bluuebunny/crossref_metadata_2025 huggingface dataset:
Analytical Method Development and Validation for Estimation of Spironolactone and Hydrochlorothiazide in Bulk and Tablet Dosage form by High Performance Liquid Chromatography
Authors: Radhika K. , Pravalika Bitla , Sri. S Ramya
Published: October 2023

Analytical Method Development and Validation for Spironolactone and Hydrochlorothiazide in bulk and Combined Dosage Form by RP-HPLC. New method was established for simultaneous estimation of Spironolactone and Hydrochlorothiazideby RP-HPLC method. The chromatographic conditions were successfully developed for the separation of Spironolactone and Hydrochlorothiazideby using Inertsil C18 (4.6mm ×250mm, 5µm particle size), flow rate was 1.0ml/min, mobile phase ratio was (55:45% v/v) Methanol: Phosphate buffer pH 4.8 (pH was adjusted with ortho phosphoricacid), detection wavelength was 282nm. The instrument used was WATERS Alliance 2695 separation module, Software: Empower 2, 996 PDA detector. The retention times were found to be 1.688mins and 3.282mins. The %purity of Spironolactone and Hydrochlorothiazidewas found to be 99.86%. The system suitability parameters for Spironolactone and Hydrochlorothiazidesuch as theoretical plates and tailing factor were found to be 7586, 1.69 and 6235 and 1.58, the resolution were found to be 10.85. The analytical method was validated according to ICH guidelines (ICH, Q2 (R1)). The linearity study ofSpironolactone and Hydrochlorothiazidewas found in concentration range of 100µg-500µg and 30µg - 70µg and correlation coefficient (r2) was found to be 0.999 and 0.999, % recovery was found to be 100.112% and 100.16%, %RSD for repeatability was 0.1702 and 0.043 respectively. The precision study was precise, robust, and repeatable. The LOD value was found to be 2.1µg/ml and 1.28µg/ml, and LOQ value was 6.3µg/ml and 3.84µg/ml for Spironolactone and Hydrochlorothiaziderespectively. Hence the suggested RP-HPLC method can be used for routine analysis of Spironolactone and Hydrochlorothiazide in API and Pharmaceutical dosage form.
A Review on Inflammation and its Pharmacotherapy
Authors: G. Shinde Monika , D. Sayyad Kaufiya , V. Swami Ganesh , B. Savant Priti , R. Yalmar Pooja , T. Mane Swati
Published: October 2023

Inflammation underlies a wide variety of physiological and pathological processes. The classic instigators of inflammation infection and tissue injury are at one end of a large range of adverse conditions that induce inflammation, and they trigger the recruitment of leukocytes and plasma proteins to the affected tissue site. Tissue stress or malfunction similarly induces an adaptive response, which is referred to here as Para-inflammation. This response relies mainly on tissue resident macrophages and is intermediate between the basal homeostatic state and a classic inflammatory response. Para-inflammation is probably responsible for the chronic inflammatory conditions that are associated with modern human diseases.
Prevalence of C-shaped canal morphology of first and second mandibular molars using Cone-Beam Computed Tomography
Authors: Sara Tabarsa  , Arash Izadi  , Ali Sarbazdalir  , Newsha Eslami
Published: October 2023

Introduction: Due to the importance of familiarity with root canal morphology in order to completely clear the canal and achieve treatment success, the aim of this study was to use Cone-Beam Computed Tomography (CBCT) images to evaluate the frequency and anatomy of C-shaped canals in the first and second mandibular molars. Materials and Methods: In this cross-sectional study, CBCT images of 209 patients (435 teeth) were evaluated to determine the presence of C-shaped canals and their anatomical morphologies along the root, based on Fan classification. Bilateral or unilateral occurrence of C-shaped canals and their relationship with gender, age and tooth location were examined and statistically analyzed using the chi-square test and SPSS 17 software. The significance level was P < 0.05. Results: CBCT images from 209 patients, 103 patients (49.3%) were female and 106 (50.7%) were male. Out of 435 teeth (157 mandibular first molars and 278 mandibular second molars) evaluated, 33 specimens (7.5%) including the 2 first molars (1.27%) and 31 second molars (11.15%) had a C-shaped canal system which were from 25 patients (2 first molars in 2 patients and 31 second molars in 23 patients). The prevalence of bilateral C-shaped canals was among the 97 patients with bilateral second molars (6.18%). There was also no significant relationship between teeth position, gender and the prevalence of C-shaped canals. Conclusion: The configuration of C-shaped canals extensively changes along the length of the root and should be considered during preparation and obturation of root canal system.
Student guides: supporting learning from laboratory experiments through across-course collaboration
Authors: Daae Kjersti , Darelius Elin , Årvik Anne Digranes , Glessmer Mirjam S.
Published: October 2023

We have observed that students often struggle with laboratory experiments. There is a high threshold to getting involved hands-on for fear of ruining an experiment, losing time, or breaking the equipment. More importantly, students have difficulty connecting the theory they learn in lectures and exercises with observations they make in the laboratory. As a result, it is challenging to formulate hypotheses, figure out what observations are needed, and make and interpret observations. We address this challenge by creating across-course collaboration between a basic- and an advanced-level Ocean and Atmosphere Dynamics course, which run during the same study periods and are typically taken in subsequent years. We train students from the advanced-level course to act as "guides" and to support groups of basic-level students doing laboratory experiments with the practicalities of running the experiments, making observations, and facilitating discussions about interpretations by asking open-ended questions. This benefits students from both levels: Basic-level students appreciate the help with new lab equipment and the supporting questions that help them make sense of observations. Advanced-level students understand the importance of questions in the learning process and realize how far they have come in understanding the topic in just one year. They report they would like to act as a guide again. We reflect on which design criteria help make this across-course collaboration successful and where we still see room for improvement. Based on our experience and evaluation, we present recommendations for other teachers that might want to try a similar approach.
Perceptual and automated estimates of infringement in 40 music copyright cases
Authors: Yuan Yuchen , Cronin Charles , Müllensiefen Daniel , Fujii Shinya , Savage Patrick E.
Published: October 2023

Music copyright infringement lawsuits implicate millions of dollars in damages and costs of litigation. There are, however, few objective measures by which to evaluate these claims. Recent music information retrieval research has proposed objective algorithms to automatically detect musical similarity, which might reduce subjectivity in music copyright infringement decisions, but there remains minimal relevant perceptual data despite its crucial role in copyright law. We collected perceptual data from 51 participants for 40 adjudicated copyright cases from 1915–2018 in 7 legal jurisdictions (USA, UK, Australia, New Zealand, Japan, People’s Republic of China, and Taiwan). Each case was represented by three different versions: either full audio, melody only (MIDI), or lyrics only (text). Due to the historical emphasis in legal opinions on melody as the key criterion for deciding infringement, we originally predicted that listening to melody-only versions would result in perceptual judgments that more closely matched actual past legal decisions. However, as in our preliminary study of 17 court decisions (Yuan et al., 2020), our results did not match these predictions. Participants listening to full audio outperformed not only the melody-only condition, but also automated algorithms designed to calculate musical similarity (with maximal accuracy of 83% vs. 75%, respectively). Meanwhile, lyrics-only conditions performed at chance levels. Analysis of outlier cases suggests that music, lyrics, and contextual factors can interact in complex ways difficult to capture using quantitative metrics. We propose directions for further investigation including using larger and more diverse samples of cases, enhanced methods, and adapting our perceptual experiment method to avoid relying on ground truth data only from court decisions (which may be subject to errors and selection bias). Our results contribute data and methods to inform practical debates relevant to music copyright law throughout the world, such as the question of whether, and the extent to which, judges and jurors should be allowed to hear published sound recordings of the disputed works in determining musical similarity. Our results ultimately suggest that while automated algorithms are unlikely to replace human judgments, they may help to supplement them.
PELATIHAN PEMBUATAN MATERI PEMBELAJARAN DENGAN APLIKASI CANVA DI SMPN 1 MAJENE
Authors: Mayapada Retno , Rahayu Putri Indi , Hidayatullah Muhammad
Published: October 2023

Perkembangan teknologi dan informasi menuntut dunia pendidikan selalu menyesuaikan diri untuk meningkatkan mutu pendidikan. Peningkatan kinerja pendidikan akan membutuhkan sistem informasi dan teknologi informasi di masa depan, yang tidak hanya berfungsi sebagai alat pendukung, tetapi dapat menjadi alat yang sangat penting untuk mendukung keberhasilan dunia pendidikan sehingga dapat bersaing di dunia global. Pengembangan kompetensi merupakan hal yang seharusnya dilakukan oleh semua profesional, termasuk guru. Salah satu tantangan bagi guru dan pengembang teknologi pendidikan adalah membuat pembelajaran inovatif yang menyenangkan dan tidak membosankan bagi siswa. Kompetensi guru dalam membuat materi yang menarik dan kreatif berpengaruh terhadap keberhasilan guru dalam membantu siswa mencapai hasil belajar yang lebih baik. Salah satu pemanfaatan teknologi dalam pembelajaran adalah dengan menggunakan aplikasi Canva. Pelatihan menggunakan aplikasi Canva di laksanakan di SMPN 1 Majene. Peserta yang mengikuti kegiatan ini adalah 31 orang guru. Tujuan dari rangkaian kegiatan yang dilaksanakan ialah untuk memberikan pelatihan kepada guru untuk menggunakan aplikasi Canva. Pelatihan ini juga dilakukan berdasarkan observasi, wawancara, dan survei yang dilakukan dengan pihak sekolah. Luaran dari rangkaian kegiatan yang dilakukan adalah guru memperoleh wawasan baru atau penyegaran kembali tentang aplikasi Canva sehingga dapat menggunakan aplikasi Canva untuk membuat materi pembelajaran yang menarik dan kreatif.
Gestión por procesos para la mejora continua de las empresas del sector metalmecánico
Authors: Esponda Véliz Jorge José
Published: October 2023

La presente investigación descriptiva-explicativa, aplicada, no experimental, se realizó con el objetivo de determinar de qué manera la gestión por procesos empresariales puede suministrar elementos necesarios para alcanzar la mejora continua en las empresas del sector metalmecánico de Lima Metropolitana, Para este efecto, se ha utilizado técnicas e instrumentos propios del método descriptivo, tales como guías de análisis documental, encuestas y/o cuestionarios, aplicados a una muestra de 136 personas que laboran en las empresas del sector metalmecánico de Lima Metropolitana. Los datos recogidos sobre las variables X, Y e indicadores se procesaron, analizaron e interpretaron, en función de las hipótesis de trabajo planteadas. El procesamiento de los datos se realizó mediante el sistema SPSS y el análisis estadístico correspondió al uso del método de mínimos cuadrados. La prueba estadística utilizada para el contraste de las hipótesis fue la Prueba de Ji cuadrado, con la cual se demuestra la aceptación de la hipótesis alterna, que indica que el modelo de gestión por procesos empresariales (Variable X: independiente) es favorable para la mejora continua de la gestión empresarial (Variable Y: dependiente) del sector metalmecánico, de Lima Metropolitana, ya que suministra de manera significativa (al 95% de confianza) los elementos esenciales necesarios, tales como el proceso sistemático de gestión, los estándares, el control y la economía, haciendo que la empresas persigan productividad y efectividad, calidad y competitividad.
FRACTURES CAUSES AND TYPES DESCRIPTION IN DRAJAT PRAWIRANEGARA HOSPITAL SERANG INDONESIA
Authors: Rachmat Omat , Fiddiyanti Ilma
Published: October 2023

Fractures are often associated with considerable morbidity, leading to extended hospital stays. Disturbances due to fractures impact activity tolerance, thereby reducing productivity. Fracture is a term for loss of continuity of bone or cartilage, either total or partial. In general, a fracture is caused by trauma or physical exertion. This case report consists of four types of fractures in the Drajat Prawiranegara Hospital Serang Indonesia: transverse fractures, cumulative fractures, oblique, segmental, impacted, and spiral fractures. Causes of fractures can be divided into traumatic injuries, direct, indirect, sudden violent contractions, pathological fractures, bone tumours, chronic infections, rickets, and term bone stress. The gold standard examination used to determine the location, type, and severity is an x-ray radiology examination.
Application of Multivariate Modelling to Global Warming Projections
Authors: Liu Zhaorui , Cui Meiling , Sun Shuai , Wang Qiang , Yang Wenjing , Li Ruizhen , Yue Xiucheng
Published: October 2023

Global warming is a natural phenomenon in which the accumulation of energy in the Earth's atmospheric system leads to an increase in temperature. To build the model, we collected multiple datasets from the 20th century: average annual global temperatures, average monthly temperatures at different latitudes, global losses from various natural disasters, global emissions of various chemicals, and population. We then pre-processed and visualized the data. In our quantitative analysis, we found that the increase in global temperature in March 2022 did not exceed the increase in the past 10 years. We then developed three models to describe past and project future global temperature levels: the GM(1,1) model, the ARIMA(0,1,1) model, and the Holt model. By primarily comparing the fit of the three models, we concluded that the Holt model has the highest prediction accuracy. We found that the relationship between time and global temperature.
Optimization of Navigation Route Planning Based on Image Capture Technology
Authors: Wan Ziqi
Published: October 2023

In recent years, navigation systems have become an integral part of our daily lives, helping us find the most efficient route to our destination. However, traditional navigation systems rely heavily on existing road maps and satellite data, which may not always provide accurate real-time information. To address this limitation, image capture technology has emerged as a promising solution to collect real-time visual data for optimized navigation route planning. This article aims to explore various aspects of image capture technology and its potential to enhance navigation systems. We discuss the challenges of navigation route planning using image capture techniques and propose several optimization techniques to overcome these challenges. The research presented in this paper highlights the benefits of incorporating image capture technology into navigation systems, including improved accuracy, real-time updates, and enhanced user experience. Through an extensive review of existing literature, case studies, and practical implementations, we provide valuable insights into optimizing navigation route planning using image capture techniques.
Research and Design of High-precision Voltage Sampling Circuit for Tumor Radiofrequency Ablation Medical Instrument
Authors: Yao Xin
Published: October 2023

Radiofrequency ablation is a minimally invasive procedure in which tiny radiofrequency electrodes are implanted into the diseased tissue under the guidance of medical imaging (X-ray imager, CT or ultrasound), and neutral electrodes are attached to the skin of the body to carry out radiofrequency ablation, which is carried out by forming a circuit through the human body to the diseased tissue. At present, RF ablation can be applied to lung tumors, liver tumors, kidney tumors and certain heart diseases. The core component of tumor RF ablation surgery equipment is RF power source, which is a fixed frequency sinusoidal AC output signal with a frequency of 400-500Khz. The detection technology of RF voltage is extremely important, which determines the accuracy of RF ablation energy output and energy control. In this paper, we use STM32 microcontroller as the core of acquisition and control, and propose a simple and practical sampling method with high accuracy. Moreover, we have realized to control the voltage measurement error below 1% by using the error curve fitting method for software calibration.
Design of a Five-story Brick-concrete Structure Building Demolition Scheme by Folding Blasting
Authors: Sheng Shang
Published: October 2023

There are several schemes for controlled blasting demolition of buildings, including in-situ collapse, inward collapse, directional collapse, unidirectional collapse, and bidirectional collapse. The choice of blasting plan is mainly influenced by the structure and geometric size of the explosive, the surrounding environment, and the initiating equipment. This article designs a folding blasting demolition plan for a 5-story brick concrete structure building. Based on the structural dimensions of the building to be demolished and the surrounding environmental map. Only the south side of the building is relatively open and can provide a site for the collapse of the building, so the directional dumping blasting plan towards the south is chosen. Adopting a comprehensive protective system to eliminate or minimize blasting hazards as much as possible. This blasting adopts a hybrid blasting network with electric detonators detonating non electric detonators. Each blasting hole has one detonator, which is connected with one segment of detonator inside the hole and one segment of detonator outside the hole. After every 20 detonators are clustered together, they are connected to a double detonator to form a connection point, and then the connection points are double connected to form a blasting network.
The Quality Teaching and Learning Satisfaction on Physical Education Courses Among Students in A Government University in Guangdong, China
Authors: Li Yuexing
Published: October 2023

Through literature survey, questionnaire survey and other methods, this paper studies and analyzes the influence of PE teaching quality on students' learning satisfaction and the existing problems, hoping to understand the current situation of students' satisfaction with PE courses in Guangdong University of Science and Technology, find out the existing problems, and analyze the main factors affecting PE curriculum satisfaction in Guangdong University of Science and Technology. It provides a basis for Guangdong University Science and Technology to optimize the learning and teaching level of PE courses, and provides a certain experience and theoretical basis for promoting the deepening reform of physical education courses in Chinese universities.
Demonstrating Portfolio Frontier Formation and the Capital Allocation Line Using Interactive Graphing
Authors: LaBorde Pamela , Rystrom David
Published: October 2023

This paper shows how to use interactive graphing via scroll bars to create a two-security portfolio frontier and the Capital Allocation Line. The frontier is enhanced via the use of spinners to control the correlation coefficient and the weight of risky assets as well as data labels that track the weight of the stocks along the frontier as a scroll bar is incremented. The VLOOKUP function is incorporated to lookup the calculated expected return and standard deviation of the risky portfolio at a stock weight controlled by a spinner. The purpose of this paper is to aid instructors in explaining the concepts of investment opportunity sets or frontiers, including the efficient and inefficient portions and riskless lending and borrowing to students of investing.
Ftalan dibutylu Metoda oznaczania w powietrzu na stanowiskach pracy
Authors:   Małgorzata Szewczyńska, Dobrzyńska Elżbieta
Published: October 2023

Dibutyl phthalate (DBP) is a reproductive toxicant category 1B. The purpose of the conducted research work was to develop a method for the determination of dibutyl phthalate, which will enable its determination at concentrations of 0.6 mg/m3 . The method involves trapping the aerosol of dibutyl phthalate contained in the air onto a sampler – a glass tube with XAD-2 sorbent and a glass fiber filter, its extraction with an acetone/dichloromethane mixture and chromatographic analysis of the resulting solution. The study was performed with the use of gas chromatography with a mass spectrometry (RTX-5silMS Column). Validation of the method was carried out in accordance with the requirements of the European standard PN-EN 482. The method allows for the determination of a compound in the air of the working environment in a concentration range of 0.06 mg/m3 to 1.2 mg/m3 . The method for the determination of dibutyl phthalate is presented in form of an analytical procedure, which is included in the appendix. This article discusses the problems of occupational safety and health, which are covered by health sciences and environmental engineering.
Geoprocessamento e análise espacial relacionadas a coinfecção tuberculose/vírus da imunodeficiência humana: revisão integrativa
Authors: Scholze Alessandro Rolim , Eduarda Lucio de Oliveira Maria , Cristina Melo Emiliana , Renata Fagundes Tatiane , Fordellone Rosa Cruz Carolina , Cremer Edivaldo
Published: October 2023

Objetivo: investigar as evidências científicas referente às técnicas de geoprocessamento e análise espacial relacionadas à coinfecção tuberculose/Vírus da Imunodeficiência Humana. Método: revisão integrativa da literatura de artigos publicados, sem recortes temporais e de idioma, com diferentes desenhos de estudos, disponíveis eletronicamente nas bases de dados Literatura Latino-Americana e do Caribe em Ciências da Saúde, Base de Dados de Enfermagem, Web of Science, Excerpta Medica DataBASE e National Library of Medicine National Institutes of Health. Utilizou-se como pergunta de pesquisa: quais as evidências científicas referentes às técnicas de geoprocessamento e análise espacial relacionadas à coinfecção tuberculose/Vírus da Imunodeficiência Humana? O software State of the Art through Systematic Review foi utilizado para o gerenciamento do banco de dados, e os dados foram apresentados em forma descritiva. Resultados: a pesquisa resultou em 1.837 artigos. Desses, dez artigos compuseram a amostra. As principais técnicas utilizadas foram Moran, varredura espacial e modelagem espacial. Quanto às principais características relacionadas à coinfecção tuberculose/Vírus da Imunodeficiência Humana, destacam-se baixo nível de riqueza, acesso precário à saúde, raça preta/parda e indígena, baixa escolaridade, mulheres, idade avançada com risco de mortalidade. Conclusão: entende-se que as técnicas de geoprocessamento e análise espacial são de extrema importância para a identificação de áreas de risco espacial, além de auxiliarem no desenvolvimento de ações de saúde em territórios específicos, fator esse que contribui positivamente com a gestão e a saúde pública.
Health Considerations for Female Orthopaedic Surgeons
Authors: Chou Loretta B. , Kha Stephanie T. , Shapiro Lauren M.
Published: October 2023

The number of female orthopaedic surgeons is increasing. They face unique health concerns, which include cancer risk, pregnancy and fertility problems, musculoskeletal issues, and mental health disorders. In 2010, a survey study showed a 2.9-fold increased prevalence of breast cancer in female orthopaedic surgeons, compared with women in the general US population. A follow-up study 13 years later showed a 3.97-fold higher prevalence of breast cancer in female orthopaedic surgeons compared with matched women in the US general population. Surveys on fertility have also reported that orthopaedic surgery is one of three surgical subspecialty fields with the highest rates of fertility difficulty. In addition, the rate of pregnancy loss in female surgeons was twice the rate compared with that of the general population. There is an increased risk of preterm delivery in female orthopaedic surgeons. Awareness, education, and preventive measures may help reduce these issues and thereby promote the recruitment, retainment, and success of female surgeons in orthopaedic surgery.
Bilateral Posterior Fracture-Dislocation of the Shoulders Secondary to Uremic Encephalopathy
Authors: Mencia Marlon M. , Goalan Raakesh
Published: October 2023

Bilateral posterior fracture-dislocation of the shoulder is an uncommon injury pattern usually caused by epileptic seizures. The cause of the seizure activity remains unknown in most cases, although the injury has been associated with several conditions. A 59-year-old man with uncontrolled hypertension presented with new-onset generalized tonic-clonic seizures. He was diagnosed with uremic encephalopathy and bilateral posterior fracture-dislocation of his shoulders. His medical condition required stabilization leading to a delay in definitive surgery and a subsequent poor outcome. This case highlights the previously unknown association between bilateral fracture-dislocation of the shoulders and seizures caused by uremic encephalopathy. In these complex situations with competing clinical priorities, it is important to initiate prompt treatment of the cause in any new-onset seizures, to facilitate expedient surgical management of the orthopaedic injury.
Efektivitas Pembuatan Lubang Tanam di Perkebunan Kelapa Sawit dengan Quality Control Circle
Authors: Yudhi Pramudya  , Yeremia Pandiangan  , Galuh Banowati  , Sukarji
Published: October 2023

The study investigates the effectiveness of planting hole creation in oil palm plantations using the Quality Control Circle (QCC). Field observations were conducted to measure the hole-digging tool's diameter and depth before and after modification. Results showed that the modified tool is more effective than the old tool, requiring only 13 seconds per polybag to create holes. The T-PLANT tool produced uniform holes with optimal depth, resulting in improved productivity, reduced costs, and improved work quality. Implementing QCC with this modified tool can enhance the effectiveness of planting hole creation, improve productivity, reduce costs, and improve work quality in oil palm plantations.
ANALISIS PENERAPAN PRINSIP 5C+1A DALAM PROSES PEMBERIAN PEMBIAYAAN MIKRO PADA BANK SYARIAH
Authors: Chasanah Uswatun , Firmansyah Muhibuddin
Published: October 2023

Sharia Bank, inchanneling funds through financing, it is necessary to apply the principle of prudence todebtor, among which can be applied is p5C principles which include:Character, Capacity, Capital, Collateral, dan Condition of Economic. In addition, it is also necessary to consider aspects of 1A (Sharia) in decision making. The purpose of this study is to find out about the application of the 5C + 1A principles in the process of providing microfinance to Islamic banks.This study uses a qualitative method with a descriptive approach. By using two data sources, namely primary data obtained by conducting interviews with Islamic banks, secondary data obtained from literature, books, journals, the internet and previous research. In data analysis, the authors here use an inductive way of thinking that starts with data and information about the application of the 5C+1A principles in the process of providing microfinance to Islamic banks. The results of this study indicate that the application of the 5C+1A principles (Character, Capacity, Capital, Collateral, Condition of Economic and Sharia Aspects) in the process of providing microfinance to Islamic banks is carried out to prevent the process of providing financing that is not on target in order to minimize bad financing. However, even though the 5C + 1A principles have been implemented, bad/problem financing is sometimes unavoidable, so Islamic banks also need to implement a strategy for solving them.
Unveiling the immunomodulatory mechanisms of pineapple metabolites: A multi-modal computational analysis using network pharmacology, molecular docking, and molecular dynamics simulation
Authors: Tallei Trina , Fatimawali Fatimawali , Yelnetty Afriza , Niode Nurdjannah , Kusumawaty Diah , Idroes Rinaldi , Celik Ismail , Emran Talha
Published: October 2023

The exploration of the immunomodulatory potential of pineapple metabolites holds promise for substantial implications across several fields, encompassing medicine, pharmacology, nutrition, and public health. This study explores potential immune-regulating properties of secondary pineapple metabolites beyond bromelain, using computational techniques. Pineapple juice's secondary metabolites were identified via LC-MS-based metabolomics, selected using KNApSAcK Kanaya and Dr. Duke's databases. A heatmap was generated with Orange v.3.27.0. Bioactivity predictions utilized the PASS Online webserver, while ADMET properties were forecasted. Network pharmacology explored metabolite interactions with protein targets. Molecular docking focused on compounds against receptors, choosing robust interactors for dynamic simulations. Our findings revealed that certain metabolites from pineapple juice/fermented juice exhibited interactions with proteins associated with pro-inflammatory cytokines. Specifically, the molecular docking results indicated that the carbohydrate moiety of bromelain (CMB) interacted strongly with TLR2, while 9,10-Dihydroxystearic acid showed strong interactions with NLRP3 (inflammasome). The flexibility and stability of these complexes were further assessed through molecular dynamics simulations conducted over a 50-ns time period. The MM-PBSA calculations also indicated low binding free energies between these complexes, suggesting strong molecular interactions. These findings suggest that CMB may interact with TLR2 and 9,10-Dihydroxystearic acid may interact with NLRP3, highlighting their potential as immunomodulatory agents. However, further experimental studies are warranted to confirm the therapeutic efficacy of these molecules and investigate their mechanisms of action in vivo.
Bacteriological profile and antibiotic susceptibility of bacteria isolated from diabetic foot ulcers at the National Hospital of Niamey
Authors: Ousmane Abdoulaye , Souley Sanda , Ahamadou Biraima , Aziz Moumouni , Laouali Harouna , Fatima Guiet , dou Maman , Boukar Sidi , Boubou Laouli , ois Tapsoba
Published: October 2023

Objective:
The objective of our work was to determine the bacteriological profile and antibiotic sensitivity of bacteria isolated from diabetic foot wounds.
Methods:
We conducted a descriptive cross-sectional study from July 1 to December 31, 2020. During this period, all diabetic patients with wounds were sampled. The different samples were plated on appropriate media. The identification of the isolated bacterial strains as well as the study of their sensitivity to antibiotics was performed according to conventional methods.
Results:
A total of 689 diabetic patients were followed during this period, 58 (8.41%) had infected foot wounds. The average age was 53.6 years with a sex ratio (M/F) of 1.15. Bacteriological analyses allowed the isolation of 48 bacterial strains (10 different species) with a predominance of Staphylococcus aureus (35.42%), followed by Klebsiella pneumoniae (20.84%), Escherichia coli (12.50%), Enterobacter aerogenes (10.42%). We observed a predominance of Gram-negative bacilli (56.25%). The sensitivity tests performed on the identified bacteria showed that 100% of the enterobacteria strains were sensitive to Ertapenem and Imipenem, except for Proteus mirabilis. Four strains were tested for extended-spectrum betalactamase (ESBL) and none were producers. All Gram positive cocci isolates were sensitive to vancomycin and resistant to penicillin G. Staphylococcus aureus strains were sensitive to erythromycin (82.35%), Kanamycin (82.35%) and Oxacillin (82.35%).
Conclusion:
These results show that diabetic foot wound infections are becoming more frequent. It is necessary to manage them with adequate antibiotic therapy based on an antibiogram to avoid the spread of multi-resistant bacterial strains.
Relapse and complications of brucellosis: Findings of a disease quality registry
Authors: Keramat Fariba , Karami Manochehr , Mamani Mojgan , Saadatmand Ali , Hashemi Seyyed , Alikhani Mohammad , Bashirian Saeid , Shivapour Zahra
Published: October 2023

Background:
Brucellosis can be chronic or associated with relapse and complications like other chronic diseases, and quality registry system is required.
Aim:
This study was designed and carried out with the aim of recording the quality of relapse and complications of brucellosis in Hamadan, west of Iran.
Methods:
In a quality registry study, in the first phase, all patients referred to Sina Hospital and Imam Khomeini Clinic in Hamadan were entered the study from September 2015 to January 2017. All information of the patients including demographic characteristics, clinical signs and symptoms, complications and laboratory findings have been entered in the questionnaire and designed software of quality regiatry of relapse and complications of brucellosis.
Results:
A total of 248 patients with brucellosis with a mean age of 43.38± 17.67 (range: 13 to 92) years old were enrolled the study, of which 155 patients (62.5%) were male and 80.65% of patients lived in rural areas.The most common complications were sacroilitis 33.06% ( 95% CI: 27.24%, 39.29%), arthritis 29.44% (95% CI: 23.83%, 35.53%) (the most common involvement were left and right knee joints 38.36% and 35. 62%, respectively), spondylitis 22.98% (95% CI: 17.89%, 28.72%) (in lumbar vertebrae L4 and L5 were 70.18% and 68.24%, respectively), epididymorchitis (14.84%, 95% CI: 9.64%, 21.42%) in men, neurobrucellosis (3.63%, 95% CI: 1.67%, 6.77%), hepatitis (1.21%, 95% CI: 0.25%, 3.53%), and abortion in 3 of 4 pregnant women and one case of eye involvement.
Conclusion:
The results of this study can be used for evidence-based decision-making to diagnose and better management of relapse and complications in patients with brucellosis.
A cross-sectional study of learning style preference among 2nd-year medical graduates using modified VARK questionnaire based on new curriculum
Authors: Sundararajan Prasannakumari , Anthonisamy Prasanna , Paulraj Vinupradha , Azeez Abdhul
Published: October 2023

Background: Medical education is a continuous learning process which requires the students and instructors to update themselves. Learning style refers to consistent and enduring tendencies or preference for learning. It is important to assess the learning styles of students to cater for their differing learning needs. Research has demonstrated that learners have four basic perceptual learning modalities, that are Visual (V), Auditory (A), Tactile (R), and Kinesthetic (K).

Aims and Objectives: The aim of this study is to analyze the learning preference among 2nd-year Medical graduates using modified validated VARK questionnaire based on new curriculum. The completed questionnaires were collected and statistically evaluated.

Materials and Methods: A descriptive cross-sectional study was conducted on 101 medical graduates. Validated VARK questionnaire was used to categorize the learning preference. Students were instructed to tick or circle the most preferred learning style.

Results: Most of them preferred multimodal (64.35%) learning style as compared to unimodal (35.6%). In multimodal, majority of the students preferred bimodal (47.5%) learning style. In unimodal, majority of the students preferred aural (14.8%) followed by visual (11.8%) mode of learning style.

Conclusion: The new curriculum has modified and increased learning activities among the students. Understanding student’s learning styles can make teaching-learning more effective. Assessment of students’ learning style is a valuable skill in education. Knowledge of learning styles may help educators to identify and solve learning problems among students, thus helping the students to become more effective learners.
Serum electrolyte disturbance and significance in late stages of chronic kidney disease
Authors: P Kalyani , V Balasubramaniyan , A Saravanan , K Thamaraiselvi , K Prabhavathi , S Kanimozhi , L Bhavya , Bhavsar Nikhil
Published: October 2023

Background: Electrolyte and acid–base balance are crucially regulated by the kidneys. Derangements in electrolytes unavoidably arise with progressive kidney function loss and negatively impact patient outcomes. Medical professionals are increasingly faced with these issues as chronic kidney disease (CKD) has spread like an epidemic around the world. Diabetes and hypertension remain the important etiology of CKD and also facilitate the complications of the CKD like electrolyte impairment and the resulting condition has worsened the comorbid disease as a positive feedback manner.

Aims and Objectives: This study aims to assess the serum electrolyte variations and significance in pre-dialysis patients and dialysis patients of CKD.

Materials and Methods: The cross-sectional study, which was conducted in the nephrology department of SRM Medical College and Hospital, involved 120 participants between the ages of 30 and 85. It included 60 CKD patients in the pre-dialysis stage and 60 CKD patients in the dialysis stage.

Results: To compare the taste threshold levels for the pre-dialysis and dialysis stages, an independent sample t-test was used. In the dialysis group compared to the pre-dialysis phases of CKD, there was a greater significance noted in the serum phosphate and serum calcium level (P < 0.001). Other electrolytes such as sodium, bicarbonate, chloride, and potassium do not have a significant difference with late stages of CKD.

Conclusion: The disturbance in electrolyte varies by patient’s medical management, food pattern, comorbid disease, and lifestyle. As for serum electrolyte evaluation, most of the patients have normal serum level of potassium, chloride, sodium, and calcium. Moreover, there is a highly serum changes in phosphate and bicarbonate. The significance of electrolyte variation is noted in pre-dialysis and dialysis found on serum phosphate and serum calcium. Meticulously monitoring and predicting electrolyte disturbance can delay the progression and decrease the complication of a CKD.
Pemberdayaan Kemandirian Anak Yatim Panti Asuhan Muhammadiyah Pasar Ambacang Kuranji Padang
Authors: Adek Adha
Published: October 2023

Latar belakang penelitian ini adalah Setiap anak dilahirkan dalam kondisi yang tidak berdaya, ia akan bergantung kepada orang tua dan orang-orang yang berada di sekitar lingkungannya sampai waktu tertentu. Seiring dengan berjalannya waktu dan perkembangan hidup, seorang anak akan perlahan-lahan melepaskan diri dari ketergantungannya dengan orang tua atau orang lain disekitarnya belajar untuk menjadi mandiri. Pemberdayaan anak yatim merupakan bagian dari proses sosialisasi yang sangat penting dan paling mendasar karena peran utama pemberdayaan untuk anak yatim adalah mendidik dan mengajarkan anak yatim menjadi masyarakat yang mandiri. Tujuan dari penelitian ini adalah: pertama, Untuk Mengetahui proses penyadaran dalam memberdayakan kemandirian anak yatim di Panti Asuhan Muhammadiyah Pasar Ambacang Kuranji Kota Padang, dan kedua, Untuk Mengetahui proses pengkapasitasan dalam memberdayakan kemandirian anak yatim di Panti Asuhan Muhammadiyah Pasar Ambacang Kuranji Kota Padang. Penelitian ini menggunakan metode penelitian kualitatif yang bersifat  deskriptif atau analisis dengan teknik pengumpulan data Observasi keadaan yang berlangsung, dokumentasi, dan wawancara dengan Pengurus, Pengasuh, masyarakat, dan Anak-anak Yatim. Hasil penelitian ini menunjukkan bahwa; (1) Proses pemberdayaan kemandirian anak yatim melalui tahap penyadaran dilakukan dengan berusaha untuk memberikan pembinaan, bimbingan keagamaan, akhlak,  dan pengembangan potensi yang dapat dimanfaatkan oleh anak yatim dimulai dari program unggulan aktivitas baik formal (pembinaan pengembangan pendidikan mulai tingkat SD hingga tingkat SMA), maupun non formal (dengan kegiatan olahraga dan keagamaan) Sedangkan (2) Proses pemberdayaan kemandirian anak yatim melalui tahap pengkapasitasan ada dua cara yaitu memberikan pendidikan agama Islam seperti pembacaan tilawatil Qur’an, pelatihan didikan subuh, wirid mingguan dan keterampilan kepada anak yatim sebagai usaha untuk menciptakan pribadi yang mandiri seperti keterampilan bakat computer.
Strategi Komunikasi Vaksinasi Covid-19 di Kota Santri Samalanga Tahun 2021
Authors: Ali Marzuki
Published: October 2023

Tujuan dari penelitian ini adalah untuk mendiskripsikan pemerintah Indonesia untuk melawan Covid 19 dengan mengadakan vaksinasi bagi seluruh masyarakat Indonesia. Pandemi Covid-19 yang belum berakhir menuntun pada pelaksanaan Vaksinasi Covid-19 bagi seluruh lapisan masyarakat termaksud Kecamatan Samalanga. Penelitian ini termasuk penelitian deskriptif kualitatif. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah : Observasi, Wawancara, Dekumentasi. Subjek  dari penelitian ini adalah di Kota Santri Samalanga. Hasil penelitian menunjukkan bahwa awalnya msyarakat menolak akan vaksinasi tetapi seiring dengan berjalan waktu masyarakat mulai menerima akan pelaksanaan vaksinasi dengan ada dorongan-dorongan para ulama dan para santri-santri sangat antusiasi dalam pelaksanaan vaksinasi. COVID-19 ini sudah berlansung dari tahun 2019 sampai sekarang. Dan sekarang sudah diberlakukan oleh pemerintah bagi masyarakat diwajibkan untuk vaksinasi, karna sekarang keperluan apapun harus adanya surat keterangan vaksin, dengaan adanya peraturan demikian itu merupakan faktor yang sangat mempengaruhi masyarakat untuk melaksanakan vaksinasi.
Object detection and ship classification using YOLO and Amazon Rekognition
Authors:   Hal Marcus College of Science and Engineering, University of West Florida, Pensacola, FL, United States, Bagui Sikha , Perez Alejandro ,   Hal Marcus College of Science and Engineering, University of West Florida, Pensacola, FL, United States
Published: October 2023

The need for reliable automated object detection and classification in the maritime sphere has increased significantly over the last decade. The increased use of unmanned marine vehicles necessitates the development and use of an autonomous object detection and classification systems that utilize onboard cameras and operate reliably, efficiently, and accurately without the need for human intervention. As the autonomous vehicle realm moves further away from active human supervision, the requirements for a detection and classification suite call for a higher level of accuracy in the classification models. This paper presents a comparative study using different classification models on a large maritime vessel image dataset. For this study, additional images were annotated using Roboflow, focusing on the types of subclasses that had the lowest detection performance, a previous work by Brown et al. (1). The present study uses a dataset of over 5,000 images. Using the enhanced set of image annotations, models were created in the cloud using Google Colab using YOLOv5, YOLOv7, and YOLOv8 as well as in AmazonWeb Services using Amazon Rekognition. The models were tuned and run for five runs of 150 epochs each to collect efficiency and performance metrics. Comparison of these metrics from the YOLO models yielded interesting improvements in classification accuracies for the subclasses that previously had lower scores, but at the expense of the overall model accuracy. Furthermore, training time efficiency was improved drastically using the newer YOLO APIs. In contrast, using Amazon Rekognition yielded superior accuracy results across the board, but at the expense of the lowest training efficiency.
INTERVENÇÕES PSICOTERAPÊUTICAS SENSÍVEIS A DIVERSIDADE SEXUAL E DE GÊNERO: REFLEXÕES PARA A PRÁTICA CLÍNICA E A DOCÊNCIA DO ENSINO SUPERIOR
Authors: Campos Floyd Siqueira
Published: October 2023

O tema proposto neste trabalho de revisão bibliográfica busca analisar e refletir sobre as intervenções psicoterapêuticas sensíveis a diversidade sexual e de gênero, com o intuito de contribuir para a prática clínica e a docência no ensino superior, promovendo a inclusão e o bem-estar psicológico de indivíduos pertencentes a comunidade LGBTQIAPN+. Ao aprofundar-se nessas questões, a pesquisa busca desconstruir preconceitos e estigmas presentes na prática clínica e na docência, visando promover uma abordagem terapêutica mais inclusiva e alinhada com os princípios de respeito à diversidade e aos direitos humanos. Para que o trabalho atingisse seu objetivo foi necessário a utilização de livros, artigos, monografias, dissertações entre outros, configurando uma pesquisa bibliográfica. Os resultados obtidos podem fornecer subsídios para o desenvolvimento de práticas mais conscientes e comprometidas com a saúde mental e o bem-estar dos pacientes LGBTQIAPN+ e, ao mesmo tempo, oferecer sugestões para aprimorar a formação profissional no campo da psicologia.
POTENCIALIDADES E DESAFIOS NO USO DE SISTEMAS DE INFORMAÇÃO EM SAÚDE NA ATENÇÃO BÁSICA DE PORTO ALEGRE
Authors: Pedroso Regina , Flores Cecília Dias
Published: October 2023

O uso de tecnologias tem avançado cada vez mais a fim de oferecer organização e qualificação aos serviços públicos de saúde. Neste sentido, o presente estudo teve por objetivo compreender a percepção dos profissionais da Atenção Primária em Saúde quanto ao uso cotidiano do e- SUS. Quanto aos aspectos metodológicos, trata-se de uma pesquisa exploratória e descritiva, com abordagem quantitativa e qualitativa, realizada na cidade de Porto Alegre, Rio Grande do Sul. Responderam ao questionário quantitativo 43 profissionais e o qualitativo 17, todos vinculados a Coordenadoria Regional Norte de Saúde do município e que utilizam do e-SUS diariamente. Os resultados obtidos a partir dos relatos dos participantes foram categorizados em: Importância do e-SUS, Uso cotidiano do sistema, Treinamento e Gestão e comunicação. Conclui-se que sua utilização é importante para a melhoria do atendimento e continuidade do cuidado, contribuindo para otimização dos processos de trabalho. Entretanto, ainda existem aspectos e concepções que dificultam a incorporação ideal dessa tecnologia, como falta de treinamento adequado, apoio técnico e comunicação entre os demais sistemas da rede.
INKONSISTENSI REGULASI PEMILIHAN UMUM DI INDONESIA DALAM MENANGGAPI PROBLEMATIKA SOSIAL
Authors: Mubaraq Zulham , Fatimah Siti
Published: October 2023

Penelitian ini bertujuan untuk menjelaskan pentingnya regulasi yang membahas tentang pemilihan umum yang terjadi saat ini, bagaimana polemic serta pelanggaran dan kejahatan yang terjadi dalam proses pemilihan umum. Sehingga terciptanya Undang-Undang Nomor 17 tahun 2017 yang membahas tentang mekanisme pemilihan umum yang sesuai dengan kontitusional dan demokratis. Di bahas juga terkait regulasi pengawas pemilihan umum yang dalam hal ini sebagai pengawas dan juga sebagai pemutus pelanggaran dan sengketa proses pemilu. Selain itu juga penelitian ini membahas tindak penegakan hokum serta tindak pidana pemilu yang dimaksud agar pemilih dalam hal ini masyarakat mengetahui bagaimana proses pemidanaan dalam kasus pemilu. Tak hanya itu saja denga adanya gagasan pembentukan peradilan khusus untuk memutuskan sengketa pemilu di daerah juga sangat di perlukan demi terselenggaranya hak demokrasi yang jujur serta menciptakan suasana yang kondusif.