
Annulated carbocyclic gallylene and bis-gallylene with two-coordinated Ga(i) atoms
Authors: Merschel Arne , Heda Shkelqim , Vishnevskiy Yury V. , Neumann Beate , Stammler Hans-Georg , Ghadwal Rajendra S.
Published: November 2024

The first carbocyclic gallylene [(ADC)2Ga(GaI2)] and bis-gallylene [(ADC)Ga]2 (ADC = PhC{N(Dipp)C}2; Dipp = 2,6-iPr2C6H3) featuring a central C4Ga2 ring annulated between two 1,3-imidazole rings are prepared by KC8 reductions of [(ADC)GaI2]2.
Active droplet driven by collective chemotaxis
Authors: Carlsson Christian , Gao Tong
Published: November 2024

Chemical concentration fields and flow patterns inside and outside of a spherical active droplet powered by collective chemotaxis.
Coherent integration method for high‐speed target detection using angular inverse rotation transform
Authors: Wang Le , Tao Haihong , Yang Aodi , Yang Fusen
Published: November 2024

High‐speed target often induces severe across range unit problem in the long‐time coherent integration (LTCI). This paper designates the bottom‐right corner of the 2‐D compressed signal as the coordinate system origin. It establishes a novel angular inverse rotation transform that accurately corrects target's trajectory to the final location and achieves signal energy accumulation. Numerical simulation experiments and real‐world measured data confirm the effectiveness of the proposed method.
Design and verification of monitoring system of DC microgrid based on Ethernet communication
Authors: Zhang Lirong , Bao Xianwen
Published: November 2024

Real‐time acquisition of microgrid (MG) operation data and remote control play a crucial role in the safe and stable operation of MG. A design scheme of monitoring system is proposed for the wind/photovoltaic/energy storage islanded direct current MG. The core controllers used in direct current MG system are programmable logic controller and digital signal processor. The monitoring system mainly adopts Ethernet communication, together with serial port communication mode Recommend Standard 232 (RS232) and Recommended Standard 485 (RS485) communication modes. A heterogeneous networking is built with controllers and data display instruments. Different monitoring interfaces are designed, the important information can be real‐time detected, collected and displayed. The multi‐energy and multi‐load dispatching operation control are realized according to scheduling operation plan. The parameters of the inverter can be adjusted, and the output voltage waveform and sinusoidal pulse width modulation waveform of the inverter can be measured. The communication of the proposed monitoring system is reliable, flexible and expandable, and easy to realize remote operation control. Moreover, the detection and control functions can be extended further. Through experiments, the effective control and monitoring of the designed monitoring system is verified, and the intelligent management is realized.
First discovery and confirmation of planetary nebula candidates from AI and deep learning techniques applied to VPHAS+ survey data
Authors: Li Yushan , Parker Quentin , Jia Peng
Published: November 2024

Context. We have developed tools based on deep learning and artificial intelligence (AI) to search extant narrow-band wide-field Hα surveys of the Galactic Plane for elusive planetary nebulae (PNe) hidden in dense star fields towards the Galactic centre. They are faint, low-surface-brightness, usually resolved sources, which had not discovered by previous automatic searches that depend on photometric data for point-like sources. These sources are very challenging to locate by traditional visual inspection in such crowded fields and many have been missed. We have successfully adopted a novel ‘Swin-Transformer’ AI algorithm, which we describe in detail in the preceding Techniques paper (Paper I).

Aims. Here, we present preliminary results from our first spectroscopic follow-up run for 31 top-quality PN candidates found by the algorithm from the high-resolution Hα survey VPHAS+. This survey has not yet undergone extensive manual, systematic searching.

Methods. Our candidate PNe were observed with the SpUpNIC spectrograph on the 1.9 m telescope at the South African Astronomical Observatory (SAAO) in June 2023. We performed standard IRAF spectroscopic reduction, followed by our normal HASH PN identification and classification procedures.

Results. Our reduced spectra confirmed that these candidates include 22 true, likely, and possible PNe (70.97%), 3 emission-line galaxies, 2 emission-line stars, 2 late-type star contaminants, and 2 other Hα sources including a newly identified detached fragment of supernova remnants (SNRs) RCW 84. We present the imaging and spectral data of these candidates and a preliminary analysis of their properties. These data provide strong input for evaluating and refining the behaviour of the AI algorithm when searching for PNe in wide-field Hα surveys.
RETRACTED: Sturgen diseases risks in closed water supply facilities and possible approaches to pharmacotherapy and prevention
Authors: Basankina Viktoriya , Kaloshkina Inna , Basankin Aleksey , Semenenko Marina , Semenenko Ksenia
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Pathophysiological aspects of phospholipid metabolism in rats exposed to acute hypoxia of different etiologies
Authors: Kanaeva Elena , Pavlova Olga , Gulenko Olga , Bukareva Olga , Moskvitina Polina , Khan Azizuddin
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Characteristic of Kalmyk servicing bulls of different genotypes
Authors: Chimidova Nadezhda , Moiseikina Ludmila , Ubushieva Victoria , Ubushieva Altana , Khakhlinov Arslang , Radchikov Vasiliy
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Quality evaluation of progeny of the sterlet Acipenser ruthenus (sterlet) obtained offspring
Authors: Ponomareva Elena , Firsova Angelina , Sorokina Marina , Kovalenko Matvey , Belaya Maria , Viet Thuy Nguyen
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Study of the lipid peroxidation products dynamics in the blood and liver of different aged rats in experimentally induced dyslipoproteinemia
Authors: Tulaeva Olga , Pavlova Olga , Gulenko Olga , Bukareva Olga , Zhelonkin Nikolai
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Opportunities to increase livestock production efficiency by developing agricultural services in Uzbekistan
Authors: Khurramov Azizbek , Tulakov Ulugbek , Soliyev Abdumalik , Djalilova Malika , Khurramova Madina , Ortikov Shavkat , Shaymardanov Abror
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: The necessity of developing mobile applications for people with disabilities
Authors: Farmanov Erkin , Radjabov Odil , Davronov Istamkhuja , Yuldashev Kamol , Sharipov Bekzod , Ibragimov Nutfillo
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Development of an information system to improve the efficiency of custom production
Authors: Orlov Vasiliy , Tynchenko Vadim , Kukartseva Svetlana
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Prospects for the transformation of video game media rhetoric in terms of the influence of artificial intelligence
Authors: Tarasov Aleksey , Belyaev Dmitry
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Quality of transportation service of transport and logistic company
Authors: Nikiforova Guzel , Karyakina Julia
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Organizational and technological solutions for planning the construction of buildings of social nature
Authors: Zilberova Inna , Fedorovskaya Albina , Novoselova Irina , Petrov Konstantin , Mazanov Nikita
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Innovation management in construction companies in the context of macroeconomic volatility
Authors: Barmuta Karine , Malkhasyan Anastasia , Dymchenko Olga , Fateeva Olga
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Development of the Industrial Internet of things in Russia and China: Economic and legal aspects
Authors: Gorodnova Natalia , Shablova Yelena
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: The information system for the selection of a study direction and skills development in the field of information security
Authors: Aidinyan Andrey , Tsvetkova Olga
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Creating an original technique for identifying objects in video streams
Authors: Alexandrov Islam , Ruslantsev Andrei , Aslanov Tagirbek , Gorelov Viktor
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Study of RFID technology action phenomena with consideration of directional factor
Authors: Khamzaev Dilshod
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Algorithm for reconstruction images obtained by a holographic camera based on the Fast Fourier Transform
Authors: Yudin Nikolay , Zinovev Mikhail , Kuznetsov Vladimir , Kulesh Maxim , Podzyvalov Sergey , Slyunko Elena , Heimbuch Henry , Baalbaki Hussein
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: International practice and cooperation in the interests of sustainable development of the BRICS countries
Authors: Suchilina Anna , Korneeva Elena , Krayneva Raisa , Parmanasova Aisulu
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Business models and digital technologies in international companies’ management
Authors: Abrosimova Vera , Tarasenko Aleksandr
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Computer modelling of socio-economic dynamics: A framework for evaluating the demographic development
Authors: Kupriyanova Marina , Evdokimova Elena , Bannikov Sergey
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Digital volunteering of student youth: Awareness and willingness to participate
Authors: Eflova Maria , Maximova Olga , Garipova Regina
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: The effective organization of customer service technology in freight transportation sector
Authors: Kobulov Jamshid , Barotov Jamshid , Samiev Farrukh , Fayzullaev Gaybullo
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Digital management in the context of self-regulation of society: Prospects and ways of development
Authors: Shumilina Anastasia , Antsiferova Natalia , Ilyasov Denis , Konovalov Alexander
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Innovative pedagogical strategies for the formation of intercultural competence
Authors: Kondratieva Irina , Malina Nadezhda , Rogacheva Tatiana
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: The role of higher education in the formation of soft skill competencies among workers in the service industry
Authors: Komarnitsky Igor , Provotorina Valeria , Momzhieva Anastasia
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: The influence of parents on the physiological and psychological development and behavior of children
Authors: Samatova Abiba , Koshmatova Zhyldyz , Zhoroeva Rahat , Nazhimidinova Asylkan , Abdibayitova Apiza
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Greening of higher education: Global thinking, local initiative
Authors: Djoldosheva Tamara , Mottaeva Angela , Pervukhina Irina , Vidrevich Marina , Berezhnova Elena
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Economic development of the Kyrgyz republic: An input-output analysis across three development phases
Authors: Kadyraliev Almaz , uulu Bakhtyiar Bakas , Makeeva Meerim , Osmonova Bermer , Mottaeva Angela
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Competence formation objective assessment as the method to control student's independent work
Authors: Aydarkin Eugeniy , Kundupyan Oxana , Starostin Artem , Fomina Anna , Kundupyan Yulia , Bibov Mikhail
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
AI-Driven Energy Management Systems for Microgrids: Optimizing Renewable Energy Integration and Load Balancing
Authors: Bhardwaj Diwakar , M Shalini , Kanmani Jebaseeli S. , Jadhav Swati , Alabdeli Haider , Sutar Vasundhara , Senthil Kumar R.
Published: November 2024

The increasing adoption of microgrids, particularly with renewable energy sources, necessitates advanced energy management systems (EMS) that can efficiently handle dynamic power demands and supply fluctuations. This paper proposes an AI-driven EMS model specifically designed for optimizing energy distribution and load balancing within microgrids. The system leverages machine learning algorithms to predict energy demand and adapt the power allocation in real-time, ensuring efficient integration of renewable resources while maintaining grid stability. A simulation of the proposed system demonstrates significant improvements in energy efficiency and stability when compared to traditional EMS approaches. This research highlights the importance of intelligent systems in achieving sustainable and reliable microgrid operations.
An Efficient Asymmetric Inverter Design for PV Applications for Harmonics and Power Loss Mitigation
Authors: Lingaswamy Kandadi , Jebaseelan S.D. Sundarsingh
Published: November 2024

The electricity industry faces major problems due to the ubiquitous availability of fossil fuels and their rising consumption. One option is to use photovoltaic (PV) modules, which convert sunlight into electricity—at first, in the form of direct current (DC). But changing it to alternating current (AC) is essential for powering AC loads. Problems with electromagnetic interference (EMI) and harmonic distortion are common with traditional inverters. Because of this, multi-level inverters (MLIs) have been developed to reduce harmonic content. But current MLIs are often symmetrical and need an increasing number of switching devices as output levels rise, rendering them unsuitable for PV applications caused by environmental variations. In order to overcome these restrictions, this research suggests an asymmetric inverter that uses eight power switches to provide a fifteen-level output from asymmetrical direct current sources. Suggested topology's decreased amount of switches improves system efficiency by minimizing size and switching losses. To further enhance the inverter's output voltage profile and efficiency, Sinusoidal Pulse Width Modulation (SHEPWM) is used to efficiently reduce particular harmonics. In order to more effectively remove complex harmonics, the switching angles of the suggested MLI are adjusted using a Particle Swarm Optimization (PSO).
AI-Enhanced Battery Management Systems for Electric Vehicles: Advancing Safety, Performance, and Longevity
Authors: Farman Md. Khaja , Nikhila Jarabana , Sreeja A. Bhavya , Roopa B. Sai , Sahithi K. , Gireesh Kumar Devineni
Published: November 2024

Electric vehicles (EVs) are essential to lowering carbon emissions and solving global environmental issues. The battery powers EVs, making its management crucial to safety and performance. As a self-check system, a Battery Management System (BMS) ensures operating dependability and eliminates catastrophic failures. As batteries age, internal resistance increases and capacity decreases, hence a BMS monitors battery health and performance in real time. EV energy storage systems (ESSs) need a complex BMS algorithm to maintain efficiency. Using battery efficiency calculations that account for charging time, current, and capacity, this approach should reliably forecast the battery's SoC and SoH. As batteries age, internal resistance increases, reducing constant current (CC) charging time. By analyzing these changes, the SoH can be predicted more precisely. Conventional methods for estimating SoC and enhancing BMS performance, such as deep neural networks, are used to minimize error rates. However, as the battery ages, AI approaches have gained prominence for their ability to provide precise diagnostics, fault analysis, and thermal management. These AI-driven techniques significantly enhance safety and reliability during charging and discharging cycles. To further ensure safety, a fault diagnosis algorithm is integrated into the BMS. This algorithm proactively addresses potential issues, thus maintaining the efficiency and safety of the battery. The effectiveness of the proposed BMS algorithms are demonstrated through its successful application in an ESS, validating its capability to manage the battery’s state, enhance performance, and ensure operational sustainability in EVs.
Thermal Performance of Ternary Hybrid Nanofluid Flow over an Inclined Magnetic Surface with Solar Radiative Heat Flux
Authors: Akindele A. O. , Obalalu A. M. , Oladapo O. A. , Ohaegbue A. D. , Prasad Brijesh , Bajaj Mohit
Published: November 2024

This study examines the thermal mechanism of magneto-radiated hybrid nanofluids, composed of aluminium oxide (Al₂O₃), iron (II, III) oxide (Fe₃O₄), and copper II oxide (CuO) suspended in blood, with an emphasis on their application in biomedical engineering, The study makes use of a three-dimensional surface model to analyze the heat transfer characteristics and thermal behavior of ternary hybrid nanofluid under inclined magnetic fields and radiative heat conditions. The incorporation of Fe₃O₄ nanoparticles enhanced the thermal conductivity of the medium and responsiveness to magnetic fields, while Al₂O₃ and CuO nanoparticles improved overall stability and heat capacity. To evaluate the effectiveness of these ternary hybrid nanofluids for targeted thermal therapies and diagnostic procedures, the study uses homotopy analysis techniques to simulate the interactions between the nanoparticles and blood. The results show that these nanofluids have the potential to optimize thermal management in biomedical applications and provide knowledge about their benefits and performance.
Thermal Management Strategies in High-Power Energy Storage Device
Authors: Husain Saif O. , Shukla Aasheesh , Bharsakade R.S. , Prabhakar P.B. Edwin , Vijayaraghavan P. , Sherje Nitin , Tarigonda Hariprasad
Published: November 2024

High-power energy storage devices, such as lithium-ion batteries and supercapacitors, face significant thermal challenges during operation, which can affect their performance, safety, and longevity. Effective thermal management strategies are crucial for maintaining optimal temperature ranges, preventing thermal runaway, and ensuring efficient energy output. This paper explores various thermal management techniques, including active and passive cooling systems, phase change materials, and advanced heat sink designs, specifically tailored for high-power applications. A comprehensive analysis of these strategies is provided, along with insights into their implementation in real-world energy storage systems. Additionally, the paper discusses recent advancements in thermal management technologies and proposes potential improvements to enhance the safety and efficiency of high-power energy storage devices.
Development of an Energy-Efficient Digital Trainer for Logic Design Education Using ATmega328P Microcontroller
Authors: Owolabi A.O. , Oke A.O. , Obalalu A. M. , Khan Umair , Prasad Brijesh , Bajaj Mohit
Published: November 2024

In this paper, a digital trainer was designed and implemented. The purpose of a digital trainer is to teach students logic design skills in the digital electronics laboratory and provide them with hands-on experience in working with and modifying simple network digital circuits. The conventional digital electronics trainer is both costly to obtain and available in limited quantities in most electronics and computer engineering labs, which also leads to high maintenance expenses. Therefore, this project concentrates on developing a digital trainer that is both cost-effective and efficient. The digital trainer was designed with an ATmega328P Microcontroller, which helps monitor and control the functioning of the system features in accordance with a set of written program codes and whose operating voltage ranges from 3.3 to 5.5 volts. It was designed to involve a function generator and LEDs. The function generator requires 12V to generate different waveform outputs, while each LED requires a minimum voltage of 1.7V to glow. The user provides input through the logic switches to the logic gates, which are then read by the Microcontroller. When the input from the logic gate is detected, the ATmega328P Microcontroller sends output through to the LCD, displaying the features in operation with the LEDs and showing the result of the tested circuit.