bluuebunny/crossref_metadata_2025 huggingface dataset:
Survey on Machine Learning Biases and Mitigation Techniques
Authors: Siddique Sunzida , Haque Mohd Ariful , George Roy , Gupta Kishor Datta , Gupta Debashis , Faruk Md Jobair Hossain
Published: December 2023

Machine learning (ML) has become increasingly prevalent in various domains. However, ML algorithms sometimes give unfair outcomes and discrimination against certain groups. Thereby, bias occurs when our results produce a decision that is systematically incorrect. At various phases of the ML pipeline, such as data collection, pre-processing, model selection, and evaluation, these biases appear. Bias reduction methods for ML have been suggested using a variety of techniques. By changing the data or the model itself, adding more fairness constraints, or both, these methods try to lessen bias. The best technique relies on the particular context and application because each technique has advantages and disadvantages. Therefore, in this paper, we present a comprehensive survey of bias mitigation techniques in machine learning (ML) with a focus on in-depth exploration of methods, including adversarial training. We examine the diverse types of bias that can afflict ML systems, elucidate current research trends, and address future challenges. Our discussion encompasses a detailed analysis of pre-processing, in-processing, and post-processing methods, including their respective pros and cons. Moreover, we go beyond qualitative assessments by quantifying the strategies for bias reduction and providing empirical evidence and performance metrics. This paper serves as an invaluable resource for researchers, practitioners, and policymakers seeking to navigate the intricate landscape of bias in ML, offering both a profound understanding of the issue and actionable insights for responsible and effective bias mitigation.
Single-Cell Transcriptome Analysis of Acute Myeloid Leukemia Cells Using Methanol Fixation and Cryopreservation
Authors: Madaci Lamia , Gard Charlyne , Nin Sébastien , Sarrabay Alexandre , Baier Céline , Venton Geoffroy , Rihet Pascal , Puthier Denis , Loriod Béatrice , Costello Régis
Published: December 2023

Introduction: The application of single-cell RNA sequencing has greatly improved our understanding of various cellular and molecular mechanisms involved in physiological and pathophysiological processes. However, obtaining living cells for this technique can be difficult under certain conditions. To solve this problem, the methanol fixation method appeared as a promising alternative for routine clinical use. Materials and Methods: In this study, we selected two AML samples that had been fixed in methanol for 12–18 months. Once the cells were rehydrated, these samples were subjected to single-cell RNA sequencing. We then compared the results obtained from these samples with those obtained from the same samples cryopreserved in DMSO. Results: We used a previously validated methanol fixation protocol to perform scRNA-seq on DMSO cryopreserved cells and cells fixed in methanol for more than one year. Preliminary results show that methanol fixation induces some genetic and transcriptional modification compared with DMSO cryopreservation but remains a valuable method for single-cell analysis of primary human leukemia cells. Conclusions: The initial findings from this study highlight certain resemblances in methanol fixation over a 12-month period and cryopreservation with DMSO, along with associated transcriptional level modifications. However, we observed genetic degradation in the fixation condition when extending beyond one year. Despite certain study limitations, it is evident that short-term methanol fixation can be effectively used for leukemia blast samples. Its ease of implementation holds the potential to simplify the integration of this technique into routine clinical practice.
Reflections on Distance in Remote Placement Supervision: Bodies, Power, and Negative Education
Authors: Munday Ian , Heinz Manuela , Gallagher Brenda
Published: December 2023

School placement plays a critical and complex role in the professional development of student teachers. When universities and schools shut their doors and moved all teaching activities online in March 2020, initial teacher education (ITE) providers across Ireland had to implement emergency alternative practicum supports in order to ensure that students could complete their ITE programmes. Many initial teacher education providers across Ireland introduced professional online conversations as an alternative approach to professional practice supervision. It is easy to view this response to the COVID-19 crisis in purely deficit terms. For obvious reasons, no sensible teacher educator would advocate for abandoning school visits and replacing them with online professional conversations. Nonetheless, emergency measures arguably brought about affordances to the delivery of teacher education, which are deserving of consideration and may help to inform future practice. In this paper, we draw on our recent experience of ITE emergency practicum supervision to explore assumptions and tensions inherent in traditional teacher education practices. We reflect on how we enacted and experienced professional student–tutor conversations without the normally preceding classroom observations and interrogate normalised assumptions about the value and purpose of classroom observation. Our reflections are infused with ideas gleaned from philosophy and sociological theory and are underpinned by a theoretical formulation which we call “negative education”. “Negative education” refers to the learning that takes place as a consequence of deprivation. In these terms, we come to examine the negotiation of power and relationships in different learning environments. We explore the benefits of “zooming out”, to disseminate power, and show how this helps to engage with the broader aspects of teaching which are so easily overlooked by both tutors and students during “normal” school visits.
The Excellent Bending Limit of a Flexible Si-Based Hf0.5Zr0.5O2 Ferroelectric Capacitor with an Al Buffer Layer
Authors: Xie Xinyu , Qi Jiabin , Wang Hui , Liu Zongfang , Wu Wenhao , Lee Choonghyun , Zhao Yi
Published: December 2023

Flexible Si-based Hf0.5Zr0.5O2 (HZO) ferroelectric devices exhibit numerous advantages in the internet of things (IoT) and edge computing due to their low-power operation, superior scalability, excellent CMOS compatibility, and light weight. However, limited by the brittleness of Si, defects are easily induced in ferroelectric thin films, leading to ferroelectricity degradation and a decrease in bending limit. Thus, a solution involving the addition of an ultra-thin Al buffer layer on the back of the device is proposed to enhance the bending limit and preserve ferroelectric performance. The device equipped with an Al buffer layer exhibits a 2Pr value of 29.5 μC/cm2 (25.1 μC/cm2) at an outward (inward) bending radius of 5 mm, and it experiences a decrease to 22.1 μC/cm2 (16.8 μC/cm2), even after 6000 bending cycles at a 12 mm outward (inward) radius. This outstanding performance can be attributed to the additional stress generated by the dense Al buffer layer, which is transmitted to the Si substrate and reduces the bending stress on the Si substrate. Notably, the diminished bending stress leads to a reduced crack growth in ferroelectric devices. This work will be beneficial for the development of flexible Si-based ferroelectric devices with high durability, fatigue resistance, and functional mobility.
Satellite-Assisted Disrupted Communications: IoT Case Study
Authors: Koukis Georgios , Tsaoussidis Vassilis
Published: December 2023

In recent years, the space industry has witnessed a resurgence, characterized by a notable proliferation of satellites operating at progressively lower altitudes, promising extensive global coverage and terrestrial-level data transfer speeds, while remaining cost-effective solutions. In particular, Wireless Sensor Networks (WSNs) can benefit from the wide coverage of space infrastructure due to their extensive deployment, disrupted communication nature, and the potential absence of terrestrial support. This study explored the utility of Low-Earth Orbit (LEO) satellite constellations as a communication infrastructure for interconnecting “smart” devices via ground stations in Internet of Things (IoT) scenarios. To this end, we designed and implemented a series of experiments conducted within the OMNeT++ simulator, utilizing an updated iteration of the original Open Source Satellite Simulator (OS3) framework. Our research encompassed an IoT Case Study, incorporating authentic sensor data sourced from the Smart Santander testbed. Throughout our experimentation, we investigated the impact of the constellation design parameters such as the number of satellites and orbital planes, as well as the inter-satellite link configuration on the obtained Round-Trip Time (RTT) and packet loss rates.
Influence Analysis and Control Method of Ultra-Low Frequency Oscillation in a Hydro-Dominant Sending Power System with Wind Power Integration
Authors: Chen Gang , Zeng Xueyang , Shi Huabo , Wang Biao , Li Gan , Jiang Qin , Wang Yongfei , Li Baohong
Published: December 2023

To make clear the influence of renewable energy on ultra-low-frequency oscillation (ULFO) in a hydro-dominant system via an high voltage direct current (HVDC) transmission system, this paper studies the damping characteristics when wind power is integrated into the sending power system. The damping torque method is applied for the mechanism study and risk evaluation of ULFO. The study of the inner cause and outer performance proves that ULFO belongs to frequency oscillation rather than conventional power oscillation. According to the theoretical analysis, the suggested control mode is identified to reduce the risk of ULFO. Moreover, a robust controller is designed for wind units based on mixed H2/H∞ robust control theory, and the control method makes use of the fast response ability of the converter without compromising the primary frequency regulation ability. Finally, a simulation model of a hydro-dominant sending power system with wind integration is established in PSCAD Version 4.6 software. The simulations verify the proposed control can suppress ULFO effectively.
Exploring the Impact of Fermentation on Brown Rice: Health Benefits and Value-Added Foods—A Comprehensive Meta-Analysis
Authors: Lim Min-Jin , Barathikannan Kaliyan , Jeong Ye-Jin , Chelliah Ramachandran , Vijayalakshmi Selvakumar , Park Seon-Ju , Oh Deog-Hwan
Published: December 2023

The escalating global incidence of obesity and chronic diet-related disorders, such as type 2 diabetes, hypertension, cardiovascular disease, malignancies, and celiac disease, has intensified the focus on dietary factors and disease risks. Rice, a dietary staple for billions, is under scrutiny, particularly polished or white rice, which is high in starch and in the glycemic index and low in nutrition due to the removal of the outer bran layer during milling. This study critically analyzes the comparison between whole brown rice (BR) and milled white rice in terms of health benefits. A significant finding is the enhancement of food nutrition through fermentation, which improves protein digestibility and mineral availability and releases peptides and amino acids. The study also highlights the increased antibacterial and antioxidant activity of foods, including health benefits, through fermentation. A comprehensive review of existing data on the nutritional content and health advantages of whole fermented BR grains is presented, alongside experiments in developing fermented BR-based foods. The safety, preservation, and the economic and environmental advantages of consuming regularly fermented BR instead of white or unfermented BR are discussed. Finally, the paper addresses the commercialization challenges and future opportunities for promoting fermented BR as a healthier food alternative.
An Image-Based Fire Monitoring Algorithm Resistant to Fire-like Objects
Authors: Xu Fang , Zhang Xi , Deng Tian , Xu Wenbo
Published: December 2023

Due to its wide monitoring range and low cost, visual-based fire detection technology is commonly used for fire detection in open spaces. However, traditional fire detection algorithms have limitations in terms of accuracy and speed, making it challenging to detect fires in real time. These algorithms have poor anti-interference ability against fire-like objects, such as emissions from factory chimneys, clouds, etc. In this study, we developed a fire detection approach based on an improved YOLOv5 algorithm and a fire detection dataset with fire-like objects. We added three Convolutional Block Attention Modules (CBAMs) to the head network of YOLOv5 to improve its feature extraction ability. Meanwhile, we used the C2f module to replace the original C2 module to capture rich gradient flow information. Our experimental results show that the proposed algorithm achieved a mAP@50 of 82.36% for fire detection. In addition, we also conducted a comparison test between datasets with and without labeling information for fire-like objects. Our results show that labeling information significantly reduced the false-positive detection proportion of fire-like objects incorrectly detected as fire objects. Our experimental results show that the CBAM and C2f modules enhanced the network’s feature extraction ability to differentiate fire objects from fire-like objects. Hence, our approach has the potential to improve fire detection accuracy, reduce false alarms, and be more cost-effective than traditional fire detection methods. This method can be applied to camera monitoring systems for automatic fire detection with resistance to fire-like objects.
The Effect of Turbidity on the Behavior of Bleak (Alburnus alburnus)
Authors: Horka Petra , Vlachova Monika
Published: December 2023

In group-living species, social interactions with conspecifics play a crucial role in group formation and the ability to make consensus decisions, with far-reaching consequences for ecological and evolutionary processes in natural populations. Individual recognition and partner preferences based on social familiarity are important mechanisms driving a range of interactions between individual fish and social structure in fish populations. However, the social interactions of gregarious species are also influenced by the ecological environment experienced by individuals. This study aimed to determine how fish shoals’ structure is shaped by increased turbidity, a typical environmental constraint in anthropogenically impacted rivers. A freshwater, shoal-forming, visually orientated pelagic fish—bleak (Alburnus alburnus)—was used as the model organism. The behavior of 40 individuals at three different turbidity levels (0 NTU, 30 NTU, 60 NTU) was tested in the laboratory experiment. Specifically, the aim was to determine if the turbidity reduces between individual distances in response to the deteriorated visual conditions. The results showed that bleaks increased the compactness of the shoal even at the medium turbidity level (30 NTU), and compactness further increased with turbidity. Such results indicate that turbidity is an important phenomenon influencing the structure of shoals and ultimately an ecological process in natural fish populations in ecosystems affected by increasing turbidity.
Antibacterial Activity of Dihydroquercetin Separated from Fructus Polygoni orientalis against Clavibacter michiganensis subsp. sepedonicus via Damaging Cell Membrane
Authors: Cai Jin , Wang Shiqin , Wang Qi
Published: December 2023

The yield and quality of potato can be severely affected by bacterial ring rot, which is caused by Clavibacter michiganensis subsp. sepedonicus (Cms). Recently, using natural compounds to control bacteria has received more attention. In this study, five antibacterial compounds from ethyl acetate (EtOAc) extract of Fructus Polygoni orientalis (FPO) against Cms were isolated and the most active compound was screened. Five active compounds were identified as 3,3′-di-O-methylellagic acid (1), 3,3′-di-O-methylellagic acid-4-O-β-D-glucopyranoside (2), dihydroquercetin (3), protocatechuic acid (4) and quercetin (5). Compound 3 (dihydroquercetin, DHQ) was confirmed as the most active compound. The diameter of inhibition zone (DIZ), minimum inhibitory concentration (MIC), protective efficiency and curative efficiency of DHQ were 22.50 mm, 0.313 mg/mL, 84.49% and 79.63%, respectively, which exceeded these of thiophanate-methyl (TM) in antibacterial activity assays; this indicated that DHQ had satisfactory antibacterial activities against Cms in vitro and in vivo. Results of cell membrane damage assessments indicated that DHQ could reduce membrane potential (MP), disrupt the cell membrane integrity, and promote the leakage of nucleic acids and proteins. Overall, these findings suggested that DHQ could serve as a promising lead molecular against Cms, which could provide a basis for its further derivatization.
Eating Quality of Australian Grass and Grain-Fed Lamb Equally Rated by US Consumers
Authors: Corlett Maddison T. , Pannier Liselotte , Gardner Graham E. , Garmyn Andrea J. , Miller Mark F. , Pethick David W.
Published: December 2023

Anecdotal suggestions that US consumers perceive Australian sheepmeat as more “gamey” or “stale” compared to US sheepmeat are potentially attributable to the extended chilled shipping times contributing to longer-aged meat and predominately pasture-fed grazing systems. This study evaluated the impact of diet and extended storage times on Australian sheepmeat using sensory scores as assessed by US consumers. Meat samples from Australian sheep (n = 80) fed a grass or grain diet were aged in a vacuum at 1–2 °C for 5, 21 or 45 days. Untrained consumers (n = 960) at Texas Tech University (Lubbock, Texas) assessed samples for overall liking, tenderness, juiciness and flavour using a scale from 1 (worst) to 100 (best). In general, US consumers scored grain- and grass-fed samples within the same storage period similarly (p > 0.05). Furthermore, storage from 5 to 21 days improved sensory scores by a maximum of 28.6 for tenderness for grass-fed outside cuts (p < 0.05), while storage for 21 to 45 days did not improve eating quality for most cuts of both diets (p > 0.05). This is an interesting finding for the Australian sheepmeat industry as long storage time has no negative effect on eating quality and US consumers enjoyed grass- and grain-fed sheepmeat equally.
Impact of Prior Pulsed Electric Field and Chitooligosaccharide Treatment on Trypsin Activity and Quality Changes in Whole and Beheaded Harpiosquillid Mantis Shrimp during Storage in Iced Water
Authors: Chanchi Prashanthkumar Mallikarjun , Temdee Wattana , Mittal Ajay , Suyapoh Watcharapol , Sornying Peerapon , Palamae Suriya , Bautong Jirayu , Zhang Bin , Hong Hui , Benjakul Soottawat
Published: December 2023

Harpiosquillid mantis shrimp (Harpiosquilla raphidea) (HMS) without and with beheading pretreated with pulsed electric field (PEF) (15 kV/cm, 800 pulses, 5 min) were soaked in chitooligosaccharide (COS) solution at varying concentrations (0, 1 and 2%, w/v) for 20 min and stored for 3 days in iced water. Changes in the trypsin activity, color, texture, protein pattern, TCA soluble peptide content, histological images, protein secondary structure and microbial load were monitored during the storage. The beheaded HMS pretreated with PEF and soaked in 2% COS solution showed the maximum efficacy in inhibiting trypsin activity and proteolysis, thus retaining muscle proteins, especially myosin heavy chain, actin and troponin T as well as shear force up to day 3. Pronounced muscle destruction in the whole HMS was displayed by a decreased mean grey index and fiber gapping. Such changes were lowered by the beheading and PEF/2% COS treatment (2% COS-BH). Nevertheless, no marked change in the secondary structure including α-helix, β-sheets, β-turns and random coil were observed among any of the samples. The microbiological analysis revealed that the total viable count (TVC) was below 6 log CFU/g till day 2 in all samples. Nonetheless, the 2% COS-BH sample had the lowest psychrophilic bacterial count and Enterobacteriaceae count at day 3, compared to the others. Thus, the combination of the prior PEF and 2% COS treatment of beheaded HMS could effectively inhibit proteases, retard the microbial growth and maintain the quality of HMS stored in iced water.
Advancements in Downscaling Global Climate Model Temperature Data in Southeast Asia: A Machine Learning Approach
Authors: Amnuaylojaroen Teerachai
Published: December 2023

Southeast Asia (SEA), known for its diverse climate and broad coastal regions, is particularly vulnerable to the effects of climate change. The purpose of this study is to enhance the spatial resolution of temperature projections over Southeast Asia (SEA) by employing three machine learning methods: Random Forest (RF), Gradient Boosting Machine (GBM), and Decision Tree (DT). Preliminary analyses of raw General Circulation Model (GCM) data between the years 1990 and 2014 have shown an underestimation of temperatures, which is mostly due to the insufficient amount of precision in its spatial resolution. Our findings show that the RF method has a significant concordance with high-resolution observational data, as evidenced by a low mean squared error (MSE) value of 2.78 and a high Pearson correlation coefficient of 0.94. The GBM method, while effective, had a broader range of predictions, indicated by a mean squared error (MSE) score of 5.90. The Decision Tree (DT) method performed the best, with the lowest mean squared error (MSE) value of 2.43, which closely matched the actual data. The first General Circulation Model (GCM) data, on the other hand, exhibited significant forecast errors, as evidenced by a mean squared error (MSE) value of 7.84. The promise of machine learning methods, notably the Random Forest (RF) and Decision Tree (DT) algorithms, in improving temperature predictions for the Southeast Asian region is highlighted in the present study.
Two Sets of Boundary Conditions in Cyclical Systems with Goodwill in Capitalization
Authors: Kärenlampi Petri P.
Published: December 2023

Mathematical analysis is conducted on cyclical systems with goodwill in capitalization. Proportional goodwill vanishes with vanishing tangible value. Correspondingly, periodic boundary condition does not enable commercial utilization of the goodwill. Abandoning the periodic boundary condition enables commercial utilization of the goodwill. Even if a physical system is periodic, an agent can abandon the corresponding boundary condition by divesting. Example cases are shown in terms of boreal forestry systems.
Stability Analysis of Finite Time for a Class of Nonlinear Time-Delay Fractional-Order Systems
Authors: Ben Makhlouf Abdellatif , Mchiri Lassaad , Rhaima Mohamed
Published: December 2023

In this study, we delve into the examination of Finite Time Stability (FTS) within a specific class of Fractional-Order Systems (FOS) with time delays. By applying a fixed-point theorem, we establish novel sufficient conditions to ensure FTS for time-delayed FOS within  1<σ<2. Moreover, we investigate the existence and uniqueness of global solutions for this particular system. To demonstrate the credibility of our results, we substantiate our findings through the presentation of two illustrative examples.
A Supramolecular Reinforced Gel Fracturing Fluid with Low Permeability Damage Applied in Deep Reservoir Hydraulic Fracturing
Authors: Huang Yongping , Yao Xinlong , Dai Caili , Wu Yining , Li Lin , Yuan Bin
Published: December 2023

Gel fracturing fluid is the optimum fracturing fluid for proppant suspension, which is commonly applied in deep reservoir hydraulic fracturing. The content of polymers and crosslinkers in gel fracturing fluid is usually high to meet the needs of high-temperature resistance, leading to high costs and reservoir permeability damage caused by incomplete gel-breaking. In this paper, a supramolecular reinforced gel (SRG) fracturing fluid was constructed by strengthening the supramolecular force between polymers. Compared with single network gel (SNG) fracturing fluid, SRG fracturing fluid could possess high elasticity modulus (G′ = 12.20 Pa) at lower polymer (0.4 wt%) and crosslinker (0.1 wt%) concentrations. The final viscosity of SRG fracturing fluid was 72.35 mPa·s, meeting the temperature resistance requirement of gel fracturing fluid at 200 °C. The gel-breaking time could be extended to 90–120 min using an encapsulated gel breaker. Gel particles are formed after the gel fracturing fluid is broken. The median particle size of gel particles in the SRG-breaking solution was 126 nm, which was much smaller than that in the industrial gel (IDG) breaking fluid (587 nm). The damage of the SRG-breaking solution to the core permeability was much less than the IDG-breaking solution. The permeability damage of cores caused by the SRG-breaking solutions was only about half that of IDG-breaking solutions at 1 mD.
In Situ Hydrogel Formulation for Advanced Wound Dressing: Influence of Co-Solvents and Functional Excipient on Tailored Alginate–Pectin–Chitosan Blend Gelation Kinetics, Adhesiveness, and Performance
Authors: Amante Chiara , Falcone Giovanni , Aquino Rita P. , Russo Paola , Nicolais Luigi , Del Gaudio Pasquale
Published: December 2023

Chronic skin wounds affect more than 40 million patients worldwide, representing a huge problem for healthcare systems. This study elucidates the optimization of an in situ gelling polymer blend powder for biomedical applications through the use of co-solvents and functional excipients, underlining the possibility of tailoring microparticulate powder properties to generate, in situ, hydrogels with advanced properties that are able to improve wound management and patient well-being. The blend was composed of alginate, pectin, and chitosan (APC). Various co-solvents (ethanol, isopropanol, and acetone), and salt excipients (sodium bicarbonate and ammonium carbonate) were used to modulate the gelation kinetics, rheology, adhesiveness, and water vapor transmission rate of the gels. The use of co-solvents significantly influenced particle size (mean diameter ranging from 2.91 to 5.05 µm), depending on the solvent removal rate. Hydrogels obtained using ethanol were able to absorb over 15 times their weight in simulated wound fluid within just 5 min, whereas when sodium bicarbonate was used, complete gelation was achieved in less than 30 s. Such improvement was related to the internal microporous network typical of the particle matrix obtained with the use of co-solvents, whereas sodium bicarbonate was able to promote the formation of allowed particles. Specific formulations demonstrated an optimal water vapor transmission rate, enhanced viscoelastic properties, gel stiffness, and adhesiveness (7.7 to 9.9 kPa), facilitating an atraumatic removal post-use with minimized risk of unintended removal. Microscopic analysis unveiled that porous inner structures were influencing fluid uptake, gel formation, and transpiration. In summary, this study provided valuable insights for optimizing tailored APC hydrogels as advanced wound dressings for chronic wounds, including vascular ulcers, pressure ulcers, and partial and full-thickness wounds, characterized by a high production of exudate.
Assessment Tools for Measuring Health Literacy and Digital Health Literacy in a Hospital Setting: A Scoping Review
Authors: Dijkman Eline M. , ter Brake Wouter W. M. , Drossaert Constance H. C. , Doggen Carine J. M.
Published: December 2023

Assessment of (digital) health literacy in the hospital can raise staff awareness and facilitate tailored communication, leading to improved health outcomes. Assessment tools should ideally address multiple domains of health literacy, fit to the complex hospital context and have a short administration time, to enable routine assessment. This review aims to create an overview of tools for measuring (digital) health literacy in hospitals. A search in Scopus, PubMed, WoS and CINAHL, following PRISMA guidelines, generated 7252 hits; 251 studies were included in which 44 assessment tools were used. Most tools (57%) were self-reported and 27% reported an administration time of <5 min. Almost all tools addressed the domain ‘understanding’ (98%), followed by ‘access’ (52%), ‘apply’ (50%), ‘appraise’ (32%), ‘numeracy’ (18%), and ‘digital’ (18%). Only four tools were frequently used: the Newest Vital Sign (NVS), the Short Test of Functional Health Literacy for Adults ((S)TOFHLA), the Brief Health Literacy Screener (BHLS), and the Health Literacy Questionnaire (HLQ). While the NVS and BHLS have a low administration time, they cover only two domains. HLQ covers the most domains: access, understanding, appraise, and apply. None of these four most frequently used tools measured digital skills. This review can guide health professionals in choosing an instrument that is feasible in their daily practice, and measures the required domains.
Congenital Muscular Torticollis—Current Understanding and Perinatal Risk Factors: A Retrospective Analysis
Authors: Płomiński Janusz , Olesińska Jolanta , Kamelska-Sadowska Anna Malwina , Nowakowski Jacek Józef , Zaborowska-Sapeta Katarzyna
Published: December 2023

Introduction: Congenital muscular torticollis (CMT) is an asymmetrical head position resulting from structural changes in the sternocleidomastoid (SCM) muscle that occurs early during a child’s development or due to perinatal trauma. Children with CMT exhibit a marked imbalance in tension between the SCMs. In a typical clinical picture, an ultrasound scan is performed to reveal characteristic lesions, such as tissue fibrosis or post-traumatic changes. An early diagnosis of CMT in newborns and the implementation of treatment offer the chance of a complete resolution. Torticollis treatment aims to restore the SCM’s normal function. Surgical treatment is performed when conservative methods fail to improve the patient’s condition. The indications that surgery is needed include a marked shortening of the SCM, persistent fibrosis in the muscle, constant head and facial asymmetry, and rotation or lateral flexion in the cervical spine restricted by >15°. Of all the newborn and infant anomalies, congenital torticollis is the third most common after hip dysplasia and equinovarus deformities. Some authors demonstrate that torticollis coexists with hip dysplasia. Aim: The aim of this study was to collect data on infants referred to paediatric rehabilitation and to identify the risk factors associated with CMT in this group of patients, as well as to assess demographic and clinical characteristics concerning risk factors. Materials and methods: The target population for this retrospective study consisted of 111 infants aged 0 to 5 months born in Poland and diagnosed with and undergoing treatment due to CMT. The following were determined: the relationship between the side of the CMT location and the type of delivery (caesarean section vs. vaginal), the relationship between the body weight at birth and the side of the CMT location, the relationship between the extent of SCM thickening and the type of delivery, and the incidence of CMT depending on the order of delivery. Results and conclusions: The data revealed that CMT is less common in female infants (n = 51, 46%) compared to male (n = 61, 54%) infants, in whom a greater birth weight was reported (p < 005). Seventy-six percent (76%) of the paediatric patients with CMT were the offspring of primipara mothers. More often, children born via vaginal delivery had left-sided torticollis with a more significant broadening of the SCM, as shown on ultrasound scans, than right-sided torticollis. Theories of torticollis development pathophysiology should be deepened and systematised, and further research is needed.
The Effects of Digital Addiction on Brain Function and Structure of Children and Adolescents: A Scoping Review
Authors: Ding Keya , Shen Yining , Liu Qianming , Li Hui
Published: December 2023

The escalating prevalence of studies investigating digital addiction (DA) and its detrimental impact on the human brain’s structure and functionality has been noticeable in recent years. Yet, an overwhelming majority of these reviews have been predominantly geared towards samples comprising college students or adults and have only inspected a single variant of DA, such as internet gaming disorder, internet addiction disorder, problematic smartphone use, tablet overuse, and so forth. Reviews focusing on young children and adolescents (ages 0–18), or those which amalgamate various types of DA, are decidedly scarce. Given this context, summarizing the effects of DA on brain structure and functionality during the vital developmental stage (0–18 years) is of immense significance. A scoping review, complying with the PRISMA extension for such reviews, was conducted to amalgamate findings from 28 studies spanning a decade (2013–2023) and to examine the influence of assorted forms of DA on the brains of children and adolescents (0–18 years). The synthesized evidence indicated two primary results: (1) DA exerts harmful effects on the structure and functionality of the brains of children and adolescents, and (2) the prefrontal lobe is the region most consistently reported as impacted across all research. Furthermore, this review discerned a notable void of studies investigating the neural indices of digital addiction, along with a shortage of studies focusing on young children (0–6 years old) and longitudinal evidence. This research could provide the necessary theoretical basis for the thwarting and intervention of digital addiction, a measure indispensable for ensuring healthy brain development in children and adolescents.
Usefulness of a Multicomponent Group Intervention Program for Fibromyalgia Patients in Primary Care: A Qualitative Study of Health Professionals
Authors: Caballol Angelats Rosa , Aguilar Martín Carina , Carrasco-Querol Noèlia , Abellana Rosa , González Serra Gemma , Gràcia Benaiges Dolors , Sancho Sol Maria Cinta , Fusté Anguera Immaculada , Chavarria Jordana Susana , Berenguera Anna , Gonçalves Alessandra Queiroga
Published: December 2023

Objective: To explore the perceptions and experiences of health professionals who participated in a multicomponent program for fibromyalgia (FM) patients based on health education, physical exercise and cognitive–behavioral therapy. Methods: In this qualitative, descriptive study that was based on a pragmatic and utilitarian approach, we conducted two focus groups (FGs) with 12 professionals (nurses and general practitioners) from the primary healthcare system of Spain who had been trained as FM experts. A thematic content analysis was carried out. Results: The findings were organized into four key domains, each with explanatory emerging themes. Overall, the professionals positively valued the program for the knowledge gain it offered, its integrated approach, the group effect and other benefits to patients. Work overload and peers’ lack of acknowledgement of the program’s value were identified as barriers. A reduction in the amount of content in each session, the creation of quality-of-care indicators and the promotion of the new professional role (FM expert) were proposed. Conclusions: The FM experts supported the program and recognized its usefulness. To implement the program within the primary healthcare system, the program needs to be adjusted to accommodate professionals’ and patients’ reality, and institutional health policies must be improved by providing training on FM to the healthcare community.
Physiological and Transcriptional Analysis Provides Insights into Tea Saponin Biosynthesis and Regulation in Response to SA in Camellia vietnamensis Huang
Authors: Li Yang , Yan Heqin , Zeeshan Ul Haq Muhammad , Liu Ya , Wu Yougen , Yu Jing , Xia Pengguo
Published: December 2023

Camellia vietnamensis Huang is an important and famous woody oil crop with high economic value in China because of its high-quality, edible, and medicinal oil. As one of its major active components, tea saponin (triterpenoid saponin) has shown anticancer, antioxidant, bacteriostatic, and other pharmacological activities. In this study, C. vietnamensis was used as an experimental material to determine the tea saponin content and physiological activity indicators after salicylic acid (SA) treatment and to analyze the differential expression genes of key metabolic pathways in response to SA by combining transcriptome data. The results showed that SA treatment increased the content of tea saponin and total phenols in leaves; effectively promoted the activity of superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), and ascorbate peroxidase (APX); and decreased the content of malondialdehyde (MDA). A total of 60,038 genes, including 5871 new genes, were obtained by the RNA-seq. There were 6609 significantly differential expression genes mainly enriched in pathways such as sesquiterpenoid and triterpenoid biosynthesis, terpenoid backbone biosynthesis, diterpenoid biosynthesis, and flavonoid biosynthesis. The SA-induced key structural genes (SQS, SQE, bAS, CYP450, and UGT) and transcription factors related to the tea saponin biosynthetic pathway were screened by weighted gene co-expression network analysis (WGCNA). The results of this study could provide a theoretical basis and a new technical method to improve the content of tea saponin, with its excellent anticancer activity, in C. vietnamensis.
Cloud-Based Platforms for Health Monitoring: A Review
Authors: Machorro-Cano Isaac , Olmedo-Aguirre José Oscar , Alor-Hernández Giner , Rodríguez-Mazahua Lisbeth , Sánchez-Morales Laura Nely , Pérez-Castro Nancy
Published: December 2023

Cloud-based platforms have gained popularity over the years because they can be used for multiple purposes, from synchronizing contact information to storing and managing user fitness data. These platforms are still in constant development and, so far, most of the data they store is entered manually by users. However, more and better wearable devices are being developed that can synchronize with these platforms to feed the information automatically. Another aspect that highlights the link between wearable devices and cloud-based health platforms is the improvement in which the symptomatology and/or physical status information of users can be stored and syn-chronized in real-time, 24 h a day, in health platforms, which in turn enables the possibility of synchronizing these platforms with specialized medical software to promptly detect important variations in user symptoms. This is opening opportunities to use these platforms as support for monitoring disease symptoms and, in general, for monitoring the health of users. In this work, the characteristics and possibilities of use of four popular platforms currently available in the market are explored, which are Apple Health, Google Fit, Samsung Health, and Fitbit.
Parasitism and Suitability of Trichogramma chilonis on Large Eggs of Two Factitious Hosts: Samia cynthia ricini and Antheraea pernyi
Authors: Zhang Yue-Hua , Xue Ji-Zhi , Tariq Talha , Li Tian-Hao , Qian He-Ying , Cui Wen-Hui , Tian Hao , Monticelli Lucie S. , Desneux Nicolas , Zang Lian-Sheng
Published: December 2023

Trichogramma, an effective biological control agent, demonstrates promise in environmentally sustainable pest management through its parasitic action toward insect eggs. This study evaluates the parasitism fitness and ability of T. chilonis with regard to two factitious host eggs, aiming to develop a cost-effective biological control program. While T. chilonis demonstrated the ability to parasitize both host eggs, the results indicate a preference for ES eggs over COS eggs. The parasitism and emergence rates of T. chilonis regarding ES eggs (parasitism: 89.3%; emergence: 82.6%) surpassed those for COS eggs (parasitism: 74.7%; emergence: 68.8%), with a notable increase in the number of emergence holes observed in the ES eggs compared to the COS eggs. Moreover, the developmental time of T. chilonis for ES eggs (10.8 days) was shorter than that for COS eggs (12.5 days), resulting in a lower number of dead wasps produced. Notably, no significant difference was observed in the female ratios between the two species. A comprehensive analysis was conducted, comparing the size and shell thickness of the two factitious hosts. The ES eggs exhibited smaller dimensions (length: 1721.5 μm; width: 1178.9 μm) in comparison to the COS eggs (length: 2908.8 μm; width: 2574.4 μm), with the ES eggshells being thinner (33.8 μm) compared to the COS eggshells (47.3 μm). The different host species had an effect on the body length of the reared parasitoids, with T. chilonis reared on COS hosts exhibiting a larger body length (female: 626.9 µm; male: 556.7 µm) than those reared on ES hosts (female: 578.8 µm; male: 438.4 µm). Conclusively, the results indicate that ES eggs present a viable alternative to COS eggs for the mass production of Trichogramma species in biological control programs.
Reproductive Safety Issues of Novel Small Molecules for the Treatment of Inflammatory Bowel Disease: A Systematic Review
Authors: Monfared Niloufar , Gold Matthew , Carbery Isabel , Laube Robyn , Selinger Christian P.
Published: December 2023

Maintenance of remission during pregnancy is vital for women with inflammatory bowel disease (IBD). The antenatal safety of novel small molecules for IBD is yet to be ascertained. We aimed to describe the current evidence on reproductive data regarding small-molecule drugs. We performed a systematic review searching Embase Classic + Embase and Ovid MEDLINE for reproductive outcomes for tofacitinib, filgotinib, upadacitininb, and ozanimod. Additionally, we asked the manufacturers for available data on file regarding reproduction. We analysed data from 10 sources; six studies and four manufacturer reports were identified from our search. Significant malformation risks were reported for tofacitinib, filgotinib, upadacitininb, and ozanimod in animal studies. In 126 tofacitinib-exposed pregnancies, there were 55 live births with 2 congenital malformations and 1 serious infant infection, 14 terminations, 15 miscarriages, and 42 outcomes unknown. In 50 filgotinib-exposed pregnancies, there were 20 healthy babies, 1 congenital malformation, 9 terminations, 10 miscarriages, and 10 outcomes unknown. In 78 upadacitinib-exposed pregnancies, there were 30 healthy babies, 15 terminations, 15 miscarriages, and 18 outcomes unknown. In 60 ozanimod-exposed pregnancies, there were 31 live births with 1 congenital malformation, 1 case of intra-uterine growth restriction, 1 case of neonatal icterus, 13 terminations, 9 miscarriages, and 8 unknown outcomes. Animal data suggest significant risks of malformations for tofacitinib, filgotinib, upadacitininb, and ozanimod. Human data from clinical trials and real-world observations do not show concerning data so far, but these are very limited. Currently, alternative treatments should be used for IBD during pregnancy.
Antimicrobial Oleogel Containing Sustainably Prepared Silver-Based Nanomaterials for Topical Application
Authors: Ambrogi Valeria , Nocchetti Morena , Pietrella Donatella , Quaglia Giulia , Di Michele Alessandro , Latterini Loredana
Published: December 2023

Oleogels containing silica–silver-based nanomaterials were prepared to be used as potential antimicrobial treatment for preventing and curing skin infections. Fumed silica was used as a bifunctional excipient able to offer support to silver-based nanoparticle growth and act as a gelling agent for oleogel formulation. First, silica–silver composites were prepared following a sustainable method by contact of fumed silica and silver nitrate in the presence of ethanol and successive UV irradiation. The composites were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), ATR FT-IR spectroscopy and UV-Vis spectrophotometry. The presence of 8–20 nm spherical nanoparticles, in addition to the silica aggregates and AgNO3 crystals, was detected. The composites showed good antimicrobial activity against the Gram-negative Pseudomonas aeruginosa and the Gram-positive bacteria Staphylococcus aureus and Staphylococcus epidermidis. Thus, they were formulated in an oleogel, obtained using fumed silica as a gelling agent. For comparison, oleogels containing AgNO3 were prepared according to two different formulative techniques. The silica–silver-based oleogels showed good antimicrobial activity and did not show cytotoxic effects for fibroblasts and keratinocytes.
Effects of Early-Childhood-Based Interventions Influencing Bones: A Systematic Review
Authors: Rico-González Markel , Martín-Moya Ricardo , Moreno-Villanueva Adrián
Published: December 2023

A healthy lifestyle from early childhood is a crucial factor that influences bone-related factors in adulthood. In this context, physical education or psychomotricity from early childhood is an important opportunity to face this problem. The present article aims to systematically summarize school-based interventions, evaluated through randomized controlled trial design, that influence the bones of children from early childhood. A systematic review of relevant articles was carried out using four main databases (PubMed, ProQuest Central (including 26 databases), Scopus, and Web of Sciences) until 12 November 2023. From a total of 42 studies initially found, 12 were included in the qualitative synthesis. In brief terms, from early childhood and during puberty, children’s bones are particularly responsive to exercise, making this an ideal time for interventions to maximize bone health. Therefore, incorporating physical activity into school curriculums is a strategic approach for enhancing bone health in children. Mainly, plyometric exercises can significantly enhance bone density and geometry. Nevertheless, collaboration among educators, healthcare professionals, and parents is key for designing and implementing these effective interventions.
A Back–Forward Approach-Based Efficiency Performance Analysis Model for Hybrid Electric Propulsion Ships Using the Holtrop–Mennen Method
Authors: Hong Soon Ho , Kim Dong Min , Kim Sun Je
Published: December 2023

Due to tightening regulations on exhaust emissions from ships, there is a growing need to develop electric or hybrid electric propulsion systems to replace conventional diesel-based ship power systems. The hybrid electric propulsion system is suitable for small and medium-sized vessels and its energy efficiency significantly depends on the arrangement of different power sources, power control strategies for energy sources, and energy storage system (ESS). Therefore, an analytical simulation to evaluate the energy efficiency of ships with their structure and control strategies is needed. In this study, a back–forward approach-based efficiency performance analysis model was developed using the Holtrop–Mennen resistance model to calculate ship resistance and power demand based on a given ship’s speed profiles. This model has the advantages of using easily obtainable ship speed profiles as the input and can be modularized for each power source and ESS, incorporating mechanical performance limitations, and allows for rapid analysis. The developed analytical model was applied to a hybrid electric propulsion system in a marine support vessel and its energy efficiency was evaluated by establishing rule-based power control strategies. As a result, the engine efficiency of the hybrid electric propulsion system increased from about 27% to 30% compared to the existing system, and the final effect of reducing fuel consumption by about 10% compared to the existing system was confirmed through the developed simulator. In the future, this analytical model could be utilized to derive the optimal layout of hybrid electric propulsion systems, and to formulate power control strategies.