bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis penerapan layanan Sapa Pustakawan di Perpustakaan IAIN Kudus
Authors: Buwana Radiya Wira
Published: June 2021

Introduction. IAIN Kudus Library has a plan to implement Sapa Pustakawan service as part of an information retrieval service to support reference services in satisfying users’ the information needs.. This study examines the concept of the service that planned to  be applied at  IAIN Kudus Library.

Data Collection Methods. This paper used a descriptive qualitative approach by using interviews supporting by document studies.

Data Analysis. The data from the interviews with the head of the IAIN Kudus Library and librarians of IAIN Kudus Library about the Sapa Pustakawan services were analysed by involving related references and theories to obtain several concepts.

Results and Discussions. The results indicate that in order to implement Sapa Pustakawan, the library manager needs to pay attention to some aspects namely place, product, human resources (librarian), and promotion.

Conclusion. The study shows that Sapa Pustakawan  plays a signifincat role in helping users for reference services including  anti-plagiarism by implementing those aformentioned aspects.
Tinjauan sistematis tentang preservasi warisan musik
Authors: Pramudyo Gani Nur , Salim Tamara Adriani
Published: June 2021

Introduction. The awareness of musical heritage shows an effort of preservation that performed by composers, musicians, performers, archivists, conservators, local society, community archivists, and government.

Data Collection Methods. The paper used a systematic review method with a qualitative approach represented by  literature from Taylor & Francis database.

Data Analysis. A multi-stage exclusion process showed nine articles for further review. An analytical grid/chart was used to systematize the most relevant information of the selected articles. A tree illustration (including roots, trunk, and leaves) was used to represent the main idea of each article.

Results and Discussion. The raised awareness of the importance of preservation can be supported by creating the music projects, promoting music for tourism, and music repackaging. We categorize seveal aspects of preserving heritage music such as 1) understanding the integrity of the original trace and media, 2) combining prescriptive & descriptive documentation 3) musical repackaging method, and 4) using Art Glove device.

Conclusion. A synthesis of proposals was developed to illustrate the musical heritage preservation that represents ideas of selected articles that have been reviewed. In addition, this study also allows the researchers to identify gaps in the literature and research directions.
Pelayanan perpustakaan desa berbasis inklusi sosial di Perpustakaan Desa Jendela Dunia Kabupaten Kuningan Jawa Barat
Authors: Komariah Neneng , Saepudin Encang , Rukmana Evi Nursanti
Published: June 2021

Introduction. A village library is a public library that support rural community education activities. The village library should be transformed into a sosial inclusion-based library. The paper aims to explore  services and activities of Jendela Dunia Village Library based on sosial inclusion.

Data Collection Method. This paper used a qualitatative research method with a case study approach.

Data Analysis. The data collection techniques were conducted through interviews, observations, and library studies.

Results and Discussion. The Jendela Dunia Village Library has been run based on sosial inclusion considering aspects of collection development to support the needs of the community with a web-based digital library. Several activities have also been conducted such as organising training of computer, making handicrafts, arts, and gymnastics, organisings innovative KOBOK services, managing mobile reading bicycles, and supporting health literacy through Posyandu and Posbindu.

Conclusion. Jendela Dunia Village Library is a sosial inclusion-based library that is creatively managed and has the full support of the village leader. This  can be a model for other village libraries in utilizing the potential of the village. Jendela Dunia Village Library also  opens training sfor library managers outside the village.
Pengaruh algoritma filter bubble dan echo chamber terhadap perilaku penggunaan internet
Authors: Wulandari Virani , Rullyana Gema , Ardiansah Ardiansah
Published: June 2021

Introduction. This study aims to explore effects of bubble filter and echo chamber on information searching behaviour on the internet, how it affects the scope of the internet ecosystem and users, and what we can see from the behaviour.

Data Collection Method. The paper used a mixed-methods approach with surveys, online discussions, and literature research. Twenty respondents between 19-21 years old participated in this exploratory study.

Analysis Data. Data was obtained and calculations have automatically accumulated through Google Form. The user data analysis and discussion were conducted manually by considering aspects of rationality concerning the literature and previous research.

Results and Discussions. The analysis results obtained were bubble filter and echo chambers were proven to affect internet users both in positive and negative ways.

Conclusions. Bubble filter and echo chamber may have both positive and negative effects simultaneously, however, it depends on the user because the system has provided control features to reduce both features. Using internet wisely is also parts of the important aspect.
Esplorasi website Perpustakaan Universitas Harvard, Universitas Gadjah Mada dan Universitas Telkom
Authors: Ridlo Muhammad Rasyid , Zain Robi Yoswan , Ginting Yesika Anggreini Br , Saputri Yoandini
Published: June 2021

Introduction. This article evaluates library websites of world class universities in Indonesia from several aspects including features, responsibility, and speed. One library website overseas is explored as a reference: Harvard University.  

Data Collection Method. This is a literature study exploring features on library websites of Universitas Gadjah Mada (UGM) and Telkom University.

Data analysis. The study used Harvard University library website as a reference. The results were presented into tables to discuss library websites of UGM and Telkom University.

Results and Discussion. Harvard University library webiste has 21 features except gallery, UGM has 11 features and Telkom University has 12 features similar to Harvard University library webiste. Our result showed that Library website of UGM and Telkom University still need to be improved as required to be a world class university. All three websites has an adjustable display depending on devices in accessing websites. Those three websites were considered as responsive websites. Based on PageSpeed Insight, they showed good performance.

Conclusion.  Information on the websites are well-managed, informative, efficient, and accessible. Universities in Indonesia may use several overseas university library websites as a reference.
Peran Dinas Kearsipan dan Perpustakaan dalam preservasi dan komunikasi kebudayaan lokal Provinsi Jawa Tengah
Authors: Ganggi Roro Isyawati Permata , Dewi Athanasia Octaviani Puspita
Published: June 2021

Introduction. The purpose of this paper is to explore the role of The Office of Archive and Library in preservation and communication of local culture.

Data Collection Method. Using a case study, this paper involved the data collection by interviews, observations and literature review.

Data Analysis. The data were descriptively analysed by using thematic analysis.

Results and Discussion. The Office of Archive and Library has three roles in preservation and communication of local culture. They are: (1) as an information provider; (2) as a local cultural preservation agency; and (3) as a communicator of local cultural information. The role in preservation and communication of local culture arises because of the duties of the Office of Archive and Library Office in managing knowledge and efforts to fulfill the intellectual needs of the community.

Conclusion. Preservation and communication of local culture conducted by the Office of Archive and Library Office is a manifestation of the function of library. The role in the preservation and communication of local culture will continue to develop in accordance with the user needs.
Conversational Interaction and Second Language Development: Recasts, Responses and Red Herrings? Alison Mackey and Jennifer Philip, The Modern Language Journal (1998), pp. 339-356.
Authors: Yi Du
Published: June 2021

n/a
SCREENING ANTIBACTERIAL ACTIVITY OF VIETNAMESE PLANT EXTRACTS AGAINST HUMAN PATHOGENIC BACTERIA
Authors: NGO LONG HOANG , NGUYEN THI HAI YEN , TRAN VU KHAC , DOAN VU VAN , NGUYEN MINH VAN , BUI HIEU TRUNG
Published: June 2021

Objectives: Infectious diseases caused by bacteria are a leading cause of death worldwide. Hence, the objectives of the study are aimed to evaluate the antibacterial activity against five human pathogenic bacteria of methanolic extracts from 66 plants collected from Vietnam.

Methods: The broth microdilution method was used to determine the minimum inhibitory concentration (MIC) of methanol extracts of 66 plant species against five bacterial strains.

Results: In this study, all the plant extracts were active against at least one train with MIC values ranging from 24 to 2048 μg/mL. Twenty-five plant extracts were active against all three Gram-positive bacteria (Bacillus cereus, Bacillus subtilis, and Staphylococcus aureus). Of these, the extracts of Macaranga trichocarpa (Rchb. f. and Zoll.) Mull. Arg. (Euphorbiaceae), Calophyllum inophyllum L. (Clusiaceae) and Caryodaphnopsis baviensis (Lecomte) Airy Shaw (Lauraceae) exhibited the highest antibacterial activity (MIC =24–128 μg/mL), followed by extracts of Betula alnoides Buch.- Ham. e × . D. Don (Betulaceae), Acronychia pedunculata (L.) Miq. (Rutaceae), Croton alpinus A. Chev. ex Gagnep. (Euphorbiaceae) (MIC =64–256 μg/mL). Furthermore, the extract of Rhus chinensis Mill. (Anacardiaceae) and Annona reticulata L. (Annonaceae) exhibited potent antibacterial activity against the two Bacillus species (MIC =32–64 μg/mL).

Conclusion: Results of this study reveal that plant extracts from Vietnam have highly antibacterial activity against Gram-positive bacteria. These results suggest that Vietnamese plant extracts may be a rich source of antibacterial drugs.
DEVELOPMENT AND PERFORMANCE EVALUATION OF TUMOR TARGETING POTENTIAL OF FOLATE SPACER FUNCTIONALIZED SOLID LIPID NANOPARTICLES
Authors: SINGH SHIKHA , CHATURVEDI PRIYANKA , K JAIN SURENDRA
Published: June 2021

Purpose: The objective of the present investigation was to assess the tumor-targeting potential of ligand-spacer engineered solid lipid nanoparticles (SLN) as nanoscale drug delivery units for site-specific delivery of a model anticancer agent, paclitaxel (PTX). SLNs were engineered by direct and indirect conjugation of folic acid (FA) through different types of polyethylene glycols (PEGs) (MW: 1000, 4000) as spacers.

Methods: The synthesized nanoconjugates (SLNFA, SLN1FA, and SLN4FA) were characterized by Fourier transform infrared spectroscopy, nuclear magnetic resonance, and transmission electron microscopic studies. Nanoconjugates were evaluated for entrapment, in vitro drug release (under various pH conditions) and hemolytic studies. Cell uptake and cytotoxicity studies were performed on human malignant cell lines (MCF-7) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.

Results: This study explored the effect of PEG spacer length on the targeting potential of folate-conjugated SLN. PTX entrapment and in vitro drug release from nanoconjugates augmented, and hemolytic toxicity of nanoconjugates slashed with the molecular weight of PEGs. Further, nanoconjugates with PEG 4000 displayed highest tumor-targeting potential as compared to other spacer conjugated nanoconjugates due to optimized steric hindrance and receptor mediated endocytosis among other PEGs.

Conclusion: Engineering of the dendritic surface with targeting ligand such as FA can enhance the site-specific anticancer drug delivery. PEGylation of SLN can improve the circulation time of SLN in the body. This is a debut study reporting FA conjugation to the surface through four PEGs as spacer and optimized the spacer chain length for effective cancer targeting through SLN. This report as a whole is believed to shed new light on the role of spacer chain length in targeting potential of folate-anchored SLN.
A CLINICAL STUDY OF SIDDHA HERBAL PREPARATION – M V KASHAYAM FOR THE TREATMENT, CONTROL, AND MANAGEMENT OF COVID-19
Authors: SP MALARKANNAN , P DHARUMARAJAN , MK HARIYOHESH
Published: June 2021

Objective: At present, the pandemic COVID-19 by novel coronavirus causing severe mortality and losses to the human and no specific medicine to cure. Siddha is an ancient system of medicine used in using a variety of medicinal herbs to cure diseases of viral and unknown origin.

Method: The herbal medicine M V Kashayam prepared as per Siddha formula administered at the dose rate of 150 ml for every 6-h interval for Reverse Transcription–Polymerase Chain Reaction (RT – PCR) positive patients

Results: The prepared MV Kashayam can able to provide RT-PCR negative in 87.5% of cases within 4–6 days and 97.5% negatives in 12 days. The body temperature, Oxygen saturation level (SPO2), and respiration level become normal within 3 days.

Conclusion: The Siddha medicine, MV kashayam may be used as herbal medicine to treat the COVID-19 patients for earlier recovery and as a preventive measure to enhance immunity.
STATISTICS OF CANCER, 2020 IN INDIAN STATES: A REVIEW ON THE REPORT FROM NATIONAL CANCER REGISTRY PROGRAMME
Authors: BEGUM SHAIK ASHA , RANI S JOSHNA , BANU AHMADI , PAVANI AVULA , YERUVA VEENA
Published: June 2021

The deliberate assortment of information on cancer growth was performed by different populace-based disease vaults (population-based cancer registries [PBCRs]) and clinic-based cancer growth libraries (hospital-based cancer registries [HBCRs]) across India under the National Cancer Registry Program–National Center for Disease Informatics and Research of Indian Council of Medical Research since 1982. This survey analyzed the malignant growth occurrence, designs, patterns, projections, and mortality from 28 PBCRs and furthermore the stage at introduction and kind of therapy of patients with disease from 58 HBCRs (n=667,666) from the pooled investigation for the composite time frame 2012–2016. Time patterns in cancer growth rate were created as yearly percent change from 16 PBCRs (those with at least 10 years of consistent great information accessible) utilizing Joinpoint relapse. Aizawl locale (269.4) and Papumpare region (219.8) had the most elevated age changed occurrence rates among guys and females, separately. The extended number of patients with disease in India is 1,392,179 for the year 2020, and the basic five driving destinations are cancer, lung, mouth, cervix uteri, and tongue. Patterns in disease frequency rate showed an expansion on the whole locales of cancer in both genders and were high in Kamrup Metropolitan (yearly percent change, 3.8%; p<0.05). Most of the patients with cancer were analyzed at the privately progressed stage for cancer (57.0%), cervix uteri (60.0%), head and neck (66.6%), and stomach (50.8%) disease, while in cellular breakdown in the lungs, far off metastasis was dominating among guys (44.0%) and females (47.6%). This audit gives a system to surveying the status and patterns of cancer growth in India. It will manage proper help for activity to fortify endeavors to improve cancer growth avoidance and control to accomplish the public non-communicable illness targets and the reasonable advancement objectives.
Apuntes críticos al psiquismo de la violencia de Byung-Chul Han
Authors: Rodríguez Soriano Roberto Israel
Published: June 2021

A lo largo de su obra filosófica, Byung-Chul Han desarrolla la noción de sociedad de rendimiento como concepto interpretativo y explicativo de las configuraciones sociales y culturales actuales. Lo que caracterizaría a la sociedad tardomoderna es que los sujetos se encuentran saturados de sí mismos; trabajan jornadas exhaustivas para cumplir exigencias que se ponen a sí mismos como el ideario de la búsqueda y consecución de la realización de sus vidas. Esta dinámica ha implicado que el ejercicio de la violencia se interiorice, haciendo que ésta se ejerza sobre sí mismo. Para Han, ha habido una transformación en la constitución psíquica que ha posibilitado que el deber, que imponía el ideal del yo sobre el yo, que era negatividad y que representaba un ejercicio de violencia desde el exterior hacia el sujeto, se transforme en poder. Ahora, supone Han, el ideal del yo, como elemento psíquico que definía la negatividad, se ha diluido o se ha fusionado con el yo. El sujeto ahora “más bien se obedece a sí mismo”. Según su interpretación, el narcisismo sería lo que ahora definiría al sujeto de la sociedad del rendimiento. Sin embargo, la interpretación de Han sobre las implicaciones del deber y del poder en la relación del yo y del ideal del yo parece errónea a la luz de una relectura de la propuesta freudiana sobre la dialéctica y la tópica psíquica. En este trabajo se ofrecerán algunos argumentos para sostener esta tesis que pasan, en primer lugar, por la lectura de la hipótesis freudiana sobre las pulsiones sexuales y las pulsiones de muerte; en segundo lugar, por la relectura de la formulación freudiana de la tópica psíquica; y, finalmente, por la idea de autonomía kantiana que supone Han en su argumentación y por la referencia al uso y la finalidad del panóptico benthamiano.
Teología y pathos: Heschel y su filosofía de la divinidad
Authors: Sevilla Godínez Héctor
Published: June 2021

Entre las principales aportaciones de Heschel está la de considerar el pathos de Dios, es decir, la conexión entre Dios y el hombre, a partir de la afectación emocional entre ambos. Además, la noción de que el hombre no es quien debe buscar a Dios, sino que le corresponde aceptar una alianza con Él, constituye el punto de partida de diversas reflexiones teológicas. Heredero del pensamiento judío oriental por ser miembro de una familia jasídica, Heschel ofreció un eslabón entre el pensamiento eurocéntrico y el asiático, y de manera muy concreta, entre la filosofía occidental de origen helénico y las aportaciones del pensamiento hebreo. De inicio, el artículo aborda la convicción de Heschel en torno a un Dios sin representaciones, que no se encuentre reducido con imágenes o esculturas; desde luego, al no existir recursos materiales para la simbolización de lo divino, Heschel propuso la conexión con su pathos o su emocionalidad. Tal concepto, abordado en la segunda sección de este texto, constituye el elemento central de la teología del rabino polaco y es la fuente de las principales críticas a su pensamiento. Por último, se alude el tipo de vínculo que corresponde a la relación entre el hombre y a Dios. A diferencia de otros teólogos, para Heschel no es el hombre el que debe buscar a Dios, sino que es Él quien está en búsqueda del hombre, ya sea para reiterar su Pacto o para refrendar su presencia
Transformation of Public Administration in the Digital Era
Authors: Likhtin А. A.
Published: June 2021

The purpose of the article is to characterize the conditions for the transformation of pub- lic administration in the digital age. The relevance of the research is connected with the actively spreading digital innovations, which increasingly cover the frontiers of public ad- ministration, forming a new framework for institutional changes. These changes need competent reflection and systematization. The theoretical part of the work is devoted to the discussion of the concepts of “open government”, “digital government”, “digital trans- formation”, which have become one of the key elements of public management discourse. The process of digitalization involves the free flow of information from public authorities to the public and third parties, such as civil society organizations and the media, as well as from the public and third parties to the authorities, and is at the heart of well-function- ing open governments that are successfully undergoing the path of digital transformation. Methodologically, the article is based on expert interviews with representatives of public authorities of St. Petersburg, aimed at forming an idea of the institutional framework for the transformation of public administration in the context of digitalization. The author of the article conducted a number of expert interviews with the deputy heads of the districts of St. Petersburg and the deputy chairmen of the committees. As a method of interview analysis, the content analysis of the interview was used using the software ATLAS.ti 9 (http://atlasti.com). The main procedures implemented in this program are coding and grouping by category. As a result of the study, 16 codes were identified, which were com- bined into 3 semantic categories: macro-institutional conditions, micro-institutional condi- tions, and technical conditions for successful transformation of public administration in the context of digitalization. Analyzing the interview data, the author comes to the conclusion that the success of the transformation of public administration in the era of digitalization is directly related to the efforts and resources allocated by public sector bodies to imple- ment the law or policy, both at the time of implementation and over time. In other words, the interweaving of macroinstitutional, microinstitutional, and technical conditions plays a critical role. At the same time, the competencies of civil servants at all levels of govern- ment are a unifying element, a generative factor in the implementation of both macro-in- stitutional, micro-institutional, and technical conditions for the transformation of public administration in the era of digitalization.
An in-vitro study of Himalayan plant extracts against oomycetes disease Saprolegniasis in rainbow trout (Oncorhynchus mykiss)
Authors:   ICAR- Central Institute of Fisheries  Education, Mumbai-400 036, Tandel R.S. , Chadha N.K. ,   ICAR- Central Institute of Fisheries  Education, Mumbai-400 036, Dash P. ,   ICAR- Central Institute of Fisheries  Education, Mumbai-400 036, Sawant P.B. ,   ICAR- Central Institute of Fisheries  Education, Mumbai-400 036, Pandey N.N. ,   ICAR- Directorate of Coldwater  Fisheries Research, Nainital-263 136, India, Chandra S. ,   ICAR- Directorate of Coldwater  Fisheries Research, Nainital-263 136, India, Bhat R.A.H. ,   ICAR- Directorate of Coldwater  Fisheries Research, Nainital-263 136, India, Thakuaria D. ,   ICAR- Directorate of Coldwater  Fisheries Research, Nainital-263 136, India
Published: June 2021

Aim: This study aimed to investigate the effectiveness of ethanolic extract of three Himalayan plants Myrica esculenta, Thymus linearis and Butea monosperma on hyphal germination, colonisation and sporulation of two species of Saprolegnia (Saprolegnia parasitica and S. australis) isolated from rainbow trout, Oncorhynchus mykiss. Molecular docking of active ingredients of M. esculenta, Myricetin with effector proteins of S. parasitica was also performed to investigate the target binding sites for drug development. Methodology: Minimum inhibitory concentration (MIC), mycelium growth inhibition, spore germination, and inhibition was performed with the most effective concentrations. Molecular docking was carried out with AutoDock Vina software to investigate target binding sites with S. parasitica. Results: Extracts from Myrica esculenta, Thymus linearis and Butea monosperma showed MIC values of the 25, 100, 50 mg ml-1 against S. parasitica and 25, 50, 25 mg ml-1 against S. australis hyphal growth, respectively. Nevertheless, malachite green as reference control was effective with a MIC value of 2.5 mg l-1. The concentration required to inhibit S. parasitica and S. australis spores were (50) Myrica esculenta, (25) Thymus linearis, (100) Butea monosperma in mg ml-1 and (50) Myrica esculenta, (50) Thymus linearis, (100) Butea monosperma in mg ml-1, respectively. Interpretation: The study concludes that M. esculenta and B. monosperma are effective against Saprolegniasis and could be used as phyto additives.
OFICINA SOBRE VIOLÊNCIA CONTRA A MULHER NO ÂMBITO DO PROJETO MULHERES IFSP: UM RELATO DE ESCUTA
Authors: Santos Ana Carolina Vila Ramos
Published: June 2021

Este trabalho apresenta um relato de experiência de realização de uma oficina sobre violência contra a mulher (04 horas-aula) oferecida no projeto “Empoderamento Feminino através da geração de renda pelas vendas” desenvolvido no âmbito do Projeto Mulheres IFSP no campus São Paulo-Pirituba. A metodologia aplicada é a de oficina em dinâmica de grupo que adota como princípio a escuta qualificada e compartilhamento das experiências das discentes e assume como objetivo fomentar um espaço de acolhimento por meio do qual as participantes possam elaborar simbolicamente o tema e desenhar possibilidades de saída de situações de abuso por meio do apelo a mediadores institucionais e pela percepção de si mesma como pessoa cuja vida e dignidade precisam ser garantidas.
O “QUINTAIS DE MEL”: A CRIAÇÃO DE ABELHAS SEM FERRÃO COMO FERRAMENTA DE EDUCAÇÃO AMBIENTAL
Authors: Silva Tiago Amaral , Felippsen Eduardo Alberto , Mandotti Sônia Maria , Simão Daniel Ferreira , Gimenes Gabriela Martines
Published: June 2021

RESUMO: O “Quintais de Mel” é um projeto de extensão desenvolvido pelo Instituto Federal do Paraná em Assis Chateaubriand. O objetivo principal do projeto é promover a educação ambiental em escolas e comunidade em geral para então contribuir com a preservação das abelhas nativas sem ferrão. Para tanto, segue-se um percurso metodológico de quatro etapas no projeto. Primeiro a estruturação de um meliponário didático para manejo dos enxames das abelhas sem ferrão. Segundo, a promoção de ações educativas nas escolas do município de Assis Chateaubriand, como oficinas e palestras sobre a temática em questão. Terceira estimular a população atendida a criar abelhas nos próprios quintais de suas casas. A última etapa, trata-se da capacitação de pessoas interessadas na criação de abelhas sem ferrão e a produção de pasto meliponícola. Atualmente o projeto está com a maioria das atividades online, com a produção de conteúdos relacionados ao tema central, e os publica em redes sociais, assegurando as recomendações de isolamento social. Espera-se com o retorno de atividades presenciais no IFPR, que os estudantes das escolas atendidas pelo projeto, visitem o meliponário didático e tenham experiências com o manejo e cultura de preservação das abelhas nativas sem ferrão.  

Palavras-chave: Polinizadores. Conservação. Sustentabilidade.
Birch-naïve, oak-allergic subjects’ response to birch pollen in an environmental chamber
Authors: Ramirez Robert M. , Jacobs Robert , Andrews Charles P
Published: June 2021

BACKGROUND: Oak and birch pollens are known to have strong
cross-reactivity. It is unknown how robust this cross-reactivity is in
subjects without natural exposure to pollen of both trees. We aimed to
assess in an Allergen Challenge Chamber (ACC), the symptomatic
responsiveness to birch pollen in subjects allergic to and naturally
exposed to Virginia Live Oak (VLO) pollen and SPT-sensitive but not
naturally exposed to birch pollen. METHODS: Subjects underwent
SPT and blood draw for ssIgE to oak and birch antigens. Residential
historical data were obtained. Subjects were exposed to birch pollen
(3,500 ±700 gr/m ) in 2 consecutive 3-hour
challenges. Symptoms were recorded at baseline and 30-minute intervals.
RESULTS: Twenty-four subjects, 12 males, age 20-58 yrs,
completed the study. Sixteen subjects (66.7%) responded with high total
symptom scores (TSS) ≥10 of max 21. Twelve subjects (50%) had ssIgE
≥0.70 kU/L to oak. Subjects with a Class II ssIgE to oak pollen had a
significantly higher max TSS than those without. Fifteen subjects
without natural exposure to birch pollen responded with TSS equivalent
to 9 with previous natural exposure. Those without natural birch
exposure also responded similarly to subjects in birch endemic areas
reported in the literature. CONCLUSION: Subjects allergic to
oak pollen residing in South Texas, responded to birch pollen in an ACC
with symptoms comparable to both those with previous exposure and also
those residing in endemic areas and reported by other researchers. This
robust response of cross-reactivity in oak-allergic subjects, without
prior endemic exposure, suggests that a cross-reactive intervention
could be efficacious.
Whatever happens, two mammary is better than one
Authors: Bonalumi Giorgia , Giambuzzi Ilaria , Lorusso Roberto , Mauro Michele Di
Published: June 2021

It is well known that the left internal mammary artery (LIMA) should be
the first conduit of choice. Similarly, especially in patients younger
than 70 years, other conduits should be search among arterial grafts
such as right internal mammary artery (RIMA) or radial artery (RA). If
the RA can be harvested in the meanwhile of LIMA harvesting without time
consuming, it is well established that former one has to be grafted only
on presence of a good run-off. One of the main criticisms moved to the
use of RIMA are linked to technical difficulties in its harvesting it.
Edgar Aranda-Michel and coworkers tried to answer to the age-old
question is “RIMA has to be used in situ or free-graft?” In a
retrospective study on 667 patients (442 had free RIMA and 245 had free
RIMA) that were also matched through propensity analysis (202 patients
per group), they did not find any differences between the two groups in
the major outcomes, including heart failure specific readmissions. This
finding is consistent with the literature, hence the take-home message
is whatever happens, two mammary is better than one.
Mechanism studies on the cellular internalization of nanoparticles using computer simulations: A review
Authors: Feng Yun Hao , Chen Bo Zhi , Fei Wen Min , Cui Yong , ZHANG CAN YANG , Guo Xin Dong
Published: June 2021

Nanomaterial drug delivery systems have become one of the most important
targeted therapy technologies. Although great efforts have been made to
study the self-assembled mesoscopic structure of nanoparticles and
understand drug loading and release mechanisms, the interaction between
nanoparticles and cell membranes has not yet been clearly studied.
Moreover, the research of experimental methods in this field has been
greatly restricted due to its special time-space scale, so it is
necessary to apply computer simulations to visualize the cell
internalization of the nanoparticle. This review covers modelling
methods and the current status and viewpoints of research on the
influencing factors of the nanoparticle-biomembrane interaction
mechanism. In particular, we discussed in detail the positive and
negative effects of various nanoparticle properties. This article may
assist researchers in rationally optimize the nanoparticle structure to
improve therapeutic efficiency.
Belki żelbetowe wzmocnione płaszczem żelbetowym pod obciążeniem
Authors: Blikharskyy Zinoviy
Published: June 2021

W artykule przedstawiono badania eksperymentalne belek żelbetowych wzmocnionych płaszczem żelbetowym pod obciążeniem. Program badań eksperymentalnych belek żelbetowych obejmował analizę 4 serii o łącznej liczbie 16 belek, których długość wynosiła 2100 mm, z czego 14 wzmocnionych belek zostałowcześniej dodatkowo obciążonych. Wszystkie badane próbki zostały wzmocnione zbrojeniem podłużnym, które stanowiły pręty stalowe 2 ∅14 mm А500С. Belki wzmocniono płaszczem żelbetowym, którego zbrojenie stanowiły pręty zbrojeniowe 2 ∅10 mm А500С. Aby zasymulować rzeczywiste warunki eksploatacji, podczas wzmacniania belek zastosowano różne poziomy obciążenia, a mianowicie 30%, 50%, 70% i 90%,dla granicznej nośności niewzmocnionych belek. Na podstawie badań stwierdzono, że efekt wzmocnienia belek zmniejszył się z 92 do 76% w zależności od poziomu aktualnego obciążenia (30–90% nośności belek niewzmocnionych). Uzyskane wyniki badań eksperymentalnych mogą zostać uwzględnione w projektowaniu belek żelbetowych wzmocnionych płaszczem żelbetowym po ich wcześniejszym obciążeniu.
Causes and side effects of changing water quality in Khassa-Chai river in Kirkuk, Iraq
Authors: Qasim Abdulamir H.
Published: June 2021

Water quality of seasonal water rivers is on a quick decline due to various human activities arising as a result of urbanization and population growth. This study assessed the water quality of the Khassa-Chai river in Kirkuk during two seasons: winter and summer (wet and dry). Thirty-seven water samples were collected from eight monitoring observation points along the Khassa-Chai river during October 2019 and March 2020. Water samples were analyzed for various parameters such as temperature, pH, electrical conductivity (EC), turbidity, total suspended solids (TSS), total dissolved solids (TDS), color, and dissolved oxygen (DO). These physicochemical parameters were analyzed using standards methods demonstrated by the American Public Health Association (APHA). To determine the significant difference, all the results obtained were statistically analyzed. In most results, higher concentrations are out of the indicated permissible limits of the World Health Organization (WHO). It can be concluded that the most domestic wastewater effluents are discharged into the river, such as sewage coming from nearby houses and restaurants in addition to the solid waste produced from close commercial stores. To reduce the negative impact on water and human health, pollution sources need to be properly managed. The paper calls for further research to figure out the ability of the Khassa-Chai river to make the use of city water in improving the environment.
Deletion of the Feeding-Induced Hepatokine TSK Ameliorates the Melanocortin Obesity Syndrome
Authors: Wang Qiuyu , Zhang Peng , Cakir Isin , Mi Lin , Cone Roger D. , Lin Jiandie D.
Published: June 2021

Work in recent decades has established that metabolic hormones released by endocrine cells and diverse other cell types serve to regulate nutrient intake and energy homeostasis. Tsukushi (TSK) is a leucine-rich repeat-containing protein secreted primarily by the liver that exerts an inhibitory effect on brown fat sympathetic innervation and thermogenesis. Despite this, physiological regulation of TSK and the mechanisms underlying its effects on energy balance remain poorly understood. Here we show that hepatic expression and plasma concentrations of TSK are induced by feeding and regulated by melanocortin-4 receptor (MC4R) signaling. We generated TSK and MC4R–double-knockout mice to elucidate the nature of cross talk between TSK and the central regulatory circuit of energy balance. Remarkably, TSK inactivation restores energy balance, ameliorates hyperphagia, and improves metabolic health in MC4R-deficient mice. TSK ablation enhances thermogenic gene expression in brown fat, dampens obesity-association inflammation in the liver and adipose tissue, and protects MC4R-null mice from diet-induced nonalcoholic steatohepatitis. At the cellular level, TSK deficiency augments feeding-induced c-Fos expression in the paraventricular nucleus of the hypothalamus. These results illustrate physiological cross talk between TSK and the central regulatory circuit in maintaining energy balance and metabolic homeostasis.
High Out-of-pocket Health Care Cost Burden Among Medicare Beneficiaries With Diabetes, 1999–2017
Authors: Park Joohyun , Zhang Ping , Wang Yu , Zhou Xilin , Look Kevin A. , Bigman Elizabeth T.
Published: June 2021

OBJECTIVE

We examined the magnitude of and trends in the burden of out-of-pocket (OOP) costs among Medicare beneficiaries age 65 years or older with diabetes overall, by income level, by race/ethnicity, and compared with beneficiaries without diabetes.

RESEARCH DESIGN AND METHODS

Using data from the 1999−2017 Medicare Current Beneficiary Survey, we estimated average annual per capita OOP costs and percentage of beneficiaries experiencing high OOP burden, defined as OOP costs >10% or >20% of household income. We used joinpoint regression to examine the trends and generalized linear model and logistic regression for comparisons between beneficiaries with and without diabetes. Cost and income estimates were adjusted to 2017 USD.

RESULTS

Total OOP costs were $3,609–$5,283, with significant increases until 2005 followed by a leveling off. The prevalence of high OOP burden was 57%–72% at the 10% income threshold and 29%–41% at the 20% threshold, with significant increasing trends until 2003 followed by decreases. Total OOP costs were the highest in the ≥75% income quartile, whereas prevalence of high OOP burden was highest in the <25% and 25–50% income quartiles. Non-Hispanic Whites had the highest OOP costs and prevalence of high OOP burden. Beneficiaries with diabetes had significantly higher OOP costs ($498, P < 0.01) and were more likely to have high OOP burden than those without diabetes (odds ratios 1.32 and 1.25 at >10% and >20% thresholds, respectively, P < 0.01).

CONCLUSIONS

Over the past two decades, Medicare beneficiaries age 65 years or older with diabetes have faced substantial OOP burden, with large income-related disparities.
Efficacy and Safety of Dapagliflozin by Baseline Glycemic Status: A Prespecified Analysis From the DAPA-CKD Trial
Authors: Persson Frederik , Rossing Peter , Vart Priya , Chertow Glenn M. , Hou Fan Fan , Jongs Niels , McMurray John J.V. , Correa-Rotter Ricardo , Bajaj Harpreet S. , Stefansson Bergur V. , Toto Robert D. , Langkilde Anna Maria , Wheeler David C. , Heerspink Hiddo J.L.
Published: June 2021

OBJECTIVE

The Dapagliflozin and Prevention of Adverse outcomes in Chronic Kidney Disease (DAPA-CKD) study demonstrated risk reduction for kidney and cardiovascular outcomes with dapagliflozin versus placebo in participants with chronic kidney disease (CKD) with and without diabetes. We compared outcomes according to baseline glycemic status.

RESEARCH DESIGN AND METHODS

We enrolled participants with CKD, estimated glomerular filtration rate (eGFR) 25–75 mL/min/1.73 m2, and urinary albumin-to-creatinine ratio 200–5,000 mg/g. The primary composite end point was sustained eGFR decline ≥50%, end-stage kidney disease, or kidney or cardiovascular death.

RESULTS

Of 4,304 participants, 738 had normoglycemia, 660 had prediabetes, and 2,906 had type 2 diabetes. The effect of dapagliflozin on the primary outcome was consistent (P for interaction = 0.19) in normoglycemia (hazard ratio [HR] 0.62 [95% CI 0.39, 1.01]), prediabetes (HR 0.37 [0.21, 0.66]), and type 2 diabetes (HR 0.64 [0.52, 0.79]). We found no evidence for effect modification on any outcome. Adverse events were similar, with no major hypoglycemia or ketoacidosis in participants with normoglycemia or prediabetes.

CONCLUSIONS

Dapagliflozin safely reduced kidney and cardiovascular events independent of baseline glycemic status.
Advancing Therapy in Suboptimally Controlled Basal Insulin–Treated Type 2 Diabetes: Clinical Outcomes With iGlarLixi Versus Premix BIAsp 30 in the SoliMix Randomized Controlled Trial
Authors: Rosenstock Julio , Emral Rifat , Sauque-Reyna Leobardo , Mohan Viswanathan , Trescolí Carlos , Al Sifri Saud , Lalic Nebojsa , Alvarez Agustina , Picard Pascaline , Bonnemaire Mireille , Demil Nacima , McCrimmon Rory J.
Published: June 2021

OBJECTIVE

To directly compare the efficacy and safety of a fixed-ratio combination, of insulin glargine 100 units/mL and the glucagon-like peptide 1 receptor agonist lixisenatide (iGlarLixi), with those of a premix insulin analog, biphasic aspart insulin 30 (30% insulin aspart and 70% insulin aspart protamine) (BIAsp 30) as treatment advancement in type 2 diabetes suboptimally controlled on basal insulin plus oral antihyperglycemic drugs (OADs).

RESEARCH DESIGN AND METHODS

In SoliMix, a 26-week, open-label, multicenter study, adults with suboptimally controlled basal insulin–treated type 2 diabetes (HbA1c ≥7.5% and ≤10%) were randomized to once-daily iGlarLixi or twice-daily BIAsp 30. Primary efficacy end points were noninferiority in HbA1c reduction (margin 0.3%) or superiority in body weight change for iGlarLixi versus BIAsp 30.

RESULTS

Both primary efficacy end points were met: after 26 weeks, baseline HbA1c (8.6%) was reduced by 1.3% with iGlarLixi and 1.1% with BIAsp 30, meeting noninferiority (least squares [LS] mean difference −0.2% [97.5% CI −0.4, −0.1]; P < 0.001). iGlarLixi was also superior to BIAsp 30 for body weight change (LS mean difference −1.9 kg [95% CI −2.3, −1.4]) and percentage of participants achieving HbA1c <7% without weight gain and HbA1c <7% without weight gain and without hypoglycemia (all P < 0.001). iGlarLixi was also superior versus BIAsp 30 for HbA1c reduction (P < 0.001). Incidence and rates of American Diabetes Association level 1 and 2 hypoglycemia were lower with iGlarLixi versus BIAsp 30.

CONCLUSIONS

Once-daily iGlarLixi provided better glycemic control with weight benefit and less hypoglycemia than twice-daily premix BIAsp 30. iGlarLixi is a more efficacious, simpler, and well-tolerated alternative to premix BIAsp 30 in suboptimally controlled type 2 diabetes requiring treatment beyond basal insulin plus OAD therapy.

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Association of Psychobehavioral Variables With HOMA-IR and BMI Differs for Men and Women With Prediabetes in the PREVIEW Lifestyle Intervention
Authors: Adam Tanja C. , Drummen Mathijs , Macdonald Ian , Jalo Elli , Siig-Vestentoft Pia , Martinez J. Alfredo , Handjiev-Darlenska Teodora , Brand-Miller Jennie , Poppitt Sally , Stratton Gareth , Fogelholm Mikael , Pietiläinen Kirsi H. , Taylor Moira , Navas-Carretero Santiago , Winkens Bjorn , Handjiev Svetoslav , Muirhead Roslyn , Silvestre Marta , Swindell Nils , Huttunen-Lenz Maija , Schlicht Wolfgang , Lam Tony , Sundvall Jouko , Råman Laura , Feskens Edith , Larssen Thomas-Meinert , Tremblay Angelo , Raben Anne , Westerterp-Plantenga Margriet
Published: June 2021

Objective: Stress, sleep, eating behavior
and physical activity are associated with weight change and insulin resistance.
The aim of the analysis was the assessment of the overall and sex specific association
of psychobehavioral variables throughout the 3-y PREVIEW intervention using the
Homeostatic Model Assessment of Insulin resistance (HOMA-IR), BMI, and length of time in the study.

Methods:
Associations of psychobehavioral variables, including stress, mood, eating behavior physical activity (PA),
and sleep with BMI, HOMA-IR and time spent in study were assessed in 2184 participants
with pre-diabetes and overweight/ obesity (n=706 men; n=1478 women) during a 3-year
lifestyle intervention utilizing linear mixed modelling and general linear
modelling.The study was a randomized multicenter trial using a 2x2 diet-by- PA
design.

Results: Overall, cognitive restraint and PA
increased during the intervention compared to baseline, while BMI, HOMA-IR, disinhibition,
hunger and sleepiness decreased (all p<0.05). Cognitive restraint and PA were
negatively, while disinhibition, hunger, stress, total mood-disturbance were
positively associated with both BMI and HOMA-IR. Sleep-duration, low sleep
quality, total mood-disturbance, disinhibition and hunger scores were
positively associated with HOMA-IR for men only. Drop-outs at 6 months had
higher stress and total mood-disturbance scores at baseline and throughout
their time spent in the study compared to study completers.

Conclusion: Eating behavior and PA, control of stress, mood-disturbance and sleep characteristics were associated
with BMI, HOMA-IR and time spent in study with different effects in men and
women during the PREVIEW-lifestyle intervention-study.
Tailored use of compensation strategies to enable exercise despite festination in Parkinson's disease
Authors: E. A. Koelmans Berber , A. Verweij Niek , C. F. van de Weijers Sjors , R. Bloem Bastiaan , Nonnekes Jorik
Published: June 2021

Despite increasing evidence for, and heightened awareness of, the importance of exercise in Parkinson's disease, many patients remain sedentary. This tendency to lead an inactive lifestyle has various underlying reasons, including the presence of gait and balance impairments that complicate the patients' ability to perform sports activities. This case report illustrates that a personally tailored approach may be required in these patients, supported, if needed, by the use of compensation strategies or novel technological advances.
Evaluación de la germinación de Aniba perutilis Hemsl. (Comino crespo), procedente del municipio de San Carlos (Antioquia), para el establecimiento de fuentes semilleras
Authors: Álvarez Cubillos Jerson Javier , García Giraldo Brayan Camilo , López Quintero Alexander , Peña Guzmán Daniela
Published: June 2021

Este proyecto se desarrolló con el fin de evaluar el potencial de germinación de las semillas de Aniba perutilis (LAURACEAE), procedentes de 3 veredas del municipio de San Carlos (Ant.). El estudio se realizó entre noviembre de 2018 y febrero de 2019, en el vivero municipal del casco urbano de San Carlos; usando un sistema de siembra de cama sobre nivel del suelo, bajo un modelo completamente al azar en donde los tratamientos a analizar correspondieron a cada uno de los árboles fuente de semilla y repeticiones de 20 semillas por cada árbol. De cada zona caracterizada se seleccionaron tres árboles, de los cuales se obtuvo la semilla para los ensayos. Se valoró el porcentaje de germinación (G%) y porcentaje de mortalidad (M%). Finalmente se determinó que las mejores progenies proceden de las dos zonas con mejores condiciones de conservación, permitiendo localizar parches de bosque como posible fuente semillera.
Dataa näkyvissä: Läpinäkyvyys algoritmien ja datan journalistisessa hyödyntämisessä
Authors: Rydenfelt Henrik , Haapanen Lauri , Lehtiniemi Tuukka
Published: June 2021

Läpinäkyvyyden käsite on noussut keskeiseksi viestinnän, median ja politiikan tutkimuksessa sekä viestinnän ja politiikan käytäntöjen eettisessä arvioinnissa. Läpinäkyvyyttä on esitetty keinoksi ylläpitää ja kasvattaa luottamusta journalistista työtä ja sen tuotteita kohtaan interaktiivisessa media- ja viestintäympäristössä. Tiedontuotannon ja päätöksenteon perustuessa yhä enemmän dataan ja sen prosessointiin läpinäkyvyys on noussut keskeiseksi käsitteeksi myös algoritmisen päätöksenteon kohdalla. Tässä artikkelissa tarkastelemme läpinäkyvyyden roolia dataa ja algoritmeja sekä journalismia koskevassa keskustelussa ja esitämme mahdollisuuksia dataan ja algoritmeihin tukeutuvan journalismin läpinäkyvyyskäytännöiksi. Dataa hyödynnetään digitaalisessa journalismissa sekä informaation lähteenä manuaalisissa ja automatisoiduissa tuotantoprosesseissa että sisällön jakelussa ja kohdentamisessa yleisöille. Miten journalismi voisi tuoda läpinäkyväksi datan käyttöä, dataa koskevia valintoja ja niihin vaikuttavia tarpeita, tarkoituksia ja arvoja?
Kirja-arvostelut alustataloudessa – esimerkkinä käyttäjälähtöiset arvostelut Instagramissa
Authors: Jaakkola Maarit , Räisä Tiina
Published: June 2021

Kulttuurituotteita eivät sosiaalisen median aikakaudella enää arvostele julkisesti vain perinteisen median ammattikriitikot, vaan myös tavalliset ihmiset osallistuvat teosten julkiseen arvottamiseen erilaisilla digitaalisilla alustoilla. Tarkastelemme tässä artikkelissa kirjallisuusarvosteluja osana alustoitunutta kulttuurituotantoa esimerkkinämme käyttäjälähtöiset kirja-arvostelut erityisesti kuvasovellus Instagramissa. Instagramiin on vakiintunut kirjallisuuskeskusteluyhteisö, jota kutsutaan maailmanlaajuisesti nimellä Bookstagram mutta jolla on myös paikallisia tai alueellisia muotoja, kuten suomalainen Kirjagram. Kysymme, miten käyttäjäarvostelijat esiintyvät niissä arvostelulle määritellyissä funktionaalisissa rooleissa, jotka on aiemmassa tutkimuksessa havaittu perinteisten kriitikoiden toiminnassa. Erilaisten asemoitumisten perusteella hahmottelemme eroa kulttuurisen intermediaation ja kulttuurisen intramediaation käsitteiden välillä, joiden väitämme keskeisimmin kuvaavan eroa institutionaalisen ja käyttäjälähtöisen kirja-arvostelun välillä sekä samalla kuvaavan alustoituneen kirjallisuusarvostelun erityislaatuisuutta.