bluuebunny/crossref_metadata_2025 huggingface dataset:
Cryptococcosis among hospitalised patients with COVID‐19: A multicentre research network study
Authors: Chastain Daniel B. , Kung Vanessa M. , Golpayegany Sahand , Jackson Brittany T. , Franco‐Paredes Carlos , Vargas Barahona Lilian , Thompson George R. , Henao‐Martínez Andrés F.
Published: June 2022

It is unclear if there is an association between COVID‐19 and cryptococcosis. Therefore, this study aimed to describe the clinical features, risk factors, and outcomes associated with cryptococcosis in hospitalised patients with COVID‐19. The objectives of this study were to determine the incidence of and examine factors associated with cryptococcosis after a diagnosis of COVID‐19. We used TriNetX to identify and sort patients 18 years and older hospitalised with COVID‐19 into two cohorts based on the presence or absence of a diagnosis of cryptococcosis following diagnosis of COVID‐19. Outcomes of interest included the incidence of cryptococcosis following the diagnosis of COVID‐19 as well as the proportion of patients in each group who had underlying comorbidities, received immunomodulatory therapy, required ICU admission or mechanical ventilation (MV), or died. Propensity score matching was used to adjust for confounding. Among 212,479 hospitalised patients with COVID‐19, 65 developed cryptococcosis. The incidence of cryptococcosis following COVID‐19 was 0.022%. Patients with cryptococcosis were more likely to be male and have underlying comorbidities. Among cases, 32% were people with HIV. Patients with cryptococcosis were more likely to have received tocilizumab (p < .0001) or baricitinib (p < .0001), but not dexamethasone (p = .0840). ICU admission (38% vs 29%), MV (23% vs 11%), and mortality (36% vs 14%) were significantly higher among patients with cryptococcosis. Mortality remained elevated after adjusted propensity score matching. Cryptococcosis occurred most often in hospitalised patients with COVID‐19 who had traditional risk factors, comparable to findings in patients without COVID‐19. Cryptococcosis was associated with increased ICU admission, MV, and mortality.
Effects of diabetes mellitus on dental pulp: A systematic review of in vivo and in vitro studies
Authors: Pimenta Rafaella Milla Nunes , dos Reis‐Prado Alexandre Henrique , de Castro Oliveira Sabrina , Goto Juliana , Cosme‐Silva Leopoldo , Cintra Luciano Tavares Angelo , Benetti Francine
Published: June 2022

Objectives

This systematic review (PROSPERO CRD42021227711) evaluated the influence of diabetes mellitus (DM) on the response of the pulp tissue and in the pulp cells behaviour.

Materials and Methods

Searches in PubMed/MEDLINE, Embase, Web of Science and OpenGrey were performed until March 2022. Studies evaluating the effects of DM in the pulp tissue inflammation and in the cell behaviour were included, followed by risk of bias assessment (Methodological Index for Non‐Randomized Studies and SYRCLE's RoB tools). The meta‐analysis was unfeasible, and a narrative synthesis for each outcome was provided.

Results

Of the 615 studies, 21 were eligible, mainly with in vivo analysis (16 studies). The pulp inflammation (10 studies) was analysed mainly by haematoxylin–eosin stain; DM increased pulp inflammation/degeneration in 9 studies, especially after dental procedures. The cell viability (5 studies) was analysed mostly using MTT assay; DM and glycating agents decreased cellular viability in 3 studies. DM reduced collagen in all of three studies. There were controversial results regarding mineralization; however, increased alkaline phosphatase was reported in three of four studies.

Conclusions

DM seems to increase inflammation/degeneration and mineralization in the pulp tissue while reducing cell proliferation. Further analyses in human pulp are important to provide stronger evidence.
Comparison of compliance with care procedures performed by orthokeratology wearers and their parents and factors affecting compliance
Authors: Yang Bi , Liu Longqian , Cho Pauline
Published: June 2022

Purpose

To compare the levels of compliance with care routines of orthokeratology (ortho‐k) wearers and their parents and to identify factors affecting compliance in a hospital setting in Chengdu, China.

Methods

Patients who had worn ortho‐k lenses for at least one month were invited to participate in a survey on compliance. Wearers or their parents were required to complete a questionnaire to determine their compliance with hand hygiene, ortho‐k lenses and accessory care procedures.

Results

A total of 200 wearers, 78 male wearers and 122 female wearers, median age 12 (range 8–18) years were enrolled. Except for use of lens solution, the percentage of participants reporting total compliance with all procedures did not differ significantly between lens wearers and their parents. However, compliance for some items was significantly higher when performed by parents p < 0.001–0.01). ‘Eye care practitioner provided instructions’ was a significant protective factor for most procedures (p < 0.001–0.04). Age and sex were significant risk factors for some items (p < 0.001–0.04; p = 0.03–0.04, respectively), with girls having higher compliance than boys. ‘Parental supervision’ was a significant protective factor for some items (p = 0.02–0.04) when wearers performed the procedures themselves. When parents performed lens care procedures, only ‘eye care practitioner provided instructions’ was a significant variable (p = 0.001–0.04).

Conclusion

Some degree of non‐compliance was noted in the majority of ortho‐k wearers, particularly for the care of the lens case and suction holder. Compliance with care of some items was higher when performed by parents. Regular reinforcement of care procedures by practitioners is important, especially for older and male lens wearers. Parental supervision is necessary when children perform lens care procedures themselves, even for older wearers.
A Novel Method for Preoperative Positioning of Total Ankle Replacement Using 3D Digital Model
Authors: Wu Shi‐xun , Liu Shi‐zhang , Ling Ming , Che Yan‐hui , Tian Xin , Duan Xiang‐long , Yi Zhi
Published: June 2022

Objective

To establish a digital model of the ankle joint through 3D imaging technology and explore the preoperative placement of ankle replacement prostheses.

Methods

Computed tomography images of intact ankle joints from 54 cases in the outpatient and inpatient departments of our hospital were collected; according to the INBONE® total ankle system surgery process, the surgery model and surgical osteotomy were finished using MIMICS based on computer simulation method. The shortest distance was measured between the center point and the anterior, posterior, medial, and lateral, respectively, to ensure the precise position of the ankle replacement prosthesis by digital simulation surgery. The relationship between the two variables was analyzed by bivariate correlation analysis.

Results

The dataset of this study included 48 cases of the sub‐data set (26 males and 22 females) and included 27 cases of left ankle and 21 cases of right ankle. The average medial malleolar angle was 18.67°± 2.87°, the average amount of bone resection was 12.13 ± 1.86 cm3, the mid‐anterior distance was 1.72 ± 0.19 cm, the mid‐posterior distance was 2.00 ± 0.19 cm, the ratio of mid‐anterior to mid‐posterior was 0.87, the mid‐medial distance was 1.26 ± 0.17 cm, the mid‐lateral distance was 1.19 ± 0.16 cm, and the ratio of mid‐medial to mid‐lateral was 1.06. After osteotomy, the anteroposterior diameter was 3.73 ± 0.32 cm, the transverse diameter was 2.46 ± 0.27 cm, and the ratio of anteroposterior diameter to transverse diameter was 1.53. In the bottom view, the shape after osteotomy is rectangular. The mid‐anterior distance was strongly negatively correlated with age, the mid‐anterior distance and the amount of bone resection, the mid‐medial distance and the amount of bone resection, the mid‐lateral distance and the amount of bone resection, the mid‐lateral distance and the anteroposterior diameter, the anteroposterior diameter and the transverse diameter were all strongly positively correlated.

Conclusion

The projection point of the lower tibia centerline on the tibial horizontal osteotomy surface is located at a position slightly anterior to the midpoint of the transverse diameter after ankle arthroplasty. The rational positioning of the total ankle replacement is located at both a position slightly anterior to the midpoint of the transverse diameter and midpoint of the anteroposterior diameter, which can be used as a reference method before total ankle arthroplasty surgery.
One year outcomes of atrial fibrillation ablation: Contemporary analysis of the United States Nationwide Readmission Database
Authors: Wu Lingling , Narasimhan Bharat , Bhatia Kirtipal , Wu Ellen , Li Pengyang , Ho Kam S , Shah Arti N. , Kantharia Bharat K.
Published: June 2022

Background

Data on long‐term outcomes of catheter ablation (CA) for atrial fibrillation (AF) in outside of clinical trials settings are sparse.

Objective

We aimed to assess outcomes and readmissions at 1 year following admission for CA for AF.

Methods

Utilizing the Nationwide Readmissions Database (2016–2018), we identified patients with CA among all patients with a primary admission diagnosis of AF, and a control group by propensity score match adjusted for age, sex, comorbidities, CHA₂DS₂‐VASc scores, and the hospital characteristics. The primary outcome was a composite of unplanned heart failure (HF), AF and stroke‐related readmissions, and death at 1 year, and secondary outcomes were hospital outcomes and all‐cause readmission rates.

Results

The study cohort consisted of 29,771 patients undergoing CA and 63,988 controls. Patients undergoing CA were younger with lower CHA₂DS₂‐VASc scores and less comorbidities. Over a follow‐up of 170 ±1.1 days, the primary outcome occurred in 5.2% in CA group and 6.0% of controls (hazard ratio [HR] and 95% confidence interval [CI]: 0.86 [0.76–0.94], p = .002). CA affected AF and stroke related readmission, but showed no effect on HF and mortality outcome. Male sex (HR: 0.83 [0.74–0.94], p = .03), younger age (HR: 0.71 [0.61–0.83], p < .001], and lower CHA₂DS₂‐VASc scores (HR: 0.68 [0.55–0.84], p < .001) were associated with lower risk of primary outcome with CA.

Conclusion

In this study, CA for AF was associated with significantly lower AF and stroke‐related admissions, but not to HF or all‐cause readmission. Better outcomes were seen among males, younger patients, and in patients with less comorbidities and low CHA₂DS₂‐VASc scores.
Rituximab as induction therapy in pediatric kidney transplantation: A single‐center experience in four patients
Authors: Bernard Josselin , Sellier‐Leclerc Anne‐Laure , Demède Delphine , Chamouard Valérie , Ranchin Bruno , Bacchetta Justine
Published: June 2022

Background

The anti‐CD20 rituximab is often used in the treatment of children with steroid‐resistant nephrotic syndrome or EBV‐induced post‐transplant lymphoproliferative disorder. This single‐center series reports the use of rituximab as induction therapy in pediatric kidney transplantation.

Methods

Four children who received rituximab as induction therapy for kidney transplantation since 2016 were retrospectively analyzed. Clinical and laboratory data were extracted from medical records.

Results

The patients (2 boys and 2 girls) were aged from 6.1 to 11.9 years and were treated with rituximab on the day of the transplantation procedure; all the transplants came from deceased donors. In all patients, rituximab was used because of positive EBV viral loads before kidney transplantation. Viral loads remained undetectable for the first 6 months after the transplantation procedure and remained below the 4.5 log threshold thereafter. After a median follow‐up of 2.3 years, none of the patients displayed rejection or de novo donor‐specific antibodies; the glomerular filtration rate remained above 70 ml/min/1.73 m2. No post‐transplant lymphoproliferative disorder was observed.

Conclusion

The results suggest that rituximab can be used as induction therapy to prevent EBV replication and its complications in case of positive viral load prior to kidney transplantation.
Putting analytics into action in care coordination research: Emerging issues and potential solutions
Authors: Kumar Subodha , Qiu Liangfei , Sen Arun , Sinha Atish P.
Published: June 2022

Care coordination involves shaping patient care activities and sharing information among all participants concerned with a patient's care to achieve safe and effective care. The objectives of care coordination are to promote sharing of patients’ clinical information, keep patients and families informed, and manage effective referrals and care transitions. Failures in care coordination account for a large amount of waste per year in the United States. Many innovative healthcare organizations have recently recognized the danger of poorly coordinated care and have implemented analytics to improve it. Therefore, more analytics‐based research (especially combining explanatory analytics with predictive analytics) is needed to direct efforts to improve care coordination. This paper focuses on systematically studying the extant literature to understand how analytics play a role in improving care coordination. Our goal is to identify a set of key research questions that would lead to new research areas in the use of analytics for care coordination. Based on these questions, we offer new analytics solution pathways to care coordination problems.
The interactions between Al‐/Fe‐(hydr)oxides and soil organic carbon mediate the aggregation of yellow soils
Authors: Di Xinyue , Xiao Baohua , Tang Haiming , An Xianjin
Published: June 2022

Soil aggregates are essential for improving soil permeability and reducing soil erosion. Still, in high oxide soils, the roles of soil organic carbon (SOC) and Al‐/Fe‐(hydr)oxide in soil aggregation are unclear, which limits our ability to predict how soil aggregation responds to soil management and climate change. In this study, soil samples were collected from three depths of a yellow soil profile (0–12 cm, 12–24 cm and 24–36 cm) and fractionated into aggregates by wet sieving. Organic carbon (OC) and Al‐/Fe‐(hydr)oxide contents of aggregates were determined. We found that the relationships of OC and Al‐/Fe‐(hydr)oxide to aggregate size were depth‐dependent. OC concentrations increased and decreased at 0–12 cm and 24–36 cm depth soils, respectively, as aggregate size decreased. The OC/(Fe + Al) ratios of aggregates suggest that organic carbon will form multi‐layer and mono‐layer coatings on Al‐/Fe‐(hydr)oxide in the 0–12 cm and 24–36 cm depth soils, respectively. This leads to steric hindrances of OC and electrostatic repulsion of Al‐/Fe‐(hydr)oxide at two depths, respectively, and further influenced the aggregation. Based on these findings, we proposed a mechanism in which aggregates are formed by OC and Al‐/Fe‐(hydr)oxide association with the appropriate OC/(Fe + Al) ratio. This mechanism focuses on the role of the OC/(Fe + Al) ratio mediated in soil aggregation. It can account for the inconsistent responses of aggregation and SOC sequestration to exogenous OC addition in field experiments. Further studies are needed and will be helpful to calculate the dose of organic application for formulating healthy and sustainable soil management.
Antibiotics and the transplant patient: The good, the bad, and the ugly
Authors: Silverstein Amy
Published: June 2022

As a heart transplant recipient for 34 years, I have been asked to write an experience‐based opinion on antibiotic stewardship programs (ASPs) in the transplant setting. The aim of this piece is to provide real‐life examples—the good, the bad, and the ugly—to help contextualize the potential impact of an effective transplant‐specific ASP model. The exigency of transplant ASPs is illuminated, and suggested changes that can help patients right away are provided.
Racial differences in red blood cell transfusion in hospitalized patients with anemia
Authors: Prochaska Micah , Salcedo Jorge , Berry Grace , Meltzer David
Published: June 2022

Background

Guidelines recommend transfusion of red blood cells (RBC's) when a hospitalized patient's hemoglobin (Hb) drops below a restrictive transfusion threshold, either at 7 or 8 g. Hospitals have implemented transfusion policies to encourage compliance with guidelines and reduce variation in transfusion practice. However, variation in transfusion practice remains. The purpose of this study was to examine whether there is variation in the receipt of transfusion by patient race.

Methods

Hospitalized general medicine patients with anemia (Hb < 10 g/dL) were eligible. Chi‐squared tests were used to compare the percent of patients receiving a transfusion by race overall and within strata of their nadir Hb. Linear regression was used to test the association between a patient's race, their nadir Hb, receipt of an RBC transfusion, and the number of units transfused.

Results

Four thousand nine hundred and fifty‐one patients consented, including 1363 (28%) who received a transfusion. 71% of patients were African American, 25% were White, and 4% were Other Race. Overall African Americans were less likely to be transfused compared to Whites (25% vs. 30%, p < .01), and within Hb strata below a Nadir Hb of 9 g/dL (Hb 8.0–8.9 g/dL 1% vs. 7%, p < .01; 7.0–7.9 g/dL 15% vs. 28%, p < .01; <7 g/dL 80% vs. 86%, p < .01). African Americans also received fewer units of RBC's (β = −.17, p < .01) overall and at lower Hb levels (β = .14, p < .01) compared to Whites.

Discussion

The Hb level at which patients are transfused at and the total number of RBC units received during hospitalization differ by patient race.
A Reforma da Previdência de 2019 no Brasil e Suas Consequências no Aprofundamento das Desigualdades de Gênero e da Feminização da Pobreza
Authors: Vicente Laila Maria Domith
Published: June 2022

O presente artigo se propõe a analisar a Seguridade Social no Brasil pelo viés da feminização da pobreza, levando em consideração o papel das novas regras da Previdência Social para o agravamento desta realidade. Para o embasamento da citada proposta traçamos um breve relato histórico da constitucionalização da Seguridade Social, assim como de sua importância para a consolidação de princípios constitucionais como o da dignidade da pessoa humana e da solidariedade. Utilizamos como metodologia a análise qualitativa de dados estatísticos, assim como o recurso à pesquisa bibliográfica conceitual e sócio-histórica.
Brazilian Democracy Facing Authoritarian Neoliberalism
Authors: Saad-Filho Alfredo
Published: June 2022

This article offers an interpretation of the election of Jair Bolsonaro as President of Brazil, based on the examination of its three political drivers. First the economic and political crisis of global neoliberalism, and their implications for developing countries. Second, the cycles of the Brazilian left, which culminated in the rise and decline of the Workers’ Party (PT). Third, the global rise of an authoritarian modality of neoliberalism in developing as well as advanced economies. The article concludes with an assessment of the strengths and fragilities of the Bolsonaro administration, and the challenges facing the Brazilian left.
Mechanism Analysis of Falling Film Evaporation Two-Phase Flow in Narrow Channels
Authors: Guo Lei , Hu Jing , Zhang Shusheng
Published: June 2022

As an efficient heat and mass transfer technology, falling film evaporation has attracted more and more scholars' attention. In this paper, a falling film evaporation platform was established to discuss the mechanism of two-phase flow in narrow channels. The width of the channel varied from 0.5 to 2.0 mm. We focused on the relationship between heat transfer characteristics with flow patterns, channel width, and pressure loss. Three kinds of flow patterns were observed: bubble flow, restricted bubble flow, and dry area. In channels with the same width, the initial heat flux of subcooled evaporation increased linearly with the growth of flow rate. But at the same flow rate, the initial heat flux of subcooled evaporation decreased when the channel width became larger. The heat transfer coefficient on the wall was influenced by the bubble generation frequency and bubble separation diameter. Higher bubble generation frequency led to smaller bubble separation diameter. Through mathematical analysis, it was found that the heat transfer coefficient changed with the channel size. And a boundary was observed between the strengthening and weakening status. The comparison of theoretical and experimental values showed good agreement.
A Modular Magnetic Resonance Imaging-Compatible Pipette Simulator to Evaluate How Design Affects the Basilar Thumb Joint Mechanics
Authors: Norton Nolan M. , Fischer Kenneth J.
Published: June 2022

People who frequently use micropipettes experience hand and upper limb disorders. The basilar thumb joint, also known as the first carpometacarpal or trapeziometacarpal joint, is commonly affected by osteoarthritis (OA). Mechanical factors are associated with OA initiation and progression. We developed a magnetic resonance imaging (MRI)-compatible modular micropipette simulator to improve understanding of how micropipette design affects basilar thumb joint contact mechanics. The micropipette simulator also addresses limitations of current techniques for studying pipetting and basilar thumb joint mechanics. Its modularity will allow future studies to examine handle design parameters such as handle diameter, cross-sectional shape, and other features. A micropipette simulator with a cylindrical handle (length 127 mm, diameter 25 mm) was used with one subject to demonstrate the system's feasibility. Contact areas were within the range of prior data from basilar thumb joint models in power grasp and lateral pinch, and contact pressures were the same order of magnitude.
Two-dimensional superconductivity at the surfaces of KTaO
3
gated with ionic liquid
Authors: Ren Tianshuang , Li Miaocong , Sun Xikang , Ju Lele , Liu Yuan , Hong Siyuan , Sun Yanqiu , Tao Qian , Zhou Yi , Xu Zhu-An , Xie Yanwu
Published: June 2022

The recent discovery of superconductivity at the interfaces between KTaO
3
and EuO (or LaAlO
3
) gives birth to the second generation of oxide interface superconductors. This superconductivity exhibits a strong dependence on the surface plane of KTaO
3
, in contrast to the seminal LaAlO
3
/SrTiO
3
interface, and the superconducting transition temperature
T
c
is enhanced by one order of magnitude. For understanding its nature, a crucial issue arises: Is the formation of oxide interfaces indispensable for the occurrence of superconductivity? Exploiting ionic liquid (IL) gating, we are successful in achieving superconductivity at KTaO
3
(111) and KTaO
3
(110) surfaces with
T
c
up to 2.0 and 1.0 K, respectively. This oxide-IL interface superconductivity provides a clear evidence that the essential physics of KTaO
3
interface superconductivity lies in the KTaO
3
surfaces doped with electrons. Moreover, the controllability with IL technique paves the way for studying the intrinsic superconductivity in KTaO
3
.
Single-nucleosome imaging reveals steady-state motion of interphase chromatin in living human cells
Authors: Iida Shiori , Shinkai Soya , Itoh Yuji , Tamura Sachiko , Kanemaki Masato T. , Onami Shuichi , Maeshima Kazuhiro
Published: June 2022

Dynamic chromatin behavior plays a critical role in various genome functions. However, it remains unclear how chromatin behavior changes during interphase, where the nucleus enlarges and genomic DNA doubles. While the previously reported chromatin movements varied during interphase when measured using a minute or longer time scale, we unveil that local chromatin motion captured by single-nucleosome imaging/tracking on a second time scale remained steady throughout G
1
, S, and G
2
phases in live human cells. This motion mode appeared to change beyond this time scale. A defined genomic region also behaved similarly. Combined with Brownian dynamics modeling, our results suggest that this steady-state chromatin motion was mainly driven by thermal fluctuations. Steady-state motion temporarily increased following a DNA damage response. Our findings support the viscoelastic properties of chromatin. We propose that the observed steady-state chromatin motion allows cells to conduct housekeeping functions, such as transcription and DNA replication, under similar environments during interphase.
Magnetic-field-dependent stimulated emission from nitrogen-vacancy centers in diamond
Authors: Hahl Felix A. , Lindner Lukas , Vidal Xavier , Luo Tingpeng , Ohshima Takeshi , Onoda Shinobu , Ishii Shuya , Zaitsev Alexander M. , Capelli Marco , Gibson Brant C. , Greentree Andrew D. , Jeske Jan
Published: June 2022

Negatively charged nitrogen-vacancy (NV) centers in diamond are promising magnetic field quantum sensors. Laser threshold magnetometry theory predicts improved NV center ensemble sensitivity via increased signal strength and magnetic field contrast. Here, we experimentally demonstrate laser threshold magnetometry. We use a macroscopic high-finesse laser cavity containing a highly NV-doped and low absorbing diamond gain medium that is pumped at 532 nm and resonantly seeded at 710 nm. This enables a 64% signal power amplification by stimulated emission. We test the magnetic field dependency of the amplification and thus demonstrate magnetic field–dependent stimulated emission from an NV center ensemble. This emission shows an ultrahigh contrast of 33% and a maximum output power in the milliwatt regime. The coherent readout of NV centers pave the way for novel cavity and laser applications of quantum defects and diamond NV magnetic field sensors with substantially improved sensitivity for the health, research, and mining sectors.
The circadian immune system
Authors: Wang Chen , Lutes Lydia Kay , Barnoud Coline , Scheiermann Christoph
Published: June 2022

The immune system is highly time-of-day dependent. Pioneering studies in the 1960s were the first to identify immune responses to be under a circadian control. Only in the last decade, however, have the molecular factors governing circadian immune rhythms been identified. These studies have revealed a highly complex picture of the interconnectivity of rhythmicity within immune cells with that of their environment. Here, we provide a global overview of the circadian immune system, focusing on recent advances in the rapidly expanding field of circadian immunology.
The mammalian SKIV2L RNA exosome is essential for early B cell development
Authors: Yang Kun , Han Jie , Gill Jennifer G. , Park Jason Y. , Sathe Meghana N. , Gattineni Jyothsna , Wright Tracey , Wysocki Christian , de la Morena M. Teresa , Yan Nan
Published: June 2022

The SKIV2L RNA exosome is an evolutionarily conserved RNA degradation complex in the eukaryotes. Mutations in the
SKIV2L
gene are associated with a severe inherited disorder, trichohepatoenteric syndrome (THES), with multisystem involvement but unknown disease mechanism. Here, we reported a THES patient with
SKIV2L
mutations showing severe primary B cell immunodeficiency, hypogammaglobulinemia, and kappa-restricted plasma cell dyscrasia but normal T cell and NK cell function. To corroborate these findings, we made B cell–specific
Skiv2l
knockout mice (
Skiv2l
fl/fl
Cd79a-Cre
), which lacked both conventional B-2 and innate-like B-1 B cells in the periphery and secondary lymphoid organs. This was linked to a requirement of SKIV2L RNA exosome activity in the bone marrow during early B cell development at the pro–B cell to large pre–B cell transition. Mechanistically,
Skiv2l
-deficient pro–B cells exhibited cell cycle arrest and DNA damage. Furthermore, loss of Skiv2l led to substantial out-of-frame V(D)J rearrangement of immunoglobulin heavy chain and severely reduced surface expression of μH, both of which are crucial for pre-BCR signaling and proliferative burst during early B cell development. Together, our data demonstrated a crucial role for SKIV2L RNA exosome in early B cell development in both human and mice by ensuring proper V(D)J recombination and
Igh
expression, which serves as the molecular basis for immunodeficiency associated with THES.
A Three-Section Subnanosecond Electron Accelerator
Authors: Tarasenko V. F. , Alekseev S. B. , Baksht E. Kh.
Published: June 2022

Abstract—

The design of a subnanosecond accelerator composed of three sections and a gas-filled diode and results of its testing are presented. The three sections of the accelerator are a double forming line, a ferrite line, and a line with a variable wave impedance. A beam current amplitude of ≈2.7 kA has been measured behind the anode foil at a pulse width at half-maximum of ≈370 ps. Using this accelerator and a standard spectrometer, Cherenkov radiation and pulsed cathodoluminescence have been investigated in KU-1 fused silica, polymethyl methacrylate, and KBr crystal samples.
Explicitly controlling electrical current density overpowers the kinetics of the chlorine evolution reaction and increases the hydrogen production during seawater electrolysis
Authors: Koster John , Tornøe Søren , Kobayashi Nobuhiko Paul , Potts Donald
Published: June 2022

The chlorine evolving reaction (CER) that subdues the oxygen evolving reaction (OER) during the electrolysis of seawater has long been an impediment to the attainment of producing hydrogen in volume without generating harmful byproducts containing chlorine. Using various often expensive catalysts to suppress CER and promote OER frequently requires complex chemical processes and is commonly limited to an operational electrical current density Jc of less than 1 A/cm2, which limits the production rate of hydrogen. In this paper, a new approach to suppress CER and increase the production rate of hydrogen. Two unconventional features in our approach are: the use of Jc (>10 A/cm2) much larger than those typically used (Jc <1 A/cm2) in seawater electrolysis and the use of consumable electrodes, shaped as rods of graphite. The approach allows us to safely reach an electrochemical regime wherein CER is drastically reduced, correspondingly increasing the production rate of hydrogen. Provided the core finding – CER is greatly reduced at larger Jc – in the experiment, a finite element (FE) modeling was conducted to address the question: What are the implications of using higher Jc in electrolysis? The FE modeling indicates that the substantial reduction in CER is associated with a large gradient in the electric field established between a pair of rod-shaped electrodes at higher Jc. Our study suggests that explicitly controlling Jc at a much higher level (>10 A/cm2) than conventionally used in seawater electrolysis (Jc <1 A/cm2) reduces CER to negligible levels – an environmental incentive – while potentially producing much more hydrogen per unit time – an economic incentive – than with seawater electrolysis at lower Jc.
Guidelines on models of diabetic heart disease
Authors: Heather Lisa C. , Hafstad Anne D. , Halade Ganesh V. , Harmancey Romain , Mellor Kimberley M. , Mishra Paras K. , Mulvihill Erin E. , Nabben Miranda , Nakamura Michinari , Rider Oliver J. , Ruiz Matthieu , Wende Adam R. , Ussher John R.
Published: June 2022

Diabetes is a major risk factor for cardiovascular diseases, including diabetic cardiomyopathy, atherosclerosis, myocardial infarction, and heart failure. As cardiovascular disease represents the number one cause of death in people with diabetes, there has been a major emphasis on understanding the mechanisms by which diabetes promotes cardiovascular disease, and how antidiabetic therapies impact diabetic heart disease. With a wide array of models to study diabetes (both type 1 and type 2), the field has made major progress in answering these questions. However, each model has its own inherent limitations. Therefore, the purpose of this guidelines document is to provide the field with information on which aspects of cardiovascular disease in the human diabetic population are most accurately reproduced by the available models. This review aims to emphasize the advantages and disadvantages of each model, and to highlight the practical challenges and technical considerations involved. We will review the preclinical animal models of diabetes (based on their method of induction), appraise models of diabetes-related atherosclerosis and heart failure, and discuss in vitro models of diabetic heart disease. These guidelines will allow researchers to select the appropriate model of diabetic heart disease, depending on the specific research question being addressed.
Impact of Flipped Classroom Approach on Students’ Learning in Post-Pandemic: A Survey Research on Public Sector Schools
Authors: Mujtaba Asad Muhammad , Athar Ali Roha , Churi Prathamesh , Moreno-Guerrero Antonio-José
Published: June 2022

This research focuses on the increasing dependency on flipped classrooms with the merger of distance teaching and learning instead of face-to-face classrooms during the pandemic, which impacted student’s performance and learning post-pandemic. The primary purpose of this research study was to identify support, motivation, participation, collaboration, assessment, and feedback gained through the use of flipped classrooms with the merger of distance teaching instead of a physical classroom in the pandemic situations and the challenges faced by teachers in using flipped classroom. The main intention is to analyze flipped classroom effectiveness as an emerging concept in a pandemic situation. In this research, a methodology is recommended step by step below in the methodology section—a quantitative research method used to collect accurate and reliable results. A survey research method was used in this study. The populations of 90–73 respondents among higher secondary grade students of the public school in Sukkur were selected for data collection. For managing the data, SPSS statistics software was used. In inferential statistics, an independent-samples t-test was used for the analysis of data. The results were analyzed based on gender mean score. The significant findings from this study suggested that the flipped classroom is a practical learning approach that enhances student engagement, performance, and learning in the class. It is summed up that a large number of students favoured the flipped classroom approach over traditional pedagogy. This study will help to further integrate this approach into higher levels of institutions by keeping in mind its effectiveness and hindrances in Pakistan.
Innovative Research on Ideological and Political Education in Colleges and Universities Based on Intelligent Wireless Network Environment
Authors: Fei Qingmei
Published: June 2022

The current technological growth has made artificial intelligence techniques reach every industry. One such industry is education, which uses AI techniques such as machine learning for university courses. This article considers research on the ideological and political education in colleges and universities based on artificial intelligence and machine learning in a wireless network environment. Ideology is a set of ideas that guide politics and is also referred to as a common idea that a group of people shares. Machine learning is referred to as part of artificial intelligence that uses computer algorithms and statistical models to analyze the data. It can learn and adapt itself with the help of the data. The advantage of machine learning is that it does not require human intervention. The proposed system includes machine learning and artificial intelligence in ideology and political education. Machine learning techniques will revolutionize the educational sector with their efficiency and advantages. Thus, it is found that artificial intelligence and machine learning techniques provide enhanced teaching and learning in ideological and political education provided by colleges and universities. In this research binary search algorithm (BSA) is implemented to analyze the teaching and learning process. BSA is compared with the traditional classroom education and statistical learning methodology and observed that BSA has achieved 95% accuracy in the education training and testing and is higher than the other methods.
The Application of the Gestalt Theory in Music Psychotherapy for Piano
Authors: Cai Fukun
Published: June 2022

This paper presents an in-depth study and analysis of the application of the Gestalt theory to music psychotherapy for piano. The paper focuses on how to apply the “whole and part” and “epiphany” perspectives of the Gestalt learning theory to singing and music appreciation lessons. In addition, the Gestalt school’s ideas of developing creative thinking, creating problematic situations, and transferring learning were demonstrated through the implementation of teaching cases. There are differences in the effects of different music on the distribution of body surface temperature; there are differences in the effects of yang music on the Directing Vessel compared to the effects of yin music on the Directing Vessel, and the effects are following the hierarchical model of thinking; there are individual differences in the magnitude of the effects of the same music on the body surface temperature of different people, and the identification of music needs to be combined with the three factors. The wavelet energy entropy (WEE) characteristics of EEG signals were extracted as the input of the designed and optimized deep belief network model, and the average emotional classification accuracy of EEG signals in the left and right brain regions could be obtained as 84.20% and 83.07%, respectively, under the condition of distinguishing brain regions and different music environments. Compared with the classification accuracies of DBN, restricted Boltzmann machine (RBM), and K nearest neighbor (kNN) algorithms in mixed music environments, the classification effects were improved by about 3.49%, 12.89%, and 7.24%. Relying on the ability-poor theory and Weiner attribution theory, different types of secondary school students, their psychological characteristics, and their causes were pointed out. Combined with the psychological characteristics, the case study illustrates the positive effect of music therapy on psychological support.
Workplace Flexibility Analysis in Cyberphysical Human Systems Using Cloud-Enabled Deep Autoencoder Networks
Authors: Farashaei Danial , Honarbakhsh Amin , Movahedifar Seyed Mojtaba , Shakeri Eghbal
Published: June 2022

To examine the correlation between worker safety, workplace interpersonal problems, and individual flexibility within a cyberphysical human system (CPHS), we employed a stacked autoencoder (SAE) approach and a cloud-based computing environment. The study’s statistical population includes construction companies in Mashhad, Iran. To collect data, descriptive surveys and applied research approaches are employed. Thus, data is collected using a cloud-based platform, data processing tools, and information analysis methods. It is our main objective to figure out how to reduce construction accidents and make people safer. Our study used a sample of 200 people to study the entire study population because it is difficult to study the entire study population. There were 151 valid questionnaires collected after the questionnaire distribution. We developed a 28-item questionnaire as part of the study in addition to the Questionnaire on Experience and Evaluation of Work (QEEW). Implementing an optimized SAE network can reduce dangerous situations, physical injuries, supervisor conflict, workplace stress, interpersonal conflict, and colleagues’ involvement. As a consequence of the large amount of data needed for quick analysis and mechanism construction, cloud computing performed admirably. The study of interpersonal conflicts and individual flexibility among construction workers was necessary because only limited research had been conducted on these topics.
Research and Application of Key Technologies of Ocean Virtual Scene Display Based on Digital Image
Authors: Ren Xiaonan , Ning Jie , Cho Joung Hyung
Published: June 2022

Digital imaging technology originated from scientific and technological competitions in the military field, allowing continuous high-intensity digital photography work. The ocean virtual scene display of digital images is more flexible and more tolerant. The ocean virtual scene can be used to model the structure of different regions, create a diversified ocean experience pavilion as much as possible, and create a multi-dimensional visual product. Through this research, we get: 1. The best frame rate is 100.607 when High Dynamic Range (HDR) is off and 98.47 when HDR is on. When A =0.0161, Me =26, K1 = 0.6488, G =28, K2 = -0.0072, α =58, Omega =2.5229, β =78. The simulation experiment of ocean scene construction shows that it only needs to calculate the ocean virtual scene of LONC area, and repeatedly set and splice the ocean virtual scene to form a large modeling scene. 2. When the FFT model is optimized, the parameters are set as follows: Meta Flight =0.946, Open Flight =0.441, α =0.828, Omega =089, β =0.754; The optimal parameters of multiple kernel learning model in ocean virtual scene are: Meta Flight =0.757, Pen Flight =0.818, α =0.781, Omega =0.157, β =1.739; The best parameters of the ocean virtual scene of Vega Prime model are: Meta Flight =0.285, Open Flight =0.803, α =0.701, Omega =0.725, and β =0.757. And the constructed ocean virtual scene can achieve the best effect. 3. In the FFT model, when the related technical parameters are set optimally, the two-dimensional animation is integrated into the digital image as a visual special effect element or an animation subtitle, so that the digital image is more interesting, creative and propagable.
First-Principles Calculations to Investigate Structural, Electronic, Optical, and Elastic Properties of Ceria
Authors: Asefa Eressa Lemessa , Gerbaba Edossa Teshome
Published: June 2022

The structural, electronic, optical, and elastic properties of Ceria (CeO2) were investigated using local density approximation (LDA), PBE, DFT + U, and PBE0 approximations. In all approximations, the convergence test of total energy with respect to kinetic energy cutoff, k-point, and lattice constant of CeO2 was performed consequently to increase the accuracy of computations. The O (2p)-Ce (4f) bandgap of CeO2 calculated using DFT + U (3.0 eV) is consistent with experimentally reported value (3.0–3.33 eV) than with LDA (2.2 eV), PBE (2.5 eV), and PBE0 (4.47 eV). Both LDA and PBE underestimated the bandgap of CeO2 while the PBE0 overestimated the bandgap of CeO2 as compared to the experimental value. The optical properties such as the imaginary part of the dielectric function (

ε

2

), extinction coefficient (k), and refractive index (n) of ceria obtained using the three approaches are also consistent with the available theoretical and experimental data. In addition, the maximum peak for absorption coefficient was found at about 13 eV for (LDA and PBE) and around 11 eV for DFT + U calculations. Furthermore, the analyses of optical properties support the electronic properties of ceria. The elastic properties such as bulk modulus, shear modulus, Young’s modulus, Poisson’s ratio, Debye temperature, and Debye sound velocity were computed to investigate the mechanical properties of CeO2 and compared with the experimental and theoretical results. The result of elastic parameters found confirms that CeO2 is mechanically stable and has potential for a variety of different electronic applications.
Tophaceous Gout in the Pancreas: Case Reports and Review of the Literature
Authors: Choi Soo , Voskanian Natalie , Ramos Jeffrey , Nguyen Katherine H.Y.
Published: June 2022

We report 3 patients who presented with abnormal pancreatic contents that were initially nondiagnostic but were eventually found to have urate crystal deposition consistent with pancreatic tophaceous gout. Our first case involved an ICU patient who had fever of unknown origin and refractory pancreatic pseudocyst. The other 2 patients presented with abdominal pain associated with a pancreatic mass which mimicked malignancy. After further investigation, we were able to identify pancreatic tophaceous gout as the diagnosis. Initiation of therapy led to resolution of pancreatitis in the first patient and resolution of abdominal pain and decrease in size of a pancreatic mass in the other 2 patients. The recognition of clinical gout involving the pancreas has important implications in the evaluation and care of these patients who are at high risk for tophaceous gout. In addition, the importance of specimen preparation that preserves crystals for viewing is discussed.
Bidirectional CPW Fed Quad-Band DRA for WLAN/WiMAX Applications
Authors: Iqbal Assad , Owais Owais , Kaabar Mohammed K. A. , Shakir Mustafa , Ullah Inam , Khan Aftab Ahmad , Khan Abd Ullah , Rehman Ateeq Ur
Published: June 2022

Due to the size constraint, antennas with compact size are required that can support multibands with single radiating element. Dielectric resonator antenna (DRA) can support multiple modes with good efficiency and gain using single radiating element. In this paper, a quad-band DRA is proposed for WLAN/WiMAX bands using a single CPW feed. Out of four bands, WLAN (2.37-2.55) GHz, (5.15-5.35) GHz, and (5.6-5.83) GHz are achieved by the excitation of fundamental and higher-order modes whereas WiMAX (3.58-3.72) GHz band is achieved by dielectric loading of the DR. Dielectric loading makes it possible to operate the antenna at desired frequency band. Due to the partial ground plane and single coplanar waveguide (CPW) feed radiation pattern of the proposed antenna is bidirectional. The design is efficient in terms of radiation efficiency. Simulated and measured results show that it can be a suitable candidate for WLAN and WiMAX applications.
[Retracted] Correlation Analysis of DNA Methylation in the von Willebrand Factor Promoter Region and the Risk of Unexplained Recurrent Hemophilia: Systematic Review and Meta‐Analysis
Authors: Dong Jing , Li Jie , Yang Ling , Kong Qiuhong , Zhang Zhirong , Zhang Hong
Published: June 2022

This study systematically reviewed the effect of DNA methylation in the promoter region of the coagulation factor vWF gene on the risk of unexplained recurrent hemophilia. PubMed, Medline, Web of Science, and other computers were used to search the database, and the statistical randomized controlled trials of coagulation factor vWF in the risk analysis of unknown recurrent hemophilia were collected. The Cochrane systematic evaluation method was used to evaluate the quality of the included kinds of literature, and Revman5 software was used to sort out and analyze the kinds of literature. Meta‐analysis showed that there was a statistical difference between the experimental group and the control group in case fatality rate (OR = 1.76, 95% CI (1.29, 2.39), P = 0.0003, I2 = 0%, Z = 3.58), adverse events (OR = 2.38, 95% CI (1.65, 3.45), P < 0.00001, I2 = 0%, Z = 4.60), incidence of joint hemorrhage (OR = 2.52, 95% CI (1.62, 3.91), P < 0.00001, I2 = 0%, Z = 4.12), incidence of subcutaneous stasis (OR = 1.76, 95% CI (1.26, 2.45), P = 0.0009, I2 = 5%, Z = 3.33), and hematoma volume (OR = 1.78, 95% CI (1.32, 2.40), P = 0.0001, I2 = 23%, Z = 3.80). DNA methylation in the promoter region of the coagulation factor vWF gene was significantly associated with the risk of unexplained recurrent hemophilia. Whether demethylation can improve the bleeding index of patients with recurrent hemophilia remains to be further explored.