bluuebunny/crossref_metadata_2025 huggingface dataset:
Prediction of mortality in hospitalized Egyptian patients with Coronavirus disease-2019: A multicenter retrospective study
Authors: AbdelGhaffar Muhammad M. , Omran Dalia , Elgebaly Ahmed , Bahbah Eshak I. , Afify Shimaa , AlSoda Mohamed , El-Shiekh Mohamed , ElSayed Enass S. , Shaaban Soha S. , AbdelHafez Samah , Elkelany Khaled , Eltayar Ayman A. , Ali Omnia S. , Kamal Lamiaa , Heiba Ahmed M. , El Askary Ahmad , Shousha Hend Ibrahim
Published: January 2022

We aimed to assess the epidemiological, clinical, and laboratory characteristics associated with mortality among hospitalized Egyptian patients with COVID-19. A multicenter, retrospective study was conducted on all polymerase chain reaction (PCR)-confirmed COVID-19 cases admitted through the period from April to July 2020. A generalized linear model was reconstructed with covariates based on predictor’s statistical significance and clinically relevance. The odds ratio (OR) was calculated by using stepwise logistic regression modeling. A total of 3712 hospitalized patients were included; of them, 900 deaths were recorded (24.2%). Compared to survived patients, non-survived patients were more likely to be older than 60 years (65.7%), males (53.6%) diabetic (37.6%), hypertensive (37.2%), and had chronic renal insufficiency (9%). Non-survived patients were less likely to receive azithromycin (p <0.001), anticoagulants (p <0.001), and steroids (p <0.001). We found that age ≥ 60 years old (OR = 2.82, 95% CI 2.05–3.86; p <0.0001), diabetes mellitus (OR = 1.58, 95% CI 1.14–2.19; p = 0.006), hypertension (OR = 1.69, 95% CI 1.22–2.36; p = 0.002), chronic renal insufficiency (OR = 3.15, 95% CI 1.84–5.38; p <0.0001), tachycardia (OR = 1.65, 95% CI 1.22–2.23; p <0.001), hypoxemia (OR = 5.69, 95% CI 4.05–7.98; p <0.0001), GCS <13 (OR 515.2, 95% CI 148.5–1786.9; p <0.0001), the use of therapeutic dose of anticoagulation (OR = 0.4, 95% CI 0.22–0.74, p = 0.003) and azithromycin (OR = 0.16, 95% CI 0.09–0.26; p <0.0001) were independent negative predictors of mortality. In conclusion, age >60 years, comorbidities, tachycardia, hypoxemia, and altered consciousness level are independent predictors of mortality among Egyptian hospitalized patients with COVID-19. On the other hand, the use of anticoagulants and azithromycin is associated with reduced mortality.
Phenotypic characterization of primary cardiac fibroblasts from patients with HFpEF
Authors: Zhang Yuhua , Van Laer An O. , Baicu Catalin F. , Neff Lily S. , Hoffman Stanley , Katz Marc R. , Zeigler Sanford M. , Zile Michael R. , Bradshaw Amy D.
Published: January 2022

Heart failure is a leading cause of hospitalizations and mortality worldwide. Heart failure with a preserved ejection fraction (HFpEF) represents a significant clinical challenge due to the lack of available treatment modalities for patients diagnosed with HFpEF. One symptom of HFpEF is impaired diastolic function that is associated with increases in left ventricular stiffness. Increases in myocardial fibrillar collagen content is one factor contributing to increases in myocardial stiffness. Cardiac fibroblasts are the primary cell type that produce fibrillar collagen in the heart. However, relatively little is known regarding phenotypic changes in cardiac fibroblasts in HFpEF myocardium. In the current study, cardiac fibroblasts were established from left ventricular epicardial biopsies obtained from patients undergoing cardiovascular interventions and divided into three categories: Referent control, hypertension without a heart failure designation (HTN (-) HFpEF), and hypertension with heart failure (HTN (+) HFpEF). Biopsies were evaluated for cardiac myocyte cross-sectional area (CSA) and collagen volume fraction. Primary fibroblast cultures were assessed for differences in proliferation and protein expression of collagen I, Membrane Type 1-Matrix Metalloproteinase (MT1-MMP), and α smooth muscle actin (αSMA). Biopsies from HTN (-) HFpEF and HTN (+) HFpEF exhibited increases in myocyte CSA over referent control although only HTN (+) HFpEF exhibited significant increases in fibrillar collagen content. No significant changes in proliferation or αSMA was detected in HTN (-) HFpEF or HTN (+) HFpEF cultures versus referent control. Significant increases in production of collagen I was detected in HF (-) HFpEF fibroblasts, whereas significant decreases in MT1-MMP levels were measured in HTN (+) HFpEF cells. We conclude that epicardial biopsies provide a viable source for primary fibroblast cultures and that phenotypic differences are demonstrated by HTN (-) HFpEF and HTN (+) HFpEF cells versus referent control.
Clinical relevance and prognostic role of preoperative cell-free single-stranded DNA concentrations in colorectal cancer patients
Authors: Song Hyun Soo , Kang Dong Hyun , Kim Hyunjung , Ahn Tae Sung , Kim Tae Wan , Baek Moo-Jun
Published: January 2022

Purpose: Circulating cell-free single-stranded DNA (ccf-ssDNA) is extracellular DNA and it is a useful biomarker for the diagnosis of tumors and predicting the prognosis of tumors. However, the clinical usefulness of ccf-ssDNA in colorectal cancer (CRC) is not well known. Thus, the purpose of this study was to investigate the clinical usefulness of ccf-ssDNA in CRC.Methods: The study was conducted on 44 patients who had undergone surgery for CRC, and ccf-ssDNA level was measured before surgery and statistical analysis was performed on clinical factors.Results: The association between ccf-ssDNA level and clinicopathological factors was analyzed and compared, and these factors included age, sex, body mass index, diabetes mellitus, hypertension, tumor markers (carcinoembryonic antigen and carbohydrate antigen 19-9), tumor location, size, stage (TNM), recurrence, and death. The group with a ccf-ssDNA level of ≥ 7.5 ng/μL had a lower age (P = 0.010), and was associated with diabetes mellitus (P = 0.037) and lymph node metastasis (P = 0.049). Multivariate analysis of disease-free survival showed that lymph node metastasis and ccf-ssDNA level (hazard ratio, 10.011; 95% confidence interval, 2.269–44.175; P = 0.002) were independent prognostic factors for recurrence. In terms of overall survival, there were no statistically significant results except for vascular invasion.Conclusion: This study showed that ccf-ssDNA level in plasma in CRC patients was an independent prognostic factor that could predict recurrence non-invasively. In this regard, further evaluation with a prospective, large sample size study will be needed to obtain additional results.
Comparison of the quality of total mesorectal excision after robotic and laparoscopic surgery for rectal cancer: a multicenter, propensity score-matched study
Authors: Park Keehyun , Kim Sohyun , Lee Hye Won , Bae Sung Uk , Baek Seong Kyu , Jeong Woon Kyung
Published: January 2022

Purpose: This study aimed to evaluate and compare the quality of total mesorectal excision (TME) and disease-free and overall survival rates between robotic and laparoscopic surgeries for rectal cancer.Methods: From January 2015 to December 2018, 234 patients underwent curative robotic or laparoscopic surgery for rectal cancer at two centers. Ultimately, 201 patients were enrolled. To control for different demographic factors in the two groups, propensity score matching was used at a 1:1 ratio. Propensity scores were generated with the baseline characteristics, including age, sex, body mass index, American Society of Anesthesiologists score, previous abdominal surgery, tumor location, preoperative chemotherapy, and preoperative radiation. Finally, 134 patients were matched with 67 patients in the robotic surgery group and 67 patients in the laparoscopic surgery group.Results: There was no significant difference in the pathologic stages between the robotic and laparoscopic surgery groups. Distal margin involvement was only observed in the robotic surgery group (1/67, 1.5%). Circumferential resection margin involvement was not different between the robotic surgery and laparoscopic surgery groups (3/67 [4.5%] and 4/67 [6.0%], respectively, P = 1.000). The quality of TME (complete, nearly complete, and incomplete) was similar between the robotic surgery and laparoscopic surgery groups (88.0%, 6.0%, 6.0% and 79.1%, 9.0%, 11.9%, respectively, P = 0.358). The disease-free and overall survival rates were not significantly different between the groups.Conclusion: The quality of TME and disease-free and overall survival rates between the two surgeries were similar. There was no oncologic advantage of robotic surgery for rectal cancer compared to laparoscopic surgery.
Prognostic significance of splenectomy during completion total gastrectomy in patients with remnant gastric cancer: propensity score matching analysis
Authors: Back Seung Hyun , Oh Sung Eun , An Ji Yeong , Choi Min-Gew , Sohn Tae Sung , Bae Jae Moon , Lee Jun Ho
Published: January 2022

Purpose: Splenectomy for patients with remnant gastric cancer has been controversial. The purpose of this study is to identify the impact of splenectomy in the treatment of remnant gastric cancer.Methods: We retrospectively analyzed 285 patients with remnant gastric cancer who underwent completion total gastrectomy with or without splenectomy in Samsung Medical Center, between September 1996 and December 2017. We used a 1:1 propensity score matching method for the analysis. The matching factors were age, sex, and pathologic stage. After the matching process, we compared the 5-year overall survival (OS) and the disease-free survival (DFS) between patients with and without splenectomy during completion total gastrectomy.Results: The median duration of follow-up was 58.0 months (range, 0–132 months). After propensity score matching, there were no statistically significant differences between the splenectomy group (n = 77) and no splenectomy group (n = 77) in terms of clinicopathological features. The 5-year OS rate between the no splenectomy and splenectomy group were not significantly different. There was no significant difference between 5-year DFS of the matched groups. Multivariate analysis revealed that splenectomy is not a significant prognostic factor in terms of 5-year OS (no splenectomy vs. splenectomy; 61.5% vs. 60.2%, P = 0.884) or DFS (74.9% vs. 69.8%, P = 0.880).Conclusion: Splenectomy has no impact on the OS and DFS in patients with remnant gastric cancer. Splenectomy during completion total gastrectomy may not be necessary.
Short-course radiotherapy and chemotherapy for conversion surgery in patients with unresectable metastatic rectal cancer: a preliminary case series study
Authors: Jeon Youngbae , Han Kyoung-Won , Lee Seok Ho , Sym Sun Jin , Choi Seung Joon , Ha Seung Yeon , Baek Jeong-Heum
Published: January 2022

Purpose: Curative treatment is challenging in patients with locally advanced rectal cancer and unresectable metastases. The aim of this study was to evaluate the clinical outcomes of short-course radiotherapy (RT) followed by systemic chemotherapy for patients with rectal cancer with mesorectal fascia (MRF) involvement and unresectable distant metastases.Methods: The study included consecutive patients diagnosed as having metastatic mid-to-low rectal cancer treated with short-course RT followed by systemic chemotherapy for conversion radical or palliative surgery between 2014 and 2019 at Gil Medical Center. The patients had primary rectal tumors involving the MRF and unresectable distant metastases. The treatment strategies were determined in a multidisciplinary team discussion.Results: Seven patients (five men and two women) underwent short-course RT (5 × 5 Gy) and preoperative systemic chemotherapy. The median age was 68 years (range, 46–84 years), and the median distance from the anal verge to the primary tumor was 6.0 cm (range, 2.0–9.0 cm). During the median follow-up period of 29.4 months, three patients underwent conversion radical surgery with R0 resection, two underwent palliative surgery, and two could not undergo surgery. No postoperative major morbidity or mortality occurred. The patients who underwent conversion complete radical surgery showed good long-term survival outcomes, with an overall survival time of 29.4–48.8 months and progression-free survival time of 14.7–41.1 months.Conclusion: Short-course RT followed by systemic chemotherapy could provide patients with unresectable stage IV rectal cancer a chance to undergo to conversion radical surgery with good long-term survival outcomes.
Utility of sentinel lymph node biopsy in papillary thyroid microcarcinoma
Authors: Kim Hyun Yul , Kim Dong-il , Jung Chang Shin , Lee Seung Joo , Im Dong Won , Jung Youn Joo , Yeom Jeong-a , Choi Jeong Bum
Published: January 2022

Purpose: There are many studies on sentinel lymph node (SLN) biopsy in thyroid carcinoma but SLN biopsy (SLNB) in papillary thyroid carcinoma (PTC) remains open to debate. Therefore in this retrospective study, the usefulness of SLNB in thyroid carcinoma patients who had micro-PTC without cervical lymphadenopathy was assessed.Methods: SLNB was performed in 114 patients who were diagnosed with micro-PTC in a single lobe without palpable or ultrasound-detected lymph node at the tertiary center between January 2012 and December 2013. After SLNB, all patients underwent total thyroidectomy and central neck dissection or thyroid lobectomy and central neck dissection of the single side.Results: SLNs were identified in 112 of 114 patients with 41 positive SLNs and 71 negative SLNs on intraoperative frozen sections. However, eight negative patients were found to be positive in the final pathology. Sentinel node identification rate and false negative value of SLNB were 98.2% and 11.3%, respectively. In the univariate analysis, higher lymph node metastasis was detected in men than in women. Higher detection number of SLN showed higher probability of lymph node metastasis.Conclusion: SLNB may be helpful in papillary thyroid cancer, especially in male patients. Also, it is useful for the staging of nodal status and clearance of persistent disease.
Experience of serious intestinal hemorrhage and perforation in small bowel lymphoma: a case report
Authors: Kim Seo Ree , Chun Sang Hoon , Jin Jong Youl , Gweon Tae-Geun , Lee Hayemin , Jin Min-Sun , Lee Guk Jin
Published: January 2022

There have been several reports of complications of small bowel lymphoma, such as bleeding, obstruction, and perforation, often require emergency surgery. It is hardly showed complications of bleeding and wound dehiscence for diffuse large B cell lymphoma with distal ileum involvement, which needed urgent surgery and medical management. A 65-year-old man with diffuse large B-cell lymphoma with distal ileum involvement experienced both intestinal bleeding and perforation during the course of treatment. As the patient was diagnosed with stage III disease, resection before chemotherapy was not considered due to the resulting delay in chemotherapy, which necessitated sufficient tissue healing. Chemotherapy is important when treating small bowel lymphoma, complications such as bleeding and perforation should always be considered for the treatment of small bowel lymphoma, and surgery is necessary in this situation. After surgery of the small bowel, subsequent chemotherapy could cause wound dehiscence and perforation; therefore, adequate recovery time should be given before chemotherapy.
Effect of Particle Size on Physico-Chemical and Antioxidant Activity of
Insoluble Dietary Fiber Powder from Corncob (Zea mays L.)
Authors: Suryanto Edi , Taroreh Mercy R.I.
Published: January 2022

Effects of particles size of dietary fiber powder on the physico-chemical properties and antioxidant
activity of corncob were investigated. Corncob was grounded in a regularly mill and grinding
characteristics and the particles size were evaluated by particle size analyzer (PSA) using laser diffraction
method and Fourier transform infrared (FTIR). The results showed that the insoluble dietary fiber
(IDF) powder from corncob had the highest crude fiber content (32.31%) and carbohydrates (55.07%).
Spectral analysis shows that the IDF matrix structure does not change after grinding and has three
characteristics of absorption spectra at 3433-3425 cm-1 (O-H); 2920 cm-1 (C-H) and 1635 cm-1 (aromatic)
in presence of the special structures of polysaccharide and lignin compounds. Particle size analyzer
(PSA) results showed that the size of IDF 200 mesh and 80 mesh powder were 63.13 and 260.89 μm,
respectively. The insoluble dietary fiber (IDF) significantly shows a decrease in dietary fiber content
in line with the reduction in particle size. The IDF powder with a particle size of 63.13 μm showed that
highest total phenolic content accompanied with the best antioxidant activity through all antioxidant
assays (p < 0.05). This study concluded that the IDF micro-powder particle size exerted influence on
physico-chemical properties, dietary fiber, total phenolic and antioxidant activity.
Structural and Optical Properties of Chemically Deposited Metal
Chalcogenide Thin Film CrS and its Photovoltaic Application
Authors: Chandrasekar J. , Manikandan Durgachalam
Published: January 2022

In this work, chromium sulfide (CrS) thin films were grown on the acetic acid substrates by chemical
bath deposition to prepare non-toxic photovoltaic devices. The combined single-source precursor
approach has been developed for the deposition method using
tris(diethyldithiocarbamato)chromium(III) for the deposition of CrS thin films grown at bath
temperatures of 30, 60 and 90 ºC and at a constant deposition time of 30-120 min. The sufrace
mophology of the prepared films have been analyzed by SEM and HR-TEM techniques. The study of
the films indicate the distributed roughness and nano bundled hexagonal structures. The energy
dispersive X-ray (EDX) spectroscopy analysis conformed the presence of Cr and S. The polycrystalline
behaviour of the films was studied by an XRD study which revealed the mixed phases with a predicted
crystallite size of 20 nm. The optical measurements showed films had a maximum transmittance of
90% in the visible region and the evaluated energy band varied in the range of 2.2-2.378 eV with the
change of bath temperatures. This suggests that CrS thin film prepared at 90 ºC has enhanced crystalline
superiority. According to photoluminescence (PL) analysis, the green emission can be attributed to
the presence of several deep trap states or defects in the CrS structure. Moreover, natural dye sensitized
solar cells (DSSCs) in CrS thin film prepared at 90 ºC, Jsc (28.0 mA/cm2) produced a larger voltage in
the short circuit as compared to synthetic dye sensitized solar cells (DSSCs) using CrS thin film Jsc
(22.5 mA/cm2).
Effects of Physico-Chemical Properties of the Blended Diesel and Waste Cooking Oil Biodiesel
Authors: Viraj Miyuranga K.A. , Arachchige Udara S.P.R. , Thilakarathne Danushka , Jayasinghe Randika A. , Weerasekara Nuwan A.
Published: January 2022

Biodiesel is a renewable fuel with similar chemical and physical properties to diesel. The study used
waste cooking oil to make biodiesel because reusing waste cooking oil harms human health by raising
FFA levels above the norm. Transesterification was performed at 60 °C using a 1:5 methanol to waste
cooking oil volume ratio, 30 min reaction time, 600 rpm stirring speed and 1% wt. KOH was employed
as a homogenous base catalyst. Biodiesel samples of B0, B2, B5, B20, B40 and B100 were processed
at 25 ºC in combination with petrodiesel. Samples were tested for density, kinetic viscosity, flash
point, acid value and pH. The fuel economy and flue gas analysis were performed using three-wheeler
diesel. The amount of waste cooking oil biodiesel increases the density, kinematic viscosity, flash
point, acid value and pH of the sample. In blended diesel, the amount of biodiesel also lowered CO2,
CO, NO, NOx, hydrocarbon (HC) and SO2 emissions.
Synthesis and Deblocking Investigations of Phenol Blocked Aliphatic Isocyanates and
Their Application in the Development of Epoxy-Polyurethane Films
Authors: Rajendran Karthi , Srinivasan Vennila , Govindarajan Sankar
Published: January 2022

Phenol blocked hexamethylenediisocyanate adducts and polyisocyanates were synthesized and their
structure was validated by FTIR, 1H & 13C NMR spectroscopy, TGA, DSC and CO2 evolution techniques
were used to evaluate the deblocking temperature of blocked isocyanates. Gel time studies of blocked
isocyanates with terathane polyol and solubility study of blocked isocyanates with different polyols
were conducted to demonstrate the structure-property correlation. Epoxy-polyurethane films were
produced utilizing the blocked isocyanates reported in this work with epoxy resin and their structure
was verified by ATR Spectroscopy. TGA, DSC, shore A hardness, tensile strength and flexural strength
analysis were used to investigate the thermal and mechanical characteristics of these films. The findings
of deblocking temperature and gel time revealed that unsubstituted phenol blocked isocyanates and
polyisocyanates deblock at lower temperatures and cure for a shorter time period than substituted
phenol blocked isocyanates. Thermal and mechanical characteristics of epoxy-polyurethane films based
on blocked polyisocyanates are satisfactory.
Antimicrobial Activity of Synthesized Multi-Metallic
Nanoparticles using Traditional Indian Siddha Method
Authors: Balakrishnan Kaviarasu , Arumugam Sivabalan , Ezhumalai Dhineshkumar , Karthikeyan Ramasamy , Magesan G.N.
Published: January 2022

In present work, multi-metallic nanoparticles were synthesized by chemical method in a controlled
environment by using silver, lead, mercury, egg shell powder (contains 1% calcium phosphate, 1%
magnesium carbonate, 94% calcium carbonate and 4% organic matter), potassium nitrate, potassium
alum and extracts of citrus lemon by following the process defined in Traditional Indian Medicine,
Siddha System of Medicine. The morphology, compositions and structure of the product were
characterized by powder X-ray diffraction (PXRD), Fourier transform infrared (FTIR), scanning electron
microscopy (SEM), energy dispersive X-ray (EDX) and transmission electron microscopy (TEM)
techniques. Highly uniform spherical multi-metallic nanoparticle was subjected for the antibacterial
activities. The particles were agglomerated as observed by SEM micrographs. The particles were
homogeneous, spherical in shape and loosely agglomerated as seen by TEM pictures. The antibacterial
activity of the synthesized multi-metallic nanoparticles against B. cereus, S. aureus, E. coli and P.
aeuroginosa was demonstrated using the zone of inhibition technique. The synthesized multi-metallic
nanoparticle can find plausible biological applications.
Gestão do cuidado e matriciamento na atenção primária à saúde: um relato de experiência
Authors: Figueiredo Minéia da Costa , Paula Fabiana Lopes de
Published: January 2022

Este artigo irá abordar a vivência em uma unidade de Estratégia Saúde da Família (ESF) no município de Canto do Buriti-PI sobre os aspectos relacionados ao processo de matriciamento e a gestão do cuidado. A descrição será feita a partir da análise da gestão do cuidado e articulações com o Núcleo de Apoio à Saúde da Família (NASF) e suas ações de apoio matricial desenvolvidas na unidade. O NASF tem fundamental importância na resolução de casos mais complexos e na efetivação de cuidado integral, bem como para a assistência humanizada aos usuários na Atenção Primária à Saúde. O relato traz como contribuição a análise do processo de trabalho entre eSF e NASF, com uma visão que traz subsídios para a reflexão; tendo a intenção de cooperar para o aperfeiçoamento, progresso das ações na APS e a concretização das políticas públicas.
Palavras-chave: Atenção Primária à Saúde; Estratégia Saúde da Família; Equipe de Assistência ao Paciente; Integralidade em Saúde; Sistema Único de Saúde.
 
Abstract
This article will address the experience in a Family Health Strategy (ESF) unit in the city of Canto do Buriti-PI on aspects related to the matrix support process and care management. The description will be made from the analysis of care management and articulations with the Family Health Support Center (NASF) and its matrix support actions developed in the unit. The NASF is of fundamental importance in solving more complex cases and in providing comprehensive care, as well as in providing humanized assistance to users in Primary Health Care. The report contributes to the analysis of the work process between eSF and NASF, with a a vision that supports reflection; with the intention of cooperating for the improvement, progress of actions in the PHC and the implementation of public policies.
Keywords: Primary Health Care; Family Health Strategy; Patient Care Team; Integrality in Health; Unified Health System.
O Glide Path na Endodontia Contemporânea: Revisão de Literatura / The Glide Path in Contemporary Endodontics: Literature Review
Authors: Oliveira Martins Danielle Fernandes , De Farias Maria Clara Santos , Da Silva Luiz Roberto Mendes
Published: January 2022

Por meio deste estudo é possível analisar que a instrumentação dos canais radiculares após o uso do Glide Path traz inúmeros benefícios, incluindo o melhor deslizamento dos instrumentos, redução do número de fraturas e menor intercorrências intrarradiculares. Além disso, essa preparação inicial do canal radicular com o uso do Glide Path realiza uma desobstrução, criando um “caminho” livre para o melhor deslize dos instrumentos no canal radicular. Os instrumentos possuem características e particularidades que levam ao mesmo objetivo de preparar o conduto para uma segura instrumentação, destaca-se aqui o WaveOne Gold, R-Pilot e o PathFile. É uma técnica que vem sendo difundida e utilizada na endodontia contemporânea com o intuito de realizar um procedimento eficaz.---Abstract: Analyze the use of instruments to prepare the Glide Path and understand how this endodontic instrument brought advantages in instrumentation techniques. This is a literature review with selected articles from the last 10 years, in order to achieve the objectives proposed by the theme. Articles in English and Portuguese were used, with all information pertinent to the topic extracted. Through this study, it is possible to analyze that the instrumentation of root canals after the use of the Glide Path brings numerous benefits, including better sliding of the instruments, reduction in the number of fractures and less intra-radicular complications. In addition, this initial preparation of the root canal using the Glide Path performs clearance, creating a clear “path” for the best glide of the instruments in the root canal. The instruments have characteristics and particularities that lead to the same objective of preparing the conduit for safe instrumentation, the Wave One Gold, R-Pilot and PathFile stand out here. It is a technique that has been disseminated and used in contemporary endodontics with the aim of performing an effective procedure. Through this bibliographical study, it is possible to consider that the use of the Glide Path favors the preparation of the root canal and proves to be effective and safe when used before instrumentation, thus, with the creation of a more favorable environment for instrumentation, the chances of success in endodontic treatment.
Condução de manejo de comportamento associadas a terapias integrativas em pacientes odontopediátricos: Revisão de literatura / Conducting association treatment associated with integrative therapies in pediatric dental patients: Literature review
Authors: Souto Thainá Cardoso , Souza Isabela Nunes , Carvalho Milena Tavares de
Published: January 2022

O objetivo deste artigo foi dispor aos profissionais conhecimento e embasamento sobre o uso de terapias integrativas em controle de comportamento em pacientes odontopediátricos. Trata-se de uma revisão de literatura de cunho narrativo e caráter exploratório que será fundamentado na coleta de artigos científicos nas principais bases de dados: Scielo, Lilacs, PubMed e Google Acadêmico. Buscou-se contribuir cientificamente com o conhecimento a fim de empregar corretamente a condução de manejo com terapias integrativas mais adequadas a cada situação no atendimento clínico odontopediátrico. Conclui-se que o  conhecimento técnico e científico do manejo do comportamento infantil e das terapias integrativas no atendimento odontológico infantil é fundamental em busca de desenvolvimento físico e emocional de modo satisfatório.  ---The aim of this article was to provide professionals with knowledge and foundation on the use of integrative therapies in behavior control in pediatric dental patients. This is a literature review of a narrative and exploratory nature that will be based on the collection of scientific articles in the main databases: Scielo, Lilacs, PubMed and Academic Google. We sought to contribute scientifically with knowledge in order to correctly employ the management of the most appropriate integrative therapies for each situation in pediatric clinical care. It is concluded that technical and scientific knowledge of the management of child behavior and integrative therapies in child dental care is essential in the search for satisfactory physical and emotional development.
A Retenção de Talentos e o Novo Normal de Recursos Humanos / Talent Retention and the New Normal of Human Resources
Authors: Nunes Ana Lúcia De Paula Ferreira , Martins Gabriella Granel , Mendonça Jéssica Da Mata
Published: January 2022

O presente estudo teve como propósito fazer uma investigação sobre a Retenção de Talentos nas Organizações e como objetivo, diagnosticar como é feito o processo de Retenção de Talentos nas Organizações atualmente, buscando delinear os fatores preponderantes para a retenção, com o propósito de atender às novas exigências para tal e continuidade de resultados almejados, diante do cenário desafiador de pandemia vivenciado nos últimos dois anos. Foram realizadas pesquisas exploratórias, por meio de uma revisão bibliográfica embasada nos conteúdos de autores da área, a fim de apresentar conceitos aprofundados sobre o tema em questão. Observou-se que embora, a retenção de talentos é um dos desafios do RH perante o “novo normal”, as ferramentas relacionadas à retenção de talentos das empresas evoluíram consideravelmente diante das circunstâncias, cenários atípicos e modificações no ambiente organizacional. O artigo resultou no melhor entendimento sobre o progresso organizacional e a transformação na visão dos talentos, os quais foram diretamente influenciados pela Covid-19. Por isso, almeja-se que este estudo contribua para o compartilhamento de conhecimentos interligados a essa nova realidade no mercado de trabalho durante e no pós-pandemia.---The purpose of this study was to investigate the Talent Retention in Organizations and to diagnose how the Talent Retention process is currently carried out in Organizations, seeking to outline the predominant factors for retention, to meet the new requirements for this and continuity of desired results, given the challenging pandemic scenario experienced in the last two years. Exploratory research was carried out, through a literature review based on the contents of authors in the area, to present in-depth concepts on the topic in question. It was observed that, although talent retention is one of the HR challenges facing the “new normal”, the tools related to talent retention in companies have evolved considerably considering circumstances, unusual scenarios, and changes in the organizational environment. The article resulted in a better understanding of organizational progress and the transformation in the vision of talent, which were directly influenced by Covid-19. Therefore, it is hoped that this study will contribute to the sharing of knowledge linked to this new reality in the labor market during and after the pandemic.
Utilization of Dietitians in the Management of Irritable Bowel Syndrome by Members of the American College of Gastroenterology
Authors: Scarlata Kate , Eswaran Shanti , Baker Jason R. , Chey William D.
Published: January 2022

INTRODUCTION:

The aim of this study was to identify benefits and barriers to using a gastroenterology (GI) dietitian for irritable bowel syndrome (IBS) care.

METHODS:

A 25-question survey was electronically distributed to the members of the American College of Gastroenterology. Information pertaining to demographics, barriers, and values to using a GI dietitian for IBS patient care was collected.

RESULTS:

Two hundred seventy-nine survey responses were collected. Although 56% of the GI providers feel they are trained to provide nutrition education, almost half (46%) sometimes, rarely, or never provided information to aid menu planning, label reading, or grocery shopping, and 77% spent ≤10 minutes for nutrition counseling. Of those with access to a local dietitian, 91% strongly agreed or agreed that having access to a GI dietitian would help them manage their IBS patient care more effectively, but 42% lack access to a local GI dietitian.

DISCUSSION:

Our survey identified gaps in nutrition-based interventions for IBS care.
Long-term β-cells autoimmune destruction markers persistence and residual C-peptide secretion in type 1 diabetes mellitus
Authors: Ragimov M. R. , Derevyanko O. S. , Malysheva N. M. , Zuraeva Z. T. , Nikankina L. V. , Nikonova T. V.
Published: January 2022

Backgraund: It believed that autoimmune process maintained only during the first 5 years of diabetes mellitus type 1 (T1D). Recently scientists discovered the high levels of islet autoantibodies (Ab) in long-standing T1D and some of these patients had residual insulin secretion, determined by the level of C-peptide. According to various sources, the prevalence of such observations ranges from 12 to 48%.

Aims: The aim of our study was to assess the duration of autoimmune β-cells destruction markers persistence and residual fasting C-peptide secretion in the long-standing T1D, as well as to determine the possible causes and patterns of these processes.

Materials and methods: In the study included 237 patients (91 men, 146 women) with T1D. Patients divided in 4 groups, according to disease duration: а — up to 1 year, n=69 (29%); b — 1–5 years, 52 (22%); c — 5–10 years, 57 (24%); d — more than 10 years, 59 (25%). Ab to glutamic acid decarboxylase (GADA), tyrosine phosphatase-like IA-2 (IA2) and zinc T8 (ZnT8A) were detected by Enzyme Immunoassay. Also detected C-peptide levels and retrospectively HbA1с.

Results: Antibodies to antigens of β-cell components were detected in 26 (37%) patients in group A, in 17 patients (33%) in group B, in 15 (29%) in group C and in 14 (23%) — G.

In the control group (n = 19), an increased level of antibodies was not revealed. Fasting C-peptide levels were as follows: in group «A» — 0.86 ng / ml [0.53; 1.4], «B» — 0.65 ng / ml [0.27; 0.98], « B «- 0.19 ng / ml [0.17; 0.33],» D «- 0.01 ng / ml [0.01; 0.01]. However, in 13 (22%) patients in group D, fasting C-peptide levels were more than 0.09 ng / ml.

Conclusion: The data obtained indicate a long-term persistence of markers of the autoimmune process in patients with T1DM. In groups with a long (more than 5 years) course of T1DM, levels of fasting C-peptide more than 30 pmol/L (0.09 ng / ml or 0.03 nmol / L) were noted in 39 (33.6%) cases.
Physical Activity Profile and Risk of Type 2 Diabetes Mellitus in Udupi (India) Population
Authors: Ladha N. , Maiya A. , Prabhu N. , Kumar A.S. , G S. , Kalkura P.
Published: January 2022

Background: Throught the world, More than 75% of adults with type 2 diabetes mellitus (T2DM) live in low and middle-income countries. Amongst which 69.2 million of these adults live in India. Its been shown that, as level of physical activity increases, risk of developing T2DM decreases by 15-60%. Many studies are conducted to find the risk of development of T2DM in the coastal areas of Karnataka. However, the screening of people living in Udupi was not carried out.

Aim: To find out the risk for the development of T2DM using IDRS and physical activity levels in Udupi population.

Material and Methods: In the current study, we included participants who were asymptomatic and undiagnosed to be having T2DM. The participants age ranged between 30–65 yrs. Participants with the history of any neurological conditions and women who were pregnant at the time of screening were excluded. We recorded random blood glucose levels of the participants following which the risk score was obtained using the Indian Diabetes Risk Score (IDRS) and the participants were classified as high risk (score ≥60), moderate risk score (30–50) and low risk (score <30). The level of physical ­activity was measured using Global Physical Activity Questionnaire.

Results: The study included 23,960 participants from Udupi district, Karnataka. Based on IDRS risk stratification, 1.5%, 17.9%, 27.5% of the participants with the age ange of 30–35 yrs, 36–50 yrs and more than 50 yrs respectively had higher risk of developing T2DM. According to GPAQ score 14% of the participants were following sedentary lifestyle, 27.6% of the were minimally active, 53.7% were very active, and 4.6% were highly active.

Conclusion: From the current study we conclude that 46.9% of participants had a higher risk of developing T2DM in future who are living in Udupi district.
Clinical, hormonal and molecular-genetic characteristics of monogenic diabetes mellitus associated with the mutations in the INS gene
Authors: Tikhonovich Yu. V. , Petryaykina E. E. , Timofeev A. V. , Zubkova N. A. , Kolodkina A. A. , Sorkina E. L. , Vasiliev E. V. , Petrov V. M. , Andrianova E. A. , Zilberman L. I. , Svetlova G. N. , Кalinin A. L. , Rubtsov P. M. , Кiselev S. L. , Panova A. V. , Shreder E. V. , Krasnova T. S. , Kulieva B. P. , Gariaeva I. V. , Rybkina I. G. , Malievskiy O. A. , Tyulpakov A. N.
Published: January 2022

Background:Currently more than 50 mutations of the INS gene are known to affect the various stages of insulin biosynthesis in the beta cells of the pancreas. However only individual cases of diabetes mellitus (DM) associated with heterozygous mutations in the coding region of the INS gene were reported in Russian Federation. We report a group of patients with a clinical manifestation of DM caused by mutations in both coding and non-coding regions of the INS gene. The patients with a mutation in the intron of the INS gene are reported for the first time in Russian Federation

Materials and methods: 60 patients with an isolated course of neonatal DM (NDM), 52 patients with a manifestation of DM at the age of 7–12 months and the absence of the main autoimmune markers of type 1 DM, 650 patients with the MODY phenotype were included in the study. NGS technology was used for molecular genetic research. Author’s panel of primers (Custom DNA Panel) was used for multiplex PCR and sequencing using Ion Ampliseq™ technology. The author’s panel “­Diabetes Mellitus” included 28 genes (13 candidate genes of MODY and other genes associated with DM).

Results:13 heterozygous mutations were identified in 16 probands and 9 relatives. The majority of mutations were detected in patients with PNDM (18.75%) and in patients with an onset of DM at the age of 7–12 months (9.6%). Mutations in the INS gene were detected in 2 patients (0.3%) in the group with the MODY phenotype. Mutations in the INS gene were not detected in patients with transient NDM (TNDM). Analysis of clinical data in patients with PND and onset of diabetes at the age of 7–12 months did not show significant differences in the course of the disease. The clinical characteristics of the cases of MODY10 and diabetes caused by a mutation in the intron of the INS gene are reported in details.

Conclusion:The role of INS gene mutations in NDM, MODY, and DM with an onset at the age of 7–12 months was analyzed in a large group of patients. The clinical characteristics of DM due to a mutation in the intron of the INS gene are reported for the first time in the Russian Federation.
Quality of ejaculate of male patients with type 2 diabetes mellitus (DM), vaccinated with GamCovidVac (Sputnik V)
Authors: Esaulenko D. I. , Rozhivanov R. R. , Shishkina V. V.
Published: January 2022

Background: New coronavirus infection (Covid-19) in patients with diabetes type 2 mellitus (DM) often has severe clinical course and manifestation. This comorbidity is a reasonable indication for vaccination. Male patients are often concerned about the vaccination impact on their fertility, so the current research of this issue seems to be essential and relevant.

Aims: To evaluate the quality of ejaculate in type 2 diabetes mellitus (DM) patients, vaccinated by GamCovidVac (Sputnik V).

Materials and Methods: The pilot observational prospective study included 30 males with type 2 diabetes mellitus (DM). The study continued from February 2021 till June 2021. The research design involved medical history analysis, glycated hemoglobin (HbA1c) tests, total testosterone level in blood measurement, semen analysis (sperm count test). Group comparison was performed by Wilcoxon Signed Ranks Test. The differences were considered statistically significant at p<0.05.

Results: After vaccination 19 patients (63%) demonstrated a temperature rise which lasted for 2 days; 26 patients (87%) complained of tenderness in the injections site which lasted up to 5 days. Though a few patients reported general somatic side effects after the vaccination, there have been no statistically significant deviations in sperm count, viability, function and morphology. The levels of glycated hemoglobin and total testosterone remained unchanged.

Conclusion: The study revealed no negative impact of GamCovidVac on ejaculate quality, total testosterone level and compensation of carbohydrate metabolism.
Remote monitoring of adolescents with type 1 diabetes mellitus using a mobile application
Authors: Laptev D. N. , Eremina I. A. , Karpushkina A. V. , Petryaykina E. E. , Bezlepkina O. B. , Peterkova V. A.
Published: January 2022

Background: The prevalence of type 1 diabetes mellitus (T1DM) in childhood is increasing every year. Adolescence is the most challenging age for achieving optimal metabolic control of T1DM. Telemedicine has already been shown to be ­effective in children with the condition, but there are not enough studies in adolescents. The use of mobile apps may be associated with better glycemic control in patients with type 1 diabetes.

Aims: To assess the effectiveness and safety of a model of medical care for adolescents with type 1 diabetes using remote counseling and a mobile application.

Materials and methods: Were included adolescents aged ≥14 and 18 years with a T1DM duration> 3 months, a glycated hemoglobin level (HbA1c)> 7%. The duration of the study was 26 weeks. There were 3 face-to-face and at least 4 remote visits using a mobile application. All patients underwent standard examination and anthropometry, study of HbA1c, registration and analysis of indicators, assessment and correction of the treatment. The quality of life of adolescents was assessed at baseline and at the end of the study. Adolescents and physicians were interviewed about program evaluation.

Results: 56 patients were included, 7 adolescents withdrew. HbA1c significantly decreased by the 12th week of the study (–0.3%; p = 0.005), by the end of the study the change in HbA1c was –0.5% (p <0.001). There was an increase in the percentage of glucose measurements in the target range (+5.3 pp; p = 0.016) and a decrease in blood glucose variability (-3.1 pp; p =  0.015). There was a significant improvement in both the total assessment of the quality of life by patients (+2.9 points; p = 0.008) and individual components of its indicators: attitude to diabetes (+3.0 points; p = 0.049), attitude to treatment (+4.6 points; p = 0.010) and communication with others (+4.5 points; p = 0.015). The majority of doctors and patients assessed their participation in the study positively. The incidence of adverse events did not change significantly during the study from baseline.

Conclusion: Remote counseling using a mobile app is a safe and effective approach for adolescents with T1DM in terms of glycemic control and quality of life, and provides convenience and speed of interaction.
Endothelial function status in hypogonadal men
Authors: Khripun I. A. , Vorobyev S. V.
Published: January 2022

Background: Type 2 diabetes mellitus (T2DM) and hypogonadism are mutually aggravating diseases associated with the development and progression of cardiovascular pathology. The status of endothelial function in men with T2DM and hypogonadism hasn’t been studied.

Aims: To assess the effect of hypogonadism on endothelial function in men with T2DM.

Materials and methods: Patients underwent clinical studies, assessment of carbohydrate and lipid metabolism, the content of sex hormones (total testosterone (T), sex hormones binding globulin, free T, luteinizing hormone) and markers of endothelial function (nitric oxide (NO), endothelial nitric oxide synthase type 3 (eNOS3), endothelin, adhesion molecules ICAM-1, VCAM-1, p- and e-selectins, cadherin), ultrasound examinations of endothelium-dependent vasodilation (EDVD) of the brachial artery (BA) and carotid arteries with an assessment of the thickness of intima-media complex (TIM) were performed.

Results: The study included 276 men with T2DM (age 54.0[49;60] years), who were divided into 2 groups: 1–124 patients with hypogonadism; 2–152 eugonadal patients. Reduction of the endothelial vasomotor function was detected in 32.4% of patients in the 2st group and in 55.3% of the 1nd group (χ2=6.1; p=0.01), which was associated with a decrease in EDVD by 29.8 % (p<0.001) and an increase in the time of development of maximal BA vasodilation by 30 seconds in patients with hypogonadism (p<0.001). The TIM of the carotid arteries was 10% more in group 1 compared with group 2 (p=0.03). The ­level of NO in the 1st group was reduced by 1.6 times (p=0.001), eNOS3–by 1.5 times (p=0.038) compared with the 2nd group. The concentrations of adhesion molecules were higher in group 1 compared to group 2: VCAM-1 by 32.5% (p<0.001), ICAM-1 by 43.5% (p<0.001), p-selectin–by 19.3% (p=0.004), cadherin–6 times (p<0.001).

Conclusion: Hypogonadism in men with T2DM is associated with the development of endothelial dysfunction, which manifests in a weakening of the EDVD and a slowdown in its development, as well as disturbances of the secretory activity of endothelium–a decrease in NO synthesis and activation of the adhesion molecules expression, which can be regarded as an universal pathogenetic mechanism of the development of cardiovascular diseases in combination of T deficiency and T2DM.