bluuebunny/crossref_metadata_2025 huggingface dataset:
Modelling phosphorus inflow to the Mozhayskoe reservoir with the HYPE hydrological model
Authors: Yasinskiy Nikolay S. , Erina Oksana N. , Sokolov Dmitry I. , Belolubtsev Alexander I.
Published: December 2019

Biogenic flow is the determining factor of ecological well-being of water bodies. It depends on a number of factors, such as weather conditions, soil and vegetation cover, agricultural use of the catchment area. Its simulation is possible based on a complex water quality model with parameters distribution. In this paper, we show that the model calculates the water flow with satisfactory accuracy and gives reliable values of phosphorus flow in the investigated river outlet. The influence of dryness of the year on the phosphorus flow is important and reduces dissolved phosphorus flow several times. The results of experiments with the model show a decrease of dissolved phosphorus flow subsequent to cease of fertilizing in range from 5 to 11%. The values of the surface and groundwater genetic components of phosphorus flow are comparable, while soil component amounts 65% of local phosphorus flow.
Aerosol and Its Radiative Effects during the Aeroradcity 2018 Moscow Experiment
Authors: Chubarova Natalia E. , Androsova Elizaveta E. , Kirsanov Alexandr A. , Vogel Bernhard , Vogel Heike , Popovicheva Olga B. , Rivin Gdali S.
Published: December 2019

During the AeroRadCity-2018 spring aerosol experiment at the Moscow State University Meteorological Observatory the aerosol properties of the atmosphere and radiative aerosol effects were analyzed using a wide complex of measurements and model COSMO-ART simulations over Moscow domain. The program of measurements consisted of columnar aerosol AERONET retrievals, surface PM10, black carbon (BC) and aerosol gas precursors mass concentrations, as well as radiative measurements under various meteorological conditions. We obtained a positive statistically significant dependence of total and fine aerosol optical depth (AOD) mode (R2 ~0.4) with PM concentrations. This dependence has revealed a pronounced bifurcation point around PM10=0.04 mgm-3. The modelled BC concentration is in agreement with the observations and has a pronounced correlation with PM, but not with the AODs. The analysis of radiative effects of aerosol has revealed up to 30% loss for UV irradiance and 15% - for shortwave irradiance at high AOD in Moscow. Much intensive radiation attenuation is observed in the afternoon when remote pollution sources may affect solar fluxes at elevated boundary layer conditions. Negative (cooling) radiative forcing effect at the top of the atmosphere from -18 Wm-2 to -4 Wm-2 has been evaluated. Mean difference in visible AOD between urban and background conditions in Moscow and Zvenigorod was about 0.01 according to measurements and model simulations, while in some days the difference may increase up to 0.05. The generation of urban aerosol was shown to be more favorable in conditions with low intensity of pollutant dispersion, when mean deltaAOD550 was doubled from 0.01 to 0.02.
Var Adam ekki lengi í helvíti? Hafa stjórnunarhættir á Íslandi breyst eftir hrunið 2008?
Authors: Óladóttir Ásta Dís , Magnússon Gylfi
Published: December 2019

Íslensk fyrirtæki fóru mikinn á árunum fyrir efnahagshrunið árið 2008 og fjárfestingar stjórnenda skiluðu Íslandi í efsta sæti á hinum alþjóðlega World Investment Report lista ár eftir ár. „Mig er farið að klæja í puttana að loka nýjum díl, við höfum ekkert gert á þessu ári,” var eitt af þeim svörum sem komu fram í rannsóknum höfunda fyrir hrunið enda fjárfestu íslenskir stjórnendur meira en aðrir og iðulega í stærri fyrirtækjum en þeim sem þeir störfuðu fyrir. Eignarhald á hlutabréfum í aðdraganda hruns einkenndist mjög af skuldsetningu hluthafanna. Mikil vogun varð til þess að eigendur skráðra félaga urðu afar viðkvæmir fyrir niðursveiflum á hlutabréfamarkaði enda veðjuðu þeir djarft á öra hækkun. Það þýddi jafnframt mikla pressu á stjórnendur sem urðu helst að skila sífellt glæsilegri niðurstöðum í ársfjórðungsuppgjörum til að stuðla að endalausri hækkun hlutabréfaverðs. Í greininni er skoðað hvort stjórnunarhættir hafi breyst í íslensku viðskiptalífi frá hruni. Rannsóknin náði til 42 stjórnenda á lista yfir 300 stærstu fyrirtæki landsins. Voru þeir m.a. spurðir hvort stjórnunaraðferðir þeirra hefðu eitthvað breyst eftir hrunið 2008. Margar rannsóknir liggja fyrir um aðferðir og einkenni góðra stjórnenda og rannsóknir á aðferðum íslenskra stjórnenda á árunum fyrir hrun bentu til þess að þeir væru áhættusæknir og fljótir að taka ákvarðanir. Sjálfstraustið var mikið, birtist jafnvel sem hvatvísi. Þá virtist skortur á langtímastefnumótun. Rannsóknarspurningin sem hér er sett fram er hvort aðferðir (stjórnunarhættir) íslenskra stjórnenda hafi breyst eftir efnahagshrunið árið 2008. Í ljós kom að stjórnendur í íslensku atvinnulífi eru sammála um að margt hafi breyst í stjórnunarháttum frá því fyrir hrun, óttinn við mistök hafi verið alls ráðandi í atvinnulífinu fyrst eftir hrunið og um tíma dró úr áhættusækni stjórnenda. Tíu árum síðar séu hlutirnir að nálgast ört það sem áður var, þótt hugsanlega sé aðeins meiri varkárni við ákvarðanatöku, meira regluverk og formfesta og meiri áætlanagerð en var. Skuldsetning virðist minni en var á árunum fyrir hrun, þó eru margir stjórnendur á því að rúmum 10 árum eftir hrun sé allt að fara í svipað horf og það var. Bægslaganginum sé þó núna að mestu haldið bak við tjöldin.
NUTRITIONAL STATUS AND SELF-REPORTED NUTRITION EDUCATION EXPOSURE IN WOMEN WITH GESTATIONAL DIABETES MELLITUS AT PRIMARY HEALTH CLINIC
Authors: Samiun Nurul Alia Aqilah , Mohd Yusof Barakatun Nisak , Ismail Irmi Zarina , Anuar Farhanah , Chee Winnie Siew Swee
Published: December 2019

Background: Optimal nutritional status is of utmost importance not only for foetal development but also to maintain normoglycemia in women with gestational diabetes mellitus (GDM). This cross-sectional study described the nutritional status of women with GDM and explored whether self-reported nutrition education (NEd) exposure before a GDM diagnosis would be able to promote better nutrition status.

Methods: GDM women (n= 60; age= 31.6 ± 5.0 years) diagnosed between 13th and 28th week of gestation participated in the study. We assessed nutritional status that included anthropometric and blood pressure assessments, biochemical data, and dietary intake. The respondents self-reported their NEd exposure before a GDM diagnosis was made.

Results: The pre-pregnancy BMI of the participants was 27.9 ± 6.8 kg/m2, which was categorised as overweight. Total (4.3 ± 5.6 kg) and rate (0.2 ± 0.3 kg/week) of gestational weight gain were within the recommendations. Glycemic parameters and blood pressure were also within the normal range. Nevertheless, they had high intakes of fat (35.5%) and sugar (14.4%) proportionate to their energy intake. They did not meet the recommended nutrient intakes for fibre, calcium, and iron. Only 28.3% of women had prior NEd exposure.  Among them, almost all (94.1%) had recurrent GDM. Those with NEd exposure had lower pre-prandial blood glucose profiles, systolic blood pressure, and proportion of protein intake from energy than those without (p< 0.05).

Conclusion: Suboptimal maternal nutritional status and low exposure to NEd are evident in women with GDM. Those with self-reported NEd exposure had better parameters of nutritional status. The findings recognised the need of having proper nutrition education for women who are at high risk of GDM since at early pregnancy.
Massive, Spontaneous Ruptured Renal Subcapsular Haematoma Following Thrombolytic Therapy in Acute ST-Elevation Myocardial Infarction
Authors: Raja Shariff Raja Ezman Faridz , Kasim Sazzli Shahlan
Published: December 2019

Background: Thrombolytic therapy remains widely used in majority of developing countries, where delivery of primary percutaneous coronary intervention (PCI) remains a challenge. Unfortunately, complications following such therapy remains prominent, predominantly bleeding-related problems. We present a rare case of massive renal subcapsular haemorrhage and hematoma following thrombolytic therapy. Case Report: A 61-year old gentleman presented following an episode of chest pain due to acute ST-elevation myocardial infarction. Due to potential delays in obtaining PCI, the patient was counselled for thrombolysis using streptokinase which he had consented to. Unfortunately, within 36 hours of admission, he developed abdominal pain, haematuria, hypotension and altered mental status, associated with acute drops in haemoglobin levels. Following initial resuscitation efforts, a Computed Tomography scan of the abdomen was performed revealing a massive renal subcapsular hematoma, likely secondary to previous thrombolysis. Discussion: Renal subcapsular hematoma can either be spontaneous or iatrogenic, the latter often due to coexisting renal-based neoplasm or vasculitidies. Iatrogenic causes include trauma, following renal biopsies or anticoagulation therapy amongst a few others. Iatrogenic renal subcapsular haemorrhage and hematoma formation are rare following thrombolysis. Our literature search revealed only one other similar case, although this was following administration of recombinant Tissue Plasminogen Activator in a case of acute ischaemic cerebrovascular accident. Conclusion: This case highlights the complexity in management, following the findings in terms of need for cessation of dual antiplatelet therapy and timing for PCI and stent selection.
Penerapan Program Pengembangan Kewirausahaan Pada Mahasiswa (Tenant) di Universitas Kanjuruhan Malang
Authors: Budianto Alexius Endy , Dianawati Eris , Iswahyudi Didik
Published: December 2019

The implementation of the Entrepreneurship Development Program (PPK) at Kanjuruhan University in Malang is expected to achieve the objectives of: (1) creating start-ups and independent new entrepreneurs, (2) improving business management skills for industrial communities, (3) creating entrepreneurship training methods suitable for students , (4) business units that can generate profit as a source of generating revenue from Kanjuruhan Malang University, and (5) opening or providing employment. The stages in implementing PPK include: (1) Dissemination of the PPK program, this socialization is carried out through announcements on campus boards, campus websites, and social media (Student groups and Alumni Groups). (2) Participants register before they enter the PPK tenant. (3) Following a written test to see the scientific potential possessed about the world of entrepreneurship, followed by interviews to find out the motivation and seriousness of participants in the PPK program. (4) The results of the selection will determine 20 best value people as prospective tenants. (5) Participants must fill out the willingness sheet to complete the PPK  program to completion. Whereas specifically to be achieved are: soul growth and entrepreneurial culture on campus, increased ability to prepare business plans, development of products that have been produced by tenants after participating in PPK activities, the creation of innovative and renewable products. The program will be implemented in a participatory manner with knowledge transfer methods from the proposing team, business experts, UMKM players to PPK tenants through education and training, business simulations, internships, intensive assistance, preparing business plans, and applying business to the tenants' potential and talents.
KELOMPOK PENDAMPING STIMULASI PRODUKSI ASI (KP-STIPASI) BERBASIS COMMUNITY SUPPORT DI KELURAHAN KARANGROTO SEMARANG
Authors: Wuriningsih Apriliani Yulianti , Khasanah Nopi Nur , Puspita Sari Dyah Wiji
Published: December 2019

Air susu ibu (ASI) merupakan nutrisi terbaik untuk kesehatan bayi. World Health Organisation (WHO) dan United Nations Children’s Fund(UNICEF) merekomendasikan pelaksanaan inisiasi menyusui dini (IMD), pemberian ASI eksklusif selama 6 bulan pertama kehidupan, dan terus menyusui sampai usia 24 bulan sebagai strategi penting untuk mengurangi kematian bayi, khususnya di negara berkembang. Tujuan kegiatan Kelompok Pendamping Stimulasi Produksi ASI (KP-STIPASI), yaitu meningkatkan pemahaman, kesadaran, dan keterampilan ibu hamil di Kelurahan Karangroto untuk mempersiapkan proses menyusui dan ASI eksklusif. Metode pelaksanaan terdiri dari sosialisasi, peningkatan kompetensi, latihan ketrampilan, monitoring dan evaluasi. Hasil kegiatan menunjukkan bahwa terbentuknya forum diskusi kader kesehatan dengan fokus kegiatan pada ibu hamil untuk mempersiapkan proses menyusui di bawah binaan Puskesmas Bangetayu, meningkatnya kemampuan dan ketrampilan kader kesehatan dalam menstimulasi produksi ASI dari 25% menjadi 87%, meningkatkan prenatal breastfeeding self efficacydari 35% menjadi 85%. KP-STIPASI berbasis community supportmenjadi strategi yang tepat untuk memberdayakan masyarakat dalam meningkatkan kesiapandan keyakinan ibu hamil untuk menyusui eksklusif (prenatal breastfeeding self efficacy). Kegiatan PKM selanjutnya diharapkan dapat mengembangakan KP-STIPASI berbasis community supportdi seluruh RW Kelurahan Karangroto. Kegiatan tidak hanya berfokus pada ibu hamil, namun juga pada ibu yang memiliki anak berusia di bawah dua tahun (baduta) dan ibu menyusui.
PEMBERDAYAAN INDUSTRI PENGELOLAAN BANK SAMPAH BERAKSI BERBASIS GREENPRENEURSHIP DI BANK SAMPAH BERAKSI DESA POJOK
Authors: Nugrahaningsih Putri , Sari Vita Kartika , Hapsari Andi Asri
Published: December 2019

Bank  Sampah Beraksi di dukuh Selo, Desa Pojok, Kecamatan Tawangsari, Kabupaten Sukoharjo ini telah memiliki rumah bank sampah yang bertujuan untuk memaksimalkan pengelolaan bank sampah. Dari pengelolaan bank sampah ini, warga mulai teredukasi untuk  secara kreatif memanfaatkan sampah  yang bisa didaur ulang untuk bahan kerajinan tangan yang memiliki potensi ekonomis komersil disamping pemanfaatan untuk internal dekorasi galeri seni di kampung. Potensi tersebut dapat dimaksimalkan dengan mengolah sampah menjadi produk-produk yang kreatif-inovatif dan berdaya jual tinggi. Konsep pengelolaan sampah berbasis masyarakat akan semakin meningkatkan nilai tambah, ketika masyarakat mempunyai mindset greenpreneurship, yaitu konsep kewirausahaan yang memberikan kontribusi terhadap lingkungan. Program ini diharapkan akan menumbuhkankembangkan kecintaan terhadap lingkungan dengan cara yang bertanggungjawab sekaligus memberdayakan potensi untuk dikembangkan. Indikator hasil pengabdian diantaranya (1) tingkat kehadiran dan antusiasme peserta tinggi, (2) daya serap materi pelatihan peserta menggembirakan. 2) Target output pelatihan tercapai yang ditandai dengan terwujudnya produk kerajinan yang dihasilkan oleh para peserta. 3) Keberhasilan tersebut didukung oleh kompetensi dan komitmen tinggi dari pelatih.  The Garbage Bank “Beraksi” in the Selo hamlet, Pojok Village, Tawangsari District, Sukoharjo Regency already has a garbage bank house that aims to maximize the management of the garbage bank. From the management of this garbage bank, residents have begun to be educated to creatively utilize recyclable waste for handicraft materials that have commercial economic potential besides the utilization for internal decoration of art galleries in the village. This potential can be maximized by processing waste into creative-innovative and high-selling products. The concept of a community-based waste management will further increase the added value, when the community has a mindset of green entrepreneurship, namely the concept of entrepreneurship that contributes to the environment. The program is expected to foster a love for the environment in a way that is responsible while empowering the potential to be developed. Indicators of the results of devotion include (1) the level of attendance and enthusiasm of participants is high, (2) the absorption of participants' training materials is encouraging. 2) The training output target is achieved which is marked by the realization of handicraft products produced by the participants. 3) The success is supported by competence and high commitment from the trainer.
EDUKASI ANAK BINAAN SANGGAR WARINGIN TENTANG BULLYING MELALUI PENYULUHAN DENGAN METODE SOSIODRAMA
Authors: Mufidi Achmad Faidz , Salsabilla Tiara , Khairunnisa Muthia Fadhila , Gunawan Galuh Hanesty , Wibowo Hery
Published: December 2019

Sanggar Waringin merupakan rumah singgah bagi anak jalanan di lingkungan rentan dekat Stasiun Bandung. Penelitian research and development ini bertujuan untuk melakukan uji coba metode sosiodrama yang dapat digunakan dalam mengedukasi anak yang membutuhkan perlindungan khusus tentang bullying. Metode sosiodrama digunakan berdasarkan Social Learning Theory yang menyatakan bahwa perkembangan perilaku manusia terbentuk berdasarkan apa yang mereka alami di kehidupan. Sampel yang digunakan adalah 15 anak binaan Sanggar Waringin dengan rentang umur 5-13 tahun. Hasil penelitian ini menunjukkan bahwa sosiodrama dapat menjadi salah satu metode yang digunakan untuk memberikan penyuluhan kepada anak-anak, dengan catatan perlu ada visualisasi terlebih dahulu agar anak dapat lebih paham tentang materi yang diberikan.Sanggar Waringin is a place for street children that are in a vulnerable environment near Bandung Station. This research aims to test the sociodrama method that can be used for educating children in need of special protection about bullying. Sociodrama is used based on the Social Learning Theory which states that the development of human behavior is formed based on their life experiences. 15 children in Sanggar Waringin around the ages of 5-13 years old were used as the sample. The results of this study indicates that sociodrama can be used as one of the methods that provide counseling to children, but there is a visualization needed in advance so the children can understand the material well.
THE IMPLEMENTATION OF POSITIVE BEHAVIOR SUPPORT THROUGH CHAMPS TO IMPROVE STUDENT BEHAVIOR
Authors: Suwandi Lupita Jane
Published: December 2019

An effective classroom is one that runs smoothly with a few disruptions. In fact, based on the observation at grade 4 XYZ school, the researcher found that students frequently did inappropriate behavior such as calling out, excessive talking, forgetting to raise the hand quietly when asking question or stating an idea. One factor that made it happen was because the students did not clearly know about the teacher’s behavior expectation. Facing these problems, the researcher decided to use a preventive way to minimalize the students’ misbehavior using the CHAMPS approach which is a part of Positive Behavior Support. The purpose is to find out whether the students’ behavior will be improved by the implementation of CHAMPS as an expectation before the lesson started. The method of this research was Classroom Action Research (CAR) which consisted of two cycles and involved 20 students. The instruments that used were the teacher’s rating scale, student’s attitude scale, and researcher’s journal reflection. Descriptive statistical analysis and qualitative descriptive analysis were the technique used to analyze the data. From the data that has been analyzed, the researcher concluded that the implementation of Positive Behavior Support using CHAMPS had been improved student behavior in the classroom, specifically in their compliance towards the classroom rules and procedures. In short, despite its weaknesses and limitation, CHAMPS can be an alternative to minimalize students’ misbehavior and improve students’ behavior in the classroom.
PENERAPAN THINK, TALK, AND WRITE UNTUK MENINGKATKAN KEMAMPUAN BERPIKIR KRITIS DAN HASIL BELAJAR IPS SISWA KELAS VIII SMP KRISTEN SATYA WACANA SALATIGA
Authors: Klarita Endy Liani , Sadjiarto Arief
Published: December 2019

This research was conducted with problems in class VIII students, amounting to 20 students at the Satya Wacana Christian Middle School in Salatiga regarding critical thinking skills and learning outcomes. Therefore researchers want to take action to improve learning by using the Think Talk and Write (TTW) model. This type of research is the study of class action using Kurt Lewin's research design. The instrument of data collection uses test instruments, observation sheets, and questionnaires. Analysis of the data used is descriptive comparative. The indicator of the success of critical thinking skills and learning outcomes is 75%. The results obtained from this study are that there is an increase in critical thinking skills and learning outcomes of class VIII Satya Wacana Christian Middle School Salatiga. In the first cycle the results of critical thinking skills are 55% of students who have high critical thinking skills, while in the second cycle there is an increase of 85% of students who have high critical thinking skills. Then in the pre-cycle learning outcomes there were 25% of students whose grades reached KKM, the first cycle there were 70% of students completed KKM, and in the second cycle there was an increase of 90% of students who completed KKM. So the conclusion in this study that the use of Think Talk and Write (TTW) learning model can improve critical thinking skills and student learning outcomes in social studies subjects of class VIII Satya Wacana Christian Middle School Salatiga.
Modern methods for the development of new drugs that affect the hemostatic system
Authors: Sulimov A. V. , Kutov D. C. , Tashchilova A. S. , Ilin I. S. , Podoplelova N. A. , Panteleev M. A. , Ledeneva I. V. , Shikhaliev Kh. S. , Sulimov V. B.
Published: December 2019

The blood coagulation system plays an important role in health and disease. It is a complex network of proteolytic reactions that is activated during injuries and controls the formation of a fibrin clot. Although new components and reactions have not been discovered for thirty years, during this time there has been a revolution in understanding of how this system works and what enzymes are the optimal targets for the therapy. At the same time, new methods of drug development, first of all, computer docking, which are ideally suited for the discovery of inhibitors of blood clotting enzymes, have appeared. In this review, an attempt has been made to correlate the lines of development of new ideas about the mechanisms of coagulation, new methods of searching for drugs and their combination, thanks to which now there are more and more potentially interesting molecules that can change the face of the anticoagulant therapy in the near future. In the review, molecular modeling methods, primarily docking, which are increasingly used at the initial stage of developing new drugs, the role of docking at the initial stage of developing new inhibitors are briefly considered and the structure of the active centers of factors Xa and XIa, which determines their interaction with inhibitors, are discussed in detail.
Тhe role of surgery in treatment of patients with neuroblastoma of difficult anatomical localization
Authors: Sukhov M. N. , Sokolov S. V. , Narbutov A. G. , Lyvina I. P. , Andreev E. S. , Ponomareva N. I. , Skorobogatova E. V. , Bryzzheva I. A. , Komarova T. N. , Isaeva M. V.
Published: December 2019

High risk of life threatening complications is distinctive for surgery of tumors, which are in contact with large main vessels. Planning for the removal of the primary focus of neuroblastoma (NB), characterized by similar localization, includes determining the timing and method of the operation, the required resection volume, predicting complications, developing ways to prevent them and relieve them. The study was approved by the Independent Ethics Committee and Scientific Board of N.I. Pirogova of RussianNationalResearchMedicalUniversity. The results of complex treatment of 11 children with NB of thoracoabdominal localization, aged from 9 to 55 months, are present in the research. 7 (64%) of them were stratified into a high-risk group, 3 (27%) – intermediate, 1 (9%) – low, according to the criteria of the NB-2004 protocol. The results were analyzed depending on the features of the operation and the course of the early postoperative period. The number of variants of tumor syntropy which coincided image-defined risk factors, revealed by computed tomography with contrast enhancement, was in the range from 2 to 7 (median – 5). The median volume of the removed part of the tumor was 95% (range from 92 to 98%). Among intraoperative complications aortic wall (1 (9%) observation), superior mesenteric vein (1 (9%) observation), right renal vein (2 (18%) observations), left renal vein (2 (18%) observations), inferior vena cava (2 (18%) observations) injury should be noted, which were sutured without subsequently detected hemodynamic disturbances and organ function. Complications in the early postoperative period were: partial ileus (1 (9%) observation), renal artery thrombosis (1 (9%) observation), inferior vena cava thrombosis (1 (9%) observation), pancreatic necrosis (1 (9%) observation). They demanded reoperation in two children: nephrectomy in a child with renal artery thrombosis at the fourth posroparative day and performing of anastomosis between the pancreas and small intestine at the 74 posroparative day in a patient with pancreatic necrosis. Among patients in the intermediate and high-risk groups, the event-free two-year survival rate was 50%, the total two-year survival rate was 88%. The prognosis of the disease does not reliably correlate with the duration of the relief of postoperative complications (p = 0.53) and the resection volume (p = 0.46). Surgical intervention and postoperative observation in children with NB of thoracoabdominal localization should be carried out by a team that has experience of similar operations, owning vascular suture technique, with a preliminary assessment of the image-defined risk factors. The purpose of the operation should be a resection aimed at cytoreduction and elimination of the mass-effect, without striving to remove all areas of the tumor.
Comparison of total body irradiation using TomoTherapy and volume-modulated rotational radiation therapy Elekta. A single center experience on pediatric patients
Authors: Loginova A. A. , Kobyzeva D. A. , Tovmasyan D. A. , Chernyaev A. P. , Lisovskaya А. О. , Maschan M. A. , Nechesnyuk A. V.
Published: December 2019

This study presents the experience of one center in the development and implementation of two different methods of totalbody irradiation (ТОТ) based on radiation therapy with intensity modulation, namely, Helical TomoTherapy (HT) and Volumetric Modulated Arc Therapy (VMAT), implemented on the classic linear accelerator Elekta Synergy. The aim of the work is the comparison of two TBI methods, as well as a description of the process of introducing these methods into the routine practice of the radiotherapy department. The study was approved by the Independent Ethics Committee of the Dmitry Rogachev Nationa Medical Research Center of Pediatric Hematology, Oncology and Immunology. Prescribed total doses: PTV – 12.0 Gy with a single fraction of 2.0 Gy twice per a day, at least 95% of PTV should have received a dose of 11.4 Gy, the volume of each lung receiving 8.0 Gy should not exceed 40%, the average dose in each of the kidneys should not exceed 9.0 Gy, the dose in the anterior segment of the eye should be reduced as much as possible while maintaining the dose in surrounding part of PTV. In total, from July 2014 to December 2018, 156 patients received TBI, 128 of which on TomoTherapy and 28 on Elekta. The use of a standardized approach to TBI from July 2015 to December 2018 made it possible to introduce TBI into the routine practice of the radiotherapy department. A standardized approach to TBI was implemented with the irradiation of 17 on Elekta and 91 on TomoTherapy. It allowed us toobtain uniform reproducible results in terms of dosimetric criteria. The volume of lungs receiving a dose of 8.0 Gy did not exceed 40% for TomoTherapy and for Elekta, the average dose in the kidneys did not exceed 8.0 Gy for both modalities. In the standardized versions of TBI, 10.0 Gy cover at least 95% of the ribs volume, in accordance with the prescription. In both cases, the quality of PTV coverage met the prescribed criteria, namely, at least 95 percent of the volume of PTV received at least 95% of the prescribed dose (11.4 Gy). The minimum dose in the lungs was 6.2 ± 0.2 Gy and 5.1 ± 0.4 Gy, for TomoTherapy and Elekta respectively. The presence or absence of the clinical significance of this criterion is to be assessed. The developed TBI methods allow to deliver the prescribed dose to the target while maintaining the specified dose levels in the organs at risk. However, TomoTherapy plans have better target coverage and homogeneity than VMAT-based plans for Elekta. The use of a standardized approach makes it possible to quantify treatment plans for these techniques.
Hepatoblastoma relapses with a normal level of alpha-fetoprotein: report of two cases
Authors: Kachanov D. Yu. , Aliev T. Z. , Moiseenko R. A. , Roschin V. Yu. , Metelin A. V. , Uskova N. G. , Shamanskaya T. V. , Filin A. V. , Varfolomeeva S. R.
Published: December 2019

Hepatoblastoma (HB) is the most common malignant liver tumor in children. The level of alpha-fetoprotein (AFP) is used for monitoring the response to antitumor therapy and for diagnosing relapses. The occurrence of HB relapses with normal AFP levels in patients who had elevated levels of this tumor marker at disease onset is considered to be an uncommon situation. The aim of this study was to describe cases in which AFP-negative hepatoblastoma relapses developed. The study participants included two HB patients who were initially stratified into high-risk and standard-risk groups and who received treatment at the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology and the Petrovsky National Research Center of Surgery inMoscow. At the moment of relapse acknowledgement these patients had normal AFP levels, which was confirmed by serial measurements. Immunohistochemistry (IHC) tests were performed on paired samples of the tumor at disease onset and at disease relapse respectively to evaluate AFP expression. The presented clinical cases demonstrate that normal AFP levels, when accompanied by suspicious clinical symptoms, do not allow to exclude an HB relapse. The possibility of relapse with a normal AFP level reinforces the importance of following the current plan of screening tests, which includes not only an evaluation of AFP levels, but also other tests such as a chest X-ray and an abdominal ultrasound. Parents gave their consent to use information about the child in the article.
Penerapan Syariat Islam dari Sudut Pandang Media dan Perempuan di Aceh
Authors: Maulina Putri
Published: December 2019

The discourse of the Sharia implementation in Aceh in the context of media places women as the most reported group. Serambi Indonesia is one of the local print media that has intensively covered the enforcement of Sharia in Aceh. This study aims to look at the discourse of Sharia enforcement in local media and how the female audiences as active audiences interpret the discourse conveyed by the media. The theoretical approach used in this study is Reception Analysis. This study is descriptive qualitative research. Data were collected using Ferdinand de Saussure’s semiotics on six news articles of Serambi Indonesia throughout 2014 and in-depth interviews with eight female informants who were selected by purposive sampling technique. The results of the study illustrated that the dominant discourse in the media was women in Aceh were prone to violate Sharia. Findings also documented the tendency of informants to occupy oppositional reading positions that the way Serambi Indonesia covered Shariain Aceh was more likely to discriminate against women.
Instant Personal Branding Calon Legislatif Melalui Instagram
Authors: Nurhalimah Nurhalimah , Turistiati Ade Tuti
Published: December 2019

This research aims to analyze the personal branding of M. Yoridho Sinuraya, the legislative candidate for DPRD DKI Jakarta through Instagram. The theory of dramaturgy by Erving Goffman was used to find out personal branding strategy through the employment of the front and backstages of M. Yoridho Sinuraya as a legislative candidate for the Jakarta council (DPRP DKI Jakarta). Based on interviews and observation of Instagram account @sahabatyoridho, it showed that the front stage of M. Yoridho A. Sinuraya had the characteristics of being a friendly, young, pious, and populist man. Meanwhile, the back stage of M. Yoridho A. Sinuraya had characteristics as a young entrepreneur who was lack of interaction with other people and had a semi-formal appearance. The difference between the front and back stages of M. Yoridho A. Sinuraya made him take extra efforts to develop his personal branding, classified as an instant one.
Cyber-SHIP: Developing Next Generation Maritime Cyber Research Capabilities
Authors: Tam K , Forshaw K , Jones KD
Published: December 2019

As a growing global threat, cyber-attacks can cost millions of dollars or endanger national stability and human lives. While relatively well understood in most sectors, it is becoming clear that, although the maritime sector is becoming more digitally advanced (e.g., autonomy), it is not well protected against cyber or cyber-physical attacks and accidents. To help improve sector-wide safety and resiliency, the University of Plymouth (UoP) is creating a specialised maritime-cyber lab, which combines maritime technology and traditional cyber-security labs. This is in response to the lack of research and mitigation capabilities and will create a new resource capability for academia, government, and industry research into maritime cybersecurity risks and threats. These lab capabilities will also enhance existing maritime-cyber capabilities across the world, including risk assessment frameworks, cybersecurity ranges/labs, ship simulators, mariner training programmes, autonomous ships, etc. The goal of this paper is to explain the need for next generation maritime-cyber research capabilities, and demonstrate how something like the proposed Cyber-SHIP Lab (Hardware, Software, Information and Protections) will help industry, government, and academia understand and mitigate cyber threats in the maritime sector. The authors believe a next generation cyber-secure lab should host a range of real, non-simulated, maritime systems. With multiple configurations to mirror existing bridge system set-ups, the technology can be studied for individual system weakness as well as the system-of-systems vulnerabilities. Such as lab would support a range of research that cannot be achieved with simulators alone and help support the next generation of cyber-secure marine systems.
Investigation of Thermal Performance of a Ship Electrical Compartment-CFD Study
Authors: Fakhim B , Al Siyabi M , Al Ghunaimi B , Kaabi I , Hossain S
Published: December 2019

Air-conditioning system is an integrated part of the ship design and plays an important role in providing comfortable and healthy cabin environment for crews, passengers and also ensuring efficient thermal management in electrical compartments encompassing IT equipment and computer systems. Understanding the temperature and velocity distribution and the redistribution of cold air to electrical compartments could greatly improve energy efficiency, necessary for thermal management and ensuring reliable operation. To this end, optimized design of a cabin air distribution system is a necessary aspect of the cabin air conditioning system. Computational fluid dynamics (CFD) is an excellent modeling tool that can be used in the design process to simulate thermal performance of the mechanical systems. In this paper, CFD simulation is utilized to analyze the thermal behavior of a warship electrical compartment to pinpoint the cooling issues. Steady state simulations are conducted by employing a Cartesian grid and the standard turbulence k-ε model and grid dependency tests are performed with respect to cabin exhaust temperature. Temperature field and flow pattern of a compartment will be studied to cast a light on the compartment cooling issues.
Ports of the Future: Bringing Emissions in Port Visits to a Minimum by Collaboration and Digital Data Sharing
Authors: Chrysostomou A , Lind M , Bergmann M
Published: December 2019

Improving port performance is a key factor in reducing emissions from shipping. Increased utilisation of port infrastructures by ships provides incentives for shipping companies and ports to take joint actions for reducing their carbon footprint. Ports and ships are still not totally ‘in-sync’ resulting in unnecessary waiting times and/or unnecessary movements. Different initiatives associated to port call coordination/synchronization/optimization do address the potential in aligning the ships arrival and departure with the port’s capabilities to serve the ship for the reduction of waiting times and emissions. The smart port of the future needs to be based on synchronization capabilities to enable sustainable shipping. To achieve substantial environmental effects, it is, however, a need for joining forces among the different initiatives that is brought as tools to be used by maritime transport producers. In this article, numerous initiatives are identified, and an approach for bringing those together, as an enabler for gaining substantial environmental effects putting the smart port of the future at the
core.
Animal and plant-based milk and their antioxidant properties
Authors: YİĞİT Ayşe Arzu
Published: December 2019

Today, the most consumed milk is cow milk, which can be found in the market as raw, pasteurized and sterilized. In addition, goat and sheep milk are the milk types that are able to be reached easily. Nowadays,  donkey milk and camel milk are also started to be demanded, due to its similarity to breast milk and due to many protective factors. As the rate of allergy development in the newborns and the tendency of vegan nutrition increased, the production of herbal milk began to increase as an alternative to animal milk. In this review, the nutritional and protective properties of milk were explained by taking attention to the composition of different milk types.
Boğa sperması motilite parametreleri üzerine dietilheksil fitalatın etkisi
Authors: KABAKÇI Ruhi , VARIŞLI Ömer , KAYA Abdulkadir , BAŞTAN İlktan , ŞİMŞEK Seher
Published: December 2019

Dietilheksil fitalat, sert yapılı plastiklere esneklik katmak amacıyla dünya genelinde yaygın bir şeklide kullanılan, çevresel toksik bir kimyasaldır. İçerisinde bulunduğu ve gevşek bağlarla tutunduğu ürünlerden kolayca ayrılarak çevreye yayılan dietilheksil fitalat sindirim, solunum ve deri teması yollarıyla insan ve hayvanların vücuduna geçmekte ve çeşitli toksik etkilere neden olmaktadır. Bu çalışmanın amacı, dietilheksil fitalatın boğa sperması üzerine in vitro toksik etkisini, bilgisayarlı sperm analiz sistemi ile araştırmaktır. Boğalardan suni vajen ile elde edilen spermalar, fosfat tampon solüsyonu ile 50x106/ml spermatozoa olacak şekilde sulandırıldı ve dimetil sülfoksitte çözdürülen dietilheksil fitalatın 0, 1, 10, 100, 250 ve 500 µg/ml dozlarına maruz bırakılarak 1, 2, 3 ve 4 saat süreyle 37 °C su banyosu içerisinde inkübe edildi. Her inkübasyon süresinin sonunda kontrol ve deneme gruplarından alınan sperma örneklerinin motilite parametreleri analiz edildi. Yapılan değerlendirme sonucunda, dietilheksil fitalatın çalışmada kullanılan düşük dozlarında, doğrudan spermatozoa üzerine toksik etkisi tespit edilemezken, bu etkinin yüksek konsantrasyonlarda zamanla ve doza bağlı olarak ortaya çıktığı belirlendi. Özellikle 500 µg/ml dietilheksil fitalat maruziyetinin sperma hareketlilik parametrelerinden, ortalama yol hızı ve doğrusal hızı 2. saatten itibaren, total motilite ve progresif motiliteyi ise 3. saatten itibaren kontrol gruplarına göre önemli derecede azalttığı belirlendi (p<0.05). İn vitro olarak elde edilen sonuçlar dietilheksil fitalatın erkek üreme organlarında toksik birikimine bağlı olarak boğalarda spermatogenezisi etkiliye bileceğini yönündedir.
Comparative characteristics of coronary artery damage in different degree of ischemic mitral regurgitation
Authors: Krylov V. V.
Published: December 2019

Introduction.Despite an active study of the problem of ischemic mitral regurgitation, studies of its connections with the degree and localization of coronary artery lesions are contradictory.

Objective.Study the features of coronary artery lesions according to coronary angiography in patients with ischemic heart disease and ischemic mitral regurgitation and the connections between the severity of coronary artery lesions and the degree of ischemic mitral regurgitation.

Material andmethods.A retrospective analysis of the results of the examination of 86 patients with various forms of ischemic heart disease in combination with ischemic mitral regurgitation, operated in the department of cardiovascular surgery of the P.V. Mandryka Central Military Hospital. Results. 89,5 % of patients showed multifocal atherosclerotic coronary artery lesions, requiring direct myocardial revascularization; the predominant type of coronary blood supply was right (82,6 %); the average number of affected main coronary arteries was 2,2±1,1, the average total degree of coronary artery lesion was 42,3±25,1 %.

Conclusion.1. The connections between the degree of ischemic mitral regurgitation and the severity and localization of coronary artery lesions was not revealed. 2. The degree of ischemic mitral regurgitation determined primarily by the progression of ischemic remodeling of the left ventricle. 3. Coronary angiography data cannot be a criterion for determining the degree of ischemic mitral regurgitation, however, they are necessary for determining the surgical tactics of direct myocardial revascularization.
Yet another Ersatz World: The ICER Final Evidence Report for Additive Cardiovascular Therapies
Authors: Langley Paul
Published: December 2019

Previous commentaries in the Formulary Evaluation section of INNOVATIONS in Pharmacy have pointed to the lack of credibility in modeled claims for cost-effectiveness and associated recommendations for pricing by the Institute for Clinical and Economic Review (ICER). The principal objection to ICER reports has been that their modeled claims fail the standards of normal science: they are best seen as pseudoscience. The purpose of this latest commentary is to consider the recently released ICER report for Additive Cardiovascular Disease therapies. This report should not be taken seriously in its claims for cost-effectiveness and pricing in cardiovascular disease (CVD). The analytical framework applied by ICER fails to meet the standards of normal science in demarcating science from pseudoscience. Irrespective of the value judgements and recommendations of an ICER report, these lack credibility. They were never intended to be evaluable and replicable across treatment settings. The claims made are constructed, driven by   assumption, and should be put to one side by health system decision makers. In this review the focus is on to the ICER modeled estimates of utility scores in CVD, the insistence on utilizing a generic utility algorithm (the EQ-5D-3L) and the consequent quality adjusted life year (QALY) estimates. Two issues are raised that will be the subject of future commentaries: the lack of appreciation of fundamental measurement and (ii) the importance of the patient voice in benefit claims. Given the importance in the ICER methodology of QALYS, the ad hoc nature of the ordinal utilities introduced to the cardiovascular model must raise concerns over the role the ICER evidence report may play in health care decision-making. These concerns extend to the claim by ICER that, on ICER’s own affordability threshold for individual new molecular entities, the anticipated uptake of these therapies may raise questions of overall affordability. Again, we are dealing with an arbitrary construct that may adversely impact patient access.

 

Article Type: Commentary
A 72-year-old woman with periorbital swelling
Authors: West Laura J. , Petrov Andrej A. , Fajt Merritt L.
Published: December 2019

As allergists, we are frequently consulted to evaluate patients with swelling presumed to be angioedema. Patients with presumed angioedema can have multiple possible underlying triggers. We present the case of a hospitalized 72-year-old woman with a history of hypertension and metastatic
chordoma who developed marked periorbital swelling that precluded eye opening 2 days after a neurosurgical operation (chordoma resection and T10-11 hardware repair). After a detailed evaluation of her swelling, a broad differential diagnosis was made; she did not respond to high-dose antihistamines,
systemic steroids, icatibant and angiotensin-converting enzyme inhibitor cessation. Ultimately, computed tomography imaging confirmed a specific diagnosis. The differential diagnosis for swelling is complex, and this case illustrated the importance of considering alternative causes of swelling
when evaluating cases of possible angioedema.
Analisis Konstruktivisme: Prilaku Korea Utara Terhadap Denuklirisasi
Authors: Permata Inda Mustika
Published: December 2019

Tulisan ini berupaya untuk menjelaskan perubahan sikap Korea Utara terkait komitmennya dalam menghentikan program senjata nuklir. Dimulai dengan uji coba misil balistik pada tahun 2017, menuai beragam penolakan dari Cina, Korea Selatan, dan Amerika Serikat. Hingga pada April 2018, ditandatanganinya Deklarasi Pamunjom antara Korea Utara dan Korea Selatan, diiringi dengan diadakannya pertemuan Amerika Serikat dan Korea Utara pada Juni 2018 tentang denuklirisasi Korea Utara. Namun, lima bulan kemudian, IAEA melaporkan bahwa Korea Utara ternyata masih melanjutkan proram nuklirnya. Mangkirnya Korea Utara dari komitmennya disebabkan karena perbedaan identitas antara Korea utara dengan aktor lainnya di kawasan yang membentuk hubungan yang dipersepsikan sebagai rival dan kepentingan untuk mempertahankan diri.
Hacktivist pada Pergerakan Sosial Transnasional: Kampanye Anonymous melawan Jaringan Teroris Transnasional 2015-2016
Authors: Anshori Muhammad Fikry
Published: December 2019

Latar belakang artikel ini adalah aktivitas kampanye Anonymous melawan jaringan teroris transnasional. Kampanye tersebut perlu dibahas karena dilakukan oleh jaringan transnasional terhadap jaringan transnasional lainnya. Artikel ini bertujuan untuk mendeskripsikan karakteristik pergerakan sosial transnasional dalam kampanye Anonymous melawan jaringan teroris transnasional. Konsep yang digunakan dalam artikel ini adalah pergerakan sosial transnasional dari S. Tarrow yang berfokus pada empat karakteristik yaitu kesempatan politik, struktur mobilisasi, kerangka tindakan kolektif, serta repertoar perlawanan. Dari hasil penelusuran artikel ini, diketahui kampanye Anonymous melawan jaringan teroris transnasional terdiri dari enam operasi yang dilakukan selama periode 2015-2016. Operasi tersebut dilakukan oleh enam kelompok peretas sebagai bagian dari Anonymous terhadap Al-Qaeda in the Arabian Peninsula (AQAP) dan Islamic State of Iraq and Syria (ISIS) sebagai targetnya. Artikel ini menemukan Anonymous melakukan empat karakteristik pergerakan sosial transnasional dari S. Tarrow dalam enam kampanye terhadap jaringan teroris transnasional. Lebih lanjut, terdapat ciri khas tersendiri dari Anonymous sebagai aktor pergerakan sosial transnasional.