bluuebunny/crossref_metadata_2025 huggingface dataset:
Robot-assisted radical prostatectomy in patients after endoscopic surgeries on the prostate
Authors: Guliev B. G. , Ilyin D. M. , Kharchenko P. V. , Talyshinskiy A. E. , Krylov O. A.
Published: March 2024

Background. In literature, data on the results of robot-assisted radical prostatectomy (RARP) in patients after transurethral resection of the prostate (TURP) are contradictory.

Aim. To evaluate surgical, functional, and oncological outcomes of RARP after TURP.

Materials and methods. At the Urology Center of the Mariinsky Hospital (Saint Petersburg), RARP was performed on 410 patients. Among them, 28 (6.8 %) patients (1st group) previously underwent TURP due to infravesical obstruction. Among them, 18 (64.3 %) patients were diagnosed with prostate cancer after pathomorphological examination of the tissue resected during TURP, and on them RARP was performed on average 3.2 months later. In 10 (35.7 %) patients, prostate cancer was diagnosed during transrectal biopsy due to increased prostate-specific antigen level; on them RARP was performed on average 42.0 months after TURP. The following parameters were evaluated: operative time, time of bladder neck reconstruction and urethrovesical anastomosis formation, blood loss volume, tumor pathological stage, Gleason score, surgical margin status, rates of urine continence and preservation of erectile function.

Results. Mean operative time was higher in the 1st group compared to the 2nd: 210 ± 36 min versus 180 ± 25 min (р <0.0001). In the 1st group compared to the 2nd, reconstruction of bladder neck was necessary more frequently (82.1 % versus 10.7 %; р <0.0001), urethrovesical anastomosis took longer time (32 ± 2.3 min versus 24.5 ± 3.1 min; р <0.0001), mean blood loss volume was higher (240 ± 39 mL versus 170 ± 32 mL; р <0.0001). Frequencies of positive surgical margin were 14.3 and 10.7 % respectively in the 1st and 2nd groups (р = 0.840). Frequencies of all complications were 28.6 and 21.4 %, respectively. Severe complications (≥IIIb grade per the Clavien classification) were observed in 2 (7.1 %) patients in both groups. Frequency of anastomosis stricture after surgery was significantly higher in the 1st group: in 2 (7.1 %) and 1 (3.6 %) case, respectively (р <0.05). In the 1st group, total urinary continence was achieved in 14 (50.0 %), 20 (71.5 %), 22 (78.5 %) and 25 (89.3 %) patients at early and 3-, 6and 12-month follow-up after RARP; in the 2nd group, it was achieved in 18 (64.3 %), 22 (78.6 %), 24 (85.7 %) and 26 (92.9 %) patients in the same follow-up periods. After 6 and 12 months, in the 1st group among 15 (53.6 %) patients with normal initial erectile function, satisfactory erectile function was preserved in 46.7 and 93.3 % of patients; in the 2nd group among 19 (67.8 %) patients, in 57.8 and 94.7 % patients, respectively.

Conclusion. RARP after TURP is a relatively complicated surgical intervention with long operative time and high blood loss volume. However, functional and short-term oncological outcomes of RARP in these patients do not differ at 12 months.
Machine Learning System Development in Information Systems Development Praxis
Authors:   University of Turku, Tampere University, Laato Samuli , Minkkinen Matti ,   University of Turku, Mäntymäki Matti ,   University of Turku, Dennehy Denis ,   Swansea University
Published: March 2024

Advancements in hardware and software have propelled machine learning (ML) solutions to become vital components of numerous information systems. This calls for research on the integration and evaluation of ML development practices within software companies. To investigate these issues, we conducted expert interviews with software and ML professionals. We structured the interviews around information systems development (ISD) models, which serve as conceptual frameworks that guide stakeholders throughout software projects. Using practice theory, we analyzed how software professionals perceive ML development within the context of ISD models and identified themes that characterize the transformative impact of ML development on these conceptual models. Our findings show that developer-driven conceptual models, such as DevOps and MLOps, have been embraced as common frameworks for developers and management to understand and guide the ML development processes. We observed ongoing shifts in predefined developer roles, wherein developers are increasingly adopting ML techniques and tools in their professional work. Overall, our findings underscore that ML technologies are becoming increasingly prominent in software projects across industries, and that the incorporation of ML development in ISD models is an ongoing, largely practice-driven, process.
Rebel Foods’ Cloud Kitchen Technologies: Food for Thought?
Authors:   Indian Institute of Management Ahmedabad, Lahiri Saikat , Bose Indranil ,   Indian Institute of Management Ahmedabad, Majumdar Adrija ,   Indian Institute of Management Ahmedabad
Published: March 2024

This case study examines the India based cloud kitchens and food services provider Rebel Foods’ technology platforms. We document the development of the company from its foundation in 2004 and the role played by technology in enabling its various lines of business. We describe in detail the technology stack that drives the operations at Rebel Foods. We also present various emerging technologies such as artificial intelligence (AI), machine learning (ML), robotic process automation (RPA), blockchain, and augmented reality (AR) that may be utilized by Rebel Foods to increase efficiency, build customer engagement, and improve sales growth and profitability. We critically examine Rebel Foods’ current approach to technology and analyze the various technology options that the company may consider to drive its future strategy.
ADMISSIBILITY OF EVIDENCE IN THE CRIMINAL PROCEDURE LAW OF THE EUROPEAN UNION AND ITS IMPACT ON CRIMINAL JUSTICE IN UKRAINE
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Pohoretskyi M.A. , Lysachenko Y. I. ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: March 2024

The article is devoted to the study of admissibility of evidence in the criminal procedural law of the European Union and its impact on criminal justice in Ukraine. Authors analyze the legislative regulation and scientific approaches to determining the admissibility of evidence in European countries. The article establishes that there is no unity among the EU member states in determining the legal nature of the admissibility of evidence in criminal proceedings, namely: there are legal systems that strictly filter the information admitted to the trial (the so-called «controlled systems»), and legal systems that leave it to the discretion of the judge to assess the expediency of ignoring illegal evidence («free evidence systems»). Beyond this general distinction, evidence laws vary considerably among countries. As well as the rules of obtaining and admissibility of different types of evidence (witness testimony, interception of telephone conversations, etc.). Authors emphasize that with the increasing volume and importance of cross-border investigations in the European Union, ensuring the admissibility of evidence obtained in another Member State becomes crucial for both effective law enforcement and the protection of fundamental rights. National prosecuting authorities often investigate crimes in which part of the evidence is located abroad (a witness is abroad, the crime was committed by passing through a foreign territory, the offender crossed the border, or the crime was committed in a digital environment, etc.) In accordance with Article 6 of the European Convention on Human Rights (ECHR) and Articles 47 and 48 of the Charter of Fundamental Rights of the European Union, it is necessary to ensure that evidence obtained during cross-­border investigations does not lead to its illegal or unfair use. It is concluded that the implementation of international standards, the study of the judicial practice of the European Union and the results of the work of scientists will contribute to the updating of the criminal procedural legislation of Ukraine, but it is important to take into account the national peculiarities of criminal proceedings.
Analysis of the availability of bronchodilators and anti-inflammatory drugs for patients with chronic obstructive pulmonary disease
Authors: Orlova E. A. , Petrov V. I. , Dorfman I. P. , Shatalova O. V. , Orlov M. A.
Published: March 2024

Background. The study of drug availability for patients with chronic obstructive pulmonary disease (COPD) represents one of the priority tasks in the organization of effective counteraction to COPD in the Russian Federation.

Objective: to assess drug prices, affordability, and availability for COPD patients.

Material and methods. The analysis of drug availability for COPD patients was carried out according to the methodology of the World Health Organization and Health Action International (WHO/HAI). Bronchodilator and anti-inflammatory therapy of originator brands and lowestpriced generics was evaluated. The consumption volume of the studied drugs was also analyzed using the ATC/DDD (Anatomical Therapeutic Chemical classification / defined daily dose) pharmacoepidemiologic methodology over a three-year period (from 2020 to 2022), taking into account their share of total DDD (drug utilization analysis, DU90%).

Results. According to the results of DU90% analysis, the most purchased drugs for bronchodilator and anti-inflammatory therapy for all the years under study were drugs from the groups of short-acting bronchodilators (salbutamol, fenoterol, ipratropium bromide + fenoterol) and inhaled glucocorticoids (budesonide, beclomethasone). The obtained data were confirmed by the results of the physical availability study. Thus, the highest percentage of physical availability was for short-acting inhaled beta-2-agonists (SABA) (salbutamol). Analysis of drug affordability also revealed a tendential superiority of SABA and short-acting anticholinergics over baseline bronchodilators and antiinflammatory drugs.

Conclusion. Low affordability of the main drugs of baseline therapy contributes to the burden of COPD and necessitates improvement of drug supply mechanisms for individuals, especially those with low material income, which in the long term will significantly reduce the costs of the healthcare system for the treatment of these patients by decreasing the severity and frequency of exacerbations.
Sodium Glucose Co-Transporter 2 Inhibitors and the Cardiovascular System: Current Knowledge and Future Expectations
Authors: Boutsikos Ioannis ,   Department of Therapeutics, Alexandra General Hospital, National and Kapodistrian University of Athens, Athens, Greece, Beltsios Eleftherios ,   Department of Cardiothoracic, Transplant and Vascular Surgery, Hannover Medical School, Hannover, Germany, Schmack Bastian ,   Department of Cardiothoracic, Transplant and Vascular Surgery, Hannover Medical School, Hannover, Germany, Pantazopoulos Ioannis ,   Department of Emergency Medicine, Medical School, University of Thessaly, Larissa, Greece, Chatzis Dimitrios G ,   School of Medicine, European University of Cyprus, Nicosia, Cyprus
Published: March 2024

Diabetic cardiomyopathy is a well-recognized clinical entity and reflects a complex relationship between metabolic substrates and myocardial function. Sodium glucose co-transporter 2 (SGLT2) inhibitors are antidiabetic agents that are found to exert multiple cardioprotective effects. Large clinical trials showed their beneficial effects on patients with heart failure, reducing the rates of rehospitalizations and improving kidney function. The aim of this review is to summarize the latest evidence in the literature regarding the multiple effects of SGLT2 inhibitors on patients across the spectrum of cardiovascular diseases.
Regional Planning for Aging in Place: Older Adults' Perceptions of Needs and Awareness of Aging Services in Washington State
Authors: Bolkan Cory , Weaver Raven H. , Kim Eunsaem , Mandal Bidisha
Published: March 2024

Aging in place (AIP), or being able to maintain independence in one's home and community, will be a big challenge for older adults in coming decades. As interest in AIP, age‐friendly policies, and livable community initiatives grows, successful policy planning should be based on the perspectives of older adults, especially those from marginalized communities with limited resources. We surveyed 252 community‐dwelling older adults (M = 73.61; SD = 8.44) via computer‐assisted‐telephone interviews about their health, support needs, access to services/supports, and awareness of the local aging services organization. Nearly one‐third of participants (31%) reported having unmet support needs for their activities of daily living. The most prevalent unmet needs were related to home maintenance tasks (i.e., home repairs, yard work, housekeeping, and other services). Regression analyses revealed that poor health (physical and mental) increased risk for unmet needs, but adequate knowledge of aging services lowered the risk (all p < 0.05). Most participants were not familiar with the local aging services organization and nearly one‐quarter did not know where to get the help they needed. Content analysis revealed four pathways of anticipated help: (1) reliance on friends/family, (2) general expectations that government, social services, or community support will be available, (3) pursuit of non‐specific searches for support, and (4) referrals from medical professionals. Raising awareness about affordable community‐based aging services, bolstering cross‐sector engagement, and proactively investing in age‐friendly community initiatives are necessary actions toward effectively planning for future support needs and addressing the comprehensive AIP needs of diverse older adults.
Современное высшее образование в России
Authors: Ренсков Д.А.
Published: March 2024

Работа исследует о вопрос об современной высшей образовании в России.
MMALA: Developing and Evaluating a Maturity Model for Adopting Learning Analytics
Authors: Freitas Elyda , Fonseca Fernando , Garcia Vinicius , Pontual Falcão Taciana , Marques Elaine , Gašević Dragan , Ferreira Mello Rafael
Published: March 2024

Learning analytics (LA) adoption is a challenging task for higher education institutions (HEIs) since it involves different aspects of the academic environment, such as information technology infrastructure, human resource management, ethics, and pedagogical issues. Therefore, it is necessary to provide institutions with supporting instruments to deal with these challenges. Although there has been much research on factors that are associated with the adoption of LA in HEIs, there has been much less research on specific models that can be used to guide actual adoption. In this sense, we developed MMALA, a Maturity Model for Adopting Learning Analytics. It is a guide that describes the necessary practices for taking the first steps in this area and enables institutions to reach higher levels of maturity in LA use, culminating in an organized and systematic adoption. In this paper, we describe the development process of MMALA, focusing on the model evaluation, which used both the questionnaire and the expert opinion method. MMALA can also give institutions an overview of their current situation regarding LA adoption. In this sense, we present the results of the maturity evaluation of three Brazilian HEIs using MMALA.
Evaluation of the Effectiveness of Museum Education in Virtual Environment with 360° Videos
Authors: İşlek Didem , Asiksoy Gülsüm
Published: March 2024

This study aims to evaluate the impact of virtual museum applications incorporating 360° videos on student achievement levels. In this context, a specialized educational environment was designed using 360° videos in a museum education course, and the effects on learning achievements were examined. Additionally, students' perceptions of the developed environment were assessed. Employing a mixed-methods approach, the research engaged both quantitative and qualitative methodologies. The sample consisted of students majoring in elementary education (N=32) and preschool education (N=29). The quantitative data collection process followed an experimental model with a post-test control group and a randomized design. Qualitative data were gathered through semi-structured interviews reflecting student opinions. The research findings indicate that virtual museum applications positively influence student achievement levels, particularly noting an enhanced interaction with applications incorporating 360° videos. Moreover, qualitative findings support that students perceive such museum education activities positively, indicating a positive impact on the learning process. Based on the results of this study, the following recommendations are proposed for the effective implementation of virtual museum education with 360° videos: Firstly, design virtual museum activities that align with learning objectives and actively engage students. Secondly, it is crucial to instruct students in navigating virtual museum environments using 360° video technology. Additionally, efforts should be made to provide accessible virtual museum experiences for all students. Future research endeavors may delve into a more detailed exploration of the long-term effects of 360° videos in virtual museum education on student learning and engagement. Furthermore, researchers could broaden their perspective by integrating virtual museum education with other teaching formats, such as field trips and hands-on activities.
Evaluation of Sports Achievements of Participants in Cheerleading Competitions by Rationalizing Refereeing
Authors: Synytsya Tetiana , Synytsya Sergiy , Rybalko Lina , Kornosenko Oksana , Zhamardiy Valeriy
Published: March 2024

Cheerleading is a popular sport that is developing and increasing the number of fans. Cheerleading is a subjective sport and therefore it requires a lot of attention. The aim of the study is to investigate, identify and scientifically substantiate effective ways of rationalizing the refereeing of cheerleading competitions. 105 cheerleading judges took part in the study. Based on the results of the survey, an experimental group of judges of II and III categories was formed, which consisted of 73 young judges (hereinafter referred to as novice judges), who were involved in the experiment. Among them, 35.6% have the II judge category, 64.4% – III. Among novice judges, 23.3% have 3 years of experience as judges, 42.5% – 2 years, the rest – 31.2% – 1 year. The conducted questionnaire of cheerleading judges showed that certain difficulties arise in the judging process: distraction of own athletes and their parents, judges or competition organizers (72.6%); a large number of athletes in the team (up to 24), a significant number of numbers in one nomination (11.0%); long and loud music (8.2%); violation of hygiene requirements (weak or significant lighting, unventilated room, draft, etc.) (8.2%). In addition, there is a need to store the performances in memory, for a qualitative assessment of all competitive performances. As a result of the conducted research, methodical recommendations were developed, as well as developed evaluation symbols and marks for use during competition that will help judges to qualitatively and fairly evaluate competitive performances; remember performances and correctly distribute participants.
The Usage of Scriptural Nativity Motifs in Early Greek and Slavonic Hymnography
Authors: Santos Marinas Enrique
Published: March 2024

In this article I will make a survey of the usage of the main nativity motifs that can be found in early Greek and Slavonic hymnography, such as the kata stichon hymns. Moreover, I will compare them with the nativity motifs that are mentioned in several works belonging to the homiletic literature, such as Pseudo-Chrysostom’s sermon known as In illud, Memor fui Dei, et delectatus sum or St. Proclus’ Oratio in natalem diem Domini, as well as with the apocryphal Gospels and Infancy Gospels. In this way, we can have an idea of the mutual references that are made between all those works, and of the different usage that they show.
Female Monastic Patronage in Medieval Georgia: Queen Tamar and Her Monastery in Tighva
Authors: Natsvlishvili Natia
Published: March 2024

Tighva Monastery was founded by Queen Consort Tamar, the daughter of David the Builder, a famous Georgian king who succeeded in uniting the country and making it a dominant regional power. According to the written sources, Tamar was married to Shah Manuchehr III, the Muslim ruler of Shirvan (modern Azerbaijan) around 1111, in order to “rule over Shirvan”. Tamar lived and reigned in the Muslim court for more than twenty years. Resulting from a need to secure a retirement home and final resting place, she initiated the construction of Tighva Monastery soon after her return to Georgia in the 1140s. As her husband Manuchehr died in 1160, it seems that Tamar left Shirvan still a married woman, for unknown reasons. Tamar cut ties with her family and spent the remainder of her life as a nun in Tighva. The Church of the Crucifixion in Tighva Monastery, which represents the main focus of this paper, gives a good example of how the place occupied by women during the Divine Liturgy not only indicated their social status, but also determined their visibility, demonstrating how architecture could be used to establish the limits of physical appearance of royal women in the twelfth century Georgian monastic space.
The Effects of Dietary Supplement of Arthrospira platensis (Spirulina) as a Fishmeal Replacer on Growth Performance and Carotenoid Concentration in Buenos Aires Tetra (Aphyocharax anisitsi)
Authors: Rana Masud , Das Mousumi , Parvin Sehnaz , Kabita Sk.
Published: March 2024

Background: Arthrospira platensis (Spirulina) is a potential ingredient in aquafeed for containing high protein, minerals, vitamins and pigments which provide nutritional value to fish. It is a growth promoter and carotenoid source in non-ornamental fishes. Methods: To evaluate the potential of A. platensis (Spirulina) as a growth promoter and carotenoid source for transferring from the diets to the muscle and skin of Buenos Aires Tetra, Aphyocharax anisitsi, five experimental diets were prepared by replacing fishmeal, D0 (0%) (control), D25 (25%), D50 (50%), D75 (75%) and D100 (100%). The growth parameters like weight gain, length gain, specific growth rate and food conversion ratio were measured and carotenoid content in the muscle and skin of the fish was estimated. Result: At the end of the experiment, significantly (P less than 0.05) higher weight gain (WG), length gain (LG), specific growth rate (SGR) and feed conversion ratio (FCR) were observed in D50 and D75 diet groups compared to control and D100 where fishmeal was replaced by 21 g and 31.5 g spirulina respectively. The carotenoid content in the muscle and skin was also found to be highest in D75 compared to control. The findings of this experiment showed that A. platensis could replace up to 50% and 75% fishmeal in the diet of A. anisitsi for optimum growth and carotenoid accumulation in the muscle and skin.
Diversity Studies of Sclerotium rolfsii Sacc. Isolates Associated with Collar Rot of Soybean Through Molecular and Biochemical Approaches
Authors: Hiremath Ishwari G. , Jahagirdar Shamarao , Krishnaraj P.U. , Ashtaputre S.A. , Kambrekar D.N. , Priyanka K.
Published: March 2024

Background: Sclerotium rolfsii Sacc. is one of the potential soil-borne plant pathogens due to its significant loss in terms of yield and quality in several crop plants. In soybean the pathogen is associated with collar rot disease. Methods: Sixteen samples which were showing collar rot symptoms were collected from different soybean growing regions of the country and were subjected for isolation and purification. Molecular detection was carried out using ITS1/4 primers followed by phylogenetic analysis was performed using the MEGA 11 bioinformatics tool. Further, the biochemical test was made for oxalic acid production to determine the variability across the isolate. Result: DNA was amplified for ITS rDNA region at 650-700 bp in all the sixteen isolates. BLAST detection of nucleotide sequence of sixteen isolates framed mainly into two distinct phylogenetic clusters. Cluster B consisted of two isolates (MPSe 1 and MHSa 3) whereas, Cluster A contains the remaining fourteen isolates. There was a variation with respect to oxalic acid production among the isolates which was in the rage of 1.15 to 2.23 mg/ml.
Yüzyıllık Cumhuriyetimizde Tıp eğitiminin yolculuğu
Authors: ŞAHİN Hatice
Published: March 2024

Türkiye Cumhuriyeti’nin ilan edildiği 29 Ekim 1923 yılından bu yana yüz yıl geçti. Ne mutlu bizlere ki, Atatürk gibi ileri görüşlü bir lidere sahibiz. Cumhuriyetin kazanımları olarak adlandırılan devrimler içinde yükseköğretim ve tıp eğitimi alanında yapılan çalışmalar da yer almaktadır. Atatürk tarafından kültür / üniversite reformu olarak başlatılan çalışmalarda yüz yıllık sürede yaşanan olumlu-olumsuz değişimler bu yazıda özetlenecektir. Yazının amacı okuyucularımızı ülkemizin yükseköğretim-tıp eğitimi tarihi konusunda bir yolculuğa çıkarmak ve tıp eğitimi ile ilgilenen tüm tarafların gelecekte yapacakları çalışmalara ışık tutmaktır. Cumhuriyetimizin yaşında olan modern tıp eğitimimizin dünya çapında değerli hekimler yetiştirmesi ülkemizi muasır medeniyetler seviyesine çıkarmada anahtar özelliktedir. Daha nice yüz yıllara dileği ile iyi okumalar.
Electrochemical-induced hydrofunctionalizations of alkenes and alkynes
Authors: Zhang Yahui , Zhao Xiangyu , Qing Guangyan
Published: March 2024

The hydrofunctionalizations of readily available alkenes and alkynes are one of the most effective and useful routes to afford diverse value-added compounds. Although traditional hydrofunctionalization strategies catalyzed by metal catalysts present convenient approaches, they are also accompanied by resource consumption and environmental crisis. Electrosynthesis, as a renewable and sustainable technology, has become a cost- and atom-efficient and useful synthetic route. In this review, the electrochemical-induced hydrofunctionalizations of alkenes and alkynes are summarized and presented. In each section, the electrochemical synthetic strategy to access hydrogenation and other hydrofunctionalization (hydroboration, hydrosilylation, hydroalkylation, hydroalkoxylation, hydrocyanation, hydrocarboxylation, etc. ) products are elaborated in detail separately. Finally, the current challenges and prospects for electrochemical hydrofunctionalizations of unsaturated carbon‒carbon (C‒C) bonds are also discussed briefly.
FULFILLMENT OF INDICATORS AND ENHANCEMENT EXTRINSIC MOTIVATION OF STUDENTS THROUGH TEAMS GAMES TOURNAMENT IN GEOGRAPHY LEARNING
Authors: Operma Sukron , Wilis Ratna , Anas Fitri Yanti
Published: March 2024

The success of the learning process is the core goal of education. The success of the learning process can be seen from several things, one of which is student learning motivation. Learning motivation plays an important role in achieving learning success, and it has the potential to affect learning interest, activeness, and learning outcomes. The existence of strong learning motivation will catapult students to success in learning. Students' low motivation to learn is a concern for researchers to solve. This study aims to increase student motivation through learning team games tournament (TGT). The research method used in this study is Classroom Action Research (PTK) with a quantitative-descriptive approach. The data collection technique used is to distribute questionnaires that will be filled out by students. This research was conducted at SMAN 3 Padang on geography subjects. The results of this study show that teams games tournament (TGT) can meet extrinsic learning motivation indicators. The level of fulfillment of all indicators is more than 60% and even reached 72%, such a percentage is classified as "Enough" and "Good". Teams games tournaments (TGT) can also increase students' extrinsic learning motivation. The learning can increase the percentage of students with “Medium” and “High” motivation to 80%.
Penerapan Model Pembelajaran Berbasis Permainan Tradisional Engklek yang Dimodifikasi untuk Upaya Meningkatkan Motorik pada Anak Tunagrahita
Authors: Fary Ain fary , Rohman Ujang , Wiyarno Yoso , Utomo Maris Aka Satriyo
Published: March 2024

Abstrak. Penelitian ini termasuk jenis penelitian dan pengembangan atau (R&D). Penelitian (R&D) merupakan penelitian yang mengembangan suatu produk baru atau menyempurnakan produk yang telah ada sebelumnya, dengan desain one group pretest and posttest design permainan tradisional engklek yang dimodifikasi untuk meningkatkan kemampuan motorik pada anak tunagahita. Teknik pengumpulan data sebelum dan setelah melakukan aktivitas tanding kemudian diproses dan dianalisis menggunakan SPSS. Berdasarkan dari hasil analisis data, diskripsi, pengujian hasil penilitian, dan pembahasan, dapat diambil kesimpulan, yaitu upaya untuk meningkatkan gerak motorik pada anak tunagrahita dengan memodifikasi pemainan tradisional engklek yang dimodifikasi cukup memberikan pengaruh yang signifikan dan baik untuk perkembangan motorik pada anak tunagrahita di SDLB Putra Mandiri Surabaya. Sebagai bahan pertimbangan dalam menganalisis serta mengetahui gerak motorik pada anak tunagrahita dalam melakukan permainan tradisional engklek yang telah dimodifikasi, dengan harapkan anak tunagrahita mampu dan antusias melakukan permainan tradisioanal engklek untuk merangsang gerak motoriknya.
İngiliz Askeri Ataşe Raporlarında 31 Mart Vakası ve Hareket Ordusu’nun İstanbul Kuşatması
Authors: Ertekin Ferdi
Published: March 2024

İngiliz istihbaratının askeri konularda uzman personeli olan askeri ataşeler, İstanbul’daki İngiliz Sefareti’ne bağlı olarak 19. yüzyılın son çeyreğinden itibaren periyodik olarak raporlar hazırlanmıştır. Bu raporlardan 1909 senesine ait klasörde, yakın dönem Türk tarihi açısından hala gizemini koruyan son derece kritik iki olayın kayıtları mevcuttur. Bu makalede, Londra’daki The National Arvhives’da, Dışişleri Bakanlığı (Foreign Office) tasnifinde yer alan ve Türkçe literatürde ilk defa yayınlanan 1909 tarihli İngiliz askeri ataşe raporları üzerinden 31 Mart Vakası ve Hareket Ordusu’nun İstanbul kuşatması ele alınmaktadır. II. Meşrutiyet’in ilânından sonra anayasal düzen ve meşruti monarşinin muhafızı olarak İstanbul’a gönderilen ve 31 Mart Vakasını ateşleyen unsurlar arasında bulunan avcı taburlarının eylemleri, Hareket Ordusu’nun İstanbul kuşatması ve Payitaht’ın ele geçirilmesi Albay Herbert Conyers Surtees’in (1858-1933) raporlarında, oldukça canlı tasvirlerle ortaya konulmaktadır. Sultan II. Abdülhamid’in otuz üç yıllık saltanatını sona erdiren, Mahmud Şevket Paşa ile İttihat ve Terakki Cemiyeti’ni iktidarda söz sahibi hale getiren bu olayların raporlardaki ele alınış tarzından dönemin İngiliz persperktifine dair önemli ipuçları elde etmenin yanı sıra, her iki olay ile alakalı yeni bilgilere erişmek mümkündür.
Lightweight equivariant model for efficient interatomic potential
predictions
Authors: Shen Lei , Yang Ziduo , Wang Xian , Li Yifan , Lv Qiujie , Chen Calvin
Published: March 2024

In modern computational materials science, deep learning has shown the capability to predict interatomic potentials, thereby supporting and accelerating conventional simulations. However,
existing models typically sacrifice either accuracy or efficiency. Moreover, lightweight models are highly demanded for offering simulating systems on a considerably larger scale at reduced computational costs. Here, we introduce a lightweight equivariant interaction graph neural network (LEIGNN) that can enable accurate and efficient interatomic potential and force predictions for molecules and crystals. Rather than relying on higher-order representations, LEIGNN employs a scalar-vector dual representation to encode equivariant features. By extracting both local and global structures from vector representations and learning geometric symmetry information, our
model remains lightweight while ensuring prediction accuracy and robustness through the equivariance. Our results show that LEIGNN consistently outperforms the prediction performance of the representative baselines and achieves significant efficiency across diverse datasets, which include catalysts, molecules, and organic isomers. Finally, we conduct a comparative analysis of LEIGNN against both classical molecular dynamics (MD) and ab initio MD simulations across solid, liquid, and gas systems. It is found that LEIGNN can achieve the accuracy of ab initio MD and retain the computational efficiency of classical MD across all examined systems, demonstrating its accuracy, efficiency, and universality.
Chironomus Species Dna Barcording in Monitoring the Pollution Levels of the Nyanza Gulf in Lake Victoria, Kenya
Authors: Misiko Monicah Florence , Bere Taurai , Andika Darius O. , Okoth Patrick , Angienda Paul Oyieng , Onyango Benson
Published: March 2024

Chironomidae is a group of diptera insects, commonly known as “non-biting midges'' in the adult stage and “bloodworms” in the larval stage, represent a group of insects that thrive in various aquatic environment worldwide. Despite the plethora of information on Chironomidae in many parts of the world, there is a paucity of data regarding this indicator species in the polluted Kenyan Nyanza Gulf of Lake Victoria and molecular identification has not been explored. This study aimed to characterize Chironomidae species based on the mitochondrial DNA barcoding of the cytochrome oxidase subunit 1(COI) gene. Aquatic insects were collected from inshore and offshore in the Nyanza gulf, with a focus on pollution gradient. Chironomus larvae were subjected to analysis to discern divergence or convergence among conspecifics or intraspecific based on pollution gradients. The COI gene was amplified, sequenced using species-specific primers and compared to Gene Bank entries. Genetic analysis was done using MEGA version 11. Phylogenetic analyses employed Neighbor-joining and maximum parsimony algorithms with 1000 bootstrap replicates. The results revealed two known species, Chironomus transvaalensis from heavily polluted Kisumu station, and Chironomus pseudothummi from moderately polluted Kendu bay and Homabay stations, within the same biogeophysical environment. Additionally, a unique Chironomus species was identified on Ndere Island, an offshore station, presumed to be a clean site with restricted human activities. Sequences comparisons with global data indicated proximity but highlighted evolutionary significance and uniqueness. The study postulates that pollution serves as a selective pressure, driving the evolution of Chironomidae species in this particular region.
Assessment of Two SWCC Models for Predicting the Curve Fitting Parameters of Lateritic Soil – Bentonite Mixtures
Authors: Amadi A. A. , Isah D.
Published: March 2024

This study compares the capabilities of soil water characteristic curve (SWCC) models by Brooks-Corey (BC) and van Genuchten (vG) in estimating the curve fitting parameters for lateritic soil – bentonite mixtures. The SWCCs of soil treated with 0–10% bentonite and compacted with British standard light (BSL) energy at compaction states representing dry of optimum, optimum, and wet of optimum conditions were measured by sequential desorption using pressure plate extractor. The fitting parameters of the two equations were determined by a non-linear fitting program. The fitting capabilities of the models on the measured data were compared by statistical indices namely the root mean square error (RMSE), linearity (R2) and index of agreement (d). It was observed that the RMSE values ranged from 0.0035 to 0.0150 for vG model which are somewhat lower than the values for BC equation. Similarly, R2 for the vG equation (≥ 0.99) are, on average, slightly higher than those of the BC fits. However, the d values associated with the BC model which varied between 0.788 and 0.971 are higher than those of the vG (0.784–0.968). Overall, the study established that the vG model proved marginally superior in respect of goodness of fit.
IKKε-deficient macrophages impede cardiac repair after myocardial infarction by enhancing macrophage-myofibroblast transition
Authors: Ahn Youngkeun , Cho Hyang Hee , Rhee Siyeon , Cho Dong Im , Jun Ju Hee , Heo HyoJung , Cho Su Han , Kim Dohyup , Wang Mingqiang , Kang Bo Gyeong , Yoo Soo Ji , Cho Meeyoung , Lim Soo yeon , Cho Jae Yeong , Jeong In Seok , Kim Yong Sook
Published: March 2024

The regulatory role of the inhibitor of NF-kB kinase ε (IKKε) in post-myocardial infarction (MI) inflammation remains uncertain. Using an MI mouse model, we examined the cardiac outcomes of IKKε knockout (KO) mice versus wild type. We deployed single-cell RNA sequencing (scRNA-seq) and phosphorylated protein array techniques to profile cardiac macrophages. IKKε KO mice exhibited compromised survival, heightened inflammation, pronounced cardiac fibrosis, and reduced ejection fraction. A distinct cardiac macrophage subset in IKKε KO mice demonstrated increased fibrotic markers and decreased phosphorylated p38 (p-p38) levels, implicating an enhanced macrophage-myofibroblast transition (MMT) post-MI. While cardiac inflammation is crucial in initiating compensatory pathways, the timely resolution of inflammation was impaired in the IKKε KO group, while MMT in macrophages accelerated post-MI, leading to cardiac failure. Additionally, our study highlighted the potential of 5-azacytidine (5AZ), known for its anti-inflammatory and cardiac protective properties, in restoring p-p38 in stimulated macrophages. Administering 5AZ significantly reduced MMT in cardiac macrophages of the IKKε KO group. These findings underscore the regulation of inflammation response and macrophage transition by the IKKε-p38 axis, indicating MMT as a promising therapeutic target for ischemic heart disease.
Meteorological - Hydrological Coupling Flood Forecast and Error Propagation Characteristics Based on Radar Data Assimilation in Small- to Medium Sized River Basin：A Case Study of Zhanghe River Basin in China
Authors: Gao Yufang , cong linyi , Peng Tao , Sun Xin , Nie Tong , Hu Yigchun
Published: March 2024

In small- to medium-sized river basins, flood forecast accuracy and adequate lead times are especially important for the scheduling of catchment management decisions, involving flood prevention measures and disaster mitigation. For this study, the Zhanghe River basin in China was selected as the study area. A meteorological–hydrological coupled model, which linked the Weather Research and Forecasting (WRF) model to the WRF-Hydro model, was used with radar data to explore the influence of data assimilation frequency on rainfall and runoff forecasts, as well as the differences in error propagation characteristics between meteorological and hydrological models. The results were as follows: (1) Doppler radar data assimilation has the ability to improve the temporal and spatial variability of rainfall forecasts. Appropriate data assimilation show positive effect on improving the rainfall forecast. 3h assimilation intervals data assimilation may result in over-estimating under the influence of complex topography in Zhanghe River Basin. The rainfall forecast results based on 6 and 12 h assimilation intervals were more accurate than those derived from a 3 h interval, with the average cumulative rainfall errors being reduced by 44.86% and 53.26%, respectively. (2) Rainfall forecasts have a significant impact on the accuracy of subsequent runoff forecasts. The runoff results showed that the assimilation of radar data at higher frequencies does not guarantee the further improvement of the runoff simulations due to the overestimation of forecast rainfall. The average flood peak error under the 6 and 12 h assimilation intervals was 27.52% and 20.0%, respectively, less than that using the 3 h interval. Therefore, the effective information contained in the assimilation data is more important than the amount of data. (3) Error propagation between models differs with the changing assimilation frequency of the radar data and the consequent effect of the rainfall forecast. With the increase in assimilation frequency of the radar observations, the error range increases. Compared with the rainfall errors, the runoff errors show greater variability. Through quantitative analysis, it was found that there is no well-defined linear relationship between the rainfall and runoff errors. At the same time, the potential of radar data assimilation is discussed, and some suggestions for improvement are put forward.
Enhancing Bio-Based Concrete Mechanical Properties: A Novel Approach with Composite Sandwiches and Confined Cylinders
Authors: Bardouh Rafik , Homoro Omayma , Reboul Nadège , Saidi Mohammed , Amziane Sofiane
Published: March 2024

This paper addresses the growing use of bio-based materials in Europe, thanks to their low embodied energy and carbon sequestration. Despite favorable hygrothermal and acoustic properties, the inherent challenge lies in the low mechanical properties of biobased concrete. This study presents an innovative approach to strengthen hemp concrete through natural FRCM (Fabric Reinforced Cementitious Matrix), using two distinct reinforcement techniques. Firstly, a bending reinforcement consists of applying natural FRCM as the outer skins of a composite sandwich, with hemp concrete as the core. The effect of textile layers and pre-impregnation on the FRCM mechanical properties within the composite sandwich is evaluated. Secondly, compressive reinforcement entails confining hemp concrete specimens with FRCM. The results show a significant improvement in the mechanical properties of hemp concrete, with bending and compressive reinforcement leading to increases in the mechanical strength up to 17530% and 258%, respectively. Configurations involving mineral-impregnated fabric (PM FRCM) demonstrate superior mechanical reinforcement since it allows a better interphase bond between fabric and cementitious matrix. Different failure modes are observed between reference (non-reinforced) specimens and reinforced specimens, with bending reinforced specimens exhibiting shear failure and debonding at the interface of the composite sandwich, while reference specimens fail in bending. Moreover, compressive reinforced specimens undergo crushing of hemp concrete after tensioning rupture of the fabric, while reference specimens present angular shear path in the middle of the specimens. The results underscore the promise of FRCM in mechanically reinforcing biobased concrete, opening new opportunities for their expanded use in the construction industry.
Optimization and establishment of laboratory rearing conditions for Cimex lectularius L. against variable temperature and relative humidity
Authors: Banerjee Amartya , Saha Achintya , Das Parikshit , Kakati Ajay , Saha Buddhadeb , Goyary Danswrang , Bhutia Yangchen D. , Karmakar Sanjeev , Kishor Sumit , Rahaman Saidur , Chattopadhyay Pronobesh
Published: March 2024

Emerging infestations of bed bugs are affecting normal human lifestyles globally. To perform a scientific experiment, there is a paramount requirement for an established rearing condition. Thus, this study has been conducted to optimize and establish the rearing conditions for bud bugs (Cimex lectularius L.) based upon temperature and relative humidity. The bed bugs have been projected onto three temperatures (20 ºC, 25 ºC, and 30 ºC) and relative humidity (50%, 70%, and 90%) conditions to check their overall growth and survival rate. Adult mortality, weight loss, egg laying, percentage egg hatching, hatching initiation and completion, nymph mortality, and molting have been evaluated to optimize the best rearing conditions. The temperature at 25 ºC with 90% RH showed minimum mortality for adults (female 13.33±3.33% and male 6.67±3.33%) and nymphs (13.33±3.33%), maximum egg laying (40.33±1.86), and percentage hatching (98.23±0.58%). Moreover, at 30ºC with 90% RH, both hatching initiation and completion (5.19±0.12 days and 7.23±0.16 days) as well as molting initiation and completion (3.73±0.12 days and 7.00±0.24 days) were found to be fastest. Thus, it can be concluded that 25 °C with 90% RH is ideal for the rearing of adults, while 30 °C with 90% RH will be appropriate for their overall development.
IQOS point-of-sale marketing: a comparison between Arab and Jewish neighborhoods in Israel
Authors: Khayat Amal , Levine Hagai , Berg Carla J , Abroms Lorien C , Duan Zongshuan , Wang Yan , LoParco Cassidy R , Elbaz Daniel , Cui Yuxian , Bar-Zeev Yael
Published: March 2024

Background: Philip Morris International’s (PMI) IQOS, with its heatsticks (HEETS), is the heated tobacco product with the largest global market share. IQOS and/or electronic cigarettes use rate is higher among Arabs vs. Jews in Israel. This paper aims to compare IQOS point-of-sale (POS) marketing strategies, and regulatory compliance in Arab vs. Jewish neighborhoods in Israel.
Methods: We integrated data from two separate studies including a cross-sectional survey with IQOS retailers (December 2020-April 2021) and audits of POS that sold IQOS/HEETS (April 2021-July 2021) in 5 large cities in Israel, after marketing restrictions including a POS display ban and plain packaging became effective in Israel (January 2020). The survey included 69 POS (21 Arab, 48 Jewish neighborhoods) and the audits included 129 POS (48 Arab, 81 Jewish neighborhoods). Comparisons of IQOS marketing strategies between POS in Arab and Jewish neighborhoods were conducted using Chi-Square test, Fisher’s exact test or Mann-Whitney test, as appropriate. Thematic analysis was used to analyze open-ended questions.
Results:Most marketing strategies, such as promotions to customers, were uniform across POS in Arab and Jewish neighborhoods. The most noteworthy differences were that a higher proportion of retailers from Arab neighborhoods were invited to IQOS parties (47.6% vs. 21.7%, p<0.05) and reported personal communication with a PMI representative (80.0% vs. 51.2%, p<0.05). Additionally, PMI representatives assisted POS in both Arab and Jewish neighborhoods in implementing the display ban by providing free compliant cabinets and product placement instructions, and directly interacted with customers. POS in Arab neighborhoods were more compliant with the display ban (25.5% vs. 8.8%, p<0.05), but less compliant with plain packaging (62.5% vs. 79.3%, p<0.05).
Conclusions:There were not many notable differences in IQOS marketing across POS in Arab vs. Jewish neighborhoods, but PMI utilized marketing elements of cultural significance, especially for POS in Arab neighborhoods, such as more personal communication and invitation to social events. Continuous surveillance of tobacco POS marketing and legislation compliance is needed, with a special focus on demographic/location-based differences.