bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigating the Causes of Body Dysmorphic Disorder in Women: Content Analysis
Authors:   Department of Psychology, Faculty of Psychology, Ferdowsi University of Mashhad, Mashhad, Iran., Rajabian Ali Azam , Asghari Ebrahimabad Mohammad Javad ,   Department of Psychology, Faculty of Psychology, Ferdowsi University of Mashhad, Mashhad, Iran., Sharbaf Hamidreza Aghamohammadian ,   Department of Psychology, Faculty of Psychology, Ferdowsi University of Mashhad, Mashhad, Iran., Tabatabaei Seyed Kazem Rasoolzadeh ,   Department of Psychology, Faculty of Psychology, Ferdowsi University of Mashhad, Mashhad, Iran.
Published: May 2023

Background and Aim There is almost no accurate information about the causes of body dysmorphic disorder. Many patients with body dysmorphic disorder who apply for plastic surgery show a negative response to these treatments and sometimes the symptoms get worse. The purpose of the present study was to investigate the causes of body dysmorphic disorder in women. Methods & Materials The present research was a qualitative study with a content analysis type. Variables and categories were obtained by interviewing 15 experts and eight people with body dysmorphic disorder and reviewing 71 articles. Also, to diagnose body dysmorphic disorder, Yale Brown’s Practical Obsession Questionnaire was used in addition to the interviews. The sampling method in this research was purposive sampling. Data analysis was done in three stages: open, central, and selective coding. The validity of the components was checked by calculating the content analysis index. Ethical Considerations In the research, before the interview, written consent was received regarding the specificity and confidentiality of the research (Code: IR.UM.REC.1401.105). Results The influential factors in body dysmorphic disorder were: a. Cultural and social factors b. Psychological factors, and c. Biological factors. Conclusion According to the obtained results, several factors play a role in the occurrence of body dysmorphic disorder, and their identification in different environments, cultures, and societies provides the possibility of developing preventive measures, and designing and developing a suitable treatment model. However, to increase the external validity of the research, it is suggested to conduct similar research in other societies.
Atypical Presentation of Herpes Zoster: A Clinical Case Report
Authors:   Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran., Jafarpour Hamed , Reisi Nazanin ,   Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran., Zeynali Farzad ,   Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran., Anjam Ali ,   Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran., Tajallikhah Ahmad ,   Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Published: May 2023

Introduction: Herpes zoster, which is infected with varicella zoster virus (VZV), is a neurological infection and an immunodeficiency syndrome. Most patients who contact physicians complain of itchy and sometimes painful skin rashes. Herpes zoster, also known as "shingles," results from the reactivation of VZV in the dorsal ganglia. Most skin patches occur on the hands or abdomen; rashes on the feet are rare. We aimed to report Herpes zoster presentation in the foot. Case Presentation: A 47-year-old male patient presented to private practice with a rash, itching, and pain in the left lower extremity for 3 days. He was diagnosed with herpes zoster and symptoms were relieved by the administration of acyclovir five times daily for one week. The patient was advised to use Calamine lotion, a cool bath, and a cold compress to relieve the pain and itching. On his next visit to the office, the rash on the left lower extremity disappeared after using the prescriptions and methods. Conclusion: Considering that the prevalence of herpes zoster in the hands and feet is very low and only 7 cases have been reported in the world. This case was reported for the first time in Iran. Knowing the presentation of the disease and getting to know the patients' complaints can help in timely diagnosis and control.
Desplazamiento ambiental forzado. La pertinencia de una reflexión conceptual.
Authors: Rivera Farfán Carolina
Published: May 2023

La aceleración e intensidad de los actuales procesos migratorios en diversas partes del mundo nos reta a hilar fino para poder distinguir las particularidades de las diferentes maneras en que se producen las movilidades humanas. La migración por causas económicas, políticas, sociales y por los altos índices de violencia ha acaparado la mayor atención en nuestros análisis. Si bien los desplazamientos ambientales forzados están sobre la mesa de los debates, hoy es más importante que nunca continuar discusiones y propuestas que posibiliten la formulación de acciones y políticas que los atiendan. Este artículo se acerca, en la primera parte, a la reflexión sobre la pertinencia de entender un marco conceptual del desplazamiento ambiental y desplazamiento ambiental forzado referidos a personas afectadas por eventos hidrometeorológicos. La segunda parte, toma el emblemático caso de los afectados de la localidad Juan del Grijalva, en el norte de Chiapas, que en 2007 sufrió las consecuencias del deslizamiento de la ladera ribereña que inundó el poblado. La Ciudad Rural Sustentable fue la solución que el Estado implementó para reubicar a los desplazados por el desastre, provocado por razones asociadas al evento hidrometeorológico y al inadecuado manejo de los embalses de la presa Peñitas en el río Grijalva, que condujo a los pobladores a emergentes vulnerabilidades y a otras múltiples movilidades. Interesa asimismo conocer las percepciones y las interpretaciones que las personas afectadas tuvieron y, aún hoy día, tienen sobre el evento que trastocó su vida toda.
Pengenalan Augmented Reality Di SMK Al-Bukhary Labuhan Batu Sebagai Media Untuk Mempromosikan Industri Pariwisata
Authors: Wijaya Rian Farta , Utomo Rahmad Budi
Published: May 2023

Semenjak virus covid 19 menyebar ke pelosok negeri, hampir seluruh sector usaha mengalami penurunan pendapatan. Salah satunya adalah sector pariwisata. Saat ini sector pariwisata terus melakukan promosi untuk meningkatkan pendapatannya. Promosi dilakukan dengan menggunakan surat kabar, tv, youtube, website, augmented reality, dan masih banyak lagi. Teknologi augmented reality adalah media promosi yang dapat menyampaikan informasi secara menyeluruh. Augmented reality adalah penggabungan objek maya ke dalam dunia nyata. Augmented reality berbentuk aplikasi yang dapat diinstal pada smartphone, dan laptop/pc. Kabupaten labuhan batu juga memiliki tempat wisata yang harus dipromosikan, karena saat ini juga mengalami penurunan pendapatan. Untuk itu perlu dikenalkan mengenai pemanfaatan augmented reality sebagai media promosi kepada masyarakat sekitar labuhan batu terutama Siswa/i SMK Al-Bukhary. Diharapkan siswa/I dapat menciptakan augmented reality yang dapat digunakan untuk mempromosikan industry pariwisata di wilayah labuhan batu.
Pemanfaatan TOGA Sebagai Minuman Herbal Kekinian Bernilai Ekonomi Bagi Ibu PKK Kelurahan Sidomulyo Timur
Authors: Artiray Dheby Putri , Nst Dinda Restu Illahi , Putri Dhea Ananda , Nugraha Septiriandra , Yolanda Nabilla , Pangestu Dimas Rama Adji , Taniran Selo Putra , Malika Ghalluh Nurul , Damayanti Olifia , Purba Rhosie Dhearani
Published: May 2023

Di tengah situasi pandemi COVID-19, TOGA menjadi salah satu pilihan terbaik untuk mengatasi masalah kesehatan secara mandiri sekaligus mengurangi penggunaan obat-obatan kimia. TOGA adalah istilah yang digunakan untuk tanaman budidaya yang bersifat alami dan mudah tumbuh di pekarangan rumah. Tujuan dari kegiatan pengabdian kepada masyarakat ini adalah untuk memberikan pengetahuan tentang peningkatan imunitas tubuh agar terhindar dari infeksi COVID-19 dengan cara pemanfaatan TOGA yang pada hakikatnya kurangnya pengetahuan dan pemahaman ibu-ibu PKK di Kelurahan Sidomulyo Timur. Program ini berlangsung dalam beberapa tahapan berupa penanaman TOGA, pertemuan kerjasama dengan mitra kerja, persiapan dan pembuatan minuman herbal kekinian, sosialisasi penanaman TOGA dan minuman herbal kekinian, dan demonstrasi menggunakan video cara pembuatan minuman herbal kekinian. Hasil dari program ini adalah ibu-ibu PKK di Kelurahan Sidomulyo Timur memiliki pengetahuan terkait pemanfaatan TOGA sebagai minuman herbal kekinian yang dapat meningkatkan kesehatan tubuh dan memiliki nilai ekonomi sehingga dapat menjadi alternatif penghasilan untuk masyarakat.
Preparative Forms of the Plant Growth Regulator Floroxan
Authors:   Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, str. 1, Moscow, 119334 Russia, Khalikov S. S. , Chkanikov N. D. ,   Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, str. 1, Moscow, 119334 Russia
Published: May 2023

The plant growth regulator floroxan, 3,3,3-trifluoro-2-hydroxy-2-[4-(methylamino)phenyl]propionic acid ethyl ester hydrochloride, is the development of the Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences (INEOS RAS) and has been studied for many years. To improve the physicochemical properties of floroxan, many research efforts have been aimed at developing its application forms. Having high efficiency at a dose of 100 mg/L, floroxan has great prospects for the use as a component in compositions with the known preparations for pre-sowing treatment of seeds of cultivated plants. The recent joint studies of researchers from Russia and Uzbekistan allowed for developing and offering for agriculture the promising preparations such as protectants for cereal crops, herbicide antidotes, and compositions for cotton and a number of vegetable crops.
Mechanical Response of Thin Composite Beams Made of Functionally Graded Material Using Finite Element Method
Authors: Boumezbeur Khaled , Khebizi Mourad , Guenfoud Mohamed , Guendouz Ilies
Published: May 2023

Functionally Graded Material (FGM) is a new generation of composite materials, it can be used for different engineering fields according to the loading environment, but the study of its mechanical behavior requires sophisticated numerical and analytical models. Several investigations in these models are available in the literature, however, most of those investigations are based on simplifying assumptions. In this paper, we present a three-dimensional finite element modeling of functionally graded material (FGM) beams subjected to static loading. Material properties are assumed to vary continuously along the beam thickness according to the power-law distribution with linear elastic behavior. The FGM beams are discretized by hexahedral finite elements type C3D20R (continuum stress/displacement, three-dimensional 20-node, reduced integration). We studied several numerical examples of FGM beams and compare the obtained numerical results with those of analytical models in the literature.
Azacitidine, lenalidomide and donor lymphocyte infusions for relapse of myelodysplastic syndrome, acute myeloid leukemia and chronic myelomonocytic leukemia after allogeneic transplant: the Azalena-Trial
Authors: Schroeder Thomas , Stelljes Matthias , Christopeit Maximilian , Esseling Eva , Scheid Christoph , Mikesch Jan-Henrik , Rautenberg Christina , Jäger Paul , Cadeddu Ron-Patrick , Drusenheimer Nadja , Holtick Udo , Klein Stefan , Trenschel Rudolf , Haas Rainer , Germing Ulrich , Kröger Nicolaus , Kobbe Guido
Published: June 2023

Azacitidine (Aza) combined with donor lymphocyte infusions (DLI) is an established treatment for relapse of myeloid malignancies after allogeneic transplantation. Based on its immunomodulatory and anti-leukemic properties we considered Lenalidomide (Lena) to act synergistically with Aza/DLI to improve outcome. We, therefore, prospectively investigated tolerability and efficacy of this combination as first salvage therapy for adults with post-transplant relapse of acute myeloid leukemia, myelodysplastic syndromes and chronic myelomonocytic leukemia. Patients were scheduled for eight cycles Aza (75 mg/m2 day 1-7), Lena (2.5 or 5 mg, days 1-21) and up to three DLI with increasing T-cell dosages (0.5×106-1.5×107 cells/kg). Primary endpoint was safety, while secondary endpoints included response, graft-versus-host disease (GvHD) and overall survival (OS). Fifty patients with molecular (52%) or hematological (48%) relapse of myelodysplastic syndromes (n=24), acute myeloid leukemia (n=23) or chronic myelomonocytic leukemia (n=3) received a median of seven (range, 1-8) cycles including 14 patients with 2.5 mg and 36 with 5 mg Lena daily dosage. Concomitantly, 34 patients (68%) received at least one DLI. Overall response rate was 56% and 25 patients (50%) achieved complete remission being durable in 80%. Median OS was 21 months and 1-year OS rate 65% with no impact of type of or time to relapse and Lena dosages. Treatment was well tolerated indicated by febrile neutropenia being the only grade ≥3 non-hematologic adverse event in >10% of patients and modest acute (grade 2-4 24%) and chronic (moderate/severe 28%) GvHD incidences. In summary, Lena can be safely added to Aza/DLI without excess of GvHD and toxicity. Its significant anti-leukemic activity suggests that this combination is a novel salvage option for post-transplant relapse (clinicaltrials gov. Identifier: NCT02472691).
Effectiveness of topical tacrolimus treatment in vitiligo patients
Authors: Basak Arpan Kumar , Debnath Joya , Das Anupam
Published: June 2023

Background: Vitiligo is an acquired, pigmentary skin disorder that is disfiguring and difficult to treat. Phototherapy and the application of topical corticosteroids are most commonly prescribed. However, these therapies are often not effective and the use of corticosteroids on the face may lead to cutaneous atrophy, telangiectasia, and ocular complications.

Objective: To evaluate the effectiveness of topical tacrolimus treatment in vitiligo patients.

Materials and methods: This prospective, randomized control trial study was conducted among the patients who sought health care in the Dermatology and Venereology out patient department of KYAMC, Enayetpur, Sirajgonj from August 2021 to July 2022. The study was conducted with a view to evaluate the efficacy of topical tacrolimus in vitiligo and to see the adverse effects of topical tacrolimus in the treatment of vitiligo.

Results: This study shows 70 patients were enrolled them 32 were male and 38 were female. The mean age was 28.52±10.98 years. Monthly evaluations were performed. Maximum 61 patients (87.1%) achieved varying levels of repigmentation. 28 patients (40.0%) had reported up to 50% repigmentation. Sign and symptoms of erythema (8.6%) and burning (7.1%) were minimal.

Conclusion: This study revealed that tacrolimus ointment may be an effective and safe option for the treatment of vitiligo. The ease of topical self-administration with minimal side effects makes this novel immunomodulatory agent a promising addition to the therapeutic armamentarium for vitiligo.

Central Medical College Journal Vol 6 No 1 January 2022 Page: 44-48
El Milizho: Textos Fabulosos
Authors:   Universidad del Azuay, Encalada-Vásquez Oswaldo , Rubio Nicole ,   Universidad del Azuay, Ordóñez-Luna Franklin ,   Universidad del Azuay, Tripaldi-Proaño Toa ,   Universidad del Azuay
Published: May 2023

La colección: Textos fabulosos de Oswaldo Encalada Vásquez, es parte de la Línea Editorial Caja Mágica, creada por la Casa Editora de la Universidad del Azuay con el propósito de animar, difundir y fomentar la lectura y literatura ecuatoriana universal en niños y jóvenes. Las colecciones de literatura son libros que, entre otros propósitos, tienen la misión de formar lectores competentes. Estos libros son dispositivos para que el lector, ya sea en el aula o en el lugar que él lo creyere conveniente, disfrute de la magia de la literatura y a la vez ingrese al mundo de la cultura letrada. Esta mañana Juan salió a la hora de costumbre. Llevaba, a la espalda, la mochila y el bolsillo del panatalón algunos puñados de porotos. Es que desde hacía una semana se había iniciado el juego. Aquí empieza la magia con El Milizho Como por arte de magia habían desaperecido los trompos, las bolas, y habían asomado las grandes manadas de porotos de todos los colores... 68 páginas ISBN: 978-9942-618-85-6 e- ISBN: 978-9942-618-86-3 ISBN de la colección: 978-9942-618-76-4
Lorand Benkö Az Árpád-kor magyar nyelvü szövegemlékei; János Balázs Magyar deákság. Anyanyelvünk és az európai nyelvi modell.
Authors: Büky Béla
Published: June 2023

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Efeitos da pandemia de COVID-19 no início do tratamento de neoplasias malignas dos olhos e anexos em crianças e adolescentes
Authors: Rymsza Taciana , Lacerda Julia Polarini , Trindade Sofia Helena Nassar
Published: May 2023

No Brasil, a doença que mais leva crianças e adolescentes a óbito é o câncer. Nessa faixa etária é importante destacar as neoplasias de olhos e anexos. A pandemia provocada pelo Coronavírus SARS-CoV-2, em 2020, alterou a logística operacional estruturada pelo Sistema Único de Saúde (SUS). Neste cenário, a Lei 12.732/2012, que assegura o direito do início do tratamento oncológico em até 60 dias após o diagnóstico, pode ter sido negligenciada. O presente artigo teve por escopo determinar o impacto da Pandemia na aplicabilidade da Lei 12.732/2012 no que concerne às neoplasias de olhos e anexos em crianças e adolescentes. Trata-se de um estudo observacional transversal retrospectivo, fundamentado através de dados de caráter público, disponibilizados na plataforma TABNETBD 1.0 – Painel de Oncologia, oriundos do Ministério da Saúde. A seleção das informações, se deu através das variáveis: faixa etária (0-19 anos), diagnóstico detalhado (neoplasias malignas de olhos e anexos), mês/ano do diagnóstico (janeiro 2019- dezembro 2021) e tempo para início do tratamento. Durante o período analisado, foram notificados 493 casos, sendo 186 em 2019, 145 em 2020 e 162 em 2021. Da amostra total, 137 não possuíam informação de tratamento, 329 estiveram dentro do intervalo de 60 dias entre detecção e início do tratamento e 27 ultrapassaram o limite estipulado pela lei 12.732/2012.
Molecular epidemiological survey of pathogenic trypanosomes in naturally infected cattle in northern Côte d’ivoire
Authors: Ekra Jean-Yves , N’Goran Edouard K. , Mboera Leonard E.G. , Gragnon Biégo Guillaume , Assovié Koco Rita Nadège , Mafie Eliakunda Michael
Published: May 2023

Bovine trypanosomiasis is a significant health concern for livestock intensification in Côte d’Ivoire. This study aimed to determine the prevalence and distribution of pathogenic trypanosomes and identify the most infected cattle breed in northern Côte d'Ivoire. We examined 700 cattle and found that polymerase chain reaction (PCR) was more sensitive (12.3%) than microscopic observation (5.6%). Among the trypanosome species detected in naturally infected cattle, Trypanosoma vivax was 7.3%, Trypanosoma simiae tsavo was 6.7%, and Trypanosoma congolense was 0.4%. The overall prevalence of trypanosome infection in all cattle breeds was 12.3%, while the prevalence in individual breeds was 14.8%, 7.3%, 10.6%, and 12.3% for N’Dama, Baoule, Zebu, and Mere breed, respectively. The infected animals had low packed cell volume, influencing the prevalence. Our findings indicate that bovine trypanosomes are prevalent in Côte d’Ivoire, and their prevalence varies by region and breed. These pathogens include T. vivax, T. simiae tsavo, and T. congolense.
Peningkatan literasi hukum perkawinan untuk mencegah perkawinan anak
Authors: Ichrom Muhamad , Rofiq M. Khoirur , Muafiq Muhammad Sholihul
Published: June 2023

Jumlah perkawinan anak terus meningkat di Kota Semarang dan sebagian besar dilakukan oleh anak dengan latar belakang pendidikan Sekolah Menengah Kejuruan (SMK), salah satunya adalah SMK Ma’arif NU 1 Kota Semarang. Karena itu pengabdian ini bertujuan untuk meningkatkan literasi tentang problematika perkawinan anak sehingga meningkatkan kesadaran siswa untuk mencegah perkawinan. Adapun metode dalam pengabdian ini menggunakan pendekatan Participatory Action Research (PAR) dengan dua tahapan: Pertama, persiapan kegiatan melalui koordinasi, pemetaan masalah pada objek pengabdian, dan pratest. Kedua, pelaksanaan kegiatan: 1) sosialisasi hukum perkawinan anak, 2) diskusi pemetaan problematika perkawinan anak, 3) focus Group Discussion (FGD) dalam merumuskan solusi atas problematika kehidupan remaja dan perkawinan anak, 4) posttest, dan 5) evaluasi kegiatan. Hasil kegiatan ini mampu meningkatkan pengetahuan peserta tentang problematika perkawinan anak di lingkungan SMK dan merumuskan solusinya, sehingga diharapkan dapat mencegah perkawinan anak di SMK Ma’arif NU 1 Semarang. Rekomendasi dari kegiatan ini adalah, 1) optimalisasi peran stakeholder SMK Maarif NU 1 Kota Semarang dalam mencegah perkawinan anak melalui pendampingan oleh guru kelas, pengawasan pergaulan siswa koordinasi dengan wali murid dengan buku kegiatan siswa, 2) meningkatkan kolaborasi penyuluhan hukum antara Perguruan Tinggi, Dinas Kesehatan, dan sekolah, 3) perlu adanya pusat-pusat studi pembelajaran keluarga yang dapat mendampingi masyarakat.
Transarterial radioembolization versus tyrosine kinase inhibitor in hepatocellular carcinoma with portal vein thrombosis
Authors: Hur Moon Haeng , Cho Yuri , Kim Do Young , Lee Jae Seung , Kim Gyoung Min , Kim Hyo-Cheol , Sinn Dong Hyun , Hyun Dongho , Lee Han Ah , Seo Yeon Seok , Lee In Joon , Park Joong-Won , Kim Yoon Jun
Published: May 2023

Background/Aims: Transarterial radioembolization (TARE) has shown promising results in treating advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT). However, whether TARE can provide superior or comparable outcomes to tyrosine kinase inhibitor (TKI) in patients with HCC and PVTT remains unclear. We compared the outcomes of TARE and TKI therapy in treatment-naïve patients with locally advanced HCC and segmental or lobar PVTT.Methods: This multicenter study included 216 patients initially treated with TARE (n=124) or TKI (sorafenib or lenvatinib; n=92) between 2011 and 2021. Baseline characteristics were balanced using propensity score matching (PSM) or inverse probability of treatment weighting (IPTW). The primary outcome was overall survival (OS). The secondary outcomes included progression-free survival (PFS) and objective response rate (ORR).Results: In the unmatched cohort, the median OS of the TARE and TKI groups were 28.2 and 7.2 months, respectively (p<0.001), and the TARE group experienced significantly and independently longer OS compared to the TKI group (adjusted hazard ratio=0.41, 95% confidence interval=0.28–0.60, p<0.001). Similar results were observed in the study cohorts balanced with IPTW (p=0.003) or PSM (p=0.004). Although PFS was comparable between the two groups, the TARE group showed a trend of prolonged PFS in a subpopulation of patients with Vp1 or Vp2 PVTT (p=0.052). In the matched cohorts, the ORR of the TARE group was 53.0–56.7%, whereas that of the TKI group was 12.3–15.0%.Conclusions: For patients with advanced HCC with segmental or lobar PVTT and well-preserved liver function, TARE may provide superior OS compared to sorafenib or lenvatinib.
Relationships between undergraduate medical students’ attitudes toward communication skills learning and demographics in Zambia: a survey-based descriptive study
Authors: Ezeala Mercy Ijeoma Okwudili , Volk John
Published: June 2023

Purpose: This study aimed to detect relationships between undergraduate students’ attitudes toward communication skills learning and demographic variables (such as age, academic year, and gender). Understanding these relationships could provide information for communication skills facilitators and curriculum planners on structuring course delivery and integrating communication skills training into the medical curriculum.Methods: The descriptive study involved a survey of 369 undergraduate students from 2 medical schools in Zambia who participated in communication skills training stratified by academic year using the Communication Skills Attitude Scale. Data were collected between October and December 2021 and analyzed using IBM SPSS for Windows version 28.0.Results: One-way analysis of variance revealed a significant difference in attitude between at least 5 academic years. There was a significant difference in attitudes between the 2nd and 5th academic years (t=5.95, P˂0.001). No significant difference in attitudes existed among the academic years on the negative subscale; the 2nd and 3rd (t=3.82, P=0.004), 4th (t=3.61, P=0.011), 5th (t=8.36, P˂0.001), and 6th (t=4.20, P=0.001) academic years showed significant differences on the positive subscale. Age showed no correlation with attitudes. There was a more favorable attitude to learning communication skills among the women participants than among the men participants (P=0.006).Conclusion: Despite positive general attitudes toward learning communication skills, the difference in attitude between the genders, academic years 2 and 5, and the subsequent classes suggest a re-evaluation of the curriculum and teaching methods to facilitate appropriate course structure according to the academic years and a learning process that addressees gender differences.
Climate-induced changes in ocean productivity and food-web functioning are projected to markedly affect European fisheries catch
Authors: du Pontavice H , Gascuel D , Kay S , Cheung WWL
Published: June 2023

In European waters, climate-induced changes in ocean conditions will alter marine ecosystems, leading to potential repercussions for the European fisheries and the status of exploited species. Here, we used a new version of the EcoTroph model, forced by a regional high-resolution coupled hydrodynamic-ecosystem model, to investigate the effects of climate change on biomass and catch in 15 areas (ICES divisions) of the European Atlantic shelf ecosystems. Based on the projected changes in temperature, zooplankton and benthic secondary producers, we modeled the changes in biomass and catch at each trophic level by the end of the 21st century. We projected that total biomass and catch for the whole Atlantic European seas would decrease by 11.5 and 10.0%, respectively, by 2090-2099 relative to 2013-2017 under a ‘no mitigation’ greenhouse gases emissions scenario (RCP8.5). The projected decrease in catch is 310000 or 240000 t by 2090-2099 under a high (RCP8.5) or a moderate (RCP4.5) emissions scenario, respectively. Some areas, such as the Celtic Sea, would be more affected than others, while the climate impact on the bentho-demersal biomass and catches would be more pronounced, especially toward the higher trophic levels. Our study suggests that climate change may strongly impact European fisheries, with ecological consequences and potential socio-economic repercussions. Future studies using alternative climate and ecosystem models would allow the exploration of uncertainties in projected biomass and catch. While fisheries management is required to adapt to these changes, the projected impacts on catch cannot be avoided without aggressive mitigation of greenhouse gas emissions.
An Update on Medication-Related Osteonecrosis of the Jaw in Patients with Osteoporosis
Authors: Bennett Benjamin , Tahir Hasan , Solanki Kohmal , Ali Nayeem
Published: May 2023

Medication-related osteonecrosis of the jaw (MRONJ) is a feared complication of anti-resorptive or anti-angiogenic therapy, presenting with non-healing areas of bone, which may form de novo or after dental intervention. The condition primarily affects patients under the care of oncologists and rheumatologists. Patients using these medications under the care of rheumatologists are predominantly being treated for osteoporosis, a highly prevalent condition causing considerable morbidity and mortality in the European population.

In the two decades since the condition was first described, there has been considerable progress in the understanding of the pathophysiology of the condition, although this remains incomplete. Additionally, clinicians may now benefit from long-term follow-up data to give a more evidence-based approach to MRONJ risk stratification. At present, there is considerable variation between guidelines produced by advisory groups. This paper focuses exclusively on the osteoporotic cohort, and aims to review recent findings to explore the differences in risk profiles between osteoporotic and oncological cohorts, as well as between different anti-resorptive medications. Further sections discuss prevention and management of MRONJ in osteoporosis, including the timing of tooth extraction, and consider the direction of future research. The findings suggest that patients with osteoporosis treated with bisphosphonates carry an extremely low risk of MRONJ, although denosumab presents a higher risk. Nevertheless, the reduced fracture rate from prompt treatment with anti-resorptives likely outweighs the risk of MRONJ. Dental hygiene should be optimised to reduce risk, and tooth extraction should take place in a timely fashion, with no convincing evidence to support the use of drug holidays. Treatment at present favours a surgical approach, with potential roles for antibiotics, but at present there is insufficient evidence for other medical adjuncts.
TYPOLOGY OF INNOVATIONS IN THE WESTERN LITERATURE OF THE “GREAT DEBATE” PERIOD IN COMPARISON. SOME GENERAL REMARKS
Authors:   Institute of China and Modern Asia of the Russian Academy of Sciences, Moscow, Russian Federation, ERMAKOV DMITRY ,   Financial University under the Government of the Russian Federation,   K.G. Razumovsky Moscow State University of Technologies and Management,   Peoples’ Friendship University, RODIONOV SERGEY ,   Gzhel State University, Electroizolator village, Ramensky district, Moscow region, Russian Federation, KOZLOV VADIM
Published: May 2023

Due to the transition to an economy dominated by import substitution, there is a need for a new understanding of the nature of innovation policy at the firm and industry levels in the scientific sphere of Russia. Under these conditions, the discussion of the turn of the XX-XXI centuries on the innovation policy of the firm, including the discussion of the typology of innovations, has acquired particularly relevant importance, taking into account also the insufficient study in Russia of foreign literature on the theory of the innovation policy of the firm. The article offers a generalized overview of conceptual ideas in the theoretical sphere of the company’s innovation policy, mainly the ideas of the typology of innovation as the central element of the large theory of innovation of the company are touched upon in this paper. The authors conclude that Western management concepts put in the first place the opposition to the need to maintain routine processes and aspirations for the development and implementation of innovations as a central factor in the development of the innovation process at the levels of the firm and industry.
Proposal for a Balanced and Stable International Monetary System
Authors: Rahman Abdurrahman Arum
Published: June 2023

This paper proposes a new model of a shared international monetary system (IMS) that could potentially make the IMS balanced and stable. We call it an “organic system”. The organic system issues a cross-border means of payment called “organic currency”. The organic currency is only for international transactions between member countries. Domestic transactions continue to use their respective national currencies. Non-member countries cannot use the organic currency. Organic and national currencies are interchangeable using an “auto-balancing” exchange rate that follows the fundamentals. We utilize a trade-and-investment simulation involving 5 countries, 20 products, and a 12-month to test the system. Our simulation shows that this model could provide international liquidity to all (member) countries in the world sustainably, eliminate global imbalances, make the IMS naturally stable, and FX reserves tend to be self-sufficient. This system is flexible; it can start from anywhere in the world and any country may join.
The Einstein’s Mass-Energy Equivalence and the Relativistic Mass and Momentum derived from the Newton’s Second Law of Motion
Authors: Annamalai Chinnaraji
Published: May 2023

In the Einstein’s theory of special relativity, the relativistic mechanics is concerned with the motion of bodies whose velocities approach the speed of light. This paper presents the Einstein’s mass-energy equivalence and the equations of relativistic mass, momentum and energy from the Newton’s second law of motion.
Riemann Hypothesis on Grönwall's Function
Authors: Vega Frank
Published: May 2023

Grönwall's function $G$ is defined for all natural numbers $n>1$ by $G(n)=\frac{\sigma(n)}{n \cdot \log \log n}$ where $\sigma(n)$ is the sum of the divisors of $n$ and $\log$ is the natural logarithm. We require the properties of extremely abundant numbers, that is to say left to right maxima of $n \mapsto G(n)$. We also use the colossally abundant and hyper abundant numbers. There are several statements equivalent to the famous Riemann hypothesis. We state that the Riemann hypothesis is true if and only if there exist infinitely many consecutive colossally abundant numbers $N< N'$ such that $G(N)< G(N')$. In addition, we prove that the Riemann hypothesis is true when there exist infinitely many hyper abundant numbers $n$ with any parameter $u > 1$. We claim that there could be infinitely many hyper abundant numbers with any parameter $u > 1$ and thus, the Riemann hypothesis would be true.
Integration of immune cells in organs-on-chips: a tutorial
Authors: Van Os Lisette , Engelhardt Britta , Guenat Olivier T.
Published: June 2023

Viral and bacterial infections continue to pose significant challenges for numerous individuals globally. To develop novel therapies to combat infections, more insight into the actions of the human innate and adaptive immune system during infection is necessary. Human in vitro models, such as organs-on-chip (OOC) models, have proven to be a valuable addition to the tissue modeling toolbox. The incorporation of an immune component is needed to bring OOC models to the next level and enable them to mimic complex biological responses. The immune system affects many (patho)physiological processes in the human body, such as those taking place during an infection. This tutorial review introduces the reader to the building blocks of an OOC model of acute infection to investigate recruitment of circulating immune cells into the infected tissue. The multi-step extravasation cascade in vivo is described, followed by an in-depth guide on how to model this process on a chip. Next to chip design, creation of a chemotactic gradient and incorporation of endothelial, epithelial, and immune cells, the review focuses on the hydrogel extracellular matrix (ECM) to accurately model the interstitial space through which extravasated immune cells migrate towards the site of infection. Overall, this tutorial review is a practical guide for developing an OOC model of immune cell migration from the blood into the interstitial space during infection.
A perfused multi-well bioreactor platform to assess tumor organoid response to a chemotherapeutic gradient
Authors: Wasson Elisa Marie , He Wei , Ahlquist Jesse , Hynes William Fredrick , Triplett Michael Gregory , Hinckley Aubree , Karelehto Eveliina , Gray-Sherr Delaney Ruth , Friedman Caleb Fisher , Robertson Claire , Shusteff Maxim , Warren Robert , Coleman Matthew A. , Moya Monica Lizet , Wheeler Elizabeth K.
Published: May 2023

There is an urgent need to develop new therapies for colorectal cancer that has metastasized to the liver and, more fundamentally, to develop improved preclinical platforms of colorectal cancer liver metastases (CRCLM) to screen therapies for efficacy. To this end, we developed a multi-well perfusable bioreactor capable of monitoring CRCLM patient-derived organoid response to a chemotherapeutic gradient. CRCLM patient-derived organoids were cultured in the multi-well bioreactor for 7 days and the subsequently established gradient in 5-fluorouracil (5-FU) concentration resulted in a lower IC50 in the region near the perfusion channel versus the region far from the channel. We compared behaviour of organoids in this platform to two commonly used PDO culture models: organoids in media and organoids in a static (no perfusion) hydrogel. The bioreactor IC50 values were significantly higher than IC50 values for organoids cultured in media whereas only the IC50 for organoids far from the channel were significantly different than organoids cultured in the static hydrogel condition. Using finite element simulations, we showed that the total dose delivered, calculated using area under the curve (AUC) was similar between platforms, however normalized viability was lower for the organoid in media condition than in the static gel and bioreactor. Our results highlight the utility of our multi-well bioreactor for studying organoid response to chemical gradients and demonstrate that comparing drug response across these different platforms is nontrivial.
Novel homozygous variants in TTC12 cause male infertility with asthenoteratozoospermia owing to dynein arm complex and mitochondrial sheath defects in flagella
Authors: Meng Lanlan , Liu Qiang , Tan Chen , Xu Xilin , He Wenbin , Hu Tongyao , Tu Chaofeng , Li Yong , Du Juan , Zhang Qianjun , Lu Guangxiu , Fan Li-Qing , Lin Ge , Nie Hongchuan , Zhang Huan , Tan Yue-Qiu
Published: June 2023

Introduction: Tracing the genetic causes for male infertility due to asthenoteratozoospermia has revealed at least 40 causative genes, which provides valuable reference for the genetic testing of asthenoteratozoospermia in clinical practice. To identify deleterious variants in the human tetratricopeptide repeat domain 12 (TTC12) gene in a large cohort of infertile Chinese males with asthenoteratozoospermia.

Methods: A total of 314 unrelated asthenoteratozoospermia-affected men were recruited for whole exome sequencing. The effects of the identified variants were evaluated by in silico analysis, and confirmed by in vitro experiments. Intracytoplasmic sperm injection (ICSI) was used to evaluate the efficiency of assisted reproduction technique therapy.

Results and Discussion: Novel homozygous TTC12 variants (c.1467_1467delG (p.Asp490Thrfs*14), c.1139_1139delA (p.His380Profs*4), and c.1117G>A (p.Gly373Arg)) were identified in three (0.96%) of the 314 cases. Three mutants were indicated to be damaging using in silico prediction tools, and were further confirmed by in vitro functional analysis. Hematoxylin and eosin staining and ultrastructural observation of the spermatozoa revealed multiple morphological abnormalities of flagella, with the absence of outer and inner dynein arms. Notably, significant mitochondrial sheath malformations were also observed in the sperm flagella. Immunostaining assays indicated that TTC12 is present throughout the flagella, and was strongly concentrated in the mid-piece in control spermatozoa. However, spermatozoa from TTC12-mutated individuals exhibited almost no staining intensity of TTC12 and outer and inner dynein arms components. The three men accepted ICSI treatment using their ejaculated spermatozoa, and two female partners successfully delivered healthy babies. Our findings provide direct genetic evidence that homozygous variants in TTC12 cause male infertility with asthenoteratozoospermia by causing dynein arm complex defects and mitochondrial sheath malformations in the flagellar. We also demonstrated that TTC12 deficiency-mediated infertility could be overcome by ICSI technology.
Theoretical insights into the methane catalytic decomposition on graphene nanoribbons edges
Authors: Xavier Neubi F. , Payne Anthony J. R. , Bauerfeldt Glauco F. , Sacchi Marco
Published: June 2023

Catalytic methane decomposition (CMD) is receiving much attention as a promising application for hydrogen production. Due to the high energy required for breaking the C-H bonds of methane, the choice of catalyst is crucial to the viability of this process. However, atomistic insights for the CMD mechanism on carbon-based materials are still limited. Here, we investigate the viability of CMD under reaction conditions on the zigzag (12-ZGNR) and armchair (AGRN) edges of graphene nanoribbons employing dispersion-corrected density functional theory (DFT). First, we investigated the desorption of H and H2 at 1200 K on the passivated 12-ZGNR and 12-AGNR edges. The diffusion of hydrogen atom on the passivated edges is the rate determinant step for the most favourable H2 desorption pathway, with a activation free energy of 4.17 eV and 3.45 eV on 12-ZGNR and 12-AGNR, respectively. The most favourable H2 desorption occurs on the 12-AGNR edges with a free energy barrier of 1.56 eV, reflecting the availability of bare carbon active sites on the catalytic application. The direct dissociative chemisorption of CH4 is the preferred pathway on the non-passivated 12-ZGNR edges, with an activation free energy of 0.56 eV. We also present the reaction steps for the complete catalytic dehydrogenation of methane on 12-ZGNR and 12-AGNR edges, proposing a mechanism in which the solid carbon formed on the edges act as new active sites. The active sites on the 12-AGNR edges show more propensity to be regenerated due lower free energy barrier of 2.71 eV for the H2 desorption from the newly grown active site. Comparison is made between the results obtained here and experimental and computational data available in the literature. We provide fundamental insights for the engineering of carbon-based catalysts for the CMD, showing that the bare carbon edges of graphene nanoribbons have performance comparable to commonly used metallic and bi-metallic catalysts for methane decomposition.
Advances in gut microbiome in metabonomics perspective: based on bibliometrics methods and visualization analysis
Authors: Wang Jieyan , Dong Peng , Zheng Shuqian , Mai Yiyin , Ding Jianan , Pan Pinfei , Tang Liugang , Wan Yantong , Liang Hui
Published: May 2023

Background and aims

Gastrointestinal microbial metabolomics is closely related to the state of the organism and has significant interaction with the pathogenesis of many diseases. Based on the publications in Web of Science Core Collection(WoSCC) from 2004 to 2022, this study conducted a bibliometric analysis of this field, aiming to understand its development trend and frontier, and provide basic information and potential points for in-depth exploration of this field.

Methods

All articles on gastrointestinal flora and metabolism published from 2004 to 2022 were collected and identified in WoCSS. CiteSpace v.6.1 and VOSviewer v.1.6.15.0 were used to calculate bibliometric indicators, including number of publications and citations, study categories, countries/institutions, authors/co-cited authors, journals/co-cited journals, co-cited references, and keywords. A map was drawn to visualize the data based on the analysis results for a more intuitive view.

Results

There were 3811 articles in WoSCC that met our criteria. Analysis results show that the number of publications and citations in this field are increasing year by year. China is the country with the highest number of publications and USA owns the highest total link strength and citations. Chinese Acad Sci rank first for the number of institutional publications and total link strength. Journal of Proteome Research has the most publications. Nicholson, Jeremy K. is one of the most important scholars in this field. The most cited reference is “Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease”. Burst detection indicates that Urine, spectroscopy, metabonomic and gut microflora are long-standing hot topics in this field, while autism spectrum disorder and omics are likely to be at the forefront of research. The study of related metabolic small molecules and the application of gastrointestinal microbiome metabolomics in various diseases are currently emerging research directions and frontier in this field.

Conclusion

This study is the first to make a bibliometric analysis of the studies related to gastrointestinal microbial metabolomics and reveal the development trends and current research hotspots in this field. This can contribute to the development of the field by providing relevant scholars with valuable and effective information about the current state of the field.
Oral Water Has Cardiovascular Effects Up to 60 min in Shock Patients
Authors: Guinot Pierre-Grégoire , Nguyen Maxime , Duclos Valerian , Berthoud Vivien , Bouhemad Belaid ,   The water study group
Published: May 2023

Aim: Little is known about the cardiovascular effects of oral water intake in shock patients. This study was designed to assess the effect of oral water on stroke volume and blood pressure during a 1-h time period.

Method and Results: This open-label, randomized clinical trial included patients admitted to intensive care with acute circulatory failure. Three ICU units at the anesthesia and critical care department of the Dijon Bourgogne University Hospital. Patients were randomized 1:1 to an intervention or standard care group. The intervention group received 500 ml of oral water while the standard care group received intravenous administration of 500 ml of physiological saline solution. Baseline SV did not differ between the two groups (36 ml [28;51] vs. 38 ml [30;51], p = 0.952). The number of patients who were fluid responders did not differ between the two groups [n = 19 (76%) vs. n = 18 (72%), p = 1]. The median change in stroke volume during the three time points did not differ between the two groups (p < 0.05). In the intervention group, blood pressure increased up to 60 min. In the control group, blood pressure quickly increased at the end of fluid expansion, then returned close to baseline value at 60 min.

Conclusion: Shock patients who were administered oral water experienced improvements in blood pressure and blood flow up to 60 min when compared with patients who received intravenous saline solution. Further studies are warranted to confirm these effects.

Clinical Trial Registration:www.clinicaltrials.gov, identifier: NCT03951519.
Crustal structure and its tectonic implications beneath the middle–lower Yangtze metallogenic belt in Anhui Province: 3D deep seismic sounding results from airgun source in inland waters
Authors: Guo Wenbin , Yang Zhuoxin , Tian Xiaofeng , Liu Baofeng , Zheng Chenglong , Song Xianghui , Gao Zhanyong , Qiu Yong
Published: May 2023

To evaluate the effectiveness of using airguns as seismic sources in inland waters to detect the regional crustal structure, a mobile large-capacity airgun excitation experiment was conducted in October 2015 in the Anhui section of the middle–lower Yangtze metallogenic belt. In this study, we extracted 1,957 first-arrival phases (Pg) and 2,179 Moho reflection phases (PmP) from the airgun seismic signals, and performed joint inversion of the traveltimes. The inversion results reveal the P-wave high-velocity anomalies above 7 km depth in the upper crust beneath the ore clustering areas, suggesting the source of mineralized materials. The crustal velocity structure characteristics substantially differed above and below a depth of 7 km, indicating the existence of a regional basement detachment surface. The velocity structure in the middle–lower crust, especially in the lower crust show lateral uniformity characteristic, which could be related to that the middle–lower Yangtze metallogenic belt had undergone a MASH metallization process. The Moho is 30–36 km deep, and its uplift zone extends from southwest to northeast in a “V” shape, which is consistent with the planar spreading characteristics of the metallogenic belt, indicating that the asthenosphere uplift and crustal thinning have had a controlling effect on the formation of the metallogenic belt. This study suggests the present-day crust in the region along the Yangtze River in Anhui retains the traces of lithosphere delamination-thinning and basaltic magma underplating during the Yanshan period. Our results indicates that airgun source detection in inland waters can effectively determine the continental crustal structure.