bluuebunny/crossref_metadata_2025 huggingface dataset:
Acute and Subacute Oral Toxicity Characterization and Safety Assessment of COVID Organics® (Madagascar’s Anti-COVID Herbal Tea) in Animal Models
Authors: Aina Oluwagbemiga Olarewaju , Okoyenta Onyinye Celestina , Okolo Clemen Abu , Kareem Kafilat Olaide , Ajibaye Olusola , Adeogun Adedapo O. , Salako Babatunde L.
Published: October 2023

Introduction:

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2. No drug has been generally approved as safe and effective for the treatment of COVID-19. Several therapeutic agents such as COVID Organics® (CVO) have been explored as treatment options. CVO is an herbal tea composed of 62% of Artemisia
annua and 38% of other plants. There is presently no existing scientific report and data on the safety and efficacy of CVO herbal drug. Thus, acute and subacute toxicity studies were undertaken to evaluate the safety and toxicity of CVO on short- and long-term usage in animal models.

Materials and Methods:

Phytochemical and nutritional compositions of CVO were determined using standard methods. Acute oral toxicity was investigated using female Swiss albino mice (three per group). While subacute oral toxicity was done using female and male Swiss albino rats (five per group). The animals were administered 2000 mg/kg, 5000 mg/kg, therapeutic dose; 5500 mg/kg and supratherapeutic dose; 11,000 mg/kg of CVO herbal product. The control group received water ad
libitum. The oral toxicity studies were done in accordance with Organization for Economic Corporation and Development guidelines. The experimental protocol was approved by the Institutional Animal Care and Use Committee, Nigerian Institute of Medical Research (Ethics No. IRB/17/043).

Results:

CVO is rich in antioxidants: flavonoids (10.3%), tannins (29.1%), and phenolics (434.4 mg). It contains proteins (33.8%), carbohydrates (34.5%), fat (6.8%), and fiber (0.5%). In the acute toxicity study, no mortality was recorded in all the treated and untreated groups. The lethal dose of CVO is >5000 mg/kg body weight. The hematological, biochemical, lipid profile, and histologic parameters were all normal at therapeutic doses when compared to the control group.

Conclusion:

The acute and subacute oral toxicity studies revealed that CVO is not toxic. The specific organ toxicity evaluations also indicated that CVO has no toxic effects on blood parameters and vital organs structure and function at therapeutic dose. Thus, CVO is safe for short- and long-term usage. We recommend that CVO should be subjected to efficacy studies to investigate whether it is effective for COVID-19 treatment as claimed by the manufacturer.
The Comparison of Cerebral Oxygenation among Mechanically Ventilated Children Receiving Protocolized Sedation and Analgesia versus Clinician’s Decision in Pediatric Intensive Care Unit
Authors: Prawira Yogi , Irlisnia  , Oswari Hanifah , Pudjiadi Antonius Hocky , Parwoto Bambang Tridjaja Asmara Apri , Gayatri Anggi
Published: October 2023

Introduction:

Adequate sedation and analgesia are two crucial factors affecting recovery of intensive care patients. Improper use of sedation and analgesia in intensive care patients may adversely lead to brain oxygen desaturation. This study aims to determine cerebral oxygenation as measured by near-infrared spectroscopy (NIRS) and inotropic interventions received among mechanically ventilated children in the pediatric intensive care unit (PICU).

Methods:

This study is a nested case − control study in the PICU of Indonesian tertiary hospital. Children aged 1 month to 17 years on mechanical ventilation and were given sedation and analgesia were included in the study. Subjects were divided into two groups according to the protocol of the main study (Clinical Trial ID NCT04788589). Cerebral oxygenation was measured by NIRS at five time points (before sedation, 5-min, 1, 6, and 12 h after sedation).

Results:

Thirty-nine of the 69 subjects were categorized into the protocol group and the rest were in the control group. A decrease of >20% NIRS values was found among subjects in the protocol group at 5-min (6.7%), 1-h (11.1%), 6-h (26.3%), and 12-h (23.8%) time-point. The mean NIRS value was lower and the inotropic intervention was more common in the control group (without protocol), although not statistically significant.

Conclusion:

This study found that mechanically ventilated children who received sedation and analgesia based on the protocol had a greater decrease of >20% NIRS values compared to the other group. The use of sedation and analgesia protocols must be applied in selected patients after careful consideration.
Представление Дирака группы $SO(3,2)$ и задача Ландау
Authors: Tiwari Suresh Chandra
Published: October 2023

Исследовано бесконечное вырождение спектра и констант движения в задаче Ландау, в результате получены центральное расширение евклидовой группы двумерного пространства как динамической группы симметрии и группа $Sp(2,\mathbb{R})$ как порождающая спектр независимо от выбора калибровки. Важную роль играет метод сжатия группы. Заново рассмотрено замечательное представление Дирака группы $SO(3,2)$ и изоморфизм этой группы и группы $Sp(4,\mathbb{R})$. Представлено новое понимание значения системы двух осцилляторов в представлении Дирака. Утверждается, что, поскольку даже двумерный изотропный осциллятор, имеющий $SU(2)$ в качестве группы динамической симметрии, не возникает в задаче Ландау, актуальность или применимость группы $SO(3,2)$ становится недействительной. Обсуждается модифицированная модель Ландау-Зеемана, в которой естественным образом может возникнуть группа $SO(3,2)$, эквивалентная $Sp(4,\mathbb{R})$.
Earthquake disaster impact on health care of cancer patients: Single center experience
Authors: ÜNSAL Oktay , YAZICI Ozan , YILDIRIM ÖZDEMİR Nuriye , SAVAŞ Gözde , ÖZET Ahmet
Published: October 2023

Background: The earthquakes in February 2023 in Turkey had a major impact on Turkey's health system, causing damage to hospitals and health centres in the affected areas. Cancer patients are one of the groups that are highly influenced by the disaster. The aim of this study was to evaluate some of the demographic and clinical characteristics of cancer patients who are getting health care in earthquake-affected areas.

Material and Methods: Fifty cancer patients who lived in 11 cities of Turkey affected by the earthquake and were admitted to Gazi University Department of Medical Oncology after the earthquake between 15 February 2023 and 15 March 2023 were included in the study. Data such as demographic characteristics, cancer diagnosis, time of cancer treatment, and earthquake history were taken retrospectively from nationally-linked electronic records (E-nabız).

Results: Breast cancer was the most common diagnosis of these patients. Most of the patients were taking active treatment (60%). Chemotherapy and hormonotherapy were the most common treatment modalities (20% and 18%, respectively). The median delay in the active treatment of 14 cancer patients was 24 days (2-60).

Conclusions: The earthquake disaster has led to important impacts on cancer patients' care in most affected areas. The human, financial and medical resources should be improved. Especially if detailed nationally-linked electronic records are provided, cancer patients will not have difficulty seeking health care. This disaster should be an important stimulus for hospitals and healthcare systems to improve the care of patients during disasters.
An underestimated old friend: Serum protein electrophoresis in the differential diagnosis of glomerulopathies
Authors: ŞAHİN Ahmet Bilgehan , BAKKAL Safiye , GÜLLÜLÜ Saide , ORUÇ Ayşegül , YILDIZ Abdülmecit , AYDIN Mehmet Fethullah , ERSOY Alparslan , OCAKOĞLU Gökhan , GÜLLÜLÜ Mustafa
Published: October 2023

Background: Serum protein electrophoresis (SPEP) is an easy test separating serum proteins based on their physical and chemical properties. Although it is frequently used in the differential diagnosis of multiple myeloma and various chronic inflammatory diseases, its value in the etiologic classification of glomerular diseases has yet to be studied.

Material and Methods: We retrospectively reviewed the medical records of patients who underwent renal biopsy from 2008 to 2016 at our institution. We excluded patients who can not be classified as primary (PGn) or secondary glomerulonephritis (SGn). Univariate and multivariate logistic regression analyses were performed for the prediction of SGn.

Results: Four hundred thirty-two patients were included in the study. Of those, 57.9% had PGn. Rheumatological diseases, malignancies, and infections were the most common etiologic causes of SGn, accounting for nearly 75%. Univariate analysis revealed that alpha-1 (α1), gamma (Ɣ), and albumin fractions significantly differ between PGn and SGn groups. ROC curve analysis determined the cut-off value of (α1*Ɣ)/albumin ratio as 1.48. Multivariate analysis revealed that total serum protein and (α1*Ɣ)/albumin ratio were significantly independent predictors for SGn (p=0.020 and p
Análise das propostas de InfoVis para um software de alocação de atividades no ambiente construído
Authors: Pereira Lucas Melchiori , Ornstein Sheila Walbe , Velloso Leandro Manuel Reis
Published: October 2023

Soluções de visualização da informação (Information Visualization: InfoVis) são fundamentais para melhorar a compreensão e o uso de dados complexos. O artigo apresenta os resultados de uma oficina de codesign, que utilizou brainsketching na elaboração de soluções de InfoVis para um software em desenvolvimento de alocação de atividades no ambiente construído. O objetivo é analisar as estratégias de legibilidade apresentadas pelas soluções elaboradas e assim embasar as próximas etapas de desenvolvimento. Os participantes foram introduzidos ao funcionamento do software e aos dados que deviam representar visualmente. Duas equipes multidisciplinares foram formadas por designers e arquitetos para discutir e propor ideias de visualização, comunicando-se por meio de esboços e fala. Receberam materiais de apoio para realizar a atividade de codesign, tais como uma amostra dos dados – obtida por meio do mapeamento de uma alocação real do pronto-socorro de um Hospital Universitário –, cards com visualizações de referência e material de desenho. Os resultados alcançados pelas duas equipes apresentam características que se enquadram em duas estratégias de redução de complexidade da visualização de informação postuladas na teoria consultada. A discussão destes resultados contribui para o enquadramento teórico sobre a prática de InfoVis e oferece insights sobre a visualização no software em desenvolvimento.
Projetar fora da caixa: reflexões sobre experiência didática com foco na criatividade estudantil
Authors: Souza Natalya Cristina de Lima , Elali Gleice Virginia Medeiros de Azambuja
Published: October 2023

Estudos apontam que nos Cursos de Arquitetura e Urbanismo estimular a atividade criativa ligada a diferentes momentos do processo de projeto pode ajudar os estudantes a expressarem seus pensamentos, adquirirem experiências e conhecimentos essenciais à construção do repertório e à elaboração de respostas coerentes com as demandas do futuro profissional. No entanto, poucos cursos trabalham diretamente esse tipo de conteúdo. Diante disso, este artigo objetiva relacionar ideias-chave e atributos sociais de uma experiência didática ocorrida em disciplina optativa com foco na criatividade estudantil, e cuja metodologia incluiu diversos experimentos de consulta aos estudantes. A turma foi continuamente estimulada a sair da zona de conforto e interagir (como um todo e entre todos), numa relação de troca, em que os estudantes cumpriam as atividades propostas em sala de aula, muitas vezes ultrapassando seus limites físicos. No acompanhamento do semestre foram utilizados registro fotográfico e diário de campo. Os resultados apontam: (i) ideias-chave relacionadas aos atributos potenciais da ambiência criativa; (ii) táticas pedagógicas que colaboraram para que alguns estudantes se sentissem mais criativos ao final do semestre. Dentre as contribuições do texto está a listagem de atividades e estratégias que podem ser aplicadas para potencializar a criatividade.
EVALUACIÓN DE LA EFICIENCIA ENERGÉTICA DE UN EDIFICIO PATRIMONIAL DE LA PLATA, ARGENTINA
Authors: Fernandez Juan Matias , Bassualdo Rapetti Julián , Dittler Candela , Gualtieri Pedro , Gómez Analía Fernanda
Published: October 2023

Por más que su valor social y cultural es incuantificable, los edificios patrimoniales no necesariamente contemplan en su diseño la eficiencia energética. Al ser algunos referentes ante la sociedad en la que se implantan, la aplicación de mejoras en estos les permite actuar de modelo ante su entorno, potenciando a la comunidad aplicar esas medidas, sumando acciones contra el cambio climático. Se identificó un edificio patrimonial cumpliendo funciones cívicas en la ciudad de La Plata. Se midió cada componente de su envolvente térmica: carpinterías, muros y cubiertas. Se dialogó con sus usuarios y se estudiaron sus planos, definiendo cuantitativamente conductividad térmica con normas locales y morfología. Se simuló su comportamiento térmico para el período estival y se plantearon mejoras sin modificar partes originales, entre ellas  . Se verificó que observando la normativa local permite lograr un ahorro energético de hasta 54%. Se logró así una propuesta sustentable sin comprometer su patrimonialidad.
Proposta discente na adoção do BIM no ensino de Desenho de Arquitetura
Authors: Guedes de Oliveira Elisabeth , Almeida Allana Rocha de , Salgado Monica Santos , Santana Ethel Pinheiro
Published: October 2023

Este artigo apresenta uma proposta construída a partir da perspectiva de discentes do curso de graduação em arquitetura da FAU UFRJ compartilhando a visão que têm sobre a disciplina intitulada Desenho de arquitetura e as possibilidades oferecidas pelo BIM para o ensino desse conteúdo específico. A proposta considerou: a revisão das alternativas apresentadas nos anais do ENEBIM; os conteúdos programáticos das disciplinas que compõem o currículo do curso de arquitetura da Faculdade; a infraestrutura disponível; e, a experiência em sala de aula. A disciplina de Desenho de arquitetura foi escolhida por ser considerada uma das que poderiam se beneficiar do BIM. Essa percepção empírica, associada às práticas identificadas na revisão da literatura, permitiu a proposta que considera a adoção do BIM como uma estratégia didática. Entende-se, assim, que o ensino de desenho de arquitetura pode se beneficiar da adoção do BIM a partir de atividades que associam diversos sistemas de informação e de representação. Como um novo currículo está sendo implantado, a proposta pode facilmente ser incluída nas práticas em sala de aula, pois combina estratégias já adotadas, na disciplina vigente, com nova abordagem que potencializa as alterações da grade curricular.
Sustentabilidade em Projetos Urbanos: o caso da ZAC francesa
Authors: Luvison Alfredo , Miron Luciana
Published: October 2023

Na França, a Zone d’Aménagement Concerté (ZAC) consolidou-se, enquanto Projeto Urbano (PU), como o principal instrumento de planejamento urbano para renovação e extensão urbanas. Apesar de ter tido influência na criação do instrumento brasileiro da Operação Urbana pouco se sabe sobre a ZAC no Brasil e os estudos que abordam a temática dos PU, em geral, não abordam a questão da sustentabilidade no desenvolvimento das operações. O objetivo deste artigo é identificar como a sustentabilidade é abordada nas ZAC francesas a partir da análise de três objetos empíricos conformando um Estudo de Caso Único Integrado. Constatou-se, a partir disso, que a problemática ambiental está muito incorporada ao processo de projeto e implantação das operações, mas que apesar da tomada de consciência, incentivos financeiros são ainda necessários para que elas se concretizem dessa forma.
Avaliação do ambiente virtual imersivo a partir de uma modelagem BIM: Potenciais para o desenvolvimento de projetos colaborativos
Authors: Mandola Juliana Bambini , Mesiano Allan Jhonathan , Imai César
Published: October 2023

As ferramentas digitais trazem novas abordagens na resolução dos problemas de projeto em relação aos procedimentos tradicionais. A velocidade do surgimento de ferramentas e processos podem demandar uma constante atualização dos processos de projeto. A utilização de instrumentos como o Building Information Modeling (BIM) e a Realidade Virtual (RV) vem ganhando destaque na discussão do projeto, sendo uma das vertentes que pode ser mais explorada nesses processos. Entretanto, faltam pesquisas que explorem como estas ferramentas podem fomentar a discussão projetual entre os agentes envolvidos e permitir a realização de alterações em tempo real em um processo colaborativo. O objetivo deste artigo é verificar o potencial de ferramentas de interação disponíveis em um programa que permite a realização de atividades no ambiente virtual imersivo a partir de uma modelagem BIM. Um estudo piloto foi realizado com três arquitetos que possuem ampla experiência em escritórios de projeto de Arquitetura, para discutir as potencialidades e as limitações deste processo. Foram desenvolvidas simulações e aplicado um protocolo de entrevistas. Dessa forma, buscou-se identificar como pode ocorrer a sua aplicabilidade em um processo colaborativo envolvendo arquitetos, projetistas de outras especialidades e os usuários/clientes. Os resultados indicam um bom potencial para o uso das ferramentas em diversos aspectos do processo de projeto.
O uso das simulações virtuais imersivas como auxílio na captura de diretrizes projetuais
Authors: Mandola Juliana Bambini , Durante Amanda Leticia Passolongo , Padula Poliana , Oliveira Vivian Maria Amaral de , Azuma Maurício Hidemi , Imai César
Published: October 2023

Dentre as diversas inovações digitais existentes para a discussão do projeto em AEC, o uso de ferramentas tecnológicas imersivas tem se destacado em ambientes colaborativos por auxiliar na captação de requisitos e diretrizes de projeto a partir da colaboração dos usuários finais. O objetivo deste artigo é explorar o potencial de uma ferramenta virtual imersiva para coleta de dados em conjunto com os usuários finais a partir do uso de celulares e dos óculos de Realidade Virtual. Foram realizadas simulações com a participação de usuários de uma biblioteca setorial para avaliar o projeto da nova Biblioteca Central da Universidade Estadual de Londrina, com foco em análises de percepção da circulação, dimensionamento, iluminação e mobiliário. Como resultado, foi possível identificar os requisitos mais importantes para os usuários e propor modificações no projeto da nova biblioteca, evidenciando que a ferramenta possui grande potencial como facilitador no processo de compreensão dos detalhes arquitetônicos.
Projeto participativo no desenvolvimento de uma habitação modelo para populações ribeirinhas do Pantanal
Authors: Pasello Bruno José Olivari , Moura Jorge Daniel de Melo , Imai César , Mandola Juliana Bambini , Graton Fernando Gargantini
Published: October 2023

A vulnerabilidade habitacional é um problema existente há diversos anos nas regiões ribeirinhas do Pantanal, resultante das intempéries climáticas extremas, que expõem os habitantes a riscos de acidentes, desmoronamentos e contaminações ambientais. Diante deste cenário, uma Organização Não Governamental (ONG) que atende a região constituiu um grupo de arquitetos voluntários para conceber uma habitação adaptada ao contexto natural da região. O projeto foi realizado de maneira participativa, com a plena inclusão da comunidade local. Apresentações, entrevistas, questionários, levantamentos físicos e observações foram adotados com o objetivo de identificar de forma abrangente os problemas enfrentados pela comunidade. Por meio de um estudo de caso realizado na comunidade da Barra do São Lourenço, o presente artigo tem como propósito mapear os problemas identificados durante a pesquisa de campo e propor diretrizes gerais que possam contribuir para o desenvolvimento de futuros empreendimentos habitacionais em áreas remotas do Pantanal.
BIM para gestão da manutenção em prédios públicos
Authors: Wojciechowski Anderson Martins , Schramm Fábio Kellermann , Bortolini Rafaela
Published: October 2023

A manutenção adequada do ambiente construído desempenha um papel essencial na conservação, durabilidade e funcionalidade das edificações. Para prédios públicos, uma gestão eficiente da manutenção é crucial para garantir a segurança dos ocupantes e valorizar o patrimônio imobiliário. No entanto, os desafios enfrentados nessa gestão, como a falta de dados atualizados, complexidade das instalações e restrições orçamentárias, impulsionam a busca por soluções mais eficientes de apoio à tomada de decisão. Nesse contexto, a Modelagem da Informação da Construção (BIM) surge como uma ferramenta promissora, oferecendo um repositório centralizado de informações vinculadas a um modelo digital da edificação. Este estudo tem como objetivo compreender as práticas, políticas, hábitos e processos adotados na gestão da manutenção em edificações públicas, bem como a maturidade da aplicação do BIM nesse contexto. Um questionário foi aplicado a servidores públicos responsáveis pela operação e manutenção de imóveis em uma Instituição Federal de Ensino Superior, visando obter uma compreensão mais aprofundada desses processos. Os resultados indicam que o uso do BIM ainda não é uma realidade implementada.
Avaliação acústica de um cânion urbano
Authors: Antonio dos Santos Marcos Vinicius , Rezende Laura Moreira , Barbosa Sabrina Andrade , Drach Patrícia Regina Chaves
Published: October 2023

O planejamento acústico de áreas urbanas, apesar de impactar significativamente a saúde da população, ainda não recebe atenção suficiente. As ruas-cânion trazem preocupações pois se trata de uma configuração morfológica em que a verticalização dos edifícios enfileirados ao longo de ambos os lados pode inibir o espraiamento dos raios sonoros. Assim, o objetivo deste trabalho é avaliar as condições acústicas de um cânion urbano. Medições in loco durante a semana e finais de semana, nos períodos da tarde e noite, foram realizadas e comparadas em duas ruas na cidade de Petrópolis - RJ: a rua-cânion 16 de Março e a larga rua do Imperador. Os resultados indicaram que nenhum dos pontos de medição apresentaram níveis de pressão sonora dentro dos limites indicados por normativa nacional, demonstrando que o nível de ruído no meio urbano em Petrópolis é excessivo. Na rua-cânion, embora prioritariamente para pedestre, a alta verticalização possivelmente resultou em múltiplas reflexões sonoras entre fachadas, limitando o espraiamento dos raios e contribuindo para o aumento dos níveis sonoros. Assim, apesar das distintas relações de altura e largura das ruas e das diferenças em relação à geometria das edificações, os usos e fluxos foram determinantes nas diferenças de ruído entre as ruas.
Discorrendo sobre o método de projeto: caso da sede da Amparho
Authors: Cunha Amanda Garcia da , Cunha Eduardo Grala da , Fernandes Livia Winkel , Oliveira Luciele dos Santos , Lourenço Nátalin Pucinelli , Lima Danielle , Gattiboni Maria Elisa , Bandeira Dara Elisa dos Santos , Cordeiro Camila Santos , Portella Adriana Araujo
Published: October 2023

Este artigo apresenta um Estudo Preliminar da Sede da Associação Amparho a ser construída na cidade de Pelotas sob a ótica do método de projeto. Tem como objetivo apresentar um exemplo prático da atividade de desenvolvimento de um projeto de arquitetura com a participação de acadêmicos extensonistas durante o processo. Com relação ao método, o processo de trabalho é dividido em três etapas. Na primeira etapa o desafio de projeto foi conceituado, observando o Quaterno Contemporâneo de Mahfuz (2004), no qual o desafio de projeto é trabalhado sobre três enfoques vinculados ao problema de projeto – lugar, programa e técnica, e um quarto voltada à Teoria da Arquitetura – Estrutura formal. Na segunda etapa da pesquisa foi realizado um estudo de massas e um estudo de manchas, zoneamento e estudo de volumetria em consonância com o conceito de projeto. Na terceira e última etapa é lançado o estudo preliminar. Como resultados do trabalho destaca-se o caráter didático da proposta de desenvolvimento do projeto de arquitetura como exercício de aprendizado para um grupo de alunos de Graduação que estão participando do projeto de Extensão.
A qualidade arquitetônica em habitações de interesse social: um estudo de caso sobre a privacidade
Authors: Rodrigues Raissa Silva , Silva Heitor de Andrade
Published: October 2023

O artigo tem o objetivo de analisar a privacidade em unidades habitacionais de interesse social, localizadas na Região Metropolitana de João Pessoa, Paraíba. Adota o método de Definição e Avaliação da Qualidade Arquitetônica Habitacional. Trata-se de um método de análise gráfica de projeto, que adota uma avaliação por multicritérios das exigências de qualidade habitacional em diferentes níveis. Os resultados revelam que, considerando os parâmetros adotados, das seis unidades habitacionais analisadas uma apresentou um bom desempenho, se destacando com relação às demais e duas atingiram desempenho insatisfatórios. De modo geral, observou-se que os espaços de transição (circulação) entre as áreas íntima, social e de serviço, bem como a disposição espacial (setorização) desempenham um papel determinante no nível de privacidade das unidades, aliado a outras estratégias de projeto, que objetivam a redução dos impactos provocados pela falta de privacidade na unidade habitacional. Por fim, o artigo ressalta a importância relativa da privacidade em Habitação de Interesse Social, considerando o contexto sociocultural em que as unidades estão inseridas, bem como a pertinência e os limites do método de análise gráfica de projeto utilizado.
A review on investigating the blurring thought to be experienced in cognitive functions during pregnancy
Authors: UYSAL CANTÜRK Pınar
Published: October 2023

Hamile bireyler arasında genellikle "hamilelik beyni" olarak adlandırılan unutkanlık ve zihinsel bulanıklık gibi
yaygın bir deneyim vardır. Ancak, bu olgunun gerçek olup
olmadığı sorusu belirsizliğini koruyor. Hamilelik, bir kadının vücudunda önemli hormonal ve fizyolojik değişiklikleri içeren benzersiz bir fizyolojik süreçtir. Hamilelik
sırasındaki fiziksel dönüşümler iyi belgelenmiş olsa da, bu
dönemde meydana gelebilecek olası bilişsel değişiklikleri
araştırmaya ilgi artmaktadır. Bu çalışma, gebeliğe bağlı bilişsel bozulma ile ilgili mevcut literatürü keşfetmeyi ve bu
alandaki mevcut anlayışa genel bir bakış sunmayı amaçlamaktadır
Hizmetkâr Liderlik Üzerine Bir Değerlendirme: Hayat Bugün Dizisi Örneği
Authors: ÇELEBİ Muhammet Ali
Published: October 2023

Amaç: Yönetim alanında teoriyi pratiğe bağlamak için popüler
kültürün (özellikle sinema, dizi vb.) araçları kullanılmaktadır. Popüler kültür ilgi çekici ve eğitici bir deneyim sunarak yönetimle
ilgili birçok konunun anlaşılmasında yöneticilere, çalışanlara, öğrencilere ve öğretim üyelerine destek sağlamaktadır.
Yöntem: Bu kapsamda bir televizyon programı olan Hayat Bugün dizisi hizmetkar liderliğin anlaşılması için bu çalışmada incelenmiştir. Dizideki başrolü üstlenen Başhekimin tutum ve davranışları ve çalışanları ile ilişkileri Greenleaf ve Spears’ın Hizmetkar
Liderlik Modeli (1) kapsamında oluşturulan on tema kapsamında ele alınmıştır.
Bulgular: Araştırma yöntemi olarak nitel araştırma yönteminin
benimsendiği çalışmada betimsel analiz tekniği tercih edilmiştir.
Sonuç: Analiz sonucunda dinleme, empati, iyileştirme, farkındalık, ikna, kavramsallaştırma, öngörü, hizmet odaklılık, kişilerin
büyümesine/gelişmesine bağlılık, topluluk kurma temalarının
dizide işlendiği sonucuna ulaşılmıştır
Increased Graduation Rates in Students Who Take One or More Experiential Learning Classes during Their Undergraduate Program of Study
Authors: Rost Jim , Swayze Anita Carol , Janet McCormick
Published: October 2023

A large American university in the southeastern United States has infused experiential learning into academic courses to create a national model that is both sustainable and replicable. The EXL Scholars Program has consistently shown growth and significant positive outcomes by providing students with opportunities for hands-on experiences in their fields of study, service learning opportunities, valuable networking with professionals, and an opportunity to explore career paths through real-world activities. Student learning assessments provide evidence that the EXL Scholars Program has a positive benefit for students and does enhance students’ learning experiences as stated in the program’s motto, EXL: Experience the Advantage.  This article will explore how the program has been institutionalized and how students who participate in the Experiential Learning Scholars Program graduate at a significantly higher rate than those students who do not.
Exploring the Transformative Effects of Service-Immersion Programs on Faculty
Authors: Clark Richard , Menkhaus James , McGinnness Anne , Sutterluety Megan
Published: October 2023

Service-immersion programs are prevalent at many universities, often housed in ministry, mission, or service-learning departments. These experiences vary from domestic to international exploration, often lasting five to twelve days. Unlike study abroad programs that usually last a semester, service immersion “trips” are shorter and often include some sort of community service component. Current scholarship in experiential learning has focused on the influence of service immersion programming on undergraduate students. What is missing from this literature is the effect of immersion participation on adult accompaniers such as faculty. Since these adults share the same basic experience as the students, they may experience some of the transformative development as their students. Using Mezirow’s Transformative Learning Theory, as our guide, we explored three areas of transformative development  – the influence of the immersion experience on faculty themselves, how the experience affected the faculty members’ relationships with students, and how the experience affected classroom instruction. The results were positive as the participating faculty reported positive personal growth, a deeper understanding of their students, and an enhanced learning environment that included the classroom as well as additional opportunities such as mentoring.
Promoting Student Success and DE&I in Experiential Education at an HBCU: STEM Lab Internship Programs
Authors: Perchiniak Erin , Fees Joseph , Silver Alexa
Published: October 2023

Over the past four years, a Howard Hughes Medical Institute (HHMI) Inclusive Excellence grant supported Delaware State University (DSU) to increase student success and foster faculty development in the STEM (Science, Technology, Engineering, and Mathematics) fields. One component of this grant has provided students, particularly early sequence (freshman and sophomores), the opportunity to participate in a lab internship program. This program has provided students with access to vital research experience and removed some of the barriers for student opportunities, particularly for minority and first-generation students, in STEM fields.  The internship program is rooted in principles of diversity, equity, and inclusion and is a cost-effective model for increasing experiential opportunities for STEM students.  This paper will share the logistics and inclusive parameters of the program, survey data from student and faculty mentors, as well as highlight the benefits of incorporating an early experiential learning opportunity for students in STEM fields.  The paper demonstrates the steps to create a low-cost lab program and how future internships experiences can be designed with diversity, equity, and inclusion as core principles.
Educational Equity: Study Abroad for Underrepresented Minority and First-Gen Public Health Students
Authors: Sharma Archana More
Published: October 2023

For public health students, global education supports development of core skills towards becoming effective leaders and advocates for health equity. Despite the growing number of undergraduate students participating in experiential study abroad opportunities, there remains a stark educational disparity: racial and ethnic minority students continue to be underrepresented. Less than 20% of Hispanic/Latinx and African American students participate in study abroad (NAFSA, 2022). This situation is especially urgent given the shortage of diverse public health professionals. It is imperative for the educational pipeline to address the structural limitations that hinder access to academic opportunities for diverse and disadvantaged students. To meet the challenge, our institution created a course expressly for underrepresented minorities and first-generation public health students. This article describes the course’s intentional design, implementation, and assessment of long-term outcomes. Findings highlight the impact of this experience for minority and first-gen students as they entered graduate education and the public health workforce. All participants voiced benefits in developing relevant career skills, global citizenship, and personal growth. As public health educators, our focus on health equity must include equitable access to innovative experiences for underserved public health students as fundamental to public health pedagogy.
Note from the Editor
Authors: O'Donnell Ken
Published: October 2023

Note from the Editor
UV-blocking sustainable food packaging based on polyhydroxyalkanoate and bacterial pigment prodigiosin
Authors:   University of Belgrade, Institute of Molecular Genetics and Genetic Engineering, Serbia, Ponjavic Marijana , Malagurski Ivana ,   University of Belgrade, Institute of Molecular Genetics and Genetic Engineering, Serbia, Salevic-Jelic Ana ,   University of Belgrade, Faculty of Agriculture, Department of Food Technology and Biochemistry, Serbia, Lazic Jelena ,   University of Belgrade, Institute of Molecular Genetics and Genetic Engineering, Serbia, Nikodinovic-Runic Jasmina ,   University of Belgrade, Institute of Molecular Genetics and Genetic Engineering, Serbia
Published: October 2023

New film materials based on bacterial biomolecules polyhydroxyalkanoate (poly(3-hydroxybutyrate-co-3-hydroxyvalerate) PHBV) and prodigiosin (PG) were produced by solvent casting as a potential food packaging material. Film precursors were obtained in a sustainable manner via microbial fermentation using waste stream-based substrates (cooking oil and second-grade canned meat, after the expiry date). The incorporation of PG into the PHBV has influenced the morphology and functionality of the obtained materials. PG acted as a nucleating agent, affecting in turn PHBV/PG film surface morphology. The films were intensively colored, transparent and blocked UV-light. An increase in PG content decreased film transparency but it did not affect UV-blocking ability. Migration experiments have shown that films possess the potential to release PG into lipophilic food simulant media where it has exhibited antioxidative action. The obtained results suggest that PHBV/PG films can be potentially used as sustainable and active food packaging materials.
Using numerical modeling to analyze the behavior of cancer cells after diverse co-treatments
Authors:   University of Kragujevac, Institute for Information Technologies, Serbia, Djukić Tijana , Seklić Dragana ,   University of Kragujevac, Institute for Information Technologies, Serbia, Jovanović Milena ,   University of Kragujevac, Institute for Information Technologies, Serbia, Zivanović Marko ,   University of Kragujevac, Institute for Information Technologies, Serbia, Filipovic Nenad ,   University of Kragujevac, Faculty of Engineering, Serbia
Published: October 2023

It is important to analyze a variety of treatments for colorectal cancer and the effects of possible co-treatments, in order to find the most efficient ones. Experimental results using cancer cell lines provide valuable information, but in combination with numerical simulations, additional quantitative information can be obtained. In this study, the viability of SW-480 cancer cells was analyzed experimentally after cotreatments of Phellnus linteus extract and chemical compound (Cisplatin drug). Numerical simulations are afterward applied to analyze the effect of diverse cotreatments on the numerical parameters of the model that are related to both cell proliferation and cell death. This approach can provide valuable insight into the quantitative effect these considered treatments have on the behavior of cancer cell lines. Similar analyses could be also performed using numerical simulations to predict the values of parameters for diverse cases that were not studied experimentally, and this would be an additional benefit for the exploration of the effects of various possible treatments.
Multiscale Modelling of the Effects of Temperature on Cardiac Twitches
Authors:   University of Kragujevac, Institute for Information Technologies, Serbia, Prodanovic Momcilo , Mijailovich Srboljub M. ,   FilamenTech, Inc., Newton, USA
Published: October 2023

Functional changes in cardiac muscle, caused by mutations in sarcomere proteins, are significant for understanding cardiac pathophysiology. Experimental investigations of mechanical responses in cardiac tissue, especially in humans, are limited due to challenges in obtaining suitable samples. Trabeculae from transgenic rodent models serve as a common experimental model for studying cardiac function. However, differences in temperature between experimental settings and physiological conditions, as well as differences in myosin α and β isoform content, can complicate the interpretation and translation of findings from rodents to humans. To bridge this gap, we present a novel methodology utilizing the MUSICO computational simulation platform for multiscale modeling of cardiac twitch contractions. MUSICO integrates crossbridge cycling, calcium regulation of thin and thick filaments, explicit 3D sarcomere geometry, and species-specific mixtures of myosin isoforms. In this study, we quantitatively estimated the impact of temperature variations on twitch transients in rat trabeculae using MUSICO simulations. Model predictions were compared with a consistent set of experimental data from rat trabeculae. Our results demonstrated that the temperature of the experiments plays a significant role in force generation during cardiac muscle twitch, since it affects intracellular calcium concentrations, but also influences several crossbridge cycle kinetic rates which had to be adjusted in simulations for accurate predictions of twitch responses. By accounting for species-specific physiological variations and the temperature sensitivity of cardiac responses, this approach offers insights into a more comprehensive understanding of cardiac dynamics, ultimately leading to the prediction of human cardiac muscle responses under physiological conditions. Through improved predictive capabilities, MUSICO will open new opportunities for the development of novel therapeutics and treatments targeting cardiomyopathies.
Analytically Computed Fractional Flow Reserve based on Coronary CT Angiography
Authors:   University of Kragujevac, Institute for Information Technologies, Serbia, Milovanović Aleksandar , Isailović Velibor ,   University of Kragujevac, Faculty of Engineering, Serbia, Saveljić Igor ,   University of Kragujevac, Institute for Information Technologies, Serbia, Filipović Nenad ,   University of Kragujevac, Faculty of Engineering, Serbia
Published: October 2023

Invasively determined Fractional Flow Reserve (FFR) has been recognized as a reliable tool for assessing coronary artery stenosis severity. Since the invasive method is associated with a risk of vessel injury due to pressure wire manipulation several non-invasive techniques have been developed. The objective of this paper is to propose an alternative, much less time-consuming, analytical solution based on Computed Tomography Angiography (CTA) images and the overall pressure drop calculation across the stenosis in the coronary artery. The results obtained using this method are validated by comparing them with the clinical data for patients who underwent invasive coronary angiography as well as with the results obtained by using CFD simulation. FFR determined using the analytical method compared with the clinical and CFD ones differs by 4.5% and 3.9% respectively. This confirms that the analytically determined FFR can be reliable for the physiological assessment of coronary artery stenosis.
Application of Machine Learning Algorithms in Medical Data Processing
Authors:   University of Kragujevac, Faculty of Engineering, Serbia, Geroski Tijana , Filipović Nenad ,   University of Kragujevac, Faculty of Engineering, Serbia
Published: October 2023

Machine learning (ML) leverages sophisticated computation and inference to generate insights, enables the system to reason and learn, and empowers clinician decision making. Starting from data (medical images, biomarkers, patients’ data) and using powerful tools such as convolutional neural networks, classification and regression models, etc., it aims at creating personalized models, adapted to each patient, which can be applied in real clinical practice as a decision support system to doctors.
Structural, spectroscopic, and molecular docking analysis of isoproterenol
Authors:   University of Belgrade, Faculty of Physical Chemistry, Belgrade, Serbia, Milosavljević Marija , Rakić Aleksandra ,   University of Belgrade, Faculty of Physical Chemistry, Belgrade, Serbia, Dimić Dušan ,   University of Belgrade, Faculty of Physical Chemistry, Belgrade, Serbia
Published: October 2023

Isoproterenol (ISO) is a non-selective β adrenoceptor agonist structurally similar to epinephrine and norepinephrine. In this contribution, the structure of ISO was optimized by several common functionals (B3LYP, CAM-B3LYP, B3PW91, M06-2X, and M05-2X) in conjunction with 6-311++G(d,p) level of theory. The appropriate level of theory (M05-2X/6-311++G(d,p)) was determined by a comparison between experimental bond lengths and angles. The experimental and theoretical IR spectra were obtained, and a high resemblance between them was observed, with the positions of the most intense bands being well reproduced. The differences in these values were explained by the physical state of a sample that was used for the experimental spectra. The experimental and theoretical wavenumbers of the most prominent transition in UV- Vis spectra were very similar, and this transition was assigned as HOMO→LUMO. The scavenging activity towards DPPH was determined by UV-Vis spectroscopy. The antiradical potency of ISO was comparable to standard antioxidants due to the presence of catechol moiety. These structural parameters were also important for the interactions of β1 adrenergic receptors.
Molecular docking study of ruthenium-p-cymene complexes with isothiazole derivatives as SARS-CoV-2 main protease inhibitors
Authors:   University of Kragujevac, Faculty of Science, Serbia, Radovanović Marko , Filipović Ignjat ,   University of Kragujevac, Faculty of Science, Serbia, Đukić Maja ,   University of Kragujevac, Faculty of Science, Serbia, Ristić Marija ,   University of Kragujevac, Faculty of Science, Serbia, Jakovljević Ivan ,   University of Kragujevac, Faculty of Science, Serbia, Matović Zoran D. ,   University of Kragujevac, Faculty of Science, Serbia
Published: October 2023

Since proper treatment for COVID-19 still has not been developed, exploration of novel options is required. Activities of different metal complexes, promising results gained from examining different thiazole derivatives, and research in the field of natural products like p-cymene, produced an idea to test piano stool ruthenium p-cymene complexes with isothiazole derivatives as ligands. In silico methods are often used as the first step in a series of experiments during the development of new drugs, and docking simulations are a quick way to determine the feasibility of novel compounds as potential inhibitors of target enzymes. Existing compounds of ruthenium with published crystal structures were tested against the main protease of SARS-CoV-2. All of the tested compounds show a potential ability to bind to the target enzyme, while the compound with phenyl and morpholinyl substituents in isothiazole ligand shows the best activity among tested compounds. Authors feel confident that further research on this topic will yield compounds with even better potential activities against the main protease of the SARS-CoV-2.
The Influence Of Price, Location And Promotion On Customer Loyalty Mediated By Customer Satisfaction
Authors: Ing Ing , Dahlan Kandi Sofia S.
Published: October 2023

The discussion regarding the role of hotel management towards guests who come to visit to feel satisfied with the services provided and have the desire to visit again at Grand Cordela Hotel Bandung. Hotel management will find ways to attract new prospective customers by providing promotions and events/events so that potential customers are interested and become loyal customers to the Grand Cordela Hotel Bandung. The purpose of this study was to determine and analyze the effect of price, location, and promotion on customer loyalty which is influenced by customer satisfaction, which is at Grand Cordela Hotel Bandung under the operation of Omega Hotel Management - PT Perkasa Internusa Mandiri. The sample of this study used the entire population of guests staying at the Grand Cordela Hotel, Bandung. This research uses correlational quantitative methods and uses Structural Equation Models (SEM). For data processing this research uses the SmartPLS version 4.0 programme. The results of the questionnaire on 34 indicators with a total of 197 respondents were collected after checking and then proceeding with data processing, the results were 5 invalid indicators so the total valid indicators amounted to 29 (twenty-nine) indicators. In this study, there are 10 (ten) hypotheses but after data management, there is 1 (one) hypothesis that is rejected and 9 (nine) other hypotheses are accepted, namely location, promotion, and customer satisfaction have a positive and significant effect on customer loyalty, and price, location, promotion has a positive and significant effect on customer satisfaction and price, location, promotion has a positive and significant effect on customer loyalty mediated by customer satisfaction.
Analisis dan Perbaikan Sistem Kompensasi pada UKM XYZ Kota Cilegon dengan Metode Dua Titik
Authors: Naufaldy Rahman Edly , Putri Pertiwi Hana , Nurlaila Hasna Najmah , Uhastaning Kinasih Zahra , Kartika Lindawati
Published: October 2023

Every company has an obligation to provide wages to employees in accordance with the provisions. The provision of wages according to the standard aims to ensure that workers earn an income that can meet the needs of a decent life. The compensation system is considered important in an organization because it has a direct impact on employee motivation and performance. This study aims to assess the compensation system in UKM XYZ in Cilegon City, which is engaged in the culinary sector, and provide recommendations for improving the compensation system. The methods used in this study are determining job value based on compensation factors using the Hay method, determining job grading using the given grade and minimum maximum methods, and salary mapping using the two-point method. The results obtained from this study indicate that the compensation system in the form of salary at UKM XYZ is still not ideal because it is below the minimum wage and there is no job grading determination yet. There are ten compensable factors needed in determining the compensation system for UKM XYZ. Improvements were made by calculating job values and dividing job titles into four grades. Based on salary mapping for a more ideal compensation system, the results show that salary mapping using the two-point method can be considered by SMEs for future implementation because it already meets the minimum wage and is adjusted to the budget of UKM XYZ.