bluuebunny/crossref_metadata_2025 huggingface dataset:
Theory of mind deficits in language delayed deaf subjects?
Authors: Begby Endre
Published: November 2023

Recent studies claim to show that language delayed deaf subjects typically display longlingering deficits in Theory of Mind (ToM) development, despite suffering no known deficits in other cognitive domains. These claims are supported by experimental evidence indicating that such subjects fare poorly on False Belief (FB) tasks. This paper turns a critical eye on these claims. In particular, I argue that the reported results raise important questions about the status of FB tasks as evidence, and about how such evidence should be weighted against naturalistic observations of subjects engaged in everyday activities requiring complex social coordination. I conclude that these studies give us no decisive reason to believe that language delayed deaf subjects suffer distinctively and symptomatically in the domain of social cognition. To the contrary, the attribution of significant socio-cognitive impairment is potentially stigmatizing and may not help us understand the unique challenges these subjects face or suggest remedial strategies to aid them in overcoming these challenges.
Proceedings of the symposium Woodworking Tools and Techniques –Past, Present and Future, Stockholm 16-19 September 2022
Authors: Andersson Elise
Published: November 2023

The 3rd Swedish Symposium on Furniture Technology& Design was held in Stockholm the 16th through the19th of September 2022, this time arranged by MalmstensAlumni in collaboration with the Swedish History Museum,Skokloster Castle and LiU Malmstens.
Impact of Infection-Related Immunosuppressant Reduction on Kidney Transplant Outcomes: A Retrospective Study Considering the Temporal Dynamics of Immunosuppressive Requirements
Authors: Yang Bo , Ye Qianqian , Huang Changhao , Ding Xiang
Published: November 2023

Immunosuppressant reduction (ISR) is a common treatment for kidney transplant recipients experiencing infections, but its impacts on kidney transplant outcomes remains unclear. This retrospective single-center study included 300 patients who underwent kidney transplantation between January 2017 and April 2020. The post-transplant timeline was divided into four distinct phases: ≤1 month, 2–6 months, 7–12 months, and >12 months. Patients were categorized based on the presence of clinically relevant infections and whether they received ISR. Significant differences were observed in the spectrum of clinically relevant infections across the post-transplant phases. During the ≤1 month phase, primary infections were associated surgical operation, such as urinary tract infections involving Enterococcus spp. and Candida spp. Cytomegalovirus and BK polyomavirus (BKPyV) infections increased during the 2–6 months and 7–12 months periods. Approximately one-third of patients experienced ISR due to infection, with BKPyV infections being the primary causes. Recipients who experienced their first ISR due to infection between 2–6 months and 7–12 months had worse graft survival comparing with patients without any infections. ISR due to infections between 2 and 6 months was associated with a higher risk of rejection. Tailored ISR strategies should be developed according to temporal dynamics of immunosuppressive intensity to prevent rejection.
Uterine Arteries Resistance in Pregnant Women with Gestational Diabetes Mellitus, Diabetes Mellitus Type 1, Diabetes Mellitus Type 2, and Uncomplicated Pregnancies
Authors: Chatzakis Christos , Eleftheriades Makarios , Demertzidou Eleftheria , Eleftheriades Anna , Koletsos Nikolaos , Lavasidis Lazaros , Zikopoulos Athanasios , Dinas Konstantinos , Sotiriadis Alexandros
Published: November 2023

Background: The examination of the uterine arteries using Doppler in the first trimester of pregnancy serves as a valuable tool for evaluating the uteroplacental circulation. Diabetes mellitus is associated with altered placental implantation and pregnancy-related pathologies, such as preeclampsia. The aim of this study was to compare the uterine arteries’ pulsatility indices (UtA PI) in women with diabetes mellitus type 1 (DM1), diabetes mellitus type 2 (DM2), gestational diabetes mellitus (GDM), and uncomplicated pregnancies. Methods: This was a retrospective case–control trial including pregnant women with DM1, DM2, GDM, and uncomplicated pregnancies, presenting for first-trimester ultrasound screening in two tertiary university hospitals between 2013 and 2023. The first-trimester UtA pulsatility index (PI), expressed in multiples of medians (MoMs), was compared between the four groups. Results: Out of 15,638 pregnant women, 58 women with DM1, 67 women with DM2, 65 women with GDM, and 65 women with uncomplicated pregnancies were included. The mean UtA PI were 1.00 ± 0.26 MoMs, 1.04 ± 0.32 MoMs, 1.02 ± 0.31 MoMs, and 1.08 ± 0.33 MoMs in pregnant women with DM1, DM2, GDM, and uncomplicated pregnancies, respectively (p > 0.05). Conclusions: Potential alterations in the implantation of the placenta in pregnant women with diabetes were not displayed in the first-trimester pulsatility indices of the uterine arteries, as there were no changes between the groups.
Unsuitability of the Oxidation-Reduction Potential Measurement for the Quantification of Fecal Redox Status in Inflammatory Bowel Disease
Authors: Geertsema Sem , Jansen Bernadien H. , van Goor Harry , Dijkstra Gerard , Faber Klaas Nico , Bourgonje Arno R.
Published: November 2023

Oxidative stress is a key pathophysiological process associated with the development and progression of inflammatory bowel disease (IBD). Biomarkers for oxidative stress, however, are scarce, as are diagnostic tools that can interrogate an individual’s gut redox status. This proof-of-concept study aimed to evaluate the potential utility of an oxidation-reduction potential (ORP) measurement probe, to quantify redox status in the feces of both patients with IBD and healthy controls. Previous studies using this ORP measurement probe demonstrated promising data when comparing ORP from severely malnourished individuals with that of healthy controls. To date, ORP analyses have not been performed in the context of IBD. We hypothesized that measuring the ORP of fecal water in patients with IBD might have diagnostic value. The current study, however, did not show significant differences in ORP measurement values between patients with IBD (median [IQR] 46.5 [33.0–61.2] mV) and healthy controls (25 [8.0–52.0] mV; p = 0.221). Additionally, ORP measurements were highly unstable and rapidly fluctuated throughout time, with ORP values varying from +24 to +303 mV. Due to potential biological processes and limitations of the measuring equipment, this study was unable to reliably measure ORP. As a result, our findings indicate that ORP quantification may not be a suitable method for assessing fecal redox status and, therefore, does not currently support further exploration as a diagnostic or monitoring tool.
Broken Arrows: Hardy–Unruh Chains and Quantum Contextuality
Authors: Janas Michael , Janssen Michel
Published: November 2023

Hardy and Unruh constructed a family of non-maximally entangled states of pairs of particles giving rise to correlations that cannot be accounted for with a local hidden-variable theory. Rather than pointing to violations of some Bell inequality, however, they pointed to apparent clashes with the basic rules of logic. Specifically, they constructed these states and the associated measurement settings in such a way that the outcomes satisfy some conditionals but not an additional one entailed by them. Quantum mechanics avoids the broken ‘if …then …’ arrows in such Hardy–Unruh chains, as we call them, because it cannot simultaneously assign truth values to all conditionals involved. Measurements to determine the truth value of some preclude measurements to determine the truth value of others. Hardy–Unruh chains thus nicely illustrate quantum contextuality: which variables do and do not obtain definite values depends on what measurements we decide to perform. Using a framework inspired by Bub and Pitowsky and developed in our book Understanding Quantum Raffles (co-authored with Michael E. Cuffaro), we construct and analyze Hardy–Unruh chains in terms of fictitious bananas mimicking the behavior of spin-12 particles.
Research Performance: A View of Research Self-Efficacy, Interest, and Gender
Authors: Sasson Irit , Miedijensky Shirley
Published: November 2023

There is great interest in promoting research in academic institutions and a need to understand the various factors influencing it. The main goals of this study are to investigate the factors that predict academic research outcomes and how gender and research authority (RA) support programs affect the relationship between research self-efficacy and research interest. The participants included 143 faculty members who completed a questionnaire, 19 of whom were interviewed. The results indicate that the faculty members’ research interests and the RA’s support significantly predicted academic research outcomes. A positive and significant correlation was found between research self-efficacy and research interest. Gender and RA support were found to significantly moderate this relationship. Research self-efficacy had almost no effect on research interest among female faculty members and among faculty members who had received support from the research authority. In contrast, among male faculty members and among those who did not receive support from the research authority, the higher the research self-efficacy, the higher the research interest. An analysis of faculty members’ perceptions points to four factors that can advance research outcomes: support from the RA, mentoring, collaboration among researchers, and allotting time for research. Understanding the moderating role of gender is important to reveal the underlying mechanism of a gender gap in research interest and consequently in academic performance, considering the increased recognition that universities worldwide are male dominated and that women are underrepresented in senior positions in academia.
Temperature and Dissolved Oxygen Lead to Behavior and Respiration Changes in Juvenile Largemouth Bass (Micropterus salmoides) during Transport
Authors: Gui Fukun , Sun Haofeng , Qu Xiaoyu , Niu Shuai , Zhang Guangyang , Feng Dejun
Published: November 2023

The study aimed to investigate the effects of temperature and dissolved oxygen on juvenile largemouth bass during transportation. The experiment involved four temperature groups: 20, 15, 10, and 5 °C. We analyzed the effects of acute and uniform cooling on fish behavior to determine the optimal approach for cooling. Then, we simulated transport under different temperature conditions while measuring the dissolved oxygen level and metabolic rate until all the fish died. The results showed that acute cooling significantly influenced the tail-beat frequency of fish compared with uniform cooling, while abnormal behaviors such as increased swimming, attempted jumping out of the water, and loss of balance were observed. As the transport temperature reduced, the oxygen consumption rate of fish significantly changed at 10 °C, being 2.6 times lower than at 15 °C, with values of 0.10 ± 0.02 and 0.47 ± 0.07 mg·g−1·h−1, respectively. The critical oxygen threshold (Pcrit) of fish were 1.90 ± 0.12, 1.61 ± 0.04, 1.15 ± 0.09, and 1.12 ± 0.25 mg·L−1 at 5, 10, 15, and 20 °C. In addition, below Pcrit, hypoxia-led behavior changes and oxygen consumption rate reduction were observed at every transport temperature. The findings suggest that the optimal low temperature can reduce metabolism and improve the hypoxia tolerance of juvenile largemouth bass. We recommend transporting largemouth bass at an optimal low temperature (15 °C), monitoring fish behavior, and maintaining oxygen levels above Pcrit during transport to prevent stress.
Effects of Replacing Fish Meal with Stickwater Hydrolysate and Meal on the Growth, Serum Biochemical Indexes, and Muscle Quality of Yellow Catfish (Tachysurus fulvidraco)
Authors: Zheng Shuang , Shi Yong , Zhang Junzhi , Dai Jihong , Hu Yi , Zhong Lei
Published: November 2023

An eight-week feeding experiment was conducted to evaluate the effects of replacing fish meal with stickwater hydrolysate (SWH) or stickwater hydrolysate meal (SWM) on the growth, serum biochemical parameters, intestinal digestive enzyme activity, and muscle quality of yellow catfish (Tachysurus fulvidraco). The control diet (CON) contained 30% fish meal and the remaining five diets were substituted for fish meal with 2.5% (SWM2.5), 5% (SWM5) SWM, and 5% (SWH5), 10% (SWH10), and 15% (SWH15) SWH, respectively. The results showed that there were no significant differences in weight gain rate, feed conversion rate, survival rate, hepatosomatic index, and viscerosomatic index among the groups. The substitution of fish meal with SWH significantly augmented the serum triglyceride and total cholesterol levels, whereas urea nitrogen content exhibited a reduction proportional to the replacement ratio. The incorporation of SWH led to a notable rise in glutamate-pyruvate transaminase activity, albeit with a gradual decline as the substitution ratio escalated. Relative to the CON group, the SWH5 group displayed a significant reduction in serum superoxide dismutase activity and a significant elevation in serum catalase activity. The substitution of fish meal with SWM yielded noticeable increments in the activities of complement 3, immunoglobulin M, and alkaline phosphatase. Neither SWH nor SWM exerted a substantial influence on intestinal amylase activity. Regarding muscle characteristics, neither SWH nor SWM showed a marked effect on hardness and springiness; however, adhesiveness, cohesiveness, gumminess, and chewiness properties exhibited enhancement as the proportion of fish meal replacement increased. In conclusion, within this experimental context, substituting fish meal with SWH and SWM did not adversely impact the growth and meat quality of yellow catfish. Specifically, replacing 15% fish meal with stickwater hydrolysate and 5% fish meal with stickwater hydrolysate meal contributed to an enhanced immune capacity in yellow catfish to a certain extent.
Leveraging Technology to Diagnose Alzheimer’s Disease: A Systematic Review and Meta-Analysis
Authors: Kruse Clemens Scott , Mileski Michael E. , Wilkinson Reagan , Hock Britney , Samson Roger , Castillo Taylor
Published: November 2023

Background: About 50 million people worldwide suffered from dementia in 2018—two-thirds of those with Alzheimer’s disease (AD). By 2050, this number is expected to rise to 152 million—which is slightly larger than the country of Russia. About 90% of these people are over the age of 65, but early-onset dementia can occur at younger ages. Early detection is imperative to expedient treatment, which can improve outcomes over the span of diagnosis. Objectives: To conduct a meta-analysis of similar studies along with a systematic literature review to hasten the development of clinical practice guidelines to assist clinicians in the diagnosis of AD. We analyzed data points in each article published over the last 10 years to meet this objective: cost, efficiency, accuracy, acceptability (by physician and patient), patient satisfaction, and barriers to adoption. Methods: Four research databases were queried (PubMed, CINAHL Ultimate, Web of Science, and ScienceDirect). The review was conducted in accordance with a published protocol, the Kruse Protocol, and reported in accordance with PRISMA (2020). Results: Ten interventions were identified to help diagnose AD among older patients, and some involved a combination of methods (such as MRI and PET). The average sample size was 320.32 (SD = 437.51). These 10 interventions were identified as accurate, non-invasive, non-stressful, inexpensive, convenient, and rapid. Only one intervention was identified as statistically ineffective, and this same intervention was used effectively in other studies. The barriers identified were cost, training, expense of travel, and required physical presence of patient. The weighted average sensitivity was 85.16%, specificity was 88.53, and the weighted average effect size was 0.7339 (medium). Conclusion: Innovation can accurately diagnose AD, but not all methods are successful. Providers must ensure they have the proper training and familiarity with these interventions to ensure accuracy in diagnosis. While the physical presence of the patient is often required, many interventions are non-invasive, non-stressful, and relatively inexpensive.
Calibration of Land-Use-Dependent Evaporation Parameters in Distributed Hydrological Models Using MODIS Evaporation Time Series Data
Authors: Casper Markus C. , Salm Zoé , Gronz Oliver , Hutengs Christopher , Mohajerani Hadis , Vohland Michael
Published: November 2023

The land-use-specific calibration of evapotranspiration parameters in hydrologic modeling is challenging due to the lack of appropriate reference data. We present a MODIS-based calibration approach of vegetation-related evaporation parameters for two mesoscale catchments in western Germany with the physically based distributed hydrological model WaSiM-ETH. Time series of land-use-specific actual evapotranspiration (ETa) patterns were generated from MOD16A2 evapotranspiration and CORINE land-cover data from homogeneous image pixels for the major land-cover types in the region. Manual calibration was then carried out for 1D single-cell models, each representing a specific land-use type based on aggregated 11-year mean ETa values using SKout and PBIAS as objective functions (SKout > 0.8, |PBIAS| < 5%). The spatio-temporal evaluation on the catchment scale was conducted by comparing the simulated ETa pattern to six daily ETa grids derived from LANDSAT data. The results show a clear overall improvement in the SPAEF (spatial efficiency metric) for most land-use types, with some deficiencies for two scenes in spring and late summer due to phenological variation and a particularly dry hydrological system state, respectively. The presented method demonstrates a significant improvement in the simulation of ETa regarding both time and spatial scale.
Assessment of Potential Potable Water Reserves in Islamabad, Pakistan Using Vertical Electrical Sounding Technique
Authors: Rashid Mehboob ur , Kamran Muhammad , Zeb Muhammad Jawad , Islam Ihtisham , Janjuhah Hammad Tariq , Kontakiotis George
Published: November 2023

This study aimed to investigate the potential reserves of potable water in Islamabad, Pakistan, considering the alarming depletion of water resources. A detailed vertical electrical sounding (VES) survey was conducted in two main localities: Bara Kahu (Area 1) and Aabpara to G-13 (Area 2), based on accessibility, time, and budget constraints. A total of 23 VES measurements were performed, with 13 in Area 1 and 10 in Area 2, reaching a maximum depth of 500 m. Geologs and pseudosections were generated to assess lithological variations, aquifer conditions, and resistivity trends with depth. Statistical distribution of resistivity (SDR), hydraulic parameters, true resistivity, macroanisotropy, aquifer depth and thickness, and linear regression (R2) curves were calculated for both areas, providing insights into the aquifer conditions. The results revealed that the study areas predominantly consisted of sandy lithology as the aquifer horizon, encompassing sandstone, sandy clay, and clayey sand formations. Area 2 exhibited a higher presence of clayey horizons, and aquifers were generally deeper compared to Area 1. The aquifer thickness ranged from 10 m to 200 m, with shallow depths ranging from 10 m to 60 m and deeper aquifers exceeding 200 m. Aquifers in Area 1 were mostly semi-confined, while those in Area 2 were predominantly unconfined and susceptible to recharge and potential contamination. The northwest–southeast side of Area 1 exhibited the highest probability for ground resource estimation, while in Area 2, the northeast–southwest side displayed a dominant probability. The study identified a probable shear zone in Area 2, indicating lithological differences between the northeast and southwest sides with a reverse sequence. Based on the findings, it is recommended that the shallow aquifers in Area 1 be considered the best potential reservoir for water supply. In contrast, deeper drilling is advised in Area 2 to ensure a long-lasting, high-quality water supply. These results provide valuable information for water resource management and facilitate sustainable water supply planning and decision making in Islamabad, Pakistan.
Cystic Fibrosis Cases Missed by Newborn Bloodspot Screening—Towards a Consistent Definition and Data Acquisition
Authors: Munck Anne , Southern Kevin W. , Murphy Jared , de Winter-de Groot Karin M. , Gartner Silvia , Karadag Bülent , Kashirskaya Nataliya , Linnane Barry , Proesmans Marijke , Sands Dorota , Sommerburg Olaf , Castellani Carlo , Barben Jürg
Published: November 2023

Repeated European surveys of newborn bloodspot screening (NBS) have shown varied strategies for collecting missed cases, and information on data collection differs among countries/regions, hampering data comparison. The ECFS Neonatal Screening Working Group defined missed cases by NBS as either false negatives, protocol-related, concerning analytical issues, or non-protocol-related, concerning pre- and post-analytical issues. A questionnaire has been designed and sent to all key workers identified in each NBS programme to assess the feasibility of collecting data on missed cases, the stage of the NBS programme when the system failed, and individual patient data on each missed case.
Probing the Reactivity of [4Fe-4S] Fumarate and Nitrate Reduction (FNR) Regulator with O2 and NO: Increased O2 Resistance and Relative Specificity for NO of the [4Fe-4S] L28H FNR Cluster
Authors: Crack Jason C. , Amara Patricia , de Rosny Eve , Darnault Claudine , Stapleton Melanie R. , Green Jeffrey , Volbeda Anne , Fontecilla-Camps Juan C. , Le Brun Nick E.
Published: November 2023

The Escherichia coli fumarate and nitrate reduction (FNR) regulator acts as the cell’s master switch for the transition between anaerobic and aerobic respiration, controlling the expression of >300 genes in response to O2 availability. Oxygen is perceived through a reaction with FNR’s [4Fe-4S] cluster cofactor. In addition to its primary O2 signal, the FNR [4Fe-4S] cluster also reacts with nitric oxide (NO). In response to physiological concentrations of NO, FNR de-represses the transcription of hmp, which encodes a principal NO-detoxifying enzyme, and fails to activate the expression of the nitrate reductase (nar) operon, a significant source of endogenous cellular NO. Here, we show that the L28H variant of FNR, which is much less reactive towards O2 than wild-type FNR, remains highly reactive towards NO. A high resolution structure and molecular dynamics (MD) simulations of the closely related L28H-FNR from Aliivibrio fischeri revealed decreased conformational flexibility of the Cys20-Cys29 cluster-binding loop that is suggested to inhibit outer-sphere O2 reactivity, but only partially impair inner-sphere NO reactivity. Our data provide new insights into the mechanistic basis for how iron–sulfur cluster regulators can distinguish between O2 and NO.
Between Domestication and Foreignization: A Study of How an Italian Film Remake Got Lost in Translation in the Arab World
Authors: Saad Charleine
Published: November 2023

Film remakes represent a form of cinematic translation that reconstructs various elements of the original text. This article relies on the translation strategies of domestication and foreignization to analyze “Āṣḥāb Wālā Āʿāz”, the Arabic remake of the Italian film “Perfetti Sconosciuti” or “Perfect Strangers”. This study shows that the Arabic remake, which sparked controversy across the Middle East, replicates many of the syntactic elements of the original film, such as the narrative and the plot structure, as well as cinematographic and paralinguistic elements. Still, it attempts to adopt a transformative approach in order to generate a cultural production. The result shows that the use of domestication in film remakes alters the rhetorical effect of the original version and that, although foreignization may promote an audience’s interest in foreign cultures, it may contribute to the reproduction of otherness due to the dissatisfaction of the targeted audiences.
«¡La de + N + que…!» The Feminine Definite Article in Spanish Exclamative Clauses
Authors: Arias Juan José
Published: November 2023

The present study explores the exclamative use of the feminine definite article la in structures such as ‘¡La de chicos que besé en la fiesta!’ (How many guys I kissed at the party!). First, a morphosyntactic description of the pattern is offered so as to show that the data under analysis are pseudopartitive constructions which display all the characteristics of primary and partial exclamatives. Building on research on nominal exclamatives, we conclude that these examples are not CPs but indefinite DPs with an exclamative flavor which contain a semi-relative clause introduced by que. Within the framework of Distributed Morphology, we schematize a set of syntactic structures which capture the ‘chimeric’ and hybrid nature of the data, these being halfway between DPs and exclamative clauses. In order to do so, it will be necessary to split the DP into smaller projections (FocP, FinP), since la must move to Spec-FocP to be interpreted as an exclamative operator.
Properties of Macadam Stabilized with Cement and Asphalt Emulsion
Authors: Sun Jian , Huang Yong , He Yulin , Andrii Bieliatynskyi , Liu Wen
Published: November 2023

The cracking of cement-stabilized macadam (CSM) reflects to the asphalt layer, which is one of the reasons for the failure of pavement performance and structure. Adding asphalt emulsion to CSM can effectively prevent the formation of cracks. The primary purpose of this article is to reveal the effect of asphalt emulsions on the performance of CSM by adding different contents of asphalt emulsion. For this purpose, tests of unconfined compressive strength (UCS), flexural tensile strength (FTS), elastic modulus, and frost resistance were performed on CSM with gradations of CSM-5 and CSM-10 (the maximum particle sizes of the macadam in the gradation composition are 5 mm and 10 mm), respectively. The test results showed that the UCS of CSM decreased with the increment of asphalt emulsion content. The FTS and elastic modulus of CSM increased with the content of asphalt emulsion. Based on the FTS test results, the frost resistance coefficient Km1, defined according to the CSM splitting strength prior to and subsequent to freeze–thaw, was used to evaluate the frost resistance. The test results showed that the frost resistance of CSM improved with the increase in asphalt emulsion content for the same cement content. In conclusion, adding asphalt emulsion to CSM has positive effects on the FTS, elastic modulus, and frost resistance. Therefore, for the purpose of maintaining the UCS value of CSM, the content of cement should be considered at the same time as the controlling of the content of asphalt emulsion.
Biological Characterization and Whole-Genome Analysis of Bacillus subtilis MG-1 Isolated from Mink Fecal Samples
Authors: Ren Jianwei , Yu Detao , Li Nianfeng , Liu Shuo , Xu Hang , Li Jiyuan , He Fang , Zou Ling , Cao Zhi , Wen Jianxin
Published: November 2023

Bacillus subtilis is an important part of the gut microbiota and a commonly used probiotic. In the present study, to assess the biological characteristics and probiotic properties of B. subtilis derived from mink, we isolated B. subtilis MG-1 isolate from mink fecal samples, characterized its biological characteristics, optimized the hydrolysis of casein by its crude extract, and comprehensively analyzed its potential as a probiotic in combination with whole-genome sequencing. Biological characteristics indicate that, under low-pH conditions (pH 2), B. subtilis MG-1 can still maintain a survival rate of 64.75%; under the conditions of intestinal fluid, gastric acid, and a temperature of 70 °C, the survival rate was increased by 3, 1.15 and 1.17 times compared with the control group, respectively. This shows that it can tolerate severe environments. The results of hydrolyzed casein in vitro showed that the crude bacterial extract of isolate MG-1 exhibited casein hydrolyzing activity (21.56 U/mL); the enzyme activity increased to 32.04 U/mL under optimized reaction conditions. The complete genome sequencing of B. subtilis MG-1 was performed using the PacBio third-generation sequencing platform. Gene annotation analysis results revealed that B. subtilis MG-1 was enriched in several Kyoto Encyclopedia of Genes and Genomes (KEGG) metabolic pathways, and most genes were related to Brite hierarchy pathways (1485–35.31%) and metabolism pathways (1395–33.17%). The egg-NOG annotation revealed that most genes were related to energy production and conversion (185–4.10%), amino acid transport and metabolism (288–6.38%), carbohydrate transport and metabolism (269–5.96%), transcription (294–6.52%), and cell wall/membrane/envelope biogenesis (231–5.12%). Gene Ontology (GO) annotation elucidated that most genes were related to biological processes (8230–45.62%), cellular processes (3582–19.86%), and molecular processes (6228–34.52%). Moreover, the genome of B. subtilis MG-1 was predicted to possess 77 transporter-related genes. This study demonstrates that B. subtilis MG-1 has potential for use as a probiotic, and further studies should be performed to develop it as a probiotic additive in animal feed to promote animal health.
Immunoinformatics and Evaluation of Peptide Vaccines Derived from Global Hepatitis B Viral HBx and HBc Proteins Critical for Covalently Closed Circular DNA Integrity
Authors: Saeed Umar , Piracha Zahra Zahid , Alrokayan Salman , Hussain Tajamul , Almajhdi Fahad N. , Waheed Yasir
Published: November 2023

The Hepatitis B virus (HBV) HBx and HBc proteins play a crucial role in associating with covalently closed circular DNA (cccDNA), the primary factor contributing to intrahepatic viral persistence and a major obstacle in achieving a cure for HBV. The cccDNA serves as a reservoir for viral persistence. Targeting the viral HBc and HBx proteins’ interaction with cccDNA could potentially limit HBV replication. In this study, we present epitopes identified from global consensus sequences of HBx and HBc proteins that have the potential to serve as targets for the development of effective vaccine candidates. Furthermore, conserved residues identified through this analysis can be utilized in designing novel, site-specific anti-HBV agents capable of targeting all major genotypes of HBV. Our approach involved designing global consensus sequences for HBx and HBc proteins, enabling the analysis of variable regions and highly conserved motifs. These identified motifs and regions offer potent sites for the development of peptide vaccines, the design of site-specific RNA interference, and the creation of anti-HBV inhibitors. The epitopes derived from global consensus sequences of HBx and HBc proteins emerge as promising targets for the development of effective vaccine candidates. Additionally, the conserved residues identified provide valuable insights for the development of innovative, site-specific anti-HBV agents capable of targeting all major genotypes of HBV from A to J.
Marine Bacterial Community Structures of Selected Coastal Seawater and Sediment Sites in Qatar
Authors: El-Malah Shimaa S. , Rasool Kashif , Jabbar Khadeeja Abdul , Sohail Muhammad Umar , Baalousha Husam Musa , Mahmoud Khaled A.
Published: November 2023

Severe environmental conditions can have a diverse impact on marine microorganisms, including bacteria. This can have an inevitable impact on the biofouling of membrane-based desalination plants. In this work, we have utilized indicator bacteria such as total coliform, fecal coliform, and Pseudomonas aeruginosa, as well as 16S rRNA sequencing, to investigate the impact of environmental conditions and spatial variations on the diversity of bacterial communities in the coastal waters and sediments from selected sites in Qatar. The concentration levels of indicator bacteria were affected by increasing temperatures and pH, and by decreasing salinity of seawater samples. Diversity indices and the molecular phylogeny demonstrated that Proteobacteria, Bacteroidetes, and Cyanobacteria were the dominant phyla in all locations. The most abundant operational taxonomic units (OTUs) at the family level were from Flavobacteriaceae (27.07%, 4.31%) and Rhodobacteraceae (22.51%, 9.86%) in seawater and sediment, respectively. Alphaproteobacteria (33.87%, 16.82%), Flavobacteria (30.68%, 5.84%), and Gammaproteobacteria (20.35%, 12.45%) were abundant at the species level in both seawater and sediment, while Clostridia (13.72%) was abundant in sediment only. The results suggest that sediment can act as a reservoir for indicator bacteria, with higher diversity and lower abundance compared to seawater.
Interactions between Cyanobacteria and Methane Processing Microbes Mitigate Methane Emissions from Rice Soils
Authors: Pérez Germán , Krause Sascha M. B. , Bodelier Paul L. E. , Meima-Franke Marion , Pitombo Leonardo , Irisarri Pilar
Published: November 2023

Cyanobacteria play a relevant role in rice soils due to their contribution to soil fertility through nitrogen (N2) fixation and as a promising strategy to mitigate methane (CH4) emissions from these systems. However, information is still limited regarding the mechanisms of cyanobacterial modulation of CH4 cycling in rice soils. Here, we focused on the response of methane cycling microbial communities to inoculation with cyanobacteria in rice soils. We performed a microcosm study comprising rice soil inoculated with either of two cyanobacterial isolates (Calothrix sp. and Nostoc sp.) obtained from a rice paddy. Our results demonstrate that cyanobacterial inoculation reduced CH4 emissions by 20 times. Yet, the effect on CH4 cycling microbes differed for the cyanobacterial strains. Type Ia methanotrophs were stimulated by Calothrix sp. in the surface layer, while Nostoc sp. had the opposite effect. The overall pmoA transcripts of Type Ib methanotrophs were stimulated by Nostoc. Methanogens were not affected in the surface layer, while their abundance was reduced in the sub surface layer by the presence of Nostoc sp. Our results indicate that mitigation of methane emission from rice soils based on cyanobacterial inoculants depends on the proper pairing of cyanobacteria–methanotrophs and their respective traits.
Extracutaneous Melanotic Melanoma with Nervous System Involvement in a Buffalo (Bubalus bubalis)
Authors: Barbosa José Diomedes , Oliveira Mariana Correia , Oliveira Carlos Magno Chaves , Bomjardim Henrique dos Anjos , Ferreira Tatiane Teles Albernaz , Duarte Marcos Dutra , da Silveira José Alcides Sarmento , Silveira Natália da Silva e Silva , Barbosa Camila Cordeiro , da Silva Aluízio Otávio Almeida , Armién Anibal , Brito Marilene de Farias
Published: November 2023

Melanomas are tumors arising from externally uncontrolled melanocytes that produce varying amounts of melanin. In this study, we report a case of melanoma with neurological impairment without evidence of cutaneous neoplastic lesions in an adult buffalo in the state of Pará, Brazil. Clinically, the buffalo exhibited apathy, decreased mandibular tone, and occasionally an open mouth with motor incoordination, and eventually succumbed to the condition. Necropsy revealed multifocal tumor masses in the brain, pituitary gland, trigeminal ganglion, and spinal cord. The neoplastic cells showed strong positive signals for vimentin, Melan-A, PNL-2, and SOX10. The diagnosis was made via necropsy, histopathology, and positive immunostaining for Melan-A and PNL-2, which are specific markers for melanocyte identification.
Perancangan Sistem Informasi Persediaan Dan Penjualan Pada CV. Super Makmur Sentosa
Authors: William Pranata Kusuma  , Jasmir  , Aryani Lies
Published: November 2023

Super Makmur Sentosa merupakan suatu usaha yang bergerak dibidang penjualan mebel yang berlokasi di Kota Jambi. Selama ini proses pendataan masih menggunakan cara konvensional yang itu menggunakan kertas. Dengan sistem ini sering terjadi permasalahan yaitu dengan banyaknya data barang, kategori dan warna yang terlalu banyak menyebabkan sulit dalam proses pengontrolan persediaan barang yang dimiliki perusahaan, seringnya terjadi kesalahan dalam pencatatan dan perhitungan nota penjualan, persediaan barang yang sering mengalami selisih dikarenakan proses perhitungan persediaan barang yang masih dihitung secara manual yang menyebabkan terjadi kerugian. Sehingga diperlukannya suatu sistem informasi yang memberikan kemudahan dalam melakukan pencatatan dan pencarian data – data pada CV. Super Makmur Sentosa. Penelitian ini memiliki tahapan yaitu identifikasi masalah, pengumpulan data, analisis sistem, perancangan sistem, dan pembuatan laporan. Sehingga menghasilkan sistem yang dapat memberikan kemudahan dalam pengolahan data persediaan, penjualan, pencarian serta pembuatan laporan, mempermudah pengguna sistem dalam mengontrol data persediaan produk sehingga membantu CV. Super Makmur Sentosa dalam pengolahan data menjadi lebih baik dan teratur.
Perancangan Website Pada La Terra Cafe Jambi Sebagai Media Promosi Dan Informasi
Authors: Syifa Munawarah Syifa Munawarah , Yuliagsa Darma Rezaldy , Anugrah Teguh , Dr. Dodo Zenal Abidin, S.Kom, M.Kom
Published: November 2023

Pemanfaatan teknologi sebagai sarana promosi dan informasi, terutama melalui website telah menjadi media penting dalam penyampaian informasi. Demikian halnya promosi yang di lakukan oleh La Terra café, meskipun telah berhasil memanfaatkan media sosial sebagai alat promosi, namum La Terra café belum meiliki website resmi yang menyediakan informasi lengkap tentang café tersebut. Tujuan perancangan website untuk mempermudah melakukan promosi dan penyampaian informasi serta meningkatkan pemasaran melalui media promosi yang lebih efektif dan efisien. Website ini dirancang menggunakan Bahasa pemprograman PHP dan database MySQL.  Adapun metode yang digunakan adalah model waterfall, serta pendekatan model sistem UML diantaranya use case diagram, activity diagram, dan class diagram. Melalui penelitian ini, diharapkan La Terra café dapat mengoptimalkan pemanfaatan teknologi informasi dalam mempromosikan usaha mereka.
PERANCANGAN SISTEM INFORMASI PENERIMAAN PESERTA DIDIK BARU DI SDN 205 KOTA JAMBI BERBASIS WEB
Authors: Dona Primayu Ekarsih  , Ramadhan M. Dimas , Peri Sandiko Saputra  , Dodo Zaenal Abidin
Published: November 2023

Pendidikan merupakan sebuah sistem yang terencana untuk mewujudkan suasana belajar dan proses pembelajaran atau pelatihan agar peserta didik secara aktif dapat mengembangkan potensi dirinya. Seiring dengan perkembangan sistem informasi yang semakin pesat tentunya dapat membantu bagi sebuah lembaga untuk mendukung dan mempermudah dalam mencapai target dan tujuan lembaga pendidikan itu sendiri. Namun tentunya penggunaan teknologi harus berbasis sistem yang terstruktur sehingga permasalahan dalam sebuah kasus dapat di pecah menjadi sub sistem/bagian/komponen yang saling berkaitan antara satu dengan yang lain dan berhubungan untuk mencapai sebuah tujuan tertentu. Sistem informasi pendaftaraan calon siswa baru berbasis website, merupakan sistem pendaftaraan bagi para calon siswa baru yang ingin melakukan pendaftaran ke sekolah melalui media website, tanpa harus datang langsung ke sekolah, sehingga akan memudahkan bagi para calon siswa baru dalam melakukan proses pendaftaran, sehingga akan lebih menghemat waktu dan tenaga serta dapat meminimalisir proses antrian pendaftaran disekolah. Dari permasalahan tersebut diperlukan aplikasi penerimaan siswa baru berbasis web agar dapat memudahkan panitia dalam proses pendaftaran maupun penyimpanan data-data calon peserta peserta didik baru, bagi calon siswa semoga lebih mudah dalam melakukan proses pendaftaran serta lebih cepat untuk mendapatkan informasi-informasi tentang sekolah.
PERANCANGAN SISTEM INFORMASI PENJUALAN DAN JASA GROOMING PADA LINDA PETSHOP JAMBI
Authors: Afriani Meri , Amroni  , Gusriyanti Dwi Ayu
Published: November 2023

Linda Petshop Jambi merupakan salah satu usaha yang berlokasi di kota Jambi dimana pengelolaan data penjualan produk dan jasa grooming masih menggunakan buku. Sehingga terjadi permasalahan yaitu sulit untuk mengelola produk yang tersedia secara cepat dan akurat, sering terjadi kesalahan dalam pengelolaan jasa, data penjualan atau data produk yang dipakai, lambatnya proses pengolahan dan pencarian data, informasi yang disajikan kurang akurat dan pembuatan laporan yang tidak dapat diselesaikan tepat pada waktunya. Oleh karena itu penelitian ini bertujuan merancang sistem informasi penjualan dan jasa grooming menggunakan bahasa pemograman PHP dan DMBS MySQL. Penelitian ini menggunakan metode pengembangan sistem waterfall dan pemodelan sistem seperti use case diagram, activity diagram, class diagram dan flowchart. Hasil dari penelitian ini adalah sistem yang dapat memberikan kemudahan dalam pengolahan data jasa grooming dan penjualan baik perhitungan, pencarian dan pembuatan laporan, sehingga pengolahan data dan penyebaran informasi menjadi lebih baik dan teratur.

 

Kata Kunci : Sistem, Informasi, Penjualan, Jasa Grooming, Web
PELATIHAN PENGENALAN DAN PENGGUNAAN MIKROKONTROLLER ARDUINO UNO GUNA MENGONTROL LAMPU UNTUK SISWA/I SMK N 7 MUARO JAMBI
Authors: Saputra Chindra , Bustami M. Irwan , Sika Xaverius , Jasmir Jasmir , Zulfikarman Zulfikarman , Toscany Afrizal Nehemia , Yose Imelda , Nugroho M. Restu
Published: November 2023

SMK N 7 Muaro Jambi adalah salah satu SMK terakreditasi B yang memiliki jurusan Teknik Komputer dan Jaringan (TKJ). Permasalahan yang dihadapi pada siswa/i SMK tersebut kurangnya informasi tentang mikrokontroler dan IoT, karena untuk perancangan rangkaian mikrokontroller arduino uno diperlukan pemahaman elektronika dasar dan pemahaman pemograman mikrokontroller itu sendiri agar dapat berjalan sesuai dengan yang diinginkan. Tujuan di laksanakan kegiatan ini adalah memberikan pemahaman penggunaan mikrokontroller Arduino Uno guna mengontrol lampu sehingga di harapkan siswa – siswa di SMK Negeri 7 Muaro Jambi dapat dapat merancang rangkaian sederhana guna untuk mengontrol lampu berbasis Mikrokontroller Arduino Uno. Pelatihan ini berjalan dengan baik, siswa/I dapat merangkai rankaian lampu yang dihubungkan dengan arduino uno seteleh itu mereka dapat memprogram arduino uno dengan bahasa pemograman untuk mengontrol jalan lampu sesuai keinginan mereka
Sistem Informasi Koperasi Berbasis Web Pada Koperasi Pegawai Negeri Dinas Pendapatan Daerah Provinsi Jambi
Authors: Gearidinda Anisa Atlantita , Siahaan Kondar
Published: November 2023

The Jambi Provincial Revenue Service Cooperative is a cooperative managed by Civil Servants at the Jambi Provincial Revenue Service. For now, cooperatives have not used information systems effectively, because cooperatives have not digitally processed data yet. The Design of a Web-Based Cooperative Information System for the Civil Servant Cooperative of the Jambi Provincial Revenue Service uses the PHP programming language and uses object-based modeling techniques to describe system analysis and design, namely in the form of use case diagrams, class diagrams, and activity diagrams. The output of this research is in the form of a prototype design system for Analysis and Design of a Web-Based Cooperative Information System at the Civil Servant Cooperative, Jambi Province Regional Revenue Service. For further research, it can be complemented with other data management.
Sistem Informasi Layanan Pernikahan Berbasis Web Pada Kantor Urusan Agama Mendahara Ilir Tanjung Jabung Timur
Authors: Farista R Rahul , Sharipuddin Sharipuddin
Published: November 2023

A web-based marriage service information system at the religious affairs office of Mendahara Ilir, Tanjung Jabung Timur, an institution that serves marriage registration. The process of marriage services in data collection at the Office of Religious Affairs is currently still being recorded manually by officers. This study aims to analyze and design a marriage service information system at the Mendahara Ilir religious affairs office, Tanjung Jabung Timur. The method used in this study is the waterfall method, the design of this information system produces a prototype using the Unified Modeling Language programming language, the information system designed can facilitate the process of inputting marriage data where the data will be stored in the same database so that the data from the marriage report can be well integrated. The information system created is only limited to the service information system for Marriage Schedule, Marriage Implementation, Marriage Book Publisher and Marriage Book Duplicate.
Can Form-Based Codes be the Opportunity to Achieve a Quality Built Environment in Aotearoa New Zealand?
Authors: van Bruggen Ben
Published: November 2023

This article suggests that our current land-use planning is routinely failing to make good places where people want to live. The inability of land-use zoning to generate mixed-use neighbourhoods is one reason. Instead of land-use and density calculations, the use of form-based codes might be an opportunity to take a holistic approach to streets, buildings and open spaces when thinking about our future neighbourhoods.
PLAYS “THUNDERSTORMˮ BY A.N. OSTROVSKY AND “BITTER FATE” BY A.F. PISEMSKY: SIMILAR MOMENTS OF GRAMMATICAL STYLISTICS IN THE CONTEXT OF THE DEVELOPMENT OF THE RUSSIAN LITERARY LANGUAGE
Authors: Gantsovskaya Nina S. , Qin Lidong
Published: November 2023

The article continues the analysis of conditional conjunctions in the functional and stylistic aspect bookish/colloquial based on plays by A.N. Ostrovsky, whose language in the post-Pushkin period most clearly reflected the democratic trends in the development of the Russian literary language of the mid-19th century, and hypotactical conjunctions served as markers of the language progressive movement. In this regard, a well-known play by A.N. Ostrovsky “Thunderstorm”, winner of 1960 Uvarov Prize, is considered in comparison with the play “Bitter Fate” by A.F. Pisemsky, another award winner of that contest, a writer also associated with Kostroma region. The conclusion is as follows: although the “Thunderstorm” conveys the language of burghers and merchants, in contrast to the peasant language reflected in “Bitter fate”, however, bright signals of the colloquialism of conditional conjunctions against the background of the neutral features of bookishness are clearly distinguished in the style of the vocabulary and syntax of both works and there are many similarities: the use of colloquial or bookish conjunctions in a play mainly depends on the character’s social status and the communication situation. This conclusion comes from another play by A.F. Pisemsky, “Predators”, about the life of the elite bureaucracy, where the bookish conjunction если prevails. The authors of the article state the fact that in the subsequent development of the Russian literary language, the same trend in the development of function words remains.