bluuebunny/crossref_metadata_2025 huggingface dataset:
Hubungan Kecerdasan Emosional Dengan Resiliensi Pada Wanita Pasca Bencana Banjir
Authors: Sari Uswatun Hasanah Kartika , Purnawan Iwan , Hidayat Arif Imam
Published: December 2022

A disaster can have a wide range of effects, both physically and mentally. When tragedy strikes, women are particularly vulnerable and their resilience decreases. Someone who is in good psychological health normally has good interpersonal interactions, which influences emotional intelligence. The aim of this study is to discover a connection between emotional intelligence and resilience in women experiencing a flood disaster. This study was a correlational research with cross sectional design. This study was conducted out in Sirau Kemranjen, Banyumas Regency. This study’s sampling method was simple random sampling, which yielded 87 respondents. This study utilized an emotional intelligence and resilience instrument adapted from previous studies. Somers’d test was used to interpret the data in this analysis.
GRAMMATICAL AND SYNTACTIC SPECIFICS OF TRANSLATION OF ENGLISH USER MANUALS FOR HOUSEHOLD APPLIANCES INTO UKRAINIAN
Authors: Gudmanian Artur , Matkovska Hanna , Chaikovska Khrystyna
Published: December 2022

The article focuses on the study of grammatical and syntactic peculiarities of translation of English user manuals for household appliances. The study of the instructional text through the prism of linguistics and translation studies is relevant research, since the instruction is directly related to the high-tech process that causes the emergence of new products. This scenario requires further study of the phenomenon. The purpose of the article is to analyze the use of transformations in translation of English user manuals for household appliances into Ukrainian at the grammatical and syntactic levels. The object of the research is the text units of English and Ukrainian user manuals. The study is based on the user manuals for household appliances of such companies as Beko, Indesit, and Philips. During the study, the characteristic grammatical and syntactic peculiarities of the user manuals for household appliances were analyzed. The result of the study is the identification of the most common means of translation of the above-mentioned features. When translating user manuals into Ukrainian, literal translation is mostly often used. Syntactic permutation and sentence fragmentation are most frequently used next. Less frequent way of translating is sentence integration. Moreover, it was found that among the grammatical transformations, the most common are addition, omission and change of a part of speech.
Keywords: grammatical features; syntactic features; translation transformations; translation methods; user manuals.
ON THE DESTRUCTION AND PREFRACTURING OF SOLID ROCKS UNDER BLASTING IN FORMATION CONDITIONS
Authors: Voitenko Yu , Vapnichna Viktoria , Voitenko O.
Published: December 2022

Purpose and task. Analysis and specification of mechanisms of softening and change of structure of monolithic and low-fractured rocks under blasting of single and dispersed charges, definition of the reasons and model of their evolution in a formation. To solve this goal, the followingscientific tasks were set in the work:1. Estimation of force factors of external action on rock.2. Thermodynamic analysis and detection of mechanisms of structural changes in rocks at a considerable distance from the well, which provide a change in its productivity.Research methods. To solve the set tasks, the following were performed: calculations of the attenuation of shock wave amplitudes generated during the explosion of spherical and elongated charges; analysis of the results of explosive treatments of oil and gas wells; energy analysis of processes and mechanisms of changes that occur around the well in the reservoir.The main results. Studies have shown that structural changes in rocks during low-energy explosions, as well as other low-energy methods of external action on the reservoir occur in the form of increased cracking of rocks at micro and macro levels due to cooperative effects of external action, internal reservoir energy and physico-chemical effects of reservoir fluids.The main results. The mechanisms of decompaction of the rocks in rock formation conditions in the presence of rock and reservoir pressure at low-energy external actions are considered. Experiments on the operation of oil, oil and gas and gas wells show that the transition of the system "well - formation" from one thermodynamic state to another occurs in a time that depends on the internal energy of the formation. The transition is the result of the cooperative effects of the combined action of external influences, the internal energy of the formation and rock pressure. For gas wells this time does not exceed a few hours or days, for oil and oil and gas with depths of 3000… 4000 m the typical time of the well to reach maximum productivity is ≈ (30 - 90) days.Conclusions and practical significance. The analysis of the results of industrial tests of explosive intensification technology and calculations of attenuation of compression wave amplitudes show that under rock pressure conditions structural changes in rock after explosions of several charges occur at distances up to ≈ (80… 100) R0. Under reservoir conditions, the main reasons for the appearance of such long zones of increased permeability around the well are the cooperativeeffects of the combined action of blast waves, reservoir gases (methane, carbon dioxide, helium and possibly hydrogen), as well as changes in rock pressure in the process of its development. Of practical importance is to understand the sequence of technological operations in the work tointensify the inflow of oil and gas.
RESEARCH OF METRO TUNNEL SEDIMENTS UNDER THE CONDITIONS OF A WATER-SATURATED FLOOD MASSIVE
Authors: Musykhin Mariana
Published: December 2022

Purpose: analysis and selection of an appropriate way to improve the strength characteristics of soils by strengthening in the zones of weakening and reducing deformations of the tunnel structures, substantiating the methods of strengthening the base of the subway tunnel structure and the soil massif during deposition in the conditions of the underground space. On the basis of the analysis, propose an expedient method and schematic fixing of a water-saturated non-washable soil massif with stabilization of sediments and propose a method for reducing deformations during vibration subsidence.

Methodology: by using the survey and analysis of methods of strengthening the soil massif, geophysical methods of strengthening the foundations of the sandy water-saturated massif, a comprehensive approach is recommended for the implementation of increasing the level of strength of the subway tunnel.

Originality: on the basis of the performed analytical studies, the parameters for strengthening the soil of the water-saturated alluvial massif were determined and the combined method of strengthening the soil massif and the method of reducing the vibration subsidence caused by the speed of the trains in relation to the force of gravity during the oscillation of the structure of the base of the subway tunnel in the water-saturated alluvial massif were proposed. optimization of works, reduction of work terms and the possibility of applying a combined scheme of filling wells with solution and using them in conditions of dense urban development.

Findings and practical implications:  the combined scheme of strengthening the soil massif with the help of gas silicification and the installation of soil-polymer piles will allow to evenly reduce the sedimentation of the soil and the structure without harming the surrounding underground space and dense urban development, in particular, it will increase the strength characteristics and the service life of the distillation tunnel.

Keywords: physical and mechanical properties; water-saturated alluvial massif; subway tunnels; shallow laying; geophysical methods; tunnel deposition; tunnel fastening, gas silicification; low viscosity polyurethane.
Sharding-Based Proof-of-Stake Blockchain Protocols: Key Components & Probabilistic Security Analysis
Authors: Hafid Abdelatif , Hafid Abdelhakim Senhaji , Makrakis Dimitrios
Published: December 2022

Blockchain technology has been gaining great interest from a variety of sectors including healthcare, supply chain, and cryptocurrencies. However, Blockchain suffers from its limited ability to scale (i.e. low throughput and high latency). Several solutions have been proposed to tackle this. In particular, sharding proved that it is one of the most promising solutions to Blockchain’s scalability issue. Sharding can be divided into two major categories: (1) Sharding-based Proof-of-Work (PoW) Blockchain protocols, and (2) Sharding-based Proof-of-Stake (PoS) Blockchain protocols. The two categories achieve good performances (i.e. good throughput with a reasonable latency), but raise security issues. This article focuses on the second category. In this paper, we start by introducing the key components of sharding-based PoS Blockchain protocols. Then, we briefly introduce two consensus mechanisms, namely PoS and practical Byzantine Fault Tolerance (pBFT), and discuss their use and limitations in the context of sharding-based Blockchain protocols. Next, we provide a probabilistic model to analyze the security of these protocols. More specifically, we compute the probability of committing a faulty block and measure the security by computing the number of years to fail. Finally, we evaluate the effectiveness of the proposed model via numerical analysis.
Women’s Participation in Leadership Roles in a Single Canadian Paramedic Service
Authors: Mausz Justin , Salvis Sarah , Arseneau-Bruneau Dominique , Donnelly Elizabeth
Published: December 2022

Introduction Like other public safety professions, paramedicine has historically been a male-dominated occupation, both in the demography of its workforce and in its organizational culture. Although women are increasingly choosing paramedicine as a career, participation in leadership roles remains limited. Drawing on data from a recent comprehensive mental health survey, we describe the proportion of women in leadership in a single, large, urban paramedic service in Ontario, Canada. Methods We distributed an in-person, paper-based survey during the fall 2019 - winter 2020 Continuing Medical Education (CME) sessions. Participating paramedics completed a demographic questionnaire alongside a battery of mental health screening tools. We assessed the demography of the workforce and explored differences in employment classification, provider level (e.g., primary vs. advanced care), and participation in formal leadership roles along self-reported gender lines. Results Out of 607 paramedics attending CME, we received 600 completed surveys, with 11 excluded for missing data, leaving 589 for analysis and a 97% response rate. Women comprised 40% of the active-duty paramedic workforce, with an average of 8 years of experience. Compared to men, women were more than twice as likely to have a university degree (Odds Ratio [OR] 2.02), but almost half as likely to practice at the Advanced Care Paramedic level (OR 0.61), and somewhat less likely to be employed full-time (OR 0.77). Women were nearly 70% less likely to hold a leadership role in the service compared to men (OR 0.36), occupying just 20% of leadership positions. Conclusion Although paramedicine is witnessing an encouraging shift in the demography of its workforce with greater participation from women, there is still work to be done, particularly in leadership. Future research should focus on identifying and ameliorating barriers to career advancement among women and other historically underrepresented people.
Everything you Always Wanted to Know about the Biothermodynamic Background of Herpes Simplex Virus Type 1 – Host Interaction
Authors: Popovic Marko
Published: December 2022

Herpes simplex virus type 1 (HSV-1) is among the most widely spread viruses on the planet. However, the rate of binding to the receptor is not among the greatest ones. Gibbs energy of binding, which represents the driving force for antigen-receptor binding, of HSV-1 is less negative than can be expected. Furthermore, the Gibbs energy of biosynthesis of HSV-1 is among the most negative in nature. This implies high rate of multiplication of HSV-1. Obviously, HSV-1 uses specific strategy in virus-host interaction. While most other viruses increase infectivity through a high rate of antigen-receptor binding and cell entry/ highly negative Gibbs energy of binding, HSV-1 uses another strategy. It is related to a relatively slow reaction of antigen-receptor binding, which is followed by a higher rate of multiplication, which is a consequence of a highly negative Gibbs energy of biosynthesis. We can conclude empirically that both strategies are successful.
Diester Chlorogenoborate Complex: A New Naturally Occurring Boron-Containing Compound
Authors: Biţă Andrei , Scorei Ion Romulus , Rangavajla Nagendra , Bejenaru Ludovic Everard , Rău Gabriela , Bejenaru Cornelia , Ciocîlteu Maria Viorica , Dincă Laura , Neamţu Johny , Bunaciu Andrei , Mogoşanu George Dan
Published: December 2022

The natural compounds of boron have many applications, including as dietary supplement. Communication is based on the discovery that diester chlorogenoborate complex can be detected and quantified from green coffee bean. The study reports that such diester molecule can also be synthesized in stable form by direct reaction of boric acid and chlorogenic acid, in a mixture of acetonitrile–water (1:1, v/v), left to evaporate over a period of 48 hours, at room temperature, resulting a spirocyclic form (diester complex). The diester complex, with its molecular structure and digestibility attributes has potential application as prebiotic in gut health, oral health and as micronutrient essential for microbiota to human and animals.
Offshore Wind Farm Layout Optimization Considering the Power Collection System Cost
Authors: Obukhov S. G. , Davydov D. Y.
Published: December 2022

The paper proposes a method for optimizing the layout of offshore wind farms to increase their efficiency by reducing the effect of aerodynamic shading, minimizing electrical losses in cable lines of the system for receiving and transmitting electrical energy generated by wind turbines to the electrical grid of the power system. The task is reduced to determining several parameters that define the geometric dimensions and shape of the layout grid with pre-installed tur-bine locations. This approach, in contrast to the coordinate-wise search method, makes it possible to build symmetrical grid layouts of wind power plants, which in practice are more convenient in terms of maintenance and operation. Together with the optimization of the layout, the search for the optimal location of the offshore transformer substation and the synthesis of the scheme of cable joints between wind power plants has been carried out. To solve this problem, a heuristic algorithm was used to search for a minimum spanning tree with a restriction on the conductivity of connections, which made it possible to build realistic schemes and more adequately assess their technical and economic characteristics. As the results of testing the proposed methodology on the example of optimizing the layout of the Horns Rev 1 wind farm have shown, the use of this approach has reduced the cost of the electrical system by 10–12 %. This is 7–11 % higher than the result obtained by using the MST algorithm, which performs the construction of a circuit of cable joints of a simplified topology. The change in the size and shape of the boundaries of the wind farm site resulted in an increase in the estimated electricity generation by 2.3 % and a decrease in its cost by 4 %. When optimizing the layout of wind turbines within the fixed boundaries of the site, these indicators are improved by only 1 and 2 % as compared to the original scheme.
High-Density Solid-Free Flexible Microgel Fluid Loss Pill in High-Temperature and High-Pressure Reservoirs: Curing Mechanism and Working Performance
Authors: Jia Hu , Niu Chengcheng , Liang Wenlong , He Wei , Sun Jinsheng
Published: December 2022

The exploration of a multipressure well is often faced with the problem of blowout and loss of circulation coexisting. Using a high-density temporary plugging agent to plug the lower layer is an effective method to ensure the normal circulation of the upper kill fluid and realize the safe and efficient development of the reservoir. In a previous study, we reported a solid-free flexible colloidal completion fluid (SFCCF; Jia et al. 2022b). In this paper, an ultrahigh-temperature (180°C)-resistant, curable solid-free flexible microgel pill (SFMP) with variable density was prepared based on SFCCF. SFMP is mainly composed of flexible microgel absorbent copolymer material (abbreviated as KA01), and the water absorption law follows Flory’s elastic gel theory. SFMP breaks through the upper density limit of traditional solid-free brine-weighted polymer gels, and its curing density is up to 1.8 g/cm3. The strength of SFMP was increased by crosslinking the stabilizer with KA01 through an acylation reaction. In addition, the hydrogen bonding between stabilizer and phosphate and the phosphorylation between phosphate and KA01 jointly promoted the curing of SFMP. The curing of SFMP is the manifestation of a multistage reaction, and the internal reaction rate increased with the increase in heating rate. SFMP has good performance of dynamic temporary plugging and pressure bearing and can be completely degraded by the chemical breaker. The formation pressure coefficients of the multipressure well in the East China Sea range from 1.20 to 1.42. The SFMP with 1.5 g/cm3 was used to plug the lower perforation layer of the Well AX, which achieved a reservoir protection effect. After the flowback of SFMP, the Well AX met production allocation requirements. The developed SMFP provides a new way for downhole operation in high-temperature, high-pressure (HTHP) multipressure wells.
Towards a Just Energy Transition: Implications for communities in lower- and middle-income countries
Authors: Dalabajan Dante , Mayne Ruth , Bobson Blandina , Qazzaz Hadeel , Ushie Henry , Ocharan Jacobo , Farr Jason , Romero Jorge , Priego Karla , Gomez Correa Laura Victoria , Gomez Ortiz Leandro , Socci Ludovica , Buenaventura Goldman Marianne , Rosario Felizco Maria , Dabi Nafkote , Chauke Nkateko , Haq Oskar , Martinez Arellano Pilar , Mojica Enciso Sandra Patricia
Published: December 2022

More frequent or intense floods, heatwaves, wildfires, droughts and typhoons devastate people’s homes, livelihoods and the natural world. A clean energy transition is urgently needed to reduce carbon emissions and prevent the impacts worsening. Wealthy countries have the prime historic responsibility for the climate crisis and therefore for its mitigation. But as the clean energy transition gathers speed, it inevitably also impacts lower-income, lower-emitting countries and communities. This research report, written by 20 co-authors from Africa, Asia, Latin America, the Middle East, the US and Europe, investigates the implications of the energy transition for them, and asks how the world can achieve a truly just, as well as fast, transition. The findings highlight the stark choice facing humanity. If the transition is undertaken with justice and respect for communities’ rights at its heart, it offers an unprecedented opportunity to simultaneously mitigate the climate crisis and reduce poverty and inequality. Conversely, an unjust transition, which entrenches or exacerbates inequalities, risks generating public resistance and slowing the transition with devastating human consequences.
Generation of self-assembling heart organoids from human pluripotent stem cells
Authors: Lewis-Israeli Yonatan R. , Volmert Brett D. , Gabalski Mitchell A. , Huang Amanda R. , Aguirre Aitor
Published: December 2022

Studying the development and disease etiology in the developing human heart is limited by the ability to recapitulate the complexity of the heart in vitro. This protocol introduces a method to generate complex individually contained heart organoids derived from human pluripotent stem cells (hPSCs). Embryoid bodies (EBs) are formed in a 96 well plate generating 1 EB per well, allowing for 96 individualized experiments with each plate. EBs are differentiated into human heart organoids in a 3-step Wnt pathway modulation strategy including an activation, inhibition and a second activation step corresponding to mesoderm, cardiac mesoderm and proepicardial organ inductions, respectively. The resulting human heart organoids demonstrated cellular, molecular, structural, and transcriptomic features that closely resemble the developing fetal heart.
Rapid multiplexed qPCR analysis of cerebrospinal fluid and blood for highly prevalent somatic alterations present in central nervous system tumors
Authors: Bradley Joseph , Gupta Mihir , Burns Evan , Maron Garrett , Georgantas Nicholas Zeke , Lennerz Jochen , Shankar Ganesh
Published: December 2022

This protocol describes a qPCR-based assay that is designed to detect twelve potential mutations from clinical specimens that are significant to CNS neoplasms. The assay is optimized for plasma and cerebrospinal fluid (CSF), where both cell-free DNA (cfDNA) and DNA derived from circulating tumor cells (CTCs) can be analyzed.
Protocol for targeted analysis of transposable element methylation levels and transcriptome in single cells using scTEM-seq
Authors: Hunt Kooper V , Burnard Sean M , Bond Danielle R , Lee Heather J
Published: December 2022

Many powerful techniques are available for the analysis of single cell DNA methylation, but all have associated technical challenges. Throughput and coverage are common challenges, and expense is a limitation of practically all single cell DNA methylation and related multiomic methods. Single cell transposable element methylation sequencing (scTEM-seq) provides a simplified protocol for analysis of global DNA methylation that alleviates the costs associated with single cell sequencing. Paired with fluorescence activated cell sorting (FACS) and parallel transcriptome analysis for each cell, scTEM-seq allows analysis of the effects of global DNA methylation changes in various cell populations of interest. In this method, targeted bisulfite sequencing of high copy number transposable elements (TEs) is utilised to provide an accurate estimate for genome-wide methylation with very low sequencing demands
Fuzzy Based Cluster Routing in Wireless Sensor Network
Authors: Naderloo AliReza , Aghda Seyed Ali Fatemi , Mirfakhraei Mahdi
Published: December 2022

Wireless sensor networks (WSNs) built for multiple purposes consist of a number of sensor nodes and base station (BS). In designing these networks, hierarchical cluster routing protocol is used as a common solution for the challenge of energy consumption and longer network lifetime. The strategy of proposed method (FBCR) is basead on zoning and a fuzzy-based cluster routing protocol. In this method, some of the nodes are selected as cluster heads (CHs) that are responsible for sending data to the BS. For fuzzy input in CH selection, the criteria were used, including “residual energy of the node”, “node distance to the center of each region”, and “node angle to the BS”. Fuzzy logic was used as an algorithm for modeling decision-making and human experiences, to maintain energy balance and better CH selection. In FBCR, with the aim of reducing network energy consumption, the responsibility of selecting CHs in each region, determining the region of nodes, calculating distance from each node to the center, and calculating angle of nodes were assigned to the BS. FBCR is improved in terms of network lifetime, stability Period, selection and number of CHs, and the mean residual energy compared to Farahzadi, LEACH and MSCR methods.
Unintended pregnancy and mental health among women in Uttar Pradesh and Bihar: Evidence from UDAYA survey
Authors: Sharma Himani , Maurya Chanda
Published: December 2022

Background
A pregnancy is the most crucial phase of a woman’s life, both physically and mentally. Studies reveals that women with an unintended pregnancy are at an increased risk of depression during pregnancy. As depression, anxiety, or stress during pregnancy can severely affect the health of women and children. This study attempts to scrutinize the association between intention of pregnancy and depressive symptoms among young adolescent girls.
Data and methods
We used data from Understanding the lives of adolescents and young adults (UDAYA, 2018). The adequate sample size was 5,165 currently married adolescent aged (15–23 years), who were either had a pregnancy with a successful outcome or presently pregnant. Descriptive statistics and bivariate analysis with percentages and chi-square test were used to find the preliminary results. For analyzing the association between unintended pregnancy and depression, the binary logistic regression analysis was conducted.
Results
Nearly 37% of the women’s had unintended pregnancy. The prevalence of depressive symptoms was higher (44%) among women who had unintended pregnancies. Women who have unintended pregnancy were 33 percent higher likely to suffer from depressive-symptoms than their counterparts [AOR: 1.33, CI: 1.18–1.50]. The odds of depression [UOR: 1.13, CI: 1.00-1.28] were more among women who ever had worse pregnancy outcome than their counterparts.
Conclusion
Women reporting that the pregnancy was unwanted were almost twice as likely to experience depressive symptoms compared women with a wanted pregnancy. It is thus, important to give attention to the reproductive health choice, unmet need for contraceptives and social support among women, especially from disadvantageous social groups.
A strategy to develop one step real-time RT-PCR for diagnosis of SARS-CoV-2 infection from clinical samples
Authors: Kumar Arbind , Kumar Arun , Padwad Yogendra , Sharma Shaifali , Kumar Sanjay
Published: December 2022

The aim of this study is to develop a one-step real-time PCR assay for SARS-CoV-2 detection. A lysis solution was prepared using Tween-20, Triton X-100, EDTA, and tris buffer (pH 7.4) and various parameters were optimised. Adding carrier molecules [Poly (A), glycogen, and linear polyacrylamide] to the lysis solution significantly improved RT-qPCR efficacy. Poly (A) was the most effective of all carriers. Diagnostic potential of this Poly (A) solution was demonstrated using 150 positives and 200 negative swabs, and the sensitivity of the RT-qPCR diagnostic test was estimated to be 98.6 (95%CI; 96.0, 101.17, p < 0.001) for group 1; Ct ≤ 25 and 87.2 (95%CI; 80.2, 94.0, p < 0.001) for group 2; Ct ≥ 25–30, with excellent accuracy (0.9 < AUC < 1.0), and 100% specificity.
High fibrinogen levels are associated with poor survival in patients with liposarcoma
Authors: Peschek Leonie S. , Hobusch Gerhard M. , Funovics Philipp T. , Willegger Madeleine , Schmid Maximilian P. , Amann Gabriele , Lamm Wolfgang , Brodowicz Thomas , Ay Cihan , Windhager Reinhard , Panotopoulos Joannis
Published: December 2022

Purpose
The aim of this study was to evaluate whether (preoperative) plasma levels of fibrinogen, an essential clotting and acute phase protein, are associated with the prognosis of patients with a liposarcoma, a subtype of sarcoma derived from adipose tissue.
Methods
We performed a retrospective cohort study of 158 patients with liposarcoma treated at the Department of Orthopaedics of the Medical University of Vienna in Austria from May 1994 to October 2021. Kaplan-Meier curves as well as uni- and multivariable Cox proportional hazard models were performed to evaluate the association between fibrinogen levels and overall survival.
Results
Elevated fibrinogen was associated with adverse overall survival in cause specific hazards analysis of mortality (hazard ratio [HR] per 10g/L increase: 1,04; 95% CI 1,02–1,06; p < 0,001). This association prevailed in multivariable analysis after adjustment for AJCC tumor stage (HR 1,03; 95% CI 1.01–1.05; p = 0.013).
Conclusions
Increasing levels of fibrinogen, a routinely available and inexpensive parameter, predicts the risk of mortality in patients with liposarcoma.
The effect of dry needling compared to lumbar spine mobilization on pain, functional disability, quadratus lumborum and lumbar multifidus function, lumbar range of motion and pain pressure threshold in patients with non-specific chronic low back pain: Study protocol for a randomized controlled trial
Authors: Mirzaie Hamide , Pourahmadi Mohammad Reza , Ayoubpour Mohamad reza , firouze bahare
Published: December 2022

Background: Low back pain (LBP) is a socioeconomic burden worldwide and a major contributor to health-care costs. Mobilization and dry needling (DN) are well-known treatments for LBP. Just one study has compared these two treatments with each other which has some limitations, therefore the purpose of this study is to compare them to each other.
Methods and study design: The study is a two-arm randomized, double-blind, double-dummy, controlled trial comparing DN to lumbar spine mobilization in individuals (n=56; 18–45 years of age) with chronic non-specific LBP (CNLBP). The experimental group will receive DN plus sham mobilization and the control group will receive Maitland’s anterior-posterior mobilization plus sham DN. Both groups will receive exercise and low-power laser. The primary outcomes are pain and functional disability, and the secondary outcomes are lumbar multifidus and quadratus lumborum function, lumbar range of motion, pain pressure threshold, DN side effects, and patient adherence to treatment. Primary and secondary outcomes will be assessed at baseline and 3 to 7 days after the final treatment session. Recruitment will begin immediately after acceptance of the protocol and it will take 5 to 6 months to complete the study.
Discussion: In this study, we intend to solve the methodological problems of the previous study in this field. The results of this study allow the therapist to choose an intervention that has more therapeutic effects in combination with routine physiotherapy in the treatment of patients with CNLBP.
Trial registration: 1) ClinicalTrials.gov registration number: NCT05214456. 2) IRCT.ir registration number: IRCT20210706051802N1.
Co2 emission analysis of metakaolin and alccofine replaced concrete in m40 grade concrete
Authors: chandar sekaran prakash , Raganathan Santhosh
Published: December 2022

Among the largest CO2 emission industries, the cement industry is ranked at 2nd place. Large volume of CO2 is emitted at the clinker production, which is a cement manufacturing intermediate product. Countries around the world were having difficulty reducing atmospheric emissions of greenhouse gases (GHG). Concrete is still being used more and more as the nation's infrastructure advances. The amount of CO2 emitted by concrete can be decreased by using less cement or substituting other materials for cement. In this study the CO2 emission analysis is made on M40 grade, which is metakaolin (MK) and alccofine (AL) replaced concrete and is compared with the conventional concrete. The optimum cement replacement of MK and AL is 10% in the production of M40 grade concrete. The LCA (life cycle analysis) is made for the concrete specimens and the results were interpreted to know which concrete sample emits less and more carbon dioxide. These results could also help in identify the major cause for the CO2 emission and it can be used for the further research purposes..
HotSPOT: a computational tool to design targeted sequencing panels to assess early photocarcinogenesis
Authors: Grant Sydney R , Rosario Spencer R , Patentreger Andrew D , Shary Nico , Fitzgerald Megan E , Singh Prashant K , Foster Barbara A , Huss Wendy J , Wei Lei , Paragh Gyorgy
Published: December 2022

Mutations found in skin are acquired in specific patterns, clustering around mutation-prone genomic locations. The most mutation-prone genomic areas, mutation hotspots, first induce the growth of small cell clones in healthy skin. Mutations accumulate over time, and driver mutation clones may give rise to skin cancer. Early mutation accumulation is a crucial first step in photocarcinogenesis. Therefore, a sufficient understanding of the process may help predict disease onset and identify avenues for skin cancer prevention. Early epidermal mutation profiles are typically established using high depth targeted next-generation sequencing. However, there is currently a lack of tools for designing custom panels to capture mutation-enriched genomic regions efficiently. To address this issue, we created a computational algorithm that implements a pseudo-exhaustive approach to identify the best targeted genomic areas. We benchmarked the current algorithm in three independent mutation datasets of human epidermal samples. Compared to the sequencing panel designs originally used in these publications, the mutation capture efficacy (# of mutations/base pairs sequenced) of our designed panel improved 9.6 to 12.1-fold. Our web application hotSPOT provides a publicly available resource for researchers to design custom panels, enabling efficient detection of somatic mutations in clinically normal tissues and other similar targeted sequencing studies.
Study on the feasibility of pharmacist intervention on management of antidepressant treatment in late life depression under MDT: a mixed methods study
Authors: Wu Ju , Li Jun , Qiu Linghe , Wu Jianhong
Published: December 2022

OBJECTIVE: To evaluate the effect of pharmacist intervention on antidepressant treatment in late life depression under multidisciplinary team (MDT).
Method: Patients with late life depression were selected from psychological department of The Afliated Wuxi Mental Health Center of Jiangnan University from Jan. 2021 to Mar. 2022, and randomly divided into observation group and control group, with 90 cases in each group. After 3 months of follow-up, the control group was given antidepressants and routine intervention, while the observation group was treated with pharmacist intervention under MDT and the same antidepressants. The Hamilton Depression scale (HAMD), medication appropriateness index (MAI), potential inappropriate medication (PIM), adherence, quality of life and satisfaction, the incidence of adverse drug events (ADEs), number of medication regimen optimization and clinician adoption rate were observed in two groups before and after intervention.
Results: At admission, there were no statistically difference in HAMD score, total MAI scores, PIM number, adherence and quality of life between two groups (P>0.05).
After intervention, HAMD scores of both groups were significantly reduced, while MMAS-8, GQOLI-74 and GWB scores were elevated. Moreover, the differences of scores before and after interventions, both the reduction in HAMD score and the increase in MMAS-8, GQOLI-74 and GWB scores, were more significant in the observation group than in the control group. Interestingly, the total MAI score and PIM number were increased in the control group after intervention, but decreased in the observation group. With the prolongation of the treatment, the number of patients with mild to moderate depression and general to high medication adherence in two groups was increased gradually, while patients with major depression and low medication adherence were decreased gradually. Meanwhile, the observation group also showed more significant difference than the control group. Low adherence patients increased substantially at 90 days treatment in control group. There was no significant difference in the incidence of ADEs between two groups (P>0.05). The quality of life in the observation group was significantly higher than control group (P<0.05). Pharmacists put forward 164 optimization suggestions of drug regimen for the observation group, among which 109 suggestions were adopted and implemented by clinicians, with an implementation rate of 66.46%. Clinicians have a high adoption rate of pharmaceutical recommendations based on therapeutic drug monitoring (TDM), individualized genetic testing and medication methods.
Conclusion: Pharmacist intervention can improve the management of antidepressant treatment in late life depression by using HAMD, MAI, PIM and MMAS-8 as main evaluation indicators under MDT.
Architectural design strategies for enhancement of thermal and energy performance of PCMs-embedded envelope system for an office building in a typical arid Saharan climate
Authors: Sarri Abdelkader , Al-Saadi Saleh Nasser , Arıcı Müslüm , Bechki Djamel , Bouguettaia Hamza
Published: December 2022

The literature showed many studies that evaluated a single or multiple Phase change materials (PCMs) layers in passive, active or in hybrid configurations for building applications. However, little attention has been given to evaluate the energy performance of buildings when PCMs are used together with other passive design strategies. In this work, the energy performance of an office building in a typical arid Saharan climate is simulated using EnergyPlus when phase change materials (PCMs)-embedded envelope is implemented. The office building was analyzed without/with PCMs using various thicknesses. Results indicated that the annual electrical energy for heating, ventilation and air conditioning (HVAC) can be reduced between 3.54% and 6.18%, depending on the PCM thickness. The performance of the office building including PCMs was then simulated using two practical architectural design strategies, namely windows to wall ratio (WWR) and rezoning of the interior spaces. Outcomes revealed that the annual energy consumption for HVAC can be reduced from 10% to 15.5% and from 6.1% and 8.54% when WWR is reduced by half to three-quarters and the perimeter zones are enlarged by one-third to two-thirds of the original space area, respectively. With combining both architectural design strategies with PCM, the annual electrical HVAC energy can be reduced between 12.08% and 15.69%, depending on the design configuration and PCM thickness. This design option provides additional benefits also since it reduces the vulnerability of increasing the lighting and fuel gas heating energy because more perimeter zones are exposed to daylighting and solar radiation, respectively.
Using Oncotype DX Breast Recurrence Score® Assay to Define the Role of Neoadjuvant Endocrine Therapy in Early-Stage Hormone Receptor-Positive Breast Cancer
Authors: Taylor Caitlin , Meisel Jane , Foreman Aimee , Russell Christy , Bandyopdhyay Dipankar , Deng Xiaoyan , Floyd Lisa , Zelnak Amelia , Bear Harry , O'Regan Ruth
Published: December 2022

Purpose
The role of neoadjuvant endocrine therapy in the treatment of patients with early stage, hormone receptor-positive (HR+) breast cancer is not well defined. During the early part of the COVID-19 pandemic, neoadjuvant endocrine therapy was used more commonly by physicians in an attempt to delay surgery and possible exposure to COVID-19 during hospitalization; this change raised important questions surrounding the use of neoadjuvant endocrine therapy.
Methods
We assessed the rate of clinical and pathologic complete response (cCR, pCR) among a pooled cohort of patients with early stage HR + breast cancer who had been randomized to neoadjuvant endocrine therapy or neoadjuvant chemotherapy in two earlier studies to understand better how outcomes varied by Oncotype DX Breast Recurrence Score® assay.
Results
We observed that patients with intermediate RS results had no statistically significant differences in pathologic outcomes at the time of surgery based on whether they received neoadjuvant endocrine therapy or neoadjuvant chemotherapy, suggesting that a subgroup of women with a RS 0–25 may omit chemotherapy without compromising outcomes.
Conclusion
These data suggest that Recurrence Score® (RS) results may serve as a useful tool in treatment decision-making in the neoadjuvant setting.
Abnormal Wall Shear Stress Area is Correlated to Coronary Artery Bypass Graft Remodeling One Year After Surgery
Authors: Tran-Nguyen Nhien , Yan Andrew T , Fremes Stephen , Triverio Piero , Jimenez-Juan Laura
Published: December 2022

Coronary artery bypass graft surgery is a common intervention for coronary artery disease; however, it suffers from graft failure, and the underlying mechanisms are not fully understood. To better understand the relation between graft hemodynamics and surgical outcomes, we performed computational fluid dynamics simulations with deformable vessel walls in 10 study participants (24 bypass grafts) based on CT and 4D flow MRI one month after surgery to quantify lumen diameter, wall shear stress (WSS), and related hemodynamic measures. A second CT acquisition was performed one year after surgery to quantify lumen remodeling. Compared to venous grafts, left internal mammary artery grafts experienced lower abnormal WSS (< 1 Pa) area one month after surgery (13.8% vs. 70.1%, p = 0.001) and less inward lumen remodeling one year after surgery (-2.4% vs. -16.1%, p = 0.027). Abnormal WSS area one month post surgery correlated with percent change in graft lumen diameter one year post surgery (p = 0.030). This study shows for the first time prospectively a correlation between abnormal WSS area one month post surgery and graft lumen remodeling one year post surgery, suggesting that shear-related mechanisms may play a role in post-operative graft remodeling and might help explain differences in failure rates between arterial and venous grafts.
Association between low alanine aminotransferase levels and sarcopenia in older adults: A cross-sectional study
Authors: Luo Li , Li Jiaying , Song Jiao , Li Ying
Published: December 2022

Background
This study aimed to determine whether serum alanine aminotransferase (ALT) is a convenient tool to screen sarcopenia and frailty in clinical practice.
Methods
This cross-sectional and observational study included a total of 1333 residents from three communities in Chengdu, China. A bioimpedance analysis device was used to measure the appendicular skeletal muscle mass (ASM). Handgrip strength was measured with a digital handheld dynamometer. Gait speed was measured with a 6-m gait test. The sarcopenia was defined according to the Asian Working Group on Sarcopenia (AWGS) 2019. Biochemical variables including ALT were tested in the same laboratory. Other characteristics, including smoking status, alcohol drinking status, education level, and chronic comorbidities, were obtained through a face-to-face interview. We used logistic regression to evaluate the association between ALT levels and sarcopenia.
Results
Compared with the non-sarcopenia group, the sarcopenia group had a significantly lower body mass index (BMI), serum albumin levels, hemoglobin levels, calf circumference (CC), and ALT levels. Both men and women with sarcopenia or low handgrip strength had lower ALT levels than those without sarcopenia or low handgrip strength. Compared with the highest ALT quartile, the odds ratios (OR) for individuals in the lowest ALT quartile were found to be increased (OR 1.68, 95% confidence interval 1.13–2.49, P = 0.010), adjusting for age, sex, BMI, hemoglobin levels, CC, and serum albumin levels.
Conclusions
Low ALT levels were associated with sarcopenia onset involving low skeletal muscle mass and handgrip strength in older adults. ALT measurement could be used as a simple and preliminary tool to screen for frailty and sarcopenia.
Factors Affecting Conservation of Grevy’s zebra/Equus grevyi/ in Alledeghi-Assebot Proposed National Park, south eastern Ethiopia
Authors: Abirham Tolera , Bekele Afework , Yihune Mesele
Published: December 2022

This research was carried out in Alledeghi Assebot Proposed National Park, which is located in Afar region in the southeast of Ethiopia. Data were collected from March 2021 to April, 2022 using household survey, key informant interviews, field observation, and walking along transect line. Data were analyzed with descriptive statistics and responses rate were compared using chi-square test. 90 % of the participants were men, and 68.7% were illiterate. The average age of the respondent was 30. Habitat degradation (94.7%), disintegrated development (92.4%) and poor law enforcement (90.7%) were the major top three conservation threat for Grevy zebra and their relative threat factor severity index are 0.38, 0.378, and 0.356, respectively. There is highly significant difference among literate and illiterate respondents (𝜒2 =51.84, df=1, p= 0.00 < 0.05). Furthermore, there is significant difference between gender of the respondents (𝜒2 =21.98, df=1, p= 0.001 < 0.05). Close monitoring of Grevy’s zebra population during prolonged droughts need to be carried out by scouts and additional water provision need to be made to ensure continued access to declining water sources and avoid impact of corridor closing due to settlement. The government and other stakeholders should give attention to address the prioritized threats.
High lncCASC expression predicts poor colorectal cancer prognosis, based on an systematic review and meta-analysis
Authors: Luo Pei , Du Jie , Han Huimeng , Pan Dingguo , Cai Xin , Dong Jian
Published: December 2022

Background
Recent years, Growing studies have shown that long non-coding RNA CASC (lncCASC) is significantly related to the prognosis of colorectal cancer. Limited by the small number of cases in a single study and the inconsistent results various related studies, an systematic evaluation and meta-analysis was performed to explore the correlation between lncCASC expression and prognosis of colorectal cancer.
Methods
A comprehensive search of 6 relevant databases including Pubmed, Embase, Web of Science, Cochrane library, CNKI and Wanfang database was conducted. The literature was screened according to the inclusion and exclusion criteria, and the quality of the literature was evaluated using NOS score. The pool HR with 95% confidence interval (CI) were used to evaluate the correlation between lncCASC expression and OS of patients. Pool OR 95% CI was used to evaluate the effect-value such as TNM stage, lymph node metastasis and DM ect. P-value and I2 (consistency index) test were used for heterogeneity analysis. Subgroup analysis and sensitivity analysis were used to explore the sources of heterogeneity in the included literature.
Results
According to the inclusion and exclusion criteria, 8 studies with 483 patients were finally retrieved. Pooling Hazard Ratio (HR) with 95% CI showed that increasing CASC expression indicates worse overall survival (OS) (HR = 2.82, 95%CI: 1.76–4.52). The marked relationship were also uncovered between high CASC expression and advanced TNM stage (Odds Ratio (OR) = 2.38, 95%CI: 1.08–5.23), easier lymph node metastasis (OR = 2.38, 95%CI: 1.08–5.23, P = 0.0001) and easier distant metastasis (OR = 3.16, 95%CI: 1.62–6.15, P = 0.0007). In addition, the insignificant correlation or irrelevance between the expression of CASC and tumor size (OR = 1.33, 95%CI: 0.77–2.29), histological grade (OR = 0.70, 95%CI: 0.38–1.31), depth of invasion (OR = 2.74, 95%CI: 0.87–8.65), age (OR = 1.09, 95%CI: 0.71–1.68) and gender (OR = 0.97, 95%CI: 0.64–1.47) of CRC patients were also revealed. Sensitivity analysis and publication bias were performed through STATA 12.0 software, and insignificant publication bias was revealed.
Conclusion
High expression of CASC indicates a worse prognosis of colorectal cancer. LncCASC could be served as a potential prognostic indicator and a potential therapeutic target for colorectal cancer.