bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 3 from RNF8 Regulates Assembly of RAD51 at DNA Double-Strand Breaks in the Absence of BRCA1 and 53BP1
Authors: Nakada Shinichiro , Yonamine Rikako Miyamoto , Matsuo Koichi
Published: April 2023

PDF file - 666K, RAD51 assembles at DSB sites in RNF8-/- MEFs
Supplementary Figure 2 from RNF8 Regulates Assembly of RAD51 at DNA Double-Strand Breaks in the Absence of BRCA1 and 53BP1
Authors: Nakada Shinichiro , Yonamine Rikako Miyamoto , Matsuo Koichi
Published: April 2023

PDF file - 108K, The effective knockdown of UBC13, RAP80 or RNF168 was confirmed using western blotting
Supplementary Figure 9 from Proangiogenic Factor PlGF Programs CD11b+ Myelomonocytes in Breast Cancer during Differentiation of Their Hematopoietic Progenitors
Authors: Laurent Julien , Hull Eveline Faes-van't , Touvrey Cedric , Kuonen François , Lan Qiang , Lorusso Girieca , Doucey Marie-Agnès , Ciarloni Laura , Imaizumi Natsuko , Alghisi Gian Carlo , Fagiani Ernesta , Zaman Khalil , Stupp Roger , Shibuya Masabumi , Delaloye Jean-François , Christofori Gerhard , Ruegg Curzio
Published: April 2023

Supplementary Figure 9 from Proangiogenic Factor PlGF Programs CD11b+ Myelomonocytes in Breast Cancer during Differentiation of Their Hematopoietic Progenitors
Supplementary Table S4 from LIN28B Polymorphisms Influence Susceptibility to Epithelial Ovarian Cancer
Authors: Permuth-Wey Jennifer , Kim Donghwa , Tsai Ya-Yu , Lin Hui-Yi , Chen Y. Ann , Barnholtz-Sloan Jill , Birrer Michael J. , Bloom Gregory , Chanock Stephen J. , Chen Zhihua , Cramer Daniel W. , Cunningham Julie M. , Dagne Getachew , Ebbert-Syfrett Judith , Fenstermacher David , Fridley Brooke L. , Garcia-Closas Montserrat , Gayther Simon A. , Ge William , Gentry-Maharaj Aleksandra , Gonzalez-Bosquet Jesus , Goode Ellen L. , Iversen Edwin , Jim Heather , Kong William , McLaughlin John , Menon Usha , Monteiro Alvaro N.A. , Narod Steven A. , Pharoah Paul D.P. , Phelan Catherine M. , Qu Xiaotao , Ramus Susan J. , Risch Harvey , Schildkraut Joellen M. , Song Honglin , Stockwell Heather , Sutphen Rebecca , Terry Kathryn L. , Tyrer Jonathan , Vierkant Robert A. , Wentzensen Nicolas , Lancaster Johnathan M. , Cheng Jin Q. , Sellers Thomas A.
Published: April 2023

Supplementary Table S4 from LIN28B Polymorphisms Influence Susceptibility to Epithelial Ovarian Cancer
Supplementary Figure 8 from Proangiogenic Factor PlGF Programs CD11b+ Myelomonocytes in Breast Cancer during Differentiation of Their Hematopoietic Progenitors
Authors: Laurent Julien , Hull Eveline Faes-van't , Touvrey Cedric , Kuonen François , Lan Qiang , Lorusso Girieca , Doucey Marie-Agnès , Ciarloni Laura , Imaizumi Natsuko , Alghisi Gian Carlo , Fagiani Ernesta , Zaman Khalil , Stupp Roger , Shibuya Masabumi , Delaloye Jean-François , Christofori Gerhard , Ruegg Curzio
Published: April 2023

Supplementary Figure 8 from Proangiogenic Factor PlGF Programs CD11b+ Myelomonocytes in Breast Cancer during Differentiation of Their Hematopoietic Progenitors
Supplementary Table S3 from LIN28B Polymorphisms Influence Susceptibility to Epithelial Ovarian Cancer
Authors: Permuth-Wey Jennifer , Kim Donghwa , Tsai Ya-Yu , Lin Hui-Yi , Chen Y. Ann , Barnholtz-Sloan Jill , Birrer Michael J. , Bloom Gregory , Chanock Stephen J. , Chen Zhihua , Cramer Daniel W. , Cunningham Julie M. , Dagne Getachew , Ebbert-Syfrett Judith , Fenstermacher David , Fridley Brooke L. , Garcia-Closas Montserrat , Gayther Simon A. , Ge William , Gentry-Maharaj Aleksandra , Gonzalez-Bosquet Jesus , Goode Ellen L. , Iversen Edwin , Jim Heather , Kong William , McLaughlin John , Menon Usha , Monteiro Alvaro N.A. , Narod Steven A. , Pharoah Paul D.P. , Phelan Catherine M. , Qu Xiaotao , Ramus Susan J. , Risch Harvey , Schildkraut Joellen M. , Song Honglin , Stockwell Heather , Sutphen Rebecca , Terry Kathryn L. , Tyrer Jonathan , Vierkant Robert A. , Wentzensen Nicolas , Lancaster Johnathan M. , Cheng Jin Q. , Sellers Thomas A.
Published: April 2023

Supplementary Table S3 from LIN28B Polymorphisms Influence Susceptibility to Epithelial Ovarian Cancer
Supplementary Figure 7 from Proangiogenic Factor PlGF Programs CD11b+ Myelomonocytes in Breast Cancer during Differentiation of Their Hematopoietic Progenitors
Authors: Laurent Julien , Hull Eveline Faes-van't , Touvrey Cedric , Kuonen François , Lan Qiang , Lorusso Girieca , Doucey Marie-Agnès , Ciarloni Laura , Imaizumi Natsuko , Alghisi Gian Carlo , Fagiani Ernesta , Zaman Khalil , Stupp Roger , Shibuya Masabumi , Delaloye Jean-François , Christofori Gerhard , Ruegg Curzio
Published: April 2023

Supplementary Figure 7 from Proangiogenic Factor PlGF Programs CD11b+ Myelomonocytes in Breast Cancer during Differentiation of Their Hematopoietic Progenitors
Supplementary Table S2 from LIN28B Polymorphisms Influence Susceptibility to Epithelial Ovarian Cancer
Authors: Permuth-Wey Jennifer , Kim Donghwa , Tsai Ya-Yu , Lin Hui-Yi , Chen Y. Ann , Barnholtz-Sloan Jill , Birrer Michael J. , Bloom Gregory , Chanock Stephen J. , Chen Zhihua , Cramer Daniel W. , Cunningham Julie M. , Dagne Getachew , Ebbert-Syfrett Judith , Fenstermacher David , Fridley Brooke L. , Garcia-Closas Montserrat , Gayther Simon A. , Ge William , Gentry-Maharaj Aleksandra , Gonzalez-Bosquet Jesus , Goode Ellen L. , Iversen Edwin , Jim Heather , Kong William , McLaughlin John , Menon Usha , Monteiro Alvaro N.A. , Narod Steven A. , Pharoah Paul D.P. , Phelan Catherine M. , Qu Xiaotao , Ramus Susan J. , Risch Harvey , Schildkraut Joellen M. , Song Honglin , Stockwell Heather , Sutphen Rebecca , Terry Kathryn L. , Tyrer Jonathan , Vierkant Robert A. , Wentzensen Nicolas , Lancaster Johnathan M. , Cheng Jin Q. , Sellers Thomas A.
Published: April 2023

Supplementary Table S2 from LIN28B Polymorphisms Influence Susceptibility to Epithelial Ovarian Cancer
Supplementary Figure 1 from Proangiogenic Factor PlGF Programs CD11b+ Myelomonocytes in Breast Cancer during Differentiation of Their Hematopoietic Progenitors
Authors: Laurent Julien , Hull Eveline Faes-van't , Touvrey Cedric , Kuonen François , Lan Qiang , Lorusso Girieca , Doucey Marie-Agnès , Ciarloni Laura , Imaizumi Natsuko , Alghisi Gian Carlo , Fagiani Ernesta , Zaman Khalil , Stupp Roger , Shibuya Masabumi , Delaloye Jean-François , Christofori Gerhard , Ruegg Curzio
Published: April 2023

Supplementary Figure 1 from Proangiogenic Factor PlGF Programs CD11b+ Myelomonocytes in Breast Cancer during Differentiation of Their Hematopoietic Progenitors
Supplementary Methods, Table 1, Figures 1-8 from Genetic Deficiency in Plasma Protein HRG Enhances Tumor Growth and Metastasis by Exacerbating Immune Escape and Vessel Abnormalization
Authors: Tugues Sònia , Honjo Satoshi , König Christian , Noguer Oriol , Hedlund Marie , Botling Johan , Deschoemaeker Sofie , Wenes Mathias , Rolny Charlotte , Jahnen-Dechent Wilhelm , Mazzone Massimiliano , Claesson-Welsh Lena
Published: April 2023

PDF file - 168K
Supplementary Figures Legends 1-2, Methods from S-Glutathionylated Serine Proteinase Inhibitors as Plasma Biomarkers in Assessing Response to Redox-Modulating Drugs
Authors: Grek Christina L. , Townsend Danyelle M. , Uys Joachim D. , Manevich Yefim , Coker Woodrow J. , Pazoles Christopher J. , Tew Kenneth D.
Published: April 2023

PDF file - 84K
Supplementary Figure 1 from Interstitial Fluid Pressure and Associated Lymph Node Metastasis Revealed in Tumors by Dynamic Contrast-Enhanced MRI
Authors: Hompland Tord , Ellingsen Christine , Øvrebø Kirsti Marie , Rofstad Einar K.
Published: April 2023

PDF file - 25K, Figure showing IFP and v0 versus tumor size for TS-415 and U-25 tumors
Supplementary Table 2 from Transition from Colitis to Cancer: High Wnt Activity Sustains the Tumor-Initiating Potential of Colon Cancer Stem Cell Precursors
Authors: Shenoy Anitha K. , Fisher Robert C. , Butterworth Elizabeth A. , Pi Liya , Chang Lung-Ji , Appelman Henry D. , Chang Myron , Scott Edward W. , Huang Emina H.
Published: April 2023

PDF file - 102K, Tumorigenic potential of Wnt(high) vs Wnt(low) cells derived from pCCSCs and CCSCs in primary passage
Supplementary Methods from Transition from Colitis to Cancer: High Wnt Activity Sustains the Tumor-Initiating Potential of Colon Cancer Stem Cell Precursors
Authors: Shenoy Anitha K. , Fisher Robert C. , Butterworth Elizabeth A. , Pi Liya , Chang Lung-Ji , Appelman Henry D. , Chang Myron , Scott Edward W. , Huang Emina H.
Published: April 2023

PDF file - 120K, Supplementary methods include information on Wnt reporter and beta-Catenin shRNA knockdown constructs, real-time PCR, tumor dissociation, FACS, immunostaining and western blotting
Supplementary Figure Legends 1-8 from Transition from Colitis to Cancer: High Wnt Activity Sustains the Tumor-Initiating Potential of Colon Cancer Stem Cell Precursors
Authors: Shenoy Anitha K. , Fisher Robert C. , Butterworth Elizabeth A. , Pi Liya , Chang Lung-Ji , Appelman Henry D. , Chang Myron , Scott Edward W. , Huang Emina H.
Published: April 2023

PDF file - 104K
Supplementary Figure Legends from Gliomagenesis Arising from Pten- and Ink4a/Arf-Deficient Neural Progenitor Cells Is Mediated by the p53-Fbxw7/Cdc4 Pathway, Which Controls c-Myc
Authors: Kim Hong Sug , Woolard Kevin , Lai Chen , Bauer Peter O. , Maric Dragan , Song Hua , Li Aiguo , Kotliarova Svetlana , Zhang Wei , Fine Howard A.
Published: April 2023

PDF file, 109K
Supplementary Figure 8 from Transition from Colitis to Cancer: High Wnt Activity Sustains the Tumor-Initiating Potential of Colon Cancer Stem Cell Precursors
Authors: Shenoy Anitha K. , Fisher Robert C. , Butterworth Elizabeth A. , Pi Liya , Chang Lung-Ji , Appelman Henry D. , Chang Myron , Scott Edward W. , Huang Emina H.
Published: April 2023

PDF file - 383K, Proposed CCSC hierarchy in CAC
Supplementary Figure 6 from Transition from Colitis to Cancer: High Wnt Activity Sustains the Tumor-Initiating Potential of Colon Cancer Stem Cell Precursors
Authors: Shenoy Anitha K. , Fisher Robert C. , Butterworth Elizabeth A. , Pi Liya , Chang Lung-Ji , Appelman Henry D. , Chang Myron , Scott Edward W. , Huang Emina H.
Published: April 2023

PDF file - 857K, Primary CT-2 ALDH(high)-Wnt(low) tumor xenografts creates a phenocopy of an ALDH(high)-Wnt(high) tumor xenografts
Supplementary Figure 2 from Transition from Colitis to Cancer: High Wnt Activity Sustains the Tumor-Initiating Potential of Colon Cancer Stem Cell Precursors
Authors: Shenoy Anitha K. , Fisher Robert C. , Butterworth Elizabeth A. , Pi Liya , Chang Lung-Ji , Appelman Henry D. , Chang Myron , Scott Edward W. , Huang Emina H.
Published: April 2023

PDF file - 1.2MB, FACS profile and experimental overview
Supplementary Figure 1 from Transition from Colitis to Cancer: High Wnt Activity Sustains the Tumor-Initiating Potential of Colon Cancer Stem Cell Precursors
Authors: Shenoy Anitha K. , Fisher Robert C. , Butterworth Elizabeth A. , Pi Liya , Chang Lung-Ji , Appelman Henry D. , Chang Myron , Scott Edward W. , Huang Emina H.
Published: April 2023

PDF file - 3.7MB, Levels of Wnt/beta-catenin signaling in normal, colitis and CRC colons
Supplementary Table 1 from Neuropilin-1 Identifies a Subset of Bone Marrow Gr1− Monocytes That Can Induce Tumor Vessel Normalization and Inhibit Tumor Growth
Authors: Carrer Alessandro , Moimas Silvia , Zacchigna Serena , Pattarini Lucia , Zentilin Lorena , Ruozi Giulia , Mano Miguel , Sinigaglia Milena , Maione Federica , Serini Guido , Giraudo Enrico , Bussolino Federico , Giacca Mauro
Published: April 2023

PDF file - 91K, Supplementary Table 1. List of genes analyzed for expression by real-time, quantitative RT-PCR. All the amplifications were performed on a 7000 ABI Prism Instrument (Applied Biosystems), using pre-developed assays ("Mm" code), custom assays (for CCL5 and CXCR4) (Applied Biosystems) or SYBR Green (for Gr-1 and HPRT). The housekeeping genes GAPDH and HPRT were used to normalize the results.
Supplementary Figure Legend from Neuropilin-1 Identifies a Subset of Bone Marrow Gr1− Monocytes That Can Induce Tumor Vessel Normalization and Inhibit Tumor Growth
Authors: Carrer Alessandro , Moimas Silvia , Zacchigna Serena , Pattarini Lucia , Zentilin Lorena , Ruozi Giulia , Mano Miguel , Sinigaglia Milena , Maione Federica , Serini Guido , Giraudo Enrico , Bussolino Federico , Giacca Mauro
Published: April 2023

PDF file - 42K
Supplementary Figure 6 from Neuropilin-1 Identifies a Subset of Bone Marrow Gr1− Monocytes That Can Induce Tumor Vessel Normalization and Inhibit Tumor Growth
Authors: Carrer Alessandro , Moimas Silvia , Zacchigna Serena , Pattarini Lucia , Zentilin Lorena , Ruozi Giulia , Mano Miguel , Sinigaglia Milena , Maione Federica , Serini Guido , Giraudo Enrico , Bussolino Federico , Giacca Mauro
Published: April 2023

PDF file - 1214K, Levels of expression of HIF-1 target genes in tumors inoculated with bone marrow Gr1+ cells or NEMs. Quantification of the mRNA levels of the indicated factors (VEGF-A, Angiopoietin-2 and Interleukin-6) was obtained by real-time PCR. The results are shown after normalization for the GAPDH gene. Data are mean �s.e.m. **=P<0.01; *=P<0.05.
Supplementary Figure 4 from Neuropilin-1 Identifies a Subset of Bone Marrow Gr1− Monocytes That Can Induce Tumor Vessel Normalization and Inhibit Tumor Growth
Authors: Carrer Alessandro , Moimas Silvia , Zacchigna Serena , Pattarini Lucia , Zentilin Lorena , Ruozi Giulia , Mano Miguel , Sinigaglia Milena , Maione Federica , Serini Guido , Giraudo Enrico , Bussolino Federico , Giacca Mauro
Published: April 2023

PDF file - 3482K, Proliferative activity of 4T1 tumors in vivo. A. Immunofluorescence staining of frozen tumor sections from mice injected with PBS, Gr1+ cells or NEMs using an antibody against PCNA (red); nuclei are counterstained in blue with DAPI. Analysis was performed after the animal sacrifice at day 18 after tumor inoculation. Scale bar: 100 �m. B. Quantitative analysis showing the percentage of PCNA+ nuclei in the tumor sections. Data are mean�s.e.m.; n=5 per group.
Supplementary Table 1 from The CRTC1-NEDD9 Signaling Axis Mediates Lung Cancer Progression Caused by LKB1 Loss
Authors: Feng Yan , Wang Ye , Wang Zuoyun , Fang Zhaoyuan , Li Fei , Gao Yijun , Liu Hongyan , Xiao Tian , Li Fuming , Zhou Yang , Zhai Qiwei , Liu Xiaolong , Sun Yihua , Bardeesy Nabeel , Wong Kwok-kin , Chen Haiquan , Xiong Zhi-qi , Ji Hongbin
Published: April 2023

PDF file - 139K, The list of primers used in this study
Supplementary Figures 1-7, Tables 1-3 from SpliceArray Profiling of Breast Cancer Reveals a Novel Variant of NCOR2/SMRT That Is Associated with Tamoxifen Resistance and Control of ERα Transcriptional Activity
Authors: Zhang Luduo , Gong Chun , Lau Samantha L.Y. , Yang Nan , Wong Oscar G.W. , Cheung Annie N.Y. , Tsang Janice W.H. , Chan Kelvin Y.K. , Khoo Ui-Soon
Published: April 2023

PDF file - 2.2MB, Supplementary figure 1. IC 50 shows that AK47 is more resistant than its parental cell line ZR-75-1, although response to tamoxifen treatment was still observed. Supplementary figure 2. Heat map of 11 splice variants selected for further q-PCR validation Supplementary figure 3. BQ323636.1 was over-expressed in 293T and Hela cell lines to prove its predicted molecular weight Supplementary figure 4. In ER positive patients who have received tamoxifen treatment, BQ mRNA expression level is not significantly correlated with chest wall/breast relapse. Supplementary figure 5. BQ mRNA level and BQ/WT ratio correlates with ER and PR status while BQ/WT ratio correlates with "triple-negative" status. Supplementary figure 6. Schematic representation of the functional domains of NCOR2 wild type and variant BQ323636.1 and the amino acid sequence similarity of NCOR2 among different species. Supplementary figure 7. Schematic illustration showing the postulated dominant negative inhibitory effect of splice variant BQ323636.1 on the co-repressor function of NCOR2 wild type for ER� transcriptional activity. Supplementary table 1. Brest cancer cell lines used in SpliceArray profiling, and summary of the TaqMan real time qPCR validation results. Supplementary table 2. Primer and Taqman probe sequences used in qPCR validation Supplementary table 3. The correlation between BQ mRNA level, BQ/WT ratio and various clinical pathological parameters
Supplementary Figures 1-12 from The CRTC1-NEDD9 Signaling Axis Mediates Lung Cancer Progression Caused by LKB1 Loss
Authors: Feng Yan , Wang Ye , Wang Zuoyun , Fang Zhaoyuan , Li Fei , Gao Yijun , Liu Hongyan , Xiao Tian , Li Fuming , Zhou Yang , Zhai Qiwei , Liu Xiaolong , Sun Yihua , Bardeesy Nabeel , Wong Kwok-kin , Chen Haiquan , Xiong Zhi-qi , Ji Hongbin
Published: April 2023

PDF file - 307K, Supplementary Figure S1. Ectopic NEDD9 expression partially reverses the inhibitory function of LKB1 upon cell migration and invasion of human lung cancer cells. Supplementary Figure S2. shNedd9 inhibits lung cancer progression in de novo KrasG12D, Lkb1L/L mouse model. Supplementary Figure S3. NEDD9 promotes lung cancer progression in de novo KrasG12D mouse model. Supplementary Figure S4. LKB1 specifically regulates CRE-Luc activity. Supplementary Figure S5. shCRTC1 down-regulates NEDD9 mRNA expression. Supplementary Figure S6. Screening for the responsive element of CRTC1/CREB on NEDD9 promoter. Supplementary Figure S7. LKB1 regulates NEDD9 promoter activity through the non-classical CRE site. Supplementary Figure S8. Immunofluorescence assay showed that ectopic Flag-LKB1 expression promoted SIK2 translocation into nucleus in A549 cells. Supplementary Figure S9. Immunofluorescence assay showed that LKB1 knockdown promoted SIK2 translocation into cytoplasm while CRTC1 translocation into nucleus in CRL-5866 cells. Supplementary Figure S10. SIK2 knockdown up-regulates NEDD9 mRNA expression via promoting CRTC1 nuclear translocation. Supplementary Figure S11. Ectopic CRTC1 expression partially reverses the inhibitory function of LKB1 upon cell migration and invasion of human lung cancer cells. Supplementary Figure S12. NEDD9 immunostaining in human lung cancer specimens
Supplementary Methods, Figure 1 from Retinoic Acid/Alpha-Interferon Combination Inhibits Growth and Promotes Apoptosis in Mantle Cell Lymphoma through Akt-Dependent Modulation of Critical Targets
Authors: Dal Col Jessica , Mastorci Katy , Faè Damiana Antonia , Muraro Elena , Martorelli Debora , Inghirami Giorgio , Dolcetti Riccardo
Published: April 2023

PDF file - 123K
Supplementary Figures 1-7 from The Hypoxia-Associated Factor Switches Cells from HIF-1α- to HIF-2α-Dependent Signaling Promoting Stem Cell Characteristics, Aggressive Tumor Growth and Invasion
Authors: Koh Mei Yee , Lemos Robert , Liu Xiuping , Powis Garth
Published: April 2023

Supplementary Figures 1-7 from The Hypoxia-Associated Factor Switches Cells from HIF-1α- to HIF-2α-Dependent Signaling Promoting Stem Cell Characteristics, Aggressive Tumor Growth and Invasion
Supplementary Figure 2 from Estrogen Receptor Alpha Mediates Progestin-Induced Mammary Tumor Growth by Interacting with Progesterone Receptors at the Cyclin D1/MYC Promoters
Authors: Giulianelli Sebastián , Vaqué José P. , Soldati Rocío , Wargon Victoria , Vanzulli Silvia I. , Martins Rubén , Zeitlin Eduardo , Molinolo Alfredo A. , Helguero Luisa A. , Lamb Caroline A. , Gutkind J. Silvio , Lanari Claudia
Published: April 2023

PDF file - 138K, (A) Left. Purified C4-HD cells were cultured in chamber slides. After attachment, the medium was replaced and the cells starved in 1% chFCS for 24 h. Cells were untreated or treated with MPA (10 nM) and/or ICI (1 �M) during 6 h in the presence of BrdU and processed for immunofluorescence and confocal microscopy with specific antibodies: anti-BrdU (green) and cytokeratin (CK, red). Right. Quantification of BrdU+/CK+ cells (mean � SEM) after treatment. (B) Left. 3H-thymidine uptake assays: C4-HD cells were transfected with siRNAs for mouse ER� or a control siRNA, starved, treated for 48 h with MPA and the 3H-thymidine uptake index calculated as described previously. A representative experiment (mean � SEM) of three is shown. Right. Western blots: Protein extracts of C4-HD cells transfected for 48 h with siRNAs for mouse ER� as described previously were used to evaluate the expression of ER� (MC-20) in transfected cells. Erk1/2 was used as a loading control. Cell extracts from C4-HD cells treated with ICI for 24 hs were used as a control. (C) C4-HD cells were starved and then treated with ICI during 6, 12 and 24 h. ER� (MC-20) and PR (C-19) expression was analyzed by Western blot. �-actin (I-19, Santa Cruz) was used as a loading control.
Supplementary Figure 1 from Estrogen Receptor Alpha Mediates Progestin-Induced Mammary Tumor Growth by Interacting with Progesterone Receptors at the Cyclin D1/MYC Promoters
Authors: Giulianelli Sebastián , Vaqué José P. , Soldati Rocío , Wargon Victoria , Vanzulli Silvia I. , Martins Rubén , Zeitlin Eduardo , Molinolo Alfredo A. , Helguero Luisa A. , Lamb Caroline A. , Gutkind J. Silvio , Lanari Claudia
Published: April 2023

PDF file - 251K, (A) Left. C4-HD tumors growing with MPA were untreated or FUL-treated for 48 h and processed for immunohistochemical studies with pER� (Ser167 and Ser118) antibodies. Bar: 60�m. Right. Quantification of positive cells / HPF in untreated or FUL-treated C4-HD tumors. (B) Top. H&E images showing tumor morphology and Ki67 staining after treatment as described in (A). Black arrows show mitotic cells in MPA growing tumors. White arrows show apoptotic cells. Bar: 60�m. Right. Quantification of mitotic or apoptotic cells / HPF in untreated or FUL-treated C4-HD tumors. (C) BCL/XL, BAX and AIF expression after treatment as described in (A). Bar: 60�m.
Supplementary Table 1 from Aptamer Identification of Brain Tumor–Initiating Cells
Authors: Kim Youngmi , Wu Qiulian , Hamerlik Petra , Hitomi Masahiro , Sloan Andrew E. , Barnett Gene H. , Weil Robert J. , Leahy Patrick , Hjelmeland Anita B. , Rich Jeremy N.
Published: April 2023

PDF file - 42K, Aptamer Sequences.
Supplementary Figure Legend from Aptamer Identification of Brain Tumor–Initiating Cells
Authors: Kim Youngmi , Wu Qiulian , Hamerlik Petra , Hitomi Masahiro , Sloan Andrew E. , Barnett Gene H. , Weil Robert J. , Leahy Patrick , Hjelmeland Anita B. , Rich Jeremy N.
Published: April 2023

PDF file - 61K
Supplementary Figure 4 from Endoneurial Macrophages Induce Perineural Invasion of Pancreatic Cancer Cells by Secretion of GDNF and Activation of RET Tyrosine Kinase Receptor
Authors: Cavel Oren , Shomron Olga , Shabtay Ayelet , Vital Joseph , Trejo-Leider Leonor , Weizman Noam , Krelin Yakov , Fong Yuman , Wong Richard J. , Amit Moran , Gil Ziv
Published: April 2023

PDF file - 174K, Expression of the GDNF receptors GFRa1 and RET in specimens excised from patients with pancreatic ductal adenocarcinoma.(a) Low magnification (X20) immunofluorescence staining with anti-RET ab (green, Alexa 485), (b) anti-GFRa1 ab (red, Alexa 565) , and (c) overlay image with DAPI staining (blue). (d) Immunohistochemical staining of the same specimen with anti-CK19 ab (brown staining). (e) High magnification (X40) fluorescent microscope imaging performed with anti-RET (green, Alexa 485), (f) anti-GFRa1 antibodies (red, Alexa 565) and (g) DAPI (blue staining). The overlay image in (h) shows co-expression of the receptors by PDA cells.
Supplementary Figure 4 from Aptamer Identification of Brain Tumor–Initiating Cells
Authors: Kim Youngmi , Wu Qiulian , Hamerlik Petra , Hitomi Masahiro , Sloan Andrew E. , Barnett Gene H. , Weil Robert J. , Leahy Patrick , Hjelmeland Anita B. , Rich Jeremy N.
Published: April 2023

PDF file - 223K, Aptamer high tumor cells display preferential invasion.
Supplementary Figure 3 from Aptamer Identification of Brain Tumor–Initiating Cells
Authors: Kim Youngmi , Wu Qiulian , Hamerlik Petra , Hitomi Masahiro , Sloan Andrew E. , Barnett Gene H. , Weil Robert J. , Leahy Patrick , Hjelmeland Anita B. , Rich Jeremy N.
Published: April 2023

PDF file - 226K, TIC-specific apatmers internalize specifically into TICs.
Supplementary Figure 1 from Endoneurial Macrophages Induce Perineural Invasion of Pancreatic Cancer Cells by Secretion of GDNF and Activation of RET Tyrosine Kinase Receptor
Authors: Cavel Oren , Shomron Olga , Shabtay Ayelet , Vital Joseph , Trejo-Leider Leonor , Weizman Noam , Krelin Yakov , Fong Yuman , Wong Richard J. , Amit Moran , Gil Ziv
Published: April 2023

PDF file - 112K, The ability of EMPhis to invade in a matrigel matrix towards a colony of PDA cancer cells.(a) An illustration showing the calculation of the invasion distance. (b) A photograph of the assay showing that the invasion of EMPhis was more prominent towards the cancer colony than to the other direction (magnification X4). Cancer cells were differentiated from EMPhi by morphologic criteria. (c) Analysis of the results of the invasion assay showing significantly higher migration towards the tumor colony (a- blue bar) compared to the opposite directions (g and beta - red bars, P<.001, n=10).
Supplementary Methods, Figures 1-2, Tables 1-4 from Combinatorial Chemotherapeutic Efficacy in Non-Hodgkin Lymphoma Can Be Predicted by a Signaling Model of CD20 Pharmacodynamics
Authors: Harrold John M. , Straubinger Robert M. , Mager Donald E.
Published: April 2023

PDF file - 1.4MB
Supplementary Table 4 from Inhibition of Histone Demethylase JMJD1A Improves Anti-Angiogenic Therapy and Reduces Tumor-Associated Macrophages
Authors: Osawa Tsuyoshi , Tsuchida Rika , Muramatsu Masashi , Shimamura Teppei , Wang Feng , Suehiro Jun-ichi , Kanki Yasuharu , Wada Youichiro , Yuasa Yasuhito , Aburatani Hiroyuki , Miyano Satoru , Minami Takashi , Kodama Tatsuhiko , Shibuya Masabumi
Published: April 2023

PDF file - 47K, List of 769 genes down-regulated by JMJD1A siRNA in vivo (c.f. Fig. S20).
Supplementary Figure 1 from TWIST1 Is an ERK1/2 Effector That Promotes Invasion and Regulates MMP-1 Expression in Human Melanoma Cells
Authors: Weiss Michele B. , Abel Ethan V. , Mayberry Melanie M. , Basile Kevin J. , Berger Adam C. , Aplin Andrew E.
Published: April 2023

PDF file - 3777K, TWIST1 expression is not regulated by RSK, STAT3, AKT, or by protein stability in mutant B-RAF cell lines
Supplementary Figures 1-6 from Hypoxia-Inducible miR-210 Regulates the Susceptibility of Tumor Cells to Lysis by Cytotoxic T Cells
Authors: Noman Muhammad Zaeem , Buart Stéphanie , Romero Pedro , Ketari Sami , Janji Bassam , Mari Bernard , Mami-Chouaib Fathia , Chouaib Salem
Published: April 2023

PDF file - 779K, This file contains data showing miRNAs upregulated by hypoxia in IGR-Heu and NA-8 cell lines and miR-210 upregulated under hypoxia in several NSCLC and melanoma cell lines. It also contains figure showing the role of hypoxia induced miR-210 in CTL clone-mediated lysis towards NA-8 cells and the effect of miR-210 on hypoxia-induced factors in IGR-Heu cells. Finally it shows the list of 44 validated miR-210 targets from miRanda and the Enrichment of mir-210 in Argonaute complex after IGR-Heu cells were exposed to hypoxia
Supplementary Figure Legends 1-2 from Hypoxia-Inducible miR-210 Regulates the Susceptibility of Tumor Cells to Lysis by Cytotoxic T Cells
Authors: Noman Muhammad Zaeem , Buart Stéphanie , Romero Pedro , Ketari Sami , Janji Bassam , Mari Bernard , Mami-Chouaib Fathia , Chouaib Salem
Published: April 2023

PDF file - 88K
Supplementary Figure 2 from Functional Interaction of Tumor Suppressor DLC1 and Caveolin-1 in Cancer Cells
Authors: Du Xiaoli , Qian Xiaolan , Papageorge Alex , Schetter Aaron J. , Vass William C. , Liu Xi , Braverman Richard , Robles Ana I. , Lowy Douglas R.
Published: April 2023

PDF file - 4MB, siRNA-mediated reduction of CAV1, DLC1, or both CAV1 and DLC1 increases the migration of H1299 cells
Supplementary Table S3 from Enhanced Inhibition of ERK Signaling by a Novel Allosteric MEK Inhibitor, CH5126766, That Suppresses Feedback Reactivation of RAF Activity
Authors: Ishii Nobuya , Harada Naoki , Joseph Eric W. , Ohara Kazuhiro , Miura Takaaki , Sakamoto Hiroshi , Matsuda Yutaka , Tomii Yasushi , Tachibana-Kondo Yukako , Iikura Hitoshi , Aoki Toshihiro , Shimma Nobuo , Arisawa Mikio , Sowa Yoshihiro , Poulikakos Poulikos I. , Rosen Neal , Aoki Yuko , Sakai Toshiyuki
Published: April 2023

Supplementary Table S3 - PDF file 54K, Binding constant between CH5126766 and non-phosphorylated MEK1. Non-phosphorylated His6-MEK1 (WT) was imobilized and affinities between His6-MEK1 and MEK inhibitors were analyzed with SPR
Supplementary Figure 11 from MicroRNAs Regulate Tumor Angiogenesis Modulated by Endothelial Progenitor Cells
Authors: Plummer Prue N. , Freeman Ruth , Taft Ryan J. , Vider Jelena , Sax Michael , Umer Brittany A. , Gao Dingcheng , Johns Christopher , Mattick John S. , Wilton Stephen D. , Ferro Vito , McMillan Nigel A.J. , Swarbrick Alexander , Mittal Vivek , Mellick Albert S.
Published: April 2023

PDF file, 599K, Supplementary Figure S11. Assessment of miRNA Suppression on the Function of Human and Murine Endothelial Cells.
Supplementary Methods from Pivotal Role of the Lipid Raft SK3–Orai1 Complex in Human Cancer Cell Migration and Bone Metastases
Authors: Chantôme Aurélie , Potier-Cartereau Marie , Clarysse Lucie , Fromont Gaëlle , Marionneau-Lambot Séverine , Guéguinou Maxime , Pagès Jean-Christophe , Collin Christine , Oullier Thibauld , Girault Alban , Arbion Flavie , Haelters Jean-Pierre , Jaffrès Paul-Alain , Pinault Michelle , Besson Pierre , Joulin Virginie , Bougnoux Philippe , Vandier Christophe
Published: April 2023

PDF file - 128K
Supplementary Figures 1 - 8 from GDNF–RET Signaling in ER-Positive Breast Cancers Is a Key Determinant of Response and Resistance to Aromatase Inhibitors
Authors: Morandi Andrea , Martin Lesley-Ann , Gao Qiong , Pancholi Sunil , Mackay Alan , Robertson David , Zvelebil Marketa , Dowsett Mitch , Plaza-Menacho Ivan , Isacke Clare M.
Published: April 2023

PDF file - 4112K, Characterization of long-term E2 deprived (LTED) breast cancer cell line (S1); Characterization of the MCF7-2A model (S2); Treatment of MCF7 cells with ICI 182,780 blocks ERdependent GDNF signaling (S3); Generation of the GDNF-RGS (S4); GDNF-RGS positivity correlates with poor outcome in human breast cancer (S5); Kaplan-Meier analyses for breast cancer cases stratified by GDNF-RGS (S6); Correlation of GDNF-RGS with Ki67 staining following anastrozole treatment (S7); ER H-score values in 52 paired primary tumor samples pre-aromatase inhibitor treatment (pre-AI) and recurrent/metastatic tumors following adjuvant AI treatment (post-AI) (S8).
Supplementary Figure 8 from Interleukin-6 Is Required for Pancreatic Cancer Progression by Promoting MAPK Signaling Activation and Oxidative Stress Resistance
Authors: Zhang Yaqing , Yan Wei , Collins Meredith A. , Bednar Filip , Rakshit Sabita , Zetter Bruce R. , Stanger Ben Z. , Chung Ivy , Rhim Andrew D. , di Magliano Marina Pasca
Published: April 2023

PDF file - 223K, Acinar cell proliferation contributes to faster recovery following Kras* inactivation in IL6 deficient mice.
Supplementary Figure 3 from Interleukin-6 Is Required for Pancreatic Cancer Progression by Promoting MAPK Signaling Activation and Oxidative Stress Resistance
Authors: Zhang Yaqing , Yan Wei , Collins Meredith A. , Bednar Filip , Rakshit Sabita , Zetter Bruce R. , Stanger Ben Z. , Chung Ivy , Rhim Andrew D. , di Magliano Marina Pasca
Published: April 2023

PDF file - 253K, IHC staining of IL6, p-Stat3, p-Akt and SMA in iKras* and iKras*;IL6-/- pancreata.
Supplementary Methods from Antitumor Immunotherapeutic and Toxic Properties of an HDL-Conjugated Chimeric IL-15 Fusion Protein
Authors: Ochoa Maria C. , Fioravanti Jessica , Rodriguez Inmaculada , Hervas-Stubbs Sandra , Azpilikueta Arantza , Mazzolini Guillermo , Gúrpide Alfonso , Prieto Jesus , Pardo Julian , Berraondo Pedro , Melero Ignacio
Published: April 2023

PDF file - 144K
Supplementary Figure Legend from Threshold Levels of ABL Tyrosine Kinase Inhibitors Retained in Chronic Myeloid Leukemia Cells Determine Their Commitment to Apoptosis
Authors: O'Hare Thomas , Eide Christopher A. , Agarwal Anupriya , Adrian Lauren T. , Zabriskie Matthew S. , MacKenzie Ryan J. , LaTocha Dorian H. , Johnson Kara J. , You Huihong , Luo Jenny , Riddle Steven M. , Marks Bryan D. , Vogel Kurt W. , Koop Dennis R. , Apgar John , Tyner Jeffrey W. , Deininger Michael W. , Druker Brian J.
Published: April 2023

PDF file - 45K
Supplementary Figure Legend, Figures 1 - 8, Table 1 from GPR116, an Adhesion G-Protein–Coupled Receptor, Promotes Breast Cancer Metastasis via the Gαq-p63RhoGEF-Rho GTPase Pathway
Authors: Tang Xiaolong , Jin Rongrong , Qu Guojun , Wang Xiu , Li Zhenxi , Yuan Zengjin , Zhao Chen , Siwko Stefan , Shi Tieliu , Wang Ping , Xiao Jianru , Liu Mingyao , Luo Jian
Published: April 2023

PDF file - 367K, Fig S1. Screening adhesion GPCR expression in breast cancer cells. Fig S2. The GPR116 expression in knockdown or rescued breast cancer cells. Fig S3. Knockdown of GPR116 had little effect on breast cancer cell growth and apoptosis. Fig S4. The expression of GPR116 in breast cancer cell lines was quantified by Real-time PCR. Fig S5. Overexpression of GPR116 increased the activitiy of RhoA and Rac1 but not Cdc42 in 293T cells as measured by GTPase pull-down assays. Fig S6. Regulation of actin stress fibers and lamellipodia by GPR116 is RhoA and Rac1 dependent. Fig S7. The effect of RGS domain of p115RGS and Gq CT-His on GPR116 induced activity of RhoA and Rac1. Fig S8. Two additional independent experiments of Fig. 4F and Fig. 4G. Table S1. Oligonucleotide sequences of PCR primers.
Supplementary Figures from Tumor Promotion by Intratumoral Plasmacytoid Dendritic Cells Is Reversed by TLR7 Ligand Treatment
Authors: Le Mercier Isabelle , Poujol Dominique , Sanlaville Amélien , Sisirak Vanja , Gobert Michael , Durand Isabelle , Dubois Bertrand , Treilleux Isabelle , Marvel Jacqueline , Vlach Jaromir , Blay Jean-Yves , Bendriss-Vermare Nathalie , Caux Christophe , Puisieux Isabelle , Goutagny Nadège
Published: April 2023

Supplementary Figures - PDF file 322K, S1. Spontaneous MMTVneu display high Her2/neu expression. S2. FoxP3 expression among CD4+ CD25+ T cells correlates with CD45RB negativity. S3. NEU15WT TApDC display unaltered uptake ability. S4. NEU15WT TApDC display unaltered TLR7 and TLR9 expression. S5. Fold changes in gene expression upon intratumoral TLR7L injection. S6. Intratumoral TLR7L or CpG injection induced distinct immune cell recruitment. S7. List of flurochrome-conjugated antibodies used for multi-parametric flow cytometry analysis
Supplementary Figures 1 - 9, Tables 1 - 3 from Combination of Protein Coding and Noncoding Gene Expression as a Robust Prognostic Classifier in Stage I Lung Adenocarcinoma
Authors: Akagi Ichiro , Okayama Hirokazu , Schetter Aaron J. , Robles Ana I. , Kohno Takashi , Bowman Elise D. , Kazandjian Dickran , Welsh Judith A. , Oue Naohide , Saito Motonobu , Miyashita Masao , Uchida Eiji , Takizawa Toshihiro , Takenoshita Seiichi , Skaug Vidar , Mollerup Steen , Haugen Aage , Yokota Jun , Harris Curtis C.
Published: April 2023

PDF file - 836K, Supplemental Figure 1: Overview of the study design for the identification of candidate coding genes, development and validation of the four coding gene classifier using five independent datasets. Supplemental Figure 2: Technical validation of the microarray experiments showing Pearson�s correlation between microarray expression values and qRT-PCR expression values for each gene across all tumors that were examined.Supplemental Figure 3: Kaplan-Meier survival curves according to tertiles of the four coding gene classifier in AJCC 6th edition stage I-II lung adenocarcinoma from five independent cohorts, including the Japan (n=199, relapse-free survival), US/Norway (n=92, cancer specific mortality), Directors� (n=378, overall survival), Bhattacharjee (n=100, overall survival) and Tomida (n=92, overall survival) cohorts. P-values were estimated by log-rank test for trend. Supplemental Figure 4: For survival analysis, miR-21 expression values as measured by nCounter miRNA assays were normalized to the average of the 5 most highly expressed microRNAs in tumor tissue, excluding miR-21 itself. Supplemental Figure 5: In the Japan cohort, the four coding gene classifier and the non-coding miR-21 classifier are each significantly associated with relapse-free survival.Supplemental Figure 6: In the US/Norway cohort, the four coding gene classifier and the non-coding miR-21 classifier are each significantly associated with relapse-free survival. Supplemental Figure 7: Estimation of miR-21 copies per cell in lung adenocarcinoma tissue by PCR-based absolute quantification. Supplemental Figure 8: Total RNA content per lung tumor cell was estimated at approximately 20pg per cell based on a series of total RNA extraction from serially diluted cultured lung adenocarcinoma cell lines A549 and NCI-H23. Supplemental Figure 9: Prognostic significance of BRCA1 expression in multiple cancer types. Supplemental Table 1. Characteristics of study populations of patients from public database. Supplemental Table 2. Univariate Cox regression analysis in the Japan cohort using microarray data (AJCC TNM 6th, Stage I, n=148). Supplemental Table 3. Univariate Cox Regression analysis of the expression of six genes.
Supplementary Table 8 from MYC Phosphorylation at Novel Regulatory Regions Suppresses Transforming Activity
Authors: Wasylishen Amanda R. , Chan-Seng-Yue Michelle , Bros Christina , Dingar Dharmendra , Tu William B. , Kalkat Manpreet , Chan Pak-Kei , Mullen Peter J. , Huang Ling , Meyer Natalie , Raught Brian , Boutros Paul C. , Penn Linda Z.
Published: April 2023

XLS file, 3148K, Compiled expression array and ChIP-on-chip data.
Supplementary Table 7 from MYC Phosphorylation at Novel Regulatory Regions Suppresses Transforming Activity
Authors: Wasylishen Amanda R. , Chan-Seng-Yue Michelle , Bros Christina , Dingar Dharmendra , Tu William B. , Kalkat Manpreet , Chan Pak-Kei , Mullen Peter J. , Huang Ling , Meyer Natalie , Raught Brian , Boutros Paul C. , Penn Linda Z.
Published: April 2023

XLSX file, 16K, Gene expression changes common to all gain-of-function MYC phosphorylation mutants (158 genes).
Supplementary Table 2 from Chemopreventive Activity of Plant Flavonoid Isorhamnetin in Colorectal Cancer Is Mediated by Oncogenic Src and β-Catenin
Authors: Saud Shakir M. , Young Matthew R. , Jones-Hall Yava L. , Ileva Lilia , Evbuomwan Moses O. , Wise Jennifer , Colburn Nancy H. , Kim Young S. , Bobe Gerd
Published: April 2023

PDF file, 72K, Histological assessment of colonic inflammation (Colitis Score).
Supplementary Table 6 from MYC Phosphorylation at Novel Regulatory Regions Suppresses Transforming Activity
Authors: Wasylishen Amanda R. , Chan-Seng-Yue Michelle , Bros Christina , Dingar Dharmendra , Tu William B. , Kalkat Manpreet , Chan Pak-Kei , Mullen Peter J. , Huang Ling , Meyer Natalie , Raught Brian , Boutros Paul C. , Penn Linda Z.
Published: April 2023

XLS file, 403K, Expression comparison between wild-type MYC and MYC phosphorylation mutants (from Venn diagram)
Supplementary Table 1 from MYC Phosphorylation at Novel Regulatory Regions Suppresses Transforming Activity
Authors: Wasylishen Amanda R. , Chan-Seng-Yue Michelle , Bros Christina , Dingar Dharmendra , Tu William B. , Kalkat Manpreet , Chan Pak-Kei , Mullen Peter J. , Huang Ling , Meyer Natalie , Raught Brian , Boutros Paul C. , Penn Linda Z.
Published: April 2023

XLS file, 14K, Phosphopeptide analysis for ectopic MYC in 293Tv cells.
Supplementary Figures from MYC Phosphorylation at Novel Regulatory Regions Suppresses Transforming Activity
Authors: Wasylishen Amanda R. , Chan-Seng-Yue Michelle , Bros Christina , Dingar Dharmendra , Tu William B. , Kalkat Manpreet , Chan Pak-Kei , Mullen Peter J. , Huang Ling , Meyer Natalie , Raught Brian , Boutros Paul C. , Penn Linda Z.
Published: April 2023

PDF file, 498K, Supplementary Figures S1-6 Supplementary Figure S1: Phosphorylation mutants increase Myc-induced transformation in MCF10A cells. Supplementary Figure S2: Phosphorylation mutants increase Myc-induced transformation in SH-EP cells. Supplementary Figure S3: Phosphorylation mutants do not effect MYC protein stability. Supplementary Figure S4: Serum starvation of MCF10A-GFP and MCF10A-MYC cells. Supplementary Figure S5: MYC protein expression through morphogenesis of MCF10A cells in 3D culture. Supplementary Figure S6: Characterization of day 4 acini for mRNA expression array analysis.
Supplementary Figure S1 from Peroxiredoxin-2 Represses Melanoma Metastasis by Increasing E-Cadherin/β-Catenin Complexes in Adherens Junctions
Authors: Lee Doo Jae , Kang Dong Hoon , Choi Mina , Choi Yang Ji , Lee Joo Young , Park Joo Hyun , Park Yoon Jung , Lee Kyung Wha , Kang Sang Won
Published: April 2023

Supplementary Figure S1�- PDF file 821K, Expression status of Prx1 or Prx2 in melanoma cells
Supplementary Figure Legend and Movie Legend from CIP4 Controls CCL19-Driven Cell Steering and Chemotaxis in Chronic Lymphocytic Leukemia
Authors: Malet-Engra Gema , Viaud Julien , Ysebaert Loïc , Farcé Manon , Lafouresse Fanny , Laurent Guy , Gaits-Iacovoni Frédérique , Scita Giorgio , Dupré Loïc
Published: April 2023

PDF file - 74K
Supplementary Figure 3 from A Small-Molecule Blocking Ribonucleotide Reductase Holoenzyme Formation Inhibits Cancer Cell Growth and Overcomes Drug Resistance
Authors: Zhou Bingsen , Su Leila , Hu Shuya , Hu Weidong , Yip M.L. Richard , Wu Jun , Gaur Shikha , Smith D. Lynne , Yuan Yate-Ching , Synold Timothy W. , Horne David , Yen Yun
Published: April 2023

PDF file - 164K, Supplemental figure 3: Proposed COH29 binding mode and effect of RRM2 point mutations.
Supplementary Table from C1GALT1 Enhances Proliferation of Hepatocellular Carcinoma Cells via Modulating MET Glycosylation and Dimerization
Authors: Wu Yao-Ming , Liu Chiung-Hui , Huang Miao-Juei , Lai Hong-Shiee , Lee Po-Huang , Hu Rey-Heng , Huang Min-Chuan
Published: April 2023

PDF file, 130K, Correlation of C1GALT1 expression with clinicopathologic features in HCC tissue microarray.
Supplementary Figure 2 from Disruption of Wild-Type IDH1 Suppresses D-2-Hydroxyglutarate Production in IDH1-Mutated Gliomas
Authors: Jin Genglin , Reitman Zachary J. , Duncan Christopher G. , Spasojevic Ivan , Gooden David M. , Rasheed B. Ahmed , Yang Rui , Lopez Giselle Y. , He Yiping , McLendon Roger E. , Bigner Darell D. , Yan Hai
Published: April 2023

PDF file-28KB, Comparison of growth and apoptosis for parental IMA cells and IMA cells with the IDH1-WT allele knocked out (KO)
Supplementary Figure S2 from Extracellular DNA in Pancreatic Cancer Promotes Cell Invasion and Metastasis
Authors: Wen Fushi , Shen Alex , Choi Andrew , Gerner Eugene W. , Shi Jiaqi
Published: April 2023

PDF file - 610K, Inactivated DNase I has no effect on exDNA
Supplementary Figure 1 from Disruption of Wild-Type IDH1 Suppresses D-2-Hydroxyglutarate Production in IDH1-Mutated Gliomas
Authors: Jin Genglin , Reitman Zachary J. , Duncan Christopher G. , Spasojevic Ivan , Gooden David M. , Rasheed B. Ahmed , Yang Rui , Lopez Giselle Y. , He Yiping , McLendon Roger E. , Bigner Darell D. , Yan Hai
Published: April 2023

PDF file-31KB, Synthesis of octyl-�-ketoglutarate
Supplementary Table 1 from DOG1 Regulates Growth and IGFBP5 in Gastrointestinal Stromal Tumors
Authors: Simon Susanne , Grabellus Florian , Ferrera Loretta , Galietta Luis , Schwindenhammer Benjamin , Mühlenberg Thomas , Taeger Georg , Eilers Grant , Treckmann Juergen , Breitenbuecher Frank , Schuler Martin , Taguchi Takahiro , Fletcher Jonathan A. , Bauer Sebastian
Published: April 2023

PDF - 41K, List of genes with strongest differential expression in GISTT1 with scrambled control versus DOG1-knockdown in xenografts.
Supplementary Methods from An Antibody That Locks HER3 in the Inactive Conformation Inhibits Tumor Growth Driven by HER2 or Neuregulin
Authors: Garner Andrew P. , Bialucha Carl U. , Sprague Elizabeth R. , Garrett Joan T. , Sheng Qing , Li Sharon , Sineshchekova Olga , Saxena Parmita , Sutton Cammie R. , Chen Dongshu , Chen Yan , Wang Huiqin , Liang Jinsheng , Das Rita , Mosher Rebecca , Gu Jian , Huang Alan , Haubst Nicole , Zehetmeier Carolin , Haberl Manuela , Elis Winfried , Kunz Christian , Heidt Analeah B. , Herlihy Kara , Murtie Joshua , Schuller Alwin , Arteaga Carlos L. , Sellers William R. , Ettenberg Seth A.
Published: April 2023

PDF file - 204K
Supplementary Figure 3 from An Antibody That Locks HER3 in the Inactive Conformation Inhibits Tumor Growth Driven by HER2 or Neuregulin
Authors: Garner Andrew P. , Bialucha Carl U. , Sprague Elizabeth R. , Garrett Joan T. , Sheng Qing , Li Sharon , Sineshchekova Olga , Saxena Parmita , Sutton Cammie R. , Chen Dongshu , Chen Yan , Wang Huiqin , Liang Jinsheng , Das Rita , Mosher Rebecca , Gu Jian , Huang Alan , Haubst Nicole , Zehetmeier Carolin , Haberl Manuela , Elis Winfried , Kunz Christian , Heidt Analeah B. , Herlihy Kara , Murtie Joshua , Schuller Alwin , Arteaga Carlos L. , Sellers William R. , Ettenberg Seth A.
Published: April 2023

PDF file - 239K, Figure S3. LJM716 is specific for HER3 and binds a conformational epitope that includes key residues in D2.
Supplementary Figure 1 from DNA Methylation-Mediated Repression of miR-886-3p Predicts Poor Outcome of Human Small Cell Lung Cancer
Authors: Cao Jianzhong , Song Yongmei , Bi Nan , Shen Jie , Liu Wenyang , Fan Jing , Sun Guogui , Tong Tong , He Jie , Shi Yuankai , Zhang Xun , Lu Ning , He Yinghua , Zhang Hongyu , Ma Kelong , Luo Xiaoying , Lv Lei , Deng Hui , Cheng Jing , Zhu Jingde , Wang Luhua , Zhan Qimin
Published: April 2023

PDF file - 129K, Kaplan-Meier analyses for progression free survival (PFS) and distant metastasis free survival (DMFS) between the low and high miR-886-3p expressing groups.
Supplementary Table 3 from Intestinal Bacteria Modify Lymphoma Incidence and Latency by Affecting Systemic Inflammatory State, Oxidative Stress, and Leukocyte Genotoxicity
Authors: Yamamoto Mitsuko L. , Maier Irene , Dang Angeline Tilly , Berry David , Liu Jared , Ruegger Paul M. , Yang Jiue-in , Soto Phillip A. , Presley Laura L. , Reliene Ramune , Westbrook Aya M. , Wei Bo , Loy Alexander , Chang Christopher , Braun Jonathan , Borneman James , Schiestl Robert H.
Published: April 2023

PDF file - 551K, Relative Abundance of OTU of CM and RM Mice by Genotype and Intestinal Region.
Supplementary Figure 4 from Carboxyl-Terminal Modulator Protein Positively Regulates Akt Phosphorylation and Acts as an Oncogenic Driver in Breast Cancer
Authors: Liu Yu-Peng , Liao Wen-Chi , Ger Luo-Ping , Chen Jiun-Chin , Hsu Tai-I , Lee Yu-Cheng , Chang Hong-Tai , Chen Yu-Chia , Jan Yi-Hua , Lee Kuen-Haur , Zeng Yu-Hao , Hsiao Michael , Lu Pei-Jung
Published: April 2023

PDF file, 114K, CTMP mRNA expression data adapted from GEO public available microarray database, GSE3744.
Supplementary Table 1 from Combined Targeting of PDK1 and EGFR Triggers Regression of Glioblastoma by Reversing the Warburg Effect
Authors: Velpula Kiran Kumar , Bhasin Arnima , Asuthkar Swapna , Tsung Andrew J.
Published: April 2023

PDF file - 30K, Supplementary Table 1: Primers used for RT-PCR are listed below.
Supplementary Figure 1 from Characterization of Rearrangements Involving the ALK Gene Reveals a Novel Truncated Form Associated with Tumor Aggressiveness in Neuroblastoma
Authors: Cazes Alex , Louis-Brennetot Caroline , Mazot Pierre , Dingli Florent , Lombard Bérangère , Boeva Valentina , Daveau Romain , Cappo Julie , Combaret Valérie , Schleiermacher Gudrun , Jouannet Stéphanie , Ferrand Sandrine , Pierron Gaëlle , Barillot Emmanuel , Loew Damarys , Vigny Marc , Delattre Olivier , Janoueix-Lerosey Isabelle
Published: April 2023

PDF file - 110K, FISH analysis on the CLB-Re cell line using the LSI ALK dual color, Break Apart Rearrangement probe (Vysis)
Supplementary Figure 3 from Combined Targeting of PDK1 and EGFR Triggers Regression of Glioblastoma by Reversing the Warburg Effect
Authors: Velpula Kiran Kumar , Bhasin Arnima , Asuthkar Swapna , Tsung Andrew J.
Published: April 2023

PDF file - 179K, Supplementary Figure 3. hUCBSC treatment suppress pEGFR-PDK1 interaction in vivo.