bluuebunny/crossref_metadata_2025 huggingface dataset:
Transport Efficiency of a Homogeneous Gaseous Substance in the Presence of Positive and Negative Gaseous Sources of Mass and Momentum
Authors: Ptaszyński Bogusław , Kuczera Zbigniew , Życzkowski Piotr , Łuczak Rafał
Published: September 2022

In this article, a theoretical mathematical model of gas flow through a duct in the case of local mass and momentum sources and sinks is presented. The continuity equation and motion equation with one-dimensional, density-stable gas flows were used to create this model. The size of sources and sinks and their locations have an effect on the size of gas stream flows in the duct, gas energy losses, and the parameters of the mechanical source energy that is causing the flow. In the traditional approach to describing the gas flow in the duct, the concept of resistivity and the equivalent resistance of the conduit is used. In the case of flow in the duct with local mass and momentum sources and sinks, the transport resistance depends on a bigger number of parameters than the concept of specific resistance usage. The location and size of the source flux or mass and momentum sinks and the fan work (suction, blowing) were taken into account in the presented model. The model gives the opportunity to determine the mechanical energy losses and efficiency of gas transport in the duct.
Effects of One-Shot Hyaluronic Acid Injection in Lifelong Premature Ejaculation: A Pilot Study
Authors: Perri Anna , Lofaro Danilo , Iuliano Stefano , Bossio Sabrina , Rago Vittoria , Damiano Rocco , Di Luigi Luigi , La Vignera Sandro , Mondaini Nicola , Aversa Antonio
Published: September 2022

The therapeutic management of premature lifelong ejaculation (PE) ranges from behavioral therapy to pharmacological and surgical treatments. Hyaluronic Acid (HA) injection into the glans penis is a non-surgical procedure, intended to reduce glans hypersensitivity, improving the intravaginal ejaculation latency time (IELT). HA injection can be performed through different techniques that, although safe and effective, rarely can cause local complications. In this pilot uncontrolled study, we tested the effectiveness of a new technique based on a single HA injection into the frenulum of the glans, to improve IELT in a sample of patients affected by PE. We observed a significant increase of the IELT after one (median 73.3, IQR 66.2–79.9 s) and two months (66.2, 63.1–73.9) that gradually decreased at three months, remaining still significantly higher than at baseline (34.8, 30.9–37.4). PEDT and IIEF questionnaires significantly improved compared to baseline in the first two months of follow-up (p < 0.001). In conclusion, the preliminary results emerging from this pilot uncontrolled study, highlight the effectiveness of this one-shot HA injection approach, although a larger sample and longer follow-up time are needed to standardize the procedure.
A Key Study on Pollen-Specific SFB Genotype and Identification of Novel SFB Alleles from 48 Accessions in Japanese Apricot (Prunus mume Sieb. et Zucc.)
Authors: Coulibaly Daouda , Hu Guofeng , Ni Zhaojun , Ouma Kenneth Omondi , Huang Xiao , Iqbal Shahid , Ma Chengdong , Shi Ting , Hayat Faisal , Karikari Benjamin , Gao Zhihong
Published: September 2022

Self-incompatibility (SI) is a common strategy to avoid inbreeding and, consequently, keep genetic diversity within a species. In its mechanism, pollen rejection happens in the style when the single multiallelic locus (SFB in prunus species) of the haploid pollen matches one of the S-alleles existing in the diploid pistil. The SFB gene for the pollen S gene has been identified in many Prunus species. However, Japanese apricot is a species with a typical gametophytic self-incompatibility (GSI), and its SFB alleles available are limited, although they are required for studying GSI. Therefore, we used an AS-PCR amplification method, sequencing, and the pair primers SFB-C1F and Pm-Vb designed based on the conserved region of the Prunus SFB gene to identify SFB genotypes of 48 Japanese apricot (P. mume) accessions. Eleven novel SFB alleles were isolated from these accessions and shared typical structural features with SFB alleles from other Prunus species. These novel SFB alleles were uniquely expressed in pollen. Hence, we concluded that these 11 PmSFB were pollen S determinants of P. mume. This current study offers the novel SFB genes of the P. mume S locus, which could be a useful potential resource for studies on pollen SI mechanisms.
Estimating Carbon Stocks and Biomass Expansion Factors of Urban Greening Trees Using Terrestrial Laser Scanning
Authors: Wu Linlin , Shi Yongjun , Zhang Fanyi , Zhou Yufeng , Ding Zhentian , Lv Shixin , Xu Lin
Published: September 2022

Urban forest carbon sequestration represents an important component of the global forest carbon pool; however, accurate measurements are limited by the inability of existing field stand models to match the specificity of urban greening species. Herein, canopy volume, carbon stock, and the biomass expansion factor (BEF) of 30 Koelreuteria paniculate trees were measured based on terrestrial laser scanning (TLS) and compared to the results of existing wood volume and carbon stock model measurements. The findings revealed that (1) TLS point cloud data were highly reproducible and accurate (root mean square error of tree height and diameter at breast height were ±0.35 m and ±0.33 cm, respectively). (2) Owing to human interference and cluttered urban environments, the BEF of urban greening tree species fluctuated irregularly, considerably different from that of natural forest stands. (3) Leaf carbon stocks were influenced by the size of the voxel. (4) Different tree measurement factors maintained variable degrees of influence on BEF (height under branch, volume of thick branch, crown width, and projected areas of tree-crown produced correlation coefficients of −0.64, 0.54, 0.45, and 0.43, respectively). Accordingly, the carbon stock and BEF of urban greening tree species can be accurately calculated via TLS without damage.
How Environmental Factors Affect Forest Fire Occurrence in Yunnan Forest Region
Authors: Zhu Zheng , Deng Xiaofan , Zhao Fan , Li Shiyou , Wang Leiguang
Published: September 2022

Forest fire is an ecosystem regulating factor and affects the stability, renewal, and succession of forest ecosystems. However, uncontrolled forest fires can be harmful to the forest ecosystem and to the public at large. Although Yunnan, China is regarded as a global hotspot for forest fires, a general lack of understanding prevails there regarding the mechanisms and interactions that cause forest fires. A logistic regression model based on fire points in Yunnan detected by satellite in 2005–2019 was used to estimate how environmental factors in local areas affect forest fire events. The results show that meteorology is the dominant cause of the frequent forest fires in the area. Other factors of secondary importance are the daily minimum relative humidity and the daily maximum temperature. When using the logistic regression model based on the data of fire points in Yunnan over the period 2005–2019, the key threshold for the daily minimum relative humidity is 28.07% ± 11.85% and the daily maximum temperature is 21.23 ± 11.15 °C for a forest fire probability of 50%. In annual and monthly dynamic trends, the daily minimum relative humidity also plays a dominant role in which combustible substance load remains relatively stable from January to March, and the impact on forest fire becomes greater in April, May, and June, which plays a secondary role compared with the interannual climate. The maximum daily temperature ranks third in importance for forest fires. At the county level, minimum relative humidity and maximum temperature are the top two factors influencing forest fires, respectively. Meanwhile, the differences in forest fire points between counties correspond to the pathways of the two monsoons. This study applies quantitative expressions to reveal the important environmental factors and mechanisms that cause forest fires. The results provide a reference for monitoring and predicting forest fires.
The Imprint of Droughts on Mediterranean Pine Forests
Authors: Royo-Navascues Maria , Martínez del Castillo Edurne , Tejedor Ernesto , Serrano-Notivoli Roberto , Longares Luis Alberto , Saz Miguel Angel , Novak Klemen , de Luis Martin
Published: September 2022

Triggered by frequent high temperatures and scarce precipitation, droughts are a recurrent phenomenon in the Mediterranean Basin, causing significant impacts on forests. We analyzed the effects of drought intensity, duration, and seasonality on tree growth by investigating the relationship between the Standardized Precipitation-Evapotranspiration Index (SPEI) at different time scales and tree-ring width (TRW) in three pine species (Pinus halepensis Mill., P. sylvestris L, and P. uncinata Ramond ex A.DC) throughout a dense dendrochronological network in the Mediterranean Basin. We used generalized linear mixed models to predict such values over the entire distribution of the analyzed species. Furthermore, in areas where the species coexist, we analyzed the same parameters to highlight differences in their responses to similar climatic conditions. Our results showed that the maximum intensity of drought-affected conifers occurred more in the southern areas of the Spanish Mediterranean coast, especially P. halepensis, with maximum values of r = 0.67, while in the rest of the study area, the intensity decreased with elevation; we obtained maximum values of r = 0.40 and r = 0.33 for P. sylvestris and P. uncinata, respectively. This spatial distribution was also related to the duration of the drought impacts, showing that areas with lower intensity had shorter durations (2–4 months). We observed a latitudinal pattern in the seasonality of the drought impacts, with earlier growing seasons at high elevations (June–August) and later ones in the semi-arid Mediterranean. Similar intensity impacts were found in P. halepensis and P. sylvestris coexistence zones, although P. halepensis had a much longer duration and an earlier beginning of seasonality. Higher intensity, duration, and seasonality of drought effects were observed for P. sylvestris in areas where P. sylvestris and P. uncinata are distributed sympatrically. Understanding the plasticity and climatic response of these common southern European species to different types of droughts is crucial in the context of climate change where droughts are increasing in frequency and intensity.
Investigation on Cutting Power of Wood–Plastic Composite Using Response Surface Methodology
Authors: Xu Wangyu , Wu Zhanwen , Lu Wei , Yu Yingyue , Wang Jinxin , Zhu Zhaolong , Wang Xiaodong
Published: September 2022

For the sake of improving the benefit of enterprise by reducing energy waste. RSM (response surface methodology) was used to investigated the cutting power of wood–plastic composite at different cutting conditions (rake angle, cutting speed, depth of cut, and flank wear). Based on the experimental results, a cutting power model with a high degree of fitting was developed, which can be used to predict cutting power and optimal cutting conditions. Meanwhile, the effects of rake angle, cutting speed, depth of cut, and flank wear and their interaction on the cutting power were probed by analysis of variance, and the significant terms were determined. Finally, the optimal cutting condition was obtained as follows: rake angle of 10°, cutting speed of 300 m/min, depth of cut of 1.5 mm, and flank wear of 0.1 mm. This parameter combination is suggested to be used for industrial manufacturing of wood–plastic composite in terms of the incredible machining efficiency and the lowest energy consumption.
Comprehensive Bioinformatics and Expression Analysis of TCP Transcription Factors in Liriodendron chinense Reveals Putative Abiotic Stress Regulatory Roles
Authors: Hwarari Delight , Guan Yuanlin , Li Rongxue , Movahedi Ali , Chen Jinhui , Yang Liming
Published: September 2022

As a magnoliid angiosperm, the Liriodendron chinense (Hamsl) Sarg in the Magnoliaceae family is susceptible to external environmental factors. The TEOSINTE BRANCHED 1/CYCLOIDEA/PROLIFERATING CELL FACTORS (TCP) proteins known for their growth and developmental biological roles have been identified in various plant species but not in the Liriodendron chinense. In this study, 15 TCP genes were identified in the L. chinense genome, and categorized into two classes, termed class I (PCF) and class II (CIN and CYC/TB1). A total of 14 TCP genes were located on the 10 chromosomes, and the remaining one, on a contig. Multispecies phylogenetic tree analysis supported the classification of identified LcTCP genes and exhibited that the expansion of the LcTCP gene family was before the angiosperm evolutionary divergence times. Additional gene duplication investigations revealed a purifying selection pressure during evolution history. Moreover, the LcTCP genes were also observed to have various cis-acting elements related to plant growth and development, phytohormone regulations, and abiotic stress responses. Gene expression pattern analysis also paraded that LcTCP genes play a crucial role in abiotic stress regulations. In particular, LcTCP1 in all stresses investigated. Overall, our findings suggest a pivotal role for the TCP gene family during external environmental stresses in L. chinense. This study will provide valuable information on the identification and function of the LcTCPs during abiotic stresses, paving the way for further research on the functional verification of L. chinense TCPs.
Leaf and Root Litter Species Identity Influences Bacterial Community Composition in Short-Term Litter Decomposition
Authors: Lu Ying , Zhang Liudong , Li Kun , Ni Ruiqiang , Han Rongchu , Li Chuanrong , Zhang Caihong , Shen Weixing , Zhang Zhongjun
Published: September 2022

Microorganisms play a crucial role in litter decomposition in terrestrial ecosystems. The leaf and fine root litters of Robinia pseudoacacia Linn., Quercus acutissima Carr., Pinus tabulaeformis Carr. and Pinus densiflora Sieb. were analysed using the nylon litter bag method and Illumina MiSeq high-throughput sequencing for the amplification of bacterial 16S rRNA V4–V5. We assessed the effects of leaf and root litter species on the bacterial community after one year’s decomposition. The results showed that (1) the remaining mass of fine root litter was smaller than that of the leaf litter for R. pseudoacacia and Q. acutissima, while the opposite result was found for P. tabulaeformis and P. densiflora. (2) The bacterial community structure in leaf litter was most highly correlated with the initial N content and N:P, while that in fine roots was most highly correlated with the lignin content. (3) The bacterial phyla Bacteroidetes, Acidobacteria and Gemmatimonadetes were significantly affected by litter and species, whereas the relative abundances of Firmicutes and Chloroflexi were only affected by litter tissues. The relative abundances of Acidobacteria, Firmicutes and Chloroflexi in fine root litter were higher than those in leaf litter, while the opposite result was found for Bacteroidetes. The bacterial genera Burkholderia-Paraburkholderia, Sphingomonas and Mucilaginibacter were affected by litter tissues (p < 0.05). The relative abundance of Burkholderia-Paraburkholderia in fine root litter was higher than that in leaf litter, while the opposite result was found for Bradyrhizobium, Sphingomonas and Mucilaginibacter. Pearson’s correlation analysis showed that the relative abundances of the dominant phyla and genera were affected by the initial litter properties, especially for Bacteroides, Acidobacteria, Burkholderia and Sphingomonas. These findings indicate that litter tissues and their interactions with species are more important than the species in shaping the bacterial diversity and community composition, which was affected by the initial chemical properties of the litter.
Impact of Feeding Probiotics on Blood Parameters, Tail Fat Metabolites, and Volatile Flavor Components of Sunit Sheep
Authors: Liu Ting , Zhang Taiwu , Zhang Yanni , Yang Le , Duan Yan , Su Lin , Tian Jianjun , Sun Lina , Wang Bohui , Jin Ye
Published: September 2022

Sheep crude tail fat has unique nutritional values and is used as a raw material for high-quality natural oil. The purpose of this study was to investigate the effects of probiotics on the metabolites and flavor of sheep crude tail fat. In this study, 12 Sunit sheep were randomly divided into an experimental group (LTF, basal feed + Lactiplantibacillusplantarum powder) and a control group (CTF, basal feed). The results of sheep crude tail fat analysis showed that blood lipid parameters were significantly lower and the expression of fatty acid synthase and stearoyl-CoA desaturase genes higher in the LTF group than in the CTF group (p < 0.05). Metabolomic analysis via liquid chromatography–mass spectrometry showed that the contents of metabolites such as eicosapentaenoic acid, 16-hydroxypalmitic acid, and L-citrulline were higher in the LTF group (p < 0.01). Gas chromatography–mass spectrometry detection of volatile flavor compounds in the tail fat showed that nonanal, decanal, and 1-hexanol were more abundant in the LTF group (p < 0.05). Therefore, Lactiplantibacillus plantarum feeding affected blood lipid parameters, expression of lipid metabolism-related genes, tail fat metabolites, and volatile flavor compounds in Sunit sheep. In this study, probiotics feeding was demonstrated to support high-value sheep crude tail fat production.
Extraction of Lycopene from Tomato Using Hydrophobic Natural Deep Eutectic Solvents Based on Terpenes and Fatty Acids
Authors: Kyriakoudi Anastasia , Tsiouras Alexandros , Mourtzinos Ioannis
Published: September 2022

The present study proposes a green extraction approach for the recovery of lycopene from tomato fruits. Different hydrophobic natural deep eutectic solvents (HNADESs) based on terpenes (i.e., menthol and thymol) and fatty acids (i.e., decanoic acid and dodecanoic acid) were prepared at different molar ratios, characterised in terms of density, rheological properties, and Fourier transform-infrared (FT-IR) spectroscopy, and were examined for their effectiveness to extract lycopene from tomato. Response surface methodology (RSM) was employed to optimise the extraction parameters, namely duration (min) and solvent:solid ratio (v/w). Spectrophotometry and RP-HPLC-DAD were used in order to monitor the process efficiency. The combination of decanoic acid and dodecanoic acid was found to exhibit comparable extraction capacity to acetone. Taking into account that the HNADESs used in the present study are considered green, biodegradable and of low cost, the obtained carotenoid rich extracts are expected to be of use in industrial food applications.
Bacteriocin Production by Escherichia coli during Biofilm Development
Authors: Fokt Hanna , Cleto Sara , Oliveira Hugo , Araújo Daniela , Castro Joana , Cerca Nuno , Vieira Maria João , Almeida Carina
Published: September 2022

Escherichia coli is a highly versatile bacterium ranging from commensal to intestinal pathogen, and is an important foodborne pathogen. E. coli species are able to prosper in multispecies biofilms and secrete bacteriocins that are only toxic to species/strains closely related to the producer strain. In this study, 20 distinct E. coli strains were characterized for several properties that confer competitive advantages against closer microorganisms by assessing the biofilm-forming capacity, the production of antimicrobial molecules, and the production of siderophores. Furthermore, primer sets for E. coli bacteriocins–colicins were designed and genes were amplified, allowing us to observe that colicins were widely distributed among the pathogenic E. coli strains. Their production in the planktonic phase or single-species biofilms was uncommon. Only two E. coli strains out of nine biofilm-forming were able to inhibit the growth of other E. coli strains. There is evidence of larger amounts of colicin being produced in the late stages of E. coli biofilm growth. The decrease in bacterial biomass after 12 h of incubation indicates active type I colicin production, whose release normally requires E. coli cell lysis. Almost all E. coli strains were siderophore-producing, which may be related to the resistance to colicin as these two molecules may use the same transporter system. Moreover, E. coli CECT 504 was able to coexist with Salmonella enterica in dual-species biofilms, but Shigella dysenteriae was selectively excluded, correlating with high expression levels of colicin (E, B, and M) genes observed by real-time PCR.
Fractal Theory in Thin Films: Literature Review and Bibliometric Evidence on Applications and Trends
Authors: Mwema Fredrick M. , Jen Tien-Chien , Kaspar Pavel
Published: September 2022

A bibliometric analysis of publications on fractal theory and thin films is presented in this article. Bibliographic information is extracted from the Web of Science digital database and the bibliographic mapping undertaken using VOSviewer software. Based on the analysis, there is a growing trend in research on the applications of fractal theory in thin film technology. The factors driving this trend are discussed in the article. The co-citation, co-authorship and bibliographic coupling among authors, institutions and regions are presented. The applications of fractal theory in thin film technology are clarified based on the bibliometric study and the directions for future research provided.
Gut Microbiome and Mycobiome Alterations in an In Vivo Model of Alzheimer’s Disease
Authors: D’Argenio Valeria , Veneruso Iolanda , Gong Chunmei , Cecarini Valentina , Bonfili Laura , Eleuteri Anna Maria
Published: September 2022

Gut microbiota has emerged as an important key regulator of health and disease status. Indeed, gut microbial dysbiosis has been identified in an increasing number of diseases, including neurodegenerative disorders. Accordingly, microbial alterations have been reported also in Alzheimer’s disease (AD), suggesting possible pathogenetic mechanisms contributing to the development of specific AD hallmarks and exacerbating metabolic alterations and neuroinflammation. The identification of these mechanisms is crucial to develop novel, targeted therapies and identify potential biomarkers for diagnostic purposes. Thus, the possibility to have AD in vivo models to study this microbial ecosystem represents a great opportunity for translational applications. Here, we characterized both gut microbiome and mycobiome of 3xTg-AD mice, one of the most widely used AD models, to identify specific microbial alterations with respect to the wild-type counterpart. Interestingly, we found a significant reduction of the Coprococcus and an increased abundance of Escherichia_Shigella and Barnesiella genera in the AD mice compatible with a pro-inflammatory status and the development of AD-related pathogenetic features. Moreover, the fungal Dipodascaceae family was significantly increased, thus suggesting a possible contribution to the metabolic alterations found in AD. Our data point out the strict connection between bacterial dysbiosis and AD and, even if further studies are required to clarify the underlining mechanisms, it clearly indicates the need for extensive metagenomic studies over the bacterial counterpart.
Development and Application of InDel Markers Linked to Fruit-Shape and Peel-Colour Genes in Wax Gourd
Authors: Huang Xiaochun , Wu Wenting , Su Liwen , Lv Haixuan , Cheng Zhikui , Yang Wenrui , Nong Lifeng , Liu Ting , Chen Yong , Wang Peng , Liu Zhengguo
Published: September 2022

The wax gourd is commonly grown in many countries because of its high nutritional and economic value. While the genes for the fruit shape and peel colour of wax gourd have been reported, the InDel markers linked to these genes remain undeveloped. In this study, the InDel markers linked to fruit-shape (Bch02G016830) and peel-colour (Bch05G003950) genes were developed from resequenced data. We used 120 inbred lines, 536 isolated populations, and 4 commercial hybrids to evaluate the validity and application value of the InDel markers. The accuracy rates of nine pairs of fruit-shape InDel markers (GX1-GX9) were 84.16–91.66% in 120 inbred lines. The accuracy rates of 27 pairs of peel-colour InDel markers (PS1-PS27) within approximately 3.0 Mb upstream and 3.0 Mb downstream of the peel-colour gene were 100% and those of 6 pairs of peel-colour InDel markers (PS28-PS33) within 3.0–20 Mb upstream and downstream of the peel-colour gene were 55.83–90% in 120 inbred lines. The purity of four commercial hybrids determined using GX1, GX2, PS13, and PS14 was highly consistent with the field results for purity determination. Our results provide important information for genetic linkage map construction, molecular-marker-assisted selective breeding, and purity determination of wax gourd hybrids.
Intensive Care Unit Nurses’ Perceptions of and Coping Strategies for Motherhood Experiences: A Qualitative Study
Authors: Wu Hui-Chuan , Peng Yueh-Chu , Wang Hsiu-Hung
Published: September 2022

This qualitative study explored the perception of intensive care unit nurses in relation to their motherhood experiences and coping strategies. Ten intensive care unit nurses (aged 28–37 years) with children under 3 years old were recruited. In-depth 90-min interviews were conducted, and the contents of the audio recordings were translated into verbatim transcripts. From the results of the research analysis, three themes were identified: challenges and conflicts of motherhood, dilemma in life and work balance, and maternal engagement. The “challenges and conflicts of motherhood” and “dilemma in life and work” represent the maternal experiences, while “maternal engagement” is the coping strategy used. To establish a friendly working environment and policies, nursing managers should consider improving the friendliness of work units and encourage co-workers to support each other in the hospital.
Job Motivation, Burnout and Turnover Intention during the COVID-19 Pandemic: Are There Differences between Female and Male Workers?
Authors: Paredes-Aguirre Milton Ismael , Barriga Medina Holger Raúl , Campoverde Aguirre Ronald Enrique , Melo Vargas Ester Rebeca , Armijos Yambay Mary Betty
Published: September 2022

The working conditions during COVID-19 highlight the relevance of workers and their occupational health and well-being. The pandemic has caused adverse effects on workers and sharpened social and economic problems, such as a gender gap. In this study, with a multisector sample of 1044 Ecuadorian workers, we present a gender analysis where we evaluate how burnout can mediate the relationship between motivation and workers’ intention to leave their jobs in the COVID-19 context. To test the proposed hypothesis, structural equation model (SEM) was used. In the proposed conceptual model, turnover intention was considered as the dependent variable, the two dimensions of motivation (intrinsic and extrinsic) were the independent variables and burnout was tested as a mediating variable. Consistent with pre-COVID-19 research, our findings confirm the incidence of job motivation on burnout and turnover intention. Additionally, through Sobel’s criteria, we determine that burnout has a mediating effect between job motivation and turnover intention. In terms of gender, we find different results for female and male workers through critical ratios. Our study indicates that female and male workers’ burnout and turnover intentions levels are different when intrinsic motivation is present. In contrast to pre-COVID-19 studies that indicated no gender differences on these variables, we associate these results to gender roles in lockdown conditions during the pandemic.
Is Sacubitril/Valsartan Able to Change the Timing for Implantation of Cardiac Devices in Heart Failure with Reduced Ejection Fraction?
Authors: Nogueira Marta Afonso , Brochado Marisa , Nabais Inês , Batista Élia , Matias Carla , Proença Gonçalo
Published: September 2022

Aims: The aim of this study was to evaluate the impact of sacubitril/valsartan on left ventricular (LV) reverse remodeling, potentially modifying the timing for cardiac device implantation in heart failure with reduced ejection fraction (HFrEF), which has not been specifically addressed. Methods and results: A secondary data analysis of a prospective cohort of HFrEF patients was conducted. Inclusion criteria: patients who started sacubitril/valsartan between November 2017 and August 2019 after previous optimal medical therapy. Primary endpoint: time to achieve LV Ejection Fraction (EF) > 35%. Kaplan–Meier was used to estimate median time and Cox regression model to investigate the patients’ characteristics associated with event incidence rate. In total, 48 patients were included, with a mean age of 72.5 years, predominantly male (70.8%). From the initial 48 patients with LVEF ≤ 35%, 27 (56%) reached LVEF > 35%, in a median time of 11.3 months (95% confidence interval [95%CI]: 9.4–19.6). In multivariate analysis, baseline LVEF between 30 and 35% was associated with increased cumulative incidence of attaining LVEF > 35% (Incidence rate ratio = 3.9; 95%CI: 1.6–9.9; p-value = 0.004). Conclusion: We observed an improvement in LVEF to >35% in the majority of patients who switched to sacubitril/valsartan, illustrating its role in cardiac remodeling. We speculate that this improvement may allow delaying implantation of Cardioverter-Defibrillator/Cardiac Resynchronization Therapy.
Anthocyanin Composition in Cabernet Sauvignon Grape Skins: Effect of Regulated Deficit Irrigation in a Warm Climate
Authors: Aris Gonzalo , Cuneo Italo F. , Pastenes Claudio , Cáceres-Mella Alejandro
Published: September 2022

The influence of regulated deficit irrigation on the anthocyanin composition in Cabernet Sauvignon grape skins throughout ripening and when grown in a warm geographic area for two consecutive seasons was investigated. The assay was carried out on own-rooted Cabernet Sauvignon plants maintained under three irrigation regimes (i.e., T1 = 12 L h−1 (90% of ETp), T2 = 6 L h−1 (60% of ETp) and T3 = 2 L h−1 (30% of ETp)) from veraison until harvest. The results showed that the concentration of total anthocyanins varied among the three groups. In terms of the different fractions of anthocyanins, mild water stress generated slight changes with a different behavior between the 2014 and 2015 seasons, although the pattern of accumulation was similar. The trihydroxylated anthocyanins were much higher in concentration than the dihydroxylated counterparts in both seasons, with no significant differences among irrigation treatments. The water status did not produce differences in terms of the different anthocyanin proportions at harvest, which could indicate that the different irrigation treatments did not induce a greater accumulation of one or another type of anthocyanin.
Nutritional Composition and In Vitro Antioxidant Activities of Seed Kernel and Seed Oil of Balanites roxburghii: An Underutilized Species
Authors: Yadav Guggalada Govardhana , Murthy Hosakatte Niranjana , Dewir Yaser Hassan
Published: September 2022

The seed kernel of Balanites roxburghii Planch., an underutilized species, yields a substantial amount of oil and has an impressive fatty acid profile. Both seed cake and seed oil have the potential to be rich nutritive sources. With this view, in the present study, nutritive profiling of seed kernel and seed oil including HPLC quantification of tocopherols and phytosterols has been done. Further, the total phenolic content and antioxidant activities of seed kernel and oil have also been analyzed. The seed kernel showed good proximate composition with 43.20% of oil and 10.96% of protein with a good amount of macro- and microelements. The seed oil possesses 5.36 mg/kg of carotenoids and 7.29, 1.79, and 0.72 mg/100 g of α, β + γ (together), and δ-tocopherols, respectively. The β-Sitosterol is the major phytosterol in the oil with 126.90 mg/100 g oil followed by stigmasterol and campesterol together (40.78 mg/100 g oil). It is also rich in squalene (17.45 mg/100 g oil). Oleic acid (56.38%), linoleic acid (18.77%), and palmitic acid (17.79%) were found to be the major fatty acids. Seed cake and seed oil possess significant antioxidant activities with 2.72 mg Gallic acid equivalent (GAE)/g and 8.90 mg GAE/100 g total phenolic content, respectively. Even though seed kernels contain some amount of anti-nutritional factors, they can be minimized by practicing appropriate food processing techniques. Considering all these facts, such as availability, good quality oil, proteins, and elemental composition, seeds of B. roxburghii could be considered a reliable food source to increase the food base of people and to get a variety of nutrients.
Consumption of JUUL vs. Other E-Cigarette Brands among U.S. E-Cigarette Users: Evidence from Wave 5 of the PATH Study
Authors: Wang Yu , Duan Zongshuan , Weaver Scott R. , Popova Lucy , Spears Claire A. , Ashley David L. , Pechacek Terry F. , Eriksen Michael P. , Huang Jidong
Published: September 2022

This study examines the use of JUUL vs. other e-cigarette brands among U.S. youth (12–17 years), young adult (18–24 years), and adult (25 years and above) e-cigarette users. Data were from the Population Assessment of Tobacco and Health (PATH) study Wave 5 survey (2019). The study population was past 30-day e-cigarette users who knew the brand of e-cigarettes they usually/last used (N = 2569). JUUL use was reported by 65.2% of youth, 60.7% of young adult, and 25.6% of adult e-cigarette users in our study sample. The share of JUUL consumed in the past 30 days, measured by the total number of puffs, was 15.4% by youth, 55.5% by young adults, and 29.1% by adults. By contrast, the share of other e-cigarettes consumed was 4.2% by youth, 28.9% by young adults, and 66.9% by adults. Youth JUUL users were more likely to use e-cigarettes within 30 min after waking (aOR = 2.30, 95% CI: 1.12–4.75) than youth users of other brands of e-cigarettes. Additionally, youth e-cigarette users who currently smoked cigarettes were less likely to use JUUL (aOR = 0.55, 95% CI: 0.30–0.99). This study concludes that JUUL consumption was disproportionally higher among youth and young adults in the U.S. in 2019.
Association between Productive Roles and Frailty Factors among Community-Dwelling Older Adults: A Cross-Sectional Analysis
Authors: Yokoyama Kazuki , Ihira Hikaru , Matsuzaki-Kihara Yuriko , Mizumoto Atsushi , Miyajima Ryo , Sasaki Takeshi , Kozuka Naoki , Ikeda Nozomu
Published: September 2022

The employment rate of older people in Japan is expected to increase in the future owing to the increase in the retirement age. Preventing frailty is imperative to maintaining productive roles of older adults. Therefore, this study aimed to examine the association between productive roles and frailty factors among community-dwelling older adults. A total of 135 older adults, enrolled in 2017, participated in the study. Productive roles and domains related to frailty were measured. We measured usual gait speed and grip strength for the physical domain; Mini-Mental State Examination (MMSE) and Geriatric Depression Scale (GDS-15) scores for the cognitive and mental domains; and social role and group activity for the social domain. Multivariate-adjusted logistic regression models revealed that having productive roles was associated with faster usual gait speed (odds ratios [OR] = 1.05; 95% confidence interval [CI], 1.01–1.08; p = 0.005) and lower GDS-15 score (OR = 0.79; 95% CI, 0.64–0.97; p = 0.023). These results suggest that health promotion to maintain gait speed and prevent depressive symptoms may contribute to maintaining productivity in community-dwelling older adults.
Factors Associated with Quit Intentions among Adult Smokers in South Korea: Findings from the 2020 ITC Korea Survey
Authors: Han Minjung , Seo Donghee , Kim Yeol , Seo Hong Gwan , Cho Sung-il , Lee Sungkyu , Lim Sujin , Kaai Susan C. , Quah Anne C. K. , Yan Mi , Xu Steve S. , Fong Geoffrey T.
Published: September 2022

Background: South Korea has made substantial progress on tobacco control, but cigarette smoking prevalence is still high. Previous studies were conducted before the use of nicotine vaping products (NVPs) or heated tobacco products (HTPs) became popular. Thus, whether the concurrent use of NVPs or HTPs affects quit intentions among Korean smokers remains a question that needs to be explored. This study aims to identify predictors of quit intentions among cigarette-only smokers and concurrent users of cigarettes and NVPs or HTPs. Methods: Data were from the 2020 International Tobacco Control Korea Survey. Included in the analysis were 3778 adult cigarette smokers: 1900 at-least-weekly exclusive smokers and 1878 at-least-weekly concurrent smokers and HTP or NVP users. Bivariate and multivariable logistic regression analyses were conducted. Results: Quit intentions were reported by 66.4% of respondents. Factors significantly associated with quit intentions included younger age, having a spouse/partner, lower nicotine dependence, reporting a past quit attempt, regretting starting smoking, believing that smoking had damaged health, worrying that smoking will damage future health, and perceiving health benefits of quitting. Current use of NVPs or HTPs was not significantly associated with quit intentions. Conclusions: This study contributes the following to current literature: intrinsic health-related beliefs were more important than societal norms in shaping quit intentions. These findings should be considered in shaping future smoking cessation policies, such as reinforcing education programs that emphasize the benefits of quitting for personal health reasons, lowering nicotine dependence, and encouraging multiple quit attempts and successful quitting.
Effect of Six-Week Speed Endurance Training on Peripheral Fatigue
Authors: Jereb Blaz , Strojnik Vojko
Published: September 2022

(1) Speed endurance training (inducing a high blood lactate concentration) delays excitation–contraction coupling impairment, thus providing more space for high-frequency fatigue to occur in the early stage of maximal concentric actions. This study aimed to test the hypothesis that the maintenance type of speed endurance training may shift peripheral fatigue from low-frequency to high-frequency fatigue after the 15 s long Wingate test. (2) Six students of physical education performed the corresponding training for six weeks. Before and after this period, they were tested for low- and high-frequency fatigue after the 15 s long Wingate test; additionally, their blood lactate concentrations, maximal cycling power, work, fatigue index, and muscle twitch responses were also tested. (3) The training increased the maximal cycling power and work (p < 0.001 and p < 0.01, respectively) with minor changes in the mean fatigue index and blood lactate concentration (both p > 0.05). Low-frequency dominant fatigue before the training showed a trend toward high-frequency dominant fatigue after the training (p > 0.05). (4) The results showed that the 15 s Wingate test failed to induce significant high-frequency fatigue. Even though it displayed a substantial fatigue index, the changes in favor of high-frequency fatigue were too small to be relevant.
Occupational Safety and Health Staging Framework for Decent Work
Authors: Schulte Paul A. , Iavicoli Ivo , Fontana Luca , Leka Stavroula , Dollard Maureen F. , Salmen-Navarro Acran , Salles Fernanda J. , Olympio Kelly P. K. , Lucchini Roberto , Fingerhut Marilyn , Violante Francesco S. , Seneviratne Mahinda , Oakman Jodi , Lo Olivier , Alfredo Camila H. , Bandini Marcia , Silva-Junior João S. , Martinez Maria C. , Cotrim Teresa , Omokhodion Folashade , Fischer Frida M.
Published: September 2022

The 2030 United Nations Goal 8 for sustainable development focuses on decent work. There is utility in identifying the occupational safety and health aspects of Goal 8, as they pertain to the four pillars of decent work: job creation, social protection, rights of workers, and social dialogue. A workgroup of the International Commission on Occupational Health and collaborators addressed the issue of decent work and occupational safety and health (OSH) with the objective of elaborating a framework for guidance for practitioners, researchers, employers, workers, and authorities. This article presents that framework, which is based on an examination of the literature and the perspectives of the workgroup. The framework encompasses the intersection of the pillars of decent (employment creation, social protection, rights of workers, and social dialogue) work with new and emerging hazards and risks related to various selected determinants: new technologies and new forms of work; demographics (aging and gender); globalization; informal work; migration; pandemics; and OSH policies and climate change. The OSH field will need an expanded focus to address the future of decent work. This focus should incorporate the needs of workers and workforces in terms of their well-being. The framework identifies a starting point for the OSH community to begin to promote decent work.
Respiratory Symptoms and Skin Sick Building Syndrome among Office Workers at University Hospital, Chiang Mai, Thailand: Associations with Indoor Air Quality, AIRMED Project
Authors: Surawattanasakul Vithawat , Sirikul Wachiranun , Sapbamrer Ratana , Wangsan Kampanat , Panumasvivat Jinjuta , Assavanopakun Pheerasak , Muangkaew Supang
Published: September 2022

Sick building syndrome (SBS) is the term used to describe the medical condition in which people in a building suffer from symptoms of illnesses for no apparent reason. SBS was found to be associated with indoor air quality (IAQ) but there are a variety of determinants (buildings, in particular). Identifying and controlling factors related to SBS is crucial for improving worker health and efficiency. A cross-sectional study was conducted to investigate (1) the prevalence of respiratory symptoms and skin SBS and (2) their associations with IAQ among office workers in administrative offices in an academic medical institute. A self-reporting questionnaire assessing the worker’s characteristics, working conditions, and perception of working environments was used. The building assessment was via a walk-through survey and IAQ measurement. Of 290 office workers, 261 (90%) in 25 offices of 11 buildings took part in the survey. The highest prevalence of SBS was nasal symptoms (25.3%). We found that to reduce the risk of SBS, optimal air temperature levels in air-conditioned offices should be lower than 23 °C, with relative humidity between 60% and 70%. Lowering indoor CO2 levels below 700 ppm may be indicative of adequate ventilation to prevent SBS by reducing worker discomfort and indoor contaminants (e.g., formaldehyde).
Acceptability of a Smartphone Application to Enhance Healthcare to Female Genital Mutilation Survivors in Liberia: A Qualitative Study
Authors: Nordmann Kim , Martínez-Pérez Guillermo Z. , King Mandella , Küpper Thomas , Subirón-Valera Ana Belén
Published: September 2022

In Liberia, female genital mutilation/cutting (FGM/C) is a legally allowed initiation ritual in the secret Sande society. Due to the secrecy, Liberian healthcare providers receive little education on FGM/C and its health consequences. As mobile learning approaches proved to efficiently increase providers’ knowledge and skills, a mobile application (‘app’) was designed to support self-learning, decision-making, and the follow-up of FGM/C survivors’ health. The ‘app’ was introduced in a capacity-building project in 2019 and evaluated through this qualitative study to assess healthcare provider’s needs and acceptance. We conducted 22 semi-structured interviews and eight focus group discussions with 42 adult healthcare providers in three Liberian counties. A thematic approach grounded in descriptive phenomenology guided data analysis and led to three main themes: the ‘app’, mobile learning and health education, and personal impression. Healthcare providers judge the ‘app’ useful to broaden their knowledge and skills, which might lead to better FGM/C detection and management. The ‘app’ might further facilitate patient and community education about the negative health consequences of FMG/C, possibly contributing to a reduction of FGM/C prevalence.
Utilization of Mental Health Support Systems in the Aftermath of Disasters in Japan: Statistical Data of the Miyagi Disaster Mental Health Care Center
Authors: Fukuchi Naru , Chiba Shusaku
Published: September 2022

Large-scale natural disasters have a significant effect on residents’ mental health. The Miyagi Disaster Mental Health Care Center (DMHCC) was established as a long-term mental health care center in response to the 2011 Great East Japan Earthquake and Tsunami (GEJE). Although six DMHCCs have been established in Japan, their exact role and functioning are still unclear. This study aimed to explore which population used the center in each recovery phase. Logistic regression was performed to identify the residents’ characteristics according to the consultation pathways using the data collected by the Miyagi DMHCC. These data included personal information of the residents who were supported by the center from 2013 to 2018. The working-age unemployed men sought help by themselves, and the isolated older females were supported by home visits through the health survey. Long-term mental health care centers should observe community recovery and provide appropriate support. The implications of this result and future research directions are discussed.
Night Work and Sustainable Working Life—A Prospective Trajectory Analysis of Swedish Twins
Authors: Ropponen Annina , Wang Mo , Raza Auriba , Narusyte Jurgita , Svedberg Pia
Published: September 2022

The aim was to investigate the changes in sustainable working life over 10–13 years of follow-up and the effect of baseline night work. Data from the Swedish national registers were used to define sustainable working life. Survey data in the 1998–2003 “SALT” with 34,680 twins or in the 2004–2006 “STAGE” with 19,637 twins were utilized to assess night work at baseline. Group-based trajectory and multinomial regression models were applied. The results of the SALT cohort yielded five trajectory solutions: stable sustainable working life (40%), stable lack of sustainable working life (25%), later decreasingly sustainable working life (15%), increasingly sustainable working life (14%), and early decreasingly sustainable working life (7%). In the STAGE cohort, four trajectories were detected: stable sustainable working life (83%), decreasingly sustainable working life (7%), stable lack of sustainable working life (5%), and increasing sustainable working life (5%). Night work was associated with the decreasing or increasing sustainable working life in the trajectory groups. To conclude, the largest parts of both cohorts followed trajectories of stable sustainable working lives. Night work was associated with both the trajectories of decreasing and increasing sustainable working lives.