bluuebunny/crossref_metadata_2025 huggingface dataset:
The electroencephalografic creativity characteristics dependance on age and gender
Authors: Sapina Ye. A. , Kondratenko A. V. , Mernaya Ye. M. , Nikinova A. V. , Bazanova O. M.
Published: June 2020

It is important to define the creativity psychophysiologic traits and their modification possibility for biofeedback creativity training. It was shown earlier that creativity is connected with alpha-rhythm indices (individual alpha-peak frequency, individual alpha band width, spindle span time and variability). This study aim was to explore psychophysiologic creativity indicators modification possibility. For this purpose age and gender factors influence on creativity indicators and electroencephalographic alpha activity indices were studied. The creativity was measured with Torrance Test then encephalogram was recorded. It was shown that individual alpha activity indices and nonverbal creativity level increase simultaneously with age. Total Torrance coefficient depends on individual alpha band width in males and alpha amplitude variability in females. Fluency correlates positively with individual alpha peak frequency in males and negatively with individual alpha activity suppression in females. Flexibility and Originality depend on individual alpha band width in both gender groups and may be possibly modified with biofeedback training.
Typologization of the profiles of individual dynamics of self-regulation using the computer game biofeedback technology
Authors: Mazhirina K. G. , Jafarova O. A. , Freze V. R.
Published: June 2020

In this paper we present typologization of the profiles of individual dynamics of conscious self-regulation of human involuntary functions using the computer game biofeedback technology. To test the developed typologization the experiment was conducted in three different groups of subjects. The results of the study describe the individual characteristics of the subjects with different profiles of the dynamics of self-regulation, which are: differences in the level of tolerance to ambiguity; level of intellectual plasticity; characteristics of coping strategies. Besides, the stability of the typologization of the profiles of self-regulation was confirmed.
The role of brain dopaminergic system in forming of EEG biofeedback sessions effects
Authors: Fokina Yu. O. , Kulichenko A. M. , Pavlenko V. B.
Published: June 2020

It was shown on awake cats that activity of dopaminergic neurons of the ventral tegmentum was significantly increased during EEG biofeedback sessions directed on increasing of occipital area alpha- and teta-rhythms spectral powers (SP) relation or sessions wich were directed on increasing of frontal area beta- and teta-rhythms SP relation.
Analysis of spatio-temporal structure of EEG-activity to form an objective assessment of the individual characteristics of the sleep-wake behavior
Authors: Putilov A. A. , Donskaya O. G. , Veryovkin Ye. G. , Putilov D. A.
Published: June 2020

The structure of individual variation in waking EEG was elaborated in 130 sleep deprived subjects. Its quantitative relationship with chronotype (morning and evening lateness), somnotype (daytime and anytime sleepability) and trototype (daytime and anytime wakeability) was described. The findings indicate that individual vulnerability of wakeability to sleep loss can serve as a quantitative predictor using the structures of waking EEG at daytime and during sleep deprivation.
The increase of the effectiveness of complex treatment of ambliopia in children using the multichannel complex «BOSLAB-Zrenije»
Authors: Rybachuk Ye. V. , Voloshchuk T. I.
Published: June 2020

The paper demonstrates high effectiveness of treatment of ambliopia based on the electro-encephalographic training on the alpha-rhythm amplitude combined with traditional functional treatment methods. The results of the use of the multichannel complex Boslab-Zrenije in treatment of strabismus (heterotropia), various types of astigmatism, far-sightedness, anisometropia, binocular eyesight disorders, and nystagmus are discussed. The method appeared to be specially effective in treatment of ambliopia, complicated by impaired (non-foveolar) fixation.
The use of multiparametrer biofeedback to a patient with consequences of craniocerebral injury
Authors: Tsirkin G. M. , Nechayev Ye. V. , Nechayeva Ye. N.
Published: June 2020

The paper describes the clinical effects of the 9-months course of biofeedback-based treatment of a patient with tetraparesis. As a result of treatment a significant improvement of the conditions was registered.
Investigation of alpha-wave frequency characteristics in the patients with chronic tension headache and its modification during electromyographic-temperature training
Authors: Shubina O. S. , Melnikov M. Ye. , Veretelnikov I. A.
Published: June 2020

Chronic tension headache is the most commonly experienced headache. Low effectiveness of its treatment is connected with lack of understanding of this disorder pathogenensis. It was shown that electromyographic-temperature training provoked modification of alpha-wave power and frequency: power of alpha increased, frequency of maximal increased as well.
Using of the biofeedback in rehabilitation of patients with mercury intoxication
Authors: Diyakovich M. P. , Kazakova P. V. , Katamanova Ye. V. , Rusanova D. V.
Published: June 2020

The study results of using the biological reverse connection training with the musical therapy in the rehabilitation of the patients with the chronic mercury intoxication are represented in this paper. The positive effect of the BRC-training on processes concentration of retention, some subscales of the life quality, the functional state of the central afferent conducting structures as well as the neurophysiologic balance of the bioelectrical brain activity have been indicated.
Analysis of the vegetative status disoders of acyclic sportsmen and its correction with the technology of gaming biofeedback and transcranial electrostimulation
Authors: Guvakova I. V. , Kuznetsova L. A.
Published: June 2020

Examining 37 sportsmen with the predominant activity of sympathetic unit of the vegetative nervous system, we detected the switch of bloodstream regulation control to the higher vegetative centers. We showed the effectiveness of the transcranial electrostimulation and gaming biofeedback methods for complex correction of vegetative status disorders.
The dynamic of human EEG alpha-activity in the loop of brain — computer interface during trigger photo stimulation
Authors: Kaplan A. Ya. , Zhigalov A. Yu.
Published: June 2020

Trigger photo stimulation (TPS), based on synchronization of flashes of light with events in a brain, for example, with waves of alpha activity EEG, is widely known as a methodical approach for studying of mechanisms of a brain and also as a method of neurologic diagnostics. In the present work TPS has been used for the first time as an element of the brain — computer interface (BCI) where the start of light flashes determined by crossing of definite level by amplitude of EEG alpha-waves. It has been shown that specific reorganizations of alpha-waves time distribution during BCI-training. It testifies that brain develops a new control path by means of EEG alpha-patterns.
Brain bioelectricity activity of the sportsmen underwent the neurobiofeedback course
Authors: Styopochkina S. P. , Cherapkina L. P. , Tristan V. G.
Published: June 2020

The EEG analysis of the 26 highly qualified sportsmen shows, that the brain bioelectricity activity is changed by the neurobiofeedback. It relates with the alpha-rhythm and with the greatest neurodynamic changings in the right hemisphere. The after training EEG changings have the sex differences. Everything fields of the right hemisphere and the temporal-occipital field of the left hemisphere of the sportsmen-male and the forward-temporal of left hemisphere and the central-occipital field of both hemispheres of the sportswomen work during the neurodynamic changing.
Biofeedback in psychomotor training. Two month course results
Authors: Mernaya Ye. M. , Kondratenko A. V. , Kondratenko O. , Bazanova O. M.
Published: June 2020

With the aim to compare the impact of usual training and training with the use of biofeedback, the psychometric and electrophysiological features of 36 musical students were investigated. Two month biofeedback training caused increase in self actualization, improving the musical performance score, decrease state and trait anxiety, increase of the individual adjusted alpha-2 indices, but theta-, alpha-1 and beta- activities did not change. Optimal psychomotor reaction for usual self practice (enhancement in alphaactivity and decrease in muscle tension) was achieved during biofeedback training. Training efficiency depended on the baseline electropsysiological features of optimal functioning: peak frequency, band width, power and coherence in individual alpha range, reaction activation. It was concluded that upper alpha stimulating and EMG decreasing biofeedback training leads to development of optimal psychomotor behavioral strategy.
Method of drainage of retroperitoneal fat at infected pancreatonecrosis
Authors: Merzlikin N. N. , Kuznetsov A. V. , Barabash V. I. , Sorokin R. V.
Published: June 2020

The aim of this study was to improve the results of treatment of patients with infected pancreatonecrosis complicated with phlegmon of retroperitoneal fat. Toward this end, the following tasks were formulated: to develop a new way of drainage of the retroperitoneal fat at infected pancreatonecrosis — retroperitoneostomy and to analyze comparatively the efficiency of traditional methods of drainage of the pancreatic gland zone at infected pancreatonecrosis (omnetobursotomy, lumbostomy) with retroperitoneostomy.

The analysis was based on the results of examination and treatment of 60 patients with pancreatonecrosis complicated with phlegmon of retroperitoneal fat, who were operated in surgical departments of the Tomsk municipal hospital no. 3 in 2004—2008.

The use of retroperitoneostomy in the treatment of infected pancreatonecrosis complicated with phlegmon of retroperitoneal fat decreased postsurgical complications from 36.6 to 15.79% and lethality from 56.1 to 21,0%.
Application broncho-phonography investigation for an estimation of respiratory frustration at immature infants with a respiratory distress-syndrome
Authors: Pavlinova Ye. B. , Oksenchuk T. B. , Krivtsova L. A.
Published: June 2020

Respiratory distress syndrome of the newborn is a basic pathobiology immature infants and this grave condition of early neonatal period often is the cause of chronic lung disease — bronchopulmonary dysplasia (BPD). BPD is marked by hyperreactivity of bronchi. The growth of this pathobiology in view of survival of immature infant is increasing in recent years. To measure functional status of respiratory tracts of infants with classical methods (spirography) is impossible. But there is a new method of diagnostics of broncho-obstructive syndrome, it is broncho-phonography. This method is noninvasive and can be used without active patient’s part in investigation. The examination results of immature infants with respiratory distress syndrome and with bronchopulmonary dysplasia (BPD) with the help of broncho-phonography method are described in the article.

The results of respiratory patterns of immature infants are normal in spite of their disease. That’s why we can speak about usage of broncho-phonography method in differential diagnostics of wheezing and restrictive dysplasia.
The ways of optimization of medicine supply in conditions of CATR Zelenogorsk
Authors: Barankina T. A. , Yakimenko O. N. , Dmitruk S. Ye.
Published: June 2020

For the purpose of optimization of medicine supply of the population and disease-prevention institutions in conditions of closed administrative-territorial regions (CATR), we have studied one of the optimization trends — the efficiency of retail network of CATR using dynamic lines indices. On the base of the conducted consumers’ segmentation by solvency criterion we have worked out the recommendations on the structure optimization of chemist’s network of CATR in Zelenogorsk.
Medical budgeting at treatment sick Helicobacter-associations the chronic gastritis at stationary and out-patient-polyclinic stages
Authors: Sosnovskaya Ye. V. , Nikolayev N. A.
Published: June 2020

On the basis of the retrospective stratified research of 307 patients (143 men and 164 women) with the verified chronic gastritis, association with helicobacter pylori, lead on the basis of 6 municipal establishments of Omsk treatment of the given category of patients is established, that at equal efficiency of out-patient-polyclinic and stationary forms of rendering of medical aid by clinical criterion, from a position of budgeting, it is the most expedient in conditions of out-patient-polyclinic supervision.
Organizational aspects of rehabilitative care for patients with traumatic disease of the spinal cord
Authors: Khaibullina Z. R.
Published: June 2020

Proposed organizational aspects of rehabilitative care for patients with traumatic disease of the spinal cord. Aim was to study the organization providing rehabilitation of spinal patients. Identified the following stages of rehabilitation services: a full-fledged conservative therapy, rehabilitation, improvement or compensation for lost functions, the restoration of household activity, the restoration of social activity. Properly set the organization of rehabilitation services, allows patients to our clinic undergo a complete rehabilitation, which greatly improved the results of treatment of this severe pathology.
Overcoming methodological problems in biomechanics of respiration
Authors: Tetenev F. F. , Tetenev K. F.
Published: June 2020

The article represents the main scientific school of the Chair of Internal Diseases Propedeutics of the Siberian State Medical University (Tomsk) in the form of the review of the Chair employees’ works published since 1963.
Impact of body loss weight-oriented psychotherapy on indices of depression and anxiety in group of patients with overweight and obesity
Authors: Balashov P. P. , Tyutev R. A. , Muzyra A. Yu.
Published: June 2020

Purpose of this research is to value impact of body loss weight-oriented psychotherapy on indices of depression and anxiety. We used weight, body mass index, CES-D depression scale and Spielberger—Hanin anxiety scale before and one month after body loss weight — oriented psychotherapy group of 30 overweight patients. We have found significant body loss weight and improvement of scales results during 1 month period.
Chelating agents action on rat prostate
Authors: Yeschenko Yu. V. , Novitsky V. V. , Bovt V. D. , Yeschenko V. A. , Urazova O. I.
Published: June 2020

It was shown in experiments on rats, that dithizone induced zinc deficiency in prostate cells. Three phase type of fluctuations of cytochemically detected zinc concentration was observed in the cells: phase of primary decrease, phase of temporary partial restoration and the phase of secondary decrease. Sodium diethyldithiocarbamate unlike to dithizone didn’t induce damage of cells and secondary decrease zinc content in its.
Action of inhibitors Heat shock proteins 90 and 27 on dexamethasone-induced apoptosis of tumor cells
Authors: Kaigorodova Ye. V. , Ryazantseva N. V. , Novitsky V. V. , Maroshkina A. N. , Belkina M. V. , Chechina O. Ye. , Zima A. P.
Published: June 2020

Programmed cell death of tumor cells of line Jurkat in conditions of cultivation with various concentration of dexamethasone, selective inhibitors of Hsp90 (Heat shock protein — Hsp) (17-AAG) and Hsp27 (KRIBB3) was investigated. An estimation of realisation apoptosis spent by method of fluorescent microscopy with use annexin V-FITC and propidium iodide. Inhibition of Hsp90 and Hsp27 leads to activation of tumor cells Jurkat apoptotic program and strengthening of dexamethasone-induced apoptosis. Hsp27 and Hsр90 play an antiapoptotic role in tumor cells of line Jurkat.
Multisystem atrophy: clinical manifestations, pathogenesis questions
Authors: Valikova T. A. , Pugachenko N. V. , Korolyova Ye. S.
Published: June 2020

The article examines the pathogenesis and clinical features of multisystem atrophy. We present clinical and diagnostic criteria of the disease. The clinical signs of multisystem atrophy patients treated at the Neurological clinic Siberian State Medical University (Tomsk). The clinical case was examined.
Medical rehabilitation of persons in a chronic emotional stress
Authors: Zaitsev A. A. , Barabash L. V. , Levitsky Ye. F.
Published: June 2020

The research problem wasstudying of influence of a complex physicaland balneal therapies on endokrinno-metabolic processes and immune system of an organismof participants of confrontations with different forms of chronic diseases for the purpose of working out of adequate schemes of regenerativetreatment. 173 police officers, at the age from 22 till 45 years old which were taking part in military operations in the Chechen republicare surveyed. At receiptin a hospital for patients diagnosed following forms of chronic diseases: a chronic prostatitis, chronic холецистити neurologicdisplays of an osteochondrosis. Schemes of stageby-stage rehabilitation have been developed for correction of the revealed infringementswith appointment of base complexes at the first stage of regenerative treatment. On the basis of studying of dynamics of indicators of the endokrinno-metabolic status and a condition of immune system of an organism of participants of confrontations with various forms of chronic diseases the substantiation of the new approach to correction of the poststressful frustration, consisting in stage-by-stage rehabilitation with appointment at the first stage корригирующего a base complex is presented. The carried outcomparative analysis of efficiency of medical actionsspecifies in expediency of application двухэтапного a rehabilitation course (taking into accountconcrete nosological form) for correction of poststressful frustration at participants of operations.
Aspects of clinical differential diagnosis of radiculopathy in Lyme disease and spondylosis
Authors: Baranova N. S. , Nizovtseva L. A. , Spirin N. N. , Shipova Ye. G. , Bulanova V. A. , Krotova N. Yu.
Published: June 2020

The goal of the present study was to determine significant diagnostic signs of radiculopathy in the late stage of Lyme disease (LD) and in spondylosis. The pain in patients with radiculopathy and LD was often localized in the place of tick-bite (in 25.5%). The insidious onset of the disease was more typical in LD (in 84.3%), in patients with spondylosis and radiculopathy remissions and exacerbations were typical (62.2%). Inflammatory syndrome, polysystemic changes were typical for LD. In LD the effect of NAIDs was rather poor, the patients improved after treatment with antibiotics.
New therapy prediction technologies in multiple sclerosis
Authors: Golovkin V. I. , Pozdnyakov A. V. , Kamynin Yu. F. , Martens I. S.
Published: June 2020

The study investigates the intravital high-field proton magnetic resonance spectroscopy and superimposed magnetic scanning of brain metabolism in 60 patients showing the association between demyelination activity and the inflammatory or degenerative stage of MS. It also educes Flicker noise phenomenon as a new indicator of a pathologic process progression. The data on the tissue respiration decrease, of the neurotransmitter hypometabolism, energy, and enzyme brain systems were collected to use as the therapy prediction and monitoring of MS.
Prospects of laboratory risk evaluation of multiple sclerosis relapse and progressing
Authors: Smagina I. V. , Yelchaninova S. A. , Popovtseva A. V. , Ignatova Yu. N. , Gridina A. O. , Fedyanin A. S.
Published: June 2020

The Relapsing-Remitting Multiple Sclerosis (MS) patients research has revealed that the matrix metalloproteinase-2 level in cerebrospinal fluid which is higher then 30 ng/ml during the relapse and/or remission period increases repeated relapse risk during 2 years term by 2.8 times. The rapid MS progressing is associated with the high level of adhesion molecule (sPECAM) in cerebrospinal fluid.
Effectiveness of Copaxone in patients with relapsing-remitting multiple sclerosis
Authors: Alifirova V. M. , Titova M. A. , Vereschaka A. A.
Published: June 2020

We investigated the effectiveness of Copaxone in patients with relapsing-remitting multiple sclerosis for 3 and 5 years. Significant improvement found the decrease of the frequency of clinical exacerbations and delay the accumulation of physical disability during treatment period.
Clinical-laboratory and instrument indices of the thyroid gland state after surgical treatment of tumors of the chiasmatic-cellar region
Authors: Kan Ya. A. , Zhestikova M. G. , Bryzgalina S. M. , Shakhvorost N. P.
Published: June 2020

Hypopituitarism is often developed in the result of operative treatment of tumours in chiasmal-cellular area. One of frequent indications of hypophysis’ deficit is decreasing of product of thyroid-stimulating hormone (TSH) that leads to deficit of thyroid hormones. Most patients, who had been operated in terms of tumours of chiasmal-cellular area, have normal volume and structure of thyroid gland in the background of decreased level of free thyroxine and absence of increasing of level of TSH on the principle of feedback, it indicates to the secondary character of destruction of thyroid gland. Patients operated in terms of craniopharyngioma and somatoprolactinoma more often have secondary hypothyroidism. A high per cent of fibrotic changes of tissue of thyroid gland in patients operated in terms of prolactinoma is explain by autoimmune thyroiditis in anamnesis.
Lymphatic drainage of the brain in extreme arterial hypertension
Authors: Pesin Ya. M. , Borodin Yu. I. , Beiseembayev A. A. , Omorov N. K.
Published: June 2020

In the experiment on rabbits were presents, that experimental arterial hypertension didn’t led to functional failure of lymphatic drainage of brain. On the background of beta-blocker obzidan use failure liquor outflow from brain took place.
Food allergy prevalence in children of opisthorchiasis world region
Authors: Fyodorova O. S.
Published: June 2020

The study of the food allergy prevalence in children of Tomsk city and rural areas with high and low opisthorchiasis level was performed. It was revealed that the food allergy prevalence in children is associated with chronic opisthorchiasis level.
The main features of epidemiology and clinical-immunological interactions of infections caused by herpes viruses and opisthorchiasis at residents of Tomsk
Authors: Cherevko N. A. , Ogorodova L. M. , Vasiliyeva M. V.
Published: June 2020

To elucidate the epidemiological, clinical and immunological characteristics of infections caused by herpes viruses and opistorhisami in the etiology and pathogenesis of allergic diseases, we examined 350 residents of Tomsk. The high frequency of infection among residents of Tomsk with herpes simplex virus types 1 and 2, in comparison with the average for Russia in all the groups studied. The level of sensitization and the different severity of allergic reactions in the studied sample was 74%. In groups of volunteers infected with opisthorchiasis, the prevalence of allergic sensitization is higher than the group infected with herpes. The combination of allergic sensitization in herpes-infected patients is associated with the risk of recurrent course of infection, ie with the frequency and severity of clinical manifestations of the latter.
Pharmacological test with sildenafil at pulmonary hypertension assessing in children with congenital heart diseases
Authors: Yanulevich O. S. , Ivanov S. N. , Kovalyov I. A. , Krivoschyokov Ye. V. , Filippov G. P.
Published: June 2020

The paper considers the devised author’s method of pulmonary hypertension assessment in children with congenital heart diseases. 51 patients were made the test. According to the ECG data two types of reaction were noted after sildenafil intake: positive and negative. Positive reaction indicates pulmonary hypertension reversibility. This fact is the main condition for successful surgical heart disease correction.
Possibility radiological methods in diagnostics of visceral adiposity
Authors: Suslyaeva N. M.
Published: June 2020

Obesity is present in over 50% of men and 70% of women. Greater health risks development of cardio-vascular disease have been associated with the visceral obesity. Computed tomography is the reference method for intra-abdominal fat evaluation, but high cost, low availability and ionizing radiation risks prevent it from being a widely usable method. Ultrasound measurement of intra-abdominal distance between abdominal muscle and aorta, which has been shown to correlate well with computed tomography intra-abdominal fat measurements, is proposed together with other anthropometric measurements as an alternative means of predicting body fat and also confirmed as a reliable instrument for clinical and epidemiologic studies.
Morphological features of periodontal first premolars and molars
Authors: Khertek M. V.
Published: June 2020

The calculation and analysis of data on the morphofunctional organization of periodontal ligament with different surfaces (medial, distal, buccal and palatal) at various levels of the roots of the first molars and first premolars. Shown that the biomechanical load on teeth morphology of periodontal changes throughout the root, depending on the localization of zones of compression and tension.
The role apoptosis in dysregulations of lokal and system immunitet at the Helicobacter pilory-infection
Authors: Ageyeva Ye. S. , Shtygasheva O. V. , Iptyshev V. M. , Butorin N. N. , Tsukanov V. V. , Ryazantseva N. V.
Published: June 2020

The level of intracellular apoptosis regulators (cell death antagonists (Bcl-2) and agonists (CPP-32)), proliferation antigen Ki67 in lymphocytes of biopsy materials of the mucous coat of stomach at Helicobacter pylori-associated gastric ulcer and chronic gastritis in Khakassian aboriginal population and newcomers have been studied. The lymphocyte apoptosis in peripheral blood in aboriginal population was assessed. Changes in immunological indices were revealed in patients infected with Helicobacter pylori compared to healthy donors and newcomers. These changes were characterized by the more intense apoptotic lymphocyte death compared to the number of such cells in patients with chronic gastritis and in the control group. The role of apoptosis disfunctions in the regulation of local and system immunity at Helicobacter pylori infection is discussed.
To the 30th anniversary of the Children's Physiology and Pathology problem committee work
Authors: Balasheva I. I.
Published: June 2020

«Children physiology and pathology» problem committee has summed up the results of 30 years of work. The results of postgraduate and doctorate training program for the given period are presented. The modern scientific research trends were emphasized.
The outlooks for the adsorbent dressing based on nanostructural graphite on the bandage market of Russia
Authors: Vorobiyov V. M. , Shteinle A. V. , Ratkin A. V. , Khandorin G. P. , Khasanov O. L. , Dubov G. I. , Mazin V. I. , Solodkova T. V. , Ryazantseva N. V. , Chechina O. Ye. , Shteinle L. A.
Published: June 2020

The marketing research has been made to find out the outlooks for commercial activities and market entry for the graphitebased adsorbent dressing. The bandage market increase is caused by the wide application, growing requirement and low price. Domestic cheap ineffective bulky dressings prevail on the market but last years the tendency to the gain in sales of innovative, expensive and effective in treatment import bandages is being observed. The new graphite-based adsorbent dressing has good market prospects in connection with the segment increase, low business competition and high demand of modern effective bandages with adsorbent, wound healing and atraumatic properties.
Historical aspects of the use in medicine kumis
Authors: Kudayarova R. R. , Gilmutdinova L. T. , Yamaletdinov K. S. , Gilmutdinov A. R. , Gabdelhakova L. T. , Zinnatullin R. Kh.
Published: June 2020

The historical materials of the product fermented mares milk — kumis — in medicinal and recreational purposes. These data indicate that the mare is an effective nondrug capable to provide therapeutic and preventive effects for many diseases.
Dithizone injuring action to blood granulocytes and basal parts of intestine crypts
Authors: Yeschenko Yu. V. , Novitsky V. V. , Bovt V. D. , Yeschenko V. A. , Urazova O. I. , Grigorova N. V.
Published: June 2020

It was shown, that dithizone injection to rats induced zinc deficiency in blood granulocytes and Paneth cells. Phase changes of zinc content were observed in the cells. First phase (primary decrease of cytochemically detected zinc content in the cells) was a result of intravital binding of this metal to dithizone. Second one (permanent partial increase of cell zinc content) was a result of decomposition of the product of intravital reaction. Third phase (secondary decrease of cell zinc concentration) was connected with cell necrosis. Dithizone injection to animals also induced cell secretory material deficiency.
Glutathione system participation on neutrophils functional status during acute inflammation
Authors: Zhavoronok T. V.
Published: June 2020

There was conducted the study of glutathione system status (the content of reduced, oxidized, protein-bound glutathione, SHgroups of proteins and glutathionperoxydase activity) and functional properties (the production of hydroxyl radical, IL-8, TNF-α and myeloperoxidase activity) of neutrophils received from people with community-acquired pneumonia. There was revealed the role of reduced and protein-bound glutathione in the regulation of myeloperoxidase activity and production of hydroxyl radical by blood neutrophils when incubating cells with glutathione synthesis blocker de novo (buthioninesulfoximine). and catalase inhibitor (3-amino-1,2,4-triazole). It was ascertained that glutathione synthesis de novo is more important than catalase activity (inhibition by 3-amino 1,2,4-triasole) to support neutrophil functional condition.
Morphological evaluation of compatibility of ventricular myocardium and external restrictive elastic sac of the original construction made from titanium nickelide after its implantation during the experiment
Authors: Kazakov V. A. , Lezhnev A. A. , Shipulin V. M. , Krivoschyokov Ye. V. , Sukhodolo I. V.
Published: June 2020

The objective of this study is a morphological evaluation of compatibility of ventricular myocardium with the device of our original construction for restriction of heart chambers dilatation. In the experiment the device made from titanium nickelide was implanted into 8 outbred dogs with the previously induced experimental model of left ventricular aneurism. The animals were excluded from the experiment in 1, 3 and 6 months after implantation of an external restrictive elastic sac. Histological preparations of myocardium samples, which were in an immediate contact with titanium nickelide fibers were the subjects for studying of general tissue response to the presence of an implanted device. No data evidencing negative effect of an external restrictive elastic titanium nickelide sac on ventricular myocardium have been found. It means that an implanted sac has a satisfactory compatibility with biological tissues just as like as any other implant made from titanium nickelide.
Age features of lipid peroxidation and antioxidant protection processes in girls and women tofalar ethnic groups
Authors: Kolesnikova L. I. , Darenskaya M. A. , Dolgikh V. V. , Shenin V. A. , Dutova S. V. , Grebenkina L. A. , Dolgikh M. I.
Published: June 2020

Research objective: studying lipid peroxidation and antioxidant protection processes in girls and women of 3 age groups living in Tofalariya (ethnic tofalars). Spectrophotometric, fluorometric and statistic methods (Student’s parametrical criterion and Fisher's coefficient) were used. It was determined that decrease of lipid peroxidation and antioxidant protection processes activity takes place in puberty period. We marked increase concentration of lipid peroxidation products and retinol. The elder age period is characterized by the raised intensity of peroxidation processes.
Results pathomorphologic study of musculocutaneous tissue samplings with people who subject to influence a little doses of ionizing radiation
Authors: Porovsky Ya. V. , Nedosekov V. V. , Ryzhov A. I. , Tetenev F. F.
Published: June 2020

To study the influence of small doses of ionizing radiation on microvasculature, the skin-muscular biopsy in the lower leg region was performed in 33 liquidators or clean-up workers at the Chernobyl Nuclear Power Plant and 7 workers of a typical research nuclear reactor (RNR).A histological feature in the liquidators was the presence of the disseminated productive panvasculitis with pronounced lymphocytary infiltration of the vessel wall and sclerosis outcome in most microvasculature vessels, perivascular sclerosis. Changes in vessels of RNR workers increased with the increase а total doses from productive panvasculitis with involvement from few to most microvasculature vessels, formation of perivascular fibrosis and perivascular sclerosis. The revealed changes may be significant in the observed somatic pathology.
Pathogenetic aspects of acute upper urinary tract`s obstruction
Authors: Belyi L. Ye.
Published: June 2020

In the review questions of pathogenesis of acute upper urinary tract`s obstruction are considered. The critical analysis of existing theories of upper urinary tract`s motor activity carried out. The basis mechanisms of pathogenesis — disturbs of urodynamic and pathological renovascular changes are described.
Yevgeniya Mikhailovna Dumenova (tu the 100th anniversary)
Authors: Vengerovsky A. I.
Published: June 2020

Scientific biography of Evgeniya Michaylovna Dumenova, famous Russian pharmacologist, chief of Pharmacology Chair in Tomsk Medical Institute is presented.
Structural and functional peculiarities of spine deformity development in neurofibromatosis NF-1
Authors: Zaidman A. M. , Mikhailovsky M. V. , Zaviyalova Ye. L. , Suzdalov V. A. , Sadovoy M. A.
Published: June 2020

To study pathogenetic mechanisms of the development of spinal deformity in neurofibromatosis.

Structural components of the spine were presented as specimens obtained after surgical correction of spinal deformity performed in 10 children with III—IV grade scoliosis associated with neurofibromatosis.

Etiologic factor of the development of spinal deformity in neurofibromatosis is a mutation of the NF-1 gene in cells of ganglious lamella. Migration of cells carrying mutant gene into one of the sclerotome zones results in oncogene activation and intensive proliferation of chondro-, osteo-, and fibroblasts in the growth plate, intervertebral disc, and vertebral body.

Progressive development of the spinal deformity after surgical intervention is accounted both for proliferation of chondro- and fibroblasts in the vertebral body and intervertebral disc and for disturbance of the NF-1 and lumican genes expression.
Clinical and morphological features uterin corpus cellular leiomyoma
Authors: Mischenko Ye. V. , Grigoriyeva Ye. Ye. , Avdalyan A. M. , Klimachev V. V. , Klimacheva T. B.
Published: June 2020

Analysis of clinical-anamnestic and morphological features of a cellular and simple leiomyoma of a uterus is leading. Features of a leiomyoma of a uterus with cellular texture of the site are determined: young age, monthly since 15 years ((20,0 ± 4,6)%), often use ВМК ((38,7 ± 5,6)%), an infrequent combination to infringement of genesial function. Analysis of СD31, Ki-67, and Ag-NORproteins expression in the greater and smaller tumour which have been taken away from one macropreparation was carried out.
Morphophunctional features of blood mononuclear cells culture in patients with osteogenesis imperfecta: clinicodiagnostic observation
Authors: Khlusov I. A. , Saprina T. V. , Nechayev K. A. , Dvornichenko M. V. , Shevtsova N. M. , Zaytsev K. V. , Popkov A. V.
Published: June 2020

The use of intramedullary bioactive osteosynthesis combined with Ilizarov’s apparatus is promoting to correction of skeletal deformations and is allowing putting patients with osteogenesis imperfecta on their legs. Morphofunctional parameters of blood mononuclear cells can be considered as probable markers and predictors of osteogenesis imperfecta course and duration of patients rehabilitation.
An experiment of Kartalin liniment for palmar-plantar form psorias and other keratodermias
Authors: Dmitruk V. S.
Published: June 2020

Keratodermias can be isolated or can be a part of syndromes typical for other dermatological deceases. Investigation of clinical effectiveness of Kartalin liniment in complex therapy of palmar-plantar keratodermias was held with a group of 26 patients with different clinical variants of the deceases. Besides local treatment, the patients got systematic therapy corresponding to the standards of medical treatment for each nogological form.

For estimation of clinical effectiveness of the suggested complex of general and local arrangements there was done a calculation of the number of days spent in hospital white curing keratodermias. This showing made up 23 days in the examined group and positive clinical dynamics in the control group has been noticeable sense 33,7 day.
Potentialities of the ultrasonography by detection of the acromion types as external cause of impingment syndrome
Authors: Kinzersky A. Yu. , Turdakina I. N.
Published: June 2020

It is on record that the curved and hooked acromion types result in the lesion in the rotator cuff tendons. Research aim: to increase the informational content of ultrasound investigation of a glenohumeral joint using ultrasonic analysis of acromial morphology. To research is based on the comparison of radiographic findings of the acromion with the length of coraco-acromial ligament. Altogether 112 patients aged from 21 to 80 which complained the shoulder pain were examined. Among them there were 76 (67,9%) women and 36 (32,1%) men.

The length of the coracoacromial ligament was defined for each type of acromion process.

Conclusion: we found ultrasound equivalent (the length of coracoacromial ligament) for each type of acromion, which allows to reduce radiation exposure of the patients while their examination.
Indicators of a hemostasis in patients with hyperhomocysteinemia on a hemodialysis
Authors: Kharlamova U. V. , Ilyicheva O. Ye.
Published: June 2020

Inspection of 89 patients on a hemodialysis for the purpose of studying of feature hemostasiogram's indicators depending on level гомоцистеина is spent. At patients on a hemodialysis activation of intravascular curling of the blood, the most expressed at patients with hyperhomocysteinemia is revealed. Interrelation existence between concentration of homocysteine and hemostasiogram's indicators noted.
Cryosurgery of focal liver diseases
Authors: Alperovich B. I. , Merzlikin N. N. , Salo V. N. , Paramonova L. M. , Maksimov M. A. , Saipov M. B. , Yeskov I. M.
Published: June 2020

The results of cryosurgical treatment of 339 patients with various focal liver diseases are presented. The experience of using cryosurgical equipment designed and manufactured in the Tomsk Hepatological Center in the surgery of focal liver diseases is analyzed. The application of inventive instruments in the liver resection leads to a decrease in the intraoperative blood loss down to 30- 40% and favors the reduction of backsets, because the cryodestruction of liver stump after resection leads to the destruction of rest parts of parasitic tissue in the surgical zone. The use of cryosurgical techniques lowers the number of deaths down to 4.42%.
Endothelial dysfunction and hemostasis in acute myocardial infarction before and after Trombovazim therapy
Authors: Kotovshchikova Ye. F. , Buevich Ye. I. , Syulzhina Ye. N. , Tarasova I. N. , Vereschagin Ye. I. , Popova L. A.
Published: June 2020

We studied 57 patients with acute myocardial infarction (AMI) aged 20 to 63 years. Initially (day 25 from disease onset), Fibroblast growth factor (FGF), osteoprotegerin, vascular endothelial growth factor (VEGF-A), von Willebrand factor (vWF) were determined in patients’ blood by immunoenzyme method; hemostasis system was examined. The control group consisted of 15 healthy volunteers aged 19 to 50 years. The patients were divided into two groups: the major group was receiving Trombovazim in dosage 800 mg per day during 1 month together with the standard therapy of AMI, and the control group, which was receiving no Trombovazim. Control study of the dynamics of FGF, osteoprotegerin, VEGF-A, vWF, and hemostasis hemostasis parameters was performed after 1 month of treatment with Trombovazim. The inclusion of Trombovazim into the complex therapy of AMI was found to result in a decrease in FGF, osteoprotegerin, and VEGF-A levels due to the endothelial protection effect and apoptosis control.

The parameters of vascular-platelet and coagulation hemostasis components had no significant changes.
The neurobiofeedback cumulative effect on the electroencephalographic indexes in the high qualified athletes with the dominance of metabolic modulation of heart rate variability
Authors: Yeremeyeva O. V. , Kormilez V. S. , Yeremeyev S. I.
Published: June 2020

The aim was to investigate the electroencephalography indexes dynamic caused by neurofeedback in athletes. The main results are that the neurobiofeedback cumulative effect on the electroencephalographic indexes in the high qualified athletes with the dominance of metabolic modulation of heart rate variability is carried out. The conclusions are that the interlobar reciprocal actions reorganization in a brain and the general changing of quantitative electroencephalogram indexes of all standard diapasons of frequency are revealed both in the locus of biofeedback control and overall brain convex surface.
Investigation of rubella vaccine maked MICROGEN Federal State Company: study I trial
Authors: Mironov A. N. , Tsaan A. A. , Bushmenkov D. S. , Romanova A. A. , Sidorenko Ye. S. , Feldblum I. V.
Published: June 2020

Experts of the RPU «Microgene», developed the new domestic medication for prevention of rubella — The rubella vaccine cultural live, on the basis of the vaccine strain RA 27/3. After the safety of vaccine had been proved on laboratory animals, the clinical trial had been activated on volunteers.

The first phase of trial had been carried out on the women at the age of 18—25.

After introduction of medications (vaccine or production strain of vaccine) the volunteers had been observed during 42 days. Blood and urine sampling had been executed till vaccination and 28 days later after introduction of medications.

Results of trial presented safety, low reactogenicity and evident immunologic properties of medications. It permitted to start the next phase of the clinical trial on the basis of children’s volunteers.
Correction of cyclophosphan hepatotoxicity by water-soluble polysaccharides from Tussilago farfara and Acorus calamus
Authors: Safonova Ye. A. , Lopatina K. A. , Vetoshkina T. V. , Guriyev A. M. , Razina T. G. , Zuyeva Ye. P.
Published: June 2020

In experiments on rats with Walker-256 carcinosarcoma the ability of water-soluble polysaccharides from Tussilago farfara and Acorus calamus influence on efficiency antineoplastic therapy and hepatotoxicity investigated. Polysaccharides reduce a level of liver enzymes in blood serum of rats at cyclophosphamide damaged liver, as well as increase the antimetastatic effect of cytostatics. Water-soluble polysaccharides from Acorus calamus restore most efficiently biochemical disturbances at cyclophosphamide intoxication.
Argon enhanced coagulation in laparoscopic cholecystectomy
Authors: Malikov Ya. V.
Published: June 2020

At present argon enhanced coagulation is widely used to handle the gallbladder in laparoscopic cholecystectomy, which may lead to worsening intraabdominal hypertension, increasing the risk of postoperative complications. When analyzing the results of surgical treatment of patients operated concerning cholelithiasis with use of various techniques, it was found that the argon enhanced coagulation provides a reliable hemo-and cholestasis, reduces the duration of the operation, although it may increase the risk of adverse effects.
Effect of antihypertensive therapy on the life quality of patients with hypertensive encephalopathy
Authors: Gavrilyuk O. V. , Mashin V. V. , Belova L. A. , Gorbunov V. I. , Ruzov V. I. , Nazina L. V.
Published: June 2020

To analyze patients with hypertensive encephalopathy (HE) in the course of antihypertensive therapy (AT) clinical psychological and neurological characteristics in dynamics of 6 months after the first screening were estimated. 107 patients with HE of I—III stages and 30 controls matched for age and sex were examined. The clinical, ultrasonic diagnostics and quality of life (QL) index were applied. In the process of HE development and progression decreases of the physical and psychological constituents of health were shown, pain barrier was decreased. The QL analysis shown that in the process of AT in dynamics the physical and psychological constituents of health increase.
The role of some risk factors in the development of amyotrophic lateral sclerosis in big industrial city in Western Siberia
Authors: Lebedev A. V. , Doronin B. M. , Gribacheva I. A.
Published: June 2020

On examination of 78 people with accurate amyotrophic lateral sclerosis the role of some risk factors in the development and the character of the flow of the disease was analyzed. The received findings don't allow excluding the participation of the viruses of herpes and cytomegalovirus in the emergence and development of amyotrophic lateral sclerosis. The most important is the observance of a hypocaloric diet, the prevalence of eating meat products, the availability of guidelines for the transfer of poliomyelitis, rheumatism, herpes infection, acute psycho-emotional stress for the 6 months before disease onset and some others.
Secondary hypogonadism after surgical treatment of patients with tumors of the chiasmosellar aria
Authors: Kan Ya. A. , Zhestikova M. G.
Published: June 2020

A frequency of secondary hypogonadism after surgical treatment of patients with tumors of the chiasmosellar aria was defined. 30 patients were examined. A secondary hypogonadism was revealed in 70% of cases. The average levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) both in male in female were lowered or were on the low bound of the norm. This phenomenon denotes to the secondary nature of the hypogonadism. Most often secondary hypogonadism developed in patients operated apropos of the craniopharyngeoma and prolactinoma.
Matrix metalloproteinase 9, superoxide dismutase and lipid peroxidation in preterm newborns with perinatal hypoxia
Authors: Korenovsky Yu. V. , Elchaninova S. A. , Fadeyeva N. I.
Published: June 2020

The perinatal hypoxia (PH) in preterm newborns is associated with elevated levels of matrix metalloproteinase 9 (MMP-9), superoxide dismutase (SOD) and thiobarbituric acid reactive substances in umbilical cord blood plasma. The severity of PH Apgar scores correlated with SOD (r = –0,40; p = 0,006) and MMP-9 (r = 0,36; p = 0,023). It is assumed that the SOD increase prevents the reactive oxygen species mediated activation of MMP-9, which destroy the collagen of the basement membrane of the bloodbrain barrier.
Morphology of the epoophoron in women with benign ovarian tumor
Authors: Kokh L. I. , Perelmuter V. M. , Tardaskina A. V. , Dorosh T. N.
Published: June 2020

We studied the epoophoron in women with benign ovarian tumor using morphological methods. It was established that the structure epoophoron in women with benign ovarian tumors, there are significant differences compared with controls. This manifests itself in reducing the number of tubules, increase in their specific area, outer and inner diameter, the height of the epithelium, the presence of secretions in the lumen.