bluuebunny/crossref_metadata_2025 huggingface dataset:
Recent Research Progress on All-Solid-State Mg Batteries
Authors: Pandeeswari Jayaraman , Jenisha Gunamony , Walle Kumlachew Zelalem , Kotobuki Masashi
Published: November 2023

Current Li battery technology employs graphite anode and flammable organic liquid electrolytes. Thus, the current Li battery is always facing the problems of low energy density and safety. Additionally, the sustainable supply of Li due to the scarce abundance of Li sources is another problem. An all-solid-state Mg battery is expected to solve the problems owing to non-flammable solid-state electrolytes, high capacity/safety of divalent Mg metal anode and high abundance of Mg sources; therefore, solid-state electrolytes and all-solid-state Mg batteries have been researched intensively last two decades. However, the realization of all-solid-state Mg batteries is still far off. In this article, we review the recent research progress on all-solid-state Mg batteries so that researchers can pursue recent research trends of an all-solid-state Mg battery. At first, the solid-state electrolyte research is described briefly in the categories of inorganic, organic and inorganic/organic composite electrolytes. After that, the recent research progress of all-solid-state Mg batteries is summarized and analyzed. To help readers, we tabulate electrode materials, experimental conditions and performances of an all-solid-state Mg battery so that the readers can find the necessary information at a glance. In the last, challenges to realize the all-solid-state Mg batteries are visited.
Second-Life Batteries: A Review on Power Grid Applications, Degradation Mechanisms, and Power Electronics Interface Architectures
Authors: Hassan Ali , Khan Shahid , Li Rongheng , Su Wencong , Zhou Xuan , Wang Mengqi , Wang Bin
Published: November 2023

The adoption of electric vehicles (EVs) is increasing due to governmental policies focused on curbing climate change. EV batteries are retired when they are no longer suitable for energy-intensive EV operations. A large number of EV batteries are expected to be retired in the next 5–10 years. These retired batteries have 70–80% average capacity left. Second-life use of these battery packs has the potential to address the increasing energy storage system (ESS) demand for the grid and also to create a circular economy for EV batteries. The needs of modern grids for frequency regulation, power smoothing, and peak shaving can be met using retired batteries. Moreover, these batteries can also be employed for revenue generation for energy arbitrage (EA). While there are articles reviewing the general applications of retired batteries, this paper presents a comprehensive review of the research work on applications of the second-life batteries (SLBs) specific to the power grid and SLB degradation. The power electronics interface and battery management systems for the SLB are also thoroughly reviewed.
Engagement of Mesenchymal Stromal Cells in the Remodeling of the Bone Marrow Microenvironment in Hematological Cancers
Authors: Giallongo Sebastiano , Duminuco Andrea , Dulcamare Ilaria , Zuppelli Tatiana , La Spina Enrico , Scandura Grazia , Santisi Annalisa , Romano Alessandra , Di Raimondo Francesco , Tibullo Daniele , Palumbo Giuseppe A. , Giallongo Cesarina
Published: November 2023

Mesenchymal stromal cells (MSCs) are a subset of heterogeneous, non-hematopoietic fibroblast-like cells which play important roles in tissue repair, inflammation, and immune modulation. MSCs residing in the bone marrow microenvironment (BMME) functionally interact with hematopoietic stem progenitor cells regulating hematopoiesis. However, MSCs have also emerged in recent years as key regulators of the tumor microenvironment. Indeed, they are now considered active players in the pathophysiology of hematologic malignancies rather than passive bystanders in the hematopoietic microenvironment. Once a malignant event occurs, the BMME acquires cellular, molecular, and epigenetic abnormalities affecting tumor growth and progression. In this context, MSC behavior is affected by signals coming from cancer cells. Furthermore, it has been shown that stromal cells themselves play a major role in several hematological malignancies’ pathogenesis. This bidirectional crosstalk creates a functional tumor niche unit wherein tumor cells acquire a selective advantage over their normal counterparts and are protected from drug treatment. It is therefore of critical importance to unveil the underlying mechanisms which activate a protumor phenotype of MSCs for defining the unmasked vulnerabilities of hematological cancer cells which could be pharmacologically exploited to disrupt tumor/MSC coupling. The present review focuses on the current knowledge about MSC dysfunction mechanisms in the BMME of hematological cancers, sustaining tumor growth, immune escape, and cancer progression.
Protein Association in Solution: Statistical Mechanical Modeling
Authors: Vlachy Vojko , Kalyuzhnyi Yurij V. , Hribar-Lee Barbara , Dill Ken A.
Published: November 2023

Protein molecules associate in solution, often in clusters beyond pairwise, leading to liquid phase separations and high viscosities. It is often impractical to study these multi-protein systems by atomistic computer simulations, particularly in multi-component solvents. Instead, their forces and states can be studied by liquid state statistical mechanics. However, past such approaches, such as the Derjaguin-Landau-Verwey-Overbeek (DLVO) theory, were limited to modeling proteins as spheres, and contained no microscopic structure–property relations. Recently, this limitation has been partly overcome by bringing the powerful Wertheim theory of associating molecules to bear on protein association equilibria. Here, we review these developments.
Effect of Vancomycin, Gentamicin and Clindamycin on Cartilage Cells In Vitro
Authors: Mayr Hermann O. , Regenbrecht Nina , Mayr Moritz Florian , Riedel Bianca , Hart Melanie L. , Schmal Hagen , Seidenstuecker Michael
Published: November 2023

Background: The treatment of grafts with vancomycin for ligament reconstruction in knee surgery is the current standard. However, high antibiotic concentrations have chondrotoxic effects. Purpose: To test the chondrotoxicity of clindamycin, gentamicin and vancomycin in comparable concentrations. In vitro and in vivo effective concentrations hugely vary from drug to drug. To allow for comparisons between these three commonly used antibiotics, the concentration ranges frequently used in orthopedic surgical settings were tested. Study Design: Controlled laboratory study. Methods: Human cartilage from 10 specimens was used to isolate chondrocytes. The chondrocytes were treated with clindamycin (1 mg/mL and 0.5 mg/mL), gentamicin (10 mg/mL and 5 mg/mL) or vancomycin (10 mg/mL and 5 mg/mL), at concentrations used for preoperative infection prophylaxis in ligament surgery. Observations were taken over a period of 7 days. A control of untreated chondrocytes was included. To test the chondrotoxicity, a lactate dehydrogenase (LDH) test and a water-soluble tetrazolium salt (WST-1) assay were performed on days 1, 3 and 7. In addition, microscopic examinations were performed after fluorescence staining of the cells at the same time intervals. Results: All samples showed a reasonable vitality of the cartilage cells after 72 h. However, clindamycin and gentamicin both showed higher chondrotoxicity in all investigations compared to vancomycin. After a period of 7 days, only chondrocytes treated with vancomycin showed reasonable vitality. Conclusions: The preoperative treatment of ligament grafts with vancomycin is the most reasonable method for infection prophylaxis, in accordance with the current study results regarding chondrotoxicity; however, clindamycin and gentamicin cover a wider anti-bacterial spectrum. Clinical Relevance: The prophylactic antibiotic treatment of ligament grafts at concentrations of 5 mg/mL or 10 mg/mL vancomycin is justifiable and reasonable. In specific cases, even the use of gentamicin and clindamycin is appropriate.
Elevated Anti-Müllerian Hormone as a Prognostic Factor for Poor Outcomes of In Vitro Fertilization in Women with Polycystic Ovary Syndrome
Authors: Vale-Fernandes Emídio , Barreiro Márcia , Leal Carla , Macedo Rosa Zulmira , Tomé António , Monteiro Mariana P.
Published: November 2023

Women with polycystic ovary syndrome (PCOS) tend to have elevated anti-Müllerian hormone (AMH) levels, which appear to correlate with disease severity and pregnancy outcomes. This was a retrospective observational study designed to assess the relationship between circulating AMH levels and in vitro fertilization (IVF) outcomes. The study involved 150 women with PCOS who underwent IVF treatments. The women’s IVF cycles were allocated into three subgroups according to AMH levels: ‘low’ (AMH < 3.7 ng/mL; n = 49), ‘middle’ (AMH 3.7–7.4 ng/mL; n = 94), and ‘high’ (AMH > 7.4 ng/mL; n = 56). All pregnancy-related outcomes (positive beta human chorionic gonadotropin (βHCG), clinical pregnancy rate, live birth rate, and cumulative live birth rate) were greater in women’s IVF cycles with ‘low’ AMH when compared to those with ‘middle’ or ‘high’ AMH (p < 0.05). AMH levels below 3.7 ng/mL were found to be associated with lower oocyte immaturity rate and better pregnancy outcomes, although baseline AMH was not shown to have any significant predictive power for live birth and cumulative live birth in the multivariable logistic regression analysis after adjusting for possible confounders nor in the ROC analyses. In summary, the current study lays the groundwork to validate high AMH levels as a poor prognostic factor for pregnancy outcomes after IVF in women with PCOS.
The Serum ACE2, CTSL, AngII, and TNFα Levels after COVID-19 and mRNA Vaccines: The Molecular Basis
Authors: Pencheva Mina , Bozhkova Martina , Kalchev Yordan , Petrov Steliyan , Baldzhieva Alexandra , Kalfova Teodora , Dichev Valentin , Keskinova Donka , Genova Silvia , Atanasova Mariya , Murdzheva Mariana
Published: November 2023

Background: The SARS-CoV-2 virus as well as the COVID-19 mRNA vaccines cause an increased production of proinflammatory cytokines. Aim: We investigated the relationship between ACE2, CTSL, AngII, TNFα and the serum levels of IL-6, IL-10, IL-33, IL-28A, CD40L, total IgM, IgG, IgA and absolute count of T- and B-lymphocytes in COVID-19 patients, vaccinees and healthy individuals. Methods: We measured the serum levels ACE2, AngII, CTSL, TNFα and humoral biomarkers (CD40L, IL-28A, IL-10, IL-33) by the ELISA method. Immunophenotyping of lymphocyte subpopulations was performed by flow cytometry. Total serum immunoglobulins were analyzed by the turbidimetry method. Results: The results established an increase in the total serum levels for ACE2, CTSL, AngII and TNFα by severely ill patients and vaccinated persons. The correlation analysis described a positive relationship between ACE2 and proinflammatory cytokines IL-33 (r = 0.539) and CD40L (r = 0.520), a positive relationship between AngII and CD40L (r = 0.504), as well as between AngII and IL-33 (r = 0.416), and a positive relationship between CTSL, total IgA (r = 0.437) and IL-28A (r = 0.592). Correlation analysis confirmed only two of the positive relationships between TNFα and IL-28A (r = 0.491) and CD40L (r = 0.458). Conclusions: In summary, the findings presented in this study unveil a complex web of interactions within the immune system in response to SARS-CoV-2 infection and vaccination.
Low-Cost Angle Sensor for Robotics Applications Using Plastic Optical Fiber Based on Optical Loss Mechanism
Authors: Lee Hyun-Woo , Kim Dae-Hyun , Shin Sangwoo
Published: November 2023

Robotic systems and the human body consist of numerous joint structures, all of which require precise angle adjustments. At present, encoder, strain gauge, and electrical resistance-based sensors are commonly used for angle measurement. However, these sensors have limitations when used in underwater or in environments with strong electromagnetic waves. Therefore, we have developed an angle sensor based on step-index profile plastic optical fiber (SI-POF), which is cost-effective and highly durable, in this study in order to overcome the limitations of existing angle measurement sensors. To this end, the amount of light loss according to the gab and angle changes that occur when the POF angle sensor is applied to the robot arm was experimentally measured, and based on the results, a simulation of the amount of light loss when the two losses occurred at the same time was conducted. In addition, the performance of the POF angle sensor was evaluated by measuring sensitivity and resolution, and comparative verification with a commonly used encoder was conducted to verify the reliability of sensors in extreme environments, such as those with electromagnetic fields and those that are underwater. Through this, the reliability and practicality of the POF angle sensor were confirmed. The results obtained in this study suggest that POF-based angle sensors can contribute to the development of the biomimetic robot industry as well as ordinary robots, especially in environments where existing sensors are difficult to apply, such as areas with underwater or electromagnetic interference (EMI).
Vein–Membrane Interaction in Cambering of Flapping Insect Wings
Authors: Ishihara Daisuke , Onishi Minato , Sugikawa Kaede
Published: November 2023

It is still unclear how elastic deformation of flapping insect wings caused by the aerodynamic pressure results in their significant cambering. In this study, we present that a vein–membrane interaction (VMI) can clarify this mechanical process. In order to investigate the VMI, we propose a numerical method that consists of (a) a shape simplification model wing that consists of a few beams and a rectangular shell structure as the structural essence of flapping insect wings for the VMI, and (b) a monolithic solution procedure for strongly coupled beam and shell structures with large deformation and large rotation to analyze the shape simplification model wing. We incorporate data from actual insects into the proposed numerical method for the VMI. In the numerical analysis, we demonstrate that the model wing can generate a camber equivalent to that of the actual insects. Hence, the VMI will be a mechanical basis of the cambering of flapping insect wings. Furthermore, we present the mechanical roles of the veins in cambering. The intermediate veins increase the out-of-plane deflection of the wing membrane due to the aerodynamic pressure in the central area of the wing, while they decrease it in the vicinity of the trailing edge. As a result, these veins create the significant camber. The torsional flexibility of the leading-edge veins increases the magnitude of cambering.
Microgravity as an Anti-Metastatic Agent in an In Vitro Glioma Model
Authors: Sabbatini Maurizio , Bonetto Valentina , Magnelli Valeria , Lorusso Candida , Dondero Francesco , Masini Maria Angela
Published: November 2023

Gravity is a primary physical force that has a profound influence on the stability of the cell cytoskeleton. In our research, we investigated the influence of microgravity on altering the cytoskeletal pathways of glioblastoma cells. The highly infiltrative behavior of glioblastoma is supported by cytoskeletal dynamics and surface proteins that allow glioblastoma cells to avoid stable connections with the tissue environment and other cells. Glioblastoma cell line C6 was exposed to a microgravity environment for 24, 48, and 72 h by 3D-RPM, a laboratory instrument recognized to reproduce the effect of microgravity in cell cultures. The immunofluorescence for GFAP, vinculin, and Connexin-43 was investigated as signals related to cytoskeleton dynamics. The polymerization of GFAP and the expression of focal contact structured by vinculin were found to be altered, especially after 48 and 72 h of microgravity. Connexin-43, involved in several intracellular pathways that critically promote cell motility and invasion of glioma cells, was found to be largely reduced following microgravity exposure. In conclusion, microgravity, by reducing the expression of Connexin-43, alters the architecture of specific cytoskeletal elements such as GFAP and increases the focal contact, which can induce a reduction in glioma cell mobility, thereby inhibiting their aggressive metastatic behavior.
Reliability, Validity, and Identification Ability of a Commercialized Waist-Attached Inertial Measurement Unit (IMU) Sensor-Based System in Fall Risk Assessment of Older People
Authors: Li Ke-Jing , Wong Nicky Lok-Yi , Law Man-Ching , Lam Freddy Man-Hin , Wong Hoi-Ching , Chan Tsz-On , Wong Kit-Naam , Zheng Yong-Ping , Huang Qi-Yao , Wong Arnold Yu-Lok , Kwok Timothy Chi-Yui , Ma Christina Zong-Hao
Published: November 2023

Falls are a prevalent cause of injury among older people. While some wearable inertial measurement unit (IMU) sensor-based systems have been widely investigated for fall risk assessment, their reliability, validity, and identification ability in community-dwelling older people remain unclear. Therefore, this study evaluated the performance of a commercially available IMU sensor-based fall risk assessment system among 20 community-dwelling older recurrent fallers (with a history of ≥2 falls in the past 12 months) and 20 community-dwelling older non-fallers (no history of falls in the past 12 months), together with applying the clinical scale of the Mini-Balance Evaluation Systems Test (Mini-BESTest). The results show that the IMU sensor-based system exhibited a significant moderate to excellent test–retest reliability (ICC = 0.838, p < 0.001), an acceptable level of internal consistency reliability (Spearman’s rho = 0.471, p = 0.002), an acceptable convergent validity (Cronbach’s α = 0.712), and an area under the curve (AUC) value of 0.590 for the IMU sensor-based receiver-operating characteristic (ROC) curve. The findings suggest that while the evaluated IMU sensor-based system exhibited good reliability and acceptable validity, it might not be able to fully identify the recurrent fallers and non-fallers in a community-dwelling older population. Further system optimization is still needed.
Physiological Correlates of Hypnotizability: Hypnotic Behaviour and Prognostic Role in Medicine
Authors: Malloggi Eleonora , Santarcangelo Enrica L.
Published: November 2023

Studies in the field of experimental hypnosis highlighted the role of hypnotizability in the physiological variability of the general population. It is associated, in fact, with a few differences which are observable in the ordinary state of consciousness and in the absence of suggestions. The aim of the present scoping review is summarizing them and indicate their relevance to the neural mechanisms of hypnosis and to the prognosis and treatment of a few medical conditions. Individuals with high, medium and low hypnotizability scores display different cerebral functional differences—i.e., functional equivalence between imagery and perception/action, excitability of the motor cortex, interoceptive accuracy—possibly related to brain structural and functional characteristics, and different control of blood supply at peripheral and cerebral level, likely due to different availability of endothelial nitric oxide. These differences are reviewed to support the idea of their participation in hypnotic behaviour and to indicate their prognostic and therapeutic usefulness in a few medical conditions.
Pro-Environmental Behavior and Climate Change Anxiety, Perception, Hope, and Despair According to Political Orientation
Authors: Leite Ângela , Lopes Diana , Pereira Linda
Published: November 2023

The main objective of this paper is to assess pro-environmental behavior, climate change anxiety, perception, hope, and despair in different political orientations. Our specific aims included to assess the validity of all the instruments used; to assess whether the factor structure of the scales were valid across political orientations; to evaluate their reliability; to assess differences concerning age, gender, and political orientation; to learn the variables that explain pro-environmental behavior; and to evaluate the moderating role of climate change perception, despair, and hope in the relationship between climate change anxiety and pro-environmental behavior. Confirmatory factor analyses (CFAs), multi-group CFAs (to calculate measurement invariance), multiple linear regressions, and moderations were performed. Results showed that pro-environmental behavior and climate change hope achieved the four assessed levels of invariance across different political orientations; climate change anxiety achieved the first three levels of invariance; and climate change perception and climate change despair achieved configural invariance. Climate change anxiety, personal experience with climate change, and climate change perception (total, reality, and consequences) presented higher values for the left political orientation than for the right or the center. Climate change anxiety variables contributed most to explaining pro-environmental behaviors. Hope, despair, and climate change perception (consequences) moderated the relationship between climate change anxiety and pro-environmental behavior. These results open up new avenues for investigation, specifically to understand why high levels of anxiety lead to more pro-environmental behaviors.
Different Results from Varied Angles: The Positive Impact of Work Connectivity Behavior After-Hours on Work Engagement
Authors: Yang Yang , Yan Rui , Li Xuehong , Meng Yan , Xie Guoqiang
Published: November 2023

With the development of communication technology and the COVID-19 pandemic, it has become increasingly common for employees to maintain work connectivity after-hours, which has a significant impact on their psychological state at work. However, most of the existing studies have not reached a consensus on the impact of work connectivity behavior after-hours on employees’ psychological state at work, and the existing studies have led to theoretical and practical disagreements. Based on the Job Demands–Resources model, we built a two-path model of work autonomy and emotional exhaustion to explore the impact of work connectivity behavior after-hours on work engagement. In addition, we compared the differences between different workplace statuses (managers and ordinary employees). Through surveys and analyses of 257 employees, the results show that work connectivity behavior after-hours positively impacts employees’ work engagement by increasing managers’ work autonomy and reducing ordinary employees’ emotional exhaustion. This study not only reveals that work connectivity behavior after-hours positively affects work engagement but also illustrates the differences in impact between managers and ordinary employees; these findings contribute to the development of a consensus on the influence of work connectivity behavior after-hours on employees’ psychological state at work, which provides insights for organizations seeking to manage work connectivity behavior after-hours, for example, by adopting different connectivity management strategies for employees with different workplace statuses.
Analysis of Convergent Validity of Performance-Based Activities of Daily Living Assessed by PA-IADL Test in Relation to Traditional (Standard) Cognitive Assessment to Identify Older Adults with Mild Cognitive Impairment
Authors: Fernández María Paula , Labra José Antonio , Menor Julio , Alegre Eva
Published: November 2023

Difficulty in performing instrumental activities of daily living (IADLs) is currently considered an important indicator of cognitive impairment in the elderly. A non-experimental case–control investigation was conducted to assess the convergent validity of the PA-IADL with traditional (standard) cognitive assessment tests in its ability to identify adults with mild cognitive impairment. The analysis of the data was carried out by means of various multivariate statistical tests, and the sequence in its execution led to the conclusion that 8 of the 12 Tasks that make up the PA-IADL allow for the identification of people with mild cognitive impairment (MCI) to the same extent as traditional cognitive assessment tests and regardless of age. Age was found to be a moderating variable in the performance of the eight tasks; however, the results allow us to hypothesize that people with MCI experience a significant decline when it happens but thereafter, the deterioration that occurs does so at the same rate as the deterioration experienced by healthy people. They also allow us to hypothesize that the difference in the cognitive skills required by the eight functional tasks, and therefore also in the cognitive skills required by the traditional (standard) tests of a person with MCI compared to a person of the same age without MCI (Healthy), is approximately 10 years. These hypotheses have remarkable relevance and should be tested via longitudinal research. In the meantime, the results highlight the importance of the IADL assessment for the diagnosis of MCI as a complement to the standard cognitive assessment.
The Identification and Dynamics of Urban Shadow Areas from the Perspective of People Flows—A Case Study of Nanjing
Authors: Xiong Weiting , Yang Junyan
Published: November 2023

Urban shadow areas, formed by long-term unbalanced and inadequate development during the rapid process of urbanization, are of great significance to a city’s overall development. However, relatively little attention has been paid to identifying and characterizing urban shadow areas. Drawing upon a dataset on urban morphology and cellular signaling, and taking Nanjing as a case study, this paper proposes a method to identify urban shadow areas from the perspective of people flows. The empirical results show that there are 19 urban shadow areas within the downtown areas of Nanjing, 11 of which are distributed in the old downtown areas and the rest are relatively scattered in the periphery. As for morphological characteristics, these urban shadow areas differ from each other in terms of indicators such as building density and development intensity. Moreover, the empirical results show that these urban shadow areas are not isolated but closely connected with other parts of Nanjing. Based on the different spatio-temporal distribution patterns of their connections, the 19 urban shadow areas are divided into four types, and the characteristics of each type have been investigated by analyzing a representative shadow area. It is suggested that policies aiming to eliminate the negative effects of urban shadow areas should consider heterogeneity in their spatial distributions within a city, the temporal distribution of their external connections, and their dominant functions.
Techno-Economic Analysis of the Energy Resilience Performance of Energy-Efficient Buildings in a Cold Climate and Participation in the Flexibility Market
Authors: Saini Ashish , Hasan Ala , Shemeikka Jari
Published: November 2023

Unexpected power outages and extreme weather encouraged research on energy-resilient buildings throughout the world. Resilient building research mainly focuses on hot weather rather than cold extremes. This study defines resilience terminologies based on the available literature and discusses the impact of energy efficiency on energy resilience performance in energy-efficient buildings due to abrupt power outages in an extremely cold climate. The assessment involves the case simulation of a multistory apartment located in southern Finland at design outdoor conditions (−26 °C) in IDA-ICE 4.8, a dynamic building simulation software, and its techno-economic assessment to ensure building resilience for up to 7 days of power outages. The assessment shows the efficient building envelope can enhance the time taken by the building to drop the indoor temperature to the threshold by approximately 15%. Additionally, the efficient heating system along with the building envelope can reduce the instantaneous power demand by up to 5.3 times, peak power demand by up to 3.5 times, and on average power consumption by 3.9 times. Similarly, the study finds that the total energy requirement during a blackout can be reduced by 4.1 times. The study concludes that enhanced building resilience is associated with energy-efficient parameters such as an efficient energy system and an efficient building envelope that has low thermal losses and high thermal inertia retention. The batteries contribute the maximum proportion to the overall retrofitting cost, and the proportion can go up to 70% in baseline configurations and 77% in efficient configurations of buildings. The analysis concludes that the required investment varies largely with the technologies involved and the combination of components of these energy systems. The assessment finds that the high investment costs associated with batteries and battery recharging costs are the main bottlenecks to feasible flexibility in market participation.
The Emergence of the Contractor’s Innovation Capability at Project Level: An Agent-Based Modeling Approach
Authors: Feng Jing , Liu Baijian , Tang Juanjuan , Wang Qing’e
Published: November 2023

Contractors play a crucial role in ensuring efficient innovation within construction projects but limited research has focused on the innovation capability of contractors. This study utilizes a multi-method approach, including case studies, surveys, and interviews to collect data for analysis. Based on this, a conceptual model is proposed and a simulation mode which utilizes agent-based modeling (ABM) is constructed. ABM is the microscopic bottom-up approach which can describe and follow the agents and interactions. This study proposes a novel conceptual model to examine the emergence of contractor innovation capability at the project level, from a knowledge flow perspective. It fills the research gap regarding innovation capability in temporary cross-organizational projects. Additionally, an ABM simulation model is developed considering project and participant characteristics, providing insights into the formation rule and development mechanisms of contractors’ innovation capability at the project level. The conclusions are as follows: (1) The demand for innovation drives the innovative behavior of different entities within the project. (2) Knowledge availability in public domains and other entities’ knowledge creation capability provide critical support for contractor innovation. (3) Contractors’ capability to absorb and integrate knowledge serves as the foundation for achieving innovation. (4) When contractors possess strong capabilities, effective synergy among organizations facilitates the generation of innovative outcomes.
Application of Graphic Statics and Strut-and-Tie Models Optimization Algorithm in Innovative Timber Structure Design
Authors: Gao Yuanben , Shao Yiliang , Akbarzadeh Masoud
Published: November 2023

Timber has long been extensively employed within the construction industry as a famous, environmentally friendly, and low-carbon material. Considering that construction constitutes one of the most significant contributors to carbon emissions throughout the entire life-cycle of a building, there is an urgent desire to incorporate timber into this domain. Nevertheless, the use of timber faces inherent challenges stemming from its anisotropic nature, a result of the natural growth of timber fibers, which makes it challenging for it to function as a primary load-bearing material in coping with the various complex stresses inherent in architectural applications. Numerous designers have attempted to address this limitation through over-sized members and reinforcement at joints; however, none have satisfactorily resolved this issue in an economical manner. In this article, we introduce the Strut-and-Tie models (STM) from Graphic Statics (GS) and a topological optimization algorithm. This algorithm has the capability to generate a ‘load-minimizing path’ STM based on external load support conditions and the maximum structural path span. Regardless of the complexity of the initial external loads, each load transfer path in the optimized STM bears loads in only one direction, representing an optimal solution with minimal internal loads that align seamlessly with the characteristics of timber. Consequently, we endeavor to adopt this optimization algorithm to propose a structural design methodology, with the aspiration of designing structural systems that harness the unique attributes of timber perfectly and applying them to various architectural scenarios. Ultimately, we conclude that structural systems designed based on optimized STM are adaptable to diverse architectural contexts, and when applied to small-scale buildings, this method can save approximately 20% of material consumption compared to conventional timber frame structures, while in the case of mid-rise to high-rise buildings, it can lead to a material savings of approximately 5%.
Assessment of Fee Variability among Built Environment Professionals in South Africa: A Comparative Analysis
Authors: Ramabodu Molusiwa
Published: November 2023

Project success has often been impacted by varying factors, such as conflict arising from managing stakeholders’ remuneration, especially bordering on the scale of fees. This paper delves into the intricate landscape of fee variability among built environment professionals in South Africa. By scrutinizing the most recent available data, this research sheds light on the nuanced fee structures prevalent in the industry. To conduct this investigation, a comparative analysis of fee scales across various professions in South Africa was performed. This research employed historical project cost data extracted from an extensive dataset, encompassing project values, fees, and fee percentages for diverse professions involved in projects from 2014 to 2022. This study revealed that low scale levels are associated with poor performance and lead to conditions and attitudes that pose dangers for consultants. This study provides strategies for a firm’s resilience and adaptability in the face of the dynamics associated with fees.
Real-World Treatment Outcomes and Safety of Afatinib in Advanced Squamous Cell Lung Cancer Progressed after Platinum-Based Doublet Chemotherapy and Immunotherapy (SPACE Study)
Authors: Ji Wonjun , Oh In-Jae , Park Cheol-Kyu , Lee Sung Yong , Choi Juwhan , Lee Jae Cheol , Kim Jiwon , Lee Seung Hyeun
Published: November 2023

This study aimed to evaluate treatment outcomes and safety of afatinib in patients with squamous cell carcinoma of the lung (LSCC) who progressed after chemotherapy and immunotherapy. We recruited patients both retrospectively and prospectively and collected the outcomes and safety data. Additionally, we performed next-generation sequencing using tumor tissue and/or plasma to explore potential molecular biomarkers. Altogether, 42 patients were included in the final analysis. The median number of prior treatments was three (range 1–8), and the median TTF was 2.1 months. Objective response rate and disease control rate were 16.2% and 59.5%, respectively, and median duration of response was 4.0 months among response evaluable patients (n = 37). Treatment-related adverse events (TRAEs, including diarrhea, stomatitis, and paronychia) occurred in 22 (52.3%) patients; however, most were grade 2 or lower, and only 5 cases were grade 3. TRAEs led to dose modification in 17 (40.5%) and discontinuation in 4 (9.5%) patients. The TTF in patients with ERBB2 mutations was significantly longer than that in patients without (6.8 vs. 2.1 months, p = 0.045). Our results highlight that afatinib is a reasonable treatment option in terms of effectiveness and safety, and ERBB2 mutation can be used as a predictive biomarker in clinical settings.
Tuning the Magnetic and Catalytic Properties of Manganese Ferrite through Zn2+ Doping: Gas Phase Oxidation of Octanol
Authors: Bibi Mehnaz , Sadiq Muhammad , Rizk Moustafa A. , Alsaiari Raiedhah A. , Iqbal Zaffar , Ali Zahid
Published: November 2023

Spinel ferrites, ZnFe2O4, MnFe2O4, and ZnMnFe2O4, were synthesized using the sol–gel method and thoroughly investigated for their potential as catalytic and magnetic materials. Experiments unveiled that ZnMnFe2O4 exhibited excellent catalytic and magnetic properties, whereas the Density Functional Theory (DFT) calculations provided insight into the excellent performance of ZnMnFe2O4 compared with ZnFe2O4 and MnFe2O4. The catalytic efficiencies of the synthesized spinel ferrites were evaluated against a model reaction, i.e., the gas-phase oxidation of octanol to a corresponding aldehyde, utilizing molecular oxygen as an oxidant. The results indicated that the order of catalytic activity was ZnMnFe2O4 > MnFe2O4 > ZnFe2O4. The reaction was found to follow Langmuir Hinshelwood’s mechanism for dissociative adsorption of molecular oxygen. Owing to their superb catalytic and magnetic properties, mixed ferrites can be extended to a variety of organic transformation reactions.
Cytological Study of Topical Effect of Azelastine Hydrochloride on the Nasal Mucous Membrane Cells in Various Nasal Rhinitis Types
Authors: Trybus Ewa , Trybus Wojciech , Król Teodora
Published: November 2023

Previous reports on the benefits of using local therapy with azelastine in rhinitis focus on the assessment of clinical symptoms and the analysis of nasal lavage for the presence of inflammatory cells and the expression of adhesion molecules. Little attention has been paid to studies assessing the effect of azelastine on individual cytotypes of the nasal mucosa, especially epithelial cells, also in the context of inducing morphological changes. The aim of this study was the cytological analysis of swabs taken from the surface of the nasal mucosa of patients with allergic rhinitis (AR) and nonallergic/vasomotor rhinitis (NAR/VMR) who were subjected to 4 weeks of therapy with azelastine and then comparing the obtained results with the pre-treatment condition. The technique of obtaining materials for cytoanalysis included sampling, staining of smears, microscopic analysis, and preparation of cytograms. Our studies confirmed the therapeutic benefits of azelastine in both study groups. Significant changes were demonstrated, confirming the regeneration of ciliated cells and the induction of autophagy and apoptosis in epithelial cells. Such changes indicate new mechanisms of action of azelastine, which play a significant role in restoring homeostasis in the nasal mucosa. The presented research also results in a detailed description of cytological changes in both studied rhinitis types, which complements the knowledge regarding prognostic indicators.
Cell Adhesion at the Tight Junctions: New Aspects and New Functions
Authors: Wibbe Nicolina , Ebnet Klaus
Published: November 2023

Tight junctions (TJ) are cell–cell adhesive structures that define the permeability of barrier-forming epithelia and endothelia. In contrast to this seemingly static function, TJs display a surprisingly high molecular complexity and unexpected dynamic regulation, which allows the TJs to maintain a barrier in the presence of physiological forces and in response to perturbations. Cell–cell adhesion receptors play key roles during the dynamic regulation of TJs. They connect individual cells within cellular sheets and link sites of cell–cell contacts to the underlying actin cytoskeleton. Recent findings support the roles of adhesion receptors in transmitting mechanical forces and promoting phase separation. In this review, we discuss the newly discovered functions of cell adhesion receptors localized at the TJs and their role in the regulation of the barrier function.
Hydroxyapatite-Resin Composites Produced by Vat Photopolymerization and Post-Processing via In Situ Hydrolysis of Alpha Tricalcium Phosphate
Authors: Oliver-Urrutia Carolina , Drotárová Lenka , Gascón-Pérez Sebastián , Slámečka Karel , Ravaszová Simona , Čelko Ladislav , Montufar Edgar B.
Published: November 2023

Vat photopolymerization is an additive manufacturing technique that utilizes photosensitive resins to fabricate 3D polymeric objects with high precision. However, these objects often lack mechanical strength. This study investigated the strengthening of a resin based on epoxidized soybean oil acrylate, specifically designed for vat photopolymerization, by the in situ formation of hydroxyapatite nanocrystals. First, a stable alpha tricalcium phosphate (α-TCP)-resin feedstock mixture was developed (~30 vol.% α-TCP), which proved suitable for fabricating monoliths as well as complex triply periodic minimal surface (gyroid, diamond, and Schwarz) porous structures through vat photopolymerization. The results demonstrated that the incorporation of α-TCP particles led to a significant mechanical improvement of the resin. Second, post-printing hydrothermal treatments were utilized to transform the α-TCP particles into hydroxyapatite crystals within the resin. It was observed that the space between hydroxyapatite crystals within the composites was occupied by the cured resin, resulting in a more compact, stronger, and mechanically more reliable material than the porous hydroxyapatite produced by the hydrolysis of α-TCP mixed with water. Moreover, water absorption during the hydrothermal treatments caused the plasticization of the cured resin. As a consequence, the hydroxyapatite-resin composites displayed slightly lower mechanical properties compared to the as-printed α-TCP-resin composite.
Maternal Pre-Pregnancy BMI and Gestational Weight Gain Are Associated with Preschool Children’s Neuropsychological Outcomes in the APrON Cohort
Authors: England-Mason Gillian , Anderson Alida , Bell Rhonda C. , Subhan Fatheema B. , Field Catherine J. , Letourneau Nicole , Giesbrecht Gerald F. , Dewey Deborah ,   The APrON Study Team
Published: November 2023

This study examined the associations between maternal pre-pregnancy BMI and gestational weight gain (GWG) and children’s neuropsychological outcomes at 3 to 5 years of age. A total of 379 women and their children from the Alberta Pregnancy Outcomes and Nutrition (APrON) study participated. Covariate-adjusted robust regressions examined associations between maternal pre-pregnancy BMI, GWG class, interaction terms, and child outcomes. Each unit increase in maternal BMI was linked to a 0.48-point decrement (95% CI: −0.75 to −0.21) in children’s Full Scale IQ. Higher pre-pregnancy BMI was related to poorer performance on the other intelligence indexes (B = −0.35 to −0.47, 95% CIs: −0.75, −0.02) and lower performance on measures of language (B = −0.08 to −0.09, 95% CIs: −0.16, −0.02), motor skills (B = −0.08 to −0.11, 95% CIs: −0.18, −0.01), and executive function (B = −0.09 to −0.16, 95% CIs: −0.26, −0.01). GWG below the recommended range was associated with a 4.04-point decrement (95% CI: 7.89, −0.11) in Full Scale IQ, but better performance on a spatial working memory test (B = 0.27, 95% CI: 0.02, 0.52). GWG above the recommended range was associated with lower language (B = −0.79, 95% CI: −1.52, −0.06) and memory scores (B = −0.93, 95% CI: −1.64, −0.22). Interactions were found between pre-pregnancy BMI and GWG on measures of intelligence and executive function. Maternal pre-pregnancy BMI and GWG are related to children’s performance in various neuropsychological domains and may interact to predict outcomes. Optimizing maternal health and weight prior to conception and during pregnancy may enhance children’s neuropsychological outcomes.
Environmental Influences on Individuals with Autistic Spectrum Disorders with Special Emphasis on Seasonality: An Overview
Authors: Botsas George , Koidou Eirini , Chatzinikolaou Konstantinos , Grouios George
Published: November 2023

This paper offers an in-depth exploration of the intricate relationship between environmental factors and autism spectrum disorder (ASD), with a special emphasis on seasonality. It reviews existing research, providing a comprehensive summary of findings and highlighting the multifaceted dimensions of several environmental factors influencing the etiology of ASD. The discussion encompasses various elements, including birth months, maternal health, dietary choices, and vitamin D deficiency, delving into the intricate interplay of seasonality with environmental influences such as viral infections and solar radiation. The present study raises essential questions regarding the timing of environmental influences and the factors contributing to the rising prevalence of ASD. Ultimately, it underscores the need for future epidemiological research to incorporate more extensive investigations of environmental risk factors and employ advanced statistical analyses. This comprehensive overview contributes to a deeper understanding of how environmental factors, particularly seasonality, may be linked to the occurrence of ASD and its increasing prevalence, recognizing the multifaceted and diverse nature of these interactions.
Engaging Parents Affected by Mental Health Problems in Pediatric and Gynecologic Practices—Implications of the KID-PROTEKT Study
Authors: Sigmund Désirée , Loew Viola , Pawils Silke
Published: November 2023

Children of parents with mental illness are at higher risk of developing cognitive, mental health or physical health difficulties. Previous studies have described several barriers for reaching parents with mental health problems (MHPs) and their utilization of psychosocial services. We conducted a cluster randomized controlled study in 24 pediatric and gynecologic practices to evaluate KID-PROTEKT, a psychosocial healthcare intervention that comprises a psychosocial assessment to identify families with psychosocial needs and refer them to support services. In this paper, we analyzed whether psychosocially distressed parents with additional MHPs (identified by the PHQ-9 and GAD-7) had higher support needs, could be referred to support and utilized it in comparison to parents with psychosocial burden only. In total, 178 pregnant women and mothers with psychosocial burden were included, of whom 55 had MHPs. Participants with MHPs were distressed in their relationships more often and medical staff rated their level of support needs higher compared to parents without MHPs. There were no significant differences between the groups regarding whether they were referred to support services or utilized the recommended services. All participants were most frequently referred to family or parent counseling/care or childcare assistance. The results indicate that despite existing barriers, parents with MHPs could be reached and identified by the KID-PROTEKT psychosocial assessment. A psychosocial intervention like KID-PROTEKT can help to provide support for mentally ill parents.
Stress, Professional Burnout, and Employee Efficiency in the Greek National Organization for the Provision of Health Services
Authors: Vlassi Alexandra , Vitkos Evangelos , Michailidou Despoina , Lykoudis Panagis M. , Kioroglou Lambrini , Kyrgidis Athanassios , Tilaveridis Ioannis , Dardavesis Theodoros
Published: November 2023

Background: Workplace stress and burnout in the Greek healthcare system had been considered severe even before the high pressure of the COVID-19 pandemic. We aimed to investigate occupational quality of life and burnout effects on workplace errors among the administrative staff in the Greek healthcare system. Methods: We enrolled 120 administrative healthcare employee participants between April and May 2019. Occupational burnout was assessed using the Maslach Burnout Inventory—Human Services Survey and the Hospital Anxiety and Depression Scale. Findings: Inadequate staffing, a low sense of well-being, exhaustion, and low family income were associated with workplace errors. Increased workload and staff shortages were associated with occupation related quality of life. Conclusions: Targeted interventions supporting healthcare staff mental health are warranted. Application to Practice: Wellness and professional burnout can affect professional efficiency and are associated with workplace errors in the healthcare sector. Targeted interventions are warranted to support the mental health of healthcare staff during work and to prevent incidents of post-traumatic stress. Shortages of staffing may lead to an increase in the cost of the provided services.