bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis of New Chiral N-alkyl Betti-base Ligands via One-Pot Three Component Strategy
Authors: Ganesh Siva , Sarika Kondabatini , Reddy Pedavenkatagari Narayana , Padmaja Pannala
Published: January 2021

Background:

Betti base derivatives were employed as chiral ligands or as chiral auxiliaries
in asymmetric transformations. In particular, N-alkyl Betti base derivatives are gaining importance
as excellent ligands in asymmetric reactions. However, no appropriate method exists for
regioselective N-alkylation of Betti base. Therefore, there is an urgent need to develop a new protocol
for the regioselective N-alkylation of chiral Betti-base.

Methods:

An efficient method has been developed for one-pot synthesis of chiral N-alkyl Bettibase
ligands from (S)-(+)-Betti base, arylglyoxals and cyclic 1,3-C,N-binucleophiles under catalyst-
free conditions.

Results:

The chiral N-alkyl Betti-base ligands were obtained in good yields with excellent enantioselectivities.
This method is rapid, clean and does not require a catalyst or chromatographic purification.

Conclusion:

We have developed an efficient one-pot three component strategy for the synthesis of
new chiral N-alkyl Betti-base ligands from (S)-(+)-Betti base, arylglyoxals and cyclic 1,3-C,Nbinucleophiles
in the absence of a catalyst.
Low Doses Naltrexone: The Potential Benefit Effects for its Use in Patients with Cancer
Authors: Couto Ricardo David , Fernandes Bruno Jose Dumêt
Published: January 2021

Naltrexone (NTX) is an opioid antagonist that inhibits cell proliferation in vivo when administered
in low doses. Naltrexone in low doses can reduce tumor growth by interfering with cell
signalling as well as by modifying the immune system. It acts as an Opioid Growth Factor receptor
(OGFr) antagonist and the OGF-OGFr axis is an inhibitory biological pathway present in human
cancer cells and tissues, being a target for the treatment with naltrexone low-dose (LDN). Clinical
trials have proposed a unique mechanism(s) allowing LDN to affect tumors. LDN shows promising
results for people with primary cancer of the bladder, breast, liver, lung, lymph nodes, colon and
rectum. This short review provides further evidence to support the role of LDN as an anticancer
agent.
Isolated photovoltaic system for house: pre-sizing
Authors: Veliz Jessica Katherine Moreira , Gualán Juan Francisco Velepucha , Mateo Felipe Alejandro León , Veléz Andy Ariel Guerrero , Gámez María Rodríguez
Published: January 2021

Photovoltaic solar energy is a clean renewable energy source that allows obtaining electricity directly from solar radiation through semiconductor devices called photovoltaic cells. The present research aims to pre-design an isolated system for a house that can serve as a pattern for the electrification of houses that today do not have power in the province of Manabí. To carry out the proposal, the PVsyst was used, a tool for sizing the system, in addition to the bibliographic review, the qualitative-quantitative, and the inductive deductive. It was obtained as a result that photovoltaic solar energy is adequate to provide a solution to isolated homes that today do not have energy service, in addition to those that have a poor quality of service.
Hacia la configuración de un sistema de seguridad colectiva
Authors: Arenas Piedrahita Angie Julieth , Mejía Prieto Juan Camilo , Rayran Cortés Manuel Alejandro
Published: January 2021

El presente capítulo aborda cronológicamente la evolución de la seguridad colectiva, cuyas raíces parten de una concepción imperial que dominó las dinámicas de la guerra en Europa y que, finalmente, desencadenarían la Primera Guerra Mundial. El siglo xx fue marcado por sesgos ideológicos que crearon la bipolaridad propia del periodo y que profundizaron todavía más el realismo político imperante en el sistema internacional. La destrucción dejada por la Segunda Guerra Mundial sería el catalizador que facilitaría la creación de una organización supranacional que finalmente se encargase de garantizar la paz y la seguridad internacionales. Finalmente, la modernidad trae inmensos retos en materia de seguridad derivados de una nueva forma de conflictividad en la que los actores estatales no se enfrentan entre sí, sino que se enfrentan (o patrocinan) a organizaciones que representan identidades políticas, religiosas, o raciales frente a las cuales la Organización de las Naciones Unidas desafortunadamente no tiene injerencia alguna.
La guerra civil siria y el papel de las Naciones Unidas
Authors: Rayran Cortés Manuel Alejandro
Published: January 2021

Desde 2011, la República Árabe de Siria ha estado inmersa en un conflicto armado cuyas características particulares han obligado a evaluar las acciones de las instituciones internacionales para garantizar la paz internacional. Con el fin de comprender de manera clara los orígenes de los enfrentamientos bélicos, en este capítulo se explican los hitos, quiénes fueron los actores principales y sus intereses; además, se determina la naturaleza de la guerra. De igual manera, se analiza el papel del Consejo de Seguridad de Naciones Unidas, sus dificultades para resolver el conflicto y el protagonismo de las organizaciones regionales, así como de otras instituciones subsidiarias de las Naciones Unidas, para reducir la guerra. Por último, se evidencian las fallas estructurales de la seguridad colectiva, se muestra cómo los intereses geopolíticos en el seno de las instituciones causan daños irreparables a la población civil y se exponen las razones por las cuales este tipo de guerras son el resultado de un debilitamiento del Estado.
Amenaza terrorista de Boko Haram, el rol de las Naciones Unidas en el conflicto armado en Nigeria
Authors: Arenas Piedrahita Angie Julieth
Published: January 2021

El presente capítulo analiza el rol de la onu en la resolución del conflicto armado nigeriano, a partir del estudio del nacimiento y evolución de la organización terrorista Boko Haram y su impacto en la región. Para ello, se empleó una metodología de estudio de caso, con enfoque cualitativo y alcance explicativo. Dentro de los principales hallazgos de la investigación cabe destacar el papel limitado de la Organización en las etapas iniciales del conflicto, la internacionalización de este como parte del juego de poder entre las poten-cias del sistema internacional, y la preponderancia de los actores no estatales en la visibilización del drama humano ocasionado por las acciones del Estado Islámico en África Occidental. De allí, que se plantee la necesidad de reestructurar el Sistema de Naciones Unidas desde su misionalidad y alcance real, y replantear la lucha contra el terrorismo internacional desde un enfoque de derechos humanos.
Comparing Phonetic Complexity between Fluent and Disfluent Eojeols in Adults Who Stutter
Authors: Chon HeeCheong
Published: January 2021

Purpose: The purpose of this study was to investigate the characteristics of phonetic complexity in disfluent eojeols of adults who stutter. Therefore, phonetic complexity between fluent and disfluent [including stuttering-like disfluency (SLD) or other disfluency (OD)] eojeols was compared using two speaking tasks.Methods: Twenty-one adults who stutter performed a picture description task and a conversation task. Those speech samples were divided into eojeols, and each eojeol was classified as a “fluent eojeol” if it was perceptually fluent, an “OD eojeol” if it was produced with ODs, or an “SLD eojeol” if it was produced with SLDs. The index of phonetic complexity (IPC) and the phonological mean length of utterance (PMLU) were measured to compare phonetic complexity between the tasks and the types of eojeols.Results: The IPC was significantly the greatest in the SLD eojeol regardless of task. The IPC of the fluent eojeol was significantly greater than that of the OD eojeol. The SLD eojeol also showed significantly the greatest PMLU among the types of eojeols, and the fluent eojeol showed significantly greater PMLU than the OD eojeol. Significant positive correlations were found between IPCs and PMLUs for each eojeol no matter the task.Conclusion: When producing eojeols, greater phonetic complexity can trigger SLDs in adults who stutter, supporting the psycholinguistic aspects of stuttering.
Implementation of high-order, discontinuous Galerkin time stepping for fractional diffusion problems
Authors: McLean William
Published: January 2021

The discontinuous Galerkin (DG) method provides a robust and flexible technique for the time integration of fractional diffusion problems. However, a practical implementation uses coefficients defined by integrals that are not easily evaluated. We describe specialized quadrature techniques that efficiently maintain the overall accuracy of the DG method. In addition, we observe in numerical experiments that known superconvergence properties of DG time stepping for classical diffusion problems carry over in a modified form to the fractional-order setting.
doi: 10.1017/S1446181120000152
Yoga: A Potential Adjunct Therapy to Current Rehabilitation Pathways in Cardiac Conditions and Stroke
Authors:   Stroke and Ageing Research, Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia, Thayabaranathan Tharshanah , Cameron Jan , Murphy Barbara , Cadilhac Dominique A
Published: January 2021

Yoga is a form of movement-based mindfulness practice that enhances the mind-body connection to benefit overall health and well-being. Although the practices of yoga are ancient traditions in the Buddhist and Hindu philosophies, scientific research regarding the impacts of yoga among people with poor cardiovascular and cerebrovascular health has only recently been undertaken. In this article, we highlight the current evidence on the potential impact of yoga on physical and psychological well-being for older adults living with cardiac conditions or stroke.
PLATELET RICH PLASMA (PRP) DARI LIMBAH DARAH SAPI SEBAGAI OBAT LUKA BAKAR PADA TIKUS PUTIH (Rattus norvegicus)
Authors: Ardhiansyah Rahmad Dwi , Baihaqie Riefky Pradipta , Naufal Muhammad Nuriy Nuha , Farma Nanda Muhamad Atabika , Maharani Aprilia , Fibrianto Yuda Heru
Published: January 2021

Luka bakar adalah kerusakan jaringan pada kulit akibat terpajan panas tinggi, bahan kimiawi maupun arus listrik. Salah satu hewan yang disembelih di Rumah Potong Hewan (RPH)  adalah sapi. Seekor sapi dapat menghasilkan  limbah  darah kurang lebih sebanyak 28 liter. Komponen darah terdiri dari plasma, sel darah merah, sel darah putih dan platelet. Platelet mengandung growth factor. Platelet Rich Plasma (PRP) atau plasma yang kaya akan platelet terbukti dapat mempercepat penyembuhan tulang dan jaringan lunak. Pembuatan PRP dari darah sapi dilakukan dengan metode sentrifuge. Hewan coba  yang dipakai pada penelitian ini adalah tikus putih sebanyak 10 ekor. Besi panas berbentuk bulat dipanaskan dengan api, lalu ditempelkan pada kulit. Kelompok perlakuan diberi PRP dengan konsentrasi 10%, 20% dan 30% dengan salep vaselin album, kelompok kontrol negatif yang tidak diberi perlakuan dan kelompok kontrol positif yang diberi obat yang terbuat dari ekstrak plasenta sapi 10%+neomycin sulfate 0,5%. Parameter yang dipakai untuk mengukur tingkat kesembuhan luka adalah waktu kesembuhan dan pemeriksaan histopatologi. Pada hasil pengukuran waktu kesembuhan dianalisis dengan metode statistik One-way Analsisis of variance (Anova) tingkat signifikansi 95% dengan Kruskal-wallis, kesembuhan luka terdapat perbedaan signifikan antara PRP konsentrasi 10%, 20%, 30%, dan kontrol positif dengan kontrol negatif. Konsentrasi PRP yang optimal adalah 20%. Analisa tipe jaringan yang terbentuk dilakukan dengan pembuatan preparat histopatologi, hasil menunjukkan bahwa luka pada kelompok perlakuan dan kontrol positif  tampak sembuh, sedangkan kelompok kontrol negatif epitelisasi belum tertutup jelas. PRP merupakan obat penyembuh luka bakar yang efektif sebagai pengganti obat komersil yang sudah tersedia.
Pemberian Ekstrak Etanol Daun Jambu Mete (Anacardium occidentale) terhadap Produksi IL-6 dan SOD pada Mencit Fibrosis Hati yang Diinduksi CCl4
Authors: Hutabarat Mariana Ruth Theresia
Published: January 2021

Fibrosis hati merupakan akumulasi berlebih matriks ekstraseluler. Prevalensi fibrosis hati hewan kecil dilaporkan mencapai 10% dari keseluruhan penyakit sistemik hewan kecil di Amerika Serikat. Salah satu bahan toksik yang menimbulkan fibrosis hati adalah carbon tetrachloride (CCl4). Penelitian ini bertujuan untuk mengetahui pengaruh preventif ekstrak etanol daun jambu mete (Anacardium occidentale) terhadap produksi Interleukin-6 (IL-6) dan kadar superoxide dismutase (SOD). Daun jambu mete mengandung bahan aktif flavonoid yang memiliki efek antiinflamasi dan antioksidan. Penelitian ini merupakan studi eksperimental, post-test control only design dengan menggunakan Rancangan Acak Lengkap. Hewan coba mencit (Mus musculus) dibagi dalam 5 kelompok perlakuan, yaitu kelompok kontrol negatif, kontrol positif, kelompok preventif dengan dosis 500 mg/kg BB, 1000 mg/kg BB, dan 1500 mg/kg BB. Produksi sitokin IL-6 dihitung menggunakan metode flowcytometry, sedangkan kadar SOD diukur menggunakan spektofotometri. Data hasil uji dianalisa secara statistik ­one way ANOVA (α=0,05) dengan uji lanjutan Post Hoc Tukey. Simpulan dari penelitian ini yaitu preventif menggunakan ekstrak etanol daun jambu mete mencegah peningkatan produksi IL-6 dan meningkatkan kadar SOD pada mencit model fibrosis hati. Persentase produksi IL-6 pada kelompok perlakuan dosis 1500 mg/kg BB sebesar 2,58%. Kadar SOD pada kelompok perlakuan dosis 1500 mg/kg BB sebesar 4,23%.
Electrical stunning sebelum penyembelihan dapat menurunkan Serum Superoxide Dismutase Babi Landrace Crossbred
Authors: Prayoga Shabrina Fauzia , Fikri Faisal , Purnama Muhammad Thohawi Elziyad
Published: January 2021

Penelitian bertujuan untuk mengevaluasi enzim Superoxide Dismutase (SOD) pada serum babi Landrace Crossbred yang mendapat electrical stunning dan tanpa electrical stunning sebelum penyembelihan. Sebanyak 18 ekor babi Landrace Crossbred jantan dewasa kebiri dan bobot 115±20 kg dibagi menjadi dua perlakuan, yakni electrical stunning dan tanpa electrical stunning dengan pengujian serum pada pre dan post perlakuan. Sebanyak 3 ml sampel darah diambil dan diuji kadar SOD dengan StressXpress® kit. Pembacaan kadar SOD diuji normalitas dengan Shapiro-Wilk Test, diilanjutkan uji Univariate Linear Model untuk membandingkan kadar SOD antara electrical stunning dan tanpa electrical stunning pada fase pre dan post perlakuan. Hasil Shapiro-Wilk Test dengan diagram Q-Q plot menunjukkan pola distribusi normal pada semua perlakuan. Kelompok electrical stunning menunjukkan penurunan signifikan SOD. Kadar SOD yang rendah tampak signifikan juga pada pre perlakuan dibandingkan dengan post perlakuan. Dapat disimpulkan terdapat penurunan signifikan SOD pada serum babi Landrace Crossbred yang mendapat electrical stunning sebelum penyembelihan.
Noospheric Vocation of Greater Eurasia in the XXI Century
Authors: Subetto A. I. , Shamakhov V. A.
Published: January 2021

The article reveals the theoretical position on the noospheric vocation of “Greater Eurasia” in the 21st century. Opposition to the “Big West” as a global imperialism system of the world financial capitalocracy on the part of Greater Eurasia acquires a noospheric and socialist “dimension” in the 21st century. Russia is called upon to head the Noosphere Breakthrough of humanity in the XXI century, as a Eurasian civilization, occupying an important place in the Greater Eurasia’s structure, and as the birthplace of the socialism first appearance in the world and the doctrine of the Biosphere transition into the Noosphere by V. I. Vernadsky, and as a center of stability and instability in the world. Greater Eurasia is called upon to become the “locomotive” of noospheresocialist transformations of the human existence foundations. The alternative to this is the death of mankind, which is market-capitalistic for reasons and ecological for foundations.
The Identity of the Russian Federation in the Framework of the Presidential Addresses to the Federal Assembly
Authors: Tikhonov V. G.
Published: January 2021

The article is based on content and discourse analysis of the addresses of the President of the Russian Federation to the Federal Assembly dated 12/01/2016, 03/01/2018, 02/20/2019, 01/15/2020. The aim of research is to analyze the concept of identity in the framework of Presidential Addresses and changes in the concepts of identity in dynamics. The general tendencies of considering the term “identity” in the framework of determining the identity of the Russian Federation are derived. The special relationship between the identity of the Russian Federation and the integration of the Russian Federation into integration spaces is considered. The Vladimir Putin’s statements regarding the integration of the Russian Federation into the Eurasian Economic Union are evaluated, since the Russian Federation identity, in the opinion of the President, is inextricably linked with the formation of the “Eurasian identity of the Russian Federation”, which in turn determines the direct relationship between the identity of the Russian Federation and the integration of the Russian Federation into the Eurasian Economic Union. The article defines the subjective factor of the Russian President, which reflects the personal nature of the President’s orders and proposals. The dynamics of changes in the formation of the Russian Federation identity is reflected according to the addresses of the President of the Russian Federation to the Federal Assembly, and also on the basis of the dynamics of changes in the identity of the Russian Federation, the general process orientation of developing the Russian Federation identity is reflected. The article characterizes the permanent nature of the formation of the identity of Russia. Now, the identity of Russia is perceived as a special construct that reflects the special position of the Russian Federation, both in historical development and in the international arena.
Eurasian Vector of Foreign Policy of the Republic of Korea: the Factor of Central Asia
Authors: Bulanakova M. A.
Published: January 2021

The article studies the role of cooperation between the Republic of Korea and Central Asian countries in the context of a continental strategy for Korea’s New Northern policy. The authors consider the main political discourses of the continental policy of the Republic of Korea, such as the problem of resolving the “Korean issue”, the problem of balancing interests in the East Asian region, and the problem of diversifying traditional partnerships. Korea’s foreign policy is interpreted within the framework of the “middle power” concept. An important part of the study is the analysis of cooperation between RoK and Central Asia both on a multilateral and bilateral basis. It is obvious that uneven two-way interaction of Korea with the Central Asian countries, encourages the RoK to implement specific projects relevant to the partners, at the same time, the RoK uses multilateral cooperation, to predict the cooperation prospects in the most relevant areas of cooperation — health, environment, digital policy. Attracting data of the current situation in the region and the world, the author notes important changes in the foreign policy of RoK, first of all, the ODA strengthening as an important tool for strengthening Korea in a specific region, as an important resource for solving problems of the pandemic COVID-19 impact. As the research result, the author comes to the conclusion that the implementation of the Eurasian vector in Korea’s foreign policy is a natural and necessary condition for the further development of Korea as a regional and global player. Cooperation with Central Asia is a priority resource for developing RoK’s international influence and an important component of the new Northern policy.
О приближении средними Фейера классов аналитических периодических функций
Authors: Ровенская Ольга Геннадиевна , Новиков Олег Александрович
Published: January 2021

Работа посвящена вопросам приближения периодических функций высокой гладкости средними арифметическими сумм Фурье. Наиболее естественным и простым примером линейного процесса аппроксимации периодических непрерывных функций действительной переменной является приближение елементами последовательности частичных сумм ряда Фурье. Известно, что последовательности частичных сумм ряда Фурье не являются равномерно сходящимися на всем пространстве $C$ $2\pi$-периодических непрерывных функций. Поэтому значительное число работ данного направления посвящено изучению аппроксимативных свойств других методов приближения, которые для заданной функции $f$ образуются с помощью некоторых преобразований частичных сумм ее ряда Фурье, и позволяют построить последовательности тригонометрических полиномов, которые равномерно сходятся для каждой функции $f \in C$. В частности, на протяжении последних десятилетий интенсивно изучаются суммы Валле Пуссена и суммы Фейера. В настоящее время в публикациях этой тематики накоплено значительное количество фактического материала. Одним из наиболее важных направлений в этой области является изучение асимптотического поведения верхних граней уклонений средних арифметических сумм Фурье по различным классам периодических функций. Методы исследования интегральных представлений уклонений тригонометрических полиномов, которые порождаются линейными методами суммирования рядов Фурье, возникли и получили свое развитие в работах С.М.~Никольского, С.Б.~Стечкина, Н.П.~Корнейчука, В.К. Дзядыка и их учеников.

Целью работы является систематизация известных результатов, касающихся приближения классов периодических функций высокой гладкости средними арифметическими сумм Фурье, и представление новых фактов, полученных для их частных случаев.

В работе изучено аппроксимативные свойства сумм Фейера на классах периодических функций, которые можно регулярно продолжить в соответствующую полосу комплексной плоскости. Получена асимптотическая формула для верхних граней уклонений в равномерной метрике сумм Фейера на классах интегралов Пуассона. Полученная формула обеспечивает решение соответствующей задачи Колмогорова-Никольского без дополнительных условий.
Арифметические свойства элементов прямых произведений p-адических полей
Authors: Самсонов Алексей Сергеевич
Published: January 2021

В статье рассматриваются вопросы трансцендентности и алгебраической независимости,формулируются и доказываются теоремы длянекоторых элементов прямых произведений $p$-адических полей, а также,теорема об оценке многочлена от таких элементов.Пусть $\mathbb{Q}_p$~--- пополнение $\mathbb{Q}$ по$p$-адической норме, поле $\Omega_{p}$~--- пополнение алгебраического замыкания $\mathbb{Q}_p$,$g=p_1p_2\ldots p_n$~--- произведение различных простых чисел,а пополнение $\mathbb{Q}$ по $g$-адической псевдонормеэто кольцо $\mathbb{Q}_g$, иными словами $\mathbb{Q}_{p_1}\oplus\ldots\oplus\mathbb{Q}_{p_n}$.Рассматривается кольцо $\Omega_g\cong\Omega_{p_1}\oplus\ldots\oplus\Omega_{p_n}$,содержащее $\mathbb{Q}_g$ в качестве подкольца. Вопросы о трансцендентности и алгебраическойнезависимости над $\mathbb{Q}_g$ элементов $\Omega_g$ привели к результатам полученным в статье.При соблюдении некоторых условий можно делать соответствующие выводы для чисел вида$\alpha=\sum\limits_{j=0}^{\infty}a_{j}g^{r_{j}},\;\text{где}\;a_{j}\in \mathbb Z_g,$а неотрицательные рациональные числа $r_{j}$ образуют возрастающую истремящуюся к $+\infty$ при $j\rightarrow +\infty$ последовательность.
Константы Никольского — Бернштейна в $L^p$ на сфере с весом Данкля
Authors: Горбачев Дмитрий Викторович , Николаевич Добровольский Николай
Published: January 2021

Изучаются точные константы Никольского--Бернштейна для сферических полиномов впространстве $L^{p}(\mathbb{S}^{d})$ с весом Данкля. Устанавливаетсявзаимосвязь с одномерными константами для алгебраических полиномов впространстве $L^{p}[-1,1]$ с весом Гегенбауэра.
Метафизика Московской математической школы на рубеже XIX–XX веков
Authors: Мельников Роман Анатольевич , Саввина Ольга Алексеевна
Published: January 2021

В данной работе рассматривается вопрос о формировании религиозных воззрений упредставителей Московской математической школы на рубеже XIX–XX вв. и влиянии ми-росозерцания на их научное творчество. Основное ядро этой группы ученых составлялиН.Д. Брашман, Н.В. Бугаев, П.А. Некрасов, Д.Ф. Егоров, Н.Н. Лузин, П.А. Флоренский.В эволюции идей московских математиков-мыслителей XIX – начала XX века мож-но выделить общую тенденцию: они прошли путь от математики к философии и сно-ва вернулись к математике. Из Московского математического общества (Н.Д. Брашман,Н.В. Бугаев и др.) выросла Московская философско-математическая школа (Н.В. Бугаев,П.А. Некрасов, П.А. Флоренский и др.), а последняя послужила импульсом к образованиюМосковской школы теории функций (Д.Ф. Егоров, Н.Н. Лузин и др.).Впервые выявлены мировоззренческие истоки формирования Московской математиче-ской школы. Философские предпочтения представителей этой школы близки к славяно-фильству (неприятие развития России по западным образцам, учение о цельности духа(отрицающее познание только через разум или чувства без участия духа); учение о собор-ности как получении свободы через растворение личности в церкви, обществе, государстве;православное миропонимание; любовь к Родине). Эти идеи оказали влияние и на характерматематического творчества московских математиков, специфическими чертами которогостали: 1) коллективный характер, генерирование новых направлений в науке и горячее же-лание делиться ими с другими учеными; 2) сосредоточенность на поиске общих методов изакономерностей; 3) склонность к созерцанию, предпочтение теоретических исследований,а не практических (область научных интересов — теория чисел, теория множеств, теорияфункций и пр.).
Рассеяние наклонно падающей плоской звуковой волны упругим цилиндром с неоднородным покрытием, находящимся вблизи плоской поверхности
Authors: Толоконников Лев Алексеевич , Юрьевич Ефимов Дмитрий
Published: January 2021

В статье рассматривается задача о рассеянии плоской монохроматической звуковой волны, падающей произвольным образом на упругий круговой цилиндр с радиальнонеоднородным покрытием в присутствии плоской поверхности (абсолютно жесткой и акустически мягкой). Методом мнимых источников с применением теорем сложения для цилиндрических волновых функций получено аналитическое решение задачи. Волновые поля в содержащей среде и однородном упругом цилиндре находятся в виде разложений по волновым цилиндрическим функциям, а для нахождения полей смещений в неоднородных покрытиях построена краевая задача для системы обыкновенных дифференциальных уравнений второго порядка.Проведены численные расчеты частотных и угловых характеристик рассеянного поля для упругих однородных цилиндров с покрытием и без него, находящихся вблизи подстилающей плоскости. Выявлено существенное влияние непрерывно-неоднородных упругих покрытий на звукоотражающие свойства упругих цилиндрических тел.
Весовые неравенства для преобразований Данкля — Рисса и градиента Данкля
Authors: Иванов Валерий Иванович
Published: January 2021

В пространствах с весом Данкля степенного типа на $\mathbb{R}^d$ за последние 30 лет построен содержательный гармонический анализ. Классический анализ Фурье на евклидовом пространстве соответствует безвесовому случаю. В гармоническом анализе Данкля важную роль играют преобразования Данкля--Рисса и потенциал Данкля--Рисса, определенные Тангавелу и Шу. В частности, они позволяют доказывать неравенства Соболева для градиента Данкля. Частные результаты здесь были получены Амри и Сифи, Абделькефи и Рачди, Велику. Опираясь на весовые неравенства для потенциала Данкля--Рисса и преобразований Данкля--Рисса, мы доказываем общие $(L^q,L^p)$-неравенства Соболева для градиента Данкля с радиальными степенными весами. Весовые неравенства для потенциала Данкля--Рисса были установлены ранее. $L^p$-неравенства для преобразований Данкля--Рисса с радиальным степенным весом устанавливаются в настоящей работе. Безвесовой вариант этих неравенств был доказан Амри и Сифи.
UTILIZAÇÃO DE MICRORGANISMO AUTÓGENO PARA A RECUPERAÇÃO DE FISSURAS EM CORPOS DE PROVA DE ARGAMASSA
Authors: Mânica Graciela , Volken de Souza Claucia Fernanda
Published: January 2021

A utilização de microrganismos precipitantes de carbonato de cálcio ou calcita (CaCO3) vem sendo proposta como uma alternativa para solucionar os problemas de fissuração dos materiais cimentícios sem interferir nas suas propriedades. Para adicionar os microrganismos à mistura e garantir sua sobrevivência no meio alcalino é recomendado envolvê-los em uma cápsula, juntamente com os nutrientes necessários para que ocorra a precipitação do CaCO3. Nesse contexto o objetivo desse trabalho foi induzir a autocicatrização de corpos de prova (CPs) de argamassa, utilizando um microrganismo precipitante do CaCO3, encapsulado com alginato de sódio e com alginato de sódio e amido combinados. O microrganismo utilizado foi o Bacillus subtilis ATCC6633 que foi encapsulado por meio de extrusão. O microrganismo foi adicionado, de forma livre e encapsulado, aos corpos de prova de concreto que tiveram as fissuras induzidas por aplicação de esforço de flexão. Após, os corpos de prova foram mergulhados em água e em água com ureia para ativação do microrganismo e, posteriormente, observou-se a recuperação das fissuras. As amostras contendo o microrganismo, encapsulado ou livre, foram comparadas aos corpos de prova de referência, onde o mesmo não foi adicionado. Ao final do período de cem dias observou-se a cicatrização das fissuras nos CPs contendo microrganismo encapsulado. Não foi verificada diferença de cicatrização entre os CPs mergulhados em água e água com ureia. Os resultados obtidos indicam a viabilidade da utilização de microrganismo autógeno para a cicatrização de fissuras em corpos de prova de argamassa.
AUTOM8 - FERRAMENTA WEB PARA GERENCIAMENTO, MANUTENÇÃO E ATUALIZAÇÃO REMOTA DE SISTEMAS OPERACIONAIS E APLICATIVOS
Authors: Gasparini Heryk , Pretto Fabrício
Published: January 2021

A gestão e o controle das estações de rede segundo os conceitos da governança da TI e da gerência de redes de computadores, permitem a uma organização alcançar maior eficiência na gestão de recursos de TI. As soluções disponíveis no mercado para o gerenciamento de estações de rede por meio de um software possuem um alto valor financeiro. A necessidade de manutenção de software e hardware é frequente e exige monitoramento e correções de falhas. O gerenciamento remoto permite aos profissionais e departamentos de TI realizar manutenções preventivas e corretivas de forma eficiente. Este trabalho apresenta o desenvolvimento de uma ferramenta composta por uma aplicação web, chamada de gerente, e uma aplicação cliente, instalada nas estações atuando como um agente de rede para realizar a comunicação entre os sistemas. O intuito do desenvolvimento da solução é otimizar os recursos e processos de gerenciamento, manutenção e atualização remota de software operacional e aplicativo de estações de rede. A solução desenvolvida permite fazer a gestão de estações de rede de forma remota e eficiente. Através do acompanhamento dos registros e criação de tarefas automatizadas, a aplicação web coordena a execução na aplicação cliente instalada nas estações de rede.
A UTILIZAÇÃO DE METODOLOGIAS ATIVAS NOS CURSOS DO CENTRO DE EDUCAÇÃO PROFISSIONAL DA UNIVERSIDADE DO VALE DO TAQUARI - UNIVATES
Authors: Scheibel Daniela Luisa , Schorr Maria Claudete
Published: January 2021

As metodologias ativas são técnicas inovadoras, que contribuem de forma significativa no processo de ensino e aprendizagem, as mesmas estão sendo bastante discutidas e implementadas nos planos de aula. São propostas educacionais que desenvolvem o processo de aprender, estratégias que trazem benefícios, tanto para os professores quanto para os alunos. Estes métodos fazem com que os alunos tenham uma postura ativa frente ao seu aprendizado, enquanto os docentes assumem o papel de orientador e mediador. Desta forma, o presente estudo teve como objetivo, verificar se as metodologias ativas estão sendo executadas nos dezessete cursos, oferecidos pela Educação Profissional da Universidade do Vale do Taquari - Univates, através de uma pesquisa qualitativa e quantitativa. O levantamento de dados foi processado por meio de dois questionários elaborados no Google Forms, sendo um para professores e um para alunos. A pesquisa foi realizada com 41 professores e 197 alunos. Com as informações, foi possível identificar que a utilização das metodologias ativas, que tem por finalidade, contribuir com o ensino e aprendizagem, são fundamentais para acompanhar a nova geração de alunos e que, já estão sendo adotadas por parte de alguns professores, mas que o aprimoramento destas estratégias não deve cessar, a busca pela qualificação deve ser constante.
ESTIMATIVA TEÓRICA DO POTENCIAL DE GERAÇÃO DE ENERGIA ELÉTRICA A PARTIR DE CANA-DE-AÇÚCAR, CAPIM ELEFANTE E COCO DA BAHIA NO BRASIL
Authors: Martins Luís Oscar Silva , De Andrade Digo Alex Santos
Published: January 2021

Os atuais problemas de fornecimento de energia associados à conscientização sobre as mudanças climáticas têm motivado a academia a pesquisar fontes renováveis de combustíveis e a dedicar maiores esforços ao estudo de sua eficiência energética e impactos socioambientais. Dentre as fontes energéticas de origem renovável, a biomassa se apresenta de forma promissora. Engloba, entre outros, vegetação, cultivos energéticos, bem como biossólidos, resíduos animais, florestais e agrícolas, a fração orgânica de resíduos urbanos e certos tipos de resíduos industriais. Nesse sentido, este estudo apresenta uma análise preliminar do potencial de geração de energia elétrica a partir de biomassa vegetal provenientes de diferentes regiões brasileiras. Foram analisados os resíduos derivados da cana-de-açúcar, coco-da-baía e a gramínea capim elefante. A partir dos valores de suas safras, referentes à 2017/2018, juntamente com os valores dos poderes caloríficos inferiores pesquisados junto à literatura pertinente, foram construídos mapas temáticos, que demonstraram o potencial teórico de geração de eletricidade das culturas. Os resultados demonstraram que, para a cana, cujo estágio de desenvolvimento e utilização já estão consolidados, ainda existe espaço para exploração. O capim elefante apresentou alto potencial e capacidade de crescimento, enquanto que o coco-da-baía pode ser uma alternativa energética, especialmente para o Nordeste, apesar dos problemas relacionados a umidade deste último.
Congenital Unilateral Absence of the Vas Deferens with Ipsilateral Renal Agenesis encountered during Laparoscopic Totally Extraperitoneal Inguinal Hernia Repair in an Adult Patient: A Case Report
Authors: Smeyers Karel , Hutting Kor , Hofmeester Ilse , Reine Robert Prudhomme van
Published: January 2021

We report the first incidental finding of congenital unilateral absence
of the vas deferens and ipsilateral renal agenesis during endoscopic
totally extraperitoneal inguinal hernia repair. The absence of the vasa
deferentia occurs unilateral, associated with renal anomalies, or
bilateral which has a genetic link to cystic fibrosis.
Minimally-invasive coronary artery bypass grafting offers superior outcomes compared to conventional median sternotomy: a propensity-score matched study
Authors: Wu Duoduo , Ong Zhi Xian , Luo Haidong , Chang GuoHao , Sazzad Faizus , Sule Jai , Hu Peggy , Kofidis Theo
Published: January 2021

Introduction This study aims to compare the outcomes of minimally
invasive coronary artery bypass grafting surgery (MICS CABG) versus
median sternotomy (MS CABG) within an established minimally invasive
cardiac surgical programme in Singapore. Methods We retrospectively
analysed 111 propensity-score matched pairs of patients who underwent
MICS CABG or MS CABG between January 2009 and February 2020 at the
National University Heart Centre, Singapore. Minimally invasive direct
coronary artery bypass (MIDCAB) patients were matched to single or
double graft MS CABG patients (Group 1) while multivessel MICS patients
were matched to MS CABG patients with the corresponding number of grafts
(Group 2). Results 111 propensity matched pairs were obtained. The
EuroSCORE II in the matched group cohorts were comparable (p=0.846). In
both single and multivessel groups, MICS patients experienced shorter
postoperative length of stay (p<0.001) and lower rates of
prolonged ventilation (p=0.041) . Intraoperative transfusion rates and
other postoperative outcomes were comparable between MICS and MS
patients in the single and multivessel groups.mortality, reintervention
heart failure rates were also comparable at 1 year follow up. In Group
1, no significant differences in procedural duration (p=0.574) and
cardiopulmonary bypass duration (p=0.699) were noted. Moreover, MIDCAB
patients had a smaller drop in postoperative haemoglobin levels
(p<0.001). In Group 2, cardiopulmonary bypass (p=0.097) and
length of procedure (p<0.001) were longer among multivessel
MICS patients but did not translate to adverse postoperative events.
Conclusion MICS CABG is a safe and effective approach for surgical
revascularisation of coronary artery disease.
Posterior Reversible Encephalopathy Syndrome Secondary to Asparaginase Associated Pancreatitis in Two Pediatric Patients with Acute Leukemia
Authors: Scheuermann Amanda , Harker-Murray Paul , Pommert Lauren
Published: January 2021

Asparaginase, a critical component of current pediatric acute leukemia
treatment protocols, is associated with a number of serious side
effects, one of which is pancreatitis. Pancreatitis can result in
significant morbidity and mortality from necrosis, pseudocyst formation,
hemorrhage, systemic inflammation, intestinal perforation and sepsis.
Another rare complication of pancreatitis is posterior reversible
encephalopathy syndrome (PRES), likely mediated by systemic inflammation
secondary to pancreatic autodigestion and pro-inflammatory
cytokine-mediated vascular endothelial damage. Here we review this
association in the literature and report two pediatric patients with
leukemia who developed PRES secondary to asparaginase-associated
pancreatitis.
Quantitative analysis of IKZF1 gene deletions in pediatric B-cell precursor acute lymphoblastic leukemia: Higher levels are associated with a poorer prognosis
Authors: Huang Zhizhuo , Jia Yueping , Ruan Guorui , Zuo Yingxi , Wu Jun , Lu Aidong , xue yujuan , Cheng Yifei , zhang leiping
Published: January 2021

Background: In pediatric B-cell precursor acute lymphoblastic leukemia
(BCP-ALL), the IKZF1 gene deletions is an molecular marker of poor
prognosis. We aimed to assess the prognostic effect of different levels
of IKZF1 gene deletions in pediatric BCP-ALL. Procedure: IKZF1 Δ2-8/ALB
deletions were quantified using multiplex real-time quantitative PCR
(RQ-PCR) in newly diagnosed pediatric BCP-ALL patients between June 2014
and January 2018. Seventy-four patients with IKZF1 deletions of ≥ 0.01%
were included. Clinical characteristics, laboratory data, and treatment
outcomes were analyzed. Results: The patients were divided into two
groups: IKZF1 deletions of < 1% (Group A) and of ≥ 1% (Group
B). Patients in group B had a higher BCR-ABL1 positive rate than those
in group A (P = 0.001). The proportions of patients who had an age at
onset of ≥10 years old, and white blood cell count ≥ 50×109/L were
significantly higher in group B than in group A (P < 0.05).
The 3-year overall survival (OS) and 3-year event-free survival (EFS)
rates in group B were 79 ± 8.8% and 62.4 ± 9.7%, respectively, which
were significantly lower than the 3-year OS (97.7 ± 2.2%, P = 0.022)
and 3-year EFS (83.2 ± 5.8%, P = 0.019) in group A. Multivariate
analysis revealed that the level of IKZF1 deletions of ≥ 1% and CNSL
were independent risk factors of EFS. Conclusions: Pediatric BCP-ALL
patients with high levels of IKZF1 gene deletions have a poorer
prognosis than those with low levels.
An effective computational-screening strategy for simultaneously improving both catalytic activity and thermostability of α-L-rhamnosidase
Authors: Li Lijun , Li Wenjing , Gong Jianye , Xu Yanyan , Wu Zheyu , Jiang Zedong , Cheng Yi-sheng , Li Qingbiao , Ni Hui
Published: January 2021

Catalytic efficiency and thermostability are the two most important
characteristics of enzymes. However, it is always tough to improve both
catalytic efficiency and thermostability of enzymes simultaneously. In
the present study, a computational strategy with double-screening steps
was proposed to simultaneously improve both catalysis efficiency and
thermostability of enzymes; and a fungal α-L-rhamnosidase was used to
validate the strategy. As the result, by molecular docking and sequence
alignment analysis within the binding pocket, seven mutant candidates
were predicted with better catalytic efficiency. By energy variety
analysis, three among the seven mutant candidates were predict with
better thermostability. The expression and characterization results
showed the mutant D525N had significant improvements in both enzyme
activity and thermostability. Molecular dynamics simulations indicated
that the mutations located within the 5 Å range of the catalytic domain,
which could improve RMSD, electrostatic, Van der Waal interaction and
polar salvation values, and formed water bridge between the substrate
and the enzyme. The study indicated that the computational strategy
based on the binding energy, conservation degree and mutation energy
analyses was effective to develop enzymes with better catalysis and
thermostability, providing practical approach for developing industrial
enzymes.
Unusual case of Large Right Atrial mass
Authors: V Bharath , Hote Milind
Published: January 2021

A 57-year female presented to emergency with features of right heart
failure. On evaluation, she was found to have a large mass completely
occupying right atrium and protruding into right ventricle through
tricuspid valve. Here we present the 3D reconstruction images and
intra-operative images of the RA mass.
A case of atrial septal defect associated with anomalous sinoatrial node artery in pulmonary atresia with intact ventricular septum
Authors: Candia Angela Di , CASTALDI BIAGIO , Sirico Domenico , Salvo Giovanni Di
Published: January 2021

An 11-year-old boy affected by pulmonary atresia with intact ventricular
septum (AP-IVS) was listed for percutaneous pulmonary valvuloplasty and
closure of multi-fenestrated atrial septal defect (ASD). Intraprocedural
transesophageal echocardiography arose the suspect of abnormal coronary
artery pattern while selective angiography documented a single
sinoatrial node artery (SANa) with an unusual retro-aortic course. As
consequence, we proceeded to effectively close the defects with a not
self-centering device placed in the most central side hole. This case
supports the hypothesis that sometimes arrhythmic complication during
ASD closure procedures might be due to unrecognized injury of the SANa.
Operna publika u digitalnom okruženju i operni online sadržaji tijekom karantene uzrokovane pandemijom bolesti COVID-19
Authors: Brgles Miriam Mary , Škender Dora
Published: January 2021

Rad je usmjeren na afirmaciju kvalitativnih istraživanja u grani sociologije
medija i sociologije kulture, a glavni cilj rada jest opisati kako operna publika
prati recentnu opernu produkciju, putem kojih digitalnih medija te koja joj je
motivacija i koja joj značenja pridaje. Iako trendovi socioloških istraživanja
kazališne publike u zapadnom svijetu podrazumijevaju proširivanje fokusa
istraživanja i na „ne-publiku“ (Tröndle, 2019), u Hrvatskoj nikada do sada nije
provedeno istraživanje operne i/ili koncertne publike, koja se u Austriji i
Njemačkoj zasebno istražuje. Sukladno promjeni paradigme, koja je potvrđena
u istraživanjima u SAD-u, istraživačka pitanja rada su: mogu li se prijenosi
opera uživo u kinima podrazumijevati kao kulturno događanje te može li se Dollaseova (1998) kategorizacija publike proširiti novom kategorijom, u koju pripada publika koja opere i operne sadržaje prati u kinima i(li) online, što je bila
jedina mogućnost tijekom karantene uzrokovane pandemijom bolesti COVID-19. Primijenjen je fenomenološki pristup i kvalitativna metodologija (metoda opažanja sa sudjelovanjem, četiri strukturirana intervjua i analiza sadržaja).
Istraživanje je pokazalo kako je uloga virtualnog prostora, iako drugačija i
obilježena specifičnim manjkavostima, gotovo jednako važna kao i fizički prostor u kojem se odvija socijalna interakcija operne publike. Publika stvarnost izvedbe opere, preseljene u virtualni prostor, shvaća i opisuje uglavnom s visokim interesima, motivacijom i očekivanjima. Također, besplatni online operni
sadržaji, koji su intenzivno zaživjeli u 2020. godini tijekom karantene uzrokovane pandemijom bolesti COVID-19, približavaju opernu umjetnost široj populaciji te se predlaže proširenje Dollaseove kategorizacije kategorijom digitalne
operne publike.
Nos tuis supplicationibus inclinati: Pope
Innocent IV and the Decline of Delegated Jurisdiction in Hungary in the Mid-13th
Century
Authors: Barabás Gábor
Published: January 2021

The paper discusses a special aspect of the
papal-Hungarian relations, namely the operation of delegated jurisdiction after
the Mongol invasion of 1241-42. The focus of the study is on the revival of the
system in the 1240s, and on certain measures of Pope Innocent IV in 1252 and
1254. The first measure of this kind is traditionally considered to be the
papal allowance granted to King Béla IV in order to avoid his ecclesiastical
and lay subjects being cited outside of the
realm. This prohibition, according to the opinion of the Hungarian legal
historian György Bónis, was annulled as early as 1259. In the present study, we
argue that, although the charters of Innocent IV and Alexander IV are indeed of
great importance, their impact should not be overrated. The number of known
cases supervised by the papal judges dropped significantly in the 1250s.
However, the reason behind this decrease cannot be solely explained by the
above-mentioned papal charter; other factors should also be considered in
investigating this question.
Integral Cayley graphs over semi-dihedral groups
Authors: Cheng Tao , Feng Lihua , Yu Guihai , Zhang Chi
Published: January 2021

Classifying integral graphs is a hard problem that initiated by Harary and
Schwenk in 1974. In this paper, with the help of character table, we treat
the corresponding problem for Cayley graphs over the semi-dihedral group
SD8n = ?a,b | a4n = b2 = 1, bab = a2n-1?, n ? 2. We present several
necessary and sufficient conditions for the integrality of Cayley graphs over
SD8n, we also obtain some simple sufficient conditions for the integrality of
Cayley graphs over SD8n in terms of the Boolean algebra of hai. In
particular, we give the sufficient conditions for the integrality of Cayley
graphs over semi-dihedral groups SD2n (n?4) and SD8p for a prime p, from
which we determine several infinite classes of integral Cayley graphs over
SD2n and SD8p.