Abstract P1-10-04: Latina Interest in Genetic Breast Cancer Testing: The Significance of Having a Biological Daughter
Authors: Ramirez AG , Holden AA , San Miguel de Majors SL , Gallion KJ. 
Published: April 2011

Background. Breast cancer is a devastating disease. Identification of the BRCA1 and BRCA2 genetic mutations associated with it offer to provide an efficacious “early warning system”. However investigators question whether women are interested in knowing if they possess gene mutations, particularly minorities traditionally averse to dealing with a complex medical system. Effective means for addressing these gaps are unidentified. Here we determine the extent of interest in genetic testing among Latinas compared to Non-Hispanic White (NHW) women. Also, we identify factors associated with interest in genetic testing. Finally, we show why differences in interest in genetic testing for breast cancer exist among groups of women.

Material and Methods. We surveyed 290 women (153 Hispanic, 137 NHW) aged 26+ from the San Antonio Cancer Therapy and Research Center's catchment area. Surveys included demographic information, measures assessing breast cancer knowledge, attitudes, behaviors, and medical and family history data. Participants were assigned “high” or “moderate/low” cancer risk status according to American College of Medical Genetics Foundation guidelines. Chi-Square and Student's T-tests assessed bivariate relationships. Multivariate logistic regression identified factors associated with interest in genetic testing.

Results. 20% of women were not “Very interested” in genetic testing for the BRCA1/BRCA2 mutation. Bivariate results showed ethnicity, use of non-traditional health care sources and negative perceptions of genetic testing were associated with low interest in genetic testing among all women. A multivariate model of genetic testing interest revealed several measures significantly associated with it, including Hispanic ethnicity (OR 5.74, p&lt;.01), routine health care from any non-traditional source and negative perception of genetic testing (both OR 1.19, p&lt;.03). The Hispanic result reflected reduced interested in Genetic Testing, regardless cancer risk or having had cancer [Low-risk Latinas: 75.3% v 84.9% NHW (p&lt;.05); High-risk Latinas 75.3% v 84.9% NHW (p&lt;.05), Cochran Mantel-Haenszel (CMH) ns.], [NoHx of Cancer Latinas 75.6% v 90.2% p&lt;.04, Hx Cancer Latinas 72.0% v 82.9%, p&lt;.05, CMH ns.] Given this difference we stratified our analysis. In separate multivariate models we found that NHW women are not “very interested” in genetic testing when their perception of it is negative (OR 1.36, p&lt;.01). Latinas are significantly more likely to be interested in genetic testing when their perceived risk of breast cancer is high (OR 2.38, p&lt;.01), and importantly, when they have biological daughters (OR 7.85, p&lt;.001). 77.8% of Latinas with biological daughters (n = 98) compared to 55.6% of those without (n = 61) were “Very interested” in genetic testing for breast cancer (p&lt;.001). Conclusion: Genetic testing is generally acceptable to NHW and Hispanic women. However, Latinas are less likely to accept it than NHW.

Whereas NHW women are influenced in their decision chiefly by use of nontraditional sources of medical care, Latinas are strongly influenced by perceptions of personal risk and having biological daughters.

Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P1-10-04.