bluuebunny/crossref_metadata_2025 huggingface dataset:
Responses of physiological photosynthetic characteristics of nitrogen fertilizer with organic fertilizer of wheat (Triticum aestivum L.) in response to nitrogen application levels
Authors: NOOR HAFEEZ , Sun Min , Gao Zhiqiang
Published: August 2022

A greenhouse experiment was conducted to understand the responses of the activities of nitrogen consumption is one of the important tools to regulate crop growth and development, and its effect on wheat nitrogen yield is also a hot topic. This study means effects of nitrogen on photosynthetic energy conversion efficiency, and photosynthetic performance of winter wheat. The average Ci, PN, gs and E of hole nitrogen rate were the highest, reaching 4.71 µmol (CO2) mol–1, 20.69 µ mol m–1 s–1 respectively. Thus promoting the synthesis of chlorophyll and improving the SPAD value of flag leaves of winter wheat. The response mechanism of physiological characteristics of high yield capacity provided theoretical basis for further study on the mechanism of high yield of winter wheat. organic manure partial substitution for chemical fertilizer increased post-anthesis N uptake by 81.4 and 16.4% under WS and WW, thus increasing post-anthesis photosynthetic capacity and delaying leaf senescence. Consequently, organic manure partial substitution for chemical fertilizer increased post-anthesis DM accumulation under WS and WW by 51.5 and 29.6%, WUEB by 44.5 and 50.9%, grain number per plant by 11.5 and 12.2% and 1000-grain weight by 7.3 and 3.6%, respectively. The grain yield under organic manure partial substitution for chemical fertilizer treatment increased by 23 and 15%, and water use efficiency (WUEg) by 25 and 23%, respectively. The increased WUE under organic manure partial substitution for chemical fertilizer treatment was due to elevated photosynthesis, decreased Tr and gs and improved transpiration efficiency. Our results suggest that the organic manure partial substitution for chemical fertilizer enabled plants to use water more efficiently under drought stress.
Study on the role and mechanism of HDAC6 in Cd-induced inflammation and fibrosis in mice liver
Authors: Guo Fan , Huang Rongshuang , Huang Zhuo , Zhao Ping , Xu Xiangning , Zhang Weizhen , Lei Ningfei
Published: August 2022

The heavy metal cadmium (Cd) is one of the major environmental pollution toxicants, which is highly toxic to the environment and can cause damages to many organs after entering human body. Studies have shown that Cd pollution is characterized by long-cycle and insidiousness, and long-term Cd exposure can lead to liver fibrosis, but the mechanism remains unclear. This study employed a Cd-induced liver fibrosis mouse model to investigate the health effects for toxic of Cd exposure by oral administration on inflammation and fibrosis of liver, and to further explore the role and mechanism of histone deacetylase 6 (HDAC6) in this model. Results showed that the Cd exposure induced inflammation and fibrosis of mice liver in a dose-dependent manner. Based on Western blotting and immunofluorescence analysis, we found that HDAC6 was involved in Cd-induced liver inflammation and fibrosis. Inhibition of HDAC6 attenuated Cd-induced inflammation and fibrosis probably by regulating endoplasmic reticulum (ER) stress. Our findings provide new insights into the health effects for the liver damage induced by Cd exposure, highlighting that HDAC6 may be a potential target for therapy against Cd-induced inflammation and fibrosis in liver.
Investigation on the use of Ensemble Learning and Big Data in Crop Identification
Authors: Ahmed Sayed , Mahmoud Amira S. , Farg Eslam , Mohamed Amany M. , Moustafa Marwa S. , AbdelRahman Mohamed A.E. , AbdelSalam Hisham M. , Arafat Sayed M
Published: August 2022

The agriculture sector in Egypt faces several problems, such as climate change, water storage, and yield variability. The comprehensive capabilities of Big Data (BD) can help in tackling the uncertainty of food supply occurs due to several factors such as soil erosion, water pollution, climate change, socio-cultural growth, governmental regulations, and market fluctuations. Crop identification and monitoring plays a vital role in precision agriculture. Although several machine learning models have been utilized in identifying crops, the performance of ensemble learning has not been investigated extensively. The massive volume of satellite imageries has been established as a big data problem forcing to deploy the proposed solution using big data technologies to manage, store, analyze, and visualize satellite data. In this paper, we have developed weighted voting mechanism for improving crop classification performance in a large scale, based on ensemble learning and big data schema. Based on Apache Spark, the popular DB Framework, the proposed approach was tested on El Salheya, Ismaili governate. Our findings confirm the generalization of the proposed crop identification approach at a large-scale setting.
Transnasal endoscopic surgery with the common choanal approach for acquired choanal stenosis and atresia after radiotherapy
Authors: zheng chaopan , Han Ling , Mai Jiahao , Zhang Wei
Published: August 2022

Objectives
To assess retrospectively the effectiveness and safety of transnasal endoscopic surgery (TES) with the common choanal approach for treatment of iatrogenic choanal stenosis and atresia (CSA) acquired after radiotherapy in patients with nasopharyngeal carcinoma.
Methods
32 patients with unilateral or bilateral post-radio therapy CSA were consecutively hospitalized for elective TES with the common choanal approach. For further enlargement of the neochoana, the accurately dissecting approach including the resection of the posterior septum 1cm or more anterior to the stenosis and reconstruction of the posterior part of the inferior turbinate at least 0.5 cm distant from the septum. All procedures provide the neochoana with enough adequate size and preservation of mucosa. Nasal obstruction and rhinorrhea were evaluated using a visual analog scale before and at least 3 months after surgery.
Results
TES with the common choanal approach was successfully and uneventfully completed in all patients. Nasal obstruction and rhinorrhea significantly were alleviated after surgery, from the baseline. Follow-up transnasal endoscopy revealed a patent nasal airway aperture in all patients.
Conclusions
TES with the common choanal approach was effective and safe for treatment of post-radiotherapy CSA.
The Sensitivity and Specificity Comparison Between Stool Wet Mount and Kato-katz Techniques for the Detection of Intestinal Helminthes
Authors: Wolde Amsalu Mekonnen
Published: August 2022

BackgroundIn this prevalence study, the efficiency and sensitivity of stool wet mount and Kato-Katz smear techniques for the diagnosis of intestinal helminthes were compared to detect human intestinal helminths.ObjectiveTo assess the sensitivity and specificity between stool wet mount and Kato-Katz TechniquesMethodologyA total of 200 stool specimens were collected from school children aged 6 to 16 from four primary schools randomly selected in Badessa woreda, west Hararghe zone, eastern Ethiopia. Each specimen was smeared on one slide for every technique with normal saline for wet mount and a cellophane cover for Kato-Katz technique. The overall prevalence of the parasites in each school of the woreda was determined.ResultThe overall sensitivity of both techniques was calculated. Finally, the evaluation of sensitivity and specificity of both techniques was interpreted as Kato-Katz technique is more effective and sensitive than the stool wet mount technique.ConclusionTo detect intestinal helminths especially from carriers and non-symptomatic patients Kato-Katz technique is a selective and sensitive method.
Paradoxes of breast cancer incidence and mortality in two corners of Europe
Authors: Roginski Mikaela , Sifaki-Pistolla Dimitra , Stomby Andreas , Velivasaki Georgia , Faresjö Tomas , Lionis Christos , Faresjö Åshild
Published: August 2022

Background
Breast cancer incidence is rising globally. Mortality rates show a heterogenous pattern, where geographical disparities might indicate influence of health policy, behavior and care provision. Early detection and treatment have been proven to have a profound impact on prognosis.
Methods
Breast cancer data from Sweden and Crete was derived from registries. Incidence and mortality were expressed as Age-Standardized Incidence Rates (ASIR), Age-Standardized Mortality Rates (ASMR) and survival as intervals of three consecutive enrolling years.
Findings
Incidence of breast cancer has for decades risen in Sweden and also on Crete. In 2019, ASIR was 217.5 in Sweden and 58.9 on Crete, (p < 0.001). Mortality rates, however, showed opposite trends. ASMR was higher on Crete (25/100.000 person years) than in Sweden (17/100.000 person years) (p = 0.04). ASMR has fallen in Sweden from 25.5 to 16.8 in the period 2005–2019, while on Crete, ASMR continued to rise from 22.1 to 25.3. Since the early 1980’s, a successive rise in survival rate in Sweden was seen with a 5-year survival rate of 92% since 2015, but a converse development on Crete with 85% 5-year survival rate during the same period.
Interpretation
Breast cancer incidence is slowly rising in both studied regions, but the mortality increase on Crete in contrast to Sweden where mortality decrease. The findings reveal an improvement of the survival rate for Swedish breast cancer patients, while survival trends on Crete is falling. This may be related to the national breast screening program established in Sweden, but not in Greece.
Integrated immune-related gene signature predicts clinical outcome for patients with Luminal B breast cancer
Authors: Xie Zhen , Cai Du , Ye Runyi , Shan Zhen , Lin Ying , Gao Feng , Shao Nan , Kuang Xiaying
Published: August 2022

Background
Luminal B breast cancer is routinely treated with chemotherapy and endocrine therapy. However, its sensitivity to treatment remains heterogeneous; therefore, identifying patients who may most benefit, remains crucial. Immune-related genes are reportedly related to the prognosis of breast cancer. The purpose of this study was to evaluate the impact of an immune-related gene signature (IRGS) in predicting the prognosis of patients with Luminal B breast cancer.
Methods
We selected patients with Luminal B breast cancer from two large datasets: 488 from the Metabric dataset (training cohort) and 250 patients from the cancer genome atlas (TCGA) dataset (validation cohort). Prognostic analysis was performed to test the predictive value of IRGS, and enrichment analysis and ESTIMATE (Estimation of Stromal and Immune cells in Malignant Tumor tissues using Expression data) were used for deeper function analysis.
Results
A prognostic IRGS model containing 12 immune-related genes was developed. After which, we separated patients with Luminal B breast cancer into low-risk and high-risk groups in terms of disease-free survival (DFS) (P < 0.001). Multivariate analysis identified IRGS as an independent prognostic factor. Furthermore, functional analysis showed that the 12 genes were mainly enriched in pathways related to chemotherapy response, whose expression levels showed completely opposing trends in low-risk and high-risk groups.
Conclusions
The novel IRGS is a satisfactory and reliable biomarker to predict the clinical outcome of patients with Luminal B breast cancer which potentially facilitating individualised management. Further studies are needed to assess the clinical potential in predicting prognosis and the treatment options for Luminal B breast cancer patients.
Enhanced oxidative phosphorylation in Retinoblastoma tumors is dependent on depleted Hexokinase1 and lack of AMPKα activation
Authors: Babu Vishnu Suresh , Mallipatna Ashwin , S.A Deepak , Dudeja Gagan , Kannan Ramaraj , Shetty Rohit , Nair Archana , Gundimeda Seetharamanjaneyulu , Tun Sai Bo Bo , Ho Candice Ee Hua , Chaurasia Shyam , Bhattacharya Shomi , Verma Navin , Rajamani Laxminarayanan , Guha Nilanjan , Heymans Stephane , Veluchamy Amutha Barathi , Ghosh Arkasubhra
Published: August 2022

Lack of retinoblastoma protein (Rb) causes aggressive intraocular retinal tumors in children. Recently, Rb tumors have been shown to have a distinctly altered metabolic phenotype, such as reduced expression of glycolytic pathway proteins alongside altered pyruvate and fatty acid levels. In this study, we demonstrate that loss of Hexokinase 1(HK1) in tumor cells rewires their metabolism allowing enhanced oxidative phosphorylation-dependent energy production. We show that rescuing HK1 or RB1 in these retinoblastoma cells reduced cancer hallmarks such as proliferation, invasion, spheroid formation and increased their sensitivity to chemotherapy drugs. Induction of HK1 was accompanied by a metabolic shift of the cells to glycolysis and a reduction in mitochondrial mass. Cytoplasmic HK1 bound Liver Kinase B1 (LKB1) and phosphorylated AMP-activated kinase-α (AMPKα Thr172), thereby reducing mitochondria-dependent energy production. We validated these findings in tumor samples from Rb patients compared to age-matched healthy retina. HK1 or RB1 expression in Rb-/- cells led to reduction in their respiratory capacity and glycolytic proton flux. HK1 overexpression reduced tumor burden in an intraocular tumor xenograft model. AMPKα activation by AICAR also enhanced the tumoricidal effects of chemotherapeutic drug topotecan in vivo. Therefore, enhancing HK1 or AMPKα activity can reprogram cancer metabolism and sensitize retinoblastoma tumors to lower doses of existing treatments, a potential therapeutic modality for retinoblastoma.
Single-cell analysis reveals the COL11A1+ fibroblasts are cancer-specific fibroblasts that promote tumor progression
Authors: Zhang Jiayu , Lu Shiqi , Lu Tong , Han Donghui , Zhang Keying , Gan Lunbiao , Wu Xinjie , Li Yu , Zhao Xiaolong , Li Zhengxuan , Shen Yajie , Hu Sijun , Yang Fa , Wen Weihong , Qin Weijun
Published: August 2022

Background
Cancer-associated fibroblasts (CAFs) promote tumor progression through extracellular matrix (ECM) remodeling and extensive communication with other cell types in the tumor microenvironment. However, most CAF-targeting strategies have failed in clinical trials due to the heterogeneity of CAFs. Hence, we aimed to identify the tumor-promoting CAFs and determine their specific membrane molecules to ensure precise targeting.
Methods
We integrated multiple single-cell RNA sequencing (scRNA-seq) datasets across different tumors and adjacent normal tissues to identify the tumor-promoting CAF subtype. We tried to analyze the origin of these tumor-promoting CAFs, and we also performed a cell-type deconvolution analysis to examine the association between the tumor-promoting CAF subtype and prognosis in TCGA cancer cohorts.
Results
We found that COL11A1+ fibroblasts represent a novel CAF subtype that only exist in tumor tissues but not in normal tissues and named them cancer-specific fibroblasts (CSFs). By using pseudotime analysis, we revealed that these CSFs were transformed from normal fibroblasts. CSFs represent a more activated CAF subtype and may promote tumor progression by regulating ECM remodeling and inhibiting antitumor immune responses. We also identified that CSFs specifically express the surface molecules LRRC15, ITGA11, SPHK1 and FAP, which could distinguish CSFs from other fibroblasts.
Conclusions
We identified COL11A1+ fibroblasts as a novel subtype of CAFs that specifically exist in tumor tissues and named them CSFs. These CSFs specifically express LRRC15, ITGA11, SPHK1 and FAP, which could be used as therapeutic targets for cancer treatment.
How, where and when to screen for porcine cytomegalovirus (PCMV) in donor pigs for xenotransplantation
Authors: Halecker Sabrina , Hansen Sabrina , Krabben Ludwig , Ebner Friederike , Kaufer Benedikt , Denner Joachim
Published: August 2022

Porcine cytomegalovirus (PCMV) that is actually a porcine roseolovirus (PRV) is a common herpesvirus in domestic pigs and wild boars. In xenotransplantation, PCMV/PRV has been shown to significantly reduce the survival time of pig kidneys and hearts in preclinical trials with different non-human primates. Furthermore, PCMV/PRV has been transmitted in the first pig to human heart xenotransplantation and contributed to the death of the patient. Although transmitted to the recipient, there is no evidence that PCMV/PRV can infect primate cells including human cells. Since PCMV/PRV is a roseolovirus closely related to the human herpesviruses 6 and 7, antiviral drugs against human CMV are not effective. However, there are well described strategies to eliminate the virus from pig facilities. In order to detect the virus and to eliminate it, highly sensitive detection methods and the knowledge, how, where and when to screen the donor pigs is required. Here, a comparative testing of different organs from pigs of different age using PCR-based and immunological methods was performed. Testing young piglets, PCMV/PRV was well detected by PCR in blood, bronchoalveolar lavage fluid, tonsils and heart. In adult animals, detection by PCR was in most cases not successful, because the virus was in latency. Therefore, detection of antibodies against selected recombinant proteins corresponding to epitopes detected by nearly all infected animals in a Western blot assays is advantageous. Immunological testing on the other hand is not beneficial in young animals. Piglets might have PCMV/PRV-specific antibodies that they obtained from the infected mother by the colostrum. Using a thoughtful combination of PCR-based and immunological methods, detection of PCMV/PRV in donor pigs for xenotransplantation is feasible and a controlled elimination of the virus by early weaning or other methods is possible.
Postoperative course of acute traumatic conus medullaris injury
with complete injury
Authors: Morishita Yuichiro , Sasaki Sota , Kawano Osamu , Yamamoto Takuaki , Maeda Takeshi
Published: August 2022

Study design: Retrospective clinical study.Objectives: To evaluate annual changes in the pathology of conus medullaris injury (CMI) and investigate its precise pathophysiology.Setting: Hospital in Iizuka, Japan.Methods: From January 2012 to January 2020, 16 individuals with complete spinal cord injury caused by vertebral fracture at the level of T12 or L1 were included in this study. We collected American Spinal Injury Association Impairment Scale (AIS), Lower-Extremity Motor Score (LEMS), and modified Frankel classification (mFr) data at admission and at 24 months postoperatively. Results: At the final evaluation, 3 of the 16 participants (18.75%) showed neurological improvement from AIS A to AIS C or D. Furthermore, LEMS significantly improved during the postoperative 24 months (p < 0.05). In the mFr, 12 of the 16 participants (75.0%) showed improvement. Moreover, three individuals (18.75%) acquired independent walking ability (higher than mFr D3) at 24 months postoperatively.Conclusion: Even in cases of complete CMI only, the recovery of lower extremity muscle strength varies among individuals.
A case-study on effects of Bariatric Surgery for early-onset and adult-onset patients with obesity in a single center-Sri Lanka
Authors: Abeysinghe Ganindu Kalpa , Wijeratne Thejana Kamil , Wijetunga Lahiru , Wijetunga Udai , Abeyratne Dilini , Kariyawasam Maneesh
Published: August 2022

Background
Bariatric surgery focuses on patients with diverse health complications, varying onset of obesity and total duration of obesity. Sri Lanka characterizes an escalation of morbid obesity which had transformed into a significant public health concern. Therefore, objective of this study is to explore the metabolic parameters and health complication relationships of between early onset and adult-onset patients with obesity.
Objective
It has been shown that Bariatric Surgery is a better candidate for weight reduction for morbidly obese patients worldwide. Our goal is to investigate whether the similar principal would work out for bariatric surgery on morbidly obese patients in Sri Lanka.
Methods
A total of 110 unrelated patients from Colombo South Teaching Hospital, Sri Lanka were included into this study. The body fat parameters were measured to analyze percentage rate of weight loss and Body mass index (BMI) of patients prior to bariatric surgery and 9 months post operational. Patients were categorized into early-onset obese (< 18 years of age) and adult onset obese (> 18 years of age).
Results
Adult-onset patients with obesity had a higher body weight and body mass index compared to early-onset patients with obesity. Post-operational 9-month records indicate mean weight and BMI of early onset patients with obesity reduced by 33.03 kg and 12.88 kgm-2 (p < 0.001) respectively. Similarly, adult-onset obese patients reduced weight and BMI by 27.63 kg and 11.34 kgm-2 (p < 0.001) respectively.
Conclusion
Rate of reduction of mean weight and BMI of early-onset patients with obesity were comparatively higher than the adult-onset patients with obesity.
Deep Learning applied for Spectrum Sensing using multiple and concurrent stages
Authors: Ouamna Hamza , Madini Zhour , Zouine Younes
Published: August 2022

Spectrum sensing techniques have many challenges and as one as the most challenges are the noise and interference rejection. Since the occurrence of noise power uncertainty cause the degradation of the performance of the spectrum detector. One of the most techniques of spectrum sensing is the Energy Level detection it could be used with deep learning network to distinguish between presence of signal and noise to this end, we will introduce a comparison between AlexNet, SqueezeNet ResNet101 and LSTM neural networks. To test them in different situations. . ...
A Hosting and Sharing Method as an Alternative to MATLAB Web App
Authors: Ren Ruijie , Sun Xiang-e , Hu Lin
Published: August 2022

Currently, using MATLAB Web App Server to deploy MATLAB Web applications for hosting and sharing interactive Web applications involves the following problems: slow loading of applications, incompatibility with some browser versions, and various shortcomings of deployment tools, such as poor scalability and difficulty in optimizing black boxes. These problems adversely affect the user experience. To address this situation, we propose the use of front-end technology to design application layouts and build an application hosting platform with front-end and back-end separation using Nginx and Python. This method is shown to be simple and efficient, and it can successfully overcome the aforementioned problems while providing new ideas for hosting and sharing.
The influence of social participation on the health of empty nesters in China
Authors: luo wei , cheng peng
Published: August 2022

In the dual context of healthy aging and active aging, the article uses research data from the 2018 China Health and Aging Tracking Survey (CHARLS) to analyze the effects of different types of social participation on the health of empty nesters based on activity theory. The findings show that economic participation, social participation and family participation have significant effects on the health of empty nesters, but voluntary participation has no significant effects; there is variability in social participation on health under different dimensions, and social participation has more significant effects on the physical health of empty nesters. The above results remain robust after applying the instrumental variables approach to address endogeneity, which suggests that activity theory in enhancing the health of empty nesters through social participation can help to actively address the challenges of aging. Based on this, the article suggests the need to create a favorable social atmosphere for social participation of empty nesters, strengthen institutional construction, and provide strong legal protection; children should take the initiative to create conditions for their parents' social participation; and empty nesters should use their own work and participation abilities to partially or fully solve their health problems through their own behaviors.
The association between Dietary Inflammatory Index and hyperuricemia: NHANES 2007–2016
Authors: Chen Yiqiu , Han Ting
Published: August 2022

Background: The impact of the potential inflammatory effect of diet on hyperuricemia has not been adequately investigated. The aim of our study was to evaluate the association of Dietary Inflammatory Index (DII) on hyperuricemia in American adults.Methods: We conducted a cross-section study using the public database of the National Health and Nutrition Examination Survey (NHANES), 2007-2016. The dietary inflammatory index (DII) score was based on dietary recall interviews. The relationship between DII score and hyperuricemia was evaluated by multivariable adjusted logistic regression models and stratification analyses by potential confounders.Results: A total of 18,282 participants were eligible for this study. Multivariable logistic regression models suggested that hyperuricemia is independently correlated with DII scores. Compared to the lowest quartile of DII scores, the odds ratio (OR) for participants in the third and fourth quartile were 1.50 (95%CI: 1.26-2.78), 1.45 (95%CI: 1.25-1.68) for hyperuricemia (P-trend < 0.0001). Subgroup analysis showed that the association between the dietary inflammatory index and hyperuricemia was statistically significant in age groups, sex groups, white and black race, overweight subjects, marital status groups, PIR groups, none and ex-smokers, diabetes groups and hypertension groups.Conclusion: The results provide evidence of a positive association between DII score and hyperuricemia in American adults.
Further study on domains and quasihyperbolic distances
Authors: Ding Shusen , Helliwell Dylan , Pandya Gavin , Yae Arya
Published: August 2022

We establish constructive geometric tools for determining when a domain is Ls- averaging and obtain upper and lower bounds for the Ls- integrals of the quasihyperbolic distance. We also construct examples which are helpful to understand our geometric tools and the relationship between p-Poincare domains and Ls- averaging domains. Finally, finite unions of Ls(μ)-averaging domains are explored.
Transcriptome and proteome analyses reveal high nitrate or ammonium applications alleviate photosynthetic decline of Phoebe bournei seedlings under elevated carbon dioxide by regulating glnA and rbcS
Authors: Wang Xiao , Wei Xiaoli , Wu Gaoyin , Chen Shengqun
Published: August 2022

Background
Phoebe bournei (Hemsl.) Y.C. Yang is a precious timber species and is listed as a national secondary protection plant in China. P. bournei seedlings show obvious photosynthetic decline when grown long-term under an elevated CO2 concentration (eCO2). This decline can be alleviated by high nitrate or ammonium applications. However, the underlying mechanisms of photosynthetic decline and the regulation of photosynthesis by nitrogen under eCO2 have not yet been elucidated.
Results
We performed transcriptomic and proteomic analyses of P. bournei of seedlings grown under an ambient CO2 (AC) concentration (350 ± 70µmol·mol− 1) and applied with either a moderate level of nitrate(0.8 g per seedling, N), a high level of nitrate (1.2 g per seedling, hN), or a moderate level of ammonium (0.8 g per seedling, A) and compared them with those of seedlings grown under an elevated CO2 (EC) concentration (700 ± 10µmol·mol− 1,i.e., AC_N vs EC_N, AC_hN vs EC_hN, AC_A vs EC_A) to identify differentially expressed genes (DEGs) and differentially expressed genes (DEGs). We identified 4528 (AC_N vs EC_N), 1378 (AC_hN vs EC_hN), and 252 (AC_A vs EC_A) DEGs and 230, 514, and 234 DEPs, respectively, of which 59 specific genes and 21 specific proteins were related to the regulation of photosynthesis by nitrogen under eCO2. A combined transcriptomic and proteomic analysis identified 7 correlation-DEGs-DEPs (cor-DEGs-DEPs) genes. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses of these cor-DEGs-DEPs genes revealed crucial pathways involved in glyoxylate and dicarboxylate metabolism and nitrogen metabolism. The rbcS and glnA cor-DEGs-DEPs genes were enriched in these two metabolisms. We propose that the rbcS and glnA cor-DEGs-DEPs genes play an important role in photosynthetic decline and nitrogen regulation.
Conclusions
Transcriptomic and proteomic profiles of P. bournei were used to evaluate elevated CO2 effects on photosynthesis and nitrogen regulation. The elevated CO2 triggered the downregulation of glnA and RbcS, thus causing photosynthetic decline. High nitrate or ammonium applications alleviated the downregulation of glnA and rbcS and, hence, alleviated photosynthetic decline.
Use of an innovative cuff pressure control and subglottic secretions drainage system in COVID-19 ARDS patients undergoing pronation
Authors: Tanzarella Eloisa Sofia , Lombardi Gianmarco , Baroni Silvia , Sarlo Francesca , Cutuli Salvatore Lucio , Carelli Simone , Cesarano Melania , Gennenzi Veronica , Pintaudi Gabriele , Vargas Joel , Dell’Anna Antonio Maria , Grieco Domenico Luca , Urbani Andrea , Antonelli Massimo , De Pascale Gennaro
Published: August 2022

Anapnoguard endotracheal tubes and control unit were used in 15 patients with COVID-19 acute respiratory distress syndrome. Anapnoguard system provides suction, venting, rinsing of subglottic space and controls cuff pressure detecting air leakage through the cuff. Alpha-amylase and pepsin levels, as oropharyngeal and gastric microaspiration markers, were detected from 85 tracheal aspirates.Oropharyngeal microaspiration occurred in 47 cases (55%). Episodes of gastric microaspiration weren’t detected. There wasn’t correlation in enzyme levels between prone and supine positioning. Ventilator-associated pneumonia (VAP) rate was 40%. The use of the AG system provided effective Pcuff control and SS drainage. Nevertheless, the role of Anapnoguard system in VAP prevention is worthy to be further investigated.
CHARACTERIZATION OF DIFFERENT TYPES OF ISOLATED LIGINS FROM INDUSTRIAL WASTE AND THEIR POTENTIAL USE CALORIFIC
Authors: Pompêu Gabriela Ciribelli Santos , Borges Mariana Fornazier , Otaguro Harumi , de Morais Luís Carlos , Pasquini Daniel , Ruggiero Reinaldo
Published: August 2022

One of the advances of new technologies applied in biorefineries is focused on the valorization of lignin for the production of bioenergy and on the development of new products. The article aims to analyze and characterize different types of lignins isolated from four Brazilian agro-industrial residues: sugarcane bagasse, black liquor from cellulosic pulp, mango seed and pineapple peel. As a main focus, we approach the thermal and structural characterization of the samples, through the analysis of energy content, TGA, DSC, UV-Vis, SEM, FT-IR and elemental analysis. All of them had high potential for calorific and energy use, considering their high content of SCP and carbon in their compositions, which increases the profitability of bioenergy production. But, in particular, we highlight the lignin isolated from sugarcane bagasse and eucalyptus for its wide availability as industrial waste, easy access for use and large number of unused waste content and inappropriate disposal, suggesting further studies for their applications.
Modulating the Supramolecular Helicity of Poly(m-phenylenediamine) by Achiral Monomer Copolymerization
Authors: Zha Xinlin , Xu Guilin , Xiong Yi , Yan Zhong , Liu Ke , Li Mufang , Chen Yuanli , Lu Jing , Wang Dong
Published: August 2022

Designing artificial systems to mimic chiral superstructures and exploring how achiral molecules precisely modulate their chirality are crucial to understand the origin of homochirality in nature. Herein, we report that when using conventional supramolecular transcription methods to prepare chiral poly(m-phenylenediamine), simply introducing various small amounts of achiral diaminopyridines (DAPs) to copolymerize with m-phenylenediamine (MPD) enables the resulting chiral copolymers with adjustable helical configurations and chiroptical activities in an enantiopure template system. The strong hydrogen bonds between DAPs and the template molecules (L/D-PhgC16) proved to be the driving-force for guiding the chiral polymerization mode of MPD. Impressively, the exquisite self-sorting phenomenon is observed by tuning the stoichiometric ratio of DAP and D-PhgC16, where the as-prepared copolymers with opposite helicity can exist simultaneously to form a double network structure and their chiroptical activity could be well regulated. Furthermore, based on such a copolymerization strategy, we have built a conceptual library of helical functional copolymers with editable polymer types including conducting polymers and designable amine-aldehyde condensation-based polymers. This copolymerization-mediated synthetic protocol may facilitate the development of chiral polymers with controlled morphologies and dynamic compositions.
Anxiety and Depressive Symptoms Developed During COVID-19 and Their Impact on the Academic Performance of Egyptian College Students
Authors: Rageh Omar El Sayed , Allah Meret Tawfik Awad , Abozekry Mennatullah Mohammed Abd el Nasser , Atlam Salwa Hassan
Published: August 2022

Introduction: The COVID-19 pandemic has increased levels of anxiety and depression among the public; however, the impact on the faculty of medicine students in Egypt with respect to academic achievement has not been well-documented.Objective: Assessment of the prevalence of depression and anxiety among medical college students in Egypt during COVID-19 pandemic and impact thereof on their academic achievement.Participants: 396 college students participated in this study and filled the questionnaire representing Egypt governates.Methodology:An online survey was conducted via Google Forms addressing undergraduate students of all medical fields belonging to all Egyptian universities. A previously validated questionnaire sheet containing standardized scale for anxiety and depression, named Hospital Anxiety and Depression Scale (HADS) form is used in this study.Results and Conclusion: Among the 396 participants, 28.5% experience symptoms of anxiety, and 35.6% are considered to have developed anxiety disorder. With respect to depressive symptoms, 21.2% are borderline and 38.1% experience actual depressive symptoms. However, there has been no significant association between these mental health issues and academic achievement. Families with sufficient savings and income as well as male students have fallen among the protective factors. High prevalence of depressive symptoms and anxiety among medical students during COVID 19 pandemic is alarming. Evidently, there is no significant impact on students’ academic performance; nevertheless, further studies are required to detect the long-term impact of this pandemic on student performance.
Thermal Conductivity and Phase Change Properties of Boron Nitride-Lead Oxide Nanoparticles doped Polymer Nanocomposites
Authors: Cinan Zehra Merve , Baskan Taylan , Erol Burcu , Mutlu Saliha , Ortaç Bülend , Yilmaz Sevil Savaskan , Yilmaz Ahmet Hakan
Published: August 2022

The thermally conductive phase change materials (PCMs) were produced using the crosslinked Poly (Styrene-block-Ethylene Glycol Di Methyl Methacrylate) (PS-PEG DM) copolymer by employing the boron nitride (BN)/lead oxide (PbO) nanoparticles. DSC and TGA methods were used to research the phase transition temperatures (melting and crystallization temperatures: Tm and Tc), the phase change enthalpies (melting and crystallization enthalpies: ∆Hm and ∆Hc). The thermal conductivities (λ) of the PS-PEG/BN/PbO PCM nanocomposites were investigated. The ∆Hm and λ value of PS-PEG/BN/PbO PCM nanocomposite containing BN 13 wt%, PbO 60.90 wt%, and PS-PEG 26.10 wt% was determined to be 27.6 Jg− 1 and 18.874 W/(mK). From DSC measurements, Tm and Tc of PS-PEG PCM nanocomposites were found to vary between 57.8°C-205°C, 4.7°C-188.6°C, respectively. The crystallization fraction (Fc) values of PS-PEG (1000) and PS-PEG (1500) copolymers are 0.032–0.034; 0.063, respectively. XRD results of the polymers, the PCM nanocomposites showed that the sharp diffraction peaks at 17.00° and 25.28° of PS-PEG copolymer belonged to the PEG part. When nanoparticles were added to the polymers, SEM and TEM images confirmed that the PCM nanocomposites have a grain, spherical shape, and homogeneous distribution of the nanoparticles. Since these new nanocomposites, whose successful results we have presented as radiation shields in another study, show remarkable thermal conductivity performance, they can be used as conductive polymer nanocomposites for effective heat dissipation in heat exchangers, power electronics, electric motors, generators, communication, and lighting equipment. At the same time, according to our results, PCM nanocomposites can be considered as heat storage materials in the energy storage system.
Efficacy and Safety of Endovascular Therapy for 34 cases of Progressive Ischemic Stroke in Posterior Circulation with Large Artery Stenosis/Occlusion
Authors: Li Dandan , Chen Yang , Luo Xin , Cheng Zhijuan , Lei Keqi , Chen Weiping , Yin Min , Li Fang , Wang Kai , Tu Jianglong
Published: August 2022

It is unclear whether endovascular therapy (ET) can improve the prognosis of posterior circulation progressive ischemic stroke (PIS) due to large vessel stenosis/occlusion. The purpose of this study was to evaluate the efficacy and safety of ET for patients with PIS in posterior circulation who were selected based on ischemic penumbra detected on brain imaging. According to inclusion and exclusion criteria, patients with posterior circulation PIS hospitalized in the Second Affiliated Hospital of Nanchang University from May 2020 to December 2021 were retrospectively included and divided into ET + standard medical therapy (SMT) and SMT according to actual treatment conditions. Our research shows that ET is more effective than conservative therapy of Progressive Ischemic Stroke in Posterior Circulation with Large Artery Stenosis/Occlusion. In those patients with high NIHSS scores, ET had better neurological function recovery than conservative treatment. Delayed recanalization still has better therapeutic effect.
The role of cannulated compression screws in the treatment of nontraumatic necrosis of the femoral head with allogeneic fibular graft: a biomechanical analysis
Authors: Lai Bin , Cai Miaoxin , Bai Guowen , Wang Shaoyu , Pang Zhihui
Published: August 2022

Purpose
To explore the biomechanical effect and mechanism of cannulated compression screw in the treatment of non traumatic necrosis of femoral head with allogeneic fibula graft.
Methods
Based on the CT data of healthy adults, four groups of models were established by using finite element software: the normal group, the femoral head necrosis group, the hip preservation operation group with allogeneic fibula graft (later referred to as group A), and the hollow compression screw combined with allogeneic fibula graft (later referred to as group B). Apply 1440N, 2400N and 4200N loads to the four groups of models respectively, observe the changes of stress distribution on the surface and deep of the femoral head, internal mechanical transmission pathway in different groups under different loads, as well as the displacement of implants in the two groups of surgical models, and explore the biomechanical role and mechanism of hollow compression screws in the same kind of allogeneic fibula graft.
Results
(1) Under normal circumstances, the pressure of the femoral head surface and internal cancellous bone is mainly concentrated in the anterolateral weight-bearing area of the femoral head, and the internal stress can be well transmitted to the lower limbs through the femoral calcar, femoral neck and other parts, without obvious stress conduction barrier.(2) The closer the necrotic location is to the anterolateral column of the weight-bearing area, the stress peaks of the cartilage, cortical bone and cancellous bone on the surface of the femoral head increase significantly compared with the normal model. With the increase of load, the stress peaks of the above bones increase significantly. In type C1 and C2 necrosis, the stress transmission of femoral head and neck was abnormal, and the stress concentration occurred in the normal bone around the necrotic area.(3) Under different loads, the peak value of von Mises stress in type C1 necrotic area in group B decreased by 1.67mpa (-18.45%), 2.77mpa (-18.37%), 4.84mpa (-18.35%) respectively compared with group A. the peak value of von Mises stress in type C2 necrotic area in group B decreased by 0.05Mpa (-0.58%), 0.08mpa (-0.56%), 0.15Mpa (-0.6%) respectively compared with group A; At the same time, under different loads, the displacement distance of type C1 allogeneic fibula strips in group B decreased by 0.06mm (-8.7%), 0.1mm (-8.7%) and 0.17mm (-8.42%) respectively compared with group A. the displacement distance of type C2 allogeneic fibula strips in group B decreased by 0.01mm (-1.72%), 0.01mm (-1.03%) and 0.02mm (-1.19%) respectively compared with group A.
Conclusion
In the allogeneic fibula graft surgery, the addition of cannulated screws may have a better mechanical effect of dispersing the stress in the necrotic area and stabilizing the fibula strip, which is most significant in type C1 necrosis.
Infants’ Nutrition in Polygynous Family Structure: Evidence from SSA Countries
Authors: Efobi Uchenna
Published: August 2022

Considering the mounting interest concerning the effect of family structures on child wellbeing, the present paper investigates whether polygyny affects a child’s nutrition in Africa. To this end, I utilize nationally representative data from twenty-seven SSA countries for the periods 2010 to 2020 to examine the effects of polygynous household structure on a broad set of indicators of child nutrition intake, including dietary diversity and specific micronutrient intake. By relying on the gender of the first and second child of the first wife, I attempt to control for the endogeneity of polygyny in the estimation. The empirical results consistently indicate less dietary intake of the child in such a household. The effect is seemingly driven by the level of education of the mother and within-household social interaction. Some of the adverse effects of polygyny are only seen for the child in poorer homes. Suggesting both economic and normative channels as the plausible mechanism through which polygyny affects a child’s nutritional quality.
Improving Rotational Partners: intraspecies variation for pea cover cropping traits
Authors: Marques Edward , Kerwien Lauren , Bueno Erika , BishopvonWettberg Eric J
Published: August 2022

Purpose: To improve cover crops as rotational partners, intraspecies variation for cover cropping traits such as nutrient mobilization, carbon deposition, and beneficial microbial recruitment must be identified. The majority of research on cover crops has focused on interspecies comparisons for cover cropping variation with minimal research investigating intraspecies variation. Methods: To address if variation of cover cropping traits is present within a cover cropping species, we grew 15 diverse accessions (four modern cultivars, three landraces, eight wild accessions) of pea in an organic setting. We measured various cover cropping traits such as nutrient mobilization, soil organic matter deposition, microbial recruitment, and quantified the effect of pea accession on the growth and yield of a subsequently planted corn crop. Results: We found that domestication history and genotype of pea had a significant effect on soil properties: C%, N%, manganese, magnesium, sodium, calcium, and effective CEC, and the yield of the subsequent corn crop. Additionally, no variation for prokaryotic recruitment (alpha and beta diversity) was observed within pea, however we did observe significant variation for fungal recruitment (alpha and beta diversity) due to domestication and accession. In conclusion, our results revealed the presence of intraspecies variation for cover cropping traits which, may have impacted the rotational values of pea accessions. Conclusions: Our results demonstrate that cover crops can be improved as rotational partners to ultimately boost crop yields in sustainable agroecosystems.
Construction and Satisfaction survey of an information management platform and assessment of satisfaction levels among information platform for caregivers of inpatients in a Chinese hospital
Authors: Gu Ruting , Shan Xinzhi , Liu Xiaomin , Lu Xiaohong , Yang Jieting , Zhang Xinwei , Wei Lili
Published: August 2022

Aim
To constructed an online information management platform for inpatients’ caregivers and implemented a survey to assess user satisfaction.
Methods
To construct an information management platform .Convenience sampling was implemented with 196 caregivers and 118 nurses from affilited hospital in 2020.
Results
The platform included app and personal computer terminals and ports for inpatients’ caregivers, nurses, and administrators. The approval time for the electronic attendant cards was (3.13 ± 0.73) minutes, was shorter than paper cards (7.12 ± 1.00) minutes. The approval time for nurses was (2.63 ± 0.72) minutes, was significantly shorter than paper cards (7.62 ± 0.73) minutes. Caregivers and nurses satisfaction levels were 95.10% and 95.01%, respectively, and were high for all four evaluated dimensions: operations, services, security, and user experience.
Conclusion
Precise control of caregivers’ movements can be achieved using a digital information management platform, thereby reducing the nurses’ burden, and saving time. Given high ratings by inpatients’ caregivers and nurses, can improve work efficiency.
HDSAP: Heterogeneity-aware dynamic scheduling algorithm to improve performance of nano-scale many-Core processors for unpredictable workloads
Authors: Kia Keihaneh , Rajabzadeh Amir
Published: August 2022

The performance growth in processors has been continuing toward increasing the number of processing cores on the chip and scaling the feature size of transistors. However, in the nano era, side effects of the scaling, such as induced heterogeneities in the performance, power, and soft error rate of identically designed cores, prevent the potential performance from being fully utilized. In this paper, we harness the mentioned side effects in shared-memory multicore processors with unpredictable workloads by a dynamic heuristic scheduling algorithm called HDSAP. The aim of HDSAP is to maximize performance, i.e. the average response time, under power and reliability constraints in presence of induced heterogeneities. In this regard, we use a mathematical model to quantify task to core assignments based on performance variation. We also consider the variation in power to change selected cores when the power constraint is missed. To meet the reliability constraint, we use N-Modular redundancy while being aware of the variation in soft error rate of cores to prevent under/over reliability estimation. To evaluate HDSAP, we run SPLASH benchmark suite on Sniper and MACPat simulators. As a result, the response time of HDSAP reduces by 6%, 8%, and 25% in comparison with similar algorithms under the same power and reliability constraints.