bluuebunny/crossref_metadata_2025 huggingface dataset:
Bisoprolol protects myocardium cells against ischemia/reperfusion injury by attenuating unfolded protein response in rats
Authors: Zhang Chengcheng , He Songqing , Li Yanming , Li Feng , Liu Zhengbing , Liu Jing , Gong Jianbin
Published: September 2017

Bisoprolol (B) exerts potential cardioprotective effects against myocardial ischemia/reperfusion (I/R) injury. Unfolded protein response (UPR) attenuates I/R injury induced apoptosis by reducing oxidative damage and inflammation response. The current study investigated whether the protective effects of bisoprolol resulted from modulating UPR and anti-inflammatory during myocardial I/R condition and elucidated its potential mechanisms. Sprague-Dawley rats were treated with B in the absence or presence of the injected UPR activator dithiothreitol (DTT) and then subjected to myocardial I/R surgery. In vitro, cultured H9C2 cells were pretreated with B or DTT and then subjected to simulate ischemia reperfusion (SIR) operation. Bisoprolol conferred cardioprotective effects by improving postischemic cardiac function, decreasing infarct size, reducing apoptotic index, diminishing serum creatine kinase and lactate dehydrogenase levels, suppressing TNF-α and IL-6 secretion, inhibiting UPR signal pathways and downregulating caspase-12 and caspase-3 expressions. Consistently, B conferred similar antioxidative and anti-inflammatory effects against SIR injury in cultured H9C2 cardiomyocytes. Pretreatment with DTT or C/EBP homologous protein (CHOP) overexpression mediated by lentivirus administration both abolished these effects. In summary, our results demonstrate that Bisoprolol protects myocardium cells against ischemia/reperfusion injury partly by attenuating unfolded protein response.
Google Analytics and quick response for advancement of gold nanoparticle-based dual lateral flow immunoassay for malaria – Plasmodium lactate dehydrogenase (pLDH)
Authors: Mthembu Christian L. , Sabela Myalowenkosi I. , Mlambo Mbuso , Madikizela Lawrence M. , Kanchi Suvardhan , Gumede Halalisani , Mdluli Phumlane S.
Published: September 2017

An assay with quick response barcodes improves malaria diagnosis, and enhances systems transferring data among community healthcare workers.
Recent research progress in non-aqueous potassium-ion batteries
Authors: Zou Xiaoxi , Xiong Peixun , Zhao Jin , Hu Jimin , Liu Zhitian , Xu Yunhua
Published: September 2017

The recent research progress in non-aqueous potassium-ion batteries is summarized and the challenges and future research opportunities are briefly discussed.
Dynamics of excited state proton transfer in nitro substituted 10-hydroxybenzo[h]quinolines
Authors: Marciniak H. , Hristova S. , Deneva V. , Kamounah F. S. , Hansen P. E. , Lochbrunner S. , Antonov L.
Published: September 2017

Barrierless proton transfer in HBQ and a barrier upon nitro substitution.
The fountain effect of ice-like water across nanotubes at room temperature
Authors: Zhao Kuiwen , Wu Huiying
Published: September 2017

Ice-like ordered water in nanotubes induces an unexpected fountain flow under a small temperature difference due to the collective motion of ice-like ordered water molecules, which effectively converts heat to mechanical work without dissipation.
Voltammetric and spectroscopic study of ferrocene and hexacyanoferrate and the suitability of their redox couples as internal standards in ionic liquids
Authors: Frenzel Ninett , Hartley Jennifer , Frisch Gero
Published: September 2017

The hexacyanoferrate(iii/ii) redox couple is useful as a complementary redox standard with ferrocenium/ferrocene because in many instances only one of these couples exhibits reversible behaviour.
Preparation and characterization of CrFeWTiO2 photoanodes and their photoelectrochemical activities for water splitting
Authors: Momeni Mohamad Mohsen , Ghayeb Yousef , Shafiei Mojgan
Published: September 2017

The chemical bath deposition (CBD) method was successfully applied to prepare WTiO2 nanotube arrays co-deposited with chromium, iron and chromium–iron nanoparticles.
Carbon nanospheres derived from Lablab purpureus for high performance supercapacitor electrodes: a green approach
Authors: Ali Gomaa A. M. , Divyashree A. , Supriya S. , Chong Kwok Feng , Ethiraj Anita S. , Reddy M. V. , Algarni H. , Hegde Gurumurthy
Published: September 2017

Carbon nanospheres prepared fromLablab purpureususing a green approach showed high capacitance (300 F g−1) and stability (94%).
Syntheses, crystal structures and magnetic properties of two mixed-valence Co(iii)Co(ii) compounds derived from Schiff base ligands: field-supported single-ion-magnet behavior with easy-plane anisotropy
Authors: Mandal Shuvankar , Mondal Suraj , Rajnák Cyril , Titiš Ján , Boča Roman , Mohanta Sasankasekhar
Published: September 2017

Positive D values and slow magnetic relaxation with two relaxation channels have been observed in two CoIIICoII compounds derived from imino-amino-phenol ligands.
Coexistence of long-range antiferromagnetic order and slow relaxation of the magnetization in the first lanthanide complex of a 1,2,4-benzotriazinyl radical
Authors: Morgan Ian S. , Mansikkamäki Akseli , Rouzières Mathieu , Clérac Rodolphe , Tuononen Heikki M.
Published: September 2017

We have synthesised and characterised the compound Dy(1)(tbacac)3 (2), the first lanthanide complex of a new coordinating 1,2,4-benzotriazinyl radical (1).
[TcII(NO)(trifluoroacetate)4F]2−– synthesis and reactions
Authors: Balasekaran S. M. , Hagenbach A. , Drees M. , Abram U.
Published: September 2017

Cs(NBu4)[Tc(NO)(OOCCF3)4F] can act as a precursor for the synthesis of further Tc(ii) and Tc(i) nitrosyl complexes with trifluoroacetato or fluorido ligands. The Tc(i) compounds show unusual99Tc NMR chemical shifts.
2D carboxylate-bridged LnIII coordination polymers: displaying slow magnetic relaxation and luminescence properties in the detection of Fe3+, Cr2O72− and nitrobenzene
Authors: Gao Wei , Liu Feng , Zhang Bao-Ying , Zhang Xiu-Mei , Liu Jie-Ping , Gao En-Qing , Gao Qing-Yu
Published: September 2017

Carboxylate-bridged Ln-CPs were obtained. 1-Dy shows slow magnetic relaxation. 1-Eu (or 1-Tb) exhibits multifunctional luminescence properties i.e., detecting Fe3+, Cr2O72− and nitrobenzene.
Catalyst-free room-temperature iClick reaction of molybdenum(ii) and tungsten(ii) azide complexes with electron-poor alkynes: structural preferences and kinetic studies
Authors: Schmid Paul , Maier Matthias , Pfeiffer Hendrik , Belz Anja , Henry Lucas , Friedrich Alexandra , Schönfeld Fabian , Edkins Katharina , Schatzschneider Ulrich
Published: September 2017

The azide complexes [M(η3-allyl)(N3)(bpy)(CO)2] with M = Mo, W smoothly react in a [3 + 2] cycloaddition reaction with electron-poor alkynes.
Gate-opening upon CO2 adsorption on a metal–organic framework that mimics a natural stimuli-response system
Authors: Tseng T. W. , Lee L. W. , Luo T. T. , Chien P. H. , Liu Y. H. , Lee S. L. , Wang C. M. , Lu K. L.
Published: September 2017

A dynamic d-champhorate-based protuberant-grid-type framework, undergoes gate opening and closing processes that were triggered by the stimuli of the adsorption or desorption of CO2. It is able to specifically recognize CO2 over than N2 and H2 and shows a high CO2 uptake of 90 mg g−1 under 35 bar at 298 K.
Correction: Lactobacillus casei CCFM419 attenuates type 2 diabetes via a gut microbiota dependent mechanism
Authors: Wang Gang , Li Xiangfei , Zhao Jianxin , Zhang Hao , Chen Wei
Published: September 2017

Correction for ‘Lactobacillus casei CCFM419 attenuates type 2 diabetes via a gut microbiota dependent mechanism’ by Gang Wang et al., Food Funct., 2017, DOI: 10.1039/c7fo00593 h.
The power of solid supports in multiphase and droplet-based microfluidics: towards clinical applications
Authors: Serra M. , Ferraro D. , Pereiro I. , Viovy J.-L. , Descroix S.
Published: September 2017

This review focuses on devices developed for the manipulation of functionalized particles as solid-support in multiphase and droplet microfluidic systems, and on their clinical applications.
Subcellular compartmentalisation of copper, iron, manganese, and zinc in the Parkinson's disease brain
Authors: Genoud Sian , Roberts Blaine R. , Gunn Adam P. , Halliday Glenda M. , Lewis Simon J. G. , Ball Helen J. , Hare Dominic J. , Double Kay L.
Published: September 2017

Altered iron and copper levels in the Parkinson's disease substantia nigra are confined to the cytosolic compartment of the cell.
Experimental and computational investigation of the substituent effects on the reduction of Fe3+by 1,2-dihydroxybenzenes
Authors: Salgado Pablo , Contreras David , Mansilla Héctor D. , Márquez Katherine , Vidal Gladys , Cobos Carlos J. , Mártire Daniel O.
Published: September 2017

This study reports on the kinetics of the early steps of the reactions between substituted 1,2-dihydroxybenzenes (1,2-DHB) and Fe3+.
Multicomponent synthesis of new curcumin-based pyrano[2,3-d]pyrimidine derivatives using a nano-magnetic solid acid catalyst
Authors: Panahi Farhad , Niknam Esmaeil , Sarikhani Samira , Haghighi Fatemeh , Khalafi-Nezhad Ali
Published: September 2017

An novel nano-magnetic solid acid catalyst was used for the efficient synthesis of new curcumin-based pyrano[2,3-d]pyrimidine derivatives via a multicomponent reaction under mild conditions.
Composites of hierarchical metal–organic framework derived nitrogen-doped porous carbon and interpenetrating 3D hollow carbon spheres from lotus pollen for high-performance supercapacitors
Authors: Xin Lijun , Chen Rongrong , Liu Qi , Liu Jingyuan , Li Zhanshuang , Li Rumin , Wang Jun
Published: September 2017

Nitrogen-doped porous carbon prepared via facile carbonization which displays high specific capacitance, is an excellent potential material for supercapacitors.
Cu2+-Mediated turn-on fluorescence assay for sulfide ions using glutathione-protected gold nanoclusters: enhanced sensitivity, good reusability, and cell imaging
Authors: Li Sha , Feng Jiayu , Huang Pengcheng , Wu Fangying
Published: September 2017

Cu2+-Mediation enables turn-on fluorescence detection of S2−using GSH-Au NCs with good sensitivity, reusability, and applicability in cell imaging.
Novel supramolecular sensors constructed from pillar[5]arene and a naphthalimide for efficient detection of Fe3+ and F− in water
Authors: Lin Qi , Mao Peng-Peng , Zheng Feng , Liu Lu , Liu Juan , Zhang You-Ming , Yao Hong , Wei Tai-Bao
Published: September 2017

Novel water soluble supramolecular sensors for efficient detection of Fe3+ and F− were constructed by assembling a novel naphthalimide and pillar[5]arene.
Mechanism for the SNAr reaction of atrazine with endogenous thiols: experimental and theoretical study
Authors: Calfumán K. , Gallardo-Fuentes S. , Contreras R. , Tapia R. A. , Campodónico P. R.
Published: September 2017

The mechanism for the SNAr reaction of atrazine with endogenous thiols: a stepwise or concerted process?
Confined NaAlH4 nanoparticles inside CeO2 hollow nanotubes towards enhanced hydrogen storage
Authors: Gao Qili , Xia Guanglin , Yu Xuebin
Published: September 2017

CeO2 nanotubes have been adopted as functional scaffolds to support NaAlH4 nanoparticles towards enhanced hydrogen storage performance.
Cellular behavior controlled by bio-inspired and geometry-tunable nanohairs
Authors: Heo Chaejeong , Jeong Chanho , Im Hyeon Seong , Kim Jong Uk , Woo Juhyun , Lee Ji Yeon , Park Byeonghak , Suh Minah , Kim Tae-il
Published: September 2017

Vertical and stooped nanohair structures can facilitate the control of cell viability and guide directional migration for biomedical applications.
Capabilities of transition metals in retarding the bonding of carbon atoms to minimize dendritic graphene
Authors: Zhu Zhenwei , Zhan Linjie , Wan Wen , Zhao Zhijuan , Shih Tien-Mo , Cai Weiwei
Published: September 2017

We have synthesized zigzag-edged hexagonal graphene domains by transition-metal-driven catalytic assistance via low pressure CVD.
Synthesis of long hierarchical MoS2nanofibers assembled from nanosheets with an expanded interlayer distance for achieving superb Na-ion storage performance
Authors: Gao Zhonggui , Yu Xiao , Zhao Jiang , Zhao Wenxia , Xu Ruimei , Liu Yong , Shen Hui
Published: September 2017

A PVP-assisted strategy was developed to prepare long hierarchical MoS2nanofibers with an expanded (002) interlayer for achieving superb Na-ion storage.
Driving and photo-regulation of myosin–actin motors at molecular and macroscopic levels by photo-responsive high energy molecules
Authors: Menezes Halley M. , Islam Md. Jahirul , Takahashi Masayuki , Tamaoki Nobuyuki
Published: September 2017

Azobenzene based non-nucleoside triphosphates, AzoTPs, drive and photo-regulate the myosin–actin motor function at both molecular and macroscopic levels.
Iridium-catalyzed direct C–H amidation of anilines with sulfonyl azides: easy access to 1,2-diaminobenzenes
Authors: Wang Lianhui , Yang Zi , Yang Mengqi , Zhang Rongyi , Kuai Changsheng , Cui Xiuling
Published: September 2017

The Ir(iii)-catalyzed C–H amidation of anilines with azides is achieved, and the 2-pyrimidyl and sulfonyl moieties could be removed, offeringortho-diaminobenzenes.
Metal-free C–H functionalization of 2H-imidazole 1-oxides with pyrrolyl fragments in the design of novel azaheterocyclic ensembles
Authors: Varaksin Mikhail , Moseev Timofey , Chupakhin Oleg , Charushin Valery , Trofimov Boris
Published: September 2017

Novel pyrrolyl-2H-imidazoles have been synthesizedviametal-free C–H/C–H coupling reactions under mild conditions and in good to excellent yields.
Elemental sulfur as a sulfuration agent in the copper-catalyzed C–H bond thiolation of electron-deficient arenes
Authors: Yan Haiming , Huang Zhiliang , Chen Meng , Li Cuiting , Chen Ya , Gao Meng , Lei Aiwen
Published: September 2017

By utilizing elemental sulfur as the thiolation agent and oxidant, a copper-catalyzed direct C–H bond thiolation of electron-deficient arenes was demonstrated.
Entirely recombinant protein-based hydrogels for selective heavy metal sequestration
Authors: Kou Songzi , Yang Zhongguang , Luo Jiren , Sun Fei
Published: September 2017

Green mining and heavy metal remediation enabled by metalloprotein hydrogels.
Thickness- and temperature-dependent structural and electromechanical properties of (100)-oriented Sc-doped (Na0.85K0.15)0.5Bi0.5TiO3 ferroelectric films
Authors: Wu Yunyi , Hu Yonghong , Wang Xiaohui , Zhong Caifu , Li Longtu
Published: September 2017

NKBT-Sc film thickness- and LNO layer insertion mode-dependent structural and electromechanical properties of the composite films were investigated.
Aconitic acid derived carbon dots as recyclable “on–off–on” fluorescent nanoprobes for sensitive detection of mercury(ii) ions, cysteine and cellular imaging
Authors: Zhao Fengjiao , Qian Jiali , Quan Feifei , Wu Chengxin , Zheng Yian , Zhou Lei
Published: September 2017

Aconitic acid is used as a new precursor for fabricating CDs and developing a sensitive “on–off–on” sensor for Hg2+, Cys and cellular imaging.
Ternary Eu(iii) and Tb(iii) β-diketonate complexes containing chalcones: photophysical studies and biological outlook
Authors: Abbas Zafar , Dasari Srikanth , Patra Ashis K.
Published: September 2017

Ternary Eu(iii) and Tb(iii) β-diketonate complexes containing chalcones were studied for their structures, photophysical properties, interactions with DNA and serum protein, and photo-induced DNA cleavage activity.
Multi-dimensional charge transport in supramolecular helical foldamer assemblies
Authors: Méndez-Ardoy Alejandro , Markandeya Nagula , Li Xuesong , Tsai Yu-Tang , Pecastaings Gilles , Buffeteau Thierry , Maurizot Victor , Muccioli Luca , Castet Frédéric , Huc Ivan , Bassani Dario M.
Published: September 2017

Helical aromatic foldamers are bioinspired architectures that combine through-bond and through-space charge transport in a single molecule.
Achieving enhanced cell penetration of short conformationally constrained peptides through amphiphilicity tuning
Authors: Tian Yuan , Zeng Xiangze , Li Jingxu , Jiang Yanhong , Zhao Hui , Wang Dongyuan , Huang Xuhui , Li Zigang
Published: September 2017

We synthesized a panel of conformationally constrained peptides with either α-helix or β-hairpin conformations. We tuned the amphiphilicity of these constrained peptides with different distributions of charged or hydrophobic residues and compared their cellular uptake efficiencies in different cell lines.
Pentaerythritol based push–pull tetramers for organic photovoltaics
Authors: Labrunie Antoine , Josse Pierre , Dabos-Seignon Sylvie , Blanchard Philippe , Cabanetos Clément
Published: September 2017

We report herein the synthesis, characterization and preliminary evaluation of two simple tetramers based on the functionalization of a central pentaerythritol σ-linker with push–pull chromophores as molecular donor for organic photovoltaics.
Solution-processable antimony-based light-absorbing materials beyond lead halide perovskites
Authors: Boopathi Karunakara Moorthy , Karuppuswamy Priyadharsini , Singh Anupriya , Hanmandlu Chintam , Lin Lin , Abbas Syed Ali , Chang Chien Cheng , Wang Pen Cheng , Li Gang , Chu Chih Wei
Published: September 2017

Lead-free antimony based metal halide perovskites were used as photoactive materials in solar cell devices and exhibited maximum power conversion efficiency of 2.04%.
Efficient and thermally stable inverted perovskite solar cells by introduction of non-fullerene electron transporting materials
Authors: Heo Jin Hyuck , Lee Seung-Chul , Jung Su-Kyo , Kwon O-Pil , Im Sang Hyuk
Published: September 2017

Highly efficient and thermally stable inverted MAPbI3 and FAPbI3−xBrx perovskite planar solar cells are demonstrated by using a N,N′-bis(phenylmethyl)naphthalene-1,4,5,8-tetracarboxylicdiimide (NDI-PM)-based electron transporting material (ETM) instead of a conventional PCBM-based ETM.
Three-dimensional and ultralight sponges with tunable conductivity assembled from electrospun nanofibers for a highly sensitive tactile pressure sensor
Authors: Xu Tao , Ding Yichun , Wang Zhao , Zhao Yong , Wu Weidong , Fong Hao , Zhu Zhengtao
Published: September 2017

A three-dimensional conductive sponge made of electrospun nanofibers can be used in the design of a highly sensitive tactile pressure sensor.
MiR-138 protects cardiac cells against hypoxia through modulation of glucose metabolism by targetting pyruvate dehydrogenase kinase 1
Authors: Zhu Hang , Xue Hao , Jin Qin-Hua , Guo Jun , Chen Yun-Dai
Published: September 2017

Dysfunction of cardiac cells under hypoxia has been identified as an essential event leading to myocytes functional failure. MiRNAs are importantly regulatory small-noncoding RNAs that negatively regulate gene expression through the direct binding of 3′-UTR region of their target mRNAs. Recent studies have demonstrated that miRNAs are aberrantly expressed in the cardiovascular system under pathological conditions.Pyruvate dehydrogenase kinase 1 (PDK1) is a kinase which phosphorylates pyruvate dehydrogenase to inactivate it, leading to elevated anaerobic glycolysis and decreased cellular respiration. In the present study, we report that miR-138 expressions were significantly suppressed under long exposure to hypoxia. In addition, overexpression of miR-138 protects human cardiac cells against hypoxia. We observed miR-138 inhibits glycolysis but promotes mitochondrial respiration through directly targetting PDK1. Moreover, we demonstrate that hypoxia induces cardiac cell death through increased glycolysis and decreased mitochondrial respiration. Inhibition of glycolysis by either glycolysis inhibitor or knockdown glycolysis enzymes, Glucose transportor 1 (Glut1) or PDK1 contributes to cardiac cells’ survival. The cell sentivity to hypoxia was recovered when the PDK1 level was restored in miR-138 overexpressing cardiac cells. The present study leads to the intervention of novel therapeutic strategies against cardiac cells dysfunction during surgery or ischemia.
Omega-3 fatty acids and inflammatory processes: from molecules to man
Authors: Calder Philip C.
Published: September 2017

Inappropriate, excessive or uncontrolled inflammation contributes to a range of human diseases. Inflammation involves a multitude of cell types, chemical mediators and interactions. The present article will describe nutritional and metabolic aspects of omega-6 (n-6) and omega-3 (n-3) fatty acids and explain the roles of bioactive members of those fatty acid families in inflammatory processes. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are n-3 fatty acids found in oily fish and fish oil supplements. These fatty acids are capable of partly inhibiting many aspects of inflammation including leucocyte chemotaxis, adhesion molecule expression and leucocyte–endothelial adhesive interactions, production of eicosanoids like prostaglandins and leukotrienes from the n-6 fatty acid arachidonic acid and production of pro-inflammatory cytokines. In addition, EPA gives rise to eicosanoids that often have lower biological potency than those produced from arachidonic acid, and EPA and DHA give rise to anti-inflammatory and inflammation resolving mediators called resolvins, protectins and maresins. Mechanisms underlying the anti-inflammatory actions of EPA and DHA include altered cell membrane phospholipid fatty acid composition, disruption of lipid rafts, inhibition of activation of the pro-inflammatory transcription factor nuclear factor κB so reducing expression of inflammatory genes and activation of the anti-inflammatory transcription factor peroxisome proliferator-activated receptor γ. Animal experiments demonstrate benefit from EPA and DHA in a range of models of inflammatory conditions. Human trials demonstrate benefit of oral n-3 fatty acids in rheumatoid arthritis and in stabilizing advanced atherosclerotic plaques. Intravenous n-3 fatty acids may have benefits in critically ill patients through reduced inflammation. The anti-inflammatory and inflammation resolving actions of EPA, DHA and their derivatives are of clinical relevance.
Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR−/− mouse model of atherosclerosis
Authors: Thompson Dawn , Morrice Nicola , Grant Louise , Le Sommer  Samantha , Lees Emma K. , Mody Nimesh , Wilson Heather M. , Delibegovic Mirela
Published: September 2017

Cardiovascular disease (CVD) is the most prevalent cause of mortality among patients with type 1 or type 2 diabetes, due to accelerated atherosclerosis. Recent evidence suggests a strong link between atherosclerosis and insulin resistance, due to impaired insulin receptor (IR) signalling. Here, we demonstrate that inhibiting the activity of protein tyrosine phosphatase 1B (PTP1B), the major negative regulator of the IR prevents and reverses atherosclerotic plaque formation in an LDLR−/− mouse model of atherosclerosis. Acute (single dose) or chronic PTP1B inhibitor (trodusquemine) treatment of LDLR−/− mice decreased weight gain and adiposity, improved glucose homeostasis and attenuated atherosclerotic plaque formation. This was accompanied by a reduction in both, circulating total cholesterol and triglycerides, a decrease in aortic monocyte chemoattractant protein-1 (MCP-1) expression levels and hyperphosphorylation of aortic Akt/PKB and AMPKα. Our findings are the first to demonstrate that PTP1B inhibitors could be used in prevention and reversal of atherosclerosis development and reduction in CVD risk.
Optimal sizing method of vanadium redox flow battery to provide load frequency control in power systems with intermittent renewable generation
Authors: Martínez Maximiliano , Molina Marcelo Gustavo , Mercado Pedro Enrique
Published: September 2017

This study proposes a novel methodology for optimal sizing of a vanadium redox flow battery (VRFB) aiming at providing the load frequency control (LFC) of power system (PSs) with renewable generation, such as wind generation. This methodology utilises a new optimisation problem, where the optimal size of the VRFB is an endogenous result from the model of optimisation problem. To resolve the new optimisation problem, a hybrid optimisation model (HOM) is employed in order to calculate the optimal investment for the VRFB (optimal size) while taking into account both its impact on the PS costs and on the quality of the system frequency. Through stochastic optimisation, the HOM allows computing the variable operating costs and VRFB investment costs, considering the uncertainties associated to the PS. This stochastic optimisation utilises a new quasi‐stationary simulations of the PS operation, which demands lower computing effort. To this aim, this study proposes a novel modelling approach of both the VRFB and the PS operation. Moreover, statistical indexes are proposed as new factor used in sizing the LFC operating reserve. The results show that the developed methodology allows evaluating with precision the stochastic characteristics of the PS.
Chance‐constrained programming for day‐ahead scheduling of variable wind power amongst conventional generation mix and energy storage
Authors: Tan Wen‐Shan , Shaaban Mohamed , Abdullah Md Pauzi
Published: September 2017

This study presents a day‐ahead scheduling of a generation portfolio incorporating large shares of intermittent wind generation. The scheduling utilises the cycling of conventional generation as well as the dispatch of energy storage (ES) to mitigate the impact of net load ramps. Inherent system flexibility, expressed as a chance constraint, is quantified in terms of ramping capability and operating reserves of conventional generation and ES. The flexibility chance constraint is then factorised into a set of linear deterministic inequalities, to preserve the mixed‐integer linear programming structure of the resulting problem. Numerical simulations are performed and results are analysed for IEEE 24‐bus and 118‐bus systems. Test results show that implementation of ES improves the flexibility of the system, in terms of alleviation of the cycling of thermal generation as well as wind generation curtailment.
Feature extraction of power transformer vibration signals based on empirical wavelet transform and multiscale entropy
Authors: Zhao Miaoying , Xu Gang
Published: September 2017

To achieve an effective feature extraction for power transformer vibration signals, the authors propose a method for signal feature extraction based on empirical wavelet transform (EWT) and multiscale entropy (MSE). First, transformer vibration signals are decomposed into several empirical wavelet functions (EWFs) with the method of EWT. Then, the frequency characteristics of signals are demonstrated in the time‐frequency representation by applying a Hilbert transform to each EWF component. Finally, in order to quantify the extracted features, the MSEs of components being highly correlated with the original signals are calculated to construct the eigenvectors of transformer vibration signals. Several experiments are presented showing the effectiveness of this method compared with the classic empirical mode decomposition method.
Parametric study on kink instabilities of twisted magnetic flux ropes in the solar atmosphere
Authors: Mei Z. X. , Keppens R. , Roussev I. I. , Lin J.
Published: September 2017

Aims. Twisted magnetic flux ropes (MFRs) in the solar atmosphere have been researched extensively because of their close connection to many solar eruptive phenomena, such as flares, filaments, and coronal mass ejections (CMEs). In this work, we performed a set of 3D isothermal magnetohydrodynamic (MHD) numerical simulations, which use analytical twisted MFR models and study dynamical processes parametrically inside and around current-carrying twisted loops. We aim to generalize earlier findings by applying finite plasma β conditions.

Methods. Inside the MFR, approximate internal equilibrium is obtained by pressure from gas and toroidal magnetic fields to maintain balance with the poloidal magnetic field. We selected parameter values to isolate best either internal or external kink instability before studying complex evolutions with mixed characteristics. We studied kink instabilities and magnetic reconnection in MFRs with low and high twists.

Results. The curvature of MFRs is responsible for a tire tube force due to its internal plasma pressure, which tends to expand the MFR. The curvature effect of toroidal field inside the MFR leads to a downward movement toward the photosphere. We obtain an approximate internal equilibrium using the opposing characteristics of these two forces. A typical external kink instability totally dominates the evolution of MFR with infinite twist turns. Because of line-tied conditions and the curvature, the central MFR region loses its external equilibrium and erupts outward. We emphasize the possible role of two different kink instabilities during the MFR evolution: internal and external kink. The external kink is due to the violation of the Kruskal-Shafranov condition, while the internal kink requires a safety factor q = 1 surface inside the MFR. We show that in mixed scenarios, where both instabilities compete, complex evolutions occur owing to reconnections around and within the MFR. The S-shaped structures in current distributions appear naturally without invoking flux emergence. Magnetic reconfigurations common to eruptive MFRs and flare loop systems are found in our simulations.
Local Swift-BAT active galactic nuclei prefer circumnuclear star formation
Authors: Lutz D. , Shimizu T. , Davies R. I. , Herrera-Camus R. , Sturm E. , Tacconi L. J. , Veilleux S.
Published: September 2017

We use Herschel data to analyze the size of the far-infrared 70 μm emission for z < 0.06 local samples of 277 hosts of Swift-BAT selected active galactic nuclei (AGN), and 515 comparison galaxies that are not detected by BAT. For modest far-infrared luminosities 8.5 <log  (LFIR [L⊙]) < 10.5, we find large scatter of half light radii Re,70 for both populations, but a typical Re,70≲ 1 kpc for the BAT hosts that is only half that of comparison galaxies of same far-infrared luminosity. The result mostly reflects a more compact distribution of star formation (and hence gas) in the AGN hosts, but compact AGN heated dust may contribute in some extremely AGN dominated systems. Our findings are in support of an AGN-host coevolution where accretion onto the central black hole and star formation are fed from the same gas reservoir, with more efficient black hole feeding if that reservoir is more concentrated. The significant scatter in the far-infrared sizes emphasizes that we are mostly probing spatial scales much larger than those of actual accretion, and that rapid accretion variations can smear the distinction between the AGN and comparison categories. Large samples are hence needed to detect structural differences that favor feeding of the black hole. No size difference between AGN host and comparison galaxies is observed at higher far-infrared luminosities log(LFIR [L⊙]) > 10.5 (star formation rates ≳6 M⊙ yr-1), possibly because these are typically reached in more compact regions.
No Difference in Functional Outcomes after Total Knee Arthroplasty with or without Pinless Navigation
Authors: Chen Jerry , Chong Hwei , Pang Hee , Tay Darren , Chia Shi-Lu , Lo Ngai , Yeo Seng , Zhu Meng
Published: September 2017

This study aims to investigate the functional outcomes of pinless navigation (BrainLAB VectorVision Knee 2.5 navigation system; Munich, Germany) as an intraoperative alignment guide in total knee arthroplasty (TKA). A prospective, 24-month follow-up study of 100 patients who were scheduled and randomized into two groups, the pinless navigation and conventional surgery, was conducted. All TKAs were performed with the surgical aim of achieving neutral coronal alignment with the 180-degree mechanical axis. The outcomes measured in this study were Oxford Knee Score (OKS), Knee Society Score (KSS), Short Form-36 (SF-36), and range of motion (ROM). At 24-month postoperatively, four and two patients were lost to follow-up from the pinless navigation group and conventional group, respectively. There were no significant differences in absolute scores of the OKS, KSS, and ROM, as well as changes from preoperative baseline, between pinless navigation and conventional groups at both 6 and 24 months postoperatively. Pinless navigation results in comparable functional outcomes as conventional TKA at 6 and 24 months postoperatively.
Multiple endokrine Neoplasie
Authors: Schaaf Ludwig , Raue Friedhelm
Published: September 2017

Multiple endocrine neoplasia type 1 and 2 are hereditary cancer syndromes. They are characterized by the occurrence of many benign and malignant tumor types, in MEN1 parathyroid tumors, pituitary tumors, and pancreas tumors, in MEN2 medullary thyroid carcinoma, pheochromocytoma, and parathyroid tumors. The autosomal dominant inherited tumor syndromes are caused by mutations in the MEN1 gene, a tumor suppressor gene, and mutations in the RET gene, an activated oncogene, in MEN2. The clinical expression of the different tumors can vary within and between families, with a good genotype-phenotype correlation in MEN2. Early diagnosis and therapy is possible by using biochemical and imaging screening in the families. Early thyroidectomy in young patients with MEN2 results in a high cure rate of MTC.
Prioritäten deutscher Onkologen. Auswertung der „Klug entscheiden“-Umfrage der Deutschen Gesellschaft für Hämatologie und Medizinische Onkologie (DGHO)
Authors: Krause Stefan , Oldenburg Michael , Hallek Michael , Neubauer Andreas
Published: September 2017

Hintergrund Die Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie (DGHO) hatte im Rahmen der „Klug entscheiden“-Initiative ihre Mitglieder zur Über- und Unterversorgung befragt. Aus der großen Menge an Antworten ergab sich ein überraschend deutliches Meinungsbild, das für die hier vorliegende Darstellung quantitativ ausgewertet wurde.

Methodik Die Bewertung der vorformulierten Empfehlungen wird mittels beschreibender Statistik dargestellt. Die Freitextantworten wurden in einem iterativen Verfahren in 3 Ebenen nach der medizinischen Aussage und ergänzend nach der allgemeinen Zielrichtung kategorisiert.

Ergebnisse 492 DGHO-Mitglieder schlossen die Online-Umfrage in der kurzen Frist von 14 Tagen vollständig ab. Die vorgeschlagenen Empfehlungen zur Vermeidung von Überversorgung fanden eine breite inhaltliche Zustimmung (77 % bis 88 % der Teilnehmer). In den 1598 Freitextantworten wurde der Verzicht auf unnötigen Einsatz von Ressourcen und unnötige Belastung von Patienten in Übereinstimmung mit unseren Empfehlungen gefordert. Eine mögliche Unterversorgung wurde weniger auf dem Gebiet teurer medizinischer Maßnahmen gesehen (17 % der Antworten) als vielmehr bei weichen Faktoren: „sprechende“ Medizin, individuelle Therapieführung, Supportivtherapie und Palliativtherapie sowie soziale Ressourcen (62 %).

Schlussfolgerung Aus den Antworten ergab sich ein deutliches Votum für ein Mehr an sprechender Medizin in der onkologischen Versorgung. Jeder beteiligte Arzt kann hierzu beitragen. Strukturelle Verbesserungen in der Vergütung und Weiterbildung sind jedoch wünschenswert.
100 Jahre Hautklinik an der Georg-August-Universität in Göttingen: Die Moulagensammlung
Authors: Ude-Koeller S. , Fuchs T.
Published: September 2017

Moulagen wurden über viele Jahrzehnte als Lehrmittel verwendet und schienen im dermatologischen Unterricht bis in die 50er-Jahre unverzichtbar. Sie wurden dennoch von der Farbfotografie abgelöst. Mit diesen historischen Aspekten wird ein Bogen geschlagen zu aktuellen Entwicklungen, d. h. zu Perspektiven der interdisziplinären Moulagen-Forschung, zu Problemen bzw. Herausforderungen ihrer öffentlichen Präsentation, zur erneuten Integration der Moulagen in die dermatologische Lehre. Grundlage hierfür ist die seit 1917 unter dem ersten dermatologischen Göttinger Lehrstuhlinhaber Prof. Dr. Rudolf Erhard Riecke (1869 – 1939) in Göttingen angelegte Moulagen-Sammlung. In dem Zusammenhang erfolgten erstmalig biografische Nachforschungen zu dem in der Klinik tätigen Mouleur August Leonhardt. Dabei bestätigte sich die Bedeutung dieser Berufsgruppe als maßgebliche Sammlungsakteure.
Schwangerschaft bei Niereninsuffizienz
Authors: Kurschat Christine , Benzing Thomas
Published: September 2017

Eine reduzierte Nierenfunktion beeinflusst die Fertilität und geht in der Schwangerschaft mit einem erhöhten Risiko für Mutter und Kind
einher. Dieses Risiko hängt von der Schwere der Nierenfunktionseinschränkung ab. Frauen mit geringer Niereninsuffizienz und normalem
Blutdruck haben meist kein erhöhtes Risiko. Frauen mit schwerer Niereninsuffizienz haben in bis zu 92 % der Fälle Komplikationen, daher
sollte in diesem Fall mit der Schwangerschaft gewartet werden, bis eine Nierentransplantation erfolgreich durchgeführt wurde, denn diese
führt zu einer deutlichen Reduktion der Komplikationen. Wenn eine nierentransplantierte Patientin einen Schwangerschaftswunsch äußert,
sollte die medikamentöse Therapie vor dem Eintreten der Schwangerschaft bereits umgestellt werden. Dies betrifft i. d. R. immunsuppressive
und antihypertensive Medikamente. Durch eine Schwangerschaft können sich vorbestehende Glomerulonephritiden verschlechtern, insbesondere die
Lupusnephritis und die Nierenbeteiligung bei systemischer Sklerose. Harnwegsinfekte müssen in der Schwangerschaft differenziert antibiotisch
therapiert werden.
Definition und Therapieoptionen
Authors: Breu Christian
Published: September 2017

Dieser Artikel ist der Beginn einer Reihe über den Themenbereich Apherese in der Dialyse aktuell („Apherese A–Z“). Er definiert, was
unter dem Begriff „Apherese“ zusammengefasst wird und welche Therapieoptionen möglich sind.
Quantitatives EMG und mehr
Authors: Schulte-Mattler Wilhelm
Published: September 2017

Es war zunächst geplant, das vorliegende Themenheft mit „quantitatives EMG“ zu überschreiben. Den Lesern der „Klinische Neurophysiologie“ wird klar sein, dass mit diesem Thema jedenfalls dann kein ganzes Heft zu füllen ist, wenn man meint: „quantitatives EMG, das ist doch Sammeln und Ausmessen von Potenzialen von zwanzig verschiedenen motorischen Einheiten“. Ein Ziel dieses Heftes ist es dazu beizutragen, dass dieser Satz nicht mehr so oft zu hören oder zu lesen ist.
Kerr microscopy study of thermal and athermal training effects in a Co/CoO exchange bias system
Authors: Hussain Zaineb , Raghavendra Reddy V.
Published: September 2017

The present work reports the magnetic domain evolution during the magnetization reversal and the training effect in a polycrystalline Co/CoO exchange bias system. Co/CoO bilayers with different cobalt (Co) layer thicknesses are being studied. The measurements are carried out using the Kerr microscopy at different temperatures (≥ 80 K) after the field-cooling across the Néel temperature of the antiferromagnetic (AFM) CoO layer. It is observed that with the increasing ferromagnetic (FM) Co layer thickness, the exchange bias reduces and the training effect becomes weaker. Analysis of the temperature variation of the exchange bias field indicates an increasing disorder at the FM-AFM interface with the decreasing FM thickness. Two different training effects, viz., athermal and thermal mechanisms, are observed depending on the thickness of the FM layer. For the lower FM thickness an athermal training effect is observed, whereas for the thicker FM layer thermal training effect is dominated. The domain structure of FM layers drastically changes during the athermal training effect with the cycling and domain size significantly decreasing during the magnetization reversal process below blocking temperature (TB), whereas in the thermal training mechanism no significant changes are found in the magnetic domain evolution throughout the temperature range with cycling. These results are expected to provide key inputs to various theoretical models that are being used to study the exchange bias phenomena in the recent literature.
Numerical study of two-dimensional cylindrical underwater explosion by a modified method of characteristics
Authors: Yang Chenchen , Li Xiaojie , Zhang Chengjiao
Published: September 2017

A modified method of characteristics (mMOC) is introduced for solution of 2D axisymmetric supersonic flow, as well as its application to simulation of a cylindrical underwater explosion, which is a typical non-homentropic flow problem. The modifications include a family of compatibility equations which contains entropy term in streamline direction, an improved backward scheme with second-order accuracy, a modified forward scheme that uses adaptive technique, which in total make this mMOC be appropriate for a branch fluid dynamics with isentropic or non-isentropic flows. The numerical results show good agreement between the mMOC and experiments. It is established that this mMOC yields shock location, shock peak pressure, and gas-water interface location with an acceptable accuracy. Compared with an explicit dynamics program AUTODYN, which needs to select an appropriate artificial viscosity to handle shock discontinuity properly, the mMOC typically requires far less computer time with the same accuracy in the calculation of the underwater shock wave. Besides, the formation of a secondary shock is well revealed in the pressure nephogram, which suggests the mMOC is able to capture small variation in flow field. In addition, this mMOC can clearly display the domain of dependence in characteristic net, which makes it possible to quantitatively describe the connection between near field shock and detonation products expansion.
Controllable photoresponse behavior in a single InAs nanowire phototransistor
Authors: Li Bang , Yan Xin , Zhang Xia , Luo Yanbin , Lu Qichao , Ren Xiaomin
Published: September 2017

We demonstrate a single InAs nanowire phototransistor with controllable photoresponse behavior. The device is based on a top-gated nanowire field effect transistor with an electron mobility of 5790 cm2 V−1 s−1. In the absence of gate voltage, negative and positive photoresponses are observed under low and high illumination, respectively. By applying a relatively high negative/positive gate voltage, pure positive/negative photoresponse is obtained, respectively. The controllable photoresponse is attributed to a gate-voltage-induced barrier height modulation between the trap state energy level in the photogating layer and the conduction band of nanowire. The device is promising for optoelectronic applications.
The Gibbs free energy of homogeneous nucleation: From atomistic nuclei to the planar limit
Authors: Cheng Bingqing , Tribello Gareth A. , Ceriotti Michele
Published: September 2017

In this paper we discuss how the information contained in atomistic simulations of homogeneous nucleation should be used when fitting the parameters in macroscopic nucleation models. We show how the number of solid and liquid atoms in such simulations can be determined unambiguously by using a Gibbs dividing surface and how the free energy as a function of the number of solid atoms in the nucleus can thus be extracted. We then show that the parameters (the chemical potential, the interfacial free energy, and a Tolman correction) of a model based on classical nucleation theory can be fitted using the information contained in these free-energy profiles but that the parameters in such models are highly correlated. This correlation is unfortunate as it ensures that small errors in the computed free energy surface can give rise to large errors in the extrapolated properties of the fitted model. To resolve this problem we thus propose a method for fitting macroscopic nucleation models that uses simulations of planar interfaces and simulations of three-dimensional nuclei in tandem. We show that when the chemical potentials and the interface energy are pinned to their planar-interface values, more precise estimates for the Tolman length are obtained. Extrapolating the free energy profile obtained from small simulation boxes to larger nuclei is thus more reliable.
Phase segregation in MgxZn1–xO probed by optical absorption and photoluminescence at high pressure
Authors: Marín-Borrás V. , Ruiz-Fuertes J. , Segura A. , Muñoz-Sanjosé V.
Published: September 2017

The appearance of segregated wurtzite MgxZn1–xO with low Mg content in thin films with x > 0.3 affected by phase separation cannot be reliably probed with crystallographic techniques owing to its embedded nanocrystalline configuration. Here, we show a high-pressure approach which exploits the distinctive behaviors under pressure of wurtzite MgxZn1–xO thin films with different Mg contents to unveil phase segregation for x > 0.3. By using ambient conditions, photoluminescence (PL), and with optical absorption and PL under high pressure for x = 0.3, we show that the appearance of a segregated wurtzite phase with a magnesium content of x ∼ 0.1 is inherent to the wurtzite and rock-salt phase separation. We also show that the presence of segregated wurtzite phase in oversaturated thin films phase is responsible for the low-energy absorption tail observed above x = 0.3 in our MgxZn1–xO thin films. Our study has also allowed us to extend the concentration dependence of the pressure coefficient of the band gap from the previous limit of x = 0.13 to x ≈ 0.3 obtaining dEg/dP = 29 meV/GPa for wurtzite with x ≈ 0.3 and 25 meV/GPa for the segregated x ≈ 0.09 wurtzite phase.
An efficient optimization method to improve the measuring accuracy of oxygen saturation by using triangular wave optical signal
Authors: Li Gang , Yu Yue , Zhang Cui , Lin Ling
Published: September 2017

The oxygen saturation is one of the important parameters to evaluate human health. This paper presents an efficient optimization method that can improve the accuracy of oxygen saturation measurement, which employs an optical frequency division triangular wave signal as the excitation signal to obtain dynamic spectrum and calculate oxygen saturation. In comparison to the traditional method measured RMSE (root mean square error) of SpO2 which is 0.1705, this proposed method significantly reduced the measured RMSE which is 0.0965. It is notable that the accuracy of oxygen saturation measurement has been improved significantly. The method can simplify the circuit and bring down the demand of elements. Furthermore, it has a great reference value on improving the signal to noise ratio of other physiological signals.
A miniature Hopkinson experiment device based on multistage reluctance coil electromagnetic launch
Authors: Huang Wenkai , Huan Shi , Xiao Ying
Published: September 2017

A set of seven-stage reluctance miniaturized Hopkinson bar electromagnetic launcher has been developed in this paper. With the characteristics of high precision, small size, and little noise pollution, the device complies with the requirements of miniaturized Hopkinson bar for high strain rate. The launcher is a seven-stage accelerating device up to 65.5 m/s. A high performance microcontroller is used to control accurately the discharge of capacitor sets, by means of which the outlet velocity of the projectile can be controlled within a certain velocity range.
Determination of eddy current response with magnetic measurements
Authors: Jiang Y. Z. , Tan Y. , Gao Z. , Nakamura K. , Liu W. B. , Wang S. Z. , Zhong H. , Wang B. B.
Published: September 2017

Accurate mutual inductances between magnetic diagnostics and poloidal field coils are an essential requirement for determining the poloidal flux for plasma equilibrium reconstruction. The mutual inductance calibration of the flux loops and magnetic probes requires time-varying coil currents, which also simultaneously drive eddy currents in electrically conducting structures. The eddy current-induced field appearing in the magnetic measurements can substantially increase the calibration error in the model if the eddy currents are neglected. In this paper, an expression of the magnetic diagnostic response to the coil currents is used to calibrate the mutual inductances, estimate the conductor time constant, and predict the eddy currents response. It is found that the eddy current effects in magnetic signals can be well-explained by the eddy current response determination. A set of experiments using a specially shaped saddle coil diagnostic are conducted to measure the SUNIST-like eddy current response and to examine the accuracy of this method. In shots that include plasmas, this approach can more accurately determine the plasma-related response in the magnetic signals by eliminating the field due to the eddy currents produced by the external field.