bluuebunny/crossref_metadata_2025 huggingface dataset:
Improvement of Mean Wave Period Based on Dispersion Relation Filter Using Shore-Based Coherent S-Band Radar
Authors: Liu Han , Chen Zezong , Zhao Chen , Wu Sitao
Published: May 2022

Wavenumber–frequency spectra obtained with coherent microwave radar at upwind-grazing angle consist of energy along the ocean wave dispersion relation and additional features that lie above this relation labeled as “high-order harmonic” and below this relation known as “group line.” Due to these nonlinear features, low-frequency components appear in the radar-estimated wave spectrum and the energy and peak frequency of the dominant wave spectrum decrease, which are responsible for the overestimation of radar-measured wave period. According to the component distribution in the wavenumber–frequency spectrum, a mean wave period inversion method based on a dispersion relation filter for coherent S-band radar is proposed. The method filters out the “group line” and preserves the high-order harmonic to compensate for the energy loss caused by the decrease of peak frequency of the dominant wave spectrum. A two-dimensional inverse Fourier transform is applied to the filtered wavenumber–frequency spectrum. Then the radar-measured velocity sequence is selected to obtain the velocity spectrum via a one-dimension Fourier transform. The wave height spectrum is estimated from the one-dimensional velocity spectrum by the direct transform relationship between the one-dimensional velocity spectrum and the wave height spectrum. Later, mean wave periods can be derived by the first moment of the wave height spectrum. A 13-day dataset collected with a shore-based coherent S-band radar deployed at Zhelang, China, is reanalyzed and used to retrieve mean wave periods. Comparisons between the measurements of radar and wave buoy are conducted. The results indicate that the proposed method improves the wave period measurement for coherent S-band radar.

Significance Statement

This work provides a mean wave period inversion method for coherent S-band radar. The mean wave period is always overestimated due to the “group line” in the wavenumber–frequency spectrum and the energy loss caused by the decrease of peak frequency of the dominant wave spectrum. Therefore, dealing with these estimation errors is important.
Predicting Peak Wind Gusts during Specific Weather Types with the Meteorologically Stratified Gust Factor Model
Authors: Lang Victoria A. , Turner Teresa J. , Selbig Brandon R. , Harris Austin R. , Kahl Jonathan D. W.
Published: May 2022

Wind gusts present challenges to operational meteorologists, both to forecast accurately and also to verify. Strong wind gusts can damage structures and create costly risks for diverse industrial sectors. The meteorologically stratified gust factor (MSGF) model incorporates site-specific gust factors (the ratio of peak wind gust to mean wind speed) with wind speed and direction forecast guidance. The MSGF model has previously been shown to be a viable operational tool that exhibits skill (improvement over climatology) in forecasting peak wind gusts. This study assesses the performance characteristics of the MSGF model by evaluating peak gust predictions during several types of gust-producing weather phenomena. Peak wind gusts were prepared and verified for seven specific weather conditions over an 8-yr period at 16 sites across the United States. When coupled with two forms of model output statistics (MOS) wind guidance, the MSGF model generally shows skill in predicting peak wind gusts at forecast projections ranging from 6 to 72 h. The model performed best during high pressure and nocturnal conditions and was also skillful during conditions involving snow. The model did not perform well during the “rain with thunder” weather type. The MSGF model is a viable tool for the operational prediction of peak gusts for most gust-producing weather types.

Significance Statement

Wind gusts are an important and potentially costly environmental hazard. Wind gusts affect many industrial sectors, including transportation, power generation, forestry, construction, and insurance, but predicting gusts remains a challenging component of weather forecasting. Recent studies have demonstrated that the meteorologically stratified gust factor (MSGF) model shows skill in predicting peak gusts. This study shows that the MSGF model is skillful at predicting peak gusts during specific types of gust-producing weather phenomena at forecast projections up to 72 h, providing further confirmation that the MSGF model is a viable tool for the operational prediction of peak gusts.
Paradimorphite, β-As4S3, a vintage new mineral from Solfatara di Pozzuoli and Vesuvius, Napoli, Italy
Authors: Campostrini Italo , Castellano Carlo , Demartin Francesco , Rocchetti Ivano , Russo Massimo , Vignola Pietro
Published: May 2022

The new mineral paradimorphite corresponds to the high temperature polymorph of As4S3, whose existence was supposed by Arcangelo Scacchi in 1850 in the fumaroles at the Solfatara di Pozzuoli, Campi Flegrei, near Napoli, Italy.

Crystals of paradimorphite are orange yellow, transparent or semitransparent, with adamantine lustre. Habit is prismatic and observed forms are {110}, {101}, {111}, {100}, {010} and {001}. Tenacity is brittle, no distinct cleavage is observed and fracture is conchoidal. The mineral does not fluoresce in long- or shortwave ultraviolet light. No twinning is apparent. The streak is saffron yellow. Hardness (Mohs) = 1–2. The observed density is 3.510(3) g/cm3, calculated density is 3.500 g/cm3. The mineral is orthorhombic, space group Pnma, with a = 9.1577(7), b = 8.0332(6), c = 10.2005(8) Å, V = 750.41(10) Å3 and Z = 4. The eight strongest powder X-ray diffraction lines are [dobs Å(I)(hkl)]: 6.299(48)(011), 5.186(100)(111), 4.174(31)(201), 3.133(34)(022), 3.116(58)(212), 2.980(41)(122), 1.846 (27)(413) and 1.808(23)(134). The structure was refined to R = 0.0229 for 979 reflections with I >2σ(I). Crystals of paradimorphite contain As4S3 molecules, of idealised C3v symmetry, with the four arsenic atoms in a triangular pyramidal arrangement, with sulfur atom bridges on the three adjacent apical edges. Molecular dimensions and conformation are identical within standard uncertainties with those of the low-temperature polymorph dimorphite. No substantial differences, neither in the molecular packing nor in the molecular orientation, could be observed; minor differences being related to intermolecular distances only.
Introduction to a How I Treat series on plasma cell dyscrasias
Authors: Avet-Loiseau Hervé
Published: May 2022

The treatment paradigms for multiple myeloma and amyloidosis have been transformed by novel therapies and continue to be modified in the face of new immunologic agents. In this How I Treat series on plasma cell dyscrasias edited by Associate Editor Hervé Avet-Loiseau, experts in the field discuss the rapidly changing treatment landscape for multiple myeloma and light-chain amyloidosis. Using illustrative cases, they review the role of autologous transplant, novel combination therapies, and the impact of new immunotherapy approaches to these complex and heterogeneous diseases.
Vogt-Koyanagi-Harada disease: the step-by-step approach to a better understanding of clinicopathology, immunopathology, diagnosis, and management: a brief review
Authors: Urzua Cristhian A. , Herbort Carl P. , Takeuchi Masaru , Schlaen Ariel , Concha-del-Rio Luz E. , Usui Yoshihiko , Cuitino Loreto , Papasavvas Ioannis
Published: May 2022

Background

Appraisals of Vogt-Koyanagi-Harada disease (VKH) have become progressively more complete, since its first description in 1906. The availability of new investigational methods has improved our knowledge of the immunopathology, clinicopathology, diagnosis, and management of VKH disease. This review aimed to describe some of the steps that led to better characterization of VKH as a clinical entity.

Methods

We searched on PubMed for articles that described the history of VKH disease and analyzed the progress in disease appraisal with new investigational and imaging methods. In particular, we searched for articles that investigated the clinicopathology, diagnosis, and management of VKH.

Findings

The following developments were considered essential for improving the appraisal and understanding of VKH: (1) the history of the disease, (2) immunopathological mechanisms, (3) clinicopathology, (4) the importance of distinguishing initial-onset from chronic disease, (5) relevant imaging modalities, among which indocyanine green angiography is crucial, (6) diagnostic criteria that facilitate early diagnosis, and (7) the need for early, prolonged, aggressive treatment that combines steroidal and non-steroidal immunosuppression.

Conclusion

Based on these findings, the definition of VKH has improved. VKH disease starts in the choroidal stroma and later involves other structures when it is not diagnosed and treated early. Indocyanine green angiography and enhanced depth imaging optical coherence tomography facilitate early diagnosis and precise monitoring of choroidal inflammation. ICGA is clearly the gold standard for appraisals and follow-ups in VKH disease, however EDI-OCT should be especially considered in those areas where ICGA is not fully available. These modalities have contributed substantially to a “cure” for VKH, when treatment is introduced within the therapeutic window of opportunity.
Galbase: a comprehensive repository for integrating chicken multi-omics data
Authors: Fu Weiwei , Wang Rui , Xu Naiyi , Wang Jinxin , Li Ran , Asadollahpour Nanaei Hojjat , Nie Qinghua , Zhao Xin , Han Jianlin , Yang Ning , Jiang Yu
Published: May 2022

Background

Multi-omics data can provide a stereoscopic view to explore potential causal variations and genes, as well as underlying genetic mechanisms of complex traits. However, for many non-mammalian species, including chickens, these resources are poorly integrated and reused, greatly limiting genetic research and breeding processes of the species.

Results

Here, we constructed Galbase, an easily accessible repository that integrates public chicken multi-omics data from 928 re-sequenced genomes, 429 transcriptomes, 379 epigenomes, 15,275 QTL entries, and 7,526 associations. A total of 21.67 million SNPs, 2.71 million InDels, and 488,583 cis-regulatory elements were included. Galbase allows users to retrieve genomic variations in geographical maps, gene expression profiling in heatmaps, and epigenomic signals in peak patterns. It also provides modules for batch annotation of genes, regions, and loci based on multi-layered omics data. Additionally, a series of convenient tools, including the UCSC Genome Browser, WashU Epigenome Browser, BLAT, BLAST, and LiftOver, were also integrated to facilitate search, visualization, and analysis of sequence features.

Conclusion

Galbase grants new opportunities to research communities to undertake in-depth functional genomic studies on chicken. All features of Galbase make it a useful resource to identify genetic variations responsible for chicken complex traits. Galbase is publicly available at http://animal.nwsuaf.edu.cn/ChickenVar.
Chrysanthemum × grandiflora leaf and root transcript profiling in response to salinity stress
Authors: Liu He , Liu Yu , Xu Ning , Sun Ying , Li Qiang , Yue Liran , Zhou Yunwei , He Miao
Published: May 2022

As high soil salinity threatens the growth and development of plants, understanding the mechanism of plants’ salt tolerance is critical. The Chrysanthemum × grandiflora is a newly developed species with a strong salt resistance that possesses multiple genes controlling its quantitative salt resistance. Because of this multigene control, we chose to investigate the plant stress genes overall responses at the transcriptome level. C. grandiflora were treated with a 200 mM NaCl solution for 12 h to study its effect on the roots and leaves via Illumina RNA sequencing. PAL, CYP73A, and 4CL in the phenylpropanoid biosynthesis pathway were upregulated in roots and leaves. In the salicylic acid signal transduction pathway, TGA7 was upregulated in the roots and leaves, while in the jasmonic acid signal transduction pathway, TIFY9 was upregulated in the roots and leaves. In the ion transporter gene, we identified HKT1 that showed identical expression patterns in the roots and leaves. The impact of NaCl imposition for 12 h was largely due to osmotic effect of salinity on C. grandiflora, and most likely the transcript abundance changes in this study were due to the osmotic effect. In order to verify the accuracy of the Illumina sequencing data, we selected 16 DEGs for transcription polymerase chain reaction (qRT-PCR) analysis. qRT-PCR and transcriptome sequencing analysis revealed that the transcriptome sequencing results were reliable.
COVID-19 in Kidney Transplant Recipients: A Multicenter Experience from the First Two Waves of Pandemic
Authors: Demir Erol , Ucar Zuhal Atan , Dheir Hamad , Danis Ramazan , Yelken Berna , Uyar Murathan , Parmaksiz Ergun , Artan Ayse Serra , Sinangil Ayse , Merhametsiz Ozgur , Yadigar Serap , Dirim Ahmet Burak , Akin Baris , Garayeva Nurana , Safak Seda , Turkmen Aydin
Published: May 2022

Background

Kidney transplant recipients have an increased risk of complications from COVID-19. However, data on the risk of allograft damage or death in kidney transplant recipients recovering from COVID-19 is limited. In addition, the first and second waves of the pandemic occurred at different times all over the world. In Turkey, the Health Minister confirmed the first case in March 2020; after that, the first wave occurred between March and August 2020; afterward, the second wave began in September 2020. This study aims to demonstrate the clinical presentations of kidney transplant recipients in the first two waves of the pandemic in Turkey and explore the impact of COVID-19 on clinical outcomes after the initial episode.

Methods

Patients with COVID-19 from seven centers were included in this retrospective cohort study. Initially, four hundred and eighty-eight kidney transplant recipients diagnosed with COVID-19 between 1 March 2020 to 28 February 2021 were enrolled. The endpoints were the occurrence of all-cause mortality, acute kidney injury, cytokine storm, and acute respiratory distress syndrome. In addition, longer-term outcomes such as mortality, need for dialysis, and allograft function of the surviving patients was analyzed.

Results

Four hundred seventy-five patients were followed up for a median of 132 days after COVID-19. Forty-seven patients (9.9%) died after a median length of hospitalization of 15 days. Although the mortality rate (10.1% vs. 9.8%) and intensive care unit admission (14.5% vs. 14.5%) were similar in the first two waves, hospitalization (68.8% vs. 29.7%; p < 0.001), acute kidney injury (44.2% vs. 31.8%; p = 0.009), acute respiratory distress syndrome (18.8% vs. 16%; p = 0.456), and cytokine storm rate (15.9% vs. 10.1%; p = 0.072) were higher in first wave compared to the second wave. These 47 patients died within the first month of COVID-19. Six (1.4%) of the surviving patients lost allografts during treatment. There was no difference in the median serum creatinine clearance of the surviving patients at baseline (52 mL/min [IQR, 47–66]), first- (56 mL/min [IQR, 51–68]), third- (51 mL/min [IQR,48–67]) and sixth-months (52 mL/min [IQR, 48–81]). Development of cytokine storm and posttransplant diabetes mellitus were independent predictors for mortality.

Conclusions

Mortality remains a problem in COVID-19. All the deaths occur in the first month of COVID-19. Also, acute kidney injury is common in hospitalized patients, and some of the patients suffer from graft loss after the initial episode.
Dent-2 disease with a Bartter-like phenotype caused by the Asp631Glu mutation in the OCRL gene
Authors: Drosataki Eleni , Maragkou Sevasti , Dermitzaki Kleio , Stavrakaki Ioanna , Lygerou Dimitra , Latsoudis Helen , Pleros Christos , Petrakis Ioannis , Zaganas Ioannis , Stylianou Kostas
Published: May 2022

Background

Dent disease is an X-linked disorder characterized by low molecular weight proteinuria (LMWP), hypercalciuria, nephrolithiasis and chronic kidney disease (CKD). It is caused by mutations in the chloride voltage-gated channel 5 (CLCN5) gene (Dent disease-1), or in the OCRL gene (Dent disease-2). It is associated with chronic metabolic acidosis; however metabolic alkalosis has rarely been reported.

Case presentation

We present a family with Dent-2 disease and a Bartter-like phenotype. The main clinical problems observed in the proband included a) primary phosphaturia leading to osteomalacia and stunted growth; b) elevated serum calcitriol levels, leading to hypercalcemia, hypercalciuria, nephrolithiasis and nephrocalcinosis; c) severe salt wasting causing hypotension, hyperaldosteronism, hypokalemia and metabolic alkalosis; d) partial nephrogenic diabetes insipidus attributed to hypercalcemia, hypokalemia and nephrocalcinosis; e) albuminuria, LMWP.

Phosphorous repletion resulted in abrupt cessation of hypercalciuria and significant improvement of hypophosphatemia, physical stamina and bone histology. Years later, he presented progressive CKD with nephrotic range proteinuria attributed to focal segmental glomerulosclerosis (FSGS). Targeted genetic analysis for several phosphaturic diseases was unsuccessful. Whole Exome Sequencing (WES) revealed a c.1893C > A variant (Asp631Glu) in the OCRL gene which was co-segregated with the disease in male family members.

Conclusions

We present the clinical characteristics of the Asp631Glu mutation in the OCRL gene, presenting as Dent-2 disease with Bartter-like features. Phosphorous repletion resulted in significant improvement of all clinical features except for progressive CKD. Angiotensin blockade improved proteinuria and stabilized kidney function for several years.

Graphical abstract
Cardiovascular risk factors and breast cancer incidence in a large middle-aged cohort study
Authors: Zeng Xiaoqi , Jiang Shanshan , Ruan Simin , Zhu Lijun , Lian Huining , Liu Minfeng , Guo Zhaoze , Guo Jingyun , Ye Changsheng , Cheng Yunjiu , Dong Jianyu
Published: May 2022

Background

Several studies have demonstrated that cardiovascular risk factors play a role in the etiology of breast cancer. However, the combined effect of cardiovascular risk factors on the risk of breast cancer is still uncertain.

Methods

Data from the Atherosclerosis Risk in Communities (ARIC) study, a prospective cohort of middle-aged women, were used to investigate the association of individual and combined cardiovascular risk factors with breast cancer. Cox proportional hazards models were applied to calculate the hazard ratio (HR) and 95% confidence intervals (CI).

Results

A total of 7501 women were included. During a mean follow-up of 19.7 years, 576 women were diagnosed with breast cancer. White women and premenopausal status were independently associated with increased risk of breast cancer. Of the individual cardiovascular risk factors, only obesity was independently associated with an increased risk of breast cancer (HR 1.29, 95% CI 1.04–1.61). Compared with women without cardiovascular risk factors, women having three or greater, but not those with fewer than three cardiovascular risk factors, had a significantly higher risk of developing breast cancer (HR 1.27, 95% CI 1.06–1.53). Subgroup analyses indicated that women with three or greater cardiovascular risk factors had higher risk of breast cancer among postmenopausal Black women, but not among premenopausal Black and White women.

Conclusions

Combinations of cardiovascular risk factors are associated with increased risk of breast cancer in middle-aged women, especially in postmenopausal Black women. Joint interventions to modify cardiovascular risk factors could be used to prevent breast cancer in these higher-risk individuals.
Long-term follow-up of retinal morphology and physiology after 2000 mg sildenafil overdose as a means of attempted suicide: a case report
Authors: Miura Gen , Baba Takayuki , Hashimoto Ryusuke , Yamamoto Shuichi
Published: May 2022

Background

Few case reports have described sildenafil overdose, particularly ingestion of > 1000 mg, and overdose-induced changes in visual function remain unclear. We report retinal morphology, retinal sensitivity, and findings of electrophysiological evaluation over long-term follow-up in a case of sildenafil overdose (2000 mg).

Case presentation

Our patient developed visual abnormalities in the paracentral visual field accompanied by photophobia, decreased contrast sensitivity, and difficulty distinguishing colors in both eyes, 8 hours after the sildenafil overdose. These symptoms did not improve throughout the course, and although abnormalities of retinal morphology and sensitivity, as well as the electroretinogram findings showed slight improvement, the patient did not recover completely at 6-month follow-up.

Conclusions

We observed that high-dose sildenafil ingestion leads to retinal toxicity; the ocular abnormalities may persist for at least 6 months. Optical coherence tomography, Humphrey perimetry, microperimetry, and multifocal electroretinography are useful to quantitatively monitor temporal changes.
Effects of optic nerve head-related parameters on retinal vessel calibers measurement results on fundus photographs
Authors: Iwase Aiko , Tsutsumi Tae , Kawasaki Ryo , Suehiro Jun , Sekine Akihiko , Araie Makoto
Published: May 2022

Background

Although relationship between the retinal vessel caliber (RVC) and glaucoma is well known, there has been a paucity of information on the effects of glaucoma-related optic nerve head (ONH) structural factors on the RVC. Information on this relationship should be useful in studying possible roles of ocular circulation in the development and progression of glaucoma.

Method

Subjects were from Kumejima Study participants aged 40 years and older in Kumejima, Japan. Normal subjects and eyes were defined according to standardized systemic and ocular examinations. The central retinal artery and vein equivalents (CRAE and CRVE) were determined on fundus photographs by correcting the magnification using the refractive error, corneal curvature, and axial length (AL) of an individual eye and paraxial ray tracing; the ONH structural parameters were determined by planimetry.

Results

In a total of 558 right eyes (558 normal subjects), aged 49.0 ± 7.1 (standard deviation) years with gradable photographs and planimetric results, CRAE averaged 136.1 ± 12.3 μm and CRVE 216.9 ± 17.4 μm. After adjustment for the effects of confounding factors in multivariate analysis, the AL (P < 0.001), rim area (P = 0.019), disc area (P = 0.042), and smoking (P = 0.035–0.043) correlated positively, and the mean blood pressure (P < 0.001) negatively with CRAE; the AL (P < 0.001), rim area (P = 0.001), disc area (P = 0.005), smoking (P < 0.001), and male sex (P = 0.013) correlated positively, and the β-peripapillary atrophy (β-PPA) area (P = 0.044), vertical Cup/Disc ratio (v-C/D) (P = 0.035), and age (P < 0.001) negatively with CRVE.

Conclusion

The current study showed significant effects of rim area, v-C/D or β-PPA area determined on the photographs on the RVC measurement results. Further, it showed a necessity to incorporate the glaucoma-related ONH structural parameters as co-variables to correctly estimate the effects of various factors on the RVC.
For there is nothing either good or bad: a study of the mediating effect of interpretation bias on the association between mindfulness and reduced post-traumatic stress vulnerability
Authors: Deen Hannah , Notebaert Lies , Van Bockstaele Bram , Clarke Patrick J. F. , Todd Jemma
Published: May 2022

Background

Despite increasing interest in the association between mindfulness and reduced trauma vulnerability, and the use of mindfulness in the latest interventions for Post-Traumatic Stress Disorder (PTSD), few studies have examined the mechanisms through which mindfulness may influence post-trauma psychopathology. The present study aimed to determine whether negative interpretation bias, the tendency to interpret ambiguous information as negative or threatening rather than positive or safe, mediates the association between higher levels of trait mindfulness and lower levels of PTSD symptoms. Negative interpretation bias was examined due to prior evidence indicating it is associated with being less mindful and post trauma psychopathology.

Methods

The study examined 133 undergraduate students who reported exposure to one or more potentially traumatic events in their lifetime. Participants completed self-report measures of trait mindfulness (Five Facet Mindfulness Questionnaire – Short Form; FFMQ-SF) and PTSD symptoms (Post-Traumatic Stress Disorder Checklist – Civilian version; PCL-C) as well an interpretation bias task that assessed the degree to which participants interpreted a range of everyday hypothetical scenarios to be threatening to their physical and/or psychological wellbeing.

Results

Results of a mediation analysis indicated a significant negative direct effect of trait mindfulness on PTSD symptomatology (p < .001). There was no evidence that negative interpretation bias mediated this relationship [BCa CI [-0.04, 0.03)], nor was it associated with trait mindfulness (p = .90) and PTSD symptomatology (p = .37).

Conclusions

The results of the current study provide further evidence of the link between trait mindfulness and reduced post-trauma psychopathology while providing no support for the role of negative interpretation bias in this relationship.
The positive effects of parents’ education level on children’s mental health in Indonesia: a result of longitudinal survey
Authors: Fakhrunnisak Dian , Patria Bhina
Published: May 2022

Background

Mental health problems are associated with decreasing the quality of various aspects of life. Cases of mental health problems (e.g., depressive symptoms) have increased continuously. Researchers predicted depression to be the first cause of world burden diseases in 2030. One of the determinant factors of mental health is parents’ education levels, but there have been contradictory research findings. The current research investigates the effect parental education attainment has on children’s mental health.

Methods

We used public data from two waves of the Indonesia Family Life Survey (IFLS) conducted in 2007 and 2014. There were 767 participants aged 15-19 years old (M = 16.80, SD = 1.37) in 2007. All participants were re-interviewed in 2014. We examined the highest level of the parents’ formal education in 2007 and the children’s mental health in 2014 to find the longitudinal effects. We used depressive symptoms and happiness as representative variables of mental health. The structural equation model (SEM) was used to examine the hypothesis, and we prioritized predictive testing over the models’ goodness of fit. We have built 12 models of combinations of children’s and parents’ sexes and different independent variables.

Results

The hypothesis testing showed the longitudinal effects that fathers’ education in 2007 has on daughters’ depressive symptoms in 2014 (β = −.203, p < 0.01), while there were longitudinal effects from mothers’ education in 2007 on their daughters’ depressive symptoms (β = −.163, p < 0.01) and sons’ depressive symptoms (β = .096, p ≤ 0.05) in 2014. Testing the happiness models showed that fathers’ education in 2007 influenced the happiness of all of participants (β = .167, p < 0.01), including both sons (β = .206, p < 0.01) and daughters (β = 149, p < 0.01). On the contrary, no significant correlation was found between mothers’ education and children’s happiness across all three categories of participants.

Conclusions

The general results of this study showed that parents’ education levels were associated with their children’s mental health, but there are different associations found through the different combinations of children’s and parents’ sexes.
Application of the induced membrane technique of tibia using extracorporeal vs. intracorporeal formation of a cement spacer: a retrospective study
Authors: Luo Junhao , Bo Fanyu , Wang Jian , Wu Yongwei , Ma Yunhong , Yin Qudong , Liu Yu
Published: May 2022

Background

There were two ways of preparing the cement spacer: intracorporeal and extracorporeal formation. This study aimed to investigate the outcomes of extracorporeal vs. intracorporeal formation of a spacer using the induced membrane technique (IMT) for repairing bone defects of the tibia.

Methods

Sixty-eight patients with tibial defects treated with IMT were analyzed retrospectively. According to the mode of bone cement preparation, patients were divided into intracorporeal and extracorporeal groups (36 vs. 32 respectively). All patients were followed up for 12–48 months (average 18.7 months). The time interval between the first and second stages, the time required to remove the spacer, injury of the IM or bone ends, bone healing and infection control, as well as the functional recovery (Johner—Wruhs scoring), were compared.

Results

There was no significant difference in the preoperative data between the two groups (P > 0.05). There was no significant difference in the time interval (12.64 ± 4.41vs. 13.22 ± 4.96 weeks), infection control (26/28 vs. 20/23), bone healing time (7.47 ± 2.13vs. 7.50 ± 2.14 mos), delayed union (2/36 vs. 2/32), nonunion (2/36 vs. 1/32), an excellent or good rate of limb functional recovery (30/36 vs. 26/32) between the intracorporeal and extracorporeal groups (P > 0.05). However, the time required to remove (3.97 ± 2.34 min) was longer and the injury of IM or bone ends (28/36) was greater in the intracorporeal group than those in the extracorporeal group (0.56 ± 0.38 min and 1/32, respectively), showing a significant difference (P < 0.05).

Conclusion

Both approaches were shown to have similar effects on bone defect repair and infection control. However, intracorporeal formation had advantages in terms of additional stability, while extracorporeal formation had advantages in terms of removal. Therefore, the specific method should be selected according to specific clinical needs. We recommended the extracorporeal or the modified extracorporeal formation in most cases.
Non-operative treatment or volar locking plate fixation for dorsally displaced distal radius fractures in patients over 70 years – a three year follow-up of a randomized controlled trial
Authors: Südow Hanna , Severin Sara , Wilcke Maria , Saving Jenny , Sköldenberg Olof , Navarro Cecilia Mellstrand
Published: May 2022

Background

Surgical treatment of displaced distal radius fractures (DRF) in older patients has increased, despite lacking evidence of its superiority over non-operative treatment. How treatment choice affects these patients after the initial 12-month period remains unknown. This study presents a clinical and radiographic follow up at an average of 3 years after treatment in the context of a randomized clinical trial comparing outcomes in patients aged ≥70 years, with a dorsally displaced distal radius fracture treated either surgically with volar locking plate or non-operatively.

Methods

Between 2009 and 2017, 140 patients aged ≥70 years with dorsally displaced DRF were randomized to surgery with volar locking plate (VLP) or non-operative treatment. At an average of 3 years after inclusion the participants were invited to an additional follow-up. The primary outcome was Patient Rated Wrist Evaluation (PRWE). Secondary outcomes included additional Patient Reported Outcome Measures (PROM), grip strength, range of motion, complications and radiological results.

Results

Sixty six patients were available for a 3 year follow-up, 33 in the non-operatively treated group and 33 in the VLP-group. The mean age at injury was 77 years. At 3 years the median PRWE was better (0 points) in the VLP-group than in the non-operative treatment group (9 points) p-value: 0.027. No statistically significant difference was found in Disabilities of the Arm, Hand, and Shoulder (DASH), EuroQol 5 Dimensions (EQ-5D) or grip strength. Total arc of range of motion was larger in the operatively treated group. No significant difference in osteoarthritis was found. Both groups had regained grip strength. The complication rate was similar. Outcomes improved from the 1 year to the 3 year follow-up.

Conclusions

Surgery with volar locking plate gave less long-term disability compared to non-operative treatment for severely displaced distal radius fractures in patients aged ≥70 years. Our findings were statistically significant but in the lower range of clinical importance.

Trial registration

The study was registered at : NCT02154620 03/06/2014 and NCT01268397 30/12/2010. Ethical approval was obtained from Ethical Committee in Stockholm, Sweden (2009/37–31/3, 2013/105–31/2, 2014/1041–32, 2017/611–32).
Correlation and comparison of quadriceps endurance and knee joint position sense in individuals with and without unilateral knee osteoarthritis
Authors: Saeed Alshahrani Mastour , Reddy Ravi Shankar , Asiri Faisal , Tedla Jaya Shanker , Alshahrani Adel , Kandakurti Praveen Kumar , Kakaraparthi Venkata Nagaraj
Published: May 2022

Background

Knee osteoarthritis (KOA) is a painful degenerative joint disease that may limit activities of daily living. This study aimed to determine the relationship between quadriceps endurance and knee joint position sense (JPS) in KOA individuals and compare the quadriceps endurance and knee JPS with and without KOA.

Methods

This comparative cross-sectional study was conducted in medical rehabilitation clinics, King Khalid University, Saudi Arabia. This study recruited 50 individuals diagnosed with unilateral KOA (mean age = 67.10 ± 4.36 years) and 50 asymptomatic individuals (mean age = 66.50 ± 3.63 years). Quadriceps isometric endurance capacity (sec) was measured using a fatigue resistance test, and knee JPS (degrees) were assessed using a digital inclinometer and evaluated in sitting and standing positions.

Results

Quadriceps isometric endurance showed a significant moderate negative correlation with knee JPS in 20° of flexion (r = -0.48, p < 0.001); 40° of flexion: r = -0.62, p < 0.001; 60° of flexion: r = -0.58, p < 0.001) in sitting and 20° of flexion (r = -0.25, p = 0.084) in standing position in KOA individuals. When compared to the asymptomatic, the quadriceps endurance was lower (p < 0.001), and knee joint position errors were larger (p < 0.001) in KOA individuals.

Conclusion

Results of this study showed that quadriceps endurance capacity is negatively associated with knee JPS. KOA individuals demonstrated lower quadriceps endurance and larger JPS compared to asymptomatic.
Role of protective stoma after primary anastomosis for generalized peritonitis due to perforated diverticulitis—DIVERTI 2 (a prospective multicenter randomized trial): rationale and design (nct04604730)
Authors: Pinson Jean , Tuech Jean-Jacques , Ouaissi Mehdi , Mathonnet Murielle , Mauvais François , Houivet Estelle , Lacroix Elie , Rondeaux Julie , Sabbagh Charles , Bridoux Valérie
Published: May 2022

Background

Traditionally, patients with peritonitis Hinchey III and IV due to perforated diverticulitis were treated with Hartmann’s procedure. In the past decade, resection and primary anastomosis have gained popularity over Hartmann’s procedure and recent guidelines recommend Hartmann’s procedure in two situations only: critically ill patients and in selected patients with multiple comorbidity (at high risk of complications).

The protective stoma (PS) is recommended after resection with primary anastomosis, however its interest has never been studied. The aim of this trial is to define the role of systematic PS after resection and primary anastomosis for peritonitis Hinchey III and IV due to perforated diverticulitis.

Methods/design

This DIVERTI 2 trial is a multicenter, randomized, controlled, superiority trial comparing resection and primary anastomosis with (control group) or without (experimental group) PS in patients with peritonitis Hinchey III and IV due to perforated diverticulitis.

Primary endpoint is the overall 1 year morbidity according to the Clavien–Dindo classification of surgical complications. All complications occurring during hospitalization will be collected. Late complications occurring after hospitalization will be collected during follow-up.

In order to obtain 80% power for a difference given by respective main probabilities of 67% and 47% in the protective stoma and no protective stoma groups respectively, with a two-sided type I error of 5%, 96 patients will have to be included in each group, hence 192 patients overall. Expecting a 5% rate of patients not assessable for the primary end point (lost to follow-up), 204 patients will be enrolled.

Secondary endpoints are postoperative mortality, unplanned reinterventions, incisional surgical site infection (SSI), organ/space SSI, wound disruption, anastomotic leak, operating time, length of hospital stay, stoma at 1 year after initial surgery, quality of life, costs and quality-adjusted life years (QALYs).

Discussion

The DIVERTI 2 trial is a prospective, multicenter, randomized, study to define the best strategy between PS and no PS in resection and primary anastomosis for patients presenting with peritonitis due to perforated diverticulitis.

Trial registration

ClinicalTrial.gov: NCT04604730 date of registration October 27, 2020. https://clinicaltrials.gov/ct2/show/NCT04604730?recrs=a&cond=Diverticulitis&draw=2&rank=12.
Germany-wide evaluation of residency in neurological intensive care medicine
Authors: Ernst Ann-Kathrin , Zupanic Michaela , Ellrichmann Gisa , Biesalski Anne-Sophie
Published: May 2022

Background

Neurointensive medicine is an important subspecialization of neurology. Its growing importance can be attributed to factors such as demographic change and the establishment of new therapeutic options. Part of the neurological residency in Germany is a six-month rotation on an intensive care unit (ICU), which has not yet been evaluated nationwide. The aim of this study was to evaluate kind and feasibility of neurointensive care training in Germany and to discover particularly successful training concepts.

Methods

In a preliminary study, ten residents and ten instructors were interviewed. Using content analysis, two questionnaires were created, which contained questions about specific teaching methods as well as individual satisfaction. The questionnaires were sent to 187 neurological clinics in Germany, and residents and instructors were asked to participate in the study. The data analysis was performed using SPSS and content analysis for the free-text data.

Results

Seventy of the 187 clinics contacted did not offer ICU-rotation. At 59,8% (n = 70) of the remaining hospitals, a total of 154 participants (84 residents, 70 educators) could be recruited. General satisfaction with the neurointensive medical training is high in both groups (residents: 3.34 ± 0.54; instructors: 3.79 ± 0.41, evaluated on the basis of a Likert scale from 1 = “not satisfied” to 5 = "fully satisfied"). Specific teaching methods (e.g. simulation trainings, feedback sessions) are perceived as very useful by residents, but rarely take place. Instructors are interested in educational opportunities such as didactic courses.

Conclusion

This study provides an overview of the ICU-rotation as part of the five-year neurological residency. Neurointensive care rotations usually take place at maximum care hospitals and last at least seven months. Despite frequent time and personnel restrictions, motivation of trainers and residents is high. Nevertheless, teaching methods as simulation training and educational opportunities for instructors must be expanded.
Development of a machine learning model to predict mild cognitive impairment using natural language processing in the absence of screening
Authors: Penfold Robert B. , Carrell David S. , Cronkite David J. , Pabiniak Chester , Dodd Tammy , Glass Ashley MH , Johnson Eric , Thompson Ella , Arrighi H. Michael , Stang Paul E.
Published: May 2022

Background

Patients and their loved ones often report symptoms or complaints of cognitive decline that clinicians note in free clinical text, but no structured screening or diagnostic data are recorded. These symptoms/complaints may be signals that predict who will go on to be diagnosed with mild cognitive impairment (MCI) and ultimately develop Alzheimer’s Disease or related dementias. Our objective was to develop a natural language processing system and prediction model for identification of MCI from clinical text in the absence of screening or other structured diagnostic information.

Methods

There were two populations of patients: 1794 participants in the Adult Changes in Thought (ACT) study and 2391 patients in the general population of Kaiser Permanente Washington. All individuals had standardized cognitive assessment scores. We excluded patients with a diagnosis of Alzheimer’s Disease, Dementia or use of donepezil. We manually annotated 10,391 clinic notes to train the NLP model. Standard Python code was used to extract phrases from notes and map each phrase to a cognitive functioning concept. Concepts derived from the NLP system were used to predict future MCI. The prediction model was trained on the ACT cohort and 60% of the general population cohort with 40% withheld for validation. We used a least absolute shrinkage and selection operator logistic regression approach (LASSO) to fit a prediction model with MCI as the prediction target. Using the predicted case status from the LASSO model and known MCI from standardized scores, we constructed receiver operating curves to measure model performance.

Results

Chart abstraction identified 42 MCI concepts. Prediction model performance in the validation data set was modest with an area under the curve of 0.67. Setting the cutoff for correct classification at 0.60, the classifier yielded sensitivity of 1.7%, specificity of 99.7%, PPV of 70% and NPV of 70.5% in the validation cohort.

Discussion and conclusion

Although the sensitivity of the machine learning model was poor, negative predictive value was high, an important characteristic of models used for population-based screening. While an AUC of 0.67 is generally considered moderate performance, it is also comparable to several tests that are widely used in clinical practice.
Acceptance of COVID-19 vaccine and determinant factors in the Iranian population: a web-based study
Authors: Omidvar Shabnam , Firouzbakht Mojgan
Published: May 2022

Background

Iran had a high rate of death in several COVID 19 waves. Vaccination is a method for prevention and control of the COVID-19 pandemic. Success in controlling the pandemic is not solely dependent on the effectiveness of the vaccines. It is also dependent on the global acceptance and vaccine coverage rate. This study aimed to determine the acceptance rate of COVID-19 vaccination in the Iranian population and the factors affecting it.

Methods and materials

This study was a cross-sectional research on 1564 Iranian people above 18. Study data were collected using a web-based questionnaire and analyzed using linear regression analysis and logistics at a significance level of 0.05 using SPSS.

Results

Approximately 70% of the participants reported acceptance of the vaccines. Ten percent of the people were against and 20% were hesitant to get vaccinated. The results showed that risk perception (P = .003), Knowledge of the disease (P < .001), trust in the health system (P < .001), attitude towards vaccination (P < .001), and vaccination literacy (P < .001) were predictors of vaccine acceptance. People with higher levels of education and mistrust towards the health system had a reduced vaccine acceptance rate.

Conclusions

The acceptance rate of the COVID-19 vaccine in Iran was higher than in the other countries in the Middle East. Extensive interventions are important to increase the trust in the health system and improve the knowledge of vaccine efficacy and literacy.
Documenting response to COVID-individual and systems successes and challenges: a longitudinal qualitative study
Authors: Shaukat Natasha , Ali Daniyal Mansoor , Barolia Rubina , Hisam Butool , Hassan Sheza , Afzal Badar , Khan Abdus Salam , Angez Meher , Razzak Junaid
Published: May 2022

Background

This study aimed to document the evolution of perceptions of frontline healthcare workers (FHCW) regarding their well-being and the quality of health systems' response to the COVID-19 pandemic over four months in Pakistan.

Methods

We conducted this prospective longitudinal qualitative study during the four months (June–September 2020) coinciding with the peak and trough of the first wave of Pakistan's COVID-19 pandemic. We approached frontline healthcare workers (physicians and nurses) working in emergency departments (ED) in two hospitals using the WhatsApp group of the Pakistan Society of Emergency Physicians (PSEM). Participants were asked to self-record their perception of their wellness and their level of satisfaction with the quality of their hospitals' response to the pandemic. We transcribed, translated, and analysed manually using MAXQDA 2020 software and conducted the thematic analysis to identify themes and sub-themes.

Results

We invited approximately 200 FHCWs associated with PSEM to participate in the study. Of the 61 who agreed to participate, 27 completed the study. A total of 149 audio recordings were received and transcribed. Three themes and eight sub-themes have emerged from the data. The themes were individual-level challenges, health system-level challenges, and hope for the future. Sub-themes for individual-level challenges were: fear of getting or transmitting infection, feeling demotivated and unappreciated, disappointment due to people’s lack of compliance with COVID-19 protocols, physical exhaustion, and fatigue. For the healthcare system, sub-themes were: Infrastructure, logistics, management, and communications response of the hospital/healthcare system and financial stressors. For sub-themes under hope for the future were the improved disease knowledge and vaccine development. The overall perceptions and experiences of FHCWs evolved from fear, grief, and negativity to hope and positivity as the curve of COVID-19 went down.

Conclusion

This study shows that the individuals and systems were not prepared to deal with the challenges of the COVID-19 pandemic. The findings highlight the challenges faced by individuals and health systems during the wake of the Covid-19 pandemic. The healthcare workers were emotionally and physically taxed, while the health systems were overwhelmed by COVID-19. The overall perceptions of FHCWs evolved with time and became negative to positive as the curve of COVID-19 went down during the first wave of COVID-19 in Pakistan.
Serotonin modulates insect gut bacterial community homeostasis
Authors: Zeng Tian , Su Hong-ai , Liu Ya-lan , Li Jian-fang , Jiang Ding-xin , Lu Yong-yue , Qi Yi-xiang
Published: May 2022

Background

Metazoan guts are in permanent contact with microbial communities. However, the host mechanisms that have developed to manage the dynamic changes of these microorganisms and maintain homeostasis remain largely unknown.

Results

Serotonin (5-hydroxytryptamine [5-HT]) was found to modulate gut microbiome homeostasis via regulation of a dual oxidase (Duox) gene expression in both Bactrocera dorsalis and Aedes aegypti. The knockdown of the peripheral 5-HT biosynthetic gene phenylalanine hydroxylase (TPH) increased the expression of Duox and the activity of reactive oxygen species, leading to a decrease in the gut microbiome load. Moreover, the TPH knockdown reduced the relative abundance of the bacterial genera Serratia and Providencia, including the opportunistic pathogens, S. marcescens and P. alcalifaciens in B. dorsalis. Treatment with 5-hydroxytryptophan, a precursor of 5-HT synthesis, fully rescued the TPH knockdown-induced phenotype.

Conclusions

The findings reveal the important contribution of 5-HT in regulating gut homeostasis, providing new insights into gut–microbe interactions in metazoans.