bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of perceived nursing delivery type, errors in handover, and missed nursing care on the nursing performance of hospital nurses
Authors: Ko Yukyung , Lee Eunkyo , Lee Youngjin
Published: February 2024

Background
In clinical practice, the prioritization of task-oriented care over patient-centered care, due to nursing staff shortages, highlights the need for an effective handover process to prevent adverse patient outcomes. This study aims to assess the current state of the nursing delivery system, focusing on handover errors, missed nursing activities, and their effect on nursing performance—including turnover intention.
Methods
This study performed a survey involving 300 clinical nurses. The survey, conducted using both online and paper questionnaires, comprised a structured self-reporting tool covering various aspects, including nursing delivery system type, turnover intention, and nursing performance. SPSS 25.0 software was used for the analysis.
Results
Factors influencing turnover intention included high labor intensity, low wages, and workplace relationships. Missed nursing activities negatively affected performance, while higher education and advanced positions demonstrated positive effects. Handover errors emerged as a significant factor impacting turnover intention, with module nursing exerting the most significant influence.
Conclusions
Based on the findings, this study recommends nursing management interventions to address missed activities and enhance overall performance. The findings provide valuable insights for managers to identify causes of poor performance and nurses’ turnover, and implement targeted strategies to lay the groundwork for future research on the intricate relationship between the type of nursing delivery system and nursing performance. This study contributes to the ongoing discourse on optimizing nursing care in the face of staffing challenges, emphasizes the critical role of effective handovers, and suggests practical avenues for improvement in nursing service quality.
Non-traumatic gallbladder hemorrhage with shock in Asia；A case report
Authors: Tu Chung Yang
Published: February 2024

Background
Gallbladder hemorrhage, rared and caused by trauma, iatrogenic factors, or underlying conditions like liver/kidney dysfunction or cancer, presents with symptoms such as right upper abdominal pain and fever. In severe cases, blood from the gallbladder may enter the gastrointestinal tract, causing melena or hematemesis. Blood clots may also cause blockage and inflammation, requiring surgical intervention for effective management. Failure to promptly address this can lead to life-threatening hemorrhagic shock. Diagnosing rare diseases in the emergency room is challenging and crucial. Delayed diagnosis may lead to life-threatening conditions, especially hemorrhagic shock. Ultrasound is vital for diagnosing this disease.
Case presentation
A 64-year-old female presented with three days of epigastric pain and nausea, denying trauma, fever, respiratory or chest symptoms, but with unstable vital signs. Blood tests showed no abnormalities, while an Ultrasound revealed a distended gallbladder without stones. Following cholecystectomy, the diagnosis confirmed acute hemorrhagic cholecystitis, attributed to chronic cholecystitis. This case highlights the pivotal role of ultrasound in diagnosing hemorrhagic cholecystitis.
Conclusion
Gallbladder hematoma, a rare condition with vague symptoms, poses diagnostic challenges, often linked to trauma, tumors, anticoagulant use, or liver/renal disease. Common symptoms include right upper quadrant pain, tenderness, nausea, and vomiting, initially resembling cholecystitis. Persistent bleeding may result in dark or bloody stools. While laboratory tests may reveal abnormalities, their sensitivity is limited. Diagnosis is complex, and delayed recognition in the emergency department can lead to severe shock and increased mortality. The literature review emphasizes the association with liver/kidney dysfunction and anticoagulant use, presenting symptoms akin to gallbladder inflammation and occasional gastrointestinal bleeding. Ultrasound is pivotal for diagnosis, showcasing distinctive features like uneven echoes and localized wall thickening. Treatment approaches vary, with some cases opting for deferred surgical intervention after conservative treatment, though surgery remains a common outcome. In summary, non-traumatic gallbladder hematoma is primarily linked to risk factors like liver/kidney diseases and chronic anticoagulant use. Gallbladder inflammation and gastrointestinal bleeding symptoms coexist, underscoring the crucial role of timely ultrasound diagnosis. This study establishes early detection and diagnosis protocols for future reference in emergency room settings.
Endometrial Gene Expression Profiles of Infertile Women with Thin Versus Normal Endometrial Thickness on The Day of Oocyte Retrieval: A cross-sectional study
Authors: Humart Pavarit , Tungprasertpol Kittima , Klaymook Supatra , Sukthanarak Chonlaphat , Petyim Somsin
Published: February 2024

To compare the expression of the endometrial FUT4, CDH2, SOX9, LGR5, POU5F1, PDGFRB, SUSD2, and MCAM genes, which are associated with different endometrial locations, between the thin endometrium and normal endometrial thickness. Between May 2022 and February 2023, we collected tissue samples from 20 infertile women who underwent controlled ovarian stimulation. The samples consisted of 10 thin endometrium (< 7 mm) samples and 10 normal endometrial thickness (≥ 7 mm) samples collected on the day of oocyte retrieval. The expression levels of the endometrial genes were analyzed using quantitative real-time polymerase chain reaction. There were no significant differences in the expression levels of FUT4, CDH2, SOX9, LGR5, POU5F1, PDGFRB, SUSD2, and MCAM genes between both groups (p = 0.912, p = 0.529, p = 0.481, p = 0.123, p = 0.796, p = 0.247, p = 0.063, p = 0.853 respectively). There were also no significant differences in gene expression profiles between the groups according to the history of endometrial surgery, estradiol level, type of gonadotropin, and drug used for oocyte triggering. The endometrial gene expression profiles associated with different endometrial locations on the day of oocyte retrieval were not different between thin and normal endometrial thickness groups.
Validation of a New 2-Channel Portable Sleep Staging Device: Quantitative Analysis of Electroencephalography, Electromyography, and Electrooculography
Authors: Ogino Hiroyuki , So Mirai , Hashimoto Sora , Suenaga Kazue , Endo Takuro , Nishino Seiji , Mimura Masaru
Published: February 2024

Sleep scores obtained using a 2-channel portable telemetry polysomnographic (PSG) system, named SleepGraph, demonstrated an almost perfect correlation when compared to standard laboratory PSG. The components of sleep-stage dependent electroencephalographic (EEG), electromyographic (EMG), and electrooculographic (EOG) results were strikingly consistent between the SleepGraph and the standard PSG. The distinct EEG components were elucidated using the EEG power spectrum. What sets the SleepGraph apart is its innovative approach to EMG and EOG derivation from the lower eyelid to the opposite chin. This unique configuration not only reduces the number of required facial electrodes but also enhances the sleep stage specificity of both EMG and EOG measurements. By using digital band-pass filters, the EMG and EOG records were distinctly separated. The specificity of the EEG power in the δ, α, spindle, and β ranges, along with the EMG integral and the EOG variance, proves to be particularly strong, suggesting their potential as reliable parameters for the development of artificial intelligence-based sleep diagnostic algorithms.
A novel method for evaluating shale gas preservation conditions in an area on a regional scale
Authors: Liu Yuzuo , Shi Wanzhong , Feng Qian , Yuan Kun , Wang Ren , Zhang Xiaoming , Bai luheng
Published: February 2024

The Youjiang Basin is the main area of the Middle Devonian shale gas resources in southern China, with complex geological conditions, diverse stratigraphic structures, low level of exploration and limited hydrocarbon geological data. In this study, a method is proposed for evaluating the regional shale gas preservation conditions, by which it is easy to obtain information (using available data from regional geological maps) and to process data (processed by computer software). This method was applied to the evaluation of the preservation conditions of the Middle Devonian shale gas in the Youjiang Basin. Information extracted from geologic maps includes exposed stratum, magmatic rock distribution, stratigraphic occurrence and surface fracture distribution. Evaluation criteria for three indexes (stratigraphy index, dip angle index and fracture index) were established to classify the preservation conditions into five types from good to bad. Based on the calculated values of comprehensive index (CI), the comprehensive evaluation each area: 11621.23 km2 for CI of 0.7 - 1.0, 37162.67 km2 for CI of 0.5 - 0.7, 57784.43 km2 for CI of 0.3 - 0.5, 69303.77 km2 for CI of 0.1 - 0.3, and 69303.77 km2 for CI of 0.0 - 0.1, accounting for 3.19%, 10.19%, 15.84%, 18.99% and 51.80% of the whole area, respectively. These results are highly consistent with the actual exploration discoveries, showing that in the northern and central parts of the Guizhong Basin, the southern part of the Xidamingshan Uplift, and the northern part of the Qiannan Basin, there are large areas with good shale gas preservation conditions.
Association between serum Calcium and 28-day mortality in Pediatric Pneumonia: Insights from a PICU Retrospective Cohort
Authors: Zhao Jinling , Liu Meihong , Yu Dan , Zhang Ying-ying
Published: February 2024

This study investigates the impact of serum calcium levels on the 28-day hospital mortality rate in children with pneumonia, a topic not extensively explored previously. Analyzing data from 414 patients at Zhejiang University Medical College's Children's Hospital (2010–2019), the study categorized patients by serum calcium levels for 28-day mortality monitoring. Results show that each 1mmol/dL increase in serum calcium reduced 28-day mortality risk by 26% (HR: 0.74, 95% CI: 0.65–0.85). Patients with higher serum calcium levels had a 63% lower mortality rate compared to those with lower levels (HR: 0.37, 95% CI: 0.16–0.85). These findings, consistent across various subgroups, highlight serum calcium as a significant prognostic marker for pediatric pneumonia, influencing clinical decisions and pointing to the need for further research in this area.
The Influence of Community Physical Exercise on the Subjective Well-Being of Older Adults: the Mediating Role of Social Capital and the Moderating Role of Intergenerational Support
Authors: Lin Yuanzheng , Zhang Peng , Ma Xiujie , Luo Qingyuan
Published: February 2024

Background Against the backdrop of increasing global population aging, fostering well-being among older adults becomes paramount. This study explored the effects of community physical exercise on the subjective well-being of older adults, as well as the mediating role of social capital and the moderating role of intergenerational support, to help promote healthy aging. Methods This study was conducted in selected urban living communities in Sichuan, China. A total of 319 older adults aged 60 years and older completed this survey by distributing a questionnaire, including the Physical Exercise Level Scale, the Social Capital Scale, the Intergenerational Support Scale, and the Subjective Well-Being Scale, to older adults in the community who participated in physical exercise. The structural equation modeling was tested for mediation and moderating effects using SPSS and PROCESS plug-ins. Results The results of the study showed that older adults' participation in community physical exercise can effectively promote their subjective well-being and also indirectly improve their subjective well-being by increasing social capital. In addition, intergenerational support provided by children moderated the effects of community physical exercise and social capital on subjective well-being, suggesting that children's support can significantly influence the subjective well-being of older adults in Chinese family social relationships. Conclusion Engaging in community physical exercise significantly promoted older adults' subjective well-being, mediated by strengthened social capital. Notably, children's support amplified these positive effects, highlighting the crucial role of family in elder well-being.
Comparison of digital and conventional impression techniques: Restoration rework rate
Authors: Xu Zhiqiang , Zheng Liyuan , Tao Xian , Jin Di , Wu Qianju
Published: February 2024

Purpose
Digital impressions are gradually replacing traditional impressions. The accuracy of both digital and traditional impressions may affect the success of fixed restorations in clinics. Currently, there are only few in vivo studies on the clinical effectiveness of digital impressions. This retrospective study aimed to compare the rework rate of fixed crowns fabricated from digital and traditional impressions to test whether digital impressions are really suitable for fixed restorations in clinics.
Materials and Methods
The data of present study was collected from the digital denture management system at the Stomatological Hospital of Xiamen Medical College between November 2019 and October 2022. All laboratory prescriptions of all-zirconia crowns over the past 3 years were grouped according to the impression type (i.e., digital or traditional). The rework rates of all-zirconia single crowns, 2-unit crowns, 3-unit crowns, and multi-unit crowns (≥ 4 units) were analyzed using the chi-square test. The rework prescriptions were divided into three groups according to the reasons for failure, including abnormal occlusion (Group 1), incompatible edges (Group 2), and abnormal positioning (Group 3). The rework rate was compared among groups using the chi-square test.
Results
The rework rates of the traditional and digital impressions were 1.93% and 2.31%, respectively. The rework rate was higher for traditional impressions than digital impressions for both single and 2-unit crowns with no significant differences. For the multi-unit restorations, the rework rate of traditional impressions was lower than digital impressions with no significant differences. Furthermore, the rework rate of digital impressions gradually increased with the increasing number of teeth (P < 0.05). In contrast, there were no statistical significant differences for conventional impressions. With respect to different causes of rework, the rates due to abnormal occlusion or incompatible edges existed no significant differences between the traditional and digital impressions, while the rate in the digital impressions was lower than that traditional groups due to the inability to position (P < 0.05). When applying the same impression method, the most common cause of rework was incompatible edges (P < 0.05).
Conclusion
Based on our hospital data from the past 3 years, intraoral scanning and traditional impressions can be used effectively in clinics. Our results highlight the advantages and disadvantages of the digital impression technique, as well as emphasize its future applications.
Long non-coding RNA HOXA-AS3 promotes glioma progression via miR-542-5p/HOXA1 axis
Authors: Cui Lianxu , He Ruiyu , Li Haowen , Peng Siwei , Zhang Meiru , Ma Zhanchuan , Li Zaiyu
Published: February 2024

Aims: Gliomas is one of the brain cancers belongs to the central nervous system(CNS) tumor. We previously showed that administration of natural product pristimerin significantly impaired the U373 cell progression by disturbing the miR-542-5p expression. But the upstream genes of miR-542-5p in glioma is still ill-defined.
Methods: We used the RNA 22 v2 to predict the binding sites for lncRNAs and miRNAs. TCGA database was used to analyze the expression of HOXA-AS3, HOXA1 and WNT5A in glioma tissues. Survival curve of HOXA-AS3 in LGG patients was plotted. Glioma cell U373 and U251 were used to transfect with the siRNA to access the apoptosis rate and migration of cells. And tumor model was constructed to access the function of the HOXA-AS3 in vivo.
Results: Our results showed the increased HOXA-AS3 and HOXA1 expression in glioma tissues. Cell growth/migration could be effectively suppressed by silencing HOXA-AS3or/and hsa-miR-542-5p in U373 cell, while cell apoptosis rate enhanced, which could be reserved by amplifying hsa-miR-542-5p expression. In addition, we found the decreased HOXA1 and WNT5A expression in HOXA-AS3silenced condition. In vivo experiments showed that silencing HOXA-AS3and hsa-miR-542-5p suppressed U373 tumor growth by inhibiting arginase-1 expression in tumor-associated macrophages. High level of HOXA-AS3, HOXA1, and WNT5A in tumor cell were associated with poor overall survival in patients with low-grade glioma, higher expression of which in tumor-infiltrating lymphocytes also correlated with worse patients’ outcome.
Conclusions: Our results showed that HOXA-AS3 might promote glioma progression via regulating hsa-miR-542-5p/HOXA1and WNT5A.
Characteristic but often missed MRI images of C5 brachial plexus paralysis caused by minor external forces
Authors: Taguchi Hiroyuki , Moriya Kozo
Published: February 2024

Shoulder joint elevation disorder caused by C5 brachial plexus injury can be diagnosed by characteristic images of MRI.
In the case of C5 root disorder, asymmetrical T2 hyperintensity findings around the C5 root on MRI may be decisive for confirming the diagnosis of brachial plexus injury.
Shoulder elevation disorder is a common disease, but its cause can be difficult to identify.
In Japan, shoulder abduction injury caused by a minor external force is often diagnosed as unexplained or due to rotator cuff injury.
A minor external force is such a force that occurs when the patient almost slips off the roof and hangs on an iron bar with one hand, or when the patient's hand is pulled by a friend.
However, I have experienced that many of them are due to C5 nerve root palsy.
In that case, after a few months, muscle strength suddenly recovers, and shoulder abduction is possible.
It is meaningful for both the patient and the doctor to be able to confirm the diagnosis in that they can observe the progress with hope.
Conversion of sweet whey to bioethanol: a bioremediation alternative for dairy industry
Authors: Conde Laura
Published: February 2024

In many countries, whey from the dairy industry is an abundant waste that generates an important environmental impact. Alternative processes to use the whey and minimize the environmental impact are needed. This work considered six formulations with different ammonium sulfate and L-phenylalanine (L-Phe) concentrations to produce bioethanol in sweet whey fermentation by Kluyveromyces marxianus. The results showed a maximum bioethanol concentration equal to 25.13 ± 0.37 g L-1 (p < 0.05) for formulation F6, with 1 g L-1 of L-Phe and 1.350 g L-1 of ammonium sulfate (96 h). For these conditions, the chemical oxygen demand removal percent (CODR%) was 67%. The maximum CODR% obtained was 97.5% for formulation F3 (1 g L-1 of L-Phe) at 96 hours; however, a significant decrease in bioethanol concentration (14.33 ± 2.58 g L-1) was observed. On the other hand, for formulation, F3, at 48 hours of fermentation time, a bioethanol concentration of 23.71 ± 1.26 g L-1 was observed, with 76.5% CODR%. Based on these results, we suggest that the best conditions to obtain a significant bioethanol concentration and CODR% value are those used on the configuration F3 at 48 hours.
Development of a neural network model to establish a surgical paradigm for trigeminal neuralgia patients difficult to classify
Authors: Wang Ying , Chen Hao , Jiang Xiaofeng
Published: February 2024

Backgrounds: Trigeminal neuralgia (TN) is a serious, intense and recurring pain in the sensory distribution of the trigeminal nerve in the face that is associated with decreased quality of life and increased risk of emotional disorders and physical health problems. Theoretically, TN can be divided into the classic type if vascular compression is found upon the trigeminus or the idiopathic type if vascular compression is not found upon any part of the trigeminus. Microvascular decompression (MVD) and internal neurolysis (IN) surgery are usually performed for classic or idiopathic TN, respectively, with satisfactory treatment effects. However, in clinical practice, there are patients with slight vascular contact with the trigeminus, and this is a dilemma when planning surgery because pain might be caused by this contact, which is usually insufficient to cause demyelination of the trigeminal nerve. Therefore, MVD is probably not effective and requires a second surgery, while IN is generally chosen blindly because of the high success rate along with some side effects and injury. Achieving a model with a clearer classifying boundary, especially for these patients, offers better opportunities for improved treatment efficacy.
Methods: Toward this goal, in the present study, an SVM model was constructed with resting-state fMRI data from 70 definite CTN and ITN patients. Specifically, these 70 data points were randomly assigned to the training dataset and test dataset. The linear kernel function and 2-fold cross-validation modes of SVM and feature selection were used, and the process was repeated 10 times. Features maintained in all 10 random allocations were defined as final features of the SVM model.
Results:We found that four ROI-pair connectivities were robustly effective in classification. With this model, another 16 patients with slight vascular contact who had received IN without model guidance were reclassified; 13 of these patients were classified as CTN and were likely to be appropriate for MVD.
Conclusions:Taken together, the results of the present study could guide future clinical work, and TN patients who are difficult to classify could be labeled and returned to the model for improved classification accuracy in clinical use.
Regional Development and Rural Unemployment in Low Income States
Authors: bag dinabandhu
Published: February 2024

This paper aims to determine whether the low-income states have had adequate schemes to contain short or long-run unemployment. It finds that the allocations under rural works programs could impact the short-term unemployment rates. The rural model behaves differently from urban model. It projects that a thousand new applicants to the Live register would raise unemployment by 1.66%, adding one thousand person days to rural works could reduce unemployment by 2%, and adding five new micro, small and medium enterprise (MSME) jobs could reduce unemployment by 1.2%. Since large-scale industrial development is a slower process, the low-income state may emphasize to contain rural employment. The implications of these findings lie in monitoring of the live register and objective targeting of rural works expenditure allocations within the state.
JEL cODES : A14, A10, Go, c30
Regulating the asymmetric diffusion channel in MnCo2O4 spinel enables accelerated hydrogen bond reaction kinetics of ammonia ion batteries
Authors: Liu Zhao-Qing , Xiao Kang , Xiao Bo-Hao , Li Jian-Xi , Cao Shunsheng
Published: February 2024

Transition metal oxides ion diffusion channels have been developed for ammonia-ion batteries (AIBs). However, the influence of microstructural features of diffusion channels on the storage and diffusion behavior of NH4+ is not fully unveiled. In this study, by using MnCo2O4 spinel as a model electrode, the asymmetric ion diffusion channels of MnCo2O4 have been regulated through bond length optimize strategy and investigate the effect of channel size on the diffusion process of NH4+. And the reducing channel size significantly decreases NH4+ adsorption energy, thereby accelerating hydrogen bonds formation/fracture kinetics and NH4+ reversible diffusion within 3D asymmetric channels. The optimized MnCo2O4 with oxygen vacancies/carbon nanotubes (Vo-MCO/CNTs) composite exhibits impressive specific capacity (219.2 mAh g–1 at 0.1 A g–1) and long cycle stability. The full cell with 3,4,9,10-perylenetetracarboxylic diimide (PTCDI) anode demonstrates a remarkable energy density of 52.3 Wh kg–1 and maintains 91.9% capacity after 500 cycles. This finding provides a novel approach for the development of cathode materials in AIBs.
EFE-UNet: Efficient Detection of Tunnel Cracks under Seam Linear Interference and Multiscale Crack Differences
Authors: Guo Fuyan , Cui Qi , Wang Yue , Chen Jiao
Published: February 2024

Aiming at the problems of poor continuity and low recognition rate of tunnel lining crack segmentation under the influence of seam linear interference and multi-scale differences, and the large number of model parameters, which makes it difficult to balance the efficiency and accuracy of the model well, a tunnel lining crack segmentation method based on the improved UNet network, EFE-UNet (Efficient Feature Enhancement UNet), is proposed. Initially, an EMO (Efficient MOdel) lightweight network is used to replace the VggNet backbone network in the original UNet network, which enhances the ability to describe the feature context information of the cracks and reduces the parameters of the network at the same time; BRA (Bi-Level Routing Attention) is added at the end of the encoder to implement the low-level feature selection and filter the crack information using the weights, to enhance the model's accuracy of crack segmentation. seam linear information to enhance the sensitivity of the model to the crack region and the anti-interference ability to the seam. A DSC (Depthwise Separable Convolution) and Ghost module cascaded with a DDG (Double DSC Ghost) module are used instead of the standard convolution of the decoder to reduce the model complexity and enhance the adaptability to cracks at different scales. On the Tunnel200 dataset, EFE-UNet outperforms other semantic segmentation methods with the best metrics. It also shows excellent performance on the CRACK500 dataset.
Effects of the seeds of Allium fistulosum extract on hemodynamics and myocardial oxygen consumption in dogs
Authors: Zheng Zhancai , Xu Deduo , Lu Wenquan , Wu Zhijun , Chen Wansheng
Published: February 2024

Background: The purpose of this study was to evaluate the effects of the seeds of Allium fistulosum extract (SAFE) on hemodynamics and myocardial oxygen consumption in dogs.
Method: Dog models were divided into the control group (saline, 2 mL·kg-1), SAFE low-, medium- and high-dose groups (15, 45, and 90 mg·kg-1) and the positive control group (Xingling granule, 300 mg·kg-1). Hemodynamicindices, including heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), left ventricular systolic blood pressure (LVSP), left ventricular end-diastolic blood pressure (LVEDP), maximum and minimum changes rate of left ventricular systolic blood pressure (+dp/dt max, -dp/dt max ), myocardial oxygen consumption, myocardial oxygen uptake rate, coronary blood flow, coronary resistance, cardiac output, and vascular resistance, were observed in the experimental dog models.
Results: The results showed that LVEDP, +dp/dt max and -dp/dt max were slightly and temporarily reduced in the low- and medium-dose groups, and the other indices of HR, SBP, DBP, MAP, and LVSP were not significantly affected. The results also showed that SAFE significantly decreased myocardial oxygen consumption and the myocardial oxygen uptake rate, and there were no significant effects on coronary blood flow, coronary resistance, cardiac output, and vascular resistance.
Conclusions: SAFE had no significant effect on hemodynamicindices but had significant effects on the prevention of myocardial ischemia.
Predictive Maintenance for Offshore Wind Turbines through Deep Learning and Online Clustering of Unsupervised Subsystems: A Real-World Implementation
Authors: Lützen Uwe , Beji Serdar
Published: February 2024

Enterprises in increasing numbers allocate substantial expenses to offshore wind energy development as a pivotal component of the global energy transition from fossil fuels, hence the importance of ensuring the reliability of offshore wind technology becomes ever more significant. At the same time, operation and maintenance (O&M) of offshore wind farms are progressively focusing on the integration of artificial intelligence (AI) for enhancing the efficiency and performance of the wind energy facilities. Decision support strategies based on failure predictions are an important element in this trend. As a result, AI is more frequently used to create time-to-failure predictions based on large amount of data collected from sensors deployed to wind turbines. Nevertheless, unsupervised components or subsystems may occasionally lead to failures. This paper presents a real-life example that failures in unsupervised components can be reliably predicted by the use of AI. Two different methods, Support Vector Machine and Long Short Term Memory, are presented and their limitations and advantages discussed.
TCEAL5 cooperates with the NuRD complex to epigenetically silence mesenchymal genes in glioma
Authors: Zhou Hanchi , Li Xue , Zhang Yirao , Zhang Qian , Zhou Xinwei , Zhang Daoyong
Published: February 2024

Background The TCEAL5 gene, a member of the TCEAL family, is linked to various biological processes but remains understudied in cancer research. Methods This study analyzed TCEAL5 expression in glioma and investigated its biological functions through cell assays and molecular analyses. The role of TCEAL5 in cell migration, invasion, and epithelial-mesenchymal transition (EMT) was examined, alongside its interaction with the NuRD complex. Results TCEAL5 expression was significantly lower in glioma tissues, correlating with disease progression and patient survival. Overexpression of TCEAL5 inhibited glioma cell migration and invasion, inducing a mesenchymal-to-epithelial transition. TCEAL5 was demonstrated to inhibit the expression of mesenchymal genes by recruiting the NuRD complex to the gene promoters, affecting histone acetylation and transcriptional activity. The reduced expression of TCEAL5 in glioma was partially attributed to DNA hypermethylation and gene copy number variations. Conclusions TCEAL5 functions as a potential tumor suppressor in glioma, affecting cell migration, invasion, and EMT through epigenetic regulation. Its expression correlates with disease prognosis, highlighting its potential as a biomarker and therapeutic target.
An in-silico approach to identify novel Akt1 (protein kinase B- alpha) inhibitors as anticancer drugs
Authors: Etikyala Umadevi , Reddyrajula Rajkumar , Vani T , Kuchana Vinutha , Dalimba Udayakumar , Manga Vijjulatha
Published: February 2024

Akt1 (protein kinase B) has become a major focus of attention due to its significant functionality in a variety of cellular processes and the inhibition of Akt1 could lead to a decrease in tumour growth effectively in cancer cells. In the present work, we discovered a set of novel Akt1 inhibitors by using multiple computational techniques, i.e., pharmacophore-based virtual screening, molecular docking, binding free energy calculations, and ADME properties. A five-point pharmacophore hypothesis was implemented and validated with AADRR38 including two hydrogen bond acceptors (A), hydrogen bond donor (D), and two aromatic rings (R). The obtained R2 and Q2 values are in the acceptable region with the values of 0.90 and 0.64 respectively. The generated pharmacophore model was employed for virtual screening to find out the potent Akt1 inhibitors. Further, the selected hits were subjected to molecular docking, binding free energy analysis, and refined using ADME properties. Also, we designed a series of 6-methoxybenzo[b]oxazole analogs by comprising the structural characteristics of the hits acquired from the database. Among the new series, 10 molecules were found to have strong binding interactions and binding free energy values which are comparative and even higher than the screened hits as well as higher than the active compound retrieved from the Asinex. In addition, Molecular dynamic simulation was performed to understand the conformational changes of protein-ligand complex. These results suggested that the newly designed molecules are extremely useful for further lead optimization to explore a greater number of compounds in the drug development process.
Saltus - “A Sudden Transition” Empowered by Federated Learning for Efficient Big Data Handling in Multimedia Sensor Networks
Authors: S Remya , Pillai Manu J , Sha Akhbar , Rajan Ginu , Ramasubbareddy Somula , Cho Yongyun
Published: February 2024

In the realm of sensor networks, the substantial rise in multimedia data production, covering audio, video, and acoustic measurements, has expanded the scale of big data. Multimedia Sensor Networks (MSN) excel in managing diverse sensor outputs, representations, and encoding across domains. Existing models for event detection in sensor networks fall short in handling the sheer volume and speed of these measurements from a Big Data perspective. This research work introduces “Saltus,” a model that aligns multimedia data from sensor networks to a standardized feature space. Saltus employs a machine learning-centric architecture to enhance data analysis possibilities. Crucially, the model integrates federated learning to address the evolving landscape of sensor networks. This approach optimizes the collaborative learning capabilities by allowing distributed nodes to train machine learning models locally, preserving data privacy. Saltus emerges as a solution that not only streamlines multimedia data processing but also establishes a more secure and privacy-preserving analytics framework in large-scale sensor networks. The model signifies a step forward in integrating multimedia data into an easily analyzable format, leveraging the advantages of federated learning in big data analytics.
Research on the Mechanisms of Information Overload and Information Avoidance Behavior in College Students with Psychological Disorders in the Context of Social Media
Authors: Wang Linlin , Huang Wanyu , Tang Fang , Ruan Shengnan , Peng Qingjie , Yang Ming , Mao Qiyue , Li Zhi , Jiang Qinchen , Pan Minghao , Wang Fan , Li Gang , Wei Zhu
Published: February 2024

Background:The rapid expansion of social media has given rise to a myriad of challenges among college students facing psychological distress. An abundance of fragmented and repetitive information, often referred to as information overload, inundates users on social media platforms. This inundation presents significant hurdles for college students experiencing psychological distress when acquiring and processing information. This study investigates the associative mechanisms between information overload in the context of social media and information avoidance behaviors among college students experiencing psychological distress.Methods:From May to November 2023, semi-structured interviews were conducted with 30 college students experiencing psychological distress in a prefecture-level city in Henan Province, China, to collect textual data. Grounded theory was employed to conduct three-level coding of the 30 sets of textual data. Special emphasis was placed on analyzing the process of perceiving social media information overload. Subsequently, this analysis served as the foundation for constructing a factor model influencing information avoidance behaviors among college students experiencing psychological distress.Results:The study findings indicate that, within the context of social media, college students experiencing psychological distress are prone to prolonged exposure to information overload, leading to the development of negative emotions such as anxiety and fatigue, subsequently resulting in dissatisfaction with social media. In order to alleviate these negative emotions, they employ information avoidance strategies. These strategies evolve from initially skipping or skimming information to eventually directly avoiding or even discontinuing the use of specific social media platforms. This process is not only closely linked to negative emotions but is also influenced by negative cognitive tendencies. Coupled with the role of virtual social satisfaction and social scarcity, it easily triggers social comparisons and the fear of missing out, resulting in a cyclic impact.Conclusions:Within the context of social media, information overload and information avoidance behaviors among college students experiencing psychological distress are subject to a cyclic influence stemming from negative emotions, negative cognitive tendencies, virtual social satisfaction and social scarcity, social comparisons, and the fear of missing out. This study explores the mechanisms underlying the impact of information overload and information avoidance behaviors among college students experiencing psychological distress within the context of social media. It offers valuable insights for the prevention and intervention of psychological crises among college students.
Changes in the urinary metabolome accompanied alterations in body mass and composition in women with overweight – impact of high versus low protein breakfast
Authors: Correia Banny Silva Barbosa , Dalgaard Line Barner , Thams Line , Hansen Mette , Bertram Hanne Christine
Published: February 2024

Introduction:
Understanding why subjects with overweight and with obesity vary in their response to dietary interventions is of major interest for developing personalized strategies for body mass regulation.
Objectives
The aim of this study was to investigate the relationship between changes in the urine metabolome and body mass during a breakfast meal intervention. Furthermore, we aimed to elucidate if the baseline urine metabolome could predict the response to the two types of breakfast meals (high versus low protein) during the intervention.
Methods
A total of 75 young, women with overweight were randomly allocated to one of two intervention groups: 1) High-protein (HP) or 2) low-protein (LP) breakfast as part of their habitual diet during a 12-week intervention. Beside the breakfast meal, participants were instructed to eat their habitual diet and maintain their habitual physical activity level. Nuclear magnetic resonance-based metabolomics was conducted on urine samples collected at baseline (wk 0), mid-intervention (wk 6), and at endpoint (wk 12). At baseline and endpoint, body mass was measured and DXA was used to measure lean body mass and fat mass.
Results
The baseline urine metabolite profile showed a slightly higher correlation (R2 = 0.56) to body mass in comparison with lean body mass (R2 = 0.51) and fat mass (R2 = 0.53). Baseline 24-h urinary excretion of trigonelline, N,N-dimethylglycine, and trimethylamine were significantly higher in individuals who responded with a reduction in body mass to the HP breakfast.
Conclusions
The urine metabolome could partly explain differences in the response to the HP breakfast intervention in women with overweight, indicating that the urine metabolome has the potential to unveil important information about the metabolic phenotype.
Argon Plasma Photocoagulation: A Better Alternative for Preventing Chronic Ulcer and Bleeding in Solitary Rectal Ulcer Syndrome? A Scoping Review
Authors: Ganduboina Rohit , Islam Farhad , Dutta Palak , Dhawan Ananya , Hamza Moh , Muttineni Sindhusree , Jha Gaurav , Sreeku Arjun , Keerthi Palagati , Kumar Yashaank , Gokuldas Mohini , Matthew Mohan P , Dominic Jerry Lorren , Mukherjee Indraneil
Published: February 2024

Purpose
Solitary Rectal Ulcer Syndrome (SRUS), known as "three-legged illness," involves single or multiple ulcers or hyperemic mucosa sans ulcers. With a complex, poorly understood etiology, treatment aims to address pathogenic processes. Argon Plasma Photocoagulation (APC), a novel approach for SRUS, offers potential advantages. APC is a thermal coagulation therapy that is used to halt bleeding and treat damaged tissue. This review highlights SRUS and APC efficacy vs. traditional therapy in reducing chronic ulcers and bleeding.
Method
The articles considered were obtained by performing a literature search in the PubMed, Cochrane, and Google Scholar databases, and 32 relevant articles were considered and included in the study.
Results
Conventional therapies include behavioral therapy, sucralfate enemas, bulk laxatives, high-fiber supplements, and corticosteroid therapy, with rectopexy being a viable surgical option. The literature shows a relatively higher rate of ulcer recurrence and reduced ulcer healing with conservative therapy alone. Argon plasma photocoagulation proved to demonstrate better postoperative ulcer healing, control of bleeding, and lower recurrence rates. The studies found no instances of postoperative complications like intestinal perforation, fistula formation, or infection. It is a better alternative to conventional treatments. Furthermore, APC showed higher efficacy when combined with conventional therapy in terms of treatment for SRUS.
Conclusion
Argon plasma photocoagulation has shown better postoperative ulcer healing, control of bleeding, and lower recurrence rates. Furthermore, APC showed higher efficacy when combined with conventional therapy for SRUS. Long-term prospective studies and further robust statistical support comparing APC to conventional therapies for SRUS would help us determine a treatment modality of choice with more certainty for SRUS.
Physical and Mental Benefits of 16-Week Functional Fitness Training in Older Adults
Authors: Toth Eliza E. , Vujić Aleksandar , Ihász Ferenc , Ruíz-Barquín Roberto , Szabo Attila
Published: February 2024

Functional fitness is essential in older adults. This study assessed the physical and mental effects of a 16-week exercise intervention based on the Fullerton Functional Fitness Test (FFFT) in adults over 60. Thirty-eight participants (66% women), Mage = 80.15, SD = 7.21, were randomized into exercise (n = 24) and waiting list control (n = 14) groups. The former trained thrice weekly for one hour. Objective tests (FFFT and handgrip power) and subjective psychological measures (life satisfaction, resilience, happiness, perceived stress, and well-being) were evaluated at baseline, after eight weeks, and after 16 weeks. The data were analyzed using mixed-effect regression models. Post-hoc analyses revealed the group differences. The results yielded statistically significant interaction effects (group × time) in all models, indicating improvements in physical and psychological measures over time in the treatment group compared to the control group. Furthermore, significant differences between the groups in estimated marginal means (with adjusted 95% confidence intervals) emerged in happiness after 16 weeks (-3.5 [-6.5, -0.4]), resilience (-5.5 [-9.9, -1.2]), perceived stress (2.2 [0.2, 4.2]), well-being (-5.8 [-7.9, -3.6]), upper limb strength (-5.7 [-9.0, -2.4]), upper body flexibility (-8.7 [-16.4, -1.0]), and agility and balance (4.6 [1.2, 8.1]). Among these measures, the differences existed even after 8-weeks, except for happiness and resilience. In conclusion, functional fitness training lasting only 16 weeks can benefit older adults both physically and mentally.
An Intelligent Evaluation Method of Business English Translation Ability Based on Collaborative Game Particle Swarm Algorithm
Authors: Yu Feng , Zhou Wei , Zhang Yu
Published: February 2024

In today's globalized business climate, translation is essential for promoting successful communication. For precise and dependable communication, it is crucial to assess the translation skills of experts in the area of business English. However, the current evaluation techniques frequently lack clever and team-based methodologies to evaluate translation talents completely. In order to fill this gap, the Collaborative Game Particle Swarm Algorithm (CGPSA) is used in this study to present an intelligent evaluation approach for Business English translation proficiency. The CGPSA develops an interesting and efficient evaluation procedure by fusing the ideas of game theory and particle swarm optimization (PSO). The development of computerized sentence recognition that is specifically adapted to the features of business English has been greatly aided by the CGPSA. The CGPSA has been used to collect, organize, and analyze data, enabling sophisticated identification of business English. With a total score of 93.4, the suggested framework's results show high recognition accuracy. The findings show that in terms of accuracy in recognition, frequency magnitude, and intelligent translation, the CGPSA-based assessment technique performs better than conventional evaluation methodologies.
Acinetobacter lentus sp. nov. isolated from Landfill
Authors: Xia Mengli , He Mingxiong , Wang Yanwei , Wu Bo , Hu Guoquan , Zhao Yuandong
Published: February 2024

The taxonomic position of strain CAAS 2-6T, a Gram-negative, aerobic, non-motile, mesophilic bacterium with positive catalase and negative oxidase activity, isolated from Chang'an Landfill in the Longquan Mountains, China. The 16S rRNA gene sequence (1459 bp) of strain CAAS 2-6T showed high sequence similarity to A. gerneri DSM 14967T (97.74%), followed by A. kanungonis PS-1T (97.60%) and A. tandoii DSM 14970T (97.53%). Phylogenetic analyses based on 16S rRNA, rpoB and gyrB gene sequences, together with DNA–DNA hybridization values less than 70 %, indicated that strain CAAS 2-6T belongs to the genus Acinetobacter and may represent a novel species. Genome sequencing revealed a genome size of 4.829 Mbp and a G + C content of 57.13 mol%. Major fatty acids identified were Summed Feature 3 (25.78%), C16:0 (25.74%), C18:1 ω9c (10.46%), C12:0 (6.96%) and C16:0 N alcohol (6.45%). The polar lipid profile of strain CAAS 2-6T revealed the presence of phosphatidylglycerol, phosphatidylcholine, and diphosphatidylglycerol. Based on phenotypic, phenotypic and biochemical characteristics, strain CAAS 2-6T was clearly distinct from the type strains of other recognized species in the genus Acinetobacter, suggesting that it represents a novel species of the genus Acinetobacter. Therefore, the name Acinetobacter lentus sp. nov. is proposed. The type strain is CAAS 2-6T (= GDMCC 1.3951T = KCTC 8156T = JCM 36321T).
A Model-based approach for the preliminary design of the SAR Upstream element for the Italian IRIDE EO constellation based on users’ demand
Authors: Conti Federica , Eugeni Marco , Marzioli Paolo , Pasquali Michele , Schiavon Emma , Xuan Alessandra Nguyen , Tornato Antonella , Geraldini Serena , Piergentili Fabrizio , Taramelli Andrea , Gaudenzi Paolo
Published: February 2024

Traditional approaches to the design of satellite constellations are typically related to technical conditions and financial effort. The use of optimization methods is limited to design specific technical performances of the single spacecraft, missing to resort to a holistic view of the whole mission including user needs. Given the growing significance of large Low Earth Orbit (LEO) constellations of small satellites in Earth Observation, there is a pressing need to develop design tools that can incorporate user needs into the overall preliminary design process of a constellation. This paper aims to formulate and preliminarily test a systematic model-based approach capable of integrating user needs within the entire preliminary design process of a constellation architecture. The purpose of the methodology is to identify cost-effective architectures for more detailed design studies and to propose optimal solutions to fulfill the variety of requests from users. It is composed of five major steps: formulation, enumeration, simulation, evaluation, and down-selection. As a case study, the proposed approach is implemented to define the preliminary architecture of the Synthetic Aperture Radar (SAR) sub-constellation within the IRIDE Italian program. Performance is assessed based on the percentage of satisfied user needs and the volume of downlinked data to ground stations. Five optimal SAR constellations are proposed. Results demonstrate that the approach provides a valuable tool for the optimal preliminary design of a satellite infrastructure, taking into account not only technical performance but also user needs throughout the entire design process.