bluuebunny/crossref_metadata_2025 huggingface dataset:
A Systematic Review of the Inclusion of Non-Inflammatory Ultrasonographic Enthesopathy Findings in Enthesitis Scoring Indices
Authors: Mascarenhas Sheryl , Couette Nina
Published: April 2021

Ultrasound has advanced the diagnosis and management of patients with inflammatory rheumatic conditions. It can be used to identify and monitor enthesitis, a cardinal feature of spondyloarthropthies. Several enthesitis scoring systems utilizing ultrasound to determine entheseal involvement have been developed. These scoring systems generally rely on determining the presence or absence of erosions, tendon enlargement, power Doppler signal, or enthesophytes. This systematic review identified ultrasound scoring systems that have been utilized for evaluating enthesitis and what key components derive the score. Review of these scoring systems, however, demonstrated confounding as some of the score components including enthesophytes may be seen in non-inflammatory conditions and some components including erosions can be seen from chronic damage, but not necessarily indicate active inflammatory disease. What is furthermore limiting is that currently there is not an agreed upon term to describe non-inflammatory enthesopathies, further complicating these scoring systems. This review highlights the need for a more comprehensive ultrasound enthesopathy scoring index.
Infantile Brain Tumors: A Review of Literature and Future Perspectives
Authors: Simone Valeria , Rizzo Daniela , Cocciolo Alessandro , Caroleo Anna Maria , Carai Andrea , Mastronuzzi Angela , Tornesello Assunta
Published: April 2021

Brain tumors in infants including those diagnosed in fetal age, newborns and under a year old represent less than 10% of pediatric nervous system tumors and present differently when compared with older children in terms of clinical traits, location and histology. The most frequent clinical finding is a macrocephaly but non-specific symptoms can also be associated. The prognosis is usually poor and depends on several factors. Surgery continues to be the main option in terms of therapeutic strategies whereas the role of chemotherapy is not yet well defined and radiotherapy is exceptionally undertaken. In view of this situation, a molecular characterization could assist in providing therapeutic options for these tumors. This review highlights the recent advances in the diagnosis and treatment of brain tumors in infants with a particular focus on the molecular landscape and future clinical applications.
Machine-Learning-Based Rehabilitation Prognosis Prediction in Patients with Ischemic Stroke Using Brainstem Auditory Evoked Potential
Authors: Sohn Jangjay , Jung Il-Young , Ku Yunseo , Kim Yeongwook
Published: April 2021

To evaluate the feasibility of brainstem auditory evoked potential (BAEP) for rehabilitation prognosis prediction in patients with ischemic stroke, 181 patients were tested using the Korean version of the modified Barthel index (K-MBI) at admission (basal K-MBI) and discharge (follow-up K-MBI). The BAEP measurements were performed within two weeks of admission on average. The criterion between favorable and unfavorable outcomes was defined as a K-MBI score of 75 at discharge, which was the boundary between moderate and mild dependence in daily living activities. The changes in the K-MBI scores (discharge-admission) were analyzed by nonlinear regression models, including the artificial neural network (ANN) and support vector machine (SVM), with the basal K-MBI score, age, and interpeak latencies (IPLs) of the BAEP (waves I, I–III, and III–V). When including the BAEP features, the correlations of the ANN and SVM regression models increased to 0.70 and 0.64, respectively. In the outcome prediction, the ANN model with the basal K-MBI score, age, and BAEP IPLs exhibited a sensitivity of 92% and specificity of 90%. Our results suggest that the BAEP IPLs used with the basal K-MBI score and age can play an adjunctive role in the prediction of patient rehabilitation prognoses.
Cleft Candidate Genes and Their Products in Human Unilateral Cleft Lip Tissue
Authors: Vaivads Mārtiņš , Akota Ilze , Pilmane Māra
Published: April 2021

Cleft lip and palate are common congenital pathologies that affect the human population worldwide. The formation of cleft lip is associated with multiple genes and their coded proteins, which regulate the development of craniofacial region, but the exact role of these factors is not always clear. The use of morphological studies for evaluation of human cleft-affected tissue has been limited because of insufficiency of available pathological material. The aim of this study was to detect and compare the immunohistochemical expression of cleft candidate gene coded proteins (DLX4, MSX2, HOXB3, SHH, PAX7, SOX3, WNT3A, and FOXE1) in the non-syndromic unilateral cleft lip patient tissue and control group tissue. A semiquantitative counting method was used to evaluate the tissue in biotin-streptavidin-stained slides. Statistically significant differences between the patient and control groups were found for the number of immunoreactive structures for SHH (p = 0.019) and FOXE1 (p = 0.011) in the connective tissue and SOX3 (p = 0.012) in the epithelium. Multiple statistically significant very strong and strong correlations were found between the immunoreactives in cleft-affected tissue. These significant differences and various correlations indicate that multiple morphopathogenetic pathways are possibly involved in unilateral cleft lip pathogenesis. Therefore, we further discuss these possible interactions.
The Intra-EU Value Chain: An Approach to Its Economic Dimension and Environmental Impact
Authors: Rodil-Marzábal Óscar , Campos-Romero Hugo
Published: April 2021

This paper aims to analyze the economic dimension and environmental impact of intra-EU value-added generation linked to global value chains (GVCs) through input-output analysis. For this purpose, information has been collected from TiVA (Trade in Value Added, OECD) and Eora databases for the years 2005 and 2015. From an economic perspective, the results point to a strengthening of the value-added generated within Factory Europe. From an environmental perspective, all EU28 members have reduced their exports-related impacts in intensity-emissions terms, but not all of them in the same degree. An approach to the environmental Kuznets curve (EKC) has also been carried out through a panel data model. The results show a positive impact of the participation in intra-EU value chain (Factory Europe) on CO2 emissions per capita. Further, an inverted U-shaped curve for CO2 emissions is found for the period 2005–15. In this sense, European economies with lower development levels (many Eastern and Southern countries) seem to be still on the rising segment of the curve, while the more developed ones seem to be on the decreasing segment. These results highlight the need to design global monitoring and prevention mechanisms to tackle growing environmental challenges and the need to incorporate specific actions associated with the GVCs activity.
Indirect Effective Controlled Split Source Inverter-Based Parallel Active Power Filter for Enhancing Power Quality
Authors: Panati Poornima Udaychandra , Ramasamy Sridhar , Ahsan Mominul , Haider Julfikar , Rodrigues Eduardo M.G.
Published: April 2021

The existing solutions for reducing total harmonic distortion (THD) using different control algorithms in shunt active power filters (SAPFs) are complex. This work proposes a split source inverter (SSI)-based SAPF for improving the power quality in a nonlinear load system. The advantage of the SSI topology is that it is of a single stage boost inverter with an inductor and capacitor where the conventional two stages with an intermediate DC-DC conversion stage is discarded. This research proposes inventive control schemes for SAPF having two control loops; the outer control loop regulates the DC link voltage whereas the inner current loop shapes the source current profile. The control mechanism implemented here is an effective, less complex, indirect scheme compared to the existing time domain control algorithms. Here, an intelligent fuzzy logic control regulates the DC link voltage which facilitates reference current generation for the current control scheme. The simulation of the said system was carried out in a MATLAB/Simulink environment. The simulations were carried out for different load conditions (RL and RC) using a fuzzy logic controller (FLC) and PI controllers in the outer loop (voltage control) and hysteresis current controller (HCC) and sinusoidal pulse width modulation (SPWM) in the inner loop (current control). The simulation results were extracted for dynamic load conditions and the results demonstrated that the THD can be reduced to 0.76% using a combination of SPWM and FLC. Therefore, the proposed system proved to be effective and viable for reducing THD. This system would be highly applicable for renewable energy power generation such as Photovoltaic (PV) and Fuel cell (FC).
Bifacial Photovoltaics 2021: Status, Opportunities and Challenges
Authors: Kopecek Radovan , Libal Joris
Published: April 2021

In this paper we summarize the status of bifacial photovoltaics (PV) and explain why the move to bifaciality is unavoidable when it comes to e.g., lowest electricity generation costs or agricultural PV (AgriPV). Bifacial modules—those that are sensitive to light incident from both sides—are finally available at the same price per watt peak as their standard monofacial equivalents. The reason for this is that bifacial solar cells are the result of an evolution of crystalline Si PV cell technology and, at the same time, module producers are increasingly switching to double glass modules anyway due to the improved module lifetimes, which allows them to offer longer product warrantees. We describe the general properties of the state-of-the-art bifacial module, review the different bifacial solar cells and module technologies available on the market, and summarize their average costs. Adding complexity to a module comes with the increase of possible degradation mechanisms, requiring more thorough testing, e.g., for rear side PID (Potential Induced Degradation). We show that with the use of bifacial modules in fixed tilt systems, gains in annual energy yield of up to 30% can be expected compared to the monofacial equivalent. With the combination of bifacial modules in simple single axis tracking systems, energy yield increases of more than 40% can be expected compared to fixed tilt monofacial installations. Rudimentary simulations of bifacial systems can be performed with commercially available programs. However, when more detailed and precise simulations are required, it is necessary to use more advanced programs such as those developed at several institutes. All in all, as bifacial PV—being the most cost-effective PV solution—is now becoming also bankable, it is becoming the overall best technology for electricity generation.
Cellulose Microfibril and Micronized Rubber Modified Asphalt Binder
Authors: Li Ang , Danladi Abdu A. , Vallabh Rahul , Yakubu Mohammed K. , Ishiaku Umar , Theyson Thomas , Seyam Abdel-Fattah M.
Published: April 2021

Cellulose microfibrils (CMFs) and micronized rubber powder (MRP) can be derived from low or negative-cost agricultural/industrial waste streams and offer environment-friendly and cost-effective pathways to develop engineering products. This study investigated the efficacy of adding these micromodifiers on the performance characteristics of asphalt binders. In this work, samples were produced using a mixture of slow-setting anionic asphalt emulsion with various combinations of MRP (at 0, 2 and 10 wt %) and four types of CMFs (hydrophobic and hydrophilic with crystalline ratios of 86% and 95%) at 0, 2 and 5 wt %. The performance of modified asphalt samples was assessed by penetration depth (PD), softening point (SP), and penetration index (PI). Linear regression analysis showed that adding CMFs and/or MRP reduced PD and increased SP values. The type of CMFs significantly affected the performance, which becomes more distinct with the increased weight content of CMFs. While hydrophilic CMFs caused increases in SP and PI values, no clear trend was seen to determine the effect of CMF crystallinity. It was also discovered that the combined addition of CMF and MRP achieved similar PI values at lower total weight content compared to using MRP alone.
Numerical Simulation of Propagation and Run-Up of Long Waves in U-Shaped Bays
Authors: Pudjaprasetya Sri R. , Risriani Vania M. , Iryanto
Published: April 2021

Wave propagation and run-up in U-shaped channel bays are studied here in the framework of the quasi-1D Saint-Venant equations. Our approach is numerical, using the momentum conserving staggered-grid (MCS) scheme, as a consistent approximation of the Saint-Venant equations. We carried out simulations regarding wave focusing and run-ups in U-shaped bays. We obtained good agreement with the existing analytical results on several aspects: the moving shoreline, wave shoaling, and run-up heights. Our findings also confirm that the run-up height is significantly higher in the parabolic bay than on a plane beach. This assessment shows the merit of the MCS scheme in describing wave focusing and run-up in U-shaped bays. Moreover, the MCS scheme is also efficient because it is based on the quasi-1D Saint-Venant equations.
The Asymmetric Emotional Associations to Beverages: An Approach through the Theory of Positive Asymmetry
Authors: Calvo-Porral Cristina , Rivaroli Sergio , Orosa-González Javier
Published: April 2021

Consumers experience mainly positive emotions in response to food products, and the reason is that, for most individuals, eating and drinking is a pleasurable experience. On this premise, in light of the Theory of Positive Asymmetry, this study answers the following question: “What emotions prevail in beverage consumption?” A MANOVA test was developed comparing emotions associated with spirits (n = 247), alcoholic beverages (n = 560) and non-alcoholic beverages (n = 254). The findings report that the positive asymmetry of emotions occurs in beverage consumption, regardless of the type of beverage product, since pleasant or positive emotions are primarily associated with beverages’ consumption. The analysis suggests that individuals predominantly associate beverages with pleasant emotions, regardless of the type of beverage, while the level of alcohol content seems to be influencing the different emotions and affect. The research results provide valuable insights to help managers and marketers understand the choice and preference for different beverages.
Detection, Distribution and Health Risk Assessment of Toxic Heavy Metals/Metalloids, Arsenic, Cadmium, and Lead in Goat Carcasses Processed for Human Consumption in South-Eastern Nigeria
Authors: Njoga Emmanuel O. , Ezenduka Ekene V. , Ogbodo Chiazor G. , Ogbonna Chukwuka U. , Jaja Ishmael F. , Ofomatah Anthony C. , Okpala Charles Odilichukwu R.
Published: April 2021

Notwithstanding the increased toxic heavy metals/metalloids (THMs) accumulation in (edible) organs owed to goat′s feeding habit and anthropogenic activities, the chevon remains increasingly relished as a special delicacy in Nigeria. Specific to the South-Eastern region, however, there is paucity of relevant data regarding the prevalence of THMs in goat carcasses processed for human consumption. This work was, therefore, aimed to investigate the detection, distribution and health risk assessment of THMs in goat carcass processed for human consumption in South-Eastern Nigeria. To achieve this, a total of 450 meat samples (kidney, liver and muscle) were evaluated from 150 randomly selected goat carcasses processed in two major slaughterhouses in Enugu State. The detection, distribution, as well as health risk assessment parameters followed standard procedures. Results revealed that at least one THM was detected in 56% of the carcasses. Mean concentrations of arsenic (As) were 0.53 ± 0.10 mg/kg, 0.57 ± 0.09 mg/kg and 0.45 ± 0.08 mg/kg, lead (Pb) were 0.48 ± 0.38 mg/kg, 0.45 ± 0.24 mg/kg and 0.82 ± 0.39 mg/kg, cadmium (Cd) was 0.06 ± 0.32 mg/kg, 0.02 ± 0.00 mg/kg, and 0.02 ± 0.00 mg/kg for kidney, liver and muscle tissues, respectively. The estimated daily intakes (EDI) for all THMs were above the recommended safe limits. The target hazard quotient (THQ) and hazard index (HI) computed for all As, Cd and Pb fell below unity in all the studied organs, which indicated no non-carcinogenic risks. Curtailing the anthropogenic activities that aid the THM-contamination in goat production/processing lines is recommended. Screening for THM-contamination in Nigerian slaughterhouses is imperative, so as to ascertain the toxicological safety of meats intended for human consumption.
Proteomic Characterization of Bacteriophage Peptides from the Mastitis Producer Staphylococcus aureus by LC-ESI-MS/MS and the Bacteriophage Phylogenomic Analysis
Authors: Abril Ana G. , Carrera Mónica , Böhme Karola , Barros-Velázquez Jorge , Cañas Benito , Rama José-Luis R. , Villa Tomás G. , Calo-Mata Pilar
Published: April 2021

The present work describes LC-ESI-MS/MS MS (liquid chromatography-electrospray ionization-tandem mass spectrometry) analyses of tryptic digestion peptides from phages that infect mastitis-causing Staphylococcus aureus isolated from dairy products. A total of 1933 nonredundant peptides belonging to 1282 proteins were identified and analyzed. Among them, 79 staphylococcal peptides from phages were confirmed. These peptides belong to proteins such as phage repressors, structural phage proteins, uncharacterized phage proteins and complement inhibitors. Moreover, eighteen of the phage origin peptides found were specific to S. aureus strains. These diagnostic peptides could be useful for the identification and characterization of S. aureus strains that cause mastitis. Furthermore, a study of bacteriophage phylogeny and the relationship among the identified phage peptides and the bacteria they infect was also performed. The results show the specific peptides that are present in closely related phages and the existing links between bacteriophage phylogeny and the respective Staphylococcus spp. infected.
Flavor and Metabolite Profiles of Meat, Meat Substitutes, and Traditional Plant-Based High-Protein Food Products Available in Australia
Authors: Kaczmarska Kornelia , Taylor Matthew , Piyasiri Udayasika , Frank Damian
Published: April 2021

Demand for plant-based proteins and plant-based food products is increasing globally. This trend is driven mainly by global population growth and a consumer shift towards more sustainable and healthier diets. Existing plant-based protein foods and meat mimetics often possess undesirable flavor and sensory properties and there is a need to better understand the formation of desirable meat-like flavors from plant precursors to improve acceptance of novel high-protein plant foods. This study aimed to comprehensively characterize the non-volatile flavor metabolites and the volatiles generated in grilled meat (beef, chicken, and pork) and compare these to commercially available meat substitutes and traditional high-protein plant-based foods (natto, tempeh, and tofu). Solid phase microextraction with gas-chromatography mass-spectrometry was used for elucidation of the flavor volatilome. Untargeted characterization of the non-volatile metabolome was conducted using Orbitrap mass spectrometry and Compound DiscovererTM datamining software. The study revealed greater diversity and higher concentrations of flavor volatiles in plant-based foods in comparison to grilled meat, although the odor activity of specific volatiles was not considered. On average, the total amount of volatiles in plant-based products were higher than in meat. A range of concentrations of free amino acids, dipeptide, tripeptides, tetrapeptides, nucleotides, flavonoids, and other metabolites was identified in meat and plant-based foods.
Genomic Imprinting at the Porcine PLAGL1 Locus and the Orthologous Locus in the Human
Authors: Ahn Jinsoo , Hwang In-Sul , Park Mi-Ryung , Hwang Seongsoo , Lee Kichoon
Published: April 2021

Implementation of genomic imprinting in mammals often results in cis-acting silencing of a gene cluster and monoallelic expression, which are important for mammalian growth and function. Compared with widely documented imprinting status in humans and mice, current understanding of genomic imprinting in pigs is relatively limited. The objectives of this study were to identify DNA methylation status and allelic expression of alternative spliced isoforms at the porcine PLAGL1 locus and assess the conservation of the locus compared to the orthologous human locus. DNA methylome and transcriptome were constructed using porcine parthenogenetic or biparental control embryos. Using methylome, differentially methylated regions between those embryos were identified. Alternative splicing was identified by differential splicing analysis, and monoallelic expression was examined using single nucleotide polymorphism sites. Moreover, topological boundary regions were identified by analyzing CTCF binding sites and compared with the boundary of human orthologous locus. As a result, it was revealed that the monoallelic expression of the PLAGL1 gene in porcine embryos via genomic imprinting was maintained in the adult stage. The porcine PLAGL1 locus was largely conserved in regard to maternal hypermethylation, tissue distribution of mRNA expression, monoallelic expression, and biallelic CTCF-binding, with exceptions on transcript isoforms produced by alternative splicing instead of alternative promoter usage. These findings laid the groundwork for comparative studies on the imprinted PLAGL1 gene and related regulatory mechanisms across species.
Coseismic Ground Displacement after the Mw6.2 Earthquake in NW Croatia Determined from Sentinel-1 and GNSS CORS Data
Authors: Bjelotomić Oršulić Olga , Markovinović Danko , Varga Matej , Bašić Tomislav
Published: April 2021

At the very end of the year 2020, on 29 December, a hazardous earthquake of Mw = 6.2 hit the area of Petrinja and its surroundings, in the NW of Croatia. The earthquake was felt across the area of 400 km, leaving an inconceivable damage in the vicinity of the epicenter, devastated towns and ruined lives. In order to map the spreading of earthquake waves and to determine the coseismic ground displacement after the mainshock, we have analyzed open satellite radar images of Sentinel-1 and the GNSS data from the nearest CORS station related to the epicenter, along with the seismic faults. In this paper, we addressed and mapped the displacement linear surface ruptures detected by the SAR interferometry. The results show the vertical ground displacement to the extent of −12 cm in the southern area and up to 22 cm in the north-western part of a wide area struck by the earthquake impact, related to the epicenter. Subsidence and uplift in a range of ±5 cm over a wider affected area indicate a spatial extent and hazardous impact made by the earthquake. The ground displacement of 30 cm to the West and 40 cm to the East has been identified considering the intersection of Pokupsko and Petrinja strike-slip fault system in the seismic zone of Pannonian basin. Accordingly, we obtained matching results of 5 cm south-easting shift and −3 cm subsidence on Sisak GNSS CROPOS station, addressing the tectonic blocks movement along the activated complex fault system. The results compared with the geology data confirm the existence of two main faults; the Pokupsko and the Petrinja strike-slip faults and interpret the occurrence of secondary post-seismic events over the observed area.
Self-Care in Heart Failure Inpatients: What Is the Role of Gender and Pathophysiological Characteristics? A Cross-Sectional Multicentre Study
Authors: Delgado Bruno , Lopes Ivo , Mendes Tânia , Lopes Patrícia , Sousa Luís , López-Espuela Fidel , Preto Leonel , Mendes Eugénia , Gomes Bárbara , Novo André
Published: April 2021

Heart failure is often characterised by low exercise capacity and a great impairment of performance in the activities of daily living. The correct management of the disease can prevent the worsening of symptoms and promote a better quality of life. The aims of this study are to understand the relationship of gender and pathophysiological characteristics with self-care behaviour and to evaluate the self-care behaviour in a sample of Portuguese heart failure inpatients, using the Self-Care of Heart Failure Index (SCHFI). A cross-sectional multicentre study enrolling 225 heart failure inpatients from eight hospitals from Portugal was performed. At admission, each patient’s functional capacity was evaluated as well as their self-care behaviour, using the SCHFI Portuguese v6.2. A comparison between self-care behaviour with gender was performed. The patients’ mean age was 68.4 ± 10.7 years old, 68% were male and 82.3% had reduced ejection fraction. A mean value of 47.9, 35.6 and 38.8 points was found in the SCHFI score of the sections self-care maintenance, self-care management and self-care confidence, respectively. Heart failure inpatients present inadequate levels of self-care behaviour. The results do not suggest a relationship between gender and pathophysiological characteristics with self-care behaviour.
Performance of (Instrumental) Activities of Daily Living and Physical Capacity in Spanish Adults with Intellectual Disabilities: A Cross-Sectional Pilot Study
Authors: Delgado-Lobete Laura , Montes-Montes Rebeca , Freire Carlos , Ferradás María del Mar
Published: April 2021

Performance in basic and instrumental activities of daily living (ADL; IADL) is an essential indicator of daily functioning and health of people with intellectual disabilities (ID). The aims of this pilot study were to describe the profile of ADL and IADL performance in Spanish adults with ID, and to examine its association with functional physical skills. The Waisman Activities of Daily Living Scale for adolescents and adults with developmental disabilities (W-ADL) scale was administered to the caregivers of twenty adults with ID (mean age = 41.0, SD = 10.1; women = 75.0%). In addition, dynamic balance and maximum walking speed (MWS), lower-body strength, aerobic capacity and manual dexterity of participants were individualized assessed. The results showed that 40% of adults with ID were completely independent in ADL, but all participants reported activity limitations in at least one IADL. Dynamic balance and MWS, lower-body strength and manual dexterity showed significant and moderate-to-strong correlations with daily functioning (r = 0.495–0.814; p < 0.05). Linear regression analysis indicated that lower-body strength and manual dexterity significantly predicted activity performance in adults with ID (adjusted R2 = 0.816, p = 0.004–0.016). This study highlights the need to support the performance of both ADL and IADL and to promote physical fitness in Spanish community-based care centers for adults with ID.
Psychiatric Comorbidity in Mexican Adolescents with a Diagnosis of Eating Disorders Its Relationship with the Body Mass Index
Authors: Ruiz-Ramos David , Martínez-Magaña José Jaime , García Ana Rosa , Juarez-Rojop Isela Esther , Gonzalez-Castro Thelma Beatriz , Tovilla-Zarate Carlos Alfonso , Sarmiento Emmanuel , López-Narvaez María Lilia , Nicolini Humberto , Genis-Mendoza Alma Delia
Published: April 2021

The prevalence of comorbid psychiatric disorders among patients with eating disorders (ED) is higher than the general population. Individuals diagnosed with eating disorders have changes in their body mass index which could promote severe metabolic disruptions. This study aimed (1) to report the prevalence of comorbid psychiatric disorders among a Mexican adolescent sample diagnosed with eating disorders, (2) to compare our results with the prevalence of psychiatric disorders reported from a national survey of mental health of adolescents, (3) to compare the presence of psychiatric comorbidities between ED diagnoses, and (4) to explore the relationship of these comorbidities with the body mass index. In the study, we included 187 Mexican adolescents diagnosed with eating disorders. The psychiatric comorbidities were evaluated using the Mini International Neuropsychiatric Interview for children/adolescents, and a revised questionnaire on eating and weight patterns. We found that 89% of the Mexican adolescents diagnosed with ED had another psychiatric comorbidity. Major depressive disorder (52.40%) and suicide risk (40%) were the most prevalent comorbidities. Attention and deficit hyperactivity disorder (ADHD) prevalence was different between ED diagnosis, and adolescents with binge-eating disorder and ADHD had the higher body mass index. Our results showed that in this sample of Mexican adolescents, the presence of comorbidities could impact body mass index. This emphasizes the importance that clinicians take into consideration the presence of psychiatric comorbidities to achieve an integrative treatment for adolescents diagnosed with ED.
Differences in Maturity and Anthropometric and Morphological Characteristics among Young Male Basketball and Soccer Players and Non-Players
Authors: Toselli Stefania , Campa Francesco , Maietta Latessa Pasqualino , Greco Gianpiero , Loi Alberto , Grigoletto Alessia , Zaccagni Luciana
Published: April 2021

Background: An aspect that influences sport performance is maturation status, since, within the same chronological age group, boys who have advanced maturation outperform their late maturing peers in tests of muscular strength, power, and endurance. Therefore, the aims of the present study were: (i) to investigate the differences in biological maturation and anthropometric and morphological characteristics among three groups of Italian adolescents, two of which were sportive (practicing basketball and football) and one non-sportive, and (ii) to identify the anthropometric and morphological predictors that best discriminate these three groups. Methods: Sixty-one basketball and 62 soccer players and 68 non-sportive youths were measured (mean age = 13.0 ± 1.1 y). Anthropometric characteristics were taken and body mass index, cormic index, body composition parameters, and somatotype were derived. An estimation of maturity status was carried out considering the years from peak height velocity (PHV). Two-way 3 × 3 ANOVAs was performed on all anthropometric characteristics to test the differences within sport groups and maturity status groups. Discriminant function analysis (stepwise criteria) was then applied to anthropometric and body composition variables to classify subjects into the three different sport categories. Results: Differences in anthropometric characteristics were detected among the three groups. For somatotype, differences among all of the considered groups were higher for endomorphy (p < 0.001; effect size = 0.13). Biological maturity influences the differences in the anthropometric characteristics and body composition among subjects of the same chronological age during adolescence. The variables that best discriminated the three groups were represented by body composition parameters, body proportions, and body build. Conclusions: This study confirms that boys who practice sport present healthier body composition parameters, with lower level of fat parameters. The assessment of maturity status is a fundamental factor in explaining anthropometric and body composition differences among peers in this period. Its comprehension may assist coaches and technical staff in optimizing competitive efficiency and monitoring the success of training regimes.
Interprofessional and Intraprofessional Communication about Older People’s Medications across Transitions of Care
Authors: Manias Elizabeth , Bucknall Tracey , Woodward-Kron Robyn , Hughes Carmel , Jorm Christine , Ozavci Guncag , Joseph Kathryn
Published: April 2021

Communication breakdowns contribute to medication incidents involving older people across transitions of care. The purpose of this paper is to examine how interprofessional and intraprofessional communication occurs in managing older patients’ medications across transitions of care in acute and geriatric rehabilitation settings. An ethnographic design was used with semi-structured interviews, observations and focus groups undertaken in an acute tertiary referral hospital and a geriatric rehabilitation facility. Communication to manage medications was influenced by the clinical context comprising the transferring setting (preparing for transfer), receiving setting (setting after transfer) and ‘real-time’ (simultaneous communication). Three themes reflected these clinical contexts: dissemination of medication information, safe continuation of medications and barriers to collaborative communication. In transferring settings, nurses and pharmacists anticipated communication breakdowns and initiated additional communication activities to ensure safe information transfer. In receiving settings, all health professionals contributed to facilitating safe continuation of medications. Although health professionals of different disciplines sometimes communicated with each other, communication mostly occurred between health professionals of the same discipline. Lack of communication with pharmacists occurred despite all health professionals acknowledging their important role. Greater levels of proactive preparation by health professionals prior to transfers would reduce opportunities for errors relating to continuation of medications.
Assembly of the Cardiac Pacemaking Complex: Electrogenic Principles of Sinoatrial Node Morphogenesis
Authors: Easterling Marietta , Rossi Simone , Mazzella Anthony J , Bressan Michael
Published: April 2021

Cardiac pacemaker cells located in the sinoatrial node initiate the electrical impulses that drive rhythmic contraction of the heart. The sinoatrial node accounts for only a small proportion of the total mass of the heart yet must produce a stimulus of sufficient strength to stimulate the entire volume of downstream cardiac tissue. This requires balancing a delicate set of electrical interactions both within the sinoatrial node and with the downstream working myocardium. Understanding the fundamental features of these interactions is critical for defining vulnerabilities that arise in human arrhythmic disease and may provide insight towards the design and implementation of the next generation of potential cellular-based cardiac therapeutics. Here, we discuss physiological conditions that influence electrical impulse generation and propagation in the sinoatrial node and describe developmental events that construct the tissue-level architecture that appears necessary for sinoatrial node function.
Lipodystrophy as a Late Effect after Stem Cell Transplantation
Authors: Tews Daniel , Schulz Ansgar , Denzer Christian , von Schnurbein Julia , Ceccarini Giovanni , Debatin Klaus-Michael , Wabitsch Martin
Published: April 2021

Survivors of childhood cancer are at high risk of developing metabolic diseases in adulthood. Recently, several patients developing partial lipodystrophy following hematopoietic stem cell transplantation (HSCT) have been described. In this review, we summarize the cases described so far and discuss potential underlying mechanisms of the disease. The findings suggest that HSCT-associated lipodystrophies may be seen as a novel form of acquired lipodystrophy.
Impact of Breastfeeding and Cosleeping on Early Childhood Caries: A Cross-Sectional Study
Authors: Carrillo-Díaz María , Ortega-Martínez Ana Raquel , Ruiz-Guillén Ana , Romero-Maroto Martín , González-Olmo María José
Published: April 2021

The type and duration of breastfeeding can be key factors in the development of early childhood caries (ECC). The association between nighttime feeding and ECC was investigated. Specifically, whether cosleeping is a potential mediator of children’s oral health was investigated, considering many of the etiological factors of caries. In this cross-sectional study, 212 children (aged 2–4 years) from Madrid (Spain) who breastfed at night were examined to assess the mean decayed/filled primary teeth (dft) index, and a questionnaire was administered to the mothers to collect data on the practice of breastfeeding and cosleeping and its duration, the number of nighttime feeding sessions, sugar content in the diet, dental hygiene habits, and age at first dental visit. The dft index was lower in the group that breastfed for less than 18 months (p = 0.02). In addition, there were significant differences in the dft index in the group breastfeeding for more than 18 months between those who coslept for 18 months or more and those who coslept for less than 18 months (p < 0.05), as well as between those who coslept for 18 months or more and those who did not cosleep (p < 0.01). In conclusion, breastfeeding at night from 18 months onwards is considered a risk factor for ECC.
Efficacy and Underlying Mechanism of Acupuncture in the Treatment of Posttraumatic Stress Disorder: A Systematic Review of Animal Studies
Authors: Kwon Chan-Young , Lee Boram , Kim Sang-Ho
Published: April 2021

Acupuncture is a nonpharmacological intervention that can be useful in the clinical management of posttraumatic stress disorder (PTSD), especially in situations with a lack of medical resources, including large-scale PTSD events such as disasters. Some clinical studies have reported the clinical effect of acupuncture in improving PTSD symptoms, but the underlying therapeutic mechanism has yet to be explored. Therefore, this review summarized the underlying therapeutic mechanisms of acupuncture in animal PTSD models. A comprehensive search was conducted in 14 electronic databases, and two independent researchers performed study selection, data extraction, and the methodological quality assessment. Twenty-four relevant studies were included in this review and summarized according to the proposed main mechanisms. In behavioral evaluation, acupuncture, including manual acupuncture and electro-acupuncture, reduced anxiety and fear responses and weakened fear conditioning, improved sleep architecture, reduced depressive symptoms, and alleviated disturbance of spatial learning and memory of PTSD animal models. The therapeutic mechanisms of acupuncture proposed in the included studies could be classified into two categories: (1) regulation of stress responses in the neuroendocrine system and (2) promotion of neuroprotection, neurogenesis, and synaptic plasticity in several brain areas. However, the methodological quality of the included animal studies was not high enough to produce robust evidence. In addition, mechanistic studies on specific aspects of acupuncture that may affect PTSD, including expectancy effects, in human PTSD subjects are also needed.
The Effects of Dimethylsulfoxide and Oxygen on DNA Damage Induction and Repair Outcomes for Cells Irradiated by 62 MeV Proton and 3.31 MeV Helium Ions
Authors: Chan Chun-Chieh , Hsiao Ya-Yun
Published: April 2021

Reactive oxygen species (ROS) play an essential role in radiation-induced indirect actions. In terms of DNA damage, double strand breaks (DSBs) have the greatest effects on the repair of DNA damage, cell survival and transformation. This study evaluated the biological effects of the presence of ROS and oxygen on DSB induction and mutation frequency. The relative biological effectiveness (RBE) and oxygen enhancement ratio (OER) of 62 MeV therapeutic proton beams and 3.31 MeV helium ions were calculated using Monte Carlo damage simulation (MCDS) software. Monte Carlo excision repair (MCER) simulations were used to calculate the repair outcomes (mutation frequency). The RBE values of proton beams decreased to 0.75 in the presence of 0.4 M dimethylsulfoxide (DMSO) and then increases to 0.9 in the presence of 2 M DMSO while the RBE values of 3.31 MeV helium ions increased from 2.9 to 5.7 (0–2 M). The mutation frequency of proton beams also decreased from 0.008–0.065 to 0.004–0.034 per cell per Gy by the addition of 2 M DMSO, indicating that ROS affects both DSB induction and repair outcomes. These results show that the combined use of DMSO in normal tissues and an increased dose in tumor regions increases treatment efficiency.
They Talk Muṯumuṯu: Variable Elision of Tense Suffixes in Contemporary Pitjantjatjara
Authors: Wilmoth Sasha , Defina Rebecca , Loakes Debbie
Published: April 2021

Vowel elision is common in Pitjantjatjara and Yankunytjatjara connected speech. It also appears to be a locus of language change, with young people extending elision to new contexts; resulting in a distinctive style of speech which speakers refer to as muṯumuṯu (‘short’ speech). This study examines the productions of utterance-final past tense suffixes /-nu, -ɳu, -ŋu/ by four older and four younger Pitjantjatjara speakers in spontaneous speech. This is a context where elision tends not to be sociolinguistically or perceptually salient. We find extensive variance within and between speakers in the realization of both the vowel and nasal segments. We also find evidence of a change in progress, with a mixed effects model showing that among the older speakers, elision is associated with both the place of articulation of the nasal segment and the metrical structure of the verbal stem, while among the younger speakers, elision is associated with place of articulation but metrical structure plays little role. This is in line with a reanalysis of the conditions for elision by younger speakers based on the variability present in the speech of older people. Such a reanalysis would also account for many of the sociolinguistically marked extended contexts of elision.
Genome-Wide Identification and Expression of Chitinase Class I Genes in Garlic (Allium sativum L.) Cultivars Resistant and Susceptible to Fusarium proliferatum
Authors: Filyushin Mikhail A. , Anisimova Olga K. , Kochieva Elena Z. , Shchennikova Anna V.
Published: April 2021

Vegetables of the Allium genus are prone to infection by Fusarium fungi. Chitinases of the GH19 family are pathogenesis-related proteins inhibiting fungal growth through the hydrolysis of cell wall chitin; however, the information on garlic (Allium sativum L.) chitinases is limited. In the present study, we identified seven class I chitinase genes, AsCHI1–7, in the A. sativum cv. Ershuizao genome, which may have a conserved function in the garlic defense against Fusarium attack. The AsCHI1–7 promoters contained jasmonic acid-, salicylic acid-, gibberellins-, abscisic acid-, auxin-, ethylene-, and stress-responsive elements associated with defense against pathogens. The expression of AsCHI2, AsCHI3, and AsCHI7 genes was constitutive in Fusarium-resistant and -susceptible garlic cultivars and was mostly induced at the early stage of F. proliferatum infection. In roots, AsCHI2 and AsCHI3 mRNA levels were increased in the susceptible and decreased in the resistant cultivar, whereas in cloves, AsCHI7 and AsCHI5 expression was decreased in the susceptible but increased in the resistant plants, suggesting that these genes are involved in the garlic response to Fusarium proliferatum attack. Our results provide insights into the role of chitinases in garlic and may be useful for breeding programs to increase the resistance of Allium crops to Fusarium infections.
REINTEGRACIÓN SOCIAL EN MÉXICO.
Authors: Palomeque-Chable Eduardo
Published: April 2021

El tema de la reinserción social de ex convictos en México describe lo que acontece con este tipo de grupo de personas que al cumplir una condena se reintegran a la sociedad, la intención es buscar mecanismos para tenerlos localizados a través de bases de datos electrónicos, pues en muchas ocasiones se da el caso de que los ex reclusos no pueden encontrar empleos en virtud de ser señalados por la sociedad, es allí la interrogante ¿Cuál es lo labor del Estado para lograr la Reinserción Social de estas personas? pues al fin de cuentas ellos cometieron un ilícito por el cual ya pagaron una condena, por ende al reintegrarse a la sociedad tienen todos sus derechos a salvos, y en caso contrario se estaría violando derechos humanos consagrados en la Constitución Política de los Estados Unidos Mexicanos, además, toma relevancia los Tratados Internaciones que el Estado Mexicano ha suscrito con la intención de regular la materia de reinserción social.
GENERALIDADES DE LOS MECANISMOS ALTERNATIVOS DE SOLUCIÓN DE CONTROVERSIAS
Authors: Castro-Jiménez Verónica
Published: April 2021

El acceso a la justicia es una vía de garantía de este derecho humano a la ciudadanía mediante su administración. En el estado mexicano el artículo 17 Constitucional dispone de mecanismo heterocompositivo (juicio) y autocompositivo (negociación, mediación, conciliación, arbitraje) aplicables en diversas materias y conforme a su normativa. En ese sentido, es importante considerar la profesionalización de los facilitadores a cargo de llevar la gestión de conflictos de mecanismos que requiere considerar ser aplicados desde los principios de los mismos a partir de la justicia alternativa. Aunque hay un avance en la materia este documento expone la justicia alternativa a partir de los mecanismos alternativos en México.
Comparison of growth and developmental stability traits of Japanese quails reared in conventional and enriched cages
Authors: NARİNÇ Doğan , SABUNCUOĞLU Kübra Melis
Published: April 2021

This study was carried out to determine the effects of different rearing systems on some performance and welfare characteristics in Japanese quail. For this purpose, a total of 630 birds were housed in battery-type conventional cages, conventional floor cages and enriched floor cages. There were statistically significant differences between the experimental groups and the sexes in terms of the average body weight of the quails at 42 and 56 days of age (both P<0.01). Accordingly, it was determined that the average body weight of the quails raised in the conventional battery cages were higher than those raised both in the conventional and enriched floor cages. Gompertz growth curve model parameters of β0, β1, β2 were estimated as 262.05, 3.76, 0.050 for birds housed in battery-type conventional cages, 228.12, 3.57, 0.042 for birds housed in conventional floor cages, and 252.53, 3.86, 0.045 for birds housed in enriched floor cages, respectively. Among the bilateral traits, the highest mean value of relative asymmetry was found for wing length of birds reared in conventional battery type cages (P<0.01). As a result, it was determined that quails raised in conventional battery type cages are more advantageous for economic production. However, it may be recommended to use enrichment objects for an animal welfare oriented production system.
Enjeux et résultats de la COP21
Authors: Mayer Benoît
Published: April 2021

La XXIe Conférence des Parties à la Convention Cadre des Nations Unies sur les Changements Climatiques fut, comme annoncé, un événement historique. Il fut marqué par l’adoption de l’Accord de Paris, un traité international qui encadrera les efforts d’atténuation des émissions de gaz à effet de serre à partir de 2020. Le mécanisme mis en place par ce traité est innovant, laissant une grande place aux processus politiques par lesquels les États décideront -ou non -de s’engager à des mesures ambitieuses. Seul l’avenir pourra dire si ce traité rencontrera un plus grand succès que le Protocole de Kyoto.
L’Accord de Paris : fin de la crise du multilatéralisme climatique ou évolution en clair-obscur ?
Authors: Lavallée Sophie , Maljean-Dubois Sandrine
Published: April 2021

Après une décennie de négociations chaotiques, la vingt-et-unième conférence des Parties à la Convention-cadre des Nations Unies sur les changements climatiques est parvenue le 12 décembre 2015 à s’accorder sur le texte d’un traité international, l’Accord de Paris, précédé par une décision qui a pour objet à la fois de l’expliciter et d’en préparer l’entrée en vigueur. Ce texte de compromis représente-t-il une avancée remarquable ou bien ne s’agit-il que d’un accord faible qui ne modifiera pas nos trajectoires d’émissions de gaz à effet de serre à moyen et long terme ? Retracer le processus qui a conduit à son adoption permet de mieux comprendre l’apport substantiel et procédural de cet accord, sans pour autant nier ses limites. En tant que nouvelle construction dans l’édifice complexe qu’est le régime climatique de la CCNUCC, l’Accord de Paris marque davantage le commencement d’une nouvelle ère de diplomatie climatique, pleine d’incertitudes, qu’un aboutissement.