bluuebunny/crossref_metadata_2025 huggingface dataset:
Neuroplasticity and Content of Structural Elements in the Axoplasm of the Trigeminal Nerve During the Eruption of Permanent Teeth in Humans
Authors: Chuchkova N. N. , Polyakova O. L. , Smetanina M. V. , Pazinenko K. A. , Chuchkov V. M.
Published: January 2025

The aim of the presented study was to identify the features of the quantitative formation of axoplasmic organelles with a primary analysis of the components of the axonal cytoskeleton (microtubules and neurofilaments) of myelinated and non-myelinated nerve fibers in the dental pulp during the eruption of permanent teeth in humans. Material and methods. The neurovascular bundle of dental pulp was studied in children aged 5, 10 and 14 years. On ultramicrographs of pulp sections at a magnification of ×40000, the diameters of myelin and non-myelin conductors were measured; per 1 µm2 of axoplasm of nerve conductors, the density of axoplasmic organelles, the number of microtubules and neurofilaments were calculated. The reliability of differences between groups was assessed using multivariate analysis of variance (MANOVA), the significance of average values was assessed using the Tukey test, correlation analysis was carried out using the Pearson criterion. Results. The process of eruption of permanent teeth was accompanied by a gradual increase in the number of organelles per unit cross-sectional area of the nerve, regardless of its characteristics (myelinated or nonmyelinated fiber type). The highest density of organelles was observed in large-diameter fibers of both myelinated and non-myelinated conductors throughout the indicated segment of ontogenetic development. The presence of myelin in the nerve sheath correlates positively with microtubule saturation in fibers of large (r=0.267, p=0.001) and small (r=0.314, p=0.000) diameters, and negatively in fibers with medium diameter (r=-0.246, p=0.002). The proportion of neurofilaments represented among the axoplasmic organelles of the neuroplasm as a whole was especially high in myelinated and unmyelinated nerve fibers of small diameter, averaging up to 70%. The presence of the myelin sheath and fiber diameter are not associated with neurofilament density with the exception of medium-diameter fibers (r=0.195, p=0.001). Conclusion. The process of eruption of permanent teeth is accompanied by an increase in the number of organelles, cytoskeletal elements in the axoplasm of nerve fibers innervating the dental pulp, providing the morphological substrate of neuroplasticity, which must be taken into account, for example, in the process of dental implantation and dental prosthetics.
Clinical Anatomy of the Maxilla
Authors: Kabak S. L. , Mel'nichenko Yu. M. , Pil'chuk A. V.
Published: January 2025

The upper jaw is the most important structure of the middle third of the face. It is of great functional and aesthetic importance, and is also a clinically critical area in which a variety of surgical interventions are performed, such as the installation of dental implants, cyst removal, and endodontic dental treatment. To avoid iatrogenic complications of these manipulations (bleeding and/or neurological disorders), detailed knowledge of maxillary anatomy is required. This review, based on modern literature data and our own observations, outlines the clinical anatomy of the upper jaw with a description of the features of its morphology, identified using cone beam computed tomography, a modern technology for visualizing the bone structures of the maxillofacial region used in clinical practice. A description of a number of structures, such as the accessory infraorbital foramina, canalis sinuosus, alveolo-antral artery, nasopalatine (incisive) canal and maxillary sinus septa, is absent in human anatomy textbooks for students and is not detailed in Russian-language medical journals. The article presents radiographic images of these structures, their linear dimensions, frequency of occurrence in the population, and provides classifications of individual variants of intraosseous canals. The practical significance of each of these anatomical variations is discussed. All images used in the article are original and have not been published previously.
Polonia – National Allegory as a Place of Memory to 19th Century Polish Painting
Authors: Ute Mann Katharina
Published: January 2025

The article first of all discusses the ways in which the artists – after the Polish state had lost its sovereignty – were engaged in bringing back the former grandness of the nation and country, and the way they awoke the state rebirth. The task was hindered by the annexationists’ policy, which – especially after the January Uprising – introduced intensive Russification or Germanisation by banning the use of Polish language in schools.
Polonia, as an allegory of the enslaved nation, is present not only in Jan Matejko’s works. Thanks to complexity of the symbolic contents and various pictorial instances in different paintings this allegory implies on us a careful look at the compound and multi-layered mechanisms of creation which the artists reached out for in order to bring about the desired effects. In their works they employed this amazing figure as the centre of national identification, which was capable of producing deep impression on the audience and allowed the people to build permanent, collective, national memory. This process along with the artists’ operations were best seen in extremely opposite approaches to Polonia as the Dead Polonia and the Crowned Polonia. These images moved the viewers in many different ways acting on them according to the artists’ intention. The author of the article is convinced that the artists not only cherished the memory and built the national awareness, but also directed or even manipulated both of them.
The figure of Polonia is not deprived of her European context, which the author has taken into consideration together with analogous personifications, to name but Marianne or Germania. With this background, and by contrast, Polonia’s individuality has been revealed. Polish Messianism applied on its banner Adam Mickiewicz’s phrase “Poland the Christ of Nations” adding to the figure of Polonia a mark of martyrological beauty, and ascribing to it the roles of a redeemer and a leader of the enslaved nations on their road to political and social liberation. This martyrological aspect echoed most and endowed Polonia with a character of “a place of memory”.
KEANEKARAGAMAN JENIS TUMBUHAN BERKHASIAT OBAT DI KTH MEKAR SARI TAHURA WAN ABDUL RACHMAN
Authors: Andriyani Della Eka , Bintoro Afif , Asmarahman Ceng , Indriyanto Indriyanto
Published: January 2025

Tahura Wan Abdul Rachman adalah kawasan konservasi alam yang terletak di Provinsi Lampung. Salah satu tumbuhan yang ada di Tahura Wan Abdul Rachman adalah tumbuhan obat, yaitu tanaman yang memiliki kandungan senyawa yang bermanfaat dan berkhasiat untuk mencegah, mengurangi, atau menyembuhkan penyakit. Penelitian ini bertujuan untuk mengukur tingkat keanekaragaman tumbuhan obat. Penelitian ini dilakukan di lahan KTH Mekar Sari Tahura Wan Abdul Rachman, dengan metode plot ganda. Plot yang digunakan berukuran 2 m x 2 m, 5 m x 5 m, 10 m x 10 m dan 20 m x 20 m. Hasil penelitian menunjukkan 11 jenis tumbuhan obat tingkat pohon dewasa, 10 jenis pada tingkat tiang, 10 jenis pada tingkat pancang dan 12 jenis pada tingkat semai. Terdapat 20 jenis tumbuhan obat dengan indeks keanekaragaman sebesar 0,87 dan masuk dalam kategori rendah.
KERAGAMAN JENIS PAKAN DAN STATUS HABITAT BEKANTAN (Nasalis larvatus) DI EKOSISTEM RIPARIAN SUNGAI KATINGAN, KALIMANTAN TENGAH
Authors: Ariyani Helma , Fithria Abdi , Soendjoto Mochamad Arief
Published: January 2025

Bekantan merupakan satwa endemik Kalimantan yang statusnya hampir punah. Salah satu cara menjaga kelestarian satwa ini dengan mempertahankan habitat yang memiliki potensi sebagai pakan bekantan. Penelitian ini bertujuan untuk mengidentifikasi jenis sumber pakan bekantan, menganalisis keragaman jenis pohon habitat bekantan, dan menganalisis status habitat bekantan di ekosistem riparian sungai Katingan, Kalimantan Tengah. Penelitian ini dilaksanakan dengan metode accidental sampling untuk pengambilan data pohon pakan, pengambilan data vegetasi dilakukan dengan metode jalur. Hasil yang diperoleh dari penelitian ini yaitu (1) Pohon pakan bekantan di peroleh sebanyak 13 jenis pohon, presentasi terbesar bekantan adalah memakan daun sebesar 38% dan family yang terbanyak dimanfaatkan bekantan untuk makan adalah Myrtaceae sebesar 22%, (2) keragaman jenis vegetasi habitat bekantan di sungai Katingan pada tingkat tiang didapatkan H’ sebesar 3,14 sedangkan pada tingkat pohon didapatkan H’ sebesar 2,82 yang artinya keanekaragaman pada tingkat tiang dikategorikan tinggi dan vegetasi pohon dikategorikan sedang, (3) status habitat bekantan di hutan riparian di luar kawasan konservasi Taman Nasional Sebangau dengan tipe habitat penggunaan lain, dan tidak mendukung terhadap konservasi.
DETEKSI CACAT PADA CARBON FIBER REINFORCED POLYMER BERDASARKAN KOEFISIEN KORELASI PEARSON DARI SINYAL ECHO ULTRASONIK
Authors: Yusuf Giri Wijaya  , Suprijanto Suprijanto , Nugroho Afid , Hijazi Rhakamerta , Adhika Damar Rastri
Published: January 2025

Carbon fiber reinforced polymer (CFRP) adalah material komposit yang sering digunakan dalam industri penerbangan, otomotif, dan kelautan karena kekuatannya yang tinggi dan beratnya yang ringan. Namun, keandalan CFRP dapat terganggu oleh cacat internal yang terjadi selama proses manufaktur atau penggunaan. Penelitian ini bertujuan untuk mendeteksi adanya cacat pada CFRP berdasarkan koefisien korelasi Pearson dari sinyal echo ultrasonik. Metode ini menggunakan gelombang ultrasonik untuk mengidentifikasi cacat berdasarkan perubahan pola sinyal. Sinyal referensi diperoleh dengan merata-ratakan sinyal dari beberapa lokasi bebas cacat. Perubahan pola sinyal terhadap sinyal referensi dikuantifikasi menggunakan koefisien korelasi Pearson untuk mengklasifikasikan daerah bebas cacat dan yang memiliki cacat. Sampel uji berupa plat tipis CFRP dengan cacat buatan dari material teflon berbentuk lingkaran dengan jari-jari 15 mm yang diletakkan pada dua kedalaman berbeda. Hasil penelitian menunjukkan bahwa koefisien korelasi Pearson efektif membedakan antara area bebas cacat dan yang memiliki cacat. Area bebas cacat menunjukkan korelasi dalam rentang 0,97 sampai 1, sementara area dengan cacat menunjukkan korelasi rendah dalam rentang 0 sampai 0,36.
SISTEM UJI TAK RUSAK BERBASIS ULTRASONIK UNTUK KONTROL KUALITAS PADA FABRIKASI BATA TIMBAL
Authors: Hijazi Rhakamerta , Suprijanto  , Haryanto Freddy , Haerudin Ahmad , Wijayaa Yusuf Giri , Sulistyo Jos Budi
Published: January 2025

BATAN memiliki wewenang dalam meningkatkan kualitas produksi bata timbal yang masih difabrikasi secara konvensional. Oleh karena itu, dikembangkan sebuah sistem uji tak rusak ini yang terdiri dari transduser Partial Immerse Technique yang digunakan agar dapat mengkompensasi sudut pemindaian tetap tegak lurus karena permukaan sisi atas bata timbal yang tidak rata, papan un0rick yang digunakan karena fleksibilitas dan kemampuannya yang baik dalam membuat pulsa listrik tegangan tinggi, dan frekuensi sampling yang tinggi, dan sebuah laptop. Hasil yang didapatkan adalah optimasi parameter ultrasonik berupa frekuensi transduser 500 KHz dengan panjang pulsa 0.5 Î¼s. Selain itu dilakukan pengujian pada 3 kasus. Bata timbal standar digunakan sebagai referensi memiliki cepat rambat 2.156 m/s. Bata timbal dengan cacat buatan memiliki hasil estimasi cacat titik pertama berada pada 23,32 mm dengan error 16,62 %, estimasi lokasi cacat pada titik kedua adalah 25,1 mm dengan error 0,44 %, estimasi lokasi cacat titik ketiga adalah 36,17 mm dengan error 9,57 %, dan estimasi lokasi cacat titik keempat adalah 9,38 mm dengan error 6,2 %. Kasus ketiga adalah bata timbal dengan cacat alami memiliki hasil estimasi lokasi cacat 26.77 mm dengan error bernilai 1,08 %.
INVESTIGASI SIFAT MEKANIK MODEL BIODEGRADABLE STENT BERBASIS BAHAN PLLA
Authors: Hi. Abbas Muhammad Fadly , B Sukiman , Rais Sandi , Asyriati Latif Lita , Al Fajrin Syarif , Sakinah Munim Yulinda , Rajak Sahdar
Published: January 2025

Penyakit kardiovaskular merupakan penyebab kematian tertinggi di dunia, dengan penyakit terkait penyempitan pembuluh darah menjadi penyebab utama kematian di Indonesia. Salah satu solusi untuk menangani penyempitan pembuluh darah adalah penggunaan stent, salah satunya adalah biodegradable polymer stent yang terbuat dari poly L-lactic acid (PLLA). Stent yang diteliti dalam penelitian ini memiliki desain batik (BT) dengan strut searah (S><), kombinasi struktur open cell dan close cell. Penelitian ini menggunakan metode analisis desain dengan bantuan perangkat lunak Abaqus student melalui finite element method (FEM). Data dikumpulkan dengan mensimulasikan pemberian momen pada setiap kombinasi desain stent pada konfigurasi crimped dan expanded, dengan variasi ketebalan stent yaitu 120 µm, 130 µm, dan 140 µm. Hasil penelitian menunjukkan bahwa pada konfigurasi crimped, stent dengan ketebalan 130 µm menghasilkan nilai curvature index tertinggi, yang menunjukkan fleksibilitas terbaik. Sementara itu, pada konfigurasi expanded, stent dengan ketebalan 120 µm memberikan hasil terbaik untuk fleksibilitas. Penelitian ini berkontribusi signifikan terhadap pengembangan stent biodegradabel yang lebih fleksibel dan optimal, dengan implikasi praktis dalam meningkatkan desain stent untuk mengurangi komplikasi pasca-implantasi dan meningkatkan hasil klinis bagi pasien dengan penyakit kardiovaskular.
Apprentissage par projet en FabLab pour des étudiants en géographie à l’Université de Brest
Authors: Ruault Riwalenn , Letortu Pauline
Published: January 2025

Ce retour d’expérience présente deux expériences pédagogiques menées dans le cadre du module de climatologie en licence de géographie à l'Université de Brest. En s'appuyant sur une pédagogie par projet et l'utilisation d'un FabLab, ces expériences visent à favoriser un apprentissage en profondeur des concepts fondamentaux de climatologie chez les étudiants. Les projets proposés, ancrés dans des problématiques liées au changement climatique, permettent de développer des compétences variées (techniques, communicationnelles, etc.) tout en stimulant la motivation et l'engagement des étudiants. Par ailleurs, la plus-value est également pour l’équipe enseignante avec des changements de posture et un rôle d’expertise disciplinaire. Cette approche expérientielle ouvre ainsi des perspectives pour une meilleure articulation entre recherche, formation et ingénierie pédagogique.
Exploring how graft length shapes root system architecture and morphology in grapevine rootstocks
Authors: Larrey Mathieu , Tandonnet Jean-Pascal , Saint Cast Clément , Cookson Sarah Jane , Vivin Philippe
Published: January 2025

The success of grafting and the sustained growth of newly grafted grapevines depend on the ability of hardwood cuttings taken from parent plants to rapidly initiate new adventitious roots (ARs) and to establish a functional, well-distributed root system in the soil. There is a paucity of literature on the plasticity and diversity of grapevine root systems due to the difficulty of phenotyping the hidden part of the plant. This study aimed to investigate whether varying rootstock cutting length (8, 20, 30, and 50 cm), and as a consequence the initial pool of reserves, influences root system architecture (RSA) and root morphological traits of two scion/rootstock combinations, Vitis riparia cv. Riparia Gloire de Montpellier (RGM) and the V. berlandieri x V. rupestris hybrid cv. 1103 Paulsen (1103P), grafted with scions of V. vinifera cv. Cabernet-Sauvignon. Two experiments were carried out: one in 2022 involving 240 plants grown in pots, and another in 2023 with 32 plants grown in rhizotrons. The latter allowed for non-invasive, time-lapse 2D imaging of early root system development providing quantitative data on adventitious and lateral roots, including their number, length, diameter and branching patterns. The length of the rootstock significantly influenced the recovery and early-stage growth of the grafted grapevines, impacting both shoot and root development. Longer rootstocks led to accelerated emergence of ARs and increased their number, irrespective of rootstock genotype, as well as promoted greater total root system length and mass. The maximum number of ARs was positively correlated with graft fresh mass, suggesting a link between initial reserves and root development. While CS/1103P produced more ARs and had longer first-order roots compared to CS/RGM, both combinations produced similar total root biomass. However, they displayed distinct RSA patterns: 1103P ARs grew at narrower angles, while RGM roots spread more horizontally. These differences reflect varied strategies for soil exploration and resource utilization. Although certain root morphological traits remained unaffected by rootstock length, RGM showed greater plasticity in response to reduced initial reserves, as indicated by a smaller apical diameter with shorter grafts.Overall, this study emphasizes the significance of considering rootstock length and RSA in viticultural practices. The insights gathered here contribute to a deeper understanding of the mechanisms governing root development in grafted grapevines, thereby informing strategies to enhance grafting techniques and optimize grapevine cultivation.
Pengembangan Instrumen Soal Berorientasi Praktek Keterampilan Pemecahan Masalah Materi Laju Reaksi
Authors: Minatus Wahyuni , Drastisianti Apriliani , Mulyanti Sri
Published: January 2025

The question instrument on the reaction rate material contains two competencies, namely understanding concepts and counting to help students who can increase the enthusiasm of students' learning activities. The method used in this study refers to the 4D development model proposed by Thiagarajan (1974). The 4D development model has 4 stages, namely define, design, develop, and disseminate. In this study, it was shown that the question instrument developed had a good interpretation so that it was able to make students understand more about the concept of material on the rate of reaction.
Strategi dan Media Scaffolding pada Pembelajaran Berbasis Inkuiri: Sebuah Kajian Literatur
Authors: Purtadi Sukisman , Suyanta Suyanta , Rohaeti Eli
Published: January 2025

This literature review aims to analyze the forms of scaffolding strategies and their learning media used in inquiry-based learning (PBI). Scaffolding is a type of guidance given to students in the learning process with many types and strategies that are adapted to their learning objectives. the right scaffolding strategy will improve learning outcomes. Therefore, it is necessary to do a literature review to be able to determine the scaffolding strategy to be used. The study was conducted on 43 research articles that had been published from 2015 to 2022. These articles were selected based on the systematic steps of determining study questions, selecting publications, filtering articles based on keywords. Furthermore, the selected articles were reviewed with the aid of Atlasti.9. The results of this study concluded that the question prompt is a common strategy in guiding students to inquiry. Some of the media used to help students are worksheets and computer-assisted media.
Elektroplating Eksperimen sebagai Penguatan Konsep Elektrokimia
Authors: Asworo Yuliana Dwi
Published: January 2025

The Covid-19 pandemic has changed various community activities including in the world of education, where students and teachers are required to be able to adapt in life and be able to master essential material in every subject. Electrochemistry is a branch of chemistry that studies the relationship between chemical reactions and electrical energy, namely the transfer of electrons that occur. The material about electroplating is part of electrochemistry, namely about electrolytic cells, where students must know the reactions that occur at the negative electrode (cathode) and positive electrode (anode) as well as the solution used for gilding and the object to be plated. The complexity of the material in electrochemistry makes the teacher think hard how to make learning activities in class fun and memorable so that the learning material is remembered by students. One way to make learning activities in class come alive is to do practicum. In this study the authors carried out a different practicum from the previous year, namely gilding(electroplating)the metalbrought by the students and presenting the results in video form. The research subjects were 36 students of class XII IPA1 at MAN 10 Jakarta. Before practicum activities, the teacher gives Student Activity Sheets (SAS) so that students understand the steps of practicum activities to be carried out. In the implementation of practicum activities, it begins with the Pretest, practicum electroplating and making Chemistry wallmagazines and ends with the Posttest. At the end of the assignment, students make a video presentation of the results of the metal plating they have done by showing chemistry wall magazines andpractical explanations alsoanswers thequestions from the SAS. The final result obtained is that students enjoy learning activities and get increased results from pre to pot test from the average score 65 becomes 93,06, and have directed communication skills in video presentation based on the wall magazines they have made related to the concept of electrolytic cells.
Medialized vs. Lateralized Reverse Total Shoulder Arthroplasty for Proximal Humerus Fractures
Authors: Holt Kara E. , Bindi Victoria E. , Buchanan Timothy R. , Reddy Akshay R. , Tishad Abtahi , Desai Persis , Hones Keegan M. , Wright Thomas W. , Schoch Bradley S. , King Joseph J. , Hao Kevin A.
Published: January 2025

Background:

Reverse shoulder arthroplasty (RSA) is increasingly used in the treatment of proximal humerus fractures (PHFs) with reliable clinical improvement. Lateralized RSA implants have conferred superior outcomes compared with the original Grammont design in patients with nontraumatic indications. However, in the setting of a PHF, lateralized components can place increased tension across the tuberosity fracture site and potentially compromise tuberosity healing and outcomes. This systematic review and meta-analysis sought to determine the effect of implant design on clinical outcomes after RSA for PHFs.

Methods:

A systematic review was performed per Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed/MEDLINE, EMBASE, Web of Science, and Cochrane were queried for clinical studies on RSA performed for PHFs that reported implant manufacturer details. Our primary outcomes included postoperative external rotation (ER), forward elevation (FE), abduction, Constant score, rate of greater tuberosity (GT) healing, and the incidence of complications compared between medialized vs. lateralized global implant design.

Results:

Globally lateralized RSA cohorts (478 RSAs total with cumulative lateral offset achieved through humeral or glenoid lateralization or both humeral and glenoid lateralization) were found to have a greater mean postoperative Constant score compared with globally medialized (medialized glenoid and medialized humerus) RSA cohorts with 1,494 total medialized RSAs (66 vs. 59, p = 0.006), but there was no significant difference regarding mean postoperative ER (30° vs. 22°, p = 0.078), FE (117° vs. 119°, p = 0.708), or abduction (103° vs. 107°, p = 0.377). On meta-regression, neither implant design nor tuberosity status significantly influenced postoperative ER, FE, abduction, or Constant score on meta-regression independent of mean follow-up and age at surgery. The rate of GT healing was greater in lateralized compared with medialized RSAs (88% vs. 72%, p < 0.001). On meta-regression, medialized RSA design was associated with a 73% lower odds of GT healing (odds ratio = 0.27, 95% confidence interval = 0.11-0.68, p = 0.007) independent of mean follow-up and age at surgery.

Conclusion:

Lateralized RSA implants conferred no significant functional benefit over medialized implants when used in patients with PHFs.

Level of Evidence:

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Injury-Associated Anemia in Orthopaedic Trauma: A Comprehensive Review
Authors: Landers Andrea L. , Peterson Danielle F. , McKibben Natasha S. , Hutchison Catherine E. , Trapalis Talia , DeKeyser Graham J. , Friess Darin M. , Working Zachary M.
Published: January 2025

» Anemia is a common comorbidity in orthopaedic trauma patients with important clinical consequences, significantly negatively affecting a patient's course following orthopaedic trauma.

» Anemia remains relatively understudied in the orthopaedic trauma population with a large amount of current literature focused solely on geriatric hip fracture patients.

» Greater investigation into alternatives to blood transfusions such as iron therapy or cell salvaging for treatment of anemia in the orthopaedic trauma population is needed.
Knee Pain Is Not Always the Knee
Authors: Lygrisse Katherine A. , Mont Michael A. , Scuderi Giles R.
Published: January 2025

» Lumbar spine pathology is a known cause of referred pain to the lower extremities and should be investigated as a possible source of knee pain, especially with patients in their sixth decade.

» While primary knee pathology is common, spinal pathology should always be considered in older patients presenting with knee pain, especially in atraumatic cases where knee imaging does not correlate with complaints or examination findings.

» Lumbar (L) 3-4 pathology is most commonly affected in referred knee pain, with the 2 most common pathologies being spinal stenosis and disc herniation.

» If knee radiographs do not demonstrate major pathology that correlates with a patient's history and examination, a thorough spine examination should then be performed with attention paid to patellar tendon reflex, quadriceps muscle strength, and any loss of sensation, as these can be hallmarks of L3-4 pathology.
REGULATORY AND SUPERVISORY TECHNOLOGY RESEARCH: A BIBLIOMETRIC ANALYSIS
Authors: Fachsandy Faturrahman
Published: January 2025

This bibliometric study examines articles on Supervisory Technology (SupTech) and Regulatory Technology (RegTech). The investigation’s main focus was on author trends and keywords. The data was carefully examined from the sources indexed on Dimension.ai, where ‘SupTech’ and ‘RegTech’ were the search terms. A bibliometric map was derived using VOSviewer for bibliometric analysis and a descriptive statistical method. VOSviewer software was used to analyse the development trends of publications related to RegTech and Supertech. In recent years, there has been a sharp increase in the number of papers published on RegTech and SupTech. Various journals have tackled the subject, two of the best being “Fintech and RegTech: Impact on Regulators and Banks” by Ioannis Anagnostopoulos and “The Role of Big Data, Machine Learning, and AI in Assessing Risks: A Regulatory Perspective” by Scott W. Bauguess. The most frequently used terms include regulation, supervision, compliance, finance, and technology. Furthermore, over the past ten years, Douglas W. Arner and Simone Di Castri have authored the most articles of any authors. Challenge and Study are two of this theme’s most commonly cited keywords. Digitalisation is critical today and presents a challenge for practitioners and researchers. Academics working in RegTech and SupTech can find relevant information in this study, which gives an overview of keyword trends and the most popular scholars on the subject.
ADVANCING FUTURISTIC DIGITAL BANKING: STRATEGIC ENHANCEMENT AND A ROADMAP FOR EXCELLENCE
Authors: Pratama Kristianus Jimy
Published: January 2025

This research aims to rectify misconceptions surrounding banking digitalisation and conduct an in-depth analysis of Bank Indonesia and the Financial Services Authority’s (OJK) policies concerning developing and enhancing the banking sector’s digitalisation. Additionally, this study is designed to formulate a strategic roadmap for developing banking sector digitalisation, accompanied by risk mitigation processes. The fundamental misconception identified herein pertains to the limited understanding of banking digitalisation as merely transitioning from conventional to digital services. This narrow perspective, still embraced by regulatory authorities, adversely impacts national banking industry stakeholders. Employing a normative legal research methodology through an extensive literature review, our findings reveal a prevailing tendency towards structural collaboration in policy formulation rather than embracing synergistic approaches. This research underscores the urgency of formulating visionary and flexible policies in banking digitalisation. Based on the findings, this study seeks to build the framework for policy formulation by regulation authorities in conducting further studies regarding the direction of policies for developing and strengthening banking sector digitalisation.
COMPARATIVE ANALYSIS OF CBDC AND TAX LAW ENFORCEMENT IN SELECTED COUNTRIES
Authors: Ramadhani Ressita , Farisy Zakka , Puteri Dina Silvia
Published: January 2025

This study explores the prospective Central Bank Digital Currency (CBDC) transactions whilst implementing the Automatic Exchange of Information (AEOI) procedures as part of tax law enforcement in Indonesia. The study seeks to address the challenges and opportunities associated with AEOI within a CBDC framework, considering their potential impact on financial transparency, data privacy, and regulatory compliance. Through normative research, comprehensively reviewing relevant literature and policy analysis, the study identifies best practices from other countries, including ASEAN, East Asia, Oceania, The Bahamas, and Sweden, and it aims to develop recommendations for designing an efficient and secure AEOI framework for CBDC transactions in Indonesia. The findings of this study are derived from lessons learnt from selected countries regarding AEOI practices: Australia, Brunei Darussalam, China, Japan, South Korea, Malaysia, New Zealand, and Singapore. Additionally, Sweden and the Bahamas provide aspirational benchmarks for CBDC implementation while simultaneously implementing AEOI. Recommendations are also generated to improve Indonesia’s CBDC and AEOI implementation progress.
Plan de Negocios para la producción y comercialización de bebidas saludables de tarwi con pulpa de frutas de la amazonía peruana en Lima Moderna
Authors:   , Guerra Yvala Pamela Viviana , Pacheco Paniura Diego Sebastian , Palma Rebollar Francesca Gabriela , Rivera Lobo Jerry Andres , Santiago Mendoza Judith Yajayra
Published: January 2025

Este negocio tiene como objetivo producir bebidas saludables a base de tarwi, una leguminosa andina que es rica en proteínas, fibra y otros nutrientes vitales. La pulpa y tarwi se combinan para producir una bebida nutritiva y natural. El tarwi con pulpa de frutas de cocona, el aguaje y el maracuyá son combinaciones muy conocidas que ofrecen a los clientes una variedad de opciones.
Este proyecto nació en respuesta al aumento de la demanda de productos naturales y funcionales que promuevan una alimentación balanceada y beneficiosa para la salud en el mercado de Lima Moderna.
El mercado de bebidas saludables está creciendo debido a las preferencias de los posibles consumidores hacia opciones más naturales y saludables. La combinación de tarwi, que es rico en proteínas, fibra y ácidos grasos esenciales, con frutas locales ofrece una propuesta única que no solo satisface las necesidades nutricionales, sino que también introduce un nuevo producto con valor agregado en el mercado.
Este modelo de negocio se basa en la producción local y sostenible, utilizando tarwi de pequeños agricultores andinos y frutas de proveedores. Las bebidas se distribuirán en tiendas naturistas, supermercados y canales de venta online, centrándose en clientes que buscan alternativas saludables y nutritivas. También hay planes para implementar un sistema de reciclaje de envases para aumentar la sostenibilidad del consumidor y la conciencia ambiental.
Correlation functions and characteristic lengthscales in flat band superconductors
Authors: Thumin Maxime , Bouzerar Georges
Published: January 2025

The possibility of an unconventional form of high temperature superconductivity in flat band (FB) material does not cease to challenge our understanding of the physics in correlated systems. Here, we calculate the normal and anomalous one-particle correlation functions in various one and two dimensional FB systems and systematically extract the characteristic lengthscales. When the Fermi energy is located in the FB, it is found that the coherence length (\xiξ) is of the order of the lattice spacing and weakly sensitive to the strength of the electron-electron interaction. Recently, it has been argued that in FB compounds \xiξ could be decomposed into a conventional part of BCS type (\xi_{BCS}ξBCS) and a geometric contribution which characterises the FB eigenstates, the quantum metric (\langle g \rangle⟨g⟩). However, by calculating the coherence length in two possible ways, our calculations show that \xi ≠ \sqrt{\langle g \rangle.}ξ≠⟨g⟩. This may suggest that the link between QM and coherence length is more complex, and leaves us with the open question: what is the appropriate definition of the coherence length in flat-band systems?
Urban system interactions during flood events: a system dynamics modeling approach
Authors: Peiris Mutu Tantrige Osada Vishvajith
Published: January 2025

Floods cause significant damage in cities due to their intensity, frequency, and vulnerability, which are driven by complex internal and external factors. Dynamic behavior of urban response during a flood event is difficult to measure due to urban systems’ complexity and non-linear behavior. This study simulates the flood response dynamics of people, inundated waters, and financial expenditure during a flood event to visualize the dynamics of urban flood events using Colombo City, Sri Lanka, as a case study. Sensitivity analysis was conducted for pumping infrastructure and flood relief expenditure to view the variation of flood damage using Monte Carlo simulation. Results revealed that pumping units and the initial flood relief budget significantly impact the flood recovery of inundated areas. The results were validated using flood water pumping statistics and hydrology models conducted for historical flood events. The system dynamics framework is useful for combining multiple parameters in the flood modeling process to understand the complex relationships between population, flood inundation, and financial relief programs. This framework can be expanded to quantify the effects of mitigation and adaptation strategies in flood-vulnerable cities to optimize the decision-making process.
Germinação e vigor de sementes de Mimosa caesalpiniifolia Benth. sob estresse hídrico e salino
Authors:   , Sousa Eduardo Chaves de
Published: January 2025

Mimosa caesalpiniifolia Benth., conhecida por sabiá no Nordeste brasileiro, é uma espécie florestal nativa da Caatinga e pertencente à família Fabaceae. Recentemente foi incluída na lista de espécies vulneráveis em função de sua utilização como madeira, lenha e carvão vegetal. Sementes de espécies que se desenvolvem em solos de regiões áridas e semiáridas, a exemplo de M. caesalpiniifolia, comumente encontram condições inadequadas para a germinação, como solos afetados pela deficiência hídrica e abundância de solos salinos. Assim, objetivou-se avaliar o efeito dos estresses hídrico e salino na germinação e vigor de sementes de três lotes de M. caesalpiniifolia provenientes de matrizes localizadas nos municípios de Luziania – GO (Lote 1), Vazante – MG (Lote 2) e Montanhas – RN (Lote 3). Na simulação da restrição hídrica foram utilizados dois agentes osmóticos, manitol e polietilenoglicol 6000 (PEG 6000), ajustados para os potenciais osmóticos de 0; -0,2; -0,4; -0,6 e -0,8 MPa. Para simular o estresse salino, foram utilizadas soluções de NaCl, nas condutividades elétricas de 0,0; 5,0; 10,0; 15,0; 20,0; 25,0; 30,0 dS m-1. Foram avaliados: germinação, índice de velocidade de germinação, comprimento da parte aérea e da raiz e massa seca da parte aérea e da raiz das plântulas. O delineamento experimental foi inteiramente casualizado, com quatro repetições de 25 sementes para cada tratamento. Os resultados demonstraram que o estresse hídrico induzido por manitol não influenciou a germinação e o comprimento da raiz das plântulas de sabiá, reduziu o IVG e o comprimento e massa seca da parte aérea das plântulas, e aumentou a massa seca da raiz das plântulas. A restrição hídrica simulada com PEG, por sua vez, se mostrou mais crítica, reduzindo a porcentagem e a velocidade de germinação, o comprimento da parte aérea e da raiz, além da massa seca da parte aérea e da raiz das plântulas. Os três lotes responderam de maneira semelhante ao estresse hídrico, porém o Lote 3, com sementes provenientes de Montanhas – RN, foi menos vigoroso que os demais. A salinidade reduziu a germinação e o vigor das sementes de M. caesalpiniifolia, diminuindo os parâmetros avaliados nas condutividades elétricas mais elevadas (25,0 e 30,0 dS m-1), e afetando de maneira mais expressiva, o IVG e o comprimento da parte aérea das plântulas. O Lote 2 se mostrou mais tolerante ao estresse salino.
ALS: A Silent Slayer of Motor Neurons. Traditional Chinese Herbal Medicine as an Effective Therapy
Authors: Rai Anjali , Shukla Shivang , Gupta Ramesh Kumar , Mishra Anuradha
Published: January 2025

Amyotrophic Lateral Sclerosis (ALS), is a progressive neurodegenerative disease characterized by
motor symptoms, and cognitive impairment. The complexity in treating ALS arises from genetic and environmental
factors, contributing to the gradual decline of lower and upper motor neurons. The anticipated
pharmaceutical market valuation for ALS is projected to reach $1,038.94 million by 2032. This projection underscores
the escalating impact of ALS on global healthcare systems. ALS prevalence is expected to surge to
376,674 cases by 2040. In 2022, India ranked among the top 3 Asian-Pacific nations, while North America
dominated the global ALS market. Ongoing investigations explore the potential of neuroprotective drugs like
riluzole and edaravone in ALS treatment. Recently approved drugs, Relyvrio (sodium phenylbutyrate and taurursodiol)
and Tofersen (Qalsody) have completed the trials, and others are currently undergoing extensive
clinical trials. Continuous research and exploration of therapeutic avenues, including gene therapy and neuroprotective
treatments, are imperative to address the challenges posed by ALS and other neurodegenerative
diseases. Traditional Chinese Medicine (TCM) approaches and clinical trials are being explored for treating
ALS symptoms, targeting neuroinflammation, oxidative damage, and muscle weakness, showcasing the potential
benefits of integrating traditional and modern approaches in ALS management.
The Outcomes of Pediatric, Adolescent, and Young Adult Oncology Patients With Non-neutropenic Fever: A Scoping Review of the Literature
Authors: Wagner Annabelle , Akarsu Yeliz , Remke Marc , Schoendorf Dominik , Huebner Johannes , Lehrnbecher Thomas , Hufnagel Markus , Bochennek Konrad , Simon Arne
Published: January 2025

Background:

There are established and well-followed guidelines for pediatric oncology
patients who have neutropenic fever. However, there are no explicit criteria for this patient
group, and over 50% of pediatric oncology patients with fever do not present with neutropenia.

Objective:

In this scoping review, we have explored the outcomes of non-neutropenic fever in pediatric,
adolescent, and young adult patients with cancer-directed treatment. The results of this
scoping review should assist in the creation of a guideline for the management of non-neutropenic
fever in this group of patients.

Method:

Multiple electronic databases and reference lists were searched (PubMed, MEDLINE
CENTRAL, and Google (first 100 results only)). Included are retrospective and prospective cohort
studies on the management and outcome of pediatric oncology patients with non-neutropenic
fever that have been published after the year 2000.

Results:

Seventeen studies with a total of 10.845 fever episodes were included, that address the
treatment and outcome of patients with non-neutropenic fever. The rate of bacteremia was 1.6 -
14.4% (mean 5.8%). The mortality rate was low due to non-bacterial causes. Across different
studies, proposed risk factors for bacteremia were higher temperature, prolonged fever over 72
hours, ill-appearing patients, chills, hypotension, leukocytosis, infancy, and the presence of a Broivac/
Hickman catheter. Limitations to this study are the risk of bias, and potential incomplete identification
of relevant studies pertinent to the research questions asked.

Conclusion:

Due to significant heterogeneity, the published data so far are not sufficient to propose
evidence-based guidelines for pediatric oncology patients with non-neutropenic fever.
Prospective, multicenter registries based on uniform definitions are needed. No funding was received
for this manuscript.
Next-Generation Biomaterials and Tissue Engineering: Innovations, Challenges, and Future Directions
Authors: Aljabali Alaa A. A. , Alwattar Jana K. , Obeid Mohammad A. , Tambuwala Murtaza M.
Published: January 2025

Biomaterials and tissue engineering have undergone significant advances, particularly
with the integration of nanoscience technology. Recent progress in nanostructured scaffolds
and nanoparticle-based delivery systems has provided novel opportunities for tissue regeneration.
However, the key challenges remain and must be addressed. These include the optimization
of the long-term stability of nanoengineered constructs and addressing the concerns
regarding nanotoxicity. Fine-tuned mechanical properties enable the adoption of vehicle-based
targeted approaches to drug and gene delivery. However, much remains to be learned regarding
the interactions between nanomaterials and tissues. Comprehensive safety assessments and
standardized toxicity evaluations are essential for clinical translation. These emerging technologies
combine the three-dimensional bioprinting of induced pluripotent stem cells with nanomaterials
and new pathways for personalized medicine. Nanoengineered smart materials and
biosensors have the potential to enable real-time monitoring of engineered tissues, which can
pave the way for unparalleled advances in personalized therapies, particularly for chronic diseases.
The bioactivity of nanomaterials offers new avenues for tissue regeneration. This review
explores the status, successes, challenges, and future directions of biomaterials and tissue engineering,
with a specific focus on nanoscience applications. Key areas for future research include
nano-bio-interfaces, in situ tissue remodeling, and biofabrication techniques. These insights
can guide researchers to navigate the rapidly evolving landscape of nanoscience, related
biomaterials, and tissue engineering. The integration of nanomaterials into tissue engineering
is an emerging and advanced field that has significant implications for regenerative medicine.
A Three-agent Regimen for Triple Negative Breast Cancer Treatment
Authors: Wang Shaojun , Huang Congxiu , Zhu Ying , Wang Min , Wang Wei , Liu Caixia , Su Wuyun
Published: January 2025

Background:

Triple-negative breast cancer (TNBC) has a poor prognosis with current
treatment options. Novel therapeutic strategies are urgently needed to enhance treatment outcomes
for TNBC.

Objective:

This study evaluated the efficacy of a three-agent regimen compared to existing treatment
regimens in a TNBC mouse model, and elucidated its potential mechanisms of action.

Methods:

The TNBC xenograft tumor mouse model was established using a 4T1 cell line in female
BALB/c mice. Mice were treated with the three-agent regimen and other comparative treatments.
Tumor volume was monitored to assess the anti-tumor effects. Biochemical and pathological
evaluations were conducted to examine the impact of the regimen on anti-tumor immunity, anti-
tumor angiogenesis, and tumor cell apoptosis.

Results:

The three-agent regimen consisting of SIN+BEV+PAB demonstrated significant anti-tumor
efficacy compared to controls, PAB alone, SIN+PAB, and BEV+PAB groups from day 9 of
drug administration. The superior anti-tumor effect of SIN+BEV+PAB was primarily attributed to
enhanced anti-tumor immunity, evidenced by increased percentages of CD4+ and CD8+ T cells,
elevated IFN-γ levels, and decreased percentages of Tregs, reduced levels of TGF-β, IL-6, and
IL-10. Additionally, the regimen showed potent anti-angiogenic effects by reducing VEGF expression
and micro vessel density (MVD). Furthermore, it promoted tumor cell apoptosis through upregulation
of BAX and cleaved caspase3, while downregulating Bcl2.

Conclusion:

These findings suggest that the novel three-agent combination of SIN+BEV+PAB
may prove beneficial in improving treatment outcomes for patients with TNBC. The development
of this regimen, which may be eligible for patent protection, could facilitate its introduction as a
new therapeutic option for advanced TNBC in clinical practice.
Pharmacological and Dietary Significance of Indian Spices: A Mini-
Review
Authors: Gupta Priyanka , Iqbal Asif , Kayes Imrul , Pal Radheshyam , Ashique Sumel
Published: January 2025

Indian spices, which provide food taste, color, and scent, also have several medicinal
benefits. The therapeutic uses of these plants were described in ancient Indian writings of Ayurveda,
an Indian medical system. Numerous active chemicals with pharmacological effects have been
shown to exist in these spices, according to recent scientific studies. Experimental and clinical research
has also confirmed the medicinal effectiveness of these distinct spices for certain pharmacological
activities. Modern pharmacological and experimental approaches corroborate the therapeutic
benefits long attributed to Indian spices, giving their traditional therapeutic use a scientific basis.
Various parts of plants are used as spices to prepare food recipes. Still, this review considered that
these particular plants have some important roles and also mentioned their chemistry, pharmacological
activity, and traditional use as folk medicine.
Why is it Important to Assess and Treat Alexithymia in the Cardiologic Field? An Overview of the Literature
Authors: Sancassiani Federica , Montisci Roberta , Meloni Luigi , Nardi Antonio Egidio , Carta Mauro Giovanni
Published: January 2025

Background:

Alexithymia has been found to be associated with several somatic illnesses, such as cardiovascular, indicating that it might be a risk factor for early death in the long-term course of post-myocardial infarction. From the cardiology perspective, the aim was to collect current evidence about the relationship between alexithymia and somatic illness.

Methods:

The literature was synthesized and summarized in a narrative format. The literature search was carried out in PubMed. Pertinent studies published in the last 50 years written in English were included and organized by three main topics (“The relation between alexithymia and somatic illness from the cardiology perspective”; “How do assess alexithymia?”; “Treating alexithymia”) to be discussed.

Results:

High alexithymia is a dimensional trait that affects around 10% of the general population and up to 55% of people with essential hypertension. Also, the link between alexithymia and cardiovascular activity has been pointed out. There are several validated tools to assess alexithymia, as well as treatment options.

Conclusion:

Knowledge about the main features of alexithymia, as well as its assessment and treatment, can promote a multifactorial approach to the primary, secondary, and tertiary prevention of cardiac diseases.