bluuebunny/crossref_metadata_2025 huggingface dataset:
QUEBRADEIRA DE COCO E DOUTORA? SIM, SENHORA! O DEVIR DE UMA PROFESSORA PARA O ENSINO DE MATEMÁTICA
Authors: Oliveira Kelly Almeida de , Cruz Maria do Carmo Alves da , Moura Sebastião Rodrigues , Vizolli Idemar
Published: May 2024

Nesta investigação, foram tecidas compreensões sobre a história de vida de uma Quebradeira de coco em formação doutoral para o ensino de Matemática. As memórias da Profa. Maria, autora e colaboradora da pesquisa, foram narradas no memorial reflexivo para ingresso em um programa doutoral, em uma carta redigida por ela aos seus professores de Educação Básica, e em uma entrevista realizada por aplicativo de mensagens – corpus da pesquisa. O material empírico, composto por estes textos, foi interpertado, tendo como referência teórica as contribuições de Bergson, Merleau-Ponty e Spinoza, sob o viés da Análise Textual Discursiva na perspectiva de Moraes e Galiazzi e o Círculo Hermenêutico de Ricoeur, nas quais foram identificadas três fluxos para interpretação. Os resultados revelam os desejos de viver, os modos de compartilhar suas experiências e as possibilidades de esperançar de pessoas Quebradeiras de coco que fazem outras escolhas profissionais.
L1 content adaptations and English language teaching at tertiary level: Case of EFL learners at Tlemcen University
Authors: Hadjadj Choayb
Published: May 2024

The Algerian reforms in higher education have shifted from the communicative approach towards the Competency-Based Instruction and the role of the teacher has changed to someone who caters to his learner's needs. On the other hand, the Englishization process of Algerian higher education obliged subject matter teachers in different fields to learn English, which is considered a foreign language in Algeria. This exploratory research paper strives to present the findings of a study measuring the success of English Medium lectures relying on L1 content adaptations. In other words, this study examines the adapted English lectures’ content taught to students belonging to the Department of Political Sciences studying at Tlemcen University, to investigate which changes, if any, accompany the linguistic shift from L1 to English-medium teaching. It takes into account our target population, which is represented by 50 Master One Public Administration students who belong to the University of Tlemcen. Two research instruments were used in this study: an achievement test and a questionnaire.  The analysis revealed the learner's good quality output and positive response to the Learning Oriented Assessment (LOA) model.
Keywords: Content adaptations; Englishization; integrated content and language; learning-oriented assessment ; political sciences.
Background of The Board of Director and Financial Intermediary: Does It Contribute to The Performance of Islamic Banks?
Authors: Rahmawati Alvi
Published: May 2024

This study aims to examine the effect of women leadership, education level, financing and investment on the profitability of Islamic banks. The type of data used is secondary data in the form of annual reports of Islamic banks for the 2016-2020 period. Data collection was carried out using purposive sampling technique so that the sample obtained for research was 12 Islamic banks. The analytical tool used in this panel data regression with dummy variables is e-views 10 software. The results showed that partially financing and investment have a positive and significant effect on the profitability of Islamic banks, while women leadership and education level have no effect on profitability. Simultaneously, women's leadership, education level, financing and investment have an influence on profitability. Then based on the results of the determination test shows that the independent variables in the form of women's leadership, education level, financing and investment are able to explain the dependent variable profitability by 99%, while the other 1% is explained by other variables not mentioned in this study.
The Impact of Cement Industry Activity on The Environmental Quality of Settlements in Tipar Kidul Village, Ajibarang, Banyumas
Authors: Khansabyla Farah , Giyarsih Sri Rum
Published: May 2024

The quality of settlement environments surrounding industries is crucial as it reflects the living conditions affected by industrial activities. A study conducted in Tipar Kidul Village aimed to determine the impact of cement industry activities on the settlement environment. The method of this research uses survey within a multistage random sampling survey. The data collection uses interview. The data analysis is simple linear regression with the accuracy testing including validity, reliability, normality, and linearity tests. The research showed that a majority (62%) of the settlement environments conducted in medium-quality conditions. The researched showed industries play a significant role in taking negative impacts on settlements. Industries tend to make settlements uncomfortable to live in due to various activities. Moreover, a significant correlation was observed, indicating a significant influence with a very strong strength that 76.1% between the quality of settlement environments in Tipar Kidul Village and the activities of the cement industry. The cement industry activities impacted to settlement by affecting air pollution, noise from trucks, and machines. Corporate social responsibility program in Tipar Kidul Village included two program, funding program that gave 50.000 rupiah/person and in 2017 cement industry company helped Tipar Kidul Village to reconstruct along Tipar Kidul Village.
Soft skills development in the process of teaching “Tourism” students a foreign language
Authors: Bortnikova T. G. , Dolzhenkova M. I.
Published: May 2024

Importance. Soft skills formation as a part of teaching a foreign language to students of the educational direction “Tourism” contributes to communication skills, empathy, creativity and flexibility of thinking, which are necessary in their future professional activities. The purpose of this study is: 1) analysis of the goals of teaching a foreign language and their correlation with the process of developing hard and soft skills; 2) conducting an empirical study to test the possibility of developing soft skills when teaching a foreign language; 3) identification of significant issues related to the interpretation and use of various cultural codes in communication activities. Attention is focused on the fact that behavioral stereotypes can be variably interpreted depending on which linguistic and cultural communities the communicants belong to. It is emphasized that familiarity with the cultural codes of the studied language and trainings on the development of soft skills can significantly improve the decoding and communicative abilities of students in the process of working with the material for creating advertising texts of tourist destinations and excursion programmes.

Materials and Methods. The experiment is carried out at Derzhavin Tambov State University with the aim of compiling on its basis fragments of research based on the relevance of the topic, a review of scientific literature (definitions and experimental data published in this field of knowledge), selection of bibliography and results’ analysis of its experimental verification. The experiment is based on the use of foreign languages teaching methods. The criteria for selecting educational material are texts related to the popularization and advertising of tourist destinations and step-by-step training is aimed at developing soft skills within the framework of game-based educational activities.

Results and Discussion. Step-by-step training has shown its success in solving a number of assigned tasks. Students become more flexible in the communication process, showing the correct reactions in accordance with the situation and the target audience, the skills of formulating and implementing communication goals are developed (in such aspects as informational, informative, normative), choosing and using established constructs within the framework of the relevant situation, analysis and synthesis of the results of the dialogue.

Conclusion. Based on the results of the experiment, the conclusion is made about the significant didactic potential for soft skills formation within teaching a foreign language. The cognitive and affective aspects of student training have been identified, contributing to the soft skills development. Specific stages of work are proposed, combining various forms of presenting information, professional competence and maintaining successful dialogue with different linguistic and cultural groups in a foreign language.
Typology of speech errors by native speakers (on the example of the French language)
Authors: Zykova A. V. , Nezhina L. A.
Published: May 2024

Importance. The characteristics of the concepts “linguistic errors” and “linguistic norm” (subjective and objective) in the process of teaching native and foreign languages are given, which determines the significance of work in the modern multicultural space. The definitions of “speech culture” and “usus” are considered, and a typology of speech errors is described, which is divided according to aspects of the language: phonetics, grammar and vocabulary (stylistics).

Research Methods. Examples of speech errors by French speakers are presented and analyzed based on the analysis of statistical data conducted by the French publications Le Figaro, Le Conseil Rédaction, Toploc, which clearly demonstrate how the language norm manifests itself and works.

Results and Discussion. The conditions for describing the comparative and comparative analysis of contacting languages are substantiated as an important condition for identifying language difficulties and errors in language structures for the further application of this knowledge in the methodology of teaching both the native language and French and other foreign languages.

Conclusion. The knowledge gained will allow students to improve their sociolinguistic competencies in the future, and the results of the study can be used in revising existing programs for the French language and organizing training in a more detailed consideration of the methodological support for teaching French: creating teaching aids, developing video materials and control.
An Algorithm for Waiting Times between Imaging Studies with Contrast Media and Prevention of Interference in Clinical Laboratory Tests
Authors: Freitas Francisco
Published: May 2024

N/a.
Employment Instability, Family Formation, and Motherhood Penalties : Comparative and Life Course Perspectives
Authors:   , Hsu Chen-Hao
Published: May 2024

Women’s work and family life courses have experienced remarkable changes since the 1970s. Almost all developed countries across Europe, Northern America, and East Asia have to some extent experienced a delaying and declining trend of marriage and fertility. Meanwhile, with women’s increasing education and labour force participation, a gender revolution against the conventional male-breadwinning family model has placed women’s gainful employment at the center of household economics. Over the past few decades, population and family researchers across disciplines have been dedicated to exploring whether and how these two macro-level trends are coevolving, reinforcing, or inhibiting each other. In the centrality of this issue is to understand the micro-level relationship between women’s work and family behaviours. Specifically, it is crucial to examine how women’s working careers are affecting and being affected by family formation, including marriage or cohabiting union formation and childbirth. In this dissertation, I consider women’s family formation as a stepwise process consisting of three parts: (1) forming a partnership union (marriage or cohabitation), (2) the transition to motherhood, and (3) the post-motherhood life course. With a particular focus on the work-related causes and consequences of family formation, this dissertation covers the following three general questions. First, how women’s employment situations affect their transition to partnership union, including cohabitation and marriage? Second, how women’s employment situations affect their birth transitions? Third, how motherhood transitions affect women’s post-motherhood career outcomes? Building on these three general questions, I further investigate advanced topics regarding the institutional embeddedness of work-family relationship and their life course dynamics. The overarching goal of this dissertation is to systematically study the relationship between women’s work and family formation. Taking a holistic perspective, I study the employment-related causes and consequences of women’s family formation process including union formation, childbirth transitions, and post-motherhood life courses. Rather than conceptualizing the linkage between women’s work and family behaviours as a static, homogeneous relationship, I added an institutional and a longitudinal dimension to emphasize the contextual embeddedness and time dynamics of individual life courses. For women, work and family situations are both important factors triggering social stratification. Moreover, short-term disadvantages in these two dimensions could reinforce each other under certain conditions, which might result in cumulative disadvantages throughout individual life courses. Therefore, it is crucial for scholars and policymakers alike to better understand what are the contextual factors that could alleviate or intensify social inequalities emerging from the work-family relationship, and how these inequalities are cumulated over the life course.
Relationship between permanent upper anterior teeth and anthropometric facial measures in different populations
Authors: Longhi Maria Tereza de Moraes , Silva Rafaella Ugrin de Oliveira , Almeida Sâmara Cafa Silva , Esteves Alessandra , Rossi-Júnior Wagner Costa , Figueiredo Camila Helena Machado da Costa , Andrade Ana Luiza Dias Leite de
Published: May 2024

Aim: The main purpose of this study was to conduct a narrative review investigating the possible relationship between permanent maxillary anterior teeth and anthropometric facial parameters in different populations. Methods: Searches were performed in the PubMed, BVS (Biblioteca Virtual em Saúde) and SciELO databases to identify relevant scientific articles using the following search terms: “maxillary anterior teeth”, “facial measurements” and “anthropometry”, in such a way that 218 publications were found. After application of inclusion and exclusion criteria, 13 publications remained for full-text reading. Results:  All studies involved male and female samples and it was notorious that male measurements were unanimously higher than those obtained in the opposite sex. The age of the analyzed participants ranged from 17 to 60 years; however, a mean age of 18 to 25 years was the most investigated in literature. In addition, facial measurements including the bizygomatic width, interpupillary distance, intercanthal distance, interalar width and intercommissural width have been proposed to help determine the correct size of anterior teeth. Conclusion: It was concluded that despite the limited number of studies, some factors that influence dental and facial dimensions, such as sex and age, can be identified. However, there is no standardization of the facial or dental parameters used in the studies, a fact that makes it difficult to establish a universal ratio for clinical dental practice.
Can oral health have an impact on academic performance and school absenteeism?
Authors: Karam Sarah Arangurem , Costa Francine dos Santos , Chisini Luiz Alexandre , Darley Rodrigo , Demarco Flávio Fernando , Correa Marcos Britto
Published: May 2024

Aim: The study aimed to evaluate the association between oral health and academic performance and/or school absenteeism. Methods: Electronic searches were performed of the PubMed, Web of Science, SCOPUS and LILACS/BVS databases. We included observational studies that evaluated the association between dental caries, tooth loss, dental pain or oral health status with school absenteeism or academic performance. The studies had to contain a representative sample of the population: schoolchildren, children or adolescents. After the removal of duplicates, the electronic searches produced 3,789 articles. Of these, 25 studies were included in the systematic review and 13 in the meta-analysis. Results: Considering all the studies evaluated in the meta-analysis, seven articles satisfied 100% of the Joanna Briggs Institute Critical Appraisal checklist, and six contained between 90% and 75% positive answers. The pooled effects showed that the chances of school absenteeism were 31% higher in subjects with dental caries (OR 1.31; 95%CI 1.12-1.54). Students with fair/poor dental health had a 50% higher chance of suffering poor academic performance (OR 1.50; 95%CI 1.22-1.84) and 34% higher chance of having problems at school (OR 1.34; 95%CI 1.06-1.70). Students with a history of toothache had a 3.7 higher chance of being absent from school (OR 6.65; 95%CI 1.60-8.32) and 71% higher chance of missing class due to toothache (OR 1.71; 95%CI 1.15-2.56). Subjects with a history of toothache had a 2.5 times higher chance of suffering poor academic performance (OR 2.58; 95% CI 2.04-3.27). Conclusion: Therefore, students with oral problems were more likely to take time off school and present inferior academic performance.
Evaluation of Clinical and Etiological Characteristics of Cases with Pediatric Lymphadenopathy
Authors: Kara Yalçın , Karakaya Nurhayat , Kızıl Mahmut Can , İşeri Nepesov Merve , Kılıç Ömer , Dinleyici Ener Çağrı
Published: May 2024

Lymphadenopathies are among the common causes of frequent hospital admissions in childhood.Lymphadenopathy (LAP) may be most frequently seen during the follow-up of infectious diseases, but some chronic, malignant, and autoimmune diseases may also be encountered in the etiology of lymphadenopathy.In this study we aimed to investigate the clinical, epidemiologic, and etiological characteristics of pediatric patients presenting with lymphadenopathy.A total of 380 pediatric patients with lymphadenopathy who were followed up in the Eskisehir Osmangazi University Pediatric Infectious Diseases Clinic between January 2015 and January 2023 were included in the study.The mean age of the patients was 84 months and 65% of the patients were male.According to etiologic characteristics; 359(94%) cases had infectious and 21(6) cases had non-infectious LAP.Most frequently nonspecific lymphadenitis (68%), Epstein-Barr Virus (12.8%), cytomegalovirus (3.6%), suppurative lymphadenitis (1.9%) and tuberculous lymphadenitis (1.8%) were observed in cases with LAP. Cases with non-infectious LAP had rheumatologic diseases (n:11), hemato-oncologic malignancies (n: 6), and congenital cysts (n:4). When infectious and non-infectious LAP cases were compared, involved lymph nodes were larger (p:0.04) in the non-infectious group.In the non-infectious group,lymph nodes were relatively harder and conglomerated(p:0.03, p:0.04).Computed tomography scan was more frequently performed in the non-infectious group(p:0.01).Although lymphadenopathy in childhood is mostly due to infectious causes, rheumatologic diseases, hemato-oncologic malignancies, and congenital cysts should be kept in mind, especially in prolonged, treatment-refractory cases. Detailed history and physical examination are the first and the most important steps in the differential diagnosis of cases presenting with lymphadenopathy to prevent the application of unnecessary tests and investigations
Перспективи та шляхи розвитку відеовиробництва в посткарантинний період
Authors: Тріщук Руслан Любомирович
Published: May 2024

Досліджено зміни в споживацьких звичках авдиторії відеоконтенту під впливом пандемії COVID-19. Зазначено, що глядачі стали проводити більше часу для перегляду відеоматеріалів, вони виявляють значний інтерес до нейтральної та об’єктивної інформації й уникають контенту з фейками і маніпуляціями. В умовах посткризової реальності різко зростає попит на оригінальний продукт. Глядачі обирають саме той медіапродукт, який вирізняється серед інших за концепцією, сценарієм і підходом. Вони також цінують своєчасну публікацію відео в мережі та легку доступність до нього, тому важливо підтримувати високий стандарт мобільної оптимізації відеоконтенту та презентувати його вчасно для забезпечення зручного перегляду.
Дослідження засвідчило бажання глядачів бути залученими до певної соціальної групи, об’єднаної спільними інтересами чи вподобаннями, що вказує на формування абсолютно нової тенденції, викликаної безпосередньо пандемією COVID-19, яка свого часу деформувала раніше створені соціальні зв’язки. З урахуванням обмежень соціального дистанціювання, цифровий відеосвіт стає форматом комунікації, який допомагає зменшити розрив між бажаним і реальним. На численних відеоплатформах глядачі матимуть можливість взаємодіяти один з одним, формуючи стійкі соціальні зв’язки.
Щоб бути ефективними в посткарантинний період, відеовиробники повинні активно моніторити будь-які посткризові коливання та реакцію споживачів на той чи інший контент. Вони мають інтегрувати контент під нові формати, проявляючи при тому нестaндaртний пiдхiд дo вiдеoвирoбництвa, творчу гнучкість, креатив та індивідуальний стиль.
Точність оцінки індексу передачі мовлення формантно-модуляційним методом
Authors: Продеус Аркадій Миколайович , Дворник Олександр Олександрович , Найда Антон Сергійович
Published: May 2024

Формантно-модуляційний метод оцінювання розбірливості мовлення, на відміну від відомого модуляційного методу, дозволяє оцінювати не тільки індекс передачі мовлення, але й індекс артикуляції. В даній статті представлено результати дослідження точності оцінювання індексу передачі мовлення повним та швидким варіантами формантно-модуляційного методу. Дослідження виконано методом комп’ютерного моделювання для двох випадків, а саме, для випадку переважної дії шумової завади та випадку сумісної дії шуму та реверберації в приміщенні середнього об’єму. Отримано залежності систематичної та випадкової складових похибки оцінювання індексу передачі мовлення від тривалості тестового сигналу та від відношення сигнал–шум. Показано, що хоча швидкий варіант формантно-модуляційного методу в 4–5 разів поступається повному варіанту за точністю вимірювань індексу передачі мовлення, проте за умови вибору достатньо великої тривалості тестового сигналу можна досягнути бажаної точності оцінювання. Зокрема, зміщення та стандартне відхилення оцінки індексу передачі мовлення, отриманої швидким формантно-модуляційним методом, не перевищують 0,03 та 0,014, відповідно, для тривалості тестового сигналу 16 с.
Організація резервних каналів зв’язку для екстрених ситуацій у середовищах з обмеженою інфраструктурою з використанням технології LPWAN
Authors: Ликов Юрій Володимирович , Олейніков Анатолій Миколайович , Ликова Ганна Олександрівна , Савенко Степан Олександрович , Маковецький Сергій Олександрович
Published: May 2024

В роботі розглянута важливість створення резервних каналів зв’язку в надзвичайних ситуаціях, коли доступ до систем стільникового та супутникового зв’язку обмежений. Метою дослідження є обґрунтування використання технології LoRaWAN як основи для побудови надійних резервних засобів зв’язку. Запропоновано структурну схему пристрою, на прикладі якої промодельовано час його автономності. Показано, що в залежності від режиму роботи цей час складає від 150 до 900 діб. Для оцінки зони радіодоступності пристрою промодельовано максимальну дальність передачі з використанням різних моделей поширення радіохвиль. Результати досліджень показали, що розроблена система екстреного зв’язку на основі протоколу LoRaWAN є ефективною та переважає інші технології бездротового зв’язку в певних умовах.
Overview of Georgian Wine Law
Authors: Nutsubidze Maka
Published: May 2024

While Georgia boasts a rich heritage as the birthplace of wine, with a history of production spanning millennia, the legal framework surrounding Georgian vineyards and winemaking is only now beginning to take shape. Governing the industry are a variety of legal instruments, including the dedicated-on vine and wine law of Georgia, alongside broader legislative statutes and specific regulatory directives. In this article, we delve into the national and international guidelines governing the wine sector, drawing from Georgia's legal landscape.
consommateur moyen de vin et la technique du standard.
Authors: Raffray Ronan
Published: May 2024

Devenu dans sa configuration la plus moderne et sous l’impulsion de l’Union européenne un véritable droit de la régulation du marché vitivinicole, le droit de la vigne et du vin se présente comme une architecture complexe de règles tenant compte des intérêts de toutes les parties prenantes, ce qui implique de légiférer et de juger en considérant notamment les attentes et les forces des consommateurs de vin. Cet acteur final du marché du vin est devenu, sous les traits d’un consommateur de vin normalement informé et raisonnablement attentif et avisé, une figure jurisprudentielle passive, mais incontournable du droit de la vigne et du vin, qu’il s’agisse du droit des indications géographiques, du droit des marques ou du droit des pratiques commerciales trompeuses.
Discoveries in Transforming Student Engagement through Full-Day School Learning Motivation Research
Authors: Azizah Siti Hidayatul , Widyastuti Widyastuti
Published: May 2024

This study examines the learning motivation levels among high-grade students at SD Islam Sabilillah Sidoarjo, utilizing a descriptive quantitative research approach with a sample size of 217 out of a total population of 506 students. Data analysis via descriptive statistical tests revealed that 68% of students demonstrated a moderate level of learning motivation, while 19% exhibited a high level and 13% had a low level. These findings highlight the students' ability to sustain learning motivation during academic activities at school and offer insights for enhancing motivation strategies in full-day school settings, with implications for educational institutions and policymakers.
 
Highlight:

Quantitative assessment of learning motivation in full-day school students.
Representative sample selection via proportionate stratified random sampling.
Insights for educational strategies and improved student engagement outcomes.

 
Keyword: Learning Motivation, Full-Day School, Student Engagement, Descriptive Quantitative Research, Educational Strategies
Decadal Land Use and Land Cover Transformation in Shaheed Bhagat Singh Nagar of Punjab Based on Geospatial Technology
Authors: Sohal Jaskaran Singh , Kaushal Arun , Arora Mohit , Loshali Dikesh Chandra
Published: May 2024

Land use and land cover (LU/LC) is observed to be the primary factor of environmental change on a worldwide scale. Timely and accurate information on LU/LC is very important for efficient planning and management activities. The present study mainly focused on land use and land cover change analysis in district Shaheed Bhagat Singh Nagar of Punjab using remote sensing and geospatial technology. Satellite data of IRS P6 LISS-III (2012 and 2022) were analysed for LU/LC mapping using visual interpretation techniques. The study area was divided into seven LU/LC classes i.e.: agriculture, built-up, waterbody, forest/tree clad area, riverine sand, algae bloom and fallow land /barren land/waste land in which agriculture covers maximum while riverine sand covers minimum area. Satellite derived NDVI and NDWI has been used to derive the spatial variability of vegetation and water. In decadal change the alterations encompass positive trends such as increased agricultural area (31.29%), as well as negative trends including decreased algae bloom (59.82%). Overall accuracy for LISS-III 2012 and LISS-III 2022 were 88.3% and 86.66% respectively with kappa coefficient value as 0.86, and 0.83, respectively. Hotspot areas with major changes were seen in Block Nawanshahr with major increase in built-up area, as well as in Block Saroya and Balachaur of study area with major decrease in Forest area.
Chimp Optimization Algorithm Contribution Support To Increases Energy Efficiency In UWASN
Authors: Kannappan A , Kolagani Nagesh
Published: May 2024

Underwater wireless Acoustic sensor network (UWASN) is employed to communicate between anchor nodes and the sink nodes. In this work, a novel Chimp optimization algorithm is deployed for underwater routing protocol communication, aiming to improve energy efficiency, packet delivery ratio, and throughput. In Chimp, the energy Optimization Algorithm solves the problems of propagation delay and improves battery life, network lifetime, and throughput. The proposed algorithm shows a better result in energy efficiency when compared to the existing buffalo algorithm, resulting in a Mean Delay of 79.17% and propagation delay of 74.35% than the existing counterpart. Especially compared to the buffalo algorithm, the Chimp algorithm has higher decision-making capacity and extended node range. The node range is set from 0 to 100, and the node performance is evaluated using MATLAB simulation software tools
High-Dimensional Semi-Parametric Model StatisticalInference for Model-Free and FDR Controlled Risk FeatureSelection
Authors: song xue-ting , lu zi-tong , gao yu-fan , Xiao Jian
Published: May 2024

Developing high-dimensional statistical inference method to identify the individual features associated with the response is very important in analyzing large-scale datasets from economics, finance, medicine, cancer studies, bioinformatics. However, themodern data sets collected often not only own the high-dimension property but alsoexhibit unknown relationships between the response and its explanatory features.Reliable statistical inference depends on an accurate modeling for the observed data.Such an involved modelling task can be done by the state-of-the-art semi-parametricmodel with few model assumptions. In this paper, based on high-dimensionalsemi-parametric model, we utilize the estimators of unknown parameters’ directions andsymmetrized data aggregation approach to develop a novel and model-free featureselection method for achieving fine-mapping of risk features while controlling the falsediscovery rate (FDR) of selection. The proposed method can be applied for the analysisof both continuous and discrete response data sets. The results of simulation studiesdemonstrate the proposed method has robust feature selection performance whilecontrolling FDR very well. The analysis results of a real ocean microbiome dataindicate our method indeed is effective to detect risk features.
Molecular cloning and characterization of a brassinosteriod biosynthesis-related gene PtoCYP90D1 from Populus tomentosa
Authors: Liu Yang , Tian Songqun , Tang Hu , Yao Xinzhuan
Published: May 2024

Brassinosteroids (BRs), one of the major classes of phytohormones are essential for various processes of plant growth, development, and adaptations to biotic and abiotic stresses. In Arabidopsis, AtCYP90D1 acts as a bifunctional cytochrome P450 monooxygenase, catalyzing C-23 hydroxylation in the brassinolide biosynthetic pathway. The present study reports the functional characterizations of PtoCYP90D1, one of the AtCYP90D1 homologous genes from Populus tomentosa. The qRT-PCR analysis showed that PtoCYP90D1 was highly expressed in roots and old leaves. Overexpression of PtoCYP90D1 (PtoCYP90D1-OE) in poplar promoted growth and biomass yield, as well as increased xylem area and cell layers. Transgenic plants exhibited a significant increase in plant height and stem diameter as compared to the wild type. In contrast, the CRISPR/Cas9-generated mutation of PtoCYP90D1 (PtoCYP90D1-KO) resulted in significantly decreased biomass production in transgenic plants. Further studies revealed that cell wall components increased significantly in PtoCYP90D1-OE lines but not in PtoCYP90D1-KO lines, as compared to wild-type plants. Overall, the findings indicate a positive role of PtoCYP90D1 in improving growth rate and elevating biomass production in poplar, which will have positive implications for its versatile industrial or agricultural applications.
Differential Genotoxicity of Polygoni Multiflori in Rat and Human: Insights from Ames Test and S9 Metabolic Activation System
Authors: Bak Su-Min , Back Seng-Min , Kim Da Yeon , Jeung Na-Young , Kim Nan-Young , Han Kang-Hyun , Kim Yong-Bum , Lee Byoung-Seok , Park Jun Hong , Cho Hee Jun , Lee Hee Gu , Ozden Ozkan , Park Seong-Hoon , Jung Soyoung
Published: May 2024

The Ames test is used worldwide to initially screen the mutagenic potential of new chemicals. In the standard Ames test, S. typhimuriumstrains (TA100, TA98, TA1535, and TA1537) and Escherichia coli (WP2uvrA) are treated with substances with/without cytochrome P450s (CYPs)-induced rat S9 fractions for identifying mutagens and pro mutagens. However, many substances show completely different toxicity patterns depending on whether the liver S9 fraction belongs to rats or humans. The natural product Polygoni Multiflori Radix(PMR)can also show bacterial reverse mutation, followed by the rat or human liver S9 fraction. While PMR elicits reverse mutations in the TA1537 strain in rat liver S9 but not in human liver S9, this mechanism has not been verified yet. To explain this, the differences in metabolic enzymes compositions commonly observed between rats and humans have been implicated. This study aimed to explore the key factors that cause differences in the genotoxicity of PMR between rat and human liver S9 metabolic enzymes. The results of next-generation sequencing (NGS) analysis showed that both rat and human metabolic enzymes caused similar mutations in TA1537. However, when the metabolic enzymes in each S9 fraction were analyzed using ion mobility tandem mass spectrometry (IM-MS), rat- and human-specific enzymes were identified among the cytochrome (CYP) family, especially aryl hydrocarbon receptor (AHR)-related CYPs. These findings suggest that CYP1A1 isoforms contribute to the mechanism of PMR in the Ames test. Therefore, an invitro Ames test might be more reliable in predicting genotoxicity for both rodents and humans. This will also help overcome the limitations of laboratory animal-based toxicity evaluations, which provide unreliable results due to interspecies differences between humans and rodents.
Tectonic control on great earthquake periodicity in south-central Chile.
Authors: Melnick Daniel , Aedo Diego , Cisternas Marco , Brill Dominik
Published: May 2024

Multi-millennial records of great megathrust earthquakes have highlighted differences in periodicity and recurrence behavior. Understanding tectonic processes responsible for these differences is relevant for fault mechanics and hazard models. Here, we present a new paleoseismic record inferred from raised beach ridges in the 2010 Maule earthquake (Mw 8.8) segment in south-central Chile that includes 24 interseismic periods over 4.5 kyr suggesting a weakly-periodic recurrence behavior. In turn, great earthquakes in the adjacent 1960 Valdivia earthquake (Mw 9.5) segment occurred with periodic recurrence over the same period. Both segments have similar amounts of trench sediments as well as rheological and geometrical boundary conditions, but Maule has a wider frontal accretionary wedge and several splay faults rooted in the seismogenic zone whereas Valdivia lacks splay faults and trench sediments are mostly subducted and underplated. These differences may have an impact on upper-plate compliance and megathrust friction, affecting earthquake size and recurrence periodicity.
Exploration and practice of "disease—drug" potential association prediction based on "Swanson framework+Bioinformatics"—a case study of Autism Spectrum Disorder
Authors: Lv Yanhua , Yuan Yuyang , Zhong Xiaoyun , Zhao Hongxia , Qu Baoqiang , Lu Xuechun , Yu Qi
Published: May 2024

Objective
Compared to traditional intermediate concepts, specific bioinformatics entities are more informative and higher directional. This study is based on the BITOLA system and combines bioinformatics methods to determine the intermediate concept which is key to improve efficiency of Literature-based Knowledge Discovery, proposes the concept of "Swanson framework + Bioinformatics", and conducts practice of Literature-based Knowledge Discovery to improve the scientificity and efficiency of research and development.
Methods
Firstly, detected the disease related genes (i.e. differentially expressed genes) according to the results of gene functional analysis as intermediate concepts to carry out Literature-based Knowledge Discovery. Taking the disease "Autism Spectrum Disorder(ASD)" as an example, the potential "disease-drug" association was predicted, and the predicted drugs were verified from the perspective of bioinformatics.
Results
Two drugs potentially associated with ASD were found: fish oil and forskolin, which were closely related to ASD in bioinformatics analysis results and literature verification.The two "disease-drug" association results showed better scientificity. The BIOINF-ABC+ model improves the accuracy of calculations by 76% compared to using the BITOLA system alone.In addition, it also shows high accuracy and credibility in literature verification.
Conclusion
The BIOINF-ABC+ model based on the "Swanson framework + Bioinformatics" has good practicality, applicability, and accuracy in conducting "disease-drug" association prediction in the biomedical field, and can be used for mining "disease-drug" relationships.
Increased non-relapse mortality in older people with allogeneic hematopoietic stem cell transplantation using fludarabine and myeloablative dose of busulfan-based regimen
Authors: Shinohara Akihito , Shindo Michiho , Sakaida Emiko , Uchida Naoyuki , Fukushima Kentaro , Nakazawa Hideyuki , Serizawa Kentaro , Kanda Yoshinobu , Kawakita Toshiro , Ikeda Takashi , Ohigashi Hiroyuki , Ito Ayumu , Wakayama Toshio , Matsuoka Ken-ichi , Fukuda Takahiro , Tanaka Junji , Atsuta Yoshiko , Nakasone Hideki
Published: May 2024

Fludarabine and myeloablative doses of busulfan-based regimens (FluBu4) are used in a wide age range as a reduced toxicity conditioning regimen for allogeneic hematopoietic stem cell transplantation (HSCT). However, their tolerability in older people has not been adequately examined. This retrospective study analyzed data from Transplant Registry Unified Management Program in Japan. Patients who were >15 years old (y/o), had hematological malignancies, and received their first HSCT using FluBu4 between 2006 and 2017 were included. They were categorized into the younger group (<60 y/o, N = 1295) and the older group (≥60 y/o, N = 993). The 3-year overall survival (OS) rate after HSCT was significantly worse in the older group than in the younger group (P < 0.01, 39.9% versus 48.5%). The 3-year non-relapse mortality (NRM) was significantly higher in the older group than in the younger group (P < 0.01, 30.9% versus 23.0%), and the 3-year cumulative incidence of relapse was comparable between the groups. According to the multivariate analysis, age ≥ 60 years was significantly associated with poor OS (P < 0.01) and high NRM (P < 0.01). In subgroup analysis of the older group, the use of additional chemotherapeutic drugs to FluBu4 was significantly associated with poor OS (P = 0.01) and high NRM (P < 0.01). Total body irradiation was significantly associated with high NRM (P < 0.01) and 1-year incidence of sinusoidal obstruction syndrome (P < 0.01) but not with OS. Thus, FluBu4 should be used with caution in older people.
Potential application of bulk RNA sequence in MPNs clinic routine
Authors: Li Shenglong , Wu Sanyun , Xu Mingli , Li Xuedong , Zuo Xuelan , Wang Yingying
Published: May 2024

Philadelphia chromosome negative myeloproliferative neoplasms is a chronic hematological malignancy caused by driven mutations and non-driven mutations. It is considered tumor inflammatory disease, which characterized by dysregulated immune system including aberrant cytokine and abnormal immune cell. A comprehensive view of gene mutation and immune state for each classic myeloproliferative neoplasm patient during different disease stages is highly valuable in guiding treatment choice. Single cell RNA sequence, spatial transcriptome, mass cytometer and multiplex immune staining are very performant in exploring integrative gene mutation and/or immune landscape in oncology, However, they are not used in clinic routine because of its high cost and/or its high dependance of expertise. Bulk RNA sequence could be widely used in clinic with advantage of relative low cost. Furthermore, bioinformatic science progress rends possible to identify gene mutation and immune related genes with bulk RNA sequences simultaneously, this work aims to explore the potential value in interpretating gene mutation and immune landscapes of classic myeloproliferative neoplasm with bulk RNA sequence.
Teledermatology: an Evidence Map of Systematic Reviews
Authors: Chow Aloysius , Smith Helen Elizabeth , Car Lorainne Tudor , Kong Jing Wen , Choo Kay Wee , Aw Angeline Ai Ling , Wong Marie Ann Mae En , Apfelbacher Christian
Published: May 2024

Background: Although the number of teledermatology studies is increasing, not all variables have been researched in equal depth, so there remains a lack of robust evidence for some teledermatology initiatives. This review describes the landscape of teledermatology research and identifies knowledge gaps and research needs.
Methods: Our evidence map was conducted according to the Campbell Collaboration checklist for evidence and gap maps. Eight databases were searched: CINAHL, Embase, PubMed, Scopus, Web of Science, Cochrane Library, JBI Database of Systematic Reviews and Implementation Reports, and OpenGray. From 909 records, 14 systematic reviews published between 2004 and 2023 were included. Our analysis focused on the systematic reviews’ characteristics, dermatological conditions studied, rate of overlap and quality assessment of primary studies reviewed, and main findings reported.
Results: Teledermatology was reportedly comparable with clinic dermatology and generally accepted by patients as a mode of care delivery for dermatological conditions. However, there are concerns about privacy, communication, completeness of information transmitted, familiarity with the technology, and technical problems. Healthcare professionals were generally satisfied with teledermatology, but found telemedicine consultations longer than face-to-face consultations, and less confident in asynchronous teledermatology than conventional consultations. Teledermatology was reportedly more cost-effective than clinic dermatology; especially considering the distance travelled by patients, referral volume to teledermatology, and clinic dermatology costs. Although patients and providers are satisfied with teledermatology, face-to-face dermatology has higher diagnostic and management accuracy. Teledermatology was also used for training medical professionals. Regarding the validity and reliability of teledermatology outcome measures, no significant discussions were found.
Conclusions: COVID-19 spotlighted telemedicine in clinical care, and we must ensure telemedicine continually improves with robust research. Further research is necessary for establishing a standardised outcome set, enhancing accuracy, concordance, cost-effectiveness, and safety, comparing teledermatology with non-dermatologist care, examining its effectiveness in non-Western low and middle-income countries, and incorporating patient involvement for improved study design.
Systematic review registration: The review was registered at https://www.researchregistry.com/ (Unique Identifying Number: reviewregistry878).
Predictors of Response to CDK4/6i Retrial After Prior CDK4/6i Failure in ER+ Metastatic Breast Cancer
Authors: Jhaveri komal , Mai Nicholas , Anjos Carlos Henrique dos , Razavi Pedram , Safonov Anton , Patil Sujata , Chen Yuan , Drago Joshua , Modi Shanu , Bromberg Jacqueline , Dang Chau , Liu Dazhi , Norton Larry , Robson Mark , Chandarlapaty Sarat
Published: May 2024

After disease progression on endocrine therapy (ET) plus a CDK4/6 inhibitor, there is no standardized sequence for subsequent treatment lines for estrogen receptor positive (ER+) metastatic breast cancer (MBC). CDK4/6i retrial as a treatment strategy is commonplace in modern clinical practice; however, the available prospective data investigating this strategy have had inconclusive results. To frame this data in a real-world context, we performed a retrospective analysis assessing the efficacy of CDK4/6is in 195 patients who had previous exposure to CDK4/6i in a prior treatment line at our institution. Among patients who had stopped a CDK4/6i due to toxicity, CDK4/6i retrial either immediately after with a different CDK4/6i or in a further treatment line with the same initial CDK4/6i was both safe and effective, with a median time to treatment failure (TTF) of 10.1 months (95%CI, 4.8-16.9). For patients whose disease progressed on a prior CDK4/6i, we demonstrated comparable median TTFs for patients rechallenged with the same CDK4/6i (4.3 months, 95%CI 3.2-5.5) and with a different CDK4/6i (4.7 months, 95%CI 3.7-6.0) when compared to the recent PACE, PALMIRA, and MAINTAIN trials. Exploratory genomic analysis suggested that the presence of mutations known to confer CDK4/6i resistance, such as TP53 mutations, CDK4 amplifications, and RB1 or FAT1 loss of function mutations may be molecular biomarkers predictive of CDK4/6i retrial failure.
Expression Patterns and Prognostic Model Construction of the Major Histocompatibility Complex-Related Gene Granzyme B in Oral Squamous Cell Carcinoma
Authors: Zhang Hongrong , Zhou Xue , Li Jingyi , Zhang Wanyue , Sun Zheyi , Wang Weihong
Published: May 2024

Oral squamous cell carcinoma (OSCC) accounts for 90% of malignant tumors in the oral and maxillofacial region, known for its high metastatic potential and poor prognosis. This study aims to investigate Major Histocompatibility Complex(MHC) related genes' involvement in OSCC, offering new insights for immunotherapy. We identified differentially expressed genes associated with MHC in OSCC, analyzed copy number variations and pathways enrichment, and developed a prognostic model using Cox regression analysis on patient data. Our model proved to be an independent prognostic indicator, effectively predicting patients' prognosis and showcasing its efficacy in estimating 5-year survival rates. Immunoinfiltration analysis highlighted Granzyme B (GZMB) as a key gene significantly correlated with immune cells, showing varied expression across tumor stages. Additionally, we characterized OSCC tissue grading, finding higher GZMB protein expression in well-differentiated compared to moderately differentiated tissues, both exceeding levels in normal tissues. Our findings suggest the developed prognostic model could serve as a reliable biomarker for OSCC prognosis, emphasizing the crucial role of GZMB in tumor progression.