bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of Muscle Activation Levels Between Healthy Individuals and Persons Who Have Undergone Anterior Cruciate Ligament Reconstruction During Different Phases of Weight-Bearing Exercises
Authors: Harput Gulcan , Howard Jennifer Sebert , Mattacola Carl
Published: October 2016

Study Design

Cross-sectional, controlled laboratory study.

Background

Quantification of muscular activation during different phases of functional activities is important to understand activation deficits in individuals who have undergone anterior cruciate ligament reconstruction (ACLR).

Objectives

To compare activation levels of the vastus medialis (VM), medial hamstrings (MH), and gluteus medius (GMed) muscles during the different phases of weight-bearing tasks between individuals who had undergone ACLR and healthy controls.

Methods

Surface electromyography was used to measure the activation levels of the VM, MH, and GMed muscles in 16 participants who had undergone ACLR (average time since surgery, 4 years) and 15 healthy participants during the reach and return phases of the Star Excursion Balance Test (SEBT) and the ascending and descending phases of a step-down task (SDT). Repeated-measures analyses of variance were performed to determine whether muscle activation levels differed between groups during different phases of the tasks.

Results

There were significant group-by-phase interactions for the GMed during both the SEBT and SDT. Gluteus medius activation was lower for the ACLR group during the return phase of the posteromedial direction of the SEBT compared to the control group (P = .03). During the SDT, GMed activation was higher for the ACLR group during the ascending phase than during the descending phase (P<.001), while the control group showed no difference between phases (P = .71).

Conclusion

Individuals who had undergone ACLR have similar VM and MH activation compared to healthy individuals during different phases of the SDT and SEBT. However, phase differences for GMed activity and decreased GMed activity relative to healthy individuals were observed among ACLR participants. J Orthop Sports Phys Ther 2016;46(11):984–992. Epub 11 Oct 2016. doi:10.2519/jospt.2016.5896
Synthesis and field-emission characteristics of SiC nanowire forest
Authors: Lee Dongju , Song Sung Ho
Published: October 2016

Silicon carbide nanowire forests were successfully synthesized via a vapor–liquid–solid process. The synthesized SiC nanowires had planar stacking faults perpendicular to the nanowire axis, diameters of 70 – 180 nm and lengths of tens to hundreds of micrometers, and grew along the [111] orientation. The SiC nanowire forest was characterized in a field emitter application and exhibited excellent field emission properties. Furthermore, we carried out in-depth investigations into the growth mechanism of the SiC nanowires through adjusting the growth conditions.
Reconstruction--Fiction--Transfer
Authors: Kaufmann Sebastian
Published: October 2016

Artistic practices in ethnological knowledge transfer can be found in the wellknown account of James Cook’s first voyage (1768–1771) by John Hawkesworth (Account of the Voyages […] in the Southern Hemisphere, 1773), which shows that such travel accounts are not only vehicles of knowledge transfer but also means of knowledge (re)construction, and at times this process of remolding knowledge extends to a rewriting that includes elements of fiction. Hence, the article will draw on the material assembled by Cook and Joseph Banks in their Endeavour Journals to identify in Hawkesworth’s examples of (ethno-aesthetic) knowledge construction and “invention.” A comparison of the diff erent types
of texts is rewarding not least because Hawkesworth’s account strove to present the new knowledge to a broader audience. An identification of Hawkesworth’s departures from his sources facilitates the reading of the act of knowledge transfer as a process of knowledge transformation.
The primary care provider (PCP)‐cancer specialist relationship: A systematic review and mixed‐methods meta‐synthesis
Authors: Dossett Lesly A. , Hudson Janella N. , Morris Arden M. , Lee M. Catherine , Roetzheim Richard G. , Fetters Michael D. , Quinn Gwendolyn P.
Published: October 2016

Although they are critical to models of coordinated care, the relationship and communication between primary care providers (PCPs) and cancer specialists throughout the cancer continuum are poorly understood. By using predefined search terms, the authors conducted a systematic review of the literature in 3 databases to examine the relationship and communication between PCPs and cancer specialists. Among 301 articles identified, 35 met all inclusion criteria and were reviewed in‐depth. Findings from qualitative, quantitative, and disaggregated mixed‐methods studies were integrated using meta‐synthesis. Six themes were identified and incorporated into a preliminary conceptual model of the PCP‐cancer specialist relationship: 1) poor and delayed communication between PCPs and cancer specialists, 2) cancer specialists' endorsement of a specialist‐based model of care, 3) PCPs' belief that they play an important role in the cancer continuum, 4) PCPs' willingness to participate in the cancer continuum, 5) cancer specialists' and PCPs' uncertainty regarding the PCP's oncology knowledge/experience, and 6) discrepancies between PCPs and cancer specialists regarding roles. These data indicate a pervasive need for improved communication, delineation, and coordination of responsibilities between PCPs and cancer specialists. Future interventions aimed at these deficiencies may improve patient and physician satisfaction and cancer care coordination. CA Cancer J Clin 2017;67:156–169. © 2016 American Cancer Society.
Assessing the Protective Quality of Wax Coatings on Bronze Sculptures Using Hydrogel Patches in Impedance Measurements
Authors: England Alice , Hosbein Kathryn , Price Capri , Wylder Morgan , Miller Kenna , Clare Tami
Published: October 2016

In this work, we used chemically cross-linked acrylamide-based hydrogel patches that have been specifically developed for use as solid electrolytes in Electrochemical Impedance Spectroscopy to measure the impedance of two waxed bronze sculptures at the Seattle Art Museum’s (SAM) Olympic Sculpture Park (OSP) and compare those results to laboratory test panels. We determined that the impedance response in the frequency range in which measurements may be taken (10 kHz to 1 MHz) is mostly capacitive and that a freshly applied wax coating should ideally be less than 1 nF·cm−2 for optimal protective performance.
On Goodput and Energy Measurements of Network Coding Schemes in the Raspberry Pi
Authors: Hernández Marcano Néstor , Sørensen Chres , Cabrera G. Juan , Wunderlich Simon , Lucani Daniel , Fitzek Frank
Published: October 2016

Given that next generation networks are expected to be populated by a large number of devices, there is a need for quick deployment and evaluation of alternative mechanisms to cope with the possible generated traffic in large-scale distributed data networks. In this sense, the Raspberry Pi has been a popular network node choice due to its reduced size, processing capabilities, low cost and its support by widely-used operating systems. For information transport, network coding is a new paradigm for fast and reliable data processing in networking and storage systems, which overcomes various limitations of state-of-the-art routing techniques. Therefore, in this work, we provide an in-depth performance evaluation of Random Linear Network Coding (RLNC)-based schemes for the Raspberry Pi Models 1 and 2, by showing the processing speed of the encoding and decoding operations and the corresponding energy consumption. Our results show that, in several scenarios, processing speeds of more than 80 Mbps in the Raspberry Pi Model 1 and 800 Mbps in the Raspberry Pi Model 2 are attainable. Moreover, we show that the processing energy per bit for network coding is below 1 nJ or even an order of magnitude less in these scenarios.
Combined Production and Conversion of Energy in an Urban Integrated System
Authors: Borelli Davide , Devia Francesco , Lo Cascio Ermanno , Schenone Corrado , Spoladore Alessandro
Published: October 2016

Within the framework of the European Combined Efficient Large Scale Integrated Urban Systems (CELSIUS) project, the Genoa demonstrator involves the insertion of a turbo expander (TE) to substitute the standard throttling process in a natural gas expansion station. In this way, the currently wasted mechanical energy will be recovered, while an internal combustion combined heat and power (CHP) unit will be used to meet the heating requirements of the gas before the expansion and to serve a small district heating network (DHN). Both TE and CHP are capable of delivering electric power (EP) up to 1 MW. In order to match the EP production vs demand is highly desirable to use the EP extra capacity for local EP final users, such as a nearby public school and a gas refueling station (RS). For limiting the school’s consumption of fossil fuel, it is possible to use the EP surplus generated by the demonstrator to feed a heat pump in parallel to the heating conventional system. With regard to the RS, the compressors are currently driven by electric motors, with a high-energy consumption. The integrated system gives the possibility of exploiting the surplus of electricity production and of recovering heat, which would be otherwise wasted, from the intercooling of compressed gas, thus powering the DHN through a preheating system. The result expected from this strategy is a relevant energy and emissions saving due to an integrated use of the electricity generated by the Genoese demonstrator for feeding the nearby school and RS.
Psychological Correlates of Self-Reported and Objectively Measured Physical Activity among Chinese Children—Psychological Correlates of PA
Authors: Wang Jing-Jing , Baranowski Tom , Lau Patrick , Chen Tzu-An , Zhang Shu-Ge
Published: October 2016

This study aimed to explore the associations among psychological correlates and physical activity (PA) in Chinese children and to further examine whether these associations varied by different PA measures. PA self-efficacy, motivation, and preference were reported in 449 8–13-year-old Chinese children (252 males). Moderate- to vigorous- intensity PA (MVPA) was measured by the Physical Activity Questionnaire for Older Children (PAQ-C) and with an ActiGraph GT3X accelerometer. Correlations and hierarchical regressions were performed to explore their associations. The study psychological variables were all positively related to PAQ-C and objective MVPA (r: 0.22–0.63). The associations with PAQ-C were all substantially stronger than those with accelerometry. Beyond the explained variance accounted for by demographics and social desirability, the addition of the psychological correlates accounted for 45% of the variance of the PAQ-C score, while only 13% for accelerometry-based MVPA. The associations of specific variables with the PAQ-C score (age, PA self-efficacy, autonomous motivation and preference) were somewhat different from those associated with objective MVPA (PA self-efficacy, autonomous motivation, and negatively associated with female gender). This study demonstrated the importance of self-efficacy and autonomous motivation in association with PA and indicated the difference in level of their associations with different PA measures.
Total Energy Expenditure in Obese Kuwaiti Primary School Children Assessed by the Doubly-Labeled Water Technique
Authors: Davidsson Lena , Al-Ghanim Jameela , Al-Ati Tareq , Al-Hamad Nawal , Al-Mutairi Anwar , Al-Olayan Lulwa , Preston Thomas
Published: October 2016

The aim of this pilot study was to assess body composition and total energy expenditure (TEE) in 35 obese 7–9 years old Kuwaiti children (18 girls and 17 boys). Total body water (TBW) and TEE were assessed by doubly-labeled water technique. TBW was derived from the intercept of the elimination rate of deuterium and TEE from the difference in elimination rates of 18O and deuterium. TBW was used to estimate fat-free mass (FFM), using hydration factors for different ages and gender. Fat mass (FM) was calculated as the difference between body weight and FFM. Body weight was not statistically different but TBW was significantly higher (p = 0.018) in boys (44.9% ± 3.3%) than girls (42.4% ± 3.0%), while girls had significantly higher estimated FM (45.2 ± 3.9 weight % versus 41.6% ± 4.3%; p = 0.014). TEE was significantly higher in boys (2395 ± 349 kcal/day) compared with girls (1978 ± 169 kcal/day); p = 0.001. Estimated physical activity level (PAL) was significantly higher in boys; 1.61 ± 0.167 versus 1.51 ± 0.870; p = 0.034. Our results provide the first dataset of TEE in 7–9 years old obese Kuwaiti children and highlight important gender differences to be considered during the development of school based interventions targeted to combat childhood obesity.
MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions
Authors: Catalanotto Caterina , Cogoni Carlo , Zardo Giuseppe
Published: October 2016

The finding that small non-coding RNAs (ncRNAs) are able to control gene expression in a sequence specific manner has had a massive impact on biology. Recent improvements in high throughput sequencing and computational prediction methods have allowed the discovery and classification of several types of ncRNAs. Based on their precursor structures, biogenesis pathways and modes of action, ncRNAs are classified as small interfering RNAs (siRNAs), microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs), endogenous small interfering RNAs (endo-siRNAs or esiRNAs), promoter associate RNAs (pRNAs), small nucleolar RNAs (snoRNAs) and sno-derived RNAs. Among these, miRNAs appear as important cytoplasmic regulators of gene expression. miRNAs act as post-transcriptional regulators of their messenger RNA (mRNA) targets via mRNA degradation and/or translational repression. However, it is becoming evident that miRNAs also have specific nuclear functions. Among these, the most studied and debated activity is the miRNA-guided transcriptional control of gene expression. Although available data detail quite precisely the effectors of this activity, the mechanisms by which miRNAs identify their gene targets to control transcription are still a matter of debate. Here, we focus on nuclear functions of miRNAs and on alternative mechanisms of target recognition, at the promoter lavel, by miRNAs in carrying out transcriptional gene silencing.
Rack1 Mediates the Interaction of P-Glycoprotein with Anxa2 and Regulates Migration and Invasion of Multidrug-Resistant Breast Cancer Cells
Authors: Yang Yi , Wu Na , Wang Zhiyong , Zhang Fei , Tian Ran , Ji Wei , Ren Xiubao , Niu Ruifang
Published: October 2016

The emergence of multidrug resistance is always associated with more rapid tumor recurrence and metastasis. P-glycoprotein (P-gp), which is a well-known multidrug-efflux transporter, confers enhanced invasion ability in drug-resistant cells. Previous studies have shown that P-gp probably exerts its tumor-promoting function via protein-protein interaction. These interactions were implicated in the activation of intracellular signal transduction. We previously showed that P-gp binds to Anxa2 and promotes the invasiveness of multidrug-resistant (MDR) breast cancer cells through regulation of Anxa2 phosphorylation. However, the accurate mechanism remains unclear. In the present study, a co-immunoprecipitation coupled with liquid chromatography tandem mass spectrometry-based interactomic approach was performed to screen P-gp binding proteins. We identified Rack1 as a novel P-gp binding protein. Knockdown of Rack1 significantly inhibited proliferation and invasion of MDR cancer cells. Mechanistic studies demonstrated that Rack1 functioned as a scaffold protein that mediated the binding of P-gp to Anxa2 and Src. We showed that Rack1 regulated P-gp activity, which was necessary for adriamycin-induced P-gp-mediated phosphorylation of Anxa2 and Erk1/2. Overall, the findings in this study augment novel insights to the understanding of the mechanism employed by P-gp for promoting migration and invasion of MDR cancer cells.
Erratum: Mangiatordi, G.F., et al. Human Aquaporin-4 and Molecular Modeling: Historical Perspective and View to the Future. Int. J. Mol. Sci. 2016, 17, 1119
Authors:   Editorial Office
Published: October 2016

The following changes have been made to the published paper[1].[...]
Drivers of Households’ Land-Use Decisions: A Critical Review of Micro-Level Studies in Tropical Regions
Authors: Hettig Elisabeth , Lay Jann , Sipangule Kacana
Published: October 2016

This paper reviews 91 recent empirical and theoretical studies that analyzed land-use change at the farm-household level. The review builds on a conceptual framework of land-use change drivers and conducts a meta-analysis. Results show that the conversion of forests into cultivated land or grassland, mainly used for agriculture or ranching, are most frequently analyzed. Only a small number of studies consider the transition of wetlands for agriculture and few cases deal with the conversion from agriculture into protected zones. Moreover, interactions between drivers add to the complexity of land-use change processes. These interrelationships are conditioned by institutions and policies. In particular, the market-oriented reforms adopted by many developing countries in the 1980s and 1990s seem to have had an important role in altering land use, while impacts of more recent policies need to be better explored. Many studies rely on small samples and face problems of internal validity. Despite these weaknesses, the literature points at micro-level economic growth, for example in income and capital endowments, as a strong catalyst of human induced land-use change. However, the review suggests that—across the different studies and cases—there is considerable heterogeneity in the relationship between these factors and land-use change.
Correction: Yan, X., et al. Study on Utilization of Carboxyl Group Decorated Carbon Nanotubes and Carbonation Reaction for Improving Strengths and Microstructures of Cement Paste. Nanomaterials 2016, 6, 153
Authors: Yan Xiantong , Cui Hongzhi , Qin Qinghua , Tang Waiching , Zhou Xiangming
Published: October 2016

The authors wish to make the following correction to this paper [1].[...]
Perception of the Professional Knowledge of and Education on the Medical Technology Products among the Pharmacists in the Baltic and Nordic Countries—A Cross-Sectional Exploratory Study
Authors: Volmer Daisy , Sokirskaja Aleksandra , Laaksonen Raisa , Vainio Kirsti , Sandler Niklas , Halvorsen Kjell , Kjome Reidun , Gizurarson Sveinbjörn , Muceniece Ruta , Maurina Baiba , Dauksiene Jurgita , Ruuben Lilian , Björnsdottir Ingunn , Ratassepp Tagne , Heinämäki Jyrki
Published: October 2016

With increased development of medical technology (MT), new challenges emerge related to education and training of pharmacists and other healthcare specialists. Currently, only a few universities in the EU promote MT education and research. Objectives: The aim of this study was to evaluate the current status, views on, and need for the education on MT for the pharmacy students and practicing pharmacists in the Baltic and Nordic countries. Methods: The representatives of higher education institutions and community/hospital pharmacists from six Baltic and Nordic countries participated in a qualitative cross-sectional exploratory internet-based study from May to October 2014. Results: Approximately two-third of the respondents considered professional knowledge about MT products important for pharmacists, but half of them had never participated in any MT courses. More practicing pharmacists than representatives of academia underlined the need for increased MT education for pharmacy students in the future. Conclusions: The pharmacists in the Baltic and Nordic countries consider the professional knowledge about MT as pertinent in their education and work. The limited number and status of MT courses available today, however, is a major concern among both pharmacy students and practicing pharmacists in these countries. In the future, increasing education combining theory and practice about MT products would be one possible solution to overcome this challenge.
Full On-Device Stay Points Detection in Smartphones for Location-Based Mobile Applications
Authors: Pérez-Torres Rafael , Torres-Huitzil César , Galeana-Zapién Hiram
Published: October 2016

The tracking of frequently visited places, also known as stay points, is a critical feature in location-aware mobile applications as a way to adapt the information and services provided to smartphones users according to their moving patterns. Location based applications usually employ the GPS receiver along with Wi-Fi hot-spots and cellular cell tower mechanisms for estimating user location. Typically, fine-grained GPS location data are collected by the smartphone and transferred to dedicated servers for trajectory analysis and stay points detection. Such Mobile Cloud Computing approach has been successfully employed for extending smartphone’s battery lifetime by exchanging computation costs, assuming that on-device stay points detection is prohibitive. In this article, we propose and validate the feasibility of having an alternative event-driven mechanism for stay points detection that is executed fully on-device, and that provides higher energy savings by avoiding communication costs. Our solution is encapsulated in a sensing middleware for Android smartphones, where a stream of GPS location updates is collected in the background, supporting duty cycling schemes, and incrementally analyzed following an event-driven paradigm for stay points detection. To evaluate the performance of the proposed middleware, real world experiments were conducted under different stress levels, validating its power efficiency when compared against a Mobile Cloud Computing oriented solution.
Development and Testing of a Two-UAV Communication Relay System
Authors: Li Boyang , Jiang Yifan , Sun Jingxuan , Cai Lingfeng , Wen Chih-Yung
Published: October 2016

In the development of beyond-line-of-sight (BLOS) Unmanned Aerial Vehicle (UAV) systems, communication between the UAVs and the ground control station (GCS) is of critical importance. The commonly used economical wireless modules are restricted by the short communication range and are easily blocked by obstacles. The use of a communication relay system provides a practical way to solve these problems, improving the performance of UAV communication in BLOS and cross-obstacle operations. In this study, a communication relay system, in which a quadrotor was used to relay radio communication for another quadrotor was developed and tested. First, the UAVs used as the airborne platform were constructed, and the hardware for the communication relay system was selected and built up. Second, a set of software programs and protocol for autonomous mission control, communication relay control, and ground control were developed. Finally, the system was fully integrated into the airborne platform and tested both indoor and in-flight. The Received Signal Strength Indication (RSSI) and noise value in two typical application scenarios were recorded. The test results demonstrated the ability of this system to extend the communication range and build communication over obstacles. This system also shows the feasibility to coordinate multiple UAVs’ communication with the same relay structure.
Performance Evaluation and Community Application of Low-Cost Sensors for Ozone and Nitrogen Dioxide
Authors: Duvall Rachelle , Long Russell , Beaver Melinda , Kronmiller Keith , Wheeler Michael , Szykman James
Published: October 2016

This study reports on the performance of electrochemical-based low-cost sensors and their use in a community application. CairClip sensors were collocated with federal reference and equivalent methods and operated in a network of sites by citizen scientists (community members) in Houston, Texas and Denver, Colorado, under the umbrella of the NASA-led DISCOVER-AQ Earth Venture Mission. Measurements were focused on ozone (O3) and nitrogen dioxide (NO2). The performance evaluation showed that the CairClip O3/NO2 sensor provided a consistent measurement response to that of reference monitors (r2 = 0.79 in Houston; r2 = 0.72 in Denver) whereas the CairClip NO2 sensor measurements showed no agreement to reference measurements. The CairClip O3/NO2 sensor data from the citizen science sites compared favorably to measurements at nearby reference monitoring sites. This study provides important information on data quality from low-cost sensor technologies and is one of few studies that reports sensor data collected directly by citizen scientists.
A Stepped Frequency Sweeping Method for Nonlinearity Measurement of Microresonators
Authors: Wei Yumiao , Dong Yonggui , Huang Xianxiang , Zhang Zhili
Published: October 2016

In order to measure the nonlinear features of micromechanical resonators, a free damped oscillation method based on stair-stepped frequency sinusoidal pulse excitation is investigated. In the vicinity of the resonant frequency, a frequency stepping sinusoidal pulse sequence is employed as the excitation signal. A set of free vibration response signals, containing different degrees of nonlinear dynamical characteristics, are obtained. The amplitude-frequency curves of the resonator are acquired from the forced vibration signals. Together with a singular spectrum analysis algorithm, the instantaneous amplitudes and instantaneous frequencies are extracted by a Hilbert transform from the free vibration signals. The calculated Backbone curves, and frequency response function (FRF) curves are distinct and can be used to characterize the nonlinear dynamics of the resonator. Taking a Duffing system as an example, numerical simulations are carried out for free vibration response signals in cases of different signal-to-noise ratios (SNRs). The results show that this method displays better anti-noise performance than FREEVIB. A vibrating ring microgyroscope is experimentally tested. The obtained Backbone and FRF curves agree with those obtained by the traditional frequency sweeping method. As a test technique, the proposed method can also be used to for experimentally testing the dynamic characteristics of other types of micromechanical resonators.
A Hybrid Spectral Clustering and Deep Neural Network Ensemble Algorithm for Intrusion Detection in Sensor Networks
Authors: Ma Tao , Wang Fen , Cheng Jianjun , Yu Yang , Chen Xiaoyun
Published: October 2016

The development of intrusion detection systems (IDS) that are adapted to allow routers and network defence systems to detect malicious network traffic disguised as network protocols or normal access is a critical challenge. This paper proposes a novel approach called SCDNN, which combines spectral clustering (SC) and deep neural network (DNN) algorithms. First, the dataset is divided into k subsets based on sample similarity using cluster centres, as in SC. Next, the distance between data points in a testing set and the training set is measured based on similarity features and is fed into the deep neural network algorithm for intrusion detection. Six KDD-Cup99 and NSL-KDD datasets and a sensor network dataset were employed to test the performance of the model. These experimental results indicate that the SCDNN classifier not only performs better than backpropagation neural network (BPNN), support vector machine (SVM), random forest (RF) and Bayes tree models in detection accuracy and the types of abnormal attacks found. It also provides an effective tool of study and analysis of intrusion detection in large networks.
The Non-Linear Effect of Chinese Financial Developments on Energy Supply Structures
Authors: Chai Jian , Xing Limin , Lu Quanying , Liang Ting , Lai Kin , Wang Shouyang
Published: October 2016

Currently, oversupply coal and coal-based power in China poses a great challenge to energy structure optimization and emissions reduction. The energy industry, however, is closely linked to the financial sector. In view of this, using a non-linear Panel Smooth Transition Regression (PSTR) model, this paper examines the threshold effects of financial developments on energy supply structures for 17 energy supply provinces in China observed over 2000–2014. The main results are: (1) The ratio of coal supply (LCSR) specification is seen to be a four-regime PSTR model with added value in the financial industry/GDP (LFIR) as the threshold variable. The LFIR and LCSR show a positive correlation, and the elastic coefficients change between 0.02 and ~0.085; the impact of financial institutions’ loan balance/GDP (LLAN) on LCSR takes on an inverse U-shaped curve: first positive, then negative, and again positive with the financial crisis in 2008 as the turning point; (2) The ratio of thermal power generation (LTPG) specification is seen to be a two-regime PSTR model with investment in the coal industry/GDP (LCIR) as the threshold variable. Results show that LFIR has a negative effect on LTPG, and the coefficients in the low regime tend to be 0.344%, then gradually decrease to 0.051% in the high regime. The influence of LLAN on the LTPG is positive before and negative after the financial crisis. The influence of the foreign direct investment GDP proportion (LFDI, the degree of financial openness) on the LCSR and LTPG both remain negative. Therefore, in the process of formulating energy conservation policies and adjusting energy-intensive industrial structures, the government should fully consider the effect of financial developments.
Stakeholder Deliberation on Developing Affordable Housing Strategies: Towards Inclusive and Sustainable Transit-Oriented Developments
Authors: Chava Jyothi , Newman Peter
Published: October 2016

Transit-oriented developments (TODs) are commanding high land and rental values due to improved accessibility and economic opportunities. Owing to the increase in land and rental values, the highly desirable TODs are gradually becoming inaccessible to the poor, creating social exclusion and housing inequities within the TODs. To address this consequence, the study proposes a three-level stakeholder deliberation framework (inform, involve, and collaborate) towards developing inclusive housing strategies for equitable and sustainable TODs. The framework is applied to the context of the Yeshwanthpur industrial area, Bengaluru, India. The first level of deliberation, ‘information’, foregrounds the need for affordable housing strategies for stakeholders. In the second level of deliberation, the stakeholders involved identify the major challenges in incorporating affordable housing into TODs. In the third level of deliberation, stakeholders collaborate to contemplate strategies to combat each challenge. The results show that mandatory inclusionary zoning, special-purpose planning vehicles, land banking entities, innovative financing tools, and local area level plans in collaboration with the community, emerged as potentially feasible strategies to create inclusive housing outcomes in the TOD case study area.
Characterization of Haptoglobin Isotype in Milk of Mastitis-Affected Cows
Authors: Upadhyaya Indu , Thanislass Jacob , Veerapandyan Anitha , Badami Sharanabasav , Antony Prabhakar
Published: October 2016

Haptoglobin is a major acute phase protein in bovines and reportedly increases in serum and milk whey during mastitis, highlighting its potential as a diagnostic biomarker. Since haptoglobin is known to undergo tissue specific glycosylation resulting in different isoforms, this study was undertaken to characterize the isoforms of haptoglobin. Milk whey fraction and serum obtained from animals with or without clinical mastitis in Puducherry, India, were subjected to SDS-PAGE followed by western blot and immuno-detection of haptoglobin protein. All subunits (β, α1 and α2) of haptoglobin protein were detected in serum sample obtained from clinical cases. However, only the β-subunit was detected in milk whey fraction obtained from the respective animals. Similar results were observed with milk whey fractions from subclinical cases indicating difference in isoform of haptoglobin detected in milk whey from serum. This was further supported by RT-PCR (Reverse Transcription Polymerase Chain Reaction) analysis of haptoglobin gene (Hp) confirming the tissue specific origin of haptoglobin.
Neural Stem Cell-Conditioned Medium Suppresses Inflammation and Promotes Spinal Cord Injury Recovery
Authors: Cheng Zhijian , Bosco Dale B. , Sun Li , Chen Xiaoming , Xu Yunsheng , Tai Wenjiao , Didier Ruth , Li Jinhua , Fan Jianqing , He Xijing , Ren Yi
Published: October 2016

Spinal cord injury (SCI) causes functional impairment as a result of the initial injury followed by secondary injury mechanism. SCI provokes an inflammatory response that causes secondary tissue damage and neurodegeneration. While the use of neural stem cell (NSC) engraftment to mitigate secondary injury has been of interest to many researchers, it still faces several limitations. As such, we investigated if NSC-conditioned medium (NSC-M) possesses therapeutic potential for the treatment of SCI. It has been proposed that many of the beneficial effects attributed to stem cell therapies are due to secreted factors. Utilizing primary cell culture and murine models of SCI, we determined that systemic treatment with NSC-M was able to significantly improve motor function and lesion healing. In addition, NSC-M demonstrated significant anti-inflammatory potential in vitro and in vivo, reducing inflammatory cytokine expression in both activated macrophages and injured spinal cord tissues. NSC-M was also able to reduce the expression of inducible nitric oxide synthase (iNOS) within the spleen of injured animals, indicating an ability to reduce systemic inflammation. Thus, we believe that NSC-M offers a possible alternative to direct stem cell engraftment for the treatment of SCI.
[ARTICLE WITHDRAWN] Upregulation of MicroRNA-935 Promotes the Malignant Behaviors of Pancreatic Carcinoma PANC-1 Cells via Targeting Inositol Polyphosphate 4-Phosphatase Type I Gene (INPP4A)
Authors: Wang Cuiyue , Feng Zhen , Jiang Kaitong , Zuo Xiuli
Published: October 2016

THIS ARTICLE WAS WITHDRAWN BY THE PUBLISHER IN NOVEMBER 2020
[ARTICLE WITHDRAWN] miR-1193 Suppresses Proliferation and Invasion of Human Breast Cancer Cells Through Directly Targeting IGF2BP2
Authors: Li Xianglei , Li Yanhua , Lu Hong
Published: October 2016

THIS ARTICLE WAS WITHDRAWN BY THE PUBLISHER IN NOVEMBER 2020
Diels–Alder reactions in confined spaces: the influence of catalyst structure and the nature of active sites for the retro-Diels–Alder reaction
Authors: Cantín Ángel , Gomez M Victoria , de la Hoz Antonio
Published: October 2016

Diels–Alder cycloaddition between cyclopentadiene and p-benzoquinone has been studied in the confined space of a pure silica zeolite Beta and the impact on reaction rate due to the concentration effect within the pore and diffusion limitations are discussed. Introduction of Lewis or Brønsted acid sites on the walls of the zeolite strongly increases the reaction rate. However, contrary to what occurs with mesoporous molecular sieves (MCM-41), Beta zeolite does not catalyse the retro-Diels–Alder reaction, resulting in a highly selective catalyst for the cycloaddition reaction.
Information médicale et pilotage des établissements de santé
Authors: Riou Christine , Fresson J. , Madelon G. , Valence A. , Lesquebault B. , Chatellier Gilles , Cuggia Marc , Quantin Catherine
Published: October 2016

Les bases médico-administratives constituent un enjeu pour le pilotage des établissements de santé. Des personnels administratifs sont susceptibles d’y avoir accès. Leur exploitation pose des questions relatives à la gouvernance et à la confidentialité. L’objectif de cet article est de faire un point sur les organisations mises en place. Un questionnaire à destination des médecins des Départements d’information médicale (DIM) a été établi. Il portait sur 5 thèmes : description de l’établissement, positionnement des assistants de gestion, demandeurs d’accès, accès à des données agrégées, accès à des données individuelles. L’analyse a porté sur 171 questionnaires. Les établissements sont majoritairement publics et de petite taille. Les assistants de gestion sont rattachés hiérarchiquement à une Direction dans 55 % des cas. Dans 66 % des établissements les contrôleurs de gestion formulent des demandes d’accès aux données médicales. Dans 85 % des établissements, des demandes portent sur des données agrégées et dans 62 % des établissements sur des données individuelles. Elles sont majoritairement traitées par le DIM et au cas par cas. Cependant dans 29 % des cas aucune procédure de validation des accès n’est mise en place. Un comité d’accès aux données n’est consulté que dans 10 établissements. On relève un accès à des données non anonymisées dans 45 établissements. Les données PMSI sont exploitées par des structures administratives sans qu’une politique d’accès et d’exploitation soit toujours établie. Les missions des différents partenaires devraient être mieux définies dans le respect de la confidentialité des données de santé. Le DIM a un rôle central dans l’analyse médico-économique de celles-ci.
La stratégie d’innovation ouverte de Sanofi
Authors: Labrouche Geoffroy , Kechidi Med
Published: October 2016

Cet article aborde une thématique clé du management stratégique – et plus particulièrement du management de l’innovation : les stratégies d’innovation ouverte. Nous abordons plus spécifiquement ces pratiques en tant que manifestation de la capacité cognitive et conative d’une organisation à établir avec succès des relations d’affaires avec d’autres acteurs de son environnement – ses capacités relationnelles. Ces dernières permettent à la firme de compléter sa base de ressources et de s’adapter à son environnement. Dans un premier temps, nous étudions spécifiquement le cas du secteur de l’industrie pharmaceutique. En particulier, nous explicitons les contraintes qui pèsent sur la R&D des laboratoires et firmes dédiées aux biotechnologies. Nous les mettons en relation avec le développement des stratégies d’innovation ouverte dans le secteur. Dans un deuxième temps, nous étudions plus précisément le cas de la stratégie de Sanofi. Nous verrons que les développements stratégiques récents du Groupe marquent clairement une réorientation de la R&D vers un modèle d’innovation ouverte.
Challenges of Fracture Management for Adults With Osteogenesis Imperfecta
Authors: Gil Joseph A. , DeFroda Steven F. , Sindhu Kunal , Cruz Aristides I. , Daniels Alan H.
Published: October 2016

Osteogenesis imperfecta is caused by qualitative or quantitative defects in type I collagen. Although often considered a disease with primarily pediatric manifestations, more than 25% of lifetime fractures are reported to occur in adulthood. General care of adults with osteogenesis imperfecta involves measures to preserve bone density, regular monitoring of hearing and dentition, and maintenance of muscle strength through physical therapy. Surgical stabilization of fractures in these patients can be challenging because of low bone mineral density, preexisting skeletal deformities, or obstruction by instrumentation from previous surgeries. Additionally, unique perioperative considerations exist when operatively managing fractures in patients with osteogenesis imperfecta. To date, there is little high-quality literature to help guide the optimal treatment of fractures in adult patients with osteogenesis imperfecta. [Orthopedics.2017; 40(1):e17–e22.]
Mental Health Issues in Foster Care
Authors: Lohr W. David , Jones V. Faye
Published: October 2016

Children in foster care have exceptional needs due to their histories of abuse, neglect, and increased exposure to violence. The rates of psychiatric symptoms and disorders, such as attention-deficit/hyperactivity disorder, posttraumatic stress disorder, and reactive attachment disorder, are much higher in children in foster care; furthermore, the rate of these children receiving psychotropic medications is 3 times that of children who are not in foster care. Pediatricians, in their role of providing a medical home, play a central role in safeguarding the physical and mental health of these children. By taking a trauma-informed approach to understanding the unique needs and gaps in their health care, pediatricians can improve the mental health and maximize outcome for children in foster care.

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Pediatr Ann
. 2016;45(10):e342–e348.]
Pediatric Bipolar Disorder
Authors: Lee Terry
Published: October 2016

The diagnosis of bipolar disorder (BD) in youth is confusing and controversial. Controversy notwithstanding, youth diagnosed with BD have high behavioral health needs and are at elevated risk for problematic long-term psychosocial functioning and complex psychiatric medication regimens. Pediatricians and other primary care providers (PCPs) can play an important role in the assessment and treatment of youth diagnosed with BD and the recently created and also controversial diagnosis of disruptive mood dysregulation disorder (DMDD). This article provides information on the definitions, background, and presentation of pediatric bipolar disorder (PBD), how to differentiate PBD from other psychiatric disorders, effective psychiatric and psychosocial interventions for PBD, potential roles for PCPs, and what is known about DMDD.

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Pediatr Ann.
2016;45(10):e362–e366.]
Characterization of the properties of perlite geopolymer pastes
Authors: Tsaousi G. M. , Douni I. , Panias D.
Published: October 2016

This paper deals with the characterization of perlite-based geopolymer pastes, using fine perlite as raw material. The present study examined the effects of the main synthesis parameters such as perlite to activator ratio, NaOH concentration, the addition of soluble silica to the activator, and curing temperatureon the setting time, the stability in an aquatic environment, the viscosity of the paste, and the compressive strength of the solidified geopolymers. The results showed that these inorganic polymer pastes are non-Newtonian shear thinning fluids that achieve low viscosities at high shear stresses. The optimum synthesis conditions for the geopolymer pastes proved to be a) a low initial NaOH concentration in the alkaline phase (2–5 M) and b) a solid to liquid ratio of 1.2–1.4 g/mL. If very fast setting is necessary, the pastes should be prepared with a soluble silica-doped alkaline activating phase and cured at high temperatures around 90 °C.
Impact of Minocycline on Extracellular Matrix Metalloproteinase Inducer, a Factor Implicated in Multiple Sclerosis Immunopathogenesis
Authors: Hahn Jennifer N. , Kaushik Deepak K. , Mishra Manoj K. , Wang Jianxiong , Silva Claudia , Yong V. Wee
Published: October 2016

Extracellular matrix metalloproteinase inducer (EMMPRIN, CD147) is a transmembrane glycoprotein that is upregulated on leukocytes in active lesions in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Administration of anti-EMMPRIN Abs reduces the severity of EAE. Minocycline is a tetracycline antibiotic with immune-modulatory properties that decreases the severity of EAE; it was recently found to attenuate the conversion from a first demyelinating event to clinically definite MS in a phase III trial. We investigated whether and how minocycline affects the expression of EMMPRIN on T cells in culture and in mice afflicted with EAE. EMMPRIN expression in cultures of mouse splenocytes or human PBMCs was elevated upon polyclonal T cell activation, and this was reduced by minocycline correspondent with decreased P-Akt levels. An established MS medication, IFN-β, also diminished EMMPRIN levels on human cells whereas this was not readily observed for fingolimod or monomethylfumarate. In EAE-afflicted mice, minocycline treatment significantly reduced EMMPRIN levels on splenic lymphocytes at the presymptomatic (day 7) phase, and prevented the development of disease. Day 7 spleen transcripts from minocycline-treated EAE mice had a significantly lower MMP-9/TIMP-1 ratio, and significantly lower MCT-1 and CD98 levels, factors associated with EMMPRIN function. Day 16 (peak clinical severity) CNS samples from EAE mice had prominent representation of inflammatory perivascular cuffs, inflammatory molecules and EMMPRIN, and these were abrogated by minocycline. Overall, minocycline attenuated the activation-induced elevation of EMMPRIN on T cells in culture and in EAE mice, correspondent with reduced immune function and EAE CNS pathology.
Residual Isocyanates in Medical Devices and Products: A Qualitative and Quantitative Assessment
Authors: Franklin Gillian , Harari Homero , Ahsan Samavi , Bello Dhimiter , Sterling David A. , Nedrelow Jonathan , Raynaud Scott , Biswas Swati , Liu Youcheng
Published: October 2016

We conducted a pilot qualitative and quantitative assessment of residual isocyanates and their potential initial exposures in neonates, as little is known about their contact effect. After a neonatal intensive care unit (NICU) stockroom inventory, polyurethane (PU) and PU foam (PUF) devices and products were qualitatively evaluated for residual isocyanates using Surface SWYPE™. Those containing isocyanates were quantitatively tested for methylene diphenyl diisocyanate (MDI) species, using UPLC-UV-MS/MS method. Ten of 37 products and devices tested, indicated both free and bound residual surface isocyanates; PU/PUF pieces contained aromatic isocyanates; one product contained aliphatic isocyanates. Overall, quantified mean MDI concentrations were low (4,4‘-MDI = 0.52 to 140.1 pg/mg) and (2,4‘-MDI = 0.01 to 4.48 pg/mg). The 4,4‘-MDI species had the highest measured concentration (280 pg/mg). Commonly used medical devices/products contain low, but measurable concentrations of residual isocyanates. Quantifying other isocyanate species and neonatal skin exposure to isocyanates from these devices and products requires further investigation.