bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effects of Propofol or Dexmedetomidine Sedation on Postoperative Recovery in Elderly Patients Receiving Lower Limb Surgery under Spinal Anesthesia: A Retrospective Propensity Score-Matched Analysis
Authors: Park Jin-Woo , Kim Eun-Kyoung , Lee Hun-Taek , Park Seongjoo , Do Sang-Hwan
Published: January 2021

Propofol and dexmedetomidine are the two most popular intravenous sedatives during anesthesia. However, data comparing the effects of these two sedatives during spinal anesthesia on postoperative recovery are still insufficient. We retrospectively analyzed the medical records of patients aged ≥65 years who underwent orthopedic surgery under spinal anesthesia between March 2012 and February 2017. The patients were allocated into two groups according to the intraoperative sedatives: the propofol group and dexmedetomidine group. We analyzed the incidence of postoperative delirium, analgesic requirement, and rescue anti-emetic treatment. A total of 1045 patients were included in the analysis. After propensity score matching with the propofol group, the dexmedetomidine group showed a lower incidence of postoperative delirium (odds ratio, 0.19; 95% CI, 0.07–0.56; p = 0.011). Postoperative analgesic and anti-emetic requirement were not significantly different between the two groups (p = 0.156 and 0.245, respectively). Multivariate logistic regression analysis revealed that intraoperative sedation, age, preoperative albumin level, and hip surgery were significantly associated with the incidence of postoperative delirium. This study showed that intraoperative dexmedetomidine sedation under spinal anesthesia during lower limb surgery is associated with a lower incidence of postoperative delirium compared with propofol sedation.
Progression of Interstitial Fibrosis and Tubular Atrophy in Low Immunological Risk Renal Transplants Monitored by Sequential Surveillance Biopsies: The Influence of TAC Exposure and Metabolism
Authors: Chamoun Betty , Torres Irina B. , Gabaldón Alejandra , Sellarés Joana , Perelló Manel , Castellá Eva , Guri Xavier , Salcedo Maite , Toapanta Nestor G. , Cidraque Ignacio , Moreso Francesc , Seron Daniel
Published: January 2021

The combination of tacrolimus (TAC) and mycophenolate is the most widely employed maintenance immunosuppression in renal transplants. Different surrogates of tacrolimus exposure or metabolism such as tacrolimus trough levels (TAC-C0), coefficient of variation of tacrolimus (CV-TAC-C0), time in therapeutic range (TTR), and tacrolimus concentration dose ratio (C/D) have been associated with graft outcomes. We explore in a cohort of low immunological risk renal transplants (n = 85) treated with TAC, mycophenolate mofetil (MMF), and steroids and then monitored by paired surveillance biopsies the association between histological lesions and TAC-C0 at the time of biopsy as well as CV-TAC-C0, TTR, and C/D during follow up. Interstitial inflammation (i-Banff score ≥ 1) in the first surveillance biopsy was associated with TAC-C0 (odds ratio (OR): 0.69, 95% confidence interval (CI): 0.50–0.96; p = 0.027). In the second surveillance biopsy, inflammation was associated with time below the therapeutic range (OR: 1.05 and 95% CI: 1.01–1.10; p = 0.023). Interstitial inflammation in scarred areas (i-IFTA score ≥ 1) was not associated with surrogates of TAC exposure/metabolism. Progression of interstitial fibrosis/tubular atrophy (IF/TA) was observed in 35 cases (41.2%). Multivariate regression logistic analysis showed that mean C/D (OR: 0.48; 95% CI: 0.25–0.92; p = 0.026) and IF/TA in the first biopsy (OR: 0.43, 95% CI: 0.24–0.77, p = 0.005) were associated with IF/TA progression between biopsies. A low C/D ratio is associated with IF/TA progression, suggesting that TAC nephrotoxicity may contribute to fibrosis progression in well immunosuppressed patients. Our data support that TAC exposure is associated with inflammation in healthy kidney areas but not in scarred tissue.
Effect of Coronal Alignment on 10-Year Survivorship of a Single Contemporary Total Knee Arthroplasty
Authors: Tibbo Meagan E. , Limberg Afton K. , Perry Kevin I. , Pagnano Mark W. , Stuart Michael J. , Hanssen Arlen D. , Abdel Matthew P.
Published: January 2021

Debate remains regarding the utility of mechanical axis alignment as a predictor of durability after total knee arthroplasty (TKA). Our study aimed to assess the effects of coronal alignment on implant durability, clinical outcomes, and radiographic results with a single fixed-bearing TKA design. All patients undergoing primary cemented TKA of a single design (Stryker Triathlon) from 2005–2007 with >10 years of follow-up and available pre-operative and post-operative hip–knee–ankle radiographs were included (n = 89). Radiographs were measured to determine coronal alignment and assessed for loosening. Mean preoperative mechanical axis alignment was −6° ± 6.7° (varus, range, −16°–23°), while mean post-operative alignment was −1° ± 2.7° (varus, range, −3°–15°). The aligned group was defined as knees with a post-operative mechanical axis of 0° ± 3° (n = 73) and the outlier group as those outside this range (n = 16). No patients underwent revision. Ten-year survivorship free from any reoperation was 99% and 100% in the aligned and outlier groups, respectively (p = 0.64). Knee Society scores improved significantly in both groups (p < 0.001) and did not differ at final follow-up (p = 0.15). No knees demonstrated radiographic evidence of loosening. Post-operative mechanical axis alignment within 3° of neutral was not associated with improved implant durability, clinical outcomes, or radiographic results at 10 years following primary TKA.
Hybrid Joining by Induction Heating of Basalt Fiber Reinforced Thermoplastic Laminates
Authors: Al-Obaidi Amar , Kimme Jonas , Kräusel Verena
Published: January 2021

Induction heating was used to join basalt fiber reinforced polymer laminates (BFRPL) using the process called inductive contact joining (ICJ). Two other mechanical joining processes, nut and bolt (NB) and two-piece hollow riveting (2PR), were compared to ICJ. The obtained joints were evaluated using tensile shear tests and by analyzing fractured surfaces. Furthermore, simulation of the ICJ process was used to estimate the effective parameters. Joints produced by ICJ had superior joint strength compared to joints manufactured by 2PR. In addition, during ICJ, the BFRPL fibers were not damaged and the strength of the base material was maintained. The tensile shear forces of the ICJ process exceeded 3.5 kN and 2.5 kN for a joined, sandblasted aluminum sheet with BFRPL and for joining BFRPL to itself, respectively. Further optimization potential of the ICJ process was discovered during the investigation, so that potentially higher joint strengths and shorter processing times can be expected, making the process interesting for future industrial applications.
Relative Sea Level Changes and Morphotectonic Implications Triggered by the Samos Earthquake of 30th October 2020
Authors: Evelpidou Niki , Karkani Anna , Kampolis Isidoros
Published: January 2021

On 30th October 2020, the eastern Aegean Sea was shaken by a Mw = 7.0 earthquake. The epicenter was located near the northern coasts of Samos island. This tectonic event produced an uplift of the whole island as well as several cases of infrastructure damage, while a small tsunami followed the mainshock. Underwater and coastal geological, geomorphological, biological observations and measurements were performed at the entire coast revealing a complex character for the uplift. At the northwestern part of the island, maximum vertical displacements of +35 ± 5 cm were recorded at the northwestern tip, at Agios Isidoros. Conversely, the southeastern part was known for its subsidence through submerged archaeological remains and former sea level standstills. The 2020 underwater survey unveiled uplifted but still drowned sea level indicators. The vertical displacement at the south and southeastern part ranges between +23 ± 5 and +8 ± 5 cm suggesting a gradual fading of the uplift towards the east. The crucial value of tidal notches, as markers of co-seismic events, was validated from the outcome of this study. The co-seismic response of Samos coastal zone to the 30th October earthquake provides a basis for understanding the complex tectonics of this area.
Signals and Images in Sea Technologies
Authors: Moroni Davide , Salvetti Ovidio
Published: January 2021

Life below water is the 14th Sustainable Development Goal (SDG) envisaged by the United Nations and is aimed at conserving and sustainably using the oceans, seas and marine resources for sustainable development [...]
Hospital Environment as a Source of Azole-Resistant Aspergillus fumigatus Strains with TR34/L98H and G448S Cyp51A Mutations
Authors: Gonzalez-Jimenez Irene , Lucio Jose , Menéndez-Fraga Maria Dolores , Mellado Emilia , Peláez Teresa
Published: January 2021

Azole-resistant Aspergillus fumigatus is an emerging worldwide problem with increasing reports of therapy failure cases produced by resistant isolates. A case of azole-resistant A. fumigatus hospital colonization in a patient is reported here. Investigations of the hospital environment led to the recovery of A. fumigatus strains harboring the TR34/L98H and the G448S Cyp51A azole resistance mechanisms. Isolate genotyping showed that one strain from the environment was isogenic with the patient strains. These are the first environmental A. fumigatus azole resistant strains collected in a hospital in Spain; it supports the idea of the hospital environment as a source of dissemination and colonization/infection by azole resistant A. fumigatus in patients. The isolation of an azole-resistant strain from an azole-naïve patient is an interesting finding, suggesting that an effective analysis of clinical and environmental sources must be done to detect azole resistance in A. fumigatus. The emergence and spread of these resistance mechanisms in A. fumigatus is of major concern because it confers high resistance to voriconazole and is associated with treatment failure in patients with invasive aspergillosis.
Public Perceptions on City Landscaping during the Outbreak of Coronavirus Disease: The Case of Vilnius Pop-Up Beach, Lithuania
Authors: Pranskuniene Rasa , Perkumiene Dalia
Published: January 2021

The article sought to understand public perceptions on city landscaping during the outbreak of COVID-19. The research aimed to discuss the theoretical aspects related to restrictions on travel during the pandemic and city landscaping and to conduct an empirical study of experiences of the Vilnius Pop-up Beach, Lithuania. The thematic analysis selected for the empirical study is not limited and flexible, allowing for revealing the experiences and public opinion, including that expressed in the media, relating to the Vilnius Pop-up Beach. The analysis resulted in the identification of several themes: "Nostalgia for heroic landscape", "Changing memory landscape", and "Enjoying the landscape of freedom", which demonstrated the controversy surrounding the changing city landscape. Analysis showed the interaction of public perceptions on city landscaping. The results of this research highlight the importance in future sustainable landscape development of paying attention to the different city experiences. Public perceptions should be heard and respected when considering the unique landscape of the past, present, and future and its impact on city memories. Thus, possible directions for future research should include more in-depth explorations on alternative travel experiences, looking for possible uncovered, unforeseen, sensitive, and meaningful travel experiences, which emerged during the outbreak of COVID-19.
Comparison of Simple Averaging and Latent Class Modeling to Estimate the Area of Land Cover in the Presence of Reference Data Variability
Authors: Xing Dingfan , Stehman Stephen V. , Foody Giles M. , Pengra Bruce W.
Published: January 2021

Estimates of the area or percent area of the land cover classes within a study region are often based on the reference land cover class labels assigned by analysts interpreting satellite imagery and other ancillary spatial data. Different analysts interpreting the same spatial unit will not always agree on the land cover class label that should be assigned. Two approaches for accommodating interpreter variability when estimating the area are simple averaging (SA) and latent class modeling (LCM). This study compares agreement between area estimates obtained from SA and LCM using reference data obtained by seven trained, professional interpreters who independently interpreted an annual time series of land cover reference class labels for 300 sampled Landsat pixels. We also compare the variability of the LCM and SA area estimates over different numbers of interpreters and different subsets of interpreters within each interpreter group size, and examine area estimates of three land cover classes (forest, developed, and wetland) and three change types (forest gain, forest loss, and developed gain). Differences between the area estimates obtained from SA and LCM are most pronounced for the estimates of wetland and the three change types. The percent area estimates of these rare classes were usually greater for LCM compared to SA, with the differences between LCM and SA increasing as the number of interpreters providing the reference data increased. The LCM area estimates generally had larger standard deviations and greater ranges over different subsets of interpreters, indicating greater sensitivity to the selection of the individual interpreters who carried out the reference class labeling.
Respiratory and Systemic Toxicity of Inhaled Artificial Asian Sand Dust in Pigs
Authors: Kim Keon , Kim Seon-Deuk , Shin Tae-Hoon , Bae Chun-Sik , Ahn Taeho , Shin Sung-Shik , Kim Ha-Jung , Lee Chang-Min , Suh Guk-Hyun
Published: January 2021

Air pollution, particularly caused by Asian sand dust (ASD) and particulate matter (PM), has become one of the leading threats to public health. However, the majority of studies have primarily focused on epidemiological assessment, and in vivo toxicities of certain air pollutants have been poorly elucidated in medium/large-size laboratory animals. To investigate the impact of ASD in domestic animals, 16 Landrace pigs were exposed to an artificial ASD sandstorm for 6 h. All animals were divided in four cages, and a commercial yellow soil was used for generating artificial mineralogical particles. Blood samples were collected, and necropsies were performed before exposure and 6, 12, 24, and 72 h after exposure. Complete blood cell count and the levels of serum biochemical enzymes, blood gas, electrolytes, and a variety of inflammatory cytokines were evaluated. In addition, histopathological examination was conducted. Various test results proved acute lower airway disorders with systemic inflammation in pigs. To our knowledge, this study is the first to describe experimental research in domestic animals concerning the damage caused by artificial ASD exposure. The results of this study suggest that ASD has importance in terms of not only public health but also of ultimate economic losses in the pork industry.
(S)-1-(Ethoxycarbonyl)ethyl(2R,5S)-2,5-dimethyl-1,3-dioxolan-4-one-2-carboxylate
Authors: Aitken R. , Haslett Oliver , Slawin Alexandra
Published: January 2021

The title compound was obtained in low yield in the condensation of ethyl pyruvate and lactic acid. Its structure is determined by NMR methods and x-ray diffraction and the mechanism for formation of this 1:2 adduct from the initial 1:1 adduct is considered.
Phase Field Study of the Microstructural Dynamic Evolution and Mechanical Response of NiTi Shape Memory Alloy under Mechanical Loading
Authors: Xi Shangbin , Su Yu
Published: January 2021

For the purpose of investigating the microstructural evolution and the mechanical response under applied loads, a new phase field model based on the Ginzburg-Landau theory is developed by designing a free energy function with six potential wells that represent six martensite variants. Two-dimensional phase field simulations show that, in the process of a shape memory effect induced by temperature-stress, the reduction-disappearance of cubic austenite phase and nucleation-growth of monoclinic martensite multi-variants result in a poly-twined martensitic microstructure. The microstructure of martensitic de-twinning consists of different martensite multi-variants in the tension and compression, which reveals the microstructural asymmetry of nickel-titanium (NiTi) alloy in the tension and compression. Furthermore, in the process of super-elasticity induced by tensile or compressive stress, all martensite variants nucleate and expand as the applied stress gradually increases from zero. Whereas, when the applied stress reaches critical stress, only the martensite variants of applied stress-accommodating continue to expand and others fade gradually. Moreover, the twinned martensite microstructures formed in the tension and compression contain different martensite multi-variants. The study of the microstructural dynamic evolution in the phase transformation can provide a significant reference in improving properties of shape memory alloys that researchers have been exploring in recent years.
Preparation and Swelling Behaviors of High-Strength Hemicellulose-g-Polydopamine Composite Hydrogels
Authors: Ge Jiayan , Gu Kaiqi , Sun Kewen , Wang Xinyue , Yao Shuangquan , Mo Xiaorong , Long Shuilian , Lan Tingting , Qin Chengrong
Published: January 2021

Hemicellulose-based composite hydrogels were successfully prepared by adding polydopamine (PDA) microspheres as reinforcing agents. The effects of PDA microsphere size, dosage, and nitrogen content in hydrogel on the mechanical and rheological properties was studied. The compressive strength of hydrogel was increased from 0.11 to 0.30 MPa. The storage modulus G’ was increased from 7.9 to 22.0 KPa. The gaps in the hemicellulose network are filled with PDA microspheres. There is also chemical cross-linking between them. These gaps increased the density of the hydrogel network structure. It also has good water retention and pH sensitivity. The maximum cumulative release rate of methylene blue was 62.82%. The results showed that the release behavior of hydrogel was pH-responsive, which was beneficial to realizing targeted and controlling drug release.
Enhanced Crystallinity and Luminescence Characteristics of Hexagonal Boron Nitride Doped with Cerium Ions According to Tempering Temperatures
Authors: Jung Jae Yong , Kim Juna , Kim Yang Do , Kim Young-Kuk , Cha Hee-Ryoung , Lee Jung-Goo , Son Chang Sik , Hwang Donghyun
Published: January 2021

Hexagonal boron nitride was synthesized by pyrolysis using boric acid and melamine. At this time, to impart luminescence, rare earth cerium ions were added to synthesize hexagonal boron nitride nanophosphor particles exhibiting deep blue emission. To investigate the changes in crystallinity and luminescence according to the re-heating temperature, samples which had been subjected to pyrolysis at 900 °C were subjected to re-heating from 1100 °C to 1400 °C. Crystallinity and luminescence were enhanced according to changes in the reheating temperature. The synthesized cerium ion-doped hexagonal boron nitride nanoparticle phosphor was applied to the anti-counterfeiting field to prepare an ink that can only be identified under UV light.
Deformation Characteristics and Constitutive Equations for the Semi-Solid Isothermal Compression of Cold Radial Forged 6063 Aluminium Alloy
Authors: Wang Yongfei , Zhao Shengdun , Guo Yi , Liu Kuanxin , Zheng Shunqi
Published: January 2021

Al-Mg-Si based alloys are popular alloys used in the automotive industry. However, limited studies have been performed to investigate the microstructure, deformation characteristics, and deformation mechanism for the semi-solid 6063 alloys. In this study, the cold radial forging method and semi-solid isothermal treatment (SSIT) are proposed in the semi-solid isothermal compression (SSIC) process to fabricate high-quality semi-solid 6063 billets. The effects of deformation temperature, strain rate, and strain on the microstructure, deformation characteristics, and deformation mechanism of the SSIC of cold radial forged 6063 alloys were investigated experimentally. Constitutive equations were established based on the measured data in experiments to predict the flow stress. Results show that an average grain size in the range from 59.22 to 73.02 μm and an average shape factor in the range from 071 to 078 can be obtained in the microstructure after the cold radial forged 6063 alloys were treated with SSIT process. Four stages (i.e., sharp increase, decrease, steady state, and slow increase) were observed in the true stress- true strain curve. The correlation coefficient of the constitutive equation was obtained as 0.9796 while the average relative error was 5.01%. The deformation mechanism for SSIC of cold radial forged aluminum alloy 6063 mainly included four modes: The liquid phase flow, grain slide or grain rotation along with the liquid film, slide among solid grains, and the plastic deformation of solid grains.
Characterization of PLA/PBSeT Blends Prepared with Various Hexamethylene Diisocyanate Contents
Authors: Kim Sun Jong , Kwak Hyo Won , Kwon Sangwoo , Jang Hyunho , Park Su-il
Published: January 2021

Poly (lactic acid) (PLA) is the most widely available commercial bioplastic that is used in various medical and packaging applications and three-dimensional filaments. However, because neat PLA is brittle, it conventionally has been blended with ductile polymers and plasticizers. In this study, PLA was blended with the high-ductility biopolymer poly (butylene-sebacate–co–terephthalate) (PBSeT), and hexamethylene diisocyanate (HDI) was applied as a crosslinking compatibilizer to increase the miscibility between the two polymers. PLA (80%) and PBSeT (20%) were combined with various HDI contents in the range 0.1–1.0 parts-per-hundred rubber (phr) to prepare blends, and the resulting physical, thermal, and hydrolysis properties were analyzed. Fourier-transform infrared analysis confirmed that –NH–C=OO− bonds had formed between the HDI and the other polymers and that the chemical bonding had influenced the thermal behavior. All the HDI-treated specimens showed tensile strengths and elongations higher than those of the control. In particular, the 0.3-phr-HDI specimen showed the highest elongation (exceeding 150%) and tensile strength. In addition, all the specimens were hydrolyzed under alkaline conditions, and all the HDI-treated specimens degraded faster than the neat PLA one.
Validating the Methods to Process the Stress Path in Multiaxial High-Cycle Fatigue Criteria
Authors: Papuga Jan , Cízová Eva , Karolczuk Aleksander
Published: January 2021

The paper discusses one of the key features in the multiaxial fatigue strength evaluation—the procedure in which the stress path is analyzed to provide relevant measures of parameters required by multiaxial criteria. The selection of this procedure affects the complete equivalent stress derived for any multiaxial load combinations. Three major concepts—the minimum circumscribed circle, minimum circumscribed ellipse, and moment of inertia methods—are described. Analytical solutions of their evaluation for multiaxial stress state with components described by harmonic functions are provided. The concepts are validated on available experimental data when included into six different multiaxial fatigue strength criteria. The results show that the moment of inertia results in too conservative results. Differences between both methods of circumscribed entities are much smaller. There are indications however that the minimum circumscribed ellipse solution works better for critical plane criteria and for the criteria based on stress tensor transformation into the Ilyushin deviatoric space. On the other hand, the minimum circumscribed ellipse solution tends to shift integral criteria to the conservative side.
Role of Co in the Electrocatalytic Activity of Monolayer Ternary NiFeCo-Double Hydroxide Nanosheets for Oxygen Evolution Reaction
Authors: Li Ye , Zhao Dan , Shi Yue , Sun Zhicheng , Liu Ruping
Published: January 2021

Monolayer nanosheets have gained significant attention as functional materials and also in photo/electrocatalysis due to their unique physical/chemical properties, abundance of highly exposed coordination sites, edges, and corner sites, motivating the pursuit of highly active monolayer nanosheets. NiFe-based layered double hydroxide (NiFe-LDH) nanosheets have been regarded as the most efficient electrocatalysis for oxygen evolution. However, the limited catalytic active site and the stacking layer limited the performance. Therefore, by introducing highly electroactive Co ions into monolayer NiFe-LDH, the obtained ternary NiFeCo-LDH monolayer structure possessed an increased concentration of defect (oxygen and metal vacancies), providing enough unsaturated coordination sites, benefitting the electrocatalytic water oxidation, as also explained by the density functional theory (DFT). This work reported an efficient strategy for the synthesis of ternary monolayer LDH in the application of energy conversion and storage.
An Overview of the Hamilton–Jacobi Theory: the Classical and Geometrical Approaches and Some Extensions and Applications
Authors: Román-Roy Narciso
Published: January 2021

This work is devoted to review the modern geometric description of the Lagrangian and Hamiltonian formalisms of the Hamilton–Jacobi theory. The relation with the “classical” Hamiltonian approach using canonical transformations is also analyzed. Furthermore, a more general framework for the theory is also briefly explained. It is also shown how, from this generic framework, the Lagrangian and Hamiltonian cases of the theory for dynamical systems are recovered, as well as how the model can be extended to other types of physical systems, such as higher-order dynamical systems and (first-order) classical field theories in their multisymplectic formulation.
Anterior Capsule Opening Contraction and Late Intraocular Lens Dislocation after Cataract Surgery in Patients with Weak or Partially Absent Zonular Support
Authors: Vanags Juris , Erts Renārs , Laganovska Guna
Published: January 2021

Background and Objectives: To evaluate anterior capsule opening (ACO) contraction and late intraocular lens (IOL) dislocation after cataract surgery in patients with weak or partially absent zonular support and assess methods of reducing these complications. Materials and Methods: For this prospective study, we enlisted cataract surgery patients in our hospital with preoperative diagnoses of weak zonules. All patients received phacoemulsification surgery with implantation of a hydrophobic acrylic IOL and capsular tension ring (CTR). ACO reductions were measured for six months after enrolment. Data on late IOL dislocations were collected five years after enrolment of the last patient. Results: Fifty-three patients were enrolled from 2011 to 2015. Over the six-month active follow-up period, ACO area reduction was 23% in patients receiving CTRs of 11 mm diameter and 8% for patients with CTRs of 12 mm, with an overall mean of 15% reduction. Five years after the last patient was enrolled, seven patients (13%) had experienced late IOL-CTR-capsular bag dislocation. For these patients, the mean ACO reduction in the first six months of follow-up was 33%, including for those who had received neodymium-doped yttrium aluminum garnet (Nd: YAG) anterior capsulotomies. Conclusion: Use of hydrophobic acrylic lenses and CTR reduces ACO contraction, with rates comparable to those after cataract surgery without ocular comorbidity. Our patients experienced a relatively high rate of late IOL-CTR-capsular bag dislocation. However, dislocated complexes were easily repositioned and few patients required IOL exchange. Frequent visits are warranted to promptly detect late complications of cataract surgery in patients with weak zonular support.
A Comparison of the Epidemiology, Clinical Features, and Treatment of Acute Osteomyelitis in Hospitalized Children in Latvia and Norway
Authors: Thingsaker Elise Evja , Urbane Urzula Nora , Pavare Jana
Published: January 2021

Background and objectives: Paediatric acute osteomyelitis (AO) may result in major life-threatening and limb-threatening complications if not recognized and treated early. The management of AO may depend on local microbial prevalence and virulence factors. This study compares the approach to paediatric AO in hospitals in two countries—Latvia and Norway. Materials and Methods: The study includes patients with AO hospitalized in the paediatric department in the Norwegian hospital Sørlandet Sykehus Kristiansand (SSK), in the period between the 1st of January 2012 and the 31st of December 2019. The results from SSK are compared to the results of a published study of AO in patients hospitalized at the Children’s Clinical University Hospital (CCUH) in Riga, Latvia. Results: The most isolated pathogen from cultures in both hospitals was S. aureus (methicillin-sensitive). The lower extremity was the most affected body part (75% in CCUH, 95% in SSK), the main clinical symptom was pain (CCUH 92%, SSK 96.6%). Deep culture aspiration was most often taken intraoperatively in CCUH (76.6%) and percutaneously in SSK (44.8%). Oxacillin was the most applied antibiotic in CCUH (89.4%), and Cloxacillin in SSK (84.6%). Combined treatment with anti-Staphylococcal penicillins and Clindamycin was administered in 25.5% and 33.8% of CCUH and SSK patients, respectively. The median duration of the intravenous antibacterial treatment in CCUH and SSK was 15 and 10 days, respectively, and a switch to oral therapy was mainly made at discharge in both hospitals. The median total duration of antibiotic treatment was 25 days in CCUH and 35 days in SSK. 75% of CCUH and 10.3% of SSK patients were treated surgically. Complications were seen in 47% of patients in CCUH and in 38% in SSK. Conclusions: The transition to oral antibacterial treatment in both hospitals was delayed, which suggests a lack of criteria for discontinuation of intravenous therapy and could potentially contribute to longer hospitalization, higher cost of treatment and risk of complications. The use of more invasive techniques for deep culturing and significantly more common surgical interventions could possibly be linked to a higher complication rate in AO patients treated at the Latvian hospital.
The Joint Effects of Nitriding and Parameters Related to the Destabilisation of Austenite on Wear Resistance in White Cast Iron with 25% Cr
Authors: González-Pociño Alejandro , Alvarez-Antolin Florentino , Asensio-Lozano Juan
Published: January 2021

In this article, the effects of an ionic nitriding treatment are analysed, together with deliberate variation of different thermal parameters associated with the destabilisation of austenite, on erosive wear resistance of white cast irons with 25% Cr. The methodology followed in this research was an experimental design, where six factors were analyzed by performing eight experiments. The thickness of the nitrided layer is much smaller than in white cast iron with lower percentages in Cr, never reaching 20 microns. The nitriding treatment entails considerable softening of the material underneath the nitriding layer. This softening behaviour becomes partially inhibited when the destabilisation temperature of austenite is 1100 °C and dwell times at such temperature are prolonged. This temperature seems to play a significant role in the solubilization of non-equilibrium eutectic carbides, formed during industrial solidification. The nitriding treatment leads to additional hardening, which, in these cases, favours a second destabilisation of austenite, with additional precipitation of secondary carbides and the transformation of retained austenite into martensite. Despite softening of the material, the nitriding treatment, together with air-cooling after destabilisation of the austenite, allows a noticeable increase in resistance to erosive wear.
Metabolic Detoxification of 2-Oxobutyrate by Remodeling Escherichia coli Acetate Bypass
Authors: Fang Yu , Zhang Shuyan , Wang Jianli , Yin Lianghong , Zhang Hailing , Wang Zhen , Song Jie , Hu Xiaoqing , Wang Xiaoyuan
Published: January 2021

2-Oxobutyrate (2-OBA), as a toxic metabolic intermediate, generally arrests the cell growth of most microorganisms and blocks the biosynthesis of target metabolites. In this study, we demonstrated that using the acetate bypass to replace the pyruvate dehydrogenase complex (PDHc) in Escherichia coli could recharge the intracellular acetyl-CoA pool to alleviate the metabolic toxicity of 2-OBA. Furthermore, based on the crystal structure of pyruvate oxidase (PoxB), two candidate residues in the substrate-binding pocket of PoxB were predicted by computational simulation. Site-directed saturation mutagenesis was performed to attenuate 2-OBA-binding affinity, and one of the variants, PoxBF112W, exhibited a 20-fold activity ratio of pyruvate/2-OBA in substrate selectivity. PoxBF112W was employed to remodel the acetate bypass in E. coli, resulting in l-threonine (a precursor of 2-OBA) biosynthesis with minimal inhibition from 2-OBA. After metabolic detoxification of 2-OBA, the supplies of intracellular acetyl-CoA and NADPH (nicotinamide adenine dinucleotide phosphate) used for l-threonine biosynthesis were restored. Therefore, 2-OBA is the substitute for pyruvate to engage in enzymatic reactions and disturbs pyruvate metabolism. Our study makes a straightforward explanation of the 2-OBA toxicity mechanism and gives an effective approach for its metabolic detoxification.
Spread of Carbapenem-Resistant Gram-Negatives and Candida auris during the COVID-19 Pandemic in Critically Ill Patients: One Step Back in Antimicrobial Stewardship?
Authors: Magnasco Laura , Mikulska Malgorzata , Giacobbe Daniele Roberto , Taramasso Lucia , Vena Antonio , Dentone Chiara , Dettori Silvia , Tutino Stefania , Labate Laura , Di Pilato Vincenzo , Crea Francesca , Coppo Erika , Codda Giulia , Robba Chiara , Ball Lorenzo , Patroniti Nicolo’ , Marchese Anna , Pelosi Paolo , Bassetti Matteo
Published: January 2021

The possible negative impact of severe adult respiratory distress caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection (COVID-19) on antimicrobial stewardship and infection control has been postulated, but few real-life data are available. The aim of this study was to report our experience with colonization/infection of carbapenem-resistant Pseudomonas aeruginosa (CRPA), carbapenem-resistant Klebsiella pneumoniae (CR-Kp) and Candida auris among critically ill COVID-19 patients admitted to the intensive care unit (ICU). All COVID-19 patients admitted to the ICUs at San Martino Policlinico Hospital–IRCCS in Genoa, Italy, were screened from 28 February to 31 May 2020. One-hundred and eighteen patients admitted to COVID-19 ICUs were included in the study. Among them, 12 (10.2%) became colonized/infected with CRPA, 6 (5.1%) with C. auris and 2 (1.6%) with CR-Kp. All patients with CRPA received prior treatment with meropenem, and in 11 (91.7%) infection was not preceded by colonization. Four patients (66.7%) developed C. auris candidemia. A significant spread of resistant pathogens was observed among critically ill COVID-19 patients. Dedicated strategies are warranted to prevent horizontal spread and maintain effective antimicrobial stewardship programs in the setting of COVID-19 care.
Klebsiella pneumoniae Chorioamnionitis: An Underrecognized Cause of Preterm Premature Rupture of Membranes in the Second Trimester
Authors: Bonasoni Maria Paola , Palicelli Andrea , Dalla Dea Giulia , Comitini Giuseppina , Nardini Paola , Vizzini Loredana , Russello Giuseppe , Bardaro Marcellino , Carretto Edoardo
Published: January 2021

Klebsiella pneumoniae is a Gram-negative, rod-shaped bacterium, responsible for hospital and community acquired pneumonia, urinary tract and wound infections, and bloodstream dissemination. K. pneumoniae infection in pregnancy, leading to acute chorioamnionitis (AC), preterm premature rupture of membranes (PPROM) and early pregnancy loss in the second trimester, has been rarely reported. Herein, we present a case of K. pneumoniae AC that caused intrauterine fetal demise (IUFD) at 19 weeks + 5 days. The 36-year-old mother was admitted at 18 weeks + 1 day of gestation for threatened abortion. IUFD occurred 11 days after. Fetal postmortem showed severe AC and funisitis, neutrophils within alveoli and intestinal lumen, associated with rod-like bacteria. Fetal blood and lung cultures grew K. pneumoniae, β-lactamase-non-producing strain. Antibiogram revealed sensitivity for piperacillin/tazobactam. Three days after IUFD, the mother presented with fever (37.8 °C) which persisted for one week. Maternal blood and urine cultures were negative. According to fetal microbiological results, available 6 days after IUFD, initial treatment with amoxicillin/clavulanic acid was replaced with piperacillin/tazobactam with full patient recovery. Therefore, in the event of PPROM and IUFD, fetal microbiological investigations should always be performed to isolate the proper etiologic agent and start the correct medical treatment.
Designing the Hotspots Distribution by Anisotropic Growth
Authors: Li Tianshun , Gao Renxian , Zhang Xiaolong , Zhang Yongjun
Published: January 2021

Changing the morphology of noble metal nanoparticles and polarization dependence of nanoparticles with different morphologies is an important part of further research on surface plasma enhancement. Therefore, we used the method based on Matlab simulation to provide a simple and effective method for preparing the morphologies of Au nanoparticles with different morphologies, and prepared the structure of Au nanoparticles with good uniformity and different morphologies by oblique angle deposition (OAD) technology. The change of the surface morphology of nanoparticles from spherical to square to diamond can be effectively controlled by changing the deposition angle. The finite difference time domain (FDTD) method was used to simulate the electromagnetic fields of Au nanoparticles with different morphologies to explore the polarization dependence of nanoparticles with different shapes, which was in good agreement with Raman spectrum.
Iron Chelation in Local Infection
Authors: Scott Cassidy , Arora Gaurav , Dickson Kayle , Lehmann Christian
Published: January 2021

Iron is an essential element in multiple biochemical pathways in humans and pathogens. As part of the innate immune response in local infection, iron availability is restricted locally in order to reduce overproduction of reactive oxygen species by the host and to attenuate bacterial growth. This physiological regulation represents the rationale for the therapeutic use of iron chelators to support induced iron deprivation and to treat infections. In this review paper we discuss the importance of iron regulation through examples of local infection and the potential of iron chelation in treating infection.
Sustainable Triazine-Based Dehydro-Condensation Agents for Amide Synthesis
Authors: Sole Roberto , Gatto Vanessa , Conca Silvia , Bardella Noemi , Morandini Andrea , Beghetto Valentina
Published: January 2021

Conventional methods employed today for the synthesis of amides often lack of economic and environmental sustainability. Triazine-derived quaternary ammonium salts, e.g., 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMTMM(Cl)), emerged as promising dehydro-condensation agents for amide synthesis, although suffering of limited stability and high costs. In the present work, a simple protocol for the synthesis of amides mediated by 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) and a tert-amine has been described and data are compared to DMTMM(Cl) and other CDMT-derived quaternary ammonium salts (DMT-Ams(X), X: Cl− or ClO4−). Different tert-amines (Ams) were tested for the synthesis of various DMT-Ams(Cl), but only DMTMM(Cl) could be isolated and employed for dehydro-condensation reactions, while all CDMT/tert-amine systems tested were efficient as dehydro-condensation agents. Interestingly, in best reaction conditions, CDMT and 1,4-dimethylpiperazine gave N-phenethyl benzamide in 93% yield in 15 min, with up to half the amount of tert-amine consumption. The efficiency of CDMT/tert-amine was further compared to more stable triazine quaternary ammonium salts having a perchlorate counter anion (DMT-Ams(ClO4)). Overall CDMT/tert-amine systems appear to be a viable and more economical alternative to most dehydro-condensation agents employed today.
Copper Complexes as Alternative Redox Mediators in Dye-Sensitized Solar Cells
Authors: Colombo Alessia , Dragonetti Claudia , Roberto Dominique , Fagnani Francesco
Published: January 2021

Thirty years ago, dye-sensitized solar cells (DSSCs) emerged as a method for harnessing the sun’s energy and converting it into electricity. Since then, a lot of work has been dedicated to improving their global photovoltaic efficiency and their eco-sustainability. Recently, various articles showed the great potential of copper complexes as a convenient and cheap alternative to the traditional ruthenium dyes. In addition, copper complexes demonstrate that they can act as redox mediators for DSSCs, thus being an answer to the problems related to the I3−/I− redox couple. The aim of this review is to report on the most recent impact made by copper complexes as alternative redox mediators. The coverage, mainly from 2016 up to now, is not exhaustive, but allows us to understand the great role played by copper complexes in the design of eco-sustainable DSSCs.
The Exchange of Cyclometalated Ligands
Authors: Ryabov Alexander D.
Published: January 2021

Reactions of cyclometalated compounds are numerous. This account is focused on one of such reactions, the exchange of cyclometalated ligands, a reaction between a cyclometalated compound and an incoming ligand that replaces a previously cyclometalated ligand to form a new metalacycle: + H-C*~Z ⇄ + H-C~Y. Originally discovered for PdII complexes with Y/Z = N, P, S, the exchange appeared to be a mechanistically challenging, simple, and convenient routine for the synthesis of cyclopalladated complexes. Over four decades it was expanded to cyclometalated derivatives of platinum, ruthenium, manganese, rhodium, and iridium. The exchange, which is also questionably referred to as transcyclometalation, offers attractive synthetic possibilities and assists in disclosing key mechanistic pathways associated with the C–H bond activation by transition metal complexes and C–M bond cleavage. Both synthetic and mechanistic aspects of the exchange are reviewed and discussed.
A Concise Review on the Physicochemical Properties of Biopolymer Blends Prepared in Ionic Liquids
Authors: Shamsuri Ahmad Adlie , Abdan Khalina , Kaneko Tatsuo
Published: January 2021

An enhancement of environmental concern lately has improved the awareness of researchers in employing eco-friendly solvents for processing biopolymers. Recently, ionic liquids have been utilized to prepare biopolymer blends as they are non-volatile and recyclable. Biopolymers such as cellulose, chitin, chitosan, keratin, lignin, silk, starch, and zein are widely used for the preparation of biopolymer blends via dissolution in ionic liquids, followed by coagulation procedure. In this concise review, three types of ionic liquids based on imidazolium cations combined with different counter anions that are frequently utilized to prepare biopolymer blends are described. Moreover, three types of biopolymer blends that are prepared in ionic liquids were classified, specifically polysaccharide/polysaccharide blends, polysaccharide/polypeptide blends, and polysaccharide/bioplastic blends. The physicochemical properties of biopolymer blends prepared in different imidazolium-based ionic liquids are also concisely reviewed. This paper may assist the researchers in the polymer blend area and generate fresh ideas for future research.
Thermodynamics of the Vapor–Liquid–Solid Growth of Ternary III–V Nanowires in the Presence of Silicon
Authors: Hijazi Hadi , Zeghouane Mohammed , Dubrovskii Vladimir
Published: January 2021

Based on a thermodynamic model, we quantify the impact of adding silicon atoms to a catalyst droplet on the nucleation and growth of ternary III–V nanowires grown via the self-catalyzed vapor–liquid–solid process. Three technologically relevant ternaries are studied: InGaAs, AlGaAs and InGaN. For As-based alloys, it is shown that adding silicon atoms to the droplet increases the nanowire nucleation probability, which can increase by several orders magnitude depending on the initial chemical composition of the catalyst. Conversely, silicon atoms are found to suppress the nucleation rate of InGaN nanowires of different compositions. These results can be useful for understanding and controlling the vapor–liquid–solid growth of ternary III–V nanowires on silicon substrates as well as their intentional doping with Si.
Exceedingly High Performance Top-Gate P-Type SnO Thin Film Transistor with a Nanometer Scale Channel Layer
Authors: Yen Te Jui , Chin Albert , Gritsenko Vladimir
Published: January 2021

Implementing high-performance n- and p-type thin-film transistors (TFTs) for monolithic three-dimensional (3D) integrated circuit (IC) and low-DC-power display is crucial. To achieve these goals, a top-gate transistor is preferred to a conventional bottom-gate structure. However, achieving high-performance top-gate p-TFT with good hole field-effect mobility (μFE) and large on-current/off-current (ION/IOFF) is challenging. In this report, coplanar top-gate nanosheet SnO p-TFT with high μFE of 4.4 cm2/Vs, large ION/IOFF of 1.2 × 105, and sharp transistor’s turn-on subthreshold slopes (SS) of 526 mV/decade were achieved simultaneously. Secondary ion mass spectrometry analysis revealed that the excellent device integrity was strongly related to process temperature, because the HfO2/SnO interface and related μFE were degraded by Sn and Hf inter-diffusion at an elevated temperature due to weak Sn–O bond enthalpy. Oxygen content during process is also crucial because the hole-conductive p-type SnO channel is oxidized into oxygen-rich n-type SnO2 to demote the device performance. The hole μFE, ION/IOFF, and SS values obtained in this study are the best-reported data to date for top-gate p-TFT device, thus facilitating the development of monolithic 3D ICs on the backend dielectric of IC chips.
The Design, Characterization and Antibacterial Activity of Heat and Silver Crosslinked Poly(Vinyl Alcohol) Hydrogel Forming Dressings Containing Silver Nanoparticles
Authors: Jackson John , Burt Helen , Lange Dirk , Whang In , Evans Robin , Plackett David
Published: January 2021

The prompt treatment of burn wounds is essential but can be challenging in remote parts of Africa, where burns from open fires are a constant hazard for children and suitable medical care may be far away. Consequently, there is an unmet need for an economical burn wound dressing with a sustained antimicrobial activity that might be manufactured locally at low cost. This study describes and characterizes the novel preparation of a silver nitrate-loaded/poly(vinyl alcohol) (PVA) film. Using controlled heating cycles, films may be crosslinked with in situ silver nanoparticle production using only a low heat oven and little technical expertise. Our research demonstrated that heat-curing of PVA/silver nitrate films converted the silver to nanoparticles. These films swelled in water to form a robust, wound-compatible hydrogel which exhibited controlled release of the antibacterial silver nanoparticles. An optimal formulation was obtained using 5% (w/w) silver nitrate in PVA membrane films that had been heated at 140 °C for 90 min. Physical and chemical characterization of such films was complemented by in vitro studies that confirmed the effective antibacterial activity of the released silver nanoparticles against both gram positive and negative bacteria. Overall, these findings provide economical and simple methods to manufacture stable, hydrogel forming wound dressings that release antibiotic silver over prolonged periods suitable for emergency use in remote locations.