bluuebunny/crossref_metadata_2025 huggingface dataset:
Hallux Varus
Authors: Matsumoto Takumi , Shah Rajiv , Dave Malhar , Shah Nikesh , Parekh Selene G.
Published: March 2015

The prevalence of hallux varus deformity in rheumatoid arthritis (RA) has been reported to be extremely rare. However, in South Asian Countries, where open-toed shoes are habitual footwear for the majority of people, we have found that hallux varus is a common deformity in patients with RA. This rate of occurrence is much more common than that in published hallux deformities in RA and reinforces the impact of footwear on the development of hallux deformities. In this report, we present 3 illustrative cases of hallux varus developed in patients with RA and review the etiology of hallux varus deformity.

Levels of Evidence: Therapeutic, Level IV: Case Study
Use of Magnesium Sulfate Infusion for the Management of Febrile Illness-Related Epilepsy Syndrome
Authors: Tan Wei Wei , Chan Derrick W. S. , Lee Jan Hau , Thomas Terrence , Menon Anuradha P. , Chan Yoke Hwee
Published: March 2015

Febrile illness-related epilepsy syndrome is a catastrophic epileptic encephalopathy that is highly refractory to most antiepileptic drugs leading to high morbidity and mortality. The authors report the use of a pediatric infusion protocol of continuous intravenous magnesium sulfate for the control of seizures in 2 children with febrile illness-related epilepsy syndrome refractory to multiple antiepileptic drugs in a pediatric intensive care unit of a tertiary care children’s hospital. Both patients, 2 and 16 years of age, respectively, were treated with continuous magnesium sulfate infusion. Serum magnesium concentrations ranging from 2.1 to 5 mmol/L were achieved. Seizure reduction and cessation were noted in 1 patient with magnesium more than 3.0 mmol/L. No significant adverse effects were observed. Magnesium sulfate infusions can be safely used in pediatric refractory status epilepticus. Magnesium sulfate can be considered in the management of children with febrile illness-related epilepsy syndrome.
Vosaroxin and vosaroxin plus low-dose Ara-C (LDAC) vs low-dose Ara-C alone in older patients with acute myeloid leukemia
Authors: Dennis Mike , Russell Nigel , Hills Robert K. , Hemmaway Claire , Panoskaltsis Nicki , McMullin Mary-Frances , Kjeldsen Lars , Dignum Helen , Thomas Ian F. , Clark Richard E. , Milligan Don , Burnett Alan K.
Published: March 2015

Key Points

Vosaroxin alone or together with LDAC does not benefit older acute myeloid leukemia patients not considered fit for intensive therapy. In exploratory analyses, no demographic subgroup showed a survival benefit.
Distributed weighted sum-rate maximization with multi-cell uplink-downlink throughput duality
Authors: Hu Zeming , Zhu Yuanping , Xu Jing , Wang Jiang , Yang Yang
Published: March 2015

The weighted sum-rate maximization (WSRMax) problem is important for the radio resource allocation in wireless networks. In this paper, we focus on solving the WSRMax optimization problem in a Home eNodeB (HeNB) wireless network for the multiple input single output (MISO) downlink transmission. Based on an ameliorated max-min multi-cell uplink-downlink throughput duality, we design a distributed algorithm which contains Loop1 and Loop2 associating with the max-min procedure, respectively. Especially, in Loop2 procedure, we propose a new distributed iteration scheme with the complete proof. During the implementation of the proposed algorithm, randomly deployed HeNBs only need to share information with their neighboring nodes. Simulation results show that the two processes can converge to a stable state, and the network capacity is dramatically improved with the coordination among HeNBs.
A note on the equivalence of some metric and H-cone metric fixed point theorems for multivalued contractions
Authors: Huang Huaping , Radenović Stojan , Ðorić Dragan
Published: March 2015

In this paper, by using Minkowski functional introduced by Kadelburg et al. (Appl. Math. Lett. 24:370-374, 2011) or nonlinear scalarization function introduced by Du (Nonlinear Anal. 72:2259-2261, 2010), we prove some equivalences between vectorial versions of fixed point theorems for H-cone metrics in the sense of Arshad and Ahmad and scalar versions of fixed point theorems for (general) Hausdorff-Pompeiu metrics (in usual sense).
SRD: a Staphylococcus regulatory RNA database
Authors: Sassi Mohamed , Augagneur Yoann , Mauro Tony , Ivain Lorraine , Chabelskaya Svetlana , Hallier Marc , Sallou Olivier , Felden Brice
Published: March 2015

An overflow of regulatory RNAs (sRNAs) was identified in a wide range of bacteria. We designed and implemented a new resource for the hundreds of sRNAs identified in Staphylococci, with primary focus on the human pathogen Staphylococcus aureus. The “Staphylococcal Regulatory RNA Database” (SRD, http://srd.genouest.org/) compiled all published data in a single interface including genetic locations, sequences and other features. SRD proposes novel and simplified identifiers for Staphylococcal regulatory RNAs (srn) based on the sRNA's genetic location in S. aureus strain N315 which served as a reference. From a set of 894 sequences and after an in-depth cleaning, SRD provides a list of 575 srn exempt of redundant sequences. For each sRNA, their experimental support(s) is provided, allowing the user to individually assess their validity and significance. RNA-seq analysis performed on strains N315, NCTC8325, and Newman allowed us to provide further details, upgrade the initial annotation, and identified 159 RNA-seq independent transcribed sRNAs. The lists of 575 and 159 sRNAs sequences were used to predict the number and location of srns in 18 S. aureus strains and 10 other Staphylococci. A comparison of the srn contents within 32 Staphylococcal genomes revealed a poor conservation between species. In addition, sRNA structure predictions obtained with MFold are accessible. A BLAST server and the intaRNA program, which is dedicated to target prediction, were implemented. SRD is the first sRNA database centered on a genus; it is a user-friendly and scalable device with the possibility to submit new sequences that should spread in the literature.
Case Report: Primary dural based diffuse large B-Cell lymphoma in a 14 year-old boy
Authors: Munakomi Sunil , Bhattarai Binod , Srinivas Balaji , Cherian Iype
Published: March 2015

Primary dural lymphoma is a subentity of primary leptomeningeal lymphoma which represents 0.1% of all non-Hodgkin’s lymphomas. Only five cases have been reported so far. We report a very rare case of primary dural-based lymphoma in a 14 year-old boy presenting with mass effect. The patient was managed with excision of the lesion and removal of the involved bone. Post-operatively, the patient showed good recovery. He was then referred to the oncology unit for further chemo- and radiation therapy. A high index of suspicion should therefore be kept in order to diagnose the condition in a timely fashion and then plan for appropriate management since diffuse large cell lymphoma has a relatively benign clinical prognosis.
A Network Structural Approach to the Link Prediction Problem
Authors: Lee Chungmok , Pham Minh , Jeong Myong K. , Kim Dohyun , Lin Dennis K. J. , Chavalitwongse Wanpracha Art
Published: March 2015

The link prediction problem is an emerging real-life social network problem in which data mining techniques have played a critical role. It arises in many practical applications such as recommender systems, information retrieval, and marketing analysis of social networks. We propose a new mathematical programming approach for predicting a future network using estimated node degree distribution identified from historical data. The link prediction problem is formulated as an integer programming problem that maximizes the sum of link scores (probabilities) with respect to the estimated node degree distribution. The performance of the proposed framework is tested on real-life social networks, and the computational results show that the proposed approach can improve the performance of previously published link prediction methods.
Expression of Matrix Metalloproteinase (MMP)-20 and Potential Interaction with Dentin Sialophosphoprotein (DSPP) in Human Major Salivary Glands
Authors: Koli Komal , Saxena Geetu , Ogbureke Kalu U. E.
Published: March 2015

Matrix metalloproteinase-20 (MMP-20) expression is widely regarded as tooth-specific, with expression limited to dental hard tissues. Necessary for sound enamel formation, MMP-20 and MMP-2 proteolytically process dentin sialophosphoprotein (DSPP) into dentin sialoprotein, dentin phosphoprotein, and dentin glycoprotein during tooth formation. In the mid-2000s, three members of the small integrin-binding ligand N-linked glycoproteins (SIBLINGs) were reported to bind specifically with high affinity (nM) to, and activate, three MMPs in vitro: bone sialoprotein with MMP-2; osteopontin with MMP-3; and dentin matrix protein1 with MMP-9. The SIBLING-MMP interaction was confirmed in biological systems such as the ducts of salivary glands, where all five members of the SIBLINGs are expressed. Recently, we documented MMP-20 expression and interaction with DSPP (another member of the SIBLING family) in human oral squamous cell carcinoma. Here we report the expression of MMP-20, and confirm its co-expression and potential interaction with DSPP in human major salivary gland tissues and cell line using immunohistochemistry, immunofluorescence, western blot, quantitative RT-PCR, and proximity ligation assay. This report reinforces our earlier suggestion that the SIBLING–MMP complexes may be involved in the turnover of extracellular proteins damaged by oxidation byproducts in metabolically active duct epithelial systems.
Redefining aspects of participation for amateur film-makers in the Nordic countries
Authors: Huttunen Jetta
Published: March 2015

Since the digital revolution in the 1990s the cultural industries have been shaken by profound changes in the traditional relationships between producer and consumer. In the networked digital community, many have seen the possibilities for amateurs to attain power through access to the tools of production and distribution. Online interaction and self-presentation opportunities add to the participatory aspect of amateur film-makers’ culture. However, boundaries of participation exist and constrain the opportunities of participation for amateur film-makers. The amateur film-makers interact with their surroundings and actively engage in shaping the circumstances of their activities. Indeed, participation includes an increased potential for interaction, but the level of participation is determined by the network of interactions and the restrictions defined by power relations within the media environment. This article focuses on the developments of the online communities of Nordic (Finnish, Swedish, Norwegian and Danish) amateur film-makers seen from the point of view of access, interaction and participation.
Os sistemas de informação geográfica no planeamento estratégico de infra-estruturas de prevenção e supressão de incêndios florestais. Caso de estudo: concelho da Serta
Authors: Saturnino Hugo , Fernandez Paulo , M. Monteiro José
Published: March 2015

Os grandes incêndios florestais têm sido o fenómeno com mais impacto na perturbação dos espaços florestais. A modelação do comportamento e desenvolvimento espacial de uma frente de fogo contribui para melhorar as decisões de localização de infra-estruturas de apoio à supressão de incêndios florestais.
Método de análise de risco de incêndios em favelas: uma abordagem
Authors: Paula Bruno Ana
Published: March 2015

A partir da apresentação das favelas no contexto da habitação popular urbana no Brasil e, em especial, na cidade de São Paulo, o problema dos incêndios é brevemente construído, para então ser explorada a gestão do risco associado a esse tipo de evento, por meio da proposição de um método de análise alinhado aos objetivos, possibilidades e limitações concretas à sua aplicação.
Modelação da erosão do solo e sua verificação numa área florestal recentemente ardida em Açores, centro-norte de Portugal
Authors: Vieira Diana D. C. S. , Malvar M. C. , Nunes J. P. , Keizer J. J.
Published: March 2015

O presente trabalho tem como objectivo avaliar a adequabilidade de dois modelos empíricos de erosão, para o mapeamento do risco de erosão pós-fogo à escala da encosta, com base em Sistemas de Informação Geográfica. Foi desenvolvido no âmbito do projecto EROSFIRE, que pretende avaliar as vantagens e desvantagens de experiências de campo de simulação de chuva para mapear o risco de erosão, fornecendo dados necessários à calibração de modelos.
Considerações sobre risco de erosão na área urbana da Grande Natal/ RN – Brasil
Authors: Ramalho Maria Francisca De Jesus Lírio
Published: March 2015

Este estudo faz parte de uma pesquisa no Brasil sobre erosão urbana, com objetivo de observar, identificar e analisar a causa da erosão do solo na Grande Natal. No contexto procura enfatizar casos de riscos de erosão observados em dois setores: no bairro de Ponta Negra e no bairro de Nova Parnamirim.
Riscos e impactos como produtos das práticas socioespaciais : um estudo prognóstico da cidade de Maringá /PR, Brasil
Authors: Teodoro Pacelli Henrique Martins , Amorim Margarete Cristiane de Costa Trindade
Published: March 2015

As relações multidimensionais, estabelecidas entre a sociedade e o espaço, são concretizadas nas práticas socioespaciais, as quais também produzem a cidade. Sob a influência do sistema de produção capitalista, tais práticas têm colocado o espaço urbano diante às fortes contradições sociais e naturais, traduzidas, comumente, em riscos e impactos.
Threatening disaster or mastered risk? A geo-historical approach of flood risk in urban area. Example of Mulhouse (France)
Authors: Martin B. , Ansel R. , Drescher A. , Guerrouah O. , Glaser R. , Riemann D. , Vitoux M. C. , Vogt S. , With L.
Published: March 2015

The Prevention Plan against Flood Risks in the Ill Basin reveals that the city of Mulhouse (France) is almost entirely free from flood nuisance. This situation appears to result from the building of an important diversion canal for the Ill river during the second half of the 19th century. To improve the undeniable efficiency of the canal, we adopt a historical and geographical perspective at different scales in order to place the devastating floods as well as the urban and river system of protection in a broader context. Those results proceed from the studies carried out within the framework of the French-German program TRANSRISK, financed by the ANR and the DFG.
L’ignition des feux de forêt par l’action de la foudre au Portugal de 1996 à 2008
Authors: Pugnet Lilian , Lourenço Luciano , Rocha João
Published: March 2015

Une étude des incendies de forêt causés par la foudre est présentée pour le Portugal, de 1996 à 2008. A l’aide des données de tous les feux de foudre enregistrés sur cette période, une analyse de la répartition spatiale et temporelle, de ces phénomènes, a été effectuée. Les informations sur les feux de foudre ont été couplées à celles sur l’activité des décharges électriques atmosphériques (DEA) et aux conditions météorologiques. La moyenne mensuelle montre un maximum d’activité des DEA de Mai à Septembre, alors que le minimum d’activité est observé en Janvier et Décembre. Il existe une forte corrélation entre l’activité des DEA et la répartition des feux de foudre.
Risco de ignição de incêndios florestais associado à circulação de material ferroviário em linhas de caminho de ferro
Authors: Lourenço Luciano , Rocha João
Published: March 2015

Os incêndios florestais, motivados por causas antrópicas e naturais, constituem, na actualidade, a principal ameaça à floresta portuguesa. Por sua vez, as causas acidentais, que estão na origem de muitos deles, correspondem a um cluster específico em termos das suas causas.Os incêndios florestais nas imediações e/ou contiguidade da linha de caminho de ferro apresentam um valor relativamente reduzido no contexto geral dos incêndios em Portugal. No entanto, no conjunto das causas acidentais, revelam um quantitativo relativamente significativo, com consequências nos totais de área ardida e, sobretudo, na operacionalidade e interrupção temporária da circulação de composições ferroviárias.
Tau Phosphorylation at Serine 396 Residue Is Required for Hippocampal LTD
Authors: Regan Philip , Piers Thomas , Yi Jee-Hyun , Kim Dong-Hyun , Huh Seonghoo , Park Se Jin , Ryu Jong Hoon , Whitcomb Daniel J. , Cho Kwangwook
Published: March 2015

Tau is required for the induction of long-term depression (LTD) of synaptic transmission in the hippocampus. Here we probe the role of tau in LTD, finding that an AMPA receptor internalization mechanism is impaired in tau KO mice, and that LTD causes specific phosphorylation at the serine 396 and 404 residues of tau. Surprisingly, we find that phosphorylation at serine 396, specifically, is critical for LTD but has no role in LTP. Finally, we show that tau KO mice exhibit deficits in spatial reversal learning. These findings underscore the physiological role for tau at the synapse and identify a behavioral correlate of its role in LTD.
Input-Gain Control Produces Feature-Specific Surround Suppression
Authors: Trott Alexander R. , Born Richard T.
Published: March 2015

In primary visual cortex (V1), neuronal responses are sensitive to context. For example, responses to stimuli presented within the receptive field (RF) center are often suppressed by stimuli within the RF surround, and this suppression tends to be strongest when the center and surround stimuli match. We sought to identify the mechanism that gives rise to these properties of surround modulation. To do so, we exploited the stability of implanted multielectrode arrays to record from neurons in V1 of alert monkeys with multiple stimulus sets that more exhaustively probed center-surround interactions. We first replicated previous results concerning center-surround similarity using gratings representing all combinations of center and surround orientation. With this stimulus set, the surround simply scaled population responses to the center, such that the overall population tuning curve had the same shape and peak response. However, when the center contained two superimposed gratings (i.e., a visual “plaid”), one component of which always matched the surround orientation, suppression selectively affected the portion of the response driven by the matching center component, thereby producing shifts in the peak of the population orientation tuning curve. In effect, the surround caused neurons to respond predominantly to the component grating of the center plaid that was unmatched to the surround grating, as if by reducing the effective strength of whichever stimulus attributes were matched to the surround. These results provide key physiological support for theoretical models that propose feature-specific, input-gain control as the mechanism underlying surround suppression.
The Wnt Effector Transcription Factor 7-Like 2 Positively Regulates Oligodendrocyte Differentiation in a Manner Independent of Wnt/β-Catenin Signaling
Authors: Hammond Elizabeth , Lang Jordan , Maeda Yoshiko , Pleasure David , Angus-Hill Melinda , Xu Jie , Horiuchi Makoto , Deng Wenbin , Guo Fuzheng
Published: March 2015

Genetic or pharmacological activation of canonical Wnt/β-catenin signaling inhibits oligodendrocyte differentiation. Transcription factor 7-like 2 (TCF7l2), also known as TCF4, is a Wnt effector induced transiently in the oligodendroglial lineage. A well accepted dogma is that TCF7l2 inhibits oligodendrocyte differentiation through activation of Wnt/β-catenin signaling. We report that TCF7l2 is upregulated transiently in postmitotic, newly differentiated oligodendrocytes. Usingin vivogene conditional ablation, we found surprisingly that TCF7l2 positively regulates neonatal and postnatal mouse oligodendrocyte differentiation during developmental myelination and remyelination in a manner independent of the Wnt/β-catenin signaling pathway. We also reveal a novel role of TCF7l2 in repressing a bone morphogenetic protein signaling pathway that is known to inhibit oligodendrocyte differentiation. Thus, our study provides novel data justifying therapeutic attempts to enhance, rather than inhibit, TCF7l2 signaling to overcome arrested oligodendroglial differentiation in multiple sclerosis and other demyelinating diseases.
Visual Fixation in Human Newborns Correlates with Extensive White Matter Networks and Predicts Long-Term Neurocognitive Development
Authors: Stjerna Susanna , Sairanen Viljami , Gröhn Riitta , Andersson Sture , Metsäranta Marjo , Lano Aulikki , Vanhatalo Sampsa
Published: March 2015

Infants are well known to seek eye contact, and they prefer to fixate on developmentally meaningful objects, such as the human face. It is also known, that visual abilities are important for the developmental cascades of cognition from later infancy to childhood. It is less understood, however, whether newborn visual abilities relate to later cognitive development, and whether newborn ability for visual fixation can be assigned to early microstructural maturation. Here, we investigate relationship between newborn visual fixation (VF) and gaze behavior (GB) to performance in visuomotor and visual reasoning tasks in two cohorts with cognitive follow-up at 2 (n= 57) and 5 (n= 1410) years of age. We also analyzed brain microstructural correlates to VF (n= 45) by voxel-based analysis of fractional anisotropy (FA) in newborn diffusion tensor imaging. Our results show that newborn VF is significantly related to visual-motor performance at both 2 and 5 years, as well as to visual reasoning at 5 years of age. Moreover, good newborn VF relates to widely increased FA levels across the white matter. Comparison to motor performance indicated that early VF is preferentially related to visuocognitive development, and that early motor performance relates neither to white matter integrity nor to visuocognitive development. The present findings suggest that newborn VF is supported by brainwide subcortical networks and it represents an early building block for the developmental cascades of cognition.
Pomegranate and the Mediation of Balance in Early Medicine
Authors: Ruis A. R.
Published: March 2015

Different elements of the pomegranate, both tree and fruit, had a wide range of uses in premodern therapeutics. Pomegranate also had a rich symbolic role in the art, literature, and religion of numerous cultures. In nearly every part of the globe where the pomegranate grew, it came to represent fundamental dualities: life and death, inside and out, many and one. The medicinal purposes for which healers recommended pomegranate at times reflected broader symbolic associations, and those associations are an important part of the therapeutic tradition. The dualistic symbolism that attended the pomegranate in various cultural traditions synergized with dualistic medical concepts, reinforcing the therapeutic power of pomegranate in otherwise diverse contexts. Reflecting this duality, pomegranate was both an astringent and a laxative, an emmenagogue and an antimenorrhagic, an expectorant and an antiemetic, a pyrogen and a febrifuge, a restorative and a soporific. In both literary and medical traditions, the pomegranate mediated transitions—or maintained balance—between opposing states. This essay provides an overview of the rich and sundry uses of pomegranate in premodern therapeutics, revealing how cultural associations both reflected and informed medical practices.
ENDOCRINOLOGY IN PREGNANCY: Management of the pregnant patient with a prolactinoma
Authors: Molitch Mark E
Published: March 2015

A woman with a prolactinoma is usually infertile. Dopamine agonists usually restore ovulation and fertility and such treatment generally is preferred over transsphenoidal surgery because of higher efficacy and safety. Cabergoline is usually preferred over bromocriptine because of its better efficacy with fewer adverse effects. Either drug increases the rates of spontaneous abortions, preterm deliveries, multiple births, or congenital malformations over what may be expected. However, the number of pregnancies reporting such experience is about sevenfold greater for bromocriptine. Tumor growth causing significant symptoms and requiring intervention has been reported to occur in 2.4% of those with microadenomas, 21% in those with macroadenomas without prior surgery or irradiation, and 4.7% of those with macroadenomas with prior surgery or irradiation. Visual fields should be assessed periodically during gestation in women with macroadenomas. If significant tumor growth occurs, most patients respond well to reinstitution of the dopamine agonist. Delivery of the baby and placenta can also be considered if the pregnancy is sufficiently advanced. Transsphenoidal debulking of the tumor is rarely necessary.
LĖTINĖ GRANULIOMINĖ LIGA: LITERATŪROS APŽVALGA IR KLINIKINIŲ ATVEJŲ APRAŠYMAS
Authors: Kairienė Ignė , Mulevičienė Audronė , Rimkutė Dovilė , Čerkauskienė Rimantė , Vaitkevičienė Goda , Rascon Jelena
Published: March 2015

Chronic granulomatous disease (CGD) is an inherited X-linked or, less frequently, with somatic mutations linked disorder of phagocytic cells which presents in early childhood as recurrent granulomatous lesions and atypical bacterial or fungal infections of skin, lungs, gastrointestinal tract, liver, spleen or lymph nodes. Some patients remain undiagnosed until adulthood or rarely diagnosis is made post mortem. Haematopoietic stem cell transplantation (HSCT) can cure CGD, thus timely diagnosis is essential for saving life of such patients. We present two complicated clinical cases of children with CGD, diagnosed in Lithuania for the first time. After the history of recurrent epizodes of severe infections, reviewed family history, repeated spontaneous and stimulated nitroblue tetrazolium tests (NBT), CGD diagnosis was confirmed for both patients. Allogeneic HSCT is planned in both cases expecting curative effect. All children with recurrent atypical infections should be checked for immunodeficiency. Multidisciplinary approach is essential for making rapid and correct diagnosis based on life and family history, clinical manifestation, immunologic tests and genetic counseling. CGD is curable by HSCT, thus patients should be referred to a HSCT center without delay
Acclimatization of Tapeinochilos ananassae plantlets in association with arbuscular mycorrhizal fungi
Authors: Oliveira João Ricardo Gonçalves de , Morais Thiago Alberto de Lima , Melo Natoniel Franklin de , Yano‑Melo Adriana Mayumi
Published: March 2015

The objective of this work was to assess the potential of three isolates of arbuscular mycorrhizal fungi to promote growth of micropropagated plantlets of Tapeinochilos ananassae during acclimatization. The experiment was carried out in greenhouse, in a completely randomized block design, with four inoculation treatments: non‑inoculated control and plants inoculated with Glomus etunicatum, Acaulospora longula or Gigaspora albida, with ten replicates. After 90 days, the following parameters were evaluated: survival rate, height, leaf and tiller number, leaf area, fresh and dry biomass, contents of macro‑ and micronutrients in the root and shoot, glomerospore number, and mycorrhizal colonization. The survival percentage was 100%, except for plants inoculated with G. albida (80%). The isolate G. etunicatum is more suitable for plant development, since it improves survival, growth, dry matter production, nutritional status, and vigor of T. ananassae micropropagated plants.
Thermodynamic analysis of diesel engine with sunflower biofuel
Authors: Yamık Hasan , Özel Gülcan , Açıkkalp Emin , İçingür Yakup
Published: March 2015

Thermodynamic performance, which is based on the first and second thermodynamic laws, is a significant tool to assess energy systems. In this study, the authors conducted an energy and exergy analysis of a single-cylinder, four-stroke compression ignition engine operated with sunflower methyl ester biofuel at different engine loads (20%, 40%, 60%, 80%, 100%). The energy and exergy efficiencies were subsequently calculated along with the effective work, heat exergy losses and exergy destruction values at ten different engine speeds for five loads. Finally, optimum operating conditions were defined and discussed.
THE OCCURRENCE OF THE RADIAL CLUB HAND IN CHILDREN WITH DIFFERENT SYNDROMES
Authors: Golyana Sergey Ivanovich , Avdeychik Natalia Valerievna , Safonov Andrey Valerievich , Prokopovych Vladimir Stepanovich
Published: March 2015

Radial club hand is a developmental anomaly of the upper extremity, being characterized as a longitudinal underdevelopment of a forearm and a hand on the radial surface, consisting in a hypo-/ aplazy radial bone and the thumb of various degree of expressiveness. Characteristic symptoms of this developmental anomaly are: shortening and bow-shaped curvature of a forearm, palmar and radial deviation of a hand, underdevelopment of the thumb from its proximal departments and structures, anomaly of development of three-phalanx fingers of a hand (is more often than the 2-4th), violation of a cosmetic condition and functionality of the affected segment. From 2000 for 2012 in FSI SRICO n.a. H.Turner examination and treatment of 23 children with various syndromes at which the radial club hand was revealed are conducted. The main syndromes at which it is revealed radial club hand - Holt-Orama syndrome, TAR- syndrome and VACTERL syndrome. Tactics and techniques of surgical treatment of a radial club hand it various syndromes most often don’t differ from treatment of other types of a radial club hand though demand an individual approach depending on severity and a type of deformation of the upper extremity.
SEVERE THORACOABDOMINAL TRAUMA WITH INJURY TO MAJOR VESSELS
Authors: Gumerov Aitbai Akhmetovich , Valitov Ildar Oktyabrevich , Kashaev M. R. , Zainullin Robert Ramilievich , Gumerov Ramil Aitbaevich
Published: March 2015

Thoracoabdominal trauma with injury to the great vessels is a pressing issue of urgent surgery. This paper presents the observation of the child's treatment with thoracoabdominal trauma with Thoracoabdominal trauma with injury to the great vessels is a pressing issue of urgent surgery. This paper presents the observation of the child's treatment with thoracoabdominal trauma with damage of the great vessels: clinical features, diagnosis and treatment.
FEATURES OF REHABILITATION TREATMENT IN CHILDREN WITH CONGENITAL AND ACQUIRED DISORDERS OF THE FIRST RAY OF THE HAND
Authors: Ovsyannikova Anna Dmitrievna , Golyana Sergei Ivanovich , Govorov Anton Vladimirovich
Published: March 2015

In this paper we evaluated the results of rehabilitation treatment in 55 children aged from 1 to 6 years after the following surgical treatment: pollicization of the second finger and microsurgical autografting of the second toe in the position of the thumb. A comparative analysis of standard techniques of rehabilitation treatment and the technique developed at the department was carried out. Application of individual-oriented approach depending on the functionality of the hand provided better results in rehabilitation. In the main subgroup of children after the operation of the second finger pollicization, excellent results were obtained in 11 patients (50 %), good - 9 patients (40.9 %), satisfactory - 2 patients (9.1 %). In the control subgroup, excellent results were obtained in 5 patients (20.83 %), good - in 9 (37.5 %), satisfactory - in 8 (33.33 %), poor - in 2 (8.33 %). In the group of children who underwent free autografting of toes, in the main subgroup the excellent results were obtained in 3 patients (60 %), good - in 2 patients (40 %). In the control subgroup good results were obtained in 3 patients (75 %), satisfactory - in 1(25 %). Also we revealed a correlation between the timing of the appearance of bilateral grip and functional ability of the hand in older age.
SUCCESSFUL USE OF THE PONSETI METHOD IN THE TREATMENT OF FOUR CHILDREN WITH CLUBFOOT ASSOCIATED WITH OSTEOGENESIS IMPERFECTA TYPE I
Authors: Blandinskiy Valery Fyodorovich , Vavilov Maksim Aleksandrovich , Baushev Maksim Aleksandrovich
Published: March 2015

Conservative treatment of congenital clubfoot deformity in osteogenesis imperfecta is very challenging because the high risk of pathological fracture. There is little to no data of such cases hadn’t been found to be described in the literature. We present a child with osteogenesis imperfect and clubfoot deformity, who had been previously inefficiently treated with plaster casts and developed pathological fractures of the tibia. The use of Ponseti method allowed us to completely correct the deformity and avoid complications.
TWO-STAGE TREATMENT APPROACH TO SEVERE CASES OF HIP INSTABILITY IN PATIENTS WITH INFANTILE CEREBRAL PALSY
Authors: Umnov Valery Vladimirovich
Published: March 2015

Hip instability is a common condition in patients with cerebral palsy. Its development leads to severe degenerative changes in the joint, accompanied with rapidly progressive contractures, pain, deformities of the adjacent segments and decreased limb support ability. One of the characteristic features of this disease is the development of osteochondral defect in the external part of the femoral head epiphysis. We report two clinical cases of successful two-stage surgical correction of joint elements aimed at moving the defect in the joint area, which is not loaded by the arch socket.
ANEURYSMAL BONE CYST OF THE CLAVICLE IN CHILDREN (CLINICAL CASES AND TREATMENT)
Authors: Zubairov Timur Faizovich , Bukharev Edgar Valentinovich , Zakharyan Ekaterina Anatolievna
Published: March 2015

The purpose. To examine the results of the treatment of children with aneurysmal cyst of the clavicle. Material and methods. The results of examination and treatment of patients aged 16 and 17 years with a diagnosis of aneurysmal cyst of the clavicle. All patients underwent surgical treatment with the ABC stage delimitation. We used a surgical technique, which consists in open removement of the abnormal tissue with replacement of the bone defect with bone-plastic material or autogenous bone from the iliac crest. Conclusions. The method of treatment of aneurysmal bone cyst of the clavicle must be individualized depending on the location, aggressiveness and extent of the lesion. The use bone-plastic material or autogenous bone from the iliac crest restore the structural integrity of a compromised clavicle gives good results in the observation period of up to 2 years.
SURGICAL TREATMENT OF CHILDREN WITH MADELUNG DEFORMITY
Authors: Sosnenko Olga Nikitichna , Pozdeev Alexander Pavlovich
Published: March 2015

The article presents the results of examination and treatment of 19 patients with Madelung deformity, who were treated at the department of bone pathology of the Scientific and Research Institute for Children’s Orthopedics n. a. G. I. Turner. Clinical and radiological manifestations of the disease, indications for surgery, surgical technique and results are presented.
CHRONIC TRAUMATIC DISLOCATION OF II-V METACARPAL BONES: CASE REPORT
Authors: Zavarukhin Vladimir Ivanovich , Morenko Ekaterina Sergeevna , Golyana Sergey Ivanovich , Govorov Anton Vladimirovich
Published: March 2015

Dislocations in the carpometacarpal joints of three-phalanx fingers are rare form of injury. Their clinical manifestations are often veiled by swelling, and radiographs in standard views provide little information, which leads to difficulty in diagnosis and a high incidence of unidentified dislocations in the primary treatment. The article describes the basic provisions of the diagnosis and treatment of this type of injury, a clinical case of surgical treatment of undiagnosed dislocations of II-V metacarpal bones in the acute period, and long-term results of treatment.
Relative effects of landscape‐scale wetland amount and landscape matrix quality on wetland vertebrates: a meta‐analysis
Authors: Quesnelle Pauline E. , Lindsay Kathryn E. , Fahrig Lenore
Published: March 2015

Conservation management of wetland‐dependent species generally focuses on preserving or increasing wetland habitat. However, the quality of the landscape matrix (the intervening non‐wetland portion of the landscape) has been shown to be more important than wetland availability for some wetland‐dependent species. We used meta‐analysis to compare the effects of wetland amount (measured as the area of wetland habitat in a landscape) and matrix quality (measured as the area of forest cover in the same landscape) on the population abundance of wetland‐dependent vertebrates. We combined data across 63 studies conducted in forested ecoregions worldwide and extracted 330 population responses for 155 species, at the spatial scale that best predicted the effects of wetland amount and forest amount for each response. In addition, to ensure that our results were not biased by the scale selected, we assessed whether the relative effects of wetland and forest amount were scale dependent. We found that the amount of wetland in a landscape had a larger effect than the amount of forest on the abundance of mammals and birds whereas, surprisingly, for amphibians the amount of forest in a landscape was more important than the amount of wetland. For reptiles, both wetland amount and forest amount showed only weak effects on abundance. These results were not scale dependent, i.e., they were consistent across spatial scales. Our results suggest that the population distribution of wetland‐dependent amphibians is more strongly related to landscape matrix quality than to wetland availability in a landscape, likely due to their requirement for access to terrestrial resources. We conclude that conservation policies for wetland biodiversity that focus only on wetland habitat will be ineffective in conserving many of these species. In addition, population viability analyses based only on wetland amount may overestimate the capacity of a landscape to support populations of wetland‐dependent species.
Predator cannibalism can intensify negative impacts on heterospecific prey
Authors: Takatsu Kunio , Kishida Osamu
Published: March 2015

Although natural populations consist of individuals with different traits, and the degree of phenotypic variation varies among populations, the impact of phenotypic variation on ecological interactions has received little attention, because traditional approaches to community ecology assume homogeneity of individuals within a population. Stage structure, which is a common way of generating size and developmental variation within predator populations, can drive cannibalistic interactions, which can affect the strength of predatory effects on the predator's heterospecific prey. Studies have shown that predator cannibalism weakens predatory effects on heterospecific prey by reducing the size of the predator population and by inducing less feeding activity of noncannibal predators. We predict, however, that predator cannibalism, by promoting rapid growth of the cannibals, can also intensify predation pressure on heterospecific prey, because large predators have large resource requirements and may utilize a wider variety of prey species. To test this hypothesis, we conducted an experiment in which we created carnivorous salamander (Hynobius retardatus) populations with different stage structures by manipulating the salamander's hatch timing (i.e., populations with large or small variation in the timing of hatching), and explored the resultant impacts on the abundance, behavior, morphology, and life history of the salamander's large heterospecific prey, Rana pirica frog tadpoles. Cannibalism was rare in salamander populations having small hatch‐timing variation, but was frequent in those having large hatch‐timing variation. Thus, giant salamander cannibals occurred only in the latter. We clearly showed that salamander giants exerted strong predation pressure on frog tadpoles, which induced large behavioral and morphological defenses in the tadpoles and caused them to metamorphose late at large size. Hence, predator cannibalism arising from large variation in the timing of hatching can strengthen predatory effects on heterospecific prey and can have impacts on various traits of both predator and prey. Because animals commonly broaden their diet as they grow, such negative impacts of predator cannibalism on the heterospecific prey may be common in interactions between predators and prey species of similar size.
The long decade of digital preservation in heritage institutions in the Czech Republic: 2002â€“2014
Authors: HutaÅ™ Jan , Melichar Marek
Published: March 2015

This paper aims to give state-of-the-art information about digital preservation activities in the Czech Republic during the last decade to an English-speaking audience. We briefly describe major phases of the â€œdigitalâ€ projects. These were mainly in libraries, with some references to museums, galleries and archives. We focus on aspects related to the preservation of collected born-digital and digitised content. Even now, digital preservation activities in heritage institutions are often on the periphery of the interest of all stakeholders and the infrastructure supporting digital preservation of data in heritage institutions is not well financed or coordinated. Even though the â€œlong decadeâ€, which lasted from the dramatic events of 2002 until approximately 2014, saw a number of successful projects creating digital data in Czech libraries, the handful of projects which were in part focused on digital preservation were not flexible enough to accommodate user requirements and were failing to meet expectations. There is still much room for further development in the area of long-term preservation of digital data in the Czech Republic. This article is a shortened version of one of the analyses written under the â€œStrategy of the research, development and innovation for the years 2010â€“2015â€ program of the Moravian Library in Brno, Czech Republic.
The impact of isatin derivatives on antibiotic production by Streptomyces hygroscopicus CH-7
Authors: Ciric Jovan , Konstantinovic Sandra , Ilic Slavica , Gojgic-Cvijovic Gordana , Savic Dragisa , Veljkovic Vlada
Published: March 2015

The effect of isatin derivatives as a nitrogen source on antibiotic (Hexaene
H-85 and Azalomycine B) production by Streptomyces hygroscopicus CH-7 was
studied. Isatin-3-hydrazone, 5-chloroisatin-3-hydrazone,
isatin-3-tosylhydrazone, 5-chloroisatin-3-tosylhydrazone,
isatin-3-(4`-hidroxy)benzoilhydrazone and
5-chloroisatin-3-(4`-hidroxy)benzoilhydrazone were synthesized in a crude
glycerol, obtained during the biodiesel production from edible sunflower oil.
The highest concentration of Hexaene H-85 is achieved with
5-chloroisatin-3-hydrazone (197 mg/cm3) in medium, while isatin-3-hydrazone
has a greatest impact on Azalomycine B production (72 ?g/cm3).
Manganese-Mediated MRI Signals Correlate With Functional β-Cell Mass During Diabetes Progression
Authors: Meyer Anke , Stolz Katharina , Dreher Wolfgang , Bergemann Jennifer , Holebasavanahalli Thimmashetty Vani , Lueschen Navina , Azizi Zahra , Khobragade Vrushali , Maedler Kathrin , Kuestermann Ekkehard
Published: March 2015

Diabetes diagnostic therapy and research would strongly benefit from noninvasive accurate imaging of the functional β-cells in the pancreas. Here, we developed an analysis of functional β-cell mass (BCM) by measuring manganese (Mn2+) uptake kinetics into glucose-stimulated β-cells by T1-weighted in vivo Mn2+-mediated MRI (MnMRI) in C57Bl/6J mice. Weekly MRI analysis during the diabetes progression in mice fed a high-fat/high-sucrose diet (HFD) showed increased Mn2+-signals in the pancreas of the HFD-fed mice during the compensation phase, when glucose tolerance and glucose-stimulated insulin secretion (GSIS) were improved and BCM was increased compared with normal diet–fed mice. The increased signal was only transient; from the 4th week on, MRI signals decreased significantly in the HFD group, and the reduced MRI signal in HFD mice persisted over the whole 12-week experimental period, which again correlated with both impaired glucose tolerance and GSIS, although BCM remained unchanged. Rapid and significantly decreased MRI signals were confirmed in diabetic mice after streptozotocin (STZ) injection. No long-term effects of Mn2+ on glucose tolerance were observed. Our optimized MnMRI protocol fulfills the requirements of noninvasive MRI analysis and detects already small changes in the functional BCM.
Thermodynamic evaluation of supercritical oxy-type power plant with high-temperature three-end membrane for air separation
Authors: Kotowicz Janusz , Balicki Adrian , Michalski Sebastian
Published: March 2015

Among the technologies which allow to reduce greenhouse gas emissions, mainly of carbon dioxide, special attention deserves the idea of ‘zero-emission’ technology based on boilers working in oxy-combustion technology. In the paper a thermodynamic analysis of supercritical power plant fed by lignite was made. Power plant consists of: 600 MW steam power unit with live steam parameters of 650 °C/30 MPa and reheated steam parameters of 670 °C/6 MPa; circulating fluidized bed boiler working in oxy-combustion technology; air separation unit and installation of the carbon dioxide compression. Air separation unit is based on high temperature membrane working in three-end technology. Models of steam cycle, circulation fluidized bed boiler, air separation unit and carbon capture installation were made using commercial software. After integration of these models the net electricity generation efficiency as a function of the degree of oxygen recovery in high temperature membrane was analyzed.
Thermo-economic comparative analysis of gas turbine GT10 integrated with air and steam bottoming cycle
Authors: Czaja Daniel , Chmielnak Tadeusz , Lepszy Sebastian
Published: March 2015

A thermodynamic and economic analysis of a GT10 gas turbine integrated with the air bottoming cycle is presented. The results are compared to commercially available combined cycle power plants based on the same gas turbine. The systems under analysis have a better chance of competing with steam bottoming cycle configurations in a small range of the power output capacity. The aim of the calculations is to determine the final cost of electricity generated by the gas turbine air bottoming cycle based on a 25 MW GT10 gas turbine with the exhaust gas mass flow rate of about 80 kg/s. The article shows the results of thermodynamic optimization of the selection of the technological structure of gas turbine air bottoming cycle and of a comparative economic analysis. Quantities are determined that have a decisive impact on the considered units profitability and competitiveness compared to the popular technology based on the steam bottoming cycle. The ultimate quantity that can be compared in the calculations is the cost of 1 MWh of electricity. It should be noted that the systems analyzed herein are power plants where electricity is the only generated product. The performed calculations do not take account of any other (potential) revenues from the sale of energy origin certificates. Keywords: Gas turbine air bottoming cycle, Air bottoming cycle, Gas turbine, GT10
Existence of Ψ Bounded Solutions for a Lyapunov Matrix Dierential Equation
Authors: Diamandescu Aurel
Published: March 2015

It is proved a necessary and sufficient condition for the existence of at least one Ψ- bounded solution of a linear non- homogeneous Lyapunov matrix differential equation. In addition, it is given a result in connection with the asymptotic behavior of the Ψ- bounded solutions of this equation.
Sur l’unicité de la forme des factorisations de longueur maximale d’une extension purement inséparable finie
Authors: Fliouet El Hassane
Published: March 2015

Let K/k be a finite purely inseparable extension of field k of characteristic p > 0. A factorization of length m of K/k is the data of m intermediate fields K