bluuebunny/crossref_metadata_2025 huggingface dataset:
Peran Lembaga Amil Zakat dalam Meningkatkan Kesejahteraan Keluarga Janda Miskin Melalui Program Kampung Mandiri di Laznas Yatim Mandiri Kudus
Authors: Ramadhanti Firda , Riyadi H. Fuad
Published: February 2021

The purpose of this research is to analyze the role of the Amil Zakat Institution (LAZ) in the economic sector to improve the welfare of poor widowed families, namely through the economic empowerment program of the Kampung Mandiri National Amil Zakat Institute (LAZNAS) Yatim Mandiri, Kudus Branch located in Cangkring B Village, Karanganyar District, Regency. Demak. The results showed that the LAZNAS Yatim Mandiri Kudus Branch program in the formation of the Kampung Mandiri program, namely first, planning the formation of the Kampung Mandiri program in Cangkring B Village Karanganyar Demak to the implementation of the program, with the business being managed is fried onions with the branding "Guemez Onions". Second, the distribution of funds for the Kampung Mandiri program is budgeted at Rp. 128,590,000 for capital and program facilities and infrastructure. Third, monitoring the Kampung Mandiri program. The role of the Kampung Mandiri program for poor widows is first, to provide knowledge of entrepreneurship and Islam. Second, increase entrepreneurial skills. Third, increase income. The role of LAZNAS Yatim Mandiri, Kudus Branch is still not optimal in improving the welfare of poor widow families because the income earned from working wages when the production of fried onions is of little value and the profits from sales cannot be used directly by widows because they are still collected and stored first. The Kampung Mandiri program has been supported by the existence of village approval, grants for program activities, and business capital from LAZNAS Yatim Mandiri Kudus Branch. Meanwhile, the obstacles experienced are the slow rate of development, the production process is not yet optimal, the lack of cohesiveness of the members of Kampung Mandiri, and the marketing of products that are not optimal.
Model Pengelolaan Aset Wakaf Berbasis Profesionalisme Nadzir di Kecamatan Mamajang Kota Makassar
Authors: Rahmania Nurul , Jannah Wardatul , Sofyan A. Syatir
Published: February 2021

This study seeks to provide an overview of an effective strategy for waqf asset management through a model recommendation in Mamajang District, Makasar City. The low quality of human resources, in this case is nadzir in managing waqf assets, causes waqf to be unproductive in Indonesia. Therefore, the purpose of this study is to provide an overview to the parties concerned, in this case waqf, regarding the unproductive nature of waqf in Indonesia so far so that it can be taken into consideration for the increase of waqf in the future. This type of research is descriptive qualitative. The results obtained are Nazhir in the district. Mamajang does not carry out its duties according to the existing law. The donation process carried out in the district. Mamajang is only intended for the construction of religious facilities and there are still waqf lands that have not been certified due to problems with Nazhir in managing land certificates that do not exist.
Validity of the Developmental Coordination Disorder Questionnaire’ 07 and Its Association with Physical Activity in Young Children with Developmental Disabilities
Authors: Ku Byungmo
Published: February 2021

OBJECTIVES The purposes of the current study were to examine the construct and predictive validity, and reliability of the developmental coordination disorder questionnaire’ 07 (DCDQ’ 07) for young children with developmental disabilities (DD).METHODS 135 parents of young children with DD completed an online questionnaire which consisted of demographic information, the DCDQ’ 07, and a physical activity behavior questionnaire. A one-way analysis of variance was conducted to evaluate motor difficulties across different types of young children with DD. Exploratory factor analysis and Cronbach’s alpha were used to examine construct validity and reliability of the DCDQ’ 07. Moreover, hierarchical multiple regression analysis was used to examine the association between the DCDQ’ 07 scores and physical activity behaviors in young children with DD.RESULTS The one-way analysis of variance indicated that the DCDQ’ 07 scores were significantly different across different types of young children with DD = 6.66, p <0.001). The exploratory factor analysis revealed a three-factor solution, accounting for 64.34% of the variance of the DCDQ’ 07. Internal consistencies of the three factors were acceptable. One factor, control during movement, was a significant predictor for physical activity behaviors in young children with DD (β = 0.37, p < 0.01).CONCLUSIONS The DCDQ’ 07 may be a reliable and valid measure in examining motor difficulties in young children with DD. To promote physical activity behaviors in young children with DD, teaching and reinforcing motor skills need to be encouraged.
Effects of a Perturbation-Based Balance Training on Compensatory Postural Responses to Backward Loss of Balance in Patients with Cerebellar Disease: A Case Study
Authors: Im Chang-Ha , Park Jin-Hoon
Published: February 2021

OBJECTIVES The damage to the cerebellum primarily results in balance-related abnormalities that may affect performance of locomotion and postural adjustments, eventually contributing to an increased risk of fall and fear of falling in patients with cerebellar disease. The purpose of the present study was to investigate the effect of a perturbation-based training that induced backward loss of balance on compensatory postural responses in patients with cerebellar disease.METHODS The participant was a 51-year-old female diagnosed with spinocerebellar ataxia and had the disease for 19 years. The perturbation-based backward balance training was performed over 8 weeks (a total of 24 training sessions) in order to facilitate the perception of postural perturbation onset and execution of rapid compensatory responses.RESULTS The patient demonstrated a noticeable reduction in the number of steps required to recover body balance after postural disturbances. The reduction of multi-step reactions in recovering balance could be attributed to improvements in the body center-of-mass displacement and trunk control during the landing of step. Besides, there were also improvements in subjective measures of functional mobility and psychological well-being after the balance training.CONCLUSION Although current research evidence of balance rehabilitation for cerebellar patients is lacking, this study offers the feasibility of adaptive training to improve postural stability through task-specific training intervention.
Eco-efficient cementitious composites with large amounts of waste glass and plastic
Authors: Corbu Ofelia , Bompa Dan V , Szilagyi Henriette
Published: February 2021

This paper presents an experimental study, which has been lacking to date, into the properties and applications of waste glass–plastic cementitious (WGPC) composites incorporating recycled aggregates as a full replacement of natural aggregates, with direct application in highly eco-efficient construction components. Detailed experimental assessments of the fresh properties, strength and durability characteristics of such composites are undertaken. Particular focus is given to the mix rationale and optimisation process as well as possible routes of exploitation of such materials in construction elements. The experimental assessments showed that such composite materials meet the strength and durability criteria for direct application in practice. The best balance in terms of strength and workability was achieved for a waste glass-to-plastic aggregate ratio of 92/8. The presence of relatively large amounts of recycled waste glass particles with small sizes acted as secondary hydration products and contributed to achieving an adequate strength of the material. Besides a lower unit weight and superior thermal properties compared with those of conventional concrete, WGPC components have shown a reliable behaviour under vehicle impact loading and potential wider application in sustainable non-structural construction applications.
Valoración multicéntrica sobre el efecto terapéutico suplementario de los polipéptidos linforeticulares derivados del porcino en el curso clínico de diversas patologías
Authors: Acero Plazas Víctor M. , Higuera Piedrahita Rosa Isabel , Mejía Mejía Guillermo
Published: February 2021

Introducción: los polipéptidos linforeticulares de origen esplénico y hepático porcino han sido postulados como agentes inmunomoduladores en humanos y una alternativa como coadyuvantes en tratamientos contra el cáncer y otras patologías. El objetivo de este estudio fue cuantificar mediante una encuesta dirigida a individuos especializados sobre el uso de los polipéptidos linforeticulares de origen porcino, como tratamiento y coadyuvante en diversas patologías.Metodología: 136 médicos y profesionales de la salud, de alta calificación ético-profesional, ubicados en trece ciudades de Colombia, participaron en un estudio multicéntrico, retrospectivo, valorativo, basado en una encuesta sustentada en una escala de Likert (rango 1-9) en la que se pretende valorar el “efecto terapéutico suplementario” de los polipéptidos linforeticulares (low molecular weight –L.M.W–), desarrollados en este país y observados en el curso clínico de múltiples patologías, así como la aceptación de estos nuevos compuestosen la práctica médica corriente.Resultados: se reportaron un total de 6.510 pacientes vistos y tratados durante un periodo comprendido entre los seis meses anteriores o más de tres años, en una revisión de casuística. Los resultados demuestran un interés general de todos los segmentos y disciplinas de la medicina por estos compuestos orgánicos y reconocen su utilidad en la práctica médica holística y ortodoxa. El 100 % de los investigadores asociados valoraron el efecto terapéutico de estos péptidos específicos, y los clasificaron con valores entre 7 y 9, es decir; (7) como bueno (33,8 %), (8) entre bueno y excelente (34,5 %) y (9) como excelente (26,4 %), reportaron también algunos casos excepcionales.Conclusiones: con base en los resultados se sugiere el uso de estos péptidos como coadyuvantes en el tratamiento de diversas patologías humanas.
Variabilidad de la frecuencia cardiaca de ciclistas de pista hombres comparado con mujeres durante un test incremental
Authors: Porras Alvarez Javier , Puerta Guarin Mariana Catalina , Ávila Correa Fernando Javier
Published: February 2021

Introducción: Este estudio muestra las diferencias en la variabilidad de la frecuencia cardiaca (VFC) entre hombres y mujeres ciclistas profesionales, durante un test máximo incremental. Objetivo: Evaluar la VFC en ciclistas profesionales hombres y mujeres de pista durante un test máximo incremental de 12min. Métodos: Participaron 18 ciclistas profesionales que compiten en pruebas de pista, 7 mujeres edad: 22±5.9 años; años de entrenamiento 5.8±2.9 y 11 hombres edad: 21.4±4.4 años; años de entrenamiento 6.7±3.3. El test incremental para hombres inició con 100 vatios e incrementos de 50 vatios hasta 300 vatios, luego incrementos de 20 vatios, cada 2 minutos, cadencia pedaleo 75-90 rpm. Las mujeres iniciaron con 50 vatios, incrementos de 50 vatios hasta 200 vatios, luego incrementos de 20 vatios, cada 2 minutos, cadencia pedaleo 65-80 rpm. Resultados: Primera etapa, no existió diferencia significativa de la VFC entre los grupos. Segunda etapa, RMSSD fue mayor significativamente en las mujeres. Tercera etapa, LF/HF fue significativamente mayor en hombres. Cuarta a sexta etapa, no existió diferencia significativa en la VFC. Durante el primer minuto de recuperación, no existió diferencia significativa de la VFC. Conclusiones: Durante un test incremental en ciclistas entrenados en velocidad se observan diferencias significativas en la VFC pero a diferentes intensidades de ejercicio entre hombres y mujeres. En cambio, a la misma intensidad de ejercicio no existen diferencias significativas en la VFC, al igual que en el primer minuto de recuperación. Esto indica que en la evaluación de la VFC donde se incluyan hombres y mujeres el protocolo del test incremental debe ser exactamente el mismo.
The Argument and Semantic Structures of Japanese Verb Give
Authors: Oeinada I Gede , Beratha Ni Luh Sutjiati , Sudipa I Nengah , Satyawati Made Sri
Published: February 2021

This study examines four Japanese synonymous verbs that have the same equivalent in English, namely GIVE. These four Japanese synonymous verbs are ageru, kureru, kizou suru, and kifu suru. This study used a qualitative descriptive method. Example sentences for the data were taken from Balance Corpus of Contemporary Written Japanese corpus data. The theories applied in this study are argument structure theory and Natural Semantic Metalanguage theory. Based on the analysis, there were selectional restrictions found in the argument structure of these synonymous verbs that can be used to distinguish one verb from another. In addition, these synonymous verbs, although there are some overlapping meaning components, have distinctive meaning components belonging to each verb. Therefore, it can be said that these synonymous verbs cannot fully replace each other in all contexts.
Research on Pre-service English Teachers' Professional Ability Development Preference Based on MALL
Authors: Li Junshui , Gao Miaomiao , Tu Xifang
Published: February 2021

Mobile-Assisted Language Learning (MALL) provides a new method and view for pre-service English teachers to improve their professional ability. Through the questionnaire survey of 105 students majoring in English in colleges and universities, using SPSS20.0 to carry out descriptive statistics on the effective data collected, analyzing the data of their maximum value, mean value and single sample t test, this paper discusses the preference of different pre-service English teachers to improve their different professional abilities by using mobile devices. It is found that pre-service English teachers pay more attention to the improvement of English professional knowledge with the support of mobile devices, followed by teaching skills, and the lowest attention to the use of mobile devices to improve their teacher professional quality. Therefore, the purpose of this study is to find out the lack of pre-service English teachers' preference to improve their ability through mobile technology, which provides a new learning idea and inspiration for the future English teachers to polish their own professional skills.
Study on Lin Shu’s Translation Style and Its Formation
Authors: Yang Lihua
Published: February 2021

Lin Shu brought the style of elegance and succinctness of the ancient Chinese prose into his translation, but he also tried his best to convey the style of the original to readers. When rendering various original styles, he naturally brought the “inelegant” and “insuccinct” elements into the translation, thus weakening elegance and succinctness to some extent. Nevertheless, the “elegant and succinct” elements in his translation was maintained at a relatively high proportion as a whole, so his translation style could still be categorized as that of “elegance and succinctness”. In terms of its dynamic formation, it was closely related to the translator, target readers and translation cultural strategy. To be specific, Lin Shu’s good command of classical Chinese prose, the stylistic preference of traditional literati and scholar bureaucrats, as well as the translation cultural strategy of assimilating the foreign languages with Chinese style, all contributed to the formation of Lin’s translation style.
The Investigation of the Effects of Agmatine in Pentylenetetrazole-induced Epilepsy Model in Mice and the Contribution of Nitric Oxide
Authors: AYDIN Sule , TOPRAK Çiğdem , ÇENGELLİ ÜNEL Çiğdem , KAYGISIZ Bilgin , EROL Kevser
Published: February 2021

Objective: Agmatine is an endogenous cationic amin and have been reported several neurotherapeutic effects through α2-adrenoceptors, imidazoline binding sites, inhibition of NMDA receptors and nitric oxide (NO) synthase. NO was reported to act as a neuromodulator and neurotransmitter in central nervous system and has proconvulsant/anticonvulsant activities in convulsion models. We aimed to compare the anticonvulsant activities of agmatine, sodium valproate, gabapentin and phenytoin, and to investigate the role of NO in effects of drugs.
Material and Methods: Epilepsy seizures were induced in swiss-albino mice by single dose injection of penthylenetetrazole (PTZ) (60 mg/kg). Myoclonic-jerk (MJ) and generalized tonic-clonic seizures (GTCS) of mice were recorded. Agmatine (10 mg/kg), sodium valproate (150 mg/kg), gabapentin (20 mg/kg) and phenytoin (20 mg/kg) alone or in combinations with N(G)-Nitro-L-arginine-methyl-ester (L-NAME, 5 mg/kg), the precursor of NO, L-arginine (L-Arg, 60 mg/kg) and non-specific NO synthase inhibitor, were injected intraperitoneally.
Results: While agmatine and sodium valproate significantly prevented GTCS%, phenytoin and gabapentin did not prevent. L-Arg significantly reduced activity of agmatine on MJ%. Both L-Arg and L-NAME did not affect activity of phenytoin on MJ% and GTCS%. L-Arg did not change the activity of gabapentin on MJ% and GTCS%. L-NAME significantly increased activity of gabapentin on MJ% and GTCS%.
Conclusion: This study suggested that NO may have a role on anticonvulsant activity of agmatine and gabapentin but not those of sodium valproate and phenytoin.
Muğla Orman Bölge Müdürlüğü idari sınırlarında yayılış gösteren endemik bitki taksonlarının güncel durumu
Authors: ÖNER Hafize Handan , ÖZEL Nihal , ALTUN Nuran , YANMADIK Yüksel
Published: February 2021

Bu araştırmada, Muğla Orman Bölge Müdürlüğü idari sınırları içinde yayılış gösteren endemik bitki taksonlarının güncel durumunun belirlenmesi amaçlanmıştır.

Bu doğrultuda öncelikle ilgili literatürler taranarak çalışma alanında kaydedilen endemik bitki taksonları belirlenmiş ve listelenmiştir. Sonrasında çalışma tüm alanda tarama olarak gerçekleştirilmiştir. Arazi çalışmaları sırasında; söz konusu taksonların bulunduğu noktaların koordinatları, yükselti, anakaya, habitat ve mevkii özellikleri kaydedilmiştir.

Yapılan çalışma sonucunda, Muğla Orman Bölge Müdürlüğü idari sınırları içinde yayılış gösteren 39 familya ve 132 cinse mensup toplam 368 adet endemik vasküler bitki taksonu belirlenmiştir. Belirlenen bu taksonların IUCN durumları ve CITES kapsamları ayrıca incelenmiştir. Buna göre çalışma alanında tespit edilen endemik taksonların 321’inin bir IUCN değerine sahip olduğu ve 2 adedinin ise CITES kapsamında yer aldığı görülmüştür.

Ayrıca bu çalışma sonucunda 29 familya ve 49 cinse mensup olmak üzere, toplam olarak 83 adet endemiklikten çıkarılan takson kaydedilmiştir.
Idősek városképe – egy városmárka-asszociációs kutatás korcsoportspecifikus eredményei
Authors: Kovács László , Zsarnóczky Martin , Keller Krisztina , Tóth-Kaszás Nikoletta
Published: February 2021

A települési kutatások aktuális területét képezik a márkázással kapcsolatos elemzések, melyek a településeket – településmárka címszó alatt – a márkamenedzsment szemszögéből vizsgálják. Bár összefoglaló néven településmárkáról beszélhetünk, ez a legtöbb esetben városok márkázását jelenti. Jelen kutatásban a településmárkából, mint az elmében létrejövő entitásból indulunk ki. Ezzel Aaker (1991) és Keller (1998) mellett Sebastian Zenker városmárkákkal kapcsolatos kutatásai jelentik a vizsgálat kiindulópontját – elsősorban a Zenker és Braun (2017) által megalkotott modell, amely a település márkáját a tudatunkban a településhez kapcsolódó asszociációkként értelmezi.

Kutatásunkban egy városmárka és a „fogyasztó” kapcsolatát asszociációs módszerrel vizsgáltuk meg: a lakosoknak a városmárka nevéhez kötődő asszociációit elemeztük. A vizsgálat tárgya Nagykanizsa, a vizsgálat alanya pedig egy konkrét csoport, a Nagykanizsán élő idős generáció.

Az asszociációk alapján kirajzolódó aktuális kép megmutatja, hogy milyen jellemzők nehezítik és / vagy könnyítik meg az idősek mindennapjait a városban. Az eredmények alapján jellemezzük az idősek várossal kapcsolatos képét, majd rámutatunk arra, hogy az idős generáció tagjai amellett, hogy a város egy korábbi, általuk ismert képét hívják elő, a következő generációk szükségleteit is szem előtt tartják. A gyűjtött asszociációk alapján Zenker és Braun (2017) településasszociációkkal kapcsolatos modelljét is módosítjuk. A tanulmány végén javaslatokat fogalmazunk meg, amelyek felhasználásával Nagykanizsa idős lakossága jobban integrálhatóvá válhat a város mindennapjaiba.
Az örök falu – hanyatlás és fentmaradás. A községi népesség számának a változása
Authors: Balogh Karolina , Kovách Imre
Published: February 2021

A tanulmány célja a községi népességszám változásának elemzése a rendszerváltozástól 2016-ig terjedő időszakban. A kutatás céljának megvalósításához új települési szintű adatbázisba rendeztük a KSH és a TEIR adatait. Az elemzés a községi népesség abszolút számának alakulását, valamint a változatlan közigazgatási besorolású községek adatait is magában foglalja, valamint röviden bemutatja a városi státuszt elnyerő települések népességének változását is. Tanulmányunk a települések, és ezek közül a falvak népességváltozásának hosszú időtartamú trendjeiről szól, és bemutatja az 1995 és 2016 között mindvégig községi státuszú települések vándorlási és demográfiai folyamatait, a népességdinamikai változásokat, a települések fejlettségi dimenzióinak és a népességszám változásának összefüggéseit. A tanulmány alapjául szolgáló elemzések rámutatnak az abszolút községi népességszám nagymértékű csökkenésére, ugyanakkor a községi besorolású települések népességének nagyfokú stabilitására is. Tanulmányunk elemzi a népesség szerinti faluosztályok között végbemenő erőteljes vándorlási folyamatokat, valamint a vándorlás hátterében álló legfontosabb motiváló erőket is. A falvak legnagyobb népességvesztése a 152 várossá nyilvánítás következménye. A folyamatosan községi besorolású falvak népességének a csökkenése csak három százalék körüli, ugyanakkor a „község” kategóriához tartozó települések között jelentős vándorlás történt. A kisfalvak lakossága gyorsuló ütemben csökken, a nagyobb falvakba vándorol, és ez a folyamat mind a nagyobb községek, mind az aprófalvak társadalmának szerkezetét és életesélyeit átalakítja.
Olmesartan modulates proliferating cell nuclear antigen expression and improves dextran sulfate: induced ulcerative colitis in rats
Authors: Emam Hanan Tawfeek , Ibrahim Amany N.
Published: February 2021

Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by sudden attacks of remissions and exacerbations with increased incidence of cancer colon. The present study aims to determine the possible ameliorative mechanisms of Olmesartan in UC induced experimentally in rat.Methods: Adult albino rats were randomly grouped into control, UC model non treated group: Rats received dextran sodium (DSS) orally for 21 days with intra-colic administration of acetic acid (AA) for 3 consecutive days for induction of UC model, Olmesartan (1, 5, 10mg/kg/orally) and UC + Olmesartan in different doses (1 mg, 5 mg and 10 mg/kg/day orally).Results: DSS orally and AA intra-rectal produced sever colitis manifested by significant weight loss, watery and bloody diarrhea. Significant increase in serum and colonic tissue levels of tumor necrosis factor alpha and interleukine-1β. Pro-apoptotic Bax protein, myeloperoxidase (MPO) and expression of PCNA significantly increased in colonic tissue. Lipid peroxidation (MDA) significantly elevated while reduced glutathione (GSH) was depleted in UC non-treated group compared with normal control group. Treatment with Olmesartan (5 mg, 10 mg/kg/day, orally) ameliorated mucosal ulceration and improved inflammatory signs as confirmed by immunohistochemical and histopathological examination. Also, Olmesartan significantly attenuates overexpression of PCNA in colonic mucosa.Conclusions: Our results point out that Olmesartan had ameliorative effects on UC by its anti-inflammatory, antioxidant and anti-apoptotic effects and attenuates PCNA expression which is the main cause of dysplasia and colorectal cancer. Olmesartan may be a promising therapeutic drug for treating UC and protection of colorectal carcinoma.
Repurposing of chloroquine and hydroxychloroquine for the management of COVID-19
Authors: Gberindyer Fidelis A. , Shima Felix K. , Bosha Joel A. , Ahur Victor M. , Swem Festus T. , Abatan Matthew O.
Published: February 2021

The Coronavirus Disease-19 (COVID-19) pandemic has impacted adversely on the global health and socio-economic activities. There is currently no evidence-based anti-SARS-CoV-2 drug for COVID-19 therapy. This review highlights some pharmacological properties of chloroquine and hydroxychloroquine and prospects of repurposing them for the treatment of COVID-19. Google scholar was employed in searching relevant published journal articles (n=118) in English. The search was later narrowed down to SARS-CoV-2, pathophysiology of COVID-19, available drugs for the management of COVID-19, clinical trials on repurposing drugs for COVID-19 therapy, and the role of chloroquine and hydroxychloroquine in the treatment of COVID-19. Documented evidence revealed that chloroquine and hydroxychloroquine have antiviral and immune-modulatory properties. Their antiviral effect is due to inhibition of the spike proteins of SARS-CoV-2 from binding to the cellular transmembrane receptors, angiotensin converting enzyme-2 thereby preventing viral infections. Also, sequestration of these drugs into the lysosomes elevates lysosomal pH thus inhibiting lysosomal enzymatic functions vital for viral replication in those cells. Whereas, their immune-modulatory activity averts the inflammatory complications of COVID-19, particularly acute respiratory syndrome, by preventing cytokine storm through suppression of the production and putative release of pro-inflammatory cytokines. The adverse effects from these drugs, notably irreversible retinopathy and cardiac arrhythmia are rare but become life-threatening when they occur. These are minimal with hydroxychloroquine compared to chloroquine. Chloroquine and hydroxychloroquine could be repurposed for managing COVID-19 cases because they are already extensively used for treating acute nonresistant malaria and auto-immune diseases. Also, a viable vaccine cannot be available in the near future while there is a pressing need for treatments to lower the daily rise in morbidity and mortality associated with the disease. Nevertheless, we suggest that emphasis should be on hydroxychloroquine because of its superior antiviral effect and clinical safety.
Prevalence and associated risk factors of superficial and cutaneous mycoses among children attending Halibet referral hospital in Asmara, Eritrea
Authors: Prabakaran John J. , Kesete Yordanos , Yohannes Eyob , Tsehaye Eyorusalem , Teklezghi Natsnet , Araya Eyorusalem , Arefaine Winta
Published: February 2021

Background: Superficial and cutaneous mycoses are very common among the populations in many African countries. Even though it has not been regarded as a significant problem since the disease is not life-threatening, it may be particularly distressing for the children. The aim of this study was to identify important etiologic agents, proportion of clinical manifestations and related risk factors of superficial and cutaneous mycoses.

Methods: A case control prospective study was conducted among children of age 4-14 from January to June, 2017.A total of 240 children were included in the study. Out of these 120 children who visited Orotta Pediatric hospital for cases apart from skin infections were used as control group and the remaining 120 were children suspected with fungal skin infection who attended Halibet referral hospital. Nail, skin and scalp scrapings were collected and subjected for microscopic examination and culture-based laboratory diagnosis. The associated risk factors which can lead to skin mycoses were also analysed.

Results: Among 120 suspected cases, 87.5% children were positive for superficial cutaneous mycoses out of which 59.2% were males and 40.8% were females. The most prevalent dermatophyte observed was Trichophyton verrucosum (15.2%) whereas Trichosporon sp. (40%) was predominant among non-dermatophytes. Most of the infections occurred between age groups 4-6 (32.5%). Tinea capitis was the most common disease (57.5%) among the cutaneous mycotic infections, whereas white Piedra (40%) was predominant among the superficial mycotic infections. The important risk factors were intimate association with livestock or pet (50%), playing with children having skin infection (73.3%), sharing of beds (92.5%), sharing of combs (75.3%) and sharing of towels (80.1%).

Conclusions: The present study clearly shows that tinea capitis was the predominant clinical finding in children and T. verrucosum was the most common fungus among dermatophytes. At least five risk factors were statistically significant out of all. So public health workers should give attention for increasing the knowledge of society regarding the mode of transmission of skin mycoses, hygiene behaviour and associated risk factors.
Cutaneous manifestations in patients with chronic kidney disease on hemodialysis
Authors: Gupta Saijal , Talanikar Hemant V. , Deora Mahendra S. , Agrawal Ankita , Sharma Yugal K.
Published: February 2021

Background: Chronic kidney disease (CKD) is associated with several cutaneous manifestations as a result of CKD per se, underlying disease(s) leading to it or the treatment thereof. Cutaneous manifestations get altered following hemodialysis. We studied the prevalence of various dermatoses and the effect on pruritus in patients with CKD on hemodialysis.

Methods: Seventy-three patients with CKD having at least one cutaneous manifestation undergoing hemodialysis in Dr. D.Y. Patil Medical College, Hospital and Research Centre, Pune were included.

Results: Sixty-four (87.67%) of the participants belonged to the age group of 40-69 years; 28 (38.35%), to the sixth decade. The male to female ratio was 1.8:1. Forty-eight patients (65.75%) suffered from diabetes mellitus, 37 of these also from hypertension. Xerosis (72.6%), pallor (65.8%) and pruritus (60.3%) were the common manifestations. The intensity of pruritus remained unchanged in 82% of those affected. Nail changes were seen in 47.9% cases (half-and-half nail, 19.2%; subungual hyperkeratosis, 11%; leukonychia, 6.8%; melanonychia, 6.8%; Beau’s lines, 4.1%). Infections were observed in 32.8% cases (superficial mycoses, 19.2%; bacterial, 6.8%; scabies, 4.1%; viral, 2.7%). Dyspigmentation was documented in 30.1% (hyperpigmentation, 21.92%; yellow tinge, 8.22%), hair changes in 23.3% (sparse scalp hair,16.4%; lusterless hair, 6.9%), acquired perforating dermatoses in 19.2%, and arteriovenous shunt dermatitis in 2.7% cases.

Conclusions: Xerosis was the commonest finding and pruritus, the commonest symptom; the intensity of the latter remained largely unaffected by hemodialysis. Half-and-half nail was the most common nail change and superficial mycoses, the most common infection.

 
Familial leiomyoma: a case report
Authors: Gutha Swetha , Sampath Shalini
Published: February 2021

Cutaneous leiomyomas are benign tumors that can be exquisitely painful. Comprise three distinct types such as piloleimyoma, angioleiomyoma, and genital leiomyoma. Piloleiomyomas, derived from arrector pili muscle, are solitary or multiple firm papulonodules located mostly on the extremities and trunk; genital leiomyomas, derived from dartoic, vulvar, or mammary smooth muscle, are solitary or papulonodules located on the scrotum, vulva, or nipple; and angioleiomyomas, include solid, cavernous, or venous subtypes, are derived from the tunica media of small arteries and veins and typically present on the extremities. Excisional biopsy is required for diagnosing all cutaneous leiomyomas Histology shows interlacing fibers of spindle cells with moderate amounts of eosinophilic cytoplasm and a blunt-ended, elongated nucleus with perinuclear halos. Surgical excision is curative for cutaneous leiomyomas, with other management options including medical or destructive therapy. A 36-year-old male patient presented with a 13 years history of painful, multiple lesions over the back. Based on the histopathological examination, imaging, and past medical records, a diagnosis of familial leiomyoma was made. His brother had similar disease. The patient was started on tab gabapentin 300mg at night. Patient advised for carbon dioxide laser excision. The present case report has been reported for its interesting clinical presentations and rarity.
Lineamientos para la implementación de sistemas de recaudo interoperables para transporte público
Authors: Camós Gibet , Gordillo Fabio , Palacio Adriana
Published: February 2021

La masificación de los sistemas de transporte, debido al crecimiento de la población y las ciudades, ha generado la necesidad de implementar sistemas de recaudo electrónico para mejorar su eficiencia operativa, y poder controlar y fiscalizar adecuadamente sus ingresos. Esta publicación presenta principios y condiciones técnicas, operativas y de seguridad, recomendados para el diseño de un sistema de recaudo para servicios de movilidad, con el fin de garantizar su interoperabilidad y flexibilidad. Asimismo, expone unos lineamientos generales que se recomiendan sean aplicados por las autoridades para el desarrollo de sistemas que permitan la interacción de distintos medios de pago y múltiples proveedores tecnológicos y/o de servicios. Se definen lineamientos específicos para la implementación de diferentes medios de pago: tarjetas bancarias sin contacto que satisfacen el estándar Europay Mastercard Visa (EMV), tarjeta de transporte, códigos de barras 2D y efectivo con validación electrónica. Para ilustrar estos lineamientos, se desarrollan casos de estudio de la puesta en marcha de los medios de pago en diferentes países: Costa Rica, Paraguay y República Dominicana.
Collaborative Amphia Science C19: Optimizing COVID-19 research in the Netherlands
Authors: Annemarie JBM de Vos  , Leandra JM Boonman-de Winter  , Henriëtte FEW Cuijpers  , Denise Eygendaal
Published: February 2021

Since March 2020 the Amphia Hospital, Breda in the Netherlands has been at the forefront of patient care during the COVID-19 pandemic. To assist health professionals and researchers we initiated a task force to optimize COVID-19 related research by coordinating COVID-19 related scientific projects and promoting collaboration between the different disciplines in the Amphia Hospital. Within the task force three separate teams were formed with their own dedicated tasks and responsibilities in the development and use of the COVID-19 database. Approximately fifty COVID-19 related studies have started in the Amphia Hospital. In addition, we participated in a variety of clinical trials for COVID-19-treatment and executed retrospective and observational studies. Moreover, the Amphia Hospital collaborated in national and international cohorts and initiatives because of our COVID-19 database. The joint effort to optimize COVID-19 related research in the Amphia Hospital contributed to improved interdisciplinary collaboration, and promoted new initiatives regarding interdisciplinary research. The task force members experienced equality and professional acknowledgment through the establishment of the Amphia COVID-19 Collaborative Group.
The CYP2R1 Enzyme: Structure, Function, Enzymatic Properties and Genetic Polymorphism
Authors: Dong Amelia Nathania , Tan Boon Hooi , Pan Yan , Ong Chin Eng
Published: February 2021

Since the discovery of its role in vitamin D metabolism, significant progress has been made in the understanding of gene organisation, protein structure, catalytic function, and genetic polymorphism of cytochrome P450 2R1 (CYP2R1). Located on chromosome 11p15.2, CYP2R1 possesses five exons, unlike most other CYP isoforms that carry nine exons. CYP2R1 crystal structure displays a fold pattern typical of a CYP protein, with 12 a-helices as its structural core, and b-sheets mostly arranged on one side, and the heme buried in the interior part of the protein. Overall, CYP2R1 structure adopts a closed conformation with the B′ helix serving as a gate covering the substrate access channel, with the substrate vitamin D3 occupying a position with the side chain pointing toward the heme group. In liver, CYP2R1 25-hydroxylates vitamin D and serves as an important determinant of 25(OH)D level in the tissue and in circulation. While substrate profile has been well studied, inhibitor specificity for CYP2R1 requires further investigation. Both exonic and non-exonic single nucleotide polymorphisms (SNPs) have been reported in CYP2R1, including the CYP2R1*2 carrying Leu99Pro exchange, and a number of non-exonic SNPs with variable functional consequences in gene regulation. A non-exonic SNP, rs10741657, has its causal relationship with diseases established, including that of rickets, ovarian cancer, and multiple sclerosis. The role of other CYP2R1 SNPs in vitamin D deficiency and their causal link to other traits however remain uncertain currently and more studies are warranted to help identify possible physiological mechanisms underlying those complex traits.
Coronavirus disease 2019 (COVID-19) manifestations during pregnancy in all three trimesters: A case series
Authors: Askary Elham , Tahereh Poordast , Shiravani Zahra , Ali Ashraf Mohammad , Hashemi Atefeh , Naseri Razieh , Moradialamdarloo Shaghayegh , Karimi Zinat , Izanloo Elham , Sadat Najib Fatemeh
Published: February 2021

Background: Coronavirus disease 2019 (COVID-19) pandemic has raised concerns about the susceptibility amongst different groups of the population. Pregnant women are one such group. This study was conducted to investigate the effect of COVID-19 on pregnancy and maternal/neonatal outcomes.
Case presentation: This case series was conducted on 16 pregnant women with COVID-19 from March 21 to May 11, 2020. Clinical characteristics, pregnancy complications, medication used, maternal/neonatal outcomes, and fatality rate were investigated through this study. The mean age of the patients was 30.06 yrs. Patients from all three trimesters were included (1 in first, 5 in second, and 10 in the third trimesters). The most common clinical symptoms were shortness of breath (n = 10), dry cough (n = 10), myalgia (n = 8), and chills (n = 7). Also, three cases had papulosquamous skin lesions with fissuring. The most common laboratory results were leukocytosis (n = 8), increased liver enzymes (n = 6), elevated CRP (n = 5), and thrombocytopenia (n = 4). There was one case of maternal mortality, five of premature labor pain (PLP), two of preeclampsia, and two of placenta accreta. Twelve pregnancies were terminated (nine cesarean sections, three vaginal deliveries). Among neonates, we had 6 cases of preterm labor. All neonates had negative PCR results.
Conclusion: Clinical manifestations and paraclinical results were similar to nonpregnant patients. There was no evidence of vertical transmission. PLP and premature rupture of membranes (PROM) were the most common complications in the second and third trimesters of pregnant COVID-19 women, which can lead to rupture of the uterus. Termination and delivery should be planned individually.
Key words: Pregnancy, COVID-19, Maternal-fetal infection transmission, Vertical transmission of infectious disease, Papulosquamous skin diseases.
A Comparative Study of Chlorophyll Content Estimation in Barley (Hordeum vulgare L.) Genotypes Based on RGB (Red, Green, Blue) Image Analysis
Authors: Guendouz Ali , Bendada Hocine , Benniou Ramadan
Published: February 2021

Background: Chlorophyll is the most important pigment in plant which absorbs light and subsequently transfers its energy to drive the photochemical reactions of photosynthesis. The numerical image processing techniques have been widely used in the analysis of leaf characteristics. Methods: The methods based on RGB (Red, Green and Blue) image analysis may emerge as a new and low-cost method for estimation the chlorophyll content. In this work, we use eight RGB vegetation indices as alternative for chlorophyll content estimation. Result: The student t-test showed that all the RGB indices tested are suitable to estimate the chlorophyll content in barley genotypes. In addition, the results which based on the correlation analysis in combination with the values of root mean squared error (RMSE) demonstrate that the very suitable RGB indices are these with high values of correlation coefficient and lowest values of RMSE. Data collected from barley genotypes leaves indicated that digital image processing technology can be a useful and rapid non-destructive method for assessment of chlorophyll content. Among the RGB indexes tested in this study the 100-(2R-B) and RGRI (R/G) are the most promising index to estimate the chlorophyll content in barley genotypes.
Al-Adab Al- ‘Araby Fi Fatrah Intiqal Al- Hukmi Min Khilafah Al- Umawiyyah Ila Khilafah Al-‘Abbasiyyah (Dirasah Washfiyyah Tarikhiyyah Adabiyyah)
Authors: Chotimah Dien Nur
Published: February 2021

The period of Arab literature was divided into the political age, the pre-Islamic period, the Islamic era, the Umayyad era, the Abbasia era, the Andalusian era, the era of the Mamalik, and the modern era. Because of the Umayyah caliphate and the Abbasia caliphate, the long period of politics extends. Political problems emerged from within the caliphate and therefore have a lot to do with Arab literature. The researcher used the descriptive and historical method. The result of this research on the characteristics of the Arabic literature in the period between the Umayyah and Abbasia Caliphate, are: 1) The poetry expresses the conditions obtained from the historical facts of war, 2) encouraging in its later stages, 3) the use of clear words and structures in the body Poem and poetry.Keywords: Arab literature, period of transition of government, Umayyah caliphate, Abbasih caliphate
Uso de tecnologias digitais no processo de documentação do patrimônio
Authors: Oliveira Adriana Freire de , Scharffhausen Jean-Baptiste , Lapa Tomás Albuquerque
Published: February 2021

O presente artigo busca aprofundar o debate sobre o uso das tecnologias digitais no processo de documentação do vilarejo de Thillois, situado no nordeste da França. Trata-se de um patrimônio construído, quase totalmente destruído, durante a Primeira Guerra Mundial, que foi objeto de uma verdadeira reconstrução no pós-guerra. A análise proposta tem como objetivo esclarecer de que forma essas tecnologias têm permitido o acesso a documentos de época, além de enriquecer a documentação que foi produzida durante o desenvolvimento da pesquisa, revelando detalhes do patrimônio antes e depois da reconstrução. Desse modo, espera-se contribuir tanto para o processo de registro desse patrimônio, quanto para o reconhecimento do seu legado.
POVOS ORIGINÁRIOS E TRATADOS DE DIREITOS HUMANOS: Efetividade e Possibilidades à Luz da Constituição de 1988
Authors: Rodrigues Marco Antônio , Cavararo Rodrigues Andréa Lúcia , Colman Rosa Sebastiana
Published: February 2021

O presente trabalho buscará analisar a formação dos Estados nacionais e seu impacto sobre as populações originárias, especificamente o povo Guarani e Kaiowá da região fronteiriça do Estado do Mato Grosso do Sul, haja vista o Brasil ser signatário da Convenção nº 169/OIT e a proteção aos direitos dos povos originários contida no artigo 231 da Constituição Federal de 1988. Diante dessa hipótese, o artigo irá investigar alguns dos motivos pelos quais a efetividade desses direitos se encontra comprometida e suas consequências sobre a população estudada. Partindo-se do referencial teórico de Norberto Bobbio, a conquista de direitos é um caminho contínuo, que tende ao reconhecimento dos direitos do cidadão perante o mundo. Adotando-se a base metodológica da complexidade de Edgar Morin, buscou-se investigar o problema de forma interdisciplinar e transversalmente, analisando-se o fenômeno em suas várias acepções, chegando à conclusão parcial de que a ineficácia constitucional tem contribuído para a inefetividade das normas internacionais, comprometendo a esfera de direitos dos povos originários. A partir do método indutivo e através da pesquisa bibliográfica, histórica, antropológica e jurisprudencial, o artigo buscará chegar ao resultado esperado.
RESPONSABILIDADE CIVIL EM DECORRÊNCIA DE ALIENAÇÃO PARENTAL DE IDOSOS
Authors: Bueno Nayana Guimarães Souza de Oliveira Poreli , Marques Oacilene  Alves Maciel
Published: February 2021

A alienação parental de idosos, ou alienação parental inversa, não conta com regramento legislativo específico, embora existam casos de alienação praticada por filhos, cuidadores ou pessoas próximas ao idoso, que geram danos tanto a este, quanto à pessoa alienada do convívio do idoso. O objetivo do trabalho é estudar se o alienador pode ser responsabilizado civilmente pela prática da alienação inversa e em que situações ocorre essa responsabilização. A hipótese é a de que surge a responsabilidade civil do alienador quando se constata a violação do dever de proteção do idoso, com a prática de condutas previstas na Lei nº 12.318/2010, lei esta que, embora regulamente a alienação parental praticada em face de crianças e adolescentes, pode ser aplicada analogicamente no caso de alienação inversa. Para alcançar esse fim, utilizou-se o método dedutivo, partindo de premissas gerais para alcançar uma conclusão específica. O procedimento de pesquisa foi a consulta à legislação, especialmente à Constituição Federal de 1988, ao Código Civil, ao Estatuto do Idoso (Lei nº 10.741/2003) e à Lei de Alienação Parental (Lei nº 12.318/2010), bem como consulta à doutrina e à jurisprudência sobre o tema. Ao final, a hipótese foi confirmada, verificando-se a possibilidade de responsabilização do alienador em casos de alienação inversa, através da fixação de indenização por danos morais causados à pessoa alienada e ao idoso.

PALAVRAS-CHAVE: Idoso; Alienação Parental Inversa; Responsabilidade Civil.

 

ABSTRACT

 

Parental alienation of the elderly, or inverse parental alienation, does not have specific legislative rules, although there are cases of alienation practiced by children, caregivers or people close to the elderly, which cause damage to both estudothe alienated person and the elderly themselves. The purpose of this research is to study if the alienator can be held civilly responsible for the practice of reverse alienation. The hypothesis is that the alienator's civil liability arises when it occurs the violation of the duty to protect the elderly, with the practice of conduct foressen in Law No. 12.318/2010, which, although regulating parental alienation practiced in the face of children and adolescents, can be applied analogously in the case of reverse alienation. To reach the objective, the deductive method was used, starting from general premises to reach a specific conclusion. The research procedure was to consult the legislation, especially the Federal Constitution of 1988, the Civil Code, the Elderly Statute (Law No. 10.741 / 2003) and the Parental Alienation Law (Law No. 12.318 / 2010), as well as the doctrine and the jurisprudence. In the end, the hypothesis was confirmed, concluding by the alienator’s liability in cases of reverse alienation, by setting compensation for moral damages caused to the alienated person and the elderly.

 

KEYWORDS: Elderly; Inverse Parental Alienation; Civil Responsability.