bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Motivasi dan Disiplin Kerja Terhadap Kinerja Karyawan
Authors: Ananda Filea , Agung Wahyu Handaru  , Christian Wiradendi Wolor
Published: April 2023

The aims of this research are to find out the description of motivation, work discipline and performance employees, to find out the effect of motivation on the performance employees and to find out the effect of work discipline on the performance employees. This research was conducted on 56 employees of PT Garuda Muthia Shandy. The data collection technique used a survey method through the distribution of questionnaires and processed using SPSS version 25 software. The results obtained from the regression analysis show that there is a positive and significant influence between motivation and work discipline on employee performance. The research model of motivation and work discipline has a significant simultaneous effect on employee performance and significance value obtained less than 0.05. Practical implications, the company needs to maintain and increase motivation and give rewards to employees who have good performance. The company needs to improve and pay more attention to employees so that employees remain disciplined. Employees already have a fairly good quality of work, but the company still needs to improve and confirm the existing regulations so that employee performance will increase.

 

Tujuan penelitian ini adalah mengetahui deskripsi dari motivasi, disiplin kerja dan kinerja karyawan, mengetahui pengaruh dari motivasi terhadap kinerja karyawan dan mengetahui pengaruh dari disiplin kerja terhadap kinerja karyawan. Penelitian ini dilakukan kepada 56 karyawan PT Garuda Muthia Shandy. Teknik pengumpulan data menggunakan metode survei melalui penyebaran kuesioner dan diolah menggunakan perangkat lunak SPSS versi 25. Hasil yang didapat dari analisis regresi menunjukkan terdapat pengaruh positif dan signifikan antara motivasi dan disiplin kerja terhadap kinerja karyawan. Model penelitian motivasi dan disiplin kerja berpengaruh signifikan secara simultan terhadap kinerja karyawan dan nilai signifikansi yang didapat lebih kecil dari 0,05. Implikasi Praktis, perusahaan perlu mempertahankan dan meningkatkan motivasi dan memberikan penghargaan kepada karyawan yang memiliki kinerja baik. Perusahaan perlu meningkatkan dan lebih memperhatikan karyawan agar tetap disiplin. Karyawan sudah memiliki kualitas hasil pekerjaan yang cukup baik, namun perusahaan tetap perlu meningkatkan dan menegaskan peraturan-peraturan yang sudah berlaku agar kinerja karyawan semakin meningkat.
Analisis Faktor-faktor yang Mempengaruhi Niat Investasi Agen Reksa Dana Online pada Investor Potensial
Authors: Pandu Irawan Abdullah  , Umi Widyastuti  , Muhammad Fawaiq
Published: April 2023

Penelitian ini bertujuan untuk mengidentifikasi faktor-faktor yang mempengaruhi niat investasi investor potensial untuk berinvestasi melalui agen reksa dana online. Variabel yang diukur adalah niat investasi, pengetahuan investasi, risiko yang dirasakan, dan kontrol perilaku yang dirasakan. Metode penelitian ini adalah penelitian kuantitatif dengan populasi masyarakat Indonesia dan teknik sampel menggunakan non-probability sampling dengan teknik pengambilan purposive sampling. Kriteria sampel adalah investor potensial yang belum berinvestasi di agen reksa dana online dan memiliki gelar D3. Penelitian dilakukan dengan menyebarkan kuesioner secara daring dengan sampel 161 responden. Teknik analisis data menggunakan software Smart PLS dan pengujian dalam penelitian ini meliputi uji validitas, uji reliabilitas, uji hipotesis, dan uji model. Hasil penelitian ini membuktikan bahwa pengetahuan investasi dan kontrol perilaku yang dirasakan memiliki pengaruh yang signifikan terhadap niat investasi. Sedangkan risiko yang dirasakan tidak berpengaruh secara signifikan terhadap niat investasi. Serta adanya pengaruh yang signifikan antara pengetahuan investasi dan kontrol perilaku yang dirasakan.
Pengaruh Literasi Keuangan, Norma Subjektif, Dan Sikap Terhadap Niat Menabung Mahasiswa Pendidikan Di Jabodetabek
Authors: Pangestika Chandra Dewi  , Umi Widyastuti  , Muhammad Yusuf
Published: April 2023

Saving is often done by someone to prepare funds or money needs in the future according to the wishes, hopes and needs of the person. This study aims to examine the effect of financial literacy, subjective norms, and attitudes on the saving intention of education students in Jabodetabek. This research uses quantitative research. The number of samples used in this study were 209 respondents, and the sampling was done through an online questionnaire, namely Google Form. Data were processed using SPSS and Amos, SPSS for explanatory factor analysis and AMOS for confirmatory factor analysis. Financial literacy does not affect students' intention to save, the test results show that the model used for this study is rejected. Financial literacy does not affect the attitude to save, the test results show that the model used for this study is rejected. Subjective norms affect the attitude to save, the test results show that the model used for this study is accepted. Subjective norms do not affect students' intention to save, the test results show that the model used for this study is rejected. Attitudes to save affect the intention to save students, the test results show that the model used for this study is accepted..

Keyword: Financial Literacy, Subjective Norms, Attitudes To Save, Intention To Save, Education Students in Jabodetabek.

Menabung seringkali dilakukan seseorang untuk mempersiapkan dana atau uang kebutuhan di waktu yang akan datang sesuai keinginan, harapan dan kebutuhan orang tersebut. Penelitian ini bertujuan untuk menguji pengaruh literasi keuangan, norma subjektif, dan sikap terhadap niat menabung mahasiswa pendidikan di Jabodetabek. Penelitian ini menggunakan jenis penelitian kuantitatif. Jumlah sampel yang digunakan dalam penelitian ini sebanyak 209 responden, dan pengambilan sampel dilakukan melalui kuesioner online yaitu Google Form. Data diolah menggunakan SPSS dan Amos, SPSS untuk explanatory factor analysis dan AMOS untuk comfirmatory factor analysis. Literasi keuangan tidak mempengaruhi niat untuk menabung mahasiswa, hasil pengujian menunjukkan bahwa model yang digunakan untuk penelitian ini ditolak. Literasi keuangan tidak mempengaruhi sikap untuk menabung, hasil pengujian menunjukkan bahwa model yang digunakan untuk penelitian ini ditolak. Norma subjektif mempengaruhi sikap untuk menabung, hasil pengujian menunjukkan bahwa model yang digunakan untuk penelitian ini diterima. Norma subjektif tidak mempengaruhi niat untuk menabung mahasiswa, hasil pengujian menunjukkan bahwa model yang digunakan untuk penelitian ini ditolak. Sikap untuk menabung mempengaruhi niat untuk menabung mahasiswa, hasil pengujian menunjukkan bahwa model yang digunakan untuk penelitian ini diterima.

Kata kunci: Literasi Keuangan, Norma Subjektif, Sikap Untuk Menabung, Niat Untuk Menabung, Mahasiswa Pendidikan di Jabodetabek.
Buku Ajar Mata Kuliah Pengantar Menejemen Ekonomi Teknik
Authors:   Universitas Muhammadiyah Sidoarjo, Wisaksono Arief
Published: April 2023

Dalam kehidupan kita sehari-hari, kita semua menghasilkan pemikiran yang sangat tajam dalam kaitannya dengan masa depan. Entah itu perubahan besar atau kecil, keyakinan yang kita pegang itulah yang membentuk kehidupan kita sehari- hari. Misalnya, membeli barang baru secara curang akan meningkatkan keamanan finansial Anda karena Anda terus-menerus bekerja dan akan mengurangi jumlah uang yang Anda miliki saat itu. Selain itu, membeli kendaraan baru dan diberi tahu bahwa paket pembayaran seluler memberi pelanggan akses ke inventaris baru di toko, tetapi hal itu akan mengakibatkan hilangnya uang yang tersedia secara signifikan karena adanya pembayaran bunga bulanan.
Buku Ajar Strategi Belajar Mengajar Di Sekolah Dasar
Authors:   Universitas Muhammadiyah Sidoarjo, Tirtoni Feri , Kurniawan Machful Indra
Published: April 2023

Puji Syukur kami ucapkan kehadirat Allah Subhanahu WaTa’ala dan shalawat serta salam salam kepada junjungan kami Nabi Muhammad Shallallahu ‘Alaihi Wasallam. Pendidikan adalah hal yang utama bagi para insan manusia agar mereka dapat menjadi generasi penerus bangsa yang berintelektual dan mampu bersaing untuk memajukan bangsa Indonesia. Buku Strategi Belajar Mengajar di SD ini sangat dibutuhkan mahasiswa S1 PGSD dan akademisi dunia pendidikan, sebab Latar belakang dari penyusunan buku ini adalah sebuah pemikiran bahwa kemampuan dalam aplikasi model dan media pembelajaran adalah sebuah hal yang kelak akan menjadi sebuah pionir utama dalam upaya mensukseskan KBM dan tentunya
Buoyant Flow of H2 Vs. CO2 in Storage Aquifers: Implications to Geological Screening
Authors: Ren Bo , Jensen Jerry , Duncan Ian , Lake Larry
Published: April 2023

Hydrogen will play an important role in the quest to decarbonize the world’s economy by substituting fossil fuels. In addition to the development of hydrogen generation technologies, the energy industry will need to increase hydrogen storage capacity to facilitate the development of a robust hydrogen economy. The required hydrogen storage capacity will be much larger than current hydrogen and natural gas storage capacities. There are several geological storage options for hydrogen that include depleted hydrocarbon fields and aquifers, where more research is needed until the feasibility of storing hydrogen at scale is proved. Here, we investigate the buoyant flow of H2 (as a working gas) vs. CO2 (as a cushion gas) separately in a representative storage aquifer. Buoyant flow can affect the maximum storage, capillary trapping, likelihood of leakage, and deliverability of aquifer-stored hydrogen.

After building a 2D geological reservoir model initially filled with saline water, we ran numerical simulations to determine how hydrogen placed at the bottom of an aquifer might rise through the water column. The Leverett j-function is used to generate heterogeneous capillary entry pressure fields that correlate with porosity and permeability fields. Hydrogen viscosities were based on the Jossi et al. correlation, and the density was modeled using the Peng-Robinson equation of state. We then simulated several scenarios to assess flow during short- (annually) and long- (several years) term storage. For comparison purposes, we also ran CO2 storage simulations using the same geological model but with CO2-brine-rock properties collected from the literature.

For a representative storage aquifer (323 K, 15.7 MPa, and mean permeability of 200 md), significant fingering occurred as the hydrogen rose through the saline water column. The hydrogen experienced more buoyant flow and created flow paths with increased fingering when compared with CO2. Individual hydrogen fingers are thinner than the CO2 fingers in the simulations, and the tips of hydrogen finger fronts propagated upward roughly twice as fast as the CO2 front for a typical set of heterogeneity indicators (Dykstra-Parson’s coefficient Vdp = 0.80, and dimensionless autocorrelation length λDx = 2).

The implications of buoyant flow for hydrogen in saline aquifers include an increased threat of leakage, more residual trapping of hydrogen, and, therefore, the need to focus more on the heterogeneity and lateral correlation behavior of the repository. If hydrogen penetrates the caprock of an aquifer, it will leak faster than CO2 and generate more vertical flow pathways. We identify possible depositional environments for clastic aquifers that would offer suitable characteristics for storage.
The Effect of Knowledge Brokering on Cardiac Nurses' Empathy With Their Patients: A Field Randomized Controlled Trial
Authors: Galehdarifard Atefeh , Khademi Mojgan , Gholami Mohammad , Radfar Moloud , Ebrahimzadeh Farzad , Imani-Nasab Mohammad-Hasan
Published: April 2023

Background
Although it has been reported that there is a relationship between empathetic behaviors and the reduction in cardiovascular events, some evidence revealed a lack of empathy among nurses. Accordingly, some interventions are required to be conducted for improving empathy among cardiac nurses. This study aimed to determine the effect of knowledge brokering on cardiac nurses' empathy with their patients.
Methods
This is a field randomized controlled trial conducted on a total of 100 cardiac nurses. Participants were assigned to two groups of control and intervention using stratified random allocation. In the intervention group, knowledge brokering was performed at seven stages, including personal assessment; horizon scanning; knowledge management; knowledge translation and exchange; network development, maintenance and facilitation; knowledge facilitation and skill development; and receiving the support of managers for individual changes. Data were collected using Empathy Construct Rating Scale (ECRS) and then analyzed using IBM SPSS Statistics for Windows, version 21 (IBM Corp., Armonk, N.Y., USA). The significance level was considered less than 0.05. The independent-samples t-test was utilized to compare the mean empathy scores before the intervention. The paired-samples t-test and the generalized linear model (with the identity link function) were respectively used to conduct the within- and between-group comparisons after the intervention.
Results
After the completion of the intervention, the mean changes of empathy score (± standard deviation) of empathy was shown to be 1.14 ± 27.73 in the control group (p = .773) and 11.02 ± 35.39 in the intervention group (p = .032). The difference in the mean changes of empathy score was significant between the two groups (p = .042).
Conclusion
Knowledge brokering can promote the level of empathy among cardiac nurses.
Adsorptive Removal of Dimethyl Phthalate Using Peanut Shell Derived Biochar from Aqueous Solutions: Equilibrium, Kinetics and Mechanistic Studies.
Authors: Ghosh Saptarshi , Sahu Manoranjan
Published: April 2023

Rise in polymer industry and extensive use of their products leads to leaching of phthalate esters and distributed into the different matrices of the environment. These chemical group has the potential to hamper the life of living organisms and ecosystem. Thus, it is essential to develop cost effective adsorbents capable of removing these harmful compounds from the environment. In this work, peanut hull derived biochar was taken as the adsorbent, and DMP was selected as the model pollutant or adsorbates. The biochar’s of different properties were produced at three pyrolysis temperature (i.e., 450,550, and 650°C) to check how temperature affected the adsorbent properties and adsorption performance. Consequently, performance of biochar’s for DMP adsorption were thoroughly studied by the combination of experiments and compared with commercial activated carbon (CAC). All the adsorbents are meticulously characterized using various analytical techniques and used for adsorption DMP from aqueous solutions. The results suggested that adsorption was favoring chemisorption with multi-layered adsorption as adsorption kinetics and isotherm are in good alignment with pseudo second order kinetics and Freundlich isotherm, respectively. Further, thermodynamic study revealed DMP adsorption on adsorbent is physically spontaneous and endothermic. The removal efficiency order of four adsorbent was as follows: BC650 > CAC > BC550 > BC450 with maximum efficiency of 98.8% for BC650 followed by 98.6% for CAC at optimum conditions. And, as it’s a short carbon chain PAE, dominant mechanisms of adsorption for DMP onto porous biochar were H-bonding, π-π EDA interactions, and diffusion within the pore spaces. Therefore, this study can provide strategies for the synthesis of biochar for effectively removing DMP from aqueous solution.
Evaluation of Melatonin protective effect on reducing oxidative stress and apoptosis by placental transfer of Methadone in Mice
Authors: Akbarzadeh Maryam , Nemati Farkhondeh , Depouri Abasali , Shaki Fatemeh , Ataee Ramin
Published: April 2023

Methadone is a substance widely used in the substitution treatment of opiate addiction in pregnancy. The placental transfer of methadone influences oxidative stress processes. Melatonin is the hormone with antioxidant activity. This study aimed to evaluate the protective effects of melatonin on oxidative stress induced by transfer of transplacental methadone in mice After breading and mating periods,the female mice (25-30 gm, 2 months old) were divided into 6 groups (6 mice per group) of control, Methadone (0.3 mg/kg intraperitoneal, single dose) and melatonin (0.2, 0.4, and 0.6 mg/kg/day gavage) administered 30 minutes before methadone and one group received melatonin alone(0.6 mg/kg) . All groups were received as a single injection. Administration for 10 consecutive days of pregnancy period were done. After Baby mice were born, all neonatal mice were killed with beheading. Then, the liver tissues were brought out. Then samples were gone for studying of oxidative stress markers as lipid peroxidation (LPO), glutathione (GSH), and protein carbonyl (PrC) contents.Also for assaying apoptosis we have used immunohistochemistry method for BAX, Bcl2 and Caspase3. This study has shown that methadone caused a significant decrease in GSH concentration<0.05. Also were observed a significant increase in lipid peroxidation (LPO) and protein carbonyl contents<0.05. However, melatonin treatment significantly inhibited oxidative stress markers<0.05 .Also apoptosis assay has shown that melatonin could decrease BAX and Caspase 3 as apoptotic proteins and increased Bcl2 as anti-apoptotic protein (P<0.05).Our findings have shown that melatonin has a protective effect against oxidative stress and apoptosis induced by placental transfer of methadone via its antioxidant effects.
Outcome of Ceftriaxone resistant, Escherichia-coli and Klebsiella spp. bacteremia comparing Carbapenem and Beta-lactam/Beta-lactamase inhibiters in a public sector hospital from Pakistan
Authors: Rani Beena , Dodani Sunil Kumar , Mushtaq Maryam , Babar Zaheer Uddin , Badlani Sanjay , Jamil Sana , Fatima Mehreen , Nasim Asma
Published: April 2023

Introduction: Carbapenem are recommended for the treatment of Ceftriaxone (CRO) resistant Enterobacterales, however, there are concerns of cost and resistance. Our aim is to compare the outcome of CRO resistant E-coli and Klebsiella bacteremia between Carbapenem and Beta-lactam/beta-lactamase inhibitors (BL/BLI).Methods A prospective cohort study conducted from October 2021 to June 2022. All adult patients with E coli or Klebsiella spp. bacteremia, CRO resistant and sensitive to both BL/BLI and Carbapenem were included. The patients were divided into BL/BLI and Carbapenem groups. Demographics, clinical features, comorbidities, laboratory parameters and intensive care unit stay were compared. Outcomes were bacteriological clearance, clinical success and all-cause mortality at day 14 of bacteremia.Results A total of 156 patients, 93(59.6%) in BL/BLI and 63(40%) in Carbapenem group were included. There was no difference in co-morbidities, risk factors and severity of disease. The 14 day all-cause mortality was 14.1%. No statistically significant difference was found between BL/BLI and Carbapenem group regarding bacteriological clearance (p = 0.27) and mortality (p = 0.95). The Carbapenem group had less clinical success rate (69.8% vs 82.8%, p = 0.057), however not statistically significant.Conclusion BL/BLIs were as effective as Carbapenem in microbiological clearance, clinical success and mortality in CRO resistant E-coli and Klebsiella bacteremia.
Green synthesis, characterization and Photocatalytic Reduction of Congo red using Silver Nanoparticles from Millingtonia hortensis leaf extract
Authors: Muthu K. , Thangapushbam V. , Rama P. , Sivakami S. , Jothika M.
Published: April 2023

Day-to-day increasing in the usage of organic dye and disposed waste has increases the environmental pollution. So there is an emergency need to removal of toxic dyes solution itself non-toxic. In the present work, green synthesis of silver nanoparticles (Ag NPs) from silver ions using the reducing and capping agent of Millingtonia hortensis leaf broth. UV-Vis absorbance spectral value at 423 nm was confirmed the product of Ag NPs. X-ray diffraction (XRD) analysis and selected area electron diffraction (SAED) pattern was confirm the crystalline nature of metallic silver. High resolution transmission electron microscope (HRTEM)analysis morphology of images identified the spherical shape particles with sizes from 20 to 50nm. The product of Ag NPs was applied as photocatalyst in the reduction/degradation of Congo red in the presence of NaBH4 under different experimental conditions to confirm the pseudo first order kinetics. The Ag NPs was good photocatalyst in the reduction/degradation of Congo red within 14 min.
M1A and m7G modification-related genes are potential biomarkers for survival prognosis and for deciphering the tumor immune microenvironment in esophageal squamous cell carcinoma
Authors: Wang Ruixi , Cheng Xingyuan , Chi Dongmei , Liu Shiliang , Li Qiaoqiao , Chen Baoqing , Xi Mian
Published: April 2023

Background: Esophageal squamous cell carcinoma (ESCC) is the most common esophageal malignancy, and RNA methylation has been reported to be involved in the tumorigenesis of ESCC. However, no study has explored methylation modifications in m1A and m7G as prognostic markers for survival prediction in ESCC.Methods: Public gene-expression data and clinical annotation of 254 patients obtained from The Cancer Genome Atlas and the Gene Expression Omnibus databases were analyzed to identify potential consensus clusters of m1A and m7G modification-related genes. The RNA-seq of 20 patients in Sun Yat-Sen University Cancer Center was used as the validation set. Following screening for relevant differentially expressed genes (DEGs) and enrichment pathways were elucidated. DEGs were used to construct risk models using the randomForest algorithm, and the prognostic role of the models was assessed by applying Kaplan-Meier analysis. Extent of immune cell infiltration, drug resistance, and response to cancer treatment among different clusters and risk groups were also evaluated.Results: Consensus clustering analysis based on m1A and m7G modification patterns revealed three potential clusters. In total, 212 RNA methylation-related DEGs were identified. The methylation-associated signature consisting of 6 genes was then constructed to calculate methylation-related score (MRScore) and patients were dived into MRScore-high and MRScore-low groups. This signature has satisfying prognostic value for survival of ESCC (AUC = 0.66,0.67,0.64 for 2-, 3-, 4- year OS), and has satisfied performance in the validation SYSUCC cohort (AUC = 0.66 for 2- and 3-year OS). Significant correlation between m1A and m7G modification-related genes and immune cell infiltration, and drug resistance was also observed.Conclusions: Transcriptomic prognostic signatures based on m1A and m7G modification-related genes are closely associated with immune cell infiltration in ESCC patients and have important correlations with the therapeutic sensitivity of multiple chemotherapeutic agents.
A Survey of Asian Eye Institutions on Perioperative Antibiotic Prophylaxis in Cataract Surgery
Authors: Garg Prashant , Khor Wei-Boon , Roy Aravind , Tan Donald Tiang-Hwee
Published: April 2023

Purpose: To determine current institutional practice patterns for the use of perioperative antibiotics and other measures to prevent infection after cataract surgery in Asia.
Methods: An online survey-based study of leading eye institutions in China, Hong Kong, India, Indonesia, Japan, Malaysia, Pakistan, Philippines, Singapore, South Korea, Taiwan, Thailand and Vietnam. The survey was administered to 26 representative key opinion leaders from prominent tertiary eye institutions that are also national academic teaching institutions in Asia. Survey responses were collated and anonymized during analysis.
Results: All surveyed institutions used povidone iodine for the pre-operative antiseptic preparation of the eye, with notable variations in the concentration of povidone iodine used for conjunctival sac instillation. Pre-operative topical antibiotics were prescribed by 61.5% and 69.2% of institutions in low-risk and high-risk cases, respectively. Regarding the use of intra-operative antibiotics, 60.0% and 66.7% of institutions administered intracameral antibiotics in low-risk and high-risk patients, respectively. Post-operative topical antibiotics use patterns were generally very similar in low-risk and high-risk patients. Over half of the institutions (52.2% and 68.0% in low-risk and high-risk patients, respectively) also indicated prolonged post-operative use of topical antibiotics (>2 weeks). Not all surveyed institutions had established policies/protocols for perioperative antibiotic use in cataract surgery, endophthalmitis surveillance, and/or a monitoring program for emerging antimicrobial resistance.
Conclusion: There are variations in antimicrobial prophylaxis approaches to pre-operative, intra-operative and post-operative regimens in cataract surgery in Asia. More evidence-based research is needed to support the development of detailed guidelines for perioperative antibiotic prophylaxis to reduce post-operative infections.
Evaluation of environmental knowledge and sustainable behaviour of forest dwellers with reference to forest resource management in the Kashmir Himalayas
Authors: Thoker Irshad Ahmad , Bhat M. Shafi , Shah Shamim Ahmad , Lone Fayaz Ahmad , Mir Sumira , Parrey Hilal Ahmad
Published: April 2023

The study aims to ascertain the levels of environmental knowledge among forest dwellers in the Kashmir Himalayas as it exerts a strong influence on people’s attitude and sustainable behaviour towards sustainable forest resource management. The study is based on primary data, which was analysed with the help of Descriptive Statistics and the Binary Logistic Regression Model (BLRM) in SPSS. The study reveals that environmental knowledge had a Weighted Average Index (WAI) and a Standard Deviation (SD) of 3.05 ± 1.38, indicating low levels of knowledge. The attitude registered a WAI and SD of 3.29 ± 1.33, followed by sustainable behaviour with a WAI and SD of 3.30 ± 1.33, signifying a low to moderate level of attitude and sustainable behaviour, respectively. The study indicates that forest dwellers displayed a positive attitude and desirable behaviour on issues pertaining to their livelihoods. Environmental knowledge pertaining to emerging global environmental issues such as the role of forests in combating global warming, greenhouse gas emissions, climate change, and ecological imbalance was found to be very low, primarily on account of low levels of education. In addition, the attitude towards wildlife conservation was non-congenial on account of increasing man-animal conflicts in the region. The study reveals that education, age, and gender were key determinants influencing people’s environmental knowledge, attitude, and sustainable behaviour. Therefore, efforts should be made to enhance the environmental knowledge of forest dwellers through education and broad-based awareness programmes to inculcate a positive attitude and sustainable behaviour towards forest resource management in this fragile Himalayan valley.
How Has the Shared Bike and Subway Ridership Integration in New York City Changed in Response to the Covid-19 Pandemic?
Authors: Chung Hyungchul , Chen Zihao , Duan Qiaonan
Published: April 2023

The COVID-19 pandemic has hit the world and made significant impacts on all parts of human settlement areas. Passenger journeys on public transportation have dropped significantly. This study looks at the effects of the COVID-19 on the change of bike usage-subway ridership integration between 2019 and 2020 in New York City (NYC), USA. To investigate the effect, this study uses various data sources including bike sharing data from Citi Bike, subway ridership data from Metropolitan Transportation Authority, Census data from IPUMS, land use data from Department of City Planning (DCP) and transportation-related data from U.S. Department of Transportation (DOT). The Geographically Weighted Regression was employed to examine the spatiotemporal varying effects of bike-subway integration for casual users and subscribers in the shared bike system. The results show that the pandemic impacted the usage of bike-subway integration spatially and temporally. The bike-transit integration impact is largely positive and tends to be stronger when the subway stations are located farther away from CBD areas in 2019, while the bike-subway integration tend to be insignificant for a large number of stations in 2020. It also confirms that the impact of the shared bike usage on subway ridership during workdays present a larger magnitude of the coefficients than the ones on non-workdays in 2019. In contrast, the 2020 model shows that the impacts do not differ between workdays and non-workdays. These findings are rarely discussed in earlier studies. This study also used an 800-meter boundary captures the spatial impact of shared bike usage on subway ridership in NYC. However, it is barely discussed what network typologies determines such a spatial boundary of the shared bike impact area. This will be further discussed in future research.
Selenium Biomarkers and Their Relationship to Cardiovascular Risk Parameters in Obese Women
Authors: Cardoso Bruna Emanuele Pereira , Dias Thaline Milany Silva , Fontenelle Larissa Cristina , Morais Jennifer Beatriz Silva , Cruz Kyria Jayanne Climaco , Sousa Mickael Paiva , Sousa Thayanne Gabryelle Visgueira , Melo Stéfany Rodrigues Sousa , Santos Loanne Rocha dos , Henriques Gilberto Simeone , Oliveira Francisco Erasmo , Soares Tamires da Cunha , Marreiro Dilina do Nascimento
Published: April 2023

A cross-sectional study was carried out with 210 women divided into a case group (obese, n=84) and a control group (eutrophic, n=126). Body weight, height and waist circumference, hip and neck circumference were measured and the waist-hip ratio and conicity index were calculated. Selenium in plasma, erythrocytes and urine, erythrocyte GPx activity, lipid profile, Castelli I and II index, and systolic and diastolic blood pressure were evaluated. Mean dietary selenium intake (µg/kg/day) and plasma and erythrocyte concentrations were lower in the obese group compared to the healthy group (p<0.001). while urinary selenium concentrations were higher (p<0.001). There was a statistical difference between groups regarding cardiovascular risk parameters: waist circumference, neck circumference, waist-hip ratio, conicity index, triacylglycerols and VLDL-c (p>0.05). There was a negative correlation between plasma selenium concentrations and total cholesterol, not HDL, LDL-c and systolic blood pressure. Urinary selenium correlated negatively with waist circumference, hip circumference and positively with neck circumference, total cholesterol, triacylglycerols, HDL-c, non-HDL and VLDL-c. There was a negative correlation between dietary selenium and waist circumference, waist-hip ratio, neck circumference, conicity index, non-HDL cholesterol, LDL-c, Castelli index I and II, as well as a positive correlation with HDL-c and diastolic blood pressure . Women with obesity present changes in their nutritional status related to selenium, as well as increased cardiovascular risk parameters. Thus, the positive role of selenium in protecting the risk of cardiovascular disease is likely.
Numerical study of the circulation and its contribution to the oil slick transport in the southeastern part of the Black Sea
Authors: Demetrashvili Demuri , Kukhalashvili Vepkhia , Kvaratskhelia Diana
Published: April 2023

The relevance of studying and forecasting regional circulation and the spread of impurities in the shelf/coastal zones of the seas is determined by intensive human economic activity, which causes a large anthropogenic load on coastal marine ecosystems. The aim of this paper is to study the mesoscale circulation under real atmospheric forcing and its contribution to the oil slick transport in the southeastern part of the Black Sea using a regional model of the Black Sea dynamics (RM-IG) and a 2-D oil slick transport model, which is coupled to the RM-IG. The RM-IG with 1 km horizontal resolution is based on a z-level primitive equations system of ocean hydrothermodynamics. During the EC project ARENA (2003–2005) the RM-IG was nested in the basin-scale model of the Black Sea dynamics of Marine Hydrophysical Institute (Sevastopol, Ukraine) with 5 km horizontal resolution. The transport model is based on 2-D advection-diffusion equation for non-conservative substances. Atmospheric forcing is taken into account by prognostic meteorological fields derived from the atmospheric model SKIRON. Numerical experiments have shown that during all seasons there is a generation, deformation, and disappearance of anticyclonic and cyclonic meso- and submesoscale vortex formations, which have a significant impact on the pollutants dispersion process. Intensive vortex formations are observed during light winds. Strong winds have a smoothing effect and prevent the formation of vortex structures. In a number of cases, the unstable eddy formations with a diameter of 5–20 km are generated in a narrow strip along the Georgian coast presenting a width of about 20–30 km.
Review on the Recipe, Making Procedure and Availability of Mixed Tea in the Joseon Dynasty Period, Korea
Authors:   Association for International Tea Culture, Lim Seung-jung
Published: April 2023

In this paper, in order to find out the recipes, making procedure and drinking methods of Korean indigenous teas, 『Jeungbo Forest Economy』,『Gosasibijip』,『Imwonsipyukji』,『Gunhakhoedeung』,『Joseon Cuisine Recipe』,『Chosun invincible cooking recipe』,『Simple Joseon cooking recipe』 which are cookbooks of the Joseon Dynasty Period were investigated. As a results, there were found 23 types of tea including yuzu tea which is still drink, and among them, Gugi tea, Chrysanthemum tea, Kiguk tea, Gingertangerine tea, and Cheongcheon Baekseok tea were suggested in this thesis, especially about recipe, making procedure, and drinking method of them. These teas were mixed teas containing tea leaves and plant flower, fruit can be popularized. It is considered that if more research is conducted on making procedure and drinking methods of teas in accordance with modern times, and various methods of using tea are presented, it will help expand the base of the Korean tea population.
Dynamic damage and response characteristics of the tunnel by FEM modeling and field trials
Authors: Zheng Xianjun , Wu Tingyao , Wu Chao , Wang Xiaoqin
Published: April 2023

The dynamic response characteristics of the tunnel and the stability of the surrounding rock are crucial to its safety of the tunnel. Combining the numerical simulation software and field measurement results, the change of peak particle vibration (PPV) and stress were analyzed, based on the longitudinal wave data from the acoustic tests, the blasting damage effects under the action of different blasting counts, including different locations in the deep part of the surrounding rock, were investigated. The results show that: (1) in the vertical direction of the tunnel, the PPV of the tunnel floor and tunnel sidewall is larger, the PPV of the tunnel top is the second, and the tunnel arch shoulder and arch foot is the smallest; (2) under the action of blasting, the stress concentration at the tunnel bottom and arch foot is easier, and the stress monitoring should be strengthened; (3) The depth of damage at different distances was 1.5 m and 3.0 m, respectively, and the depth of damage to the surrounding rock increased from 2.5 m to 4.0 m when the number of blasts was 10 and the number of blasts was 10.
Aldehyde Dehydrogenases as Promising Targets for Treating Toxic
Aldehyde-related Diseases
Authors: Chen Yu , Li Xin
Published: April 2023

Background:

Mammals are exposed to various endogenous and exogenous aldehydes,
and aldehyde dehydrogenases (ALDHs) function to metabolize these aldehydes
into acids in order to counteract aldehyde over-load. ALDHs, therefore, play important
roles in a series of physiological and pathophysiological processes. ALDHs activators and
inhibitors are not only important probes for exploring ALDHs functions, but promising
for the treatment of toxic aldehyde-related diseases.

Methods:

This review has comprehensively summarized the categories and characteristics
of 19 human ALDHs, elaborated their related biological pathways, such as alcohol metabolism,
retinoic acid (RA) production, neurotransmitter metabolism, etc. In addition, reported
ALDHs activators and inhibitors have been summarized by listing their target, inhibition
form, and clinical application.

Results:

On the one hand, summarization of the types and relative functions is useful for
further research on aldehyde metabolic pathways and related diseases. On the other hand,
a review of existing activators and inhibitors of ALDHs contributes to discovering new
leading compounds and provides new insights.

Conclusion:

In consideration of the important role ALDH plays in toxic aldehyde-related
diseases, ALDHs are promising targets for the treatment of toxic aldehyde-related diseases,
and more research efforts are required to explore their pathophysiology and to develop
new regulators.
PBPK Modeling as an Alternative Method of Interspecies Extrapolation
that Reduces the Use of Animals: A Systematic Review
Authors: Lancheros Porras Karen Dayana , Alves Izabel Almeida , Novoa Diana Marcela Aragón
Published: April 2023

Introduction:

Physiologically based pharmacokinetic (PBPK) modeling is a computational
approach that simulates the anatomical structure of the studied species and presents
the organs and tissues as compartments interconnected by arterial and venous blood flows.

Aim:

The aim of this systematic review was to analyze the published articles focused on
the development of PBPK models for interspecies extrapolation in the disposition of
drugs and health risk assessment, presenting to this modeling an alternative to reduce the
use of animals.

Methods:

For this purpose, a systematic search was performed in PubMed using the following
search terms: “PBPK” and “Interspecies extrapolation”. The revision was performed
according to PRISMA guidelines.

Results:

In the analysis of the articles, it was found that rats and mice are the most commonly
used animal models in the PBPK models; however, most of the physiological and
physicochemical information used in the reviewed studies were obtained from previous
publications. Additionally, most of the PBPK models were developed to extrapolate
pharmacokinetic parameters to humans and the main application of the models was for
toxicity testing.

Conclusion:

PBPK modeling is an alternative that allows the integration of in vitro and in
silico data as well as parameters reported in the literature to predict the pharmacokinetics
of chemical substances, reducing in large quantity the use of animals that are required in
traditional studies.
Molecular Mechanism of Tau Misfolding and Aggregation: Insights
from Molecular Dynamics Simulation
Authors: Zhong Haiyang , Liu Hongli , Liu Huanxiang
Published: April 2023

Tau dysfunction has a close association with many neurodegenerative diseases,
which are collectively referred to as tauopathies. Neurofibrillary tangles (NFTs)
formed by misfolding and aggregation of tau are the main pathological process of tauopathy.
Therefore, uncovering the misfolding and aggregation mechanism of tau protein will
help to reveal the pathogenic mechanism of tauopathies. Molecular dynamics (MD) simulation
is well suited for studying the dynamic process of protein structure changes. It provides
detailed information on protein structure changes over time at the atomic resolution.
At the same time, MD simulation can also simulate various conditions conveniently.
Based on these advantages, MD simulations are widely used to study conformational
transition problems such as protein misfolding and aggregation. Here, we summarized
the structural features of tau, the factors affecting its misfolding and aggregation, and the
applications of MD simulations in the study of tau misfolding and aggregation.
The Structure-property Relationships of Clinically Approved
Protease Inhibitors
Authors: Choi Kihang
Published: April 2023

Background:

Proteases play important roles in the regulation of many physiological
processes, and protease inhibitors have become one of the important drug classes.
Especially because the development of protease inhibitors often starts from a substrate-
based peptidomimetic strategy, many of the initial lead compounds suffer from pharmacokinetic
liabilities.

Objective:

To reduce drug attrition rates, drug metabolism and pharmacokinetics studies
are fully integrated into modern drug discovery research, and the structure-property relationship
illustrates how the modification of the chemical structure influences the pharmacokinetic
and toxicological properties of drug compounds. Understanding the structure-
property relationships of clinically approved protease inhibitor drugs and their analogues
could provide useful information on the lead-to-candidate optimization strategies.

Methods:

About 70 inhibitors against human or pathogenic viral proteases have been approved
until the end of 2021. In this review, 17 inhibitors are chosen for the structure-
property relationship analysis because detailed pharmacological and/or physicochemical
data have been disclosed in the medicinal chemistry literature for these inhibitors
and their close analogues.

Results:

The compiled data are analyzed primarily focusing on the pharmacokinetic or
toxicological deficiencies found in lead compounds and the structural modification strategies
used to generate candidate compounds.

Conclusion:

The structure-property relationships hereby summarized how the overall
druglike properties could be successfully improved by modifying the structure of protease
inhibitors. These specific examples are expected to serve as useful references and
guidance for developing new protease inhibitor drugs in the future.
Archive management to support information services of the administration section
Authors: Supiatni Ni Nyoman , Kencanawati Anak Agung Ayu Mirah , Suryaniadi Sagung Mas , Narti Ni Ketut , Sitawati Anak Agung Raka
Published: April 2023

The purpose of this study is to explain archive management in supporting information services in the administration section. The research method used is a qualitative approach with a descriptive type of research. The results obtained from the research explain that the creation of archives through incoming and outgoing letters, the distribution of archives is carried out through procedures written in the standard operating procedures for distributing letters in government agencies, the storage of archives is carried out with a numbering system, the use of archives through retrieval and borrowing of archives, maintenance of archives carried out regularly every two months; Archive depreciation is only carried out by transferring archives to the warehouse. However, there are obstacles in its management, namely the absence of archivists, insufficient storage cupboards, and no archive management training while the supports are adequate storage warehouses and administrative staff who are painstaking in managing archive.
A study of the extended model of the theory of planned behavior using the perceived support model
Authors: Tahir Muhammad , Kutpudeen Mohammed
Published: April 2023

There is a greater interest in understanding entrepreneurship intentions among youngsters and researchers frequently use the theory of planned behavior (TPB) for this purpose. However, factors influencing the TPB components are little explored. Keeping in view the research gap, in the present study, the TPB model is extended based on the Perceived Support Model. Thus, the objective is to test the effects of the three dimensions (educational, relational, and structural) of the perceived support model on the components of the TPB. The study is based on a cross-sectional survey method of data collection and the sample consists of Omani youngsters in the age range of 18 to 30 years (n=662). The analysis includes Confirmatory Factor Analysis for establishing the reliability and validity; and path analysis for testing the hypotheses. The results show an insignificant influence of perceived educational support on all of the dimensions of the TPB; while a positive and significant influence of perceived relational support on all the dimensions of the TPB. Furthermore, the result shows a positive and significant influence of perceived structural support on subjective norms and perceived behavioral control. Finally, attitude, subjective norms, and perceived behavioral control have positive and significant effects on entrepreneurship intention. Overall, our result shows that the perceived support model can be used to understand entrepreneurial intentions as well as the components of TPB. A number of recommendations are made based on the findings of the study.
Исследование микроструктуры люминофоров для лазерных осветительных устройств
Authors: Зуев С.М. , Кретушев А.В.
Published: April 2023

A brief description is given of phosphors from various manufacturers that can be used in lighting devices with laser injection in the range of 400–480 nm. An estimate of their energy output and inertia is given. The necessity of studying various types of luminescence to optimize the characteristics of phosphor lighting devices is described. It is known that the optical characteristics of laser lighting devices depend on the quality of the phosphor. However, at the moment there are no well-established methods for studying phosphors for compliance with the requirements for brightness, luminous flux, and thermal degradation. One of these methods can be microscopy, which allows you to study the microstructure of samples. The paper considers a method for determining the geometric and optical parameters of individual phosphor particles used for laser lighting devices using microscopy. On the example of a fine suspension of phosphors, images were obtained and some optical parameters of individual particles with diameters from 40 to 150 nm were determined. The conducted studies demonstrate the high resolution of the microscopy method, which can be used to visualize phosphor particles.
Методика оптического детектирования метана волоконно-оптическом сенсором при применении фотокаталитического нанокомпозита ZnO-SnO-=SUB=-2-=/SUB=--Fe-=SUB=-2-=/SUB=-O-=SUB=-3-=/SUB=-
Authors: Хомутинникова Л.Л. , Мешковский И.К. , Евстропьев С.К. , Литвинов М.Ю. , Быков Е.П. , Плясцов С.А.
Published: April 2023

The possibility of detection of methane using fiber-optical sensor with ZnO-SnO2-Fe2O3 photocatalyst was demonstrated. Photocatalytic composite sensor element was prepared by non-isothermal polymer-salt method from solutions of inorganic metal salts and polyvinylpyrrolidone. Optical detection is carrying out by Bragg diffraction grating of fiber-optical sensor at the temperature variations during photocatalytic methane oxidation.
Consumer Perception, Nutritional, and Technological Properties of Bread Made with Chickpea Flour
Authors: Aguirre Alicia , El Khori Sandra , Borneo Rafael
Published: April 2023

Celiac disease (CD) is one of the most common intestinal diseases in humans today. The only "cure" for this disease is a strictly gluten-free diet. Bread is a highly accepted food product. But, bread is a product that owns its technological properties to the presence of gluten. Bread without gluten has different texture, palatability, and sensorial properties. Therefore, new products are needed to solve this problem. Chickpeas are an inexpensive source of protein for making gluten-free baked goods. In this study, we explored a gluten-free bread formula made with chickpea flour and examined the consumer profile of chickpea bread and its nutritional and technical properties. Results showed that chickpeas could be an alternative raw material for meeting the consumer needs of people who need (or prefer) gluten-free products/diets.