bluuebunny/crossref_metadata_2025 huggingface dataset:
STRATEGI PENGEMBANGAN USAHA OUTDOOR GEAR DALAM MENINGKATKAN PENDAPATAN PERUSAHAAN PADA TOKO OUTDOOR GEAR DI KECAMATAN TULUNGAGUNG KABUPATEN TULUNGAGUNG
Authors: Arifah Robiah Al Addawiyah
Published: May 2024

ABSTRAK
Outdoor gear merupakan pelengkap para traveller yang hendak menikmati alam. Banyaknya toko outdoor gear yang berada di Kecamatan Tulungagung Kabupaten Tulungagung, namun tidak semua toko outdoor gear menyediakan fasilitas berupa penyewaan. Sehingga dengan hal tersebut dengan adanya toko outdoor gear seperti toko Basecamp Outdoor Gear dan Nepali Outdoor Gear dapat memfasilitasi traveller yang ingin menyewa. Dalam hal ini strategi baiknya diperhatikan karena kian lama akan banyaknya competitor. Sehingga dengan adanya penelitian ini bertujuan untuk mengetahui strategi pengembangan usaha dalam meningkatkan pendapatan perusahaan. Penelitian yang digunakan yakni penelitian kualitatif dengan reduksi data, penyajian data, penarikan kesimpulan dan verifikasi. Adapun hasil dari penelitian yakni masing-masing dari toko outdoor gear memiliki cara dalam melaksanakan perluasan skala ekonomi , perluasan cakupan usaha dan melakukan kegiatan promosi yang mana dengan melakukan stratengi pengembangan tersebut masing-masing toko outdoor gear dapat bertahan dari semakin banyaknya competitor yang berdatangan dan meningkatkan pendapatan perusahaan.
Exploring the Role of Accounting Practices and Financial Analysis: A Case Study in Perfect Zone Buraidah
Authors: Maspul Kurniawan Arif , Akrem Ahmed Mohammed
Published: May 2024

This compelling case study delves into the critical role of accounting techniques and financial analysis in business management. The study explores the obstacles faced and the tactics used to overcome them by drawing on the firsthand experiences of an accountant at a startup business. The study emphasizes the importance of precise inventory management, budgeting and forecasting, financial monitoring, and sales performance analysis in attaining long-term growth and profitability. The findings emphasize the significance of combining accounting theories and practices in order to make informed decisions and achieve financial success. The study continues by underlining the importance of continuous financial planning and adaption in order to support long-term corporate growth.
Pengaruh Electronic Word Of Mouth (E-WOM) dan Top Of Mind Terhadap Keputusan Pembelian di Restoran Seblak Mantan Jombang
Authors: Faidatul Kamiliya
Published: May 2024

Penelitian ini bertujuan untuk menguji pengaruh secara parsial Electronic Word Of Mouth (E-WOM) dan Top Of Mind terhadap keputusan pembelian di Restoran seblak mantan Jombang, dan untuk menguji Pengaruh secara simultan Electronic Word Of Mouth (E-WOM) dan Top Of Mind TerhadapKeputusan Pembelian di Restoran Seblak Mantan Jombang. Pendekatan dalam penelitian ini adalah kuantitatif dengan jenis asosiatif kausal. Populasi penelitian ini adalah pelanggan yang pernah membeli di restoran seblak mantan Jombang, dengan pemilihan sampling nonprobability sampling yaitu dengan kriteria responden yang mempunyai media sosial aktif. Dengan teknik pengambilan sampel purposive sampling. Jumlah sampel sebanyak 100 responden yang diperoleh dengan menggunakan rumus lemeshow. Teknik pengumpulan data dalam penelitian ini menggunakan kuesioner yang disebar secara langsung menggunakan link barcode dan secara tidak langsung disebar secara online. Pengolahan data dalam penelitian ini dengan menggunakan SPSS versi 22.0. Selain itu penelitian ini dilakukan uji validitas, uji reliabilitas, uji asumsi klasik, uji regresi berganda, uji hipotesis, dan uji koefisien determinasi. Hasil penelitian ini yaitu Electronic Word Of Mouth (EWOM) berpengaruh secara positif dan signifikan terhadap keputusan pembelian di Restoran SeblakMantan Jombang 0,000 < 0,05 dan t hitung 8,643 > t tabel 1,998. Top Of Mind berpengaruh positif dan signifikan terhadap keputusan pembelian dengan sig 0,000 > 0,05 dan t hitung 5,988 > t tabel 1,988, dan Electronic Word Of Mouth (E-WOM) dan Top Of Mind berpengaruh positif dan signifikan terhadap keputusan pembelian di Restoran Seblak Mantan Jombang dengan nilai sig sebesar 0,000 < 0,05 dan F hitung 227,502 > F tabel 3,09.
Analisis Efektivitas Pengelolaan Dana Zakat Produktif Dalam Upaya Pengentasan Kemiskinan Pada Badan Amil Zakat Nasional(BAZNAS) Kabupaten Tulungagung
Authors: Putri Wahyuning Tyas
Published: May 2024

Penelitian ini dilatarbelakangi oleh Badan Amil Zakat Nasional (BAZNAS) Kabupaten Tulungagung yang kini dipercayai melaksanakan pengelolaan dana zakat secara professional. Sehingga, kesadaran masyarakat dapat menjadi pendorong utama untuk meningkatkan kesejahteraan masyarakat secara keseluruhan. Tujuan penelitian ini adalah: 1) Untuk mengetahui pengelolaan dana zakat produktif dalam upaya pengentasan kemiskinan  pada  Badan Amil Zakat Nasional (BAZNAS)  Kabupaten Tulungagung. 2) Untuk mengetahui sejauh mana keefektivitas pengelolaan dana zakat produktif dalam upaya pengentasan kemiskinan  pada Badan Amil Zakat Nasional (BAZNAS)  Kabupaten Tulungagung. Penelitia ini merupakan penelitian lapangan dengan pendekatan kualitatif, dimana peneliti akan mendiskripsikan tentang analisis pengelolaan dana zakat produktif melalui bantuan  modal usaha untuk meningkatkan ekonomi masyarakat. Teknik pengumpulan data diperoleh dai observasi, dokumentasi, dan wawancara mendalam. Pengecekan keabsahan data menggunakan Teknik triangulasi sumber dan metode. Hasil penelitian ini menunjukkan bahwa: 1) Pengelolaan dana zakat produktif dalam upaya pengentasan kemiskinan  pada  Badan Amil Zakat Nasional (BAZNAS)  Kabupaten Tulungagung Dalam mengelola dana zakat produktif, Badan Amil Zakat Nasional Kabupaten Tulungagung mula-mula mengumpulkan dana tersebut dari para donatur yang akan dikumpulkan menjadi satu terlebih dahulu. Kemudian, dana tersebut nantinya akan disalurkan sesuai dengan program-program yang ada, terutama pada bantuan modal usaha. 2) Keefektivitas pengelolaan dana zakat produktif dalam upaya pengentasan kemiskinan  pada Badan Amil Zakat Nasional (BAZNAS)  Kabupaten Tulungagung. Usah-usaha yang dilakukan Badan Amil Zakat Nasional Kabupatn Tulungagung dalam membantu mustahik tersebut bisa dikatakan sudah efektif. Dilihat dari usaha yang dilakukan oleh Badan Amil Zakat Nasional (BAZNAS) Kabupaten Tulungagung yang selalu berusaha memaksimalkan dan menyalurkan dana zakata untuk kesejahteraan masyarakat.
Narrative Analysis: Demonstrating the Iterative Process for New Researchers
Authors: Bright Charmaine , Du Preez Elizabeth
Published: May 2024

This article demonstrates and describes an iterative process of narrative analysis for researchers who want to familiarise themselves with this methodology. The method draws on the six-step process of how to analyse a narrative, the four modes of reading a narrative and the three-sphere model of external context. The application of the method is demonstrated through describing the process of analysis of New Zealand school counsellors’ narratives of strengths-based counselling. Furthermore, this article posits that committing to a narrative analysis process of repeated and in-depth engagement with participants’ narrative data may facilitate a more robust and engaging research outcome than may otherwise have been achieved through more prescriptive methods of narrative analysis. Finally, this article highlights the use of story-map grids (tables) and models as visual aids to assist in the process of narrative analysis.
Drill Hall or Ball Hall? On Pedagogical Implications of the Old Age Motif in Katherine Mansfield’s Short Story “Her First Ball”
Authors: Gładkowska Eliza , Kwiatkowska Anna
Published: May 2024

This article uses the short story, “Her First Ball,” by Katherine Mansfield to demonstrate how fiction could be an effective tool in the process of deconstructing and transforming the master narrative of old age among secondary students of English as secondary language (ESL). The story not only offers some language points to focus on and some reading skills to develop, but it also provokes some pertinent questions about the image and meaning of old age. Aging themes in “Her First Ball” could serve as an excellent starting point for discussion among adolescent learners about old age. Moreover, such an open-ended approach to Mansfield’s story could potentially lead to a deepened awareness of the social impact of the semantics of old age as well as the transformation of students’ conceptualization of becoming mature and growing old. In addition, this article is devoted to rebuke such a purely didactic approach by presenting the literary text as a tool for complex pedagogical practices.
Human Energy Harvester as a Practical Source for Electronic Devices
Authors:   , Gorņevs Ilgvars
Published: May 2024

In the Doctoral Thesis, the generation of electrical energy from involuntary human movements, known as energy harvesting, is researched. The Thesis studies the individual components of the implementable power source based on their mutual compatibility. The insights and results of the research are practically combined to improve the performance of the created low-power source and evaluate it experimentally in realistic conditions. For that, an environmental parameters measurement system has been created, which adjusts consumption to adapt to the variable energy availability.
Društvenopolitičke implikacije etnokonfesionalizma – primjer Bosne i Hercegovine
Authors: Trninić Duško
Published: May 2024

Savremeni religijski trendovi obično govore o individualizaciji i privatizaciji religijskih osjećanja, što je najčešće izraženo kroz maksimu vjerovanja bez pripadanja (Davie, 1990), dok je u Bosni i Hercegovini obrnuta situacija. U posljednjoj deceniji prošlog i početkom 21. vijeka svjedočimo oživljavanju i revitalizaciji religije, kao i usponu kolektivističke religije i religioznosti. Visoka stopa religijske i konfesionalne identifikacije, kojoj smo svjedočili na popisima stanovništva 1991. i 2013. godine, nije bila motivisana jedino vjerskim već prije društvenim, istorijskim, političkim i kulturološkim razlozima, koji su pratili tok društvenih kretanja i promjena. Religijska pripadnost, koja je ranije, tokom socijalističkog društvenopolitičkog uređenja, bila duboko u privatnoj sferi življenja, sad postaje društveno poželjna, a religijska identifikacija bitna identitetska odrednica. Religijsko se tako potvrđuje kroz nacionalno i obrnuto – nacionalnost biva neraskidivo vezana za religijsku pripadnost i time postaje smetnja integraciji i demokratizaciji. Teorijskom analizom i sintezom dosadašnjih istraživanja, novijih trendova u sociološkom proučavanju religije, nastoji se sagledati religijska situacija u bh. društvu, koja se iskazuje od obnove i povratka religije u javni prostor do njezinih ideoloških manifestacija. Navedeni pristup religijskom značajan je iz bar dva razloga: teorijski ‒ jer korespondiraju sa zaokretom u savremenoj sociologiji religije, koji je usmjeren prema odgovoru na pitanje kako, nasuprot ranijem – zašto se vjeruje; dok sa druge strane, možda i važnije, ako pravilno sagledamo odnose u Bosni i Hercegovini, imamo društvenopolitičke razloge, gdje nam ponuđeni odgovori bitno mogu pomoći u rješavanju odnosa crkve i države, odnosno jasnog određivanja mjesta religije u javnom životu i njene uloge u savremenim društvenopolitičkim kretanjima i promjenama.
Утицај религије на обликовање српског националног идентитета у Босни и Херцеговини
Authors: Милошевић Боривоје
Published: May 2024

Национални идентитет обликују многи чиниоци, међу којима су најважнији језик, писмо, државно-правна традиција и религија. Многи аутори наглашавају превагу вjерског у лепези осталих идентитетских карактеристика балканских народа, па тако и српског. Период османске владавине од кључног је значаја за разумијевање међуетничких односа у Босни и Херцеговини. Тај простор је уз дијелове албанског, македонског и бугарског територија најдубље исламизован у односу на остале од стране Турака освојене дијелове европског континента. Исламизација је условила постепени продор исламске културе и обичаја у Босни и Херцеговини. Геополитички положај покрајина, на границама великих цивилизација и култура, потом и двије империје, османске и аустроугарске, додатно је утицао на усложњавање вјерских прилика и утицај религије на формирање модерних националних идентитета. Национална и вјерска сегментираност друштва у Босни и Херцеговини оставила је дубок траг и унутар политичког организовања, што можемо пратити још од почетка XX вијека када су током аустроугарске управе основане најраније политичке странке. Ратови који су кроз цијели XX вијек пустошили простор Босне и Херцеговине носили су у себи наглашено вјерско обиљежје.
Cult of Saint Sava and preservation of identity of Serbs in Bosnia during Ottoman and Austro-Hungarian administrations
Authors: Бранковић Бошко М.
Published: May 2024

The paper will elaborate on the cult of Saint Sava and its scope in Bosnia during the Ottoman and Austro-Hungarian administrations. The cult of Saint Sava was widely spread among the Serbian people in Bosnia during the Ottoman and Austro-Hungarian administrations. Such a great influence of the cult of Saint Sava in Bosnia is not accidental, if one takes into account the number of Serbian Orthodox people in Bosnia at that time. The affiliation of Serbs to the Orthodox faith and the Serbian Orthodox Church in Bosnia is unquestionable throughout history, and national and religious affiliations were especially expressed during the Ottoman and Austro-Hungarian administrations and the struggle to preserve national and religious identity. Migrations of the Serbian people also contributed to the spread of the cult to a significant extent, and wherever they migrated during the centuries of foreign rule, they carried with them the memory of the holy lineage of the Nemanjić dynasty, and the cult of Saint Sava, which at the beginning spread as a church cult, and later as a people’s cult. Therefore, it can be concluded that during the period of foreign rule, Ottoman and Austro-Hungarian, there was no person in Bosnia who did not know about the medieval dynasty of Nemanjić and Saint Sava.
Neuroscientist who does not feel pain: Subjective ontology and the perspective anamorphosis of consciousness
Authors: Jurić Andrija
Published: May 2024

Would the neuroscientist who does not feel pain know what he is studying? In this paper, the author analyzes the subjective ontology of conscious mental states and its origin – the subject’s first-person perspective. The ontology of the mental is irreducibly first-person ontology. In the thought experiment with neuroscientist Peter, it will be shown that a comprehensive science of consciousness requires a combined approach, as the phenomena of neuroscience are internally defined. The asymmetry between first-person and third-person perspectives regarding mental states will be strongly emphasized. The third part of the paper will offer a perspectival approach to the hard problem of consciousness. In conclusion, a truly objective science of subjectivity, a genuine science of consciousness, would have to engage scientifically with the subject’s egocentric first-person perspective.
Kажњавање насиља над женама (и дјецом) у Салијском закону у контексту кривичних одредаба четири члана закона (осврт на чланове XIII, XX, XXIV и XXV)
Authors: Костадиновић-Рачић Александра
Published: May 2024

У раду ће бити ријечи о казнама у Салијском закону које су биле предвиђене у случају да се догоди насиље над нејаким особама, првенствено, женама (и дјецом). Сходно томе, анализираћемо четири члана овога Закона – XIII, XX, XXIV и XXV, на основу чега ћемо указати да је он неријетко био на страни жена (и дјеце), гледајући их више као жртве, што је довело до тога да су новчане казне за убиство дјетета, силовање, отмицу или повреду жене биле далеко више, него за неке друге деликте. Битно је нагласити да би тадашње преступе, али и казне које су биле предвиђене за њих, када говоримо о горе наведеним категоријама становништва, требало посматрати у духу тога времена. Међутим, гледајући из данашњег угла, како су живјели људи у раном средњем вијеку, да се закључити да су се „варварски“ народи, у својим законима, са бројним деликтима често сурово „обрачунавали“. Казне које су прописиване за „прекршаје“, на које ћемо указати у раду, биле су, углавном, новчане и тјелесне, али у неким случајевима преступник је могао бити кажњен и смртном казном. Сврха свих ових казни била је у томе да се оштећеном лицу намири штета, губитак или бол, те да се починилац деликта прописно казни, али ту, већ, видимо сталешку неједнакост становништва. Тачније, примјетно је да су се за исти преступ различито кажњавали слободни, за разлику од неслободних људи, а уочава се, такође, и несразмјерност између прописане казне и кривичног дјела. Осим тога, поставља се питање колико су, уопште, германска племена поштовала своје законе, тачније да ли су се они дословно примјењивали.
Glycan-shielded homodimer structure and dynamical features of the canine distemper virus hemagglutinin relevant for viral entry and efficient vaccination
Authors: Fukuhara Hideo , Yumoto Kohei , Sako Miyuki , Kajikawa Mizuho , Ose Toyoyuki , Kawamura Mihiro , Yoda Mei , Chen Surui , Ito Yuri , Takeda Shin , Mwaba Mwila Hilton , Wang Jiaqi , Hashiguchi Takao , Kamishikiryo Jun , Maita Nobuo , Kitatsuji Chihiro , Takeda Makoto , Kuroki Kimiko , Maenaka Katsumi
Published: May 2024

Canine distemper virus (CDV) belongs to morbillivirus, including measles virus (MeV) and rinderpest virus, which causes serious immunological and neurological disorders in carnivores, including dogs and rhesus monkeys, as recently reported, but their vaccines are highly effective. The attachment glycoprotein hemagglutinin (CDV-H) at the CDV surface utilizes signaling lymphocyte activation molecule (SLAM) and Nectin-4 (also called poliovirus-receptor-like-4; PVRL4) as entry receptors. Although fusion models have been proposed, the molecular mechanism of morbillivirus fusion entry is poorly understood. Here, we determined the crystal structure of the globular head domain of CDV-H vaccine strain at 3.2 Å resolution, revealing that CDV-H exhibits a highly tilted homodimeric form with a six-bladed β-propeller fold. While the predicted Nectin-4 binding site is well-conserved with that of MeV-H, that of SLAM is similar but partially different, which is expected to contribute to host specificity. Five N-linked sugars covered a broad area of the CDV-H surface to expose receptor binding sites only, supporting the effective production of neutralizing antibodies. These features are common to MeV-H, although the glycosylation sites are completely different. Furthermore, real-time observation using high-speed atomic force microscopy revealed highly mobile features of the CDV-H dimeric head via the connector region. These results suggest that sugar-shielded tilted-homodimeric structure and dynamic conformational changes are common characteristics of morbilliviruses and ensure effective fusion entry and vaccination.
A high-throughput platform for single-molecule tracking identifies drug interaction and cellular mechanisms
Authors: McSwiggen David T. , Liu Helen , Tan Ruensern , Puig Sebastia Agramunt , Akella Lakshmi B. , Berman Russell , Bretan Mason , Chen Hanzhe , Darzacq Xavier , Ford Kelsey , Godbey Ruth , Gonzalez Eric , Hanuka Adi , Heckert Alec , Ho Jaclyn J. , Johnson Stephanie L. , Kelso Reed , Klammer Aaron , Krishnamurthy Ruchira , Li Jifu , Lin Kevin , Margolin Brian , McNamara Patrick , Meyer Laurence , Pierce Sarah E. , Sule Akshay , Stashko Connor , Tang Yangzhong , Anderson Daniel J. , Beck Hilary P.
Published: May 2024

The regulation of cell physiology depends largely upon interactions of functionally distinct proteins and cellular components. These interactions may be transient or long-lived, but often affect protein motion. Measurement of protein dynamics within a cellular environment, particularly while perturbing protein function with small molecules, may enable dissection of key interactions and facilitate drug discovery; however, current approaches are limited by throughput with respect to data acquisition and analysis. As a result, studies using super-resolution imaging are typically drawing conclusions from tens of cells and a few experimental conditions tested. We addressed these limitations by developing a high-throughput single-molecule tracking (htSMT) platform for pharmacologic dissection of protein dynamics in living cells at an unprecedented scale (capable of imaging > 10
6
cells/day and screening > 10
4
compounds). We applied htSMT to measure the cellular dynamics of fluorescently tagged estrogen receptor (ER) and screened a diverse library to identify small molecules that perturbed ER function in real time. With this one experimental modality, we determined the potency, pathway selectivity, target engagement, and mechanism of action for identified hits. Kinetic htSMT experiments were capable of distinguishing between on-target and on-pathway modulators of ER signaling. Integrated pathway analysis recapitulated the network of known ER interaction partners and suggested potentially novel, kinase-mediated regulatory mechanisms. The sensitivity of htSMT revealed a new correlation between ER dynamics and the ability of ER antagonists to suppress cancer cell growth. Therefore, measuring protein motion at scale is a powerful method to investigate dynamic interactions among proteins and may facilitate the identification and characterization of novel therapeutics.
Compositional editing of extracellular matrices by CRISPR/Cas9 engineering of human mesenchymal stem cell lines
Authors: Prithiviraj Sujeethkumar , Garcia Alejandro Garcia , Linderfalk Karin , Yiguang Bai , Ferveur Sonia , Falck Ludvig Nilsén , Subramaniam Agatheeswaran , Mohlin Sofie , Hidalgo David , Dupard Steven J , Zacharaki Dimitra , Raina Deepak Bushan , Bourgine Paul E
Published: May 2024

Tissue engineering strategies predominantly rely on the production of living substitutes, whereby implanted cells actively participate in the regenerative process. Beyond cost and delayed graft availability, the patient-specific performance of engineered tissues poses serious concerns on their clinical translation ability. A more exciting paradigm consists in exploiting cell-laid, engineered extracellular matrices (eECM), which can be used as off-the-shelf materials. Here, the regenerative capacity solely relies on the preservation of the eECM structure and embedded signals to instruct an endogenous repair. We recently described the possibility to exploit custom human stem cell lines for eECM manufacturing. In addition to the conferred standardization, the availability of such cell lines opened avenues for the design of tailored eECMs by applying dedicated genetic tools. In this study, we demonstrated the exploitation of CRISPR/Cas9 as a high precision system for editing the composition and function of eECMs. Human mesenchymal stromal/stem cell (hMSC) lines were modified to knockout VEGF and RUNX2 and assessed for their capacity to generate osteoinductive cartilage matrices. We report the successful editing of hMSCs, subsequently leading to targeted VEGF and RUNX2-knockout cartilage eECMs. Despite the absence of VEGF, eECMs retained full capacity to instruct ectopic endochondral ossification. Conversely, RUNX2-edited eECMs exhibited impaired hypertrophy, reduced ectopic ossification and superior cartilage repair in a rat osteochondral defect. In summary, our approach can be harnessed to identify the necessary eECM factors driving endogenous repair. Our work paves the road towards the compositional eECMs editing and their exploitation in broad regenerative contexts.
LncRNA Snhg3 aggravates hepatic steatosis via PPARγ signaling
Authors: Xie Xianghong , Gao Mingyue , Zhao Wei , Li Chunmei , Zhang Weihong , Yang Jiahui , Zhang Yinliang , Chen Enhui , Guo Yanfang , Guo Zeyu , Zhang Minglong , Ngowi Ebenezeri Erasto , Wang Heping , Wang Xiaoman , Zhu Yinghan , Wang Yiting , Li Xiaolu , Yao Hong , Yan Li , Fang Fude , Li Meixia , Qiao Aijun , Liu Xiaojun
Published: May 2024

LncRNAs are involved in modulating the individual risk and the severity of progression in metabolic dysfunction-associated fatty liver disease (MASLD), but their precise roles remain largely unknown. This study aimed to investigate the role of lncRNA Snhg3 in the development and progression of MASLD, along with the underlying mechanisms. The result showed that Snhg3 was significantly downregulated in the liver of high-fat diet-induced obesity (DIO) mice. Notably, palmitic acid promoted the expression of Snhg3 and overexpression of Snhg3 increased lipid accumulation in primary hepatocytes. Furthermore, hepatocyte-specific Snhg3 deficiency decreased body and liver weight, alleviated hepatic steatosis and promoted hepatic fatty acid metabolism in DIO mice, whereas overexpression induced the opposite effect. Mechanistically, Snhg3 promoted the expression, stability and nuclear localization of SND1 protein via interacting with SND1, thereby inducing K63-linked ubiquitination modification of SND1. Moreover, Snhg3 decreased the H3K27me3 level and induced SND1-mediated chromatin loose remodeling, thus reducing H3K27me3 enrichment at the Pparg promoter and enhancing PPARγ expression. The administration of PPARγ antagonist T0070907 improved Snhg3-aggravated hepatic steatosis. Our study revealed a new signaling pathway, Snhg3/SND1/H3K27me3/PPARγ, responsible for mice MASLD and indicates that lncRNA-mediated epigenetic modification has a crucial role in the pathology of MASLD.
An automated information extraction system from the knowledge graph based annual financial reports
Authors: Mohsin Syed Farhan , Jami Syed Imran , Wasi Shaukat , Siddiqui Muhammad Shoaib
Published: May 2024

This article presents a semantic web-based solution for extracting the relevant information automatically from the annual financial reports of the banks/financial institutions and presenting this information in a queryable form through a knowledge graph. The information in these reports is significantly desired by various stakeholders for making key investment decisions. However, this information is available in an unstructured format making it much more complex and challenging to understand and query manually or even through digital systems. Another challenge that makes the understanding of information more complex is the variation of terminologies among financial reports of different banks or financial institutions. The solution presented in this article signifies an ontological approach to solving the standardization problems of the terminologies in this domain. It further addresses the issue of semantic differences to extract relevant data sharing common semantics. Such semantics are then incorporated by implementing their representation as a Knowledge Graph to make the information understandable and queryable. Our results highlight the usage of Knowledge Graph in search engines, recommender systems and question-answering (Q-A) systems. This financial knowledge graph can also be used to serve the task of financial storytelling. The proposed solution is implemented and tested on the datasets of various banks and the results are presented through answers to competency questions evaluated on precision and recall measures.
Alzheimer’s diseases in America, Europe, and Asian regions: a global genetic variation
Authors: Hossain Rahni , Noonong Kunwadee , Nuinoon Manit , Lao-On Udom , Norris Christopher M. , Sompol Pradoldej , Rahman Md. Atiar , Majima Hideyuki J. , Tangpong Jitbanjong
Published: May 2024

Background

Alzheimer’s disease (AD) is one of the multifaceted neurodegenerative diseases influenced by many genetic and epigenetic factors. Genetic factors are merely not responsible for developing AD in the whole population. The studies of genetic variants can provide significant insights into the molecular basis of Alzheimer’s disease. Our research aimed to show how genetic variants interact with environmental influences in different parts of the world.

Methodology

We searched PubMed and Google Scholar for articles exploring the relationship between genetic variations and global regions such as America, Europe, and Asia. We aimed to identify common genetic variations susceptible to AD and have no significant heterogeneity. To achieve this, we analyzed 35 single-nucleotide polymorphisms (SNPs) from 17 genes (ABCA7, APOE, BIN1, CD2AP, CD33, CLU, CR1, EPHA1, TOMM40, MS4A6A, ARID5B, SORL1, APOC1, MTHFD1L, BDNF, TFAM, and PICALM) from different regions based on previous genomic studies of AD. It has been reported that rs3865444, CD33, is the most common polymorphism in the American and European populations. From TOMM40 and APOE rs2075650, rs429358, and rs6656401, CR1 is the common investigational polymorphism in the Asian population.

Conclusion

The results of all the research conducted on AD have consistently shown a correlation between genetic variations and the incidence of AD in the populations of each region. This review is expected to be of immense value in future genetic research and precision medicine on AD, as it provides a comprehensive understanding of the genetic factors contributing to the development of this debilitating disease.
Patrones de uso de suelo agrícola y residencial y sus efectos sobre la mantención de la biodiversidad ribereña en el sur de Chile
Authors:   , Goni del Río Rafael E.
Published: May 2024

El desarrollo de actividades económicas como la agricultura, ganadería o plantaciones forestales han generado deforestación y degradación de bosques, dejando escasos remanentes de bosques disponibles para la conservación de la biodiversidad en paisajes productivos. Más aún, el creciente aumento de la demanda de tierras agrícolas para el uso residencial o parcelas de agrado pueden generar nuevas presiones en los bosques remanentes, como reemplazo de especies nativas por especies exóticas y la simplificación de bosques con fines estéticos. Nuestro objetivo fue evaluar los efectos de la cobertura-uso de suelo en la mantención de bosques ribereños en un paisaje agrícola con un fuerte boom de uso residencial en la cuenca del río Toltén. Mediante fotointerpretación de imágenes disponibles en Google Earth Pro® evaluamos el aumento en viviendas para uso residencial (no agrícola) en buffers de 643,4-m de radio (130,04 ha) en 59 puntos elegidos al azar en la cuenca del río Toltén en los años 2012 y 2022. Nuestro análisis muestra un aumento de 14 (SD = 17) casas en promedio en la cuenca del río Toltén (73,36% incremento promedio). La cobertura-uso de suelo no cambió en gran medida, con un 81,94% de Permanencia y un 18,06% de Cambio para todas las clases. La cobertura de Bosque mantuvo un 26% y el suelo de uso agrícola un 48,79%. El Cambio Neto de Bosque por Incremento de Viviendas observado en la cuenca es positivo, con algunas diferencias dependiendo de la localidad en cuestión (Cordillera, Valle y Costa). Cuando relacionamos el Incremento de Vivienda con cambios en el Bosque, encontramos que el bosque podría incrementar en algunas localidades conforme aumentan las viviendas. Nuestros resultados sugieren que existe un proceso de transformación del uso del suelo agrícola hacia un uso de tipo residencial, principalmente en las zonas que tienen alto valor turístico. Luego, el incremento de viviendas bajo un boom de segunda vivienda y el respectivo aumento de población podría implicar un efecto positivo, al menos en la cobertura de bosque o árboles nativos.
Harnessing Cold Plasma: An Innovative Strategy for Managing Postharvest Fungal Infections in Plants
Authors: Shanmugaraj C. , Jaiganesh V. , Kumar H.M. Akshay , Biswas M.K.
Published: May 2024

Researchers in plant pathology in recent times; have faced obstacles in finding chemical-free methods to combat postharvest fungal infections on a large scale. While conventional approaches like heat treatments have been utilized, they often present drawbacks such as altering food quality or causing harm to the environment. An encouraging alternative is a cold plasma, which consists of a blend of gas-derived atoms, excited molecules, and charged particles. Unlike alternative treatments, cold plasma has demonstrated no adverse effects on fresh produce or the environment. This review delves into the potential of cold plasma technology in managing postharvest fungal diseases, offering insights into plasma generation systems and examining both in vivo and in vitro studies. By evaluating the benefits, constraints, and current research gaps, this review seeks to guide for implementation of cold plasma technology in commercial settings.
The Addition of Avocado Seed Flour in Reduced Fat Mayonnaise as Stabilizer
Authors: Juliana Cantika Putri , Evanuarini Herly , Amertaningtyas Dedes
Published: May 2024

Aims: This study aims to determine the quality of mayonnaise by adding avocado seed flour as a stabilizer based on pH, viscosity, stability emulsion, emulsion droplets, acidity, and color analysis (L a* b*).
Study Design: This study are an laboratory experimental with a completely randomizeddesign.
Place and Duration of Study: This study are located in Laboratory of Animal Product Technology, Faculty of Animal Science, Universitas of Brawijaya.
Methodology: This research method used was laboratory experimental with a completely randomized design with 4 treatments and 4 replications.
Results: Avocado seed flour is added to the mayonnaise formulation at 0%, 1%, 2% and 3% sensory evaluation of the total ingredients used. The variables measured are pH, viscosity, stability emulsion, emulsion droplets , acidity, color analysis (L a* b*). The results showed that the treatment had a very significant effect (P<0.01) on pH, viscosity, stability emulsion, emulsion droplets, acidity and color analysis (L a* b*). It can be concluded that the best treatment in this study was mayonnaise woth the addition of 1% avocado seed flour.
Conclusion: This study concluded that the addition of avocado seed flour at 3% can produce mayonnaise with the characteristics of pH, viscosity, emulsion stability, acidity, emulsion droplets, and color analysis.
The Effect of the Fed Interest Rate Hikes on the Financial Crisis Evidence from Emerging Market Economices
Authors: Li Xinru
Published: May 2024

The purpose of this paper is to systematically study the economic consequences of this policy adjustment by analysing in depth the five interest rate hike actions of the Federal Reserve and their chain reactions in emerging market economies, applying economic principles and methods. In particular, the central question of concern is whether the Fed's interest rate hiking policy constitutes an important trigger of the financial crisis in emerging markets. In order to shed light on this complex phenomenon in a comprehensive manner, this paper not only analyses in depth the macroeconomic logic behind the Fed's interest rate hike, but also explores its transmission mechanism in emerging market economies, as well as the economic vulnerability of these countries in the face of external shocks. The results of the study show that the collapse of emerging countries as a result of the Fed's interest rate hikes seems to be inevitable, but we can draw insights from it: actively promoting the reform of the international monetary system and supporting the inclusion of more types of currencies in the international trade and investment settlement system has become a common choice, including for some Western countries, as well as the need to continue to optimise the economic structure of the domestic economy and to strengthen the ability to manage and control the comprehensive risks.
Relationship between Teacher Professional Development and use for ICT in Teaching and Learning in Primary Schools in Sabuli Sub-County, Wajir County
Authors: Mohamed Mohamed Issak , Ali Aden , Rotich Stephen
Published: May 2024

Information and communication technology use in education has become an indispensable aspect in the contemporary education system. This explains why many governments including Kenya government have invested in information and communication technology to foster the quality of education. However, despite efforts to avail information and communication technology resources, their use and impact on instructional delivery has been minimal, especially in primary schools in Kenya. Consequently, there has been concern on relationship between availability of information and communication technology and teacher professional development in primary schools. This situation has necessitated the proposed study which is aimed at assessing the relationship between teacher professional development and use for ICT in teaching and learning in primary schools in Sabuli sub-county, Wajir County, Kenya.  The study used correlation research design. The target population 94 teacher comprising 30 head teachers and 64 teachers of primary schools in Sabuli sub-county, Wajir County. Given the small number of teachers in public primary schools in Sabuli sub county, the study purposively selected all teachers and head teachers as participant to avoid reducing the ambiguity of a study. Thus, the sample population was 94 respondents. The researcher gathered data using questionnaires from teachers and used semi-structured interview for head-teachers. Data was analysed using descriptive and regression statistics. The findings highlight a statistically significant positive relationship between teacher professional development and ICT use, indicating a direct relationship between the two variables.
Apparent and True Digestibility in Clarias gariepinus, Burchell, 1822 FED Soyabean Meal Based Diets Supplemented with Protease
Authors: Oyedokun Jacob Oyeleye , Ogunwole Olugbenga Adeniran , Adene Ibidun Comfort , Oladele Ademuyiwa Hafiz , Sunday Yewande , Obosi Kenneth , Fawole Olaolu Olalekan
Published: May 2024

Soyabean meal (SBM) could be a suitable replacement for the expensive fishmeal but for its low digestibility in fish. However, protease supplementation could improve digestibility of SBM based diets. Therefore, apparent and true digestibility in Clarias gariepinus fed SBM based diets supplemented with protease were investigated. Six diets containing varied inclusion levels of protease (ppm) in solvent extracted soybean-based diets (SESBD) were formulated; Control (without protease), SS100 (100), SS200 (200), SS300 (300), SS400 (400), SS500 (500). The Clarias gariepinus (n=720) weighing 12.00±0.10g were fed to satiation with the diets for 12 weeks. Each treatment was in triplicate. Protease supplementation significantly (P<0.05) influenced the weight gain of C. gariepinus with the higher value in fish fed SS400 (44.63±3.13) and least value in control diet (32.03±0.65).  FCR had a significantly (P<0.05) least value in C. gariepinus fed SS400 (1.62±0.18) but similar (P>0.05) to C. gariepinus diet SS300 (1.88±0.11). Supplemental protease in soyabean-based diet improved (P<0.05) apparent protein digestibility of C. gariepinus on diet SS400 (87.38±1.10) but similar (P>0.05) to C. gariepinus on diet SS200 (87.29±0.97). Also, true lysine digestibility was enhanced with protease supplementation in soybean-based diet with the higher value in diet SS200 (95.90±0.07). Optimal FCR occurred SESBD of 350ppm dietary inclusion (R2= 0.8147) of protease.  The findings suggest that, protease supplementation in solvent extracted soyabean based diet could improve growth performance and amino acid digestibility in C. gariepinus at 350ppm inclusion level.
Study of the Relation between Aging and Pesticides: A Review
Authors: Cristina-Pereira Renata , Ribeiro Anna Luiza de Araújo , Nunes Anna Cláudia Ferreira , Guereschi Luca Casale , Araújo Maria Amália Garcia da Silveira , Gonçalves-Mendes Maria Tereza , Trevisan Kaynara , Silva Heberson Teixeira da , Aversi-Ferreira Tales Alexandre
Published: May 2024

Aims: The main aim of this study was to use specific data from the literature on ageing, correlating this with the pesticide contamination, in order to understand the relationship with an increasingly ageing population.
Study Design: A systematic review was performed.
Place and Duration of Study: Laboratory of Biomathematics of the Federal University of Alfenas, Minas Gerais State, Brazil, between April 2023 and August 2023.
Methodology: A systematic search of articles was performed using the CAPES Periodic platform, a searcher from the Education Ministry of Brazil that contains Web of Science, Scopus, MedLine, from August 2020 to May 2023. For this review, the subject’s “aging theory”; “neuroscience and pathologies to aging”; “aging and aging-associated changes”; “pesticides and pesticide toxicity”; “pesticide toxicity and neurotoxicity”; “longevity and healthy aging”; “aging human and pesticides” were searched together using the type of material “articles” in English language. Some articles about “population growth”; “world population”; “population-aging” were used for epistemological composition of this work content subjects.
Results: From the 19.720 articles after the exclusion and the inclusion criteria made with the subjects most pertinent to the objectives of this work; 19.570 articles were excluded, remaining 150 ones, of which 116 were qualitative in scope and 34 quantitative.
Conclusion: The complex relationship between the pesticide contamination and the condition of the exposed individual may be associated with premature ageing and a greater susceptibility to debilitating age-related diseases. Although technology is increasingly improved in its innovations, health and environmental regulations have not been able to rid the production processes of their potential to pollute the environment and cause health problems for those exposed to them.
Effect of FYM and Different Levels of Panchgavya on Growth and Establishment of Papaya (Carica papaya L.) cv. Red Lady
Authors: Kumar Saurav , Topno Samir E. , Bahadur Vijay
Published: May 2024

Today, with the advancement of environment pollution and health that is obtained from the improper use of inorganic fertilizer, production and use of organic fertilizer is considered as an important approach in the field of soil science in the world’s interest to investors. Research was conducted during the period 2023 on central research farm of department of horticulture, (NAI) SHUATS, Prayagraj. Field trial was designed on Randomized Block Design with three replications and ten treatments. Seedling were raised in polybag and 45 days old seedling were transplanted to the main field. Manure and fertilizer were applied as per treatment in ten equal split doses at 30,60 and 90days intervals. The treatment T9 (RDF) FYM+ Panchgavya (90ml/l) registered significantly maximum vegetative growth, chlorophyll content and survivality %. On the basis of our experimental findings, it can be concluded that the best result was found in treatment T9 (RDF) FYM+ Panchgavya (90ml/l) in term of vegetative growth parameters viz., plant height (cm), Number of leaves per plant, stem diameter (mm), leaf area (cm2) and root to shoot ratio, leaf area index (LAI), chlorophyll content and survivality % of papaya (Carica papaya L.) cv. Red lady.
The Effect of Mannitol and Nano Urea on Terminal Heat Stress on Wheat (Triticum aestivum L.)
Authors: Zaidi Syed Tazeen , Singh Ashok Kumar , Pandey Anand Kumar , Singh Ankit , Rai Aniket Chandra , Kumar Kamal , Kumar Ravindra , Singh Alok Kumar
Published: May 2024

The present investigation was conducted during Rabi season, 2022-23 & 2023-24 at the student instructional farm (SIF) of Acharya Narendra Deva University of Agriculture and Technology, Kumarganj, Ayodhya- 224229 (U.P.). The experiment was conducted in randomized block design with three replications, seven treatments and wheat variety (HD 2967). The treatment was comprised of control distilled water spray, Mannitol 25, 50, 100 ppm and Nano urea 25, 50, 100 ppm respectively, which was foliar sprayed at 30 DAS. The observations have been studied on growth, bio-chemical, yield and yield attributes of wheat. Observations were recorded at 60, 90 DAS and at maturity stages for timely sowing (15 November) and late sowing (15 December). However, yield and yield parameters were taken at the time of harvesting of the crop. Foliar spray of mannitol and nano urea were performed well at 60, 90 DAS and at maturity parameters. Foliar application of nano urea with 25 ppm was recorded superior on plant height (cm), dry weight plant-1 (g), chlorophyll content in leaves (SPAD value), Catalase activity (g-1 fresh weight min-1), Peroxidase activity (mg g-1 fresh weight min-1), Super oxide dismutase activity (mg g-1 fresh weight min-1) However, yield and yield attributes viz length of spike, number of tillers plant-1, number of grains spike-1, grain yield plant-1 It is concluded from the result that foliar spray of nano urea 25 ppm was found most effective to increasing all characters and yield parameters of wheat.
Anti-oxidant and Wound Healing Potentials of Gnetum africanum Welw and Ficus vogelii Miq Extracts
Authors: Coker Morenike E. , Adewuyi Olufunmilayo A. , Emikpe Benjamin O.
Published: May 2024

Background: Gnetum africanum and Ficus vogelii are vegetables consumed in some parts of Africa. They are used in ethno medicine for treatment of different diseases, and are particularly known to hasten wound healing. The study aimed at investigating the wound healing properties of the plants in a rat model.
Materials and Methods: The powdered leaves of the two plants were successively extracted with hexane, ethyl acetate and methanol using a Soxhlet apparatus. The crude methanol extract was screened for secondary metabolites and anti-oxidant properties. The wound healing activity was evaluated using excision wound model. Thirty healthy female Wistar albino rats (150-200 kg) were used for the experiment and randomized into 5% extract + ointment, 3.5% extract + ointment, simple ointment, and gentamicin treatment groups. The ointments were administered topically daily, and wound contraction was measured every alternate day. The percentage wound closure rate and histopathology of healed wound area were determined. The antioxidant activity of the plants was determined using the DPPH scavenging activity and ferric ion reducing antioxidant power assay (FRAP).
Results: The methanol extracts of both plants showed the presence tannins, alkaloids, flavonoids, saponins, and steroids in varying amounts. The antioxidant assays revealed that the extracts of both plants had good anti-oxidant properties. Extracts of Gnetum africanum at 3.5% w/w and Ficus vogelii 5% w/w exhibited potent healing activity, eliciting 100% wound closure by day 7.
Conclusion: The study revealed that Gnetum africanum and Ficus vogelii have wound healing properties which scientifically justifies its use for treatment of wounds traditionally and could be developed into useful drugs for wound treatment and management.
Screening of Onion (Allium cepa L.) Genotypes for High Yield Potential in Mid Hills Region of Himachal Pradesh
Authors: Yogita . , Srishti .
Published: May 2024

Onion (Allium cepa L.) is one of the most important bulbous vegetable crops, belongs to the family Amaryllidaceae. Thirty genotypes were taken under study. Sufficient significant variation was observed among all the genotypes for all the characters under study. The maximum plant height was seen in the genotype UHF-ONI-13 (69.08 cm) while, minimum in the genotype UHF-ONI-7 (34.15 cm). Highest polar diameter and equatorial were represented by the genotype UHF-ONI-13 (5.59 cm) and Bhima Kiran (5.99 cm), respectively. There were nine genotypes which exhibited globular shape, three showed torpedo shape and eighteen showed flat shape. The majority, comprising 18 genotypes, exhibited a dark red color for their bulb skinThe genotype recorded to have earliest 50 per cent neck fall was UHF-ONI-4 (129.67 days). Maximum bulb weight was recorded by the genotype UHF-ONI-13 (82.95 g). Bulb yield per plot and per hectare was observed maximum in UHF-ONI-13 (8.19 kg and 436.86 q). UHF-ONI-13, UHF-ONI-15 and UHF-ONI-16 performed better than other genotypes for yield and other imperative horticultural characters. Thus, these genotypes can be used for further breeding improvement programmes of onion for different traits.