bluuebunny/crossref_metadata_2025 huggingface dataset:
Experiencias interculturales en la enseñanza de la Publicidad - aprendizaje colaborativo entre dos universidades de Perú y Colombia
Authors: Neira Daniel Fernando Sabogal , Piscoya Pedro Iván Córdova
Published: February 2024

Las prácticas y experiencias educativas internacionales y de trabajo colaborativo se fortalecieron en los últimos años debido a condiciones relacionadas con el confinamiento y la pos pandemia. Este artículo reporta estrategias de aprendizaje colaborativo intercultural para la enseñanza de la publicidad mediante una experiencia significativa en dos universidades de Perú y Colombia, que se desarrolla entre 2020 y 2023. Esta experiencia consiste en la asesoría integral en campañas publicitarias a 36 pequeñas y medianas empresas (pymes) de los dos países. La metodología es un estudio de caso mixto, descriptivo, participativo y longitudinal que busca aplicar un modelo pedagógico en el contexto publicitario. Los instrumentos empleados fueron las evaluaciones de los estudiantes a los profesores participantes, los conceptos de los empresarios para valorar la satisfacción de las empresas asesoradas y la sistematización de la experiencia.  Los resultados muestran que efectivamente existen factores de interculturalidad, transculturalidad e interculturalidad en las campañas resultantes, que responden a los intereses de los anunciantes colombianos y peruanos, teniendo en consideración el contexto de cada empresa analizada. Las conclusiones muestran que desarrollo del programa colaborativo permitió satisfacer las demandas de las pymes atendidas y contribuyó al aprendizaje intercultural de los estudiantes que formaron parte del programa.
A importância do acolhimento às crianças e adolescentes vítimas de incidentes traumáticos constatados durante o atendimento de ocorrências policiais militares
Authors: Beckert Rodrigo Giovani , Zancan Carolina Pauleto Ferraz
Published: February 2024

Este artigo suscita a discussão sobre a importância do adequado atendimento das vítimas diretas e indiretas de violência, com idade inferior a 18 anos.  Apresenta breve retrospecto histórico sobre a evolução do cuidado e proteção da infância e juventude no mundo, bem como estudos neurocientíficos que buscam comprovar os danos físicos e psicológicos de crianças e adolescentes submetidos a situações traumáticas, por curtos ou longos períodos. Por fim, sob a perspectiva operacional policial, discute ações práticas voltadas ao acolhimento de crianças e de adolescentes impactados ou atingidos pelos desdobramentos decorrentes do atendimento de ocorrências policiais militares de grave repercussão ou complexidade.
Novel Estrogen Receptor Dimerization BRET-Based Biosensors for Screening Estrogenic Endocrine-Disrupting Chemicals
Authors: Choi Gyuho , Kang Hyunkoo , Suh Jung-Soo , Lee Haksoo , Han Kiseok , Yoo Gaeun , Jo Hyejin , Shin Yeong Min , Kim Tae-Jin , Youn BuHyun
Published: February 2024

The increasing prevalence of endocrine-disrupting chemicals (EDCs) in our environment is a growing concern, with numerous studies highlighting their adverse effects on the human endocrine system. Among the EDCs, estrogenic endocrine-disrupting chemicals (eEDCs) are exogenous compounds that perturb estrogenic hormone function by interfering with estrogen receptor (ER) homo (α/α, β/β) or hetero (α/β) dimerization. To date, a comprehensive screening approach for eEDCs affecting all ER dimer forms in live cells is lacking. Here, we developed ER dimerization-detecting biosensors (ERDDBs), based on bioluminescence resonance energy transfer, for dimerization detection and rapid eEDC identification. To enhance the performance of these biosensors, we determined optimal donor and acceptor locations using computational analysis. Additionally, employing HaloTag as the acceptor and incorporating the P2A peptide as a linker yielded the highest sensitivity among the prototypes. We also established stable cell lines to screen potential ER dimerization inducers among estrogen analogs (EAs). The EAs were categorized through cross-comparison of ER dimer responses, utilizing EC values derived from a standard curve established with 17β-estradiol. We successfully classified 26 of 72 EAs, identifying which ER dimerization types they induce. Overall, our study underscores the effectiveness of the optimized ERDDB for detecting ER dimerization and its applicability in screening and identifying eEDCs.
Improved Neural Inductivity of Size-Controlled 3D Human Embryonic Stem Cells Using Magnetic Nanoparticles
Authors: Son Boram , Park Sora , Cho Sungwoo , Kim Jeong Ah , Baek Seung-Ho , Yoo Ki Hyun , Han Dongoh , Joo Jinmyoung , Park Hee Ho , Park Tai Hyun
Published: February 2024

Background:
To improve the efficiency of neural development from human embryonic stem cells, human embryoid body (hEB) generation is vital through 3-dimensional formation. However, conventional approaches still have limitations: long-term cultivation and laborious steps for lineage determination.
Methods:
In this study, we controlled the size of hEBs for ectodermal lineage specification using cell-penetrating magnetic nanoparticles (MNPs), which resulted in reduced time required for initial neural induction. The magnetized cells were applied to concentrated magnetic force for magnet-derived multicellular organization. The uniformly sized hEBs were differentiated in neural induction medium (NIM) and suspended condition. This neurally induced MNP-hEBs were compared with other groups.
Results:
As a result, the uniformly sized MNP-hEBs in NIM showed significantly improved neural inductivity through morphological analysis and expression of neural markers. Signaling pathways of the accelerated neural induction were detected via expression of representative proteins; Wnt signaling, dopaminergic neuronal pathway, intercellular communications, and mechanotransduction. Consequently, we could shorten the time necessary for early neurogenesis, thereby enhancing the neural induction efficiency.
Conclusion:
Overall, this study suggests not only the importance of size regulation of hEBs at initial differentiation stage but also the efficacy of MNP-based neural induction method and stimulations for enhanced neural tissue regeneration.
Competitive Roles of Conductivity and Lithiophility in Composite Lithium Metal Anode
Authors: Tang Wenbo , Shen Nailu , Xiong Xiaosong , Liu He , Sun Xin , Guo Jiaxin , Jiang Feng , Wang Tao , Ma Yuan , Zhong Yiren , He Jiarui , Zhu Zhi , Kong Long , Kalimuldina Gulnur , Cheng XinBing , Wu Yuping
Published: February 2024

For the three-dimensional conductive host, the uneven lithium deposition and the dependence on the pore structure and lithiophility are a great challenge for lithium metal anodes. Herein, we employed facial chemical etching techniques on brass foil to fabricate three-dimensional copper hosts with diverse pore structures and lithiophilities, thus intending to understand the lithium depositing mechanisms in porous hosts. The copper host with a more pronounced pore structure exhibits the lower polarization voltage induced by its large specific surface area, which reduces the local current density and provides a great deal of pathway for lithium ion diffusion. Meanwhile, it exhibits high nucleation overpotential and a short lifespan due to a reduced number of favorable lithium nucleation sites caused by the reduced lithiophilic zinc sites and a marked increase in the routes between nucleation sites. Therefore, the appropriate pore structure needs a consideration of efficient balance between the nucleation overpotential, the polarization voltage, and Coulombic efficiency. This insight underscores the pivotal role of well-suited pore structures in three-dimensional hosts, providing profound guidance for the efficient design of advanced host for lithium metal anode.
Identification and Analysis of Sex-Biased Copy Number Alterations
Authors: Zhang Chenhao , Yang Yang , Cui Qinghua , Zhao Dongyu , Cui Chunmei
Published: February 2024

Background
: Sex difference has long been recognized at cancer incidence, outcomes, and responses to therapy. Analyzing the somatic mutation profiles of large-scale cancer samples between the sexes have revealed several potential drivers of cancer with sex difference. However, it is still a demand for in-depth scrutinizing the sex-biased characteristics of genome instability to link the clinical differences for individual cancer type.
Methods
: Here, we utilized a published framework devised to specifically compare the copy number profiles between 2 groups to identify the sex-biased copy number alterations (CNAs) across 16 cancer types from the The Cancer Genome Atlas Program database, and dissected the impact of those CNAs.
Results
: Totally, 81 male-biased CNA regions and 23 female-biased CNA regions in 16 cancer types were found. Functional annotation analysis showed that several critical biological functions associated with sex-biased CNAs are shared in multiple cancer types, including immune-related pathways and regulation of cellular signaling. Most sex-biased CNAs have a substantial effect on transcriptional consequence, where the average of over 68% of genes have a linear relationship with CNAs across cancer types, and 14% of those genes are affected by the combination of the sex and copy number. Furthermore, 29 sex-biased CNA regions show latent capacity to be sex-specific prognostic biomarker such as CNA on 11q13.4 for head and neck cancer and lung cancer.
Conclusions
: This analysis offers new insights into the role of sex in cancer etiology and prognosis through a detailed characterization of sex differences in genome instability of diverse cancers.
De Novo Design of Spiro-Type Hole-Transporting Material: Anisotropic Regulation Toward Efficient and Stable Perovskite Solar Cells
Authors: Wang Xuran , Wang Mingliang , Zhang Zilong , Wei Dong , Cai Shidong , Li Yuheng , Zhang Rui , Zhang Liangliang , Zhang Ruidan , Zhu Chenhui , Huang Xiaozhen , Gao Feng , Gao Peng , Wang Yang , Huang Wei
Published: February 2024

2,2′,7,7′-Tetrakis(
N
,
N
-di-p-methoxyphenyl)-amine-9,9′-spirobifluorene (Spiro-OMeTAD) represents the state-of-the-art hole-transporting material (HTM) in n-i-p perovskite solar cells (PSCs). However, its susceptibility to stability issues has been a long-standing concern. In this study, we embark on a comprehensive exploration of the untapped potential within the family of spiro-type HTMs using an innovative anisotropic regulation strategy. Diverging from conventional approaches that can only modify spirobifluorene with single functional group, this approach allows us to independently tailor the two orthogonal components of the spiro-skeleton at the molecular level. The newly designed HTM, SF-MPA-MCz, features enhanced thermal stability, precise energy level alignment, superior film morphology, and optimized interfacial properties when compared to Spiro-OMeTAD, which contribute to a remarkable power conversion efficiency (PCE) of 24.53% for PSCs employing SF-MPA-MCz with substantially improved thermal stability and operational stability. Note that the optimal concentration for SF-MPA-MCz solution is only 30 mg/ml, significantly lower than Spiro-OMeTAD (>70 mg/ml), which could remarkably reduce the cost especially for large-area processing in future commercialization. This work presents a promising avenue for the versatile design of multifunctional HTMs, offering a blueprint for achieving efficient and stable PSCs.
Silencing circATXN1 in Aging Nucleus Pulposus Cell Alleviates Intervertebral Disc Degeneration via Correcting Progerin Mislocalization
Authors: Yu Chao , Zhao Jing , Cheng Feng , Chen Jiangjie , Chen Jinyang , Xu Haibin , Shi Kesi , Xia Kaishun , Ding Siwen , Wang Kanbin , Wang Ronghao , Chen Yazhou , Li Yi , Li Hao , Chen Qixin , Yu Xiaohua , Shao Fangwei , Liang Chengzhen , Li Fangcai
Published: February 2024

Circular RNAs (circRNAs) play a critical regulatory role in degenerative diseases; however, their functions and therapeutic applications in intervertebral disc degeneration (IVDD) have not been explored. Here, we identified that a novel circATXN1 highly accumulates in aging nucleus pulposus cells (NPCs) accountable for IVDD. CircATXN1 accelerates cellular senescence, disrupts extracellular matrix organization, and inhibits mitochondrial respiration. Mechanistically, circATXN1, regulated by heterogeneous nuclear ribonucleoprotein A2B1-mediated splicing circularization, promotes progerin translocation from the cell nucleus to the cytoplasm and inhibits the expression of insulin-like growth factor 1 receptor (IGF-1R). To demonstrate the therapeutic potential of circATXN1, siRNA targeting the backsplice junction of circATNX1 was screened and delivered by tetrahedral framework nucleic acids (tFNAs) due to their unique compositional and tetrahedral structural features. Our siRNA delivery system demonstrates superior abilities to transfect aging cells, clear intracellular ROS, and enhanced biological safety. Using siRNA–tFNAs to silence circATXN1, aging NPCs exhibit reduced mislocalization of progerin in the cytoplasm and up-regulation of IGF-1R, thereby demonstrating a rejuvenated cellular phenotype and improved mitochondrial function. In vivo, administering an aging cell-adapted siRNA nucleic acid framework delivery system to progerin pathologically expressed premature aging mice (zmpste24
−/−
) can ameliorate the cellular matrix in the nucleus pulposus tissue, effectively delaying IVDD. This study not only identified circATXN1 functioning as a cell senescence promoter in IVDD for the first time, but also successfully demonstrated its therapeutic potential via a tFNA-based siRNA delivery strategy.
Inclusive Virtual Reality Learning: Review and 'Best-Fit' Framework for Universal Learning
Authors: Wehrmann Frank , Zender Raphael
Published: February 2024

The rise of Virtual Reality (VR) in educational contexts has highlighted the need to design Virtual Reality Learning Applications (VRLAs) that prioritize inclusivity, accommodating a spectrum of learner needs. Despite the surging interest, there is a noticeable gap in research that delves into the specifics of creating VRLAs that are rooted in inclusive educational theory. This research sought to extract insights and recommendations for the development of VRLAs tailored for diverse student populations. The intention was to scrutinize research focused on the inclusive design elements of VRLAs, leading to the establishment of preliminary Inclusion Guidelines for VR Learning (IGVRL). Adopting the "best-fit" framework synthesis technique, the research anchored its findings in the Universal Design for Learning (UDL) framework. UDL was developed to mold learning experiences to meet the requirements of heterogenous learners. Using UDL as a coding framework, a comprehensive literature review was undertaken, adhering to the SPIDER search strategy. The review of literature revealed distinct design recommendations that facilitate inclusive learning within VRLAs. Information was systematically categorized based on UDL's nine classifications and subsequently distilled into the preliminary IGVRL. It's pertinent to note that these guidelines, while offering a foundational perspective, necessitate further in-depth evaluations for validation. The analytical process brought to the fore several themes that UDL did not adequately encompass, such as the nuances of embodied learning, the focus on VR contents and their immersive properties, and the pivotal role of collaboration and cooperation in VRLAs. These insights underscore the further need for research in these areas. Although some facets of VR accessibility were discussed, a deeper exploration into this domain was identified as crucial, reiterating the importance of accessibility in underpinning inclusive education. The research underscores the potential of VRLAs in promoting inclusivity within educational settings and introduces the preliminary IGVRL for VRLA design, specifically targeting K-12 contexts. This paper emphasizes the continuum of research required to refine and validate these guidelines, ensuring their applicability and efficacy in diverse educational scenarios.
Low-Threshold Digital Educational Escape Rooms Based on 360VR and Web-Based Forms
Authors: Wolf Mario , Montag Michael , Söbke Heinrich , Wehking Florian , Springer Christian
Published: February 2024

Escape rooms are an established game genre that has become popular in educational contexts in recent years. Digital escape rooms are variations, which use digital environments and may be played by participants not present on site. Compared to physical escape rooms, digital escape rooms are characterised by lower implementation and application efforts and at the same time by reduced intensity of the experiences. There is little evidence to date as to whether these low-threshold escape rooms are nevertheless sufficiently effective for learning. In this evaluation study, a learning activity based on a digital educational escape room (DEER) that uses the 360°-based spatial visualization (360VR) of a waterworks and a web-based form – contributing guidance and the escape room-specific challenges – is analysed. In the learning activity, students of environmental engineering study programs are asked to explore the 360VR-based waterworks guided by the instructions and challenges in the web-based form. Quantitative results of the study on learning outcomes and variables relevant to learning, such as emotion, motivation, and usability (N=73) are reported. The evaluation is supported by the qualitative results of guided interviews. Remarkably, some participants would have preferred to explore the 360VR environment without the guidance provided by the web-based form. Overall, the results show the learning effectiveness of the DEER, the efficacy of the web-based form as a guidance instrument, and values of learning-relevant variables that are conducive to learning. The DEER also achieved a high level of acceptance among students. Due to the low effort required for the creation of the DEER by lecturers and for application on the part of students, the presented combination of 360VR and web-based forms can be seen as a powerful low-threshold learning tool that enriches teaching.
Analysis of the Energy Efficiency of Poultry Houses in Türkiye
Authors: ASLAN Asiye
Published: February 2024

Türkiye is an important producer, consumer and exporter in the poultry farming industry across the world. The poultry farming is one of the fastest growing sectors in the field of food and agriculture and has become one of the strongest sectors over time. Especially with the development of industrial sectors, the effective usage and management of energy, which is the most important issue of almost every business, has recently become an important structure in the building sector in Türkiye. This study examined optimum insulation layer thickness, energy savings, and emissions of CO2 for the exterior walls and roofs of poultry farming facilities. The study used the degree day method, which is widely used in standard insulation calculations, in accordance with broiler production. As the equilibrium temperature, the desired temperature values of broilers for each week in the 6-week period were taken as the basis (31, 29, 25, 23.50, 22.50, 20.50°C). Life cycle cost analysis (LCCA) was applied to identify the optimal values of insulation thickness in the facilities. Accordingly, the optimum insulation layer thickness, savings amount, and payback period for the walls and roofs ranged between 0.043-0.270 m and 0.022-0.094 m, 7.53-164.65 S/m2 and 12.85-319.62 S/m2, 1.19-2.19 years and 1.18-1.99 years, respectively. It has been calculated that a 70-80% reduction in CO2 emissions could be managed by applying the optimum insulation layer thickness.
6 Şubat 2023 Tarihli Kahramanmaraş Depremleri Sonrasında Betonarme Yapıların İncelenmesi: Malatya İli Saha Çalışması
Authors: EKİNCİ Enes
Published: February 2024

Bir deprem ülkesi olan Türkiye’de 6 Şubat 2023 tarihinde Doğu Anadolu Fay Hattı’nda meydana gelen iki büyük deprem sonrasında 50,000’i aşkın insanımız hayatını kaybetmiş ve insanlar birçok sosyo-ekonomik problemler ile karşı karşıya kalmıştır. Kahramanmaraş’a bağlı Pazarcık ve Elbistan’da Mw 7.7 ve Mw 7.6 büyüklüklerde meydana gelen iki büyük deprem ülkemiz yüzölçümünün yaklaşık %14’üne, nüfusunun ise yaklaşık %16,4’üne tekabül edecek şekilde 11 ilimizi doğrudan etkilemiştir. 2022 yılı verilerine göre, depremden etkilenen bu illerde konut sayısı yaklaşık 5,6 milyon civarında olup, yarım milyondan fazla binanın ise hasar gördüğü belirlenmiştir. Meydana gelen bu depremler bu denli yüksek bir etki alanına sahip olması nedeniyle asrın felaketi olarak nitelendirilmiştir. Bu çalışmada, depremlerin en çok etkilediği illerden birisi olan Malatya’da gerçekleştirilen saha araştırmasından elde edilen bulguların sunulması amaçlanmıştır. Yapılan incelemeler sonucunda; yıkılan, hasar alan veya hasar alması olası görülen yapılarda gözlenen en temel sorunlar; zemin taşıma gücü düşük olan bölgelerde gerçekleştirilen inşa faaliyetleri, işçilik hataları, hatalı yapı tasarımları, bina yaşı, bitişik nizam imar planı (özellikle kat seviyelerinin farklı olması) ve oldukça düşük beton kalitesi olarak sıralanabilir.
First Record and Geographic Expansion of the Sebastes schlegelii in the Sea of Marmara
Authors: Karadurmuş Uğur , Güner Abdurrahman , Aydın Mehmet
Published: February 2024

This study reports the first-recorded presence of the Korean rockfish (Sebastes schlegelii) in the Sea of Marmara, signifying a notable geographical expansion beyond its natural range. The sampled male specimen, with a total length of 27.5 cm and a weight of 459.20 g, aligns with known size patterns observed in the Black Sea, suggesting a consistent trend. The unexpected presence of the species in the Sea of Marmara raises intriguing questions about its potential spread in the broader Mediterranean Sea basin. The adaptability of the Sebastes schlegelii to diverse environmental conditions underscores its ecological resilience. The study emphasizes the need for careful monitoring and management due to potential threats posed by invasive species, especially considering the vulnerabilities of the Sea of Marmara to climate change
MDPA Salud: Modelo de negocio adaptado a una nueva herramienta para el diagnóstico de hipertensión arterial por entrecruzamiento de escenarios
Authors:   , Olano Lucas Matías
Published: February 2024

En el presente proyecto, se plasmará el desarrollo de modelo de negocio de una doble aplicación móvil (MDPA Profesionales y MDPA Pacientes) que permite diagnosticar fenotipos hipertensivos por medio de entrecruzamiento de escenarios (MDPA, MAPA 24 hs y presión tomada en consultorio, PAC) con su correspondiente ingreso de datos y un informe automatizado final de diagnóstico que el médico profesional deberá certificar previo a su emisión al paciente. Cabe destacar que la herramienta en cuestión presentada permite, no solo detectar en forma diagnóstica el fenotipo hipertensivo de un paciente, sino también detectar que un individuo diagnosticado hipertenso y con tratamiento farmacológico puede necesitar un ajuste en su correspondiente medicación por estar en condiciones no controladas por tratamiento sub-óptimo. En MDPA Salud, el usuario es el profesional y el cliente el paciente. El médico utiliza la aplicación para gestionar la información del paciente y este último es quien abona el estudio por medio de Mercado Pago al escanear el código QR que su profesional asociado le proporcione. El equipo desarrollador obtendrá un 35% del valor de la práctica (aquí su retribución) y el 65% restante será propiedad del médico en cuestión. No existe en el mercado una aplicación con estas características. Hay algunas que permiten registrar los valores de presión arterial pero ninguna tiene algoritmos diagnósticos de fenotipos hipertensivos como MDPA Salud.
TANTANGAN DAN PELUANG IMPLEMENTASI KEBIJAKAN ZERO WASTE DI KOTA BAUBAU
Authors: Achmad Farid Yusud Nur Achmad
Published: February 2024

This research aims to evaluate implementing the Zero Waste policy in Baubau City, focusing on identifying challenges and opportunities encountered in the implementation process. The research method used is qualitative, with data collection conducted through in-depth interviews and direct observation in the field. The results of the study indicate that despite efforts from the government to promote the concept of Zero Waste and improve waste management infrastructure, several challenges still hinder the implementation of the policy. The main challenges identified include the lack of public awareness about the importance of sustainable waste management, limitations in waste management infrastructure, and the lack of active participation from the community in Zero Waste programs. However, the research also reveals significant opportunities to enhance the implementation of Zero Waste policy through collaboration with the private sector and NGOs, as well as through participatory approaches and community empowerment. By strengthening collective commitment and active participation from all stakeholders, it is hoped that Baubau City can successfully achieve the Zero Waste goal and serve as an example of environmentally friendly and sustainable waste management.
Study on the relation between interface trap creation and MOSFET degradation under channel hot carrier stressing at cryogenic temperatures
Authors: Suzuki Tatsuya , Miyaki Yohei , Mitani Yuichiro
Published: February 2024

In general, the degradation mechanism of MOSFETs has been discussed relating to hydrogen. For instance, interface traps are created due to the Si–H bond breakage at the MOS interface by hot (energetic) carriers under electrical stressing (e.g. channel hot carrier (CHC) and F-N stressing). In addition, it is also reported that hydrogen also relates to bulk trap creation. However, these hydrogen-related degradation mechanisms have been discussed based on the results within the conventional measurement temperature region. Recently, the reliabilities of MOSFETs at cryogenic temperatures have attracted much attention assuming that the electron devices are applied to quantum computing and space exploration. However, degradation mechanisms at cryogenic temperatures have yet to be fully clarified. In this paper, the degradations of MOSFETs under a CHC stressing in the temperature range of 77 K ∼ 300 K are investigated. Especially, we focus on the degradation of MOSFETs due to interface trap creation. As a result, MOSFETs degrade more under cryogenic temperature compared to that near RT. This result implies the existence of an additional degradation mechanism at cryogenic temperatures.
PLURALISME AGAMA DALAM PEMIKIRAN PESANTREN DENGAN PENDEKATAN TEORI INTERAKSIONISME SIMBOLIK
Authors: Nurma Yuwita
Published: February 2024

Penelitian ini mendiskripsikan pluralisme agama perspektif Kiai Sholeh Bahruddin dengan model pendekatan teori interaksionisme simbolik. Metodologi yang digunakan adalah kualitatif. Metodologi ini dipilih bertujuan untuk menjelaskan fenomena dengan sedalam-dalamnya. Penelitian ini menggunakan jenis penelitian deskriptif. Metode yang digunakan dalam mengumpulkan data adalah wawancara mendalam, observasi, dan dokumentasi. Pengambilan sampel yang digunakan adalah Non Probability Sampling dengan teknik pengambilan sampel purposive sampling.Pluralisme agama dalam pemikiran pesantren dengan pendekatan teori interaksionisme simbolik menghasilkan: 1) Makna pluralisme agama perspektif Kiai Sholeh Bahruddin yakni Allah menjadikan ciptaannya berbeda-beda agama yaitu: Islam, Kristen, Katholik, Hindu, Budha, dan Konghuchu dengan tujuan agar bisa saling belajar berbagai macam cara seperti toleransi agama, hidup bermasyarakat, saling membantu, dan mengakui perbedaan itu sebagai karunia yang diberikanNya sebagai realita kehidupan; 2) Pancasila merupakan landasan utama yang digunakan oleh Kiai Sholeh Bahruddin dalam mengimplementasikan nilai pluralisme agama. Selain itu konsep pluralisme agama Kiai Sholeh Bahruddin dilatar belakangi dari pola kepemimpinan Nabi Muhammad yang berdasarkan piagam madinah; 3) Interaksi antarumat beragama di pondok pesantren Ngalah diimplementasikan dengan “kerja sama sosial keagamaan” dengan konsep dialog antarumat beragama dan “kerja sama dalam bidang agama” dengan konsep doa bersama, hubungan antarumat beragama, live in agama.
Computer-Aided Diagnosis System for Automated Detection of Mri Brain Tumors
Authors:   Department Electrical and Computer Engineering, King Abdulaziz University, Jeddah, Makkah, Saudi Arabia., Alqasemi Umar S. , Almutawa Sultan A. ,   Department Electrical and Computer Engineering, King Abdulaziz University, Jeddah, Makkah, Saudi Arabia., Obaid Shadi M. ,   Department Electrical and Computer Engineering, King Abdulaziz University, Jeddah, Makkah, Saudi Arabia.
Published: February 2024

Detection and classification of brain tumors in manual or traditional way is an area which could be improved by having such automated detection and clarification system for brain tumors. In this paper, enhanced Computer-Aided Diagnosis CAD software system is introduced for brain tumor detection and classification. Total of 229 brain MRI images was taken as dataset for the purpose of this research; those dataset images include 105 normal brain MRI images, and 124 abnormal brain MRI images. Proposed CAD system is specialized for Meningioma brain tumor detection and classification, and the technique could be generalized and implemented for Glioma, and Pituitary brain tumors as well, and the whole system was implemented using MATLAB software. We started by cropping the region of interest (ROI) of dataset images. Then, feature extraction was implemented using first order statistical features, as well as using of some wavelets filters in combination with the former. T-test is used to exclude features of no statistical significance (p-value < 0.05). After that, different types of classifiers were used to separate the normal set from the abnormal one. Note that, we used an iterative approach to by changing features with many runs until we got best performance, where, best accuracy results were gotten with SVM-Kernel Function (Linear), KNN-1, KNN-3, and KNN-5 classifiers. Note also that, we used convolutional neural networks (CNN) from Deep Learning toolbox of MATLAB as a control method to compare, where the images were fed directly to the CNN. The results were evaluated using performance assessment techniques which are Sensitivity, Specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV), Accuracy, Error Rate, and Area Under the Curve (AUC) of Reciever Operator Characteristic (ROC). With SVM classifier, the best gotten accuracy results were 91 % with CNN classifier, 82% with SVM classifier, and 77 % with KNN classifier. Furthermore, it was very beneficial to find such feature extraction techniques which gave acceptable accuracy results with three different classifiers; this was the case two times as mentioned the study. All proposed CAD system areas was developed and implemented using MATLAB software.
Strategic Implementation and Organizational Performance of Deposit Taking Savings and Credit Cooperative Societies in Nairobi City County, Kenya
Authors: Mwangi Roseanne , Murigi Elishiba
Published: February 2024

This study sought to establish the influence of strategic implementation on organizational performance of Deposit Taking SACCOs in Nairobi City County, Kenya. The specific objectives of the study were to determine the influence of strategic competence, strategic direction, organization structure and strategic communication on organizational performance of Deposit Taking SACCOs in Nairobi City County. The study was grounded on several theories including Resource Based View theory, Game theory, General systems theory, and Contingency Theory. The study employed a descriptive research design. The target population was the 42 Deposit Taking SACCOs in Nairobi City County. There were 272 management (top, and middle) staffs working in the head offices of the DT-SACCOs. This research used both convenient and stratified random sampling. From the population of 272, a sample of 30% was selected. This generated a sample of 81 respondents. This study mainly relied on primary data collected using a semi-structured questionnaire. The pilot study was conducted using eight (8) respondents drawn from SACCOs in Machakos County. Machakos County was selected due to its convenience and suitability to portray the characteristics of the target population. Internal consistency method was tested using Cronbach’s Alpha test while validity was ensured by seeking lecturer’s opinions on the face validity of the research instrument. The researcher administered the survey questionnaires to the staff in DT- SACCOs in Nairobi City County. The data gathered was entered, cleaned, and analyzed using SPSS (Version 25). Descriptive analysis included frequencies, percentages, means and standard deviations. Multiple linear regression model was used to measure the relationship between the study variables. Tables were used to summarize responses for further analysis and facilitate comparison. The study found that strategic competence affects the performance of DT- SACCOs to a moderate extent. Technical knowledge, roles and task involvement, technological knowledge and job training influences the performance of DT SACCOs to great extents. The study found that strategic direction influences the performance of DT- SACCOs to a great extent. Mission, vision, planning and execution and that goals and objectives play great roles on the performance of the DT-SACCOs. From the study, organizational structure influences the performance of DT-SACCOs to a great extent. Task allocation and coordination, chain of command, teamwork and strategic communication were found to affect the performance of DT SACCOs to great extents. The study found that strategic communication influences the performance of DT-SACCOs to a moderate extent. The study concludes that strategic competences, strategic direction, organizational structures and strategic communication have great influence on the performance of DT-SACCOs.
Retrieval of Surface Waves Spectrum from UAV Nadir Video
Authors: Solodoch Aviv
Published: February 2024

Sea surface wave spectrum measurements are necessary for a host of basic research questions as well as for engineering and societal needs. However, most measurement techniques require great investment in infrastructure and time-intensive deployment techniques.
We propose a new approach of wave measurement from standard video footage recorded by low-cost Unmanned Aerial Vehicles (UAV). We address UAV nadir imagery, which are particularly simple to obtain operationally. The method relies on the fact that optical contrast of surface gravity waves is proportional to their steepness. We present a robust methodology of regularized inversion of the optical imagery spectra, resulting in retrieval of the three-dimensional wavenumber-frequency sea surface height spectrum. The system was tested in several sea trials and in different bathymetric depths and sea state conditions. The resulting wave bulk parameters and spectral characteristics are in good agreement with collocated measurements from wave buoys and bottom-mounted acoustic sensors. Simple deployment, mobility, and flexibility in spatial coverage show a great potential of UAVs to significantly enhance the availability of wave measurements.
The Hepato and Reno Protective Role of Curcumin against the Alterations in Some Biochemical Parameter and Histological Damage Induced by Monosodium Glutamate in Male Albino Rats
Authors: Jasim Shaimaa Mohammed Ali , Abdul-Zahra Noor I.
Published: February 2024

The main objective of current research was to investigate toxicity effect of Monosodium glutamate and protective role of Curcumin on some blood biochemical parameters, body weight gain, relative organ weight and histopathological alterations in liver and kidney tissues in male albino rats. Twenty animals of male rats (Rattus norvegicus), their weight ranged from 111 to 165 gm. The animals were divided into four groups: Each animal group contained five rat, first group was control negative (-ve) administrated distilled water, the second group was control positive (+ve) administrated curcumin, third group was administrated by Monosodium glutamate (MSG) at dose 20 mg per one Kg and the forth group was administrated by Monosodium glutamate (MSG) at dose 20mg/Kg of body weight + curcumin at dose 100 mg per one Kg of body weight. All animal groups were administrated orally about 30 days. The study recorded significant p≥0.05 increment in liver and kidney function parameters included [Alanine transaminase (ALT), Aspartate aminotransferase (AST), Urea and creatinine] after oral administration of animals with MSG and MSG + Curcumin as a comparison with control groups. The study recorded significant decrement p≥0.05 in liver and kidney function parameters included ALT, AST, Urea and creatinine) in group was administrated MSG + Curcumin in comparison with group was administrated MSG only. Additionally, current study revealed histopathological changes in liver and kidney tissue in groups were administrated MSG and MSG+ curcumin compared with + curcumin compared with control groups. Furthermore, the study revealed that curcumin had protective effect and result in slight histopathological changes in liver and kidney tissue by reducing the damage and in group was treated by MSG+ curcumin for 30 days compared with MSG treated group.
Prescription Trends on the Preference of Hypoglycemic Agents for the Management of Diabetes Mellitus in India
Authors: S Manjula , M Krishna Kumar
Published: February 2024

The management of type 2 diabetes requires multifactorial approach in terms of diet, lifestyle modification and pharmacological treatment to prevent or delay complications and maintain the quality of life. Several studies have been conducted to enhance the treatment of type 2 diabetes. However, there was a lack of data regarding the prescription pattern of antidiabetics among clinicians. So, a cross-sectional, questionnaire based study was conducted to gather information about the prevalence, risk factors, and management of diabetes within a population. The data was collected from 551 doctors across all over India. About 44% doctors reported that 5-10 patients per week were newly diagnosed with type 2 diabetes. In this study, 66% of the doctors reported cardiovascular events as a major complication and 28% of the doctors reported renal complications in uncontrolled type 2 diabetes patients. 48% of the 551 clinicians used DPP4 inhibitors as an add on, followed by 30% who reported the use of SGLT2 inhibitors. Notably, 92% of the participants reported urinary tract infection as the most common undesirable effect in their patients, with the usage of dapagliflozin. Nearly 30% of the clinicians in our survey have prescribed SGLT2 inhibitors for patients who are at >50% risk of developing chronic kidney disease. The results from our study, stated that most of the clinicians use DPP4 inhibitors and SGLT2 inhibitors as an add on to metformin in patients with a failure to control the glycaemic index. Dapagliflozin is prescribed not only to control the glycaemic index but also to reduce the hospitalization due to heart failure and other cardiovascular and renal co-morbidities.
Surgical Site Infection in the General Surgery Department at the Fousseyni Daou Hospital in Kayes
Authors: Gaoussou Sogoba , Drissa Katilé , Goundo Soumbounou , Lassina Goïta , Brehima Diallo Mohamed , Sidy Sangaré , Issaga Traoré Lamine , Mamaye Kouyaté , Salifou Diakité Adama , Moulaye Magassa , Hamidou Traoré , Drissa Traoré , Moustapha Kané
Published: February 2024

Objectives: To determine frequency, analyze risk factors, identify responsible germs and antibiotic susceptibility, and assess the cost of infection. Patients and Method: We conducted a prospective study (August 1, 2022 to February 2023) for a period of 6 months. During our series, we received 250 patients who had been operated on and hospitalized in the general surgery department. The diagnosis of surgical site infection was based on criteria set forth by the Atlanta CDC. Data collection was carried out by interviewing, consulting records and anaesthesia sheets. Surgical wound monitoring was done up to the 30th postoperative day. A sample was taken for each infection. The word processor and tables were made on Microsoft Word 2019. Data were captured and analyzed on SPSS software (version 25). Results: We collected a total of 250 patients in our study. 31 developed an infection of the surgical site, a frequency of 12.4%. There were 31 patients, including 23 men and 8 women, with a mean age of 34 years, with a standard deviation of 20.75. The most common type of infection was superficial incision infection with 70.9% followed by deep incision infection with 29.1%. Risk factors for Surgical Site Infection Were: haemoglobin level; the nature of the surgery; ALTEMEIR contamination class 3 and 4; NNISS index 1 and 2; the type of intervention with probability tests P<0.05. The analysis of the 31 samples resulted in 31 positive cultures, i.e. a bacteriological yield of 100%. Echerichia coli was the most isolated germ with 25.8%, followed by Enterobacter cloacae 19.3% and Enterococcus 19.3%. The Treatment was: Carrying out local care based on antiseptics (dakin; Betadine; hydrogen peroxide) and general (adapt to susceptibility testing). The consequence of surgical site infection was the prolongation of the hospital stay by an average of 19 days for infected patients; with an estimated additional cost of 294712 and 0% mortality.
A Lei de ordenación e xestión integrada do litoral de Galicia no réxime constitucional de atribución de competencias entre Estado e comunidades autónomas
Authors: Vázquez Rodríguez Adrián Agustín
Published: February 2024

Este traballo analiza a repartición de competencias entre o Estado e as comunidades autónomas en materia de ordenación do litoral, tomando como referencia a recente Lei de ordenación e xestiónintegrada do litoral de Galicia. En primeiro termo, exponse como o litoral é concibido na doutrina constitucional e a noción de territorio e competencias “extraterritoriais” das comunidades autónomas. Aténdeseespecialmente á Sentenza do Tribunal Constitucional 149/1991, sobre a Lei de costas de 1988, e á evolución que esta doutrina sufriu, moi especialmente nas sentenzas 31/2010 e 18/2022. Finalmente, examínase a regulación da nova lei galega e as súas innovacións con respecto deste réxime de competencias.
Riba Perspektif Madzhab Syi’ah Ithna ‘Asy’ariah: Analisis Ayat Riba Dalam Tafsir Majma Al-Bayan Fi Tafsir Al-Quran Karya Al-Thabarisi
Authors: Hibatullah Alif
Published: February 2024

Riba merupakan tambahan dari pinjaman dan ini diharamkan dalam Islam. Dan telah dijelaskan dalam Al-Qur’an. Umat Islam sebagai agama yang merujuk Al-Qur’an sebagai pedoman hidup faktanya memiliki berbagai aliran yang memiliki perbedaan hukum dan ideologi. Tetapi dalam diskursus riba dua kelompok Islam yakni Syi’ah dan Sunni memiliki persamaan tentang haramnya riba. Maka dari itu penelitian ini dilakukan. Metode yang digunakan adalah kualitatif. Dari hasil penelitian menunjukkan al-Thabarsi sebagai salah satu tokoh Syi’ah Ithna ‘Asy’ari merumuskan hukum riba memiliki tiga kandungan Pertama, riba sudah ada sejak zaman Nabi Muhammad, dan hal ini menjadi alasan di balik penurunan ayat-ayat yang melarang praktik riba. Kedua, larangan terhadap riba didasarkan pada kepedulian terhadap orang-orang yang berada dalam kesulitan; dengan menghindari riba, orang yang mampu dapat membantu orang yang kurang mampu. Ketiga, hal ini juga menyangkut prinsip keadilan, karena memberlakukan tambahan atas pinjaman akan memberatkan pihak yang meminjam, dan hal ini tidak adil serta berpotensi menciptakan ketidaksetaraan sosial.
CUIDADOS DE ENFERMAGEM NO BANHO DE ASPERSÃO EM INSTITUIÇÃO DE LONGA PERMANÊNCIA: REVISÃO INTEGRATIVA
Authors: De morais Fabiana , Dos Reis Bellaguarda Maria Lígia , Honorio Locks Melissa , Souza Lima Daniella Karine , Chiodelli Nádia , Dutra Tholl Adriana
Published: February 2024

Objetivo: Identificar os cuidados de enfermagem necessários para o banho de aspersão seguro para idosos no quotidiano de uma instituição de longa permanência. Método: Revisão Integrativa da literatura, recorte entre 2001 e 2022. Os dados dos estudos incluídos resultaram em uma síntese descritiva, fundamentada na Teoria das Necessidades Humanas Básicas.  Resultados: Obteve-se 13 estudos sobre cuidados no banho com e sem auxílio, envolvendo o equilíbrio psicobiológico, psicossocial e psicoespiritual, remoção de barreiras ambientais, adaptação domiciliar, maneiras de abordagem, musicoterapia e cuidados com a integridade da pele, oportunizando segurança e qualidade nas ações prestadas. Conclusões: Os cuidados precisam estar integrados às necessidades humanas básicas, respeitando as peculiaridades do processo de envelhecimento e as fragilidades dos idosos mais vulneráveis. A qualificação dos profissionais de enfermagem/cuidadores formais visa a padronização da execução do procedimento e a redução de ocorrência de desvios de procedimento.
Exploration of Machine Learning Model for Diabetes Prediction
Authors: Loganathan E. , Bruno X. Arul , Bhat Ashiq Hussain , Dharun S.
Published: February 2024

Diabetes is a metabolic disorder characterized by a malfunction in insulin release, resulting in a rise in blood sugar levels in the body. Diabetes diagnosis must be made on time and precisely in order to be effective and enhance patient outcomes. The diabetes management presents a formidable challenge in modern healthcare, demanding a combination of timely interventions, precise data analysis, and personalized medical services. Furthermore, there exists a growing demand for advanced predictive models that not only provide accurate forecasts but also offer transparency and interpretability. The study objectives are to develop an innovative machine learning model for data-driven diabetes prediction and medical services. To identify the machine learning model that best suits the proposed system, a literature review related to different methods used in diagnosing diabetes is conducted. The merits and demerits of each existing system were identified to devise a proposed model that seamlessly integrates data from various sources, including blood glucose levels and patient health information. Based on the review, the study suggests an innovative machine learning model that utilizes the Explainable Decision Tree Model, leveraging cloud computing to analyse diabetes patient data and make predictions. The integration of cloud computing allows for seamless data integration from various sources. This research project represents a significant step forward in personalized diabetes care, enabling patients to proactively manage their condition while providing healthcare professionals with a powerful tool for delivering tailored medical services.