bluuebunny/crossref_metadata_2025 huggingface dataset:
Early postnatal activation of A2ARs alleviates social deficits by attenuating the abnormal infiltration of peripheral neutrophils in the BTBR T + Itpr3 tf /J mouse model of autism
Authors: He Xie , Zhou Mi , Yang Teng , Ren Jia-Kui , Sun Li , Liu Tian-Yao , Sun Jian-Bin , Ma Peng-Jiao , Liu He-Ting , Fang Jing-Qin , Dai Shuang-Shuang
Published: November 2022

Background
Previous studies have mainly focused on the immediate effect of drugs on autism spectrum disorders (ASDs) and complex heterogeneous neurodevelopmental disorders that have been proven to be involved with the chronic inflammation of the central nervous system. Our prior work has explored the positive role of activation of adenosine 2A receptors (A2ARs) in protecting adult BTBR T+ Itpr3tf/J mice against autism-related behaviour from the early postnatal period. However, the exact mechanism underlying the protection of A2ARs has not been comprehensively investigated.
Methods
The persistent protection of early postnatal activation of A2ARs in adult BTBR mice was detected utilizing behaviour tests. Pathological variation in the peripheral blood of autism patients was analysed by transcriptomic analysis, including MROAST and protein–protein interaction (PPI) analysis. The clues were further explored and validated by real-time (RT) PCR, western blotting, immunohistochemistry and transcriptomic analysis in the mouse cortex. The blood brain barrier of mice was identified by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI).
Results
Abnormal activation of myeloid cells, especially neutrophils, was detected in the peripheral blood of autism patients and the BTBR mouse cortex. The BBB permeability of BTBR mice was significantly increased, which may have facilitated the abnormal infiltration of neutrophils observed in the BTBR mouse cortex. Furthermore, the early postnatal activation of A2ARs effectively reverses the abnormal activation and invasion of neutrophils in the mouse cortex and might result in the significant moderation of autism-related behaviour in adult BTBR mice, followed by a decrease in chronic inflammation in the mouse cortex during the early postnatal period.
Conclusions
We found abnormal myeloid cells in autism patients and BTBR mice and increased infiltration of neutrophils in the mouse cortex. We concluded that the early activation of A2ARs could effectively decrease the autism-related behaviour of adult BTBR mice by reversing the abnormal activation of myeloid cells and the pathological invasion of neutrophils in the mouse cortex.
Histopathological diagnosis of oral lesions at a Pathology Institute in Brazil
Authors: Zimmer Jordana , Garbin Raíssa Rigo , Vogel Mayara , Rigo Lilian
Published: November 2022

Background: This study analyzed the most prevalent diagnoses of oral lesions submitted to biopsy using data from a pathology laboratory and associations between malignant and oral potentially malignant disorders with patient’s demographic variables and the anatomical location.
Methods: This is a cross-sectional study. All 1,298 histopathological reports of oral lesions recorded in the database of the Institute of Pathology were reviewed. Demographic variables, anatomical location of the lesion, histopathological diagnosis of the lesions and their biological behavior were analyzed using a logistic regression.
Results: Regarding the biological behavior of the identified lesions, benign lesions were predominant (70%), followed by lesions of undetermined behavior (14.3%), malignant lesions (14.2%), absence of histological alteration in the sample (1.2%), and finally, oral potentially malignant disorders (0.5%). The anatomical locations of the most prevalent oral lesions potentially malignant disorders and malignant were in the following structures of the oral cavity: gums, roof of the mouth, floor of the mouth, inner lining of the cheeks (P=49.2%), and tongue (P=48.7%). In the final adjusted model, the probability of malignant and premalignant lesions was higher among males (PR= 4.21; 95% CI 2.08-6.22), the increase in age (PR = 1.06; 95% CI 1, 05-1.08), and in the tongue region (PR = 5.48; 95% CI 1.67; 17.92).
Conclusion: This study suggests that the probability of identifying malignant and oral potentially malignant disorders is higher in males whit age advanced and specimens from the tongue.
Successful management of an epicardial cyst in a 22-year-old female: A Case Report And Literature Review
Authors: Mansour Marah , Safi Ahmad , Fedawi Omar , Deeb Dani , Zgeib Habeb , Sawan Tawfek , Sakbani Maram , Rajab Samer
Published: November 2022

Background

Pericardial cysts are rare benign lesions that can be caused by echinococcosis and have an incidence rate of about 1 in 100,000. They are usually detected incidentally because they are asymptomatic in most cases but can lead to serious complications if left untreated.

Case presentation

A 22-year-old female presented with generalized pruritus, and a productive cough but without any chest pain or dyspnea. The chest X-ray and computed tomography showed hydatid cysts in the left superior and inferior lobes of the left lung but after opening the chest, lung lobes were discovered to be intact with clear pericardium distension.

Conclusions

This case aims to highlight the importance of performing a thorough examination with radiological investigations to determine the connection between the cyst and the pericardium and to distinguish a pericardium cyst from a lung cyst. Since the majority of cases are asymptomatic, thus symptoms and chest X-rays cannot be used solely to establish an accurate diagnosis.
A comparison of two methods for quantifying ant diversity and community in an East Himalayan montane forest mosaic
Authors: Zhang Chuan-Jing , Cheng Yi-Ting , Luo Xian-Shu , Chen Yao , He Yu-Chao , Li Yan-Pang , Huang Zhi-Pang , Scott Matthew B. , Xiao Wen
Published: November 2022

Sampling efficiency, composition and detection biases associated with pitfall-trap and sample plot methods were compared at seven montane sites at Lasha Mountain, Yunnan, China. On average, sample plot samples contained 1.5 times more taxa than pitfall-trap samples; however, we found no significant difference between of alpha and beta diversity in pitfall-trap and sample plot site samples. Rarefaction-interpolations curves revealed significantly higher total diversity from sample plot methods; that sample plot methods would require three times more sampling to reach asymptote of true diversity; and that sample plot samples achieve higher sample coverage across sample sizes. Permutational multivariate analysis of variance showed community composition and dominant species differed between methods. Of all taxa collected, the two methods had 16 species in common, accounting for 52% of the total species; 29% were exclusive to sample plot samples and 16% were exclusive to pitfall traps. Implications for insect conservation: Our findings suggest that results from the two methods cannot be directly compared and are imperfect substitutes to one another. For long-term monitoring of biodiversity, we suggest integrating multiple complementary methods, including standardised active collection methods, such as the sample plot method, to achieve more complete representation of ant composition and diversity.
Development of an interpretable deep learning system for the identification of patients with Alzheimer’s disease
Authors: Atnafu Selamawet Workalemahu , Diciotti Stefano
Published: November 2022

Deep learning using convolutional neural networks has shown great promise in analyzing neuroimaging data. Identification of Alzheimer's Disease patients from healthy individuals using structural magnetic resonance data is one of the clinical problems that has been widely explored by employing convolutional neural networks and producing very high classification accuracies. However, in most studies, the results were not supported by explainability tools. In this study, an interpretable convolutional neural network model derived from pre-trained VGG-16 is proposed to classify Alzheimer’s Disease patients vs. healthy subjects using MRI data obtained from an Open Access Series of Imaging studies (OASIS) dataset. The model was trained and validated based on a 5-fold cross-validation loop and produced a classification accuracy of 71.62% on the validation set. Moreover, we incorporated four CNN visualization techniques that highlight important brain regions used by the model to identify AD patients: saliency map, gradient class activation mapping, occlusion mapping, and heatmap generated by Shapley additive explanation (SHAP) method. The potential of these explainability tools in identifying biased models that produce inflated erroneous results is also investigated, and the resulting heatmaps were able to indicate a bias in the model’s training procedure.
A Diagnostic Model of Autoimmune Hepatitis Based on Noninvasive Clinical Data
Authors: yang haiyan , Jianjun HU
Published: November 2022

Background & Aims All the diagnostic criteria of autoimmune hepatitis (AIH) include histopathology, which is of great significance for the final diagnosis in AIH patients. Nevertheless, some patients fail to receive this examination in time because of the fear of the trauma risk of liver biopsy. Therefore, we aimed to develop an AIH diagnostic predictive model without liver biopsy in adults and validate its performance.
Methods We collected demographic, blood and liver histological data of unknown liver injury (ULI) patients. First, we conducted a retrospective cohort study in two independent adult cohorts. In the training cohort (n=127), we used logistic regression to develop a nomogram according to the Akaike information criterion (AIC). Second, in the validation cohort, we used receiver operating characteristic (ROC) curves, decision curve analysis and calibration plots to externally evaluate the performance of this model. Third, we calculated the optimal cutoff values of diagnosis using Youden's index (sensitivity+specificity-1) and presented the sensitivity, specificity and accuracy to evaluate the model in validation cohort compared with 2008 IAIHG simplified scoring system.
Results In the training cohort, we developed a model to predict the risk of AIH using four risk factors—percentage of gamma globulin (GGP), fibrinogen (FBG), Age and AIH-related autoantibodies (AA). In the validation cohort, the areas under the curve (AUC) for the validation cohorts were 0,796. The calibration plots suggested that the model had an acceptable accuracy (p＞0.05). The decision curve analysis (DCA) suggested that the model had great clinical utility if the value of probability was 0.45. Based on the cutoff values, the model had a sensitivity of 68.75%, a specificity of 76.62%, and an accuracy of 73.60% in the validation cohort. While we diagnosed the validated population by using the 2008 diagnostic criteria, the sensitivity of prediction results was 77.77%, the specificity was 89.61% and the accuracy was 83.20%.
Conclusions The new model we operated can be used to predict AIH for ULI patients without liver biopsy. It is an objective, simple and reliable method that can effectively be applied in the clinic. Furthermore, if our model predicts a high risk of AIH, we can also persuade patients, especially those who are in the hesitant stage, to do a liver biopsy. This model is a valuable supplement to the 2008 IAIHG simplified scoring system.
Green areas state assessment within the urban territories
Authors: Shestopalov Oleksii , Tykhomyrova Tetyana , Lebedev Volodymyr , Stadnik Veronika
Published: November 2022

The urbanized environment is a complex heterogeneous system that is constantly changing. In large cities, there is a complex stress effect on living organisms. Different areas of the city may be permanently or temporarily dominated by a certain stress factor. Vegetation is a component of urban landscapes, which are natural and artificial objects of various functional purposes. The ecological functions of green spaces include: environmental protection, environmental regulation and aesthetic functions. All these functions play an important role within residential buildings, especially in children's playgrounds. Various types of damage to green spaces negatively affect their main functions. The susceptibility to damage of woody plants by insects depends on anthropogenic factors of the environment, which lead to the weakening of plants and to the loss of resistance to these types of negative influences. The resistance of plants to diseases often decreases under the influence of transport and industrial pollution in the external environment. The purpose of the study is phytopathological analysis of the green areas state on children's playgrounds in Kharkiv. Green plantations state assessment methods of urban areas using various technical means are analyzed. green plantings condition and morbidity analysis using one of the offered methods is carried out. According to the results of phytopathological analysis, it was determined that 100 % of the species Aesculus hippocastanum L., which grow on playgrounds in Kharkiv, are affected by Cameraria ohridella. Among the bushes, Syringa vulgaris L. and Spiraea L. are the most affected by diseases and pests
Sistem Prediksi Curah Hujan Bulanan Menggunakan Jaringan Saraf Tiruan Backpropagation
Authors: Sunardi Sunardi , Yudhana Anton , Muflih Ghufron Zaida
Published: November 2022

Rainfall has important role for human life. Rainfall information can be used in several fields including agriculture. As a benchmark for planting periods, water infiltration management, and irrigation. The resources for calculating rainfall are rainfall gauges, ground-based radars and remote sensing satellites. Wonosobo area’s rainfall type is monsoon, meaning that it has one wet period and one dry period. It has fluctuating varied rainfall every month and the availability of rainfall data is uncertain each year. As a mountainous area, Wonosobo’s agricultural sector is very dominant for their economic. Weather Observation, especially rainfall, is important because it can be used by related parties, especially in the agricultural sector. In addition, to provide rainfall data in areas with no observation stations. This study aims to design and implement a rainfall prediction system by developing the Waterfall Model Development Life Cycle (SDLC) Software and implementing backpropagation artificial neural networks (ANN). System development using the SDLC waterfall model was chosen because it is simple, easy to understand and implement. ANN backpropagation is applied in the prediction system because of its advantage that can be applied to a problem related to prediction. Testing on the system built for training and validation produces training accuracy of 93.92% with validation of 73.04%, indicating that the system can be used and has been running expectedly. The best ANN architecture was obtained on the test with input layer 3, hidden layer 12, and output 1 values, learning rate 0.5 momentum 0.9. From the SSE 0.1 target, the SSE is 0.302868.
Impact of claim settlement procedure of health insurance companies on customer satisfaction during the pandemic: A case of third-party administrators
Authors: Kadyan Sunil , Bhasin Narinder , Madhukar Vikas
Published: November 2022

The claim settlement process is one of the most critical aspects of health insurance. Many policyholder grievances often surface during claim settlement, which will likely shape the insurer’s reputation. Hence, this study aims to evaluate the relationships between hypothesized factors concerning the third-party administrator’s claim settlement process as perceived by policyholders. The paper used the data of policyholders from Delhi/NCR, India, who have availed the cashless claims in the last three years. In the process, a total of 790 questionnaires were sought to be. The methodology used was the extractive factor analysis comprising the KMO test, reliability assessment with Cronbach’s Alpha, and correlation assessment. The study attempted to evaluate all the contributing factors that shape the third-party administrator’s behavior during the claim settlement. Therefore, different factors were identified (themes A, B, C, and D). The study reported a significant relationship between insurance company perceptions (0.162), network hospital perceptions (0.182), product design (0.180), insurance agent (0.332), communications (0.114), disclosure (0.122), internal practices (0.143), and TPA claim settlement prospects across the Indian perspective. The contextual impacts on individual and group decision-making must be monitored and accommodated across effective public policy management concerning settlement of health insurance claims. The study findings could help insurers create business models leading to better customer satisfaction and congruence between agents, policyholders, TPAs, and health insurance companies.
Organoleptic and Quality Characteristics of Malagousia Variety, Grapes Fermented with Selected Indigenous Yeast Strains
Authors: Karampatea A. , Vrhovšek Ur. , Tsakiris A. , Dimopoulou M. , Kourkoutas Y. , Skavdis G.
Published: November 2022

Commercial Malagousia varietal wines, which are produced in almost all Greek viticultural zones, represent a relatively important part of Greek wine activity. This study presents the results of a profile compilation of volatile aroma compounds of Malagousia musts fermented under identical conditions with selected yeast strains. In total, 62 volatile aroma compounds were identified and separated into their chemical classes (aldehydes, higher alcohols, volatile phenols, terpenes, C13-norisoprenoids, lactones, esters, fatty acids, sulphur compounds, other compounds, and other alcohols). Alcohols and higher alcohols, such as cis-hexen- 1-ol and geraniol, terpenes like linalool, esters such as ethyl isovalerate, ketones such us betadamascenone, beta-ionone and zingerone, and fatty acids such as geranic acid and phenylacetaldehyde, were found in all the samples. Among them, linalool and phenylacetaldehyde had the strongest effect on the volatile compound profile of Malagousia wines. The same wine samples were subjected to sensorial analysis by a trained panel of 10 wine tasters, and a statistical analysis of both analyses presents similarities between the two analysis approaches. It is hoped that the results will contribute to a better understanding of the quality potential of the Malagousia variety so as to evaluate possible differences on the basis of the detected aroma concentrations.
An Assessment of Treated Municipal Wastewater Used for Irrigation of Grapevines with Respect to Water Quality and Nutrient Load Assessment of TMW for vineyard irrigation
Authors: Howell C. L. , Hoogendijk K. , Myburgh P.A. , Lategan E. L.
Published: November 2022

The impact of treated municipal wastewater (TMW) irrigation on soil and grapevines was assessed under field conditions in vineyards in the Coastal region of South Africa. Grapevines were irrigated using TMW from the City of Cape Town uninterruptedly over a period of 11 years. Grapevines were either rain fed, irrigated with TMW via a single dripper line, or received twice the volume via double dripper lines. The quality of the TMW used for vineyard irrigation was acceptable, and below the minimum criteria stipulated by the General Authorisations to irrigate up to 500 m3 per day in terms of pH, ECw and SAR. Mean Na+ concentration in the TMW exceeded the critical value of 100 mg/ℓ for irrigating grapevines in South Africa. The Cl- levels in the TMW were well below the threshold value of 700 mg/ℓ at which toxicity in grapevines might occur. Consistently high P concentrations measured in the TMW could lead to the formation of algal blooms in water storage facilities and bio-fouling of irrigation equipment. The low N content in the TMW could not supply the annual N requirement of grapevines. The annual amount of P applied via the single dripper lines was slightly below grapevine requirements, whereas double the TMW irrigation applied excessive amounts of P. Amounts of K+ applied via TMW irrigation was in excess of annual grapevine requirements, which could affect wine quality negatively. The amount of Ca2+ and Mg2+ applied via the TMW also exceeded annual grapevine requirements.
Biometría y morfometría comparada de las subespecies de escribano palustre, Emberiza schoeniclus witherbyi y E. s. schoeniclus en el valle del Ebro
Authors: Mazuelas David , Gutiérrez Oscar
Published: November 2022

El escribano palustre iberoriental está catalogado como “en peligro de extinción”. Sus zonas de cría son generalmente bien conocidas, pero no lo son tanto sus posibles desplazamientos fuera de la época reproductora ni sus localidades de invernada, periodo en la que coincide con numerosos palustres de procedencia europea. Por ello es muy importante distinguir ambas subespecies. Se realiza el estudio biométrico más completo hasta la fecha de las dos subespecies de escribano palustre presentes en el valle del río Ebro, la iberoriental E.s. witherbyi y la norteña E.s. schoeniclus. Los resultados muestran diferencias significativas entre subespecies, aunque las diferencias entre sexos o edades dentro de la misma subespecie no arrojó resultados significativos. La gran curvatura del culmen en la mandíbula superior de E.s. witherbyi resulta distinguible cuando se compara con el culmen, mucho más aplanado, de E.s. schoeniclus. Con el detallado estudio biométrico realizado, con medidas estandarizadas y testadas, se ha generado una sencilla función discriminante [D = (Altopico*5,2)-(Ala*0,13)-15] para separar ambas subespecies de forma segura, en la que los valores mayores a cinco determinan a E.s. witherbyi, y los menores de cinco a E.s. schoeniclus en el 100% de los casos estudiados.
Water insecurity and sexual and gender-based violence among refugee youth: qualitative insights from a humanitarian setting in Uganda
Authors: Logie Carmen H. , Okumu Moses , Coelho Madelaine , Loutet Miranda G. , Narasimhan Manjulaa , Lukone Simon Odong , Kisubi Nelson , Musoke Daniel Kibuuka , Kyambadde Peter , Dorea Caetano , Taing Lina
Published: November 2022

Refugee youth disproportionately experience sexual and gender-based violence (SGBV) and water insecurity, yet their SGBV experiences in the context of water insecurity are understudied. In this qualitative study, we conducted six focus groups (n = 48) and in-depth individual interviews (IDI) (n = 12) with refugee youth aged 16–24, and IDI with refugee elders (n = 8) in Bidi Bidi Refugee Settlement, Uganda. We applied thematic analysis informed by a social contextual framework and found that (1) SGBV is gendered, whereby adolescent girls and young women (AGYW) were targets for violence (symbolic context), and is intertwined with gender norms linked to AGYW's water collection roles (relational context); (2) water scarcity and off-site access to water infrastructure, combined with limited lighting, provide insecure environments that exacerbate AGYW's SGBV risks (material context); (3) participant generated solutions to water insecurity-related SGBV included engaging men and communities in dialogue and water collection (relational context), technology (e.g., solar lighting), improved security, and additional water points (material context). Findings signal the need to integrate water and sanitation hygiene development with SGBV prevention and sexual health (e.g., post-rape care) interventions. Refugee youth and communities should be meaningfully engaged in developing contextually relevant, gender transformative services to mitigate SGBV risks and advance health and rights.
Decolorization of methyl red using Bacillus thuringiensis RI16 strain: Enhanced bacterial treatment by SPB1 biosurfactant addition
Authors: Mnif Ines , Fendri Raouia , Ghribi Dhouha
Published: November 2022

In this work, we evaluate the ability of a novel isolated bacteria identified as Bacillus thuringiensis RI16 (KM111604) to decolorize methyl red. Results showed its efficiency for the treatment of azo-dye-contaminated wastewaters under static conditions at pH values ranging from 7 to 9. The isolated bacteria could tolerate higher doses of dyes as it was able to decolorize up to 1000 mg/L. For better methyl red decolorization, we evaluate the potential use of Bacillus subtilis SPB1-derived lipopeptide biosurfactant. The study showed its ability to accelerate the decolorization rate and slightly maximized the decolorization efficiency at an optimal concentration of 0.025%. Compared with synthetic surfactants, the bacterial surfactant was more efficient as we observe a drastic decrease and an inhibition of methyl red decolorization by cetyl trimethylammonium bromide (CTAB) and sodium dodecyl sulfate (SDS) additions. Also, studies ensured that methyl red removal by this strain could be due to extracellular enzymatic activities. SPB1 biosurfactant could improve enzyme activities and/or enzyme synthesis and diffusion.
Phase I Cardiac Rehabilitation Intervention in Patients Undergoing Coronary Artery Bypass Grafting
Authors: Galih Ardhani , Tri Tjahjono Cholid , Rizal Ardian , Martini Heny
Published: November 2022

Patients undergoing coronary artery bypass grafting (CABG) have a risk of postoperative complications that result in prolonged hospitalization and even death. Interventions in the form of phase I cardiac rehabilitation are needed to help speed up the postoperative recovery process and prevent complications after CABG. Although a lot of research has been carried out, it is necessary to conduct further studies of research articles regarding interventions that can be carried out in cardiac rehabilitation programs that are safe and easy to perform in postoperative CABG patients. The purpose of this literature review was to examine safe and effective interven- tions in phase I cardiac rehabilitation in patients undergoing CABG. The implementation of phase I cardiac rehabilitation in patients undergoing CABG started from the preoperative phase and continued postoperatively until the patient was discharged. Phase I cardiac rehabilitation interventions, both pre and postoperative, consist of education and counselling, physical exercise, breathing exercises, effective coughing exercises, inspiratory muscle training, and chest physiotherapy. The results of this literature review can be used as a basis for determin- ing standard operating procedures for the implementation of phase I cardiac rehabilitation for hospitals that provide CABG services.
Symptomatic Bradycardia In CAD Patient: Which One First To Treat?
Authors: Yuwono Suprapta Aloysius , Saifur Rohman Mohammad , Rizal Ardian , Widito Sasmojo
Published: November 2022

Background: The incidence of sinus node dysfunction (SND) increases with age. Likewise, the incidence of coronary artery disease (CAD) has increased from year to year in Indonesia. When doctors are faced SND patients with CAD, it can be confusing in determining initial treatment options. Objective: This study aimed to describe the diagnosis and management of SND in CAD patient. Case Presentation: We will discuss a 75 years old male who had schedule to management of bradycardia symptomatic related to SND. Five month before admission, he had acute coronary syndrome, and had 2 DES implantation at left main (LM) to proximal left anterior descendent (LAD) artery and mid LAD. Two months after PCI he felt near syncope with bradycardia. Evaluation with ambulatory EKG was performed with result of SND, and correction of reversible cause related to SND already done. Eventually, symptom still exist and PPM insertion was decided to perform. Conclusion: Patients with SND and CAD have a higher risk of complications and death. Correction of reversible factors, one of which is CAD, can be done as an initial step in the treatment of SND. When symptomatic signs still appear after correction of reversible causes, PPM implantation is the modality of choice in management.
EFFECT OF GAMIFICATION ON EDUCATION AND LEARNING (Preprint)
Authors: Ryzhkov Georgiy
Published: November 2022

BACKGROUND

This research paper is about a phenomenon called gamification and its effects on our way of learning and education as a whole. Gamification is a tool or a feature used to bring the elements of games (typically video games) into different non-game fields like sports, marketing, and education in order to enhance the effectiveness of such fields. This research paper will further discuss where gamification came from, how it affects our motivation, and of course, how it helps us learn and encode new information in the easiest way possible. 

OBJECTIVE

Find out how gamification affects the learning and motivation in students

METHODS

Analyzing research papers, studies, and other articles to understand the psychology behind gamification.

RESULTS

Gamification is directly affecting our way of learning through external and internal motivators and cognitive psychology.

CONCLUSIONS

Gamification is directly affecting our way of learning through external and internal motivators and cognitive psychology
The Problem and Countermeasure of Party Branch leading Cooperative—A Case on A Rural Tourism Cooperative Led by Party Branch in B Village of Shandong Province
Authors: Wei Yuxin
Published: November 2022

Taking the typical rural tourism cooperative led by the Party branch in B village of Shandong Province as an example, this paper discusses the causes, concrete practices, practical effects and existing problems of the party branch led rural tourism cooperative through case analysis with exploratory empirical research method. Research shows that: First, the motivation of the establishment of the cooperative led by the Party branch lies in the weakening and marginalization of the party branch, the decline of the industry and the collective poverty, and the weak collective consciousness of the villagers. Second, the party branch to lead the cooperative needs the village Party branch to raise energy and empower, integrate resources in the form of internal source and external transmission, and combine “internet +”intelligent management. Third, the party branch leads the cooperative to enhance the power of the party branch, industrial development file upgrade, community consciousness return. Research suggests that: In the new era, the party branch leads the cooperatives to promote the modernization of agriculture and rural areas, reorganize farmers and self-organize them, reconstruct the rural governance pattern and build a harmonious rural society. Its rise has realistic necessity and rationality.
Designing and Explaining the Structural Model of Financial Agility of the Supply Chain Process of Commercial Companies in Iran with a Combined Approach
Authors: Khalilzade Reza , Saeidi Parviz
Published: November 2022

The population of participants in this study included academic and industry experts that the number of samples was selected based on the method of snowball sampling to people. In data analysis, first, codes and components of financial agility were extracted from the interviews and developed in the form of a conceptual data model of the foundation. The central category was financial agility, which was presented in 3 dimensions, as well as causal, contextual, intervening conditions, strategies and results, and the final model was presented. Then, using Delphi analysis method, design questionnaire and initial model were presented by experts in correction, approval and financial streamlining model of supply chain process of commercial companies in Iran. Second-order factor analysis and Structural Equation Modeling (SEM) have been used. In general, the research findings of this section also showed that there is a significant relationship between causal conditions and the central category. the results of this study, the main categories of the developed model include intra-organizational, technological and human factors of financial agility of the supply chain process of commercial companies in Iran, based on which the expected consequences of the financial agility model can be achieved.
A SINGLE-BLIND, PLACEBO-CONTROLLED CLINICAL TRIAL OF LOCAL APPLICATION OF KOHL-CHIKNI DAWA-A UNANI COMPOUND FORMULATION IN THE PATIENTS WITH CORNEAL OPACITY
Authors: ZAIDI ZEHRA , NAZIR SHEHLA
Published: November 2022

Objective: The present clinical trial was undertaken to evaluate the safety, preventive/curative efficacy of the local application of Kohl-Chikni Dawa (KCD) in patients with corneal opacity (CO), to provide an economic, safe, and effective alternative treatment for it.
Methods: The present prospective single-blind, placebo-controlled trial was undertaken at Majeedia Hospital, Hamdard University, New Delhi. Ninety-two diagnosed patients of CO were randomly allocated to three groups for local application of KCD/placebo two sticks BID.
Results: Forty patients completed the 6-month duration of the study. KCD was found effective in the general amelioration of the signs and symptoms of CO. There was a statistically significant reduction in the CO score and improvement in vision on the reading of the Snellen chart in the test drug group in comparison to the placebo group in Grade-I (Nebular type) CO (p>0.05).
Conclusion: KCD was found very much effective to reduce the CO score, with clinical improvement of vision in the nebular type of CO. The dose of KCD in two sticks BID was found safe and tolerable with no side effects. A multicentric trial of the test drug on larger sample size for a longer duration is required to establish the efficacy of the formulation on CO.
ASSESSMENT OF ANTI-OBESITY ACTIVITY OF TECTONA GRANDIS LEAVES ON BUTTER INDUCED HYPERLIPIDEMIA IN MICE
Authors: PRASANNA JAKKA LAKSHMI , RAO NAKKA MADHAVA , KUMAR REDDY BADDIGAM VENKATA SAI
Published: November 2022

Introduction: Obesity is one of the world’s leading problems, which is major cause of cardiovascular diseases. During COVID-19 pandemic many young children and all age group people are getting challenged by obesity due stagnant life style. To treat such life-threatening disorder natural remedies acquire prior position, plant produces a good deal of secondary metabolites which have a benefited mankind in various ways, including treatment of diseases. The present research work was focused on developing a natural remedy using Tectona grandis, an ancient plant with number of proven activities in traditional medicine.
Methods: In the literature survey, it was found that flavonoids, sterols, tannins, and alkaloids shown promising effects to tackle obesity by various mechanisms, T. grandis has shown the presence of saponins, alkaloids, flavonoids, proteins, and amino acids. With the above evidence, this plant has been selected for screening of its antiobesity activity against high-fat diet induced obesity in mice. Studies were conducted using aqueous extract of T. grandis leaves (AETG) on high-fat diet (butter) induced model of hyperlipidemia in mice. During 21 days’ time period AETI low and high doses were induced to respective animal groups along with butter where atorvastatin has been taken as standard drug. Butter enhanced the cholesterol and triglyceride, low-density lipoprotein (LDL) levels.
Results and Discussion: At the end of 21 days, blood samples were collected from the animal through retroperitoneal route. Biochemical parameters of AETG have been compared with that of standard drug group of animals. The test results were almost similar and for some particular parameters such as LDL and very low-density lipoprotein, AETG shown good results than standard drug results.
Conclusion: In congruence with these results, it may be confirmed that due to the presence of phytoconstituents such as saponins, flavonoids, proteins, terpenoids, amino acids, and alkaloids in the aqueous extract of T. grandis, it could be responsible for the observed significant anti-obesity activity.
A COMPARATIVE STUDY OF DRAINAGE OF BREAST ABSCESS BY CONVENTIONAL INCISION AND DRAINAGE VERSUS SUCTION DRAINAGE VERSUS ULTRASOUND-GUIDED NEEDLE ASPIRATION
Authors: CHORMA ANKIT , PARGI ARUN KUMAR , YADAV RINKU
Published: November 2022

Objectives: Breast abscesses are common among lactating women most prevalent in developing countries because of poor hygiene, malnutrition, and health conditions. In era of technical advances management of breast abscess has shifted to minimally invasive and painless techniques which are more patient friendly. This study compare outcomes in management of breast abscess by ultrasound-guided needle aspiration, suction drainage, and incision and drainage procedure.
Methods: The present study was conducted in department of surgery in collaboration of MGM Medical College Indore with Government Medical College, Khandwa. A total 120 patients of breast abscess were divided in three groups. One group was managed by incision and drainage second group by suction drainage and third group by ultrasound-guided needle aspiration (40 patients in each group).
Results: In our study, total 120 patients were analyzed, majority of the cases (40.8%) belong to 21–25 years age group. Post-operative pain, high recurrence rate, fistula formation, cessation of breast feeding, ugly scar formation, and longer duration of hospital stay were observed in incision and drainage procedure.
Conclusions: USG-guided needle aspiration was the safest, cost effective, and widely accepted procedure in the treatment of breast abscess as compared to incision and drainage.
CLINICAL INSIGHT ON PATTERNS OF CARE AND PROGNOSTIC FACTORS IN ADULT HIGH GRADE GLIOMA: EXPERIENCE FROM A TERTIARY CANCER HOSPITAL FROM EASTERN INDIA
Authors: SEN ANNESHA , MANNA AMITABHA , MANDAL BIDYUT , BASU ABHISHEK
Published: November 2022

Objective: The Central Nervous System Tumors account for 2.4% of all malignancies in India, but are associated with high mortality in high-grade tumors which result in poor death-adjusted life years. This study focuses on patterns of care and prognostic factors of adult high-grade glioma to explore the unaddressed nuances in treating such patients.
Methods: It was a retrospective single institutional study from June 2018 to July 2021 with an age group between 16 to 70 years. All histopathologically or clinicoradiologically proven cases of high-grade (World Health Organization Grades III and IV) gliomas were assessed. Defaulters and recurrent glioma at presentation were excluded from the analysis. Baseline characteristics were analyzed by Chi-square and unpaired t-test, and the Kaplan– Meir test was used for survival analysis. p<0.05 was considered significant.
Results: 41 patients were accrued for final analysis with a median follow-up period of 18 months. The most common histology was Astrocytoma, followed by Glioblastoma with a female preponderance. The Frontal and Temporal lobe was the predominant site in the study population. A majority (82%) of the patients underwent maximal safe resection followed by chemoradiation therapy (63.4%). Median progression free survival was 24 months and 8 months for Grades III and IV gliomas, respectively. The median overall survival for Grade IV gliomas was 7 months.
Conclusion: Resection status, Grade IV, IDH and 1p19q codeletion status were significant prognostic factors, while intensity modulated radiotherapy showed better dosimetry. More prospective randomized studies with larger sample sizes and longer follow-ups are required for validation and drafting an outcome nomogram.
A NUTRITIONAL STUDY OF TRIBAL AND NON-TRIBAL CHILDREN IN THE UDAIPUR REGION
Authors: TRIPATHI NISHA , JAIN SUMAN , SOGANI SONAL , BHATNAGAR SANDEEP , BHATNAGAR MANI
Published: November 2022

Objective: There is an evidence that nutrition has a significant impact on children’s development, adult health, and senescence. It is also known to have an impact on one’s physical and mental faculties. Malnutrition is now understood to be the root cause of a significant variety of health issues. To compare the nutritional condition of 300 (tribal and nontribal) children living in the Udaipur region, a dietary survey was conducted.
Methods: In the present study, 300 tribal and non-tribal children between the ages of 1 and 12 were chosen for a dietary survey to evaluate their nutritional status. The survey was conducted using a questionnaire.
Results and Conclusion: The statistics between tribal and non-tribal children showed that calorie, protein, fat, and carbohydrate intake was lower in the tribal children. When we compared the data between tribal and non-tribal children, we found that the non-tribal children’s calorie, protein, fat, and carbohydrate intake was not superior. Ascorbic acid and B-carotene intake among non-tribals is also less than that advised by the ICMR and is approximately twice as low as that among their tribal counterparts. The statistics on tribal and non-tribal children made it abundantly evident that nutritional intake is low that consumption of fat among dense nutrients is significantly lower and that intake of antioxidant nutrients such as ascorbic acid and beta-carotene is similarly poor.
Facets and Artifices of War: A Historical Reading of “The Warrior’s Soul” by Joseph Conrad
Authors: Thiam Oumar
Published: November 2022

This paper closely observes the code of conduct of the war actors engaged in a Napoleonic war. In “The Warrior’s Soul”, the latter, as a palimpsest, is reminiscent of no other crisis than the Grand Army’s invasion of Tsar Alexander’s Russia in 1812. Narrowing down its attack and occupation field in this short-story under our study, this history-based conflict unfolds to show a manifest Franco-Russian opposition if we consider Moscow and Paris metropolis as a space-time. In the second and final phase of the short-story, what we find as the Moscow narration, the story on the war bends exclusively over the military herds which are depicted from a battlefield equally chaotic and horrific. In such apocalyptic disorder, the patriotic and conservative will of the Russian adjutant and Officer is put in competition with a heroic altruism we relate to the Tomassov-De Castel case. By looking deeper and deeper into the story of experience marked with the Russian pride and patriotism and that of the Franco-Russian duo, our analysis of “The Warrior’s Soul” as a polemic and historic writing further exposes the horrors and illusions of a war to better exalt honour, ethics and dignity within humans.
Design and Implementation of Medicine Reminder Box and Health Checker
Authors: Karan Gardare , Vaishnavi Gawali , Suhani Gore , Hritik Dhawale , S.B Prof. Hiranawle
Published: November 2022

Abstract: Good health has been a major concern since the inception of mankind whilst for some people attaining good health requires taking prescribed medicines or pills routinely. It’s Very Important for Patients As General And Specially Patients Who Must Have Their Medication Permanently (Diabetics And Hypertension Ect.) Sometimes They Need To Be Reminded, This Frequent Observation Shows That People Give More Interest To Their Work And Other Stuff Than Taking Care Of Their Health . It Is Important To Design And Implement Low Cost Useful Programmable Reminding System. To Help Those Patients .This System Has An Ability To Remind People About Dose Time , Dose Amount Of Medication And Sending SMS To Nursing Staff For More Accuracy And Reliability. The main concept of this project is to create a low cost affordable health monitoring system for people in remote locations where availability of specialist doctors is not possible. This system is portable. Low cost and can be easily operated by anyone with limited knowledge. Also this concept is developed using IoT, so that we can send the data to a remote server from which it can be accessed by doctors
Emerging Trends in Data Security for better Environment
Authors: Shah Ms. Sapna , Sharma Dr. Shailja
Published: November 2022

Abstract: With the advent of the digital revolution, concerns, organisations, and even governments are turning to computerised systems to demeanour their daily operations. As a result, data security has become a top precedence to protect data from various internet threats and any unauthorised access. As data breach, ransomware, and hack news becomes the norm, it follows that data security trends will also move in tandem with ongoing technological advancement. Due to the rapid reversion of technology, it is essential to find appropriate developing computer technologies. This paper's objective is to identify the most imperative technologies in India by emphasising emergent trends in data security and future trends in computing
Karl Popper y el árbol del conocimiento: la metáfora epistémica como estrategia para la intervención filosófica sobre las ciencias
Authors: Oliva Andrés
Published: November 2022

En este trabajo expondremos críticamente la relación de la epistemología de Karl Popper con la teoría de la evolución darwiniana. Sostenemos que el vínculo que Popper establece entre su teoría del conocimiento y la teoría de la evolución puede analizarse provechosamente mediante la noción de metáfora epistémica (Palma 2019). Sugerimos además que el análisis de la metáfora popperiana permite descubrir una relación concreta entre la filosofía y el trabajo científico: aun cuando la filosofía se conciba como una disciplina encargada de realizar una ‘crítica externa’ objetiva o neutral de las ciencias, la intervención filosófica deriva por lo general en una operación interesada y guiada por ciertos prejuicios filosóficos. Esta operación, lejos de ser un mero ejercicio retórico, produce efectos, como el refuerzo de corrientes científicas que se encuentran en pugna (en este caso, la teoría de la evolución de Lamarck). La posición de Popper, lejos de ser neutral, se define en relación a su propia filosofía e intereses y tiene efectos sobre el campo científico que interviene – en este caso, la biología evolutiva.
El lugar del arte en la opción por una desobediencia epistémica decolonial
Authors: Bolaños Martin
Published: November 2022

La visualización de los modos de hacer de lo sensible en una sociedad globalizada es una forma más de disciplinamiento de la sensibilidad y de sus poéticas. La frontera entre una sensibilidad colonizada y una sensibilidad insurgente se vuelve difusa toda vez que el reparto internacional de lo sensible asigna modos específicos capaces de domesticar las sensibilidades que lo desbordan: aquellas sensibilidades que no pueden ser capturadas ni como mercancía, ni como archivo, ni como patrimonio. El desborde y el exceso de estas sensibilidades que no han sido apresadas en las redes de un mercado internacional del arte ponen en jaque, por su sola existencia, las categorías que la estética, en tanto disciplina moderno-colonial, ha producido para conceptualizar y codificar las sensibilidades (aistesis) neutralizado sus capacidades de testimonio de experiencias de vida históricamente subyugadas.  En este sentido, las estésicas decoloniales desandan el camino trazado, y uno de los modos de este desandar es desarticular o al menos resignificar palabras tales como “arte”, “artista”, “obra”, “producción”, “estética”, o “poética”, entre otras.