bluuebunny/crossref_metadata_2025 huggingface dataset:
Factors Informing the Return of Adopted Dogs and Cats to an Animal Shelter
Authors: Hawes Sloane M. , Kerrigan Josephine M. , Hupe Tess , Morris Kevin N.
Published: September 2020

Although the adoption rate of dogs and cats from animal shelters has increased, a proportion of animals are returned to the shelter after they are adopted. The purpose of this study was to assess the factors informing the return of 102 dogs to an animal shelter over a four-month period, and the return of 72 cats to an animal shelter over a three-month period. Descriptive statistics revealed dogs are most commonly returned for behavior issues related to aggression (38.2%), and cats are most commonly returned due to the adopter’s personal reasons (56.9%). The results also indicated that more than half of the dogs (51.0%) and cats (57.0%) returned in this study were owned for more than 60 days. Further research is needed to compare the effectiveness of different pet retention programs in addressing the factors that inform returned adoptions.
Sex and Gender Differences in the Effects of Novel Psychoactive Substances
Authors: Fattore Liana , Marti Matteo , Mostallino Rafaela , Castelli Maria Paola
Published: September 2020

Sex and gender deeply affect the subjective effects and pharmaco-toxicological responses to drugs. Men are more likely than women to use almost all types of illicit drugs and to present to emergency departments for serious or fatal intoxications. However, women are just as likely as men to develop substance use disorders, and may be more susceptible to craving and relapse. Clinical and preclinical studies have shown important differences between males and females after administration of “classic” drugs of abuse (e.g., Δ9-tetrahydrocannabinol (THC), morphine, cocaine). This scenario has become enormously complicated in the last decade with the overbearing appearance of the new psychoactive substances (NPS) that have emerged as alternatives to regulated drugs. To date, more than 900 NPS have been identified, and can be catalogued in different pharmacological categories including synthetic cannabinoids, synthetic stimulants (cathinones and amphetamine-like), hallucinogenic phenethylamines, synthetic opioids (fentanyls and non-fentanyls), new benzodiazepines and dissociative anesthetics (i.e., methoxetamine and phencyclidine-derivatives). This work collects the little knowledge reached so far on the effects of NPS in male and female animal and human subjects, highlighting how much sex and gender differences in the effects of NPS has yet to be studied and understood.
Neoadjuvant Immune-Checkpoint Blockade in Triple-Negative Breast Cancer: Current Evidence and Literature-Based Meta-Analysis of Randomized Trials
Authors: Marinelli Daniele , Mazzotta Marco , Pizzuti Laura , Krasniqi Eriseld , Gamucci Teresa , Natoli Clara , Grassadonia Antonino , Tinari Nicola , Tomao Silverio , Sperduti Isabella , Sanguineti Giuseppe , Botticelli Andrea , Fabbri Agnese , Botti Claudio , Ciliberto Gennaro , Barba Maddalena , Vici Patrizia
Published: September 2020

Chemotherapy based on the sequential use of anthracyclines and taxanes has long represented the most efficacious approach in the management of early-stage, triple-negative breast cancer, whose aggressive behavior is widely renowned. This standard chemotherapy backbone was subsequently enriched by the use of carboplatin, based on its association with increased pathologic complete response and efficacy in the metastatic setting. Following the results from the IMpassion130 trial, the recent approval of the immunotherapic agent atezolizumab in combination with chemotherapy as first-line treatment for programmed-death ligand 1-positive, unresectable locally advanced, or metastatic triple-negative breast cancer increasingly fueled the flourishing of trials of immune-checkpoint inhibitors in the early setting. In this work, we review the most recent inherent literature in light of key methodological issues and provide a quantitative summary of the results from phase II–III randomized trials of immunotherapic agents combined with chemotherapy in the setting of interest. Hints regarding future directions are also discussed.
Drug Vulnerabilities and Disease Prognosis Linked to the Stem Cell-Like Gene Expression Program Triggered by the RHO GTPase Activator VAV2 in Hyperplastic Keratinocytes and Head and Neck Cancer
Authors: Lorenzo-Martín Luis Francisco , Menacho-Márquez Mauricio , Bustelo Xosé R.
Published: September 2020

We have recently shown that VAV2, a guanosine nucleotide exchange factor that catalyzes the stimulation step of RHO GTPases, is involved in a stem cell-like (SCL) regenerative proliferation program that is important for the development and subsequent maintenance of the tumorigenesis of both cutaneous (cSCC) and head and neck squamous cell carcinomas (hnSCC). In line with this, we have observed that the levels of the VAV2 mRNA and VAV2-regulated gene signatures are associated with poor prognosis in the case of human papillomavirus-negative hnSCC patients. These results suggest that the SCL program elicited by VAV2 in those cells can harbor therapeutically actionable downstream targets. We have addressed this issue using a combination of both in silico and wet-lab approaches. Here, we show that the VAV2-regulated SCL program does harbor a number of cell cycle- and signaling-related kinases that are essential for the viability of undifferentiated keratinocytes and hnSCC patient-derived cells endowed with high levels of VAV2 activity. Our results also show that the VAV2-regulated SCL gene signature is associated with poor hnSCC patient prognosis. Collectively, these data underscore the critical role of this VAV2-regulated SCL program for the viability of both preneoplastic and fully transformed keratinocytes.
PI3K p110α Blockade Enhances Anti-Tumor Efficacy of Abemaciclib in Human Colorectal Cancer Cells
Authors: Lee Hyun Jung , Kim Kui-Jin , Sung Ji Hea , Nam Milang , Suh Koung Jin , Kim Ji-Won , Kim Se Hyun , Kim Jin Won , Kim Yu Jung , Lee Keun-Wook , Lee Jong Seok , Kim Jee Hyun
Published: September 2020

Targeting cell cycle regulation in colorectal cancer has not been fully evaluated. We investigated the efficacy of the CDK4/6 inhibitor, abemaciclib, and confirmed a synergistic interaction for PI3K p110α and CDK dual inhibition in colorectal cancer cell lines. Caco-2 and SNU-C4 cell lines were selected to explore the mechanism of action for and resistance to abemaciclib. In vitro and in vivo models were used to validate the anti-tumor activity of abemaciclib monotherapy and BYL719 combination therapy. Abemaciclib monotherapy inhibited cell cycle progression and proliferation in Caco-2 and SNU-C4 cells. CDK2-mediated Rb phosphorylation and AKT phosphorylation appeared to be potential resistance mechanisms to abemaciclib monotherapy. Abemaciclib/BYL719 combination therapy demonstrated synergistic effects regardless of PIK3CA mutation status but showed greater efficacy in the PIK3CA mutated SNU-C4 cell line. Growth inhibition, cell cycle arrest, and migration inhibition were confirmed as mechanisms of action for this combination. In an SNU-C4 mouse xenograft model, abemaciclib/BYL719 combination resulted in tumor growth inhibition and apoptosis with tolerable toxicity. Dual blockade of PI3K p110α and CDK4/6 showed synergistic anti-tumor effects in vivo and in vitro in human colorectal cancer cell lines. This combination could be a promising candidate for the treatment of patients with advanced colorectal cancer.
Distinct Clinical Characteristics in Young-Onset Pancreatic Neuroendocrine Tumor
Authors: Goksu Suleyman Yasin , Ozer Muhammet , Kazmi Syed Mohammad Ali , Sanford Nina Niu , Aguilera Todd A. , Ahn Chul , Hsiehchen David , Sanjeevaiah Aravind , Khosama Leticia , Bleeker Jonathan , Atiq Muslim , Beg Muhammad Shaalan
Published: September 2020

Background: We aimed to study the effect of socioeconomic differences and molecular characteristics on survival in patients with young-onset pancreatic neuroendocrine tumors (YOPNET) and typical-onset PNET (TOPNET). Methods: We identified the patients with YOPNET (<50 years) and TOPNET (≥50 years) who underwent definitive surgery diagnosed between 2004 and 2016 using the National Cancer Database. We evaluated overall survival (OS) using the Kaplan–Meier and Cox regression methods before and after propensity score matching. A publicly available genomic dataset was used to compare mutation frequencies among the two groups. Results: A total of 6259 patients with PNET were included, of which 27% were YOPNET. Patients with YOPNET were more likely to be Black, Hispanic, female, and have private insurance versus patients with TOPNET (all p < 0.001). Patients with YOPNET had a lower comorbidity score, but higher stage and tumor size (all p < 0.001). YOPNET was associated with a greater improved OS than TOPNET before and after propensity score matching (p < 0.001). On multivariable analysis, this survival difference persisted for YOPNET as an independent prognostic factor (unmatched p = 0.008; matched p = 0.01). For genomic analysis, patients with YOPNET had a lower rate of multiple endocrine neoplasia type-1 (MEN-1) mutation than patients with TOPNET (26% vs. 56%, p < 0.001). Conclusions: YOPNET represents a disease with distinct clinical features. Patients with YOPNET who underwent definitive surgery had better OS than patients with TOPNET despite having higher stage and tumor size. YOPNET also had lower rate of MEN-1 mutation.
Hypofractionated Radiotherapy for Anaplastic Thyroid Cancer: Systematic Review and Pooled Analysis
Authors: Oliinyk Dmytro , Augustin Teresa , Koehler Viktoria Florentine , Rauch Josefine , Belka Claus , Spitzweg Christine , Käsmann Lukas
Published: September 2020

Anaplastic thyroid carcinoma (ATC) is associated with a poor prognosis due to aggressive tumor growth and high treatment resistance. Hypofractionated treatment concepts may be more effective and less time consuming compared to normofractionated radiotherapy (RT). In this retrospective study, we aim to evaluate the outcome of hypofractionated regimens and perform a systematic review concerning hypofractionated RT and pooled analysis of this treatment modality. A systematic review using the MEDLINE/Pubmed and Cochrane databases was performed. Data from all eligible studies were extracted, and a pooled analysis of literature and our cohort (n = 60) was carried out to examine patient characteristics, toxicity, and outcomes of patients with ATC. As a result, median overall survival (OS) of the single center cohort was four (range 1–12) months. Survival rates at one, three, and six months were 82%, 55%, and 36%, respectively. In univariate analyses, multimodal treatment (p = 0.006) and gender (p = 0.04) were correlated with an improved OS. Six studies with a total number of 152 patients undergoing hypofractionated RT treatment were analyzed. The pooled analysis included four patient cohorts with 60 patients and showed median OS of 5.3 (range: 1–24) months. Multimodal treatment (p < 0.001) and a cumulative radiation dose ≥50 Gy in equivalent dose in 2 Gy fractions (EQD2) (p = 0.014) correlated with an improved OS. On multivariate analysis, multimodal treatment (p = 0.003, hazard ratio (HR): 0.636, 95% confidence interval (CI): 0.469–0.861) was an independent predictor for longer OS. After propensity score matching (PSM), hypofractionated RT appears to be non-inferior compared to normofractionated RT concerning OS. In conclusion, hypofractionated RT is effective with manageable toxicity. A dose escalation with ≥50 Gy (EQD2) correlated with a longer OS. Hypofractionated RT could be an integral part in multimodal treatment with a promising outcome.
Radioresistance in Glioblastoma and the Development of Radiosensitizers
Authors: Ali Md Yousuf , Oliva Claudia R. , Noman Abu Shadat M. , Allen Bryan G. , Goswami Prabhat C. , Zakharia Yousef , Monga Varun , Spitz Douglas R. , Buatti John M. , Griguer Corinne E.
Published: September 2020

Ionizing radiation is a common and effective therapeutic option for the treatment of glioblastoma (GBM). Unfortunately, some GBMs are relatively radioresistant and patients have worse outcomes after radiation treatment. The mechanisms underlying intrinsic radioresistance in GBM has been rigorously investigated over the past several years, but the complex interaction of the cellular molecules and signaling pathways involved in radioresistance remains incompletely defined. A clinically effective radiosensitizer that overcomes radioresistance has yet to be identified. In this review, we discuss the current status of radiation treatment in GBM, including advances in imaging techniques that have facilitated more accurate diagnosis, and the identified mechanisms of GBM radioresistance. In addition, we provide a summary of the candidate GBM radiosensitizers being investigated, including an update of subjects enrolled in clinical trials. Overall, this review highlights the importance of understanding the mechanisms of GBM radioresistance to facilitate the development of effective radiosensitizers.
Endothelial Basement Membrane Components and Their Products, Matrikines: Active Drivers of Pulmonary Hypertension?
Authors: Mutgan Ayse Ceren , Jandl Katharina , Kwapiszewska Grazyna
Published: September 2020

Pulmonary arterial hypertension (PAH) is a vascular disease that is characterized by elevated pulmonary arterial pressure (PAP) due to progressive vascular remodeling. Extracellular matrix (ECM) deposition in pulmonary arteries (PA) is one of the key features of vascular remodeling. Emerging evidence indicates that the basement membrane (BM), a specialized cluster of ECM proteins underlying the endothelium, may be actively involved in the progression of vascular remodeling. The BM and its steady turnover are pivotal for maintaining appropriate vascular functions. However, the pathologically elevated turnover of BM components leads to an increased release of biologically active short fragments, which are called matrikines. Both BM components and their matrikines can interfere with pivotal biological processes, such as survival, proliferation, adhesion, and migration and thus may actively contribute to endothelial dysfunction. Therefore, in this review, we summarize the emerging role of the BM and its matrikines on the vascular endothelium and further discuss its implications on lung vascular remodeling in pulmonary hypertension.
Photosynthetic Pigments Changes of Three Phenotypes of Picocyanobacteria Synechococcus sp. under Different Light and Temperature Conditions
Authors: Śliwińska-Wilczewska Sylwia , Konarzewska Zofia , Wiśniewska Kinga , Konik Marta
Published: September 2020

It is estimated that the genus Synechococcus is responsible for about 17% of net primary production in the Global Ocean. Blooms of these organisms are observed in tropical, subtropical and even temperate zones, and they have been recorded recently even beyond the polar circle. The long-term scenarios forecast a growing expansion of Synechococcus sp. and its area of dominance. This is, among others, due to their high physiological plasticity in relation to changing environmental conditions. Three phenotypes of the genus Synechococcus sp. (Type 1, Type 2, and Type 3a) were tested in controlled laboratory conditions in order to identify their response to various irradiance (10, 55, 100 and 145 µmol photons m−2 s−1) and temperature (15, 22.5 and 30 °C) conditions. The highest total pigment content per cell was recorded at 10 μmol photons m−2 s−1 at all temperature variants with the clear dominance of phycobilins among all the pigments. In almost every variant the highest growth rate was recorded for the Type 1. The lowest growth rates were observed, in general, for the Type 3a. However, it was recognized to be less temperature sensitive in comparison to the other two types and rather light-driven with the highest plasticity and adaptation potential. The highest amounts of carotenoids were produced by Type 2 which also showed signs of the cell stress even around 55 μmol photons m−2 s−1 at 15 °C and 22.5 °C. This may imply that the Type 2 is the most susceptible to higher irradiances. Picocyanobacteria Synechococcus sp. require less light intensity to achieve the maximum rate of photosynthesis than larger algae. They also tolerate a wide range of temperatures which combined together make them gain a powerful competitive advantage. Our results will provide key information for the ecohydrodynamical model development. Thus, this work would be an important link in forecasting future changes in the occurrence of these organisms in the context of global warming.
Size Effects of the Crystallite of ZSM-5 Zeolites on the Direct Catalytic Conversion of L-Lactic Acid to L, L-Lactide
Authors: Huang Qintong , Li Rui , Fu Guangying , Jiang Jiuxing
Published: September 2020

ZSM-5 zeolites are commonly used as a heterogeneous catalyst for reactions. Four ZSM-5 catalysts (with various crystallite sizes and a similar ratio of Si/Al) and their ball-milling/surface-poisoning derivates were used to convert L-lactic acid to L, L-lactide. The reaction products were analyzed by three independent analytical methods (i.e., Proton nuclear magnetic resonance (1H NMR), high-pressure liquid chromatography (HPLC), and chiral gas chromatography (GC)) for determining the L, L-lactide yield and L-lactic acid conversion. A clear size effect, i.e., smaller catalysts providing better performance, was observed. Further ball-milling/surface-poisoning experiments suggested that the size effect of the ZSM-5 catalysts originated from the diffusion-controlled nature of the reaction under the investigated conditions.
Non-Isothermal Crystallization Behavior of Poly(vinylidene fluoride) in Dialkyl Phthalate Diluents during Thermally Induced Phase Separation Process
Authors: Lin Yakai , Tang Yuanhui , Wang Lin , Wang Xiaolin
Published: September 2020

The non-isothermal crystallization behavior of poly(vinylidene fluoride) (PVDF) in dialkyl phthalate diluents during the thermally induced phase separation (TIPS) process was investigated by differential scanning calorimetry (DSC) at various cooling rates. Dialkyl phthalates with different alkyl chain-length, namely dimethyl phthalate (DMP), diethyl phthalate (DEP) and dibutyl phthalate (DBP), were used as the diluent. The effects of alkyl chain-length of dialkyl phthalate and cooling rate on the non-isothermal crystallization behavior as implied by the Avrami analysis modified by Jeziorny and Mo’s analysis were determined. The values of half-time, t1/2, and the parameters Zc and F(t), which characterized the kinetics of non-isothermal crystallization, showed that the crystallization rate increased with the increase of the alkyl chain-length of dialkyl phthalate due to the lower compatibility between PVDF and dialkyl phthalate. Moreover, the alkyl chain-length of dialkyl phthalate also has a great impact on the compact spherulitic structure of PVDF membranes prepared from different PVDF/dialkyl phthalate blends. With the decrease of the alkyl chain-length of dialkyl phthalate, the number of spherulites increased and the size of spherulites became smaller. This research thus not only proves the effects of alkyl chain-length of dialkyl phthalate on the non-isothermal crystallization behavior of PVDF, but also provides a systematic strategy to evaluate a single diluent during the TIPS process.
Coral Reef Recovery in the Mexican Caribbean after 2005 Mass Coral Mortality—Potential Drivers
Authors: Elías Ilosvay Xochitl E. , Contreras-Silva Ameris I. , Alvarez-Filip Lorenzo , Wild Christian
Published: September 2020

In 2005, an extreme heatwave hit the Wider Caribbean, followed by 13 hurricanes (including hurricanes Emily and Wilma) that caused significant loss in hard coral cover. However, the drivers of the potential recovery are yet to be fully understood. Based on recent findings in the literature of coral cover recovery in the Mexican Caribbean after the mass bleaching event and associated hurricanes in 2005, this study analyzed, through random-effects meta-analysis, the hard coral and macroalgae benthic development and potential drivers of change between 2005 and 2016 in the Mexican Caribbean. Therefore, we tested the relative effect of sea surface temperature (SST), chlorophyll-a water concentration, coastal human population development, reef distance to shore, and geographical location on both hard coral and macroalgae cover over time. Findings revealed increases of both hard coral (by 6%) and algae cover (by ca. 14%, i.e., almost three times the increase of corals) over 12 years. Although our findings confirm the partial coral recovery after the 2005 Caribbean mass coral mortality event, they also indicate rapid colonization of algae across the region. Surprisingly, only SST correlated negatively with changes in coral cover. Contrary to expectations, there was a significantly greater algae cover increase in the Central section of the Mexican Caribbean, which is characterized by a low population density. However, a constant discharge of nutrient-rich freshwater may have facilitated algae growth there. This study reports partial regional reef recovery, but it also indicates that local factors, particularly eutrophication, facilitate algae growth at a speed that is much faster than coral recovery.
Lagrangian Submanifolds of Symplectic Structures Induced by Divergence Functions
Authors: Favretti Marco
Published: September 2020

Divergence functions play a relevant role in Information Geometry as they allow for the introduction of a Riemannian metric and a dual connection structure on a finite dimensional manifold of probability distributions. They also allow to define, in a canonical way, a symplectic structure on the square of the above manifold of probability distributions, a property that has received less attention in the literature until recent contributions. In this paper, we hint at a possible application: we study Lagrangian submanifolds of this symplectic structure and show that they are useful for describing the manifold of solutions of the Maximum Entropy principle.
Pattern Recognition of DC Partial Discharge on XLPE Cable Based on ADAM-DBN
Authors: Li Zhe , Xu Yongpeng , Jiang Xiuchen
Published: September 2020

Pattern recognition of DC partial discharge (PD) receives plenty of attention and recent researches mainly focus on the static characteristics of PD signals. In order to improve the recognition accuracy of DC cable and extract information from PD waveforms, a modified deep belief network (DBN) supervised fine-tuned by the adaptive moment estimation (ADAM) algorithm is proposed to recognize the four typical insulation defects of DC cable according to the PD pulse waveforms. Moreover, the effect of the training sample set size on recognition accuracy is analyzed. Compared with naive Bayes (NB), K-nearest neighbor (KNN), support vector machine (SVM), and back propagation neural networks (BPNN), the ADAM-DBN method has higher accuracy on four different defect types due to the excellent ability in terms of the feature extraction of PD pulse waveforms. Moreover, the increase of training sample set size would lead to the increase of recognition accuracy within a certain range.
Performance Improvement of PWM Control Methods for Voltage Step-Down in Series Resonant DC–DC Converters
Authors: Sidorov Vadim , Chub Andrii , Vinnikov Dmitri
Published: September 2020

The paper is focused on galvanically isolated series resonant DC–DC converters (SRCs) with a low quality factor of the resonant tank. These converters provide input voltage regulation at fixed switching frequency and good power density. Different modulation methods at the fixed switching frequency enable the implementation of the voltage buck functionality in these converters. The SRC under study is considered as a step-up front-end DC–DC converter for the integration of renewable energy sources in DC microgrids. The paper evaluates the voltage buck performance of the SRC achieved by using different pulse-width modulation (PWM) methods including conventional PWM and shifted PWM. Moreover, the new PWM methods, i.e., the hybrid shifted PWM (HSPWM), improved shifted PWM (ISPWM), and hybrid PWM (HPWM), are proposed to overcome the disadvantages of the existing methods. They improve the power conversion efficiency in the buck mode by reducing the power losses in the semiconductor switches and the isolating transformer of the SRC. The proposed and the existing methods are benchmarked in terms of the components stresses and power conversion efficiency. The presented findings have been experimentally validated by the help of a 200 W prototype, which demonstrated the lowest power loss in the case of the HPWM.
Gain Scheduling Output Feedback Control for Vehicle Path Tracking Considering Input Saturation
Authors: Liu Chao , Zhao Weiqiang , Li Jie
Published: September 2020

This paper presents a gain scheduling output feedback control method to reduce driver workload and improve driving performance by considering input saturation. The driver–vehicle system model is developed by considering tire cornering stiffness uncertainties and different driver parameter uncertainties. Meanwhile, the input saturation is also considered in the driver-vehicle system. A quadratic Lyapunov function is designed to solve the optimization problem with uncertainties and input saturation. The results, which are based on the MATLAB-CarSim co-simulation platform, indicate that the robust controller not only improves the convergence rate of the state but also reduces the steering workload of the driver.
Performance of 3D Wave Field Modeling Using the Staggered Grid Finite Difference Method with General-Purpose Processors
Authors: Franczyk Anna , Gwiżdż Damian , Leśniak Andrzej
Published: September 2020

This paper aims to provide a quantitative understanding of the performance of numerical modeling of a wave field equation using general-purpose processors. In particular, this article presents the most important aspects related to the memory workloads and execution time of the numerical modeling of both acoustic and fully elastic waves in isotropic and anisotropic mediums. The results presented in this article were calculated for the staggered grid finite difference method. Our results show that the more realistic the seismic wave simulations that are performed, the more the demand for memory and the computational capacity of the computing environment increases. The results presented in this article allow the estimation of the memory requirements and computational time of wavefield modeling for the considered model (acoustic, elastic or anisotropic) so that their feasibility can be assessed in a given computing environment and within an acceptable time. Understanding the numerical modeling performance is especially important when graphical processing units (GPU) are utilized to satisfy the intensive calculations of three-dimensional seismic forward modeling.
Techno-Economic and Environmental Assessment of Biomass Gasification and Fischer–Tropsch Synthesis Integrated to Sugarcane Biorefineries
Authors: Bressanin Jéssica Marcon , Klein Bruno Colling , Chagas Mateus Ferreira , Watanabe Marcos Djun Barbosa , Sampaio Isabelle Lobo de Mesquita , Bonomi Antonio , Morais Edvaldo Rodrigo de , Cavalett Otávio
Published: September 2020

Large-scale deployment of both biochemical and thermochemical routes for advanced biofuels production is seen as a key climate change mitigation option. This study addresses techno-economic and environmental aspects of advanced liquid biofuels production alternatives via biomass gasification and Fischer–Tropsch synthesis integrated to a typical sugarcane distillery. The thermochemical route comprises the conversion of the residual lignocellulosic fraction of conventional sugarcane (bagasse and straw), together with eucalyptus and energy-cane as emerging lignocellulosic biomass options. This work promotes an integrated framework to simulate the mass and energy balances of process alternatives and incorporates techno-economic analyses and sustainability assessment methods based on a life-cycle perspective. Results show that integrated biorefineries provide greenhouse gas emission reduction between 85–95% compared to the fossil equivalent, higher than that expected from a typical sugarcane biorefinery. When considering avoided emissions by cultivated area, biorefinery scenarios processing energy-cane are favored, however at lower economic performance. Thermochemical processes may take advantage of the integration with the typical sugarcane mills and novel biofuels policies (e.g., RenovaBio) to mitigate some of the risks linked to the implementation of new biofuel technologies.
Influence of Slag Cement on the Permeability of Concrete for Biological Shielding Structures
Authors: Jóźwiak-Niedźwiedzka Daria , Dąbrowski Mariusz , Bogusz Karolina , Glinicki Michał A.
Published: September 2020

Durability of concrete designed for radiation shielding structures is an important issue in nuclear power plant safety. An investigation of the permeability of concrete containing heavyweight aggregates and water-bearing aggregates was performed with respect to gaseous and liquid media. Mix design was developed using Portland and slag cement, crushed magnetite and serpentine aggregate. The use of slag cement in concrete containing magnetite and serpentine aggregates resulted in the substantial improvement of the compressive strength in comparison with Portland cement concrete. The application of slag cement was found to reduce the chloride ingress, regardless of the special aggregate use. The coefficient of chloride migration was within the range 5 ÷ 8 × 10−12 m2/s and 17 ÷ 25 × 10−12 m2/s for slag cement concrete and Portland cement concrete, respectively. At the same time, the carbonation depth was increased twice for slag cement concrete in comparison to Portland cement concrete. However, the maximum carbonation depth after one year of exposure to 1% CO2 was only 14 mm for slag cement concrete, and 7 mm for reference concrete. The total pore volume evaluated using mercury intrusion porosimetry was influenced by the type of special aggregate used. It was shown that concrete with various contents of magnetite aggregate and slag cement achieved the smallest total pore volume. While serpentine coarse aggregate caused an increase in total pore volume in comparison to concrete with magnetite aggregate.
Nonlinear Optimization of Turbine Conjugate Heat Transfer with Iterative Machine Learning and Training Sample Replacement
Authors: Dutta Sandip , Smith Reid
Published: September 2020

A simple yet effective optimization technique is developed to solve nonlinear conjugate heat transfer. The proposed Nonlinear Optimization with Replacement Strategy (NORS) is a mutation of several existing optimization processes. With the improvements of 3D metal printing of turbine components, it is feasible to have film holes with unconventional diameters, as these holes are created while printing the component. This paper seeks to optimize each film hole diameter at the leading edge of a turbine vane to satisfy several optimum thermal design objectives with given design constraints. The design technique developed uses linear regression-based machine learning model and further optimizes with strategic improvement of the training dataset. Optimization needs cost and benefit criteria are used to base its decision of success, and cost is minimized with maximum benefit within given constraints. This study minimizes the coolant flow (cost) while satisfying the constraints on average metal temperature and metal temperature variations (benefits) that limit the useful life of turbine components. The proposed NORS methodology provides a scientific basis for selecting design parameters in a nonlinear design space. This model is also a potential academic tool to be used in thesis works without demanding extensive computing resources.
An Improvement of Output Power in Doubly Salient Permanent Magnet Generator Using Pole Configuration Adjustment
Authors: Sriwannarat Warat , Seangwong Pattasad , Lounthavong Vannakone , Khunkitti Sirote , Siritaratiwat Apirat , Khunkitti Pirat
Published: September 2020

The doubly salient permanent magnet (DSPM) machines are very attractive for low-speed power generation. In this work, we propose a design technique to improve the output power of the DSPM generator by an adjustment of pole configuration. The number of stator and rotor poles, split ratio, as well as the stator pole arc of the generator, were proposedly adjusted and optimized. The output characteristics of the generator including the magnetic flux linkage, electromotive force, harmonic, cogging torque, electromagnetic torque, output voltage and output power were analyzed through finite element analysis. The symmetrical magnetic field distribution of all generators was firstly verified. Then, the results indicated that this particular generator was optimized at 18 stator poles and 12 rotor poles, while the split ratio and the stator pole arc should be set as 0.78 and 6.15 degrees, respectively. The proposed optimal generator could provide a significant improvement in the output voltage and the output power compared to the conventional structure. The output power of 1.28 kW can be reached by the optimal structure, which was two times higher than that of the conventional structure. The physical explanation regarding to the structural modification was also given. The proposed design technique can be applied for improving the output power of the DSPM machines.
Design and Validation of a Questionnaire to Measure Future Spanish Teachers’ Perceptions of Cinema in Pre-School and Primary Education: Towards Active and Technological Learning
Authors: Lorenzo-Lledó Alejandro
Published: September 2020

State of the art: Cinema, because of the eclectic nature of art, technology and mass media, can be manifested as an educational tool in the classroom. In this sense, the educational possibilities detected in the cinema are numerous. The pre-service teacher education in the figure of the teacher determines their educational resources. Purpose: The general objective of this study is to design and validate an instrument to measure the perceptions of students of Pre-School Teacher Degree and Primary Teacher Degree in Spanish universities about cinema as a teaching resource in Pre-School and Primary Education. Design/methodology: For this purpose, a systematic and planned process was developed for the design and validation of the Percepciones sobre las potencialidades del cine como recurso didáctico en las aulas de Infantil y Primaria ((PECID) (perceptions about the potentialities of cinema as a didactic resource in pre-school and primary classrooms)) questionnaire. Main findings: The results obtained showed a good content validity of 25 items after an expert judgement. On the other hand, a reliability of the internal consistency of the instrument of 0.978 was obtained. Furthermore, a three-factor structure was confirmed through factor analysis. Conclusions: It is concluded that the PECID questionnaire is a valid and reliable instrument to measure the perceptions of future teachers in Spain about using cinema as a resource for future teaching.
Association between Family Histories of Thyroid Cancer and Thyroid Cancer Incidence: A Cross-Sectional Study Using the Korean Genome and Epidemiology Study Data
Authors: Byun Soo-Hwan , Min Chanyang , Choi Hyo-Geun , Hong Seok-Jin
Published: September 2020

This study assessed the association between thyroid cancer and family history. This cross-sectional study used epidemiological data from the Korean Genome and Epidemiology Study from 2001 to 2013. Among 211,708 participants, 988 were in the thyroid cancer group and 199,588 were in the control group. Trained interviewers questioned the participants to obtain their thyroid cancer history and age at onset. The participants were examined according to their age, sex, monthly household income, obesity, smoking, alcohol consumption, and past medical history. The adjusted odds ratios (95% confidence intervals) for the family histories of fathers, mothers, and siblings were 6.59 (2.05–21.21), 4.76 (2.59–8.74), and 9.53 (6.92–13.11), respectively, and were significant. The results for the subgroup analyses according to sex were consistent. The rate of family histories of thyroid cancer for fathers and siblings were not different according to the thyroid cancer onset, while that of mothers were higher in participants with a younger age at onset (<50 years old group, 11/523 [2.1%], p = 0.007). This study demonstrated that thyroid cancer incidence was associated with thyroid cancer family history. This supports regular examination of individuals with a family history of thyroid cancer to prevent disease progression and ensure early management.
Strength Conditioning Program to Prevent Adductor Muscle Strains in Football: Does it Really Help Professional Football Players?
Authors: Núñez Javier F. , Fernandez Ismael , Torres Alberto , García Sergio , Manzanet Pablo , Casani Pascual , Suarez-Arrones Luis
Published: September 2020

Coaches at the professional level are often concerned about negative side effects from testing and intensive resistance training periods, and they are not willing to base their training prescriptions on data obtained from semiprofessional or amateur football players. Consequently, the purpose of this study was to analyze the reliability and effectiveness of two adductor injury active prevention programs using the adductor/abductor ratio and deficit between legs, on the basis of adduction–abduction power output during the exercises proposed, in professional football players. Forty-eight professional football players undertook complementary strength training for the adductor and abductor muscles in their dominant and non-dominant legs, once or twice a week throughout the playing season. The volume of the session was determined by the adductor/abductor ratio and the deficit between legs in the last session training measured. The number and severity of muscle injuries per 1000 h of exposure were recorded. Both prevention programs showed a very low rate of adductor injury (0.27 and 0.07 injuries/1000 h) with mild-to-moderate severity, maintaining a balance in percentage asymmetry between dominant and non-dominant legs for adductor (10.37%) and in the adductor/abductor ratio (0.92) in top professional football players throughout the season. The strength conditioning program proposed can help to prevent adductor muscle injuries in top professional football players.
Do Daily Compensatory Health Beliefs Predict Intention to Quit and Smoking Behavior? A Daily Diary Study during Smoking Cessation
Authors: Amrein Melanie A. , Lüscher Janina , Berli Corina , Radtke Theda , Scholz Urte
Published: September 2020

Compensatory health beliefs (CHBs) are a means to cope with motivational conflicts between intended health goals and the temptation for an unhealthy behavior. As CHBs can fluctuate on a daily basis, this study examined how daily CHBs are associated with daily intention to quit smoking and daily number of cigarettes smoked before and after a quit date at the between- and within-person level. The study comprised a prospective longitudinal design and investigated 83 women and 83 men for 32 consecutive days during an ongoing joint self-set quit attempt. Daily CHBs varied from day to day and between individuals. At the between-person level, higher women’s mean CHBs were associated with lower intention (b = −0.23, p = 0.04) and at the 10% level with more cigarettes smoked after the quit date (rate ratio (RR) = 1.92, p = 0.07). At the within-person level, women’s higher than usual CHBs were unrelated to intention to quit, but were related to less smoking before (RR = 0.96, p = 0.03) and at the 10% level after the quit date (RR = 0.91, p = 0.09). A marginally positive association between daily CHBs and smoking at the within-person level emerged for men. The negative effect of daily CHBs at the between-person level on smoking seems to unfold after the quit attempt and for women only.
Enhancement of Contact Lens Disinfection by Combining Disinfectant with Visible Light Irradiation
Authors: Hoenes Katharina , Spellerberg Barbara , Hessling Martin
Published: September 2020

Multiple use contact lenses have to be disinfected overnight to reduce the risk of infections. However, several studies demonstrated that not only microorganisms are affected by the disinfectants, but also ocular epithelial cells, which come into contact via residuals at reinsertion of the lens. Visible light has been demonstrated to achieve an inactivation effect on several bacterial and fungal species. Combinations with other disinfection methods often showed better results compared to separately applied methods. We therefore investigated contact lens disinfection solutions combined with 405 nm irradiation, with the intention to reduce the disinfectant concentration of ReNu Multiplus, OptiFree Express or AOSept while maintaining adequate disinfection results due to combination benefits. Pseudomonads, staphylococci and E. coli were studied with disk diffusion assay, colony forming unit (cfu) determination and growth delay. A log reduction of 4.49 was achieved for P. fluorescens in 2 h for 40% ReNu Multiplus combined with an irradiation intensity of 20 mW/cm2 at 405 nm. For AOSept the combination effect was so strong that 5% of AOSept in combination with light exhibited the same result as 100% AOSept alone. Combination of disinfectants with visible violet light is therefore considered a promising approach, as a reduction of potentially toxic ingredients can be achieved.
Psychosocial Influence of Ehlers–Danlos Syndrome in Daily Life of Patients: A Qualitative Study
Authors: Palomo-Toucedo Inmaculada , Leon-Larios Fatima , Reina-Bueno María , Vázquez-Bautista María , Munuera-Martínez Pedro , Domínguez-Maldonado Gabriel
Published: September 2020

(1) Background: Ehlers–Danlos syndrome is a heterogeneous group of connective tissue disorders causing pain, fatigue, and disabilities; it has several implications for patients who suffer from this disease. The major clinical manifestations of EDS include joint hypermobility, skin hyperextensibility, and generalized connective tissue fragility. This research aims to explore their perceptions and experiences about the phycological and social spheres. (2) Methods: Semistructured interviews were carried out. Participants were encouraged to talk about issues related to their disease by asking open-ended questions in one to one interview. The interview guide included questions to identify the syndrome’s influence on the social and psychological life of patients All interviews were audio recorded, fully transcribed, and analyzed using the phenomenological theoretical framework. The method of analysis was the thematic interpreting of perspectives and approaches. (3) Results: 31 individuals were proposed to participate in this study. Five patients refused to participate, so a total of 26 interviews were performed. Six themes ((1) Pain and its consequences on a daily basis; (2) The need to name the problem: the diagnosis; (3) Restructuring leisure and social relationships; (4) Limitations due to economic conditions; (5) Psychological impact of the disease situation; (6) Professional limitations) and four subthemes ((1) The value of partner support; (2) The weather influence on social plans; (3) Physical exercise and illness; (4) Support groups) emerged from the data. (4) Conclusions: This study revealed the impact of the syndrome on the social and daily life of patients, and not only in a physical level, but also in a psychological and social approach. These findings allow healthcare providers to know more about this disease in order to support and give advice to patients about the changes they will have to make.
The Impact of Enforcement Capabilities on the Effectiveness of Public Assessment on Occupational Safety
Authors: Soriano-Serrano Manuel , Carrillo-Castrillo Jesús Antonio , Rubio-Romero Juan Carlos , García-Jiménez Manuel
Published: September 2020

(1) Objective: The objective of this study was to evaluate the effect of enforcement capabilities on the efficacy of two public interventions to improve occupational safety in olive mills. (2) Method: The difference in efficacy was evaluated by comparing the risks detected in two groups in an initial assessment (with visits in the 2006–2008 period) to the risks detected in a later assessment, either after an intervention by Authorized Technicians with enforcement capabilities or after an intervention by Technical Advisors without enforcement capabilities (2011–2013). The assessments identified risks in the companies, according to a specific risk map for olive oil mill enterprises. (3) Results: Statistically significant differences were observed in the comparison of the risk reductions of the two groups, with regard to the initial assessment. The greatest reductions in risk were found in the companies that received interventions by Authorized Technicians with enforcement capabilities, in the sections of individual protection equipment and the storage of dangerous products. (4) Conclusion: Interventions by Authorized Technicians with enforcement capabilities are more effective than interventions by Technical Advisors without enforcement capabilities.
Needs, Aggravation, and Degree of Burnout in Informal Caregivers of Patients with Chronic Cardiovascular Disease
Authors: Szlenk-Czyczerska Elżbieta , Guzek Marika , Bielska Dorota Emilia , Ławnik Anna , Polański Piotr , Kurpas Donata
Published: September 2020

This study aimed to answer three main questions with respect to home caregivers for people with cardiovascular disease: (1) Are the needs of home caregivers being met (and at what level)?; (2) what is the level of emotional exhaustion, depersonalization, and personal accomplishment of home caregivers?; (3) what sociodemographic variables of home caregivers are related to unmet needs and level of emotional exhaustion, depersonalization, and personal accomplishment? The study used the Camberwell Modified Needs Assessment questionnaire and the Maslach Burnout Inventory questionnaire. This study reports on 161 informal home caregivers of patients with cardiovascular disease. We found that younger caregivers were less likely to report unmet needs (p = 0.011), and showed lower rates of burnout on depersonalization and emotional exhaustion. In addition, caregivers who worked more often reported higher levels of met needs (p = 0.022), and showed lower rates of burnout on depersonalization (p = 0.005) and emotional exhaustion (p = 0.018). Subjects residing in urban areas were more likely to report unmet needs (p = 0.007), and showed higher rates of burnout on emotional exhaustion (p = 0.006). Older caregivers who are unemployed and reside in cities should be offered programs to determine their unmet needs and to receive support.