bluuebunny/crossref_metadata_2025 huggingface dataset:
IMPLEMENTASI DESIGN THINKING DALAM PENGEMBANGAN BISNIS UMKM MELALUI PLATFORM INSTAGRAM: STUDI KASUS DAPUR QUEENSHA
Authors: Fathurahman Dennis , Maharani Safira , Hodizah Siti , Mazia Lia
Published: May 2024

The development of information technology enables UMKM to reach a wider market through digital marketing, allowing them to attract more customers. This study discusses the implementation of Design Thinking in business development for UMKM, with a case study on Dapur Queensha, a frozen food business. The aim of this research is to enhance the understanding of Design Thinking implementation in UMKM business development using the Instagram platform. This research adopts a descriptive qualitative approach, where data is collected through observation and interviews. The analysis results indicate that Dapur Queensha is striving to promote its products through social media platforms, especially Instagram. The adopted marketing strategy involves leveraging Instagram to market their frozen food products. The proposed solution includes creating attractive and consistent feed designs to post on Instagram and redesigning the existing logo to make it more appealing and simple. Positive feedback from consumers and Instagram users indicates that the design changes have had a positive impact. Additionally, the decision to use Instagram as a marketing tool has proven effective, given its popularity and ability to reach a broad audience.
MARGINAL GAINS IN ESOPHAGECTOMY
Authors:   , Janssen Henricus Josephus Bernardus
Published: May 2024

The number of patients diagnosed with esophageal cancer has been increasing for years. After chemotherapy and radiotherapy, patients often undergo esophagectomy. Esophagectomy is a complex and demanding procedure with various short and long-term consequences. Recent advancements such as introduction of minimally invasive surgery and enhanced recovery after surgery programs have significantly improved outcomes after surgery. Nonetheless, complications involving the lungs and leakage of the connection between the esophagus and the newly formed 'gastric conduit’ (anastomotic leakage) are still common.

The research in this dissertation focused on optimizing the care pathway for esophageal cancer patients undergoing esophagectomy, according to the 'marginal gains' principle. A surgical technique, partly derived from bariatric surgery, which has been further developed at the Catharina Hospital (Eindhoven, the Netherlands), was shown to have a low percentage of anastomotic leakage. A Dutch nationwide study showed that hospitals performing both bariatric surgery and esophagectomy, tend to have better outcomes in terms of complications and hospital stay after esophagectomy. Additionally, at the Catharina Hospital, complication rate declined over the years from ±67% to ±39% (pneumonia from ±37% to ±14%) and length of hospital stay was reduced from ±9 days to ±6 days due to two fundamental innovations: prehabilitation before and directly starting oral intake after esophagectomy. Furthermore, it was found that nutritional supplements after surgery are important in reducing the risk of micronutrient deficiencies. Finally, two animal studies have indicated that there may be a role for neurostimulation: the (electrical) stimulation of nerve(s) to reduce inflammation and complications after surgery.
Study the Effect of BTCA Crosslinking Agent on Crease Recovery Angle and Washing Shrinkage Properties of Bleached and Dyed with Bi- and Tri- Functional Reactive Dyed Woven Cotton Fabric
Authors: Hassen Yimer
Published: May 2024

Easy care finishing of textile materials is one of textile chemical finishing processes to make cellulosic textile materials crease free and dimensionally stable in its service life or during wear. There are different types of crosslinking agents for easy care finishing of cotton fabric. Among these, 1,2,3,4-buthanetetracarboxylic acid is the most effective and formaldehyde free crosslinking agent. On the other hand, woven cotton fabric treated with reactive dyes to give color to textiles. It reacts with fiber in presence of alkali and forms covalent bond with hydroxyl group of cellulosic fibers. In this study, therefore, investigates the effect of covalent bond formation between reactive dyes and cellulose fiber on crease angle recovery and washing shrinkage percentage properties after treated with BTCA crosslinking agent. Initially, cotton fabric was treated with reactive dyes using cold-pad-batch method and followed by easy care finishing for both bleached and dyed fabric using pad-dry-cure method. The application of Bi- and Tri- functional reactive dyes reduces the total crease recovery angle and Tri- functional reactive dye improves the washing shrinkage percentage properties of cotton fabric.
Contribución de la musicoterapia a la calidad de vida laboral en una empresa de telecomunicaciones
Authors: Lotero Chamorro Diana Carolina , Maya Urrego Sara Lucía , Gómez Granada Bibiana Marcela
Published: May 2024

La presente investigación tuvo como propósito analizar la contribución de la musicoterapia en la Calidad de Vida Laboral en un grupo de trabajadores de una empresa de telecomunicaciones con sede en el municipio de Itagüí. La investigación se abordó desde una mirada cualitativa con enfoque fenomenológico; se aplicó la estrategia del estudio de caso y técnica de la entrevista semiestructurada y para la intervención musicoterapéutica fueron utilizados los métodos musicoterapéuticos (improvisación, recreación, composición y método receptivo). Como resultados del estudio se encontró que la musicoterapia ayuda a fortalecer las relaciones interpersonales, el empoderamiento, la comunicación y salud mental y física de los trabajadores, aportando así a su Calidad de Vida Laboral.
Laboratorio de innovación ¿… y ese empaque qué?
Authors: Aguirre Alvarez Yenny Alejandra , Montoya Peláez Mauricio
Published: May 2024

Las estrategias lúdicas son prácticas utilizadas en la academia y la industria para fortalecer el aprendizaje de competencias, tales como la resolución de retos. Docentes del Politécnico Colombiano Jaime Isaza Cadavid y la Universidad de Antioquia diseñaron una estrategia lúdica para interiorizar los conceptos del curso “Empaque y embalaje”, considerando restricciones del producto y criterios de toma de decisiones; ello dio origen al “Laboratorio de innovación ¿…y ese empaque qué?”. La metodología parte de la necesidad teórica-práctica del curso; la estrategia lúdica está fundamentada en el aprendizaje basado en proyectos y se analizan los datos de la ejecución. Como resultado, se tiene una valoración de los participantes de 4,67 sobre 5,0, al considerar cuatro ítems relacionados con sus percepciones y experiencia durante el desarrollo del laboratorio lúdico: nivel de enseñanza-aprendizaje, similitud con realidades empresariales, proceso vivencial para resolver problemas y simplicidad/facilidad del logro de objetivos.
International Humanitarian Law Study of the Protection of the Rohingya Community in Indonesia
Authors: Frahma Elen Anedya
Published: May 2024

Until December 2023, the number of Rohingya refugees in Indonesia continues to increase, with more than 1500 Rohingya living in Indonesia.  This situation poses ongoing challenges for Indonesia, both in terms of increasing numbers of refugees and in the policies and solutions needed to address this problem.  This research aims to explore Indonesia's role in the case of the Rohingya ethnic group based on the concept of Responsibility to Protect (R2P) and to highlight legal protection and human rights for Rohingya refugees in Indonesia.  The research method used is normative research to investigate how Indonesia handles the issue of Rohingya ethnic refugees in the international social context and legal system in Indonesia.  The research results show that diplomatically, Indonesia has attempted to resolve the conflict in Myanmar through various steps, including active diplomacy and support for inclusive development and the capacity of the Myanmar government.  Even though Indonesia has not ratified the 1951 International Convention and the 1967 Protocol on the Status of Refugees, the Indonesian government, especially the Aceh regional government, is seriously providing assistance and protection to Rohingya refugees by providing temporary shelter, living facilities and health services.
Keywords: International Humanitarian Law, Protection Rohingya Community, Humanitarian Law
BENTUK PENYAJIAN DAN SINEMATOGRAFI KARYA SINEMA TARI MANYINGKAI PANGAMBANGAN MEMBUKA TABIR PANGAMBANGAN SEBAGAI PRODUKSI TARI
Authors: Miradalina  , Sutardi Edi , Kinanthi Purnama Asri Adinda Gita
Published: May 2024

Tari Manyingkai Pangambangan Membuka Tabir Pangambangan digarap sebagai materi ujian akhir mata kuliah produksi tari tahun 2021 oleh mahasiswa tahun angkatan 2017 Program Studi Pendidikan Seni Tari STKIP PGRI Banjarmasin. Sinema tari ini merupakan bagian inovasi terwujud karena situasi masa Covid-19. Tujuan penelitian untuk mendeskripsikan Bentuk Penyajian dan teknik sinematografi dari Sinema Tari Manyingkai Pangambangan Membuka Tabir Pangambangan sebagai hasil Produksi Tari. Jenis penelitian Kualitatif dengan pendekatan deskriptif, dengan teknik pengumpulan data meliputi observasi, wawancara dan dokumentasi. Hasil penelitian: (1) Bentuk Penyajian Tari, tari kreasi baru berpijak pada gerak tradisi Banjar, memiliki 91 ragam gerak(gerak maknawi dan murni) dan 59 pola lantai. Menggunakan musik pengiring sampling, gamelan dan keyboard. Tata rias berjenis Realis, Kostum dan properti yang dipakai bercirikan budaya khas Kalimantan Selatan. (2) Teknik Sinematografi meliputi camera angle yang meliputi high angle, eye angle, dan low angle untuk mendominasi, membuat keseimbangan pada hasilnya. Type of shot yang digunakan big close up, close up, medium close up, medium shot, full shot, long shot, agar memberikan hasil detail serta keadaan disekitar objek. Camera movement meliputi panning, tilting, dolly, tracking, dan crane sehingga memberi kesan gambaran objek secara menyeluruh dengan keadaan di sekitarnya. Continuity-nya menggunakan content continuity dan movement continuity untuk memberi kejelasan kesinambungan  dari gambar pertama kepada gambar selanjutnya.
Kata Kunci: bentuk penyajian, teknik sinematografi,tari,manyingkai pengambangan.
Same Frame, Different Lens? Exporting Danish Film Style
Authors: Adriaensens Vito
Published: May 2024

The chapter analyses the careers of Danish cameramen who found work in the German film industry, with a particular focus on Axel Graatkjær, who shot most of Nordisk Film Kompagni’s productions before 1910. In collaboration with Karl Freund, he shot a number of Asta Nielsen’s German films. He continued to work in Germany till the end of the silent period, shooting a number of significant films and working with major directors like Lupu Pick, Murnau, Wiene and Paul Czinner. Cinematography is a key component of film style, and the chapter attempts to assess the degree to which cinematographers like Graatkjær were able to imprint the films they worked on with a particular national style.
Pat and Patachon as Transnational Film Stars
Authors: Astrup Jannie Dahl
Published: May 2024

The wildly popular comic duo of the 1920s Pat and Patachon (Fyrtaarnet og Bivognen in Danish) brought international success to the Danish production company Palladium and director Lau Lauritzen. This chapter explains their popularity outside Denmark through an examination both of the various entanglements of business partners, production companies, film consortiums and the press discourse on Pat and Patachon in German-speaking countries. The chapter profiles key industry figures like Lothar Stark and Arthur G. Gregory, producers, distributors and transnational dealmakers. The chapter also analyses the eight films made in Germany and Austria by the duo.
The Land of Frankincense: Dhofari Sites as National and World Heritage
Authors: Lewis Krista
Published: May 2024

Frankincense is one of Oman’s most recognizable and celebrated cultural symbols. The modern rise in visibility of frankincense as a part of Omani identity and economy is closely tied to the history of archaeological research in Oman’s southern region of Dhofar. Over the course of Sultan Qaboos’ reign, the archaeological and cultural heritage of southern Oman, where frankincense trees grow, went from virtually unknown to a backbone of the Sultanate’s national identity and tourism industry due to strategic promotion of its association with frankincense.
From the First Renaissance to the Second: The Historical and Legal Basis for the Sultanate
Authors: al-Salimi Abdulrahman
Published: May 2024

Oman’s modern renaissance of 1970 was linked to the first Omani Renaissance of Ibadi thought in the nineteenth century. This earlier renaissance was when Oman’s Ibadi Sharia (Ibadi Islamic Law; see Chapter 6) was first modernized and adapted for a variety of contexts. It was also in this earlier period when Oman’s political system under the Imamate and the Sultanate ruled the country either concurrently or in rotation. There were several links between the traditions of the past and the character of the modern state. Those historic links paved the way for the emergence and evolution of modern Oman.
Nation and State in Oman: The Initial Impact of 1970
Authors: Peterson J. E.
Published: May 2024

The emergence and consolidation of the Omani state after 1970 can be explained by exploring basic concepts that define the country, nation, state, and government. This approach provides insights into the initial development of the post-1970 Sultanate under Sultan Qaboos. The first few years of the 1970s were pivotal, formative, and transitional. This was the time when Oman changed from being an undefined nation searching for a serviceable state to a new capable state elaborating a cohesive national identity.
Introduction: Linklater’s Itinerant Oeuvre
Authors: Wilkins Kim , Vermeulen Timotheus
Published: May 2024

This chapter introduces Linklater’s rich and varied body of work as well as extant scholarship on his films. It introduces the collection’s overarching considerations: Linklater’s ambiguous relationships to both Hollywood and the American independent film tradition, to the dominant cultural sensibility of the late twentieth century—postmodernism—and to corporate America and neoliberalism more generally; his tendency to switch genres; and his ostensibly unassuming stylistic register. It argues that what unites Linklater’s significant and eclectic filmography is a fundamental concern with, and for, America.
On Drifts and Swerves: Linklater’s Love for Lacunae
Authors: Boom Jeroen
Published: May 2024

Richard Linklater’s break-through film Slacker (1991) can be seen as a manifestation of topophilia. Its meandering camera drifts in an almost continuous motion through the urban fabric of Austin, Texas, eagerly traversing from one site to another, weaving together the lives of eccentric characters and the idiosyncratic worlds they inhabit. This chapter considers the film’s topophilia in the context of broader postmodern discourses, including Giuliana Bruno’s voyageuristic cartographies, Jean-François Lyotard’s discursive archipelago, and Gilles Deleuze’s unpredictable swerve. It emphasizes the figure of the topophilic swerve as a metaphor for Linklater’s oeuvre, which continually deviates from generic frameworks and categories.
Richard Linklater and the Field of American Dreams 1
Authors: Vermeulen Timotheus
Published: May 2024

This chapter considers the use of baseball in the oeuvre of Linklater. It is concerned specifically with the function of the game, its players and its culture in the director’s two sports genre movies Bad News Bears (2005) and Everybody Wants Some!! (2016); but takes into account its presentation in other films as well. Drawing on close textual analysis and social theory, the chapter argues that baseball—which Linklater himself played at college level before a heart problem ended his chances of going pro—is used to contemplate both the joys and the traumas of youthful, male and mostly white comradery in US Culture; and, conversely, to reflect on an American culture historically dominated by white old ‘boys’. Indeed, if baseball is frequently said to be a symbol of the American Dream (Grello, 1974), Linklater suggests it is a rather distinct and exclusive one.
Stories So Far: Romantic Comedy and/as Space in Before Midnight *
Authors: Deleyto Celestino
Published: May 2024

When Before Sunrise (1995) was released, the film was part of a series of independent romantic comedies appearing during the 1990s that offered a fresh perspective on a genre that had since the mid-1980s experienced a revival in the mainstream. As indie comedy expands into the 21st Century, Linklater released two sequels, Before Sunset (2004) and Before Midnight (2013), completing a three-part narrative that, in retrospect, evokes the gradual relocation of the genre first in TV series and then in streaming platform content, not the least in its increasing transnational dimension. This chapter considers this transnational dimension of the Before trilogy through a cosmopolitan lens and concepts such as cosmopolitan canopies, elite cosmopolitanism, borderwork, and messy cosmopolitanism. It analyzes the trilogy in relation to the manners in which intimate protocols in early 21st-century societies have been inflected by transnational culture.
PROFIL JUMLAH NEOVASKULARISASI LUKA MENCIT HIPERGLIKEMIK YANG DIBERIKAN GEL EKSTRAK BUAH OKRA (Abelmoschus esculentus L.)
Authors: Chandra Pra Panca Bayu , Lisnawati Nia , Susanti Yanthy
Published: May 2024

This study aimed to examine the gel activity of okra fruit extract (Abelmoschus esculentus L.) in mice with hyperglycemic conditions based on histopathological indicator parameters, namely the amount of neovascularization. Mus musculus strain male mice were hyperglycemic with STZ at a dose of 0.06 mg/gBW. Mice were divided into 8 groups (n=6). Group 1 (Non-DM Control), Group 2 (DM Control), Groups 3 to 8 (Test). The dose of glibenclamide was 5 mg/KgBW, the dose of okra fruit extract was 400 mg/KgBW and the dose of CMC Na was 5 mL/KgBW. Therapy was given once a day (oral and topical) for 15 days of therapy which was seen on days 0, 5, 11 and 15. The results of the study showed an increase in the number of neovascularizations on the 15th day of therapy in the test group compared to the control group. Administration of a combination of topical okra fruit extract gel with okra fruit extract orally for 15 days of therapy was able to increase the amount of neovascularization compared to administration without the combination or only orally. Administration of a combination of topical gel and oral okra fruit extract accelerated the wound healing process in hyperglycemic mice compared to non-combination administration. Management of fasting blood glucose levels has an effect on the success of the diabetic wound healing process.
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL BIJI BUAH NYIRIH (Xylocarpus granatum) DENGAN METODE DPPH SECARA SPEKTROFOTOMETRI UV-VIS
Authors: Mutmainna Tamrin  , Achmad Kadri Ansyori  , Hayatus Sa'adah
Published: May 2024

The nyirih plant (Xylocarpus granatum) is a type of mangrove that has been used for generations by coastal communities as traditional medicine. The flavonoid compounds contained in the nyirih plant are a group of polyphenols which have potential as antioxidants that can reduce free radicals. The aim of this research was to determine the antioxidant activity of ethanol extract of nyirih fruit seeds. The research carried out was non-experimental research, the stages of this research started from plant determination and sample collection, making simplicia, making extracts using the maceration method with 70% ethanol, phytochemical screening, and antioxidant activity testing using the DPPH method as free radicals which were measured using a spectrophotometer. UV-Vis. The research results obtained showed that the ethanol extract of nyirih fruit seeds positively contained secondary metabolites in the form of alkaloids, flavonoids, tannins and saponins. The results of the antioxidant activity test of the ethanol extract of nyirih fruit seeds obtained an IC50 value of 8.2729 ppm in the very strong antioxidant category.
The doer’s rush: contemplation is a designer lost skill
Authors: Pedroso-Roussado Cristiano
Published: May 2024

The desire of creative practices is now to make. By the one hand, artists, designers (and engineers) did too much, rushing the harmful crisis humans experience worldwide - there is the neglect of the thinking, the observing, the contemplating. Although we are witnessing a post-Bauhaus era in design and education, the effects of the Bauhaus school are still very present in design school agendas. However, the New European Bauhaus initiative as a solution to tackle global problems should be challenged since it may fall short for the post-colonialist and ecological feminism theories. Bacterial cellulose (BC) is a nanopolymer mainly produced by Komagateibacter spp. BC synthesis is slow and happens by the occurrence of a plethora of biochemical processes. Since all these biological processes occur at the nano and micrometer scale it is relevant to explore them with the naked eye, allowing the creative thinking to expand the comprehension throughout the act of contemplation and observation. This essay explores the materiality of BC production as materiality of contemplation. Therefore, the materiality here explored is not narrowed by any expected result or successful outcome originating from the scientific, artistic and design practice. The urge is no more to make and biodesigners might be the last hope for an ethical generation of practitioners.
Material beyond Materials. An interdisciplinary workshop for biodesigning
Authors: Marseglia Marco , Cantini Francesco , Celli Tommaso , Brunelli Edoardo , Lotti Giuseppe
Published: May 2024

The urgencies of the contemporary scenario impose on the world of design the need for complex responses; the dialogue with other disciplines becomes a fundamental planning source. In this sense, the necessity is to have an increasing need of designers capable of understanding and interacting with the hard sciences in a more conscious and complete way, in order to develop future application scenarios in every aspect of design, from materials to everyday products, up to new systemic scenarios. The contribution presents a 3CFU training experience carried out by the Design for Sustainability Laboratory (University of Florence) which had the aim of introducing students to Material Design and Biodesign. The applied methodology started from the concepts of Material Experience and Material Driven Design, including interdisciplinary skills in the design process from the early design stages. In particular, the students were led to experiment with "biotinkering" solutions with the mycelium - Pleurotus ostreatus - within a biosafety Level (BSL) 1 Lab, creating materials prototypes. In the training activities, students were provided with theoretical notions and resources relating to biology and the scientific method with the aim of combining Design and Life Sciences. From a methodological point of view, this knowledge served to provide future biodesigners with greater awareness of biotechnological processes and laboratory work. The originality and success of the Workshop consist in opening up new design horizons to future biodesigners thanks to a deep knowledge of natural processes and the possibility of consciously designing starting from the micro scale.
Pemberdayaan Pengemudi Bus Lb.Bulus-Tasikmalaya untuk Promosi Pariwisata Jawa Barat
Authors: Ngarbingan Hubertina Karolina , Suruyantari Yulita , Akbara Anisa Zahwa , Satyarini Ni Wayan Marsha , Lanisy Nihan Anindiyaputra , Mulyana Andy
Published: May 2024

West Java tourism has great potential to attract domestic and international tourists. Throughout 2022, 52.3 million domestic tourists will visit tourist attractions in West Java, while the number of foreign tourists will reach 146 thousand. The main attraction of West Java is its rich natural resources and traditional cultural heritage. The foundations of this culture are still felt strongly in the community, especially in their skills in making crafts and souvenirs, which are the main theme of this region. Therefore, bus drivers serving the route of Lb. Bulus-Tasikmalaya has great potential to promote West Java tourism. Interaction with many tourists from various regions and backgrounds, during a long journey that takes around 8-10 hours can be used as a golden opportunity to promote West Java tourism. One of them is by providing information about tourist destinations in West Java, such as natural, cultural, culinary, and historical tourist attractions. This PkM aims to empower Lb bus drivers. Bulus-Tasikmalaya to become an effective West Java tourism promotion agent. Data was collected through observation, interviews, and documentation. Observation results show that bus drivers have limited knowledge about West Java's tourism potential. Apart from that, bus drivers also do not have adequate tourism promotional materials. Based on the results of observations, it is recommended to empower bus drivers through training, providing tourism promotional materials, and providing incentives. By providing training, providing tourism promotion materials, and incentives, bus drivers experience increased knowledge and skills in promoting the tourism image of West Java, improve the quality of service and charity towards tourists, and increase tourist interest.
Pelatihan Accounting Games Sebagai Sarana Peningkatan Dasar Literasi Akuntansi Pada Generasi Milenial dan Zoomer
Authors: Prasetiyo Yudhi , Widiastuti Yeni , Wisnantiasri Sila Ninin , Paramitha Diky , Nugraheni Novita , Dwirini Dwirini , Zuhroh Shufia
Published: May 2024

The importance of learning about accounting knowledge from the start is the right step in preparing prospective accountants in the future. The importance of learning accounting using the game method has a good impact and response to the millennial generation in terms of increasing their financial literacy in carrying out economic activities. This training was carried out with the aim of increasing knowledge of accounting and financial literacy to prepare the millennial generation who are ready to become accountants in the future. This community service is carried out at Dharma Karya High School (SMA). The target audience for this training is grade 12 students with a concentration in social sciences. This training method is carried out offline using game accounting media as a tool for carrying out mentoring and training for class 12 students at SMA Dharma Karya. The results of this training were that Class 12 High School students with a concentration in social sciences were happier and were able to capture learning in the field of accounting to capture the absorption capacity related to accounting and financial literacy. Then in this training the participants' enthusiasm became higher and enthusiastic because the method used could make students' thinking about accounting easier and lighter, compared to learning using the text book method. With this training, overall participants can capture learning and increase accounting literacy more quickly and easily.
Asymmetric generalized error distribution with its properties and applications
Authors: Abebe Tayu Nigusie , Goshu Ayele Taye
Published: May 2024

The main finding of this study is the derivation of a new probability distribution that reveals interesting properties, especially with various asymmetry and kurtosis behavior. We call this distribution the asymmetric generalized error distribution (AGED). AGED is a new contribution to the field of statistical theory, offering more flexible probability density functions, cumulative distribution functions, and hazard functions than the base distribution. The AGED also includes normal, uniform, Laplace, asymmetric Laplace, and generalized error distribution (GED) as special cases. The mathematical and statistical features of the distribution are derived and discussed. Estimators of the parameters of the distribution are obtained using the maximum likelihood approach. In a simulation study, random samples are generated from the new probability distribution to illustrate what ideal data looks like. Using real data from diverse applications such as health, industry, and cybersecurity domains, the performance of the new distribution is compared to that of other distributions. The new distribution is found to be a better fit for the data, showing great adaptability in the context of real data analysis. We expect the distribution to be applied to many more real data, and the findings of the study can be used as a basis for future research in the field.
Causal rate-independent damping device using a rotary inerter damper
Authors: Wang Boxiong , Ikago Kohju , Kezuka Shotaro
Published: May 2024

The resistive force of linear viscous damping (LVD), which is commonly used as a damping model for structures, decreases proportionally with the frequency. Another linear damping model known as the rate-independent linear damping (RILD) model is used as a linear mathematical model for representing the damping characteristics of structures and materials that have a low frequency dependency. Because the resistive force of RILD is proportional to the displacement amplitude instead of the velocity, it is expected to directly and effectively control the seismic response displacement of low-frequency structures if implemented in a physical device. In this study, we propose the application of a causal approximation model of the RILD model—based on Biot’s model—that extends the order of dynamic stiffness of each branch to the second order with seismically isolated structures. A few branches of commercially available tuned viscous mass dampers with second-order dynamic stiffness are arranged in parallel in the proposed device. When the demand for isolator displacement mitigation is moderate, the proposed model simulates the performance of the RILD model well. The proposed system outperforms the LVD system even when the demand for isolator displacement mitigation becomes more severe.
Reanimating feminist archives: ethics and praxis
Authors: Webb Sharon , Thomson Rachel , Moore Niamh
Published: May 2024

This study explores the complexities of developing feminist archives with a particular focus on the ‘Feminist Approaches to Youth Sexuality (FAYS)’ archive, created as part of the Reanimating Data project (RAD, 2018-21). Through this case study, we explore the ethical considerations and practices involved in reanimating a landmark feminist study, the Women, Risk, and AIDS Project (WRAP), and emphasize the ethical dimensions of reanimation processes, considering feminist ethics of care and risk. We also explore the concept of rematriation, which is rooted in indigenous feminist scholarship. This concept has become a guiding principle in our efforts to return WRAP to its geo-political context. As such, the article is structured into the following three sections: data in the attic, on recovery and rematriation; feminist ethics, on care and risk; and feminist archival praxis, on reanimating and language.
Clinical outcomes and aortic remodeling after Castor single-branched stent-graft implantation for type B aortic dissections involving left subclavian artery
Authors: Yuan Zihui , Zhang Lihua , Cai Fei , Wang Jian
Published: May 2024

Background

The left subclavian artery (LSA) can be intentionally covered by a stent graft to acquire adequate landing zones for a proximal entry tear near the LSA during thoracic endovascular aortic repair (TEVAR). The Castor single-branched stent graft is designed to treat type B aortic dissection (TBAD) to retain the LSA during TEVAR. This study investigates clinical outcomes, aortic remodeling, and abdominal aortic perfusion patterns after TEVAR with the novel Castor device.

Methods

From November 2020 to June 2023, 29 patients with TBAD involving the LSA were treated with the Castor single-branched stent graft. In-hospital clinical outcome and aortic computed tomography angiography (CTA) data were analyzed. CTA was performed preoperatively and at follow-up to observe stent morphology; branch patency; endoleak; change in true lumen (TL), false lumen (FL), and transaortic diameters; and abdominal aortic branch perfusion pattern.

Results

The technical success rate was 96.6%. One failure was that the branch section did not completely enter the LSA and the main body migrated distally. No in-hospital mortality, paraplegia, or stroke occurred. During follow-up, one type Ib endoleak, four distal new entry tears, and one recurrent type A dissection arose from a new entry tear at the ascending aorta, no stent migration was observed, and the branch patency rate was 100%. At the thoracic aorta, TL diameters significantly increased, FL diameters markedly decreased, and FL was partially or completely thrombosed in most patients at follow-up. At the abdominal aorta, we observed 33.3% of TL growth and 66.7% of TL stabilization or shrinkage. The initial TL ratio at iliac bifurcation negatively predicted abdominal TL growth after TEVAR with a cutoff of 21.0%. Of the 102 abdominal aortic branches, 94.1% of the branches showed no change in perfusion pattern, 3.9% of the branches had an increased TL perfusion, and 2.0% of the branches had an increased FL contribution.

Conclusion

The Castor unibody single-branched stent graft offers an efficient endovascular treatment for TBAD involving the LSA. TEVAR with the Castor device effectively induced thoracic FL thrombosis and thoracic TL enlargement and resulted in abdominal TL growth when the initial TL ratio at iliac bifurcation is less than 21.0%. Abdominal aortic branch perfusion patterns remain relatively stable after TEVAR with the Castor stent graft.
Mechanisms of left ventricular systolic dysfunction in light chain amyloidosis: a multiparametric cardiac MRI study
Authors: Katznelson Ethan , Jerosch-Herold Michael , Cuddy Sarah A. M. , Clerc Olivier F. , Benz Dominik C. , Taylor Alexandra , Rao Shivani , Kijewski Marie Foley , Liao Ronglih , Landau Heather , Yee Andrew J. , Ruberg Frederick L. , Di Carli Marcelo F. , Falk Rodney H. , Kwong Raymond Y. , Dorbala Sharmila
Published: May 2024

Background

Cardiac systolic dysfunction is a poor prognostic marker in light-chain (AL) cardiomyopathy, a primary interstitial disorder; however, its pathogenesis is poorly understood.

Purpose

This study aims to analyze the effects of extracellular volume (ECV) expansion, a surrogate marker of amyloid burden on myocardial blood flow (MBF), myocardial work efficiency (MWE), and left ventricular (LV) systolic dysfunction in AL amyloidosis.

Methods

Subjects with biopsy-proven AL amyloidosis were prospectively enrolled (April 2016–June 2021; Clinicaltrials.gov ID NCT02641145) and underwent cardiac magnetic resonance imaging (MRI) to quantify rest MBF by perfusion imaging, LV ejection fraction (LVEF) by cine MRI, and ECV by pre- and post-contrast T1 mapping. The MWE was estimated as external cardiac work from the stroke volume and mean arterial pressure normalized to the LV myocardial mass.

Results

Rest MBF in 92 subjects (62 ± 8 years, 52 men) with AL amyloidosis averaged 0.87 ± 0.21 ml/min/g and correlated with MWE (r = 0.42; p < 0.001). Rest MBF was similarly low in subjects with sustained hematologic remission after successful AL amyloidosis therapy (n = 21), as in those with recently diagnosed AL amyloidosis. Both MBF and MWE decreased by ECV tertile (p < 0.01 for linear trends). The association of ECV with MWE comprised a direct effect (84% of the total effect; p < 0.001) on MWE from adverse interstitial remodeling assessed by ECV and an indirect effect (16% of the total effect; p < 0.001) mediated by MBF. There was a significant base-to-apex gradient of rest MBF in subjects with higher amyloid burden.

Conclusions

In AL amyloidosis, both MBF and MWE decrease as cardiac amyloid burden and ECV expansion increase. Both structural and vascular changes from ECV expansion and myocardial amyloid burden appear to contribute to lower MWE.
Right ventricular fibrosis in adults with uncorrected secundum atrial septal defect and pulmonary hypertension: a cardiovascular magnetic resonance study with late gadolinium enhancement, native T1 and extracellular volume
Authors: Ginting Munte Fatwiadi Apulita , Elen Elen , Lelya Olfi , Rudiktyo Estu , Prakoso Radityo , Lilyasari Oktavia
Published: May 2024

Introduction

Right ventricular (RV) fibrosis represents both adaptive and maladaptive responses to the overloaded RV condition. Its role in pulmonary hypertension (PH) associated with secundum atrial septal defect (ASD), which is the most common adult congenital heart disease (CHD), remains poorly understood.

Methods

We enrolled 65 participants aged ≥18 years old with uncorrected secundum ASD who had undergone clinically indicated right heart catheterization (RHC), divided into the non-PH group (n = 7), PH group (n = 42), and Eisenmenger syndrome (ES) group (n = 16). We conducted cardiovascular magnetic resonance (CMR) studies with late gadolinium enhancement (LGE) imaging, native T1 mapping, and extracellular volume (ECV) measurement to evaluate the extent and clinical correlates of RV fibrosis.

Results

LGE was present in 94% of the population and 86% of the non-PH group, mostly located at the right ventricular insertion point (RVIP) regions. LGE in the septal and inferior RV region was predominantly observed in the ES group compared to the other groups (p = 0.031 and p < 0.001, respectively). The mean LGE scores in the ES and PH groups were significantly higher than those in the non-PH group (3.38 ± 0.96 vs. 2.74 ± 1.04 vs. 1.57 ± 0.79; p = 0.001). The ES and PH groups had significantly higher degrees of interstitial RV fibrosis compared to those in the non-PH group, indicated by native T1 (1,199.9 ± 68.9 ms vs. 1,131.4 ± 47.8 ms vs. 1,105.4 ± 44.0 ms; p < 0.001) and ECV (43.6 ± 6.6% vs. 39.5 ± 4.9% vs. 39.4 ± 5.8%; p = 0.037). Additionally, native T1 significantly correlated with pulmonary vascular resistance (r = 0.708, p < 0.001), RV ejection fraction (r = −0.468, p < 0.001) and peripheral oxygen saturation (r = −0.410, p = 0.001).

Conclusion

In patients with uncorrected secundum ASD, RV fibrosis may occur before the development of PH and progressively intensify alongside the progression of PH severity. A higher degree of RV fibrosis, derived from CMR imaging, correlates with worse hemodynamics, RV dysfunction, and poorer clinical conditions.
Analyzing political party positions through multi-language twitter text embeddings
Authors: Chen Jinghui , Mizuno Takayuki , Doi Shohei
Published: May 2024

Traditional monolingual word embedding models transform words into high-dimensional vectors which represent semantics relations between words as relationships between vectors in the high-dimensional space. They serve as productive tools to interpret multifarious aspects of the social world in social science research. Building on the previous research which interprets multifaceted meanings of words by projecting them onto word-level dimensions defined by differences between antonyms, we extend the architecture of establishing word-level cultural dimensions to the sentence level and adopt a Language-agnostic BERT model (LaBSE) to detect position similarities in a multi-language environment. We assess the efficacy of our sentence-level methodology using Twitter data from US politicians, comparing it to the traditional word-level embedding model. We also adopt Latent Dirichlet Allocation (LDA) to investigate detailed topics in these tweets and interpret politicians' positions from different angles. In addition, we adopt Twitter data from Spanish politicians and visualize their positions in a multi-language space to analyze position similarities across countries. The results show that our sentence-level methodology outperform traditional word-level model. We also demonstrate that our methodology is effective dealing with fine-sorted themes from the result that political positions towards different topics vary even within the same politicians. Through verification using American and Spanish political datasets, we find that the positioning of American and Spanish politicians on our defined liberal-conservative axis aligns with social common sense, political news, and previous research. Our architecture improves the standard word-level methodology and can be considered as a useful architecture for sentence-level applications in the future.
Personal and social facilitators of student engagement: transition into higher education
Authors: Vardal-Ocakli Sermin , Ok Ahmet
Published: May 2024

Facilitating student engagement at all levels of higher education is critical, but since transition-year experiences pave the way for further engagement, it requires more attention. Considering its significance and impact on students’ life–changing decisions and attitudes, this study was designed with a major focus on the personal and social facilitators of engagement. It was conducted with 165 university students, who were both language learners and the transition- year students. In line with a theoretical model, how well personal facilitators would predict the performance of transition-year students and what expectations these students held concerning social facilitators were questioned. The former investigation required the correlational method, whereas the descriptive survey method was preferred for the latter one. The results of analyses indicated that the theory partly validated the significance of personal facilitators, whereas it provided evidence for the facilitative role of social facilitators for transitional year student engagement. Therefore, it was concluded that the more responsive the schools and teachers are to student needs, the more likely students feel engaged.
Development of a predictive nomogram for intermediate-risk differentiated thyroid cancer patients after fixed 3.7GBq (100mCi) radioiodine remnant ablation
Authors: Lu Lu , Li Qiang , Ge Zhao , Lu Yanqi , Lin Chunhao , Lv Jinfu , Huang Jinquan , Mu Xingyu , Fu Wei
Published: May 2024

Objectives

The objective of this study was to develop a predictive nomogram for intermediate-risk differentiated thyroid cancer (DTC) patients after fixed 3.7GBq (100mCi) radioiodine remnant ablation (RRA).

Methods

Data from 265 patients who underwent total thyroidectomy with central lymph node dissection (CND) and received RRA treatment at a single institution between January 2018 and March 2023 were analyzed. Patients with certain exclusion criteria were excluded. Univariate and multivariate logistic regression analyses were performed to identify risk factors for a non-excellent response (non-ER) to RRA. A nomogram was developed based on the risk factors, and its performance was validated using the Bootstrap method with 1,000 resamplings. A web-based dynamic calculator was developed for convenient application of the nomogram.

Results

The study included 265 patients with intermediate-risk DTC. Significant differences were found between the ER group and the non-ER group in terms of CLNM>5, Hashimoto’s thyroiditis, sTg level, TgAb level (P < 0.05). CLNM>5 and sTg level were identified as independent risk factors for non-ER in multivariate analysis. The nomogram showed high accuracy, with an area under the curve (AUC) of 0.833 (95% CI = 0.770–0.895). The nomogram’s predicted probabilities aligned closely with actual clinical outcomes.

Conclusions

This study developed a predictive nomogram for intermediate-risk DTC patients after fixed 3.7GBq (100mCi) RRA. The nomogram incorporates CLNM>5 and sTg levels as risk factors for a non-ER response to RRA. The nomogram and web-based calculator can assist in treatment decision-making and improve the precision of prognosis information. Further research and validation are needed.
Clinical characteristics and long-term management for patients with vitamin D-dependent rickets type II: a retrospective study at a single center in Saudi Arabia
Authors: Alsagheir Afaf , Al-Ashwal Abdullah , Binladen Amal , Alhuthil Raghad , Joueidi Faisal , Ramzan Khushnooda , Imtiaz Faiqa
Published: May 2024

Introduction

Hereditary Vitamin D-dependent rickets type II (HVDDR-type II) is a rare autosomal recessive disorder caused by molecular variation in the gene encoding the vitamin D receptor (VDR). This study aims to evaluate phenotype and genotype characteristics and long-term follow-up of the largest group of patients with (HVDDR-type II) in Saudi Arabia.

Methodology

We conducted a retrospective chart review to collect the clinical, biochemical, and genetic data for all HVDDR-type II patients currently receiving treatment at King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.

Results

A total of 42 patients, 57.1% female, and 42.9% male were included in the study. Seven patients were treated with high doses of oral calcium, while 35 patients were treated with IV calcium infusion. The median age at presentation was 15.5 months. Alopecia was found in 97.6%, 21.4% presented with bowing legs, 14.3% with delayed walking, 9.5% with seizure, and 2.4% presented with respiratory failure, while a family history of the disease was positive in 71.4% of total patients. Molecular genetic testing of the VDR gene in our cohort identified six different gene variants c.885 C>A (p.Tyr295Ter), c.88 C>T (p.Arg30Ter), c.1036G>A (p.Val346Met), c.820C>T (p.Arg274Cys), c.803 T>C (p.Ile268Thr), and c.2T>G (p.Met1?).

Conclusion

We are describing the largest cohort of patients with HVDDR-type II, their clinical biochemical findings, and the most prevalent genetic variants in our population.
Insulin-like growth factor family and prostate cancer: new insights and emerging opportunities
Authors: Elemam Noha M. , Hotait Hassan Youssef , Saleh Mohamed A. , El-Huneidi Waseem , Talaat Iman M.
Published: May 2024

Prostate cancer is the second most commonly diagnosed cancer in men. The mammalian insulin-like growth factor (IGF) family is made up of three ligands (IGF-I, IGF-II, and insulin), three receptors (IGF-I receptor (IGF-1R), insulin receptor (IR), and IGF-II receptor (IGF-2R)), and six IGF-binding proteins (IGFBPs). IGF-I and IGF-II were identified as potent mitogens and were previously associated with an increased risk of cancer development including prostate cancer. Several reports showed controversy about the expression of the IGF family and their connection to prostate cancer risk due to the high degree of heterogeneity among prostate tumors, sampling bias, and evaluation techniques. Despite that, it is clear that several IGF family members play a role in prostate cancer development, metastasis, and androgen-independent progression. In this review, we aim to expand our understanding of prostate tumorigenesis and regulation through the IGF system. Further understanding of the role of IGF signaling in PCa shows promise and needs to be considered in the context of a comprehensive treatment strategy.