bluuebunny/crossref_metadata_2025 huggingface dataset:
Preliminary Phytochemical Analysis and Invitro Antiplasmodial Activity of Terminalia mantaly Against Plasmodium falciparum
Authors: Usman Bello Muhammad , Attah Daniel Dan-Inna , Kanya Danladi Yusuf
Published: December 2022

Highlights:

Malaria is prevalent in many populations of communities despite preventive measures.
The experimental was screened for bioactive components which could be the reason for the antimalarial effect and the plant shows dose dependent antimalarial activity.

 
Abstract :
Malaria has been one of the world’s worst killer diseases throughout recorded human history. Despite attempts to eradicate the disease, it remains a global burden. This could be a result of parasite resistance to current therapy. However, this research aimed at evaluating the in vitro antimalarial activity of ethanolic extracts of Terminalia mantaly on Plasmodium falciparum. The plant extracts were prepared by cold maceration in 70% ethanol and air-dried by a rotary evaporator. The phytochemical analysis was carried out using standard procedures outlined in the Analytical methods of the Association of Official Analytical Chemists (AOAC, 1990) which indicates the presence of tannins, alkaloids, saponins, flavonoids, glycosides, phenol, steroids, and balsam. The in vitro antimalarial assay was carried out according to the method described by WHO (2001). All data were represented as Mean ± Standard deviation. Ethanolic extracts of the three parts of the plant were subjected to in vitro antimalarial activity at three concentrations (300 mg, 150 mg, and 75 mg) in four replicates with artemether (standard drug) as a positive control. Stem bark at 300 mg/kg completely cleared the parasites with a 0.00% parasitaemia rate and there was no significant difference when compared with positive control at p<0.005 value of 1.00. This study affirms the use of the plant for the treatment of malaria.
The Influence of Safety Communications and Safety Promotion Policies on Safety Performance among Nurses in The Emergency Department at a Tertiary Hospital in Surabaya, Indonesia
Authors: Berliana Ratih , Noeroel Widajati  , Nurhayati Saridewi  , Endang Dwiyanti
Published: December 2022

Highlights:

To reduce the occurrence of work-related accidents, the application of occupational safety and health principles in work activities is necessary.
This research analyzed the safety communications and safety promotion policies on the safety performance among nurses.
Safety communications have influence on safety performance, while safety promotion policies have no influence on safety performance.

 
Abstract:
The application of the occupational safety and health principles in work activities is expected to reduce the occurrence of work-related accidents. This research was conducted in the Emergency Department of a tertiary hospital of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, in 2019 and aimed to determine the influence of safety communications and safety promotion policies on the safety performance among nurses. This research was a quantitative research with a cross-sectional design study. The population in this study were 208 emergency room nurses at Dr. Soetomo General Academic Hospital with a total sample of 68 people using a simple random sampling technique. The results showed that the correlation between safety communications variable with safety performance had a p-value of 0.035 (<0.05) and the correlation between safety promotion policies variable with safety performance had a p-value of 0.319 (>0.05), indicating that there was    an influence of safety communications on safety performance, while there was no influence of safety promotion policies on safety performance among nurses in the Emergency Department of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
Healing of Radiation Dermatitis with Ozonated Aloe Vera Oil by Increasing PDGF and Epidermal Thickness in Sprague-Dawley Rats
Authors: Utami Widoasti Putri , Prajoko Yan Wisnu , Christina H.N. Prihharsanti  , Sadhana Udadi , Susilaningsih Neni , Restiwijaya Maryam , Nur Muhammad
Published: December 2022

Highlights:

This study demonstrated the effect of ozonated Aloe vera oil in the healing of radiation dermatitis wound.
Groups that received no treatment was compared with groups that received treatment using 2.5% hydrocortisone ointment and ozonated Aloe vera.
Ozonated Aloe vera oil improves the healing of radiation dermatitis wound by increasing PDGF expression and epidermal thickness.

 
Abstract :
The long-term use of corticosteroids as a standard treatment for skin disorders, such as radiation dermatitis, can cause many side effects. Alternatively, ozonated Aloe vera oil may replace corticosteroids due to its fewer side effects and benefits in wound healing process. Re-epithelialization and the formation of growth factors, such as platelet-derived growth factor (PDGF), play an important role in the healing of dermatitis wound. This study intended to demonstrate the effect of ozonated Aloe vera oil to improve the healing of radiation dermatitis wound by increasing PDGF expression and epidermal thickness. This study used a post-test only control group design. A sample of 36 Sprague-Dawley rats was divided into 6 groups (C1=without treatment, C2=2.5% hydrocortisone ointment, P1=pure Aloe vera (AV), P2=300 mg/mL ozonated Aloe vera (OAV), P3=600 mg/mL OAV, P4=1200 mg/mL OAV. The expression of PDGF was assessed using Allred scoring with immunohistochemical staining, whereas the epidermal thickness was assessed using hematoxylin and eosin (H&E) staining at 400x microscopic magnification. The PDGF expression and epidermal thickness between the control and the treatment groups showed significant differences using a Kruskal-Wallis test (P=0.001) and one-way ANOVA test (P<0.001). The groups that was given ozonated Aloe vera oil had higher average of PDGF expression and thicker epidermis than the other groups. The Spearman's correlation test showed a strong positive relationship (p<0.001 and r=0.709) between the two variables. In conclusion, ozonated Aloe vera oil improves healing of radiation dermatitis wound by increasing PDGF expression and epidermal thickness.
Sodium Hyaluronate Eye Drops for College Students with Computer Vision Syndrome in Indonesia
Authors: Zulkarnain Bambang Subakti , Loebis Rozalina , Aryani Toetik
Published: December 2022

Highlight:

Computer vision syndrome (CVS) that causes dry eyes becomes a health problem for college students.
Sodium hyaluronate eyedrops can be used as one of the CVS therapy strategies for students suffering from CVS.

 
Abstract:
The use of computers and mobile devices is increasing. Computers and mobile devices help our daily work or study. However, prolonged use of them may cause computer vision syndrome (CVS). Nowadays, CVS becomes a health problem for everyone working with computers or mobile devices including college students because it causes dry eyes. It may disrupt reading, doing professional work, or using a computer which is important for college students to complete academic tasks. Sodium hyaluronate can be used to overcome the dry eye problem due to CVS. To assess the effectiveness of sodium hyaluronate eyedrops on students suffering from CVS, pre- and post-administration of sodium hyaluronate was measured for two weeks. Inclusion criteria for this study were college students aged 20-35 years, using a computer for >2 hours a day, not using nonsteroidal anti-inflammatory drugs (NSAIDs), not consuming drugs, or having a disease that affects tear production and bearing no pregnancy. Parameters assessed include tear break-up time using the Tear Break-Up Time (TBUT) test, tear production using the Schirmer I test, the number of clinically subjective symptoms, and Ocular Surface Disease Index (OSDI) scores. Data were analyzed using student paired t-tests or Wilcoxon Rank Test. There were statistically significant differences before and after the TBUT (4.4 vs 6.7 seconds; p<0.0001); the Schirmer I Test (4 vs 6 mm; p<0.05), and the number of clinically subjective symptoms (3 vs 0 clinically subjective symptoms; p<0.0001). The OSDI scores did not show statistical differences before and after administration of sodium hyaluronate (27 vs 21; p>0.05), but there was a positive impact from moderate to mild dry eye. Sodium hyaluronate eyedrops can be used as one of the CVS therapy strategies for students suffering from CVS.
Gambaran Faktor Penyebab Ketidakpatuhan Ibu Hamil dalam Mengonsumsi Tablet Tambah Darah di Era Pandemi Covid-19
Authors: Atika Suri Windri Ayu , Puspitasari Dwi Retno , Pradipta Nadya Ratri , Ismawati Ismawati , Zainu Lisa Ariyanti , Darmawan Ni Made Eravikania Putri , Namira Desya Shafa , Jamil Fash Fachish Shofchal , Yudiaprijah Sahrati , Rahayu Elsa , Hermansyah Andi
Published: December 2022

Ibu hamil rentan mengalami anemia sehingga membawa dampak pada janin yaitu berat bayi lahir rendah (BBLR), kelahiran prematur, kecacatan, bahkan kematian bayi. Data Riskesdas tahun 2018 menunjukkan 48,9% ibu hamil mengalami anemia. Lebih dari 50% kasus anemia yang terbanyak di seluruh dunia disebabkan oleh kurangnya asupan zat gizi besi. Hal tersebut berkaitan dengan ketidakpatuhan ibu hamil dalam konsumsi tablet tambah darah. Kondisi ini diperparah dengan pandemi COVID-19 yang membatasi akses pelayanan kesehatan ibu dan anak (KIA). Penelitian ini bertujuan untuk menggambarkan faktor-faktor yang mempengaruhi ketidakpatuhan ibu hamil dalam mengonsumsi tablet tambah darah di era pandemi COVID-19. Jenis penelitian ini adalah penelitian cross sectional dengan instrumen berupa kuesioner. Responden penelitian ini adalah 104 orang ibu hamil. Hasil penelitian menunjukkan bahwa dari 104 responden terdapat 18 orang (17%) yang tidak patuh dalam mengkonsumsi tablet tambah darah. Menariknya, mayoritas responden yang tidak patuh memiliki karakteristik pendidikan sarjana, pekerjaan ibu rumah tangga, daerah tempat tinggal Pulau Jawa, dan menerima tablet tambah darah. Meskipun demikian, responden yang tidak patuh memiliki pengetahuan sedang, dukungan sekitar yang rendah, serta kondisi kehamilan yang tidak terdampak oleh pandemi.Kata Kunci: Anemia, ketidakpatuhan, tablet tambah darah, pandemi COVID-19
Efektivitas Penggunaan Layanan Telefarmasi di Era Pandemi COVID-19 dari Perspektif Masyarakat
Authors: Farid Abdul , Firdausy Adelia , Sulaiman Alifia , Simangunsong Dewi , Sulistyani Febi , Varianti Frizca , Ong Kevin , Kristiany Livia , Mustika Nancy , Febiani Natasha , Komalasari Salsabela , Salsabila Salsabila , Azzahra Sherin , Zulfah Yasmin , Aryani Toetik
Published: December 2022

Pandemi COVID-19 di Indonesia pertama kali diumumkan pada Maret 2020. Kasus COVID-19 yang terus meningkat mendorong pemerintah untuk menetapkan berbagai macam kebijakan untuk menekan angka positif COVID-19 seperti penerapan protokol kesehatan, physical distancing, dan Pemberlakuan Pembatasan Kegiatan Masyarakat (PPKM). Pandemi COVID-19 telah menimbulkan berbagai masalah kesehatan, salah satunya yaitu terhambatnya pelayanan kefarmasian. Oleh karena itu, penerapan telefarmasi di kalangan masyarakat dapat menjadi sebuah pelayanan alternatif demi mengurangi tendensi interaksi aktif secara langsung antara apoteker dengan pasien. Penelitian ini bertujuan untuk mengetahui efektivitas penggunaan layanan telefarmasi di era pandemi COVID-19 dari perspektif masyarakat. Penelitian ini merupakan penelitian Cross-Sectional dengan instrumen berupa kuesioner yang disebar secara online melalui google form. Pengambilan sampel dilakukan secara accidental sampling dengan kriteria inklusi masyarakat umum berusia 15-65 tahun yang berdomisili di Pulau Jawa.  Berdasarkan hasil survei  terhadap 243 responden, 90 responden (37,03%) pernah menggunakan telefarmasi dan dari 90 responden tersebut semuanya (100%) merasa terbantu dengan adanya pembelian obat secara online, 56 responden (62,2%) menyatakan pelaksanaan pemantauan terapi obat melalui telefarmasi berjalan dengan efektif, 58 responden  (64,4%) menyatakan pelaksanaan pemantauan efek samping obat berjalan dengan efektif, dan 72 responden (80%) dapat memahami Informasi obat yang diberikan. Hal ini menunjukkan bahwa  penggunaan telefarmasi di era pandemi COVID-19 efektif dari perspektif masyarakat. Namun, pemahaman dan minat masyarakat terkait telefarmasi masih kurang sehingga penggunaannya masih cukup rendah di masyarakat. Untuk itu perlu dilakukan promosi kesehatan terkait telefarmasi agar masyarakat lebih mengenal telefarmasi dan dapat memaksimalkan penggunaanya di era pandemi COVID-19.
Gambaran Pengetahuan dan Perilaku Masyarakat terkait Penggunaan serta Efek Samping dari Hand Sanitizer Beralkohol
Authors: Arganata Danicko Primada Wima , Amin Anisa Amelia , Alfaini Aufi Fillah , Pramesti Rohana Ayu , Oktaviani Siti Amalia , Christy Patricia Kinanty , Harahap Elizabteh Apriani , Wulandari Aan Rahmah , Kawaguchi Kurnia , Tahrina Adelia , Rif'at Nawal Ariqoh , Elkabidah Asga , Wijayanata Talitha Nabilla , Bobsaid Jihan , Darakita Cuttafia Della , Achmad Gusti Noorizka Veronika
Published: December 2022

Hand sanitizer beralkohol adalah salah satu produk hand hygiene yang banyak digunakan masyarakat terutama saat pandemi COVID-19. Tujuan pemakaiannya yaitu untuk menghilangkan kotoran serta mikroorganisme termasuk SARS CoV-2. Penggunaan hand sanitizer beralkohol harus diperhatikan agar memberikan efek yang maksimal serta tidak menimbulkan efek samping yang signifikan. Penelitian ini bertujuan untuk mengetahui pengetahuan dan perilaku masyarakat terkait penggunaan dan efek samping dari hand sanitizer beralkohol. Penelitian ini merupakan penelitian cross sectional dengan analisis data deskriptif-analitik kuantitatif. Responden dalam penelitian ini adalah masyarakat berumur 18-60 tahun yang sedang atau pernah menggunakan hand sanitizer. Pengambilan data dilakukan dengan metode survei. Teknik sampling yang digunakan adalah metode convenience sampling. Sebanyak 387 responden berpartisipasi pada penelitian ini. Tingkat pendidikan responden yang paling banyak adalah SMA dengan persentase 78% (n=302). Hasil penelitian menunjukan mayoritas pengetahuan masyarakat terkait hand hygiene, efektivitas maupun efek samping kurang baik. Dari hasil uji beda menggunakan Fisher’s exact antara tingkat pendidikan dan pengetahuan dalam penelitian ini tidak signifikan (p=0,203). Hasil terkait perilaku masyarakat dalam menggunakan hand sanitizer menunjukkan bahwa 77,7% responden paling sering menggunakan hand sanitizer saat berada di tempat umum dan 36,6% responden menggunakan hand sanitizer sebanyak dua sampai tiga kali sehari. Sebanyak 69 responden menyatakan pernah mengalami efek samping. Efek samping terbanyak adalah kulit kering yang dialami oleh 56 responden, yang diakibatkan oleh terlalu sering menggunakan hand sanitizer. Pengetahuan dan perilaku masyarakat terkait penggunaan hand sanitizer masih perlu ditingkatkan khususnya mengenai kewaspadaan kandungan alkohol dalam hand sanitizer.
EXPLANATION STUDY OF AGRO-INDUSTRIAL FIRM FINANCIAL PERFORMANCE BASED ON CAPITAL STRUCTURE AND FIRM STRATEGY IN THE COVID-19 PANDEMIC
Authors: Budi Sulistiyo Agung , Bunga Maharani  , Bayu Aprillianto  , Novi Wulandari Widiyanti  , Muhammad Miqdad
Published: December 2022

The purpose of this study was to examine the effect of corporate strategy on financial performance with capitalstructure as an intervening variable. The advantage of this research lies in taking the object of the company inthe agroindustry sector in the Covid-19 pandemic situation which has not been the concern of researchers. Thepopulation is all agroindustry companies, listed in Indonesian Stock Exchange. Data collection technique usingpurposive sampling method and a total of 52 sample data were obtained with a time span of 2020-2021 whichwere processed using the multiple regression method. The results show that there is an effect of corporatestrategy on capital structure, as well as capital structure that affects financial performance. However, theopposite result is shown by the non-influence of corporate strategy variables on financial performance. Thus,the mediating role of capital structure in the relationship between corporate strategy and financial performancehas been clearly proven. The results of this study are able to provide future research recommendations in theform of using variations of company strategies that can have different implications, especially for companies inthe agroindustry sector during the covid-19 pandemic. In addition, this study also recommends companies tomanage their capital structure optimally to generate value to financial performance. This research will alsocontribute on the fast growth of literature related to corporate strategy, capital structure, and financialperformance as well as the development of agency theory, signal theory and pecking order theory.
IMPACT OF THE COVID-19 PANDEMIC ON THE OPERATIONS OF THE BREAST IMAGING UNIT OF A NON-PANDEMIC HOSPITAL IN TURKEY
Authors: COŞKUN BİLGE Almıla , MUSAPAŞAOĞLU AYDIN Hale , ESEN BOSTANCI Işıl
Published: December 2022

AIM: We aimed to evaluate changes in patient numbers, procedures performed, and the result of imaging procedures in the breast imaging unit of a non-pandemic hospital in Turkey during the COVID-19 pandemic.

MATERIAL AND METHOD: The study retrospectively evaluated 2010 and 740 patients who presented to our unit in the pandemic and non-pandemic periods, respectively. Patient sex and age, neoadjuvant chemotherapy story, imaging modalities used, final BI-RADS classification, and biopsy and/or wire localization procedures were compared between the periods.

RESULTS: There were significant decreases in the number of patients who presented to our unit and the numbers of mammography, ultrasound, MRI, biopsy, and wire localization procedures performed during the pandemic period (p
Política antidopaje, prensa y franquismo: el caso de la Vuelta a Inglaterra de 1965 = Anti-doping policy, press and Francoism: the case of the Tour of England of 1965
Authors: Font Noguerol Dani
Published: December 2022

ResumenEn 1965, los ciclistas Luis Pedro Santamarina, Salvador Canet y Jesús Usamentiaga fueron descalificados de la Vuelta a Inglaterra por dar positivo en anfetamina en el control antidopaje. Este artículo pretende analizar la respuesta de los periodistas de ABC y Mundo Deportivo (MD) ante el primer caso de dopaje que implicó a deportistas españoles. Previamente, esos periódicos ya habían informado de casos de dopaje en el ciclismo. La diferencia era que, por vez primera, los acusados eran deportistas de la misma nacionalidad que los periodistas.El caso se enmarca en los inicios de la política antidopaje, poco después de la celebración del primer congreso europeo sobre dopaje celebrado en el Consejo de Europa (CE). Los médicos asistentes al CE, incluidos médicos españoles como Jesús Fernández Cabeza,  expresaron su deseo de que los periódicos hiciesen llegar a su audiencia la peligrosidad del dopaje. En general, los periódicos españoles contribuyeron a difundir el discurso científico hegemónico, aunque como analizaremos en esta investigación, la defensa del héroe nacional pasó por encima de los intereses de los portavoces de la política antidopaje. AbstractIn 1965, the cyclists Luis Pedro Santamarina, Salvador Canet and Jesús Usamentiaga were disqualified from the Tour of Britain after a positive test on amphetamine in anti-doping control. This article aims to analyze the response of theABCandMundo Deportivo(MD) journalists to the first case of doping thataffected Spanish athletes. Previously, these newspapers had already reported doping cases in cycling. The difference was that, for thefirst time, the protagonists were athletes of the same nationality as the journalists.The case took place at the beginning of anti-doping policy, shortly after thefirst European Congress on doping held in the Council of Europe (CE). Doctors attending the CE, including Spanish physicians like Jesús Fernández Cabeza, expressed a desire for journalists to bring to their audience the danger ofdoping. In general, Spanish newspapers contributed to the spread of the hegemonic scientificdiscourse based on evidence, although, as we will analyze in this research, the defense of the national hero passed over the interests of the spokesmen of anti-doping policy.
Effect of SO2, glutathione and gallotannins on the shelf-life of a Cortese white wine bottled with different oxygen intakes
Authors: Motta Silvia , Tirelli Antonio , Cravero Maria Carla , Guaita Massimo , Bosso Antonella
Published: December 2022

The work aimed to study the effect of adding reduced glutathione (GSH) and/or gallotannins at bottling on the shelf-life of a Cortese white wine to limit the use of SO2.The experimental trial was carried out following a full factorial plan consisting of 8 experimental trials that differed for the content of free SO2 (2 levels: 20 and 40 mg/L), the absence/presence of gallotannins (0 and 40 mg/L) and GSH (0 and 20 mg/L). The wines of the eight trials were oxygenated respectively at 5.5 ppm and 4.0 ppm of O2. The wines oxygenated at 5.5 ppm were bottled in 135 mL bottles and monitored during 12 months of storage (colour, polyphenolic composition, GSH, free and total SO2); the wines oxygenated at 4.0 ppm of O2 were bottled in 750 mL bottles, then analysed and tasted after 15 months. The oxygen consumption rate (OCR) was measured with a luminescence-based technology. The OCR followed a first-order kinetic in all the wines, and a significant OCR acceleration was observed when increasing the concentration of free SO2. A significant increase in OCR was also observed in the samples with GSH, albeit to a lesser extent than with SO2, while the addition of gallotannins caused a decrease in the OCR. It is possible that similar mechanisms are at the basis of the acceleration of OCR observed with GSH and SO2. However, unlike SO2, GSH showed poor antioxidant efficacy in the protection of both the colour and the aromatic component, probably also due to its lower molar concentration.The presence of GSH limited the oxidative losses of SO2, mostly in wines with higher SO2 levels. However, the effect of GSH decreased over time, since after 8 months, GSH was only present in traces. The resistance to oxidative browning of wines during bottle storage depends on the concentration of free SO2 present in the medium (> 10 mg/L), therefore, higher GSH intakes, such as to ensure sufficient preservation of the free SO2 content during storage, will have to be tested to evaluate the possibility of prolonging the shelf-life of wines.
Crosstalk of Airway Smooth Muscle and Epithelial Cells in Chronic Lung Diseases
Authors: Abohalaka Reshed
Published: December 2022

Chronic pulmonary diseases such as asthma, COPD, and Idiopathic pulmonary fibrosis are significant causes of mortality and morbidity worldwide. Currently, there is no radical treatment for many chronic pulmonary diseases, and the treatment options focus on relieving the symptoms and improving lung function. Therefore, efficient therapeutic agents are highly needed. Bronchial epithelial cells and airway smooth muscle cells and their crosstalk play a significant role in the pathogenesis of these diseases. Thus, targeting the interactions of these two cell types could open the door to a new generation of effective therapeutic options. However, the studies on how these two cell types interact and how their crosstalk adds up to respiratory diseases are not well established. With the rise of modern research tools and technology, such as lab-on-chip, organoids, co-culture techniques, and advanced immunofluorescence imaging, a substantial degree of evidence about these cell interactions emerged. Hence, this contribution aims to review the growing evidence of bronchial epithelial cells and airway smooth muscle cells crosstalk under normal and pathophysiological conditions. The review first deliberates the effects of both healthy and stressed epithelial cells on airway smooth muscle cells, taking into account three themes; contraction, migration, and proliferation. Then, it discusses the impact of airway smooth muscle cells on the epithelium in inflammatory settings. Later, it examines the role of airway smooth muscle cells in the early development of bronchial epithelial cells and their recovery after injury.
Open-source-based Approach to Delineate the Shoreline from Space: A Case Study in Failaka Island, the State of Kuwait
Authors: Albanai Jasem
Published: December 2022

Researchers need to delineate the shoreline for different applications with no access to costly resources such as topographic maps and high-resolution satellite images. With the increase of open source data, this study aims to present a methodology to use open source data in the best possible way to map the shoreline. Several methods have been tested using open source remote sensing data (Landsat and Aster), such as supervised classification, unsupervised classification, manual mapping, and by applying some spectral indices, among others. The accuracy of the extracted shoreline data was verified using high-resolution open database images (such as Google Earth basemap). The results showed that the manually mapped shoreline through applying spectral index (green- near infrared/green+ near infrared) is the most accurate, although it remains important to modify it using high-resolution images of open databases. Open-source data showed acceptable accuracy in mapping the shoreline.
Mathematical model of the passage of audio signals in network-based audio analytics systems
Authors: Poroshenko Anton
Published: December 2022

Relevance. Nowadays, more and more audio and video analytics systems work together. But in many cases, it is necessary to quickly transfer the audio stream. Therefore, the task of reducing delays in transmission of audio streams in network-based audio analytics systems becomes relevant. The object of research is the process of audio signal transmission. The subject of research is mathematical models of audio and video streams in network systems. The purpose of this paper is to develop a mathematical model for the passage of audio signals in network-based audio analytics systems. Research results. The statement of the problem of optimizing the network of connecting lines according to the criterion of minimum capital costs is proposed. Optimization equations for a unidirectional three-node basic structure are compiled based on the problem of minimizing capital costs. Optimization equations are obtained for a bidirectional three-node basic structure. Obtained optimization equations are generalized to any structure of a network of connecting lines. The direction of further research is the development of an approximate method for quickly solving optimization equations for a network of connecting lines and assessing the adequacy of the developed model.
STRATEGI PENANGGULANGAN BANJIR BERDASARKAN PRESEPSI MASYARAKAT DI KAWASAN PT JIEP (JAKARTA INDUSTRIAL ESTATE PULOGADUNG) DKI JAKARTA
Authors: Doan Otanti Agustina Doan Otanti Agustina , Abbas Hafid , Sucahyanto Sucahyanto
Published: December 2022

Abstrak

Penelitian ini berjudul “STRATEGI PENANGGULANGAN BANJIR BERDASARKAN PRESEPSI MASYARAKAT DI KAWASAN PT JIEP (JAKARTA INDUSTRIAL ESTATE PULOGADUNG)DKI JAKARTA”.dalam hal ini bertujuan untuk 1) Mengetahui Strategi Penanggulangan sebelum Banjir di Kawasan PT JIEP (Jakarta Industrial Estate Pulogadung). 2) Mengetahui Strategi Penanggulangan saat Banjir di Kawasan PT JIEP (Jakarta Industrial Estate Pulogadung). 3) Mengetahui Strategi Penanggulangan sesudah Banjir di Kawasan PT JIEP (Jakarta Industrial Estate Pulogadung).   

 

Penelitian menggunakan metode: Kegiatan survei dan kajian literatur dilaksanakan dengan mengumpulkan data dan informasi tentang banjir, hasil kajian, dan Selain itu, dilakukan wawancara singkat dan terarah dengan responden dari profesional PT JIEP (intermediaries) dan masyarakat (beneficiaries).

 

Hasil dalam penelitian saya, menunjukan bahwa strategi penanggulangan banjir berdasarkan persepsi masyarakat didaerah Kawasan PT Jakarta Insustrial Estate Pulogadung (JIEP) di Kecamatan Cakung kota administrasi Jakarta Timur berada pada kategori “sedang yang mana persiapan dan bantuan di dan normalisasi di bantu oleh pemerintah setempat.

Kata Kunci : Strategi penaggulangan, Banjir, Masyarakat kawasan PT JIEP.
Pengembangan kegiatan motorik halus anak usia 4-6 tahun di rumah pada masa pandemi covid 19 di tkk kspa dki jakarta
Authors: Indah Pujiastuti Sri , Anggiani Meri
Published: December 2022

Tujuan pengabdian masyarakat ini adalah untuk membantu orangtua dalam membelajarkan anak-anak di rumah khususnya pengembangan kegiatan motorik halus anak usia 4-6 tahun. Pengembangan kegiatan motorik halus sangat penting karena anak-anak harus mencapai tugas-tugas perkembangan motorik pada usia tersebut seperti menggunting, memegang pensil, menggambar, menulis nama dan angka, berpakaian, menyikat gigi dan menyisir rambut. Metode pengabdian yang digunakan adalah penyuluhan orangtua dan pembelajaran online seminggu sekali selama 3,5 jam dengan sample 3 lokasi TK di Kebon Baru, Rawamangun dan Kampung Bandan sebanyak 56 anak selama masa pandemic Agustus sd Desember 2020. Hasil pengabdian adalah orangtua mampu melatih motorik halus anak usia TK dengan berbagai kegiatan seperti menggambar, memegang pensil, menulis nama dan angka, berpakaian, menyikat gigi dan menyisir rambut. Selain itu, kemampuan motorik halus anak meningkat. Kesimpulan pengabdian adalah kegiatan penyuluhan dan pengembangan kegiatan ini sangat efektif dan efisien dalam meningkatkan keterampilan orangtua dan anak dalam pengembangan motorik halus anak.
High temperature sensitivity of monoterpene emissions from global vegetation
Authors: Bourtsoukidis Efstratios , Pozzer Andrea , Williams Jonathan , Makowski David , Penuelas Josep , Matthaios Vaseilios , Lazoglou Georgia , Yañez-Serrano Ana , Ciais Philippe , Lelieveld Jos , Vrekoussis Mihalis , Daskalakis Nikolaos , Sciare Jean
Published: December 2022

Terrestrial vegetation emits vast amounts of monoterpenes into the atmosphere, influencing ecological interactions and atmospheric chemistry. Global emissions, mostly driven by responses to abiotic stress, are simulated as a function of temperature with a fixed exponential relationship (β coefficient) across forest ecosystems and environmental conditions. We applied meta-analysis algorithms on all published monoterpene emission data and show that this relationship is more intricate and sensitive than previously thought. We find that co-occurring environmental stresses amplify the temperature sensitivity of the emissions that is primarily related to the specific plant functional type (PFT). On average, warmer ecosystems appear more sensitive, indicating the adjustment of plants in response to thermal stress. Implementing a PFT-dependent β in a biogenic emission model, coupled with a chemistry – climate model, demonstrated that atmospheric processes are exceptionally dependent on monoterpene emissions which are subject to amplified variations under rising temperatures.
Investigation of inhibiting factors of dysphagia rehabilitation in cardiovascular patients treated with invasive and non-invasive mechanical ventilation
Authors: Nakamura Tomoyuki , Kurosaki Shuhei , Baba Mikoto , Mizushima Takashi
Published: December 2022

Objectives
To clarify the factors inhibiting dysphagia rehabilitation in cardiovascular patients treated with invasive and non-invasive mechanical ventilation (MV).
Methods
The subjects were patients with dysphagia and cardiovascular disease treated with MV who were admitted to our hospital between April 2019-December 2021. Age, sex, walking ability, Geriatric Nutritional Risk Index (GNRI), primary heart disease, Charlson Comorbidity Index (CCI), invasive or non-invasive MV, Sequential Organ Failure Assessment (SOFA) at the start of MV, duration of MV, days from the withdrawal of MV to the start of rehabilitation, Functional Oral Intake Scale (FOIS) at the start of rehabilitation and discharge, length of hospital stay, pneumonia after the start of rehabilitation, and death during hospitalization were retrospectively surveyed.
Results
Ninety-six of the 105 patients survived, and 37 patients recovered from dysphagia. Twenty-two patients needed alternative nutrition at the start of rehabilitation, which was significantly associated with the duration of MV, length of hospital stay, and pneumonia after the start of rehabilitation. Death during hospitalization was significantly associated with lower GNRI scores, a history of chronic pulmonary disease, lower FOIS scores at the start of rehabilitation, and pneumonia developed during hospitalization. Dysphagia at discharge was significantly associated with older age, walking disability, lower GNRI scores, congestive heart failure, higher CCI scores, non-invasive MV, and higher SOFA scores.
Conclusions
The factors inhibiting dysphagia rehabilitation in cardiovascular patients treated with MV differed between the initial evaluation and outcomes and between vital and functional outcomes. Nutritional risk is a common risk factor for vital and functional outcomes.
Evaluation of Famacha© Method as a Selective Treatment Criteria to Aid to Conserve the Canindé Goats Breed
Authors: Goes Sarah Diogenes Mendonca de Mattos Brito , Ferreira Josiel , Silveira Robson Mateus Freitas , Bezerra Ana Carla Diógenes Suassuna , Façanha Débora Andréa Evangelista
Published: December 2022

This study evalueted the efficiency of the application of the Famacha© (F ©) system in goats of the Canindé breed. 161 goats were selected, which were examined and classified into 5 categories, F©1 to F©5. Blood samples were collected for complete blood count to get a health profile and hematocrit count (HTC), egg count per gram of feces (ECC) and stool culture to confirm the presence of H. contortus, in two periods of the year, dry and rainy. There were no significant differences between the HTC and F© data between the analyzed periods, and no animal was classified as truly anemic. Therefore, the study concluded that there is a contradictory relationship between the classification of anemia using the F© system, ECC and HTC values related to H. contortus infection, not suggesting the use of the F© method for Canindé goats and still proposing the elaboration of new HTC tracks associated with F© scores.
Wage returns to English language and technical skills in India: An inter-occupational disparity
Authors: P Azad , Refeque Muhammed
Published: December 2022

This study examines the wage returns to education, English language skills and the computer skills across various occupations in India, and analyses how the returns vary across gender, rural urban sector, age group, caste, and wage structure within each occupation. Respondents are classified into four important occupational groups such as professionals and executives, farmers and related workers, production related workers, and service-related workers. Using selectivity correction methods, the study finds that the returns to linguistic ability, computer skills and education are high for the professionals and executives and service-related workers. The study also found significant inter-occupational variation in returns to linguistic and computer skills by gender, rural/urban area, caste and across wage structure. The findings of the study also proves that the linguistic and technical skills complement the education and experience across different job categories in India. Higher returns to English skills accrue more to the educated workers across the occupations and such impacts are more in the case of professional and service sectors. The study emphasises on the importance of extending education and imparting skills to people in order to reduce the labour market discriminations as the education and skills have a profound impact on enhancing the wage earnings irrespective of the socio-demographic backgrounds of the people. The study also shows that, pursuing education and acquiring skills are real investments as they ensure better returns regardless of the job categories.
JEL Classification I 24 · I 26 · J 01 · J 24 · J 31 · J 46
Aβ43 levels determine the onset of pathological amyloid deposition
Authors: Tambini Marc D. , Yin Tao , Yesiltepe Metin , Breuillaud Lionel , Zehntner Simone P. , D'Adamio Luciano
Published: December 2022

Background
While most Alzheimer’s disease cases are sporadic with late onset (LOAD), ~ 2% of cases are inherited, have an early onset, and are caused by mutations in Presenilins (PSEN1/2) or Amyloid-β Precursor Protein (APP) genes (familial AD, FAD). PSEN1/2 are the catalytic component of γ-secretase, a protease that generates Aβ peptides of different length from APP. Aβ peptides are the major components of amyloid plaques, a pathological lesion that characterizes AD. Analysis of mechanisms by which PSEN1/2 and APP mutations affect Aβ peptide compositions lead to the implication of the absolute or relative increase in Aβ42 levels in amyloid-β plaques formation and AD pathogenesis. The age at onset of FAD depends on the mutation and can differ by decades, suggesting a link between age at onset of dementia and the effects of distinct FAD mutations on Aβ species profiles. It is reasonable to presume that Aβ peptide compositions that initiate amyloid pathology and disease in FAD patients can also inform about disease mechanisms driving the more common LOAD cases.
Methods
Here, to elucidate the formation of pathogenic Aβ cocktails leading to amyloid pathology, we utilized rat knock-in models of FAD carrying the Swedish APP (Apps allele) and the PSEN1 L435F (Psen1LF allele) mutations. To accommodate the possibility of differences in pathogenicity of rodent and human Aβ, these rat models are genetically engineered to express human Aβ species as both the Swedish mutant allele and the wild-type rat allele (called Apph) have been humanized in the Aβ-coding region.
Results
Analysis of the 8 possible FAD mutant permutations demonstrates correlations between mutation-driven alterations in Aβ profiles and amyloid pathology, and indicates that the CNS levels of Aβ43, rather than absolute or relative increases in Aβ42, determine the onset of pathological amyloid deposition.
Conclusions
This study corroborates the critical pathological importance of alterations in the Aβ peptides composition, helps clarifying the molecular determinants initiating amyloid pathology, and supports therapeutic interventions targeting Aβ43 to prevent, delay, or revert AD.
Models of Dental Care for People Experiencing Homelessness in the United Kingdom - A Systematic Review of the Literature.
Authors: Bradley Natalie , Heidari Ellie , Andreasson Sam , Newton Jonathon
Published: December 2022

Background
People who experience homelessness have poor oral health and face significant barriers to accessing care. Recommendations have been outlined for health services to address their needs - termed Inclusion Health.
The Smile4Life report recommended dentistry for this group should have three ‘tiers’ of service: emergencies, ad hoc treatments and routine care. In primary care, other medical services have developed into two models of care. They are either mainstream practices that offer care with enhanced services for people who experience homelessness, or an integrated model where specialist services bridge the gap between primary and secondary care.
There is little understanding of how Inclusion Oral Health recommendations have been implemented across dental settings; particularly across different geographies and within the different stages of homelessness.
Aims
Describe and compare dental services that exist for people who experience homelessness in the UK.
Methods
Two medline searches were performed in October 2020 to assess the models of dental care for people who experience homelessness in the UK, including rough sleepers, the hidden homeless, travellers, sex workers and vulnerable migrants.
Results
The search resulted in nine dental services which were dedicated to treating people who experience homelessness. The majority did not explore the specific definitions of homelessness and only one service cared for gypsies and travellers.
There were a mixture of models of care, including using blended approaches such as different sites and appointment types to flex to the needs of their population.
Conclusion
Many services that are dedicated to treat people who experience homelessness in the UK are based in the Community Dental Services which allows for flexible models of care due to sporadic patient attendance, high treatment requirements and complex needs.
More research is required to determine how other settings can accommodate these patients as well as understanding how more rural populations access dental care.
Generating Direct Current Electricity from Dripping or Flowing Ionic Water
Authors: Luo Jikui , Kuang Haoze , Huang Shuyi , Zhang Kaihang , Cai Xinyu , Wang Haobin , Zhang Chi , Chen Jinkai , Li Yubo , Wang Xiaozhi , Jin Hao , Dong Shurong , Yang Zongyin , Hasan Tawfique , Wang Zhong Lin
Published: December 2022

Generation of electricity from flowing salt water is extremely attractive as the resources are abundant and green. We propose a generator to harvest DC electricity from flowing ionic solution. The device consists of a substrate with fixed surface charges, a top electrode and a bottom electrode separated with a distance. The electrostatic field originated from the surface charges separates charges of opposite polarities in the solution, while the flow directs the charges to different electrodes in a closed circuit. By utilizing ultrahigh charge density of ferroelectric substrate and ionic solution, the device produces pulsed DC output for droplets and constant current for continuous flow. The output could be greatly enhanced by using substrates with high surface charge densities and high ion concentration solutions. It could also be scaled up by connecting the devices in series or parallel. This work provides a new strategy to harvest low hydrodynamic energy from sea.
Natural Language Processing based Obtaining Information in Pathology Report of Breast Cancer: Single-Institution Study
Authors: Park Phillip , Choi Yeonho , Han Na Young , Hwang Juyeon , Chae Gyeong Min , Kim Minkyung , Chae Heejung , Yoo Chong Woo , Choi Kui Son , Kim Hyun-Jin
Published: December 2022

Background: In 2018, breast cancer was the second most common cancer worldwide. Pathology reports provide important information for optimal treatment decision making.
Objective: To elucidate the deployment of deep learning data extraction methods for pathology reports in a single institute, we investigated the performance of methods between regular expression and natural language processing (NLP) in terms of accuracy.
Methods: This was compared to the bidirectional encoder representations from transformers (BERT) model using specific vocabulary such as BERT-basic, BioBERT, and ClinicalBERT. A total of 1,215 pathology reports were used to build annotated data to develop an extraction algorithm for pathology reports. K-fold cross-validation was used to verify the performance of BioBERT and ClinicalBERT, pre-trained in the BERT model.
Results: Among them, BioBERT emerged as a highly accurate (0.99901) data parsing model based on by k-fold validation. The parsing method using the NLP model could obtain data with higher overall accuracy than the existing method using regular expressions.
Conclusions: Our results showed that BioBERT has high accuracy in pathology reports, and that the NLP model can obtain data with a higher overall accuracy than regular expressions. Taken together, our findings suggest that the process of obtaining information from pathology reports should include NLP using BioBERT.
Marker-free quantification of progenitor population reveals incipient cell fate commitments
Authors: He Xionglei , Deng Shanjun , Gong Han , Zhang Di , Liu Li
Published: December 2022

Quantifying the number of progenitor cells that founder an organ, tissue or cell population is of fundamental value for understanding the development and homeostasis of a multicellular organism. Previous efforts rely on marker genes that are specifically expressed in progenitors. The strategy is, however, hindered often by the lack of ideal markers. By exploring the cell phylogenetic tree that records the cell division history during development, we here describe a general statistical method able to quantify the progenitors of any tissues or cell populations defined in an organism without progenitor-specific markers. The method, termed as targeting coalescent analysis (TCA), computes for all cells of a tissue the average coalescent rate at the monophyletic clades of the target tissue, the inverse of which then measures the progenitor number of the tissue. Both theoretical deduction and computer simulations supported the underlying logics of TCA, which was then validated by empirical data of nematodes, fruit fly and mouse, all with required cell phylogenetic trees. We further showed that TCA can be used to identify lineage-specific gene expression upregulations during embryogenesis, revealing incipient cell fate commitments in mouse embryos.
The Curious Case of the Structural Phase Transition in SnSe: Insights from Neutron Total Scattering
Authors: Jiang Bo , Neu Jennifer , Olds Daniel , Kimber Simon , Page Katharine , Siegrist Theo
Published: December 2022

At elevated temperatures SnSe is reported to undergo a structural transition from the low symmetry orthorhombic GeS-type to a higher symmetry orthorhombic TlI-type. Although increasing symmetry should likewise increase lattice thermal conductivity, many experiments on single crystals and polycrystalline materials indicate that this is not the case 1,2. Here we present temperature dependent analysis of time-of-flight (TOF) neutron total scattering data in combination with theoretical modeling to probe the local to long-range evolution of the structure. We report that while SnSe is well characterized on average within the high symmetry space group above the transition, over length scales of a few unit cells SnSe remains better characterized in the low symmetry GeS-type space group. Our finding from robust modeling provides further insight into the curious case of a dynamic order-disorder phase transition in SnSe, a model consistent with the soft-phonon picture of the high thermoelectric power above the phase transition.
Assessment of Genomic Prediction Strategies after Animal Genome-Wide Association Study
Authors: Wang Jiabo , Peng Wei , Chen Li , Kangzhu Yixi , Zhong Jincheng
Published: December 2022

Background
The detection of candidate variants with interesting traits is a major goal of a genome-wide association study (GWAS). GWAS-associated markers are considered candidate functional loci regarding animal and plant breeding and can serve to predict and treat human genetic diseases. Significant selected markers are functionally validated via molecular biology experiments or statistically validated by genomic prediction (GP) in an individual population. GWAS in a whole population used for GP causes an overprediction regarding accuracy. However, whether this overprediction exists in any traits with different genetic architectures remains unknown, while the extent of the difference between overprediction and actual prediction is also undetermined. The lack of whole key genetic information and linear dependence ubiquity can make perfect prediction of traits of interest impossible. A stable and adaptable prediction method for multiple genetic architectures is thus essential.
Results
We used a public dataset to present the accuracy bias in a cross-validation population with different genetic architectures and developed an approach termed “marker-assisted best linear unbiased prediction (MABLUP),” with removed linear dependence to improve the prediction accuracy for complex traits with genetic architectures. The MABLUP showed better prediction accuracy than other methods for traits under the control of few quantitative trait nucleotides (QTNs) and similar prediction accuracy to the best-known methods for traits under many QTNs.
Conclusions
The reasonable design of GP in the cross-validation after animal GWAS can be used to present actual potential breeding ability of detected significant markers. The MABLUP is a more stable and accurate GP method for more complex genetic traits.