bluuebunny/crossref_metadata_2025 huggingface dataset:
Key Role of Dimensional Analysis Homogeneity in Proving Riemann Hypothesis and Providing Explanations on the Closely Related Gram Points
Authors: Ting John Y. C.
Published: May 2016

Riemann zeta function is the famous complex number infinite series consisting of a real and an imaginary part. Non-trivial zeros and Gram points are best seen as mathematically derived entities of this function when its variable Sigma has a value of $\frac{1}{2}$. The presence [but not the actual locations] of the complete set of infinite non-trivial zeros is characterized by the criterion that the sum total of the simultaneous real and imaginary parts in Riemann zeta function equates to zero. In an identical manner this slightly altered criterion for the presence [but not the actual locations] of the complete set of infinite Gram points is that this 'sum total' now refer to the lesser requirement that only the individual imaginary part in Riemann zeta function equates to zero. The key role played by Dimensional analysis homogeneity to rigorously prove Riemann conjecture/hypothesis has been fully outlined in our landmark research paper published earlier on Page 9 - 21 in the preceding Volume 8, Number 3, June 2016 issue of this journal. Those resulting methodology previously employed by us are now mathematically used in an analogical procedure to delineate its role in successfully supplying crucial explanations for Gram points. In this research article, we use the notation \{Non-critical lines\}-Gram points to signify those 'near-identical' (virtual) Gram points when Sigma value is not $\frac{1}{2}$.
EL DESDOBRAMIENTO DE LAS FUENTES DEL DERECHO
Authors: Almeida Patricia Martinez
Published: May 2016

Esta resenha traz algumas considerações acerca do livro “o transbordamento das fontes do direito” edição em espanhol na versão Kindle, de Antonio Enrique Pérez Luño, que discorre nessa obra sobre a problemática da aplicabilidade das fontes do direito na sociedade atual trazendo a lume o processo de mutação do sistema protetivo de direitos na evolução do Estado democrático de Direito.
A Folia de Reis “Fulô da Mantiqueira” do Município de Itajubá – MG na Perspectiva da Geografia Cultutal / The Folia de Reis “Fulô da Mantiqueira” of Itajubá - MG in Geographic Cultural Perspective
Authors: De Cássia Pereira Rosana , Branquinho Evanio Santos
Published: May 2016

A Folia de Reis Fulô da Mantiqueira localizada no município de Itajubá – MG é analisada levando em conta as questões de identidade, pertencimento, território e o processo de globalização da sociedade contemporânea. Este trabalho tem como objetivo relacionar a Folia de Reis com a Geografia Cultural e identificar a importância desta para a sociedade e o seu espaço, na busca de um maior reconhecimento desta manifestação folclórico-cultural. A metodologia utilizada foi a pesquisa qualitativa; no estudo de caso foi utilizada a história oral com entrevistas semiestruturadas para o melhor entrosamento com os entrevistados e assim ser possível obter informações mais ricas. Esta pesquisa foi feita sob o olhar de quem de alguma forma participa dessa manifestação, levando em conta a identidade cultural, religiosidade e simbolismo dos entrevistados.

Palavras-chave: Cultura; Folclore; Folia de Reis; Itajubá.

Abstract

The Fulô da Mantiqueira Folia de Reis is located in Itajubá, in state of Minas Gerais, it is analyzed considering certain issues such as identity, belonging, territory and the globalization process of contemporary society. This article aims to relate Folia de Reis with Cultural Geography and to identify its importance for society and its space, focusing on the recognition of this folkloric and cultural manifestation. In this paper was used a qualitative research method, in the study case was utilized oral stories with semi structured interviews in order to have a rapport with other participants, in this way it is possible to obtain richer information. This project was done by someone who participates of this event and it approaches cultural identity, religiosity and symbolisms of the interviewed.

Keywords: Culture; folklore; Folia de Reis; Itajubá.
A Flexible Calibration Approach for Cameras with Double-Sided Telecentric Lenses
Authors: Yao Linshen , Liu Haibo
Published: May 2016

With their constant perspective and large magnification in the working distance, double-sided telecentric lenses have been widely used in machine-vision applications. This paper puts forward a flexible calibration approach for the double-sided telecentric camera. Based on an orthographic projection model considering the major sources of lens distortions, a two-step calibration procedure is proposed. In this approach, the camera parameters apart from the lens distortions are achieved by a closed-form solution. Then a double non-linear optimization is performed to refine all the parameters, including the distortion coefficients and distortion centre. In addition, to achieve a flexible calibration procedure, the calibration pattern used is a cheap print product rather than a professional customized calibration pattern. Simulation and real-world experiments are performed to validate the performance of the proposed calibration approach. In addition, the comparison experiments between the print calibration pattern and professional calibration pattern are carried out, and the accuracy of calibration results are at the same level.
Editorial da Revista Digital do LAV
Authors: Oliveira Marilda Oliveira de , Charréu Leonardo , Nascimento Erinaldo Alves do
Published: May 2016

http://dx.doi.org/10.5902/1983734810651
Arte, poética, imagens, visualidades, jovens e performance no acontecimento cotidiano da cidade mundo
Authors: Filho Aldo Victorio
Published: May 2016

http://dx.doi.org/10.5902/1983734810725 Apresento, neste texto, as pesquisas desenvolvidas nos grupos de pesquisa (CNPq) Cultura Visual e Educação (UFG) e Estudos Culturais em Educação e Arte (UFRRJ e UERJ) e no programa de pós-graduação em artes da UERJ tendo como interesse investigativo a cultura visual, os jovens, as produções estéticas não legitimadas pelo sistema outorgado das artes, as poéticas corporais, as performances e performatividades ordinárias e marginais e o ensino formal e informal da arte no cotidiano. Constituir outras fontes epistêmicas que colaborem com a atualização do panorama de entendimento da criação estética, no mais amplo horizonte possível, na vida ordinária e, portanto, na formação humana é também nosso objetivo. Algumas das nossas perspectivas metodológicas e dos nossos referenciais teóricos são focalizados, esperando, dessa forma, abrir novas interlocuções que nos permitam coletivizar o que produzirmos de útil e ajustarmos o que for necessário. Recebido em: 23/09/2013 Aprovado em: 15/10/2013
Em processo: questões de uma investigação em/sobre deslocamentos
Authors: Nunes Aline
Published: May 2016

http://dx.doi.org/10.5902/1983734810730O texto que segue busca realizar conexões entre certos aspectos problematizados no decorrer do Colóquio Internacional de Educação e Visualidades, a partir das reflexões que emergem da investigação doutoral à qual me dedico. Procuro entrecruzar à temática do colóquio, “Incômodos”, meus interesses de pesquisa, na medida em que explicito alguns dos percursos realizados até então: a perspectiva narrativa autobiográfica, como possibilidade metodológica; a cultura visual enquanto posicionamento epistemológico; e os deslocamentos enquanto temática que permeia toda a discussão proposta na investigação doutoral. Recebido em: 23/09/2013 Aprovado em: 15/10/2013
Desapropriando o currículo: Imagem, prática educativa e experiência vivida no movimento anarcopunk
Authors: Remígio Maurício
Published: May 2016

http://dx.doi.org/10.5902/1983734810732Este texto apresenta aspectos de caminhos metodológicos percorridos numa pesquisa que busca compreender como experiências vividas fora da escola podem se imbricar na escola através da prática educativa. Discute, também, a relação aprendizagem/conhecimento como prática local que pressupõe considerar ações e significados do cotidiano. Práticas educativas inspiradas em experiências vividas no movimento anarcopunk – organizar-se coletivamente sem hierarquias – são utilizadas como estratégia de ensino. A coleta de dados foi realizada através de grupo focal, com cinco meninos e cinco meninas em uma escola pública municipal da cidade de Macapá – Amapá. Recebido em: 23/09/2013 Aprovado em: 15/10/2013
Cosplayers e animencontros: Os caminhos metodológicos de uma pesquisa de campo
Authors: Pereira Ilíada Damasceno
Published: May 2016

http://dx.doi.org/10.5902/1983734810734O presente artigo procura discutir os caminhos metodológicos de uma pesquisa qualitativa desenvolvida em dois animencontros realizados anualmente na cidade de Fortaleza, o SANA 2011 e o SANA Fest 2012. Tal pesquisa objetiva identificar e analisar as identidades e subjetividades construídas e desenvolvidas por meio da relação entre as visualidades da cultura pop japonesa presentes nos eventos e seus participantes. Para tanto, foram realizados, no primeiro evento, observação participante, anotações em diário de campo, registro de imagens e um grupo focal; no segundo animencontro, porém, a pesquisa ficou focada no acompanhamento de um grupo de cosplayers chamado Gold Project. Recebido em: 23/09/2013 Aprovado em: 15/10/2013
Entre a prática pedagógica e a prática artística: Reflexões sobre Arte e Arte Educação
Authors: Lampert Jociele , Nunes Carolina
Published: May 2016

http://dx.doi.org/10.5902/1983734814258 Este artigo aborda conceitos sobre o lugar do professor artista, bem como, deriva sobre o conceito de experiência utilizando o ateliê como espaço criativo, gerador de potência para articulações entre a formação docente e a prática artística. O estudo norteia-se sobre como o professor compõe seu processo criativo com a elaboração de cartografias, sendo que estas propoem fluxo e conexões entre os conceitos de espaço do ateliê e a subjetividade na prática docente do fazer/saber do professor artista. Desta forma, teoria e a prática tramam-se ao longo de perspectivas metodológicas, a fim de que, a própria pesquisa explore a narrativa subjetiva e identidade da professor artista. Recebido em: 05/06/2014Aprovado em: 15/12/2014
De fronteras, cuerpos y espacios liminales
Authors: Vidiella Judit
Published: May 2016

http://dx.doi.org/10.5902/1983734816718 El presente artículo aborda el interés creciente de la frontera como espacio de investigación en el arte, comprendida como ficción, construcción material y discursiva, espacio de regulación cultural, racial, económica, corporal... A través de proyectos artísticos videográficos como Performing the Border o Maquilapolis, se analizarán los dilemas y estrategias visuales y conceptuales que emergen en las políticas de re-presentación y documentalidad. Para analizar el caso de las maquiladoras situadas en la frontera entre Méjico y EUA, será fundamental abordar de forma compleja conceptos como ‘performance y ‘performatividad’ desde los Estudios de Performance, que aportan un análisis sobre la relación entre economía neoliberal, trabajo, cuerpo, género, sexualidad, capital y tecnología. Por otra parte, las aportaciones feministas señalan la importancia de las políticas de enunciación, representación y visibilidad, así como las prácticas de corporización mediante conceptos como ‘cyborg’, ‘identidades excéntricas’, ‘tecnologías del género’, etc. Recebido em: 13/10/2014Aprovado em: 15/12/2014
Dança e Cultura Pop
Authors: Berte Odailso Sinvaldo
Published: May 2016

Este estudo emerge com uma experiência artístico-pedagógica e reflete acerca da possibilidade de articular processos de ensino e criação de dança com imagens da cultura pop. A cultura pop pode ser compreendida como um nicho das chamadas pedagogias culturais, afeita a cativar os afetos dos corpos, possibilitar-lhes experiências de prazer e estimular, de diferentes modos, sua percepção e atuação no mundo. Trabalhar com tais elementos provindos das vivências dos estudantes constitui um desafio crítico e provocativo para o ensino de artes em geral e de dança em particular na contemporaneidade.
Historiando a mim mesmo: mo(vi)mentos de uma pesquisa autobiográfica e narrativa
Authors: Ferreira Luiz Carlos Pinheiro
Published: May 2016

O texto, de caráter autobiográfico e com ênfase em fragmentos narrativos, apresenta recorte da pesquisa de doutorado, concluída no Programa de Pós-Graduação em Arte e Cultura Visual da Faculdade de Artes Visuais da Universidade Federal de Goiás. Os resultados parciais estão organizados em mo(vi)mentos de investigação, numa perspectiva biográfico-narrativa que olha e analisa aspectos da vida pelo espelho retrovisor, construindo reflexões acerca de momentos da minha trajetória de vida e da minha atuação como docente no Departamento de Artes Visuais da Universidade de Brasília. A pesquisa de campo foi realizada com alunos-colaboradores do Curso de Licenciatura em Artes Visuais da referida universidade.
O mural de Eduardo Kobra em Santa Maria: diálogo ou imposição no espaço urbano
Authors: Uberti Mariete Tasquetto
Published: May 2016

Este artigo é um excerto da dissertação de Mestrado realizada junto ao Programa de Pós-graduação em Artes Visuais/UFSM, concluído em 2014. O qual versa sobre a Arte Pública em Santa Maria a partir de uma análise da obra de Eduardo Kobra com relação à arte local e os principais influenciadores no/para o campo da Arte Pública. Em cuja perspectiva, sobre a arte local, embasei-me em Folletto e Bisognin (2001). O artista é abordado pelo viés de sua relação com a arte nos espaços urbanos desde sua inserção no respectivo campo através da pichação aos projetos desenvolvidos na atualidade. A partir da contextualização da obra de Kobra em Santa Maria, objetivou-se fazer uma análise sobre suas reverberações para/na Arte Pública e a comunidade artística, mais especificamente aos grupos de artistas que produzem suas obras nos espaços urbanos municipais. Além de discorrer sobre as relações com o público e com os fomentadores de obras nos espaços públicos e seus condicionamentos ao selecionar obras e artistas para expor. O estudo, no decorrer das entrevistas e da análise do panorama local, mostrou-se pertinente pelas reflexões e questões que a obra trouxe a tona sobre o cenário artístico diante do embate entre as artes visuais e a atuação do poder público e das interações sociais que a obra possibilitou entre a Arte Pública e o público a partir de um reconhecimento da história local e sua arte.
Deslocamentos deleuzianos na pesquisa em artes visuais: estratégias para uma prática híbrida através da imagem
Authors: Bethonico Marina Romagnoli , Romagnoli Roberta Carvalho
Published: May 2016

Este artigo efetua uma reflexão sobre o método nas artes visuais contemporânea, propondo um diálogo com o filósofo Gilles Deleuze e seu plano de imanência. Tendo a imagem como fio condutor, rastreia o âmbito da produção artística atual, enfatizando o modo como os artistas concebem as sobrevivências da imagem. Em um contexto acadêmico que lida com a complexidade, o texto analisa como essa prática e seus processos fundamentam a construção de métodos de pesquisa singulares. Assim, considera-se ainda a capacidade da prática e da teoria de caminharem juntas, tendo como premissa fazer o fazer, pensar sobre o fazer, pensar sobre o pensar, fazer o pensar. Conclui-se que a imagem e o processo artístico são grandes potências de pesquisa na busca por um pensamento e uma prática da imagem que considere as diferenças.
StudioClio espaço de interações culturais: um olhar sobre a cultura, a arte e a gastronomia
Authors: Machado Ana Méri Zavadil
Published: May 2016

Este artigo integra estudos sobre Espaços Não Institucionais de Arte. O StudioClio é um espaço que enriquece a paisagem cultural de Porto Alegre. Multidisciplinar, atua em diversos segmentos: artes visuais, música, literatura, cinema, teatro, filosofia, história, moda e gastronomia. Neste texto, busca-se realizar um estudo sobre cultura, arte e gastronomia, tendo como foco duas atividades realizadas no StudioClio: o Almoço Cultural e o Banquete Cultural.
O ‘espaço’ da arte contemporânea em contextos educativos: confluências e interferências sócio-culturais
Authors: Valença Kelly Bianca Clifford
Published: May 2016

Este trabalho investiga o modo como seis alunos do curso de Licenciatura em Artes Visuais da Faculdade de Artes Visuais (FAV) da Universidade Federal de Goiás (UFG), compreendem e se relacionam com imagens da arte contemporânea como objeto de ensino. Inspirada na minha observação sobre a resistência ao uso destas imagens em salas de aula, esta pesquisa se configura como uma mostra de dados que constrói uma trama de opiniões que ora se entrecruzam, ora divergem, mas, sobretudo, refletem questões pedagógicas e sócio-culturais naturalizadas nas compreensões e concepções destes futuros professores. Uma metodologia qualitativa desenvolvida através de entrevistas individuais e grupos focais orientou esta investigação que considera imagens, falas, silêncios, gestos e reações como partes integrantes de uma análise crítica e construtiva de relatos que dialogam com a cultura visual.Palavras-chave:  arte contemporânea, ensino de arte, cultura visual.
A arte de ver o mundo com os próprios olhos. Mãos, narizes, ouvidos e línguas
Authors: Forte Marcelo
Published: May 2016

Esse artigo apresenta um relato de experiência de estágio supervisionado no curso de Artes Visuais – Licenciatura plena em Desenho e Plástica, com ênfase no terceiro semestre de inserção em sala de aula. Trabalhamos, professor e alunos, com a utilização de imagens da arte e de outros meios, de objetos sensoriais e da linguagem como produtores de sentidos para abordarmos os modos de ver e interpretar a imagem visual e escrita.
“Esse é o jeito Rebelde de ser”: Produzindo masculinidades nas salas de aula
Authors: Nunes Luciana Borre , Martins Raimundo
Published: May 2016

Este texto apresenta pesquisa que está sendo desenvolvida no Programa de Pós-Graduação em Arte e Cultura Visual na Faculdade de Artes Visuais da Universidade Federal de Goiás (Brasil). Os dados estão sendo coletados em uma escola da rede pública de Goiânia, Goiás, com estudantes do 3º ano do Ensino Fundamental. O estudo tem como foco discutir e analisar a constituição de masculinidades através do artefato visual: novela Rebeldes. A perspectiva pós-estruturalista embasa os referenciais teóricos da pesquisa. A investigação, de orientação qualitativa, se caracteriza como estudo do tipo etnográfico sendo utilizadas entrevistas, diário de campo, grupos focais e fotografias como material empírico. O texto discute como os discursos normativos da novela influenciam os comportamentos dos estudantes e seus relacionamentos sociais e como as práticas pedagógicas contribuem para a produção de masculinidades.
Mercado, coleções e interconexões: algumas pistas para compreender trocas comerciais via internet
Authors: Leitão Débora Krischke
Published: May 2016

O presente artigo parte de pesquisa realizada junto a compradores e vendedores que se relacionam através da Internet. Discutimos as trocas comerciais ali estabelecidas, oferecendo um contraponto à imagem de impessoalidade e instrumentalidade comumente atribuída à troca monetarizada. Procuramos mostrar o papel da honra e da confiança baseada na reputação para o grupo estudado, apontando relações que ultrapassam a mera circulação de dinheiro e mercadorias. Sublinhando a forte presença de colecionadoresenvolvidos em tais trocas, trazemos, igualmente, algumas reflexões sobre consumo e colecionismo, importantes para a compreensão das relações entre sujeitos e objetos no mundo contemporâneo.
Gordura trans e as definições concorrentes para o risco alimentar
Authors: David Marília Luz
Published: May 2016

Considerando-se os riscos alimentares contemporâneos, este artigo analisa a construção da gordura trans como risco, atentando para as versões concorrentes e criadas durante sua controvérsia científica. Esta controvérsia é analisada sob o viés de dois grandes arcos: o primeiro se estende pela década de 1990 e termina com o anúncio das primeiras legislações para regular a gordura trans em alimentos. Aqui estava em jogo a veracidade da relação entre gordura trans e os efeitos prejudiciais à saúde, e se autoridades nacionais de saúde iriam considerá-la um risco alimentar. As primeiras legislações para rotulagem da gordura trans iniciaram o fechamento de parte da controvérsia científica nesse sentido. O segundo arco é mais bem discutido e nele são destacadas as diferentes versões pelas quais o risco passou, conforme os atores participantes da controvérsia o atrelaram a diferentes aliados. Finalmente, o argumento seria que atualmente existem duas versões para o risco: um que define a gordura trans enquanto risco de saúde pública e outro promovido pela indústria que negocia o risco como responsabilidade do consumidor de zelar pela própria saúde, tendo em vista que, desde 2003 e 2004, esta passou a reconhecer a gordura trans como um risco e a incorporar o fato científico em seus produtos.
Algunas tendencias de la diferenciación del derecho en Chile
Authors: Cadenas Hugo
Published: May 2016

En este trabajo se aborda el problema de la diferenciación del sistema jurídico partir de un análisis sistémico, tomando el caso de Chile como un ejemplo. Teniendo en cuenta que se trata de una reflexión formal, aunque el análisis se ejemplifica con el caso chileno, muchas de las consideraciones que aquí se presentan se extiendan a otros países de América Latina. El texto presenta los conceptos básicos de la teoría de la diferenciación funcional, se discute el problema de la autonomía de la ley como una condición de diferenciación y se presentan las tendencias, cuestiones y la semántica del proceso producido en Chile. El artículo concluye con reflexiones sobre América Latina. http://dx.doi.org/10.5902/6385
Emerging Therapeutics for Radioiodide-Refractory Thyroid Cancer
Authors: Juan Pablo Nicola  , Ana María Masini-Repiso
Published: May 2016

Although uncommon, thyroid cancer constitutes the main endocrine neoplasia with an incidence rate that has been increasing steadily over the past decades. Recently, remarkable advances have occurred in understanding the biology of thyroid cancer. Novel germline and somatic point mutations as well as somatic chromosomal rearrangements associated with thyroid carcinogenesis have been discovered. Strikingly, acquired knowledge in the genetics of thyroid cancer has been translated into clinical practice, offering better diagnostic and prognostic accuracy and enabling the development of novel compounds for the treatment of advanced thyroid carcinomas. Even after 70 years, radioiodide therapy remains as the central treatment for advanced or metastatic differentiated thyroid cancer. However, the mechanisms leading to reduced radioiodide accumulation in the tumor cell remain partially understood. Radioiodide-refractory thyroid cancer metastasis constitutes a central problem in the management of thyroid cancer patients. In recent years, the antiangiogenic tyrosine kinase inhibitors sorafenib and lenvatinib have been approved for the treatment of advanced radioiodide-refractory thyroid carcinoma. Moreover, still on clinical phase of study, oncogene-specific and oncogene-activated signaling inhibitors have shown promising effects in recovering radioiodide accumulation in radioiodide-refractory thyroid cancer metastasis. Further clinical trials of these therapeutic agents may soon change the management of thyroid cancer. This review summarizes the latest advances in the understanding of the molecular basis of thyroid cancer, the mechanisms leading to reduced radioiodide accumulation in thyroid tumors and the results of clinical trials assessing emerging therapeutics for radioiodide-refractory thyroid carcinomas in the era of targeted therapies.
A Very Embarrassing Moment
Authors: Verpaelst Frank
Published: May 2016

I have dwarfism and blog mainly about disability related issues. This story is about the time a doctor exposed me to a room full of interns.
Disability is in the Eye of the Beholder
Authors: Verpaelst Frank
Published: May 2016

I have dwarfism and blog mainly about disability related issues. This story expresses my feelings about the label “disabled”.
La mort de mon père
Authors: Quintin Jacques
Published: May 2016

Le texte suivant consiste en le récit de la fin de vie de mon père, à la maison
sous les soins de ma mère, et illustre quelques enjeux éthiques, familiaux, de souffrance et
de sens. Ce récit permet de montrer que la maladie et la mort, loin de se réduire à un
problème à résoudre, deviennent un questionnement: qui sommes-nous, que devenons-nous? Plus
que tout, il y a cette question : que pouvons-nous espérer de ces expériences de
vie?
La conciliation travail-famille : le défi des mères médecins
Authors: Johnson Claude , Ravitsky Vardit
Published: May 2016

Les médecins, compte tenu des exigences de leur profession, présentent
d’importantes difficultés de conciliation travail-famille. Des mesures favorisant la
conciliation travail-famille seraient bénéfiques pour tous les médecins (particulièrement
pour les femmes), leurs enfants et leurs patients.
But the Pain Remains: A Response to Verpaelst
Authors: Raymond Marie-Hélène
Published: May 2016

People who experience chronic pain often refrain from expressing their pain overtly due to fear of stigmatization. Health professionals working with these persons may also find it challenging to face the persistent nature of their clients’ pain. Through his painting, Verpaelst helps to overcome these difficulties.
How Could Emergency Modify our Normal Ethics Standards? A Brief Review of Selected
Chapters in Emergency Ethics
Authors: St-Denis Karine
Published: May 2016

This review is about Emergency Ethics, the first in the four-volume series
Emergency Ethics, Law and Policy. It analyses chapters addressing the question: How
could emergency modify our normal ethics standards? The chapters offer three angles on the
question: conceptual analysis, empirical analysis and case study.
Discovery and validation of sub-threshold genome-wide association study loci using epigenomic signatures
Authors: Wang Xinchen , Tucker Nathan R , Rizki Gizem , Mills Robert , Krijger Peter HL , de Wit Elzo , Subramanian Vidya , Bartell Eric , Nguyen Xinh-Xinh , Ye Jiangchuan , Leyton-Mange Jordan , Dolmatova Elena V , van der Harst Pim , de Laat Wouter , Ellinor Patrick T , Newton-Cheh Christopher , Milan David J , Kellis Manolis , Boyer Laurie A
Published: May 2016

Genetic variants identified by genome-wide association studies explain only a modest proportion of heritability, suggesting that meaningful associations lie 'hidden' below current thresholds. Here, we integrate information from association studies with epigenomic maps to demonstrate that enhancers significantly overlap known loci associated with the cardiac QT interval and QRS duration. We apply functional criteria to identify loci associated with QT interval that do not meet genome-wide significance and are missed by existing studies. We demonstrate that these 'sub-threshold' signals represent novel loci, and that epigenomic maps are effective at discriminating true biological signals from noise. We experimentally validate the molecular, gene-regulatory, cellular and organismal phenotypes of these sub-threshold loci, demonstrating that most sub-threshold loci have regulatory consequences and that genetic perturbation of nearby genes causes cardiac phenotypes in mouse. Our work provides a general approach for improving the detection of novel loci associated with complex human traits.
Perception as a closed-loop convergence process
Authors: Ahissar Ehud , Assa Eldad
Published: May 2016

Perception of external objects involves sensory acquisition via the relevant sensory organs. A widely-accepted assumption is that the sensory organ is the first station in a serial chain of processing circuits leading to an internal circuit in which a percept emerges. This open-loop scheme, in which the interaction between the sensory organ and the environment is not affected by its concurrent downstream neuronal processing, is strongly challenged by behavioral and anatomical data. We present here a hypothesis in which the perception of external objects is a closed-loop dynamical process encompassing loops that integrate the organism and its environment and converging towards organism-environment steady-states. We discuss the consistency of closed-loop perception (CLP) with empirical data and show that it can be synthesized in a robotic setup. Testable predictions are proposed for empirical distinction between open and closed loop schemes of perception.
Decoding obesity in the brainstem
Authors: Cedernaes Jonathan , Bass Joseph
Published: May 2016

Neurons in the brainstem are the input for a neural circuit that integrates nutrient signals to control feeding behavior.
New insights into lithology and hydrogeology of the northern Newark Rift Basin
Authors: Zakharova N. V. , Goldberg D. S. , Olsen P. E. , Kent D. V. , Morgan S. , Yang Q. , Stute M. , Matter J. M.
Published: May 2016

The marginal facies of the Triassic rift basins in the eastern United States are poorly documented, particularly on the hinge or hanging wall margins. This study presents a lithological description and multiscale petrophysical analysis of basement rocks, overlying marginal facies of the early synrift strata, and the basal contact of the Palisade Sill that were drilled and cored in the northeastern part of the Newark Basin, near its terminus. The expression of the Stockton Formation differs from that in the central basin in having thinner layers, with uncertain temporal relationship to the type area. The bottom 50 m is lithologically distinct with brick‐red to dark‐purple mudstones and sandstones, abundant gypsum‐filled fractures, and a thin zone with anomalously high uranium concentration, not associated with organic‐rich mudstones as other occurrences in the basin. The crystalline basement is apparently Fordham gneiss, overlain by a thin sandstone layer and a dark‐purple hydrophilic mudstone. Despite the abundance of coarse‐grained strata and multiple sets of tectonic fractures, hydraulically transmissive zones are sparse, and do not uniquely correlate to fracture and/or matrix characteristics. Enhanced transmissivity may exist along intrusion boundaries due to enhanced thermal fracturing, but more hydraulic data are needed to verify it. Comparison of petrophysical data in two boreholes ∼210 m apart shows no direct correlation of individual lithological units and their hydraulic properties, although the overall formation characteristics are similar. The results highlight challenges for outcrop correlation at the marginal edges of the rift basins and estimating reservoir properties of these heterogeneous formations.
Mirror modes in the Earth's magnetosheath: Results from a global hybrid‐Vlasov simulation
Authors: Hoilijoki Sanni , Palmroth Minna , Walsh Brian M. , Pfau‐Kempf Yann , von Alfthan Sebastian , Ganse Urs , Hannuksela Otto , Vainio Rami
Published: May 2016

We investigate mirror mode structures in the Earth's magnetosheath using our global kinetic Vlasiator simulation, which models ion behavior through their distribution function and treats electrons as a charge‐neutralizing fluid. We follow the evolution of waves as they advect along velocity streamlines through the magnetosheath. We find that mirror mode waves are observed preferentially in the quasi‐perpendicular magnetosheath along velocity streamlines that enter the sheath in the vicinity of the foreshock ULF wave boundary where there are enough initial perturbations in the plasma for the mirror modes to grow, and the plasma properties fulfill the mirror instability condition better than elsewhere in the magnetosheath. We test selection criteria defined by previous studies and show that the spatial extent over which mirror modes occur ranges from much of the magnetosheath on the quasi‐perpendicular side of the subsolar point to very small isolated regions depending on the criteria.
Multidecadal freshening and lightening in the deep waters of the Bransfield Strait, Antarctica
Authors: Dotto Tiago S. , Kerr Rodrigo , Mata Mauricio M. , Garcia Carlos A. E.
Published: May 2016

The deep waters of the Bransfield Strait receive considerable amounts of water from the Weddell Sea continental shelf. The restricted connections to the surrounding ocean and relatively easier access makes the Bransfield Strait an important proxy region for monitoring changes in the dense Weddell Sea shelf water masses, which are an important precursor of Antarctic Bottom Water (AABW). Long‐term hydrographic data from the period 1960s–2010s showed freshening and lightening of the deep water masses of the Bransfield Strait, which was likely caused by large freshwater inputs originating from the western shelf of the Weddell Sea. The rates of freshening and lightening were −0.0010 ± 0.0005 yr−1 and −0.0016 ± 0.0014 kg m−3 yr−1 for the central basin, respectively, and −0.0010 ± 0.0006 yr−1 and −0.0029 ± 0.0013 kg m−3 yr−1 for the eastern basin, respectively. The deep waters showed a high degree of interannual thermohaline variability, which appeared to be caused by changes in the proportions of source water mass mixing between the years. Statistically significant negative correlations between salinity/neutral density fields and the Southern Annular Mode (SAM) were observed (−0.56 and −0.62 for the central basin, respectively, and −0.58 and −0.68 for the eastern basin, respectively) between 1980 and 2014. During SAM positive phases, communication between the Weddell Sea and the Bransfield Strait is reduced, which leads to less saline and lighter water masses in the Bransfield Strait; however, the opposite trends are observed during SAM negative phases.
Expedient Synthesis of Substituted Benzoheterocycles using 2‐Butoxy‐2,3‐dihydrofurans as [4+2] Benzannulation Reagents
Authors: Liu Changhui , Huang Wenbo , Wang Man , Pan Bin , Gu Yanlong
Published: May 2016

2‐Alkoxy‐2,3‐dihydrofurans were found to be versatile benzannulation reagents. Indoles can be synthesized in good to excellent yields via the [4+2] annulation of 2‐butoxy‐2,3‐dihydrofuran with pyrroles catalyzed by copper bromide. With the same protocol, carbazoles can also be obtained when indoles are used as starting material with the aid of p‐toluenesulfonic acid. This type of benzannulation reagent can also be used to synthesize benzofuran, benzothiophene and naphthalene derivatives in the presence of a catalytic amount of triflic acid in moderate yields. This benzannulation protocol features wide substrate scope and mild reaction condition. Moreover, most of examples have a good regioslectivity.

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Modeling bread baking with focus on overall deformation and local porosity evolution
Authors: Nicolas Vincent , Vanin Fernanda , Grenier David , Lucas Tiphaine , Doursat Christophe , Flick Denis
Published: May 2016

A two dimensional model of bread baking was developed including, for the first time, the dependence of dough viscosity on both temperature and moisture content, the carbon dioxide dissolved from liquid water together with gas generation from yeast at the beginning of baking and the shrinkage due to dough drying. Particular attention was paid to experimental validation of both overall and local variables such as local temperature, overall mass loss, and local moisture content, overall CO2 released into the oven, and overall deformation and local expansion or shrinkage. Sensitivity studies on generation of carbon dioxide, gravity, and shrinkage are presented to discuss their influences on bread geometry, porosity (reflecting the alveolar structure) and gas pressure. © 2016 American Institute of Chemical Engineers AIChE J, 62: 3847–3863, 2016
Preparation and performance of AMPS/AA/DMAA/SA copolymer as a filtrate reducer for oil well cementing
Authors: Tang Xin , Yuan Bin , Yang Yuanguang , Xie Yingquan
Published: May 2016

A new water‐soluble polymer was prepared and evaluated as a filtrate reducer for oil well cementing. The filtrate reducer (WSP) was synthesized from 2‐acrylamido‐2‐methylpropane sulfonic acid (AMPS), acrylic acid (AA), dimethyl acrylamide (DMAA), and sodium allylsulfonate (SA) by aqueous free radical polymerization. The synthesis conditions were optimized by orthogonal experiment. The molecule structure of the synthesized copolymer (WSP) was verified by Fourier transformer infrared spectrum (FTIR) and nuclear magnetic resonance hydrogen spectroscopy (1H‐NMR). The molecule weight of the synthesized copolymer was determined by gel permeation chromatography (GPC). The thermal stability of the synthesized copolymer was tested by thermogravimetry and differential thermogravimetry (TG and DTG). When the dosage of WSP is up to 3% in fresh water cement slurry, the FLAPIcan be controlled within 58 mL. In 37% salt water cement slurry, the FLAPIcan be controlled within 90 mL when the dosage of WSP is 5%. The thermal degradation of WSP is not obvious before 289 °C. Compared with a commercial filtrate reducer BS‐100L and a reported copolymer HTF200C, the WSP has better performance. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2016,133, 43824.
Biomass estimation in Pichia pastoris cultures by combined single‐wavelength fluorescence measurements
Authors: Brunner Vincent , Hussein Mohamed , Becker Thomas
Published: May 2016

In this work, the evolution of different biogenic fluorophores involved in the metabolism of Pichia pastoris was determined at four different single‐wavelength pairs (excitation/emission) during batch culture in microwell plates and used for effective and reliable biomass estimation by means of chemometric tools. The chemometric tools for biomass estimation were multiple linear regression (MLR), partial least squares regression (PLSR), and principal component regression (PCR). Variable importance in the projection (VIP) scores were used to rate the importance of model input variables, indicating tryptophan as the most important variable for biomass estimation. A direct correlation between the single fluorescence signals of tryptophan and biomass was additionally set up. Results indicate a successful fitting of the MLR, PLSR, PCR, and direct tryptophan correlation models for the present case and confirm the relevance of biogenic fluorophores for bioprocess state variables monitoring. The root mean squared error of prediction (RMSEP) between the predicted and measured values for the validation batches was 0.017, 0.023, 0.025, and 0.049 g L−1 dry cell weight for MLR, PLSR, PCR, and direct tryptophan correlation, respectively. The presented approach of indirectly measuring biomass based on combined single‐wavelength fluorescence measurements can be used for the development of a low‐cost alternative to 2D fluorescence spectroscopy. Biotechnol. Bioeng. 2016;113: 2394–2402. © 2016 Wiley Periodicals, Inc.
Engineered bacteria detect spatial profiles in glucose concentration within solid tumor cell masses
Authors: Panteli Jan T. , Forbes Neil S.
Published: May 2016

Tumor heterogeneity makes cancer difficult to treat. Many small molecule cancer drugs target rapidly dividing cells on the periphery of tumors but have difficulty in penetrating deep into tumors and are ineffective at treating entire tumors. Targeting both rapidly dividing and slower growing regions of tumors is essential to effectively treat cancer. A cancer drug carrier that penetrates deep into tumors and identifies metabolically activity could supply treatment to those areas based on the local microenvironment. We hypothesized that glucose sensing bacteria could identify sugar gradients in solid tumors. To test this hypothesis, a genetic circuit was designed to trigger expression of a green fluorescent protein (GFP) reporter through the chemotaxis‐osmoporin fusion protein, Trz1, a receptor for sensing glucose and ribose sugars. E. coli equipped with the Trz1‐GFP expression system, were administered to an in vitro model of a continuously perfused tumor tissue that mimics systemic delivery and clearance of bacteria through a blood vessel adjacent to a solid tumor. The level of GFP expressed, per bacterium, was time independent and indicated the glucose concentration as a function of penetration depth within the microfluidic tumors. The measured glucose concentration, correlated (P‐value = 2.6 × 10−5) with tumor cell viability as a function of depth. Mathematical analysis predicted drug delivery by glucose‐sensing bacteria would eliminate a higher percentage of the viable tumor cell population than a systemically administered drug. Glucose‐sensing bacteria could deliver cancer therapies with increased drug penetration and nutrient‐dependent dosing to continuously treat viable regions of cancer tissue that have a higher prevalence for metastatic dissemination. Biotechnol. Bioeng. 2016;113: 2474–2484. © 2016 Wiley Periodicals, Inc.
Pentamethylcyclopentadienyl Iridium(III) Metallacycles Applied to Homogeneous Catalysis for Fine Chemical Synthesis
Authors: Michon Christophe , MacIntyre Kirsty , Corre Yann , Agbossou‐Niedercorn Francine
Published: May 2016

Pentamethylcyclopentadienyl cyclometallated complexes have been used to catalyse a variety of organic transformations over the last decades. However, the huge potential of pentamethylcyclopentadienyl iridacycles has only been truly recognised in recent years. Indeed, an upsurge of reports on such new half‐sandwich iridium(III) metallacycles has been observed. The application of these organometallic complexes in various homogeneous catalysed organic reactions has led to the development of environmentally and economically beneficial routes towards important and highly functionalised fine chemicals. Studied reactions include hydrogenation, amine alkylation, dehydrogenation, oxidation and hydrofunctionalisation reactions as well as dynamic kinetic resolutions (DKR). This minireview focusses specifically on the recent applications of half‐sandwich iridium(III) metallacycles in such processes.
Tuning Optical Properties of Encapsulated Clusters of Gold Nanoparticles through Stimuli‐Triggered Controlled Aggregation
Authors: Dergunov Sergey A. , Kim Mariya D. , Shmakov Sergey N. , Richter Andrew G. , Weigand Steven , Pinkhassik Eugene
Published: May 2016

Gold nanoparticles entrapped in the hollow polymer nanocapsules undergo pH‐mediated controlled aggregation. Encapsulated clusters of nanoparticles show absorbance at higher wavelengths compared with individual nanoparticles. The size of the aggregates is controlled by the number of nanoparticles entrapped in individual nanocapsules. Such controlled aggregation may permit small biocompatible nanoparticles exhibit desirable properties for biomedical applications that are typically characteristic of large nanoparticles.
ChemInform Abstract: SOLVENT EFFECTS ON THE BORON‐11 AND PROTON NMR SPECTRA OF DECABORANE(14), B10H14
Authors: GAINES D. F. , NELSON C. K. , KUNZ J. C. , MORRIS J. H. , REED D.
Published: May 2016

Für Borane unerwartet starke Einflüsse der Natur des Lösungsmittels auf die chemischen Verschiebungen in den NMR‐Spektren wurden für B10H14 gefunden [Messungen an vorwiegend gesättigten Lösungen in C6D6, CD2Cl2, THF‐d8, Aceton‐d6, CD3CN, n‐Pentan etc.].
ChemInform Abstract: STRUCTURAL STUDIES OF SALTS OF CIS AND TRANS μ‐FLUORO‐BRIDGED POLYMERS OF PENTAFLUOROGERMANATE(1‐) AND OF THE PENTAFLUOROGERMANATE(1‐) MONOMER
Authors: MALLOUK T. E. , DESBAT B. , BARTLETT N.
Published: May 2016

Im Hinblick auf die Stabilisierung des GeF5‐‐Anions durch Kationen wurden Kristall‐ und Molekularstrukturen sowie Schwingungsspektren (Raman, IR) von XeF5+ GeF5‐ (orthorhombisch, Pmnb, Z=4) und der neuen Verbindung ClO2+ GeF5‐ (orthorhombisch, C2221, Z=8) untersucht.
ChemInform Abstract: POLARIZED NEUTRON DIFFRACTION AND MOESSBAUER EFFECT STUDY OF THE MAGNETIC ORDERING IN WUSTITE, FEYO
Authors: WILKINSON C. , CHEETHAM A. K. , LONG G. J. , BATTLE P. D. , HOPE D. A. O.
Published: May 2016

Neutronenbeugungsmessungen bei 45 K an Proben mit y = 0.926 und y = 0.943 zeigten Erhaltung der antiferromagnetischen Ordnung in der Nähe von Defektclustern.
ChemInform Abstract: X‐RAY PHOTOELECTRON SPECTROSCOPIC STUDY OF THE RHODIUM ELECTRODE SYSTEM IN ACID
Authors: HALL H. Y. , SHERWOOD P. M. A.
Published: May 2016

Rh‐Elektroden in 0.5 M H3SO4 zeigten während stationärer Polansierung Bildung von oxidiertem Rh(III) bei niedrigen und Rh(IV) bei höheren Potentialen (ls‐Spektren von O).
ChemInform Abstract: KINETICS OF THE STEPWISE OXIDATION OF MANGANESE(II) BY PEROXODIPHOSPHATE (PDP) IN AQUEOUS PERCHLORIC ACID. CATALYSIS BY SILVER(I)
Authors: RAO K. J. M. , VITTAL A. S. P. , RAO P. V. K.
Published: May 2016

Die Kinetik der Oxidation von Mn(II) zu Mn(VII) wird bei [Mn(II)] [PDP] und l = 0.58 Muntersucht, um Einblick in die Natur der intermediären Oxidationszustände des Mn zu bekommen.
ChemInform Abstract: KINETICS AND MECHANISM OF HUEBNERITE (MNWO4) AND FERBERITE (FEWO4) CRYSTALLIZATION UNDER HYDROTHERMAL CONDITIONS
Authors: BUHL J. CHR. , WILLGALLIS A.
Published: May 2016

Hydrothermalreaktionen zwischen den Metall(ll)‐chloriden und Na‐wolframat in einem Autoklaven bei 300 und 400°C und l kbar zeigten eine höhere Bildungsrate für Hübnerit, die auch mit der Temp. stärker anstieg.
ChemInform Abstract: CHALCOGEN FLUORIDES IN LOWER DEGREES OF OXIDATION. IX. PREPARATION AND CHARACTERIZATION OF 1,3‐DIFLUOROTRISULFANE 1,1‐DIFLUORIDE (SF3SSF)
Authors: WILLNER H.
Published: May 2016

Die neue Titelverbindung entsteht bei der Kondensation von SP2 und SSFQ in geringen Ausbeuten (einige %, neben dem Hauptprodukt SF3SF).
ChemInform Abstract: PHOSPHORUS OXIDE (P4O7): A NEW SYNTHESIS METHOD, STRUCTURAL DATA AND CHARACTERIZATION BY VIBRATIONAL SPECTROSCOPY
Authors: MOEBS M. + , JANSEN M.
Published: May 2016

Die Darstellung von reinem P407 in Form glasklarer stäbchenförmiger Kristalle gelang in einem Schritt durch Oxydation von P4O6 im geschlossenen System unter "sauerstoffgepufferter" Atmosphäre.
ChemInform Abstract: HALIDE ABSTRACTION FROM TITANIUM(III) CHLORIDE BY ZINC CHLORIDE
Authors: FOLTING K. , HUFFMAN J. C. , BANSEMER R. L. , CAULTON K. G.
Published: May 2016

Nach (Nicht‐Redox‐)Reaktion von (I) mit (II) in THF erhaltene blaugrüne Kristalle von ( III) sind orthorhombisch mit P212121 und Z=4.
ChemInform Abstract: REACTION OF TRITHIAZYL CHLORIDE WITH TITANIUM TETRACHLORIDE. CRYSTAL STRUCTURE OF (S4N5)2(TI2CL10)
Authors: EICHER J. , KLINGELHOEFER P. + , MUELLER U. + , DEHNICKE K.
Published: May 2016

Die Titelverbindung (IV) wird gemäß Formelschema als ein Nebenprodukt der Umsetzung von Trithiazylchlorid mit TiCl4 in CCl4 in Form brauner Nadeln erhalten (keine Ausb.‐Angabe).
ChemInform Abstract: STEREOSELECTIVE NUCLEOPHILIC ACYLATION OF BENZALDEHYDE WITH A CROTONALDEHYDE‐D1 REAGENT
Authors: BRAUN M. , HILD W.
Published: May 2016

Der aus (S)‐Milchsäureester zugängliche Aldehyd (I) wird in das Vinylsulfid (IIa) übergeführt, das nach Lithiierung zu (IIb) mit Benzaldehyd (III) mit hoher Stereoselektivität das Addukt (IVa) als Hauptprodukt liefert.
ChemInform Abstract: META/PARA‐SELECTIVITY VARIATION BY SULFIDE‐SULFOXIDE CONVERSION OF 6‐SUBSTITUTED β‐CYCLODEXTRIN. HYDROLYSES OF NITROPHENYL ACETATES
Authors: FUJITA K. , EJIMA S. , UEDA T. , IMOTO T. , SCHULTEN H.‐R.
Published: May 2016

β‐Cyclodextrin‐ö‐monotosylat (I) tauscht mit Mercaptanen (II) zu den Thioethern (III) aus, die zu den Sulfoxiden (IV) oxidiert werden.
ChemInform Abstract: A NOVEL REGIOSPECIFIC INTRAMOLECULAR CYCLOADDITION OF AN AROMATIC RING. MOLECULAR ORBITAL STUDY OF CONJUGATED KETENES THERMALLY GENERATED FROM SIX‐MEMBERED α‐MONOCARBONYL AZO COMPOUNDS
Authors: KUZUYA M. , MIYAKE F. , OKUDA T.
Published: May 2016

Beim langsamen Erwärmen des aus (I) hergestellten Phthalazinons (II) entsteht aus dem chinoiden Keten (III)durch [."4a + "Zal 30 Cycloaddition und nachfolgende Cope‐Umlagerung das Benzazulenon (V).
ChemInform Abstract: 1‐CHLORO‐1,3‐BIS(DIMETHYLAMINO)‐2‐AZAPROPENYLIUM SALTS: INTERMEDIATES FOR THE SYNTHESIS OF 1,3,5‐TRIAZINES, PYRIMIDINES, ISOQUINOLINES, QUINAZOLINES, AND A 1,3,5‐THIADIAZINIUM SALT
Authors: BOYD G. V. , LINDLEY P. F. , NICOLAOU G. A.
Published: May 2016

Die im Titel genannten Salze (I) reagieren zu Heterocyclen (III), (V), (VI) und (X).
ChemInform Abstract: ACTIVATION OF CHEMICAL REACTION BY IMPACT OF MOLECULES ON A SURFACE 2. THE DECOMPOSITION OF TETRAMETHYLDIOXETANE
Authors: BOTTARI F. J. , GREENE E. F.
Published: May 2016

Tetramethyldioxetan‐(TM D)‐Moleküle wurden in einem Überschallstrahl mit H2 als Trägergas auf kinetische Energien von 170 kJ/mol beschleunigt.