bluuebunny/crossref_metadata_2025 huggingface dataset:
El pensamiento de santo Tomás de Aquino en Bogotá entre el «Olimpo Radical» y la «Hegemonía Conservadora» (1863-1930)
Authors: Ferrari Francesco
Published: December 2024

El presente artículo tiene el objetivo de reconstruir el impacto del pensamiento de santo Tomás de Aquino en el desarrollo cultural de Bogotá entre 1863 y 1930. El estudio se realizó a través del análisis de las principales publicaciones sobre Tomás de Aquino y su filosofía, impresas en Bogotá durante el periodo considerado y que se buscaron en el catálogo de la Biblioteca Nacional de Colombia. Entre estas destacan las obras de monseñor Rafael María Carrasquilla y los artículos de la Revista del Colegio Mayor de Nuestra Señora del Rosario. La fuente primaria se contrastó con la bibliografía sobre el tema, que va desde los clásicos ensayos de Jaramillo Uribe hasta las más recientes publicaciones. El artículo se divide en tres partes. En la primera se reconstruye el tomismo bogotano durante el Olimpo Radical (1863-1886), en la segunda se estudia la filosofía del Aquinate a lo largo de la Regeneración (1886- 1902) y en la tercera se analiza el neotomismo en el marco la Hegemonía Conservadora (1902-1930). Este trabajo demuestra la importancia del neotomismo en el desarrollo cultural de Bogotá y subraya las características comunes a los pensadores capitalinos inspirados en la doctrina del Aquinate, por ejemplo, que el pensamiento del Doctor Angélico brindaba respuestas a los interrogantes de la sociedad santafereña entre los siglos XIX y XX.
Del multiculturalismo a la comunicación intercultural. Análisis crítico y propuestas a partir de las aportaciones de F. D’Agostino
Authors: Fernández-Ruiz-Gálvez Encarnación
Published: December 2024

El trabajo parte de la distinción entre la multi­culturalidad como hecho, consistente en la coexistencia en un mismo ámbito de diferentes formas de vida culturales, y el multiculturalismo como uno de los modelos posibles de tratamiento de la diversidad cultural, esto es, como una pro­puesta normativa. Desde estas premisas, el artículo analiza las relaciones entre relativismo y multiculturalismo y profundiza en las objeciones que pueden formularse frente a ambos, re­feridas tanto a sus fundamentos teóricos, como a sus conse­cuencias prácticas. En la última parte del trabajo, con apoyo en el pensamiento de D’Agostino, se propone como modelo más adecuado para la gestión de la diversidad cultural el de la interculturalidad que descansaría sobre dos pilares: (i) el reconocimiento de una dimensión antropológica/universal de los valores que subyace a la pluralidad de manifestaciones culturales de los mismos; y (ii) la primacía de las personas –sujetos protagonistas de la comunicación intercultural– y de sus derechos sobre las comunidades de pertenencia.
La renovada edad de los deberes: una aproximación desde la filosofía del derecho
Authors: Anzalone Angelo
Published: December 2024

El discurso sobre los deberes en la filosofía del derecho constituye el eje principal de este trabajo. Vere­mos cómo algunos ilustres pensadores se han ocupado de una interesante temática –la de los deberes– que vuelve al debate iusfilosófico con fuerza y vigor. En la parte fi­nal del trabajo nos detendremos particularmente en la aportación de Francesco D’Agostino, con el objetivo de comprender la importancia que este autor atribuye a las dinámicas de fraternidad y solidaridad –en el derecho y para el derecho–.
Dalla bioetica alla biogiuridica di Francesco D’Agostino
Authors: Palazzani Laura
Published: December 2024

L’articolo si concentra sulla visione filosofica della bioetica e del biodiritto di Francesco D’Agostino. Nel primo paragrafo viene evidenziata la sua particolare visione bioetica, che può essere descritta come cattolica e laica allo stesso tempo. Nel secondo, viene ricostruita la prospettiva teorica della sua bioetica. Nel terzo, l’attenzio­ne si concentra sulla “vita” come oggetto della bioetica, a partire dalla distinzione terminologica tra zoé e bios. Nel quarto e nel quinto si discute la posizione di D’Agostino nei confronti delle nuove tecnologie, con particolare attenzio­ne a quelle di inizio e fine vita. Nel sesto, si esamina il con­cetto di fragilità nella sua filosofia, che viene contrapposto come valore rispetto al perfezionismo del potenziamento tecnologico. Infine, nell’ultimo paragrafo il tema centrale è l’etica della cura. L’obiettivo dell’articolo è quindi quello di mostrare la rilevanza e l’innovatività del contributo di Francesco D’Agostino alla bioetica e al biodiritto.
De la naturaleza a la biojurídica
Authors: Sartea Claudio
Published: December 2024

El artículo propone una recuperación de la filosofía de la naturaleza en un sentido metafísico como base para una fundamentación de la biojurídica. El autor de referencia es Francesco D’Agostino, iusfilósofo y bioético italiano recientemente fallecido: su herencia cultural se pone aquí en diálogo con el pensamiento de otros maestros del pensamiento contemporáneo como Sergio Cotta y Robert Spaemann. La tesis esencial que se desprende del trabajo es que sólo una concepción metafísicamente abierta de la naturaleza humana es capaz de dotar a la reflexión biojurídica de una base sólida para la correcta formulación y solución de los problemas y desafíos que nos plantean las actuales biotecnologías manipuladoras, evitando, tanto la fugas hacia adelante del posthumanismo, como la rendición teórica a la praxis tecnomórfica.
Quantitative risk assessment: methodology and application in an automaker body-in-white production line project
Authors: De França Poggi Thiago , Oliveira Duarte Heitor , Santos Campos de Siqueira Paulo Gabriel , Dayvson Marques Ferreira Adriano
Published: December 2024

Purpose: this research aims to introduce a novel methodology, termed Quantitative Risk Assessment for body-in-white projects, to forecast the expected project completion time and total project cost. This methodology is demonstrated through application to a real project within an automotive manufacturer in Brazil.
Theoretical framework: the study employs established risk analysis methods (e.g., program evaluation and review technique, preliminary hazard analysis, Gaussian curve, Monte Carlo simulation) alongside project management tools for problem characterization (e.g., project requirements, assumptions, work breakdown structure).
Methodology/Approach: the methodology presented in this paper follows a sequence of methods that: (i) identify the hazards; (ii) evaluate the probability of risks associated with each project task; (iii) assess their consequences and impact on project costs; and, finally, (iv) quantify the risks to predict a probability spectrum for the project’s total cost. This allows estimating an emergency reserve and categorizing the risk level to inform stakeholders.
Findings: The paper reveals that, among the 66 identified hazards, there is a 37% probability of the project duration exceeding 200 days, and the project has been categorized as high risk (i.e., more than a 20% probability that additional costs will exceed 20% of the estimated project budget).
Research, practical & social implications: this study enables organizations to forecast the potential impacts of risks on project schedules and costs through comprehensive risk assessments, providing valuable input for project risk management.
Originality/ Value: the study’s value lies in the originality of its risk assessment methodology applied to automakers’ body-in-white projects.
Keywords: Automaker. Body-in-White. Monte Carlo Simulation. Probabilistic modeling. Quantitative risk assessment.
Aliya İzzetbegoviç’in Sanat ve Bilim Düşünceleri Üzerine Eleştirel Bir Yaklaşım
Authors: Aksoy Murat
Published: December 2024

XX. yüzyılın en önemli Müslüman düşünürlerinden olan Aliya İzzetbegoviç’in (öl. 2003) birçok düşünce ve kavram üzerine olduğu gibi sanat üzerine de önemli düşünceleri vardır. Çeşitli eserlerinde sanat konusuna değinmiş olmakla birlikte, İzzetbegoviç, sanat meselesini etraflıca Doğu Batı Arasında İslam adlı kitabının “Sanat Fenomeni” bölümünde ele almıştır. Bu bölümdeki alt başlıklardan biri de “Sanat ve Bilim”dir. “Sanat ve Bilim” bölümünde İzzetbegoviç sanatla çeşitli kavramlar, düşünceler ve disiplinler arasındaki ilişkiye ayrıntılı bir biçimde değinmiştir. Kitabın ismi ve temel iddiası açısından İzzetbegoviç 'in sanat ve bilim meselesine de Batının sanat anlayışı ile Doğunun sanat anlayışından farklı bir yaklaşım tarzı benimseyerek meseleleri ele alması beklenmektedir. Oysa İzzetbegoviç sanatı, Batı sanat kuramı ve özellikle modern Batı sanat kuramı ve estetiği bağlamında ele almaktadır. Verdiği sanatçı ve sanat eseri örnekleri tamamen Batı sanatından olduğu gibi iddialarını desteklemek için kullandığı argümanlar da Batı düşüncesine aittir. Bölümde hiçbir şekilde Müslüman bir sanatçı veya sanat eserinin ismi geçmemektedir. İslam’ın sanat anlayışına dair hiçbir İslam düşünürünün fikirlerine de atıfta bulunmamıştır. Herhangi bir Kur’an ayeti veya Hadis, sanat ve bilim arasındaki ilişkiyi çözümlemek için referans gösterilmemiştir. İzzetbegoviç sanat ve bilim arasındaki ilişkiyi çözümlemek için Batının toplumsal, kültürel, felsefi geleneği çerçevesinde bir düşünce perspektifi ortaya koymaktadır. Bölümde İslam kültürüne, felsefesine veya temel metinlerine başvurarak yapılmış bir çözümleme yoktur. Bu çalışma İzzetbegoviç’in Doğu Batı Arasında İslam kitabının “Sanat Fenomeni” adlı bölümdeki “Sanat ve Bilim” başlığı altındaki düşüncelere nitel araştırma yöntemiyle eleştirel yaklaşmayı deneyecektir. Çalışmanın ana iddiası İzzetbegoviç’in sanat ve bilim konusuna Doğu Batı arasında ve İslam'a has bir biçimde yaklaşmadığı yönündedir. İzzetbegoviç sanata bir İslam düşünürü gibi yaklaşmaktan ziyade Batılı ve dahası aydınlanmacı bir düşünür gibi yaklaşmaktadır. Modernitenin gelenek karşısında kutsadığı sanatçı ve sanat eserlerini büyük bir istekle kabul etmekte, sanat anlamında gelenek ve modernitenin kavgasını ve bu kavganın nedenlerini göz ardı etmektedir. Geleneksel /İslam sanatının ne formuna ne içeriğine ne tarihsel gelişimine ne de bugünkü durumuna dair bir fikir ortaya koymamaktadır. Bu anlamda bölümde İslam medeniyetinin sanatsal ve düşünsel birikiminin izlerini sürmek mümkün değildir. Bu yaklaşım biçimi İzzetbegoviç'i sanat konusunda Doğu Batı arasında İslam'a özgü bir konumdan uzaklaştırıp Batılı/ aydınlanmacı bir konuma yerleştirmektedir.
Nûriyye Melâmîleri Divanlarında Yer Alan Bestelenmiş İlâhîler
Authors: Avlar Elif Sena , Arpa Serbülend
Published: December 2024

IX. yüzyılda Horasan bölgesinde ortaya çıkan Melâmiyye, XXI. yüzyıla kadar varlığını sürdürmüştür. Hamdûn el-Kassâr’ın (ö. 884) temsil ettiği Melâmetiyye-i Kassâriyye, Hacı Bayram-ı Velî’nin (ö. 1430) halifesi Ömer Dede Sikkînî’nin (ö. 1475) temsil ettiği Melâmetiyye-i Bayramîyye ve Muhammed Nûrü’l-Arabî’nin (ö. 1888) temsil ettiği Melâmetiyye-i Nûriyye olarak 3 dönemde incelenmektedir. Melâmîliğin bu devrelerine dair akademik düzeyde çalışmalar yapılmış olsa da mûsikî yönüne dair çalışmaların çok az olduğu görülmüştür. Bu çalışmanın evreni Nûriyye Melâmîleri, örneklemi ise Nûriyye Melâmîlerine dair mûsikî ile ilgili çalışmaları kapsamaktadır. Çalışmada Nûriyye Melâmîlerinin edebi ve sanatsal yönü araştırılmış, literatür taraması aşamasında Melâmî tekke ve derneklerinde icra edilen ilahilere güfte olarak kaynaklık eden Melâmî Efendilerine ait divanlar incelenmiştir. Çalışmamızın amacı Melâmî divanlarında yer alan ve ilahi formunda bestelenmiş güfteleri tespit etmek ve bu ilahilerin yaygınlığını belirlemektir. Nitel araştırma yöntemi kullandığımız çalışmamızda birincil veri kaynaklarını; Melâmîler tarafından bizzat kaleme alınan divanlar ve yine Melâmî ihvanı ile yapılan görüşmeler oluşturmaktadır. İkincil veri kaynaklarımız ise Melâmîlik hakkında yazılan tasavvuf kitapları, makaleler ve Melâmî derneklerinin resmi sayfalarında yer alan mevcut bilgilerdir. Tespit edilen divanlardaki bestelenmiş ilahiler için ise Melâmî Divanları, Devlet Nota Arşivi, Cüneyd Kosal Nota Arşivi, Divan Makam ve Notam v1.0 (Aytaç ERGEN) programı üzerinden taranmış, eşleşen ilahiler çalışmamıza dâhil edilmiştir. Nûriyye Melâmîlerine ait 14 adet divan incelenmiştir. Bu divanlar Abdurrahîm Fedâî, Ali Örfî, Ömer Lütfî, İştipli Hacı Salih Rıf’at, Abdulmâlik Hilmî, Hulûsi Maksud, Hüseyin Şemsi Ergüneş, Hasan Fehmi Tezdoğan, Üsküplü İsmail Hakkı, Hafız Ahmet Fethî, Hüseyin Sabri Soyyiğit, Ahmet Soyyiğit, Yaşar İhsan Gülver ve Dâvud Yılmaz’a ait divanın arasından 8 tanesinde yer alan 97 adet ilahinin notaya alındığı tespit edilmiştir. Verilerin değerlendirilmesi aşamasında; yapılan bu bestelerin hem Melâmî tekke ve meclislerinde hem de tekke dışında icra edildiği, bu bağlamda Nûriyye Melâmîlerinin edebi ve sanatsal yönünün tekke dışında da etkin olduğu görülmüştür. Araştırmanın sonucunda Abdurrahîm Fedâî Divanında yer alan 1’i nefes, 1’i deyiş (bu nefes ve deyişler ilahi formu altında listelenmiştir), 12’i ilahi olmak üzere toplam 14, Ömer Lütfî Divanında yer alan 1, Salih Rıf’at Divanında yer alan 2, Hasan Fehmi Tezdoğan Divanında yer alan 20, Üsküplü İsmail Hakkı’ya ait olduğunu tespit ettiğimiz 1, Ahmet Fethi Divanında yer alan 26, Ahmet Soyyiğit Divanındaki 21, Dâvud Yılmaz Divanındaki 12, toplamda 97 eserin ilahi formunda farklı bestekârlar tarafından bestelendiği tespit edilmiştir.
Explorando las Creencias y Conocimientos en Tecnologías del Aprendizaje y el Conocimiento (TAC) de Futuros Docentes de Matemáticas
Authors: Merlano-Meza Daniela Lucía , Valbuena Duarte Sonia , Conde Carmona Robinson Junior
Published: December 2024

Esta investigación tuvo como objetivo caracterizar los conocimientos y creencias de los profesores de matemáticas en formación inicial en relación con el uso de las Tecnologías del Aprendizaje y el Conocimiento (TAC) en la enseñanza de las matemáticas. Se fundamentó en los marcos teóricos del Conocimiento del Contenido Matemático (MCK), las creencias del profesor, el Conocimiento Tecnológico Pedagógico del Contenido (TPACK) en matemáticas y las competencias TAC del profesor propuestas por el Ministerio de Educación Nacional. Siguiendo un diseño metodológico mixto, se trabajó con una muestra de 47 profesores en formación inicial del programa de licenciatura en matemáticas de una universidad pública del Caribe colombiano, empleando técnicas cuantitativas como encuestas en formularios de Google y técnicas cualitativas como grupos focales a través de Google Meet y observación no participante de las prácticas pedagógicas. Los hallazgos revelaron una mínima utilización de estrategias didácticas guiadas por las TAC, un conocimiento limitado de software especializado en matemáticas, una escasa implementación de recursos tecnológicos en la formación de profesores de matemáticas y, en consecuencia, una limitada integración de las tecnologías en las prácticas pedagógicas, así como dificultades en la integración pedagógica, didáctica y metodológica al enseñar contenidos matemáticos con la incorporación de las TAC, debido al mínimo conocimiento de los profesores formadores y la insuficiente integración de estos recursos a través del currículo.
Baseline characteristics of hypertensive patients with descending thoracic or abdominal aortic aneurysm referred for endovascular treatment
Authors: Gurevich A. P. , Ionov M. V. , Emelianov I. V. , Vanyurkin A. G. , Panteleeva Yu. K. , Chernov A. V. , Chernyavsky M. A. , Konradi A. O.
Published: December 2024

Aim. To analyze perioperative characteristics, including central hemodynamic parameters, of patients with hypertension (HTN) and descending thoracic aortic aneurysm (TAA) or abdominal aortic aneurysm (AAA) who were referred for endovascular aortic repair ([T]EVAR).

Material and methods. Local registry data were used. The study included 126 patients (103 men, 67±9 years). In addition to the basic examination, noninvasive measurement of central blood pressure (BP) and carotid-femoral pulse wave velocity (cfPWV) was performed. Quality of life (QOL) was assessed using the EQ-5D-3L questionnaire.

Results. The most common comorbidities were coronary artery disease (68%), obesity (39%), chronic kidney disease (26%), and type 2 diabetes (18%). Patients with AAA were significantly older and had a higher comorbidity burden, but had a better QOL than patients with TAA (59% vs 71%, p<0,05. High medication adherence was noted in 31% of patients receiving an average of 2 antihypertensive drugs and 59% of them had controlled HTN. Carotid-femoral PWV was higher (10,9 vs 9,6 m/s, p=0,006) and augmentation index (AIx) was lower in TAA (21% vs 29%, p<0,001). Large aneurysm size was associated with lower cfPWV and increased central diastolic BP (p=0,01 and p=0,03, respectively). Increased central pulse pressure (CPP) was positively associated with left ventricular mass index (r=0,21, p=0,037). A decrease in CPP and AIx was observed after [T]EVAR.

Conclusion. Patients with HTN and TAA/AAA referred for [T]EVAR have a high comorbidity burden and high QOL. Although the vast majority of patients receive a combination of only two drugs, insufficient adherence to therapy has been revealed. An increase in aneurysm diameter is associated with a decrease in cfPWV and increased central diastolic BP, indicating a potential impact of aneurysm on central hemodynamics in patients receiving antihypertensive therapy.
Comparison of cardiac morphological and functional changes according to magnetic resonance imaging with the genetic testing data in patients with hypertrophic cardiomyopathy
Authors: Gagarina E. V. , Mershina E. A. , Chumakova O. S. , Myasnikov R. P. , Kulikova O. V. , Kudryavtseva M. M. , Sinitsyn V. E.
Published: December 2024

Aim. To analyze the data of cardiac magnetic resonance imaging (MRI) of patients with hypertrophic cardiomyopathy (HCM) depending on the results of genetic testing.

Material and methods. The study included 83 patients with a diagnosis of HCM (39 men, 44 women, mean age 50,4±14,9 years) who had no contraindications to MRI. Cardiac MRI was performed on 1,5 T and 3 T MRI systems using a standard protocol. T1 and T2 mapping was performed in 41 patients, and the extracellular volume fraction was estimated. All patients underwent genetic testing with assessment of sarcomeric genes, two non-sarcomeric genes associated with HCM, and genes of syndromic diseases (HCM phenocopies).

Results. Positive results of genetic testing were obtained in 49 (59%) of 83 patients: MYBPC3 29%, MYH7 17%, TPM1 5%, FLNC 4%, MYL2 2%, TNNC1 1%, TNNI3 1% (genotype-positive group (G+)). Negative results of genetic testing were obtained in 34 (41%) patients (genotype-negative group (G-)). In the G-group, patients were significantly older than in G+ (57,7±12,9 vs 45,3±14,2 years, p<0,05), with a smaller left ventricular (LV) wall thickness (18,9±4,2 vs 21,3±5,9 mm, p<0,05), and a higher LV ejection fraction (70,5±10,7 vs 64,7±10,4%, p<0,05). Comparison of myocardial fibrosis parameters between the groups showed a significantly lower incidence of delayed contrast enhancement in the G-group, and in its presence, the fibrosis severity, which was assessed as the fibrosis percentage from the total LV mass, was significantly lower than in the G+ group (71% vs 92%; 5,0±8,0% vs 11,4±9,0%, respectively, p<0,05). When analyzing G+ patients depending on the identified mutations, no significant difference in the severity of fibrosis was found between the groups.

Conclusion. In patients with HCM, a positive genetic analysis, regardless of the affected gene, is associated with a greater severity of fibrosis according to MRI data, which indicates a less favorable prognosis.
Development of predictive models for differential diagnosis of hypertrophic cardiomyopathy
Authors: Zaitsev V. V. , Safronov K. S. , Konasov K. S. , Bavshin T. R. , Manokhin K. A. , Obraztsova L. A. , Moiseeva O. M.
Published: December 2024

Aim. To develop predictive models for differential diagnostics of hypertrophic phenotype in patients with concomitant diseases, as well as to validate through independent assessment.

Material and methods. The study included an analysis of 1169 medical records from the medical information system of patients with severe myocardial hypertrophy and a preliminary diagnosis of hypertrophic cardiomyopathy (HCM) (I42.1, I42.2). The patients were divided into 3 following groups: patients with a probable HCM, patients with moderate myocardial hypertrophy (>15 mm) due to a known disease, and patients with severe myocardial hypertrophy that cannot be explained by left ventricular pressure overload ("gray zone"). The original dataset contains 74 parameters. Machine learning models of the following classes were created and optimized: logistic regression, support vector machine, decision tree, and gradient boosting decision trees.

Results. All models have sufficient accuracy in detecting HCM, but the accuracy of ruling out the diagnosis is quite low. The use of a machine learning model using logistic regression reduced the HCM misdiagnosis risk in the group of questionable diagnosis to 31%.

Conclusion. Four predictive models for differential diagnosis of severe left ventricular myocardial hypertrophy were developed to improve the HCM diagnosis. Blinding validation showed that logistic regression is the most optimal model for clinical practice.
Abnormalities of the nocturnal blood pressure profile: significance, diagnostic possibilities, and therapeutic approaches
Authors: Kobalava Zh. D. , Troitskaya E. A.
Published: December 2024

Impaired 24-hour blood pressure (BP) profile is receiving increasing attention due to improved detection capabilities, increased incidence, and confirmed associations with cardiovascular risk. However, there are gaps or conflicting data in knowledge about nocturnal hypertension (HTN) and non-dipping. The review focuses on current problems associated with elevated nocturnal BP with an emphasis on diagnostic capabilities, prognostic significance of changes and treatment options.
2024 Clinical practice guidelines for Chronic heart failure
Authors: Galyavich A. S. , Tereshchenko S. N. , Uskach T. M. , Ageev F. T. , Aronov D. M. , Arutyunov G. P. , Begrambekova Yu. L. , Belenkov Yu. N. , Boytsov S. A. , Bubnova M. G. , Vasyuk Yu. A. , Villevalde S. V. , Vinogradova N. G. , Garganeeva A. A. , Gendlin G. E. , Gilyarevsky S. R. , Glezer M. G. , Gautier S. V. , Grinstein Yu. I. , Dovzhenko T. V. , Drapkina O. M. , Duplyakov D. V. , Zhirov I. V. , Zateishchikov D. A. , Zvartau N. E. , Irtyuga O. B. , Kobalava Zh. D. , Koziolova N. A. , Koroteev A. V. , Libis R. A. , Lopatin Yu. M. , Mareev V. Yu. , Mareev Yu. V. , Matskeplishvili S. T. , Mikhailov E. N. , Nasonova S. N. , Narusov O. Yu. , Nedogoda S. V. , Nedoshivin A. O. , Ovchinnikov A. G. , Orlova Ya. A. , Perepech N. B. , Pogosova N. V. , Rimskaya E. M. , Samko A. N. , Saidova M. A. , Sapelnikov O. V. , Safiullina A. A. , Sitnikova M. Yu. , Skvortsov A. A. , Skibitskiy V. V. , Stukalova O. V. , Tarlovskaya E. I. , Tereshchenko A. S. , Chesnikova A. I. , Fedotov P. A. , Fomin I. V. , Khasanov N. R. , Shevchenko A. O. , Shaposhnik I. I. , Shariya M. A. , Shlyakhto E. V. , Yavelov I. S. , Yakushin S. S.
Published: December 2024

Russian Society of Cardiology (RSC)

With the participation: National Society of Myocardial Diseases and Heart Failure, Society of Heart Failure Specialists, Russian Scientific Medical Society of Internal Medicine

Endorsed by the Research and Practical Council of the Ministry of Health of the Russian Federation (12.09.2024)
Exercise Does Not Prevent Thermoregulatory Adaptation to Cold Stress During the Winter Season
Authors: Kim Dae-Hwan , Jang Min-Hyeok , Han Jean-Hee , Kim Jung-Hyun
Published: December 2024

PURPOSE: Despite the growing need for recreation and work in cold environments, which often involve high levels of physical activity and significant body heat loss, studies investigating the impact of exercise during repeated cold exposure on cold adaptation are lacking. Therefore, this study aimed to examine whether exercise during repeated cold exposure during winter influences thermoregulatory adaptation to cold.METHODS: Forty young male participants were recruited and classified into two groups: cold weather athletes (CA) who spent at least 10 hr per week training outdoors, and non-athletes (CON) who did not regularly exercise outdoors but were naturally exposed to cold during the winter season. Physiological and perceptual thermoregulatory responses were assessed before and after winter.RESULTS: After winter (December-February), both groups exhibited cold habituation features (p<.05; higher body temperature, blunted sympathetic response, and attenuated cold sensitivity), except for cold pain in the CA group. The cold-induced vasodilation (CIVD) response was enhanced in both groups (F=6.864, p=.034), as indicated by the higher temperature parameters of the fingers (Tmax, Tmean, and Tmin). However, the enhanced temperature response did not translate into improved manual dexterity following cold-water immersion (F=0.041, p=.841).CONCLUSIONS: Exercise during repeated cold exposure did not prevent overall thermoregulatory adaptation after winter. However, the CA group exhibited an attenuated habituation to cold pain, suggesting a potential area for future research on the effects of exercise on cold adaptation. Although the CIVD response improved, it did not result in better fine manual dexterity after cold immersion. These findings highlight the need for further studies of the biological advantages of CIVD.
Collagen Gene Variants and Anterior Cruciate Ligament Rupture in the Korean Population
Authors: Seong Ki-Hoon , Kim Kwang-Jun , Park Hee-Jung , Lee Byung-Hoon , Chang Eunwook , Park Dong-Ho
Published: December 2024

PURPOSE: Anterior cruciate ligament rupture (ACLR) is a common knee ligament injury that occurs in sports. The precise etiology of ACLR remains unknown. Previous studies in various ethnic groups have confirmed an association between genetic variants and ACLR; however, no such research has been conducted in Koreans. This study aimed to investigate whether certain single nucleotide polymorphisms (SNPs), namely COL3A1 rs1800255, COL5A1 rs12722, COL12A1 rs970547, and COL5A1 rs13946, are associated with ACLR in the Korean population.METHODS: This study involved 60 ACLR patients (ACL group, average age 29.9±10.9 years) and 328 control subjects (CON group, average age 23.8±4.1 years). All the participants were genotyped for COL3A1 rs1800255, COL5A1 rs12722, COL12A1 rs970547, and COL5A1 rs13946.RESULTS: No significant genotypic differences were found for COL3A1 rs1800255 (p=.565), COL5A1 rs12722 (p=.779), COL12A1 rs970547 (p=.193), or COL5A1 rs13946 (p=.356). Furthermore, no significant differences were observed between the homozygous and dominant models for each SNP or between the haplotypes of COL5A1 rs12722 and rs13946 (p=.118). However, a significant association with ACLR was observed for the genotype combinations COL3A1 rs1800255 and COL5A1 rs12722 (p=.02).CONCLUSIONS: The results of this study indicate that specific genotypes (SNPs) COL3A1 rs1800255 and COL5A1 rs12722 may influence the occurrence of ACLR. Considering the results and limitations of this study, future research should focus on increasing the sample size, particularly by including both male and female patients of diverse ages, to further validate these findings.
Experimental studies of the «Sila» node
Authors: Moskalev Mihail
Published: December 2024

This article addresses the issues of wood shrinkage and the associated deformations that lead to cracks in log structures. Special attention is given to deformations in houses made of rounded logs. These deformations occur due to uneven changes in the geometry of the wood during drying, leading to high stresses and longitudinal cracks. Various methods are proposed to minimize these deformations, including the use of spring-loaded compensators like the «Sila» node.
The article describes experimental studies conducted to assess the load-bearing capacity of these nodes. The experiments included pull-out and compression tests conducted in the laboratory of SPbGASU. The results showed that the average destructive force for the pull-out test was 2 267 kN, significantly exceeding theoretical values according to current standards. In the compression test, the average maximum force was 364 695 N, approximately 10 % higher than theoretical calculations.
The authors conclude that it is possible to increase the load-bearing capacity of these nodes by using stiffer springs. The article also provides a detailed discussion of the methodologies and results of the tests, analyzing the reasons for discrepancies between experimental data and theoretical calculations. Theoretical justifications and experimental data make this article useful for professionals in the field of wooden construction and engineering, as well as for those involved in the development and implementation of new construction technologies. The provided data and methods ensure reliable and durable log connections, reducing the likelihood of cracks and improving the operational characteristics of log structures.
Consulting as an evolving tool for ensuring economic security of business entities
Authors: Strakhov Ivan
Published: December 2024

This article is devoted to the analysis of the use of consulting as a tool for ensuring economic security of business entities, revealing the essence of consulting not only as a managerial, but also as an economic evolving process.
The relevance of the research topic is due to the fact that consulting, helping companies adapt to rapidly changing conditions, optimize their processes and achieve sustainable development, begins to play a more important role in the modern economy than just a management process. In the era of globalization and intensification of competition, when economic relations are becoming increasingly complex and multifaceted, high-quality consulting is becoming not just desirable, but a necessary condition for the success of any organization.
In the article, the author analyzes the basic concepts and approaches to consulting activities, characterizes the modern model of consulting activities, describes the features of interaction between clients and consulting at present, and identifies current areas of modification of modern consulting.
The researcher paid special attention to the fact that in modern conditions, consulting has acquired special significance as an integral element of effective management of an organization. A deep analysis of this phenomenon allows us to trace the significant evolution of consulting services, which have gone from simple forms of expert support to complex integrated solutions.
The article examines the features of the transformation of consulting services: if earlier consulting was limited to diagnostic, expert and process models, today we are witnessing a qualitatively new level of consulting interaction. The modern approach is characterized by complexity and consistency, where the consultant and the client act as equal partners in solving business problems. Such a partnership allows achieving a synergistic effect, when the experience and expertise of the consultant are organically combined with the client's deep understanding of the specifics of his business.
The result of the study was the author's conclusion that consulting has gone far beyond a purely management tool. Today it is a full-fledged economic process that has a transformative effect on all aspects of the organization's activities. Its impact covers the production and financial spheres, affects personnel management issues, extends to environmental and legal aspects of business. Such comprehensive nature of modern consulting makes it a powerful catalyst for organizational change and development.
Asymptotic normality of the kernel estimator of the recursive density under the censored \(\beta \)-mixing model
Authors: Mar Mouhamed , Diouf Saliou , Dème El Hadji
Published: December 2024

In this paper, we establish the asymptotic normality of the recursive estimator of the density function for the
right-censored random model when the data present some form of dependence. It is assumed that, the survival and
the censoring times form a stationary \(\beta\)-mixing-mixing. Therefore this paper is part of this vast project
aimed to extending the results obtained with independent variables in the dependent case.
Kernel estimation of the conditional probability density function and Mode in presence of functional covariate and censorship
Authors: Dabana Hézouwè , Agbokou Komi , Gneyou Kossi Essona
Published: December 2024

In the literature, several authors have worked on the nonparametric estimation of conditional density when the data is censored.
In this work, we tackle the same theme with the kernel method by considering the case of censored and dependent data of the
algebraically \(\alpha\)-mixing type in the presence of functional covariate. We establish the almost complete convergence of this
estimator and that of mode. Finally, we carry out a numerical study to evaluate the performance of these estimators.
Specialprofessioner i en re-centraliserad skola
Authors: Andersson Andreas , Dahlin Linda , Erickson Theresa , Röing Kristina , Höstfält Gabriella
Published: December 2024

Specialprofessionernas professionalisering under tre reformperioder: 2007-2011; 2012-2016; 2017-2021.
Speciallärares och specialpedagogers roller, makt och autonomi i skolans organisation
Authors: Burman Anna , Troedson Nicklas , Wermke Wieland
Published: December 2024

Hur speciallärare och specialpedagoger får särskilda, men också olika, roller i maktförskjutningarna inom skolans värld.
THE USE OF FLOW MIXERS IN OXIDIZED BITUMEN PRODUCTION
Authors: Vyakherev Nikita S. , Sidorov Georgy M. , Makhmutova Alina R.
Published: December 2024

In the process of road bitumen production, the raw material mixture is fed into an oxidizing column, where it is oxidized with air oxygen. Using this production method, a large amount of oxygen, without reacting, is sent to the scrubber and then to the afterburning furnace. One of the ways to use air oxygen more efficiently in the process of oxidized bitumen production is the use of pre-oxidant mixers. There is also a problem related to such a quality indicator as bitumen aging due to the use of air for mixing commercial bitumen, this problem is solved in a similar way – using a flow jet hydraulic mixer with a cone swirl. This article compares the existing remote gas-liquid cavitation vortex apparatus with a flow jet hydraulic mixer based on building their models in the Ansys CFX program and determining the air concentration in the mixture passing through the mixer. This indicator will reveal the most effective apparatus for the preoxidation of raw materials for bitumen production. A simulation of the flow of tar through a flow jet hydraulic mixer with a conical flow swirl is also performed to determine the turbulence and turbolization of the flow, which shows its effectiveness in mixing compounded bitumen.
RISK ASSESSMENT BASED ON THE OCCUPATIONAL RISK MAP OF PHARMACEUTICAL PRODUCTION WORKERS
Authors: Mindiyarova Emma A. , Solop Gulnara R. , Solop Sergey A. , Khanzhina Darya N.
Published: December 2024

The article is devoted to assessment of occupational risks threatening the health of pharmaceutical production workers. The process of identification, analysis and assessment of risks, as well as the development of measures to manage them in accordance with the legislative framework for labor protection are presented. The article provides an example of the application of these methods at the Scientific and Production Association «Mikrogen», which produces immunobiological drugs, and also examines in detail hazardous production factors for various workplaces. The final analysis presents the results of various risk assessment methods and confirms the importance of a systematic approach to labor protection in pharmaceutical production.
Vibrotactile perception depends on cognition not just peripheral nerve integrity: a cross-sectional study
Authors: Robbins Nathaniel , Bujarski Krzysztof , Stark Aleksandra , Palladino Thomas , Bursey Julie , Mason Stephen , Stommel Elijah , Lawson Victoria
Published: December 2024

Background:  Vibration perception is often considered a peripheral nerve and dorsal column function, without considering the role of cognition. The current study tested cognition’s role in vibrotactile perception thresholds (VPT).
Methods:  We recruited cases with mild-moderate dementia or mild cognitive impairment thought to reflect probable Alzheimer’s pathology (AD/MCI group), and controls without memory concerns (all participants >50 years). Polyneuropathy, B12 deficiency, diabetes, or other conditions associated with cognitive impairment were exclusionary criteria. Participants underwent cognitive evaluation with the Self-Administered Gerocognitive Examination (SAGE), standardized nerve conduction studies, and quantitative VPT testing. Demographic and medical history were obtained through interview and chart review. We constructed linear regression models to test whether poor cognition correlates with VPT. 
Results: Nineteen AD/MCI participants (age 71.5±8.9, 47.4% female) and fourteen controls (age 67.4±9.3, 78.6% female) did not differ on age or gender. Univariate predictors of poor/increased mean VPT (all p­-values <0.10) were age, AD/MCI, SAGE score, sural sensory nerve action potential (SNAP) amplitude <5 microvolts, yearly income <$50,000, history of vascular disease, and peroneal motor and sural conduction velocity (CV). SAGE score (standardized β=-0.38, p<0.01); sural SNAP amplitude (β=0.51, p<0.001); peroneal motor CV (β=-0.37, p<0.01), history of vascular disease (β=0.27, p=0.03), and female gender (β=0.22, p=0.10) remained independently associated with VPT in multivariable linear regression analysis (backwards modeling; removal criteria p>0.10; model adjusted R2=0.66; p<0.001).
Conclusions: Poor cognition is associated with worsened VPT. Neurologists should consider cognition when using sensory perception to assess peripheral nerve integrity, both for research and during a traditional neurologic examination.
RelaRelación entre Burnout y las competencias digitales en el proceso de enseñanza-aprendizaje de los docentes universitarios peruanos durante la pandemia COVID-19
Authors: Pérez Narrea Julio César , Mendoza-García Erica , Guevara Ingelmo Raquel María , Moral-García José Enrique
Published: December 2024

La pandemia COVID-19 ha generado un impacto de gran relevancia en la educación superior de todo el mundo. En Perú, la situación de confinamiento vivida durante el estado de alarma supuso la suspensión de las clases presenciales y un proceso de adaptación a una realidad educativa que hizo que millones de personas continuaran con su formación desde casa. Esto significó un verdadero reto para el profesorado universitario, que, ante un modelo de educación a distancia de emergencia, tuvo que acomodarse a una modalidad docente compleja con diversas opciones tecnológicas y pedagógicas sin precedentes.  Este fenómeno hizo desencadenó o aumentó el estrés conocido como Burnout del docente. El presente estudio de tipo transversal, descriptivo mediante encuesta, analizó el impacto del burnout sobre la competencia digital y su relación con factores sociodemográficos en docentes universitarios peruanos. Participaron 274 docentes (105 mujeres, 169 varones). Los resultados mostraron relación significativa entre el Burnout y las Competencias Digitales, así experimentaron mayor Burnout presentaron menor competencia digital. Por otro lado, existe diferencia significativa según los años de experiencia en la docencia, teniendo un mayor nivel de competencia digital en la dimensión pedagógica, y en la dimensión de despersonalización y falta de realización personal de Burnout.
Из опыта западного конституционализма: политико-правовые аспекты модернизации Конституции Канады
Authors: Danilov Sergey
Published: December 2024

Настоящая работа посвящена формам и средствам преодоления правовых и политических препятствий, обычно встающих на пути модернизации высшего закона государства. В качестве иллюстрации автором избраны основополагающие моменты современного конституционного процесса Канады. Она является одним из старейших и наиболее уважаемых конституционных демократических федеративных государств, принадлежащих к правовой семье стран «общего права». В статье вскрываются основополагающие и специфические черты исторически сложившегося в этом североамериканском государстве механизма конституционно-правового регулирования социальных отношений. Автором обращено внимание на имманентно негативные последствия терминологической путаницы и других огрехов юридической техники, неизбежно сказывающиеся затем в правовой доктрине и конституционной практике. При изучении развития конституционализма в созданной канадцами модели федеративного государства особенное внимание отведено распределению предметов компетенции между двумя уровнями государственной власти — федеральной и провинциально-субъектной, равно как и ключевым моментам в динамике отношений между ними. В том числе автором рассматривается роль и место таких источников правового регулирования, как конституционно-правовой обычай и судебный прецедент, в конституционной доктрине и практике изучаемой страны. Подчеркивается достигнутое канадцами многообразие способов взаимодействия федерального уровня власти и провинций. Автор определяет степень необходимости и целесообразности конституционной реформы конца ХХ в., прослежены ее основные этапы. В статье исследуется вклад, внесенный в проведение данной реформы органами судебной власти канадских провинций и федерации, в том числе в судебном деле о патриации Конституции. В статье проводится мысль о пользе, которую приносит обществу и государству неукоснительное соблюдение институтами власти принципа верховенства права, в том числе их отказ от идеи подчинения права «практическим» соображениям экономического порядка, а также следование органов исполнительной власти воле и решениям судебных инстанций. Отмечается органическая связь между реформой высшего закона страны и утверждением ее суверенных прав в отношениях с прежней метрополией — Соединенным Королевством Великобритании. Автором проанализировано воздействие, которое конституционная реформа оказала на современное развитие канадского государства в целом и конституционализма в частности. В статье также дана положительная оценка качества и уровня управленческого искусства, которое было проявлено институтами федеральной власти и их должностными лицами во время реализации конституционной реформы.
Изменения в «Общие положения об обязательствах» ГК РФ. Обзор обсуждения на факультете права НИУ ВШЭ
Authors: Getman-Pavlova Irina V.
Published: December 2024

23 мая на факультете права НИУ ВШЭ состоялось обсуждение изменений в Гражданском кодексе РФ, которые должны вступить в силу с 1 июня 2015 г. В обсуждении принимали участие профессора и преподаватели Кафедры гражданского и предпринимательского права НИУ ВШЭ — Э.П. Гаврилов, А.А. Иванов, М.В. Кротов, К.А. Новиков, а также преподаватели других кафедр и студенты факультета права. Обсуждались в основном общие положения об обязательствах — понятие обязательства, принципы исполнения обязательств, ответственность за неисполнение обязательств, способы обеспечения исполнения обязательств, а также прекращение обязательств. Обсуждение преследовало цель не только прокомментировать изменения Гражданского кодекса РФ в догматическом ключе, но оценить их в историческом контексте, понять их логику и смысл.
Интеллектуальная собственность: между правом и политикой
Authors: Bogdanovskaya Irina
Published: December 2024

Рецензия на книгу: Haunss S. Conflicts in the Knowledge Society. The Contentious Politics of Intellectual Property. Cambridge: Cambridge University Press, 2013. 281 p.
Международно-правовое регулирование помощи развивающимся странам в системе международных экономических отношений
Authors: Pomazan A.
Published: December 2024

В настоящей работе объектом исследования является процесс образования, а также современное состояние правовых и политических норм, направленных на оказание международной помощи странам, испытывающим особые потребности в области развития. Целью работы является получение нового научного знания о формировании совокупности обычных международно-правовых норм, а также политических обязательств, принятых на международном уровне в интересах развивающихся и наименее развитых стран. Автор использует исторический и логический методы научного познания, проводит анализ развития международных экономических отношений, складывающихся в процессе оказания помощи развивающимся странам. Статья содержит исторический анализ исследуемой проблемы с учетом положений таких важных документов, как Всеобщая декларация прав человека 1948 г., Декларация о праве на развитие 1986 г., Декларация об окружающей среде и развитии 1992 г., Декларация тысячелетия 2000 г., Йоханнесбургская декларация об устойчивом развитии 2002 г., Стамбульская декларация о наименее развитых странах 2011 г., Декларация РИО+20, Аддис-Абебская программа финансирования развития 2015 г. и др. Автор исследует оказание международной помощи развивающимся странам в таких областях, как торговля, внешняя задолженность, техническая помощь, увеличение объемов финансирования и прямых иностранных инвестиций, международное содействие внутренним реформам, оказание официальной помощи в целях развития и др. В статье также проводится исследование институциональной основы международных экономических отношений в интересах развивающихся стран — дано описание основных направлений деятельности в области развития Группы Всемирного Банка, Международного валютного фонда, Всемирной торговой организации, иных специализированных учреждений ООН. Автор приходит к выводам о формировании комплекса международно-правовых, а также политических обязательств, принятых большинством государств и направленных на построение устойчивых экономических отношений в целях всеохватного экономического роста в интересах нуждающихся стран. Автор резюмирует наличие тесной взаимосвязи международных норм в области содействия социально-экономическому развитию нуждающимся странам с реализацией одного из важнейших международных прав — права на развитие, закрепленного в Декларации 1986 г.
Key Challenges to the Long-Term Growth of the US Economy
Authors:   HSE University, Grigoryev Leonid
Published: December 2024

Экономика США в XXI в. продолжает рост по традиционной траектории, сталкивается со старыми и новыми проблемами, испытывает внешние шоки и внутренние социально-экономические трудности. Но страна растет быстрее Европейского союза и стремится сохранить лидерство в сфере НТП. Уровень благосостояния растет, хотя отрыв состоятельных слоев от основной массы населения не уменьшается. Электоральный процесс в двухпартийной политической системе регулярно обостряет дебаты по ключевым вопросам экономической политики, в результате чего постоянно идет трудный поиск компромиссов. Выборы 2024 г., закончившиеся победой Дональда Трампа и Республиканской партии, иллюстрируют значительный раскол во взглядах электората (и элит) на социально-экономическую политику и предвещают новые перемены в методах решения ключевых проблем страны.

XXI век — нелегкий для США и их элит: страна преодолела несколько тяжелых кризисов и претерпевает сложную межпартийную борьбу. Президенты страны этой четверти века представляли весьма различные направления мысли и действия. Следующая администрация получает в наследство значительный набор сложностей, включая высокое неравенство, экологические проблемы, стареющую инфраструктуру, растущий государственный долг.

Постоянными источниками выгод для экономики США являются значительный приток дешевой рабочей силы из Латинской Америки и огромные капиталовложения извне в американскую экономику. В последнее десятилетие страна начала активно использовать методы промышленной политики. Все это дает высокие на фоне других развитых стран темпы экономического роста. Но глубокое социальное неравенство встроено в экономическую модель страны даже при общем росте доходов.