bluuebunny/crossref_metadata_2025 huggingface dataset:
“Liikumisega” vene laulude kultuurilisi tähendusi Udmurdimaa Debjossõ rajooni Varni külas
Authors:   Udmurt Institute of History, Language and Literature, UdmFRC UB RAS, Izhevsk, Russia, Tolkachova Svetlana
Published: December 2024

The aim of this article is to identify the specific features of the functioning of Russian round dance and dance songs in the traditional culture of the Northern Udmurts. Four songs in Russian, recorded from Udmurt performers by Tatiana Vladykina in the village of Varni, Debessky district of Udmurtia, in 1981 were chosen for the study: “My zaganem sem’ zagadok”, “Pri dolinke voda”, “…Tropitsa, kanapel’kalotitsa”, “Chornyi voron vodu pil”. The correlation of these songs with Russian songs of the round dance tradition in the Kama-Vyatka interfluve allows classifying them as “songs with movement”.
The analysis of the musical and poetic stylistics of the songs and the cultural context of their performance reveals that in Udmurt folklore, Russian round dance and dance songs exist parallel to the well-established core of sacral clan chants specific to the Udmurts. At the same time, a trend of assimilating Russian “songs with movement” has emerged in the traditional musical culture of the Northern Udmurts, to the extent that some of them have acquired a sacral meaning.
These trends in the existence of round dance and dance songs in Russian in the Northern Udmurt dialect traditions are linked to a collective, unifying element, the festive atmosphere, and the perception of Russian round dance songs as a “borderline” genre. Yet another trend applies to the practice of performing round dance songs at a slow tempo. For the performance of these songs, singers demonstrate a more personal approach to the reproduced sonic fabric, expressing their individuality and uniqueness at the sound level. The singing of some slow Russian round dance songs by the Northern Udmurts turns out to be consonant with the performances of krezes in terms of musical-rhythmic parameters.
The third tendency, the incorporation of slow round dance songs with Russian lyrics into Udmurt rituals, is also connected with the inherent possibility of endowing the sound canvases of such songs with “special” timbral, acoustic, and metric-rhythmic qualities characteristic of indigenous Udmurt ritual songs and “harmonious” with the musical expression of Udmurt rituals.
Artificial Intelligence and Information Governance: Strengthening Global Security, through Compliance Frameworks, and Data Security
Authors: Kolade Titilayo Modupe , Aideyan Nsidibe Taiwo , Oyekunle Seun Michael , Ogungbemi Olumide Samuel , Dapo-Oyewole Dooshima Louisa , Olaniyi Oluwaseun Oladeji
Published: December 2024

This study examines the dual role of artificial intelligence (AI) in advancing and challenging global information governance and data security. By leveraging methodologies such as Hierarchical Cluster Analysis (HCA), Principal Component Analysis (PCA), Structural Equation Modeling (SEM), and Multi-Criteria Decision Analysis (MCDA), the study investigates AI-specific vulnerabilities, governance gaps, and the effectiveness of compliance frameworks. Data from the MITRE ATT&CK Framework, AI Incident Database, Global Cybersecurity Index (GCI), and National Vulnerability Database (NVD) form the empirical foundation for this analysis. Key findings reveal that AI-driven data breaches exhibit the highest regulatory scores (0.72) and dependency levels (0.81), underscoring the critical need for robust compliance frameworks in high-risk AI environments. PCA identifies regulatory gaps (45.3% variance) and AI technology type (30.2% variance) as significant factors influencing security outcomes. SEM highlights governance strength as a primary determinant of security effectiveness (coefficient = 0.68, p < 0.001), while MCDA underscores the importance of adaptability in governance frameworks for addressing AI-specific threats. The study recommends adopting quantum-resistant encryption, enhancing international cooperation, and integrating AI automation with human oversight to fortify governance structures. These insights provide actionable strategies for policymakers, industry leaders, and researchers to navigate the complexities of AI governance and align technological advancements with ethical and security imperatives in a rapidly evolving digital landscape.
Clinical pearls for the management of duloxetine patients with medical comorbidities
Authors: O’Connell Megan , VandenBerg Amy
Published: December 2024

The effective use of duloxetine can be complicated by acute kidney injury, acute and/or chronic hepatic dysfunction, dysphagia, enteral nutrition, and common pharmacokinetic interactions. This article aimed to review the pharmacological properties of duloxetine pertinent to its use and to discuss the management of duloxetine in patients with common acute and chronic medical comorbidities. Management strategies based on clinical data and expert opinion are reviewed in 3 patient cases.
Exploring the Potential of Blockchain Technology in Digital Tax Administration to Enhance Tax Compliance
Authors: Mangoting Yenni , Widuri Retnaningtyas , Dogi Dean Charlos Padji , Gabronino Rosalia
Published: December 2024

This research seeks to enhance the technology acceptance model (TAM) by examining cognitive belief factors, specifically the influence of perceived usefulness and perceived ease of use, on taxpayers' intentions to utilize blockchain technology. This investigation explores both the direct and indirect effects of perceived enjoyment. This research also examined the impact of behaviour, specifically the trust factor, on perceived usefulness and perceived ease of use. We extended the TAM by assessing the mediating influences of the perceived enjoyment factor. The research employs a survey methodology. We collected data from 213 individual taxpayers. However, we were only able to process the data of 155 respondents. Questionnaires serve as a valuable tool for gathering data through Google Forms. We analysed the data using PLS-SEM. The research findings indicate that there is a form of mediation where the perceived usefulness of blockchain technology has a notable impact on taxpayers' intentions to use it, either directly or through the perceived enjoyment it brings. Perceived enjoyment also mediates the influence of perceived ease of use on taxpayers' intentions to use blockchain. Moreover, taxpayer trust has effectively influenced taxpayers' perceptions that technology is user-friendly and advantageous. To improve the level of service provided to taxpayers, tax authorities must leverage the advancements of the information technology era. The research findings make a valuable contribution to the tax authorities' readiness to adopt a blockchain-based tax administration system. The results highlight the significance of the authority's efforts to enhance taxpayers' intrinsic motivation when using tax information technology. Creating a user-friendly and enjoyable experience that brings joy, excitement, and comfort can achieve this.
Paylater as The Millennial Payment: Theory Planned Behavior
Authors: Fatmawati Susan , Suwardi Eko
Published: December 2024

This study aims to identify the motivations of Millennials who use Paylater services as a payment method in transactions and then investigates their perceptions and financial control regarding the risk of Paylater through the theory of planned behavior. This research involves individuals from the Millennial generation who have used Paylater services, using a qualitative approach through interviews. Primary data in the form of interviews in this study uses thematic analysis, by collecting and analyzing data, coding data, developing analytical ideas and concepts, and connecting analysis with the theory used. The results revealed that the ease of access, flexibility, and promo incentives of Paylater motivate Millennials to use it. Social pressure from relatives, the environment, and social media influences this motivation, along with their belief in their control over Paylater. However, Millennials also perceive risks such as spontaneous purchases, financial difficulties, and default, which raises doubts about using this service. These findings highlight the importance of considering psychological aspects, financial literacy, and financial behavior in using Paylater responsibly.
Sonochemically Modified Lapindo Mud Using Sulfuric Acid for Efficient Adsorption of Phenol in Aqueous Media and Real Wastewater Samples
Authors: Wijaya Karna , Bhagaskara Adyatma , Sani Maria Francia Mirabella , Vebryana Marini Fairuz , Pratama Fernando Alvaro , Anggraeni Widuri , Amin Amalia Kurnia , Ramadhani Faturrahman Al , Saviola Aldino Javier
Published: December 2024

Pharmaceutical industrial wastewater frequently contains high amounts of phenolic substances, which pose severe threats to the ecosystem and human health. Therefore, efficient removal of these pollutants is urgently needed. In the present work, sulfated Lapindo mud (SLM) was prepared using the sonochemical method and applied as an adsorbent for phenol removal in aqueous media and actual wastewater samples from Code River, Yogyakarta. Modification of Lapindo mud (LM) using sulfuric acid enables it to remove its impurities, resulting in a material containing 78.4% silica (SiO2) and 15.3% alumina (Al2O3). The SLM adsorbent demonstrated sufficient adsorption performance of 49.8% with an optimal initial phenol concentration of 120 mg/L with a contact time of 100 min at pH of 10. The maximum adsorption capacity (qmax) obtained by the Langmuir isotherm model was 27.2 mg/g. The adsorption process follows pseudo-second-order because it has two active sites, Brønsted acid sites (–SiOH and –SO3H) and Lewis acid sites (Si4+). Phenol in base condition undergoes a deprotonation reaction that is stabilized by the acid-active sites of the SLM adsorbent through intermolecular forces. Considering the large adsorption capacity and quick kinetic, the SLM adsorbent can be a promising cheap and green material to remove phenolic substances in wastewater, especially in the river near the medical facility. Copyright © 2024 by Authors, Published by BCREC Publishing Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0).
INTERVENÇÕES SOCIOESPACIAIS NO BAIXO CURSO DA BACIA HIDROGRÁFICA DO RIO ITACANOEIRA (BHRI) – ILHÉUS/BA.
Authors: Silva Emilson , Puentes Antonio , Gonçalves Mário Jorge de Souza
Published: December 2024

As bacias hidrográficas se constituem em uma importante área de estudo para mensurar as intervenções socioespaciais. Assim, esta pesquisa teve como dimensão espacial a bacia hidrográfica do rio Itacanoeira, que fica localizada ao norte do município de Ilhéus/BA. O objetivo foi produzir material cartográfico da bacia, bem como identificar as principais intervenções socioespaciais no seu baixo curso. O material cartográfico foi produzido a partir de imagens de satélite do CIBERS, fornecidas pelo INPE e de shapefiles fornecidos pelo IBGE, que, a partir do Quantum GIS, serviram de base para a delimitação da bacia e constituição da rede de drenagem. Também foi realizado registro fotográfico. Além da produção do mapa da área, os dados permitiram concluir que ao longo da Rua do Mosquito e Avenida Princesa Isabel e bairros do Jardim Savóia e Teotônio Vilela, ocorre o lançamento de esgotos domésticos e aterro de áreas de mangues.
MUDANÇA DE NÍVEIS DE ÁGUA (1995-2021) NO ESTUÁRIO SUPERIOR DO RIO AMAZONAS (BAIXO AMAZONAS - PARÁ): POSSÍVEIS FATORES CLIMÁTICOS
Authors: SAMPAIO RAFAELE
Published: December 2024

Este artigo analisa as condicionantes hidrometeorológicas no Baixo Amazonas, determinando as variabilidades temporais e espaciais dos aspectos meteorológicos, hidrológicos, anomalias ENOS, aliados a análise de tendências através do teste não paramétrico de Mann-Kendall. Nos anos de 1997-1998, o El Niño de forte intensidade impactou na diminuição da cota do rio (3,06 m) em 1998, na vazão (72469,31 m³/s) em 1997. Em 1995-1996 o El Niño moderado causou a diminuição das cotas (2,67 m em 1995 - menor da série histórica). Em 2007-2008, La Niña moderado atuou no regime pluviométrico (2008 teve o maior índice de toda a série histórica - 825,10 mm). Em 2020-2021, La Niña de moderada intensidade elevou a cota fluviométrica a 5,75 m (2021) e na cheia atingiu vazão de 273143,34 m³/s (maior da série histórica). Foi atestada pelos métodos estatísticos que ocorreram tendências positivas na vazão e no nível do rio e estacionariedade dos dados pluviométricos.
GEOANÁLISE EM BACIA HIDROGRÁFICA PARA DEFINIÇÃO DE REGIÕES HOMOGÊNEAS
Authors: Teixeira Marcilio Baltazar , Camargo Pedro Luiz Teixeira de , Martins Junior Paulo Pereira
Published: December 2024

A caracterização apresentada neste estudo buscou identificar e cartografar os diferentes tipos de unidades pedo-mórfico-litográficas encontradas numa bacia hidrográfica do médio alto São Francisco, localizada no norte de Minas Gerais. Foi possível gerar uma panorâmica geral da grande geodiversidade, o que permitiu uma visualização da distribuição espacial das principais classes temáticas e forneceu informações importantes para diversos fins, como ensino, pesquisa e extensão. Este trabalho também descreveu uma técnica para levantamento e diagnóstico de áreas homogêneas considerando os aspectos e as características pedo-mórfico-litográficos encontrados. Com a análise, foi possível observar que existem “geo-relações” evidentes entre algumas áreas, o que permitiu agrupar as sub-bacias de 1ª ordem em funções de suas características geológicas, geomorfológicas e pedológicas (aspectos pedo-mórfico-litográficos). Especificamente para o planejamento territorial, mesmo sem trazer dados de uso e ocupação local, esses mapas possuem informações estratégicas para a compreensão e avaliação da dinâmica da paisagem naquela região.
Aktuelle Entwicklungen in Gesetzgebung und Rechtsprechung zum Familienrecht 2023
Authors: Fischer Martin
Published: December 2024

Dieser Beitrag informiert über die Entwicklungen im Familienrecht in der Rechtsprechung aus dem Jahr 2023. Er schließt an die Berichterstattungen der Vorjahre an (zuletzt Fischer, MDR 2023, 1431 ff.). Einen Schwerpunkt der diesjährigen Rechtsprechungsdarstellung bilden erneut die Entscheidungen zum Versorgungsausgleichsrecht.
Targeting CDK9 for treatment of colorectal cancer
Authors: Rahaman Muhammed H. , Lam Frankie , Zhong Longjin , Teo Theodosia , Adams Julian , Yu Mingfeng , Milne Robert W. , Pepper Chris , Lokman Noor A. , Ricciardelli Carmela , Oehler Martin K. , Wang Shudong
Published: August 2019

Colorectal cancer (CRC) remains one of the most lethal human malignancies, and pursuit of new therapeutic targets for treatment has been a major research focus. Cyclin‐dependent kinase 9 (CDK9), which plays a crucial role in transcription, has emerged as a target for cancer treatment. CDKI‐73, one of the most potent and pharmacologically superior CDK9 inhibitors, has demonstrated excellent anti‐tumour efficacy against several types of cancers. In this study, we evaluated its therapeutic potential against CRC. CDKI‐73 elicited high cytotoxicity against all colon cancer cell lines tested. Cell cycle and apoptosis analysis in HCT 116 and HT29 cells revealed that CDKI‐73 induced cell death without accumulation of DNA at any phase of the cell cycle. Moreover, it caused depolarisation of mitochondrial membrane, leading to caspase‐independent apoptosis. Knockdown by shRNA demonstrated the CDK9‐targeted mechanism of CDKI‐73, which also affected the Mnk/eIF4E signalling axis. In addition, RT‐qPCR analysis showed that CDKI‐73 down‐regulated multiple pro‐survival factors at the mRNA level. Its in vivo anti‐tumour efficacy was further evaluated in Balb/c nude mice bearing HCT 116 xenograft tumours. CDKI‐73 significantly inhibited tumour growth (***P < 0.001) without overt toxicity. Analysis of the tumour tissues collected from the xenografted animals confirmed that the in vivo anti‐tumour efficacy was associated with CDK9 targeting of CDKI‐73. Overall, this study provides compelling evidence that CDKI‐73 is a promising drug candidate for treating colorectal cancer.
Biomechanical Factors in Psoriatic Disease: Defective Repair Exertion as a Potential Cause. Hypothesis Presentation and Literature Review
Authors: Tönük Şükrü Burak , Yorgancıoğlu Zeynep Rezan
Published: August 2019

Joining main clinical manifestations of psoriatic skin disorder are inflammatory arthritis and nail lesions. Repetitive microdamage has been postulated as a main triggering factor in lesions of psoriatic arthritis. This concept of psoriatic disease might also be admissible for triggering nail lesions because the nail is a frequently traumatized structure. Here, we aimed to describe the conjectural injury mechanisms of nail complex with regard to acting biomechanical factors. Tissue repair response to physical microdamage may be altered in psoriatic disease. It is plausible to consider that a defective repair process in the dysregulated prepsoriatic tissue may lead to innate immune activation and further development of autoinflammatory lesions, although excessive inflammation is known to impair wound healing. Recently published data have revealed the importance of mechanosensitive Wingless‐type (Wnt) signaling in the pathophysiology of psoriasis and ankylosing spondylitis. The Wnt signaling system is involved in morphogenesis, repair, and regeneration as a biologic process main regulator. Wnt5a seems to be a dominating mediator in both psoriatic plaques and during the spondylitis process that might also be a linking molecule of psoriatic response to mechanical stress. Future studies should focus on complex responsive interactions of tissue repair regulators regarded in psoriatic disease.
State attorneys general join effort to make 42 CFR Part 2 like HIPAA
Authors: Knopf Alison
Published: August 2019

In a sign‐on letter released last week, 38 state attorneys general (AGs) called for weakening 42 CFR Part 2, the federal regulation that requires substance use disorder (SUD) treatment providers to obtain written consent from patients before releasing their information to anyone.
Interface Engineering for Both Cathode and Anode Enables Low‐Cost Highly Efficient Solution‐Processed CdTe Nanocrystal Solar Cells
Authors: Rong Zhitao , Guo Xiuzhen , Lian Shaoshan , Liu Songwei , Qin Donghuan , Mo Yueqi , Xu Wei , Wu Hongbin , Zhao Hong , Hou Lintao
Published: August 2019

Low‐cost solution‐processed CdTe nanocrystal (NC) solar cells always suffer from a high interface energy barrier and unbalanced hole/electron transport as well as anisotropic atom diffusion on the CdTe surface due to the limited amount of hole/electron interface materials or the difficulty in interface processing. In this work, a novel strategy is first adopted with gradient electron transport layer (CdS/CdSe) modification in the cathode and a new crosslinkable hole transport polymer (P‐TPA) implantation in the anode. The carrier recombination at interfaces is greatly decreased and thus the carrier collection is increased. Moreover, the light harvesting is improved both in short and long wavelength regions, making Jsc and Voc increase simultaneously. A champion solar cell shows a very high power conversion efficiency of 9.2% and an outstanding Jsc of 25.31 mA cm−2, which are among the highest values for all solution‐processed CdTe NC solar cells with a superstrate structure, and the latter value is even higher than that of traditional thick CdTe thin‐film solar cells (2 µm) via the high temperature close space sublimation method. This work demonstrates that facile surface modifications in both the cathode and anode with stepped extraction and organic–inorganic hybridization are very promising in constructing next‐generation highly efficient NC photovoltaic devices.
Bamboo‐Like Nitrogen‐Doped Carbon Nanotube Forests as Durable Metal‐Free Catalysts for Self‐Powered Flexible Li–CO2 Batteries
Authors: Li Xuelian , Zhou Jingwen , Zhang Junxiang , Li Matthew , Bi Xuanxuan , Liu Tongchao , He Tao , Cheng Jianli , Zhang Fan , Li Yongpeng , Mu Xiaowei , Lu Jun , Wang Bin
Published: August 2019

The Li–CO2 battery is a promising energy storage device for wearable electronics due to its long discharge plateau, high energy density, and environmental friendliness. However, its utilization is largely hindered by poor cyclability and mechanical rigidity due to the lack of a flexible and durable catalyst electrode. Herein, flexible fiber‐shaped Li–CO2 batteries with ultralong cycle‐life, high rate capability, and large specific capacity are fabricated, employing bamboo‐like N‐doped carbon nanotube fiber (B‐NCNT) as flexible, durable metal‐free catalysts for both CO2 reduction and evolution reactions. Benefiting from high N‐doping with abundant pyridinic groups, rich defects, and active sites of the periodic bamboo‐like nodes, the fabricated Li–CO2 battery shows outstanding electrochemical performance with high full‐discharge capacity of 23 328 mAh g−1, high rate capability with a low potential gap up to 1.96 V at a current density of 1000 mA g−1, stability over 360 cycles, and good flexibility. Meanwhile, the bifunctional B‐NCNT is used as the counter electrode for a fiber‐shaped dye‐sensitized solar cell to fabricate a self‐powered fiber‐shaped Li–CO2 battery with overall photochemical–electric energy conversion efficiency of up to 4.6%. Along with a stable voltage output, this design demonstrates great adaptability and application potentiality in wearable electronics with a breath monitor as an example.
Two‐Step Antisolvent Precipitated MAPbI3‐Pellet‐Based Robust Room‐Temperature Ammonia Sensor
Authors: Sheikh Arif D. , Vhanalakar Vishal , Katware Amarja , Pawar Krishna , Patil Pramod S.
Published: August 2019

Methylammonium lead tri‐iodide (MAPbI3) hybrid perovskite powder is successfully synthesized using a two‐step antisolvent precipitation (TSAP) method. This MAPbI3 powder is compressed to make a pellet, on the surface of which is designed an ammonia sensor that operates at room temperature. The tetragonal structure and porous morphology with well‐connected perovskite grains of the pellet are studied using X‐ray diffraction and scanning electron microscopy techniques. This is the first report of air‐stable, substrate free, and robust ammonia sensors based on perovskite pellets based in which the perovskite powder is synthesized with an unreported TSAP method. Gas‐sensing measurements show responsivity of 200% in 0.3 s and excellent recovery in 3.6 s upon exposure to 10 ppm ammonia gas. The sensor shows excellent structural and morphological ammonia sensing reversibility. A MAPbI3 pellet stored in ambient air with a relative humidity of 20–45% exhibits a lifetime of 60 d. These results successfully demonstrate new insights for environmentally friendly low‐cost manufacturing of highly sensitive robust perovskite ammonia sensors.
Revisiting the effect of time of birth on neonatal, infant, and child mortality in rural Spain, 1830‐1929
Authors: Marco‐Gracia Francisco J.
Published: August 2019

Objectives

This article aims to determine whether different patterns of mortality occurred among children born during the day and the night respectively, between 1830 and 1929.

Methods

The data include the time of birth and death of 9814 individuals from 10 villages in rural Spain between 1830 and 1929, within a context of natural births at home with little medical support. These data were subjected to a comparative analysis relating to the time of birth and the age at death.

Results

Neonatal, infant, and child mortality was higher for children born during daytime. The day‐to‐night mortality pattern diverged until children were at least 5 years old.

Conclusions

The results confirm that the mortality patterns differed according to the time of birth. Possibly some of these children experienced longer or problematic deliveries that, in the absence of good medical assistance, had health consequences during the following days and years of life.
Historical recollection of anthropometric data from schoolchildren attending summer camps from 1887 to 1934 in Spain: Interpretations and comparison with coetaneous and modern references
Authors: Herráez Angel , López‐Ejeda Noemí , Marrodán María Dolores , González‐Montero de Espinosa Marisa
Published: August 2019

Objectives

Around the aim of gaining knowledge on the secular trends in nutritional status of the Spanish population, we found a collection of historical records compiled by La Institución Libre de Enseñanza and their alumni association along 47 years. These data had been collected from boys and girls attending summer camps, with a policy of improving health of children with unfavorable socioeconomic conditions. The objective is to extract all possible information about growth changes, and eventually any interpretation related to status of the originating families.

Materials and methods

Primary data were collected from both unpublished manuscripts containing the original records and publications of the organizing institutions. They had been gathered from 86 summer camps in Spain from 1887 to 1934. In these camps, detailed anthropometric data were collected from every attendee, including body height and weight. The sample population amounts to 1,791 boys and 1,281 girls, between 7 and 16 years of age.

Results

Body height and weight, pooled by camp year, age and sex, displayed variable secular increases. A similar observation appears for the body mass index (BMI). As a complement, a comparison was done to contemporary published references from both Spanish and international studies.

Discussion

Height, weight, and BMI from the camps may be judged as retardation of growth and malnutrition by modern standards but it is not the case when coetaneous references are considered: no overall significant differences were found with respect to several publications from Spanish and European populations.
Structurally Precise Silver Sulfide Nanoclusters Protected by Rhodium(III) Octahedra with Aminothiolates
Authors: Ueda Misaki , Goo Zi Lang , Minami Katsue , Yoshinari Nobuto , Konno Takumi
Published: August 2019

A 60‐nuclear silver sulfide nanocluster with a highly positive charge (1) has been synthesized by mixing an octahedral RhIII complex with 2‐aminoethanethiolate ligands, silver(I) nitrate, and d‐penicillamine in water under mild conditions. The spherical surface of 1 is protected by the chiral octahedral RhIII complex, with cleavage of the C−S bond of the d‐penicillamine supplying the sulfide ions. Although 1 does not contain d‐penicillamine, it is optically active because of the enantiomeric excess of the RhIII molecules induced by chiral transfer from d‐penicillamine. 1 can accommodate/release external Ag+ ions and replace inner Ag+ ions by Cu+ ions. The study demonstrates that a thiolato metal complex and sulfur‐containing amino acid can be used as cluster‐surface‐protecting and sulfide‐supplying regents, respectively, for creating chiral, water‐soluble, structurally precise silver sulfide nanoclusters, the properties of which are tunable through the addition/removal/exchange of Ag+ ions.
Bridging the Gap between Structurally Distinct 2D Lamellar Zeolitic Precursors through a 3D Germanosilicate Intermediate
Authors: Xu Le , Choudhary Madhuresh K. , Muraoka Koki , Chaikittisilp Watcharop , Wakihara Toru , Rimer Jeffrey D. , Okubo Tatsuya
Published: August 2019

There is broad scientific interest in lamellar zeolitic materials for a large variety of technological applications. The traditional synthetic methods towards two‐dimensional (2D) zeolitic precursors have made a great impact in the construction of families of related zeolites; however, the connection between structurally distinct 2D zeolitic precursors is much less investigated in comparison, thereby resulting in a synthetic obstacle that theoretically limits the types of zeolites that can be constructed from each layer. Herein, we report a Ge‐recycling strategy for the topotactic conversion between different 2D zeolitic precursors through a three‐dimensional (3D) germanosilicate. Specifically, the intermediate germanosilicate can be constructed within 150 min by taking advantage of its structural similarity with the parent lamellar precursor. This process enables the conversion of one 2D zeolite structure into another distinct structure, thus overcoming the synthetic obstacle between two families of zeolitic materials.
A Dual Killing Strategy: Photocatalytic Generation of Singlet Oxygen with Concomitant PtIV Prodrug Activation
Authors: Norman Daniel J. , Gambardella Alessia , Mount Andrew R. , Murray Alan F. , Bradley Mark
Published: August 2019

A ruthenium‐based mitochondrial‐targeting photosensitiser that undergoes efficient cell uptake, enables the rapid catalytic conversion of PtIV prodrugs into their active PtII counterparts, and drives the generation of singlet oxygen was designed. This dual mode of action drives two orthogonal cancer‐cell killing mechanisms with temporal and spatial control. The designed photosensitiser was shown to elicit cell death of a panel of cancer cell lines including those showing oxaliplatin‐resistance.
Synthesis of A Pincer‐IrVComplex with A Base‐Free Alumanyl Ligand and Its Application toward the Dehydrogenation of Alkanes
Authors: Morisako Shogo , Watanabe Seiya , Ikemoto Satoru , Muratsugu Satoshi , Tada Mizuki , Yamashita Makoto
Published: August 2019

A pincer‐iridium complex bearing a Lewis‐base‐free X‐type alumanyl ligand has been synthesized. X‐ray diffraction, NMR and IR spectroscopy, as well as XANES analysis confirmed its tetrahydrido‐IrVstructure and Lewis acidity at the Al center as supported by DFT calculations. The resulting complex was applied as a catalyst for the transfer dehydrogenation of cyclooctane.
Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer–Lipid Amphiphile Conjugates of Small‐Molecule TLR7/8 Agonists
Authors: De Vrieze Jana , Louage Benoit , Deswarte Kim , Zhong Zifu , De Coen Ruben , Van Herck Simon , Nuhn Lutz , Kaas Frich Camilla , Zelikin Alexander N. , Lienenklaus Stefan , Sanders Niek N. , Lambrecht Bart N. , David Sunil A. , De Geest Bruno G.
Published: August 2019

Uncontrolled systemic inflammatory immune triggering has hampered the clinical translation of several classes of small‐molecule immunomodulators, such as imidazoquinoline TLR7/8 agonists for vaccine design and cancer immunotherapy. By taking advantage of the inherent serum‐protein‐binding property of lipid motifs and their tendency to accumulate in lymphoid tissue, we designed amphiphilic lipid–polymer conjugates that suppress systemic inflammation but provoke potent lymph‐node immune activation. This work provides a rational basis for the design of lipid–polymer amphiphiles for optimized lymphoid targeting.
Synthesis, spectroscopic characterization, biological screening and in vitro cytotoxic studies of 4‐methyl‐3‐thiosemicarbazone derived Schiff bases and their Co (II), Ni (II), Cu (II) and Zn (II) complexes
Authors: Devi J. , Yadav M. , Jindal D.K. , Kumar D. , Poornachandra Y.
Published: August 2019

A series of twenty compounds inclusive of bidentate Schiff bases derived from condensation of 4‐methyl‐3‐thiosemicarbazide with substituted derivatives of napthaldehyde/benzaldehyde/salicylaldehyde and their mononuclear Co (II), Ni (II), Cu (II) and Zn (II) complexes in molar ratio (1:1) were synthesized and characterized. The coordination behavior, modes of bonding and overall geometry of the compounds was known from the elemental analysis, spectral techniques (IR, UV–Vis, 1H NMR, 13C NMR, ESR and ESI‐mass), magnetic moment measurements, molar conductance, thermal and powder XRD studies. The studies revealed octahedral geometry for all the complexes where ligands coordinated in a neutral bidentate manner (NS) via nitrogen atom of azomethine group and sulphur atom of thione group with the metal centre. In vitro biological effects of the compounds were tested against four bacterial species and two fungal strains. The results indicated that the metal complexes showed a marked enhancement in biocidal activity in comparable with the parent Schiff bases. In vitro anticancer activity against the malignant tumor cell lines; human alveolar adenocarcinoma epithelial cell line (A549), human breast adenocarcinoma cell line (MCF7), human prostate cancer cell line (DU145) and human normal lung cell line (MRC‐5) using MTT assay, exposed compound 16 as a leading member with lowest IC50 value of 10.6 ± 0.14 μM against (A549) cell line.
Integrated pest management in the academic small greenhouse setting: A case study using Solanum spp. (Solanaceae)
Authors: Hayes Daniel S. , Jordon‐Thaden Ingrid E. , Cantley Jason T. , McDonnell Angela J. , Martine Christopher T.
Published: August 2019

Premise

Botanical faculty and staff at academic institutions are often tasked with establishing and/or caring for plant collections held in small greenhouse facilities. Once plants are in place, an especially acute challenge is managing plant pest/pathogen populations. Integrated pest management (IPM) approaches are an excellent option, but few examples exist in the literature of successful programs that have been developed in academic small greenhouse settings.

Methods and Results

Over several years, we developed an IPM program for two small research greenhouses on the campus of a primarily undergraduate institution where hundreds of plants have been grown for studies in the genus Solanum. We here present a synopsis of the cultural, mechanical, physical, and biological controls used as part of our successful IPM strategy—including details on the efficacy of multiple predatory insects—with the hope of providing a model for sustainable pest management in the higher education environment.

Conclusions

IPM can be an effective strategy for maintaining healthy plant populations in small research greenhouses, but it requires a consistent investment of time and funding. A well‐cared‐for plant collection might help support numerous positive outcomes, including advances in faculty scholarship and opportunities for student learning and/or training.
Click chemistry based regioselective one‐pot synthesis of coumarin‐3‐yl‐methyl‐1,2,3‐triazolyl‐1,2,4‐triazol‐3(4H)‐ones as newer potent antitubercular agents
Authors: Somagond Shilpa M. , Kamble Ravindra R. , Bayannavar Praveen K. , Shaikh Saba Kauser J. , Joshi Shrinivas D. , Kumbar Vijay M. , Nesaragi Aravind R. , Kariduraganavar Mahadevappa Y.
Published: August 2019

Coumarin‐3‐yl‐methyl‐1,2,3‐triazolyl‐1,2,4‐triazol‐3(4H)‐ones (8k‐z) were synthesized via copper(I)‐catalyzed azide‐alkyne cycloaddition click chemistry. The synthesized hybrid molecules were characterized by spectral studies. Compounds 8k‐z were screened for their in vitro anti‐TB activity by using the Microplate Alamar Blue assay and for cytotoxicity using the MTT assay. Some of the compounds were found to be most potent against the tested Mycobacterium tuberculosis H37Rv strain with a MIC of 1.60 µg/ml. Further, docking the compounds into the InhA binding pocket showed strong binding interactions and effective overall docking scores were recorded. The drug‐likeness and toxicity studies were computed using Molinspiration and Protox, respectively.
Quantile forecasting based on a bivariate hysteretic autoregressive model with GARCH errors and time ‐varying correlations
Authors: Chen Cathy W.S. , Than‐Thi Hong , So Mike K.P. , Sriboonchitta Songsak
Published: August 2019

To understand and predict chronological dependence in the second‐order moments of asset returns, this paper considers a multivariate hysteretic autoregressive (HAR) model with generalized autoregressive conditional heteroskedasticity (GARCH) specification and time‐varying correlations, by providing a new method to describe a nonlinear dynamic structure of the target time series. The hysteresis variable governs the nonlinear dynamics of the proposed model in which the regime switch can be delayed if the hysteresis variable lies in a hysteresis zone. The proposed setup combines three useful model components for modeling economic and financial data: (1) the multivariate HAR model, (2) the multivariate hysteretic volatility models, and (3) a dynamic conditional correlation structure. This research further incorporates an adapted multivariate Studenttinnovation based on a scale mixture normal presentation in the HAR model to tolerate for dependence and different shaped innovation components. This study carries out bivariate volatilities, Value at Risk, and marginal expected shortfall based on a Bayesian sampling scheme through adaptive Markov chain Monte Carlo (MCMC) methods, thus allowing to statistically estimate all unknown model parameters and forecasts simultaneously. Lastly, the proposed methods herein employ both simulated and real examples that help to jointly measure for industry downside tail risk.
Process research in early intensive intervention in autism spectrum disorder: Sensitivity to change of the autism behavior coding system
Authors: Herbrecht Evelyn , Lazari Olga , Notter Marianne , Schmeck Klaus , Spiegel René
Published: August 2019

The development of sensitive measures to capture changes in core autism symptoms is crucial in early intervention research. The study examines the sensitivity to change of the Autism Behavior Coding System (ABCS), a video‐based instrument to assess core autism symptoms during therapist‐child interaction. Video sequences of 40 young children treated in the Frühintervention bei Autistischen Störungen center were analyzed with regard to the question of whether short‐term changes during an 18 day period of early intervention could be captured, and whether these results are reflected in an independent clinical assessment (Developmental Disorders‐Child‐Global Assessment Scale [DD‐C‐GAS]). ABCS results showed statistically significant improvements on behavioral domains such as “expression of wishes” and “social cooperative behavior” (P < 0.01), less pronounced on “eye contact.” Improvements on the DD‐C‐GAS were highly significant on all subdomains. Both scales showed high correlations within their subdomains, yet no significant correlations between the changes in both instruments' scores were found. An additional analysis between the DD‐C‐GAS scores at day 18 and the changes in the ABCS scores showed statistically significant associations in the expected direction between the changes in the variable “eye contact” and all DD‐C‐GAS subdomains. The correspondence of the two levels of assessment is low, but the specifics of this relationship deserve further study. The ABCS may prove useful in addition to standard assessment tools, especially in early intervention research settings, as it allows reliable analysis of core behavioral elements in young children with autism. Autism Res 2019, 12: 1817–1828. © 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc.

Lay Summary

The study examined the sensitivity of an autism‐specific video coding system (ABCS) in assessing changes after an 18 day period of intensive early intervention. Video sequences of therapist‐child‐interaction of 40 young children with autism spectrum disorder (ASD) were analyzed. Children's behavior improved in expression of wishes, social cooperativity and eye contact. A therapist‐based global assessment scale also showed important improvement after 18 days, yet both assessment instruments showed weak correlations between their respective changes. We showed that the ABCS may prove useful in capturing short‐term changes in autism‐related behaviors, especially in early intervention research.
Hyperthermophilic flavin reductase from Sulfolobus solfataricus P2: Production and biochemical characterization
Authors: Gun Gokhan , Imamoglu Rahmi , Tatli Ozge , Yurum Yuda , Tarik Baykal Ahmet , Dinler‐Doganay Gizem
Published: August 2019

Nicotinamide adenine dinucleotide phosphate (NAD(P)H)‐flavin oxidoreductases (flavin reductases) catalyze the reduction of flavin by NAD(P)H and provide the reduced form of flavin mononucleotide (FMN) to flavin‐dependent monooxygenases. Based on bioinformatics analysis, we identified a putative flavin reductase gene, sso2055, in the genome of hyperthermophilic archaeon Sulfolobus solfataricus P2, and further cloned this target sequence into an expression vector. The cloned flavin reductase (EC. 1.5.1.30) was purified to homogeneity and characterized further. The purified enzyme exists as a monomer of 17.8 kDa, free of chromogenic cofactors. Homology modeling revealed this enzyme as a TIM barrel, which is also supported by circular dichroism measurements revealing a beta‐sheet rich content. The optimal pH for SSO2055 activity was pH 6.5 in phosphate buffer and the highest activity observed was at 120 °C within the measurable temperature. We showed that this enzyme can use FMN and flavin adenine dinucleotide (FAD) as a substrate to generate their reduced forms. The purified enzyme is predicted to be a potential flavin reductase of flavin‐dependent monooxygenases that could be involved in the biodesulfurization process of S. solfataricus P2.
3D‐Architektur des Chromatins reguliert Extremitäten‐Entwicklung
Authors: Kronberg Inge
Published: August 2019

Zwei Beine zum Laufen, zwei Arme zum Hantieren – „Vierbeiner“ im wörtlichen Sinne sind Menschen eigentlich nicht. Unter den Tetrapoden (Landwirbeltieren) bilden sie da keine Ausnahme: Aus ursprünglich vier gleichen Extremitäten‐Anlagen entwickeln sich spiegelsymmetrische Paare von unterschiedlich spezialisierten Vorder‐ und Hinterextremitäten. Für die Entwicklung zu Hinterbeinen sorgt das Gen Pitx1, sobald es vom Enhancer Pen aktiviert wird. In den Zellen der Vorderbeinanlage gibt es aufgrund einer anderen dreidimensionalen Chromatinstruktur keinen Kontakt zwischen Pitx1 und Pen, so dass die Entwicklung der Vorderbeine einen anderen Verlauf nimmt.
Das Pferd: vom lebenden Proviant zum unverzichtbaren Arbeitstier und Wirtschaftsfaktor
Authors: Winter Dirk
Published: August 2019

„Das Glück der Erde liegt auf dem Rücken der Pferde“– Pferd und der Mensch haben seit Jahrtausenden eine innige Beziehung, und ohne das Pferd wäre die menschliche Entwicklung vermutlich anders verlaufen. Zuerst war es Nahrungsmittellieferant, später dann unverzichtbares Arbeits‐ und Kriegstier, und heute steht es in der westlichen Welt eher für Sport‐ und Freizeitgestaltung. Aber auch die emotionale Nähe zum Pferd spielt eine wesentliche Rolle insbesondere für Mädchen und junge Frauen. Das Tier zu pflegen und Verantwortung zu tragen ist ein wichtiger Schritt zum Erwachsenwerden. So unterstützen Pferde dabei, selbstständig zu werden.
Knockdown of SP1/Syncytin1 axis inhibits the proliferation and metastasis through the AKT and ERK1/2 signaling pathways in non‐small cell lung cancer
Authors: Li Xiaohui , Fu Yang , Xia Xiyan , Zhang Xin , Xiao Ke , Zhuang Xuewei , Zhang Yi
Published: August 2019

Syncytin 1 is considered as an oncogene in various malignant tumors, but its effect on non‐small cell lung cancer (NSCLC) has not been reported. We investigated the specific role of Syncytin 1 on NSCLC through the transfection of Syncytin 1 knockdown or overexpression plamids in A549 cells. Our results proved that knockdown of Syncytin 1 inhibited the proliferation, and blocked the cell cycle on G1 phase by inhibiting the expression of Nusap1, Cyclin D1, CDK6, and CDK4. Cell cycle arrest also leaded to increased apoptosis in Syncytin 1 knockdown cells. Suppression of Syncytin 1 inhibited the migration and invasion, as well as the expressions of epithelial‐mesenchymal transition (EMT) makers, N‐cadherin, β‐catenin, and Vimentin, indicating that Syncytin 1 knockdown inhibited the metastasis via reversing the EMT process in A549 cells. The phosphorylation levels of Akt, mTOR, and Erk1/2 were all decreased in Syncytin 1 knockdown cells, suggesting the signaling pathways by which Syncytin 1 operated as an oncogene in NSCLC. Moreover, the underexpression of transcription factor SP1 downregulated the Syncytin 1 expression in A549 cells. The rescue experiment of Syncytin 1 in SP1 knockdown cells further proved that Syncytin 1 could block the inhibition of cell growth induced by SP1 knockdown. In conclusion, knockdown of SP1/Syncytin1 axis inhibited the progression of NSCLC by the reversion of tumor epithelial‐mesenchymal transition process and suppression of Akt and Erk signaling pathways, suggesting that they are potential targets for targeted therapy of NSCLC.
Prognostic role of diastolic dysfunction in patients undergoing transcatheter aortic valve replacement
Authors: Kampaktsis Polydoros N. , Vavuranakis Manolis , Choi Daniel Y. , Sherifi Ines , Christofi Angela , Triantafyllou Dionysis , Siasos Gerasimos , Salemi Arash , Tousoulis Dimitrios , Wong S. Chiu , Devereux Richard B.
Published: August 2019

Objectives

Prior studies have shown that left ventricular diastolic dysfunction (DD) is associated with increased mortality after surgical aortic valve replacement but studies on transcatheter aortic valve replacement (TAVR) are limited and have not taken into account mitral annular calcification (MAC), which limits the use of mitral valve annular tissue Doppler imaging. We performed a single‐center retrospective analysis to better evaluate the role of baseline DD on outcomes after TAVR.

Methods

After excluding patients with atrial fibrillation, mitral valve prostheses and significant mitral stenosis, 359 consecutive TAVR patients were included in the study. Moderate‐to‐severe MAC was present in 58% of the patients. We classified patients into severe versus nonsevere DD based on the evaluation of elevated left ventricular filling pressure. The outcome measure was all‐cause mortality or heart failure hospitalization.

Results

Over a mean follow‐up time of 13 months, severe DD was associated with an increased risk for the outcome measure (HR 2.02 [1.23–3.30], p = .005). However, this association was lost in a propensity‐matched cohort. In multivariate analysis, STS score was the only independent predictor of all cause mortality of heart failure hospitalization (HR 1.1 [1.05–1.15], p < .001).

Conclusions

We evaluated the role of baseline DD on outcomes after TAVR by taking into account the presence of MAC. Severe DD was associated with increased all‐cause mortality or heart failure hospitalization but not independently of other structural parameters and known predictors of the outcome measure.
Anemia and leukopenia following intravenous colloidal silver infusions—Clinical and hematological features, unique peripheral blood film appearance and effective therapy with supplemental oral copper and apheresis
Authors: Natelson Ethan A. , Baker Kelty R. , Pyatt David W.
Published: August 2019

Alternative medical therapy with multiple intravenous colloidal silver infusions may cause severe illness, including profound copper deficiency‐induced anemia and hepatic toxicity. No chelating agent for silver poisoning exists and effective therapy requires apheresis in combination with continuous administration of oral copper.
Role of Iron on the Structure and Stability of Ni3.2Fe/Al2O3 during Dynamic CO2 Methanation for P2X Applications
Authors: Serrer Marc‐André , Kalz Kai F. , Saraҫi Erisa , Lichtenberg Henning , Grunwaldt Jan‐Dierk
Published: August 2019

An energy scenario, mainly based on renewables, requires efficient and flexible Power‐to‐X (P2X) storage technologies, including the methanation of CO2. As active Ni0 surface sites of monometallic nickel‐based catalysts are prone to surface oxidation under hydrogen‐deficient conditions, we investigated iron as “protective” dopant. A combined operando X‐ray absorption spectroscopy and X‐ray diffraction setup with quantitative on‐line product analysis was used to unravel the structure of Ni and Fe in an alloyed Ni−Fe/Al2O3 catalyst during dynamically driven methanation of CO2. We observed that Fe protects Ni from oxidation and is itself more dynamic in the oxidation and reduction process. Hence, such “sacrificial” or “protective” dopants added in order to preserve the catalytic activity under dynamic reaction conditions may not only be of high relevance with respect to fine‐tuning of catalysts for future industrial P2X applications but certainly also of general interest.