bluuebunny/crossref_metadata_2025 huggingface dataset:
Tatwir Wasilah Sparkol Videoscribe Fi at Tadris al Qowaid an Nahwiyah
Authors: Habib  , Zamakhsyari bin Hasballah Thaib  , Afandi Ahmad
Published: July 2023

الهدف من هذا البحث لتطوير وسيلة ‎ Sparkol Videoscribeفي تدريس القواعد النحوية ولمعرفة مدى فعالية تطوير وسيلة Sparkol Videoscribe في تدريس القواعد النحوية. أما طريقة البحث التي يستخدمها الباحث هي طريقة البحث والتطوير (Research and Development) للبحث الميداني مع نموذج ADDIE (التحليل والتصميم والتطوير والتنفيذ والتقييم). نتائج تجربة تطوير وسائل Sparkol Videoscribe لديها معدل صلاحية 93٪ من خبراء المواد، و 67٪ من خبراء الإعلام، و 84٪ من خبراء التعلم الأول، و 97٪ من خبراء التعلم الثاني، لذلك يمكن الاستنتاج أن المنتجات الإعلامية التي تم تطويرها مجدية / صالحة ويمكن تنفيذها في هذا المجال، أي في طلاب الصف العاشر في مدرسة الثانوية الإسلامية الحكومية 2 ميدان. بلغ متوسط الفرق في نتائج تعلم الطلاب 82،3529 فئة التحكم و 91،7647 فئة تجريبية ونتائج تحليل اختبار t تبين أن عدد t = 0،044 أصغر من جدول t = 0،05. من النتائج التي تم الحصول عليها، فإنه يظهر أن المنتجات التي تم تطويرها يمكن أن تؤثر على نتائج التعلم لطلاب الصف العاشر من مدرسة الثانوية الإسلامية الحكومية 2 ميدان. وبالتالي فإن وسائلSparkol Videoscribe  مناسبة لتعلم اللغة العربية في مادة القواعد النحوية.
FOTOEXPOSIÇÃO EM AGENTES COMUNITÁRIOS DE SAÚDE NO MUNICÍPIO DE VASSOURAS - RJ: PRIMEIRA ANÁLISE DE CAMPO
Authors: Guimarães Ana Luiza Cardoso , Oliveira Flávia Pina Siqueira Campos de , Azevedo Mariana Luíza Ferreira de , Rocha Cristiane de Souza Marques
Published: July 2023

A pele reveste o corpo humano e torna-se sujeita a diferentes tipos de lesões, sendo que a grande maioria delas são provocadas por exposição solar contínua e progressiva. Os profissionais que exercem seu trabalho em ambiente externo, como os Agentes Comunitários de Saúde (ACS), estão mais sujeitos aos danos ocasionados pela radiação ultravioleta (UV), principalmente aqueles que negligenciam os fatores protetores. Objetivo: conhecer os hábitos de exposição solar dos ACS que atuam nas 21 Unidades Básicas de Saúde do município de Vassouras, Rio de Janeiro. Métodos: trata-se de um estudo quantitativo, realizado no período entre agosto de 2020 e agosto de 2022, com a obtenção de informações através de questionários estruturados com 41 ACS. Resultados: 80% das ACS realizam visitas mais de 4 vezes na semana, com uma exposição média de mais 4 horas diárias, sendo que dessas foi superior a 50% os indivíduos que se expõem entre 10:00 hrs e 14:00 hrs. 71% dos pesquisados relatam já ter apresentado alguma história de queimadura solar durante a vida. Das ACS apenas 41% afirmam utilizar filtro solar com frequência, dessas 56% utilizam apenas no verão. 68% não usam outros mecanismos de fotoproteção além do filtro solar. Conclusão: Esses dados permitem orientar medidas coletivas para prevenção de lesões dermatológicas.
АВТОМОБИЛЬДЕРДІҢ ЖҰМЫСЫН БАСҚАРУ ЖҮЙЕСІ МОДЕЛІНІҢ ПАРАМЕТРЛЕРІ МЕН БАРАБАРЛЫҒЫН АНЫҚТАУ ӘДІСТЕМЕСІ
Authors: Нұғыманова Гүлдана
Published: July 2023

Автокөлікті басқару жүйесін басынан аяғына дейін жиналған тізбектермен және белгілі бір экономикалық қатынастармен сыртқы байланысы жоқ шеңбер деп атауға болады. Автокөлік құралдарын пайдаланудың ұқсас процестерінде оларды басқару жүйесінің шеңбері ретінде бөлек қарастыруға болады. Ол үшін белгілі бір кезеңде әртүрлі әсерлерден пайда болатын динамикалық өзгерістерді анықтау қажет. Нақты нәтижелерге қол жеткізу үшін, орындалған тапсырыстардың сапасына байланысты, белгілі бір уақыт аралығында қызметтердің орындалған және жоспарланған көлеміне байланысты талдау жүргізу қажет.
PENGARUH ECONOMIC VALUE ADDED, MARKET VALUE ADDED, NILAI PASAR, AKTIVITAS, DAN PROFITABILITAS TERHADAP RETURN SAHAM PADA PERUSAHAAN SUBSEKTOR FARMASI DAN RISET KESEHATAN YANG TERDAFTAR DI BEI
Authors: Hidayat Randy , Juwita Permata Sari  , Fadil Yamaly  , Eni Cahyani
Published: July 2023

This study aims to determine the effect of economic value added, market value added, market value, activity, and profitability on stock returns in pharmaceutical and health research sub- companies listed on the IDX. In this study, there were 8 samples of companies in the Pharmaceutical and Health Research Subsector in the 2017-2021 period using a purposive sampling method. The data analysis technique used is quantitative analysis. Then statistical analysis is carried out using Multiple Linear Regression and Hypothesis Testing which includes the F test and t test. The results of this study indicate that there is a significant effect of Economic Value Added, Market Value Added, Market Value, Activity, and Profitability together on Stock Returns. Based on the partial test, there is a significant influence on Market Value, Activity and Profitability. Meanwhile, Economic Value Added and Market Value Added have no significant effect on Stock Returns in Health Research and Health Research Subsector Companies Registered on the IDX.
Abstrak
Penelitian ini bertujuan untuk mengetahui Pengaruh Pengaruh Economic Value Added, Market Value Added, Nilai Pasar, Aktivitas, dan Profitabilitas Terhadap Return Saham Pada Perusahaan Subsektor Farmasi dan Riset Kesehatan yang Terdaftar di BEI. Dalam penelitian ini terdapat 8 sampel perusahaan Subsektor Farmasi dan Riset Kesehatan pada periode 2017-2021dengan menggunakan metode purposive sampling. Teknik analisis data yang digunakan adalah analisis kuantitatif. Kemudian dilakukan analisis statistik dengan menggunakan Regresi Linear Berganda dan Uji Hipotesis yang meliputi Uji F dan Uji t. Hasil penelitian ini menunjukkan bahwa ada pengaruh signifikan Economic Value Added, Market Value Added, Nilai Pasar, Aktivitas, dan Profitabilitas secara Bersama-sama terhadap Return Saham. Berdasarkan uji parsial ada pengaruh signifikan Nilai Pasar, Aktivitas, dan Profitabilitas. Sedangkan Economic Value Added, Market Value Added tidak berpengaruh signifikan terhadap Return Saham Pada Perusahaan Subsektor Farmasi dan Riset Kesehatan yang Terdaftar di BEI.
A ocorrência de infecção por COVID-19 em pacientes assintomáticos na testagem pré-operatória
Authors: Uchiya Eduardo Haruo , Desordi Lobo Renata , Sousa Cristina Silva
Published: July 2023

Objetivo: Analisar a ocorrência de pacientes cirúrgicos assintomáticos com teste para COVID-19 positivo, delimitar o perfil epidemiológico, identificar o tipo de cirurgia e a especialidade, bem como determinar o tempo de execução do procedimento cirúrgico após testagem positiva. Método: Trata-se de um estudo de coorte retrospectiva, em um hospital de grande porte, filantrópico, de São Paulo, realizado no período de março a setembro de 2020, baseado na análise de dados de prontuário. Resultados: Foram 4.870 procedimentos cirúrgicos, dos quais 3.688 pacientes tiveram coleta de exame PCR. A ocorrência de pacientes cirúrgicos positivos e assintomáticos foi de 1,7%; no perfil epidemiológico, observa-se predominância de sexo masculino, meia-idade, com classificação de risco anestésico ASA II e em procedimentos das especialidades de ortopedia, urologia, ginecologia e gastroenterologia. A execução do teste foi de dois dias pré-procedimento e a presença de pacientes com sintomas em até 14 dias após testagem foi de 0,5%. Conclusão: A ocorrência de pacientes cirúrgicos positivos e assintomáticos foi pequena dentro do quantitativo analisado, os achados deste estudo são similares aos de estudos nacionais e internacionais em relação a especialidade, comorbidades e idade.
Geotechnological regulation of the development of oil fields with hard-to-recover reserves
Authors: Sultanov Shamil K. , Malyarenko Alina M.
Published: July 2023

Background: A significant proportion of the remaining oil reserves of the fields under development is confined to reservoir zones with low-permeability and undersaturated reservoir, thin reservoirs. Maintenance of oil production levels in such deposits is possible through methodological study and development of recommendations for optimizing and improving the development system, targeted application of technologies and methods for enhanced oil recovery. In turn, the methodological study for deposits with hard-to-recover reserves includes a systematic statistical and geological and technological analysis of the results of field development, an analysis of existing generally accepted methodologies, and theoretical studies. Thus, the creation of an integrated approach to regulating the development of oil fields, taking into account a detailed understanding of the geological structure, is an important task in the current state of the fields under development.
Aim: The aim of the work is to develop an integrated approach to regulating the development of oil fields with hard-to-recover reserves based on methodological solutions of technological and statistical analysis, differentiation of research objects, retrospective analysis of the use of technologies and methods aimed at increasing oil recovery. The aim of the work is to form an integrated approach to regulating the development of oil fields with hard-to-recover reserves based on methodological solutions for geological-technological and geological-statistical analysis, differentiation of research objects, retrospective analysis of the use of technologies and methods aimed at increasing oil recovery.
Materials and methods: Achieving this goal is possible using the following methods: statistical analysis, geological and field analysis, methodological solutions for studying the relationship "rock fluid", differentiation of research objects according to geological, geophysical and geological and field data. On the example of some stages, research algorithms are proposed.
Results: A methodological solution is proposed for regulating the development of oil fields with hard-to-recover oil reserves.
Conclusion: The proposed geotechnological approach to the development control will improve the technological efficiency of hydrocarbon reserves development due to a detailed understanding of the reservoir structure, differentiation into zones (areas) of the reservoir, study and analysis of their state of development, reasonable selection of priority and promising technologies and technical solutions to increase their production.
Study of the pore structure and calculation of macroscopic characteristics of rocks based on X-ray microcomputed tomography images
Authors: Bolysbek Darezhat A. , Kulzhabekov Alibek B. , Bekbau Bakbergen Y. , Uzbekaliyev Kenboy S.
Published: July 2023

Background: Absolute and relative phase permeability and capillary pressure are important parameters in predicting oil and gas production from reservoirs, especially when acidizing the bottomhole zone of a well. They are mainly determined during long and resource-intensive laboratory experiments. Thus, additional approaches are required for the operational determination of the above parameters. The pore-network modeling based on microcomputed tomography data allows, firstly, to study the pore space of rock samples taking into account rock dissolution, secondly, to calculate the main macroscopic properties of rock samples without destroying them, and thirdly, to create a database of digital cores for further research
Aim: Study of the pore space of two carbonate rock samples and the flow of fluids in them using the General Electric V|tome|X S240 MT and using the Avizo and PNFLOW software package.
Materials and methods: This article uses microcomputed tomography with a spatial resolution of ~19 m and pore-network modeling of fluid flow in porous media to study the pore space of carbonate rock samples and determine absolute and phase permeabilities, as well as capillary pressure.
Results: It is shown that an increase in the value of the Marker Extent parameter leads to a decrease in the number of pores and an overestimated absolute permeability due to improper pore separation, while a decrease in the value of this parameter made it possible to identify smaller pores. It is also shown that absolute permeability and porosity have different relationships before and after rock dissolution with high correlation coefficients that range from 0.62 to 0.81. It has been shown that rock dissolution will significantly affect the relative phase permeability of the samples.
Conclusion: The dissolution of the rock led to a decrease in the residual oil saturation in both samples. In the case of oil displacement by water, as a result of rock dissolution, the residual oil saturation decreased from 38% to 22% and from 53% to 43% for the two samples under study. These results are important for understanding the flow of fluids in carbonate samples.
Hydraulic fracturing using high-boiling fraction of oil as a fracturing fluid
Authors: Mashrapova Moldir A. , Tileuberdi Nurbol , Abdeli Dairabay Zhumadiluly , Ozdoyev Sultan M. , Iskak Ardak S.
Published: July 2023

Background: In recent years, there has been a trend towards deterioration in the structure of residual reserves at the fields of Kazakhstan. A significant part of the reserves is located in low-permeability reservoirs and in the zones not covered by flooding. The main factor negatively affecting the productivity and efficiency of development is the heterogeneity of oil reservoirs.
Oil-saturated formations are an alternation of permeable oil-saturated sand or limestone and impermeable clay or dolomite layers, lenses and interlayers. Up to 1020 interlayers can be distinguished within the reservoir, which indicates a strong compartmentalization of the reservoirs. Due to the complexity of the structure of oil deposits, it is very difficult or impossible to ensure complete drainage of the entire volume of the deposit and complete coverage of oil displacement by water into production wells through injection wells.
Aim: Increasing oil recovery in a cost-effective way.
Materials and methods: Experimental studies of the processes of impact on the bottomhole formation zone with high-boiling oil components were carried out using a laboratory machine for diamond drilling, an installation for determining the permeability of a rock in terms of liquid and gas, an installation for determining oil viscosity, and an installation for pumping fracturing fluid into the reservoir model.
Results: As a result of applying the hydraulic fracturing method using high-boiling oil components, it is possible to increase the permeability of low-permeability formations and significantly increase oil recovery.
Conclusion: Due to the geological structure of multi-layer oilfields, water-based gel fracturing fluids to increase oil flow to wells are considered ineffective due to the adsorption of gels with long molecules in the pores of the formation and swelling of the clay particles of the reservoir when they interact with the water-based fluid.
Prospects for the use of energy-accumulating substances in solving environmental problems in the oil industry
Authors: Boiko Galina I. , Sarmurzina Raushan G. , Galieva Nina P. , Karabalin Uzakbay S. , Tiessov Daniyar S. , Akhanova Tanzilya R. , Kenyaikin Pavel V.
Published: July 2023

The prospects for using new-generation energy-accumulating substances based on aluminum alloys activated with activating metals (indium, gallium, tin, eutectics of low-melting metals) as non-traditional environmentally friendly sources for hydrogen production from water and energy accumulation methods, the formation of various forms of aluminum hydroxides, are discussed, which can be used in solving environmental problems in the oil industry: in technologies for complex oil treatment, destruction of abnormally stable water-oil emulsions and oil sludge, demetallization and desulphurization of hydrocarbon raw materials, for the treatment of industrial waste, recycled and natural waters, as well as the reclamation of oil-contaminated areas with low and average levels of pollution, restoration of their fertility when used together with organomineral (humic) fertilizers.
ON THE QUESTION OF THE PECULIARITIES OF INVESTIGATIVE ACTIONS INVOLVING MINORS
Authors: Малыхина Татьяна А.
Published: July 2023

Вопросы, связанные с производством следственных действий и тактикой расследования уголовных дел с участием несовершеннолетних, являются актуальными. Фигура несовершеннолетнего участника уголовного судопроизводства содержит в себе множество спорных аспектов с точки зрения уголовно-процессуальной науки. Уголовное судопроизводство по делам в отношении несовершеннолетних имеет свои особенности и определенные сложности. В статье обозначена важность специфического подхода к производству следственных действий с участием несовершеннолетних. Автором изучены некоторые проблемные моменты, возникающие в процессе участия несовершеннолетнего в уголовном судопроизводстве. В статье выделены основные проблемы, связанные с тактикой расследования уголовных дел с участием несовершеннолетних, на стадии предварительного расследования при проведении следственных действий.

Issues related to the production of investigative actions and the tactics of in-vestigating criminal cases involving minors are relevant. The figure of a minor participant in criminal proceedings contains many controversial aspects from the point of view of criminal procedure science. Criminal proceedings in cases involving minors have their own characteristics and certain difficulties. The article indicates the importance of a specific approach to the production of investigative actions involving minors. The author has studied some problematic points that arise in the process of participation of a minor in criminal proceedings. The article highlights the main problems associated with the tactics of investigating criminal cases involving minors at the stage of prelimi-nary investigation during investigative actions.
تنفيذ البرنامج الإعدادي لمسابقة قراءة الكتب في معهد سومطرى طواليب بارابك بوكيت تينجي
Authors: Rahmi Hafizatur , Zamani Athira Fakhriatuz , Latifi Lutfia Nasrul
Published: July 2023

The purpose of this study was to describe implementation of the Musabaqah Qiro'atul Pole program at the Sumatra Thawalib Islamic Boarding School Parabek Bukittinggi, West Sumatra in preparing students to prepare for Qiroatul Pole competitions in various competitions, to improve quality in reading Arabic books and to preserve the culture in Islamic boarding schools that we know is identical with the study of classic books and so that we can maintain and develop the basic values of students, especially at the Sumatra Thawalib Parabek Islamic boarding school, Bukittinggi, West Sumatra. This study used a qualitative approach with a case study type. Data collection techniques were in the form of interviews and documentation, as well as data sources in the form of documents and informants related to extracurriculars, especially MQK Takhassus. The results of this study are that the Sumatra Thawalib Parabek Islamic Boarding School, Bukittinggi, West Sumatra runs the Takhassus MQK Program which is guided by a special coach by carrying out the Takhassus MQK program every day, which provides preparations for students to take part in competitions.
CADASTRO ÚNICO NO MUNICÍPIO DE PRESIDENTE KENNEDY - ES: DIÁLOGOS SOBRE AS INTERFACES EMERGIDAS COM A PANDEMIA COVID-19
Authors: Rissi Juliete
Published: July 2023

O presente artigo apresenta as principais características do Cadastro Único e seus programas de realce, o Programa Bolsa Família e o Programa Auxílio Brasil. Programas estes, que se configuram instrumentos estratégicos e permeiam o acesso da população a políticas públicas. O estudo propõe uma análise de índices e dados no município de Presidente Kennedy – ES, concentrando-se em períodos que antecedem o momento de surgimento da pandemia COVID 19, em consonância com índices apresentados no pós-pandemia. Além de discorrer sobre as condicionalidades dos programas e o balanço periódico de quantitativo de famílias inscritas, foram frisados dados relevantes sobre o índice de famílias que buscaram apoio em políticas públicas durante e após a pandemia no município que apresenta o maior PIB per capito nacional. A pesquisa foi realizada mediante procedimento de análise documental, tendo como ênfase dados fornecidos pelo Instituto Brasileiro de Geografia, o sistema CECAD, o Guia de Gestão do Programa Auxílio Brasil e o portal do Ministério da Cidadania.
Réalisme magique et réalisme merveilleux : autour de quelques enjeux terminologiques depuis Alejo Carpentier
Authors: Besand Vanessa
Published: July 2023

L’expression européenne de « réalisme magique » (1925) a été concurrencée par celle de « real maravilloso », définie par Alejo Carpentier (1949). Derrière ce changement de terminologie se cache toute une stratégie rhétorique, destinée à lier la notion au territoire américain au détriment de l’Europe. Il s’agira de s’intéresser de près à sa mise en place, en observant, à travers les ressorts davantage affectifs qu’intellectuels qui la sous-tendent, son lien à une forme d’hystérisation, mais aussi de voir comment elle a marqué durablement les approches théoriques relevant du réalisme magique.
« C’est une pie, enculé ! ». Expressions virales de l’hystérisation sur les réseaux sociaux
Authors: Bajríc Samir , Monin Isabelle , Saulan Dubravka
Published: July 2023

« C’est une pie enculé / putain de citadin de ses morts ». C’est ainsi qu’un certain Kevin est devenu célèbre malgré lui, à la suite de deux commentaires successifs sous la publication d'un groupe tout à fait banal d'entraide entre particuliers sur Facebook. Cette expressivité immédiate questionne la dimension linguistique de la liberté d'expression, dans un espace qui permet d’alimenter la maladie récemment nommée hystérisation : de l’enthousiasme aux insultes, de nombreux faits de langues nourrissent ces formes de subjectivité, à l’intérieur de l’écosystème énonciatif du discours numérique.
Satire, polémique, hystérie : Nicolas Bourbon (Nugae, 1533) et ses ennemis
Authors: Laigneau-Fontaine Sylvie
Published: July 2023

L’humaniste Nicolas Bourbon est un membre important du réseau évangélique français, dont l’œuvre est caractérisée par une forte dimension polémique : prises à partie d’une violence extrême des « jaloux » qui envient ses succès mais, surtout, attaques ad hominem contre les ennemis des humanistes, d’Erasme en particulier, avec des arguments qui ne doivent rien à la réalité (stupidité du grand savant Diego Lópe Zúñiga, débauche du moine chartreux Pierre Cousturier) et tout à l’hystérisation de querelles qui, bientôt, devaient ne plus se régler par les mots, mais par les armes.
Faktor Penyebab dan Penegakan Hukum Kenakalan Remaja: Studi Fenomena Geng Sekolah di Kota Kupang
Authors: Sarlince Muskanan Mevi , Petrus Leo Rudepel , G. Manuain Orpa
Published: July 2023

Setiap hari ada saja media yang menayangkan kasus-kasus perkelahian antar SMA yang berkaitan dengan tindak kekerasan bisa terjadi di kalangan pelajar di Kota Kupang terutama yang nota bene nya adalah generasi bangsa. Dadang Hawari mengatakan bahwa suatu perbuatan dikatakan nakal apabila melanggar atau menyimpang dari norna agama, sekolah dan masyarakat. Hasil penelitian yang telah di publikasikan ini belum pernah di teliti sebelumnya di lingkungan Fakultas Hukum Universitas Nusa Cendana meskipun demikian di dalamnya tidak terdapat kesamaan. Hasil penelitian menunjukkan: (1) Faktor penyebab dan penegakan hukum kenakalan remaja: Studi Fenomena Geng Sekolah Di Kota Kupang: (a) Faktor Internal (dari dalam diri): pertama, untuk kecendurungan memuaskan keserakahan, kedua Meningkatkan agresivitas dan dorongan seksual, ketiga hasrat untuk berkumpul dengan teman sebaya, (b) Faktor eksternal (dari luar diri): pertama, kondisi keluarga yang berantakan, Status ekonomi keluarga yang rendah, salah asuh dan salah didik orang tua, lingkungan sekolah, Kedua sekolah menempuh cara:  Mengubah para digma yang salah dalam keluarga dan sekolah, memberikan kesempatan dialog antar remaja, orang tua, pendidik dan masyarakat, tegas pada komite penyiaran Indonesia KPI, instansi sosialisasi berupa kampanye, pidato kekerasan pada anak harus di hentikan, Memberikan pendidikan karakter di sekolah karena sekolah lebih mementingkan aspek kognitif. ketiga Kepolisian sudah menempuh langkah-langkah pencegahan: Upaya Penal, Upaya non penal. (2) Implementasi penegakan hukum terhadap kenakalan remaja (geng sekolah) di Kota Kupang, implementasi hukum sendiri untuk DL merokok di kelas yang di atur dalam Pasal 5 Ayat 1, menghamili pacar Pasal 76D Undang-undang Perlindungan Anak mengatur soal pemaksaaan mengancam anak untuk melakukan persetubuhan.
BOSNIA AND HERZEGOVINA’S PEACEKEEPERS ON AFRICAN SOIL DURING COVID-19: PROCEDURES, CHALLENGES AND LESSONS
Authors: Sikimić Milica , Vujanović Bojan
Published: July 2023

Abstract: Active United Nation missions on African soil are: MINURSO in Western Sahara,  UNMISS in South Sudan, MINUSMA in Mali, MONUSCO in Democratic Republic of the Congo, MINUSCA in Central African Republic and UNISFA in Abyei. Peacekeeping has always been highly dynamic and has evolved in the face of new issues. But, in addition to the challenges they face while assisting host countries on the difficult path from conflict to peace, peacekeepers have recently had to deal with procedures and obstacles caused by the global COVID-19 pandemic. The aim of the article is to investigate the performance of everyday tasks in the COVID-19 era with an emphasis on issues related to the availability of basic supplies for UN peacekeepers, personal protective equipment, medical services, welfare, travel restrictions, and connections with the resident population in Africa. In this paper, we will present the results of qualitative research (in-depth interviews) on the experiences of UN staff from Bosnia and Herzegovina (BiH) who served in the mission in South Sudan (UNMISS), in the period 2020-2022. In anticipation of malaria, typhoid, hepatitis, salmonella, etc., the peacekeepers faced a new unknown disease, a shortage of medicines, they had no access to hospitals, and personal protective masks were made from their underwear. In some areas the local population believed that COVID19 was a “mysterious disease” brought and spread by peacekeepers and this fact shed new light on (non)cooperation with UN staff. Apart from the UN, the mission staff were (not) provided with support and assistance in various ways by the countries which they came from.
La vigilancia electrónica y su incidencia en la vulneración del derecho a la no discriminacion en el penal de Santa Mónica-Chorrillos 2020-2021
Authors:   , Aspajo Acosta Rubí , Escalante Montjoy Nilda Alicia
Published: July 2023

Nuestro presente trabajo de investigación, Titulada La Vigilancia Electrónica y su incidencia en la vulneración del derecho a la no discriminación en el penal de Santa Mónica- Chorrillos 2020-2021, nos ha permitido realizar un análisis basado en estadísticas, las mismas que hay sido elaboradas a través de método de las encuestas entre la población penitenciaria del penal de Santa Mónica. Teniendo como objetivo principal identificar como el acceso a la vigilancia electrónica vulnera el derecho a la no discriminación. El método explicativo – descriptivo el cual utilizamos dentro de nuestro trabajo de investigación a través del cuestionario para así obtener la información clara y precisa en este año 2020-2021. Respecto de nuestros resultados a través de la elaboración del cuestionario el cual consta de 15 preguntas, logrando obtener 41 respuestas mediante la aplicación del whatsapp; de ello se puede evidenciar que la falta de política de estado respecto al acceso de internet vulnera el derecho a la no discriminación. Finalmente podemos llegar a la conclusión cuán importante es que el estado implemente y priorice como política publica el acceso de conectividad a través del internet para la población en general; de esta forma resolver las limitaciones de internet y así permitir que el acceso de la vigilancia electrónica en espacio y tiempo sea accesible a las condenas y procesadas de recursos socio-económico bajos y así no vulnerar el derecho a la no discriminación.
Antibacterial Activity of n-Hexane Dragon’s Blood Resin Extract (Daemonorops draco wild Blume) from Bener Meriah, Aceh Province, Indonesia
Authors: Khairan Khairan , Arini Musfira , Idroes Rinaldi , Awang Khalijah , Jacob Claus
Published: July 2023

The dragon’s blood resin (Daemonorops draco wild Blume) has been used in folk medicine for pharmacological activities such as antimicrobial, antivirus, anti-inflammation, gastrointestinal disorders, blood circulation dysfunctions, antitumor, and cancer. This study was designated to evaluate the antibacterial activity of n-Hexane dragon’s blood resin extract against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Candida albicans 10231. The other purpose of this study was to determine the secondary metabolites compound of n-Hexane dragon’s blood resin extract. The antimicrobial activities of the n-Hexane dragon’s blood resin extract was determined using well diffusion method and the results showed that the extract at concentration of 15% exhibited antimicrobial activities against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Candida albicans 10231 with the diameter inhibition of 13.20 mm; 21.3 mm; and 13.0 mm respectively. The phytochemicals screening showed that the extract contains secondary metabolites in the form of flavonoids. The GC-MS analysis showed that n-Hexane dragon’s blood resin extract contains 48 chemicals compounds, and the compound at RT 26 was indicated a Drachorhodin compound (C17H 18O3) with the mass ration of m/z was 270 g/mol. Overall, the n-Hexane dragon’s blood resin extract be a good choice for antimicrobial agent against bacteria and fungi.
PENERAPAN BIMBINGAN INDIVIDUAL SEBAGAI UPAYA MENINGKATKAN KEMAMPUAN GURU DALAM MENYUSUN SOAL-SOAL HOTS PADA SDN 20 PAYAK ITAM
Authors: Mat Nasir
Published: July 2023

Berdasarkan hasil pengamatan di lapangan terhadap instrumen-instrumen penilaian pencapaian kompetensi, yakni butir-butir soal di sekolah binaan saat melaksanakan pengawasan akademik, ditemukan bahwa  penyusunan tes dan pengembangan butir soal masih banyak yang tidak valid dan reliabel. Dalam mengadakan ulangan harian, ulangan tengah semester, dan ulangan semester, guru hanya menyalin soal-soal dari LKS (lembar kerja siswa) dan atau menyalin dari buku-buku lainnya tanpa memperhatikan apakah soal-soal sesuai dengan indikator-indikator dan kompetensi dasar yang telah ditentukan atau tidak. Mereka menyusun tes dan mengembangkan butir soal terkesan asal-asalan tidak sesuai dengan indikator-indikator dan kompetensi dasar yang telah ditentukan. Peneliti tertarik untuk melakukan penelitian yang berjudul “Meningkatkan Kemampuan Guru Dalam Menyusun Soal-Soal HOTS melalui Bimbingan Individual Pada SDN 20 Payak Itam Tahun Pelajaran 2021/2022”. Metode penelitian ini menggunakan pendekatan kualitatif. Model penelitian ini adalah penelitian tindakan. Hasil penelitian menunjukkan bahwa pada siklus 1 hasil telaah untuk penyusunan dan pengembagan soal-soal HOTS dari 8 orang guru diperoleh nilai rata-rata 85. Dari hasil kuesioner tentang sikap para guru terhadap bimbingan individual 72,84% setuju dan yang masih ragu 27,16%. Ini menunjukkan sikap positif bagi guru terhadap bimbingan individual. Pada siklus 2 hasil telaah untuk penyusunan dan pengembangan soal-soal HOTS diperoleh nilai rata-rata 94. Prosentase kuesioner sikap positif guru pada pra siklus diperoleh 25,16% setuju terhadap model pembimbingan melalui bimbingan individual. Hal ini berarti bahwa guru kurang atau tidak menunjukkan respon positif terhadap bimbingan individual. Mereka menganggap bahwa menyusun butir soal tidak perlu terperinci. Namun setelah tindakan siklus I dan II melalui bimbingan individual respon positif mereka meningkat menjadi 72,84%. Setelah diberikan penguatan pada siklus II, meningkat menjadi 87,65 %.
Targeted recombination of homologous chromosomes using CRISPR‐Cas9
Authors: Son Wonseok , Chung Ki Wha
Published: July 2023

CRISPR mutagenesis is an efficient way to disrupt specific target genes in many model organisms. We previously devised a targeted CRISPR recombination method to generate intragenic recombinants of alleles in Drosophila. Here, we assessed the applicability of CRISPR targeting‐induced recombination to different genetic loci. We compared the ectopic recombination rates in the male germline by CRISPR targeting at two neighboring genetic loci within the genomic region that consists of the repressed chromatin domain of the Lobe gene, and the transcriptionally active domain of PRAS40. Targeting around the transcription initiation of PRAS40 resulted in higher recombination rates of homologous chromosomes than targeting at the Lobe intron. Based on the efficient homologous recombination by CRISPR targeting observed around transcriptionally active loci, we further investigated targeted recombination between P‐elements that are inserted at different genomic locations. Male recombination by CRISPR targeting of P‐elements located proximally and distally to the ebony gene produced recombinants deficient for the intervening region of ebony transcription. Taken together, we suggest that targeted homologous recombination by CRISPR targeting may have specific genetic applications, such as generation of allelic combinations or chromosomal variations.
Prediction of Psoriatic Arthritis in Patients With Psoriasis Using DNA Methylation Profiles
Authors: Cruz‐Correa Omar F. , Pollock Remy A. , Machhar Rohan , Gladman Dafna D.
Published: July 2023

Objective

Psoriatic arthritis (PsA) is an immune‐mediated inflammatory arthritis, associated with psoriasis, that significantly increases morbidity and mortality risk. We currently lack the means of predicting which patients with psoriasis will develop PsA, and a large number of patients remain undiagnosed. Regulation of gene expression through DNA methylation can potentially trigger and maintain PsA pathophysiological processes. We aimed to identify DNA methylation markers that can predict which patients with psoriasis will develop PsA prior to the onset of musculoskeletal symptoms.

Methods

Genome‐wide DNA methylation was assessed in blood samples from patients with psoriasis who went on to develop arthritis (converters) and patients with psoriasis who did not (biologic naive, matched for age, sex, psoriasis duration, and duration of follow‐up). Methylation differences between converters and nonconverters were identified by a multivariate linear regression model including clinical covariates (age, sex, body mass index, smoking). Predictive performance of methylation markers was assessed by developing support vector machine classification models with and without the addition of clinical variables.

Results

We identified a set of 36 highly relevant methylation markers (false discovery rate: adjusted P < 0.05 and a minimum change in methylation of 0.05) across 15 genes and several intergenic regions. A classification model relying on these markers identified converters and nonconverters with an area under the receiver operating characteristic curve of 0.9644.

Conclusion

This study shows that DNA methylation patterns at an early stage of psoriatic disease can distinguish between patients who will develop PsA from those who will not during the same follow‐up.

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Long‐term seedling and small sapling census data from the Barro Colorado Island 50 ha Forest Dynamics Plot, Panama
Authors: Comita Liza S. , Aguilar Salomón , Hubbell Stephen P. , Pérez Rolando
Published: July 2023

Tropical forests are well known for their high woody plant diversity. Processes occurring at early life stages are thought to play a critical role in maintaining this high diversity and shaping the composition of tropical tree communities. To evaluate hypothesized mechanisms promoting tropical tree species coexistence and influencing composition, we initiated a census of woody seedlings and small saplings in the permanent 50 ha Forest Dynamics Plot (FDP) on Barro Colorado Island (BCI), Panama. Situated in old‐growth, lowland tropical moist forest, the BCI FDP was originally established in 1980 to monitor trees and shrubs ≥1 cm diameter at 1.3 m above ground (dbh) at ca. 5‐year intervals. However, critical data on the dynamics occurring at earlier life stages were initially lacking. Therefore, in 2001 we established a 1‐m2 seedling plot in the center of every 5 × 5 m section of the BCI FDP. All freestanding woody individuals ≥20 cm tall and <1 cm dbh (hereafter referred to as seedlings) were tagged, mapped, measured, and identified to species in 19,313 1‐m2 seedling plots. Because seedling dynamics are rapid, we censused these seedling plots every 1–2 years. Here, we present data from the 14 censuses of these seedling plots conducted between the initial census in 2001 to the most recent census, in 2018. This data set includes nearly 1 M observations of ~185,000 individuals of >400 tree, shrub, and liana species. These data will permit spatially‐explicit analyses of seedling distributions, recruitment, growth, and survival for hundreds of woody plant species. In addition, the data presented here can be linked to openly‐available, long‐term data on the dynamics of trees and shrubs ≥1 cm dbh in the BCI FDP, as well as existing data sets from the site on climate, canopy structure, phylogenetic relatedness, functional traits, soil nutrients, and topography. This data set can be freely used for non‐commercial purposes; we request that users of these data cite this data paper in all publications resulting from the use of this data set.
Nutritional composition and consumer acceptance of tomato paste fortified with palm weevil larvae (Rhynchophorus phoenicis Fabricius) in the Ashanti region, Ghana
Authors: Chamoun Loloah , Karboune Salwa , Lutterodt Herman E. , Melgar‐Quinonez Hugo
Published: July 2023

Edible insects, such as palm weevil larvae, have been promoted as an alternative source of nutrients in developing countries for their nutritional benefits, cost‐effective rearing, and yearly availability. Unfortunately, consumer acceptance remains a barrier to their utilization. A supplemental palm weevil larvae and tomato paste were developed as part of efforts to understand whether incorporating edible insects into staple foods could help overcome this barrier. Palm weevil larvae flour and tomato paste were mixed in three formulations that had 8, 15, and 30% of palm weevil larvae flour. Samples were subjected to proximate and mineral content analyses and sensory evaluation. Among the blends, tomato paste containing 30% palm weevil larvae had the highest protein, fat, and total solids content as compared to unfortified tomato paste. Iron and zinc levels also increased with increasing levels of palm weevil larvae flour. Carbohydrate and crude fiber concentrations of the samples, however, decreased with increasing fortification levels. The overall acceptance and willingness to purchase fortified tomato paste as determined by sensory evaluation was high for all samples and increased with increasing knowledge about palm weevil larvae's nutritional benefits. Overall acceptance and willingness to purchase fortified tomato paste were significantly dependent on the samples' color and consumers' overall liking of the products. Tomato paste fortified with palm weevil larvae can provide a complementary source of iron for Ghanaians.
Saline‐aided ultrasound‐guided transoral biopsy of retropharyngeal nodes in head and neck cancer: A feasibility study of five patients
Authors: Ghedia Reshma , Hariri Ahmad , Lee Ying Ki , Dragan Alina , Paleri Vinidh , Ap Dafydd Derfel
Published: July 2023

Background

The purpose of this study was to determine the feasibility of the novel technique of intra‐cavitary saline‐aided ultrasound (US) guided transoral biopsy or excision of retropharyngeal nodes.

Methods

We followed the IDEAL 2a framework to develop this technique. Procedures were performed between July 2020 and July 2022 at a tertiary head and neck center.

Results

Five patients in total underwent an ultrasound‐guided biopsy of a retropharyngeal node. They underwent seven procedures between them: three transoral robotic surgery (TORS) procedures, three fine needle aspirations (FNA) and/or core biopsy procedures, and one US assessment under general anesthetic. The six patients with histology taken (three TORS and three FNA/core biopsies) all had diagnostically adequate samples enabling appropriate treatment planning. There were no significant complications from the procedure.

Conclusion

Saline‐aided US‐guided biopsy of a retropharyngeal node is a safe and useful tool enabling accurate tissue sampling and tumor excision and ongoing appropriate treatment planning.
Source, pattern and flux of dissolved carbon in an alpine headwater catchment on the eastern Tibetan Plateau
Authors: Liu Dong , Wang Tao , Liu Xinyu , Ao Jing , Tang Haiping , Chang Ruiying
Published: July 2023

Dissolved carbon (DC) transported from headwater streams on the eastern Tibetan Plateau is a crucial component of the carbon cycles in the regional river. However, the spatiotemporal variability and sources of DC in these remote headwater streams remains unclear. An investigation into dissolved organic carbon (DOC) and dissolved inorganic carbon (DIC) was conducted with high temporal resolution from a glacier terminus, a forest catchment, and the catchment outlet located on the eastern flank of Mt. Gongga, Southwest China. The results showed that (1) the mean DOC concentration at the glacier terminus (2.38 ± 0.71 mg L−1) was significantly higher than at the forest catchment (2.13 ± 0.49 mg L−1) and at the catchment outlet (2.17 ± 0.58 mg L−1), while the DIC concentration increased by 21.6% at the forest catchment and by 18.7% at the catchment outlet relative to that in the glacier terminus. (2) Compared to the monsoon season, DOC concentrations in the forest catchment decreased by 24.6% postmonsoon, and the seasonal variation of DOC concentrations was minor either at the glacier terminus or at the catchment outlet; relative to monsoon values, postmonsoon DIC concentrations increased by 14.9% and 28.8% at the forest catchment and catchment outlet, respectively. Precipitation and stream pH were identified as important factors influencing the seasonal variability of DC. (3) Silicate and carbonate weathering contributed 52.9 ± 12% and 44.4 ± 9%, respectively, to DIC generation in the forest catchment according to 13C analysis. This study provides a valuable dataset on the dynamics of DC in a region where data is sparse, which improves our understanding of DC transport in alpine regions. The unexpected spatiotemporal stability of DC suggests that less frequent rates of sampling might be adequate to estimate carbon export.
A Surrogate Model Approach for Studying Performance and Cycle Time in Complex System Development
Authors: Chiesi Stephanie Sharo , Grogan Paul T.
Published: July 2023

This paper presents a surrogate model approach to advance fundamental research on understanding impacts of engineering decision‐making on complex system performance and system development cycle times. The approach is motivated by digital transformation and advancement of the digital engineering strategy by the U.S. Department of Defense as part of acquisition modernization. The digital engineering strategy focuses on five goals as a means to reduce acquisition cycle times and increase capability deployment to the warfighter, but we lack the theory to understand the impact of the digital transformation on engineering processes, decision‐making and the solution performance. The surrogate model approach discussed herein could provide a methodology for studying the impact of digital engineering on solution performance and lifecycle development time on a wide class of design problems with tunable complexity.
Inconsistent and Incomplete Datasheet: The case for systematic use of requirement engineering
Authors: Brisacier‐Porchon Lorraine , Hammami Omar
Published: July 2023

The lifecycle of a system is extended from its early conception to its retirement of service. The lifespan of Unmanned Ground Vehicles (UGVs) can be expected to last over 50 years in the defense market. In this context, the rising complexity of UGV systems imposes engineering steps that would ensure both capabilities of the system and resilience to its future inclusion in a system‐of‐system context. During its operational usage, the UGV is supposed to be maneuvered for specifically designed purposes following user manual datasheet of the components off‐the‐shelf (COTS) that were integrated. This paper exposes the public user datasheet relevance compared to the system engineering requirements that are the artifacts of system design architecture. The use of connecting COTS user manual to system requirements is discussed, all the more if the systems are to be re‐used in a system production line. This article is intended to explore system of system conception methods for future robotized battlefield.
Internalization of extracellular vesicles from Lactobacillus johnsonii N6.2 elicit an RNA sensory response in human pancreatic cell lines
Authors: da Silva Danilo R. , Gonzalez Claudio F. , Lorca Graciela
Published: July 2023

Cells of all domains of life can secrete extracellular vesicles (EV). These secreted vesicles have been indicated as vehicles carrying molecules that facilitate intra‐ and inter‐species interaction. Lactobacillus johnsonii N6.2, a bacterium used in probiotic preparations, has been shown to produce nano‐sized EV. In the present work we used L. johnsonii N6.2 EV, concentrated from exosome‐depleted MRS supernatant, to identify the uptake mechanisms of EV and the impact of the RNA cargo in the EV on the upregulation of the cellular response of βlox5 human pancreatic cells. Using eukaryotic uptake inhibitors, it was found that EV are internalized by the clathrin/dynamin mediated endocytosis pathway. Further co‐localization experiments with the endosome markers RAB5, RAB7 and LAMP1 as well as calcein indicated that EV escape the endosome shortly after RAB7 fusion. Using the expression of the 2′,5′‐oligoadenylate synthetase (OAS) host pathway, previously identified as targeted by L. johnsonii EV, we found that the host cellular response to the EV are dependent on the integrity of the external components of the EV as well as on the RNA cargo. Global transcriptome analysis was performed on EV and the bacterial whole cell. It was found that the RNA transcripts found within the EV largely represent the most abundantly transcribed genes in the bacterial cells such as those associated with protein synthesis and glycolysis. Further analysis showed an enrichment of smaller size transcripts as well as those encoding for membrane bound or extracellular proteins in L. johnsonii’s EV.
The pivotal role of high‐resolution mass spectrometry in the study of grape glycosidic volatile precursors for the selection of grapevines resistant to mildews
Authors: De Rosso Mirko , Panighel Annarita , Migliaro Daniele , Possamai Tyrone , De Marchi Fabiola , Velasco Riccardo , Flamini Riccardo
Published: July 2023

A breeding program to produce new grape varieties tolerant to main vine fungal pathogens (Plasmopara viticola and Erysiphe necator) is carrying out by crossing Vitis vinifera cv. “Glera” with resistant genotypes such as “Solaris,” “Bronner,” and “Kunleany.” Firstly, resistance gene‐based markers analyses allowed the identification of five genotypes, which have inherited the resistance loci against mildews. To select those that also inherited the phenotype as close as possible to ‘Glera’ suitable to be introduced in the Prosecco wine production protocols, the grape glycosidic derivatives were studied by UHPLC/QTOF mass spectrometry. Targeted identification of the metabolites was performed using a database expressly constructed by including the glycosidic volatile precursors previously identified in grape and wine. A total of 77 glycosidic derivatives including many aroma precursors and some variety markers, were identified. Original resistant genotypes had distinct metabolomic profiles and different to ‘Glera’, while the crossings showed varying similarity degrees to V. vinifera parent. Findings demonstrated the Glera × Bronner and Glera × Solaris crossings are more suitable to produce high‐sustainable Prosecco wines. Coupling of glycosidic volatile precursors profiling to multivariate statistical analysis was effective for phenotypic characterization of grapes and to evaluate their enological potential.